Cancer_type QTL_type tag_SNP LD SNP SNP_position Alleles Methylation_probe Methylation_position Probe_related_gene Beta t-stat Correlation_coefficient (r) p-value Traits CESC cis rs10208940 0.920 rs6724540 chr2:68779356 A/G cg12452813 chr2:68675892 NA 0.52 5.16 0.3 4.88e-7 Urate levels in lean individuals; CESC cis rs11122272 0.735 rs910823 chr1:231498766 G/T cg06096015 chr1:231504339 EGLN1 0.43 6.26 0.36 1.57e-9 Hemoglobin concentration; CESC cis rs2562152 0.706 rs216598 chr16:108585 T/C cg02949481 chr16:131562 MPG 0.54 6.1 0.35 3.77e-9 Glioblastoma; CESC cis rs1609391 0.543 rs7651085 chr3:136625339 C/G cg15507776 chr3:136538369 TMEM22 0.82 11.97 0.59 1.08e-26 Neuroticism; CESC cis rs9611565 0.559 rs132761 chr22:42004371 C/T cg06634786 chr22:41940651 POLR3H 0.62 6.26 0.36 1.58e-9 Vitiligo; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00306532 chr1:2323029 MORN1;RER1 -0.44 -6.99 -0.39 2.28e-11 Gambling; CESC trans rs3942852 0.868 rs10769315 chr11:48110367 A/G cg15704280 chr7:45808275 SEPT13 -0.63 -7.52 -0.42 8.6e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs9325144 0.647 rs870431 chr12:38953073 T/C cg26384229 chr12:38710491 ALG10B -0.55 -7.83 -0.43 1.16e-13 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16003274 chr5:139944379 APBB3;SLC35A4 -0.46 -6.32 -0.36 1.11e-9 Fibrinogen levels; CESC cis rs7818345 0.534 rs34221121 chr8:19319625 G/A cg11303988 chr8:19266685 CSGALNACT1 0.34 5.37 0.31 1.71e-7 Language performance in older adults (adjusted for episodic memory); CESC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg18876405 chr7:65276391 NA 0.5 6.64 0.38 1.75e-10 Aortic root size; CESC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg25036284 chr2:26402008 FAM59B 0.88 9.99 0.52 3.79e-20 Gut microbiome composition (summer); CESC cis rs12530845 0.830 rs73721678 chr7:135355710 T/G cg23117316 chr7:135346802 PL-5283 -0.44 -5.2 -0.3 3.94e-7 Red blood cell traits; CESC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg27121462 chr16:89883253 FANCA 0.74 10.59 0.55 4.54e-22 Vitiligo; CESC cis rs35110281 0.840 rs2838331 chr21:45026728 A/G cg01579765 chr21:45077557 HSF2BP 0.53 8.99 0.48 4.79e-17 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24327389 chr8:11882982 NA -0.69 -8.5 -0.46 1.38e-15 Gut microbiome composition (summer); CESC cis rs854765 0.693 rs8079321 chr17:17760789 C/T cg04398451 chr17:18023971 MYO15A -0.65 -9.69 -0.51 3.35e-19 Total body bone mineral density; CESC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg06873352 chr17:61820015 STRADA 0.73 12.81 0.62 1.49e-29 Prudent dietary pattern; CESC cis rs897984 0.806 rs8052245 chr16:30916430 C/G cg00531865 chr16:30841666 NA 0.56 7.97 0.44 4.63e-14 Dementia with Lewy bodies; CESC cis rs1355223 0.583 rs2941057 chr11:34882220 G/A cg24088639 chr11:34937564 PDHX;APIP -0.4 -5.12 -0.3 5.76e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs3762637 0.941 rs9837149 chr3:122230845 G/C cg24169773 chr3:122142474 KPNA1 -0.61 -7.18 -0.4 7.12e-12 LDL cholesterol levels; CESC cis rs72901758 0.768 rs11659046 chr17:76245718 G/A cg23302638 chr17:76210176 BIRC5 0.5 5.56 0.32 6.7e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs7551222 0.789 rs4951408 chr1:204558984 C/G cg20240347 chr1:204465584 NA -0.28 -5.88 -0.34 1.24e-8 Schizophrenia; CESC cis rs3857536 0.785 rs2157964 chr6:66938419 A/G cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg11764359 chr7:65958608 NA -0.66 -8.51 -0.46 1.32e-15 Aortic root size; CESC cis rs1580019 0.587 rs7805311 chr7:32558302 A/G cg07520158 chr7:32535189 LSM5;AVL9 -0.5 -6.26 -0.36 1.56e-9 Cognitive ability; CESC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg26939375 chr7:64535504 NA 0.77 11.14 0.56 6.67e-24 Aortic root size; CESC cis rs4919687 0.550 rs12783444 chr10:104480659 G/A cg04362960 chr10:104952993 NT5C2 0.49 5.63 0.33 4.64e-8 Colorectal cancer; CESC cis rs854765 0.583 rs8065416 chr17:17851162 C/T cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg10523679 chr1:76189770 ACADM 0.67 6.54 0.37 3.13e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7769051 1.000 rs7769051 chr6:133146796 G/T cg22852734 chr6:133119734 C6orf192 0.91 9.84 0.52 1.14e-19 Type 2 diabetes nephropathy; CESC cis rs17253792 0.822 rs17832371 chr14:56162302 C/A cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs11638352 1.000 rs2615288 chr15:44415886 T/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs9527 0.501 rs12244388 chr10:104640052 G/A cg15744005 chr10:104629667 AS3MT -0.38 -5.91 -0.34 1.06e-8 Arsenic metabolism; CESC cis rs6063312 1.000 rs6063313 chr20:47343532 G/A cg18078177 chr20:47281410 PREX1 0.56 5.49 0.32 9.32e-8 Tonometry; CESC trans rs61931739 0.500 rs7308338 chr12:34553181 A/G cg26384229 chr12:38710491 ALG10B 0.56 7.85 0.43 1.02e-13 Morning vs. evening chronotype; CESC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg18876405 chr7:65276391 NA -0.52 -7.18 -0.4 6.89e-12 Aortic root size; CESC cis rs7089973 0.872 rs3180654 chr10:116615045 T/C cg23260525 chr10:116636907 FAM160B1 0.38 6.37 0.36 8.29e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs397969 0.596 rs35315252 chr17:19905825 A/G cg12073167 chr17:19770448 ULK2 -0.46 -5.28 -0.31 2.63e-7 Platelet count; CESC trans rs3942852 0.774 rs10838813 chr11:48186969 C/A cg15704280 chr7:45808275 SEPT13 -0.73 -8.25 -0.45 7.61e-15 Acute lymphoblastic leukemia (childhood); CESC cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg07697082 chr8:82753677 SNX16 -0.41 -5.63 -0.33 4.47e-8 Diastolic blood pressure; CESC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.12 0.49 1.92e-17 Menopause (age at onset); CESC trans rs7672847 0.547 rs61516087 chr4:170367800 A/G cg19308436 chr1:237949471 RYR2 0.6 6.27 0.36 1.46e-9 Subjective well-being; CESC cis rs6540559 0.546 rs74991018 chr1:210033790 T/G cg21951975 chr1:209979733 IRF6 0.58 6.23 0.36 1.85e-9 Cleft lip with or without cleft palate; CESC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.68 0.38 1.37e-10 Bipolar disorder; CESC cis rs2816062 0.813 rs2745314 chr1:18902851 T/A cg18795169 chr1:18902165 NA -0.93 -18.04 -0.74 5.1e-48 Urate levels in lean individuals; CESC cis rs208520 0.690 rs207114 chr6:66791703 C/T cg07460842 chr6:66804631 NA -1.01 -13.21 -0.63 6.06e-31 Exhaled nitric oxide output; CESC cis rs2762353 0.526 rs9461203 chr6:25710555 C/T cg25753631 chr6:25732923 NA 0.26 5.14 0.3 5.41e-7 Blood metabolite levels; CESC cis rs614226 0.935 rs2235222 chr12:120892193 G/C cg01236616 chr12:121019343 POP5 -1.45 -16.8 -0.72 1.26e-43 Type 1 diabetes nephropathy; CESC cis rs854765 0.693 rs9907287 chr17:17774118 C/T cg04398451 chr17:18023971 MYO15A 0.68 10.1 0.53 1.73e-20 Total body bone mineral density; CESC cis rs662064 0.852 rs616402 chr1:10566272 C/T cg20482658 chr1:10539492 PEX14 0.37 7.4 0.41 1.79e-12 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20925763 chr2:219879821 CCDC108 -0.55 -6.61 -0.38 2.15e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05602567 chr22:32871203 FBXO7 -0.58 -6.61 -0.38 2.12e-10 Gut microbiome composition (summer); CESC cis rs2439831 0.681 rs498837 chr15:43608024 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.82 12.34 0.6 5.9e-28 Lung cancer in ever smokers; CESC cis rs7165102 0.930 rs7167657 chr15:65964479 C/T cg11441148 chr15:65824328 PTPLAD1 0.3 5.06 0.3 7.69e-7 Mean corpuscular hemoglobin; CESC cis rs1018836 0.923 rs13268594 chr8:91588545 G/T cg16814680 chr8:91681699 NA -0.69 -9.71 -0.51 2.89e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg00463507 chr1:36235431 CLSPN 0.51 6.45 0.37 5.2e-10 Attention deficit hyperactivity disorder; CESC cis rs17125944 0.505 rs77690283 chr14:53233320 C/G cg13660082 chr14:53194042 PSMC6 -0.65 -5.88 -0.34 1.23e-8 Alzheimer's disease (late onset); CESC cis rs3820068 0.608 rs10927840 chr1:16045250 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.72 0.33 2.88e-8 Systolic blood pressure; CESC trans rs7246760 1.000 rs67844335 chr19:9898039 G/A cg02900749 chr2:68251473 NA -0.83 -7.08 -0.4 1.3e-11 Pursuit maintenance gain; CESC cis rs2985684 0.748 rs2985686 chr14:50100683 C/G cg02151108 chr14:50098012 C14orf104 -0.44 -5.52 -0.32 7.91e-8 Carotid intima media thickness; CESC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg07414643 chr4:187882934 NA 0.54 7.9 0.44 7.51e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs14978 0.628 rs4721058 chr7:12267256 C/T cg23422036 chr7:12250390 TMEM106B 0.38 5.17 0.3 4.7e-7 Response to amphetamines; CESC cis rs10504229 0.906 rs2270609 chr8:58194684 G/A cg22535103 chr8:58192502 C8orf71 -1.07 -13.39 -0.64 1.44e-31 Developmental language disorder (linguistic errors); CESC trans rs11098499 0.644 rs6855918 chr4:120546299 C/T cg25214090 chr10:38739885 LOC399744 0.63 8.89 0.48 9.62e-17 Corneal astigmatism; CESC cis rs3806843 0.966 rs3756338 chr5:140180561 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.25 -0.31 3.13e-7 Depressive symptoms (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20959894 chr7:27779871 TAX1BP1 0.57 6.44 0.37 5.52e-10 Gut microbiome composition (summer); CESC cis rs2262909 0.962 rs409439 chr19:22227432 C/T cg11619707 chr19:22235551 ZNF257 -0.32 -5.26 -0.31 2.94e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs11785400 0.793 rs12546978 chr8:143750205 T/A cg24634471 chr8:143751801 JRK -0.46 -5.64 -0.33 4.35e-8 Schizophrenia; CESC cis rs7762018 0.941 rs4716384 chr6:170109184 T/A cg13891659 chr6:170190454 C6orf122;C6orf208 0.55 5.63 0.33 4.55e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg27286337 chr10:134555280 INPP5A 0.68 7.72 0.43 2.33e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs5758659 0.652 rs5751195 chr22:42380001 A/C cg04733989 chr22:42467013 NAGA 0.47 6.23 0.36 1.8e-9 Cognitive function; CESC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg25036284 chr2:26402008 FAM59B -0.73 -8.34 -0.46 3.98e-15 Gut microbiome composition (summer); CESC cis rs137699 1.000 rs2049986 chr22:39756854 C/G cg05872129 chr22:39784769 NA 0.41 5.43 0.32 1.29e-7 IgG glycosylation; CESC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg03934478 chr11:495069 RNH1 0.56 5.39 0.31 1.54e-7 Body mass index; CESC cis rs6831352 0.959 rs6532795 chr4:100042221 C/T cg12011299 chr4:100065546 ADH4 -0.72 -8.84 -0.48 1.4e-16 Alcohol dependence; CESC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.7 -7.95 -0.44 5.54e-14 Gut microbiome composition (summer); CESC cis rs7914558 0.966 rs56946876 chr10:104653545 T/C cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.45e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs8028182 0.636 rs7166737 chr15:75682513 A/G cg20655648 chr15:75932815 IMP3 0.46 5.82 0.34 1.69e-8 Sudden cardiac arrest; CESC cis rs7726839 0.561 rs72703044 chr5:579737 G/A cg09021430 chr5:549028 NA -0.44 -5.96 -0.34 8.23e-9 Obesity-related traits; CESC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.61 -0.33 5.14e-8 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13265914 chr8:21999630 REEP4 0.55 7.24 0.41 4.95e-12 Gut microbiota (bacterial taxa); CESC trans rs35146811 0.695 rs858509 chr7:99821470 A/G cg13215871 chr17:75784724 NA -0.34 -6.33 -0.36 1.07e-9 Coronary artery disease; CESC cis rs6964587 0.967 rs7801058 chr7:91784381 C/T cg17063962 chr7:91808500 NA 0.51 6.93 0.39 3.25e-11 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01027365 chr2:191184571 HIBCH 0.44 6.13 0.35 3.21e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs2903152 chr4:99067992 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.96 0.34 7.81e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg18904891 chr8:8559673 CLDN23 0.42 5.06 0.3 7.89e-7 Mood instability; CESC cis rs881375 0.678 rs1930782 chr9:123687905 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.48 0.32 9.71e-8 Rheumatoid arthritis; CESC cis rs56309584 0.673 rs7219471 chr17:8121594 G/T cg06726167 chr17:8076949 TMEM107 -0.5 -5.1 -0.3 6.44e-7 Initial pursuit acceleration; CESC cis rs2836974 0.931 rs2776309 chr21:40715791 A/G cg11890956 chr21:40555474 PSMG1 1.05 15.72 0.69 8.58e-40 Cognitive function; CESC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg06873352 chr17:61820015 STRADA 0.73 12.94 0.62 5.33e-30 Prudent dietary pattern; CESC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg18904891 chr8:8559673 CLDN23 0.73 8.15 0.45 1.43e-14 Obesity-related traits; CESC cis rs2191566 0.761 rs446016 chr19:44501518 A/G cg20607764 chr19:44506953 ZNF230 -0.53 -6.53 -0.37 3.38e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs10861342 1.000 rs11112359 chr12:105471661 C/A cg23923672 chr12:105501055 KIAA1033 0.69 5.09 0.3 6.84e-7 IgG glycosylation; CESC cis rs2625529 0.938 rs4776579 chr15:72132608 C/T cg16672083 chr15:72433130 SENP8 -0.43 -6.11 -0.35 3.54e-9 Red blood cell count; CESC cis rs9837602 0.938 rs9823908 chr3:99795507 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.48 6.74 0.38 9.99e-11 Breast cancer; CESC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg00409905 chr10:38381863 ZNF37A 0.5 6.82 0.39 6e-11 Extrinsic epigenetic age acceleration; CESC cis rs8072100 0.748 rs9912592 chr17:45556945 G/A cg08085267 chr17:45401833 C17orf57 -0.58 -7.67 -0.43 3.39e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs67460515 0.500 rs6806015 chr3:160724766 G/A cg03342759 chr3:160939853 NMD3 -0.43 -5.44 -0.32 1.23e-7 Parkinson's disease; CESC cis rs7084402 0.967 rs1658442 chr10:60318897 G/A cg07615347 chr10:60278583 BICC1 0.63 10.12 0.53 1.48e-20 Refractive error; CESC cis rs11608355 0.515 rs4766476 chr12:109934700 A/G cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs3096299 0.748 rs2965822 chr16:89444677 A/T cg00750074 chr16:89608354 SPG7 -0.37 -5.19 -0.3 4.1e-7 Multiple myeloma (IgH translocation); CESC cis rs8141529 0.732 rs5762784 chr22:29171298 C/T cg15103426 chr22:29168792 CCDC117 0.7 9.95 0.52 5e-20 Lymphocyte counts; CESC cis rs1865721 1.000 rs7236756 chr18:73175689 T/C cg26385618 chr18:73139727 C18orf62 -0.48 -7.17 -0.4 7.58e-12 Intelligence; CESC cis rs7845219 0.544 rs34293080 chr8:95908078 G/T cg23172400 chr8:95962367 TP53INP1 -0.4 -7.52 -0.42 8.27e-13 Type 2 diabetes; CESC cis rs72781680 0.898 rs72782117 chr2:24026921 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.7 0.38 1.22e-10 Lymphocyte counts; CESC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg18512352 chr11:47633146 NA -0.54 -8.02 -0.44 3.49e-14 Subjective well-being; CESC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg18016565 chr1:150552671 MCL1 0.33 5.09 0.3 6.65e-7 Tonsillectomy; CESC cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg22875332 chr1:76189707 ACADM 0.71 9.95 0.52 4.86e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.6 -0.38 2.19e-10 Developmental language disorder (linguistic errors); CESC cis rs11786130 1.000 rs10956401 chr8:129002419 G/A cg01765152 chr8:129005526 PVT1 -0.32 -5.12 -0.3 5.83e-7 Eosinophil counts;Sum eosinophil basophil counts; CESC cis rs7103648 0.838 rs2293576 chr11:47434986 A/G cg20307385 chr11:47447363 PSMC3 -0.89 -14.13 -0.66 3.62e-34 Diastolic blood pressure;Systolic blood pressure; CESC cis rs6088580 0.634 rs2424992 chr20:33012060 C/T cg24642439 chr20:33292090 TP53INP2 0.53 6.95 0.39 2.87e-11 Glomerular filtration rate (creatinine); CESC cis rs10242455 0.702 rs78680379 chr7:99198573 G/A cg18809830 chr7:99032528 PTCD1 -0.89 -5.53 -0.32 7.8e-8 Blood metabolite levels; CESC cis rs4474465 0.541 rs10736814 chr11:78286462 C/G cg27205649 chr11:78285834 NARS2 0.45 5.7 0.33 3.2e-8 Alzheimer's disease (survival time); CESC cis rs26868 0.742 rs26848 chr16:2263516 A/G cg25665528 chr16:2260870 C16orf79 -0.33 -5.42 -0.32 1.36e-7 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13305165 chr3:25831802 NGLY1;OXSM -0.44 -6.26 -0.36 1.55e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg17366294 chr4:99064904 C4orf37 -0.6 -8.67 -0.47 4.29e-16 Colonoscopy-negative controls vs population controls; CESC cis rs17253792 0.822 rs78261053 chr14:56061784 C/T cg01858014 chr14:56050164 KTN1 -0.96 -7.13 -0.4 9.72e-12 Putamen volume; CESC cis rs425277 1.000 rs262665 chr1:2083173 A/G cg24578937 chr1:2090814 PRKCZ 0.55 9.54 0.51 9.57e-19 Height; CESC cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg08847533 chr14:75593920 NEK9 0.92 16.29 0.71 8.22e-42 Height; CESC cis rs10781543 0.839 rs7863766 chr9:139381314 T/G cg14019695 chr9:139328340 INPP5E 0.38 5.67 0.33 3.72e-8 Monocyte percentage of white cells; CESC cis rs524281 0.861 rs3862386 chr11:65894424 G/C cg14036092 chr11:66035641 RAB1B -0.61 -5.95 -0.34 8.3e-9 Electroencephalogram traits; CESC cis rs734999 0.550 rs2985855 chr1:2531372 A/C cg18854424 chr1:2615690 NA -0.27 -5.14 -0.3 5.24e-7 Ulcerative colitis; CESC cis rs72781680 0.898 rs7589440 chr2:24038595 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs9611565 0.559 rs5758397 chr22:42019251 C/T cg03806693 chr22:41940476 POLR3H 1.09 12.86 0.62 9.42e-30 Vitiligo; CESC cis rs7208859 0.673 rs11658344 chr17:29207745 G/T cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg18230493 chr5:56204884 C5orf35 -0.62 -8.35 -0.46 3.92e-15 Initial pursuit acceleration; CESC trans rs9467711 0.790 rs72843784 chr6:26498758 G/T cg06606381 chr12:133084897 FBRSL1 -1.11 -7.59 -0.42 5.41e-13 Autism spectrum disorder or schizophrenia; CESC cis rs7799006 0.606 rs34417375 chr7:2315105 C/T cg12745145 chr7:2261452 MAD1L1 -0.33 -5.19 -0.3 4.25e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.31 -5.12 -0.3 6e-7 Hemoglobin concentration; CESC cis rs9486719 1.000 rs2472895 chr6:96870387 A/T cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs1008375 0.898 rs61047804 chr4:17593965 G/A cg16339924 chr4:17578868 LAP3 0.73 9.5 0.5 1.31e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7927771 0.864 rs2868459 chr11:47454972 C/G cg20307385 chr11:47447363 PSMC3 -0.64 -7.69 -0.43 2.97e-13 Subjective well-being; CESC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg13298116 chr11:62369859 EML3;MTA2 0.64 9.42 0.5 2.35e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs8114671 0.836 rs62213676 chr20:33612676 T/A cg07148914 chr20:33460835 GGT7 -0.41 -5.31 -0.31 2.28e-7 Height; CESC trans rs3749237 1.000 rs4768 chr3:49758764 A/G cg21659725 chr3:3221576 CRBN 0.54 6.45 0.37 5.29e-10 Resting heart rate; CESC cis rs6952809 0.561 rs1548598 chr7:2438912 T/C cg23289794 chr7:2394357 EIF3B -0.7 -6.79 -0.38 7.42e-11 Multiple sclerosis; CESC cis rs754466 0.606 rs56402185 chr10:79585848 G/A cg17075019 chr10:79541650 NA -0.88 -14.17 -0.66 2.7e-34 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs868036 0.957 rs9920662 chr15:68104297 G/A cg08079166 chr15:68083412 MAP2K5 0.43 6.92 0.39 3.35e-11 Restless legs syndrome; CESC cis rs1707322 1.000 rs2458400 chr1:46530798 C/T cg05343316 chr1:45956843 TESK2 -0.44 -5.26 -0.31 2.94e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs652260 1.000 rs590394 chr19:7902505 C/T cg26014689 chr19:7917955 EVI5L -0.44 -5.96 -0.34 8.05e-9 Menarche (age at onset); CESC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg07936489 chr17:37558343 FBXL20 -0.82 -12.08 -0.6 4.62e-27 Glomerular filtration rate (creatinine); CESC cis rs1545257 0.537 rs2702088 chr2:24642535 G/C cg06627628 chr2:24431161 ITSN2 -0.48 -5.88 -0.34 1.21e-8 Sjögren's syndrome; CESC cis rs9303401 0.614 rs34843288 chr17:57103140 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.97 11.03 0.56 1.59e-23 Cognitive test performance; CESC cis rs12477438 0.765 rs1453564 chr2:99564428 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -9.04 -0.49 3.51e-17 Chronic sinus infection; CESC cis rs11098499 0.866 rs11098506 chr4:120284971 A/G cg09307838 chr4:120376055 NA 0.88 11.94 0.59 1.41e-26 Corneal astigmatism; CESC cis rs738322 1.000 rs738322 chr22:38569006 A/G cg25457927 chr22:38595422 NA -0.29 -5.52 -0.32 8.28e-8 Cutaneous nevi; CESC cis rs796364 0.906 rs281789 chr2:200780698 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.87 8.44 0.46 2.14e-15 Schizophrenia; CESC cis rs1707322 0.752 rs11488313 chr1:46224780 G/C cg06784218 chr1:46089804 CCDC17 0.39 6.86 0.39 4.83e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11122272 0.735 rs2486746 chr1:231497324 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -7.45 -0.42 1.34e-12 Hemoglobin concentration; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg00162751 chr1:220921532 MOSC2 -0.44 -6.41 -0.37 6.49e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4664308 0.691 rs1877196 chr2:160915150 G/T cg03641300 chr2:160917029 PLA2R1 -0.63 -9.45 -0.5 1.84e-18 Idiopathic membranous nephropathy; CESC cis rs847577 0.715 rs4729402 chr7:97707731 A/G cg21770322 chr7:97807741 LMTK2 0.43 6.34 0.36 9.81e-10 Breast cancer; CESC cis rs1949733 1.000 rs3103071 chr4:8508579 C/G cg11789530 chr4:8429930 ACOX3 -0.73 -10.07 -0.53 2.01e-20 Response to antineoplastic agents; CESC cis rs7589342 0.929 rs6725519 chr2:106445209 A/G cg16077055 chr2:106428750 NCK2 -0.49 -7.04 -0.4 1.6e-11 Addiction; CESC cis rs1784581 0.928 rs1789995 chr6:162396518 C/T cg17173639 chr6:162384350 PARK2 -0.79 -12.86 -0.62 9.59e-30 Itch intensity from mosquito bite; CESC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg18402987 chr7:1209562 NA 0.76 8.45 0.46 1.91e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8180040 0.966 rs56351005 chr3:47430186 G/T cg27129171 chr3:47204927 SETD2 -0.64 -9.82 -0.52 1.29e-19 Colorectal cancer; CESC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg18765753 chr7:1198926 ZFAND2A -0.36 -5.1 -0.3 6.5e-7 Longevity;Endometriosis; CESC cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg25517755 chr10:38738941 LOC399744 -0.47 -6.04 -0.35 5.12e-9 Extrinsic epigenetic age acceleration; CESC cis rs12451471 0.637 rs12452616 chr17:78090081 A/G cg06718696 chr17:78121285 EIF4A3 -0.86 -10.69 -0.55 2e-22 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg07308232 chr7:1071921 C7orf50 -0.61 -8.56 -0.47 9.45e-16 Longevity;Endometriosis; CESC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg12963246 chr6:28129442 ZNF389 -0.49 -6.56 -0.37 2.83e-10 Depression; CESC cis rs8067354 0.540 rs12600680 chr17:58037374 T/C cg02344993 chr17:57696989 CLTC 0.53 5.39 0.31 1.59e-7 Hemoglobin concentration; CESC cis rs7918232 0.941 rs7096505 chr10:27326999 T/C cg14240646 chr10:27532245 ACBD5 -0.57 -5.43 -0.32 1.26e-7 Breast cancer; CESC cis rs1372520 0.684 rs2737010 chr4:90746466 G/A cg15133208 chr4:90757351 SNCA -0.39 -5.18 -0.3 4.45e-7 Neuroticism; CESC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg25036284 chr2:26402008 FAM59B -0.59 -6.9 -0.39 3.85e-11 Gut microbiome composition (summer); CESC cis rs6701037 0.681 rs13374887 chr1:175131962 A/T cg00321850 chr1:175162397 KIAA0040 0.44 6.4 0.37 7.2e-10 Alcohol dependence; CESC cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg22875332 chr1:76189707 ACADM 0.63 6.94 0.39 3.02e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11167764 0.895 rs9324865 chr5:141488792 T/C cg08523384 chr5:141488047 NDFIP1 -0.37 -5.44 -0.32 1.23e-7 Crohn's disease; CESC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg02931644 chr1:25747376 RHCE -0.39 -6.5 -0.37 4.08e-10 Erythrocyte sedimentation rate; CESC cis rs929354 1.000 rs1182410 chr7:157063837 C/T cg05182265 chr7:156933206 UBE3C 0.44 6.05 0.35 4.86e-9 Body mass index; CESC cis rs2710642 0.693 rs10168771 chr2:62903187 G/A cg17519650 chr2:63277830 OTX1 0.57 6.72 0.38 1.14e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs7662987 0.517 rs1453874 chr4:100022724 G/A cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.21e-14 Smoking initiation; CESC cis rs9398803 0.965 rs6919397 chr6:126659043 A/C cg19875578 chr6:126661172 C6orf173 0.4 5.55 0.32 6.99e-8 Male-pattern baldness; CESC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg18225595 chr11:63971243 STIP1 0.52 5.13 0.3 5.55e-7 Mean platelet volume; CESC cis rs5758659 0.714 rs2284087 chr22:42485671 T/C cg19513890 chr22:42538836 CYP2D7P1 0.37 5.44 0.32 1.19e-7 Cognitive function; CESC cis rs61931739 0.500 rs6488215 chr12:34434803 A/T cg06521331 chr12:34319734 NA -0.37 -5.12 -0.3 5.98e-7 Morning vs. evening chronotype; CESC cis rs7084402 1.000 rs6481402 chr10:60268977 T/C cg07615347 chr10:60278583 BICC1 -0.57 -8.72 -0.47 3.03e-16 Refractive error; CESC cis rs1395 0.710 rs58965570 chr2:27481460 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 5.57 0.32 6.24e-8 Blood metabolite levels; CESC cis rs1008375 0.966 rs12503517 chr4:17698725 G/A cg02297831 chr4:17616191 MED28 0.44 5.33 0.31 2.07e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs281302 0.621 rs373553 chr15:47749001 G/C cg15377044 chr10:47688638 ANTXRL -0.42 -6.01 -0.35 6.01e-9 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CESC trans rs899596 0.955 rs9903496 chr17:71736940 A/G cg23413066 chr4:13548755 LOC285548 -0.38 -6.04 -0.35 5.14e-9 Glucose homeostasis traits; CESC cis rs7827545 1.000 rs4909911 chr8:135565255 G/A cg17885191 chr8:135476712 NA 0.48 6.28 0.36 1.39e-9 Hypertension (SNP x SNP interaction); CESC cis rs589448 0.934 rs554591 chr12:69753847 T/C cg14784868 chr12:69753453 YEATS4 0.92 14.57 0.67 1.05e-35 Cerebrospinal fluid biomarker levels; CESC cis rs6570726 0.935 rs369214 chr6:145856709 G/A cg23711669 chr6:146136114 FBXO30 0.8 11.74 0.58 6.58e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs769267 0.566 rs9304962 chr19:19679992 G/C cg03709012 chr19:19516395 GATAD2A -0.68 -8.39 -0.46 2.84e-15 Tonsillectomy; CESC cis rs3540 0.597 rs1978151 chr15:91037300 C/T cg10434728 chr15:90938212 IQGAP1 0.42 7.36 0.41 2.28e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs60733400 0.667 rs4385650 chr1:2499898 G/A cg20673091 chr1:2541236 MMEL1 0.39 6.32 0.36 1.13e-9 Multiple sclerosis; CESC cis rs11785400 0.793 rs4736367 chr8:143742477 G/A cg10596483 chr8:143751796 JRK 0.42 5.31 0.31 2.32e-7 Schizophrenia; CESC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.02 0.8 8.62e-62 Prudent dietary pattern; CESC cis rs6088580 0.601 rs6059872 chr20:33082775 C/A cg08999081 chr20:33150536 PIGU 0.66 11.6 0.58 2.04e-25 Glomerular filtration rate (creatinine); CESC cis rs3820068 0.608 rs6668919 chr1:16049893 A/G cg17385448 chr1:15911702 AGMAT -0.4 -6.33 -0.36 1.05e-9 Systolic blood pressure; CESC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg09699651 chr6:150184138 LRP11 0.43 5.6 0.33 5.25e-8 Lung cancer; CESC cis rs28647808 0.881 rs28625799 chr9:136264557 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC cis rs2832191 0.791 rs8134407 chr21:30476586 G/A cg24692254 chr21:30365293 RNF160 0.78 12.05 0.59 5.98e-27 Dental caries; CESC cis rs10791097 0.668 rs10791102 chr11:130744977 G/A cg12179176 chr11:130786555 SNX19 0.64 9.87 0.52 8.97e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg23161317 chr6:28129485 ZNF389 0.43 5.64 0.33 4.38e-8 Depression; CESC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg19318889 chr4:1322082 MAEA 0.46 6.19 0.36 2.29e-9 Longevity; CESC cis rs34779708 0.931 rs12261654 chr10:35322024 G/A cg04310649 chr10:35416472 CREM -0.51 -6.24 -0.36 1.76e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26247329 chr5:180670940 GNB2L1;SNORD95 -0.63 -7.0 -0.4 2.15e-11 Gut microbiome composition (summer); CESC cis rs929354 0.772 rs6957939 chr7:156978485 T/C cg05182265 chr7:156933206 UBE3C -0.51 -7.5 -0.42 9.58e-13 Body mass index; CESC cis rs2425143 0.818 rs11167280 chr20:34560526 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.11 -0.4 1.1e-11 Blood protein levels; CESC cis rs2953145 0.545 rs2975751 chr2:241521135 G/A cg07929629 chr2:241523174 NA 0.63 8.28 0.45 6.17e-15 Bipolar disorder; CESC cis rs17376456 0.741 rs7718842 chr5:93480568 G/A cg21475434 chr5:93447410 FAM172A 0.91 7.66 0.43 3.51e-13 Diabetic retinopathy; CESC cis rs17376456 0.825 rs12716453 chr5:93271697 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.65 5.32 0.31 2.26e-7 Diabetic retinopathy; CESC cis rs2408955 0.522 rs6580650 chr12:48418556 G/T cg24011408 chr12:48396354 COL2A1 -0.57 -8.65 -0.47 5.05e-16 Glycated hemoglobin levels; CESC cis rs7084402 0.935 rs1658456 chr10:60304326 C/T cg07615347 chr10:60278583 BICC1 0.58 9.11 0.49 2.1e-17 Refractive error; CESC cis rs7666738 0.830 rs34070283 chr4:98893027 A/T cg17366294 chr4:99064904 C4orf37 0.56 7.75 0.43 1.99e-13 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 1.000 rs4815405 chr20:25317492 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.9 -18.66 -0.75 3.54e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg07395648 chr5:131743802 NA -0.46 -6.16 -0.35 2.68e-9 Breast cancer; CESC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs9487051 0.698 rs11153168 chr6:109629420 A/T cg01475377 chr6:109611718 NA -0.4 -5.62 -0.33 4.91e-8 Reticulocyte fraction of red cells; CESC cis rs2404602 0.647 rs11072616 chr15:76985269 T/C cg23625390 chr15:77176239 SCAPER -0.47 -6.58 -0.37 2.44e-10 Blood metabolite levels; CESC trans rs60843830 1.000 rs7566279 chr2:281178 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 8.23 0.45 8.6e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7824557 0.602 rs7833966 chr8:11206220 C/G cg21775007 chr8:11205619 TDH 0.58 8.81 0.48 1.71e-16 Retinal vascular caliber; CESC cis rs11792861 0.781 rs17729408 chr9:111740860 A/G cg13535736 chr9:111863775 C9orf5 0.46 5.99 0.35 6.71e-9 Menarche (age at onset); CESC cis rs1153858 1.000 rs1618874 chr15:45622786 A/G cg21132104 chr15:45694354 SPATA5L1 0.78 10.44 0.54 1.35e-21 Homoarginine levels; CESC cis rs6963495 0.818 rs73192122 chr7:105171471 G/A cg02135003 chr7:105160482 PUS7 -0.46 -5.5 -0.32 9.1e-8 Bipolar disorder (body mass index interaction); CESC trans rs10242455 0.717 rs2687134 chr7:99331042 T/G cg09045935 chr12:6379348 NA -0.58 -6.08 -0.35 4.15e-9 Blood metabolite levels; CESC cis rs10924309 0.737 rs6701023 chr1:245854503 C/G cg00036263 chr1:245852353 KIF26B 0.53 7.22 0.41 5.56e-12 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg03060546 chr3:49711283 APEH 0.43 5.33 0.31 2.09e-7 Parkinson's disease; CESC cis rs870825 0.616 rs28416641 chr4:185617999 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs146201400 1 rs146201400 chr1:26645955 G/GA cg18121669 chr1:26560928 CCDC21 0.44 5.23 0.31 3.5e-7 Monocyte percentage of white cells; CESC cis rs2637266 1.000 rs7098790 chr10:78361077 T/A cg18941641 chr10:78392320 NA 0.41 7.89 0.44 7.84e-14 Pulmonary function; CESC cis rs7918232 1.000 rs7918232 chr10:27369162 A/G cg14240646 chr10:27532245 ACBD5 -0.55 -5.72 -0.33 2.88e-8 Breast cancer; CESC trans rs6089829 0.925 rs6122086 chr20:61664528 T/C cg23505145 chr19:12996616 KLF1 0.52 6.65 0.38 1.68e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs79057730 0.639 rs6463933 chr7:793954 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.65 5.75 0.33 2.5e-8 Initial pursuit acceleration; CESC cis rs7762018 1.000 rs6941766 chr6:170131653 A/G cg05834625 chr6:170176447 C6orf70 0.66 7.84 0.43 1.07e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs11250464 0.804 rs11250463 chr10:1406228 T/C cg08668359 chr10:1443807 ADARB2 0.56 6.76 0.38 8.99e-11 Radiation response; CESC cis rs6831352 0.918 rs29001202 chr4:100053782 T/A cg12011299 chr4:100065546 ADH4 -0.59 -6.49 -0.37 4.3e-10 Alcohol dependence; CESC cis rs4654899 0.733 rs10799678 chr1:21322785 C/T cg05370193 chr1:21551575 ECE1 0.38 5.88 0.34 1.26e-8 Superior frontal gyrus grey matter volume; CESC cis rs17666538 0.585 rs336437 chr8:636251 A/C cg13264159 chr8:625131 ERICH1 -0.78 -6.28 -0.36 1.37e-9 IgG glycosylation; CESC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.42 0.37 6.1e-10 Bipolar disorder; CESC cis rs17818399 0.926 rs13033177 chr2:46831062 C/A cg02822958 chr2:46747628 ATP6V1E2 0.47 5.71 0.33 3.07e-8 Height; CESC cis rs4555082 0.874 rs78923231 chr14:105754033 C/T cg27165867 chr14:105738592 BRF1 -0.49 -5.15 -0.3 5.14e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7667 1.000 rs10917436 chr1:19708618 T/A cg15026089 chr1:19640712 PQLC2 -0.31 -5.18 -0.3 4.43e-7 Crohn's disease and psoriasis; CESC cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg03467027 chr4:99064603 C4orf37 0.43 5.47 0.32 1.02e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11958404 0.932 rs7711898 chr5:157430688 A/G cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg17971929 chr21:40555470 PSMG1 0.94 12.96 0.62 4.46e-30 Cognitive function; CESC cis rs7605827 0.866 rs11678132 chr2:15533998 C/T cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC trans rs17116334 1.000 rs17116334 chr11:113961762 C/T cg26681847 chr11:120208749 ARHGEF12 0.37 6.22 0.36 1.89e-9 Conduct disorder (maternal expressed emotions interaction); CESC cis rs2034088 0.833 rs9748016 chr17:410451 G/T cg06217071 chr17:408420 NA 0.47 9.11 0.49 2.11e-17 Hip circumference adjusted for BMI; CESC cis rs4595586 0.545 rs9668716 chr12:39378833 G/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg22800045 chr5:56110881 MAP3K1 0.81 10.13 0.53 1.33e-20 Initial pursuit acceleration; CESC cis rs72901758 0.768 rs72901762 chr17:76244926 A/G cg23302638 chr17:76210176 BIRC5 0.47 5.39 0.31 1.59e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC trans rs9929218 1.000 rs12596061 chr16:68807828 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.36 -0.46 3.68e-15 Colorectal cancer; CESC cis rs2295359 1.000 rs11209007 chr1:67619345 C/G cg03340356 chr1:67600835 NA 0.3 5.04 0.3 8.52e-7 Psoriasis; CESC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs6582630 0.599 rs1851114 chr12:38424671 C/T cg26384229 chr12:38710491 ALG10B -0.44 -5.95 -0.34 8.28e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs4148883 0.645 rs2851287 chr4:100014548 G/A cg12011299 chr4:100065546 ADH4 0.68 9.84 0.52 1.15e-19 Alcohol dependence; CESC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg01238044 chr22:24384105 GSTT1 -0.52 -6.54 -0.37 3.15e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04872869 chr1:28908637 SNORA16A;SNHG12 0.49 6.15 0.35 2.87e-9 Gut microbiota (bacterial taxa); CESC cis rs61861422 0.543 rs34309159 chr10:134419166 C/T cg26818010 chr10:134567672 INPP5A -0.57 -5.42 -0.32 1.34e-7 Primary sclerosing cholangitis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10519709 chr1:204347359 NA -0.51 -6.7 -0.38 1.25e-10 Ulcerative colitis; CESC cis rs7845219 0.544 rs2945554 chr8:95939594 C/A cg09323728 chr8:95962352 TP53INP1 -0.33 -6.35 -0.36 9.35e-10 Type 2 diabetes; CESC cis rs116095464 0.558 rs61689490 chr5:224904 T/C cg22857025 chr5:266934 NA -1.27 -18.88 -0.76 5.63e-51 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21041514 chr17:40333411 KCNH4 -0.39 -6.0 -0.35 6.28e-9 Fibrinogen levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23731836 chr8:29120779 KIF13B 0.48 6.64 0.38 1.78e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs111756027 0.593 rs9924848 chr16:77245971 G/A cg01504555 chr16:77246968 SYCE1L 0.61 5.76 0.33 2.34e-8 Bone mineral density (Ward's triangle area); CESC cis rs7264396 0.733 rs2425105 chr20:34312834 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.58 0.42 5.71e-13 Total cholesterol levels; CESC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg05872129 chr22:39784769 NA 0.83 11.61 0.58 1.8e-25 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs523522 0.923 rs1048830 chr12:120882217 G/T cg12219531 chr12:120966889 COQ5 0.72 8.89 0.48 9.44e-17 High light scatter reticulocyte count; CESC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg05132306 chr1:1846340 CALML6 -0.3 -6.37 -0.36 8.33e-10 Body mass index; CESC trans rs9467711 0.606 rs9379900 chr6:26603811 A/C cg06606381 chr12:133084897 FBRSL1 -0.78 -7.41 -0.41 1.7e-12 Autism spectrum disorder or schizophrenia; CESC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg06456125 chr7:65229604 NA 0.44 5.71 0.33 3.09e-8 Calcium levels; CESC cis rs6752107 1.000 rs2241878 chr2:234183718 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.7 0.38 1.27e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg15445000 chr17:37608096 MED1 0.4 6.62 0.38 1.95e-10 Glomerular filtration rate (creatinine); CESC cis rs17376456 0.877 rs10040648 chr5:93490301 G/C cg25358565 chr5:93447407 FAM172A 1.15 11.26 0.57 2.72e-24 Diabetic retinopathy; CESC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg20307385 chr11:47447363 PSMC3 -0.64 -8.23 -0.45 8.82e-15 Subjective well-being; CESC cis rs7582720 1.000 rs72926772 chr2:203804289 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs4808199 0.947 rs10404728 chr19:19595014 C/T cg03709012 chr19:19516395 GATAD2A 1.13 13.2 0.63 6.29e-31 Nonalcoholic fatty liver disease; CESC cis rs131777 0.575 rs131760 chr22:51011936 T/C cg00083937 chr22:51039805 MAPK8IP2 0.38 5.43 0.32 1.27e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs1550582 1.000 rs1550582 chr8:135542084 A/G cg17885191 chr8:135476712 NA -0.61 -7.37 -0.41 2.17e-12 Educational attainment; CESC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.62 -8.04 -0.44 2.94e-14 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02918483 chr4:84406202 FAM175A -0.49 -6.49 -0.37 4.28e-10 Fibrinogen levels; CESC cis rs709400 0.663 rs1028613 chr14:103888324 G/A cg12935359 chr14:103987150 CKB -0.56 -8.21 -0.45 9.64e-15 Body mass index; CESC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg07648498 chr16:89883185 FANCA 0.43 5.3 0.31 2.43e-7 Vitiligo; CESC cis rs12711979 0.509 rs10192699 chr2:3824297 A/G cg17052675 chr2:3827356 NA -0.66 -11.02 -0.56 1.71e-23 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs2985684 1.000 rs7142457 chr14:50097862 C/T cg15316458 chr14:50087796 RPL36AL;MGAT2 0.45 5.15 0.3 4.99e-7 Carotid intima media thickness; CESC cis rs6088580 0.524 rs2889855 chr20:33276853 A/G cg07148914 chr20:33460835 GGT7 -0.4 -5.11 -0.3 6.05e-7 Glomerular filtration rate (creatinine); CESC cis rs11098499 0.865 rs1112817 chr4:120297800 T/C cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg13119609 chr19:45449297 APOC2 -0.53 -8.28 -0.45 6.2e-15 Blood protein levels; CESC cis rs208520 0.690 rs12198745 chr6:66722598 T/C cg07460842 chr6:66804631 NA 0.94 12.59 0.61 8.06e-29 Exhaled nitric oxide output; CESC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg27170947 chr2:26402098 FAM59B -0.6 -7.11 -0.4 1.1e-11 Gut microbiome composition (summer); CESC cis rs1545257 0.505 rs13016195 chr2:24634942 T/C cg06627628 chr2:24431161 ITSN2 -0.47 -5.72 -0.33 2.84e-8 Sjögren's syndrome; CESC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.43 -6.23 -0.36 1.82e-9 IgG glycosylation; CESC cis rs362272 0.505 rs13104157 chr4:3366950 T/C cg08886695 chr4:3369023 RGS12 -0.42 -5.82 -0.34 1.73e-8 Serum sulfate level; CESC cis rs61008539 0.586 rs6959154 chr7:856320 C/T cg00475322 chr7:917719 C7orf20 0.49 7.21 0.41 5.77e-12 Perceived unattractiveness to mosquitoes; CESC cis rs6982240 0.514 rs10481414 chr8:142275326 T/C cg00131261 chr8:142287264 NA -0.54 -7.51 -0.42 8.94e-13 Tonsillectomy; CESC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg07507251 chr3:52567010 NT5DC2 0.32 5.56 0.32 6.75e-8 Bipolar disorder; CESC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs2070488 0.745 rs9838792 chr3:38546726 G/A cg24069376 chr3:38537580 EXOG -0.33 -5.7 -0.33 3.19e-8 Electrocardiographic conduction measures; CESC trans rs264943 0.703 rs264980 chr2:104269979 A/G cg23260255 chr3:187871479 LPP -0.51 -6.15 -0.35 2.91e-9 HIV-1 viral setpoint; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24472218 chr7:112579509 C7orf60 0.6 6.35 0.36 9.29e-10 Gut microbiome composition (summer); CESC cis rs6582630 0.519 rs7294300 chr12:38277359 C/A cg26384229 chr12:38710491 ALG10B 0.72 10.26 0.53 5.3e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs7561273 0.586 rs12477718 chr2:24330539 A/G cg01493198 chr2:24299560 SF3B14 0.41 5.05 0.3 8.11e-7 Quantitative traits; CESC cis rs9486719 1.000 rs2472887 chr6:96865437 A/G cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg19592336 chr6:28129416 ZNF389 0.57 7.34 0.41 2.64e-12 Parkinson's disease; CESC trans rs877282 0.583 rs11253428 chr10:823233 C/T cg22713356 chr15:30763199 NA 1.03 9.37 0.5 3.32e-18 Uric acid levels; CESC trans rs2727020 0.894 rs11040333 chr11:49346332 G/A cg15704280 chr7:45808275 SEPT13 -0.76 -9.32 -0.5 4.9e-18 Coronary artery disease; CESC cis rs6460942 0.915 rs62447639 chr7:12486803 T/C cg20607287 chr7:12443886 VWDE -0.77 -8.71 -0.47 3.35e-16 Coronary artery disease; CESC cis rs35306767 0.953 rs12259801 chr10:959306 C/G cg20503657 chr10:835505 NA 0.75 8.33 0.46 4.53e-15 Eosinophil percentage of granulocytes; CESC cis rs12950390 0.853 rs66471233 chr17:45867086 C/T cg00777063 chr17:45855553 NA -0.38 -5.61 -0.33 5.08e-8 IgG glycosylation; CESC cis rs4728302 0.869 rs6955707 chr7:133612188 G/A cg10665199 chr7:133106180 EXOC4 0.41 5.72 0.33 2.92e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs3862435 0.518 rs2601169 chr15:90913890 T/C cg22089800 chr15:90895588 ZNF774 0.49 5.14 0.3 5.36e-7 Response to exercise (triglyceride level interaction); CESC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg00129232 chr17:37814104 STARD3 -0.6 -7.9 -0.44 7.51e-14 Glomerular filtration rate (creatinine); CESC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg18225595 chr11:63971243 STIP1 0.52 5.17 0.3 4.65e-7 Mean platelet volume; CESC cis rs68170813 0.641 rs74524528 chr7:107090979 G/A cg02696742 chr7:106810147 HBP1 -0.56 -5.19 -0.3 4.1e-7 Coronary artery disease; CESC cis rs7223966 1.000 rs16947005 chr17:61702989 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.44 5.07 0.3 7.41e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs17209837 0.607 rs12539936 chr7:87110017 A/G cg00919237 chr7:87102261 ABCB4 0.48 6.28 0.36 1.38e-9 Gallbladder cancer; CESC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg27170947 chr2:26402098 FAM59B 0.55 6.55 0.37 2.97e-10 Gut microbiome composition (summer); CESC cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg04317338 chr11:64019027 PLCB3 0.93 10.24 0.53 6.06e-21 Mean platelet volume; CESC cis rs9611565 0.643 rs202634 chr22:41809623 A/G cg06481639 chr22:41940642 POLR3H 0.63 6.47 0.37 4.71e-10 Vitiligo; CESC cis rs9400271 0.632 rs4427037 chr6:109585612 G/C cg01475377 chr6:109611718 NA -0.44 -6.9 -0.39 3.76e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs17376456 1.000 rs34068652 chr5:93563319 G/A cg25358565 chr5:93447407 FAM172A 1.17 11.32 0.57 1.64e-24 Diabetic retinopathy; CESC cis rs208520 0.661 rs207090 chr6:66783963 T/A cg07460842 chr6:66804631 NA -1.0 -13.33 -0.63 2.21e-31 Exhaled nitric oxide output; CESC cis rs2243480 1.000 rs1796228 chr7:66033084 G/A cg18252515 chr7:66147081 NA -1.4 -14.23 -0.66 1.55e-34 Diabetic kidney disease; CESC cis rs11098499 0.954 rs7436506 chr4:120393769 T/C cg09307838 chr4:120376055 NA 0.94 13.97 0.65 1.31e-33 Corneal astigmatism; CESC cis rs977987 0.806 rs12599361 chr16:75434973 A/T cg03315344 chr16:75512273 CHST6 0.39 5.52 0.32 8.14e-8 Dupuytren's disease; CESC cis rs763121 0.853 rs5995610 chr22:39064681 C/T cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.58e-7 Menopause (age at onset); CESC cis rs6032067 0.852 rs17424751 chr20:43814622 T/C cg11264863 chr20:43835661 SEMG1 0.49 5.32 0.31 2.21e-7 Blood protein levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12413365 chr12:12510412 LOH12CR1;LOH12CR2 0.46 6.13 0.35 3.15e-9 Systemic lupus erythematosus; CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.51 6.82 0.39 6.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2898290 0.506 rs2736311 chr8:11252170 C/T cg21775007 chr8:11205619 TDH -0.41 -5.94 -0.34 8.91e-9 Systolic blood pressure; CESC cis rs4664293 0.967 rs13020365 chr2:160476404 G/A cg08347373 chr2:160653686 CD302 -0.32 -5.08 -0.3 7.08e-7 Monocyte percentage of white cells; CESC cis rs9322193 0.962 rs2275046 chr6:150157001 A/G cg04369109 chr6:150039330 LATS1 -0.42 -5.62 -0.33 4.9e-8 Lung cancer; CESC cis rs1059312 0.966 rs35907548 chr12:129282180 T/C cg09035930 chr12:129282057 SLC15A4 0.75 10.74 0.55 1.41e-22 Systemic lupus erythematosus; CESC cis rs916888 0.687 rs199456 chr17:44797919 C/T cg15921436 chr17:44337874 NA 0.75 7.9 0.44 7.36e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1178968 0.748 rs10271751 chr7:72752062 T/C cg25889504 chr7:72793014 NA 0.47 5.03 0.3 8.91e-7 Triglyceride levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11540416 chr15:72668720 HEXA;C15orf34 -0.56 -6.07 -0.35 4.37e-9 Gut microbiome composition (summer); CESC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg13880726 chr7:1868755 MAD1L1 0.51 6.75 0.38 9.19e-11 Bipolar disorder and schizophrenia; CESC cis rs13191362 0.808 rs13217502 chr6:163231414 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.6 5.95 0.34 8.39e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.17.48901521F chr17:51546522 NA -0.49 -6.06 -0.35 4.6e-9 Gut microbiome composition (summer); CESC cis rs9858542 0.953 rs10640 chr3:49454277 G/A cg07274523 chr3:49395745 GPX1 0.66 8.13 0.45 1.66e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.12 -0.3 5.89e-7 Life satisfaction; CESC cis rs3809566 1.000 rs3809566 chr15:63333724 A/G cg05507819 chr15:63340323 TPM1 0.51 6.11 0.35 3.45e-9 Platelet count; CESC cis rs7927771 0.524 rs10838784 chr11:47882341 G/A cg20307385 chr11:47447363 PSMC3 0.61 8.6 0.47 7.14e-16 Subjective well-being; CESC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.23 0.41 5.15e-12 Bipolar disorder; CESC cis rs11608355 0.515 rs4766606 chr12:109934390 C/G cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs2228479 0.850 rs62054640 chr16:89823157 C/T cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC trans rs875971 0.929 rs778692 chr7:65872449 A/G cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.77e-9 Aortic root size; CESC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg11764359 chr7:65958608 NA 0.81 11.89 0.59 2.11e-26 Aortic root size; CESC cis rs28489187 0.617 rs233068 chr1:85805355 G/A cg16011679 chr1:85725395 C1orf52 0.45 5.33 0.31 2.12e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4727027 0.645 rs12704072 chr7:148904888 G/A cg23158103 chr7:148848205 ZNF398 -0.32 -5.09 -0.3 6.8e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs8067354 0.789 rs4622571 chr17:57884397 T/A cg02344993 chr17:57696989 CLTC 0.47 6.17 0.35 2.48e-9 Hemoglobin concentration; CESC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg07167872 chr1:205819463 PM20D1 -0.68 -9.7 -0.51 3.01e-19 Menarche (age at onset); CESC cis rs30380 0.632 rs26495 chr5:96137840 A/G cg16492584 chr5:96139282 ERAP1 -0.48 -6.78 -0.38 7.83e-11 Cerebrospinal fluid biomarker levels; CESC trans rs7937682 0.889 rs521155 chr11:111492563 G/A cg18187862 chr3:45730750 SACM1L 0.48 6.01 0.35 6.26e-9 Primary sclerosing cholangitis; CESC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg07701084 chr6:150067640 NUP43 0.47 6.62 0.38 1.97e-10 Lung cancer; CESC trans rs7726839 0.540 rs7434 chr5:660804 A/G cg25482853 chr8:67687455 SGK3 -0.97 -10.01 -0.52 3.3e-20 Obesity-related traits; CESC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Urate levels; CESC cis rs7116495 0.609 rs2852365 chr11:71715218 T/C cg10381502 chr11:71823885 C11orf51 -1.16 -7.97 -0.44 4.69e-14 Severe influenza A (H1N1) infection; CESC cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg21573476 chr21:45109991 RRP1B -0.53 -8.02 -0.44 3.38e-14 Mean corpuscular volume; CESC cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg15506890 chr2:3487001 NA -0.49 -6.19 -0.36 2.34e-9 Neurofibrillary tangles; CESC cis rs9308433 0.529 rs904321 chr1:214506550 G/C cg06198575 chr1:214491504 SMYD2 0.48 5.63 0.33 4.51e-8 IgG glycosylation; CESC trans rs7672847 0.547 rs6829406 chr4:170394024 C/T cg19308436 chr1:237949471 RYR2 0.6 6.48 0.37 4.45e-10 Subjective well-being; CESC cis rs962856 0.897 rs7579304 chr2:67611250 G/A cg09028215 chr2:67624308 ETAA1 -0.38 -5.06 -0.3 7.7e-7 Pancreatic cancer; CESC cis rs425277 0.565 rs3128293 chr1:2065339 A/G cg16545954 chr1:2118288 C1orf86 -0.35 -6.51 -0.37 3.82e-10 Height; CESC trans rs7246657 0.882 rs6508719 chr19:37877419 A/G cg24637308 chr11:6592297 DNHD1 0.53 6.16 0.35 2.67e-9 Coronary artery calcification; CESC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg19318889 chr4:1322082 MAEA 0.39 5.07 0.3 7.4e-7 Longevity; CESC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg10691866 chr7:65817282 TPST1 0.31 5.24 0.31 3.34e-7 Aortic root size; CESC cis rs2014572 0.510 rs8111661 chr19:57752326 C/G cg24459738 chr19:57751996 ZNF805 0.55 8.06 0.44 2.62e-14 Hyperactive-impulsive symptoms; CESC trans rs11098499 0.863 rs1552092 chr4:120488496 C/T cg25214090 chr10:38739885 LOC399744 0.66 8.96 0.48 5.92e-17 Corneal astigmatism; CESC cis rs920590 0.758 rs7010174 chr8:19661930 G/C cg03894339 chr8:19674705 INTS10 0.63 7.26 0.41 4.24e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.72 0.62 2.88e-29 Alzheimer's disease; CESC cis rs27434 0.602 rs2927620 chr5:96181297 G/A cg16492584 chr5:96139282 ERAP1 -0.53 -6.51 -0.37 3.69e-10 Ankylosing spondylitis; CESC trans rs877282 0.945 rs10904556 chr10:789429 A/G cg22713356 chr15:30763199 NA 1.31 13.31 0.63 2.78e-31 Uric acid levels; CESC cis rs400736 0.894 rs172811 chr1:8039949 A/G cg25007680 chr1:8021821 PARK7 0.71 10.28 0.53 4.35e-21 Response to antidepressants and depression; CESC cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg22875332 chr1:76189707 ACADM 0.64 7.7 0.43 2.76e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg23281280 chr6:28129359 ZNF389 0.48 6.57 0.37 2.58e-10 Parkinson's disease; CESC cis rs4253772 0.591 rs6007740 chr22:46654323 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.68 -8.24 -0.45 8.02e-15 LDL cholesterol;Cholesterol, total; CESC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.02 0.4 1.82e-11 Bipolar disorder; CESC cis rs854765 0.647 rs854767 chr17:18018263 A/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.77 -0.47 2.27e-16 Total body bone mineral density; CESC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg12311346 chr5:56204834 C5orf35 -0.72 -8.86 -0.48 1.15e-16 Initial pursuit acceleration; CESC cis rs12477438 0.520 rs6708576 chr2:99801308 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.09 0.68 1.43e-37 Chronic sinus infection; CESC cis rs2625529 0.652 rs8040216 chr15:72255249 C/T cg16672083 chr15:72433130 SENP8 0.39 5.89 0.34 1.17e-8 Red blood cell count; CESC cis rs4975616 0.869 rs370348 chr5:1331219 A/G cg07493874 chr5:1342172 CLPTM1L -0.41 -7.93 -0.44 6.13e-14 Lung cancer; CESC cis rs4803468 1.000 rs11670757 chr19:41913431 G/T cg14132834 chr19:41945861 ATP5SL -0.58 -7.23 -0.41 5.07e-12 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08631890 chr19:39902969 PLEKHG2 -0.6 -7.36 -0.41 2.32e-12 Gut microbiome composition (summer); CESC cis rs4919694 0.901 rs113541728 chr10:104716771 A/T cg04362960 chr10:104952993 NT5C2 0.78 6.79 0.38 7.53e-11 Arsenic metabolism; CESC cis rs7208859 0.673 rs216424 chr17:28943064 T/G cg17105886 chr17:28927953 LRRC37B2 0.65 5.64 0.33 4.37e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.15 -0.3 5.12e-7 Life satisfaction; CESC cis rs10851478 0.872 rs17402115 chr15:49824761 C/T cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs7917772 0.512 rs11594073 chr10:104308193 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.39 -5.34 -0.31 2.02e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.56 -5.92 -0.34 1.01e-8 Schizophrenia; CESC cis rs10876993 0.928 rs10082911 chr12:58104104 C/A cg18357645 chr12:58087776 OS9 0.63 10.47 0.54 1.11e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs2066819 0.786 rs116934693 chr12:56696545 T/G cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs6061231 0.544 rs2427314 chr20:60973666 C/T cg22541963 chr20:60982533 CABLES2 0.54 6.71 0.38 1.21e-10 Colorectal cancer; CESC cis rs1023500 0.505 rs134886 chr22:42673856 C/T cg04733989 chr22:42467013 NAGA -0.59 -8.82 -0.48 1.6e-16 Schizophrenia; CESC cis rs892961 0.836 rs8071497 chr17:75414358 T/C cg05865280 chr17:75406074 SEPT9 0.63 12.77 0.62 1.96e-29 Airflow obstruction; CESC cis rs5750830 0.594 rs6001568 chr22:39775786 G/A cg24399712 chr22:39784796 NA -0.83 -11.45 -0.58 6.44e-25 Intelligence (multi-trait analysis); CESC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg16325326 chr1:53192061 ZYG11B 0.82 13.08 0.63 1.64e-30 Monocyte count; CESC cis rs11122272 0.705 rs2808599 chr1:231533482 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05147070 chr3:160283469 KPNA4 0.63 7.35 0.41 2.41e-12 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs2755246 chr1:67488984 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.92 11.85 0.59 2.84e-26 Lymphocyte percentage of white cells; CESC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg03188948 chr7:1209495 NA 0.7 7.7 0.43 2.64e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9291683 0.609 rs13141233 chr4:10028729 T/C cg02734326 chr4:10020555 SLC2A9 0.47 6.52 0.37 3.47e-10 Bone mineral density; CESC cis rs13720 0.722 rs163801 chr20:57578614 A/G cg23907860 chr20:57583709 CTSZ -0.47 -5.7 -0.33 3.11e-8 Platelet distribution width; CESC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg04944784 chr2:26401820 FAM59B -0.8 -8.93 -0.48 7.17e-17 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15537487 chr10:1043368 GTPBP4 -0.58 -6.82 -0.39 6e-11 Gut microbiome composition (summer); CESC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg02221750 chr19:17393354 ANKLE1 -0.52 -6.29 -0.36 1.32e-9 Systemic lupus erythematosus; CESC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg21724239 chr8:58056113 NA 0.56 5.78 0.33 2.13e-8 Developmental language disorder (linguistic errors); CESC cis rs14978 0.628 rs4721060 chr7:12267552 G/A cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.58e-7 Response to amphetamines; CESC cis rs6693567 0.545 rs2275246 chr1:150460168 A/G cg09579323 chr1:150459698 TARS2 0.46 5.75 0.33 2.4e-8 Migraine; CESC cis rs11252926 0.527 rs11252754 chr10:538637 G/A cg16386425 chr10:429943 DIP2C -0.45 -5.73 -0.33 2.66e-8 Psychosis in Alzheimer's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00903375 chr7:66460591 SBDS;TYW1 -0.47 -6.75 -0.38 9.03e-11 Gambling; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22153931 chr7:43917675 URGCP 0.5 6.83 0.39 5.85e-11 Fibrinogen levels; CESC cis rs6681460 0.966 rs10889644 chr1:67145322 C/A cg02459107 chr1:67143332 SGIP1 0.37 5.09 0.3 6.76e-7 Presence of antiphospholipid antibodies; CESC trans rs1728785 0.591 rs10775305 chr16:68656460 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 7.7 0.43 2.73e-13 Ulcerative colitis; CESC cis rs4319547 0.737 rs7964138 chr12:122950375 A/G cg23029597 chr12:123009494 RSRC2 -0.45 -5.15 -0.3 5.14e-7 Body mass index; CESC trans rs6987853 0.830 rs12542919 chr8:42356035 C/T cg27650678 chr11:66636318 PC -0.46 -6.11 -0.35 3.45e-9 Mean corpuscular hemoglobin concentration; CESC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 9.97 0.52 4.3e-20 Prudent dietary pattern; CESC cis rs2180341 0.782 rs4487601 chr6:127723521 A/G cg24812749 chr6:127587940 RNF146 0.83 12.07 0.6 5.14e-27 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07241146 chr10:134145514 LRRC27 -0.54 -6.11 -0.35 3.56e-9 Gut microbiome composition (summer); CESC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg14558114 chr2:88469736 THNSL2 0.58 5.53 0.32 7.83e-8 Plasma clusterin levels; CESC cis rs7091068 0.671 rs604489 chr10:95405408 T/C cg20715218 chr10:95462985 C10orf4 -0.51 -5.37 -0.31 1.76e-7 Urinary tract infection frequency; CESC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg12463550 chr7:65579703 CRCP -0.54 -6.65 -0.38 1.65e-10 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01085995 chr3:47866817 DHX30 0.59 6.56 0.37 2.83e-10 Gut microbiome composition (summer); CESC cis rs11958404 0.932 rs6884954 chr5:157436772 C/T cg05962755 chr5:157440814 NA 0.6 6.38 0.36 7.98e-10 IgG glycosylation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26818010 chr10:134567672 INPP5A 0.56 7.32 0.41 3.05e-12 Fibrinogen levels; CESC cis rs763121 0.853 rs7289855 chr22:39042221 G/T cg14440974 chr22:39074834 NA -0.42 -5.64 -0.33 4.24e-8 Menopause (age at onset); CESC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg26335602 chr6:28129616 ZNF389 0.38 5.53 0.32 7.72e-8 Cardiac Troponin-T levels; CESC cis rs1008375 1.000 rs555 chr4:17625658 A/G cg04450456 chr4:17643702 FAM184B 0.37 5.32 0.31 2.26e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.1 0.3 6.52e-7 Hip circumference adjusted for BMI; CESC cis rs4237845 0.537 rs10877031 chr12:58266695 A/G cg00677455 chr12:58241039 CTDSP2 0.8 10.71 0.55 1.76e-22 Intelligence (multi-trait analysis); CESC cis rs11098499 0.866 rs6824111 chr4:120285968 T/A cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs1153858 0.668 rs63603561 chr15:45593323 T/A cg21132104 chr15:45694354 SPATA5L1 -0.81 -10.19 -0.53 8.51e-21 Homoarginine levels; CESC cis rs1728785 1.000 rs1099296 chr16:68588653 G/A cg02972257 chr16:68554789 NA -0.58 -6.68 -0.38 1.42e-10 Ulcerative colitis; CESC cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg02487422 chr3:49467188 NICN1 0.48 6.04 0.35 5.3300000000000004e-09 Parkinson's disease; CESC trans rs4332037 0.539 rs56016347 chr7:2060126 C/T cg11693508 chr17:37793320 STARD3 0.66 6.63 0.38 1.84e-10 Bipolar disorder; CESC cis rs6693567 0.516 rs519126 chr1:150288859 T/G cg09579323 chr1:150459698 TARS2 -0.46 -6.02 -0.35 5.85e-9 Migraine; CESC cis rs35123781 0.654 rs356486 chr5:139085103 C/G cg10513866 chr5:139070639 NA -0.41 -5.61 -0.33 5.16e-8 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10165071 chr2:217557160 IGFBP5 -0.45 -6.54 -0.37 3.11e-10 Gut microbiota (bacterial taxa); CESC cis rs7605827 0.930 rs3815597 chr2:15625404 T/C cg19274914 chr2:15703543 NA 0.37 6.63 0.38 1.85e-10 Educational attainment (years of education); CESC cis rs1538970 0.924 rs12046816 chr1:45891543 G/T cg03146154 chr1:46216737 IPP 0.44 5.09 0.3 6.74e-7 Platelet count; CESC cis rs4660306 1.000 rs10736426 chr1:45984353 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 6.79 0.39 7.22e-11 Homocysteine levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04167064 chr1:46932305 NA -0.48 -6.56 -0.37 2.77e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs644799 1.000 rs10831431 chr11:95510089 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.89 0.39 4.06e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg13798912 chr7:905769 UNC84A -0.56 -5.53 -0.32 7.82e-8 Cerebrospinal P-tau181p levels; CESC cis rs796364 1.000 rs769950 chr2:200730028 A/G cg23649088 chr2:200775458 C2orf69 0.54 5.1 0.3 6.38e-7 Schizophrenia; CESC cis rs722599 0.748 rs20578 chr14:75367807 C/T cg08847533 chr14:75593920 NEK9 -0.47 -5.62 -0.33 4.89e-8 IgG glycosylation; CESC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC trans rs7824557 0.564 rs1435275 chr8:11235735 T/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.15 -0.35 2.9e-9 Retinal vascular caliber; CESC trans rs11098499 0.644 rs17517414 chr4:120262101 G/C cg25214090 chr10:38739885 LOC399744 0.6 8.47 0.46 1.65e-15 Corneal astigmatism; CESC trans rs11098499 1.000 rs28374891 chr4:120183550 G/A cg25214090 chr10:38739885 LOC399744 0.64 8.57 0.47 8.75e-16 Corneal astigmatism; CESC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg04772025 chr11:68637568 NA 0.5 6.17 0.35 2.5e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg15112475 chr7:1198522 ZFAND2A -0.4 -6.23 -0.36 1.8e-9 Longevity;Endometriosis; CESC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg04369109 chr6:150039330 LATS1 -0.4 -5.4 -0.31 1.48e-7 Lung cancer; CESC cis rs6502050 0.761 rs11653003 chr17:80058795 G/T cg23985595 chr17:80112537 CCDC57 0.42 6.25 0.36 1.64e-9 Life satisfaction; CESC cis rs4253772 0.744 rs4253760 chr22:46622384 T/G cg09491104 chr22:46646882 C22orf40 -0.6 -8.87 -0.48 1.14e-16 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23268322 chr19:50762551 MYH14 -0.56 -6.19 -0.36 2.3e-9 Gut microbiome composition (summer); CESC cis rs826838 0.935 rs10875816 chr12:38955014 C/A cg26384229 chr12:38710491 ALG10B 0.83 14.68 0.67 4.21e-36 Heart rate; CESC cis rs1559088 0.842 rs12977993 chr19:33580453 T/A cg27124370 chr19:33622961 WDR88 0.48 6.33 0.36 1.06e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg07952391 chr2:88470173 THNSL2 0.62 5.87 0.34 1.27e-8 Plasma clusterin levels; CESC cis rs2072499 0.750 rs10159384 chr1:156160822 C/T cg25208724 chr1:156163844 SLC25A44 1.01 12.84 0.62 1.13e-29 Testicular germ cell tumor; CESC trans rs9858542 1.000 rs9822268 chr3:49719729 G/A cg21659725 chr3:3221576 CRBN -0.54 -6.71 -0.38 1.21e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs752010 0.714 rs6600384 chr1:42085141 A/G cg06885757 chr1:42089581 HIVEP3 -0.51 -8.92 -0.48 8e-17 Lupus nephritis in systemic lupus erythematosus; CESC cis rs6598955 0.756 rs10902723 chr1:26568542 T/C cg00852783 chr1:26633632 UBXN11 0.42 6.22 0.36 1.89e-9 Obesity-related traits; CESC trans rs11039798 0.841 rs11500573 chr11:48713900 T/G cg15704280 chr7:45808275 SEPT13 0.7 6.42 0.37 6.38e-10 Axial length; CESC cis rs9914988 0.778 rs9907192 chr17:27122426 C/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs11958404 0.932 rs72818104 chr5:157437632 T/C cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg17372223 chr3:52568218 NT5DC2 0.43 6.06 0.35 4.63e-9 Bipolar disorder; CESC cis rs472402 0.623 rs8192130 chr5:6636450 G/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.53 -7.0 -0.4 2.06e-11 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06110221 chr11:64257582 NA 0.42 6.0 0.35 6.59e-9 Gut microbiome composition (summer); CESC cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg11752832 chr7:134001865 SLC35B4 0.51 6.52 0.37 3.54e-10 Mean platelet volume; CESC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg07677032 chr17:61819896 STRADA 0.44 5.81 0.34 1.81e-8 Prudent dietary pattern; CESC cis rs2011503 1.000 rs756999 chr19:19448200 A/G cg11584989 chr19:19387371 SF4 -0.63 -7.55 -0.42 7.15e-13 Bipolar disorder; CESC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg22143856 chr6:28129313 ZNF389 0.46 5.83 0.34 1.58e-8 Depression; CESC cis rs892961 0.899 rs72896163 chr17:75412525 C/T cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC trans rs5756813 0.754 rs11089854 chr22:38148882 G/A cg19894588 chr14:64061835 NA -0.66 -7.97 -0.44 4.62e-14 Optic cup area;Vertical cup-disc ratio; CESC cis rs35110281 0.659 rs11909064 chr21:45092095 G/C cg04455712 chr21:45112962 RRP1B 0.49 7.47 0.42 1.14e-12 Mean corpuscular volume; CESC cis rs2243480 0.901 rs34807232 chr7:65965133 G/A cg18252515 chr7:66147081 NA -1.4 -14.3 -0.66 9.14e-35 Diabetic kidney disease; CESC cis rs6662572 0.950 rs56093189 chr1:46234323 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 5.58 0.32 6e-8 Blood protein levels; CESC cis rs7246657 0.943 rs6508711 chr19:37815134 G/T cg23950597 chr19:37808831 NA -0.55 -6.04 -0.35 5.24e-9 Coronary artery calcification; CESC cis rs8027181 0.682 rs890354 chr15:73100924 C/G cg25632853 chr15:73088954 NA 0.31 5.68 0.33 3.52e-8 Triglyceride levels; CESC cis rs9611565 0.525 rs9611549 chr22:41705909 C/G cg17376030 chr22:41985996 PMM1 0.48 5.38 0.31 1.6e-7 Vitiligo; CESC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.05 0.8 6.51e-62 Prudent dietary pattern; CESC cis rs6964587 0.692 rs10227225 chr7:91571074 A/G cg17063962 chr7:91808500 NA -0.45 -6.32 -0.36 1.13e-9 Breast cancer; CESC cis rs3733585 0.631 rs4697925 chr4:10124330 G/C cg00071950 chr4:10020882 SLC2A9 -0.64 -9.63 -0.51 5.27e-19 Cleft plate (environmental tobacco smoke interaction); CESC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg12963246 chr6:28129442 ZNF389 0.56 7.4 0.41 1.8e-12 Depression; CESC cis rs12477438 0.798 rs13412764 chr2:99583733 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.22 -0.53 6.79e-21 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09414045 chr1:110162465 AMPD2 0.56 6.43 0.37 6.08e-10 Gut microbiome composition (summer); CESC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg10578991 chr7:12443926 VWDE -0.49 -6.22 -0.36 1.91e-9 Coronary artery disease; CESC cis rs2795502 0.882 rs2744087 chr10:43340270 A/C cg27426351 chr10:43362370 NA -0.45 -5.5 -0.32 8.91e-8 Blood protein levels; CESC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC cis rs2625529 0.816 rs4777467 chr15:72138478 T/C cg16672083 chr15:72433130 SENP8 -0.4 -5.18 -0.3 4.47e-7 Red blood cell count; CESC cis rs7927592 0.626 rs11228279 chr11:68309680 C/T cg20283391 chr11:68216788 NA 0.43 5.38 0.31 1.67e-7 Total body bone mineral density; CESC cis rs965469 0.817 rs16988490 chr20:3335431 C/T cg25506879 chr20:3388711 C20orf194 0.53 5.59 0.32 5.53e-8 IFN-related cytopenia; CESC cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.67 6.37 0.36 8.09e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3806843 1.000 rs991918 chr5:140194858 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.25 -0.31 3.19e-7 Depressive symptoms (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26020522 chr12:105629518 APPL2 0.56 6.02 0.35 5.66e-9 Gut microbiome composition (summer); CESC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg08704250 chr15:31115839 NA -0.63 -8.12 -0.45 1.8e-14 Huntington's disease progression; CESC trans rs8026198 0.568 rs1678984 chr15:42616332 T/G cg19625216 chr1:249132108 ZNF672 -0.72 -5.99 -0.35 6.68e-9 Fibrinogen levels; CESC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg08704250 chr15:31115839 NA 0.69 9.36 0.5 3.56e-18 Huntington's disease progression; CESC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg15383120 chr6:291909 DUSP22 -0.67 -8.63 -0.47 5.92e-16 Menopause (age at onset); CESC cis rs1878931 0.501 rs42329 chr16:3425524 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.67 -8.42 -0.46 2.42e-15 Body mass index (adult); CESC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.87 0.34 1.27e-8 Tonsillectomy; CESC cis rs2836633 0.965 rs2836621 chr21:40054149 C/T cg05519781 chr21:40033154 ERG 0.6 9.25 0.49 7.96e-18 Coronary artery disease; CESC cis rs6088580 0.634 rs6058073 chr20:33116483 T/C cg08999081 chr20:33150536 PIGU 0.65 11.2 0.57 4.19e-24 Glomerular filtration rate (creatinine); CESC trans rs74054849 0.850 rs72878850 chr1:16004612 A/G cg06826283 chr7:600452 PRKAR1B 0.71 6.12 0.35 3.3e-9 Alcoholic chronic pancreatitis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24484856 chr12:69140014 SLC35E3 -0.49 -6.39 -0.37 7.27e-10 Asthma; CESC cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg15017067 chr4:17643749 FAM184B 0.38 5.45 0.32 1.16e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4920343 0.890 rs4920531 chr1:19095746 A/G cg19637330 chr1:19110922 NA -0.37 -5.16 -0.3 4.82e-7 Knee osteoarthritis; CESC cis rs2108622 0.958 rs56340170 chr19:15981877 G/C cg13772218 chr19:15982569 NA 0.38 7.14 0.4 8.98e-12 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.95 -0.34 8.33e-9 Total body bone mineral density; CESC cis rs2658782 0.789 rs2658775 chr11:93126799 C/T cg15737290 chr11:93063684 CCDC67 0.49 6.14 0.35 3.01e-9 Pulmonary function decline; CESC cis rs1059312 0.966 rs12368452 chr12:129277164 C/A cg09035930 chr12:129282057 SLC15A4 0.75 10.45 0.54 1.28e-21 Systemic lupus erythematosus; CESC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg27170947 chr2:26402098 FAM59B -0.82 -9.69 -0.51 3.38e-19 Gut microbiome composition (summer); CESC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg03647317 chr4:187891568 NA 0.36 5.26 0.31 3.03e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs2997447 0.688 rs17257100 chr1:26439586 C/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs7633857 0.532 rs1580254 chr3:160767278 C/T cg03342759 chr3:160939853 NMD3 -0.44 -5.86 -0.34 1.4e-8 Educational attainment (years of education); CESC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg24250549 chr1:154909240 PMVK 0.71 10.26 0.53 5.23e-21 Prostate cancer; CESC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.77 10.33 0.54 3.13e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2228479 0.702 rs62056100 chr16:89939753 C/T cg04013166 chr16:89971882 TCF25 0.77 6.46 0.37 4.98e-10 Skin colour saturation; CESC cis rs4654899 1.000 rs6689819 chr1:21472395 A/T cg05370193 chr1:21551575 ECE1 0.41 6.2 0.36 2.2e-9 Superior frontal gyrus grey matter volume; CESC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg05332525 chr7:65337924 VKORC1L1 0.51 6.4 0.37 7.15e-10 Aortic root size; CESC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg04414720 chr1:150670196 GOLPH3L -0.37 -5.19 -0.3 4.19e-7 Tonsillectomy; CESC cis rs796364 0.806 rs11688168 chr2:200916004 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs7582720 1.000 rs72934715 chr2:203713280 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.82 6.88 0.39 4.21e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs9858542 0.953 rs12330269 chr3:49513910 G/A cg21659725 chr3:3221576 CRBN -0.55 -6.49 -0.37 4.22e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg04166393 chr7:2884313 GNA12 0.58 7.02 0.4 1.89e-11 Height; CESC cis rs10129255 0.536 rs10142951 chr14:107190574 A/G cg07958169 chr14:107095056 NA -0.53 -8.25 -0.45 7.29e-15 Kawasaki disease; CESC cis rs2073300 0.609 rs74273791 chr20:23418067 A/T cg12062639 chr20:23401060 NAPB 1.04 8.1 0.45 1.97e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6831352 0.879 rs17218003 chr4:100054723 G/C cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs1568889 1.000 rs7937778 chr11:28104605 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.83 0.55 7.35e-23 Bipolar disorder; CESC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.15 0.4 8.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6714710 0.603 rs6746768 chr2:98466647 C/T cg26665480 chr2:98280029 ACTR1B 0.57 8.04 0.44 3.03e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs6142102 0.625 rs6141432 chr20:32548597 A/G cg08999081 chr20:33150536 PIGU 0.34 5.11 0.3 6.04e-7 Skin pigmentation; CESC cis rs5758511 0.689 rs62240864 chr22:42563889 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.57 -5.12 -0.3 5.88e-7 Birth weight; CESC cis rs921968 0.565 rs1541777 chr2:219587291 A/G cg02176678 chr2:219576539 TTLL4 -0.43 -7.59 -0.42 5.51e-13 Mean corpuscular hemoglobin concentration; CESC cis rs55883249 0.957 rs10495572 chr2:9734859 C/G cg23886495 chr2:9695866 ADAM17 -0.52 -5.19 -0.3 4.13e-7 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs13106227 0.550 rs1949137 chr4:77387997 C/G cg20311846 chr4:77356250 SHROOM3 -0.32 -5.78 -0.33 2.12e-8 Eosinophilic esophagitis (pediatric); CESC cis rs1124769 0.871 rs17646461 chr15:51158110 C/T cg21246271 chr15:51200259 AP4E1 -0.54 -5.14 -0.3 5.29e-7 Cognitive performance; CESC cis rs2576037 0.901 rs2060416 chr18:44576240 G/C cg19077165 chr18:44547161 KATNAL2 0.55 8.0 0.44 4.02e-14 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16554516 chr1:206680868 RASSF5 0.52 6.13 0.35 3.11e-9 Gut microbiome composition (summer); CESC cis rs4803468 1.000 rs3816037 chr19:41918009 C/T cg14132834 chr19:41945861 ATP5SL -0.58 -7.23 -0.41 5.22e-12 Height; CESC cis rs4888262 0.564 rs8062404 chr16:74611675 T/C cg01733217 chr16:74700730 RFWD3 0.83 11.46 0.58 5.96e-25 Testicular germ cell tumor; CESC cis rs3820928 0.874 rs2177594 chr2:227836239 C/G cg11843606 chr2:227700838 RHBDD1 -0.44 -5.69 -0.33 3.29e-8 Pulmonary function; CESC cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg21573476 chr21:45109991 RRP1B -0.37 -5.22 -0.31 3.65e-7 Mean corpuscular volume; CESC cis rs765787 0.530 rs4775834 chr15:45537511 C/T cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs2835872 0.758 rs1709817 chr21:39036349 T/A cg06728970 chr21:39037746 KCNJ6 0.3 5.53 0.32 7.57e-8 Electroencephalographic traits in alcoholism; CESC cis rs67311347 0.911 rs9849224 chr3:40392562 T/C cg09455208 chr3:40491958 NA 0.46 8.07 0.44 2.45e-14 Renal cell carcinoma; CESC cis rs1570884 0.516 rs2094108 chr13:50171550 G/A cg03651054 chr13:50194643 NA 0.31 5.08 0.3 7.07e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC trans rs13398848 1.000 rs10496303 chr2:84210246 C/A cg23262351 chr6:79576851 IRAK1BP1 -0.69 -6.08 -0.35 4.1e-9 Conduct disorder (symptom count);Conduct disorder; CESC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.49 6.93 0.39 3.16e-11 Menopause (age at onset); CESC cis rs12930096 0.938 rs12444653 chr16:11677955 A/C cg07439791 chr16:11680400 LITAF 0.63 5.76 0.33 2.31e-8 QT interval; CESC cis rs2280018 1.000 rs2280018 chr16:15150833 A/C cg07549590 chr16:15018862 NA -0.49 -7.98 -0.44 4.41e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg26665246 chr5:179105570 CBY3 0.5 6.12 0.35 3.36e-9 Psoriatic arthritis; CESC cis rs10927875 0.691 rs1048302 chr1:16340879 T/G cg21385522 chr1:16154831 NA 0.59 7.09 0.4 1.24e-11 Dilated cardiomyopathy; CESC cis rs228437 0.802 rs228441 chr6:134899931 C/T cg24504307 chr6:134963096 NA 0.46 5.23 0.31 3.48e-7 Melanoma; CESC cis rs2290159 0.800 rs11709504 chr3:12674199 T/C cg23032965 chr3:12705835 RAF1 0.53 5.67 0.33 3.76e-8 Cholesterol, total; CESC cis rs2066819 1.000 rs59811639 chr12:56695954 C/T cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg07507251 chr3:52567010 NT5DC2 0.32 5.61 0.33 5.12e-8 Bipolar disorder; CESC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg10560079 chr2:191398806 TMEM194B 0.48 6.93 0.39 3.2e-11 Pulse pressure; CESC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC cis rs7264396 0.511 rs2425102 chr20:34312303 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.75 -0.55 1.33e-22 Total cholesterol levels; CESC cis rs4481887 0.893 rs11204632 chr1:248479532 G/A cg00666640 chr1:248458726 OR2T12 0.34 5.32 0.31 2.18e-7 Common traits (Other); CESC cis rs6587515 0.901 rs10788795 chr1:150758047 A/G cg13175981 chr1:150552382 MCL1 0.62 5.23 0.31 3.48e-7 Pericardial adipose tissue adjusted for height and weight; CESC cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg16339924 chr4:17578868 LAP3 0.6 7.47 0.42 1.17e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg08859206 chr1:53392774 SCP2 0.56 7.3 0.41 3.27e-12 Monocyte count; CESC trans rs7246760 1.000 rs28802413 chr19:9901617 T/C cg02900749 chr2:68251473 NA -0.74 -6.84 -0.39 5.62e-11 Pursuit maintenance gain; CESC cis rs1050631 1.000 rs11873168 chr18:33707581 T/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.45 5.8 0.34 1.89e-8 Esophageal squamous cell cancer (length of survival); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08367703 chr9:139304491 SDCCAG3;PMPCA 0.49 6.46 0.37 5.1e-10 Systemic lupus erythematosus; CESC cis rs7582720 1.000 rs72932573 chr2:203861113 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs853679 0.546 rs200990 chr6:27815823 T/G cg06606381 chr12:133084897 FBRSL1 -0.78 -7.42 -0.41 1.63e-12 Depression; CESC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.78 0.62 1.87e-29 Colonoscopy-negative controls vs population controls; CESC trans rs7819412 1.000 rs7819412 chr8:11045161 A/G cg06636001 chr8:8085503 FLJ10661 0.51 6.46 0.37 5.11e-10 Triglycerides; CESC cis rs3126085 0.673 rs3126089 chr1:152306187 T/A cg03465714 chr1:152285911 FLG 0.43 5.22 0.31 3.62e-7 Atopic dermatitis; CESC cis rs910316 1.000 rs4899546 chr14:75594946 G/C cg08847533 chr14:75593920 NEK9 1.0 19.1 0.76 9.46e-52 Height; CESC cis rs7586879 0.681 rs6545800 chr2:25118885 A/G cg01884057 chr2:25150051 NA -0.36 -6.99 -0.39 2.21e-11 Body mass index; CESC cis rs1681630 0.545 rs12790666 chr11:47983477 G/A cg18512352 chr11:47633146 NA -0.37 -5.82 -0.34 1.68e-8 Height; CESC cis rs2439831 0.850 rs12441984 chr15:44126285 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.58 0.32 5.87e-8 Lung cancer in ever smokers; CESC cis rs9790314 0.846 rs4290817 chr3:160967354 G/A cg03342759 chr3:160939853 NMD3 -0.51 -7.39 -0.41 1.96e-12 Morning vs. evening chronotype; CESC cis rs7084402 0.967 rs1658489 chr10:60285924 A/G cg07615347 chr10:60278583 BICC1 0.59 9.44 0.5 2.04e-18 Refractive error; CESC trans rs116095464 0.558 rs9312979 chr5:222057 A/C cg00938859 chr5:1591904 SDHAP3 0.66 6.24 0.36 1.72e-9 Breast cancer; CESC cis rs763121 0.962 rs1980455 chr22:38925719 A/C cg06022373 chr22:39101656 GTPBP1 0.77 12.05 0.59 5.87e-27 Menopause (age at onset); CESC cis rs7666738 0.606 rs6852813 chr4:99084671 G/A cg17366294 chr4:99064904 C4orf37 0.43 5.77 0.33 2.15e-8 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg11764359 chr7:65958608 NA 0.96 15.06 0.68 1.89e-37 Aortic root size; CESC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg10243787 chr22:19419481 HIRA;MRPL40 -0.47 -6.15 -0.35 2.8e-9 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg05617927 chr15:83654886 FAM103A1 0.51 6.11 0.35 3.52e-9 Endometrial cancer; CESC trans rs208520 0.731 rs12206488 chr6:66999917 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 8.87 0.48 1.11e-16 Exhaled nitric oxide output; CESC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg25072359 chr17:41440525 NA 0.45 6.13 0.35 3.21e-9 Menopause (age at onset); CESC cis rs9858542 0.953 rs34363169 chr3:49537712 G/A cg03060546 chr3:49711283 APEH -0.54 -6.12 -0.35 3.44e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg24675658 chr1:53192096 ZYG11B 0.54 7.46 0.42 1.2e-12 Monocyte count; CESC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg01516881 chr6:292596 DUSP22 -0.52 -6.81 -0.39 6.34e-11 Menopause (age at onset); CESC cis rs13256369 0.755 rs11776987 chr8:8559401 C/G cg18904891 chr8:8559673 CLDN23 0.72 7.96 0.44 4.94e-14 Obesity-related traits; CESC cis rs2236918 1.000 rs2236919 chr1:242017731 A/G cg17736920 chr1:242011382 EXO1 0.74 10.22 0.53 6.83e-21 Menopause (age at onset); CESC cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg00701064 chr4:6280414 WFS1 0.54 8.05 0.44 2.73e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg00677455 chr12:58241039 CTDSP2 0.52 6.55 0.37 3.04e-10 Multiple sclerosis; CESC cis rs10242455 0.867 rs776742 chr7:99292755 C/T cg07715041 chr7:99302981 CYP3A7 0.44 5.56 0.32 6.73e-8 Blood metabolite levels; CESC cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg23018236 chr17:30244563 NA -0.53 -5.14 -0.3 5.32e-7 Hip circumference adjusted for BMI; CESC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg22968622 chr17:43663579 NA 1.3 18.06 0.74 4.28e-48 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg27165867 chr14:105738592 BRF1 -0.52 -5.57 -0.32 6.41e-8 Mean platelet volume;Platelet distribution width; CESC cis rs3806843 1.000 rs3806845 chr5:140180737 C/T cg26395211 chr5:140044315 WDR55 -0.41 -5.12 -0.3 5.95e-7 Depressive symptoms (multi-trait analysis); CESC cis rs11690935 1.000 rs6433311 chr2:172549248 A/G cg13550731 chr2:172543902 DYNC1I2 1.0 16.64 0.71 4.76e-43 Schizophrenia; CESC cis rs7520050 0.931 rs11211189 chr1:46261584 A/T cg24296786 chr1:45957014 TESK2 0.44 5.54 0.32 7.17e-8 Red blood cell count;Reticulocyte count; CESC cis rs12142240 1.000 rs12142240 chr1:46747301 T/C cg00530320 chr1:46809349 NSUN4 0.55 6.87 0.39 4.56e-11 Menopause (age at onset); CESC cis rs3768617 0.811 rs34721094 chr1:183051521 T/C ch.1.3577855R chr1:183094577 LAMC1 0.67 9.27 0.49 6.9e-18 Fuchs's corneal dystrophy; CESC cis rs67478160 0.643 rs4906369 chr14:104242458 T/C cg08213375 chr14:104286397 PPP1R13B 0.55 11.0 0.56 1.99e-23 Schizophrenia; CESC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg18252515 chr7:66147081 NA 0.45 5.97 0.34 7.65e-9 Aortic root size; CESC cis rs7927771 0.524 rs10838758 chr11:47771476 T/C cg20307385 chr11:47447363 PSMC3 0.61 8.59 0.47 7.41e-16 Subjective well-being; CESC cis rs11785400 0.753 rs9773415 chr8:143731170 G/A cg24634471 chr8:143751801 JRK 0.45 5.68 0.33 3.51e-8 Schizophrenia; CESC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg09455208 chr3:40491958 NA 0.49 8.1 0.45 1.99e-14 Renal cell carcinoma; CESC cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.21e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11608355 0.515 rs61941631 chr12:109935475 C/T cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.68 10.01 0.52 3.25e-20 Menarche (age at onset); CESC cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg14345882 chr6:26364793 BTN3A2 0.43 5.14 0.3 5.39e-7 Intelligence (multi-trait analysis); CESC cis rs727563 0.608 rs2076200 chr22:41985956 G/T cg17376030 chr22:41985996 PMM1 0.81 8.45 0.46 1.98e-15 Crohn's disease;Inflammatory bowel disease; CESC cis rs7772486 0.790 rs9497431 chr6:146248177 T/C cg23711669 chr6:146136114 FBXO30 -0.93 -13.61 -0.64 2.34e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.954 rs34858317 chr4:120387110 A/C cg24375607 chr4:120327624 NA 0.44 5.48 0.32 9.91e-8 Corneal astigmatism; CESC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg08027265 chr7:2291960 NA -0.47 -7.24 -0.41 4.97e-12 Bipolar disorder and schizophrenia; CESC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.89 9.95 0.52 4.99e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.42 -6.25 -0.36 1.62e-9 Electroencephalogram traits; CESC cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg26597838 chr10:835615 NA -0.79 -8.98 -0.48 5.17e-17 Eosinophil percentage of granulocytes; CESC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg18404041 chr3:52824283 ITIH1 -0.4 -6.69 -0.38 1.35e-10 Bipolar disorder; CESC cis rs12682352 0.602 rs4841044 chr8:8664940 A/G cg17143192 chr8:8559678 CLDN23 -0.43 -5.26 -0.31 3.01e-7 Neuroticism; CESC cis rs8067354 0.645 rs72840522 chr17:57829992 G/A cg13753209 chr17:57696993 CLTC 0.65 7.89 0.44 7.95e-14 Hemoglobin concentration; CESC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg13770153 chr20:60521292 NA -0.5 -6.53 -0.37 3.31e-10 Body mass index; CESC cis rs2204008 0.837 rs11172728 chr12:38070042 C/A cg13010199 chr12:38710504 ALG10B 0.47 5.79 0.34 2.01e-8 Bladder cancer; CESC cis rs9399135 0.967 rs6923827 chr6:135335382 C/T cg22676075 chr6:135203613 NA 0.5 7.08 0.4 1.31e-11 Red blood cell count; CESC cis rs9300255 0.602 rs1727316 chr12:123618603 C/T cg05973401 chr12:123451056 ABCB9 0.52 5.9 0.34 1.13e-8 Neutrophil percentage of white cells; CESC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg11494091 chr17:61959527 GH2 0.37 5.09 0.3 6.71e-7 Height; CESC cis rs76533333 0.564 rs114940891 chr13:113419784 A/T cg08557188 chr13:113420371 ATP11A -0.75 -5.1 -0.3 6.37e-7 Red cell distribution width; CESC cis rs4253772 0.637 rs9627402 chr22:46702586 C/T cg18190219 chr22:46762943 CELSR1 -0.58 -6.27 -0.36 1.49e-9 LDL cholesterol;Cholesterol, total; CESC cis rs1048238 0.506 rs1262788 chr1:16215608 G/C cg21385522 chr1:16154831 NA -0.45 -5.79 -0.33 2.04e-8 Systolic blood pressure; CESC cis rs4604732 0.589 rs78689516 chr1:247626274 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 10.06 0.53 2.28e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg21782813 chr7:2030301 MAD1L1 0.38 5.36 0.31 1.78e-7 Schizophrenia; CESC cis rs11098499 0.955 rs6815725 chr4:120158410 C/A cg24375607 chr4:120327624 NA 0.43 5.17 0.3 4.57e-7 Corneal astigmatism; CESC cis rs27434 0.583 rs34760 chr5:96153491 T/C cg16492584 chr5:96139282 ERAP1 -0.38 -5.54 -0.32 7.47e-8 Ankylosing spondylitis; CESC cis rs7605827 0.930 rs7577512 chr2:15623218 G/T cg19274914 chr2:15703543 NA 0.38 6.74 0.38 9.95e-11 Educational attainment (years of education); CESC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg02788857 chr8:22132959 PIWIL2 -0.34 -6.13 -0.35 3.15e-9 Hypertriglyceridemia; CESC cis rs56804039 1.000 rs58361948 chr8:8380995 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -5.28 -0.31 2.66e-7 Cervical cancer; CESC cis rs2243480 0.803 rs13224048 chr7:65993766 G/A cg18252515 chr7:66147081 NA -1.4 -14.3 -0.66 9.38e-35 Diabetic kidney disease; CESC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg17724175 chr1:150552817 MCL1 0.41 6.39 0.37 7.27e-10 Melanoma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00905354 chr6:170059414 WDR27 0.45 6.33 0.36 1.03e-9 Fibrinogen levels; CESC cis rs7937682 0.924 rs875257 chr11:111530453 A/G cg22437258 chr11:111473054 SIK2 0.69 9.29 0.5 5.71e-18 Primary sclerosing cholangitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05606039 chr17:73511506 TSEN54;CASKIN2 0.48 6.6 0.38 2.2e-10 Gut microbiota (bacterial taxa); CESC cis rs3813567 0.759 rs7163204 chr15:78953740 G/A cg05914723 chr15:78953907 NA 0.45 5.74 0.33 2.62e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg14262678 chr6:151773367 RMND1;C6orf211 0.66 9.4 0.5 2.72e-18 Menarche (age at onset); CESC cis rs2124969 0.548 rs72979963 chr2:161014483 A/G cg03641300 chr2:160917029 PLA2R1 -0.58 -6.01 -0.35 6.14e-9 Waist circumference adjusted for body mass index; CESC cis rs7208859 0.623 rs56325146 chr17:29151024 T/C cg13385521 chr17:29058706 SUZ12P 0.73 6.0 0.35 6.62e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs684232 0.602 rs331010 chr17:547124 G/A cg12384639 chr17:618140 VPS53 0.41 5.31 0.31 2.36e-7 Prostate cancer; CESC cis rs1729951 0.546 rs12054218 chr3:136677496 C/G cg04103450 chr3:136751342 NA 0.4 5.4 0.31 1.47e-7 Neuroticism; CESC cis rs72945132 0.882 rs7118156 chr11:70142922 T/C cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs2204008 0.748 rs7312204 chr12:38334909 T/C cg13010199 chr12:38710504 ALG10B 0.41 5.26 0.31 2.93e-7 Bladder cancer; CESC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg10691866 chr7:65817282 TPST1 -0.33 -5.63 -0.33 4.48e-8 Aortic root size; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg03407747 chr17:6899364 ALOX12 0.48 8.17 0.45 1.29e-14 Tonsillectomy; CESC cis rs2070997 0.607 rs11244148 chr9:133677970 A/G cg11464064 chr9:133710261 ABL1 0.62 6.72 0.38 1.14e-10 Response to amphetamines; CESC cis rs4975616 0.839 rs2447853 chr5:1333077 A/G cg07493874 chr5:1342172 CLPTM1L -0.42 -7.9 -0.44 7.47e-14 Lung cancer; CESC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7580658 0.637 rs4580338 chr2:127974937 T/C cg10021288 chr2:128175891 PROC -0.37 -5.72 -0.33 2.92e-8 Protein C levels; CESC cis rs6032067 0.777 rs73907811 chr20:43801395 T/A cg10761708 chr20:43804764 PI3 0.56 6.66 0.38 1.58e-10 Blood protein levels; CESC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg20295408 chr7:1910781 MAD1L1 -0.4 -5.21 -0.3 3.89e-7 Bipolar disorder and schizophrenia; CESC cis rs2832191 0.740 rs13048618 chr21:30458684 A/G cg24692254 chr21:30365293 RNF160 1.0 17.69 0.74 8.64e-47 Dental caries; CESC cis rs897984 0.806 rs1458202 chr16:30953202 A/G cg00531865 chr16:30841666 NA -0.51 -7.14 -0.4 8.76e-12 Dementia with Lewy bodies; CESC cis rs644799 1.000 rs546809 chr11:95579938 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.94 13.87 0.65 3.02e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs738322 0.967 rs4385 chr22:38573229 T/C cg25457927 chr22:38595422 NA -0.29 -5.35 -0.31 1.89e-7 Cutaneous nevi; CESC cis rs60843830 0.508 rs300750 chr2:208794 T/G cg00108164 chr2:264199 ACP1;SH3YL1 0.47 6.01 0.35 6.07e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs6032067 0.929 rs17424696 chr20:43810734 G/A cg10761708 chr20:43804764 PI3 0.53 6.44 0.37 5.61e-10 Blood protein levels; CESC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg17971929 chr21:40555470 PSMG1 1.05 15.99 0.7 9.33e-41 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01144275 chr17:79478508 ACTG1 0.53 6.08 0.35 4.07e-9 Gut microbiome composition (summer); CESC cis rs672059 1.000 rs566625 chr1:183161441 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 8.74 0.47 2.68e-16 Hypertriglyceridemia; CESC cis rs10883723 0.810 rs12265877 chr10:104247247 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.48 0.42 1.09e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg03188948 chr7:1209495 NA 0.6 5.93 0.34 9.51e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg01570182 chr17:44337453 NA 0.63 8.66 0.47 4.84e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg21782813 chr7:2030301 MAD1L1 0.37 5.19 0.3 4.19e-7 Bipolar disorder and schizophrenia; CESC cis rs7818688 1.000 rs9297950 chr8:96025659 A/G cg16049864 chr8:95962084 TP53INP1 0.61 5.74 0.33 2.62e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs2249625 1.000 rs2496522 chr6:72909076 A/G cg18830697 chr6:72922368 RIMS1 -0.43 -6.24 -0.36 1.7e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs847577 0.722 rs7790736 chr7:97713039 G/A cg21770322 chr7:97807741 LMTK2 0.64 10.58 0.55 4.59e-22 Breast cancer; CESC cis rs8038465 0.904 rs12594627 chr15:73986264 G/T cg15420318 chr15:73925796 NPTN 0.41 5.65 0.33 4.21e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs11098499 0.754 rs10212714 chr4:120254302 T/C cg09307838 chr4:120376055 NA 0.79 10.52 0.54 7.35e-22 Corneal astigmatism; CESC cis rs2718058 0.613 rs2718037 chr7:37777846 G/C cg24998770 chr7:37888106 TXNDC3 0.36 5.42 0.32 1.34e-7 Alzheimer's disease (late onset); CESC cis rs6088590 1.000 rs6088595 chr20:33358499 T/A cg24642439 chr20:33292090 TP53INP2 0.84 11.14 0.56 6.84e-24 Coronary artery disease; CESC cis rs7552404 0.545 rs12748741 chr1:76351193 A/G cg10523679 chr1:76189770 ACADM -0.59 -5.98 -0.34 7.31e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9309473 0.519 rs13017182 chr2:73891004 G/T cg20560298 chr2:73613845 ALMS1 0.52 7.46 0.42 1.21e-12 Metabolite levels; CESC cis rs8018808 0.935 rs17824316 chr14:77930407 G/A cg20045696 chr14:77926864 AHSA1 0.43 5.9 0.34 1.13e-8 Myeloid white cell count; CESC cis rs2230307 0.536 rs554742 chr1:100512568 G/A cg24955406 chr1:100503596 HIAT1 0.53 5.08 0.3 7.04e-7 Carotid intima media thickness; CESC cis rs2072499 0.931 rs1052053 chr1:156202173 A/G cg25208724 chr1:156163844 SLC25A44 0.89 15.68 0.69 1.23e-39 Testicular germ cell tumor; CESC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg20398880 chr6:41068722 NFYA;LOC221442 0.39 5.27 0.31 2.82e-7 Alzheimer's disease (late onset); CESC cis rs1348850 0.567 rs4144276 chr2:178523420 T/C cg23306229 chr2:178417860 TTC30B 0.52 6.28 0.36 1.36e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3087591 0.959 rs2051505 chr17:29699859 C/G cg24425628 chr17:29625626 OMG;NF1 -0.46 -5.86 -0.34 1.38e-8 Hip circumference; CESC cis rs6545883 0.894 rs2694643 chr2:61604383 A/G cg15711740 chr2:61764176 XPO1 -0.4 -5.11 -0.3 6.31e-7 Tuberculosis; CESC cis rs6754311 0.731 rs687670 chr2:136740900 T/C cg07169764 chr2:136633963 MCM6 0.69 8.52 0.46 1.22e-15 Mosquito bite size; CESC cis rs1153858 0.943 rs1145079 chr15:45681761 T/C cg21132104 chr15:45694354 SPATA5L1 0.77 10.24 0.53 5.77e-21 Homoarginine levels; CESC cis rs2404602 0.647 rs10152247 chr15:76942252 T/G cg23625390 chr15:77176239 SCAPER -0.45 -6.27 -0.36 1.47e-9 Blood metabolite levels; CESC cis rs2019216 0.521 rs2175657 chr17:21908494 T/G cg22648282 chr17:21454238 C17orf51 -0.45 -5.89 -0.34 1.19e-8 Pelvic organ prolapse; CESC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg22920501 chr2:26401640 FAM59B -0.79 -9.3 -0.5 5.61e-18 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22281935 chr2:162934111 NA -0.43 -6.33 -0.36 1.05e-9 Gut microbiota (bacterial taxa); CESC trans rs561341 1.000 rs4795667 chr17:30244443 T/C cg27661571 chr11:113659931 NA -0.71 -7.13 -0.4 9.68e-12 Hip circumference adjusted for BMI; CESC cis rs7078219 0.965 rs7081858 chr10:101274565 G/A cg09788492 chr10:101292477 NKX2-3 0.29 5.29 0.31 2.62e-7 Dental caries; CESC cis rs5753618 0.561 rs2078803 chr22:31652852 G/A cg02404636 chr22:31891804 SFI1 -0.39 -5.09 -0.3 6.68e-7 Colorectal cancer; CESC cis rs10774547 1.000 rs4766962 chr12:120863235 A/T cg12219531 chr12:120966889 COQ5 0.43 5.46 0.32 1.09e-7 Reading disability or specific language impairment (pleiotropy);Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy); CESC cis rs694739 0.628 rs11606081 chr11:64137875 T/C cg02228329 chr11:64053129 BAD;GPR137 0.62 7.67 0.43 3.25e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg21782813 chr7:2030301 MAD1L1 0.49 6.94 0.39 2.98e-11 Bipolar disorder and schizophrenia; CESC trans rs801193 1.000 rs7788576 chr7:66148302 G/A cg26939375 chr7:64535504 NA -0.64 -8.61 -0.47 6.84e-16 Aortic root size; CESC cis rs2380220 0.541 rs72928283 chr6:96082490 A/C cg04719120 chr6:96025338 MANEA -0.64 -6.82 -0.39 6.23e-11 Behavioural disinhibition (generation interaction); CESC cis rs11252926 0.545 rs1551508 chr10:555469 A/G cg03684893 chr10:554711 DIP2C -0.44 -6.88 -0.39 4.2e-11 Psychosis in Alzheimer's disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09366861 chr1:211556286 C1orf97 0.49 6.33 0.36 1.04e-9 Systemic lupus erythematosus; CESC cis rs3820068 0.608 rs12091750 chr1:16042766 T/C cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.35 4.28e-9 Systolic blood pressure; CESC cis rs113835537 0.529 rs2298806 chr11:66282095 G/A cg24851651 chr11:66362959 CCS 0.45 5.55 0.32 6.92e-8 Airway imaging phenotypes; CESC cis rs8072100 0.840 rs9895746 chr17:45479099 C/A cg08085267 chr17:45401833 C17orf57 -0.53 -7.1 -0.4 1.14e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs950169 0.881 rs150965 chr15:85080527 T/G cg17507749 chr15:85114479 UBE2QP1 0.58 6.56 0.37 2.82e-10 Schizophrenia; CESC cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg16339924 chr4:17578868 LAP3 0.64 8.12 0.45 1.79e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4604732 0.631 rs11490198 chr1:247625703 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11867934 0.531 rs3803761 chr17:17116412 A/G cg20098446 chr17:17120238 FLCN 0.38 5.99 0.35 6.78e-9 Diabetic retinopathy; CESC cis rs6912958 0.728 rs7773906 chr6:88251869 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.55 -0.37 3.03e-10 Monocyte percentage of white cells; CESC cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg23462726 chr11:62437636 C11orf83;C11orf48 -0.39 -5.06 -0.3 7.68e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 10.92 0.56 3.59e-23 Platelet count; CESC cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg11366901 chr6:160182831 ACAT2 0.76 9.68 0.51 3.64e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs7937682 0.855 rs11213985 chr11:111581521 C/A cg22437258 chr11:111473054 SIK2 0.68 8.94 0.48 6.91e-17 Primary sclerosing cholangitis; CESC cis rs1801251 0.752 rs709938 chr2:233746457 C/T cg25237894 chr2:233734115 C2orf82 -0.49 -8.71 -0.47 3.36e-16 Coronary artery disease; CESC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -12.15 -0.6 2.74e-27 Alzheimer's disease; CESC cis rs854765 0.547 rs2955370 chr17:17966945 C/T cg09796270 chr17:17721594 SREBF1 -0.38 -5.16 -0.3 4.93e-7 Total body bone mineral density; CESC cis rs11078597 0.671 rs62090058 chr17:1645624 G/C cg18436246 chr17:1640651 WDR81 0.62 7.59 0.42 5.36e-13 Serum albumin level; CESC cis rs9302635 0.513 rs9923575 chr16:72230112 C/T cg01557791 chr16:72042693 DHODH -0.63 -6.64 -0.38 1.76e-10 Blood protein levels; CESC cis rs2228479 0.850 rs12597299 chr16:89822364 C/A cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC trans rs60843830 1.000 rs79716074 chr2:277003 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 8.6 0.47 7.3e-16 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9399135 0.933 rs28384512 chr6:135376232 C/T cg22676075 chr6:135203613 NA 0.5 7.07 0.4 1.34e-11 Red blood cell count; CESC cis rs8067354 0.958 rs2777889 chr17:57848006 A/G cg02344993 chr17:57696989 CLTC 0.48 6.21 0.36 2.06e-9 Hemoglobin concentration; CESC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg19766460 chr21:43528205 UMODL1;C21orf128 0.95 13.13 0.63 1.17e-30 IgG glycosylation; CESC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg05564831 chr3:52568323 NT5DC2 0.46 7.33 0.41 2.88e-12 Bipolar disorder; CESC cis rs35995292 0.534 rs2392607 chr7:38930380 G/A cg19327137 chr7:38886074 VPS41 0.66 10.9 0.56 4.24e-23 Subjective well-being (multi-trait analysis); CESC cis rs7212590 0.581 rs57812342 chr17:57827154 A/G cg20303301 chr17:57937339 TUBD1 -0.56 -5.06 -0.3 7.79e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs7267979 1.000 rs2258769 chr20:25276680 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC trans rs3942852 0.688 rs10742834 chr11:48169717 G/A cg15704280 chr7:45808275 SEPT13 -0.72 -8.13 -0.45 1.69e-14 Acute lymphoblastic leukemia (childhood); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11472173 chr17:41624099 ETV4 -0.43 -6.08 -0.35 4.2e-9 Gambling; CESC cis rs909002 0.749 rs10914462 chr1:32125943 A/G cg13919466 chr1:32135498 COL16A1 0.41 7.14 0.4 9.18e-12 Intelligence (multi-trait analysis); CESC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg11663144 chr21:46675770 NA -0.64 -10.05 -0.53 2.34e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3772130 0.527 rs2141614 chr3:121590173 G/A cg20356878 chr3:121714668 ILDR1 0.43 6.31 0.36 1.19e-9 Cognitive performance; CESC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg22433210 chr17:43662623 NA 0.58 7.2 0.4 6.19e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6991838 0.557 rs7012578 chr8:66504827 A/C cg13398993 chr8:66546079 ARMC1 -0.47 -5.59 -0.32 5.56e-8 Intelligence (multi-trait analysis); CESC cis rs7727544 0.606 rs2631360 chr5:131707429 A/G cg24060327 chr5:131705240 SLC22A5 -0.41 -5.04 -0.3 8.72e-7 Blood metabolite levels; CESC cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.583 rs4925130 chr17:17807858 G/A cg09796270 chr17:17721594 SREBF1 0.46 6.44 0.37 5.57e-10 Total body bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20662616 chr2:30454643 LBH -0.44 -6.67 -0.38 1.51e-10 Gambling; CESC cis rs250677 1.000 rs28173 chr5:148423573 C/T cg18129178 chr5:148520854 ABLIM3 -0.47 -5.52 -0.32 8.26e-8 Breast cancer; CESC cis rs9660180 0.967 rs61422524 chr1:1767565 C/A cg03396347 chr1:1875803 NA -0.43 -6.75 -0.38 9.5e-11 Body mass index; CESC cis rs6460942 0.908 rs78682952 chr7:12284886 C/A cg20607287 chr7:12443886 VWDE -0.57 -6.07 -0.35 4.48e-9 Coronary artery disease; CESC trans rs4950322 0.580 rs72706428 chr1:146581801 G/A cg04954894 chr8:38089920 DDHD2 -0.59 -6.42 -0.37 6.22e-10 Protein quantitative trait loci; CESC cis rs1568889 1.000 rs12790932 chr11:28046189 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 10.49 0.54 9.55e-22 Bipolar disorder; CESC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg21782813 chr7:2030301 MAD1L1 0.42 6.13 0.35 3.12e-9 Bipolar disorder and schizophrenia; CESC cis rs561341 1.000 rs508192 chr17:30315147 C/T cg19193384 chr17:30244184 NA 0.64 5.9 0.34 1.11e-8 Hip circumference adjusted for BMI; CESC cis rs1707322 0.963 rs34907901 chr1:46405214 T/G cg06784218 chr1:46089804 CCDC17 0.35 6.1 0.35 3.78e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2708240 0.617 rs2710107 chr7:147593314 A/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.37 -6.2 -0.36 2.17e-9 QT interval (drug interaction); CESC cis rs7592578 0.639 rs61709084 chr2:191287685 A/C cg27211696 chr2:191398769 TMEM194B -0.6 -6.15 -0.35 2.88e-9 Diastolic blood pressure; CESC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg17077180 chr1:38461687 NA -0.42 -5.84 -0.34 1.56e-8 Coronary artery disease; CESC cis rs7618501 0.966 rs9882639 chr3:49799475 A/C cg24308560 chr3:49941425 MST1R -0.52 -7.18 -0.4 7.15e-12 Intelligence (multi-trait analysis); CESC cis rs2180341 0.538 rs11556354 chr6:127664661 G/A cg27446573 chr6:127587934 RNF146 0.53 7.24 0.41 4.9e-12 Breast cancer; CESC cis rs7824557 0.592 rs920044 chr8:11224313 C/T cg21775007 chr8:11205619 TDH 0.48 6.96 0.39 2.62e-11 Retinal vascular caliber; CESC cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg17427002 chr7:12443146 VWDE -0.53 -5.18 -0.3 4.34e-7 Coronary artery disease; CESC cis rs6502050 0.835 rs4789670 chr17:80151805 T/C cg23985595 chr17:80112537 CCDC57 -0.4 -6.33 -0.36 1.03e-9 Life satisfaction; CESC cis rs34779708 0.643 rs4275563 chr10:35545286 G/A cg04310649 chr10:35416472 CREM -0.45 -5.21 -0.3 3.84e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs2180341 1.000 rs7453272 chr6:127633959 C/T cg24812749 chr6:127587940 RNF146 -0.99 -13.09 -0.63 1.5e-30 Breast cancer; CESC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg22535103 chr8:58192502 C8orf71 0.94 10.25 0.53 5.56e-21 Developmental language disorder (linguistic errors); CESC cis rs763121 0.853 rs6001214 chr22:39149155 C/T cg14440974 chr22:39074834 NA -0.37 -5.09 -0.3 6.78e-7 Menopause (age at onset); CESC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 5.35 0.31 1.9e-7 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04839274 chr20:30160903 NA 0.58 6.58 0.37 2.56e-10 Gut microbiome composition (summer); CESC cis rs2361718 0.500 rs12451697 chr17:78100690 T/A cg23534315 chr17:78082725 GAA 0.36 5.16 0.3 4.77e-7 Yeast infection; CESC cis rs6066835 0.702 rs6095228 chr20:47279876 A/G cg18078177 chr20:47281410 PREX1 -0.69 -5.58 -0.32 5.9e-8 Multiple myeloma; CESC cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 6.02 0.35 5.82e-9 Colorectal cancer; CESC cis rs7714584 1.000 rs1896708 chr5:150245076 A/T cg22134413 chr5:150180641 NA 0.5 5.53 0.32 7.61e-8 Crohn's disease; CESC cis rs7949030 0.596 rs11231137 chr11:62315699 G/A cg11742103 chr11:62369870 EML3;MTA2 0.54 7.59 0.42 5.35e-13 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9790314 0.934 rs462413 chr3:161101587 T/C cg03342759 chr3:160939853 NMD3 -0.47 -6.07 -0.35 4.45e-9 Morning vs. evening chronotype; CESC cis rs7662987 0.517 rs2851286 chr4:100014976 A/G cg12011299 chr4:100065546 ADH4 -0.67 -7.18 -0.4 7.19e-12 Smoking initiation; CESC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -8.19 -0.45 1.11e-14 Developmental language disorder (linguistic errors); CESC cis rs826838 1.000 rs11609286 chr12:38875511 A/G cg13010199 chr12:38710504 ALG10B -0.6 -8.38 -0.46 3.22e-15 Heart rate; CESC cis rs9487051 0.768 rs445796 chr6:109520145 T/C cg01475377 chr6:109611718 NA -0.45 -6.86 -0.39 4.74e-11 Reticulocyte fraction of red cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25722142 chr6:139695762 CITED2 0.53 6.95 0.39 2.86e-11 Gut microbiota (bacterial taxa); CESC cis rs2228479 0.681 rs10153196 chr16:89967397 A/C cg00800038 chr16:89945340 TCF25 -0.59 -6.29 -0.36 1.33e-9 Skin colour saturation; CESC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs1707322 1.000 rs6429580 chr1:46275648 A/G cg05343316 chr1:45956843 TESK2 0.42 5.2 0.3 3.95e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs13064411 0.696 rs6768648 chr3:113234141 C/G cg18753928 chr3:113234510 CCDC52 -0.51 -6.17 -0.35 2.52e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs12950390 0.893 rs4239166 chr17:45847329 A/G cg00777063 chr17:45855553 NA -0.41 -6.14 -0.35 3.03e-9 IgG glycosylation; CESC cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC cis rs116095464 1.000 rs56235400 chr5:312625 G/A cg22857025 chr5:266934 NA -1.19 -10.37 -0.54 2.3e-21 Breast cancer; CESC cis rs17376456 0.569 rs2924374 chr5:93151141 T/C cg21475434 chr5:93447410 FAM172A -0.51 -5.18 -0.3 4.41e-7 Diabetic retinopathy; CESC cis rs2295499 0.782 rs111559317 chr4:2719058 A/G cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.1 -0.3 6.51e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg05340658 chr4:99064831 C4orf37 0.84 13.04 0.63 2.35e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9868809 0.772 rs12107418 chr3:48689787 A/G cg06212747 chr3:49208901 KLHDC8B -0.64 -5.53 -0.32 7.69e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs9814567 1.000 rs62271514 chr3:134298554 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.44 6.0 0.35 6.44e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7546094 1.000 rs10745330 chr1:113083439 C/T cg22162597 chr1:113214053 CAPZA1 0.36 5.44 0.32 1.24e-7 Platelet distribution width; CESC cis rs6587515 0.901 rs11204700 chr1:150660702 C/T cg13175981 chr1:150552382 MCL1 0.62 5.65 0.33 4.23e-8 Pericardial adipose tissue adjusted for height and weight; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08424427 chr5:180670815 SNORD95;GNB2L1 -0.44 -6.05 -0.35 4.86e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02996269 chr4:106394692 PPA2 -0.46 -6.44 -0.37 5.54e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19846264 chr17:4125408 ANKFY1 -0.65 -7.69 -0.43 2.89e-13 Gut microbiome composition (summer); CESC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg08859206 chr1:53392774 SCP2 -0.65 -8.93 -0.48 7.24e-17 Monocyte count; CESC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg18402987 chr7:1209562 NA 0.78 8.65 0.47 4.88e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg09658497 chr7:2847517 GNA12 -0.43 -6.11 -0.35 3.49e-9 Height; CESC cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3008870 0.959 rs56707923 chr1:67388016 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.06 14.98 0.68 3.54e-37 Lymphocyte percentage of white cells; CESC cis rs7267979 0.834 rs6115100 chr20:25225938 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.6 0.69 2.21e-39 Liver enzyme levels (alkaline phosphatase); CESC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs2016266 0.787 rs4520636 chr12:53752133 G/T cg26875137 chr12:53738046 NA 0.36 5.14 0.3 5.34e-7 Bone mineral density (spine);Bone mineral density; CESC cis rs2569991 0.636 rs361225 chr3:12920171 G/T cg22481960 chr3:13008800 IQSEC1 -0.52 -6.07 -0.35 4.51e-9 Periodontitis (DPAL); CESC cis rs9513593 0.901 rs7335579 chr13:99939769 G/C cg21788972 chr13:99853209 UBAC2 -0.56 -6.68 -0.38 1.36e-10 Psoriasis; CESC cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg20135002 chr11:47629003 NA -0.4 -5.23 -0.31 3.37e-7 Subjective well-being; CESC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.69 -7.63 -0.42 4.32e-13 Gut microbiome composition (summer); CESC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg13902645 chr11:5959945 NA -0.68 -10.46 -0.54 1.14e-21 DNA methylation (variation); CESC cis rs910316 1.000 rs7156328 chr14:75532941 T/C cg08847533 chr14:75593920 NEK9 1.0 18.9 0.76 5.02e-51 Height; CESC cis rs9910055 0.664 rs433610 chr17:42197281 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.59 -7.64 -0.42 4e-13 Total body bone mineral density; CESC cis rs9811920 0.609 rs793466 chr3:99609837 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs9291683 0.507 rs6845554 chr4:10013173 T/G cg11266682 chr4:10021025 SLC2A9 0.68 13.13 0.63 1.11e-30 Bone mineral density; CESC cis rs11673344 0.528 rs491326 chr19:37410939 G/A cg27390819 chr19:37464633 NA -0.35 -5.16 -0.3 4.77e-7 Obesity-related traits; CESC cis rs1018836 0.923 rs11784529 chr8:91640956 C/A cg16814680 chr8:91681699 NA -0.75 -10.66 -0.55 2.51e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs67478160 0.643 rs2024667 chr14:104211529 T/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.89 0.56 4.58e-23 Schizophrenia; CESC cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg01579765 chr21:45077557 HSF2BP -0.52 -9.24 -0.49 8.14e-18 Mean corpuscular volume; CESC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg17143192 chr8:8559678 CLDN23 -0.73 -9.0 -0.48 4.36e-17 Obesity-related traits; CESC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg11247378 chr22:39784982 NA -0.64 -9.59 -0.51 7.09e-19 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs2439831 0.681 rs484846 chr15:43600803 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.21 0.63 6.03e-31 Lung cancer in ever smokers; CESC cis rs854765 0.583 rs4925130 chr17:17807858 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 6.0 0.35 6.51e-9 Total body bone mineral density; CESC cis rs2839186 0.681 rs13047198 chr21:47701835 T/C cg02776659 chr21:47717406 C21orf57 -0.35 -5.2 -0.3 3.94e-7 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05721645 chr1:246729578 CNST;TFB2M 0.54 6.09 0.35 4.02e-9 Gut microbiome composition (summer); CESC cis rs2645694 0.626 rs2645684 chr4:77819892 A/C cg18351406 chr4:77819688 ANKRD56 0.54 6.79 0.38 7.56e-11 Emphysema distribution in smoking; CESC cis rs13064411 0.696 rs2129434 chr3:113138763 A/C cg18753928 chr3:113234510 CCDC52 -0.51 -6.14 -0.35 3.05e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs738322 0.967 rs133018 chr22:38572761 G/A cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC cis rs1957429 0.901 rs1467569 chr14:65347986 T/C cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg26335602 chr6:28129616 ZNF389 0.47 6.23 0.36 1.86e-9 Parkinson's disease; CESC cis rs854765 0.619 rs6502636 chr17:17983817 A/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.46 5.82 0.34 1.7e-8 Total body bone mineral density; CESC trans rs6964833 0.935 rs34762099 chr7:74050694 T/C cg07504079 chr7:72649617 NCF1B -0.55 -6.18 -0.35 2.43e-9 Menarche (age at onset); CESC cis rs6732160 0.809 rs6728959 chr2:73383327 C/T cg01422370 chr2:73384389 NA 0.44 7.59 0.42 5.4e-13 Intelligence (multi-trait analysis); CESC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg03452623 chr4:187889614 NA -0.94 -18.99 -0.76 2.42e-51 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg25036284 chr2:26402008 FAM59B -0.59 -6.88 -0.39 4.37e-11 Gut microbiome composition (summer); CESC cis rs4523957 0.855 rs11078883 chr17:2138828 C/G cg16513277 chr17:2031491 SMG6 -0.57 -7.69 -0.43 2.97e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs34779708 0.801 rs34592588 chr10:35540134 A/G cg03585969 chr10:35415529 CREM 0.57 6.54 0.37 3.19e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs1003719 0.788 rs60447195 chr21:38448600 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.64 0.47 5.56e-16 Eye color traits; CESC cis rs643506 0.817 rs658373 chr11:111682991 T/C cg17089665 chr11:111648010 NA -0.36 -5.25 -0.31 3.11e-7 Breast cancer; CESC trans rs11098499 0.731 rs10015579 chr4:120271802 T/C cg25214090 chr10:38739885 LOC399744 0.6 8.36 0.46 3.68e-15 Corneal astigmatism; CESC cis rs3126085 0.935 rs4845745 chr1:152185184 C/T cg03465714 chr1:152285911 FLG -0.43 -5.16 -0.3 4.81e-7 Atopic dermatitis; CESC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg19592336 chr6:28129416 ZNF389 0.53 6.51 0.37 3.7e-10 Parkinson's disease; CESC cis rs1559088 0.546 rs11881543 chr19:33559372 T/G cg17764715 chr19:33622953 WDR88 0.6 8.42 0.46 2.45e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7809950 0.954 rs2520245 chr7:107137428 G/C cg23024343 chr7:107201750 COG5 -0.44 -6.21 -0.36 2.03e-9 Coronary artery disease; CESC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 0.43 6.17 0.35 2.55e-9 IgG glycosylation; CESC cis rs2228479 0.850 rs17233448 chr16:89816424 G/T cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC trans rs916888 0.773 rs199439 chr17:44793503 A/G cg01341218 chr17:43662625 NA 0.92 10.98 0.56 2.25e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs34779708 0.966 rs7913615 chr10:35422957 T/G cg03585969 chr10:35415529 CREM 0.76 9.94 0.52 5.31e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs67478160 0.643 rs1535098 chr14:104216513 T/A cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.06 -0.4 1.45e-11 Schizophrenia; CESC cis rs6502050 0.835 rs8078795 chr17:80126320 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.61e-10 Life satisfaction; CESC cis rs2637266 1.000 rs1907298 chr10:78329928 A/T cg18941641 chr10:78392320 NA 0.41 7.45 0.42 1.3e-12 Pulmonary function; CESC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg06718696 chr17:78121285 EIF4A3 -0.5 -6.75 -0.38 9.39e-11 Yeast infection; CESC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg07648498 chr16:89883185 FANCA -0.43 -5.23 -0.31 3.48e-7 Vitiligo; CESC cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 7.24 0.41 4.88e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs13082711 0.911 rs13075550 chr3:27427618 A/G cg02860705 chr3:27208620 NA 0.56 6.89 0.39 4.13e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs1499614 0.803 rs1796229 chr7:66119661 G/A cg18252515 chr7:66147081 NA -1.42 -14.43 -0.66 3.04e-35 Gout; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09205801 chr11:34378956 ABTB2 0.56 6.38 0.36 7.83e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17983724 chr7:72298804 TYW1B;SBDSP 0.61 6.93 0.39 3.24e-11 Gut microbiome composition (summer); CESC cis rs4555082 0.874 rs11625098 chr14:105756891 A/G cg27165867 chr14:105738592 BRF1 -0.51 -5.21 -0.31 3.72e-7 Mean platelet volume;Platelet distribution width; CESC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg24060327 chr5:131705240 SLC22A5 -0.75 -10.36 -0.54 2.45e-21 Breast cancer; CESC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg04546413 chr19:29218101 NA 0.57 8.55 0.46 1.03e-15 Methadone dose in opioid dependence; CESC cis rs6500395 1.000 rs12599744 chr16:48716729 G/A cg04672837 chr16:48644449 N4BP1 -0.51 -6.51 -0.37 3.67e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs10129255 0.500 rs988132 chr14:107184997 C/T cg23076370 chr14:107095027 NA -0.63 -9.22 -0.49 9.9e-18 Kawasaki disease; CESC cis rs6815814 0.950 rs5743560 chr4:38806200 G/T cg02016764 chr4:38805732 TLR1 -0.63 -7.26 -0.41 4.22e-12 Breast cancer; CESC cis rs72945132 0.882 rs7123602 chr11:70181489 C/T cg14191688 chr11:70257035 CTTN 0.42 5.36 0.31 1.84e-7 Coronary artery disease; CESC cis rs853679 0.769 rs7752448 chr6:28301099 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.75 6.65 0.38 1.65e-10 Depression; CESC cis rs7561273 0.586 rs13418279 chr2:24349218 G/T cg20701182 chr2:24300061 SF3B14 0.46 6.01 0.35 6.27e-9 Quantitative traits; CESC cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg11941060 chr3:133502564 NA -0.41 -5.59 -0.32 5.66e-8 Iron status biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20986608 chr11:65733627 SART1 -0.54 -6.26 -0.36 1.52e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14806418 chr10:131904271 NA -0.56 -6.43 -0.37 5.99e-10 Gut microbiome composition (summer); CESC cis rs4766566 0.694 rs3843673 chr12:111746499 A/G cg10833066 chr12:111807467 FAM109A 0.32 5.13 0.3 5.64e-7 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; CESC cis rs2228479 1.000 rs62052186 chr16:89969567 A/T cg06558623 chr16:89946397 TCF25 1.14 8.82 0.48 1.55e-16 Skin colour saturation; CESC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg23172400 chr8:95962367 TP53INP1 -0.44 -9.04 -0.49 3.45e-17 Type 2 diabetes; CESC cis rs12586317 0.547 rs78609489 chr14:35497285 T/C cg16230307 chr14:35515116 FAM177A1 1.11 11.72 0.58 7.81e-26 Psoriasis; CESC cis rs9467711 0.659 rs35555795 chr6:26509382 C/T cg14345882 chr6:26364793 BTN3A2 0.62 5.11 0.3 6.12e-7 Autism spectrum disorder or schizophrenia; CESC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg07677032 chr17:61819896 STRADA 0.41 5.22 0.31 3.57e-7 Height; CESC cis rs10791097 0.694 rs6590520 chr11:130747386 C/G cg12179176 chr11:130786555 SNX19 0.64 9.92 0.52 6.17e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7193541 0.550 rs28607667 chr16:74476015 C/T cg01733217 chr16:74700730 RFWD3 -0.68 -9.31 -0.5 5.03e-18 Multiple myeloma; CESC cis rs8141529 0.748 rs5762881 chr22:29289346 C/A cg15103426 chr22:29168792 CCDC117 0.61 7.95 0.44 5.34e-14 Lymphocyte counts; CESC cis rs9488822 0.676 rs12190737 chr6:116328128 C/A cg05304507 chr6:116381966 FRK 0.25 6.53 0.37 3.39e-10 Cholesterol, total;LDL cholesterol; CESC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.07 0.3 7.62e-7 Menopause (age at onset); CESC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg12463550 chr7:65579703 CRCP -0.47 -6.08 -0.35 4.28e-9 Aortic root size; CESC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.44 0.5 1.97e-18 Menopause (age at onset); CESC cis rs78707713 0.511 rs28697194 chr10:71215483 T/C cg12610070 chr10:71211762 TSPAN15 -0.3 -6.37 -0.36 8.41e-10 Venous thromboembolism; CESC cis rs3749237 0.595 rs11130199 chr3:49538799 T/C cg03060546 chr3:49711283 APEH 0.78 11.82 0.59 3.47e-26 Resting heart rate; CESC cis rs9325144 0.505 rs901635 chr12:38646572 A/C cg26384229 chr12:38710491 ALG10B -0.66 -10.66 -0.55 2.65e-22 Morning vs. evening chronotype; CESC cis rs6430585 0.646 rs1057031 chr2:136633962 G/A cg07169764 chr2:136633963 MCM6 1.32 20.96 0.79 3.38e-58 Corneal structure; CESC cis rs1348850 0.668 rs4893972 chr2:178496874 T/C cg23306229 chr2:178417860 TTC30B 0.55 6.63 0.38 1.89e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg04282206 chr17:62833786 PLEKHM1P 0.55 6.5 0.37 4.06e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg02951883 chr7:2050386 MAD1L1 0.49 6.26 0.36 1.52e-9 Bipolar disorder and schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01399255 chr7:100271274 GNB2 -0.47 -6.1 -0.35 3.74e-9 Ulcerative colitis; CESC trans rs7824557 0.564 rs7821459 chr8:11236681 T/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.15 -0.35 2.9e-9 Retinal vascular caliber; CESC cis rs6963495 0.818 rs73190155 chr7:105153535 T/A cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs73001065 0.901 rs10401969 chr19:19407718 A/G cg03709012 chr19:19516395 GATAD2A 0.95 6.27 0.36 1.47e-9 LDL cholesterol; CESC cis rs116095464 0.558 rs9654453 chr5:299621 T/C cg22857025 chr5:266934 NA -1.31 -14.05 -0.65 7.02e-34 Breast cancer; CESC cis rs7845219 0.544 rs2123647 chr8:95931782 A/G cg09323728 chr8:95962352 TP53INP1 0.33 6.43 0.37 5.98e-10 Type 2 diabetes; CESC cis rs12950390 0.853 rs12450733 chr17:45855404 A/G cg00777063 chr17:45855553 NA -0.4 -5.9 -0.34 1.12e-8 IgG glycosylation; CESC cis rs7666738 0.716 rs35195511 chr4:98859660 G/A cg17366294 chr4:99064904 C4orf37 0.55 7.73 0.43 2.21e-13 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg08888203 chr3:10149979 C3orf24 0.46 6.05 0.35 4.97e-9 Alzheimer's disease; CESC cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3791556 0.504 rs1001285 chr2:240107814 A/G cg03281426 chr2:240109471 HDAC4 0.68 10.78 0.55 1.05e-22 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7116495 0.609 rs4945378 chr11:71668866 G/A cg26138937 chr11:71823887 C11orf51 -1.23 -8.41 -0.46 2.56e-15 Severe influenza A (H1N1) infection; CESC cis rs12887734 0.524 rs12588797 chr14:104300020 C/T cg01849466 chr14:104193079 ZFYVE21 0.46 5.8 0.34 1.84e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs6088590 1.000 rs28542147 chr20:33376323 G/A cg06115741 chr20:33292138 TP53INP2 0.6 7.39 0.41 1.96e-12 Coronary artery disease; CESC cis rs9910055 0.530 rs2269905 chr17:42294462 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.35 5.12 0.3 5.9e-7 Total body bone mineral density; CESC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg03709012 chr19:19516395 GATAD2A 1.01 15.89 0.7 2.1e-40 Tonsillectomy; CESC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg26818010 chr10:134567672 INPP5A -0.87 -10.83 -0.55 7.44e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.73 10.84 0.55 6.59e-23 Hip circumference adjusted for BMI; CESC cis rs6460942 0.597 rs7808537 chr7:12520913 G/C cg06484146 chr7:12443880 VWDE -0.71 -7.6 -0.42 5.22e-13 Coronary artery disease; CESC cis rs2011503 0.941 rs7257875 chr19:19372150 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.53 0.32 7.55e-8 Bipolar disorder; CESC cis rs12477438 0.765 rs17708262 chr2:99696313 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.61 -0.47 6.82e-16 Chronic sinus infection; CESC cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg21214613 chr1:16344536 HSPB7 -0.35 -5.17 -0.3 4.62e-7 Dilated cardiomyopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06385459 chr4:82393184 RASGEF1B 0.53 6.03 0.35 5.38e-9 Gut microbiome composition (summer); CESC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg25985355 chr7:65971099 NA -0.31 -5.03 -0.3 8.85e-7 Calcium levels; CESC cis rs62432291 0.681 rs294913 chr6:159667227 G/A cg14500486 chr6:159655392 FNDC1 -0.61 -5.93 -0.34 9.62e-9 Joint mobility (Beighton score); CESC cis rs10992471 0.598 rs2031262 chr9:95170368 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.41 -5.27 -0.31 2.84e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs3820068 0.603 rs41270279 chr1:15988878 A/G cg17385448 chr1:15911702 AGMAT 0.44 7.31 0.41 3.13e-12 Systolic blood pressure; CESC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg07677032 chr17:61819896 STRADA 0.47 6.28 0.36 1.35e-9 Prudent dietary pattern; CESC cis rs15676 0.947 rs2805103 chr9:131598897 T/A cg00228799 chr9:131580591 ENDOG 0.45 5.56 0.32 6.67e-8 Blood metabolite levels; CESC cis rs7726839 0.561 rs3915384 chr5:573395 G/T cg09021430 chr5:549028 NA -0.41 -5.31 -0.31 2.37e-7 Obesity-related traits; CESC trans rs1814175 0.645 rs1851849 chr11:50012164 G/A cg03929089 chr4:120376271 NA -0.91 -14.65 -0.67 5.08e-36 Height; CESC cis rs9937943 0.667 rs35253850 chr16:74599103 T/C cg01733217 chr16:74700730 RFWD3 0.62 5.6 0.33 5.33e-8 Neutrophil percentage of white cells; CESC cis rs9815354 0.812 rs12108049 chr3:41958161 A/G cg03022575 chr3:42003672 ULK4 0.67 6.1 0.35 3.77e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg06456125 chr7:65229604 NA -0.4 -5.24 -0.31 3.33e-7 Aortic root size; CESC cis rs208520 0.608 rs3846803 chr6:66805743 C/A cg07460842 chr6:66804631 NA -1.0 -13.38 -0.63 1.55e-31 Exhaled nitric oxide output; CESC cis rs7937682 0.883 rs631490 chr11:111452040 G/C cg22437258 chr11:111473054 SIK2 0.68 9.04 0.49 3.43e-17 Primary sclerosing cholangitis; CESC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg20243544 chr17:37824526 PNMT -0.45 -5.54 -0.32 7.43e-8 Glomerular filtration rate (creatinine); CESC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.71 -7.89 -0.44 8.2e-14 Gut microbiome composition (summer); CESC cis rs1707322 0.686 rs2275085 chr1:46085852 C/T cg05343316 chr1:45956843 TESK2 -0.53 -6.46 -0.37 4.92e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg00769240 chr8:12517080 NA -0.44 -6.02 -0.35 5.7e-9 Blood pressure (smoking interaction); CESC cis rs10504073 0.584 rs1511368 chr8:49949523 A/T cg00325661 chr8:49890786 NA 0.56 8.53 0.46 1.16e-15 Blood metabolite ratios; CESC cis rs9916302 0.800 rs9892675 chr17:37549200 C/T cg20243544 chr17:37824526 PNMT -0.48 -5.13 -0.3 5.59e-7 Glomerular filtration rate (creatinine); CESC trans rs1814175 0.618 rs1851843 chr11:50021846 T/C cg15704280 chr7:45808275 SEPT13 -1.0 -18.54 -0.75 9.01e-50 Height; CESC cis rs644799 1.000 rs2508289 chr11:95624669 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.47 5.53 0.32 7.48e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9814567 1.000 rs4367113 chr3:134287975 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.1 -0.35 3.7e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs3771570 1.000 rs57196672 chr2:242235193 G/A cg21155796 chr2:242212141 HDLBP 0.61 5.16 0.3 4.88e-7 Prostate cancer; CESC cis rs6952809 0.504 rs1978169 chr7:2434522 G/A cg23289794 chr7:2394357 EIF3B -0.66 -6.69 -0.38 1.34e-10 Multiple sclerosis; CESC cis rs453301 0.538 rs7830804 chr8:8970762 G/T cg15556689 chr8:8085844 FLJ10661 -0.51 -6.48 -0.37 4.46e-10 Joint mobility (Beighton score); CESC cis rs1707322 0.717 rs2253862 chr1:46081960 C/T cg06784218 chr1:46089804 CCDC17 -0.41 -7.08 -0.4 1.31e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs965469 1.000 rs6051745 chr20:3307243 T/G cg25506879 chr20:3388711 C20orf194 -0.57 -6.15 -0.35 2.79e-9 IFN-related cytopenia; CESC cis rs6460942 0.591 rs62451465 chr7:12364585 A/G cg06484146 chr7:12443880 VWDE -0.62 -6.79 -0.39 7.18e-11 Coronary artery disease; CESC cis rs919433 0.926 rs787996 chr2:198216805 A/G cg20885578 chr2:198174922 NA 0.4 5.42 0.32 1.31e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs6121246 0.909 rs7354225 chr20:30296881 C/T cg13852791 chr20:30311386 BCL2L1 0.79 7.29 0.41 3.64e-12 Mean corpuscular hemoglobin; CESC cis rs9326248 0.530 rs10790172 chr11:116927740 G/T cg01368799 chr11:117014884 PAFAH1B2 0.57 5.23 0.31 3.49e-7 Blood protein levels; CESC cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg20503657 chr10:835505 NA 0.77 7.67 0.43 3.3e-13 Eosinophil percentage of granulocytes; CESC cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg10556349 chr10:835070 NA 0.74 6.43 0.37 5.78e-10 Eosinophil percentage of granulocytes; CESC cis rs2204008 0.774 rs11520237 chr12:38266978 G/A cg13010199 chr12:38710504 ALG10B 0.48 6.04 0.35 5.23e-9 Bladder cancer; CESC cis rs11583043 0.918 rs58029001 chr1:101393409 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 5.2 0.3 3.98e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs2109514 0.902 rs6980387 chr7:116126882 A/G cg12739419 chr7:116140593 CAV2 -0.38 -6.74 -0.38 9.73e-11 Prevalent atrial fibrillation; CESC cis rs7264396 0.690 rs2425165 chr20:34438059 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.51 -0.58 3.81e-25 Total cholesterol levels; CESC cis rs7267979 0.966 rs4813557 chr20:25292545 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -16.88 -0.72 6.68e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg23758822 chr17:41437982 NA 0.99 16.8 0.72 1.23e-43 Menopause (age at onset); CESC cis rs40363 0.720 rs4453493 chr16:3533881 T/C cg05754148 chr16:3507555 NAT15 -0.48 -6.4 -0.37 6.86e-10 Tuberculosis; CESC cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg16386425 chr10:429943 DIP2C -0.56 -7.23 -0.41 5.26e-12 Psychosis in Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14337668 chr9:99883682 NA 0.46 6.4 0.37 7.01e-10 Fibrinogen levels; CESC cis rs9549260 0.569 rs7328453 chr13:41334327 G/A cg21288729 chr13:41239152 FOXO1 0.63 5.24 0.31 3.36e-7 Red blood cell count; CESC cis rs7843479 0.509 rs899428 chr8:21770763 T/C cg17168535 chr8:21777572 XPO7 0.65 9.76 0.51 1.95e-19 Mean corpuscular volume; CESC cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg05535760 chr7:792225 HEATR2 0.86 10.52 0.54 7.3e-22 Cerebrospinal P-tau181p levels; CESC cis rs11098499 0.754 rs28652763 chr4:120242312 C/T cg09307838 chr4:120376055 NA 0.79 10.62 0.55 3.51e-22 Corneal astigmatism; CESC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg23978390 chr7:1156363 C7orf50 0.57 8.23 0.45 8.35e-15 Longevity;Endometriosis; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg07507251 chr3:52567010 NT5DC2 0.51 10.34 0.54 2.82e-21 Hemoglobin concentration; CESC cis rs2952156 0.920 rs2517955 chr17:37843681 C/T cg07936489 chr17:37558343 FBXL20 -0.6 -7.71 -0.43 2.57e-13 Asthma; CESC cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg26597838 chr10:835615 NA 0.92 9.99 0.52 3.74e-20 Eosinophil percentage of granulocytes; CESC cis rs9457247 0.663 rs2237277 chr6:167442107 G/A cg25258033 chr6:167368657 RNASET2 0.37 5.4 0.31 1.51e-7 Crohn's disease; CESC cis rs4900538 0.855 rs72698602 chr14:102880454 T/C cg18135206 chr14:102964638 TECPR2 -0.73 -9.33 -0.5 4.35e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs2204008 0.744 rs11180504 chr12:38236313 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.52 1.51e-19 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24029926 chr7:33102655 NT5C3 -0.73 -8.97 -0.48 5.37e-17 Gut microbiome composition (summer); CESC cis rs668210 0.793 rs590531 chr11:65773939 C/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.66 -6.59 -0.38 2.36e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg04553112 chr3:125709451 NA -0.52 -5.47 -0.32 1.05e-7 Blood pressure (smoking interaction); CESC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg27266027 chr21:40555129 PSMG1 0.45 5.3 0.31 2.47e-7 Cognitive function; CESC cis rs10911232 0.507 rs10911194 chr1:182993025 C/T ch.1.3577855R chr1:183094577 LAMC1 0.85 13.21 0.63 5.94e-31 Hypertriglyceridemia; CESC cis rs712039 0.652 rs829160 chr17:35763091 T/A cg16670864 chr17:35848621 DUSP14 0.48 6.12 0.35 3.37e-9 Tuberculosis; CESC cis rs11122272 0.735 rs10489611 chr1:231517854 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs12142240 0.698 rs6697123 chr1:46811310 A/C cg10495392 chr1:46806563 NSUN4 0.57 6.29 0.36 1.33e-9 Menopause (age at onset); CESC cis rs9911578 0.900 rs7214335 chr17:57158840 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.13 0.3 5.63e-7 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16408394 chr9:137219075 RXRA -0.46 -6.77 -0.38 8.4e-11 Gambling; CESC cis rs116095464 0.558 rs7730700 chr5:264713 G/A cg22857025 chr5:266934 NA -1.3 -18.55 -0.75 8.05e-50 Breast cancer; CESC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg24675658 chr1:53192096 ZYG11B -0.67 -9.54 -0.51 9.7e-19 Monocyte count; CESC cis rs9896933 0.778 rs80243549 chr17:80821485 G/T cg15664640 chr17:80829946 TBCD -0.52 -5.51 -0.32 8.68e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg13902645 chr11:5959945 NA -0.61 -7.19 -0.4 6.77e-12 DNA methylation (variation); CESC cis rs2180341 0.782 rs6912006 chr6:127722631 C/T cg24812749 chr6:127587940 RNF146 0.74 9.83 0.52 1.18e-19 Breast cancer; CESC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg12463550 chr7:65579703 CRCP -0.5 -6.32 -0.36 1.08e-9 Aortic root size; CESC cis rs2576037 0.796 rs6507718 chr18:44581284 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.61 -8.73 -0.47 2.97e-16 Personality dimensions; CESC trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21659725 chr3:3221576 CRBN -0.83 -13.84 -0.65 3.61e-33 Intelligence (multi-trait analysis); CESC cis rs7918232 0.882 rs2149413 chr10:27430311 C/T cg14442939 chr10:27389572 ANKRD26 -0.68 -6.52 -0.37 3.61e-10 Breast cancer; CESC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg18876405 chr7:65276391 NA -0.51 -7.03 -0.4 1.7e-11 Aortic root size; CESC cis rs35146811 0.660 rs6465760 chr7:99591418 A/G cg14163444 chr7:99595348 NA 0.39 5.2 0.3 4.07e-7 Coronary artery disease; CESC cis rs1816752 0.935 rs3816219 chr13:25017133 C/T cg02811702 chr13:24901961 NA 0.39 5.66 0.33 3.86e-8 Obesity-related traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07155664 chr5:149829590 RPS14 -0.45 -6.32 -0.36 1.09e-9 Gut microbiota (bacterial taxa); CESC cis rs644799 0.965 rs565771 chr11:95644179 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.47 5.84 0.34 1.52e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs17401966 1.000 rs12734068 chr1:10376803 G/A cg15208524 chr1:10270712 KIF1B 0.45 5.64 0.33 4.31e-8 Hepatocellular carcinoma; CESC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs3820068 0.581 rs72645895 chr1:15931709 G/A cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs7666738 0.753 rs13137152 chr4:98938044 A/T cg03467027 chr4:99064603 C4orf37 0.48 5.92 0.34 9.78e-9 Colonoscopy-negative controls vs population controls; CESC cis rs12477438 0.520 rs11123761 chr2:99705903 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.39 0.69 1.29e-38 Chronic sinus infection; CESC trans rs2391518 0.639 rs2968997 chr4:130784669 A/C cg04981619 chr2:43328122 NA 0.38 6.11 0.35 3.61e-9 Body mass index; CESC cis rs34779708 0.931 rs4934721 chr10:35377715 A/G cg04310649 chr10:35416472 CREM -0.5 -5.88 -0.34 1.25e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg16325326 chr1:53192061 ZYG11B 0.72 10.81 0.55 8.67e-23 Monocyte count; CESC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg01988459 chr11:68622903 NA -0.41 -5.53 -0.32 7.51e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg19346786 chr7:2764209 NA -0.36 -5.17 -0.3 4.71e-7 Height; CESC cis rs2882667 0.964 rs12719517 chr5:138305502 C/T cg04439458 chr5:138467593 SIL1 -0.37 -5.72 -0.33 2.87e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9300255 0.739 rs1980252 chr12:123745178 C/G cg00376283 chr12:123451042 ABCB9 0.72 9.09 0.49 2.4e-17 Neutrophil percentage of white cells; CESC cis rs8078723 0.714 rs12940405 chr17:38143768 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.05 0.3 8.15e-7 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs7223966 1.000 rs9903897 chr17:61716705 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.44 0.42 1.37e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs861020 0.710 rs7516902 chr1:210022179 A/G cg05527609 chr1:210001259 C1orf107 1.09 14.97 0.68 3.91e-37 Orofacial clefts; CESC cis rs13191362 0.935 rs35100164 chr6:162963003 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 7.3 0.41 3.39e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg22823121 chr1:150693482 HORMAD1 0.43 5.86 0.34 1.4e-8 Melanoma; CESC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg22903471 chr2:27725779 GCKR -0.5 -7.08 -0.4 1.27e-11 Total body bone mineral density; CESC cis rs35110281 0.659 rs11909064 chr21:45092095 G/C cg01579765 chr21:45077557 HSF2BP -0.54 -8.98 -0.48 5.14e-17 Mean corpuscular volume; CESC cis rs55882075 0.730 rs10794700 chr5:179148335 C/G cg14593053 chr5:179126677 CANX 0.6 8.88 0.48 1.05e-16 Monocyte percentage of white cells; CESC cis rs7264396 0.563 rs1970577 chr20:34336737 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.73 -0.55 1.57e-22 Total cholesterol levels; CESC cis rs7512552 0.803 rs9435997 chr1:150289496 G/A cg15654264 chr1:150340011 RPRD2 -0.4 -5.18 -0.3 4.39e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC trans rs12960505 0.506 rs6508235 chr18:51053941 A/G cg27659478 chr17:73891062 TRIM65 -0.46 -6.11 -0.35 3.58e-9 Intelligence (multi-trait analysis); CESC cis rs870825 0.655 rs10013685 chr4:185617785 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.64 0.33 4.27e-8 Bipolar disorder; CESC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg21770322 chr7:97807741 LMTK2 0.54 8.17 0.45 1.31e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs962856 0.575 rs7597266 chr2:67621641 G/A cg09028215 chr2:67624308 ETAA1 -0.46 -5.69 -0.33 3.42e-8 Pancreatic cancer; CESC cis rs644799 1.000 rs611020 chr11:95567905 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.94 13.74 0.64 8.5e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs8067354 0.645 rs9899611 chr17:57832190 A/G cg02344993 chr17:57696989 CLTC 0.68 8.06 0.44 2.59e-14 Hemoglobin concentration; CESC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg05255149 chr17:80675120 FN3KRP -0.46 -5.27 -0.31 2.76e-7 Breast cancer; CESC cis rs644799 0.603 rs1255180 chr11:95472134 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.45 6.12 0.35 3.39e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs28374715 0.681 rs28712264 chr15:41588797 T/C cg02330683 chr15:41787940 ITPKA 0.46 5.48 0.32 9.83e-8 Ulcerative colitis; CESC cis rs9325144 0.581 rs6582564 chr12:38671282 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.1 -0.35 3.79e-9 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg27535305 chr1:53392650 SCP2 -0.33 -5.38 -0.31 1.62e-7 Monocyte count; CESC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.34 -0.36 9.76e-10 Electroencephalogram traits; CESC cis rs892961 0.931 rs2411110 chr17:75400143 A/C cg05865280 chr17:75406074 SEPT9 0.48 6.51 0.37 3.67e-10 Airflow obstruction; CESC cis rs1348850 0.645 rs4893963 chr2:178430747 A/G cg22681709 chr2:178499509 PDE11A 0.5 6.41 0.37 6.64e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4604732 0.631 rs10754561 chr1:247622800 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.46 6.44 0.37 5.74e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs847577 0.630 rs6967926 chr7:97715088 C/T cg24562669 chr7:97807699 LMTK2 0.8 13.78 0.65 5.96e-33 Breast cancer; CESC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg04944784 chr2:26401820 FAM59B -0.67 -7.61 -0.42 4.8e-13 Gut microbiome composition (summer); CESC cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg22834771 chr12:69754056 YEATS4 0.38 5.15 0.3 5.15e-7 Blood protein levels; CESC cis rs8060686 0.641 rs111632263 chr16:68233122 T/A cg26727032 chr16:67993705 SLC12A4 -0.51 -5.5 -0.32 8.83e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg24562669 chr7:97807699 LMTK2 0.51 7.54 0.42 7.72e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs881375 0.715 rs10818482 chr9:123648085 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.48 -6.84 -0.39 5.44e-11 Rheumatoid arthritis; CESC cis rs8077889 0.672 rs3785810 chr17:41850689 C/G cg26893861 chr17:41843967 DUSP3 1.01 18.7 0.75 2.58e-50 Triglycerides; CESC cis rs12893668 0.616 rs58033365 chr14:104030901 T/C cg24130564 chr14:104152367 KLC1 -0.48 -5.87 -0.34 1.31e-8 Reticulocyte count; CESC cis rs1511802 0.501 rs7684025 chr4:187116227 C/T cg24794857 chr4:187113578 CYP4V2 0.42 5.38 0.31 1.65e-7 Blood protein levels; CESC cis rs5769765 0.955 rs4075330 chr22:50303249 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.5 -5.45 -0.32 1.15e-7 Schizophrenia; CESC cis rs2011503 0.825 rs4808932 chr19:19358819 C/T cg11584989 chr19:19387371 SF4 0.54 6.58 0.37 2.46e-10 Bipolar disorder; CESC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg08888203 chr3:10149979 C3orf24 0.49 6.26 0.36 1.51e-9 Alzheimer's disease; CESC cis rs56235845 0.694 rs12055081 chr5:176757191 C/T cg17509989 chr5:176798049 RGS14 0.5 6.21 0.36 2.04e-9 Hemoglobin concentration;Hematocrit; CESC cis rs8067354 0.957 rs9896742 chr17:57826530 T/G cg13753209 chr17:57696993 CLTC 0.53 7.05 0.4 1.58e-11 Hemoglobin concentration; CESC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg11905131 chr22:24372483 LOC391322 -0.75 -10.92 -0.56 3.66e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9768139 0.935 rs7782393 chr7:158120486 G/A cg25566285 chr7:158114605 PTPRN2 -0.51 -8.75 -0.47 2.59e-16 Calcium levels; CESC trans rs459571 0.792 rs55923934 chr9:136888233 C/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.6 -7.76 -0.43 1.8e-13 Platelet distribution width; CESC cis rs3011225 0.691 rs3791102 chr1:44366617 C/T cg13606994 chr1:44402422 ARTN -0.36 -5.61 -0.33 5.17e-8 Amyotrophic lateral sclerosis (age of onset); CESC cis rs12458462 0.509 rs3786241 chr18:77494328 A/C cg11879182 chr18:77439856 CTDP1 0.57 7.88 0.44 8.33e-14 Monocyte count; CESC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.52 0.32 7.94e-8 Bipolar disorder; CESC cis rs722599 0.683 rs11848876 chr14:75224626 C/G cg11812906 chr14:75593930 NEK9 0.46 5.58 0.32 5.88e-8 IgG glycosylation; CESC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg17376030 chr22:41985996 PMM1 0.68 7.43 0.42 1.46e-12 Vitiligo; CESC trans rs804280 0.509 rs4841639 chr8:11796093 A/T cg15556689 chr8:8085844 FLJ10661 0.51 6.32 0.36 1.1e-9 Myopia (pathological); CESC cis rs936229 1.000 rs4886615 chr15:75131661 A/G cg14664628 chr15:75095509 CSK -0.86 -11.67 -0.58 1.12e-25 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 0.935 rs3114890 chr16:89449546 C/G cg08822215 chr16:89438651 ANKRD11 -0.44 -6.68 -0.38 1.4e-10 Multiple myeloma (IgH translocation); CESC cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.96 9.4 0.5 2.62e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1062746 0.834 rs9308347 chr16:87371752 C/T cg02258303 chr16:87377426 FBXO31 -0.51 -6.51 -0.37 3.8e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CESC cis rs7584330 0.868 rs13386290 chr2:238393136 G/C cg11271282 chr2:238384023 NA 0.51 5.76 0.33 2.28e-8 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09580147 chr16:22431764 RRN3P3 0.4 6.19 0.36 2.33e-9 Fibrinogen levels; CESC trans rs9393777 0.841 rs13191474 chr6:27413345 C/T cg21479132 chr6:26055353 NA 0.84 6.15 0.35 2.82e-9 Intelligence (multi-trait analysis); CESC cis rs9611565 0.694 rs202618 chr22:41822856 A/G cg17376030 chr22:41985996 PMM1 -0.76 -8.01 -0.44 3.71e-14 Vitiligo; CESC cis rs561341 1.000 rs550264 chr17:30317540 G/T cg23018236 chr17:30244563 NA -0.53 -5.21 -0.3 3.76e-7 Hip circumference adjusted for BMI; CESC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg12373951 chr3:133503437 NA 0.43 6.16 0.35 2.67e-9 Iron status biomarkers; CESC cis rs11690935 0.959 rs7355594 chr2:172639448 G/T cg13550731 chr2:172543902 DYNC1I2 -1.01 -16.63 -0.71 5.07e-43 Schizophrenia; CESC cis rs34779708 0.966 rs2505639 chr10:35474421 A/G cg03585969 chr10:35415529 CREM -0.71 -9.41 -0.5 2.52e-18 Inflammatory bowel disease;Crohn's disease; CESC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg18876405 chr7:65276391 NA -0.47 -6.39 -0.37 7.56e-10 Aortic root size; CESC cis rs3793683 0.520 rs12769959 chr10:134579026 A/C cg18305652 chr10:134549665 INPP5A 0.5 7.32 0.41 2.93e-12 Migraine; CESC cis rs8114671 0.967 rs6060285 chr20:33770487 G/T cg24642439 chr20:33292090 TP53INP2 0.44 5.37 0.31 1.73e-7 Height; CESC cis rs3857536 0.813 rs1029401 chr6:66952268 A/G cg07460842 chr6:66804631 NA -0.42 -5.11 -0.3 6.32e-7 Blood trace element (Cu levels); CESC cis rs2228479 0.850 rs11639906 chr16:89798183 T/C cg14709524 chr16:89940631 TCF25 0.78 5.43 0.32 1.3e-7 Skin colour saturation; CESC cis rs9303401 1.000 rs7218362 chr17:56888299 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.73 9.42 0.5 2.35e-18 Cognitive test performance; CESC cis rs4588572 0.537 rs7702000 chr5:77730556 A/G cg11547950 chr5:77652471 NA -0.38 -5.25 -0.31 3.12e-7 Triglycerides; CESC cis rs11098499 0.615 rs28850368 chr4:120554313 G/A cg24375607 chr4:120327624 NA 0.41 5.18 0.3 4.4e-7 Corneal astigmatism; CESC cis rs727505 1.000 rs10230610 chr7:124425398 A/C cg23710748 chr7:124431027 NA -0.47 -7.56 -0.42 6.58e-13 Lewy body disease; CESC cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg05283184 chr6:79620031 NA -0.42 -6.67 -0.38 1.47e-10 Intelligence (multi-trait analysis); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05159949 chr15:81282184 MESDC2 -0.48 -6.15 -0.35 2.78e-9 Ulcerative colitis; CESC cis rs8002861 0.664 rs895266 chr13:44461179 T/C cg19180546 chr13:44453867 C13orf31;CCDC122 0.4 5.14 0.3 5.42e-7 Leprosy; CESC trans rs3087243 0.755 rs231738 chr2:204693137 C/G cg01841312 chr10:38069945 NA 0.38 6.37 0.36 8.32e-10 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs2228479 0.557 rs62054639 chr16:89821489 C/T cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs2046867 0.818 rs62249862 chr3:72867949 G/C cg25664220 chr3:72788482 NA -0.45 -6.56 -0.37 2.88e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs9926296 0.632 rs72807526 chr16:89775946 A/G cg27121462 chr16:89883253 FANCA -0.57 -7.16 -0.4 7.91e-12 Vitiligo; CESC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg18876405 chr7:65276391 NA 0.51 7.07 0.4 1.35e-11 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18262260 chr14:89029717 ZC3H14 -0.4 -6.2 -0.36 2.14e-9 Gambling; CESC cis rs4629180 0.562 rs10198901 chr2:102127937 G/A cg04415270 chr2:102091202 RFX8 -0.3 -5.31 -0.31 2.34e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs11718455 0.960 rs17076254 chr3:44000361 C/T cg08738300 chr3:44038990 NA 0.44 6.06 0.35 4.66e-9 Coronary artery disease; CESC cis rs3820068 0.603 rs72645887 chr1:15929905 G/C cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg17143192 chr8:8559678 CLDN23 0.74 8.94 0.48 6.99e-17 Obesity-related traits; CESC cis rs9486719 0.948 rs11152953 chr6:96894305 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg22974920 chr21:40686053 BRWD1 -0.44 -5.48 -0.32 9.81e-8 Cognitive function; CESC cis rs3733585 0.699 rs7663097 chr4:9966791 T/C cg11266682 chr4:10021025 SLC2A9 -0.58 -10.94 -0.56 3.08e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6460942 0.915 rs2216050 chr7:12304073 T/C cg06484146 chr7:12443880 VWDE -0.4 -5.63 -0.33 4.48e-8 Coronary artery disease; CESC cis rs3126085 1.000 rs1858482 chr1:152306921 A/G cg03465714 chr1:152285911 FLG -0.42 -5.08 -0.3 7.09e-7 Atopic dermatitis; CESC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6e-10 Life satisfaction; CESC cis rs6693567 0.526 rs3818978 chr1:150266338 T/A cg09579323 chr1:150459698 TARS2 -0.5 -6.36 -0.36 8.99e-10 Migraine; CESC cis rs1707322 0.752 rs7529699 chr1:46134634 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.12 0.4 1.04e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4129585 0.665 rs10098073 chr8:143309504 A/C cg16886403 chr8:143471632 TSNARE1 0.41 5.18 0.3 4.35e-7 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC trans rs7937682 0.889 rs1789355 chr11:111499718 T/C cg18187862 chr3:45730750 SACM1L 0.51 6.5 0.37 3.97e-10 Primary sclerosing cholangitis; CESC cis rs3749237 0.964 rs11717463 chr3:49808981 C/T cg03060546 chr3:49711283 APEH 0.65 7.21 0.41 5.74e-12 Resting heart rate; CESC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg00129232 chr17:37814104 STARD3 0.54 7.03 0.4 1.75e-11 Glomerular filtration rate (creatinine); CESC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg00908189 chr16:619842 PIGQ 0.65 9.18 0.49 1.26e-17 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26608221 chr2:74692293 MOGS 0.65 7.28 0.41 3.69e-12 Gut microbiome composition (summer); CESC cis rs9300255 0.596 rs1727331 chr12:123718879 C/G cg00376283 chr12:123451042 ABCB9 -0.66 -9.18 -0.49 1.29e-17 Neutrophil percentage of white cells; CESC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.56 7.29 0.41 3.66e-12 Bipolar disorder; CESC cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg24308560 chr3:49941425 MST1R -0.52 -7.27 -0.41 4.16e-12 Body mass index; CESC cis rs1372520 0.684 rs1442148 chr4:90748846 T/A cg15133208 chr4:90757351 SNCA -0.4 -5.34 -0.31 2.01e-7 Neuroticism; CESC cis rs644799 1.000 rs566204 chr11:95580926 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 13.82 0.65 4.39e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg00745463 chr17:30367425 LRRC37B -0.88 -7.76 -0.43 1.9e-13 Hip circumference adjusted for BMI; CESC cis rs1707322 0.752 rs10789467 chr1:46118745 C/G cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12478296 0.685 rs12473450 chr2:242991746 C/T cg06360820 chr2:242988706 NA -0.71 -8.96 -0.48 5.82e-17 Obesity-related traits; CESC cis rs7727544 0.594 rs10479000 chr5:131607402 T/C cg14196790 chr5:131705035 SLC22A5 0.38 5.68 0.33 3.59e-8 Blood metabolite levels; CESC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 11.76 0.59 5.69e-26 Platelet count; CESC cis rs1707322 0.928 rs10732844 chr1:46372688 T/C cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.72 0.38 1.13e-10 Bipolar disorder; CESC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg23978390 chr7:1156363 C7orf50 0.6 8.72 0.47 3.01e-16 Longevity;Endometriosis; CESC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.88 0.34 1.23e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg17366294 chr4:99064904 C4orf37 0.57 7.92 0.44 6.72e-14 Colonoscopy-negative controls vs population controls; CESC trans rs801193 1.000 rs3800812 chr7:66223461 T/C cg26939375 chr7:64535504 NA 0.67 9.16 0.49 1.49e-17 Aortic root size; CESC cis rs8078723 1.000 rs4795412 chr17:38150604 C/T cg17467752 chr17:38218738 THRA 0.68 10.14 0.53 1.24e-20 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs2235642 0.750 rs2974845 chr16:1648162 T/C cg03715980 chr16:1756201 MAPK8IP3 0.4 5.25 0.31 3.08e-7 Coronary artery disease; CESC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg18876405 chr7:65276391 NA 0.5 6.68 0.38 1.43e-10 Aortic root size; CESC cis rs116095464 0.558 rs113796397 chr5:246503 A/G cg22496380 chr5:211416 CCDC127 -0.73 -7.94 -0.44 5.87e-14 Breast cancer; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg05935374 chr11:82782929 RAB30 0.45 6.23 0.36 1.79e-9 Weight; CESC cis rs1950626 0.705 rs34991312 chr14:101435167 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.83 11.29 0.57 2.14e-24 Pelvic organ prolapse (moderate/severe); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12934466 chr18:32820979 ZNF397 -0.45 -6.28 -0.36 1.35e-9 Fibrinogen levels; CESC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg12963246 chr6:28129442 ZNF389 -0.49 -6.88 -0.39 4.25e-11 Depression; CESC cis rs637571 0.522 rs538954 chr11:65756808 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.42 5.2 0.3 4.08e-7 Eosinophil percentage of white cells; CESC cis rs910316 1.000 rs11845639 chr14:75570293 C/T cg11812906 chr14:75593930 NEK9 0.86 14.55 0.67 1.2e-35 Height; CESC cis rs11650494 0.710 rs8066722 chr17:47475007 A/G cg08112188 chr17:47440006 ZNF652 -0.84 -6.2 -0.36 2.12e-9 Prostate cancer; CESC trans rs35110281 0.626 rs162368 chr21:44934767 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 6.06 0.35 4.67e-9 Mean corpuscular volume; CESC cis rs7590368 0.673 rs56264212 chr2:10931435 A/C cg15705551 chr2:10952987 PDIA6 0.55 5.26 0.31 2.96e-7 Educational attainment (years of education); CESC cis rs11864453 0.793 rs7197453 chr16:72079127 G/C cg23815491 chr16:72088622 HP 0.37 5.09 0.3 6.78e-7 Fibrinogen levels; CESC cis rs977987 0.806 rs8054769 chr16:75401113 T/C cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.73e-8 Dupuytren's disease; CESC cis rs2637266 0.791 rs2395392 chr10:78359933 C/A cg18941641 chr10:78392320 NA 0.41 7.64 0.42 3.93e-13 Pulmonary function; CESC cis rs829883 0.966 rs249853 chr12:98864908 A/C cg25150519 chr12:98850993 NA 0.61 7.9 0.44 7.44e-14 Colorectal adenoma (advanced); CESC cis rs5498 0.869 rs892188 chr19:10409793 A/G cg08845333 chr19:10403403 ICAM5 -0.38 -5.08 -0.3 7.07e-7 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs61542988 0.570 rs62448267 chr7:22822501 T/C cg13679077 chr7:22862647 TOMM7 0.6 6.55 0.37 2.94e-10 Fibrinogen levels; CESC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg19622623 chr12:86230825 RASSF9 -0.47 -5.96 -0.34 8.09e-9 Major depressive disorder; CESC cis rs9948 0.655 rs62156212 chr2:97399096 C/T cg01990225 chr2:97406019 LMAN2L -1.02 -7.77 -0.43 1.76e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs1957429 0.808 rs4902327 chr14:65344803 C/T cg23373153 chr14:65346875 NA 0.94 9.49 0.5 1.39e-18 Pediatric areal bone mineral density (radius); CESC cis rs8180040 0.967 rs4858856 chr3:47565424 G/A cg27129171 chr3:47204927 SETD2 0.6 8.5 0.46 1.36e-15 Colorectal cancer; CESC cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg12365402 chr11:9010492 NRIP3 0.43 7.08 0.4 1.29e-11 Hemoglobin concentration; CESC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg27266027 chr21:40555129 PSMG1 0.46 5.59 0.32 5.74e-8 Cognitive function; CESC cis rs2274273 0.870 rs7160523 chr14:55594560 G/T cg04306507 chr14:55594613 LGALS3 0.29 5.71 0.33 3.08e-8 Protein biomarker; CESC cis rs9372253 0.645 rs7753212 chr6:110700229 T/C cg19196401 chr6:110721138 DDO -0.39 -5.66 -0.33 3.99e-8 Platelet distribution width; CESC cis rs10779751 0.734 rs2791649 chr1:11132561 A/G cg08854313 chr1:11322531 MTOR 0.76 10.24 0.53 5.91e-21 Body mass index; CESC cis rs4975616 0.686 rs37008 chr5:1351538 C/T cg06550200 chr5:1325588 CLPTM1L -0.61 -9.39 -0.5 2.89e-18 Lung cancer; CESC trans rs9354308 0.866 rs2814092 chr6:66547346 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 6.62 0.38 1.93e-10 Metabolite levels; CESC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg24531977 chr5:56204891 C5orf35 -0.88 -11.52 -0.58 3.54e-25 Initial pursuit acceleration; CESC cis rs11871801 0.560 rs8074296 chr17:40583421 A/G cg21433558 chr17:40837037 CNTNAP1 0.46 5.96 0.34 8.13e-9 Crohn's disease; CESC cis rs8031584 1.000 rs35607976 chr15:31277788 T/C cg14829155 chr15:31115871 NA -0.77 -9.8 -0.52 1.49e-19 Huntington's disease progression; CESC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg15445000 chr17:37608096 MED1 -0.39 -6.26 -0.36 1.53e-9 Glomerular filtration rate (creatinine); CESC cis rs72945132 0.714 rs57320340 chr11:70160010 G/C cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs11997175 1.000 rs7464996 chr8:33770925 G/T ch.8.33884649F chr8:33765107 NA 0.64 8.33 0.46 4.36e-15 Body mass index; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03970961 chr1:154292240 AQP10 -0.39 -6.28 -0.36 1.4e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg09658497 chr7:2847517 GNA12 -0.34 -5.28 -0.31 2.73e-7 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00502555 chr19:1103806 GPX4 -0.4 -6.06 -0.35 4.7e-9 Gambling; CESC cis rs11203032 0.831 rs2863216 chr10:90941937 C/T cg16672925 chr10:90967113 CH25H 0.68 6.99 0.39 2.24e-11 Heart failure; CESC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9905704 0.918 rs304293 chr17:56823298 T/G cg12560992 chr17:57184187 TRIM37 0.61 7.12 0.4 9.95e-12 Testicular germ cell tumor; CESC cis rs4835473 0.808 rs4054643 chr4:144708482 A/G cg25736465 chr4:144833511 NA -0.35 -5.61 -0.33 5e-8 Immature fraction of reticulocytes; CESC cis rs2228479 0.850 rs62054611 chr16:89817017 T/C cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26381048 chr12:132632420 NOC4L 0.54 7.88 0.44 8.62e-14 Fibrinogen levels; CESC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7246657 0.882 rs8112610 chr19:37928730 C/A cg23950597 chr19:37808831 NA -0.54 -5.89 -0.34 1.17e-8 Coronary artery calcification; CESC cis rs72781680 1.000 rs72781658 chr2:24220141 A/G cg08917208 chr2:24149416 ATAD2B 1.13 9.89 0.52 7.76e-20 Lymphocyte counts; CESC trans rs61931739 0.534 rs11053049 chr12:34164537 T/C cg26384229 chr12:38710491 ALG10B 0.64 9.03 0.49 3.54e-17 Morning vs. evening chronotype; CESC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg11301795 chr4:187892539 NA -0.75 -12.51 -0.61 1.63e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs2239547 0.657 rs2072391 chr3:52862200 C/T cg11645453 chr3:52864694 ITIH4 0.32 5.89 0.34 1.15e-8 Schizophrenia; CESC cis rs7927771 1.000 rs4752797 chr11:47874364 C/T cg18512352 chr11:47633146 NA -0.55 -8.66 -0.47 4.6e-16 Subjective well-being; CESC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC cis rs2710642 0.721 rs6757128 chr2:62891752 C/T cg17519650 chr2:63277830 OTX1 -0.56 -6.91 -0.39 3.59e-11 LDL cholesterol levels;LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01888129 chr15:64126210 HERC1 0.62 7.6 0.42 5.05e-13 Gut microbiome composition (summer); CESC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg05368731 chr17:41323189 NBR1 0.78 10.63 0.55 3.32e-22 Menopause (age at onset); CESC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.21 -0.3 3.78e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg25072359 chr17:41440525 NA 0.48 6.46 0.37 4.98e-10 Menopause (age at onset); CESC cis rs56046484 0.912 rs12914674 chr15:85663060 A/C cg08123816 chr15:85640762 PDE8A -0.5 -6.15 -0.35 2.81e-9 Testicular germ cell tumor; CESC cis rs3820928 1.000 rs2163041 chr2:227772480 T/C cg05526886 chr2:227700861 RHBDD1 -0.42 -5.54 -0.32 7.19e-8 Pulmonary function; CESC cis rs9911578 0.874 rs302865 chr17:56756977 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.05 0.68 2.08e-37 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg26335602 chr6:28129616 ZNF389 0.54 7.3 0.41 3.37e-12 Depression; CESC cis rs6430585 0.583 rs76097170 chr2:136593498 C/T cg07169764 chr2:136633963 MCM6 1.28 19.03 0.76 1.69e-51 Corneal structure; CESC cis rs116095464 0.558 rs7730700 chr5:264713 G/A cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.51e-10 Breast cancer; CESC cis rs9300255 0.782 rs12809602 chr12:123768916 T/G cg00376283 chr12:123451042 ABCB9 -0.61 -6.35 -0.36 9.35e-10 Neutrophil percentage of white cells; CESC cis rs959260 1.000 rs2053158 chr17:73393459 A/T cg12999837 chr17:73267436 MIF4GD 0.46 5.34 0.31 1.98e-7 Systemic lupus erythematosus; CESC cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg08645402 chr16:4508243 NA 0.42 5.92 0.34 1.01e-8 Schizophrenia; CESC cis rs2519796 0.562 rs2519112 chr9:136811747 A/G cg13751417 chr9:136814406 VAV2 -0.42 -5.32 -0.31 2.2e-7 Hematocrit;Hemoglobin concentration; CESC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg04267008 chr7:1944627 MAD1L1 -0.59 -7.47 -0.42 1.16e-12 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21101222 chr5:151138161 ATOX1 0.61 7.14 0.4 9.23e-12 Gut microbiome composition (summer); CESC cis rs2276314 0.857 rs8097597 chr18:33619448 A/G cg19628046 chr18:33552617 C18orf21 0.49 5.74 0.33 2.64e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs4919694 1.000 rs4917986 chr10:104630181 T/C cg04362960 chr10:104952993 NT5C2 0.73 6.43 0.37 5.81e-10 Arsenic metabolism; CESC cis rs523522 0.926 rs10849766 chr12:121025894 G/A cg27279351 chr12:120934652 DYNLL1 0.7 9.1 0.49 2.31e-17 High light scatter reticulocyte count; CESC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg00684032 chr4:1343700 KIAA1530 0.39 5.44 0.32 1.19e-7 Obesity-related traits; CESC cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg17971929 chr21:40555470 PSMG1 0.59 7.62 0.42 4.4e-13 Cognitive function; CESC cis rs826838 0.834 rs2387842 chr12:38736442 T/C cg26384229 chr12:38710491 ALG10B 0.84 14.7 0.67 3.46e-36 Heart rate; CESC cis rs1577917 0.958 rs11755642 chr6:86450066 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -7.32 -0.41 2.99e-12 Response to antipsychotic treatment; CESC cis rs425277 1.000 rs262667 chr1:2082722 T/C cg16545954 chr1:2118288 C1orf86 0.33 5.58 0.32 5.82e-8 Height; CESC cis rs6674176 0.628 rs3791116 chr1:44414156 T/A cg12908607 chr1:44402522 ARTN -0.45 -6.54 -0.37 3.07e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6752107 1.000 rs3828309 chr2:234180410 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 -0.38 -5.62 -0.33 4.89e-8 Crohn's disease;Inflammatory bowel disease; CESC trans rs11039798 0.588 rs11039807 chr11:48549391 T/A cg15704280 chr7:45808275 SEPT13 0.65 6.75 0.38 9.47e-11 Axial length; CESC cis rs7216064 1.000 rs12452511 chr17:65832576 A/G cg12091567 chr17:66097778 LOC651250 -0.83 -8.29 -0.45 5.88e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs62229266 0.835 rs998384 chr21:37445526 G/C cg08632701 chr21:37451849 NA -0.41 -5.65 -0.33 4.13e-8 Mitral valve prolapse; CESC trans rs9929218 0.954 rs9929479 chr16:68821271 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.68 -8.65 -0.47 4.98e-16 Colorectal cancer; CESC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg05564831 chr3:52568323 NT5DC2 0.44 6.76 0.38 9e-11 Bipolar disorder; CESC cis rs1355223 1.000 rs2221720 chr11:34754921 C/T cg11058730 chr11:34937778 PDHX;APIP 0.42 5.53 0.32 7.58e-8 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg24101359 chr6:42928495 GNMT -0.56 -8.09 -0.44 2.19e-14 Alzheimer's disease in APOE e4+ carriers; CESC cis rs977987 0.778 rs35415181 chr16:75403124 T/C cg03315344 chr16:75512273 CHST6 0.4 5.74 0.33 2.54e-8 Dupuytren's disease; CESC cis rs1707322 0.717 rs1972410 chr1:46080947 G/T cg05343316 chr1:45956843 TESK2 0.47 5.74 0.33 2.6e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 0.906 rs2270609 chr8:58194684 G/A cg24829409 chr8:58192753 C8orf71 -0.75 -9.61 -0.51 6.02e-19 Developmental language disorder (linguistic errors); CESC cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.79 10.18 0.53 9.36e-21 Multiple sclerosis; CESC cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg14664628 chr15:75095509 CSK 0.55 7.56 0.42 6.62e-13 Breast cancer; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg08355568 chr6:7108248 RREB1 0.51 6.24 0.36 1.74e-9 Bronchopulmonary dysplasia; CESC cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg20701182 chr2:24300061 SF3B14 0.94 10.39 0.54 2.01e-21 Lymphocyte counts; CESC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg27478167 chr7:817139 HEATR2 -0.53 -5.67 -0.33 3.82e-8 Cerebrospinal P-tau181p levels; CESC cis rs7395581 0.918 rs10838692 chr11:47345100 T/C cg25783544 chr11:47291846 MADD 0.59 7.68 0.43 3.03e-13 HDL cholesterol; CESC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg05368731 chr17:41323189 NBR1 -0.57 -8.05 -0.44 2.88e-14 Menopause (age at onset); CESC cis rs4919694 0.611 rs2271750 chr10:105174869 A/G cg04362960 chr10:104952993 NT5C2 -0.62 -6.04 -0.35 5.26e-9 Arsenic metabolism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07747791 chr7:27498134 NA -0.51 -6.48 -0.37 4.42e-10 Gut microbiome composition (summer); CESC cis rs7116495 0.609 rs2503 chr11:71719403 C/T cg26138937 chr11:71823887 C11orf51 1.25 8.83 0.48 1.44e-16 Severe influenza A (H1N1) infection; CESC cis rs1218582 0.600 rs72702224 chr1:154911689 G/A cg24250549 chr1:154909240 PMVK 0.56 7.5 0.42 9.77e-13 Prostate cancer; CESC cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg12373951 chr3:133503437 NA 0.52 7.75 0.43 2.01e-13 Iron status biomarkers; CESC cis rs1570884 0.516 rs2146144 chr13:50170245 C/T cg08779649 chr13:50194554 NA 0.39 6.71 0.38 1.17e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs11190604 1.000 rs2495741 chr10:102331795 A/G cg07080220 chr10:102295463 HIF1AN 0.58 5.64 0.33 4.47e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27210852 chr21:46685308 POFUT2 -0.52 -6.11 -0.35 3.5e-9 Gut microbiome composition (summer); CESC cis rs2274273 0.967 rs1009978 chr14:55603061 C/G cg04306507 chr14:55594613 LGALS3 0.3 6.0 0.35 6.51e-9 Protein biomarker; CESC cis rs9486719 1.000 rs12212614 chr6:97036466 T/G cg18709589 chr6:96969512 KIAA0776 -0.5 -5.44 -0.32 1.21e-7 Migraine;Coronary artery disease; CESC trans rs561341 0.941 rs2428341 chr17:30317295 C/T cg27661571 chr11:113659931 NA -0.56 -6.3 -0.36 1.24e-9 Hip circumference adjusted for BMI; CESC cis rs2760061 0.626 rs591582 chr1:228117360 C/A cg02753203 chr1:228287806 NA -0.5 -7.24 -0.41 4.83e-12 Diastolic blood pressure; CESC cis rs924607 0.966 rs1621827 chr5:635074 A/G cg09021430 chr5:549028 NA -0.39 -6.86 -0.39 4.95e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg04944784 chr2:26401820 FAM59B 0.89 9.22 0.49 9.53e-18 Gut microbiome composition (summer); CESC cis rs10242455 0.571 rs7805661 chr7:99171522 A/C cg25640893 chr7:99214727 ZNF498 0.73 5.73 0.33 2.68e-8 Blood metabolite levels; CESC cis rs1707322 1.000 rs11211222 chr1:46367757 T/C cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7621025 0.675 rs34602896 chr3:136346385 A/G cg15507776 chr3:136538369 TMEM22 -0.51 -5.48 -0.32 1.01e-7 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.62 -8.04 -0.44 2.94e-14 Tonsillectomy; CESC cis rs733592 0.929 rs4760678 chr12:48461581 T/C cg24011408 chr12:48396354 COL2A1 -0.51 -7.79 -0.43 1.55e-13 Plateletcrit; CESC cis rs8114671 0.904 rs6060197 chr20:33654315 C/T cg06115741 chr20:33292138 TP53INP2 -0.44 -5.31 -0.31 2.27e-7 Height; CESC cis rs7714584 1.000 rs11749391 chr5:150229066 T/C cg22134413 chr5:150180641 NA 0.53 5.84 0.34 1.49e-8 Crohn's disease; CESC cis rs7917772 0.503 rs7902306 chr10:104290462 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.51 6.67 0.38 1.46e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg26354017 chr1:205819088 PM20D1 0.85 12.61 0.61 6.88e-29 Menarche (age at onset); CESC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg04414720 chr1:150670196 GOLPH3L -0.55 -7.46 -0.42 1.26e-12 Melanoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12503190 chr17:74733672 MIR636;SFRS2;MFSD11 0.59 6.62 0.38 1.98e-10 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.45 0.37 5.34e-10 Prudent dietary pattern; CESC cis rs8050907 0.744 rs28629405 chr16:4525933 G/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg22535103 chr8:58192502 C8orf71 -1.04 -13.21 -0.63 5.76e-31 Developmental language disorder (linguistic errors); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13327952 chr7:90032561 CLDN12 0.45 6.45 0.37 5.38e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2742234 0.541 rs871763 chr10:43734188 C/T cg07801480 chr10:43725741 RASGEF1A -0.41 -5.3 -0.31 2.47e-7 Hirschsprung disease; CESC cis rs2180341 0.920 rs1073932 chr6:127682009 G/T cg24812749 chr6:127587940 RNF146 1.05 15.15 0.68 9.37e-38 Breast cancer; CESC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg07701084 chr6:150067640 NUP43 0.46 6.45 0.37 5.26e-10 Lung cancer; CESC cis rs7833986 0.501 rs2719227 chr8:57043794 A/G cg23139584 chr8:56987506 RPS20;SNORD54 -0.59 -7.45 -0.42 1.3e-12 Height; CESC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg08888203 chr3:10149979 C3orf24 0.51 6.44 0.37 5.71e-10 Alzheimer's disease; CESC cis rs35306767 0.903 rs12764024 chr10:922861 A/G cg20503657 chr10:835505 NA 0.72 7.48 0.42 1.07e-12 Eosinophil percentage of granulocytes; CESC cis rs2635047 0.967 rs3816125 chr18:44601611 C/T cg19077165 chr18:44547161 KATNAL2 0.45 5.45 0.32 1.13e-7 Educational attainment; CESC cis rs1355223 0.583 rs2941041 chr11:34874734 A/C cg11058730 chr11:34937778 PDHX;APIP 0.84 12.9 0.62 6.88e-30 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg05347473 chr6:146136440 FBXO30 -0.52 -6.77 -0.38 8.3e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2109514 1.000 rs7795510 chr7:116156961 T/C cg12739419 chr7:116140593 CAV2 -0.36 -6.54 -0.37 3.15e-10 Prevalent atrial fibrillation; CESC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7264396 0.635 rs6060681 chr20:34506147 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.78 -10.8 -0.55 8.73e-23 Total cholesterol levels; CESC trans rs11098499 0.954 rs34858317 chr4:120387110 A/C cg25214090 chr10:38739885 LOC399744 0.7 9.93 0.52 5.63e-20 Corneal astigmatism; CESC cis rs9888739 0.800 rs1143678 chr16:31343005 C/T cg15817542 chr16:31343056 ITGAM -0.54 -7.68 -0.43 3.13e-13 Systemic lupus erythematosus; CESC cis rs8180040 0.726 rs4234465 chr3:47026885 C/G cg27129171 chr3:47204927 SETD2 0.61 8.52 0.46 1.24e-15 Colorectal cancer; CESC cis rs9888739 1.000 rs12928810 chr16:31311715 G/A cg15817542 chr16:31343056 ITGAM -0.43 -5.54 -0.32 7.48e-8 Systemic lupus erythematosus; CESC cis rs9611565 0.649 rs5758466 chr22:42176059 G/A cg06634786 chr22:41940651 POLR3H 0.46 5.06 0.3 7.69e-7 Vitiligo; CESC cis rs6991838 0.557 rs4737222 chr8:66500113 G/T cg13398993 chr8:66546079 ARMC1 -0.48 -5.77 -0.33 2.26e-8 Intelligence (multi-trait analysis); CESC cis rs1003719 0.788 rs2040341 chr21:38489753 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.7 0.47 3.66e-16 Eye color traits; CESC cis rs9291683 0.546 rs7442336 chr4:10045783 G/A cg00071950 chr4:10020882 SLC2A9 0.81 13.65 0.64 1.8e-32 Bone mineral density; CESC cis rs11958404 0.932 rs72816564 chr5:157427484 T/C cg05962755 chr5:157440814 NA 0.62 6.53 0.37 3.41e-10 IgG glycosylation; CESC cis rs11098499 0.954 rs2892848 chr4:120381341 C/T cg24375607 chr4:120327624 NA 0.45 5.54 0.32 7.19e-8 Corneal astigmatism; CESC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg14393609 chr7:65229607 NA -0.46 -6.17 -0.35 2.6e-9 Aortic root size; CESC trans rs2727020 0.575 rs10769587 chr11:49549849 C/G cg15704280 chr7:45808275 SEPT13 -0.94 -16.08 -0.7 4.42e-41 Coronary artery disease; CESC cis rs7178572 1.000 rs8024485 chr15:77718368 C/A cg22256960 chr15:77711686 NA -0.59 -7.96 -0.44 5e-14 Type 2 diabetes; CESC cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg20503657 chr10:835505 NA 0.74 7.52 0.42 8.76e-13 Eosinophil percentage of granulocytes; CESC trans rs10496702 0.818 rs17800749 chr2:134003754 C/T cg01707976 chr16:4991230 NA 0.49 6.02 0.35 5.7e-9 Bipolar disorder and schizophrenia; CESC cis rs11864453 0.647 rs10492813 chr16:72122463 A/G cg01557791 chr16:72042693 DHODH 0.43 5.63 0.33 4.58e-8 Fibrinogen levels; CESC cis rs1499614 1.000 rs2141924 chr7:66186246 C/T cg18252515 chr7:66147081 NA -1.42 -14.62 -0.67 6.69e-36 Gout; CESC cis rs2985684 0.895 rs3007033 chr14:50103816 T/C cg15316458 chr14:50087796 RPL36AL;MGAT2 0.46 5.19 0.3 4.19e-7 Carotid intima media thickness; CESC cis rs938554 0.571 rs7696092 chr4:10025320 C/A cg11266682 chr4:10021025 SLC2A9 0.57 8.13 0.45 1.63e-14 Blood metabolite levels; CESC cis rs7116495 0.609 rs567026 chr11:71769952 C/T cg18441811 chr11:71824068 C11orf51 0.79 5.1 0.3 6.47e-7 Severe influenza A (H1N1) infection; CESC cis rs11997175 0.524 rs10954932 chr8:33650176 A/C ch.8.33884649F chr8:33765107 NA 0.65 8.33 0.46 4.44e-15 Body mass index; CESC cis rs3820928 0.874 rs2396452 chr2:227838040 T/G cg05526886 chr2:227700861 RHBDD1 -0.44 -5.53 -0.32 7.61e-8 Pulmonary function; CESC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.84 0.62 1.18e-29 Alzheimer's disease; CESC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg13126279 chr21:47581558 C21orf56 -0.48 -6.54 -0.37 3.1e-10 Testicular germ cell tumor; CESC cis rs4699052 0.739 rs6836157 chr4:104242990 A/G cg16532752 chr4:104119610 CENPE -0.38 -5.35 -0.31 1.87e-7 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00814883 chr7:100076585 TSC22D4 0.62 7.27 0.41 4e-12 Gut microbiome composition (summer); CESC cis rs7223966 1.000 rs8076717 chr17:61850301 C/T cg11494091 chr17:61959527 GH2 -0.38 -5.1 -0.3 6.36e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1348850 0.651 rs4893821 chr2:178229352 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.66 -9.11 -0.49 2.07e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs12586317 0.547 rs112510746 chr14:35491833 T/G cg05294307 chr14:35346193 BAZ1A -0.51 -5.4 -0.31 1.49e-7 Psoriasis; CESC trans rs11098499 0.818 rs10008791 chr4:120431469 A/C cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.54e-19 Corneal astigmatism; CESC cis rs910316 1.000 rs910316 chr14:75626042 A/C cg11812906 chr14:75593930 NEK9 0.9 14.82 0.67 1.35e-36 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23814154 chr12:51611356 POU6F1 -0.5 -6.86 -0.39 4.87e-11 Gut microbiota (bacterial taxa); CESC cis rs1878931 0.582 rs27232 chr16:3436782 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.68 -8.23 -0.45 8.3e-15 Body mass index (adult); CESC cis rs12545109 0.800 rs2221919 chr8:57412541 A/C cg09654669 chr8:57350985 NA -0.46 -6.28 -0.36 1.4e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18099850 chr8:22993352 TNFRSF10D -0.54 -6.36 -0.36 8.79e-10 Gut microbiome composition (summer); CESC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg22968622 chr17:43663579 NA -0.73 -9.94 -0.52 5.42e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg11987759 chr7:65425863 GUSB -0.47 -6.25 -0.36 1.62e-9 Calcium levels; CESC cis rs911555 0.755 rs7147664 chr14:103963420 G/A cg09975044 chr14:104007538 NA 0.43 5.31 0.31 2.33e-7 Intelligence (multi-trait analysis); CESC cis rs3785574 0.621 rs1051684 chr17:62006497 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.82 -11.83 -0.59 3.34e-26 Height; CESC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg05368731 chr17:41323189 NBR1 0.52 7.34 0.41 2.56e-12 Menopause (age at onset); CESC cis rs2635047 0.967 rs2571001 chr18:44665083 C/A cg19077165 chr18:44547161 KATNAL2 -0.44 -5.81 -0.34 1.83e-8 Educational attainment; CESC cis rs6496667 0.565 rs7162107 chr15:90889046 A/G cg22089800 chr15:90895588 ZNF774 0.5 6.11 0.35 3.56e-9 Rheumatoid arthritis; CESC cis rs9926296 0.593 rs6500456 chr16:89888341 T/C cg03388025 chr16:89894329 SPIRE2 0.31 5.47 0.32 1.07e-7 Vitiligo; CESC cis rs703842 0.616 rs4760332 chr12:58222672 A/C cg00677455 chr12:58241039 CTDSP2 -0.74 -10.06 -0.53 2.31e-20 Multiple sclerosis; CESC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg14893161 chr1:205819251 PM20D1 -0.4 -5.34 -0.31 1.98e-7 Parkinson's disease; CESC trans rs35851103 0.600 rs4841662 chr8:11843758 A/G cg15556689 chr8:8085844 FLJ10661 -0.52 -6.45 -0.37 5.18e-10 Neuroticism; CESC cis rs8114671 0.836 rs1885114 chr20:33577361 A/G cg24642439 chr20:33292090 TP53INP2 -0.42 -5.04 -0.3 8.62e-7 Height; CESC cis rs1215050 0.904 rs2903153 chr4:99057457 C/T cg05340658 chr4:99064831 C4orf37 0.55 6.83 0.39 5.65e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7223966 1.000 rs73337598 chr17:61732576 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.4 0.41 1.86e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1707322 0.752 rs6658700 chr1:46160260 C/T cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12042938 0.935 rs1094653 chr1:231794794 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.47 6.5 0.37 3.89e-10 Neuranatomic and neurocognitive phenotypes; CESC cis rs6831352 0.918 rs2851248 chr4:100045974 A/G cg12011299 chr4:100065546 ADH4 0.57 6.49 0.37 4.09e-10 Alcohol dependence; CESC cis rs3806843 0.868 rs2531352 chr5:140119534 A/G cg26395211 chr5:140044315 WDR55 0.4 5.17 0.3 4.58e-7 Depressive symptoms (multi-trait analysis); CESC cis rs73206853 0.764 rs3026425 chr12:110688168 A/G cg12870014 chr12:110450643 ANKRD13A 0.64 5.37 0.31 1.75e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.46 6.2 0.36 2.13e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.76 6.69 0.38 1.3e-10 Platelet count; CESC cis rs11168351 0.864 rs10875743 chr12:48498413 C/T cg24011408 chr12:48396354 COL2A1 -0.5 -7.63 -0.42 4.18e-13 Bipolar disorder and schizophrenia; CESC cis rs17431357 1.000 rs73230318 chr12:120997937 T/C cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs2236918 0.687 rs2797601 chr1:242029249 C/G cg17736920 chr1:242011382 EXO1 0.55 6.97 0.39 2.5e-11 Menopause (age at onset); CESC cis rs34638657 0.673 rs11645286 chr16:82201898 C/A cg09439754 chr16:82129088 HSD17B2 -0.35 -6.28 -0.36 1.39e-9 Lung adenocarcinoma; CESC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.73 9.92 0.52 6.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs950169 0.922 rs4842940 chr15:84831225 C/T cg17507749 chr15:85114479 UBE2QP1 -0.55 -6.25 -0.36 1.66e-9 Schizophrenia; CESC cis rs12586317 0.547 rs115019197 chr14:35503764 G/A cg16230307 chr14:35515116 FAM177A1 0.99 10.61 0.55 3.72e-22 Psoriasis; CESC cis rs16870629 0.541 rs2334955 chr5:1062444 A/G cg00278107 chr5:1061253 SLC12A7 -0.69 -10.79 -0.55 9.44e-23 QT interval; CESC cis rs6665290 0.904 rs6684821 chr1:227190233 G/A cg10327440 chr1:227177885 CDC42BPA -1.21 -30.96 -0.89 5.21e-90 Myeloid white cell count; CESC cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg13319975 chr6:146136371 FBXO30 -0.42 -5.26 -0.31 3.01e-7 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09800975 chr10:6130861 RBM17 0.46 6.19 0.36 2.32e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs4332037 0.539 rs11764590 chr7:2032803 C/T cg11693508 chr17:37793320 STARD3 0.65 6.51 0.37 3.72e-10 Bipolar disorder; CESC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg14664628 chr15:75095509 CSK -0.56 -7.58 -0.42 6e-13 Breast cancer; CESC cis rs57083693 0.518 rs7975348 chr12:101701930 T/C cg22051763 chr12:101673672 UTP20 -0.44 -5.5 -0.32 8.8e-8 Alcohol dependence (age at onset); CESC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg21017887 chr14:105400489 NA 0.41 6.67 0.38 1.45e-10 Rheumatoid arthritis; CESC cis rs6493487 0.512 rs11856129 chr15:51172604 T/C cg02338191 chr15:51200825 AP4E1 0.6 5.58 0.32 5.79e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs67311347 1.000 rs11716675 chr3:40485280 G/T cg24209194 chr3:40518798 ZNF619 0.46 5.99 0.35 6.78e-9 Renal cell carcinoma; CESC cis rs763014 0.931 rs2071980 chr16:626346 A/C cg00802000 chr16:706648 WDR90 -0.41 -6.09 -0.35 3.94e-9 Height; CESC cis rs1559088 0.947 rs12461219 chr19:33550633 C/G cg27124370 chr19:33622961 WDR88 0.42 5.34 0.31 1.99e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs11098499 0.866 rs12513310 chr4:120288039 T/A cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs2629540 0.824 rs1552345 chr10:126477406 A/G cg08799069 chr10:126477246 METTL10 -0.69 -9.41 -0.5 2.51e-18 Cocaine dependence; CESC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg10691866 chr7:65817282 TPST1 -0.36 -6.1 -0.35 3.77e-9 Aortic root size; CESC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg01879757 chr17:41196368 BRCA1 0.37 5.17 0.3 4.61e-7 Menopause (age at onset); CESC cis rs12579753 0.719 rs4418884 chr12:82277006 C/T cg21193143 chr12:82153300 PPFIA2 -0.35 -5.35 -0.31 1.92e-7 Resting heart rate; CESC cis rs9303401 0.614 rs34900851 chr17:56566399 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.07 0.6 4.86e-27 Cognitive test performance; CESC cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 -0.85 -12.5 -0.61 1.71e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2404602 0.692 rs10444858 chr15:76962504 T/C cg26408565 chr15:76604113 ETFA -0.39 -5.58 -0.32 5.8e-8 Blood metabolite levels; CESC trans rs116095464 0.558 rs9688136 chr5:229348 T/C cg00938859 chr5:1591904 SDHAP3 0.61 6.74 0.38 9.82e-11 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02607779 chr2:208030673 KLF7 0.54 6.33 0.36 1.05e-9 Gut microbiome composition (summer); CESC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg08392591 chr16:89556376 ANKRD11 0.45 5.9 0.34 1.08e-8 Multiple myeloma (IgH translocation); CESC cis rs863345 0.604 rs10797013 chr1:158465506 G/C cg12129480 chr1:158549410 OR10X1 -0.35 -7.03 -0.4 1.78e-11 Pneumococcal bacteremia; CESC cis rs6570726 0.934 rs9484995 chr6:145781114 T/A cg23711669 chr6:146136114 FBXO30 -0.72 -10.53 -0.54 6.67e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs2425143 1.000 rs6058325 chr20:34388806 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.93 0.34 9.19e-9 Blood protein levels; CESC cis rs2985684 1.000 rs17121651 chr14:50097172 T/C cg02151108 chr14:50098012 C14orf104 -0.42 -5.65 -0.33 4.16e-8 Carotid intima media thickness; CESC cis rs3105593 0.563 rs12909531 chr15:50964832 T/C cg08437265 chr15:50716283 USP8 0.41 5.2 0.3 4e-7 QT interval; CESC cis rs6662572 1.000 rs28584711 chr1:46212631 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 5.55 0.32 7.08e-8 Blood protein levels; CESC cis rs6088590 0.813 rs1884668 chr20:33285514 A/G cg08999081 chr20:33150536 PIGU 0.64 10.56 0.54 5.39e-22 Coronary artery disease; CESC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg05564831 chr3:52568323 NT5DC2 0.46 7.17 0.4 7.29e-12 Bipolar disorder; CESC cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg00149659 chr3:10157352 C3orf10 1.01 12.05 0.59 5.88e-27 Alzheimer's disease; CESC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.27 0.31 2.8e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9649465 1.000 rs6466881 chr7:123337734 G/C cg04330084 chr7:123175371 IQUB -0.38 -5.16 -0.3 4.75e-7 Migraine; CESC cis rs11098499 0.863 rs3822191 chr4:120428101 A/T cg24375607 chr4:120327624 NA 0.44 5.25 0.31 3.13e-7 Corneal astigmatism; CESC cis rs72720396 0.694 rs6689362 chr1:91203251 T/A cg13456504 chr1:91191583 NA -0.36 -5.54 -0.32 7.18e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg23583168 chr7:148888333 NA -0.73 -10.02 -0.52 2.91e-20 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6570726 0.935 rs411641 chr6:145827532 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.36e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1144333 1.000 rs1144333 chr1:76275100 A/G cg10523679 chr1:76189770 ACADM -0.59 -5.59 -0.32 5.69e-8 Attention function in attention deficit hyperactive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25008346 chr17:40118675 CNP 0.55 6.51 0.37 3.74e-10 Gut microbiome composition (summer); CESC cis rs7188697 0.922 rs37056 chr16:58560877 G/A cg02549819 chr16:58548995 SETD6 -0.41 -5.21 -0.3 3.79e-7 QT interval; CESC cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg18904891 chr8:8559673 CLDN23 0.44 5.58 0.32 5.82e-8 Mood instability; CESC cis rs10979 1.000 rs9390107 chr6:143892721 A/T cg25407410 chr6:143891975 LOC285740 -0.61 -9.21 -0.49 1.01e-17 Hypospadias; CESC cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg24690094 chr11:67383802 NA 0.38 6.26 0.36 1.55e-9 Mean corpuscular volume; CESC cis rs3204270 1.000 rs3204270 chr17:79682051 C/T cg18367735 chr17:79674897 NA 0.74 5.34 0.31 2.04e-7 Dental caries; CESC cis rs9815354 1.000 rs10212536 chr3:41827026 A/G cg03022575 chr3:42003672 ULK4 0.47 5.12 0.3 5.95e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs861020 1.000 rs674433 chr1:209964875 A/C cg05527609 chr1:210001259 C1orf107 -0.99 -12.29 -0.6 9.17e-28 Orofacial clefts; CESC cis rs1003719 0.715 rs8128387 chr21:38556787 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.13 -0.45 1.62e-14 Eye color traits; CESC cis rs2710642 0.779 rs360807 chr2:62926859 C/T cg17519650 chr2:63277830 OTX1 -0.6 -7.72 -0.43 2.43e-13 LDL cholesterol levels;LDL cholesterol; CESC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.17e-9 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25003565 chr1:150207434 ANP32E 0.65 7.21 0.4 5.69e-12 Gut microbiome composition (summer); CESC cis rs7809950 0.678 rs12670688 chr7:106821016 A/G cg23024343 chr7:107201750 COG5 0.6 6.84 0.39 5.58e-11 Coronary artery disease; CESC cis rs6484504 0.532 rs12788257 chr11:31255045 T/C cg14844989 chr11:31128820 NA -0.41 -5.69 -0.33 3.28e-8 Red blood cell count; CESC cis rs6547741 0.935 rs12615690 chr2:27851120 T/C cg21248554 chr2:27665150 KRTCAP3 0.25 5.18 0.3 4.47e-7 Oral cavity cancer; CESC cis rs72627509 0.857 rs2227901 chr4:57798189 A/G cg26694713 chr4:57773883 REST -0.58 -5.86 -0.34 1.37e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7726839 0.561 rs4957050 chr5:579066 A/C cg16447950 chr5:562315 NA -0.58 -6.74 -0.38 9.99e-11 Obesity-related traits; CESC cis rs7267979 0.834 rs6115100 chr20:25225938 C/A cg08601574 chr20:25228251 PYGB 0.44 6.36 0.36 8.57e-10 Liver enzyme levels (alkaline phosphatase); CESC cis rs3741151 1.000 rs75912489 chr11:73073846 G/A cg17517138 chr11:73019481 ARHGEF17 1.0 6.71 0.38 1.18e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs6540559 0.611 rs61747285 chr1:210004332 G/A cg21951975 chr1:209979733 IRF6 0.58 6.68 0.38 1.39e-10 Cleft lip with or without cleft palate; CESC cis rs1008375 0.966 rs3775927 chr4:17599894 G/T cg02297831 chr4:17616191 MED28 0.45 5.45 0.32 1.13e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7762018 0.655 rs11966349 chr6:170162537 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 -0.51 -5.4 -0.31 1.49e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs77956314 0.515 rs60940473 chr12:117462582 C/T cg02017074 chr12:117425053 FBXW8 -0.82 -8.44 -0.46 2.13e-15 Subcortical brain region volumes;Hippocampal volume; CESC cis rs7927592 0.913 rs4084149 chr11:68288567 A/G cg16797656 chr11:68205561 LRP5 0.37 5.04 0.3 8.47e-7 Total body bone mineral density; CESC cis rs16867321 0.627 rs2042551 chr2:181579141 A/C cg23363182 chr2:181467187 NA 0.44 6.53 0.37 3.28e-10 Obesity; CESC trans rs7937682 0.883 rs11213941 chr11:111434094 T/C cg18187862 chr3:45730750 SACM1L -0.57 -6.74 -0.38 9.63e-11 Primary sclerosing cholangitis; CESC cis rs2412819 0.599 rs2470120 chr15:43929070 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.47 7.15 0.4 8.67e-12 Lung cancer; CESC cis rs10463316 0.862 rs59390562 chr5:150776092 A/G cg03212797 chr5:150827313 SLC36A1 -0.45 -5.94 -0.34 9.07e-9 Metabolite levels (Pyroglutamine); CESC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg17971929 chr21:40555470 PSMG1 1.06 16.47 0.71 1.87e-42 Cognitive function; CESC cis rs7818345 0.967 rs12679712 chr8:19271032 C/G cg11303988 chr8:19266685 CSGALNACT1 0.34 6.18 0.35 2.46e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs2276314 1.000 rs2298716 chr18:33552598 C/T cg05985134 chr18:33552581 C18orf21 0.66 7.82 0.43 1.28e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs8077577 0.945 rs11656035 chr17:18086025 T/C cg16794390 chr17:18148240 FLII 0.42 5.6 0.33 5.42e-8 Obesity-related traits; CESC cis rs9796 0.689 rs28409432 chr15:41447454 G/A cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.87 -0.39 4.48e-11 Menopause (age at onset); CESC cis rs3820068 0.581 rs72645890 chr1:15930602 A/G cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs1023500 0.573 rs133377 chr22:42466950 C/T cg04733989 chr22:42467013 NAGA 0.83 12.6 0.61 7.88e-29 Schizophrenia; CESC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg16145915 chr7:1198662 ZFAND2A -0.48 -6.08 -0.35 4.09e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2243480 1.000 rs778691 chr7:65873092 G/C cg13147721 chr7:65941812 NA -0.95 -8.95 -0.48 6.27e-17 Diabetic kidney disease; CESC cis rs2657888 0.965 rs2657902 chr12:56933651 G/A cg23002907 chr12:56915593 RBMS2 0.39 5.15 0.3 5.11e-7 Adiponectin levels; CESC cis rs6088580 0.634 rs6120666 chr20:33090718 A/G cg24642439 chr20:33292090 TP53INP2 0.5 6.54 0.37 3.24e-10 Glomerular filtration rate (creatinine); CESC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg08888203 chr3:10149979 C3orf24 0.48 5.96 0.34 7.91e-9 Alzheimer's disease; CESC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg27535305 chr1:53392650 SCP2 0.35 6.14 0.35 3.05e-9 Monocyte count; CESC cis rs9902453 0.845 rs7501472 chr17:28010628 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.76 0.47 2.29e-16 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12820191 chr3:186524311 RFC4 0.54 6.33 0.36 1.04e-9 Gut microbiome composition (summer); CESC cis rs2882667 0.755 rs55650316 chr5:138467292 C/G cg04439458 chr5:138467593 SIL1 -0.34 -5.29 -0.31 2.62e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg09658497 chr7:2847517 GNA12 -0.42 -5.82 -0.34 1.67e-8 Height; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg17847749 chr12:116355168 NA -0.46 -7.03 -0.4 1.78e-11 Vertical cup-disc ratio; CESC cis rs7539409 0.764 rs4001465 chr1:84285304 T/C cg10977910 chr1:84465055 TTLL7 0.69 5.75 0.33 2.5e-8 Alzheimer's disease; CESC cis rs4889855 0.505 rs4890057 chr17:78591679 A/G cg16591659 chr17:78472290 NA -0.32 -5.17 -0.3 4.52e-7 Fractional excretion of uric acid; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg16080015 chr7:5085479 RBAK 0.48 6.14 0.35 3.05e-9 Myopia (pathological); CESC cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg07343612 chr16:622815 PIGQ -0.53 -7.71 -0.43 2.55e-13 Height; CESC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg11494091 chr17:61959527 GH2 -0.77 -12.9 -0.62 7.2e-30 Prudent dietary pattern; CESC cis rs6594499 0.872 rs10059658 chr5:110452815 T/C cg04022379 chr5:110408740 TSLP 0.33 5.7 0.33 3.24e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs3806843 0.801 rs2531358 chr5:140117437 A/G cg26395211 chr5:140044315 WDR55 0.45 5.69 0.33 3.28e-8 Depressive symptoms (multi-trait analysis); CESC cis rs4654899 0.865 rs6426674 chr1:21483906 C/T cg05370193 chr1:21551575 ECE1 0.46 7.08 0.4 1.28e-11 Superior frontal gyrus grey matter volume; CESC cis rs397969 0.646 rs8079923 chr17:19869544 C/T cg12073167 chr17:19770448 ULK2 -0.44 -5.11 -0.3 6.11e-7 Platelet count; CESC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg14664628 chr15:75095509 CSK 0.55 7.41 0.41 1.65e-12 Breast cancer; CESC trans rs9325144 0.600 rs10785621 chr12:38744912 C/T cg23762105 chr12:34175262 ALG10 -0.45 -6.02 -0.35 5.64e-9 Morning vs. evening chronotype; CESC cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.59 -7.22 -0.41 5.53e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4835473 0.663 rs4835115 chr4:144900461 G/T cg25736465 chr4:144833511 NA 0.39 6.06 0.35 4.64e-9 Immature fraction of reticulocytes; CESC cis rs11683229 0.704 rs13006926 chr2:63119967 T/C cg17519650 chr2:63277830 OTX1 -0.7 -5.83 -0.34 1.64e-8 Protein quantitative trait loci; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11887960 chr12:57824829 NA -0.47 -6.25 -0.36 1.67e-9 Fibrinogen levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10675120 chr10:75532504 FUT11 0.52 6.61 0.38 2.16e-10 Gut microbiota (bacterial taxa); CESC cis rs1580019 0.961 rs1610143 chr7:32498331 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.1 0.53 1.62e-20 Cognitive ability; CESC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs6087990 0.735 rs2424906 chr20:31359109 A/G cg13636640 chr20:31349939 DNMT3B 0.78 12.86 0.62 1.01e-29 Ulcerative colitis; CESC cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg11752832 chr7:134001865 SLC35B4 0.54 7.05 0.4 1.55e-11 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14394617 chr12:54674541 HNRNPA1;HNRPA1L-2;CBX5 -0.47 -6.75 -0.38 9.2e-11 Fibrinogen levels; CESC cis rs17253792 0.822 rs17683728 chr14:56060389 C/T cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC cis rs56399783 0.614 rs11772508 chr7:2771504 A/C cg19731401 chr7:2775893 GNA12 -0.64 -5.58 -0.32 5.9e-8 Childhood ear infection; CESC cis rs889398 0.802 rs2291959 chr16:69873992 T/G cg09409435 chr16:70099608 PDXDC2 0.42 5.3 0.31 2.47e-7 Body mass index; CESC cis rs28829049 0.570 rs12060125 chr1:19391108 A/G cg22333259 chr1:19394757 NA -0.34 -5.86 -0.34 1.36e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00983485 chr15:31284262 MTMR10 0.47 6.23 0.36 1.83e-9 Systemic lupus erythematosus; CESC cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg26597838 chr10:835615 NA 0.85 8.88 0.48 1.02e-16 Eosinophil percentage of granulocytes; CESC cis rs3026101 0.671 rs2301738 chr17:5308279 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.45 6.06 0.35 4.6e-9 Body mass index; CESC cis rs6061231 0.724 rs1570027 chr20:60968596 A/G cg22601191 chr20:60968625 CABLES2 0.53 6.24 0.36 1.73e-9 Colorectal cancer; CESC cis rs35110281 0.574 rs1836856 chr21:44964638 A/T cg21573476 chr21:45109991 RRP1B -0.39 -5.41 -0.32 1.44e-7 Mean corpuscular volume; CESC cis rs7605827 0.930 rs13033762 chr2:15592295 T/C cg19274914 chr2:15703543 NA 0.32 5.67 0.33 3.73e-8 Educational attainment (years of education); CESC trans rs4234798 0.546 rs4689667 chr4:7249188 A/T cg24688926 chr19:6737877 GPR108 0.52 6.35 0.36 9.34e-10 Insulin-like growth factors; CESC cis rs12579753 0.879 rs7971664 chr12:82264101 T/C cg23701643 chr12:82153290 PPFIA2 -0.36 -5.21 -0.3 3.89e-7 Resting heart rate; CESC cis rs10242455 0.702 rs73403247 chr7:99088730 G/A cg25640893 chr7:99214727 ZNF498 0.69 5.12 0.3 5.75e-7 Blood metabolite levels; CESC cis rs5763662 1.000 rs5753020 chr22:30524868 A/G cg21388335 chr22:29999516 NF2 -0.74 -5.03 -0.3 9.22e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs2652822 0.530 rs12595312 chr15:63494159 T/C cg02713581 chr15:63449717 RPS27L 0.47 5.58 0.32 6.07e-8 Metabolic traits; CESC cis rs7264396 1.000 rs224430 chr20:34153341 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -6.44 -0.37 5.45e-10 Total cholesterol levels; CESC cis rs9788682 0.747 rs28511883 chr15:78783683 C/T cg24631222 chr15:78858424 CHRNA5 0.62 7.26 0.41 4.19e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC cis rs11792861 0.530 rs1772047 chr9:111679012 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.38 -5.08 -0.3 7.12e-7 Menarche (age at onset); CESC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg17971929 chr21:40555470 PSMG1 -0.6 -8.05 -0.44 2.83e-14 Menarche (age at onset); CESC cis rs4901869 1.000 rs4901869 chr14:59334128 A/G cg02291164 chr14:59296302 NA 0.45 7.73 0.43 2.21e-13 Panic disorder; CESC cis rs1801251 0.778 rs809639 chr2:233731244 C/G cg25237894 chr2:233734115 C2orf82 0.53 9.24 0.49 8.49e-18 Coronary artery disease; CESC cis rs7264396 1.000 rs224434 chr20:34153856 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -6.02 -0.35 5.88e-9 Total cholesterol levels; CESC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg24531977 chr5:56204891 C5orf35 -0.87 -10.95 -0.56 2.97e-23 Initial pursuit acceleration; CESC cis rs3806843 0.676 rs2569159 chr5:140030710 C/T cg26395211 chr5:140044315 WDR55 0.53 6.78 0.38 7.57e-11 Depressive symptoms (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14330119 chr7:73668867 RFC2 -0.39 -6.02 -0.35 5.83e-9 Gambling; CESC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg09365446 chr1:150670422 GOLPH3L 0.39 5.11 0.3 6.21e-7 Melanoma; CESC cis rs9660992 0.573 rs1172159 chr1:205207512 T/C cg21643547 chr1:205240462 TMCC2 -0.38 -5.29 -0.31 2.51e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs644799 1.000 rs518919 chr11:95623313 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.59 7.21 0.4 5.87e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs35955747 0.778 rs9609263 chr22:31745274 G/T cg02404636 chr22:31891804 SFI1 -0.34 -5.04 -0.3 8.6e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs4704187 0.687 rs67065524 chr5:74534309 A/G cg03227963 chr5:74354835 NA 0.27 5.04 0.3 8.67e-7 Response to amphetamines; CESC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg00106254 chr7:1943704 MAD1L1 -0.47 -5.93 -0.34 9.22e-9 Bipolar disorder and schizophrenia; CESC cis rs79839061 0.610 rs12651271 chr4:854071 C/T cg07828340 chr4:882639 GAK 1.01 8.0 0.44 3.81e-14 Intelligence (multi-trait analysis); CESC cis rs18122 0.632 rs12713595 chr2:67523685 A/G cg09028215 chr2:67624308 ETAA1 0.42 5.28 0.31 2.68e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9868809 0.881 rs2276850 chr3:48669648 G/A cg07636037 chr3:49044803 WDR6 -0.63 -5.15 -0.3 5.14e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs7408868 0.563 rs10404382 chr19:15301389 C/A cg14696996 chr19:15285081 NOTCH3 0.96 9.76 0.51 1.98e-19 Pulse pressure; CESC cis rs7084402 0.934 rs1579394 chr10:60294625 T/A cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.35e-18 Refractive error; CESC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg22968622 chr17:43663579 NA -1.19 -16.28 -0.71 8.87e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs752010 1.000 rs6664724 chr1:42093821 G/A cg06885757 chr1:42089581 HIVEP3 0.5 8.15 0.45 1.49e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs561341 1.000 rs501957 chr17:30314504 C/T cg12193833 chr17:30244370 NA -0.71 -6.63 -0.38 1.89e-10 Hip circumference adjusted for BMI; CESC cis rs1461503 0.868 rs11602682 chr11:122842315 A/T cg27398637 chr11:122830231 C11orf63 -0.53 -7.85 -0.43 1e-13 Menarche (age at onset); CESC cis rs6922893 1.000 rs6922893 chr6:71660111 A/G cg10766373 chr6:71666121 B3GAT2 -0.34 -5.47 -0.32 1.06e-7 Obesity-related traits; CESC cis rs11696501 0.688 rs2281211 chr20:44312858 C/T cg11783356 chr20:44313418 WFDC10B -0.34 -5.25 -0.31 3.05e-7 Brain structure; CESC cis rs10088262 0.629 rs12549683 chr8:124798276 G/C cg02993010 chr8:124780839 FAM91A1 -0.67 -8.55 -0.46 1.01e-15 Pancreatic cancer; CESC cis rs1023500 0.505 rs134878 chr22:42663874 A/G cg15557168 chr22:42548783 NA -0.41 -6.13 -0.35 3.17e-9 Schizophrenia; CESC cis rs7520050 0.966 rs6677007 chr1:46400590 A/G cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.66e-9 Red blood cell count;Reticulocyte count; CESC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg07157834 chr1:205819609 PM20D1 0.71 11.02 0.56 1.73e-23 Menarche (age at onset); CESC cis rs7107174 1.000 rs1399196 chr11:78071876 A/G cg02023728 chr11:77925099 USP35 0.37 5.31 0.31 2.3e-7 Testicular germ cell tumor; CESC cis rs9790314 0.846 rs1478568 chr3:161014276 C/T cg04691961 chr3:161091175 C3orf57 -0.38 -5.07 -0.3 7.52e-7 Morning vs. evening chronotype; CESC cis rs16866061 0.962 rs16825685 chr2:225434256 C/G cg12698349 chr2:225449008 CUL3 0.75 11.58 0.58 2.29e-25 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg22920501 chr2:26401640 FAM59B 0.91 10.38 0.54 2.08e-21 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20490900 chr1:1502606 SSU72 0.46 6.08 0.35 4.21e-9 Gut microbiome composition (summer); CESC cis rs11250464 0.736 rs5015512 chr10:1411923 T/C cg08668359 chr10:1443807 ADARB2 0.58 7.15 0.4 8.41e-12 Radiation response; CESC cis rs9908102 0.740 rs55674356 chr17:12905574 T/A cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs12474201 0.928 rs35825831 chr2:46932544 T/G cg06386533 chr2:46925753 SOCS5 0.91 12.61 0.61 7.38e-29 Height; CESC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg06074448 chr4:187884817 NA -0.37 -5.45 -0.32 1.13e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs6582630 0.537 rs1829579 chr12:38420555 A/G cg26384229 chr12:38710491 ALG10B 0.7 10.71 0.55 1.83e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs7623687 0.786 rs73088161 chr3:49465162 C/T cg07274523 chr3:49395745 GPX1 0.75 5.71 0.33 3e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CESC cis rs11249608 0.548 rs7733072 chr5:178456007 A/G cg01312482 chr5:178451176 ZNF879 -0.45 -6.36 -0.36 8.71e-10 Pubertal anthropometrics; CESC cis rs72792276 1.000 rs3805603 chr5:127451581 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.66 5.2 0.3 3.93e-7 Red cell distribution width; CESC cis rs1218582 0.661 rs4845695 chr1:154911798 A/G cg03351412 chr1:154909251 PMVK 0.52 6.39 0.37 7.52e-10 Prostate cancer; CESC cis rs62005083 1.000 rs62005154 chr14:74607008 G/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.76 5.5 0.32 8.8e-8 Mean corpuscular volume; CESC cis rs10979 1.000 rs9496681 chr6:143896964 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.07e-17 Hypospadias; CESC cis rs6714710 0.580 rs57804205 chr2:98454472 G/A cg26665480 chr2:98280029 ACTR1B 0.57 7.91 0.44 7.03e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs17376456 0.877 rs56373208 chr5:93491276 C/A cg25358565 chr5:93447407 FAM172A 1.17 10.96 0.56 2.63e-23 Diabetic retinopathy; CESC cis rs9894429 0.621 rs7502337 chr17:79588470 T/C cg21984481 chr17:79567631 NPLOC4 -0.35 -5.5 -0.32 9.13e-8 Eye color traits; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17757281 chr20:44604666 NA -0.41 -6.16 -0.35 2.76e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC cis rs854765 0.693 rs9907246 chr17:17770965 T/C cg16928487 chr17:17741425 SREBF1 0.6 10.79 0.55 9.76e-23 Total body bone mineral density; CESC cis rs10242455 0.571 rs117370443 chr7:98975258 T/C cg25640893 chr7:99214727 ZNF498 0.94 6.17 0.35 2.6e-9 Blood metabolite levels; CESC cis rs644799 0.932 rs523934 chr11:95641775 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.79 11.35 0.57 1.33e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3862260 0.509 rs10802124 chr1:120164252 G/A cg16322792 chr1:120165303 ZNF697 0.58 10.95 0.56 2.82e-23 Systemic lupus erythematosus; CESC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs4888262 0.564 rs8050850 chr16:74582597 C/A cg01733217 chr16:74700730 RFWD3 0.81 11.45 0.58 6.4e-25 Testicular germ cell tumor; CESC cis rs4253772 0.530 rs9615933 chr22:46677298 G/A cg24881330 chr22:46731750 TRMU 0.78 5.81 0.34 1.81e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.89e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg10691866 chr7:65817282 TPST1 0.33 5.24 0.31 3.31e-7 Aortic root size; CESC cis rs11083475 0.692 rs755690 chr19:39167360 A/G cg20002381 chr19:39279703 LGALS7B -0.23 -5.09 -0.3 6.67e-7 Heart rate; CESC cis rs1483121 0.609 rs34909049 chr11:48022512 C/T cg20307385 chr11:47447363 PSMC3 0.7 6.37 0.36 8.22e-10 Fasting blood glucose (BMI interaction);Fasting blood glucose; CESC cis rs8062405 0.723 rs12445744 chr16:28588395 A/C cg01378222 chr16:28622494 SULT1A1 0.3 5.06 0.3 7.89e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7927771 1.000 rs2290850 chr11:47807774 T/C cg20307385 chr11:47447363 PSMC3 -0.5 -6.07 -0.35 4.49e-9 Subjective well-being; CESC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg18876405 chr7:65276391 NA -0.56 -7.43 -0.42 1.46e-12 Aortic root size; CESC cis rs654950 0.783 rs639298 chr1:42001530 A/G cg06885757 chr1:42089581 HIVEP3 -0.48 -8.02 -0.44 3.38e-14 Airway imaging phenotypes; CESC cis rs9611565 0.649 rs6002480 chr22:42176917 A/T cg03806693 chr22:41940476 POLR3H -0.76 -9.12 -0.49 2.01e-17 Vitiligo; CESC cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg05347473 chr6:146136440 FBXO30 0.59 7.59 0.42 5.36e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs8070740 0.898 rs4239056 chr17:5324406 A/C cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.35 0.36 9.3e-10 Menopause (age at onset); CESC cis rs4957048 0.577 rs56294732 chr5:568144 T/C cg09021430 chr5:549028 NA -0.48 -6.57 -0.37 2.6e-10 Ulcerative colitis; CESC cis rs763121 0.853 rs2413546 chr22:39107001 G/A cg06544989 chr22:39130855 UNC84B 0.51 8.87 0.48 1.07e-16 Menopause (age at onset); CESC cis rs3106136 0.934 rs34145031 chr4:95167123 A/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.94 -0.39 3.02e-11 Capecitabine sensitivity; CESC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9837602 0.938 rs9828079 chr3:99806645 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 6.83 0.39 5.64e-11 Breast cancer; CESC trans rs10411161 0.702 rs7251689 chr19:52389117 A/T cg22319618 chr22:45562946 NUP50 -0.75 -7.56 -0.42 6.61e-13 Breast cancer; CESC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.4 -0.57 9.17e-25 Type 2 diabetes; CESC cis rs9815354 0.723 rs77572508 chr3:41938044 C/A cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs6582630 0.555 rs1969362 chr12:38514843 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.88 0.34 1.25e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg06212747 chr3:49208901 KLHDC8B 0.73 9.91 0.52 6.74e-20 Parkinson's disease; CESC cis rs4727027 0.933 rs12667123 chr7:148850621 G/A cg23158103 chr7:148848205 ZNF398 -0.42 -6.94 -0.39 3.1e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs34779708 0.931 rs67261877 chr10:35386340 T/A cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05970768 chr5:171682616 UBTD2 0.45 6.44 0.37 5.67e-10 Fibrinogen levels; CESC trans rs6818288 0.725 rs4286487 chr4:30077733 T/G cg12528397 chr3:62933670 NA 0.42 6.13 0.35 3.2e-9 Obesity-related traits; CESC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.54 7.99 0.44 4.17e-14 Bipolar disorder; CESC cis rs2599510 0.811 rs2754520 chr2:32810293 G/A cg02381751 chr2:32503542 YIPF4 0.43 5.3 0.31 2.45e-7 Interleukin-18 levels; CESC cis rs10141207 0.531 rs1547213 chr14:32678646 C/A cg23627301 chr14:32673368 NA 0.41 5.75 0.33 2.52e-8 Asthma; CESC cis rs7219021 0.674 rs4793990 chr17:46960760 G/A cg16584676 chr17:46985605 UBE2Z 0.63 7.71 0.43 2.52e-13 Schizophrenia or bipolar disorder; CESC cis rs7927771 0.864 rs3781627 chr11:47441472 T/A cg18512352 chr11:47633146 NA 0.45 6.31 0.36 1.19e-9 Subjective well-being; CESC cis rs1878931 0.517 rs17685105 chr16:3413749 C/T cg00484396 chr16:3507460 NAT15 0.34 5.09 0.3 6.64e-7 Body mass index (adult); CESC cis rs7580658 0.545 rs12477559 chr2:127951797 C/T cg10021288 chr2:128175891 PROC -0.32 -5.07 -0.3 7.48e-7 Protein C levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20615951 chr1:246730188 CNST;TFB2M -0.46 -6.21 -0.36 2.02e-9 Height; CESC cis rs412050 0.744 rs735244 chr22:22292099 C/T cg17089214 chr22:22089827 YPEL1 0.67 5.77 0.33 2.2e-8 Attention deficit hyperactivity disorder; CESC cis rs9913156 0.793 rs9436 chr17:4574751 T/A cg19197139 chr17:4613644 ARRB2 0.94 10.64 0.55 2.94e-22 Lymphocyte counts; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05312862 chr19:3699951 PIP5K1C -0.49 -6.27 -0.36 1.44e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg10862848 chr6:42927986 GNMT 0.3 7.7 0.43 2.78e-13 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7666738 0.830 rs1813251 chr4:98921170 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.32 0.31 2.17e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 1.000 rs6083805 chr20:25317356 T/C cg08601574 chr20:25228251 PYGB -0.39 -5.58 -0.32 5.94e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2979489 0.945 rs11988541 chr8:30334273 G/A cg26383811 chr8:30366931 RBPMS -0.84 -9.93 -0.52 5.8e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs892961 0.867 rs1079354 chr17:75415713 C/T cg05865280 chr17:75406074 SEPT9 0.58 11.17 0.57 5.43e-24 Airflow obstruction; CESC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg15445000 chr17:37608096 MED1 -0.4 -6.54 -0.37 3.14e-10 Glomerular filtration rate (creatinine); CESC cis rs10242455 0.571 rs41279866 chr7:99315276 C/T cg25640893 chr7:99214727 ZNF498 0.85 5.73 0.33 2.69e-8 Blood metabolite levels; CESC cis rs193541 0.632 rs10037044 chr5:122123299 A/G cg19412675 chr5:122181750 SNX24 -0.42 -5.04 -0.3 8.61e-7 Glucose homeostasis traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01806808 chr8:142011144 PTK2 0.67 7.36 0.41 2.36e-12 Gut microbiome composition (summer); CESC cis rs6502050 0.712 rs8077079 chr17:80059011 C/T cg23985595 chr17:80112537 CCDC57 0.39 5.9 0.34 1.13e-8 Life satisfaction; CESC cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg06027949 chr8:82754900 SNX16 -0.44 -5.23 -0.31 3.48e-7 Diastolic blood pressure; CESC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg25204440 chr1:209979598 IRF6 0.65 6.63 0.38 1.83e-10 Cleft lip with or without cleft palate; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09563240 chr3:47205630 SETD2 0.51 6.66 0.38 1.58e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs748404 0.697 rs524547 chr15:43551023 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.62 7.94 0.44 5.82e-14 Lung cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11642829 chr17:4607740 PELP1 0.48 6.77 0.38 8.28e-11 Gut microbiota (bacterial taxa); CESC cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg19539972 chr4:7069911 GRPEL1 0.78 9.87 0.52 9.02e-20 Monocyte percentage of white cells; CESC cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg17366294 chr4:99064904 C4orf37 0.5 7.58 0.42 5.75e-13 Colonoscopy-negative controls vs population controls; CESC cis rs477692 0.517 rs871026 chr10:131293145 A/G cg05714579 chr10:131428358 MGMT -0.42 -5.4 -0.31 1.46e-7 Response to temozolomide; CESC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.68 0.38 1.41e-10 Electroencephalogram traits; CESC cis rs6690583 0.623 rs61768853 chr1:85455707 T/C cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg23985595 chr17:80112537 CCDC57 0.41 6.42 0.37 6.41e-10 Life satisfaction; CESC cis rs6982240 0.514 rs10089212 chr8:142265380 T/A cg27411547 chr8:142287226 NA -0.52 -7.24 -0.41 5.01e-12 Tonsillectomy; CESC cis rs863345 0.504 rs2482966 chr1:158563321 T/A cg12129480 chr1:158549410 OR10X1 -0.3 -5.57 -0.32 6.31e-8 Pneumococcal bacteremia; CESC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg02564969 chr6:151773285 C6orf211;RMND1 -0.59 -7.7 -0.43 2.79e-13 Menarche (age at onset); CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg11965913 chr1:205819406 PM20D1 0.91 16.7 0.72 2.84e-43 Menarche (age at onset); CESC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg16743903 chr16:89593216 SPG7 -0.41 -5.37 -0.31 1.7e-7 Multiple myeloma (IgH translocation); CESC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg03352830 chr11:487213 PTDSS2 0.74 7.23 0.41 5.31e-12 Body mass index; CESC trans rs35110281 0.591 rs86138 chr21:44932398 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 6.44 0.37 5.69e-10 Mean corpuscular volume; CESC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg13114125 chr14:105738426 BRF1 -0.9 -11.13 -0.56 7.35e-24 Mean platelet volume;Platelet distribution width; CESC cis rs317689 0.918 rs610192 chr12:69739941 T/C cg20891283 chr12:69753455 YEATS4 0.61 6.91 0.39 3.68e-11 Response to diuretic therapy; CESC cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg22862634 chr11:62369728 EML3;MTA2 0.59 8.19 0.45 1.08e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6963495 0.745 rs68153235 chr7:105184832 A/C cg02135003 chr7:105160482 PUS7 -0.43 -5.94 -0.34 9.16e-9 Bipolar disorder (body mass index interaction); CESC cis rs7904368 0.754 rs11254231 chr10:16870246 A/G cg23933602 chr10:16859644 RSU1 0.57 5.09 0.3 6.65e-7 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs10883723 0.668 rs12414479 chr10:104420902 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.59 6.93 0.39 3.27e-11 Allergic disease (asthma, hay fever or eczema); CESC cis rs6987853 0.666 rs2923403 chr8:42447748 G/T cg09913449 chr8:42400586 C8orf40 0.44 7.41 0.41 1.69e-12 Mean corpuscular hemoglobin concentration; CESC cis rs9303401 0.614 rs56284918 chr17:57178838 A/G cg25039879 chr17:56429692 SUPT4H1 0.5 5.29 0.31 2.58e-7 Cognitive test performance; CESC cis rs13191362 0.507 rs2846535 chr6:163034019 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.54 -6.89 -0.39 3.97e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg13918804 chr1:2043761 PRKCZ 0.27 5.07 0.3 7.47e-7 Height; CESC cis rs7659604 0.540 rs10004284 chr4:122699222 A/T cg19748678 chr4:122722346 EXOSC9 -0.44 -5.59 -0.33 5.5e-8 Type 2 diabetes; CESC cis rs2228479 0.850 rs2238532 chr16:89863672 T/C cg00800038 chr16:89945340 TCF25 -0.88 -7.23 -0.41 5.07e-12 Skin colour saturation; CESC cis rs977987 0.581 rs8056141 chr16:75497162 A/T cg03315344 chr16:75512273 CHST6 0.48 6.72 0.38 1.12e-10 Dupuytren's disease; CESC cis rs16910800 0.731 rs35725172 chr11:23185968 G/A cg20040320 chr11:23191996 NA -0.68 -6.61 -0.38 2.09e-10 Cancer; CESC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg26516362 chr5:178986906 RUFY1 0.42 6.34 0.36 9.74e-10 Lung cancer; CESC cis rs7551222 0.749 rs11240761 chr1:204566700 C/A cg20240347 chr1:204465584 NA -0.27 -5.61 -0.33 5.11e-8 Schizophrenia; CESC cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg15605315 chr1:45957053 TESK2 0.5 6.63 0.38 1.83e-10 High light scatter reticulocyte count; CESC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg02807482 chr3:125708958 NA -0.41 -5.58 -0.32 6.02e-8 Blood pressure (smoking interaction); CESC cis rs9905704 1.000 rs9905704 chr17:56632543 G/T cg12560992 chr17:57184187 TRIM37 -0.61 -7.02 -0.4 1.8e-11 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.75 0.47 2.6e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7100689 0.784 rs10736341 chr10:82061206 C/G cg00277334 chr10:82204260 NA -0.58 -7.31 -0.41 3.1e-12 Post bronchodilator FEV1; CESC cis rs1050631 0.592 rs1785930 chr18:33723718 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.53 7.16 0.4 7.87e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs2625529 0.818 rs16956241 chr15:72111688 G/T cg16672083 chr15:72433130 SENP8 -0.43 -5.32 -0.31 2.26e-7 Red blood cell count; CESC cis rs854765 0.663 rs3744115 chr17:17749822 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.4 -5.1 -0.3 6.59e-7 Total body bone mineral density; CESC cis rs17253792 0.822 rs77599953 chr14:56058905 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs11785400 1.000 rs4736368 chr8:143748528 G/C cg10596483 chr8:143751796 JRK 0.43 5.63 0.33 4.59e-8 Schizophrenia; CESC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg18876405 chr7:65276391 NA -0.55 -7.65 -0.43 3.65e-13 Aortic root size; CESC cis rs6088580 0.634 rs6059890 chr20:33101653 G/C cg24642439 chr20:33292090 TP53INP2 0.5 6.54 0.37 3.21e-10 Glomerular filtration rate (creatinine); CESC cis rs2243480 1.000 rs9769882 chr7:65642925 T/C cg12463550 chr7:65579703 CRCP -0.73 -5.66 -0.33 4.03e-8 Diabetic kidney disease; CESC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg17376030 chr22:41985996 PMM1 -0.8 -8.34 -0.46 3.99e-15 Vitiligo; CESC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg23281280 chr6:28129359 ZNF389 0.6 8.04 0.44 2.95e-14 Depression; CESC cis rs561341 1.000 rs576985 chr17:30323323 C/T cg19193384 chr17:30244184 NA -0.7 -6.58 -0.37 2.49e-10 Hip circumference adjusted for BMI; CESC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg04414720 chr1:150670196 GOLPH3L 0.58 7.57 0.42 6.3e-13 Melanoma; CESC cis rs4803468 0.967 rs13345590 chr19:41886455 T/G cg14132834 chr19:41945861 ATP5SL -0.61 -7.79 -0.43 1.53e-13 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11759937 chr19:47729458 BBC3 0.59 6.42 0.37 6.1e-10 Gut microbiome composition (summer); CESC trans rs1814175 0.618 rs1851843 chr11:50021846 T/C cg03929089 chr4:120376271 NA -0.91 -14.8 -0.67 1.58e-36 Height; CESC cis rs637571 0.544 rs12361552 chr11:65701204 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.56 -6.88 -0.39 4.38e-11 Eosinophil percentage of white cells; CESC cis rs6087990 0.735 rs4911261 chr20:31391360 A/G cg13636640 chr20:31349939 DNMT3B 0.8 12.86 0.62 9.44e-30 Ulcerative colitis; CESC trans rs330048 0.561 rs330088 chr8:9149746 T/C cg06636001 chr8:8085503 FLJ10661 0.49 6.33 0.36 1.01e-9 Systemic lupus erythematosus; CESC cis rs1801251 1.000 rs4517962 chr2:233578337 T/C cg08000102 chr2:233561755 GIGYF2 0.66 9.02 0.48 3.87e-17 Coronary artery disease; CESC cis rs9457247 1.000 rs376551 chr6:167384923 G/A cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 5.12e-16 Crohn's disease; CESC cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg02297831 chr4:17616191 MED28 0.53 6.72 0.38 1.12e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7662987 0.517 rs4235436 chr4:100039620 G/A cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC cis rs4718428 0.705 rs68168107 chr7:66255238 G/A cg12165864 chr7:66369176 NA -0.66 -7.44 -0.42 1.41e-12 Corneal structure; CESC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.97 0.52 4.33e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1059312 0.966 rs12370194 chr12:129277250 A/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -9.86 -0.52 9.39e-20 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20011974 chr14:75469661 EIF2B2 -0.61 -6.91 -0.39 3.66e-11 Gut microbiome composition (summer); CESC cis rs3617 0.625 rs11922961 chr3:52868610 T/C cg11645453 chr3:52864694 ITIH4 -0.26 -5.28 -0.31 2.65e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC trans rs208520 0.754 rs7753158 chr6:66875633 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.33 -0.57 1.55e-24 Exhaled nitric oxide output; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03489495 chr6:33588875 ITPR3 -0.42 -6.04 -0.35 5.11e-9 Gambling; CESC cis rs2070433 0.749 rs718496 chr21:47904585 A/C cg12379764 chr21:47803548 PCNT 0.46 5.58 0.32 6.08e-8 Lymphocyte counts; CESC cis rs1348850 0.846 rs4893962 chr2:178421106 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.69 9.44 0.5 2.04e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10870270 1.000 rs4880250 chr10:133773919 G/A cg26149184 chr10:133730230 NA 0.37 5.08 0.3 7.3e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08204369 chr17:73150733 HN1 0.52 7.11 0.4 1.09e-11 Gut microbiota (bacterial taxa); CESC cis rs9457247 0.515 rs1951459 chr6:167402536 G/A cg25258033 chr6:167368657 RNASET2 -0.37 -5.41 -0.32 1.42e-7 Crohn's disease; CESC cis rs3892630 0.588 rs7260037 chr19:33242701 G/A cg22980127 chr19:33182716 NUDT19 1.13 14.4 0.66 4.03e-35 Red blood cell traits; CESC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg04287289 chr16:89883240 FANCA 0.94 16.82 0.72 1.1e-43 Vitiligo; CESC cis rs71277158 0.624 rs16854848 chr3:169822201 T/C cg04067573 chr3:169899625 PHC3 0.68 6.93 0.39 3.24e-11 Prostate cancer; CESC cis rs12476592 0.602 rs11125978 chr2:63809602 C/T cg17519650 chr2:63277830 OTX1 -0.48 -5.39 -0.31 1.52e-7 Childhood ear infection; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08204369 chr17:73150733 HN1 0.5 6.97 0.39 2.48e-11 Systemic lupus erythematosus; CESC cis rs1348850 0.914 rs7565022 chr2:178320222 A/T cg22681709 chr2:178499509 PDE11A -0.4 -5.98 -0.34 7.17e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg07936489 chr17:37558343 FBXL20 -0.79 -11.09 -0.56 9.87e-24 Glomerular filtration rate (creatinine); CESC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg02038168 chr22:39784481 NA -0.64 -8.08 -0.44 2.23e-14 Intelligence (multi-trait analysis); CESC cis rs7561273 0.565 rs6545275 chr2:24331860 A/G cg20701182 chr2:24300061 SF3B14 0.51 6.52 0.37 3.55e-10 Quantitative traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02929209 chr4:53588595 NA -0.47 -6.42 -0.37 6.31e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2635047 0.934 rs11663321 chr18:44622704 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.94 0.39 3.07e-11 Educational attainment; CESC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg22029157 chr1:209979665 IRF6 0.66 7.33 0.41 2.8e-12 Cleft lip with or without cleft palate; CESC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg05872129 chr22:39784769 NA -0.84 -11.23 -0.57 3.43e-24 Intelligence (multi-trait analysis); CESC trans rs875971 0.964 rs6978721 chr7:65883204 A/G cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.77e-9 Aortic root size; CESC cis rs7793919 0.764 rs6944865 chr7:4766383 A/T cg09789173 chr7:4769017 FOXK1 0.79 12.54 0.61 1.2e-28 Mosquito bite size; CESC cis rs17376456 0.877 rs10078194 chr5:93364310 A/C cg21475434 chr5:93447410 FAM172A 0.78 6.96 0.39 2.72e-11 Diabetic retinopathy; CESC cis rs13394619 0.775 rs10200851 chr2:11722082 C/T cg07314298 chr2:11723111 GREB1 -0.37 -5.2 -0.3 3.9e-7 Endometriosis; CESC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg02428538 chr16:24856791 SLC5A11 -0.58 -6.03 -0.35 5.42e-9 Intelligence (multi-trait analysis); CESC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg13395646 chr4:1353034 KIAA1530 -0.4 -5.35 -0.31 1.88e-7 Longevity; CESC cis rs568617 1.000 rs641018 chr11:65655393 G/C cg04055107 chr11:65626734 MUS81;CFL1 0.69 7.43 0.42 1.47e-12 Crohn's disease; CESC cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs1401999 1.000 rs7620350 chr3:183710053 A/T cg01324343 chr3:183735012 ABCC5 0.64 13.58 0.64 3.13e-32 Anterior chamber depth; CESC cis rs2820292 0.678 rs4309038 chr1:201884647 C/G cg11586189 chr1:201857591 SHISA4 -0.35 -5.84 -0.34 1.53e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs3820068 0.705 rs4646072 chr1:15827711 G/A cg18192808 chr1:15853278 DNAJC16 0.47 5.56 0.32 6.42e-8 Systolic blood pressure; CESC cis rs12541635 0.966 rs12680670 chr8:107006811 T/G cg10147462 chr8:107024639 NA 0.42 5.96 0.34 7.89e-9 Age of smoking initiation; CESC cis rs60154123 0.505 rs1319435 chr1:210047618 C/T cg22029157 chr1:209979665 IRF6 -0.71 -7.2 -0.4 6.19e-12 Coronary artery disease; CESC cis rs79349575 0.783 rs58591767 chr17:47026076 G/A cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06529459 chr11:67397595 NUDT8 -0.47 -6.13 -0.35 3.09e-9 Fibrinogen levels; CESC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg05863683 chr7:1912471 MAD1L1 0.43 6.37 0.36 8.36e-10 Bipolar disorder and schizophrenia; CESC cis rs6754311 0.608 rs3739020 chr2:136602491 T/G cg07169764 chr2:136633963 MCM6 0.65 8.13 0.45 1.62e-14 Mosquito bite size; CESC cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6429082 0.749 rs3819974 chr1:235601958 G/T cg26050004 chr1:235667680 B3GALNT2 -0.61 -7.76 -0.43 1.85e-13 Adiposity; CESC cis rs1707322 0.717 rs12023439 chr1:46104636 C/T cg05343316 chr1:45956843 TESK2 0.51 6.35 0.36 9.44e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7044106 0.791 rs747819 chr9:123488441 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.58 0.32 6.06e-8 Hip circumference adjusted for BMI; CESC cis rs2066819 1.000 rs11575234 chr12:56744276 C/G cg26714650 chr12:56694279 CS -1.22 -14.58 -0.67 9.61e-36 Psoriasis vulgaris; CESC cis rs11577318 0.853 rs11247913 chr1:26648551 G/C cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.47 -0.37 4.67e-10 Granulocyte percentage of myeloid white cells; CESC cis rs35955747 0.902 rs739427 chr22:31659101 C/G cg25791279 chr22:32026902 PISD 0.48 5.71 0.33 3.06e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg12463550 chr7:65579703 CRCP 0.51 6.41 0.37 6.58e-10 Aortic root size; CESC cis rs61931739 0.500 rs6416261 chr12:34540377 T/C cg06521331 chr12:34319734 NA -0.36 -5.03 -0.3 9.01e-7 Morning vs. evening chronotype; CESC cis rs6912958 0.559 rs446851 chr6:88043640 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.74 11.07 0.56 1.2e-23 Monocyte percentage of white cells; CESC cis rs897984 0.542 rs7199949 chr16:31096164 G/C cg00531865 chr16:30841666 NA -0.39 -5.42 -0.32 1.33e-7 Dementia with Lewy bodies; CESC cis rs36051895 0.632 rs1328919 chr9:5166548 C/T cg02405213 chr9:5042618 JAK2 -0.46 -5.36 -0.31 1.77e-7 Pediatric autoimmune diseases; CESC cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs10751667 0.600 rs4076915 chr11:1012464 C/G cg20946044 chr11:1010712 AP2A2 -0.48 -6.33 -0.36 1.04e-9 Alzheimer's disease (late onset); CESC cis rs12477438 0.520 rs13009147 chr2:99803998 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 14.96 0.68 4.16e-37 Chronic sinus infection; CESC cis rs1670533 1.000 rs629261 chr4:1086763 A/C cg27284194 chr4:1044797 NA 0.48 6.17 0.35 2.6e-9 Recombination rate (females); CESC cis rs35995292 0.500 rs7776996 chr7:38919762 G/C cg19327137 chr7:38886074 VPS41 0.66 10.86 0.55 5.69e-23 Subjective well-being (multi-trait analysis); CESC cis rs3820068 0.581 rs16851855 chr1:15930869 G/A cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs6598955 0.640 rs6667826 chr1:26531408 T/C cg04990556 chr1:26633338 UBXN11 -0.75 -10.53 -0.54 6.97e-22 Obesity-related traits; CESC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.3 0.36 1.21e-9 Menopause (age at onset); CESC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg02018176 chr4:1364513 KIAA1530 0.6 7.62 0.42 4.61e-13 Longevity; CESC cis rs941408 0.515 rs1640262 chr19:2779134 C/T cg00079169 chr19:2811669 THOP1 -0.38 -5.17 -0.3 4.61e-7 Total cholesterol levels; CESC cis rs9790314 0.905 rs6774276 chr3:160941318 C/T cg03342759 chr3:160939853 NMD3 -0.48 -6.33 -0.36 1.04e-9 Morning vs. evening chronotype; CESC cis rs6964587 0.934 rs6973792 chr7:91749798 C/A cg17063962 chr7:91808500 NA 0.55 7.42 0.41 1.61e-12 Breast cancer; CESC cis rs9463078 0.665 rs227849 chr6:44698708 C/T cg25276700 chr6:44698697 NA 0.34 5.14 0.3 5.36e-7 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs854765 0.583 rs9908832 chr17:17871068 C/T cg04398451 chr17:18023971 MYO15A -0.73 -10.6 -0.55 4.17e-22 Total body bone mineral density; CESC cis rs208520 0.661 rs207079 chr6:66770462 C/T cg07460842 chr6:66804631 NA -1.0 -12.95 -0.62 4.78e-30 Exhaled nitric oxide output; CESC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg27170947 chr2:26402098 FAM59B -0.61 -7.16 -0.4 7.86e-12 Gut microbiome composition (summer); CESC cis rs6088580 0.634 rs6059868 chr20:33079460 A/G cg06115741 chr20:33292138 TP53INP2 0.45 5.75 0.33 2.5e-8 Glomerular filtration rate (creatinine); CESC cis rs6088590 0.561 rs764597 chr20:33161225 C/T cg08999081 chr20:33150536 PIGU 0.67 11.74 0.59 6.51e-26 Coronary artery disease; CESC cis rs9611565 0.765 rs202663 chr22:41812819 T/C cg06634786 chr22:41940651 POLR3H 0.7 7.4 0.41 1.78e-12 Vitiligo; CESC cis rs11190604 1.000 rs12358187 chr10:102284449 C/G cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs62229266 0.618 rs11088334 chr21:37466829 A/T cg12218747 chr21:37451666 NA -0.47 -6.46 -0.37 5.1e-10 Mitral valve prolapse; CESC cis rs6546550 0.901 rs897119 chr2:70160658 T/C cg02498382 chr2:70120550 SNRNP27 -0.4 -6.91 -0.39 3.62e-11 Prevalent atrial fibrillation; CESC cis rs3767633 0.925 rs6427639 chr1:161866372 C/A cg09175582 chr1:161736000 ATF6 0.85 6.91 0.39 3.53e-11 IgG glycosylation; CESC cis rs6866344 0.697 rs17184344 chr5:178129281 A/G cg03877680 chr5:178157825 ZNF354A 0.77 9.01 0.48 4.15e-17 Neutrophil percentage of white cells; CESC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg06221963 chr1:154839813 KCNN3 -0.66 -11.48 -0.58 4.9e-25 Prostate cancer; CESC cis rs10927875 0.929 rs4661674 chr1:16296039 A/G cg21385522 chr1:16154831 NA -0.77 -9.6 -0.51 6.35e-19 Dilated cardiomyopathy; CESC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg22974920 chr21:40686053 BRWD1 -0.42 -5.09 -0.3 6.67e-7 Cognitive function; CESC trans rs1908814 0.504 rs7830734 chr8:11795639 C/T cg15556689 chr8:8085844 FLJ10661 0.53 6.46 0.37 4.89e-10 Neuroticism; CESC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg24829409 chr8:58192753 C8orf71 -0.62 -8.39 -0.46 3.01e-15 Developmental language disorder (linguistic errors); CESC cis rs6570726 0.935 rs384453 chr6:145815145 G/C cg05347473 chr6:146136440 FBXO30 0.5 6.71 0.38 1.15e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.34 -0.31 2.02e-7 Lung cancer; CESC cis rs4853012 0.941 rs7571083 chr2:74342260 C/G cg05776053 chr2:74358815 NA 0.42 5.23 0.31 3.47e-7 Gestational age at birth (maternal effect); CESC cis rs68170813 0.559 rs78267892 chr7:106823734 C/T cg02696742 chr7:106810147 HBP1 -0.55 -5.32 -0.31 2.24e-7 Coronary artery disease; CESC cis rs1728785 1.000 rs12925177 chr16:68569645 A/G cg02972257 chr16:68554789 NA 0.53 6.19 0.36 2.33e-9 Ulcerative colitis; CESC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg11301795 chr4:187892539 NA -0.75 -12.33 -0.6 6.74e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs728616 0.867 rs61860417 chr10:81734727 C/T cg05935833 chr10:81318306 SFTPA2 -0.53 -5.37 -0.31 1.72e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs1707322 1.000 rs10890350 chr1:46262378 G/A cg03146154 chr1:46216737 IPP 0.71 9.81 0.52 1.43e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1707322 0.686 rs61784833 chr1:46233772 T/C cg03146154 chr1:46216737 IPP 0.81 11.48 0.58 4.89e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg26597838 chr10:835615 NA 0.95 10.4 0.54 1.83e-21 Eosinophil percentage of granulocytes; CESC cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg03060546 chr3:49711283 APEH 0.45 5.62 0.33 4.84e-8 Parkinson's disease; CESC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg15145296 chr3:125709740 NA -0.52 -5.47 -0.32 1.06e-7 Blood pressure (smoking interaction); CESC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg24060327 chr5:131705240 SLC22A5 -0.4 -5.12 -0.3 5.81e-7 Breast cancer; CESC cis rs9549260 0.755 rs58919811 chr13:41226485 A/C cg21288729 chr13:41239152 FOXO1 0.65 8.5 0.46 1.4e-15 Red blood cell count; CESC cis rs7927771 1.000 rs34128973 chr11:47851376 C/T cg05585544 chr11:47624801 NA -0.5 -7.69 -0.43 2.81e-13 Subjective well-being; CESC cis rs863345 0.604 rs1157524 chr1:158457298 T/C cg12129480 chr1:158549410 OR10X1 -0.36 -7.15 -0.4 8.67e-12 Pneumococcal bacteremia; CESC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg17724175 chr1:150552817 MCL1 0.43 7.13 0.4 9.75e-12 Urate levels; CESC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg09417038 chr21:47716443 C21orf57 -0.43 -6.01 -0.35 6.09e-9 Testicular germ cell tumor; CESC cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg05535760 chr7:792225 HEATR2 -0.8 -8.27 -0.45 6.55e-15 Cerebrospinal P-tau181p levels; CESC cis rs4692589 1.000 rs4692783 chr4:170935407 G/A cg19918862 chr4:170955249 NA 0.35 5.53 0.32 7.58e-8 Anxiety disorder; CESC cis rs2404602 0.684 rs1603860 chr15:76849591 A/T cg23625390 chr15:77176239 SCAPER -0.44 -6.13 -0.35 3.14e-9 Blood metabolite levels; CESC cis rs4969178 0.832 rs4969185 chr17:76398157 G/C cg20026190 chr17:76395443 PGS1 0.49 7.79 0.43 1.51e-13 HDL cholesterol levels; CESC cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.42 5.85 0.34 1.45e-8 Schizophrenia; CESC cis rs7116495 1.000 rs6592453 chr11:71683231 C/G cg10381502 chr11:71823885 C11orf51 -0.66 -5.43 -0.32 1.3e-7 Severe influenza A (H1N1) infection; CESC cis rs3015497 0.789 rs3015502 chr14:51108427 T/C cg09863266 chr14:51125203 SAV1 -0.35 -5.4 -0.31 1.48e-7 Mean platelet volume; CESC cis rs4820539 0.611 rs28451783 chr22:23488569 G/T cg14186256 chr22:23484241 RTDR1 0.7 10.34 0.54 2.79e-21 Bone mineral density; CESC cis rs2404602 0.575 rs11072611 chr15:76947983 A/G cg00316803 chr15:76480434 C15orf27 -0.38 -5.33 -0.31 2.13e-7 Blood metabolite levels; CESC cis rs2299587 0.698 rs2283113 chr8:17880243 C/A cg08627089 chr8:17753878 FGL1 -0.37 -5.21 -0.3 3.8e-7 Economic and political preferences; CESC cis rs7851660 0.967 rs10046805 chr9:100613956 G/A cg13688889 chr9:100608707 NA -0.68 -10.54 -0.54 6.55e-22 Strep throat; CESC cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg03146154 chr1:46216737 IPP -0.44 -5.58 -0.32 5.84e-8 High light scatter reticulocyte count; CESC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg06873352 chr17:61820015 STRADA 0.73 12.89 0.62 7.87e-30 Prudent dietary pattern; CESC cis rs2204008 0.619 rs11178987 chr12:38201258 C/T cg26384229 chr12:38710491 ALG10B -0.43 -5.92 -0.34 9.92e-9 Bladder cancer; CESC cis rs7178909 0.902 rs2043881 chr15:90439960 G/A cg19708238 chr15:90437601 AP3S2 0.44 6.28 0.36 1.38e-9 Common traits (Other); CESC cis rs7193541 0.662 rs8058133 chr16:74657485 A/T cg05580060 chr16:74700937 RFWD3 -0.42 -5.36 -0.31 1.82e-7 Multiple myeloma; CESC cis rs9811920 0.535 rs792835 chr3:99476295 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.33 -5.42 -0.32 1.37e-7 Axial length; CESC cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg20476274 chr7:133979776 SLC35B4 0.62 8.99 0.48 4.89e-17 Mean platelet volume; CESC cis rs10979 1.000 rs13197332 chr6:143888095 T/A cg25407410 chr6:143891975 LOC285740 -0.63 -9.51 -0.5 1.24e-18 Hypospadias; CESC trans rs6499129 0.571 rs6499118 chr16:67265360 C/A cg17013778 chr10:135130084 NA -0.68 -6.02 -0.35 5.74e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs61931739 0.517 rs10772139 chr12:34186178 A/T cg19457237 chr12:34500585 NA -0.39 -5.39 -0.31 1.53e-7 Morning vs. evening chronotype; CESC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg00166722 chr3:10149974 C3orf24 -0.45 -5.57 -0.32 6.4e-8 Alzheimer's disease; CESC cis rs36093924 0.646 rs5996094 chr22:42347060 A/G cg15557168 chr22:42548783 NA 0.35 5.11 0.3 6.28e-7 Intelligence; CESC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg24110177 chr3:50126178 RBM5 -0.54 -7.41 -0.41 1.72e-12 Intelligence (multi-trait analysis); CESC cis rs9487051 0.676 rs2222392 chr6:109602303 T/C cg12927641 chr6:109611667 NA -0.37 -5.52 -0.32 8.25e-8 Reticulocyte fraction of red cells; CESC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg06873352 chr17:61820015 STRADA 0.72 12.95 0.62 4.81e-30 Prudent dietary pattern; CESC cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs858239 0.600 rs4628176 chr7:23142566 C/T cg23682824 chr7:23144976 KLHL7 0.5 6.73 0.38 1.02e-10 Cerebrospinal fluid biomarker levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00905354 chr6:170059414 WDR27 -0.52 -6.05 -0.35 5e-9 Gut microbiome composition (summer); CESC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.61 0.33 5.13e-8 Intelligence (multi-trait analysis); CESC cis rs7772486 0.875 rs2748483 chr6:146335560 A/T cg05347473 chr6:146136440 FBXO30 -0.51 -6.46 -0.37 5.08e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18146300 chr17:17184632 COPS3 0.47 6.55 0.37 2.91e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9640161 0.783 rs1132261 chr7:150059987 G/A cg10018233 chr7:150070692 REPIN1 0.37 5.68 0.33 3.62e-8 Blood protein levels;Circulating chemerin levels; CESC trans rs61931739 0.534 rs1486886 chr12:34043619 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.22 0.41 5.44e-12 Morning vs. evening chronotype; CESC cis rs2354432 0.556 rs4295925 chr1:146857335 T/C cg25205988 chr1:146714368 CHD1L 1.03 9.11 0.49 2.04e-17 Mitochondrial DNA levels; CESC cis rs2050392 0.624 rs303436 chr10:30731893 G/T cg18806716 chr10:30721971 MAP3K8 -0.61 -9.12 -0.49 1.93e-17 Inflammatory bowel disease; CESC cis rs5750830 0.594 rs9611165 chr22:39775250 A/G cg05872129 chr22:39784769 NA -0.75 -10.71 -0.55 1.76e-22 Intelligence (multi-trait analysis); CESC cis rs13720 1.000 rs13720 chr20:57570568 G/A cg23907860 chr20:57583709 CTSZ -0.47 -5.66 -0.33 3.97e-8 Platelet distribution width; CESC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg06873352 chr17:61820015 STRADA 0.73 12.98 0.62 3.9e-30 Prudent dietary pattern; CESC cis rs1879734 0.636 rs12043690 chr1:54175629 T/C cg23596471 chr1:54105337 GLIS1 0.32 5.17 0.3 4.7e-7 Mitral valve prolapse; CESC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs1348850 0.554 rs11679519 chr2:178432110 C/T cg23306229 chr2:178417860 TTC30B 0.83 9.16 0.49 1.45e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs79149102 0.649 rs8039046 chr15:75096352 A/G cg09165964 chr15:75287851 SCAMP5 -0.71 -5.26 -0.31 2.97e-7 Lung cancer; CESC cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs73072330 0.643 rs56298666 chr3:47667218 A/G cg09665691 chr3:47563885 NA 0.93 5.68 0.33 3.57e-8 Stem cell growth factor beta levels; CESC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg26338869 chr17:61819248 STRADA 0.73 9.68 0.51 3.66e-19 Prudent dietary pattern; CESC cis rs763014 0.898 rs1045277 chr16:633125 T/C cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05101135 chr3:179367500 NA -0.36 -6.08 -0.35 4.13e-9 Gambling; CESC cis rs8014204 0.806 rs11159104 chr14:75293374 A/G cg08847533 chr14:75593920 NEK9 0.46 5.88 0.34 1.23e-8 Caffeine consumption; CESC cis rs17826219 0.561 rs562840 chr17:28949390 G/T cg14008862 chr17:28927542 LRRC37B2 0.63 6.04 0.35 5.13e-9 Body mass index; CESC cis rs798554 0.660 rs798480 chr7:2805597 G/T cg13628971 chr7:2884303 GNA12 0.4 5.13 0.3 5.47e-7 Height; CESC cis rs3820068 0.581 rs72645861 chr1:15920314 A/G cg16988262 chr1:15930761 NA 0.35 5.63 0.33 4.6e-8 Systolic blood pressure; CESC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg02725872 chr8:58115012 NA -0.34 -5.31 -0.31 2.34e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20375947 chr15:25454579 SNORD115-15;SNORD115-21;SNORD115-22 -0.42 -6.21 -0.36 2.09e-9 Gut microbiome composition (summer); CESC cis rs8072100 0.837 rs62074055 chr17:45771933 G/C cg08085267 chr17:45401833 C17orf57 -0.39 -5.12 -0.3 6.01e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.51 0.46 1.33e-15 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.66 0.64 1.57e-32 Prudent dietary pattern; CESC cis rs2288912 0.838 rs7251503 chr19:45455715 C/G cg09555818 chr19:45449301 APOC2 0.41 6.54 0.37 3.08e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2273669 0.667 rs78550764 chr6:109312239 C/T cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs9790314 0.875 rs336582 chr3:161082659 C/T cg03342759 chr3:160939853 NMD3 -0.41 -5.4 -0.31 1.5e-7 Morning vs. evening chronotype; CESC cis rs924607 1.000 rs924607 chr5:610093 C/T cg09021430 chr5:549028 NA 0.38 6.79 0.38 7.46e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10668512 chr15:42565522 GANC;TMEM87A -0.47 -6.95 -0.39 2.75e-11 Gambling; CESC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs7918232 0.830 rs10764672 chr10:27392541 A/C cg14442939 chr10:27389572 ANKRD26 -0.66 -7.09 -0.4 1.21e-11 Breast cancer; CESC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.68 -0.33 3.5e-8 Total body bone mineral density; CESC cis rs7116495 1.000 rs1573502 chr11:71747428 C/T cg26138937 chr11:71823887 C11orf51 -0.82 -6.68 -0.38 1.39e-10 Severe influenza A (H1N1) infection; CESC cis rs7927592 0.673 rs2510392 chr11:68394457 C/G cg20283391 chr11:68216788 NA -0.42 -5.09 -0.3 6.86e-7 Total body bone mineral density; CESC cis rs68170813 0.559 rs3801958 chr7:106961139 C/T cg02696742 chr7:106810147 HBP1 -0.56 -5.33 -0.31 2.08e-7 Coronary artery disease; CESC cis rs59918340 0.692 rs6983780 chr8:142231944 G/A cg23750338 chr8:142222470 SLC45A4 0.64 9.86 0.52 9.5e-20 Immature fraction of reticulocytes; CESC cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg26516362 chr5:178986906 RUFY1 0.37 5.48 0.32 9.9e-8 Lung cancer; CESC cis rs72634258 0.945 rs34124834 chr1:8028930 T/G cg00042356 chr1:8021962 PARK7 0.94 8.47 0.46 1.74e-15 Inflammatory bowel disease; CESC cis rs67311347 1.000 rs6795475 chr3:40489281 A/G cg24209194 chr3:40518798 ZNF619 0.46 5.9 0.34 1.12e-8 Renal cell carcinoma; CESC cis rs10818894 0.571 rs4838068 chr9:126316354 G/A cg16191174 chr9:126692580 DENND1A 0.5 5.68 0.33 3.59e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); CESC cis rs2243480 1.000 rs35542501 chr7:65431215 T/C cg18252515 chr7:66147081 NA -1.06 -10.21 -0.53 7.51e-21 Diabetic kidney disease; CESC cis rs963731 0.737 rs79756054 chr2:39338998 A/G cg04010122 chr2:39346883 SOS1 0.68 5.53 0.32 7.68e-8 Corticobasal degeneration; CESC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg00149659 chr3:10157352 C3orf10 0.76 9.49 0.5 1.4e-18 Alzheimer's disease; CESC cis rs9457247 0.765 rs9457256 chr6:167436461 T/C cg07741184 chr6:167504864 NA 0.35 6.29 0.36 1.31e-9 Crohn's disease; CESC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg17724175 chr1:150552817 MCL1 0.4 6.08 0.35 4.25e-9 Melanoma; CESC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs7246760 0.867 rs55914342 chr19:9824447 A/T cg02900749 chr2:68251473 NA -0.81 -7.26 -0.41 4.4e-12 Pursuit maintenance gain; CESC cis rs3892630 0.588 rs1976501 chr19:33208155 C/T cg22980127 chr19:33182716 NUDT19 1.1 12.78 0.62 1.91e-29 Red blood cell traits; CESC cis rs6460942 0.505 rs62448708 chr7:12328450 G/A cg20607287 chr7:12443886 VWDE -0.45 -5.29 -0.31 2.52e-7 Coronary artery disease; CESC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg27170947 chr2:26402098 FAM59B -0.7 -8.52 -0.46 1.24e-15 Gut microbiome composition (summer); CESC cis rs854765 0.583 rs4257260 chr17:17857003 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg07507251 chr3:52567010 NT5DC2 0.42 7.33 0.41 2.77e-12 Bipolar disorder; CESC cis rs6088590 0.965 rs6058108 chr20:33288655 A/G cg06115741 chr20:33292138 TP53INP2 0.52 6.42 0.37 6.3e-10 Coronary artery disease; CESC cis rs6582630 0.638 rs11182428 chr12:38526387 T/C cg26384229 chr12:38710491 ALG10B -0.42 -5.59 -0.32 5.66e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg05368731 chr17:41323189 NBR1 0.54 7.58 0.42 5.7e-13 Menopause (age at onset); CESC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.33e-10 Skin colour saturation; CESC cis rs765787 0.530 rs11639403 chr15:45538350 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs8099014 0.906 rs4940692 chr18:56099715 A/G cg19312305 chr18:56117016 MIR122 -0.3 -5.72 -0.33 2.82e-8 Platelet count; CESC cis rs3820068 0.705 rs4645992 chr1:15849742 G/T cg18192808 chr1:15853278 DNAJC16 0.46 5.2 0.3 3.99e-7 Systolic blood pressure; CESC cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs644799 0.710 rs564480 chr11:95561741 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.76 10.63 0.55 3.37e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1707322 0.686 rs3014239 chr1:46089801 G/A cg03146154 chr1:46216737 IPP -0.8 -11.05 -0.56 1.34e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2099077 0.867 rs1428490 chr5:102798969 T/A cg07434438 chr16:72961899 ZFHX3 0.5 6.76 0.38 8.6e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs11122272 0.735 rs2024878 chr1:231528415 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.55 7.77 0.43 1.73e-13 Hemoglobin concentration; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23096297 chr20:61557774 DIDO1 -0.51 -6.59 -0.38 2.35e-10 Height; CESC trans rs11098499 0.710 rs6851130 chr4:120133712 G/A cg25214090 chr10:38739885 LOC399744 -0.54 -7.16 -0.4 7.81e-12 Corneal astigmatism; CESC cis rs6570726 0.967 rs413880 chr6:145804822 G/A cg05347473 chr6:146136440 FBXO30 0.42 5.6 0.33 5.29e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg16606324 chr3:10149918 C3orf24 0.43 5.22 0.31 3.71e-7 Alzheimer's disease; CESC cis rs3617 0.625 rs2245647 chr3:52862753 A/G cg11645453 chr3:52864694 ITIH4 0.25 5.2 0.3 3.93e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs9354308 0.933 rs2814134 chr6:66566658 C/G cg07460842 chr6:66804631 NA 0.68 7.68 0.43 3.08e-13 Metabolite levels; CESC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg12963246 chr6:28129442 ZNF389 0.58 7.78 0.43 1.61e-13 Depression; CESC cis rs10129255 0.957 rs11847726 chr14:107187355 T/C cg23076370 chr14:107095027 NA -0.44 -5.5 -0.32 9.06e-8 Kawasaki disease; CESC trans rs148734725 1 rs148734725 chr3:49406708 G/A cg21659725 chr3:3221576 CRBN -0.55 -6.52 -0.37 3.62e-10 Educational attainment (college completion); CESC cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg22875332 chr1:76189707 ACADM -0.57 -6.17 -0.35 2.5e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs13106227 0.576 rs6532417 chr4:77405719 T/G cg20311846 chr4:77356250 SHROOM3 -0.31 -6.04 -0.35 5.26e-9 Eosinophilic esophagitis (pediatric); CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg26335602 chr6:28129616 ZNF389 0.54 7.25 0.41 4.48e-12 Depression; CESC trans rs7937682 0.924 rs513425 chr11:111504861 C/T cg18187862 chr3:45730750 SACM1L 0.51 6.47 0.37 4.81e-10 Primary sclerosing cholangitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09828310 chr1:2452844 PANK4 0.48 6.72 0.38 1.12e-10 Fibrinogen levels; CESC cis rs7605827 0.930 rs1549015 chr2:15616458 T/C cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs3733585 0.673 rs4235347 chr4:9951956 C/T cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg12463550 chr7:65579703 CRCP 0.51 6.41 0.37 6.58e-10 Aortic root size; CESC cis rs7264396 0.676 rs6060729 chr20:34557004 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.18 0.36 2.37e-9 Total cholesterol levels; CESC cis rs7219021 0.518 rs6504584 chr17:46941419 G/T cg16584676 chr17:46985605 UBE2Z -0.41 -5.09 -0.3 6.71e-7 Schizophrenia or bipolar disorder; CESC trans rs9467711 0.606 rs9379897 chr6:26601526 T/C cg06606381 chr12:133084897 FBRSL1 -0.74 -7.14 -0.4 8.79e-12 Autism spectrum disorder or schizophrenia; CESC cis rs7772486 0.712 rs1292335 chr6:145967877 G/T cg23711669 chr6:146136114 FBXO30 0.66 9.76 0.51 2.02e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs4523957 0.928 rs216190 chr17:2187457 C/T cg16513277 chr17:2031491 SMG6 0.59 8.02 0.44 3.49e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2439831 0.850 rs694985 chr15:43813387 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.73 9.51 0.5 1.19e-18 Lung cancer in ever smokers; CESC cis rs734999 0.545 rs10910111 chr1:2542653 A/G cg20673091 chr1:2541236 MMEL1 0.44 7.65 0.43 3.63e-13 Ulcerative colitis; CESC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg25036284 chr2:26402008 FAM59B -0.83 -9.55 -0.51 9.32e-19 Gut microbiome composition (summer); CESC cis rs7429990 0.965 rs35689209 chr3:48119763 A/G cg11946769 chr3:48343235 NME6 -0.45 -5.53 -0.32 7.61e-8 Educational attainment (years of education); CESC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.62 0.33 4.92e-8 Bipolar disorder; CESC trans rs694739 0.595 rs11606015 chr11:64136877 C/G cg01888411 chr11:34378293 ABTB2 0.4 6.01 0.35 6e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs8114671 0.562 rs3818273 chr20:33509275 G/A cg07148914 chr20:33460835 GGT7 0.46 6.13 0.35 3.19e-9 Height; CESC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Parkinson's disease; CESC cis rs6688613 0.685 rs742048 chr1:166910145 A/C ch.1.3259774R chr1:166827647 TADA1 -0.55 -5.22 -0.31 3.69e-7 Refractive astigmatism; CESC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg23048001 chr7:2026167 MAD1L1 0.47 6.11 0.35 3.5e-9 Bipolar disorder and schizophrenia; CESC cis rs9929218 0.954 rs7199991 chr16:68818245 T/G cg02972257 chr16:68554789 NA 0.47 5.63 0.33 4.49e-8 Colorectal cancer; CESC cis rs1949733 0.877 rs940133 chr4:8473614 T/C cg11789530 chr4:8429930 ACOX3 0.78 8.81 0.48 1.66e-16 Response to antineoplastic agents; CESC cis rs34233420 1 rs34233420 chr17:38004929 GATTT/G cg19468946 chr17:37922297 IKZF3 -0.42 -5.78 -0.33 2.08e-8 Lymphocyte counts; CESC cis rs875971 0.658 rs432667 chr7:65514633 A/G cg18876405 chr7:65276391 NA 0.56 7.47 0.42 1.15e-12 Aortic root size; CESC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg00166722 chr3:10149974 C3orf24 0.45 5.65 0.33 4.12e-8 Alzheimer's disease; CESC cis rs8141529 0.764 rs5752812 chr22:29225603 T/A cg15103426 chr22:29168792 CCDC117 0.68 9.65 0.51 4.52e-19 Lymphocyte counts; CESC cis rs9303401 0.614 rs34900851 chr17:56566399 G/A cg12560992 chr17:57184187 TRIM37 0.52 5.05 0.3 8.23e-7 Cognitive test performance; CESC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.92 -0.52 6.14e-20 Developmental language disorder (linguistic errors); CESC cis rs722599 0.683 rs10144845 chr14:75237770 C/T cg08847533 chr14:75593920 NEK9 0.45 5.72 0.33 2.87e-8 IgG glycosylation; CESC cis rs6460942 0.558 rs4330594 chr7:12278615 G/A cg06484146 chr7:12443880 VWDE -0.54 -5.77 -0.33 2.26e-8 Coronary artery disease; CESC cis rs2354432 0.607 rs7545467 chr1:146746248 A/G cg25205988 chr1:146714368 CHD1L -0.94 -8.35 -0.46 3.88e-15 Mitochondrial DNA levels; CESC cis rs8067354 0.574 rs1292050 chr17:57965169 T/C cg13753209 chr17:57696993 CLTC 0.52 5.62 0.33 4.89e-8 Hemoglobin concentration; CESC cis rs17125944 0.505 rs10483618 chr14:53203590 T/C cg00686598 chr14:53173677 PSMC6 1.34 11.5 0.58 4.42e-25 Alzheimer's disease (late onset); CESC cis rs6691722 0.506 rs1016209 chr1:24745615 A/G cg18323236 chr1:24743029 NIPAL3 -0.48 -7.51 -0.42 8.94e-13 Response to interferon beta in multiple sclerosis; CESC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 10.03 0.52 2.83e-20 Platelet count; CESC cis rs2860975 0.666 rs1891073 chr10:96804911 G/A cg09036531 chr10:96991505 NA -0.37 -5.23 -0.31 3.42e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs7246657 0.943 rs3760825 chr19:37945601 C/T cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.69e-9 Coronary artery calcification; CESC cis rs4843747 0.518 rs4072777 chr16:88107030 G/A cg06374794 chr16:88002281 BANP 0.39 5.16 0.3 4.78e-7 Menopause (age at onset); CESC cis rs2034088 0.965 rs4968070 chr17:446162 A/G cg06217071 chr17:408420 NA 0.46 7.83 0.43 1.17e-13 Hip circumference adjusted for BMI; CESC cis rs7568498 0.564 rs10490563 chr2:161914168 G/A cg08807892 chr2:162101083 NA -0.54 -5.97 -0.34 7.69e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs3760982 0.585 rs8109812 chr19:44298494 C/A cg11993925 chr19:44307056 LYPD5 0.33 5.56 0.32 6.54e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC trans rs2965280 0.793 rs8104344 chr19:34840228 C/T cg05799317 chr6:165723796 C6orf118 0.81 6.0 0.35 6.45e-9 Colorectal cancer; CESC cis rs367615 0.704 rs6889301 chr5:108835181 C/T cg17395555 chr5:108820864 NA 0.62 11.06 0.56 1.27e-23 Colorectal cancer (SNP x SNP interaction); CESC cis rs7219021 0.961 rs67469980 chr17:46878250 C/G cg16584676 chr17:46985605 UBE2Z -0.59 -6.71 -0.38 1.2e-10 Schizophrenia or bipolar disorder; CESC cis rs7973683 0.541 rs57078519 chr12:124388784 G/A cg12597309 chr12:124393772 DNAH10 0.25 5.46 0.32 1.08e-7 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11287903 chr10:115613834 DCLRE1A;NHLRC2 0.5 6.38 0.36 7.87e-10 Gut microbiota (bacterial taxa); CESC cis rs4808199 0.649 rs12983940 chr19:19516431 G/A cg03709012 chr19:19516395 GATAD2A 1.13 13.56 0.64 3.46e-32 Nonalcoholic fatty liver disease; CESC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg25036284 chr2:26402008 FAM59B 0.64 6.16 0.35 2.75e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs2180341 0.781 rs6913350 chr6:127570560 C/T cg24812749 chr6:127587940 RNF146 0.84 11.9 0.59 1.98e-26 Breast cancer; CESC cis rs847577 0.646 rs10270222 chr7:97781799 C/T cg24562669 chr7:97807699 LMTK2 -0.57 -8.48 -0.46 1.6e-15 Breast cancer; CESC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg09365446 chr1:150670422 GOLPH3L -0.39 -5.07 -0.3 7.43e-7 Blood protein levels; CESC cis rs17655565 1.000 rs76413558 chr12:52694156 A/G cg08257133 chr12:52711352 KRT83 0.5 5.81 0.34 1.78e-8 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs4849845 0.812 rs7593660 chr2:121026652 T/A cg24070213 chr2:121070622 NA 0.39 5.04 0.3 8.71e-7 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03154536 chr11:107799237 RAB39 0.46 6.54 0.37 3.16e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs11640188 chr16:89807732 C/T cg00800038 chr16:89945340 TCF25 -0.88 -7.38 -0.41 2.03e-12 Skin colour saturation; CESC cis rs524281 0.773 rs2017969 chr11:66039032 G/A cg14036092 chr11:66035641 RAB1B -0.55 -5.38 -0.31 1.62e-7 Electroencephalogram traits; CESC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg10883421 chr6:151773342 RMND1;C6orf211 0.86 14.05 0.65 6.77e-34 Menarche (age at onset); CESC cis rs11958404 0.546 rs10475647 chr5:157443489 A/G cg05962755 chr5:157440814 NA 0.42 6.11 0.35 3.54e-9 IgG glycosylation; CESC cis rs703842 0.642 rs73123375 chr12:58063664 C/T cg18357645 chr12:58087776 OS9 -0.55 -7.33 -0.41 2.74e-12 Multiple sclerosis; CESC cis rs35110281 0.805 rs2838318 chr21:44991825 G/A cg04455712 chr21:45112962 RRP1B 0.37 5.59 0.32 5.67e-8 Mean corpuscular volume; CESC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.21 -0.36 2.01e-9 Schizophrenia; CESC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg18402987 chr7:1209562 NA 0.76 8.5 0.46 1.38e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs911555 0.755 rs10144051 chr14:103885931 A/C cg09975044 chr14:104007538 NA 0.45 5.62 0.33 4.78e-8 Intelligence (multi-trait analysis); CESC cis rs4523957 0.928 rs216220 chr17:2148821 G/T cg16513277 chr17:2031491 SMG6 0.59 8.2 0.45 1.04e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs35110281 0.837 rs12627667 chr21:45071396 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 7.01 0.4 1.99e-11 Mean corpuscular volume; CESC cis rs2074585 0.713 rs2589941 chr15:90931457 C/T cg22089800 chr15:90895588 ZNF774 0.68 9.5 0.5 1.35e-18 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs1355223 0.583 rs2941043 chr11:34870994 A/G cg11058730 chr11:34937778 PDHX;APIP -0.8 -12.11 -0.6 3.65e-27 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs4072980 0.524 rs28477803 chr1:38398694 C/T cg12658694 chr1:38397304 INPP5B 0.72 10.25 0.53 5.44e-21 Coronary artery disease; CESC cis rs763121 0.853 rs138702 chr22:39132601 A/T cg06544989 chr22:39130855 UNC84B -0.49 -8.79 -0.48 1.95e-16 Menopause (age at onset); CESC cis rs4948102 0.595 rs10255049 chr7:56121304 G/A cg09872392 chr7:56161020 PHKG1 -0.42 -6.84 -0.39 5.32e-11 Plasma homocysteine levels (post-methionine load test); CESC cis rs7524258 0.903 rs4908449 chr1:7292700 T/C cg07173049 chr1:7289937 CAMTA1 0.47 7.14 0.4 9e-12 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs1580019 0.587 rs7806941 chr7:32553319 G/T cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.98 0.76 2.51e-51 Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24028381 chr8:145133668 EXOSC4 0.64 7.79 0.43 1.5e-13 Gut microbiome composition (summer); CESC trans rs1814175 0.645 rs1722000 chr11:49917928 A/C cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs11583043 0.918 rs56402739 chr1:101397133 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.55 6.34 0.36 9.81e-10 Ulcerative colitis;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17951368 chr11:17298273 NUCB2 0.58 6.5 0.37 3.92e-10 Gut microbiome composition (summer); CESC cis rs7818382 0.967 rs7812465 chr8:96050557 C/T cg13393036 chr8:95962371 TP53INP1 0.41 8.55 0.46 9.96e-16 Alzheimer's disease (late onset); CESC cis rs1832871 0.711 rs9457300 chr6:158714609 G/C cg07165851 chr6:158734300 TULP4 0.6 6.59 0.38 2.33e-10 Height; CESC cis rs2066819 1.000 rs2066818 chr12:56753822 C/A cg26734620 chr12:56694298 CS 0.97 5.8 0.34 1.87e-8 Psoriasis vulgaris; CESC cis rs1957429 0.572 rs3813421 chr14:65347239 G/A cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC cis rs6088590 0.707 rs67159833 chr20:33488079 T/C cg24642439 chr20:33292090 TP53INP2 0.85 11.05 0.56 1.34e-23 Coronary artery disease; CESC cis rs344364 0.511 rs337286 chr16:1965719 C/T cg26617929 chr16:1858877 NA -0.53 -5.19 -0.3 4.17e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs7771547 0.573 rs9470278 chr6:36399239 G/A cg07856975 chr6:36356162 ETV7 -0.36 -5.38 -0.31 1.67e-7 Platelet distribution width; CESC cis rs11098499 0.774 rs73842616 chr4:120290683 G/A cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs10905065 0.965 rs7078711 chr10:5744985 C/G cg11519256 chr10:5708881 ASB13 0.43 5.82 0.34 1.68e-8 Menopause (age at onset); CESC cis rs9811920 0.683 rs4928230 chr3:99661963 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -6.16 -0.35 2.73e-9 Axial length; CESC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.62 7.6 0.42 5.15e-13 Height; CESC cis rs3540 0.597 rs4932346 chr15:91048991 T/C cg10434728 chr15:90938212 IQGAP1 -0.4 -7.16 -0.4 8.07e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg16339924 chr4:17578868 LAP3 0.66 8.2 0.45 1.05e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7264396 0.690 rs2425164 chr20:34434916 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.33 -0.57 1.61e-24 Total cholesterol levels; CESC cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg10523679 chr1:76189770 ACADM -0.61 -6.16 -0.35 2.75e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7000551 0.527 rs12677619 chr8:22243326 G/A cg12081754 chr8:22256438 SLC39A14 0.92 12.12 0.6 3.45e-27 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg03609598 chr5:56110824 MAP3K1 -0.51 -5.54 -0.32 7.13e-8 Initial pursuit acceleration; CESC cis rs3741404 0.512 rs4980504 chr11:63873083 G/A cg05555928 chr11:63887634 MACROD1 0.44 6.35 0.36 9.18e-10 Platelet count; CESC cis rs1728785 1.000 rs1645935 chr16:68563791 A/C cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs1707322 1.000 rs6429588 chr1:46454058 T/G cg03146154 chr1:46216737 IPP 0.75 10.29 0.53 4.13e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg18876405 chr7:65276391 NA 0.56 7.48 0.42 1.12e-12 Aortic root size; CESC cis rs17666538 0.585 rs4333567 chr8:636611 C/T cg13264159 chr8:625131 ERICH1 -0.81 -5.37 -0.31 1.76e-7 IgG glycosylation; CESC cis rs8072100 0.666 rs9913014 chr17:45460189 C/T cg08085267 chr17:45401833 C17orf57 -0.51 -6.49 -0.37 4.12e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7833986 0.501 rs17815934 chr8:57038395 G/A cg26371346 chr8:56986568 SNORD54;RPS20 0.56 5.04 0.3 8.57e-7 Height; CESC cis rs7264396 0.561 rs6060741 chr20:34571484 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.61 6.94 0.39 2.96e-11 Total cholesterol levels; CESC cis rs4820294 1.000 rs4820294 chr22:38071043 G/A cg21798802 chr22:38057573 PDXP 0.46 7.94 0.44 5.92e-14 Fat distribution (HIV); CESC cis rs11252926 0.624 rs7085214 chr10:468133 A/G cg18196295 chr10:418757 DIP2C 0.52 7.1 0.4 1.12e-11 Psychosis in Alzheimer's disease; CESC cis rs2250402 0.510 rs2291619 chr15:40329033 C/T cg16127683 chr15:40268777 EIF2AK4 0.67 6.27 0.36 1.45e-9 Corneal curvature; CESC trans rs2018683 0.707 rs4719961 chr7:28969513 C/T cg19402173 chr7:128379420 CALU -0.54 -7.32 -0.41 2.96e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs1878931 0.580 rs8062722 chr16:3409161 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.94 14.22 0.66 1.67e-34 Body mass index (adult); CESC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.54 -6.67 -0.38 1.49e-10 Prudent dietary pattern; CESC cis rs561341 1.000 rs55959993 chr17:30254771 C/G cg12193833 chr17:30244370 NA -0.76 -6.85 -0.39 5.14e-11 Hip circumference adjusted for BMI; CESC cis rs5753618 0.504 rs9606848 chr22:31901867 G/A cg02404636 chr22:31891804 SFI1 0.42 5.85 0.34 1.47e-8 Colorectal cancer; CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg27094323 chr7:1216898 NA -0.37 -5.06 -0.3 7.7300000000000005e-07 Longevity;Endometriosis; CESC cis rs7116495 1.000 rs7128317 chr11:71701367 C/T cg10381502 chr11:71823885 C11orf51 0.63 5.49 0.32 9.25e-8 Severe influenza A (H1N1) infection; CESC cis rs4253772 0.530 rs9615349 chr22:46732418 T/G cg24881330 chr22:46731750 TRMU 0.81 5.76 0.33 2.32e-8 LDL cholesterol;Cholesterol, total; CESC cis rs5753618 0.561 rs2073857 chr22:31658281 A/G cg13145458 chr22:31556086 RNF185 0.47 5.27 0.31 2.83e-7 Colorectal cancer; CESC cis rs763121 0.853 rs138712 chr22:39141600 C/T cg06022373 chr22:39101656 GTPBP1 0.92 15.99 0.7 9.42e-41 Menopause (age at onset); CESC trans rs7937682 0.924 rs4630327 chr11:111539327 C/T cg18187862 chr3:45730750 SACM1L -0.48 -6.32 -0.36 1.13e-9 Primary sclerosing cholangitis; CESC cis rs9902453 0.899 rs1979572 chr17:28511978 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 7.46 0.42 1.25e-12 Coffee consumption (cups per day); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21989500 chr16:23607577 NDUFAB1 0.46 6.16 0.35 2.75e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs9884501 chr4:98893721 A/C cg05340658 chr4:99064831 C4orf37 0.74 10.9 0.56 4.09e-23 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg18876405 chr7:65276391 NA 0.5 5.88 0.34 1.2e-8 Aortic root size; CESC cis rs36051895 0.623 rs1120679 chr9:5248073 C/G cg02405213 chr9:5042618 JAK2 -0.54 -6.57 -0.37 2.65e-10 Pediatric autoimmune diseases; CESC cis rs7089973 0.604 rs11196947 chr10:116601372 G/A cg03647239 chr10:116582469 FAM160B1 0.43 5.35 0.31 1.94e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6968419 0.755 rs6967695 chr7:115896049 G/A cg02561103 chr7:115862891 TES -0.41 -5.35 -0.31 1.92e-7 Intraocular pressure; CESC cis rs1801251 1.000 rs35085837 chr2:233624363 A/G cg08000102 chr2:233561755 GIGYF2 0.67 9.48 0.5 1.53e-18 Coronary artery disease; CESC cis rs34602589 0.535 rs7346579 chr20:43844722 A/G cg10761708 chr20:43804764 PI3 0.48 5.61 0.33 5.1e-8 Parental longevity (mother's age at death); CESC trans rs66573146 0.831 rs6851488 chr4:6987412 C/T cg07817883 chr1:32538562 TMEM39B 0.96 6.93 0.39 3.23e-11 Granulocyte percentage of myeloid white cells; CESC cis rs78132593 0.718 rs72702521 chr1:150650194 C/T cg18945601 chr1:151320034 RFX5 -0.54 -5.07 -0.3 7.53e-7 High light scatter reticulocyte count; CESC cis rs5758659 0.904 rs5758653 chr22:42613485 G/T cg15557168 chr22:42548783 NA -0.49 -7.7 -0.43 2.75e-13 Cognitive function; CESC cis rs1348850 0.645 rs11889272 chr2:178432378 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.68 7.05 0.4 1.54e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6545883 0.929 rs13413337 chr2:61747123 A/G cg15711740 chr2:61764176 XPO1 -0.42 -5.2 -0.3 3.95e-7 Tuberculosis; CESC cis rs9611565 0.512 rs4820446 chr22:42215684 C/T cg06634786 chr22:41940651 POLR3H -0.69 -6.79 -0.38 7.45e-11 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06119275 chr12:133384736 GOLGA3 0.43 6.08 0.35 4.19e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04199396 chr11:118230165 UBE4A -0.56 -6.11 -0.35 3.45e-9 Gut microbiome composition (summer); CESC cis rs4930103 0.935 rs4930098 chr11:2020955 G/C cg23202291 chr11:1979235 NA 0.35 5.04 0.3 8.79e-7 DNA methylation (parent-of-origin);DNA methylation (variation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20618750 chr5:149380010 HMGXB3;TIGD6 -0.67 -7.83 -0.43 1.19e-13 Gut microbiome composition (summer); CESC cis rs6967414 0.792 rs6954012 chr7:6755724 A/C cg00387323 chr7:6746715 ZNF12 0.57 5.82 0.34 1.66e-8 Hematocrit;Hemoglobin concentration; CESC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg07507251 chr3:52567010 NT5DC2 0.4 7.06 0.4 1.49e-11 Bipolar disorder; CESC cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.32 -5.57 -0.32 6.4e-8 Hemoglobin concentration; CESC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg04166393 chr7:2884313 GNA12 0.55 7.0 0.4 2.04e-11 Height; CESC cis rs7267979 0.844 rs8184820 chr20:25250577 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.69 -11.22 -0.57 3.72e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs2286503 0.839 rs4722188 chr7:22860211 C/G cg13679077 chr7:22862647 TOMM7 0.48 6.29 0.36 1.27e-9 Fibrinogen; CESC cis rs10504229 0.679 rs10504217 chr8:58037522 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -5.84 -0.34 1.53e-8 Developmental language disorder (linguistic errors); CESC cis rs1065852 0.526 rs59993856 chr22:42403980 C/T cg22189786 chr22:42395067 WBP2NL 0.41 5.18 0.3 4.48e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04419871 chr3:197409435 KIAA0226 -0.62 -7.06 -0.4 1.45e-11 Gut microbiome composition (summer); CESC cis rs2276314 0.857 rs62101376 chr18:33582955 T/C cg05985134 chr18:33552581 C18orf21 0.59 6.71 0.38 1.18e-10 Endometriosis;Drug-induced torsades de pointes; CESC cis rs9457247 0.612 rs2237273 chr6:167443017 T/C cg23791538 chr6:167370224 RNASET2 -0.56 -7.6 -0.42 5.05e-13 Crohn's disease; CESC cis rs2204008 0.658 rs11181310 chr12:38315963 C/A cg26384229 chr12:38710491 ALG10B 0.69 10.3 0.53 3.84e-21 Bladder cancer; CESC cis rs637571 0.522 rs503524 chr11:65751764 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 5.99 0.35 6.81e-9 Eosinophil percentage of white cells; CESC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg25036284 chr2:26402008 FAM59B -0.57 -6.61 -0.38 2.09e-10 Gut microbiome composition (summer); CESC cis rs6032067 0.929 rs6017511 chr20:43833132 C/T cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.56e-7 Blood protein levels; CESC cis rs2637266 0.600 rs2395430 chr10:78465471 G/A cg18941641 chr10:78392320 NA 0.41 7.43 0.41 1.54e-12 Pulmonary function; CESC cis rs2239547 0.657 rs7638524 chr3:52874861 G/A cg11645453 chr3:52864694 ITIH4 0.34 6.34 0.36 9.85e-10 Schizophrenia; CESC cis rs6032067 0.929 rs13039213 chr20:43805712 A/C cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.5e-8 Blood protein levels; CESC cis rs9457247 0.765 rs9459836 chr6:167419105 G/A cg07741184 chr6:167504864 NA 0.35 6.48 0.37 4.36e-10 Crohn's disease; CESC cis rs4889855 0.530 rs4890047 chr17:78549439 A/G cg16591659 chr17:78472290 NA -0.34 -5.88 -0.34 1.25e-8 Fractional excretion of uric acid; CESC cis rs9811920 0.535 rs704577 chr3:99487375 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.34 -5.44 -0.32 1.18e-7 Axial length; CESC cis rs5769765 0.913 rs8135071 chr22:50299587 T/C cg26441486 chr22:50317300 CRELD2 0.39 5.33 0.31 2.11e-7 Schizophrenia; CESC cis rs2795502 1.000 rs2795502 chr10:43340662 G/A cg20628663 chr10:43360327 NA -0.61 -7.24 -0.41 4.87e-12 Blood protein levels; CESC cis rs6761276 0.649 rs3827763 chr2:113831289 C/T cg12858261 chr2:113808755 IL1F8 -0.44 -5.48 -0.32 9.98e-8 Protein quantitative trait loci; CESC cis rs524281 0.861 rs10896081 chr11:65880354 A/T cg14036092 chr11:66035641 RAB1B -0.56 -5.88 -0.34 1.2e-8 Electroencephalogram traits; CESC cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg02079420 chr8:82753780 SNX16 0.57 7.66 0.43 3.44e-13 Diastolic blood pressure; CESC cis rs425277 1.000 rs196128 chr1:2078444 T/G cg16545954 chr1:2118288 C1orf86 0.33 5.6 0.33 5.35e-8 Height; CESC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg27170947 chr2:26402098 FAM59B -0.6 -7.24 -0.41 4.78e-12 Gut microbiome composition (summer); CESC cis rs2014572 0.933 rs8109882 chr19:57755618 C/G cg12963866 chr19:57752005 ZNF805 -0.48 -6.47 -0.37 4.63e-10 Hyperactive-impulsive symptoms; CESC cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.74 11.1 0.56 9.17e-24 Monocyte percentage of white cells; CESC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg04414720 chr1:150670196 GOLPH3L 0.45 5.96 0.34 8.16e-9 Melanoma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05669157 chr7:72742156 TRIM50;FKBP6 0.54 7.47 0.42 1.19e-12 Fibrinogen levels; CESC trans rs10905099 0.708 rs12354420 chr10:7096717 A/G cg05230642 chr15:25439252 SNORD115-14 -0.73 -6.17 -0.35 2.6e-9 Orofacial clefts; CESC trans rs7615952 0.576 rs12497295 chr3:125818650 G/A cg07211511 chr3:129823064 LOC729375 -0.57 -6.28 -0.36 1.38e-9 Blood pressure (smoking interaction); CESC cis rs1153858 1.000 rs12593370 chr15:45617417 C/T cg14582100 chr15:45693742 SPATA5L1 0.4 5.62 0.33 4.8e-8 Homoarginine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03654279 chr20:62612439 PRPF6;SAMD10 0.74 8.06 0.44 2.58e-14 Gut microbiome composition (summer); CESC cis rs2066819 0.818 rs703830 chr12:56701872 T/C cg26316697 chr12:56727976 PAN2 -0.69 -6.58 -0.37 2.52e-10 Psoriasis vulgaris; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg09681335 chr6:74233510 NA 0.44 6.01 0.35 6.07e-9 Post-traumatic stress disorder; CESC cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg24110177 chr3:50126178 RBM5 0.53 7.36 0.41 2.28e-12 Intelligence (multi-trait analysis); CESC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.34 0.5 3.98e-18 Menopause (age at onset); CESC cis rs854765 0.663 rs4925120 chr17:17754633 C/T cg09796270 chr17:17721594 SREBF1 -0.46 -6.71 -0.38 1.17e-10 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06757187 chr22:19110190 DGCR2 0.68 7.85 0.43 1.01e-13 Gut microbiome composition (summer); CESC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg01416388 chr22:39784598 NA -0.67 -7.82 -0.43 1.24e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs6912958 0.712 rs7772561 chr6:88331299 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.26 -0.31 2.95e-7 Monocyte percentage of white cells; CESC cis rs881375 0.692 rs2072438 chr9:123651301 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.49 6.99 0.39 2.27e-11 Rheumatoid arthritis; CESC cis rs12765878 1.000 rs11191848 chr10:105650837 T/C cg24587175 chr10:105670608 OBFC1 0.32 5.36 0.31 1.81e-7 Coronary artery disease; CESC cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.69 -10.89 -0.56 4.48e-23 Personality dimensions; CESC cis rs9303401 0.659 rs7210700 chr17:56668186 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.56e-29 Cognitive test performance; CESC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg16405210 chr4:1374714 KIAA1530 -0.53 -7.02 -0.4 1.86e-11 Longevity; CESC cis rs8020095 0.571 rs2039055 chr14:67580793 A/C cg19548862 chr14:67692701 FAM71D -0.5 -6.18 -0.36 2.38e-9 Depression (quantitative trait); CESC cis rs7762018 0.882 rs4716342 chr6:170137959 A/G cg05834625 chr6:170176447 C6orf70 0.63 6.97 0.39 2.5e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7927592 0.717 rs7126451 chr11:68257386 A/G cg20283391 chr11:68216788 NA 0.44 5.62 0.33 4.9e-8 Total body bone mineral density; CESC trans rs561341 0.700 rs886223 chr17:30229877 G/T cg20587970 chr11:113659929 NA -0.63 -8.23 -0.45 8.49e-15 Hip circumference adjusted for BMI; CESC cis rs3820068 0.608 rs7516683 chr1:16020502 A/G cg13390004 chr1:15929781 NA -0.33 -5.3 -0.31 2.41e-7 Systolic blood pressure; CESC cis rs8060686 0.641 rs3743735 chr16:68119555 G/A cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 4.92e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs6835098 1.000 rs4561909 chr4:174086937 A/T cg08422745 chr4:174089978 GALNT7 -0.74 -9.68 -0.51 3.55e-19 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs1348850 0.914 rs7587604 chr2:178309848 T/A cg23306229 chr2:178417860 TTC30B 0.6 7.84 0.43 1.12e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg09365446 chr1:150670422 GOLPH3L 0.39 5.27 0.31 2.86e-7 Melanoma; CESC trans rs7126679 0.544 rs672981 chr11:88623113 T/G cg08270734 chr12:108951574 SART3 0.47 6.16 0.35 2.65e-9 Depressive symptoms; CESC cis rs9309473 0.687 rs6710659 chr2:73607510 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -6.43 -0.37 5.85e-10 Metabolite levels; CESC cis rs4727963 0.837 rs10258768 chr7:122799240 C/A cg03640110 chr7:122635026 TAS2R16 0.33 5.07 0.3 7.45e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg23711669 chr6:146136114 FBXO30 1.03 16.03 0.7 6.76e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs4589502 0.800 rs12595796 chr15:67202599 A/G cg12317470 chr15:67143691 NA -0.67 -7.8 -0.43 1.38e-13 Lung cancer (smoking interaction); CESC cis rs7191439 0.858 rs2290902 chr16:88782676 A/G cg02389323 chr16:88786976 FAM38A 0.88 7.33 0.41 2.71e-12 Plateletcrit; CESC cis rs4889855 0.556 rs74003969 chr17:78526212 C/T cg16591659 chr17:78472290 NA 0.39 6.35 0.36 9.31e-10 Fractional excretion of uric acid; CESC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg22535103 chr8:58192502 C8orf71 -0.94 -9.92 -0.52 6.46e-20 Developmental language disorder (linguistic errors); CESC cis rs7072216 0.763 rs2147901 chr10:100165496 A/C cg26618903 chr10:100175079 PYROXD2 0.33 5.18 0.3 4.37e-7 Metabolite levels; CESC cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.21 0.31 3.72e-7 Colonoscopy-negative controls vs population controls; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04650786 chr6:108395545 OSTM1 -0.46 -6.0 -0.35 6.39e-9 Height; CESC cis rs72781680 1.000 rs6751655 chr2:24155478 A/G cg20701182 chr2:24300061 SF3B14 0.71 6.32 0.36 1.12e-9 Lymphocyte counts; CESC cis rs12155623 0.504 rs10808736 chr8:49873039 C/A cg22283653 chr8:49824208 NA 0.39 5.83 0.34 1.63e-8 Sudden cardiac arrest; CESC cis rs941873 0.772 rs1316312 chr10:81110417 G/C cg09469691 chr10:81107165 PPIF 0.53 7.03 0.4 1.8e-11 Height; CESC cis rs7809950 0.798 rs10281535 chr7:107229618 T/G cg23024343 chr7:107201750 COG5 0.41 5.68 0.33 3.5e-8 Coronary artery disease; CESC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg23758822 chr17:41437982 NA 1.03 15.87 0.7 2.47e-40 Menopause (age at onset); CESC cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg22903471 chr2:27725779 GCKR -0.53 -7.16 -0.4 8.08e-12 Total body bone mineral density; CESC cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg18180107 chr4:99064573 C4orf37 0.4 5.21 0.31 3.72e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2985684 0.948 rs2883437 chr14:50031666 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.44 -5.29 -0.31 2.55e-7 Carotid intima media thickness; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10156544 chr12:104324016 LOC253724;HSP90B1 -0.44 -6.05 -0.35 5.04e-9 Fibrinogen levels; CESC cis rs9868809 0.881 rs2310996 chr3:48671834 T/C cg06212747 chr3:49208901 KLHDC8B -0.59 -5.15 -0.3 5.19e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs10463316 0.817 rs6879238 chr5:150820574 G/C cg03212797 chr5:150827313 SLC36A1 -0.48 -6.32 -0.36 1.13e-9 Metabolite levels (Pyroglutamine); CESC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg03351412 chr1:154909251 PMVK 0.7 9.52 0.5 1.11e-18 Prostate cancer; CESC cis rs244293 0.695 rs9303360 chr17:53001456 T/C cg19360675 chr17:53046073 COX11;STXBP4 -0.49 -6.6 -0.38 2.29e-10 Menarche (age at onset); CESC cis rs748404 0.676 rs4401024 chr15:43650335 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.57 0.42 6.2e-13 Lung cancer; CESC cis rs72634258 0.553 rs112697022 chr1:7949253 G/A cg00042356 chr1:8021962 PARK7 0.56 5.11 0.3 6.03e-7 Inflammatory bowel disease; CESC cis rs7267979 1.000 rs4813563 chr20:25365340 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.5 -0.71 1.44e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs796364 0.616 rs7589545 chr2:200676102 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.55 5.18 0.3 4.37e-7 Schizophrenia; CESC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.38 0.31 1.6e-7 Personality dimensions; CESC cis rs4319547 0.695 rs10734915 chr12:122873408 A/C cg05707623 chr12:122985044 ZCCHC8 -0.52 -6.21 -0.36 2.05e-9 Body mass index; CESC cis rs1568889 1.000 rs7934085 chr11:28369660 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.86 0.55 5.8e-23 Bipolar disorder; CESC cis rs924607 0.931 rs1709556 chr5:637058 A/G cg09021430 chr5:549028 NA -0.39 -6.88 -0.39 4.32e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs2997447 0.748 rs2802346 chr1:26434354 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.57 5.04 0.3 8.68e-7 QRS complex (12-leadsum); CESC cis rs703842 1.000 rs8181644 chr12:58173466 A/G cg00677455 chr12:58241039 CTDSP2 0.54 7.01 0.4 1.93e-11 Multiple sclerosis; CESC cis rs9815354 0.953 rs7631914 chr3:41813557 T/C cg03022575 chr3:42003672 ULK4 0.46 5.04 0.3 8.45e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs881375 0.678 rs2269060 chr9:123683569 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 5.75 0.33 2.45e-8 Rheumatoid arthritis; CESC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.99e-8 Eye color traits; CESC trans rs35883536 1.000 rs3904672 chr1:101136651 C/T cg16931499 chr17:42786676 DBF4B 0.42 6.14 0.35 2.99e-9 Monocyte count; CESC cis rs9790314 0.846 rs6441371 chr3:161008727 C/A cg04691961 chr3:161091175 C3orf57 -0.41 -5.37 -0.31 1.7e-7 Morning vs. evening chronotype; CESC cis rs14403 1.000 rs12406958 chr1:243662190 T/C cg21452805 chr1:244014465 NA 0.49 5.75 0.33 2.48e-8 Schizophrenia; CESC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg15147215 chr3:52552868 STAB1 -0.31 -5.26 -0.31 2.98e-7 Electroencephalogram traits; CESC cis rs3736485 0.966 rs11070854 chr15:51808365 A/G cg08986416 chr15:51914746 DMXL2 -0.4 -5.16 -0.3 4.85e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7130144 0.541 rs1921573 chr11:130461493 A/T cg26307797 chr11:130446613 NA -0.74 -6.36 -0.36 8.72e-10 Urate levels in lean individuals; CESC cis rs6964587 1.000 rs2299232 chr7:91626699 A/C cg17063962 chr7:91808500 NA 0.55 7.43 0.42 1.53e-12 Breast cancer; CESC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg01448562 chr3:133502909 NA -0.45 -6.14 -0.35 2.96e-9 Iron status biomarkers; CESC cis rs6701037 0.748 rs10912901 chr1:175138602 G/A cg00321850 chr1:175162397 KIAA0040 -0.42 -6.04 -0.35 5.06e-9 Alcohol dependence; CESC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg10862848 chr6:42927986 GNMT -0.3 -7.48 -0.42 1.13e-12 Alzheimer's disease in APOE e4+ carriers; CESC cis rs896854 0.902 rs726816 chr8:95968413 T/G cg23172400 chr8:95962367 TP53INP1 -0.46 -9.39 -0.5 2.87e-18 Type 2 diabetes; CESC cis rs73206853 0.764 rs55887805 chr12:110597246 T/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.62 0.33 4.79e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs4566357 0.964 rs2396443 chr2:227921208 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -5.29 -0.31 2.58e-7 Coronary artery disease; CESC cis rs6032067 0.929 rs13038355 chr20:43805555 C/T cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.5e-8 Blood protein levels; CESC cis rs66887589 0.807 rs7694483 chr4:120405929 T/A cg09307838 chr4:120376055 NA 0.54 7.16 0.4 8.19e-12 Diastolic blood pressure; CESC cis rs61931739 0.817 rs1705771 chr12:34174950 C/G cg19457237 chr12:34500585 NA -0.37 -5.2 -0.3 3.94e-7 Morning vs. evening chronotype; CESC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg00166722 chr3:10149974 C3orf24 0.49 6.04 0.35 5.3e-9 Alzheimer's disease; CESC cis rs2279817 0.863 rs12749985 chr1:18026004 C/T cg21791023 chr1:18019539 ARHGEF10L -0.55 -8.26 -0.45 6.78e-15 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02050560 chr22:42486888 NDUFA6 0.56 6.54 0.37 3.14e-10 Gut microbiome composition (summer); CESC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg11644478 chr21:40555479 PSMG1 -0.79 -11.66 -0.58 1.23e-25 Cognitive function; CESC trans rs9388451 0.626 rs1935983 chr6:126068914 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.66 -9.31 -0.5 4.92e-18 Brugada syndrome; CESC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg13866156 chr1:1669148 SLC35E2 -0.49 -6.54 -0.37 3.1e-10 Body mass index; CESC cis rs4664293 0.967 rs6432548 chr2:160545537 T/C cg08347373 chr2:160653686 CD302 -0.31 -5.1 -0.3 6.5e-7 Monocyte percentage of white cells; CESC cis rs7818688 0.697 rs58314911 chr8:95985111 G/A cg16049864 chr8:95962084 TP53INP1 0.57 5.73 0.33 2.68e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs4969178 0.965 rs16971107 chr17:76394042 C/T cg20026190 chr17:76395443 PGS1 0.49 7.99 0.44 4.2e-14 HDL cholesterol levels; CESC cis rs8180040 0.620 rs2305635 chr3:47043622 G/A cg27129171 chr3:47204927 SETD2 -0.67 -9.72 -0.51 2.72e-19 Colorectal cancer; CESC cis rs911555 0.692 rs7145753 chr14:103866100 G/A cg24130564 chr14:104152367 KLC1 0.44 5.79 0.33 2.03e-8 Intelligence (multi-trait analysis); CESC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg26338869 chr17:61819248 STRADA 0.7 9.31 0.5 5.07e-18 Prudent dietary pattern; CESC cis rs1371867 0.875 rs1788187 chr8:101336099 A/G cg11906718 chr8:101322791 RNF19A 0.46 5.91 0.34 1.03e-8 Atrioventricular conduction; CESC cis rs4819052 0.851 rs2838866 chr21:46713014 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.49 6.14 0.35 2.95e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8072100 1.000 rs3809868 chr17:45750596 G/A cg08085267 chr17:45401833 C17orf57 0.41 5.44 0.32 1.21e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2952156 0.920 rs2941506 chr17:37833035 A/G cg07936489 chr17:37558343 FBXL20 -0.58 -7.33 -0.41 2.84e-12 Asthma; CESC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs1105307 0.734 rs7025471 chr9:72159380 G/A cg17994569 chr10:50821652 CHAT -0.28 -6.06 -0.35 4.65e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg22920501 chr2:26401640 FAM59B -0.8 -8.75 -0.47 2.48e-16 Gut microbiome composition (summer); CESC cis rs2820292 0.804 rs2644120 chr1:201882277 C/G cg06775570 chr1:201857621 SHISA4 0.33 5.57 0.32 6.15e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs2239547 0.522 rs9846976 chr3:53007995 T/C cg11645453 chr3:52864694 ITIH4 0.33 5.46 0.32 1.08e-7 Schizophrenia; CESC cis rs12545109 0.959 rs12547974 chr8:57314785 G/T cg09654669 chr8:57350985 NA -0.58 -6.97 -0.39 2.44e-11 Obesity-related traits; CESC cis rs11098499 0.697 rs10020027 chr4:120381879 G/C cg09307838 chr4:120376055 NA 0.96 13.95 0.65 1.6e-33 Corneal astigmatism; CESC cis rs1847505 0.559 rs2323133 chr13:61568946 G/A cg25164009 chr13:61490935 NA -0.41 -5.49 -0.32 9.53e-8 Polychlorinated biphenyl levels; CESC cis rs941873 0.803 rs5015119 chr10:81101609 G/C cg11057378 chr10:81107060 PPIF 0.37 5.86 0.34 1.36e-8 Height; CESC cis rs7762018 1.000 rs7747645 chr6:170070291 G/C cg05834625 chr6:170176447 C6orf70 0.62 7.46 0.42 1.25e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8177179 0.967 rs4994581 chr3:133437563 T/C cg16262614 chr3:133464971 TF 0.38 7.36 0.41 2.37e-12 Iron status biomarkers (transferrin levels); CESC cis rs6547741 1.000 rs7604798 chr2:27824940 T/C cg27432699 chr2:27873401 GPN1 0.49 6.94 0.39 3.02e-11 Oral cavity cancer; CESC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.68 -0.51 3.46e-19 Alzheimer's disease; CESC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.6 7.28 0.41 3.77e-12 Height; CESC cis rs35110281 0.626 rs162388 chr21:44936032 G/A cg21573476 chr21:45109991 RRP1B -0.35 -5.15 -0.3 5.01e-7 Mean corpuscular volume; CESC cis rs3785574 0.743 rs2727334 chr17:61969063 A/T cg11494091 chr17:61959527 GH2 0.37 5.09 0.3 6.71e-7 Height; CESC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.54 -7.34 -0.41 2.59e-12 Menarche (age at onset); CESC cis rs79349575 0.715 rs55724082 chr17:47017879 G/A cg26022315 chr17:47021804 SNF8 0.39 5.15 0.3 5.01e-7 Type 2 diabetes; CESC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg01341218 chr17:43662625 NA -0.85 -10.53 -0.54 6.95e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1797885 0.934 rs299654 chr3:12550078 A/G cg26432171 chr3:12704882 RAF1 -0.45 -5.66 -0.33 3.94e-8 Immature fraction of reticulocytes; CESC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg24531977 chr5:56204891 C5orf35 -0.87 -10.87 -0.56 5.43e-23 Initial pursuit acceleration; CESC cis rs12413816 0.963 rs12359348 chr10:13765950 C/T cg16485048 chr10:13749193 FRMD4A -0.48 -6.57 -0.37 2.69e-10 Red cell distribution width; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09090048 chr11:134093731 VPS26B;NCAPD3 -0.43 -6.13 -0.35 3.17e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9467711 0.606 rs9379901 chr6:26603866 T/C cg14345882 chr6:26364793 BTN3A2 0.56 5.96 0.34 7.82e-9 Autism spectrum disorder or schizophrenia; CESC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg19622623 chr12:86230825 RASSF9 0.44 5.68 0.33 3.51e-8 Major depressive disorder; CESC cis rs9443645 0.869 rs1507154 chr6:79503700 C/T cg05283184 chr6:79620031 NA -0.44 -6.79 -0.39 7.27e-11 Intelligence (multi-trait analysis); CESC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg22433210 chr17:43662623 NA -0.59 -7.81 -0.43 1.33e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg02569458 chr12:86230093 RASSF9 0.57 8.34 0.46 4.13e-15 Major depressive disorder; CESC cis rs1577917 1.000 rs12207610 chr6:86688016 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -5.57 -0.32 6.1e-8 Response to antipsychotic treatment; CESC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg00166722 chr3:10149974 C3orf24 0.47 5.91 0.34 1.05e-8 Alzheimer's disease; CESC cis rs2415984 0.622 rs61993301 chr14:46949667 C/T cg14871534 chr14:47121158 RPL10L -0.36 -5.37 -0.31 1.75e-7 Number of children ever born; CESC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg01988459 chr11:68622903 NA -0.39 -5.21 -0.3 3.76e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7412746 0.611 rs2256355 chr1:150811794 A/G cg22823121 chr1:150693482 HORMAD1 0.38 5.55 0.32 6.86e-8 Melanoma; CESC cis rs1881797 0.872 rs12404733 chr1:247690417 A/C cg18198730 chr1:247681584 NA 0.57 7.81 0.43 1.32e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs208515 0.525 rs10944859 chr6:66665197 A/G cg07460842 chr6:66804631 NA 0.83 10.33 0.54 3.09e-21 Exhaled nitric oxide levels; CESC cis rs2236918 0.932 rs2488471 chr1:242019831 T/C cg17736920 chr1:242011382 EXO1 0.72 9.08 0.49 2.55e-17 Menopause (age at onset); CESC trans rs877282 0.945 rs71491303 chr10:772884 G/T cg22713356 chr15:30763199 NA 1.12 11.31 0.57 1.87e-24 Uric acid levels; CESC cis rs6089584 0.627 rs13045575 chr20:60565596 G/A cg06108461 chr20:60628389 TAF4 -0.52 -6.87 -0.39 4.7e-11 Body mass index; CESC cis rs2486288 0.656 rs2413774 chr15:45549423 C/T cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs863345 0.604 rs6674656 chr1:158495431 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.87e-11 Pneumococcal bacteremia; CESC cis rs7312933 0.558 rs4768402 chr12:42755576 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.38 -0.36 7.99e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg15664640 chr17:80829946 TBCD 0.49 6.75 0.38 9.17e-11 Breast cancer; CESC cis rs7914558 1.000 rs11191541 chr10:104824199 A/G cg04362960 chr10:104952993 NT5C2 0.47 6.32 0.36 1.11e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9581857 0.579 rs1759861 chr13:27996406 A/C cg01674679 chr13:27998804 GTF3A 0.67 5.55 0.32 6.8e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs12142240 0.698 rs1135460 chr1:46815970 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg07936489 chr17:37558343 FBXL20 -0.8 -11.83 -0.59 3.35e-26 Glomerular filtration rate (creatinine); CESC cis rs6088590 1.000 rs6119530 chr20:33403930 A/G cg24642439 chr20:33292090 TP53INP2 0.86 11.7 0.58 8.76e-26 Coronary artery disease; CESC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg12463550 chr7:65579703 CRCP -0.47 -5.96 -0.34 7.88e-9 Aortic root size; CESC cis rs1707322 0.865 rs785501 chr1:46579611 C/T cg03146154 chr1:46216737 IPP -0.69 -9.13 -0.49 1.84e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs523522 0.962 rs3759394 chr12:120933173 C/A cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg17644776 chr2:200775616 C2orf69 0.54 6.56 0.37 2.76e-10 Osteoporosis; CESC cis rs9911578 1.000 rs7223955 chr17:56917053 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 3.04e-7 Intelligence (multi-trait analysis); CESC cis rs67460515 0.563 rs9883566 chr3:160770323 C/T cg03342759 chr3:160939853 NMD3 0.56 7.17 0.4 7.34e-12 Parkinson's disease; CESC cis rs910316 1.000 rs12589815 chr14:75544101 C/T cg11812906 chr14:75593930 NEK9 0.89 15.06 0.68 1.89e-37 Height; CESC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg25405998 chr7:65216604 CCT6P1 -0.49 -5.4 -0.31 1.48e-7 Aortic root size; CESC cis rs1005277 0.540 rs289638 chr10:37923731 G/A cg25427524 chr10:38739819 LOC399744 -0.62 -8.99 -0.48 4.74e-17 Extrinsic epigenetic age acceleration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14684917 chr11:62380363 EML3;ROM1 -0.5 -7.1 -0.4 1.13e-11 Fibrinogen levels; CESC cis rs4727027 0.631 rs62507511 chr7:148796080 C/A cg23583168 chr7:148888333 NA -0.8 -12.01 -0.59 7.88e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs17431357 1.000 rs73221382 chr12:120917765 T/A cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs761746 0.960 rs5998035 chr22:31939612 G/A cg25791279 chr22:32026902 PISD 0.49 5.59 0.32 5.55e-8 Intelligence; CESC cis rs282587 0.530 rs406997 chr13:113417880 G/C cg02820901 chr13:113351484 ATP11A -0.64 -5.33 -0.31 2.09e-7 Glycated hemoglobin levels; CESC cis rs6460942 1.000 rs75564554 chr7:12319362 A/C cg02935154 chr7:12443704 VWDE -0.59 -5.84 -0.34 1.5e-8 Coronary artery disease; CESC trans rs9467711 0.559 rs6920256 chr6:26537801 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.72 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg13147721 chr7:65941812 NA -0.88 -8.52 -0.46 1.19e-15 Diabetic kidney disease; CESC cis rs9916302 0.898 rs8072297 chr17:37478048 A/T cg00129232 chr17:37814104 STARD3 0.5 6.23 0.36 1.8e-9 Glomerular filtration rate (creatinine); CESC cis rs7481584 0.624 rs449466 chr11:3047603 C/T cg25174290 chr11:3078921 CARS -0.46 -6.4 -0.37 6.86e-10 Calcium levels; CESC cis rs6964587 0.967 rs6970743 chr7:91744311 C/G cg17063962 chr7:91808500 NA 0.57 7.96 0.44 5.03e-14 Breast cancer; CESC cis rs4853525 0.522 rs1860167 chr2:191582387 G/A cg10560079 chr2:191398806 TMEM194B -0.45 -5.54 -0.32 7.12e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; CESC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg11890956 chr21:40555474 PSMG1 1.16 21.17 0.79 6.55e-59 Cognitive function; CESC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg08470875 chr2:26401718 FAM59B -0.75 -7.79 -0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC cis rs4144743 1.000 rs66738981 chr17:45325538 T/A cg18085866 chr17:45331354 ITGB3 -0.61 -6.56 -0.37 2.75e-10 Body mass index; CESC cis rs12136530 0.744 rs16862798 chr1:19777837 A/G cg01832549 chr1:19774989 CAPZB -0.46 -6.78 -0.38 8e-11 Lead levels in blood; CESC cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg00701064 chr4:6280414 WFS1 -0.71 -12.59 -0.61 8.45e-29 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.59 0.38 2.35e-10 Bipolar disorder; CESC cis rs9902453 0.904 rs55633288 chr17:28368196 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.69 -0.47 3.79e-16 Coffee consumption (cups per day); CESC cis rs4450798 0.649 rs6782219 chr3:13779640 A/G cg23332027 chr3:13681764 NA 0.4 5.58 0.32 5.95e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs738322 0.839 rs133015 chr22:38572526 C/G cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.08e-7 Cutaneous nevi; CESC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg22968622 chr17:43663579 NA -1.2 -16.07 -0.7 4.83e-41 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg11764359 chr7:65958608 NA 0.81 11.87 0.59 2.48e-26 Aortic root size; CESC cis rs1401999 0.650 rs3792585 chr3:183646222 A/G cg01324343 chr3:183735012 ABCC5 0.47 9.17 0.49 1.38e-17 Anterior chamber depth; CESC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg01238044 chr22:24384105 GSTT1 -0.55 -6.23 -0.36 1.8e-9 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg00815214 chr21:47717953 NA 0.47 6.34 0.36 9.9e-10 Testicular germ cell tumor; CESC cis rs3820928 0.874 rs10933163 chr2:227815286 A/G cg05526886 chr2:227700861 RHBDD1 -0.39 -5.04 -0.3 8.71e-7 Pulmonary function; CESC cis rs950169 0.922 rs62021167 chr15:85118051 T/A cg17507749 chr15:85114479 UBE2QP1 0.54 6.09 0.35 3.99e-9 Schizophrenia; CESC trans rs11764590 0.724 rs62444917 chr7:2107262 A/C cg11693508 chr17:37793320 STARD3 0.53 6.04 0.35 5.25e-9 Neuroticism; CESC cis rs9796 0.558 rs11855102 chr15:41513257 T/C cg20272979 chr15:41787780 ITPKA 0.34 5.25 0.31 3.18e-7 Menopause (age at onset); CESC cis rs2865126 0.644 rs8098584 chr18:10736934 G/A cg21165219 chr18:10698044 FAM38B -0.53 -5.25 -0.31 3.15e-7 Metabolite levels (5-HIAA/ MHPG Ratio); CESC cis rs10242455 0.557 rs73401516 chr7:99068351 C/A cg18809830 chr7:99032528 PTCD1 -0.59 -5.03 -0.3 9.22e-7 Blood metabolite levels; CESC cis rs698833 0.852 rs4953089 chr2:44565024 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.55 6.91 0.39 3.5e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg16606324 chr3:10149918 C3orf24 0.43 5.22 0.31 3.71e-7 Alzheimer's disease; CESC cis rs2243480 0.708 rs13242216 chr7:65898277 T/C cg13147721 chr7:65941812 NA -0.94 -8.74 -0.47 2.71e-16 Diabetic kidney disease; CESC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11871801 0.918 rs34460267 chr17:40615865 T/C cg21433558 chr17:40837037 CNTNAP1 0.43 5.09 0.3 6.66e-7 Crohn's disease; CESC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg02788857 chr8:22132959 PIWIL2 0.32 5.63 0.33 4.51e-8 Hypertriglyceridemia; CESC cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg17366294 chr4:99064904 C4orf37 0.62 8.59 0.47 7.53e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg04369109 chr6:150039330 LATS1 -0.42 -5.95 -0.34 8.52e-9 Lung cancer; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg23019286 chr1:227728774 NA -0.42 -6.04 -0.35 5.21e-9 Prevalent atrial fibrillation; CESC cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.46 0.46 1.8e-15 Colonoscopy-negative controls vs population controls; CESC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg20887711 chr4:1340912 KIAA1530 0.89 11.87 0.59 2.4e-26 Longevity; CESC trans rs10411161 0.702 rs17778790 chr19:52399559 C/T cg22319618 chr22:45562946 NUP50 -0.75 -7.3 -0.41 3.33e-12 Breast cancer; CESC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.91 0.34 1.03e-8 Tonsillectomy; CESC cis rs9291683 0.546 rs13120348 chr4:10053155 C/G cg11266682 chr4:10021025 SLC2A9 -0.65 -13.09 -0.63 1.61e-30 Bone mineral density; CESC trans rs61931739 0.500 rs7489130 chr12:34539674 C/A cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC cis rs1215050 0.740 rs783916 chr4:99026264 A/C cg17366294 chr4:99064904 C4orf37 -0.48 -6.47 -0.37 4.67e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs6723226 0.804 rs17428810 chr2:32736043 T/C cg02381751 chr2:32503542 YIPF4 -0.82 -11.07 -0.56 1.16e-23 Intelligence (multi-trait analysis); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg17129466 chr19:1848747 REXO1 -0.45 -6.04 -0.35 5.28e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11692369 chr8:54755880 ATP6V1H 0.63 7.63 0.42 4.12e-13 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg12311346 chr5:56204834 C5orf35 0.73 8.93 0.48 7.24e-17 Initial pursuit acceleration; CESC cis rs7648466 0.592 rs2087726 chr3:46208310 G/A cg19145607 chr3:45983792 CXCR6;FYCO1 0.35 5.42 0.32 1.34e-7 Eotaxin levels; CESC cis rs6032067 0.777 rs34343273 chr20:43795293 G/A cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs12477438 0.765 rs12612688 chr2:99613091 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.75 -0.47 2.51e-16 Chronic sinus infection; CESC cis rs75804782 0.521 rs66477197 chr2:239403832 C/T cg18131467 chr2:239335373 ASB1 -0.7 -5.57 -0.32 6.31e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.54 -6.73 -0.38 1.03e-10 Prudent dietary pattern; CESC cis rs8031584 0.918 rs35396566 chr15:31263057 T/C cg08704250 chr15:31115839 NA -0.68 -8.4 -0.46 2.7e-15 Huntington's disease progression; CESC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg18876405 chr7:65276391 NA -0.5 -5.7 -0.33 3.2e-8 Aortic root size; CESC cis rs12497850 0.931 rs4974085 chr3:48924900 C/T cg06212747 chr3:49208901 KLHDC8B 0.62 8.56 0.47 9.56e-16 Parkinson's disease; CESC cis rs67311347 0.866 rs11712426 chr3:40330322 G/A cg24209194 chr3:40518798 ZNF619 0.44 5.58 0.32 6.05e-8 Renal cell carcinoma; CESC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.76 9.76 0.51 2.06e-19 Height; CESC cis rs9815354 0.680 rs73075231 chr3:42051694 T/C cg03022575 chr3:42003672 ULK4 0.78 6.65 0.38 1.67e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs7662987 0.517 rs2602858 chr4:100030461 T/C cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC trans rs13160161 0.533 rs17364997 chr5:39054742 C/G cg09550024 chr10:96698366 CYP2C9 -0.46 -6.22 -0.36 1.98e-9 Obesity-related traits; CESC cis rs3026101 0.647 rs12603729 chr17:5320685 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.59 0.32 5.61e-8 Body mass index; CESC cis rs6541297 0.715 rs4846840 chr1:230302521 A/C cg20703242 chr1:230279135 GALNT2 0.37 5.74 0.33 2.52e-8 Coronary artery disease; CESC cis rs9487051 0.676 rs7775206 chr6:109597222 A/G cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19935506 chr2:242626874 DTYMK 0.46 6.41 0.37 6.66e-10 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs1120708 chr4:98931260 G/C cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9815354 0.951 rs9850310 chr3:41891098 T/C cg03022575 chr3:42003672 ULK4 0.58 5.94 0.34 9.04e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06474646 chr7:128864675 AHCYL2 0.55 6.14 0.35 2.94e-9 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03665832 chr7:98923565 ARPC1A -0.47 -6.36 -0.36 9.05e-10 Ulcerative colitis; CESC cis rs6912958 0.712 rs9444526 chr6:88326402 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -5.41 -0.32 1.39e-7 Monocyte percentage of white cells; CESC cis rs4253772 0.550 rs55926596 chr22:46682955 C/T cg24881330 chr22:46731750 TRMU 0.82 6.07 0.35 4.41e-9 LDL cholesterol;Cholesterol, total; CESC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg22907277 chr7:1156413 C7orf50 0.45 6.43 0.37 6.07e-10 Longevity;Endometriosis; CESC cis rs483180 0.531 rs662243 chr1:120209564 A/C cg19096424 chr1:120255104 PHGDH 0.43 5.21 0.3 3.78e-7 Macular telangiectasia type 2; CESC cis rs9790314 0.967 rs339101 chr3:161064193 A/T cg03342759 chr3:160939853 NMD3 -0.45 -5.92 -0.34 1.02e-8 Morning vs. evening chronotype; CESC cis rs754466 0.651 rs11002322 chr10:79649653 G/T cg17075019 chr10:79541650 NA -0.83 -12.12 -0.6 3.4e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg06784218 chr1:46089804 CCDC17 -0.3 -5.11 -0.3 6.3e-7 High light scatter reticulocyte count; CESC cis rs1729951 0.575 rs10935214 chr3:136693485 G/A cg03617693 chr3:136751559 NA 0.39 5.38 0.31 1.68e-7 Neuroticism; CESC cis rs9314323 0.767 rs1865305 chr8:26233325 G/A cg13160058 chr8:26243215 BNIP3L -0.32 -5.14 -0.3 5.31e-7 Red cell distribution width; CESC cis rs12142240 0.698 rs41293273 chr1:46806393 T/C cg00530320 chr1:46809349 NSUN4 0.59 7.85 0.43 1.02e-13 Menopause (age at onset); CESC cis rs6088580 0.634 rs6059860 chr20:33063830 A/C cg06115741 chr20:33292138 TP53INP2 0.47 6.08 0.35 4.22e-9 Glomerular filtration rate (creatinine); CESC cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg10556349 chr10:835070 NA 0.52 5.03 0.3 9.17e-7 Eosinophil percentage of granulocytes; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg20104688 chr17:76183078 TK1;AFMID 0.62 6.2 0.36 2.17e-9 Diastolic blood pressure; CESC cis rs4253772 0.550 rs6008598 chr22:46704243 C/T cg18190219 chr22:46762943 CELSR1 -0.55 -6.14 -0.35 3.08e-9 LDL cholesterol;Cholesterol, total; CESC trans rs459571 0.959 rs408307 chr9:136892523 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.55 7.32 0.41 3.04e-12 Platelet distribution width; CESC cis rs1707322 1.000 rs10890355 chr1:46317348 G/A cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9902453 0.933 rs7221154 chr17:28505024 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -7.33 -0.41 2.77e-12 Coffee consumption (cups per day); CESC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg14393609 chr7:65229607 NA -0.47 -6.32 -0.36 1.08e-9 Aortic root size; CESC cis rs9913156 0.707 rs9902000 chr17:4582426 A/C cg19197139 chr17:4613644 ARRB2 -0.81 -9.47 -0.5 1.6e-18 Lymphocyte counts; CESC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.65e-39 Menopause (age at onset); CESC cis rs8017423 0.967 rs12589808 chr14:90719236 C/T cg14092571 chr14:90743983 NA 0.57 8.67 0.47 4.43e-16 Mortality in heart failure; CESC cis rs2197308 0.765 rs68029712 chr12:37906585 T/G cg13010199 chr12:38710504 ALG10B 0.53 6.75 0.38 9.06e-11 Morning vs. evening chronotype; CESC trans rs17685 0.753 rs10952840 chr7:75772878 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 12.42 0.61 3.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs2191566 0.664 rs8105574 chr19:44589042 T/C cg20607764 chr19:44506953 ZNF230 -0.4 -5.31 -0.31 2.33e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs10242455 0.571 rs13438288 chr7:98916414 T/G cg25640893 chr7:99214727 ZNF498 0.88 5.93 0.34 9.63e-9 Blood metabolite levels; CESC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg07343612 chr16:622815 PIGQ -0.54 -7.87 -0.44 9.33e-14 Height; CESC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg11766577 chr21:47581405 C21orf56 -0.48 -6.58 -0.37 2.56e-10 Testicular germ cell tumor; CESC cis rs10504073 0.584 rs55838473 chr8:49948281 C/A cg00325661 chr8:49890786 NA 0.57 8.57 0.47 8.91e-16 Blood metabolite ratios; CESC cis rs3091242 0.902 rs36003018 chr1:25784318 A/G cg27572855 chr1:25598939 RHD -0.43 -7.22 -0.41 5.47e-12 Erythrocyte sedimentation rate; CESC trans rs9929218 0.953 rs9927329 chr16:68750331 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -10.42 -0.54 1.52e-21 Colorectal cancer; CESC cis rs1697139 0.583 rs6895853 chr5:66541427 T/C cg11553311 chr5:66541588 NA 0.39 5.47 0.32 1.04e-7 Breast cancer; CESC cis rs7605827 0.930 rs11896745 chr2:15515373 C/T cg19274914 chr2:15703543 NA 0.32 5.7 0.33 3.17e-8 Educational attainment (years of education); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15441230 chr15:44069583 ELL3 -0.48 -6.56 -0.37 2.76e-10 Fibrinogen levels; CESC cis rs7254114 0.578 rs35248735 chr19:11312238 G/A cg02815516 chr19:11306319 KANK2 -0.44 -7.18 -0.4 7.21e-12 Immature fraction of reticulocytes; CESC trans rs561341 1.000 rs2470243 chr17:30290955 C/T cg20587970 chr11:113659929 NA -1.48 -19.48 -0.77 4.55e-53 Hip circumference adjusted for BMI; CESC cis rs11785400 1.000 rs4736368 chr8:143748528 G/C cg24634471 chr8:143751801 JRK 0.47 6.13 0.35 3.09e-9 Schizophrenia; CESC cis rs2204008 0.837 rs11172728 chr12:38070042 C/A cg26384229 chr12:38710491 ALG10B 0.67 9.33 0.5 4.5e-18 Bladder cancer; CESC cis rs28374715 0.617 rs16971735 chr15:41563970 C/G cg18705301 chr15:41695430 NDUFAF1 -0.51 -7.35 -0.41 2.44e-12 Ulcerative colitis; CESC trans rs2658782 0.756 rs3019223 chr11:93084182 G/A cg03479527 chr8:145637966 SLC39A4 -0.41 -6.0 -0.35 6.35e-9 Pulmonary function decline; CESC cis rs897984 0.806 rs4889571 chr16:30949047 A/G cg00531865 chr16:30841666 NA 0.51 7.01 0.4 1.99e-11 Dementia with Lewy bodies; CESC cis rs950027 0.620 rs1617634 chr15:45615578 A/G cg21132104 chr15:45694354 SPATA5L1 0.66 8.52 0.46 1.22e-15 Response to fenofibrate (adiponectin levels); CESC cis rs826838 0.804 rs6580755 chr12:39159190 C/T cg26384229 chr12:38710491 ALG10B 0.79 13.41 0.64 1.19e-31 Heart rate; CESC cis rs56104184 0.830 rs17272645 chr19:49342366 C/G cg15549821 chr19:49342101 PLEKHA4 0.86 11.06 0.56 1.26e-23 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs6775745 0.654 rs9840453 chr3:131777465 G/T cg12213930 chr3:131751605 CPNE4 0.49 5.56 0.32 6.63e-8 Neutrophil count; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg24415082 chr16:74700811 RFWD3 -0.58 -6.4 -0.37 7.11e-10 Subjective well-being; CESC cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg23711669 chr6:146136114 FBXO30 -0.89 -11.81 -0.59 3.86e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs1707322 0.821 rs11211182 chr1:46240170 G/A cg06784218 chr1:46089804 CCDC17 0.37 6.24 0.36 1.73e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9905704 0.647 rs3809723 chr17:57061978 T/G cg12560992 chr17:57184187 TRIM37 0.63 7.87 0.44 9.22e-14 Testicular germ cell tumor; CESC cis rs35955747 0.689 rs5997988 chr22:31838085 G/A cg25791279 chr22:32026902 PISD -0.44 -5.21 -0.3 3.8e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs1163251 0.869 rs487884 chr1:120217330 C/T cg19096424 chr1:120255104 PHGDH 0.43 5.22 0.31 3.62e-7 Blood metabolite levels; CESC cis rs10744422 1.000 rs937766 chr12:123331094 G/T cg25930673 chr12:123319894 HIP1R -0.72 -5.73 -0.33 2.79e-8 Schizophrenia; CESC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.26 0.31 3.02e-7 Tonsillectomy; CESC cis rs4253772 0.745 rs78023664 chr22:46647844 G/A cg18190219 chr22:46762943 CELSR1 -0.69 -6.19 -0.36 2.26e-9 LDL cholesterol;Cholesterol, total; CESC cis rs4803455 0.565 rs1025497 chr19:41871254 A/G cg09537434 chr19:41945824 ATP5SL -0.69 -9.86 -0.52 9.56e-20 Migraine;Coronary artery disease; CESC cis rs2243480 1.000 rs6966322 chr7:65646754 A/G cg13147721 chr7:65941812 NA 0.97 9.16 0.49 1.47e-17 Diabetic kidney disease; CESC cis rs35146811 0.555 rs2525539 chr7:99545309 A/G cg22531904 chr7:99595276 NA 0.41 5.23 0.31 3.53e-7 Coronary artery disease; CESC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.96e-12 Major depressive disorder; CESC cis rs61931739 0.500 rs6488209 chr12:34319309 A/G cg06521331 chr12:34319734 NA -0.45 -6.26 -0.36 1.57e-9 Morning vs. evening chronotype; CESC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg22920501 chr2:26401640 FAM59B 0.86 9.81 0.52 1.37e-19 Gut microbiome composition (summer); CESC cis rs7772486 0.754 rs9497434 chr6:146260753 C/T cg05347473 chr6:146136440 FBXO30 -0.57 -7.26 -0.41 4.32e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs13082711 0.834 rs2840088 chr3:27428371 G/A cg02860705 chr3:27208620 NA 0.56 6.89 0.39 4.13e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs17125944 0.505 rs75296244 chr14:53233218 G/A cg00686598 chr14:53173677 PSMC6 1.4 11.75 0.59 6.26e-26 Alzheimer's disease (late onset); CESC cis rs5758659 0.652 rs133326 chr22:42406885 G/A cg04733989 chr22:42467013 NAGA 0.44 5.86 0.34 1.35e-8 Cognitive function; CESC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg24531977 chr5:56204891 C5orf35 0.87 11.1 0.56 9.48e-24 Initial pursuit acceleration; CESC cis rs17641971 0.684 rs1876717 chr8:49994968 T/G cg00325661 chr8:49890786 NA 0.39 5.49 0.32 9.18e-8 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12149841 chr12:121124893 MLEC -0.7 -8.46 -0.46 1.8e-15 Gut microbiome composition (summer); CESC cis rs3096299 0.728 rs1011749 chr16:89510869 G/C cg16743903 chr16:89593216 SPG7 -0.42 -5.5 -0.32 9.07e-8 Multiple myeloma (IgH translocation); CESC cis rs863345 0.967 rs10797017 chr1:158468485 G/A cg12129480 chr1:158549410 OR10X1 -0.31 -6.23 -0.36 1.78e-9 Pneumococcal bacteremia; CESC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg07936489 chr17:37558343 FBXL20 -0.79 -10.78 -0.55 1.03e-22 Glomerular filtration rate (creatinine); CESC cis rs73206853 0.764 rs12311093 chr12:110978032 A/G cg12870014 chr12:110450643 ANKRD13A -0.73 -7.62 -0.42 4.48e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9549367 0.713 rs11620600 chr13:113829090 G/A cg00898013 chr13:113819073 PROZ -0.56 -7.77 -0.43 1.77e-13 Platelet distribution width; CESC cis rs7474896 0.515 rs2749582 chr10:38275284 A/G cg00409905 chr10:38381863 ZNF37A 0.45 5.06 0.3 7.68e-7 Obesity (extreme); CESC cis rs7264396 1.000 rs7264396 chr20:34154741 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.52 6.11 0.35 3.46e-9 Total cholesterol levels; CESC cis rs854765 0.583 rs12452219 chr17:17829423 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.52 7.22 0.41 5.4e-12 Total body bone mineral density; CESC cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.88 13.54 0.64 4.12e-32 Prudent dietary pattern; CESC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg22920501 chr2:26401640 FAM59B 0.91 10.33 0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg22920501 chr2:26401640 FAM59B 0.64 7.7 0.43 2.68e-13 Gut microbiome composition (summer); CESC cis rs9910055 0.530 rs2269906 chr17:42294337 G/T cg19774624 chr17:42201019 HDAC5 0.61 8.75 0.47 2.55e-16 Total body bone mineral density; CESC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg12756686 chr19:29218302 NA 0.53 7.09 0.4 1.18e-11 Methadone dose in opioid dependence; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01517273 chr1:154599968 ADAR -0.46 -6.01 -0.35 5.95e-9 Height; CESC cis rs7927771 0.524 rs2290851 chr11:47753370 C/T cg05585544 chr11:47624801 NA -0.32 -5.11 -0.3 6.24e-7 Subjective well-being; CESC cis rs9788682 0.694 rs10851906 chr15:78774676 A/G cg24631222 chr15:78858424 CHRNA5 0.65 7.69 0.43 2.83e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs11719291 0.915 rs11557629 chr3:48732223 G/A cg03060546 chr3:49711283 APEH -0.61 -5.03 -0.3 9.02e-7 Cognitive function; CESC cis rs959260 0.557 rs4788887 chr17:73323876 C/G cg12999837 chr17:73267436 MIF4GD -0.43 -5.16 -0.3 4.89e-7 Systemic lupus erythematosus; CESC cis rs2304069 0.526 rs6863283 chr5:149402448 C/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.46 6.26 0.36 1.5e-9 HIV-1 control; CESC cis rs3096299 0.933 rs2965938 chr16:89491336 C/T cg08392591 chr16:89556376 ANKRD11 0.44 5.73 0.33 2.7e-8 Multiple myeloma (IgH translocation); CESC cis rs72792276 0.818 rs57249773 chr5:127463166 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.66 5.26 0.31 3.04e-7 Red cell distribution width; CESC cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg14416269 chr4:6271139 WFS1 0.46 7.73 0.43 2.27e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 9.72 0.51 2.72e-19 Prudent dietary pattern; CESC cis rs4722166 0.645 rs1404006 chr7:22795077 T/C cg05472934 chr7:22766657 IL6 0.64 8.44 0.46 2.08e-15 Lung cancer; CESC trans rs11678036 1.000 rs11678036 chr2:186024735 A/G cg21136544 chr6:3160547 NA 0.36 6.59 0.38 2.3e-10 IgG glycosylation; CESC cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs258892 0.895 rs2338793 chr5:72073172 T/G cg21869765 chr5:72125136 TNPO1 -0.38 -5.2 -0.3 3.94e-7 Small cell lung carcinoma; CESC cis rs7219021 0.961 rs3901705 chr17:46865760 T/C cg16584676 chr17:46985605 UBE2Z -0.73 -8.25 -0.45 7.64e-15 Schizophrenia or bipolar disorder; CESC cis rs10206020 0.836 rs10202105 chr2:1553301 C/T cg01028140 chr2:1542097 TPO -0.43 -5.24 -0.31 3.2e-7 IgG glycosylation; CESC cis rs4975616 0.869 rs465498 chr5:1325803 A/G cg26373071 chr5:1325741 CLPTM1L 0.43 7.03 0.4 1.71e-11 Lung cancer; CESC cis rs6460942 0.630 rs17670901 chr7:12386622 G/A cg06484146 chr7:12443880 VWDE -0.62 -6.76 -0.38 8.87e-11 Coronary artery disease; CESC cis rs7143963 0.609 rs11846158 chr14:103292959 A/G cg24154132 chr14:103367632 TRAF3 0.34 6.31 0.36 1.18e-9 Body mass index; CESC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg12463550 chr7:65579703 CRCP -0.49 -6.27 -0.36 1.43e-9 Aortic root size; CESC cis rs9583531 0.689 rs6492308 chr13:111377829 T/C cg24331049 chr13:111365604 ING1 0.72 10.36 0.54 2.39e-21 Coronary artery disease; CESC cis rs1580019 0.563 rs34319173 chr7:32585904 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.07 18.36 0.75 3.97e-49 Cognitive ability; CESC cis rs35110281 0.782 rs9981790 chr21:45045052 G/C cg01579765 chr21:45077557 HSF2BP -0.57 -9.92 -0.52 6.23e-20 Mean corpuscular volume; CESC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg16545954 chr1:2118288 C1orf86 0.35 6.55 0.37 2.95e-10 Height; CESC cis rs10924309 0.737 rs4658797 chr1:245854862 G/A cg00036263 chr1:245852353 KIF26B -0.54 -7.18 -0.4 7.12e-12 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs9858542 0.953 rs6803222 chr3:49665976 T/G cg03060546 chr3:49711283 APEH -0.57 -6.68 -0.38 1.42e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6582630 0.555 rs10748382 chr12:38504529 C/T cg26384229 chr12:38710491 ALG10B 0.68 10.17 0.53 1.02e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs7647973 0.592 rs6774202 chr3:49687779 T/G cg06212747 chr3:49208901 KLHDC8B 0.66 8.11 0.45 1.84e-14 Menarche (age at onset); CESC cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg02574844 chr11:5959923 NA -0.41 -5.08 -0.3 6.96e-7 DNA methylation (variation); CESC cis rs1003719 0.680 rs8130069 chr21:38552116 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.68e-15 Eye color traits; CESC cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg05340658 chr4:99064831 C4orf37 0.84 12.81 0.62 1.45e-29 Colonoscopy-negative controls vs population controls; CESC cis rs4803468 0.967 rs13345590 chr19:41886455 T/G cg09537434 chr19:41945824 ATP5SL -1.02 -18.22 -0.75 1.23e-48 Height; CESC trans rs1814175 0.904 rs7924371 chr11:49620595 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -17.77 -0.74 4.61e-47 Height; CESC cis rs12477438 0.572 rs10170063 chr2:99655639 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC trans rs9951602 0.512 rs4799246 chr18:76653417 A/G cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs2933343 0.679 rs1091938 chr3:128637025 T/C cg24203234 chr3:128598194 ACAD9 0.4 5.26 0.31 3.01e-7 IgG glycosylation; CESC cis rs35110281 0.837 rs2838336 chr21:45071741 A/G cg21573476 chr21:45109991 RRP1B 0.47 6.69 0.38 1.3100000000000001e-10 Mean corpuscular volume; CESC cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg21699342 chr2:239360505 ASB1 0.41 5.72 0.33 2.92e-8 Multiple system atrophy; CESC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg04369109 chr6:150039330 LATS1 -0.38 -5.29 -0.31 2.58e-7 Lung cancer; CESC cis rs67072384 0.818 rs1872127 chr11:72465085 G/A cg04827223 chr11:72435913 ARAP1 -0.7 -7.1 -0.4 1.16e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs113835537 0.877 rs57127845 chr11:66318325 C/T cg24851651 chr11:66362959 CCS 0.61 5.48 0.32 9.88e-8 Airway imaging phenotypes; CESC cis rs947211 0.750 rs5014255 chr1:205753870 C/A cg26354017 chr1:205819088 PM20D1 0.41 5.14 0.3 5.41e-7 Parkinson's disease; CESC cis rs9911578 0.692 rs411988 chr17:56709034 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.42 5.67 0.33 3.82e-8 Intelligence (multi-trait analysis); CESC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg23982607 chr1:1823379 GNB1 -0.78 -12.63 -0.61 6.1e-29 Body mass index; CESC cis rs6831352 0.879 rs56295995 chr4:100060899 C/T cg13256891 chr4:100009986 ADH5 -0.75 -8.21 -0.45 9.89e-15 Alcohol dependence; CESC cis rs2635047 0.967 rs7242978 chr18:44633424 G/T cg19077165 chr18:44547161 KATNAL2 0.46 6.26 0.36 1.52e-9 Educational attainment; CESC cis rs1949733 0.523 rs16842557 chr4:8543985 C/T cg11789530 chr4:8429930 ACOX3 -0.58 -7.26 -0.41 4.33e-12 Response to antineoplastic agents; CESC cis rs7917772 0.629 rs1475646 chr10:104522564 G/T cg04362960 chr10:104952993 NT5C2 0.44 5.1 0.3 6.41e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9733 0.744 rs3754211 chr1:150951857 G/A cg13175981 chr1:150552382 MCL1 -0.42 -5.47 -0.32 1.06e-7 Tonsillectomy; CESC cis rs7246865 0.510 rs11086051 chr19:17168590 A/G cg16202187 chr19:17186497 HAUS8;MYO9B 0.51 6.72 0.38 1.13e-10 Reticulocyte fraction of red cells; CESC trans rs17508449 0.819 rs17031795 chr1:114255828 T/C cg23028848 chr11:57092561 TNKS1BP1 -0.76 -6.14 -0.35 2.99e-9 Leprosy; CESC cis rs6938 0.618 rs2044157 chr15:75225808 G/C cg09165964 chr15:75287851 SCAMP5 0.49 6.64 0.38 1.81e-10 Breast cancer; CESC trans rs1116547 0.571 rs73242809 chr5:112898437 T/C cg10115368 chr14:100435663 NA 0.5 6.1 0.35 3.72e-9 Cerebral amyloid angiopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08105951 chr7:5229733 WIPI2 0.52 6.02 0.35 5.67e-9 Gut microbiome composition (summer); CESC cis rs2637266 0.818 rs7894799 chr10:78392012 T/C cg18941641 chr10:78392320 NA 0.41 7.52 0.42 8.61e-13 Pulmonary function; CESC cis rs9894429 0.690 rs12949956 chr17:79542813 C/T cg21984481 chr17:79567631 NPLOC4 0.56 9.14 0.49 1.63e-17 Eye color traits; CESC cis rs11098499 0.909 rs11723839 chr4:120299673 G/A cg24375607 chr4:120327624 NA 0.46 5.58 0.32 5.79e-8 Corneal astigmatism; CESC cis rs2243480 1.000 rs6974723 chr7:65637939 C/T cg13147721 chr7:65941812 NA 0.97 9.19 0.49 1.2e-17 Diabetic kidney disease; CESC cis rs9611565 0.765 rs132908 chr22:41801795 G/A cg06634786 chr22:41940651 POLR3H 0.73 7.47 0.42 1.2e-12 Vitiligo; CESC cis rs2273669 0.667 rs12196010 chr6:109302173 C/A cg05315195 chr6:109294784 ARMC2 -0.65 -5.82 -0.34 1.71e-8 Prostate cancer; CESC cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -7.6 -0.42 5.23e-13 Alzheimer's disease; CESC cis rs6714710 0.603 rs58546246 chr2:98521823 C/A cg26665480 chr2:98280029 ACTR1B 0.57 7.99 0.44 4.15e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs2777491 0.915 rs7178777 chr15:41634588 C/A cg18705301 chr15:41695430 NDUFAF1 -0.6 -9.0 -0.48 4.34e-17 Ulcerative colitis; CESC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg05255149 chr17:80675120 FN3KRP 0.47 5.35 0.31 1.9e-7 Glycated hemoglobin levels; CESC cis rs4074961 0.692 rs11264075 chr1:38083941 C/G cg13401533 chr1:37979913 MEAF6 0.5 6.66 0.38 1.59e-10 Axial length; CESC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg12311346 chr5:56204834 C5orf35 -0.64 -7.96 -0.44 4.98e-14 Initial pursuit acceleration; CESC cis rs9900062 0.771 rs9909152 chr17:62719475 G/A cg02598441 chr17:62777298 LOC146880 -0.67 -7.9 -0.44 7.57e-14 QT interval; CESC cis rs6541297 0.699 rs12065546 chr1:230295245 C/T cg20703242 chr1:230279135 GALNT2 0.6 6.81 0.39 6.49e-11 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04414295 chr14:102606318 WDR20;HSP90AA1 0.62 7.36 0.41 2.25e-12 Gut microbiome composition (summer); CESC trans rs10489896 0.541 rs6693478 chr1:234593403 T/C cg23817893 chr11:86085932 CCDC81 -0.45 -6.2 -0.36 2.14e-9 Cognitive test performance; CESC cis rs55794721 0.509 rs12027110 chr1:25775682 A/T cg02931644 chr1:25747376 RHCE 0.46 7.99 0.44 4.15e-14 Plateletcrit;Mean corpuscular volume; CESC cis rs9372253 1.000 rs11153232 chr6:110716252 G/T cg19196401 chr6:110721138 DDO 0.37 5.37 0.31 1.72e-7 Platelet distribution width; CESC cis rs2243480 0.708 rs781141 chr7:65438553 A/G cg12463550 chr7:65579703 CRCP 0.68 5.63 0.33 4.55e-8 Diabetic kidney disease; CESC cis rs9300255 0.596 rs1568427 chr12:123738678 A/G cg05973401 chr12:123451056 ABCB9 0.45 5.45 0.32 1.15e-7 Neutrophil percentage of white cells; CESC cis rs763121 0.853 rs6519119 chr22:38989007 C/G cg06022373 chr22:39101656 GTPBP1 0.84 12.27 0.6 1.07e-27 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08058591 chr19:40708324 MAP3K10 -0.57 -6.72 -0.38 1.1e-10 Gut microbiome composition (summer); CESC cis rs9807989 0.571 rs10208293 chr2:102966310 G/A cg09003973 chr2:102972529 NA 0.53 5.32 0.31 2.25e-7 Asthma; CESC cis rs2637266 0.935 rs12414653 chr10:78394071 C/G cg18941641 chr10:78392320 NA 0.45 8.39 0.46 2.93e-15 Pulmonary function; CESC trans rs1728785 1.000 rs698719 chr16:68560125 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.26 0.41 4.42e-12 Ulcerative colitis; CESC cis rs4268898 0.552 rs6754391 chr2:24369019 C/T cg20701182 chr2:24300061 SF3B14 0.4 5.48 0.32 1e-7 Asthma; CESC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg18876405 chr7:65276391 NA -0.49 -6.83 -0.39 5.72e-11 Aortic root size; CESC cis rs8114671 0.773 rs3746438 chr20:33584289 C/T cg07148914 chr20:33460835 GGT7 -0.39 -5.12 -0.3 5.78e-7 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12640387 chr1:6694331 THAP3;DNAJC11 0.49 6.91 0.39 3.63e-11 Fibrinogen levels; CESC trans rs7726839 0.574 rs11134148 chr5:637107 C/T cg25482853 chr8:67687455 SGK3 1.01 10.03 0.52 2.86e-20 Obesity-related traits; CESC cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg18904891 chr8:8559673 CLDN23 -0.45 -5.49 -0.32 9.25e-8 Mood instability; CESC cis rs9457247 1.000 rs422780 chr6:167406209 A/G cg07741184 chr6:167504864 NA 0.29 5.31 0.31 2.32e-7 Crohn's disease; CESC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg02569458 chr12:86230093 RASSF9 0.48 7.11 0.4 1.07e-11 Major depressive disorder; CESC cis rs11997175 0.624 rs10435522 chr8:33698608 G/A ch.8.33884649F chr8:33765107 NA 0.5 6.27 0.36 1.46e-9 Body mass index; CESC cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg11366901 chr6:160182831 ACAT2 0.8 9.87 0.52 9.36e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.54 0.81 1.53e-63 Prudent dietary pattern; CESC cis rs7078219 0.505 rs7077040 chr10:101281014 C/G cg09788492 chr10:101292477 NKX2-3 0.33 6.16 0.35 2.75e-9 Dental caries; CESC cis rs7647973 0.626 rs9824435 chr3:49674343 A/G cg03060546 chr3:49711283 APEH -0.67 -7.26 -0.41 4.19e-12 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04536951 chr19:9268775 ZNF317 -0.6 -6.48 -0.37 4.5e-10 Gut microbiome composition (summer); CESC cis rs1624802 0.841 rs78426981 chr12:130497782 A/G cg15444478 chr12:130494697 NA -0.28 -5.16 -0.3 4.77e-7 Obesity-related traits; CESC cis rs6736093 0.796 rs4848971 chr2:112790446 C/T cg12686935 chr2:112915763 FBLN7 -0.41 -5.45 -0.32 1.13e-7 Coronary artery disease; CESC cis rs1801251 0.727 rs6437071 chr2:233568793 G/A cg25237894 chr2:233734115 C2orf82 0.38 6.5 0.37 3.93e-10 Coronary artery disease; CESC cis rs6754311 0.551 rs10928545 chr2:136501840 A/G cg07169764 chr2:136633963 MCM6 -0.74 -9.42 -0.5 2.37e-18 Mosquito bite size; CESC cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg00080972 chr5:178986291 RUFY1 0.44 6.98 0.39 2.35e-11 Lung cancer; CESC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg17971929 chr21:40555470 PSMG1 -0.6 -7.91 -0.44 7.15e-14 Menarche (age at onset); CESC cis rs965469 0.779 rs967366 chr20:3266935 T/G cg25506879 chr20:3388711 C20orf194 -0.47 -5.23 -0.31 3.4e-7 IFN-related cytopenia; CESC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.86 0.34 1.4e-8 Electroencephalogram traits; CESC cis rs7605827 0.930 rs13002869 chr2:15674389 C/T cg19274914 chr2:15703543 NA 0.38 6.79 0.38 7.31e-11 Educational attainment (years of education); CESC cis rs17253792 0.749 rs17747301 chr14:56125030 C/G cg01858014 chr14:56050164 KTN1 -0.98 -7.75 -0.43 1.97e-13 Putamen volume; CESC cis rs66530629 0.874 rs4648878 chr1:25164113 A/G cg22509179 chr1:25234806 RUNX3 -0.42 -5.58 -0.32 6.02e-8 Plateletcrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20448447 chr12:122255296 SETD1B -0.5 -6.04 -0.35 5.3e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.550 rs6008729 chr22:46727428 C/G cg18190219 chr22:46762943 CELSR1 0.47 6.1 0.35 3.77e-9 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07354253 chr5:131629923 SLC22A4 0.58 6.8 0.39 6.85e-11 Gut microbiome composition (summer); CESC cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg26597838 chr10:835615 NA 0.86 8.99 0.48 4.68e-17 Eosinophil percentage of granulocytes; CESC cis rs2882667 0.858 rs11959851 chr5:138421405 C/G cg04439458 chr5:138467593 SIL1 -0.34 -5.24 -0.31 3.31e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4985726 0.702 rs12603708 chr17:16847113 C/T cg22251401 chr17:16590232 NA 0.4 5.3 0.31 2.43e-7 Non-albumin protein levels; CESC cis rs2749592 0.513 rs9417249 chr10:37837155 C/T cg25427524 chr10:38739819 LOC399744 0.41 5.36 0.31 1.84e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Parkinson's disease; CESC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.5e-8 Developmental language disorder (linguistic errors); CESC cis rs10779751 1.000 rs4845858 chr1:11304720 C/T cg08854313 chr1:11322531 MTOR 0.92 14.42 0.66 3.5e-35 Body mass index; CESC cis rs7927771 0.507 rs11039432 chr11:47873327 G/A cg18512352 chr11:47633146 NA 0.34 5.23 0.31 3.39e-7 Subjective well-being; CESC cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.8 -12.62 -0.61 6.61e-29 Hip circumference adjusted for BMI; CESC cis rs2228479 0.850 rs62052714 chr16:89857180 T/C cg14709524 chr16:89940631 TCF25 0.94 7.06 0.4 1.5e-11 Skin colour saturation; CESC cis rs17253792 0.545 rs34446601 chr14:56010586 A/G cg01858014 chr14:56050164 KTN1 -0.87 -6.66 -0.38 1.56e-10 Putamen volume; CESC cis rs7605827 0.930 rs11900088 chr2:15613994 T/C cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.61 0.64 2.42e-32 Prudent dietary pattern; CESC cis rs8050907 0.744 rs7194436 chr16:4539832 G/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.89 6.22 0.36 1.94e-9 Obesity-related traits; CESC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -5.99 -0.35 6.68e-9 Cystic fibrosis severity; CESC cis rs72901758 0.696 rs72909029 chr17:76249451 A/G cg25512537 chr17:76250053 NA 0.4 5.47 0.32 1.02e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg18252515 chr7:66147081 NA -0.43 -5.59 -0.32 5.73e-8 Aortic root size; CESC cis rs6912958 0.781 rs3934838 chr6:88284699 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.58 -0.37 2.55e-10 Monocyte percentage of white cells; CESC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.78 0.33 2.14e-8 Electroencephalogram traits; CESC cis rs113835537 0.529 rs11227514 chr11:66286627 G/A cg22134325 chr11:66188745 NPAS4 0.35 5.59 0.32 5.52e-8 Airway imaging phenotypes; CESC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg18225595 chr11:63971243 STIP1 0.51 5.28 0.31 2.69e-7 Mean platelet volume; CESC cis rs367943 1.000 rs348929 chr5:112814883 T/A cg12552261 chr5:112820674 MCC -0.62 -7.72 -0.43 2.34e-13 Type 2 diabetes; CESC cis rs854765 0.693 rs9907246 chr17:17770965 T/C cg09796270 chr17:17721594 SREBF1 -0.45 -6.36 -0.36 8.61e-10 Total body bone mineral density; CESC cis rs7084402 0.967 rs1658422 chr10:60331758 G/T cg07615347 chr10:60278583 BICC1 0.59 9.15 0.49 1.57e-17 Refractive error; CESC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg24675658 chr1:53192096 ZYG11B -0.57 -6.98 -0.39 2.37e-11 Monocyte count; CESC cis rs71403859 0.502 rs75986475 chr16:71464058 C/G cg08717414 chr16:71523259 ZNF19 -0.86 -8.17 -0.45 1.25e-14 Post bronchodilator FEV1; CESC cis rs59698941 0.943 rs67422135 chr5:132222728 T/A cg02081065 chr5:132209139 LEAP2 -0.52 -5.11 -0.3 6.08e-7 Apolipoprotein A-IV levels; CESC cis rs7264396 0.836 rs961020 chr20:34182069 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.8 -0.39 7.02e-11 Total cholesterol levels; CESC cis rs8072100 0.512 rs9674670 chr17:45386157 G/A cg25173405 chr17:45401733 C17orf57 -0.41 -5.34 -0.31 2.04e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9303280 0.776 rs9910826 chr17:38035648 A/G cg20243544 chr17:37824526 PNMT 0.5 6.54 0.37 3.21e-10 Self-reported allergy; CESC cis rs6991838 0.584 rs1533285 chr8:66549364 T/C cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15550435 chr10:92979939 PCGF5 -0.52 -6.06 -0.35 4.62e-9 Gut microbiome composition (summer); CESC cis rs4604732 0.631 rs34924545 chr1:247626892 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.56 6.94 0.39 2.97e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11098499 0.779 rs10011097 chr4:120310359 T/G cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14949694 chr7:66367000 NA -0.6 -6.52 -0.37 3.54e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16444294 chr16:28925790 RABEP2 -0.57 -6.73 -0.38 1.03e-10 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg10691866 chr7:65817282 TPST1 -0.36 -5.83 -0.34 1.58e-8 Aortic root size; CESC cis rs9815354 0.680 rs73073239 chr3:42014597 G/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.78e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs826838 1.000 rs11168217 chr12:38884278 T/C cg13010199 chr12:38710504 ALG10B 0.6 8.51 0.46 1.26e-15 Heart rate; CESC trans rs459571 0.839 rs2519831 chr9:136886257 T/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.63 -8.08 -0.44 2.31e-14 Platelet distribution width; CESC cis rs1499614 1.000 rs2141924 chr7:66186246 C/T cg12463550 chr7:65579703 CRCP 0.73 5.73 0.33 2.78e-8 Gout; CESC cis rs637571 0.726 rs669371 chr11:65674153 G/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.52 -6.38 -0.37 7.7e-10 Eosinophil percentage of white cells; CESC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg09699651 chr6:150184138 LRP11 0.4 5.14 0.3 5.29e-7 Lung cancer; CESC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg06420487 chr17:61919686 SMARCD2 0.46 5.53 0.32 7.65e-8 Height; CESC cis rs2180341 0.924 rs6930849 chr6:127630963 A/T cg27446573 chr6:127587934 RNF146 1.09 16.33 0.71 5.73e-42 Breast cancer; CESC cis rs6582630 0.599 rs1589392 chr12:38418535 G/C cg26384229 chr12:38710491 ALG10B -0.45 -6.09 -0.35 4.05e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg11366901 chr6:160182831 ACAT2 0.8 10.07 0.53 2.14e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs12200560 0.505 rs211178 chr6:97074094 T/A cg06623918 chr6:96969491 KIAA0776 0.52 6.65 0.38 1.71e-10 Coronary heart disease; CESC cis rs3105593 0.933 rs2414059 chr15:50873344 T/A cg08437265 chr15:50716283 USP8 0.42 5.47 0.32 1.05e-7 QT interval; CESC trans rs9325144 0.647 rs61931899 chr12:38892422 A/G cg10679878 chr6:156759499 NA -0.34 -6.09 -0.35 4.04e-9 Morning vs. evening chronotype; CESC cis rs1801251 1.000 rs7558609 chr2:233700379 C/T cg25237894 chr2:233734115 C2orf82 0.45 7.76 0.43 1.9e-13 Coronary artery disease; CESC trans rs17685 0.884 rs6978677 chr7:75636240 C/T cg19862616 chr7:65841803 NCRNA00174 0.68 8.86 0.48 1.2e-16 Coffee consumption;Coffee consumption (cups per day); CESC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.13 22.65 0.81 6.31e-64 Prudent dietary pattern; CESC trans rs4664304 0.620 rs2556086 chr2:160708446 G/T cg03768106 chr11:111957237 TIMM8B;SDHD 0.43 6.09 0.35 4e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg17372223 chr3:52568218 NT5DC2 0.45 7.53 0.42 7.97e-13 Bipolar disorder; CESC cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg19052272 chr2:3704530 ALLC -0.48 -5.85 -0.34 1.41e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs79976124 0.842 rs7760550 chr6:66628788 T/C cg07460842 chr6:66804631 NA 0.68 8.06 0.44 2.65e-14 Type 2 diabetes; CESC cis rs634534 0.622 rs501353 chr11:65739549 T/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.64 8.87 0.48 1.12e-16 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs4794106 0.792 rs847682 chr17:48208274 C/T cg13127421 chr17:48202128 SAMD14 -0.53 -7.66 -0.43 3.6e-13 Temporomandibular joint disorder; CESC cis rs4242434 0.672 rs2404654 chr8:22484949 T/C cg03733263 chr8:22462867 KIAA1967 0.74 11.08 0.56 1.11e-23 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg02038168 chr22:39784481 NA -0.63 -7.95 -0.44 5.4e-14 Intelligence (multi-trait analysis); CESC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg05368731 chr17:41323189 NBR1 0.78 10.6 0.55 3.92e-22 Menopause (age at onset); CESC cis rs11190604 1.000 rs2489035 chr10:102319395 C/T cg07080220 chr10:102295463 HIF1AN 0.62 5.9 0.34 1.1e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs28489187 0.667 rs233114 chr1:85786957 T/G cg16011679 chr1:85725395 C1orf52 0.48 5.65 0.33 4.1e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs72781680 0.898 rs72782106 chr2:24022009 A/G cg20701182 chr2:24300061 SF3B14 0.78 6.7 0.38 1.22e-10 Lymphocyte counts; CESC cis rs4604732 0.631 rs12038880 chr1:247624603 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.4 5.34 0.31 2.05e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4803468 1.000 rs284652 chr19:41928652 C/T cg08639244 chr19:41945921 ATP5SL -0.42 -5.11 -0.3 6.12e-7 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25094149 chr1:32253906 NA -0.43 -6.07 -0.35 4.43e-9 Gut microbiota (bacterial taxa); CESC cis rs9457247 0.582 rs9459855 chr6:167466150 G/T cg07741184 chr6:167504864 NA 0.37 6.49 0.37 4.2e-10 Crohn's disease; CESC trans rs561341 0.882 rs2428337 chr17:30299467 C/T cg27661571 chr11:113659931 NA -0.83 -7.69 -0.43 2.82e-13 Hip circumference adjusted for BMI; CESC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.47 -0.32 1.03e-7 Aortic root size; CESC cis rs2204008 0.577 rs11520050 chr12:38051839 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs950173 1.000 rs950173 chr2:172570419 G/A cg13550731 chr2:172543902 DYNC1I2 -0.85 -6.11 -0.35 3.55e-9 Hippocampal volume; CESC cis rs9916302 0.904 rs10221223 chr17:37489100 T/G cg00129232 chr17:37814104 STARD3 0.51 6.37 0.36 8.22e-10 Glomerular filtration rate (creatinine); CESC cis rs1670533 1.000 rs6827357 chr4:1059202 A/C cg27284194 chr4:1044797 NA 0.46 5.32 0.31 2.2e-7 Recombination rate (females); CESC cis rs8141529 0.711 rs5752797 chr22:29179998 C/T cg15103426 chr22:29168792 CCDC117 0.48 5.15 0.3 5.19e-7 Lymphocyte counts; CESC trans rs561341 0.941 rs72825746 chr17:30364610 G/A cg20587970 chr11:113659929 NA -1.51 -20.19 -0.78 1.54e-55 Hip circumference adjusted for BMI; CESC cis rs2290159 0.800 rs55762590 chr3:12689451 C/T cg23032965 chr3:12705835 RAF1 0.55 5.86 0.34 1.38e-8 Cholesterol, total; CESC cis rs9951602 1.000 rs7232284 chr18:76667529 A/G cg00806245 chr18:76673096 NA -0.55 -6.83 -0.39 5.88e-11 Obesity-related traits; CESC cis rs829883 0.932 rs249840 chr12:98871993 T/C cg25150519 chr12:98850993 NA 0.68 9.14 0.49 1.7e-17 Colorectal adenoma (advanced); CESC cis rs1801251 0.963 rs7562712 chr2:233606580 A/G cg25237894 chr2:233734115 C2orf82 0.45 7.84 0.43 1.1e-13 Coronary artery disease; CESC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg17376030 chr22:41985996 PMM1 0.67 7.47 0.42 1.14e-12 Vitiligo; CESC cis rs34779708 0.966 rs35814343 chr10:35427714 G/T cg04310649 chr10:35416472 CREM -0.5 -6.04 -0.35 5.31e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg07507251 chr3:52567010 NT5DC2 0.4 6.92 0.39 3.39e-11 Bipolar disorder; CESC cis rs4925325 0.876 rs6089560 chr20:60517325 T/G cg18761221 chr20:60518478 NA 0.58 8.51 0.46 1.34e-15 Obesity-related traits; CESC cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg07697082 chr8:82753677 SNX16 -0.39 -6.08 -0.35 4.26e-9 Diastolic blood pressure; CESC cis rs9768139 0.903 rs28503558 chr7:158119568 C/T cg24154853 chr7:158122151 PTPRN2 -0.37 -5.82 -0.34 1.66e-8 Calcium levels; CESC cis rs67311347 1.000 rs13073003 chr3:40504326 C/T cg09455208 chr3:40491958 NA -0.47 -8.03 -0.44 3.14e-14 Renal cell carcinoma; CESC cis rs2243480 0.708 rs781141 chr7:65438553 A/G cg13147721 chr7:65941812 NA -0.86 -8.55 -0.47 9.73e-16 Diabetic kidney disease; CESC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg09877947 chr5:131593287 PDLIM4 0.46 6.02 0.35 5.86e-9 Breast cancer; CESC cis rs6430585 0.528 rs16832417 chr2:136744678 C/T cg07169764 chr2:136633963 MCM6 1.28 17.38 0.73 1.11e-45 Corneal structure; CESC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg19622623 chr12:86230825 RASSF9 -0.47 -6.05 -0.35 4.94e-9 Major depressive disorder; CESC trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21582582 chr3:182698605 DCUN1D1 -0.44 -6.01 -0.35 6.2e-9 Intelligence (multi-trait analysis); CESC cis rs4722166 0.695 rs6946509 chr7:22809490 T/C cg05472934 chr7:22766657 IL6 0.61 8.18 0.45 1.22e-14 Lung cancer; CESC cis rs72781680 0.898 rs72781639 chr2:24204148 C/G cg20701182 chr2:24300061 SF3B14 0.63 5.58 0.32 6.04e-8 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25308054 chr19:10676770 KRI1 0.59 6.85 0.39 5.02e-11 Gut microbiome composition (summer); CESC cis rs2282802 0.651 rs13353827 chr5:139654537 T/C cg26211634 chr5:139558579 C5orf32 0.51 7.37 0.41 2.24e-12 Intelligence (multi-trait analysis); CESC cis rs4803468 0.967 rs3745290 chr19:41890003 C/T cg14132834 chr19:41945861 ATP5SL -0.55 -6.81 -0.39 6.37e-11 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26185531 chr11:75479825 DGAT2 -0.47 -6.51 -0.37 3.79e-10 Fibrinogen levels; CESC cis rs763121 0.853 rs138716 chr22:39146527 C/T cg21395723 chr22:39101663 GTPBP1 0.43 5.35 0.31 1.93e-7 Menopause (age at onset); CESC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg11663144 chr21:46675770 NA -0.63 -9.75 -0.51 2.19e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7246657 0.882 rs6508716 chr19:37819010 T/C cg24637308 chr11:6592297 DNHD1 0.53 6.24 0.36 1.74e-9 Coronary artery calcification; CESC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 11.48 0.58 4.99e-25 Platelet count; CESC cis rs1003719 0.715 rs13046581 chr21:38551985 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.13 -0.45 1.62e-14 Eye color traits; CESC cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg18305652 chr10:134549665 INPP5A 0.51 7.67 0.43 3.32e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg07092213 chr7:1199455 ZFAND2A -0.51 -5.37 -0.31 1.7e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs478304 0.903 rs12293022 chr11:65531698 C/T cg08755490 chr11:65554678 OVOL1 0.46 6.15 0.35 2.85e-9 Acne (severe); CESC cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg25019033 chr10:957182 NA -0.63 -7.03 -0.4 1.72e-11 Eosinophil percentage of granulocytes; CESC cis rs7165102 1.000 rs352479 chr15:65803428 C/A cg11441148 chr15:65824328 PTPLAD1 -0.32 -5.33 -0.31 2.07e-7 Mean corpuscular hemoglobin; CESC cis rs6964587 0.869 rs405 chr7:91546327 G/C cg01689657 chr7:91764605 CYP51A1 -0.28 -5.03 -0.3 9.02e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27247569 chr16:88097866 BANP -0.57 -6.14 -0.35 3.02e-9 Gut microbiome composition (summer); CESC cis rs17376456 0.778 rs10440717 chr5:93424852 C/A cg21475434 chr5:93447410 FAM172A 0.81 7.42 0.41 1.55e-12 Diabetic retinopathy; CESC cis rs2070488 0.560 rs1381798 chr3:38437471 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.61 -7.61 -0.42 4.89e-13 Electrocardiographic conduction measures; CESC cis rs561341 0.769 rs9899093 chr17:30191954 C/G cg00745463 chr17:30367425 LRRC37B -0.59 -5.53 -0.32 7.61e-8 Hip circumference adjusted for BMI; CESC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.49 -0.32 9.23e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9303401 0.703 rs9909925 chr17:57210069 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.6 -7.73 -0.43 2.19e-13 Cognitive test performance; CESC cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7208859 0.524 rs60114476 chr17:29097667 A/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9948 0.786 rs72809850 chr2:97449762 A/C cg01990225 chr2:97406019 LMAN2L -0.92 -7.51 -0.42 9.04e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs477692 0.583 rs12415589 chr10:131428336 C/G cg05714579 chr10:131428358 MGMT -0.75 -11.97 -0.59 1.08e-26 Response to temozolomide; CESC cis rs7071206 0.947 rs1877998 chr10:79411740 C/T cg23888215 chr10:79422304 NA -0.53 -5.71 -0.33 2.96e-8 Bone mineral density; CESC cis rs7208859 0.673 rs78799101 chr17:29215160 A/T cg19761014 chr17:28927070 LRRC37B2 0.71 5.61 0.33 5.2100000000000003e-08 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.58 8.19 0.45 1.15e-14 Intelligence (multi-trait analysis); CESC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs3820928 0.874 rs3769646 chr2:227896330 C/T cg05526886 chr2:227700861 RHBDD1 -0.44 -5.69 -0.33 3.28e-8 Pulmonary function; CESC cis rs7546094 0.967 rs351372 chr1:113059220 A/T cg22162597 chr1:113214053 CAPZA1 0.38 5.86 0.34 1.39e-8 Platelet distribution width; CESC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.59 8.42 0.46 2.37e-15 Bipolar disorder; CESC cis rs12618769 0.597 rs3754893 chr2:99063149 T/A cg10123293 chr2:99228465 UNC50 0.39 5.18 0.3 4.49e-7 Bipolar disorder; CESC cis rs4332037 0.901 rs7791899 chr7:1935988 T/C cg23422044 chr7:1970798 MAD1L1 -0.55 -5.65 -0.33 4.07e-8 Bipolar disorder; CESC cis rs701145 0.556 rs355787 chr3:153994502 T/C cg16511985 chr3:153974050 SGEF 0.43 5.88 0.34 1.22e-8 Coronary artery disease; CESC cis rs5753618 0.504 rs9609303 chr22:31896309 C/T cg13145458 chr22:31556086 RNF185 -0.53 -6.25 -0.36 1.63e-9 Colorectal cancer; CESC cis rs10979 0.964 rs35205240 chr6:143898676 T/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.12 -0.49 1.91e-17 Hypospadias; CESC cis rs17125944 0.505 rs80211268 chr14:53265483 C/G cg13660082 chr14:53194042 PSMC6 -0.66 -5.81 -0.34 1.78e-8 Alzheimer's disease (late onset); CESC cis rs13256369 0.802 rs11781257 chr8:8559663 A/T cg18904891 chr8:8559673 CLDN23 0.72 7.98 0.44 4.42e-14 Obesity-related traits; CESC cis rs11997175 0.545 rs4733458 chr8:33661542 G/T ch.8.33884649F chr8:33765107 NA 0.56 7.13 0.4 9.26e-12 Body mass index; CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T ch.2.195648145F chr2:195939902 NA 0.55 6.24 0.36 1.7e-9 Endometrial cancer; CESC cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg11764359 chr7:65958608 NA -0.64 -7.98 -0.44 4.42e-14 Aortic root size; CESC cis rs2425143 1.000 rs6060591 chr20:34351476 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -8.0 -0.44 3.85e-14 Blood protein levels; CESC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg11247378 chr22:39784982 NA -0.58 -7.88 -0.44 8.36e-14 Intelligence (multi-trait analysis); CESC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg05564831 chr3:52568323 NT5DC2 0.46 6.93 0.39 3.15e-11 Bipolar disorder; CESC cis rs1801251 1.000 rs6738386 chr2:233602028 T/C cg25237894 chr2:233734115 C2orf82 0.44 7.55 0.42 7.05e-13 Coronary artery disease; CESC cis rs12477438 0.798 rs4851179 chr2:99568774 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.4 -0.54 1.77e-21 Chronic sinus infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10330885 chr16:88729968 MGC23284;MVD 0.44 6.32 0.36 1.1e-9 Fibrinogen levels; CESC cis rs2635047 0.967 rs2668786 chr18:44708472 A/G cg24371990 chr18:44770781 NA 0.34 5.33 0.31 2.11e-7 Educational attainment; CESC cis rs72781680 0.898 rs72798064 chr2:23982832 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.54 0.32 7.13e-8 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24688926 chr19:6737877 GPR108 -0.63 -7.24 -0.41 4.86e-12 Gut microbiome composition (summer); CESC cis rs7216064 0.684 rs8182243 chr17:66018505 T/C cg12091567 chr17:66097778 LOC651250 0.86 11.3 0.57 1.95e-24 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.16 0.81 2.75e-62 Prudent dietary pattern; CESC cis rs9814567 1.000 rs35718987 chr3:134272783 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00338893 chr7:140714614 MRPS33 -0.5 -6.22 -0.36 1.96e-9 Gut microbiome composition (summer); CESC cis rs8070128 0.600 rs8071238 chr17:17900990 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.13 0.35 3.22e-9 Total body bone mineral density; CESC cis rs7216064 1.000 rs11870068 chr17:65944515 A/C cg07042672 chr17:66097459 LOC651250 -0.53 -5.67 -0.33 3.66e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9926296 0.533 rs12102297 chr16:89812762 C/A cg03388025 chr16:89894329 SPIRE2 0.39 7.42 0.41 1.63e-12 Vitiligo; CESC cis rs9837602 0.592 rs1711557 chr3:99425669 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -5.36 -0.31 1.77e-7 Breast cancer; CESC cis rs7959452 0.535 rs4761228 chr12:69682327 G/A cg20891283 chr12:69753455 YEATS4 0.75 10.8 0.55 8.98e-23 Blood protein levels; CESC cis rs7618501 0.633 rs2008877 chr3:50162291 T/G cg24308560 chr3:49941425 MST1R 0.57 8.07 0.44 2.42e-14 Intelligence (multi-trait analysis); CESC cis rs7914558 0.966 rs10748836 chr10:104693917 G/A cg08650961 chr10:104748594 CNNM2 0.32 5.16 0.3 4.94e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6690583 0.562 rs6688354 chr1:85520854 A/G cg11262906 chr1:85462892 MCOLN2 0.54 5.14 0.3 5.46e-7 Serum sulfate level; CESC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg24060327 chr5:131705240 SLC22A5 -0.47 -6.09 -0.35 4.03e-9 Acylcarnitine levels; CESC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.87 -0.34 1.27e-8 Total body bone mineral density; CESC cis rs2795502 0.882 rs2744087 chr10:43340270 A/C cg20628663 chr10:43360327 NA -0.63 -7.47 -0.42 1.16e-12 Blood protein levels; CESC cis rs7872515 0.887 rs7856177 chr9:94839342 A/G cg01248375 chr9:94877805 SPTLC1 0.53 5.94 0.34 8.91e-9 Bipolar disorder and schizophrenia; CESC cis rs8072100 1.000 rs7210738 chr17:45757598 G/A cg08085267 chr17:45401833 C17orf57 0.41 5.44 0.32 1.21e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7592578 0.771 rs1128723 chr2:191366707 A/G cg27211696 chr2:191398769 TMEM194B -0.61 -5.49 -0.32 9.37e-8 Diastolic blood pressure; CESC cis rs2228479 0.850 rs62054610 chr16:89816920 G/A cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs9303401 0.646 rs8067682 chr17:57219391 A/G cg12560992 chr17:57184187 TRIM37 0.42 5.07 0.3 7.32e-7 Cognitive test performance; CESC cis rs6460942 0.630 rs17671056 chr7:12390961 C/G cg06484146 chr7:12443880 VWDE -0.65 -7.09 -0.4 1.23e-11 Coronary artery disease; CESC cis rs2991971 0.716 rs7532573 chr1:45915892 A/T cg05343316 chr1:45956843 TESK2 0.59 8.4 0.46 2.75e-15 High light scatter reticulocyte count; CESC cis rs11677370 0.561 rs10191326 chr2:3827524 G/C cg17052675 chr2:3827356 NA -0.43 -5.45 -0.32 1.14e-7 Type 2 diabetes; CESC trans rs4424809 0.614 rs79094539 chr13:85572909 A/T cg05918002 chr17:5019452 ZNF232 -0.63 -6.08 -0.35 4.29e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC trans rs57221529 0.766 rs12518859 chr5:587432 C/T cg25482853 chr8:67687455 SGK3 1.01 9.99 0.52 3.67e-20 Lung disease severity in cystic fibrosis; CESC cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg01579765 chr21:45077557 HSF2BP -0.56 -9.42 -0.5 2.33e-18 Mean corpuscular volume; CESC cis rs79976124 0.837 rs10944858 chr6:66646039 G/A cg07460842 chr6:66804631 NA 0.71 8.33 0.46 4.36e-15 Type 2 diabetes; CESC cis rs1538970 0.816 rs9727262 chr1:45998579 T/G cg03146154 chr1:46216737 IPP 0.49 5.59 0.32 5.71e-8 Platelet count; CESC cis rs754466 1.000 rs67059283 chr10:79683235 C/T cg17075019 chr10:79541650 NA -0.76 -9.65 -0.51 4.4e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12477438 0.520 rs4588238 chr2:99749350 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.46 0.69 7.45e-39 Chronic sinus infection; CESC cis rs66887589 0.934 rs4834792 chr4:120555696 T/A cg09307838 chr4:120376055 NA -0.44 -5.85 -0.34 1.42e-8 Diastolic blood pressure; CESC cis rs2760061 0.717 rs708117 chr1:228199902 G/A cg02753203 chr1:228287806 NA 0.51 7.61 0.42 4.89e-13 Diastolic blood pressure; CESC cis rs4975616 0.836 rs460073 chr5:1336459 T/C cg07493874 chr5:1342172 CLPTM1L -0.41 -7.85 -0.43 1.02e-13 Lung cancer; CESC cis rs11098499 0.954 rs13133522 chr4:120324424 A/T cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs2243480 0.614 rs34032527 chr7:65565141 C/G cg13147721 chr7:65941812 NA -0.98 -9.11 -0.49 2.06e-17 Diabetic kidney disease; CESC cis rs9467711 0.606 rs12174631 chr6:26373150 C/T cg12826209 chr6:26865740 GUSBL1 0.61 5.28 0.31 2.72e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9457247 0.534 rs12055488 chr6:167379570 A/G cg23791538 chr6:167370224 RNASET2 0.65 9.17 0.49 1.33e-17 Crohn's disease; CESC cis rs2832191 0.550 rs66484040 chr21:30511691 G/A cg08807101 chr21:30365312 RNF160 -0.54 -6.29 -0.36 1.33e-9 Dental caries; CESC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg06634786 chr22:41940651 POLR3H 0.74 7.63 0.42 4.36e-13 Vitiligo; CESC cis rs11792861 0.926 rs75128146 chr9:111833791 G/T cg05043794 chr9:111880884 C9orf5 -0.4 -6.53 -0.37 3.36e-10 Menarche (age at onset); CESC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg27478167 chr7:817139 HEATR2 -0.48 -5.16 -0.3 4.93e-7 Cerebrospinal P-tau181p levels; CESC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg17971929 chr21:40555470 PSMG1 0.87 12.55 0.61 1.18e-28 Cognitive function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13675319 chr9:31254329 NA 0.41 6.1 0.35 3.84e-9 Fibrinogen levels; CESC cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg05340658 chr4:99064831 C4orf37 0.82 12.75 0.62 2.34e-29 Colonoscopy-negative controls vs population controls; CESC cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg12193833 chr17:30244370 NA -0.72 -6.35 -0.36 9.13e-10 Hip circumference adjusted for BMI; CESC cis rs1008375 0.932 rs11934968 chr4:17667766 A/G cg16339924 chr4:17578868 LAP3 0.58 6.75 0.38 9.2e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs642803 0.591 rs620088 chr11:65508986 G/A cg02870584 chr11:65547924 DKFZp761E198 0.53 6.69 0.38 1.36e-10 Urate levels; CESC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg21033440 chr11:65409861 SIPA1 -0.58 -7.09 -0.4 1.25e-11 Blood pressure (age interaction); CESC cis rs116095464 0.558 rs10057626 chr5:239720 T/G cg20965017 chr5:231967 SDHA -0.47 -5.3 -0.31 2.49e-7 Breast cancer; CESC trans rs208520 0.754 rs1100989 chr6:66880532 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.51 -0.61 1.58e-28 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13795627 chr1:157015873 ARHGEF11 0.62 7.23 0.41 5.09e-12 Gut microbiome composition (summer); CESC cis rs9811920 0.638 rs704581 chr3:99556160 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -5.72 -0.33 2.8e-8 Axial length; CESC cis rs7246657 0.943 rs10405064 chr19:37861861 C/T cg23950597 chr19:37808831 NA -0.61 -6.18 -0.35 2.39e-9 Coronary artery calcification; CESC cis rs2573652 0.755 rs1469830 chr15:100517403 G/T cg00587665 chr15:100533223 ADAMTS17 0.34 5.27 0.31 2.9e-7 Height; CESC cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2832191 0.791 rs2832199 chr21:30498501 G/A cg24692254 chr21:30365293 RNF160 -0.8 -12.29 -0.6 9.16e-28 Dental caries; CESC cis rs909002 0.800 rs1061770 chr1:32096265 A/G cg13919466 chr1:32135498 COL16A1 -0.45 -8.04 -0.44 2.96e-14 Intelligence (multi-trait analysis); CESC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg11301795 chr4:187892539 NA -0.75 -12.37 -0.61 4.63e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg24308560 chr3:49941425 MST1R 0.57 8.16 0.45 1.32e-14 Body mass index; CESC cis rs7546094 0.935 rs7554345 chr1:113122956 T/G cg22162597 chr1:113214053 CAPZA1 0.37 5.67 0.33 3.64e-8 Platelet distribution width; CESC cis rs11630290 0.592 rs12324556 chr15:64160951 G/A cg12036633 chr15:63758958 NA 0.45 5.35 0.31 1.92e-7 Iris characteristics; CESC cis rs7772486 0.846 rs2748499 chr6:146315002 T/C cg05347473 chr6:146136440 FBXO30 0.52 6.88 0.39 4.32e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4566357 0.615 rs12328876 chr2:227918899 G/T cg05526886 chr2:227700861 RHBDD1 -0.55 -6.97 -0.39 2.59e-11 Coronary artery disease; CESC cis rs1153858 0.832 rs1145078 chr15:45682277 C/T cg21132104 chr15:45694354 SPATA5L1 0.77 10.24 0.53 5.77e-21 Homoarginine levels; CESC cis rs950027 0.620 rs2467862 chr15:45643843 T/G cg21132104 chr15:45694354 SPATA5L1 0.66 8.52 0.46 1.22e-15 Response to fenofibrate (adiponectin levels); CESC cis rs2180341 0.960 rs3756996 chr6:127664258 G/C cg24812749 chr6:127587940 RNF146 1.07 15.08 0.68 1.65e-37 Breast cancer; CESC trans rs7246760 1.000 rs58137206 chr19:9856624 G/A cg02900749 chr2:68251473 NA -0.77 -7.15 -0.4 8.22e-12 Pursuit maintenance gain; CESC cis rs2836633 1.000 rs2836633 chr21:40067445 C/T cg12884169 chr21:40033163 ERG -0.33 -5.36 -0.31 1.84e-7 Coronary artery disease; CESC cis rs9911578 1.000 rs304270 chr17:56802141 A/G cg12560992 chr17:57184187 TRIM37 -0.91 -15.39 -0.69 1.32e-38 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.9 0.34 1.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -6.76 -0.38 8.8e-11 Personality dimensions; CESC cis rs7267979 1.000 rs453329 chr20:25440593 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.85 16.7 0.72 2.9e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs2730245 0.527 rs842693 chr7:158660491 C/T cg24397884 chr7:158709396 WDR60 0.8 8.01 0.44 3.67e-14 Height; CESC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg04315214 chr1:2043799 PRKCZ 0.61 10.74 0.55 1.37e-22 Height; CESC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.35 0.31 1.89e-7 Menopause (age at onset); CESC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg26335602 chr6:28129616 ZNF389 0.41 5.43 0.32 1.25e-7 Parkinson's disease; CESC cis rs2644899 0.594 rs11668644 chr19:41316746 G/C cg24958765 chr19:41283667 RAB4B -0.54 -5.89 -0.34 1.14e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs7085104 0.727 rs12773892 chr10:104631177 G/T cg04362960 chr10:104952993 NT5C2 0.64 6.08 0.35 4.26e-9 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs992157 0.560 rs7605980 chr2:219100869 C/G cg00012203 chr2:219082015 ARPC2 0.72 9.43 0.5 2.15e-18 Colorectal cancer; CESC cis rs17401966 0.809 rs12406943 chr1:10308545 T/C cg15208524 chr1:10270712 KIF1B 0.38 5.04 0.3 8.75e-7 Hepatocellular carcinoma; CESC cis rs4423214 1.000 rs4944958 chr11:71168073 A/G cg05163923 chr11:71159392 DHCR7 0.77 10.4 0.54 1.76e-21 Vitamin D levels; CESC cis rs727505 1.000 rs66665074 chr7:124550526 C/T cg23710748 chr7:124431027 NA -0.47 -7.45 -0.42 1.35e-12 Lewy body disease; CESC cis rs9486715 0.838 rs6928442 chr6:96870118 A/G cg06623918 chr6:96969491 KIAA0776 0.91 14.05 0.65 6.83e-34 Headache; CESC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg14159672 chr1:205819179 PM20D1 0.51 7.36 0.41 2.36e-12 Menarche (age at onset); CESC cis rs2625529 0.824 rs7170461 chr15:72218599 C/A cg16672083 chr15:72433130 SENP8 -0.39 -5.06 -0.3 7.68e-7 Red blood cell count; CESC cis rs1545257 0.514 rs7581577 chr2:24638107 C/T cg06627628 chr2:24431161 ITSN2 -0.48 -5.88 -0.34 1.21e-8 Sjögren's syndrome; CESC cis rs854765 0.647 rs2974999 chr17:17997547 T/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.63 0.47 5.93e-16 Total body bone mineral density; CESC cis rs763121 0.853 rs1043441 chr22:39130964 C/T cg21395723 chr22:39101663 GTPBP1 0.47 6.12 0.35 3.37e-9 Menopause (age at onset); CESC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs2408955 0.500 rs12816820 chr12:48558325 A/G cg24011408 chr12:48396354 COL2A1 0.49 7.41 0.41 1.69e-12 Glycated hemoglobin levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16263701 chr12:48213605 HDAC7 0.53 7.28 0.41 3.73e-12 Gut microbiota (bacterial taxa); CESC cis rs34779708 0.702 rs35969476 chr10:35544318 G/A cg03585969 chr10:35415529 CREM 0.56 6.54 0.37 3.22e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs2302729 0.929 rs7136355 chr12:2783476 T/C cg19945202 chr12:2788847 CACNA1C -0.45 -5.22 -0.31 3.53e-7 Sleep quality; CESC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg05368731 chr17:41323189 NBR1 0.78 10.41 0.54 1.66e-21 Menopause (age at onset); CESC cis rs9583531 0.600 rs7984468 chr13:111362093 C/A cg15841412 chr13:111365552 ING1 0.52 6.74 0.38 1.01e-10 Coronary artery disease; CESC cis rs9443645 0.810 rs9448610 chr6:79739622 G/A cg05283184 chr6:79620031 NA -0.39 -6.05 -0.35 4.81e-9 Intelligence (multi-trait analysis); CESC cis rs12142240 0.731 rs6681857 chr1:46850124 T/C cg10495392 chr1:46806563 NSUN4 0.55 5.98 0.34 7.21e-9 Menopause (age at onset); CESC trans rs11039798 0.588 rs11039855 chr11:48610091 A/G cg15704280 chr7:45808275 SEPT13 0.61 6.29 0.36 1.32e-9 Axial length; CESC cis rs6732160 0.691 rs13402225 chr2:73416906 T/G cg01422370 chr2:73384389 NA 0.42 7.15 0.4 8.6e-12 Intelligence (multi-trait analysis); CESC cis rs898097 0.607 rs2199111 chr17:80823203 A/G cg15664640 chr17:80829946 TBCD -0.4 -5.66 -0.33 4.01e-8 Breast cancer; CESC cis rs61931739 0.500 rs56404399 chr12:34543101 A/G cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs1801251 1.000 rs283476 chr2:233650168 A/G cg25237894 chr2:233734115 C2orf82 0.44 7.63 0.42 4.22e-13 Coronary artery disease; CESC cis rs763121 0.853 rs5750622 chr22:38956464 C/G cg06544989 chr22:39130855 UNC84B 0.49 8.18 0.45 1.16e-14 Menopause (age at onset); CESC cis rs12135062 1.000 rs12135062 chr1:3103312 A/C cg25382214 chr1:3105252 PRDM16 0.38 5.04 0.3 8.58e-7 Migraine; CESC cis rs9303401 0.704 rs740605 chr17:56604811 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.56 7.53 0.42 8.06e-13 Cognitive test performance; CESC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg00129232 chr17:37814104 STARD3 0.59 7.88 0.44 8.71e-14 Glomerular filtration rate (creatinine); CESC cis rs6088590 0.930 rs6087618 chr20:33288407 C/T cg24642439 chr20:33292090 TP53INP2 0.85 12.0 0.59 8.93e-27 Coronary artery disease; CESC cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg20476274 chr7:133979776 SLC35B4 0.65 9.4 0.5 2.76e-18 Mean platelet volume; CESC cis rs4654899 0.758 rs6689852 chr1:21341051 T/C cg05370193 chr1:21551575 ECE1 0.37 5.65 0.33 4.12e-8 Superior frontal gyrus grey matter volume; CESC cis rs9300255 0.596 rs10734900 chr12:123743445 G/A cg05973401 chr12:123451056 ABCB9 0.44 5.46 0.32 1.12e-7 Neutrophil percentage of white cells; CESC cis rs6991838 0.584 rs57042777 chr8:66489090 T/A cg13398993 chr8:66546079 ARMC1 -0.46 -5.54 -0.32 7.22e-8 Intelligence (multi-trait analysis); CESC cis rs12477438 0.798 rs1580068 chr2:99649969 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs7904368 0.754 rs7076779 chr10:16852667 C/T cg14835575 chr10:16859367 RSU1 0.47 5.04 0.3 8.69e-7 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs208520 0.690 rs851468 chr6:66825875 G/A cg07460842 chr6:66804631 NA -1.01 -13.46 -0.64 8.19e-32 Exhaled nitric oxide output; CESC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs4253772 0.513 rs9306512 chr22:46716603 T/C cg09491104 chr22:46646882 C22orf40 -0.59 -8.98 -0.48 5.35e-17 LDL cholesterol;Cholesterol, total; CESC cis rs748404 0.650 rs518234 chr15:43573421 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.59 7.76 0.43 1.84e-13 Lung cancer; CESC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs35146811 0.660 rs6465760 chr7:99591418 A/G cg22531904 chr7:99595276 NA 0.38 5.1 0.3 6.46e-7 Coronary artery disease; CESC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg17376030 chr22:41985996 PMM1 0.66 7.22 0.41 5.44e-12 Vitiligo; CESC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg17971929 chr21:40555470 PSMG1 1.03 15.89 0.7 2.13e-40 Cognitive function; CESC cis rs9549328 0.885 rs3011546 chr13:113637009 T/A cg18110590 chr13:113636679 MCF2L 0.53 6.79 0.38 7.35e-11 Systolic blood pressure; CESC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg03934478 chr11:495069 RNH1 0.57 5.79 0.34 1.95e-8 Body mass index; CESC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.38 0.54 2.06e-21 Prudent dietary pattern; CESC cis rs4722166 0.597 rs1554606 chr7:22768707 T/G cg05472934 chr7:22766657 IL6 0.66 8.97 0.48 5.53e-17 Lung cancer; CESC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg25566285 chr7:158114605 PTPRN2 0.46 7.72 0.43 2.46e-13 Calcium levels; CESC cis rs35110281 0.667 rs914197 chr21:45117439 A/G cg04455712 chr21:45112962 RRP1B 0.47 7.13 0.4 9.39e-12 Mean corpuscular volume; CESC cis rs11190604 1.000 rs10883502 chr10:102238343 T/G cg07080220 chr10:102295463 HIF1AN 0.56 5.59 0.32 5.61e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20646995 chr7:102105124 LRWD1;ALKBH4 -0.48 -6.35 -0.36 9.09e-10 Height; CESC cis rs1348850 0.914 rs12693120 chr2:178283288 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.8 11.46 0.58 5.62e-25 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4474465 0.850 rs4945287 chr11:78226521 C/T cg27205649 chr11:78285834 NARS2 0.43 5.23 0.31 3.44e-7 Alzheimer's disease (survival time); CESC cis rs7246657 0.943 rs4802136 chr19:37849811 T/A cg23950597 chr19:37808831 NA -0.57 -6.25 -0.36 1.67e-9 Coronary artery calcification; CESC cis rs9399135 0.967 rs4388304 chr6:135309597 T/A cg22676075 chr6:135203613 NA 0.52 7.21 0.4 5.95e-12 Red blood cell count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00304072 chr15:49338551 SECISBP2L -0.48 -6.24 -0.36 1.72e-9 Ulcerative colitis; CESC trans rs637571 0.544 rs55704213 chr11:65730002 C/A cg17712092 chr4:129076599 LARP1B 0.75 10.36 0.54 2.43e-21 Eosinophil percentage of white cells; CESC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg03665457 chr10:38645376 HSD17B7P2 -0.43 -5.31 -0.31 2.36e-7 Breast cancer; CESC cis rs7851660 0.967 rs7043885 chr9:100596439 C/T cg13688889 chr9:100608707 NA -0.68 -10.65 -0.55 2.84e-22 Strep throat; CESC cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg02375832 chr11:62437615 C11orf48 -0.39 -5.46 -0.32 1.09e-7 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs4253772 0.591 rs9615348 chr22:46729338 C/G cg00784671 chr22:46762841 CELSR1 -0.62 -6.0 -0.35 6.33e-9 LDL cholesterol;Cholesterol, total; CESC cis rs9309473 0.687 rs6747145 chr2:73609177 C/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.63 -0.38 1.92e-10 Metabolite levels; CESC cis rs7084402 0.935 rs1427195 chr10:60278967 T/C cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC cis rs9612 1.000 rs346527 chr19:44259361 A/G cg08581076 chr19:44259116 C19orf61 0.52 6.14 0.35 2.96e-9 Exhaled nitric oxide output; CESC cis rs11630290 0.806 rs72752906 chr15:64093465 G/T cg12036633 chr15:63758958 NA -0.56 -5.33 -0.31 2.06e-7 Iris characteristics; CESC cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg21881798 chr11:8931708 C11orf17;ST5 0.5 8.04 0.44 2.92e-14 Hemoglobin concentration; CESC cis rs2073300 0.609 rs6137951 chr20:23429459 T/C cg12062639 chr20:23401060 NAPB 0.93 6.51 0.37 3.78e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9611565 0.605 rs202638 chr22:41855458 A/G cg17376030 chr22:41985996 PMM1 -0.56 -6.45 -0.37 5.19e-10 Vitiligo; CESC trans rs11098499 0.954 rs17006190 chr4:120418838 C/G cg25214090 chr10:38739885 LOC399744 0.71 10.02 0.52 3.04e-20 Corneal astigmatism; CESC cis rs7927592 0.956 rs7124078 chr11:68298633 G/T cg16797656 chr11:68205561 LRP5 0.39 5.46 0.32 1.09e-7 Total body bone mineral density; CESC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg05064044 chr6:292385 DUSP22 -0.68 -8.75 -0.47 2.48e-16 Menopause (age at onset); CESC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg04553112 chr3:125709451 NA -0.56 -5.99 -0.35 6.78e-9 Blood pressure (smoking interaction); CESC cis rs2979489 0.891 rs3824107 chr8:30353412 A/G cg26383811 chr8:30366931 RBPMS 0.72 8.86 0.48 1.16e-16 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs7481584 0.624 rs438384 chr11:3045651 A/G cg08508325 chr11:3079039 CARS 0.31 5.1 0.3 6.52e-7 Calcium levels; CESC trans rs1437396 0.586 rs2867175 chr2:55622549 T/A cg07921503 chr7:2445843 CHST12 -0.24 -6.01 -0.35 6.16e-9 Alcohol dependence; CESC cis rs17401966 0.931 rs61778401 chr1:10426474 G/A cg15208524 chr1:10270712 KIF1B 0.4 5.12 0.3 6e-7 Hepatocellular carcinoma; CESC trans rs12478296 0.685 rs12473450 chr2:242991746 C/T cg18288967 chr1:45987694 PRDX1 0.61 6.98 0.39 2.38e-11 Obesity-related traits; CESC cis rs9837602 0.810 rs35885423 chr3:99813218 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 6.83 0.39 5.64e-11 Breast cancer; CESC cis rs7551222 0.752 rs12741351 chr1:204528256 G/A cg20240347 chr1:204465584 NA -0.28 -5.62 -0.33 4.73e-8 Schizophrenia; CESC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg04772025 chr11:68637568 NA 0.52 6.23 0.36 1.87e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8062405 1.000 rs8062405 chr16:28837906 C/T cg08761264 chr16:28874980 SH2B1 0.47 5.93 0.34 9.27e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs72781680 0.566 rs6713865 chr2:23899807 A/G cg08917208 chr2:24149416 ATAD2B 0.76 7.38 0.41 2.03e-12 Lymphocyte counts; CESC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg02018176 chr4:1364513 KIAA1530 0.41 5.82 0.34 1.72e-8 Longevity; CESC cis rs644799 0.601 rs7902 chr11:95565288 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.49 6.91 0.39 3.56e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs921968 0.643 rs539451 chr2:219426972 T/C cg02176678 chr2:219576539 TTLL4 0.39 6.86 0.39 4.81e-11 Mean corpuscular hemoglobin concentration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18171715 chr4:852160 GAK 0.49 6.28 0.36 1.37e-9 Fibrinogen levels; CESC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg22903657 chr4:1355424 KIAA1530 -0.4 -5.67 -0.33 3.82e-8 Obesity-related traits; CESC cis rs8092503 0.536 rs12956375 chr18:52443203 G/C cg12377874 chr18:52495404 RAB27B 0.34 5.14 0.3 5.36e-7 Childhood body mass index; CESC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.5 0.37 3.95e-10 Bipolar disorder; CESC cis rs9649213 0.614 rs12539761 chr7:98013839 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.43 -5.79 -0.34 1.95e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg00684032 chr4:1343700 KIAA1530 0.49 6.98 0.39 2.31e-11 Obesity-related traits; CESC cis rs9291683 0.632 rs13137074 chr4:10042842 C/T cg00071950 chr4:10020882 SLC2A9 0.83 14.41 0.66 3.63e-35 Bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08698015 chr17:72744834 SLC9A3R1 -0.52 -6.96 -0.39 2.6e-11 Fibrinogen levels; CESC cis rs12983728 1.000 rs12983728 chr19:58671267 G/A cg08687515 chr19:58661962 ZNF329 0.52 5.07 0.3 7.41e-7 Cholesterol, total; CESC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg08736216 chr1:53307985 ZYG11A 0.41 6.99 0.39 2.22e-11 Monocyte count; CESC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg12756686 chr19:29218302 NA 0.58 7.52 0.42 8.38e-13 Methadone dose in opioid dependence; CESC cis rs9768139 0.733 rs13309363 chr7:158122179 C/A cg24154853 chr7:158122151 PTPRN2 0.41 6.36 0.36 8.66e-10 Calcium levels; CESC cis rs9457247 0.967 rs2769355 chr6:167380493 G/A cg23791538 chr6:167370224 RNASET2 0.6 8.56 0.47 9.4e-16 Crohn's disease; CESC cis rs832540 0.519 rs6450411 chr5:56265771 A/G cg12311346 chr5:56204834 C5orf35 -0.44 -5.61 -0.33 5.07e-8 Coronary artery disease; CESC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg07153921 chr17:41440717 NA -0.4 -5.36 -0.31 1.79e-7 Menopause (age at onset); CESC trans rs208520 0.526 rs9294682 chr6:66795159 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.09 -23.75 -0.82 1.36e-67 Exhaled nitric oxide output; CESC cis rs7553864 0.614 rs4559475 chr1:87614236 T/C cg17420885 chr1:87600446 LOC339524 -0.46 -6.31 -0.36 1.18e-9 Smoking behavior; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01800426 chr8:17659068 MTUS1 0.53 6.31 0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs1348850 0.914 rs3813259 chr2:178257214 G/A cg22681709 chr2:178499509 PDE11A -0.43 -6.18 -0.36 2.34e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9309473 0.904 rs79145598 chr2:73821382 T/A cg20560298 chr2:73613845 ALMS1 -0.54 -6.85 -0.39 5.25e-11 Metabolite levels; CESC cis rs7659604 0.540 rs67150579 chr4:122704331 T/A cg19748678 chr4:122722346 EXOSC9 -0.42 -5.28 -0.31 2.64e-7 Type 2 diabetes; CESC trans rs9329221 0.683 rs658385 chr8:9892177 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.06 -0.4 1.45e-11 Neuroticism; CESC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg07308232 chr7:1071921 C7orf50 -0.6 -8.54 -0.46 1.04e-15 Longevity;Endometriosis; CESC cis rs4849845 0.637 rs11688038 chr2:121026582 A/G cg24070213 chr2:121070622 NA 0.44 6.52 0.37 3.44e-10 Mean platelet volume; CESC trans rs7615952 0.576 rs1127717 chr3:125826059 T/C cg07211511 chr3:129823064 LOC729375 -0.54 -6.07 -0.35 4.31e-9 Blood pressure (smoking interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10156188 chr7:102006302 NA -0.48 -6.0 -0.35 6.63e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC cis rs9611565 0.649 rs126092 chr22:42178441 A/G cg06634786 chr22:41940651 POLR3H 0.46 5.04 0.3 8.66e-7 Vitiligo; CESC cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg16262614 chr3:133464971 TF 0.43 8.64 0.47 5.58e-16 Iron status biomarkers (transferrin levels); CESC cis rs1559088 0.901 rs12610053 chr19:33582606 A/G cg17764715 chr19:33622953 WDR88 0.5 6.46 0.37 4.9e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00429477 chr12:6798907 ZNF384 0.6 6.31 0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs1062177 1.000 rs2915869 chr5:151171509 C/T cg12924095 chr5:151150029 G3BP1 0.49 6.44 0.37 5.67e-10 Preschool internalizing problems; CESC cis rs3820068 0.581 rs59991988 chr1:15950552 T/A cg13390004 chr1:15929781 NA 0.37 5.86 0.34 1.34e-8 Systolic blood pressure; CESC cis rs61996546 0.622 rs11629779 chr15:26845126 T/A cg15066197 chr15:26874202 GABRB3 -0.34 -5.09 -0.3 6.78e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.44 5.88 0.34 1.2e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08984405 chr17:685103 RNMTL1;GLOD4 0.48 6.56 0.37 2.84e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.74 0.64 8.59e-33 Prudent dietary pattern; CESC cis rs3859192 0.577 rs2227333 chr17:38174167 C/G cg17467752 chr17:38218738 THRA -0.47 -6.16 -0.35 2.69e-9 White blood cell count; CESC trans rs9467711 0.606 rs34104395 chr6:26478252 C/T cg01620082 chr3:125678407 NA -0.78 -6.1 -0.35 3.8e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7116495 1.000 rs4944258 chr11:71743393 T/A cg26138937 chr11:71823887 C11orf51 -0.82 -6.68 -0.38 1.39e-10 Severe influenza A (H1N1) infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12153709 chr19:56196971 EPN1 0.5 6.37 0.36 8.13e-10 Fibrinogen levels; CESC cis rs4727027 0.870 rs11524138 chr7:148799125 G/A cg23158103 chr7:148848205 ZNF398 -0.42 -6.93 -0.39 3.25e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10224311 chr22:35817371 MCM5 -0.54 -6.75 -0.38 9.42e-11 Gut microbiome composition (summer); CESC cis rs2404602 0.692 rs56193230 chr15:76934472 C/T cg26408565 chr15:76604113 ETFA -0.38 -5.44 -0.32 1.21e-7 Blood metabolite levels; CESC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 11.16 0.57 5.88e-24 Platelet count; CESC cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg23978390 chr7:1156363 C7orf50 0.42 5.21 0.31 3.74e-7 Bronchopulmonary dysplasia; CESC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg06873352 chr17:61820015 STRADA 0.73 13.07 0.63 1.78e-30 Prudent dietary pattern; CESC cis rs6669072 0.647 rs698274 chr1:91244177 A/G cg08895590 chr1:91227319 NA -0.32 -5.56 -0.32 6.53e-8 Cognitive function; CESC cis rs3806843 1.000 rs3733710 chr5:140167463 C/T cg26395211 chr5:140044315 WDR55 -0.42 -5.43 -0.32 1.28e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2832191 0.671 rs73346699 chr21:30515529 C/T cg24692254 chr21:30365293 RNF160 -0.63 -7.84 -0.43 1.13e-13 Dental caries; CESC cis rs9346455 0.614 rs58732838 chr6:72000496 C/T cg27238071 chr6:71998145 OGFRL1 0.63 6.1 0.35 3.77e-9 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs926392 0.932 rs4812360 chr20:37689259 A/G cg16355469 chr20:37678765 NA 0.4 5.08 0.3 7.06e-7 Dialysis-related mortality; CESC cis rs36051895 0.672 rs12353218 chr9:5162828 T/C cg02405213 chr9:5042618 JAK2 -0.54 -6.84 -0.39 5.41e-11 Pediatric autoimmune diseases; CESC cis rs854765 0.547 rs8075189 chr17:17901946 C/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.23 0.41 5.11e-12 Total body bone mineral density; CESC cis rs735396 0.770 rs1169314 chr12:121443116 A/G cg15155738 chr12:121454335 C12orf43 0.44 5.11 0.3 6.1e-7 N-glycan levels; CESC cis rs9443645 0.810 rs9448607 chr6:79715620 G/A cg05283184 chr6:79620031 NA -0.39 -6.17 -0.35 2.58e-9 Intelligence (multi-trait analysis); CESC cis rs911555 0.755 rs12432803 chr14:103930032 C/T cg12935359 chr14:103987150 CKB 0.65 9.46 0.5 1.73e-18 Intelligence (multi-trait analysis); CESC cis rs4595586 0.545 rs11609541 chr12:39378331 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs80130819 0.793 rs2634674 chr12:48744897 T/C cg05342945 chr12:48394962 COL2A1 -0.55 -5.83 -0.34 1.57e-8 Prostate cancer; CESC cis rs10463316 0.894 rs12652733 chr5:150753999 G/A cg03212797 chr5:150827313 SLC36A1 -0.42 -5.41 -0.32 1.41e-7 Metabolite levels (Pyroglutamine); CESC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg20999797 chr1:1681921 NA 0.28 5.38 0.31 1.63e-7 Body mass index; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg17735320 chr10:135192001 PAOX 0.47 6.04 0.35 5.17e-9 Thyroid stimulating hormone; CESC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg11764359 chr7:65958608 NA -0.78 -10.88 -0.56 4.83e-23 Aortic root size; CESC cis rs7191700 0.644 rs918738 chr16:11439679 C/G cg00044050 chr16:11439710 C16orf75 -0.49 -5.86 -0.34 1.36e-8 Multiple sclerosis; CESC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg17376030 chr22:41985996 PMM1 0.68 7.35 0.41 2.5e-12 Vitiligo; CESC cis rs3820068 0.580 rs36100011 chr1:16046920 C/T cg17385448 chr1:15911702 AGMAT 0.37 5.75 0.33 2.45e-8 Systolic blood pressure; CESC cis rs11031096 0.678 rs12223062 chr11:4180178 G/T cg18678763 chr11:4115507 RRM1 -0.43 -5.95 -0.34 8.24e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs7819412 0.703 rs2409713 chr8:11009797 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -6.42 -0.37 6.21e-10 Triglycerides; CESC cis rs60871478 1.000 rs4374882 chr7:821798 C/T cg05535760 chr7:792225 HEATR2 0.83 10.11 0.53 1.53e-20 Cerebrospinal P-tau181p levels; CESC cis rs2072499 0.898 rs2736609 chr1:156202640 C/T cg25208724 chr1:156163844 SLC25A44 0.84 13.27 0.63 3.75e-31 Testicular germ cell tumor; CESC cis rs478304 0.934 rs1193692 chr11:65504069 A/C cg08755490 chr11:65554678 OVOL1 0.46 6.14 0.35 3.09e-9 Acne (severe); CESC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg00908189 chr16:619842 PIGQ 0.64 8.94 0.48 6.68e-17 Height; CESC cis rs17818399 0.547 rs7607633 chr2:46759427 T/C cg02822958 chr2:46747628 ATP6V1E2 0.45 5.21 0.3 3.77e-7 Height; CESC cis rs6500395 0.788 rs12446280 chr16:48651171 G/T cg04672837 chr16:48644449 N4BP1 0.47 5.58 0.32 5.79e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs61931739 0.500 rs7310237 chr12:34483435 G/A cg06521331 chr12:34319734 NA -0.37 -5.05 -0.3 8.21e-7 Morning vs. evening chronotype; CESC cis rs2573652 0.722 rs11858932 chr15:100542763 G/A cg09918751 chr15:100517450 ADAMTS17 -0.34 -6.26 -0.36 1.53e-9 Height; CESC cis rs12530845 0.623 rs73721662 chr7:135341314 G/A cg23117316 chr7:135346802 PL-5283 -0.58 -6.53 -0.37 3.25e-10 Red blood cell traits; CESC cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg12923728 chr3:195709715 SDHAP1 0.39 5.42 0.32 1.32e-7 Bronchopulmonary dysplasia; CESC cis rs7208859 0.673 rs56085216 chr17:29217234 T/C cg19761014 chr17:28927070 LRRC37B2 0.64 5.35 0.31 1.95e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11074549 chr14:75642944 TMED10 0.65 7.33 0.41 2.76e-12 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs9687898 chr5:253952 A/G cg20965017 chr5:231967 SDHA -0.47 -5.22 -0.31 3.61e-7 Breast cancer; CESC trans rs853679 0.607 rs13203816 chr6:28079598 T/C cg01620082 chr3:125678407 NA -0.81 -6.34 -0.36 1.01e-9 Depression; CESC cis rs12681366 0.663 rs1561648 chr8:95474437 C/T cg13257157 chr8:95487014 RAD54B 0.39 5.34 0.31 2.04e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs10129255 0.500 rs4774189 chr14:107176517 G/T cg07958169 chr14:107095056 NA -0.51 -7.95 -0.44 5.56e-14 Kawasaki disease; CESC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg25036284 chr2:26402008 FAM59B 0.86 9.4 0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs1580019 0.563 rs896137 chr7:32579345 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.45 0.37 5.36e-10 Cognitive ability; CESC cis rs67311347 0.866 rs56331709 chr3:40356558 A/C cg09455208 chr3:40491958 NA 0.45 7.62 0.42 4.58e-13 Renal cell carcinoma; CESC cis rs754466 0.830 rs61854186 chr10:79703255 G/A cg17075019 chr10:79541650 NA -0.68 -8.27 -0.45 6.72e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs15676 0.947 rs2280842 chr9:131585808 C/G cg00228799 chr9:131580591 ENDOG 0.45 5.66 0.33 4.03e-8 Blood metabolite levels; CESC cis rs75477785 1.000 rs11119348 chr1:209989729 A/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs2404602 0.692 rs2120108 chr15:76869929 G/T cg22467129 chr15:76604101 ETFA 0.35 5.21 0.3 3.84e-7 Blood metabolite levels; CESC cis rs6088590 0.687 rs13044899 chr20:33287078 G/A cg08999081 chr20:33150536 PIGU 0.6 9.38 0.5 3.17e-18 Coronary artery disease; CESC cis rs965469 1.000 rs6133036 chr20:3349682 A/G cg25506879 chr20:3388711 C20orf194 -0.57 -6.01 -0.35 5.96e-9 IFN-related cytopenia; CESC cis rs501120 0.925 rs1657344 chr10:44781234 C/T cg09554077 chr10:44749378 NA 0.61 5.51 0.32 8.67e-8 Coronary artery disease;Coronary heart disease; CESC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg07677032 chr17:61819896 STRADA 0.42 5.27 0.31 2.83e-7 Height; CESC cis rs12682352 0.602 rs4841044 chr8:8664940 A/G cg06636001 chr8:8085503 FLJ10661 -0.41 -5.2 -0.3 4.05e-7 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12401058 chr13:23423130 NA -0.51 -6.25 -0.36 1.67e-9 Gut microbiome composition (summer); CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg05657792 chr17:6899758 ALOX12 -0.39 -6.8 -0.39 7.06e-11 Tonsillectomy; CESC cis rs17125944 0.505 rs17125746 chr14:53236079 C/T cg13660082 chr14:53194042 PSMC6 -0.68 -6.17 -0.35 2.48e-9 Alzheimer's disease (late onset); CESC cis rs748404 0.697 rs530683 chr15:43568999 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.52 -7.83 -0.43 1.19e-13 Lung cancer; CESC cis rs7756236 0.521 rs6936993 chr6:36626322 C/T cg08179530 chr6:36648295 CDKN1A -0.37 -5.27 -0.31 2.85e-7 QRS duration; CESC cis rs6582630 0.538 rs8189550 chr12:38333058 T/G cg26384229 chr12:38710491 ALG10B -0.46 -6.0 -0.35 6.62e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs35110281 0.805 rs3788062 chr21:44991159 C/T cg04455712 chr21:45112962 RRP1B 0.37 5.5 0.32 9.16e-8 Mean corpuscular volume; CESC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg07936489 chr17:37558343 FBXL20 0.82 12.01 0.59 8.29e-27 Glomerular filtration rate (creatinine); CESC cis rs2290720 0.804 rs1457564 chr12:101761867 G/T cg22051763 chr12:101673672 UTP20 -0.46 -5.49 -0.32 9.26e-8 Brain structure (hippocampal volume); CESC cis rs2404618 0.561 rs4242536 chr8:1477225 A/G cg13402656 chr8:1511478 DLGAP2 -0.51 -7.22 -0.41 5.55e-12 Lung cancer; CESC cis rs8114671 0.562 rs6088621 chr20:33418740 C/T cg06115741 chr20:33292138 TP53INP2 0.5 5.98 0.34 7.07e-9 Height; CESC cis rs6580649 0.941 rs7957764 chr12:48429701 C/T cg05342945 chr12:48394962 COL2A1 0.54 6.22 0.36 1.96e-9 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23006133 chr5:10563856 ANKRD33B 0.53 6.1 0.35 3.84e-9 Gut microbiome composition (summer); CESC cis rs4450798 0.793 rs60991429 chr3:13751113 G/A cg23332027 chr3:13681764 NA 0.41 5.5 0.32 9.05e-8 Bipolar disorder with mood-incongruent psychosis; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G ch.15.1141100F chr15:72509144 PKM2 0.46 6.17 0.35 2.53e-9 Neuroticism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24641125 chr21:40721130 HMGN1 0.45 6.11 0.35 3.48e-9 Fibrinogen levels; CESC cis rs6433857 0.534 rs1157535 chr2:181361736 T/A cg23363182 chr2:181467187 NA -0.42 -5.82 -0.34 1.68e-8 Body mass index; CESC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg03033257 chr22:50311977 ALG12;CRELD2 0.5 5.12 0.3 5.99e-7 Schizophrenia; CESC cis rs662064 0.748 rs12375 chr1:10596341 C/T cg20482658 chr1:10539492 PEX14 0.41 8.39 0.46 2.91e-15 Asthma; CESC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg20503657 chr10:835505 NA 1.09 10.01 0.52 3.32e-20 Eosinophil percentage of granulocytes; CESC cis rs11059919 1 rs11059919 chr12:129289190 G/A cg09035930 chr12:129282057 SLC15A4 0.75 10.18 0.53 9.25e-21 Systemic lupus erythematosus; CESC cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg07636037 chr3:49044803 WDR6 1.03 18.76 0.76 1.49e-50 Parkinson's disease; CESC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg14983838 chr19:29218262 NA 0.51 6.13 0.35 3.09e-9 Methadone dose in opioid dependence; CESC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg20151795 chr6:28129481 ZNF389 0.42 5.33 0.31 2.11e-7 Depression; CESC cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg05347473 chr6:146136440 FBXO30 0.56 7.19 0.4 6.72e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7959452 0.535 rs7135092 chr12:69658330 T/C cg20891283 chr12:69753455 YEATS4 0.76 11.37 0.57 1.16e-24 Blood protein levels; CESC cis rs10791323 0.720 rs2851117 chr11:133705905 A/G cg15485101 chr11:133734466 NA -0.36 -5.51 -0.32 8.43e-8 Childhood ear infection; CESC cis rs3733585 0.699 rs11724510 chr4:9958583 C/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.91 -0.59 1.82e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6598955 0.543 rs60433268 chr1:26548055 A/C cg04990556 chr1:26633338 UBXN11 0.81 9.26 0.49 7.47e-18 Obesity-related traits; CESC cis rs9915657 0.933 rs4793272 chr17:70139257 A/T cg06234051 chr17:70120541 SOX9 -0.38 -5.72 -0.33 2.93e-8 Thyroid hormone levels; CESC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg27121462 chr16:89883253 FANCA -0.49 -5.76 -0.33 2.38e-8 Vitiligo; CESC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg06155833 chr10:135232936 MTG1 -0.4 -6.27 -0.36 1.5e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CESC cis rs3806843 0.648 rs2530233 chr5:140082876 A/G cg26395211 chr5:140044315 WDR55 0.48 6.15 0.35 2.79e-9 Depressive symptoms (multi-trait analysis); CESC cis rs722599 0.847 rs2058919 chr14:75310812 C/G cg08847533 chr14:75593920 NEK9 -0.44 -5.87 -0.34 1.27e-8 IgG glycosylation; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg02949421 chr12:104359331 TDG -0.46 -6.05 -0.35 4.85e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7949030 0.590 rs12225213 chr11:62350248 T/A cg22862634 chr11:62369728 EML3;MTA2 0.58 8.0 0.44 3.87e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs4835473 0.932 rs7670010 chr4:144742832 A/G cg25736465 chr4:144833511 NA 0.43 6.62 0.38 1.99e-10 Immature fraction of reticulocytes; CESC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg19163074 chr7:65112434 INTS4L2 0.43 5.48 0.32 1.01e-7 Aortic root size; CESC cis rs9926296 0.744 rs164749 chr16:89708224 A/C cg03605463 chr16:89740564 NA 0.59 7.63 0.42 4.24e-13 Vitiligo; CESC cis rs6963495 0.818 rs73192124 chr7:105171528 C/T cg13798780 chr7:105162888 PUS7 0.77 7.87 0.44 9.18e-14 Bipolar disorder (body mass index interaction); CESC cis rs1215050 0.669 rs783962 chr4:98884473 G/A cg05340658 chr4:99064831 C4orf37 -0.45 -5.77 -0.33 2.19e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs897984 0.806 rs1046276 chr16:30914626 A/G cg02466173 chr16:30829666 NA 0.49 7.82 0.43 1.24e-13 Dementia with Lewy bodies; CESC cis rs7599312 0.534 rs7355673 chr2:213404389 T/C cg16329650 chr2:213403929 ERBB4 0.58 8.43 0.46 2.31e-15 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg05872129 chr22:39784769 NA 0.82 11.4 0.57 9.25e-25 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9486715 1.000 rs6902835 chr6:97063005 C/G cg06623918 chr6:96969491 KIAA0776 -0.88 -13.13 -0.63 1.18e-30 Headache; CESC cis rs643506 1.000 rs643506 chr11:111636627 T/G cg09085632 chr11:111637200 PPP2R1B 0.53 6.83 0.39 5.7e-11 Breast cancer; CESC cis rs5417 0.689 rs55868524 chr17:7170665 G/A cg25256661 chr17:7137939 DVL2 -0.55 -7.3 -0.41 3.41e-12 Diastolic blood pressure; CESC cis rs6460942 1.000 rs17668923 chr7:12302873 A/T cg06484146 chr7:12443880 VWDE -0.61 -6.96 -0.39 2.6e-11 Coronary artery disease; CESC cis rs2354432 0.556 rs66501488 chr1:146853992 T/C cg25205988 chr1:146714368 CHD1L -1.03 -8.43 -0.46 2.28e-15 Mitochondrial DNA levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09305948 chr7:5254072 WIPI2 -0.53 -6.11 -0.35 3.47e-9 Gut microbiome composition (summer); CESC cis rs2635047 0.542 rs2668768 chr18:44783447 A/T cg24371990 chr18:44770781 NA 0.35 5.72 0.33 2.84e-8 Educational attainment; CESC cis rs2463822 0.669 rs72919493 chr11:62049651 C/A cg06239285 chr11:62104954 ASRGL1 -1.12 -8.86 -0.48 1.15e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs559928 0.606 rs12419038 chr11:63912736 A/G cg05555928 chr11:63887634 MACROD1 -0.5 -5.34 -0.31 1.98e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg07936489 chr17:37558343 FBXL20 0.79 11.58 0.58 2.25e-25 Glomerular filtration rate (creatinine); CESC cis rs72781680 0.611 rs72797824 chr2:24356456 T/G cg20701182 chr2:24300061 SF3B14 0.92 10.54 0.54 6.23e-22 Lymphocyte counts; CESC cis rs863345 0.604 rs1342946 chr1:158453187 C/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.13 -0.4 9.28e-12 Pneumococcal bacteremia; CESC cis rs12479064 0.703 rs28382977 chr2:100018304 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -7.06 -0.4 1.42e-11 Chronic sinus infection; CESC cis rs6963495 0.818 rs117845382 chr7:105152040 T/C cg13798780 chr7:105162888 PUS7 0.76 7.77 0.43 1.79e-13 Bipolar disorder (body mass index interaction); CESC cis rs4950322 0.570 rs72692917 chr1:146776087 A/T cg16700924 chr1:146552102 NA -0.41 -5.1 -0.3 6.37e-7 Protein quantitative trait loci; CESC cis rs7254114 0.686 rs7249565 chr19:11302807 C/T cg02815516 chr19:11306319 KANK2 -0.4 -6.67 -0.38 1.52e-10 Immature fraction of reticulocytes; CESC cis rs1434579 0.572 rs926052 chr19:44952236 A/T cg15540054 chr19:45004280 ZNF180 0.5 6.2 0.36 2.11e-9 Tuberculosis; CESC cis rs2439831 0.850 rs3742982 chr15:44176681 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.57 5.13 0.3 5.52e-7 Lung cancer in ever smokers; CESC cis rs3749237 0.595 rs3870337 chr3:49557095 G/T cg03060546 chr3:49711283 APEH 0.76 11.77 0.59 5.42e-26 Resting heart rate; CESC cis rs6424115 0.830 rs2502995 chr1:24199290 T/C cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC cis rs727505 0.954 rs28638102 chr7:124499480 A/C cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs55871839 0.684 rs4738729 chr8:59808617 T/C cg07426533 chr8:59803705 TOX -0.44 -6.41 -0.37 6.57e-10 Pneumonia; CESC cis rs71403859 0.730 rs35390364 chr16:71740049 A/G cg08717414 chr16:71523259 ZNF19 -0.68 -5.42 -0.32 1.37e-7 Post bronchodilator FEV1; CESC cis rs9911578 1.000 rs12453049 chr17:56611372 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC cis rs6502050 0.835 rs4247357 chr17:80166989 G/T cg23985595 chr17:80112537 CCDC57 -0.39 -6.24 -0.36 1.76e-9 Life satisfaction; CESC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg11663144 chr21:46675770 NA -0.62 -9.82 -0.52 1.27e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg08470875 chr2:26401718 FAM59B 0.74 7.87 0.44 9.35e-14 Gut microbiome composition (summer); CESC cis rs1030877 1.000 rs2576743 chr2:105901337 C/T cg02079111 chr2:105885981 TGFBRAP1 0.67 10.23 0.53 6.49e-21 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23203755 chr3:149182974 NA -0.61 -7.32 -0.41 3e-12 Gut microbiome composition (summer); CESC cis rs7949030 0.588 rs2428549 chr11:62312394 A/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.39 -5.33 -0.31 2.12e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2070488 0.574 rs57754356 chr3:38488706 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 12.46 0.61 2.36e-28 Electrocardiographic conduction measures; CESC cis rs9560113 0.580 rs9560116 chr13:112193731 G/A cg10483660 chr13:112241077 NA 0.4 6.56 0.37 2.74e-10 Menarche (age at onset); CESC cis rs863345 0.967 rs4411130 chr1:158530665 C/T cg12129480 chr1:158549410 OR10X1 0.35 7.22 0.41 5.45e-12 Pneumococcal bacteremia; CESC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg18876405 chr7:65276391 NA -0.54 -7.59 -0.42 5.49e-13 Aortic root size; CESC cis rs698813 0.703 rs2053457 chr2:44572164 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.53 6.19 0.36 2.28e-9 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2288912 0.872 rs9304646 chr19:45450408 T/C cg09555818 chr19:45449301 APOC2 0.43 6.72 0.38 1.08e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2412488 0.815 rs6843529 chr4:54355854 T/C cg22241045 chr4:54363911 LNX1 -0.38 -5.32 -0.31 2.19e-7 DNA methylation (variation); CESC cis rs1941023 0.584 rs2197236 chr11:60168859 T/C cg08716584 chr11:60157161 MS4A7 -0.55 -9.03 -0.48 3.7e-17 Congenital heart disease (maternal effect); CESC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg26314531 chr2:26401878 FAM59B -0.64 -7.3 -0.41 3.29e-12 Gut microbiome composition (summer); CESC cis rs727505 0.721 rs56069273 chr7:124768604 G/A cg23710748 chr7:124431027 NA -0.34 -5.71 -0.33 3.05e-8 Lewy body disease; CESC cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs4660261 0.561 rs11210934 chr1:44369435 G/A cg23954153 chr1:44402353 ARTN -0.35 -5.58 -0.32 6.05e-8 Intelligence (multi-trait analysis); CESC cis rs360798 0.532 rs12994674 chr2:62996645 G/A cg17519650 chr2:63277830 OTX1 -0.58 -7.33 -0.41 2.76e-12 Coronary artery disease; CESC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs5747327 0.771 rs5746453 chr22:18137274 C/T cg19898043 chr22:18121309 BCL2L13 -0.4 -5.09 -0.3 6.74e-7 Myeloid white cell count;Granulocyte count; CESC cis rs2115536 0.720 rs12916091 chr15:80222572 T/G cg11839771 chr15:80205821 ST20 -0.35 -5.14 -0.3 5.45e-7 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs34779708 0.736 rs34195979 chr10:35549817 T/C cg03585969 chr10:35415529 CREM 0.54 6.14 0.35 2.97e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs2243480 0.803 rs36004293 chr7:65416512 T/C cg25894440 chr7:65020034 NA -0.59 -5.23 -0.31 3.41e-7 Diabetic kidney disease; CESC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg08027265 chr7:2291960 NA -0.43 -6.82 -0.39 6.08e-11 Bipolar disorder and schizophrenia; CESC cis rs7607369 0.719 rs12613545 chr2:219623504 C/T cg02176678 chr2:219576539 TTLL4 -0.44 -7.68 -0.43 3.02e-13 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs6032067 0.929 rs876835 chr20:43827241 T/C cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.53e-7 Blood protein levels; CESC cis rs9486719 0.894 rs34826652 chr6:96899085 A/G cg18709589 chr6:96969512 KIAA0776 -0.54 -5.87 -0.34 1.3e-8 Migraine;Coronary artery disease; CESC cis rs12497850 0.644 rs11928552 chr3:48739883 T/C cg03060546 chr3:49711283 APEH 0.44 5.22 0.31 3.54e-7 Parkinson's disease; CESC cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg05585544 chr11:47624801 NA -0.53 -8.07 -0.44 2.41e-14 Subjective well-being; CESC cis rs7223966 1.000 rs2854223 chr17:61939014 A/G cg11494091 chr17:61959527 GH2 0.39 5.53 0.32 7.54e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg18252515 chr7:66147081 NA 0.43 5.73 0.33 2.76e-8 Aortic root size; CESC cis rs1005277 0.505 rs13503 chr10:38239843 C/A cg00409905 chr10:38381863 ZNF37A 0.57 8.02 0.44 3.33e-14 Extrinsic epigenetic age acceleration; CESC cis rs636291 0.517 rs55935829 chr1:10540926 A/T cg07384165 chr1:10488281 NA -0.59 -8.64 -0.47 5.48e-16 Prostate cancer; CESC cis rs9790314 1.000 rs336570 chr3:161072054 A/G cg03342759 chr3:160939853 NMD3 0.53 7.01 0.4 1.97e-11 Morning vs. evening chronotype; CESC cis rs2299587 0.500 rs7815785 chr8:17730338 T/C cg08627089 chr8:17753878 FGL1 -0.39 -5.53 -0.32 7.86e-8 Economic and political preferences; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19238398 chr5:138775248 DNAJC18 0.61 7.4 0.41 1.79e-12 Gut microbiome composition (summer); CESC cis rs9291683 0.588 rs6844329 chr4:10018544 T/C cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.51e-12 Bone mineral density; CESC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg27532560 chr4:187881888 NA -0.39 -6.0 -0.35 6.42e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs6732160 1.000 rs6732160 chr2:73387228 A/G cg01422370 chr2:73384389 NA 0.5 8.63 0.47 5.72e-16 Intelligence (multi-trait analysis); CESC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg06481639 chr22:41940642 POLR3H -0.58 -6.4 -0.37 6.86e-10 Vitiligo; CESC cis rs6964587 0.621 rs38799 chr7:92045139 C/T cg17063962 chr7:91808500 NA -0.53 -7.72 -0.43 2.34e-13 Breast cancer; CESC cis rs2860975 0.580 rs11572120 chr10:96815303 A/C cg09036531 chr10:96991505 NA -0.37 -5.29 -0.31 2.56e-7 Immune response to smallpox vaccine (IL-6); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg06488097 chr7:17921523 SNX13 0.39 6.5 0.37 3.9e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8067545 0.586 rs2526463 chr17:20078297 G/A cg13482628 chr17:19912719 NA -0.44 -5.83 -0.34 1.58e-8 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06565220 chr1:112938731 CTTNBP2NL 0.5 6.28 0.36 1.4e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg06808227 chr14:105710500 BRF1 0.53 6.06 0.35 4.62e-9 Mean platelet volume;Platelet distribution width; CESC cis rs3820928 0.839 rs13413292 chr2:227893747 G/C cg05526886 chr2:227700861 RHBDD1 -0.45 -5.73 -0.33 2.68e-8 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20594519 chr1:145611013 POLR3C;RNF115 0.53 6.26 0.36 1.53e-9 Gut microbiome composition (summer); CESC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg24250549 chr1:154909240 PMVK 0.72 10.85 0.55 6.34e-23 Prostate cancer; CESC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg25985355 chr7:65971099 NA -0.31 -5.04 -0.3 8.76e-7 Aortic root size; CESC cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.03 0.3 9.17e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11098499 0.644 rs3806808 chr4:120551085 A/C cg25214090 chr10:38739885 LOC399744 0.62 8.74 0.47 2.74e-16 Corneal astigmatism; CESC cis rs9399135 0.967 rs4896119 chr6:135293391 C/T cg24558204 chr6:135376177 HBS1L 0.51 6.77 0.38 8.17e-11 Red blood cell count; CESC cis rs6456156 0.565 rs6456153 chr6:167472167 T/C cg07741184 chr6:167504864 NA 0.36 6.21 0.36 2.01e-9 Primary biliary cholangitis; CESC cis rs854765 0.547 rs9912096 chr17:17896673 A/C cg04398451 chr17:18023971 MYO15A -0.71 -10.4 -0.54 1.75e-21 Total body bone mineral density; CESC cis rs926938 0.521 rs360649 chr1:115439668 G/C cg12756093 chr1:115239321 AMPD1 0.45 6.13 0.35 3.25e-9 Autism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02760766 chr15:72668543 HEXA;C15orf34 -0.51 -6.05 -0.35 4.89e-9 Ulcerative colitis; CESC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg02038168 chr22:39784481 NA -0.61 -7.67 -0.43 3.23e-13 Intelligence (multi-trait analysis); CESC cis rs6088590 0.582 rs6059909 chr20:33139691 C/A cg24642439 chr20:33292090 TP53INP2 0.61 8.08 0.44 2.27e-14 Coronary artery disease; CESC cis rs6032067 0.636 rs6104093 chr20:43908297 T/C cg10761708 chr20:43804764 PI3 0.43 5.52 0.32 8.23e-8 Blood protein levels; CESC cis rs1023500 0.573 rs133381 chr22:42470608 C/G cg04733989 chr22:42467013 NAGA 0.82 12.06 0.6 5.34e-27 Schizophrenia; CESC cis rs7089973 0.604 rs7923693 chr10:116619566 A/G cg25233709 chr10:116636983 FAM160B1 0.4 6.61 0.38 2.08e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg24209194 chr3:40518798 ZNF619 0.52 6.78 0.38 7.89e-11 Renal cell carcinoma; CESC cis rs6424115 1.000 rs7514394 chr1:24100223 A/G cg10978503 chr1:24200527 CNR2 -0.25 -5.03 -0.3 9.15e-7 Immature fraction of reticulocytes; CESC cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.5 0.46 1.36e-15 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06514377 chr2:3320918 TSSC1 0.48 6.24 0.36 1.68e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7824557 0.507 rs7010590 chr8:11062882 C/T cg06636001 chr8:8085503 FLJ10661 0.57 7.47 0.42 1.18e-12 Retinal vascular caliber; CESC cis rs7100689 0.577 rs2342813 chr10:82046302 T/G cg00277334 chr10:82204260 NA -0.53 -6.96 -0.39 2.64e-11 Post bronchodilator FEV1; CESC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC trans rs66573146 1.000 rs7686168 chr4:6986057 C/A cg07817883 chr1:32538562 TMEM39B 1.48 9.1 0.49 2.16e-17 Granulocyte percentage of myeloid white cells; CESC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg06740227 chr12:86229804 RASSF9 0.37 5.05 0.3 8.19e-7 Major depressive disorder; CESC cis rs757110 0.900 rs2074314 chr11:17411821 C/T cg15432903 chr11:17409602 KCNJ11 0.67 9.5 0.5 1.32e-18 Type 2 diabetes; CESC cis rs7927771 0.524 rs11039329 chr11:47684908 A/G cg20307385 chr11:47447363 PSMC3 0.63 8.77 0.47 2.21e-16 Subjective well-being; CESC cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg05340658 chr4:99064831 C4orf37 0.75 10.87 0.56 5.36e-23 Colonoscopy-negative controls vs population controls; CESC cis rs3816788 0.774 rs11784816 chr8:21773500 C/T cg17168535 chr8:21777572 XPO7 -0.65 -9.9 -0.52 7.47e-20 Lung cancer in ever smokers; CESC cis rs9914988 0.943 rs2043031 chr17:27085564 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.29 -0.31 2.56e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs561341 0.941 rs2470236 chr17:30304940 G/C cg00745463 chr17:30367425 LRRC37B -0.66 -6.7 -0.38 1.25e-10 Hip circumference adjusted for BMI; CESC trans rs526821 0.595 rs532278 chr11:55344983 A/G cg15704280 chr7:45808275 SEPT13 -0.53 -6.57 -0.37 2.61e-10 Pediatric bone mineral density (spine); CESC cis rs9611565 0.512 rs5758465 chr22:42175314 T/C cg03806693 chr22:41940476 POLR3H 1.17 13.6 0.64 2.7e-32 Vitiligo; CESC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg11890956 chr21:40555474 PSMG1 -0.62 -8.57 -0.47 8.5e-16 Menarche (age at onset); CESC cis rs7296418 0.663 rs11057276 chr12:123820397 C/T cg00376283 chr12:123451042 ABCB9 -0.55 -7.67 -0.43 3.2e-13 Platelet count; CESC cis rs7191439 0.626 rs8059794 chr16:88787388 C/T cg02389323 chr16:88786976 FAM38A 0.85 7.33 0.41 2.87e-12 Plateletcrit; CESC trans rs11098499 1.000 rs10029750 chr4:120172543 A/G cg25214090 chr10:38739885 LOC399744 0.64 8.53 0.46 1.16e-15 Corneal astigmatism; CESC trans rs1545843 0.538 rs10779090 chr12:84759829 A/G cg03015433 chr16:56623111 MT3 0.34 6.17 0.35 2.48e-9 Major depressive disorder; CESC cis rs926938 0.563 rs360661 chr1:115455280 G/A cg12756093 chr1:115239321 AMPD1 0.48 6.97 0.39 2.58e-11 Autism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13883984 chr15:83621779 HOMER2 0.45 6.33 0.36 1.04e-9 Gut microbiota (bacterial taxa); CESC cis rs6496667 0.533 rs2589949 chr15:90955015 C/T cg10434728 chr15:90938212 IQGAP1 0.31 5.49 0.32 9.53e-8 Rheumatoid arthritis; CESC cis rs61931739 0.500 rs10844846 chr12:34394611 C/G cg23762105 chr12:34175262 ALG10 -0.39 -5.14 -0.3 5.26e-7 Morning vs. evening chronotype; CESC cis rs5770917 0.522 rs8142477 chr22:51011376 G/C cg25309564 chr22:51001381 C22orf41 0.55 6.15 0.35 2.79e-9 Narcolepsy; CESC cis rs7605827 0.897 rs7572509 chr2:15597288 C/T cg19274914 chr2:15703543 NA 0.32 5.6 0.33 5.41e-8 Educational attainment (years of education); CESC cis rs1461503 0.966 rs1461502 chr11:122844927 C/G cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs7666738 0.830 rs13136930 chr4:98937933 A/T cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs11601602 0.576 rs12576396 chr11:28555952 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.6 7.48 0.42 1.06e-12 Obesity-related traits; CESC cis rs9660992 0.762 rs1172137 chr1:205246061 G/T cg21643547 chr1:205240462 TMCC2 -0.47 -7.39 -0.41 1.96e-12 Mean corpuscular volume;Mean platelet volume; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23731836 chr8:29120779 KIF13B -0.53 -7.29 -0.41 3.65e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs853679 0.769 rs7752608 chr6:28301195 A/G cg06606381 chr12:133084897 FBRSL1 -0.73 -6.67 -0.38 1.52e-10 Depression; CESC cis rs11098499 0.909 rs28632018 chr4:120386730 T/C cg09307838 chr4:120376055 NA 0.95 13.96 0.65 1.42e-33 Corneal astigmatism; CESC cis rs2735413 0.958 rs11150034 chr16:78066369 G/A cg04733911 chr16:78082701 NA -0.49 -7.7 -0.43 2.75e-13 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg22823121 chr1:150693482 HORMAD1 0.4 5.53 0.32 7.83e-8 Melanoma; CESC cis rs1215050 0.791 rs11729826 chr4:98657190 G/T cg05340658 chr4:99064831 C4orf37 -0.47 -6.04 -0.35 5.08e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1707322 0.927 rs11211194 chr1:46282084 C/T cg05343316 chr1:45956843 TESK2 0.44 5.53 0.32 7.85e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11122272 0.735 rs2491407 chr1:231518928 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs8114671 0.836 rs6142280 chr20:33622242 A/C cg06115741 chr20:33292138 TP53INP2 -0.46 -5.57 -0.32 6.36e-8 Height; CESC cis rs1878931 0.517 rs17685105 chr16:3413749 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.91 -13.09 -0.63 1.54e-30 Body mass index (adult); CESC cis rs1559088 0.948 rs12460195 chr19:33584479 G/A cg27124370 chr19:33622961 WDR88 0.45 6.0 0.35 6.49e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs17539620 0.624 rs111484697 chr6:154838903 A/G cg20019720 chr6:154832845 CNKSR3 0.45 5.61 0.33 5.2100000000000003e-08 Lipoprotein (a) levels; CESC cis rs3015497 0.603 rs1060197 chr14:51057727 A/G cg26011998 chr14:51135199 SAV1 0.45 5.22 0.31 3.6e-7 Mean platelet volume; CESC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.12 0.4 1.04e-11 Height; CESC cis rs11871801 0.517 rs668799 chr17:40716235 C/T cg14558262 chr17:40713999 COASY 0.5 5.84 0.34 1.53e-8 Crohn's disease; CESC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.43 -5.06 -0.3 8e-7 Breast cancer; CESC cis rs2963155 0.518 rs9324918 chr5:142767160 T/C cg17617527 chr5:142782415 NR3C1 0.82 7.43 0.42 1.48e-12 Breast cancer; CESC cis rs6693567 0.565 rs834243 chr1:150339290 C/A cg09579323 chr1:150459698 TARS2 0.46 6.05 0.35 4.93e-9 Migraine; CESC cis rs7296418 0.630 rs11608305 chr12:123791165 C/G cg00376283 chr12:123451042 ABCB9 0.59 8.18 0.45 1.19e-14 Platelet count; CESC cis rs35160687 0.644 rs2113615 chr2:86517602 G/A cg01119172 chr2:86362222 SNORD94;PTCD3 -0.38 -5.1 -0.3 6.57e-7 Night sleep phenotypes; CESC cis rs2302190 0.882 rs6503869 chr17:56637461 C/G cg25885038 chr17:56607967 SEPT4 -0.4 -5.43 -0.32 1.27e-7 Vitamin D levels; CESC cis rs10911232 0.507 rs6660111 chr1:183014289 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 13.22 0.63 5.29e-31 Hypertriglyceridemia; CESC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg22800045 chr5:56110881 MAP3K1 0.59 7.78 0.43 1.58e-13 Initial pursuit acceleration; CESC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg20151795 chr6:28129481 ZNF389 0.45 5.92 0.34 9.77e-9 Depression; CESC cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg04414720 chr1:150670196 GOLPH3L -0.37 -5.19 -0.3 4.14e-7 Tonsillectomy; CESC cis rs6570726 0.846 rs397311 chr6:145806701 C/T cg05347473 chr6:146136440 FBXO30 -0.49 -6.5 -0.37 3.9e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs5769707 0.609 rs135861 chr22:49998118 A/G cg20744362 chr22:50050164 C22orf34 0.37 5.44 0.32 1.18e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs9925964 0.933 rs9939417 chr16:31053467 C/T cg02466173 chr16:30829666 NA 0.34 5.24 0.31 3.3e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7246657 0.943 rs10407084 chr19:37907792 T/C cg23950597 chr19:37808831 NA -0.61 -6.23 -0.36 1.81e-9 Coronary artery calcification; CESC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.12 -0.4 1.05e-11 Total body bone mineral density; CESC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg04944784 chr2:26401820 FAM59B -0.93 -10.74 -0.55 1.38e-22 Gut microbiome composition (summer); CESC cis rs62458065 0.513 rs702831 chr7:32579715 C/T cg20159608 chr7:32802032 NA -0.55 -6.15 -0.35 2.89e-9 Metabolite levels (HVA/MHPG ratio); CESC cis rs8027181 1.000 rs2162269 chr15:73090262 C/T cg25632853 chr15:73088954 NA 0.36 6.45 0.37 5.23e-10 Triglyceride levels; CESC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.57 0.64 3.26e-32 Prudent dietary pattern; CESC trans rs1814175 0.791 rs7395713 chr11:49877887 A/G cg03929089 chr4:120376271 NA -0.91 -15.43 -0.69 9.49e-39 Height; CESC cis rs1595825 0.891 rs77946222 chr2:198533251 C/T cg00982548 chr2:198649783 BOLL -0.48 -5.14 -0.3 5.44e-7 Ulcerative colitis; CESC cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg19193384 chr17:30244184 NA -0.69 -6.51 -0.37 3.73e-10 Hip circumference adjusted for BMI; CESC cis rs1707322 0.717 rs2991989 chr1:46082965 C/T cg05343316 chr1:45956843 TESK2 -0.53 -6.5 -0.37 3.98e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs28374715 0.532 rs11070328 chr15:41651569 T/C cg18705301 chr15:41695430 NDUFAF1 -1.04 -16.61 -0.71 6.09e-43 Ulcerative colitis; CESC cis rs6964587 0.626 rs10266424 chr7:91503228 C/T cg17063962 chr7:91808500 NA -0.46 -6.39 -0.37 7.32e-10 Breast cancer; CESC cis rs829883 0.659 rs10860342 chr12:98941223 C/T cg25150519 chr12:98850993 NA 0.63 7.37 0.41 2.11e-12 Colorectal adenoma (advanced); CESC cis rs2749592 0.550 rs10764135 chr10:37866845 C/T cg25427524 chr10:38739819 LOC399744 0.55 7.63 0.42 4.22e-13 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg00684032 chr4:1343700 KIAA1530 0.61 9.14 0.49 1.66e-17 Obesity-related traits; CESC cis rs1707322 0.716 rs28375469 chr1:46195375 T/C cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs793571 0.544 rs11638244 chr15:58907151 A/T cg05156742 chr15:59063176 FAM63B 0.81 11.73 0.58 7.22e-26 Schizophrenia; CESC cis rs6866344 0.697 rs62392823 chr5:178126968 T/C cg03877680 chr5:178157825 ZNF354A 0.75 8.48 0.46 1.59e-15 Neutrophil percentage of white cells; CESC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 10.98 0.56 2.23e-23 Alzheimer's disease; CESC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg24562669 chr7:97807699 LMTK2 0.51 7.57 0.42 6.13e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs965513 1.000 rs7847663 chr9:100544868 C/T cg13688889 chr9:100608707 NA -0.61 -8.54 -0.46 1.06e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.54 -5.73 -0.33 2.72e-8 Schizophrenia; CESC cis rs10489525 0.599 rs34710929 chr1:115606608 G/A cg01522456 chr1:115632236 TSPAN2 0.48 5.82 0.34 1.7e-8 Autism; CESC cis rs6866344 0.697 rs11739893 chr5:178127837 G/A cg10224037 chr5:178157518 ZNF354A 0.68 7.46 0.42 1.24e-12 Neutrophil percentage of white cells; CESC cis rs7160336 0.515 rs7152352 chr14:74611271 A/G cg05179529 chr14:74551516 LIN52;ALDH6A1 -0.43 -5.26 -0.31 2.93e-7 Blood protein levels; CESC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19069963 chr22:29663643 EWSR1;RHBDD3 0.64 7.46 0.42 1.25e-12 Gut microbiome composition (summer); CESC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg08736216 chr1:53307985 ZYG11A -0.42 -7.06 -0.4 1.46e-11 Monocyte count; CESC cis rs9581857 0.579 rs3759434 chr13:27997700 A/C cg22138327 chr13:27999177 GTF3A 0.73 7.68 0.43 3.08e-13 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs2228479 0.850 rs62054601 chr16:89811751 C/G cg00800038 chr16:89945340 TCF25 -0.88 -7.27 -0.41 4e-12 Skin colour saturation; CESC cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg24110177 chr3:50126178 RBM5 0.52 7.29 0.41 3.61e-12 Intelligence (multi-trait analysis); CESC cis rs17253792 0.822 rs10150498 chr14:56064124 G/T cg01858014 chr14:56050164 KTN1 -0.85 -6.79 -0.38 7.45e-11 Putamen volume; CESC cis rs11209002 0.524 rs2815386 chr1:67541996 A/G cg02640540 chr1:67518911 SLC35D1 0.47 5.39 0.31 1.52e-7 Crohn's disease; CESC cis rs7917772 0.582 rs4917973 chr10:104333700 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.61 0.33 5.05e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs10065369 0.544 rs4476711 chr5:113554595 G/A cg04850370 chr1:32573395 KPNA6 0.71 6.15 0.35 2.85e-9 Night sleep phenotypes; CESC cis rs7656342 0.636 rs1914874 chr4:9839490 C/A cg11266682 chr4:10021025 SLC2A9 -0.34 -5.17 -0.3 4.7e-7 Gut microbiota (bacterial taxa); CESC cis rs72781680 1.000 rs72781653 chr2:24215633 T/C cg08917208 chr2:24149416 ATAD2B 0.94 8.45 0.46 1.99e-15 Lymphocyte counts; CESC cis rs644799 0.965 rs2508713 chr11:95547927 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.13 0.49 1.83e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6728642 0.803 rs11891457 chr2:97632449 G/T cg26665480 chr2:98280029 ACTR1B -0.72 -7.76 -0.43 1.9e-13 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs7586879 0.616 rs876186 chr2:25125585 C/T cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.02e-11 Body mass index; CESC cis rs2070488 0.965 rs2300668 chr3:38540541 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.89 -16.32 -0.71 6.19e-42 Electrocardiographic conduction measures; CESC cis rs2075671 0.903 rs11983334 chr7:100302434 C/T cg16850897 chr7:100343110 ZAN -0.7 -8.84 -0.48 1.38e-16 Other erythrocyte phenotypes; CESC cis rs7829975 0.714 rs6994038 chr8:8660538 C/A cg15556689 chr8:8085844 FLJ10661 0.49 6.27 0.36 1.49e-9 Mood instability; CESC cis rs10789491 0.767 rs1595898 chr1:47193577 G/A cg15501359 chr1:47185051 KIAA0494 0.76 7.41 0.41 1.65e-12 Response to hepatitis C treatment; CESC cis rs3733585 0.775 rs13124007 chr4:10043931 G/C cg02734326 chr4:10020555 SLC2A9 0.45 6.19 0.36 2.29e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs7618501 0.902 rs7645061 chr3:49868842 C/T cg21659725 chr3:3221576 CRBN 0.84 13.68 0.64 1.39e-32 Intelligence (multi-trait analysis); CESC cis rs1185460 0.967 rs1786141 chr11:118938315 C/T cg23280166 chr11:118938394 VPS11 0.6 8.45 0.46 1.92e-15 Coronary artery disease; CESC cis rs7949030 0.588 rs2509982 chr11:62312318 C/T cg22862634 chr11:62369728 EML3;MTA2 0.49 6.89 0.39 4.13e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs523522 0.923 rs1048830 chr12:120882217 G/T cg02849695 chr1:159869960 CCDC19 0.35 6.19 0.36 2.24e-9 High light scatter reticulocyte count; CESC cis rs9916302 0.706 rs439537 chr17:37734482 T/C cg20243544 chr17:37824526 PNMT 0.56 5.47 0.32 1.03e-7 Glomerular filtration rate (creatinine); CESC cis rs62432291 0.681 rs423533 chr6:159664516 G/T cg14500486 chr6:159655392 FNDC1 -0.57 -5.58 -0.32 5.94e-8 Joint mobility (Beighton score); CESC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg10128416 chr1:75198403 TYW3;CRYZ 0.5 6.84 0.39 5.44e-11 Resistin levels; CESC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 12.23 0.6 1.42e-27 Alzheimer's disease; CESC cis rs13102973 0.931 rs4608864 chr4:135883488 G/A cg14419869 chr4:135874104 NA 0.33 5.1 0.3 6.39e-7 Subjective well-being; CESC cis rs60843830 1.000 rs6709534 chr2:217334 G/C cg25945732 chr2:264204 ACP1;SH3YL1 0.85 11.18 0.57 5.09e-24 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg10295955 chr4:187884368 NA -1.08 -23.01 -0.82 4.07e-65 Lobe attachment (rater-scored or self-reported); CESC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.92 10.15 0.53 1.19e-20 Platelet count; CESC cis rs9814567 0.896 rs6763188 chr3:134349995 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 0.32 5.11 0.3 6.06e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7843479 0.965 rs1484162 chr8:21831385 A/G cg17168535 chr8:21777572 XPO7 0.52 7.31 0.41 3.25e-12 Mean corpuscular volume; CESC cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg22862634 chr11:62369728 EML3;MTA2 0.6 8.48 0.46 1.55e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs11688816 0.967 rs6714241 chr2:63069112 G/T cg17519650 chr2:63277830 OTX1 0.42 5.95 0.34 8.43e-9 Body mass index; CESC cis rs854765 0.520 rs9899355 chr17:17898243 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.53 7.02 0.4 1.82e-11 Total body bone mineral density; CESC cis rs6541297 0.703 rs598203 chr1:230322122 C/G cg20703242 chr1:230279135 GALNT2 0.37 5.05 0.3 8.38e-7 Coronary artery disease; CESC cis rs3096299 0.967 rs28689480 chr16:89460093 T/C cg16743903 chr16:89593216 SPG7 -0.43 -5.4 -0.32 1.45e-7 Multiple myeloma (IgH translocation); CESC cis rs12410462 0.748 rs1495853 chr1:227657336 A/G cg23173402 chr1:227635558 NA -0.56 -5.75 -0.33 2.44e-8 Major depressive disorder; CESC cis rs3008870 0.727 rs2862729 chr1:67500828 T/C cg02640540 chr1:67518911 SLC35D1 0.45 5.43 0.32 1.26e-7 Lymphocyte percentage of white cells; CESC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg08888203 chr3:10149979 C3orf24 0.5 6.25 0.36 1.62e-9 Alzheimer's disease; CESC cis rs654950 1.000 rs679449 chr1:41988634 G/T cg06885757 chr1:42089581 HIVEP3 -0.56 -8.44 -0.46 2.06e-15 Airway imaging phenotypes; CESC cis rs7666738 0.791 rs11735105 chr4:98937357 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2294693 0.945 rs9369260 chr6:41010368 C/G cg14769373 chr6:40998127 UNC5CL 0.48 5.83 0.34 1.63e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs2120019 1.000 rs2083731 chr15:75368538 A/C cg09165964 chr15:75287851 SCAMP5 -0.66 -7.99 -0.44 4.25e-14 Blood trace element (Zn levels); CESC cis rs9916302 0.904 rs35335692 chr17:37710006 A/G cg07936489 chr17:37558343 FBXL20 -0.79 -11.2 -0.57 4.43e-24 Glomerular filtration rate (creatinine); CESC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg23985595 chr17:80112537 CCDC57 0.42 6.52 0.37 3.56e-10 Life satisfaction; CESC trans rs2764766 0.789 rs151885 chr5:127169836 A/G cg15764593 chr10:829463 NA 0.4 6.33 0.36 1.06e-9 Schizophrenia; CESC cis rs72634258 0.945 rs397349 chr1:8074872 A/C cg00042356 chr1:8021962 PARK7 0.45 5.11 0.3 6.21e-7 Inflammatory bowel disease; CESC cis rs2576037 0.796 rs2576034 chr18:44588548 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -8.9 -0.48 8.87e-17 Personality dimensions; CESC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg12311346 chr5:56204834 C5orf35 -0.64 -7.96 -0.44 4.98e-14 Initial pursuit acceleration; CESC cis rs752010 0.543 rs1570355 chr1:42042317 C/T cg06885757 chr1:42089581 HIVEP3 0.45 7.27 0.41 3.99e-12 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9902453 0.765 rs3102555 chr17:28044101 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.3 0.53 3.92e-21 Coffee consumption (cups per day); CESC cis rs881375 0.715 rs10760119 chr9:123646060 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.99 0.39 2.29e-11 Rheumatoid arthritis; CESC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC cis rs2997447 0.761 rs17257120 chr1:26450101 A/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.16 0.3 4.74e-7 QRS complex (12-leadsum); CESC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg04166393 chr7:2884313 GNA12 0.62 7.66 0.43 3.44e-13 Height; CESC cis rs644799 1.000 rs500054 chr11:95593806 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.89 12.34 0.6 6.1e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg05872129 chr22:39784769 NA -0.81 -11.37 -0.57 1.19e-24 Intelligence (multi-trait analysis); CESC cis rs6460942 0.915 rs7802454 chr7:12454508 A/G cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs7772486 0.764 rs2265468 chr6:146218346 A/C cg05347473 chr6:146136440 FBXO30 0.56 7.13 0.4 9.67e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6696846 0.749 rs7515178 chr1:205084120 G/A cg00857998 chr1:205179979 DSTYK 0.5 6.85 0.39 5.06e-11 Red blood cell count; CESC cis rs9796 0.727 rs12101934 chr15:41353079 C/T cg18705301 chr15:41695430 NDUFAF1 -0.4 -5.83 -0.34 1.58e-8 Menopause (age at onset); CESC trans rs4689592 0.503 rs11937667 chr4:7057037 C/G cg07817883 chr1:32538562 TMEM39B 0.67 6.36 0.36 8.92e-10 Monocyte percentage of white cells; CESC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs1055129 0.655 rs7223416 chr17:73836162 C/G cg02397686 chr17:73851076 WBP2 0.35 5.12 0.3 5.96e-7 White matter hyperintensity burden; CESC cis rs7188697 0.922 rs28479997 chr16:58614877 G/A cg21335942 chr16:58549945 SETD6 -0.45 -5.24 -0.31 3.34e-7 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14095983 chr9:71737204 TJP2 0.65 7.66 0.43 3.59e-13 Gut microbiome composition (summer); CESC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 4.97e-9 Prudent dietary pattern; CESC cis rs7666738 0.830 rs62318472 chr4:98926030 G/A cg17366294 chr4:99064904 C4orf37 0.58 8.03 0.44 3.26e-14 Colonoscopy-negative controls vs population controls; CESC cis rs7617773 0.963 rs9822496 chr3:48181333 T/C cg11946769 chr3:48343235 NME6 0.61 8.11 0.45 1.84e-14 Coronary artery disease; CESC cis rs5769765 1.000 rs2319458 chr22:50236306 G/A cg26441486 chr22:50317300 CRELD2 0.4 5.4 0.31 1.46e-7 Schizophrenia; CESC cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg03684893 chr10:554711 DIP2C -0.35 -5.12 -0.3 5.9e-7 Psychosis in Alzheimer's disease; CESC cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg05347473 chr6:146136440 FBXO30 0.57 7.21 0.4 5.99e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs11039571 0.588 rs10734564 chr11:48160429 A/G cg15704280 chr7:45808275 SEPT13 -0.64 -6.35 -0.36 9.56e-10 D-dimer levels; CESC cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg03433033 chr1:76189801 ACADM 0.8 12.71 0.62 3.18e-29 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12564526 chr7:66767603 PMS2L4;STAG3L4 0.62 7.54 0.42 7.65e-13 Gut microbiome composition (summer); CESC cis rs8177179 0.904 rs1130459 chr3:133465283 A/G cg24879335 chr3:133465180 TF 0.44 8.37 0.46 3.38e-15 Iron status biomarkers (transferrin levels); CESC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.41 6.22 0.36 1.89e-9 Cystic fibrosis severity; CESC cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg05347473 chr6:146136440 FBXO30 0.56 7.25 0.41 4.62e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9768139 0.708 rs896780 chr7:158113972 C/T cg25566285 chr7:158114605 PTPRN2 0.54 9.06 0.49 2.99e-17 Calcium levels; CESC cis rs17376456 0.825 rs10051878 chr5:93064164 T/G cg25358565 chr5:93447407 FAM172A 1.11 10.66 0.55 2.6e-22 Diabetic retinopathy; CESC cis rs7772486 0.790 rs6923545 chr6:146244743 A/G cg05347473 chr6:146136440 FBXO30 -0.57 -7.31 -0.41 3.07e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs10858047 0.883 rs6701427 chr1:115216886 C/T cg12756093 chr1:115239321 AMPD1 -0.5 -5.14 -0.3 5.34e-7 Autism; CESC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.24 -0.36 1.77e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs5758659 1.000 rs5758659 chr22:42622003 C/T cg04733989 chr22:42467013 NAGA 0.42 5.83 0.34 1.57e-8 Cognitive function; CESC trans rs35110281 0.782 rs1454650 chr21:45012353 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 7.08 0.4 1.29e-11 Mean corpuscular volume; CESC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 11.43 0.57 7.11e-25 Platelet count; CESC trans rs2727020 0.553 rs3907576 chr11:49536639 A/C cg03929089 chr4:120376271 NA -0.81 -12.24 -0.6 1.37e-27 Coronary artery disease; CESC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg11663144 chr21:46675770 NA -0.65 -10.06 -0.53 2.22e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg10351095 chr21:47802916 PCNT 0.42 5.37 0.31 1.74e-7 Testicular germ cell tumor; CESC cis rs7116495 1.000 rs607446 chr11:71789252 G/A cg10381502 chr11:71823885 C11orf51 -0.68 -5.48 -0.32 9.68e-8 Severe influenza A (H1N1) infection; CESC cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg20701182 chr2:24300061 SF3B14 0.93 10.39 0.54 2.03e-21 Lymphocyte counts; CESC cis rs763014 0.931 rs10903017 chr16:627920 T/C cg09263875 chr16:632152 PIGQ 0.67 11.07 0.56 1.14e-23 Height; CESC cis rs9303401 0.573 rs62081879 chr17:57181524 C/T cg25039879 chr17:56429692 SUPT4H1 0.5 5.13 0.3 5.66e-7 Cognitive test performance; CESC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg22535103 chr8:58192502 C8orf71 -0.94 -11.93 -0.59 1.55e-26 Developmental language disorder (linguistic errors); CESC cis rs3857536 0.813 rs9354404 chr6:66948408 C/T cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs644799 1.000 rs10831431 chr11:95510089 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.67 0.67 4.56e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs60871478 0.898 rs4725241 chr7:796883 C/T cg27478167 chr7:817139 HEATR2 -0.51 -6.03 -0.35 5.54e-9 Cerebrospinal P-tau181p levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18634782 chr6:136610989 BCLAF1 -0.49 -6.38 -0.36 7.97e-10 Fibrinogen levels; CESC cis rs9549367 0.662 rs3818334 chr13:113825174 C/G cg18105134 chr13:113819100 PROZ -0.68 -8.1 -0.45 2.04e-14 Platelet distribution width; CESC cis rs10883723 0.773 rs715439 chr10:104257809 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg26818010 chr10:134567672 INPP5A -0.9 -10.88 -0.56 4.78e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1018836 0.886 rs10112242 chr8:91642631 G/C cg16814680 chr8:91681699 NA -0.72 -11.03 -0.56 1.55e-23 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10424330 chr16:71894309 ZNF821;ATXN1L 0.49 6.22 0.36 1.94e-9 Fibrinogen levels; CESC cis rs6752107 1.000 rs6708373 chr2:234172846 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 6.71 0.38 1.19e-10 Crohn's disease;Inflammatory bowel disease; CESC trans rs10463316 0.894 rs12153347 chr5:150765471 C/T cg24389359 chr12:111284228 CCDC63 -0.34 -6.08 -0.35 4.19e-9 Metabolite levels (Pyroglutamine); CESC cis rs8044868 0.586 rs7190994 chr16:72099241 T/A cg16558253 chr16:72132732 DHX38 -0.41 -6.44 -0.37 5.61e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg23711669 chr6:146136114 FBXO30 -0.96 -14.87 -0.67 8.61e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs4819052 0.620 rs421619 chr21:46546115 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.54 5.76 0.33 2.34e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8141529 0.748 rs132531 chr22:29297365 C/T cg15103426 chr22:29168792 CCDC117 -0.61 -7.9 -0.44 7.26e-14 Lymphocyte counts; CESC cis rs1729951 0.546 rs12054219 chr3:136677472 G/A cg04103450 chr3:136751342 NA 0.39 5.2 0.3 4.01e-7 Neuroticism; CESC cis rs12681288 0.676 rs2600514 chr8:994175 G/A cg15309053 chr8:964076 NA 0.41 7.06 0.4 1.44e-11 Schizophrenia; CESC cis rs524023 1.000 rs524023 chr11:64358265 C/T cg07220939 chr11:64358617 SLC22A12 0.36 5.54 0.32 7.2e-8 Urate levels in obese individuals; CESC cis rs2952156 0.883 rs1495100 chr17:37832279 C/T cg20243544 chr17:37824526 PNMT 0.63 8.15 0.45 1.48e-14 Asthma; CESC cis rs6912958 0.559 rs242279 chr6:88048191 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.44 7.8 0.43 1.47e-13 Monocyte percentage of white cells; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03229959 chr8:38089560 DDHD2 0.47 6.19 0.36 2.22e-9 Systemic lupus erythematosus; CESC cis rs9403521 1.000 rs6901659 chr6:143985106 T/C cg21026257 chr6:143998961 PHACTR2 0.46 5.03 0.3 8.88e-7 Obesity-related traits; CESC cis rs977987 0.835 rs4888380 chr16:75347690 T/C cg03315344 chr16:75512273 CHST6 0.39 5.59 0.32 5.55e-8 Dupuytren's disease; CESC cis rs9487051 0.676 rs1608042 chr6:109595631 G/A cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg17971929 chr21:40555470 PSMG1 0.98 14.09 0.65 4.83e-34 Cognitive function; CESC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg22467129 chr15:76604101 ETFA -0.38 -5.8 -0.34 1.89e-8 Blood metabolite levels; CESC cis rs2074038 1.000 rs2074038 chr11:44087989 G/T cg17479956 chr11:44115929 EXT2 0.81 7.07 0.4 1.34e-11 IgA nephropathy; CESC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg11764359 chr7:65958608 NA 0.68 8.7 0.47 3.55e-16 Aortic root size; CESC cis rs17253792 0.822 rs10149408 chr14:56046075 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.95 0.34 8.68e-9 Putamen volume; CESC trans rs11088226 0.681 rs11700670 chr21:33938615 T/C cg09050820 chr6:167586206 TCP10L2 0.83 7.75 0.43 2.01e-13 Gastritis; CESC cis rs10927875 0.632 rs7535248 chr1:16129598 C/T cg18973939 chr1:16164122 FLJ37453 0.37 5.58 0.32 6.01e-8 Dilated cardiomyopathy; CESC cis rs1178968 0.901 rs799306 chr7:72801939 C/T cg25889504 chr7:72793014 NA 0.56 5.32 0.31 2.17e-7 Triglyceride levels; CESC cis rs4662945 0.504 rs35568023 chr2:130251812 A/T cg05962382 chr2:130345044 NA -0.46 -6.82 -0.39 6.19e-11 Response to cytidine analogues (gemcitabine); CESC cis rs4727963 0.777 rs4262262 chr7:122701364 A/G cg03640110 chr7:122635026 TAS2R16 -0.37 -5.7 -0.33 3.11e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs9486719 1.000 rs12208884 chr6:96885572 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg18230493 chr5:56204884 C5orf35 0.6 8.15 0.45 1.43e-14 Initial pursuit acceleration; CESC cis rs9322193 0.884 rs9688794 chr6:149953257 C/T cg07701084 chr6:150067640 NUP43 0.43 6.0 0.35 6.52e-9 Lung cancer; CESC trans rs6089829 1.000 rs6089828 chr20:61668998 C/T cg23505145 chr19:12996616 KLF1 0.54 6.97 0.39 2.49e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg11764359 chr7:65958608 NA 0.98 15.78 0.7 5.36e-40 Aortic root size; CESC cis rs7582720 1.000 rs6435169 chr2:203753016 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg01475377 chr6:109611718 NA -0.51 -8.56 -0.47 9.09e-16 Reticulocyte fraction of red cells; CESC cis rs9388451 0.839 rs980014 chr6:126068001 T/G cg10911889 chr6:126070802 HEY2 0.42 5.8 0.34 1.86e-8 Brugada syndrome; CESC cis rs4906332 1.000 rs12885234 chr14:103889181 A/G cg09975044 chr14:104007538 NA 0.46 6.38 0.36 7.81e-10 Coronary artery disease; CESC cis rs11809207 0.501 rs3762460 chr1:26495550 A/G cg00300879 chr1:26503847 CNKSR1 0.26 5.06 0.3 7.88e-7 Height; CESC cis rs7917772 0.503 rs7096072 chr10:104299976 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -5.97 -0.34 7.47e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1401999 1.000 rs2872249 chr3:183636273 T/A cg01324343 chr3:183735012 ABCC5 0.64 13.47 0.64 7.66e-32 Anterior chamber depth; CESC cis rs7772486 0.651 rs1292338 chr6:145967471 A/C cg23711669 chr6:146136114 FBXO30 -0.86 -12.69 -0.61 3.91e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.583 rs7222480 chr17:17818817 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.52 7.22 0.41 5.4e-12 Total body bone mineral density; CESC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg27121462 chr16:89883253 FANCA 0.75 11.1 0.56 9.55e-24 Vitiligo; CESC trans rs35110281 0.627 rs1836855 chr21:44965414 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 7.05 0.4 1.57e-11 Mean corpuscular volume; CESC cis rs881375 0.678 rs10760128 chr9:123696325 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 7.48 0.42 1.08e-12 Rheumatoid arthritis; CESC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg24562669 chr7:97807699 LMTK2 0.47 6.71 0.38 1.15e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs10129255 0.957 rs8009073 chr14:107185517 G/T cg23076370 chr14:107095027 NA -0.45 -5.59 -0.32 5.68e-8 Kawasaki disease; CESC cis rs611744 0.647 rs11785776 chr8:109264933 C/T cg21045802 chr8:109455806 TTC35 0.5 6.25 0.36 1.6e-9 Dupuytren's disease; CESC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg23758822 chr17:41437982 NA 1.03 17.57 0.73 2.4e-46 Menopause (age at onset); CESC cis rs56235845 0.694 rs11748912 chr5:176765395 G/A cg16006841 chr5:176797999 RGS14 0.46 5.71 0.33 2.96e-8 Hemoglobin concentration;Hematocrit; CESC cis rs4925166 1 rs4925166 chr17:18210810 T/G cg04261877 chr17:18218829 SMCR8;TOP3A 0.59 6.9 0.39 3.9e-11 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02045845 chr11:65338336 FAM89B;SSSCA1 0.58 6.84 0.39 5.46e-11 Gut microbiome composition (summer); CESC cis rs8038465 1.000 rs8041523 chr15:73982556 C/T cg15420318 chr15:73925796 NPTN 0.43 6.0 0.35 6.44e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs5769765 1.000 rs5769764 chr22:50270784 G/A cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs9733 0.744 rs2089081 chr1:150800117 T/C cg22823121 chr1:150693482 HORMAD1 -0.39 -5.93 -0.34 9.24e-9 Tonsillectomy; CESC cis rs6866344 0.697 rs62392832 chr5:178134395 T/C cg03877680 chr5:178157825 ZNF354A 0.68 7.84 0.43 1.09e-13 Neutrophil percentage of white cells; CESC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg14393609 chr7:65229607 NA 0.48 6.5 0.37 4e-10 Aortic root size; CESC cis rs6662572 0.737 rs7555458 chr1:46554142 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.17 0.3 4.73e-7 Blood protein levels; CESC trans rs2207136 0.835 rs571503 chr6:50904692 G/A cg06522515 chr3:184090630 THPO -0.36 -6.26 -0.36 1.56e-9 Myopia; CESC cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg05340658 chr4:99064831 C4orf37 0.84 13.04 0.63 2.35e-30 Colonoscopy-negative controls vs population controls; CESC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg04166393 chr7:2884313 GNA12 0.55 6.9 0.39 3.83e-11 Height; CESC cis rs208520 0.690 rs10455594 chr6:66737894 C/G cg07460842 chr6:66804631 NA 0.96 12.87 0.62 8.96e-30 Exhaled nitric oxide output; CESC cis rs10788972 0.903 rs7537946 chr1:54538700 A/G cg25741118 chr1:54482237 LDLRAD1 -0.22 -5.24 -0.31 3.35e-7 Parkinson disease and lewy body pathology; CESC cis rs7945705 0.935 rs11042102 chr11:8882164 C/T cg12365402 chr11:9010492 NRIP3 0.36 5.54 0.32 7.27e-8 Hemoglobin concentration; CESC cis rs10848704 1.000 rs10848704 chr12:2882544 A/G cg19995117 chr12:2880862 NA -0.54 -7.87 -0.44 9.09e-14 Quantitative traits; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03028685 chr10:99078963 FRAT1 -0.48 -6.22 -0.36 1.89e-9 Ulcerative colitis; CESC cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.61 0.47 6.66e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs7017914 0.967 rs7014012 chr8:71672743 G/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 4.01e-7 Bone mineral density; CESC cis rs12079745 0.793 rs3766064 chr1:169157919 A/G cg09363564 chr1:169337483 NME7;BLZF1 1.01 6.03 0.35 5.5e-9 QT interval; CESC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg11764359 chr7:65958608 NA -0.72 -9.54 -0.51 9.49e-19 Aortic root size; CESC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg24829409 chr8:58192753 C8orf71 -0.66 -7.28 -0.41 3.87e-12 Developmental language disorder (linguistic errors); CESC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg22862634 chr11:62369728 EML3;MTA2 0.48 6.38 0.36 7.82e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6493487 0.512 rs2306333 chr15:51217674 A/G cg02338191 chr15:51200825 AP4E1 0.6 5.57 0.32 6.13e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9300255 0.739 rs4759371 chr12:123742563 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.63 0.47 5.59e-16 Neutrophil percentage of white cells; CESC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg23708337 chr7:1209742 NA 0.49 5.31 0.31 2.35e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs67478160 0.643 rs12434686 chr14:104316033 C/T cg08213375 chr14:104286397 PPP1R13B -0.54 -10.51 -0.54 8.25e-22 Schizophrenia; CESC cis rs7103648 1.000 rs11039225 chr11:47430599 G/A cg20307385 chr11:47447363 PSMC3 0.97 16.84 0.72 9.04e-44 Diastolic blood pressure;Systolic blood pressure; CESC cis rs962856 0.619 rs1601530 chr2:67594916 G/A cg09028215 chr2:67624308 ETAA1 -0.44 -5.28 -0.31 2.66e-7 Pancreatic cancer; CESC cis rs11690935 0.632 rs2292816 chr2:172586714 G/C cg13550731 chr2:172543902 DYNC1I2 0.6 8.4 0.46 2.73e-15 Schizophrenia; CESC cis rs921968 0.612 rs832810 chr2:219322430 T/C cg02176678 chr2:219576539 TTLL4 0.38 6.67 0.38 1.48e-10 Mean corpuscular hemoglobin concentration; CESC cis rs1580019 0.961 rs6949851 chr7:32493807 T/G cg06627557 chr7:32535165 LSM5;AVL9 0.77 10.77 0.55 1.1e-22 Cognitive ability; CESC cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg17143192 chr8:8559678 CLDN23 0.77 8.79 0.48 1.94e-16 Obesity-related traits; CESC trans rs2727020 0.563 rs10769582 chr11:49474040 T/C cg15704280 chr7:45808275 SEPT13 -0.91 -15.68 -0.69 1.17e-39 Coronary artery disease; CESC cis rs1729951 0.575 rs1682356 chr3:136692037 T/C cg03617693 chr3:136751559 NA 0.39 5.48 0.32 9.84e-8 Neuroticism; CESC cis rs727505 0.607 rs67680878 chr7:124787381 G/A cg23710748 chr7:124431027 NA -0.4 -6.24 -0.36 1.73e-9 Lewy body disease; CESC cis rs473651 0.506 rs561264 chr2:239329979 G/T cg21699342 chr2:239360505 ASB1 0.43 5.63 0.33 4.67e-8 Multiple system atrophy; CESC cis rs1950626 0.827 rs35829821 chr14:101409763 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.79 10.67 0.55 2.42e-22 Pelvic organ prolapse (moderate/severe); CESC cis rs11264213 0.786 rs72659701 chr1:36317380 C/T cg27506609 chr1:36549197 TEKT2 0.66 5.51 0.32 8.52e-8 Schizophrenia; CESC cis rs929354 0.772 rs3802118 chr7:156986814 T/C cg05182265 chr7:156933206 UBE3C -0.51 -7.5 -0.42 9.58e-13 Body mass index; CESC cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg10523679 chr1:76189770 ACADM 0.65 6.11 0.35 3.62e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg11663144 chr21:46675770 NA -0.63 -9.75 -0.51 2.19e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4727027 0.704 rs12535154 chr7:148895304 G/A cg23583168 chr7:148888333 NA -0.95 -17.1 -0.72 1.08e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs854765 0.547 rs2955385 chr17:17939247 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.51 6.59 0.38 2.32e-10 Total body bone mineral density; CESC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg04166393 chr7:2884313 GNA12 0.62 8.46 0.46 1.85e-15 Height; CESC cis rs1048238 0.506 rs7552077 chr1:16196759 A/G cg22431228 chr1:16359049 CLCNKA -0.36 -6.53 -0.37 3.43e-10 Systolic blood pressure; CESC cis rs7264396 0.790 rs6060519 chr20:34217383 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.72 0.43 2.42e-13 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05668043 chr16:84733982 USP10 0.58 7.09 0.4 1.25e-11 Gut microbiome composition (summer); CESC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg13628971 chr7:2884303 GNA12 0.57 7.4 0.41 1.83e-12 Height; CESC cis rs7937682 0.889 rs1784786 chr11:111486043 A/G cg22437258 chr11:111473054 SIK2 -0.69 -9.02 -0.48 3.96e-17 Primary sclerosing cholangitis; CESC cis rs2479724 0.935 rs2025951 chr6:41827193 C/T cg17623882 chr6:41773611 USP49 0.4 5.88 0.34 1.2e-8 Menarche (age at onset); CESC cis rs7818688 0.697 rs11783985 chr8:95979886 A/G cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.22e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6087990 0.965 rs6058869 chr20:31348750 C/T cg13636640 chr20:31349939 DNMT3B 0.9 16.32 0.71 6.41e-42 Ulcerative colitis; CESC cis rs17376456 0.825 rs36042718 chr5:93180997 C/T cg25358565 chr5:93447407 FAM172A 1.11 10.79 0.55 9.8e-23 Diabetic retinopathy; CESC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg08470875 chr2:26401718 FAM59B 0.75 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs6001214 chr22:39149155 C/T cg21395723 chr22:39101663 GTPBP1 0.46 5.96 0.34 7.99e-9 Menopause (age at onset); CESC cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg03188948 chr7:1209495 NA 0.47 5.32 0.31 2.2e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs9393777 0.920 rs34150729 chr6:27388754 T/C cg06606381 chr12:133084897 FBRSL1 -1.12 -8.38 -0.46 3.2e-15 Intelligence (multi-trait analysis); CESC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg11764359 chr7:65958608 NA -0.74 -10.41 -0.54 1.72e-21 Aortic root size; CESC trans rs3741489 1.000 rs4758915 chr12:133477147 A/G cg24132527 chr5:140019269 TMCO6 1.05 7.12 0.4 1.01e-11 Cognitive function; CESC cis rs290268 0.874 rs290994 chr9:93559515 T/A cg02608019 chr9:93564028 SYK 0.67 10.21 0.53 7.53e-21 Platelet count; CESC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg10053473 chr17:62856997 LRRC37A3 -0.72 -7.56 -0.42 6.69e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01464969 chr4:1768943 NA 0.56 6.35 0.36 9.52e-10 Gut microbiome composition (summer); CESC cis rs62432291 0.681 rs2932988 chr6:159655402 A/G cg14500486 chr6:159655392 FNDC1 -0.62 -6.21 -0.36 2.04e-9 Joint mobility (Beighton score); CESC cis rs921968 0.643 rs559722 chr2:219398159 A/G cg02176678 chr2:219576539 TTLL4 0.42 7.44 0.42 1.43e-12 Mean corpuscular hemoglobin concentration; CESC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg09359103 chr1:154839909 KCNN3 -0.65 -12.4 -0.61 3.83e-28 Prostate cancer; CESC cis rs9611565 0.512 rs5758465 chr22:42175314 T/C cg06634786 chr22:41940651 POLR3H 0.67 6.62 0.38 1.93e-10 Vitiligo; CESC cis rs9303401 0.614 rs34678056 chr17:57177549 G/A cg12560992 chr17:57184187 TRIM37 0.5 5.21 0.3 3.78e-7 Cognitive test performance; CESC cis rs4481887 0.800 rs10888342 chr1:248441999 A/G cg00666640 chr1:248458726 OR2T12 0.33 5.71 0.33 3.05e-8 Common traits (Other); CESC cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg17366294 chr4:99064904 C4orf37 0.54 7.24 0.41 5.01e-12 Colonoscopy-negative controls vs population controls; CESC cis rs12824058 0.831 rs4759655 chr12:130815740 A/G cg24838063 chr12:130822603 PIWIL1 -0.64 -8.83 -0.48 1.51e-16 Menopause (age at onset); CESC cis rs7959452 0.535 rs7135092 chr12:69658330 T/C cg14784868 chr12:69753453 YEATS4 0.74 10.82 0.55 7.97e-23 Blood protein levels; CESC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg03352830 chr11:487213 PTDSS2 0.74 7.2 0.4 6.29e-12 Body mass index; CESC cis rs616402 0.527 rs2274985 chr1:10573867 G/A cg17425144 chr1:10567563 PEX14 0.38 6.12 0.35 3.27e-9 Breast size; CESC cis rs10751667 0.666 rs7105477 chr11:964271 C/G cg20946044 chr11:1010712 AP2A2 -0.4 -5.53 -0.32 7.72e-8 Alzheimer's disease (late onset); CESC cis rs344364 0.511 rs2982433 chr16:1954508 A/G cg03013636 chr16:1946785 NA 0.44 5.98 0.34 7.22e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs3091242 0.933 rs28530483 chr1:25740847 A/C cg27572855 chr1:25598939 RHD 0.44 7.17 0.4 7.61e-12 Erythrocyte sedimentation rate; CESC cis rs7762018 0.607 rs7759404 chr6:170135728 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.62 6.19 0.36 2.3e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs13034020 0.522 rs72809436 chr2:61251145 C/T cg18625361 chr2:61244694 PEX13;PUS10 0.66 5.9 0.34 1.13e-8 Hodgkin's lymphoma; CESC cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg20701182 chr2:24300061 SF3B14 0.93 10.38 0.54 2.17e-21 Lymphocyte counts; CESC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg15052019 chr19:19431593 KIAA0892;SF4 -0.42 -5.36 -0.31 1.77e-7 Tonsillectomy; CESC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.29 0.57 2.21e-24 Alzheimer's disease; CESC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.33 0.5 4.3e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs1577917 0.876 rs1582126 chr6:86697205 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.09 -0.35 3.92e-9 Response to antipsychotic treatment; CESC cis rs1499614 0.803 rs1922723 chr7:66175063 C/T cg12463550 chr7:65579703 CRCP 0.73 5.73 0.33 2.78e-8 Gout; CESC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg01238044 chr22:24384105 GSTT1 -0.47 -6.0 -0.35 6.35e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg25072359 chr17:41440525 NA 0.43 5.95 0.34 8.39e-9 Menopause (age at onset); CESC cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg18016565 chr1:150552671 MCL1 0.34 5.23 0.31 3.36e-7 Tonsillectomy; CESC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.68 -7.76 -0.43 1.83e-13 Gut microbiome composition (summer); CESC cis rs4746818 0.901 rs10740317 chr10:70937566 G/A cg04149295 chr10:70884716 VPS26A 0.58 5.08 0.3 7.06e-7 Left atrial antero-posterior diameter; CESC cis rs10883723 0.773 rs2296587 chr10:104245588 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.57 6.95 0.39 2.86e-11 Allergic disease (asthma, hay fever or eczema); CESC cis rs9486719 0.843 rs2499797 chr6:96848669 C/T cg18709589 chr6:96969512 KIAA0776 0.55 5.4 0.31 1.47e-7 Migraine;Coronary artery disease; CESC cis rs708547 0.874 rs1713984 chr4:57886493 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.69 7.7 0.43 2.7e-13 Response to bleomycin (chromatid breaks); CESC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg26939375 chr7:64535504 NA 0.76 10.85 0.55 6e-23 Aortic root size; CESC cis rs9814567 1.000 rs9289471 chr3:134230811 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.46 -6.24 -0.36 1.69e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs61931739 0.534 rs12831685 chr12:34038392 C/T cg26384229 chr12:38710491 ALG10B 0.5 6.74 0.38 9.74e-11 Morning vs. evening chronotype; CESC cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg09658497 chr7:2847517 GNA12 -0.35 -5.27 -0.31 2.85e-7 Height; CESC cis rs9487051 0.621 rs396635 chr6:109523508 A/G cg01475377 chr6:109611718 NA -0.39 -5.15 -0.3 5.18e-7 Reticulocyte fraction of red cells; CESC cis rs28374715 0.681 rs7163989 chr15:41614621 A/G cg02330683 chr15:41787940 ITPKA 0.47 6.26 0.36 1.58e-9 Ulcerative colitis; CESC cis rs9309473 1.000 rs56154726 chr2:73721767 C/T cg20560298 chr2:73613845 ALMS1 -0.55 -7.15 -0.4 8.23e-12 Metabolite levels; CESC trans rs9929218 1.000 rs8045022 chr16:68807087 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -8.03 -0.44 3.1e-14 Colorectal cancer; CESC cis rs12541635 0.677 rs6469026 chr8:107006356 T/C cg10147462 chr8:107024639 NA 0.43 6.37 0.36 8.26e-10 Age of smoking initiation; CESC cis rs1348850 0.537 rs3770010 chr2:178537796 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.24 0.41 4.92e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg05347473 chr6:146136440 FBXO30 -0.55 -6.66 -0.38 1.6e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg12463550 chr7:65579703 CRCP 0.49 6.35 0.36 9.51e-10 Aortic root size; CESC cis rs1620921 0.505 rs12526591 chr6:161204311 T/A cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27209265 chr16:790912 NARFL 0.56 6.79 0.38 7.37e-11 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg08888203 chr3:10149979 C3orf24 0.47 6.21 0.36 2.03e-9 Alzheimer's disease; CESC cis rs4481887 0.893 rs6702113 chr1:248486151 T/C cg00666640 chr1:248458726 OR2T12 0.35 5.98 0.35 7.04e-9 Common traits (Other); CESC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.26 0.36 1.51e-9 Cystic fibrosis severity; CESC cis rs4969178 0.965 rs938350 chr17:76399552 C/T cg05887092 chr17:76393375 PGS1 0.58 9.19 0.49 1.15e-17 HDL cholesterol levels; CESC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg11644478 chr21:40555479 PSMG1 -0.55 -7.6 -0.42 5.07e-13 Menarche (age at onset); CESC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg19680485 chr15:31195859 MTMR15 0.48 5.86 0.34 1.35e-8 Huntington's disease progression; CESC cis rs2011503 1.000 rs2916072 chr19:19525712 G/A cg11584989 chr19:19387371 SF4 0.65 7.59 0.42 5.44e-13 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27365485 chr11:64126452 RPS6KA4 -0.39 -6.29 -0.36 1.3e-9 Gambling; CESC trans rs11098499 0.955 rs11931312 chr4:120159023 T/C cg25214090 chr10:38739885 LOC399744 0.64 8.6 0.47 7.03e-16 Corneal astigmatism; CESC cis rs477692 0.905 rs485579 chr10:131425492 T/G cg05714579 chr10:131428358 MGMT 0.58 8.4 0.46 2.67e-15 Response to temozolomide; CESC cis rs72627123 0.867 rs73303113 chr14:74481068 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.79 5.81 0.34 1.8e-8 Morning vs. evening chronotype; CESC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg06634786 chr22:41940651 POLR3H -0.69 -7.12 -0.4 1.01e-11 Vitiligo; CESC cis rs3105593 0.555 rs3131560 chr15:50775562 T/C cg08437265 chr15:50716283 USP8 0.48 6.32 0.36 1.09e-9 QT interval; CESC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.71 0.38 1.14e-10 Bipolar disorder; CESC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg11494091 chr17:61959527 GH2 0.72 12.22 0.6 1.56e-27 Prudent dietary pattern; CESC cis rs7808935 0.628 rs12666442 chr7:27937203 C/T cg05786569 chr7:27702416 HIBADH 0.53 5.87 0.34 1.28e-8 Prostate cancer; CESC cis rs8077577 0.945 rs34474249 chr17:18074525 T/C cg16794390 chr17:18148240 FLII 0.42 5.64 0.33 4.41e-8 Obesity-related traits; CESC cis rs722599 0.715 rs2080086 chr14:75338408 G/A cg08847533 chr14:75593920 NEK9 -0.45 -5.71 -0.33 3.01e-8 IgG glycosylation; CESC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg19626725 chr5:178986131 RUFY1 0.33 5.1 0.3 6.5e-7 Lung cancer; CESC cis rs933688 1.000 rs889213 chr5:90682151 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 12.36 0.6 5.17e-28 Smoking behavior; CESC cis rs208346 0.612 rs208356 chr7:2775825 A/T cg19717773 chr7:2847554 GNA12 0.68 11.21 0.57 3.86e-24 Loneliness (linear analysis); CESC cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg18404041 chr3:52824283 ITIH1 -0.39 -5.62 -0.33 4.89e-8 Bipolar disorder; CESC cis rs796364 0.951 rs769952 chr2:200734368 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 8.19 0.45 1.12e-14 Schizophrenia; CESC cis rs4481887 1.000 rs4244182 chr1:248471174 A/G cg00666640 chr1:248458726 OR2T12 0.4 6.57 0.37 2.7e-10 Common traits (Other); CESC cis rs10992471 0.756 rs7043152 chr9:95138499 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -5.68 -0.33 3.52e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg22029157 chr1:209979665 IRF6 0.6 8.91 0.48 8.14e-17 Cleft lip with or without cleft palate; CESC cis rs9300255 0.602 rs1616131 chr12:123619838 G/A cg05973401 chr12:123451056 ABCB9 0.53 5.92 0.34 9.71e-9 Neutrophil percentage of white cells; CESC cis rs55788414 0.932 rs8059559 chr16:81185684 G/A cg06400318 chr16:81190750 PKD1L2 0.59 6.83 0.39 5.74e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs4704187 0.687 rs6860441 chr5:74389799 G/A cg03227963 chr5:74354835 NA 0.32 5.92 0.34 9.97e-9 Response to amphetamines; CESC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg23978390 chr7:1156363 C7orf50 0.45 6.04 0.35 5.3e-9 Longevity;Endometriosis; CESC cis rs6088580 0.634 rs6120650 chr20:33039973 G/A cg24642439 chr20:33292090 TP53INP2 0.52 6.82 0.39 6.28e-11 Glomerular filtration rate (creatinine); CESC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg25072359 chr17:41440525 NA 0.48 6.52 0.37 3.45e-10 Menopause (age at onset); CESC cis rs7927592 0.763 rs1193699 chr11:68249480 C/G cg16797656 chr11:68205561 LRP5 0.48 7.43 0.42 1.48e-12 Total body bone mineral density; CESC cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.65 7.45 0.42 1.31e-12 Age-related macular degeneration (geographic atrophy); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09251995 chr19:18392994 JUND -0.48 -6.31 -0.36 1.18e-9 Asthma; CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg22907277 chr7:1156413 C7orf50 0.42 5.91 0.34 1.05e-8 Longevity;Endometriosis; CESC cis rs4409675 0.576 rs7356 chr1:28218100 T/C cg23691781 chr1:28212827 C1orf38 0.3 5.92 0.34 1.02e-8 Corneal astigmatism; CESC cis rs12136530 0.554 rs4912093 chr1:19762321 T/C cg01832549 chr1:19774989 CAPZB -0.47 -6.48 -0.37 4.5e-10 Lead levels in blood; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23031969 chr7:5014415 RNF216L -0.46 -6.94 -0.39 2.93e-11 Fibrinogen levels; CESC cis rs10949834 0.504 rs150862 chr7:73524207 C/T cg07137043 chr7:73588983 EIF4H 0.64 7.58 0.42 5.84e-13 Verbal memory performance (residualized delayed recall change); CESC cis rs4660261 0.526 rs810680 chr1:44347856 C/T cg13606994 chr1:44402422 ARTN -0.38 -5.78 -0.33 2.14e-8 Intelligence (multi-trait analysis); CESC cis rs9488822 0.676 rs13194714 chr6:116394819 T/A cg15226275 chr6:116381976 FRK 0.25 6.32 0.36 1.08e-9 Cholesterol, total;LDL cholesterol; CESC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg10691866 chr7:65817282 TPST1 0.33 5.47 0.32 1.02e-7 Aortic root size; CESC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg18337363 chr3:52569053 NT5DC2 -0.31 -5.17 -0.3 4.69e-7 Bipolar disorder; CESC cis rs3105593 0.635 rs3131567 chr15:50757930 A/T cg08437265 chr15:50716283 USP8 0.46 6.17 0.35 2.48e-9 QT interval; CESC cis rs7249142 0.549 rs12975253 chr19:19279745 A/C cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.29 5.22 0.31 3.57e-7 IgG glycosylation; CESC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg18876405 chr7:65276391 NA 0.51 6.94 0.39 3e-11 Aortic root size; CESC cis rs2985684 0.948 rs11623263 chr14:50083295 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.47 -5.6 -0.33 5.45e-8 Carotid intima media thickness; CESC cis rs748404 0.560 rs570933 chr15:43824030 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.49 7.55 0.42 7.09e-13 Lung cancer; CESC cis rs3768617 0.565 rs7542277 chr1:183063527 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.13 0.63 1.16e-30 Fuchs's corneal dystrophy; CESC cis rs7395581 0.918 rs12575456 chr11:47326073 G/A cg25783544 chr11:47291846 MADD 0.61 7.92 0.44 6.78e-14 HDL cholesterol; CESC cis rs9660992 0.674 rs56198325 chr1:205265450 G/A cg21643547 chr1:205240462 TMCC2 -0.49 -6.52 -0.37 3.5e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg26335602 chr6:28129616 ZNF389 0.53 6.74 0.38 9.91e-11 Depression; CESC cis rs10911232 0.507 rs4652772 chr1:183023696 C/G ch.1.3577855R chr1:183094577 LAMC1 -0.84 -12.89 -0.62 7.57e-30 Hypertriglyceridemia; CESC trans rs1814175 0.616 rs1794139 chr11:49910855 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -6.3 -0.36 1.26e-9 Height; CESC cis rs10489525 1.000 rs10489525 chr1:115263685 A/G cg01522456 chr1:115632236 TSPAN2 -0.45 -5.36 -0.31 1.82e-7 Autism; CESC trans rs877282 0.842 rs12357963 chr10:757562 C/T cg22713356 chr15:30763199 NA 1.05 9.16 0.49 1.45e-17 Uric acid levels; CESC cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg05340658 chr4:99064831 C4orf37 0.78 11.83 0.59 3.34e-26 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.573 rs73267873 chr17:29068457 C/T cg13385521 chr17:29058706 SUZ12P 0.74 6.21 0.36 2.01e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7178909 0.872 rs57715404 chr15:90433958 T/C cg19708238 chr15:90437601 AP3S2 0.42 5.83 0.34 1.57e-8 Common traits (Other); CESC cis rs2880765 0.835 rs4842884 chr15:86035174 T/C cg10818794 chr15:86012489 AKAP13 -0.35 -5.42 -0.32 1.34e-7 Coronary artery disease; CESC cis rs11098499 0.954 rs11098524 chr4:120390032 A/G cg24375607 chr4:120327624 NA 0.49 5.88 0.34 1.24e-8 Corneal astigmatism; CESC cis rs854765 0.547 rs6502633 chr17:17941037 G/C cg16928487 chr17:17741425 SREBF1 -0.54 -8.97 -0.48 5.44e-17 Total body bone mineral density; CESC cis rs34779708 0.733 rs4298846 chr10:35547380 A/G cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs7772486 0.875 rs2814875 chr6:146305810 G/A cg05347473 chr6:146136440 FBXO30 0.56 7.37 0.41 2.14e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs3820928 0.869 rs2396436 chr2:227795464 G/A cg05526886 chr2:227700861 RHBDD1 -0.4 -5.1 -0.3 6.58e-7 Pulmonary function; CESC cis rs2629540 0.924 rs1545910 chr10:126428145 G/C cg08799069 chr10:126477246 METTL10 -0.68 -9.05 -0.49 3.16e-17 Cocaine dependence; CESC cis rs5750830 0.594 rs5757647 chr22:39775047 C/A cg24399712 chr22:39784796 NA -0.77 -11.05 -0.56 1.34e-23 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10514093 chr5:156277587 PPP1R2P3 -0.56 -6.91 -0.39 3.7e-11 Gut microbiome composition (summer); CESC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg02592271 chr2:27665507 KRTCAP3 -0.3 -6.02 -0.35 5.73e-9 Total body bone mineral density; CESC cis rs11676348 0.783 rs4674252 chr2:218984478 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.03 -0.35 5.51e-9 Ulcerative colitis; CESC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs739401 0.611 rs417957 chr11:3046231 A/G cg08508325 chr11:3079039 CARS -0.53 -10.56 -0.54 5.43e-22 Longevity; CESC cis rs7274811 0.744 rs3213183 chr20:32262962 C/T cg21523528 chr20:32077966 CBFA2T2 0.56 6.51 0.37 3.8e-10 Height; CESC cis rs6663390 0.831 rs3754172 chr1:208086878 G/T cg00387621 chr1:208086895 NA 0.41 5.04 0.3 8.57e-7 Facial morphology (factor 18); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07513383 chr19:52552126 ZNF432 -0.46 -6.03 -0.35 5.45e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.76 0.38 8.98e-11 Bipolar disorder; CESC cis rs60843830 1.000 rs17713396 chr2:227201 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.88 11.44 0.57 6.88e-25 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs832540 0.931 rs832536 chr5:56212595 C/T cg12311346 chr5:56204834 C5orf35 -0.42 -5.21 -0.3 3.88e-7 Coronary artery disease; CESC cis rs2901656 1.000 rs6699095 chr1:172429245 T/C cg03748243 chr1:172413542 C1orf105;PIGC 0.4 6.19 0.36 2.33e-9 Red cell distribution width;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16681977 chr1:11332969 UBIAD1 0.55 6.21 0.36 1.98e-9 Gut microbiome composition (summer); CESC cis rs10883723 0.668 rs12414407 chr10:104387019 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.54 -7.5 -0.42 9.48e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs684232 0.666 rs838371 chr17:609275 T/C cg12384639 chr17:618140 VPS53 0.4 5.19 0.3 4.22e-7 Prostate cancer; CESC cis rs72781680 1.000 rs11125372 chr2:24257582 A/T cg08917208 chr2:24149416 ATAD2B -0.8 -7.51 -0.42 8.95e-13 Lymphocyte counts; CESC cis rs9291683 0.588 rs13133766 chr4:10019732 C/T cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.73e-37 Bone mineral density; CESC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg26850624 chr5:429559 AHRR -0.5 -6.76 -0.38 8.87e-11 Cystic fibrosis severity; CESC cis rs9462846 0.959 rs9471960 chr6:42884750 A/C cg05552183 chr6:42928497 GNMT 0.44 5.24 0.31 3.22e-7 Blood protein levels; CESC cis rs116095464 0.558 rs6878087 chr5:223117 C/T cg22496380 chr5:211416 CCDC127 0.66 7.87 0.44 9.06e-14 Breast cancer; CESC cis rs9811920 0.770 rs4928237 chr3:99731330 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -5.04 -0.3 8.68e-7 Axial length; CESC cis rs9300255 0.679 rs10846507 chr12:123786492 G/T cg00376283 chr12:123451042 ABCB9 0.58 6.88 0.39 4.38e-11 Neutrophil percentage of white cells; CESC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg13628971 chr7:2884303 GNA12 0.63 8.01 0.44 3.58e-14 Height; CESC cis rs7084402 0.967 rs1658494 chr10:60280323 C/T cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC cis rs1348850 0.626 rs1901825 chr2:178225331 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.76 10.83 0.55 7.38e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2991971 0.810 rs998199 chr1:45912898 A/C cg15605315 chr1:45957053 TESK2 -0.39 -5.31 -0.31 2.27e-7 High light scatter reticulocyte count; CESC cis rs7258465 1.000 rs28572537 chr19:18552208 C/T cg25828334 chr19:18545568 ISYNA1 -0.32 -5.15 -0.3 5.19e-7 Breast cancer; CESC cis rs8014204 1.000 rs10483863 chr14:75322327 A/G cg08847533 chr14:75593920 NEK9 -0.43 -5.64 -0.33 4.38e-8 Caffeine consumption; CESC cis rs9612 0.718 rs346522 chr19:44262545 C/T cg08581076 chr19:44259116 C19orf61 -0.47 -5.87 -0.34 1.33e-8 Exhaled nitric oxide output; CESC cis rs12477438 0.798 rs2045057 chr2:99684929 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs7259376 0.936 rs59598661 chr19:22537029 T/A cg02657401 chr19:22469223 NA -0.26 -5.19 -0.3 4.17e-7 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04607442 chr13:21872219 NA 0.64 6.93 0.39 3.14e-11 Gut microbiome composition (summer); CESC cis rs4835473 0.900 rs13137885 chr4:144655365 T/C cg25736465 chr4:144833511 NA -0.32 -5.04 -0.3 8.48e-7 Immature fraction of reticulocytes; CESC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg18876405 chr7:65276391 NA 0.52 6.87 0.39 4.49e-11 Aortic root size; CESC cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg20503657 chr10:835505 NA 0.75 7.7 0.43 2.63e-13 Eosinophil percentage of granulocytes; CESC cis rs7945705 0.935 rs11042102 chr11:8882164 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.48 7.56 0.42 6.46e-13 Hemoglobin concentration; CESC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.44 7.45 0.42 1.29e-12 Personality dimensions; CESC cis rs992157 0.661 rs10171839 chr2:219051314 C/T cg00012203 chr2:219082015 ARPC2 0.75 10.91 0.56 4.02e-23 Colorectal cancer; CESC cis rs9467711 0.606 rs72836482 chr6:26359241 A/T cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.52e-7 Autism spectrum disorder or schizophrenia; CESC cis rs4450798 0.793 rs62234798 chr3:13753974 T/C cg23332027 chr3:13681764 NA 0.41 5.46 0.32 1.11e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg17724175 chr1:150552817 MCL1 0.43 6.53 0.37 3.35e-10 Melanoma; CESC cis rs6963495 0.818 rs6943132 chr7:105166776 C/T cg19920283 chr7:105172520 RINT1 0.72 5.52 0.32 8.03e-8 Bipolar disorder (body mass index interaction); CESC cis rs11920090 0.789 rs11711206 chr3:170732945 A/G cg09710316 chr3:170744871 SLC2A2 0.51 5.77 0.33 2.25e-8 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs9926296 0.546 rs9935541 chr16:89905925 G/C cg27121462 chr16:89883253 FANCA 0.57 6.76 0.38 8.51e-11 Vitiligo; CESC cis rs9640161 0.789 rs11767409 chr7:150058043 C/T cg17279839 chr7:150038598 RARRES2 0.46 5.51 0.32 8.38e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs2074585 0.713 rs2589941 chr15:90931457 C/T cg10434728 chr15:90938212 IQGAP1 0.42 7.69 0.43 2.9e-13 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg11764359 chr7:65958608 NA -0.89 -13.68 -0.64 1.31e-32 Aortic root size; CESC cis rs67478160 0.634 rs7141928 chr14:104219949 C/T cg08213375 chr14:104286397 PPP1R13B 0.47 9.32 0.5 4.86e-18 Schizophrenia; CESC cis rs9287719 0.967 rs759402 chr2:10729554 A/T cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.35e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11409060 chr12:14518540 ATF7IP -0.57 -6.83 -0.39 5.89e-11 Gut microbiome composition (summer); CESC trans rs8073060 0.544 rs225252 chr17:33952401 G/A cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg05025164 chr4:1340916 KIAA1530 -0.67 -9.17 -0.49 1.41e-17 Obesity-related traits; CESC cis rs4718428 0.662 rs34577323 chr7:66310041 G/C cg12165864 chr7:66369176 NA -0.65 -7.39 -0.41 1.88e-12 Corneal structure; CESC cis rs35110281 0.622 rs9977258 chr21:44976485 G/T cg01579765 chr21:45077557 HSF2BP -0.51 -8.21 -0.45 9.73e-15 Mean corpuscular volume; CESC cis rs644799 0.931 rs496305 chr11:95567035 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 13.72 0.64 9.86e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7091068 0.754 rs6583903 chr10:95422174 T/C cg20715218 chr10:95462985 C10orf4 0.59 6.16 0.35 2.73e-9 Urinary tract infection frequency; CESC cis rs1950626 0.750 rs34228453 chr14:101440321 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.83 11.29 0.57 2.14e-24 Pelvic organ prolapse (moderate/severe); CESC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg16743903 chr16:89593216 SPG7 -0.43 -5.59 -0.32 5.7e-8 Multiple myeloma (IgH translocation); CESC cis rs3741151 1.000 rs78433080 chr11:73067565 G/A cg17517138 chr11:73019481 ARHGEF17 1.02 6.93 0.39 3.11e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.4 0.61 3.79e-28 Alzheimer's disease; CESC cis rs9486719 0.843 rs1009597 chr6:96843540 A/T cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC cis rs1957429 0.901 rs2884308 chr14:65350406 A/T cg23373153 chr14:65346875 NA -0.93 -10.8 -0.55 8.96e-23 Pediatric areal bone mineral density (radius); CESC cis rs4851870 1.000 rs4851871 chr2:106439218 A/G cg16077055 chr2:106428750 NCK2 -0.4 -5.14 -0.3 5.23e-7 Addiction; CESC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs963731 0.649 rs10186762 chr2:39219361 A/G cg04010122 chr2:39346883 SOS1 -0.76 -5.58 -0.32 5.98e-8 Corticobasal degeneration; CESC cis rs965513 1.000 rs7020976 chr9:100547972 T/C cg13688889 chr9:100608707 NA -0.6 -8.62 -0.47 6.27e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.2 0.3 3.96e-7 Menopause (age at onset); CESC cis rs17376456 0.825 rs12188163 chr5:93250608 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 -0.65 -5.5 -0.32 8.97e-8 Diabetic retinopathy; CESC cis rs4727027 0.933 rs6961605 chr7:148870108 G/A cg23158103 chr7:148848205 ZNF398 -0.41 -6.61 -0.38 2.09e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3820068 0.580 rs12082523 chr1:16005792 A/G cg13390004 chr1:15929781 NA -0.33 -5.25 -0.31 3.19e-7 Systolic blood pressure; CESC cis rs367615 0.552 rs2115511 chr5:108725403 A/T cg17395555 chr5:108820864 NA -0.44 -7.4 -0.41 1.8e-12 Colorectal cancer (SNP x SNP interaction); CESC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg22920501 chr2:26401640 FAM59B 0.91 10.33 0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23071962 chr2:12856964 TRIB2 0.63 7.62 0.42 4.56e-13 Gut microbiome composition (summer); CESC cis rs3105593 1.000 rs12439744 chr15:50899211 C/T cg08437265 chr15:50716283 USP8 0.41 5.37 0.31 1.76e-7 QT interval; CESC cis rs2243480 1.000 rs6970243 chr7:65388490 C/A cg13147721 chr7:65941812 NA -0.85 -8.1 -0.45 2e-14 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16116313 chr12:122255002 SETD1B -0.63 -7.22 -0.41 5.4e-12 Gut microbiome composition (summer); CESC cis rs7089973 0.604 rs10885618 chr10:116617718 A/G cg25233709 chr10:116636983 FAM160B1 0.4 6.61 0.38 2.08e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg22903657 chr4:1355424 KIAA1530 -0.38 -5.11 -0.3 6.12e-7 Obesity-related traits; CESC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC trans rs1814175 0.645 rs1818895 chr11:50031523 G/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.5 -0.75 1.25e-49 Height; CESC cis rs644799 0.710 rs1852535 chr11:95501241 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.78 11.71 0.58 8.64e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4803468 1.000 rs2569754 chr19:41936734 A/G cg08639244 chr19:41945921 ATP5SL -0.43 -5.32 -0.31 2.24e-7 Height; CESC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.64 -8.23 -0.45 8.51e-15 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13751645 chr22:17513505 NA -0.47 -6.22 -0.36 1.89e-9 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg10691866 chr7:65817282 TPST1 -0.34 -5.67 -0.33 3.76e-8 Aortic root size; CESC cis rs362272 0.545 rs2749782 chr4:3339761 A/G cg08886695 chr4:3369023 RGS12 -0.4 -5.43 -0.32 1.29e-7 Serum sulfate level; CESC cis rs12497850 0.931 rs4974082 chr3:48999323 G/A cg06212747 chr3:49208901 KLHDC8B 0.73 10.02 0.52 3.02e-20 Parkinson's disease; CESC cis rs7582720 1.000 rs72926781 chr2:203808835 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs8141529 0.956 rs132539 chr22:29304253 C/T cg02153584 chr22:29168773 CCDC117 0.45 5.38 0.31 1.65e-7 Lymphocyte counts; CESC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg20896738 chr21:46707857 POFUT2;LOC642852 -0.44 -5.61 -0.33 5.1e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs17001868 0.527 rs73167009 chr22:40734249 T/C cg07138101 chr22:40742427 ADSL 0.54 5.18 0.3 4.49e-7 Mammographic density (dense area); CESC cis rs1620921 0.505 rs34797199 chr6:161203769 C/T cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg11764359 chr7:65958608 NA 0.67 8.85 0.48 1.28e-16 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20118422 chr15:64455210 PPIB 0.63 7.5 0.42 9.57e-13 Gut microbiome composition (summer); CESC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg06877462 chr1:205807181 PM20D1 0.37 5.41 0.32 1.41e-7 Menarche (age at onset); CESC cis rs2637266 0.703 rs2395435 chr10:78476163 G/C cg18941641 chr10:78392320 NA 0.39 7.38 0.41 2.05e-12 Pulmonary function; CESC cis rs8180040 0.726 rs6785790 chr3:47146932 C/T cg27129171 chr3:47204927 SETD2 0.7 10.5 0.54 8.74e-22 Colorectal cancer; CESC cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg02297831 chr4:17616191 MED28 0.44 5.4 0.31 1.46e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7264396 0.790 rs6060526 chr20:34225302 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.84 10.38 0.54 2.06e-21 Total cholesterol levels; CESC cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg14416269 chr4:6271139 WFS1 0.47 8.04 0.44 3.08e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg27266027 chr21:40555129 PSMG1 0.4 5.12 0.3 5.9e-7 Cognitive function; CESC cis rs317689 0.513 rs317659 chr12:69686132 T/A cg14784868 chr12:69753453 YEATS4 0.53 6.55 0.37 2.96e-10 Response to diuretic therapy; CESC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg24829409 chr8:58192753 C8orf71 -0.66 -7.93 -0.44 6.14e-14 Developmental language disorder (linguistic errors); CESC cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg05347473 chr6:146136440 FBXO30 0.57 7.24 0.41 4.72e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2070488 0.689 rs6809352 chr3:38544349 G/A cg24069376 chr3:38537580 EXOG -0.33 -5.75 -0.33 2.45e-8 Electrocardiographic conduction measures; CESC cis rs1707322 1.000 rs12097761 chr1:46291162 T/C cg06784218 chr1:46089804 CCDC17 0.34 5.77 0.33 2.17e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3820928 1.000 rs10204368 chr2:227774244 G/C cg05526886 chr2:227700861 RHBDD1 -0.42 -5.54 -0.32 7.19e-8 Pulmonary function; CESC cis rs2506889 0.553 rs11580264 chr1:10605796 C/A cg17425144 chr1:10567563 PEX14 0.34 5.27 0.31 2.79e-7 Breast cancer; CESC cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.6e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs12464559 0.522 rs4300824 chr2:152581866 T/C cg01189475 chr2:152685088 ARL5A 0.65 6.14 0.35 3.04e-9 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs67478160 0.619 rs10083370 chr14:104314182 G/A cg01849466 chr14:104193079 ZFYVE21 0.5 6.84 0.39 5.43e-11 Schizophrenia; CESC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.2 -0.36 2.21e-9 Parkinson's disease; CESC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.91 13.75 0.65 7.71e-33 Prudent dietary pattern; CESC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg08704250 chr15:31115839 NA 0.69 9.23 0.49 8.87e-18 Huntington's disease progression; CESC cis rs9467711 0.538 rs35942482 chr6:26444938 T/A cg12826209 chr6:26865740 GUSBL1 0.67 5.15 0.3 5.15e-7 Autism spectrum disorder or schizophrenia; CESC cis rs6952809 0.590 rs1468337 chr7:2432211 C/T cg23289794 chr7:2394357 EIF3B -0.72 -6.86 -0.39 4.82e-11 Multiple sclerosis; CESC trans rs7922314 0.571 rs16917985 chr10:64732314 T/C cg06935979 chr1:232941706 KIAA1383 -0.66 -6.0 -0.35 6.47e-9 Cutaneous psoriasis; CESC cis rs854765 0.575 rs7207821 chr17:17891781 A/G cg04398451 chr17:18023971 MYO15A -0.71 -10.17 -0.53 1.03e-20 Total body bone mineral density; CESC cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.67 0.47 4.29e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2070488 0.636 rs2284817 chr3:38510388 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.68 8.88 0.48 1.01e-16 Electrocardiographic conduction measures; CESC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.99e-8 Eye color traits; CESC cis rs9300255 0.602 rs2510885 chr12:123614813 G/C cg19016782 chr12:123741754 C12orf65 -0.4 -5.62 -0.33 4.74e-8 Neutrophil percentage of white cells; CESC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 10.48 0.54 9.64e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7188697 0.922 rs7199856 chr16:58584772 A/C cg02549819 chr16:58548995 SETD6 -0.42 -5.42 -0.32 1.36e-7 QT interval; CESC cis rs4132509 1.000 rs9287269 chr1:243954551 G/A cg21452805 chr1:244014465 NA 0.45 5.67 0.33 3.65e-8 RR interval (heart rate); CESC cis rs6582630 0.555 rs11181053 chr12:38271364 T/C cg26384229 chr12:38710491 ALG10B -0.45 -5.97 -0.34 7.79e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs6429082 0.791 rs291394 chr1:235651682 A/G cg26050004 chr1:235667680 B3GALNT2 0.63 7.82 0.43 1.24e-13 Adiposity; CESC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg06219351 chr7:158114137 PTPRN2 -0.5 -7.84 -0.43 1.1e-13 Calcium levels; CESC cis rs12900413 0.687 rs35562959 chr15:90310537 C/T cg24249390 chr15:90295951 MESP1 -0.4 -5.5 -0.32 9.05e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs12134245 0.747 rs11164929 chr1:92012836 G/C cg07090678 chr1:91966139 CDC7 0.38 5.37 0.31 1.74e-7 Breast cancer; CESC cis rs13242816 1.000 rs55803834 chr7:116103141 C/T cg04696780 chr7:116139425 CAV2 -0.62 -5.69 -0.33 3.31e-8 P wave duration; CESC cis rs1348850 0.526 rs10803912 chr2:178407176 A/C cg02961200 chr2:178257176 LOC100130691;AGPS -0.64 -5.94 -0.34 8.78e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1881797 0.872 rs2141544 chr1:247690800 A/G cg21399703 chr1:247681439 NA 0.5 7.59 0.42 5.3e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs7617773 0.539 rs12486935 chr3:48390164 C/T cg11946769 chr3:48343235 NME6 0.66 8.41 0.46 2.55e-15 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05712126 chr22:29601860 EMID1 -0.47 -6.12 -0.35 3.44e-9 Fibrinogen levels; CESC cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1048238 0.846 rs945422 chr1:16345619 T/C cg22431228 chr1:16359049 CLCNKA -0.55 -11.23 -0.57 3.4e-24 Systolic blood pressure; CESC cis rs6032067 1.000 rs13038434 chr20:43888106 G/A cg11264863 chr20:43835661 SEMG1 0.48 5.05 0.3 8.23e-7 Blood protein levels; CESC cis rs10789491 0.953 rs1866770 chr1:47182468 G/T cg15501359 chr1:47185051 KIAA0494 0.8 8.75 0.47 2.51e-16 Response to hepatitis C treatment; CESC cis rs9486719 1.000 rs2273622 chr6:97058567 A/G cg06623918 chr6:96969491 KIAA0776 -0.82 -8.57 -0.47 8.91e-16 Migraine;Coronary artery disease; CESC cis rs4629710 0.592 rs13195700 chr6:131585299 C/T cg12606694 chr6:131520996 AKAP7 0.46 5.74 0.33 2.56e-8 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26052635 chr2:29339307 CLIP4 -0.53 -6.52 -0.37 3.64e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24376286 chr2:198245629 NA -0.6 -6.82 -0.39 6.17e-11 Gut microbiome composition (summer); CESC cis rs6076065 0.925 rs6083106 chr20:23368809 A/C cg11657817 chr20:23433608 CST11 0.36 5.35 0.31 1.92e-7 Facial morphology (factor 15, philtrum width); CESC cis rs2273669 0.667 rs11755471 chr6:109342169 T/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs9457247 1.000 rs389946 chr6:167407268 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.89 0.34 1.15e-8 Crohn's disease; CESC cis rs9303280 0.628 rs12939565 chr17:38038389 A/T cg19468946 chr17:37922297 IKZF3 -0.43 -5.82 -0.34 1.71e-8 Self-reported allergy; CESC cis rs77216612 0.877 rs7956514 chr12:12879254 T/G cg04607235 chr12:12878440 APOLD1 -1.04 -16.29 -0.71 8.18e-42 Lymphocyte counts; CESC cis rs9303280 0.806 rs2305480 chr17:38062196 G/A cg19468946 chr17:37922297 IKZF3 -0.39 -5.2 -0.3 4.07e-7 Self-reported allergy; CESC cis rs6951245 0.810 rs117800627 chr7:1081075 G/C cg03188948 chr7:1209495 NA 0.68 6.6 0.38 2.23e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7660520 0.524 rs4862100 chr4:183732709 G/T cg12483801 chr4:183727862 NA 0.76 6.92 0.39 3.38e-11 Pediatric autoimmune diseases; CESC cis rs870825 0.616 rs6852082 chr4:185645783 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs4727027 0.866 rs2373437 chr7:148779032 T/C cg23158103 chr7:148848205 ZNF398 -0.4 -6.44 -0.37 5.45e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg02788857 chr8:22132959 PIWIL2 0.31 5.42 0.32 1.33e-7 Hypertriglyceridemia; CESC cis rs1707322 1.000 rs11211217 chr1:46348229 C/G cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13507888 chr9:132199983 NA 0.55 6.06 0.35 4.57e-9 Gut microbiome composition (summer); CESC trans rs561341 0.714 rs547473 chr17:30297560 T/G cg27661571 chr11:113659931 NA -0.72 -7.36 -0.41 2.36e-12 Hip circumference adjusted for BMI; CESC cis rs1642645 0.793 rs4083557 chr1:42478177 C/T cg16685388 chr1:42384056 HIVEP3 0.38 5.68 0.33 3.57e-8 Left ventricular obstructive tract defect (maternal effect); CESC trans rs1994135 0.617 rs12821909 chr12:33723466 T/C cg26384229 chr12:38710491 ALG10B 0.58 7.82 0.43 1.26e-13 Resting heart rate; CESC cis rs17253792 0.822 rs79398217 chr14:56067350 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.73 0.33 2.69e-8 Putamen volume; CESC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.33 -0.36 1.05e-9 Depression; CESC cis rs17209837 1.000 rs45607141 chr7:87087025 A/G cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC cis rs2439831 0.867 rs6493085 chr15:43654182 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.84 12.1 0.6 4.05e-27 Lung cancer in ever smokers; CESC cis rs4523957 0.583 rs2760739 chr17:2024217 C/T cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7937682 0.562 rs630002 chr11:111377758 G/A cg09085632 chr11:111637200 PPP2R1B -0.65 -8.61 -0.47 6.62e-16 Primary sclerosing cholangitis; CESC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg22442454 chr1:209979470 IRF6 0.43 5.03 0.3 8.93e-7 Cleft lip with or without cleft palate; CESC cis rs3813567 0.759 rs12148319 chr15:78956192 A/G cg05914723 chr15:78953907 NA 0.44 5.66 0.33 4e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs7216064 1.000 rs58551145 chr17:65837235 A/G cg07042672 chr17:66097459 LOC651250 -0.51 -5.23 -0.31 3.46e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg26769984 chr7:1090371 C7orf50 0.65 7.22 0.41 5.64e-12 Bronchopulmonary dysplasia; CESC cis rs950776 0.593 rs481134 chr15:78877563 C/T cg24631222 chr15:78858424 CHRNA5 -0.4 -5.12 -0.3 5.74e-7 Sudden cardiac arrest; CESC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.18 0.4 7.24e-12 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15010184 chr1:23543591 NA 0.54 6.12 0.35 3.28e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg17366294 chr4:99064904 C4orf37 0.55 7.58 0.42 5.91e-13 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.79 0.43 1.51e-13 Prudent dietary pattern; CESC cis rs73019876 0.901 rs1849001 chr19:22130763 C/G cg11619707 chr19:22235551 ZNF257 -0.27 -5.12 -0.3 5.8e-7 Testicular germ cell tumor; CESC cis rs56104184 0.887 rs4801778 chr19:49370609 G/T cg15549821 chr19:49342101 PLEKHA4 -0.56 -6.57 -0.37 2.68e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg22875332 chr1:76189707 ACADM -0.62 -7.23 -0.41 5.23e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4253772 0.591 rs6007727 chr22:46650959 G/A cg09491104 chr22:46646882 C22orf40 -0.59 -9.15 -0.49 1.58e-17 LDL cholesterol;Cholesterol, total; CESC trans rs208520 0.690 rs207096 chr6:66797287 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.82 -0.62 1.32e-29 Exhaled nitric oxide output; CESC cis rs2832191 0.632 rs2246777 chr21:30309586 T/C cg24692254 chr21:30365293 RNF160 -0.97 -16.5 -0.71 1.45e-42 Dental caries; CESC cis rs847577 0.630 rs6969384 chr7:97732842 C/T cg24562669 chr7:97807699 LMTK2 0.81 13.36 0.63 1.77e-31 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01110955 chr16:1706924 CRAMP1L -0.63 -7.18 -0.4 7.06e-12 Gut microbiome composition (summer); CESC cis rs42648 0.869 rs10234301 chr7:89918278 T/C cg23697855 chr7:89950296 NA 0.28 5.37 0.31 1.7e-7 Homocysteine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04880506 chr22:22337034 TOP3B 0.58 6.0 0.35 6.33e-9 Gut microbiome composition (summer); CESC cis rs7659604 0.846 rs60340409 chr4:122666355 G/C cg19671926 chr4:122722719 EXOSC9 -0.49 -5.94 -0.34 9.04e-9 Type 2 diabetes; CESC cis rs2228479 0.850 rs117880578 chr16:89910230 C/G cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs868036 0.958 rs4261478 chr15:68074084 G/A cg08079166 chr15:68083412 MAP2K5 0.44 6.98 0.39 2.39e-11 Restless legs syndrome; CESC cis rs950169 0.920 rs17300048 chr15:84749477 C/T cg17507749 chr15:85114479 UBE2QP1 0.64 7.1 0.4 1.17e-11 Schizophrenia; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg09538139 chr9:127532208 NR6A1 -0.51 -6.21 -0.36 1.99e-9 Psoriatic arthritis; CESC cis rs4555082 0.874 rs4677 chr14:105717279 T/C cg13114125 chr14:105738426 BRF1 -0.81 -10.1 -0.53 1.72e-20 Mean platelet volume;Platelet distribution width; CESC cis rs17253792 0.822 rs74609892 chr14:56053002 G/A cg01858014 chr14:56050164 KTN1 -0.94 -6.94 -0.39 3.01e-11 Putamen volume; CESC cis rs733175 0.855 rs9291641 chr4:10007259 C/T cg11266682 chr4:10021025 SLC2A9 0.39 5.33 0.31 2.1e-7 Psychosis and Alzheimer's disease; CESC cis rs9486715 1.000 rs6905737 chr6:97066659 A/T cg18709589 chr6:96969512 KIAA0776 -0.47 -6.62 -0.38 1.98e-10 Headache; CESC cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg05340658 chr4:99064831 C4orf37 0.79 12.28 0.6 9.45e-28 Colonoscopy-negative controls vs population controls; CESC cis rs12422267 0.623 rs11246919 chr12:132569493 G/T cg09764611 chr12:132620959 NA -0.67 -5.15 -0.3 5.05e-7 Plasma amyloid beta peptide concentrations (ABx-40); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18202577 chr15:65809771 DPP8 0.56 6.11 0.35 3.61e-9 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.08e-9 Aortic root size; CESC cis rs4654899 0.965 rs61779124 chr1:21513306 C/T cg05370193 chr1:21551575 ECE1 0.41 6.25 0.36 1.61e-9 Superior frontal gyrus grey matter volume; CESC trans rs10411161 0.721 rs1433082 chr19:52390726 A/C cg22319618 chr22:45562946 NUP50 0.7 7.31 0.41 3.17e-12 Breast cancer; CESC cis rs12928939 0.517 rs8050058 chr16:71981374 T/G cg03805757 chr16:71968109 PKD1L3 -0.56 -6.33 -0.36 1.04e-9 Post bronchodilator FEV1; CESC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg27170947 chr2:26402098 FAM59B 0.87 9.85 0.52 1.01e-19 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg27347728 chr4:17578864 LAP3 0.5 5.75 0.33 2.49e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3806843 1.000 rs7701755 chr5:140182101 G/T cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.24 -0.31 3.26e-7 Depressive symptoms (multi-trait analysis); CESC cis rs332507 0.789 rs11928787 chr3:124408149 C/T cg05980111 chr3:124395277 KALRN 0.36 5.13 0.3 5.56e-7 Plateletcrit; CESC cis rs4853012 1.000 rs2280643 chr2:74358286 T/C cg01017244 chr2:74357527 NA 0.68 9.44 0.5 1.95e-18 Gestational age at birth (maternal effect); CESC cis rs16854884 0.609 rs9872126 chr3:143683851 G/A cg01302019 chr3:143689584 C3orf58 -0.38 -5.95 -0.34 8.45e-9 Economic and political preferences (feminism/equality); CESC cis rs2573652 0.722 rs12908133 chr15:100544405 G/A cg00587665 chr15:100533223 ADAMTS17 -0.4 -6.48 -0.37 4.5e-10 Height; CESC cis rs2439831 0.681 rs11858152 chr15:43634196 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.91 11.07 0.56 1.12e-23 Lung cancer in ever smokers; CESC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg19193384 chr17:30244184 NA -0.67 -6.96 -0.39 2.6e-11 Hip circumference adjusted for BMI; CESC cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.31 -5.14 -0.3 5.27e-7 Hemoglobin concentration; CESC cis rs250677 1.000 rs190378 chr5:148434275 G/T cg18129178 chr5:148520854 ABLIM3 -0.5 -5.74 -0.33 2.6e-8 Breast cancer; CESC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.93e-7 Lung cancer; CESC cis rs1707322 0.752 rs28890893 chr1:46186576 T/G cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs9929218 0.953 rs12920562 chr16:68737512 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -9.51 -0.5 1.24e-18 Colorectal cancer; CESC cis rs9287719 0.967 rs2287062 chr2:10743191 G/A cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs7772486 0.875 rs1331639 chr6:146431869 A/G cg05347473 chr6:146136440 FBXO30 -0.48 -6.42 -0.37 6.4e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7590368 0.673 rs17365181 chr2:10937980 T/C cg15705551 chr2:10952987 PDIA6 0.54 5.17 0.3 4.51e-7 Educational attainment (years of education); CESC cis rs2294693 0.945 rs9349175 chr6:40982401 T/C cg14418226 chr6:40996092 UNC5CL 0.53 6.06 0.35 4.63e-9 Gastric cancer;Non-cardia gastric cancer; CESC cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg15744005 chr10:104629667 AS3MT 0.33 5.09 0.3 6.89e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg16240275 chr20:61666158 NCRNA00029 0.5 8.89 0.48 9.54e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs116095464 0.558 rs73031482 chr5:227594 G/A cg22857025 chr5:266934 NA -1.26 -18.2 -0.75 1.38e-48 Breast cancer; CESC cis rs67478160 0.643 rs8004408 chr14:104203938 G/A cg08213375 chr14:104286397 PPP1R13B 0.55 11.03 0.56 1.54e-23 Schizophrenia; CESC cis rs6163 0.727 rs284862 chr10:104572081 C/T cg04362960 chr10:104952993 NT5C2 -0.5 -6.85 -0.39 5.11e-11 Waist circumference;Hip circumference; CESC cis rs6732160 0.588 rs10192654 chr2:73370882 A/T cg01422370 chr2:73384389 NA -0.53 -8.49 -0.46 1.51e-15 Intelligence (multi-trait analysis); CESC cis rs10791323 0.604 rs2723605 chr11:133711241 C/G cg15485101 chr11:133734466 NA 0.4 6.48 0.37 4.47e-10 Childhood ear infection; CESC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg04772025 chr11:68637568 NA 0.5 5.73 0.33 2.73e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs854765 0.583 rs7214536 chr17:17852446 G/A cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC cis rs6736093 0.830 rs11680463 chr2:112775611 T/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.34 -0.31 2.03e-7 Coronary artery disease; CESC cis rs3820068 0.603 rs3766163 chr1:15986547 T/C cg17385448 chr1:15911702 AGMAT 0.43 7.2 0.4 6.19e-12 Systolic blood pressure; CESC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg07507251 chr3:52567010 NT5DC2 0.31 5.42 0.32 1.33e-7 Bipolar disorder; CESC cis rs4481887 1.000 rs4244176 chr1:248468231 G/A cg00666640 chr1:248458726 OR2T12 0.39 6.36 0.36 8.71e-10 Common traits (Other); CESC cis rs35110281 0.627 rs7283362 chr21:44973667 C/G cg01579765 chr21:45077557 HSF2BP -0.51 -8.45 -0.46 1.98e-15 Mean corpuscular volume; CESC cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg05585544 chr11:47624801 NA -0.49 -7.25 -0.41 4.56e-12 Subjective well-being; CESC cis rs4332037 0.539 rs11764590 chr7:2032803 C/T cg23422044 chr7:1970798 MAD1L1 -0.48 -5.16 -0.3 4.97e-7 Bipolar disorder; CESC cis rs7692995 1.000 rs7692995 chr4:17936634 T/C cg08925142 chr4:18023851 LCORL -0.46 -5.31 -0.31 2.29e-7 Height; CESC cis rs2072499 0.833 rs2251847 chr1:156204047 G/A cg24450063 chr1:156163899 SLC25A44 0.82 12.61 0.61 7.21e-29 Testicular germ cell tumor; CESC cis rs868036 0.915 rs4489954 chr15:68072075 A/C cg08079166 chr15:68083412 MAP2K5 -0.46 -7.32 -0.41 3.03e-12 Restless legs syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09373211 chr1:154193749 C1orf43;UBAP2L 0.74 8.23 0.45 8.28e-15 Gut microbiome composition (summer); CESC cis rs1538970 0.924 rs4660858 chr1:45936351 G/A cg06784218 chr1:46089804 CCDC17 0.35 5.64 0.33 4.31e-8 Platelet count; CESC cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.78 8.14 0.45 1.51e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg15145296 chr3:125709740 NA -0.51 -5.4 -0.31 1.5e-7 Blood pressure (smoking interaction); CESC cis rs483180 0.511 rs496198 chr1:120207177 A/G cg19096424 chr1:120255104 PHGDH -0.42 -5.08 -0.3 7.2e-7 Macular telangiectasia type 2; CESC cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg15541040 chr2:3486749 NA -0.45 -5.82 -0.34 1.67e-8 Neurofibrillary tangles; CESC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg26335602 chr6:28129616 ZNF389 0.44 5.65 0.33 4.17e-8 Parkinson's disease; CESC cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.03 0.3 9.17e-7 Colonoscopy-negative controls vs population controls; CESC trans rs6600671 1.000 rs10903161 chr1:121178741 A/T cg17023122 chr1:144479586 NA 0.45 6.27 0.36 1.49e-9 Hip geometry; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06943682 chr22:46692606 GTSE1;CN5H6.4 0.55 6.26 0.36 1.58e-9 Gut microbiome composition (summer); CESC cis rs6674176 1.000 rs6674176 chr1:44379957 G/A cg12908607 chr1:44402522 ARTN -0.47 -6.51 -0.37 3.82e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg15763497 chr22:18256852 BID 0.42 6.16 0.35 2.64e-9 Vertical cup-disc ratio; CESC cis rs1348850 0.914 rs8941 chr2:178406481 C/T cg23306229 chr2:178417860 TTC30B 0.65 8.14 0.45 1.57e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs55823223 0.648 rs936394 chr17:73852008 C/A cg23806715 chr17:73775811 H3F3B 0.61 6.68 0.38 1.37e-10 Psoriasis; CESC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg23161317 chr6:28129485 ZNF389 0.51 6.5 0.37 3.98e-10 Depression; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09623457 chr3:183735666 ABCC5 0.43 6.15 0.35 2.88e-9 Gut microbiota (bacterial taxa); CESC cis rs7772486 0.875 rs9403764 chr6:146360582 G/A cg23711669 chr6:146136114 FBXO30 0.85 12.56 0.61 1.02e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg00409905 chr10:38381863 ZNF37A -0.45 -5.87 -0.34 1.28e-8 Extrinsic epigenetic age acceleration; CESC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg26314531 chr2:26401878 FAM59B -0.62 -6.88 -0.39 4.38e-11 Gut microbiome composition (summer); CESC trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg15556689 chr8:8085844 FLJ10661 -0.54 -6.84 -0.39 5.51e-11 Neuroticism; CESC cis rs6867032 1.000 rs4074914 chr5:2020274 C/T cg26168224 chr5:2018326 NA 0.97 19.12 0.76 8.34e-52 Gut microbiome composition (winter); CESC cis rs3736485 0.966 rs7161973 chr15:51854163 T/C cg08986416 chr15:51914746 DMXL2 -0.4 -5.13 -0.3 5.5e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg10150615 chr22:24372951 LOC391322 0.56 7.73 0.43 2.18e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3820928 0.845 rs10165767 chr2:227781863 G/A cg05526886 chr2:227700861 RHBDD1 -0.46 -5.9 -0.34 1.1e-8 Pulmonary function; CESC cis rs11098499 0.710 rs4145952 chr4:120155806 C/A cg09307838 chr4:120376055 NA 0.63 7.8 0.43 1.4e-13 Corneal astigmatism; CESC cis rs1153858 1.000 rs7163720 chr15:45639374 G/A cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg07414643 chr4:187882934 NA 0.55 7.99 0.44 4.15e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg27121462 chr16:89883253 FANCA -0.75 -10.99 -0.56 2.17e-23 Vitiligo; CESC cis rs12325245 0.536 rs35832551 chr16:58591444 G/T cg01152986 chr16:58549298 SETD6 0.89 5.4 0.32 1.45e-7 Schizophrenia; CESC cis rs10751667 0.666 rs11246358 chr11:967349 G/A cg06064525 chr11:970664 AP2A2 -0.5 -9.7 -0.51 3.17e-19 Alzheimer's disease (late onset); CESC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg22823121 chr1:150693482 HORMAD1 -0.5 -7.45 -0.42 1.36e-12 Tonsillectomy; CESC cis rs10870270 1.000 rs10159746 chr10:133742677 C/T cg26149184 chr10:133730230 NA 0.38 5.15 0.3 5.07e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25789201 chr7:72395803 POM121 -0.51 -7.52 -0.42 8.45e-13 Gambling; CESC cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg06766960 chr11:133703094 NA -0.39 -5.49 -0.32 9.51e-8 Childhood ear infection; CESC cis rs1003719 0.788 rs2835578 chr21:38457671 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.67 0.47 4.41e-16 Eye color traits; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg17274400 chr12:8234945 NECAP1 0.47 6.0 0.35 6.45e-9 Attention deficit hyperactivity disorder; CESC cis rs2204008 0.837 rs11519926 chr12:38348992 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.62 0.38 2.03e-10 Bladder cancer; CESC cis rs4722166 0.508 rs2069832 chr7:22767433 A/G cg13104385 chr7:22767384 IL6 0.42 5.83 0.34 1.59e-8 Lung cancer; CESC trans rs1814175 0.645 rs1608632 chr11:49967148 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs72634258 0.945 rs12735338 chr1:8078569 T/C cg00042356 chr1:8021962 PARK7 0.82 7.53 0.42 7.8e-13 Inflammatory bowel disease; CESC cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg16447950 chr5:562315 NA -0.64 -6.86 -0.39 4.95e-11 Lung disease severity in cystic fibrosis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25845374 chr2:119981187 STEAP3 -0.45 -6.3 -0.36 1.25e-9 Ulcerative colitis; CESC cis rs7098414 0.531 rs3844126 chr10:82019997 T/G cg00277334 chr10:82204260 NA -0.45 -5.85 -0.34 1.46e-8 Post bronchodilator FEV1; CESC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg08736216 chr1:53307985 ZYG11A 0.43 7.13 0.4 9.53e-12 Monocyte count; CESC cis rs9814567 1.000 rs9850015 chr3:134269541 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.35 -0.36 9.53e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15921587 chr2:73144353 EMX1 0.66 8.08 0.44 2.28e-14 Gut microbiome composition (summer); CESC cis rs2658782 0.789 rs2605580 chr11:93147054 C/T cg15737290 chr11:93063684 CCDC67 0.39 5.03 0.3 9.19e-7 Pulmonary function decline; CESC cis rs3796352 1.000 rs13072457 chr3:53102389 G/A cg15956490 chr3:53032818 SFMBT1 0.63 5.15 0.3 5.18e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs9399135 0.622 rs3817776 chr6:135256756 C/T cg22676075 chr6:135203613 NA -0.56 -8.44 -0.46 2.16e-15 Red blood cell count; CESC cis rs6540556 0.769 rs6665715 chr1:209931353 A/C cg05527609 chr1:210001259 C1orf107 0.49 6.09 0.35 3.9e-9 Red blood cell count; CESC cis rs11148252 0.595 rs4885117 chr13:53153027 T/C cg00495681 chr13:53174319 NA 0.61 8.44 0.46 2.05e-15 Lewy body disease; CESC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg25204440 chr1:209979598 IRF6 0.63 8.01 0.44 3.76e-14 Cleft lip with or without cleft palate; CESC cis rs11252926 0.966 rs11252923 chr10:566195 G/A cg18196295 chr10:418757 DIP2C -0.49 -5.78 -0.33 2.06e-8 Psychosis in Alzheimer's disease; CESC cis rs2290159 0.800 rs73132351 chr3:12688284 A/G cg23032965 chr3:12705835 RAF1 0.5 5.2 0.3 3.9e-7 Cholesterol, total; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg12791010 chr2:190305806 WDR75 -0.47 -6.27 -0.36 1.44e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg25019033 chr10:957182 NA -0.62 -6.76 -0.38 8.97e-11 Eosinophil percentage of granulocytes; CESC cis rs30380 0.632 rs26496 chr5:96137882 A/G cg16492584 chr5:96139282 ERAP1 -0.48 -6.78 -0.38 7.83e-11 Cerebrospinal fluid biomarker levels; CESC cis rs9682041 0.696 rs11917147 chr3:170088448 C/T cg11886554 chr3:170076028 SKIL 0.7 6.49 0.37 4.1e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg00166722 chr3:10149974 C3orf24 0.46 5.67 0.33 3.7e-8 Alzheimer's disease; CESC cis rs11920090 0.860 rs7646014 chr3:170740071 G/C cg09710316 chr3:170744871 SLC2A2 0.4 5.03 0.3 9.13e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs4253772 0.515 rs77797820 chr22:46771270 C/T cg18190219 chr22:46762943 CELSR1 -0.78 -6.33 -0.36 1.06e-9 LDL cholesterol;Cholesterol, total; CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg09177884 chr7:1199841 ZFAND2A -0.59 -6.53 -0.37 3.28e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11792861 0.888 rs72607168 chr9:111832192 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 5.26 0.31 3.04e-7 Menarche (age at onset); CESC cis rs12701220 0.522 rs12701455 chr7:1055409 A/G cg04025307 chr7:1156635 C7orf50 0.36 5.34 0.31 1.96e-7 Bronchopulmonary dysplasia; CESC cis rs7809950 1.000 rs2712200 chr7:107142435 G/T cg23024343 chr7:107201750 COG5 -0.43 -5.99 -0.35 6.99e-9 Coronary artery disease; CESC cis rs8067545 1.000 rs8067545 chr17:19912710 T/C cg13482628 chr17:19912719 NA 0.46 6.17 0.35 2.55e-9 Schizophrenia; CESC cis rs12971120 0.891 rs12608037 chr18:72169395 A/G cg26446133 chr18:72167187 CNDP2 -0.77 -9.41 -0.5 2.5e-18 Refractive error; CESC cis rs9303280 0.840 rs12939457 chr17:38032188 T/C cg20243544 chr17:37824526 PNMT 0.5 6.45 0.37 5.25e-10 Self-reported allergy; CESC cis rs1801251 0.964 rs13007783 chr2:233566679 G/A cg25237894 chr2:233734115 C2orf82 0.5 8.64 0.47 5.54e-16 Coronary artery disease; CESC trans rs1814175 0.645 rs1851869 chr11:49960552 T/C cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.49e-38 Height; CESC cis rs870825 0.616 rs6419939 chr4:185642869 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs6430585 0.528 rs111682961 chr2:136653848 C/T cg07169764 chr2:136633963 MCM6 1.25 16.8 0.72 1.28e-43 Corneal structure; CESC cis rs7647973 1.000 rs6783003 chr3:49524778 G/C cg06212747 chr3:49208901 KLHDC8B -0.56 -6.93 -0.39 3.22e-11 Menarche (age at onset); CESC cis rs35306767 0.953 rs1106064 chr10:957211 G/A cg10556349 chr10:835070 NA 0.57 5.98 0.34 7.08e-9 Eosinophil percentage of granulocytes; CESC cis rs1874326 0.545 rs6964218 chr7:138112861 A/G cg18008034 chr7:138118925 NA -0.4 -5.16 -0.3 4.79e-7 Quantitative traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04760117 chr10:75900017 AP3M1 -0.58 -6.65 -0.38 1.72e-10 Gut microbiome composition (summer); CESC cis rs10088262 0.629 rs7833650 chr8:124822969 C/T cg20713898 chr8:124780851 FAM91A1 -0.67 -8.75 -0.47 2.52e-16 Pancreatic cancer; CESC cis rs4908760 0.773 rs301805 chr1:8481016 T/G cg00120948 chr1:8484417 RERE -0.37 -5.9 -0.34 1.09e-8 Vitiligo; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17895080 chr13:114096090 ADPRHL1 -0.44 -6.11 -0.35 3.61e-9 Systemic lupus erythematosus; CESC cis rs4295623 0.559 rs4841600 chr8:11688148 T/C cg00262122 chr8:11665843 FDFT1 0.51 6.36 0.36 8.71e-10 Morning vs. evening chronotype; CESC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg22823121 chr1:150693482 HORMAD1 0.39 5.35 0.31 1.93e-7 Melanoma; CESC cis rs9815354 0.812 rs73073233 chr3:42010550 A/G cg03022575 chr3:42003672 ULK4 0.69 6.24 0.36 1.72e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs34779708 0.966 rs12769484 chr10:35465746 G/A cg03585969 chr10:35415529 CREM 0.77 10.34 0.54 2.94e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs614226 1.000 rs12310837 chr12:120880572 C/T cg01236616 chr12:121019343 POP5 1.41 16.05 0.7 5.8e-41 Type 1 diabetes nephropathy; CESC cis rs9911578 1.000 rs172565 chr17:56808996 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.15 0.3 5.07e-7 Intelligence (multi-trait analysis); CESC cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg02297831 chr4:17616191 MED28 0.46 5.83 0.34 1.63e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg06873352 chr17:61820015 STRADA 0.72 12.87 0.62 9.11e-30 Prudent dietary pattern; CESC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg09323728 chr8:95962352 TP53INP1 0.35 7.42 0.41 1.63e-12 Type 2 diabetes; CESC cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg06753689 chr10:1034030 GTPBP4 0.5 5.05 0.3 8.33e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs228437 1.000 rs1535118 chr6:134912447 C/T cg24504307 chr6:134963096 NA 0.58 6.13 0.35 3.17e-9 Melanoma; CESC trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -8.48 -0.46 1.65e-15 Intelligence (multi-trait analysis); CESC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg24549020 chr5:56110836 MAP3K1 0.57 6.52 0.37 3.61e-10 Initial pursuit acceleration; CESC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg26314531 chr2:26401878 FAM59B -0.73 -8.61 -0.47 6.76e-16 Gut microbiome composition (summer); CESC cis rs2742234 0.541 rs61845684 chr10:43744983 T/C cg07801480 chr10:43725741 RASGEF1A -0.41 -5.22 -0.31 3.61e-7 Hirschsprung disease; CESC cis rs7786877 0.583 rs41303510 chr7:100226129 C/T cg27028030 chr7:100209634 MOSPD3 0.58 5.49 0.32 9.24e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs2877832 0.778 rs73603735 chr14:27822378 A/G cg13449535 chr1:1101348 MIR200B 0.55 6.65 0.38 1.67e-10 Diabetes related insulin traits; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09435674 chr3:46933864 PTH1R -0.5 -6.38 -0.36 7.82e-10 Ulcerative colitis; CESC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg00129232 chr17:37814104 STARD3 -0.57 -7.34 -0.41 2.64e-12 Glomerular filtration rate (creatinine); CESC cis rs1904096 0.506 rs8336 chr4:95211610 A/G cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.53 -0.51 1.04e-18 Type 2 diabetes; CESC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg04414720 chr1:150670196 GOLPH3L 0.56 7.46 0.42 1.21e-12 Melanoma; CESC cis rs9611519 0.732 rs1883826 chr22:41703428 G/A cg17376030 chr22:41985996 PMM1 0.48 5.38 0.31 1.6e-7 Neuroticism; CESC cis rs929596 0.561 rs7564935 chr2:234645186 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.53 -6.33 -0.36 1.02e-9 Total bilirubin levels in HIV-1 infection; CESC trans rs11098499 1.000 rs3749591 chr4:120214030 T/G cg25214090 chr10:38739885 LOC399744 0.67 8.98 0.48 5.1e-17 Corneal astigmatism; CESC cis rs10788264 0.569 rs7089468 chr10:124019052 T/C cg09507567 chr10:124027408 NA 0.37 5.55 0.32 6.84e-8 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00846248 chr7:86849067 C7orf23 -0.45 -6.42 -0.37 6.4e-10 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04860312 chr1:209786644 CAMK1G 0.44 6.49 0.37 4.16e-10 Fibrinogen levels; CESC cis rs55692411 0.537 rs35012435 chr3:50031840 C/T cg03060546 chr3:49711283 APEH -0.46 -5.24 -0.31 3.32e-7 Intelligence (multi-trait analysis); CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg15933527 chr12:51632360 DAZAP2 0.49 6.27 0.36 1.43e-9 Attention deficit hyperactivity disorder; CESC cis rs1499614 1.000 rs60326618 chr7:66166358 G/A cg12463550 chr7:65579703 CRCP 0.73 5.73 0.33 2.78e-8 Gout; CESC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg21970626 chr13:21893289 NA -0.44 -6.7 -0.38 1.24e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9399135 0.967 rs2297340 chr6:135376058 T/C cg24558204 chr6:135376177 HBS1L 0.53 7.22 0.41 5.36e-12 Red blood cell count; CESC cis rs2242116 1.000 rs2168443 chr3:46947087 A/T cg02527881 chr3:46936655 PTH1R 0.54 8.25 0.45 7.6e-15 Birth weight; CESC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg17366294 chr4:99064904 C4orf37 0.58 7.75 0.43 1.91e-13 Colonoscopy-negative controls vs population controls; CESC cis rs10838687 0.736 rs4647726 chr11:47245494 A/T cg25783544 chr11:47291846 MADD 0.57 6.54 0.37 3.15e-10 Proinsulin levels; CESC cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg02297831 chr4:17616191 MED28 0.5 6.15 0.35 2.82e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg25405998 chr7:65216604 CCT6P1 0.45 5.11 0.3 6.25e-7 Aortic root size; CESC cis rs2749592 0.588 rs2504144 chr10:38383525 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -8.75 -0.47 2.46e-16 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs66573146 1.000 rs6838250 chr4:6973184 C/G cg07817883 chr1:32538562 TMEM39B 1.43 8.97 0.48 5.56e-17 Granulocyte percentage of myeloid white cells; CESC cis rs7212590 0.748 rs8074843 chr17:57935935 C/G cg20303301 chr17:57937339 TUBD1 -0.53 -5.24 -0.31 3.3e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.85 -12.29 -0.6 9.22e-28 Alzheimer's disease; CESC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 12.88 0.62 8.6e-30 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10573763 chr19:19030094 COPE;DDX49 -0.62 -6.85 -0.39 5.01e-11 Gut microbiome composition (summer); CESC cis rs9815354 0.680 rs73071354 chr3:41829186 C/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs863345 0.967 rs1491196 chr1:158505506 T/A cg12129480 chr1:158549410 OR10X1 -0.32 -6.3 -0.36 1.23e-9 Pneumococcal bacteremia; CESC cis rs36051895 0.623 rs12720 chr9:5231712 T/A cg02405213 chr9:5042618 JAK2 -0.57 -6.98 -0.39 2.31e-11 Pediatric autoimmune diseases; CESC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg00149659 chr3:10157352 C3orf10 0.69 8.14 0.45 1.54e-14 Alzheimer's disease; CESC cis rs116095464 1.000 rs7736 chr5:314935 T/C cg10591111 chr5:226296 SDHA -0.63 -5.89 -0.34 1.16e-8 Breast cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05644321 chr20:20693493 RALGAPA2 0.46 6.68 0.38 1.42e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8064299 0.597 rs6501737 chr17:72780830 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.79 -13.48 -0.64 7.09e-32 Monocyte count; CESC cis rs2050392 0.799 rs303429 chr10:30708441 C/T cg25182066 chr10:30743637 MAP3K8 -0.39 -5.23 -0.31 3.5e-7 Inflammatory bowel disease; CESC cis rs7208859 0.524 rs28760584 chr17:29141017 G/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3820928 0.874 rs7562776 chr2:227806550 G/A cg05526886 chr2:227700861 RHBDD1 -0.39 -5.04 -0.3 8.54e-7 Pulmonary function; CESC cis rs1707322 1.000 rs6429588 chr1:46454058 T/G cg05343316 chr1:45956843 TESK2 0.45 5.54 0.32 7.24e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4851870 1.000 rs12997253 chr2:106444416 T/C cg16077055 chr2:106428750 NCK2 -0.4 -5.13 -0.3 5.61e-7 Addiction; CESC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs3857067 0.806 rs12505596 chr4:95109600 A/G cg11021082 chr4:95130006 SMARCAD1 -0.54 -7.94 -0.44 5.83e-14 QT interval; CESC cis rs10887741 0.624 rs9633742 chr10:89432286 A/G cg13926569 chr10:89418898 PAPSS2 0.46 6.98 0.39 2.36e-11 Exercise (leisure time); CESC cis rs9911578 0.835 rs1990008 chr17:56459408 C/G cg12560992 chr17:57184187 TRIM37 -0.89 -14.57 -0.67 1.04e-35 Intelligence (multi-trait analysis); CESC cis rs911555 0.504 rs8006526 chr14:104075015 T/C cg24130564 chr14:104152367 KLC1 -0.81 -13.18 -0.63 7.32e-31 Intelligence (multi-trait analysis); CESC cis rs11098499 0.738 rs10026493 chr4:120384194 C/G cg09307838 chr4:120376055 NA 0.95 13.79 0.65 5.71e-33 Corneal astigmatism; CESC trans rs7615952 0.932 rs6438948 chr3:125650045 A/T cg07211511 chr3:129823064 LOC729375 1.04 13.77 0.65 6.46e-33 Blood pressure (smoking interaction); CESC cis rs10883723 0.775 rs7917158 chr10:104246471 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.56 0.42 6.55e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs9948 0.655 rs57582887 chr2:97406354 A/C cg01990225 chr2:97406019 LMAN2L -1.02 -7.77 -0.43 1.76e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs6088580 0.609 rs945674 chr20:32964247 G/C cg24642439 chr20:33292090 TP53INP2 -0.53 -6.99 -0.39 2.17e-11 Glomerular filtration rate (creatinine); CESC cis rs11645898 0.935 rs35370634 chr16:72184566 C/T cg14768367 chr16:72042858 DHODH -0.76 -6.49 -0.37 4.28e-10 Blood protein levels; CESC cis rs2354432 0.556 rs2353975 chr1:146837703 C/A cg25205988 chr1:146714368 CHD1L 1.01 8.86 0.48 1.18e-16 Mitochondrial DNA levels; CESC cis rs2717559 0.542 rs11774823 chr8:143887568 G/T cg17252645 chr8:143867129 LY6D -0.32 -5.47 -0.32 1.02e-7 Urinary tract infection frequency; CESC cis rs7264396 0.790 rs6058293 chr20:34248891 T/A cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.77 0.43 1.78e-13 Total cholesterol levels; CESC cis rs1878931 0.520 rs2015640 chr16:3465018 G/C cg22508957 chr16:3507546 NAT15 0.44 5.81 0.34 1.82e-8 Body mass index (adult); CESC cis rs10870270 1.000 rs10159943 chr10:133744744 T/C cg08754478 chr10:133766260 PPP2R2D -0.61 -7.93 -0.44 6.3e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg12386194 chr3:101231763 SENP7 0.45 5.53 0.32 7.8e-8 Colorectal cancer; CESC cis rs9309473 0.607 rs7586361 chr2:73601606 G/A cg20560298 chr2:73613845 ALMS1 -0.52 -7.4 -0.41 1.82e-12 Metabolite levels; CESC cis rs6772849 0.805 rs61159406 chr3:128336009 G/A cg16766828 chr3:128327626 NA -0.31 -5.19 -0.3 4.14e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs9291683 0.632 rs13101785 chr4:10042915 T/A cg11266682 chr4:10021025 SLC2A9 0.67 13.02 0.62 2.72e-30 Bone mineral density; CESC cis rs116095464 0.558 rs62347677 chr5:227453 A/G cg20965017 chr5:231967 SDHA -0.46 -5.26 -0.31 2.96e-7 Breast cancer; CESC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.95 14.15 0.66 3.14e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8060686 0.641 rs73612208 chr16:68206844 G/A cg26727032 chr16:67993705 SLC12A4 -0.51 -6.18 -0.36 2.35e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs12681288 0.723 rs12545453 chr8:970582 C/T cg04851639 chr8:1020857 NA -0.34 -6.88 -0.39 4.39e-11 Schizophrenia; CESC cis rs4949448 1.000 rs4949448 chr1:32062066 A/C cg13919466 chr1:32135498 COL16A1 0.46 8.13 0.45 1.68e-14 Intelligence (multi-trait analysis); CESC trans rs3942852 0.568 rs7479361 chr11:48109793 C/T cg03929089 chr4:120376271 NA -0.69 -8.48 -0.46 1.62e-15 Acute lymphoblastic leukemia (childhood); CESC cis rs3820928 1.000 rs3820928 chr2:227773466 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -5.41 -0.32 1.4e-7 Pulmonary function; CESC cis rs17376456 0.825 rs12716453 chr5:93271697 T/C cg21475434 chr5:93447410 FAM172A 0.74 6.16 0.35 2.67e-9 Diabetic retinopathy; CESC cis rs1348850 0.768 rs57681892 chr2:178357645 G/C cg23306229 chr2:178417860 TTC30B 0.66 8.49 0.46 1.49e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2932538 0.744 rs6537742 chr1:113085197 G/T cg22162597 chr1:113214053 CAPZA1 0.48 5.82 0.34 1.66e-8 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg21138405 chr5:131827807 IRF1 -0.38 -5.64 -0.33 4.36e-8 Breast cancer;Mosquito bite size; CESC cis rs10899021 0.920 rs11236181 chr11:74345823 A/C cg12569118 chr11:74394623 NA -0.55 -5.36 -0.31 1.79e-7 Response to metformin (IC50); CESC cis rs12900413 0.687 rs8035472 chr15:90313432 T/C cg24249390 chr15:90295951 MESP1 -0.41 -5.73 -0.33 2.78e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs6540556 0.608 rs3817821 chr1:209918503 A/T cg05527609 chr1:210001259 C1orf107 -0.42 -5.16 -0.3 4.87e-7 Red blood cell count; CESC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg18446336 chr7:2847575 GNA12 -0.38 -5.91 -0.34 1.02e-8 Height; CESC cis rs4722166 0.603 rs7801406 chr7:22788274 A/G cg05472934 chr7:22766657 IL6 0.85 10.73 0.55 1.49e-22 Lung cancer; CESC cis rs2204008 0.837 rs12366727 chr12:38365748 A/C cg13010199 chr12:38710504 ALG10B 0.53 6.62 0.38 2.03e-10 Bladder cancer; CESC cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg19193384 chr17:30244184 NA -0.74 -6.9 -0.39 3.78e-11 Hip circumference adjusted for BMI; CESC cis rs1348850 0.526 rs2141157 chr2:178374112 C/T cg23306229 chr2:178417860 TTC30B 0.8 7.39 0.41 1.96e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11112613 0.713 rs11112590 chr12:105951376 C/G cg03607813 chr12:105948248 NA -0.57 -6.79 -0.39 7.23e-11 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs977987 0.771 rs4888387 chr16:75389755 T/G cg03315344 chr16:75512273 CHST6 0.39 5.6 0.33 5.36e-8 Dupuytren's disease; CESC cis rs2011503 1.000 rs4808205 chr19:19645493 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.18 0.3 4.31e-7 Bipolar disorder; CESC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg03806693 chr22:41940476 POLR3H 1.16 13.59 0.64 2.85e-32 Crohn's disease;Inflammatory bowel disease; CESC cis rs6460942 1.000 rs62448568 chr7:12407445 A/G cg20607287 chr7:12443886 VWDE -0.8 -9.05 -0.49 3.2e-17 Coronary artery disease; CESC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg17376030 chr22:41985996 PMM1 0.7 7.6 0.42 5.18e-13 Vitiligo; CESC cis rs2455799 0.634 rs62243671 chr3:15921098 C/T cg16303742 chr3:15540471 COLQ -0.37 -5.65 -0.33 4.12e-8 Mean platelet volume; CESC cis rs9790314 0.586 rs16832246 chr3:161109916 A/G cg03342759 chr3:160939853 NMD3 0.41 5.09 0.3 6.8e-7 Morning vs. evening chronotype; CESC cis rs897080 0.515 rs1067337 chr2:44624859 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.35 0.46 3.96e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs62318471 chr4:98925848 G/A cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9902453 0.967 rs9900911 chr17:28330280 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.83 -0.43 1.15e-13 Coffee consumption (cups per day); CESC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.39 -5.11 -0.3 6.29e-7 Bipolar disorder; CESC cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg20307385 chr11:47447363 PSMC3 -0.63 -7.66 -0.43 3.58e-13 Subjective well-being; CESC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg10691866 chr7:65817282 TPST1 0.33 5.52 0.32 8.21e-8 Aortic root size; CESC cis rs3020736 0.500 rs6002614 chr22:42501802 G/A cg04733989 chr22:42467013 NAGA -0.78 -11.9 -0.59 1.87e-26 Autism spectrum disorder or schizophrenia; CESC cis rs72781680 0.848 rs6748727 chr2:24041058 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC trans rs7819412 0.668 rs2409714 chr8:11010118 A/G cg15556689 chr8:8085844 FLJ10661 -0.53 -6.68 -0.38 1.37e-10 Triglycerides; CESC cis rs9905704 0.552 rs8071623 chr17:56621286 G/T cg12560992 chr17:57184187 TRIM37 -0.63 -6.02 -0.35 5.95e-9 Testicular germ cell tumor; CESC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg08968635 chr6:28129556 ZNF389 0.41 5.28 0.31 2.7e-7 Depression; CESC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg04025307 chr7:1156635 C7orf50 -0.45 -5.48 -0.32 9.86e-8 Bronchopulmonary dysplasia; CESC cis rs754466 0.651 rs11002317 chr10:79617648 G/A cg17075019 chr10:79541650 NA -0.87 -13.72 -0.64 1.01e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs963731 0.649 rs212322 chr2:39305928 C/T cg04010122 chr2:39346883 SOS1 -0.65 -5.31 -0.31 2.3e-7 Corticobasal degeneration; CESC cis rs9291683 0.509 rs6849717 chr4:9958719 T/C cg00071950 chr4:10020882 SLC2A9 -0.8 -14.7 -0.67 3.54e-36 Bone mineral density; CESC cis rs10870270 1.000 rs10870270 chr10:133754334 G/A cg26149184 chr10:133730230 NA 0.38 5.22 0.31 3.7e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs727505 1.000 rs10271646 chr7:124549573 T/C cg23710748 chr7:124431027 NA -0.4 -6.39 -0.37 7.51e-10 Lewy body disease; CESC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg03806693 chr22:41940476 POLR3H -1.12 -13.95 -0.65 1.55e-33 Vitiligo; CESC cis rs2637266 0.756 rs846623 chr10:78542819 C/T cg18941641 chr10:78392320 NA 0.41 7.79 0.43 1.56e-13 Pulmonary function; CESC cis rs1499614 0.803 rs1922723 chr7:66175063 C/T cg18252515 chr7:66147081 NA -1.42 -14.62 -0.67 6.69e-36 Gout; CESC cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg01579765 chr21:45077557 HSF2BP -0.59 -10.14 -0.53 1.28e-20 Mean corpuscular volume; CESC cis rs926392 0.547 rs8118808 chr20:37674996 C/G cg16355469 chr20:37678765 NA 0.51 6.2 0.36 2.17e-9 Dialysis-related mortality; CESC cis rs10958542 0.638 rs10958540 chr8:39081821 A/G cg04904469 chr8:38845670 HTRA4 -0.32 -5.15 -0.3 4.97e-7 Interleukin-12p70 levels; CESC cis rs2228479 1.000 rs62052213 chr16:89991963 C/T cg14709524 chr16:89940631 TCF25 0.85 6.04 0.35 5.29e-9 Skin colour saturation; CESC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg04944784 chr2:26401820 FAM59B 0.75 8.12 0.45 1.72e-14 Gut microbiome composition (summer); CESC cis rs2235642 0.750 rs763152 chr16:1658056 T/C cg03715980 chr16:1756201 MAPK8IP3 0.42 5.61 0.33 5.02e-8 Coronary artery disease; CESC cis rs1461503 0.966 rs11218910 chr11:122842861 G/A cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs9911578 0.935 rs34523895 chr17:57034095 T/C cg05425664 chr17:57184151 TRIM37 -0.4 -5.47 -0.32 1.04e-7 Intelligence (multi-trait analysis); CESC cis rs933688 0.938 rs6869048 chr5:90664322 G/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.96 12.92 0.62 6.09e-30 Smoking behavior; CESC cis rs8170 0.603 rs1544940 chr19:17414843 A/T cg04749549 chr19:17459798 NA -0.35 -5.61 -0.33 5.01e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CESC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.09 0.6 4.37e-27 Alzheimer's disease; CESC cis rs12477438 0.765 rs13390672 chr2:99589829 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs4888262 0.545 rs4588013 chr16:74703388 C/T cg01733217 chr16:74700730 RFWD3 0.88 12.23 0.6 1.47e-27 Testicular germ cell tumor; CESC cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg24110177 chr3:50126178 RBM5 0.51 6.95 0.39 2.76e-11 Intelligence (multi-trait analysis); CESC cis rs9614461 0.702 rs16993867 chr22:45733199 A/G cg23503501 chr22:45809793 SMC1B;RIBC2 0.61 6.6 0.38 2.23e-10 Tonsillectomy; CESC cis rs9611519 0.732 rs1883826 chr22:41703428 G/A cg06481639 chr22:41940642 POLR3H -0.52 -5.74 -0.33 2.57e-8 Neuroticism; CESC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg04772025 chr11:68637568 NA 0.56 6.47 0.37 4.68e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6580649 0.941 rs72644843 chr12:48465061 A/G cg05342945 chr12:48394962 COL2A1 0.51 5.91 0.34 1.07e-8 Lung cancer; CESC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg00684032 chr4:1343700 KIAA1530 0.39 5.43 0.32 1.27e-7 Obesity-related traits; CESC cis rs73001065 1.000 rs56255430 chr19:19477877 A/C cg03709012 chr19:19516395 GATAD2A 0.95 5.91 0.34 1.07e-8 LDL cholesterol; CESC cis rs9399137 0.507 rs11754021 chr6:135308375 A/G cg24558204 chr6:135376177 HBS1L 0.7 9.61 0.51 5.93e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.2.3422646F chr2:169470259 LASS6 -0.55 -6.38 -0.36 7.91e-10 Gut microbiome composition (summer); CESC cis rs1832871 0.672 rs56326208 chr6:158762944 C/T cg07165851 chr6:158734300 TULP4 0.58 6.19 0.36 2.31e-9 Height; CESC cis rs11792861 0.781 rs72607159 chr9:111764270 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.53 6.83 0.39 5.63e-11 Menarche (age at onset); CESC cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg21573476 chr21:45109991 RRP1B -0.49 -6.9 -0.39 3.77e-11 Mean corpuscular volume; CESC cis rs8014204 0.836 rs7150254 chr14:75299101 G/A cg08847533 chr14:75593920 NEK9 0.47 6.01 0.35 6.18e-9 Caffeine consumption; CESC cis rs2760061 0.626 rs1636192 chr1:228124688 A/G cg01973587 chr1:228161476 NA 0.38 5.84 0.34 1.49e-8 Diastolic blood pressure; CESC cis rs7560272 0.723 rs1083919 chr2:73713863 C/G cg20560298 chr2:73613845 ALMS1 0.51 7.22 0.41 5.48e-12 Schizophrenia; CESC cis rs6463523 0.864 rs73047957 chr7:759373 A/T cg11064039 chr7:766100 PRKAR1B;HEATR2 1.0 15.85 0.7 3.03e-40 Subjective well-being; CESC cis rs4919694 0.808 rs4918001 chr10:105013147 G/T cg04362960 chr10:104952993 NT5C2 -0.8 -6.85 -0.39 5.28e-11 Arsenic metabolism; CESC cis rs3815700 1.000 rs8104726 chr19:33094675 G/A cg02997394 chr19:33096574 ANKRD27 0.71 7.07 0.4 1.39e-11 Eosinophilic esophagitis; CESC cis rs12477438 0.700 rs10190421 chr2:99670711 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs6686643 0.630 rs7554034 chr1:165610464 G/A cg19407955 chr1:165599744 MGST3 -0.52 -5.24 -0.31 3.33e-7 Total ventricular volume; CESC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 10.05 0.53 2.43e-20 Alzheimer's disease; CESC cis rs1559088 1.000 rs7260051 chr19:33550111 C/A cg17764715 chr19:33622953 WDR88 0.45 5.67 0.33 3.76e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg11939075 chr4:83956728 COPS4 0.52 6.77 0.38 8.29e-11 Recombination measurement; CESC cis rs11098499 0.779 rs7356491 chr4:120381974 C/T cg24375607 chr4:120327624 NA 0.44 5.51 0.32 8.65e-8 Corneal astigmatism; CESC cis rs57506017 0.585 rs4721059 chr7:12267495 C/G cg23422036 chr7:12250390 TMEM106B -0.39 -5.29 -0.31 2.51e-7 Neuroticism; CESC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.72 0.38 1.09e-10 Bipolar disorder; CESC cis rs11608355 0.515 rs3742018 chr12:109949134 C/T cg05360138 chr12:110035743 NA 0.8 8.72 0.47 3.14e-16 Neuroticism; CESC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg16325326 chr1:53192061 ZYG11B -0.81 -12.88 -0.62 8.6e-30 Monocyte count; CESC cis rs2836633 0.929 rs62217519 chr21:40034390 G/A cg05519781 chr21:40033154 ERG 0.79 13.58 0.64 3e-32 Coronary artery disease; CESC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.1e-18 Prudent dietary pattern; CESC cis rs2742234 0.541 rs10793427 chr10:43747443 G/A cg07801480 chr10:43725741 RASGEF1A -0.41 -5.28 -0.31 2.75e-7 Hirschsprung disease; CESC cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg02574844 chr11:5959923 NA -0.46 -5.73 -0.33 2.76e-8 DNA methylation (variation); CESC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg22535103 chr8:58192502 C8orf71 -1.03 -12.84 -0.62 1.16e-29 Developmental language disorder (linguistic errors); CESC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg25767906 chr1:53392781 SCP2 -0.52 -7.16 -0.4 7.76e-12 Monocyte count; CESC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg22535103 chr8:58192502 C8orf71 -0.92 -9.62 -0.51 5.68e-19 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg25036284 chr2:26402008 FAM59B 0.89 9.95 0.52 5.09e-20 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -6.96 -0.39 2.66e-11 Developmental language disorder (linguistic errors); CESC cis rs10791111 1 rs10791111 chr11:130856099 T/G cg14779329 chr11:130786720 SNX19 0.33 5.06 0.3 7.68e-7 Autism spectrum disorder or schizophrenia; CESC cis rs362296 0.511 rs2857861 chr4:3323767 C/T cg08886695 chr4:3369023 RGS12 -0.47 -6.78 -0.38 7.57e-11 Parental longevity (mother's age at death); CESC cis rs7267979 1.000 rs6050564 chr20:25344231 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.07 -0.74 3.95e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs4237845 0.742 rs3751330 chr12:58290226 T/C cg02175503 chr12:58329896 NA 0.63 9.07 0.49 2.83e-17 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01472951 chr12:5603816 NTF3 0.45 6.02 0.35 5.77e-9 Fibrinogen levels; CESC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg03396347 chr1:1875803 NA -0.42 -6.52 -0.37 3.62e-10 Body mass index; CESC cis rs7084402 0.935 rs12263522 chr10:60343527 C/A cg07615347 chr10:60278583 BICC1 0.56 8.67 0.47 4.26e-16 Refractive error; CESC cis rs7605827 0.930 rs9287660 chr2:15595767 C/A cg19274914 chr2:15703543 NA 0.34 6.12 0.35 3.4e-9 Educational attainment (years of education); CESC cis rs8112211 0.911 rs8106895 chr19:38848861 C/G cg14299480 chr19:38876666 GGN -0.41 -5.05 -0.3 8.09e-7 Blood protein levels; CESC cis rs3126085 0.935 rs4845745 chr1:152185184 C/T cg26876637 chr1:152193138 HRNR 0.48 5.44 0.32 1.21e-7 Atopic dermatitis; CESC cis rs6502050 0.871 rs7226049 chr17:80071049 A/G cg23985595 chr17:80112537 CCDC57 0.38 5.99 0.35 6.82e-9 Life satisfaction; CESC cis rs6121246 0.609 rs6060627 chr20:30262159 C/T cg13852791 chr20:30311386 BCL2L1 0.78 9.96 0.52 4.55e-20 Mean corpuscular hemoglobin; CESC trans rs116095464 0.558 rs61689490 chr5:224904 T/C cg00938859 chr5:1591904 SDHAP3 0.61 6.78 0.38 7.58e-11 Breast cancer; CESC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.23 0.53 6.6e-21 Prudent dietary pattern; CESC cis rs10254118 0.730 rs6961517 chr7:133130940 G/T cg10665199 chr7:133106180 EXOC4 0.55 7.4 0.41 1.78e-12 Intelligence (multi-trait analysis); CESC cis rs34779708 0.897 rs4934529 chr10:35302376 T/A cg03585969 chr10:35415529 CREM 0.76 10.03 0.52 2.79e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs11098499 0.754 rs938056 chr4:120237453 C/T cg09307838 chr4:120376055 NA 0.81 10.89 0.56 4.41e-23 Corneal astigmatism; CESC cis rs2072499 0.966 rs6427304 chr1:156156789 A/G cg24450063 chr1:156163899 SLC25A44 1.07 21.09 0.79 1.23e-58 Testicular germ cell tumor; CESC cis rs9611565 0.592 rs12484254 chr22:41962003 T/A cg06481639 chr22:41940642 POLR3H -0.57 -6.38 -0.36 7.88e-10 Vitiligo; CESC cis rs9916302 0.861 rs12150493 chr17:37586154 T/C cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 4.03e-10 Glomerular filtration rate (creatinine); CESC cis rs1904096 0.506 rs4693378 chr4:95168552 A/T cg11021082 chr4:95130006 SMARCAD1 -0.68 -11.1 -0.56 9.37e-24 Type 2 diabetes; CESC cis rs7264396 0.563 rs2425119 chr20:34324216 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.88e-22 Total cholesterol levels; CESC cis rs9291683 0.588 rs12507330 chr4:10002195 G/A cg11266682 chr4:10021025 SLC2A9 0.64 12.68 0.61 4.08e-29 Bone mineral density; CESC cis rs6500395 1.000 rs36077931 chr16:48594221 A/G cg04672837 chr16:48644449 N4BP1 0.5 6.23 0.36 1.78e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6714710 0.535 rs3192177 chr2:98354511 G/A cg26665480 chr2:98280029 ACTR1B 0.59 7.59 0.42 5.34e-13 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.04 -0.3 8.58e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg05863683 chr7:1912471 MAD1L1 -0.4 -6.02 -0.35 5.94e-9 Bipolar disorder and schizophrenia; CESC cis rs11690935 0.959 rs10207085 chr2:172585885 T/G cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.97 -0.68 4e-37 Schizophrenia; CESC cis rs6460942 0.591 rs6942551 chr7:12338356 C/T cg20607287 chr7:12443886 VWDE -0.59 -6.5 -0.37 4.02e-10 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12205742 chr18:68097929 NA -0.48 -6.66 -0.38 1.58e-10 Gut microbiota (bacterial taxa); CESC cis rs9556958 0.527 rs9517313 chr13:99105892 C/G cg07423050 chr13:99094983 FARP1 0.28 5.29 0.31 2.52e-7 Educational attainment (years of education); CESC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg00149659 chr3:10157352 C3orf10 0.75 9.34 0.5 4.04e-18 Alzheimer's disease; CESC cis rs60154123 0.615 rs701943 chr1:210425727 A/G cg21951975 chr1:209979733 IRF6 -0.48 -6.65 -0.38 1.67e-10 Coronary artery disease; CESC trans rs11098499 0.754 rs2964 chr4:120240131 T/C cg25214090 chr10:38739885 LOC399744 0.61 8.51 0.46 1.33e-15 Corneal astigmatism; CESC cis rs533123 0.816 rs569356 chr1:29136686 A/G cg08366446 chr1:29138936 OPRD1 -0.51 -5.03 -0.3 8.87e-7 Schizophrenia; CESC cis rs17253792 0.822 rs10483645 chr14:56103766 G/T cg01858014 chr14:56050164 KTN1 -0.96 -7.52 -0.42 8.3e-13 Putamen volume; CESC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg06456125 chr7:65229604 NA 0.41 5.27 0.31 2.8e-7 Calcium levels; CESC cis rs2276314 1.000 rs9304153 chr18:33562150 T/C cg05985134 chr18:33552581 C18orf21 0.63 7.17 0.4 7.56e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs9640161 0.750 rs1983440 chr7:150023941 G/C cg13722127 chr7:150037890 RARRES2 0.34 5.12 0.3 6e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs4909189 1.000 rs62493651 chr7:158135592 T/C cg25566285 chr7:158114605 PTPRN2 0.44 5.97 0.34 7.51e-9 Response to amphetamines; CESC cis rs57244997 0.725 rs73030431 chr6:162439575 G/A cg17173639 chr6:162384350 PARK2 -0.45 -5.19 -0.3 4.15e-7 Mosquito bite size; CESC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg23758822 chr17:41437982 NA 1.05 16.08 0.7 4.39e-41 Menopause (age at onset); CESC cis rs10751667 0.961 rs7395928 chr11:952605 T/G cg20946044 chr11:1010712 AP2A2 -0.41 -5.5 -0.32 8.87e-8 Alzheimer's disease (late onset); CESC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12882762 chr14:53196687 STYX -0.5 -6.36 -0.36 8.94e-10 Fibrinogen levels; CESC cis rs2204008 0.745 rs8189516 chr12:38239084 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.52 1.51e-19 Bladder cancer; CESC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg22875332 chr1:76189707 ACADM -0.61 -6.43 -0.37 6.02e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2000999 0.515 rs2854956 chr16:72115238 A/T cg16558253 chr16:72132732 DHX38 -0.6 -9.28 -0.5 6.21e-18 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC cis rs8141529 0.632 rs5762803 chr22:29193638 G/C cg02153584 chr22:29168773 CCDC117 0.68 9.39 0.5 2.95e-18 Lymphocyte counts; CESC trans rs61931739 0.500 rs11053271 chr12:34545407 C/A cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC cis rs4523957 0.651 rs9906968 chr17:2077493 G/C cg16513277 chr17:2031491 SMG6 -0.71 -10.17 -0.53 1.04e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg27266027 chr21:40555129 PSMG1 -0.48 -5.96 -0.34 7.94e-9 Cognitive function; CESC cis rs684232 0.602 rs10521107 chr17:511156 G/A cg15660573 chr17:549704 VPS53 -0.82 -11.93 -0.59 1.53e-26 Prostate cancer; CESC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg07701084 chr6:150067640 NUP43 0.43 5.85 0.34 1.45e-8 Lung cancer; CESC cis rs6754311 0.510 rs1374329 chr2:136421323 A/G cg15123519 chr2:136567270 LCT -0.32 -5.18 -0.3 4.41e-7 Mosquito bite size; CESC cis rs6991838 0.584 rs7836349 chr8:66503563 A/G cg13398993 chr8:66546079 ARMC1 -0.48 -5.85 -0.34 1.45e-8 Intelligence (multi-trait analysis); CESC cis rs12586317 0.553 rs78124218 chr14:35570606 G/A cg16230307 chr14:35515116 FAM177A1 0.92 9.84 0.52 1.12e-19 Psoriasis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03734322 chr17:1532856 SLC43A2 0.5 6.62 0.38 2.04e-10 Gut microbiota (bacterial taxa); CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg16132339 chr22:24313637 DDTL;DDT 0.42 6.34 0.36 9.7e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs698813 0.756 rs2592196 chr2:44605522 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.44 0.32 1.18e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg24733560 chr20:60626293 TAF4 0.47 6.75 0.38 9.09e-11 Body mass index; CESC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg18252515 chr7:66147081 NA 0.43 5.73 0.33 2.67e-8 Aortic root size; CESC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.93 0.34 9.38e-9 Bipolar disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13808088 chr2:74334539 TET3 0.43 6.44 0.37 5.57e-10 Gut microbiota (bacterial taxa); CESC cis rs72781680 0.898 rs72786286 chr2:24074659 T/A cg08917208 chr2:24149416 ATAD2B 0.93 8.48 0.46 1.57e-15 Lymphocyte counts; CESC trans rs1814175 0.781 rs11040681 chr11:49981654 G/T cg15704280 chr7:45808275 SEPT13 -1.03 -20.41 -0.78 2.75e-56 Height; CESC trans rs3749237 0.964 rs11714957 chr3:49776178 C/T cg21659725 chr3:3221576 CRBN 0.54 6.48 0.37 4.54e-10 Resting heart rate; CESC cis rs6785206 0.892 rs2712429 chr3:128336221 A/C cg16766828 chr3:128327626 NA -0.63 -6.46 -0.37 4.93e-10 Lymphocyte percentage of white cells; CESC cis rs11048434 0.673 rs1124402 chr12:9062606 C/T cg23795048 chr12:9217529 LOC144571 0.36 5.68 0.33 3.52e-8 Sjögren's syndrome; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06746101 chr15:79603771 TMED3 -0.42 -6.01 -0.35 5.99e-9 Gambling; CESC cis rs76419734 0.510 rs2216516 chr4:106749857 G/C cg24545054 chr4:106630052 GSTCD;INTS12 -0.63 -6.38 -0.36 7.88e-10 Post bronchodilator FEV1; CESC cis rs3845702 1.000 rs9989852 chr2:180839707 G/A cg01881094 chr2:180872142 CWC22 -0.68 -7.29 -0.41 3.63e-12 Schizophrenia; CESC cis rs6750795 0.569 rs1667305 chr2:232403829 A/G cg19187155 chr2:232395269 NMUR1 0.64 11.51 0.58 3.87e-25 Height; CESC cis rs10927875 0.632 rs1122068 chr1:16127480 G/C cg21385522 chr1:16154831 NA -1.03 -16.84 -0.72 9.42e-44 Dilated cardiomyopathy; CESC cis rs35110281 0.774 rs141521 chr21:44963686 G/A cg21573476 chr21:45109991 RRP1B -0.41 -5.69 -0.33 3.34e-8 Mean corpuscular volume; CESC cis rs965469 1.000 rs6051808 chr20:3350697 A/T cg25506879 chr20:3388711 C20orf194 -0.57 -6.12 -0.35 3.41e-9 IFN-related cytopenia; CESC cis rs7584330 0.737 rs6431540 chr2:238360966 T/C cg14458575 chr2:238380390 NA 0.58 8.09 0.45 2.14e-14 Prostate cancer; CESC trans rs804280 0.509 rs13268030 chr8:11783073 C/T cg15556689 chr8:8085844 FLJ10661 0.5 6.14 0.35 2.93e-9 Myopia (pathological); CESC cis rs9303401 0.573 rs34717648 chr17:56886624 T/A cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.43 0.61 2.98e-28 Cognitive test performance; CESC cis rs1975974 1.000 rs7224508 chr17:21722352 T/A cg18423549 chr17:21743878 NA -0.56 -8.08 -0.44 2.36e-14 Psoriasis; CESC cis rs6460942 0.597 rs12699388 chr7:12536336 T/C cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg11965913 chr1:205819406 PM20D1 0.43 6.15 0.35 2.9e-9 Prostate-specific antigen levels; CESC cis rs910316 0.935 rs175448 chr14:75591071 G/A cg11812906 chr14:75593930 NEK9 -0.87 -15.0 -0.68 3.17e-37 Height; CESC cis rs453301 0.653 rs7016139 chr8:8895470 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -6.3 -0.36 1.22e-9 Joint mobility (Beighton score); CESC cis rs4692589 1.000 rs4692785 chr4:170938593 C/T cg19918862 chr4:170955249 NA 0.35 5.49 0.32 9.23e-8 Anxiety disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15238519 chr22:50683529 TUBGCP6 -0.39 -6.07 -0.35 4.41e-9 Gambling; CESC cis rs6541297 0.645 rs666718 chr1:230313662 A/G cg20703242 chr1:230279135 GALNT2 -0.43 -5.6 -0.33 5.46e-8 Coronary artery disease; CESC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg21951975 chr1:209979733 IRF6 0.58 9.08 0.49 2.56e-17 Cleft lip with or without cleft palate; CESC cis rs1348850 0.567 rs12994392 chr2:178536640 A/G cg22681709 chr2:178499509 PDE11A -0.48 -7.68 -0.43 3e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1691799 0.867 rs1027401 chr12:66760892 C/G cg16791601 chr12:66731901 HELB -0.77 -13.33 -0.63 2.24e-31 White blood cell count (basophil); CESC cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg17366294 chr4:99064904 C4orf37 0.62 8.89 0.48 9.9e-17 Colonoscopy-negative controls vs population controls; CESC cis rs3820928 1.000 rs7592387 chr2:227777095 A/G cg05526886 chr2:227700861 RHBDD1 -0.44 -5.75 -0.33 2.45e-8 Pulmonary function; CESC cis rs6835098 0.924 rs12639929 chr4:174156538 C/T cg08422745 chr4:174089978 GALNT7 -0.76 -10.21 -0.53 7.67e-21 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs7116495 0.609 rs11235444 chr11:71831859 G/A cg07596299 chr11:71824057 C11orf51 0.84 5.26 0.31 2.9e-7 Severe influenza A (H1N1) infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17400366 chr19:10420311 ZGLP1 0.41 6.07 0.35 4.52e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18045461 chr22:29601862 EMID1 0.57 6.21 0.36 2.09e-9 Gut microbiome composition (summer); CESC cis rs7523050 0.730 rs7519107 chr1:109399367 A/C cg08274380 chr1:109419600 GPSM2 0.83 5.58 0.32 5.89e-8 Fat distribution (HIV); CESC cis rs300703 0.935 rs7568664 chr2:280939 A/G cg21211680 chr2:198530 NA 0.86 7.32 0.41 2.89e-12 Blood protein levels; CESC cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.61 0.47 6.66e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs7589728 1.000 rs12473740 chr2:88527647 A/G cg04511125 chr2:88470314 THNSL2 0.53 5.31 0.31 2.37e-7 Plasma clusterin levels; CESC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg00149659 chr3:10157352 C3orf10 0.69 8.03 0.44 3.14e-14 Alzheimer's disease; CESC trans rs116095464 0.510 rs7714944 chr5:231765 C/T cg00938859 chr5:1591904 SDHAP3 0.66 7.22 0.41 5.41e-12 Breast cancer; CESC cis rs17253792 0.822 rs10143002 chr14:56074278 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.9 0.34 1.12e-8 Putamen volume; CESC cis rs752010 0.684 rs10789402 chr1:42084649 A/G cg06885757 chr1:42089581 HIVEP3 0.51 8.84 0.48 1.38e-16 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9399135 0.622 rs3817776 chr6:135256756 C/T cg24558204 chr6:135376177 HBS1L -0.51 -7.15 -0.4 8.26e-12 Red blood cell count; CESC cis rs826838 0.935 rs11168761 chr12:38997211 C/A cg13010199 chr12:38710504 ALG10B 0.6 8.42 0.46 2.45e-15 Heart rate; CESC cis rs12478296 0.685 rs67829386 chr2:242992276 T/A cg06360820 chr2:242988706 NA -0.81 -9.49 -0.5 1.36e-18 Obesity-related traits; CESC cis rs2243480 1.000 rs1796228 chr7:66033084 G/A cg12463550 chr7:65579703 CRCP 0.72 5.62 0.33 4.87e-8 Diabetic kidney disease; CESC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg23281280 chr6:28129359 ZNF389 0.5 6.56 0.37 2.75e-10 Parkinson's disease; CESC cis rs3857536 0.740 rs7756519 chr6:66892275 A/G cg07460842 chr6:66804631 NA -0.4 -5.23 -0.31 3.47e-7 Blood trace element (Cu levels); CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg05564831 chr3:52568323 NT5DC2 0.47 7.98 0.44 4.48e-14 Bipolar disorder; CESC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.44 -5.84 -0.34 1.49e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg09359103 chr1:154839909 KCNN3 -0.65 -12.4 -0.61 3.83e-28 Prostate cancer; CESC cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg19077165 chr18:44547161 KATNAL2 0.49 6.72 0.38 1.12e-10 Personality dimensions; CESC cis rs2486288 0.656 rs7165039 chr15:45570413 C/G cg09092052 chr15:45571596 NA 0.45 5.33 0.31 2.14e-7 Glomerular filtration rate; CESC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.65 0.38 1.63e-10 Bipolar disorder; CESC cis rs854765 0.583 rs5002487 chr17:17832460 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.6 0.38 2.21e-10 Total body bone mineral density; CESC cis rs9649465 0.561 rs603060 chr7:123427568 A/G cg03229431 chr7:123269106 ASB15 -0.43 -5.77 -0.33 2.15e-8 Migraine; CESC cis rs7927771 0.524 rs7929014 chr11:47776283 C/T cg18512352 chr11:47633146 NA 0.34 5.24 0.31 3.22e-7 Subjective well-being; CESC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.45 -5.6 -0.33 5.33e-8 Tonsillectomy; CESC cis rs35110281 0.686 rs162399 chr21:44950020 G/A cg21573476 chr21:45109991 RRP1B -0.41 -5.69 -0.33 3.38e-8 Mean corpuscular volume; CESC cis rs10129255 0.500 rs59939897 chr14:107191651 A/G cg07958169 chr14:107095056 NA -0.54 -8.28 -0.45 5.93e-15 Kawasaki disease; CESC trans rs1728785 1.000 rs1645938 chr16:68595197 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.84 0.43 1.09e-13 Ulcerative colitis; CESC cis rs4253772 0.720 rs4253778 chr22:46630634 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.55 6.4 0.37 7.06e-10 LDL cholesterol;Cholesterol, total; CESC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg23758822 chr17:41437982 NA 1.0 14.9 0.68 6.88e-37 Menopause (age at onset); CESC cis rs7246657 0.882 rs28623164 chr19:37913453 G/A cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.69e-9 Coronary artery calcification; CESC cis rs317689 0.513 rs529268 chr12:69687051 G/A cg20891283 chr12:69753455 YEATS4 0.58 7.3 0.41 3.39e-12 Response to diuretic therapy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24853765 chr1:109584962 WDR47 0.66 7.87 0.44 8.86e-14 Gut microbiome composition (summer); CESC cis rs2425143 1.000 rs2425141 chr20:34350123 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.96 -0.44 5.07e-14 Blood protein levels; CESC cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg21475434 chr5:93447410 FAM172A -0.76 -6.99 -0.39 2.19e-11 Diabetic retinopathy; CESC cis rs13242816 1.000 rs56250718 chr7:116103303 A/G cg04696780 chr7:116139425 CAV2 -0.62 -5.69 -0.33 3.31e-8 P wave duration; CESC cis rs4654899 0.865 rs3856173 chr1:21114833 C/T cg05370193 chr1:21551575 ECE1 0.35 5.28 0.31 2.74e-7 Superior frontal gyrus grey matter volume; CESC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg09640425 chr7:158790006 NA -0.38 -5.89 -0.34 1.18e-8 Facial morphology (factor 20); CESC cis rs2298450 0.717 rs2835330 chr21:37631173 G/A cg02919814 chr21:37666008 DOPEY2 -0.38 -5.03 -0.3 9.06e-7 Schizophrenia; CESC cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.82 -12.11 -0.6 3.74e-27 Systemic lupus erythematosus; CESC cis rs9300255 0.568 rs1790090 chr12:123633424 G/A cg00376283 chr12:123451042 ABCB9 0.71 8.76 0.47 2.38e-16 Neutrophil percentage of white cells; CESC cis rs7193541 0.965 rs4402594 chr16:74701360 C/T cg01733217 chr16:74700730 RFWD3 0.89 13.1 0.63 1.44e-30 Multiple myeloma; CESC cis rs9911578 0.967 rs4076229 chr17:56937256 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 3.04e-7 Intelligence (multi-trait analysis); CESC cis rs7772486 0.790 rs7742333 chr6:146159029 A/G cg05347473 chr6:146136440 FBXO30 -0.51 -6.36 -0.36 8.94e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs80130819 0.748 rs2130096 chr12:48742489 A/G cg05342945 chr12:48394962 COL2A1 -0.53 -5.67 -0.33 3.64e-8 Prostate cancer; CESC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg03188948 chr7:1209495 NA 0.73 7.02 0.4 1.85e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3857536 0.813 rs9363554 chr6:66930183 A/G cg07460842 chr6:66804631 NA -0.41 -5.19 -0.3 4.18e-7 Blood trace element (Cu levels); CESC cis rs9815354 0.812 rs73828283 chr3:41835099 T/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6570726 0.935 rs436212 chr6:145849400 G/A cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 2e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs7789940 1.000 rs11765693 chr7:75985373 A/G cg10167463 chr7:75959203 YWHAG -0.56 -7.09 -0.4 1.23e-11 Multiple sclerosis; CESC cis rs644799 0.544 rs1150360 chr11:95512060 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.61 8.27 0.45 6.69e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs2727020 0.634 rs11040331 chr11:49345726 T/C cg03929089 chr4:120376271 NA -0.64 -6.89 -0.39 3.95e-11 Coronary artery disease; CESC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg18876405 chr7:65276391 NA 0.47 6.22 0.36 1.88e-9 Aortic root size; CESC cis rs1401999 1.000 rs4148571 chr3:183720576 A/C cg01324343 chr3:183735012 ABCC5 0.65 13.72 0.64 1e-32 Anterior chamber depth; CESC cis rs2952156 0.920 rs2934956 chr17:37830447 T/A cg00129232 chr17:37814104 STARD3 -0.79 -11.45 -0.58 6.45e-25 Asthma; CESC cis rs4319547 0.695 rs4758643 chr12:122924819 A/T cg05707623 chr12:122985044 ZCCHC8 -0.54 -6.14 -0.35 2.93e-9 Body mass index; CESC cis rs367943 0.871 rs348938 chr5:112825032 C/A cg12552261 chr5:112820674 MCC -0.59 -7.57 -0.42 6.04e-13 Type 2 diabetes; CESC cis rs7772486 0.754 rs13214277 chr6:146136125 G/T cg05347473 chr6:146136440 FBXO30 0.57 7.31 0.41 3.12e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg01786151 chr1:41347977 NA -0.51 -7.11 -0.4 1.11e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs28489187 0.706 rs233058 chr1:85798865 G/T cg16011679 chr1:85725395 C1orf52 0.48 5.68 0.33 3.58e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21227347 chr9:117374170 C9orf91 -0.43 -6.1 -0.35 3.82e-9 Gambling; CESC cis rs4148883 0.675 rs34511427 chr4:100105405 G/T cg13256891 chr4:100009986 ADH5 0.53 6.95 0.39 2.8e-11 Alcohol dependence; CESC cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg19912559 chr1:40204330 PPIE 0.41 6.19 0.36 2.22e-9 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02099053 chr1:110880516 RBM15 -0.57 -6.73 -0.38 1.05e-10 Gut microbiome composition (summer); CESC cis rs9660992 0.542 rs17345153 chr1:205179997 A/G cg00857998 chr1:205179979 DSTYK 0.56 7.12 0.4 1.02e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs9611565 0.729 rs2413646 chr22:41906325 C/T cg03806693 chr22:41940476 POLR3H -1.2 -14.88 -0.67 7.9e-37 Vitiligo; CESC cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg20307385 chr11:47447363 PSMC3 -0.52 -6.29 -0.36 1.32e-9 Subjective well-being; CESC cis rs7818688 0.697 rs11784140 chr8:95987480 G/T cg16049864 chr8:95962084 TP53INP1 0.55 5.6 0.33 5.32e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs6088580 0.634 rs6058041 chr20:33018008 A/G cg08999081 chr20:33150536 PIGU 0.65 11.48 0.58 4.87e-25 Glomerular filtration rate (creatinine); CESC cis rs2635047 0.935 rs2576031 chr18:44658146 A/G cg19077165 chr18:44547161 KATNAL2 -0.5 -6.9 -0.39 3.81e-11 Educational attainment; CESC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg07507251 chr3:52567010 NT5DC2 0.47 8.72 0.47 3.18e-16 Electroencephalogram traits; CESC cis rs3784262 1.000 rs3204689 chr15:58246802 G/C cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.32 -0.31 2.2e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs425277 0.917 rs78395918 chr1:2045876 G/A cg04315214 chr1:2043799 PRKCZ -0.43 -6.01 -0.35 6.26e-9 Height; CESC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg22535103 chr8:58192502 C8orf71 -1.02 -12.7 -0.62 3.45e-29 Developmental language disorder (linguistic errors); CESC trans rs11039798 0.920 rs11039940 chr11:48716316 C/T cg15704280 chr7:45808275 SEPT13 0.7 6.42 0.37 6.38e-10 Axial length; CESC trans rs10065369 0.545 rs11747036 chr5:113503402 A/T cg04850370 chr1:32573395 KPNA6 0.61 6.04 0.35 5.31e-9 Night sleep phenotypes; CESC trans rs11971186 0.824 rs1204516 chr7:126503252 A/C cg10894441 chr11:111169905 C11orf92;C11orf93 0.48 6.09 0.35 3.99e-9 Chemerin levels; CESC cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg02487422 chr3:49467188 NICN1 0.4 5.08 0.3 6.97e-7 Parkinson's disease; CESC trans rs11098499 0.909 rs79704848 chr4:120309351 T/A cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs317689 0.690 rs570256 chr12:69662929 A/T cg14784868 chr12:69753453 YEATS4 0.5 5.41 0.32 1.38e-7 Response to diuretic therapy; CESC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg08132940 chr7:1081526 C7orf50 -0.47 -5.05 -0.3 8.21e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs8073060 0.586 rs9303690 chr17:34005513 C/T cg19694781 chr19:47549865 TMEM160 -0.72 -6.82 -0.39 6.11e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs12824058 0.831 rs11616174 chr12:130814503 A/G cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs4803468 0.967 rs67047091 chr19:41938684 C/T cg14132834 chr19:41945861 ATP5SL 0.69 8.52 0.46 1.24e-15 Height; CESC cis rs977987 0.806 rs4887823 chr16:75433074 T/A cg03315344 chr16:75512273 CHST6 0.4 5.71 0.33 3e-8 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13866129 chr11:62623438 SNORD27;SLC3A2;SNORD28;SNORD25;SNORD26;SNHG1 0.57 6.93 0.39 3.19e-11 Gut microbiome composition (summer); CESC cis rs11148252 0.574 rs2038826 chr13:53280013 G/A cg00495681 chr13:53174319 NA 0.59 8.24 0.45 8.2e-15 Lewy body disease; CESC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg13798912 chr7:905769 UNC84A -0.56 -5.52 -0.32 8.27e-8 Cerebrospinal P-tau181p levels; CESC trans rs7937682 0.924 rs499750 chr11:111513645 T/G cg18187862 chr3:45730750 SACM1L 0.5 6.44 0.37 5.46e-10 Primary sclerosing cholangitis; CESC cis rs7772486 0.686 rs857883 chr6:145969214 G/T cg05347473 chr6:146136440 FBXO30 -0.55 -7.1 -0.4 1.12e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.98 -0.35 7.04e-9 Total body bone mineral density; CESC cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg11890956 chr21:40555474 PSMG1 1.13 20.04 0.78 5.19e-55 Cognitive function; CESC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8141529 0.687 rs6005867 chr22:29165120 T/C cg02153584 chr22:29168773 CCDC117 0.72 10.16 0.53 1.11e-20 Lymphocyte counts; CESC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -6.57 -0.37 2.71e-10 Developmental language disorder (linguistic errors); CESC cis rs1153858 1.000 rs1613559 chr15:45622116 A/G cg21132104 chr15:45694354 SPATA5L1 0.78 10.44 0.54 1.35e-21 Homoarginine levels; CESC cis rs6088580 0.634 rs4911151 chr20:32932273 T/C cg08999081 chr20:33150536 PIGU -0.64 -11.02 -0.56 1.76e-23 Glomerular filtration rate (creatinine); CESC cis rs7680126 0.596 rs11722185 chr4:10317482 C/G cg00071950 chr4:10020882 SLC2A9 -0.51 -5.74 -0.33 2.6e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg13147721 chr7:65941812 NA 0.37 5.13 0.3 5.57e-7 Aortic root size; CESC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.96 -0.34 8.05e-9 Cardiac Troponin-T levels; CESC cis rs13118159 0.641 rs4974598 chr4:1313220 C/T cg16405210 chr4:1374714 KIAA1530 -0.62 -8.36 -0.46 3.58e-15 Longevity; CESC cis rs1707322 1.000 rs946527 chr1:46485970 C/T cg03146154 chr1:46216737 IPP 0.71 9.76 0.51 2.08e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26737766 chr1:24127303 GALE -0.45 -6.21 -0.36 2.01e-9 Asthma; CESC cis rs965469 0.895 rs6051839 chr20:3391191 C/T cg25506879 chr20:3388711 C20orf194 0.58 6.17 0.35 2.56e-9 IFN-related cytopenia; CESC cis rs7917772 0.503 rs7915589 chr10:104299264 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.49 0.42 9.98e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs854765 0.647 rs854767 chr17:18018263 A/C cg04398451 chr17:18023971 MYO15A 0.76 11.35 0.57 1.31e-24 Total body bone mineral density; CESC cis rs7208859 0.623 rs7503335 chr17:29073962 G/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -0.79 -8.57 -0.47 8.91e-16 Alzheimer's disease; CESC trans rs11088226 0.645 rs78172258 chr21:33936539 T/G cg09050820 chr6:167586206 TCP10L2 0.83 7.75 0.43 2.01e-13 Gastritis; CESC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg07167872 chr1:205819463 PM20D1 0.77 12.56 0.61 1.05e-28 Menarche (age at onset); CESC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Parkinson's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03398387 chr6:160114178 SOD2 0.46 6.09 0.35 3.92e-9 Gut microbiota (bacterial taxa); CESC cis rs62064224 0.791 rs11653160 chr17:30717222 A/G cg18200150 chr17:30822561 MYO1D 0.68 10.48 0.54 9.68e-22 Schizophrenia; CESC cis rs6089584 0.566 rs6061963 chr20:60607480 C/G cg06108461 chr20:60628389 TAF4 -0.58 -7.67 -0.43 3.26e-13 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23504092 chr20:13201342 ISM1 0.5 6.17 0.35 2.55e-9 Gut microbiome composition (summer); CESC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg22433210 chr17:43662623 NA 0.99 11.0 0.56 1.96e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.59 0.38 2.35e-10 Bipolar disorder; CESC cis rs992157 0.710 rs10169718 chr2:219103580 C/T cg00012203 chr2:219082015 ARPC2 -0.85 -12.53 -0.61 1.3e-28 Colorectal cancer; CESC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg07677032 chr17:61819896 STRADA 0.41 5.17 0.3 4.59e-7 Height; CESC cis rs10832963 1.000 rs7943121 chr11:18656062 G/C cg09201001 chr11:18656081 SPTY2D1 0.82 12.42 0.61 3.32e-28 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15003434 chr9:136202985 SURF6 -0.45 -6.57 -0.37 2.72e-10 Fibrinogen levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04259979 chr5:44808944 MRPS30 0.49 6.1 0.35 3.7e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg18904891 chr8:8559673 CLDN23 0.68 7.92 0.44 6.49e-14 Obesity-related traits; CESC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg21017887 chr14:105400489 NA 0.41 6.67 0.38 1.45e-10 Rheumatoid arthritis; CESC cis rs2777491 0.915 rs16971767 chr15:41623308 T/C cg02330683 chr15:41787940 ITPKA 0.43 6.27 0.36 1.43e-9 Ulcerative colitis; CESC cis rs67460515 0.563 rs68166680 chr3:160829735 T/A cg03342759 chr3:160939853 NMD3 -0.54 -6.86 -0.39 4.9e-11 Parkinson's disease; CESC cis rs1003719 0.751 rs2835585 chr21:38460488 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.67 0.47 4.41e-16 Eye color traits; CESC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg04414720 chr1:150670196 GOLPH3L 0.61 8.64 0.47 5.42e-16 Tonsillectomy; CESC cis rs2952156 0.920 rs732084 chr17:37834357 A/C cg19468946 chr17:37922297 IKZF3 -0.39 -5.1 -0.3 6.37e-7 Asthma; CESC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.36 0.5 3.44e-18 Menopause (age at onset); CESC cis rs1577917 0.958 rs7747897 chr6:86647349 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.87 -0.34 1.31e-8 Response to antipsychotic treatment; CESC cis rs9611565 0.512 rs7291736 chr22:42124874 C/A cg06634786 chr22:41940651 POLR3H 0.65 6.57 0.37 2.6200000000000003e-10 Vitiligo; CESC cis rs748404 0.723 rs560134 chr15:43555699 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.61 8.03 0.44 3.2e-14 Lung cancer; CESC cis rs7666738 0.830 rs991169 chr4:98928567 C/A cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04276370 chr6:160390055 IGF2R 0.59 6.72 0.38 1.14e-10 Gut microbiome composition (summer); CESC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 10.61 0.55 3.86e-22 Platelet count; CESC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg22800045 chr5:56110881 MAP3K1 -0.59 -7.8 -0.43 1.43e-13 Initial pursuit acceleration; CESC cis rs2929278 0.589 rs7174732 chr15:44038463 C/A cg02155558 chr15:43621948 ADAL;LCMT2 -0.47 -7.42 -0.41 1.6e-12 Schizophrenia; CESC cis rs3106136 1.000 rs3106136 chr4:95153349 T/C cg11021082 chr4:95130006 SMARCAD1 -0.48 -7.41 -0.41 1.65e-12 Capecitabine sensitivity; CESC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg03188948 chr7:1209495 NA 0.73 7.02 0.4 1.85e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg09035930 chr12:129282057 SLC15A4 0.76 10.86 0.55 5.73e-23 Systemic lupus erythematosus; CESC cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg25019033 chr10:957182 NA -0.52 -5.56 -0.32 6.58e-8 Eosinophil percentage of granulocytes; CESC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg16405210 chr4:1374714 KIAA1530 -0.6 -8.29 -0.45 5.79e-15 Longevity; CESC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -8.18 -0.45 1.19e-14 Developmental language disorder (linguistic errors); CESC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Blood metabolite levels; CESC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg14703610 chr5:56206110 C5orf35 0.52 6.9 0.39 3.86e-11 Coronary artery disease; CESC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs6456156 0.586 rs720325 chr6:167467349 G/T cg07741184 chr6:167504864 NA 0.37 6.25 0.36 1.62e-9 Primary biliary cholangitis; CESC cis rs2120019 0.938 rs8040169 chr15:75370958 C/A cg09165964 chr15:75287851 SCAMP5 -0.67 -8.12 -0.45 1.76e-14 Blood trace element (Zn levels); CESC cis rs11098499 0.789 rs12498994 chr4:120250818 A/C cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs925228 0.504 rs7568272 chr2:24313785 T/C cg01493198 chr2:24299560 SF3B14 0.68 5.91 0.34 1.04e-8 Reticulocyte fraction of red cells;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07817097 chr1:179851575 TOR1AIP1 0.58 7.03 0.4 1.75e-11 Gut microbiome composition (summer); CESC cis rs2932538 0.922 rs6673930 chr1:113104887 A/G cg22162597 chr1:113214053 CAPZA1 0.54 6.94 0.39 2.97e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg03467027 chr4:99064603 C4orf37 0.42 5.17 0.3 4.66e-7 Colonoscopy-negative controls vs population controls; CESC cis rs5771242 0.518 rs6010216 chr22:50679471 C/T cg16473166 chr22:50639996 SELO 0.6 7.15 0.4 8.47e-12 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC cis rs425277 0.565 rs61775448 chr1:2045376 A/G cg23803603 chr1:2058230 PRKCZ -0.35 -6.12 -0.35 3.38e-9 Height; CESC cis rs2710642 0.962 rs7567923 chr2:63085848 C/T cg17519650 chr2:63277830 OTX1 -0.55 -7.28 -0.41 3.78e-12 LDL cholesterol levels;LDL cholesterol; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26335430 chr17:73780571 UNK 0.45 6.47 0.37 4.63e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs637571 0.522 rs1786175 chr11:65754808 G/A cg17712092 chr4:129076599 LARP1B 0.75 10.7 0.55 1.89e-22 Eosinophil percentage of white cells; CESC cis rs6121246 0.609 rs6060983 chr20:30420924 T/C cg13852791 chr20:30311386 BCL2L1 0.8 10.12 0.53 1.39e-20 Mean corpuscular hemoglobin; CESC cis rs11864453 1.000 rs7201491 chr16:72034312 G/A cg01557791 chr16:72042693 DHODH -0.67 -9.11 -0.49 2.07e-17 Fibrinogen levels; CESC cis rs7809950 1.000 rs2395883 chr7:107089670 T/C cg23024343 chr7:107201750 COG5 -0.41 -5.81 -0.34 1.75e-8 Coronary artery disease; CESC cis rs7191700 0.673 rs12325495 chr16:11418328 C/T cg00044050 chr16:11439710 C16orf75 0.46 5.71 0.33 3.07e-8 Multiple sclerosis; CESC cis rs9399135 0.967 rs12527707 chr6:135324511 G/A cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs6690583 0.623 rs74761855 chr1:85432947 A/C cg22153463 chr1:85462885 MCOLN2 0.78 7.42 0.41 1.57e-12 Serum sulfate level; CESC cis rs7267979 0.903 rs2474766 chr20:25246153 A/G cg08601574 chr20:25228251 PYGB 0.43 6.32 0.36 1.1e-9 Liver enzyme levels (alkaline phosphatase); CESC cis rs9296736 0.890 rs9382280 chr6:53912613 C/T cg04374786 chr6:53939321 C6orf142 0.35 5.31 0.31 2.38e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9457247 0.508 rs6941355 chr6:167506238 A/G cg23791538 chr6:167370224 RNASET2 -0.45 -5.77 -0.33 2.2e-8 Crohn's disease; CESC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg22029157 chr1:209979665 IRF6 0.67 7.21 0.41 5.69e-12 Cleft lip with or without cleft palate; CESC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg27170947 chr2:26402098 FAM59B -0.84 -9.99 -0.52 3.83e-20 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10165071 chr2:217557160 IGFBP5 -0.61 -7.56 -0.42 6.44e-13 Gut microbiome composition (summer); CESC trans rs11098499 0.954 rs12508504 chr4:120410607 A/C cg25214090 chr10:38739885 LOC399744 0.72 10.56 0.54 5.46e-22 Corneal astigmatism; CESC cis rs17376456 0.825 rs6898842 chr5:93213221 T/C cg21475434 chr5:93447410 FAM172A 0.83 7.21 0.41 5.8e-12 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09571404 chr2:241500448 DUSP28 0.62 6.98 0.39 2.32e-11 Gut microbiome composition (summer); CESC cis rs11098499 0.820 rs28535956 chr4:120536858 C/T cg24375607 chr4:120327624 NA -0.45 -5.59 -0.32 5.71e-8 Corneal astigmatism; CESC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.79 10.49 0.54 9.34e-22 Height; CESC cis rs9287719 0.967 rs7608498 chr2:10738428 G/A cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC trans rs9467711 0.659 rs35433030 chr6:26529890 G/A cg06606381 chr12:133084897 FBRSL1 -0.93 -7.16 -0.4 8.07e-12 Autism spectrum disorder or schizophrenia; CESC cis rs3820928 1.000 rs59904960 chr2:227761269 T/C cg11843606 chr2:227700838 RHBDD1 -0.44 -5.84 -0.34 1.52e-8 Pulmonary function; CESC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg07092213 chr7:1199455 ZFAND2A -0.48 -5.67 -0.33 3.71e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2115536 0.606 rs8024713 chr15:80206958 C/G cg02196730 chr15:80188777 MTHFS 0.45 5.74 0.33 2.58e-8 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC trans rs9929218 0.954 rs4485355 chr16:68754730 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -9.95 -0.52 5.04e-20 Colorectal cancer; CESC cis rs3820068 0.554 rs60233444 chr1:15921330 A/C cg17385448 chr1:15911702 AGMAT 0.42 6.72 0.38 1.13e-10 Systolic blood pressure; CESC cis rs6973256 0.568 rs7783019 chr7:133347347 A/G cg10665199 chr7:133106180 EXOC4 -0.46 -6.26 -0.36 1.55e-9 Intelligence (multi-trait analysis); CESC cis rs9633740 1.000 rs1902660 chr10:82263683 G/C cg00277334 chr10:82204260 NA -0.58 -5.83 -0.34 1.62e-8 Post bronchodilator FEV1; CESC cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg09060608 chr5:178986726 RUFY1 0.51 7.79 0.43 1.5700000000000001e-13 Lung cancer; CESC cis rs12824058 0.831 rs12320318 chr12:130812335 T/C cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19024381 chr2:242626441 DTYMK -0.57 -6.82 -0.39 6.3e-11 Ulcerative colitis; CESC cis rs9486719 1.000 rs67996804 chr6:96884387 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs950776 0.752 rs62010327 chr15:78892784 G/A cg06917634 chr15:78832804 PSMA4 0.63 7.42 0.41 1.6e-12 Sudden cardiac arrest; CESC cis rs5753618 0.554 rs5753648 chr22:31879465 A/G cg00478049 chr22:31556069 RNF185 -0.48 -5.44 -0.32 1.23e-7 Colorectal cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23469188 chr7:108166441 PNPLA8 -0.48 -6.32 -0.36 1.13e-9 Fibrinogen levels; CESC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg20295408 chr7:1910781 MAD1L1 -0.42 -5.4 -0.31 1.51e-7 Bipolar disorder and schizophrenia; CESC cis rs9300255 0.537 rs2682429 chr12:123642955 C/G cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.16e-16 Neutrophil percentage of white cells; CESC cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg11502198 chr6:26597334 ABT1 -0.5 -5.29 -0.31 2.61e-7 Intelligence (multi-trait analysis); CESC cis rs2652822 0.530 rs1017545 chr15:63553994 A/G cg02713581 chr15:63449717 RPS27L 0.41 5.07 0.3 7.51e-7 Metabolic traits; CESC cis rs4835473 0.864 rs7682096 chr4:144630045 A/T cg25736465 chr4:144833511 NA 0.4 6.17 0.35 2.59e-9 Immature fraction of reticulocytes; CESC cis rs28830936 1.000 rs12440747 chr15:42036690 G/A cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.37 -5.43 -0.32 1.25e-7 Diastolic blood pressure; CESC cis rs6540559 0.611 rs76766079 chr1:209997731 C/T cg22029157 chr1:209979665 IRF6 0.72 7.72 0.43 2.32e-13 Cleft lip with or without cleft palate; CESC cis rs7385804 0.633 rs221795 chr7:100283261 C/T cg16850897 chr7:100343110 ZAN 0.52 7.39 0.41 1.9e-12 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC trans rs877282 0.891 rs12767043 chr10:797943 C/T cg22713356 chr15:30763199 NA 1.35 13.42 0.64 1.08e-31 Uric acid levels; CESC cis rs2439831 1.000 rs2467743 chr15:43750346 T/A cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.57 0.54 5.08e-22 Lung cancer in ever smokers; CESC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg07092213 chr7:1199455 ZFAND2A -0.4 -5.45 -0.32 1.13e-7 Longevity;Endometriosis; CESC cis rs830124 0.602 rs1375655 chr12:122385690 A/G cg22168489 chr12:122356033 WDR66 0.38 5.12 0.3 5.85e-7 Urinary metabolites; CESC cis rs910316 1.000 rs12588240 chr14:75612083 C/A cg11812906 chr14:75593930 NEK9 0.91 15.77 0.7 5.67e-40 Height; CESC cis rs9486715 0.830 rs2475023 chr6:96996833 G/A cg18709589 chr6:96969512 KIAA0776 -0.46 -6.49 -0.37 4.3e-10 Headache; CESC cis rs73001065 0.591 rs11668386 chr19:19531910 A/G cg03709012 chr19:19516395 GATAD2A 0.92 7.09 0.4 1.19e-11 LDL cholesterol; CESC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.46 7.39 0.41 1.86e-12 Personality dimensions; CESC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg18402987 chr7:1209562 NA 0.74 8.07 0.44 2.5e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1008375 0.932 rs4698627 chr4:17605959 T/C cg16339924 chr4:17578868 LAP3 0.63 8.08 0.44 2.34e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.53 0.32 7.6e-8 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02671806 chr15:65477420 CLPX -0.43 -6.06 -0.35 4.53e-9 Gambling; CESC cis rs4728302 0.869 rs12707128 chr7:133589796 A/G cg10665199 chr7:133106180 EXOC4 0.4 5.41 0.32 1.44e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs2439831 1.000 rs690263 chr15:43704465 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.8 11.73 0.58 7.16e-26 Lung cancer in ever smokers; CESC cis rs13385 0.769 rs34675890 chr5:139622272 T/C cg26211634 chr5:139558579 C5orf32 0.49 5.32 0.31 2.2e-7 Atrial fibrillation; CESC cis rs7208859 0.562 rs216408 chr17:28907757 C/G cg19761014 chr17:28927070 LRRC37B2 -0.81 -7.73 -0.43 2.29e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10752881 0.935 rs12082051 chr1:183051614 C/T ch.1.3577855R chr1:183094577 LAMC1 0.85 13.7 0.64 1.21e-32 Colorectal cancer; CESC cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4077515 0.934 rs78428995 chr9:139281847 T/C cg14169450 chr9:139327907 INPP5E 0.39 5.59 0.32 5.58e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs2070488 0.775 rs1073505 chr3:38566722 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.78 -12.87 -0.62 9.13e-30 Electrocardiographic conduction measures; CESC cis rs7296418 0.816 rs1790096 chr12:123710364 C/T cg05973401 chr12:123451056 ABCB9 0.51 6.63 0.38 1.88e-10 Platelet count; CESC cis rs75064307 0.798 rs2290601 chr3:108112760 C/T cg03329597 chr3:108125523 MYH15 0.52 5.86 0.34 1.4e-8 Intelligence (multi-trait analysis); CESC cis rs1665050 0.534 rs4775106 chr15:59238261 A/G cg05156742 chr15:59063176 FAM63B 0.5 6.42 0.37 6.18e-10 Atopic dermatitis; CESC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -6.75 -0.38 9.12e-11 Personality dimensions; CESC trans rs6921919 0.562 rs13198809 chr6:28323702 G/A cg06606381 chr12:133084897 FBRSL1 -1.1 -8.38 -0.46 3.13e-15 Autism spectrum disorder or schizophrenia; CESC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg18099408 chr3:52552593 STAB1 -0.35 -6.11 -0.35 3.63e-9 Electroencephalogram traits; CESC cis rs739401 0.572 rs12276060 chr11:3015572 A/T cg25174290 chr11:3078921 CARS 0.51 6.94 0.39 3.06e-11 Longevity; CESC cis rs870825 0.698 rs72703549 chr4:185623963 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs863345 0.604 rs7544134 chr1:158475421 G/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.58e-11 Pneumococcal bacteremia; CESC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg16325326 chr1:53192061 ZYG11B 0.53 7.5 0.42 9.67e-13 Monocyte count; CESC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.67 -8.57 -0.47 8.66e-16 Mean platelet volume; CESC cis rs6500395 1.000 rs7194570 chr16:48672986 A/G cg04672837 chr16:48644449 N4BP1 -0.49 -6.14 -0.35 2.97e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg17158414 chr2:27665306 KRTCAP3 -0.29 -5.34 -0.31 2.04e-7 Total body bone mineral density; CESC cis rs2267137 0.868 rs5763178 chr22:29773869 A/G cg07256473 chr22:29710276 RASL10A 0.41 6.16 0.35 2.76e-9 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs2180341 0.920 rs9398836 chr6:127576497 T/G cg24812749 chr6:127587940 RNF146 1.08 15.45 0.69 7.93e-39 Breast cancer; CESC cis rs35955747 1.000 rs35955747 chr22:31813058 A/T cg25791279 chr22:32026902 PISD -0.43 -5.13 -0.3 5.7e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs8114671 0.562 rs6058137 chr20:33475074 G/A cg07148914 chr20:33460835 GGT7 0.52 6.78 0.38 7.94e-11 Height; CESC cis rs9660992 0.789 rs1768584 chr1:205240145 A/G cg21643547 chr1:205240462 TMCC2 -0.47 -6.93 -0.39 3.13e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs11264213 0.786 rs72659686 chr1:36275767 G/T cg27506609 chr1:36549197 TEKT2 0.65 5.34 0.31 1.97e-7 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24333206 chr3:140660642 SLC25A36 -0.45 -6.11 -0.35 3.54e-9 Gut microbiota (bacterial taxa); CESC cis rs11723261 0.621 rs57013142 chr4:135738 T/A cg12746427 chr4:53362 ZNF718;ZNF595 0.43 5.08 0.3 7.2e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs2502731 0.539 rs3003615 chr9:130997892 C/T cg09976142 chr9:130955436 CIZ1 0.39 6.29 0.36 1.33e-9 Attention deficit hyperactivity disorder; CESC cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.9 0.34 1.11e-8 Colonoscopy-negative controls vs population controls; CESC cis rs752010 0.875 rs11210502 chr1:42093712 A/C cg06885757 chr1:42089581 HIVEP3 0.53 8.91 0.48 8.68e-17 Lupus nephritis in systemic lupus erythematosus; CESC cis rs71636778 0.509 rs71636795 chr1:27241025 A/G cg12203394 chr1:27248618 NUDC 0.66 5.55 0.32 6.85e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs2425143 0.514 rs8114246 chr20:34581979 T/G cg23207816 chr20:34252616 CPNE1;RBM12 0.52 5.05 0.3 8.09e-7 Blood protein levels; CESC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg22535103 chr8:58192502 C8orf71 -0.92 -10.22 -0.53 6.79e-21 Developmental language disorder (linguistic errors); CESC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg24308560 chr3:49941425 MST1R -0.64 -9.19 -0.49 1.17e-17 Intelligence (multi-trait analysis); CESC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg09365446 chr1:150670422 GOLPH3L 0.4 5.68 0.33 3.53e-8 Tonsillectomy; CESC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg02187348 chr16:89574699 SPG7 0.56 7.73 0.43 2.25e-13 Multiple myeloma (IgH translocation); CESC cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg06873352 chr17:61820015 STRADA 0.49 7.31 0.41 3.09e-12 Height; CESC trans rs16845107 0.826 rs16861032 chr3:113187675 C/G cg14157042 chr20:58515396 C20orf177;PPP1R3D -0.84 -6.08 -0.35 4.27e-9 Colorectal cancer; CESC cis rs826838 1.000 rs851934 chr12:39104453 G/T cg26384229 chr12:38710491 ALG10B -0.63 -9.99 -0.52 3.63e-20 Heart rate; CESC cis rs524281 0.684 rs7946447 chr11:65864338 T/C cg14036092 chr11:66035641 RAB1B -0.56 -5.92 -0.34 1.01e-8 Electroencephalogram traits; CESC cis rs7818688 0.697 rs11780130 chr8:95976083 A/G cg16049864 chr8:95962084 TP53INP1 0.57 5.73 0.33 2.79e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs11583043 0.918 rs11581062 chr1:101407519 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.44 -5.08 -0.3 7.1e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs2046867 0.818 rs2208 chr3:72871773 A/G cg25664220 chr3:72788482 NA 0.43 6.27 0.36 1.46e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs4481887 0.893 rs1339991 chr1:248509363 C/T cg00666640 chr1:248458726 OR2T12 0.35 6.02 0.35 5.85e-9 Common traits (Other); CESC cis rs713587 0.520 rs488817 chr2:25332696 C/T cg01884057 chr2:25150051 NA -0.3 -5.17 -0.3 4.65e-7 Body mass index in non-asthmatics; CESC cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg06027949 chr8:82754900 SNX16 -0.41 -5.03 -0.3 8.94e-7 Diastolic blood pressure; CESC cis rs9814567 0.929 rs2241556 chr3:134183312 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.37 5.15 0.3 5.14e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4803468 0.934 rs2317131 chr19:41885151 C/T cg09537434 chr19:41945824 ATP5SL -1.02 -18.01 -0.74 6.8e-48 Height; CESC cis rs9611565 0.765 rs132915 chr22:41805782 T/C cg03806693 chr22:41940476 POLR3H 1.04 12.37 0.61 4.76e-28 Vitiligo; CESC cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.96 -0.34 8.13e-9 Total body bone mineral density; CESC cis rs7267979 1.000 rs4815421 chr20:25386509 G/A cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.85e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs12681287 0.517 rs68008113 chr8:87520894 C/A cg27317242 chr8:23145699 R3HCC1 -0.51 -6.08 -0.35 4.09e-9 Caudate activity during reward; CESC cis rs7264396 0.790 rs11697903 chr20:34272224 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.81 0.43 1.36e-13 Total cholesterol levels; CESC cis rs3857536 0.813 rs6455083 chr6:66935406 T/C cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs8017423 0.935 rs2104704 chr14:90696609 A/G cg14092571 chr14:90743983 NA 0.54 7.9 0.44 7.42e-14 Mortality in heart failure; CESC trans rs875971 0.964 rs6945019 chr7:65922458 C/G cg26939375 chr7:64535504 NA 0.47 6.07 0.35 4.41e-9 Aortic root size; CESC cis rs66887589 0.967 rs1155577 chr4:120449810 C/T cg09307838 chr4:120376055 NA -0.51 -6.94 -0.39 3.03e-11 Diastolic blood pressure; CESC cis rs8070740 0.838 rs1050456 chr17:5336188 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.58 6.7 0.38 1.27e-10 Menopause (age at onset); CESC cis rs10911251 0.508 rs2296297 chr1:183105324 C/T ch.1.3577855R chr1:183094577 LAMC1 0.85 13.35 0.63 1.89e-31 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20227886 chr18:48405353 ME2 0.62 7.14 0.4 8.8e-12 Gut microbiome composition (summer); CESC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg00769240 chr8:12517080 NA -0.44 -6.02 -0.35 5.7e-9 Blood pressure (smoking interaction); CESC trans rs7980799 0.935 rs4931717 chr12:33521151 A/G cg26384229 chr12:38710491 ALG10B 0.52 7.23 0.41 5.14e-12 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs62432291 0.614 rs420339 chr6:159657195 G/T cg14500486 chr6:159655392 FNDC1 -0.62 -6.34 -0.36 9.83e-10 Joint mobility (Beighton score); CESC cis rs9902453 0.967 rs4294864 chr17:28440138 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 7.99 0.44 4.2e-14 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14851770 chr14:50065970 PPIL5 0.6 6.89 0.39 4.05e-11 Gut microbiome composition (summer); CESC cis rs3096299 0.781 rs2965819 chr16:89501030 G/T cg00750074 chr16:89608354 SPG7 0.39 5.64 0.33 4.31e-8 Multiple myeloma (IgH translocation); CESC cis rs25645 0.744 rs66826786 chr17:38206092 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.55 7.58 0.42 5.86e-13 Myeloid white cell count; CESC cis rs7267979 1.000 rs2500436 chr20:25406366 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.42 -0.71 2.87e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs3960554 0.709 rs73138006 chr7:75769990 T/C cg17325771 chr7:75508891 RHBDD2 -0.35 -5.21 -0.3 3.82e-7 Eotaxin levels; CESC cis rs9329289 0.510 rs11251283 chr10:2555784 C/G cg15501526 chr10:2543763 NA 0.47 7.39 0.41 1.92e-12 Age-related hearing impairment; CESC cis rs763014 0.931 rs3752567 chr16:628130 A/G cg07343612 chr16:622815 PIGQ -0.58 -8.36 -0.46 3.61e-15 Height; CESC cis rs8053891 0.502 rs34679758 chr16:71995427 A/G cg04254540 chr16:71951199 KIAA0174 -0.88 -8.04 -0.44 2.94e-14 Coronary artery disease; CESC cis rs796364 0.806 rs11691873 chr2:200966337 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.74 -6.39 -0.37 7.31e-10 Schizophrenia; CESC cis rs6964587 0.967 rs10953063 chr7:91576958 A/G cg17063962 chr7:91808500 NA -0.57 -7.68 -0.43 3.06e-13 Breast cancer; CESC cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.95 8.9 0.48 8.88e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1018836 0.786 rs10956736 chr8:91602067 C/T cg16814680 chr8:91681699 NA -0.72 -10.75 -0.55 1.31e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.43 5.82 0.34 1.68e-8 Lymphocyte counts; CESC cis rs782590 0.902 rs782600 chr2:55848040 T/C cg18811423 chr2:55921094 PNPT1 0.79 12.15 0.6 2.79e-27 Metabolic syndrome; CESC cis rs2832191 0.740 rs13048618 chr21:30458684 A/G cg08807101 chr21:30365312 RNF160 0.94 14.38 0.66 4.69e-35 Dental caries; CESC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg16132339 chr22:24313637 DDTL;DDT 0.37 5.55 0.32 7.05e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6736093 0.769 rs56361454 chr2:112774105 C/T cg07905836 chr2:113190072 RGPD8;RGPD5 -0.45 -5.2 -0.3 3.92e-7 Coronary artery disease; CESC cis rs360798 0.512 rs17027429 chr2:63079983 C/T cg17519650 chr2:63277830 OTX1 0.51 6.65 0.38 1.64e-10 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09527731 chr5:132097228 SEPT8 0.47 6.65 0.38 1.67e-10 Fibrinogen levels; CESC cis rs9303280 0.806 rs35736272 chr17:38032680 T/C cg19468946 chr17:37922297 IKZF3 -0.41 -5.49 -0.32 9.59e-8 Self-reported allergy; CESC cis rs10465746 0.780 rs10874423 chr1:84374071 C/T cg10977910 chr1:84465055 TTLL7 0.51 7.01 0.4 2.02e-11 Obesity-related traits; CESC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg20887711 chr4:1340912 KIAA1530 0.6 8.34 0.46 4.03e-15 Longevity; CESC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg00166722 chr3:10149974 C3orf24 0.51 6.06 0.35 4.6e-9 Alzheimer's disease; CESC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg18876405 chr7:65276391 NA -0.55 -7.15 -0.4 8.45e-12 Aortic root size; CESC cis rs2477686 0.526 rs12042427 chr1:2398107 C/T cg02275930 chr1:2372054 NA -0.53 -8.5 -0.46 1.44e-15 Non-obstructive azoospermia; CESC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg14829155 chr15:31115871 NA 0.76 10.65 0.55 2.8e-22 Huntington's disease progression; CESC cis rs2011503 0.941 rs11670775 chr19:19649636 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.5 5.05 0.3 8.31e-7 Bipolar disorder; CESC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg08392591 chr16:89556376 ANKRD11 0.61 8.31 0.45 5.13e-15 Multiple myeloma (IgH translocation); CESC cis rs2235642 0.750 rs2859310 chr16:1656765 C/T cg03771183 chr16:1608904 IFT140 -0.39 -5.63 -0.33 4.55e-8 Coronary artery disease; CESC cis rs6980507 0.524 rs4568607 chr8:42364354 T/C cg09913449 chr8:42400586 C8orf40 -0.36 -5.66 -0.33 3.98e-8 Glycated hemoglobin levels; CESC cis rs3768617 0.510 rs3768619 chr1:183092404 C/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07050647 chr2:122287957 CLASP1;RNU4ATAC 0.58 6.5 0.37 4.08e-10 Gut microbiome composition (summer); CESC cis rs1832871 0.672 rs56075516 chr6:158745752 G/A cg07165851 chr6:158734300 TULP4 0.59 6.41 0.37 6.63e-10 Height; CESC cis rs7216064 0.734 rs12942774 chr17:65967562 A/G cg07042672 chr17:66097459 LOC651250 0.5 6.95 0.39 2.92e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2243480 1.000 rs160637 chr7:65584318 C/T cg12463550 chr7:65579703 CRCP 0.74 5.77 0.33 2.23e-8 Diabetic kidney disease; CESC cis rs854765 0.547 rs2955372 chr17:17970229 T/C cg04398451 chr17:18023971 MYO15A 0.73 10.47 0.54 1.1e-21 Total body bone mineral density; CESC cis rs7124681 0.584 rs10769285 chr11:47709212 C/T cg20307385 chr11:47447363 PSMC3 0.61 8.46 0.46 1.87e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs11638352 1.000 rs2412850 chr15:44278161 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.53 -5.46 -0.32 1.09e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs9815354 0.767 rs73079325 chr3:41864565 G/A cg03022575 chr3:42003672 ULK4 0.49 5.52 0.32 7.99e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs2573652 1.000 rs2581362 chr15:100513524 T/C cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.45 -0.32 1.13e-7 Height; CESC cis rs1050631 0.564 rs1785929 chr18:33725165 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.05 0.44 2.82e-14 Esophageal squamous cell cancer (length of survival); CESC cis rs7631605 0.647 rs59594366 chr3:37173774 A/C cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.23 -0.31 3.44e-7 Cerebrospinal P-tau181p levels; CESC cis rs4718428 0.705 rs12698547 chr7:66278258 T/C cg12165864 chr7:66369176 NA -0.62 -6.97 -0.39 2.47e-11 Corneal structure; CESC cis rs7647973 0.696 rs7100 chr3:49053219 A/G cg07636037 chr3:49044803 WDR6 0.85 11.19 0.57 4.69e-24 Menarche (age at onset); CESC cis rs12042107 0.818 rs12568187 chr1:91193691 T/C cg13456504 chr1:91191583 NA 0.37 6.42 0.37 6.31e-10 Educational attainment; CESC cis rs9814567 1.000 rs7356093 chr3:134238753 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.44 -0.37 5.64e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs17253792 0.822 rs79398217 chr14:56067350 C/T cg01858014 chr14:56050164 KTN1 -0.95 -7.43 -0.42 1.54e-12 Putamen volume; CESC cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg22875332 chr1:76189707 ACADM 0.59 5.73 0.33 2.74e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11122272 0.525 rs2749713 chr1:231537921 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.48 -0.42 1.11e-12 Hemoglobin concentration; CESC cis rs9300255 0.568 rs1727300 chr12:123664205 C/T cg05973401 chr12:123451056 ABCB9 0.5 5.74 0.33 2.53e-8 Neutrophil percentage of white cells; CESC cis rs7666738 0.830 rs60007031 chr4:98824753 G/C cg05340658 chr4:99064831 C4orf37 0.73 10.47 0.54 1.07e-21 Colonoscopy-negative controls vs population controls; CESC cis rs9430161 0.611 rs2095920 chr1:11033457 T/A cg02454025 chr1:11042201 C1orf127 0.99 16.1 0.7 3.84e-41 Ewing sarcoma; CESC cis rs763121 0.853 rs4821798 chr22:39021165 T/C cg06022373 chr22:39101656 GTPBP1 0.96 17.24 0.73 3.58e-45 Menopause (age at onset); CESC cis rs2742234 0.541 rs2742235 chr10:43616325 A/G cg15436174 chr10:43711423 RASGEF1A -0.46 -5.38 -0.31 1.6e-7 Hirschsprung disease; CESC cis rs826838 0.967 rs1684415 chr12:39130099 T/C cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg15112475 chr7:1198522 ZFAND2A -0.39 -6.11 -0.35 3.53e-9 Longevity;Endometriosis; CESC cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg09988129 chr7:74988866 PMS2L2;STAG3L1 0.57 8.11 0.45 1.87e-14 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg02551604 chr5:131831745 NA 0.42 5.99 0.35 6.98e-9 Asthma (sex interaction); CESC cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg18512352 chr11:47633146 NA -0.6 -9.23 -0.49 8.67e-18 Subjective well-being; CESC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg08888203 chr3:10149979 C3orf24 0.46 6.01 0.35 6.24e-9 Alzheimer's disease; CESC cis rs11098499 0.909 rs2127821 chr4:120394535 T/C cg24375607 chr4:120327624 NA 0.45 5.72 0.33 2.9e-8 Corneal astigmatism; CESC cis rs7666738 0.830 rs7680909 chr4:98934604 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4072980 0.524 rs28477803 chr1:38398694 C/T cg04673462 chr1:38461896 NA 0.37 5.32 0.31 2.19e-7 Coronary artery disease; CESC cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg16339924 chr4:17578868 LAP3 0.59 7.4 0.41 1.83e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10979 1.000 rs12191231 chr6:143891114 A/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15422050 chr6:88412138 NCRNA00120;AKIRIN2 -0.49 -6.37 -0.36 8.24e-10 Fibrinogen levels; CESC cis rs28374715 0.532 rs28477406 chr15:41642036 C/G cg18705301 chr15:41695430 NDUFAF1 -1.07 -16.73 -0.72 2.18e-43 Ulcerative colitis; CESC cis rs72945132 0.882 rs4261311 chr11:70132902 C/T cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs7582720 1.000 rs114527590 chr2:203787405 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs4969178 0.965 rs11077364 chr17:76400337 C/A cg20026190 chr17:76395443 PGS1 0.46 7.35 0.41 2.41e-12 HDL cholesterol levels; CESC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg04772025 chr11:68637568 NA 0.5 6.07 0.35 4.44e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 7.5 0.42 9.57e-13 Total body bone mineral density; CESC trans rs629535 0.862 rs2178955 chr8:70045303 C/T cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs11031096 0.655 rs10835695 chr11:4178962 G/T cg18678763 chr11:4115507 RRM1 -0.43 -5.95 -0.34 8.38e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs3768617 0.624 rs34105373 chr1:183098387 T/C ch.1.3577855R chr1:183094577 LAMC1 0.65 9.12 0.49 1.89e-17 Fuchs's corneal dystrophy; CESC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC trans rs3942852 0.806 rs4752893 chr11:48118604 C/T cg15704280 chr7:45808275 SEPT13 -0.63 -7.45 -0.42 1.3e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs1461503 0.966 rs11218907 chr11:122841562 A/G cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs1878931 0.696 rs35984213 chr16:3451030 G/A cg00484396 chr16:3507460 NAT15 -0.39 -6.03 -0.35 5.63e-9 Body mass index (adult); CESC cis rs7615952 0.932 rs13086087 chr3:125646281 A/C cg05084668 chr3:125655381 ALG1L -0.51 -5.94 -0.34 8.98e-9 Blood pressure (smoking interaction); CESC cis rs727505 0.754 rs55723877 chr7:124780899 T/A cg23710748 chr7:124431027 NA -0.38 -6.2 -0.36 2.14e-9 Lewy body disease; CESC cis rs1775715 0.678 rs7096139 chr10:32217404 A/C cg18675610 chr10:32216311 ARHGAP12 0.36 5.51 0.32 8.56e-8 Bipolar disorder with mood-incongruent psychosis; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg06634887 chr4:967541 DGKQ 0.49 6.47 0.37 4.6e-10 Bronchopulmonary dysplasia; CESC cis rs9487051 0.714 rs7757347 chr6:109633815 G/A cg21918786 chr6:109611834 NA -0.39 -5.62 -0.33 4.72e-8 Reticulocyte fraction of red cells; CESC cis rs3003334 1 rs3003334 chr1:24199869 G/A cg10978503 chr1:24200527 CNR2 0.33 6.52 0.37 3.61e-10 Eosinophil percentage of white cells;Eosinophil percentage of granulocytes; CESC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.47 0.77 5.16e-53 Height; CESC trans rs9388451 0.626 rs1268074 chr6:126107791 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.56 -7.28 -0.41 3.8e-12 Brugada syndrome; CESC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg16680214 chr1:154839983 KCNN3 0.45 6.79 0.39 7.29e-11 Prostate cancer; CESC cis rs6087990 0.735 rs1003522 chr20:31368560 T/C cg13636640 chr20:31349939 DNMT3B 0.77 12.54 0.61 1.27e-28 Ulcerative colitis; CESC cis rs11650494 0.710 rs57030023 chr17:47468546 T/A cg08112188 chr17:47440006 ZNF652 0.84 6.39 0.37 7.58e-10 Prostate cancer; CESC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg18446336 chr7:2847575 GNA12 -0.39 -5.84 -0.34 1.49e-8 Height; CESC cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg27297192 chr10:134578999 INPP5A 0.4 5.46 0.32 1.08e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1506636 1.000 rs666266 chr7:123417759 A/G cg03229431 chr7:123269106 ASB15 0.49 6.59 0.38 2.41e-10 Plateletcrit;Platelet count; CESC trans rs61931739 0.534 rs4931783 chr12:34115322 G/A cg26384229 chr12:38710491 ALG10B 0.6 8.41 0.46 2.52e-15 Morning vs. evening chronotype; CESC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg08888203 chr3:10149979 C3orf24 0.48 6.06 0.35 4.71e-9 Alzheimer's disease; CESC cis rs17253792 0.915 rs28537145 chr14:56179119 G/A cg01858014 chr14:56050164 KTN1 -0.91 -7.03 -0.4 1.8e-11 Putamen volume; CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg10150615 chr22:24372951 LOC391322 0.56 7.51 0.42 8.92e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9914988 0.887 rs8078402 chr17:27145124 T/A cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs6736093 0.966 rs3761699 chr2:112705290 G/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.46 -0.32 1.1e-7 Coronary artery disease; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg15741583 chr11:6461908 HPX -0.35 -6.15 -0.35 2.91e-9 Breast cancer;Type 2 diabetes; CESC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.91e-8 Lung cancer; CESC cis rs684232 0.602 rs384628 chr17:554912 G/A cg12384639 chr17:618140 VPS53 0.41 5.31 0.31 2.36e-7 Prostate cancer; CESC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg05863683 chr7:1912471 MAD1L1 0.37 5.5 0.32 8.93e-8 Bipolar disorder and schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12468273 chr17:46620917 HOXB2 -0.45 -6.27 -0.36 1.45e-9 Fibrinogen levels; CESC cis rs11190604 0.943 rs9420792 chr10:102258439 C/T cg07080220 chr10:102295463 HIF1AN 0.68 6.68 0.38 1.42e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg11890956 chr21:40555474 PSMG1 -0.69 -9.97 -0.52 4.48e-20 Menarche (age at onset); CESC cis rs7095944 0.613 rs11245366 chr10:126482849 C/T cg08799069 chr10:126477246 METTL10 -0.4 -5.63 -0.33 4.52e-8 Asthma; CESC cis rs78456975 0.943 rs13391932 chr2:1577679 T/C cg26248373 chr2:1572462 NA -0.52 -5.11 -0.3 6.08e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12325245 0.536 rs12924708 chr16:58567643 G/A cg05725404 chr16:58534157 NDRG4 -0.61 -5.24 -0.31 3.21e-7 Schizophrenia; CESC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg12463550 chr7:65579703 CRCP 0.49 6.15 0.35 2.86e-9 Aortic root size; CESC cis rs138341189 1 rs138341189 chr11:68224411 GATTGTGCCAAT/G cg20283391 chr11:68216788 NA -0.66 -5.76 -0.33 2.35e-8 Monobrow; CESC cis rs1878931 0.726 rs3843728 chr16:3448251 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 1.11 19.51 0.77 3.49e-53 Body mass index (adult); CESC cis rs3096299 0.719 rs2965818 chr16:89510494 A/G cg08392591 chr16:89556376 ANKRD11 0.57 7.8 0.43 1.44e-13 Multiple myeloma (IgH translocation); CESC cis rs2074585 0.708 rs2601190 chr15:90932966 A/C cg22089800 chr15:90895588 ZNF774 0.67 9.33 0.5 4.5e-18 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs12220238 0.908 rs73284278 chr10:76011751 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.63 5.75 0.33 2.5e-8 Soluble interleukin-2 receptor subunit alpha; CESC cis rs8180040 0.701 rs34103310 chr3:47073266 C/T cg27129171 chr3:47204927 SETD2 0.69 10.35 0.54 2.56e-21 Colorectal cancer; CESC cis rs3820068 0.655 rs72645823 chr1:15887442 C/T cg17385448 chr1:15911702 AGMAT 0.37 5.81 0.34 1.8e-8 Systolic blood pressure; CESC cis rs6728642 0.908 rs13400545 chr2:97871626 A/G cg26665480 chr2:98280029 ACTR1B -0.86 -7.51 -0.42 9.04e-13 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg09359103 chr1:154839909 KCNN3 -0.64 -11.39 -0.57 9.95e-25 Prostate cancer; CESC cis rs9359856 0.564 rs17292768 chr6:90379311 T/C cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.38 -0.36 7.94e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13790909 chr19:36391442 NFKBID 0.58 6.77 0.38 8.39e-11 Gut microbiome composition (summer); CESC cis rs2075671 0.857 rs11772849 chr7:100308412 G/A cg16850897 chr7:100343110 ZAN -0.66 -8.3 -0.45 5.29e-15 Other erythrocyte phenotypes; CESC trans rs948562 0.690 rs11229425 chr11:58178587 C/T cg24637035 chr12:120445227 CCDC64 0.49 6.06 0.35 4.73e-9 Lymphoma; CESC cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4595586 0.525 rs4768531 chr12:39417754 T/A cg26384229 chr12:38710491 ALG10B 0.59 7.99 0.44 4.26e-14 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01811378 chr1:120611586 NOTCH2 0.66 7.97 0.44 4.81e-14 Gut microbiome composition (summer); CESC cis rs9902453 0.845 rs7221516 chr17:28232506 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.87 0.48 1.08e-16 Coffee consumption (cups per day); CESC cis rs7086627 0.515 rs7077373 chr10:82211615 C/T cg03267442 chr10:82210566 NA -0.34 -5.66 -0.33 3.98e-8 Post bronchodilator FEV1; CESC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg18876405 chr7:65276391 NA 0.52 7.03 0.4 1.8e-11 Aortic root size; CESC cis rs9611565 0.649 rs202614 chr22:41822150 A/C cg06481639 chr22:41940642 POLR3H 0.64 6.41 0.37 6.73e-10 Vitiligo; CESC cis rs9457247 0.534 rs9355610 chr6:167383075 G/A cg23791538 chr6:167370224 RNASET2 0.66 9.43 0.5 2.19e-18 Crohn's disease; CESC cis rs12765878 1.000 rs7100920 chr10:105640978 A/G cg11005552 chr10:105648138 OBFC1 -0.36 -5.21 -0.3 3.76e-7 Coronary artery disease; CESC cis rs113835537 0.529 rs2276406 chr11:66283257 C/T cg22134325 chr11:66188745 NPAS4 0.37 5.81 0.34 1.77e-8 Airway imaging phenotypes; CESC trans rs1493916 0.655 rs4534926 chr18:31349072 G/C cg27147174 chr7:100797783 AP1S1 -0.47 -6.15 -0.35 2.9e-9 Life satisfaction; CESC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg05863683 chr7:1912471 MAD1L1 0.37 5.42 0.32 1.35e-7 Bipolar disorder and schizophrenia; CESC cis rs4891159 0.527 rs34956524 chr18:74130480 A/G cg24786174 chr18:74118243 ZNF516 0.83 15.82 0.7 3.9e-40 Longevity; CESC cis rs6484504 0.576 rs208071 chr11:31144996 C/T cg14844989 chr11:31128820 NA -0.4 -5.68 -0.33 3.62e-8 Red blood cell count; CESC cis rs2249694 0.919 rs11101867 chr10:135400250 C/T cg20169779 chr10:135381914 SYCE1 -0.38 -5.48 -0.32 9.69e-8 Obesity-related traits; CESC cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg26597838 chr10:835615 NA 0.76 7.38 0.41 2.08e-12 Eosinophil percentage of granulocytes; CESC cis rs2243480 1.000 rs56016656 chr7:65383481 C/T cg18252515 chr7:66147081 NA -1.18 -10.88 -0.56 5.02e-23 Diabetic kidney disease; CESC cis rs1580019 0.922 rs34545272 chr7:32460630 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.81 11.17 0.57 5.36e-24 Cognitive ability; CESC cis rs4727027 0.804 rs13231262 chr7:148886058 C/T cg23158103 chr7:148848205 ZNF398 -0.4 -6.19 -0.36 2.26e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs15676 0.947 rs2977999 chr9:131579807 G/A cg00228799 chr9:131580591 ENDOG 0.44 5.47 0.32 1.06e-7 Blood metabolite levels; CESC cis rs4629710 0.563 rs9483238 chr6:131567196 A/T cg12606694 chr6:131520996 AKAP7 0.48 5.95 0.34 8.26e-9 Multiple myeloma (IgH translocation); CESC cis rs2302729 0.860 rs7138079 chr12:2781304 G/A cg19945202 chr12:2788847 CACNA1C -0.42 -5.47 -0.32 1.02e-7 Sleep quality; CESC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.57 0.32 6.16e-8 Menopause (age at onset); CESC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg03452623 chr4:187889614 NA -0.88 -16.15 -0.7 2.59e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.47 0.5 1.6e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10870270 0.956 rs11146425 chr10:133734261 C/T cg17892150 chr10:133769511 PPP2R2D -0.86 -12.69 -0.61 3.83e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs13253111 0.624 rs7012030 chr8:28096346 C/T cg26534493 chr8:28060551 NA 0.48 7.52 0.42 8.73e-13 Childhood body mass index; CESC cis rs8017423 0.874 rs4900029 chr14:90686257 T/A cg14092571 chr14:90743983 NA -0.57 -8.5 -0.46 1.4e-15 Mortality in heart failure; CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg18765753 chr7:1198926 ZFAND2A -0.5 -7.43 -0.42 1.47e-12 Longevity;Endometriosis; CESC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg15595755 chr5:1867978 NA 0.52 8.55 0.47 9.75e-16 Cardiovascular disease risk factors; CESC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.42e-7 Lung cancer; CESC cis rs933688 0.938 rs10942634 chr5:90658392 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 12.49 0.61 1.78e-28 Smoking behavior; CESC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg22029157 chr1:209979665 IRF6 0.77 8.93 0.48 7.41e-17 Cleft lip with or without cleft palate; CESC cis rs1018836 0.859 rs10808614 chr8:91569677 C/G cg16814680 chr8:91681699 NA -0.63 -9.25 -0.49 7.74e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg24562669 chr7:97807699 LMTK2 0.47 6.72 0.38 1.08e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs17508449 0.736 rs76038270 chr1:114238920 C/G cg23028848 chr11:57092561 TNKS1BP1 -0.79 -6.23 -0.36 1.86e-9 Leprosy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12566780 chr7:92157604 PEX1;C7orf64 -0.43 -6.08 -0.35 4.23e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs35146811 0.586 rs10267212 chr7:99595422 T/C cg22906224 chr7:99728672 NA 0.45 5.36 0.31 1.79e-7 Coronary artery disease; CESC cis rs910316 0.692 rs7156586 chr14:75506230 A/T cg08847533 chr14:75593920 NEK9 0.77 11.17 0.57 5.38e-24 Height; CESC cis rs4604732 0.631 rs12031694 chr1:247623653 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.46 6.08 0.35 4.15e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.68 0.47 4.11e-16 Menopause (age at onset); CESC cis rs8067354 0.681 rs9907923 chr17:57824927 C/T cg13753209 chr17:57696993 CLTC 0.65 7.95 0.44 5.28e-14 Hemoglobin concentration; CESC cis rs7481584 1.000 rs4758623 chr11:3014953 T/C cg25174290 chr11:3078921 CARS -0.45 -5.61 -0.33 4.97e-8 Calcium levels; CESC cis rs300703 0.604 rs373375 chr2:203350 C/A cg21211680 chr2:198530 NA 0.95 10.44 0.54 1.33e-21 Blood protein levels; CESC cis rs7267979 1.000 rs6050602 chr20:25401203 A/G cg08601574 chr20:25228251 PYGB -0.37 -5.36 -0.31 1.77e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg04287289 chr16:89883240 FANCA 0.63 8.77 0.47 2.22e-16 Vitiligo; CESC cis rs6502050 0.835 rs34199331 chr17:80134487 C/T cg11859384 chr17:80120422 CCDC57 -0.41 -5.71 -0.33 3.06e-8 Life satisfaction; CESC cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg24920358 chr1:40204285 PPIE 0.43 6.4 0.37 7.07e-10 Blood protein levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg18827097 chr2:3522506 ADI1 -0.46 -6.18 -0.35 2.47e-9 Height; CESC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg04234412 chr22:24373322 LOC391322 -0.53 -7.54 -0.42 7.35e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2455799 0.613 rs11713820 chr3:15866590 A/G cg16303742 chr3:15540471 COLQ 0.35 5.39 0.31 1.53e-7 Mean platelet volume; CESC cis rs2072499 1.000 rs2241107 chr1:156182710 C/T cg25208724 chr1:156163844 SLC25A44 -0.91 -16.91 -0.72 5.25e-44 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22511408 chr5:6378790 MED10 0.58 6.44 0.37 5.73e-10 Gut microbiome composition (summer); CESC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg04772025 chr11:68637568 NA 0.51 6.02 0.35 5.83e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9837602 0.938 rs9873709 chr3:99711687 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.48 6.78 0.38 7.72e-11 Breast cancer; CESC trans rs11098499 0.780 rs10013652 chr4:120292256 A/G cg25214090 chr10:38739885 LOC399744 0.66 9.1 0.49 2.19e-17 Corneal astigmatism; CESC cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg02187348 chr16:89574699 SPG7 0.56 7.66 0.43 3.52e-13 Multiple myeloma (IgH translocation); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26708280 chr2:190649305 PMS1;ORMDL1 -0.5 -6.3 -0.36 1.24e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2637266 0.905 rs11001834 chr10:78360494 T/C cg18941641 chr10:78392320 NA 0.4 7.45 0.42 1.35e-12 Pulmonary function; CESC cis rs1707322 0.686 rs3014239 chr1:46089801 G/A cg06784218 chr1:46089804 CCDC17 -0.42 -7.37 -0.41 2.13e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2228479 0.717 rs2074904 chr16:89811546 A/G cg19635926 chr16:89946313 TCF25 0.68 5.17 0.3 4.67e-7 Skin colour saturation; CESC cis rs858239 0.600 rs10235786 chr7:23139940 T/C cg23682824 chr7:23144976 KLHL7 0.52 7.1 0.4 1.16e-11 Cerebrospinal fluid biomarker levels; CESC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs2522056 1.000 rs2706395 chr5:131796803 A/T cg24060327 chr5:131705240 SLC22A5 0.59 6.63 0.38 1.85e-10 Lymphocyte counts;Fibrinogen; CESC cis rs9443189 0.762 rs2647417 chr6:76435943 A/G cg01950844 chr6:76311363 SENP6 -0.69 -7.55 -0.42 7.2e-13 Prostate cancer; CESC cis rs861020 0.606 rs627459 chr1:210004682 C/G cg05527609 chr1:210001259 C1orf107 0.74 9.71 0.51 2.88e-19 Orofacial clefts; CESC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.04 0.49 3.4e-17 Tonsillectomy; CESC cis rs796364 0.951 rs281776 chr2:200834282 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 8.38 0.46 3.1e-15 Schizophrenia; CESC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg22968622 chr17:43663579 NA -1.19 -16.22 -0.71 1.43e-41 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs643506 0.817 rs1940392 chr11:111776846 G/A cg17089665 chr11:111648010 NA -0.38 -5.45 -0.32 1.17e-7 Breast cancer; CESC cis rs7818345 0.935 rs7016259 chr8:19277530 A/G cg11303988 chr8:19266685 CSGALNACT1 0.32 5.84 0.34 1.56e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs4969178 0.930 rs2292644 chr17:76394449 C/T cg05887092 chr17:76393375 PGS1 0.57 9.02 0.48 3.94e-17 HDL cholesterol levels; CESC trans rs78049276 0.736 rs6842241 chr4:148400819 C/A cg13149281 chr14:23389818 RBM23;PRMT5 -0.74 -9.02 -0.48 4.04e-17 Pulse pressure; CESC cis rs1568889 1.000 rs11604085 chr11:28141002 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 9.44 0.5 2.08e-18 Bipolar disorder; CESC cis rs11122272 0.735 rs2790883 chr1:231532726 A/G cg06096015 chr1:231504339 EGLN1 0.44 6.37 0.36 8.28e-10 Hemoglobin concentration; CESC trans rs1814175 0.669 rs12364577 chr11:49707361 A/C cg03929089 chr4:120376271 NA -0.72 -9.28 -0.5 6.08e-18 Height; CESC cis rs6582630 0.555 rs10880602 chr12:38505660 T/C cg26384229 chr12:38710491 ALG10B 0.65 9.78 0.51 1.78e-19 Drug-induced liver injury (flucloxacillin); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06324094 chr1:153950482 JTB -0.42 -6.2 -0.36 2.14e-9 Gambling; CESC cis rs35110281 0.805 rs2838318 chr21:44991825 G/A cg01579765 chr21:45077557 HSF2BP -0.51 -8.76 -0.47 2.32e-16 Mean corpuscular volume; CESC cis rs2963155 0.518 rs2963151 chr5:142734151 T/C cg17617527 chr5:142782415 NR3C1 0.84 7.96 0.44 5.19e-14 Breast cancer; CESC cis rs7301826 0.934 rs10773826 chr12:131321174 C/G cg11011512 chr12:131303247 STX2 0.44 5.54 0.32 7.24e-8 Plasma plasminogen activator levels; CESC cis rs6741892 0.536 rs6761563 chr2:38891406 A/T cg19391498 chr2:38892846 GALM -0.54 -7.06 -0.4 1.48e-11 5-HTT brain serotonin transporter levels; CESC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg07308232 chr7:1071921 C7orf50 -0.45 -6.25 -0.36 1.67e-9 Longevity;Endometriosis; CESC cis rs748404 0.690 rs2467737 chr15:43737188 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.6 0.42 5e-13 Lung cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03973167 chr4:185394988 IRF2 -0.42 -6.03 -0.35 5.44e-9 Gambling; CESC cis rs2952156 1.000 rs1565923 chr17:37858678 A/G cg20243544 chr17:37824526 PNMT 0.62 7.53 0.42 7.8e-13 Asthma; CESC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg17366294 chr4:99064904 C4orf37 0.63 8.7 0.47 3.53e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9303401 0.632 rs9915267 chr17:57244907 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.55 7.12 0.4 1.02e-11 Cognitive test performance; CESC cis rs1008375 0.966 rs12509962 chr4:17680292 G/A cg16339924 chr4:17578868 LAP3 0.5 6.44 0.37 5.52e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg17971929 chr21:40555470 PSMG1 -0.86 -12.63 -0.61 6.31e-29 Cognitive function; CESC cis rs7666738 0.546 rs7679681 chr4:98882221 A/G cg05340658 chr4:99064831 C4orf37 0.58 7.31 0.41 3.1e-12 Colonoscopy-negative controls vs population controls; CESC cis rs11025559 0.796 rs11603462 chr11:20412180 C/A cg19653624 chr11:20408972 PRMT3 -0.46 -5.43 -0.32 1.27e-7 Pursuit maintenance gain; CESC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg18402987 chr7:1209562 NA 0.75 7.57 0.42 6.17e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2228479 0.681 rs7199685 chr16:89959805 G/C cg00800038 chr16:89945340 TCF25 -0.61 -6.76 -0.38 8.84e-11 Skin colour saturation; CESC cis rs5167 0.586 rs4803774 chr19:45450872 A/G cg20090143 chr19:45452003 APOC2 0.38 6.49 0.37 4.3e-10 Blood protein levels; CESC cis rs7843479 0.601 rs10109521 chr8:21829948 G/A cg17168535 chr8:21777572 XPO7 0.75 11.75 0.59 6.18e-26 Mean corpuscular volume; CESC cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg15556689 chr8:8085844 FLJ10661 0.61 7.26 0.41 4.35e-12 Mood instability; CESC cis rs2115630 1.000 rs58581703 chr15:85276935 C/T cg12501888 chr15:85177176 SCAND2 -0.39 -5.05 -0.3 8.2e-7 P wave terminal force; CESC cis rs4722166 0.630 rs4722168 chr7:22779002 G/A cg05265849 chr7:22767390 IL6 0.57 7.11 0.4 1.06e-11 Lung cancer; CESC cis rs7312933 0.584 rs6582391 chr12:42634686 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 6.03 0.35 5.34e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg00684032 chr4:1343700 KIAA1530 0.43 6.08 0.35 4.16e-9 Obesity-related traits; CESC cis rs6032067 0.777 rs13037087 chr20:43834313 T/C cg10761708 chr20:43804764 PI3 0.52 6.32 0.36 1.07e-9 Blood protein levels; CESC cis rs921968 0.544 rs58827325 chr2:219415166 A/T cg02176678 chr2:219576539 TTLL4 0.5 9.06 0.49 3.06e-17 Mean corpuscular hemoglobin concentration; CESC cis rs6540559 0.673 rs17317411 chr1:209961314 C/T cg22029157 chr1:209979665 IRF6 -0.71 -7.56 -0.42 6.67e-13 Cleft lip with or without cleft palate; CESC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg20243544 chr17:37824526 PNMT 0.5 6.23 0.36 1.8e-9 Glomerular filtration rate (creatinine); CESC cis rs2708240 0.967 rs1922892 chr7:147576411 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.78 -0.33 2.12e-8 QT interval (drug interaction); CESC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg12311346 chr5:56204834 C5orf35 -0.66 -8.8 -0.48 1.74e-16 Initial pursuit acceleration; CESC cis rs1865721 0.728 rs7232269 chr18:73219023 G/A cg26385618 chr18:73139727 C18orf62 -0.53 -7.75 -0.43 2.02e-13 Intelligence; CESC cis rs12136530 0.593 rs12136926 chr1:19710794 G/A cg15026089 chr1:19640712 PQLC2 0.33 5.08 0.3 7.13e-7 Lead levels in blood; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19917744 chr2:208890468 PLEKHM3 -0.43 -6.16 -0.35 2.65e-9 Gut microbiota (bacterial taxa); CESC cis rs9300255 0.602 rs1616181 chr12:123619856 T/A cg00376283 chr12:123451042 ABCB9 0.71 8.71 0.47 3.37e-16 Neutrophil percentage of white cells; CESC cis rs6540559 0.673 rs114467813 chr1:210017785 G/A cg22029157 chr1:209979665 IRF6 0.73 7.62 0.42 4.41e-13 Cleft lip with or without cleft palate; CESC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg02569458 chr12:86230093 RASSF9 0.52 7.66 0.43 3.46e-13 Major depressive disorder; CESC cis rs9814567 0.712 rs4245905 chr3:134328864 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.09 -0.3 6.84e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2204008 0.744 rs8186814 chr12:38335169 C/T cg26384229 chr12:38710491 ALG10B 0.73 10.9 0.56 4.29e-23 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02365862 chr6:7541556 DSP 0.6 6.52 0.37 3.55e-10 Gut microbiome composition (summer); CESC cis rs1707322 0.681 rs12048866 chr1:46117492 T/G cg06784218 chr1:46089804 CCDC17 0.41 7.12 0.4 1.04e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2439831 0.850 rs9944216 chr15:44160773 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.63 -5.52 -0.32 8.04e-8 Lung cancer in ever smokers; CESC cis rs367615 0.842 rs2578484 chr5:108950808 G/A cg17395555 chr5:108820864 NA -0.5 -7.06 -0.4 1.49e-11 Colorectal cancer (SNP x SNP interaction); CESC cis rs12249377 0.519 rs7906960 chr10:92586205 A/G cg14313238 chr10:92632228 RPP30 0.43 5.26 0.31 2.92e-7 White matter microstructure (global fractional anisotropy); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14843989 chr17:10600751 C17orf48;SCO1 -0.46 -6.03 -0.35 5.34e-9 Ulcerative colitis; CESC cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg22862634 chr11:62369728 EML3;MTA2 0.6 8.25 0.45 7.24e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg08859206 chr1:53392774 SCP2 -0.58 -7.73 -0.43 2.26e-13 Monocyte count; CESC cis rs78456975 1.000 rs13414537 chr2:1556330 C/T cg01028140 chr2:1542097 TPO -0.58 -5.9 -0.34 1.1e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg13770153 chr20:60521292 NA -0.46 -6.23 -0.36 1.87e-9 Body mass index; CESC cis rs7208859 0.673 rs423151 chr17:28952286 A/G cg17105886 chr17:28927953 LRRC37B2 0.62 5.49 0.32 9.21e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg00745731 chr19:929724 ARID3A 0.47 6.26 0.36 1.55e-9 Recombination measurement; CESC cis rs9815354 0.857 rs13087502 chr3:42015110 A/G cg03022575 chr3:42003672 ULK4 0.47 5.24 0.31 3.26e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs2243480 0.803 rs34804747 chr7:65412942 G/C cg12463550 chr7:65579703 CRCP 0.69 5.62 0.33 4.79e-8 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17181325 chr17:1613831 TLCD2 0.58 6.91 0.39 3.51e-11 Gut microbiome composition (summer); CESC cis rs2303759 0.676 rs10426452 chr19:49907690 G/A cg22307029 chr19:49891270 CCDC155 0.62 7.43 0.42 1.52e-12 Multiple sclerosis; CESC cis rs3820068 0.608 rs12091750 chr1:16042766 T/C cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.64e-7 Systolic blood pressure; CESC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg06481639 chr22:41940642 POLR3H -0.58 -5.73 -0.33 2.78e-8 Vitiligo; CESC cis rs7044106 0.762 rs3903886 chr9:123383646 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.34 -5.62 -0.33 4.77e-8 Hip circumference adjusted for BMI; CESC trans rs1945213 0.694 rs34828123 chr11:55837868 T/A cg15704280 chr7:45808275 SEPT13 0.76 7.31 0.41 3.15e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs12413816 0.824 rs1571008 chr10:13760776 T/C cg16485048 chr10:13749193 FRMD4A 0.57 7.73 0.43 2.28e-13 Red cell distribution width; CESC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.15 0.79 7.49e-59 Prudent dietary pattern; CESC cis rs2404602 0.679 rs12900494 chr15:76912504 A/G cg26408565 chr15:76604113 ETFA -0.39 -5.49 -0.32 9.6e-8 Blood metabolite levels; CESC cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg23711669 chr6:146136114 FBXO30 -1.04 -15.13 -0.68 1.04e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs1691799 0.899 rs1168308 chr12:66742183 A/G cg16791601 chr12:66731901 HELB -0.75 -12.9 -0.62 7.25e-30 White blood cell count (basophil); CESC cis rs12220238 1.000 rs11000905 chr10:75925532 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.63 6.1 0.35 3.78e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC cis rs637571 0.557 rs1204649 chr11:65702776 A/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 5.89 0.34 1.19e-8 Eosinophil percentage of white cells; CESC trans rs1814175 0.817 rs6486044 chr11:49982718 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -20.41 -0.78 2.75e-56 Height; CESC cis rs1008375 1.000 rs917665 chr4:17668504 A/C cg16339924 chr4:17578868 LAP3 -0.45 -5.53 -0.32 7.65e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg05347473 chr6:146136440 FBXO30 0.59 7.63 0.42 4.24e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs861020 1.000 rs595918 chr1:209966843 A/G cg05527609 chr1:210001259 C1orf107 0.99 12.22 0.6 1.57e-27 Orofacial clefts; CESC cis rs36229146 1 rs36229146 chr7:22784486 TTATATATAAATATATATATATATATA/T cg13104385 chr7:22767384 IL6 0.47 6.08 0.35 4.1e-9 Eosinophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CESC trans rs1814175 0.817 rs11040474 chr11:49708441 G/A cg03929089 chr4:120376271 NA -0.91 -14.83 -0.67 1.26e-36 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22428961 chr1:2344426 PEX10 0.61 7.12 0.4 1e-11 Gut microbiome composition (summer); CESC cis rs9399135 0.935 rs6908681 chr6:135337733 A/G cg22676075 chr6:135203613 NA 0.52 7.42 0.41 1.61e-12 Red blood cell count; CESC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03352830 chr11:487213 PTDSS2 0.71 7.25 0.41 4.71e-12 Body mass index; CESC cis rs3762637 0.823 rs59569049 chr3:122238788 A/T cg24169773 chr3:122142474 KPNA1 -0.59 -6.88 -0.39 4.42e-11 LDL cholesterol levels; CESC cis rs1577917 0.958 rs67024565 chr6:86553997 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -6.57 -0.37 2.64e-10 Response to antipsychotic treatment; CESC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.71 0.38 1.18e-10 Bipolar disorder; CESC cis rs425277 0.958 rs262660 chr1:2086757 A/G cg16545954 chr1:2118288 C1orf86 0.33 5.59 0.32 5.57e-8 Height; CESC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9900062 0.546 rs2428352 chr17:62694738 C/T cg02097616 chr17:62675921 NA -0.43 -5.38 -0.31 1.63e-7 QT interval; CESC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg15112475 chr7:1198522 ZFAND2A -0.36 -5.81 -0.34 1.78e-8 Longevity;Endometriosis; CESC cis rs4843747 0.641 rs11117353 chr16:88090895 A/G cg17633681 chr16:88106987 BANP 0.68 8.95 0.48 6.21e-17 Menopause (age at onset); CESC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg26587870 chr6:27730563 NA 0.48 5.21 0.3 3.76e-7 Depression; CESC cis rs1957429 0.901 rs1957434 chr14:65349909 C/T cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg25405998 chr7:65216604 CCT6P1 0.45 5.06 0.3 7.71e-7 Aortic root size; CESC cis rs7917772 0.636 rs7897384 chr10:104529042 T/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.45 -5.32 -0.31 2.2e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs4245128 0.930 rs4245127 chr11:112791864 T/C cg10894232 chr8:11772343 NA 0.37 6.1 0.35 3.78e-9 Life satisfaction; CESC cis rs2439831 0.681 rs11858152 chr15:43634196 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.85 12.88 0.62 8.26e-30 Lung cancer in ever smokers; CESC cis rs9902453 0.904 rs7213076 chr17:28419428 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -9.02 -0.48 3.81e-17 Coffee consumption (cups per day); CESC cis rs34779708 0.966 rs12774834 chr10:35400070 A/T cg04310649 chr10:35416472 CREM -0.52 -6.25 -0.36 1.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs4604732 0.588 rs9943231 chr1:247629829 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.47 5.82 0.34 1.73e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6598955 0.724 rs884533 chr1:26585657 G/T cg04990556 chr1:26633338 UBXN11 -0.79 -11.43 -0.57 7.15e-25 Obesity-related traits; CESC cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.07 0.3 7.34e-7 Colonoscopy-negative controls vs population controls; CESC cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 5.99 0.35 6.92e-9 Colorectal cancer; CESC cis rs6754311 0.731 rs218174 chr2:136658345 C/T cg07169764 chr2:136633963 MCM6 -0.69 -8.58 -0.47 8.13e-16 Mosquito bite size; CESC cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg23711669 chr6:146136114 FBXO30 1.02 15.62 0.69 2.01e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.64 -0.33 4.29e-8 Aortic root size; CESC cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg11279151 chr3:101281821 RG9MTD1 0.51 5.61 0.33 5.07e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6688613 0.649 rs2294195 chr1:166838281 T/C cg07049167 chr1:166818506 POGK 0.44 5.07 0.3 7.39e-7 Refractive astigmatism; CESC cis rs4409675 0.556 rs2064710 chr1:28231154 G/A cg23691781 chr1:28212827 C1orf38 0.28 5.64 0.33 4.46e-8 Corneal astigmatism; CESC cis rs6430585 0.528 rs660002 chr2:136723504 C/T cg07169764 chr2:136633963 MCM6 1.1 16.89 0.72 6.1e-44 Corneal structure; CESC cis rs6088580 0.634 rs4911153 chr20:32961547 C/T cg08999081 chr20:33150536 PIGU -0.64 -11.05 -0.56 1.38e-23 Glomerular filtration rate (creatinine); CESC cis rs5758659 0.653 rs133383 chr22:42473603 C/T cg19513890 chr22:42538836 CYP2D7P1 -0.38 -5.62 -0.33 4.73e-8 Cognitive function; CESC cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg22875332 chr1:76189707 ACADM -0.63 -6.66 -0.38 1.6e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg05585544 chr11:47624801 NA -0.46 -6.74 -0.38 9.81e-11 Subjective well-being; CESC cis rs9596863 1.000 rs9568939 chr13:54411497 A/C ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs11229555 0.834 rs7925560 chr11:58263036 G/A cg15696309 chr11:58395628 NA -0.42 -5.2 -0.3 3.98e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg03609598 chr5:56110824 MAP3K1 -0.51 -5.32 -0.31 2.22e-7 Initial pursuit acceleration; CESC cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg26335602 chr6:28129616 ZNF389 0.52 6.84 0.39 5.58e-11 Depression; CESC cis rs6570726 1.000 rs1935617 chr6:145943326 C/T cg23711669 chr6:146136114 FBXO30 0.7 10.28 0.53 4.29e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg00166722 chr3:10149974 C3orf24 0.5 6.35 0.36 9.36e-10 Alzheimer's disease; CESC cis rs897984 0.542 rs11864839 chr16:31095251 G/C cg00531865 chr16:30841666 NA -0.4 -5.54 -0.32 7.3900000000000007e-08 Dementia with Lewy bodies; CESC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg20243544 chr17:37824526 PNMT -0.48 -6.1 -0.35 3.8e-9 Glomerular filtration rate (creatinine); CESC cis rs11690935 0.959 rs67204065 chr2:172672624 G/A cg13550731 chr2:172543902 DYNC1I2 -0.92 -13.72 -0.64 1.02e-32 Schizophrenia; CESC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg22143856 chr6:28129313 ZNF389 0.44 5.49 0.32 9.24e-8 Parkinson's disease; CESC trans rs11764590 0.671 rs17734969 chr7:2110517 T/C cg11693508 chr17:37793320 STARD3 0.66 7.13 0.4 9.32e-12 Neuroticism; CESC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg18402987 chr7:1209562 NA 0.76 7.58 0.42 5.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7824557 0.564 rs2736294 chr8:11234626 T/C cg21775007 chr8:11205619 TDH -0.54 -8.08 -0.44 2.28e-14 Retinal vascular caliber; CESC cis rs9300255 0.602 rs2851438 chr12:123643689 T/C cg19016782 chr12:123741754 C12orf65 -0.4 -5.77 -0.33 2.27e-8 Neutrophil percentage of white cells; CESC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.64 5.51 0.32 8.38e-8 Depression; CESC cis rs57244997 0.725 rs73028496 chr6:162422243 A/G cg17173639 chr6:162384350 PARK2 -0.49 -5.66 -0.33 3.98e-8 Mosquito bite size; CESC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg08470875 chr2:26401718 FAM59B -0.47 -5.24 -0.31 3.31e-7 Gut microbiome composition (summer); CESC cis rs28647808 0.881 rs7042326 chr9:136266636 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC cis rs9644630 0.897 rs6984644 chr8:19363425 C/T cg01280390 chr8:19363452 CSGALNACT1 0.34 5.22 0.31 3.6e-7 Oropharynx cancer; CESC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg24060327 chr5:131705240 SLC22A5 0.76 10.65 0.55 2.72e-22 Breast cancer; CESC cis rs9527 0.614 rs11191589 chr10:104930382 T/C cg04362960 chr10:104952993 NT5C2 0.42 5.25 0.31 3.11e-7 Arsenic metabolism; CESC cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg25019033 chr10:957182 NA -0.59 -6.33 -0.36 1.02e-9 Eosinophil percentage of granulocytes; CESC trans rs561341 1.000 rs561341 chr17:30316385 T/G cg20587970 chr11:113659929 NA -1.41 -18.23 -0.75 1.08e-48 Hip circumference adjusted for BMI; CESC cis rs79149102 0.649 rs75725543 chr15:75097737 T/C cg09165964 chr15:75287851 SCAMP5 -0.71 -5.26 -0.31 2.97e-7 Lung cancer; CESC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg12963246 chr6:28129442 ZNF389 0.5 6.4 0.37 6.93e-10 Parkinson's disease; CESC cis rs12586317 0.547 rs10130773 chr14:35445299 G/A cg05294307 chr14:35346193 BAZ1A -0.49 -5.37 -0.31 1.75e-7 Psoriasis; CESC cis rs3126085 0.935 rs1496050 chr1:152163549 T/C cg26876637 chr1:152193138 HRNR 0.44 5.12 0.3 5.85e-7 Atopic dermatitis; CESC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg08888203 chr3:10149979 C3orf24 0.55 7.2 0.4 6.16e-12 Alzheimer's disease; CESC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg07092213 chr7:1199455 ZFAND2A -0.51 -5.99 -0.35 6.78e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2485892 0.553 rs2494191 chr1:210346053 G/C cg21951975 chr1:209979733 IRF6 0.47 5.82 0.34 1.66e-8 Manic episodes in bipolar disorder; CESC cis rs654950 0.875 rs2759248 chr1:41990795 T/C cg06885757 chr1:42089581 HIVEP3 -0.43 -6.7 -0.38 1.27e-10 Airway imaging phenotypes; CESC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.03 0.3 9.21e-7 Personality dimensions; CESC cis rs28374715 0.578 rs7165914 chr15:41632451 C/T cg02330683 chr15:41787940 ITPKA 0.49 5.72 0.33 2.93e-8 Ulcerative colitis; CESC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg08109568 chr15:31115862 NA -0.71 -9.44 -0.5 2.03e-18 Huntington's disease progression; CESC cis rs752010 0.715 rs4083592 chr1:42099522 A/G cg06885757 chr1:42089581 HIVEP3 0.7 10.86 0.56 5.6e-23 Lupus nephritis in systemic lupus erythematosus; CESC cis rs561341 1.000 rs8070262 chr17:30262467 A/G cg00745463 chr17:30367425 LRRC37B -0.49 -5.29 -0.31 2.57e-7 Hip circumference adjusted for BMI; CESC cis rs1144713 1.000 rs1144713 chr12:32261239 A/G cg01321189 chr12:32259338 BICD1 0.39 6.17 0.35 2.53e-9 Obesity-related traits; CESC cis rs11785400 0.701 rs9297968 chr8:143723009 A/G cg24634471 chr8:143751801 JRK 0.43 5.57 0.32 6.39e-8 Schizophrenia; CESC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.88 7.6 0.42 5.11e-13 Depression; CESC cis rs7296418 0.961 rs12425850 chr12:123501972 T/C cg00376283 chr12:123451042 ABCB9 0.75 10.88 0.56 4.77e-23 Platelet count; CESC cis rs1595825 0.891 rs59938443 chr2:198497105 C/T cg10820045 chr2:198174542 NA 0.4 5.07 0.3 7.53e-7 Ulcerative colitis; CESC cis rs950027 0.620 rs1153862 chr15:45631868 A/G cg21132104 chr15:45694354 SPATA5L1 0.67 8.72 0.47 3.16e-16 Response to fenofibrate (adiponectin levels); CESC cis rs1371867 0.875 rs1962901 chr8:101326428 A/G cg11906718 chr8:101322791 RNF19A 0.46 5.92 0.34 1.02e-8 Atrioventricular conduction; CESC cis rs9929218 0.508 rs1559366 chr16:68799611 A/G cg02972257 chr16:68554789 NA -0.42 -5.3 -0.31 2.41e-7 Colorectal cancer; CESC cis rs3750965 0.920 rs4930644 chr11:68819097 C/T cg01403660 chr11:68851641 TPCN2 0.44 5.6 0.33 5.45e-8 Hair color; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg04726876 chr9:2017576 SMARCA2 -0.52 -6.33 -0.36 1.06e-9 Subjective well-being; CESC cis rs7100689 0.577 rs1340385 chr10:82058851 G/A cg09936400 chr10:82049201 MAT1A 0.41 6.06 0.35 4.57e-9 Post bronchodilator FEV1; CESC trans rs2797160 0.875 rs12527010 chr6:125991507 A/G cg05039488 chr6:79577232 IRAK1BP1 0.45 6.16 0.35 2.76e-9 Endometrial cancer; CESC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg18446336 chr7:2847575 GNA12 -0.4 -6.02 -0.35 5.71e-9 Height; CESC cis rs1065852 0.526 rs12166549 chr22:42410419 T/C cg22189786 chr22:42395067 WBP2NL 0.41 5.22 0.31 3.55e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs477692 0.789 rs507900 chr10:131398144 A/G cg05714579 chr10:131428358 MGMT -0.45 -5.9 -0.34 1.1e-8 Response to temozolomide; CESC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Depression; CESC cis rs7296418 0.663 rs11057284 chr12:123830692 G/C cg00376283 chr12:123451042 ABCB9 0.56 7.79 0.43 1.53e-13 Platelet count; CESC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg07936489 chr17:37558343 FBXL20 0.8 11.67 0.58 1.17e-25 Glomerular filtration rate (creatinine); CESC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.84e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.863 rs17050695 chr4:120489527 G/T cg24375607 chr4:120327624 NA 0.48 5.89 0.34 1.16e-8 Corneal astigmatism; CESC cis rs7666738 0.830 rs11944855 chr4:99068258 G/A cg05340658 chr4:99064831 C4orf37 0.83 12.82 0.62 1.36e-29 Colonoscopy-negative controls vs population controls; CESC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg09165964 chr15:75287851 SCAMP5 0.46 6.28 0.36 1.36e-9 Breast cancer; CESC cis rs1008375 0.863 rs10003291 chr4:17600728 A/C cg27347728 chr4:17578864 LAP3 0.48 5.57 0.32 6.36e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9399401 0.667 rs6900233 chr6:142717283 C/G cg04461802 chr6:142623433 GPR126 0.42 6.04 0.35 5.13e-9 Chronic obstructive pulmonary disease; CESC cis rs9611519 0.603 rs8142276 chr22:41471447 T/C cg03806693 chr22:41940476 POLR3H -0.43 -5.22 -0.31 3.67e-7 Neuroticism; CESC cis rs9487051 0.676 rs9398196 chr6:109601554 A/G cg12927641 chr6:109611667 NA -0.37 -5.51 -0.32 8.39e-8 Reticulocyte fraction of red cells; CESC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg19717773 chr7:2847554 GNA12 -0.57 -8.18 -0.45 1.18e-14 Height; CESC cis rs9393777 0.623 rs9358948 chr6:26483806 G/A cg14345882 chr6:26364793 BTN3A2 0.43 5.34 0.31 2.01e-7 Intelligence (multi-trait analysis); CESC cis rs13256369 0.802 rs11995449 chr8:8559898 G/A cg18904891 chr8:8559673 CLDN23 0.72 7.86 0.43 9.45e-14 Obesity-related traits; CESC cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg22823121 chr1:150693482 HORMAD1 -0.41 -6.29 -0.36 1.29e-9 Tonsillectomy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00653609 chr6:39082964 C6orf64 0.5 6.33 0.36 1.02e-9 Gut microbiota (bacterial taxa); CESC cis rs9467711 0.523 rs9379853 chr6:26357635 A/G cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.52e-7 Autism spectrum disorder or schizophrenia; CESC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -7.02 -0.4 1.9e-11 Developmental language disorder (linguistic errors); CESC cis rs7528419 0.927 rs660240 chr1:109817838 T/C cg00908766 chr1:109817496 CELSR2 0.47 6.73 0.38 1.05e-10 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CESC cis rs10129255 0.500 rs11628999 chr14:107208446 C/T cg23076370 chr14:107095027 NA -0.64 -9.31 -0.5 5.13e-18 Kawasaki disease; CESC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -6.98 -0.39 2.43e-11 Menopause (age at onset); CESC cis rs3768617 0.811 rs6424883 chr1:183037695 T/C ch.1.3577855R chr1:183094577 LAMC1 0.66 9.15 0.49 1.56e-17 Fuchs's corneal dystrophy; CESC cis rs7927771 1.000 rs10838747 chr11:47716324 G/C cg20307385 chr11:47447363 PSMC3 -0.5 -6.11 -0.35 3.6e-9 Subjective well-being; CESC cis rs11792861 0.926 rs72607173 chr9:111879398 T/G cg05043794 chr9:111880884 C9orf5 -0.4 -6.68 -0.38 1.44e-10 Menarche (age at onset); CESC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg24829409 chr8:58192753 C8orf71 -0.69 -7.68 -0.43 3.13e-13 Developmental language disorder (linguistic errors); CESC cis rs4566357 0.615 rs4675139 chr2:227908527 G/A cg11843606 chr2:227700838 RHBDD1 -0.48 -6.54 -0.37 3.12e-10 Coronary artery disease; CESC cis rs137699 0.959 rs5757631 chr22:39755953 T/C cg05872129 chr22:39784769 NA -0.41 -5.3 -0.31 2.45e-7 IgG glycosylation; CESC cis rs6570726 0.935 rs454370 chr6:145846729 T/G cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.96e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1538970 0.924 rs7528573 chr1:45913860 T/C cg03146154 chr1:46216737 IPP 0.46 5.34 0.31 1.97e-7 Platelet count; CESC cis rs1865721 1.000 rs7244787 chr18:73195162 T/C cg26385618 chr18:73139727 C18orf62 -0.51 -7.56 -0.42 6.81e-13 Intelligence; CESC cis rs12474201 0.928 rs34186074 chr2:46965010 T/C cg06386533 chr2:46925753 SOCS5 0.91 12.78 0.62 1.92e-29 Height; CESC cis rs7666738 0.609 rs35214820 chr4:98864692 G/A cg17366294 chr4:99064904 C4orf37 0.47 5.73 0.33 2.67e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.526 rs2320448 chr12:38224180 G/A cg26384229 chr12:38710491 ALG10B -0.46 -6.06 -0.35 4.66e-9 Bladder cancer; CESC cis rs9818941 1.000 rs4507209 chr3:157710946 T/A cg08654915 chr3:157813417 NA -0.46 -7.77 -0.43 1.72e-13 Height; CESC cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.44 7.15 0.4 8.31e-12 Personality dimensions; CESC cis rs7605827 0.930 rs11692624 chr2:15499127 C/T cg19274914 chr2:15703543 NA 0.32 5.76 0.33 2.35e-8 Educational attainment (years of education); CESC cis rs6460942 0.558 rs4330594 chr7:12278615 G/A cg20607287 chr7:12443886 VWDE -0.55 -5.86 -0.34 1.38e-8 Coronary artery disease; CESC cis rs9300255 0.602 rs884548 chr12:123634122 A/G cg19016782 chr12:123741754 C12orf65 -0.37 -5.04 -0.3 8.55e-7 Neutrophil percentage of white cells; CESC cis rs3540 0.514 rs2601194 chr15:90937051 T/A cg10434728 chr15:90938212 IQGAP1 0.43 7.7 0.43 2.72e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs7582720 1.000 rs72932554 chr2:203845828 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs854765 0.654 rs9911281 chr17:17762457 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.6 -8.95 -0.48 6.29e-17 Total body bone mineral density; CESC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg22823121 chr1:150693482 HORMAD1 0.47 6.51 0.37 3.7e-10 Melanoma; CESC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg04317338 chr11:64019027 PLCB3 0.89 9.33 0.5 4.45e-18 Mean platelet volume; CESC cis rs16858210 0.874 rs11918588 chr3:183601715 C/A cg25686905 chr3:183603175 PARL -0.33 -5.98 -0.35 7.05e-9 Menopause (age at onset); CESC cis rs57221529 0.713 rs56328416 chr5:591138 G/A cg16447950 chr5:562315 NA -0.59 -6.06 -0.35 4.53e-9 Lung disease severity in cystic fibrosis; CESC cis rs6496667 0.509 rs2657948 chr15:90948617 G/A cg10434728 chr15:90938212 IQGAP1 0.32 5.65 0.33 4.22e-8 Rheumatoid arthritis; CESC cis rs9649213 0.586 rs11768599 chr7:97974555 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.44 -5.98 -0.34 7.33e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs8038465 0.571 rs7176654 chr15:73999006 C/T cg15420318 chr15:73925796 NPTN -0.4 -5.95 -0.34 8.37e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4132509 0.779 rs3006940 chr1:243683001 A/G cg21452805 chr1:244014465 NA 0.41 5.12 0.3 5.8e-7 RR interval (heart rate); CESC cis rs10924309 0.737 rs6700721 chr1:245854173 C/T cg00036263 chr1:245852353 KIF26B -0.55 -7.28 -0.41 3.71e-12 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs7772486 0.623 rs9485021 chr6:146068797 A/G cg23711669 chr6:146136114 FBXO30 -0.87 -12.87 -0.62 8.94e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs3749237 0.555 rs2117939 chr3:49415179 C/A cg02487422 chr3:49467188 NICN1 0.53 7.7 0.43 2.74e-13 Resting heart rate; CESC cis rs3015497 0.549 rs10133807 chr14:51151522 G/A cg26011998 chr14:51135199 SAV1 -0.6 -6.65 -0.38 1.65e-10 Mean platelet volume; CESC cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.6 0.47 7.18e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.717 rs28752166 chr1:46213309 G/A cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs694739 0.541 rs61886926 chr11:64133552 C/T cg02228329 chr11:64053129 BAD;GPR137 0.61 7.58 0.42 5.67e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs7134594 0.677 rs1866066 chr12:109858264 A/T cg19025524 chr12:109796872 NA -0.42 -6.15 -0.35 2.8e-9 HDL cholesterol; CESC cis rs10129255 0.500 rs988133 chr14:107184963 A/G cg23076370 chr14:107095027 NA -0.66 -9.85 -0.52 1.01e-19 Kawasaki disease; CESC cis rs7412746 0.611 rs2228099 chr1:150808889 C/G cg04414720 chr1:150670196 GOLPH3L 0.45 6.31 0.36 1.16e-9 Melanoma; CESC cis rs10979 0.931 rs9484770 chr6:143896758 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7178572 0.633 rs4886875 chr15:77838419 C/T cg22256960 chr15:77711686 NA 0.53 6.99 0.39 2.18e-11 Type 2 diabetes; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg16548348 chr22:19842481 GNB1L;C22orf29 -0.45 -6.67 -0.38 1.48e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -11.61 -0.58 1.83e-25 Alzheimer's disease; CESC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg12463550 chr7:65579703 CRCP 0.54 6.92 0.39 3.34e-11 Aortic root size; CESC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.43 5.38 0.31 1.65e-7 Tonsillectomy; CESC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg08499158 chr17:42289980 UBTF -0.47 -5.66 -0.33 4.02e-8 Total body bone mineral density; CESC cis rs2243480 1.000 rs2177703 chr7:65391717 C/A cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC cis rs7107174 1.000 rs901104 chr11:77930499 C/T cg02023728 chr11:77925099 USP35 0.52 6.5 0.37 4.01e-10 Testicular germ cell tumor; CESC trans rs7615952 0.932 rs3811679 chr3:125648283 A/G cg07211511 chr3:129823064 LOC729375 -1.13 -15.25 -0.68 4.15e-38 Blood pressure (smoking interaction); CESC cis rs3768617 0.510 rs10911254 chr1:183088627 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.49e-35 Fuchs's corneal dystrophy; CESC cis rs2857078 0.745 rs4793085 chr17:42320732 A/C cg08499158 chr17:42289980 UBTF 0.42 5.22 0.31 3.57e-7 Red cell distribution width;Reticulocyte count; CESC cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6800768 0.633 rs12498129 chr3:24120454 A/G cg10674438 chr3:24145617 LOC152024 -0.46 -6.3 -0.36 1.24e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg22875332 chr1:76189707 ACADM -0.59 -6.73 -0.38 1.04e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7219021 0.705 rs28635466 chr17:46983820 G/A cg16584676 chr17:46985605 UBE2Z -0.63 -7.84 -0.43 1.14e-13 Schizophrenia or bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21150049 chr12:50677498 LIMA1 -0.44 -6.25 -0.36 1.65e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6598955 0.671 rs12088858 chr1:26643708 C/A cg19743891 chr1:26644573 UBXN11;CD52 0.35 5.09 0.3 6.68e-7 Obesity-related traits; CESC cis rs365132 1.000 rs35977534 chr5:176335231 T/C cg16309518 chr5:176445507 NA -0.41 -6.02 -0.35 5.68e-9 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs1050631 0.564 rs1785931 chr18:33722107 T/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.51e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs425277 0.958 rs262652 chr1:2090816 T/C cg16545954 chr1:2118288 C1orf86 0.33 5.59 0.32 5.57e-8 Height; CESC cis rs6502050 0.835 rs8065037 chr17:80158966 T/G cg23985595 chr17:80112537 CCDC57 -0.4 -6.37 -0.36 8.38e-10 Life satisfaction; CESC cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg16339924 chr4:17578868 LAP3 0.59 7.47 0.42 1.15e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg20243544 chr17:37824526 PNMT 0.49 6.23 0.36 1.85e-9 Glomerular filtration rate (creatinine); CESC cis rs854765 0.583 rs4925129 chr17:17807186 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 5.97 0.34 7.54e-9 Total body bone mineral density; CESC cis rs9486719 1.000 rs2499809 chr6:96870110 C/T cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 1.000 rs2757047 chr6:167374489 C/T cg23791538 chr6:167370224 RNASET2 0.6 8.47 0.46 1.73e-15 Crohn's disease; CESC cis rs4629710 0.592 rs4310080 chr6:131538377 T/G cg12606694 chr6:131520996 AKAP7 0.45 5.55 0.32 6.81e-8 Multiple myeloma (IgH translocation); CESC cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg24112000 chr20:60950667 NA -0.44 -5.4 -0.31 1.5e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs2739330 0.892 rs5751776 chr22:24266954 A/C cg24846343 chr22:24311635 DDTL 0.71 12.77 0.62 2.06e-29 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7586879 0.964 rs6545795 chr2:25116783 C/T cg01884057 chr2:25150051 NA 0.28 5.12 0.3 5.86e-7 Body mass index; CESC cis rs4474465 0.646 rs7936011 chr11:78275931 G/T cg27205649 chr11:78285834 NARS2 0.46 6.07 0.35 4.44e-9 Alzheimer's disease (survival time); CESC cis rs950169 0.763 rs35372971 chr15:84941795 G/A cg17507749 chr15:85114479 UBE2QP1 0.59 6.52 0.37 3.46e-10 Schizophrenia; CESC cis rs68170813 0.599 rs12532849 chr7:106959226 A/C cg02696742 chr7:106810147 HBP1 -0.53 -5.04 -0.3 8.64e-7 Coronary artery disease; CESC trans rs11148252 0.574 rs3742297 chr13:53278067 T/C cg18335740 chr13:41363409 SLC25A15 0.53 7.16 0.4 7.78e-12 Lewy body disease; CESC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg22535103 chr8:58192502 C8orf71 -0.84 -9.44 -0.5 2.04e-18 Developmental language disorder (linguistic errors); CESC cis rs2880765 0.545 rs17553734 chr15:86013059 C/G cg19183879 chr15:85880815 NA 0.32 5.93 0.34 9.5e-9 Coronary artery disease; CESC cis rs2294693 0.945 rs9394755 chr6:41006680 C/T cg14769373 chr6:40998127 UNC5CL 0.39 5.43 0.32 1.27e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs1882538 0.503 rs1345938 chr7:133137867 C/T cg10665199 chr7:133106180 EXOC4 -0.54 -7.42 -0.41 1.57e-12 Intelligence (multi-trait analysis); CESC cis rs5771242 0.776 rs6010198 chr22:50610628 A/G cg08875078 chr22:50639485 SELO -0.51 -5.94 -0.34 8.72e-9 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC cis rs7903847 0.642 rs11817875 chr10:99158414 G/A cg20016023 chr10:99160130 RRP12 -0.3 -5.16 -0.3 4.81e-7 Granulocyte percentage of myeloid white cells; CESC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg05863683 chr7:1912471 MAD1L1 0.39 5.64 0.33 4.45e-8 Bipolar disorder and schizophrenia; CESC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg11890956 chr21:40555474 PSMG1 -0.6 -8.25 -0.45 7.41e-15 Menarche (age at onset); CESC cis rs9908102 0.740 rs7211501 chr17:12917479 A/G cg26162695 chr17:12921313 ELAC2 0.55 5.9 0.34 1.12e-8 Schizophrenia; CESC cis rs8072100 0.640 rs3851808 chr17:45425144 C/T cg08085267 chr17:45401833 C17orf57 -0.53 -6.65 -0.38 1.65e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9488822 0.636 rs12524932 chr6:116330266 G/A cg05304507 chr6:116381966 FRK 0.25 6.49 0.37 4.22e-10 Cholesterol, total;LDL cholesterol; CESC cis rs9815354 0.812 rs73069240 chr3:41950973 A/T cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.9e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.84 0.34 1.51e-8 Bipolar disorder; CESC cis rs1062177 1.000 rs2915877 chr5:151150601 C/G cg00977110 chr5:151150581 G3BP1 0.67 7.15 0.4 8.3e-12 Preschool internalizing problems; CESC cis rs10905065 0.804 rs2380203 chr10:5810897 A/G cg11519256 chr10:5708881 ASB13 0.4 5.27 0.31 2.84e-7 Menopause (age at onset); CESC cis rs1577917 0.958 rs12203457 chr6:86689277 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -5.57 -0.32 6.1e-8 Response to antipsychotic treatment; CESC cis rs9611565 0.840 rs9607799 chr22:41777558 A/G cg06481639 chr22:41940642 POLR3H -0.6 -6.44 -0.37 5.59e-10 Vitiligo; CESC cis rs11209002 0.567 rs983110 chr1:67539215 A/T cg02640540 chr1:67518911 SLC35D1 0.47 5.39 0.31 1.52e-7 Crohn's disease; CESC cis rs7647973 1.000 rs74471041 chr3:49542543 T/G cg02487422 chr3:49467188 NICN1 -0.41 -5.36 -0.31 1.81e-7 Menarche (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02615117 chr20:36034986 NA 0.41 6.11 0.35 3.51e-9 Fibrinogen levels; CESC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg24399712 chr22:39784796 NA -0.8 -11.16 -0.57 6.02e-24 Intelligence (multi-trait analysis); CESC cis rs6740322 0.643 rs13390381 chr2:43534414 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.5 -5.07 -0.3 7.57e-7 Coronary artery disease; CESC cis rs261532 0.953 rs446588 chr5:138987756 G/C cg10513866 chr5:139070639 NA 0.33 5.17 0.3 4.52e-7 Immune reponse to smallpox (secreted IFN-alpha); CESC cis rs2243480 1.000 rs13310597 chr7:65598540 A/G cg18252515 chr7:66147081 NA -1.41 -14.36 -0.66 5.44e-35 Diabetic kidney disease; CESC cis rs4664293 0.967 rs7597482 chr2:160547091 T/A cg08347373 chr2:160653686 CD302 -0.31 -5.09 -0.3 6.83e-7 Monocyte percentage of white cells; CESC cis rs6598955 0.724 rs869683 chr1:26570993 T/A cg00852783 chr1:26633632 UBXN11 0.42 6.29 0.36 1.34e-9 Obesity-related traits; CESC cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.44 -0.32 1.19e-7 Huntington's disease progression; CESC cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2645424 0.671 rs2294138 chr8:11705139 C/T cg21281001 chr8:11725306 CTSB 0.5 6.2 0.36 2.18e-9 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); CESC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.02 0.56 1.64e-23 Alzheimer's disease; CESC cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg22834771 chr12:69754056 YEATS4 -0.48 -6.46 -0.37 4.87e-10 Blood protein levels; CESC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg06634786 chr22:41940651 POLR3H -0.68 -7.02 -0.4 1.86e-11 Vitiligo; CESC cis rs950169 0.887 rs220333 chr15:85091133 C/T cg17507749 chr15:85114479 UBE2QP1 0.58 6.47 0.37 4.82e-10 Schizophrenia; CESC cis rs116095464 0.542 rs28650039 chr5:273954 C/A cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.37 0.31 1.76e-7 Breast cancer; CESC cis rs9894429 0.789 rs8074989 chr17:79598728 G/C cg13777783 chr17:79615861 NA -0.33 -5.23 -0.31 3.45e-7 Eye color traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10612046 chr4:39640456 C4orf34 -0.48 -6.3 -0.36 1.26e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.27 0.31 2.88e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.75 -9.3 -0.5 5.56e-18 Multiple sclerosis; CESC cis rs7771547 0.573 rs664370 chr6:36393816 A/G cg04289385 chr6:36355825 ETV7 0.39 5.75 0.33 2.44e-8 Platelet distribution width; CESC cis rs10876993 0.890 rs1689584 chr12:58081478 G/A cg18357645 chr12:58087776 OS9 0.63 10.59 0.55 4.28e-22 Celiac disease or Rheumatoid arthritis; CESC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.4 0.31 1.51e-7 Menopause (age at onset); CESC cis rs4919694 0.667 rs75890466 chr10:105076383 C/T cg04362960 chr10:104952993 NT5C2 0.72 5.71 0.33 2.99e-8 Arsenic metabolism; CESC cis rs1348850 0.567 rs7605493 chr2:178534983 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 6.95 0.39 2.92e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs17764205 0.568 rs72987040 chr19:3251116 C/A cg03776506 chr16:30581384 ZNF688 -0.78 -6.02 -0.35 5.68e-9 Bipolar disorder and schizophrenia; CESC cis rs8170 0.603 rs7249329 chr19:17423373 G/T cg04749549 chr19:17459798 NA -0.34 -5.31 -0.31 2.31e-7 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CESC cis rs61931739 0.500 rs10844789 chr12:34202279 C/G cg19457237 chr12:34500585 NA -0.38 -5.33 -0.31 2.12e-7 Morning vs. evening chronotype; CESC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg08888203 chr3:10149979 C3orf24 0.48 6.09 0.35 3.99e-9 Alzheimer's disease; CESC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg13393036 chr8:95962371 TP53INP1 -0.5 -10.81 -0.55 8.28e-23 Type 2 diabetes; CESC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg06420487 chr17:61919686 SMARCD2 0.46 5.49 0.32 9.46e-8 Height; CESC cis rs67311347 0.544 rs9864664 chr3:40336226 T/C cg09455208 chr3:40491958 NA 0.37 6.51 0.37 3.82e-10 Renal cell carcinoma; CESC cis rs936229 0.813 rs8033381 chr15:75080685 G/A cg14664628 chr15:75095509 CSK -0.95 -14.32 -0.66 8.02e-35 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs854765 0.583 rs6502619 chr17:17779704 C/G cg16928487 chr17:17741425 SREBF1 0.61 10.65 0.55 2.81e-22 Total body bone mineral density; CESC cis rs2637266 1.000 rs2395384 chr10:78335329 G/A cg18941641 chr10:78392320 NA 0.43 7.93 0.44 6.22e-14 Pulmonary function; CESC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg04944784 chr2:26401820 FAM59B -0.96 -10.43 -0.54 1.41e-21 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24810594 chr8:23104082 CHMP7 0.57 6.62 0.38 2.03e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.45 0.32 1.17e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11487532 chr11:44586968 CD82 0.62 7.6 0.42 5.22e-13 Gut microbiome composition (summer); CESC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg08736216 chr1:53307985 ZYG11A -0.41 -6.6 -0.38 2.25e-10 Monocyte count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17675882 chr20:35374068 NDRG3 0.52 6.71 0.38 1.17e-10 Gut microbiota (bacterial taxa); CESC cis rs7212590 0.655 rs56198517 chr17:57976582 G/T cg20303301 chr17:57937339 TUBD1 -0.55 -5.46 -0.32 1.08e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs2777491 1.000 rs316605 chr15:41771591 G/A cg20272979 chr15:41787780 ITPKA 0.43 6.44 0.37 5.63e-10 Ulcerative colitis; CESC cis rs1506636 1.000 rs12706545 chr7:123348744 C/T cg03229431 chr7:123269106 ASB15 -0.5 -6.79 -0.39 7.28e-11 Plateletcrit;Platelet count; CESC cis rs3126085 0.866 rs3126066 chr1:152276871 A/G cg03465714 chr1:152285911 FLG 0.42 5.09 0.3 6.7e-7 Atopic dermatitis; CESC cis rs8060686 0.516 rs8048365 chr16:68253326 T/A cg26727032 chr16:67993705 SLC12A4 -0.59 -8.5 -0.46 1.38e-15 HDL cholesterol;Metabolic syndrome; CESC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.91 0.62 6.41e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 1.000 rs302840 chr17:56673079 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.23 0.31 3.51e-7 Intelligence (multi-trait analysis); CESC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs7100689 0.646 rs7098045 chr10:82123856 G/C cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05998639 chr12:1639527 NA 0.54 6.02 0.35 5.64e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12680326 chr20:2821316 VPS16;FAM113A -0.45 -6.14 -0.35 3.02e-9 Fibrinogen levels; CESC cis rs10927875 0.632 rs10927864 chr1:16165661 C/G cg18973939 chr1:16164122 FLJ37453 0.36 5.38 0.31 1.6e-7 Dilated cardiomyopathy; CESC cis rs8077889 1.000 rs113919636 chr17:41877740 A/C cg26893861 chr17:41843967 DUSP3 0.69 8.2 0.45 1.08e-14 Triglycerides; CESC cis rs34779708 0.733 rs12243593 chr10:35549045 C/T cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs963731 0.649 rs297141 chr2:39319382 T/C cg04010122 chr2:39346883 SOS1 -0.74 -5.39 -0.31 1.54e-7 Corticobasal degeneration; CESC cis rs1577917 1.000 rs10455449 chr6:86592226 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.23 -0.36 1.83e-9 Response to antipsychotic treatment; CESC cis rs868036 1.000 rs868036 chr15:68055013 T/A cg08079166 chr15:68083412 MAP2K5 -0.42 -6.51 -0.37 3.73e-10 Restless legs syndrome; CESC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg20243544 chr17:37824526 PNMT -0.48 -6.07 -0.35 4.4e-9 Glomerular filtration rate (creatinine); CESC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg09165964 chr15:75287851 SCAMP5 0.46 6.31 0.36 1.17e-9 Breast cancer; CESC cis rs12477438 0.765 rs6542846 chr2:99563654 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -8.75 -0.47 2.56e-16 Chronic sinus infection; CESC cis rs75477785 0.590 rs2298930 chr1:209896212 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 -0.86 -5.44 -0.32 1.22e-7 Cleft lip with or without cleft palate; CESC cis rs7772486 0.875 rs9399573 chr6:146403255 A/T cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.99e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7103648 0.630 rs7120548 chr11:47662932 A/G cg10504702 chr11:47789108 FNBP4 0.43 5.48 0.32 9.91e-8 Diastolic blood pressure;Systolic blood pressure; CESC cis rs116095464 0.558 rs9687621 chr5:229194 C/T cg22496380 chr5:211416 CCDC127 -1.0 -10.33 -0.54 3.05e-21 Breast cancer; CESC cis rs11608355 0.545 rs11615336 chr12:109914802 C/A cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs55728055 1.000 rs55728055 chr22:32093268 G/C cg01338084 chr22:32026380 PISD 1.25 8.16 0.45 1.39e-14 Age-related hearing impairment; CESC cis rs921968 0.613 rs1427445 chr2:219555573 C/A cg02176678 chr2:219576539 TTLL4 -0.45 -8.04 -0.44 2.96e-14 Mean corpuscular hemoglobin concentration; CESC cis rs9815354 0.597 rs73075211 chr3:42033424 G/T cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs9399135 0.967 rs12526055 chr6:135325918 C/T cg22676075 chr6:135203613 NA 0.49 6.77 0.38 8.23e-11 Red blood cell count; CESC cis rs2651899 0.934 rs10909887 chr1:3087373 A/T cg22674798 chr1:3096360 PRDM16 -0.39 -7.48 -0.42 1.08e-12 Migraine; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg09068198 chr2:65357064 RAB1A 0.45 6.03 0.35 5.39e-9 Weight; CESC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg11494091 chr17:61959527 GH2 0.73 12.57 0.61 9.63e-29 Prudent dietary pattern; CESC cis rs34779708 0.966 rs17591781 chr10:35498538 G/A cg03585969 chr10:35415529 CREM 0.75 9.88 0.52 8.37e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs1348850 0.750 rs13031008 chr2:178477114 G/A cg23306229 chr2:178417860 TTC30B 0.52 6.49 0.37 4.2e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6963495 0.745 rs73192151 chr7:105211876 A/G cg13798780 chr7:105162888 PUS7 0.77 7.56 0.42 6.63e-13 Bipolar disorder (body mass index interaction); CESC cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg26597838 chr10:835615 NA 0.81 8.56 0.47 9.03e-16 Eosinophil percentage of granulocytes; CESC cis rs7914558 0.966 rs7085598 chr10:104650128 T/C cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.45e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7116495 0.609 rs2852365 chr11:71715218 T/C cg07596299 chr11:71824057 C11orf51 -0.8 -5.4 -0.31 1.49e-7 Severe influenza A (H1N1) infection; CESC cis rs9287719 0.967 rs6432118 chr2:10749441 C/T cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.04 0.3 8.47e-7 Menopause (age at onset); CESC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC trans rs1545843 0.593 rs9669281 chr12:84791458 C/T cg03015433 chr16:56623111 MT3 -0.33 -6.01 -0.35 6.11e-9 Major depressive disorder; CESC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg11890956 chr21:40555474 PSMG1 1.11 17.6 0.73 1.91e-46 Cognitive function; CESC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg25036284 chr2:26402008 FAM59B -0.73 -8.35 -0.46 3.78e-15 Gut microbiome composition (summer); CESC trans rs10848704 0.525 rs4765709 chr12:2883637 C/T cg02057211 chr3:31803876 OSBPL10 -0.35 -6.22 -0.36 1.98e-9 Quantitative traits; CESC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg16145915 chr7:1198662 ZFAND2A -0.6 -9.21 -0.49 1.01e-17 Longevity;Endometriosis; CESC cis rs7212590 0.748 rs62081818 chr17:57890629 C/T cg20303301 chr17:57937339 TUBD1 -0.59 -5.56 -0.32 6.49e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg05863683 chr7:1912471 MAD1L1 0.37 5.52 0.32 8.19e-8 Bipolar disorder and schizophrenia; CESC trans rs11098499 0.657 rs9996569 chr4:120299004 G/C cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs796364 0.813 rs7565417 chr2:201057491 G/A cg23649088 chr2:200775458 C2orf69 0.51 5.24 0.31 3.21e-7 Schizophrenia; CESC cis rs7843479 0.562 rs6988010 chr8:21859084 G/A cg17168535 chr8:21777572 XPO7 0.73 11.4 0.57 9.24e-25 Mean corpuscular volume; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg25706861 chr2:220404357 CHPF 0.44 6.07 0.35 4.37e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4835473 0.801 rs999049 chr4:144636593 T/C cg25736465 chr4:144833511 NA -0.45 -6.81 -0.39 6.71e-11 Immature fraction of reticulocytes; CESC cis rs1401999 1.000 rs1402002 chr3:183642794 A/G cg01324343 chr3:183735012 ABCC5 0.63 13.49 0.64 6.17e-32 Anterior chamber depth; CESC cis rs2073300 1.000 rs17830565 chr20:23444805 G/A cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs67311347 0.955 rs60554147 chr3:40472503 T/C cg01475735 chr3:40494733 NA -0.4 -5.06 -0.3 8.01e-7 Renal cell carcinoma; CESC cis rs7429990 0.965 rs7627645 chr3:48093133 A/T cg11946769 chr3:48343235 NME6 -0.44 -5.37 -0.31 1.69e-7 Educational attainment (years of education); CESC cis rs4319547 0.915 rs3803005 chr12:123110654 T/C cg05707623 chr12:122985044 ZCCHC8 -0.59 -7.04 -0.4 1.69e-11 Body mass index; CESC cis rs3733585 0.673 rs4467563 chr4:9953460 A/T cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1355223 0.902 rs34751755 chr11:34694243 C/T cg11058730 chr11:34937778 PDHX;APIP -0.46 -5.97 -0.34 7.73e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9790314 0.905 rs7633186 chr3:161003124 A/G cg04691961 chr3:161091175 C3orf57 -0.41 -5.34 -0.31 2e-7 Morning vs. evening chronotype; CESC cis rs4523957 0.893 rs11078018 chr17:2162119 A/G cg16513277 chr17:2031491 SMG6 -0.6 -8.18 -0.45 1.22e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4843747 0.671 rs8062855 chr16:88106941 T/C cg17633681 chr16:88106987 BANP 0.76 10.51 0.54 8.01e-22 Menopause (age at onset); CESC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg10862848 chr6:42927986 GNMT 0.26 6.77 0.38 8.38e-11 Alzheimer's disease in APOE e4+ carriers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07996992 chr1:85040343 CTBS 0.65 7.87 0.44 9.03e-14 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11843188 chr11:102322558 TMEM123 -0.45 -6.27 -0.36 1.49e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6933660 0.800 rs3800273 chr6:151759035 G/C cg14262678 chr6:151773367 RMND1;C6orf211 0.67 9.63 0.51 5.06e-19 Menarche (age at onset); CESC cis rs34734847 0.842 rs556001 chr12:121152967 A/G cg21892295 chr12:121157589 UNC119B -0.4 -6.43 -0.37 5.96e-10 Mean corpuscular volume; CESC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.31 -0.31 2.34e-7 Life satisfaction; CESC cis rs7584330 0.554 rs11892169 chr2:238432809 G/A cg14458575 chr2:238380390 NA 0.48 5.31 0.31 2.37e-7 Prostate cancer; CESC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg26314531 chr2:26401878 FAM59B -0.77 -8.56 -0.47 9.38e-16 Gut microbiome composition (summer); CESC cis rs2880765 0.835 rs900573 chr15:86037993 G/T cg19183879 chr15:85880815 NA 0.25 5.11 0.3 6.1e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25292628 chr9:6758853 KDM4C -0.58 -6.71 -0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs10832963 0.924 rs10500834 chr11:18638712 A/T cg09201001 chr11:18656081 SPTY2D1 0.82 12.36 0.6 5.21e-28 Breast cancer; CESC cis rs7264396 0.635 rs3827030 chr20:34474947 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.85 10.99 0.56 2.06e-23 Total cholesterol levels; CESC cis rs3126085 0.877 rs7543541 chr1:152230878 T/C cg03465714 chr1:152285911 FLG -0.44 -5.52 -0.32 8.23e-8 Atopic dermatitis; CESC cis rs7772486 0.875 rs6938972 chr6:146410608 G/A cg23711669 chr6:146136114 FBXO30 0.86 12.72 0.62 2.98e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs17253792 0.822 rs78323463 chr14:56045451 T/G cg24579896 chr14:56047964 C14orf33;KTN1 0.85 5.74 0.33 2.53e-8 Putamen volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13468249 chr17:7154818 DULLARD;C17orf81 -0.44 -6.14 -0.35 3.06e-9 Ulcerative colitis; CESC cis rs9467711 0.591 rs17586553 chr6:25928775 C/T cg08501292 chr6:25962987 TRIM38 0.83 8.12 0.45 1.73e-14 Autism spectrum disorder or schizophrenia; CESC cis rs7084402 0.967 rs7098326 chr10:60276906 C/T cg07615347 chr10:60278583 BICC1 -0.59 -9.42 -0.5 2.24e-18 Refractive error; CESC cis rs568617 0.903 rs601863 chr11:65646557 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.69 -7.4 -0.41 1.81e-12 Crohn's disease; CESC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg06108461 chr20:60628389 TAF4 0.83 11.48 0.58 4.88e-25 Body mass index; CESC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg14393609 chr7:65229607 NA 0.48 6.47 0.37 4.72e-10 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27343303 chr11:34380546 NA -0.46 -6.8 -0.39 7.07e-11 Gambling; CESC cis rs3733585 0.673 rs7376505 chr4:9952744 C/A cg11266682 chr4:10021025 SLC2A9 -0.57 -10.99 -0.56 2.07e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg18765753 chr7:1198926 ZFAND2A -0.45 -6.65 -0.38 1.65e-10 Longevity;Endometriosis; CESC cis rs11122272 0.735 rs2808591 chr1:231523421 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.74 -8.58 -0.47 7.96e-16 Gut microbiome composition (summer); CESC cis rs4319547 1.000 rs10998 chr12:122989412 G/A cg23029597 chr12:123009494 RSRC2 -0.49 -5.35 -0.31 1.93e-7 Body mass index; CESC cis rs4595586 0.545 rs2388179 chr12:39364036 T/A cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC cis rs7552167 0.925 rs78312791 chr1:24513613 C/A cg01960748 chr1:24522592 NA 0.45 5.59 0.32 5.57e-8 Psoriasis vulgaris; CESC cis rs11760633 0.615 rs11767667 chr7:1840557 C/T cg23422044 chr7:1970798 MAD1L1 -0.48 -5.67 -0.33 3.67e-8 Coronary artery disease; CESC cis rs7923609 0.934 rs10761756 chr10:65172328 C/T cg01631684 chr10:65280961 REEP3 -0.43 -5.32 -0.31 2.25e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7089973 0.604 rs11196952 chr10:116607592 G/A cg23260525 chr10:116636907 FAM160B1 0.4 7.2 0.4 6.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs10883723 0.810 rs7917525 chr10:104246755 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.56 0.42 6.55e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs734999 0.545 rs3890745 chr1:2553624 C/T cg20673091 chr1:2541236 MMEL1 -0.47 -7.89 -0.44 8.09e-14 Ulcerative colitis; CESC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg01988459 chr11:68622903 NA -0.4 -5.3 -0.31 2.4e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4523957 0.854 rs404392 chr17:2191000 G/A cg16513277 chr17:2031491 SMG6 0.59 8.07 0.44 2.51e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs228437 1.000 rs985122 chr6:134931300 A/G cg24504307 chr6:134963096 NA 0.55 5.93 0.34 9.31e-9 Melanoma; CESC cis rs35849525 0.633 rs62263602 chr3:50152491 C/T cg24308560 chr3:49941425 MST1R -0.54 -6.41 -0.37 6.64e-10 Intelligence (multi-trait analysis); CESC cis rs6456156 0.586 rs9459853 chr6:167465774 C/A cg23791538 chr6:167370224 RNASET2 -0.52 -6.7 -0.38 1.23e-10 Primary biliary cholangitis; CESC cis rs7772486 0.875 rs1412081 chr6:146409733 A/G cg05347473 chr6:146136440 FBXO30 0.48 6.51 0.37 3.83e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7072216 0.763 rs6584204 chr10:100173580 C/G cg26618903 chr10:100175079 PYROXD2 -0.38 -5.87 -0.34 1.32e-8 Metabolite levels; CESC cis rs9815354 1.000 rs1717031 chr3:41905791 G/T cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg18876405 chr7:65276391 NA 0.46 6.19 0.36 2.27e-9 Aortic root size; CESC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg10691866 chr7:65817282 TPST1 0.34 5.61 0.33 5.03e-8 Aortic root size; CESC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.96 -0.34 8.09e-9 Parkinson's disease; CESC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg00166722 chr3:10149974 C3orf24 0.49 6.31 0.36 1.18e-9 Alzheimer's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18220030 chr1:110090737 GNAI3 -0.47 -6.79 -0.38 7.13e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs1945213 0.694 rs7116741 chr11:55862620 C/T cg15704280 chr7:45808275 SEPT13 0.76 7.34 0.41 2.57e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.18 0.3 4.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg22143856 chr6:28129313 ZNF389 0.45 5.78 0.33 2.12e-8 Parkinson's disease; CESC cis rs17253792 0.822 rs77761669 chr14:56034216 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.87 0.34 1.27e-8 Putamen volume; CESC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg26314531 chr2:26401878 FAM59B -0.76 -8.49 -0.46 1.47e-15 Gut microbiome composition (summer); CESC cis rs10129255 0.556 rs9324093 chr14:107139910 C/T cg07958169 chr14:107095056 NA -0.45 -6.75 -0.38 9.52e-11 Kawasaki disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02262025 chr16:75657287 ADAT1 -0.48 -6.26 -0.36 1.57e-9 Ulcerative colitis; CESC cis rs11677416 1.000 rs6542093 chr2:113528536 G/A cg27083787 chr2:113543245 IL1A 0.41 5.16 0.3 4.75e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs6543140 0.964 rs62154972 chr2:103048738 G/A cg04239558 chr2:103089729 SLC9A4 0.48 6.04 0.35 5.06e-9 Blood protein levels; CESC cis rs35079168 0.923 rs12115573 chr9:137288782 G/A cg00753924 chr9:137298813 RXRA -0.36 -5.52 -0.32 7.94e-8 Intelligence; CESC cis rs7264396 0.790 rs6121026 chr20:34266883 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.88 -0.59 2.18e-26 Total cholesterol levels; CESC cis rs1401999 1.000 rs6443927 chr3:183718864 A/G cg01324343 chr3:183735012 ABCC5 0.65 13.75 0.65 8.04e-33 Anterior chamber depth; CESC cis rs77972916 0.561 rs13411629 chr2:43566990 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.58 -5.11 -0.3 6.3e-7 Granulocyte percentage of myeloid white cells; CESC cis rs9894429 1.000 rs11652797 chr17:79574124 A/G cg18240062 chr17:79603768 NPLOC4 0.72 10.3 0.53 3.89e-21 Eye color traits; CESC cis rs6963495 0.818 rs17343556 chr7:105151272 C/T cg02135003 chr7:105160482 PUS7 -0.47 -5.63 -0.33 4.47e-8 Bipolar disorder (body mass index interaction); CESC cis rs863345 0.535 rs12068285 chr1:158499632 G/A cg12129480 chr1:158549410 OR10X1 -0.32 -6.15 -0.35 2.82e-9 Pneumococcal bacteremia; CESC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.83 10.53 0.54 7.1e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4974559 1.000 rs4974559 chr4:1380848 C/T cg20887711 chr4:1340912 KIAA1530 -0.45 -5.37 -0.31 1.76e-7 Systolic blood pressure; CESC cis rs11252926 0.528 rs11252090 chr10:436547 C/T cg18196295 chr10:418757 DIP2C -0.55 -7.6 -0.42 5.07e-13 Psychosis in Alzheimer's disease; CESC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4604732 0.642 rs10925047 chr1:247640143 A/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.4 5.89 0.34 1.19e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6691722 0.503 rs3765431 chr1:24706410 T/C cg18323236 chr1:24743029 NIPAL3 0.37 5.61 0.33 5.09e-8 Response to interferon beta in multiple sclerosis; CESC cis rs4481887 0.927 rs10749646 chr1:248429719 A/G cg00666640 chr1:248458726 OR2T12 -0.4 -6.93 -0.39 3.15e-11 Common traits (Other); CESC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg11764359 chr7:65958608 NA 0.96 15.25 0.68 3.95e-38 Aortic root size; CESC cis rs8005677 0.962 rs34917191 chr14:23387628 T/C cg01529538 chr14:23388837 RBM23 0.51 6.87 0.39 4.64e-11 Cognitive ability (multi-trait analysis); CESC cis rs2952156 0.959 rs2952151 chr17:37828496 T/C cg07936489 chr17:37558343 FBXL20 -0.53 -6.33 -0.36 1.07e-9 Asthma; CESC cis rs1062177 1.000 rs12518722 chr5:151231460 A/G cg12924095 chr5:151150029 G3BP1 0.49 6.42 0.37 6.23e-10 Preschool internalizing problems; CESC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.8 -11.18 -0.57 4.95e-24 Prudent dietary pattern; CESC cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg09658497 chr7:2847517 GNA12 -0.43 -6.86 -0.39 4.85e-11 Height; CESC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg04166393 chr7:2884313 GNA12 0.59 7.63 0.42 4.18e-13 Height; CESC cis rs425277 1.000 rs262647 chr1:2095699 C/T cg24578937 chr1:2090814 PRKCZ 0.55 9.67 0.51 3.78e-19 Height; CESC cis rs2180341 0.855 rs4308584 chr6:127714874 A/G cg24812749 chr6:127587940 RNF146 0.81 11.3 0.57 1.96e-24 Breast cancer; CESC cis rs7208859 0.623 rs73269916 chr17:29096326 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.36 0.36 8.68e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs208520 0.837 rs208509 chr6:66941706 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.8 -9.45 -0.5 1.91e-18 Exhaled nitric oxide output; CESC cis rs7914558 1.000 rs11191542 chr10:104824324 T/A cg15744005 chr10:104629667 AS3MT -0.34 -5.58 -0.32 5.99e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg18876405 chr7:65276391 NA -0.52 -7.37 -0.41 2.11e-12 Aortic root size; CESC cis rs7100689 0.646 rs10466235 chr10:82149655 C/T cg00277334 chr10:82204260 NA 0.47 6.57 0.37 2.63e-10 Post bronchodilator FEV1; CESC cis rs2797160 1.000 rs78602343 chr6:126019768 T/C cg05901451 chr6:126070800 HEY2 0.46 6.54 0.37 3.08e-10 Endometrial cancer; CESC cis rs61931739 0.500 rs4436630 chr12:34394200 C/T cg23762105 chr12:34175262 ALG10 -0.39 -5.14 -0.3 5.26e-7 Morning vs. evening chronotype; CESC cis rs6580649 0.941 rs7959755 chr12:48446318 T/A cg05342945 chr12:48394962 COL2A1 0.5 5.85 0.34 1.47e-8 Lung cancer; CESC cis rs763014 0.898 rs35666389 chr16:629458 A/G cg00908189 chr16:619842 PIGQ 0.67 9.38 0.5 3.07e-18 Height; CESC trans rs11039798 0.557 rs4441015 chr11:49027070 A/G cg03929089 chr4:120376271 NA 0.62 6.14 0.35 2.96e-9 Axial length; CESC cis rs9393777 0.546 rs9366673 chr6:26893329 C/G cg12292205 chr6:26970375 C6orf41 -0.63 -7.3 -0.41 3.46e-12 Intelligence (multi-trait analysis); CESC trans rs61931739 0.500 rs28624237 chr12:34457171 G/T cg26384229 chr12:38710491 ALG10B 0.69 10.44 0.54 1.34e-21 Morning vs. evening chronotype; CESC cis rs2522056 0.808 rs17771891 chr5:131744202 A/G cg24060327 chr5:131705240 SLC22A5 -0.66 -7.14 -0.4 8.97e-12 Lymphocyte counts;Fibrinogen; CESC cis rs9929218 0.953 rs3114411 chr16:68734591 G/T cg02972257 chr16:68554789 NA -0.57 -6.67 -0.38 1.47e-10 Colorectal cancer; CESC cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg17372223 chr3:52568218 NT5DC2 0.36 5.07 0.3 7.49e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs7937682 0.575 rs11604704 chr11:111764396 G/A cg22437258 chr11:111473054 SIK2 -0.48 -5.3 -0.31 2.39e-7 Primary sclerosing cholangitis; CESC cis rs9910055 0.659 rs112114764 chr17:42201041 G/T cg08499158 chr17:42289980 UBTF 0.5 6.33 0.36 1.07e-9 Total body bone mineral density; CESC cis rs12586317 0.511 rs11540758 chr14:35498485 C/T cg16230307 chr14:35515116 FAM177A1 0.99 10.61 0.55 3.72e-22 Psoriasis; CESC cis rs9430161 0.579 rs7542164 chr1:11040223 G/A cg27631724 chr1:11040367 C1orf127 0.44 7.63 0.42 4.18e-13 Ewing sarcoma; CESC cis rs11677416 1.000 rs61381693 chr2:113525912 C/A cg27083787 chr2:113543245 IL1A 0.59 7.36 0.41 2.33e-12 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs7927771 0.524 rs7114813 chr11:47801101 A/G cg18512352 chr11:47633146 NA 0.33 5.17 0.3 4.51e-7 Subjective well-being; CESC cis rs9796 0.621 rs691702 chr15:41474399 C/G cg20272979 chr15:41787780 ITPKA 0.33 5.07 0.3 7.6e-7 Menopause (age at onset); CESC cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg05340658 chr4:99064831 C4orf37 0.76 11.13 0.56 7.59e-24 Colonoscopy-negative controls vs population controls; CESC cis rs4727027 0.865 rs62505077 chr7:148849656 T/A cg23158103 chr7:148848205 ZNF398 -0.42 -6.94 -0.39 3.1e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.15 0.3 5.1e-7 Life satisfaction; CESC cis rs4423214 1.000 rs4944957 chr11:71168035 C/T cg05163923 chr11:71159392 DHCR7 -0.76 -10.07 -0.53 2.02e-20 Vitamin D levels; CESC cis rs2625529 0.938 rs2625530 chr15:72126034 G/A cg16672083 chr15:72433130 SENP8 -0.42 -5.29 -0.31 2.54e-7 Red blood cell count; CESC trans rs11098499 0.908 rs9995234 chr4:120321827 A/G cg25214090 chr10:38739885 LOC399744 0.71 9.49 0.5 1.41e-18 Corneal astigmatism; CESC cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg18180107 chr4:99064573 C4orf37 0.39 5.1 0.3 6.45e-7 Colonoscopy-negative controls vs population controls; CESC cis rs728616 0.867 rs12412257 chr10:81729603 C/T cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs60154123 0.505 rs76426571 chr1:210041634 C/T cg25204440 chr1:209979598 IRF6 0.67 6.11 0.35 3.54e-9 Coronary artery disease; CESC cis rs12971120 0.891 rs12605820 chr18:72167802 G/A cg26446133 chr18:72167187 CNDP2 -0.76 -9.63 -0.51 5.13e-19 Refractive error; CESC cis rs13315871 0.858 rs13090428 chr3:58314412 A/G cg20936604 chr3:58311152 NA -0.51 -5.17 -0.3 4.65e-7 Cholesterol, total; CESC cis rs9815354 1.000 rs1564716 chr3:41862613 A/G cg03022575 chr3:42003672 ULK4 0.48 5.38 0.31 1.68e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg19077165 chr18:44547161 KATNAL2 -0.52 -7.63 -0.42 4.14e-13 Personality dimensions; CESC cis rs933688 0.526 rs9293565 chr5:90609736 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.62 7.19 0.4 6.76e-12 Smoking behavior; CESC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg23161317 chr6:28129485 ZNF389 0.4 5.69 0.33 3.29e-8 Cardiac Troponin-T levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25307277 chr6:26124601 HIST1H2AC;HIST1H2BC 0.52 6.12 0.35 3.34e-9 Gut microbiome composition (summer); CESC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg04944784 chr2:26401820 FAM59B -0.92 -10.23 -0.53 6.32e-21 Gut microbiome composition (summer); CESC cis rs2120019 0.938 rs5020842 chr15:75322310 T/C cg17294928 chr15:75287854 SCAMP5 -0.8 -9.5 -0.5 1.29e-18 Blood trace element (Zn levels); CESC cis rs9291683 0.588 rs6857693 chr4:10018435 G/A cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.14e-46 Bone mineral density; CESC trans rs11601239 0.593 rs1954761 chr11:105596885 T/C cg15315312 chr2:176867285 KIAA1715 -0.47 -6.3 -0.36 1.25e-9 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25910466 chr20:21283998 XRN2 0.57 6.17 0.35 2.54e-9 Gut microbiome composition (summer); CESC trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg15704280 chr7:45808275 SEPT13 -0.95 -16.87 -0.72 7.12e-44 Coronary artery disease; CESC cis rs2573652 0.698 rs12916269 chr15:100530216 A/T cg09918751 chr15:100517450 ADAMTS17 0.33 6.08 0.35 4.28e-9 Height; CESC cis rs6815814 1.000 rs11722836 chr4:38811529 T/A cg02016764 chr4:38805732 TLR1 -0.62 -7.43 -0.42 1.5e-12 Breast cancer; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg02955369 chr1:173837185 SNORD76;SNORD74;SNORD75;GAS5;ZBTB37 -0.51 -6.63 -0.38 1.9e-10 Height; CESC cis rs7809950 0.678 rs17154040 chr7:107005246 C/T cg23024343 chr7:107201750 COG5 0.54 7.01 0.4 1.99e-11 Coronary artery disease; CESC cis rs7192380 0.639 rs7186296 chr16:69808998 A/G cg00738113 chr16:70207722 CLEC18C 0.32 5.26 0.31 3.04e-7 Sjögren's syndrome; CESC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.83 0.34 1.59e-8 Bipolar disorder; CESC trans rs116095464 0.558 rs6555052 chr5:224268 G/A cg00938859 chr5:1591904 SDHAP3 0.61 6.78 0.38 7.58e-11 Breast cancer; CESC cis rs7937682 0.883 rs553632 chr11:111462897 C/T cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC cis rs2191566 0.576 rs419839 chr19:44495598 C/T cg20607764 chr19:44506953 ZNF230 0.45 5.69 0.33 3.38e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs12220238 1.000 rs3812638 chr10:75896072 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.65 5.84 0.34 1.49e-8 Soluble interleukin-2 receptor subunit alpha; CESC cis rs3793917 0.901 rs36212732 chr10:124215198 A/G cg24884230 chr10:124216658 ARMS2 0.31 5.15 0.3 5.08e-7 Age-related macular degeneration; CESC cis rs6991838 0.584 rs6997959 chr8:66540482 T/C cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs1018836 0.631 rs61276517 chr8:91474406 A/G cg16814680 chr8:91681699 NA -0.55 -7.3 -0.41 3.26e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 6.09 0.35 3.9e-9 Electroencephalogram traits; CESC cis rs3762637 0.941 rs79493664 chr3:122109546 T/A cg24169773 chr3:122142474 KPNA1 -0.53 -6.13 -0.35 3.13e-9 LDL cholesterol levels; CESC trans rs11088226 0.681 rs2833897 chr21:33931792 T/C cg09050820 chr6:167586206 TCP10L2 0.82 7.68 0.43 3.12e-13 Gastritis; CESC cis rs7927771 1.000 rs10838748 chr11:47716381 T/G cg05585544 chr11:47624801 NA -0.5 -7.84 -0.43 1.14e-13 Subjective well-being; CESC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg06456125 chr7:65229604 NA 0.39 5.05 0.3 8.06e-7 Aortic root size; CESC cis rs4132509 0.947 rs320339 chr1:243870910 G/T cg21452805 chr1:244014465 NA 0.42 5.19 0.3 4.1e-7 RR interval (heart rate); CESC cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg22431228 chr1:16359049 CLCNKA 0.46 7.84 0.43 1.1e-13 Dilated cardiomyopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00543632 chr16:19098067 NA -0.62 -7.41 -0.41 1.67e-12 Gut microbiome composition (summer); CESC cis rs2882667 0.788 rs11959691 chr5:138481088 C/T cg04439458 chr5:138467593 SIL1 -0.38 -5.66 -0.33 3.95e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs17601876 0.814 rs11636639 chr15:51563092 T/G cg19946085 chr15:51559439 CYP19A1 -0.33 -5.38 -0.31 1.64e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs524281 0.817 rs7115081 chr11:65853541 A/G cg14036092 chr11:66035641 RAB1B -0.62 -6.39 -0.37 7.55e-10 Electroencephalogram traits; CESC cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg20503657 chr10:835505 NA -0.74 -7.9 -0.44 7.56e-14 Eosinophil percentage of granulocytes; CESC cis rs7208859 0.623 rs216436 chr17:28922900 G/A cg13385521 chr17:29058706 SUZ12P 0.73 5.32 0.31 2.23e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3820068 0.581 rs72645881 chr1:15928203 C/T cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs208520 0.690 rs10455194 chr6:66743356 A/G cg07460842 chr6:66804631 NA 0.97 12.84 0.62 1.11e-29 Exhaled nitric oxide output; CESC cis rs2380220 0.606 rs9488080 chr6:96006973 A/G cg23517279 chr6:96025343 MANEA 0.52 5.65 0.33 4.17e-8 Behavioural disinhibition (generation interaction); CESC cis rs3793683 0.825 rs3793674 chr10:134555773 C/T cg27286337 chr10:134555280 INPP5A -0.91 -14.42 -0.66 3.47e-35 Migraine; CESC trans rs3942852 0.774 rs10838812 chr11:48186924 T/C cg03929089 chr4:120376271 NA -0.65 -7.1 -0.4 1.15e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs3781663 0.581 rs10793018 chr11:70004396 G/A cg06393558 chr11:69982916 ANO1 -0.34 -5.86 -0.34 1.39e-8 Survival in rectal cancer; CESC cis rs2439831 0.867 rs3213991 chr15:43670280 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.92 11.23 0.57 3.34e-24 Lung cancer in ever smokers; CESC cis rs2635047 0.638 rs55730206 chr18:44608230 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.13 0.35 3.18e-9 Educational attainment; CESC cis rs796364 0.760 rs56225698 chr2:200910653 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.09e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg00376283 chr12:123451042 ABCB9 0.73 10.1 0.53 1.68e-20 Platelet count; CESC cis rs5758511 0.680 rs5758652 chr22:42612408 T/C cg00645731 chr22:42541494 CYP2D7P1 0.59 8.71 0.47 3.36e-16 Birth weight; CESC cis rs870825 0.616 rs67409049 chr4:185623989 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs10045504 0.502 rs17456635 chr5:38745456 G/A cg15396434 chr5:38725168 NA -0.73 -6.82 -0.39 6.32e-11 Night sleep phenotypes; CESC cis rs9556958 0.708 rs9513435 chr13:99160334 C/G cg20750642 chr13:99100586 FARP1 0.37 5.98 0.34 7.19e-9 Educational attainment (years of education); CESC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg07507251 chr3:52567010 NT5DC2 0.41 7.11 0.4 1.05e-11 Bipolar disorder; CESC cis rs7512552 0.780 rs55823828 chr1:150467296 G/C cg15654264 chr1:150340011 RPRD2 0.39 5.15 0.3 5.07e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg19346786 chr7:2764209 NA -0.52 -7.23 -0.41 5.12e-12 Height; CESC trans rs7246760 0.867 rs10410379 chr19:9902197 G/A cg02900749 chr2:68251473 NA -0.74 -6.81 -0.39 6.68e-11 Pursuit maintenance gain; CESC cis rs10896135 0.526 rs484262 chr11:66399681 C/T cg15964523 chr11:66469143 SPTBN2 0.41 5.43 0.32 1.29e-7 Bipolar disorder; CESC cis rs6964587 0.934 rs4512319 chr7:91733829 G/A cg17063962 chr7:91808500 NA 0.47 5.72 0.33 2.82e-8 Breast cancer; CESC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg19592336 chr6:28129416 ZNF389 0.62 8.12 0.45 1.77e-14 Parkinson's disease; CESC cis rs1559088 0.948 rs12608825 chr19:33581219 C/T cg27124370 chr19:33622961 WDR88 -0.48 -6.29 -0.36 1.27e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2594989 0.943 rs2606748 chr3:11373989 T/C cg00170343 chr3:11313890 ATG7 0.56 5.11 0.3 6.27e-7 Circulating chemerin levels; CESC cis rs637571 0.544 rs617791 chr11:65702523 C/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 5.89 0.34 1.2e-8 Eosinophil percentage of white cells; CESC cis rs9911578 1.000 rs2270097 chr17:56572070 G/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.42 -5.69 -0.33 3.29e-8 Intelligence (multi-trait analysis); CESC cis rs8014204 0.544 rs2286913 chr14:75386576 G/A cg11812906 chr14:75593930 NEK9 0.54 6.59 0.38 2.31e-10 Caffeine consumption; CESC cis rs7937682 1.000 rs11213973 chr11:111538903 A/T cg22437258 chr11:111473054 SIK2 0.68 9.07 0.49 2.8e-17 Primary sclerosing cholangitis; CESC cis rs16895831 0.549 rs12198323 chr6:42611872 A/G cg10605015 chr6:42532144 UBR2 -0.5 -5.52 -0.32 8.27e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs1559088 0.847 rs8110181 chr19:33605939 G/A cg17764715 chr19:33622953 WDR88 0.46 5.94 0.34 8.75e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs12541635 0.677 rs13439705 chr8:106967268 T/C cg10147462 chr8:107024639 NA 0.43 6.32 0.36 1.08e-9 Age of smoking initiation; CESC trans rs4740619 0.556 rs2987010 chr9:15966278 C/G cg02108068 chr19:56826442 NA -0.44 -6.35 -0.36 9.18e-10 Body mass index; CESC cis rs1144333 1.000 rs5745343 chr1:76273805 A/G cg22875332 chr1:76189707 ACADM -0.57 -6.05 -0.35 4.96e-9 Attention function in attention deficit hyperactive disorder; CESC cis rs2228479 0.702 rs17233441 chr16:89817998 C/G cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs826838 1.000 rs12366971 chr12:38737687 T/G cg13010199 chr12:38710504 ALG10B 0.61 8.81 0.48 1.68e-16 Heart rate; CESC cis rs17376456 0.569 rs10057664 chr5:93182274 C/T cg21475434 chr5:93447410 FAM172A -0.5 -5.14 -0.3 5.34e-7 Diabetic retinopathy; CESC cis rs8005677 0.828 rs12437151 chr14:23372913 G/A cg01529538 chr14:23388837 RBM23 0.42 5.57 0.32 6.3e-8 Cognitive ability (multi-trait analysis); CESC cis rs67311347 0.955 rs9821036 chr3:40379007 A/G cg09455208 chr3:40491958 NA 0.48 8.34 0.46 4.1e-15 Renal cell carcinoma; CESC cis rs15300 0.661 rs9505461 chr6:8495128 C/G cg07606381 chr6:8435919 SLC35B3 0.89 5.44 0.32 1.23e-7 Pursuit maintenance gain; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg06178104 chr17:43246560 HEXIM2 0.45 6.19 0.36 2.34e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3820068 0.581 rs111699992 chr1:15927158 G/A cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.93 0.44 6.13e-14 Bipolar disorder; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg19507727 chr1:233086292 C1orf57 0.49 6.08 0.35 4.25e-9 Bronchopulmonary dysplasia; CESC cis rs8062405 0.723 rs4788079 chr16:28559363 C/A cg01378222 chr16:28622494 SULT1A1 0.31 5.16 0.3 4.87e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg16680214 chr1:154839983 KCNN3 -0.44 -6.69 -0.38 1.28e-10 Prostate cancer; CESC cis rs7618501 0.902 rs7645061 chr3:49868842 C/T cg24308560 chr3:49941425 MST1R -0.52 -6.97 -0.39 2.55e-11 Intelligence (multi-trait analysis); CESC cis rs6831352 0.879 rs1230154 chr4:99988659 C/T cg12011299 chr4:100065546 ADH4 0.62 7.95 0.44 5.44e-14 Alcohol dependence; CESC cis rs3733585 0.736 rs4543113 chr4:10008305 G/A cg00071950 chr4:10020882 SLC2A9 0.79 12.78 0.62 1.78e-29 Cleft plate (environmental tobacco smoke interaction); CESC cis rs17253792 0.822 rs79538158 chr14:56051365 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.66 0.33 3.95e-8 Putamen volume; CESC cis rs1577917 1.000 rs955196 chr6:86729951 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.4 5.04 0.3 8.45e-7 Response to antipsychotic treatment; CESC cis rs9527 0.545 rs12247514 chr10:104958066 C/A cg04362960 chr10:104952993 NT5C2 0.43 5.44 0.32 1.2e-7 Arsenic metabolism; CESC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg25767906 chr1:53392781 SCP2 0.44 6.13 0.35 3.09e-9 Monocyte count; CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 6.73 0.38 1.07e-10 Bipolar disorder; CESC cis rs9487051 0.652 rs6568559 chr6:109592751 C/T cg21918786 chr6:109611834 NA -0.37 -5.41 -0.32 1.39e-7 Reticulocyte fraction of red cells; CESC cis rs2842992 0.714 rs2475564 chr6:160123673 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.12 0.49 2e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg05368731 chr17:41323189 NBR1 0.59 8.38 0.46 3.14e-15 Menopause (age at onset); CESC cis rs13102973 0.932 rs4130840 chr4:135869598 T/G cg14419869 chr4:135874104 NA -0.4 -6.29 -0.36 1.32e-9 Subjective well-being; CESC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg12963246 chr6:28129442 ZNF389 0.53 6.91 0.39 3.61e-11 Parkinson's disease; CESC cis rs72781680 0.898 rs72782126 chr2:24039901 A/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs751837 0.591 rs8007077 chr14:103413454 T/C cg10087771 chr14:103399429 CDC42BPB 0.72 6.21 0.36 2.06e-9 Large B-cell lymphoma; CESC cis rs2559856 1.000 rs2559860 chr12:102087636 C/T cg15068132 chr12:102092402 CHPT1 -0.39 -5.19 -0.3 4.21e-7 Blood protein levels; CESC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg08027265 chr7:2291960 NA -0.34 -5.13 -0.3 5.48e-7 Bipolar disorder and schizophrenia; CESC cis rs7191439 0.728 rs4238687 chr16:88788903 T/G cg27087555 chr16:88793112 FAM38A -1.43 -12.29 -0.6 9.2e-28 Plateletcrit; CESC cis rs6815814 0.847 rs11725309 chr4:38783848 T/C cg02016764 chr4:38805732 TLR1 -0.69 -8.4 -0.46 2.75e-15 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07870854 chr16:791252 NARFL -0.48 -6.49 -0.37 4.13e-10 Fibrinogen levels; CESC cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9399137 0.507 rs56164974 chr6:135288716 C/T cg22676075 chr6:135203613 NA 0.54 7.12 0.4 9.9e-12 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs854765 0.583 rs11871899 chr17:17826748 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.53 7.31 0.41 3.19e-12 Total body bone mineral density; CESC cis rs11098499 0.955 rs6815725 chr4:120158410 C/A cg09307838 chr4:120376055 NA 0.87 11.52 0.58 3.6e-25 Corneal astigmatism; CESC cis rs1775715 0.737 rs2799012 chr10:32103077 C/T cg18675610 chr10:32216311 ARHGAP12 0.34 5.27 0.31 2.85e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7107174 1.000 rs10793309 chr11:78093799 G/A cg02023728 chr11:77925099 USP35 0.38 5.2 0.3 3.96e-7 Testicular germ cell tumor; CESC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg04166393 chr7:2884313 GNA12 0.61 8.24 0.45 8.02e-15 Height; CESC cis rs67478160 0.643 rs12880167 chr14:104300829 C/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.16 -0.4 8.15e-12 Schizophrenia; CESC trans rs10776614 0.799 rs7085183 chr10:49764029 G/C cg19218067 chr2:181235115 NA 0.5 6.1 0.35 3.7e-9 Self-employment; CESC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs4629710 0.592 rs11759926 chr6:131571269 G/T cg12606694 chr6:131520996 AKAP7 0.5 6.05 0.35 4.84e-9 Multiple myeloma (IgH translocation); CESC cis rs7259376 0.902 rs10414591 chr19:22600122 G/A cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.79e-7 Menopause (age at onset); CESC cis rs4853012 0.941 rs7571083 chr2:74342260 C/G cg05890377 chr2:74357713 NA 0.59 7.22 0.41 5.5e-12 Gestational age at birth (maternal effect); CESC trans rs561341 0.941 rs17780086 chr17:30343282 G/A cg20587970 chr11:113659929 NA -1.5 -18.59 -0.75 5.81e-50 Hip circumference adjusted for BMI; CESC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg25036284 chr2:26402008 FAM59B -0.59 -6.76 -0.38 8.61e-11 Gut microbiome composition (summer); CESC cis rs748404 0.646 rs2253268 chr15:43800968 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.84 0.43 1.11e-13 Lung cancer; CESC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg00166722 chr3:10149974 C3orf24 0.53 6.19 0.36 2.32e-9 Alzheimer's disease; CESC cis rs12900413 0.687 rs10152954 chr15:90307442 T/C cg24249390 chr15:90295951 MESP1 -0.41 -5.65 -0.33 4.04e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs6460942 0.597 rs4719315 chr7:12528634 A/G cg10578991 chr7:12443926 VWDE -0.49 -5.08 -0.3 7.1e-7 Coronary artery disease; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg12788078 chr18:43546845 KIAA1632 -0.51 -6.75 -0.38 9.36e-11 Height; CESC cis rs7116495 1.000 rs7937582 chr11:71744613 C/T cg10381502 chr11:71823885 C11orf51 -0.65 -5.29 -0.31 2.62e-7 Severe influenza A (H1N1) infection; CESC cis rs6831352 0.918 rs6813415 chr4:100048509 T/C cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs10754283 0.870 rs2390764 chr1:90112827 T/G cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9486719 1.000 rs2064947 chr6:97052754 C/T cg06623918 chr6:96969491 KIAA0776 -0.83 -8.8 -0.48 1.81e-16 Migraine;Coronary artery disease; CESC cis rs4072980 0.545 rs10890285 chr1:38453576 A/C cg26528311 chr1:38462546 FHL3 -0.37 -5.67 -0.33 3.78e-8 Coronary artery disease; CESC cis rs2228479 0.850 rs62056103 chr16:89942781 G/A cg04013166 chr16:89971882 TCF25 0.75 6.39 0.37 7.38e-10 Skin colour saturation; CESC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06691214 chr2:208394839 CREB1 0.58 6.13 0.35 3.26e-9 Bipolar disorder and schizophrenia; CESC cis rs721399 0.614 rs4646246 chr8:18248661 A/G cg18736775 chr8:18248649 NAT2 -0.5 -5.3 -0.31 2.42e-7 Blood metabolite levels; CESC cis rs12681288 0.862 rs7814231 chr8:1021103 A/G cg04851639 chr8:1020857 NA -0.38 -8.57 -0.47 8.49e-16 Schizophrenia; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg06001652 chr11:2951578 PHLDA2 0.48 6.69 0.38 1.36e-10 Tetralogy of Fallot; CESC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg11890956 chr21:40555474 PSMG1 -0.6 -8.28 -0.45 6.25e-15 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04429812 chr17:37814043 STARD3 -0.57 -6.03 -0.35 5.36e-9 Gut microbiome composition (summer); CESC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg18876405 chr7:65276391 NA 0.46 6.09 0.35 3.86e-9 Aortic root size; CESC trans rs61931739 0.517 rs11053067 chr12:34191391 T/C cg26384229 chr12:38710491 ALG10B 0.65 9.11 0.49 2.1e-17 Morning vs. evening chronotype; CESC cis rs9815354 0.812 rs73073226 chr3:42005838 T/C cg03022575 chr3:42003672 ULK4 0.64 5.78 0.33 2.07e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs6500602 0.727 rs1477123 chr16:4560627 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.4 5.9 0.34 1.08e-8 Schizophrenia; CESC cis rs225245 0.817 rs12150359 chr17:34024584 C/T cg05299278 chr17:33885742 SLFN14 0.39 5.65 0.33 4.16e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs703842 1.000 rs6581155 chr12:58178162 A/G cg18357645 chr12:58087776 OS9 -0.38 -5.36 -0.31 1.82e-7 Multiple sclerosis; CESC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg22105103 chr4:187893119 NA 0.51 7.69 0.43 2.88e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs9549367 0.826 rs35306827 chr13:113869045 G/A cg18105134 chr13:113819100 PROZ -0.7 -8.83 -0.48 1.47e-16 Platelet distribution width; CESC cis rs8020095 0.528 rs2064489 chr14:67476497 C/G cg19548862 chr14:67692701 FAM71D -0.49 -6.09 -0.35 3.92e-9 Depression (quantitative trait); CESC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.6 7.59 0.42 5.31e-13 Tonsillectomy; CESC cis rs694739 0.628 rs538147 chr11:64129722 G/A cg23796481 chr11:64053134 BAD;GPR137 0.56 6.92 0.39 3.4e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs3820068 0.581 rs16849152 chr1:15921774 A/C cg17385448 chr1:15911702 AGMAT 0.41 6.58 0.37 2.54e-10 Systolic blood pressure; CESC cis rs56235845 0.694 rs11738681 chr5:176761535 A/G cg16006841 chr5:176797999 RGS14 0.46 5.78 0.33 2.09e-8 Hemoglobin concentration;Hematocrit; CESC cis rs1538970 1.000 rs1538970 chr1:45847562 G/A cg03146154 chr1:46216737 IPP 0.46 5.59 0.33 5.5e-8 Platelet count; CESC cis rs7727544 0.684 rs272893 chr5:131663062 T/C cg24060327 chr5:131705240 SLC22A5 -0.62 -8.06 -0.44 2.55e-14 Blood metabolite levels; CESC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.12 0.53 1.44e-20 Prudent dietary pattern; CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg04025307 chr7:1156635 C7orf50 0.45 6.15 0.35 2.8e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16668394 chr11:64578521 MEN1 -0.63 -7.6 -0.42 5.29e-13 Gut microbiome composition (summer); CESC cis rs4888262 0.526 rs12921903 chr16:74625575 C/T cg01733217 chr16:74700730 RFWD3 0.85 11.4 0.57 9.25e-25 Testicular germ cell tumor; CESC cis rs11098499 0.657 rs4463052 chr4:120313258 T/C cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs11190604 1.000 rs2295776 chr10:102295629 G/T cg07080220 chr10:102295463 HIF1AN 0.7 6.5 0.37 3.99e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg26839252 chr6:160211577 TCP1;MRPL18 0.44 5.03 0.3 9.06e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs2522056 0.935 rs757104 chr5:131795229 T/C cg24060327 chr5:131705240 SLC22A5 0.59 6.61 0.38 2.07e-10 Lymphocyte counts;Fibrinogen; CESC cis rs7084402 0.934 rs1649089 chr10:60289695 T/C cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC trans rs7980799 0.682 rs1601006 chr12:33629519 C/T cg26384229 chr12:38710491 ALG10B -0.6 -8.38 -0.46 3.05e-15 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg11644478 chr21:40555479 PSMG1 -0.53 -7.28 -0.41 3.78e-12 Menarche (age at onset); CESC cis rs11098499 0.708 rs10005237 chr4:120237897 T/C cg09307838 chr4:120376055 NA 0.79 10.77 0.55 1.17e-22 Corneal astigmatism; CESC cis rs9640161 0.830 rs3757425 chr7:150067640 A/C cg21361702 chr7:150065534 REPIN1 0.57 7.54 0.42 7.72e-13 Blood protein levels;Circulating chemerin levels; CESC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg24250549 chr1:154909240 PMVK 0.74 11.09 0.56 1.01e-23 Prostate cancer; CESC cis rs11190604 1.000 rs10883512 chr10:102308516 A/G cg07080220 chr10:102295463 HIF1AN 0.66 6.04 0.35 5.08e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg00166722 chr3:10149974 C3orf24 0.45 5.65 0.33 4.12e-8 Alzheimer's disease; CESC cis rs892961 0.932 rs12452788 chr17:75406866 T/C cg05865280 chr17:75406074 SEPT9 0.65 13.12 0.63 1.19e-30 Airflow obstruction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07052513 chr2:86668451 KDM3A 0.57 6.26 0.36 1.58e-9 Gut microbiome composition (summer); CESC cis rs11734570 0.581 rs4401459 chr4:38585268 G/T cg18361445 chr4:38666374 KLF3;FLJ13197 -0.62 -7.39 -0.41 1.94e-12 Inflammatory bowel disease;Crohn's disease; CESC cis rs1443512 0.812 rs4759058 chr12:54339052 C/A cg12374095 chr12:54320830 NA -0.44 -5.99 -0.35 6.65e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs7937682 0.961 rs17113227 chr11:111620491 A/G cg09085632 chr11:111637200 PPP2R1B -1.03 -15.9 -0.7 1.98e-40 Primary sclerosing cholangitis; CESC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg21782813 chr7:2030301 MAD1L1 0.51 7.09 0.4 1.23e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4253772 0.591 rs113101219 chr22:46659186 C/A cg10541313 chr22:46663664 TTC38 0.72 5.84 0.34 1.54e-8 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 0.871 rs10504226 chr8:58159283 A/G cg22535103 chr8:58192502 C8orf71 -0.92 -11.38 -0.57 1.11e-24 Developmental language disorder (linguistic errors); CESC cis rs3806843 1.000 rs10053586 chr5:140210760 T/C cg26395211 chr5:140044315 WDR55 -0.44 -5.5 -0.32 9.16e-8 Depressive symptoms (multi-trait analysis); CESC cis rs11098499 0.954 rs67265404 chr4:120359270 C/T cg09307838 chr4:120376055 NA 0.92 12.73 0.62 2.79e-29 Corneal astigmatism; CESC cis rs17253792 0.822 rs7150841 chr14:56088986 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs11864453 0.647 rs9941346 chr16:72135707 C/G cg16558253 chr16:72132732 DHX38 -0.54 -8.44 -0.46 2.04e-15 Fibrinogen levels; CESC cis rs6732160 0.774 rs11890053 chr2:73373448 G/A cg01422370 chr2:73384389 NA 0.43 7.45 0.42 1.31e-12 Intelligence (multi-trait analysis); CESC cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg05347473 chr6:146136440 FBXO30 0.75 9.54 0.51 9.85e-19 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22199410 chr12:51985016 SCN8A 0.52 6.42 0.37 6.22e-10 Gut microbiome composition (summer); CESC cis rs9560113 0.597 rs947170 chr13:112241062 G/A cg10483660 chr13:112241077 NA -0.45 -7.66 -0.43 3.6e-13 Menarche (age at onset); CESC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg03209412 chr4:183728196 NA 0.57 5.2 0.3 3.97e-7 Pediatric autoimmune diseases; CESC cis rs9660992 0.626 rs1172113 chr1:205226288 T/C cg21643547 chr1:205240462 TMCC2 -0.42 -6.05 -0.35 4.94e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg05234568 chr11:5960015 NA 0.73 11.53 0.58 3.47e-25 DNA methylation (variation); CESC cis rs34779708 0.966 rs4294520 chr10:35422506 C/T cg03585969 chr10:35415529 CREM 0.76 9.95 0.52 4.98e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs763121 0.853 rs138702 chr22:39132601 A/T cg06022373 chr22:39101656 GTPBP1 -0.93 -16.41 -0.71 3.14e-42 Menopause (age at onset); CESC cis rs1153858 1.000 rs56850226 chr15:45633118 T/C cg21132104 chr15:45694354 SPATA5L1 0.83 11.2 0.57 4.45e-24 Homoarginine levels; CESC cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC trans rs3780486 0.522 rs7029897 chr9:33124042 T/C cg20290983 chr6:43655470 MRPS18A 0.76 12.21 0.6 1.63e-27 IgG glycosylation; CESC trans rs11098499 0.779 rs7674500 chr4:120303593 C/T cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg00310523 chr12:86230176 RASSF9 0.33 5.29 0.31 2.53e-7 Major depressive disorder; CESC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg13206674 chr6:150067644 NUP43 0.46 6.67 0.38 1.46e-10 Lung cancer; CESC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg11764359 chr7:65958608 NA -0.78 -11.22 -0.57 3.73e-24 Aortic root size; CESC cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg18180107 chr4:99064573 C4orf37 -0.41 -5.18 -0.3 4.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs34779708 0.931 rs11593858 chr10:35381373 G/A cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs5769765 0.818 rs8140681 chr22:50292081 C/A cg26441486 chr22:50317300 CRELD2 0.39 5.37 0.31 1.76e-7 Schizophrenia; CESC cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg03467027 chr4:99064603 C4orf37 -0.47 -5.76 -0.33 2.35e-8 Colonoscopy-negative controls vs population controls; CESC cis rs17384381 0.953 rs11161599 chr1:85795965 A/G cg16011679 chr1:85725395 C1orf52 -0.77 -8.08 -0.44 2.31e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs1190552 0.739 rs1998421 chr14:102979644 C/T cg18135206 chr14:102964638 TECPR2 0.43 5.45 0.32 1.14e-7 Blood protein levels; CESC cis rs2718058 0.630 rs2722292 chr7:37824581 A/G cg24998770 chr7:37888106 TXNDC3 0.34 5.17 0.3 4.67e-7 Alzheimer's disease (late onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20818191 chr4:866154 GAK 0.53 7.12 0.4 1.03e-11 Fibrinogen levels; CESC cis rs11031096 0.678 rs4606468 chr11:4183643 G/T cg18678763 chr11:4115507 RRM1 -0.47 -6.52 -0.37 3.57e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7100689 0.646 rs9804233 chr10:82134667 T/C cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg22903471 chr2:27725779 GCKR -0.51 -7.16 -0.4 7.71e-12 Total body bone mineral density; CESC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.03 0.56 1.62e-23 Alzheimer's disease; CESC cis rs1008375 0.797 rs6843530 chr4:17593605 G/T cg16339924 chr4:17578868 LAP3 0.69 8.95 0.48 6.16e-17 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6424115 0.830 rs2501423 chr1:24199026 A/C cg10978503 chr1:24200527 CNR2 0.32 6.24 0.36 1.74e-9 Immature fraction of reticulocytes; CESC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg07701084 chr6:150067640 NUP43 0.46 6.25 0.36 1.64e-9 Lung cancer; CESC cis rs9911578 0.692 rs411988 chr17:56709034 G/A cg05425664 chr17:57184151 TRIM37 -0.4 -5.47 -0.32 1.05e-7 Intelligence (multi-trait analysis); CESC cis rs698833 0.892 rs1067363 chr2:44658401 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.97 0.34 7.62e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7539624 1.000 rs7539624 chr1:223906827 G/A cg10100437 chr1:223903862 CAPN2 -0.35 -5.19 -0.3 4.12e-7 Schizophrenia; CESC cis rs654950 0.840 rs2810551 chr1:41995402 G/A cg06885757 chr1:42089581 HIVEP3 -0.44 -6.82 -0.39 6.21e-11 Airway imaging phenotypes; CESC cis rs4888262 0.545 rs4072450 chr16:74666634 G/C cg01733217 chr16:74700730 RFWD3 0.92 12.31 0.6 7.71e-28 Testicular germ cell tumor; CESC cis rs72781680 0.851 rs12612830 chr2:24134599 C/T cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12581730 chr6:170599861 DLL1 -0.65 -7.6 -0.42 4.98e-13 Gut microbiome composition (summer); CESC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC trans rs116095464 0.510 rs73016876 chr5:244475 T/C cg00938859 chr5:1591904 SDHAP3 0.68 7.38 0.41 2.02e-12 Breast cancer; CESC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg16545954 chr1:2118288 C1orf86 -0.33 -6.12 -0.35 3.4e-9 Height; CESC cis rs7296418 0.961 rs10848428 chr12:123572495 C/T cg05973401 chr12:123451056 ABCB9 0.6 7.84 0.43 1.11e-13 Platelet count; CESC trans rs7943203 0.962 rs2118308 chr11:108315463 C/G cg01416241 chr5:148737479 PCYOX1L -0.48 -6.07 -0.35 4.35e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg14983838 chr19:29218262 NA 0.5 5.79 0.33 2.02e-8 Methadone dose in opioid dependence; CESC cis rs9399137 0.507 rs6569986 chr6:135311641 T/C cg22676075 chr6:135203613 NA 0.53 7.09 0.4 1.22e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs709400 0.894 rs56017123 chr14:104075277 G/A cg12935359 chr14:103987150 CKB -0.47 -5.94 -0.34 8.91e-9 Body mass index; CESC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg19346786 chr7:2764209 NA -0.45 -6.59 -0.38 2.32e-10 Height; CESC cis rs9905704 0.681 rs4277402 chr17:56581651 C/G cg12560992 chr17:57184187 TRIM37 -0.65 -5.99 -0.35 6.78e-9 Testicular germ cell tumor; CESC cis rs6580649 0.882 rs2286022 chr12:48436647 G/A cg24011408 chr12:48396354 COL2A1 -0.44 -5.35 -0.31 1.86e-7 Lung cancer; CESC cis rs989128 0.600 rs9913430 chr17:48628470 A/T cg24438145 chr17:48624694 SPATA20 0.45 5.42 0.32 1.37e-7 Type 2 diabetes; CESC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs12142240 0.692 rs7532149 chr1:46824932 A/C cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.1 -0.35 3.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9916302 0.784 rs4795361 chr17:37573446 G/A cg07936489 chr17:37558343 FBXL20 -0.81 -11.75 -0.59 6.21e-26 Glomerular filtration rate (creatinine); CESC cis rs4595586 0.525 rs4450203 chr12:39381493 T/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.78 8.21 0.45 9.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg13206674 chr6:150067644 NUP43 0.41 5.68 0.33 3.47e-8 Lung cancer; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg13220357 chr22:25202163 SGSM1 -0.47 -6.14 -0.35 3.05e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1878931 0.615 rs4786412 chr16:3440390 C/T cg00484396 chr16:3507460 NAT15 -0.4 -6.23 -0.36 1.82e-9 Body mass index (adult); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11159084 chr1:236767889 HEATR1 0.61 6.55 0.37 3.04e-10 Gut microbiome composition (summer); CESC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.48 6.05 0.35 4.88e-9 Tonsillectomy; CESC cis rs6502050 0.835 rs56095560 chr17:80151304 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.59e-10 Life satisfaction; CESC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg24633833 chr3:10029261 TMEM111 0.44 5.11 0.3 6.19e-7 Alzheimer's disease; CESC cis rs1348850 0.651 rs4893931 chr2:178228212 T/C cg22681709 chr2:178499509 PDE11A -0.34 -5.26 -0.31 3.02e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4930103 0.619 rs739905 chr11:1980360 G/C cg23202291 chr11:1979235 NA 0.4 5.6 0.33 5.5e-8 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg18252515 chr7:66147081 NA -0.43 -5.62 -0.33 4.86e-8 Aortic root size; CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg15383120 chr6:291909 DUSP22 -0.65 -8.2 -0.45 1.07e-14 Menopause (age at onset); CESC cis rs7944584 0.511 rs10838731 chr11:47607135 C/T cg20307385 chr11:47447363 PSMC3 0.83 12.25 0.6 1.27e-27 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs708547 0.874 rs1713978 chr4:57875879 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 7.91 0.44 6.86e-14 Response to bleomycin (chromatid breaks); CESC cis rs3008870 0.755 rs2815362 chr1:67496803 C/T cg02640540 chr1:67518911 SLC35D1 0.45 5.55 0.32 6.76e-8 Lymphocyte percentage of white cells; CESC cis rs9814567 1.000 rs2887797 chr3:134202506 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.37 -0.36 8.13e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.69 -10.89 -0.56 4.48e-23 Personality dimensions; CESC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg17143192 chr8:8559678 CLDN23 0.71 8.49 0.46 1.46e-15 Obesity-related traits; CESC trans rs7819412 0.668 rs2409715 chr8:11010136 A/T cg15556689 chr8:8085844 FLJ10661 -0.54 -6.71 -0.38 1.16e-10 Triglycerides; CESC cis rs9300255 0.602 rs1790098 chr12:123655481 A/C cg00376283 chr12:123451042 ABCB9 0.7 8.57 0.47 8.55e-16 Neutrophil percentage of white cells; CESC cis rs1878931 0.668 rs11643983 chr16:3438865 G/A cg00484396 chr16:3507460 NAT15 -0.39 -6.2 -0.36 2.18e-9 Body mass index (adult); CESC cis rs728616 0.867 rs61860412 chr10:81728486 G/A cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs644799 0.965 rs11021310 chr11:95502106 A/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 15.06 0.68 1.9e-37 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg14159672 chr1:205819179 PM20D1 0.4 5.15 0.3 4.99e-7 Parkinson's disease; CESC cis rs7520050 0.801 rs6703960 chr1:46232723 C/T cg24296786 chr1:45957014 TESK2 0.46 5.99 0.35 6.97e-9 Red blood cell count;Reticulocyte count; CESC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg14416726 chr6:151773293 C6orf211;RMND1 0.54 7.3 0.41 3.26e-12 Menarche (age at onset); CESC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC cis rs11645898 0.810 rs72787046 chr16:72079342 A/G cg14768367 chr16:72042858 DHODH -0.84 -6.92 -0.39 3.43e-11 Blood protein levels; CESC cis rs5758659 0.679 rs134870 chr22:42652317 T/C cg15557168 chr22:42548783 NA -0.34 -5.2 -0.3 4e-7 Cognitive function; CESC cis rs7259376 0.875 rs10409520 chr19:22512477 C/T cg02657401 chr19:22469223 NA -0.26 -5.35 -0.31 1.86e-7 Menopause (age at onset); CESC cis rs910316 1.000 rs10142865 chr14:75555624 G/A cg08847533 chr14:75593920 NEK9 1.02 20.11 0.78 2.88e-55 Height; CESC cis rs1045714 0.895 rs17833498 chr7:2647007 A/G cg20813462 chr7:2646259 IQCE -0.62 -5.41 -0.32 1.43e-7 Urate levels in lean individuals; CESC trans rs4245128 0.930 rs4936212 chr11:112794836 C/T cg10894232 chr8:11772343 NA 0.37 6.1 0.35 3.78e-9 Life satisfaction; CESC cis rs8014204 0.804 rs34956813 chr14:75254167 G/A cg08847533 chr14:75593920 NEK9 0.47 5.97 0.34 7.75e-9 Caffeine consumption; CESC cis rs9858542 0.953 rs7622302 chr3:49547561 T/C cg07274523 chr3:49395745 GPX1 0.65 7.92 0.44 6.77e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7855088 1.000 rs879275 chr9:100781720 G/C cg13688889 chr9:100608707 NA -0.38 -5.7 -0.33 3.13e-8 Serum thyroid-stimulating hormone levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15929228 chr2:240323491 HDAC4 0.57 6.69 0.38 1.33e-10 Gut microbiome composition (summer); CESC cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.92 8.05 0.44 2.75e-14 Initial pursuit acceleration; CESC cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg23283495 chr1:209979779 IRF6 0.48 5.59 0.32 5.57e-8 Cleft lip with or without cleft palate; CESC cis rs1215050 0.716 rs356549 chr4:98699344 A/G cg05340658 chr4:99064831 C4orf37 0.5 6.36 0.36 8.61e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 10.23 0.53 6.23e-21 Platelet count; CESC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg02038168 chr22:39784481 NA 0.57 6.94 0.39 3e-11 Intelligence (multi-trait analysis); CESC cis rs4481887 0.927 rs4390208 chr1:248472211 C/T cg00666640 chr1:248458726 OR2T12 0.33 5.64 0.33 4.25e-8 Common traits (Other); CESC cis rs2072732 0.861 rs34408665 chr1:2950067 A/G cg15211996 chr1:2936768 ACTRT2 0.36 6.33 0.36 1.02e-9 Plateletcrit; CESC cis rs1670533 1.000 rs10084889 chr4:1053815 G/A cg27284194 chr4:1044797 NA 0.46 5.86 0.34 1.35e-8 Recombination rate (females); CESC cis rs10197940 0.624 rs10497082 chr2:152355258 T/C cg19508488 chr2:152266495 RIF1 0.51 5.45 0.32 1.17e-7 Lung cancer; CESC cis rs11098499 0.564 rs11098507 chr4:120288286 G/A cg09307838 chr4:120376055 NA 0.87 12.13 0.6 3.13e-27 Corneal astigmatism; CESC trans rs747782 0.528 rs624348 chr11:48400795 G/A cg15704280 chr7:45808275 SEPT13 -0.68 -6.25 -0.36 1.61e-9 Intraocular pressure; CESC cis rs9911578 1.000 rs9892062 chr17:56976981 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.05 0.3 8.26e-7 Intelligence (multi-trait analysis); CESC cis rs727563 0.594 rs5758408 chr22:42077737 A/C cg06634786 chr22:41940651 POLR3H 0.62 6.25 0.36 1.67e-9 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06788172 chr15:51915087 DMXL2 0.59 6.72 0.38 1.14e-10 Gut microbiome composition (summer); CESC cis rs9911578 1.000 rs3744108 chr17:56585872 G/C cg12560992 chr17:57184187 TRIM37 -0.91 -15.19 -0.68 6.51e-38 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg20151795 chr6:28129481 ZNF389 0.46 5.83 0.34 1.65e-8 Depression; CESC cis rs67311347 0.594 rs12629111 chr3:40285351 T/C cg09455208 chr3:40491958 NA 0.32 5.32 0.31 2.17e-7 Renal cell carcinoma; CESC cis rs910316 0.810 rs77939209 chr14:75670070 A/G cg11812906 chr14:75593930 NEK9 -0.84 -13.59 -0.64 2.87e-32 Height; CESC trans rs877282 0.898 rs11253356 chr10:768604 G/A cg22713356 chr15:30763199 NA 0.9 9.35 0.5 3.78e-18 Uric acid levels; CESC cis rs1707322 0.752 rs28550303 chr1:46188914 G/T cg03146154 chr1:46216737 IPP 0.83 11.68 0.58 1.09e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg22143856 chr6:28129313 ZNF389 0.53 6.73 0.38 1.06e-10 Depression; CESC cis rs5758659 0.652 rs5758537 chr22:42397042 G/T cg15557168 chr22:42548783 NA -0.43 -6.35 -0.36 9.55e-10 Cognitive function; CESC cis rs597539 0.654 rs7107137 chr11:68623712 A/G cg21963583 chr11:68658836 MRPL21 0.4 5.42 0.32 1.37e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg06221963 chr1:154839813 KCNN3 -0.69 -12.3 -0.6 8.47e-28 Prostate cancer; CESC cis rs9584850 0.834 rs7339274 chr13:99120272 A/G cg20750642 chr13:99100586 FARP1 0.38 5.93 0.34 9.48e-9 Neuroticism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22754179 chr19:42901115 NA 0.45 6.22 0.36 1.89e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg02428538 chr16:24856791 SLC5A11 0.48 5.07 0.3 7.62e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9811920 0.609 rs6440938 chr3:99652092 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.64 -10.11 -0.53 1.53e-20 Axial length; CESC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg12718519 chr1:2058417 PRKCZ -0.25 -5.25 -0.31 3.18e-7 Height; CESC cis rs9614461 0.702 rs3788648 chr22:45727180 G/A cg13318129 chr22:45737514 FAM118A 0.49 5.12 0.3 5.79e-7 Tonsillectomy; CESC cis rs1707322 1.000 rs785465 chr1:46522577 G/T cg05343316 chr1:45956843 TESK2 0.45 5.58 0.32 5.89e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2637266 1.000 rs7900616 chr10:78367075 C/T cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg12923728 chr3:195709715 SDHAP1 -0.66 -8.75 -0.47 2.61e-16 Pancreatic cancer; CESC cis rs12950390 0.814 rs11659069 chr17:45834275 G/T cg00777063 chr17:45855553 NA -0.41 -6.11 -0.35 3.53e-9 IgG glycosylation; CESC cis rs9906944 0.707 rs4794020 chr17:47111399 C/T cg09029085 chr17:47094198 IGF2BP1 0.25 5.06 0.3 7.94e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs2070433 0.752 rs11700468 chr21:47776391 C/T cg12379764 chr21:47803548 PCNT 0.67 7.43 0.42 1.52e-12 Lymphocyte counts; CESC cis rs7408868 0.764 rs12610803 chr19:15260682 A/C cg14696996 chr19:15285081 NOTCH3 1.11 11.21 0.57 3.98e-24 Pulse pressure; CESC cis rs9902453 0.967 rs61014003 chr17:28485233 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 8.09 0.44 2.2e-14 Coffee consumption (cups per day); CESC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg11168104 chr5:1857477 NA -0.38 -5.67 -0.33 3.63e-8 Cardiovascular disease risk factors; CESC cis rs748404 0.650 rs556851 chr15:43571219 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.51 8.03 0.44 3.27e-14 Lung cancer; CESC cis rs7845219 0.525 rs7820818 chr8:95919231 G/A cg23172400 chr8:95962367 TP53INP1 -0.4 -7.29 -0.41 3.51e-12 Type 2 diabetes; CESC cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg17366294 chr4:99064904 C4orf37 0.56 7.55 0.42 6.85e-13 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18598152 chr14:24020957 NA 0.44 6.23 0.36 1.85e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs763121 0.853 rs6001182 chr22:39047443 A/G cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.06 12.34 0.6 5.85e-28 Gut microbiome composition (summer); CESC cis rs2820292 0.595 rs10800793 chr1:201825750 A/G cg11586189 chr1:201857591 SHISA4 -0.36 -5.85 -0.34 1.43e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg04025307 chr7:1156635 C7orf50 0.39 5.27 0.31 2.77e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7851660 0.967 rs6478437 chr9:100607497 A/G cg13688889 chr9:100608707 NA -0.68 -10.61 -0.55 3.8e-22 Strep throat; CESC cis rs60843830 0.661 rs7588043 chr2:104979 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.51 6.08 0.35 4.11e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs9325144 0.723 rs11169535 chr12:39183494 C/T cg23762105 chr12:34175262 ALG10 0.45 6.14 0.35 3.01e-9 Morning vs. evening chronotype; CESC cis rs9362426 0.503 rs34977536 chr6:88112368 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -5.36 -0.31 1.79e-7 Depressive episodes in bipolar disorder; CESC cis rs116095464 0.558 rs10065584 chr5:253997 G/A cg22857025 chr5:266934 NA -1.31 -13.97 -0.65 1.35e-33 Breast cancer; CESC cis rs116095464 0.558 rs9312977 chr5:221916 G/C cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.74 0.33 2.63e-8 Breast cancer; CESC cis rs933688 1.000 rs10059163 chr5:90742444 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 14.08 0.65 5.45e-34 Smoking behavior; CESC cis rs3213545 0.659 rs2259693 chr12:121457995 G/A cg02403541 chr12:121454288 C12orf43 0.74 10.68 0.55 2.25e-22 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs3785574 0.962 rs114027117 chr17:61939935 T/A cg06873352 chr17:61820015 STRADA 0.46 6.8 0.39 6.85e-11 Height; CESC cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg01181863 chr3:195395398 SDHAP2 -0.5 -5.85 -0.34 1.47e-8 Pancreatic cancer; CESC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg27532560 chr4:187881888 NA -0.4 -6.2 -0.36 2.12e-9 Lobe attachment (rater-scored or self-reported); CESC trans rs2530545 0.851 rs10246319 chr7:34692257 G/A cg14080982 chr15:71736038 THSD4 -0.48 -6.27 -0.36 1.43e-9 IgG glycosylation; CESC trans rs9951602 0.512 rs12607612 chr18:76651799 G/A cg02800362 chr5:177631904 HNRNPAB 0.66 8.64 0.47 5.41e-16 Obesity-related traits; CESC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg11890956 chr21:40555474 PSMG1 1.18 23.84 0.83 6.88e-68 Cognitive function; CESC cis rs2635047 0.967 rs2576056 chr18:44675462 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.49 6.59 0.38 2.33e-10 Educational attainment; CESC cis rs6752107 1.000 rs6752107 chr2:234161448 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.91 0.39 3.61e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs7772486 0.806 rs2265477 chr6:146212338 T/C cg23711669 chr6:146136114 FBXO30 0.77 10.91 0.56 3.81e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg11941060 chr3:133502564 NA -0.48 -6.65 -0.38 1.67e-10 Iron status biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18487609 chr19:18392554 JUND 0.68 7.83 0.43 1.21e-13 Gut microbiome composition (summer); CESC cis rs7914558 0.966 rs10786727 chr10:104698523 G/A cg08650961 chr10:104748594 CNNM2 0.32 5.16 0.3 4.94e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs11764590 0.694 rs55860148 chr7:2105594 G/A cg12017631 chr7:1980892 MAD1L1 -0.42 -5.17 -0.3 4.71e-7 Neuroticism; CESC cis rs6088580 0.524 rs6088565 chr20:33254986 A/C cg07148914 chr20:33460835 GGT7 -0.44 -5.42 -0.32 1.34e-7 Glomerular filtration rate (creatinine); CESC cis rs712039 0.652 rs712038 chr17:35762557 G/A cg16670864 chr17:35848621 DUSP14 0.48 6.12 0.35 3.37e-9 Tuberculosis; CESC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg08888203 chr3:10149979 C3orf24 0.5 6.02 0.35 5.84e-9 Alzheimer's disease; CESC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg04287289 chr16:89883240 FANCA 0.72 10.49 0.54 9.56e-22 Vitiligo; CESC cis rs1153858 0.887 rs28569043 chr15:45730926 A/T cg21132104 chr15:45694354 SPATA5L1 0.73 8.89 0.48 9.73e-17 Homoarginine levels; CESC cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.53 0.51 1.08e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs6582630 0.555 rs56228141 chr12:38518652 T/G cg13010199 chr12:38710504 ALG10B 0.49 6.43 0.37 6.06e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs9640161 0.830 rs3757424 chr7:150067679 C/A cg21361702 chr7:150065534 REPIN1 0.57 7.54 0.42 7.72e-13 Blood protein levels;Circulating chemerin levels; CESC cis rs7953508 0.619 rs11107114 chr12:93972927 G/A cg18151635 chr12:93972918 NA -0.48 -6.68 -0.38 1.4e-10 Pubertal anthropometrics; CESC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg05896524 chr21:47604654 C21orf56 0.43 5.6 0.33 5.28e-8 Testicular germ cell tumor; CESC cis rs11650494 0.908 rs8076023 chr17:47399633 C/G cg08112188 chr17:47440006 ZNF652 0.98 7.01 0.4 1.95e-11 Prostate cancer; CESC cis rs2404602 0.735 rs437131 chr15:76781051 C/T cg23625390 chr15:77176239 SCAPER 0.38 5.52 0.32 8.13e-8 Blood metabolite levels; CESC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.51 0.37 3.65e-10 Prudent dietary pattern; CESC cis rs559928 0.606 rs76653616 chr11:63936139 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.84 0.34 1.55e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs7208859 0.673 rs11653955 chr17:29033292 C/A cg14008862 chr17:28927542 LRRC37B2 0.67 5.18 0.3 4.41e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs34779708 0.966 rs1213392 chr10:35430285 C/T cg03585969 chr10:35415529 CREM 0.67 8.81 0.48 1.66e-16 Inflammatory bowel disease;Crohn's disease; CESC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.51e-7 Life satisfaction; CESC cis rs7394190 0.748 rs4082339 chr10:75539812 C/T cg07699608 chr10:75541558 CHCHD1 -0.59 -5.21 -0.3 3.74e-7 Incident atrial fibrillation; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11438737 chr11:43918796 LOC729799;ALKBH3 -0.5 -6.59 -0.38 2.31e-10 Systemic lupus erythematosus; CESC cis rs6460942 0.915 rs7802454 chr7:12454508 A/G cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs7208859 0.673 rs8077116 chr17:29140162 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg09323728 chr8:95962352 TP53INP1 -0.38 -8.08 -0.44 2.35e-14 Type 2 diabetes; CESC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg23758822 chr17:41437982 NA 1.03 16.08 0.7 4.57e-41 Menopause (age at onset); CESC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg19592336 chr6:28129416 ZNF389 0.62 8.32 0.46 4.64e-15 Depression; CESC cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4889855 0.614 rs7221663 chr17:78484166 T/C cg16591659 chr17:78472290 NA -0.51 -7.57 -0.42 6.27e-13 Fractional excretion of uric acid; CESC cis rs4566357 0.576 rs10187255 chr2:227913442 T/A cg05526886 chr2:227700861 RHBDD1 -0.47 -6.27 -0.36 1.45e-9 Coronary artery disease; CESC cis rs7843479 0.582 rs7009693 chr8:21775314 C/T cg17168535 chr8:21777572 XPO7 0.74 11.9 0.59 1.86e-26 Mean corpuscular volume; CESC trans rs13098911 0.540 rs13069079 chr3:46000870 G/A cg10236987 chr1:228114221 WNT9A 0.57 6.07 0.35 4.38e-9 Celiac disease; CESC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg00409905 chr10:38381863 ZNF37A -0.51 -6.79 -0.38 7.54e-11 Extrinsic epigenetic age acceleration; CESC cis rs4481887 0.830 rs9662041 chr1:248484701 A/T cg00666640 chr1:248458726 OR2T12 0.36 6.17 0.35 2.56e-9 Common traits (Other); CESC cis rs9929218 0.859 rs9936682 chr16:68748223 A/G cg02972257 chr16:68554789 NA 0.57 6.39 0.37 7.31e-10 Colorectal cancer; CESC cis rs938554 0.784 rs13102218 chr4:9976113 G/T cg00071950 chr4:10020882 SLC2A9 0.48 5.68 0.33 3.49e-8 Blood metabolite levels; CESC cis rs1322639 0.618 rs9505942 chr6:169591793 T/C cg04662567 chr6:169592167 NA -0.48 -5.17 -0.3 4.61e-7 Pulse pressure; CESC trans rs61931739 0.500 rs6488209 chr12:34319309 A/G cg26384229 chr12:38710491 ALG10B 0.47 6.29 0.36 1.29e-9 Morning vs. evening chronotype; CESC trans rs9951602 0.541 rs56882694 chr18:76647010 C/T cg02800362 chr5:177631904 HNRNPAB 0.62 8.14 0.45 1.57e-14 Obesity-related traits; CESC cis rs6752107 0.935 rs10199278 chr2:234160669 C/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.91 0.39 3.59e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg18876405 chr7:65276391 NA -0.53 -7.38 -0.41 2.09e-12 Aortic root size; CESC cis rs1348850 0.526 rs7607073 chr2:178375065 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.69 6.19 0.36 2.22e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg07648498 chr16:89883185 FANCA 0.5 6.28 0.36 1.41e-9 Vitiligo; CESC cis rs7937682 0.883 rs1611989 chr11:111456299 A/G cg09085632 chr11:111637200 PPP2R1B -0.93 -13.47 -0.64 7.49e-32 Primary sclerosing cholangitis; CESC cis rs712039 0.652 rs853200 chr17:35804114 G/A cg16670864 chr17:35848621 DUSP14 0.44 5.38 0.31 1.63e-7 Tuberculosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04244056 chr16:28835698 ATXN2L 0.59 6.5 0.37 3.99e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.592 rs5751129 chr22:42015765 C/T cg17376030 chr22:41985996 PMM1 -0.53 -5.98 -0.34 7.19e-9 Vitiligo; CESC cis rs6121246 0.738 rs6121242 chr20:30410877 T/C cg13852791 chr20:30311386 BCL2L1 0.81 8.16 0.45 1.33e-14 Mean corpuscular hemoglobin; CESC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg00166722 chr3:10149974 C3orf24 0.53 6.65 0.38 1.64e-10 Alzheimer's disease; CESC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg08109568 chr15:31115862 NA -0.71 -9.55 -0.51 9.27e-19 Huntington's disease progression; CESC cis rs2880765 0.835 rs12324277 chr15:86041735 G/A cg19183879 chr15:85880815 NA -0.25 -5.09 -0.3 6.82e-7 Coronary artery disease; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg07092213 chr7:1199455 ZFAND2A -0.46 -6.35 -0.36 9.42e-10 Longevity;Endometriosis; CESC cis rs798554 1.000 rs798560 chr7:2758309 A/G cg19717773 chr7:2847554 GNA12 -0.52 -7.46 -0.42 1.23e-12 Height; CESC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg27588902 chr6:42928151 GNMT 0.26 5.25 0.31 3.08e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9486719 0.947 rs12194971 chr6:96911073 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.45e-15 Migraine;Coronary artery disease; CESC cis rs1506636 1.000 rs60689684 chr7:123370403 C/T cg03229431 chr7:123269106 ASB15 0.52 6.69 0.38 1.33e-10 Plateletcrit;Platelet count; CESC cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg17366294 chr4:99064904 C4orf37 0.58 8.3 0.45 5.45e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg23758822 chr17:41437982 NA 1.02 14.33 0.66 7.2e-35 Menopause (age at onset); CESC cis rs7917772 0.582 rs12411442 chr10:104349531 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.64 0.33 4.41e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2072732 0.821 rs12038530 chr1:2946726 T/A cg03976712 chr1:2946727 NA 0.32 5.35 0.31 1.9e-7 Plateletcrit; CESC trans rs11148252 0.595 rs9526968 chr13:53240183 T/C cg18335740 chr13:41363409 SLC25A15 0.51 6.99 0.39 2.17e-11 Lewy body disease; CESC cis rs870825 0.616 rs28445002 chr4:185648977 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC trans rs10242455 0.557 rs77997620 chr7:99070415 G/T cg09045935 chr12:6379348 NA 0.89 7.37 0.41 2.14e-12 Blood metabolite levels; CESC cis rs2228479 0.850 rs17233664 chr16:89810628 C/T cg06558623 chr16:89946397 TCF25 1.17 9.44 0.5 1.96e-18 Skin colour saturation; CESC cis rs7845219 0.544 rs7001535 chr8:95921090 C/G cg23172400 chr8:95962367 TP53INP1 -0.37 -6.78 -0.38 7.89e-11 Type 2 diabetes; CESC cis rs1801251 1.000 rs13008942 chr2:233594875 G/A cg08000102 chr2:233561755 GIGYF2 0.68 9.52 0.5 1.13e-18 Coronary artery disease; CESC cis rs4808199 0.948 rs7259434 chr19:19428805 A/T cg03709012 chr19:19516395 GATAD2A 1.03 11.72 0.58 7.52e-26 Nonalcoholic fatty liver disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25942178 chr2:85829833 TMEM150A -0.48 -6.07 -0.35 4.34e-9 Ulcerative colitis; CESC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg22143856 chr6:28129313 ZNF389 -0.44 -5.91 -0.34 1.05e-8 Depression; CESC cis rs12701220 0.689 rs12536282 chr7:1115650 C/T cg26769984 chr7:1090371 C7orf50 0.55 5.73 0.33 2.66e-8 Bronchopulmonary dysplasia; CESC cis rs11696501 0.688 rs6124727 chr20:44325623 T/C cg11783356 chr20:44313418 WFDC10B -0.31 -5.09 -0.3 6.94e-7 Brain structure; CESC cis rs142518269 1 rs142518269 chr2:24087095 G/A cg08917208 chr2:24149416 ATAD2B 1.11 10.18 0.53 9.57e-21 Mean corpuscular hemoglobin; CESC cis rs55823223 0.564 rs936391 chr17:73847799 A/G cg08125733 chr17:73851984 WBP2 -0.79 -10.7 -0.55 1.88e-22 Psoriasis; CESC cis rs62229266 0.835 rs998384 chr21:37445526 G/C cg12218747 chr21:37451666 NA -0.46 -6.35 -0.36 9.06e-10 Mitral valve prolapse; CESC cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg03433033 chr1:76189801 ACADM 0.69 8.23 0.45 8.78e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs832540 0.966 rs252923 chr5:56205662 T/G cg14703610 chr5:56206110 C5orf35 0.5 6.49 0.37 4.31e-10 Coronary artery disease; CESC cis rs9894429 0.682 rs7406360 chr17:79591545 G/A cg21984481 chr17:79567631 NPLOC4 -0.56 -8.99 -0.48 4.98e-17 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21932983 chr1:6321378 GPR153 0.54 6.61 0.38 2.1e-10 Gut microbiome composition (summer); CESC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg01341218 chr17:43662625 NA -0.53 -7.32 -0.41 3.05e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1534166 0.602 rs3817524 chr3:133526403 C/T cg27366882 chr3:133540807 NA -0.28 -5.1 -0.3 6.43e-7 Alcohol consumption (transferrin glycosylation); CESC cis rs9682041 0.696 rs10936626 chr3:170095019 G/A cg11886554 chr3:170076028 SKIL 0.7 6.5 0.37 3.93e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg22442454 chr1:209979470 IRF6 0.43 5.13 0.3 5.62e-7 Cleft lip with or without cleft palate; CESC cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg11366901 chr6:160182831 ACAT2 0.76 9.16 0.49 1.45e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs698833 0.926 rs1085485 chr2:44616728 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.74 0.33 2.54e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.37 -0.41 2.18e-12 Alzheimer's disease; CESC cis rs6430585 0.528 rs12476127 chr2:136763242 A/G cg07169764 chr2:136633963 MCM6 1.3 19.87 0.77 2.02e-54 Corneal structure; CESC cis rs6062302 0.545 rs2297430 chr20:62229244 T/C cg09650180 chr20:62225654 GMEB2 -0.81 -9.23 -0.49 8.68e-18 Glioblastoma; CESC cis rs1020064 0.636 rs1529974 chr2:105927996 T/C cg02079111 chr2:105885981 TGFBRAP1 0.37 5.13 0.3 5.61e-7 AIDS; CESC cis rs561341 0.609 rs9906443 chr17:30185565 C/T cg13647721 chr17:30228624 UTP6 -0.72 -8.19 -0.45 1.13e-14 Hip circumference adjusted for BMI; CESC cis rs6964587 0.967 rs10953065 chr7:91808915 A/G cg17063962 chr7:91808500 NA -0.58 -8.04 -0.44 2.92e-14 Breast cancer; CESC cis rs7267979 0.966 rs6050567 chr20:25354561 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.13 -0.74 2.42e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs9389248 0.737 rs56358308 chr6:135306980 A/T cg24558204 chr6:135376177 HBS1L 0.7 9.61 0.51 5.93e-19 High light scatter reticulocyte percentage of red cells; CESC cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg20891283 chr12:69753455 YEATS4 0.91 15.03 0.68 2.41e-37 Blood protein levels; CESC cis rs36051895 0.632 rs11793886 chr9:5125469 A/G cg02405213 chr9:5042618 JAK2 -0.5 -5.91 -0.34 1.05e-8 Pediatric autoimmune diseases; CESC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg20573242 chr4:122745356 CCNA2 0.62 7.47 0.42 1.14e-12 Type 2 diabetes; CESC cis rs6087990 0.769 rs17123658 chr20:31390840 C/A cg13636640 chr20:31349939 DNMT3B 0.76 11.67 0.58 1.11e-25 Ulcerative colitis; CESC cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg23711669 chr6:146136114 FBXO30 0.97 14.77 0.67 2.05e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg07747251 chr5:1868357 NA 0.32 5.26 0.31 2.94e-7 Cardiovascular disease risk factors; CESC cis rs9815354 1.000 rs56121764 chr3:41883975 T/C cg03022575 chr3:42003672 ULK4 0.58 6.01 0.35 5.96e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04593571 chr2:85361052 TCF7L1 0.52 6.12 0.35 3.38e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.591 rs6519993 chr22:46656479 A/G cg09491104 chr22:46646882 C22orf40 -0.6 -9.2 -0.49 1.09e-17 LDL cholesterol;Cholesterol, total; CESC cis rs2072732 0.656 rs113272167 chr1:2954051 C/T cg15211996 chr1:2936768 ACTRT2 0.34 5.78 0.33 2.08e-8 Plateletcrit; CESC cis rs7208859 0.623 rs3794796 chr17:29130880 G/C cg14008862 chr17:28927542 LRRC37B2 0.69 5.36 0.31 1.79e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6693567 0.565 rs471657 chr1:150276461 G/A cg09579323 chr1:150459698 TARS2 -0.45 -5.85 -0.34 1.46e-8 Migraine; CESC cis rs4595586 0.545 rs3911798 chr12:39389901 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.57 0.42 6.13e-13 Morning vs. evening chronotype; CESC cis rs3540 0.597 rs3539 chr15:91045419 G/T cg22089800 chr15:90895588 ZNF774 -0.65 -8.98 -0.48 5.06e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs3747547 0.685 rs72726094 chr9:38126746 G/T cg13774184 chr9:37916125 SHB -0.63 -5.21 -0.3 3.86e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs637571 0.607 rs589253 chr11:65693080 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 5.75 0.33 2.42e-8 Eosinophil percentage of white cells; CESC cis rs6121246 0.559 rs6087782 chr20:30391580 C/T cg13852791 chr20:30311386 BCL2L1 0.83 10.8 0.55 8.95e-23 Mean corpuscular hemoglobin; CESC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg16606324 chr3:10149918 C3orf24 0.43 5.97 0.34 7.65e-9 Alzheimer's disease; CESC cis rs10078 0.515 rs6872510 chr5:481610 T/C cg08916839 chr5:415575 AHRR 0.6 6.92 0.39 3.35e-11 Fat distribution (HIV); CESC cis rs8017423 0.967 rs55894943 chr14:90714799 A/G cg14092571 chr14:90743983 NA -0.58 -8.71 -0.47 3.33e-16 Mortality in heart failure; CESC cis rs11792861 0.888 rs11794648 chr9:111829792 C/T cg05043794 chr9:111880884 C9orf5 -0.38 -6.43 -0.37 5.83e-10 Menarche (age at onset); CESC cis rs1348850 0.567 rs3770005 chr2:178528874 A/G cg23306229 chr2:178417860 TTC30B 0.53 6.93 0.39 3.18e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs807669 0.548 rs723414 chr22:19185736 G/A cg02655711 chr22:19163373 SLC25A1 0.7 10.53 0.54 6.71e-22 Metabolite levels; CESC cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg12386194 chr3:101231763 SENP7 0.61 6.47 0.37 4.81e-10 Colonoscopy-negative controls vs population controls; CESC cis rs57506017 0.585 rs1468804 chr7:12275508 A/G cg23422036 chr7:12250390 TMEM106B 0.39 5.41 0.32 1.41e-7 Neuroticism; CESC cis rs17209837 0.920 rs4148817 chr7:87087397 C/G cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC cis rs4843747 0.671 rs72818576 chr16:88111019 C/G cg03395651 chr16:88107091 BANP 0.47 5.43 0.32 1.26e-7 Menopause (age at onset); CESC cis rs2228479 0.850 rs117285117 chr16:89910250 T/G cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs2180341 0.680 rs9388554 chr6:127576234 C/G cg27446573 chr6:127587934 RNF146 0.83 11.71 0.58 8.67e-26 Breast cancer; CESC cis rs6736093 0.763 rs4848973 chr2:112790562 G/A cg12686935 chr2:112915763 FBLN7 -0.41 -5.45 -0.32 1.13e-7 Coronary artery disease; CESC cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.58 7.02 0.4 1.87e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8077577 0.708 rs3829590 chr17:18134265 C/A cg16794390 chr17:18148240 FLII -0.44 -6.58 -0.37 2.46e-10 Obesity-related traits; CESC cis rs1808579 0.935 rs4800162 chr18:21117419 G/T cg14672496 chr18:21087552 C18orf8 0.39 6.05 0.35 5.03e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs6460942 1.000 rs79659770 chr7:12326371 T/C cg20607287 chr7:12443886 VWDE -0.8 -8.57 -0.47 8.66e-16 Coronary artery disease; CESC cis rs6087990 0.806 rs4911257 chr20:31359574 T/C cg13636640 chr20:31349939 DNMT3B 0.79 12.0 0.59 8.62e-27 Ulcerative colitis; CESC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg04414720 chr1:150670196 GOLPH3L 0.55 7.44 0.42 1.44e-12 Melanoma; CESC cis rs7078219 1.000 rs6584278 chr10:101278099 C/T cg09788492 chr10:101292477 NKX2-3 0.28 5.16 0.3 4.74e-7 Dental caries; CESC cis rs7089973 0.549 rs7094440 chr10:116745408 T/C cg23260525 chr10:116636907 FAM160B1 0.3 5.24 0.31 3.21e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs10911363 0.592 rs2702182 chr1:183516440 C/T cg09173681 chr1:183549694 NCF2 0.51 7.56 0.42 6.81e-13 Systemic lupus erythematosus; CESC cis rs523522 0.962 rs2168319 chr12:120933217 C/T cg12219531 chr12:120966889 COQ5 0.75 9.79 0.52 1.59e-19 High light scatter reticulocyte count; CESC cis rs13064411 0.696 rs6808394 chr3:113122524 T/G cg18753928 chr3:113234510 CCDC52 -0.5 -5.51 -0.32 8.64e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs7959452 0.718 rs10878963 chr12:69717166 T/G cg20891283 chr12:69753455 YEATS4 0.55 7.32 0.41 2.96e-12 Blood protein levels; CESC cis rs7560272 0.723 rs7566315 chr2:73791808 C/T cg20560298 chr2:73613845 ALMS1 -0.5 -7.19 -0.4 6.73e-12 Schizophrenia; CESC cis rs208520 0.955 rs208538 chr6:66964492 C/G cg07460842 chr6:66804631 NA -0.8 -9.14 -0.49 1.64e-17 Exhaled nitric oxide output; CESC cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg09640425 chr7:158790006 NA -0.38 -5.92 -0.34 9.68e-9 Facial morphology (factor 20); CESC cis rs3820928 0.904 rs2894623 chr2:227766112 T/C cg05526886 chr2:227700861 RHBDD1 -0.44 -5.65 -0.33 4.24e-8 Pulmonary function; CESC cis rs3540 0.512 rs11633872 chr15:91080512 G/A cg22089800 chr15:90895588 ZNF774 -0.6 -7.73 -0.43 2.22e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg19592336 chr6:28129416 ZNF389 0.53 7.02 0.4 1.85e-11 Parkinson's disease; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg13877285 chr8:26148873 PPP2R2A 0.5 6.26 0.36 1.52e-9 Myopia (pathological); CESC trans rs7070678 0.905 rs10826650 chr10:29814284 T/C cg06477056 chr5:175110609 HRH2 0.35 6.61 0.38 2.15e-10 Platelet thrombus formation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05463257 chr3:182782445 MCCC1 0.45 6.27 0.36 1.45e-9 Fibrinogen levels; CESC cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg22307029 chr19:49891270 CCDC155 0.55 6.0 0.35 6.6e-9 Multiple sclerosis; CESC cis rs7254114 0.578 rs6511727 chr19:11315817 G/T cg02815516 chr19:11306319 KANK2 -0.4 -6.42 -0.37 6.31e-10 Immature fraction of reticulocytes; CESC cis rs10504229 0.679 rs16921677 chr8:58052431 T/C cg24829409 chr8:58192753 C8orf71 -0.5 -6.25 -0.36 1.62e-9 Developmental language disorder (linguistic errors); CESC cis rs7560272 0.538 rs7599453 chr2:73937901 T/G cg20560298 chr2:73613845 ALMS1 0.42 5.84 0.34 1.56e-8 Schizophrenia; CESC cis rs924607 0.898 rs1697990 chr5:626278 A/G cg09021430 chr5:549028 NA 0.36 7.06 0.4 1.49e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1557765 0.527 rs10832782 chr11:17397273 G/C cg15432903 chr11:17409602 KCNJ11 0.42 6.07 0.35 4.32e-9 Body mass index;Social communication problems; CESC cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg04546413 chr19:29218101 NA 0.48 6.08 0.35 4.28e-9 Methadone dose in opioid dependence; CESC cis rs7666738 0.570 rs11097612 chr4:99079772 T/C cg24818145 chr4:99064322 C4orf37 0.39 5.13 0.3 5.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12142240 0.698 rs72677587 chr1:46813982 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs4631830 0.900 rs10763588 chr10:51539762 G/T cg16070123 chr10:51489643 NA -0.34 -5.03 -0.3 9.19e-7 Prostate-specific antigen levels; CESC cis rs13064411 0.696 rs9836396 chr3:113184282 T/C cg18753928 chr3:113234510 CCDC52 -0.46 -5.49 -0.32 9.43e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs796364 0.625 rs1369843 chr2:201088171 A/G cg23649088 chr2:200775458 C2orf69 0.51 5.78 0.33 2.1e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05732876 chr22:22337374 TOP3B -0.51 -6.03 -0.35 5.62e-9 Gut microbiome composition (summer); CESC cis rs7592578 0.713 rs60915953 chr2:191331304 G/C cg10560079 chr2:191398806 TMEM194B -0.65 -5.65 -0.33 4.11e-8 Diastolic blood pressure; CESC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg19346786 chr7:2764209 NA -0.36 -5.17 -0.3 4.71e-7 Height; CESC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg21770322 chr7:97807741 LMTK2 0.58 8.64 0.47 5.26e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs1355223 0.506 rs12294339 chr11:34860199 C/T cg11058730 chr11:34937778 PDHX;APIP -0.44 -5.39 -0.31 1.53e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9354308 0.867 rs2802051 chr6:66536403 C/T cg07460842 chr6:66804631 NA 0.58 6.6 0.38 2.28e-10 Metabolite levels; CESC cis rs7829975 0.871 rs7829826 chr8:8578120 T/A cg15556689 chr8:8085844 FLJ10661 -0.45 -5.59 -0.33 5.5e-8 Mood instability; CESC cis rs959260 0.748 rs4789178 chr17:73368242 C/G cg20590849 chr17:73267439 MIF4GD -0.54 -6.32 -0.36 1.13e-9 Systemic lupus erythematosus; CESC cis rs2235642 0.701 rs2281230 chr16:1601767 T/C cg09080909 chr16:1797204 MAPK8IP3 -0.42 -5.82 -0.34 1.69e-8 Coronary artery disease; CESC cis rs6088590 0.931 rs12625149 chr20:33425812 A/C cg06115741 chr20:33292138 TP53INP2 -0.57 -7.1 -0.4 1.12e-11 Coronary artery disease; CESC cis rs9611565 0.559 rs132765 chr22:42008068 A/G cg06634786 chr22:41940651 POLR3H 0.61 6.03 0.35 5.57e-9 Vitiligo; CESC cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg06212747 chr3:49208901 KLHDC8B 0.7 9.15 0.49 1.59e-17 Parkinson's disease; CESC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg18876405 chr7:65276391 NA 0.5 6.5 0.37 3.98e-10 Aortic root size; CESC cis rs2573652 1.000 rs2581346 chr15:100514178 T/G cg09918751 chr15:100517450 ADAMTS17 -0.39 -7.61 -0.42 4.66e-13 Height; CESC cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg11752832 chr7:134001865 SLC35B4 0.55 7.19 0.4 6.74e-12 Mean platelet volume; CESC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg10553204 chr2:20871195 GDF7 -0.37 -5.18 -0.3 4.43e-7 Abdominal aortic aneurysm; CESC cis rs12122100 0.526 rs12122534 chr1:146504399 A/G cg03526459 chr1:146549940 NA 0.36 5.71 0.33 3e-8 HIV-1 control; CESC cis rs17376456 0.825 rs10038831 chr5:93124115 C/T cg25358565 chr5:93447407 FAM172A 1.1 10.84 0.55 6.88e-23 Diabetic retinopathy; CESC cis rs6456156 0.742 rs6456157 chr6:167527818 C/A cg07741184 chr6:167504864 NA -0.31 -5.18 -0.3 4.44e-7 Primary biliary cholangitis; CESC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs9287719 0.839 rs11683335 chr2:10756665 C/G cg00105475 chr2:10696890 NA 0.37 5.33 0.31 2.11e-7 Prostate cancer; CESC cis rs477692 1.000 rs516704 chr10:131419879 G/A cg05714579 chr10:131428358 MGMT 0.46 6.16 0.35 2.67e-9 Response to temozolomide; CESC cis rs644799 1.000 rs494829 chr11:95571750 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.63 0.47 5.73e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7590368 0.673 rs56140102 chr2:10943256 T/C cg15705551 chr2:10952987 PDIA6 0.54 5.2 0.3 4.09e-7 Educational attainment (years of education); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09941266 chr16:3285496 ZNF200 0.5 6.54 0.37 3.11e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1941023 0.503 rs4939348 chr11:60135871 A/C cg08716584 chr11:60157161 MS4A7 -0.54 -8.74 -0.47 2.67e-16 Congenital heart disease (maternal effect); CESC cis rs559928 0.606 rs11231710 chr11:63925743 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.92 0.34 9.68e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg17340268 chr14:105411764 AHNAK2 0.5 6.7 0.38 1.25e-10 Rheumatoid arthritis; CESC cis rs9811920 0.638 rs2452321 chr3:99638836 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -5.38 -0.31 1.67e-7 Axial length; CESC trans rs853679 0.546 rs34371502 chr6:28081758 T/C cg06606381 chr12:133084897 FBRSL1 -1.1 -8.36 -0.46 3.51e-15 Depression; CESC cis rs10751667 0.600 rs14346 chr11:1011829 T/C cg20946044 chr11:1010712 AP2A2 -0.48 -6.33 -0.36 1.04e-9 Alzheimer's disease (late onset); CESC cis rs6582630 0.555 rs2090785 chr12:38424342 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.0 0.35 6.56e-9 Drug-induced liver injury (flucloxacillin); CESC trans rs11098499 0.657 rs71614442 chr4:120379346 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.86 0.52 9.48e-20 Corneal astigmatism; CESC cis rs1003719 0.788 rs9977602 chr21:38450650 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.64 0.47 5.56e-16 Eye color traits; CESC cis rs6547741 0.904 rs2384628 chr2:27774702 T/G cg21248554 chr2:27665150 KRTCAP3 0.25 5.16 0.3 4.77e-7 Oral cavity cancer; CESC cis rs7208859 0.524 rs28760584 chr17:29141017 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6982240 0.514 rs1865247 chr8:142274654 A/T cg00131261 chr8:142287264 NA -0.53 -7.28 -0.41 3.72e-12 Tonsillectomy; CESC cis rs6964587 1.000 rs36021614 chr7:91717490 C/G cg01689657 chr7:91764605 CYP51A1 0.28 5.12 0.3 5.88e-7 Breast cancer; CESC cis rs1692580 0.774 rs10797416 chr1:2182342 T/C cg04315214 chr1:2043799 PRKCZ -0.36 -5.09 -0.3 6.87e-7 Coronary artery disease; CESC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg25985355 chr7:65971099 NA 0.32 5.26 0.31 2.95e-7 Aortic root size; CESC trans rs79976124 0.760 rs74295030 chr6:66654441 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 8.75 0.47 2.61e-16 Type 2 diabetes; CESC cis rs595982 0.527 rs12151238 chr19:49368613 T/C cg15549821 chr19:49342101 PLEKHA4 -0.71 -7.97 -0.44 4.79e-14 Red cell distribution width; CESC cis rs763014 0.898 rs1981484 chr16:630710 A/G cg09263875 chr16:632152 PIGQ 0.67 11.14 0.56 6.6e-24 Height; CESC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg05863683 chr7:1912471 MAD1L1 0.36 5.35 0.31 1.86e-7 Bipolar disorder and schizophrenia; CESC cis rs1865721 0.771 rs724764 chr18:73139742 C/T cg26385618 chr18:73139727 C18orf62 -0.53 -8.6 -0.47 7.15e-16 Intelligence; CESC cis rs2075371 0.579 rs11766422 chr7:134018160 T/C cg20476274 chr7:133979776 SLC35B4 0.58 7.78 0.43 1.64e-13 Mean platelet volume; CESC cis rs344364 0.511 rs2906912 chr16:1953151 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.53 -5.94 -0.34 9.01e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg05343316 chr1:45956843 TESK2 -0.5 -6.41 -0.37 6.55e-10 High light scatter reticulocyte count; CESC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg02569458 chr12:86230093 RASSF9 0.5 7.53 0.42 7.91e-13 Major depressive disorder; CESC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg19046167 chr17:80928561 B3GNTL1 0.46 5.58 0.32 5.84e-8 Glycated hemoglobin levels; CESC cis rs9486719 1.000 rs9373978 chr6:97056255 T/C cg06623918 chr6:96969491 KIAA0776 -0.82 -8.4 -0.46 2.77e-15 Migraine;Coronary artery disease; CESC cis rs12497850 0.966 rs6792510 chr3:48723302 G/C cg06212747 chr3:49208901 KLHDC8B 0.61 7.79 0.43 1.48e-13 Parkinson's disease; CESC cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg16339924 chr4:17578868 LAP3 0.59 7.4 0.41 1.83e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1050631 0.657 rs1789551 chr18:33716092 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.51e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg19622623 chr12:86230825 RASSF9 0.47 6.01 0.35 6.16e-9 Major depressive disorder; CESC cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7640424 0.929 rs17828045 chr3:107821546 A/C cg09227934 chr3:107805635 CD47 -0.42 -5.68 -0.33 3.6e-8 Body mass index; CESC cis rs2228479 0.850 rs11076624 chr16:89855749 T/C cg19635926 chr16:89946313 TCF25 0.67 5.08 0.3 7.19e-7 Skin colour saturation; CESC cis rs6089584 1.000 rs6142910 chr20:60562181 C/A cg24733560 chr20:60626293 TAF4 0.4 5.77 0.33 2.15e-8 Body mass index; CESC cis rs7927771 0.524 rs11039431 chr11:47872012 G/T cg20307385 chr11:47447363 PSMC3 0.62 8.75 0.47 2.56e-16 Subjective well-being; CESC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg22535103 chr8:58192502 C8orf71 -1.06 -13.3 -0.63 2.88e-31 Developmental language disorder (linguistic errors); CESC cis rs68170813 0.599 rs11769901 chr7:106958505 G/A cg02696742 chr7:106810147 HBP1 -0.53 -5.04 -0.3 8.64e-7 Coronary artery disease; CESC cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg15017067 chr4:17643749 FAM184B 0.39 5.46 0.32 1.07e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs933688 1.000 rs60513756 chr5:90727692 A/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.12 12.34 0.6 6.14e-28 Smoking behavior; CESC cis rs2239547 0.657 rs13072536 chr3:52861211 A/T cg11645453 chr3:52864694 ITIH4 0.32 5.89 0.34 1.15e-8 Schizophrenia; CESC cis rs7520050 0.966 rs61783200 chr1:46297403 T/C cg24296786 chr1:45957014 TESK2 0.42 5.39 0.31 1.6e-7 Red blood cell count;Reticulocyte count; CESC cis rs17854409 0.803 rs3210314 chr20:61472117 C/A cg05147244 chr20:61493195 TCFL5 0.97 6.5 0.37 4e-10 Obesity-related traits; CESC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.68 0.47 4.07e-16 Menopause (age at onset); CESC cis rs116095464 0.558 rs9312978 chr5:221930 C/G cg22496380 chr5:211416 CCDC127 -0.96 -10.08 -0.53 1.95e-20 Breast cancer; CESC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg05604112 chr2:38893237 GALM -0.53 -6.98 -0.39 2.36e-11 5-HTT brain serotonin transporter levels; CESC cis rs3785574 0.743 rs2727334 chr17:61969063 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 7.37 0.41 2.17e-12 Height; CESC cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01021483 chr22:35820284 MCM5 0.45 6.43 0.37 6.07e-10 Fibrinogen levels; CESC cis rs2235544 0.579 rs1537323 chr1:54482523 G/T cg09175620 chr1:54484536 LDLRAD1 0.29 5.17 0.3 4.53e-7 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs34779708 0.966 rs34605125 chr10:35411246 A/G cg04310649 chr10:35416472 CREM -0.52 -6.23 -0.36 1.85e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs739401 0.572 rs739399 chr11:3016452 A/G cg08508325 chr11:3079039 CARS -0.54 -10.51 -0.54 7.98e-22 Longevity; CESC cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg03433033 chr1:76189801 ACADM 0.59 5.67 0.33 3.67e-8 Blood metabolite levels;Acylcarnitine levels; CESC trans rs1728785 0.818 rs1814299 chr16:68581332 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs7772486 0.719 rs4391282 chr6:146276780 A/T cg05347473 chr6:146136440 FBXO30 -0.52 -6.75 -0.38 9.24e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7394190 0.748 rs12573448 chr10:75504512 T/G cg07699608 chr10:75541558 CHCHD1 0.64 5.21 0.3 3.8e-7 Incident atrial fibrillation; CESC cis rs7130144 0.541 rs7936388 chr11:130462511 T/C cg26307797 chr11:130446613 NA -0.76 -6.78 -0.38 7.92e-11 Urate levels in lean individuals; CESC cis rs11608355 0.521 rs7972346 chr12:109808771 C/G cg19025524 chr12:109796872 NA 0.5 7.3 0.41 3.27e-12 Neuroticism; CESC cis rs3617 0.625 rs3774364 chr3:52863605 G/A cg07507251 chr3:52567010 NT5DC2 0.33 5.79 0.34 1.96e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs1986734 0.576 rs4493564 chr4:77420407 A/G cg20311846 chr4:77356250 SHROOM3 -0.28 -5.68 -0.33 3.62e-8 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC cis rs7188697 0.922 rs9923491 chr16:58603176 T/G cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC cis rs6430585 0.583 rs12373779 chr2:136586840 A/C cg07169764 chr2:136633963 MCM6 1.26 18.12 0.74 2.76e-48 Corneal structure; CESC cis rs4253772 0.513 rs9306512 chr22:46716603 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.77 9.33 0.5 4.27e-18 LDL cholesterol;Cholesterol, total; CESC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg04944784 chr2:26401820 FAM59B -0.9 -10.54 -0.54 6.5e-22 Gut microbiome composition (summer); CESC cis rs2404602 0.552 rs11630185 chr15:76959783 A/T cg06336613 chr15:77223807 RCN2 0.44 5.42 0.32 1.37e-7 Blood metabolite levels; CESC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg12311346 chr5:56204834 C5orf35 -0.74 -8.76 -0.47 2.43e-16 Initial pursuit acceleration; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg26708280 chr2:190649305 PMS1;ORMDL1 -0.51 -7.39 -0.41 1.98e-12 Vertical cup-disc ratio; CESC cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg24496475 chr4:1400189 NA 0.33 5.05 0.3 8.4e-7 Obesity-related traits; CESC cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC cis rs4253772 0.591 rs11703245 chr22:46684890 A/G cg18190219 chr22:46762943 CELSR1 -0.58 -5.33 -0.31 2.14e-7 LDL cholesterol;Cholesterol, total; CESC cis rs897984 0.762 rs4889604 chr16:30985994 G/T cg02466173 chr16:30829666 NA 0.48 7.99 0.44 4.09e-14 Dementia with Lewy bodies; CESC cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg26597838 chr10:835615 NA -0.75 -7.28 -0.41 3.88e-12 Eosinophil percentage of granulocytes; CESC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg02269571 chr22:50332266 NA -0.58 -7.2 -0.4 6.05e-12 Schizophrenia; CESC cis rs6963495 0.745 rs56239334 chr7:105165351 G/A cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs1003719 0.751 rs10154032 chr21:38453459 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.67 0.47 4.41e-16 Eye color traits; CESC cis rs644799 0.511 rs1016030 chr11:95472693 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.46 5.88 0.34 1.25e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg11644478 chr21:40555479 PSMG1 -0.55 -7.38 -0.41 2.08e-12 Menarche (age at onset); CESC cis rs55794721 0.509 rs2375313 chr1:25748235 G/A cg12412775 chr1:25698385 RHCE -0.29 -5.21 -0.3 3.87e-7 Plateletcrit;Mean corpuscular volume; CESC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg06634786 chr22:41940651 POLR3H -0.72 -7.51 -0.42 9.19e-13 Vitiligo; CESC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -8.3 -0.45 5.44e-15 Alzheimer's disease; CESC cis rs360071 0.528 rs360097 chr1:226065755 C/A cg17950169 chr1:226067900 TMEM63A 0.4 6.06 0.35 4.65e-9 Response to radiotherapy in prostate cancer (toxicity, rectal bleeding); CESC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg05457628 chr5:178986728 RUFY1 -0.55 -8.4 -0.46 2.75e-15 Lung cancer; CESC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg03806693 chr22:41940476 POLR3H 1.16 13.59 0.64 2.85e-32 Vitiligo; CESC cis rs2456568 0.548 rs10466334 chr11:93663512 A/G cg26875233 chr11:93583750 C11orf90 -0.32 -5.81 -0.34 1.77e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg13114125 chr14:105738426 BRF1 -0.9 -11.23 -0.57 3.37e-24 Mean platelet volume;Platelet distribution width; CESC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg16680214 chr1:154839983 KCNN3 -0.52 -8.09 -0.45 2.12e-14 Prostate cancer; CESC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg26335602 chr6:28129616 ZNF389 -0.47 -6.02 -0.35 5.75e-9 Parkinson's disease; CESC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg06221963 chr1:154839813 KCNN3 0.66 11.67 0.58 1.11e-25 Prostate cancer; CESC cis rs10214930 0.697 rs7806169 chr7:27907593 A/G cg05786569 chr7:27702416 HIBADH -0.44 -5.3 -0.31 2.42e-7 Hypospadias; CESC cis rs12950390 0.853 rs4793647 chr17:45854090 G/C cg00777063 chr17:45855553 NA -0.39 -5.74 -0.33 2.62e-8 IgG glycosylation; CESC cis rs2066819 0.818 rs773652 chr12:56674766 G/A cg26734620 chr12:56694298 CS -0.93 -9.55 -0.51 9.4e-19 Psoriasis vulgaris; CESC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg18876405 chr7:65276391 NA 0.7 9.83 0.52 1.18e-19 Calcium levels; CESC cis rs3749237 0.555 rs7637665 chr3:49552295 T/C cg07636037 chr3:49044803 WDR6 0.6 8.77 0.47 2.16e-16 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22068044 chr9:140095070 C9orf75 0.6 7.31 0.41 3.23e-12 Gut microbiome composition (summer); CESC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg24675658 chr1:53192096 ZYG11B 0.56 6.99 0.39 2.2e-11 Monocyte count; CESC cis rs4654899 0.758 rs6694455 chr1:21352185 C/T cg05370193 chr1:21551575 ECE1 0.37 5.65 0.33 4.12e-8 Superior frontal gyrus grey matter volume; CESC cis rs926938 0.765 rs2268701 chr1:115233046 C/T cg12756093 chr1:115239321 AMPD1 -0.59 -8.98 -0.48 5.08e-17 Autism; CESC cis rs2760061 0.626 rs1636192 chr1:228124688 A/G cg02753203 chr1:228287806 NA -0.5 -7.22 -0.41 5.36e-12 Diastolic blood pressure; CESC cis rs7296418 0.663 rs11057276 chr12:123820397 C/T cg05973401 chr12:123451056 ABCB9 -0.4 -5.19 -0.3 4.2e-7 Platelet count; CESC cis rs3749237 0.595 rs4855877 chr3:49448527 T/C cg02487422 chr3:49467188 NICN1 0.54 7.77 0.43 1.74e-13 Resting heart rate; CESC trans rs10435719 0.809 rs77601743 chr8:11790569 G/A cg15556689 chr8:8085844 FLJ10661 0.52 6.36 0.36 8.63e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs9467711 0.606 rs9393715 chr6:26375645 G/A cg14345882 chr6:26364793 BTN3A2 0.61 6.06 0.35 4.73e-9 Autism spectrum disorder or schizophrenia; CESC cis rs71403859 0.502 rs12927006 chr16:71549911 A/G cg08717414 chr16:71523259 ZNF19 -1.04 -9.94 -0.52 5.46e-20 Post bronchodilator FEV1; CESC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg06420487 chr17:61919686 SMARCD2 0.45 5.36 0.31 1.82e-7 Height; CESC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.39e-11 Developmental language disorder (linguistic errors); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg23147149 chr17:2304328 MNT 0.48 6.0 0.35 6.51e-9 Tetralogy of Fallot; CESC cis rs1045714 1.000 rs1045713 chr7:2653579 G/A cg20813462 chr7:2646259 IQCE 0.71 5.79 0.34 1.98e-8 Urate levels in lean individuals; CESC cis rs1665050 0.625 rs8028764 chr15:59304635 C/T cg05156742 chr15:59063176 FAM63B 0.41 5.14 0.3 5.4e-7 Atopic dermatitis; CESC cis rs2180341 0.781 rs6913350 chr6:127570560 C/T cg27446573 chr6:127587934 RNF146 0.82 11.68 0.58 1.09e-25 Breast cancer; CESC cis rs1348850 0.958 rs1405713 chr2:178461560 G/C cg23306229 chr2:178417860 TTC30B 0.57 7.52 0.42 8.3e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg25036284 chr2:26402008 FAM59B -0.83 -9.55 -0.51 8.86e-19 Gut microbiome composition (summer); CESC cis rs8067545 0.611 rs2703775 chr17:20134466 A/G cg13482628 chr17:19912719 NA -0.42 -5.64 -0.33 4.25e-8 Schizophrenia; CESC cis rs7927592 0.956 rs7944870 chr11:68309108 C/G cg20283391 chr11:68216788 NA -0.53 -6.36 -0.36 8.74e-10 Total body bone mineral density; CESC cis rs8114671 0.869 rs2145559 chr20:33651725 G/A cg06115741 chr20:33292138 TP53INP2 -0.46 -5.46 -0.32 1.08e-7 Height; CESC cis rs2197308 0.765 rs11182434 chr12:37923968 C/A cg13010199 chr12:38710504 ALG10B 0.53 6.76 0.38 8.79e-11 Morning vs. evening chronotype; CESC cis rs829883 0.659 rs4762495 chr12:98934105 C/T cg25150519 chr12:98850993 NA -0.64 -7.87 -0.44 8.8e-14 Colorectal adenoma (advanced); CESC cis rs4566357 0.595 rs10201538 chr2:227914449 A/G cg11843606 chr2:227700838 RHBDD1 -0.46 -6.28 -0.36 1.38e-9 Coronary artery disease; CESC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg14393609 chr7:65229607 NA 0.47 6.33 0.36 1.01e-9 Aortic root size; CESC trans rs12659622 0.703 rs74655962 chr5:15680745 G/A cg08701621 chr19:58570419 ZNF135 -0.55 -6.1 -0.35 3.65e-9 Obesity-related traits; CESC trans rs79976124 0.800 rs12194767 chr6:66639599 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.69 8.08 0.44 2.23e-14 Type 2 diabetes; CESC cis rs12155623 0.619 rs11775403 chr8:49877323 A/T cg00325661 chr8:49890786 NA 0.41 5.64 0.33 4.34e-8 Sudden cardiac arrest; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12044889 chr6:3000430 NQO2 -0.45 -6.48 -0.37 4.57e-10 Gambling; CESC cis rs10791097 0.629 rs11222361 chr11:130731424 T/G cg12179176 chr11:130786555 SNX19 0.56 8.16 0.45 1.36e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08660999 chr19:1592898 MBD3 0.55 6.47 0.37 4.66e-10 Gut microbiome composition (summer); CESC cis rs738322 0.718 rs2899297 chr22:38594668 A/G cg17652424 chr22:38574118 PLA2G6 -0.32 -5.53 -0.32 7.64e-8 Cutaneous nevi; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg22568695 chr18:59888119 KIAA1468 0.4 6.34 0.36 9.91e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs57024841 0.562 rs7862602 chr9:139840471 G/T cg00693599 chr9:139836323 FBXW5 0.46 6.74 0.38 1e-10 Beta-trace protein levels; CESC cis rs4853525 0.522 rs62179717 chr2:191590813 T/G cg10560079 chr2:191398806 TMEM194B -0.47 -5.91 -0.34 1.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; CESC cis rs2573652 0.963 rs2573649 chr15:100514040 C/G cg00587665 chr15:100533223 ADAMTS17 -0.32 -5.15 -0.3 5.13e-7 Height; CESC cis rs734999 0.588 rs876938 chr1:2523212 G/C cg20673091 chr1:2541236 MMEL1 0.43 6.85 0.39 5.3e-11 Ulcerative colitis; CESC cis rs1348850 0.651 rs1901826 chr2:178225266 G/A cg22681709 chr2:178499509 PDE11A -0.36 -5.42 -0.32 1.31e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8038465 0.592 rs899981 chr15:73935329 G/A cg15420318 chr15:73925796 NPTN 0.49 7.03 0.4 1.77e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs13102973 0.965 rs11731021 chr4:135850391 G/T cg14419869 chr4:135874104 NA 0.33 5.19 0.3 4.29e-7 Subjective well-being; CESC cis rs7666738 0.830 rs1813972 chr4:98886828 C/A cg05340658 chr4:99064831 C4orf37 0.73 10.55 0.54 5.89e-22 Colonoscopy-negative controls vs population controls; CESC cis rs10465746 0.780 rs1871924 chr1:84398466 T/A cg10977910 chr1:84465055 TTLL7 0.52 7.14 0.4 9.05e-12 Obesity-related traits; CESC cis rs7116495 1.000 rs12283462 chr11:71835406 T/G cg10381502 chr11:71823885 C11orf51 0.72 5.91 0.34 1.05e-8 Severe influenza A (H1N1) infection; CESC cis rs11098499 0.863 rs9997631 chr4:120469995 C/G cg09307838 chr4:120376055 NA 0.9 12.5 0.61 1.67e-28 Corneal astigmatism; CESC cis rs72781680 0.611 rs72783636 chr2:24328706 C/T cg06627628 chr2:24431161 ITSN2 -0.68 -6.58 -0.37 2.44e-10 Lymphocyte counts; CESC cis rs12971120 0.947 rs34676212 chr18:72170006 A/G cg26446133 chr18:72167187 CNDP2 -0.77 -11.45 -0.58 6.12e-25 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27633877 chr2:109329328 NA -0.53 -6.25 -0.36 1.6e-9 Gut microbiome composition (summer); CESC cis rs2370759 1.000 rs2370759 chr10:32634972 G/A cg01819863 chr10:32635814 EPC1 1.16 12.73 0.62 2.71e-29 Sexual dysfunction (female); CESC cis rs2011503 1.000 rs77616520 chr19:19652776 G/A cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs8180040 0.934 rs12630641 chr3:47534836 G/T cg27129171 chr3:47204927 SETD2 0.6 8.92 0.48 7.91e-17 Colorectal cancer; CESC cis rs3812762 0.783 rs34524863 chr11:8777408 T/C cg03980550 chr11:8754370 ST5 -0.41 -5.65 -0.33 4.08e-8 Hypospadias; CESC cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg03433033 chr1:76189801 ACADM -0.65 -7.61 -0.42 4.81e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9905704 0.881 rs302846 chr17:56687536 T/A cg12560992 chr17:57184187 TRIM37 0.62 7.73 0.43 2.17e-13 Testicular germ cell tumor; CESC cis rs796364 0.806 rs55985986 chr2:201120987 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -6.44 -0.37 5.68e-10 Schizophrenia; CESC cis rs4660306 1.000 rs2356561 chr1:45980862 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.51 -6.58 -0.37 2.54e-10 Homocysteine levels; CESC trans rs7582180 0.700 rs1437971 chr2:100986964 A/C cg03343534 chr8:117778609 UTP23 0.63 6.39 0.37 7.44e-10 Intelligence (multi-trait analysis); CESC cis rs10751667 0.643 rs10794350 chr11:946070 A/G cg20946044 chr11:1010712 AP2A2 -0.42 -5.72 -0.33 2.9e-8 Alzheimer's disease (late onset); CESC cis rs7953249 0.618 rs7954331 chr12:121398657 G/T cg25281562 chr12:121454272 C12orf43 -0.46 -5.7 -0.33 3.12e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg27170947 chr2:26402098 FAM59B -0.87 -9.89 -0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs763121 0.626 rs5750643 chr22:39009017 A/G cg06544989 chr22:39130855 UNC84B 0.51 9.26 0.49 7.17e-18 Menopause (age at onset); CESC cis rs7818345 0.967 rs7015440 chr8:19276991 A/G cg11303988 chr8:19266685 CSGALNACT1 0.32 5.85 0.34 1.45e-8 Language performance in older adults (adjusted for episodic memory); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20982311 chr1:9489248 NA 0.64 7.23 0.41 5.18e-12 Gut microbiome composition (summer); CESC cis rs7927592 0.913 rs7107622 chr11:68374183 T/C cg20283391 chr11:68216788 NA -0.47 -5.7 -0.33 3.12e-8 Total body bone mineral density; CESC cis rs12618769 0.543 rs56357378 chr2:99032455 T/G cg10123293 chr2:99228465 UNC50 0.4 5.32 0.31 2.21e-7 Bipolar disorder; CESC cis rs6831352 0.918 rs17218602 chr4:100061073 A/G cg13256891 chr4:100009986 ADH5 -0.75 -8.21 -0.45 9.89e-15 Alcohol dependence; CESC trans rs875971 0.660 rs801193 chr7:66030612 A/C cg26939375 chr7:64535504 NA -0.67 -9.27 -0.49 6.86e-18 Aortic root size; CESC cis rs10754283 0.901 rs10922684 chr1:90117934 T/C cg21401794 chr1:90099060 LRRC8C 0.67 9.08 0.49 2.59e-17 Amyotrophic lateral sclerosis (sporadic); CESC cis rs4242434 0.927 rs3736147 chr8:22471824 A/G cg03733263 chr8:22462867 KIAA1967 -0.92 -14.09 -0.65 5.02e-34 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg08736216 chr1:53307985 ZYG11A -0.44 -7.61 -0.42 4.91e-13 Monocyte count; CESC cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg24642844 chr7:1081250 C7orf50 -0.73 -8.84 -0.48 1.36e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9325144 0.560 rs2013804 chr12:38631079 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.05 -0.35 4.95e-9 Morning vs. evening chronotype; CESC cis rs832540 0.519 rs6895442 chr5:56260998 T/C cg14703610 chr5:56206110 C5orf35 0.5 6.54 0.37 3.21e-10 Coronary artery disease; CESC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg16545954 chr1:2118288 C1orf86 -0.36 -7.21 -0.4 5.92e-12 Height; CESC cis rs2439831 0.850 rs2439832 chr15:43779686 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.47 0.54 1.1e-21 Lung cancer in ever smokers; CESC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg05564831 chr3:52568323 NT5DC2 0.48 7.58 0.42 5.66e-13 Bipolar disorder; CESC cis rs61542988 0.797 rs4329182 chr7:22882621 C/T cg11367502 chr7:22862612 TOMM7 0.48 5.98 0.34 7.09e-9 Fibrinogen levels; CESC cis rs10203711 0.966 rs907105 chr2:239565052 A/G cg14580085 chr2:239553406 NA 0.34 5.16 0.3 4.74e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs6866344 0.570 rs1132338 chr5:178139442 T/G cg10224037 chr5:178157518 ZNF354A 0.73 8.63 0.47 5.77e-16 Neutrophil percentage of white cells; CESC cis rs73019876 0.869 rs812673 chr19:22122335 C/T cg11619707 chr19:22235551 ZNF257 -0.29 -5.37 -0.31 1.72e-7 Testicular germ cell tumor; CESC cis rs4835473 0.932 rs1849113 chr4:144883665 C/T cg25736465 chr4:144833511 NA -0.41 -5.65 -0.33 4.08e-8 Immature fraction of reticulocytes; CESC cis rs7000551 0.751 rs2449329 chr8:22374794 G/T cg12081754 chr8:22256438 SLC39A14 0.4 5.39 0.31 1.55e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19089314 chr22:50919938 ADM2 -0.5 -6.35 -0.36 9.18e-10 Ulcerative colitis; CESC cis rs12931792 0.712 rs4787495 chr16:30165725 C/T cg17640201 chr16:30407289 ZNF48 -0.56 -7.75 -0.43 1.98e-13 Tonsillectomy; CESC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs9911578 0.813 rs8066773 chr17:56601552 A/G cg12560992 chr17:57184187 TRIM37 0.87 12.6 0.61 7.81e-29 Intelligence (multi-trait analysis); CESC cis rs11638352 0.661 rs1426657 chr15:44434529 A/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -5.29 -0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg19626725 chr5:178986131 RUFY1 -0.4 -6.52 -0.37 3.57e-10 Lung cancer; CESC cis rs6460942 0.591 rs10262667 chr7:12385391 C/T cg20607287 chr7:12443886 VWDE -0.55 -7.85 -0.43 1.05e-13 Coronary artery disease; CESC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg14773178 chr5:1868261 NA 0.32 5.76 0.33 2.31e-8 Cardiovascular disease risk factors; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21881364 chr11:72438004 ARAP1 0.45 6.01 0.35 6.2e-9 Fibrinogen levels; CESC cis rs7635838 0.650 rs1375206 chr3:11339117 C/G cg00170343 chr3:11313890 ATG7 0.54 7.77 0.43 1.71e-13 HDL cholesterol; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20696051 chr7:158649028 WDR60 -0.45 -6.02 -0.35 5.81e-9 Height; CESC cis rs3820928 0.845 rs13419076 chr2:227873028 A/G cg11843606 chr2:227700838 RHBDD1 -0.47 -6.05 -0.35 4.92e-9 Pulmonary function; CESC cis rs8180040 0.966 rs11925823 chr3:47443065 C/G cg27129171 chr3:47204927 SETD2 0.63 9.65 0.51 4.34e-19 Colorectal cancer; CESC trans rs7618501 0.966 rs7372966 chr3:49788969 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -8.49 -0.46 1.55e-15 Intelligence (multi-trait analysis); CESC trans rs35110281 0.627 rs56369437 chr21:44970275 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 7.03 0.4 1.8e-11 Mean corpuscular volume; CESC cis rs7937682 0.889 rs567859 chr11:111486738 A/G cg22437258 chr11:111473054 SIK2 0.72 9.66 0.51 4.24e-19 Primary sclerosing cholangitis; CESC cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.619 rs1101727 chr17:18016148 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.62 8.59 0.47 7.7e-16 Total body bone mineral density; CESC cis rs9596863 1.000 rs9596860 chr13:54431215 G/A ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs1801251 0.778 rs2592115 chr2:233736349 C/T cg08000102 chr2:233561755 GIGYF2 -0.61 -8.67 -0.47 4.44e-16 Coronary artery disease; CESC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.8 -0.34 1.84e-8 Total body bone mineral density; CESC cis rs9287719 0.934 rs6710033 chr2:10757677 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.67 -0.33 3.73e-8 Prostate cancer; CESC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg24250549 chr1:154909240 PMVK 0.62 8.37 0.46 3.3e-15 Prostate cancer; CESC cis rs6691722 0.503 rs2274168 chr1:24707211 G/T cg02336364 chr1:24764700 NIPAL3 0.32 6.58 0.37 2.48e-10 Response to interferon beta in multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20249169 chr2:64881356 SERTAD2 -0.7 -8.02 -0.44 3.39e-14 Gut microbiome composition (summer); CESC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg11987759 chr7:65425863 GUSB 0.48 6.51 0.37 3.76e-10 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17973565 chr1:153606594 C1orf77;S100A13 0.58 6.44 0.37 5.64e-10 Gut microbiome composition (summer); CESC cis rs7617773 0.817 rs6791930 chr3:48329900 A/G cg11946769 chr3:48343235 NME6 0.81 10.91 0.56 3.86e-23 Coronary artery disease; CESC cis rs11190604 1.000 rs10883503 chr10:102275504 C/A cg07080220 chr10:102295463 HIF1AN 0.67 6.12 0.35 3.3e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg03264133 chr6:25882463 NA -0.62 -9.43 -0.5 2.14e-18 Intelligence (multi-trait analysis); CESC cis rs8064299 0.560 rs11077763 chr17:72786029 T/C cg25054828 chr17:72772726 NAT9;TMEM104 0.82 13.87 0.65 3e-33 Monocyte count; CESC trans rs1814175 0.645 rs6486022 chr11:49776137 A/G cg03929089 chr4:120376271 NA -0.89 -13.67 -0.64 1.51e-32 Height; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02290708 chr21:35747831 FAM165B -0.44 -6.14 -0.35 2.99e-9 Asthma; CESC cis rs71403859 0.667 rs12920890 chr16:71787588 G/A cg08717414 chr16:71523259 ZNF19 -0.69 -5.77 -0.33 2.24e-8 Post bronchodilator FEV1; CESC cis rs35110281 0.748 rs162403 chr21:44963365 C/G cg04455712 chr21:45112962 RRP1B 0.37 5.42 0.32 1.35e-7 Mean corpuscular volume; CESC cis rs9987353 0.620 rs34455383 chr8:9066458 C/T cg06636001 chr8:8085503 FLJ10661 -0.59 -6.58 -0.37 2.47e-10 Recombination measurement; CESC cis rs9488822 0.676 rs13210143 chr6:116389636 G/A cg18764771 chr6:116381957 FRK 0.24 6.01 0.35 6.14e-9 Cholesterol, total;LDL cholesterol; CESC trans rs61931739 0.534 rs1608912 chr12:34008574 C/T cg26384229 chr12:38710491 ALG10B 0.46 6.31 0.36 1.17e-9 Morning vs. evening chronotype; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg10169971 chr6:83902988 RWDD2A;PGM3 -0.44 -6.31 -0.36 1.14e-9 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12457035 chr5:180688144 TRIM52 -0.44 -6.24 -0.36 1.71e-9 Fibrinogen levels; CESC cis rs1030877 1.000 rs1030877 chr2:105910513 G/A cg02079111 chr2:105885981 TGFBRAP1 0.63 9.92 0.52 6.12e-20 Obesity-related traits; CESC cis rs12478296 0.534 rs67092377 chr2:243002171 T/G cg06360820 chr2:242988706 NA -0.58 -7.58 -0.42 5.89e-13 Obesity-related traits; CESC cis rs7824557 0.767 rs1897950 chr8:11169551 C/A cg21775007 chr8:11205619 TDH 0.48 6.95 0.39 2.89e-11 Retinal vascular caliber; CESC cis rs7678296 0.730 rs1435385 chr4:37228506 C/G cg06805348 chr4:37245195 KIAA1239 0.42 5.05 0.3 8.22e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs7208859 0.623 rs57486336 chr17:29085731 G/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg17178900 chr1:205818956 PM20D1 0.38 5.25 0.31 3.19e-7 Prostate-specific antigen levels; CESC cis rs892961 0.932 rs3987887 chr17:75414862 T/C cg05865280 chr17:75406074 SEPT9 0.62 12.42 0.61 3.19e-28 Airflow obstruction; CESC cis rs7267979 0.816 rs404775 chr20:25481117 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.71 0.67 3.22e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs262150 0.522 rs2527182 chr7:158813812 A/G cg19418458 chr7:158789849 NA -0.41 -6.23 -0.36 1.81e-9 Facial morphology (factor 20); CESC cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg25019033 chr10:957182 NA 0.68 8.27 0.45 6.77e-15 Eosinophil percentage of granulocytes; CESC cis rs7584330 0.554 rs76408976 chr2:238384784 C/T cg14458575 chr2:238380390 NA 0.69 5.73 0.33 2.65e-8 Prostate cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19155557 chr3:41240643 CTNNB1 0.39 6.02 0.35 5.74e-9 Gambling; CESC cis rs6831352 0.734 rs12502237 chr4:100015675 G/A cg12011299 chr4:100065546 ADH4 0.57 6.92 0.39 3.46e-11 Alcohol dependence; CESC cis rs17253792 0.822 rs10483645 chr14:56103766 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.65 0.33 4.2e-8 Putamen volume; CESC cis rs2204008 0.870 rs12369578 chr12:38444227 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.9 0.34 1.1e-8 Bladder cancer; CESC cis rs9457247 1.000 rs10946198 chr6:167404432 C/T cg07741184 chr6:167504864 NA 0.28 5.1 0.3 6.54e-7 Crohn's disease; CESC cis rs250677 0.958 rs10056942 chr5:148416114 C/A cg18129178 chr5:148520854 ABLIM3 -0.52 -5.78 -0.33 2.05e-8 Breast cancer; CESC cis rs6582630 0.519 rs8189599 chr12:38280748 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.96 0.52 4.57e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs2289328 0.943 rs3803360 chr15:40662669 C/T cg13931752 chr15:40660718 DISP2 0.47 5.86 0.34 1.33e-8 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); CESC cis rs2072732 0.821 rs60287244 chr1:2943668 A/G cg03976712 chr1:2946727 NA 0.34 5.35 0.31 1.9e-7 Plateletcrit; CESC trans rs78049276 0.688 rs73855809 chr4:148380348 G/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.63 -6.69 -0.38 1.33e-10 Pulse pressure; CESC cis rs708547 0.874 rs1630798 chr4:57883558 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.56 -5.78 -0.33 2.06e-8 Response to bleomycin (chromatid breaks); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10864883 chr7:75943751 NA -0.49 -6.21 -0.36 2.07e-9 Asthma; CESC cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.87 0.34 1.28e-8 Tonsillectomy; CESC trans rs2727020 0.615 rs4980435 chr11:49591576 G/A cg15704280 chr7:45808275 SEPT13 -0.96 -17.09 -0.72 1.22e-44 Coronary artery disease; CESC cis rs4595586 0.566 rs11615585 chr12:39409351 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs7829975 0.514 rs2976926 chr8:8261624 T/C cg06636001 chr8:8085503 FLJ10661 0.53 6.97 0.39 2.48e-11 Mood instability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14029580 chr4:1363708 KIAA1530 -0.54 -6.18 -0.35 2.36e-9 Gut microbiome composition (summer); CESC cis rs2235642 0.891 rs2281231 chr16:1601879 A/G cg09080909 chr16:1797204 MAPK8IP3 -0.42 -6.01 -0.35 6.2e-9 Coronary artery disease; CESC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg11644478 chr21:40555479 PSMG1 1.01 16.84 0.72 9.25e-44 Cognitive function; CESC cis rs796364 0.806 rs6435041 chr2:200867144 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.87 7.76 0.43 1.81e-13 Schizophrenia; CESC cis rs7726839 0.561 rs72703058 chr5:584519 G/A cg16447950 chr5:562315 NA -0.55 -6.19 -0.36 2.29e-9 Obesity-related traits; CESC cis rs1580019 0.844 rs1037322 chr7:32501857 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.42 5.08 0.3 6.98e-7 Cognitive ability; CESC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg04317338 chr11:64019027 PLCB3 0.48 5.7 0.33 3.25e-8 Platelet count; CESC cis rs9837602 0.507 rs6803204 chr3:99680874 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.64 -10.1 -0.53 1.62e-20 Breast cancer; CESC cis rs636291 0.517 rs673254 chr1:10550352 C/T cg07384165 chr1:10488281 NA -0.58 -8.62 -0.47 6.26e-16 Prostate cancer; CESC cis rs524281 0.861 rs2293121 chr11:65961347 T/G cg14036092 chr11:66035641 RAB1B -0.61 -6.46 -0.37 5.06e-10 Electroencephalogram traits; CESC cis rs4948102 0.731 rs10229446 chr7:56064262 A/G cg09872392 chr7:56161020 PHKG1 0.46 7.35 0.41 2.42e-12 Plasma homocysteine levels (post-methionine load test); CESC trans rs61931739 0.500 rs10844846 chr12:34394611 C/G cg26384229 chr12:38710491 ALG10B 0.54 7.75 0.43 2.01e-13 Morning vs. evening chronotype; CESC cis rs17818399 0.926 rs35682608 chr2:46836542 A/T cg06386533 chr2:46925753 SOCS5 0.47 5.19 0.3 4.11e-7 Height; CESC cis rs13256369 0.789 rs13282500 chr8:8568489 A/T cg18904891 chr8:8559673 CLDN23 0.52 6.03 0.35 5.45e-9 Obesity-related traits; CESC cis rs11098499 0.954 rs10518328 chr4:120401779 G/A cg09307838 chr4:120376055 NA 0.93 13.07 0.63 1.85e-30 Corneal astigmatism; CESC cis rs12142240 0.698 rs68083747 chr1:46807416 T/G cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs1538970 0.884 rs61788261 chr1:45899114 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.45 0.32 1.14e-7 Platelet count; CESC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.18e-7 Aortic root size; CESC cis rs1322639 0.697 rs12661910 chr6:169584388 A/G cg03254818 chr6:169586852 NA 0.53 6.02 0.35 5.72e-9 Pulse pressure; CESC trans rs11039798 0.588 rs10160381 chr11:48599491 A/G cg15704280 chr7:45808275 SEPT13 0.6 6.24 0.36 1.69e-9 Axial length; CESC cis rs2228479 0.618 rs34689166 chr16:89860697 C/T cg04013166 chr16:89971882 TCF25 0.77 6.61 0.38 2.05e-10 Skin colour saturation; CESC cis rs8062405 1.000 rs8055982 chr16:28881202 A/C cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs61931739 0.749 rs7315233 chr12:34271975 G/T cg19457237 chr12:34500585 NA -0.41 -5.61 -0.33 5.17e-8 Morning vs. evening chronotype; CESC cis rs7671266 0.668 rs10002562 chr4:10159736 C/G cg11266682 chr4:10021025 SLC2A9 -0.48 -6.0 -0.35 6.29e-9 Cardiovascular disease risk factors; CESC cis rs2034088 0.897 rs11652657 chr17:439124 A/G cg06217071 chr17:408420 NA 0.5 9.67 0.51 3.82e-19 Hip circumference adjusted for BMI; CESC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg00166722 chr3:10149974 C3orf24 0.48 6.15 0.35 2.78e-9 Alzheimer's disease; CESC cis rs1707322 0.682 rs12041197 chr1:46104464 T/C cg03146154 chr1:46216737 IPP 0.81 11.48 0.58 5.05e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs5753618 0.583 rs9606843 chr22:31853371 A/C cg00478049 chr22:31556069 RNF185 -0.43 -5.12 -0.3 5.93e-7 Colorectal cancer; CESC cis rs1707322 0.647 rs6686944 chr1:46156308 G/T cg06784218 chr1:46089804 CCDC17 0.43 7.53 0.42 7.83e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg20271620 chr17:80763330 TBCD 0.43 5.12 0.3 5.78e-7 Breast cancer; CESC cis rs9583531 0.600 rs3809344 chr13:111358705 G/A cg24331049 chr13:111365604 ING1 0.75 10.98 0.56 2.28e-23 Coronary artery disease; CESC cis rs2742234 0.955 rs2503849 chr10:43672776 G/A cg07801480 chr10:43725741 RASGEF1A 0.38 5.35 0.31 1.86e-7 Hirschsprung disease; CESC cis rs6499255 0.951 rs11075728 chr16:69611582 A/G cg15192750 chr16:69999425 NA 0.53 6.19 0.36 2.31e-9 IgE levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg20526303 chr3:197676828 RPL35A;IQCG -0.47 -6.22 -0.36 1.89e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg21770322 chr7:97807741 LMTK2 0.55 8.28 0.45 5.99e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs963731 0.649 rs1470915 chr2:39247336 G/A cg04010122 chr2:39346883 SOS1 -0.73 -5.39 -0.31 1.54e-7 Corticobasal degeneration; CESC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg15112475 chr7:1198522 ZFAND2A -0.39 -6.2 -0.36 2.18e-9 Longevity;Endometriosis; CESC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg02018176 chr4:1364513 KIAA1530 0.41 5.47 0.32 1.06e-7 Longevity; CESC trans rs3780486 0.846 rs10124479 chr9:33136233 T/G cg04842962 chr6:43655489 MRPS18A 1.0 19.15 0.76 6.75e-52 IgG glycosylation; CESC cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.44 5.4 0.32 1.45e-7 Eosinophil percentage of white cells; CESC cis rs35306767 0.953 rs12762973 chr10:960761 C/G cg26597838 chr10:835615 NA 0.86 9.62 0.51 5.72e-19 Eosinophil percentage of granulocytes; CESC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.88 0.39 4.18e-11 Bipolar disorder; CESC cis rs7264396 0.676 rs6058383 chr20:34556005 T/C cg17201900 chr20:34330562 RBM39 0.5 5.22 0.31 3.71e-7 Total cholesterol levels; CESC cis rs16854884 0.657 rs2099543 chr3:143742164 C/T cg06585982 chr3:143692056 C3orf58 0.5 6.71 0.38 1.18e-10 Economic and political preferences (feminism/equality); CESC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg11764359 chr7:65958608 NA -0.8 -12.02 -0.59 7.52e-27 Aortic root size; CESC cis rs1395 0.778 rs2580761 chr2:27426362 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 5.85 0.34 1.44e-8 Blood metabolite levels; CESC cis rs9325144 0.560 rs7971313 chr12:38653413 A/G cg13010199 chr12:38710504 ALG10B -0.45 -6.1 -0.35 3.79e-9 Morning vs. evening chronotype; CESC cis rs7429990 0.965 rs4858880 chr3:48104449 C/A cg11946769 chr3:48343235 NME6 -0.44 -5.36 -0.31 1.8e-7 Educational attainment (years of education); CESC cis rs9549260 0.755 rs1413482 chr13:41218451 C/T cg21288729 chr13:41239152 FOXO1 0.67 8.78 0.47 2.01e-16 Red blood cell count; CESC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg17372223 chr3:52568218 NT5DC2 0.41 5.69 0.33 3.28e-8 Bipolar disorder; CESC cis rs17376456 0.877 rs13156865 chr5:93390908 C/A cg21475434 chr5:93447410 FAM172A 0.77 6.96 0.39 2.61e-11 Diabetic retinopathy; CESC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg00484396 chr16:3507460 NAT15 -0.58 -6.29 -0.36 1.32e-9 Tuberculosis; CESC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12681288 0.823 rs2701908 chr8:1003250 T/C cg04851639 chr8:1020857 NA -0.35 -7.79 -0.43 1.54e-13 Schizophrenia; CESC cis rs2425143 0.908 rs75331436 chr20:34391052 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 7.72e-12 Blood protein levels; CESC cis rs807669 0.548 rs762522 chr22:19180575 C/T cg02655711 chr22:19163373 SLC25A1 0.75 11.77 0.59 5.32e-26 Metabolite levels; CESC cis rs1707322 0.716 rs28375469 chr1:46195375 T/C cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg06212747 chr3:49208901 KLHDC8B 0.76 10.35 0.54 2.7e-21 Parkinson's disease; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg25263898 chr1:36774223 C1orf113 -0.49 -6.51 -0.37 3.76e-10 Breast cancer;Type 2 diabetes; CESC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg17366294 chr4:99064904 C4orf37 -0.59 -7.69 -0.43 2.81e-13 Colonoscopy-negative controls vs population controls; CESC cis rs4704187 0.649 rs58999738 chr5:74545798 A/G cg03227963 chr5:74354835 NA 0.28 5.27 0.31 2.86e-7 Response to amphetamines; CESC cis rs2658782 0.756 rs2658777 chr11:93148423 C/T cg15737290 chr11:93063684 CCDC67 0.49 5.94 0.34 8.92e-9 Pulmonary function decline; CESC cis rs1023500 0.551 rs2859438 chr22:42466980 A/T cg15557168 chr22:42548783 NA -0.44 -6.12 -0.35 3.35e-9 Schizophrenia; CESC cis rs2731664 0.792 rs337374 chr5:176890416 A/G cg23176889 chr5:176863531 GRK6 0.64 11.63 0.58 1.59e-25 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21810621 chr11:1331345 LOC255512;TOLLIP 0.6 7.05 0.4 1.56e-11 Gut microbiome composition (summer); CESC cis rs611744 0.839 rs638238 chr8:109169152 A/G cg21045802 chr8:109455806 TTC35 0.46 5.56 0.32 6.54e-8 Dupuytren's disease; CESC cis rs1707322 0.963 rs4459051 chr1:46451203 A/G cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7267979 0.565 rs958075 chr20:25595123 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.72 -12.01 -0.59 8.11e-27 Liver enzyme levels (alkaline phosphatase); CESC cis rs12824058 0.831 rs11608406 chr12:130805866 G/C cg23887609 chr12:130822674 PIWIL1 0.43 5.49 0.32 9.43e-8 Menopause (age at onset); CESC cis rs11031096 0.711 rs11031156 chr11:4179021 C/T cg18678763 chr11:4115507 RRM1 -0.43 -5.95 -0.34 8.38e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs10088262 0.629 rs7828192 chr8:124804669 C/T cg15047889 chr8:124780837 FAM91A1 -0.51 -6.37 -0.36 8.14e-10 Pancreatic cancer; CESC cis rs3617 0.625 rs11715347 chr3:52883070 C/T cg07507251 chr3:52567010 NT5DC2 -0.32 -5.47 -0.32 1.03e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs6439153 0.901 rs2630263 chr3:128688318 A/G cg25356066 chr3:128598488 ACAD9 0.53 6.93 0.39 3.19e-11 Pneumococcal bacteremia; CESC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg09658497 chr7:2847517 GNA12 -0.37 -5.22 -0.31 3.56e-7 Height; CESC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg11987759 chr7:65425863 GUSB 0.45 6.07 0.35 4.35e-9 Aortic root size; CESC cis rs1878931 0.726 rs3843728 chr16:3448251 T/C cg21433313 chr16:3507492 NAT15 -0.38 -5.64 -0.33 4.25e-8 Body mass index (adult); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10624161 chr6:107349251 C6orf203 0.55 6.73 0.38 1.02e-10 Gut microbiome composition (summer); CESC cis rs13082711 0.595 rs6778612 chr3:27370789 T/C cg02860705 chr3:27208620 NA -0.63 -7.86 -0.43 9.88e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg09365446 chr1:150670422 GOLPH3L 0.4 5.26 0.31 3.02e-7 Melanoma; CESC cis rs7178909 0.872 rs28865973 chr15:90435178 T/G cg19708238 chr15:90437601 AP3S2 0.43 6.13 0.35 3.11e-9 Common traits (Other); CESC cis rs751728 0.638 rs4607416 chr6:33784998 G/C cg25922239 chr6:33757077 LEMD2 0.41 5.21 0.3 3.88e-7 Crohn's disease; CESC cis rs3741489 1.000 rs2062161 chr12:133428032 G/A cg01499426 chr12:133417423 CHFR 0.9 5.59 0.32 5.77e-8 Cognitive function; CESC cis rs7020830 0.898 rs12555207 chr9:37315476 C/T cg14294708 chr9:37120828 ZCCHC7 1.1 18.59 0.75 6.22e-50 Schizophrenia; CESC cis rs8067545 0.611 rs2703781 chr17:20144714 A/G cg13482628 chr17:19912719 NA -0.41 -5.51 -0.32 8.66e-8 Schizophrenia; CESC cis rs2404602 0.536 rs11072599 chr15:76774508 T/C cg26408565 chr15:76604113 ETFA -0.43 -6.4 -0.37 7.01e-10 Blood metabolite levels; CESC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg04414720 chr1:150670196 GOLPH3L 0.45 6.02 0.35 5.91e-9 Melanoma; CESC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg07414643 chr4:187882934 NA 0.54 7.9 0.44 7.51e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.53 8.0 0.44 3.86e-14 Bipolar disorder; CESC cis rs6938 0.618 rs12912839 chr15:75221245 C/T cg09165964 chr15:75287851 SCAMP5 0.47 6.32 0.36 1.12e-9 Breast cancer; CESC cis rs3617 0.573 rs56383738 chr3:52908398 T/C cg11645453 chr3:52864694 ITIH4 -0.27 -5.31 -0.31 2.33e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs4835473 0.831 rs7689322 chr4:144894914 A/G cg25736465 chr4:144833511 NA 0.39 5.97 0.34 7.43e-9 Immature fraction of reticulocytes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04141250 chr12:120729794 NA 0.46 6.2 0.36 2.12e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.81 10.7 0.55 1.86e-22 Alzheimer's disease; CESC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg16680214 chr1:154839983 KCNN3 -0.44 -6.76 -0.38 8.73e-11 Prostate cancer; CESC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg00080972 chr5:178986291 RUFY1 0.48 7.76 0.43 1.86e-13 Lung cancer; CESC cis rs1348850 0.526 rs4243389 chr2:178379783 G/C cg22681709 chr2:178499509 PDE11A -0.5 -5.26 -0.31 2.97e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg13877915 chr19:58951672 ZNF132 0.39 5.81 0.34 1.83e-8 Uric acid clearance; CESC cis rs6582630 0.593 rs7299329 chr12:38447943 G/C cg26384229 chr12:38710491 ALG10B 0.69 10.55 0.54 5.83e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg21724239 chr8:58056113 NA 0.56 5.96 0.34 8.22e-9 Developmental language disorder (linguistic errors); CESC cis rs9640161 0.789 rs34495356 chr7:150057791 A/G cg21361702 chr7:150065534 REPIN1 0.6 6.57 0.37 2.63e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs701145 0.529 rs355746 chr3:153961627 C/G cg16511985 chr3:153974050 SGEF 0.46 6.25 0.36 1.66e-9 Coronary artery disease; CESC cis rs7259376 0.846 rs4024624 chr19:22568264 C/T cg02657401 chr19:22469223 NA -0.25 -5.1 -0.3 6.58e-7 Menopause (age at onset); CESC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg07167872 chr1:205819463 PM20D1 0.43 6.62 0.38 1.98e-10 Menarche (age at onset); CESC cis rs796364 0.806 rs10931890 chr2:201102055 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.76 -6.61 -0.38 2.14e-10 Schizophrenia; CESC cis rs116095464 1.000 rs56075848 chr5:308352 T/C cg10591111 chr5:226296 SDHA -0.63 -5.72 -0.33 2.8e-8 Breast cancer; CESC trans rs9467711 0.606 rs72841536 chr6:26378288 T/A cg06606381 chr12:133084897 FBRSL1 -0.73 -6.26 -0.36 1.53e-9 Autism spectrum disorder or schizophrenia; CESC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg21963583 chr11:68658836 MRPL21 -0.36 -5.18 -0.3 4.48e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6598955 0.671 rs7550997 chr1:26596080 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.36 5.09 0.3 6.7e-7 Obesity-related traits; CESC cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg23711669 chr6:146136114 FBXO30 0.95 12.49 0.61 1.83e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.55 7.27 0.41 4.05e-12 Lymphocyte counts; CESC cis rs9473147 0.543 rs9296558 chr6:47451883 C/T cg20196966 chr6:47445060 CD2AP 0.41 5.35 0.31 1.91e-7 Platelet distribution width;Mean platelet volume; CESC cis rs8180040 0.932 rs62248599 chr3:47516728 G/A cg27129171 chr3:47204927 SETD2 -0.63 -9.49 -0.5 1.44e-18 Colorectal cancer; CESC trans rs9951602 0.512 rs6506868 chr18:76642559 C/G cg02800362 chr5:177631904 HNRNPAB 0.62 8.1 0.45 1.96e-14 Obesity-related traits; CESC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg21548813 chr6:291882 DUSP22 -0.76 -10.45 -0.54 1.28e-21 Menopause (age at onset); CESC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg09359103 chr1:154839909 KCNN3 -0.67 -12.45 -0.61 2.6e-28 Prostate cancer; CESC cis rs7587476 0.822 rs6726763 chr2:215681580 T/G cg04004882 chr2:215674386 BARD1 0.53 5.89 0.34 1.16e-8 Neuroblastoma; CESC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg16145915 chr7:1198662 ZFAND2A -0.52 -7.97 -0.44 4.59e-14 Longevity;Endometriosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24877558 chr1:42801138 FOXJ3 -0.46 -6.05 -0.35 4.98e-9 Fibrinogen levels; CESC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg11987759 chr7:65425863 GUSB 0.45 6.06 0.35 4.53e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17966709 chr11:57435952 ZDHHC5 0.59 6.86 0.39 4.94e-11 Gut microbiome composition (summer); CESC cis rs9858542 1.000 rs34762726 chr3:49689210 G/A cg07274523 chr3:49395745 GPX1 0.67 8.54 0.46 1.03e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs17209837 0.607 rs4148810 chr7:87102251 C/T cg00919237 chr7:87102261 ABCB4 -0.51 -6.51 -0.37 3.66e-10 Gallbladder cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02331450 chr3:33155354 CRTAP -0.42 -6.06 -0.35 4.72e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4076764 0.914 rs12123378 chr1:163377846 C/T cg06092702 chr1:163392909 NA -0.42 -6.15 -0.35 2.8e-9 Motion sickness; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22118131 chr15:78369834 TBC1D2B -0.44 -6.48 -0.37 4.52e-10 Gambling; CESC cis rs17428076 0.514 rs3821095 chr2:172684006 A/G cg13550731 chr2:172543902 DYNC1I2 -0.56 -7.75 -0.43 1.99e-13 Myopia; CESC cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4975616 0.686 rs37011 chr5:1348798 A/T cg26373071 chr5:1325741 CLPTM1L 0.45 7.29 0.41 3.58e-12 Lung cancer; CESC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.82 0.48 1.53e-16 Bipolar disorder; CESC cis rs11690935 0.571 rs1008151 chr2:172912098 G/A cg13550731 chr2:172543902 DYNC1I2 0.48 6.36 0.36 8.59e-10 Schizophrenia; CESC trans rs7824557 0.583 rs2263512 chr8:11233419 T/G cg06636001 chr8:8085503 FLJ10661 -0.5 -6.31 -0.36 1.14e-9 Retinal vascular caliber; CESC cis rs854765 0.693 rs4924823 chr17:17764502 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.6 -8.85 -0.48 1.24e-16 Total body bone mineral density; CESC cis rs34779708 0.931 rs12240347 chr10:35359475 A/G cg03585969 chr10:35415529 CREM 0.76 9.94 0.52 5.37e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs2742234 0.578 rs2742241 chr10:43625223 G/A cg07801480 chr10:43725741 RASGEF1A 0.41 5.3 0.31 2.44e-7 Hirschsprung disease; CESC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg26939375 chr7:64535504 NA -0.75 -10.83 -0.55 7.3e-23 Aortic root size; CESC trans rs7246760 1.000 rs10418248 chr19:9938214 T/A cg02900749 chr2:68251473 NA -0.74 -6.81 -0.39 6.57e-11 Pursuit maintenance gain; CESC cis rs9486715 0.830 rs2475023 chr6:96996833 G/A cg06623918 chr6:96969491 KIAA0776 -0.95 -15.19 -0.68 6.54e-38 Headache; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27022678 chr5:140563942 PCDHB16 -0.57 -7.09 -0.4 1.25e-11 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19244826 chr22:19466934 UFD1L;CDC45L -0.45 -6.15 -0.35 2.77e-9 Asthma; CESC cis rs12477438 0.798 rs896886 chr2:99652713 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.72 10.53 0.54 6.66e-22 Chronic sinus infection; CESC cis rs2243480 1.000 rs2243480 chr7:65599196 C/T cg18252515 chr7:66147081 NA -1.18 -11.21 -0.57 3.97e-24 Diabetic kidney disease; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg04903157 chr22:35795952 MCM5 0.49 6.1 0.35 3.69e-9 Thyroid stimulating hormone; CESC cis rs2243480 1.000 rs1267820 chr7:66050295 C/G cg18252515 chr7:66147081 NA -1.4 -14.23 -0.66 1.55e-34 Diabetic kidney disease; CESC cis rs9308433 0.529 rs4655336 chr1:214499667 A/C cg06198575 chr1:214491504 SMYD2 0.49 5.98 0.34 7.22e-9 IgG glycosylation; CESC trans rs1557351 0.723 rs1942344 chr18:54720778 A/G cg11433624 chr6:7146702 RREB1 0.39 6.27 0.36 1.48e-9 Multiple sclerosis (age of onset); CESC cis rs113835537 0.866 rs59320108 chr11:66365996 A/T cg24851651 chr11:66362959 CCS 0.61 5.46 0.32 1.11e-7 Airway imaging phenotypes; CESC cis rs4132509 1.000 rs2291410 chr1:243716654 A/C cg21452805 chr1:244014465 NA -0.43 -5.31 -0.31 2.36e-7 RR interval (heart rate); CESC cis rs9916302 0.904 rs4357971 chr17:37717280 C/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs2576037 0.796 rs2571018 chr18:44585344 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.61 -8.76 -0.47 2.43e-16 Personality dimensions; CESC cis rs698813 0.604 rs7565928 chr2:44489956 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.51 0.32 8.66e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2354432 0.556 rs11239964 chr1:146753902 G/C cg25205988 chr1:146714368 CHD1L -0.92 -7.89 -0.44 7.91e-14 Mitochondrial DNA levels; CESC cis rs11098499 0.863 rs59732491 chr4:120489588 G/C cg09307838 chr4:120376055 NA 0.91 12.59 0.61 8.49e-29 Corneal astigmatism; CESC cis rs11608355 0.515 rs7971160 chr12:109946751 T/A cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs7714584 0.793 rs7709721 chr5:150246858 A/G cg22134413 chr5:150180641 NA 0.5 5.76 0.33 2.3e-8 Crohn's disease; CESC cis rs698833 0.886 rs2289463 chr2:44565447 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.53 6.74 0.38 9.88e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg20151795 chr6:28129481 ZNF389 -0.4 -5.49 -0.32 9.54e-8 Depression; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02656959 chr1:21786446 NBPF3 0.46 6.28 0.36 1.39e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs634534 0.622 rs624273 chr11:65712413 A/G cg17712092 chr4:129076599 LARP1B 0.55 6.8 0.39 7.08e-11 Sum eosinophil basophil counts;Eosinophil counts; CESC trans rs61931739 0.817 rs1705771 chr12:34174950 C/G cg26384229 chr12:38710491 ALG10B 0.48 6.57 0.37 2.6200000000000003e-10 Morning vs. evening chronotype; CESC cis rs4889855 0.614 rs9898443 chr17:78469357 C/T cg16591659 chr17:78472290 NA 0.52 7.92 0.44 6.49e-14 Fractional excretion of uric acid; CESC cis rs6828523 0.698 rs80082041 chr4:175855409 A/G cg14561282 chr4:175839468 ADAM29 0.44 5.15 0.3 5.09e-7 Breast cancer; CESC cis rs6942756 1.000 rs6467235 chr7:128939150 A/G cg02491457 chr7:128862824 NA 0.74 8.22 0.45 9.29e-15 White matter hyperintensity burden; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05654483 chr10:122610929 WDR11 0.52 6.12 0.35 3.36e-9 Gut microbiome composition (summer); CESC cis rs13394619 0.655 rs7578132 chr2:11718858 C/T cg07314298 chr2:11723111 GREB1 -0.46 -6.32 -0.36 1.09e-9 Endometriosis; CESC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg14926445 chr8:58193284 C8orf71 -0.54 -5.21 -0.31 3.73e-7 Developmental language disorder (linguistic errors); CESC cis rs15676 0.947 rs2997913 chr9:131589033 C/T cg00228799 chr9:131580591 ENDOG 0.44 5.54 0.32 7.2e-8 Blood metabolite levels; CESC cis rs7312933 0.558 rs4768399 chr12:42742696 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.43 -0.37 5.79e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21271961 chr1:95285780 SLC44A3 -0.44 -6.37 -0.36 8.51e-10 Gambling; CESC cis rs72781680 1.000 rs55773155 chr2:24255081 A/G cg20701182 chr2:24300061 SF3B14 0.97 8.24 0.45 7.96e-15 Lymphocyte counts; CESC cis rs6540556 0.769 rs10157973 chr1:209924425 C/T cg23920097 chr1:209922102 NA -0.38 -5.31 -0.31 2.27e-7 Red blood cell count; CESC cis rs73206853 0.841 rs56017652 chr12:110931054 C/T cg12870014 chr12:110450643 ANKRD13A 0.63 5.22 0.31 3.56e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 6.17 0.35 2.56e-9 Bipolar disorder; CESC cis rs1559088 0.948 rs10408093 chr19:33597816 T/C cg17764715 chr19:33622953 WDR88 0.48 6.31 0.36 1.17e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs11122272 0.735 rs2244986 chr1:231537452 C/T cg06096015 chr1:231504339 EGLN1 0.42 6.13 0.35 3.17e-9 Hemoglobin concentration; CESC cis rs8077577 0.895 rs62073615 chr17:18080329 T/A cg16794390 chr17:18148240 FLII 0.46 5.78 0.33 2.13e-8 Obesity-related traits; CESC cis rs920590 0.758 rs1817836 chr8:19664852 T/C cg17834443 chr8:19674713 INTS10 0.58 6.75 0.38 9.22e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs10751667 0.666 rs10902241 chr11:949129 G/A cg06064525 chr11:970664 AP2A2 -0.48 -9.45 -0.5 1.86e-18 Alzheimer's disease (late onset); CESC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg23758822 chr17:41437982 NA 0.99 16.59 0.71 6.91e-43 Menopause (age at onset); CESC cis rs317689 0.513 rs317678 chr12:69692166 C/G cg14784868 chr12:69753453 YEATS4 0.52 6.49 0.37 4.29e-10 Response to diuretic therapy; CESC cis rs35110281 0.659 rs73367822 chr21:45024252 C/T cg21573476 chr21:45109991 RRP1B -0.47 -6.55 -0.37 3.01e-10 Mean corpuscular volume; CESC cis rs826838 1.000 rs10506122 chr12:38699232 A/G cg13010199 chr12:38710504 ALG10B 0.62 8.96 0.48 6.04e-17 Heart rate; CESC trans rs61931739 0.500 rs11053236 chr12:34507962 C/G cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.31e-22 Morning vs. evening chronotype; CESC cis rs2075671 0.903 rs62482252 chr7:100274063 C/A cg16850897 chr7:100343110 ZAN -0.69 -8.36 -0.46 3.62e-15 Other erythrocyte phenotypes; CESC trans rs801193 1.000 rs4279493 chr7:66226620 C/T cg26939375 chr7:64535504 NA 0.67 9.16 0.49 1.49e-17 Aortic root size; CESC cis rs796364 0.616 rs7589545 chr2:200676102 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.54 5.09 0.3 6.86e-7 Schizophrenia; CESC cis rs2228479 0.850 rs11641552 chr16:89838700 C/A cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs2742234 0.541 rs11238479 chr10:43717423 C/T cg07801480 chr10:43725741 RASGEF1A -0.4 -5.24 -0.31 3.22e-7 Hirschsprung disease; CESC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg22535103 chr8:58192502 C8orf71 -1.07 -13.22 -0.63 5.72e-31 Developmental language disorder (linguistic errors); CESC cis rs5758659 0.652 rs133347 chr22:42423645 A/T cg19513890 chr22:42538836 CYP2D7P1 -0.39 -5.82 -0.34 1.69e-8 Cognitive function; CESC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg00129232 chr17:37814104 STARD3 -0.6 -7.99 -0.44 4.15e-14 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00888876 chr4:74124772 ANKRD17 0.6 6.74 0.38 9.62e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02708898 chr8:54755848 ATP6V1H 0.57 6.14 0.35 3e-9 Gut microbiome composition (summer); CESC cis rs6456156 0.792 rs9366089 chr6:167512896 A/G cg07741184 chr6:167504864 NA 0.37 6.61 0.38 2.1e-10 Primary biliary cholangitis; CESC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs3733585 0.673 rs7375587 chr4:9954758 A/T cg02734326 chr4:10020555 SLC2A9 0.41 5.92 0.34 9.96e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7639513 0.545 rs13061104 chr3:12717321 G/T cg23032965 chr3:12705835 RAF1 0.68 7.42 0.41 1.58e-12 Itch intensity from mosquito bite; CESC cis rs6582630 0.502 rs4309219 chr12:38293584 A/G cg13010199 chr12:38710504 ALG10B 0.4 5.14 0.3 5.25e-7 Drug-induced liver injury (flucloxacillin); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08330117 chr8:90770456 RIPK2 0.48 6.44 0.37 5.5e-10 Gut microbiota (bacterial taxa); CESC cis rs79839061 0.732 rs11734742 chr4:821565 C/T cg07828340 chr4:882639 GAK 0.83 6.03 0.35 5.37e-9 Intelligence (multi-trait analysis); CESC cis rs662064 0.962 rs596537 chr1:10554709 G/T cg20482658 chr1:10539492 PEX14 -0.36 -7.27 -0.41 4.01e-12 Asthma; CESC trans rs10506458 0.915 rs12423078 chr12:63397529 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.34 -18.94 -0.76 3.59e-51 Hemostatic factors and hematological phenotypes; CESC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs9911578 1.000 rs8079774 chr17:56908188 A/G cg12560992 chr17:57184187 TRIM37 0.94 15.75 0.7 6.57e-40 Intelligence (multi-trait analysis); CESC cis rs10751667 0.643 rs11246348 chr11:939476 G/C cg20946044 chr11:1010712 AP2A2 -0.41 -5.64 -0.33 4.31e-8 Alzheimer's disease (late onset); CESC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.15 0.4 8.48e-12 Height; CESC cis rs9596863 1.000 rs9568941 chr13:54419426 A/G ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs2204008 0.774 rs2387811 chr12:38369794 C/A cg26384229 chr12:38710491 ALG10B 0.74 10.65 0.55 2.8e-22 Bladder cancer; CESC cis rs66573146 0.572 rs67922134 chr4:6955772 G/A cg26116260 chr4:7069785 GRPEL1 -0.79 -5.16 -0.3 4.78e-7 Granulocyte percentage of myeloid white cells; CESC cis rs4808199 0.843 rs10402308 chr19:19657500 G/A cg03709012 chr19:19516395 GATAD2A 1.04 12.91 0.62 6.34e-30 Nonalcoholic fatty liver disease; CESC cis rs854765 0.647 rs2974998 chr17:17995619 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 5.9 0.34 1.1e-8 Total body bone mineral density; CESC cis rs13102973 0.965 rs7656631 chr4:135869921 C/T cg14419869 chr4:135874104 NA -0.4 -6.29 -0.36 1.32e-9 Subjective well-being; CESC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg14780466 chr2:20870812 GDF7 -0.47 -7.77 -0.43 1.73e-13 Abdominal aortic aneurysm; CESC cis rs965469 1.000 rs6037554 chr20:3315613 G/A cg25506879 chr20:3388711 C20orf194 -0.53 -5.81 -0.34 1.78e-8 IFN-related cytopenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04109349 chr1:245317172 KIF26B -0.41 -6.14 -0.35 3.07e-9 Gambling; CESC cis rs660498 0.526 rs610451 chr10:27705152 A/G cg11203244 chr10:27609286 NA -0.36 -5.17 -0.3 4.58e-7 Asthma (childhood onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04237075 chr9:34637949 SIGMAR1 0.48 6.11 0.35 3.58e-9 Gut microbiota (bacterial taxa); CESC cis rs4834770 1.000 rs1397613 chr4:120242929 G/T cg09307838 chr4:120376055 NA 0.45 5.37 0.31 1.74e-7 Blood protein levels; CESC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs1707322 0.686 rs2991977 chr1:46053683 G/A cg03146154 chr1:46216737 IPP -0.75 -10.01 -0.52 3.19e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7914558 0.966 rs10883817 chr10:104755431 C/T cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.51e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg10691866 chr7:65817282 TPST1 0.31 5.26 0.31 2.97e-7 Aortic root size; CESC cis rs1707322 0.827 rs6683274 chr1:46241638 T/G cg05343316 chr1:45956843 TESK2 0.5 5.98 0.34 7.2e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg11764359 chr7:65958608 NA -0.91 -14.71 -0.67 3.26e-36 Aortic root size; CESC cis rs7208859 0.623 rs3752019 chr17:29151705 C/T cg19761014 chr17:28927070 LRRC37B2 0.74 6.03 0.35 5.43e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7843479 0.601 rs12056476 chr8:21854188 T/A cg17168535 chr8:21777572 XPO7 0.71 11.2 0.57 4.39e-24 Mean corpuscular volume; CESC cis rs7577696 0.711 rs385076 chr2:32489851 T/C cg02381751 chr2:32503542 YIPF4 0.42 5.27 0.31 2.85e-7 Inflammatory biomarkers; CESC cis rs10861342 1.000 rs10861360 chr12:105570041 A/G cg23923672 chr12:105501055 KIAA1033 -0.8 -7.21 -0.4 5.91e-12 IgG glycosylation; CESC cis rs11122272 0.701 rs2790894 chr1:231505587 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.15 -0.4 8.55e-12 Hemoglobin concentration; CESC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg20891558 chr2:74357851 NA 0.87 12.53 0.61 1.39e-28 Gestational age at birth (maternal effect); CESC cis rs2635047 0.682 rs4534948 chr18:44793419 G/A cg24371990 chr18:44770781 NA 0.39 6.26 0.36 1.5e-9 Educational attainment; CESC cis rs2985684 0.948 rs2985685 chr14:50101370 G/A cg02151108 chr14:50098012 C14orf104 -0.42 -5.48 -0.32 9.97e-8 Carotid intima media thickness; CESC cis rs9611565 0.765 rs132906 chr22:41799767 G/C cg06481639 chr22:41940642 POLR3H 0.45 5.36 0.31 1.85e-7 Vitiligo; CESC cis rs11785693 0.862 rs11782343 chr8:5001642 C/G cg26367366 chr8:4980734 NA 0.52 5.23 0.31 3.43e-7 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg17143192 chr8:8559678 CLDN23 0.77 9.05 0.49 3.19e-17 Obesity-related traits; CESC trans rs12063142 0.673 rs72651812 chr1:19141142 C/G cg08487374 chr7:100076562 TSC22D4 0.74 6.37 0.36 8.2e-10 Parkinson's disease; CESC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg00074818 chr8:8560427 CLDN23 0.36 5.24 0.31 3.32e-7 Obesity-related traits; CESC cis rs367615 0.704 rs4286723 chr5:108835959 G/A cg17395555 chr5:108820864 NA 0.62 11.06 0.56 1.27e-23 Colorectal cancer (SNP x SNP interaction); CESC trans rs7615952 0.641 rs60839048 chr3:125807938 G/A cg07211511 chr3:129823064 LOC729375 -0.56 -6.22 -0.36 1.92e-9 Blood pressure (smoking interaction); CESC cis rs72945132 0.882 rs3781648 chr11:70190058 T/C cg00319359 chr11:70116639 PPFIA1 0.72 6.84 0.39 5.42e-11 Coronary artery disease; CESC cis rs2880765 0.835 rs12910373 chr15:86046802 G/C cg19183879 chr15:85880815 NA -0.26 -5.29 -0.31 2.52e-7 Coronary artery disease; CESC cis rs9788682 0.747 rs2938674 chr15:78757913 C/A cg24631222 chr15:78858424 CHRNA5 0.62 7.24 0.41 4.83e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07959380 chr16:89894648 SPIRE2 -0.42 -6.0 -0.35 6.34e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8033133 1.000 rs8033133 chr15:25350474 A/G cg14481604 chr15:25334117 SNORD116-22 -0.37 -5.41 -0.32 1.42e-7 Blood osmolality (transformed sodium); CESC cis rs1707322 0.686 rs2991987 chr1:46081422 C/G cg06784218 chr1:46089804 CCDC17 -0.43 -7.52 -0.42 8.27e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4803455 0.565 rs1800470 chr19:41858921 G/A cg08477640 chr19:41863820 B9D2 0.5 6.94 0.39 3.03e-11 Migraine;Coronary artery disease; CESC cis rs7552404 0.961 rs211710 chr1:76109038 G/A cg10523679 chr1:76189770 ACADM -0.64 -7.13 -0.4 9.27e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2302190 0.882 rs7221205 chr17:56485799 G/A cg25885038 chr17:56607967 SEPT4 -0.4 -5.41 -0.32 1.42e-7 Vitamin D levels; CESC cis rs524281 0.861 rs10896095 chr11:65962560 A/G cg14036092 chr11:66035641 RAB1B -0.52 -5.7 -0.33 3.17e-8 Electroencephalogram traits; CESC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg03188948 chr7:1209495 NA 0.68 6.53 0.37 3.35e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11098499 0.955 rs11944880 chr4:120159334 A/G cg09307838 chr4:120376055 NA -0.86 -11.3 -0.57 2.01e-24 Corneal astigmatism; CESC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.61 0.33 5.12e-8 Bipolar disorder; CESC cis rs9916302 0.861 rs4795376 chr17:37669043 T/C cg15445000 chr17:37608096 MED1 0.4 6.56 0.37 2.85e-10 Glomerular filtration rate (creatinine); CESC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg22143856 chr6:28129313 ZNF389 0.44 5.84 0.34 1.49e-8 Depression; CESC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg26516362 chr5:178986906 RUFY1 0.48 7.75 0.43 1.93e-13 Lung cancer; CESC cis rs1707322 0.691 rs28495425 chr1:46187320 T/G cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15358743 chr18:56807035 SEC11C 0.45 6.19 0.36 2.33e-9 Systemic lupus erythematosus; CESC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg27057461 chr7:158136379 PTPRN2 -0.34 -5.3 -0.31 2.46e-7 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08125682 chr16:11038455 CLEC16A 0.62 7.3 0.41 3.37e-12 Gut microbiome composition (summer); CESC cis rs1577917 1.000 rs12205548 chr6:86759770 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.14 -0.35 3.04e-9 Response to antipsychotic treatment; CESC cis rs7020830 0.867 rs55845273 chr9:37362219 C/T cg14294708 chr9:37120828 ZCCHC7 1.11 19.1 0.76 9.61e-52 Schizophrenia; CESC cis rs950169 1.000 rs35648189 chr15:84740748 T/C cg17507749 chr15:85114479 UBE2QP1 0.64 7.1 0.4 1.17e-11 Schizophrenia; CESC trans rs35110281 0.744 rs162395 chr21:44945759 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.66 0.38 1.59e-10 Mean corpuscular volume; CESC cis rs11608355 0.545 rs35018715 chr12:109893134 T/C cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs10751667 0.961 rs6597951 chr11:991530 C/T cg06064525 chr11:970664 AP2A2 -0.41 -6.99 -0.39 2.22e-11 Alzheimer's disease (late onset); CESC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg18225595 chr11:63971243 STIP1 0.7 9.36 0.5 3.65e-18 Platelet count; CESC cis rs6163 0.588 rs11191392 chr10:104526951 C/A cg04362960 chr10:104952993 NT5C2 0.39 5.28 0.31 2.74e-7 Waist circumference;Hip circumference; CESC trans rs116095464 0.558 rs10055354 chr5:243794 G/A cg00938859 chr5:1591904 SDHAP3 0.64 6.98 0.39 2.36e-11 Breast cancer; CESC cis rs9894429 0.816 rs9747093 chr17:79584280 G/A cg21984481 chr17:79567631 NPLOC4 -0.46 -7.64 -0.42 3.95e-13 Eye color traits; CESC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs5753037 0.653 rs140129 chr22:30150549 C/T cg01021169 chr22:30184971 ASCC2 -0.44 -6.08 -0.35 4.19e-9 Type 1 diabetes; CESC cis rs2735413 0.918 rs12918409 chr16:78082681 G/A cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7223966 1.000 rs73337598 chr17:61732576 T/C cg11494091 chr17:61959527 GH2 0.39 5.53 0.32 7.67e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg19498844 chr21:46707878 POFUT2;LOC642852 -0.86 -12.8 -0.62 1.61e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2382817 0.580 rs6756265 chr2:219095554 G/A cg00012203 chr2:219082015 ARPC2 -0.74 -9.9 -0.52 7.06e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg22875332 chr1:76189707 ACADM 0.7 9.6 0.51 6.53e-19 Blood metabolite levels;Acylcarnitine levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12177922 chr1:154245232 HAX1 -0.43 -6.16 -0.35 2.72e-9 Ulcerative colitis; CESC cis rs10256972 0.528 rs7784607 chr7:1178694 A/G cg18765753 chr7:1198926 ZFAND2A -0.45 -6.53 -0.37 3.38e-10 Longevity;Endometriosis; CESC cis rs2652822 0.509 rs4774478 chr15:63434763 A/G cg02713581 chr15:63449717 RPS27L 0.46 5.43 0.32 1.27e-7 Metabolic traits; CESC cis rs11864453 0.647 rs2550035 chr16:72113416 C/G cg01557791 chr16:72042693 DHODH -0.45 -5.96 -0.34 8.06e-9 Fibrinogen levels; CESC cis rs7107174 0.892 rs11237450 chr11:78023356 C/A cg02023728 chr11:77925099 USP35 0.47 6.16 0.35 2.7e-9 Testicular germ cell tumor; CESC cis rs10870270 0.913 rs4550 chr10:133781798 C/T cg08754478 chr10:133766260 PPP2R2D -0.59 -7.6 -0.42 5.25e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg17376030 chr22:41985996 PMM1 0.67 7.28 0.41 3.82e-12 Vitiligo; CESC cis rs7666738 0.546 rs10026181 chr4:98814118 C/T cg05340658 chr4:99064831 C4orf37 -0.55 -6.56 -0.37 2.87e-10 Colonoscopy-negative controls vs population controls; CESC cis rs1178968 0.901 rs1178958 chr7:72777384 G/A cg25889504 chr7:72793014 NA 0.51 5.42 0.32 1.36e-7 Triglyceride levels; CESC cis rs73206853 0.698 rs871922 chr12:111114942 T/C cg12870014 chr12:110450643 ANKRD13A 0.66 5.48 0.32 9.67e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs5769707 0.837 rs5770599 chr22:50019981 C/G cg20744362 chr22:50050164 C22orf34 0.44 7.22 0.41 5.51e-12 Monocyte count;Monocyte percentage of white cells; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg01249180 chr5:95997867 CAST -0.45 -6.04 -0.35 5.2e-9 Recombination measurement; CESC cis rs3741151 0.773 rs73542938 chr11:73103012 G/C cg17517138 chr11:73019481 ARHGEF17 0.98 7.14 0.4 8.86e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7666738 0.657 rs13102002 chr4:98617794 T/C cg17366294 chr4:99064904 C4orf37 0.51 5.29 0.31 2.53e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10411161 0.657 rs67462252 chr19:52382851 T/C cg22319618 chr22:45562946 NUP50 -0.69 -6.52 -0.37 3.48e-10 Breast cancer; CESC cis rs36051895 0.659 rs67006981 chr9:5070401 A/G cg02405213 chr9:5042618 JAK2 -0.51 -6.24 -0.36 1.72e-9 Pediatric autoimmune diseases; CESC cis rs10242455 0.867 rs2687139 chr7:99323074 A/C cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07869135 chr8:123794843 ZHX2 0.49 6.26 0.36 1.58e-9 Gut microbiota (bacterial taxa); CESC cis rs79387448 0.655 rs79144324 chr2:102932814 G/A cg09003973 chr2:102972529 NA 1.04 8.15 0.45 1.46e-14 Gut microbiota (bacterial taxa); CESC cis rs965513 1.000 rs7027030 chr9:100550455 A/C cg13688889 chr9:100608707 NA -0.6 -8.46 -0.46 1.88e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs12824058 0.831 rs4759653 chr12:130812604 T/C cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs11122272 0.735 rs2749714 chr1:231538634 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.47 -0.42 1.14e-12 Hemoglobin concentration; CESC cis rs8017423 0.904 rs4603489 chr14:90760607 A/G cg14092571 chr14:90743983 NA 0.55 8.28 0.45 6.32e-15 Mortality in heart failure; CESC trans rs116095464 0.510 rs55750776 chr5:230467 T/C cg00938859 chr5:1591904 SDHAP3 0.61 6.74 0.38 9.82e-11 Breast cancer; CESC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg10150615 chr22:24372951 LOC391322 0.58 6.71 0.38 1.16e-10 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs238295 0.881 rs6116869 chr20:5594432 G/T cg24001556 chr20:5591874 RP5-1022P6.2 0.53 5.91 0.34 1.04e-8 Occipital cortical area (total cortical area interaction); CESC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg05861140 chr6:150128134 PCMT1 -0.35 -5.07 -0.3 7.45e-7 Lung cancer; CESC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.68 -0.51 3.46e-19 Alzheimer's disease; CESC cis rs1707322 0.655 rs3014240 chr1:46089225 C/G cg05343316 chr1:45956843 TESK2 -0.52 -6.53 -0.37 3.41e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3857067 0.806 rs1876918 chr4:95099424 G/A cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.01 -0.48 4.22e-17 QT interval; CESC cis rs17253792 0.915 rs28663681 chr14:56178820 A/T cg24579896 chr14:56047964 C14orf33;KTN1 0.74 5.1 0.3 6.53e-7 Putamen volume; CESC cis rs425277 0.958 rs262660 chr1:2086757 A/G cg04315214 chr1:2043799 PRKCZ -0.38 -5.31 -0.31 2.35e-7 Height; CESC cis rs9443645 0.901 rs7742431 chr6:79679577 A/G cg05283184 chr6:79620031 NA -0.41 -6.42 -0.37 6.26e-10 Intelligence (multi-trait analysis); CESC cis rs4911259 0.593 rs6058924 chr20:31464467 G/A cg13636640 chr20:31349939 DNMT3B -0.54 -7.47 -0.42 1.16e-12 Inflammatory bowel disease; CESC cis rs6484504 0.576 rs16922084 chr11:31371109 C/T cg14844989 chr11:31128820 NA 0.39 5.25 0.31 3.13e-7 Red blood cell count; CESC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg03188948 chr7:1209495 NA 0.73 7.85 0.43 1.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2274273 0.806 rs7146752 chr14:55738907 A/G cg04306507 chr14:55594613 LGALS3 0.29 5.65 0.33 4.17e-8 Protein biomarker; CESC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg18758796 chr5:131593413 PDLIM4 0.42 5.61 0.33 5.09e-8 Acylcarnitine levels; CESC cis rs72820985 0.504 rs8055721 chr16:80803117 G/T cg05451730 chr16:80358022 NA 0.42 5.09 0.3 6.65e-7 Breast cancer; CESC cis rs4555082 0.834 rs2735822 chr14:105712734 C/T cg27165867 chr14:105738592 BRF1 -0.51 -5.42 -0.32 1.31e-7 Mean platelet volume;Platelet distribution width; CESC cis rs1620921 0.756 rs783163 chr6:161182401 A/T cg01280913 chr6:161186852 NA -0.43 -6.41 -0.37 6.63e-10 Lipoprotein (a) - cholesterol levels; CESC trans rs1223629 1.000 rs11187805 chr10:95944685 T/A cg16346422 chr11:2920819 SLC22A18;SLC22A18AS 0.67 6.05 0.35 4.83e-9 Glucose homeostasis traits; CESC cis rs9300255 0.699 rs11057204 chr12:123725827 T/C cg19016782 chr12:123741754 C12orf65 -0.48 -6.72 -0.38 1.12e-10 Neutrophil percentage of white cells; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08949862 chr2:63277672 OTX1 0.49 6.31 0.36 1.16e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg26939375 chr7:64535504 NA 0.63 8.55 0.47 9.86e-16 Calcium levels; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg04067598 chr5:70751409 BDP1 0.44 6.18 0.35 2.47e-9 Attention deficit hyperactivity disorder; CESC trans rs79976124 0.877 rs79507557 chr6:66640908 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 8.24 0.45 7.76e-15 Type 2 diabetes; CESC cis rs11577318 0.853 rs4471263 chr1:26622700 C/T cg00852783 chr1:26633632 UBXN11 0.52 7.09 0.4 1.23e-11 Granulocyte percentage of myeloid white cells; CESC cis rs7130144 0.541 rs7949893 chr11:130462408 G/A cg26307797 chr11:130446613 NA -0.76 -6.78 -0.38 7.92e-11 Urate levels in lean individuals; CESC cis rs2477686 0.526 rs12042427 chr1:2398107 C/T cg11214544 chr1:2391121 NA -0.46 -7.07 -0.4 1.35e-11 Non-obstructive azoospermia; CESC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg27125505 chr17:43679177 LOC644172 -0.48 -6.62 -0.38 2.01e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg08499158 chr17:42289980 UBTF -0.56 -7.2 -0.4 6.2e-12 Total body bone mineral density; CESC cis rs793571 0.744 rs11630265 chr15:59159826 C/T cg05156742 chr15:59063176 FAM63B -0.47 -6.15 -0.35 2.78e-9 Schizophrenia; CESC cis rs6665290 0.935 rs12409755 chr1:227196949 A/T cg10327440 chr1:227177885 CDC42BPA -1.23 -33.54 -0.9 2.34e-97 Myeloid white cell count; CESC cis rs3015497 0.561 rs3015469 chr14:51157160 C/T cg26011998 chr14:51135199 SAV1 -0.54 -6.17 -0.35 2.55e-9 Mean platelet volume; CESC cis rs722599 0.683 rs8011071 chr14:75286705 T/C cg08847533 chr14:75593920 NEK9 0.48 6.0 0.35 6.61e-9 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03638180 chr17:65373763 PITPNC1 0.61 6.64 0.38 1.76e-10 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs12452509 chr17:37574722 G/A cg00129232 chr17:37814104 STARD3 -0.56 -7.35 -0.41 2.4e-12 Glomerular filtration rate (creatinine); CESC trans rs7726839 0.574 rs12522955 chr5:639231 C/A cg25482853 chr8:67687455 SGK3 1.01 10.03 0.52 2.8e-20 Obesity-related traits; CESC cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg05425664 chr17:57184151 TRIM37 0.51 7.09 0.4 1.2e-11 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06111305 chr13:98086784 RAP2A -0.55 -6.14 -0.35 3.02e-9 Gut microbiome composition (summer); CESC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs9486719 1.000 rs2499807 chr6:96864053 T/G cg06623918 chr6:96969491 KIAA0776 0.82 8.4 0.46 2.72e-15 Migraine;Coronary artery disease; CESC cis rs2404602 0.552 rs11072613 chr15:76961526 A/C cg00316803 chr15:76480434 C15orf27 0.38 5.08 0.3 7.29e-7 Blood metabolite levels; CESC cis rs7615952 0.551 rs12695470 chr3:125635718 C/A cg05084668 chr3:125655381 ALG1L -0.49 -5.52 -0.32 8e-8 Blood pressure (smoking interaction); CESC cis rs7084402 1.000 rs7910442 chr10:60270260 T/G cg07615347 chr10:60278583 BICC1 -0.57 -8.71 -0.47 3.43e-16 Refractive error; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01571169 chr16:87367721 FBXO31 0.52 6.82 0.39 6.1e-11 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05007375 chr14:92588364 NDUFB1;CPSF2 0.59 7.17 0.4 7.64e-12 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.74 0.55 1.39e-22 Height; CESC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs9911578 0.900 rs4793593 chr17:56892699 C/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.37 -5.04 -0.3 8.47e-7 Intelligence (multi-trait analysis); CESC cis rs7208859 0.573 rs60724269 chr17:29113273 G/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6121246 0.559 rs10439608 chr20:30258814 T/C cg13852791 chr20:30311386 BCL2L1 0.81 10.53 0.54 6.68e-22 Mean corpuscular hemoglobin; CESC cis rs7843479 0.601 rs10866837 chr8:21861663 G/C cg17168535 chr8:21777572 XPO7 0.7 10.73 0.55 1.59e-22 Mean corpuscular volume; CESC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg22535103 chr8:58192502 C8orf71 -0.94 -9.35 -0.5 3.78e-18 Developmental language disorder (linguistic errors); CESC cis rs193541 0.555 rs2438151 chr5:122199197 A/G cg19412675 chr5:122181750 SNX24 0.48 5.69 0.33 3.28e-8 Glucose homeostasis traits; CESC cis rs1865721 1.000 rs1865721 chr18:73192446 C/T cg26385618 chr18:73139727 C18orf62 -0.51 -7.5 -0.42 9.85e-13 Intelligence; CESC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.75 7.05 0.4 1.55e-11 Depression; CESC cis rs3936840 0.964 rs10150698 chr14:102977876 A/G cg18135206 chr14:102964638 TECPR2 0.48 6.49 0.37 4.12e-10 Plateletcrit; CESC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg23048001 chr7:2026167 MAD1L1 -0.48 -6.27 -0.36 1.45e-9 Bipolar disorder and schizophrenia; CESC cis rs4253772 0.530 rs55653327 chr22:46682976 C/T cg00784671 chr22:46762841 CELSR1 -0.62 -6.02 -0.35 5.64e-9 LDL cholesterol;Cholesterol, total; CESC cis rs72781680 1.000 rs6751655 chr2:24155478 A/G cg08917208 chr2:24149416 ATAD2B 1.04 9.49 0.5 1.4e-18 Lymphocyte counts; CESC cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg24308560 chr3:49941425 MST1R -0.63 -9.02 -0.48 3.81e-17 Intelligence (multi-trait analysis); CESC cis rs9796 0.775 rs57393155 chr15:41426251 A/G cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.27 -0.36 1.5e-9 Menopause (age at onset); CESC cis rs4654899 0.812 rs7539512 chr1:21410791 A/G cg05370193 chr1:21551575 ECE1 0.37 5.57 0.32 6.34e-8 Superior frontal gyrus grey matter volume; CESC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg07308232 chr7:1071921 C7orf50 -0.54 -7.34 -0.41 2.67e-12 Longevity;Endometriosis; CESC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg10596483 chr8:143751796 JRK -0.42 -5.06 -0.3 7.93e-7 Urinary tract infection frequency; CESC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.59 7.71 0.43 2.62e-13 Menopause (age at onset); CESC cis rs6736093 0.966 rs34087685 chr2:112693010 G/C cg12686935 chr2:112915763 FBLN7 -0.44 -5.72 -0.33 2.86e-8 Coronary artery disease; CESC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs698833 0.508 rs698765 chr2:44573671 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.66 0.33 3.83e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs11122272 0.668 rs2808616 chr1:231554993 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.51 6.9 0.39 3.81e-11 Hemoglobin concentration; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg03274021 chr8:130952480 FAM49B 0.62 6.08 0.35 4.13e-9 Diastolic blood pressure; CESC cis rs1707322 0.663 rs3935296 chr1:46180470 T/C cg05343316 chr1:45956843 TESK2 -0.51 -6.2 -0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9788682 1.000 rs7181447 chr15:78814567 A/G cg24631222 chr15:78858424 CHRNA5 0.73 9.27 0.49 6.82e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs34421088 0.678 rs35928010 chr8:11591876 C/T cg12395012 chr8:11607386 GATA4 0.4 5.9 0.34 1.1e-8 Neuroticism; CESC trans rs9850225 0.719 rs4856616 chr3:80466481 A/C cg24448245 chr7:66461718 SBDS;TYW1 0.42 6.0 0.35 6.39e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs2929278 0.588 rs688009 chr15:44156302 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.46 7.2 0.4 6.29e-12 Schizophrenia; CESC cis rs12136530 0.651 rs12141760 chr1:19717901 C/T cg01832549 chr1:19774989 CAPZB -0.41 -5.75 -0.33 2.41e-8 Lead levels in blood; CESC trans rs9833726 0.799 rs35614120 chr3:86138618 T/C cg10416071 chr15:75628863 COMMD4 0.59 6.12 0.35 3.37e-9 Breast cancer; CESC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg06873352 chr17:61820015 STRADA 0.71 12.47 0.61 2.23e-28 Prudent dietary pattern; CESC cis rs4950322 0.748 rs56392137 chr1:146824196 A/G cg22381352 chr1:146742008 CHD1L -0.49 -5.27 -0.31 2.89e-7 Protein quantitative trait loci; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg03252340 chr4:83293766 HNRNPD 0.47 6.35 0.36 9.56e-10 Recombination measurement; CESC trans rs9937837 1.000 rs34594027 chr16:31318314 T/C cg04903759 chr3:167238645 WDR49 0.52 6.5 0.37 3.93e-10 Systemic lupus erythematosus; CESC cis rs3806843 0.966 rs2563263 chr5:140137644 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.43 -5.56 -0.32 6.51e-8 Depressive symptoms (multi-trait analysis); CESC cis rs8092503 1.000 rs7236320 chr18:52475051 C/T cg12377874 chr18:52495404 RAB27B 0.37 5.97 0.34 7.65e-9 Childhood body mass index; CESC cis rs11098499 0.954 rs10006706 chr4:120409152 A/G cg24375607 chr4:120327624 NA 0.45 5.56 0.32 6.68e-8 Corneal astigmatism; CESC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC cis rs7940866 0.845 rs1991899 chr11:130801649 C/T cg12179176 chr11:130786555 SNX19 -0.56 -7.88 -0.44 8.74e-14 Schizophrenia; CESC cis rs77741769 0.571 rs61946382 chr12:121344574 A/T cg02419362 chr12:121203948 SPPL3 0.35 5.6 0.33 5.35e-8 Mean corpuscular volume; CESC cis rs9796 0.866 rs692155 chr15:41407061 A/G cg18705301 chr15:41695430 NDUFAF1 -0.4 -5.91 -0.34 1.04e-8 Menopause (age at onset); CESC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg00149659 chr3:10157352 C3orf10 0.7 8.47 0.46 1.68e-15 Alzheimer's disease; CESC cis rs2274273 0.773 rs8012380 chr14:55735010 T/G cg04306507 chr14:55594613 LGALS3 0.29 5.59 0.33 5.51e-8 Protein biomarker; CESC cis rs4654899 0.733 rs6698440 chr1:21258712 C/T cg05370193 chr1:21551575 ECE1 0.4 6.19 0.36 2.24e-9 Superior frontal gyrus grey matter volume; CESC cis rs9815354 1.000 rs1615543 chr3:41906404 C/T cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs4654899 0.772 rs12145203 chr1:21086127 C/T cg05370193 chr1:21551575 ECE1 0.34 5.05 0.3 8.26e-7 Superior frontal gyrus grey matter volume; CESC cis rs703842 1.000 rs10747783 chr12:58176614 T/C cg00677455 chr12:58241039 CTDSP2 0.54 7.02 0.4 1.9e-11 Multiple sclerosis; CESC cis rs72901758 0.768 rs72901762 chr17:76244926 A/G cg26068271 chr17:76253126 NA 0.48 7.33 0.41 2.85e-12 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19828298 chr1:3713105 LRRC47 0.46 6.58 0.37 2.48e-10 Systemic lupus erythematosus; CESC cis rs344364 0.511 rs337284 chr16:1954799 A/C cg03013636 chr16:1946785 NA 0.45 6.15 0.35 2.83e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs6674176 0.597 rs4031031 chr1:44393533 C/T cg12908607 chr1:44402522 ARTN -0.5 -7.66 -0.43 3.54e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs6964587 0.869 rs10278155 chr7:91532456 T/G cg17063962 chr7:91808500 NA -0.54 -7.19 -0.4 6.56e-12 Breast cancer; CESC cis rs9611519 0.780 rs2235850 chr22:41657626 C/T cg03806693 chr22:41940476 POLR3H -0.57 -6.51 -0.37 3.71e-10 Neuroticism; CESC cis rs3768617 0.510 rs3765521 chr1:183077615 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 13.2 0.63 6.62e-31 Fuchs's corneal dystrophy; CESC cis rs4074961 0.586 rs10908360 chr1:38058693 T/C cg13401533 chr1:37979913 MEAF6 0.53 7.05 0.4 1.6e-11 Axial length; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg14893161 chr1:205819251 PM20D1 1.02 19.9 0.77 1.57e-54 Menarche (age at onset); CESC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.7 -0.55 1.91e-22 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16635483 chr3:96338407 NA -0.67 -7.77 -0.43 1.73e-13 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg24209194 chr3:40518798 ZNF619 0.51 6.45 0.37 5.32e-10 Renal cell carcinoma; CESC cis rs4423214 0.879 rs1790345 chr11:71145941 G/A cg05163923 chr11:71159392 DHCR7 -0.61 -7.17 -0.4 7.67e-12 Vitamin D levels; CESC cis rs8072100 0.875 rs7208530 chr17:45544107 C/T cg25173405 chr17:45401733 C17orf57 -0.46 -6.03 -0.35 5.59e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs11638352 1.000 rs958485 chr15:44350065 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -5.35 -0.31 1.95e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs1801251 1.000 rs3817311 chr2:233612557 C/T cg08000102 chr2:233561755 GIGYF2 0.66 9.34 0.5 4.05e-18 Coronary artery disease; CESC cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg25019033 chr10:957182 NA -0.6 -6.22 -0.36 1.96e-9 Eosinophil percentage of granulocytes; CESC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6088580 0.634 rs6142159 chr20:32993035 G/A cg06115741 chr20:33292138 TP53INP2 -0.47 -6.08 -0.35 4.22e-9 Glomerular filtration rate (creatinine); CESC cis rs853679 0.599 rs149943 chr6:28002388 G/A cg20933634 chr6:27740509 NA 0.58 5.16 0.3 4.82e-7 Depression; CESC cis rs1797885 0.902 rs1699346 chr3:12504295 C/A cg26432171 chr3:12704882 RAF1 -0.5 -6.43 -0.37 5.83e-10 Immature fraction of reticulocytes; CESC cis rs4803468 1.000 rs284657 chr19:41929915 G/C cg14132834 chr19:41945861 ATP5SL -0.58 -7.17 -0.4 7.5e-12 Height; CESC cis rs2235544 0.565 rs928444 chr1:54473548 C/G cg25741118 chr1:54482237 LDLRAD1 0.25 6.28 0.36 1.41e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs654950 0.841 rs676383 chr1:41993753 C/T cg06885757 chr1:42089581 HIVEP3 -0.46 -7.21 -0.4 5.83e-12 Airway imaging phenotypes; CESC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg17221315 chr6:27791827 HIST1H4J 0.4 5.07 0.3 7.46e-7 Cardiac Troponin-T levels; CESC cis rs4919694 1.000 rs3740394 chr10:104634474 A/G cg04362960 chr10:104952993 NT5C2 0.82 6.94 0.39 2.97e-11 Arsenic metabolism; CESC cis rs10463316 0.604 rs28744577 chr5:150768983 A/T cg03212797 chr5:150827313 SLC36A1 -0.45 -5.88 -0.34 1.24e-8 Metabolite levels (Pyroglutamine); CESC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.52 7.61 0.42 4.8e-13 Menopause (age at onset); CESC trans rs208520 0.874 rs208456 chr6:66907942 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -9.69 -0.51 3.38e-19 Exhaled nitric oxide output; CESC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg23262073 chr20:60523788 NA 0.49 6.87 0.39 4.59e-11 Obesity-related traits; CESC trans rs1223629 1.000 rs11187804 chr10:95944627 G/A cg16346422 chr11:2920819 SLC22A18;SLC22A18AS 0.67 6.05 0.35 4.83e-9 Glucose homeostasis traits; CESC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg18876405 chr7:65276391 NA 0.51 5.96 0.34 8.21e-9 Aortic root size; CESC cis rs10751667 0.643 rs6597970 chr11:928669 C/A cg06064525 chr11:970664 AP2A2 -0.5 -9.87 -0.52 9.15e-20 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00746083 chr14:21905454 CHD8 -0.6 -6.54 -0.37 3.09e-10 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs2338800 chr17:37498149 C/G cg00129232 chr17:37814104 STARD3 0.52 6.79 0.38 7.52e-11 Glomerular filtration rate (creatinine); CESC cis rs6460942 0.908 rs59410610 chr7:12282847 A/G cg06484146 chr7:12443880 VWDE -0.54 -5.77 -0.33 2.26e-8 Coronary artery disease; CESC cis rs2197308 0.626 rs6581156 chr12:37858731 C/A cg26384229 chr12:38710491 ALG10B -0.56 -8.06 -0.44 2.59e-14 Morning vs. evening chronotype; CESC trans rs4950322 0.563 rs61838944 chr1:146581857 C/T cg04954894 chr8:38089920 DDHD2 -0.59 -6.42 -0.37 6.22e-10 Protein quantitative trait loci; CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg18632102 chr5:154238496 CNOT8 0.55 6.36 0.36 8.57e-10 Endometrial cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20554397 chr5:303564 PDCD6;AHRR -0.7 -8.16 -0.45 1.38e-14 Gut microbiome composition (summer); CESC cis rs9287719 0.904 rs55738250 chr2:10757132 G/A cg00105475 chr2:10696890 NA 0.37 5.4 0.31 1.52e-7 Prostate cancer; CESC cis rs425277 1.000 rs262672 chr1:2080813 G/T cg04315214 chr1:2043799 PRKCZ -0.38 -5.3 -0.31 2.42e-7 Height; CESC cis rs2797160 0.967 rs1739368 chr6:126011079 C/T cg05901451 chr6:126070800 HEY2 0.45 6.62 0.38 2e-10 Endometrial cancer; CESC cis rs2228479 0.718 rs11645376 chr16:89912281 G/C cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs4849845 0.637 rs4849851 chr2:121055910 A/C cg24070213 chr2:121070622 NA 0.42 6.1 0.35 3.78e-9 Mean platelet volume; CESC cis rs8141529 0.644 rs5752795 chr22:29178820 T/C cg02153584 chr22:29168773 CCDC117 0.69 9.9 0.52 7.13e-20 Lymphocyte counts; CESC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg07256732 chr16:621771 PIGQ -0.32 -5.66 -0.33 4e-8 Height; CESC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg18876405 chr7:65276391 NA 0.43 5.6 0.33 5.38e-8 Calcium levels; CESC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg05368731 chr17:41323189 NBR1 0.79 11.1 0.56 8.99e-24 Menopause (age at onset); CESC cis rs9611565 0.580 rs5758449 chr22:42140160 C/T cg06481639 chr22:41940642 POLR3H 0.5 5.81 0.34 1.78e-8 Vitiligo; CESC cis rs9916302 0.706 rs594794 chr17:37453485 T/C cg07936489 chr17:37558343 FBXL20 0.92 10.37 0.54 2.23e-21 Glomerular filtration rate (creatinine); CESC cis rs6963495 0.519 rs3892297 chr7:105152173 G/A cg19920283 chr7:105172520 RINT1 0.68 6.43 0.37 6.01e-10 Bipolar disorder (body mass index interaction); CESC cis rs67072384 0.818 rs2291291 chr11:72466897 T/C cg04827223 chr11:72435913 ARAP1 -0.7 -7.1 -0.4 1.16e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15554505 chr19:22123728 NA 0.38 6.1 0.35 3.76e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.48 -5.74 -0.33 2.54e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg24675658 chr1:53192096 ZYG11B 0.64 7.98 0.44 4.39e-14 Monocyte count; CESC cis rs6570726 0.791 rs6570692 chr6:145904401 T/A cg23711669 chr6:146136114 FBXO30 0.97 14.59 0.67 8.43e-36 Lobe attachment (rater-scored or self-reported); CESC trans rs11148252 0.624 rs6561682 chr13:53266297 A/G cg12121983 chr17:1387582 MYO1C -0.4 -6.05 -0.35 4.94e-9 Lewy body disease; CESC cis rs10851478 0.872 rs1911612 chr15:49830708 G/A cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg04315214 chr1:2043799 PRKCZ 0.53 9.14 0.49 1.72e-17 Height; CESC cis rs1941023 0.584 rs10750937 chr11:60172087 C/T cg08716584 chr11:60157161 MS4A7 -0.55 -9.03 -0.48 3.7e-17 Congenital heart disease (maternal effect); CESC cis rs9329289 0.510 rs2029604 chr10:2554700 T/C cg15501526 chr10:2543763 NA 0.47 7.49 0.42 1e-12 Age-related hearing impairment; CESC cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 3.05e-8 Mean platelet volume; CESC cis rs6968419 0.788 rs72603592 chr7:115831195 C/T cg02561103 chr7:115862891 TES -0.39 -5.26 -0.31 3.04e-7 Intraocular pressure; CESC cis rs651907 0.535 rs17412601 chr3:101499275 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 6.04 0.35 5.25e-9 Colorectal cancer; CESC cis rs9914578 1.000 rs62067978 chr17:2013058 G/A cg22021934 chr17:1358234 CRK 0.34 5.31 0.31 2.29e-7 Body mass index; CESC cis rs2228479 0.850 rs2238531 chr16:89856217 C/G cg19635926 chr16:89946313 TCF25 0.67 5.08 0.3 7.19e-7 Skin colour saturation; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01160766 chr17:72199871 RPL38 -0.49 -6.66 -0.38 1.57e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6088580 0.524 rs6088560 chr20:33228549 T/C cg08999081 chr20:33150536 PIGU -0.44 -6.19 -0.36 2.33e-9 Glomerular filtration rate (creatinine); CESC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg11764359 chr7:65958608 NA -0.78 -10.74 -0.55 1.44e-22 Aortic root size; CESC trans rs561341 1.000 rs554078 chr17:30330109 A/C cg20587970 chr11:113659929 NA -1.48 -19.5 -0.77 4.04e-53 Hip circumference adjusted for BMI; CESC cis rs9430161 0.644 rs34365965 chr1:11034442 G/A cg02454025 chr1:11042201 C1orf127 0.99 16.16 0.7 2.35e-41 Ewing sarcoma; CESC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg10691866 chr7:65817282 TPST1 -0.35 -5.62 -0.33 4.9e-8 Aortic root size; CESC cis rs4853525 0.522 rs10490538 chr2:191590066 C/T cg10560079 chr2:191398806 TMEM194B 0.42 5.36 0.31 1.78e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; CESC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs9896933 0.887 rs78483419 chr17:80870884 T/C cg20578329 chr17:80767326 TBCD -0.72 -7.3 -0.41 3.42e-12 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs858239 0.730 rs858290 chr7:23248036 A/G cg23682824 chr7:23144976 KLHL7 0.42 5.54 0.32 7.17e-8 Cerebrospinal fluid biomarker levels; CESC cis rs6732160 0.967 rs6760964 chr2:73387386 C/G cg01422370 chr2:73384389 NA 0.52 9.06 0.49 2.88e-17 Intelligence (multi-trait analysis); CESC cis rs854765 0.583 rs5002487 chr17:17832460 A/G cg04398451 chr17:18023971 MYO15A -0.62 -8.86 -0.48 1.16e-16 Total body bone mineral density; CESC cis rs897984 0.762 rs1870293 chr16:30970941 T/C cg00531865 chr16:30841666 NA 0.48 6.31 0.36 1.16e-9 Dementia with Lewy bodies; CESC cis rs4803468 1.000 rs2241706 chr19:41912807 A/G cg09537434 chr19:41945824 ATP5SL -1.09 -19.79 -0.77 3.84e-54 Height; CESC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg18876405 chr7:65276391 NA 0.49 6.42 0.37 6.43e-10 Aortic root size; CESC cis rs7555523 0.887 rs6696454 chr1:165707923 T/C cg24409356 chr1:165738333 TMCO1 0.97 8.67 0.47 4.48e-16 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs4853012 0.793 rs6723185 chr2:74344884 T/A cg20891558 chr2:74357851 NA 0.84 12.26 0.6 1.12e-27 Gestational age at birth (maternal effect); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg16998327 chr1:184020984 TSEN15 0.48 6.21 0.36 2.01e-9 Breast cancer;Type 2 diabetes; CESC cis rs2124969 0.548 rs7586751 chr2:160958145 T/C cg03641300 chr2:160917029 PLA2R1 -0.57 -5.72 -0.33 2.87e-8 Waist circumference adjusted for body mass index; CESC trans rs2623325 0.874 rs11711371 chr3:99109345 G/C cg19595760 chr1:25948511 MAN1C1 -0.48 -6.34 -0.36 9.63e-10 Optic cup area;Vertical cup-disc ratio; CESC cis rs4253772 0.591 rs7291444 chr22:46656246 T/G cg09491104 chr22:46646882 C22orf40 -0.57 -8.75 -0.47 2.58e-16 LDL cholesterol;Cholesterol, total; CESC cis rs72781680 1.000 rs72798417 chr2:24188656 C/T cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.56e-8 Lymphocyte counts; CESC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg14403583 chr14:105418241 AHNAK2 -0.57 -7.86 -0.43 9.9e-14 Rheumatoid arthritis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20503117 chr3:5164013 ARL8B -0.44 -6.22 -0.36 1.98e-9 Gambling; CESC cis rs9303401 0.646 rs7217845 chr17:57236900 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.56 7.32 0.41 2.93e-12 Cognitive test performance; CESC cis rs2050392 0.799 rs303429 chr10:30708441 C/T cg18806716 chr10:30721971 MAP3K8 -0.42 -5.98 -0.35 7.05e-9 Inflammatory bowel disease; CESC cis rs10200850 0.881 rs950225 chr2:240258244 C/T cg26975040 chr2:240205772 HDAC4 -0.65 -5.19 -0.3 4.26e-7 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs9399401 0.601 rs171891 chr6:142850612 G/A cg04461802 chr6:142623433 GPR126 0.4 5.58 0.32 5.87e-8 Chronic obstructive pulmonary disease; CESC cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6788895 1.000 rs76801042 chr3:150482720 A/C cg07663535 chr3:150480033 SIAH2 0.72 5.09 0.3 6.94e-7 Breast cancer; CESC cis rs2346177 0.576 rs1530621 chr2:46688688 T/C cg02822958 chr2:46747628 ATP6V1E2 0.44 5.47 0.32 1.03e-7 HDL cholesterol; CESC cis rs1023500 0.551 rs2859438 chr22:42466980 A/T cg04733989 chr22:42467013 NAGA 0.83 12.62 0.61 6.7e-29 Schizophrenia; CESC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg11987759 chr7:65425863 GUSB 0.42 5.8 0.34 1.84e-8 Calcium levels; CESC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg19346786 chr7:2764209 NA -0.51 -7.14 -0.4 8.86e-12 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04619800 chr15:83654972 FAM103A1 -0.48 -6.38 -0.36 8.07e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg02487422 chr3:49467188 NICN1 0.39 5.27 0.31 2.78e-7 Menarche (age at onset); CESC cis rs2243480 0.901 rs57126451 chr7:65416306 T/C cg12463550 chr7:65579703 CRCP 0.68 5.63 0.33 4.48e-8 Diabetic kidney disease; CESC cis rs8072100 0.713 rs9899859 chr17:45513049 A/G cg08085267 chr17:45401833 C17orf57 -0.52 -6.6 -0.38 2.28e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7927771 0.839 rs7124681 chr11:47529947 C/A cg20307385 chr11:47447363 PSMC3 -0.4 -5.04 -0.3 8.81e-7 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21156815 chr8:22526736 BIN3 0.63 7.37 0.41 2.11e-12 Gut microbiome composition (summer); CESC cis rs11229555 0.645 rs12226725 chr11:58246332 G/A cg15696309 chr11:58395628 NA -0.44 -5.27 -0.31 2.88e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs7772486 0.686 rs4896827 chr6:145953338 T/A cg05347473 chr6:146136440 FBXO30 0.57 7.4 0.41 1.83e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1153858 1.000 rs2668747 chr15:45617216 T/C cg21132104 chr15:45694354 SPATA5L1 0.77 10.36 0.54 2.41e-21 Homoarginine levels; CESC cis rs60154123 0.772 rs701944 chr1:210417098 G/A cg22029157 chr1:209979665 IRF6 0.51 5.7 0.33 3.12e-8 Coronary artery disease; CESC cis rs7914558 0.966 rs10786727 chr10:104698523 G/A cg04362960 chr10:104952993 NT5C2 0.43 5.53 0.32 7.76e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1881797 1.000 rs10925069 chr1:247681313 C/T cg18198730 chr1:247681584 NA -0.65 -8.7 -0.47 3.67e-16 Acute lymphoblastic leukemia (childhood); CESC trans rs958685 0.766 rs7561997 chr2:70716048 C/T cg20996124 chr1:1144203 NA -0.4 -6.03 -0.35 5.58e-9 Hand grip strength; CESC cis rs13106227 0.550 rs4859673 chr4:77364799 A/G cg20311846 chr4:77356250 SHROOM3 -0.32 -6.07 -0.35 4.3e-9 Eosinophilic esophagitis (pediatric); CESC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg21724239 chr8:58056113 NA 0.57 5.94 0.34 9.1e-9 Developmental language disorder (linguistic errors); CESC cis rs116095464 0.558 rs62346508 chr5:203668 T/C cg22496380 chr5:211416 CCDC127 -0.95 -9.99 -0.52 3.65e-20 Breast cancer; CESC cis rs59918340 0.728 rs59172574 chr8:142231945 C/G cg23750338 chr8:142222470 SLC45A4 0.64 9.86 0.52 9.5e-20 Immature fraction of reticulocytes; CESC cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg06212747 chr3:49208901 KLHDC8B 0.71 9.31 0.5 5.11e-18 Parkinson's disease; CESC cis rs2243480 1.000 rs10950032 chr7:65738591 C/A cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs11229555 0.645 rs11229489 chr11:58244917 A/G cg15696309 chr11:58395628 NA -0.44 -5.23 -0.31 3.47e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs7267979 1.000 rs6050599 chr20:25400240 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.03 -0.74 5.66e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs10883723 0.810 rs1884929 chr10:104275418 C/T cg22532475 chr10:104410764 TRIM8 -0.33 -5.68 -0.33 3.5e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7666738 0.710 rs7674407 chr4:98838522 A/G cg05340658 chr4:99064831 C4orf37 0.7 9.73 0.51 2.46e-19 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01145475 chr6:7313460 SSR1 0.57 6.16 0.35 2.62e-9 Gut microbiome composition (summer); CESC cis rs6540556 0.736 rs2076152 chr1:209936060 A/G cg05527609 chr1:210001259 C1orf107 -0.42 -5.32 -0.31 2.18e-7 Red blood cell count; CESC cis rs2425143 1.000 rs113203744 chr20:34253656 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -7.54 -0.42 7.65e-13 Blood protein levels; CESC cis rs7666738 0.830 rs9998682 chr4:98939009 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -6.7 -0.38 1.27e-10 Total body bone mineral density; CESC trans rs10411161 0.702 rs7247017 chr19:52391769 T/C cg22319618 chr22:45562946 NUP50 -0.74 -7.44 -0.42 1.37e-12 Breast cancer; CESC cis rs748404 0.560 rs689797 chr15:43826557 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.53 6.76 0.38 8.53e-11 Lung cancer; CESC cis rs2573652 0.723 rs2727201 chr15:100515311 A/G cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.39 -0.31 1.58e-7 Height; CESC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg22903471 chr2:27725779 GCKR -0.45 -6.26 -0.36 1.53e-9 Total body bone mineral density; CESC cis rs6748734 0.901 rs6720357 chr2:241830296 A/C cg15164180 chr2:241846931 NA -0.35 -5.16 -0.3 4.87e-7 Urinary metabolites; CESC cis rs926938 0.552 rs360613 chr1:115394864 C/G cg12756093 chr1:115239321 AMPD1 0.51 7.18 0.4 7.17e-12 Autism; CESC cis rs1775715 0.737 rs55859032 chr10:32213239 C/T cg26784012 chr10:32216390 ARHGAP12 0.39 5.11 0.3 6.18e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg01577865 chr5:176854009 GRK6 0.44 6.27 0.36 1.48e-9 Myopia (pathological); CESC cis rs4728302 0.838 rs7798804 chr7:133584085 C/T cg10665199 chr7:133106180 EXOC4 0.4 5.5 0.32 8.86e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs12824058 0.831 rs12320318 chr12:130812335 T/C cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs10992471 0.651 rs13296623 chr9:95301627 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.41 -5.16 -0.3 4.93e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg00074818 chr8:8560427 CLDN23 0.37 5.45 0.32 1.16e-7 Obesity-related traits; CESC cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg05343316 chr1:45956843 TESK2 -0.5 -6.46 -0.37 5.09e-10 High light scatter reticulocyte count; CESC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.43e-21 Prudent dietary pattern; CESC cis rs7267979 0.966 rs7270835 chr20:25435067 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.84 16.15 0.7 2.53e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs9388451 0.626 rs3799712 chr6:126075103 A/G cg05901451 chr6:126070800 HEY2 -0.62 -9.32 -0.5 4.81e-18 Brugada syndrome; CESC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg13012494 chr21:47604986 C21orf56 0.41 5.43 0.32 1.3e-7 Testicular germ cell tumor; CESC cis rs12142240 0.698 rs55670684 chr1:46835139 C/T cg10495392 chr1:46806563 NSUN4 0.58 6.07 0.35 4.34e-9 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00155844 chr15:28394612 HERC2 -0.66 -7.64 -0.42 4.08e-13 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.41 -0.32 1.43e-7 Developmental language disorder (linguistic errors); CESC cis rs909674 0.865 rs5757683 chr22:39850174 G/A cg02038168 chr22:39784481 NA -0.65 -7.99 -0.44 4.22e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9796 0.663 rs11853192 chr15:41368515 G/A cg18705301 chr15:41695430 NDUFAF1 -0.47 -6.94 -0.39 3.09e-11 Menopause (age at onset); CESC cis rs9811920 0.809 rs793476 chr3:99541747 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.44 -7.27 -0.41 3.99e-12 Axial length; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18727501 chr4:89513542 HERC3 -0.45 -6.15 -0.35 2.79e-9 Ulcerative colitis; CESC cis rs9811920 0.609 rs793462 chr3:99616461 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17655527 chr19:56128027 NA -0.62 -6.64 -0.38 1.77e-10 Gut microbiome composition (summer); CESC cis rs7312933 0.558 rs11181466 chr12:42765181 A/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.34 0.36 9.95e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs9840812 0.728 rs12630999 chr3:136300927 G/A cg15507776 chr3:136538369 TMEM22 0.43 5.25 0.31 3.18e-7 Fibrinogen levels; CESC cis rs28489187 0.683 rs233093 chr1:85823120 C/T cg16011679 chr1:85725395 C1orf52 0.47 5.43 0.32 1.27e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg06808227 chr14:105710500 BRF1 -0.6 -6.91 -0.39 3.55e-11 Mean platelet volume;Platelet distribution width; CESC cis rs11792861 0.589 rs2176692 chr9:111927723 G/A cg05043794 chr9:111880884 C9orf5 -0.44 -7.16 -0.4 7.81e-12 Menarche (age at onset); CESC cis rs2730245 0.528 rs1188954 chr7:158691417 G/A cg14689365 chr7:158441557 NCAPG2 0.41 5.11 0.3 6.07e-7 Height; CESC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs9300255 0.512 rs2851436 chr12:123667354 G/T cg00376283 chr12:123451042 ABCB9 0.71 8.71 0.47 3.27e-16 Neutrophil percentage of white cells; CESC cis rs11167764 0.945 rs891991 chr5:141484977 A/T cg08523384 chr5:141488047 NDFIP1 -0.37 -5.49 -0.32 9.48e-8 Crohn's disease; CESC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.83 0.65 4.07e-33 Prudent dietary pattern; CESC cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs3125734 0.653 rs1007976 chr10:63970144 C/T cg09941381 chr10:64027924 RTKN2 0.31 5.11 0.3 6.14e-7 Rheumatoid arthritis; CESC trans rs9325144 0.647 rs12227834 chr12:38849246 G/C cg10679878 chr6:156759499 NA -0.33 -6.0 -0.35 6.61e-9 Morning vs. evening chronotype; CESC cis rs425277 0.958 rs7546523 chr1:2043792 G/A cg24578937 chr1:2090814 PRKCZ 0.54 8.93 0.48 7.07e-17 Height; CESC trans rs6011002 1.000 rs6010614 chr20:62300906 G/C cg02961472 chr15:70340064 NA 0.57 6.16 0.35 2.68e-9 Dental caries; CESC cis rs7772486 0.846 rs1854901 chr6:146325685 T/C cg23711669 chr6:146136114 FBXO30 0.79 11.12 0.56 7.65e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs11677416 1.000 rs1878318 chr2:113545185 A/G cg27083787 chr2:113543245 IL1A 0.61 7.53 0.42 7.75e-13 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs2019216 0.542 rs1987424 chr17:21874036 G/A cg22648282 chr17:21454238 C17orf51 -0.41 -5.29 -0.31 2.61e-7 Pelvic organ prolapse; CESC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg04414720 chr1:150670196 GOLPH3L 0.54 7.58 0.42 5.66e-13 Tonsillectomy; CESC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg15145296 chr3:125709740 NA -0.5 -5.65 -0.33 4.04e-8 Blood pressure (smoking interaction); CESC cis rs11098499 0.866 rs3756156 chr4:120524841 G/A cg09307838 chr4:120376055 NA 0.88 12.11 0.6 3.6e-27 Corneal astigmatism; CESC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg05483915 chr17:80145575 CCDC57 0.45 5.38 0.31 1.63e-7 Breast cancer; CESC cis rs7605378 0.567 rs717915 chr2:200714766 C/T cg17644776 chr2:200775616 C2orf69 0.55 6.65 0.38 1.65e-10 Osteoporosis; CESC cis rs4835473 0.932 rs35947648 chr4:144656245 G/A cg25736465 chr4:144833511 NA -0.33 -5.3 -0.31 2.48e-7 Immature fraction of reticulocytes; CESC cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg02487422 chr3:49467188 NICN1 0.47 5.85 0.34 1.42e-8 Parkinson's disease; CESC cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg26408565 chr15:76604113 ETFA -0.42 -6.21 -0.36 2e-9 Blood metabolite levels; CESC trans rs11098499 0.588 rs6534149 chr4:120559292 T/G cg25214090 chr10:38739885 LOC399744 -0.57 -8.11 -0.45 1.87e-14 Corneal astigmatism; CESC cis rs2777491 0.574 rs28700583 chr15:41714072 C/T cg18705301 chr15:41695430 NDUFAF1 -1.08 -17.44 -0.73 7.01e-46 Ulcerative colitis; CESC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg06221963 chr1:154839813 KCNN3 -0.71 -12.38 -0.61 4.56e-28 Prostate cancer; CESC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg14159672 chr1:205819179 PM20D1 0.79 12.1 0.6 4.05e-27 Menarche (age at onset); CESC cis rs10504073 0.647 rs11997959 chr8:50014044 C/T cg00325661 chr8:49890786 NA 0.52 7.95 0.44 5.53e-14 Blood metabolite ratios; CESC cis rs698813 0.774 rs786625 chr2:44604156 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.41 0.32 1.43e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs9287719 0.601 rs759401 chr2:10709922 G/A cg00105475 chr2:10696890 NA 0.41 5.65 0.33 4.24e-8 Prostate cancer; CESC cis rs2228479 0.850 rs45567439 chr16:89814604 G/A cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16714616 chr20:40247229 CHD6 -0.62 -7.33 -0.41 2.87e-12 Gut microbiome composition (summer); CESC cis rs2562152 0.530 rs216604 chr16:112513 T/C cg02949481 chr16:131562 MPG 0.63 6.36 0.36 8.71e-10 Glioblastoma; CESC cis rs6754311 0.731 rs1470457 chr2:136581848 A/G cg07169764 chr2:136633963 MCM6 0.65 8.16 0.45 1.39e-14 Mosquito bite size; CESC cis rs8099014 0.861 rs6566969 chr18:56118999 A/G cg19312305 chr18:56117016 MIR122 -0.27 -5.4 -0.31 1.5e-7 Platelet count; CESC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.03e-11 Tonsillectomy; CESC cis rs9473147 0.543 rs9367279 chr6:47448336 A/G cg20196966 chr6:47445060 CD2AP 0.4 5.1 0.3 6.36e-7 Platelet distribution width;Mean platelet volume; CESC cis rs7216064 0.953 rs11868959 chr17:65840810 T/C cg12091567 chr17:66097778 LOC651250 -0.86 -8.83 -0.48 1.49e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg20811857 chr17:78079795 GAA -0.38 -5.86 -0.34 1.36e-8 Yeast infection; CESC cis rs4523957 0.855 rs9893573 chr17:2126003 A/G cg16513277 chr17:2031491 SMG6 -0.6 -8.12 -0.45 1.72e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08089031 chr6:139456240 HECA 0.62 7.34 0.41 2.65e-12 Gut microbiome composition (summer); CESC trans rs9325144 0.534 rs4882350 chr12:38686979 A/G cg23762105 chr12:34175262 ALG10 -0.46 -6.15 -0.35 2.77e-9 Morning vs. evening chronotype; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22571926 chr5:56112222 MAP3K1 -0.48 -6.56 -0.37 2.8e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs523522 0.673 rs643372 chr12:121022640 C/G cg27279351 chr12:120934652 DYNLL1 0.7 9.06 0.49 2.86e-17 High light scatter reticulocyte count; CESC cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 3.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4561483 0.551 rs1126889 chr16:12061910 C/G cg08843971 chr16:11963173 GSPT1 -0.39 -5.32 -0.31 2.25e-7 Testicular germ cell tumor; CESC cis rs6546550 0.901 rs10496174 chr2:70153436 T/G cg02498382 chr2:70120550 SNRNP27 -0.4 -6.88 -0.39 4.23e-11 Prevalent atrial fibrillation; CESC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg22823121 chr1:150693482 HORMAD1 0.4 5.68 0.33 3.61e-8 Melanoma; CESC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg14703610 chr5:56206110 C5orf35 -0.4 -5.2 -0.3 4.08e-7 Initial pursuit acceleration; CESC cis rs7639513 0.737 rs13070228 chr3:12706914 G/A cg23032965 chr3:12705835 RAF1 0.76 10.8 0.55 8.99e-23 Itch intensity from mosquito bite; CESC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg09455208 chr3:40491958 NA 0.51 8.27 0.45 6.59e-15 Renal cell carcinoma; CESC cis rs698833 0.521 rs35627501 chr2:44506971 G/C cg04920474 chr2:44395004 PPM1B 0.48 6.8 0.39 6.87e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7208859 0.673 rs8077116 chr17:29140162 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg19723775 chr5:179050963 HNRNPH1 0.41 5.46 0.32 1.08e-7 Lung cancer; CESC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg08470875 chr2:26401718 FAM59B -0.55 -6.0 -0.35 6.49e-9 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs602688 chr17:37439496 C/T cg15445000 chr17:37608096 MED1 0.39 6.53 0.37 3.36e-10 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg24818145 chr4:99064322 C4orf37 -0.4 -5.19 -0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg13902645 chr11:5959945 NA -0.67 -9.43 -0.5 2.19e-18 DNA methylation (variation); CESC cis rs6570726 0.935 rs387965 chr6:145869366 A/G cg05347473 chr6:146136440 FBXO30 0.45 5.98 0.34 7.1e-9 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23209459 chr19:56652545 ZNF444 -0.46 -6.02 -0.35 5.69e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg08684580 chr7:98029266 BAIAP2L1 0.35 5.78 0.33 2.08e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg18252515 chr7:66147081 NA 0.39 5.08 0.3 7.05e-7 Aortic root size; CESC trans rs10463316 0.894 rs7729438 chr5:150762197 G/A cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -8.16 -0.45 1.33e-14 Hemoglobin concentration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18663499 chr3:118959852 B4GALT4 -0.43 -6.68 -0.38 1.42e-10 Gambling; CESC cis rs2933343 0.729 rs6790091 chr3:128608751 G/C cg25356066 chr3:128598488 ACAD9 0.66 9.18 0.49 1.27e-17 IgG glycosylation; CESC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg18350739 chr11:68623251 NA -0.44 -6.73 -0.38 1.02e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.88 0.48 1.03e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6582630 0.555 rs1829583 chr12:38423161 T/C cg13010199 chr12:38710504 ALG10B -0.42 -5.52 -0.32 8.07e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg17986463 chr6:150326316 RAET1K -0.49 -6.32 -0.36 1.12e-9 Recombination measurement; CESC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg16680214 chr1:154839983 KCNN3 -0.47 -7.4 -0.41 1.82e-12 Prostate cancer; CESC cis rs8070624 0.543 rs7219320 chr17:17880877 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.06 0.44 2.64e-14 Total body bone mineral density; CESC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg19622623 chr12:86230825 RASSF9 -0.42 -5.13 -0.3 5.64e-7 Major depressive disorder; CESC cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.78 8.84 0.48 1.4e-16 Alzheimer's disease; CESC cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg03467027 chr4:99064603 C4orf37 0.45 5.67 0.33 3.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9399137 0.507 rs4896129 chr6:135349845 C/T cg24558204 chr6:135376177 HBS1L 0.71 10.05 0.53 2.38e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs897080 0.515 rs786401 chr2:44712069 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.24 0.31 3.34e-7 Height; CESC cis rs7851660 0.874 rs10122541 chr9:100628268 G/A cg13688889 chr9:100608707 NA -0.63 -8.87 -0.48 1.09e-16 Strep throat; CESC cis rs7851660 0.809 rs7037324 chr9:100658318 A/G cg13688889 chr9:100608707 NA -0.61 -8.64 -0.47 5.47e-16 Strep throat; CESC cis rs11997175 0.625 rs7018213 chr8:33625770 T/C ch.8.33884649F chr8:33765107 NA 0.54 6.82 0.39 6.18e-11 Body mass index; CESC trans rs2832077 0.527 rs2776210 chr21:30268558 A/G cg14791747 chr16:20752902 THUMPD1 -0.48 -6.6 -0.38 2.18e-10 Cognitive test performance; CESC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg15664640 chr17:80829946 TBCD 0.56 8.42 0.46 2.37e-15 Breast cancer; CESC cis rs7666738 0.753 rs28463863 chr4:98844444 T/C cg17366294 chr4:99064904 C4orf37 0.54 7.19 0.4 6.68e-12 Colonoscopy-negative controls vs population controls; CESC cis rs6570726 0.935 rs366308 chr6:145814532 T/A cg05347473 chr6:146136440 FBXO30 0.5 6.71 0.38 1.15e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg19077165 chr18:44547161 KATNAL2 -0.54 -7.93 -0.44 6.27e-14 Personality dimensions; CESC trans rs10463316 0.894 rs12652733 chr5:150753999 G/A cg24389359 chr12:111284228 CCDC63 -0.35 -6.17 -0.35 2.52e-9 Metabolite levels (Pyroglutamine); CESC cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg03709012 chr19:19516395 GATAD2A 1.01 15.33 0.69 2.07e-38 Tonsillectomy; CESC cis rs17666538 0.792 rs1703912 chr8:600643 A/G cg23958373 chr8:599963 NA 0.77 6.19 0.36 2.33e-9 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19981660 chr12:132434166 EP400 0.66 7.95 0.44 5.56e-14 Gut microbiome composition (summer); CESC cis rs1957429 0.901 rs1467571 chr14:65347682 C/T cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07277190 chr12:48723631 H1FNT -0.58 -6.37 -0.36 8.28e-10 Gut microbiome composition (summer); CESC cis rs1957429 0.520 rs66511472 chr14:65330330 C/A cg23373153 chr14:65346875 NA -0.74 -5.87 -0.34 1.33e-8 Pediatric areal bone mineral density (radius); CESC cis rs79349575 0.716 rs46522 chr17:46988597 C/T cg16584676 chr17:46985605 UBE2Z 0.5 5.8 0.34 1.88e-8 Type 2 diabetes; CESC cis rs10791097 0.694 rs1893018 chr11:130756632 T/C cg12179176 chr11:130786555 SNX19 0.65 10.22 0.53 6.73e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg13628971 chr7:2884303 GNA12 0.59 7.61 0.42 4.77e-13 Height; CESC cis rs6840258 1.000 rs72667759 chr4:87952199 C/G cg08197287 chr4:87952173 AFF1 -0.4 -5.37 -0.31 1.7e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs3020736 0.500 rs7292241 chr22:42492063 G/A cg15557168 chr22:42548783 NA 0.44 6.1 0.35 3.82e-9 Autism spectrum disorder or schizophrenia; CESC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg19193384 chr17:30244184 NA 0.53 5.68 0.33 3.55e-8 Hip circumference adjusted for BMI; CESC cis rs2239547 0.522 rs2581779 chr3:53056199 T/C cg11645453 chr3:52864694 ITIH4 -0.32 -5.11 -0.3 6.21e-7 Schizophrenia; CESC cis rs965469 1.000 rs6037583 chr20:3360632 G/A cg25506879 chr20:3388711 C20orf194 -0.58 -6.15 -0.35 2.83e-9 IFN-related cytopenia; CESC cis rs1371867 0.764 rs1020171 chr8:101288610 T/C cg11906718 chr8:101322791 RNF19A 0.5 6.41 0.37 6.67e-10 Atrioventricular conduction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12454419 chr4:77135195 SCARB2 0.57 7.04 0.4 1.62e-11 Gut microbiome composition (summer); CESC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg04553112 chr3:125709451 NA -0.54 -5.75 -0.33 2.4e-8 Blood pressure (smoking interaction); CESC cis rs16854884 0.586 rs6795008 chr3:143738421 A/G cg01302019 chr3:143689584 C3orf58 -0.32 -5.07 -0.3 7.32e-7 Economic and political preferences (feminism/equality); CESC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg26335602 chr6:28129616 ZNF389 0.44 5.7 0.33 3.25e-8 Parkinson's disease; CESC cis rs4268898 0.662 rs2303292 chr2:24432138 C/T cg06627628 chr2:24431161 ITSN2 -1.02 -11.2 -0.57 4.2e-24 Asthma; CESC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg16325326 chr1:53192061 ZYG11B 0.8 13.36 0.63 1.79e-31 Monocyte count; CESC cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg18180107 chr4:99064573 C4orf37 0.41 5.07 0.3 7.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 0.629 rs12929744 chr16:89493580 G/C cg00750074 chr16:89608354 SPG7 -0.42 -5.56 -0.32 6.53e-8 Multiple myeloma (IgH translocation); CESC cis rs5498 0.869 rs892188 chr19:10409793 A/G cg21994045 chr19:10403936 ICAM5 -0.43 -6.08 -0.35 4.17e-9 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26865258 chr19:47551991 TMEM160 0.49 6.18 0.35 2.43e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26726589 chr20:306364 SOX12 0.47 6.59 0.38 2.34e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9487051 0.735 rs1260594 chr6:109519891 A/C cg01475377 chr6:109611718 NA -0.37 -5.55 -0.32 6.99e-8 Reticulocyte fraction of red cells; CESC cis rs6088580 0.524 rs6087612 chr20:33230822 T/G cg07148914 chr20:33460835 GGT7 -0.4 -5.06 -0.3 7.78e-7 Glomerular filtration rate (creatinine); CESC cis rs3105593 0.563 rs7178070 chr15:50974496 C/T cg08437265 chr15:50716283 USP8 0.4 5.15 0.3 5e-7 QT interval; CESC cis rs7615952 0.673 rs9841194 chr3:125635739 C/T cg05084668 chr3:125655381 ALG1L -0.77 -7.77 -0.43 1.75e-13 Blood pressure (smoking interaction); CESC cis rs2228479 1.000 rs62052186 chr16:89969567 A/T cg14709524 chr16:89940631 TCF25 0.86 6.25 0.36 1.66e-9 Skin colour saturation; CESC cis rs6942756 0.806 rs2566877 chr7:128897317 G/A cg02491457 chr7:128862824 NA 0.65 9.72 0.51 2.71e-19 White matter hyperintensity burden; CESC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg14829155 chr15:31115871 NA 0.7 10.22 0.53 7.16e-21 Huntington's disease progression; CESC cis rs929354 0.772 rs4716460 chr7:156970054 T/C cg05182265 chr7:156933206 UBE3C -0.5 -7.3 -0.41 3.28e-12 Body mass index; CESC cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg00255919 chr5:131827918 IRF1 0.35 5.17 0.3 4.69e-7 Breast cancer;Mosquito bite size; CESC cis rs9929218 0.551 rs2296405 chr16:68721470 C/T cg02972257 chr16:68554789 NA 0.42 5.13 0.3 5.5e-7 Colorectal cancer; CESC cis rs3820068 0.581 rs6666373 chr1:15939884 A/T cg16988262 chr1:15930761 NA 0.34 5.52 0.32 7.98e-8 Systolic blood pressure; CESC cis rs1707322 1.000 rs4660318 chr1:46334876 A/G cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7000551 0.751 rs2100291 chr8:22374551 C/T cg12081754 chr8:22256438 SLC39A14 0.42 5.6 0.33 5.45e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg26335602 chr6:28129616 ZNF389 0.38 5.52 0.32 7.89e-8 Cardiac Troponin-T levels; CESC cis rs2463822 1.000 rs2513076 chr11:62103711 A/G cg06239285 chr11:62104954 ASRGL1 0.89 8.97 0.48 5.69e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs12142240 0.698 rs66516678 chr1:46810112 G/T cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs16867321 0.639 rs12466770 chr2:181441312 C/G cg23363182 chr2:181467187 NA 0.49 7.26 0.41 4.25e-12 Obesity; CESC cis rs2204008 0.616 rs1607852 chr12:38398125 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.68 0.38 1.41e-10 Bladder cancer; CESC cis rs7408868 0.764 rs62113791 chr19:15277009 C/T cg14696996 chr19:15285081 NOTCH3 1.11 11.51 0.58 3.92e-25 Pulse pressure; CESC cis rs6665290 0.904 rs12409428 chr1:227189969 T/C cg10327440 chr1:227177885 CDC42BPA -1.22 -32.58 -0.89 1.11e-94 Myeloid white cell count; CESC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg23754390 chr11:835074 CD151 0.32 5.77 0.33 2.24e-8 Mean platelet volume; CESC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg02725872 chr8:58115012 NA -0.34 -5.09 -0.3 6.69e-7 Developmental language disorder (linguistic errors); CESC cis rs17655565 0.636 rs73311144 chr12:52717544 G/A cg08257133 chr12:52711352 KRT83 0.37 5.22 0.31 3.58e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs11785400 0.793 rs4736362 chr8:143741381 G/A cg10596483 chr8:143751796 JRK 0.41 5.26 0.31 3.03e-7 Schizophrenia; CESC cis rs295140 0.546 rs295134 chr2:201110223 A/G cg23649088 chr2:200775458 C2orf69 -0.42 -5.48 -0.32 9.82e-8 QT interval; CESC cis rs6964587 0.967 rs10279210 chr7:91616891 G/A cg17063962 chr7:91808500 NA 0.56 7.66 0.43 3.61e-13 Breast cancer; CESC cis rs7178572 0.568 rs12901739 chr15:77395491 C/T cg22256960 chr15:77711686 NA -0.54 -6.86 -0.39 4.85e-11 Type 2 diabetes; CESC cis rs1790761 0.505 rs17593068 chr11:67350932 G/T cg00290607 chr11:67383545 NA -0.36 -5.33 -0.31 2.14e-7 Mean corpuscular volume; CESC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg24829409 chr8:58192753 C8orf71 -0.75 -9.71 -0.51 2.88e-19 Developmental language disorder (linguistic errors); CESC cis rs4613509 1 rs4613509 chr3:160728059 T/C cg04691961 chr3:161091175 C3orf57 -0.39 -5.2 -0.3 3.97e-7 Morning vs. evening chronotype; CESC cis rs2797160 0.904 rs2326292 chr6:125999674 G/A cg05901451 chr6:126070800 HEY2 -0.48 -7.04 -0.4 1.6e-11 Endometrial cancer; CESC cis rs4803468 1.000 rs4803463 chr19:41911040 C/G cg14132834 chr19:41945861 ATP5SL -0.63 -7.89 -0.44 8.04e-14 Height; CESC cis rs7772486 0.875 rs2748485 chr6:146332421 T/C cg23711669 chr6:146136114 FBXO30 0.81 11.57 0.58 2.49e-25 Lobe attachment (rater-scored or self-reported); CESC trans rs10953454 1.000 rs10272668 chr7:104494565 A/C cg04245439 chr3:142607978 PCOLCE2 -0.76 -6.14 -0.35 2.96e-9 Obesity; CESC cis rs4268898 0.662 rs2891382 chr2:24511491 C/G cg20701182 chr2:24300061 SF3B14 0.62 6.85 0.39 5.2e-11 Asthma; CESC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg10541313 chr22:46663664 TTC38 0.67 5.9 0.34 1.1e-8 LDL cholesterol;Cholesterol, total; CESC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg00815214 chr21:47717953 NA -0.37 -5.51 -0.32 8.6e-8 Testicular germ cell tumor; CESC cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg17427002 chr7:12443146 VWDE -0.44 -5.04 -0.3 8.59e-7 Coronary artery disease; CESC cis rs425277 1.000 rs421992 chr1:2077260 C/T cg16545954 chr1:2118288 C1orf86 0.33 5.62 0.33 4.82e-8 Height; CESC cis rs4474465 0.850 rs10793323 chr11:78244170 C/T cg27205649 chr11:78285834 NARS2 0.43 5.28 0.31 2.65e-7 Alzheimer's disease (survival time); CESC cis rs12541635 0.966 rs16873989 chr8:106966381 C/T cg10147462 chr8:107024639 NA 0.39 5.34 0.31 2.02e-7 Age of smoking initiation; CESC cis rs6800768 0.663 rs7428009 chr3:24094151 A/C cg10674438 chr3:24145617 LOC152024 -0.43 -5.84 -0.34 1.5e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6912958 0.712 rs2754260 chr6:88397666 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.35 -5.61 -0.33 5.2e-8 Monocyte percentage of white cells; CESC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.15 0.4 8.48e-12 Height; CESC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg00908189 chr16:619842 PIGQ 0.64 9.06 0.49 2.94e-17 Height; CESC cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg04756594 chr16:24857601 SLC5A11 -0.38 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC cis rs7829975 0.714 rs60315134 chr8:8670599 A/G cg06636001 chr8:8085503 FLJ10661 0.42 5.5 0.32 9.11e-8 Mood instability; CESC cis rs9488822 0.676 rs10456902 chr6:116333742 C/G cg05304507 chr6:116381966 FRK -0.26 -6.68 -0.38 1.44e-10 Cholesterol, total;LDL cholesterol; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03604796 chr7:134896227 WDR91 -0.51 -6.94 -0.39 3.04e-11 Fibrinogen levels; CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.47 7.42 0.41 1.59e-12 Bipolar disorder; CESC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.6 -8.57 -0.47 8.76e-16 Bipolar disorder; CESC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12188164 0.543 rs890972 chr5:462465 C/A cg16584290 chr5:462447 EXOC3 0.47 7.09 0.4 1.19e-11 Cystic fibrosis severity; CESC cis rs4423214 0.879 rs4945008 chr11:71221248 A/G cg05163923 chr11:71159392 DHCR7 0.79 10.87 0.56 5.22e-23 Vitamin D levels; CESC cis rs9457247 0.566 rs10946207 chr6:167456036 C/T cg07741184 chr6:167504864 NA 0.37 6.3 0.36 1.24e-9 Crohn's disease; CESC cis rs9457247 0.935 rs1044059 chr6:167369897 C/A cg23791538 chr6:167370224 RNASET2 0.59 8.29 0.45 5.92e-15 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14259716 chr8:145623015 CPSF1 -0.53 -6.24 -0.36 1.7e-9 Gut microbiome composition (summer); CESC cis rs933688 1.000 rs7715402 chr5:90679504 T/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.16 16.64 0.71 4.87e-43 Smoking behavior; CESC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg12463550 chr7:65579703 CRCP 0.49 6.11 0.35 3.61e-9 Aortic root size; CESC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg17949981 chr6:28129498 ZNF389 0.42 5.23 0.31 3.39e-7 Depression; CESC cis rs6582630 0.537 rs6582500 chr12:38534206 G/A cg26384229 chr12:38710491 ALG10B 0.74 11.16 0.57 6e-24 Drug-induced liver injury (flucloxacillin); CESC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg27125505 chr17:43679177 LOC644172 -0.47 -6.4 -0.37 6.98e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs79976124 0.879 rs12214239 chr6:66636059 A/G cg07460842 chr6:66804631 NA 0.72 8.31 0.45 5.13e-15 Type 2 diabetes; CESC cis rs12220238 0.554 rs11001029 chr10:76154777 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.56 5.16 0.3 4.9e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg19539972 chr4:7069911 GRPEL1 0.71 7.39 0.41 1.89e-12 Monocyte percentage of white cells; CESC cis rs1395 0.778 rs4665960 chr2:27467598 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.45 5.84 0.34 1.53e-8 Blood metabolite levels; CESC cis rs8092503 1.000 rs12970682 chr18:52481635 G/A cg12377874 chr18:52495404 RAB27B 0.38 6.2 0.36 2.13e-9 Childhood body mass index; CESC cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.33 -5.05 -0.3 8.33e-7 Platelet count; CESC cis rs8031584 0.651 rs28664821 chr15:31172323 G/A cg08704250 chr15:31115839 NA 0.74 10.56 0.54 5.53e-22 Huntington's disease progression; CESC cis rs11690935 0.589 rs6729945 chr2:172864695 C/G cg13550731 chr2:172543902 DYNC1I2 0.48 6.63 0.38 1.83e-10 Schizophrenia; CESC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg17372223 chr3:52568218 NT5DC2 0.44 6.64 0.38 1.8e-10 Bipolar disorder; CESC cis rs9596863 1.000 rs9568943 chr13:54423065 G/T ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 -0.61 -6.87 -0.39 4.55e-11 IgG glycosylation; CESC cis rs12464483 0.591 rs4952170 chr2:30885429 G/A cg07150166 chr2:30669952 LCLAT1 0.52 5.03 0.3 8.86e-7 Pre-treatment pain in head and neck squamous cell carcinoma; CESC trans rs875971 0.638 rs3898855 chr7:66036398 G/C cg26939375 chr7:64535504 NA -0.64 -8.7 -0.47 3.62e-16 Aortic root size; CESC cis rs1559088 0.948 rs12610266 chr19:33581237 C/G cg27124370 chr19:33622961 WDR88 -0.48 -6.37 -0.36 8.14e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2718058 0.613 rs2718037 chr7:37777846 G/C cg15028436 chr7:37888078 TXNDC3 0.44 5.99 0.35 6.68e-9 Alzheimer's disease (late onset); CESC cis rs9612 1.000 rs346534 chr19:44250831 A/G cg08581076 chr19:44259116 C19orf61 0.5 5.9 0.34 1.1e-8 Exhaled nitric oxide output; CESC cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg08564027 chr20:61660810 NA 0.9 15.14 0.68 9.71e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs7520050 0.966 rs12409773 chr1:46358831 A/G cg03146154 chr1:46216737 IPP -0.45 -5.71 -0.33 2.99e-8 Red blood cell count;Reticulocyte count; CESC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg27121462 chr16:89883253 FANCA 0.76 10.69 0.55 2.04e-22 Vitiligo; CESC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg05457628 chr5:178986728 RUFY1 0.43 6.07 0.35 4.45e-9 Lung cancer; CESC cis rs9309473 0.519 rs2178154 chr2:73661738 C/T cg20560298 chr2:73613845 ALMS1 0.49 7.01 0.4 1.92e-11 Metabolite levels; CESC cis rs7605827 0.930 rs11681344 chr2:15711885 C/A cg19274914 chr2:15703543 NA 0.3 5.23 0.31 3.38e-7 Educational attainment (years of education); CESC cis rs1050631 0.592 rs948417 chr18:33711274 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.52 7.14 0.4 9.15e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg00677455 chr12:58241039 CTDSP2 0.51 6.46 0.37 5.06e-10 Multiple sclerosis; CESC cis rs9291683 0.552 rs11736410 chr4:10017241 G/A cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 9.06e-37 Bone mineral density; CESC cis rs6088580 0.634 rs6059880 chr20:33088669 G/A cg06115741 chr20:33292138 TP53INP2 0.46 5.82 0.34 1.68e-8 Glomerular filtration rate (creatinine); CESC cis rs2197308 0.765 rs11182481 chr12:37926019 T/C cg13010199 chr12:38710504 ALG10B 0.49 6.14 0.35 3.06e-9 Morning vs. evening chronotype; CESC cis rs3008870 0.920 rs3008860 chr1:67391003 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.03 0.68 2.49e-37 Lymphocyte percentage of white cells; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg12477297 chr1:150336859 RPRD2 -0.55 -6.17 -0.35 2.57e-9 Subjective well-being; CESC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.9 -0.52 7.25e-20 Developmental language disorder (linguistic errors); CESC cis rs11155671 0.530 rs7742993 chr6:150205095 G/A cg09699651 chr6:150184138 LRP11 0.55 7.62 0.42 4.45e-13 Testicular germ cell tumor; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg24881159 chr15:31284219 MTMR10 0.49 6.28 0.36 1.39e-9 Systemic lupus erythematosus; CESC cis rs763121 0.853 rs9610986 chr22:39025277 T/C cg14440974 chr22:39074834 NA -0.41 -5.48 -0.32 9.71e-8 Menopause (age at onset); CESC cis rs3862260 0.509 rs2281493 chr1:120162787 T/C cg11530693 chr1:120165357 ZNF697 0.69 10.68 0.55 2.17e-22 Systemic lupus erythematosus; CESC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg07701084 chr6:150067640 NUP43 0.44 6.03 0.35 5.38e-9 Lung cancer; CESC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg05332525 chr7:65337924 VKORC1L1 -0.49 -6.05 -0.35 5.03e-9 Aortic root size; CESC cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg26597838 chr10:835615 NA 1.18 11.49 0.58 4.57e-25 Eosinophil percentage of granulocytes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05611218 chr5:43121586 ZNF131 -0.56 -7.17 -0.4 7.5e-12 Ulcerative colitis; CESC cis rs7264396 0.635 rs6088971 chr20:34535373 A/G cg17201900 chr20:34330562 RBM39 0.49 5.11 0.3 6.14e-7 Total cholesterol levels; CESC cis rs1784581 0.894 rs1784594 chr6:162382734 A/G cg17173639 chr6:162384350 PARK2 -0.82 -13.71 -0.64 1.1e-32 Itch intensity from mosquito bite; CESC cis rs4728302 0.869 rs10156088 chr7:133592544 G/A cg10665199 chr7:133106180 EXOC4 0.38 5.33 0.31 2.05e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs6691722 0.503 rs1142057 chr1:24706292 C/T cg02336364 chr1:24764700 NIPAL3 -0.32 -6.79 -0.38 7.45e-11 Response to interferon beta in multiple sclerosis; CESC cis rs116095464 0.558 rs10057492 chr5:239503 T/C cg20965017 chr5:231967 SDHA -0.47 -5.3 -0.31 2.49e-7 Breast cancer; CESC cis rs1577917 0.959 rs12201739 chr6:86720739 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.37 -0.36 8.3e-10 Response to antipsychotic treatment; CESC cis rs1538970 0.816 rs11211123 chr1:45957609 G/A cg03146154 chr1:46216737 IPP 0.49 5.57 0.32 6.31e-8 Platelet count; CESC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg24733560 chr20:60626293 TAF4 0.49 7.13 0.4 9.83e-12 Body mass index; CESC cis rs1270639 0.778 rs1638021 chr7:157438037 A/G cg13357408 chr7:157437802 PTPRN2 0.56 6.42 0.37 6.42e-10 Colorectal cancer; CESC cis rs11792861 0.926 rs11787878 chr9:111866749 C/T cg05043794 chr9:111880884 C9orf5 -0.42 -6.93 -0.39 3.22e-11 Menarche (age at onset); CESC cis rs2652822 0.901 rs4775622 chr15:63408179 A/C cg02713581 chr15:63449717 RPS27L 0.53 6.88 0.39 4.24e-11 Metabolic traits; CESC trans rs7618501 0.602 rs9311446 chr3:50092226 G/A cg21659725 chr3:3221576 CRBN -0.53 -7.42 -0.41 1.59e-12 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02599068 chr2:25195213 DNAJC27 0.45 6.13 0.35 3.16e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9815354 0.812 rs73073229 chr3:42007850 T/C cg03022575 chr3:42003672 ULK4 0.69 6.24 0.36 1.72e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg21694044 chr22:41215540 SLC25A17 -0.47 -6.06 -0.35 4.75e-9 Recombination measurement; CESC cis rs4555082 0.957 rs3825762 chr14:105752404 T/C cg06808227 chr14:105710500 BRF1 -0.53 -6.54 -0.37 3.14e-10 Mean platelet volume;Platelet distribution width; CESC cis rs660498 0.507 rs765700 chr10:27734885 G/A cg08398567 chr10:27609333 NA 0.39 5.36 0.31 1.79e-7 Asthma (childhood onset); CESC cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg18252515 chr7:66147081 NA -1.25 -12.55 -0.61 1.18e-28 Diabetic kidney disease; CESC cis rs6831352 0.879 rs2602888 chr4:100041706 C/T cg13256891 chr4:100009986 ADH5 0.74 7.89 0.44 7.94e-14 Alcohol dependence; CESC cis rs72781680 0.716 rs72788206 chr2:24084989 T/C cg08917208 chr2:24149416 ATAD2B 0.58 5.81 0.34 1.82e-8 Lymphocyte counts; CESC cis rs6665290 0.669 rs3738725 chr1:227174210 T/C cg10327440 chr1:227177885 CDC42BPA -1.14 -25.39 -0.84 6.16e-73 Myeloid white cell count; CESC cis rs208520 0.909 rs58958359 chr6:67021381 A/C cg07460842 chr6:66804631 NA 0.84 8.13 0.45 1.67e-14 Exhaled nitric oxide output; CESC cis rs75804782 0.690 rs56198112 chr2:239348887 A/G cg18131467 chr2:239335373 ASB1 -0.66 -5.83 -0.34 1.58e-8 Morning vs. evening chronotype;Chronotype; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17411103 chr17:65241599 HELZ 0.48 6.14 0.35 3.04e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9457247 1.000 rs429083 chr6:167383972 T/C cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.76e-8 Crohn's disease; CESC cis rs722599 0.748 rs3742783 chr14:75377008 C/T cg11812906 chr14:75593930 NEK9 -0.47 -5.63 -0.33 4.7e-8 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05703344 chr12:111051745 TCTN1 -0.57 -6.67 -0.38 1.51e-10 Gut microbiome composition (summer); CESC cis rs1348850 0.574 rs11889488 chr2:178426793 A/G cg23306229 chr2:178417860 TTC30B -0.7 -6.03 -0.35 5.46e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7216064 1.000 rs9912770 chr17:65868233 C/T cg12091567 chr17:66097778 LOC651250 -0.8 -9.03 -0.49 3.62e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2806561 0.796 rs1738467 chr1:23506521 C/T cg12483005 chr1:23474871 LUZP1 0.39 6.15 0.35 2.86e-9 Height; CESC cis rs712039 0.652 rs853224 chr17:35791328 A/T cg16670864 chr17:35848621 DUSP14 0.44 5.38 0.31 1.63e-7 Tuberculosis; CESC cis rs1665050 0.534 rs12911441 chr15:59236540 T/A cg05156742 chr15:59063176 FAM63B 0.5 6.42 0.37 6.18e-10 Atopic dermatitis; CESC cis rs7772486 0.875 rs2814872 chr6:146310234 T/C cg23711669 chr6:146136114 FBXO30 0.9 13.1 0.63 1.45e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs2066819 1.000 rs773664 chr12:56702176 C/T cg26316697 chr12:56727976 PAN2 -0.69 -6.58 -0.37 2.52e-10 Psoriasis vulgaris; CESC cis rs6964587 1.000 rs6950470 chr7:91680641 G/A cg17063962 chr7:91808500 NA 0.56 7.79 0.43 1.53e-13 Breast cancer; CESC cis rs9815354 0.812 rs74947509 chr3:42006323 T/C cg03022575 chr3:42003672 ULK4 0.67 6.27 0.36 1.43e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs916888 0.821 rs199513 chr17:44856932 A/G cg01570182 chr17:44337453 NA -0.84 -10.02 -0.52 3.09e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs113835537 0.529 rs11227509 chr11:66281194 T/C cg24851651 chr11:66362959 CCS 0.45 5.55 0.32 6.92e-8 Airway imaging phenotypes; CESC cis rs9287719 0.781 rs6732671 chr2:10759149 T/G cg02196655 chr2:10830764 NOL10 -0.36 -5.59 -0.32 5.58e-8 Prostate cancer; CESC cis rs9486719 1.000 rs2263192 chr6:96873037 C/G cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs2749592 0.725 rs9417245 chr10:37826322 C/T cg25427524 chr10:38739819 LOC399744 0.41 5.09 0.3 6.81e-7 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01187952 chr3:63850081 THOC7;ATXN7 0.65 8.15 0.45 1.42e-14 Gut microbiome composition (summer); CESC cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg22535103 chr8:58192502 C8orf71 -0.92 -11.42 -0.57 7.99e-25 Developmental language disorder (linguistic errors); CESC cis rs796364 0.616 rs769955 chr2:200692595 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.55 5.44 0.32 1.24e-7 Schizophrenia; CESC cis rs77972916 0.536 rs59362315 chr2:43594931 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -5.39 -0.31 1.57e-7 Granulocyte percentage of myeloid white cells; CESC cis rs9393777 0.513 rs13210025 chr6:26654817 A/C cg12826209 chr6:26865740 GUSBL1 0.73 7.92 0.44 6.48e-14 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02153299 chr16:30968484 SETD1A -0.47 -6.41 -0.37 6.48e-10 Fibrinogen levels; CESC cis rs3749237 0.595 rs1464567 chr3:49459252 C/G cg07636037 chr3:49044803 WDR6 -0.6 -8.62 -0.47 6.31e-16 Resting heart rate; CESC cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg10570241 chr7:158785291 NA 0.31 5.31 0.31 2.32e-7 Facial morphology (factor 20); CESC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg26354017 chr1:205819088 PM20D1 0.85 13.22 0.63 5.7e-31 Menarche (age at onset); CESC cis rs1957429 0.808 rs8009510 chr14:65351338 T/G cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC cis rs6460942 0.597 rs12699381 chr7:12527026 G/A cg10578991 chr7:12443926 VWDE -0.49 -5.08 -0.3 7.1e-7 Coronary artery disease; CESC cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.15 0.3 5.01e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.19 0.36 2.25e-9 Bipolar disorder; CESC cis rs977987 0.806 rs34996006 chr16:75479434 A/G cg03315344 chr16:75512273 CHST6 0.43 6.15 0.35 2.85e-9 Dupuytren's disease; CESC cis rs11098499 0.908 rs12504149 chr4:120318577 G/A cg09307838 chr4:120376055 NA 0.92 12.53 0.61 1.29e-28 Corneal astigmatism; CESC cis rs1448094 0.791 rs61929395 chr12:86331584 A/T cg02569458 chr12:86230093 RASSF9 0.45 6.43 0.37 5.79e-10 Major depressive disorder; CESC cis rs7131987 0.903 rs10843373 chr12:29420608 A/T cg09582351 chr12:29534625 ERGIC2 -0.33 -5.58 -0.32 6.03e-8 QT interval; CESC cis rs765787 0.530 rs4775832 chr15:45534828 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs854765 0.547 rs4925135 chr17:17952868 T/C cg16928487 chr17:17741425 SREBF1 0.55 9.13 0.49 1.86e-17 Total body bone mineral density; CESC cis rs7336332 0.598 rs1885988 chr13:28010262 C/T cg22138327 chr13:27999177 GTF3A -0.61 -5.93 -0.34 9.33e-9 Weight; CESC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2455799 0.634 rs11128764 chr3:15902836 G/C cg16303742 chr3:15540471 COLQ -0.38 -5.93 -0.34 9.55e-9 Mean platelet volume; CESC cis rs1707322 0.721 rs10789471 chr1:46215619 G/A cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07899956 chr17:74261249 FAM100B -0.42 -6.14 -0.35 3.08e-9 Fibrinogen levels; CESC cis rs1538970 0.962 rs3219489 chr1:45797505 C/G cg05343316 chr1:45956843 TESK2 0.85 10.73 0.55 1.58e-22 Platelet count; CESC cis rs1372520 0.577 rs2737028 chr4:90717016 A/G cg15133208 chr4:90757351 SNCA -0.43 -5.74 -0.33 2.63e-8 Neuroticism; CESC cis rs28830936 0.625 rs8038764 chr15:41907905 A/C cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 0.33 5.13 0.3 5.61e-7 Diastolic blood pressure; CESC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg03351412 chr1:154909251 PMVK 0.69 9.21 0.49 1.02e-17 Prostate cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27140474 chr11:82868555 PCF11 -0.48 -6.86 -0.39 4.89e-11 Gut microbiota (bacterial taxa); CESC cis rs2425143 1.000 rs7273174 chr20:34350306 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.67 5.85 0.34 1.42e-8 Blood protein levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06633615 chr10:131592944 NA -0.43 -6.09 -0.35 3.92e-9 Systemic lupus erythematosus; CESC cis rs1055129 0.537 rs1135640 chr17:73949540 C/G cg02678768 chr17:74002944 EVPL -0.4 -5.49 -0.32 9.61e-8 White matter hyperintensity burden; CESC cis rs12200560 0.505 rs60879781 chr6:97075466 A/T cg06623918 chr6:96969491 KIAA0776 0.5 6.49 0.37 4.13e-10 Coronary heart disease; CESC trans rs561341 1.000 rs546519 chr17:30297682 T/G cg20587970 chr11:113659929 NA -1.12 -14.24 -0.66 1.49e-34 Hip circumference adjusted for BMI; CESC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg14773178 chr5:1868261 NA 0.29 5.09 0.3 6.89e-7 Cardiovascular disease risk factors; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg19732566 chr8:145911660 NA -0.37 -6.02 -0.35 5.76e-9 Height; CESC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg18876405 chr7:65276391 NA -0.56 -7.56 -0.42 6.66e-13 Aortic root size; CESC cis rs10927875 0.722 rs1763605 chr1:16338925 T/G cg21214613 chr1:16344536 HSPB7 0.37 5.42 0.32 1.31e-7 Dilated cardiomyopathy; CESC cis rs453301 0.624 rs2288671 chr8:8860894 T/C cg06636001 chr8:8085503 FLJ10661 0.43 5.51 0.32 8.57e-8 Joint mobility (Beighton score); CESC cis rs854765 0.505 rs2955358 chr17:17946623 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.57 -8.11 -0.45 1.84e-14 Total body bone mineral density; CESC cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.36 0.31 1.79e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg10578991 chr7:12443926 VWDE -0.5 -5.34 -0.31 2.03e-7 Coronary artery disease; CESC cis rs950776 0.647 rs495956 chr15:78869930 C/T cg06917634 chr15:78832804 PSMA4 -0.5 -6.19 -0.36 2.26e-9 Sudden cardiac arrest; CESC cis rs12586317 0.547 rs112138868 chr14:35444385 C/T cg05294307 chr14:35346193 BAZ1A -0.49 -5.37 -0.31 1.75e-7 Psoriasis; CESC cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg22875332 chr1:76189707 ACADM 0.59 5.66 0.33 3.89e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7786808 0.712 rs2335167 chr7:158213948 A/C cg01191920 chr7:158217561 PTPRN2 -0.36 -6.07 -0.35 4.41e-9 Obesity-related traits; CESC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -6.75 -0.38 9.55e-11 Bipolar disorder; CESC trans rs2755237 0.519 rs11616662 chr13:41119466 A/G cg16029875 chr1:204320179 PLEKHA6 0.57 6.05 0.35 4.91e-9 Central corneal thickness; CESC cis rs9291683 0.588 rs12647117 chr4:10022059 T/C cg00071950 chr4:10020882 SLC2A9 0.9 17.26 0.73 2.98e-45 Bone mineral density; CESC cis rs7772486 0.790 rs3924498 chr6:146233338 A/T cg05347473 chr6:146136440 FBXO30 -0.57 -7.31 -0.41 3.07e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2456568 0.867 rs7935801 chr11:93658000 G/A cg26875233 chr11:93583750 C11orf90 -0.32 -5.56 -0.32 6.54e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg23978390 chr7:1156363 C7orf50 0.64 6.33 0.36 1.03e-9 Bronchopulmonary dysplasia; CESC cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg00074818 chr8:8560427 CLDN23 0.38 5.41 0.32 1.39e-7 Obesity-related traits; CESC trans rs1814175 0.519 rs3913237 chr11:49551828 G/A cg15704280 chr7:45808275 SEPT13 0.82 9.9 0.52 7.22e-20 Height; CESC cis rs11577318 0.853 rs11803933 chr1:26629465 G/C cg19743891 chr1:26644573 UBXN11;CD52 -0.28 -5.11 -0.3 6.05e-7 Granulocyte percentage of myeloid white cells; CESC trans rs60380162 0.963 rs4111582 chr1:87736382 G/A cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.04 -0.35 5.32e-9 Loneliness (linear analysis); CESC cis rs11871801 1.000 rs6503703 chr17:40592207 A/T cg21433558 chr17:40837037 CNTNAP1 0.45 5.06 0.3 7.79e-7 Crohn's disease; CESC cis rs78456975 1.000 rs13413096 chr2:1553588 G/A cg26248373 chr2:1572462 NA -0.57 -5.31 -0.31 2.29e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs477692 0.905 rs508360 chr10:131424969 A/G cg05714579 chr10:131428358 MGMT 0.58 8.4 0.46 2.66e-15 Response to temozolomide; CESC cis rs208520 0.690 rs1351867 chr6:66760995 A/G cg07460842 chr6:66804631 NA 0.96 12.67 0.61 4.52e-29 Exhaled nitric oxide output; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg07822143 chr4:146019674 ABCE1;ANAPC10 -0.4 -6.16 -0.35 2.7e-9 Vertical cup-disc ratio; CESC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg12463550 chr7:65579703 CRCP -0.46 -5.81 -0.34 1.76e-8 Aortic root size; CESC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.84 0.34 1.51e-8 Bipolar disorder; CESC cis rs854765 0.583 rs11650890 chr17:17790882 C/T cg04398451 chr17:18023971 MYO15A 0.64 8.99 0.48 4.76e-17 Total body bone mineral density; CESC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg24675658 chr1:53192096 ZYG11B 0.77 11.82 0.59 3.51e-26 Monocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24397552 chr15:40226086 EIF2AK4 0.44 6.21 0.36 2.06e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11421459 chr7:91763989 CYP51A1 -0.57 -6.33 -0.36 1.04e-9 Gut microbiome composition (summer); CESC cis rs9420 0.961 rs499188 chr11:57434122 C/A cg23127183 chr11:57508653 C11orf31 -0.43 -5.05 -0.3 8.37e-7 Schizophrenia; CESC cis rs7208859 0.623 rs56378576 chr17:29010120 C/T cg13385521 chr17:29058706 SUZ12P 0.72 5.63 0.33 4.63e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9486715 0.867 rs9480700 chr6:96965056 A/G cg18709589 chr6:96969512 KIAA0776 0.47 6.57 0.37 2.6200000000000003e-10 Headache; CESC cis rs7210086 0.808 rs6501558 chr17:70639488 T/C cg04206342 chr17:70636940 NA -0.33 -6.09 -0.35 3.92e-9 Ulcerative colitis; CESC cis rs2842992 0.830 rs1535475 chr6:160148935 T/C cg11366901 chr6:160182831 ACAT2 0.77 9.96 0.52 4.68e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs9814567 0.752 rs1534030 chr3:134330083 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.09 -0.3 6.84e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg18765753 chr7:1198926 ZFAND2A -0.58 -8.93 -0.48 7.49e-17 Longevity;Endometriosis; CESC cis rs9863 0.828 rs34114498 chr12:124480373 G/C cg17562584 chr12:124393655 DNAH10 0.32 5.5 0.32 8.94e-8 White blood cell count; CESC cis rs7520050 0.933 rs12045165 chr1:46256022 C/A cg06784218 chr1:46089804 CCDC17 -0.29 -5.15 -0.3 5.07e-7 Red blood cell count;Reticulocyte count; CESC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg12419862 chr22:24373484 LOC391322 0.68 9.49 0.5 1.42e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9902453 0.900 rs9910970 chr17:28478329 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.35 0.46 3.91e-15 Coffee consumption (cups per day); CESC cis rs3820068 0.655 rs72645826 chr1:15889741 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.81 0.34 1.8e-8 Systolic blood pressure; CESC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg24549020 chr5:56110836 MAP3K1 0.68 7.64 0.43 3.9e-13 Initial pursuit acceleration; CESC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs1003719 0.680 rs2835629 chr21:38521660 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.03 -0.44 3.23e-14 Eye color traits; CESC cis rs7809950 0.954 rs12673675 chr7:107113220 T/C cg23024343 chr7:107201750 COG5 -0.43 -6.11 -0.35 3.58e-9 Coronary artery disease; CESC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg06634786 chr22:41940651 POLR3H -0.72 -7.55 -0.42 7.14e-13 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12538597 chr11:85906334 NA -0.69 -8.49 -0.46 1.51e-15 Gut microbiome composition (summer); CESC cis rs1797081 1.000 rs1797081 chr10:16874565 A/G cg23933602 chr10:16859644 RSU1 1.12 24.3 0.83 2.17e-69 Platelet distribution width; CESC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.64 0.38 1.78e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6963495 0.556 rs818474 chr7:105155243 A/T cg19920283 chr7:105172520 RINT1 0.54 6.28 0.36 1.41e-9 Bipolar disorder (body mass index interaction); CESC cis rs79349575 0.721 rs3744608 chr17:46993233 C/G cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12275661 chr10:33247232 ITGB1 0.68 7.68 0.43 3.06e-13 Gut microbiome composition (summer); CESC cis rs7762018 0.660 rs78181018 chr6:170096652 A/C cg19338460 chr6:170058176 WDR27 -1.06 -8.47 -0.46 1.73e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs965469 1.000 rs6037556 chr20:3317890 G/C cg25506879 chr20:3388711 C20orf194 -0.53 -5.81 -0.34 1.78e-8 IFN-related cytopenia; CESC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6e-10 Life satisfaction; CESC cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg06627628 chr2:24431161 ITSN2 -0.66 -6.22 -0.36 1.98e-9 Lymphocyte counts; CESC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg14664628 chr15:75095509 CSK -0.53 -7.01 -0.4 1.96e-11 Breast cancer; CESC cis rs11630290 0.649 rs1036910 chr15:64157015 T/C cg12036633 chr15:63758958 NA 0.44 5.28 0.31 2.74e-7 Iris characteristics; CESC cis rs7100689 0.646 rs1934696 chr10:82124966 T/C cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs9902453 0.904 rs12936302 chr17:28349476 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -9.33 -0.5 4.29e-18 Coffee consumption (cups per day); CESC cis rs35146811 0.622 rs6946204 chr7:99589125 T/C cg22531904 chr7:99595276 NA -0.39 -5.15 -0.3 5.12e-7 Coronary artery disease; CESC cis rs6026584 1.000 rs15754 chr20:57469227 C/G cg11480267 chr20:57463503 GNAS 0.47 5.69 0.33 3.44e-8 Renal function-related traits (BUN); CESC cis rs637571 0.558 rs10896064 chr11:65641033 G/C cg26695010 chr11:65641043 EFEMP2 0.63 8.0 0.44 3.86e-14 Eosinophil percentage of white cells; CESC cis rs8114671 0.527 rs2253484 chr20:33405263 A/T cg08999081 chr20:33150536 PIGU -0.38 -5.42 -0.32 1.32e-7 Height; CESC cis rs863345 0.967 rs7517254 chr1:158469882 A/G cg12129480 chr1:158549410 OR10X1 -0.31 -6.19 -0.36 2.34e-9 Pneumococcal bacteremia; CESC cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg03433033 chr1:76189801 ACADM 0.71 9.69 0.51 3.31e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7662987 0.517 rs2851263 chr4:100030354 A/G cg12011299 chr4:100065546 ADH4 0.6 6.52 0.37 3.48e-10 Smoking initiation; CESC cis rs6121246 0.567 rs6058189 chr20:30192389 A/G cg13852791 chr20:30311386 BCL2L1 0.67 6.71 0.38 1.2e-10 Mean corpuscular hemoglobin; CESC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg04944784 chr2:26401820 FAM59B 0.67 7.58 0.42 5.95e-13 Gut microbiome composition (summer); CESC trans rs73568641 0.583 rs73572625 chr6:154089464 T/C cg08374472 chr16:87445639 ZCCHC14 -0.46 -6.15 -0.35 2.82e-9 Methadone dose in opioid dependence; CESC trans rs709082 0.573 rs709088 chr3:191461155 C/T cg25305879 chr2:106814630 NA 0.41 6.45 0.37 5.29e-10 Colonoscopy-negative controls vs population controls; CESC cis rs7904368 0.806 rs6602161 chr10:16862280 A/G cg23933602 chr10:16859644 RSU1 0.64 6.02 0.35 5.67e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC trans rs561341 0.824 rs1978115 chr17:30220776 A/C cg20587970 chr11:113659929 NA -1.03 -12.71 -0.62 3.33e-29 Hip circumference adjusted for BMI; CESC cis rs9517313 0.615 rs4772079 chr13:99090837 C/G cg07423050 chr13:99094983 FARP1 -0.32 -5.61 -0.33 5.12e-8 Neuroticism; CESC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg17372223 chr3:52568218 NT5DC2 0.44 6.54 0.37 3.13e-10 Bipolar disorder; CESC cis rs4919694 1.000 rs12241091 chr10:104808997 G/A cg04362960 chr10:104952993 NT5C2 0.79 7.08 0.4 1.27e-11 Arsenic metabolism; CESC cis rs6499129 0.558 rs28711261 chr16:67617186 A/G cg26727032 chr16:67993705 SLC12A4 -0.57 -6.12 -0.35 3.41e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs611744 0.647 rs10106246 chr8:109268710 T/C cg21045802 chr8:109455806 TTC35 0.48 5.99 0.35 6.98e-9 Dupuytren's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00252696 chr1:31769601 ZCCHC17;SNRNP40 -0.41 -6.03 -0.35 5.53e-9 Fibrinogen levels; CESC trans rs9858542 0.953 rs11715915 chr3:49455330 A/G cg21659725 chr3:3221576 CRBN 0.58 6.65 0.38 1.66e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs8141529 0.509 rs5762864 chr22:29253364 T/C cg02153584 chr22:29168773 CCDC117 0.6 8.06 0.44 2.66e-14 Lymphocyte counts; CESC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg11987759 chr7:65425863 GUSB -0.46 -6.09 -0.35 4.02e-9 Aortic root size; CESC cis rs6076065 0.748 rs6137933 chr20:23383103 A/T cg11657817 chr20:23433608 CST11 0.4 6.1 0.35 3.7e-9 Facial morphology (factor 15, philtrum width); CESC cis rs6540556 0.682 rs11119332 chr1:209892960 C/T cg05527609 chr1:210001259 C1orf107 -0.66 -7.34 -0.41 2.56e-12 Red blood cell count; CESC cis rs11190604 1.000 rs2495743 chr10:102329739 G/C cg07080220 chr10:102295463 HIF1AN 0.64 5.85 0.34 1.46e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs10504229 0.636 rs77691549 chr8:58055126 G/T cg21724239 chr8:58056113 NA 0.53 5.04 0.3 8.64e-7 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg04025307 chr7:1156635 C7orf50 0.41 6.61 0.38 2.11e-10 Longevity;Endometriosis; CESC cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg03676636 chr4:99064102 C4orf37 -0.34 -5.23 -0.31 3.46e-7 Colonoscopy-negative controls vs population controls; CESC trans rs2797160 0.904 rs1418637 chr6:125992553 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.49 -6.67 -0.38 1.48e-10 Endometrial cancer; CESC cis rs4474465 1.000 rs7933612 chr11:78209366 G/T cg02023728 chr11:77925099 USP35 -0.38 -5.31 -0.31 2.35e-7 Alzheimer's disease (survival time); CESC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg21770322 chr7:97807741 LMTK2 0.57 8.78 0.47 2.12e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs11792861 0.816 rs7027263 chr9:111699569 G/A cg05043794 chr9:111880884 C9orf5 -0.39 -6.41 -0.37 6.44e-10 Menarche (age at onset); CESC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg06505273 chr16:24850292 NA -0.52 -5.93 -0.34 9.48e-9 Intelligence (multi-trait analysis); CESC cis rs4253772 0.513 rs9615345 chr22:46713631 C/T cg07012999 chr22:46692446 CN5H6.4;GTSE1 0.55 5.6 0.33 5.26e-8 LDL cholesterol;Cholesterol, total; CESC cis rs8060686 0.516 rs255052 chr16:68024995 C/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.43 -0.37 5.99e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg18099408 chr3:52552593 STAB1 -0.36 -6.1 -0.35 3.74e-9 Electroencephalogram traits; CESC cis rs2274273 0.624 rs67795323 chr14:55797833 G/A cg04306507 chr14:55594613 LGALS3 0.29 5.11 0.3 6.15e-7 Protein biomarker; CESC cis rs10129255 0.500 rs8004923 chr14:107194164 A/G cg23076370 chr14:107095027 NA -0.64 -9.33 -0.5 4.36e-18 Kawasaki disease; CESC cis rs7202877 0.706 rs11149812 chr16:75323645 T/C cg04384234 chr16:75411784 CFDP1 -0.45 -5.19 -0.3 4.24e-7 Type 2 diabetes;Type 1 diabetes; CESC cis rs2075371 0.863 rs34231360 chr7:133944988 A/C cg20476274 chr7:133979776 SLC35B4 0.63 9.07 0.49 2.72e-17 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07319014 chr16:89777268 C16orf7 -0.59 -6.73 -0.38 1.05e-10 Gut microbiome composition (summer); CESC cis rs1003719 0.688 rs2835660 chr21:38568882 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.58e-15 Eye color traits; CESC cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg04317338 chr11:64019027 PLCB3 0.7 5.96 0.34 8.22e-9 Mean platelet volume; CESC cis rs8044868 0.530 rs2287999 chr16:72059149 A/G cg01557791 chr16:72042693 DHODH -0.46 -6.36 -0.36 8.8e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs11252926 0.565 rs60553947 chr10:474284 T/C cg03684893 chr10:554711 DIP2C 0.37 5.42 0.32 1.35e-7 Psychosis in Alzheimer's disease; CESC cis rs9287719 0.967 rs6709466 chr2:10748257 T/C cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs9322193 0.607 rs9322229 chr6:150230085 A/G cg01145232 chr6:150245071 RAET1G 0.45 5.93 0.34 9.65e-9 Lung cancer; CESC cis rs11048434 0.636 rs11047953 chr12:9064923 A/C cg23795048 chr12:9217529 LOC144571 0.36 5.68 0.33 3.46e-8 Sjögren's syndrome; CESC cis rs6693567 0.565 rs578353 chr1:150287884 C/G cg09579323 chr1:150459698 TARS2 0.44 5.93 0.34 9.45e-9 Migraine; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19455322 chr3:46735335 ALS2CL -0.43 -6.65 -0.38 1.67e-10 Gambling; CESC cis rs2236918 1.000 rs1776137 chr1:242027045 A/G cg17736920 chr1:242011382 EXO1 0.72 9.16 0.49 1.5e-17 Menopause (age at onset); CESC cis rs12142240 0.698 rs1475390 chr1:46816340 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs6942756 0.955 rs9641849 chr7:128899238 C/T cg02491457 chr7:128862824 NA -0.7 -9.93 -0.52 5.71e-20 White matter hyperintensity burden; CESC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg05313129 chr8:58192883 C8orf71 -0.54 -6.23 -0.36 1.82e-9 Developmental language disorder (linguistic errors); CESC cis rs8062405 1.000 rs8055138 chr16:28891465 C/T cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4654899 1.000 rs7554770 chr1:21481361 A/T cg05370193 chr1:21551575 ECE1 0.41 6.22 0.36 1.96e-9 Superior frontal gyrus grey matter volume; CESC cis rs3820068 0.603 rs72647138 chr1:15980929 C/T cg13390004 chr1:15929781 NA 0.36 5.69 0.33 3.37e-8 Systolic blood pressure; CESC cis rs6893300 0.961 rs3797776 chr5:179193598 C/T cg14593053 chr5:179126677 CANX -0.52 -5.77 -0.33 2.19e-8 Resting heart rate; CESC cis rs7605827 0.897 rs6431715 chr2:15717917 C/A cg19274914 chr2:15703543 NA 0.35 6.39 0.37 7.23e-10 Educational attainment (years of education); CESC cis rs16854884 0.657 rs1867609 chr3:143752916 A/G cg06585982 chr3:143692056 C3orf58 0.5 6.71 0.38 1.18e-10 Economic and political preferences (feminism/equality); CESC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.09 11.08 0.56 1.09e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3204270 0.639 rs62080213 chr17:79642531 C/T cg26965718 chr17:79658957 HGS -0.75 -5.53 -0.32 7.54e-8 Dental caries; CESC cis rs2933343 0.729 rs789224 chr3:128598231 A/C cg25356066 chr3:128598488 ACAD9 0.63 8.94 0.48 6.95e-17 IgG glycosylation; CESC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs9858542 0.953 rs1801143 chr3:49570200 C/T cg03060546 chr3:49711283 APEH -0.52 -5.99 -0.35 6.8e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs10845606 1.000 rs11055013 chr12:12829037 T/C cg04607235 chr12:12878440 APOLD1 -0.7 -7.84 -0.43 1.12e-13 Systemic lupus erythematosus; CESC cis rs2243480 1.000 rs35432774 chr7:65393019 G/C cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC cis rs72634258 0.554 rs13306061 chr1:7913445 C/T cg26816564 chr1:7831052 VAMP3 0.49 5.16 0.3 4.91e-7 Inflammatory bowel disease; CESC cis rs2991971 0.810 rs998199 chr1:45912898 A/C cg24296786 chr1:45957014 TESK2 -0.62 -8.77 -0.47 2.21e-16 High light scatter reticulocyte count; CESC cis rs6748734 1.000 rs6748734 chr2:241837452 A/G cg07537917 chr2:241836409 C2orf54 -0.25 -5.4 -0.31 1.49e-7 Urinary metabolites; CESC cis rs1801251 1.000 rs283469 chr2:233656997 G/T cg25237894 chr2:233734115 C2orf82 0.44 7.81 0.43 1.34e-13 Coronary artery disease; CESC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg19717773 chr7:2847554 GNA12 -0.56 -7.68 -0.43 3.17e-13 Height; CESC cis rs10949834 0.504 rs13238778 chr7:73567709 G/A cg07137043 chr7:73588983 EIF4H -0.63 -7.03 -0.4 1.8e-11 Verbal memory performance (residualized delayed recall change); CESC cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg17971929 chr21:40555470 PSMG1 -0.56 -7.35 -0.41 2.48e-12 Menarche (age at onset); CESC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg25072359 chr17:41440525 NA 0.48 6.46 0.37 4.98e-10 Menopause (age at onset); CESC cis rs17345786 0.906 rs58835747 chr3:101243634 T/C cg12386194 chr3:101231763 SENP7 0.6 6.53 0.37 3.28e-10 Colonoscopy-negative controls vs population controls; CESC cis rs1348850 0.526 rs6723063 chr2:178491398 C/T cg23306229 chr2:178417860 TTC30B 0.7 6.1 0.35 3.73e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7824557 0.591 rs2572452 chr8:11228254 C/T cg21775007 chr8:11205619 TDH -0.54 -8.59 -0.47 7.7e-16 Retinal vascular caliber; CESC cis rs2228479 0.764 rs35518096 chr16:89961140 C/A cg00800038 chr16:89945340 TCF25 -0.7 -6.79 -0.38 7.4e-11 Skin colour saturation; CESC cis rs734999 0.505 rs4648659 chr1:2560903 T/G cg18854424 chr1:2615690 NA -0.3 -5.83 -0.34 1.62e-8 Ulcerative colitis; CESC cis rs4629710 0.592 rs3777476 chr6:131533821 A/C cg12606694 chr6:131520996 AKAP7 0.45 5.6 0.33 5.38e-8 Multiple myeloma (IgH translocation); CESC cis rs6912958 1.000 rs2207144 chr6:88150816 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -7.57 -0.42 6.29e-13 Monocyte percentage of white cells; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg00983485 chr15:31284262 MTMR10 0.5 6.36 0.36 8.92e-10 Tetralogy of Fallot; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01930679 chr17:79514274 C17orf70 -0.52 -6.42 -0.37 6.21e-10 Gut microbiome composition (summer); CESC cis rs71403859 0.730 rs12922775 chr16:71584354 C/T cg08717414 chr16:71523259 ZNF19 -0.86 -7.78 -0.43 1.66e-13 Post bronchodilator FEV1; CESC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg07701084 chr6:150067640 NUP43 0.48 6.85 0.39 5.03e-11 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22466620 chr6:138187852 TNFAIP3 0.59 6.62 0.38 2.03e-10 Gut microbiome composition (summer); CESC cis rs4253772 0.530 rs55653327 chr22:46682976 C/T cg24881330 chr22:46731750 TRMU 0.82 6.02 0.35 5.78e-9 LDL cholesterol;Cholesterol, total; CESC cis rs8067354 0.645 rs9910518 chr17:57812067 T/C cg13753209 chr17:57696993 CLTC 0.65 7.89 0.44 7.95e-14 Hemoglobin concentration; CESC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg12412775 chr1:25698385 RHCE -0.31 -5.49 -0.32 9.57e-8 Erythrocyte sedimentation rate; CESC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg17949981 chr6:28129498 ZNF389 0.44 5.68 0.33 3.47e-8 Depression; CESC cis rs1348850 0.874 rs2166558 chr2:178373652 G/T cg22681709 chr2:178499509 PDE11A -0.41 -5.88 -0.34 1.24e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs13242816 1.000 rs13226307 chr7:116137485 A/T cg04696780 chr7:116139425 CAV2 0.57 5.22 0.31 3.61e-7 P wave duration; CESC cis rs1707322 1.000 rs6693336 chr1:46354595 C/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg19193384 chr17:30244184 NA 0.49 5.11 0.3 6.2e-7 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 9.82 0.52 1.29e-19 Prudent dietary pattern; CESC cis rs11785400 0.762 rs7007349 chr8:143722673 T/C cg24634471 chr8:143751801 JRK 0.45 5.74 0.33 2.53e-8 Schizophrenia; CESC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg23161317 chr6:28129485 ZNF389 0.38 5.24 0.31 3.26e-7 Parkinson's disease; CESC cis rs8017423 0.967 rs4900030 chr14:90689813 T/A cg14092571 chr14:90743983 NA -0.57 -8.28 -0.45 6.11e-15 Mortality in heart failure; CESC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.69 -0.33 3.38e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2777491 0.574 rs28700583 chr15:41714072 C/T cg02330683 chr15:41787940 ITPKA 0.42 5.09 0.3 6.82e-7 Ulcerative colitis; CESC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg22143856 chr6:28129313 ZNF389 0.44 5.93 0.34 9.34e-9 Depression; CESC cis rs2228479 0.850 rs11076623 chr16:89844120 G/T cg00800038 chr16:89945340 TCF25 -0.91 -7.58 -0.42 5.75e-13 Skin colour saturation; CESC trans rs561341 0.769 rs559228 chr17:30294527 T/C cg27661571 chr11:113659931 NA -0.83 -7.69 -0.43 2.82e-13 Hip circumference adjusted for BMI; CESC cis rs412050 0.947 rs239914 chr22:22317337 C/T cg17089214 chr22:22089827 YPEL1 0.66 6.14 0.35 3.02e-9 Attention deficit hyperactivity disorder; CESC cis rs3862435 0.518 rs2601166 chr15:90911179 G/A cg22089800 chr15:90895588 ZNF774 0.53 5.63 0.33 4.66e-8 Response to exercise (triglyceride level interaction); CESC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg21951975 chr1:209979733 IRF6 0.58 8.78 0.47 2.03e-16 Cleft lip with or without cleft palate; CESC cis rs9816226 0.645 rs16860471 chr3:185847441 G/T cg00760338 chr3:185826511 ETV5 -0.62 -6.61 -0.38 2.06e-10 Obesity;Body mass index; CESC cis rs3857536 0.505 rs208459 chr6:66911055 C/T cg07460842 chr6:66804631 NA -0.63 -7.73 -0.43 2.29e-13 Blood trace element (Cu levels); CESC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.78 0.38 7.7e-11 Bipolar disorder; CESC cis rs8092503 1.000 rs12964118 chr18:52495506 A/G cg12377874 chr18:52495404 RAB27B 0.37 6.14 0.35 3.02e-9 Childhood body mass index; CESC cis rs10788972 0.779 rs7516791 chr1:54551875 G/T cg25741118 chr1:54482237 LDLRAD1 -0.22 -5.25 -0.31 3.19e-7 Parkinson disease and lewy body pathology; CESC cis rs4704187 0.687 rs10805893 chr5:74507390 C/A cg03227963 chr5:74354835 NA 0.28 5.19 0.3 4.21e-7 Response to amphetamines; CESC cis rs2455799 0.613 rs11128760 chr3:15873407 A/G cg16303742 chr3:15540471 COLQ -0.38 -5.78 -0.33 2.06e-8 Mean platelet volume; CESC cis rs10088262 0.629 rs12549683 chr8:124798276 G/C cg20713898 chr8:124780851 FAM91A1 -0.67 -9.11 -0.49 2.02e-17 Pancreatic cancer; CESC cis rs3733585 0.638 rs6449155 chr4:9956547 T/G cg11266682 chr4:10021025 SLC2A9 -0.59 -11.16 -0.57 5.9e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7772486 0.681 rs9390343 chr6:146010527 A/T cg05347473 chr6:146136440 FBXO30 -0.49 -6.25 -0.36 1.65e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs561341 0.505 rs28708703 chr17:30386845 C/G cg12193833 chr17:30244370 NA -0.52 -5.12 -0.3 5.9e-7 Hip circumference adjusted for BMI; CESC cis rs9486715 0.793 rs2499777 chr6:97013814 T/C cg18709589 chr6:96969512 KIAA0776 -0.47 -6.59 -0.38 2.36e-10 Headache; CESC cis rs4812048 0.846 rs151361 chr20:57614002 A/G cg14073986 chr20:57617431 SLMO2 0.54 5.96 0.34 8.01e-9 Mean platelet volume; CESC cis rs8017423 0.900 rs11625870 chr14:90693396 C/T cg14092571 chr14:90743983 NA 0.54 7.96 0.44 5.07e-14 Mortality in heart failure; CESC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg13777783 chr17:79615861 NA 0.35 5.79 0.34 1.99e-8 Eye color traits; CESC cis rs1559088 0.600 rs58173463 chr19:33596749 C/T cg17764715 chr19:33622953 WDR88 0.58 8.2 0.45 1.02e-14 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs739401 0.572 rs384490 chr11:3078885 A/C cg25174290 chr11:3078921 CARS 0.66 9.27 0.49 6.74e-18 Longevity; CESC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg06221963 chr1:154839813 KCNN3 -0.66 -11.56 -0.58 2.63e-25 Prostate cancer; CESC cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg15017067 chr4:17643749 FAM184B 0.39 5.47 0.32 1.02e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9467711 0.606 rs9393706 chr6:26361500 G/A cg14345882 chr6:26364793 BTN3A2 0.59 6.08 0.35 4.27e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9309473 0.500 rs10865398 chr2:73741497 A/C cg20560298 chr2:73613845 ALMS1 0.47 6.77 0.38 8.28e-11 Metabolite levels; CESC cis rs3820068 0.637 rs4646080 chr1:15826627 A/T cg17385448 chr1:15911702 AGMAT 0.39 6.18 0.35 2.44e-9 Systolic blood pressure; CESC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.1 -0.3 6.4e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs11718455 1.000 rs9858826 chr3:44031412 C/T cg08738300 chr3:44038990 NA -0.43 -6.05 -0.35 4.87e-9 Coronary artery disease; CESC cis rs4808199 0.847 rs34647936 chr19:19548239 T/G cg03709012 chr19:19516395 GATAD2A 1.15 13.67 0.64 1.53e-32 Nonalcoholic fatty liver disease; CESC cis rs9733 0.744 rs12758227 chr1:150844583 C/A cg18016565 chr1:150552671 MCL1 -0.35 -5.74 -0.33 2.55e-8 Tonsillectomy; CESC cis rs1594829 0.553 rs6996531 chr8:26153455 C/A cg11498726 chr8:26250323 BNIP3L -0.4 -6.06 -0.35 4.68e-9 Height; CESC cis rs1707322 1.000 rs1768817 chr1:46514534 C/G cg03146154 chr1:46216737 IPP -0.72 -9.73 -0.51 2.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7582180 0.700 rs1437971 chr2:100986964 A/C cg07601672 chr11:27384696 CCDC34 0.59 6.07 0.35 4.44e-9 Intelligence (multi-trait analysis); CESC cis rs35306767 0.714 rs12767171 chr10:1084491 A/G cg26597838 chr10:835615 NA 0.49 5.34 0.31 1.96e-7 Eosinophil percentage of granulocytes; CESC cis rs10504229 0.636 rs114725691 chr8:58054292 C/T cg22535103 chr8:58192502 C8orf71 -0.65 -7.2 -0.4 6.27e-12 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08556938 chr17:58512855 NA -0.6 -6.48 -0.37 4.48e-10 Gut microbiome composition (summer); CESC cis rs9814567 1.000 rs9828815 chr3:134265749 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.15 -0.35 2.87e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7246657 0.765 rs10402455 chr19:37728707 G/A cg23950597 chr19:37808831 NA -0.6 -5.89 -0.34 1.16e-8 Coronary artery calcification; CESC trans rs2235573 0.527 rs139866 chr22:38354684 C/T cg19894588 chr14:64061835 NA 0.63 8.4 0.46 2.72e-15 Glioblastoma;Glioma; CESC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9660992 0.710 rs55671824 chr1:205249814 G/A cg00857998 chr1:205179979 DSTYK 0.46 5.21 0.3 3.77e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs13126513 0.519 rs12641768 chr4:100558594 C/A cg05468953 chr4:100565104 NA 0.34 5.26 0.31 2.98e-7 Metabolite levels (MHPG); CESC cis rs193541 0.593 rs154499 chr5:122219666 A/C cg19412675 chr5:122181750 SNX24 0.46 5.38 0.31 1.64e-7 Glucose homeostasis traits; CESC cis rs9308433 0.529 rs9430131 chr1:214481121 C/A cg06198575 chr1:214491504 SMYD2 0.5 6.09 0.35 3.86e-9 IgG glycosylation; CESC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg19418458 chr7:158789849 NA -0.5 -7.69 -0.43 2.81e-13 Facial morphology (factor 20); CESC cis rs2439831 0.867 rs2412778 chr15:43660982 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.87 12.96 0.62 4.52e-30 Lung cancer in ever smokers; CESC cis rs11077998 0.901 rs3794723 chr17:80529495 G/A cg10255544 chr17:80519551 FOXK2 0.55 8.73 0.47 2.83e-16 Reticulocyte fraction of red cells; CESC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg26338869 chr17:61819248 STRADA -0.67 -8.94 -0.48 6.62e-17 Prudent dietary pattern; CESC cis rs7680126 0.609 rs11723742 chr4:10111572 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -6.53 -0.37 3.39e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg19046167 chr17:80928561 B3GNTL1 0.4 5.39 0.31 1.56e-7 Breast cancer; CESC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.1 -0.3 6.45e-7 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg08470875 chr2:26401718 FAM59B 0.75 7.79 0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs10949834 0.517 rs810536 chr7:73504233 G/A cg07137043 chr7:73588983 EIF4H 0.63 7.37 0.41 2.2e-12 Verbal memory performance (residualized delayed recall change); CESC cis rs748404 0.697 rs473016 chr15:43558823 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.84 0.43 1.08e-13 Lung cancer; CESC cis rs17401966 0.898 rs12757288 chr1:10323921 T/C cg15208524 chr1:10270712 KIF1B 0.39 5.07 0.3 7.62e-7 Hepatocellular carcinoma; CESC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg10691866 chr7:65817282 TPST1 -0.32 -5.44 -0.32 1.19e-7 Aortic root size; CESC trans rs10242455 0.702 rs45448997 chr7:99041598 G/C cg09045935 chr12:6379348 NA 0.91 7.41 0.41 1.73e-12 Blood metabolite levels; CESC cis rs12476592 0.602 rs262478 chr2:63872386 T/C cg17519650 chr2:63277830 OTX1 -0.45 -5.04 -0.3 8.82e-7 Childhood ear infection; CESC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg15556689 chr8:8085844 FLJ10661 -0.43 -5.28 -0.31 2.74e-7 Mood instability; CESC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg22143856 chr6:28129313 ZNF389 0.47 5.89 0.34 1.16e-8 Depression; CESC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg08859206 chr1:53392774 SCP2 0.61 9.07 0.49 2.75e-17 Monocyte count; CESC cis rs2243480 1.000 rs462853 chr7:65558167 G/C cg12463550 chr7:65579703 CRCP 0.74 5.71 0.33 3.02e-8 Diabetic kidney disease; CESC cis rs1707322 1.000 rs10890359 chr1:46336635 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.52 0.32 8.1e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7809950 1.000 rs2066735 chr7:107188719 G/T cg23024343 chr7:107201750 COG5 -0.42 -5.76 -0.33 2.3e-8 Coronary artery disease; CESC cis rs7223966 1.000 rs7220821 chr17:61704147 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.38 -0.31 1.61e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2228479 0.702 rs2074903 chr16:89811663 T/C cg06558623 chr16:89946397 TCF25 1.19 9.55 0.51 8.99e-19 Skin colour saturation; CESC cis rs11718455 0.767 rs11708363 chr3:43966585 G/A cg08738300 chr3:44038990 NA 0.46 6.14 0.35 2.95e-9 Coronary artery disease; CESC cis rs6500395 1.000 rs1115758 chr16:48599609 T/C cg04672837 chr16:48644449 N4BP1 0.5 6.23 0.36 1.78e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6669072 0.647 rs814543 chr1:91241709 C/T cg08895590 chr1:91227319 NA 0.33 5.71 0.33 2.98e-8 Cognitive function; CESC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg18876405 chr7:65276391 NA 0.68 9.02 0.48 3.98e-17 Aortic root size; CESC cis rs67311347 1.000 rs28707772 chr3:40504666 G/A cg24209194 chr3:40518798 ZNF619 0.52 6.27 0.36 1.43e-9 Renal cell carcinoma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11450001 chr12:10365596 GABARAPL1 -0.46 -6.29 -0.36 1.31e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11295902 chr11:64546368 SF1 -0.68 -8.43 -0.46 2.25e-15 Gut microbiome composition (summer); CESC cis rs7917772 0.503 rs7896841 chr10:104294665 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.24 0.41 4.83e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg11644478 chr21:40555479 PSMG1 -0.53 -7.08 -0.4 1.28e-11 Menarche (age at onset); CESC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg08968635 chr6:28129556 ZNF389 0.43 5.76 0.33 2.31e-8 Depression; CESC cis rs12956009 0.583 rs12960952 chr18:44857476 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.52 0.37 3.49e-10 Educational attainment (years of education); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26343667 chr3:156391915 TIPARP;LOC100287227 -0.4 -6.18 -0.35 2.4e-9 Gambling; CESC cis rs2243480 1.000 rs6460274 chr7:65628484 T/A cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.25e-32 Diabetic kidney disease; CESC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg06420487 chr17:61919686 SMARCD2 -0.46 -5.62 -0.33 4.78e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23440816 chr1:223948910 CAPN2 -0.53 -6.22 -0.36 1.91e-9 Gut microbiome composition (summer); CESC cis rs6570726 0.526 rs7755237 chr6:145731852 T/C cg23711669 chr6:146136114 FBXO30 -0.62 -8.2 -0.45 1.02e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs12136530 0.744 rs66932922 chr1:19776143 G/A cg01832549 chr1:19774989 CAPZB -0.47 -6.86 -0.39 4.99e-11 Lead levels in blood; CESC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg26338869 chr17:61819248 STRADA 0.68 8.97 0.48 5.62e-17 Prudent dietary pattern; CESC cis rs12586317 0.547 rs10145723 chr14:35460954 G/A cg16230307 chr14:35515116 FAM177A1 0.99 10.61 0.55 3.76e-22 Psoriasis; CESC trans rs9467711 0.559 rs13208916 chr6:26601940 G/A cg06606381 chr12:133084897 FBRSL1 -0.74 -7.14 -0.4 8.79e-12 Autism spectrum disorder or schizophrenia; CESC cis rs9457247 0.565 rs2038580 chr6:167456490 A/T cg07741184 chr6:167504864 NA 0.36 6.21 0.36 2.05e-9 Crohn's disease; CESC cis rs7666738 0.830 rs35531558 chr4:98938217 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9309711 0.698 rs9750503 chr2:3491772 A/G cg10845886 chr2:3471009 TTC15 0.8 10.75 0.55 1.33e-22 Neurofibrillary tangles; CESC cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.59 0.32 5.78e-8 Tonsillectomy; CESC cis rs7772486 0.846 rs1474871 chr6:146406294 G/A cg23711669 chr6:146136114 FBXO30 0.76 11.08 0.56 1.11e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg13866156 chr1:1669148 SLC35E2 -0.48 -6.33 -0.36 1.04e-9 Body mass index; CESC cis rs1348850 0.668 rs13034886 chr2:178493301 G/T cg22681709 chr2:178499509 PDE11A -0.43 -6.02 -0.35 5.77e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg08027265 chr7:2291960 NA -0.46 -6.99 -0.39 2.19e-11 Bipolar disorder and schizophrenia; CESC cis rs2629540 1.000 rs2629540 chr10:126426148 G/C cg08799069 chr10:126477246 METTL10 0.69 8.33 0.46 4.5e-15 Cocaine dependence; CESC cis rs12618769 0.597 rs72821908 chr2:99085359 A/G cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs17125944 0.505 rs77949716 chr14:53204234 G/A cg00686598 chr14:53173677 PSMC6 1.4 11.75 0.59 6.26e-26 Alzheimer's disease (late onset); CESC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg16145915 chr7:1198662 ZFAND2A -0.45 -6.35 -0.36 9.46e-10 Longevity;Endometriosis; CESC cis rs7131987 0.868 rs7958210 chr12:29395181 G/C cg09582351 chr12:29534625 ERGIC2 -0.33 -5.24 -0.31 3.32e-7 QT interval; CESC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg24503407 chr1:205819492 PM20D1 0.42 5.61 0.33 5.13e-8 Parkinson's disease; CESC cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg11952622 chr19:58962976 ZNF324B 0.75 10.84 0.55 6.74e-23 Mean platelet volume; CESC cis rs7937682 0.961 rs7106104 chr11:111635655 T/C cg09085632 chr11:111637200 PPP2R1B 1.1 15.49 0.69 5.53e-39 Primary sclerosing cholangitis; CESC cis rs2439831 0.850 rs3759790 chr15:44121030 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.66 6.03 0.35 5.4e-9 Lung cancer in ever smokers; CESC cis rs1008375 0.872 rs6831115 chr4:17640463 A/G cg16339924 chr4:17578868 LAP3 0.58 7.25 0.41 4.56e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9902453 0.967 rs9913074 chr17:28481199 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.67 0.43 3.29e-13 Coffee consumption (cups per day); CESC cis rs3796352 1.000 rs750474 chr3:53085280 A/C cg07884673 chr3:53033167 SFMBT1 0.55 5.41 0.32 1.4e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs1707322 0.721 rs10749856 chr1:46164846 A/T cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2011503 0.943 rs4239639 chr19:19435876 G/A cg11584989 chr19:19387371 SF4 -0.64 -7.79 -0.43 1.51e-13 Bipolar disorder; CESC cis rs3857067 0.806 rs6858342 chr4:95112318 G/C cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC trans rs7618501 0.633 rs4688755 chr3:50064424 G/A cg21659725 chr3:3221576 CRBN -0.53 -7.47 -0.42 1.15e-12 Intelligence (multi-trait analysis); CESC cis rs2486288 0.656 rs12911861 chr15:45566718 T/C cg09092052 chr15:45571596 NA 0.45 5.24 0.31 3.23e-7 Glomerular filtration rate; CESC cis rs11055008 0.620 rs10845608 chr12:12836088 C/T cg04607235 chr12:12878440 APOLD1 0.52 6.9 0.39 3.79e-11 Pulse pressure; CESC cis rs7044106 0.791 rs10984994 chr9:123478769 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.76 -11.18 -0.57 5.08e-24 Hip circumference adjusted for BMI; CESC cis rs8060686 0.641 rs8044014 chr16:68209872 T/C cg26727032 chr16:67993705 SLC12A4 -0.51 -6.18 -0.36 2.35e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs11864453 0.612 rs12924413 chr16:72129745 T/C cg16558253 chr16:72132732 DHX38 -0.54 -8.47 -0.46 1.7e-15 Fibrinogen levels; CESC cis rs753778 0.570 rs4961335 chr8:142209142 A/G cg18755752 chr8:142205143 DENND3 -0.63 -9.27 -0.49 6.94e-18 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.83 8.2 0.45 1.06e-14 Platelet count; CESC cis rs11077998 0.967 rs60488670 chr17:80522667 T/C cg10255544 chr17:80519551 FOXK2 0.55 8.78 0.47 2.02e-16 Reticulocyte fraction of red cells; CESC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg07153921 chr17:41440717 NA -0.4 -5.24 -0.31 3.33e-7 Menopause (age at onset); CESC cis rs2204008 0.694 rs10880262 chr12:38328696 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.76 0.43 1.86e-13 Bladder cancer; CESC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg16325326 chr1:53192061 ZYG11B 0.85 13.86 0.65 3.32e-33 Monocyte count; CESC cis rs8027181 0.839 rs2304597 chr15:73052431 A/G cg25632853 chr15:73088954 NA 0.3 5.31 0.31 2.29e-7 Triglyceride levels; CESC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs4727027 0.933 rs1468369 chr7:148839840 G/C cg23158103 chr7:148848205 ZNF398 -0.4 -6.51 -0.37 3.67e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9905704 0.609 rs72828712 chr17:56897404 A/T cg12560992 chr17:57184187 TRIM37 0.63 5.8 0.34 1.84e-8 Testicular germ cell tumor; CESC cis rs4629710 0.592 rs4424112 chr6:131563788 C/T cg12606694 chr6:131520996 AKAP7 0.49 5.96 0.34 8.04e-9 Multiple myeloma (IgH translocation); CESC cis rs7259376 0.936 rs8111665 chr19:22588559 C/T cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.76e-7 Menopause (age at onset); CESC cis rs9916302 0.821 rs1966915 chr17:37425262 A/C cg00129232 chr17:37814104 STARD3 -0.53 -6.89 -0.39 4.12e-11 Glomerular filtration rate (creatinine); CESC cis rs1609391 0.567 rs835633 chr3:136676496 T/C cg25687071 chr3:136751404 NA 0.38 5.11 0.3 6.21e-7 Neuroticism; CESC cis rs6540556 0.723 rs11487866 chr1:209892046 G/A cg05527609 chr1:210001259 C1orf107 -0.67 -7.35 -0.41 2.43e-12 Red blood cell count; CESC cis rs1843834 0.611 rs1058360 chr2:225449242 A/T cg22455342 chr2:225449267 CUL3 0.71 9.63 0.51 5.19e-19 IgE levels in asthmatics (D.p. specific); CESC cis rs832540 1.000 rs832540 chr5:56199202 G/A cg14703610 chr5:56206110 C5orf35 0.54 7.22 0.41 5.35e-12 Coronary artery disease; CESC cis rs1506636 0.962 rs10273985 chr7:123309538 A/T cg03229431 chr7:123269106 ASB15 -0.51 -6.63 -0.38 1.88e-10 Plateletcrit;Platelet count; CESC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg05025164 chr4:1340916 KIAA1530 0.38 5.24 0.31 3.21e-7 Longevity; CESC cis rs9814567 1.000 rs9826496 chr3:134224437 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.82 -0.34 1.68e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs3806843 1.000 rs3733707 chr5:140181892 T/C cg26395211 chr5:140044315 WDR55 -0.41 -5.12 -0.3 5.95e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7223966 1.000 rs8067431 chr17:61817048 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.23 0.36 1.8e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.64e-30 Developmental language disorder (linguistic errors); CESC cis rs858239 0.600 rs10241208 chr7:23144914 G/C cg23682824 chr7:23144976 KLHL7 0.51 6.82 0.39 6.16e-11 Cerebrospinal fluid biomarker levels; CESC cis rs28374715 0.578 rs17730589 chr15:41600878 T/C cg20272979 chr15:41787780 ITPKA 0.45 5.14 0.3 5.32e-7 Ulcerative colitis; CESC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.7 -0.33 3.13e-8 Huntington's disease progression; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg10011647 chr11:58892585 FAM111B -0.45 -6.08 -0.35 4.24e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg05275752 chr2:38892887 GALM -0.48 -6.52 -0.37 3.61e-10 5-HTT brain serotonin transporter levels; CESC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg23161317 chr6:28129485 ZNF389 0.49 6.14 0.35 2.99e-9 Parkinson's disease; CESC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg21963583 chr11:68658836 MRPL21 0.4 5.52 0.32 8.06e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6460942 0.915 rs2216050 chr7:12304073 T/C cg02935154 chr7:12443704 VWDE -0.4 -5.54 -0.32 7.3e-8 Coronary artery disease; CESC cis rs858239 0.541 rs4624924 chr7:23168843 A/C cg23682824 chr7:23144976 KLHL7 0.54 7.41 0.41 1.69e-12 Cerebrospinal fluid biomarker levels; CESC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg06808227 chr14:105710500 BRF1 -0.51 -5.78 -0.33 2.13e-8 Mean platelet volume;Platelet distribution width; CESC trans rs7174755 0.558 rs11071975 chr15:68329444 A/C cg00239025 chr2:96937097 CIAO1 0.54 6.6 0.38 2.2e-10 Major depressive disorder; CESC cis rs7259376 0.936 rs17391718 chr19:22554154 A/G cg02657401 chr19:22469223 NA -0.25 -5.05 -0.3 8.34e-7 Menopause (age at onset); CESC cis rs17401966 0.931 rs2276100 chr1:10394536 C/G cg15208524 chr1:10270712 KIF1B 0.43 5.5 0.32 9.01e-8 Hepatocellular carcinoma; CESC cis rs863345 0.901 rs10752625 chr1:158468626 G/A cg12129480 chr1:158549410 OR10X1 -0.31 -6.23 -0.36 1.78e-9 Pneumococcal bacteremia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15880211 chr22:50250494 ZBED4 -0.52 -6.57 -0.37 2.61e-10 Gut microbiome composition (summer); CESC cis rs13242816 1.000 rs62468976 chr7:116126891 C/G cg04696780 chr7:116139425 CAV2 -0.62 -5.68 -0.33 3.58e-8 P wave duration; CESC cis rs2228479 0.850 rs74251568 chr16:89903416 A/C cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs6439153 0.839 rs2624901 chr3:128677188 C/T cg25356066 chr3:128598488 ACAD9 -0.41 -5.36 -0.31 1.81e-7 Pneumococcal bacteremia; CESC cis rs2860975 0.905 rs10882516 chr10:96791217 A/C cg09036531 chr10:96991505 NA -0.35 -5.13 -0.3 5.74e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.07 10.45 0.54 1.23e-21 Platelet count; CESC cis rs8058578 0.775 rs8046391 chr16:30836648 G/C cg00531865 chr16:30841666 NA -0.41 -5.31 -0.31 2.32e-7 Multiple myeloma; CESC cis rs3820068 0.580 rs36100011 chr1:16046920 C/T cg13390004 chr1:15929781 NA 0.34 5.21 0.3 3.79e-7 Systolic blood pressure; CESC cis rs2204008 0.837 rs11495548 chr12:38076756 C/T cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs11252926 0.673 rs10795161 chr10:497748 G/T cg18196295 chr10:418757 DIP2C 0.49 6.94 0.39 2.96e-11 Psychosis in Alzheimer's disease; CESC cis rs2180341 0.618 rs11154398 chr6:127654281 C/A cg24812749 chr6:127587940 RNF146 0.6 8.02 0.44 3.42e-14 Breast cancer; CESC cis rs1198430 0.568 rs1119439 chr1:23828904 A/T cg22040403 chr1:23858016 E2F2 0.61 5.62 0.33 4.79e-8 Total cholesterol levels; CESC trans rs62103177 0.714 rs7227962 chr18:77603283 T/G cg05926928 chr17:57297772 GDPD1 0.75 7.99 0.44 4.26e-14 Opioid sensitivity; CESC cis rs2637266 0.729 rs860166 chr10:78549111 C/T cg18941641 chr10:78392320 NA 0.4 7.63 0.42 4.22e-13 Pulmonary function; CESC cis rs7917772 0.503 rs7100753 chr10:104300979 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.19 0.3 4.1e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7296418 0.961 rs1790121 chr12:123604492 G/A cg05973401 chr12:123451056 ABCB9 0.56 7.25 0.41 4.58e-12 Platelet count; CESC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg03388025 chr16:89894329 SPIRE2 -0.31 -5.95 -0.34 8.44e-9 Vitiligo; CESC cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg00701064 chr4:6280414 WFS1 0.69 11.92 0.59 1.61e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09344629 chr2:128471493 WDR33 0.47 6.56 0.37 2.77e-10 Fibrinogen levels; CESC cis rs6582630 0.533 rs4103689 chr12:38702980 A/C cg26384229 chr12:38710491 ALG10B 0.59 8.5 0.46 1.37e-15 Drug-induced liver injury (flucloxacillin); CESC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg02269571 chr22:50332266 NA -0.57 -6.99 -0.39 2.29e-11 Schizophrenia; CESC cis rs4460629 0.742 rs7365544 chr1:155068748 C/A cg01019262 chr1:155095195 NA -0.3 -5.05 -0.3 8.13e-7 Serum magnesium levels; CESC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg02428538 chr16:24856791 SLC5A11 -0.47 -5.03 -0.3 9.12e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 1.000 rs4636974 chr17:56965373 C/G cg12560992 chr17:57184187 TRIM37 0.93 15.52 0.69 4.53e-39 Intelligence (multi-trait analysis); CESC cis rs12079745 0.590 rs74317850 chr1:169169924 T/G cg09363564 chr1:169337483 NME7;BLZF1 -1.11 -6.52 -0.37 3.5e-10 QT interval; CESC cis rs3812831 0.599 rs428636 chr13:114927133 T/C cg08824895 chr13:115047677 UPF3A 0.41 5.37 0.31 1.76e-7 Schizophrenia; CESC cis rs9346455 0.881 rs16881116 chr6:72031488 C/A cg27238071 chr6:71998145 OGFRL1 0.6 5.13 0.3 5.48e-7 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs4253772 0.720 rs4253778 chr22:46630634 C/G cg09491104 chr22:46646882 C22orf40 -0.57 -8.83 -0.48 1.5e-16 LDL cholesterol;Cholesterol, total; CESC cis rs7851660 0.805 rs4255258 chr9:100647545 A/G cg13688889 chr9:100608707 NA -0.65 -9.02 -0.48 3.79e-17 Strep throat; CESC cis rs2072499 0.750 rs72708291 chr1:156177285 A/T cg24450063 chr1:156163899 SLC25A44 0.9 11.26 0.57 2.62e-24 Testicular germ cell tumor; CESC cis rs7264396 0.635 rs6060719 chr20:34546013 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.57 6.83 0.39 5.63e-11 Total cholesterol levels; CESC cis rs6598955 0.614 rs1134584 chr1:26608828 G/A cg00852783 chr1:26633632 UBXN11 0.37 5.44 0.32 1.18e-7 Obesity-related traits; CESC cis rs113835537 0.597 rs4576 chr11:66331000 A/G cg24851651 chr11:66362959 CCS 0.48 5.89 0.34 1.16e-8 Airway imaging phenotypes; CESC trans rs17764205 0.777 rs17696630 chr19:3261995 A/G cg18335933 chr6:2765945 WRNIP1 -0.77 -6.2 -0.36 2.15e-9 Bipolar disorder and schizophrenia; CESC trans rs7644516 0.646 rs2052761 chr3:25924669 A/G cg16041123 chr14:71373980 PCNX 0.49 6.07 0.35 4.33e-9 DNA methylation (variation); CESC cis rs61935443 0.562 rs11107791 chr12:95316374 G/A cg21533806 chr12:95267307 NA 0.5 5.41 0.32 1.4e-7 Schizophrenia; CESC cis rs10465746 0.752 rs10874426 chr1:84451820 A/G cg10977910 chr1:84465055 TTLL7 0.52 7.22 0.41 5.38e-12 Obesity-related traits; CESC cis rs116095464 0.614 rs10067482 chr5:219328 T/G cg10591111 chr5:226296 SDHA -0.51 -6.35 -0.36 9.22e-10 Breast cancer; CESC cis rs61931739 0.500 rs10844863 chr12:34532284 C/T cg06521331 chr12:34319734 NA -0.37 -5.15 -0.3 5.19e-7 Morning vs. evening chronotype; CESC cis rs919433 0.783 rs3097383 chr2:198236887 A/G cg20885578 chr2:198174922 NA 0.41 5.36 0.31 1.79e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.82 0.48 1.53e-16 Bipolar disorder; CESC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg00945038 chr17:61921165 SMARCD2 0.35 5.11 0.3 6.22e-7 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26012578 chr2:122125185 CLASP1 0.53 7.41 0.41 1.68e-12 Fibrinogen levels; CESC cis rs4891159 0.790 rs8098821 chr18:74140345 T/C cg24786174 chr18:74118243 ZNF516 -0.73 -10.73 -0.55 1.55e-22 Longevity; CESC cis rs2066819 1.000 rs57870697 chr12:56752874 A/G cg26714650 chr12:56694279 CS -1.39 -9.05 -0.49 3.19e-17 Psoriasis vulgaris; CESC cis rs4604732 0.578 rs7525209 chr1:247627404 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2841277 0.676 rs4264326 chr14:105411700 A/G cg19901468 chr14:105411992 AHNAK2 -0.6 -8.78 -0.47 2.03e-16 Rheumatoid arthritis; CESC cis rs9457247 0.967 rs2149084 chr6:167370988 G/C cg23791538 chr6:167370224 RNASET2 0.61 8.62 0.47 6.14e-16 Crohn's disease; CESC cis rs9790314 0.723 rs10936223 chr3:160884313 C/A cg03342759 chr3:160939853 NMD3 -0.36 -5.05 -0.3 8.4e-7 Morning vs. evening chronotype; CESC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg05863683 chr7:1912471 MAD1L1 0.38 5.52 0.32 7.99e-8 Bipolar disorder and schizophrenia; CESC cis rs17362650 0.653 rs35968355 chr2:9551713 G/A cg12832956 chr2:9616023 IAH1 -0.56 -6.47 -0.37 4.74e-10 Alcohol dependence (age at onset); CESC cis rs9902453 0.904 rs4598962 chr17:28293948 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 8.71 0.47 3.26e-16 Coffee consumption (cups per day); CESC cis rs12142240 0.698 rs4372193 chr1:46853233 G/T cg00530320 chr1:46809349 NSUN4 0.6 8.3 0.45 5.19e-15 Menopause (age at onset); CESC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.25 -0.31 3.09e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs763121 0.819 rs6001205 chr22:39100264 T/A cg06544989 chr22:39130855 UNC84B 0.52 9.04 0.49 3.39e-17 Menopause (age at onset); CESC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg10691866 chr7:65817282 TPST1 0.33 5.42 0.32 1.33e-7 Aortic root size; CESC cis rs4588572 0.606 rs6859161 chr5:77742776 A/G cg11547950 chr5:77652471 NA -0.4 -5.46 -0.32 1.12e-7 Triglycerides; CESC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg22963979 chr7:1858916 MAD1L1 -0.43 -5.89 -0.34 1.2e-8 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09388058 chr16:47494735 PHKB;ITFG1 0.68 7.84 0.43 1.12e-13 Gut microbiome composition (summer); CESC cis rs4689388 0.750 rs12642481 chr4:6301058 G/A cg14416269 chr4:6271139 WFS1 0.39 5.89 0.34 1.19e-8 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs644799 1.000 rs1784135 chr11:95531748 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9837602 1.000 rs793472 chr3:99546110 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.52 -7.0 -0.4 2.06e-11 Breast cancer; CESC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg01988459 chr11:68622903 NA -0.39 -5.21 -0.3 3.76e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg18337363 chr3:52569053 NT5DC2 0.31 5.95 0.34 8.63e-9 Electroencephalogram traits; CESC cis rs698813 0.604 rs7606004 chr2:44479983 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.38 0.31 1.62e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15461550 chr8:4644719 CSMD1 -0.5 -7.74 -0.43 2.16e-13 Gut microbiota (bacterial taxa); CESC trans rs78049276 0.736 rs6841581 chr4:148401190 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.68 -7.17 -0.4 7.54e-12 Pulse pressure; CESC cis rs433852 0.904 rs8102492 chr19:49140809 A/C cg06677660 chr19:49140777 SEC1;DBP 0.58 7.27 0.41 4.07e-12 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; CESC cis rs2760061 0.545 rs1636196 chr1:228204030 A/G cg02753203 chr1:228287806 NA 0.79 11.24 0.57 3.22e-24 Diastolic blood pressure; CESC cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg24130564 chr14:104152367 KLC1 -0.49 -6.43 -0.37 5.96e-10 Reticulocyte count; CESC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg00149659 chr3:10157352 C3orf10 0.72 8.99 0.48 4.93e-17 Alzheimer's disease; CESC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg26939375 chr7:64535504 NA -0.76 -10.82 -0.55 7.64e-23 Calcium levels; CESC cis rs727505 0.754 rs55905546 chr7:124783064 A/C cg23710748 chr7:124431027 NA -0.38 -6.2 -0.36 2.14e-9 Lewy body disease; CESC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg05863683 chr7:1912471 MAD1L1 0.49 7.56 0.42 6.59e-13 Bipolar disorder and schizophrenia; CESC cis rs6430585 0.583 rs73957037 chr2:136588031 C/A cg07169764 chr2:136633963 MCM6 1.21 18.18 0.74 1.72e-48 Corneal structure; CESC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg18876405 chr7:65276391 NA 0.47 6.36 0.36 8.96e-10 Aortic root size; CESC cis rs2070488 0.775 rs13072731 chr3:38533335 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.83 13.6 0.64 2.69e-32 Electrocardiographic conduction measures; CESC trans rs629535 0.862 rs654604 chr8:70048939 C/A cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg11764359 chr7:65958608 NA 0.94 14.73 0.67 2.83e-36 Aortic root size; CESC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg02807482 chr3:125708958 NA -0.4 -5.14 -0.3 5.45e-7 Blood pressure (smoking interaction); CESC cis rs7772486 0.754 rs6570703 chr6:145957052 C/T cg23711669 chr6:146136114 FBXO30 0.89 13.03 0.62 2.53e-30 Lobe attachment (rater-scored or self-reported); CESC trans rs9325144 0.647 rs34963631 chr12:38912260 T/A cg23762105 chr12:34175262 ALG10 0.47 6.12 0.35 3.3e-9 Morning vs. evening chronotype; CESC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg05861140 chr6:150128134 PCMT1 -0.38 -5.43 -0.32 1.29e-7 Lung cancer; CESC cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.79 8.79 0.47 1.98e-16 Alzheimer's disease; CESC trans rs9467711 0.606 rs9357006 chr6:26364628 A/C cg06606381 chr12:133084897 FBRSL1 -0.76 -7.01 -0.4 1.97e-11 Autism spectrum disorder or schizophrenia; CESC cis rs9303401 0.659 rs36109237 chr17:56653834 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.56e-29 Cognitive test performance; CESC trans rs4942242 1.000 rs7331003 chr13:44230253 C/T cg19169023 chr15:41853346 TYRO3 -0.44 -6.36 -0.36 8.92e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg03605463 chr16:89740564 NA -0.6 -7.58 -0.42 5.85e-13 Vitiligo; CESC cis rs6665290 0.901 rs7535826 chr1:227213968 A/C cg10327440 chr1:227177885 CDC42BPA 1.08 20.93 0.79 4.28e-58 Myeloid white cell count; CESC cis rs10791323 0.521 rs10894756 chr11:133745852 G/A cg15485101 chr11:133734466 NA 0.3 5.13 0.3 5.52e-7 Childhood ear infection; CESC cis rs4423214 0.559 rs7949129 chr11:71193135 G/C cg05163923 chr11:71159392 DHCR7 -0.61 -6.16 -0.35 2.66e-9 Vitamin D levels; CESC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg10295955 chr4:187884368 NA -1.04 -20.81 -0.79 1.12e-57 Lobe attachment (rater-scored or self-reported); CESC cis rs8067354 0.645 rs2645489 chr17:57883371 T/G cg13753209 chr17:57696993 CLTC 0.66 8.26 0.45 7.21e-15 Hemoglobin concentration; CESC cis rs12530845 0.943 rs58577912 chr7:135329269 T/G cg23117316 chr7:135346802 PL-5283 -0.45 -5.58 -0.32 6.05e-8 Red blood cell traits; CESC cis rs2239547 0.618 rs13083728 chr3:52868445 G/A cg11645453 chr3:52864694 ITIH4 0.36 6.5 0.37 3.98e-10 Schizophrenia; CESC cis rs9517302 0.847 rs9517300 chr13:99095057 T/C cg22223119 chr13:99095684 FARP1 -0.56 -8.54 -0.46 1.06e-15 Obesity-related traits; CESC cis rs4481887 0.760 rs4559544 chr1:248412507 T/G cg00666640 chr1:248458726 OR2T12 0.33 5.55 0.32 6.83e-8 Common traits (Other); CESC cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg15017067 chr4:17643749 FAM184B 0.38 5.35 0.31 1.86e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.24 -0.31 3.23e-7 Lung cancer; CESC cis rs897984 0.762 rs12931046 chr16:30987144 G/A cg02466173 chr16:30829666 NA 0.48 7.99 0.44 4.09e-14 Dementia with Lewy bodies; CESC cis rs7845219 0.544 rs9643350 chr8:95917276 C/A cg13393036 chr8:95962371 TP53INP1 -0.41 -7.76 -0.43 1.86e-13 Type 2 diabetes; CESC cis rs6582630 0.502 rs11520261 chr12:38332019 T/G cg26384229 chr12:38710491 ALG10B 0.64 9.46 0.5 1.69e-18 Drug-induced liver injury (flucloxacillin); CESC cis rs7116495 1.000 rs2511076 chr11:71783827 A/G cg10381502 chr11:71823885 C11orf51 -0.68 -5.48 -0.32 9.68e-8 Severe influenza A (H1N1) infection; CESC cis rs6460942 0.591 rs62448728 chr7:12332915 A/T cg06484146 chr7:12443880 VWDE -0.66 -7.27 -0.41 4.01e-12 Coronary artery disease; CESC cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.56 0.32 6.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9287719 0.934 rs6706763 chr2:10751407 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs6812193 0.518 rs28498588 chr4:77188766 A/T cg20311846 chr4:77356250 SHROOM3 0.28 5.14 0.3 5.41e-7 Parkinson's disease; CESC cis rs734999 0.588 rs745367 chr1:2524457 T/C cg18854424 chr1:2615690 NA 0.28 5.48 0.32 1.01e-7 Ulcerative colitis; CESC cis rs7927592 0.956 rs12281742 chr11:68303629 C/T cg16797656 chr11:68205561 LRP5 -0.41 -6.19 -0.36 2.34e-9 Total body bone mineral density; CESC cis rs11718455 0.960 rs3843372 chr3:43997666 C/T cg08738300 chr3:44038990 NA 0.44 5.73 0.33 2.75e-8 Coronary artery disease; CESC cis rs17750015 0.733 rs7506986 chr18:54404558 C/T cg18434998 chr18:54306185 TXNL1 -0.4 -5.18 -0.3 4.4e-7 Depression and alcohol dependence; CESC cis rs7824557 0.688 rs2572397 chr8:11176403 G/A cg21775007 chr8:11205619 TDH 0.41 5.71 0.33 3.09e-8 Retinal vascular caliber; CESC cis rs7208859 0.623 rs73269913 chr17:29092183 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1008375 1.000 rs1121091 chr4:17676386 A/C cg16339924 chr4:17578868 LAP3 0.51 6.44 0.37 5.73e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4595586 0.545 rs12809435 chr12:39404341 C/T cg26384229 chr12:38710491 ALG10B -0.55 -7.72 -0.43 2.41e-13 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04421424 chr19:57791681 ZNF460 -0.46 -6.69 -0.38 1.3e-10 Gambling; CESC cis rs941873 0.900 rs4979862 chr10:81131599 G/A cg09469691 chr10:81107165 PPIF 0.55 7.49 0.42 1.06e-12 Height; CESC cis rs2425143 0.730 rs6060624 chr20:34413663 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.17 -0.4 7.27e-12 Blood protein levels; CESC cis rs911555 0.755 rs2756132 chr14:103967820 C/G cg12935359 chr14:103987150 CKB 0.6 8.86 0.48 1.16e-16 Intelligence (multi-trait analysis); CESC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg18099408 chr3:52552593 STAB1 -0.31 -5.16 -0.3 4.79e-7 Bipolar disorder; CESC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.09 10.29 0.53 4.06e-21 Platelet count; CESC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg24675658 chr1:53192096 ZYG11B -0.6 -7.61 -0.42 4.78e-13 Monocyte count; CESC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg06456125 chr7:65229604 NA -0.4 -5.24 -0.31 3.32e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13396246 chr19:54619133 PRPF31;TFPT 0.59 6.88 0.39 4.19e-11 Gut microbiome composition (summer); CESC cis rs5167 0.506 rs7257916 chr19:45482884 T/C cg13119609 chr19:45449297 APOC2 -0.52 -7.96 -0.44 4.96e-14 Blood protein levels; CESC cis rs6968419 0.714 rs3807980 chr7:115893647 A/G cg02561103 chr7:115862891 TES -0.39 -5.14 -0.3 5.44e-7 Intraocular pressure; CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg16145915 chr7:1198662 ZFAND2A -0.73 -12.04 -0.59 6.62e-27 Longevity;Endometriosis; CESC cis rs8017423 0.967 rs4904658 chr14:90721640 C/T cg14092571 chr14:90743983 NA -0.55 -8.25 -0.45 7.71e-15 Mortality in heart failure; CESC cis rs10129255 0.500 rs34326748 chr14:107190760 G/C cg23076370 chr14:107095027 NA -0.65 -9.64 -0.51 4.66e-19 Kawasaki disease; CESC cis rs7845219 0.544 rs2945554 chr8:95939594 C/A cg16049864 chr8:95962084 TP53INP1 -0.47 -6.9 -0.39 3.92e-11 Type 2 diabetes; CESC cis rs2455799 0.613 rs13060772 chr3:15896795 C/T cg16303742 chr3:15540471 COLQ -0.37 -5.53 -0.32 7.49e-8 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07556218 chr8:144623533 ZC3H3 -0.51 -6.51 -0.37 3.68e-10 Fibrinogen levels; CESC cis rs7937682 0.889 rs521155 chr11:111492563 G/A cg09085632 chr11:111637200 PPP2R1B -0.95 -14.6 -0.67 8.26e-36 Primary sclerosing cholangitis; CESC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg16145915 chr7:1198662 ZFAND2A -0.5 -5.58 -0.32 5.95e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg03609598 chr5:56110824 MAP3K1 -0.49 -5.32 -0.31 2.16e-7 Initial pursuit acceleration; CESC cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg15605315 chr1:45957053 TESK2 0.43 5.48 0.32 1.01e-7 High light scatter reticulocyte count; CESC cis rs4919044 0.756 rs835257 chr10:94779801 T/A cg00487187 chr10:94451625 HHEX -0.45 -5.05 -0.3 8.21e-7 Coronary artery disease; CESC cis rs8114671 0.562 rs6087649 chr20:33510662 A/G cg06115741 chr20:33292138 TP53INP2 0.46 5.58 0.32 6.06e-8 Height; CESC cis rs965469 0.625 rs1043159 chr20:3232031 C/T cg25506879 chr20:3388711 C20orf194 -0.55 -6.62 -0.38 1.99e-10 IFN-related cytopenia; CESC cis rs9291683 0.525 rs12506455 chr4:10031569 T/A cg00071950 chr4:10020882 SLC2A9 0.88 16.15 0.7 2.65e-41 Bone mineral density; CESC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg04414720 chr1:150670196 GOLPH3L 0.56 7.36 0.41 2.26e-12 Melanoma; CESC trans rs7715474 0.738 rs7728749 chr5:120097929 C/T cg12384126 chr1:185285600 IVNS1ABP -0.46 -6.02 -0.35 5.66e-9 Post bronchodilator FEV1/FVC ratio; CESC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg27125505 chr17:43679177 LOC644172 -0.48 -6.74 -0.38 1.01e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs8005677 1.000 rs1956881 chr14:23394069 A/C cg01529538 chr14:23388837 RBM23 0.51 6.91 0.39 3.52e-11 Cognitive ability (multi-trait analysis); CESC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg03352830 chr11:487213 PTDSS2 0.74 7.23 0.41 5.09e-12 Body mass index; CESC cis rs6060717 0.654 rs6060686 chr20:34512606 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.84 0.39 5.4e-11 Hip circumference adjusted for BMI; CESC cis rs11264213 0.901 rs72661644 chr1:36453894 G/A cg27506609 chr1:36549197 TEKT2 0.66 5.6 0.33 5.44e-8 Schizophrenia; CESC cis rs17384381 0.953 rs12130145 chr1:85828970 G/C cg16011679 chr1:85725395 C1orf52 0.79 7.92 0.44 6.43e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs858239 0.602 rs6953996 chr7:23175946 A/G cg23682824 chr7:23144976 KLHL7 0.49 6.37 0.36 8.51e-10 Cerebrospinal fluid biomarker levels; CESC cis rs6582630 0.555 rs11180986 chr12:38264486 G/A cg26384229 chr12:38710491 ALG10B -0.46 -6.03 -0.35 5.38e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7264396 0.508 rs6060739 chr20:34567592 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.49 5.7 0.33 3.15e-8 Total cholesterol levels; CESC trans rs877282 0.945 rs12776447 chr10:790625 A/G cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs7680126 0.632 rs78030862 chr4:10150412 G/A cg00071950 chr4:10020882 SLC2A9 -0.6 -6.48 -0.37 4.33e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs3747547 0.539 rs72726090 chr9:38124186 T/C cg13774184 chr9:37916125 SHB -0.67 -6.03 -0.35 5.38e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs7116495 0.609 rs10736783 chr11:71654143 G/A cg07596299 chr11:71824057 C11orf51 -0.76 -5.21 -0.3 3.77e-7 Severe influenza A (H1N1) infection; CESC cis rs644799 0.965 rs602512 chr11:95561682 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.78 0.38 7.87e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10089 1.000 rs1864922 chr5:127420700 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.48 0.54 9.74e-22 Ileal carcinoids; CESC cis rs10504073 0.584 rs62507177 chr8:49937306 C/A cg00325661 chr8:49890786 NA 0.58 8.62 0.47 6.03e-16 Blood metabolite ratios; CESC cis rs9916302 0.904 rs12452509 chr17:37574722 G/A cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 4.03e-10 Glomerular filtration rate (creatinine); CESC cis rs8062405 0.721 rs151181 chr16:28490517 A/G cg05966235 chr16:28915196 ATP2A1 0.36 5.23 0.31 3.48e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.53 5.21 0.31 3.73e-7 Cerebrospinal P-tau181p levels; CESC cis rs854765 0.583 rs8070128 chr17:17804725 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.46 -5.91 -0.34 1.02e-8 Total body bone mineral density; CESC cis rs12137294 0.866 rs896318 chr1:205205784 A/G cg21643547 chr1:205240462 TMCC2 -0.35 -5.65 -0.33 4.24e-8 Red cell distribution width; CESC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 6.25 0.36 1.59e-9 Electroencephalogram traits; CESC cis rs4568518 0.740 rs12699924 chr7:18010391 A/G cg03009463 chr7:17980271 SNX13 0.47 6.15 0.35 2.9e-9 Measles; CESC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.07 10.75 0.55 1.35e-22 Platelet count; CESC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg23978390 chr7:1156363 C7orf50 0.53 7.11 0.4 1.08e-11 Longevity;Endometriosis; CESC cis rs2072732 0.861 rs56398543 chr1:2950237 G/A cg03976712 chr1:2946727 NA 0.33 5.5 0.32 8.8e-8 Plateletcrit; CESC cis rs2228479 0.850 rs1800344 chr16:89816367 T/G cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs2243480 1.000 rs34933526 chr7:65383199 A/G cg25894440 chr7:65020034 NA -0.59 -5.07 -0.3 7.57e-7 Diabetic kidney disease; CESC cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg20307385 chr11:47447363 PSMC3 -0.63 -7.46 -0.42 1.24e-12 Subjective well-being; CESC cis rs2806561 0.765 rs1612905 chr1:23510023 G/T cg12483005 chr1:23474871 LUZP1 0.38 6.01 0.35 6.04e-9 Height; CESC cis rs1580019 0.961 rs4255041 chr7:32496383 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.15 0.53 1.14e-20 Cognitive ability; CESC cis rs4722166 0.532 rs6963591 chr7:22757270 G/T cg05472934 chr7:22766657 IL6 -0.49 -6.4 -0.37 6.84e-10 Lung cancer; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg13709765 chr18:3451484 TGIF1 -0.41 -6.07 -0.35 4.44e-9 Vertical cup-disc ratio; CESC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg23161317 chr6:28129485 ZNF389 0.46 6.26 0.36 1.54e-9 Parkinson's disease; CESC cis rs8180040 0.764 rs11708451 chr3:47198826 G/A cg27129171 chr3:47204927 SETD2 0.69 10.44 0.54 1.33e-21 Colorectal cancer; CESC cis rs2294693 0.679 rs12200923 chr6:40970092 T/G cg14769373 chr6:40998127 UNC5CL -0.42 -5.14 -0.3 5.46e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs1322639 0.592 rs7743597 chr6:169591678 T/C cg03254818 chr6:169586852 NA 0.43 6.23 0.36 1.77e-9 Pulse pressure; CESC cis rs919433 0.927 rs3843857 chr2:198195965 T/C cg03934865 chr2:198174659 NA -0.48 -6.9 -0.39 3.77e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs11030122 0.673 rs4910869 chr11:4006438 C/T cg18678763 chr11:4115507 RRM1 -0.47 -6.22 -0.36 1.95e-9 Mean platelet volume;Platelet distribution width; CESC cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.47 0.46 1.72e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg05863683 chr7:1912471 MAD1L1 0.44 6.8 0.39 6.97e-11 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24972080 chr11:65154083 FRMD8 0.6 6.98 0.39 2.39e-11 Gut microbiome composition (summer); CESC cis rs2463822 0.920 rs72923207 chr11:62117959 A/G cg06239285 chr11:62104954 ASRGL1 -1.04 -8.88 -0.48 1.02e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.93 0.34 9.38e-9 Bipolar disorder; CESC cis rs6570726 0.846 rs973856 chr6:145781916 C/T cg23711669 chr6:146136114 FBXO30 -0.83 -12.39 -0.61 4.12e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7511006 1.000 rs7290710 chr22:50677454 C/T cg16473166 chr22:50639996 SELO 0.5 6.26 0.36 1.54e-9 Obesity-related traits; CESC cis rs10911251 0.508 rs729672 chr1:183109236 G/A ch.1.3577855R chr1:183094577 LAMC1 0.82 12.85 0.62 1.02e-29 Colorectal cancer; CESC cis rs6690583 0.623 rs12042845 chr1:85429801 A/G cg22153463 chr1:85462885 MCOLN2 0.76 7.47 0.42 1.14e-12 Serum sulfate level; CESC cis rs3820068 0.532 rs6701009 chr1:15935614 T/C cg17385448 chr1:15911702 AGMAT 0.43 7.11 0.4 1.11e-11 Systolic blood pressure; CESC cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg00409905 chr10:38381863 ZNF37A -0.45 -6.0 -0.35 6.61e-9 Extrinsic epigenetic age acceleration; CESC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 7.01 0.4 1.97e-11 Bipolar disorder; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg05243909 chr16:2097910 NTHL1;TSC2 -0.52 -6.03 -0.35 5.52e-9 Gut microbiota (bacterial taxa); CESC cis rs6693567 0.545 rs5011187 chr1:150422761 T/C cg09579323 chr1:150459698 TARS2 0.48 6.0 0.35 6.34e-9 Migraine; CESC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.63 0.38 1.87e-10 Prudent dietary pattern; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04529868 chr14:65381343 CHURC1 -0.45 -6.61 -0.38 2.09e-10 Gambling; CESC trans rs5756813 0.754 rs8136757 chr22:38185971 A/G cg19894588 chr14:64061835 NA -0.64 -8.24 -0.45 7.83e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs3806843 0.735 rs2530240 chr5:140060547 T/C cg26395211 chr5:140044315 WDR55 0.47 6.03 0.35 5.51e-9 Depressive symptoms (multi-trait analysis); CESC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg11494091 chr17:61959527 GH2 0.71 12.02 0.59 7.35e-27 Prudent dietary pattern; CESC cis rs1559088 1.000 rs1974783 chr19:33551507 C/G cg27124370 chr19:33622961 WDR88 0.42 5.34 0.31 1.98e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7267979 1.000 rs2257982 chr20:25269630 A/G cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs796364 0.806 rs10931887 chr2:200968905 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.74 -6.39 -0.37 7.31e-10 Schizophrenia; CESC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.67 -0.33 3.8e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs61148964 0.826 rs73156281 chr22:37234612 C/T cg14267671 chr19:45572412 SFRS16 0.67 6.22 0.36 1.95e-9 Scarlet fever; CESC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.35 0.54 2.67e-21 Prudent dietary pattern; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03828693 chr10:63661686 ARID5B 0.5 7.26 0.41 4.38e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.74 -0.38 9.93e-11 Electroencephalogram traits; CESC cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg05472934 chr7:22766657 IL6 0.8 10.05 0.53 2.41e-20 Lung cancer; CESC cis rs11723261 0.582 rs3747693 chr4:124375 T/G cg12746427 chr4:53362 ZNF718;ZNF595 0.5 6.45 0.37 5.22e-10 Immune response to smallpox vaccine (IL-6); CESC cis rs1538970 0.924 rs4660858 chr1:45936351 G/A cg03146154 chr1:46216737 IPP 0.46 5.28 0.31 2.65e-7 Platelet count; CESC cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg19193384 chr17:30244184 NA -0.66 -6.21 -0.36 2.01e-9 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01905589 chr1:26856408 RPS6KA1 0.59 7.02 0.4 1.91e-11 Gut microbiome composition (summer); CESC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.16 0.81 2.75e-62 Prudent dietary pattern; CESC cis rs2832191 1.000 rs8131214 chr21:30483386 T/G cg08807101 chr21:30365312 RNF160 -0.66 -8.93 -0.48 7.14e-17 Dental caries; CESC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg09509183 chr1:209979624 IRF6 0.51 5.33 0.31 2.07e-7 Cleft lip with or without cleft palate; CESC cis rs5753618 0.561 rs4820043 chr22:31647094 A/G cg13145458 chr22:31556086 RNF185 0.48 5.37 0.31 1.71e-7 Colorectal cancer; CESC cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -8.14 -0.45 1.51e-14 Hemoglobin concentration; CESC cis rs10493773 0.674 rs414618 chr1:86220418 G/A cg17807903 chr1:86174739 ZNHIT6 0.41 5.92 0.34 1.02e-8 Urate levels in overweight individuals; CESC cis rs854765 0.893 rs712265 chr17:18008447 G/A cg16928487 chr17:17741425 SREBF1 0.56 9.12 0.49 1.93e-17 Total body bone mineral density; CESC cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg20891283 chr12:69753455 YEATS4 0.91 15.03 0.68 2.41e-37 Blood protein levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg00697668 chr14:105617575 JAG2 -0.47 -6.23 -0.36 1.86e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3091242 0.904 rs6661533 chr1:25771715 A/G cg02931644 chr1:25747376 RHCE 0.47 8.04 0.44 3.09e-14 Erythrocyte sedimentation rate; CESC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg06221963 chr1:154839813 KCNN3 0.66 11.63 0.58 1.58e-25 Prostate cancer; CESC cis rs3793917 0.948 rs3750848 chr10:124215315 A/C cg24884230 chr10:124216658 ARMS2 0.31 5.12 0.3 5.94e-7 Age-related macular degeneration; CESC cis rs2549003 1.000 rs7734334 chr5:131815004 C/A cg00255919 chr5:131827918 IRF1 0.51 8.71 0.47 3.26e-16 Asthma (sex interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.2.747167F chr2:30383352 YPEL5 -0.57 -7.15 -0.4 8.41e-12 Gut microbiome composition (summer); CESC cis rs644799 1.000 rs527899 chr11:95529242 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs17376456 0.877 rs10065056 chr5:93380123 G/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.18 0.3 4.41e-7 Diabetic retinopathy; CESC cis rs3806843 0.735 rs2563335 chr5:140044292 A/C cg16179182 chr5:140090404 VTRNA1-1 -0.42 -5.3 -0.31 2.4e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7296418 0.961 rs11608811 chr12:123529056 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.04 -0.3 8.54e-7 Platelet count; CESC cis rs1559088 0.522 rs7254912 chr19:33554151 A/G cg03563238 chr19:33554763 RHPN2 -0.32 -5.78 -0.33 2.08e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2559856 0.935 rs2695287 chr12:102088361 T/C cg15068132 chr12:102092402 CHPT1 -0.42 -5.59 -0.32 5.57e-8 Blood protein levels; CESC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg13114125 chr14:105738426 BRF1 0.79 9.33 0.5 4.29e-18 Mean platelet volume;Platelet distribution width; CESC cis rs7772486 0.743 rs9376955 chr6:145949404 T/A cg23711669 chr6:146136114 FBXO30 0.82 11.91 0.59 1.77e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs9715521 0.677 rs6822690 chr4:59853530 A/G cg11281224 chr4:60001000 NA -0.52 -7.18 -0.4 7.11e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9611565 0.921 rs3927 chr22:41722864 A/G cg06634786 chr22:41940651 POLR3H -0.6 -6.29 -0.36 1.27e-9 Vitiligo; CESC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg18337363 chr3:52569053 NT5DC2 0.28 5.05 0.3 8.38e-7 Bipolar disorder; CESC cis rs7191439 0.584 rs8048897 chr16:88744470 T/G cg27087555 chr16:88793112 FAM38A -1.13 -6.74 -0.38 9.85e-11 Plateletcrit; CESC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg04546413 chr19:29218101 NA 0.56 7.91 0.44 6.84e-14 Methadone dose in opioid dependence; CESC trans rs7246760 0.867 rs1115825 chr19:9786121 C/G cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs2415984 0.540 rs1494095 chr14:46960671 T/C cg14871534 chr14:47121158 RPL10L 0.35 5.32 0.31 2.24e-7 Number of children ever born; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13883939 chr12:118541731 VSIG10 0.38 6.09 0.35 3.9e-9 Gambling; CESC cis rs12701220 0.522 rs12334290 chr7:1054517 A/G cg04025307 chr7:1156635 C7orf50 0.37 5.57 0.32 6.18e-8 Bronchopulmonary dysplasia; CESC cis rs933688 1.000 rs9293568 chr5:90737845 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.09 12.09 0.6 4.37e-27 Smoking behavior; CESC cis rs4654899 0.865 rs10493006 chr1:21375904 G/A cg05370193 chr1:21551575 ECE1 0.42 6.15 0.35 2.79e-9 Superior frontal gyrus grey matter volume; CESC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg07701084 chr6:150067640 NUP43 0.42 5.63 0.33 4.6e-8 Lung cancer; CESC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg18876405 chr7:65276391 NA 0.54 7.36 0.41 2.37e-12 Aortic root size; CESC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg12963246 chr6:28129442 ZNF389 0.56 7.62 0.42 4.43e-13 Depression; CESC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg23048001 chr7:2026167 MAD1L1 0.4 5.24 0.31 3.21e-7 Schizophrenia; CESC cis rs977987 0.843 rs28558946 chr16:75489322 G/T cg03315344 chr16:75512273 CHST6 0.46 6.73 0.38 1.02e-10 Dupuytren's disease; CESC cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg18876405 chr7:65276391 NA 0.45 5.04 0.3 8.75e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01623343 chr16:354374 AXIN1 -0.64 -7.46 -0.42 1.23e-12 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2688608 0.592 rs10824031 chr10:75509273 C/T cg23231163 chr10:75533350 FUT11 -0.38 -5.85 -0.34 1.42e-8 Inflammatory bowel disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22505778 chr3:113822317 NA -0.45 -6.01 -0.35 6.17e-9 Gut microbiota (bacterial taxa); CESC cis rs2929278 0.617 rs533143 chr15:44188854 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.44 5.72 0.33 2.87e-8 Schizophrenia; CESC cis rs1003719 0.715 rs8129942 chr21:38552070 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.41 -0.46 2.54e-15 Eye color traits; CESC cis rs8058578 1.000 rs6565201 chr16:30747191 C/T cg00531865 chr16:30841666 NA -0.46 -6.26 -0.36 1.51e-9 Multiple myeloma; CESC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg25072359 chr17:41440525 NA 0.46 6.14 0.35 2.95e-9 Menopause (age at onset); CESC cis rs6500602 0.727 rs3761681 chr16:4566857 C/T cg08645402 chr16:4508243 NA 0.55 8.94 0.48 6.61e-17 Schizophrenia; CESC cis rs1124376 0.832 rs6793985 chr3:20136485 T/C cg05072819 chr3:20081367 KAT2B 0.47 5.41 0.32 1.39e-7 Bipolar disorder and schizophrenia; CESC cis rs868036 0.681 rs3784718 chr15:68098004 C/T cg08079166 chr15:68083412 MAP2K5 0.35 5.07 0.3 7.5e-7 Restless legs syndrome; CESC cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.8 0.48 1.82e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg03647317 chr4:187891568 NA -0.39 -5.76 -0.33 2.34e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs11690935 0.959 rs10204502 chr2:172588866 C/G cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.97 -0.68 4e-37 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17379558 chr17:41322482 NBR1 -0.6 -7.32 -0.41 2.88e-12 Gut microbiome composition (summer); CESC trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg03929089 chr4:120376271 NA -0.91 -15.43 -0.69 9.49e-39 Height; CESC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg17143192 chr8:8559678 CLDN23 0.77 8.74 0.47 2.64e-16 Obesity-related traits; CESC cis rs1707322 1.000 rs11211236 chr1:46443767 C/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9583531 0.689 rs9515273 chr13:111383427 G/C cg24331049 chr13:111365604 ING1 0.78 10.45 0.54 1.26e-21 Coronary artery disease; CESC cis rs17433780 0.523 rs6701673 chr1:89525812 C/G cg09516651 chr1:89888402 LOC400759 0.72 10.78 0.55 1.07e-22 Carotid intima media thickness; CESC cis rs10489202 1.000 rs1846416 chr1:167905411 G/A cg24449463 chr1:168025552 DCAF6 -0.46 -5.27 -0.31 2.87e-7 Schizophrenia; CESC cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg10556349 chr10:835070 NA 0.62 5.93 0.34 9.61e-9 Eosinophil percentage of granulocytes; CESC cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg06027949 chr8:82754900 SNX16 -0.43 -5.22 -0.31 3.66e-7 Diastolic blood pressure; CESC cis rs11997175 0.646 rs4733177 chr8:33691754 A/G ch.8.33884649F chr8:33765107 NA 0.56 7.33 0.41 2.73e-12 Body mass index; CESC cis rs4666360 1.000 rs4666361 chr2:20336215 G/C cg23291376 chr2:20336282 NA -0.36 -6.07 -0.35 4.5e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel); CESC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg02931644 chr1:25747376 RHCE 0.4 6.67 0.38 1.45e-10 Erythrocyte sedimentation rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20769334 chr22:50913335 SBF1 0.55 6.8 0.39 6.98e-11 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg13206674 chr6:150067644 NUP43 0.44 6.35 0.36 9.51e-10 Lung cancer; CESC cis rs796364 0.806 rs203767 chr2:200902411 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.83 -7.74 -0.43 2.09e-13 Schizophrenia; CESC cis rs4072980 0.524 rs28442147 chr1:38395410 T/A cg04673462 chr1:38461896 NA 0.36 5.21 0.31 3.72e-7 Coronary artery disease; CESC cis rs7408868 1.000 rs7408868 chr19:15285679 G/C cg14696996 chr19:15285081 NOTCH3 1.04 11.2 0.57 4.4e-24 Pulse pressure; CESC cis rs34779708 0.966 rs35079558 chr10:35479886 A/G cg03585969 chr10:35415529 CREM 0.74 9.5 0.5 1.28e-18 Inflammatory bowel disease;Crohn's disease; CESC cis rs8180040 0.764 rs13061071 chr3:47138708 G/A cg27129171 chr3:47204927 SETD2 0.7 10.54 0.54 6.41e-22 Colorectal cancer; CESC cis rs8040855 0.627 rs17540307 chr15:85633845 A/G cg08123816 chr15:85640762 PDE8A -0.4 -5.89 -0.34 1.18e-8 Bulimia nervosa; CESC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg12756686 chr19:29218302 NA 0.52 6.87 0.39 4.69e-11 Methadone dose in opioid dependence; CESC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg10295955 chr4:187884368 NA 0.97 17.32 0.73 1.78e-45 Lobe attachment (rater-scored or self-reported); CESC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg15225532 chr3:44803084 KIF15;KIAA1143 0.44 5.75 0.33 2.42e-8 Depressive symptoms; CESC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -12.98 -0.62 3.88e-30 Developmental language disorder (linguistic errors); CESC cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg17211192 chr8:82754475 SNX16 -0.67 -8.05 -0.44 2.84e-14 Diastolic blood pressure; CESC cis rs7223966 1.000 rs8064261 chr17:61705212 G/A cg11494091 chr17:61959527 GH2 0.38 5.09 0.3 6.73e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4594175 0.926 rs11851960 chr14:51598610 A/G cg23942311 chr14:51606299 NA 0.4 5.94 0.34 9.07e-9 Cancer; CESC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg26314531 chr2:26401878 FAM59B -0.62 -6.87 -0.39 4.62e-11 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs12600051 chr16:89992072 G/T cg14709524 chr16:89940631 TCF25 0.85 6.04 0.35 5.29e-9 Skin colour saturation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07758428 chr11:68193549 LRP5 0.47 6.37 0.36 8.12e-10 Fibrinogen levels; CESC cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg06484146 chr7:12443880 VWDE -0.78 -9.1 -0.49 2.28e-17 Coronary artery disease; CESC cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg26597838 chr10:835615 NA 0.7 6.53 0.37 3.31e-10 Eosinophil percentage of granulocytes; CESC cis rs6456156 0.565 rs2181058 chr6:167465330 A/T cg07741184 chr6:167504864 NA 0.35 6.08 0.35 4.1e-9 Primary biliary cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08597319 chr8:103876573 AZIN1 0.66 7.76 0.43 1.85e-13 Gut microbiome composition (summer); CESC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg00310523 chr12:86230176 RASSF9 -0.34 -5.45 -0.32 1.17e-7 Major depressive disorder; CESC cis rs7818688 0.697 rs10504939 chr8:95983354 C/G cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs4689388 0.856 rs3200 chr4:6304878 C/T cg00701064 chr4:6280414 WFS1 0.69 11.71 0.58 8.28e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs662064 0.962 rs622623 chr1:10555257 C/T cg20482658 chr1:10539492 PEX14 -0.35 -6.92 -0.39 3.39e-11 Asthma; CESC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg02951883 chr7:2050386 MAD1L1 -0.46 -5.98 -0.34 7.07e-9 Bipolar disorder and schizophrenia; CESC cis rs10197940 0.624 rs17270233 chr2:152372420 A/G cg06191203 chr2:152266755 RIF1 -0.45 -5.15 -0.3 5.05e-7 Lung cancer; CESC cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg10150615 chr22:24372951 LOC391322 -0.47 -6.21 -0.36 2.07e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs10489896 0.541 rs66638830 chr1:234591064 T/G cg10395685 chr11:86085715 CCDC81 -0.43 -6.15 -0.35 2.9e-9 Cognitive test performance; CESC cis rs2635047 0.811 rs10502880 chr18:44770746 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.46 6.05 0.35 4.8e-9 Educational attainment; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14666473 chr12:27091463 FGFR1OP2;C12orf11 0.41 6.32 0.36 1.08e-9 Gut microbiota (bacterial taxa); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11142944 chr22:35653622 HMGXB4 -0.48 -6.62 -0.38 2.03e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03757398 chr1:28920491 RAB42 -0.54 -6.79 -0.38 7.28e-11 Gut microbiome composition (summer); CESC cis rs7605827 0.930 rs6431699 chr2:15540281 A/G cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs10242455 0.717 rs2687133 chr7:99332083 C/T cg07715041 chr7:99302981 CYP3A7 -0.49 -5.86 -0.34 1.34e-8 Blood metabolite levels; CESC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg11764359 chr7:65958608 NA -0.93 -13.63 -0.64 2.02e-32 Aortic root size; CESC cis rs73036520 0.560 rs346750 chr19:45737218 G/T cg01416317 chr19:45737208 EXOC3L2 -0.5 -8.22 -0.45 9.21e-15 Monocyte percentage of white cells; CESC cis rs67072384 1.000 rs72964185 chr11:72443177 G/A cg04827223 chr11:72435913 ARAP1 -0.65 -5.96 -0.34 7.94e-9 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.26 0.31 3.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg22143856 chr6:28129313 ZNF389 0.44 5.49 0.32 9.24e-8 Parkinson's disease; CESC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.84e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2243480 1.000 rs35820085 chr7:65442758 C/T cg13147721 chr7:65941812 NA -0.9 -8.65 -0.47 4.98e-16 Diabetic kidney disease; CESC cis rs6568686 0.577 rs174400 chr6:111922979 A/G cg22127309 chr6:111907043 TRAF3IP2 0.55 5.25 0.31 3.18e-7 Depressive and manic episodes in bipolar disorder;Depressive episodes in bipolar disorder; CESC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg01570182 chr17:44337453 NA 0.67 9.05 0.49 3.12e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12579753 0.810 rs10862355 chr12:82162698 C/T cg24719984 chr12:82153464 PPFIA2 -0.33 -5.22 -0.31 3.55e-7 Resting heart rate; CESC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg01416388 chr22:39784598 NA -0.57 -7.1 -0.4 1.14e-11 Intelligence (multi-trait analysis); CESC cis rs4727027 0.835 rs11767810 chr7:148774433 T/A cg23583168 chr7:148888333 NA -0.78 -11.73 -0.58 7.14e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25887236 chr18:74844781 MBP 0.52 6.17 0.35 2.49e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05492845 chr11:64002298 VEGFB 0.51 6.29 0.36 1.3e-9 Gut microbiome composition (summer); CESC cis rs8020095 0.528 rs8004488 chr14:67667402 C/G cg19548862 chr14:67692701 FAM71D 0.45 5.58 0.32 6.05e-8 Depression (quantitative trait); CESC cis rs854765 0.647 rs721669 chr17:18005073 A/G cg04398451 chr17:18023971 MYO15A -0.76 -11.07 -0.56 1.15e-23 Total body bone mineral density; CESC cis rs7666738 0.618 rs10856932 chr4:98819992 C/T cg17366294 chr4:99064904 C4orf37 0.55 7.51 0.42 9.06e-13 Colonoscopy-negative controls vs population controls; CESC cis rs7607369 0.536 rs6436090 chr2:219669002 A/G cg02176678 chr2:219576539 TTLL4 -0.36 -6.37 -0.36 8.16e-10 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs6088590 0.561 rs6059926 chr20:33164804 C/T cg08999081 chr20:33150536 PIGU 0.69 12.25 0.6 1.2100000000000001e-27 Coronary artery disease; CESC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg05564831 chr3:52568323 NT5DC2 0.43 6.65 0.38 1.71e-10 Bipolar disorder; CESC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg18252515 chr7:66147081 NA 0.39 5.26 0.31 2.97e-7 Aortic root size; CESC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg26343298 chr8:95960752 TP53INP1 0.36 5.98 0.34 7.06e-9 Type 2 diabetes; CESC cis rs8014204 0.836 rs12888998 chr14:75292662 G/T cg08847533 chr14:75593920 NEK9 0.46 5.88 0.34 1.23e-8 Caffeine consumption; CESC cis rs921968 0.643 rs832799 chr2:219490111 C/A cg02176678 chr2:219576539 TTLL4 0.37 6.33 0.36 1.07e-9 Mean corpuscular hemoglobin concentration; CESC trans rs1814175 0.645 rs28538913 chr11:50040718 C/T cg03929089 chr4:120376271 NA -0.91 -14.92 -0.68 5.78e-37 Height; CESC cis rs711245 0.573 rs11899523 chr2:36800918 T/C cg15105969 chr2:36825350 FEZ2 0.46 5.19 0.3 4.27e-7 Height; CESC cis rs8072100 0.905 rs9895274 chr17:45539117 C/T cg08085267 chr17:45401833 C17orf57 -0.53 -7.22 -0.41 5.36e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg23711669 chr6:146136114 FBXO30 -0.97 -14.96 -0.68 4.14e-37 Lobe attachment (rater-scored or self-reported); CESC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg01341218 chr17:43662625 NA 0.92 11.17 0.57 5.26e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10870270 1.000 rs10870232 chr10:133738537 T/G cg08754478 chr10:133766260 PPP2R2D -0.61 -7.97 -0.44 4.75e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs9929218 0.954 rs9925923 chr16:68819614 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -8.6 -0.47 6.87e-16 Colorectal cancer; CESC cis rs7847628 0.550 rs12343516 chr9:123603469 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.93 17.08 0.72 1.34e-44 Birth weight; CESC cis rs1153858 0.723 rs1719238 chr15:45594766 C/T cg21132104 chr15:45694354 SPATA5L1 -0.8 -10.19 -0.53 8.67e-21 Homoarginine levels; CESC trans rs2797160 0.967 rs1343120 chr6:125992810 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.01 -0.35 6.16e-9 Endometrial cancer; CESC cis rs9611565 0.643 rs202634 chr22:41809623 A/G cg17376030 chr22:41985996 PMM1 -0.68 -7.16 -0.4 7.99e-12 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07012189 chr14:93408043 ITPK1 -0.52 -6.0 -0.35 6.45e-9 Gut microbiome composition (summer); CESC cis rs9926296 0.656 rs2376884 chr16:89826922 C/T cg04287289 chr16:89883240 FANCA 0.57 7.62 0.42 4.55e-13 Vitiligo; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg01509141 chr13:44453359 CCDC122;C13orf31 -0.4 -6.26 -0.36 1.54e-9 Breast cancer; CESC cis rs208346 1.000 rs208346 chr7:2799686 G/T cg18446336 chr7:2847575 GNA12 0.41 7.08 0.4 1.26e-11 Loneliness (linear analysis); CESC cis rs57221529 0.664 rs72704802 chr5:554211 C/T cg16447950 chr5:562315 NA -0.8 -7.49 -0.42 1.01e-12 Lung disease severity in cystic fibrosis; CESC cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg24531977 chr5:56204891 C5orf35 0.42 5.47 0.32 1.06e-7 Coronary artery disease; CESC cis rs2985684 0.948 rs2985685 chr14:50101370 G/A cg15316458 chr14:50087796 RPL36AL;MGAT2 0.45 5.15 0.3 4.99e-7 Carotid intima media thickness; CESC cis rs1322639 1.000 rs9689079 chr6:169587148 A/G cg03254818 chr6:169586852 NA -0.53 -7.27 -0.41 4.15e-12 Pulse pressure; CESC cis rs7216064 0.953 rs4791048 chr17:65848994 G/A cg07042672 chr17:66097459 LOC651250 -0.62 -7.37 -0.41 2.23e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs854765 0.552 rs6502624 chr17:17847936 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs7520050 0.807 rs3013594 chr1:46138000 T/C cg03146154 chr1:46216737 IPP 0.52 6.76 0.38 8.52e-11 Red blood cell count;Reticulocyte count; CESC cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg04317338 chr11:64019027 PLCB3 0.47 5.62 0.33 4.95e-8 Platelet count; CESC cis rs4253772 0.513 rs9306512 chr22:46716603 T/C cg18190219 chr22:46762943 CELSR1 -0.44 -5.8 -0.34 1.84e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9814567 1.000 rs9869981 chr3:134248801 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.08 -0.35 4.19e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs10242455 0.702 rs917152 chr7:99004497 T/C cg25640893 chr7:99214727 ZNF498 1.03 6.4 0.37 7.13e-10 Blood metabolite levels; CESC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg18876405 chr7:65276391 NA 0.53 7.28 0.41 3.9e-12 Aortic root size; CESC cis rs7833790 0.777 rs1005850 chr8:82692255 G/A cg02079420 chr8:82753780 SNX16 0.5 6.87 0.39 4.45e-11 Diastolic blood pressure; CESC cis rs2204008 0.640 rs2320744 chr12:38162389 A/G cg13010199 chr12:38710504 ALG10B 0.55 6.84 0.39 5.39e-11 Bladder cancer; CESC trans rs11039798 1.000 rs10769383 chr11:48592510 C/G cg15704280 chr7:45808275 SEPT13 0.7 6.68 0.38 1.41e-10 Axial length; CESC cis rs62432291 0.681 rs365045 chr6:159632250 A/G cg14500486 chr6:159655392 FNDC1 0.52 5.67 0.33 3.65e-8 Joint mobility (Beighton score); CESC cis rs791888 1.000 rs2762521 chr10:89414923 T/A cg13926569 chr10:89418898 PAPSS2 -0.44 -6.28 -0.36 1.36e-9 Magnesium levels; CESC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg00166722 chr3:10149974 C3orf24 0.47 5.86 0.34 1.38e-8 Alzheimer's disease; CESC cis rs6815814 0.851 rs11466645 chr4:38778203 A/T cg02016764 chr4:38805732 TLR1 -0.68 -8.12 -0.45 1.73e-14 Breast cancer; CESC cis rs35110281 0.641 rs9983670 chr21:45083425 A/G cg21573476 chr21:45109991 RRP1B -0.59 -8.81 -0.48 1.63e-16 Mean corpuscular volume; CESC cis rs6740322 0.748 rs6732337 chr2:43462822 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.76 8.71 0.47 3.24e-16 Coronary artery disease; CESC cis rs6964587 0.692 rs10271430 chr7:91710466 G/C cg17063962 chr7:91808500 NA 0.45 6.46 0.37 5.12e-10 Breast cancer; CESC cis rs666930 0.519 rs477992 chr1:120257576 A/G cg19096424 chr1:120255104 PHGDH 0.69 8.71 0.47 3.35e-16 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14156148 chr15:102502487 WASH3P -0.59 -6.75 -0.38 9.55e-11 Gut microbiome composition (summer); CESC cis rs4919694 1.000 rs12245779 chr10:104645944 C/A cg04362960 chr10:104952993 NT5C2 0.78 6.59 0.38 2.31e-10 Arsenic metabolism; CESC cis rs2204008 0.818 rs7313608 chr12:38383428 C/A cg13010199 chr12:38710504 ALG10B -0.44 -5.7 -0.33 3.24e-8 Bladder cancer; CESC cis rs73206853 0.764 rs7312139 chr12:110985442 C/A cg12870014 chr12:110450643 ANKRD13A 0.67 5.85 0.34 1.42e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05610740 chr12:96794311 CDK17 0.58 6.2 0.36 2.1e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07777156 chr17:22022000 NA -0.54 -6.07 -0.35 4.47e-9 Gut microbiome composition (summer); CESC cis rs2625529 0.652 rs2929513 chr15:72229180 G/A cg16672083 chr15:72433130 SENP8 0.4 5.95 0.34 8.49e-9 Red blood cell count; CESC cis rs208520 0.954 rs12190073 chr6:66983740 T/C cg07460842 chr6:66804631 NA 0.88 10.14 0.53 1.22e-20 Exhaled nitric oxide output; CESC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs11209002 0.567 rs2755268 chr1:67539881 T/C cg02640540 chr1:67518911 SLC35D1 0.47 5.39 0.31 1.52e-7 Crohn's disease; CESC cis rs854765 0.583 rs4925125 chr17:17794444 T/C cg04398451 chr17:18023971 MYO15A 0.69 10.07 0.53 2.12e-20 Total body bone mineral density; CESC cis rs9359856 0.564 rs11962292 chr6:90476788 C/T cg13799429 chr6:90582589 CASP8AP2 -0.64 -6.06 -0.35 4.56e-9 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27276079 chr15:42211520 EHD4 -0.61 -6.58 -0.37 2.5e-10 Gut microbiome composition (summer); CESC cis rs6032067 0.929 rs13043296 chr20:43805688 T/C cg10761708 chr20:43804764 PI3 0.53 6.33 0.36 1.04e-9 Blood protein levels; CESC trans rs1545843 0.593 rs7310247 chr12:84799396 C/T cg03015433 chr16:56623111 MT3 -0.34 -6.14 -0.35 3.04e-9 Major depressive disorder; CESC cis rs2204008 0.542 rs34770471 chr12:38009613 C/T cg13010199 chr12:38710504 ALG10B 0.54 6.71 0.38 1.15e-10 Bladder cancer; CESC trans rs4904167 0.841 rs10149675 chr14:84679322 G/T cg06870609 chr15:89787223 FANCI 0.46 6.01 0.35 6.03e-9 Autism spectrum disorder or schizophrenia; CESC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.2 0.3 3.98e-7 Tonsillectomy; CESC cis rs2180341 0.618 rs4502958 chr6:127593113 G/A cg24812749 chr6:127587940 RNF146 0.59 8.02 0.44 3.42e-14 Breast cancer; CESC cis rs36051895 0.589 rs7848312 chr9:5237442 T/C cg02405213 chr9:5042618 JAK2 -0.56 -6.63 -0.38 1.9e-10 Pediatric autoimmune diseases; CESC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg18876405 chr7:65276391 NA 0.49 5.81 0.34 1.83e-8 Aortic root size; CESC trans rs4670302 1.000 rs4670302 chr2:34068392 A/C cg12382846 chr20:60892121 LAMA5 -0.48 -6.21 -0.36 2e-9 Gut microbiota (beta diversity); CESC cis rs28595532 0.748 rs67928655 chr4:119336525 C/A cg21605333 chr4:119757512 SEC24D 0.95 5.97 0.34 7.39e-9 Cannabis dependence symptom count; CESC cis rs28374715 0.635 rs28557159 chr15:41657353 T/C cg18705301 chr15:41695430 NDUFAF1 -0.8 -12.15 -0.6 2.72e-27 Ulcerative colitis; CESC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.28 -0.36 1.34e-9 Total body bone mineral density; CESC cis rs2274273 0.870 rs13379169 chr14:55741287 C/T cg04306507 chr14:55594613 LGALS3 0.29 5.6 0.33 5.29e-8 Protein biomarker; CESC trans rs4424809 0.614 rs74484132 chr13:85572870 A/G cg05918002 chr17:5019452 ZNF232 -0.63 -6.08 -0.35 4.29e-9 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs748404 0.578 rs478028 chr15:43610772 C/T cg24053811 chr14:70265306 SLC10A1 0.41 6.0 0.35 6.61e-9 Lung cancer; CESC cis rs7000551 0.505 rs73227818 chr8:22243325 T/C cg12081754 chr8:22256438 SLC39A14 0.84 11.21 0.57 3.99e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.3 -0.5 5.54e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6426558 0.537 rs694740 chr1:227293451 A/G cg10327440 chr1:227177885 CDC42BPA 0.45 5.56 0.32 6.54e-8 Neutrophil percentage of white cells; CESC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg26314531 chr2:26401878 FAM59B -0.62 -7.07 -0.4 1.37e-11 Gut microbiome composition (summer); CESC cis rs10206020 0.921 rs2280127 chr2:1546531 C/T cg01028140 chr2:1542097 TPO -0.48 -6.04 -0.35 5.2e-9 IgG glycosylation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22438603 chr5:127418940 SLC12A2;FLJ33630 0.45 6.18 0.35 2.38e-9 Gut microbiota (bacterial taxa); CESC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg03036452 chr22:46663545 TTC38 0.62 5.22 0.31 3.6e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9811920 0.555 rs68092024 chr3:99691522 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.49 -7.69 -0.43 2.89e-13 Axial length; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01584448 chr16:50099761 HEATR3 0.55 6.52 0.37 3.59e-10 Gut microbiome composition (summer); CESC cis rs6665290 0.669 rs34267809 chr1:227176162 C/G cg10327440 chr1:227177885 CDC42BPA -1.14 -25.45 -0.84 3.87e-73 Myeloid white cell count; CESC cis rs8114671 0.804 rs3803936 chr20:33632775 T/C cg24642439 chr20:33292090 TP53INP2 -0.45 -5.44 -0.32 1.19e-7 Height; CESC cis rs11971779 0.941 rs1127424 chr7:139107660 A/G cg07862535 chr7:139043722 LUC7L2 0.56 5.68 0.33 3.53e-8 Diisocyanate-induced asthma; CESC cis rs9300255 0.739 rs1969354 chr12:123741776 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.63 0.47 5.59e-16 Neutrophil percentage of white cells; CESC cis rs2050392 0.630 rs303427 chr10:30739780 G/A cg25182066 chr10:30743637 MAP3K8 -0.47 -6.61 -0.38 2.11e-10 Inflammatory bowel disease; CESC cis rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07157506 chr18:12883603 PTPN2 -0.47 -6.31 -0.36 1.17e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11098499 0.954 rs12499324 chr4:120393786 C/T cg24375607 chr4:120327624 NA 0.46 5.7 0.33 3.25e-8 Corneal astigmatism; CESC cis rs7089973 0.872 rs11818115 chr10:116634891 G/A cg23260525 chr10:116636907 FAM160B1 0.37 6.15 0.35 2.84e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9399137 0.507 rs7745289 chr6:135380327 A/G cg24558204 chr6:135376177 HBS1L 0.69 9.52 0.5 1.12e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs4699052 0.893 rs4699058 chr4:104171321 T/A cg16532752 chr4:104119610 CENPE -0.43 -5.89 -0.34 1.15e-8 Testicular germ cell tumor; CESC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.56 -0.37 2.74e-10 Life satisfaction; CESC cis rs763121 0.853 rs2413544 chr22:39059404 A/C cg06022373 chr22:39101656 GTPBP1 0.88 13.88 0.65 2.66e-33 Menopause (age at onset); CESC cis rs2361718 0.500 rs4889818 chr17:78085228 A/G cg23534315 chr17:78082725 GAA 0.39 5.39 0.31 1.55e-7 Yeast infection; CESC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.35 0.81 6.51e-63 Prudent dietary pattern; CESC cis rs4268898 0.662 rs72793208 chr2:24510284 C/T cg08917208 chr2:24149416 ATAD2B 0.53 5.32 0.31 2.24e-7 Asthma; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02501984 chr12:133263946 POLE;PXMP2 -0.47 -6.23 -0.36 1.87e-9 Ulcerative colitis; CESC cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg10523679 chr1:76189770 ACADM -0.63 -6.33 -0.36 1.02e-9 Blood metabolite levels;Acylcarnitine levels; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg25722142 chr6:139695762 CITED2 0.46 6.22 0.36 1.96e-9 Weight; CESC cis rs4692589 1.000 rs4321597 chr4:170934424 C/T cg19918862 chr4:170955249 NA 0.37 5.83 0.34 1.59e-8 Anxiety disorder; CESC cis rs60871478 1.000 rs4719314 chr7:822523 A/G cg00475322 chr7:917719 C7orf20 -0.47 -5.08 -0.3 7.01e-7 Cerebrospinal P-tau181p levels; CESC cis rs4969178 0.965 rs8077859 chr17:76386335 C/T cg20026190 chr17:76395443 PGS1 0.44 6.81 0.39 6.46e-11 HDL cholesterol levels; CESC cis rs3820068 0.705 rs4646075 chr1:15827461 T/C cg17385448 chr1:15911702 AGMAT 0.39 6.18 0.35 2.44e-9 Systolic blood pressure; CESC cis rs4595586 0.525 rs35046524 chr12:39414535 A/G cg13010199 chr12:38710504 ALG10B 0.43 5.33 0.31 2.13e-7 Morning vs. evening chronotype; CESC cis rs67460515 0.892 rs34016896 chr3:160992864 C/T cg03342759 chr3:160939853 NMD3 -0.53 -7.28 -0.41 3.89e-12 Parkinson's disease; CESC cis rs4253772 0.550 rs6007779 chr22:46678615 A/C cg24881330 chr22:46731750 TRMU 0.92 10.31 0.53 3.68e-21 LDL cholesterol;Cholesterol, total; CESC cis rs1348850 0.846 rs4893962 chr2:178421106 A/G cg23306229 chr2:178417860 TTC30B 0.58 7.45 0.42 1.3e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs34734847 1.000 rs3752531 chr12:121157851 A/G cg21892295 chr12:121157589 UNC119B -0.41 -6.51 -0.37 3.79e-10 Mean corpuscular volume; CESC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.44 0.32 1.2e-7 Menopause (age at onset); CESC cis rs6541297 0.703 rs585361 chr1:230314954 G/A cg20703242 chr1:230279135 GALNT2 -0.43 -5.62 -0.33 4.84e-8 Coronary artery disease; CESC cis rs4654899 0.865 rs4654891 chr1:21286391 T/C cg05370193 chr1:21551575 ECE1 0.41 6.2 0.36 2.21e-9 Superior frontal gyrus grey matter volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00804338 chr13:114239234 TFDP1 0.57 7.33 0.41 2.82e-12 Gut microbiome composition (summer); CESC cis rs2251381 0.778 rs722013 chr21:30549245 G/T cg08807101 chr21:30365312 RNF160 0.67 8.23 0.45 8.77e-15 Selective IgA deficiency; CESC cis rs10851478 0.872 rs1395901 chr15:49849674 C/T cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.18 0.3 4.41e-7 Oral cavity cancer; CESC cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.42 0.32 1.34e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1348850 0.750 rs55792594 chr2:178496468 C/T cg23306229 chr2:178417860 TTC30B 0.55 7.02 0.4 1.91e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2519796 0.531 rs2519802 chr9:136805853 A/G cg13751417 chr9:136814406 VAV2 -0.44 -5.85 -0.34 1.43e-8 Hematocrit;Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05110787 chr11:61447839 DAGLA 0.57 6.83 0.39 5.68e-11 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25697769 chr22:39097335 JOSD1 -0.49 -6.4 -0.37 7.15e-10 Ulcerative colitis; CESC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg04369109 chr6:150039330 LATS1 -0.48 -6.6 -0.38 2.26e-10 Lung cancer; CESC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg18404041 chr3:52824283 ITIH1 -0.35 -5.92 -0.34 9.85e-9 Bipolar disorder; CESC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 10.62 0.55 3.59e-22 Platelet count; CESC cis rs1008375 1.000 rs10939742 chr4:17659936 G/T cg02297831 chr4:17616191 MED28 0.54 6.79 0.39 7.22e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg19592336 chr6:28129416 ZNF389 0.62 8.12 0.45 1.77e-14 Depression; CESC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9911578 1.000 rs9892795 chr17:57023054 G/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.41e-11 Intelligence (multi-trait analysis); CESC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg08027265 chr7:2291960 NA -0.4 -5.97 -0.34 7.43e-9 Bipolar disorder and schizophrenia; CESC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.61 8.07 0.44 2.51e-14 Menopause (age at onset); CESC trans rs1814175 0.616 rs847641 chr11:49919261 T/C cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs2274273 0.686 rs66782529 chr14:55587867 C/T cg04306507 chr14:55594613 LGALS3 0.33 5.86 0.34 1.37e-8 Protein biomarker; CESC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg11494091 chr17:61959527 GH2 0.73 12.55 0.61 1.13e-28 Prudent dietary pattern; CESC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.25 0.53 5.63e-21 Prudent dietary pattern; CESC cis rs2573652 1.000 rs2581362 chr15:100513524 T/C cg09918751 chr15:100517450 ADAMTS17 -0.39 -7.61 -0.42 4.79e-13 Height; CESC cis rs4466137 1.000 rs1154888 chr5:82977410 C/A cg16102102 chr5:83017553 HAPLN1 -0.42 -6.27 -0.36 1.49e-9 Prostate cancer; CESC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg09455208 chr3:40491958 NA 0.49 8.24 0.45 7.86e-15 Renal cell carcinoma; CESC cis rs9970334 0.596 rs709209 chr1:6278414 A/G cg02892189 chr1:6321676 GPR153 -0.41 -6.1 -0.35 3.74e-9 Resting heart rate; CESC cis rs1879734 0.731 rs12082358 chr1:54156624 A/C cg23596471 chr1:54105337 GLIS1 0.34 5.47 0.32 1.03e-7 Mitral valve prolapse; CESC cis rs1030877 0.960 rs3792047 chr2:105901553 A/G cg02079111 chr2:105885981 TGFBRAP1 -0.66 -10.14 -0.53 1.28e-20 Obesity-related traits; CESC cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.82 -12.11 -0.6 3.74e-27 Systemic lupus erythematosus; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18816107 chr1:151227233 PSMD4 -0.42 -6.08 -0.35 4.21e-9 Gambling; CESC cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg04450456 chr4:17643702 FAM184B 0.36 5.16 0.3 4.93e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09544279 chr5:179921349 CNOT6 0.57 6.88 0.39 4.24e-11 Gut microbiome composition (summer); CESC cis rs921968 0.541 rs526897 chr2:219433597 C/T cg02176678 chr2:219576539 TTLL4 0.52 8.72 0.47 3.12e-16 Mean corpuscular hemoglobin concentration; CESC cis rs8020095 0.528 rs2296561 chr14:67849139 A/T cg19548862 chr14:67692701 FAM71D -0.45 -5.3 -0.31 2.41e-7 Depression (quantitative trait); CESC cis rs12476592 0.602 rs6732791 chr2:63788901 C/A cg17519650 chr2:63277830 OTX1 -0.48 -5.45 -0.32 1.15e-7 Childhood ear infection; CESC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg04414720 chr1:150670196 GOLPH3L 0.51 6.78 0.38 7.88e-11 Melanoma; CESC cis rs4889609 0.834 rs72785520 chr16:31070778 C/T cg02466173 chr16:30829666 NA -0.42 -7.33 -0.41 2.8e-12 Response to metformin (IC50); CESC cis rs11227306 0.934 rs2303384 chr11:65640204 C/T cg00576331 chr11:65640516 EFEMP2 0.48 6.18 0.36 2.38e-9 DNA methylation (variation); CESC cis rs861020 0.606 rs689210 chr1:210013723 A/C cg05527609 chr1:210001259 C1orf107 0.75 10.05 0.53 2.48e-20 Orofacial clefts; CESC cis rs709400 0.894 rs61996721 chr14:104061352 G/A cg24130564 chr14:104152367 KLC1 -0.42 -5.07 -0.3 7.49e-7 Body mass index; CESC cis rs11155671 0.530 rs7768626 chr6:150207962 G/T cg09699651 chr6:150184138 LRP11 0.55 7.65 0.43 3.82e-13 Testicular germ cell tumor; CESC cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg18402987 chr7:1209562 NA 0.52 6.21 0.36 2.06e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11098499 0.954 rs6849561 chr4:120409694 C/G cg09307838 chr4:120376055 NA -0.93 -13.17 -0.63 8.4e-31 Corneal astigmatism; CESC trans rs1814175 0.715 rs10839409 chr11:49884647 G/T cg03929089 chr4:120376271 NA -0.91 -15.47 -0.69 6.82e-39 Height; CESC cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg14582100 chr15:45693742 SPATA5L1 -0.42 -6.05 -0.35 4.98e-9 Homoarginine levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg27006547 chr11:62606509 WDR74 0.44 6.23 0.36 1.84e-9 Systemic lupus erythematosus; CESC cis rs904251 0.861 rs1757183 chr6:37484790 C/T cg01843034 chr6:37503916 NA 0.28 5.36 0.31 1.85e-7 Cognitive performance; CESC trans rs11039798 0.588 rs7946443 chr11:48545504 G/A cg15704280 chr7:45808275 SEPT13 0.66 6.67 0.38 1.46e-10 Axial length; CESC cis rs3784262 1.000 rs4646622 chr15:58257199 A/G cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.07 -0.3 7.58e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs3796619 1.000 rs1453605 chr4:1075771 C/T cg27284194 chr4:1044797 NA 0.36 5.5 0.32 8.88e-8 Recombination rate (males); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14455541 chr20:49203350 FAM65C -0.58 -6.63 -0.38 1.86e-10 Gut microbiome composition (summer); CESC cis rs7684253 0.587 rs4339274 chr4:57747634 A/G cg21154227 chr4:57904332 IGFBP7 -0.35 -5.16 -0.3 4.83e-7 Migraine; CESC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.69 0.38 1.3100000000000001e-10 Bipolar disorder; CESC cis rs7095944 0.584 rs4962691 chr10:126424137 C/T cg08799069 chr10:126477246 METTL10 -0.4 -5.89 -0.34 1.19e-8 Asthma; CESC cis rs4065321 0.609 rs8075668 chr17:38137623 C/T cg17467752 chr17:38218738 THRA -0.5 -7.19 -0.4 6.59e-12 White blood cell count (basophil);White blood cell count; CESC cis rs72945132 0.941 rs66803755 chr11:70117473 G/A cg14191688 chr11:70257035 CTTN 0.41 5.15 0.3 5.15e-7 Coronary artery disease; CESC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg07677032 chr17:61819896 STRADA 0.47 6.18 0.35 2.41e-9 Prudent dietary pattern; CESC cis rs9549328 0.800 rs9549619 chr13:113632620 C/G cg22951483 chr13:113628068 MCF2L -0.35 -5.05 -0.3 8.1e-7 Systolic blood pressure; CESC cis rs7249142 0.573 rs2238668 chr19:19282597 A/G cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.29 5.21 0.3 3.75e-7 IgG glycosylation; CESC cis rs1729951 0.546 rs835632 chr3:136676525 A/T cg03617693 chr3:136751559 NA 0.37 5.26 0.31 2.9e-7 Neuroticism; CESC cis rs425277 0.583 rs925905 chr1:2044037 T/C cg24578937 chr1:2090814 PRKCZ -0.32 -5.51 -0.32 8.51e-8 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02203922 chr6:657011 HUS1B;EXOC2 0.49 6.35 0.36 9.15e-10 Fibrinogen levels; CESC cis rs2243480 1.000 rs34577383 chr7:65385726 C/T cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC cis rs12497850 0.931 rs11705888 chr3:48817289 T/C cg06212747 chr3:49208901 KLHDC8B 0.64 8.49 0.46 1.49e-15 Parkinson's disease; CESC cis rs17428076 0.793 rs72881938 chr2:172628752 C/G cg13550731 chr2:172543902 DYNC1I2 0.47 5.25 0.31 3.08e-7 Myopia; CESC cis rs12291225 0.679 rs11023172 chr11:14295367 C/G cg19336497 chr11:14380999 RRAS2 -0.37 -5.27 -0.31 2.76e-7 Sense of smell; CESC cis rs965469 0.843 rs6051698 chr20:3248983 T/C cg25506879 chr20:3388711 C20orf194 -0.51 -5.6 -0.33 5.48e-8 IFN-related cytopenia; CESC cis rs11696501 0.688 rs6073854 chr20:44309605 A/G cg11783356 chr20:44313418 WFDC10B -0.32 -5.12 -0.3 5.77e-7 Brain structure; CESC cis rs1005277 0.577 rs4934906 chr10:38015028 C/T cg25427524 chr10:38739819 LOC399744 -0.62 -8.7 -0.47 3.56e-16 Extrinsic epigenetic age acceleration; CESC cis rs208520 0.690 rs12192710 chr6:66718137 C/T cg07460842 chr6:66804631 NA 0.95 12.62 0.61 6.69e-29 Exhaled nitric oxide output; CESC cis rs7824557 0.505 rs2736313 chr8:11086942 C/T cg14752069 chr8:11977206 FAM66D 0.32 5.36 0.31 1.82e-7 Retinal vascular caliber; CESC cis rs17376456 1.000 rs9968691 chr5:93509756 C/G cg21475434 chr5:93447410 FAM172A 0.88 7.77 0.43 1.71e-13 Diabetic retinopathy; CESC cis rs4319547 0.915 rs1473553 chr12:122985057 G/T cg05707623 chr12:122985044 ZCCHC8 -0.66 -7.6 -0.42 5.09e-13 Body mass index; CESC cis rs11098499 0.863 rs1552095 chr4:120460306 A/G cg24375607 chr4:120327624 NA 0.46 5.43 0.32 1.29e-7 Corneal astigmatism; CESC cis rs3892630 0.817 rs12609866 chr19:33184412 C/T cg22980127 chr19:33182716 NUDT19 1.02 11.67 0.58 1.15e-25 Red blood cell traits; CESC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg04025307 chr7:1156635 C7orf50 0.4 6.45 0.37 5.38e-10 Longevity;Endometriosis; CESC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg08859206 chr1:53392774 SCP2 0.54 7.13 0.4 9.54e-12 Monocyte count; CESC cis rs7772486 0.875 rs10457793 chr6:146415403 A/G cg23711669 chr6:146136114 FBXO30 0.86 12.72 0.62 2.98e-29 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04429812 chr17:37814043 STARD3 0.52 6.9 0.39 3.81e-11 Fibrinogen levels; CESC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs643506 0.874 rs673679 chr11:111686800 C/T cg17089665 chr11:111648010 NA -0.36 -5.29 -0.31 2.53e-7 Breast cancer; CESC cis rs6430585 0.527 rs62168830 chr2:136443900 A/T cg07169764 chr2:136633963 MCM6 1.09 12.56 0.61 1.07e-28 Corneal structure; CESC cis rs12541635 0.677 rs55639043 chr8:107055993 C/T cg10147462 chr8:107024639 NA 0.48 7.18 0.4 6.9e-12 Age of smoking initiation; CESC cis rs10089 1.000 rs3805606 chr5:127470813 A/C cg19767477 chr5:127420684 SLC12A2 0.42 5.64 0.33 4.32e-8 Ileal carcinoids; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05784314 chr1:153747728 SLC27A3 0.61 6.6 0.38 2.28e-10 Gut microbiome composition (summer); CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg24739457 chr1:205821442 NA 0.46 6.03 0.35 5.48e-9 Menarche (age at onset); CESC cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg07234876 chr8:600039 NA 0.82 5.79 0.34 1.95e-8 IgG glycosylation; CESC cis rs6032067 0.929 rs13043503 chr20:43805835 T/C cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.5e-8 Blood protein levels; CESC cis rs1348850 0.789 rs13027959 chr2:178275887 G/A cg23306229 chr2:178417860 TTC30B 0.62 8.13 0.45 1.71e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6840258 1.000 rs72667765 chr4:87965942 G/A cg08197287 chr4:87952173 AFF1 -0.39 -5.33 -0.31 2.11e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs9926296 0.581 rs2108838 chr16:89904426 A/G cg27121462 chr16:89883253 FANCA 0.62 7.5 0.42 9.46e-13 Vitiligo; CESC cis rs2840044 0.534 rs167691 chr17:33885826 G/A cg05299278 chr17:33885742 SLFN14 0.42 6.13 0.35 3.14e-9 Response to radiotherapy in cancer (late toxicity); CESC cis rs2952156 0.920 rs903502 chr17:37829604 C/T cg20243544 chr17:37824526 PNMT 0.63 8.15 0.45 1.47e-14 Asthma; CESC cis rs7692995 1.000 rs6842114 chr4:18008199 A/C cg08925142 chr4:18023851 LCORL -0.44 -5.1 -0.3 6.35e-7 Height; CESC cis rs7772486 0.764 rs2265471 chr6:146220250 G/A cg05347473 chr6:146136440 FBXO30 0.53 6.86 0.39 4.96e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg26597838 chr10:835615 NA 1.15 11.56 0.58 2.63e-25 Eosinophil percentage of granulocytes; CESC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg18240062 chr17:79603768 NPLOC4 0.54 7.12 0.4 1.04e-11 Eye color traits; CESC cis rs4523957 0.928 rs375245 chr17:2199754 G/A cg16513277 chr17:2031491 SMG6 0.63 8.49 0.46 1.48e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg19468946 chr17:37922297 IKZF3 0.4 5.22 0.31 3.56e-7 Glomerular filtration rate (creatinine); CESC cis rs116095464 0.558 rs10079760 chr5:230778 A/G cg22857025 chr5:266934 NA -1.26 -18.31 -0.75 5.63e-49 Breast cancer; CESC cis rs6500395 1.000 rs9938308 chr16:48607229 A/G cg04672837 chr16:48644449 N4BP1 0.52 6.51 0.37 3.68e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2070997 0.592 rs7858778 chr9:133679656 A/G cg11464064 chr9:133710261 ABL1 0.58 6.42 0.37 6.27e-10 Response to amphetamines; CESC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.05 0.56 1.38e-23 Alzheimer's disease; CESC cis rs7103648 0.897 rs35032070 chr11:47408592 G/A cg20307385 chr11:47447363 PSMC3 0.94 14.65 0.67 5.08e-36 Diastolic blood pressure;Systolic blood pressure; CESC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg06601766 chr17:61851465 DDX42;CCDC47 0.75 9.45 0.5 1.89e-18 Height; CESC cis rs7917772 0.536 rs12357172 chr10:104388549 C/T cg22532475 chr10:104410764 TRIM8 -0.44 -6.77 -0.38 8.33e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7560272 0.723 rs780391 chr2:73703904 C/T cg20560298 chr2:73613845 ALMS1 0.5 7.15 0.4 8.3e-12 Schizophrenia; CESC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg22823121 chr1:150693482 HORMAD1 -0.41 -6.39 -0.37 7.49e-10 Tonsillectomy; CESC cis rs1385374 0.858 rs11059933 chr12:129303593 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 0.6 5.22 0.31 3.61e-7 Systemic lupus erythematosus; CESC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg24675658 chr1:53192096 ZYG11B -0.52 -6.44 -0.37 5.68e-10 Monocyte count; CESC cis rs9486719 1.000 rs2472882 chr6:96863474 C/T cg06623918 chr6:96969491 KIAA0776 0.82 8.4 0.46 2.72e-15 Migraine;Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01700524 chr14:24803014 ADCY4 -0.48 -6.2 -0.36 2.17e-9 Ulcerative colitis; CESC cis rs1843834 1.000 rs4624372 chr2:225553128 A/G cg22455342 chr2:225449267 CUL3 0.53 6.56 0.37 2.86e-10 IgE levels in asthmatics (D.p. specific); CESC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg23985595 chr17:80112537 CCDC57 -0.4 -6.32 -0.36 1.1e-9 Life satisfaction; CESC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg00149659 chr3:10157352 C3orf10 0.71 8.4 0.46 2.72e-15 Alzheimer's disease; CESC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg10691866 chr7:65817282 TPST1 -0.33 -5.43 -0.32 1.3e-7 Aortic root size; CESC trans rs561341 0.700 rs6505266 chr17:30225813 G/A cg20587970 chr11:113659929 NA -0.6 -7.99 -0.44 4.15e-14 Hip circumference adjusted for BMI; CESC cis rs1559088 0.948 rs12608825 chr19:33581219 C/T cg17764715 chr19:33622953 WDR88 -0.53 -6.91 -0.39 3.66e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1953600 0.870 rs2789695 chr10:81946840 C/T cg00277334 chr10:82204260 NA 0.45 6.28 0.36 1.4e-9 Sarcoidosis; CESC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg14893161 chr1:205819251 PM20D1 0.44 5.83 0.34 1.63e-8 Parkinson's disease; CESC trans rs11098499 0.954 rs2306455 chr4:120421969 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.78 0.51 1.7e-19 Corneal astigmatism; CESC cis rs916888 0.821 rs70602 chr17:44859715 T/C cg14517863 chr17:44321492 NA -0.4 -5.16 -0.3 4.79e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7178572 0.568 rs8037561 chr15:77680462 A/G cg22256960 chr15:77711686 NA -0.54 -6.95 -0.39 2.9e-11 Type 2 diabetes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11239145 chr4:26320844 RBPJ -0.45 -6.01 -0.35 6.18e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7267979 1.000 rs6115159 chr20:25350944 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.23e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg17294928 chr15:75287854 SCAMP5 0.47 6.23 0.36 1.81e-9 Breast cancer; CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg18765753 chr7:1198926 ZFAND2A -0.47 -5.86 -0.34 1.38e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17240275 chr15:75500943 C15orf39 -0.52 -6.03 -0.35 5.34e-9 Gut microbiome composition (summer); CESC cis rs4666360 1.000 rs4666295 chr2:20337144 C/T cg23291376 chr2:20336282 NA 0.36 6.04 0.35 5.14e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel); CESC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg03676636 chr4:99064102 C4orf37 0.37 5.41 0.32 1.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg24308560 chr3:49941425 MST1R 0.63 9.38 0.5 3.2e-18 Intelligence (multi-trait analysis); CESC cis rs9517302 0.847 rs9517297 chr13:99094961 A/C cg22223119 chr13:99095684 FARP1 -0.56 -8.64 -0.47 5.26e-16 Obesity-related traits; CESC cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.89 0.34 1.2e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7582720 1.000 rs4675310 chr2:203880834 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 -0.86 -6.93 -0.39 3.28e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg22535103 chr8:58192502 C8orf71 -0.92 -10.13 -0.53 1.34e-20 Developmental language disorder (linguistic errors); CESC cis rs4589502 0.512 rs7183242 chr15:67096658 A/G cg12317470 chr15:67143691 NA 0.51 6.51 0.37 3.67e-10 Lung cancer (smoking interaction); CESC cis rs11650494 0.710 rs16948078 chr17:47474800 C/T cg08112188 chr17:47440006 ZNF652 -0.77 -5.8 -0.34 1.87e-8 Prostate cancer; CESC cis rs7089973 0.872 rs17092542 chr10:116630289 G/A cg25233709 chr10:116636983 FAM160B1 0.35 5.09 0.3 6.77e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15228606 chr17:1812096 NA -0.52 -7.06 -0.4 1.46e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg15556689 chr8:8085844 FLJ10661 -0.44 -5.38 -0.31 1.6e-7 Mood instability; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10311315 chr2:101889706 SNORD89 0.44 6.24 0.36 1.74e-9 Fibrinogen levels; CESC trans rs724568 0.681 rs4671842 chr2:67945371 T/C cg19718508 chr5:176831858 F12 -0.44 -6.01 -0.35 6.26e-9 Major depressive disorder (broad); CESC cis rs6459788 0.693 rs35146559 chr7:157238557 G/A cg06271696 chr7:157225062 NA -0.39 -5.35 -0.31 1.89e-7 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs11997175 0.624 rs4733179 chr8:33692223 T/G ch.8.33884649F chr8:33765107 NA 0.55 7.18 0.4 6.97e-12 Body mass index; CESC cis rs7223966 1.000 rs9903903 chr17:61762044 A/G cg11494091 chr17:61959527 GH2 0.38 5.35 0.31 1.93e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs8031584 0.918 rs35396566 chr15:31263057 T/C cg08109568 chr15:31115862 NA -0.74 -9.38 -0.5 3.17e-18 Huntington's disease progression; CESC cis rs7208859 0.623 rs9911173 chr17:29154750 C/T cg19761014 chr17:28927070 LRRC37B2 0.72 5.91 0.34 1.03e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs763014 0.898 rs8060585 chr16:635794 C/G cg09781414 chr16:715207 WDR90 -0.33 -5.04 -0.3 8.57e-7 Height; CESC cis rs7264396 0.635 rs6060681 chr20:34506147 A/G cg17201900 chr20:34330562 RBM39 0.48 5.12 0.3 5.97e-7 Total cholesterol levels; CESC cis rs7607369 0.536 rs4674344 chr2:219669875 A/T cg02176678 chr2:219576539 TTLL4 -0.36 -6.22 -0.36 1.94e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.27e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10089 1.000 rs4836363 chr5:127462737 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.07 0.53 2.04e-20 Ileal carcinoids; CESC cis rs1355223 0.902 rs7130325 chr11:34750959 A/G cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.13 -0.35 3.23e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6963495 0.818 rs55740553 chr7:105159551 A/G cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs938554 0.736 rs4475146 chr4:9946656 C/A cg11266682 chr4:10021025 SLC2A9 -0.39 -5.29 -0.31 2.53e-7 Blood metabolite levels; CESC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg11644478 chr21:40555479 PSMG1 1.03 16.69 0.72 3.03e-43 Cognitive function; CESC cis rs17021463 0.902 rs62320439 chr4:95248721 G/C cg11021082 chr4:95130006 SMARCAD1 0.52 7.84 0.43 1.1e-13 Testicular germ cell tumor; CESC cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg17143192 chr8:8559678 CLDN23 0.77 8.87 0.48 1.09e-16 Obesity-related traits; CESC cis rs933688 0.532 rs2367292 chr5:90556785 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.45 -5.09 -0.3 6.76e-7 Smoking behavior; CESC cis rs1712517 0.545 rs3740381 chr10:105046689 G/C cg04362960 chr10:104952993 NT5C2 -0.45 -5.42 -0.32 1.37e-7 Migraine; CESC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21767207 chr19:36236454 PSENEN;U2AF1L4 -0.44 -6.07 -0.35 4.51e-9 Fibrinogen levels; CESC cis rs2953174 0.938 rs2975758 chr2:241530750 G/A cg07929629 chr2:241523174 NA 0.57 5.33 0.31 2.15e-7 Bipolar disorder; CESC cis rs1707322 1.000 rs4134387 chr1:46395158 A/T cg03146154 chr1:46216737 IPP 0.78 10.77 0.55 1.17e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Depression; CESC cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.22 0.31 3.57e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19226866 chr11:63993875 NUDT22;TRPT1 -0.59 -6.3 -0.36 1.21e-9 Gut microbiome composition (summer); CESC cis rs1707322 0.835 rs946525 chr1:46487277 A/T cg03146154 chr1:46216737 IPP -0.72 -9.88 -0.52 8.55e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg02034447 chr16:89574710 SPG7 0.55 7.09 0.4 1.24e-11 Multiple myeloma (IgH translocation); CESC cis rs137699 1.000 rs5757632 chr22:39756097 A/C cg24399712 chr22:39784796 NA -0.4 -5.24 -0.31 3.22e-7 IgG glycosylation; CESC cis rs6499255 0.904 rs7190652 chr16:69616292 C/G cg15192750 chr16:69999425 NA 0.53 6.19 0.36 2.33e-9 IgE levels; CESC cis rs5758659 1.000 rs5758659 chr22:42622003 C/T cg15557168 chr22:42548783 NA -0.49 -7.77 -0.43 1.73e-13 Cognitive function; CESC cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg05340658 chr4:99064831 C4orf37 -0.83 -12.91 -0.62 6.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.830 rs2735309 chr21:40715313 C/T cg17971929 chr21:40555470 PSMG1 0.92 12.31 0.6 7.68e-28 Cognitive function; CESC cis rs10504073 0.647 rs10504072 chr8:49993083 G/A cg00325661 chr8:49890786 NA 0.55 8.17 0.45 1.29e-14 Blood metabolite ratios; CESC cis rs4604732 0.631 rs12036460 chr1:247626928 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6432018 0.927 rs6432023 chr2:9736874 C/T cg23886495 chr2:9695866 ADAM17 0.43 5.06 0.3 7.74e-7 Heart rate variability traits; CESC cis rs501120 0.810 rs541483 chr10:44746395 A/G cg09554077 chr10:44749378 NA 0.5 6.29 0.36 1.34e-9 Coronary artery disease;Coronary heart disease; CESC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg12311346 chr5:56204834 C5orf35 0.42 5.06 0.3 7.84e-7 Coronary artery disease; CESC cis rs5753618 0.504 rs9606848 chr22:31901867 G/A cg00478049 chr22:31556069 RNF185 -0.46 -5.53 -0.32 7.55e-8 Colorectal cancer; CESC cis rs3749237 0.557 rs7631908 chr3:49425707 T/G cg06212747 chr3:49208901 KLHDC8B 0.53 7.2 0.4 6.14e-12 Resting heart rate; CESC cis rs1348850 0.519 rs13034781 chr2:178523550 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.04 0.4 1.67e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27248073 chr17:6347727 FAM64A 0.55 6.62 0.38 2e-10 Gut microbiome composition (summer); CESC cis rs7659604 0.502 rs13106764 chr4:122699630 C/G cg19671926 chr4:122722719 EXOSC9 0.65 8.58 0.47 7.87e-16 Type 2 diabetes; CESC cis rs6939532 0.522 rs6933583 chr6:26355283 A/C cg14345882 chr6:26364793 BTN3A2 0.4 6.24 0.36 1.7e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2486288 0.656 rs8039352 chr15:45551790 A/G cg09092052 chr15:45571596 NA 0.45 5.37 0.31 1.72e-7 Glomerular filtration rate; CESC cis rs963731 0.649 rs10166801 chr2:39250771 C/T cg04010122 chr2:39346883 SOS1 -0.77 -5.69 -0.33 3.29e-8 Corticobasal degeneration; CESC cis rs7809950 0.834 rs3801946 chr7:107242995 T/A cg23024343 chr7:107201750 COG5 0.46 6.24 0.36 1.76e-9 Coronary artery disease; CESC cis rs4969178 0.645 rs4490057 chr17:76375095 C/T cg05887092 chr17:76393375 PGS1 -0.6 -9.38 -0.5 3.08e-18 HDL cholesterol levels; CESC cis rs12291225 0.585 rs12270374 chr11:14375079 T/C cg19336497 chr11:14380999 RRAS2 -0.45 -6.59 -0.38 2.32e-10 Sense of smell; CESC cis rs3008870 1.000 rs7511948 chr1:67430427 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs6547741 0.935 rs4666005 chr2:27855239 A/G cg21248554 chr2:27665150 KRTCAP3 0.27 5.7 0.33 3.16e-8 Oral cavity cancer; CESC trans rs6089829 0.925 rs6062396 chr20:61667949 T/C cg23505145 chr19:12996616 KLF1 0.51 6.68 0.38 1.37e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs324780 0.544 rs401687 chr12:83924986 G/C cg22140261 chr22:42466895 NAGA -0.48 -6.12 -0.35 3.34e-9 Vertical cup-disc ratio; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27294288 chr5:170750725 NA 0.45 6.16 0.35 2.65e-9 Fibrinogen levels; CESC cis rs17376456 1.000 rs9968749 chr5:93509559 A/G cg25358565 chr5:93447407 FAM172A 1.14 11.21 0.57 4.02e-24 Diabetic retinopathy; CESC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg27170947 chr2:26402098 FAM59B -0.57 -6.76 -0.38 8.73e-11 Gut microbiome composition (summer); CESC cis rs894734 0.535 rs7301643 chr12:54325796 G/T cg17410650 chr12:54324560 NA -0.46 -8.26 -0.45 6.82e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CESC cis rs4891159 0.790 rs72975929 chr18:74144630 G/C cg24786174 chr18:74118243 ZNF516 -0.73 -11.05 -0.56 1.39e-23 Longevity; CESC cis rs2249625 0.844 rs2463749 chr6:72918148 C/G cg18830697 chr6:72922368 RIMS1 0.38 5.35 0.31 1.92e-7 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs2733201 1.000 rs11635948 chr15:44286094 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.59 -5.37 -0.31 1.7e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg05347473 chr6:146136440 FBXO30 0.55 7.01 0.4 2.02e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg06481639 chr22:41940642 POLR3H -0.66 -6.62 -0.38 2e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs6964587 0.967 rs6974827 chr7:91772945 C/T cg17063962 chr7:91808500 NA 0.59 8.22 0.45 8.94e-15 Breast cancer; CESC cis rs30380 1.000 rs151964 chr5:96123666 G/T cg16492584 chr5:96139282 ERAP1 -0.35 -5.35 -0.31 1.95e-7 Cerebrospinal fluid biomarker levels; CESC cis rs34779708 0.931 rs11596502 chr10:35387187 A/C cg03585969 chr10:35415529 CREM 0.75 9.77 0.51 1.82e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg00080972 chr5:178986291 RUFY1 0.44 6.98 0.39 2.35e-11 Lung cancer; CESC cis rs9486719 0.857 rs4839833 chr6:96882069 T/C cg06623918 chr6:96969491 KIAA0776 0.89 10.34 0.54 2.9e-21 Migraine;Coronary artery disease; CESC cis rs473651 1.000 rs473651 chr2:239335401 A/C cg21699342 chr2:239360505 ASB1 0.53 8.62 0.47 6.06e-16 Multiple system atrophy; CESC cis rs4843747 0.519 rs12599755 chr16:88107006 A/G cg06374794 chr16:88002281 BANP 0.4 5.13 0.3 5.56e-7 Menopause (age at onset); CESC cis rs7223966 1.000 rs11079509 chr17:61762148 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 5.05 0.3 8.31e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7589342 0.899 rs11885225 chr2:106486548 T/C cg14210321 chr2:106509881 NCK2 -0.47 -5.35 -0.31 1.88e-7 Addiction; CESC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg06074448 chr4:187884817 NA -0.37 -5.43 -0.32 1.27e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs10493773 0.609 rs3753789 chr1:86174814 T/C cg17807903 chr1:86174739 ZNHIT6 -0.44 -6.5 -0.37 3.91e-10 Urate levels in overweight individuals; CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg17178900 chr1:205818956 PM20D1 0.85 14.81 0.67 1.47e-36 Menarche (age at onset); CESC cis rs9549367 0.789 rs9549695 chr13:113874814 A/G cg18105134 chr13:113819100 PROZ 0.59 7.24 0.41 4.73e-12 Platelet distribution width; CESC cis rs30380 1.000 rs30380 chr5:96122281 A/C cg16492584 chr5:96139282 ERAP1 -0.35 -5.35 -0.31 1.89e-7 Cerebrospinal fluid biomarker levels; CESC cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg14829155 chr15:31115871 NA -0.71 -9.41 -0.5 2.57e-18 Huntington's disease progression; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg23672752 chr16:66785618 DYNC1LI2 -0.42 -6.0 -0.35 6.59e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9611565 0.512 rs139573 chr22:42214785 G/A cg03806693 chr22:41940476 POLR3H -1.14 -13.25 -0.63 4.18e-31 Vitiligo; CESC cis rs7617480 0.648 rs6766238 chr3:48801929 G/A cg06212747 chr3:49208901 KLHDC8B 0.46 5.39 0.31 1.59e-7 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs9660992 0.649 rs12128254 chr1:205268097 C/T cg21643547 chr1:205240462 TMCC2 -0.47 -6.19 -0.36 2.23e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg22907277 chr7:1156413 C7orf50 0.46 5.4 0.32 1.45e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg23172400 chr8:95962367 TP53INP1 -0.44 -9.18 -0.49 1.3e-17 Type 2 diabetes; CESC trans rs4471313 0.956 rs3119904 chr1:170352054 T/G cg14876685 chr7:99177937 NA -0.4 -6.15 -0.35 2.85e-9 Waist-hip ratio; CESC cis rs13095912 0.785 rs34619288 chr3:185331678 G/C cg11274856 chr3:185301563 NA 0.36 5.19 0.3 4.28e-7 Systolic blood pressure; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg16145915 chr7:1198662 ZFAND2A -0.82 -15.27 -0.68 3.45e-38 Longevity;Endometriosis; CESC cis rs3733585 0.699 rs7683283 chr4:9969974 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.6 -0.33 5.49e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg25036284 chr2:26402008 FAM59B -0.86 -9.4 -0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs1691799 0.899 rs1168321 chr12:66744517 C/G cg16791601 chr12:66731901 HELB 0.79 14.58 0.67 9.12e-36 White blood cell count (basophil); CESC cis rs10089 0.953 rs17164427 chr5:127361736 C/G cg19767477 chr5:127420684 SLC12A2 0.4 5.43 0.32 1.26e-7 Ileal carcinoids; CESC cis rs11785693 0.862 rs11782556 chr8:5002389 C/G cg26367366 chr8:4980734 NA 0.79 7.5 0.42 9.6e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg19717773 chr7:2847554 GNA12 -0.47 -6.75 -0.38 9.38e-11 Height; CESC cis rs1707322 1.000 rs10890372 chr1:46391020 T/G cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7586879 0.575 rs6744205 chr2:25133148 T/C cg01884057 chr2:25150051 NA 0.36 7.03 0.4 1.8e-11 Body mass index; CESC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.56 0.42 6.72e-13 Prudent dietary pattern; CESC cis rs2985684 1.000 rs11157696 chr14:50105746 C/G cg02151108 chr14:50098012 C14orf104 0.4 5.21 0.3 3.85e-7 Carotid intima media thickness; CESC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.11 -0.3 6.3e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1348850 0.958 rs11684320 chr2:178456346 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.32 0.46 4.74e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2011503 1.000 rs7252453 chr19:19654117 G/C cg03709012 chr19:19516395 GATAD2A 0.53 5.47 0.32 1.03e-7 Bipolar disorder; CESC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg13047869 chr3:10149882 C3orf24 0.4 5.03 0.3 8.89e-7 Alzheimer's disease; CESC cis rs1044573 0.514 rs2268879 chr20:25177805 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.37 -5.32 -0.31 2.18e-7 Allergic rhinitis; CESC trans rs2018683 0.707 rs2391718 chr7:28974988 T/C cg19402173 chr7:128379420 CALU -0.49 -6.5 -0.37 3.95e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg00802000 chr16:706648 WDR90 -0.39 -5.94 -0.34 9.01e-9 Height; CESC cis rs8017423 0.647 rs1958345 chr14:90823770 T/C cg14092571 chr14:90743983 NA 0.44 6.77 0.38 8.12e-11 Mortality in heart failure; CESC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg18876405 chr7:65276391 NA -0.45 -6.21 -0.36 2e-9 Aortic root size; CESC cis rs6582630 0.519 rs10880194 chr12:38302836 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg17372223 chr3:52568218 NT5DC2 0.46 6.92 0.39 3.4e-11 Bipolar disorder; CESC cis rs2806561 0.765 rs1738470 chr1:23511911 G/A cg12483005 chr1:23474871 LUZP1 0.39 6.15 0.35 2.78e-9 Height; CESC cis rs7914558 1.000 rs10883837 chr10:104896486 G/A cg04362960 chr10:104952993 NT5C2 0.46 5.92 0.34 9.98e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03260790 chr12:56211718 ORMDL2;SARNP -0.57 -6.26 -0.36 1.56e-9 Gut microbiome composition (summer); CESC cis rs7635838 0.654 rs4684766 chr3:11285474 G/A cg00170343 chr3:11313890 ATG7 0.53 7.31 0.41 3.13e-12 HDL cholesterol; CESC cis rs2985684 0.901 rs7146248 chr14:50112067 C/T cg02151108 chr14:50098012 C14orf104 -0.4 -5.13 -0.3 5.53e-7 Carotid intima media thickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21872608 chr12:54121322 CALCOCO1 0.69 7.44 0.42 1.43e-12 Gut microbiome composition (summer); CESC cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.29 0.31 2.52e-7 Personality dimensions; CESC cis rs709400 1.000 rs861538 chr14:104166733 C/T cg12935359 chr14:103987150 CKB -0.46 -6.22 -0.36 1.91e-9 Body mass index; CESC cis rs4604732 0.536 rs12058821 chr1:247649651 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.46 5.85 0.34 1.41e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg00149659 chr3:10157352 C3orf10 0.74 8.69 0.47 3.76e-16 Alzheimer's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01812826 chr8:123793836 ZHX2 -0.43 -6.0 -0.35 6.6e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1707322 0.721 rs10890333 chr1:46100322 T/C cg05343316 chr1:45956843 TESK2 0.51 6.26 0.36 1.51e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6088580 0.634 rs6059829 chr20:33017074 G/A cg06115741 chr20:33292138 TP53INP2 0.48 6.14 0.35 3e-9 Glomerular filtration rate (creatinine); CESC cis rs7236492 0.683 rs78250476 chr18:77198934 G/A cg15644404 chr18:77186268 NFATC1 -0.69 -5.4 -0.31 1.49e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs6752107 1.000 rs6752107 chr2:234161448 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.38 5.94 0.34 9.06e-9 Crohn's disease;Inflammatory bowel disease; CESC trans rs2727020 0.681 rs1976901 chr11:49378697 T/C cg03929089 chr4:120376271 NA -0.79 -11.92 -0.59 1.64e-26 Coronary artery disease; CESC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg18099408 chr3:52552593 STAB1 -0.32 -5.17 -0.3 4.69e-7 Bipolar disorder; CESC cis rs713587 0.525 rs11675457 chr2:25079770 C/T cg01884057 chr2:25150051 NA 0.35 6.73 0.38 1.06e-10 Body mass index in non-asthmatics; CESC cis rs17384381 0.859 rs35761966 chr1:85918357 G/A cg16011679 chr1:85725395 C1orf52 0.69 6.85 0.39 5.08e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00436174 chr2:128051630 ERCC3 -0.45 -6.14 -0.35 3.01e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs763121 0.853 rs926299 chr22:39095698 C/G cg21395723 chr22:39101663 GTPBP1 0.49 6.67 0.38 1.5e-10 Menopause (age at onset); CESC cis rs10883723 0.738 rs715438 chr10:104258303 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -5.94 -0.34 8.94e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs2760061 0.626 rs672907 chr1:228120345 G/A cg02753203 chr1:228287806 NA -0.51 -7.43 -0.42 1.5e-12 Diastolic blood pressure; CESC cis rs1348850 0.526 rs7582179 chr2:178370631 A/G cg22681709 chr2:178499509 PDE11A -0.5 -5.32 -0.31 2.2e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.1e-10 Bipolar disorder; CESC cis rs74181299 0.784 rs2723085 chr2:65297359 C/G cg05010058 chr2:65284262 CEP68 0.34 5.74 0.33 2.58e-8 Pulse pressure; CESC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.55 0.64 3.99e-32 Prudent dietary pattern; CESC cis rs1728785 0.901 rs1170420 chr16:68635877 G/C cg02972257 chr16:68554789 NA -0.63 -7.01 -0.4 1.94e-11 Ulcerative colitis; CESC trans rs3733585 0.660 rs13122290 chr4:9933832 A/G cg26043149 chr18:55253948 FECH -0.43 -6.04 -0.35 5.22e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.782 rs6518309 chr21:45047992 C/A cg01579765 chr21:45077557 HSF2BP -0.56 -8.51 -0.46 1.34e-15 Mean corpuscular volume; CESC cis rs7264396 0.635 rs6058346 chr20:34481043 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.19 -0.57 4.57e-24 Total cholesterol levels; CESC cis rs2243480 1.000 rs2420171 chr7:65637760 T/C cg13147721 chr7:65941812 NA 0.97 9.19 0.49 1.2e-17 Diabetic kidney disease; CESC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.48 -0.32 1.01e-7 Developmental language disorder (linguistic errors); CESC cis rs8067354 0.574 rs1291947 chr17:57996336 G/T cg02344993 chr17:57696989 CLTC 0.52 5.61 0.33 5.15e-8 Hemoglobin concentration; CESC cis rs11098499 0.863 rs10004484 chr4:120442428 C/T cg09307838 chr4:120376055 NA 0.91 12.35 0.6 5.59e-28 Corneal astigmatism; CESC cis rs1008375 0.966 rs3775925 chr4:17588437 A/G cg02297831 chr4:17616191 MED28 0.5 6.12 0.35 3.36e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs916888 0.821 rs199507 chr17:44858855 A/G cg17911788 chr17:44343683 NA 0.53 7.2 0.4 6.14e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs2121875 0.667 rs4637558 chr5:44224783 G/A cg09056876 chr6:156718398 NA -0.48 -6.13 -0.35 3.09e-9 Prostate cancer; CESC cis rs9660992 0.573 rs1172147 chr1:205225457 G/A cg00857998 chr1:205179979 DSTYK 0.55 6.76 0.38 8.73e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs589448 0.902 rs315113 chr12:69786543 G/T cg22834771 chr12:69754056 YEATS4 0.52 7.21 0.4 5.89e-12 Cerebrospinal fluid biomarker levels; CESC cis rs2243480 1.000 rs4718309 chr7:65627764 G/C cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.25e-32 Diabetic kidney disease; CESC cis rs12048904 1.000 rs12048904 chr1:101331536 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.52 -6.83 -0.39 5.72e-11 Multiple sclerosis; CESC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg02034447 chr16:89574710 SPG7 0.48 6.17 0.35 2.48e-9 Multiple myeloma (IgH translocation); CESC cis rs16870629 0.541 rs2334955 chr5:1062444 A/G cg18655438 chr5:1077845 SLC12A7 -0.36 -5.24 -0.31 3.36e-7 QT interval; CESC cis rs2235642 0.893 rs2143285 chr16:1593171 A/G cg03771183 chr16:1608904 IFT140 0.41 5.88 0.34 1.26e-8 Coronary artery disease; CESC cis rs3106136 0.872 rs2059606 chr4:95255278 C/T cg11021082 chr4:95130006 SMARCAD1 0.36 5.2 0.3 3.99e-7 Capecitabine sensitivity; CESC cis rs1267303 0.642 rs116078607 chr1:46999238 G/A cg25110126 chr1:46999211 NA 1.07 12.0 0.59 8.98e-27 Monobrow; CESC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.73 0.33 2.76e-8 Electroencephalogram traits; CESC cis rs17376456 1.000 rs34756085 chr5:93556294 A/G cg25358565 chr5:93447407 FAM172A 1.2 10.72 0.55 1.67e-22 Diabetic retinopathy; CESC cis rs425277 1.000 rs262667 chr1:2082722 T/C cg04315214 chr1:2043799 PRKCZ -0.38 -5.36 -0.31 1.82e-7 Height; CESC cis rs11190604 1.000 rs2495737 chr10:102338344 T/C cg07080220 chr10:102295463 HIF1AN 0.6 5.52 0.32 7.97e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs1843834 0.755 rs10197382 chr2:225574650 T/C cg22455342 chr2:225449267 CUL3 0.45 5.69 0.33 3.28e-8 IgE levels in asthmatics (D.p. specific); CESC cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg05340658 chr4:99064831 C4orf37 0.78 11.87 0.59 2.5e-26 Colonoscopy-negative controls vs population controls; CESC cis rs1950626 0.750 rs35683125 chr14:101454750 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.81 11.0 0.56 2.01e-23 Pelvic organ prolapse (moderate/severe); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01110846 chr16:29937190 KCTD13 0.49 6.5 0.37 3.89e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs35110281 0.774 rs1378080 chr21:45011315 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 7.31 0.41 3.21e-12 Mean corpuscular volume; CESC cis rs9916302 0.904 rs4511574 chr17:37532916 A/G cg00129232 chr17:37814104 STARD3 -0.48 -6.01 -0.35 5.96e-9 Glomerular filtration rate (creatinine); CESC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.88e-10 Glomerular filtration rate (creatinine); CESC cis rs9768139 0.733 rs10156158 chr7:158122287 G/T cg24154853 chr7:158122151 PTPRN2 0.38 5.79 0.34 1.94e-8 Calcium levels; CESC cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg03433033 chr1:76189801 ACADM 0.75 10.58 0.54 4.7e-22 Blood metabolite levels;Acylcarnitine levels; CESC cis rs782590 0.764 rs2586969 chr2:55829392 G/C cg18811423 chr2:55921094 PNPT1 0.77 12.1 0.6 4.01e-27 Metabolic syndrome; CESC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.45 0.58 6.38e-25 Alzheimer's disease; CESC cis rs6088580 0.634 rs4911421 chr20:32998948 T/C cg06115741 chr20:33292138 TP53INP2 -0.46 -5.98 -0.34 7.28e-9 Glomerular filtration rate (creatinine); CESC cis rs72781680 1.000 rs72796337 chr2:24142957 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs7267979 0.966 rs6083817 chr20:25343998 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.07 -0.74 3.95e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg22535103 chr8:58192502 C8orf71 -1.06 -13.14 -0.63 1.04e-30 Developmental language disorder (linguistic errors); CESC trans rs459571 0.839 rs10993895 chr9:136887726 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 0.58 7.52 0.42 8.32e-13 Platelet distribution width; CESC cis rs854765 0.583 rs12452254 chr17:17829434 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.53 7.31 0.41 3.19e-12 Total body bone mineral density; CESC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.72 0.38 1.13e-10 Bipolar disorder; CESC cis rs10206020 0.921 rs11884956 chr2:1566426 A/G cg26248373 chr2:1572462 NA -0.56 -6.78 -0.38 7.98e-11 IgG glycosylation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15096432 chr1:202162128 LGR6 -0.45 -6.48 -0.37 4.49e-10 Gambling; CESC cis rs10504229 0.679 rs72649132 chr8:58054615 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -6.75 -0.38 9.05e-11 Developmental language disorder (linguistic errors); CESC cis rs6987853 0.966 rs2923428 chr8:42388301 T/C cg09913449 chr8:42400586 C8orf40 0.39 6.13 0.35 3.15e-9 Mean corpuscular hemoglobin concentration; CESC cis rs1983170 1.000 rs483532 chr1:91980447 A/G cg21854759 chr1:92012499 NA -0.48 -5.19 -0.3 4.12e-7 Eosinophil percentage of white cells; CESC cis rs13272623 0.502 rs268628 chr8:71560505 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.5 -6.33 -0.36 1.05e-9 IgG glycosylation; CESC cis rs9899728 0.539 rs11077772 chr17:73035698 C/T cg27626185 chr17:73056755 KCTD2 -1.06 -9.21 -0.49 1.05e-17 Alzheimer's disease or small vessel stroke; CESC cis rs4253772 0.530 rs9615961 chr22:46754993 T/C cg10541313 chr22:46663664 TTC38 0.75 5.27 0.31 2.83e-7 LDL cholesterol;Cholesterol, total; CESC cis rs703842 1.000 rs10783847 chr12:58196447 G/A cg18357645 chr12:58087776 OS9 -0.39 -5.51 -0.32 8.5e-8 Multiple sclerosis; CESC cis rs3015497 0.603 rs12891820 chr14:51016774 G/C cg26011998 chr14:51135199 SAV1 0.49 5.44 0.32 1.22e-7 Mean platelet volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21751787 chr5:176778504 LMAN2 0.5 6.27 0.36 1.47e-9 Gut microbiota (bacterial taxa); CESC cis rs67072384 1.000 rs11235577 chr11:72451380 C/T cg04827223 chr11:72435913 ARAP1 -0.7 -6.74 -0.38 9.93e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.22 -0.36 1.88e-9 Schizophrenia; CESC cis rs950169 0.579 rs881983 chr15:84647308 C/T cg17507749 chr15:85114479 UBE2QP1 0.62 6.02 0.35 5.73e-9 Schizophrenia; CESC cis rs10465746 0.570 rs11163884 chr1:84472760 A/G cg10977910 chr1:84465055 TTLL7 0.44 5.54 0.32 7.2e-8 Obesity-related traits; CESC cis rs6665290 0.904 rs1045290 chr1:227178700 A/G cg10327440 chr1:227177885 CDC42BPA -1.23 -34.55 -0.9 3.8e-100 Myeloid white cell count; CESC cis rs4268898 1.000 rs2303294 chr2:24432620 A/G cg06627628 chr2:24431161 ITSN2 0.63 7.39 0.41 1.89e-12 Asthma; CESC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg18446336 chr7:2847575 GNA12 -0.38 -5.58 -0.32 5.92e-8 Height; CESC cis rs258892 0.895 rs2338790 chr5:72055184 A/T cg21869765 chr5:72125136 TNPO1 -0.42 -5.32 -0.31 2.2e-7 Small cell lung carcinoma; CESC cis rs2070488 0.804 rs6764551 chr3:38460305 A/G cg24069376 chr3:38537580 EXOG 0.33 5.6 0.33 5.27e-8 Electrocardiographic conduction measures; CESC cis rs6088580 0.634 rs6059835 chr20:33020141 A/G cg08999081 chr20:33150536 PIGU 0.65 11.36 0.57 1.22e-24 Glomerular filtration rate (creatinine); CESC cis rs7772486 0.686 rs2179323 chr6:145982786 T/G cg05347473 chr6:146136440 FBXO30 -0.53 -7.03 -0.4 1.8e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs68092024 0.731 rs793480 chr3:99488364 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.43 -6.78 -0.38 7.81e-11 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22272508 chr17:34961264 MRM1 -0.66 -7.78 -0.43 1.6e-13 Gut microbiome composition (summer); CESC cis rs2191566 0.555 rs60744406 chr19:44492164 A/G cg20607764 chr19:44506953 ZNF230 -0.44 -5.51 -0.32 8.47e-8 Acute lymphoblastic leukemia (childhood); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11015833 chr12:83079681 TMTC2 0.45 6.35 0.36 9.15e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs9369898 0.963 rs9381787 chr6:49413244 G/C cg15934674 chr1:150266645 MRPS21 -0.37 -6.03 -0.35 5.37e-9 Homocysteine levels; CESC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg02931644 chr1:25747376 RHCE 0.39 6.56 0.37 2.88e-10 Erythrocyte sedimentation rate; CESC cis rs9868809 0.772 rs9877501 chr3:48718390 C/G cg07636037 chr3:49044803 WDR6 -0.61 -5.36 -0.31 1.8e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg00745463 chr17:30367425 LRRC37B -0.79 -7.2 -0.4 6.19e-12 Hip circumference adjusted for BMI; CESC cis rs9329289 0.926 rs9329290 chr10:2542751 G/T cg18171855 chr10:2543474 NA 0.36 5.61 0.33 4.99e-8 Age-related hearing impairment; CESC cis rs7607369 0.536 rs12623007 chr2:219665335 T/C cg02176678 chr2:219576539 TTLL4 -0.36 -6.37 -0.36 8.16e-10 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs6977955 1.000 rs11495981 chr7:28177301 A/G cg23620719 chr7:28220237 JAZF1 -0.48 -5.41 -0.32 1.39e-7 Allergic disease (asthma, hay fever or eczema); CESC trans rs11098499 0.954 rs11734241 chr4:120416872 A/G cg25214090 chr10:38739885 LOC399744 0.72 10.09 0.53 1.85e-20 Corneal astigmatism; CESC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16248618 chr11:65819774 SF3B2 -0.47 -6.19 -0.36 2.34e-9 Fibrinogen levels; CESC cis rs3733585 0.725 rs6449201 chr4:9973894 C/T cg02734326 chr4:10020555 SLC2A9 -0.4 -5.69 -0.33 3.43e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6424115 0.729 rs586173 chr1:24055718 A/G cg15997130 chr1:24165203 NA -0.41 -5.48 -0.32 9.71e-8 Immature fraction of reticulocytes; CESC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg02569458 chr12:86230093 RASSF9 0.53 7.64 0.42 4.03e-13 Major depressive disorder; CESC cis rs7255436 0.965 rs7249624 chr19:8446135 G/A cg16745616 chr19:8428856 ANGPTL4 -0.37 -5.67 -0.33 3.75e-8 HDL cholesterol; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.41 7.89 0.44 8.18e-14 Electroencephalogram traits; CESC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg00129232 chr17:37814104 STARD3 -0.57 -7.57 -0.42 6.31e-13 Glomerular filtration rate (creatinine); CESC trans rs6759922 1.000 rs4416248 chr2:22455521 C/T cg21162304 chr4:80247171 NAA11 0.4 6.52 0.37 3.48e-10 Subjective well-being (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08084737 chr7:43965691 URGCP;UBE2D4 -0.48 -6.88 -0.39 4.4e-11 Gut microbiota (bacterial taxa); CESC cis rs858239 0.601 rs1981665 chr7:23167969 T/C cg23682824 chr7:23144976 KLHL7 0.55 7.73 0.43 2.27e-13 Cerebrospinal fluid biomarker levels; CESC cis rs6088590 0.582 rs6059909 chr20:33139691 C/A cg08999081 chr20:33150536 PIGU 0.68 11.84 0.59 3.15e-26 Coronary artery disease; CESC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg00745463 chr17:30367425 LRRC37B -0.49 -5.41 -0.32 1.38e-7 Hip circumference adjusted for BMI; CESC cis rs1847202 0.762 rs62249896 chr3:72949857 C/G cg25664220 chr3:72788482 NA -0.38 -5.55 -0.32 7.03e-8 Motion sickness; CESC cis rs17362650 0.694 rs62118851 chr2:9566878 C/T cg12832956 chr2:9616023 IAH1 -0.59 -6.63 -0.38 1.89e-10 Alcohol dependence (age at onset); CESC cis rs7605827 0.930 rs10179765 chr2:15541249 C/T cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs6835098 0.692 rs7657374 chr4:174065756 A/T cg08422745 chr4:174089978 GALNT7 -0.62 -8.25 -0.45 7.29e-15 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg02353165 chr6:42928485 GNMT 0.88 15.25 0.68 4e-38 Alzheimer's disease in APOE e4+ carriers; CESC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.6 0.64 2.58e-32 Prudent dietary pattern; CESC trans rs637571 0.522 rs649000 chr11:65742933 T/C cg17712092 chr4:129076599 LARP1B 0.77 10.89 0.56 4.7e-23 Eosinophil percentage of white cells; CESC cis rs6120849 0.663 rs11698868 chr20:33549946 C/T cg24642439 chr20:33292090 TP53INP2 0.69 6.9 0.39 3.78e-11 Protein C levels; CESC cis rs6032067 0.561 rs6032104 chr20:43932412 G/A cg10761708 chr20:43804764 PI3 0.44 5.48 0.32 9.84e-8 Blood protein levels; CESC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg13798912 chr7:905769 UNC84A 0.54 5.31 0.31 2.31e-7 Cerebrospinal P-tau181p levels; CESC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg07677032 chr17:61819896 STRADA 0.45 5.94 0.34 8.78e-9 Prudent dietary pattern; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02983885 chr19:42772892 NA 0.5 6.44 0.37 5.65e-10 Gut microbiota (bacterial taxa); CESC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg08968635 chr6:28129556 ZNF389 0.4 5.25 0.31 3.15e-7 Depression; CESC cis rs7561273 0.586 rs11896092 chr2:24317827 G/A cg06627628 chr2:24431161 ITSN2 -0.48 -5.71 -0.33 3.03e-8 Quantitative traits; CESC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.12 0.3 5.78e-7 Menopause (age at onset); CESC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg06873352 chr17:61820015 STRADA 0.71 12.09 0.6 4.24e-27 Prudent dietary pattern; CESC cis rs7553864 0.614 rs10493796 chr1:87614175 A/G cg17420885 chr1:87600446 LOC339524 0.45 6.21 0.36 2.01e-9 Smoking behavior; CESC cis rs6120849 0.901 rs6088737 chr20:33745938 A/G cg24642439 chr20:33292090 TP53INP2 0.6 6.4 0.37 7.09e-10 Protein C levels; CESC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg11941060 chr3:133502564 NA -0.5 -6.96 -0.39 2.7e-11 Iron status biomarkers; CESC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.853 rs5757196 chr22:39039855 G/C cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg02734326 chr4:10020555 SLC2A9 0.45 6.34 0.36 9.85e-10 Bone mineral density; CESC cis rs7084402 0.875 rs1593671 chr10:60295969 A/T cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.35e-18 Refractive error; CESC cis rs6831352 0.734 rs2851259 chr4:100033986 C/T cg13256891 chr4:100009986 ADH5 0.69 8.13 0.45 1.61e-14 Alcohol dependence; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg02100365 chr1:92762956 GLMN 0.44 7.07 0.4 1.4e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2997447 0.802 rs61776621 chr1:26459058 C/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.16 0.3 4.76e-7 QRS complex (12-leadsum); CESC cis rs76525880 0.568 rs9905793 chr17:46635649 A/G cg06593406 chr17:46696139 NA -0.65 -5.57 -0.32 6.19e-8 Colorectal or endometrial cancer; CESC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.05 0.4 1.58e-11 Height; CESC cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg07701084 chr6:150067640 NUP43 0.4 5.48 0.32 9.87e-8 Lung cancer; CESC cis rs3026101 0.671 rs8067917 chr17:5278307 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.64 0.33 4.35e-8 Body mass index; CESC cis rs6582630 0.502 rs11181230 chr12:38300085 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs4727027 0.933 rs10277119 chr7:148849942 T/C cg23583168 chr7:148888333 NA -0.77 -11.36 -0.57 1.24e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs17253792 0.822 rs75763956 chr14:56071176 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs2249694 0.959 rs2987799 chr10:135380499 T/G cg20169779 chr10:135381914 SYCE1 0.39 5.47 0.32 1.06e-7 Obesity-related traits; CESC cis rs4919694 1.000 rs10509758 chr10:104681710 T/C cg04362960 chr10:104952993 NT5C2 0.74 6.45 0.37 5.42e-10 Arsenic metabolism; CESC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs12042052 1.000 rs6686747 chr1:232912743 T/C cg00951395 chr1:232941775 KIAA1383 0.7 6.94 0.39 3.02e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs2637266 0.846 rs2637263 chr10:78322442 G/A cg18941641 chr10:78392320 NA 0.38 6.9 0.39 3.72e-11 Pulmonary function; CESC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg01341218 chr17:43662625 NA -0.86 -10.6 -0.55 3.99e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9399135 0.967 rs9376075 chr6:135296963 A/G cg22676075 chr6:135203613 NA 0.52 7.21 0.4 5.94e-12 Red blood cell count; CESC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 7.0 0.4 2.07e-11 Personality dimensions; CESC cis rs3815700 1.000 rs2287670 chr19:33095057 G/A cg24916020 chr19:33096688 ANKRD27 0.59 5.75 0.33 2.5e-8 Eosinophilic esophagitis; CESC cis rs2228479 1.000 rs12596492 chr16:89957169 T/G cg06558623 chr16:89946397 TCF25 1.17 9.37 0.5 3.29e-18 Skin colour saturation; CESC cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg22875332 chr1:76189707 ACADM 0.59 6.89 0.39 4.15e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9512730 0.527 rs11619784 chr13:27999643 A/G cg04070771 chr13:27998621 GTF3A 0.54 5.79 0.34 1.98e-8 Schizophrenia; CESC cis rs1878931 0.582 rs10048083 chr16:3417465 A/C cg02880119 chr16:3481970 NA -0.39 -5.11 -0.3 6.21e-7 Body mass index (adult); CESC cis rs1577917 1.000 rs7771342 chr6:86631936 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.33 2.14e-8 Response to antipsychotic treatment; CESC cis rs4481887 0.741 rs7417519 chr1:248550370 C/T cg26353448 chr1:248524236 OR2T4 0.37 5.2 0.3 4e-7 Common traits (Other); CESC cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg18016565 chr1:150552671 MCL1 -0.42 -6.87 -0.39 4.59e-11 Tonsillectomy; CESC cis rs10751667 0.666 rs10794354 chr11:954615 A/T cg06064525 chr11:970664 AP2A2 -0.48 -9.52 -0.5 1.15e-18 Alzheimer's disease (late onset); CESC cis rs933688 1.000 rs60513756 chr5:90727692 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.97 11.16 0.57 5.75e-24 Smoking behavior; CESC cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg19077165 chr18:44547161 KATNAL2 -0.61 -9.1 -0.49 2.28e-17 Personality dimensions; CESC trans rs208520 0.661 rs207090 chr6:66783963 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.83 -0.62 1.2e-29 Exhaled nitric oxide output; CESC cis rs116095464 0.558 rs6962 chr5:256509 G/A cg22496380 chr5:211416 CCDC127 -0.79 -8.37 -0.46 3.28e-15 Breast cancer; CESC cis rs13031619 0.605 rs4849972 chr2:3698846 C/A cg19052272 chr2:3704530 ALLC 0.69 7.67 0.43 3.32e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05732646 chr13:41706942 KBTBD6 -0.39 -6.38 -0.36 7.94e-10 Gambling; CESC cis rs763014 0.898 rs2017567 chr16:637212 T/C cg00802000 chr16:706648 WDR90 -0.41 -6.33 -0.36 1.05e-9 Height; CESC cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg14403583 chr14:105418241 AHNAK2 -0.58 -8.06 -0.44 2.55e-14 Rheumatoid arthritis; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg09339876 chr11:64564812 MAP4K2 0.45 6.63 0.38 1.87e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1364705 1.000 rs12677951 chr8:120226900 C/G cg09273054 chr8:120220131 MAL2 0.61 6.75 0.38 9.08e-11 Hippocampal atrophy; CESC cis rs3749237 0.595 rs4955412 chr3:49418168 A/C cg03060546 chr3:49711283 APEH 0.75 11.31 0.57 1.91e-24 Resting heart rate; CESC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg20744362 chr22:50050164 C22orf34 0.46 8.0 0.44 3.89e-14 Monocyte count;Monocyte percentage of white cells; CESC cis rs4423214 0.959 rs11233747 chr11:71171642 G/A cg05163923 chr11:71159392 DHCR7 0.78 10.34 0.54 2.91e-21 Vitamin D levels; CESC cis rs9325144 1.000 rs9325144 chr12:39018673 C/T cg26384229 chr12:38710491 ALG10B -0.47 -5.8 -0.34 1.87e-8 Morning vs. evening chronotype; CESC cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg06212747 chr3:49208901 KLHDC8B 0.69 9.04 0.49 3.3e-17 Parkinson's disease; CESC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.15 -0.35 2.82e-9 Total body bone mineral density; CESC cis rs898097 0.841 rs8074284 chr17:80909967 G/A cg10494973 chr17:80897199 TBCD -0.5 -5.77 -0.33 2.26e-8 Breast cancer; CESC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.77 8.42 0.46 2.43e-15 Mean platelet volume; CESC cis rs8040855 0.627 rs11634975 chr15:85606478 T/C cg08123816 chr15:85640762 PDE8A -0.38 -5.74 -0.33 2.54e-8 Bulimia nervosa; CESC cis rs3859192 0.561 rs34453912 chr17:38180352 T/A cg17467752 chr17:38218738 THRA -0.45 -5.9 -0.34 1.13e-8 White blood cell count; CESC cis rs12477438 0.520 rs7572660 chr2:99788582 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.34 0.69 1.93e-38 Chronic sinus infection; CESC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs66573146 0.572 rs66734745 chr4:6948765 T/C cg07817883 chr1:32538562 TMEM39B 1.19 8.24 0.45 7.79e-15 Granulocyte percentage of myeloid white cells; CESC cis rs2455799 0.573 rs2455829 chr3:15746937 G/A cg09340198 chr3:15902540 ANKRD28 -0.33 -5.14 -0.3 5.37e-7 Mean platelet volume; CESC cis rs962856 0.619 rs11890682 chr2:67589585 A/G cg09028215 chr2:67624308 ETAA1 -0.44 -5.3 -0.31 2.43e-7 Pancreatic cancer; CESC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg23758822 chr17:41437982 NA 1.0 14.95 0.68 4.7e-37 Menopause (age at onset); CESC cis rs7828089 0.582 rs13282084 chr8:22266280 T/C cg13512537 chr8:22265999 SLC39A14 -0.36 -5.1 -0.3 6.53e-7 Verbal declarative memory; CESC trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg15704280 chr7:45808275 SEPT13 -1.04 -20.38 -0.78 3.56e-56 Height; CESC cis rs7246657 0.943 rs4803460 chr19:37885228 T/C cg23950597 chr19:37808831 NA -0.54 -5.9 -0.34 1.11e-8 Coronary artery calcification; CESC cis rs4132509 0.744 rs10803146 chr1:243709454 T/G cg21452805 chr1:244014465 NA 0.59 6.33 0.36 1.05e-9 RR interval (heart rate); CESC cis rs748404 0.697 rs579651 chr15:43558376 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.77 0.43 1.69e-13 Lung cancer; CESC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg24562669 chr7:97807699 LMTK2 0.51 7.54 0.42 7.27e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs11764590 0.694 rs4721359 chr7:2104951 A/G cg21782813 chr7:2030301 MAD1L1 -0.42 -5.41 -0.32 1.42e-7 Neuroticism; CESC cis rs599083 0.530 rs667126 chr11:68177728 C/T cg16797656 chr11:68205561 LRP5 -0.4 -5.38 -0.31 1.6e-7 Bone mineral density (spine); CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg05564831 chr3:52568323 NT5DC2 0.48 8.08 0.44 2.36e-14 Cognitive function; CESC cis rs13095912 1.000 rs7374856 chr3:185311964 A/C cg11274856 chr3:185301563 NA 0.36 5.87 0.34 1.3e-8 Systolic blood pressure; CESC cis rs8017423 0.740 rs7152196 chr14:90703900 G/T cg14092571 chr14:90743983 NA -0.56 -8.3 -0.45 5.2e-15 Mortality in heart failure; CESC cis rs12142240 0.698 rs6695043 chr1:46844530 A/G cg00530320 chr1:46809349 NSUN4 -0.58 -7.98 -0.44 4.42e-14 Menopause (age at onset); CESC cis rs7089973 0.624 rs1359080 chr10:116582419 C/A cg23260525 chr10:116636907 FAM160B1 0.38 6.81 0.39 6.44e-11 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9549367 0.713 rs9549357 chr13:113860121 C/T cg00898013 chr13:113819073 PROZ -0.49 -7.07 -0.4 1.41e-11 Platelet distribution width; CESC cis rs7000551 0.715 rs7839577 chr8:22307325 T/A cg12081754 chr8:22256438 SLC39A14 0.44 5.91 0.34 1.08e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs60843830 1.000 rs114976176 chr2:264621 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.88 11.92 0.59 1.67e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7651736 1.000 rs7651736 chr3:136760598 A/G cg03617693 chr3:136751559 NA 0.39 6.37 0.36 8.11e-10 Neuroticism; CESC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg22974920 chr21:40686053 BRWD1 -0.46 -5.73 -0.33 2.77e-8 Cognitive function; CESC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg02592271 chr2:27665507 KRTCAP3 0.29 5.66 0.33 3.85e-8 Total body bone mineral density; CESC cis rs2197308 0.692 rs67352173 chr12:37906912 A/T cg26384229 chr12:38710491 ALG10B 0.67 9.69 0.51 3.43e-19 Morning vs. evening chronotype; CESC cis rs897984 0.806 rs9319588 chr16:30930983 C/T cg00531865 chr16:30841666 NA 0.51 7.12 0.4 1.01e-11 Dementia with Lewy bodies; CESC cis rs3768617 0.706 rs11588675 chr1:182988052 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 9.8 0.52 1.51e-19 Fuchs's corneal dystrophy; CESC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.61 0.42 4.95e-13 Prudent dietary pattern; CESC cis rs9911578 0.935 rs6503878 chr17:56884581 T/G cg05425664 chr17:57184151 TRIM37 -0.49 -6.87 -0.39 4.62e-11 Intelligence (multi-trait analysis); CESC cis rs4474742 1 rs4474742 chr17:28065578 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.22 -0.53 6.81e-21 Monocyte count; CESC cis rs7949030 0.596 rs11231137 chr11:62315699 G/A cg13298116 chr11:62369859 EML3;MTA2 0.51 7.03 0.4 1.72e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6740322 0.748 rs6544635 chr2:43486704 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.77 -8.25 -0.45 7.31e-15 Coronary artery disease; CESC cis rs2932538 0.885 rs7516421 chr1:113089696 T/C cg22162597 chr1:113214053 CAPZA1 0.46 6.1 0.35 3.73e-9 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg16145915 chr7:1198662 ZFAND2A -0.49 -5.47 -0.32 1.02e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg20891558 chr2:74357851 NA 0.82 12.12 0.6 3.38e-27 Gestational age at birth (maternal effect); CESC cis rs7264396 0.790 rs2425097 chr20:34308926 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.32 0.41 2.93e-12 Total cholesterol levels; CESC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg07677032 chr17:61819896 STRADA 0.41 5.33 0.31 2.15e-7 Prudent dietary pattern; CESC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg11764359 chr7:65958608 NA -0.79 -11.64 -0.58 1.44e-25 Aortic root size; CESC cis rs75477785 0.590 rs10863809 chr1:210253684 G/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.95 6.41 0.37 6.82e-10 Cleft lip with or without cleft palate; CESC cis rs1577917 1.000 rs12204365 chr6:86700532 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.82 -0.34 1.67e-8 Response to antipsychotic treatment; CESC cis rs3820068 0.603 rs16851884 chr1:15961871 A/G cg13390004 chr1:15929781 NA 0.37 5.9 0.34 1.11e-8 Systolic blood pressure; CESC cis rs2635047 0.566 rs8092050 chr18:44796323 C/T cg24371990 chr18:44770781 NA 0.39 6.27 0.36 1.48e-9 Educational attainment; CESC cis rs7264396 0.563 rs2425122 chr20:34328848 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.88e-22 Total cholesterol levels; CESC cis rs1153858 1.000 rs61365925 chr15:45650311 T/C cg21132104 chr15:45694354 SPATA5L1 0.84 11.41 0.57 8.8e-25 Homoarginine levels; CESC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg19163074 chr7:65112434 INTS4L2 0.46 5.05 0.3 8.07e-7 Aortic root size; CESC cis rs17376456 0.825 rs67328989 chr5:93243133 T/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.65 5.24 0.31 3.28e-7 Diabetic retinopathy; CESC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg14926445 chr8:58193284 C8orf71 -0.49 -5.28 -0.31 2.73e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15277511 chr18:43678182 ATP5A1 0.62 6.81 0.39 6.39e-11 Gut microbiome composition (summer); CESC cis rs2742234 0.590 rs2505553 chr10:43681251 G/T cg07801480 chr10:43725741 RASGEF1A 0.41 5.28 0.31 2.72e-7 Hirschsprung disease; CESC cis rs2239547 0.563 rs9839035 chr3:52909877 C/T cg11645453 chr3:52864694 ITIH4 0.35 5.97 0.34 7.68e-9 Schizophrenia; CESC cis rs11264213 0.786 rs79674501 chr1:36270589 G/A cg27506609 chr1:36549197 TEKT2 0.61 5.04 0.3 8.54e-7 Schizophrenia; CESC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg20744362 chr22:50050164 C22orf34 0.47 8.17 0.45 1.26e-14 Monocyte count;Monocyte percentage of white cells; CESC cis rs6087990 0.735 rs2889703 chr20:31379184 C/A cg13636640 chr20:31349939 DNMT3B 0.75 11.68 0.58 1.04e-25 Ulcerative colitis; CESC cis rs920590 0.876 rs3907477 chr8:19657744 C/T cg17834443 chr8:19674713 INTS10 0.49 5.78 0.33 2.13e-8 Acute lymphoblastic leukemia (childhood); CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00275962 chr6:43484808 POLR1C;YIPF3 0.48 6.57 0.37 2.69e-10 Intelligence (multi-trait analysis); CESC cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 6.1e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs9291683 0.609 rs55959894 chr4:10026580 G/A cg02734326 chr4:10020555 SLC2A9 0.47 6.52 0.37 3.47e-10 Bone mineral density; CESC cis rs412000 0.560 rs4793583 chr17:56451407 A/C cg05425664 chr17:57184151 TRIM37 0.4 5.5 0.32 8.94e-8 Primary tooth development (time to first tooth eruption); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16092991 chr4:15004611 CPEB2 0.48 6.2 0.36 2.2e-9 Gut microbiota (bacterial taxa); CESC cis rs8062405 0.929 rs11864750 chr16:28875204 A/T cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg15485101 chr11:133734466 NA 0.41 6.66 0.38 1.57e-10 Childhood ear infection; CESC cis rs12887734 0.524 rs4906364 chr14:104214342 C/G cg08213375 chr14:104286397 PPP1R13B 0.42 7.06 0.4 1.46e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs9611565 0.571 rs2050032 chr22:42152429 C/T cg03806693 chr22:41940476 POLR3H 0.85 10.66 0.55 2.56e-22 Vitiligo; CESC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.34 0.41 2.56e-12 Tonsillectomy; CESC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.38 5.04 0.3 8.73e-7 Menopause (age at onset); CESC cis rs7917772 0.582 rs10883736 chr10:104320029 G/T ch.10.2196322F chr10:104248062 ACTR1A 0.41 5.19 0.3 4.27e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs8082590 1 rs8082590 chr17:17958402 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.6 -8.42 -0.46 2.43e-15 Schizophrenia; CESC cis rs2637266 0.967 rs4979898 chr10:78355672 G/A cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg14393609 chr7:65229607 NA 0.52 7.08 0.4 1.33e-11 Aortic root size; CESC cis rs684232 0.623 rs417171 chr17:576941 A/G cg15660573 chr17:549704 VPS53 -0.65 -8.94 -0.48 6.83e-17 Prostate cancer; CESC cis rs12079745 1.000 rs74967728 chr1:169202731 C/T cg09363564 chr1:169337483 NME7;BLZF1 -1.03 -6.33 -0.36 1.04e-9 QT interval; CESC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg11764359 chr7:65958608 NA -0.91 -13.85 -0.65 3.33e-33 Aortic root size; CESC cis rs2011503 0.882 rs4808933 chr19:19363812 T/A cg11584989 chr19:19387371 SF4 0.53 6.41 0.37 6.52e-10 Bipolar disorder; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg04769705 chr14:69262517 C14orf181 -0.49 -6.34 -0.36 9.73e-10 Thyroid stimulating hormone; CESC cis rs11690935 1.000 rs312924 chr2:172564021 A/T cg13550731 chr2:172543902 DYNC1I2 0.92 13.68 0.64 1.4e-32 Schizophrenia; CESC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg13206674 chr6:150067644 NUP43 0.4 5.43 0.32 1.25e-7 Lung cancer; CESC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.33 5.59 0.32 5.66e-8 Bipolar disorder; CESC cis rs7647973 0.587 rs10452032 chr3:49680973 G/A cg13072238 chr3:49761600 GMPPB -0.45 -5.47 -0.32 1.04e-7 Menarche (age at onset); CESC cis rs9818941 0.956 rs4317052 chr3:157721994 C/T cg08654915 chr3:157813417 NA 0.4 7.48 0.42 1.06e-12 Height; CESC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg08888203 chr3:10149979 C3orf24 0.47 6.03 0.35 5.45e-9 Alzheimer's disease; CESC cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.46 7.73 0.43 2.2e-13 Monocyte percentage of white cells; CESC cis rs12586317 0.547 rs12435454 chr14:35466997 A/G cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC cis rs12824058 0.831 rs4759451 chr12:130812739 G/A cg23887609 chr12:130822674 PIWIL1 0.44 5.7 0.33 3.2e-8 Menopause (age at onset); CESC cis rs11828289 0.607 rs78341320 chr11:23188865 C/T cg20040320 chr11:23191996 NA -0.68 -5.87 -0.34 1.31e-8 Cancer; CESC cis rs17125944 0.505 rs75661138 chr14:53259262 G/A cg00686598 chr14:53173677 PSMC6 1.42 11.79 0.59 4.37e-26 Alzheimer's disease (late onset); CESC cis rs3820068 0.637 rs4646080 chr1:15826627 A/T cg18192808 chr1:15853278 DNAJC16 0.47 5.78 0.33 2.05e-8 Systolic blood pressure; CESC cis rs9308731 0.966 rs6753785 chr2:111923630 T/G cg04202892 chr2:111875749 ACOXL 0.36 5.21 0.31 3.73e-7 Chronic lymphocytic leukemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21400344 chr1:25870172 LDLRAP1 0.57 6.26 0.36 1.55e-9 Gut microbiome composition (summer); CESC cis rs12500824 0.564 rs62300857 chr4:77284421 G/T cg20311846 chr4:77356250 SHROOM3 0.37 6.88 0.39 4.32e-11 Coronary artery disease; CESC trans rs17685 0.725 rs6467993 chr7:75719350 G/A cg19862616 chr7:65841803 NCRNA00174 0.83 11.96 0.59 1.23e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs8067545 0.611 rs4925090 chr17:20066631 C/T cg13482628 chr17:19912719 NA 0.43 5.74 0.33 2.65e-8 Schizophrenia; CESC cis rs12545109 0.876 rs1992120 chr8:57337112 G/A cg09654669 chr8:57350985 NA -0.6 -7.06 -0.4 1.48e-11 Obesity-related traits; CESC cis rs36051895 0.623 rs11506292 chr9:5257048 C/A cg02405213 chr9:5042618 JAK2 -0.54 -6.37 -0.36 8.41e-10 Pediatric autoimmune diseases; CESC cis rs9908102 0.740 rs56369392 chr17:12904928 C/T cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg00339695 chr16:24857497 SLC5A11 0.51 6.71 0.38 1.19e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7618501 0.966 rs13085679 chr3:49869631 G/A cg24308560 chr3:49941425 MST1R -0.53 -7.28 -0.41 3.78e-12 Intelligence (multi-trait analysis); CESC cis rs7656342 0.622 rs10009838 chr4:9833882 G/A cg11266682 chr4:10021025 SLC2A9 0.32 5.15 0.3 5.17e-7 Gut microbiota (bacterial taxa); CESC cis rs3733585 0.699 rs7677710 chr4:9969517 T/G cg00071950 chr4:10020882 SLC2A9 -0.69 -11.47 -0.58 5.42e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2439831 0.867 rs8041132 chr15:43635136 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.46 0.54 1.19e-21 Lung cancer in ever smokers; CESC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg01475735 chr3:40494733 NA -0.4 -5.1 -0.3 6.47e-7 Renal cell carcinoma; CESC cis rs11252926 0.537 rs4554800 chr10:458477 G/T cg18196295 chr10:418757 DIP2C -0.55 -7.62 -0.42 4.6e-13 Psychosis in Alzheimer's disease; CESC cis rs694739 0.726 rs17857342 chr11:64138905 T/G cg02228329 chr11:64053129 BAD;GPR137 0.62 7.62 0.42 4.42e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs11792861 0.926 rs7470160 chr9:111844246 C/A cg05043794 chr9:111880884 C9orf5 -0.41 -6.74 -0.38 9.83e-11 Menarche (age at onset); CESC cis rs597539 0.690 rs7129960 chr11:68622456 A/G cg04772025 chr11:68637568 NA 0.53 5.93 0.34 9.67e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8072100 0.871 rs7206971 chr17:45425115 A/G cg25173405 chr17:45401733 C17orf57 0.45 6.08 0.35 4.21e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9926296 0.656 rs2376884 chr16:89826922 C/T cg27121462 chr16:89883253 FANCA 0.54 6.79 0.39 7.27e-11 Vitiligo; CESC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs3733585 0.746 rs4318650 chr4:10016868 T/C cg02734326 chr4:10020555 SLC2A9 0.42 5.76 0.33 2.3e-8 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19451435 chr6:158402916 SYNJ2 0.68 8.12 0.45 1.8e-14 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs4807542 1.000 rs4807542 chr19:1104078 G/A cg09432775 chr19:1117453 SBNO2 0.38 5.15 0.3 5.09e-7 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg02574844 chr11:5959923 NA -0.46 -7.02 -0.4 1.9e-11 DNA methylation (variation); CESC cis rs10754283 0.967 rs6663363 chr1:90116854 A/G cg21401794 chr1:90099060 LRRC8C 0.67 8.97 0.48 5.53e-17 Amyotrophic lateral sclerosis (sporadic); CESC cis rs8002861 0.905 rs11617551 chr13:44443977 T/C cg14210620 chr13:44453864 C13orf31;CCDC122 -0.44 -5.65 -0.33 4.21e-8 Leprosy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14428669 chr9:114659192 UGCG 0.61 7.33 0.41 2.87e-12 Gut microbiome composition (summer); CESC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg03452623 chr4:187889614 NA -0.89 -14.8 -0.67 1.53e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg00166722 chr3:10149974 C3orf24 0.46 5.89 0.34 1.18e-8 Alzheimer's disease; CESC cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.95 14.08 0.65 5.33e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12479064 0.724 rs28369945 chr2:100080928 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -6.72 -0.38 1.14e-10 Chronic sinus infection; CESC cis rs992157 0.798 rs1017698 chr2:219170525 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.66 -9.07 -0.49 2.81e-17 Colorectal cancer; CESC cis rs7662987 1.000 rs28730640 chr4:99994053 C/T cg13256891 chr4:100009986 ADH5 -0.81 -6.09 -0.35 4.04e-9 Smoking initiation; CESC cis rs1003719 0.715 rs2835613 chr21:38496883 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.64 -8.74 -0.47 2.66e-16 Eye color traits; CESC cis rs3126085 0.935 rs1496050 chr1:152163549 T/C cg03465714 chr1:152285911 FLG -0.44 -5.33 -0.31 2.06e-7 Atopic dermatitis; CESC cis rs7149242 0.796 rs12588718 chr14:101149605 G/C cg18089426 chr14:101175970 NA -0.39 -5.95 -0.34 8.68e-9 Platelet count; CESC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg07677032 chr17:61819896 STRADA 0.44 5.85 0.34 1.44e-8 Prudent dietary pattern; CESC cis rs3096299 0.934 rs9927904 chr16:89462847 G/A cg08822215 chr16:89438651 ANKRD11 -0.43 -6.59 -0.38 2.31e-10 Multiple myeloma (IgH translocation); CESC cis rs9951602 0.703 rs2959407 chr18:76682915 A/G cg00806245 chr18:76673096 NA -0.48 -5.86 -0.34 1.35e-8 Obesity-related traits; CESC cis rs2243480 1.000 rs464895 chr7:65527106 A/G cg12463550 chr7:65579703 CRCP 0.65 5.26 0.31 3.04e-7 Diabetic kidney disease; CESC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.59 -0.38 2.36e-10 Depression; CESC cis rs6144337 1 rs6144337 chr11:47284302 TCCATGTGCCTCA/T cg25783544 chr11:47291846 MADD 0.58 6.57 0.37 2.6200000000000003e-10 Lymphocyte percentage of white cells; CESC cis rs3806843 0.966 rs1030163 chr5:140185132 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.26 -0.31 2.95e-7 Depressive symptoms (multi-trait analysis); CESC cis rs11608355 0.545 rs4766475 chr12:109908373 G/A cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs12368653 0.591 rs1552842 chr12:58012163 A/G cg18357645 chr12:58087776 OS9 -0.38 -5.36 -0.31 1.83e-7 Multiple sclerosis; CESC cis rs4523957 0.855 rs7217226 chr17:2136065 A/C cg16513277 chr17:2031491 SMG6 -0.63 -8.97 -0.48 5.52e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs1493916 0.870 rs7235698 chr18:31382486 A/G cg27147174 chr7:100797783 AP1S1 -0.51 -7.06 -0.4 1.48e-11 Life satisfaction; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg16773294 chr8:55048378 MRPL15 -0.4 -6.14 -0.35 2.92e-9 Vertical cup-disc ratio; CESC cis rs8062405 1.000 rs12443881 chr16:28841777 C/T cg08761264 chr16:28874980 SH2B1 -0.42 -5.25 -0.31 3.11e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2228479 0.702 rs78331410 chr16:89917775 C/T cg14709524 chr16:89940631 TCF25 0.88 6.04 0.35 5.27e-9 Skin colour saturation; CESC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg08470875 chr2:26401718 FAM59B 0.75 7.79 0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg02018176 chr4:1364513 KIAA1530 0.46 6.59 0.38 2.41e-10 Longevity; CESC cis rs6088580 0.602 rs6059834 chr20:33019299 A/G cg24642439 chr20:33292090 TP53INP2 0.52 6.79 0.39 7.18e-11 Glomerular filtration rate (creatinine); CESC cis rs1707322 0.721 rs10430124 chr1:46221617 C/T cg05343316 chr1:45956843 TESK2 0.51 6.36 0.36 8.88e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2270927 1.000 rs31243 chr5:75594360 A/G cg13563193 chr19:33072644 PDCD5 0.72 6.35 0.36 9.45e-10 Mean corpuscular volume; CESC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg15782153 chr7:917662 C7orf20 -0.48 -7.18 -0.4 7.25e-12 Perceived unattractiveness to mosquitoes; CESC cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.95e-9 Extrinsic epigenetic age acceleration; CESC cis rs7824557 0.510 rs2736297 chr8:11234885 C/G cg21775007 chr8:11205619 TDH -0.54 -8.13 -0.45 1.67e-14 Retinal vascular caliber; CESC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg05368731 chr17:41323189 NBR1 0.77 10.67 0.55 2.44e-22 Menopause (age at onset); CESC cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg18198730 chr1:247681584 NA 0.59 7.76 0.43 1.84e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.65 9.25 0.49 7.64e-18 Menopause (age at onset); CESC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.54 -0.37 3.08e-10 Bipolar disorder; CESC cis rs9837602 0.529 rs1688774 chr3:99521108 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.62 -9.72 -0.51 2.66e-19 Breast cancer; CESC cis rs1843834 0.539 rs2068244 chr2:225440011 A/G cg12698349 chr2:225449008 CUL3 -0.65 -8.33 -0.46 4.48e-15 IgE levels in asthmatics (D.p. specific); CESC cis rs523522 0.962 rs7488320 chr12:120981630 G/T cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs889398 0.802 rs8051168 chr16:69887274 T/A cg09409435 chr16:70099608 PDXDC2 0.41 5.05 0.3 8.37e-7 Body mass index; CESC trans rs9836484 0.778 rs12636817 chr3:78065901 C/T cg04871336 chr15:75202037 NA -0.38 -6.08 -0.35 4.11e-9 Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction); CESC cis rs12464483 0.591 rs67686878 chr2:30895044 C/T cg12454169 chr2:30669597 LCLAT1 0.58 5.96 0.34 8.18e-9 Pre-treatment pain in head and neck squamous cell carcinoma; CESC cis rs4975709 1.000 rs2279588 chr5:1878021 G/A cg12288994 chr5:1860383 NA 0.4 6.36 0.36 8.55e-10 Cardiovascular disease risk factors; CESC cis rs2242116 0.796 rs7623898 chr3:46974172 C/T cg27129171 chr3:47204927 SETD2 -0.56 -7.18 -0.4 6.9e-12 Birth weight; CESC cis rs4595586 0.525 rs11612680 chr12:39344443 A/G cg26384229 chr12:38710491 ALG10B 0.63 8.79 0.48 1.9e-16 Morning vs. evening chronotype; CESC trans rs9467711 0.606 rs9379854 chr6:26362854 T/C cg06606381 chr12:133084897 FBRSL1 -0.76 -7.01 -0.4 1.97e-11 Autism spectrum disorder or schizophrenia; CESC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg13147721 chr7:65941812 NA -0.36 -5.05 -0.3 8.35e-7 Aortic root size; CESC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg11764359 chr7:65958608 NA 0.78 11.31 0.57 1.86e-24 Aortic root size; CESC cis rs910316 0.726 rs175040 chr14:75469555 A/G cg11812906 chr14:75593930 NEK9 -0.81 -13.3 -0.63 2.89e-31 Height; CESC cis rs6493487 0.512 rs35134521 chr15:51317759 C/G cg02338191 chr15:51200825 AP4E1 0.58 5.42 0.32 1.34e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09158336 chr17:76338205 NA 0.56 6.73 0.38 1.06e-10 Gut microbiome composition (summer); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg15437133 chr10:77160907 ZNF503;C10orf41 -0.46 -6.08 -0.35 4.2e-9 Recombination measurement; CESC cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg02297831 chr4:17616191 MED28 0.6 7.51 0.42 9.14e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16456906 chr16:69373271 NIP7;COG8 -0.51 -6.36 -0.36 8.97e-10 Ulcerative colitis; CESC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg13393036 chr8:95962371 TP53INP1 -0.51 -11.08 -0.56 1.08e-23 Type 2 diabetes; CESC cis rs7927771 0.839 rs11039308 chr11:47622412 G/A cg18512352 chr11:47633146 NA -0.46 -7.02 -0.4 1.91e-11 Subjective well-being; CESC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg07507251 chr3:52567010 NT5DC2 0.41 7.13 0.4 9.51e-12 Bipolar disorder; CESC trans rs57221529 0.825 rs72703051 chr5:582997 G/A cg25482853 chr8:67687455 SGK3 1.14 10.23 0.53 6.39e-21 Lung disease severity in cystic fibrosis; CESC cis rs826838 1.000 rs11169031 chr12:39056738 T/C cg13010199 chr12:38710504 ALG10B 0.58 8.03 0.44 3.13e-14 Heart rate; CESC cis rs9640161 0.702 rs3735175 chr7:150020457 C/T cg21361702 chr7:150065534 REPIN1 0.54 6.23 0.36 1.84e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg18404041 chr3:52824283 ITIH1 -0.41 -6.75 -0.38 9.55e-11 Bipolar disorder; CESC trans rs9792269 0.735 rs72724706 chr8:129244551 C/G cg07707498 chr16:46865555 C16orf87 -0.57 -6.04 -0.35 5.08e-9 Celiac disease; CESC cis rs1005224 0.926 rs7143743 chr14:76127805 G/C cg25116370 chr14:76127843 TTLL5;C14orf1 -0.47 -6.44 -0.37 5.53e-10 Large artery stroke; CESC cis rs6545883 0.929 rs6707830 chr2:61749472 G/A cg15711740 chr2:61764176 XPO1 -0.42 -5.22 -0.31 3.65e-7 Tuberculosis; CESC cis rs2806561 0.765 rs641808 chr1:23514123 T/G cg12483005 chr1:23474871 LUZP1 0.38 6.0 0.35 6.44e-9 Height; CESC cis rs4662945 0.762 rs2406822 chr2:130218178 C/T cg05962382 chr2:130345044 NA -0.37 -5.07 -0.3 7.65e-7 Response to cytidine analogues (gemcitabine); CESC cis rs9611565 0.729 rs202654 chr22:41841034 G/A cg17376030 chr22:41985996 PMM1 -0.42 -5.11 -0.3 6.27e-7 Vitiligo; CESC cis rs4889855 0.530 rs4889872 chr17:78621306 G/A cg16591659 chr17:78472290 NA 0.32 5.24 0.31 3.22e-7 Fractional excretion of uric acid; CESC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg00149659 chr3:10157352 C3orf10 0.7 7.32 0.41 2.88e-12 Alzheimer's disease; CESC cis rs9815354 1.000 rs1994157 chr3:41897482 G/A cg03022575 chr3:42003672 ULK4 0.58 5.94 0.34 9.04e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9902453 0.817 rs2617880 chr17:28106118 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -8.47 -0.46 1.74e-15 Coffee consumption (cups per day); CESC cis rs9486719 0.843 rs2499796 chr6:96848364 A/G cg18709589 chr6:96969512 KIAA0776 0.53 5.5 0.32 8.99e-8 Migraine;Coronary artery disease; CESC cis rs9354308 1.000 rs9342503 chr6:66565436 A/G cg07460842 chr6:66804631 NA -0.51 -6.34 -0.36 1.01e-9 Metabolite levels; CESC cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg15017067 chr4:17643749 FAM184B 0.42 6.03 0.35 5.39e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs877282 0.947 rs7475589 chr10:767479 C/G cg17470449 chr10:769945 NA 0.47 5.21 0.3 3.74e-7 Uric acid levels; CESC cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg03433033 chr1:76189801 ACADM 0.68 8.23 0.45 8.33e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs8070128 0.688 rs59304093 chr17:17875407 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.13 0.45 1.68e-14 Total body bone mineral density; CESC cis rs977987 0.806 rs1030262 chr16:75491327 C/A cg03315344 chr16:75512273 CHST6 0.44 6.4 0.37 6.95e-10 Dupuytren's disease; CESC cis rs8005677 1.000 rs8005677 chr14:23376678 T/C cg25600027 chr14:23388339 RBM23 -0.41 -5.04 -0.3 8.45e-7 Cognitive ability (multi-trait analysis); CESC cis rs6732160 0.588 rs3891890 chr2:73378049 A/G cg01422370 chr2:73384389 NA 0.57 9.07 0.49 2.79e-17 Intelligence (multi-trait analysis); CESC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg13206674 chr6:150067644 NUP43 0.41 5.61 0.33 5.2100000000000003e-08 Lung cancer; CESC cis rs589448 0.535 rs12423794 chr12:69713018 G/A cg20891283 chr12:69753455 YEATS4 0.79 11.48 0.58 5.05e-25 Cerebrospinal fluid biomarker levels; CESC cis rs7216064 1.000 rs56393562 chr17:65933918 C/T cg12091567 chr17:66097778 LOC651250 -0.71 -7.28 -0.41 3.82e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg18876405 chr7:65276391 NA 0.51 6.92 0.39 3.39e-11 Aortic root size; CESC cis rs35110281 0.805 rs4818843 chr21:45006607 C/T cg04455712 chr21:45112962 RRP1B 0.36 5.23 0.31 3.41e-7 Mean corpuscular volume; CESC cis rs476633 0.691 rs28735224 chr15:41537539 C/T cg18705301 chr15:41695430 NDUFAF1 -0.5 -7.27 -0.41 3.93e-12 Glomerular filtration rate (creatinine); CESC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg04775059 chr7:64541387 NA -0.44 -5.46 -0.32 1.12e-7 Calcium levels; CESC cis rs2737618 0.674 rs2821332 chr1:200085714 A/T cg21825944 chr1:200113062 NR5A2 -0.47 -7.28 -0.41 3.77e-12 Uric acid levels; CESC cis rs5753618 0.561 rs5749265 chr22:31796897 A/C cg13145458 chr22:31556086 RNF185 -0.5 -5.96 -0.34 7.96e-9 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24024291 chr19:6740123 TRIP10 0.61 7.08 0.4 1.27e-11 Gut microbiome composition (summer); CESC cis rs6598955 0.724 rs10902737 chr1:26635716 G/A cg04990556 chr1:26633338 UBXN11 -0.78 -10.94 -0.56 3.11e-23 Obesity-related traits; CESC cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg03467027 chr4:99064603 C4orf37 0.45 5.61 0.33 5.13e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9486719 1.000 rs11153018 chr6:96956137 G/A cg18709589 chr6:96969512 KIAA0776 -0.57 -6.26 -0.36 1.53e-9 Migraine;Coronary artery disease; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg24503407 chr1:205819492 PM20D1 0.96 17.97 0.74 8.92e-48 Menarche (age at onset); CESC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg22105103 chr4:187893119 NA 0.5 7.27 0.41 4.07e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs3092073 0.624 rs3848714 chr20:44547176 T/C cg00125455 chr20:44574271 PCIF1 0.37 5.87 0.34 1.28e-8 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15020732 chr15:85144228 ZSCAN2 -0.47 -6.16 -0.35 2.62e-9 Fibrinogen levels; CESC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg22968622 chr17:43663579 NA 1.23 17.24 0.73 3.49e-45 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7843479 0.601 rs10453141 chr8:21847235 T/C cg17168535 chr8:21777572 XPO7 0.73 11.44 0.57 6.96e-25 Mean corpuscular volume; CESC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg16680214 chr1:154839983 KCNN3 -0.44 -6.76 -0.38 8.73e-11 Prostate cancer; CESC cis rs4604732 0.527 rs7539082 chr1:247627260 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.2 0.4 6.34e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6088580 0.634 rs6088498 chr20:33020446 A/G cg06115741 chr20:33292138 TP53INP2 0.48 6.47 0.37 4.84e-10 Glomerular filtration rate (creatinine); CESC cis rs950169 0.922 rs4842941 chr15:84831312 G/C cg17507749 chr15:85114479 UBE2QP1 -0.55 -6.25 -0.36 1.66e-9 Schizophrenia; CESC cis rs911555 0.755 rs55742283 chr14:103942965 A/G cg12935359 chr14:103987150 CKB 0.67 9.78 0.52 1.73e-19 Intelligence (multi-trait analysis); CESC cis rs11190604 1.000 rs4917901 chr10:102201773 A/C cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs372883 0.600 rs1312254 chr21:30695401 A/G cg24692254 chr21:30365293 RNF160 -0.58 -7.27 -0.41 4.04e-12 Pancreatic cancer; CESC cis rs6582630 0.599 rs11181807 chr12:38403763 G/A cg26384229 chr12:38710491 ALG10B -0.46 -6.2 -0.36 2.14e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg23281280 chr6:28129359 ZNF389 0.59 7.96 0.44 5.16e-14 Depression; CESC cis rs870825 0.616 rs41278579 chr4:185622402 A/G cg04058563 chr4:185651563 MLF1IP 0.64 6.48 0.37 4.51e-10 Blood protein levels; CESC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.2e-17 Prudent dietary pattern; CESC cis rs919433 0.854 rs787994 chr2:198223121 T/C cg03934865 chr2:198174659 NA 0.43 6.37 0.36 8.42e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg21573476 chr21:45109991 RRP1B -0.5 -6.86 -0.39 4.89e-11 Mean corpuscular volume; CESC cis rs113835537 0.529 rs17580784 chr11:66214859 T/A cg22134325 chr11:66188745 NPAS4 0.42 6.35 0.36 9.18e-10 Airway imaging phenotypes; CESC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg04369109 chr6:150039330 LATS1 -0.4 -5.4 -0.31 1.48e-7 Lung cancer; CESC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.93 0.34 9.24e-9 Tonsillectomy; CESC cis rs7267979 0.868 rs6138546 chr20:25216534 G/A cg08601574 chr20:25228251 PYGB 0.45 6.5 0.37 4.01e-10 Liver enzyme levels (alkaline phosphatase); CESC cis rs4764124 0.646 rs11610238 chr12:14975721 C/T cg19759883 chr12:14956454 WBP11;C12orf60 0.58 8.74 0.47 2.79e-16 Pubertal anthropometrics; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg01062786 chr14:20929651 TMEM55B 0.47 6.65 0.38 1.63e-10 Bronchopulmonary dysplasia; CESC cis rs1882538 0.564 rs12707090 chr7:133115163 G/A cg10665199 chr7:133106180 EXOC4 0.58 7.77 0.43 1.75e-13 Intelligence (multi-trait analysis); CESC cis rs1062177 0.901 rs1549622 chr5:151266049 A/G cg12924095 chr5:151150029 G3BP1 0.5 6.6 0.38 2.21e-10 Preschool internalizing problems; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15876657 chr6:144416565 SF3B5 -0.52 -6.46 -0.37 5.01e-10 Ulcerative colitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11078198 chr14:21572134 ZNF219 0.5 6.32 0.36 1.08e-9 Gut microbiota (bacterial taxa); CESC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 12.95 0.62 4.58e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1941023 0.503 rs2233238 chr11:60145441 G/C cg08716584 chr11:60157161 MS4A7 -0.56 -9.41 -0.5 2.55e-18 Congenital heart disease (maternal effect); CESC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg05890377 chr2:74357713 NA 0.79 10.23 0.53 6.62e-21 Gestational age at birth (maternal effect); CESC cis rs7666738 0.606 rs4637413 chr4:99088151 A/G cg24818145 chr4:99064322 C4orf37 0.39 5.13 0.3 5.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg00074818 chr8:8560427 CLDN23 0.38 5.41 0.32 1.39e-7 Obesity-related traits; CESC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg15145296 chr3:125709740 NA -0.5 -5.37 -0.31 1.74e-7 Blood pressure (smoking interaction); CESC cis rs11098499 0.866 rs12510451 chr4:120289143 C/T cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs2204008 0.571 rs8175738 chr12:38311234 C/T cg26384229 chr12:38710491 ALG10B -0.46 -6.03 -0.35 5.42e-9 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16749093 chr11:65352605 EHBP1L1 -0.55 -6.05 -0.35 4.82e-9 Gut microbiome composition (summer); CESC trans rs875971 1.000 rs6460295 chr7:65882728 T/C cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.77e-9 Aortic root size; CESC cis rs55788414 0.932 rs9940095 chr16:81182108 A/G cg06400318 chr16:81190750 PKD1L2 -0.59 -7.04 -0.4 1.62e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.7 -0.38 1.24e-10 Life satisfaction; CESC cis rs11148252 0.553 rs9536236 chr13:53255012 T/A cg00495681 chr13:53174319 NA 0.59 8.05 0.44 2.84e-14 Lewy body disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10822418 chr8:61430157 RAB2A -0.49 -6.4 -0.37 7.17e-10 Fibrinogen levels; CESC cis rs7827545 1.000 rs1372659 chr8:135566779 T/A cg17885191 chr8:135476712 NA 0.48 6.28 0.36 1.35e-9 Hypertension (SNP x SNP interaction); CESC cis rs793571 0.566 rs1648532 chr15:59076778 G/C cg05156742 chr15:59063176 FAM63B 0.63 8.3 0.45 5.26e-15 Schizophrenia; CESC cis rs6977955 0.627 rs1513275 chr7:28259233 C/T cg23620719 chr7:28220237 JAZF1 -0.49 -5.53 -0.32 7.67e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs9814567 0.762 rs13075332 chr3:134329836 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.47 5.7 0.33 3.21e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6088590 0.523 rs6058084 chr20:33183804 C/T cg06115741 chr20:33292138 TP53INP2 0.52 6.6 0.38 2.21e-10 Coronary artery disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04856952 chr22:29664439 EWSR1;RHBDD3 -0.49 -6.13 -0.35 3.11e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09161758 chr1:205720516 NUCKS1 -0.56 -6.39 -0.37 7.55e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg04944784 chr2:26401820 FAM59B 0.83 9.32 0.5 4.83e-18 Gut microbiome composition (summer); CESC cis rs10927875 0.578 rs10927859 chr1:16141862 C/T cg05821634 chr1:16164109 FLJ37453 0.34 5.04 0.3 8.45e-7 Dilated cardiomyopathy; CESC cis rs3733585 0.699 rs6449202 chr4:9974043 T/C cg11266682 chr4:10021025 SLC2A9 -0.58 -10.92 -0.56 3.75e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7818688 0.697 rs11787303 chr8:95972864 C/T cg16049864 chr8:95962084 TP53INP1 0.59 5.82 0.34 1.68e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.89 7.76 0.43 1.79e-13 Initial pursuit acceleration; CESC cis rs2404602 0.735 rs2957614 chr15:76696635 C/T cg00316803 chr15:76480434 C15orf27 -0.34 -5.05 -0.3 8.18e-7 Blood metabolite levels; CESC cis rs117623576 0.941 rs7912584 chr10:32416623 C/T cg03047570 chr10:32398778 NA -0.82 -8.41 -0.46 2.48e-15 Anti-saccade response; CESC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg12034118 chr1:209979487 IRF6 0.47 5.8 0.34 1.91e-8 Cleft lip with or without cleft palate; CESC cis rs9908102 0.770 rs73300518 chr17:12914795 G/C cg26162695 chr17:12921313 ELAC2 0.53 5.73 0.33 2.68e-8 Schizophrenia; CESC cis rs6484504 0.576 rs208072 chr11:31141288 A/G cg14844989 chr11:31128820 NA 0.4 5.3 0.31 2.45e-7 Red blood cell count; CESC cis rs11098499 0.690 rs34818745 chr4:120257055 T/C cg09307838 chr4:120376055 NA 0.91 12.45 0.61 2.44e-28 Corneal astigmatism; CESC cis rs1050631 1.000 rs1789504 chr18:33696772 A/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.44 5.65 0.33 4.2e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs7582720 0.511 rs116219813 chr2:204081675 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.18 0.4 7.05e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06102153 chr16:4674926 MGRN1 0.56 6.34 0.36 1.01e-9 Gut microbiome composition (summer); CESC cis rs6860806 0.531 rs274556 chr5:131722075 A/G cg07395648 chr5:131743802 NA 0.43 5.66 0.33 3.92e-8 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10164987 chr2:63816052 MDH1;C2orf86 0.54 6.75 0.38 9.53e-11 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs2072794 chr22:39150543 G/T cg06544989 chr22:39130855 UNC84B 0.5 8.78 0.47 2.12e-16 Menopause (age at onset); CESC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg03806693 chr22:41940476 POLR3H -1.22 -14.63 -0.67 5.98e-36 Vitiligo; CESC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg14926445 chr8:58193284 C8orf71 -0.48 -5.3 -0.31 2.39e-7 Developmental language disorder (linguistic errors); CESC cis rs1008375 1.000 rs2286771 chr4:17643848 G/A cg02297831 chr4:17616191 MED28 0.53 6.71 0.38 1.2e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2290720 0.896 rs7980431 chr12:101707067 A/G cg22051763 chr12:101673672 UTP20 -0.45 -5.35 -0.31 1.95e-7 Brain structure (hippocampal volume); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07956857 chr9:106761676 NA -0.52 -6.28 -0.36 1.36e-9 Gut microbiome composition (summer); CESC cis rs71277158 0.688 rs59249820 chr3:169755545 C/T cg04067573 chr3:169899625 PHC3 0.53 5.4 0.31 1.48e-7 Prostate cancer; CESC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.45 -0.32 1.13e-7 Aortic root size; CESC cis rs9467711 0.606 rs9358935 chr6:26369587 A/G cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC cis rs926938 0.527 rs6680112 chr1:115548915 G/C cg12756093 chr1:115239321 AMPD1 0.44 6.11 0.35 3.53e-9 Autism; CESC cis rs9487051 0.698 rs35757653 chr6:109644599 A/C cg01475377 chr6:109611718 NA -0.4 -5.39 -0.31 1.54e-7 Reticulocyte fraction of red cells; CESC cis rs4604732 0.812 rs6663238 chr1:247624971 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 -0.35 -5.05 -0.3 8.4e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs3091242 0.933 rs34933589 chr1:25788198 T/C cg03538708 chr1:25844672 NA 0.37 5.6 0.33 5.26e-8 Erythrocyte sedimentation rate; CESC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.74 7.77 0.43 1.75e-13 Platelet count; CESC cis rs10779751 1.000 rs11121698 chr1:11267283 C/T cg08854313 chr1:11322531 MTOR 0.91 14.23 0.66 1.56e-34 Body mass index; CESC cis rs10242455 0.702 rs41385645 chr7:98974038 A/T cg18809830 chr7:99032528 PTCD1 -0.68 -5.08 -0.3 7.02e-7 Blood metabolite levels; CESC cis rs3096299 0.869 rs748941 chr16:89440754 T/A cg08392591 chr16:89556376 ANKRD11 0.41 5.23 0.31 3.42e-7 Multiple myeloma (IgH translocation); CESC cis rs11920090 0.872 rs5400 chr3:170732300 G/A cg09710316 chr3:170744871 SLC2A2 0.45 5.4 0.32 1.46e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs9303401 0.659 rs17222691 chr17:56771096 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.04 11.66 0.58 1.27e-25 Cognitive test performance; CESC cis rs11098499 0.691 rs28396837 chr4:120271541 G/A cg09307838 chr4:120376055 NA 0.77 10.19 0.53 8.72e-21 Corneal astigmatism; CESC cis rs12618769 0.597 rs3769727 chr2:99103318 C/T cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs6542838 0.609 rs13028500 chr2:99528296 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -5.19 -0.3 4.16e-7 Fear of minor pain; CESC cis rs7264396 0.887 rs224360 chr20:34059675 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.41 5.08 0.3 7.15e-7 Total cholesterol levels; CESC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg25985355 chr7:65971099 NA 0.31 5.09 0.3 6.82e-7 Aortic root size; CESC cis rs6499255 0.904 rs12447883 chr16:69722797 T/C cg15192750 chr16:69999425 NA 0.53 6.13 0.35 3.24e-9 IgE levels; CESC cis rs2932538 0.961 rs4240534 chr1:113175429 T/A cg22162597 chr1:113214053 CAPZA1 -0.58 -7.45 -0.42 1.3e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs11166629 1.000 rs1036820 chr8:135646571 C/T cg27224718 chr8:135614730 ZFAT -0.5 -6.55 -0.37 2.93e-10 Smoking quantity; CESC cis rs7084402 1.000 rs6481400 chr10:60268783 T/C cg07615347 chr10:60278583 BICC1 -0.57 -8.72 -0.47 3.03e-16 Refractive error; CESC cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg23711669 chr6:146136114 FBXO30 1.02 16.0 0.7 8.93e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg09737314 chr17:6899359 ALOX12 0.46 7.9 0.44 7.33e-14 Tonsillectomy; CESC cis rs72781680 1.000 rs72781680 chr2:24238928 C/T cg20701182 chr2:24300061 SF3B14 0.82 6.96 0.39 2.66e-11 Lymphocyte counts; CESC cis rs6964587 0.610 rs4729008 chr7:91457054 G/T cg17063962 chr7:91808500 NA 0.42 5.77 0.33 2.22e-8 Breast cancer; CESC cis rs7267979 1.000 rs2259926 chr20:25281733 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs2625529 0.730 rs982752 chr15:72145937 C/T cg16672083 chr15:72433130 SENP8 -0.45 -6.55 -0.37 2.91e-10 Red blood cell count; CESC cis rs28374715 0.580 rs8030228 chr15:41636867 A/G cg20272979 chr15:41787780 ITPKA 0.4 5.07 0.3 7.38e-7 Ulcerative colitis; CESC trans rs9388451 0.626 rs1343115 chr6:126069817 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.66 -9.31 -0.5 4.92e-18 Brugada syndrome; CESC cis rs7223966 1.000 rs8077265 chr17:61732727 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.56 -0.32 6.64e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1505368 0.567 rs972491 chr2:213316573 A/G cg16329650 chr2:213403929 ERBB4 -0.49 -7.48 -0.42 1.11e-12 Symmetrical dimethylarginine levels; CESC cis rs9914544 1.000 rs28436199 chr17:18751730 C/T cg26378065 chr17:18585709 ZNF286B 0.44 5.46 0.32 1.07e-7 Educational attainment (years of education); CESC cis rs7100689 0.646 rs1340374 chr10:82129114 C/T cg00277334 chr10:82204260 NA -0.58 -7.6 -0.42 5.01e-13 Post bronchodilator FEV1; CESC cis rs6977660 0.652 rs58559474 chr7:19751569 C/T cg05791153 chr7:19748676 TWISTNB 0.83 7.38 0.41 2.1e-12 Thyroid stimulating hormone; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03936012 chr13:37633916 FAM48A 0.57 6.06 0.35 4.63e-9 Gut microbiome composition (summer); CESC cis rs10899021 0.920 rs11236171 chr11:74317518 C/T cg25880958 chr11:74394337 NA -0.78 -8.14 -0.45 1.53e-14 Response to metformin (IC50); CESC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg23161317 chr6:28129485 ZNF389 0.46 6.04 0.35 5.25e-9 Parkinson's disease; CESC cis rs73206853 0.697 rs56084592 chr12:110577910 T/A cg12870014 chr12:110450643 ANKRD13A 0.65 5.58 0.32 5.95e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs12956009 0.518 rs4574017 chr18:44891703 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 6.81 0.39 6.63e-11 Educational attainment (years of education); CESC cis rs2249694 0.960 rs6537613 chr10:135412414 T/G cg19469447 chr10:135341870 CYP2E1 0.36 5.07 0.3 7.39e-7 Obesity-related traits; CESC cis rs12477438 0.748 rs6712773 chr2:99585781 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs4243830 0.850 rs12030607 chr1:6601007 T/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.97 9.8 0.52 1.46e-19 Body mass index; CESC cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg03467027 chr4:99064603 C4orf37 0.45 5.61 0.33 4.97e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7312774 0.618 rs7304621 chr12:107325888 C/T cg16260113 chr12:107380972 MTERFD3 0.78 7.11 0.4 1.05e-11 Severe influenza A (H1N1) infection; CESC cis rs12410462 0.681 rs76191945 chr1:227673919 A/G cg23173402 chr1:227635558 NA 0.7 6.02 0.35 5.94e-9 Major depressive disorder; CESC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.31e-9 Developmental language disorder (linguistic errors); CESC trans rs1814175 0.817 rs28544182 chr11:50049577 G/T cg15704280 chr7:45808275 SEPT13 -1.05 -21.42 -0.8 9.36e-60 Height; CESC trans rs11098499 0.954 rs7656252 chr4:120404268 T/C cg25214090 chr10:38739885 LOC399744 0.72 10.18 0.53 9.16e-21 Corneal astigmatism; CESC cis rs11792861 0.962 rs3750454 chr9:111801325 C/G cg13535736 chr9:111863775 C9orf5 0.49 6.47 0.37 4.84e-10 Menarche (age at onset); CESC cis rs1797885 0.934 rs1797874 chr3:12529592 C/A cg26432171 chr3:12704882 RAF1 -0.48 -5.97 -0.34 7.75e-9 Immature fraction of reticulocytes; CESC cis rs7589342 0.501 rs7602971 chr2:106440675 G/A cg16077055 chr2:106428750 NCK2 0.4 6.28 0.36 1.35e-9 Addiction; CESC cis rs1801251 0.896 rs921054 chr2:233694673 G/A cg08000102 chr2:233561755 GIGYF2 -0.72 -11.37 -0.57 1.16e-24 Coronary artery disease; CESC cis rs7659604 0.521 rs4833234 chr4:122694799 T/C cg19748678 chr4:122722346 EXOSC9 -0.45 -5.77 -0.33 2.15e-8 Type 2 diabetes; CESC cis rs3617 0.591 rs2276823 chr3:52869263 C/A cg07507251 chr3:52567010 NT5DC2 -0.32 -5.43 -0.32 1.31e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg10150615 chr22:24372951 LOC391322 -0.44 -5.05 -0.3 8.22e-7 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs17253792 0.822 rs77197405 chr14:56159662 T/A cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.73 0.33 2.74e-8 Putamen volume; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg01263691 chr6:52535928 TMEM14A 0.51 6.23 0.36 1.83e-9 Psoriatic arthritis; CESC cis rs6977660 0.507 rs72591450 chr7:19775480 A/G cg07541023 chr7:19748670 TWISTNB 0.8 7.2 0.4 6.34e-12 Thyroid stimulating hormone; CESC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg04944784 chr2:26401820 FAM59B -0.5 -5.82 -0.34 1.66e-8 Gut microbiome composition (summer); CESC cis rs561341 0.700 rs6505266 chr17:30225813 G/A cg13647721 chr17:30228624 UTP6 0.82 10.56 0.54 5.47e-22 Hip circumference adjusted for BMI; CESC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.35 0.54 2.67e-21 Prudent dietary pattern; CESC cis rs2425143 1.000 rs6060572 chr20:34294015 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.66 6.01 0.35 6.17e-9 Blood protein levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14788749 chr22:35937309 RASD2 -0.48 -6.2 -0.36 2.2e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8009147 1 rs8009147 chr14:104264662 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.09 -0.4 1.2e-11 Autism spectrum disorder or schizophrenia; CESC cis rs4722166 0.597 rs1554606 chr7:22768707 T/G cg13104385 chr7:22767384 IL6 0.36 5.33 0.31 2.11e-7 Lung cancer; CESC cis rs9527 0.590 rs10883839 chr10:104920341 A/G cg04362960 chr10:104952993 NT5C2 0.46 5.36 0.31 1.79e-7 Arsenic metabolism; CESC cis rs7246657 0.943 rs10403613 chr19:37844306 C/T cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16561543 chr14:105714843 BRF1;BTBD6 0.55 6.64 0.38 1.74e-10 Gut microbiome composition (summer); CESC cis rs2346177 0.542 rs6718875 chr2:46687982 G/T cg02822958 chr2:46747628 ATP6V1E2 0.44 5.47 0.32 1.03e-7 HDL cholesterol; CESC cis rs950169 0.649 rs12911612 chr15:84691014 T/C cg17507749 chr15:85114479 UBE2QP1 0.58 5.77 0.33 2.21e-8 Schizophrenia; CESC cis rs4242434 0.698 rs10104039 chr8:22538384 A/G cg03733263 chr8:22462867 KIAA1967 -0.76 -11.82 -0.59 3.46e-26 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC trans rs10463316 0.894 rs6579865 chr5:150762335 A/C cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC trans rs10506458 0.915 rs2013042 chr12:63394211 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.24 -15.9 -0.7 2.02e-40 Hemostatic factors and hematological phenotypes; CESC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg18876405 chr7:65276391 NA -0.52 -7.15 -0.4 8.38e-12 Aortic root size; CESC cis rs425277 0.565 rs3128293 chr1:2065339 A/G cg23803603 chr1:2058230 PRKCZ -0.31 -5.08 -0.3 7.14e-7 Height; CESC cis rs1707322 1.000 rs785519 chr1:46568562 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.63 -0.33 4.67e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs5769765 0.908 rs9616396 chr22:50317825 T/C cg02269571 chr22:50332266 NA -0.57 -6.6 -0.38 2.28e-10 Schizophrenia; CESC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.59 -0.38 2.31e-10 Life satisfaction; CESC cis rs9596863 1.000 rs1155438 chr13:54460544 G/T ch.13.53330881F chr13:54432880 NA -0.67 -5.68 -0.33 3.5e-8 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs12220238 0.915 rs11001014 chr10:76128832 A/G cg19889307 chr10:75911429 ADK;AP3M1 -0.55 -5.25 -0.31 3.05e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs4727027 0.866 rs1405124 chr7:148779618 C/T cg23158103 chr7:148848205 ZNF398 -0.41 -6.62 -0.38 1.97e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7772486 0.790 rs6926076 chr6:146232804 C/T cg05347473 chr6:146136440 FBXO30 -0.55 -7.05 -0.4 1.57e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs896543 1.000 rs896543 chr2:237509207 A/G cg25295825 chr2:237489920 CXCR7 -0.56 -7.45 -0.42 1.33e-12 Alcohol dependence (age at onset); CESC cis rs7923609 0.812 rs10761753 chr10:65161903 G/A cg01631684 chr10:65280961 REEP3 -0.44 -5.46 -0.32 1.09e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03664139 chr6:101329504 ASCC3 -0.47 -6.72 -0.38 1.11e-10 Gambling; CESC cis rs7914558 0.966 rs1890185 chr10:104748718 A/G cg04362960 chr10:104952993 NT5C2 0.46 6.04 0.35 5.22e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs546131 0.890 rs496558 chr11:34826425 C/T cg11058730 chr11:34937778 PDHX;APIP 0.49 6.25 0.36 1.64e-9 Lung disease severity in cystic fibrosis; CESC cis rs1865721 0.771 rs62092763 chr18:73128623 T/G cg26385618 chr18:73139727 C18orf62 -0.52 -8.29 -0.45 5.91e-15 Intelligence; CESC cis rs4132509 0.625 rs1417121 chr1:243669350 G/C cg21452805 chr1:244014465 NA 0.4 5.09 0.3 6.74e-7 RR interval (heart rate); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20999565 chr14:68265668 ZFYVE26 -0.51 -6.37 -0.36 8.15e-10 Asthma; CESC cis rs5758659 0.845 rs5758645 chr22:42598951 T/G cg15557168 chr22:42548783 NA -0.49 -7.65 -0.43 3.71e-13 Cognitive function; CESC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.47 -0.32 1.06e-7 Aortic root size; CESC cis rs12148488 0.738 rs4886417 chr15:75330159 T/G cg17294928 chr15:75287854 SCAMP5 0.56 7.04 0.4 1.67e-11 Caffeine consumption; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04426326 chr15:59499030 LDHAL6B;MYO1E -0.57 -6.31 -0.36 1.14e-9 Gut microbiome composition (summer); CESC cis rs6088590 1.000 rs2378256 chr20:33292127 G/C cg24642439 chr20:33292090 TP53INP2 0.87 12.01 0.59 8.2e-27 Coronary artery disease; CESC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg02569458 chr12:86230093 RASSF9 0.57 8.34 0.46 4.13e-15 Major depressive disorder; CESC cis rs710216 0.843 rs10890232 chr1:43416514 C/T cg07803811 chr1:43423981 SLC2A1 0.46 5.2 0.3 3.94e-7 Red cell distribution width; CESC cis rs7665939 1.000 rs72709217 chr4:190113079 C/T cg09826759 chr4:190284978 NA -0.71 -7.06 -0.4 1.46e-11 Amyotrophic lateral sclerosis; CESC cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg27478167 chr7:817139 HEATR2 -0.51 -5.54 -0.32 7.4e-8 Cerebrospinal P-tau181p levels; CESC cis rs3733585 0.699 rs7683283 chr4:9969974 T/C cg00071950 chr4:10020882 SLC2A9 -0.69 -11.44 -0.57 6.98e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8103278 1.000 rs8108590 chr19:46301620 A/G cg14061069 chr19:46274453 DMPK -0.37 -5.07 -0.3 7.38e-7 Coronary artery disease; CESC cis rs854765 0.583 rs4925129 chr17:17807186 A/G cg04398451 chr17:18023971 MYO15A -0.64 -8.72 -0.47 3.17e-16 Total body bone mineral density; CESC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.89 0.52 7.53e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6840258 1.000 rs114701347 chr4:87965001 C/T cg08197287 chr4:87952173 AFF1 -0.39 -5.34 -0.31 1.96e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs2072499 0.931 rs1052053 chr1:156202173 A/G cg24450063 chr1:156163899 SLC25A44 0.94 17.22 0.73 4.18e-45 Testicular germ cell tumor; CESC cis rs9840812 0.728 rs12635723 chr3:136300732 A/G cg15507776 chr3:136538369 TMEM22 0.44 5.32 0.31 2.21e-7 Fibrinogen levels; CESC cis rs3784262 0.900 rs12911071 chr15:58314848 G/A cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.05 -0.3 8.08e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs3015497 0.603 rs1845416 chr14:51071600 A/G cg26011998 chr14:51135199 SAV1 -0.47 -5.31 -0.31 2.36e-7 Mean platelet volume; CESC cis rs7998202 0.614 rs282573 chr13:113362105 G/A cg02820901 chr13:113351484 ATP11A 0.65 5.53 0.32 7.54e-8 Glycated hemoglobin levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23901904 chr1:10855062 CASZ1 -0.47 -6.21 -0.36 2.07e-9 Height; CESC cis rs6831352 0.838 rs2851250 chr4:100044113 G/C cg12011299 chr4:100065546 ADH4 0.59 6.66 0.38 1.56e-10 Alcohol dependence; CESC cis rs3859192 0.539 rs2302774 chr17:38183090 G/T cg17467752 chr17:38218738 THRA -0.45 -5.91 -0.34 1.07e-8 White blood cell count; CESC trans rs459571 0.804 rs448918 chr9:136885979 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.64 -8.09 -0.45 2.13e-14 Platelet distribution width; CESC cis rs6951245 0.507 rs10227709 chr7:1180515 T/G cg24642844 chr7:1081250 C7orf50 -0.45 -6.35 -0.36 9.5e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs3816587 0.839 rs6840730 chr4:25422976 G/A cg01822600 chr1:245751692 KIF26B 0.41 6.04 0.35 5.19e-9 Rheumatoid arthritis; CESC cis rs367943 0.966 rs451425 chr5:112808637 A/G cg12552261 chr5:112820674 MCC -0.62 -7.85 -0.43 1.05e-13 Type 2 diabetes; CESC cis rs12474201 0.862 rs7562173 chr2:46976217 C/G cg06386533 chr2:46925753 SOCS5 -0.83 -11.22 -0.57 3.72e-24 Height; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17677112 chr7:77428730 PHTF2;TMEM60 0.45 6.04 0.35 5.23e-9 Systemic lupus erythematosus; CESC cis rs72781680 0.898 rs6712175 chr2:24023431 T/G cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs7707921 0.602 rs10514231 chr5:81307412 C/T cg15871215 chr5:81402204 ATG10 0.47 6.61 0.38 2.12e-10 Breast cancer; CESC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg24829409 chr8:58192753 C8orf71 -0.74 -9.68 -0.51 3.6e-19 Developmental language disorder (linguistic errors); CESC cis rs864537 0.590 rs1214596 chr1:167427170 A/T cg22356347 chr1:167427500 CD247 0.41 8.36 0.46 3.52e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC trans rs7615952 0.599 rs7652883 chr3:125707977 T/G cg07211511 chr3:129823064 LOC729375 -0.55 -6.35 -0.36 9.41e-10 Blood pressure (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26048388 chr10:7829683 ATP5C1;KIN 0.55 6.32 0.36 1.1e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06239170 chr6:657134 HUS1B;EXOC2 -0.69 -7.76 -0.43 1.83e-13 Gut microbiome composition (summer); CESC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg03188948 chr7:1209495 NA 0.57 6.61 0.38 2.06e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7586879 0.609 rs7608976 chr2:25075281 G/A cg01884057 chr2:25150051 NA 0.37 7.18 0.4 7.06e-12 Body mass index; CESC cis rs4423214 0.840 rs1792235 chr11:71181473 C/T cg05163923 chr11:71159392 DHCR7 -0.65 -7.77 -0.43 1.71e-13 Vitamin D levels; CESC cis rs6866344 0.568 rs10516147 chr5:178094484 A/G cg10224037 chr5:178157518 ZNF354A 0.54 5.96 0.34 8.1e-9 Neutrophil percentage of white cells; CESC cis rs8135665 0.600 rs8139025 chr22:38450881 G/C cg13116946 chr22:38479732 SLC16A8 0.43 5.26 0.31 2.92e-7 Advanced age-related macular degeneration;Age-related macular degeneration; CESC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 11.52 0.58 3.61e-25 Alzheimer's disease; CESC cis rs10129255 0.646 rs55995061 chr14:107207547 A/G cg07958169 chr14:107095056 NA -0.51 -7.43 -0.42 1.49e-12 Kawasaki disease; CESC cis rs258892 0.895 rs34658 chr5:72148496 A/G cg21869765 chr5:72125136 TNPO1 0.44 5.55 0.32 6.92e-8 Small cell lung carcinoma; CESC cis rs8114671 0.562 rs4911449 chr20:33512236 T/G cg06115741 chr20:33292138 TP53INP2 0.46 5.58 0.32 6.06e-8 Height; CESC cis rs10129255 0.957 rs6576233 chr14:107195477 G/A cg07958169 chr14:107095056 NA -0.46 -6.31 -0.36 1.19e-9 Kawasaki disease; CESC cis rs7640424 0.649 rs13082569 chr3:107870835 A/C cg09227934 chr3:107805635 CD47 0.43 5.59 0.32 5.69e-8 Body mass index; CESC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg06456125 chr7:65229604 NA 0.46 5.83 0.34 1.6e-8 Aortic root size; CESC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg06808227 chr14:105710500 BRF1 -0.62 -7.91 -0.44 7.23e-14 Mean platelet volume;Platelet distribution width; CESC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg03647317 chr4:187891568 NA -0.39 -5.72 -0.33 2.84e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs11758351 0.660 rs16891455 chr6:26230485 G/A cg01420254 chr6:26195488 NA 0.77 8.49 0.46 1.48e-15 Gout;Renal underexcretion gout; CESC cis rs34421088 0.585 rs1390950 chr8:11595829 C/T cg13293535 chr8:11597251 GATA4 0.27 5.1 0.3 6.54e-7 Neuroticism; CESC trans rs7156960 0.866 rs935331 chr14:76699532 A/G cg18786782 chr3:13936527 NA -0.43 -6.32 -0.36 1.1e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg06784218 chr1:46089804 CCDC17 -0.28 -5.09 -0.3 6.71e-7 High light scatter reticulocyte count; CESC cis rs2991971 0.810 rs781058 chr1:45935056 C/G cg15605315 chr1:45957053 TESK2 -0.38 -5.27 -0.31 2.82e-7 High light scatter reticulocyte count; CESC cis rs6582630 0.621 rs10880656 chr12:38571220 A/C cg26384229 chr12:38710491 ALG10B -0.42 -5.58 -0.32 5.84e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs4820539 0.932 rs3788349 chr22:23467950 A/G cg14186256 chr22:23484241 RTDR1 0.82 14.59 0.67 8.64e-36 Bone mineral density; CESC cis rs7503807 0.688 rs12952285 chr17:78596158 C/G cg09596252 chr17:78655493 RPTOR -0.37 -5.22 -0.31 3.62e-7 Obesity; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg16406212 chr2:24163862 UBXN2A 0.45 6.31 0.36 1.15e-9 Positive affect; CESC cis rs7608623 0.804 rs11675585 chr2:24237180 T/C cg08917208 chr2:24149416 ATAD2B -0.44 -5.49 -0.32 9.22e-8 Obesity-related traits; CESC cis rs2243480 1.000 rs316331 chr7:65604622 A/G cg12463550 chr7:65579703 CRCP -0.66 -5.15 -0.3 5.09e-7 Diabetic kidney disease; CESC trans rs3780486 0.846 rs10813960 chr9:33180362 C/T cg04842962 chr6:43655489 MRPS18A 0.84 12.22 0.6 1.58e-27 IgG glycosylation; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00615915 chr18:61637299 SERPINB8 0.45 6.23 0.36 1.87e-9 Systemic lupus erythematosus; CESC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg04553112 chr3:125709451 NA -0.55 -5.85 -0.34 1.44e-8 Blood pressure (smoking interaction); CESC cis rs11098499 0.954 rs1022145 chr4:120230979 A/G cg24375607 chr4:120327624 NA 0.46 5.56 0.32 6.43e-8 Corneal astigmatism; CESC cis rs116095464 1.000 rs6555159 chr5:311562 G/A cg10591111 chr5:226296 SDHA -0.59 -5.43 -0.32 1.3e-7 Breast cancer; CESC cis rs9913156 0.793 rs55682338 chr17:4582183 G/A cg19197139 chr17:4613644 ARRB2 0.92 10.4 0.54 1.85e-21 Lymphocyte counts; CESC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg22903471 chr2:27725779 GCKR -0.5 -7.15 -0.4 8.25e-12 Menopause (age at onset); CESC cis rs72627509 0.904 rs17081933 chr4:57822869 T/A cg26694713 chr4:57773883 REST 0.54 5.26 0.31 3e-7 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg21770322 chr7:97807741 LMTK2 0.55 8.08 0.44 2.32e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs17655565 0.581 rs17657609 chr12:52763601 C/T cg00777198 chr12:52828273 KRT75 0.35 5.07 0.3 7.59e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs1153858 1.000 rs1153858 chr15:45652703 A/G cg21132104 chr15:45694354 SPATA5L1 -0.75 -9.89 -0.52 8.06e-20 Homoarginine levels; CESC trans rs1814175 0.650 rs6486000 chr11:49659090 T/A cg03929089 chr4:120376271 NA -0.85 -11.91 -0.59 1.78e-26 Height; CESC cis rs798554 0.704 rs709282 chr7:2769921 G/A cg13628971 chr7:2884303 GNA12 0.41 5.41 0.32 1.42e-7 Height; CESC cis rs11098499 0.954 rs10034623 chr4:120397829 G/A cg09307838 chr4:120376055 NA 0.94 14.09 0.65 4.83e-34 Corneal astigmatism; CESC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg09177884 chr7:1199841 ZFAND2A -0.59 -7.61 -0.42 4.93e-13 Longevity;Endometriosis; CESC cis rs9527 0.615 rs7899622 chr10:104727333 C/T cg04362960 chr10:104952993 NT5C2 0.43 5.34 0.31 1.97e-7 Arsenic metabolism; CESC cis rs9300255 0.602 rs10846486 chr12:123709927 G/A cg19016782 chr12:123741754 C12orf65 -0.45 -6.55 -0.37 2.97e-10 Neutrophil percentage of white cells; CESC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.18 0.3 4.42e-7 Bipolar disorder; CESC cis rs10870270 1.000 rs10159943 chr10:133744744 T/C cg17892150 chr10:133769511 PPP2R2D -0.86 -12.61 -0.61 6.93e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs9916302 0.652 rs9903269 chr17:37742383 A/T cg00129232 chr17:37814104 STARD3 -0.55 -5.22 -0.31 3.64e-7 Glomerular filtration rate (creatinine); CESC cis rs2066819 0.892 rs2066807 chr12:56740682 C/G cg26734620 chr12:56694298 CS 0.98 5.95 0.34 8.45e-9 Psoriasis vulgaris; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19452060 chr12:57914632 DDIT3 -0.47 -6.27 -0.36 1.48e-9 Ulcerative colitis; CESC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.87e-17 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27382058 chr22:43506933 BIK 0.54 6.98 0.39 2.39e-11 Gut microbiome composition (summer); CESC cis rs7786877 0.626 rs11767547 chr7:100221635 C/T cg20848291 chr7:100343083 ZAN -0.67 -6.94 -0.39 2.94e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9549260 0.564 rs4941990 chr13:41299857 A/C cg21288729 chr13:41239152 FOXO1 0.59 7.63 0.42 4.25e-13 Red blood cell count; CESC trans rs11098499 0.954 rs59394118 chr4:120295551 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.23 0.49 8.9e-18 Corneal astigmatism; CESC cis rs6582630 0.560 rs4882325 chr12:38510037 C/T cg26384229 chr12:38710491 ALG10B -0.45 -5.99 -0.35 6.96e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7562790 0.535 rs28705335 chr2:36655721 T/C cg09467607 chr2:36825704 FEZ2 0.33 5.2 0.3 3.98e-7 QRS duration;QRS complex (Cornell); CESC cis rs921665 0.584 rs5019161 chr2:3174761 A/G cg02624386 chr2:3182749 NA 0.5 5.13 0.3 5.69e-7 World class endurance athleticism; CESC cis rs4268898 0.662 rs74470633 chr2:24438712 A/G cg06627628 chr2:24431161 ITSN2 -1.02 -11.2 -0.57 4.2e-24 Asthma; CESC cis rs7208859 0.623 rs11652533 chr17:29060601 A/C cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg22920501 chr2:26401640 FAM59B 0.94 11.01 0.56 1.85e-23 Gut microbiome composition (summer); CESC cis rs7918232 0.941 rs4749230 chr10:27441218 C/T cg14442939 chr10:27389572 ANKRD26 0.67 6.72 0.38 1.09e-10 Breast cancer; CESC cis rs28374715 0.532 rs28897479 chr15:41690851 T/G cg18705301 chr15:41695430 NDUFAF1 -1.08 -16.89 -0.72 6.07e-44 Ulcerative colitis; CESC cis rs561341 0.941 rs2428338 chr17:30299629 T/C cg12193833 chr17:30244370 NA -0.58 -5.85 -0.34 1.41e-8 Hip circumference adjusted for BMI; CESC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.72 -10.4 -0.54 1.76e-21 Prudent dietary pattern; CESC cis rs4243830 0.737 rs6692747 chr1:6610049 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.76 5.87 0.34 1.29e-8 Body mass index; CESC cis rs1559088 0.947 rs7256182 chr19:33558591 G/A cg27124370 chr19:33622961 WDR88 0.43 5.41 0.32 1.41e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6893300 0.857 rs6860716 chr5:179162840 T/C cg14593053 chr5:179126677 CANX -0.45 -5.03 -0.3 9.11e-7 Resting heart rate; CESC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg15112475 chr7:1198522 ZFAND2A -0.38 -5.93 -0.34 9.19e-9 Longevity;Endometriosis; CESC cis rs6429082 0.521 rs704711 chr1:235629802 G/A cg26050004 chr1:235667680 B3GALNT2 0.82 12.83 0.62 1.26e-29 Adiposity; CESC cis rs4268898 0.552 rs12620938 chr2:24367122 C/A cg20701182 chr2:24300061 SF3B14 -0.39 -5.47 -0.32 1.03e-7 Asthma; CESC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg27170947 chr2:26402098 FAM59B -0.85 -9.9 -0.52 7.08e-20 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20756454 chr17:28951397 LRRC37B2 -0.6 -6.3 -0.36 1.23e-9 Gut microbiome composition (summer); CESC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg26343298 chr8:95960752 TP53INP1 0.37 6.22 0.36 1.96e-9 Type 2 diabetes; CESC cis rs7833986 0.534 rs17813240 chr8:56925791 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.6 7.3 0.41 3.36e-12 Height; CESC cis rs992157 1.000 rs13429408 chr2:219142860 C/A cg20019365 chr2:219134978 PNKD;AAMP 0.75 10.39 0.54 1.89e-21 Colorectal cancer; CESC cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg24308560 chr3:49941425 MST1R 0.55 7.82 0.43 1.28e-13 Body mass index; CESC cis rs5750830 0.594 rs9611166 chr22:39775268 T/C cg01416388 chr22:39784598 NA -0.54 -7.15 -0.4 8.7e-12 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14461963 chr10:12111049 DHTKD1 0.51 6.53 0.37 3.34e-10 Gut microbiota (bacterial taxa); CESC cis rs1953600 0.521 rs7067644 chr10:81924245 A/G cg00277334 chr10:82204260 NA -0.49 -6.76 -0.38 8.9e-11 Sarcoidosis; CESC cis rs11030122 0.702 rs10835403 chr11:3990941 A/C cg18678763 chr11:4115507 RRM1 0.43 5.03 0.3 8.95e-7 Mean platelet volume;Platelet distribution width; CESC cis rs9527 0.640 rs6584541 chr10:104929124 A/G cg04362960 chr10:104952993 NT5C2 0.42 5.26 0.31 3.03e-7 Arsenic metabolism; CESC cis rs9911578 0.740 rs368243 chr17:56708979 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.41 5.31 0.31 2.34e-7 Intelligence (multi-trait analysis); CESC cis rs8028182 0.636 rs11637586 chr15:75791112 G/C cg20655648 chr15:75932815 IMP3 0.47 5.87 0.34 1.33e-8 Sudden cardiac arrest; CESC cis rs1395 0.778 rs17005956 chr2:27451099 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 5.49 0.32 9.35e-8 Blood metabolite levels; CESC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg22800045 chr5:56110881 MAP3K1 -0.6 -7.71 -0.43 2.55e-13 Initial pursuit acceleration; CESC cis rs9837602 1.000 rs7616988 chr3:99701134 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -6.78 -0.38 7.72e-11 Breast cancer; CESC trans rs57221529 0.713 rs12522724 chr5:590742 T/C cg25482853 chr8:67687455 SGK3 1.0 10.02 0.52 2.99e-20 Lung disease severity in cystic fibrosis; CESC cis rs870825 0.581 rs7675106 chr4:185652388 C/G cg04058563 chr4:185651563 MLF1IP -0.6 -6.93 -0.39 3.28e-11 Blood protein levels; CESC cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg25019033 chr10:957182 NA -0.56 -5.92 -0.34 9.7e-9 Eosinophil percentage of granulocytes; CESC cis rs17253792 0.545 rs34136598 chr14:56013238 C/T cg01858014 chr14:56050164 KTN1 -0.79 -5.58 -0.32 5.93e-8 Putamen volume; CESC trans rs561341 1.000 rs72823789 chr17:30284084 G/A cg27661571 chr11:113659931 NA -0.87 -8.06 -0.44 2.57e-14 Hip circumference adjusted for BMI; CESC cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg12193833 chr17:30244370 NA -0.49 -5.21 -0.3 3.78e-7 Hip circumference adjusted for BMI; CESC cis rs4604732 0.588 rs74154678 chr1:247626202 A/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg11644478 chr21:40555479 PSMG1 -0.55 -7.55 -0.42 7.19e-13 Menarche (age at onset); CESC cis rs7714584 1.000 rs10065172 chr5:150227998 C/T cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.64e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6460942 1.000 rs112996286 chr7:12315741 G/C cg02935154 chr7:12443704 VWDE -0.59 -5.84 -0.34 1.5e-8 Coronary artery disease; CESC cis rs9611565 0.569 rs188057 chr22:41822305 T/G cg06634786 chr22:41940651 POLR3H 0.71 7.17 0.4 7.6e-12 Vitiligo; CESC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.754 rs10213554 chr4:120260785 A/G cg09307838 chr4:120376055 NA -0.78 -10.45 -0.54 1.28e-21 Corneal astigmatism; CESC cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.8 8.16 0.45 1.33e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4835473 0.897 rs13145976 chr4:144656863 T/A cg25736465 chr4:144833511 NA -0.36 -5.54 -0.32 7.38e-8 Immature fraction of reticulocytes; CESC cis rs7089973 0.604 rs7895830 chr10:116625776 A/G cg25233709 chr10:116636983 FAM160B1 0.4 6.61 0.38 2.08e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7312774 0.618 rs4964500 chr12:107320788 T/C cg16260113 chr12:107380972 MTERFD3 0.79 6.85 0.39 5.21e-11 Severe influenza A (H1N1) infection; CESC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.35e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6496667 1.000 rs8042825 chr15:90897885 C/G cg22089800 chr15:90895588 ZNF774 -0.55 -5.61 -0.33 5.11e-8 Rheumatoid arthritis; CESC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg23758822 chr17:41437982 NA 1.05 15.68 0.69 1.15e-39 Menopause (age at onset); CESC cis rs9291683 0.692 rs1558489 chr4:10325489 T/A cg00071950 chr4:10020882 SLC2A9 -0.52 -7.72 -0.43 2.32e-13 Bone mineral density; CESC cis rs2213920 0.516 rs2188042 chr9:118159740 C/T cg13918206 chr9:118159781 DEC1 -0.7 -5.54 -0.32 7.42e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00490421 chr12:69326528 CPM -0.53 -6.14 -0.35 2.93e-9 Gut microbiome composition (summer); CESC cis rs8067545 0.611 rs2703795 chr17:20077141 C/A cg13482628 chr17:19912719 NA -0.43 -5.75 -0.33 2.45e-8 Schizophrenia; CESC cis rs17655565 1.000 rs17655565 chr12:52691958 T/C cg08257133 chr12:52711352 KRT83 0.45 5.09 0.3 6.86e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18827097 chr2:3522506 ADI1 0.49 6.37 0.36 8.28e-10 Gut microbiota (bacterial taxa); CESC cis rs30380 0.586 rs28119 chr5:96131733 G/A cg16492584 chr5:96139282 ERAP1 -0.49 -6.65 -0.38 1.7e-10 Cerebrospinal fluid biomarker levels; CESC cis rs2070997 0.667 rs72765063 chr9:133717391 G/A cg11464064 chr9:133710261 ABL1 0.69 7.38 0.41 2.11e-12 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04334422 chr4:8398880 ACOX3 -0.61 -6.65 -0.38 1.68e-10 Gut microbiome composition (summer); CESC cis rs863345 0.604 rs11265007 chr1:158498522 C/T cg12129480 chr1:158549410 OR10X1 0.33 6.54 0.37 3.11e-10 Pneumococcal bacteremia; CESC cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg20701182 chr2:24300061 SF3B14 -0.91 -10.15 -0.53 1.13e-20 Lymphocyte counts; CESC cis rs4919087 0.810 rs10736115 chr10:99031685 A/G cg25902810 chr10:99078978 FRAT1 0.67 9.43 0.5 2.24e-18 Monocyte count; CESC cis rs3820928 0.874 rs6717168 chr2:227901342 C/T cg05526886 chr2:227700861 RHBDD1 -0.43 -5.53 -0.32 7.56e-8 Pulmonary function; CESC cis rs9915657 0.773 rs9894696 chr17:70099487 C/T cg06234051 chr17:70120541 SOX9 -0.33 -5.1 -0.3 6.48e-7 Thyroid hormone levels; CESC cis rs6987853 0.563 rs10958723 chr8:42448188 T/C cg09913449 chr8:42400586 C8orf40 0.33 5.25 0.31 3.17e-7 Mean corpuscular hemoglobin concentration; CESC cis rs35110281 0.548 rs2838350 chr21:45109972 T/C cg04455712 chr21:45112962 RRP1B 0.5 7.72 0.43 2.45e-13 Mean corpuscular volume; CESC cis rs116095464 1.000 rs1567956 chr5:315616 C/A cg22857025 chr5:266934 NA -1.21 -10.53 -0.54 7.01e-22 Breast cancer; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg25355226 chr3:150320980 SELT -0.53 -6.98 -0.39 2.34e-11 Height; CESC cis rs7089973 0.604 rs17095662 chr10:116596071 A/C cg03647239 chr10:116582469 FAM160B1 0.41 5.08 0.3 7.3e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs3087591 1.000 rs2854331 chr17:29711728 G/A cg24425628 chr17:29625626 OMG;NF1 -0.43 -5.21 -0.31 3.71e-7 Hip circumference; CESC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg18016565 chr1:150552671 MCL1 0.33 5.15 0.3 5.13e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18126572 chr7:43909213 MRPS24 0.58 6.57 0.37 2.72e-10 Gut microbiome composition (summer); CESC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -6.7 -0.38 1.27e-10 Total body bone mineral density; CESC cis rs28647808 1.000 rs28729896 chr9:136277796 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.88 5.66 0.33 3.88e-8 Blood protein levels; CESC cis rs7216064 1.000 rs9912084 chr17:65868035 A/C cg12091567 chr17:66097778 LOC651250 -0.8 -9.03 -0.49 3.62e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07483432 chr12:72079704 TMEM19 -0.47 -6.5 -0.37 4.08e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg04478727 chr12:58166393 METTL1;FAM119B 0.73 9.34 0.5 4.23e-18 Multiple sclerosis; CESC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.84e-7 Gut microbiome composition (summer); CESC cis rs2455799 0.574 rs2455800 chr3:15701589 T/G cg16303742 chr3:15540471 COLQ -0.38 -6.13 -0.35 3.19e-9 Mean platelet volume; CESC cis rs34779708 0.931 rs67976880 chr10:35372261 G/C cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 13.51 0.64 5.48e-32 Platelet count; CESC cis rs864537 0.646 rs2995091 chr1:167434277 T/C cg22356347 chr1:167427500 CD247 -0.4 -8.17 -0.45 1.31e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs2404602 0.692 rs35170561 chr15:77130695 C/T cg22467129 chr15:76604101 ETFA -0.34 -5.07 -0.3 7.56e-7 Blood metabolite levels; CESC cis rs1788820 0.917 rs1652349 chr18:21142734 A/T cg14672496 chr18:21087552 C18orf8 0.55 7.43 0.42 1.5e-12 Body mass index; CESC trans rs12681287 0.547 rs7459877 chr8:87505660 G/A cg27317242 chr8:23145699 R3HCC1 -0.53 -6.35 -0.36 9.05e-10 Caudate activity during reward; CESC trans rs9447700 1.000 rs2872785 chr6:77141238 A/G cg17508591 chr5:140214138 PCDHA6;PCDHA2;PCDHA1;PCDHA7;PCDHA5;PCDHA3;PCDHA4 -0.37 -6.02 -0.35 5.87e-9 Menarche (age at onset); CESC cis rs17376456 0.877 rs10476597 chr5:93367172 C/T cg21475434 chr5:93447410 FAM172A -0.85 -7.34 -0.41 2.7e-12 Diabetic retinopathy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06070291 chr15:44828899 EIF3J -0.47 -6.34 -0.36 9.58e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9479482 0.935 rs9479507 chr6:150366514 T/G cg03788504 chr6:150331562 NA -0.34 -6.36 -0.36 8.57e-10 Alopecia areata; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24088293 chr10:13141924 OPTN -0.4 -6.37 -0.36 8.46e-10 Gambling; CESC cis rs10871290 0.650 rs28484753 chr16:74489395 G/C cg01733217 chr16:74700730 RFWD3 0.75 9.85 0.52 1.08e-19 Breast cancer; CESC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg05564831 chr3:52568323 NT5DC2 0.45 6.39 0.37 7.51e-10 Bipolar disorder; CESC cis rs9837602 1.000 rs1038294 chr3:99503728 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.52 -7.18 -0.4 7.08e-12 Breast cancer; CESC cis rs1801251 1.000 rs6761324 chr2:233582793 T/G cg08000102 chr2:233561755 GIGYF2 0.69 9.31 0.5 4.9e-18 Coronary artery disease; CESC cis rs2688608 0.617 rs6480709 chr10:75479125 T/C cg23231163 chr10:75533350 FUT11 -0.37 -5.67 -0.33 3.78e-8 Inflammatory bowel disease; CESC cis rs12142240 0.698 rs17361915 chr1:46847321 C/T cg00530320 chr1:46809349 NSUN4 0.6 8.3 0.45 5.19e-15 Menopause (age at onset); CESC cis rs372883 0.600 rs1153277 chr21:30666867 A/T cg08807101 chr21:30365312 RNF160 -0.48 -5.71 -0.33 2.96e-8 Pancreatic cancer; CESC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg04166393 chr7:2884313 GNA12 0.6 7.7 0.43 2.66e-13 Height; CESC cis rs2243480 1.000 rs906134 chr7:65444288 G/C cg12463550 chr7:65579703 CRCP 0.69 5.5 0.32 9.16e-8 Diabetic kidney disease; CESC cis rs1005224 0.853 rs12898082 chr14:76306359 A/C cg25116370 chr14:76127843 TTLL5;C14orf1 0.41 5.44 0.32 1.21e-7 Large artery stroke; CESC cis rs3820928 0.709 rs2894627 chr2:227910171 A/G cg11843606 chr2:227700838 RHBDD1 -0.45 -5.47 -0.32 1.03e-7 Pulmonary function; CESC cis rs950169 0.922 rs11633075 chr15:85113972 C/A cg17507749 chr15:85114479 UBE2QP1 0.54 6.11 0.35 3.61e-9 Schizophrenia; CESC cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg04450456 chr4:17643702 FAM184B 0.38 5.35 0.31 1.95e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9831754 0.704 rs9836909 chr3:78451594 A/G cg06138941 chr3:78371609 NA -0.49 -6.07 -0.35 4.35e-9 Calcium levels; CESC cis rs9911578 0.935 rs12948039 chr17:57045184 C/T cg12560992 chr17:57184187 TRIM37 0.82 12.96 0.62 4.31e-30 Intelligence (multi-trait analysis); CESC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg27266027 chr21:40555129 PSMG1 0.45 5.34 0.31 2.05e-7 Cognitive function; CESC cis rs6456156 0.586 rs6909180 chr6:167460537 A/G cg07741184 chr6:167504864 NA 0.35 6.0 0.35 6.57e-9 Primary biliary cholangitis; CESC cis rs6424115 1.000 rs12031592 chr1:24127864 A/C cg15997130 chr1:24165203 NA 0.44 6.15 0.35 2.78e-9 Immature fraction of reticulocytes; CESC cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg20476274 chr7:133979776 SLC35B4 0.68 9.88 0.52 8.59e-20 Mean platelet volume; CESC trans rs11098499 0.754 rs7689729 chr4:120256192 A/G cg25214090 chr10:38739885 LOC399744 0.64 9.04 0.49 3.46e-17 Corneal astigmatism; CESC cis rs703842 0.575 rs701006 chr12:58106836 C/T cg18357645 chr12:58087776 OS9 -0.56 -9.31 -0.5 5.06e-18 Multiple sclerosis; CESC cis rs34779708 0.931 rs12248333 chr10:35362977 A/G cg04310649 chr10:35416472 CREM -0.54 -6.39 -0.37 7.6e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg13866156 chr1:1669148 SLC35E2 -0.5 -6.53 -0.37 3.26e-10 Body mass index; CESC cis rs9796 0.576 rs13329511 chr15:41299121 T/C cg02330683 chr15:41787940 ITPKA 0.37 5.05 0.3 8.14e-7 Menopause (age at onset); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg20873039 chr2:180871638 CWC22 -0.51 -7.35 -0.41 2.53e-12 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6912958 0.525 rs586771 chr6:88064971 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.47 8.42 0.46 2.42e-15 Monocyte percentage of white cells; CESC cis rs7727544 0.709 rs441969 chr5:131702120 G/A cg07395648 chr5:131743802 NA -0.42 -5.33 -0.31 2.09e-7 Blood metabolite levels; CESC cis rs616402 0.527 rs589151 chr1:10567711 C/T cg07384165 chr1:10488281 NA -0.58 -8.63 -0.47 5.96e-16 Breast size; CESC cis rs727505 0.954 rs67146030 chr7:124561790 T/G cg23710748 chr7:124431027 NA -0.48 -7.43 -0.42 1.48e-12 Lewy body disease; CESC cis rs832540 0.931 rs832399 chr5:56222358 A/T cg24531977 chr5:56204891 C5orf35 -0.43 -5.45 -0.32 1.15e-7 Coronary artery disease; CESC cis rs7772486 0.875 rs863820 chr6:146347402 C/T cg05347473 chr6:146136440 FBXO30 -0.5 -6.6 -0.38 2.28e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg10691866 chr7:65817282 TPST1 -0.33 -5.39 -0.31 1.58e-7 Aortic root size; CESC trans rs561341 0.883 rs1034626 chr17:30219500 C/G cg27661571 chr11:113659931 NA 0.62 6.52 0.37 3.64e-10 Hip circumference adjusted for BMI; CESC cis rs9486719 1.000 rs926276 chr6:96868735 C/T cg06623918 chr6:96969491 KIAA0776 0.89 10.0 0.52 3.56e-20 Migraine;Coronary artery disease; CESC cis rs7520050 0.966 rs4660319 chr1:46341623 C/T cg24296786 chr1:45957014 TESK2 0.42 5.37 0.31 1.69e-7 Red blood cell count;Reticulocyte count; CESC cis rs4692589 0.965 rs2291167 chr4:170950887 G/A cg19918862 chr4:170955249 NA 0.38 6.04 0.35 5.16e-9 Anxiety disorder; CESC cis rs6783573 0.683 rs3806702 chr3:46617502 T/C cg21489266 chr3:46619131 LRRC2;TDGF1 -0.54 -7.79 -0.43 1.48e-13 Cerebrospinal fluid biomarker levels; CESC cis rs7474896 0.559 rs1208560 chr10:38221618 A/T cg25427524 chr10:38739819 LOC399744 0.48 5.49 0.32 9.28e-8 Obesity (extreme); CESC cis rs3749237 0.595 rs4855839 chr3:49507847 G/A cg02487422 chr3:49467188 NICN1 0.58 8.37 0.46 3.39e-15 Resting heart rate; CESC cis rs6546550 0.900 rs897122 chr2:70140271 C/T cg02498382 chr2:70120550 SNRNP27 -0.4 -7.03 -0.4 1.71e-11 Prevalent atrial fibrillation; CESC cis rs12477438 0.765 rs7591794 chr2:99567514 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.87 -0.48 1.09e-16 Chronic sinus infection; CESC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -7.09 -0.4 1.22e-11 Extrinsic epigenetic age acceleration; CESC cis rs2204008 0.837 rs11180821 chr12:38242843 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.52 0.32 7.92e-8 Bladder cancer; CESC cis rs17376456 0.825 rs13165400 chr5:93091427 G/A cg21475434 chr5:93447410 FAM172A 0.83 7.31 0.41 3.16e-12 Diabetic retinopathy; CESC cis rs9948 0.655 rs17119562 chr2:97381844 G/C cg01990225 chr2:97406019 LMAN2L -0.99 -7.31 -0.41 3.23e-12 Erectile dysfunction and prostate cancer treatment; CESC trans rs853679 0.546 rs35353359 chr6:28324378 C/T cg01620082 chr3:125678407 NA -0.83 -6.55 -0.37 2.93e-10 Depression; CESC cis rs4523957 0.614 rs2641439 chr17:2017561 C/G cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs5758659 0.652 rs133349 chr22:42428727 A/T cg05082376 chr22:42548792 NA -0.38 -5.59 -0.32 5.52e-8 Cognitive function; CESC cis rs2404602 0.716 rs7169394 chr15:76913274 G/A cg22467129 chr15:76604101 ETFA -0.36 -5.31 -0.31 2.34e-7 Blood metabolite levels; CESC cis rs7165102 1.000 rs6494521 chr15:65739928 A/T cg11441148 chr15:65824328 PTPLAD1 0.31 5.18 0.3 4.29e-7 Mean corpuscular hemoglobin; CESC cis rs8114671 0.562 rs6087643 chr20:33474462 C/T cg06115741 chr20:33292138 TP53INP2 0.48 5.8 0.34 1.91e-8 Height; CESC cis rs763121 0.853 rs138702 chr22:39132601 A/T cg21395723 chr22:39101663 GTPBP1 -0.48 -6.37 -0.36 8.53e-10 Menopause (age at onset); CESC cis rs9314323 0.964 rs3808579 chr8:26250682 C/T cg13160058 chr8:26243215 BNIP3L -0.32 -5.14 -0.3 5.26e-7 Red cell distribution width; CESC cis rs11696501 0.637 rs6104298 chr20:44327774 A/G cg11783356 chr20:44313418 WFDC10B -0.31 -5.08 -0.3 7.02e-7 Brain structure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27003951 chr16:11350045 SOCS1 0.6 6.95 0.39 2.8e-11 Gut microbiome composition (summer); CESC cis rs11608355 0.515 rs4766605 chr12:109895636 C/A cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs3087591 1.000 rs8068801 chr17:29570587 G/T cg24425628 chr17:29625626 OMG;NF1 -0.45 -5.63 -0.33 4.56e-8 Hip circumference; CESC cis rs72781680 1.000 rs12620594 chr2:24194490 G/A cg08917208 chr2:24149416 ATAD2B 0.94 8.54 0.46 1.09e-15 Lymphocyte counts; CESC cis rs1915146 0.546 rs2454055 chr10:126859832 T/C cg17191109 chr10:126851326 NA 0.42 6.68 0.38 1.36e-10 Menarche (age at onset); CESC cis rs8005677 1.000 rs7155857 chr14:23400059 C/A cg01529538 chr14:23388837 RBM23 0.5 6.72 0.38 1.14e-10 Cognitive ability (multi-trait analysis); CESC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg06481639 chr22:41940642 POLR3H 0.6 5.9 0.34 1.13e-8 Vitiligo; CESC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.42 -5.48 -0.32 9.81e-8 Total body bone mineral density; CESC cis rs12291225 0.679 rs1043237 chr11:14289053 A/T cg19336497 chr11:14380999 RRAS2 -0.36 -5.31 -0.31 2.27e-7 Sense of smell; CESC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg00149659 chr3:10157352 C3orf10 0.74 8.69 0.47 3.76e-16 Alzheimer's disease; CESC trans rs7819412 0.654 rs34741518 chr8:10776860 A/C cg06636001 chr8:8085503 FLJ10661 -0.58 -7.43 -0.42 1.54e-12 Triglycerides; CESC cis rs12500824 0.564 rs72657826 chr4:77293574 G/A cg20311846 chr4:77356250 SHROOM3 0.37 6.68 0.38 1.41e-10 Coronary artery disease; CESC cis rs11098499 0.954 rs71614438 chr4:120371252 G/A cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs9436747 0.626 rs7516763 chr1:65972550 C/A cg14976592 chr1:65886160 LEPROT;LEPR -0.43 -5.23 -0.31 3.38e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC cis rs7520050 0.966 rs12144263 chr1:46352446 G/A cg03146154 chr1:46216737 IPP -0.48 -6.22 -0.36 1.94e-9 Red blood cell count;Reticulocyte count; CESC cis rs79976124 0.800 rs6918860 chr6:66637741 G/C cg07460842 chr6:66804631 NA 0.69 8.03 0.44 3.13e-14 Type 2 diabetes; CESC cis rs9921222 0.500 rs8046256 chr16:393948 C/T cg08923669 chr16:420230 MRPL28 -0.5 -5.54 -0.32 7.37e-8 Bone mineral density (spine);Bone mineral density; CESC cis rs7267979 0.903 rs2474766 chr20:25246153 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.62 0.69 2.01e-39 Liver enzyme levels (alkaline phosphatase); CESC cis rs9915657 0.933 rs8075603 chr17:70136833 G/T cg09344028 chr17:70110421 NA 0.32 5.93 0.34 9.32e-9 Thyroid hormone levels; CESC cis rs79349575 0.783 rs11079844 chr17:47028334 G/A cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs7772486 0.875 rs1331637 chr6:146337087 T/C cg05347473 chr6:146136440 FBXO30 0.52 6.71 0.38 1.17e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg24642844 chr7:1081250 C7orf50 -0.38 -5.05 -0.3 8.17e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20375947 chr15:25454579 SNORD115-15;SNORD115-21;SNORD115-22 0.34 6.2 0.36 2.21e-9 Fibrinogen levels; CESC cis rs10883723 0.810 rs10748824 chr10:104274466 T/C cg22532475 chr10:104410764 TRIM8 -0.33 -5.68 -0.33 3.5e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs72945132 0.882 rs11235739 chr11:70132780 C/T cg00319359 chr11:70116639 PPFIA1 0.76 7.74 0.43 2.05e-13 Coronary artery disease; CESC cis rs7833986 0.501 rs2976044 chr8:56986737 A/G cg26371346 chr8:56986568 SNORD54;RPS20 0.61 6.0 0.35 6.52e-9 Height; CESC cis rs9487051 0.676 rs6568568 chr6:109597048 C/T cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC cis rs344364 0.511 rs1742395 chr16:1955965 G/A cg26617929 chr16:1858877 NA -0.52 -5.45 -0.32 1.13e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs2880765 0.835 rs900573 chr15:86037993 G/T cg10818794 chr15:86012489 AKAP13 0.34 5.29 0.31 2.61e-7 Coronary artery disease; CESC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg03264133 chr6:25882463 NA -0.47 -6.47 -0.37 4.71e-10 Intelligence (multi-trait analysis); CESC cis rs72720396 0.789 rs12048450 chr1:91199660 G/A cg13456504 chr1:91191583 NA 0.49 7.07 0.4 1.38e-11 Morning vs. evening chronotype;Chronotype; CESC cis rs9393777 0.588 rs9467772 chr6:26496578 A/T cg12826209 chr6:26865740 GUSBL1 0.59 6.84 0.39 5.36e-11 Intelligence (multi-trait analysis); CESC cis rs73206853 0.698 rs1018133 chr12:111121302 G/C cg12870014 chr12:110450643 ANKRD13A 0.68 5.79 0.33 2.02e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9911578 1.000 rs302840 chr17:56673079 C/G cg05425664 chr17:57184151 TRIM37 -0.49 -6.83 -0.39 5.7e-11 Intelligence (multi-trait analysis); CESC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg21782813 chr7:2030301 MAD1L1 0.52 7.43 0.42 1.49e-12 Bipolar disorder and schizophrenia; CESC cis rs977987 0.806 rs4888416 chr16:75449176 C/G cg03315344 chr16:75512273 CHST6 0.41 5.81 0.34 1.79e-8 Dupuytren's disease; CESC cis rs190217029 1 rs190217029 chr11:111092986 C/G cg08450021 chr11:111101517 NA -0.42 -5.22 -0.31 3.57e-7 Carotid plaque burden; CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg18404041 chr3:52824283 ITIH1 -0.37 -6.59 -0.38 2.32e-10 Electroencephalogram traits; CESC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg13114125 chr14:105738426 BRF1 -0.89 -10.86 -0.55 5.82e-23 Mean platelet volume;Platelet distribution width; CESC cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg05585544 chr11:47624801 NA -0.47 -6.94 -0.39 3e-11 Subjective well-being; CESC cis rs916888 0.773 rs538628 chr17:44787313 G/C cg17911788 chr17:44343683 NA -0.62 -8.15 -0.45 1.43e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6500602 0.701 rs4785968 chr16:4535307 T/A cg08645402 chr16:4508243 NA 0.42 6.49 0.37 4.13e-10 Schizophrenia; CESC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg18305652 chr10:134549665 INPP5A 0.49 7.11 0.4 1.1e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg21918786 chr6:109611834 NA -0.4 -6.1 -0.35 3.81e-9 Reticulocyte fraction of red cells; CESC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg25072359 chr17:41440525 NA 0.48 7.35 0.41 2.44e-12 Menopause (age at onset); CESC cis rs6088813 0.857 rs6142378 chr20:33997291 T/A cg14752227 chr20:34000481 UQCC -0.4 -5.08 -0.3 7.17e-7 Height; CESC cis rs1620921 0.505 rs13199812 chr6:161201960 T/C cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC trans rs7089973 0.523 rs61869297 chr10:116779005 G/C cg17463145 chr7:79084011 MAGI2 0.3 6.06 0.35 4.75e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7020830 0.823 rs13285624 chr9:37129496 T/G cg14294708 chr9:37120828 ZCCHC7 1.25 24.2 0.83 4.65e-69 Schizophrenia; CESC cis rs8072100 0.701 rs4794053 chr17:45769551 G/A cg08085267 chr17:45401833 C17orf57 -0.43 -5.43 -0.32 1.27e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg06420487 chr17:61919686 SMARCD2 0.45 5.42 0.32 1.33e-7 Height; CESC cis rs2075371 0.932 rs11766132 chr7:133993062 T/C cg11752832 chr7:134001865 SLC35B4 0.53 6.89 0.39 3.97e-11 Mean platelet volume; CESC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6831352 0.918 rs13143133 chr4:100054970 A/G cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs911555 0.755 rs6575988 chr14:103900827 G/T cg09975044 chr14:104007538 NA -0.41 -5.22 -0.31 3.71e-7 Intelligence (multi-trait analysis); CESC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg22535103 chr8:58192502 C8orf71 -0.74 -8.78 -0.47 2.09e-16 Developmental language disorder (linguistic errors); CESC cis rs6546537 1.000 rs2048256 chr2:69847357 G/C cg10773587 chr2:69614142 GFPT1 -0.52 -6.41 -0.37 6.57e-10 Serum thyroid-stimulating hormone levels; CESC cis rs11122272 0.735 rs2244994 chr1:231537127 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.73 -0.43 2.29e-13 Hemoglobin concentration; CESC cis rs9910055 0.530 rs7222349 chr17:42304644 C/T cg08499158 chr17:42289980 UBTF -0.41 -5.24 -0.31 3.34e-7 Total body bone mineral density; CESC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.97 0.8 1.29e-61 Prudent dietary pattern; CESC cis rs17253792 0.822 rs76267907 chr14:56066969 C/A cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC cis rs797680 0.586 rs2281525 chr1:93595306 G/C cg15093775 chr1:93646470 TMED5;CCDC18 -0.38 -5.79 -0.34 1.97e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts; CESC cis rs1707322 0.721 rs28442079 chr1:46172001 A/G cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs722599 0.748 rs59112602 chr14:75358817 C/G cg00095594 chr1:236228625 NID1 -0.4 -6.11 -0.35 3.53e-9 IgG glycosylation; CESC cis rs6582630 0.555 rs12372536 chr12:38400864 C/G cg26384229 chr12:38710491 ALG10B 0.72 10.94 0.56 3.12e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs34638657 0.732 rs62045964 chr16:82200920 T/C cg09439754 chr16:82129088 HSD17B2 -0.36 -6.24 -0.36 1.71e-9 Lung adenocarcinoma; CESC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg12463550 chr7:65579703 CRCP 0.51 6.41 0.37 6.58e-10 Aortic root size; CESC cis rs921968 0.565 rs6436082 chr2:219639430 A/G cg02176678 chr2:219576539 TTLL4 -0.44 -7.74 -0.43 2.15e-13 Mean corpuscular hemoglobin concentration; CESC cis rs4654899 0.865 rs6658526 chr1:21391314 A/G cg05370193 chr1:21551575 ECE1 -0.42 -6.19 -0.36 2.25e-9 Superior frontal gyrus grey matter volume; CESC cis rs933688 0.938 rs12110065 chr5:90718474 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.97 12.5 0.61 1.77e-28 Smoking behavior; CESC cis rs7542091 0.669 rs11119357 chr1:210042382 C/T cg23283495 chr1:209979779 IRF6 0.33 5.25 0.31 3.06e-7 Monobrow; CESC cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg26597838 chr10:835615 NA 0.72 8.01 0.44 3.58e-14 Eosinophil percentage of granulocytes; CESC cis rs2455799 0.613 rs3924773 chr3:15796853 G/A cg16303742 chr3:15540471 COLQ -0.39 -6.14 -0.35 3.01e-9 Mean platelet volume; CESC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.71 0.38 1.17e-10 Intelligence (multi-trait analysis); CESC cis rs10242455 0.702 rs57832867 chr7:98966396 C/T cg18809830 chr7:99032528 PTCD1 -0.7 -5.07 -0.3 7.34e-7 Blood metabolite levels; CESC cis rs11792861 0.926 rs75128146 chr9:111833791 G/T cg13535736 chr9:111863775 C9orf5 -0.52 -6.9 -0.39 3.71e-11 Menarche (age at onset); CESC cis rs559928 0.606 rs7941773 chr11:63952759 C/T cg18225595 chr11:63971243 STIP1 0.69 6.2 0.36 2.17e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs73019876 0.901 rs1848998 chr19:22135280 A/G cg11619707 chr19:22235551 ZNF257 -0.27 -5.12 -0.3 5.8e-7 Testicular germ cell tumor; CESC trans rs4950322 0.580 rs17355474 chr1:146592123 C/T cg04954894 chr8:38089920 DDHD2 -0.59 -6.39 -0.37 7.54e-10 Protein quantitative trait loci; CESC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC trans rs9929218 1.000 rs7200690 chr16:68778457 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -9.71 -0.51 2.91e-19 Colorectal cancer; CESC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.94 8.93 0.48 7.5e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2479106 0.889 rs7026674 chr9:126452936 C/T cg16191174 chr9:126692580 DENND1A 0.47 6.17 0.35 2.5e-9 Polycystic ovary syndrome; CESC cis rs11122272 0.735 rs2808584 chr1:231512925 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg18876405 chr7:65276391 NA -0.56 -6.11 -0.35 3.54e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15133313 chr6:53213956 ELOVL5 0.51 6.11 0.35 3.56e-9 Gut microbiome composition (summer); CESC cis rs459571 1.000 rs2810489 chr9:136922700 C/T cg13789015 chr9:136890014 NCRNA00094 0.55 7.79 0.43 1.53e-13 Platelet distribution width; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19542841 chr11:64073530 ESRRA -0.46 -6.42 -0.37 6.38e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs826838 0.754 rs2387920 chr12:38626351 A/G cg26384229 chr12:38710491 ALG10B 0.74 11.21 0.57 3.91e-24 Heart rate; CESC cis rs9815354 1.000 rs6768128 chr3:41865080 G/A cg03022575 chr3:42003672 ULK4 0.47 5.24 0.31 3.33e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs13253111 0.603 rs17058753 chr8:28090914 T/C cg26534493 chr8:28060551 NA 0.52 8.02 0.44 3.36e-14 Childhood body mass index; CESC cis rs11122272 0.766 rs2024879 chr1:231528638 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg11764359 chr7:65958608 NA 0.94 14.51 0.67 1.69e-35 Aortic root size; CESC cis rs1775715 0.870 rs7912121 chr10:32228995 T/G cg18675610 chr10:32216311 ARHGAP12 0.37 5.53 0.32 7.74e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1018836 0.884 rs7823461 chr8:91581075 T/C cg16814680 chr8:91681699 NA -0.72 -10.29 -0.53 4.15e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9291683 0.575 rs3756223 chr4:10105797 C/T cg11266682 chr4:10021025 SLC2A9 0.48 8.49 0.46 1.45e-15 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08836144 chr11:66886918 KDM2A -0.57 -6.02 -0.35 5.77e-9 Gut microbiome composition (summer); CESC cis rs7726839 0.540 rs28364691 chr5:664084 G/A cg09021430 chr5:549028 NA -0.42 -5.16 -0.3 4.75e-7 Obesity-related traits; CESC cis rs1707322 0.650 rs4553239 chr1:46150486 C/A cg05343316 chr1:45956843 TESK2 0.49 6.02 0.35 5.64e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs950776 0.593 rs555018 chr15:78879242 G/A cg24631222 chr15:78858424 CHRNA5 0.44 5.51 0.32 8.68e-8 Sudden cardiac arrest; CESC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg06873352 chr17:61820015 STRADA -0.72 -12.84 -0.62 1.11e-29 Prudent dietary pattern; CESC cis rs2795502 1.000 rs2795508 chr10:43353555 G/T cg27426351 chr10:43362370 NA 0.4 5.16 0.3 4.74e-7 Blood protein levels; CESC cis rs11098499 0.954 rs9685777 chr4:120365965 C/A cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.39 -0.37 7.41e-10 Depression; CESC cis rs7186908 0.761 rs34714490 chr16:72177099 G/T cg01557791 chr16:72042693 DHODH -0.63 -7.02 -0.4 1.83e-11 Liver enzyme levels (alkaline phosphatase); CESC cis rs863345 0.535 rs12064570 chr1:158499631 T/C cg12129480 chr1:158549410 OR10X1 -0.32 -6.15 -0.35 2.82e-9 Pneumococcal bacteremia; CESC cis rs9911578 1.000 rs12449365 chr17:56600660 C/G cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.48 0.42 1.09e-12 Tonsillectomy; CESC cis rs7116495 0.609 rs1892920 chr11:71702431 A/G cg07596299 chr11:71824057 C11orf51 -0.8 -5.3 -0.31 2.47e-7 Severe influenza A (H1N1) infection; CESC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg24531977 chr5:56204891 C5orf35 -0.83 -11.11 -0.56 8.79e-24 Initial pursuit acceleration; CESC cis rs72781680 0.752 rs72796116 chr2:23913769 C/T cg08917208 chr2:24149416 ATAD2B 1.13 10.2 0.53 7.92e-21 Lymphocyte counts; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23661306 chr3:57541993 PDE12 -0.49 -6.29 -0.36 1.28e-9 Fibrinogen levels; CESC cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.51 0.46 1.33e-15 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg05313129 chr8:58192883 C8orf71 -0.5 -5.05 -0.3 8.06e-7 Developmental language disorder (linguistic errors); CESC cis rs9291683 0.704 rs11726271 chr4:10098192 G/A cg11266682 chr4:10021025 SLC2A9 -0.49 -8.85 -0.48 1.31e-16 Bone mineral density; CESC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg12311346 chr5:56204834 C5orf35 -0.76 -9.27 -0.49 6.68e-18 Initial pursuit acceleration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08757289 chr5:179107813 CBY3 -0.37 -6.08 -0.35 4.15e-9 Gambling; CESC cis rs3749237 0.537 rs4459909 chr3:49469217 T/C cg03060546 chr3:49711283 APEH 0.77 11.7 0.58 8.99e-26 Resting heart rate; CESC trans rs4664293 0.625 rs6722715 chr2:160525026 T/C cg00243281 chr11:2597838 KCNQ1 -0.35 -6.0 -0.35 6.35e-9 Monocyte percentage of white cells; CESC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.7 0.33 3.27e-8 Bipolar disorder; CESC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg18337363 chr3:52569053 NT5DC2 0.32 5.42 0.32 1.37e-7 Bipolar disorder; CESC cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg16386425 chr10:429943 DIP2C -0.58 -7.56 -0.42 6.78e-13 Psychosis in Alzheimer's disease; CESC cis rs921968 0.541 rs4674308 chr2:219310483 A/C cg02176678 chr2:219576539 TTLL4 0.47 8.3 0.45 5.36e-15 Mean corpuscular hemoglobin concentration; CESC cis rs2952156 0.920 rs1018246 chr17:37835240 C/T cg20243544 chr17:37824526 PNMT 0.62 8.35 0.46 3.8e-15 Asthma; CESC cis rs17253792 0.822 rs78432811 chr14:56051545 T/C cg01858014 chr14:56050164 KTN1 -0.98 -7.15 -0.4 8.47e-12 Putamen volume; CESC cis rs8114671 0.967 rs4911472 chr20:33775377 T/A cg24642439 chr20:33292090 TP53INP2 0.44 5.29 0.31 2.55e-7 Height; CESC cis rs7809950 0.815 rs62482495 chr7:106965009 A/G cg23024343 chr7:107201750 COG5 -0.56 -7.18 -0.4 6.84e-12 Coronary artery disease; CESC cis rs72781680 1.000 rs12616250 chr2:24211550 T/C cg08917208 chr2:24149416 ATAD2B 0.92 8.28 0.45 6.31e-15 Lymphocyte counts; CESC cis rs12711979 0.692 rs6751947 chr2:3820739 G/A cg17052675 chr2:3827356 NA -0.41 -6.47 -0.37 4.74e-10 Itch intensity from mosquito bite adjusted by bite size; CESC trans rs875971 0.508 rs10258739 chr7:66062935 A/T cg26939375 chr7:64535504 NA -0.5 -6.96 -0.39 2.63e-11 Aortic root size; CESC cis rs2050392 0.517 rs602966 chr10:30755853 C/T cg25182066 chr10:30743637 MAP3K8 -0.51 -7.24 -0.41 4.76e-12 Inflammatory bowel disease; CESC cis rs67311347 1.000 rs9822909 chr3:40457084 G/T cg24209194 chr3:40518798 ZNF619 0.45 5.18 0.3 4.49e-7 Renal cell carcinoma; CESC cis rs3126085 0.935 rs7533529 chr1:152176871 T/C cg26876637 chr1:152193138 HRNR 0.47 5.34 0.31 1.99e-7 Atopic dermatitis; CESC cis rs4594175 0.926 rs12323654 chr14:51630894 G/T cg23942311 chr14:51606299 NA 0.37 5.53 0.32 7.79e-8 Cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18604876 chr3:5164258 ARL8B 0.47 6.74 0.38 1e-10 Gut microbiota (bacterial taxa); CESC cis rs2439831 0.867 rs2920781 chr15:43924682 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.7 8.59 0.47 7.81e-16 Lung cancer in ever smokers; CESC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg09699651 chr6:150184138 LRP11 0.44 5.63 0.33 4.66e-8 Lung cancer; CESC cis rs1983891 1.000 rs9296365 chr6:41535379 A/G cg20194872 chr6:41519635 FOXP4 0.55 7.85 0.43 1.06e-13 Prostate cancer; CESC cis rs2637266 0.626 rs846617 chr10:78546881 A/G cg18941641 chr10:78392320 NA 0.41 7.77 0.43 1.68e-13 Pulmonary function; CESC cis rs2359239 0.519 rs8007145 chr14:75185748 T/A cg11812906 chr14:75593930 NEK9 0.46 5.54 0.32 7.3900000000000007e-08 Neuroticism (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26343667 chr3:156391915 TIPARP;LOC100287227 -0.45 -6.49 -0.37 4.15e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4629180 0.675 rs13388183 chr2:102111912 A/G cg21388029 chr2:102003306 CREG2 0.32 5.17 0.3 4.65e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs4718428 1.000 rs4718428 chr7:66421446 T/G cg25985355 chr7:65971099 NA -0.32 -5.2 -0.3 4.08e-7 Corneal structure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00023492 chr1:19970710 NBL1 0.55 6.09 0.35 3.95e-9 Gut microbiome composition (summer); CESC cis rs17376456 0.825 rs34967135 chr5:93221785 G/A cg25358565 chr5:93447407 FAM172A 1.09 10.69 0.55 2.14e-22 Diabetic retinopathy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12296079 chr11:61849674 NA -0.43 -6.06 -0.35 4.77e-9 Gambling; CESC cis rs12325245 0.536 rs12924708 chr16:58567643 G/A cg02549819 chr16:58548995 SETD6 0.96 6.42 0.37 6.42e-10 Schizophrenia; CESC cis rs3862260 0.509 rs2281493 chr1:120162787 T/C cg16322792 chr1:120165303 ZNF697 0.59 11.23 0.57 3.44e-24 Systemic lupus erythematosus; CESC cis rs1707322 1.000 rs12403666 chr1:46431621 G/A cg05343316 chr1:45956843 TESK2 0.45 5.54 0.32 7.24e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs16937 0.597 rs3862949 chr1:205103070 A/T cg00857998 chr1:205179979 DSTYK 0.39 5.26 0.31 2.94e-7 Schizophrenia; CESC cis rs897984 0.760 rs11076 chr16:30995528 A/G cg02466173 chr16:30829666 NA 0.49 8.16 0.45 1.32e-14 Dementia with Lewy bodies; CESC cis rs1712517 0.566 rs7076274 chr10:105046007 G/A cg04362960 chr10:104952993 NT5C2 -0.45 -5.42 -0.32 1.37e-7 Migraine; CESC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.23 0.41 5.08e-12 Bipolar disorder; CESC cis rs4308124 0.679 rs7600458 chr2:111963590 G/C cg04571233 chr2:111982156 NA -0.63 -6.97 -0.39 2.48e-11 Vitiligo; CESC cis rs12530845 0.945 rs7799891 chr7:135322853 T/C cg23117316 chr7:135346802 PL-5283 -0.43 -5.43 -0.32 1.26e-7 Red blood cell traits; CESC cis rs7100689 0.577 rs1417219 chr10:82041409 C/T cg00277334 chr10:82204260 NA -0.53 -6.89 -0.39 3.94e-11 Post bronchodilator FEV1; CESC trans rs11039798 0.588 rs11039818 chr11:48562120 C/T cg15704280 chr7:45808275 SEPT13 0.65 6.87 0.39 4.53e-11 Axial length; CESC cis rs10744422 1.000 rs3852536 chr12:123333824 C/T cg25930673 chr12:123319894 HIP1R -0.72 -5.72 -0.33 2.83e-8 Schizophrenia; CESC cis rs6502050 0.835 rs35070385 chr17:80128447 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.61e-10 Life satisfaction; CESC cis rs4148883 0.645 rs2851264 chr4:100029715 C/T cg12011299 chr4:100065546 ADH4 0.69 10.44 0.54 1.38e-21 Alcohol dependence; CESC cis rs796364 0.951 rs12613687 chr2:200999256 C/T cg23649088 chr2:200775458 C2orf69 -0.52 -5.09 -0.3 6.77e-7 Schizophrenia; CESC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.48 6.74 0.38 9.67e-11 Menopause (age at onset); CESC cis rs6866344 0.697 rs62392831 chr5:178134365 A/G cg03877680 chr5:178157825 ZNF354A 0.76 8.58 0.47 8.33e-16 Neutrophil percentage of white cells; CESC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg03806693 chr22:41940476 POLR3H 1.2 14.94 0.68 5.18e-37 Vitiligo; CESC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg26335602 chr6:28129616 ZNF389 0.47 5.71 0.33 2.95e-8 Depression; CESC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg17376030 chr22:41985996 PMM1 -0.77 -8.07 -0.44 2.39e-14 Crohn's disease;Inflammatory bowel disease; CESC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs4595586 0.525 rs7968458 chr12:39377139 C/A cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16349277 chr4:83323642 NA 0.47 6.63 0.38 1.93e-10 Fibrinogen levels; CESC cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg10523679 chr1:76189770 ACADM 0.65 6.17 0.35 2.56e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg23463467 chr20:60627584 TAF4 0.35 5.1 0.3 6.6e-7 Body mass index; CESC cis rs2262909 0.924 rs11085509 chr19:22204573 T/C cg11619707 chr19:22235551 ZNF257 -0.35 -5.7 -0.33 3.19e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20443613 chr6:52769353 GSTA3 -0.56 -6.41 -0.37 6.52e-10 Gut microbiome composition (summer); CESC cis rs11864453 0.826 rs12325142 chr16:72138112 G/T cg01557791 chr16:72042693 DHODH -0.51 -6.73 -0.38 1.02e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07139317 chr1:11333383 UBIAD1 0.52 6.19 0.36 2.33e-9 Gut microbiome composition (summer); CESC cis rs752010 0.746 rs10749837 chr1:42089471 T/C cg06885757 chr1:42089581 HIVEP3 0.53 9.13 0.49 1.84e-17 Lupus nephritis in systemic lupus erythematosus; CESC trans rs79976124 0.879 rs10944856 chr6:66636960 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 8.2 0.45 1.02e-14 Type 2 diabetes; CESC cis rs854765 0.547 rs9894138 chr17:17964345 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.6 -8.3 -0.45 5.22e-15 Total body bone mineral density; CESC cis rs113835537 0.502 rs7104378 chr11:66216675 A/G cg24851651 chr11:66362959 CCS 0.46 5.99 0.35 6.96e-9 Airway imaging phenotypes; CESC cis rs16854884 0.586 rs7642551 chr3:143732167 C/T cg06585982 chr3:143692056 C3orf58 0.52 7.16 0.4 7.74e-12 Economic and political preferences (feminism/equality); CESC trans rs7824557 0.527 rs2572446 chr8:11239565 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.07 -0.35 4.35e-9 Retinal vascular caliber; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg16693872 chr5:176882643 PRR7 0.44 6.0 0.35 6.3e-9 Bronchopulmonary dysplasia; CESC cis rs4077515 0.504 rs7628 chr9:139318071 A/G cg14169450 chr9:139327907 INPP5E 0.48 7.18 0.4 6.92e-12 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC trans rs7246657 1.000 rs7246657 chr19:37747108 C/T cg01833234 chr11:6592585 DNHD1 -0.52 -6.08 -0.35 4.23e-9 Coronary artery calcification; CESC cis rs6831352 0.879 rs29001196 chr4:100054116 C/T cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs1215050 0.740 rs783936 chr4:98928628 G/T cg05340658 chr4:99064831 C4orf37 -0.54 -7.23 -0.41 5.23e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2228479 0.850 rs2190808 chr16:89840856 C/T cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs6076065 0.963 rs999072 chr20:23347553 C/T cg11657817 chr20:23433608 CST11 0.35 5.2 0.3 4.04e-7 Facial morphology (factor 15, philtrum width); CESC cis rs910316 0.763 rs175042 chr14:75470833 A/T cg08847533 chr14:75593920 NEK9 -0.87 -14.71 -0.67 3.14e-36 Height; CESC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.68 0.47 4.22e-16 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25798982 chr7:129251645 NRF1 -0.5 -6.36 -0.36 8.56e-10 Fibrinogen levels; CESC cis rs6582630 0.555 rs2387598 chr12:38510472 G/A cg26384229 chr12:38710491 ALG10B -0.64 -9.42 -0.5 2.36e-18 Drug-induced liver injury (flucloxacillin); CESC cis rs16895831 0.519 rs12210135 chr6:42570156 G/T cg10605015 chr6:42532144 UBR2 -0.52 -5.96 -0.34 7.96e-9 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.16 -0.3 4.88e-7 Lung cancer; CESC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg18230493 chr5:56204884 C5orf35 0.61 8.02 0.44 3.4e-14 Initial pursuit acceleration; CESC cis rs12711979 0.509 rs12711972 chr2:3823786 T/C cg17052675 chr2:3827356 NA -0.66 -11.01 -0.56 1.79e-23 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg03467027 chr4:99064603 C4orf37 0.45 5.69 0.33 3.29e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2882667 0.858 rs13174479 chr5:138444170 G/A cg04439458 chr5:138467593 SIL1 -0.38 -5.94 -0.34 9.16e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 4.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4746818 0.892 rs2394505 chr10:70871598 A/G cg04149295 chr10:70884716 VPS26A -0.54 -5.13 -0.3 5.58e-7 Left atrial antero-posterior diameter; CESC cis rs9858542 0.953 rs3811697 chr3:49590770 C/T cg03060546 chr3:49711283 APEH -0.5 -5.89 -0.34 1.15e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg12311346 chr5:56204834 C5orf35 -0.42 -5.17 -0.3 4.53e-7 Coronary artery disease; CESC cis rs17376456 0.696 rs6860390 chr5:93494731 G/T cg25358565 chr5:93447407 FAM172A -0.51 -5.93 -0.34 9.64e-9 Diabetic retinopathy; CESC cis rs2070488 0.775 rs2300669 chr3:38541318 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.79 -12.83 -0.62 1.24e-29 Electrocardiographic conduction measures; CESC cis rs11098499 0.754 rs10212714 chr4:120254302 T/C cg24375607 chr4:120327624 NA 0.41 5.07 0.3 7.59e-7 Corneal astigmatism; CESC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg26335602 chr6:28129616 ZNF389 0.52 5.75 0.33 2.39e-8 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23492582 chr20:55926133 RAE1 -0.56 -6.28 -0.36 1.36e-9 Gut microbiome composition (summer); CESC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg22633769 chr20:60982531 CABLES2 -0.67 -8.62 -0.47 6.22e-16 Colorectal cancer; CESC cis rs796364 0.906 rs281789 chr2:200780698 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.89 8.76 0.47 2.43e-16 Schizophrenia; CESC cis rs1018836 0.923 rs13255452 chr8:91582988 A/G cg16814680 chr8:91681699 NA -0.7 -9.8 -0.52 1.52e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -7.28 -0.41 3.86e-12 Alzheimer's disease; CESC cis rs4481887 0.861 rs1339989 chr1:248511624 C/G cg00666640 chr1:248458726 OR2T12 0.36 6.15 0.35 2.91e-9 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09372928 chr1:6845395 CAMTA1 0.56 6.71 0.38 1.21e-10 Gut microbiome composition (summer); CESC cis rs9467160 1.000 rs9461012 chr6:24441844 A/G cg20631270 chr6:24437470 GPLD1 -0.46 -5.78 -0.33 2.06e-8 Liver enzyme levels; CESC cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg13902645 chr11:5959945 NA -0.63 -7.53 -0.42 8.16e-13 DNA methylation (variation); CESC cis rs1371867 0.846 rs1660317 chr8:101333252 G/T cg11906718 chr8:101322791 RNF19A 0.53 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC cis rs1008375 0.932 rs10009933 chr4:17670107 A/C cg16339924 chr4:17578868 LAP3 0.59 7.08 0.4 1.27e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg04169830 chr2:88471460 THNSL2 0.42 6.06 0.35 4.69e-9 Response to metformin (IC50); CESC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg07677032 chr17:61819896 STRADA 0.44 5.77 0.33 2.15e-8 Prudent dietary pattern; CESC cis rs6587515 0.748 rs7520511 chr1:150659692 C/A cg13175981 chr1:150552382 MCL1 0.62 5.65 0.33 4.23e-8 Pericardial adipose tissue adjusted for height and weight; CESC cis rs7116495 0.609 rs577435 chr11:71794681 C/T cg10381502 chr11:71823885 C11orf51 -1.0 -6.24 -0.36 1.74e-9 Severe influenza A (H1N1) infection; CESC cis rs7714584 1.000 rs73282234 chr5:150195924 G/C cg22134413 chr5:150180641 NA 0.6 5.56 0.32 6.61e-8 Crohn's disease; CESC cis rs1465370 0.720 rs3823579 chr7:130017374 T/C cg04743876 chr7:130013617 NA 0.31 5.86 0.34 1.38e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg18230493 chr5:56204884 C5orf35 0.7 8.79 0.48 1.89e-16 Initial pursuit acceleration; CESC trans rs61931739 0.500 rs11053242 chr12:34511625 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.55 0.42 7.05e-13 Morning vs. evening chronotype; CESC cis rs17095355 0.901 rs61881586 chr10:111758419 A/G cg00817464 chr10:111662876 XPNPEP1 -0.48 -5.6 -0.33 5.27e-8 Biliary atresia; CESC cis rs4319547 0.695 rs4758645 chr12:122946487 G/A cg05707623 chr12:122985044 ZCCHC8 -0.48 -6.03 -0.35 5.46e-9 Body mass index; CESC cis rs1008375 0.933 rs6449324 chr4:17694880 G/C cg16339924 chr4:17578868 LAP3 0.57 7.2 0.4 6.15e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs5750830 0.594 rs5757647 chr22:39775047 C/A cg01416388 chr22:39784598 NA -0.54 -7.15 -0.4 8.7e-12 Intelligence (multi-trait analysis); CESC cis rs3820068 0.705 rs72643683 chr1:15824905 C/A cg18192808 chr1:15853278 DNAJC16 0.47 5.66 0.33 3.93e-8 Systolic blood pressure; CESC cis rs7432375 0.580 rs4678442 chr3:136532971 A/G cg15507776 chr3:136538369 TMEM22 0.61 7.75 0.43 1.96e-13 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs3733585 0.699 rs7657340 chr4:9966772 A/T cg02734326 chr4:10020555 SLC2A9 -0.39 -5.58 -0.32 5.91e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3126085 0.935 rs7531094 chr1:152176850 A/G cg03465714 chr1:152285911 FLG -0.44 -5.34 -0.31 2.04e-7 Atopic dermatitis; CESC cis rs9549260 0.755 rs2701869 chr13:41157372 G/A cg21288729 chr13:41239152 FOXO1 0.61 7.57 0.42 6.17e-13 Red blood cell count; CESC cis rs6430585 0.583 rs58116536 chr2:136585323 C/T cg07169764 chr2:136633963 MCM6 1.34 19.43 0.77 6.67e-53 Corneal structure; CESC trans rs875971 0.965 rs7794930 chr7:65778546 A/C cg26939375 chr7:64535504 NA -0.45 -6.03 -0.35 5.37e-9 Aortic root size; CESC cis rs6460942 0.630 rs17671056 chr7:12390961 C/G cg02935154 chr7:12443704 VWDE -0.52 -5.31 -0.31 2.29e-7 Coronary artery disease; CESC cis rs2066819 1.000 rs77131854 chr12:56664231 C/T cg26714650 chr12:56694279 CS -1.41 -9.99 -0.52 3.69e-20 Psoriasis vulgaris; CESC cis rs6502050 0.865 rs8079388 chr17:80162798 C/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.15 -0.3 4.98e-7 Life satisfaction; CESC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg03609598 chr5:56110824 MAP3K1 -0.49 -5.36 -0.31 1.8e-7 Initial pursuit acceleration; CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -5.05 -0.3 8.43e-7 Electroencephalogram traits; CESC cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg14345882 chr6:26364793 BTN3A2 0.41 5.38 0.31 1.68e-7 Intelligence (multi-trait analysis); CESC trans rs3087243 0.755 rs231791 chr2:204701865 C/A cg01841312 chr10:38069945 NA 0.39 6.38 0.36 7.87e-10 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg22817718 chr3:128880473 ISY1 -0.46 -6.4 -0.37 6.99e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10392 0.543 rs62204117 chr20:37565335 T/C cg27552599 chr20:37590471 DHX35 0.38 5.82 0.34 1.68e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs6466055 0.720 rs10227302 chr7:105021829 C/G cg04380332 chr7:105027541 SRPK2 -0.42 -5.37 -0.31 1.74e-7 Schizophrenia; CESC cis rs4919087 1.000 rs7067835 chr10:99074649 T/C cg25902810 chr10:99078978 FRAT1 0.71 10.31 0.54 3.48e-21 Monocyte count; CESC cis rs7937682 1.000 rs10789843 chr11:111576158 C/T cg22437258 chr11:111473054 SIK2 -0.68 -7.99 -0.44 4.13e-14 Primary sclerosing cholangitis; CESC cis rs12478296 0.818 rs57194240 chr2:243011545 A/G cg06360820 chr2:242988706 NA -0.72 -9.21 -0.49 1.06e-17 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02462761 chr5:139937169 SRA1 0.57 6.63 0.38 1.86e-10 Gut microbiome composition (summer); CESC cis rs7216064 1.000 rs62084249 chr17:65874998 A/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.82 -0.48 1.55e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs17685 0.712 rs10235086 chr7:75833138 G/T cg19862616 chr7:65841803 NCRNA00174 0.8 11.31 0.57 1.78e-24 Coffee consumption;Coffee consumption (cups per day); CESC cis rs1790761 0.505 rs7941395 chr11:67347417 A/G cg00290607 chr11:67383545 NA -0.36 -5.33 -0.31 2.14e-7 Mean corpuscular volume; CESC cis rs4233366 0.585 rs3924264 chr1:161178684 C/T cg13853198 chr1:161185092 FCER1G -0.32 -5.06 -0.3 7.78e-7 Asthma; CESC cis rs2299587 0.689 rs2299588 chr8:17801725 A/G cg08627089 chr8:17753878 FGL1 -0.39 -5.07 -0.3 7.32e-7 Economic and political preferences; CESC cis rs1511802 0.666 rs4862663 chr4:187119228 T/A cg24794857 chr4:187113578 CYP4V2 0.46 5.99 0.35 6.77e-9 Blood protein levels; CESC trans rs1814175 0.645 rs11040661 chr11:49952146 G/T cg11707556 chr5:10655725 ANKRD33B -0.41 -6.15 -0.35 2.82e-9 Height; CESC cis rs929596 0.518 rs13401281 chr2:234628679 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.55 -6.93 -0.39 3.12e-11 Total bilirubin levels in HIV-1 infection; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06692641 chr19:40030326 EID2 -0.49 -6.29 -0.36 1.32e-9 Ulcerative colitis; CESC cis rs10876993 0.672 rs2640611 chr12:58037757 T/A cg18357645 chr12:58087776 OS9 0.59 9.08 0.49 2.55e-17 Celiac disease or Rheumatoid arthritis; CESC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg08888203 chr3:10149979 C3orf24 0.46 6.01 0.35 6.24e-9 Alzheimer's disease; CESC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg05368731 chr17:41323189 NBR1 0.79 11.16 0.57 5.74e-24 Menopause (age at onset); CESC cis rs4523957 0.583 rs7212589 chr17:2042393 A/G cg16513277 chr17:2031491 SMG6 -0.79 -11.73 -0.58 6.95e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs77972916 0.505 rs6756575 chr2:43528519 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -6.02 -0.35 5.74e-9 Granulocyte percentage of myeloid white cells; CESC cis rs7267979 0.727 rs2474765 chr20:25245950 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.09 0.65 4.79e-34 Liver enzyme levels (alkaline phosphatase); CESC cis rs2842992 0.714 rs2475564 chr6:160123673 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.75 8.83 0.48 1.45e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs72781680 1.000 rs72796328 chr2:24141343 A/G cg08917208 chr2:24149416 ATAD2B 1.1 9.84 0.52 1.09e-19 Lymphocyte counts; CESC cis rs6736093 0.796 rs13024271 chr2:112814326 G/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.63 -0.33 4.68e-8 Coronary artery disease; CESC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg08968635 chr6:28129556 ZNF389 0.38 5.04 0.3 8.58e-7 Depression; CESC cis rs7223966 1.000 rs6504171 chr17:61710010 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.66 -0.33 3.84e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9303280 0.806 rs2305480 chr17:38062196 G/A cg20243544 chr17:37824526 PNMT 0.53 6.87 0.39 4.54e-11 Self-reported allergy; CESC cis rs2952156 0.920 rs907090 chr17:37833632 T/C cg07936489 chr17:37558343 FBXL20 -0.62 -8.15 -0.45 1.42e-14 Asthma; CESC cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.15e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2180341 0.722 rs9388555 chr6:127576363 G/A cg24812749 chr6:127587940 RNF146 0.85 11.86 0.59 2.68e-26 Breast cancer; CESC cis rs425277 1.000 rs262651 chr1:2091397 A/G cg24578937 chr1:2090814 PRKCZ 0.55 9.48 0.5 1.47e-18 Height; CESC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg21770322 chr7:97807741 LMTK2 -0.55 -8.34 -0.46 4e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg25811766 chr13:21894605 NA 0.76 10.27 0.53 4.91e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg13880726 chr7:1868755 MAD1L1 -0.5 -5.25 -0.31 3.06e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07867325 chr3:73159953 NA -0.62 -7.43 -0.42 1.45e-12 Gut microbiome composition (summer); CESC cis rs728616 0.867 rs61860400 chr10:81723427 T/C cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9911578 0.967 rs7222789 chr17:56819853 C/G cg05425664 chr17:57184151 TRIM37 -0.49 -6.72 -0.38 1.11e-10 Intelligence (multi-trait analysis); CESC cis rs397969 0.502 rs62066352 chr17:19902002 A/G cg12073167 chr17:19770448 ULK2 -0.45 -5.08 -0.3 7.05e-7 Platelet count; CESC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg15445000 chr17:37608096 MED1 -0.4 -6.54 -0.37 3.06e-10 Glomerular filtration rate (creatinine); CESC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg04234412 chr22:24373322 LOC391322 -0.49 -6.87 -0.39 4.6e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2985684 0.802 rs10150823 chr14:50051751 C/T cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.43 -5.25 -0.31 3.09e-7 Carotid intima media thickness; CESC cis rs62064224 0.533 rs11657826 chr17:30790386 T/A cg24550644 chr17:30846204 MYO1D -0.34 -5.04 -0.3 8.63e-7 Schizophrenia; CESC cis rs7520050 0.751 rs592214 chr1:46024505 G/A cg24296786 chr1:45957014 TESK2 0.5 6.23 0.36 1.83e-9 Red blood cell count;Reticulocyte count; CESC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7267979 0.816 rs405822 chr20:25501314 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 14.8 0.67 1.56e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs963731 0.522 rs13031871 chr2:39252851 T/G cg04010122 chr2:39346883 SOS1 -0.58 -5.11 -0.3 6.03e-7 Corticobasal degeneration; CESC cis rs11958404 0.932 rs112683473 chr5:157437819 T/C cg05962755 chr5:157440814 NA 0.59 6.52 0.37 3.45e-10 IgG glycosylation; CESC cis rs77741769 0.571 rs989986 chr12:121274178 A/C cg02419362 chr12:121203948 SPPL3 0.34 5.5 0.32 8.97e-8 Mean corpuscular volume; CESC cis rs1348850 0.914 rs7573763 chr2:178249808 C/T cg22681709 chr2:178499509 PDE11A -0.41 -5.88 -0.34 1.24e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs17376456 0.569 rs7735009 chr5:93260865 T/C cg25358565 chr5:93447407 FAM172A -0.47 -5.46 -0.32 1.09e-7 Diabetic retinopathy; CESC cis rs863345 0.604 rs11265003 chr1:158490631 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC trans rs1814175 0.647 rs2903409 chr11:49953612 C/G cg03929089 chr4:120376271 NA -0.73 -9.48 -0.5 1.52e-18 Height; CESC trans rs804280 0.543 rs13261205 chr8:11791216 A/G cg15556689 chr8:8085844 FLJ10661 0.52 6.41 0.37 6.53e-10 Myopia (pathological); CESC cis rs10465746 0.780 rs11163872 chr1:84421969 G/T cg10977910 chr1:84465055 TTLL7 0.52 7.13 0.4 9.81e-12 Obesity-related traits; CESC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg05332525 chr7:65337924 VKORC1L1 0.52 6.39 0.37 7.52e-10 Calcium levels; CESC cis rs17407555 0.821 rs4292329 chr4:10144459 C/G cg11266682 chr4:10021025 SLC2A9 -0.52 -6.07 -0.35 4.35e-9 Schizophrenia (age at onset); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg13859216 chr5:137910711 HSPA9 -0.44 -6.37 -0.36 8.42e-10 Vertical cup-disc ratio; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19960880 chr10:97050830 PDLIM1 -0.5 -6.75 -0.38 9.45e-11 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00076353 chr20:442752 TBC1D20 0.55 6.11 0.35 3.52e-9 Gut microbiome composition (summer); CESC cis rs8044868 0.586 rs2070937 chr16:72089740 A/G cg01557791 chr16:72042693 DHODH -0.42 -5.69 -0.33 3.29e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs6088580 0.634 rs6088488 chr20:32992631 T/C cg06115741 chr20:33292138 TP53INP2 -0.46 -5.96 -0.34 7.8e-9 Glomerular filtration rate (creatinine); CESC cis rs11583043 0.708 rs915405 chr1:101574145 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.56 0.32 6.53e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs11203032 0.831 rs12217507 chr10:90922828 G/A cg16672925 chr10:90967113 CH25H 0.74 6.99 0.39 2.26e-11 Heart failure; CESC cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg05234568 chr11:5960015 NA -0.57 -6.71 -0.38 1.15e-10 DNA methylation (variation); CESC cis rs1048238 0.846 rs945420 chr1:16345208 G/A cg22431228 chr1:16359049 CLCNKA -0.55 -11.0 -0.56 1.96e-23 Systolic blood pressure; CESC cis rs2652834 0.851 rs16946416 chr15:63356721 A/T cg05507819 chr15:63340323 TPM1 -0.62 -6.08 -0.35 4.22e-9 HDL cholesterol; CESC cis rs71718386 1 rs71718386 chr13:41224287 CTATA/C cg21288729 chr13:41239152 FOXO1 0.66 8.55 0.47 9.85e-16 Eosinophil counts; CESC cis rs10791097 0.667 rs2155358 chr11:130740357 T/C cg12179176 chr11:130786555 SNX19 0.64 10.04 0.52 2.69e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs1850744 0.510 rs4697905 chr4:9889042 T/C cg06372015 chr11:43602000 MIR129-2 0.59 6.19 0.36 2.26e-9 Economic and political preferences; CESC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg00990874 chr7:1149470 C7orf50 -0.47 -5.06 -0.3 7.67e-7 Bronchopulmonary dysplasia; CESC trans rs875971 0.660 rs10281080 chr7:66042441 T/C cg26939375 chr7:64535504 NA -0.64 -8.62 -0.47 6.05e-16 Aortic root size; CESC cis rs8044868 0.530 rs3890860 chr16:72103409 A/G cg16558253 chr16:72132732 DHX38 -0.39 -6.0 -0.35 6.38e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11141692 chr4:111866916 NA -0.55 -6.5 -0.37 3.96e-10 Gut microbiome composition (summer); CESC trans rs9929218 0.954 rs60302411 chr16:68824220 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.14 -0.45 1.51e-14 Colorectal cancer; CESC cis rs7598759 0.548 rs11686485 chr2:232360697 C/T cg19187155 chr2:232395269 NMUR1 0.61 10.22 0.53 7.11e-21 Noise-induced hearing loss; CESC cis rs1707322 1.000 rs4660332 chr1:46461418 T/A cg03146154 chr1:46216737 IPP 0.78 10.77 0.55 1.17e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs864537 0.618 rs2995089 chr1:167431193 G/A cg22356347 chr1:167427500 CD247 -0.4 -8.24 -0.45 8.17e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg11366901 chr6:160182831 ACAT2 0.64 8.17 0.45 1.24e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.68 6.93 0.39 3.14e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6456156 0.586 rs6456154 chr6:167472256 C/T cg07741184 chr6:167504864 NA 0.36 6.21 0.36 2.01e-9 Primary biliary cholangitis; CESC cis rs11098499 0.779 rs28495013 chr4:120375831 A/C cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs7762018 1.000 rs6912959 chr6:170126224 G/A cg13891659 chr6:170190454 C6orf122;C6orf208 0.57 5.76 0.33 2.27e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02562419 chr6:159049626 TMEM181 -0.6 -7.18 -0.4 6.98e-12 Gut microbiome composition (summer); CESC cis rs9584850 0.834 rs8481 chr13:99105395 G/A cg22223119 chr13:99095684 FARP1 -0.36 -5.21 -0.31 3.73e-7 Neuroticism; CESC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg16325326 chr1:53192061 ZYG11B 0.61 9.08 0.49 2.55e-17 Monocyte count; CESC cis rs792448 0.743 rs351378 chr1:212425196 T/C cg01059126 chr1:212459029 PPP2R5A -0.42 -5.19 -0.3 4.19e-7 White blood cell count (basophil); CESC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg27286337 chr10:134555280 INPP5A 0.68 7.64 0.42 4.05e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg07677032 chr17:61819896 STRADA 0.45 6.06 0.35 4.7e-9 Prudent dietary pattern; CESC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg22105103 chr4:187893119 NA -0.49 -7.08 -0.4 1.32e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs12477438 0.501 rs12992218 chr2:99753834 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.46 0.69 7.45e-39 Chronic sinus infection; CESC cis rs12476592 0.571 rs2176415 chr2:63636568 A/C cg17519650 chr2:63277830 OTX1 -0.5 -5.31 -0.31 2.36e-7 Childhood ear infection; CESC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg11965913 chr1:205819406 PM20D1 0.81 13.52 0.64 5.03e-32 Menarche (age at onset); CESC cis rs116095464 0.510 rs55750776 chr5:230467 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.65 -0.47 5.2e-16 Breast cancer; CESC cis rs9814567 1.000 rs9863786 chr3:134247203 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.15 -0.35 2.87e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7116495 1.000 rs7930721 chr11:71737481 C/A cg26138937 chr11:71823887 C11orf51 -0.77 -6.19 -0.36 2.3e-9 Severe influenza A (H1N1) infection; CESC trans rs748404 0.578 rs507178 chr15:43610135 A/G cg24053811 chr14:70265306 SLC10A1 0.41 6.0 0.35 6.61e-9 Lung cancer; CESC cis rs4077515 0.935 rs3812565 chr9:139272502 T/C cg14019695 chr9:139328340 INPP5E 0.36 5.45 0.32 1.16e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs7223966 0.960 rs7212379 chr17:61706122 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.47 -5.57 -0.32 6.28e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2637266 0.678 rs846580 chr10:78498184 G/A cg18941641 chr10:78392320 NA 0.39 7.49 0.42 9.97e-13 Pulmonary function; CESC cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg21573476 chr21:45109991 RRP1B -0.5 -6.84 -0.39 5.38e-11 Mean corpuscular volume; CESC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg20151795 chr6:28129481 ZNF389 -0.43 -5.51 -0.32 8.59e-8 Depression; CESC trans rs17685 0.697 rs28689051 chr7:75763624 G/A cg19862616 chr7:65841803 NCRNA00174 0.79 10.91 0.56 3.92e-23 Coffee consumption;Coffee consumption (cups per day); CESC cis rs6032067 0.929 rs56131549 chr20:43842014 A/T cg10761708 chr20:43804764 PI3 0.5 5.94 0.34 8.83e-9 Blood protein levels; CESC trans rs208520 0.526 rs9351542 chr6:66788571 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -24.71 -0.84 9.81e-71 Exhaled nitric oxide output; CESC trans rs6137287 0.924 rs6047279 chr20:21142353 C/T cg18379495 chr8:37553668 ZNF703 -0.45 -6.35 -0.36 9.48e-10 Height; CESC cis rs910316 1.000 rs1047418 chr14:75605792 A/G cg08847533 chr14:75593920 NEK9 0.99 18.94 0.76 3.66e-51 Height; CESC cis rs854765 0.604 rs12948749 chr17:17949802 G/A cg09796270 chr17:17721594 SREBF1 -0.43 -6.04 -0.35 5.09e-9 Total body bone mineral density; CESC cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg07493874 chr5:1342172 CLPTM1L -0.42 -7.77 -0.43 1.68e-13 Lung cancer; CESC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg11890956 chr21:40555474 PSMG1 1.19 22.54 0.81 1.51e-63 Cognitive function; CESC cis rs8072100 0.667 rs1912485 chr17:45515678 T/G cg08085267 chr17:45401833 C17orf57 -0.52 -6.6 -0.38 2.28e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07491357 chr18:9914943 VAPA 0.45 6.06 0.35 4.73e-9 Systemic lupus erythematosus; CESC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.32 -0.31 2.21e-7 Total body bone mineral density; CESC cis rs116095464 0.558 rs73031482 chr5:227594 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.44 0.32 1.19e-7 Breast cancer; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg09379601 chr19:12992224 DNASE2 0.49 6.59 0.38 2.35e-10 Weight; CESC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg05340658 chr4:99064831 C4orf37 0.82 12.87 0.62 9.38e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.850 rs11639788 chr16:89807543 G/A cg04013166 chr16:89971882 TCF25 0.76 6.51 0.37 3.75e-10 Skin colour saturation; CESC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg11366901 chr6:160182831 ACAT2 0.76 9.31 0.5 4.95e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs10927875 0.929 rs4661674 chr1:16296039 A/G cg22431228 chr1:16359049 CLCNKA 0.38 5.86 0.34 1.41e-8 Dilated cardiomyopathy; CESC cis rs10097731 0.908 rs28550260 chr8:82025584 T/C cg25230327 chr8:82042993 NA -0.61 -7.28 -0.41 3.86e-12 Serum total protein level; CESC cis rs6448317 0.906 rs4053966 chr4:24901466 A/G cg21108841 chr4:24914750 CCDC149 -0.51 -6.45 -0.37 5.39e-10 Heschl's gyrus morphology; CESC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg05332525 chr7:65337924 VKORC1L1 0.52 6.37 0.36 8.18e-10 Aortic root size; CESC cis rs939658 0.776 rs68147688 chr15:79443848 G/A cg17916960 chr15:79447300 NA -0.36 -5.87 -0.34 1.28e-8 Refractive error; CESC cis rs6963495 0.818 rs6956249 chr7:105149743 A/T cg13798780 chr7:105162888 PUS7 0.76 7.8 0.43 1.47e-13 Bipolar disorder (body mass index interaction); CESC cis rs67311347 1.000 rs6762251 chr3:40531136 A/G cg01475735 chr3:40494733 NA 0.42 5.33 0.31 2.06e-7 Renal cell carcinoma; CESC cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg02079420 chr8:82753780 SNX16 -0.57 -7.71 -0.43 2.52e-13 Diastolic blood pressure; CESC cis rs2980439 0.870 rs2945230 chr8:8109936 A/G cg06636001 chr8:8085503 FLJ10661 0.57 7.08 0.4 1.28e-11 Neuroticism; CESC cis rs2070488 0.775 rs2051213 chr3:38560254 C/T cg24069376 chr3:38537580 EXOG 0.34 5.93 0.34 9.56e-9 Electrocardiographic conduction measures; CESC cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg13175981 chr1:150552382 MCL1 0.72 10.82 0.55 7.62e-23 Tonsillectomy; CESC cis rs4595586 0.525 rs1400279 chr12:39343825 T/A cg26384229 chr12:38710491 ALG10B 0.63 8.79 0.48 1.9e-16 Morning vs. evening chronotype; CESC cis rs11122272 0.735 rs2474631 chr1:231541341 T/A cg06096015 chr1:231504339 EGLN1 0.41 5.67 0.33 3.75e-8 Hemoglobin concentration; CESC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg10018233 chr7:150070692 REPIN1 0.4 5.47 0.32 1.06e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs1814175 0.645 rs28634872 chr11:50042175 T/A cg15704280 chr7:45808275 SEPT13 -1.0 -18.7 -0.75 2.39e-50 Height; CESC cis rs7553864 0.667 rs4656143 chr1:87605208 G/A cg17420885 chr1:87600446 LOC339524 -0.42 -5.67 -0.33 3.7e-8 Smoking behavior; CESC cis rs12900413 0.687 rs8034777 chr15:90313057 C/T cg24249390 chr15:90295951 MESP1 0.4 5.62 0.33 4.75e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs8141529 1.000 rs8141529 chr22:29269692 A/G cg02153584 chr22:29168773 CCDC117 0.46 5.73 0.33 2.72e-8 Lymphocyte counts; CESC cis rs13095912 0.962 rs34505819 chr3:185340721 C/T cg11274856 chr3:185301563 NA 0.34 5.49 0.32 9.19e-8 Systolic blood pressure; CESC cis rs10504229 0.953 rs6985942 chr8:58173412 T/C cg24829409 chr8:58192753 C8orf71 -0.62 -8.61 -0.47 6.73e-16 Developmental language disorder (linguistic errors); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07379344 chr16:70147964 PDPR -0.52 -6.27 -0.36 1.44e-9 Ulcerative colitis; CESC cis rs7843479 0.601 rs2002941 chr8:21834366 A/C cg17168535 chr8:21777572 XPO7 0.73 11.8 0.59 4.28e-26 Mean corpuscular volume; CESC cis rs3820068 0.705 rs4646103 chr1:15819827 T/A cg18192808 chr1:15853278 DNAJC16 0.48 5.81 0.34 1.77e-8 Systolic blood pressure; CESC cis rs763121 0.925 rs17032 chr22:39130843 C/G cg06022373 chr22:39101656 GTPBP1 0.88 15.38 0.69 1.34e-38 Menopause (age at onset); CESC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg16680214 chr1:154839983 KCNN3 -0.44 -6.72 -0.38 1.1e-10 Prostate cancer; CESC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.21 -0.41 5.76e-12 Developmental language disorder (linguistic errors); CESC trans rs11088226 1.000 rs2833890 chr21:33927886 A/G cg09050820 chr6:167586206 TCP10L2 -0.62 -6.58 -0.37 2.44e-10 Gastritis; CESC cis rs11785693 0.862 rs62489554 chr8:4960685 T/C cg26367366 chr8:4980734 NA 0.67 6.32 0.36 1.09e-9 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs17666538 0.585 rs6559065 chr8:623156 G/C cg02524346 chr8:600233 NA 0.84 5.97 0.34 7.53e-9 IgG glycosylation; CESC cis rs2180341 0.889 rs2000909 chr6:127711173 G/A cg24812749 chr6:127587940 RNF146 0.81 11.3 0.57 1.96e-24 Breast cancer; CESC cis rs2760061 0.626 rs594916 chr1:228133544 C/A cg02753203 chr1:228287806 NA -0.5 -7.22 -0.41 5.51e-12 Diastolic blood pressure; CESC cis rs9790314 0.846 rs7627528 chr3:160990878 A/G cg03342759 chr3:160939853 NMD3 -0.5 -7.13 -0.4 9.71e-12 Morning vs. evening chronotype; CESC cis rs4853012 1.000 rs2280643 chr2:74358286 T/C cg05776053 chr2:74358815 NA 0.42 5.17 0.3 4.65e-7 Gestational age at birth (maternal effect); CESC trans rs11098499 0.615 rs59867181 chr4:120556467 C/T cg25214090 chr10:38739885 LOC399744 -0.56 -7.97 -0.44 4.84e-14 Corneal astigmatism; CESC cis rs1559088 0.948 rs2019603 chr19:33577367 C/T cg27124370 chr19:33622961 WDR88 -0.48 -6.43 -0.37 6.02e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg04370807 chr17:29248951 ADAP2 -0.42 -6.02 -0.35 5.93e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9611565 0.559 rs132765 chr22:42008068 A/G cg03806693 chr22:41940476 POLR3H 1.1 12.65 0.61 5.01e-29 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04324509 chr3:101295624 PCNP -0.55 -6.49 -0.37 4.3e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05809890 chr11:1491432 HCCA2 0.53 7.6 0.42 5.05e-13 Fibrinogen levels; CESC cis rs2404602 0.692 rs4886503 chr15:77108874 C/T cg26408565 chr15:76604113 ETFA 0.4 5.76 0.33 2.32e-8 Blood metabolite levels; CESC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg18230493 chr5:56204884 C5orf35 -0.65 -7.83 -0.43 1.19e-13 Initial pursuit acceleration; CESC cis rs7264396 0.836 rs4911183 chr20:34181553 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.62 7.74 0.43 2.06e-13 Total cholesterol levels; CESC cis rs5769765 0.837 rs8142737 chr22:50291889 T/C cg02269571 chr22:50332266 NA -0.46 -6.1 -0.35 3.76e-9 Schizophrenia; CESC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg23048001 chr7:2026167 MAD1L1 0.43 5.76 0.33 2.39e-8 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09235138 chr15:40987404 RAD51 0.59 6.92 0.39 3.31e-11 Gut microbiome composition (summer); CESC cis rs1865721 1.000 rs62089507 chr18:73179019 C/T cg26385618 chr18:73139727 C18orf62 -0.52 -7.51 -0.42 8.78e-13 Intelligence; CESC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg22974920 chr21:40686053 BRWD1 0.46 5.33 0.31 2.07e-7 Cognitive function; CESC cis rs4523957 0.928 rs177567 chr17:2197637 A/G cg16513277 chr17:2031491 SMG6 -0.6 -8.33 -0.46 4.51e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4523957 0.620 rs9912385 chr17:2062591 T/G cg16513277 chr17:2031491 SMG6 -0.72 -10.2 -0.53 8.12e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1018836 0.886 rs12545351 chr8:91636668 C/T cg16814680 chr8:91681699 NA -0.73 -11.15 -0.57 6.08e-24 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.05 0.3 8.23e-7 Colonoscopy-negative controls vs population controls; CESC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.95 9.59 0.51 7e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9815354 1.000 rs73081364 chr3:41913616 G/C cg03022575 chr3:42003672 ULK4 0.57 5.88 0.34 1.2e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs9323205 1.000 rs7149022 chr14:51613980 A/C cg23942311 chr14:51606299 NA -0.45 -5.75 -0.33 2.5e-8 Cancer; CESC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg26818010 chr10:134567672 INPP5A -0.87 -10.51 -0.54 8.06e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg00149659 chr3:10157352 C3orf10 0.7 8.27 0.45 6.42e-15 Alzheimer's disease; CESC cis rs703842 0.616 rs10783851 chr12:58231155 A/G cg02175503 chr12:58329896 NA -0.48 -5.76 -0.33 2.29e-8 Multiple sclerosis; CESC cis rs9811920 0.599 rs1688758 chr3:99539890 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 5.4 0.31 1.48e-7 Axial length; CESC cis rs829883 0.659 rs11109521 chr12:98930809 C/A cg25150519 chr12:98850993 NA -0.64 -7.87 -0.44 8.8e-14 Colorectal adenoma (advanced); CESC cis rs9300255 0.516 rs6488868 chr12:123799974 A/G cg00376283 chr12:123451042 ABCB9 0.55 6.6 0.38 2.19e-10 Neutrophil percentage of white cells; CESC cis rs3820928 0.874 rs1917125 chr2:227798981 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.75 -0.33 2.45e-8 Pulmonary function; CESC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.33 0.5 4.32e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs561341 0.714 rs473535 chr17:30312365 A/G cg20587970 chr11:113659929 NA -1.36 -16.67 -0.72 3.75e-43 Hip circumference adjusted for BMI; CESC cis rs780094 0.585 rs7586601 chr2:27584666 A/G cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.39 -0.31 1.57e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6500602 0.702 rs9929475 chr16:4540885 C/T cg08645402 chr16:4508243 NA -0.52 -8.01 -0.44 3.72e-14 Schizophrenia; CESC cis rs10752881 1.000 rs12403189 chr1:182983832 G/C ch.1.3577855R chr1:183094577 LAMC1 0.83 13.25 0.63 4.18e-31 Colorectal cancer; CESC cis rs4820539 0.708 rs5751591 chr22:23489042 G/A cg14186256 chr22:23484241 RTDR1 0.66 9.66 0.51 4.22e-19 Bone mineral density; CESC cis rs963731 0.522 rs7607509 chr2:39285372 A/G cg04010122 chr2:39346883 SOS1 -0.57 -5.14 -0.3 5.26e-7 Corticobasal degeneration; CESC cis rs854765 0.583 rs6502627 chr17:17849671 C/T cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg08847533 chr14:75593920 NEK9 1.0 18.93 0.76 3.73e-51 Height; CESC cis rs2404602 0.647 rs4886837 chr15:77156417 A/G cg23625390 chr15:77176239 SCAPER -0.45 -6.35 -0.36 9.29e-10 Blood metabolite levels; CESC cis rs34779708 0.931 rs10437420 chr10:35335044 A/C cg04310649 chr10:35416472 CREM 0.54 6.54 0.37 3.09e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs7680126 0.633 rs74469609 chr4:10294424 G/A cg00071950 chr4:10020882 SLC2A9 -0.53 -5.89 -0.34 1.19e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs7772486 0.776 rs4316025 chr6:146238032 C/T cg23711669 chr6:146136114 FBXO30 -0.77 -10.91 -0.56 3.81e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs300703 0.935 rs417829 chr2:206851 A/G cg21211680 chr2:198530 NA 0.8 7.84 0.43 1.1e-13 Blood protein levels; CESC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.49 -6.6 -0.38 2.28e-10 Personality dimensions; CESC cis rs2066819 1.000 rs2629447 chr12:56700809 G/A cg26734620 chr12:56694298 CS -0.92 -9.33 -0.5 4.31e-18 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01040181 chr8:146278358 C8orf33 0.54 6.4 0.37 6.89e-10 Gut microbiome composition (summer); CESC cis rs12410462 1.000 rs75198003 chr1:227623853 C/A cg23173402 chr1:227635558 NA 0.57 5.92 0.34 9.9e-9 Major depressive disorder; CESC cis rs798554 0.704 rs798531 chr7:2770067 G/C cg19717773 chr7:2847554 GNA12 -0.56 -8.81 -0.48 1.66e-16 Height; CESC cis rs5753618 0.561 rs737684 chr22:31659827 C/G cg13145458 chr22:31556086 RNF185 0.46 5.24 0.31 3.26e-7 Colorectal cancer; CESC cis rs5758659 0.714 rs6002607 chr22:42496506 C/T cg05082376 chr22:42548792 NA 0.36 5.23 0.31 3.46e-7 Cognitive function; CESC cis rs919433 0.889 rs788004 chr2:198219032 C/T cg10820045 chr2:198174542 NA 0.39 5.78 0.33 2.05e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4973397 0.643 rs2034413 chr2:232288149 C/T cg09339159 chr2:232260559 B3GNT7 0.51 6.25 0.36 1.59e-9 Anti-saccade response; CESC cis rs4555082 0.834 rs28489970 chr14:105748862 T/C cg13114125 chr14:105738426 BRF1 -0.86 -10.36 -0.54 2.37e-21 Mean platelet volume;Platelet distribution width; CESC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg11644478 chr21:40555479 PSMG1 1.05 17.06 0.72 1.55e-44 Cognitive function; CESC cis rs778371 0.915 rs938569 chr2:233759695 C/G cg08000102 chr2:233561755 GIGYF2 0.76 11.65 0.58 1.32e-25 Schizophrenia; CESC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg07414643 chr4:187882934 NA 0.57 8.41 0.46 2.53e-15 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg00166722 chr3:10149974 C3orf24 0.46 5.95 0.34 8.35e-9 Alzheimer's disease; CESC cis rs1018836 0.608 rs10094978 chr8:91509054 C/T cg16814680 chr8:91681699 NA -0.55 -7.74 -0.43 2.15e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs67460515 0.500 rs9860537 chr3:160660500 G/T cg03342759 chr3:160939853 NMD3 0.45 5.45 0.32 1.17e-7 Parkinson's disease; CESC cis rs7590368 0.673 rs17365209 chr2:10939117 C/T cg15705551 chr2:10952987 PDIA6 0.54 5.2 0.3 4.08e-7 Educational attainment (years of education); CESC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg22823121 chr1:150693482 HORMAD1 0.48 7.06 0.4 1.48e-11 Tonsillectomy; CESC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg18252515 chr7:66147081 NA -0.39 -5.12 -0.3 5.92e-7 Aortic root size; CESC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg18190219 chr22:46762943 CELSR1 -0.61 -6.68 -0.38 1.37e-10 LDL cholesterol;Cholesterol, total; CESC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg22920501 chr2:26401640 FAM59B -0.92 -11.65 -0.58 1.33e-25 Gut microbiome composition (summer); CESC trans rs11098499 1.000 rs7659194 chr4:120207147 T/G cg25214090 chr10:38739885 LOC399744 0.67 9.18 0.49 1.26e-17 Corneal astigmatism; CESC cis rs8018967 0.622 rs2041073 chr14:73972535 C/T cg09844916 chr14:74004424 HEATR4;ACOT1 -0.44 -5.48 -0.32 1.01e-7 Blood metabolite ratios; CESC cis rs941873 0.868 rs2233718 chr10:81108956 A/G cg08514558 chr10:81106712 PPIF 0.32 5.49 0.32 9.19e-8 Height; CESC cis rs4975616 0.804 rs462608 chr5:1336626 T/A cg07493874 chr5:1342172 CLPTM1L -0.4 -7.5 -0.42 9.41e-13 Lung cancer; CESC cis rs6696846 0.791 rs7520752 chr1:205054114 C/T cg00857998 chr1:205179979 DSTYK -0.53 -6.98 -0.39 2.42e-11 Red blood cell count; CESC cis rs10129255 0.500 rs6576225 chr14:107186359 G/C cg07958169 chr14:107095056 NA -0.54 -8.49 -0.46 1.51e-15 Kawasaki disease; CESC cis rs9303401 0.580 rs2013166 chr17:56637630 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.56e-29 Cognitive test performance; CESC cis rs1799949 0.930 rs34210004 chr17:41370337 A/T cg05368731 chr17:41323189 NBR1 0.58 7.83 0.43 1.18e-13 Menopause (age at onset); CESC cis rs6424115 0.867 rs34902309 chr1:24192200 A/G cg10978503 chr1:24200527 CNR2 -0.29 -5.67 -0.33 3.78e-8 Immature fraction of reticulocytes; CESC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg00166722 chr3:10149974 C3orf24 0.47 5.95 0.34 8.68e-9 Alzheimer's disease; CESC cis rs7223966 1.000 rs8081612 chr17:61724695 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.46 5.56 0.32 6.44e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4561483 0.603 rs7202065 chr16:11951045 C/T cg08843971 chr16:11963173 GSPT1 0.47 6.49 0.37 4.25e-10 Testicular germ cell tumor; CESC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.05e-12 Total body bone mineral density; CESC trans rs208520 0.690 rs1885100 chr6:66871047 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -13.06 -0.63 1.94e-30 Exhaled nitric oxide output; CESC cis rs9811920 0.638 rs10936008 chr3:99686665 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.57 9.11 0.49 2.08e-17 Axial length; CESC cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg21573476 chr21:45109991 RRP1B -0.55 -7.58 -0.42 6.01e-13 Mean corpuscular volume; CESC cis rs728616 0.614 rs61859191 chr10:82091027 T/C cg05935833 chr10:81318306 SFTPA2 -0.47 -5.98 -0.34 7.22e-9 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg00129232 chr17:37814104 STARD3 0.57 7.44 0.42 1.38e-12 Glomerular filtration rate (creatinine); CESC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg12311346 chr5:56204834 C5orf35 -0.6 -7.41 -0.41 1.73e-12 Initial pursuit acceleration; CESC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg24675658 chr1:53192096 ZYG11B -0.54 -6.64 -0.38 1.78e-10 Monocyte count; CESC cis rs35995292 0.500 rs2392606 chr7:38926955 C/A cg19327137 chr7:38886074 VPS41 0.67 11.08 0.56 1.1e-23 Subjective well-being (multi-trait analysis); CESC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.91 0.34 1.03e-8 Tonsillectomy; CESC cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg22467129 chr15:76604101 ETFA -0.38 -5.67 -0.33 3.78e-8 Blood metabolite levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00873521 chr9:95056130 IARS;SNORA84 -0.47 -6.11 -0.35 3.51e-9 Height; CESC cis rs644799 1.000 rs1944074 chr11:95511445 C/A cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.89 0.39 4e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6088590 1.000 rs6088607 chr20:33378733 C/T cg24642439 chr20:33292090 TP53INP2 0.84 11.75 0.59 6.33e-26 Coronary artery disease; CESC cis rs6499188 0.522 rs10153230 chr16:68671741 C/G cg02972257 chr16:68554789 NA -0.61 -7.18 -0.4 7.07e-12 Ulcerative colitis; CESC cis rs7959452 0.530 rs12811632 chr12:69755003 G/A cg22834771 chr12:69754056 YEATS4 -0.46 -6.11 -0.35 3.64e-9 Blood protein levels; CESC cis rs16867321 0.901 rs768116 chr2:181511012 A/G cg23363182 chr2:181467187 NA -0.45 -5.65 -0.33 4.19e-8 Obesity; CESC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.71 0.62 3.31e-29 Gut microbiome composition (summer); CESC cis rs10779751 1.000 rs1135172 chr1:11301714 C/T cg08854313 chr1:11322531 MTOR -0.83 -11.94 -0.59 1.38e-26 Body mass index; CESC cis rs870825 0.721 rs72703528 chr4:185607311 A/G cg04058563 chr4:185651563 MLF1IP 0.6 5.43 0.32 1.28e-7 Blood protein levels; CESC cis rs1003719 0.680 rs1034357 chr21:38571482 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.58e-15 Eye color traits; CESC cis rs950169 0.840 rs2896002 chr15:84945121 A/G cg17507749 chr15:85114479 UBE2QP1 0.6 6.65 0.38 1.66e-10 Schizophrenia; CESC cis rs709400 1.000 rs861536 chr14:104167564 A/G cg12935359 chr14:103987150 CKB -0.47 -6.25 -0.36 1.59e-9 Body mass index; CESC cis rs11577318 0.853 rs12743998 chr1:26629882 G/A cg00852783 chr1:26633632 UBXN11 0.5 6.99 0.39 2.17e-11 Granulocyte percentage of myeloid white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04346366 chr12:117257441 RNFT2 0.57 6.11 0.35 3.54e-9 Gut microbiome composition (summer); CESC trans rs1814175 0.645 rs1818895 chr11:50031523 G/T cg03929089 chr4:120376271 NA -0.91 -14.76 -0.67 2.17e-36 Height; CESC cis rs1048238 0.545 rs848199 chr1:16292742 C/T cg21385522 chr1:16154831 NA -0.46 -5.94 -0.34 9.13e-9 Systolic blood pressure; CESC cis rs9488822 0.676 rs12202181 chr6:116327102 A/G cg18764771 chr6:116381957 FRK 0.22 5.42 0.32 1.35e-7 Cholesterol, total;LDL cholesterol; CESC cis rs2180341 0.782 rs6569490 chr6:127729615 C/T cg27446573 chr6:127587934 RNF146 0.83 12.03 0.59 6.99e-27 Breast cancer; CESC cis rs8060686 0.516 rs7197756 chr16:68275516 A/C cg26727032 chr16:67993705 SLC12A4 -0.6 -8.67 -0.47 4.34e-16 HDL cholesterol;Metabolic syndrome; CESC cis rs1691799 0.899 rs1177555 chr12:66727568 A/G cg16791601 chr12:66731901 HELB -0.73 -12.46 -0.61 2.25e-28 White blood cell count (basophil); CESC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg04369109 chr6:150039330 LATS1 -0.4 -5.39 -0.31 1.58e-7 Lung cancer; CESC cis rs6693567 0.565 rs698914 chr1:150298750 A/G cg09579323 chr1:150459698 TARS2 0.5 6.24 0.36 1.75e-9 Migraine; CESC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg04944784 chr2:26401820 FAM59B -0.66 -7.62 -0.42 4.62e-13 Gut microbiome composition (summer); CESC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.43 -0.32 1.3e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs8017423 0.967 rs4904662 chr14:90729427 G/A cg14092571 chr14:90743983 NA -0.56 -8.38 -0.46 3.07e-15 Mortality in heart failure; CESC trans rs11088226 0.846 rs13047501 chr21:33924660 G/A cg09050820 chr6:167586206 TCP10L2 0.63 6.85 0.39 5.21e-11 Gastritis; CESC cis rs7633770 0.841 rs11709020 chr3:46680063 A/G cg11219411 chr3:46661640 NA -0.37 -5.2 -0.3 4.04e-7 Coronary artery disease; CESC cis rs3796352 1.000 rs11718538 chr3:52975987 C/G cg12962167 chr3:53033115 SFMBT1 0.6 5.09 0.3 6.95e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs4472734 1.000 rs11120326 chr1:214626321 T/C cg00063699 chr1:214624242 PTPN14 -0.33 -5.11 -0.3 6.06e-7 Height; CESC cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg10556349 chr10:835070 NA 0.59 5.46 0.32 1.11e-7 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01923523 chr1:3712654 LRRC47 0.57 6.68 0.38 1.41e-10 Gut microbiome composition (summer); CESC cis rs72945132 0.823 rs12292240 chr11:70152612 T/C cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs748404 0.660 rs690367 chr15:43748304 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.58 -7.46 -0.42 1.24e-12 Lung cancer; CESC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg13902645 chr11:5959945 NA -0.67 -9.87 -0.52 8.74e-20 DNA methylation (variation); CESC cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg23018236 chr17:30244563 NA -0.54 -5.08 -0.3 7.28e-7 Hip circumference adjusted for BMI; CESC cis rs2637266 0.538 rs11001850 chr10:78425431 C/T cg18941641 chr10:78392320 NA -0.32 -5.12 -0.3 5.81e-7 Pulmonary function; CESC cis rs208520 0.690 rs207082 chr6:66773796 G/A cg07460842 chr6:66804631 NA -0.98 -12.95 -0.62 4.75e-30 Exhaled nitric oxide output; CESC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.64 -0.51 4.86e-19 Alzheimer's disease; CESC cis rs9346455 0.614 rs9354989 chr6:72022171 T/C cg27238071 chr6:71998145 OGFRL1 0.56 5.34 0.31 2e-7 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02530705 chr16:2518497 NA 0.6 7.15 0.4 8.53e-12 Gut microbiome composition (summer); CESC cis rs28647808 0.881 rs41297211 chr9:136260721 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs7809950 1.000 rs6976607 chr7:107223401 A/C cg23024343 chr7:107201750 COG5 0.44 5.95 0.34 8.24e-9 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24601517 chr6:5004202 RPP40 -0.52 -7.37 -0.41 2.18e-12 Fibrinogen levels; CESC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg00750074 chr16:89608354 SPG7 -0.41 -6.02 -0.35 5.8e-9 Multiple myeloma (IgH translocation); CESC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 9.87 0.52 8.87e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10870270 0.956 rs4131689 chr10:133744328 A/C cg17892150 chr10:133769511 PPP2R2D 0.85 12.55 0.61 1.17e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs3092073 0.617 rs3893276 chr20:44591089 G/C cg27529037 chr20:44575021 PCIF1 -0.39 -5.15 -0.3 5.03e-7 Intelligence (multi-trait analysis); CESC cis rs7296418 0.630 rs11057238 chr12:123767971 C/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.33 -5.2 -0.3 3.9e-7 Platelet count; CESC cis rs7520050 0.966 rs2275426 chr1:46487552 G/A cg03146154 chr1:46216737 IPP -0.47 -6.03 -0.35 5.46e-9 Red blood cell count;Reticulocyte count; CESC cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.81 11.01 0.56 1.89e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg17949981 chr6:28129498 ZNF389 0.42 5.24 0.31 3.34e-7 Depression; CESC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg20151795 chr6:28129481 ZNF389 0.4 5.43 0.32 1.29e-7 Parkinson's disease; CESC cis rs12142240 0.698 rs1135459 chr1:46815930 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs11792861 0.816 rs11788336 chr9:111688387 T/C cg13535736 chr9:111863775 C9orf5 -0.46 -6.08 -0.35 4.18e-9 Menarche (age at onset); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg21601059 chr12:56122983 CD63 0.49 6.62 0.38 2.04e-10 Thyroid stimulating hormone; CESC cis rs910316 0.763 rs4556 chr14:75476071 G/C cg11812906 chr14:75593930 NEK9 0.78 12.34 0.6 6.0500000000000004e-28 Height; CESC cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg19077165 chr18:44547161 KATNAL2 0.59 8.87 0.48 1.09e-16 Personality dimensions; CESC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg26338869 chr17:61819248 STRADA -0.79 -10.55 -0.54 5.75e-22 Prudent dietary pattern; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg16698583 chr5:138534147 SIL1 -0.48 -6.23 -0.36 1.82e-9 Recombination measurement; CESC cis rs2880765 0.835 rs28874135 chr15:86031503 G/A cg19183879 chr15:85880815 NA -0.25 -5.26 -0.31 3.03e-7 Coronary artery disease; CESC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg23939001 chr4:940644 TMEM175 0.47 7.33 0.41 2.85e-12 Sjögren's syndrome; CESC trans rs1814175 0.781 rs28681334 chr11:50051177 C/T cg15704280 chr7:45808275 SEPT13 -1.05 -21.04 -0.79 1.87e-58 Height; CESC trans rs6027005 1.000 rs7261037 chr20:58196703 A/C cg19657214 chr8:6794872 DEFA4 0.87 6.01 0.35 6.02e-9 Intelligence (multi-trait analysis); CESC cis rs42648 0.837 rs10262603 chr7:89909442 G/A cg23697855 chr7:89950296 NA 0.27 5.14 0.3 5.43e-7 Homocysteine levels; CESC cis rs853679 0.882 rs9461432 chr6:28086883 T/C cg18032046 chr6:28092343 ZSCAN16 -0.73 -6.54 -0.37 3.21e-10 Depression; CESC cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.6e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7772486 0.875 rs2814866 chr6:146339414 C/A cg23711669 chr6:146136114 FBXO30 0.77 11.07 0.56 1.17e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs2230307 0.536 rs834277 chr1:100510855 T/G cg24955406 chr1:100503596 HIAT1 0.56 5.47 0.32 1.06e-7 Carotid intima media thickness; CESC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg03452623 chr4:187889614 NA -0.88 -15.96 -0.7 1.25e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs2839186 0.504 rs4347941 chr21:47938239 T/C cg12379764 chr21:47803548 PCNT 0.64 8.84 0.48 1.34e-16 Testicular germ cell tumor; CESC cis rs7772486 0.875 rs9403765 chr6:146368041 C/T cg05347473 chr6:146136440 FBXO30 -0.5 -6.46 -0.37 5.12e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4242434 0.819 rs7843128 chr8:22473465 T/C cg03733263 chr8:22462867 KIAA1967 0.87 14.35 0.66 6.02e-35 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs7210086 0.799 rs58953467 chr17:70636980 T/A cg04206342 chr17:70636940 NA -0.31 -5.48 -0.32 9.7e-8 Ulcerative colitis; CESC cis rs9790314 0.934 rs9290074 chr3:160997823 T/C cg03342759 chr3:160939853 NMD3 -0.45 -5.9 -0.34 1.08e-8 Morning vs. evening chronotype; CESC cis rs12135062 0.687 rs6685614 chr1:3108517 C/T cg21609526 chr1:3105151 PRDM16 0.35 5.56 0.32 6.49e-8 Migraine; CESC cis rs10744422 1.000 rs10744422 chr12:123336789 T/C cg25930673 chr12:123319894 HIP1R -0.83 -6.31 -0.36 1.15e-9 Schizophrenia; CESC cis rs7474896 0.583 rs10740950 chr10:38003496 C/T cg00409905 chr10:38381863 ZNF37A -0.46 -5.36 -0.31 1.85e-7 Obesity (extreme); CESC cis rs9303401 0.538 rs12603174 chr17:56489279 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.9 10.65 0.55 2.76e-22 Cognitive test performance; CESC trans rs3780486 0.505 rs10217267 chr9:33146528 T/C cg20290983 chr6:43655470 MRPS18A 0.73 11.27 0.57 2.6e-24 IgG glycosylation; CESC cis rs1371867 0.875 rs1619759 chr8:101337560 T/C cg11906718 chr8:101322791 RNF19A 0.54 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC cis rs6963495 0.719 rs73190174 chr7:105161216 T/G cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs7267979 0.546 rs8115804 chr20:25438783 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.67 -10.32 -0.54 3.3e-21 Liver enzyme levels (alkaline phosphatase); CESC cis rs12410462 0.581 rs7547204 chr1:227560909 C/T cg04117972 chr1:227635322 NA 0.68 5.8 0.34 1.89e-8 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24149930 chr19:33182641 NUDT19 0.64 7.71 0.43 2.51e-13 Gut microbiome composition (summer); CESC cis rs208520 0.526 rs2881644 chr6:66803535 A/C cg07460842 chr6:66804631 NA 1.09 25.81 0.85 2.83e-74 Exhaled nitric oxide output; CESC cis rs7520050 0.966 rs4134386 chr1:46395089 G/A cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.64e-8 Red blood cell count;Reticulocyte count; CESC cis rs853679 0.599 rs156743 chr6:27967089 T/C cg18032046 chr6:28092343 ZSCAN16 -0.72 -5.75 -0.33 2.48e-8 Depression; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23868848 chr8:128806661 PVT1 -0.51 -6.26 -0.36 1.55e-9 Ulcerative colitis; CESC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg11644478 chr21:40555479 PSMG1 -0.83 -12.81 -0.62 1.5e-29 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26468205 chr20:62886904 PCMTD2 0.56 6.45 0.37 5.36e-10 Gut microbiome composition (summer); CESC cis rs1322639 0.614 rs6925188 chr6:169563337 T/C cg04662567 chr6:169592167 NA -0.49 -5.12 -0.3 5.81e-7 Pulse pressure; CESC trans rs7824557 0.564 rs2736294 chr8:11234626 T/C cg06636001 chr8:8085503 FLJ10661 -0.48 -6.0 -0.35 6.44e-9 Retinal vascular caliber; CESC cis rs7582720 1.000 rs72932553 chr2:203842661 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6502050 0.805 rs4789721 chr17:80157453 T/C cg23985595 chr17:80112537 CCDC57 -0.4 -6.37 -0.36 8.38e-10 Life satisfaction; CESC cis rs2439831 1.000 rs2251538 chr15:43767209 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.82 11.93 0.59 1.53e-26 Lung cancer in ever smokers; CESC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg17971929 chr21:40555470 PSMG1 1.07 16.52 0.71 1.23e-42 Cognitive function; CESC cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg08508325 chr11:3079039 CARS 0.52 10.03 0.52 2.78e-20 Longevity; CESC cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg01579765 chr21:45077557 HSF2BP -0.57 -9.92 -0.52 6.26e-20 Mean corpuscular volume; CESC cis rs8177179 0.967 rs4287912 chr3:133437778 A/G cg24879335 chr3:133465180 TF 0.4 7.63 0.42 4.26e-13 Iron status biomarkers (transferrin levels); CESC cis rs9911578 0.740 rs368243 chr17:56708979 T/C cg12560992 chr17:57184187 TRIM37 0.82 12.27 0.6 1.02e-27 Intelligence (multi-trait analysis); CESC cis rs4253772 0.591 rs10854854 chr22:46684706 C/G cg24881330 chr22:46731750 TRMU 0.68 5.79 0.34 1.96e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7914558 0.966 rs10786721 chr10:104654383 C/A cg04362960 chr10:104952993 NT5C2 0.46 5.99 0.35 6.65e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1348850 0.567 rs7605493 chr2:178534983 C/G cg23306229 chr2:178417860 TTC30B 0.53 6.37 0.36 8.45e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7246657 0.943 rs9917081 chr19:37876616 T/C cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs909674 0.775 rs8138462 chr22:39839670 G/C cg24399712 chr22:39784796 NA -0.81 -11.18 -0.57 5.03e-24 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs3096299 0.591 rs748940 chr16:89440757 T/A cg16743903 chr16:89593216 SPG7 -0.43 -5.35 -0.31 1.9e-7 Multiple myeloma (IgH translocation); CESC cis rs1865721 0.771 rs7235563 chr18:73139335 C/G cg26385618 chr18:73139727 C18orf62 -0.49 -8.09 -0.44 2.19e-14 Intelligence; CESC cis rs3812762 0.879 rs10743089 chr11:8788168 A/T cg03980550 chr11:8754370 ST5 -0.35 -5.22 -0.31 3.64e-7 Hypospadias; CESC cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg12927641 chr6:109611667 NA -0.4 -6.27 -0.36 1.44e-9 Reticulocyte fraction of red cells; CESC cis rs17376456 0.877 rs10060462 chr5:93455073 C/T cg25358565 chr5:93447407 FAM172A 1.19 11.28 0.57 2.31e-24 Diabetic retinopathy; CESC cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8018808 0.935 rs11625365 chr14:77908588 A/G cg20045696 chr14:77926864 AHSA1 0.42 5.79 0.33 2.03e-8 Myeloid white cell count; CESC cis rs8141529 0.748 rs132531 chr22:29297365 C/T cg02153584 chr22:29168773 CCDC117 -0.56 -7.38 -0.41 2.07e-12 Lymphocyte counts; CESC cis rs1348850 0.914 rs9789582 chr2:178330173 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.89 12.61 0.61 6.89e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg21951975 chr1:209979733 IRF6 -0.61 -9.24 -0.49 8.52e-18 Cleft lip with or without cleft palate; CESC cis rs11764590 0.694 rs4721321 chr7:2068470 A/G cg21782813 chr7:2030301 MAD1L1 -0.41 -5.48 -0.32 9.8e-8 Neuroticism; CESC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg08888203 chr3:10149979 C3orf24 0.48 6.0 0.35 6.3e-9 Alzheimer's disease; CESC cis rs7903847 0.642 rs11817852 chr10:99158426 C/T cg20016023 chr10:99160130 RRP12 -0.3 -5.16 -0.3 4.81e-7 Granulocyte percentage of myeloid white cells; CESC cis rs1971256 0.500 rs80285688 chr6:151818830 G/T cg10883421 chr6:151773342 RMND1;C6orf211 0.65 6.05 0.35 4.8e-9 Endometriosis; CESC cis rs10484885 0.878 rs72921916 chr6:90555990 C/T cg13799429 chr6:90582589 CASP8AP2 -0.76 -7.22 -0.41 5.66e-12 QRS interval (sulfonylurea treatment interaction); CESC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC trans rs308403 0.506 rs309365 chr4:123659343 C/T cg18677716 chr21:47865349 PCNT -0.48 -6.03 -0.35 5.56e-9 Blood protein levels; CESC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg11764359 chr7:65958608 NA 0.47 5.87 0.34 1.33e-8 Calcium levels; CESC cis rs7296418 0.699 rs11057254 chr12:123794581 A/C cg05973401 chr12:123451056 ABCB9 0.43 5.44 0.32 1.2e-7 Platelet count; CESC cis rs6723226 0.638 rs6543657 chr2:32705085 T/C cg02381751 chr2:32503542 YIPF4 0.66 8.54 0.46 1.07e-15 Intelligence (multi-trait analysis); CESC cis rs11677416 1.000 rs1040193 chr2:113530099 C/T cg27083787 chr2:113543245 IL1A 0.58 7.26 0.41 4.23e-12 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg24250549 chr1:154909240 PMVK 0.75 11.2 0.57 4.32e-24 Prostate cancer; CESC cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg13902645 chr11:5959945 NA -0.67 -8.03 -0.44 3.21e-14 DNA methylation (variation); CESC cis rs1707322 0.964 rs785516 chr1:46564758 T/G cg05343316 chr1:45956843 TESK2 -0.47 -5.52 -0.32 7.97e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10751667 0.643 rs10794350 chr11:946070 A/G cg06064525 chr11:970664 AP2A2 -0.54 -10.79 -0.55 9.5e-23 Alzheimer's disease (late onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03016991 chr12:109124380 CORO1C 0.44 6.21 0.36 2e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1707322 0.721 rs11211166 chr1:46157942 G/A cg05343316 chr1:45956843 TESK2 0.51 6.22 0.36 1.96e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26973045 chr18:77711805 PQLC1 0.54 6.19 0.36 2.25e-9 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs5750677 chr22:39147715 C/T cg06544989 chr22:39130855 UNC84B 0.5 8.92 0.48 7.59e-17 Menopause (age at onset); CESC cis rs4268898 0.931 rs7603997 chr2:24524958 C/T cg06627628 chr2:24431161 ITSN2 -0.71 -8.6 -0.47 7.33e-16 Asthma; CESC cis rs853679 0.882 rs9468300 chr6:28126840 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.79 6.93 0.39 3.13e-11 Depression; CESC cis rs12477438 0.520 rs6542870 chr2:99796638 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.21 0.68 5.36e-38 Chronic sinus infection; CESC cis rs698833 0.813 rs3768919 chr2:44512971 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.57 7.26 0.41 4.19e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg21407906 chr20:61427925 C20orf20 -0.41 -6.11 -0.35 3.51e-9 Breast cancer; CESC cis rs9905704 0.633 rs757484 chr17:56457097 C/G cg12560992 chr17:57184187 TRIM37 -0.61 -5.75 -0.33 2.49e-8 Testicular germ cell tumor; CESC trans rs7726839 0.540 rs4957081 chr5:646418 G/C cg25482853 chr8:67687455 SGK3 0.92 9.68 0.51 3.5e-19 Obesity-related traits; CESC cis rs2382817 0.580 rs6756265 chr2:219095554 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.57 -7.45 -0.42 1.29e-12 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07546262 chr12:54753490 NA -0.52 -6.66 -0.38 1.56e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg05564831 chr3:52568323 NT5DC2 0.48 7.76 0.43 1.85e-13 Electroencephalogram traits; CESC cis rs1580019 0.547 rs56981934 chr7:32535202 C/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.55 0.37 3e-10 Cognitive ability; CESC cis rs2996428 0.667 rs10492942 chr1:3764216 C/T cg13057898 chr1:3703894 LRRC47 0.43 5.92 0.34 1.01e-8 Red cell distribution width; CESC cis rs11577318 0.853 rs4471263 chr1:26622700 C/T cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.3 -0.36 1.21e-9 Granulocyte percentage of myeloid white cells; CESC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg18876405 chr7:65276391 NA -0.53 -7.27 -0.41 4.11e-12 Aortic root size; CESC cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg24296786 chr1:45957014 TESK2 0.68 9.36 0.5 3.55e-18 High light scatter reticulocyte count; CESC cis rs1348850 0.793 rs6734528 chr2:178493731 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 6.72 0.38 1.12e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05141709 chr3:53857445 CHDH 0.49 6.13 0.35 3.23e-9 Fibrinogen levels; CESC cis rs763121 0.853 rs4821809 chr22:39065743 G/C cg14440974 chr22:39074834 NA -0.41 -5.59 -0.32 5.61e-8 Menopause (age at onset); CESC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg22903471 chr2:27725779 GCKR -0.52 -7.37 -0.41 2.21e-12 Total body bone mineral density; CESC cis rs7267979 0.899 rs2179459 chr20:25456141 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.73 12.55 0.61 1.1e-28 Liver enzyme levels (alkaline phosphatase); CESC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.51 -6.69 -0.38 1.32e-10 Bipolar disorder; CESC cis rs7216064 1.000 rs4318247 chr17:65882172 A/G cg07042672 chr17:66097459 LOC651250 -0.52 -5.4 -0.31 1.5e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs752010 0.695 rs10789408 chr1:42106579 T/C cg06885757 chr1:42089581 HIVEP3 0.49 7.81 0.43 1.37e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs12912251 0.947 rs7165988 chr15:38988815 C/G cg01338139 chr15:38987640 C15orf53 -0.47 -5.43 -0.32 1.26e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs10504229 0.679 rs73681882 chr8:58030038 A/G cg22535103 chr8:58192502 C8orf71 -0.61 -6.86 -0.39 4.87e-11 Developmental language disorder (linguistic errors); CESC cis rs854765 0.547 rs7209003 chr17:17907393 T/A cg16928487 chr17:17741425 SREBF1 -0.58 -10.22 -0.53 6.92e-21 Total body bone mineral density; CESC cis rs2370759 1.000 rs16933177 chr10:32565705 G/A cg01819863 chr10:32635814 EPC1 1.17 12.5 0.61 1.7e-28 Sexual dysfunction (female); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25793785 chr19:38281423 NA -0.57 -6.73 -0.38 1.04e-10 Gut microbiome composition (summer); CESC cis rs9911578 0.835 rs1476596 chr17:56485358 C/T cg12560992 chr17:57184187 TRIM37 0.87 14.1 0.65 4.75e-34 Intelligence (multi-trait analysis); CESC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg06420487 chr17:61919686 SMARCD2 -0.43 -5.14 -0.3 5.37e-7 Height; CESC cis rs8018808 0.935 rs8018513 chr14:77928288 T/C cg20045696 chr14:77926864 AHSA1 0.42 5.71 0.33 3.08e-8 Myeloid white cell count; CESC cis rs244293 0.931 rs2787484 chr17:53210120 C/T cg19360675 chr17:53046073 COX11;STXBP4 -0.4 -5.11 -0.3 6.03e-7 Menarche (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21209604 chr6:26032199 HIST1H3B -0.46 -6.56 -0.37 2.84e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7843479 0.524 rs1031884 chr8:21788984 C/T cg17168535 chr8:21777572 XPO7 0.8 13.33 0.63 2.25e-31 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17974674 chr2:241451567 ANKMY1 -0.64 -7.85 -0.43 1.02e-13 Gut microbiome composition (summer); CESC cis rs27434 0.607 rs26654 chr5:96140367 C/T cg16492584 chr5:96139282 ERAP1 -0.37 -5.33 -0.31 2.07e-7 Ankylosing spondylitis; CESC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg17724175 chr1:150552817 MCL1 0.33 5.08 0.3 7.16e-7 Melanoma; CESC cis rs1152591 0.543 rs1152594 chr14:64675044 C/T cg21174375 chr14:64681225 SYNE2 -0.63 -9.1 -0.49 2.21e-17 Atrial fibrillation; CESC cis rs9303401 0.614 rs2240719 chr17:56582477 G/C cg12560992 chr17:57184187 TRIM37 0.52 5.08 0.3 7.01e-7 Cognitive test performance; CESC cis rs6587515 0.892 rs11204665 chr1:150536349 A/G cg13175981 chr1:150552382 MCL1 -0.69 -5.05 -0.3 8.31e-7 Pericardial adipose tissue adjusted for height and weight; CESC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg27286337 chr10:134555280 INPP5A 0.68 7.69 0.43 2.81e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs7649739 0.894 rs9849333 chr3:65396182 C/T cg19002941 chr8:641497 ERICH1 -0.48 -6.03 -0.35 5.57e-9 IgG glycosylation; CESC cis rs4808199 0.947 rs1465695 chr19:19588546 A/C cg03709012 chr19:19516395 GATAD2A 1.13 13.2 0.63 6.29e-31 Nonalcoholic fatty liver disease; CESC cis rs897080 0.515 rs1067334 chr2:44626633 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg22133161 chr19:49891603 CCDC155 0.44 5.08 0.3 7.08e-7 Multiple sclerosis; CESC cis rs7216064 1.000 rs12451707 chr17:65871598 G/A cg12091567 chr17:66097778 LOC651250 -0.84 -8.57 -0.47 8.53e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2625529 0.586 rs2306489 chr15:72227471 G/A cg16672083 chr15:72433130 SENP8 0.42 6.37 0.36 8.12e-10 Red blood cell count; CESC cis rs4423214 0.592 rs10898223 chr11:71219264 G/A cg05163923 chr11:71159392 DHCR7 -0.62 -6.5 -0.37 3.88e-10 Vitamin D levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07058132 chr16:1755945 MAPK8IP3 0.53 6.48 0.37 4.45e-10 Gut microbiome composition (summer); CESC cis rs1878047 0.665 rs10408324 chr19:51774806 C/T cg14884932 chr19:51774451 NA -0.37 -5.16 -0.3 4.87e-7 Body mass index; CESC trans rs7937682 0.855 rs539553 chr11:111477333 C/T cg18187862 chr3:45730750 SACM1L 0.48 6.13 0.35 3.12e-9 Primary sclerosing cholangitis; CESC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg25036284 chr2:26402008 FAM59B -0.7 -8.12 -0.45 1.83e-14 Gut microbiome composition (summer); CESC cis rs12824058 0.831 rs4759658 chr12:130815872 C/T cg24838063 chr12:130822603 PIWIL1 0.63 8.58 0.47 7.91e-16 Menopause (age at onset); CESC cis rs7216064 1.000 rs1976054 chr17:65833224 T/G cg07042672 chr17:66097459 LOC651250 -0.57 -6.66 -0.38 1.59e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11122272 0.735 rs2486736 chr1:231521478 A/G cg06096015 chr1:231504339 EGLN1 -0.38 -5.43 -0.32 1.26e-7 Hemoglobin concentration; CESC cis rs7631605 0.905 rs7651903 chr3:37006686 T/C cg22985146 chr3:37219077 LRRFIP2 -0.34 -5.36 -0.31 1.82e-7 Cerebrospinal P-tau181p levels; CESC cis rs2286503 0.839 rs1054471 chr7:22852643 T/A cg13679077 chr7:22862647 TOMM7 0.45 5.77 0.33 2.2e-8 Fibrinogen; CESC cis rs3741151 0.686 rs1002127 chr11:73103835 G/C cg17517138 chr11:73019481 ARHGEF17 0.84 6.47 0.37 4.77e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7818345 0.763 rs4431609 chr8:19293565 A/C cg11303988 chr8:19266685 CSGALNACT1 -0.32 -5.43 -0.32 1.3e-7 Language performance in older adults (adjusted for episodic memory); CESC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg21951975 chr1:209979733 IRF6 0.6 9.51 0.5 1.18e-18 Cleft lip with or without cleft palate; CESC trans rs6951245 0.706 rs28522260 chr7:1183964 C/A cg13565492 chr6:43139072 SRF -0.6 -6.21 -0.36 2.06e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg05368731 chr17:41323189 NBR1 -0.58 -8.27 -0.45 6.71e-15 Menopause (age at onset); CESC cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg25405998 chr7:65216604 CCT6P1 0.5 5.52 0.32 8.16e-8 Aortic root size; CESC cis rs6496667 0.533 rs2074583 chr15:91009192 T/C cg22089800 chr15:90895588 ZNF774 0.45 5.86 0.34 1.35e-8 Rheumatoid arthritis; CESC cis rs13223928 0.631 rs12531881 chr7:3156842 C/T cg19214707 chr7:3157722 NA -0.43 -5.88 -0.34 1.26e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs2228479 0.850 rs11649100 chr16:89798179 A/G cg04013166 chr16:89971882 TCF25 0.67 5.38 0.31 1.65e-7 Skin colour saturation; CESC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg00784671 chr22:46762841 CELSR1 -0.47 -5.56 -0.32 6.45e-8 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14837817 chr8:144692253 PYCRL -0.54 -6.05 -0.35 4.95e-9 Gut microbiome composition (summer); CESC cis rs9926296 0.632 rs7184315 chr16:89799373 C/G cg27121462 chr16:89883253 FANCA -0.63 -7.94 -0.44 5.8e-14 Vitiligo; CESC cis rs2243480 1.000 rs1979823 chr7:65704613 G/A cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC trans rs6700559 0.810 rs2809344 chr1:200596606 C/A cg13401811 chr12:52345646 ACVR1B -0.47 -6.01 -0.35 6.03e-9 Coronary artery disease; CESC cis rs55665837 0.559 rs11023209 chr11:14422600 T/C cg19336497 chr11:14380999 RRAS2 -0.35 -5.23 -0.31 3.49e-7 Vitamin D levels; CESC cis rs116095464 0.558 rs73024831 chr5:257192 A/G cg22857025 chr5:266934 NA -1.29 -18.21 -0.75 1.29e-48 Breast cancer; CESC cis rs4835473 0.897 rs34425128 chr4:144646344 T/A cg25736465 chr4:144833511 NA -0.44 -6.5 -0.37 3.98e-10 Immature fraction of reticulocytes; CESC cis rs17209837 0.607 rs1558375 chr7:87079069 T/C cg00919237 chr7:87102261 ABCB4 -0.52 -6.67 -0.38 1.45e-10 Gallbladder cancer; CESC cis rs6580649 1.000 rs3825404 chr12:48399931 A/G cg05342945 chr12:48394962 COL2A1 -0.56 -6.73 -0.38 1.04e-10 Lung cancer; CESC cis rs9303401 0.614 rs3803753 chr17:56540110 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.3 0.6 8.24e-28 Cognitive test performance; CESC cis rs6570726 1.000 rs405622 chr6:145871897 G/T cg05347473 chr6:146136440 FBXO30 0.43 5.83 0.34 1.63e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.97 0.59 1.11e-26 Alzheimer's disease; CESC cis rs34779708 0.931 rs1926556 chr10:35344907 T/C cg03585969 chr10:35415529 CREM 0.75 9.67 0.51 3.92e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs1443512 0.796 rs1822437 chr12:54340077 A/G cg12374095 chr12:54320830 NA 0.44 5.88 0.34 1.24e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs4974559 0.895 rs28493051 chr4:1331030 A/C cg02980000 chr4:1222292 CTBP1 0.64 7.46 0.42 1.21e-12 Systolic blood pressure; CESC cis rs1215050 0.740 rs783929 chr4:98972495 T/A cg05340658 chr4:99064831 C4orf37 -0.54 -7.33 -0.41 2.75e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4654899 0.802 rs7519685 chr1:21192623 G/A cg05370193 chr1:21551575 ECE1 0.39 5.65 0.33 4.12e-8 Superior frontal gyrus grey matter volume; CESC cis rs2380220 0.606 rs7747776 chr6:96005852 C/T cg15832292 chr6:96025679 MANEA 0.59 6.94 0.39 2.97e-11 Behavioural disinhibition (generation interaction); CESC cis rs15676 0.783 rs2280843 chr9:131585069 A/G cg00228799 chr9:131580591 ENDOG 0.55 7.13 0.4 9.74e-12 Blood metabolite levels; CESC cis rs7089973 0.604 rs2181563 chr10:116604344 T/C cg03647239 chr10:116582469 FAM160B1 0.46 6.1 0.35 3.77e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs3093024 0.839 rs968334 chr6:167526096 T/C cg23791538 chr6:167370224 RNASET2 0.45 5.63 0.33 4.49e-8 Rheumatoid arthritis; CESC cis rs1580019 0.563 rs34201720 chr7:32568935 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.97 0.76 2.73e-51 Cognitive ability; CESC cis rs4689388 0.824 rs6446482 chr4:6295693 C/G cg00701064 chr4:6280414 WFS1 0.69 11.68 0.58 1.03e-25 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs10857712 0.950 rs10857711 chr10:135224059 G/A cg01444801 chr10:135216882 MTG1 -0.46 -5.6 -0.33 5.48e-8 Systemic lupus erythematosus; CESC trans rs9393777 0.920 rs35869525 chr6:26946687 C/T cg01620082 chr3:125678407 NA -0.81 -6.76 -0.38 8.96e-11 Intelligence (multi-trait analysis); CESC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg06456125 chr7:65229604 NA -0.4 -5.58 -0.32 5.97e-8 Aortic root size; CESC cis rs9302635 0.513 rs35460163 chr16:72177060 C/T cg16558253 chr16:72132732 DHX38 -0.42 -5.15 -0.3 5.18e-7 Blood protein levels; CESC cis rs6582630 0.555 rs7305352 chr12:38473800 T/C cg13010199 chr12:38710504 ALG10B 0.53 6.74 0.38 9.64e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs2463822 1.000 rs2513749 chr11:62105391 C/T cg06239285 chr11:62104954 ASRGL1 0.85 8.6 0.47 7.06e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs7216064 0.953 rs4791046 chr17:65851973 G/A cg12091567 chr17:66097778 LOC651250 -0.77 -8.39 -0.46 2.89e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9611519 0.566 rs4821981 chr22:41415644 A/C cg03806693 chr22:41940476 POLR3H 0.51 6.02 0.35 5.76e-9 Neuroticism; CESC cis rs7267979 0.966 rs2257712 chr20:25264910 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC trans rs10242455 0.571 rs7805661 chr7:99171522 A/C cg09045935 chr12:6379348 NA 0.83 7.16 0.4 7.87e-12 Blood metabolite levels; CESC cis rs2288073 0.930 rs7604097 chr2:24401805 G/C cg06627628 chr2:24431161 ITSN2 -0.73 -8.63 -0.47 5.71e-16 Venous thromboembolism (SNP x SNP interaction); CESC trans rs11822910 0.871 rs2581928 chr11:57202790 A/G cg06103642 chr6:108496716 NR2E1 0.51 6.33 0.36 1.05e-9 Platelet distribution width; CESC cis rs1018836 0.923 rs34126139 chr8:91572045 T/G cg16814680 chr8:91681699 NA -0.66 -9.17 -0.49 1.33e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs8180040 0.966 rs60369822 chr3:47479735 A/C cg27129171 chr3:47204927 SETD2 -0.63 -9.48 -0.5 1.49e-18 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03689120 chr13:20767179 GJB2 0.56 6.33 0.36 1.06e-9 Gut microbiome composition (summer); CESC cis rs5760092 0.618 rs4461358 chr22:24260106 T/C cg04234412 chr22:24373322 LOC391322 0.66 9.02 0.48 3.88e-17 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs6430585 0.527 rs62168836 chr2:136463117 G/A cg07169764 chr2:136633963 MCM6 1.09 12.63 0.61 6.06e-29 Corneal structure; CESC cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg16339924 chr4:17578868 LAP3 -0.59 -7.06 -0.4 1.48e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.7.1147807F chr7:49473528 NA -0.57 -6.83 -0.39 5.91e-11 Gut microbiome composition (summer); CESC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg09858108 chr8:58055024 NA 0.37 5.33 0.31 2.15e-7 Developmental language disorder (linguistic errors); CESC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg17971929 chr21:40555470 PSMG1 1.07 16.35 0.71 4.96e-42 Cognitive function; CESC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg17366294 chr4:99064904 C4orf37 0.62 8.89 0.48 9.33e-17 Colonoscopy-negative controls vs population controls; CESC cis rs796364 0.664 rs3106089 chr2:200884615 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.83 7.54 0.42 7.3e-13 Schizophrenia; CESC trans rs9929218 1.000 rs8056538 chr16:68802282 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.46 -0.46 1.84e-15 Colorectal cancer; CESC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg11764359 chr7:65958608 NA -0.8 -11.72 -0.58 7.64e-26 Aortic root size; CESC cis rs9300255 0.602 rs1716168 chr12:123651966 C/G cg19016782 chr12:123741754 C12orf65 0.4 5.69 0.33 3.29e-8 Neutrophil percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03383661 chr6:42714115 TBCC -0.47 -6.82 -0.39 6.1e-11 Gambling; CESC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.48 6.05 0.35 4.83e-9 Tonsillectomy; CESC cis rs4808199 0.895 rs10419672 chr19:19471241 T/C cg03709012 chr19:19516395 GATAD2A 1.09 12.15 0.6 2.63e-27 Nonalcoholic fatty liver disease; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg07308232 chr7:1071921 C7orf50 -0.39 -5.2 -0.3 3.9e-7 Longevity;Endometriosis; CESC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg03264133 chr6:25882463 NA 0.45 6.63 0.38 1.86e-10 Intelligence (multi-trait analysis); CESC cis rs7267979 1.000 rs1047171 chr20:25428786 T/C cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.4e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs77303550 1.000 rs217181 chr16:72114002 A/G cg01557791 chr16:72042693 DHODH -0.59 -6.15 -0.35 2.86e-9 Metabolite levels (small molecules and protein measures); CESC cis rs17401966 0.928 rs11121531 chr1:10277357 G/A cg15208524 chr1:10270712 KIF1B 0.53 6.89 0.39 3.99e-11 Hepatocellular carcinoma; CESC cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9549260 0.755 rs7335520 chr13:41196407 C/T cg21288729 chr13:41239152 FOXO1 0.6 7.67 0.43 3.27e-13 Red blood cell count; CESC trans rs7178375 1.000 rs10163148 chr15:31212684 C/G cg04373760 chr16:53404718 NA 0.56 6.87 0.39 4.69e-11 Hypertriglyceridemia; CESC cis rs7084402 0.967 rs1658469 chr10:60292402 C/T cg07615347 chr10:60278583 BICC1 -0.62 -9.96 -0.52 4.59e-20 Refractive error; CESC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs10782582 0.545 rs12138018 chr1:76186794 T/C cg22875332 chr1:76189707 ACADM -0.44 -5.3 -0.31 2.41e-7 Daytime sleep phenotypes; CESC cis rs2637266 0.678 rs846604 chr10:78569223 A/G cg18941641 chr10:78392320 NA 0.39 7.54 0.42 7.31e-13 Pulmonary function; CESC cis rs12477438 0.520 rs2516835 chr2:99779131 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.62 0.61 6.6e-29 Chronic sinus infection; CESC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg07677032 chr17:61819896 STRADA 0.45 6.0 0.35 6.49e-9 Prudent dietary pattern; CESC cis rs2204008 0.805 rs10881112 chr12:37956611 G/A cg26384229 chr12:38710491 ALG10B -0.53 -7.46 -0.42 1.26e-12 Bladder cancer; CESC cis rs7264396 0.635 rs6058375 chr20:34531997 T/A cg17201900 chr20:34330562 RBM39 0.51 5.4 0.31 1.5e-7 Total cholesterol levels; CESC cis rs4664308 0.935 rs4665148 chr2:160917901 A/G cg03641300 chr2:160917029 PLA2R1 -0.67 -10.08 -0.53 1.88e-20 Idiopathic membranous nephropathy; CESC cis rs7188697 0.769 rs9932944 chr16:58616165 C/T cg21335942 chr16:58549945 SETD6 -0.45 -5.17 -0.3 4.73e-7 QT interval; CESC cis rs60843830 0.661 rs62116682 chr2:104618 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.51 6.08 0.35 4.11e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs6088580 0.634 rs6059880 chr20:33088669 G/A cg24642439 chr20:33292090 TP53INP2 0.49 6.4 0.37 7.03e-10 Glomerular filtration rate (creatinine); CESC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg04511125 chr2:88470314 THNSL2 0.68 6.66 0.38 1.61e-10 Plasma clusterin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12528016 chr1:27998711 IFI6 0.57 6.13 0.35 3.2e-9 Gut microbiome composition (summer); CESC cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg20476274 chr7:133979776 SLC35B4 0.68 9.87 0.52 8.91e-20 Mean platelet volume; CESC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC trans rs7819412 0.668 rs2409715 chr8:11010136 A/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.01 -0.35 6.2e-9 Triglycerides; CESC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg22920501 chr2:26401640 FAM59B 0.91 10.33 0.54 3.07e-21 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07852735 chr8:63951642 GGH 0.59 6.58 0.37 2.53e-10 Gut microbiome composition (summer); CESC trans rs8026198 0.568 rs1659218 chr15:42616073 A/T cg11538410 chr8:142141455 DENND3 0.61 6.02 0.35 5.66e-9 Fibrinogen levels; CESC cis rs548181 0.673 rs12288034 chr11:125570941 A/T cg03464685 chr11:125439445 EI24 -0.73 -6.24 -0.36 1.76e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs208520 0.526 rs2881644 chr6:66803535 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.07 23.24 0.82 6.96e-66 Exhaled nitric oxide output; CESC cis rs9309473 0.848 rs9750915 chr2:73811880 T/C cg20560298 chr2:73613845 ALMS1 -0.54 -7.04 -0.4 1.64e-11 Metabolite levels; CESC cis rs11098499 0.954 rs7654587 chr4:120388406 C/T cg24375607 chr4:120327624 NA 0.44 5.48 0.32 9.91e-8 Corneal astigmatism; CESC cis rs2952156 0.920 rs12150298 chr17:37834541 T/C cg19468946 chr17:37922297 IKZF3 -0.4 -5.28 -0.31 2.75e-7 Asthma; CESC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12478296 1.000 rs55758933 chr2:243040289 T/C cg06360820 chr2:242988706 NA -0.66 -7.52 -0.42 8.51e-13 Obesity-related traits; CESC cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs13064411 0.696 rs6769516 chr3:113219905 T/C cg18753928 chr3:113234510 CCDC52 -0.51 -6.22 -0.36 1.9e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs4595586 0.545 rs6580896 chr12:39372223 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07079059 chr17:33569328 SLFN5 -0.58 -6.68 -0.38 1.39e-10 Gut microbiome composition (summer); CESC cis rs727505 1.000 rs7801661 chr7:124483222 C/T cg23710748 chr7:124431027 NA 0.48 7.65 0.43 3.62e-13 Lewy body disease; CESC cis rs7107174 1.000 rs10899475 chr11:78051610 T/C cg02023728 chr11:77925099 USP35 0.38 5.39 0.31 1.57e-7 Testicular germ cell tumor; CESC cis rs1538970 0.924 rs4660855 chr1:45899795 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.46 0.32 1.11e-7 Platelet count; CESC cis rs111326718 1 rs111326718 chr10:104771211 A/AAAAAT cg04362960 chr10:104952993 NT5C2 0.44 5.82 0.34 1.67e-8 Reticulocyte count; CESC cis rs1003719 0.715 rs2156077 chr21:38539357 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.98 -0.44 4.49e-14 Eye color traits; CESC cis rs17253792 0.822 rs112374071 chr14:56061919 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.88 5.69 0.33 3.38e-8 Putamen volume; CESC cis rs6987853 0.865 rs2923445 chr8:42400743 C/A cg09913449 chr8:42400586 C8orf40 0.4 6.34 0.36 9.76e-10 Mean corpuscular hemoglobin concentration; CESC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg14829155 chr15:31115871 NA -0.7 -9.48 -0.5 1.52e-18 Huntington's disease progression; CESC cis rs950776 0.518 rs12906846 chr15:78825295 G/A cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs6963495 0.818 rs6943132 chr7:105166776 C/T cg13798780 chr7:105162888 PUS7 0.8 6.56 0.37 2.76e-10 Bipolar disorder (body mass index interaction); CESC cis rs7659604 1.000 rs6846232 chr4:122664805 A/G cg19671926 chr4:122722719 EXOSC9 -0.44 -5.3 -0.31 2.49e-7 Type 2 diabetes; CESC trans rs1814175 0.817 rs1319547 chr11:49916705 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -20.27 -0.78 8.31e-56 Height; CESC cis rs6545883 0.859 rs2600661 chr2:61543081 T/C cg15711740 chr2:61764176 XPO1 0.41 5.12 0.3 5.78e-7 Tuberculosis; CESC cis rs9549260 0.755 rs9549241 chr13:41210041 G/A cg21288729 chr13:41239152 FOXO1 0.63 8.41 0.46 2.55e-15 Red blood cell count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14275457 chr9:132934675 FREQ -0.41 -6.18 -0.35 2.43e-9 Gambling; CESC cis rs9309473 1.000 rs10193972 chr2:73717656 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -6.29 -0.36 1.28e-9 Metabolite levels; CESC cis rs10129255 0.500 rs6576229 chr14:107186773 G/A cg07958169 chr14:107095056 NA -0.55 -8.65 -0.47 4.94e-16 Kawasaki disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21705506 chr17:33842181 SLFN12L -0.55 -6.51 -0.37 3.72e-10 Gut microbiome composition (summer); CESC cis rs2637266 0.703 rs2920792 chr10:78532842 A/T cg18941641 chr10:78392320 NA -0.39 -7.6 -0.42 5.12e-13 Pulmonary function; CESC cis rs644148 0.693 rs2686772 chr19:44999729 T/C cg15540054 chr19:45004280 ZNF180 -0.63 -6.74 -0.38 9.58e-11 Personality dimensions; CESC cis rs6691722 0.544 rs7551707 chr1:24696892 G/A cg18323236 chr1:24743029 NIPAL3 0.36 5.38 0.31 1.62e-7 Response to interferon beta in multiple sclerosis; CESC trans rs11039798 0.588 rs10838923 chr11:48534864 C/G cg15704280 chr7:45808275 SEPT13 0.67 7.17 0.4 7.54e-12 Axial length; CESC cis rs2014572 0.967 rs10411941 chr19:57762886 C/T cg24459738 chr19:57751996 ZNF805 -0.53 -7.54 -0.42 7.48e-13 Hyperactive-impulsive symptoms; CESC trans rs11039798 0.920 rs11040015 chr11:48783130 G/T cg15704280 chr7:45808275 SEPT13 0.7 6.51 0.37 3.81e-10 Axial length; CESC cis rs3859192 0.599 rs2227321 chr17:38171294 G/C cg17467752 chr17:38218738 THRA -0.45 -5.88 -0.34 1.2e-8 White blood cell count; CESC cis rs11098499 0.738 rs34566984 chr4:120361270 G/A cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs9486719 1.000 rs2472897 chr6:96870569 G/T cg06623918 chr6:96969491 KIAA0776 0.78 7.96 0.44 5.01e-14 Migraine;Coronary artery disease; CESC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs62229266 0.693 rs2835264 chr21:37435965 C/T cg12218747 chr21:37451666 NA -0.39 -5.41 -0.32 1.4e-7 Mitral valve prolapse; CESC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg11764359 chr7:65958608 NA -0.78 -11.61 -0.58 1.78e-25 Aortic root size; CESC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg23758822 chr17:41437982 NA 1.05 16.2 0.71 1.69e-41 Menopause (age at onset); CESC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.75 0.81 2.95e-64 Prudent dietary pattern; CESC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs5769765 0.778 rs8137331 chr22:50313358 G/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.51 -5.58 -0.32 5.93e-8 Schizophrenia; CESC trans rs11039798 0.688 rs12277029 chr11:48852833 G/T cg15704280 chr7:45808275 SEPT13 0.71 6.44 0.37 5.59e-10 Axial length; CESC cis rs826838 0.651 rs12367384 chr12:38618460 G/T cg26384229 chr12:38710491 ALG10B 0.57 8.25 0.45 7.66e-15 Heart rate; CESC cis rs4664304 0.966 rs7601374 chr2:160754050 T/C cg03641300 chr2:160917029 PLA2R1 -0.48 -6.89 -0.39 3.99e-11 Crohn's disease;Inflammatory bowel disease; CESC trans rs2488856 0.689 rs1954400 chr14:43602205 C/T cg14326805 chr9:71737756 TJP2 0.37 6.14 0.35 2.93e-9 Osteoprotegerin levels; CESC cis rs9399401 0.633 rs1329705 chr6:142753338 G/A cg04461802 chr6:142623433 GPR126 0.39 5.63 0.33 4.67e-8 Chronic obstructive pulmonary disease; CESC cis rs9467711 0.606 rs9379855 chr6:26364930 C/T cg14345882 chr6:26364793 BTN3A2 -0.56 -6.16 -0.35 2.67e-9 Autism spectrum disorder or schizophrenia; CESC cis rs4604732 0.536 rs4925674 chr1:247636906 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.46 6.18 0.35 2.47e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs9467711 0.659 rs3823158 chr6:26463271 T/A cg01620082 chr3:125678407 NA -0.74 -6.02 -0.35 5.74e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg18479299 chr3:125709523 NA -0.49 -5.44 -0.32 1.23e-7 Blood pressure (smoking interaction); CESC cis rs2479724 0.905 rs2251274 chr6:41839438 T/G cg08135965 chr6:41755394 TOMM6 0.4 5.55 0.32 6.92e-8 Menarche (age at onset); CESC cis rs72945132 0.882 rs12294540 chr11:70118973 A/T cg14191688 chr11:70257035 CTTN 0.4 5.06 0.3 8.03e-7 Coronary artery disease; CESC cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg18305652 chr10:134549665 INPP5A 0.48 7.63 0.42 4.11e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg27165867 chr14:105738592 BRF1 -0.48 -5.73 -0.33 2.72e-8 Mean platelet volume;Platelet distribution width; CESC cis rs7772486 0.654 rs1011597 chr6:146075672 A/C cg23711669 chr6:146136114 FBXO30 -0.9 -13.43 -0.64 1e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg14703610 chr5:56206110 C5orf35 0.42 5.07 0.3 7.54e-7 Coronary artery disease; CESC cis rs9457247 1.000 rs439237 chr6:167391392 A/G cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC cis rs2625529 0.586 rs7175197 chr15:72461648 G/A cg16672083 chr15:72433130 SENP8 0.5 7.48 0.42 1.11e-12 Red blood cell count; CESC cis rs863345 0.625 rs6663286 chr1:158473725 C/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.58e-11 Pneumococcal bacteremia; CESC cis rs7918232 0.830 rs7087033 chr10:27392522 A/G cg14240646 chr10:27532245 ACBD5 -0.66 -6.25 -0.36 1.64e-9 Breast cancer; CESC cis rs7727544 0.606 rs2631360 chr5:131707429 A/G cg14196790 chr5:131705035 SLC22A5 0.43 6.97 0.39 2.53e-11 Blood metabolite levels; CESC cis rs5769765 0.908 rs9616211 chr22:50317676 G/A cg26441486 chr22:50317300 CRELD2 0.48 5.75 0.33 2.44e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11885407 chr3:193310886 OPA1 0.59 6.46 0.37 5.09e-10 Gut microbiome composition (summer); CESC cis rs6963495 0.818 rs55794529 chr7:105165747 T/C cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs6570726 0.935 rs414222 chr6:145850482 C/T cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 2e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg00129232 chr17:37814104 STARD3 0.55 7.1 0.4 1.14e-11 Glomerular filtration rate (creatinine); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00450571 chr11:10716455 MRVI1 0.41 6.08 0.35 4.22e-9 Gut microbiota (bacterial taxa); CESC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg18301423 chr5:131593218 PDLIM4 0.38 5.43 0.32 1.29e-7 Breast cancer; CESC cis rs9527 0.590 rs7894959 chr10:104756182 C/T cg04362960 chr10:104952993 NT5C2 0.44 5.36 0.31 1.81e-7 Arsenic metabolism; CESC cis rs9303401 0.703 rs8072182 chr17:57211213 G/A cg12560992 chr17:57184187 TRIM37 0.47 5.73 0.33 2.71e-8 Cognitive test performance; CESC trans rs208520 0.526 rs9363522 chr6:66816642 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -23.26 -0.82 6.02e-66 Exhaled nitric oxide output; CESC cis rs6088590 0.931 rs6088617 chr20:33408036 G/A cg24642439 chr20:33292090 TP53INP2 0.84 11.62 0.58 1.67e-25 Coronary artery disease; CESC cis rs7772486 0.790 rs6917482 chr6:146243581 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -13.36 -0.63 1.78e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs1506636 1.000 rs1506636 chr7:123317140 C/T cg03229431 chr7:123269106 ASB15 0.49 6.41 0.37 6.76e-10 Plateletcrit;Platelet count; CESC cis rs11785400 1.000 rs10099892 chr8:143734608 C/T cg24634471 chr8:143751801 JRK 0.46 6.14 0.35 3.02e-9 Schizophrenia; CESC cis rs748404 0.631 rs1133395 chr15:43650384 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.65 0.43 3.83e-13 Lung cancer; CESC cis rs9303401 0.614 rs34678056 chr17:57177549 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.88 11.1 0.56 8.94e-24 Cognitive test performance; CESC cis rs7116495 0.588 rs547208 chr11:71779668 A/G cg26138937 chr11:71823887 C11orf51 -0.84 -6.68 -0.38 1.39e-10 Severe influenza A (H1N1) infection; CESC cis rs708547 0.874 rs1401190 chr4:57885174 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 7.93 0.44 5.96e-14 Response to bleomycin (chromatid breaks); CESC cis rs9300255 0.568 rs1727300 chr12:123664205 C/T cg19016782 chr12:123741754 C12orf65 -0.45 -6.4 -0.37 6.92e-10 Neutrophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17565094 chr4:124036420 SPATA5 0.49 6.85 0.39 5.14e-11 Fibrinogen levels; CESC cis rs6665290 0.669 rs7552783 chr1:227174145 T/C cg10327440 chr1:227177885 CDC42BPA -1.11 -22.82 -0.81 1.74e-64 Myeloid white cell count; CESC cis rs10832963 1.000 rs4757676 chr11:18640477 C/T cg20219074 chr11:18656078 SPTY2D1 0.8 11.77 0.59 5.17e-26 Breast cancer; CESC cis rs8070624 0.543 rs11078409 chr17:17876296 C/G cg16928487 chr17:17741425 SREBF1 -0.54 -8.64 -0.47 5.35e-16 Total body bone mineral density; CESC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg08859206 chr1:53392774 SCP2 0.64 9.36 0.5 3.66e-18 Monocyte count; CESC cis rs9908102 0.740 rs58578352 chr17:12907095 G/C cg26162695 chr17:12921313 ELAC2 0.51 5.64 0.33 4.33e-8 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08597319 chr8:103876573 AZIN1 -0.47 -6.56 -0.37 2.81e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06862150 chr5:151150984 G3BP1 0.56 6.29 0.36 1.32e-9 Gut microbiome composition (summer); CESC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.7 -0.38 1.28e-10 Electroencephalogram traits; CESC cis rs9467160 0.734 rs10946702 chr6:24462672 A/G cg20631270 chr6:24437470 GPLD1 -0.44 -5.49 -0.32 9.63e-8 Liver enzyme levels; CESC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg06634786 chr22:41940651 POLR3H -0.7 -7.4 -0.41 1.85e-12 Vitiligo; CESC trans rs1437396 0.657 rs3111404 chr2:55593010 T/A cg07921503 chr7:2445843 CHST12 -0.24 -6.19 -0.36 2.29e-9 Alcohol dependence; CESC cis rs17826219 0.636 rs8080829 chr17:29058730 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Body mass index; CESC cis rs7385804 0.761 rs504141 chr7:100309125 G/A cg20848291 chr7:100343083 ZAN 0.48 6.46 0.37 5.08e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs11077998 0.844 rs8064433 chr17:80501046 A/T cg10255544 chr17:80519551 FOXK2 0.54 8.77 0.47 2.16e-16 Reticulocyte fraction of red cells; CESC cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10751667 0.666 rs7396509 chr11:956761 G/A cg01483505 chr11:975446 AP2A2 0.37 5.05 0.3 8.3e-7 Alzheimer's disease (late onset); CESC cis rs472402 0.623 rs8192133 chr5:6636645 A/G cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.46 -6.13 -0.35 3.2e-9 Response to amphetamines; CESC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg23982607 chr1:1823379 GNB1 -0.75 -11.94 -0.59 1.41e-26 Body mass index; CESC cis rs10504229 0.679 rs16921676 chr8:58052386 G/T cg24829409 chr8:58192753 C8orf71 -0.51 -6.16 -0.35 2.75e-9 Developmental language disorder (linguistic errors); CESC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg24399712 chr22:39784796 NA -0.79 -11.26 -0.57 2.67e-24 Intelligence (multi-trait analysis); CESC cis rs2439831 0.867 rs2614811 chr15:43913487 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.67 8.22 0.45 9.07e-15 Lung cancer in ever smokers; CESC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2921036 0.529 rs2979192 chr8:8338147 C/T cg06636001 chr8:8085503 FLJ10661 0.49 6.09 0.35 3.94e-9 Neuroticism; CESC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg06873352 chr17:61820015 STRADA 0.72 12.71 0.62 3.11e-29 Prudent dietary pattern; CESC cis rs9486719 1.000 rs2472884 chr6:96863965 C/T cg06623918 chr6:96969491 KIAA0776 0.82 8.4 0.46 2.72e-15 Migraine;Coronary artery disease; CESC cis rs2197308 0.659 rs11181327 chr12:37903171 C/T cg26384229 chr12:38710491 ALG10B -0.54 -7.66 -0.43 3.57e-13 Morning vs. evening chronotype; CESC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.52 0.32 7.89e-8 Electroencephalogram traits; CESC cis rs6500602 0.673 rs1861652 chr16:4505331 C/T cg08645402 chr16:4508243 NA 0.49 7.27 0.41 3.98e-12 Schizophrenia; CESC cis rs72634258 0.945 rs225132 chr1:8095500 A/C cg00042356 chr1:8021962 PARK7 0.53 6.06 0.35 4.64e-9 Inflammatory bowel disease; CESC cis rs6546550 0.935 rs6747542 chr2:70106832 T/C cg02498382 chr2:70120550 SNRNP27 -0.36 -6.23 -0.36 1.86e-9 Prevalent atrial fibrillation; CESC cis rs72945132 0.882 rs7129843 chr11:70180381 G/A cg14191688 chr11:70257035 CTTN 0.42 5.38 0.31 1.61e-7 Coronary artery disease; CESC cis rs870825 0.616 rs7660939 chr4:185640792 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs3733585 0.673 rs4447861 chr4:9953940 C/T cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg12386194 chr3:101231763 SENP7 0.44 5.5 0.32 9.14e-8 Colorectal cancer; CESC cis rs4243830 0.850 rs7540913 chr1:6581877 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.78 -8.68 -0.47 4.15e-16 Body mass index; CESC cis rs9467711 0.606 rs9366656 chr6:26434630 T/C cg14345882 chr6:26364793 BTN3A2 0.61 5.84 0.34 1.56e-8 Autism spectrum disorder or schizophrenia; CESC cis rs2657888 0.965 rs2657905 chr12:56935402 T/A cg23002907 chr12:56915593 RBMS2 0.39 5.15 0.3 5.11e-7 Adiponectin levels; CESC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg24829409 chr8:58192753 C8orf71 -0.62 -8.39 -0.46 3.01e-15 Developmental language disorder (linguistic errors); CESC cis rs28374715 0.532 rs1899 chr15:41689232 C/T cg18705301 chr15:41695430 NDUFAF1 -1.03 -16.22 -0.71 1.51e-41 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09356014 chr16:87380193 FBXO31 0.53 7.01 0.4 1.92e-11 Fibrinogen levels; CESC cis rs1559088 0.847 rs2287680 chr19:33608566 A/G cg27124370 chr19:33622961 WDR88 -0.49 -6.49 -0.37 4.22e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4555082 0.874 rs1882846 chr14:105717448 G/C cg27165867 chr14:105738592 BRF1 -0.5 -5.46 -0.32 1.09e-7 Mean platelet volume;Platelet distribution width; CESC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg22800045 chr5:56110881 MAP3K1 0.49 5.83 0.34 1.63e-8 Coronary artery disease; CESC cis rs6964587 1.000 rs6956431 chr7:91750016 T/C cg17063962 chr7:91808500 NA 0.57 7.87 0.44 9.34e-14 Breast cancer; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg13908518 chr1:104096517 RNPC3;AMY2B 0.38 6.35 0.36 9.12e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11264213 0.786 rs72659695 chr1:36311143 T/G cg27506609 chr1:36549197 TEKT2 0.65 5.49 0.32 9.31e-8 Schizophrenia; CESC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg14893161 chr1:205819251 PM20D1 0.51 7.67 0.43 3.23e-13 Menarche (age at onset); CESC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg03188948 chr7:1209495 NA 0.73 7.05 0.4 1.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11098499 0.863 rs1480940 chr4:120457682 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.7 0.51 3e-19 Corneal astigmatism; CESC cis rs258892 0.895 rs13182583 chr5:72051575 C/T cg21869765 chr5:72125136 TNPO1 -0.4 -5.26 -0.31 2.97e-7 Small cell lung carcinoma; CESC trans rs61931739 0.500 rs11053278 chr12:34555955 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.74e-12 Morning vs. evening chronotype; CESC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg06505273 chr16:24850292 NA 0.53 6.51 0.37 3.7e-10 Intelligence (multi-trait analysis); CESC cis rs10882165 0.547 rs10882179 chr10:94952199 C/T cg00992348 chr10:94926053 NA -0.31 -5.39 -0.31 1.57e-7 Refractive error; CESC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg07936489 chr17:37558343 FBXL20 0.73 9.81 0.52 1.43e-19 Glomerular filtration rate (creatinine); CESC cis rs920590 0.684 rs3899017 chr8:19669198 A/T cg03894339 chr8:19674705 INTS10 0.67 7.56 0.42 6.62e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs3825932 0.961 rs10400877 chr15:79234378 A/T cg25744700 chr15:79237217 CTSH 0.48 6.52 0.37 3.62e-10 Type 1 diabetes; CESC cis rs1953600 0.818 rs2152546 chr10:81906384 G/T cg04850286 chr10:81895943 PLAC9 -0.3 -5.15 -0.3 5.01e-7 Sarcoidosis; CESC cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs3540 0.597 rs3743409 chr15:91045539 T/A cg22089800 chr15:90895588 ZNF774 -0.65 -8.98 -0.48 5.06e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs7208859 0.673 rs9915139 chr17:29158515 A/G cg19761014 chr17:28927070 LRRC37B2 0.78 6.29 0.36 1.31e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3126085 0.935 rs11204951 chr1:152224404 A/G cg03465714 chr1:152285911 FLG -0.46 -5.75 -0.33 2.47e-8 Atopic dermatitis; CESC cis rs72945132 0.882 rs17160039 chr11:70145489 A/G cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs12541635 0.966 rs4734128 chr8:107026913 G/A cg10147462 chr8:107024639 NA 0.41 5.77 0.33 2.26e-8 Age of smoking initiation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18439323 chr14:23755769 HOMEZ -0.57 -7.07 -0.4 1.38e-11 Gut microbiome composition (summer); CESC cis rs7568458 0.684 rs6731700 chr2:85760991 C/G cg02493740 chr2:85810744 VAMP5 -0.57 -8.29 -0.45 5.86e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs2273669 0.667 rs17070139 chr6:109358345 C/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.06 -0.35 4.74e-9 Prostate cancer; CESC trans rs1814175 0.817 rs1818890 chr11:49856882 T/C cg15704280 chr7:45808275 SEPT13 -1.02 -19.98 -0.78 8.73e-55 Height; CESC trans rs61931739 0.500 rs7488438 chr12:34531359 G/T cg26384229 chr12:38710491 ALG10B 0.73 10.87 0.56 5.18e-23 Morning vs. evening chronotype; CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg06877462 chr1:205807181 PM20D1 0.46 7.03 0.4 1.76e-11 Menarche (age at onset); CESC cis rs9308731 0.591 rs13398360 chr2:111937940 C/T cg04202892 chr2:111875749 ACOXL 0.37 5.18 0.3 4.34e-7 Chronic lymphocytic leukemia; CESC cis rs818427 0.548 rs373059 chr5:112188437 G/A cg07820702 chr5:112228657 REEP5 0.4 5.3 0.31 2.46e-7 Total body bone mineral density; CESC cis rs2204008 0.557 rs11520191 chr12:38197057 T/A cg26384229 chr12:38710491 ALG10B 0.71 10.3 0.53 3.96e-21 Bladder cancer; CESC cis rs7666738 0.830 rs10001479 chr4:98918764 A/G cg05340658 chr4:99064831 C4orf37 -0.66 -8.88 -0.48 1.01e-16 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg11494091 chr17:61959527 GH2 0.72 12.16 0.6 2.58e-27 Prudent dietary pattern; CESC cis rs73001065 0.792 rs17216525 chr19:19662220 C/T cg03709012 chr19:19516395 GATAD2A 0.99 6.13 0.35 3.1e-9 LDL cholesterol; CESC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg25251562 chr2:3704773 ALLC -0.63 -6.57 -0.37 2.73e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs922182 0.607 rs8030264 chr15:64271496 C/T cg24729988 chr15:64271149 DAPK2 -0.48 -6.84 -0.39 5.34e-11 Blood protein levels; CESC cis rs9325144 0.560 rs10785562 chr12:38637419 A/C cg26384229 chr12:38710491 ALG10B -0.58 -8.27 -0.45 6.69e-15 Morning vs. evening chronotype; CESC cis rs9788682 0.748 rs667282 chr15:78863472 T/C cg24631222 chr15:78858424 CHRNA5 0.8 10.3 0.53 3.7e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg00784671 chr22:46762841 CELSR1 -0.49 -5.67 -0.33 3.76e-8 LDL cholesterol;Cholesterol, total; CESC cis rs478304 0.934 rs1193496 chr11:65537556 C/T cg08755490 chr11:65554678 OVOL1 -0.46 -6.06 -0.35 4.6e-9 Acne (severe); CESC cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg11764359 chr7:65958608 NA -0.81 -8.99 -0.48 4.92e-17 Aortic root size; CESC cis rs11864453 0.826 rs12708928 chr16:72137227 C/A cg16558253 chr16:72132732 DHX38 -0.6 -9.59 -0.51 6.97e-19 Fibrinogen levels; CESC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg15445000 chr17:37608096 MED1 -0.4 -6.48 -0.37 4.55e-10 Glomerular filtration rate (creatinine); CESC cis rs7312774 0.618 rs2888892 chr12:107328071 C/T cg16260113 chr12:107380972 MTERFD3 0.84 7.16 0.4 8.13e-12 Severe influenza A (H1N1) infection; CESC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs61776719 0.520 rs17465651 chr1:38418496 C/T cg18451016 chr1:38461880 NA 0.42 6.24 0.36 1.68e-9 Coronary artery disease; CESC cis rs2760061 0.626 rs672977 chr1:228120288 A/C cg01973587 chr1:228161476 NA 0.38 5.93 0.34 9.18e-9 Diastolic blood pressure; CESC cis rs2645694 0.626 rs2645704 chr4:77830805 T/C cg10057126 chr4:77819792 ANKRD56 0.6 8.56 0.47 9.47e-16 Emphysema distribution in smoking; CESC cis rs4629180 0.675 rs10183203 chr2:102095080 C/T cg01388757 chr2:102091195 RFX8 0.31 5.07 0.3 7.59e-7 Chronic rhinosinusitis with nasal polyps; CESC trans rs2391518 0.639 rs2968998 chr4:130784655 A/G cg24601559 chr2:43328536 NA 0.35 6.1 0.35 3.83e-9 Body mass index; CESC cis rs12477438 1.000 rs12053372 chr2:99810055 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -8.36 -0.46 3.54e-15 Chronic sinus infection; CESC cis rs3793683 0.520 rs12769959 chr10:134579026 A/C cg27286337 chr10:134555280 INPP5A 0.66 7.7 0.43 2.68e-13 Migraine; CESC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.5 0.37 3.97e-10 Bipolar disorder; CESC cis rs796364 0.806 rs188102 chr2:200903189 T/A cg23649088 chr2:200775458 C2orf69 -0.57 -5.24 -0.31 3.23e-7 Schizophrenia; CESC cis rs4073582 0.595 rs10896104 chr11:66001869 C/T cg14036092 chr11:66035641 RAB1B 0.55 7.65 0.43 3.82e-13 Gout; CESC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg18479299 chr3:125709523 NA -0.47 -5.05 -0.3 8.2e-7 Blood pressure (smoking interaction); CESC trans rs61931739 1.000 rs12298806 chr12:34036528 C/G cg26384229 chr12:38710491 ALG10B -0.46 -6.16 -0.35 2.75e-9 Morning vs. evening chronotype; CESC trans rs3942852 0.545 rs7395231 chr11:48091689 T/C cg03929089 chr4:120376271 NA -0.64 -7.91 -0.44 6.85e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs7582720 1.000 rs79539678 chr2:203740938 G/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs9948 0.655 rs6751132 chr2:97405866 T/C cg01990225 chr2:97406019 LMAN2L -0.88 -7.35 -0.41 2.53e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg18876405 chr7:65276391 NA 0.51 6.74 0.38 9.86e-11 Aortic root size; CESC cis rs2732480 0.557 rs923397 chr12:48720392 G/A cg04545296 chr12:48745243 ZNF641 0.36 6.27 0.36 1.49e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2033711 0.654 rs734380 chr19:58898963 A/C cg11952622 chr19:58962976 ZNF324B 0.39 5.3 0.31 2.49e-7 Uric acid clearance; CESC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg08736216 chr1:53307985 ZYG11A -0.41 -6.68 -0.38 1.42e-10 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00524296 chr16:88928681 PABPN1L -0.56 -6.99 -0.39 2.2e-11 Gut microbiome composition (summer); CESC trans rs3780486 0.874 rs10813955 chr9:33141791 C/T cg20290983 chr6:43655470 MRPS18A 0.98 17.7 0.74 8.37e-47 IgG glycosylation; CESC cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg17724175 chr1:150552817 MCL1 -0.32 -5.21 -0.3 3.77e-7 Tonsillectomy; CESC cis rs7818688 0.697 rs77805255 chr8:95983566 G/A cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.81 0.34 1.81e-8 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04565464 chr8:145669602 NFKBIL2 0.57 6.45 0.37 5.34e-10 Gut microbiome composition (summer); CESC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.26 -0.49 7.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg21285383 chr16:89894308 SPIRE2 0.3 5.4 0.31 1.5e-7 Vitiligo; CESC trans rs3780486 0.846 rs10813950 chr9:33127640 A/G cg20290983 chr6:43655470 MRPS18A -0.92 -15.5 -0.69 5.15e-39 IgG glycosylation; CESC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg19592336 chr6:28129416 ZNF389 0.47 6.96 0.39 2.68e-11 Cardiac Troponin-T levels; CESC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg10691866 chr7:65817282 TPST1 -0.34 -5.47 -0.32 1.06e-7 Aortic root size; CESC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.41e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9916302 0.904 rs6503503 chr17:37514373 G/A cg15445000 chr17:37608096 MED1 -0.41 -6.6 -0.38 2.18e-10 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06756931 chr17:78820893 RPTOR -0.53 -6.06 -0.35 4.78e-9 Gut microbiome composition (summer); CESC trans rs71636778 0.509 rs17162311 chr1:27174966 C/T cg21878188 chr8:67089887 CRH 0.73 6.05 0.35 5.05e-9 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs6545883 0.929 rs778154 chr2:61646631 T/C cg15711740 chr2:61764176 XPO1 0.39 5.04 0.3 8.79e-7 Tuberculosis; CESC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg22549504 chr19:17448937 GTPBP3 0.48 5.4 0.31 1.52e-7 Systemic lupus erythematosus; CESC cis rs9640161 0.659 rs77354576 chr7:150013300 A/C cg21361702 chr7:150065534 REPIN1 0.51 5.89 0.34 1.19e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs644799 1.000 rs481630 chr11:95582447 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.62 0.38 1.95e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs372883 0.600 rs1236460 chr21:30615513 G/A cg24692254 chr21:30365293 RNF160 -0.6 -7.74 -0.43 2.16e-13 Pancreatic cancer; CESC cis rs6541297 0.887 rs6541295 chr1:230281698 A/G cg20703242 chr1:230279135 GALNT2 0.75 8.08 0.44 2.34e-14 Coronary artery disease; CESC cis rs977987 0.806 rs11641587 chr16:75464419 G/T cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC cis rs8060686 0.641 rs11075665 chr16:68070774 C/T cg26727032 chr16:67993705 SLC12A4 -0.55 -6.23 -0.36 1.81e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs3806843 1.000 rs6579987 chr5:140183659 T/C cg26395211 chr5:140044315 WDR55 -0.42 -5.33 -0.31 2.07e-7 Depressive symptoms (multi-trait analysis); CESC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg10053473 chr17:62856997 LRRC37A3 -0.72 -7.62 -0.42 4.44e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7408868 1.000 rs7254269 chr19:15277429 A/T cg14696996 chr19:15285081 NOTCH3 -1.08 -11.77 -0.59 5.18e-26 Pulse pressure; CESC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg27121462 chr16:89883253 FANCA 0.8 11.85 0.59 2.9e-26 Vitiligo; CESC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.58 7.37 0.41 2.2e-12 Prudent dietary pattern; CESC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg13012494 chr21:47604986 C21orf56 -0.44 -5.82 -0.34 1.72e-8 Testicular germ cell tumor; CESC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg24060327 chr5:131705240 SLC22A5 -0.4 -5.12 -0.3 5.81e-7 Breast cancer; CESC cis rs2637266 1.000 rs7475638 chr10:78358586 G/T cg18941641 chr10:78392320 NA -0.41 -7.58 -0.42 5.8e-13 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14058584 chr2:130939451 SMPD4;FAM128B 0.55 6.12 0.35 3.43e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09067967 chr4:39529342 UGDH 0.56 6.99 0.39 2.17e-11 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10494282 chr1:44440945 ATP6V0B -0.44 -6.07 -0.35 4.42e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.66 0.61 4.8e-29 Colonoscopy-negative controls vs population controls; CESC cis rs10927875 0.691 rs1048261 chr1:16340951 A/T cg22431228 chr1:16359049 CLCNKA -0.48 -7.88 -0.44 8.75e-14 Dilated cardiomyopathy; CESC cis rs72781680 0.898 rs72782113 chr2:24024952 G/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs72781680 1.000 rs72781643 chr2:24208746 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.58 0.32 5.96e-8 Lymphocyte counts; CESC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC trans rs10751667 1.000 rs6597972 chr11:928402 C/T cg27162705 chr10:114713024 TCF7L2 -0.4 -6.1 -0.35 3.66e-9 Alzheimer's disease (late onset); CESC cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -8.09 -0.45 2.1e-14 Personality dimensions; CESC cis rs7917772 0.503 rs10748825 chr10:104293609 A/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.17 0.3 4.66e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs11997175 0.624 rs6996590 chr8:33680486 A/G ch.8.33884649F chr8:33765107 NA 0.58 7.4 0.41 1.85e-12 Body mass index; CESC cis rs7546094 1.000 rs6666579 chr1:113132393 A/G cg22162597 chr1:113214053 CAPZA1 0.36 5.6 0.33 5.45e-8 Platelet distribution width; CESC cis rs7945705 0.837 rs10769981 chr11:9024460 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.46 7.56 0.42 6.62e-13 Hemoglobin concentration; CESC cis rs4629180 0.675 rs6707298 chr2:102089738 A/G cg04415270 chr2:102091202 RFX8 0.32 5.61 0.33 5.01e-8 Chronic rhinosinusitis with nasal polyps; CESC cis rs7851660 0.870 rs1867278 chr9:100615949 C/A cg13688889 chr9:100608707 NA -0.69 -10.57 -0.54 4.92e-22 Strep throat; CESC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.67 6.9 0.39 3.79e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs59918340 0.523 rs4961255 chr8:142208248 T/C cg23750338 chr8:142222470 SLC45A4 0.46 6.52 0.37 3.44e-10 Immature fraction of reticulocytes; CESC cis rs2625529 0.617 rs11633167 chr15:72179178 C/A cg16672083 chr15:72433130 SENP8 0.37 5.47 0.32 1.06e-7 Red blood cell count; CESC cis rs1801251 1.000 rs6745879 chr2:233590007 A/G cg08000102 chr2:233561755 GIGYF2 0.69 9.56 0.51 8.52e-19 Coronary artery disease; CESC cis rs6540556 0.723 rs3765240 chr1:209918151 G/A cg23920097 chr1:209922102 NA -0.41 -6.03 -0.35 5.56e-9 Red blood cell count; CESC cis rs10883723 0.810 rs10786671 chr10:104271303 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.76e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19818298 chr14:21905552 CHD8 0.39 6.2 0.36 2.1e-9 Gambling; CESC cis rs9486719 1.000 rs13207333 chr6:96882254 T/C cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.78 0.38 7.75e-11 Bipolar disorder; CESC trans rs4843747 0.671 rs4072871 chr16:88106614 C/T cg26811252 chr16:29126840 RRN3P2 0.68 9.51 0.5 1.18e-18 Menopause (age at onset); CESC cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg19717773 chr7:2847554 GNA12 -0.52 -8.16 -0.45 1.32e-14 Height; CESC cis rs1568889 0.838 rs11030187 chr11:28044391 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.73 0.64 9.4e-33 Bipolar disorder; CESC cis rs4722166 0.695 rs7793125 chr7:22809160 A/G cg05265849 chr7:22767390 IL6 0.44 6.2 0.36 2.19e-9 Lung cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13904199 chr9:86594091 HNRNPK 0.47 6.04 0.35 5.17e-9 Gut microbiota (bacterial taxa); CESC cis rs6831352 0.877 rs29001183 chr4:100056539 C/T cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg00730857 chr4:1994281 WHSC2 0.4 5.07 0.3 7.45e-7 Longevity; CESC trans rs9936075 0.519 rs13334398 chr16:7411518 G/A cg24715815 chr2:183642235 DNAJC10 0.55 6.49 0.37 4.19e-10 Platelet-derived growth factor BB levels; CESC cis rs7833790 0.553 rs9693128 chr8:82706128 A/G cg02079420 chr8:82753780 SNX16 0.37 5.36 0.31 1.82e-7 Diastolic blood pressure; CESC cis rs748404 0.697 rs546722 chr15:43580819 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.59 7.77 0.43 1.69e-13 Lung cancer; CESC cis rs3092073 0.624 rs3848719 chr20:44596545 G/A cg17986701 chr20:44574422 PCIF1 0.35 5.11 0.3 6.03e-7 Intelligence (multi-trait analysis); CESC cis rs10779751 1.000 rs11121703 chr1:11293792 G/T cg08854313 chr1:11322531 MTOR -0.84 -12.07 -0.6 5.2e-27 Body mass index; CESC cis rs1707322 0.964 rs7512395 chr1:46361177 G/A cg03146154 chr1:46216737 IPP 0.78 10.75 0.55 1.29e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07706515 chr7:4830907 KIAA0415 -0.57 -6.3 -0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs13102973 0.932 rs11099305 chr4:135895569 C/G cg14419869 chr4:135874104 NA 0.34 5.33 0.31 2.13e-7 Subjective well-being; CESC cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg13902645 chr11:5959945 NA -0.51 -6.02 -0.35 5.95e-9 DNA methylation (variation); CESC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg08888203 chr3:10149979 C3orf24 0.46 5.84 0.34 1.5e-8 Alzheimer's disease; CESC cis rs7264396 0.790 rs4519606 chr20:34324648 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.56 7.19 0.4 6.71e-12 Total cholesterol levels; CESC cis rs11683229 0.704 rs4671453 chr2:63102012 G/A cg17519650 chr2:63277830 OTX1 -0.68 -5.46 -0.32 1.11e-7 Protein quantitative trait loci; CESC cis rs561341 0.739 rs9906455 chr17:30215669 G/A cg13647721 chr17:30228624 UTP6 -0.76 -9.32 -0.5 4.59e-18 Hip circumference adjusted for BMI; CESC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg22800045 chr5:56110881 MAP3K1 -0.61 -7.65 -0.43 3.63e-13 Initial pursuit acceleration; CESC cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg22823121 chr1:150693482 HORMAD1 -0.36 -5.3 -0.31 2.47e-7 Tonsillectomy; CESC cis rs8017423 0.586 rs2896134 chr14:90831293 G/A cg14092571 chr14:90743983 NA 0.43 6.42 0.37 6.16e-10 Mortality in heart failure; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg22085380 chr3:120174428 NA 0.45 6.1 0.35 3.71e-9 Thyroid stimulating hormone; CESC cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg18180107 chr4:99064573 C4orf37 0.4 5.12 0.3 5.82e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8141529 0.732 rs2269577 chr22:29196757 G/C cg15103426 chr22:29168792 CCDC117 0.7 9.94 0.52 5.59e-20 Lymphocyte counts; CESC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg05368731 chr17:41323189 NBR1 0.77 10.75 0.55 1.27e-22 Menopause (age at onset); CESC cis rs9303401 0.614 rs3087762 chr17:56568680 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.0 12.06 0.6 5.33e-27 Cognitive test performance; CESC cis rs2576037 0.796 rs6507718 chr18:44581284 G/C cg19077165 chr18:44547161 KATNAL2 0.51 7.13 0.4 9.52e-12 Personality dimensions; CESC cis rs11645898 0.748 rs11641424 chr16:72066879 C/T cg14768367 chr16:72042858 DHODH -0.84 -6.92 -0.39 3.43e-11 Blood protein levels; CESC cis rs4253772 0.530 rs8140573 chr22:46800363 G/C cg00784671 chr22:46762841 CELSR1 -0.48 -5.1 -0.3 6.39e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6669072 0.647 rs2954561 chr1:91240853 G/A cg08895590 chr1:91227319 NA -0.33 -5.73 -0.33 2.75e-8 Cognitive function; CESC trans rs5756813 0.700 rs1894525 chr22:38186400 G/A cg19894588 chr14:64061835 NA -0.63 -7.98 -0.44 4.47e-14 Optic cup area;Vertical cup-disc ratio; CESC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg08859206 chr1:53392774 SCP2 0.54 7.15 0.4 8.22e-12 Monocyte count; CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg22741997 chr17:6900356 ALOX12 0.43 6.86 0.39 4.74e-11 Tonsillectomy; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg02260482 chr12:104359603 TDG 0.46 6.07 0.35 4.37e-9 Bronchopulmonary dysplasia; CESC cis rs9815354 1.000 rs17063584 chr3:41861463 A/G cg03022575 chr3:42003672 ULK4 0.47 5.22 0.31 3.69e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg07936489 chr17:37558343 FBXL20 -0.74 -10.22 -0.53 6.77e-21 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21587637 chr13:25861355 MTMR6 0.62 6.78 0.38 7.9e-11 Gut microbiome composition (summer); CESC cis rs2797685 1.000 rs707467 chr1:7861684 A/C cg04725166 chr1:7887271 PER3 -0.44 -5.99 -0.35 6.84e-9 Crohn's disease; CESC cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg17971929 chr21:40555470 PSMG1 0.58 7.57 0.42 6.1e-13 Cognitive function; CESC cis rs72781680 0.848 rs55725028 chr2:23966447 A/G cg20701182 chr2:24300061 SF3B14 0.76 6.71 0.38 1.15e-10 Lymphocyte counts; CESC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC cis rs4474465 0.850 rs4285892 chr11:78243134 C/A cg27205649 chr11:78285834 NARS2 0.44 5.34 0.31 1.96e-7 Alzheimer's disease (survival time); CESC cis rs920590 0.721 rs61180388 chr8:19670214 G/C cg01411142 chr8:19674711 INTS10 0.55 6.02 0.35 5.68e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg08859206 chr1:53392774 SCP2 0.56 7.29 0.41 3.54e-12 Monocyte count; CESC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg26039829 chr8:22132926 PIWIL2 0.38 5.89 0.34 1.19e-8 Hypertriglyceridemia; CESC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg18016565 chr1:150552671 MCL1 0.34 5.25 0.31 3.08e-7 Tonsillectomy; CESC cis rs3857067 0.509 rs11729256 chr4:95027272 A/G cg11021082 chr4:95130006 SMARCAD1 0.42 5.31 0.31 2.36e-7 QT interval; CESC cis rs1577917 0.958 rs10944147 chr6:86550786 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.14 -0.35 2.93e-9 Response to antipsychotic treatment; CESC cis rs6540556 0.634 rs11485195 chr1:209891738 T/C cg05527609 chr1:210001259 C1orf107 -0.67 -7.35 -0.41 2.43e-12 Red blood cell count; CESC cis rs3020736 0.500 rs9620026 chr22:42498578 C/T cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC cis rs11249608 0.548 rs7709054 chr5:178462757 C/T cg01312482 chr5:178451176 ZNF879 -0.45 -6.05 -0.35 4.95e-9 Pubertal anthropometrics; CESC cis rs12950390 0.853 rs11079791 chr17:45859099 C/T cg00777063 chr17:45855553 NA -0.38 -5.78 -0.33 2.08e-8 IgG glycosylation; CESC trans rs10028773 0.556 rs4473640 chr4:120260437 G/A cg25214090 chr10:38739885 LOC399744 0.61 8.64 0.47 5.49e-16 Educational attainment; CESC cis rs826838 0.967 rs7970069 chr12:38810631 T/C cg13010199 chr12:38710504 ALG10B 0.6 8.53 0.46 1.18e-15 Heart rate; CESC trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg06636001 chr8:8085503 FLJ10661 0.52 6.68 0.38 1.41e-10 Retinal vascular caliber; CESC cis rs2730245 1.000 rs6965685 chr7:158726462 C/T cg24397884 chr7:158709396 WDR60 0.85 12.94 0.62 5.12e-30 Height; CESC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg18337363 chr3:52569053 NT5DC2 0.34 6.4 0.37 7e-10 Electroencephalogram traits; CESC cis rs2760061 0.583 rs708124 chr1:228220771 A/T cg02753203 chr1:228287806 NA 0.83 13.13 0.63 1.09e-30 Diastolic blood pressure; CESC cis rs6087990 0.842 rs4911253 chr20:31352585 A/G cg13636640 chr20:31349939 DNMT3B 0.79 12.8 0.62 1.58e-29 Ulcerative colitis; CESC cis rs1055129 0.560 rs56248937 chr17:73915153 T/A cg02678768 chr17:74002944 EVPL 0.42 5.91 0.34 1.02e-8 White matter hyperintensity burden; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21483906 chr3:33758870 CLASP2 0.54 6.09 0.35 3.94e-9 Gut microbiome composition (summer); CESC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg07747251 chr5:1868357 NA 0.32 5.39 0.31 1.54e-7 Cardiovascular disease risk factors; CESC cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg01475377 chr6:109611718 NA -0.49 -8.21 -0.45 9.56e-15 Reticulocyte fraction of red cells; CESC cis rs6598955 0.670 rs4659366 chr1:26542572 G/A cg00852783 chr1:26633632 UBXN11 0.4 5.83 0.34 1.57e-8 Obesity-related traits; CESC cis rs763014 0.931 rs3752567 chr16:628130 A/G cg00802000 chr16:706648 WDR90 -0.42 -6.22 -0.36 1.96e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22254299 chr17:77772001 CBX8 0.6 6.57 0.37 2.65e-10 Gut microbiome composition (summer); CESC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.63 0.51 5.12e-19 Platelet count; CESC cis rs2932538 0.922 rs6663922 chr1:113095948 T/C cg22162597 chr1:113214053 CAPZA1 0.47 6.21 0.36 2.05e-9 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg17971929 chr21:40555470 PSMG1 -0.86 -12.83 -0.62 1.24e-29 Cognitive function; CESC cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg17366294 chr4:99064904 C4orf37 0.57 7.73 0.43 2.3e-13 Colonoscopy-negative controls vs population controls; CESC cis rs56235845 0.694 rs11949401 chr5:176765989 A/G cg17509989 chr5:176798049 RGS14 0.5 6.27 0.36 1.47e-9 Hemoglobin concentration;Hematocrit; CESC cis rs12618769 0.652 rs76525766 chr2:99221088 A/G cg10123293 chr2:99228465 UNC50 0.4 5.32 0.31 2.2e-7 Bipolar disorder; CESC cis rs2243480 0.808 rs12698508 chr7:65411958 A/T cg13147721 chr7:65941812 NA -0.88 -8.15 -0.45 1.5e-14 Diabetic kidney disease; CESC cis rs8064299 0.655 rs895691 chr17:72766300 G/T cg25054828 chr17:72772726 NAT9;TMEM104 0.48 6.51 0.37 3.79e-10 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04198107 chr10:125852011 NA -0.63 -7.28 -0.41 3.86e-12 Gut microbiome composition (summer); CESC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg17724175 chr1:150552817 MCL1 0.38 5.9 0.34 1.11e-8 Melanoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10729317 chr20:2821390 FAM113A;VPS16 0.6 7.51 0.42 8.99e-13 Gut microbiome composition (summer); CESC cis rs909674 0.865 rs5757683 chr22:39850174 G/A cg24399712 chr22:39784796 NA -0.81 -10.59 -0.55 4.37e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7091068 0.616 rs7084701 chr10:95482249 A/G cg20715218 chr10:95462985 C10orf4 0.52 5.37 0.31 1.69e-7 Urinary tract infection frequency; CESC cis rs2404602 0.536 rs17364330 chr15:76765385 A/T cg22467129 chr15:76604101 ETFA -0.4 -6.27 -0.36 1.48e-9 Blood metabolite levels; CESC cis rs2425143 1.000 rs117010355 chr20:34343442 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.44 0.32 1.2e-7 Blood protein levels; CESC cis rs938554 0.513 rs3775947 chr4:9995240 C/T cg11266682 chr4:10021025 SLC2A9 0.5 7.25 0.41 4.69e-12 Blood metabolite levels; CESC trans rs2018683 0.707 rs7799357 chr7:28970118 A/G cg19402173 chr7:128379420 CALU -0.53 -7.1 -0.4 1.13e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs2228479 0.867 rs62052189 chr16:89975555 G/C cg06558623 chr16:89946397 TCF25 0.9 7.89 0.44 7.95e-14 Skin colour saturation; CESC cis rs4722166 0.630 rs4722168 chr7:22779002 G/A cg26061582 chr7:22766209 IL6 0.51 5.55 0.32 6.82e-8 Lung cancer; CESC cis rs4374383 0.532 rs4525701 chr2:112787827 A/G cg07905836 chr2:113190072 RGPD8;RGPD5 0.56 5.83 0.34 1.59e-8 Hepatitis C induced liver fibrosis; CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg26354017 chr1:205819088 PM20D1 0.91 15.59 0.69 2.45e-39 Menarche (age at onset); CESC cis rs4330281 0.715 rs7427588 chr3:17806424 A/G cg20981856 chr3:17787350 NA 0.37 5.17 0.3 4.61e-7 Schizophrenia; CESC cis rs11098499 0.739 rs9884728 chr4:120127079 C/T cg09307838 chr4:120376055 NA -0.67 -8.34 -0.46 4e-15 Corneal astigmatism; CESC cis rs3733585 0.806 rs11723382 chr4:9954660 T/C cg11266682 chr4:10021025 SLC2A9 -0.61 -12.75 -0.62 2.35e-29 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4555082 1.000 rs7146683 chr14:105759385 A/G cg27165867 chr14:105738592 BRF1 -0.47 -5.52 -0.32 7.94e-8 Mean platelet volume;Platelet distribution width; CESC cis rs1387259 0.929 rs2956703 chr12:48670294 C/T cg24011408 chr12:48396354 COL2A1 0.43 6.07 0.35 4.46e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs9309473 0.687 rs10165862 chr2:73610743 C/T cg20560298 chr2:73613845 ALMS1 -0.45 -6.4 -0.37 7.04e-10 Metabolite levels; CESC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.66 -7.37 -0.41 2.12e-12 Gut microbiome composition (summer); CESC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg16405210 chr4:1374714 KIAA1530 -0.6 -8.28 -0.45 6.07e-15 Longevity; CESC cis rs2276314 1.000 rs58054756 chr18:33554053 G/C cg05985134 chr18:33552581 C18orf21 0.65 7.57 0.42 6.14e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs61996546 0.622 rs61998698 chr15:26868306 G/C cg14859324 chr15:26874363 GABRB3 -0.38 -5.27 -0.31 2.81e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg22920501 chr2:26401640 FAM59B -0.7 -8.35 -0.46 3.85e-15 Gut microbiome composition (summer); CESC cis rs6580649 0.941 rs7310579 chr12:48427523 G/A cg05342945 chr12:48394962 COL2A1 0.53 6.07 0.35 4.33e-9 Lung cancer; CESC cis rs11696501 0.688 rs6073848 chr20:44298550 G/A cg11783356 chr20:44313418 WFDC10B -0.34 -5.3 -0.31 2.4e-7 Brain structure; CESC cis rs9487051 0.676 rs7773775 chr6:109600339 T/C cg01475377 chr6:109611718 NA -0.43 -6.82 -0.39 6.19e-11 Reticulocyte fraction of red cells; CESC cis rs12042107 0.740 rs2166171 chr1:91208451 T/C cg13456504 chr1:91191583 NA -0.34 -5.79 -0.34 1.97e-8 Educational attainment; CESC cis rs4481887 0.893 rs1934543 chr1:248505602 C/G cg00666640 chr1:248458726 OR2T12 0.35 6.04 0.35 5.14e-9 Common traits (Other); CESC cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg02297831 chr4:17616191 MED28 0.61 7.82 0.43 1.23e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6598955 0.671 rs17163868 chr1:26648381 A/G cg19743891 chr1:26644573 UBXN11;CD52 -0.36 -5.27 -0.31 2.84e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25166340 chr7:39605883 C7orf36 0.58 6.85 0.39 5e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16235531 chr5:66459345 MAST4 -0.57 -6.56 -0.37 2.77e-10 Gut microbiome composition (summer); CESC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg20891558 chr2:74357851 NA 0.75 9.91 0.52 6.63e-20 Gestational age at birth (maternal effect); CESC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.62 -8.04 -0.44 2.94e-14 Tonsillectomy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12780433 chr3:159481918 SCHIP1 -0.44 -6.26 -0.36 1.58e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1348850 0.567 rs880897 chr2:178532503 C/T cg22681709 chr2:178499509 PDE11A -0.49 -7.27 -0.41 4.12e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6754311 0.731 rs7579771 chr2:136580260 T/A cg07169764 chr2:136633963 MCM6 0.64 7.7 0.43 2.68e-13 Mosquito bite size; CESC trans rs7746199 0.736 rs58616630 chr6:27474715 A/G cg21479132 chr6:26055353 NA 0.84 6.06 0.35 4.64e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs6121246 0.954 rs6058470 chr20:30416827 A/T cg13852791 chr20:30311386 BCL2L1 0.82 8.33 0.46 4.24e-15 Mean corpuscular hemoglobin; CESC cis rs2710642 0.576 rs6545968 chr2:62871184 C/A cg17519650 chr2:63277830 OTX1 0.51 5.98 0.34 7.08e-9 LDL cholesterol levels;LDL cholesterol; CESC cis rs3026101 0.624 rs55970234 chr17:5316765 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.17 0.3 4.63e-7 Body mass index; CESC cis rs7223966 0.655 rs9906882 chr17:61634382 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.47 5.26 0.31 3.03e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg02463440 chr8:22132932 PIWIL2 -0.4 -6.21 -0.36 2.03e-9 Hypertriglyceridemia; CESC cis rs9612 1.000 rs12611034 chr19:44268678 C/T cg08581076 chr19:44259116 C19orf61 0.49 5.76 0.33 2.35e-8 Exhaled nitric oxide output; CESC cis rs6456156 0.792 rs4710178 chr6:167513532 G/A cg07741184 chr6:167504864 NA 0.38 6.89 0.39 4.14e-11 Primary biliary cholangitis; CESC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg15445000 chr17:37608096 MED1 -0.41 -6.73 -0.38 1.03e-10 Glomerular filtration rate (creatinine); CESC cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.15 0.53 1.13e-20 Hip circumference adjusted for BMI; CESC cis rs2439831 0.850 rs558656 chr15:43723514 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.87 10.44 0.54 1.39e-21 Lung cancer in ever smokers; CESC cis rs62432291 0.681 rs425906 chr6:159657575 C/T cg14500486 chr6:159655392 FNDC1 -0.62 -6.34 -0.36 9.83e-10 Joint mobility (Beighton score); CESC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg24578937 chr1:2090814 PRKCZ -0.35 -6.06 -0.35 4.65e-9 Height; CESC cis rs7615952 0.799 rs13315434 chr3:125641394 T/G cg05084668 chr3:125655381 ALG1L -0.45 -5.44 -0.32 1.21e-7 Blood pressure (smoking interaction); CESC cis rs4423214 0.570 rs7118246 chr11:71231124 G/C cg05163923 chr11:71159392 DHCR7 0.74 9.16 0.49 1.44e-17 Vitamin D levels; CESC cis rs10870270 1.000 rs10870271 chr10:133754807 A/G cg17892150 chr10:133769511 PPP2R2D 0.84 12.0 0.59 8.42e-27 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7937682 0.632 rs11214028 chr11:111761149 T/C cg22437258 chr11:111473054 SIK2 -0.5 -5.53 -0.32 7.78e-8 Primary sclerosing cholangitis; CESC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg27535305 chr1:53392650 SCP2 -0.33 -5.47 -0.32 1.03e-7 Monocyte count; CESC cis rs6121246 0.909 rs3203770 chr20:30382315 A/G cg13852791 chr20:30311386 BCL2L1 0.81 8.61 0.47 6.48e-16 Mean corpuscular hemoglobin; CESC cis rs7520050 0.966 rs7540325 chr1:46338217 A/T cg03146154 chr1:46216737 IPP -0.48 -6.22 -0.36 1.98e-9 Red blood cell count;Reticulocyte count; CESC cis rs7100689 0.556 rs10788541 chr10:82016530 T/G cg00277334 chr10:82204260 NA -0.48 -6.1 -0.35 3.69e-9 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27360527 chr16:85722694 GINS2 0.59 6.71 0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg25985355 chr7:65971099 NA 0.31 5.08 0.3 7.18e-7 Aortic root size; CESC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg07507251 chr3:52567010 NT5DC2 0.39 6.87 0.39 4.68e-11 Bipolar disorder; CESC cis rs4268898 0.662 rs55661701 chr2:24400769 A/C cg06627628 chr2:24431161 ITSN2 -0.98 -9.85 -0.52 1.06e-19 Asthma; CESC cis rs854765 1.000 rs854765 chr17:18012730 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.48 -6.25 -0.36 1.61e-9 Total body bone mineral density; CESC cis rs6500602 0.789 rs2404546 chr16:4479734 C/G cg08645402 chr16:4508243 NA 0.43 6.65 0.38 1.67e-10 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21150049 chr12:50677498 LIMA1 -0.5 -6.68 -0.38 1.39e-10 Ulcerative colitis; CESC cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg24829409 chr8:58192753 C8orf71 -0.47 -5.83 -0.34 1.63e-8 Developmental language disorder (linguistic errors); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13823188 chr17:80039244 FASN 0.46 6.41 0.37 6.63e-10 Fibrinogen levels; CESC cis rs4268898 0.931 rs34504814 chr2:24503766 C/T cg08917208 chr2:24149416 ATAD2B 0.46 5.29 0.31 2.59e-7 Asthma; CESC cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg03676636 chr4:99064102 C4orf37 0.36 5.36 0.31 1.78e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.03 -0.4 1.73e-11 Personality dimensions; CESC cis rs3768617 0.528 rs6672093 chr1:183079853 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 13.05 0.63 2.08e-30 Fuchs's corneal dystrophy; CESC cis rs5758659 0.652 rs133330 chr22:42409456 G/A cg04733989 chr22:42467013 NAGA 0.44 5.85 0.34 1.41e-8 Cognitive function; CESC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg25405998 chr7:65216604 CCT6P1 0.47 5.3 0.31 2.38e-7 Aortic root size; CESC cis rs7584330 0.638 rs13429533 chr2:238448712 A/G cg06639874 chr2:238417703 MLPH -0.37 -5.56 -0.32 6.73e-8 Prostate cancer; CESC cis rs4268898 0.931 rs60716082 chr2:24526265 T/A cg08917208 chr2:24149416 ATAD2B 0.47 5.37 0.31 1.73e-7 Asthma; CESC cis rs56804039 1.000 rs56804039 chr8:8381029 C/G cg15556689 chr8:8085844 FLJ10661 -0.49 -5.28 -0.31 2.66e-7 Cervical cancer; CESC cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg00033643 chr7:134001901 SLC35B4 0.4 5.1 0.3 6.45e-7 Mean platelet volume; CESC cis rs796364 0.806 rs12616905 chr2:201007764 C/G cg23649088 chr2:200775458 C2orf69 -0.55 -5.04 -0.3 8.69e-7 Schizophrenia; CESC cis rs7264396 0.563 rs2425114 chr20:34322346 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.88e-22 Total cholesterol levels; CESC cis rs4737010 0.501 rs34342524 chr8:41633857 G/A cg08923054 chr8:41654455 ANK1 -0.47 -5.83 -0.34 1.59e-8 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs4969178 0.965 rs8075131 chr17:76394595 T/G cg05887092 chr17:76393375 PGS1 0.57 9.02 0.48 3.94e-17 HDL cholesterol levels; CESC trans rs561341 0.941 rs8066558 chr17:30272879 G/T cg20587970 chr11:113659929 NA -1.14 -14.26 -0.66 1.22e-34 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07853084 chr13:73632891 KLF5 0.56 6.52 0.37 3.57e-10 Gut microbiome composition (summer); CESC cis rs80130819 0.748 rs901963 chr12:48734609 A/G cg05342945 chr12:48394962 COL2A1 -0.5 -5.32 -0.31 2.21e-7 Prostate cancer; CESC cis rs7834588 0.523 rs1902237 chr8:63820239 C/G cg20602954 chr8:63776762 NKAIN3 0.3 5.1 0.3 6.36e-7 Response to Vitamin E supplementation; CESC cis rs3741151 0.773 rs73542976 chr11:73127471 A/G cg17517138 chr11:73019481 ARHGEF17 0.94 6.86 0.39 4.87e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 10.51 0.54 8.06e-22 Platelet count; CESC cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg03060546 chr3:49711283 APEH 0.46 5.45 0.32 1.13e-7 Parkinson's disease; CESC cis rs9814567 0.865 rs9834981 chr3:134282279 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.46 -6.17 -0.35 2.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs933688 0.532 rs10072084 chr5:90539203 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.44 5.63 0.33 4.61e-8 Smoking behavior; CESC cis rs7264396 0.563 rs2225950 chr20:34333015 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.73 -0.55 1.57e-22 Total cholesterol levels; CESC cis rs7208859 0.623 rs7503335 chr17:29073962 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs208520 0.802 rs208499 chr6:66932146 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.81 -9.62 -0.51 5.57e-19 Exhaled nitric oxide output; CESC cis rs28386778 0.965 rs2854154 chr17:61981696 C/A cg06601766 chr17:61851465 DDX42;CCDC47 -0.46 -5.56 -0.32 6.5e-8 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10824722 chr1:206506826 NA -0.62 -7.9 -0.44 7.61e-14 Gut microbiome composition (summer); CESC cis rs10504229 0.953 rs6985942 chr8:58173412 T/C cg05313129 chr8:58192883 C8orf71 -0.46 -5.73 -0.33 2.74e-8 Developmental language disorder (linguistic errors); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20095338 chr12:76478402 NAP1L1 -0.42 -6.29 -0.36 1.32e-9 Gambling; CESC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.39 -6.25 -0.36 1.67e-9 Cystic fibrosis severity; CESC cis rs9788682 0.747 rs8043009 chr15:78908154 G/C cg24631222 chr15:78858424 CHRNA5 0.79 9.71 0.51 2.93e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg05340658 chr4:99064831 C4orf37 0.77 11.73 0.58 7.21e-26 Colonoscopy-negative controls vs population controls; CESC cis rs28374715 0.681 rs7168307 chr15:41620534 A/G cg20272979 chr15:41787780 ITPKA 0.43 5.79 0.33 2.02e-8 Ulcerative colitis; CESC cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs17102884 0.506 rs11845397 chr14:75404587 G/A cg11812906 chr14:75593930 NEK9 -0.44 -5.41 -0.32 1.44e-7 Neuroticism; CESC cis rs3126085 1.000 rs3126095 chr1:152309683 G/A cg03465714 chr1:152285911 FLG 0.43 5.22 0.31 3.62e-7 Atopic dermatitis; CESC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg00129232 chr17:37814104 STARD3 -0.57 -7.57 -0.42 6.31e-13 Glomerular filtration rate (creatinine); CESC cis rs9549367 0.713 rs9549682 chr13:113830181 C/T cg00898013 chr13:113819073 PROZ -0.57 -7.72 -0.43 2.32e-13 Platelet distribution width; CESC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg09509183 chr1:209979624 IRF6 0.54 5.74 0.33 2.59e-8 Cleft lip with or without cleft palate; CESC cis rs62408225 1.000 rs55881869 chr6:90968025 C/A cg06866423 chr6:90926672 BACH2 0.46 5.5 0.32 9.01e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg11644478 chr21:40555479 PSMG1 -0.55 -7.57 -0.42 6.38e-13 Menarche (age at onset); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04818274 chr16:69420026 TERF2 -0.49 -6.44 -0.37 5.53e-10 Asthma; CESC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC cis rs599083 0.530 rs546803 chr11:68186392 C/T cg01657329 chr11:68192670 LRP5 0.44 5.07 0.3 7.55e-7 Bone mineral density (spine); CESC cis rs3015497 0.904 rs3015501 chr14:51108524 C/T cg26011998 chr14:51135199 SAV1 -0.41 -5.18 -0.3 4.36e-7 Mean platelet volume; CESC cis rs1691799 0.899 rs903589 chr12:66745835 C/T cg16791601 chr12:66731901 HELB -0.62 -10.33 -0.54 2.96e-21 White blood cell count (basophil); CESC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg17143192 chr8:8559678 CLDN23 0.74 8.34 0.46 4.15e-15 Obesity-related traits; CESC cis rs3015497 0.575 rs8023035 chr14:51162419 A/G cg09863266 chr14:51125203 SAV1 -0.33 -5.07 -0.3 7.64e-7 Mean platelet volume; CESC cis rs2251381 0.565 rs2832279 chr21:30613466 G/T cg24692254 chr21:30365293 RNF160 0.59 7.41 0.41 1.71e-12 Selective IgA deficiency; CESC cis rs17666538 0.585 rs6559063 chr8:623051 C/T cg23958373 chr8:599963 NA 0.81 5.63 0.33 4.61e-8 IgG glycosylation; CESC cis rs7116495 0.881 rs7930142 chr11:71737016 C/T cg10381502 chr11:71823885 C11orf51 -0.64 -5.21 -0.3 3.81e-7 Severe influenza A (H1N1) infection; CESC cis rs4718428 0.705 rs4717331 chr7:66378886 C/T cg12165864 chr7:66369176 NA -0.68 -7.98 -0.44 4.53e-14 Corneal structure; CESC cis rs2455799 0.573 rs2455836 chr3:15754538 A/G cg16303742 chr3:15540471 COLQ -0.39 -6.19 -0.36 2.34e-9 Mean platelet volume; CESC cis rs2262909 1.000 rs431328 chr19:22222236 A/G cg11619707 chr19:22235551 ZNF257 -0.37 -6.28 -0.36 1.34e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs9420 0.961 rs7938083 chr11:57493622 C/A cg19752551 chr11:57585705 CTNND1 -0.38 -5.1 -0.3 6.6e-7 Schizophrenia; CESC cis rs17376456 0.877 rs28633397 chr5:93447048 A/G cg21475434 chr5:93447410 FAM172A 0.82 7.56 0.42 6.81e-13 Diabetic retinopathy; CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg17178900 chr1:205818956 PM20D1 -0.66 -10.82 -0.55 7.95e-23 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02927949 chr13:103426033 C13orf27 0.58 6.28 0.36 1.42e-9 Gut microbiome composition (summer); CESC cis rs4911259 0.552 rs11697394 chr20:31460076 G/A cg13636640 chr20:31349939 DNMT3B -0.56 -7.85 -0.43 1e-13 Inflammatory bowel disease; CESC cis rs17376456 0.877 rs10070390 chr5:93452345 G/A cg25358565 chr5:93447407 FAM172A 1.15 11.8 0.59 4.11e-26 Diabetic retinopathy; CESC cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg07697082 chr8:82753677 SNX16 0.38 5.79 0.33 2.02e-8 Diastolic blood pressure; CESC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg22968622 chr17:43663579 NA -1.19 -16.28 -0.71 8.87e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs8077577 1.000 rs8077577 chr17:18064730 C/T cg16794390 chr17:18148240 FLII 0.43 5.87 0.34 1.27e-8 Obesity-related traits; CESC cis rs11690935 0.959 rs10497374 chr2:172640623 A/G cg13550731 chr2:172543902 DYNC1I2 -1.01 -16.56 -0.71 9.29e-43 Schizophrenia; CESC cis rs7833986 0.501 rs72653967 chr8:56999432 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.54 0.42 7.58e-13 Height; CESC cis rs7666738 0.546 rs10025064 chr4:98914060 A/G cg17366294 chr4:99064904 C4orf37 0.52 6.57 0.37 2.65e-10 Colonoscopy-negative controls vs population controls; CESC cis rs12545109 0.800 rs1348082 chr8:57415016 A/G cg09654669 chr8:57350985 NA -0.46 -6.25 -0.36 1.67e-9 Obesity-related traits; CESC cis rs2439831 0.618 rs8023508 chr15:44176103 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.67 -6.88 -0.39 4.24e-11 Lung cancer in ever smokers; CESC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg25072359 chr17:41440525 NA 0.45 6.17 0.35 2.49e-9 Menopause (age at onset); CESC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg13902645 chr11:5959945 NA -0.66 -9.03 -0.49 3.62e-17 DNA methylation (variation); CESC trans rs11098499 0.754 rs7672372 chr4:120248406 A/G cg25214090 chr10:38739885 LOC399744 0.62 8.69 0.47 3.79e-16 Corneal astigmatism; CESC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg10494973 chr17:80897199 TBCD 0.49 5.66 0.33 3.89e-8 Breast cancer; CESC trans rs11039798 0.588 rs6485857 chr11:48556511 C/A cg15704280 chr7:45808275 SEPT13 0.66 6.67 0.38 1.46e-10 Axial length; CESC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg03060546 chr3:49711283 APEH 0.5 6.76 0.38 8.72e-11 Menarche (age at onset); CESC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg18016565 chr1:150552671 MCL1 0.33 5.16 0.3 4.96e-7 Tonsillectomy; CESC cis rs7843479 0.965 rs11135763 chr8:21813962 A/G cg17168535 chr8:21777572 XPO7 0.5 6.94 0.39 3.07e-11 Mean corpuscular volume; CESC cis rs6942756 0.774 rs66479871 chr7:129009687 T/C cg02491457 chr7:128862824 NA -0.53 -7.28 -0.41 3.77e-12 White matter hyperintensity burden; CESC cis rs11864453 0.647 rs10492814 chr16:72126514 G/A cg01557791 chr16:72042693 DHODH -0.43 -5.57 -0.32 6.39e-8 Fibrinogen levels; CESC cis rs2228479 0.717 rs11644967 chr16:89806614 T/A cg04287289 chr16:89883240 FANCA 0.65 5.67 0.33 3.67e-8 Skin colour saturation; CESC cis rs72781680 0.848 rs72798057 chr2:23976731 T/C cg08917208 chr2:24149416 ATAD2B 0.96 8.7 0.47 3.55e-16 Lymphocyte counts; CESC cis rs9916302 0.706 rs903507 chr17:37726423 A/G cg00129232 chr17:37814104 STARD3 -0.57 -5.84 -0.34 1.51e-8 Glomerular filtration rate (creatinine); CESC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg14393609 chr7:65229607 NA -0.45 -6.02 -0.35 5.91e-9 Aortic root size; CESC cis rs9948 0.655 rs7568206 chr2:97393108 A/C cg01990225 chr2:97406019 LMAN2L -0.87 -7.29 -0.41 3.59e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg22638593 chr5:131593259 PDLIM4 0.42 5.41 0.32 1.44e-7 Breast cancer; CESC cis rs7660520 0.557 rs76004373 chr4:183731011 C/G cg09197432 chr4:183729176 NA 0.58 5.65 0.33 4.07e-8 Pediatric autoimmune diseases; CESC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg08564027 chr20:61660810 NA 0.9 15.86 0.7 2.68e-40 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13453304 chr18:77493499 CTDP1 -0.6 -6.22 -0.36 1.88e-9 Gut microbiome composition (summer); CESC cis rs6831352 0.918 rs2851253 chr4:100043505 G/T cg12011299 chr4:100065546 ADH4 -0.58 -6.71 -0.38 1.21e-10 Alcohol dependence; CESC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg26839252 chr6:160211577 TCP1;MRPL18 0.45 5.23 0.31 3.4e-7 Age-related macular degeneration (geographic atrophy); CESC trans rs4973517 0.833 rs998985 chr2:233071691 A/C cg20998127 chr7:158859224 VIPR2 0.39 6.03 0.35 5.58e-9 Hip circumference adjusted for BMI; CESC cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.64 6.01 0.35 6.2e-9 Lung function (FEV1/FVC); CESC cis rs10883723 0.810 rs7069356 chr10:104254359 G/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs11098499 0.863 rs3775854 chr4:120471971 C/T cg09307838 chr4:120376055 NA 0.91 12.56 0.61 1.08e-28 Corneal astigmatism; CESC cis rs3820068 0.577 rs9728986 chr1:16040603 G/A cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.64e-7 Systolic blood pressure; CESC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg08888203 chr3:10149979 C3orf24 0.45 5.6 0.33 5.47e-8 Alzheimer's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03586379 chr3:140660603 SLC25A36 -0.56 -6.95 -0.39 2.9100000000000002e-11 Ulcerative colitis; CESC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs962856 0.619 rs7564335 chr2:67579967 A/G cg09028215 chr2:67624308 ETAA1 -0.44 -5.32 -0.31 2.2e-7 Pancreatic cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06466203 chr10:89623360 PTEN;KILLIN 0.59 7.05 0.4 1.56e-11 Gut microbiome composition (summer); CESC cis rs8077577 0.747 rs12451698 chr17:18237116 A/G cg16794390 chr17:18148240 FLII 0.4 6.29 0.36 1.31e-9 Obesity-related traits; CESC cis rs8077577 0.708 rs4925151 chr17:18130132 G/C cg16794390 chr17:18148240 FLII -0.43 -6.33 -0.36 1.04e-9 Obesity-related traits; CESC cis rs7216064 1.000 rs7223930 chr17:65842186 G/A cg07042672 chr17:66097459 LOC651250 -0.57 -6.64 -0.38 1.72e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs10506458 0.915 rs56321182 chr12:63392023 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -17.99 -0.74 7.53e-48 Hemostatic factors and hematological phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23913400 chr17:73717552 ITGB4 0.66 7.37 0.41 2.13e-12 Gut microbiome composition (summer); CESC cis rs9467711 0.606 rs9348726 chr6:26605206 G/A cg14345882 chr6:26364793 BTN3A2 0.56 5.97 0.34 7.78e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2953174 0.786 rs2953146 chr2:241515252 A/G cg07929629 chr2:241523174 NA -0.48 -5.83 -0.34 1.63e-8 Bipolar disorder; CESC cis rs892961 0.932 rs55661113 chr17:75408386 A/C cg05865280 chr17:75406074 SEPT9 0.57 11.18 0.57 5.1900000000000004e-24 Airflow obstruction; CESC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.75 0.43 1.94e-13 Prudent dietary pattern; CESC cis rs9549260 0.564 rs4943805 chr13:41270080 A/G cg21288729 chr13:41239152 FOXO1 0.57 6.92 0.39 3.39e-11 Red blood cell count; CESC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.75 -0.33 2.48e-8 Lung cancer; CESC cis rs7937682 0.575 rs1940391 chr11:111776891 G/A cg09085632 chr11:111637200 PPP2R1B 0.94 13.08 0.63 1.67e-30 Primary sclerosing cholangitis; CESC cis rs67478160 0.619 rs11628481 chr14:104241499 C/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.15 -0.4 8.55e-12 Schizophrenia; CESC cis rs7520050 0.778 rs3013597 chr1:46128356 C/A cg03146154 chr1:46216737 IPP 0.52 6.97 0.39 2.55e-11 Red blood cell count;Reticulocyte count; CESC cis rs1045714 0.895 rs4719602 chr7:2647800 G/A cg20813462 chr7:2646259 IQCE 0.65 5.63 0.33 4.68e-8 Urate levels in lean individuals; CESC cis rs4481887 0.861 rs10888345 chr1:248447533 A/G cg00666640 chr1:248458726 OR2T12 0.39 6.67 0.38 1.47e-10 Common traits (Other); CESC cis rs3947 0.855 rs1293327 chr8:11694986 G/A cg00262122 chr8:11665843 FDFT1 -0.51 -5.37 -0.31 1.69e-7 Blood protein levels; CESC cis rs863345 0.967 rs1857251 chr1:158512801 G/A cg12129480 chr1:158549410 OR10X1 -0.32 -6.5 -0.37 4e-10 Pneumococcal bacteremia; CESC cis rs2710642 0.525 rs1386401 chr2:62889906 C/G cg17519650 chr2:63277830 OTX1 0.54 7.08 0.4 1.33e-11 LDL cholesterol levels;LDL cholesterol; CESC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg17971929 chr21:40555470 PSMG1 -0.53 -6.95 -0.39 2.89e-11 Menarche (age at onset); CESC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs6964587 0.934 rs2961019 chr7:91572749 T/G cg17063962 chr7:91808500 NA -0.46 -5.28 -0.31 2.7e-7 Breast cancer; CESC cis rs6089584 0.546 rs6061978 chr20:60615604 C/T cg24733560 chr20:60626293 TAF4 0.44 6.56 0.37 2.84e-10 Body mass index; CESC cis rs4474465 0.790 rs7932315 chr11:78214878 G/A cg27205649 chr11:78285834 NARS2 0.42 5.1 0.3 6.45e-7 Alzheimer's disease (survival time); CESC cis rs117623576 0.941 rs7098334 chr10:32418501 G/T cg03047570 chr10:32398778 NA -0.84 -8.64 -0.47 5.28e-16 Anti-saccade response; CESC trans rs11638815 0.871 rs8033106 chr15:83299461 C/T cg25333056 chr10:135107159 TUBGCP2 0.48 6.28 0.36 1.35e-9 Lipoprotein-associated phospholipase A2 activity change in response to statin therapy; CESC cis rs9925964 0.744 rs12716979 chr16:31011821 T/G cg02466173 chr16:30829666 NA 0.34 5.54 0.32 7.45e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2880765 0.835 rs6497206 chr15:86029225 A/G cg19183879 chr15:85880815 NA -0.24 -5.09 -0.3 6.65e-7 Coronary artery disease; CESC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg13770153 chr20:60521292 NA 0.56 7.23 0.41 5.3e-12 Body mass index; CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg16132339 chr22:24313637 DDTL;DDT -0.41 -6.32 -0.36 1.08e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg03930357 chr16:84150069 MBTPS1 0.48 6.16 0.35 2.76e-9 Tetralogy of Fallot; CESC cis rs7247513 0.797 rs3815914 chr19:12760664 T/C cg01871581 chr19:12707946 ZNF490 -0.72 -10.47 -0.54 1.09e-21 Bipolar disorder; CESC cis rs7937682 0.889 rs490199 chr11:111487890 A/G cg09085632 chr11:111637200 PPP2R1B -0.94 -14.45 -0.66 2.76e-35 Primary sclerosing cholangitis; CESC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs8062405 1.000 rs7498665 chr16:28883241 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg19748678 chr4:122722346 EXOSC9 0.76 10.32 0.54 3.3e-21 Type 2 diabetes; CESC trans rs11039798 0.920 rs12279378 chr11:48571030 A/C cg15704280 chr7:45808275 SEPT13 0.7 6.69 0.38 1.3100000000000001e-10 Axial length; CESC cis rs9549367 0.789 rs9549705 chr13:113888425 T/C cg00898013 chr13:113819073 PROZ -0.54 -7.39 -0.41 1.93e-12 Platelet distribution width; CESC cis rs3733585 0.673 rs4235347 chr4:9951956 C/T cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs868036 0.958 rs12593813 chr15:68036852 C/T cg08079166 chr15:68083412 MAP2K5 0.39 6.19 0.36 2.26e-9 Restless legs syndrome; CESC cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg00745463 chr17:30367425 LRRC37B -0.83 -7.62 -0.42 4.42e-13 Hip circumference adjusted for BMI; CESC cis rs2075371 0.932 rs34664116 chr7:133984878 G/A cg00033643 chr7:134001901 SLC35B4 0.43 5.48 0.32 1.01e-7 Mean platelet volume; CESC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg08736216 chr1:53307985 ZYG11A -0.38 -6.48 -0.37 4.45e-10 Monocyte count; CESC cis rs7937682 0.883 rs512669 chr11:111467893 G/A cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC cis rs5769765 0.908 rs9627800 chr22:50319351 T/C cg26441486 chr22:50317300 CRELD2 0.48 5.78 0.33 2.08e-8 Schizophrenia; CESC cis rs1348850 0.914 rs4341974 chr2:178324879 A/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.73 10.16 0.53 1.07e-20 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg03934478 chr11:495069 RNH1 0.56 5.18 0.3 4.45e-7 Body mass index; CESC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg11644478 chr21:40555479 PSMG1 1.05 16.84 0.72 9.02e-44 Cognitive function; CESC cis rs11792861 0.564 rs3816237 chr9:111718348 T/A cg13535736 chr9:111863775 C9orf5 -0.39 -5.74 -0.33 2.58e-8 Menarche (age at onset); CESC cis rs2066819 1.000 rs79101914 chr12:56729739 A/G cg26714650 chr12:56694279 CS -1.39 -9.17 -0.49 1.33e-17 Psoriasis vulgaris; CESC cis rs4901869 0.864 rs12891575 chr14:59334342 T/A cg02291164 chr14:59296302 NA 0.45 7.59 0.42 5.56e-13 Panic disorder; CESC cis rs3815700 1.000 rs8101356 chr19:33093402 C/T cg24916020 chr19:33096688 ANKRD27 0.6 5.84 0.34 1.56e-8 Eosinophilic esophagitis; CESC cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg24450063 chr1:156163899 SLC25A44 -1.12 -24.35 -0.83 1.43e-69 Testicular germ cell tumor; CESC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg26119090 chr2:26468346 HADHA;HADHB -1.09 -13.48 -0.64 6.79e-32 Gut microbiome composition (summer); CESC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg19717773 chr7:2847554 GNA12 -0.55 -7.83 -0.43 1.15e-13 Height; CESC cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 6.06 0.35 4.68e-9 Total body bone mineral density; CESC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10927875 0.501 rs61782229 chr1:16220118 G/A cg21385522 chr1:16154831 NA -0.9 -10.32 -0.54 3.37e-21 Dilated cardiomyopathy; CESC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg24209194 chr3:40518798 ZNF619 0.49 6.32 0.36 1.12e-9 Renal cell carcinoma; CESC cis rs684232 0.666 rs838372 chr17:566428 C/T cg15660573 chr17:549704 VPS53 -0.63 -8.69 -0.47 3.83e-16 Prostate cancer; CESC cis rs13102973 0.932 rs4130841 chr4:135869673 T/C cg14419869 chr4:135874104 NA -0.4 -6.29 -0.36 1.32e-9 Subjective well-being; CESC cis rs12887734 0.546 rs66676135 chr14:104271504 G/A cg01849466 chr14:104193079 ZFYVE21 -0.44 -5.62 -0.33 4.85e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC trans rs11039798 0.528 rs10839208 chr11:49030456 C/T cg03929089 chr4:120376271 NA 0.62 6.47 0.37 4.6e-10 Axial length; CESC cis rs2072732 0.821 rs1005471 chr1:2952614 T/C cg15211996 chr1:2936768 ACTRT2 0.32 5.93 0.34 9.43e-9 Plateletcrit; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23508591 chr15:75871807 PTPN9 0.48 6.31 0.36 1.15e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs28595532 0.748 rs66615663 chr4:119336701 C/T cg21605333 chr4:119757512 SEC24D 0.93 5.92 0.34 1.02e-8 Cannabis dependence symptom count; CESC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg11366901 chr6:160182831 ACAT2 0.64 8.17 0.45 1.24e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.63 0.33 4.49e-8 Bipolar disorder; CESC trans rs7090925 0.853 rs2892582 chr10:8482310 C/T cg22997768 chr12:11092816 TAS2R14;PRR4;PRH1 -0.47 -6.17 -0.35 2.53e-9 Systemic lupus erythematosus; CESC cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.73 0.55 1.55e-22 Monocyte percentage of white cells; CESC cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg05340658 chr4:99064831 C4orf37 0.78 11.79 0.59 4.44e-26 Colonoscopy-negative controls vs population controls; CESC cis rs820218 0.926 rs820135 chr17:73674977 T/C cg01592526 chr17:73663357 RECQL5;SAP30BP 0.47 6.12 0.35 3.28e-9 Rotator cuff tears; CESC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg12963246 chr6:28129442 ZNF389 0.48 5.85 0.34 1.48e-8 Parkinson's disease; CESC cis rs2688608 0.592 rs10762560 chr10:75495405 T/G cg23231163 chr10:75533350 FUT11 -0.35 -5.28 -0.31 2.63e-7 Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11397033 chr7:83379104 NA -0.54 -6.38 -0.36 8.02e-10 Gut microbiome composition (summer); CESC cis rs6500602 0.702 rs2304634 chr16:4500544 C/T cg08645402 chr16:4508243 NA 0.55 8.78 0.47 2.02e-16 Schizophrenia; CESC cis rs6991838 0.530 rs35038843 chr8:66522498 T/A cg13398993 chr8:66546079 ARMC1 -0.46 -5.65 -0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg27170947 chr2:26402098 FAM59B -0.61 -7.15 -0.4 8.59e-12 Gut microbiome composition (summer); CESC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg04546413 chr19:29218101 NA 0.45 6.61 0.38 2.11e-10 Methadone dose in opioid dependence; CESC trans rs9951602 0.512 rs9952372 chr18:76656295 A/G cg02800362 chr5:177631904 HNRNPAB 0.64 8.35 0.46 3.86e-15 Obesity-related traits; CESC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.26 0.41 4.39e-12 Bipolar disorder; CESC cis rs2439831 0.557 rs13329084 chr15:44151063 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.63 -5.07 -0.3 7.5e-7 Lung cancer in ever smokers; CESC cis rs2070488 0.804 rs13085153 chr3:38461279 A/G cg24069376 chr3:38537580 EXOG 0.36 6.26 0.36 1.51e-9 Electrocardiographic conduction measures; CESC cis rs4654899 0.802 rs2290381 chr1:21213271 C/A cg05370193 chr1:21551575 ECE1 0.38 5.64 0.33 4.32e-8 Superior frontal gyrus grey matter volume; CESC cis rs7044106 0.708 rs991121 chr9:123370345 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.75 0.33 2.46e-8 Hip circumference adjusted for BMI; CESC cis rs5769765 1.000 rs2295408 chr22:50261051 A/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.4 -0.32 1.45e-7 Schizophrenia; CESC cis rs2635047 0.682 rs9960932 chr18:44792445 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.09 0.3 6.89e-7 Educational attainment; CESC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 1.000 rs376551 chr6:167384923 G/A cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.27e-8 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23666278 chr2:171785822 GORASP2 0.55 6.03 0.35 5.56e-9 Gut microbiome composition (summer); CESC cis rs2279817 0.735 rs11580813 chr1:17981913 C/T cg21791023 chr1:18019539 ARHGEF10L 0.58 7.25 0.41 4.61e-12 Neuroticism; CESC cis rs9837602 1.000 rs1688766 chr3:99647850 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.42 0.41 1.61e-12 Breast cancer; CESC cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg20503657 chr10:835505 NA 0.69 6.31 0.36 1.19e-9 Eosinophil percentage of granulocytes; CESC trans rs60843830 1.000 rs62114501 chr2:231741 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 8.18 0.45 1.17e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs17818399 0.788 rs17818315 chr2:46818992 C/T cg02822958 chr2:46747628 ATP6V1E2 0.43 5.21 0.3 3.87e-7 Height; CESC cis rs8067354 0.645 rs2645486 chr17:57885901 T/A cg02344993 chr17:57696989 CLTC 0.67 8.16 0.45 1.33e-14 Hemoglobin concentration; CESC cis rs10504229 0.679 rs16921688 chr8:58054659 T/C cg21724239 chr8:58056113 NA 0.52 5.05 0.3 8.08e-7 Developmental language disorder (linguistic errors); CESC cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg00409905 chr10:38381863 ZNF37A -0.45 -6.04 -0.35 5.25e-9 Extrinsic epigenetic age acceleration; CESC cis rs2180341 1.000 rs6903878 chr6:127638600 C/G cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6.31e-39 Breast cancer; CESC cis rs2073300 1.000 rs6137983 chr20:23469465 C/A cg12062639 chr20:23401060 NAPB 0.94 6.04 0.35 5.14e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9527 0.590 rs2066322 chr10:104909339 T/G cg04362960 chr10:104952993 NT5C2 0.42 5.28 0.31 2.71e-7 Arsenic metabolism; CESC cis rs7772486 0.790 rs9497424 chr6:146225271 C/A cg05347473 chr6:146136440 FBXO30 -0.52 -6.82 -0.39 6.28e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1215050 0.765 rs1530905 chr4:98805705 A/G cg05340658 chr4:99064831 C4orf37 0.52 6.88 0.39 4.36e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs10751667 0.643 rs11246348 chr11:939476 G/C cg06064525 chr11:970664 AP2A2 -0.52 -10.43 -0.54 1.43e-21 Alzheimer's disease (late onset); CESC cis rs950776 0.616 rs647041 chr15:78880481 T/C cg06917634 chr15:78832804 PSMA4 -0.6 -7.84 -0.43 1.08e-13 Sudden cardiac arrest; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg26421448 chr1:224622516 WDR26 -0.48 -6.2 -0.36 2.15e-9 Height; CESC cis rs1670533 0.872 rs10017931 chr4:1060747 G/A cg04106633 chr4:1044584 NA 0.39 5.04 0.3 8.74e-7 Recombination rate (females); CESC cis rs11758351 0.660 rs55643278 chr6:26222888 C/A cg23601095 chr6:26197514 HIST1H3D 0.92 9.82 0.52 1.28e-19 Gout;Renal underexcretion gout; CESC cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg05863683 chr7:1912471 MAD1L1 0.36 5.35 0.31 1.88e-7 Schizophrenia; CESC cis rs1163251 0.902 rs627707 chr1:120217133 C/G cg19096424 chr1:120255104 PHGDH 0.43 5.22 0.31 3.62e-7 Blood metabolite levels; CESC cis rs933688 0.502 rs4916858 chr5:90601290 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.47 -6.23 -0.36 1.87e-9 Smoking behavior; CESC cis rs10411262 0.935 rs2312289 chr19:47175615 G/C cg13467550 chr19:47212573 PRKD2 0.35 5.77 0.33 2.16e-8 Tonsillectomy; CESC cis rs763121 0.853 rs2267395 chr22:39113903 C/T cg06544989 chr22:39130855 UNC84B 0.5 9.6 0.51 6.59e-19 Menopause (age at onset); CESC cis rs62064224 0.765 rs62065463 chr17:30732405 G/T cg09324608 chr17:30823087 MYO1D 0.51 7.72 0.43 2.35e-13 Schizophrenia; CESC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg16145915 chr7:1198662 ZFAND2A -0.49 -7.28 -0.41 3.84e-12 Longevity;Endometriosis; CESC cis rs3820068 0.580 rs7556473 chr1:15996858 C/T cg16988262 chr1:15930761 NA -0.33 -5.06 -0.3 7.7e-7 Systolic blood pressure; CESC cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg21138405 chr5:131827807 IRF1 0.54 9.32 0.5 4.74e-18 Asthma (sex interaction); CESC cis rs9790314 0.936 rs7629987 chr3:161002023 A/C cg04691961 chr3:161091175 C3orf57 -0.4 -5.18 -0.3 4.39e-7 Morning vs. evening chronotype; CESC cis rs3820928 0.874 rs55959848 chr2:227805426 C/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.66 -0.33 3.83e-8 Pulmonary function; CESC cis rs11718455 0.629 rs4082418 chr3:43908243 C/T cg08738300 chr3:44038990 NA -0.37 -5.16 -0.3 4.77e-7 Coronary artery disease; CESC cis rs7089973 0.668 rs7077148 chr10:116644896 A/G cg25233709 chr10:116636983 FAM160B1 0.41 6.56 0.37 2.89e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20095674 chr2:210673274 UNC80 0.43 6.2 0.36 2.14e-9 Fibrinogen levels; CESC cis rs1509123 0.609 rs118144554 chr17:6721816 C/A cg12642237 chr17:6703447 TEKT1 -0.6 -5.06 -0.3 7.77e-7 Blood metabolite levels; CESC cis rs9584850 0.540 rs17574536 chr13:99171040 G/A cg20750642 chr13:99100586 FARP1 -0.4 -5.75 -0.33 2.4e-8 Neuroticism; CESC cis rs9911578 0.935 rs12948039 chr17:57045184 C/T cg05425664 chr17:57184151 TRIM37 -0.4 -5.54 -0.32 7.36e-8 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16532752 chr4:104119610 CENPE 0.57 6.29 0.36 1.34e-9 Gut microbiome composition (summer); CESC cis rs34779708 0.966 rs10508816 chr10:35459976 G/A cg04310649 chr10:35416472 CREM -0.54 -6.54 -0.37 3.16e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs11971186 0.793 rs1204523 chr7:126508102 T/C cg10894441 chr11:111169905 C11orf92;C11orf93 -0.51 -6.55 -0.37 2.9e-10 Chemerin levels; CESC cis rs708547 0.647 rs12621 chr4:57897570 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.51 7.01 0.4 1.96e-11 Response to bleomycin (chromatid breaks); CESC cis rs7809950 0.678 rs79902674 chr7:106866498 A/C cg23024343 chr7:107201750 COG5 -0.56 -6.76 -0.38 8.76e-11 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01764079 chr8:144718741 ZNF623 -0.64 -7.6 -0.42 5.26e-13 Gut microbiome composition (summer); CESC trans rs11039798 1.000 rs8188963 chr11:48685693 C/A cg15704280 chr7:45808275 SEPT13 0.7 6.42 0.37 6.38e-10 Axial length; CESC cis rs7188697 0.882 rs9921370 chr16:58611935 C/A cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 7.6 0.42 5.28e-13 Personality dimensions; CESC cis rs763121 0.853 rs2267393 chr22:39101619 G/C cg21395723 chr22:39101663 GTPBP1 0.49 6.76 0.38 8.89e-11 Menopause (age at onset); CESC cis rs7100689 0.598 rs2342815 chr10:82086532 T/C cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 4.91e-14 Post bronchodilator FEV1; CESC cis rs2832191 0.692 rs2245517 chr21:30357968 C/T cg08807101 chr21:30365312 RNF160 0.91 14.18 0.66 2.38e-34 Dental caries; CESC cis rs7824557 0.602 rs7834139 chr8:11206363 C/G cg21775007 chr8:11205619 TDH 0.58 8.81 0.48 1.71e-16 Retinal vascular caliber; CESC cis rs2191566 0.691 rs55676341 chr19:44587689 G/C cg20607764 chr19:44506953 ZNF230 -0.39 -5.07 -0.3 7.54e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs9457247 1.000 rs408040 chr6:167398903 A/T cg25258033 chr6:167368657 RNASET2 0.4 6.12 0.35 3.43e-9 Crohn's disease; CESC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.36 -0.36 8.99e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10927875 0.632 rs10927864 chr1:16165661 C/G cg21385522 chr1:16154831 NA -1.02 -17.08 -0.72 1.28e-44 Dilated cardiomyopathy; CESC cis rs9287719 0.967 rs10929682 chr2:10732189 C/A cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.35e-8 Prostate cancer; CESC cis rs66573146 0.656 rs56094305 chr4:6956086 C/T cg26116260 chr4:7069785 GRPEL1 -0.79 -5.16 -0.3 4.78e-7 Granulocyte percentage of myeloid white cells; CESC cis rs362296 0.698 rs362283 chr4:3259558 T/C cg08886695 chr4:3369023 RGS12 0.41 5.46 0.32 1.07e-7 Parental longevity (mother's age at death); CESC cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg02773041 chr1:40204384 PPIE 0.53 7.56 0.42 6.49e-13 Blood protein levels; CESC cis rs1062177 1.000 rs62377945 chr5:151208004 C/G cg12924095 chr5:151150029 G3BP1 0.5 6.48 0.37 4.55e-10 Preschool internalizing problems; CESC cis rs2228479 0.850 rs17227057 chr16:89816333 C/T cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs2777491 0.915 rs9302109 chr15:41612180 G/T cg18705301 chr15:41695430 NDUFAF1 -0.6 -8.84 -0.48 1.39e-16 Ulcerative colitis; CESC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg27286337 chr10:134555280 INPP5A 0.67 7.62 0.42 4.43e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs965469 0.779 rs6037581 chr20:3351595 C/T cg25506879 chr20:3388711 C20orf194 -0.49 -5.24 -0.31 3.22e-7 IFN-related cytopenia; CESC cis rs425277 0.565 rs61775448 chr1:2045376 A/G cg19257562 chr1:2043853 PRKCZ 0.38 6.38 0.37 7.7e-10 Height; CESC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg01579765 chr21:45077557 HSF2BP -0.57 -9.91 -0.52 6.75e-20 Mean corpuscular volume; CESC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg15921436 chr17:44337874 NA 0.44 5.55 0.32 7.08e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9486719 0.895 rs3734238 chr6:96996228 A/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.69 -0.33 3.43e-8 Migraine;Coronary artery disease; CESC cis rs9611519 0.894 rs9611486 chr22:41458784 C/G cg03806693 chr22:41940476 POLR3H -0.56 -5.86 -0.34 1.38e-8 Neuroticism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15979344 chr10:99496871 ZFYVE27 -0.46 -6.12 -0.35 3.31e-9 Ulcerative colitis; CESC cis rs67478160 0.643 rs11624184 chr14:104240998 A/G cg01849466 chr14:104193079 ZFYVE21 -0.45 -6.5 -0.37 4.04e-10 Schizophrenia; CESC cis rs2204008 0.577 rs11520050 chr12:38051839 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06622468 chr19:10491460 TYK2 0.63 7.62 0.42 4.61e-13 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg25072359 chr17:41440525 NA 0.5 6.77 0.38 8.41e-11 Menopause (age at onset); CESC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9308731 0.591 rs9308742 chr2:111943621 G/A cg04202892 chr2:111875749 ACOXL 0.37 5.17 0.3 4.61e-7 Chronic lymphocytic leukemia; CESC cis rs12579753 0.719 rs11115060 chr12:82269624 C/T cg21193143 chr12:82153300 PPFIA2 -0.34 -5.16 -0.3 4.75e-7 Resting heart rate; CESC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg06212747 chr3:49208901 KLHDC8B -0.71 -10.82 -0.55 7.92e-23 Menarche (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18356743 chr13:30408050 UBL3 -0.37 -6.25 -0.36 1.61e-9 Gambling; CESC cis rs7208859 0.562 rs8078897 chr17:29106257 T/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1775715 0.870 rs10827001 chr10:32229734 C/T cg18675610 chr10:32216311 ARHGAP12 0.35 5.36 0.31 1.85e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs8062405 0.755 rs62034358 chr16:28587597 G/T cg07382826 chr16:28625726 SULT1A1 0.4 6.52 0.37 3.49e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs10129255 0.518 rs10136903 chr14:107187105 T/C cg23076370 chr14:107095027 NA -0.66 -10.01 -0.52 3.13e-20 Kawasaki disease; CESC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg19901468 chr14:105411992 AHNAK2 0.61 8.92 0.48 7.7e-17 Rheumatoid arthritis; CESC trans rs4824093 0.610 rs56810176 chr22:50303149 G/C cg09872104 chr7:134855509 C7orf49 -0.87 -6.16 -0.35 2.76e-9 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9768139 0.733 rs13309408 chr7:158122261 C/T cg27057461 chr7:158136379 PTPRN2 -0.37 -5.76 -0.33 2.36e-8 Calcium levels; CESC cis rs6963495 0.818 rs56268110 chr7:105166712 T/C cg19920283 chr7:105172520 RINT1 0.7 6.68 0.38 1.39e-10 Bipolar disorder (body mass index interaction); CESC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg17366294 chr4:99064904 C4orf37 0.58 7.76 0.43 1.85e-13 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg14926445 chr8:58193284 C8orf71 -0.5 -5.41 -0.32 1.44e-7 Developmental language disorder (linguistic errors); CESC trans rs561341 0.941 rs8081016 chr17:30331751 A/G cg20587970 chr11:113659929 NA -1.43 -18.64 -0.75 3.98e-50 Hip circumference adjusted for BMI; CESC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg04013166 chr16:89971882 TCF25 0.77 6.55 0.37 3.05e-10 Skin colour saturation; CESC cis rs826838 1.000 rs10506122 chr12:38699232 A/G cg26384229 chr12:38710491 ALG10B 0.84 15.37 0.69 1.45e-38 Heart rate; CESC cis rs1400745 0.756 rs10136352 chr14:35334555 C/T cg16230307 chr14:35515116 FAM177A1 0.45 5.47 0.32 1.06e-7 Monocyte count; CESC cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg11657440 chr19:46296263 DMWD -0.59 -7.73 -0.43 2.24e-13 Coronary artery disease; CESC trans rs1814175 0.817 rs1390676 chr11:50056778 C/T cg03929089 chr4:120376271 NA -0.94 -15.72 -0.69 8.37e-40 Height; CESC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg12463550 chr7:65579703 CRCP -0.5 -6.43 -0.37 5.9e-10 Aortic root size; CESC cis rs2050392 0.590 rs17547917 chr10:30718303 G/A cg02070205 chr10:30722105 MAP3K8 -0.46 -5.42 -0.32 1.33e-7 Inflammatory bowel disease; CESC cis rs3796352 1.000 rs71299622 chr3:52917038 G/A cg12962167 chr3:53033115 SFMBT1 0.64 5.12 0.3 5.99e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs17376456 0.877 rs12153501 chr5:93360866 T/G cg25358565 chr5:93447407 FAM172A 1.1 10.93 0.56 3.31e-23 Diabetic retinopathy; CESC cis rs2228479 0.718 rs62054253 chr16:89896932 T/C cg06558623 chr16:89946397 TCF25 1.06 7.64 0.42 4.04e-13 Skin colour saturation; CESC cis rs2236918 1.000 rs2526699 chr1:242022130 T/C cg17736920 chr1:242011382 EXO1 0.73 9.16 0.49 1.46e-17 Menopause (age at onset); CESC cis rs4654899 0.865 rs6664532 chr1:21515800 G/A cg05370193 chr1:21551575 ECE1 0.46 7.14 0.4 8.84e-12 Superior frontal gyrus grey matter volume; CESC cis rs17253792 0.822 rs77544029 chr14:56087917 T/C cg01858014 chr14:56050164 KTN1 -0.83 -7.03 -0.4 1.7e-11 Putamen volume; CESC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg18016565 chr1:150552671 MCL1 0.34 5.12 0.3 6e-7 Melanoma; CESC cis rs6460942 1.000 rs6460936 chr7:12404913 T/C cg06484146 chr7:12443880 VWDE -0.79 -8.75 -0.47 2.47e-16 Coronary artery disease; CESC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.46 -0.54 1.15e-21 Alzheimer's disease; CESC cis rs9790314 0.846 rs6441371 chr3:161008727 C/A cg03342759 chr3:160939853 NMD3 -0.46 -6.12 -0.35 3.41e-9 Morning vs. evening chronotype; CESC cis rs1256061 0.624 rs1256046 chr14:64729356 A/C cg23250157 chr14:64679961 SYNE2 0.53 7.64 0.42 4.09e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2952156 0.883 rs8077172 chr17:37834977 G/T cg00129232 chr17:37814104 STARD3 -0.73 -10.6 -0.55 4.07e-22 Asthma; CESC cis rs11792861 0.962 rs72607161 chr9:111792640 T/C cg05043794 chr9:111880884 C9orf5 -0.42 -6.93 -0.39 3.25e-11 Menarche (age at onset); CESC cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg26597838 chr10:835615 NA 0.9 9.85 0.52 1.01e-19 Eosinophil percentage of granulocytes; CESC cis rs7301826 0.557 rs7953184 chr12:131284852 T/G cg11011512 chr12:131303247 STX2 -0.48 -5.89 -0.34 1.18e-8 Plasma plasminogen activator levels; CESC cis rs1832871 0.672 rs9456285 chr6:158732819 T/G cg07165851 chr6:158734300 TULP4 0.6 6.55 0.37 2.92e-10 Height; CESC cis rs9916302 0.660 rs4795379 chr17:37674683 T/G cg07936489 chr17:37558343 FBXL20 -0.95 -10.64 -0.55 3e-22 Glomerular filtration rate (creatinine); CESC cis rs72781680 0.851 rs72796397 chr2:24178211 T/A cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs901683 1.000 rs35424022 chr10:45976540 T/C cg16031567 chr10:46195673 NA -0.75 -5.04 -0.3 8.78e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3780486 0.801 rs6476398 chr9:33119241 C/T cg13443165 chr9:33130375 B4GALT1 0.44 6.19 0.36 2.27e-9 IgG glycosylation; CESC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg23758822 chr17:41437982 NA 1.02 15.58 0.69 2.64e-39 Menopause (age at onset); CESC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg17005319 chr11:655579 DEAF1 0.46 5.18 0.3 4.3e-7 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05404161 chr11:62446492 UBXN1 0.61 6.87 0.39 4.57e-11 Gut microbiome composition (summer); CESC cis rs17666538 0.591 rs2878547 chr8:603416 G/A cg23958373 chr8:599963 NA 0.75 6.32 0.36 1.1e-9 IgG glycosylation; CESC cis rs11958404 0.932 rs72818108 chr5:157437883 A/T cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs11997175 0.545 rs7839592 chr8:33666662 T/C ch.8.33884649F chr8:33765107 NA 0.55 6.85 0.39 5.18e-11 Body mass index; CESC cis rs9467711 0.606 rs9379871 chr6:26375854 C/G cg12826209 chr6:26865740 GUSBL1 0.66 5.47 0.32 1.02e-7 Autism spectrum disorder or schizophrenia; CESC cis rs4728302 0.583 rs58955798 chr7:133158420 C/T cg10665199 chr7:133106180 EXOC4 0.53 7.37 0.41 2.16e-12 Intelligence;Intelligence (multi-trait analysis); CESC cis rs11122272 0.701 rs971533 chr1:231522097 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs854765 0.616 rs8070624 chr17:17843396 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.42 5.1 0.3 6.42e-7 Total body bone mineral density; CESC cis rs60843830 0.928 rs62114494 chr2:211317 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.84 10.88 0.56 4.99e-23 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs992157 0.735 rs13388024 chr2:219097773 A/G cg00012203 chr2:219082015 ARPC2 0.84 12.14 0.6 2.8e-27 Colorectal cancer; CESC cis rs3105593 0.965 rs3109891 chr15:50874964 T/C cg08437265 chr15:50716283 USP8 0.41 5.29 0.31 2.61e-7 QT interval; CESC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg03351412 chr1:154909251 PMVK 0.59 7.51 0.42 8.91e-13 Prostate cancer; CESC cis rs13095912 1.000 rs13072759 chr3:185326391 G/A cg11274856 chr3:185301563 NA 0.35 5.5 0.32 8.96e-8 Systolic blood pressure; CESC cis rs910316 0.763 rs13712 chr14:75483812 T/C cg16144293 chr14:75469539 EIF2B2 -0.4 -5.3 -0.31 2.47e-7 Height; CESC cis rs2180341 1.000 rs2144742 chr6:127595786 C/A cg24812749 chr6:127587940 RNF146 1.06 15.23 0.68 4.52e-38 Breast cancer; CESC cis rs977987 0.778 rs4888400 chr16:75425596 G/C cg03315344 chr16:75512273 CHST6 0.4 5.79 0.34 1.99e-8 Dupuytren's disease; CESC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.72 -0.33 2.93e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs9329221 0.683 rs3105738 chr8:9889914 A/T cg15556689 chr8:8085844 FLJ10661 -0.54 -7.2 -0.4 6.29e-12 Neuroticism; CESC cis rs2243480 1.000 rs34815098 chr7:65292254 A/C cg13147721 chr7:65941812 NA -0.84 -8.42 -0.46 2.36e-15 Diabetic kidney disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13673779 chr18:48723081 MEX3C -0.45 -6.2 -0.36 2.14e-9 Gut microbiota (bacterial taxa); CESC cis rs1904096 0.506 rs4693381 chr4:95206855 A/T cg11021082 chr4:95130006 SMARCAD1 0.69 11.54 0.58 3.07e-25 Type 2 diabetes; CESC cis rs6963495 0.745 rs2392749 chr7:105182605 A/G cg19920283 chr7:105172520 RINT1 0.73 8.19 0.45 1.09e-14 Bipolar disorder (body mass index interaction); CESC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg14393609 chr7:65229607 NA -0.42 -5.59 -0.32 5.63e-8 Aortic root size; CESC cis rs897984 0.806 rs10782002 chr16:30946506 A/G cg02466173 chr16:30829666 NA 0.47 7.87 0.44 9.26e-14 Dementia with Lewy bodies; CESC cis rs2243480 1.000 rs55895244 chr7:65387678 C/G cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC cis rs4746818 1.000 rs906217 chr10:70954661 T/C cg04149295 chr10:70884716 VPS26A 0.58 5.07 0.3 7.44e-7 Left atrial antero-posterior diameter; CESC cis rs7084402 0.902 rs1649017 chr10:60288531 T/C cg07615347 chr10:60278583 BICC1 0.59 9.2 0.49 1.13e-17 Refractive error; CESC trans rs561341 0.943 rs508566 chr17:30289861 G/C cg27661571 chr11:113659931 NA -0.83 -7.45 -0.42 1.3e-12 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10780495 chr1:8939136 ENO1 0.55 6.15 0.35 2.78e-9 Gut microbiome composition (summer); CESC cis rs3820928 0.874 rs10178731 chr2:227874232 C/T cg11843606 chr2:227700838 RHBDD1 -0.42 -5.25 -0.31 3.06e-7 Pulmonary function; CESC cis rs35079168 0.923 rs11103473 chr9:137287629 A/T cg00753924 chr9:137298813 RXRA 0.35 5.45 0.32 1.18e-7 Intelligence; CESC cis rs7659604 0.605 rs67772833 chr4:122723106 G/A cg20573242 chr4:122745356 CCNA2 0.61 8.01 0.44 3.57e-14 Type 2 diabetes; CESC cis rs9811920 0.809 rs796976 chr3:99621002 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.44 5.82 0.34 1.7e-8 Axial length; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01809819 chr1:31192165 MATN1 -0.46 -6.36 -0.36 8.89e-10 Height; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg09273779 chr9:35605990 TESK1 -0.47 -6.29 -0.36 1.29e-9 Height; CESC cis rs67478160 0.619 rs1040813 chr14:104306696 T/C cg08213375 chr14:104286397 PPP1R13B 0.53 10.41 0.54 1.75e-21 Schizophrenia; CESC trans rs1814175 0.817 rs4881645 chr11:49791168 G/A cg03929089 chr4:120376271 NA -0.9 -14.97 -0.68 4.06e-37 Height; CESC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg22535103 chr8:58192502 C8orf71 -0.93 -10.36 -0.54 2.49e-21 Developmental language disorder (linguistic errors); CESC cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.38 0.31 1.62e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 11.34 0.57 1.42e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.73 0.38 1.03e-10 Prudent dietary pattern; CESC cis rs3766606 0.505 rs72633047 chr1:7935440 G/A cg00042356 chr1:8021962 PARK7 0.58 5.51 0.32 8.57e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs6466055 0.692 rs13226540 chr7:104999901 G/A cg04380332 chr7:105027541 SRPK2 -0.43 -5.61 -0.33 5.18e-8 Schizophrenia; CESC trans rs9467711 0.606 rs9393707 chr6:26362486 T/C cg06606381 chr12:133084897 FBRSL1 -0.76 -7.08 -0.4 1.28e-11 Autism spectrum disorder or schizophrenia; CESC cis rs6541297 0.703 rs638097 chr1:230310728 C/T cg20703242 chr1:230279135 GALNT2 -0.43 -5.56 -0.32 6.46e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09685104 chr18:13726506 C18orf19;RNMT 0.55 6.59 0.38 2.39e-10 Gut microbiome composition (summer); CESC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.77 0.38 8.38e-11 Bipolar disorder; CESC trans rs7615952 0.599 rs1044215 chr3:125725559 C/G cg07211511 chr3:129823064 LOC729375 -0.59 -7.29 -0.41 3.66e-12 Blood pressure (smoking interaction); CESC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs3733585 0.781 rs13103690 chr4:9972778 T/G cg00071950 chr4:10020882 SLC2A9 -0.77 -13.79 -0.65 5.54e-33 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7267979 1.000 rs6115182 chr20:25410259 G/A cg08601574 chr20:25228251 PYGB -0.38 -5.59 -0.32 5.69e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs12477438 0.520 rs10865029 chr2:99718298 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.61 0.69 2.15e-39 Chronic sinus infection; CESC cis rs2901656 0.934 rs2285170 chr1:172425529 C/G cg03748243 chr1:172413542 C1orf105;PIGC 0.41 5.98 0.34 7.33e-9 Red cell distribution width;Platelet distribution width; CESC cis rs1348850 0.958 rs4893941 chr2:178269531 A/T cg23306229 chr2:178417860 TTC30B 0.64 7.98 0.44 4.35e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg00149659 chr3:10157352 C3orf10 0.6 6.3 0.36 1.27e-9 Alzheimer's disease; CESC cis rs13064411 0.696 rs6438156 chr3:113206929 C/A cg18753928 chr3:113234510 CCDC52 -0.5 -5.9 -0.34 1.11e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs8114671 0.836 rs6142284 chr20:33641367 G/A cg07148914 chr20:33460835 GGT7 -0.41 -5.31 -0.31 2.28e-7 Height; CESC trans rs7246760 1.000 rs113915533 chr19:9881379 A/C cg02900749 chr2:68251473 NA -0.78 -6.71 -0.38 1.2e-10 Pursuit maintenance gain; CESC trans rs7902708 0.920 rs7095383 chr10:54425601 G/T cg26219051 chr22:43739629 SCUBE1 -0.48 -6.19 -0.36 2.25e-9 Bone properties (heel); CESC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg03060546 chr3:49711283 APEH 0.5 6.8 0.39 6.79e-11 Menarche (age at onset); CESC cis rs901683 0.867 rs17157885 chr10:46020094 G/A cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs4450131 0.522 rs11245327 chr10:126358174 T/C cg20435097 chr10:126320824 FAM53B 0.29 5.18 0.3 4.31e-7 White blood cell count (basophil); CESC cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg10523679 chr1:76189770 ACADM -0.65 -6.61 -0.38 2.12e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.7 -0.33 3.23e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs9329221 0.655 rs656319 chr8:9814411 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.58 -0.37 2.48e-10 Neuroticism; CESC cis rs2760061 0.624 rs10442629 chr1:228191070 T/A cg02753203 chr1:228287806 NA 0.78 11.66 0.58 1.19e-25 Diastolic blood pressure; CESC cis rs1707322 0.721 rs10430124 chr1:46221617 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.54 0.42 7.28e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg19592336 chr6:28129416 ZNF389 0.58 7.25 0.41 4.65e-12 Parkinson's disease; CESC cis rs72781680 1.000 rs111229211 chr2:24167417 T/G cg20701182 chr2:24300061 SF3B14 0.62 5.13 0.3 5.5e-7 Lymphocyte counts; CESC cis rs1401999 0.966 rs2037379 chr3:183650330 T/C cg01324343 chr3:183735012 ABCC5 0.65 13.56 0.64 3.53e-32 Anterior chamber depth; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg26248645 chr2:64370690 PELI1 0.48 6.46 0.37 4.97e-10 Neuroticism; CESC cis rs561341 1.000 rs501957 chr17:30314504 C/T cg19193384 chr17:30244184 NA -0.69 -6.53 -0.37 3.32e-10 Hip circumference adjusted for BMI; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01519164 chr14:69619846 DCAF5 0.49 6.18 0.35 2.35e-9 Gut microbiota (bacterial taxa); CESC cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg01579765 chr21:45077557 HSF2BP -0.52 -9.12 -0.49 1.96e-17 Mean corpuscular volume; CESC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.54 7.54 0.42 7.31e-13 Personality dimensions; CESC cis rs3820068 0.608 rs7514858 chr1:16035246 G/A cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.64e-7 Systolic blood pressure; CESC cis rs1461503 0.966 rs10790546 chr11:122838426 C/A cg27398637 chr11:122830231 C11orf63 -0.56 -8.42 -0.46 2.35e-15 Menarche (age at onset); CESC cis rs7116495 0.881 rs7930722 chr11:71737484 C/G cg10381502 chr11:71823885 C11orf51 -0.64 -5.21 -0.3 3.81e-7 Severe influenza A (H1N1) infection; CESC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC cis rs4660261 0.526 rs2040950 chr1:44315113 G/C cg12908607 chr1:44402522 ARTN -0.46 -6.6 -0.38 2.29e-10 Intelligence (multi-trait analysis); CESC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.75 0.33 2.45e-8 Electroencephalogram traits; CESC cis rs10206020 0.885 rs13388254 chr2:1577209 A/G cg12573674 chr2:1569213 NA -0.46 -5.2 -0.3 3.96e-7 IgG glycosylation; CESC cis rs1371867 0.513 rs1542812 chr8:101207064 G/A cg06002616 chr8:101225028 SPAG1 0.31 5.15 0.3 4.98e-7 Atrioventricular conduction; CESC cis rs10191773 0.535 rs12477879 chr2:112969865 C/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.64 -6.47 -0.37 4.77e-10 Yeast infection; CESC cis rs55728055 1.000 rs16989427 chr22:32108475 C/T cg01338084 chr22:32026380 PISD 1.21 7.95 0.44 5.53e-14 Age-related hearing impairment; CESC trans rs877282 0.583 rs12356155 chr10:823940 C/T cg22713356 chr15:30763199 NA 1.02 9.67 0.51 3.88e-19 Uric acid levels; CESC cis rs4843747 0.636 rs11117358 chr16:88105053 T/A cg17633681 chr16:88106987 BANP 0.76 10.4 0.54 1.88e-21 Menopause (age at onset); CESC cis rs11249608 0.548 rs12152869 chr5:178462520 A/G cg01312482 chr5:178451176 ZNF879 -0.45 -6.07 -0.35 4.31e-9 Pubertal anthropometrics; CESC cis rs9486719 1.000 rs12190508 chr6:96898269 T/C cg18709589 chr6:96969512 KIAA0776 -0.54 -5.87 -0.34 1.3e-8 Migraine;Coronary artery disease; CESC cis rs6467136 0.765 rs11767380 chr7:127209302 T/C cg25922125 chr7:127225783 GCC1 -0.37 -5.15 -0.3 5.11e-7 Type 2 diabetes; CESC cis rs897984 0.647 rs8060857 chr16:31002720 G/A cg00531865 chr16:30841666 NA 0.49 6.53 0.37 3.31e-10 Dementia with Lewy bodies; CESC cis rs1580019 0.922 rs1376289 chr7:32486980 C/G cg06627557 chr7:32535165 LSM5;AVL9 -0.87 -11.67 -0.58 1.14e-25 Cognitive ability; CESC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg06481639 chr22:41940642 POLR3H -0.61 -6.47 -0.37 4.81e-10 Vitiligo; CESC trans rs853679 0.546 rs200950 chr6:27835772 A/G cg06606381 chr12:133084897 FBRSL1 -0.83 -7.8 -0.43 1.44e-13 Depression; CESC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg18876405 chr7:65276391 NA -0.51 -7.03 -0.4 1.8e-11 Aortic root size; CESC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg23048001 chr7:2026167 MAD1L1 0.48 6.29 0.36 1.33e-9 Bipolar disorder and schizophrenia; CESC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg11890956 chr21:40555474 PSMG1 -0.92 -14.5 -0.67 1.81e-35 Cognitive function; CESC cis rs7520050 0.966 rs12049588 chr1:46472422 G/A cg03146154 chr1:46216737 IPP -0.46 -5.87 -0.34 1.31e-8 Red blood cell count;Reticulocyte count; CESC cis rs7259376 0.875 rs4932755 chr19:22494816 A/G cg02657401 chr19:22469223 NA -0.26 -5.32 -0.31 2.22e-7 Menopause (age at onset); CESC cis rs9818758 0.607 rs9311439 chr3:49310408 A/G cg00383909 chr3:49044727 WDR6 0.81 6.16 0.35 2.63e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC trans rs11115322 1.000 rs11115323 chr12:83019495 C/T cg02020882 chr3:128336728 NA -0.95 -6.48 -0.37 4.39e-10 Immune response to smallpox vaccine (IL-6); CESC cis rs921968 0.643 rs645796 chr2:219389236 A/G cg02176678 chr2:219576539 TTLL4 0.43 7.75 0.43 2.03e-13 Mean corpuscular hemoglobin concentration; CESC cis rs902774 0.515 rs2363635 chr12:53354622 T/C cg16329197 chr12:53359506 NA -0.62 -8.76 -0.47 2.34e-16 Prostate cancer; CESC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.66 0.33 3.97e-8 Bipolar disorder; CESC cis rs9291683 0.566 rs13122689 chr4:10044648 A/G cg11266682 chr4:10021025 SLC2A9 0.65 12.28 0.6 9.55e-28 Bone mineral density; CESC cis rs7188697 0.922 rs37040 chr16:58578262 T/C cg02549819 chr16:58548995 SETD6 -0.42 -5.29 -0.31 2.55e-7 QT interval; CESC cis rs929596 0.597 rs10173355 chr2:234597321 A/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -6.01 -0.35 6.26e-9 Total bilirubin levels in HIV-1 infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16749093 chr11:65352605 EHBP1L1 0.47 6.33 0.36 1.06e-9 Fibrinogen levels; CESC cis rs6570726 0.791 rs1509213 chr6:145783360 G/A cg23711669 chr6:146136114 FBXO30 -1.0 -15.6 -0.69 2.23e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs6429082 0.791 rs61836205 chr1:235638753 C/G cg26050004 chr1:235667680 B3GALNT2 0.62 7.86 0.43 9.85e-14 Adiposity; CESC cis rs854765 0.619 rs6502636 chr17:17983817 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.62 8.84 0.48 1.38e-16 Total body bone mineral density; CESC cis rs10911251 0.528 rs4652779 chr1:183104552 G/A ch.1.3577855R chr1:183094577 LAMC1 0.85 13.46 0.64 8.11e-32 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13012899 chr14:105685616 BRF1 -0.6 -6.89 -0.39 4.14e-11 Gut microbiome composition (summer); CESC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg17971929 chr21:40555470 PSMG1 1.06 16.44 0.71 2.32e-42 Cognitive function; CESC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg18337363 chr3:52569053 NT5DC2 -0.29 -5.22 -0.31 3.67e-7 Electroencephalogram traits; CESC cis rs1023500 0.573 rs133382 chr22:42471774 C/T cg15557168 chr22:42548783 NA -0.45 -6.5 -0.37 3.87e-10 Schizophrenia; CESC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.59 0.47 7.39e-16 Menopause (age at onset); CESC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg14298792 chr15:30685198 CHRFAM7A -0.44 -5.14 -0.3 5.38e-7 Huntington's disease progression; CESC cis rs7568458 0.636 rs11126995 chr2:85792408 A/T cg02493740 chr2:85810744 VAMP5 -0.55 -8.24 -0.45 7.91e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs3820068 0.705 rs4646075 chr1:15827461 T/C cg18192808 chr1:15853278 DNAJC16 0.47 5.78 0.33 2.05e-8 Systolic blood pressure; CESC cis rs55794721 0.509 rs2375313 chr1:25748235 G/A cg02931644 chr1:25747376 RHCE 0.46 7.85 0.43 1.06e-13 Plateletcrit;Mean corpuscular volume; CESC trans rs853679 0.546 rs200996 chr6:27811828 G/A cg06606381 chr12:133084897 FBRSL1 -0.73 -6.99 -0.39 2.21e-11 Depression; CESC cis rs854765 0.587 rs4077828 chr17:17833644 A/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.29 0.41 3.65e-12 Total body bone mineral density; CESC cis rs7607369 0.714 rs4674334 chr2:219622811 T/C cg02176678 chr2:219576539 TTLL4 -0.5 -8.62 -0.47 6.1e-16 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs3733585 0.699 rs7658170 chr4:9966593 C/T cg02734326 chr4:10020555 SLC2A9 0.39 5.54 0.32 7.3900000000000007e-08 Cleft plate (environmental tobacco smoke interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08355568 chr6:7108248 RREB1 -0.47 -6.01 -0.35 6.12e-9 Fibrinogen levels; CESC cis rs6831352 0.819 rs1230155 chr4:99989259 C/T cg21548116 chr4:100009993 ADH5 0.46 5.06 0.3 7.96e-7 Alcohol dependence; CESC cis rs9908102 0.740 rs60713770 chr17:12912385 A/G cg26162695 chr17:12921313 ELAC2 0.52 5.71 0.33 3.04e-8 Schizophrenia; CESC cis rs3008870 1.000 rs3008858 chr1:67390416 G/C cg02640540 chr1:67518911 SLC35D1 0.49 5.29 0.31 2.6e-7 Lymphocyte percentage of white cells; CESC cis rs7100689 0.646 rs11202724 chr10:82136190 T/C cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs7149337 0.805 rs2999354 chr14:51607179 C/G cg23942311 chr14:51606299 NA 0.48 8.36 0.46 3.56e-15 Cancer; CESC trans rs747782 0.639 rs61649224 chr11:48057640 G/A cg15704280 chr7:45808275 SEPT13 0.67 6.02 0.35 5.74e-9 Intraocular pressure; CESC cis rs250677 0.687 rs250664 chr5:148453823 C/T cg18129178 chr5:148520854 ABLIM3 -0.51 -5.91 -0.34 1.05e-8 Breast cancer; CESC cis rs9811920 0.555 rs68092024 chr3:99691522 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.44 -5.49 -0.32 9.63e-8 Axial length; CESC cis rs9287719 0.601 rs13427815 chr2:10707985 C/T cg00105475 chr2:10696890 NA 0.41 5.59 0.32 5.74e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24947615 chr21:44515479 U2AF1 -0.77 -8.58 -0.47 8.32e-16 Gut microbiome composition (summer); CESC cis rs564309 0.681 rs11581974 chr1:228617063 A/G cg13771378 chr1:228613100 HIST3H3 -0.59 -6.26 -0.36 1.55e-9 Hip circumference (psychosocial stress interaction); CESC cis rs9888739 0.800 rs7200615 chr16:31337155 G/A cg15817542 chr16:31343056 ITGAM -0.51 -6.83 -0.39 5.73e-11 Systemic lupus erythematosus; CESC cis rs4889855 0.530 rs11654265 chr17:78602697 G/A cg16591659 chr17:78472290 NA 0.34 5.33 0.31 2.11e-7 Fractional excretion of uric acid; CESC cis rs2250402 0.510 rs2898984 chr15:40324075 G/C cg20255370 chr15:40268687 EIF2AK4 -0.57 -5.25 -0.31 3.15e-7 Corneal curvature; CESC cis rs12530845 0.623 rs73721673 chr7:135349573 A/T cg23117316 chr7:135346802 PL-5283 -0.59 -6.35 -0.36 9.48e-10 Red blood cell traits; CESC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg02564969 chr6:151773285 C6orf211;RMND1 0.66 9.47 0.5 1.61e-18 Menarche (age at onset); CESC cis rs10979 1.000 rs9373394 chr6:143890776 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.53 -0.37 3.29e-10 Bipolar disorder; CESC cis rs7824557 0.564 rs35009431 chr8:11232788 G/A cg21775007 chr8:11205619 TDH -0.53 -7.4 -0.41 1.84e-12 Retinal vascular caliber; CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.42 8.04 0.44 3.05e-14 Electroencephalogram traits; CESC cis rs9902453 0.967 rs4493117 chr17:28489770 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.43 0.46 2.29e-15 Coffee consumption (cups per day); CESC cis rs2425143 1.000 rs12479473 chr20:34398628 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.88 0.34 1.24e-8 Blood protein levels; CESC cis rs3820068 0.603 rs1122387 chr1:15947282 T/C cg16988262 chr1:15930761 NA 0.34 5.45 0.32 1.13e-7 Systolic blood pressure; CESC cis rs4975709 1.000 rs2279588 chr5:1878021 G/A cg15595755 chr5:1867978 NA 0.47 7.25 0.41 4.67e-12 Cardiovascular disease risk factors; CESC cis rs2070433 0.539 rs2839312 chr21:47958225 T/C cg12379764 chr21:47803548 PCNT 0.62 8.18 0.45 1.17e-14 Lymphocyte counts; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05433637 chr1:1510598 SSU72 0.48 6.88 0.39 4.42e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg22535103 chr8:58192502 C8orf71 -0.94 -9.35 -0.5 3.78e-18 Developmental language disorder (linguistic errors); CESC cis rs314370 0.570 rs314314 chr7:100423841 C/T cg10426581 chr7:100472382 SRRT 0.49 5.46 0.32 1.09e-7 Resting heart rate; CESC cis rs7223966 1.000 rs9903903 chr17:61762044 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.6 -0.33 5.23e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1878931 1.000 rs1878931 chr16:3450907 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.92 12.96 0.62 4.47e-30 Body mass index (adult); CESC cis rs921968 0.643 rs483172 chr2:219428299 A/G cg02176678 chr2:219576539 TTLL4 0.42 7.32 0.41 2.96e-12 Mean corpuscular hemoglobin concentration; CESC cis rs1018836 0.923 rs756569 chr8:91610957 G/A cg16814680 chr8:91681699 NA -0.74 -10.57 -0.54 5.17e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.38 0.63 1.56e-31 Prudent dietary pattern; CESC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg24562669 chr7:97807699 LMTK2 0.48 6.92 0.39 3.3e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg22800045 chr5:56110881 MAP3K1 0.81 9.16 0.49 1.47e-17 Initial pursuit acceleration; CESC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg27170947 chr2:26402098 FAM59B -0.84 -10.0 -0.52 3.41e-20 Gut microbiome composition (summer); CESC cis rs929596 0.755 rs6742078 chr2:234672639 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.67 9.16 0.49 1.45e-17 Total bilirubin levels in HIV-1 infection; CESC cis rs2204008 0.807 rs4123933 chr12:37973539 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.61 0.38 2.1e-10 Bladder cancer; CESC cis rs12142240 0.698 rs72885198 chr1:46812888 C/T cg10495392 chr1:46806563 NSUN4 0.57 6.29 0.36 1.33e-9 Menopause (age at onset); CESC cis rs752010 0.934 rs11210503 chr1:42101134 A/G cg06885757 chr1:42089581 HIVEP3 0.49 7.96 0.44 5e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs748404 0.631 rs28702649 chr15:43648629 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.59 7.38 0.41 2.04e-12 Lung cancer; CESC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg08859206 chr1:53392774 SCP2 0.67 10.03 0.52 2.87e-20 Monocyte count; CESC cis rs8017423 1.000 rs8015379 chr14:90679432 C/T cg14092571 chr14:90743983 NA -0.58 -8.73 -0.47 2.97e-16 Mortality in heart failure; CESC cis rs7582720 1.000 rs116382857 chr2:203751932 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs7726839 0.540 rs12517638 chr5:645484 C/T cg25482853 chr8:67687455 SGK3 0.92 9.68 0.51 3.5e-19 Obesity-related traits; CESC cis rs7084402 0.967 rs11815274 chr10:60328891 A/G cg07615347 chr10:60278583 BICC1 -0.58 -9.01 -0.48 4.24e-17 Refractive error; CESC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg22920501 chr2:26401640 FAM59B -0.66 -7.92 -0.44 6.58e-14 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs74720318 chr14:56099828 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg24675658 chr1:53192096 ZYG11B 0.6 7.55 0.42 7.08e-13 Monocyte count; CESC trans rs877282 1.000 rs71491304 chr10:772982 C/T cg22713356 chr15:30763199 NA 1.12 11.31 0.57 1.87e-24 Uric acid levels; CESC cis rs77106637 0.932 rs3814730 chr11:72555553 G/A cg04827223 chr11:72435913 ARAP1 -0.5 -5.18 -0.3 4.39e-7 Type 2 diabetes; CESC cis rs7542091 0.669 rs11119357 chr1:210042382 C/T cg21951975 chr1:209979733 IRF6 0.45 7.76 0.43 1.82e-13 Monobrow; CESC cis rs2838344 0.776 rs2298561 chr21:45085234 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -8.77 -0.47 2.15e-16 Coronary artery disease; CESC cis rs62064224 0.702 rs735555 chr17:30817450 A/G cg18200150 chr17:30822561 MYO1D -0.56 -8.4 -0.46 2.67e-15 Schizophrenia; CESC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg27532560 chr4:187881888 NA 0.41 6.47 0.37 4.65e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg27398817 chr8:82754497 SNX16 -0.44 -5.61 -0.33 5.08e-8 Diastolic blood pressure; CESC trans rs61931739 0.517 rs11052980 chr12:34036036 T/C cg26384229 chr12:38710491 ALG10B 0.5 6.78 0.38 7.87e-11 Morning vs. evening chronotype; CESC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.62 0.33 4.92e-8 Bipolar disorder; CESC cis rs55728055 0.661 rs5753700 chr22:31971258 C/T cg01338084 chr22:32026380 PISD 0.92 6.54 0.37 3.09e-10 Age-related hearing impairment; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22110492 chr9:136283026 ADAMTS13;REXO4 -0.48 -6.06 -0.35 4.58e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3105593 0.933 rs874665 chr15:50877992 C/T cg08437265 chr15:50716283 USP8 0.41 5.24 0.31 3.23e-7 QT interval; CESC cis rs7044106 0.718 rs1981021 chr9:123388393 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 9.89 0.52 7.73e-20 Hip circumference adjusted for BMI; CESC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg05332525 chr7:65337924 VKORC1L1 0.51 6.23 0.36 1.85e-9 Calcium levels; CESC cis rs13256369 0.789 rs13282500 chr8:8568489 A/T cg17143192 chr8:8559678 CLDN23 0.54 6.32 0.36 1.09e-9 Obesity-related traits; CESC cis rs7818345 1.000 rs4392915 chr8:19308938 T/G cg11303988 chr8:19266685 CSGALNACT1 0.36 6.33 0.36 1.06e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs6500395 1.000 rs1486412 chr16:48651750 A/T cg04672837 chr16:48644449 N4BP1 0.51 6.21 0.36 2.08e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg12288994 chr5:1860383 NA 0.41 6.78 0.38 7.8e-11 Cardiovascular disease risk factors; CESC cis rs5753618 0.529 rs5749298 chr22:31941032 C/T cg02404636 chr22:31891804 SFI1 0.44 5.99 0.35 6.95e-9 Colorectal cancer; CESC cis rs454510 0.857 rs838990 chr1:120193252 A/G cg11530693 chr1:120165357 ZNF697 0.43 5.58 0.32 6.07e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg18230493 chr5:56204884 C5orf35 -0.73 -8.65 -0.47 5.17e-16 Initial pursuit acceleration; CESC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg06808227 chr14:105710500 BRF1 -0.58 -6.88 -0.39 4.31e-11 Mean platelet volume;Platelet distribution width; CESC cis rs367615 0.552 rs2963024 chr5:108730773 C/T cg17395555 chr5:108820864 NA -0.42 -7.05 -0.4 1.6e-11 Colorectal cancer (SNP x SNP interaction); CESC cis rs1577917 0.958 rs10944168 chr6:86680156 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.08 -0.35 4.29e-9 Response to antipsychotic treatment; CESC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg12463550 chr7:65579703 CRCP -0.48 -6.17 -0.35 2.6e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02751449 chr3:142443340 TRPC1 0.56 6.29 0.36 1.33e-9 Gut microbiome composition (summer); CESC trans rs12599106 0.707 rs2163977 chr16:34916134 A/G cg03395511 chr6:291903 DUSP22 -0.66 -8.18 -0.45 1.21e-14 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02423323 chr4:146100633 OTUD4 -0.55 -6.51 -0.37 3.78e-10 Gut microbiome composition (summer); CESC cis rs2279817 0.863 rs35871295 chr1:17984468 A/T cg21791023 chr1:18019539 ARHGEF10L -0.66 -7.97 -0.44 4.73e-14 Neuroticism; CESC cis rs11098499 0.780 rs10013652 chr4:120292256 A/G cg09307838 chr4:120376055 NA 0.86 11.74 0.58 6.58e-26 Corneal astigmatism; CESC cis rs7927592 0.763 rs10896327 chr11:68235275 G/C cg20283391 chr11:68216788 NA -0.45 -5.58 -0.32 5.81e-8 Total body bone mineral density; CESC cis rs7100689 0.646 rs1934692 chr10:82125734 C/A cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs910316 0.763 rs175450 chr14:75590340 G/A cg11812906 chr14:75593930 NEK9 -0.82 -13.14 -0.63 1.07e-30 Height; CESC cis rs73206853 0.563 rs16940992 chr12:111207515 C/T cg12870014 chr12:110450643 ANKRD13A -0.69 -7.23 -0.41 5.18e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs4911253 0.509 rs66499347 chr20:31448696 C/T cg13636640 chr20:31349939 DNMT3B -0.67 -9.39 -0.5 2.83e-18 Lymphocyte counts; CESC cis rs4555082 0.834 rs4412909 chr14:105759226 T/C cg27165867 chr14:105738592 BRF1 -0.52 -5.55 -0.32 6.93e-8 Mean platelet volume;Platelet distribution width; CESC cis rs6121246 0.909 rs1994250 chr20:30287494 A/G cg13852791 chr20:30311386 BCL2L1 0.79 8.3 0.45 5.47e-15 Mean corpuscular hemoglobin; CESC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg11764359 chr7:65958608 NA -0.66 -8.67 -0.47 4.31e-16 Aortic root size; CESC cis rs7937682 0.924 rs4630327 chr11:111539327 C/T cg09085632 chr11:111637200 PPP2R1B 0.97 16.43 0.71 2.69e-42 Primary sclerosing cholangitis; CESC cis rs2832077 0.943 rs11701445 chr21:30160807 C/T cg03476357 chr21:30257390 N6AMT1 -0.51 -5.54 -0.32 7.32e-8 Cognitive test performance; CESC cis rs9486715 0.867 rs4131519 chr6:96964939 G/A cg06623918 chr6:96969491 KIAA0776 0.81 11.56 0.58 2.67e-25 Headache; CESC cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 0.967 rs1267542 chr17:56654690 T/C cg05425664 chr17:57184151 TRIM37 0.49 6.71 0.38 1.18e-10 Intelligence (multi-trait analysis); CESC cis rs1461503 0.932 rs6589962 chr11:122843535 G/A cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs523522 0.962 rs9788155 chr12:120938408 G/A cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs9682041 0.660 rs34158232 chr3:170115360 T/C cg11886554 chr3:170076028 SKIL 0.75 6.6 0.38 2.23e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs1729951 0.575 rs361244 chr3:136697506 C/T cg15507776 chr3:136538369 TMEM22 0.4 5.06 0.3 8.02e-7 Neuroticism; CESC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg16325326 chr1:53192061 ZYG11B -0.89 -15.22 -0.68 5.28e-38 Monocyte count; CESC cis rs3540 0.512 rs8033818 chr15:91075535 C/T cg10434728 chr15:90938212 IQGAP1 -0.42 -7.22 -0.41 5.4e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs11792861 0.962 rs72607161 chr9:111792640 T/C cg13535736 chr9:111863775 C9orf5 -0.51 -6.69 -0.38 1.32e-10 Menarche (age at onset); CESC cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg13607699 chr17:42295918 UBTF -0.46 -5.79 -0.34 1.95e-8 Total body bone mineral density; CESC cis rs55692468 0.520 rs62180799 chr2:153302108 G/A cg04681845 chr2:153283485 FMNL2 0.29 5.91 0.34 1.06e-8 Intraocular pressure; CESC cis rs2243480 1.000 rs4718333 chr7:65772758 T/C cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC cis rs17376456 0.877 rs10044066 chr5:93437580 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.27 0.31 2.85e-7 Diabetic retinopathy; CESC cis rs694739 0.894 rs887314 chr11:64053157 T/G cg02228329 chr11:64053129 BAD;GPR137 0.67 8.56 0.47 9.07e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs3126085 0.935 rs1552995 chr1:152171427 A/G cg03465714 chr1:152285911 FLG -0.45 -5.51 -0.32 8.46e-8 Atopic dermatitis; CESC cis rs34375054 0.738 rs3751181 chr12:125626535 A/G cg06287003 chr12:125626642 AACS -0.34 -5.35 -0.31 1.87e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs7843479 0.965 rs17616085 chr8:21857267 C/T cg17168535 chr8:21777572 XPO7 0.48 6.65 0.38 1.62e-10 Mean corpuscular volume; CESC cis rs2404602 0.692 rs8043474 chr15:76974723 T/C cg26408565 chr15:76604113 ETFA -0.39 -5.72 -0.33 2.94e-8 Blood metabolite levels; CESC cis rs12477438 1.000 rs6732980 chr2:99921613 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -7.84 -0.43 1.13e-13 Chronic sinus infection; CESC cis rs16867321 0.694 rs11889207 chr2:181424527 A/C cg23363182 chr2:181467187 NA -0.5 -7.15 -0.4 8.5e-12 Obesity; CESC cis rs7917772 0.619 rs2251772 chr10:104470918 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.51 5.75 0.33 2.45e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6502050 0.805 rs7225560 chr17:80160884 C/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.55 -0.37 3.05e-10 Life satisfaction; CESC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs8072100 0.840 rs2136751 chr17:45456093 A/G cg08085267 chr17:45401833 C17orf57 -0.54 -7.23 -0.41 5.16e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1059312 0.966 rs12368452 chr12:129277164 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -9.86 -0.52 9.39e-20 Systemic lupus erythematosus; CESC cis rs4727027 0.727 rs1568944 chr7:148873497 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 5.76 0.33 2.3e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs875971 0.898 rs6977501 chr7:65693342 T/C cg26939375 chr7:64535504 NA -0.47 -6.22 -0.36 1.89e-9 Aortic root size; CESC trans rs17307778 1.000 rs4437989 chr11:25358786 T/C cg22888484 chr20:37075185 SNHG11 -0.62 -6.11 -0.35 3.51e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs892961 0.932 rs6501954 chr17:75414398 G/C cg05865280 chr17:75406074 SEPT9 0.63 12.77 0.62 1.96e-29 Airflow obstruction; CESC cis rs6752107 1.000 rs35300242 chr2:234168790 G/A cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.39 5.94 0.34 9.02e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg04369109 chr6:150039330 LATS1 -0.43 -5.91 -0.34 1.05e-8 Lung cancer; CESC cis rs16854884 0.586 rs11914731 chr3:143725594 A/G cg01302019 chr3:143689584 C3orf58 -0.33 -5.2 -0.3 4.05e-7 Economic and political preferences (feminism/equality); CESC cis rs892961 0.899 rs35217221 chr17:75412385 G/A cg05865280 chr17:75406074 SEPT9 0.62 12.43 0.61 2.89e-28 Airflow obstruction; CESC cis rs11190604 0.943 rs3750631 chr10:102279294 A/G cg07080220 chr10:102295463 HIF1AN 0.68 6.29 0.36 1.31e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs11587400 0.679 rs6537834 chr1:115108870 T/C cg12756093 chr1:115239321 AMPD1 0.43 5.76 0.33 2.27e-8 Autism; CESC cis rs2836633 1.000 rs2836634 chr21:40068230 T/A cg12884169 chr21:40033163 ERG 0.33 5.3 0.31 2.46e-7 Coronary artery disease; CESC cis rs10779751 0.610 rs2486921 chr1:11124943 G/A cg08854313 chr1:11322531 MTOR 0.77 10.41 0.54 1.73e-21 Body mass index; CESC trans rs6828577 0.862 rs298995 chr4:119625273 G/A cg05098011 chr1:151736092 OAZ3;MRPL9 0.48 6.01 0.35 6e-9 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs684232 0.666 rs366151 chr17:598311 A/C cg15660573 chr17:549704 VPS53 -0.66 -9.31 -0.5 5.09e-18 Prostate cancer; CESC cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg25554036 chr4:6271136 WFS1 0.52 8.47 0.46 1.68e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs644799 0.710 rs3748253 chr11:95519506 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.8 0.59 4.17e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7408868 0.520 rs10417567 chr19:15308068 C/T cg14696996 chr19:15285081 NOTCH3 -0.96 -9.34 -0.5 4.13e-18 Pulse pressure; CESC cis rs6430585 0.528 rs75524146 chr2:136725459 C/T cg07169764 chr2:136633963 MCM6 1.29 17.68 0.74 9.44e-47 Corneal structure; CESC cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg07636037 chr3:49044803 WDR6 -0.85 -13.2 -0.63 6.28e-31 Menarche (age at onset); CESC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg24531977 chr5:56204891 C5orf35 0.84 11.2 0.57 4.3e-24 Initial pursuit acceleration; CESC cis rs763014 0.931 rs62030903 chr16:638323 T/A cg07343612 chr16:622815 PIGQ -0.51 -6.95 -0.39 2.81e-11 Height; CESC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg15445000 chr17:37608096 MED1 0.39 6.31 0.36 1.17e-9 Glomerular filtration rate (creatinine); CESC cis rs7590368 0.673 rs17456162 chr2:10948090 C/T cg15705551 chr2:10952987 PDIA6 -0.52 -5.08 -0.3 7.2e-7 Educational attainment (years of education); CESC cis rs17376456 0.877 rs10514380 chr5:93409370 C/T cg25358565 chr5:93447407 FAM172A 1.13 11.34 0.57 1.45e-24 Diabetic retinopathy; CESC cis rs2991971 0.810 rs12738318 chr1:45929589 A/G cg06784218 chr1:46089804 CCDC17 0.27 5.12 0.3 5.94e-7 High light scatter reticulocyte count; CESC cis rs4803468 0.967 rs11083619 chr19:41913267 A/C cg09537434 chr19:41945824 ATP5SL -1.09 -19.79 -0.77 3.84e-54 Height; CESC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg23758822 chr17:41437982 NA 1.05 16.25 0.71 1.17e-41 Menopause (age at onset); CESC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.79 0.39 7.29e-11 Bipolar disorder; CESC cis rs644799 0.542 rs10831418 chr11:95468828 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.48 6.11 0.35 3.58e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9296092 0.538 rs9469491 chr6:33521545 A/G cg13560919 chr6:33536144 NA 0.67 10.9 0.56 4.32e-23 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs10242455 0.702 rs28753399 chr7:98997259 C/T cg18809830 chr7:99032528 PTCD1 -0.91 -6.3 -0.36 1.22e-9 Blood metabolite levels; CESC cis rs116095464 1.000 rs7736 chr5:314935 T/C cg22857025 chr5:266934 NA -1.2 -10.6 -0.55 4.2e-22 Breast cancer; CESC cis rs929354 1.000 rs929354 chr7:157045557 C/T cg05182265 chr7:156933206 UBE3C 0.41 5.77 0.33 2.21e-8 Body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18778933 chr5:52760204 NA 0.42 6.08 0.35 4.26e-9 Gut microbiota (bacterial taxa); CESC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg25204440 chr1:209979598 IRF6 0.63 7.97 0.44 4.79e-14 Cleft lip with or without cleft palate; CESC cis rs559928 0.606 rs55970968 chr11:63961433 C/T cg18225595 chr11:63971243 STIP1 0.69 6.2 0.36 2.17e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs6951245 0.810 rs117800627 chr7:1081075 G/C cg24642844 chr7:1081250 C7orf50 -0.76 -9.37 -0.5 3.35e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9443645 0.869 rs9343827 chr6:79501036 A/G cg05283184 chr6:79620031 NA -0.43 -6.75 -0.38 9.12e-11 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs425277 1.000 rs1401138 chr1:2063149 C/T cg24578937 chr1:2090814 PRKCZ 0.54 8.96 0.48 5.82e-17 Height; CESC cis rs7829975 0.511 rs2980426 chr8:8145609 T/C cg06636001 chr8:8085503 FLJ10661 0.62 7.94 0.44 5.75e-14 Mood instability; CESC cis rs7474896 0.515 rs675628 chr10:38305331 C/G cg00409905 chr10:38381863 ZNF37A 0.46 5.07 0.3 7.48e-7 Obesity (extreme); CESC trans rs3780486 0.757 rs10813949 chr9:33123464 G/A cg20290983 chr6:43655470 MRPS18A 0.99 18.2 0.75 1.39e-48 IgG glycosylation; CESC cis rs897080 0.552 rs1067405 chr2:44674861 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.31 0.31 2.35e-7 Height; CESC trans rs62103177 0.810 rs62103194 chr18:77629482 G/A cg05926928 chr17:57297772 GDPD1 1.18 10.14 0.53 1.27e-20 Opioid sensitivity; CESC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg18200150 chr17:30822561 MYO1D -0.6 -8.95 -0.48 6.27e-17 Schizophrenia; CESC cis rs3767633 0.858 rs10753645 chr1:161815364 T/C cg09175582 chr1:161736000 ATF6 0.86 6.85 0.39 5.21e-11 IgG glycosylation; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg02072376 chr1:153606637 C1orf77;S100A13 -0.48 -6.59 -0.38 2.37e-10 Thyroid stimulating hormone; CESC cis rs295140 0.506 rs4673855 chr2:201136143 A/G cg23649088 chr2:200775458 C2orf69 -0.46 -6.16 -0.35 2.67e-9 QT interval; CESC cis rs2486288 0.656 rs8024620 chr15:45574329 C/T cg21132104 chr15:45694354 SPATA5L1 -0.6 -7.31 -0.41 3.23e-12 Glomerular filtration rate; CESC cis rs897080 0.515 rs1085450 chr2:44650698 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.93 0.34 9.59e-9 Height; CESC cis rs9322193 0.962 rs9688750 chr6:149978769 T/C cg13206674 chr6:150067644 NUP43 0.41 5.8 0.34 1.87e-8 Lung cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10757852 chr3:141319363 RASA2 0.47 6.33 0.36 1.03e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs709400 0.597 rs1013650 chr14:103909203 G/A cg12935359 chr14:103987150 CKB -0.51 -7.49 -0.42 1.06e-12 Body mass index; CESC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.59 5.81 0.34 1.82e-8 Cerebrospinal P-tau181p levels; CESC cis rs1153858 1.000 rs1365610 chr15:45694610 C/T cg21132104 chr15:45694354 SPATA5L1 0.86 11.67 0.58 1.14e-25 Homoarginine levels; CESC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.21 -0.36 2.01e-9 Schizophrenia; CESC cis rs71403859 0.730 rs12931191 chr16:71621373 A/T cg08717414 chr16:71523259 ZNF19 0.78 7.19 0.4 6.64e-12 Post bronchodilator FEV1; CESC cis rs8017423 0.935 rs11628906 chr14:90738002 C/T cg14092571 chr14:90743983 NA 0.54 8.28 0.45 5.95e-15 Mortality in heart failure; CESC cis rs8077577 0.945 rs62072496 chr17:18124743 G/A cg16794390 chr17:18148240 FLII 0.47 6.09 0.35 4.05e-9 Obesity-related traits; CESC trans rs7319358 0.844 rs7337382 chr13:79550458 A/G cg11055926 chr10:111683227 XPNPEP1 -0.41 -6.02 -0.35 5.68e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22370370 chr17:47439802 ZNF652 0.55 6.06 0.35 4.65e-9 Gut microbiome composition (summer); CESC cis rs6456156 0.846 rs9364891 chr6:167516319 C/T cg07741184 chr6:167504864 NA -0.34 -5.83 -0.34 1.58e-8 Primary biliary cholangitis; CESC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg23281280 chr6:28129359 ZNF389 0.54 7.05 0.4 1.53e-11 Parkinson's disease; CESC cis rs2120019 1.000 rs2120019 chr15:75334184 T/C cg17294928 chr15:75287854 SCAMP5 -0.74 -8.31 -0.45 5.03e-15 Blood trace element (Zn levels); CESC cis rs10743315 0.599 rs11044451 chr12:19365798 C/T cg02471346 chr12:19282374 PLEKHA5 -0.6 -6.37 -0.36 8.52e-10 Gut microbiota (bacterial taxa); CESC cis rs3747547 0.539 rs75396486 chr9:38123834 A/T cg13774184 chr9:37916125 SHB -0.67 -6.03 -0.35 5.38e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs7552167 0.925 rs7546025 chr1:24510252 T/C cg01960748 chr1:24522592 NA -0.42 -5.23 -0.31 3.44e-7 Psoriasis vulgaris; CESC cis rs7071206 0.947 rs1877998 chr10:79411740 C/T cg07817648 chr10:79422355 NA -0.86 -10.92 -0.56 3.71e-23 Bone mineral density; CESC cis rs2292884 0.505 rs77856818 chr2:238402830 G/A cg14458575 chr2:238380390 NA 0.71 6.11 0.35 3.63e-9 Prostate cancer; CESC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg14298792 chr15:30685198 CHRFAM7A 0.46 5.56 0.32 6.72e-8 Huntington's disease progression; CESC cis rs9039 1.000 rs17652208 chr16:9196463 C/T cg08831531 chr16:9218945 NA -0.58 -7.35 -0.41 2.46e-12 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09379601 chr19:12992224 DNASE2 -0.45 -6.52 -0.37 3.5e-10 Gambling; CESC cis rs2228479 0.850 rs1800355 chr16:89813194 C/T cg19635926 chr16:89946313 TCF25 0.67 5.04 0.3 8.66e-7 Skin colour saturation; CESC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.46 -0.32 1.08e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07728084 chr10:21683123 NA -0.62 -6.83 -0.39 5.9e-11 Gut microbiome composition (summer); CESC cis rs1670533 1.000 rs10007978 chr4:1060984 A/T cg27284194 chr4:1044797 NA 0.47 6.07 0.35 4.4e-9 Recombination rate (females); CESC cis rs7845219 0.539 rs13271644 chr8:95853948 A/G cg13393036 chr8:95962371 TP53INP1 -0.34 -6.43 -0.37 5.88e-10 Type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09479758 chr16:11890209 NA -0.5 -6.18 -0.35 2.41e-9 Ulcerative colitis; CESC cis rs4835473 0.831 rs10428468 chr4:144895257 C/T cg25736465 chr4:144833511 NA 0.39 5.97 0.34 7.43e-9 Immature fraction of reticulocytes; CESC cis rs2816062 0.786 rs735946 chr1:18901323 T/C cg18795169 chr1:18902165 NA -0.93 -17.75 -0.74 5.32e-47 Urate levels in lean individuals; CESC trans rs7893279 0.543 rs11597737 chr10:18959091 A/C cg23539753 chr2:231280698 SP100 0.45 6.0 0.35 6.31e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg24675658 chr1:53192096 ZYG11B 0.69 9.98 0.52 3.91e-20 Monocyte count; CESC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg22968622 chr17:43663579 NA 0.79 10.59 0.55 4.29e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2228479 0.850 rs62054599 chr16:89808850 C/G cg14709524 chr16:89940631 TCF25 0.94 7.08 0.4 1.27e-11 Skin colour saturation; CESC trans rs208520 0.874 rs208473 chr6:66917265 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -10.02 -0.52 3.11e-20 Exhaled nitric oxide output; CESC cis rs11785693 0.862 rs11774126 chr8:4979583 A/C cg26367366 chr8:4980734 NA 0.9 8.27 0.45 6.5e-15 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.05 0.3 8.1e-7 Colonoscopy-negative controls vs population controls; CESC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg07870213 chr5:140052090 DND1 0.65 6.78 0.38 7.75e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg07952391 chr2:88470173 THNSL2 -0.53 -7.79 -0.43 1.53e-13 Response to metformin (IC50); CESC cis rs2262909 1.000 rs765527 chr19:22129555 A/G cg11619707 chr19:22235551 ZNF257 0.33 5.48 0.32 9.82e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC trans rs3942852 0.774 rs1039481 chr11:48182237 G/A cg03929089 chr4:120376271 NA -0.66 -7.24 -0.41 4.83e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg09177884 chr7:1199841 ZFAND2A -0.49 -6.25 -0.36 1.67e-9 Longevity;Endometriosis; CESC cis rs7223966 1.000 rs9903897 chr17:61716705 T/A cg11494091 chr17:61959527 GH2 0.38 5.44 0.32 1.24e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg11752832 chr7:134001865 SLC35B4 0.53 6.78 0.38 7.76e-11 Mean platelet volume; CESC cis rs7772486 0.875 rs854146 chr6:146341033 A/G cg23711669 chr6:146136114 FBXO30 0.88 12.86 0.62 9.55e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs67478160 0.643 rs2024667 chr14:104211529 T/G cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.06 -0.4 1.45e-11 Schizophrenia; CESC cis rs8072100 0.764 rs2644349 chr17:45641743 G/A cg08085267 chr17:45401833 C17orf57 0.41 5.3 0.31 2.46e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg09491104 chr22:46646882 C22orf40 -0.51 -6.16 -0.35 2.69e-9 LDL cholesterol;Cholesterol, total; CESC cis rs1005277 0.505 rs200936 chr10:38134935 T/C cg25427524 chr10:38739819 LOC399744 -0.68 -10.02 -0.52 3.01e-20 Extrinsic epigenetic age acceleration; CESC cis rs116095464 1.000 rs56095714 chr5:311256 C/T cg22857025 chr5:266934 NA -1.25 -7.68 -0.43 3e-13 Breast cancer; CESC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg00129232 chr17:37814104 STARD3 0.59 7.59 0.42 5.46e-13 Glomerular filtration rate (creatinine); CESC cis rs2243480 0.908 rs4718273 chr7:65216099 G/A cg25894440 chr7:65020034 NA 0.63 5.26 0.31 2.92e-7 Diabetic kidney disease; CESC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 6.22 0.36 1.88e-9 Bipolar disorder; CESC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg08888203 chr3:10149979 C3orf24 0.52 6.65 0.38 1.63e-10 Alzheimer's disease; CESC cis rs8016982 0.633 rs7141288 chr14:81710232 C/A cg01989461 chr14:81687754 GTF2A1 0.72 11.21 0.57 3.87e-24 Schizophrenia; CESC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg05564831 chr3:52568323 NT5DC2 0.45 6.89 0.39 4.03e-11 Bipolar disorder; CESC trans rs4308128 0.657 rs272051 chr2:116619655 A/G cg17910586 chr3:52479098 SEMA3G -0.43 -6.12 -0.35 3.43e-9 Suicide attempts in major depressive disorder; CESC cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg23711669 chr6:146136114 FBXO30 0.84 11.04 0.56 1.43e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs10751667 0.666 rs7395267 chr11:962326 C/A cg01483505 chr11:975446 AP2A2 0.36 5.05 0.3 8.13e-7 Alzheimer's disease (late onset); CESC trans rs208520 0.690 rs864314 chr6:66814830 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -25.02 -0.84 9.4e-72 Exhaled nitric oxide output; CESC trans rs35110281 0.782 rs7282933 chr21:45046988 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 7.02 0.4 1.88e-11 Mean corpuscular volume; CESC trans rs11098499 0.722 rs17595727 chr4:120262074 C/T cg25214090 chr10:38739885 LOC399744 -0.62 -8.63 -0.47 5.96e-16 Corneal astigmatism; CESC cis rs71636778 0.543 rs36109400 chr1:27247822 G/A cg12203394 chr1:27248618 NUDC 0.66 5.55 0.32 6.85e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs9948 0.786 rs56797569 chr2:97413555 G/T cg01990225 chr2:97406019 LMAN2L -0.96 -7.6 -0.42 5.16e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.48 0.42 1.1e-12 Prudent dietary pattern; CESC cis rs9457247 1.000 rs2149090 chr6:167372764 T/C cg07741184 chr6:167504864 NA -0.3 -5.39 -0.31 1.6e-7 Crohn's disease; CESC cis rs7223966 1.000 rs7209435 chr17:61712964 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.44 0.42 1.37e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg03188948 chr7:1209495 NA 0.73 7.02 0.4 1.85e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg25427524 chr10:38739819 LOC399744 -0.71 -10.4 -0.54 1.84e-21 Extrinsic epigenetic age acceleration; CESC cis rs2282802 0.677 rs9686454 chr5:139627813 T/C cg26211634 chr5:139558579 C5orf32 0.51 7.39 0.41 1.93e-12 Intelligence (multi-trait analysis); CESC trans rs4950322 0.563 rs6686480 chr1:146583568 G/A cg04954894 chr8:38089920 DDHD2 -0.58 -6.36 -0.36 8.8e-10 Protein quantitative trait loci; CESC cis rs7089973 0.872 rs7074729 chr10:116632257 C/G cg25233709 chr10:116636983 FAM160B1 0.34 5.03 0.3 9.07e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs12464483 0.591 rs72800120 chr2:30897122 G/A cg17749961 chr2:30669863 LCLAT1 0.66 6.84 0.39 5.49e-11 Pre-treatment pain in head and neck squamous cell carcinoma; CESC cis rs2425143 1.000 rs13038622 chr20:34319343 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.49 -0.42 1.03e-12 Blood protein levels; CESC cis rs6831352 0.734 rs2602857 chr4:100030318 G/A cg13256891 chr4:100009986 ADH5 0.68 7.84 0.43 1.07e-13 Alcohol dependence; CESC cis rs3820928 0.933 rs1429267 chr2:227767593 G/C cg05526886 chr2:227700861 RHBDD1 -0.43 -5.63 -0.33 4.53e-8 Pulmonary function; CESC cis rs12682352 0.579 rs7006589 chr8:8668486 A/G cg06636001 chr8:8085503 FLJ10661 0.41 5.03 0.3 9.1e-7 Neuroticism; CESC cis rs7580658 0.926 rs79789049 chr2:128145472 G/A cg10021288 chr2:128175891 PROC -0.42 -6.47 -0.37 4.69e-10 Protein C levels; CESC cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2573652 0.928 rs2581348 chr15:100514063 C/T cg09918751 chr15:100517450 ADAMTS17 -0.37 -7.21 -0.41 5.75e-12 Height; CESC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg24250549 chr1:154909240 PMVK 0.61 8.44 0.46 2.07e-15 Prostate cancer; CESC cis rs1048238 0.506 rs56352596 chr1:16297592 G/A cg21385522 chr1:16154831 NA 0.47 6.03 0.35 5.38e-9 Systolic blood pressure; CESC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg18876405 chr7:65276391 NA -0.49 -5.33 -0.31 2.12e-7 Aortic root size; CESC cis rs7130144 0.541 rs7941653 chr11:130460365 C/A cg26307797 chr11:130446613 NA -0.8 -6.53 -0.37 3.43e-10 Urate levels in lean individuals; CESC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.43 -5.8 -0.34 1.93e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4604732 0.631 rs75320597 chr1:247626751 T/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7116495 1.000 rs3018302 chr11:71790942 A/C cg10381502 chr11:71823885 C11orf51 -0.66 -5.33 -0.31 2.12e-7 Severe influenza A (H1N1) infection; CESC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg23281280 chr6:28129359 ZNF389 0.49 6.37 0.36 8.34e-10 Parkinson's disease; CESC cis rs4595586 1.000 rs4384412 chr12:39218113 T/C cg26384229 chr12:38710491 ALG10B -0.37 -5.21 -0.3 3.81e-7 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06074314 chr2:70475575 TIA1 -0.45 -6.45 -0.37 5.38e-10 Gambling; CESC cis rs7089973 0.872 rs35628210 chr10:116630031 G/A cg23260525 chr10:116636907 FAM160B1 0.37 6.24 0.36 1.68e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs3733585 0.664 rs17245436 chr4:9958169 A/G cg02734326 chr4:10020555 SLC2A9 -0.43 -5.93 -0.34 9.22e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.13e-12 Tonsillectomy; CESC cis rs7091068 0.566 rs7098349 chr10:95514907 A/C cg20715218 chr10:95462985 C10orf4 0.56 5.37 0.31 1.74e-7 Urinary tract infection frequency; CESC cis rs62064224 0.720 rs8078837 chr17:30763537 A/G cg24550644 chr17:30846204 MYO1D -0.35 -5.14 -0.3 5.24e-7 Schizophrenia; CESC cis rs7584330 0.554 rs13390883 chr2:238432619 A/T cg14458575 chr2:238380390 NA 0.48 5.34 0.31 2.03e-7 Prostate cancer; CESC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.46e-17 Gut microbiome composition (summer); CESC cis rs27434 0.607 rs695965 chr5:96148366 C/T cg16492584 chr5:96139282 ERAP1 -0.41 -5.97 -0.34 7.62e-9 Ankylosing spondylitis; CESC cis rs3859192 0.599 rs34933056 chr17:38162983 G/A cg17467752 chr17:38218738 THRA -0.44 -5.86 -0.34 1.37e-8 White blood cell count; CESC cis rs8002861 0.967 rs7994883 chr13:44478805 A/G cg14210620 chr13:44453864 C13orf31;CCDC122 -0.4 -5.17 -0.3 4.68e-7 Leprosy; CESC cis rs2708240 0.577 rs851715 chr7:147526906 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.38 -5.88 -0.34 1.22e-8 QT interval (drug interaction); CESC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs734999 0.588 rs6701238 chr1:2520500 G/A cg20673091 chr1:2541236 MMEL1 0.43 7.14 0.4 9.15e-12 Ulcerative colitis; CESC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg18876405 chr7:65276391 NA -0.66 -9.04 -0.49 3.46e-17 Aortic root size; CESC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg25072359 chr17:41440525 NA 0.51 7.49 0.42 1.05e-12 Menopause (age at onset); CESC cis rs9527 1.000 rs12416687 chr10:104629011 T/C cg04362960 chr10:104952993 NT5C2 0.5 5.42 0.32 1.32e-7 Arsenic metabolism; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17130815 chr7:2558891 LFNG -0.45 -6.6 -0.38 2.18e-10 Gambling; CESC trans rs1814175 0.645 rs28447324 chr11:50046629 C/A cg03929089 chr4:120376271 NA -0.93 -15.32 -0.69 2.24e-38 Height; CESC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg11764359 chr7:65958608 NA -0.64 -8.27 -0.45 6.39e-15 Aortic root size; CESC cis rs17826219 0.636 rs7221463 chr17:29080551 A/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Body mass index; CESC cis rs62344088 0.590 rs6889904 chr5:177264 A/C cg02160872 chr5:212506 CCDC127 -0.67 -5.22 -0.31 3.61e-7 Asthma (childhood onset); CESC trans rs11098499 0.789 rs10212719 chr4:120254437 T/C cg25214090 chr10:38739885 LOC399744 0.64 8.96 0.48 5.98e-17 Corneal astigmatism; CESC cis rs9815354 0.951 rs1716674 chr3:41902972 G/C cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.46e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg02935154 chr7:12443704 VWDE -0.59 -6.31 -0.36 1.14e-9 Coronary artery disease; CESC trans rs4650994 0.525 rs2761463 chr1:178557137 T/C cg05059571 chr16:84539110 KIAA1609 0.39 6.02 0.35 5.7e-9 HDL cholesterol levels;HDL cholesterol; CESC cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg14784868 chr12:69753453 YEATS4 0.83 12.94 0.62 5.29e-30 Blood protein levels; CESC cis rs677665 0.722 rs10746487 chr1:9338689 T/C cg25755851 chr1:9335794 NA -0.63 -7.52 -0.42 8.31e-13 Eosinophil percentage of white cells; CESC cis rs72945132 0.882 rs10466703 chr11:70218548 C/T cg00319359 chr11:70116639 PPFIA1 0.71 6.78 0.38 7.58e-11 Coronary artery disease; CESC cis rs2439831 1.000 rs690002 chr15:43729349 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.82 11.89 0.59 2.04e-26 Lung cancer in ever smokers; CESC cis rs9309473 1.000 rs11903916 chr2:73815328 G/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.49 -0.37 4.23e-10 Metabolite levels; CESC cis rs9614461 0.609 rs9614653 chr22:45767391 A/G cg23503501 chr22:45809793 SMC1B;RIBC2 -0.65 -6.74 -0.38 1.01e-10 Tonsillectomy; CESC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg24154853 chr7:158122151 PTPRN2 0.43 6.78 0.38 7.65e-11 Calcium levels; CESC cis rs6558174 0.965 rs6558172 chr8:22492052 C/T cg03733263 chr8:22462867 KIAA1967 0.49 6.38 0.37 7.71e-10 Breast cancer; CESC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg23221052 chr5:179740743 GFPT2 -0.66 -8.72 -0.47 3.06e-16 Height; CESC cis rs7659604 1.000 rs28618203 chr4:122663935 T/C cg19671926 chr4:122722719 EXOSC9 -0.44 -5.23 -0.31 3.46e-7 Type 2 diabetes; CESC cis rs727505 0.954 rs59673207 chr7:124596982 G/C cg23710748 chr7:124431027 NA -0.45 -7.08 -0.4 1.27e-11 Lewy body disease; CESC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.14 21.25 0.79 3.66e-59 Prudent dietary pattern; CESC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg05025164 chr4:1340916 KIAA1530 0.42 5.65 0.33 4.21e-8 Longevity; CESC trans rs10489896 0.541 rs16843133 chr1:234564255 A/G cg23817893 chr11:86085932 CCDC81 0.43 6.04 0.35 5.15e-9 Cognitive test performance; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27182915 chr1:150241589 APH1A 0.62 6.68 0.38 1.42e-10 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs12173244 chr5:269524 G/A cg22857025 chr5:266934 NA -1.3 -18.8 -0.76 1.12e-50 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02930615 chr19:18966003 UPF1 -0.59 -6.88 -0.39 4.32e-11 Gut microbiome composition (summer); CESC cis rs6460942 0.555 rs7803268 chr7:12306793 G/A cg20607287 chr7:12443886 VWDE -0.76 -8.16 -0.45 1.34e-14 Coronary artery disease; CESC cis rs1983891 0.874 rs3747744 chr6:41516351 A/G cg20194872 chr6:41519635 FOXP4 0.57 8.19 0.45 1.1e-14 Prostate cancer; CESC cis rs1957429 0.520 rs230715 chr14:65320549 G/C cg23373153 chr14:65346875 NA -0.74 -5.8 -0.34 1.86e-8 Pediatric areal bone mineral density (radius); CESC cis rs79839061 0.610 rs1564282 chr4:852313 C/T cg07828340 chr4:882639 GAK 0.98 7.46 0.42 1.27e-12 Intelligence (multi-trait analysis); CESC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.51 -0.32 8.35e-8 Huntington's disease progression; CESC cis rs2637266 0.626 rs846616 chr10:78547311 A/G cg18941641 chr10:78392320 NA 0.41 7.84 0.43 1.12e-13 Pulmonary function; CESC cis rs11098499 0.954 rs28572238 chr4:120316686 T/G cg09307838 chr4:120376055 NA 0.92 12.46 0.61 2.41e-28 Corneal astigmatism; CESC cis rs1065656 0.571 rs12149777 chr16:1834724 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.43 -6.12 -0.35 3.44e-9 Insulin-like growth factors; CESC cis rs7937682 0.575 rs1346180 chr11:111715570 G/C cg22437258 chr11:111473054 SIK2 -0.47 -5.35 -0.31 1.86e-7 Primary sclerosing cholangitis; CESC cis rs2742417 0.624 rs2673029 chr3:45758867 A/G cg04837898 chr3:45731254 SACM1L -0.48 -6.55 -0.37 2.96e-10 Response to anti-depressant treatment in major depressive disorder; CESC cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg06544989 chr22:39130855 UNC84B -0.48 -7.79 -0.43 1.52e-13 Menopause (age at onset); CESC cis rs62344088 0.590 rs62345236 chr5:283519 G/A cg22857025 chr5:266934 NA -1.22 -9.0 -0.48 4.49e-17 Asthma (childhood onset); CESC cis rs7937682 1.000 rs11213973 chr11:111538903 A/T cg09085632 chr11:111637200 PPP2R1B -0.95 -15.2 -0.68 6.01e-38 Primary sclerosing cholangitis; CESC cis rs5747327 0.874 rs2401164 chr22:18131226 C/T cg19898043 chr22:18121309 BCL2L13 -0.41 -5.16 -0.3 4.8e-7 Myeloid white cell count;Granulocyte count; CESC cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.75 0.47 2.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2573652 0.722 rs12914180 chr15:100544416 T/C cg00587665 chr15:100533223 ADAMTS17 -0.39 -6.41 -0.37 6.47e-10 Height; CESC trans rs2727020 0.576 rs61885308 chr11:49343363 G/A cg15704280 chr7:45808275 SEPT13 -0.69 -9.12 -0.49 1.95e-17 Coronary artery disease; CESC trans rs11098499 0.863 rs7678400 chr4:120461957 G/A cg25214090 chr10:38739885 LOC399744 0.67 9.24 0.49 8.09e-18 Corneal astigmatism; CESC cis rs6662572 0.737 rs4434876 chr1:46270129 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.11 -0.3 6.16e-7 Blood protein levels; CESC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg02221750 chr19:17393354 ANKLE1 -0.51 -6.23 -0.36 1.79e-9 Systemic lupus erythematosus; CESC cis rs10540 1.000 rs10540 chr11:494662 G/A cg03352830 chr11:487213 PTDSS2 0.74 7.24 0.41 4.78e-12 Body mass index; CESC cis rs5753037 0.543 rs140122 chr22:30138908 C/G cg01021169 chr22:30184971 ASCC2 -0.55 -7.87 -0.44 9.3e-14 Type 1 diabetes; CESC cis rs1953600 0.818 rs2152546 chr10:81906384 G/T cg00277334 chr10:82204260 NA -0.48 -6.84 -0.39 5.43e-11 Sarcoidosis; CESC trans rs8014252 0.667 rs10148586 chr14:70807623 G/A cg03123320 chr1:229394665 NA -0.49 -6.27 -0.36 1.45e-9 Plasma estrone levels in resected estrogen-receptor positive breast cancer; CESC cis rs2228479 0.850 rs11641147 chr16:89813589 C/T cg19635926 chr16:89946313 TCF25 0.68 5.17 0.3 4.67e-7 Skin colour saturation; CESC cis rs1707322 1.000 rs10890382 chr1:46469674 A/G cg05343316 chr1:45956843 TESK2 0.49 5.83 0.34 1.61e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg13798912 chr7:905769 UNC84A 0.6 5.98 0.34 7.1e-9 Cerebrospinal P-tau181p levels; CESC cis rs17253792 0.822 rs77544029 chr14:56087917 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.98 0.34 7.23e-9 Putamen volume; CESC cis rs7072216 0.763 rs7910014 chr10:100172110 C/T cg26618903 chr10:100175079 PYROXD2 -0.38 -5.86 -0.34 1.38e-8 Metabolite levels; CESC trans rs9467711 0.790 rs66488313 chr6:26631568 G/T cg06606381 chr12:133084897 FBRSL1 -1.07 -7.69 -0.43 2.98e-13 Autism spectrum disorder or schizophrenia; CESC cis rs7647973 0.848 rs4292260 chr3:49148890 T/C cg07636037 chr3:49044803 WDR6 0.9 12.49 0.61 1.87e-28 Menarche (age at onset); CESC cis rs28489187 0.706 rs233057 chr1:85798855 T/C cg16011679 chr1:85725395 C1orf52 0.48 5.68 0.33 3.58e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg24308560 chr3:49941425 MST1R 0.59 8.47 0.46 1.76e-15 Body mass index; CESC cis rs8020095 0.571 rs10138850 chr14:67606768 A/G cg19548862 chr14:67692701 FAM71D 0.47 5.6 0.33 5.47e-8 Depression (quantitative trait); CESC cis rs4919694 1.000 rs17881215 chr10:104629236 G/C cg04362960 chr10:104952993 NT5C2 0.69 6.56 0.37 2.84e-10 Arsenic metabolism; CESC cis rs4919087 1.000 rs10786327 chr10:99071408 C/T cg25902810 chr10:99078978 FRAT1 0.72 10.73 0.55 1.48e-22 Monocyte count; CESC trans rs9467711 0.606 rs12174631 chr6:26373150 C/T cg06606381 chr12:133084897 FBRSL1 -0.76 -7.04 -0.4 1.64e-11 Autism spectrum disorder or schizophrenia; CESC cis rs7660520 0.524 rs4862101 chr4:183733177 T/C cg12483801 chr4:183727862 NA 0.76 6.97 0.39 2.47e-11 Pediatric autoimmune diseases; CESC cis rs6831352 0.879 rs67311928 chr4:100048999 A/G cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg19828298 chr1:3713105 LRRC47 0.44 6.02 0.35 5.66e-9 Obesity-related traits; CESC cis rs2997447 0.761 rs61776620 chr1:26457980 T/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.41 0.32 1.44e-7 QRS complex (12-leadsum); CESC cis rs7520050 0.751 rs2991975 chr1:46024526 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.79 -0.33 2.01e-8 Red blood cell count;Reticulocyte count; CESC cis rs7845219 0.544 rs7015841 chr8:95920193 A/C cg16049864 chr8:95962084 TP53INP1 -0.5 -7.48 -0.42 1.06e-12 Type 2 diabetes; CESC cis rs17253792 0.822 rs75897560 chr14:56090965 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs17253792 0.822 rs113649689 chr14:56088065 G/A cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg17143192 chr8:8559678 CLDN23 0.77 9.05 0.49 3.19e-17 Obesity-related traits; CESC cis rs6912958 0.712 rs6454640 chr6:88370352 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.35 5.77 0.33 2.22e-8 Monocyte percentage of white cells; CESC cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.698 rs13202939 chr6:109649655 A/G cg01475377 chr6:109611718 NA -0.4 -5.47 -0.32 1.03e-7 Reticulocyte fraction of red cells; CESC cis rs72781680 0.898 rs12622290 chr2:23979894 C/G cg08917208 chr2:24149416 ATAD2B 0.96 8.7 0.47 3.55e-16 Lymphocyte counts; CESC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 10.06 0.53 2.23e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg10556349 chr10:835070 NA 0.58 5.48 0.32 9.7e-8 Eosinophil percentage of granulocytes; CESC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg11764359 chr7:65958608 NA -0.78 -10.74 -0.55 1.44e-22 Aortic root size; CESC cis rs9487051 0.676 rs13195816 chr6:109598624 T/C cg21918786 chr6:109611834 NA -0.38 -5.65 -0.33 4.23e-8 Reticulocyte fraction of red cells; CESC cis rs4604732 0.536 rs61184655 chr1:247651342 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.44 5.64 0.33 4.36e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg22920501 chr2:26401640 FAM59B -0.69 -8.19 -0.45 1.1e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27445169 chr11:65769623 BANF1;EIF1AD 0.58 6.24 0.36 1.74e-9 Gut microbiome composition (summer); CESC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg10053473 chr17:62856997 LRRC37A3 -0.66 -8.86 -0.48 1.17e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs644799 0.710 rs10831427 chr11:95508383 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.78 11.68 0.58 1.03e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.26 0.31 3.02e-7 Electroencephalogram traits; CESC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC cis rs6694270 0.529 rs35417699 chr1:19105105 C/T cg19637330 chr1:19110922 NA -0.48 -5.93 -0.34 9.65e-9 Drug-induced liver injury (nitrofurantoin); CESC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg24642844 chr7:1081250 C7orf50 -0.65 -8.26 -0.45 7.08e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg26408565 chr15:76604113 ETFA -0.42 -6.08 -0.35 4.19e-9 Blood metabolite levels; CESC cis rs4727027 0.704 rs2888600 chr7:148908562 C/T cg23583168 chr7:148888333 NA -0.92 -16.22 -0.71 1.45e-41 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2637266 1.000 rs7082587 chr10:78386328 C/T cg18941641 chr10:78392320 NA 0.43 8.35 0.46 3.96e-15 Pulmonary function; CESC cis rs250677 0.522 rs1432798 chr5:148383345 C/G cg18129178 chr5:148520854 ABLIM3 -0.43 -5.49 -0.32 9.64e-8 Breast cancer; CESC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.07 11.07 0.56 1.14e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg05863683 chr7:1912471 MAD1L1 0.44 6.8 0.39 6.93e-11 Bipolar disorder and schizophrenia; CESC cis rs3749237 0.595 rs885592 chr3:49497883 T/G cg06212747 chr3:49208901 KLHDC8B 0.49 6.65 0.38 1.64e-10 Resting heart rate; CESC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg27297192 chr10:134578999 INPP5A 0.4 5.13 0.3 5.54e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg17718321 chr1:152188247 HRNR -0.54 -8.85 -0.48 1.26e-16 Inflammatory skin disease; CESC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg26939375 chr7:64535504 NA 0.75 10.64 0.55 3.11e-22 Aortic root size; CESC cis rs11650494 0.901 rs74659133 chr17:47336931 C/T cg08112188 chr17:47440006 ZNF652 0.99 6.28 0.36 1.36e-9 Prostate cancer; CESC cis rs6575793 0.553 rs61993004 chr14:101030579 G/A cg18516195 chr14:101012996 BEGAIN 0.43 5.22 0.31 3.56e-7 Menarche (age at onset); CESC cis rs7945705 0.902 rs7930026 chr11:9013639 T/C cg12365402 chr11:9010492 NRIP3 0.43 7.0 0.39 2.14e-11 Hemoglobin concentration; CESC cis rs8077889 0.956 rs6503476 chr17:41850163 C/T cg26893861 chr17:41843967 DUSP3 0.86 10.56 0.54 5.49e-22 Triglycerides; CESC cis rs6964587 1.000 rs13224513 chr7:91601465 G/A cg17063962 chr7:91808500 NA 0.57 7.84 0.43 1.14e-13 Breast cancer; CESC trans rs11098499 0.955 rs11944880 chr4:120159334 A/G cg25214090 chr10:38739885 LOC399744 -0.63 -8.44 -0.46 2.05e-15 Corneal astigmatism; CESC cis rs11250098 0.574 rs4240672 chr8:10767917 G/A cg27411982 chr8:10470053 RP1L1 -0.41 -5.1 -0.3 6.47e-7 Morning vs. evening chronotype; CESC cis rs3091242 0.933 rs61775174 chr1:25787313 G/A cg03538708 chr1:25844672 NA 0.39 5.86 0.34 1.38e-8 Erythrocyte sedimentation rate; CESC cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.42 -6.95 -0.39 2.78e-11 Personality dimensions; CESC cis rs7917772 0.536 rs12357172 chr10:104388549 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.59 7.14 0.4 9.11e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25560965 chr12:12510064 LOH12CR1;LOH12CR2 0.56 6.68 0.38 1.38e-10 Gut microbiome composition (summer); CESC cis rs9287719 0.870 rs10167676 chr2:10753140 G/A cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs738322 0.753 rs5756968 chr22:38595240 C/T cg25457927 chr22:38595422 NA 0.38 7.2 0.4 6.37e-12 Cutaneous nevi; CESC cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.79 7.44 0.42 1.36e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs35520189 0.806 rs11123151 chr2:113668005 T/G cg06156847 chr2:113672199 IL1F7 0.38 5.66 0.33 3.86e-8 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs28595532 0.748 rs72670249 chr4:119336823 G/T cg21605333 chr4:119757512 SEC24D 1.01 5.58 0.32 5.98e-8 Cannabis dependence symptom count; CESC cis rs17125944 0.505 rs74642116 chr14:53213507 A/G cg00686598 chr14:53173677 PSMC6 1.36 11.65 0.58 1.34e-25 Alzheimer's disease (late onset); CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg12963246 chr6:28129442 ZNF389 0.58 7.72 0.43 2.41e-13 Depression; CESC cis rs854765 0.647 rs9303144 chr17:17977355 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.62 8.74 0.47 2.8e-16 Total body bone mineral density; CESC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg16145915 chr7:1198662 ZFAND2A -0.49 -7.11 -0.4 1.11e-11 Longevity;Endometriosis; CESC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg04414720 chr1:150670196 GOLPH3L 0.5 6.49 0.37 4.21e-10 Melanoma; CESC cis rs477692 0.612 rs58103386 chr10:131319958 C/A cg24747557 chr10:131355152 MGMT -0.37 -5.09 -0.3 6.87e-7 Response to temozolomide; CESC cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg04455712 chr21:45112962 RRP1B 0.39 5.81 0.34 1.81e-8 Mean corpuscular volume; CESC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg20243544 chr17:37824526 PNMT 0.53 6.97 0.39 2.49e-11 Self-reported allergy; CESC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg16049864 chr8:95962084 TP53INP1 -0.51 -7.82 -0.43 1.22e-13 Type 2 diabetes; CESC cis rs710216 0.536 rs710222 chr1:43413653 A/G cg03128534 chr1:43423976 SLC2A1 0.69 10.39 0.54 1.92e-21 Red cell distribution width; CESC cis rs6831352 0.959 rs6532796 chr4:100042242 C/T cg13256891 chr4:100009986 ADH5 -0.73 -8.42 -0.46 2.39e-15 Alcohol dependence; CESC cis rs17039065 0.920 rs7688259 chr4:109435575 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.68 6.32 0.36 1.11e-9 Gut microbiome composition (summer); CESC cis rs644799 0.965 rs11021313 chr11:95506907 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.66 0.67 4.91e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7267979 1.000 rs4815421 chr20:25386509 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.39e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs6662572 0.737 rs9429179 chr1:46514198 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.2 0.3 4.03e-7 Blood protein levels; CESC cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg15605315 chr1:45957053 TESK2 0.48 6.24 0.36 1.75e-9 High light scatter reticulocyte count; CESC cis rs4073582 0.595 rs2508657 chr11:66043898 G/A cg14036092 chr11:66035641 RAB1B 0.56 7.87 0.44 9.14e-14 Gout; CESC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg06600287 chr1:53387719 ECHDC2 -0.29 -5.04 -0.3 8.48e-7 Monocyte count; CESC cis rs6121246 0.529 rs6058152 chr20:30178107 G/A cg13852791 chr20:30311386 BCL2L1 0.57 5.5 0.32 9.14e-8 Mean corpuscular hemoglobin; CESC cis rs7223966 0.921 rs2854207 chr17:61947107 C/G cg11494091 chr17:61959527 GH2 0.41 5.62 0.33 4.78e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg06028605 chr16:24865363 SLC5A11 0.54 8.07 0.44 2.39e-14 Intelligence (multi-trait analysis); CESC cis rs36051895 0.632 rs62543560 chr9:5175938 C/T cg02405213 chr9:5042618 JAK2 -0.47 -5.36 -0.31 1.79e-7 Pediatric autoimmune diseases; CESC cis rs10465746 0.775 rs4907186 chr1:84340753 G/T cg10977910 chr1:84465055 TTLL7 0.56 7.74 0.43 2.09e-13 Obesity-related traits; CESC cis rs763121 0.853 rs7289577 chr22:39042214 C/G cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg20151795 chr6:28129481 ZNF389 0.48 6.27 0.36 1.47e-9 Depression; CESC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg07870213 chr5:140052090 DND1 0.62 6.7 0.38 1.21e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs734999 0.588 rs10910098 chr1:2533250 C/A cg20673091 chr1:2541236 MMEL1 0.44 7.36 0.41 2.28e-12 Ulcerative colitis; CESC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg05564831 chr3:52568323 NT5DC2 0.44 6.58 0.37 2.57e-10 Bipolar disorder; CESC cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2415984 0.579 rs61993337 chr14:46965297 C/T cg14871534 chr14:47121158 RPL10L -0.35 -5.22 -0.31 3.7e-7 Number of children ever born; CESC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg17372223 chr3:52568218 NT5DC2 0.39 5.84 0.34 1.53e-8 Electroencephalogram traits; CESC trans rs921968 0.541 rs561570 chr2:219379348 T/A cg15547669 chr20:2781122 CPXM1 0.36 6.03 0.35 5.54e-9 Mean corpuscular hemoglobin concentration; CESC cis rs9583531 0.689 rs4773244 chr13:111383937 A/T cg24331049 chr13:111365604 ING1 -0.8 -11.65 -0.58 1.37e-25 Coronary artery disease; CESC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg11644478 chr21:40555479 PSMG1 1.02 16.76 0.72 1.74e-43 Cognitive function; CESC trans rs1994135 0.586 rs7308214 chr12:33713834 T/A cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.26e-13 Resting heart rate; CESC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg00149659 chr3:10157352 C3orf10 0.73 8.73 0.47 2.9e-16 Alzheimer's disease; CESC cis rs2072499 0.778 rs41265025 chr1:156163906 C/T cg24450063 chr1:156163899 SLC25A44 0.96 12.08 0.6 4.83e-27 Testicular germ cell tumor; CESC cis rs4604732 0.678 rs74154674 chr1:247625685 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12477438 0.561 rs2084988 chr2:99655755 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs6540559 0.673 rs41305104 chr1:209950848 G/A cg25204440 chr1:209979598 IRF6 0.59 5.8 0.34 1.9e-8 Cleft lip with or without cleft palate; CESC cis rs13031619 0.605 rs4849972 chr2:3698846 C/A cg10645314 chr2:3704589 ALLC 0.53 5.18 0.3 4.46e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs6582630 0.562 rs35080195 chr12:38310866 G/A cg26384229 chr12:38710491 ALG10B -0.45 -5.83 -0.34 1.64e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9303401 0.614 rs28687626 chr17:57191904 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.99 11.34 0.57 1.49e-24 Cognitive test performance; CESC cis rs1538970 0.961 rs4660854 chr1:45854087 A/T cg06784218 chr1:46089804 CCDC17 0.31 5.33 0.31 2.13e-7 Platelet count; CESC cis rs7224314 1.000 rs7224314 chr17:65386214 A/C cg01507342 chr17:65387096 PITPNC1 -0.49 -5.91 -0.34 1.05e-8 Diisocyanate-induced asthma; CESC cis rs5769765 0.671 rs138833 chr22:50178917 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.47 -5.26 -0.31 2.98e-7 Schizophrenia; CESC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs9611565 0.649 rs5758466 chr22:42176059 G/A cg03806693 chr22:41940476 POLR3H 0.79 9.47 0.5 1.59e-18 Vitiligo; CESC cis rs2425143 0.915 rs6060597 chr20:34370100 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.8 7.75 0.43 1.96e-13 Blood protein levels; CESC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg02569458 chr12:86230093 RASSF9 0.5 7.74 0.43 2.06e-13 Major depressive disorder; CESC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg04414720 chr1:150670196 GOLPH3L -0.37 -5.26 -0.31 3.03e-7 Tonsillectomy; CESC cis rs1348850 0.757 rs4893969 chr2:178478476 T/A cg22681709 chr2:178499509 PDE11A -0.42 -6.35 -0.36 9.34e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg19717773 chr7:2847554 GNA12 -0.56 -8.27 -0.45 6.44e-15 Height; CESC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg08736216 chr1:53307985 ZYG11A 0.4 6.48 0.37 4.57e-10 Monocyte count; CESC cis rs1559088 0.947 rs7256182 chr19:33558591 G/A cg17764715 chr19:33622953 WDR88 0.46 5.66 0.33 3.86e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs8012 0.537 rs741702 chr19:13024250 A/C cg23899408 chr19:12877188 HOOK2 0.43 5.17 0.3 4.71e-7 Mean corpuscular hemoglobin;Mean corpuscular volume;Blood metabolite levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19374457 chr1:44412380 IPO13 -0.4 -6.21 -0.36 2.02e-9 Gambling; CESC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg13206674 chr6:150067644 NUP43 0.43 6.18 0.35 2.39e-9 Lung cancer; CESC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg11494091 chr17:61959527 GH2 0.71 11.9 0.59 1.84e-26 Prudent dietary pattern; CESC cis rs796364 0.951 rs11680258 chr2:200996976 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -6.26 -0.36 1.57e-9 Schizophrenia; CESC cis rs1801251 1.000 rs10933412 chr2:233707226 G/C cg08000102 chr2:233561755 GIGYF2 -0.69 -9.93 -0.52 5.71e-20 Coronary artery disease; CESC cis rs2011503 1.000 rs8110171 chr19:19560063 C/T cg11584989 chr19:19387371 SF4 0.62 7.22 0.41 5.51e-12 Bipolar disorder; CESC cis rs17490626 0.568 rs12413523 chr10:71211664 C/G cg12610070 chr10:71211762 TSPAN15 -0.32 -6.91 -0.39 3.55e-11 Thrombosis; CESC cis rs6732160 0.613 rs62151837 chr2:73390396 G/T cg01422370 chr2:73384389 NA 0.56 9.02 0.48 3.8e-17 Intelligence (multi-trait analysis); CESC trans rs1218282 0.655 rs17771893 chr13:79466495 C/T cg07274194 chr6:43423442 DLK2 0.74 6.24 0.36 1.69e-9 Response to statin therapy; CESC trans rs11098499 0.954 rs878373 chr4:120237484 A/T cg25214090 chr10:38739885 LOC399744 0.69 9.59 0.51 6.82e-19 Corneal astigmatism; CESC cis rs2014572 0.967 rs7259978 chr19:57756129 C/T cg12963866 chr19:57752005 ZNF805 -0.49 -6.53 -0.37 3.32e-10 Hyperactive-impulsive symptoms; CESC trans rs208520 0.690 rs10455194 chr6:66743356 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 12.2 0.6 1.84e-27 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13648682 chr9:136933664 BRD3 0.51 6.17 0.35 2.57e-9 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg19193384 chr17:30244184 NA -0.68 -6.12 -0.35 3.42e-9 Hip circumference adjusted for BMI; CESC cis rs72781680 0.898 rs72790310 chr2:24116716 C/T cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs1801251 1.000 rs4973053 chr2:233670099 G/A cg25237894 chr2:233734115 C2orf82 -0.46 -8.17 -0.45 1.27e-14 Coronary artery disease; CESC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg16325326 chr1:53192061 ZYG11B 0.9 14.85 0.67 1.06e-36 Monocyte count; CESC cis rs6500395 1.000 rs4785535 chr16:48707659 A/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs739401 0.967 rs451041 chr11:3060725 C/T cg25174290 chr11:3078921 CARS 0.48 6.75 0.38 9.5e-11 Longevity; CESC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg26939375 chr7:64535504 NA 0.76 10.8 0.55 8.95e-23 Calcium levels; CESC cis rs2243480 1.000 rs2420171 chr7:65637760 T/C cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.25e-32 Diabetic kidney disease; CESC cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg12927641 chr6:109611667 NA 0.44 6.87 0.39 4.65e-11 Reticulocyte fraction of red cells; CESC cis rs7592578 0.679 rs59929070 chr2:191327852 A/G cg10560079 chr2:191398806 TMEM194B -0.6 -5.84 -0.34 1.56e-8 Diastolic blood pressure; CESC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg10691866 chr7:65817282 TPST1 0.31 5.18 0.3 4.5e-7 Aortic root size; CESC cis rs2066819 1.000 rs78495928 chr12:56635080 G/C cg26714650 chr12:56694279 CS -1.42 -10.04 -0.53 2.52e-20 Psoriasis vulgaris; CESC cis rs36051895 0.623 rs57707737 chr9:5062844 A/T cg02405213 chr9:5042618 JAK2 -0.49 -5.94 -0.34 8.82e-9 Pediatric autoimmune diseases; CESC cis rs62244186 0.545 rs725866 chr3:44765533 A/G cg15225532 chr3:44803084 KIF15;KIAA1143 0.48 6.18 0.35 2.43e-9 Depressive symptoms; CESC cis rs4727963 0.840 rs1464876 chr7:122729235 C/G cg03640110 chr7:122635026 TAS2R16 -0.37 -5.6 -0.33 5.48e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs7824557 0.527 rs2736296 chr8:11234844 G/A cg21775007 chr8:11205619 TDH -0.54 -8.08 -0.44 2.33e-14 Retinal vascular caliber; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06077405 chr7:2313805 SNX8 -0.57 -6.54 -0.37 3.11e-10 Gut microbiome composition (summer); CESC cis rs644799 0.509 rs580181 chr11:95643040 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.55 7.29 0.41 3.58e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1707322 0.721 rs11211158 chr1:46132850 C/G cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11031096 0.678 rs11031220 chr11:4197638 G/A cg18678763 chr11:4115507 RRM1 -0.4 -5.18 -0.3 4.46e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs2404602 0.622 rs11632670 chr15:76974055 A/G cg23625390 chr15:77176239 SCAPER -0.46 -6.32 -0.36 1.12e-9 Blood metabolite levels; CESC cis rs4481887 1.000 rs4508046 chr1:248488988 T/C cg00666640 chr1:248458726 OR2T12 0.41 6.74 0.38 9.64e-11 Common traits (Other); CESC cis rs9916302 0.904 rs12452509 chr17:37574722 G/A cg15445000 chr17:37608096 MED1 0.41 6.74 0.38 9.67e-11 Glomerular filtration rate (creatinine); CESC cis rs9394152 0.845 rs7747216 chr6:33476718 A/G cg13560919 chr6:33536144 NA -0.47 -7.27 -0.41 4.05e-12 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs959260 1.000 rs2033609 chr17:73367021 C/T cg12999837 chr17:73267436 MIF4GD -0.47 -5.46 -0.32 1.1e-7 Systemic lupus erythematosus; CESC cis rs11785400 1.000 rs4736365 chr8:143742197 A/G cg10596483 chr8:143751796 JRK 0.43 5.63 0.33 4.56e-8 Schizophrenia; CESC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg04398451 chr17:18023971 MYO15A -0.65 -9.27 -0.49 6.65e-18 Total body bone mineral density; CESC cis rs992157 0.835 rs12987219 chr2:219144149 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.68 -8.81 -0.48 1.66e-16 Colorectal cancer; CESC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg18240062 chr17:79603768 NPLOC4 0.54 7.12 0.4 1.04e-11 Eye color traits; CESC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg12311346 chr5:56204834 C5orf35 -0.73 -8.78 -0.47 2.14e-16 Initial pursuit acceleration; CESC cis rs12681288 0.550 rs4637864 chr8:959761 C/T cg04851639 chr8:1020857 NA -0.28 -5.59 -0.32 5.55e-8 Schizophrenia; CESC cis rs6087990 0.735 rs2424907 chr20:31359819 C/T cg13636640 chr20:31349939 DNMT3B 0.79 12.88 0.62 8.47e-30 Ulcerative colitis; CESC cis rs7312933 0.558 rs1796382 chr12:42840955 C/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.5 -6.6 -0.38 2.29e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs10927875 0.688 rs2009371 chr1:16348083 A/T cg22431228 chr1:16359049 CLCNKA -0.51 -8.37 -0.46 3.39e-15 Dilated cardiomyopathy; CESC cis rs79387448 0.638 rs6759588 chr2:103040159 A/G cg09003973 chr2:102972529 NA 1.18 8.9 0.48 9.32e-17 Gut microbiota (bacterial taxa); CESC cis rs6582630 0.555 rs34730221 chr12:38405140 C/T cg26384229 chr12:38710491 ALG10B -0.66 -9.89 -0.52 7.72e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.64 0.33 4.45e-8 Menopause (age at onset); CESC cis rs1707322 1.000 rs11211222 chr1:46367757 T/C cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2346177 0.554 rs34854267 chr2:46708542 T/C cg02822958 chr2:46747628 ATP6V1E2 0.44 5.47 0.32 1.02e-7 HDL cholesterol; CESC cis rs55728055 0.661 rs62237796 chr22:31976578 T/G cg01338084 chr22:32026380 PISD 1.22 8.02 0.44 3.48e-14 Age-related hearing impairment; CESC cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg12927641 chr6:109611667 NA -0.44 -6.78 -0.38 7.73e-11 Reticulocyte fraction of red cells; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg05409276 chr17:73400549 GRB2 0.47 6.03 0.35 5.53e-9 Attention deficit hyperactivity disorder; CESC cis rs2832077 0.943 rs2832084 chr21:30154798 A/G cg03476357 chr21:30257390 N6AMT1 -0.49 -5.2 -0.3 3.91e-7 Cognitive test performance; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23115219 chr1:150459717 TARS2 0.6 6.76 0.38 8.76e-11 Gut microbiome composition (summer); CESC cis rs1580019 0.563 rs10486509 chr7:32585443 C/G cg06627557 chr7:32535165 LSM5;AVL9 -1.07 -18.17 -0.74 1.83e-48 Cognitive ability; CESC cis rs5753618 0.583 rs5753615 chr22:31828027 T/C cg00478049 chr22:31556069 RNF185 -0.43 -5.12 -0.3 5.75e-7 Colorectal cancer; CESC cis rs72945132 0.607 rs67767222 chr11:70121610 T/A cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs9581857 0.685 rs11839899 chr13:28041780 G/A cg01674679 chr13:27998804 GTF3A -0.69 -5.52 -0.32 8.1e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg21548813 chr6:291882 DUSP22 -0.75 -10.21 -0.53 7.25e-21 Menopause (age at onset); CESC trans rs12681287 0.547 rs4961197 chr8:87512436 T/C cg27317242 chr8:23145699 R3HCC1 -0.53 -6.34 -0.36 9.67e-10 Caudate activity during reward; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03066081 chr17:77784036 NA 0.47 6.08 0.35 4.28e-9 Gut microbiota (bacterial taxa); CESC cis rs9457247 0.646 rs4710160 chr6:167409241 T/A cg07741184 chr6:167504864 NA 0.3 5.52 0.32 8.06e-8 Crohn's disease; CESC cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9430161 0.579 rs6696575 chr1:11037136 G/A cg02454025 chr1:11042201 C1orf127 0.93 14.49 0.66 1.93e-35 Ewing sarcoma; CESC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg24549020 chr5:56110836 MAP3K1 0.65 7.56 0.42 6.72e-13 Initial pursuit acceleration; CESC cis rs7264396 0.676 rs6058383 chr20:34556005 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.35 -0.54 2.7e-21 Total cholesterol levels; CESC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg21963583 chr11:68658836 MRPL21 0.4 5.52 0.32 8.06e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs909341 0.710 rs2297433 chr20:62293460 T/C cg03999872 chr20:62272968 STMN3 0.56 5.43 0.32 1.27e-7 Atopic dermatitis; CESC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg00310523 chr12:86230176 RASSF9 0.35 5.61 0.33 5.01e-8 Major depressive disorder; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg15459695 chr2:236403016 AGAP1 -0.48 -6.62 -0.38 2.02e-10 Recombination measurement; CESC cis rs9300255 0.510 rs1790133 chr12:123698518 T/G cg00376283 chr12:123451042 ABCB9 0.71 8.97 0.48 5.68e-17 Neutrophil percentage of white cells; CESC cis rs4891159 0.790 rs7241485 chr18:74122325 C/T cg24786174 chr18:74118243 ZNF516 -0.72 -11.28 -0.57 2.31e-24 Longevity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22515636 chr2:109150313 NA 0.49 6.29 0.36 1.28e-9 Gut microbiota (bacterial taxa); CESC trans rs35110281 0.592 rs6417729 chr21:44967202 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 7.91 0.44 6.95e-14 Mean corpuscular volume; CESC cis rs6831352 1.000 rs6822348 chr4:100053894 A/T cg21548116 chr4:100009993 ADH5 0.48 5.08 0.3 7.18e-7 Alcohol dependence; CESC cis rs7474896 0.561 rs2474603 chr10:38445682 C/T cg25427524 chr10:38739819 LOC399744 -0.52 -5.11 -0.3 6.12e-7 Obesity (extreme); CESC cis rs752010 0.644 rs7541348 chr1:42113215 T/G cg06885757 chr1:42089581 HIVEP3 0.5 8.0 0.44 3.85e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg01988459 chr11:68622903 NA -0.44 -5.96 -0.34 8.1e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg08470875 chr2:26401718 FAM59B 0.55 5.12 0.3 6.02e-7 Gut microbiome composition (summer); CESC trans rs11098499 0.588 rs2389874 chr4:120554991 A/G cg25214090 chr10:38739885 LOC399744 -0.54 -7.62 -0.42 4.53e-13 Corneal astigmatism; CESC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg00750074 chr16:89608354 SPG7 -0.42 -6.26 -0.36 1.55e-9 Multiple myeloma (IgH translocation); CESC cis rs734999 0.545 rs10797441 chr1:2551660 T/G cg20673091 chr1:2541236 MMEL1 0.48 8.03 0.44 3.11e-14 Ulcerative colitis; CESC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg22433210 chr17:43662623 NA 0.97 10.98 0.56 2.25e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg01206211 chr2:36825736 FEZ2 -0.34 -5.88 -0.34 1.25e-8 Height; CESC cis rs1949733 0.675 rs2688219 chr4:8444631 T/C cg11789530 chr4:8429930 ACOX3 0.75 10.87 0.56 5.27e-23 Response to antineoplastic agents; CESC cis rs4148883 0.504 rs2000864 chr4:100123776 A/C cg13256891 chr4:100009986 ADH5 0.48 6.16 0.35 2.76e-9 Alcohol dependence; CESC cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg11752832 chr7:134001865 SLC35B4 0.54 7.01 0.4 1.96e-11 Mean platelet volume; CESC cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg12648201 chr2:27665141 KRTCAP3 -0.31 -5.56 -0.32 6.74e-8 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26104816 chr1:42922390 ZMYND12;PPCS 0.58 6.49 0.37 4.17e-10 Gut microbiome composition (summer); CESC cis rs2404602 0.669 rs12441484 chr15:77109875 G/A cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs6582630 0.638 rs12831496 chr12:38552604 G/A cg26384229 chr12:38710491 ALG10B -0.42 -5.67 -0.33 3.67e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs7539624 0.588 rs2186006 chr1:223901545 T/C cg10100437 chr1:223903862 CAPN2 0.43 5.54 0.32 7.26e-8 Schizophrenia; CESC cis rs4979906 1.000 rs11002244 chr10:79446207 T/C cg00983440 chr10:79422392 NA -0.48 -5.12 -0.3 5.86e-7 Mortality in heart failure; CESC cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg02773041 chr1:40204384 PPIE 0.53 7.59 0.42 5.32e-13 Blood protein levels; CESC cis rs7772486 0.875 rs2748485 chr6:146332421 T/C cg05347473 chr6:146136440 FBXO30 0.51 6.72 0.38 1.12e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9814567 0.896 rs6794258 chr3:134344505 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.67 -0.33 3.63e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.63 8.4 0.46 2.81e-15 Total body bone mineral density; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg22907277 chr7:1156413 C7orf50 0.44 6.41 0.37 6.75e-10 Longevity;Endometriosis; CESC cis rs12911832 1.000 rs12911961 chr15:58985867 C/T cg05156742 chr15:59063176 FAM63B 0.58 7.41 0.41 1.69e-12 Schizophrenia; CESC cis rs2274273 0.870 rs28716725 chr14:55816610 T/C cg04306507 chr14:55594613 LGALS3 0.32 6.31 0.36 1.19e-9 Protein biomarker; CESC cis rs3008870 0.755 rs2755251 chr1:67496425 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.58 7.57 0.42 6.16e-13 Lymphocyte percentage of white cells; CESC cis rs5769765 0.955 rs5769767 chr22:50276909 G/A cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs11098499 0.909 rs9759478 chr4:120367998 G/A cg24375607 chr4:120327624 NA 0.48 5.93 0.34 9.24e-9 Corneal astigmatism; CESC trans rs9929218 1.000 rs4783570 chr16:68806539 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -8.03 -0.44 3.1e-14 Colorectal cancer; CESC cis rs2070488 0.689 rs6809352 chr3:38544349 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.78 -12.67 -0.61 4.27e-29 Electrocardiographic conduction measures; CESC cis rs17023223 0.537 rs10923759 chr1:119692194 A/G cg05756136 chr1:119680316 WARS2 0.49 5.91 0.34 1.06e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs2066819 1.000 rs1802236 chr12:56679751 A/G cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg02352107 chr15:76603736 ETFA 0.45 6.04 0.35 5.3e-9 Bronchopulmonary dysplasia; CESC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg21782813 chr7:2030301 MAD1L1 0.45 6.45 0.37 5.4e-10 Bipolar disorder and schizophrenia; CESC trans rs7178375 1.000 rs1474382 chr15:31214649 A/G cg04373760 chr16:53404718 NA 0.53 6.88 0.39 4.35e-11 Hypertriglyceridemia; CESC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs10242455 0.764 rs2037497 chr7:99315904 G/A cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.08 10.67 0.55 2.41e-22 Platelet count; CESC cis rs7633857 0.532 rs9873705 chr3:160768818 A/T cg03342759 chr3:160939853 NMD3 -0.44 -5.85 -0.34 1.45e-8 Educational attainment (years of education); CESC cis rs9815354 0.812 rs10510729 chr3:41831998 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9467711 0.606 rs9393705 chr6:26361011 G/A cg14345882 chr6:26364793 BTN3A2 0.59 6.06 0.35 4.66e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7071206 0.947 rs4979905 chr10:79416367 C/T cg23888215 chr10:79422304 NA -0.52 -5.64 -0.33 4.3e-8 Bone mineral density; CESC cis rs754466 0.580 rs11002289 chr10:79532580 G/A cg17075019 chr10:79541650 NA -0.89 -13.8 -0.65 5.03e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11098499 0.863 rs3775845 chr4:120432447 T/C cg25214090 chr10:38739885 LOC399744 0.71 9.72 0.51 2.71e-19 Corneal astigmatism; CESC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg01988459 chr11:68622903 NA -0.39 -5.5 -0.32 8.79e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6977940 0.512 rs6461600 chr7:2816537 C/T cg19731401 chr7:2775893 GNA12 0.59 5.69 0.33 3.34e-8 White matter integrity; CESC cis rs6460942 0.524 rs6948366 chr7:12369905 A/G cg06484146 chr7:12443880 VWDE -0.55 -7.79 -0.43 1.56e-13 Coronary artery disease; CESC cis rs10876993 0.928 rs2169988 chr12:58071165 G/A cg18357645 chr12:58087776 OS9 0.63 10.45 0.54 1.28e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs35146811 0.806 rs1534310 chr7:99699169 A/T cg22906224 chr7:99728672 NA 0.43 5.03 0.3 8.85e-7 Coronary artery disease; CESC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg02018176 chr4:1364513 KIAA1530 0.46 6.47 0.37 4.84e-10 Longevity; CESC cis rs7927592 0.956 rs948315 chr11:68309140 T/C cg20283391 chr11:68216788 NA -0.51 -6.11 -0.35 3.48e-9 Total body bone mineral density; CESC cis rs7020830 0.867 rs1472169 chr9:37209396 C/T cg14294708 chr9:37120828 ZCCHC7 1.24 23.66 0.82 2.8e-67 Schizophrenia; CESC cis rs7635838 0.617 rs347590 chr3:11289561 G/A cg00170343 chr3:11313890 ATG7 0.58 8.56 0.47 9.36e-16 HDL cholesterol; CESC trans rs2727020 0.729 rs1917325 chr11:49370004 G/A cg15704280 chr7:45808275 SEPT13 -0.87 -14.54 -0.67 1.28e-35 Coronary artery disease; CESC cis rs9581857 0.685 rs78595793 chr13:28031881 C/T cg01674679 chr13:27998804 GTF3A -0.68 -5.42 -0.32 1.35e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs4835473 0.897 rs4835333 chr4:144624327 A/C cg25736465 chr4:144833511 NA -0.36 -5.53 -0.32 7.69e-8 Immature fraction of reticulocytes; CESC trans rs12479064 0.724 rs3087403 chr2:100058870 C/T cg20598333 chr11:3663511 ART5 0.5 6.09 0.35 4.03e-9 Chronic sinus infection; CESC cis rs977987 0.843 rs35737321 chr16:75439185 A/T cg03315344 chr16:75512273 CHST6 0.4 5.77 0.33 2.24e-8 Dupuytren's disease; CESC cis rs501120 1.000 rs573141 chr10:44758587 G/A cg09554077 chr10:44749378 NA 0.52 6.91 0.39 3.59e-11 Coronary artery disease;Coronary heart disease; CESC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 5.16 0.3 4.74e-7 LDL cholesterol;Cholesterol, total; CESC cis rs1062177 0.950 rs59580263 chr5:151269577 T/A cg00977110 chr5:151150581 G3BP1 0.62 6.42 0.37 6.18e-10 Preschool internalizing problems; CESC cis rs6546550 0.901 rs6750488 chr2:70146125 C/T cg02498382 chr2:70120550 SNRNP27 -0.41 -7.36 -0.41 2.35e-12 Prevalent atrial fibrillation; CESC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg13126279 chr21:47581558 C21orf56 0.48 6.53 0.37 3.3e-10 Testicular germ cell tumor; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26313233 chr2:114415511 NA -0.48 -6.04 -0.35 5.21e-9 Asthma; CESC cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg18876405 chr7:65276391 NA 0.63 8.43 0.46 2.23e-15 Aortic root size; CESC cis rs2832191 0.729 rs2832201 chr21:30499841 A/G cg08807101 chr21:30365312 RNF160 -0.84 -11.67 -0.58 1.12e-25 Dental caries; CESC cis rs34779708 0.966 rs4934536 chr10:35441169 A/G cg03585969 chr10:35415529 CREM 0.76 10.0 0.52 3.56e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg26335602 chr6:28129616 ZNF389 0.41 5.45 0.32 1.18e-7 Depression; CESC cis rs9399401 0.626 rs1928528 chr6:142779109 T/G cg03128060 chr6:142623767 GPR126 0.3 5.03 0.3 8.92e-7 Chronic obstructive pulmonary disease; CESC cis rs1865760 0.566 rs4529296 chr6:26083135 C/G cg16482183 chr6:26056742 HIST1H1C 0.38 5.11 0.3 6.19e-7 Height; CESC cis rs1559088 0.576 rs4805852 chr19:33609441 C/T cg03563238 chr19:33554763 RHPN2 -0.29 -5.35 -0.31 1.94e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs10242455 0.702 rs116671616 chr7:98954558 C/T cg25640893 chr7:99214727 ZNF498 0.85 5.73 0.33 2.69e-8 Blood metabolite levels; CESC cis rs113835537 0.529 rs4930379 chr11:66255674 G/A cg24851651 chr11:66362959 CCS 0.45 5.62 0.33 4.87e-8 Airway imaging phenotypes; CESC cis rs523522 0.962 rs10849757 chr12:120964014 G/A cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs4930103 1.000 rs4930103 chr11:2024544 G/A cg23202291 chr11:1979235 NA 0.4 6.03 0.35 5.48e-9 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs4319547 0.695 rs6489002 chr12:122929822 T/C cg05707623 chr12:122985044 ZCCHC8 -0.5 -5.78 -0.33 2.14e-8 Body mass index; CESC cis rs17407555 0.821 rs4533775 chr4:10141404 G/C cg11266682 chr4:10021025 SLC2A9 -0.49 -5.18 -0.3 4.33e-7 Schizophrenia (age at onset); CESC cis rs7927771 0.524 rs7942074 chr11:47720509 T/C cg18512352 chr11:47633146 NA 0.35 5.36 0.31 1.82e-7 Subjective well-being; CESC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg24250549 chr1:154909240 PMVK 0.74 10.98 0.56 2.38e-23 Prostate cancer; CESC cis rs11764590 0.724 rs1533829 chr7:2082841 A/G cg21782813 chr7:2030301 MAD1L1 -0.41 -5.68 -0.33 3.57e-8 Neuroticism; CESC cis rs1348850 0.668 rs6705405 chr2:178493713 A/G cg23306229 chr2:178417860 TTC30B 0.56 6.75 0.38 9.5e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg21573476 chr21:45109991 RRP1B -0.5 -6.86 -0.39 4.89e-11 Mean corpuscular volume; CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg21237687 chr17:6899380 ALOX12 0.5 8.64 0.47 5.34e-16 Tonsillectomy; CESC cis rs9300255 0.602 rs1727306 chr12:123665695 A/G cg19016782 chr12:123741754 C12orf65 -0.45 -6.21 -0.36 2.01e-9 Neutrophil percentage of white cells; CESC cis rs3820068 0.705 rs4646085 chr1:15825411 A/T cg18192808 chr1:15853278 DNAJC16 0.48 5.83 0.34 1.58e-8 Systolic blood pressure; CESC cis rs7296418 0.630 rs28419092 chr12:123812629 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.11 -0.3 6.23e-7 Platelet count; CESC cis rs634534 0.622 rs1308733 chr11:65720841 T/C cg17985854 chr11:65770987 BANF1;EIF1AD -0.44 -6.39 -0.37 7.53e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg19717773 chr7:2847554 GNA12 -0.65 -11.24 -0.57 3.1e-24 Height; CESC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -6.63 -0.38 1.92e-10 Bipolar disorder; CESC cis rs6866344 0.570 rs11740283 chr5:178136440 T/C cg10224037 chr5:178157518 ZNF354A 0.71 8.39 0.46 2.99e-15 Neutrophil percentage of white cells; CESC trans rs7615952 0.576 rs4646748 chr3:125826329 G/A cg07211511 chr3:129823064 LOC729375 -0.58 -6.44 -0.37 5.64e-10 Blood pressure (smoking interaction); CESC cis rs643506 1.000 rs1788955 chr11:111630998 C/G cg09085632 chr11:111637200 PPP2R1B 0.52 6.79 0.39 7.17e-11 Breast cancer; CESC cis rs7191439 0.674 rs4782430 chr16:88792047 A/G cg27087555 chr16:88793112 FAM38A -1.38 -13.51 -0.64 5.47e-32 Plateletcrit; CESC cis rs4843747 0.671 rs74729706 chr16:88104159 C/T cg03395651 chr16:88107091 BANP 0.46 5.34 0.31 2.01e-7 Menopause (age at onset); CESC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg08736216 chr1:53307985 ZYG11A -0.42 -7.0 -0.4 2.05e-11 Monocyte count; CESC cis rs72781680 1.000 rs72788278 chr2:24095285 A/C cg20701182 chr2:24300061 SF3B14 0.62 5.68 0.33 3.54e-8 Lymphocyte counts; CESC cis rs7216064 0.861 rs12449312 chr17:65829358 A/C cg07042672 chr17:66097459 LOC651250 -0.53 -5.9 -0.34 1.09e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11098499 0.738 rs72918577 chr4:120326701 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.97 0.52 4.42e-20 Corneal astigmatism; CESC cis rs10771431 0.817 rs10843149 chr12:9362067 G/A cg08997352 chr12:9597637 DDX12 -0.75 -10.16 -0.53 1.1e-20 Breast size; CESC trans rs724568 0.643 rs4671196 chr2:67927432 A/C cg19718508 chr5:176831858 F12 -0.45 -6.32 -0.36 1.12e-9 Major depressive disorder (broad); CESC cis rs2242194 0.816 rs6671688 chr1:154994265 T/C cg06221963 chr1:154839813 KCNN3 -0.38 -5.68 -0.33 3.51e-8 Schizophrenia; CESC cis rs9911578 0.933 rs2531726 chr17:56522533 C/T cg12560992 chr17:57184187 TRIM37 -0.91 -15.38 -0.69 1.41e-38 Intelligence (multi-trait analysis); CESC cis rs9660992 0.674 rs72745219 chr1:205262271 G/A cg21643547 chr1:205240462 TMCC2 -0.47 -6.25 -0.36 1.6e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs12900413 0.687 rs12913409 chr15:90319251 T/A cg24249390 chr15:90295951 MESP1 -0.42 -5.81 -0.34 1.78e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs9527 0.615 rs11191489 chr10:104740568 C/A cg04362960 chr10:104952993 NT5C2 0.42 5.2 0.3 4.06e-7 Arsenic metabolism; CESC cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg05347473 chr6:146136440 FBXO30 -0.53 -6.96 -0.39 2.69e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9911578 1.000 rs302854 chr17:56683612 G/A cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC cis rs637571 0.780 rs677029 chr11:65683531 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.62 7.9 0.44 7.51e-14 Eosinophil percentage of white cells; CESC cis rs1577917 1.000 rs12203924 chr6:86776412 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.01 -0.35 6.11e-9 Response to antipsychotic treatment; CESC cis rs7267979 1.000 rs7019 chr20:25278278 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.86 16.82 0.72 1.06e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs6429082 0.585 rs7524848 chr1:235711688 G/C cg26050004 chr1:235667680 B3GALNT2 -0.45 -5.03 -0.3 9.23e-7 Adiposity; CESC cis rs11608355 0.506 rs11066471 chr12:109828039 T/C cg19025524 chr12:109796872 NA -0.5 -6.34 -0.36 9.63e-10 Neuroticism; CESC cis rs2380220 0.516 rs7748108 chr6:96008082 T/C cg15832292 chr6:96025679 MANEA 0.65 7.31 0.41 3.09e-12 Behavioural disinhibition (generation interaction); CESC cis rs7089973 0.872 rs7918253 chr10:116614501 T/C cg23260525 chr10:116636907 FAM160B1 0.38 6.37 0.36 8.29e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4243830 0.737 rs925744 chr1:6615695 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.8 -7.85 -0.43 1.01e-13 Body mass index; CESC cis rs950169 0.881 rs72750843 chr15:85135783 C/T cg17507749 chr15:85114479 UBE2QP1 0.54 6.17 0.35 2.56e-9 Schizophrenia; CESC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg27211696 chr2:191398769 TMEM194B 0.49 7.29 0.41 3.51e-12 Pulse pressure; CESC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg26314531 chr2:26401878 FAM59B -0.62 -6.99 -0.39 2.29e-11 Gut microbiome composition (summer); CESC cis rs34638657 0.529 rs2059276 chr16:82223123 A/T cg09439754 chr16:82129088 HSD17B2 -0.29 -5.09 -0.3 6.69e-7 Lung adenocarcinoma; CESC cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg05340658 chr4:99064831 C4orf37 -0.8 -12.65 -0.61 5.04e-29 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.660 rs2320745 chr12:38239101 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.7 0.33 3.26e-8 Bladder cancer; CESC cis rs2228479 0.850 rs17233664 chr16:89810628 C/T cg00800038 chr16:89945340 TCF25 -0.88 -7.36 -0.41 2.3e-12 Skin colour saturation; CESC cis rs4423214 1.000 rs11233746 chr11:71171440 A/G cg05163923 chr11:71159392 DHCR7 0.88 11.67 0.58 1.18e-25 Vitamin D levels; CESC cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg21395723 chr22:39101663 GTPBP1 0.43 5.28 0.31 2.76e-7 Menopause (age at onset); CESC cis rs2228479 0.850 rs11648433 chr16:89965055 G/A cg06558623 chr16:89946397 TCF25 1.14 8.82 0.48 1.55e-16 Skin colour saturation; CESC cis rs4727027 0.835 rs6959224 chr7:148784495 A/G cg23158103 chr7:148848205 ZNF398 -0.39 -6.12 -0.35 3.28e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg13880726 chr7:1868755 MAD1L1 0.51 6.72 0.38 1.11e-10 Bipolar disorder and schizophrenia; CESC cis rs9913156 0.793 rs72835644 chr17:4573667 G/A cg19197139 chr17:4613644 ARRB2 0.95 10.62 0.55 3.4e-22 Lymphocyte counts; CESC cis rs12479064 0.694 rs4341989 chr2:100046783 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -7.13 -0.4 9.27e-12 Chronic sinus infection; CESC cis rs412050 0.501 rs2876980 chr22:22106535 C/T cg17089214 chr22:22089827 YPEL1 -0.66 -5.65 -0.33 4.24e-8 Attention deficit hyperactivity disorder; CESC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg21724239 chr8:58056113 NA 0.57 5.87 0.34 1.3e-8 Developmental language disorder (linguistic errors); CESC trans rs12681287 0.547 rs9942792 chr8:87509046 C/T cg27317242 chr8:23145699 R3HCC1 -0.53 -6.35 -0.36 9.05e-10 Caudate activity during reward; CESC cis rs1580019 0.562 rs4720064 chr7:32559638 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.06 19.17 0.76 5.81e-52 Cognitive ability; CESC cis rs17601876 0.778 rs4774584 chr15:51562007 G/A cg19946085 chr15:51559439 CYP19A1 -0.32 -5.12 -0.3 5.89e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs6430585 0.591 rs61187091 chr2:136468238 G/A cg07169764 chr2:136633963 MCM6 1.19 13.73 0.64 9.04e-33 Corneal structure; CESC cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg02935154 chr7:12443704 VWDE -0.53 -6.73 -0.38 1.07e-10 Coronary artery disease; CESC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg07092213 chr7:1199455 ZFAND2A -0.48 -5.11 -0.3 6.12e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17164693 chr10:124913828 BUB3 -0.51 -7.48 -0.42 1.13e-12 Gambling; CESC cis rs7089973 0.872 rs12773943 chr10:116631184 G/A cg23260525 chr10:116636907 FAM160B1 0.37 6.31 0.36 1.15e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7296418 0.518 rs28825193 chr12:123878262 T/C cg05973401 chr12:123451056 ABCB9 0.44 5.48 0.32 9.68e-8 Platelet count; CESC cis rs1670533 1.000 rs28562028 chr4:1055115 G/A cg27284194 chr4:1044797 NA 0.48 6.06 0.35 4.7e-9 Recombination rate (females); CESC cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg13298116 chr11:62369859 EML3;MTA2 0.5 7.81 0.43 1.32e-13 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg11494091 chr17:61959527 GH2 0.73 12.53 0.61 1.31e-28 Prudent dietary pattern; CESC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg08499158 chr17:42289980 UBTF -0.56 -7.32 -0.41 2.94e-12 Total body bone mineral density; CESC trans rs9354308 0.933 rs2802063 chr6:66564148 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 7.85 0.43 1.02e-13 Metabolite levels; CESC cis rs16866061 1.000 rs11686590 chr2:225334070 A/G cg12698349 chr2:225449008 CUL3 0.71 10.56 0.54 5.29e-22 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs9399135 0.967 rs4896125 chr6:135342569 C/T cg22676075 chr6:135203613 NA 0.51 7.36 0.41 2.34e-12 Red blood cell count; CESC cis rs9948 0.786 rs62156233 chr2:97434061 C/G cg01990225 chr2:97406019 LMAN2L -0.86 -7.56 -0.42 6.72e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs977987 0.800 rs12935787 chr16:75332335 C/T cg03315344 chr16:75512273 CHST6 0.38 5.47 0.32 1.06e-7 Dupuytren's disease; CESC cis rs546131 0.928 rs535719 chr11:34853382 A/G cg06937548 chr11:34938143 PDHX;APIP 0.54 6.88 0.39 4.21e-11 Lung disease severity in cystic fibrosis; CESC cis rs3820928 0.874 rs7594505 chr2:227878562 C/G cg05526886 chr2:227700861 RHBDD1 -0.45 -5.6 -0.33 5.33e-8 Pulmonary function; CESC cis rs6504663 1.000 rs6504661 chr17:48580126 A/T cg03611598 chr17:48586076 MYCBPAP -0.53 -6.96 -0.39 2.66e-11 Visceral fat; CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.32 -6.23 -0.36 1.83e-9 Electroencephalogram traits; CESC cis rs7843479 0.601 rs10866827 chr8:21801141 G/A cg17168535 chr8:21777572 XPO7 0.73 11.81 0.59 3.82e-26 Mean corpuscular volume; CESC cis rs6439153 0.743 rs71331685 chr3:128711425 T/A cg25356066 chr3:128598488 ACAD9 0.53 6.89 0.39 4.17e-11 Pneumococcal bacteremia; CESC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg23172400 chr8:95962367 TP53INP1 -0.5 -10.43 -0.54 1.43e-21 Type 2 diabetes; CESC cis rs8114671 0.836 rs734308 chr20:33572096 A/G cg07148914 chr20:33460835 GGT7 -0.43 -5.5 -0.32 9.05e-8 Height; CESC cis rs9517313 0.897 rs4772087 chr13:99115041 A/G cg20750642 chr13:99100586 FARP1 -0.36 -5.79 -0.34 1.98e-8 Neuroticism; CESC cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.47 -7.86 -0.43 9.42e-14 Hemoglobin concentration; CESC cis rs4664308 0.810 rs62175552 chr2:160937220 T/G cg03641300 chr2:160917029 PLA2R1 -0.67 -9.84 -0.52 1.11e-19 Idiopathic membranous nephropathy; CESC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg18876405 chr7:65276391 NA 0.53 7.32 0.41 3.01e-12 Aortic root size; CESC cis rs36051895 0.632 rs11788963 chr9:5120157 C/A cg02405213 chr9:5042618 JAK2 -0.53 -6.36 -0.36 8.65e-10 Pediatric autoimmune diseases; CESC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.08 -0.53 2.01e-20 Alzheimer's disease; CESC cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg20503657 chr10:835505 NA 0.64 7.17 0.4 7.7e-12 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19977241 chr2:74692637 MOGS 0.56 6.05 0.35 4.86e-9 Gut microbiome composition (summer); CESC cis rs4704187 0.625 rs11947996 chr5:74545548 A/T cg03227963 chr5:74354835 NA 0.28 5.27 0.31 2.86e-7 Response to amphetamines; CESC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 13.28 0.63 3.38e-31 Platelet count; CESC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg24879335 chr3:133465180 TF 0.36 6.36 0.36 8.76e-10 Iron status biomarkers; CESC cis rs5763662 1.000 rs5753028 chr22:30556845 A/G cg21388335 chr22:29999516 NF2 -0.76 -5.22 -0.31 3.63e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs9611565 0.559 rs5758412 chr22:42080803 T/A cg06481639 chr22:41940642 POLR3H 0.57 5.74 0.33 2.58e-8 Vitiligo; CESC cis rs9815354 0.812 rs113772069 chr3:41933389 T/C cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg03676636 chr4:99064102 C4orf37 0.34 5.08 0.3 7.25e-7 Colonoscopy-negative controls vs population controls; CESC cis rs921968 0.565 rs3770220 chr2:219619550 C/T cg02176678 chr2:219576539 TTLL4 -0.44 -7.67 -0.43 3.29e-13 Mean corpuscular hemoglobin concentration; CESC cis rs317689 0.718 rs315122 chr12:69771073 G/T cg20891283 chr12:69753455 YEATS4 0.64 7.56 0.42 6.68e-13 Response to diuretic therapy; CESC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg23978390 chr7:1156363 C7orf50 0.65 6.39 0.37 7.5e-10 Bronchopulmonary dysplasia; CESC cis rs12765878 1.000 rs10883942 chr10:105651386 A/G cg24587175 chr10:105670608 OBFC1 0.33 5.61 0.33 5.02e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18604876 chr3:5164258 ARL8B 0.54 6.5 0.37 4.01e-10 Gut microbiome composition (summer); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg21409833 chr1:63062724 DOCK7;ANGPTL3 0.37 6.01 0.35 6.06e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25130390 chr15:65810150 DPP8 -0.46 -6.41 -0.37 6.69e-10 Fibrinogen levels; CESC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs11231629 1 rs11231629 chr11:63648573 C/T cg04362095 chr11:63592001 C11orf84 -0.41 -5.26 -0.31 2.93e-7 Schizophrenia; CESC cis rs9660992 0.573 rs1172139 chr1:205213962 G/A cg00857998 chr1:205179979 DSTYK 0.56 6.86 0.39 4.73e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg15052019 chr19:19431593 KIAA0892;SF4 -0.41 -5.2 -0.3 3.93e-7 Tonsillectomy; CESC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg25072359 chr17:41440525 NA 0.43 5.82 0.34 1.72e-8 Menopause (age at onset); CESC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg10792982 chr14:105748885 BRF1 0.42 5.55 0.32 6.75e-8 Mean platelet volume;Platelet distribution width; CESC cis rs4423214 0.879 rs1790324 chr11:71150520 A/C cg05163923 chr11:71159392 DHCR7 -0.62 -7.59 -0.42 5.42e-13 Vitamin D levels; CESC cis rs7647973 1.000 rs13096474 chr3:49443081 C/T cg06212747 chr3:49208901 KLHDC8B -0.61 -8.02 -0.44 3.43e-14 Menarche (age at onset); CESC cis rs1018836 0.651 rs2339175 chr8:91565805 A/T cg16814680 chr8:91681699 NA -0.73 -10.01 -0.52 3.27e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs16866061 1.000 rs11688397 chr2:225393173 C/T cg12698349 chr2:225449008 CUL3 0.75 11.61 0.58 1.89e-25 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs2273669 0.667 rs12153822 chr6:109315115 T/C cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs854765 0.583 rs8070722 chr17:17813562 C/T cg16928487 chr17:17741425 SREBF1 -0.56 -9.71 -0.51 2.83e-19 Total body bone mineral density; CESC cis rs6582630 0.519 rs4294627 chr12:38293982 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.91e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9486719 0.947 rs2472908 chr6:96875998 A/T cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs8103278 1.000 rs17571725 chr19:46290822 C/T cg12641515 chr19:46296257 DMWD -0.51 -5.83 -0.34 1.6e-8 Coronary artery disease; CESC cis rs9943753 0.508 rs7138357 chr12:109832303 A/G cg19025524 chr12:109796872 NA -0.47 -6.66 -0.38 1.61e-10 HDL cholesterol; CESC cis rs11190604 1.000 rs2295779 chr10:102296061 A/G cg07080220 chr10:102295463 HIF1AN 0.68 6.33 0.36 1.02e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg02034447 chr16:89574710 SPG7 0.46 5.67 0.33 3.77e-8 Multiple myeloma (IgH translocation); CESC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 11.48 0.58 4.99e-25 Platelet count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06975592 chr1:165796857 UCK2 -0.45 -6.34 -0.36 9.6e-10 Gambling; CESC cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg27398817 chr8:82754497 SNX16 -0.56 -6.59 -0.38 2.39e-10 Diastolic blood pressure; CESC cis rs6032067 0.777 rs34085254 chr20:43786170 T/G cg10761708 chr20:43804764 PI3 0.57 6.65 0.38 1.64e-10 Blood protein levels; CESC cis rs820218 0.926 rs820204 chr17:73639951 G/C cg01592526 chr17:73663357 RECQL5;SAP30BP 0.4 5.36 0.31 1.79e-7 Rotator cuff tears; CESC cis rs35146811 0.807 rs10228764 chr7:99608029 A/G cg13334819 chr7:99746414 C7orf59 -0.43 -5.12 -0.3 5.86e-7 Coronary artery disease; CESC cis rs9837602 0.935 rs17392948 chr3:99754498 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.45 5.85 0.34 1.48e-8 Breast cancer; CESC cis rs4409675 0.527 rs12067053 chr1:28227122 T/G cg23691781 chr1:28212827 C1orf38 0.28 5.53 0.32 7.57e-8 Corneal astigmatism; CESC cis rs2295359 1.000 rs12043240 chr1:67624304 C/T cg17031739 chr1:67600172 NA 0.4 5.23 0.31 3.44e-7 Psoriasis; CESC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg21433313 chr16:3507492 NAT15 -0.59 -6.54 -0.37 3.24e-10 Tuberculosis; CESC cis rs17166499 0.803 rs17166479 chr7:12915193 T/C cg12945054 chr7:12841881 NA 0.5 5.08 0.3 7.05e-7 Bipolar disorder and schizophrenia; CESC cis rs2439831 0.867 rs12443102 chr15:43932103 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 8.4 0.46 2.73e-15 Lung cancer in ever smokers; CESC cis rs941764 0.965 rs747159 chr14:91841030 A/C cg10511902 chr14:91842949 CCDC88C -0.53 -8.54 -0.46 1.08e-15 Breast cancer; CESC trans rs1728785 1.000 rs698716 chr16:68560296 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.62 7.2 0.4 6.15e-12 Ulcerative colitis; CESC cis rs1801251 0.752 rs2675966 chr2:233735543 T/C cg08000102 chr2:233561755 GIGYF2 -0.58 -7.8 -0.43 1.4e-13 Coronary artery disease; CESC cis rs6543140 0.964 rs6761350 chr2:103030776 A/G cg04239558 chr2:103089729 SLC9A4 0.45 5.76 0.33 2.28e-8 Blood protein levels; CESC cis rs7833986 0.501 rs2976038 chr8:57028864 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.57 7.28 0.41 3.83e-12 Height; CESC cis rs67072384 0.818 rs6592483 chr11:72463974 A/G cg04827223 chr11:72435913 ARAP1 -0.67 -6.09 -0.35 3.94e-9 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg26119090 chr2:26468346 HADHA;HADHB 0.81 8.68 0.47 4e-16 Gut microbiome composition (summer); CESC cis rs6942756 0.956 rs7792317 chr7:128963971 G/A cg02491457 chr7:128862824 NA -0.66 -8.95 -0.48 6.38e-17 White matter hyperintensity burden; CESC cis rs7605827 0.897 rs7425203 chr2:15697410 A/G cg19274914 chr2:15703543 NA 0.37 6.48 0.37 4.42e-10 Educational attainment (years of education); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04578738 chr17:34136331 TAF15 0.48 6.49 0.37 4.12e-10 Systemic lupus erythematosus; CESC cis rs7516138 1.000 rs4240896 chr1:9713500 A/G cg26573321 chr1:9711663 PIK3CD -0.6 -9.5 -0.5 1.31e-18 Monocyte count; CESC cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.88e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.21 0.81 1.96e-62 Prudent dietary pattern; CESC cis rs2777491 0.507 rs11854081 chr15:41646398 C/T cg02330683 chr15:41787940 ITPKA 0.41 5.03 0.3 9.07e-7 Ulcerative colitis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13577194 chr9:95378173 IPPK 0.49 6.05 0.35 5.05e-9 Ulcerative colitis; CESC trans rs11098499 0.954 rs12505469 chr4:120249585 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.87 0.52 8.97e-20 Corneal astigmatism; CESC cis rs9916302 0.904 rs10491128 chr17:37551988 G/A cg07936489 chr17:37558343 FBXL20 0.78 10.65 0.55 2.75e-22 Glomerular filtration rate (creatinine); CESC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg22920501 chr2:26401640 FAM59B 0.83 8.85 0.48 1.25e-16 Gut microbiome composition (summer); CESC cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.6 7.52 0.42 8.77e-13 Multiple sclerosis; CESC cis rs7607369 0.580 rs17573724 chr2:219652141 T/A cg02176678 chr2:219576539 TTLL4 -0.48 -8.58 -0.47 8.14e-16 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg22920501 chr2:26401640 FAM59B -0.7 -8.39 -0.46 2.85e-15 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20259401 chr15:66995639 SMAD6 0.56 6.32 0.36 1.09e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02116590 chr2:3207260 TSSC1 0.51 7.03 0.4 1.78e-11 Fibrinogen levels; CESC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.4 0.41 1.83e-12 Intelligence (multi-trait analysis); CESC cis rs5769765 1.000 rs2092982 chr22:50282204 C/A cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg18016565 chr1:150552671 MCL1 -0.34 -5.15 -0.3 4.99e-7 Tonsillectomy; CESC cis rs2477686 0.526 rs12042427 chr1:2398107 C/T cg07700843 chr1:2391317 NA -0.42 -6.95 -0.39 2.84e-11 Non-obstructive azoospermia; CESC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg09417038 chr21:47716443 C21orf57 -0.45 -6.38 -0.36 7.77e-10 Testicular germ cell tumor; CESC cis rs9457247 1.000 rs439553 chr6:167391212 A/G cg23791538 chr6:167370224 RNASET2 -0.58 -8.26 -0.45 7.22e-15 Crohn's disease; CESC cis rs6748734 1.000 rs11893118 chr2:241828308 C/G cg07537917 chr2:241836409 C2orf54 -0.25 -5.38 -0.31 1.64e-7 Urinary metabolites; CESC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg18876405 chr7:65276391 NA -0.53 -7.37 -0.41 2.19e-12 Aortic root size; CESC cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.72 10.11 0.53 1.52e-20 Eosinophil percentage of white cells; CESC cis rs9815354 0.812 rs73071212 chr3:41981856 C/A cg03022575 chr3:42003672 ULK4 0.67 5.95 0.34 8.63e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg22143856 chr6:28129313 ZNF389 0.49 6.22 0.36 1.9e-9 Depression; CESC cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg02574844 chr11:5959923 NA -0.42 -5.36 -0.31 1.83e-7 DNA methylation (variation); CESC cis rs7551222 0.752 rs4245737 chr1:204486242 A/G cg20240347 chr1:204465584 NA -0.28 -5.63 -0.33 4.7e-8 Schizophrenia; CESC cis rs7000551 0.505 rs13258195 chr8:22227271 A/G cg12081754 chr8:22256438 SLC39A14 -0.91 -11.74 -0.58 6.61e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs55823223 0.564 rs936391 chr17:73847799 A/G cg10935138 chr17:73851978 WBP2 -0.79 -9.83 -0.52 1.17e-19 Psoriasis; CESC cis rs11122272 0.735 rs2790876 chr1:231536033 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.73 -0.43 2.29e-13 Hemoglobin concentration; CESC cis rs17253792 0.822 rs17832365 chr14:56153531 C/G cg01858014 chr14:56050164 KTN1 -0.97 -7.59 -0.42 5.34e-13 Putamen volume; CESC cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg02297831 chr4:17616191 MED28 0.48 5.93 0.34 9.5e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs34779708 0.677 rs112355105 chr10:35550294 A/T cg04310649 chr10:35416472 CREM -0.46 -5.21 -0.3 3.75e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs17601876 0.814 rs35939475 chr15:51554710 C/A cg19946085 chr15:51559439 CYP19A1 -0.33 -5.28 -0.31 2.69e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs4722166 0.630 rs7781534 chr7:22778592 A/C cg26061582 chr7:22766209 IL6 0.51 5.55 0.32 6.82e-8 Lung cancer; CESC cis rs3785574 0.621 rs1051684 chr17:62006497 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.61 -7.78 -0.43 1.5700000000000001e-13 Height; CESC cis rs30380 0.632 rs26497 chr5:96138767 T/C cg16492584 chr5:96139282 ERAP1 -0.49 -6.59 -0.38 2.37e-10 Cerebrospinal fluid biomarker levels; CESC cis rs3859192 0.537 rs12309 chr17:38175462 C/T cg17467752 chr17:38218738 THRA -0.44 -5.8 -0.34 1.93e-8 White blood cell count; CESC cis rs1008375 0.932 rs11938710 chr4:17670664 G/C cg16339924 chr4:17578868 LAP3 -0.63 -7.36 -0.41 2.26e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg09388058 chr16:47494735 PHKB;ITFG1 0.47 6.03 0.35 5.39e-9 Bronchopulmonary dysplasia; CESC cis rs12950390 0.893 rs11079789 chr17:45849715 A/G cg00777063 chr17:45855553 NA -0.41 -6.12 -0.35 3.4e-9 IgG glycosylation; CESC cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg20503657 chr10:835505 NA 0.71 6.72 0.38 1.12e-10 Eosinophil percentage of granulocytes; CESC cis rs67257959 0.708 rs13343952 chr19:17197064 G/C cg16202187 chr19:17186497 HAUS8;MYO9B 0.45 5.4 0.31 1.52e-7 Selective IgA deficiency; CESC cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg20503657 chr10:835505 NA 0.83 8.5 0.46 1.4e-15 Eosinophil percentage of granulocytes; CESC cis rs10751667 0.666 rs7395402 chr11:950293 A/G cg20946044 chr11:1010712 AP2A2 0.4 5.59 0.32 5.65e-8 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02390588 chr12:53722253 SP7 -0.46 -6.0 -0.35 6.51e-9 Gut microbiome composition (summer); CESC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg12718519 chr1:2058417 PRKCZ -0.25 -5.53 -0.32 7.59e-8 Height; CESC cis rs78132593 0.723 rs34593358 chr1:150686633 A/T cg22823121 chr1:150693482 HORMAD1 -0.43 -5.33 -0.31 2.13e-7 High light scatter reticulocyte count; CESC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg11814155 chr7:99998594 ZCWPW1 0.53 5.14 0.3 5.31e-7 Platelet count; CESC cis rs9818758 0.607 rs34784192 chr3:49274823 G/T cg00383909 chr3:49044727 WDR6 0.75 5.99 0.35 6.72e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg12463550 chr7:65579703 CRCP -0.61 -7.62 -0.42 4.56e-13 Aortic root size; CESC cis rs1387259 0.931 rs11168474 chr12:48621384 A/C cg04545296 chr12:48745243 ZNF641 0.39 6.56 0.37 2.76e-10 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs9911578 1.000 rs4793950 chr17:56593111 T/C cg12560992 chr17:57184187 TRIM37 -0.93 -15.56 -0.69 3.26e-39 Intelligence (multi-trait analysis); CESC cis rs2637266 1.000 rs7098929 chr10:78361194 T/G cg18941641 chr10:78392320 NA 0.41 7.87 0.44 9.17e-14 Pulmonary function; CESC cis rs10463316 0.894 rs6891272 chr5:150762842 G/T cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00093900 chr1:204381012 PPP1R15B 0.46 6.68 0.38 1.44e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg17724175 chr1:150552817 MCL1 0.4 6.06 0.35 4.56e-9 Melanoma; CESC cis rs6598955 0.724 rs12754536 chr1:26639605 T/C cg04990556 chr1:26633338 UBXN11 -0.74 -10.4 -0.54 1.88e-21 Obesity-related traits; CESC cis rs7917772 0.565 rs1043450 chr10:104434209 A/G ch.10.2196322F chr10:104248062 ACTR1A 0.53 5.78 0.33 2.14e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs61931739 0.534 rs11052974 chr12:34029877 T/G cg26384229 chr12:38710491 ALG10B 0.59 8.27 0.45 6.34e-15 Morning vs. evening chronotype; CESC cis rs7223966 1.000 rs7223966 chr17:61893398 G/A cg11494091 chr17:61959527 GH2 0.38 5.19 0.3 4.25e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg08470875 chr2:26401718 FAM59B -0.74 -7.92 -0.44 6.42e-14 Gut microbiome composition (summer); CESC cis rs4835473 0.932 rs4835120 chr4:144903523 C/A cg25736465 chr4:144833511 NA 0.41 6.25 0.36 1.64e-9 Immature fraction of reticulocytes; CESC trans rs7615952 0.599 rs2279821 chr3:125734308 G/A cg07211511 chr3:129823064 LOC729375 -0.6 -6.74 -0.38 9.88e-11 Blood pressure (smoking interaction); CESC cis rs2576037 0.583 rs680018 chr18:44409167 T/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.33 5.29 0.31 2.63e-7 Personality dimensions; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24031277 chr7:33102336 NT5C3 -0.46 -6.02 -0.35 5.64e-9 Ulcerative colitis; CESC cis rs10899021 0.790 rs10899019 chr11:74335162 A/G cg25880958 chr11:74394337 NA -0.74 -7.95 -0.44 5.44e-14 Response to metformin (IC50); CESC cis rs9611565 0.559 rs1006407 chr22:41972032 T/C cg03806693 chr22:41940476 POLR3H -1.16 -13.02 -0.62 2.74e-30 Vitiligo; CESC cis rs727505 1.000 rs9655845 chr7:124513355 G/C cg23710748 chr7:124431027 NA -0.46 -7.26 -0.41 4.25e-12 Lewy body disease; CESC cis rs7818688 0.697 rs11783878 chr8:95979261 C/T cg16049864 chr8:95962084 TP53INP1 -0.55 -5.58 -0.32 6.03e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs4664304 0.900 rs62176692 chr2:160743463 C/T cg03641300 chr2:160917029 PLA2R1 -0.46 -6.56 -0.37 2.88e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg19748678 chr4:122722346 EXOSC9 0.79 9.99 0.52 3.82e-20 Type 2 diabetes; CESC cis rs826838 0.967 rs826856 chr12:39115434 G/A cg13010199 chr12:38710504 ALG10B -0.46 -6.44 -0.37 5.5e-10 Heart rate; CESC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.63 7.99 0.44 4.28e-14 Height; CESC cis rs7577696 0.512 rs212691 chr2:32438075 G/A cg02381751 chr2:32503542 YIPF4 0.46 5.16 0.3 4.77e-7 Inflammatory biomarkers; CESC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg03188948 chr7:1209495 NA 0.73 7.02 0.4 1.85e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9911578 0.835 rs1476596 chr17:56485358 C/T cg05425664 chr17:57184151 TRIM37 -0.45 -6.23 -0.36 1.83e-9 Intelligence (multi-trait analysis); CESC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg27535305 chr1:53392650 SCP2 0.35 6.14 0.35 3.05e-9 Monocyte count; CESC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Depression; CESC cis rs3733585 0.673 rs116046986 chr4:9957794 A/G cg00071950 chr4:10020882 SLC2A9 -0.71 -11.5 -0.58 4.32e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs5769765 0.671 rs138841 chr22:50181960 C/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.46 -5.14 -0.3 5.34e-7 Schizophrenia; CESC cis rs919433 0.680 rs7582536 chr2:198436103 C/T cg20885578 chr2:198174922 NA -0.4 -5.08 -0.3 7.2e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs765787 0.530 rs55771002 chr15:45541566 T/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs9457247 0.967 rs425039 chr6:167410527 C/T cg07741184 chr6:167504864 NA 0.3 5.52 0.32 8.06e-8 Crohn's disease; CESC cis rs35110281 0.744 rs230644 chr21:44917183 C/T cg04455712 chr21:45112962 RRP1B -0.36 -5.35 -0.31 1.89e-7 Mean corpuscular volume; CESC cis rs11252926 0.545 rs10466270 chr10:556129 A/G cg03684893 chr10:554711 DIP2C -0.44 -6.92 -0.39 3.4e-11 Psychosis in Alzheimer's disease; CESC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg03806693 chr22:41940476 POLR3H -1.26 -16.9 -0.72 5.59e-44 Vitiligo; CESC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg00934597 chr7:893267 UNC84A 0.53 5.41 0.32 1.43e-7 Cerebrospinal P-tau181p levels; CESC cis rs7772486 0.875 rs2748490 chr6:146329681 G/T cg23711669 chr6:146136114 FBXO30 0.75 10.74 0.55 1.4e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs2304069 0.817 rs216132 chr5:149431259 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.74 -9.35 -0.5 3.69e-18 HIV-1 control; CESC cis rs9906944 0.933 rs35051752 chr17:47089908 G/A cg09029085 chr17:47094198 IGF2BP1 0.26 5.14 0.3 5.4e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs6973256 0.605 rs12707114 chr7:133345207 C/G cg10665199 chr7:133106180 EXOC4 0.46 6.18 0.35 2.44e-9 Intelligence (multi-trait analysis); CESC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg20814179 chr4:940893 TMEM175 0.36 5.39 0.31 1.54e-7 Sjögren's syndrome; CESC cis rs9916302 0.904 rs4794813 chr17:37670994 A/T cg20243544 chr17:37824526 PNMT 0.48 5.94 0.34 8.96e-9 Glomerular filtration rate (creatinine); CESC cis rs2243480 1.000 rs3885839 chr7:65290403 G/T cg25894440 chr7:65020034 NA -0.64 -5.53 -0.32 7.69e-8 Diabetic kidney disease; CESC cis rs11048434 0.736 rs12823100 chr12:9108908 C/A cg23795048 chr12:9217529 LOC144571 0.35 5.35 0.31 1.9e-7 Sjögren's syndrome; CESC cis rs818427 0.865 rs1093611 chr5:112218476 A/T cg07820702 chr5:112228657 REEP5 0.41 5.36 0.31 1.84e-7 Total body bone mineral density; CESC cis rs2952156 0.920 rs732084 chr17:37834357 A/C cg20243544 chr17:37824526 PNMT 0.63 8.38 0.46 3.08e-15 Asthma; CESC cis rs6912958 0.712 rs2246113 chr6:88410050 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -5.13 -0.3 5.52e-7 Monocyte percentage of white cells; CESC cis rs10751667 0.580 rs11246363 chr11:971667 T/C cg11406765 chr11:980039 AP2A2 -0.36 -5.07 -0.3 7.42e-7 Alzheimer's disease (late onset); CESC cis rs60843830 1.000 rs7605824 chr2:280819 A/G cg00108164 chr2:264199 ACP1;SH3YL1 -0.8 -10.46 -0.54 1.16e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.9 0.34 1.11e-8 Colonoscopy-negative controls vs population controls; CESC cis rs5769765 0.773 rs138861 chr22:50202276 A/G cg02269571 chr22:50332266 NA -0.44 -5.52 -0.32 8.24e-8 Schizophrenia; CESC cis rs7274811 0.681 rs210074 chr20:31949756 A/T cg21523528 chr20:32077966 CBFA2T2 -0.46 -5.47 -0.32 1.04e-7 Height; CESC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg13770153 chr20:60521292 NA -0.4 -5.19 -0.3 4.14e-7 Body mass index; CESC cis rs3768617 0.510 rs3768618 chr1:183092491 C/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs10206020 0.885 rs13388254 chr2:1577209 A/G cg26248373 chr2:1572462 NA -0.59 -6.93 -0.39 3.22e-11 IgG glycosylation; CESC cis rs4664308 1.000 rs2175416 chr2:160904021 G/A cg03641300 chr2:160917029 PLA2R1 -0.67 -10.16 -0.53 1.05e-20 Idiopathic membranous nephropathy; CESC trans rs7615952 0.733 rs13314847 chr3:125644788 C/T cg07211511 chr3:129823064 LOC729375 -1.13 -15.5 -0.69 5.37e-39 Blood pressure (smoking interaction); CESC cis rs921968 0.541 rs12617603 chr2:219369288 A/G cg02176678 chr2:219576539 TTLL4 -0.55 -9.83 -0.52 1.17e-19 Mean corpuscular hemoglobin concentration; CESC cis rs9291683 0.551 rs2276961 chr4:10022981 C/T cg11266682 chr4:10021025 SLC2A9 0.71 14.78 0.67 1.77e-36 Bone mineral density; CESC cis rs12824058 0.831 rs4759450 chr12:130812732 G/A cg24838063 chr12:130822603 PIWIL1 0.61 8.41 0.46 2.59e-15 Menopause (age at onset); CESC cis rs8092503 1.000 rs12606265 chr18:52492470 T/C cg12377874 chr18:52495404 RAB27B 0.37 6.13 0.35 3.13e-9 Childhood body mass index; CESC cis rs9926296 0.643 rs12596429 chr16:89841374 T/C cg27121462 chr16:89883253 FANCA 0.54 6.76 0.38 8.55e-11 Vitiligo; CESC cis rs1182196 0.533 rs2527521 chr7:2904928 A/G cg19717773 chr7:2847554 GNA12 0.52 8.25 0.45 7.55e-15 Plateletcrit; CESC trans rs7837860 0.588 rs7821897 chr8:89330431 C/G cg04391754 chr17:18022714 MYO15A -0.5 -6.01 -0.35 6.16e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9916302 0.904 rs11078915 chr17:37715426 T/C cg07936489 chr17:37558343 FBXL20 -0.81 -11.66 -0.58 1.24e-25 Glomerular filtration rate (creatinine); CESC cis rs854765 0.547 rs12150369 chr17:17911014 G/A cg04398451 chr17:18023971 MYO15A -0.69 -10.33 -0.54 3.02e-21 Total body bone mineral density; CESC cis rs75477785 1.000 rs79384526 chr1:209988274 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg25036284 chr2:26402008 FAM59B -0.86 -9.28 -0.5 6.28e-18 Gut microbiome composition (summer); CESC cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg01570182 chr17:44337453 NA 0.82 9.7 0.51 3.02e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9796 0.553 rs2925343 chr15:41306493 T/C cg18705301 chr15:41695430 NDUFAF1 0.49 6.93 0.39 3.1e-11 Menopause (age at onset); CESC trans rs7937682 1.000 rs10789843 chr11:111576158 C/T cg18187862 chr3:45730750 SACM1L -0.57 -6.57 -0.37 2.59e-10 Primary sclerosing cholangitis; CESC cis rs977987 0.806 rs7185640 chr16:75394399 A/G cg03315344 chr16:75512273 CHST6 0.39 5.64 0.33 4.3e-8 Dupuytren's disease; CESC cis rs2479106 0.591 rs6415840 chr9:126415689 A/G cg16191174 chr9:126692580 DENND1A 0.41 5.72 0.33 2.89e-8 Polycystic ovary syndrome; CESC cis rs1499614 1.000 rs2707832 chr7:66136549 C/T cg12463550 chr7:65579703 CRCP 0.77 5.93 0.34 9.26e-9 Gout; CESC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.5 -0.37 4e-10 Bipolar disorder; CESC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg01238044 chr22:24384105 GSTT1 -0.44 -5.47 -0.32 1.02e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9287719 0.578 rs62127189 chr2:10761326 T/C cg00105475 chr2:10696890 NA 0.37 5.03 0.3 9.03e-7 Prostate cancer; CESC cis rs9583531 0.600 rs7986286 chr13:111357207 A/G cg24331049 chr13:111365604 ING1 0.73 10.7 0.55 1.9e-22 Coronary artery disease; CESC cis rs2120019 1.000 rs12324912 chr15:75361006 G/A cg09165964 chr15:75287851 SCAMP5 -0.74 -8.85 -0.48 1.3e-16 Blood trace element (Zn levels); CESC cis rs7523875 0.516 rs6682599 chr1:211522427 G/A cg25617285 chr1:211431773 RCOR3 0.39 5.44 0.32 1.22e-7 Mean corpuscular volume; CESC cis rs6076065 0.748 rs1016628 chr20:23398738 C/G cg11657817 chr20:23433608 CST11 -0.41 -6.29 -0.36 1.3e-9 Facial morphology (factor 15, philtrum width); CESC cis rs2072732 0.861 rs72629494 chr1:2951349 T/C cg03976712 chr1:2946727 NA 0.33 5.45 0.32 1.17e-7 Plateletcrit; CESC cis rs10911232 0.524 rs4487994 chr1:182982173 T/A ch.1.3577855R chr1:183094577 LAMC1 0.83 13.31 0.63 2.65e-31 Hypertriglyceridemia; CESC cis rs10779751 0.690 rs910661 chr1:11130116 C/A cg08854313 chr1:11322531 MTOR 0.76 10.26 0.53 4.97e-21 Body mass index; CESC cis rs9815354 0.680 rs73073242 chr3:42015335 G/A cg03022575 chr3:42003672 ULK4 0.74 6.64 0.38 1.79e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs8112211 0.834 rs4312417 chr19:38797189 A/G cg14299480 chr19:38876666 GGN -0.41 -5.69 -0.33 3.28e-8 Blood protein levels; CESC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg24399712 chr22:39784796 NA -0.84 -11.77 -0.59 5.08e-26 Intelligence (multi-trait analysis); CESC cis rs35110281 0.626 rs162368 chr21:44934767 G/A cg01579765 chr21:45077557 HSF2BP -0.49 -8.75 -0.47 2.54e-16 Mean corpuscular volume; CESC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg26354017 chr1:205819088 PM20D1 0.84 12.93 0.62 5.49e-30 Menarche (age at onset); CESC cis rs9811920 0.809 rs4928153 chr3:99808445 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -7.53 -0.42 8.23e-13 Axial length; CESC cis rs8028182 0.636 rs4545784 chr15:75755651 A/G cg20655648 chr15:75932815 IMP3 0.49 6.33 0.36 1.05e-9 Sudden cardiac arrest; CESC cis rs9457247 0.935 rs401260 chr6:167405888 T/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.54 -0.46 1.09e-15 Crohn's disease; CESC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg12463550 chr7:65579703 CRCP -0.56 -7.23 -0.41 5.19e-12 Aortic root size; CESC cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -7.5 -0.42 9.68e-13 Personality dimensions; CESC cis rs7953249 0.502 rs1169294 chr12:121426594 G/A cg02403541 chr12:121454288 C12orf43 0.63 8.23 0.45 8.41e-15 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg25036284 chr2:26402008 FAM59B -0.85 -10.07 -0.53 2.12e-20 Gut microbiome composition (summer); CESC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg00684032 chr4:1343700 KIAA1530 0.43 6.37 0.36 8.23e-10 Obesity-related traits; CESC cis rs2845885 0.793 rs57779243 chr11:63882363 G/T cg26318627 chr11:63887540 MACROD1 -0.46 -5.46 -0.32 1.1e-7 Body mass index; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04674357 chr15:31745729 NA -0.42 -6.13 -0.35 3.09e-9 Intelligence (multi-trait analysis); CESC cis rs7223966 1.000 rs8064261 chr17:61705212 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.64 0.38 1.8e-10 Hip circumference adjusted for BMI;Body mass index; CESC trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg15556689 chr8:8085844 FLJ10661 -0.53 -6.64 -0.38 1.75e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs11676348 0.818 rs1126579 chr2:219000734 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.08 -0.35 4.18e-9 Ulcerative colitis; CESC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.04e-11 Tonsillectomy; CESC cis rs12765878 1.000 rs11191848 chr10:105650837 T/C cg11005552 chr10:105648138 OBFC1 0.34 5.05 0.3 8.35e-7 Coronary artery disease; CESC cis rs17021463 0.643 rs6841656 chr4:95300532 A/G cg11021082 chr4:95130006 SMARCAD1 0.51 7.12 0.4 1.03e-11 Testicular germ cell tumor; CESC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.43 -6.04 -0.35 5.25e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 0.575 rs78075335 chr8:57997243 A/C cg24829409 chr8:58192753 C8orf71 -0.42 -5.5 -0.32 8.75e-8 Developmental language disorder (linguistic errors); CESC cis rs17209837 0.607 rs2072384 chr7:87082868 A/T cg00919237 chr7:87102261 ABCB4 -0.51 -6.58 -0.37 2.45e-10 Gallbladder cancer; CESC cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg24308560 chr3:49941425 MST1R 0.58 8.37 0.46 3.27e-15 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10501177 chr8:17435088 PDGFRL 0.44 6.08 0.35 4.15e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3740540 0.507 rs897292 chr10:126290035 A/G cg04949429 chr10:126290192 LHPP 0.39 5.49 0.32 9.29e-8 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs9325144 0.723 rs11169518 chr12:39177237 C/A cg26384229 chr12:38710491 ALG10B -0.52 -7.43 -0.42 1.46e-12 Morning vs. evening chronotype; CESC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 5.8 0.34 1.87e-8 Bipolar disorder; CESC cis rs8058578 1.000 rs8058578 chr16:30726248 C/T cg02466173 chr16:30829666 NA -0.46 -7.36 -0.41 2.28e-12 Multiple myeloma; CESC cis rs798766 0.779 rs55895920 chr4:1735930 C/T cg10756475 chr4:1757242 NA 0.47 6.1 0.35 3.81e-9 Bladder cancer;Urinary bladder cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10883266 chr13:100741297 PCCA -0.41 -6.25 -0.36 1.65e-9 Gambling; CESC cis rs3736485 0.873 rs12441759 chr15:51755033 C/A cg08986416 chr15:51914746 DMXL2 -0.41 -5.23 -0.31 3.37e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15163040 chr3:167813423 GOLIM4 0.53 6.03 0.35 5.63e-9 Gut microbiome composition (summer); CESC cis rs992157 0.698 rs6746089 chr2:219170377 A/G cg00012203 chr2:219082015 ARPC2 0.74 9.77 0.51 1.94e-19 Colorectal cancer; CESC cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg05585544 chr11:47624801 NA -0.48 -7.06 -0.4 1.47e-11 Subjective well-being; CESC cis rs2274273 0.901 rs10140801 chr14:55730404 C/T cg04306507 chr14:55594613 LGALS3 0.3 5.93 0.34 9.63e-9 Protein biomarker; CESC cis rs17253792 0.822 rs10129890 chr14:56040413 A/T cg24579896 chr14:56047964 C14orf33;KTN1 0.81 6.32 0.36 1.08e-9 Putamen volume; CESC cis rs11098499 0.863 rs11723090 chr4:120490592 T/C cg09307838 chr4:120376055 NA 0.91 12.59 0.61 8.49e-29 Corneal astigmatism; CESC cis rs12681288 0.676 rs7459467 chr8:999359 C/T cg04851639 chr8:1020857 NA -0.33 -7.03 -0.4 1.76e-11 Schizophrenia; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg22146484 chr8:57123862 CHCHD7;PLAG1 -0.47 -6.17 -0.35 2.58e-9 Height; CESC trans rs7246657 0.943 rs1373991 chr19:37838911 T/C cg24637308 chr11:6592297 DNHD1 0.53 6.17 0.35 2.55e-9 Coronary artery calcification; CESC cis rs9796 0.870 rs4923890 chr15:41258990 T/C cg18705301 chr15:41695430 NDUFAF1 0.4 6.03 0.35 5.36e-9 Menopause (age at onset); CESC cis rs733175 0.855 rs10022499 chr4:10006537 C/A cg11266682 chr4:10021025 SLC2A9 0.39 5.26 0.31 2.93e-7 Psychosis and Alzheimer's disease; CESC cis rs9487051 0.676 rs6568567 chr6:109596993 A/G cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC cis rs7084402 0.967 rs10763551 chr10:60273898 G/A cg07615347 chr10:60278583 BICC1 -0.58 -9.07 -0.49 2.75e-17 Refractive error; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20770540 chr3:123304003 PTPLB -0.47 -6.16 -0.35 2.68e-9 Fibrinogen levels; CESC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg00149659 chr3:10157352 C3orf10 0.71 8.45 0.46 2.01e-15 Alzheimer's disease; CESC cis rs4722166 0.630 rs12700390 chr7:22777129 G/T cg05265849 chr7:22767390 IL6 0.57 7.11 0.4 1.06e-11 Lung cancer; CESC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg22823121 chr1:150693482 HORMAD1 0.39 5.47 0.32 1.05e-7 Melanoma; CESC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 11.36 0.57 1.21e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg05313129 chr8:58192883 C8orf71 -0.53 -6.02 -0.35 5.63e-9 Developmental language disorder (linguistic errors); CESC cis rs17376456 0.877 rs17083455 chr5:93446380 A/C cg21475434 chr5:93447410 FAM172A 0.81 7.64 0.42 3.93e-13 Diabetic retinopathy; CESC trans rs1728785 1.000 rs3203684 chr16:68600440 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -7.67 -0.43 3.32e-13 Ulcerative colitis; CESC trans rs1814175 0.935 rs11040465 chr11:49689323 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -17.52 -0.73 3.71e-46 Height; CESC cis rs9649465 0.967 rs12537072 chr7:123377213 A/G cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.46e-7 Migraine; CESC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg21770322 chr7:97807741 LMTK2 0.55 8.18 0.45 1.16e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs3091242 0.933 rs28633797 chr1:25741629 C/A cg12412775 chr1:25698385 RHCE -0.3 -5.37 -0.31 1.7e-7 Erythrocyte sedimentation rate; CESC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg22105103 chr4:187893119 NA 0.45 6.61 0.38 2.05e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4474465 0.688 rs4277140 chr11:78285096 G/T cg27205649 chr11:78285834 NARS2 -0.48 -6.2 -0.36 2.21e-9 Alzheimer's disease (survival time); CESC cis rs6088590 0.561 rs6059934 chr20:33178324 G/T cg08999081 chr20:33150536 PIGU 0.7 12.48 0.61 1.97e-28 Coronary artery disease; CESC cis rs11638352 1.000 rs2733203 chr15:44415602 G/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs9467711 0.606 rs28360517 chr6:26602453 A/G cg14345882 chr6:26364793 BTN3A2 0.56 6.06 0.35 4.58e-9 Autism spectrum disorder or schizophrenia; CESC cis rs425277 1.000 rs55826501 chr1:2059143 G/A cg16545954 chr1:2118288 C1orf86 0.33 5.53 0.32 7.52e-8 Height; CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg24846343 chr22:24311635 DDTL 0.64 10.95 0.56 2.8e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.16 0.81 2.75e-62 Prudent dietary pattern; CESC cis rs4243830 0.850 rs7552196 chr1:6590502 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -8.27 -0.45 6.59e-15 Body mass index; CESC cis rs1448094 0.511 rs10735486 chr12:86154352 T/A cg02569458 chr12:86230093 RASSF9 -0.42 -6.46 -0.37 4.89e-10 Major depressive disorder; CESC trans rs561341 0.941 rs4525554 chr17:30312819 T/C cg20587970 chr11:113659929 NA -1.41 -18.23 -0.75 1.08e-48 Hip circumference adjusted for BMI; CESC cis rs6991838 0.584 rs7459944 chr8:66478275 T/C cg13398993 chr8:66546079 ARMC1 -0.44 -5.37 -0.31 1.75e-7 Intelligence (multi-trait analysis); CESC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 5.02e-9 Prudent dietary pattern; CESC cis rs763121 0.853 rs6001173 chr22:39015302 A/G cg06022373 chr22:39101656 GTPBP1 0.94 16.75 0.72 1.86e-43 Menopause (age at onset); CESC cis rs7944584 0.545 rs7118178 chr11:47659135 G/A cg03711944 chr11:47377212 SPI1 -0.34 -5.33 -0.31 2.09e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg10351095 chr21:47802916 PCNT 0.46 6.35 0.36 9.45e-10 Testicular germ cell tumor; CESC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.41e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs7726839 0.540 rs72705097 chr5:655067 G/A cg25482853 chr8:67687455 SGK3 0.92 9.68 0.51 3.5e-19 Obesity-related traits; CESC trans rs1728785 1.000 rs889561 chr16:68605741 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.71 8.47 0.46 1.69e-15 Ulcerative colitis; CESC cis rs6987853 0.966 rs2974349 chr8:42404040 A/G cg09913449 chr8:42400586 C8orf40 -0.4 -5.91 -0.34 1.08e-8 Mean corpuscular hemoglobin concentration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25810927 chr2:84686638 SUCLG1 0.51 6.77 0.38 8.09e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9399137 0.507 rs6923512 chr6:135335268 A/G cg24558204 chr6:135376177 HBS1L -0.7 -9.52 -0.5 1.12e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs9811920 0.570 rs1021102 chr3:99603780 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg07701084 chr6:150067640 NUP43 0.47 6.12 0.35 3.44e-9 Lung cancer; CESC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg23034840 chr1:205782522 SLC41A1 0.66 7.9 0.44 7.59e-14 Menarche (age at onset); CESC cis rs7818345 0.595 rs58551730 chr8:19316627 T/A cg11303988 chr8:19266685 CSGALNACT1 0.35 5.34 0.31 2.02e-7 Language performance in older adults (adjusted for episodic memory); CESC cis rs9611565 0.659 rs169361 chr22:41877989 A/G cg06481639 chr22:41940642 POLR3H 0.64 6.51 0.37 3.83e-10 Vitiligo; CESC cis rs116095464 0.558 rs10055993 chr5:264296 A/C cg22857025 chr5:266934 NA -1.32 -13.72 -0.64 9.72e-33 Breast cancer; CESC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg04287289 chr16:89883240 FANCA 0.88 14.67 0.67 4.58e-36 Vitiligo; CESC cis rs2439831 0.867 rs4075674 chr15:43650230 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.84 12.1 0.6 4.05e-27 Lung cancer in ever smokers; CESC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg10074409 chr1:209979377 IRF6 0.4 5.47 0.32 1.02e-7 Cleft lip with or without cleft palate; CESC cis rs1568889 0.838 rs716366 chr11:28121536 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 13.26 0.63 3.98e-31 Bipolar disorder; CESC cis rs2839186 0.814 rs13052376 chr21:47707403 G/C cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 7.02e-11 Testicular germ cell tumor; CESC cis rs7927771 0.965 rs17788930 chr11:47752775 A/G cg20307385 chr11:47447363 PSMC3 -0.5 -6.18 -0.35 2.41e-9 Subjective well-being; CESC cis rs4843747 0.708 rs11866437 chr16:88072279 A/G cg09044154 chr16:88155775 NA 0.44 5.27 0.31 2.87e-7 Menopause (age at onset); CESC cis rs3126085 0.935 rs11583524 chr1:152161657 T/C cg03465714 chr1:152285911 FLG 0.46 5.38 0.31 1.61e-7 Atopic dermatitis; CESC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg00149659 chr3:10157352 C3orf10 0.73 8.73 0.47 2.9e-16 Alzheimer's disease; CESC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC trans rs526821 0.574 rs11230156 chr11:55334809 A/G cg15704280 chr7:45808275 SEPT13 -0.51 -6.3 -0.36 1.2e-9 Pediatric bone mineral density (spine); CESC cis rs748404 0.560 rs2255663 chr15:43829008 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.52 -6.72 -0.38 1.1e-10 Lung cancer; CESC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.95 14.1 0.65 4.6e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1707322 0.963 rs11211229 chr1:46400517 A/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1559088 0.576 rs11084707 chr19:33612873 C/T cg17764715 chr19:33622953 WDR88 0.59 8.43 0.46 2.31e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4588572 0.643 rs10044028 chr5:77794750 C/T cg11547950 chr5:77652471 NA 0.43 5.48 0.32 1.01e-7 Triglycerides; CESC cis rs10979 0.964 rs9496682 chr6:143898805 A/G cg25407410 chr6:143891975 LOC285740 -0.6 -9.01 -0.48 4.13e-17 Hypospadias; CESC cis rs9611565 0.649 rs139540 chr22:42178040 C/T cg06481639 chr22:41940642 POLR3H -0.47 -5.36 -0.31 1.8e-7 Vitiligo; CESC cis rs2742234 0.614 rs3026750 chr10:43607756 G/A cg07801480 chr10:43725741 RASGEF1A 0.37 5.22 0.31 3.7e-7 Hirschsprung disease; CESC cis rs1538970 0.816 rs3790583 chr1:45956828 C/G cg03146154 chr1:46216737 IPP 0.49 5.57 0.32 6.31e-8 Platelet count; CESC cis rs7824557 0.628 rs11991153 chr8:11203107 A/T cg21775007 chr8:11205619 TDH 0.58 8.95 0.48 6.5e-17 Retinal vascular caliber; CESC cis rs7660520 0.524 rs4862100 chr4:183732709 G/T cg03209412 chr4:183728196 NA 0.58 5.16 0.3 4.83e-7 Pediatric autoimmune diseases; CESC cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg17427002 chr7:12443146 VWDE -0.48 -5.33 -0.31 2.06e-7 Coronary artery disease; CESC cis rs9660992 0.710 rs1172138 chr1:205246019 G/A cg00857998 chr1:205179979 DSTYK 0.47 5.41 0.32 1.41e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg12193833 chr17:30244370 NA -0.51 -5.75 -0.33 2.4e-8 Hip circumference adjusted for BMI; CESC cis rs9640161 0.673 rs34489187 chr7:150044379 G/A cg10018233 chr7:150070692 REPIN1 0.38 5.3 0.31 2.39e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs524281 0.954 rs549187 chr11:65898631 C/T cg14036092 chr11:66035641 RAB1B -0.52 -6.11 -0.35 3.61e-9 Electroencephalogram traits; CESC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg25036284 chr2:26402008 FAM59B -0.61 -7.08 -0.4 1.31e-11 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05980726 chr4:1138767 NA 0.45 6.17 0.35 2.6e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7998202 0.668 rs2774422 chr13:113352392 C/T cg02820901 chr13:113351484 ATP11A 0.63 5.85 0.34 1.41e-8 Glycated hemoglobin levels; CESC cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg26597838 chr10:835615 NA 0.87 9.15 0.49 1.55e-17 Eosinophil percentage of granulocytes; CESC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg07507251 chr3:52567010 NT5DC2 0.4 7.1 0.4 1.15e-11 Bipolar disorder; CESC cis rs9291683 0.588 rs34501273 chr4:9996996 C/T cg00071950 chr4:10020882 SLC2A9 0.82 15.01 0.68 2.81e-37 Bone mineral density; CESC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg09177884 chr7:1199841 ZFAND2A -0.48 -6.02 -0.35 5.87e-9 Longevity;Endometriosis; CESC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs9325144 0.555 rs6582607 chr12:38717678 T/C cg23762105 chr12:34175262 ALG10 0.49 6.24 0.36 1.76e-9 Morning vs. evening chronotype; CESC cis rs1211375 0.606 rs1203977 chr16:256278 A/C cg00126636 chr16:237282 NA 0.41 6.22 0.36 1.92e-9 Hematology traits;Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs6582630 0.555 rs11182202 chr12:38476451 C/G cg13010199 chr12:38710504 ALG10B 0.47 6.11 0.35 3.63e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs2070433 0.756 rs2839295 chr21:47917871 A/T cg12379764 chr21:47803548 PCNT 0.51 6.19 0.36 2.33e-9 Lymphocyte counts; CESC cis rs13095912 0.889 rs34765114 chr3:185335156 T/A cg11274856 chr3:185301563 NA 0.34 5.35 0.31 1.94e-7 Systolic blood pressure; CESC cis rs7208859 0.623 rs8082537 chr17:29015932 T/C cg14008862 chr17:28927542 LRRC37B2 0.59 5.1 0.3 6.35e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg03647317 chr4:187891568 NA -0.39 -5.8 -0.34 1.88e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg12963246 chr6:28129442 ZNF389 0.43 6.31 0.36 1.15e-9 Cardiac Troponin-T levels; CESC cis rs4689388 0.926 rs4689391 chr4:6280449 G/A cg14416269 chr4:6271139 WFS1 0.48 7.99 0.44 4.16e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7089973 0.604 rs7904188 chr10:116610271 G/C cg23260525 chr10:116636907 FAM160B1 0.4 7.2 0.4 6.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.08 -13.24 -0.63 4.53e-31 Gut microbiome composition (summer); CESC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -7.53 -0.42 7.94e-13 Developmental language disorder (linguistic errors); CESC cis rs3020736 0.519 rs5996116 chr22:42517492 G/A cg15557168 chr22:42548783 NA 0.45 6.51 0.37 3.78e-10 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26162020 chr7:48964031 CDC14C -0.55 -6.38 -0.36 7.98e-10 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs12089989 chr1:150715782 G/A cg13175981 chr1:150552382 MCL1 -0.4 -5.1 -0.3 6.53e-7 Tonsillectomy; CESC cis rs11191270 0.554 rs11191275 chr10:104142800 C/T cg15320455 chr10:103880129 LDB1 0.58 5.25 0.31 3.11e-7 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Depression; CESC cis rs4654899 0.965 rs61781115 chr1:21322860 C/T cg05370193 chr1:21551575 ECE1 0.41 6.3 0.36 1.21e-9 Superior frontal gyrus grey matter volume; CESC cis rs12530845 1.000 rs12540688 chr7:135329690 T/C cg23117316 chr7:135346802 PL-5283 -0.41 -5.29 -0.31 2.52e-7 Red blood cell traits; CESC cis rs6691722 0.503 rs6656485 chr1:24707685 A/G cg02336364 chr1:24764700 NIPAL3 0.32 6.58 0.37 2.56e-10 Response to interferon beta in multiple sclerosis; CESC cis rs9486719 1.000 rs13208422 chr6:96892119 C/T cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs9811920 0.809 rs793443 chr3:99573547 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.38 -5.09 -0.3 6.84e-7 Axial length; CESC cis rs9902453 0.967 rs4356528 chr17:28489670 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.74 0.43 2.08e-13 Coffee consumption (cups per day); CESC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg11764359 chr7:65958608 NA -0.72 -9.54 -0.51 1e-18 Aortic root size; CESC cis rs4891159 0.790 rs689885 chr18:74110563 T/G cg24786174 chr18:74118243 ZNF516 0.75 11.79 0.59 4.61e-26 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27331401 chr3:37035207 MLH1;EPM2AIP1 0.55 6.39 0.37 7.61e-10 Gut microbiome composition (summer); CESC cis rs55728055 0.661 rs16989760 chr22:31951808 A/G cg01338084 chr22:32026380 PISD 1.26 8.09 0.44 2.21e-14 Age-related hearing impairment; CESC cis rs9896933 0.623 rs77166830 chr17:80833525 T/C cg19500275 chr17:80737654 TBCD 0.62 5.88 0.34 1.23e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs7143963 0.666 rs8008502 chr14:103359492 G/A cg24154132 chr14:103367632 TRAF3 0.36 6.22 0.36 1.88e-9 Body mass index; CESC cis rs7107174 0.892 rs4291702 chr11:78001248 C/T cg02023728 chr11:77925099 USP35 0.42 6.22 0.36 1.88e-9 Testicular germ cell tumor; CESC cis rs4654899 0.644 rs6669077 chr1:21290520 A/C cg05370193 chr1:21551575 ECE1 0.36 5.4 0.31 1.49e-7 Superior frontal gyrus grey matter volume; CESC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg05564831 chr3:52568323 NT5DC2 0.43 6.94 0.39 3.05e-11 Electroencephalogram traits; CESC cis rs7552404 0.961 rs211710 chr1:76109038 G/A cg03433033 chr1:76189801 ACADM -0.6 -6.89 -0.39 4.03e-11 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18976797 chr7:56434617 NA -0.34 -6.2 -0.36 2.14e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03357160 chr6:42531879 UBR2 0.6 7.34 0.41 2.69e-12 Gut microbiome composition (summer); CESC cis rs9916302 0.718 rs10445306 chr17:37591422 A/G cg07936489 chr17:37558343 FBXL20 -0.8 -11.5 -0.58 4.29e-25 Glomerular filtration rate (creatinine); CESC cis rs67478160 0.571 rs1155751 chr14:104286547 C/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.58 0.55 4.57e-22 Schizophrenia; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg13647821 chr6:148852503 SASH1 0.41 6.12 0.35 3.31e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg18876405 chr7:65276391 NA -0.53 -7.29 -0.41 3.66e-12 Aortic root size; CESC cis rs36051895 0.623 rs6476956 chr9:5261238 A/G cg02405213 chr9:5042618 JAK2 -0.51 -6.28 -0.36 1.41e-9 Pediatric autoimmune diseases; CESC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.7 0.33 3.22e-8 Major depressive disorder; CESC cis rs12479064 0.671 rs4851207 chr2:100105775 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.42 -0.41 1.6e-12 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12184120 chr19:38188083 ZNF607 -0.45 -5.99 -0.35 6.67e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08886844 chr19:8373286 CD320 0.58 6.27 0.36 1.43e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01676552 chr8:146156633 ZNF16 -0.6 -6.59 -0.38 2.3e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs1125461 chr6:146417653 C/T cg23711669 chr6:146136114 FBXO30 0.84 12.04 0.59 6.45e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs300703 0.872 rs428697 chr2:213302 G/A cg21211680 chr2:198530 NA 0.98 8.48 0.46 1.64e-15 Blood protein levels; CESC cis rs9291683 0.551 rs2240720 chr4:10020480 C/T cg11266682 chr4:10021025 SLC2A9 0.72 14.84 0.67 1.1e-36 Bone mineral density; CESC cis rs8016982 0.634 rs1035948 chr14:81682392 C/T cg01989461 chr14:81687754 GTF2A1 0.74 11.59 0.58 2.12e-25 Schizophrenia; CESC cis rs2073300 1.000 rs34449811 chr20:23443771 T/C cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs10870270 0.956 rs7904594 chr10:133734671 C/T cg08754478 chr10:133766260 PPP2R2D -0.62 -8.06 -0.44 2.63e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs5769707 0.935 rs5770594 chr22:50018497 G/A cg20744362 chr22:50050164 C22orf34 0.46 8.08 0.44 2.23e-14 Monocyte count;Monocyte percentage of white cells; CESC cis rs864537 0.676 rs3108155 chr1:167422057 C/G cg09179987 chr1:167433047 CD247 0.5 7.56 0.42 6.54e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs17401966 0.894 rs11587309 chr1:10446596 G/T cg15208524 chr1:10270712 KIF1B 0.41 5.29 0.31 2.61e-7 Hepatocellular carcinoma; CESC cis rs11785400 1.000 rs6997771 chr8:143747752 T/G cg10596483 chr8:143751796 JRK 0.43 5.63 0.33 4.59e-8 Schizophrenia; CESC cis rs9649465 0.522 rs662705 chr7:123431594 A/C cg03229431 chr7:123269106 ASB15 0.4 5.52 0.32 8.08e-8 Migraine; CESC cis rs1506636 1.000 rs2215553 chr7:123318478 G/T cg03229431 chr7:123269106 ASB15 -0.51 -6.74 -0.38 9.6e-11 Plateletcrit;Platelet count; CESC cis rs2243480 1.000 rs2460422 chr7:65601505 C/T cg13147721 chr7:65941812 NA -0.98 -9.24 -0.49 8.33e-18 Diabetic kidney disease; CESC cis rs2880765 0.835 rs2170736 chr15:86043398 A/G cg19183879 chr15:85880815 NA -0.25 -5.18 -0.3 4.31e-7 Coronary artery disease; CESC cis rs7605827 0.930 rs10929366 chr2:15531754 C/T cg19274914 chr2:15703543 NA 0.35 6.36 0.36 8.62e-10 Educational attainment (years of education); CESC cis rs6541297 0.703 rs653523 chr1:230318402 C/T cg20703242 chr1:230279135 GALNT2 -0.44 -5.77 -0.33 2.27e-8 Coronary artery disease; CESC cis rs9868809 0.772 rs9841602 chr3:48713570 A/G cg07636037 chr3:49044803 WDR6 -0.56 -5.17 -0.3 4.72e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs2549003 1.000 rs6894655 chr5:131818649 T/C cg21138405 chr5:131827807 IRF1 0.54 9.25 0.49 8e-18 Asthma (sex interaction); CESC cis rs2637266 1.000 rs2395388 chr10:78357203 C/T cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs796364 0.806 rs11688194 chr2:200916239 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs6547741 1.000 rs1919126 chr2:27801418 C/A cg27432699 chr2:27873401 GPN1 0.5 7.01 0.4 2.01e-11 Oral cavity cancer; CESC cis rs1355223 1.000 rs11601923 chr11:34764354 C/G cg11058730 chr11:34937778 PDHX;APIP -0.46 -5.99 -0.35 6.91e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09166770 chr16:30941758 FBXL19 -0.61 -6.7 -0.38 1.25e-10 Gut microbiome composition (summer); CESC cis rs6701037 1.000 rs6681020 chr1:175125264 G/A cg00321850 chr1:175162397 KIAA0040 -0.42 -5.88 -0.34 1.22e-8 Alcohol dependence; CESC cis rs1008375 1.000 rs11737138 chr4:17657986 G/A cg16339924 chr4:17578868 LAP3 0.55 6.93 0.39 3.22e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4566357 0.615 rs2396445 chr2:227917726 C/G cg05526886 chr2:227700861 RHBDD1 -0.54 -6.89 -0.39 4.01e-11 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27583038 chr1:234735904 NA 0.59 6.42 0.37 6.41e-10 Gut microbiome composition (summer); CESC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg15320075 chr8:145703422 NA -0.41 -5.74 -0.33 2.55e-8 Age at first birth; CESC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg04267008 chr7:1944627 MAD1L1 -0.48 -5.52 -0.32 8.26e-8 Schizophrenia; CESC cis rs3809566 0.963 rs12148057 chr15:63331509 A/T cg05507819 chr15:63340323 TPM1 0.52 6.37 0.36 8.15e-10 Platelet count; CESC cis rs10206020 0.885 rs11886082 chr2:1576683 T/C cg26248373 chr2:1572462 NA -0.6 -6.73 -0.38 1.02e-10 IgG glycosylation; CESC trans rs4950322 0.515 rs11239954 chr1:146717699 C/T cg04954894 chr8:38089920 DDHD2 -0.51 -6.03 -0.35 5.49e-9 Protein quantitative trait loci; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23416307 chr4:858299 GAK -0.56 -6.03 -0.35 5.63e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg06634786 chr22:41940651 POLR3H 0.7 7.03 0.4 1.8e-11 Vitiligo; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19695842 chr20:19997930 NAA20 -0.49 -7.0 -0.4 2.14e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs561341 0.882 rs563539 chr17:30307958 A/G cg00745463 chr17:30367425 LRRC37B -0.64 -6.4 -0.37 7.07e-10 Hip circumference adjusted for BMI; CESC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.62 0.51 5.54e-19 Platelet count; CESC cis rs6736093 0.966 rs13027171 chr2:112686988 G/A cg12686935 chr2:112915763 FBLN7 -0.43 -5.56 -0.32 6.75e-8 Coronary artery disease; CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg07092213 chr7:1199455 ZFAND2A -0.48 -5.55 -0.32 7.08e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg11494091 chr17:61959527 GH2 0.71 12.04 0.59 6.33e-27 Prudent dietary pattern; CESC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg13114125 chr14:105738426 BRF1 -0.91 -11.41 -0.57 8.44e-25 Mean platelet volume;Platelet distribution width; CESC cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg00149659 chr3:10157352 C3orf10 0.7 8.38 0.46 3.2e-15 Alzheimer's disease; CESC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg24642844 chr7:1081250 C7orf50 -0.64 -8.34 -0.46 4.05e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7833986 0.501 rs2667978 chr8:56897951 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.56 6.88 0.39 4.32e-11 Height; CESC cis rs2204008 0.575 rs10444564 chr12:38043782 T/C cg26384229 chr12:38710491 ALG10B 0.75 10.72 0.55 1.61e-22 Bladder cancer; CESC cis rs11098499 0.955 rs13129661 chr4:120152909 C/G cg09307838 chr4:120376055 NA 0.87 11.39 0.57 1.02e-24 Corneal astigmatism; CESC cis rs765787 0.530 rs11636395 chr15:45535684 G/C cg24006582 chr15:45444508 DUOX1 -0.54 -6.63 -0.38 1.84e-10 Uric acid levels; CESC cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg01475735 chr3:40494733 NA 0.45 5.51 0.32 8.33e-8 Renal cell carcinoma; CESC trans rs12310956 0.532 rs7306007 chr12:33975209 C/G cg26384229 chr12:38710491 ALG10B 0.5 6.82 0.39 5.98e-11 Morning vs. evening chronotype; CESC cis rs9611565 0.546 rs739132 chr22:42123099 A/T cg06481639 chr22:41940642 POLR3H 0.59 5.91 0.34 1.07e-8 Vitiligo; CESC cis rs6540556 0.954 rs7548219 chr1:209936466 A/G cg23920097 chr1:209922102 NA -0.36 -5.35 -0.31 1.93e-7 Red blood cell count; CESC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg27266027 chr21:40555129 PSMG1 -0.44 -5.22 -0.31 3.55e-7 Cognitive function; CESC cis rs8002861 0.870 rs12865116 chr13:44440441 C/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.43 -5.45 -0.32 1.14e-7 Leprosy; CESC cis rs2361718 0.521 rs2361724 chr17:78099114 G/A cg20811857 chr17:78079795 GAA -0.43 -6.25 -0.36 1.63e-9 Yeast infection; CESC cis rs3892630 0.824 rs35700505 chr19:33325006 C/T cg22980127 chr19:33182716 NUDT19 1.03 11.5 0.58 4.17e-25 Red blood cell traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25951811 chr14:96858416 AK7 -0.44 -6.0 -0.35 6.46e-9 Fibrinogen levels; CESC cis rs9300255 0.739 rs4759417 chr12:123746510 C/T cg00376283 chr12:123451042 ABCB9 0.71 8.92 0.48 7.64e-17 Neutrophil percentage of white cells; CESC cis rs2522056 0.808 rs2706373 chr5:131804256 C/T cg24060327 chr5:131705240 SLC22A5 0.61 6.89 0.39 4.17e-11 Lymphocyte counts;Fibrinogen; CESC cis rs868036 1.000 rs6494694 chr15:68057142 A/C cg08079166 chr15:68083412 MAP2K5 -0.44 -6.83 -0.39 5.7e-11 Restless legs syndrome; CESC cis rs992157 0.835 rs2271543 chr2:219142491 C/T cg00012203 chr2:219082015 ARPC2 -0.76 -9.55 -0.51 9.45e-19 Colorectal cancer; CESC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg19257562 chr1:2043853 PRKCZ 0.41 6.53 0.37 3.33e-10 Height; CESC cis rs317689 0.718 rs645026 chr12:69757931 G/A cg14784868 chr12:69753453 YEATS4 0.64 7.46 0.42 1.21e-12 Response to diuretic therapy; CESC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.55 7.27 0.41 4.11e-12 Lymphocyte counts; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00450475 chr10:75118604 TTC18 -0.51 -6.15 -0.35 2.92e-9 Ulcerative colitis; CESC cis rs796364 1.000 rs281771 chr2:200812202 A/C cg23649088 chr2:200775458 C2orf69 -0.52 -5.33 -0.31 2.12e-7 Schizophrenia; CESC cis rs6460942 0.659 rs28366613 chr7:12512167 C/T cg20607287 chr7:12443886 VWDE -0.66 -7.1 -0.4 1.16e-11 Coronary artery disease; CESC cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.3 -0.31 2.42e-7 Total body bone mineral density; CESC cis rs2486288 0.554 rs1719235 chr15:45576108 A/G cg09092052 chr15:45571596 NA 0.47 5.65 0.33 4.16e-8 Glomerular filtration rate; CESC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.67 0.33 3.7e-8 Bipolar disorder; CESC cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg04450456 chr4:17643702 FAM184B 0.41 5.79 0.33 2.03e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1577917 1.000 rs12661204 chr6:86678586 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.29 -0.36 1.32e-9 Response to antipsychotic treatment; CESC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg11644478 chr21:40555479 PSMG1 1.01 16.79 0.72 1.35e-43 Cognitive function; CESC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg02071572 chr4:1403502 NA 0.39 5.64 0.33 4.28e-8 Longevity; CESC cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg17366294 chr4:99064904 C4orf37 0.57 7.86 0.43 9.47e-14 Colonoscopy-negative controls vs population controls; CESC cis rs2535633 0.631 rs2245424 chr3:53003021 G/C cg11645453 chr3:52864694 ITIH4 -0.28 -5.34 -0.31 1.95e-7 Body mass index; CESC cis rs6445797 0.632 rs2054988 chr3:56593170 G/A cg13792233 chr3:56591045 CCDC66 0.38 5.04 0.3 8.76e-7 Gastritis; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg09395855 chr10:120967408 GRK5 -0.48 -6.24 -0.36 1.73e-9 Recombination measurement; CESC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 10.52 0.54 7.52e-22 Platelet count; CESC cis rs1624802 1.000 rs1624802 chr12:130497472 C/T cg15444478 chr12:130494697 NA 0.27 5.34 0.31 2.04e-7 Obesity-related traits; CESC cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg06022373 chr22:39101656 GTPBP1 0.9 14.22 0.66 1.8e-34 Menopause (age at onset); CESC cis rs2573652 0.674 rs11630583 chr15:100543355 G/A cg09918751 chr15:100517450 ADAMTS17 -0.3 -5.57 -0.32 6.12e-8 Height; CESC cis rs763121 0.853 rs2413544 chr22:39059404 A/C cg06544989 chr22:39130855 UNC84B 0.49 8.49 0.46 1.53e-15 Menopause (age at onset); CESC cis rs9296736 0.890 rs1359561 chr6:53899341 C/T cg04374786 chr6:53939321 C6orf142 0.39 6.02 0.35 5.83e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs477895 1.000 rs477895 chr11:64048912 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.56 -5.62 -0.33 4.9e-8 Mean platelet volume; CESC cis rs6964587 0.869 rs406 chr7:91546526 C/A cg17063962 chr7:91808500 NA -0.52 -6.87 -0.39 4.7e-11 Breast cancer; CESC cis rs59918340 0.764 rs10107024 chr8:142227592 T/C cg23750338 chr8:142222470 SLC45A4 0.62 9.36 0.5 3.58e-18 Immature fraction of reticulocytes; CESC cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg03467027 chr4:99064603 C4orf37 0.43 5.47 0.32 1.02e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4722166 0.532 rs4719713 chr7:22758811 G/A cg05472934 chr7:22766657 IL6 0.5 6.52 0.37 3.59e-10 Lung cancer; CESC cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.42 6.16 0.35 2.75e-9 Eosinophil percentage of white cells; CESC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg02725872 chr8:58115012 NA -0.34 -5.2 -0.3 3.99e-7 Developmental language disorder (linguistic errors); CESC cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.18 0.3 4.34e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg04944784 chr2:26401820 FAM59B 0.96 10.5 0.54 8.76e-22 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs2064088 chr22:39053382 A/G cg06022373 chr22:39101656 GTPBP1 0.88 13.91 0.65 2.06e-33 Menopause (age at onset); CESC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg16606324 chr3:10149918 C3orf24 0.41 5.09 0.3 6.8e-7 Alzheimer's disease; CESC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg07507251 chr3:52567010 NT5DC2 0.36 6.46 0.37 5.02e-10 Bipolar disorder; CESC cis rs9831754 0.756 rs2872626 chr3:78435049 A/T cg06138941 chr3:78371609 NA -0.48 -6.0 -0.35 6.33e-9 Calcium levels; CESC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.49 -6.06 -0.35 4.66e-9 Tonsillectomy; CESC cis rs863345 0.604 rs12041350 chr1:158482048 A/G cg12129480 chr1:158549410 OR10X1 -0.34 -6.74 -0.38 9.86e-11 Pneumococcal bacteremia; CESC cis rs5769765 0.955 rs2295406 chr22:50260169 G/A cg02269571 chr22:50332266 NA 0.47 6.29 0.36 1.3e-9 Schizophrenia; CESC cis rs72949976 0.898 rs6732233 chr2:214022834 C/T cg08319019 chr2:214017104 IKZF2 -0.42 -5.07 -0.3 7.37e-7 Lung cancer;Squamous cell lung carcinoma; CESC cis rs1023500 0.505 rs2143139 chr22:42614401 G/C cg15557168 chr22:42548783 NA -0.41 -6.02 -0.35 5.69e-9 Schizophrenia; CESC cis rs4253772 0.591 rs6008361 chr22:46652372 A/G cg09491104 chr22:46646882 C22orf40 0.64 10.02 0.52 3.12e-20 LDL cholesterol;Cholesterol, total; CESC cis rs4835473 0.897 rs6846984 chr4:144904251 G/C cg25736465 chr4:144833511 NA 0.41 6.16 0.35 2.72e-9 Immature fraction of reticulocytes; CESC cis rs68092024 0.704 rs704576 chr3:99487154 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.43 -6.77 -0.38 8.4e-11 Cleft lip with or without cleft palate; CESC cis rs2635047 0.967 rs2247784 chr18:44746997 G/A cg19077165 chr18:44547161 KATNAL2 -0.45 -6.0 -0.35 6.38e-9 Educational attainment; CESC cis rs10883723 0.810 rs17782574 chr10:104279394 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.42 0.41 1.57e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs1707322 0.682 rs28490344 chr1:46197948 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs763121 0.853 rs9622833 chr22:39000397 G/A cg06022373 chr22:39101656 GTPBP1 0.84 12.31 0.6 7.77e-28 Menopause (age at onset); CESC cis rs713587 0.624 rs1550110 chr2:25124563 T/C cg01884057 chr2:25150051 NA 0.36 6.98 0.39 2.32e-11 Body mass index in non-asthmatics; CESC cis rs4268898 0.717 rs2543662 chr2:24443271 G/T cg20701182 chr2:24300061 SF3B14 -0.49 -5.72 -0.33 2.94e-8 Asthma; CESC cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.55 6.72 0.38 1.1e-10 Axial length; CESC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg08859206 chr1:53392774 SCP2 0.53 7.09 0.4 1.19e-11 Monocyte count; CESC cis rs6740322 0.901 rs2163228 chr2:43549246 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.6 -5.89 -0.34 1.19e-8 Coronary artery disease; CESC cis rs2243480 1.000 rs1964692 chr7:65454183 G/A cg25894440 chr7:65020034 NA -0.65 -5.63 -0.33 4.5e-8 Diabetic kidney disease; CESC cis rs7264396 0.790 rs2295355 chr20:34252654 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.66 7.92 0.44 6.7e-14 Total cholesterol levels; CESC cis rs11122272 0.735 rs2486728 chr1:231535883 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.73 -0.43 2.29e-13 Hemoglobin concentration; CESC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg04756594 chr16:24857601 SLC5A11 0.45 5.53 0.32 7.79e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs9833726 0.727 rs71318644 chr3:86129349 A/G cg10416071 chr15:75628863 COMMD4 0.59 6.12 0.35 3.37e-9 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23967809 chr8:141647658 NA -0.41 -6.14 -0.35 3.06e-9 Gambling; CESC cis rs8060686 0.565 rs75735284 chr16:68126635 C/A cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 4.92e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs2637266 1.000 rs3923670 chr10:78375001 C/G cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC cis rs10927875 1.000 rs3979179 chr1:16306846 A/G cg21385522 chr1:16154831 NA 0.82 10.47 0.54 1.09e-21 Dilated cardiomyopathy; CESC cis rs1904096 0.513 rs2632405 chr4:95152215 T/G cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Type 2 diabetes; CESC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg25124228 chr12:125621409 AACS -0.54 -7.2 -0.4 6.37e-12 Post bronchodilator FEV1/FVC ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01305483 chr7:935436 C7orf20 -0.55 -6.15 -0.35 2.85e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15739904 chr8:125313885 NA 0.51 7.06 0.4 1.46e-11 Fibrinogen levels; CESC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg12963246 chr6:28129442 ZNF389 0.5 6.76 0.38 8.57e-11 Depression; CESC cis rs17253792 0.822 rs10151664 chr14:56029533 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.73 5.52 0.32 8.19e-8 Putamen volume; CESC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg03709012 chr19:19516395 GATAD2A 1.01 14.94 0.68 5.1e-37 Tonsillectomy; CESC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg09177884 chr7:1199841 ZFAND2A -0.45 -5.61 -0.33 5.1e-8 Longevity;Endometriosis; CESC cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg03060546 chr3:49711283 APEH 0.44 5.48 0.32 9.71e-8 Parkinson's disease; CESC cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg13877915 chr19:58951672 ZNF132 0.39 5.8 0.34 1.93e-8 Uric acid clearance; CESC cis rs28374715 0.681 rs7162231 chr15:41591859 G/A cg18705301 chr15:41695430 NDUFAF1 -1.0 -14.55 -0.67 1.24e-35 Ulcerative colitis; CESC trans rs35110281 0.776 rs9983763 chr21:44990578 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.56 -7.23 -0.41 5.32e-12 Mean corpuscular volume; CESC cis rs909674 0.662 rs2899318 chr22:39837625 A/G cg02038168 chr22:39784481 NA -0.69 -8.61 -0.47 6.42e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7772486 0.651 rs1292338 chr6:145967471 A/C cg05347473 chr6:146136440 FBXO30 -0.52 -6.83 -0.39 5.76e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7927771 0.524 rs2290851 chr11:47753370 C/T cg18512352 chr11:47633146 NA -0.36 -5.64 -0.33 4.36e-8 Subjective well-being; CESC cis rs6582630 0.638 rs7963994 chr12:38555535 G/A cg26384229 chr12:38710491 ALG10B -0.39 -5.19 -0.3 4.24e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs36051895 0.632 rs7040806 chr9:5174782 C/T cg02405213 chr9:5042618 JAK2 -0.52 -6.65 -0.38 1.72e-10 Pediatric autoimmune diseases; CESC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg12463550 chr7:65579703 CRCP -0.51 -6.51 -0.37 3.74e-10 Aortic root size; CESC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs2637266 0.739 rs2395404 chr10:78380513 G/T cg18941641 chr10:78392320 NA 0.43 8.11 0.45 1.88e-14 Pulmonary function; CESC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.93 -0.34 9.59e-9 Menopause (age at onset); CESC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg08822215 chr16:89438651 ANKRD11 -0.36 -5.52 -0.32 8.06e-8 Multiple myeloma (IgH translocation); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg27429832 chr16:1398627 BAIAP3 0.43 6.83 0.39 5.78e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg10295955 chr4:187884368 NA -1.08 -23.15 -0.82 1.38e-65 Lobe attachment (rater-scored or self-reported); CESC cis rs3931020 0.508 rs28568334 chr1:75199299 C/G cg10128416 chr1:75198403 TYW3;CRYZ 0.46 5.53 0.32 7.52e-8 Resistin levels; CESC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg18904891 chr8:8559673 CLDN23 0.68 8.07 0.44 2.45e-14 Obesity-related traits; CESC cis rs4141404 0.604 rs5753625 chr22:31854846 C/T cg00478049 chr22:31556069 RNF185 0.4 5.03 0.3 9.08e-7 Paclitaxel-induced neuropathy; CESC cis rs2243480 1.000 rs1723267 chr7:65473314 G/A cg13147721 chr7:65941812 NA -0.89 -8.55 -0.47 9.65e-16 Diabetic kidney disease; CESC cis rs1059312 0.932 rs4760592 chr12:129287149 G/C cg09035930 chr12:129282057 SLC15A4 0.78 10.94 0.56 3.13e-23 Systemic lupus erythematosus; CESC cis rs2282802 0.651 rs10060071 chr5:139599097 T/C cg26211634 chr5:139558579 C5orf32 0.5 7.38 0.41 2.03e-12 Intelligence (multi-trait analysis); CESC cis rs17376456 0.877 rs12716460 chr5:93416733 A/G cg25358565 chr5:93447407 FAM172A 1.14 11.27 0.57 2.51e-24 Diabetic retinopathy; CESC cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.45 7.61 0.42 4.9e-13 Hemoglobin concentration; CESC cis rs1348850 0.831 rs7606235 chr2:178401288 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.83 11.32 0.57 1.71e-24 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs13427251 0.903 rs6746402 chr2:100150443 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.54 -7.12 -0.4 9.92e-12 Chronic sinus infection; CESC cis rs4595586 0.545 rs12828790 chr12:39401043 G/A cg13010199 chr12:38710504 ALG10B 0.44 5.6 0.33 5.42e-8 Morning vs. evening chronotype; CESC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg21017887 chr14:105400489 NA 0.41 6.68 0.38 1.42e-10 Rheumatoid arthritis; CESC cis rs10504229 1.000 rs59275611 chr8:58195191 G/A cg14926445 chr8:58193284 C8orf71 -0.56 -5.86 -0.34 1.38e-8 Developmental language disorder (linguistic errors); CESC trans rs79976124 1.000 rs79976124 chr6:66618657 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.75 8.32 0.46 4.83e-15 Type 2 diabetes; CESC cis rs722599 1.000 rs722599 chr14:75327443 T/C cg11812906 chr14:75593930 NEK9 -0.4 -5.08 -0.3 7.29e-7 IgG glycosylation; CESC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg22920501 chr2:26401640 FAM59B -0.78 -9.1 -0.49 2.17e-17 Gut microbiome composition (summer); CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg15112475 chr7:1198522 ZFAND2A -0.44 -6.99 -0.39 2.18e-11 Longevity;Endometriosis; CESC cis rs2463822 0.748 rs2513038 chr11:62081329 A/C cg06239285 chr11:62104954 ASRGL1 0.94 8.8 0.48 1.75e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg16325326 chr1:53192061 ZYG11B -0.69 -10.87 -0.56 5.49e-23 Monocyte count; CESC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg23985595 chr17:80112537 CCDC57 0.41 6.34 0.36 9.63e-10 Life satisfaction; CESC cis rs7267979 0.789 rs62213729 chr20:25363426 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -11.87 -0.59 2.34e-26 Liver enzyme levels (alkaline phosphatase); CESC cis rs193541 0.632 rs154504 chr5:122204086 A/T cg19412675 chr5:122181750 SNX24 0.48 5.65 0.33 4.11e-8 Glucose homeostasis traits; CESC cis rs10751667 0.666 rs4072741 chr11:976565 T/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.33 -0.31 2.08e-7 Alzheimer's disease (late onset); CESC cis rs6446731 0.517 rs2798221 chr4:3270488 T/C cg08886695 chr4:3369023 RGS12 0.39 5.77 0.33 2.21e-8 Mean platelet volume; CESC cis rs6499255 0.904 rs2161631 chr16:69556948 C/A cg15192750 chr16:69999425 NA 0.51 5.85 0.34 1.47e-8 IgE levels; CESC cis rs2657888 0.593 rs2638319 chr12:56857057 A/G cg23002907 chr12:56915593 RBMS2 -0.38 -5.09 -0.3 6.66e-7 Adiponectin levels; CESC cis rs73206853 0.640 rs3825390 chr12:110976409 A/C cg12870014 chr12:110450643 ANKRD13A 0.77 7.25 0.41 4.5e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg20887711 chr4:1340912 KIAA1530 0.92 12.09 0.6 4.36e-27 Longevity; CESC cis rs4654899 1.000 rs885363 chr1:21325360 C/A cg05370193 chr1:21551575 ECE1 0.41 6.3 0.36 1.21e-9 Superior frontal gyrus grey matter volume; CESC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg27478167 chr7:817139 HEATR2 -0.54 -5.74 -0.33 2.58e-8 Cerebrospinal P-tau181p levels; CESC cis rs4481887 1.000 rs6671789 chr1:248482931 G/A cg00666640 chr1:248458726 OR2T12 0.41 6.64 0.38 1.75e-10 Common traits (Other); CESC cis rs287982 0.935 rs1119632 chr2:9967664 C/A cg10881225 chr2:9984929 TAF1B 0.42 5.31 0.31 2.27e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg17644776 chr2:200775616 C2orf69 0.55 6.72 0.38 1.13e-10 Osteoporosis; CESC cis rs9911578 1.000 rs11869828 chr17:56609525 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC cis rs9467773 0.620 rs2504567 chr6:26662920 C/G cg11502198 chr6:26597334 ABT1 0.53 7.62 0.42 4.39e-13 Intelligence (multi-trait analysis); CESC cis rs72627509 0.904 rs7687767 chr4:57824932 C/T cg26694713 chr4:57773883 REST -0.54 -5.34 -0.31 1.99e-7 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg04414720 chr1:150670196 GOLPH3L -0.37 -5.14 -0.3 5.41e-7 Tonsillectomy; CESC cis rs2882667 0.858 rs2043271 chr5:138459108 A/G cg04439458 chr5:138467593 SIL1 -0.34 -5.29 -0.31 2.52e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs10779751 0.734 rs910660 chr1:11130643 C/T cg08854313 chr1:11322531 MTOR -0.76 -10.12 -0.53 1.49e-20 Body mass index; CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg09177884 chr7:1199841 ZFAND2A -0.58 -7.99 -0.44 4.11e-14 Longevity;Endometriosis; CESC cis rs2635047 0.507 rs2668767 chr18:44785302 T/C cg24371990 chr18:44770781 NA 0.36 5.73 0.33 2.73e-8 Educational attainment; CESC cis rs27434 0.583 rs34761 chr5:96153624 C/T cg16492584 chr5:96139282 ERAP1 -0.4 -5.66 -0.33 3.92e-8 Ankylosing spondylitis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24001719 chr20:25388278 GINS1 -0.49 -6.39 -0.37 7.22e-10 Asthma; CESC cis rs17826219 0.636 rs79565452 chr17:29142841 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.55 0.37 2.94e-10 Body mass index; CESC cis rs372883 0.600 rs2832298 chr21:30743863 C/G cg08807101 chr21:30365312 RNF160 0.44 5.16 0.3 4.78e-7 Pancreatic cancer; CESC cis rs1953600 0.668 rs11201879 chr10:81908573 A/C cg04850286 chr10:81895943 PLAC9 0.31 5.28 0.31 2.74e-7 Sarcoidosis; CESC cis rs1882538 0.564 rs10488164 chr7:133106199 A/G cg10665199 chr7:133106180 EXOC4 0.61 8.34 0.46 4.02e-15 Intelligence (multi-trait analysis); CESC trans rs629535 0.773 rs72654090 chr8:70118666 G/A cg21567404 chr3:27674614 NA -0.87 -10.2 -0.53 8.16e-21 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04203450 chr20:36028737 SRC -0.52 -6.06 -0.35 4.59e-9 Gut microbiome composition (summer); CESC cis rs763121 1.000 rs763121 chr22:38879940 C/T cg06544989 chr22:39130855 UNC84B -0.38 -6.47 -0.37 4.65e-10 Menopause (age at onset); CESC cis rs17384381 1.000 rs36110608 chr1:85852936 A/C cg16011679 chr1:85725395 C1orf52 0.79 8.08 0.44 2.34e-14 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23598054 chr2:201754268 NIF3L1;PPIL3 -0.44 -6.72 -0.38 1.14e-10 Gambling; CESC cis rs1670533 1.000 rs688785 chr4:1082707 G/C cg04106633 chr4:1044584 NA 0.4 5.1 0.3 6.33e-7 Recombination rate (females); CESC cis rs6063312 0.935 rs6095256 chr20:47340806 C/T cg18078177 chr20:47281410 PREX1 0.57 5.69 0.33 3.28e-8 Tonometry; CESC cis rs7098414 0.511 rs7898787 chr10:82156042 G/A cg00277334 chr10:82204260 NA -0.5 -7.47 -0.42 1.17e-12 Post bronchodilator FEV1; CESC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg22903471 chr2:27725779 GCKR -0.56 -7.84 -0.43 1.09e-13 Total body bone mineral density; CESC cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg12826209 chr6:26865740 GUSBL1 0.73 8.53 0.46 1.14e-15 Intelligence (multi-trait analysis); CESC cis rs1538970 0.924 rs4660851 chr1:45843810 A/T cg05343316 chr1:45956843 TESK2 0.81 11.55 0.58 2.79e-25 Platelet count; CESC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg18876405 chr7:65276391 NA -0.53 -7.3 -0.41 3.31e-12 Aortic root size; CESC cis rs1707322 1.000 rs7526369 chr1:46390560 G/C cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg10792982 chr14:105748885 BRF1 0.42 5.37 0.31 1.75e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7828089 0.875 rs6998575 chr8:22254499 C/T cg12081754 chr8:22256438 SLC39A14 0.51 7.39 0.41 1.9e-12 Verbal declarative memory; CESC cis rs7772486 0.754 rs4566902 chr6:146244128 A/G cg23711669 chr6:146136114 FBXO30 -0.92 -13.36 -0.63 1.78e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs2439831 0.867 rs933941 chr15:43632226 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.86 12.53 0.61 1.34e-28 Lung cancer in ever smokers; CESC cis rs2742417 1.000 rs2673056 chr3:45737802 C/T cg10512202 chr3:45649293 LIMD1 0.36 5.16 0.3 4.9e-7 Response to anti-depressant treatment in major depressive disorder; CESC cis rs752010 0.902 rs60743712 chr1:42076629 G/A cg06885757 chr1:42089581 HIVEP3 0.52 8.42 0.46 2.44e-15 Lupus nephritis in systemic lupus erythematosus; CESC trans rs4332037 0.539 rs11762545 chr7:2060775 C/T cg11693508 chr17:37793320 STARD3 0.66 6.63 0.38 1.84e-10 Bipolar disorder; CESC cis rs7851660 0.844 rs10759975 chr9:100625193 C/T cg13688889 chr9:100608707 NA 0.63 8.84 0.48 1.41e-16 Strep throat; CESC cis rs11122272 0.735 rs2739507 chr1:231527329 T/C cg06096015 chr1:231504339 EGLN1 0.4 5.77 0.33 2.23e-8 Hemoglobin concentration; CESC trans rs1814175 0.645 rs10444311 chr11:49986906 A/G cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs9549367 0.662 rs3818334 chr13:113825174 C/G cg00898013 chr13:113819073 PROZ -0.54 -7.27 -0.41 4.12e-12 Platelet distribution width; CESC cis rs894734 0.535 rs2366144 chr12:54324069 G/T cg17410650 chr12:54324560 NA -0.47 -8.91 -0.48 8.57e-17 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CESC cis rs1538970 0.962 rs2298018 chr1:45813441 T/C cg05343316 chr1:45956843 TESK2 0.77 10.75 0.55 1.34e-22 Platelet count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13680954 chr1:1850738 TMEM52 0.39 6.08 0.35 4.25e-9 Gambling; CESC cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.16e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 1.000 rs2159583 chr4:17658838 T/C cg02297831 chr4:17616191 MED28 0.54 6.87 0.39 4.6e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs892961 1.000 rs1110638 chr17:75400690 T/C cg05865280 chr17:75406074 SEPT9 0.63 12.07 0.6 5.13e-27 Airflow obstruction; CESC cis rs1545257 0.505 rs7595372 chr2:24632122 A/C cg06627628 chr2:24431161 ITSN2 -0.48 -5.85 -0.34 1.41e-8 Sjögren's syndrome; CESC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg00310523 chr12:86230176 RASSF9 0.41 6.23 0.36 1.85e-9 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04547554 chr19:41860013 TGFB1 0.53 6.15 0.35 2.82e-9 Gut microbiome composition (summer); CESC cis rs11608355 0.521 rs11066503 chr12:109842434 A/G cg19025524 chr12:109796872 NA -0.53 -7.28 -0.41 3.84e-12 Neuroticism; CESC cis rs9487051 0.714 rs6903695 chr6:109631422 C/G cg12927641 chr6:109611667 NA 0.35 5.22 0.31 3.66e-7 Reticulocyte fraction of red cells; CESC trans rs11098499 0.863 rs3736115 chr4:120488703 A/G cg25214090 chr10:38739885 LOC399744 -0.65 -8.43 -0.46 2.28e-15 Corneal astigmatism; CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg15147215 chr3:52552868 STAB1 -0.33 -5.96 -0.34 7.82e-9 Bipolar disorder; CESC cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg23583168 chr7:148888333 NA -0.73 -10.45 -0.54 1.28e-21 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3617 0.539 rs4687689 chr3:52948674 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.32 -5.27 -0.31 2.8e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg05313129 chr8:58192883 C8orf71 -0.54 -6.13 -0.35 3.13e-9 Developmental language disorder (linguistic errors); CESC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg17376030 chr22:41985996 PMM1 0.67 7.19 0.4 6.44e-12 Vitiligo; CESC cis rs11997175 0.646 rs4463379 chr8:33692719 G/A ch.8.33884649F chr8:33765107 NA 0.57 7.42 0.41 1.61e-12 Body mass index; CESC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg18876405 chr7:65276391 NA -0.53 -6.94 -0.39 2.96e-11 Aortic root size; CESC cis rs6582630 0.638 rs12425379 chr12:38523705 G/A cg26384229 chr12:38710491 ALG10B -0.45 -6.06 -0.35 4.57e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7659604 0.605 rs1396080 chr4:122740454 T/G cg19748678 chr4:122722346 EXOSC9 0.72 9.27 0.49 6.93e-18 Type 2 diabetes; CESC trans rs7246657 0.941 rs12982333 chr19:37794724 A/G cg01833234 chr11:6592585 DNHD1 0.54 6.13 0.35 3.19e-9 Coronary artery calcification; CESC cis rs225245 0.755 rs226432 chr17:34043825 G/A cg05299278 chr17:33885742 SLFN14 -0.38 -5.36 -0.31 1.82e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs8177253 0.514 rs6790668 chr3:133442481 T/A cg18769074 chr3:133464867 TF 0.27 5.23 0.31 3.37e-7 Iron status biomarkers; CESC cis rs10089 1.000 rs73337363 chr5:127483597 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.51 0.54 8.08e-22 Ileal carcinoids; CESC cis rs1005224 0.963 rs12887886 chr14:76167846 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.41 -5.76 -0.33 2.39e-8 Large artery stroke; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14178837 chr14:39639234 TRAPPC6B -0.56 -6.15 -0.35 2.84e-9 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg11663144 chr21:46675770 NA -0.64 -10.07 -0.53 2.16e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10225163 1.000 rs10225163 chr7:27925645 C/G cg05786569 chr7:27702416 HIBADH -0.4 -5.23 -0.31 3.48e-7 Gout; CESC cis rs7914558 1.000 rs943038 chr10:104826261 T/C cg04362960 chr10:104952993 NT5C2 0.47 6.32 0.36 1.11e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7659604 1.000 rs6814995 chr4:122664963 A/T cg19671926 chr4:122722719 EXOSC9 0.45 5.3 0.31 2.43e-7 Type 2 diabetes; CESC cis rs7481584 1.000 rs12786344 chr11:3021392 G/A cg25174290 chr11:3078921 CARS -0.43 -5.36 -0.31 1.78e-7 Calcium levels; CESC cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs1580019 0.885 rs3801331 chr7:32497039 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.88 -12.35 -0.6 5.45e-28 Cognitive ability; CESC cis rs1729951 0.575 rs361241 chr3:136699561 C/A cg04103450 chr3:136751342 NA 0.38 5.07 0.3 7.54e-7 Neuroticism; CESC cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg18904891 chr8:8559673 CLDN23 0.69 8.59 0.47 7.39e-16 Obesity-related traits; CESC cis rs3026101 0.599 rs1058381 chr17:5288018 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.89 0.34 1.19e-8 Body mass index; CESC cis rs9649465 0.561 rs688242 chr7:123420442 C/A cg03229431 chr7:123269106 ASB15 0.42 5.65 0.33 4.24e-8 Migraine; CESC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg11366901 chr6:160182831 ACAT2 0.65 8.27 0.45 6.51e-15 Age-related macular degeneration (geographic atrophy); CESC cis rs1801251 0.928 rs737028 chr2:233640750 T/C cg08000102 chr2:233561755 GIGYF2 0.66 9.35 0.5 3.83e-18 Coronary artery disease; CESC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg04369109 chr6:150039330 LATS1 -0.42 -5.69 -0.33 3.41e-8 Lung cancer; CESC cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg22508957 chr16:3507546 NAT15 0.4 5.42 0.32 1.33e-7 Body mass index (adult); CESC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg22433210 chr17:43662623 NA 0.99 11.09 0.56 9.69e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.94 0.65 1.73e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8062405 0.756 rs151301 chr16:28497059 T/A cg05966235 chr16:28915196 ATP2A1 0.37 5.17 0.3 4.62e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs11098499 0.863 rs34308924 chr4:120481431 T/C cg09307838 chr4:120376055 NA 0.9 12.45 0.61 2.6e-28 Corneal astigmatism; CESC trans rs11039798 1.000 rs12225599 chr11:48755868 T/C cg15704280 chr7:45808275 SEPT13 0.69 6.29 0.36 1.33e-9 Axial length; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03610000 chr11:128392383 ETS1 -0.43 -6.01 -0.35 5.99e-9 Fibrinogen levels; CESC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg07747251 chr5:1868357 NA 0.34 5.7 0.33 3.17e-8 Cardiovascular disease risk factors; CESC cis rs7795096 0.806 rs1109277 chr7:151540959 C/G cg17008978 chr7:151542804 PRKAG2 -0.4 -7.54 -0.42 7.6e-13 Bipolar disorder (age of onset and psychotic symptoms); CESC cis rs863345 0.967 rs12133354 chr1:158526537 T/C cg12129480 chr1:158549410 OR10X1 -0.32 -6.54 -0.37 3.13e-10 Pneumococcal bacteremia; CESC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.17 0.49 1.32e-17 Menopause (age at onset); CESC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg13114125 chr14:105738426 BRF1 -0.85 -10.46 -0.54 1.18e-21 Mean platelet volume;Platelet distribution width; CESC cis rs7520050 0.966 rs6700597 chr1:46284246 G/A cg03146154 chr1:46216737 IPP -0.47 -6.19 -0.36 2.34e-9 Red blood cell count;Reticulocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19840540 chr4:159593380 ETFDH;C4orf46 -0.47 -6.93 -0.39 3.1e-11 Gambling; CESC cis rs2742234 0.590 rs2435337 chr10:43661836 G/C cg15436174 chr10:43711423 RASGEF1A -0.51 -5.84 -0.34 1.54e-8 Hirschsprung disease; CESC cis rs2952156 0.920 rs2934951 chr17:37833328 A/G cg20243544 chr17:37824526 PNMT 0.63 7.97 0.44 4.89e-14 Asthma; CESC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.09 0.6 4.15e-27 Alzheimer's disease; CESC cis rs965469 1.000 rs6139064 chr20:3277050 G/T cg25506879 chr20:3388711 C20orf194 -0.54 -5.88 -0.34 1.24e-8 IFN-related cytopenia; CESC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg09323728 chr8:95962352 TP53INP1 -0.41 -9.06 -0.49 2.87e-17 Type 2 diabetes; CESC cis rs2996428 0.561 rs72640913 chr1:3747023 C/G cg10555106 chr1:3691387 LOC388588 0.37 5.4 0.31 1.48e-7 Red cell distribution width; CESC cis rs6061231 0.761 rs2427312 chr20:60970591 C/T cg24112000 chr20:60950667 NA -0.69 -6.84 -0.39 5.46e-11 Colorectal cancer; CESC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg16545954 chr1:2118288 C1orf86 -0.31 -5.64 -0.33 4.43e-8 Height; CESC cis rs12142240 0.698 rs10158130 chr1:46822600 T/C cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs11785400 0.963 rs9771845 chr8:143726577 C/G cg10596483 chr8:143751796 JRK 0.42 5.47 0.32 1.05e-7 Schizophrenia; CESC cis rs4253772 0.638 rs6007845 chr22:46718417 A/T cg24881330 chr22:46731750 TRMU -0.88 -10.27 -0.53 4.84e-21 LDL cholesterol;Cholesterol, total; CESC cis rs853679 0.882 rs9468287 chr6:28079741 G/T cg18032046 chr6:28092343 ZSCAN16 -0.71 -6.29 -0.36 1.27e-9 Depression; CESC cis rs12477438 0.834 rs1563106 chr2:99701381 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.07 -0.53 2.12e-20 Chronic sinus infection; CESC cis rs6582630 0.502 rs11181214 chr12:38298313 C/A cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.23e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs858239 0.600 rs6960001 chr7:23130876 T/C cg23682824 chr7:23144976 KLHL7 0.55 7.67 0.43 3.39e-13 Cerebrospinal fluid biomarker levels; CESC cis rs611744 0.647 rs2859813 chr8:109263497 G/A cg21045802 chr8:109455806 TTC35 0.46 5.69 0.33 3.37e-8 Dupuytren's disease; CESC cis rs863345 0.565 rs12403685 chr1:158452399 C/T cg12129480 chr1:158549410 OR10X1 0.3 6.18 0.35 2.41e-9 Pneumococcal bacteremia; CESC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs3026101 0.723 rs1806247 chr17:5310409 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs9399401 0.601 rs171891 chr6:142850612 G/A cg03128060 chr6:142623767 GPR126 0.41 6.68 0.38 1.42e-10 Chronic obstructive pulmonary disease; CESC cis rs9814567 0.964 rs9833753 chr3:134213665 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.99 -0.35 6.9e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs637571 0.544 rs56239996 chr11:65730003 A/T cg17712092 chr4:129076599 LARP1B 0.75 10.36 0.54 2.43e-21 Eosinophil percentage of white cells; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05695311 chr8:37887949 EIF4EBP1 -0.5 -6.27 -0.36 1.48e-9 Ulcerative colitis; CESC cis rs17401966 0.965 rs12751375 chr1:10291874 C/G cg15208524 chr1:10270712 KIF1B 0.5 6.55 0.37 2.97e-10 Hepatocellular carcinoma; CESC cis rs561341 0.800 rs7209766 chr17:30234848 T/A cg13647721 chr17:30228624 UTP6 0.79 9.4 0.5 2.71e-18 Hip circumference adjusted for BMI; CESC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg08888203 chr3:10149979 C3orf24 0.52 6.09 0.35 3.95e-9 Alzheimer's disease; CESC cis rs80130819 0.515 rs1635536 chr12:48385945 A/G cg05342945 chr12:48394962 COL2A1 -0.54 -6.43 -0.37 5.94e-10 Prostate cancer; CESC cis rs6582630 0.519 rs10880629 chr12:38533611 T/G cg26384229 chr12:38710491 ALG10B 0.71 10.89 0.56 4.51e-23 Drug-induced liver injury (flucloxacillin); CESC trans rs9929218 0.954 rs7186333 chr16:68815838 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -8.88 -0.48 1.05e-16 Colorectal cancer; CESC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg03452623 chr4:187889614 NA -0.88 -16.46 -0.71 2.04e-42 Lobe attachment (rater-scored or self-reported); CESC cis rs9400467 0.506 rs12203093 chr6:111585382 T/C cg15721981 chr6:111408429 SLC16A10 0.52 5.03 0.3 8.93e-7 Blood metabolite levels;Amino acid levels; CESC cis rs7520050 0.807 rs28647556 chr1:46206399 G/A cg03146154 chr1:46216737 IPP 0.5 6.71 0.38 1.16e-10 Red blood cell count;Reticulocyte count; CESC cis rs8114671 0.562 rs6088622 chr20:33419977 C/A cg07148914 chr20:33460835 GGT7 0.41 5.28 0.31 2.71e-7 Height; CESC cis rs2034088 0.965 rs11651340 chr17:425099 A/C cg06217071 chr17:408420 NA -0.42 -7.19 -0.4 6.62e-12 Hip circumference adjusted for BMI; CESC cis rs2933343 0.700 rs789240 chr3:128630635 T/C cg25356066 chr3:128598488 ACAD9 0.58 7.92 0.44 6.51e-14 IgG glycosylation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05207834 chr17:49199381 SPAG9 -0.41 -6.06 -0.35 4.6e-9 Gambling; CESC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.86 0.34 1.4e-8 Bipolar disorder; CESC cis rs12477438 0.798 rs2045057 chr2:99684929 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg00945666 chr1:160990265 F11R -0.34 -5.45 -0.32 1.16e-7 Granulocyte percentage of myeloid white cells; CESC cis rs17401966 1.000 rs12755094 chr1:10305711 T/C cg15208524 chr1:10270712 KIF1B 0.43 5.77 0.33 2.16e-8 Hepatocellular carcinoma; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16739247 chr1:76252438 SNORD45C;SNORD45A;RABGGTB 0.54 7.29 0.41 3.66e-12 Systemic lupus erythematosus; CESC cis rs2243480 0.908 rs313822 chr7:65573939 G/A cg18252515 chr7:66147081 NA -1.38 -13.61 -0.64 2.47e-32 Diabetic kidney disease; CESC cis rs7223966 0.960 rs2854222 chr17:61939015 C/T cg11494091 chr17:61959527 GH2 0.39 5.53 0.32 7.54e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.21 0.36 2e-9 Menopause (age at onset); CESC cis rs2842992 0.750 rs2758354 chr6:160125854 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.11 0.49 2.04e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs1879734 0.636 rs17109178 chr1:54173551 C/G cg23596471 chr1:54105337 GLIS1 0.31 5.03 0.3 8.88e-7 Mitral valve prolapse; CESC cis rs7666738 0.830 rs7680909 chr4:98934604 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg11890956 chr21:40555474 PSMG1 1.16 21.78 0.8 5.46e-61 Cognitive function; CESC cis rs1707322 1.000 rs4660331 chr1:46458783 A/C cg06784218 chr1:46089804 CCDC17 0.33 5.74 0.33 2.64e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13588715 chr4:164415922 C4orf43 -0.55 -6.37 -0.36 8.47e-10 Gut microbiome composition (summer); CESC cis rs7580658 0.963 rs12622436 chr2:128081682 C/A cg10021288 chr2:128175891 PROC -0.41 -6.49 -0.37 4.24e-10 Protein C levels; CESC cis rs2243480 1.000 rs34702770 chr7:65344823 T/C cg25894440 chr7:65020034 NA -0.6 -5.32 -0.31 2.19e-7 Diabetic kidney disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05520288 chr5:34929958 DNAJC21 -0.48 -6.1 -0.35 3.69e-9 Asthma; CESC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg06028808 chr11:68637592 NA 0.48 5.68 0.33 3.55e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7949030 0.626 rs61296092 chr11:62320838 T/C cg22862634 chr11:62369728 EML3;MTA2 0.61 8.53 0.46 1.11e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.37 0.36 8.35e-10 Bipolar disorder; CESC cis rs9640161 0.711 rs3800781 chr7:150027324 T/A cg10018233 chr7:150070692 REPIN1 0.47 6.94 0.39 3.01e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg04414720 chr1:150670196 GOLPH3L -0.37 -5.26 -0.31 3.03e-7 Tonsillectomy; CESC cis rs2073300 1.000 rs6048803 chr20:23438889 A/G cg12062639 chr20:23401060 NAPB 0.67 5.15 0.3 5.15e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7894051 1.000 rs7074435 chr10:135190570 G/T cg24905316 chr10:135186343 ECHS1 0.69 5.87 0.34 1.31e-8 Lifespan; CESC cis rs1707322 0.890 rs2297883 chr1:46511487 G/C cg03146154 chr1:46216737 IPP -0.72 -9.73 -0.51 2.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6674176 0.660 rs11210936 chr1:44391438 A/T cg12908607 chr1:44402522 ARTN -0.51 -7.54 -0.42 7.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03909097 chr20:30555528 XKR7 -0.64 -7.56 -0.42 6.69e-13 Gut microbiome composition (summer); CESC cis rs1577917 1.000 rs12203493 chr6:86758642 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.01 -0.35 5.96e-9 Response to antipsychotic treatment; CESC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg03647317 chr4:187891568 NA 0.45 7.07 0.4 1.34e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1986734 0.597 rs4859684 chr4:77419107 C/T cg20311846 chr4:77356250 SHROOM3 -0.27 -5.39 -0.31 1.53e-7 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC cis rs854765 0.724 rs2955371 chr17:17967397 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.46 -5.96 -0.34 8.06e-9 Total body bone mineral density; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24748448 chr17:3493352 TRPV1 -0.43 -6.01 -0.35 6.15e-9 Asthma; CESC cis rs9584850 0.834 rs12869627 chr13:99120452 G/A cg20750642 chr13:99100586 FARP1 -0.37 -5.56 -0.32 6.44e-8 Neuroticism; CESC cis rs6594713 0.717 rs13174075 chr5:112795352 A/T cg12552261 chr5:112820674 MCC 0.53 5.13 0.3 5.64e-7 Brain cytoarchitecture; CESC cis rs1124376 1.000 rs9857135 chr3:20147790 G/A cg05072819 chr3:20081367 KAT2B 0.47 5.14 0.3 5.39e-7 Bipolar disorder and schizophrenia; CESC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 5.97 0.34 7.42e-9 Bipolar disorder; CESC cis rs72901758 0.768 rs72901766 chr17:76245203 G/C cg26068271 chr17:76253126 NA 0.51 7.68 0.43 3.15e-13 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs2408955 0.522 rs4760679 chr12:48461635 G/T cg04545296 chr12:48745243 ZNF641 -0.36 -6.23 -0.36 1.86e-9 Glycated hemoglobin levels; CESC cis rs9457247 0.508 rs6918286 chr6:167505829 C/T cg07741184 chr6:167504864 NA 0.33 5.73 0.33 2.76e-8 Crohn's disease; CESC cis rs8067545 0.611 rs2703776 chr17:20137709 C/A cg13482628 chr17:19912719 NA -0.42 -5.63 -0.33 4.63e-8 Schizophrenia; CESC cis rs28374715 0.528 rs7181982 chr15:41623020 C/G cg02330683 chr15:41787940 ITPKA 0.49 5.81 0.34 1.77e-8 Ulcerative colitis; CESC cis rs4629180 1.000 rs6744495 chr2:102099956 T/C cg01388757 chr2:102091195 RFX8 -0.44 -6.78 -0.38 7.91e-11 Chronic rhinosinusitis with nasal polyps; CESC cis rs1801251 0.778 rs778340 chr2:233734083 C/T cg25237894 chr2:233734115 C2orf82 -0.52 -9.37 -0.5 3.4e-18 Coronary artery disease; CESC cis rs3768617 0.510 rs6424885 chr1:183066254 T/G ch.1.3577855R chr1:183094577 LAMC1 0.88 14.24 0.66 1.45e-34 Fuchs's corneal dystrophy; CESC cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg22875332 chr1:76189707 ACADM 0.58 5.72 0.33 2.83e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg14393609 chr7:65229607 NA 0.51 6.63 0.38 1.82e-10 Aortic root size; CESC cis rs911555 0.755 rs7148567 chr14:103882234 C/T cg09975044 chr14:104007538 NA 0.45 5.62 0.33 4.78e-8 Intelligence (multi-trait analysis); CESC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.03 0.4 1.71e-11 Bipolar disorder; CESC trans rs61931739 0.517 rs1197562 chr12:34122037 G/A cg26384229 chr12:38710491 ALG10B 0.49 6.66 0.38 1.55e-10 Morning vs. evening chronotype; CESC cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg11764359 chr7:65958608 NA 0.82 9.71 0.51 2.93e-19 Aortic root size; CESC cis rs6545883 0.894 rs2694642 chr2:61596180 A/G cg15711740 chr2:61764176 XPO1 0.4 5.07 0.3 7.63e-7 Tuberculosis; CESC cis rs7107174 1.000 rs10899451 chr11:77991222 A/C cg02023728 chr11:77925099 USP35 0.48 6.39 0.37 7.22e-10 Testicular germ cell tumor; CESC cis rs765787 0.530 rs2413775 chr15:45544288 T/A cg24006582 chr15:45444508 DUOX1 -0.59 -7.12 -0.4 9.9e-12 Uric acid levels; CESC trans rs7937682 0.855 rs7934922 chr11:111500026 T/C cg18187862 chr3:45730750 SACM1L 0.51 6.5 0.37 3.97e-10 Primary sclerosing cholangitis; CESC cis rs754133 0.507 rs10876531 chr12:54443718 A/C cg10005224 chr12:54424964 HOXC4;HOXC5 0.33 5.56 0.32 6.65e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index; CESC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg26338869 chr17:61819248 STRADA 0.67 8.77 0.47 2.24e-16 Prudent dietary pattern; CESC cis rs9929218 0.954 rs35444713 chr16:68824492 C/T cg02972257 chr16:68554789 NA 0.5 5.67 0.33 3.64e-8 Colorectal cancer; CESC cis rs1267303 0.563 rs2486163 chr1:47004680 T/C cg25110126 chr1:46999211 NA 0.86 10.82 0.55 7.89e-23 Monobrow; CESC cis rs3126085 0.515 rs10788835 chr1:152330945 T/C cg03465714 chr1:152285911 FLG 0.4 5.15 0.3 5.16e-7 Atopic dermatitis; CESC cis rs858239 0.601 rs10239760 chr7:23149950 C/T cg23682824 chr7:23144976 KLHL7 0.46 6.0 0.35 6.55e-9 Cerebrospinal fluid biomarker levels; CESC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg14829155 chr15:31115871 NA -0.72 -9.75 -0.51 2.15e-19 Huntington's disease progression; CESC cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7605827 0.930 rs6720900 chr2:15688281 T/C cg19274914 chr2:15703543 NA 0.36 6.39 0.37 7.29e-10 Educational attainment (years of education); CESC cis rs11785400 0.701 rs9297967 chr8:143723002 A/C cg24634471 chr8:143751801 JRK 0.43 5.57 0.32 6.39e-8 Schizophrenia; CESC cis rs10751667 0.643 rs10902237 chr11:944801 C/A cg20946044 chr11:1010712 AP2A2 -0.39 -5.32 -0.31 2.22e-7 Alzheimer's disease (late onset); CESC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg00684032 chr4:1343700 KIAA1530 0.42 5.93 0.34 9.41e-9 Obesity-related traits; CESC cis rs763121 0.853 rs2072795 chr22:39064209 A/G cg06022373 chr22:39101656 GTPBP1 -0.88 -14.01 -0.65 9.39e-34 Menopause (age at onset); CESC trans rs9325144 0.560 rs11183189 chr12:38683770 T/A cg23762105 chr12:34175262 ALG10 -0.46 -6.24 -0.36 1.69e-9 Morning vs. evening chronotype; CESC cis rs1499972 0.618 rs56255439 chr3:117651366 C/A cg07612923 chr3:117604196 NA 0.68 6.16 0.35 2.74e-9 Schizophrenia; CESC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg27125505 chr17:43679177 LOC644172 0.5 6.82 0.39 6.04e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg16145915 chr7:1198662 ZFAND2A -0.54 -6.79 -0.38 7.32e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 9.43 0.5 2.11e-18 Platelet count; CESC cis rs11690935 0.550 rs7584187 chr2:172866105 A/G cg13550731 chr2:172543902 DYNC1I2 -0.46 -6.35 -0.36 9.19e-10 Schizophrenia; CESC cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.32 -5.07 -0.3 7.5e-7 Personality dimensions; CESC cis rs2299587 0.554 rs7815429 chr8:17737357 T/C cg08627089 chr8:17753878 FGL1 -0.39 -5.63 -0.33 4.49e-8 Economic and political preferences; CESC cis rs258892 0.895 rs34653 chr5:72146480 A/G cg21869765 chr5:72125136 TNPO1 0.43 5.5 0.32 9.01e-8 Small cell lung carcinoma; CESC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.6 7.48 0.42 1.07e-12 Height; CESC cis rs13102973 0.965 rs13129208 chr4:135858263 A/G cg14419869 chr4:135874104 NA 0.33 5.14 0.3 5.24e-7 Subjective well-being; CESC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg10691866 chr7:65817282 TPST1 -0.34 -5.51 -0.32 8.3e-8 Aortic root size; CESC cis rs9788682 1.000 rs12441426 chr15:78812329 T/C cg24631222 chr15:78858424 CHRNA5 0.76 9.52 0.5 1.13e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11450715 chr2:171627404 NA 0.66 8.03 0.44 3.17e-14 Gut microbiome composition (summer); CESC cis rs782590 0.967 rs62165173 chr2:55741666 T/C cg18811423 chr2:55921094 PNPT1 0.79 12.44 0.61 2.79e-28 Metabolic syndrome; CESC cis rs116095464 0.558 rs1812843 chr5:267658 A/G cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.51e-10 Breast cancer; CESC cis rs2273669 0.667 rs4527738 chr6:109309150 T/C cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC cis rs11958404 0.615 rs10053795 chr5:157449185 T/C cg05962755 chr5:157440814 NA 0.38 5.47 0.32 1.05e-7 IgG glycosylation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25936770 chr7:122321411 CADPS2 -0.51 -7.2 -0.4 6.28e-12 Gut microbiota (bacterial taxa); CESC cis rs2652822 0.525 rs17828874 chr15:63516266 C/G cg02713581 chr15:63449717 RPS27L -0.48 -6.24 -0.36 1.73e-9 Metabolic traits; CESC cis rs2952156 0.920 rs12150298 chr17:37834541 T/C cg00129232 chr17:37814104 STARD3 -0.73 -10.54 -0.54 6.53e-22 Asthma; CESC cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg05347473 chr6:146136440 FBXO30 0.55 7.06 0.4 1.45e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.657 rs4463052 chr4:120313258 T/C cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg01396998 chr7:76181996 LOC100133091 0.42 6.17 0.35 2.57e-9 Prevalent atrial fibrillation; CESC cis rs11030122 0.592 rs4910880 chr11:4084630 C/G cg18678763 chr11:4115507 RRM1 -0.45 -6.19 -0.36 2.26e-9 Mean platelet volume;Platelet distribution width; CESC trans rs7615952 0.609 rs13088451 chr3:125553499 G/C cg07211511 chr3:129823064 LOC729375 -0.92 -10.87 -0.56 5.45e-23 Blood pressure (smoking interaction); CESC cis rs28647808 1.000 rs7032021 chr9:136276601 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs2487048 0.804 rs2472496 chr9:107695353 C/T cg14470647 chr9:107690075 ABCA1 -0.44 -5.21 -0.31 3.71e-7 Intraocular pressure; CESC cis rs1552244 0.608 rs3732962 chr3:10048951 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -7.27 -0.41 4.1e-12 Alzheimer's disease; CESC cis rs3008870 1.000 rs3008888 chr1:67368965 C/T cg02640540 chr1:67518911 SLC35D1 0.49 5.31 0.31 2.33e-7 Lymphocyte percentage of white cells; CESC cis rs7633770 0.710 rs4683259 chr3:46698538 A/G cg11219411 chr3:46661640 NA -0.32 -5.03 -0.3 9.14e-7 Coronary artery disease; CESC cis rs7582720 1.000 rs72934505 chr2:203916487 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.84 7.1 0.4 1.13e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs13102973 0.931 rs13103718 chr4:135843990 C/T cg14419869 chr4:135874104 NA 0.34 5.25 0.31 3.11e-7 Subjective well-being; CESC cis rs6500395 0.775 rs7191225 chr16:48662675 C/G cg04672837 chr16:48644449 N4BP1 0.5 6.49 0.37 4.09e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs10870270 1.000 rs72636963 chr10:133771271 C/T cg08754478 chr10:133766260 PPP2R2D -0.6 -7.65 -0.43 3.77e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs6088580 0.634 rs2378133 chr20:32919505 C/G cg24642439 chr20:33292090 TP53INP2 -0.51 -6.65 -0.38 1.63e-10 Glomerular filtration rate (creatinine); CESC cis rs13191362 0.507 rs13207363 chr6:163201285 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.5 -5.79 -0.33 2.03e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4237845 0.513 rs7134797 chr12:58263852 C/T cg00677455 chr12:58241039 CTDSP2 0.79 10.41 0.54 1.66e-21 Intelligence (multi-trait analysis); CESC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg07507251 chr3:52567010 NT5DC2 0.32 5.58 0.32 5.93e-8 Bipolar disorder; CESC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg12463550 chr7:65579703 CRCP -0.54 -6.65 -0.38 1.65e-10 Aortic root size; CESC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg11890956 chr21:40555474 PSMG1 1.21 23.76 0.82 1.3e-67 Cognitive function; CESC cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg21573476 chr21:45109991 RRP1B -0.48 -6.71 -0.38 1.19e-10 Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14903685 chr15:70391316 TLE3 -0.46 -6.16 -0.35 2.72e-9 Fibrinogen levels; CESC cis rs920590 0.758 rs17091534 chr8:19670651 C/T cg03894339 chr8:19674705 INTS10 0.64 7.38 0.41 2.01e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs67478160 0.704 rs12894254 chr14:104290949 G/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.13 -0.4 9.71e-12 Schizophrenia; CESC cis rs6088580 0.524 rs4911437 chr20:33266149 G/T cg08999081 chr20:33150536 PIGU -0.37 -5.03 -0.3 8.96e-7 Glomerular filtration rate (creatinine); CESC cis rs2204008 0.627 rs10878488 chr12:38148666 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.67 0.38 1.48e-10 Bladder cancer; CESC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg14393609 chr7:65229607 NA 0.5 6.46 0.37 4.93e-10 Aortic root size; CESC cis rs838147 0.537 rs632111 chr19:49208978 A/G cg21064579 chr19:49206444 FUT2 0.51 7.21 0.4 5.87e-12 Dietary macronutrient intake; CESC cis rs9916302 0.821 rs11078916 chr17:37746307 T/C cg07936489 chr17:37558343 FBXL20 -0.76 -10.1 -0.53 1.65e-20 Glomerular filtration rate (creatinine); CESC cis rs11711311 0.824 rs9876528 chr3:113357196 G/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.62 8.05 0.44 2.87e-14 IgG glycosylation; CESC cis rs6587515 0.901 rs7520516 chr1:150659695 C/G cg13175981 chr1:150552382 MCL1 0.62 5.65 0.33 4.23e-8 Pericardial adipose tissue adjusted for height and weight; CESC cis rs4132509 0.947 rs10927039 chr1:243721726 C/T cg21452805 chr1:244014465 NA -0.45 -5.69 -0.33 3.37e-8 RR interval (heart rate); CESC cis rs9894429 0.624 rs9910935 chr17:79613949 T/C cg18240062 chr17:79603768 NPLOC4 0.8 10.72 0.55 1.6e-22 Eye color traits; CESC cis rs2066819 0.786 rs111580405 chr12:56739557 A/G cg26734620 chr12:56694298 CS 0.98 5.95 0.34 8.45e-9 Psoriasis vulgaris; CESC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg05863683 chr7:1912471 MAD1L1 0.38 5.45 0.32 1.16e-7 Bipolar disorder and schizophrenia; CESC cis rs1178968 0.901 rs2528705 chr7:72791238 A/G cg25889504 chr7:72793014 NA 0.52 5.58 0.32 5.95e-8 Triglyceride levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00717482 chr1:112531938 KCND3 -0.46 -6.06 -0.35 4.65e-9 Fibrinogen levels; CESC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg23283495 chr1:209979779 IRF6 0.48 5.73 0.33 2.78e-8 Cleft lip with or without cleft palate; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg14147105 chr19:17531148 FAM125A 0.49 6.46 0.37 5.07e-10 Systemic lupus erythematosus; CESC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg13770153 chr20:60521292 NA -0.44 -5.71 -0.33 3.02e-8 Body mass index; CESC cis rs2243480 0.901 rs35823062 chr7:65965821 A/G cg18252515 chr7:66147081 NA -1.4 -14.33 -0.66 7.01e-35 Diabetic kidney disease; CESC cis rs10504229 0.679 rs16921687 chr8:58053514 T/C cg02725872 chr8:58115012 NA -0.33 -5.04 -0.3 8.84e-7 Developmental language disorder (linguistic errors); CESC trans rs5756813 0.754 rs11705616 chr22:38180487 G/T cg19894588 chr14:64061835 NA -0.65 -8.27 -0.45 6.52e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs8114671 0.562 rs6120763 chr20:33506400 C/G cg06115741 chr20:33292138 TP53INP2 0.46 5.58 0.32 6.06e-8 Height; CESC cis rs7580658 0.895 rs4662722 chr2:128102569 T/C cg10021288 chr2:128175891 PROC -0.41 -6.46 -0.37 5.11e-10 Protein C levels; CESC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg22968622 chr17:43663579 NA 0.77 10.69 0.55 2.1e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg18876405 chr7:65276391 NA 0.69 9.64 0.51 4.96e-19 Aortic root size; CESC cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg19539972 chr4:7069911 GRPEL1 -0.67 -7.05 -0.4 1.59e-11 Monocyte percentage of white cells; CESC cis rs796364 0.951 rs12463436 chr2:201061962 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.61 6.36 0.36 8.55e-10 Schizophrenia; CESC cis rs9790314 0.580 rs960212 chr3:161047974 C/T cg03342759 chr3:160939853 NMD3 -0.45 -6.57 -0.37 2.59e-10 Morning vs. evening chronotype; CESC cis rs117623576 0.618 rs211416 chr10:32397591 T/A cg03047570 chr10:32398778 NA 0.66 7.29 0.41 3.65e-12 Anti-saccade response; CESC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.7 7.96 0.44 4.98e-14 Gut microbiome composition (summer); CESC cis rs2797160 1.000 rs1739376 chr6:126012084 C/G cg05901451 chr6:126070800 HEY2 0.47 6.36 0.36 8.56e-10 Endometrial cancer; CESC cis rs7274811 0.625 rs293725 chr20:31929643 C/G cg21523528 chr20:32077966 CBFA2T2 -0.46 -5.16 -0.3 4.87e-7 Height; CESC cis rs1185460 0.967 rs1784460 chr11:118938371 A/T cg01677386 chr11:118938358 VPS11 0.46 6.18 0.35 2.46e-9 Coronary artery disease; CESC cis rs55728055 0.661 rs55648708 chr22:32032062 G/A cg01338084 chr22:32026380 PISD 1.12 7.87 0.44 9.3e-14 Age-related hearing impairment; CESC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg11764359 chr7:65958608 NA 0.7 9.23 0.49 8.79e-18 Aortic root size; CESC cis rs4664308 1.000 rs10929965 chr2:160906931 C/T cg03641300 chr2:160917029 PLA2R1 0.66 10.16 0.53 1.1e-20 Idiopathic membranous nephropathy; CESC cis rs10883723 0.810 rs7093028 chr10:104259417 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs7091068 0.518 rs9633674 chr10:95455431 C/T cg20715218 chr10:95462985 C10orf4 0.5 6.41 0.37 6.46e-10 Urinary tract infection frequency; CESC cis rs6582630 0.555 rs11181684 chr12:38388000 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.88 0.34 1.23e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs7617773 0.780 rs35411187 chr3:48360017 C/G cg11946769 chr3:48343235 NME6 0.89 12.34 0.6 5.98e-28 Coronary artery disease; CESC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg13902645 chr11:5959945 NA -0.64 -9.09 -0.49 2.36e-17 DNA methylation (variation); CESC cis rs11098499 0.863 rs3822194 chr4:120471648 A/G cg24375607 chr4:120327624 NA 0.43 5.32 0.31 2.16e-7 Corneal astigmatism; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18510056 chr10:77163383 C10orf41 0.39 6.23 0.36 1.82e-9 Gambling; CESC cis rs7527798 0.592 rs12025522 chr1:207854355 A/C cg21110645 chr1:207815933 NA 0.32 5.81 0.34 1.83e-8 Erythrocyte sedimentation rate; CESC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg04317338 chr11:64019027 PLCB3 0.87 9.06 0.49 3.04e-17 Mean platelet volume; CESC cis rs6912958 1.000 rs2223880 chr6:88167897 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.41 -0.46 2.5e-15 Monocyte percentage of white cells; CESC cis rs2522056 1.000 rs2522062 chr5:131805416 A/G cg24060327 chr5:131705240 SLC22A5 0.61 6.93 0.39 3.22e-11 Lymphocyte counts;Fibrinogen; CESC cis rs11252926 0.545 rs11252693 chr10:532139 A/G cg16386425 chr10:429943 DIP2C -0.43 -5.63 -0.33 4.65e-8 Psychosis in Alzheimer's disease; CESC cis rs1568889 0.838 rs4614434 chr11:28302234 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.99 0.65 1.11e-33 Bipolar disorder; CESC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg10691866 chr7:65817282 TPST1 0.35 5.78 0.33 2.13e-8 Aortic root size; CESC cis rs2072499 0.868 rs2758600 chr1:156195205 C/T cg24450063 chr1:156163899 SLC25A44 0.93 14.21 0.66 1.84e-34 Testicular germ cell tumor; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25179170 chr1:93427589 FAM69A -0.44 -6.25 -0.36 1.62e-9 Gambling; CESC cis rs637571 0.522 rs491973 chr11:65727301 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.74 10.78 0.55 1.01e-22 Eosinophil percentage of white cells; CESC cis rs2950393 0.857 rs9989034 chr12:57068292 C/T cg05584118 chr12:57595605 LRP1 -0.37 -5.25 -0.31 3.16e-7 Platelet distribution width; CESC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg06108461 chr20:60628389 TAF4 -0.94 -14.7 -0.67 3.53e-36 Body mass index; CESC cis rs7843479 0.601 rs9969551 chr8:21860007 T/C cg17168535 chr8:21777572 XPO7 0.73 11.4 0.57 9.24e-25 Mean corpuscular volume; CESC cis rs727505 1.000 rs10233596 chr7:124556659 A/G cg23710748 chr7:124431027 NA -0.48 -7.46 -0.42 1.27e-12 Lewy body disease; CESC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg18252515 chr7:66147081 NA 0.43 5.66 0.33 3.97e-8 Aortic root size; CESC cis rs1595825 0.891 rs60582020 chr2:198520555 A/C cg10820045 chr2:198174542 NA 0.41 5.21 0.3 3.79e-7 Ulcerative colitis; CESC cis rs1144333 0.655 rs1144337 chr1:76278877 A/G cg10523679 chr1:76189770 ACADM -0.57 -5.48 -0.32 9.94e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs3749237 0.537 rs4459909 chr3:49469217 T/C cg07636037 chr3:49044803 WDR6 0.64 9.27 0.49 6.68e-18 Resting heart rate; CESC cis rs1707322 1.000 rs1707322 chr1:46505147 C/T cg03146154 chr1:46216737 IPP 0.75 10.34 0.54 2.93e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9291683 0.609 rs36084205 chr4:10028678 A/C cg00071950 chr4:10020882 SLC2A9 0.89 16.34 0.71 5.39e-42 Bone mineral density; CESC cis rs8067354 0.645 rs2645467 chr17:57854783 C/T cg13753209 chr17:57696993 CLTC 0.65 8.23 0.45 8.42e-15 Hemoglobin concentration; CESC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg11764359 chr7:65958608 NA -0.92 -14.72 -0.67 2.89e-36 Aortic root size; CESC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg13733410 chr7:12443478 VWDE -0.53 -5.45 -0.32 1.17e-7 Coronary artery disease; CESC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.92 0.52 6.18e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.55 0.58 2.95e-25 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07396495 chr16:53468716 RBL2 0.63 8.08 0.44 2.37e-14 Gut microbiome composition (summer); CESC cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg11502198 chr6:26597334 ABT1 0.49 5.18 0.3 4.47e-7 Intelligence (multi-trait analysis); CESC cis rs698833 0.892 rs698796 chr2:44689669 C/A cg04920474 chr2:44395004 PPM1B 0.36 5.08 0.3 6.98e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg14298792 chr15:30685198 CHRFAM7A 0.47 5.61 0.33 5.13e-8 Huntington's disease progression; CESC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg18357526 chr6:26021779 HIST1H4A -0.68 -9.39 -0.5 2.89e-18 Intelligence (multi-trait analysis); CESC cis rs12136530 0.806 rs10917451 chr1:19769323 G/C cg01832549 chr1:19774989 CAPZB -0.48 -6.66 -0.38 1.6e-10 Lead levels in blood; CESC trans rs451417 1.000 rs384578 chr20:5981476 A/G cg17614506 chr7:47803072 NA 0.57 6.03 0.35 5.6e-9 Menopause (age at onset); CESC cis rs6430585 0.528 rs56064699 chr2:136595706 G/A cg07169764 chr2:136633963 MCM6 1.34 18.28 0.75 7.53e-49 Corneal structure; CESC cis rs7927592 0.913 rs7102898 chr11:68328870 G/A cg20283391 chr11:68216788 NA -0.61 -7.36 -0.41 2.26e-12 Total body bone mineral density; CESC cis rs116095464 0.558 rs7730700 chr5:264713 G/A cg20965017 chr5:231967 SDHA -0.48 -5.43 -0.32 1.25e-7 Breast cancer; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg13030908 chr1:11741533 MAD2L2 0.47 6.14 0.35 2.93e-9 Tetralogy of Fallot; CESC cis rs6088580 0.634 rs4911151 chr20:32932273 T/C cg24642439 chr20:33292090 TP53INP2 -0.52 -6.78 -0.38 7.99e-11 Glomerular filtration rate (creatinine); CESC cis rs72945132 0.882 rs11235953 chr11:70184937 C/T cg00319359 chr11:70116639 PPFIA1 0.71 6.92 0.39 3.49e-11 Coronary artery disease; CESC cis rs9916302 0.706 rs8182252 chr17:37727950 T/C cg20243544 chr17:37824526 PNMT -0.53 -5.88 -0.34 1.22e-8 Glomerular filtration rate (creatinine); CESC cis rs644148 0.730 rs2571044 chr19:44985573 G/A cg15540054 chr19:45004280 ZNF180 -0.59 -6.38 -0.37 7.68e-10 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19393587 chr2:70106252 GMCL1 -0.54 -6.41 -0.37 6.46e-10 Gut microbiome composition (summer); CESC cis rs7824557 1.000 rs7824557 chr8:11104111 C/T cg21775007 chr8:11205619 TDH -0.42 -6.23 -0.36 1.86e-9 Retinal vascular caliber; CESC cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.09 0.3 6.84e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg13880726 chr7:1868755 MAD1L1 0.51 6.72 0.38 1.11e-10 Bipolar disorder and schizophrenia; CESC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg23281280 chr6:28129359 ZNF389 -0.46 -6.22 -0.36 1.9e-9 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01737507 chr5:122372093 PPIC 0.54 6.56 0.37 2.88e-10 Gut microbiome composition (summer); CESC cis rs7267979 0.868 rs6138550 chr20:25223430 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.6 0.69 2.21e-39 Liver enzyme levels (alkaline phosphatase); CESC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.68 0.64 1.42e-32 Prudent dietary pattern; CESC cis rs634534 0.622 rs531612 chr11:65705432 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.4 -5.72 -0.33 2.87e-8 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs72945132 0.882 rs56176527 chr11:70162513 A/G cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg05564831 chr3:52568323 NT5DC2 0.45 6.8 0.39 6.82e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07911682 chr1:51425659 FAF1 0.62 7.65 0.43 3.71e-13 Gut microbiome composition (summer); CESC cis rs3857536 0.740 rs7763555 chr6:66889930 C/T cg07460842 chr6:66804631 NA -0.42 -5.39 -0.31 1.56e-7 Blood trace element (Cu levels); CESC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg18099408 chr3:52552593 STAB1 -0.32 -5.51 -0.32 8.55e-8 Electroencephalogram traits; CESC cis rs950776 0.518 rs12910289 chr15:78822065 T/G cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs524281 0.861 rs7937281 chr11:65950074 T/C cg14036092 chr11:66035641 RAB1B -0.48 -5.17 -0.3 4.61e-7 Electroencephalogram traits; CESC cis rs425277 1.000 rs425277 chr1:2069172 C/T cg04315214 chr1:2043799 PRKCZ -0.41 -5.81 -0.34 1.82e-8 Height; CESC cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.82 6.91 0.39 3.58e-11 Initial pursuit acceleration; CESC cis rs6582630 0.519 rs1607868 chr12:38385512 G/T cg26384229 chr12:38710491 ALG10B 0.71 10.82 0.55 7.95e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg12963246 chr6:28129442 ZNF389 0.54 7.18 0.4 6.92e-12 Depression; CESC cis rs4253772 0.513 rs9615345 chr22:46713631 C/T cg00784671 chr22:46762841 CELSR1 -0.39 -5.07 -0.3 7.53e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7267979 0.903 rs6115109 chr20:25239667 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.09 0.68 1.41e-37 Liver enzyme levels (alkaline phosphatase); CESC cis rs6662572 0.806 rs12047498 chr1:45954632 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.53 5.74 0.33 2.56e-8 Blood protein levels; CESC cis rs2250402 0.510 rs2291621 chr15:40324837 C/T cg16127683 chr15:40268777 EIF2AK4 -0.61 -5.42 -0.32 1.32e-7 Corneal curvature; CESC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg07395648 chr5:131743802 NA -0.44 -5.64 -0.33 4.32e-8 Breast cancer;Mosquito bite size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11905814 chr11:46639029 KIAA0652;HARBI1 -0.5 -6.17 -0.35 2.57e-9 Ulcerative colitis; CESC cis rs7602441 0.521 rs77940955 chr2:14767411 T/C cg06545361 chr2:14773388 FAM84A 0.69 6.69 0.38 1.34e-10 Visceral adipose tissue adjusted for BMI; CESC cis rs72781680 0.652 rs12618900 chr2:23910775 C/T cg08917208 chr2:24149416 ATAD2B 1.22 10.51 0.54 8.13e-22 Lymphocyte counts; CESC cis rs7178572 0.568 rs7177533 chr15:77387923 C/T cg22256960 chr15:77711686 NA -0.5 -6.14 -0.35 2.96e-9 Type 2 diabetes; CESC cis rs3091242 0.933 rs11249251 chr1:25770188 C/G cg02931644 chr1:25747376 RHCE 0.39 6.6 0.38 2.19e-10 Erythrocyte sedimentation rate; CESC cis rs9527 0.544 rs11191549 chr10:104846797 C/T cg04362960 chr10:104952993 NT5C2 0.44 5.61 0.33 4.97e-8 Arsenic metabolism; CESC cis rs919433 0.927 rs1429418 chr2:198158151 G/C cg10820045 chr2:198174542 NA -0.37 -5.13 -0.3 5.73e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2294693 0.679 rs4317403 chr6:40971173 C/T cg14769373 chr6:40998127 UNC5CL -0.43 -5.27 -0.31 2.84e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs4819052 0.679 rs2838860 chr21:46684904 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.68 0.33 3.45e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6963495 0.651 rs3892298 chr7:105152187 A/G cg02135003 chr7:105160482 PUS7 -0.46 -5.46 -0.32 1.08e-7 Bipolar disorder (body mass index interaction); CESC cis rs990171 0.571 rs3771202 chr2:102772669 C/G cg22835712 chr2:102737379 NA 0.43 5.83 0.34 1.64e-8 Lymphocyte counts; CESC trans rs12339966 0.689 rs3001252 chr9:11680323 G/A cg03904639 chr13:37677730 CSNK1A1L 0.39 5.99 0.35 6.65e-9 Systolic blood pressure; CESC cis rs17854409 0.881 rs1046784 chr20:61472808 G/C cg05147244 chr20:61493195 TCFL5 0.97 6.63 0.38 1.88e-10 Obesity-related traits; CESC trans rs61931739 0.534 rs11053072 chr12:34202399 A/C cg26384229 chr12:38710491 ALG10B 0.64 9.15 0.49 1.59e-17 Morning vs. evening chronotype; CESC cis rs9611565 0.568 rs5758441 chr22:42132888 C/A cg06634786 chr22:41940651 POLR3H 0.49 5.5 0.32 8.83e-8 Vitiligo; CESC cis rs4728302 0.869 rs6963032 chr7:133599527 T/C cg10665199 chr7:133106180 EXOC4 0.42 5.93 0.34 9.21e-9 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7100689 0.646 rs10736356 chr10:82148325 A/G cg00277334 chr10:82204260 NA -0.59 -7.69 -0.43 2.82e-13 Post bronchodilator FEV1; CESC cis rs910316 0.712 rs175037 chr14:75465038 T/C cg11812906 chr14:75593930 NEK9 -0.81 -13.34 -0.63 2.05e-31 Height; CESC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg04944784 chr2:26401820 FAM59B 0.75 8.12 0.45 1.79e-14 Gut microbiome composition (summer); CESC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg07507251 chr3:52567010 NT5DC2 0.38 6.04 0.35 5.06e-9 Bipolar disorder; CESC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg24549020 chr5:56110836 MAP3K1 0.66 7.46 0.42 1.23e-12 Initial pursuit acceleration; CESC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.7 0.43 2.77e-13 Prudent dietary pattern; CESC cis rs6088590 0.965 rs910869 chr20:33292777 C/T cg24642439 chr20:33292090 TP53INP2 0.87 12.04 0.59 6.42e-27 Coronary artery disease; CESC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg08888203 chr3:10149979 C3orf24 0.48 6.16 0.35 2.73e-9 Alzheimer's disease; CESC cis rs9894429 0.789 rs7502346 chr17:79603741 T/C cg21984481 chr17:79567631 NPLOC4 -0.57 -9.11 -0.49 2.03e-17 Eye color traits; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg26512142 chr11:2554198 KCNQ1 0.48 6.83 0.39 5.92e-11 Systemic lupus erythematosus; CESC cis rs2204008 0.805 rs12146846 chr12:37985847 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.92 0.56 3.59e-23 Bladder cancer; CESC cis rs7845219 0.544 rs10956930 chr8:95919786 C/G cg09323728 chr8:95962352 TP53INP1 -0.32 -6.23 -0.36 1.8e-9 Type 2 diabetes; CESC cis rs832540 0.593 rs252912 chr5:56195792 C/T cg14703610 chr5:56206110 C5orf35 0.46 5.75 0.33 2.42e-8 Coronary artery disease; CESC cis rs9929218 0.559 rs55907909 chr16:68805805 C/T cg02972257 chr16:68554789 NA -0.42 -5.25 -0.31 3.17e-7 Colorectal cancer; CESC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.27 0.31 2.88e-7 Tonsillectomy; CESC cis rs751837 0.591 rs2285013 chr14:103429825 A/G cg10087771 chr14:103399429 CDC42BPB 0.61 5.67 0.33 3.66e-8 Large B-cell lymphoma; CESC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg06600287 chr1:53387719 ECHDC2 0.27 5.16 0.3 4.92e-7 Monocyte count; CESC cis rs17655565 0.636 rs17119838 chr12:52716596 C/T cg08257133 chr12:52711352 KRT83 0.37 5.22 0.31 3.58e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs902774 0.515 rs2363635 chr12:53354622 T/C cg25025879 chr12:53359317 NA -0.53 -6.91 -0.39 3.59e-11 Prostate cancer; CESC cis rs5753618 0.583 rs8138596 chr22:31786961 T/A cg00478049 chr22:31556069 RNF185 -0.43 -5.04 -0.3 8.52e-7 Colorectal cancer; CESC cis rs258892 0.895 rs394274 chr5:72135955 C/T cg21869765 chr5:72125136 TNPO1 0.44 5.68 0.33 3.61e-8 Small cell lung carcinoma; CESC cis rs35955747 0.633 rs5998012 chr22:31889844 G/A cg25791279 chr22:32026902 PISD -0.44 -5.14 -0.3 5.38e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg18190219 chr22:46762943 CELSR1 -0.59 -6.57 -0.37 2.66e-10 LDL cholesterol;Cholesterol, total; CESC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg23534315 chr17:78082725 GAA 0.37 5.27 0.31 2.88e-7 Yeast infection; CESC cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg10556349 chr10:835070 NA 0.72 6.12 0.35 3.39e-9 Eosinophil percentage of granulocytes; CESC cis rs722599 0.683 rs2058918 chr14:75288518 A/G cg11812906 chr14:75593930 NEK9 0.45 5.41 0.32 1.39e-7 IgG glycosylation; CESC cis rs2735413 0.918 rs12598024 chr16:78079114 G/A cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg18446336 chr7:2847575 GNA12 -0.34 -5.15 -0.3 5.13e-7 Height; CESC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg12963246 chr6:28129442 ZNF389 0.5 6.4 0.37 6.93e-10 Parkinson's disease; CESC cis rs7586673 0.866 rs747003 chr2:161916409 C/T cg08807892 chr2:162101083 NA -0.46 -6.24 -0.36 1.75e-9 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16435601 chr17:65822392 BPTF -0.47 -6.28 -0.36 1.35e-9 Fibrinogen levels; CESC cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg20503657 chr10:835505 NA 0.78 7.72 0.43 2.41e-13 Eosinophil percentage of granulocytes; CESC cis rs6580649 0.943 rs9651993 chr12:48404692 G/A cg05342945 chr12:48394962 COL2A1 -0.57 -6.62 -0.38 1.95e-10 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05236446 chr14:73524740 RBM25 -0.52 -6.04 -0.35 5.25e-9 Gut microbiome composition (summer); CESC cis rs7605827 0.930 rs1996517 chr2:15517330 T/C cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs1986734 0.555 rs12500824 chr4:77416627 A/G cg20311846 chr4:77356250 SHROOM3 -0.29 -5.8 -0.34 1.84e-8 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00903375 chr7:66460591 SBDS;TYW1 0.51 6.68 0.38 1.41e-10 Gut microbiota (bacterial taxa); CESC cis rs10788972 0.815 rs9651202 chr1:54553207 T/C cg25741118 chr1:54482237 LDLRAD1 -0.22 -5.25 -0.31 3.19e-7 Parkinson disease and lewy body pathology; CESC cis rs1448094 0.617 rs4842569 chr12:86468609 T/G cg02569458 chr12:86230093 RASSF9 -0.35 -5.17 -0.3 4.66e-7 Major depressive disorder; CESC cis rs8060686 0.920 rs111315946 chr16:67889793 G/C cg26727032 chr16:67993705 SLC12A4 -0.57 -6.11 -0.35 3.47e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs662064 0.748 rs2506889 chr1:10596022 C/T cg20482658 chr1:10539492 PEX14 0.41 8.38 0.46 3.21e-15 Asthma; CESC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg17372223 chr3:52568218 NT5DC2 0.43 6.36 0.36 9.03e-10 Bipolar disorder; CESC cis rs34779708 0.931 rs11010083 chr10:35351531 C/G cg03585969 chr10:35415529 CREM 0.76 9.88 0.52 8.46e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -5.7 -0.33 3.12e-8 Extrinsic epigenetic age acceleration; CESC cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg08213375 chr14:104286397 PPP1R13B 0.33 5.38 0.31 1.62e-7 Reticulocyte count; CESC cis rs2050392 1.000 rs2480280 chr10:30696092 A/G cg18806716 chr10:30721971 MAP3K8 -0.4 -5.83 -0.34 1.58e-8 Inflammatory bowel disease; CESC cis rs2228479 0.850 rs62054257 chr16:89900195 G/A cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg12826209 chr6:26865740 GUSBL1 0.77 9.33 0.5 4.38e-18 Intelligence (multi-trait analysis); CESC cis rs9911578 1.000 rs8071916 chr17:56660279 A/G cg12560992 chr17:57184187 TRIM37 0.93 15.87 0.7 2.55e-40 Intelligence (multi-trait analysis); CESC cis rs1670533 0.932 rs3796620 chr4:1095079 A/G cg04106633 chr4:1044584 NA -0.4 -5.16 -0.3 4.94e-7 Recombination rate (females); CESC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.19 0.53 8.59e-21 Prudent dietary pattern; CESC cis rs2737618 0.551 rs2816989 chr1:200070765 G/T cg21825944 chr1:200113062 NR5A2 0.39 5.57 0.32 6.12e-8 Uric acid levels; CESC cis rs7923452 1.000 rs7923452 chr10:30751171 T/C cg25182066 chr10:30743637 MAP3K8 0.5 5.57 0.32 6.34e-8 Itch intensity from mosquito bite; CESC cis rs7599312 0.534 rs6735626 chr2:213403972 G/A cg16329650 chr2:213403929 ERBB4 0.58 8.43 0.46 2.31e-15 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2502731 0.561 rs3003606 chr9:130982416 C/T cg09976142 chr9:130955436 CIZ1 0.39 6.34 0.36 9.84e-10 Attention deficit hyperactivity disorder; CESC cis rs6456156 0.586 rs12525855 chr6:167480013 T/G cg23791538 chr6:167370224 RNASET2 -0.53 -6.91 -0.39 3.59e-11 Primary biliary cholangitis; CESC cis rs17270561 0.583 rs12662869 chr6:25784481 A/C cg25753631 chr6:25732923 NA 0.28 5.47 0.32 1.02e-7 Iron status biomarkers; CESC cis rs11997175 0.646 rs6468197 chr8:33734894 G/T ch.8.33884649F chr8:33765107 NA 0.56 7.05 0.4 1.58e-11 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11321298 chr22:40766510 SGSM3 -0.56 -6.38 -0.36 7.83e-10 Gut microbiome composition (summer); CESC cis rs7089973 0.604 rs7903663 chr10:116609904 G/A cg03647239 chr10:116582469 FAM160B1 0.41 5.15 0.3 5.11e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs832540 1.000 rs252914 chr5:56198150 A/C cg14703610 chr5:56206110 C5orf35 0.53 6.97 0.39 2.54e-11 Coronary artery disease; CESC cis rs9640161 0.742 rs11767726 chr7:150018096 A/C cg21361702 chr7:150065534 REPIN1 -0.57 -6.82 -0.39 6.27e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs854765 0.583 rs11871899 chr17:17826748 C/G cg04398451 chr17:18023971 MYO15A -0.65 -9.23 -0.49 9.1e-18 Total body bone mineral density; CESC trans rs7839040 0.698 rs7836783 chr8:82928934 C/A cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs3733585 0.699 rs7699609 chr4:9961059 A/G cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs28374715 0.617 rs28626792 chr15:41562218 A/G cg02330683 chr15:41787940 ITPKA 0.36 5.04 0.3 8.78e-7 Ulcerative colitis; CESC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg14393609 chr7:65229607 NA -0.42 -5.86 -0.34 1.35e-8 Aortic root size; CESC cis rs2235642 0.533 rs2667679 chr16:1654946 G/A cg03650551 chr16:1797383 MAPK8IP3 -0.38 -5.29 -0.31 2.57e-7 Coronary artery disease; CESC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg06873352 chr17:61820015 STRADA 0.73 12.86 0.62 9.85e-30 Prudent dietary pattern; CESC cis rs11252926 0.598 rs4881256 chr10:453831 T/A cg16386425 chr10:429943 DIP2C -0.57 -7.3 -0.41 3.29e-12 Psychosis in Alzheimer's disease; CESC cis rs533123 0.818 rs204051 chr1:29166578 A/G cg08366446 chr1:29138936 OPRD1 0.55 5.62 0.33 4.85e-8 Schizophrenia; CESC cis rs2050392 0.687 rs608693 chr10:30734971 G/A cg18806716 chr10:30721971 MAP3K8 -0.47 -6.64 -0.38 1.78e-10 Inflammatory bowel disease; CESC cis rs10883723 0.810 rs7090034 chr10:104281155 C/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.18 0.3 4.34e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs854765 0.583 rs4925123 chr17:17784374 A/G cg09796270 chr17:17721594 SREBF1 -0.45 -6.35 -0.36 9.24e-10 Total body bone mineral density; CESC cis rs7809799 1.000 rs6975245 chr7:98755272 G/T cg05967295 chr7:98741636 SMURF1 -0.75 -5.19 -0.3 4.14e-7 Ulcerative colitis; CESC cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg14345882 chr6:26364793 BTN3A2 0.42 5.29 0.31 2.59e-7 Intelligence (multi-trait analysis); CESC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg21984481 chr17:79567631 NPLOC4 -0.49 -8.04 -0.44 2.97e-14 Eye color traits; CESC cis rs2635047 0.530 rs4986228 chr18:44595259 C/T cg19077165 chr18:44547161 KATNAL2 -0.43 -5.67 -0.33 3.79e-8 Educational attainment; CESC cis rs2180341 0.597 rs11154397 chr6:127646649 G/C cg27446573 chr6:127587934 RNF146 0.63 8.54 0.46 1.09e-15 Breast cancer; CESC cis rs7703051 0.901 rs4704227 chr5:74826735 G/A cg03227963 chr5:74354835 NA 0.29 5.21 0.31 3.73e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg07507251 chr3:52567010 NT5DC2 -0.29 -5.09 -0.3 6.64e-7 Bipolar disorder; CESC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 9.12 0.49 1.99e-17 Platelet count; CESC cis rs9435341 0.965 rs3108680 chr1:107572997 T/C cg09367891 chr1:107599246 PRMT6 0.59 7.19 0.4 6.63e-12 Facial morphology (factor 21, depth of nasal alae); CESC cis rs1538970 0.816 rs10789464 chr1:45959102 C/T cg06784218 chr1:46089804 CCDC17 0.37 5.84 0.34 1.53e-8 Platelet count; CESC cis rs7520050 0.966 rs11211199 chr1:46287869 T/C cg24296786 chr1:45957014 TESK2 0.43 5.42 0.32 1.32e-7 Red blood cell count;Reticulocyte count; CESC cis rs1348850 0.958 rs4528793 chr2:178464271 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.62 0.47 6.11e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9467711 0.606 rs9357006 chr6:26364628 A/C cg12826209 chr6:26865740 GUSBL1 0.62 5.31 0.31 2.27e-7 Autism spectrum disorder or schizophrenia; CESC cis rs11252926 0.650 rs4880678 chr10:490472 G/A cg03684893 chr10:554711 DIP2C -0.42 -6.39 -0.37 7.23e-10 Psychosis in Alzheimer's disease; CESC cis rs933688 1.000 rs12188467 chr5:90765632 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.82 10.4 0.54 1.78e-21 Smoking behavior; CESC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg22920501 chr2:26401640 FAM59B 0.91 10.38 0.54 2.08e-21 Gut microbiome composition (summer); CESC cis rs9291683 0.609 rs36084205 chr4:10028678 A/C cg11266682 chr4:10021025 SLC2A9 0.7 14.15 0.66 2.99e-34 Bone mineral density; CESC cis rs12479064 0.671 rs62155807 chr2:100076579 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -7.28 -0.41 3.69e-12 Chronic sinus infection; CESC trans rs1814175 0.817 rs28544182 chr11:50049577 G/T cg03929089 chr4:120376271 NA -0.94 -16.17 -0.7 2.25e-41 Height; CESC cis rs1003719 1.000 rs2154536 chr21:38492147 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.62 0.47 6.04e-16 Eye color traits; CESC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg18225595 chr11:63971243 STIP1 0.72 9.79 0.52 1.64e-19 Platelet count; CESC cis rs1707322 0.717 rs2991988 chr1:46082431 C/A cg05343316 chr1:45956843 TESK2 -0.53 -6.5 -0.37 3.98e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs897984 0.542 rs73530203 chr16:31099859 G/A cg02466173 chr16:30829666 NA -0.44 -7.27 -0.41 4e-12 Dementia with Lewy bodies; CESC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg20151795 chr6:28129481 ZNF389 0.45 5.84 0.34 1.5e-8 Depression; CESC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 10.49 0.54 9.53e-22 Platelet count; CESC cis rs9287719 0.967 rs6727768 chr2:10757479 T/C cg00105475 chr2:10696890 NA 0.37 5.4 0.31 1.52e-7 Prostate cancer; CESC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg18769074 chr3:133464867 TF 0.32 5.91 0.34 1.06e-8 Iron status biomarkers; CESC cis rs7264396 0.563 rs2425111 chr20:34319765 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -10.68 -0.55 2.2e-22 Total cholesterol levels; CESC cis rs1348850 0.526 rs10803912 chr2:178407176 A/C cg23306229 chr2:178417860 TTC30B -0.78 -7.35 -0.41 2.52e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1691799 0.867 rs1495497 chr12:66770020 A/T cg16791601 chr12:66731901 HELB -0.75 -12.92 -0.62 5.97e-30 White blood cell count (basophil); CESC cis rs67311347 0.955 rs6782746 chr3:40510592 A/G cg24209194 chr3:40518798 ZNF619 -0.53 -6.88 -0.39 4.25e-11 Renal cell carcinoma; CESC cis rs1215050 0.791 rs7688192 chr4:98900798 G/T cg05340658 chr4:99064831 C4orf37 -0.53 -6.94 -0.39 2.96e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs910316 0.737 rs175048 chr14:75479894 A/T cg08847533 chr14:75593920 NEK9 -0.88 -15.45 -0.69 7.88e-39 Height; CESC cis rs6693567 0.565 rs1776273 chr1:150270209 C/T cg09579323 chr1:150459698 TARS2 0.42 5.56 0.32 6.46e-8 Migraine; CESC cis rs17433780 0.836 rs17434342 chr1:89505742 C/G cg09516651 chr1:89888402 LOC400759 -0.6 -9.04 -0.49 3.29e-17 Carotid intima media thickness; CESC cis rs72799341 1.000 rs72799341 chr16:30936743 G/A cg02466173 chr16:30829666 NA -0.41 -5.35 -0.31 1.86e-7 Diastolic blood pressure; CESC cis rs6570726 0.935 rs12663205 chr6:145818378 G/A cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs116095464 0.558 rs59284383 chr5:284525 C/G cg20965017 chr5:231967 SDHA -0.46 -5.2 -0.3 4.02e-7 Breast cancer; CESC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.97 9.29 0.5 5.68e-18 Platelet count; CESC cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg23283495 chr1:209979779 IRF6 -0.33 -5.37 -0.31 1.74e-7 Monobrow; CESC cis rs72772090 0.539 rs72773932 chr5:96118148 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.21 -0.3 3.74e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg20891283 chr12:69753455 YEATS4 0.91 15.06 0.68 1.86e-37 Blood protein levels; CESC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg10691866 chr7:65817282 TPST1 -0.33 -5.44 -0.32 1.21e-7 Aortic root size; CESC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg14196790 chr5:131705035 SLC22A5 0.37 5.77 0.33 2.19e-8 Blood metabolite levels; CESC cis rs9811920 0.683 rs793439 chr3:99637783 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 6.49 0.37 4.22e-10 Axial length; CESC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg06558623 chr16:89946397 TCF25 0.68 5.89 0.34 1.17e-8 Skin colour saturation; CESC cis rs11723261 0.582 rs61792238 chr4:112283 G/A cg12746427 chr4:53362 ZNF718;ZNF595 0.45 5.33 0.31 2.12e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs35146811 0.586 rs10267212 chr7:99595422 T/C cg14163444 chr7:99595348 NA -0.39 -5.11 -0.3 6.28e-7 Coronary artery disease; CESC cis rs2439831 0.681 rs484029 chr15:43619560 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.75 0.55 1.33e-22 Lung cancer in ever smokers; CESC cis rs8070128 0.601 rs8080602 chr17:17954728 G/C cg16928487 chr17:17741425 SREBF1 0.55 9.13 0.49 1.86e-17 Total body bone mineral density; CESC cis rs11098499 0.909 rs9759478 chr4:120367998 G/A cg09307838 chr4:120376055 NA 0.92 12.77 0.62 2.08e-29 Corneal astigmatism; CESC cis rs16854884 0.586 rs2011080 chr3:143756149 T/G cg06585982 chr3:143692056 C3orf58 0.49 6.63 0.38 1.89e-10 Economic and political preferences (feminism/equality); CESC cis rs2439831 0.850 rs10438303 chr15:44016417 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.76 0.38 8.96e-11 Lung cancer in ever smokers; CESC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg07701084 chr6:150067640 NUP43 0.48 6.69 0.38 1.35e-10 Lung cancer; CESC cis rs10465746 0.967 rs11576870 chr1:84333301 G/A cg10977910 chr1:84465055 TTLL7 0.48 6.52 0.37 3.64e-10 Obesity-related traits; CESC cis rs3820068 0.580 rs7512308 chr1:16006604 C/A cg18133145 chr1:16060689 PLEKHM2 -0.43 -5.32 -0.31 2.19e-7 Systolic blood pressure; CESC cis rs9616064 0.531 rs9616086 chr22:47050744 G/A cg25730555 chr22:47059586 GRAMD4 0.46 5.73 0.33 2.71e-8 Urate levels in obese individuals; CESC cis rs6964587 0.732 rs12539523 chr7:91710836 G/A cg01689657 chr7:91764605 CYP51A1 0.28 5.13 0.3 5.67e-7 Breast cancer; CESC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg02574844 chr11:5959923 NA -0.44 -6.54 -0.37 3.17e-10 DNA methylation (variation); CESC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg00129232 chr17:37814104 STARD3 0.56 7.41 0.41 1.72e-12 Glomerular filtration rate (creatinine); CESC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg11764359 chr7:65958608 NA -0.63 -8.13 -0.45 1.66e-14 Aortic root size; CESC cis rs2985684 1.000 rs2147712 chr14:50091684 G/A cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.48 -5.66 -0.33 3.83e-8 Carotid intima media thickness; CESC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg11644478 chr21:40555479 PSMG1 -0.81 -12.21 -0.6 1.68e-27 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11015833 chr12:83079681 TMTC2 -0.65 -7.92 -0.44 6.61e-14 Gut microbiome composition (summer); CESC cis rs6089584 0.526 rs6089619 chr20:60610916 C/T cg24733560 chr20:60626293 TAF4 0.45 6.75 0.38 9.16e-11 Body mass index; CESC cis rs2522056 1.000 rs2522054 chr5:131799526 G/T cg24060327 chr5:131705240 SLC22A5 0.6 6.66 0.38 1.61e-10 Lymphocyte counts;Fibrinogen; CESC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg15664640 chr17:80829946 TBCD -0.64 -9.4 -0.5 2.63e-18 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15563237 chr1:47799827 CMPK1 0.57 6.32 0.36 1.1e-9 Gut microbiome composition (summer); CESC cis rs863345 0.564 rs4614256 chr1:158464611 T/G cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs9911578 0.867 rs4793941 chr17:56472366 G/A cg05425664 chr17:57184151 TRIM37 0.45 6.32 0.36 1.09e-9 Intelligence (multi-trait analysis); CESC cis rs11718455 0.883 rs4682926 chr3:44006170 C/T cg08738300 chr3:44038990 NA 0.46 6.12 0.35 3.33e-9 Coronary artery disease; CESC cis rs9828933 0.766 rs704361 chr3:63883671 T/G cg16258503 chr3:63850278 ATXN7;THOC7 0.8 7.84 0.43 1.12e-13 Type 2 diabetes; CESC trans rs2693676 0.504 rs870827 chr14:99604585 A/G cg17465227 chr4:47427752 GABRB1 0.6 6.63 0.38 1.84e-10 Corneal curvature; CESC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs11190604 0.943 rs11190574 chr10:102234331 T/C cg07080220 chr10:102295463 HIF1AN 0.51 5.15 0.3 5.13e-7 Palmitoleic acid (16:1n-7) levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07934232 chr19:36619082 NA -0.43 -6.34 -0.36 9.6e-10 Gambling; CESC cis rs660498 0.507 rs34773871 chr10:27727645 G/A cg25705717 chr10:27608719 NA 0.49 5.75 0.33 2.45e-8 Asthma (childhood onset); CESC cis rs7697216 0.668 rs7666569 chr4:175840903 T/C cg14561282 chr4:175839468 ADAM29 0.49 5.6 0.33 5.35e-8 Breast cancer; CESC cis rs3008870 0.755 rs2815365 chr1:67499628 C/T cg02640540 chr1:67518911 SLC35D1 0.46 5.64 0.33 4.33e-8 Lymphocyte percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03227570 chr1:17766306 RCC2 -0.45 -6.25 -0.36 1.65e-9 Fibrinogen levels; CESC cis rs72781680 0.566 rs72796106 chr2:23901362 A/C cg08917208 chr2:24149416 ATAD2B 0.84 8.23 0.45 8.63e-15 Lymphocyte counts; CESC cis rs7312933 0.966 rs7977365 chr12:42513127 G/A cg01256987 chr12:42539512 GXYLT1 -0.34 -5.23 -0.31 3.46e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg22862634 chr11:62369728 EML3;MTA2 0.6 8.51 0.46 1.32e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg19318889 chr4:1322082 MAEA 0.56 6.79 0.39 7.23e-11 Longevity; CESC cis rs6582630 0.585 rs12422588 chr12:38478675 C/T cg26384229 chr12:38710491 ALG10B -0.41 -5.41 -0.32 1.42e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs6088580 0.524 rs6088567 chr20:33263872 A/T cg24642439 chr20:33292090 TP53INP2 -0.47 -5.48 -0.32 9.79e-8 Glomerular filtration rate (creatinine); CESC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg26839252 chr6:160211577 TCP1;MRPL18 0.44 5.03 0.3 9.06e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg15445000 chr17:37608096 MED1 0.39 6.15 0.35 2.85e-9 Glomerular filtration rate (creatinine); CESC cis rs9910055 0.659 rs8079310 chr17:42270291 A/G cg19774624 chr17:42201019 HDAC5 -0.88 -14.17 -0.66 2.58e-34 Total body bone mineral density; CESC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg27125505 chr17:43679177 LOC644172 -0.48 -6.74 -0.38 1.01e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs35955747 0.902 rs11703927 chr22:31644964 G/A cg25791279 chr22:32026902 PISD -0.5 -5.98 -0.35 7.04e-9 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs962856 1.000 rs6722203 chr2:67569193 G/A cg09028215 chr2:67624308 ETAA1 -0.43 -5.5 -0.32 8.95e-8 Pancreatic cancer; CESC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.68 6.7 0.38 1.25e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10461617 0.535 rs7709874 chr5:56047451 C/T cg24531977 chr5:56204891 C5orf35 -0.64 -8.16 -0.45 1.33e-14 Type 2 diabetes; CESC cis rs6963495 0.818 rs115609508 chr7:105163716 C/A cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs854765 0.822 rs1889014 chr17:17767165 C/T cg16928487 chr17:17741425 SREBF1 0.58 10.01 0.52 3.32e-20 Total body bone mineral density; CESC cis rs1152591 1.000 rs1152591 chr14:64680848 A/G cg23250157 chr14:64679961 SYNE2 0.56 8.2 0.45 1.04e-14 Atrial fibrillation; CESC cis rs2204008 0.623 rs1607878 chr12:38376000 A/G cg13010199 chr12:38710504 ALG10B 0.43 5.45 0.32 1.15e-7 Bladder cancer; CESC cis rs6785206 0.772 rs6439134 chr3:128323504 C/T cg16766828 chr3:128327626 NA -0.64 -6.53 -0.37 3.38e-10 Lymphocyte percentage of white cells; CESC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg13607699 chr17:42295918 UBTF -0.58 -7.57 -0.42 6.06e-13 Total body bone mineral density; CESC cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg04478727 chr12:58166393 METTL1;FAM119B 0.7 8.91 0.48 8.33e-17 Multiple sclerosis; CESC cis rs1185460 1.000 rs1799993 chr11:118958127 A/C cg23280166 chr11:118938394 VPS11 -0.45 -6.28 -0.36 1.35e-9 Coronary artery disease; CESC cis rs2806561 0.729 rs35919647 chr1:23326072 C/T cg12483005 chr1:23474871 LUZP1 -0.32 -5.06 -0.3 7.9e-7 Height; CESC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg00933542 chr6:150070202 PCMT1 0.3 5.11 0.3 6.15e-7 Lung cancer; CESC trans rs57221529 0.825 rs7443550 chr5:578404 G/T cg25482853 chr8:67687455 SGK3 1.01 10.17 0.53 9.74e-21 Lung disease severity in cystic fibrosis; CESC cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg26597838 chr10:835615 NA -0.84 -9.38 -0.5 3.01e-18 Eosinophil percentage of granulocytes; CESC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg26338869 chr17:61819248 STRADA 0.69 9.24 0.49 8.57e-18 Prudent dietary pattern; CESC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.62 0.33 4.92e-8 Bipolar disorder; CESC cis rs4642101 0.737 rs4299468 chr3:12825559 G/A cg05775895 chr3:12838266 CAND2 0.39 5.99 0.35 6.95e-9 QRS complex (12-leadsum); CESC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg26304593 chr6:42947056 PEX6 0.44 5.66 0.33 3.87e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs8062405 0.754 rs3859172 chr16:28566158 G/T cg07382826 chr16:28625726 SULT1A1 0.31 5.12 0.3 5.91e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg04282206 chr17:62833786 PLEKHM1P 0.57 6.57 0.37 2.6e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4953318 0.619 rs35744969 chr2:46353140 C/A cg12428440 chr2:46370979 PRKCE 0.44 5.75 0.33 2.52e-8 Red blood cell count;Hematocrit;Red blood cell traits; CESC cis rs1843834 0.721 rs6436507 chr2:225598242 T/A cg22455342 chr2:225449267 CUL3 0.41 5.24 0.31 3.2e-7 IgE levels in asthmatics (D.p. specific); CESC cis rs8031584 0.918 rs3817498 chr15:31268781 T/C cg14298792 chr15:30685198 CHRFAM7A -0.42 -5.09 -0.3 6.89e-7 Huntington's disease progression; CESC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg25036284 chr2:26402008 FAM59B 0.86 9.36 0.5 3.44e-18 Gut microbiome composition (summer); CESC cis rs2180341 0.574 rs13192350 chr6:127677762 G/T cg27446573 chr6:127587934 RNF146 0.6 8.18 0.45 1.18e-14 Breast cancer; CESC cis rs116095464 0.867 rs10074958 chr5:230828 C/T cg22496380 chr5:211416 CCDC127 -0.75 -8.7 -0.47 3.54e-16 Breast cancer; CESC cis rs61841072 0.922 rs2344124 chr1:243127644 A/G cg02356786 chr1:243265016 LOC731275 0.4 5.03 0.3 9.1e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03104356 chr8:30013879 DCTN6 0.58 6.35 0.36 9.43e-10 Gut microbiome composition (summer); CESC cis rs36051895 0.659 rs58345215 chr9:5043767 A/T cg02405213 chr9:5042618 JAK2 -0.49 -5.84 -0.34 1.55e-8 Pediatric autoimmune diseases; CESC cis rs854765 0.547 rs2955356 chr17:17964717 G/A cg09796270 chr17:17721594 SREBF1 -0.38 -5.12 -0.3 5.97e-7 Total body bone mineral density; CESC cis rs12477438 0.798 rs4324365 chr2:99623845 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg26818010 chr10:134567672 INPP5A -0.86 -10.61 -0.55 3.67e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.71 0.62 3.31e-29 Gut microbiome composition (summer); CESC cis rs9325144 0.534 rs1973293 chr12:38679575 C/T cg13010199 chr12:38710504 ALG10B 0.42 5.76 0.33 2.31e-8 Morning vs. evening chronotype; CESC cis rs2262909 0.849 rs2666447 chr19:22132868 T/A cg11619707 chr19:22235551 ZNF257 -0.32 -5.15 -0.3 5.02e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs4820539 1.000 rs916583 chr22:23469267 C/T cg14186256 chr22:23484241 RTDR1 0.81 14.45 0.66 2.68e-35 Bone mineral density; CESC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg03467027 chr4:99064603 C4orf37 0.49 6.24 0.36 1.75e-9 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08679808 chr17:79886116 LOC92659;MAFG -0.5 -7.06 -0.4 1.43e-11 Fibrinogen levels; CESC cis rs12369635 1.000 rs12369635 chr12:129561356 C/T cg01909103 chr12:129572610 TMEM132D -0.75 -6.44 -0.37 5.48e-10 Schizophrenia (inflammation and infection response interaction); CESC cis rs2569991 0.588 rs62240725 chr3:12929360 A/G cg22481960 chr3:13008800 IQSEC1 0.55 6.58 0.37 2.47e-10 Periodontitis (DPAL); CESC cis rs4919087 0.962 rs10882891 chr10:99059645 C/A cg25902810 chr10:99078978 FRAT1 0.74 10.75 0.55 1.34e-22 Monocyte count; CESC cis rs3793683 0.597 rs12767469 chr10:134587261 C/G cg18305652 chr10:134549665 INPP5A 0.48 6.85 0.39 5.07e-11 Migraine; CESC cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg17644776 chr2:200775616 C2orf69 0.56 6.81 0.39 6.4e-11 Osteoporosis; CESC cis rs2243480 1.000 rs464895 chr7:65527106 A/G cg18252515 chr7:66147081 NA -1.23 -12.45 -0.61 2.44e-28 Diabetic kidney disease; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg20553782 chr10:104403435 TRIM8 -0.51 -6.33 -0.36 1.04e-9 Gut microbiota (bacterial taxa); CESC cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12939298 chr14:75643618 TMED10 0.46 6.08 0.35 4.19e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg07216194 chr8:27182965 PTK2B -0.43 -6.25 -0.36 1.64e-9 Vertical cup-disc ratio; CESC cis rs1215050 0.791 rs155019 chr4:98759126 G/A cg05340658 chr4:99064831 C4orf37 0.51 6.65 0.38 1.63e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1559088 0.847 rs2287679 chr19:33600764 T/C cg17764715 chr19:33622953 WDR88 0.48 6.2 0.36 2.2e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2573652 0.755 rs6598286 chr15:100515985 G/T cg00587665 chr15:100533223 ADAMTS17 -0.39 -6.25 -0.36 1.61e-9 Height; CESC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg24642844 chr7:1081250 C7orf50 -0.58 -7.25 -0.41 4.71e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12681366 0.623 rs10106494 chr8:95483454 A/G cg13257157 chr8:95487014 RAD54B 0.47 5.68 0.33 3.47e-8 Nonsyndromic cleft lip with cleft palate; CESC cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg12386194 chr3:101231763 SENP7 0.58 6.19 0.36 2.33e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.694 rs202618 chr22:41822856 A/G cg03806693 chr22:41940476 POLR3H 1.2 14.5 0.67 1.86e-35 Vitiligo; CESC cis rs8033133 0.706 rs12594112 chr15:25350127 A/C cg14481604 chr15:25334117 SNORD116-22 -0.35 -5.43 -0.32 1.27e-7 Blood osmolality (transformed sodium); CESC cis rs7615952 1.000 rs9289275 chr3:125648659 A/T cg05084668 chr3:125655381 ALG1L -0.5 -5.86 -0.34 1.36e-8 Blood pressure (smoking interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11688874 chr10:28822482 WAC -0.41 -6.23 -0.36 1.83e-9 Gambling; CESC cis rs6570726 0.846 rs7762536 chr6:145923145 T/C cg23711669 chr6:146136114 FBXO30 0.85 12.48 0.61 2.03e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs9303401 0.659 rs62081315 chr17:56781468 T/C cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC cis rs4727963 0.869 rs2402634 chr7:122797119 C/T cg03640110 chr7:122635026 TAS2R16 0.33 5.11 0.3 6.14e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg26408565 chr15:76604113 ETFA -0.4 -5.93 -0.34 9.58e-9 Blood metabolite levels; CESC cis rs12477438 0.765 rs2278895 chr2:99613484 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs7197653 0.748 rs61460037 chr16:68336125 A/C cg26727032 chr16:67993705 SLC12A4 -0.53 -5.15 -0.3 4.98e-7 Magnesium levels; CESC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs34779708 0.750 rs35032841 chr10:35312687 G/A cg03585969 chr10:35415529 CREM 0.76 9.89 0.52 7.54e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs73206853 0.563 rs16940992 chr12:111207515 C/T cg04375036 chr12:111181819 PPP1CC 0.47 5.19 0.3 4.11e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7666738 0.830 rs34892904 chr4:98938097 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.536 rs1587381 chr15:76769620 G/A cg22467129 chr15:76604101 ETFA -0.38 -5.82 -0.34 1.69e-8 Blood metabolite levels; CESC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg22433210 chr17:43662623 NA -0.93 -10.71 -0.55 1.77e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19545348 chr1:211434133 RCOR3 0.51 6.83 0.39 5.68e-11 Gut microbiota (bacterial taxa); CESC cis rs9929218 0.551 rs1886697 chr16:68716179 T/C cg02972257 chr16:68554789 NA -0.42 -5.18 -0.3 4.34e-7 Colorectal cancer; CESC cis rs2228479 0.850 rs11639788 chr16:89807543 G/A cg19635926 chr16:89946313 TCF25 0.68 5.15 0.3 4.99e-7 Skin colour saturation; CESC cis rs763121 0.853 rs3747170 chr22:39067331 G/A cg14440974 chr22:39074834 NA -0.42 -5.81 -0.34 1.75e-8 Menopause (age at onset); CESC cis rs72781680 0.898 rs17509001 chr2:24021231 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs6594499 0.872 rs6594498 chr5:110458351 G/A cg04022379 chr5:110408740 TSLP 0.33 5.94 0.34 8.75e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs1691799 0.899 rs1168294 chr12:66733988 T/C cg16791601 chr12:66731901 HELB -0.75 -13.03 -0.62 2.51e-30 White blood cell count (basophil); CESC cis rs9896933 0.832 rs77512810 chr17:80804589 C/T cg19500275 chr17:80737654 TBCD 0.63 6.1 0.35 3.82e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs11167764 1.000 rs7730511 chr5:141480418 T/C cg08523384 chr5:141488047 NDFIP1 -0.38 -5.62 -0.33 4.87e-8 Crohn's disease; CESC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.94 8.59 0.47 7.33e-16 Platelet count; CESC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg17294928 chr15:75287854 SCAMP5 -0.47 -6.19 -0.36 2.26e-9 Breast cancer; CESC cis rs6912958 0.516 rs242278 chr6:88047059 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.71 10.75 0.55 1.35e-22 Monocyte percentage of white cells; CESC cis rs1729951 0.575 rs361245 chr3:136695706 A/G cg03617693 chr3:136751559 NA 0.38 5.34 0.31 2e-7 Neuroticism; CESC cis rs2243480 1.000 rs58669269 chr7:65951953 T/C cg12463550 chr7:65579703 CRCP 0.71 5.46 0.32 1.08e-7 Diabetic kidney disease; CESC cis rs11098499 0.866 rs72676074 chr4:120359841 A/C cg09307838 chr4:120376055 NA 0.97 14.07 0.65 5.69e-34 Corneal astigmatism; CESC cis rs2952156 0.920 rs2517953 chr17:37841211 G/C cg20243544 chr17:37824526 PNMT 0.63 8.1 0.45 1.99e-14 Asthma; CESC cis rs870825 0.616 rs1401360 chr4:185643571 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs9790314 0.747 rs1599386 chr3:160856314 C/T cg03342759 chr3:160939853 NMD3 0.41 5.19 0.3 4.11e-7 Morning vs. evening chronotype; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg18141532 chr1:104068301 RNPC3 0.5 6.68 0.38 1.38e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg18180107 chr4:99064573 C4orf37 -0.4 -5.3 -0.31 2.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1348850 0.634 rs1534304 chr2:178489264 C/T cg22681709 chr2:178499509 PDE11A -0.48 -6.49 -0.37 4.17e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg24110177 chr3:50126178 RBM5 -0.54 -7.55 -0.42 7.06e-13 Intelligence (multi-trait analysis); CESC cis rs727505 0.954 rs58618031 chr7:124583896 T/C cg23710748 chr7:124431027 NA -0.39 -6.27 -0.36 1.46e-9 Lewy body disease; CESC cis rs1044826 0.597 rs1017468 chr3:139145778 A/G cg00490450 chr3:139108681 COPB2 0.41 5.09 0.3 6.9e-7 Obesity-related traits; CESC cis rs6570726 0.846 rs6899900 chr6:145883873 T/G cg23711669 chr6:146136114 FBXO30 0.87 12.96 0.62 4.33e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2637266 1.000 rs1907319 chr10:78337049 A/G cg18941641 chr10:78392320 NA -0.37 -6.69 -0.38 1.34e-10 Pulmonary function; CESC cis rs9894429 0.683 rs112612275 chr17:79552604 C/A cg18240062 chr17:79603768 NPLOC4 -0.87 -12.62 -0.61 6.39e-29 Eye color traits; CESC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC trans rs931812 0.825 rs35515344 chr8:101896769 C/G cg20993868 chr7:22813445 NA 0.56 7.84 0.43 1.13e-13 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg22535103 chr8:58192502 C8orf71 -0.91 -9.94 -0.52 5.5e-20 Developmental language disorder (linguistic errors); CESC cis rs72634258 0.503 rs71637401 chr1:7837012 G/A cg26816564 chr1:7831052 VAMP3 0.67 6.0 0.35 6.63e-9 Inflammatory bowel disease; CESC cis rs568617 1.000 rs568617 chr11:65653242 C/T cg19792802 chr11:65647270 CTSW 0.36 5.44 0.32 1.24e-7 Crohn's disease; CESC cis rs7267979 0.808 rs84816 chr20:25459919 G/A cg08601574 chr20:25228251 PYGB 0.36 5.23 0.31 3.44e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg11644478 chr21:40555479 PSMG1 1.03 16.81 0.72 1.2e-43 Cognitive function; CESC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg02475777 chr4:1388615 CRIPAK 0.74 9.29 0.5 5.92e-18 Longevity; CESC cis rs10242455 0.702 rs3528 chr7:99055940 T/C cg13560068 chr7:99070416 ZNF789 0.67 5.14 0.3 5.4e-7 Blood metabolite levels; CESC cis rs6754311 0.509 rs10188066 chr2:136539513 G/A cg15123519 chr2:136567270 LCT 0.3 5.22 0.31 3.69e-7 Mosquito bite size; CESC cis rs4889855 0.505 rs8077626 chr17:78600552 G/C cg16591659 chr17:78472290 NA -0.33 -5.25 -0.31 3.08e-7 Fractional excretion of uric acid; CESC cis rs919433 0.963 rs4850429 chr2:198178409 A/G cg03934865 chr2:198174659 NA 0.41 5.66 0.33 4e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4822044 0.561 rs132781 chr22:42046122 T/G cg17376030 chr22:41985996 PMM1 -0.79 -8.79 -0.48 1.94e-16 Cannabis dependence symptom count; CESC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg04553112 chr3:125709451 NA -0.51 -5.58 -0.32 5.83e-8 Blood pressure (smoking interaction); CESC cis rs6570726 0.791 rs6902410 chr6:145905261 G/A cg23711669 chr6:146136114 FBXO30 0.97 14.56 0.67 1.09e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs1163251 0.837 rs517533 chr1:120229170 T/G cg19096424 chr1:120255104 PHGDH 0.5 6.22 0.36 1.95e-9 Blood metabolite levels; CESC cis rs5758659 0.679 rs134870 chr22:42652317 T/C cg00645731 chr22:42541494 CYP2D7P1 -0.31 -5.35 -0.31 1.9e-7 Cognitive function; CESC cis rs2354432 0.607 rs72692962 chr1:146802674 C/A cg25205988 chr1:146714368 CHD1L -1.03 -9.0 -0.48 4.56e-17 Mitochondrial DNA levels; CESC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.73 0.55 1.51e-22 Height; CESC cis rs9287719 0.781 rs6714413 chr2:10758859 C/T cg00105475 chr2:10696890 NA 0.35 5.07 0.3 7.65e-7 Prostate cancer; CESC cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg12386194 chr3:101231763 SENP7 0.45 5.61 0.33 5.02e-8 Colorectal cancer; CESC trans rs10074525 0.885 rs35299092 chr5:90276745 A/G cg22855255 chr17:50237267 CA10 -0.34 -6.01 -0.35 5.96e-9 Obesity-related traits; CESC cis rs7927592 0.913 rs7116994 chr11:68254627 C/T cg16797656 chr11:68205561 LRP5 0.4 5.68 0.33 3.52e-8 Total body bone mineral density; CESC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg04756594 chr16:24857601 SLC5A11 -0.45 -5.19 -0.3 4.09e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7264396 0.528 rs7273880 chr20:34551507 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.35 -0.54 2.7e-21 Total cholesterol levels; CESC cis rs7845219 0.525 rs6471501 chr8:95922491 A/G cg16049864 chr8:95962084 TP53INP1 -0.5 -7.41 -0.41 1.67e-12 Type 2 diabetes; CESC cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg10760299 chr15:45669010 GATM -0.38 -5.15 -0.3 5.09e-7 Homoarginine levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16779626 chr15:41709933 RTF1 0.5 6.29 0.36 1.32e-9 Gut microbiota (bacterial taxa); CESC cis rs13242816 1.000 rs55977427 chr7:116110768 C/T cg04696780 chr7:116139425 CAV2 -0.59 -5.28 -0.31 2.65e-7 P wave duration; CESC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.87 14.29 0.66 1e-34 Menarche (age at onset); CESC cis rs611744 0.647 rs2594358 chr8:109256018 A/G cg21045802 chr8:109455806 TTC35 0.52 6.64 0.38 1.77e-10 Dupuytren's disease; CESC cis rs8078723 0.668 rs4239225 chr17:38127112 G/A cg17467752 chr17:38218738 THRA 0.55 8.04 0.44 2.91e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs5753037 0.653 rs140123 chr22:30143206 A/G cg01021169 chr22:30184971 ASCC2 0.45 6.29 0.36 1.28e-9 Type 1 diabetes; CESC cis rs9399135 0.967 rs9399129 chr6:135285148 C/A cg24558204 chr6:135376177 HBS1L 0.5 6.64 0.38 1.73e-10 Red blood cell count; CESC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg24829409 chr8:58192753 C8orf71 -0.7 -9.37 -0.5 3.27e-18 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05317605 chr19:4558499 SEMA6B 0.54 6.82 0.39 6.06e-11 Gut microbiome composition (summer); CESC cis rs9527 0.614 rs4919691 chr10:104624475 A/C cg04362960 chr10:104952993 NT5C2 0.46 5.79 0.34 1.97e-8 Arsenic metabolism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27576415 chr15:41709087 RTF1 0.5 6.42 0.37 6.09e-10 Gut microbiota (bacterial taxa); CESC cis rs34779708 0.931 rs35997236 chr10:35376690 C/T cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs9649213 0.614 rs4729432 chr7:97947055 G/C cg09267113 chr7:98030324 BAIAP2L1 -0.44 -5.92 -0.34 1.01e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1564271 0.528 rs1980756 chr10:26979371 G/C cg13837822 chr10:26931731 LOC731789 0.43 6.59 0.38 2.37e-10 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CESC cis rs3741798 1.000 rs61922027 chr12:12486444 C/T cg08615371 chr12:12503544 MANSC1 0.87 6.35 0.36 9.19e-10 Cerebrospinal fluid biomarker levels; CESC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.68 -0.33 3.49e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7635838 0.718 rs2249051 chr3:11403234 G/A cg00170343 chr3:11313890 ATG7 0.5 7.05 0.4 1.57e-11 HDL cholesterol; CESC cis rs17384381 1.000 rs12758768 chr1:85835206 C/T cg16011679 chr1:85725395 C1orf52 0.81 8.16 0.45 1.33e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg13012494 chr21:47604986 C21orf56 -0.44 -5.9 -0.34 1.11e-8 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02994162 chr1:159915569 IGSF9 0.55 6.18 0.35 2.42e-9 Gut microbiome composition (summer); CESC cis rs6570726 0.935 rs454370 chr6:145846729 T/G cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 2e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg25204440 chr1:209979598 IRF6 0.65 6.71 0.38 1.21e-10 Cleft lip with or without cleft palate; CESC cis rs2204008 0.744 rs11495519 chr12:38060546 C/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg20243544 chr17:37824526 PNMT -0.51 -6.22 -0.36 1.89e-9 Glomerular filtration rate (creatinine); CESC cis rs4727027 0.834 rs7811446 chr7:148773226 G/T cg23158103 chr7:148848205 ZNF398 -0.41 -6.53 -0.37 3.38e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs250677 0.958 rs43147 chr5:148417103 C/G cg18129178 chr5:148520854 ABLIM3 0.48 5.5 0.32 9.07e-8 Breast cancer; CESC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg18230493 chr5:56204884 C5orf35 -0.62 -8.3 -0.45 5.39e-15 Initial pursuit acceleration; CESC cis rs9768139 0.733 rs13225172 chr7:158120334 G/A cg24154853 chr7:158122151 PTPRN2 0.43 6.53 0.37 3.36e-10 Calcium levels; CESC cis rs147649347 1 rs147649347 chr2:24210076 GATAA/G cg08917208 chr2:24149416 ATAD2B 1.01 9.08 0.49 2.55e-17 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs61931739 0.500 rs4436630 chr12:34394200 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.75 0.43 2.01e-13 Morning vs. evening chronotype; CESC cis rs6570726 0.837 rs419991 chr6:145864212 C/T cg23711669 chr6:146136114 FBXO30 0.8 11.78 0.59 4.84e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg26338869 chr17:61819248 STRADA 0.69 9.11 0.49 2.04e-17 Prudent dietary pattern; CESC cis rs2072732 0.861 rs4576609 chr1:2938265 C/T cg15211996 chr1:2936768 ACTRT2 0.35 5.75 0.33 2.47e-8 Plateletcrit; CESC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg08470875 chr2:26401718 FAM59B 0.66 6.44 0.37 5.58e-10 Gut microbiome composition (summer); CESC cis rs7129220 0.623 rs35815123 chr11:10119764 G/A cg01453529 chr11:10209919 SBF2 -0.48 -5.35 -0.31 1.86e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs62064224 0.748 rs72813015 chr17:30693331 T/C cg12855166 chr17:30846586 MYO1D 0.41 5.21 0.3 3.74e-7 Schizophrenia; CESC cis rs4595586 0.545 rs2197940 chr12:39401937 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs1595825 0.891 rs16825786 chr2:198794681 G/T cg10820045 chr2:198174542 NA 0.4 5.07 0.3 7.32e-7 Ulcerative colitis; CESC cis rs68170813 0.641 rs12534124 chr7:107119047 G/A cg02696742 chr7:106810147 HBP1 -0.56 -5.26 -0.31 3.03e-7 Coronary artery disease; CESC cis rs7335046 0.505 rs6491493 chr13:99900420 C/G cg21788972 chr13:99853209 UBAC2 -0.4 -5.07 -0.3 7.64e-7 Basal cell carcinoma; CESC cis rs698833 0.962 rs698829 chr2:44730846 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.33 0.31 2.09e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg19193384 chr17:30244184 NA -0.69 -6.44 -0.37 5.6e-10 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.05e-7 Colonoscopy-negative controls vs population controls; CESC trans rs17060993 0.618 rs17056484 chr8:26848328 C/T cg26814335 chr8:6584320 AGPAT5 -0.66 -6.29 -0.36 1.33e-9 Musician's dystonia; CESC cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg17366294 chr4:99064904 C4orf37 0.58 8.28 0.45 6.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2066819 1.000 rs17118403 chr12:56630067 C/T cg26714650 chr12:56694279 CS -1.42 -10.04 -0.53 2.52e-20 Psoriasis vulgaris; CESC cis rs28374715 0.681 rs7163989 chr15:41614621 A/G cg20272979 chr15:41787780 ITPKA 0.39 5.16 0.3 4.86e-7 Ulcerative colitis; CESC cis rs1707322 0.752 rs4660313 chr1:46110841 A/G cg03146154 chr1:46216737 IPP -0.8 -11.24 -0.57 3.12e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9660992 0.710 rs1768587 chr1:205236432 C/T cg00857998 chr1:205179979 DSTYK 0.47 5.35 0.31 1.87e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs1050631 0.556 rs4267398 chr18:33767749 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.52 6.59 0.38 2.35e-10 Esophageal squamous cell cancer (length of survival); CESC cis rs1964356 0.967 rs17701675 chr8:8850633 A/G cg15556689 chr8:8085844 FLJ10661 -0.43 -5.68 -0.33 3.58e-8 Mean corpuscular volume; CESC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg18904891 chr8:8559673 CLDN23 -0.42 -5.26 -0.31 3e-7 Mood instability; CESC cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg24308560 chr3:49941425 MST1R 0.61 8.83 0.48 1.46e-16 Intelligence (multi-trait analysis); CESC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg19622623 chr12:86230825 RASSF9 -0.47 -5.96 -0.34 7.92e-9 Major depressive disorder; CESC cis rs2635047 0.713 rs9304344 chr18:44758665 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.43 -5.75 -0.33 2.41e-8 Educational attainment; CESC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs889312 0.500 rs702688 chr5:56190986 A/G cg14703610 chr5:56206110 C5orf35 0.46 5.89 0.34 1.19e-8 Breast cancer;Breast cancer (early onset); CESC cis rs123509 0.687 rs17238972 chr3:42819975 C/G cg12982090 chr3:42733453 KBTBD5 -0.64 -7.27 -0.41 4.03e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs116095464 1.000 rs10475185 chr5:306981 C/T cg22496380 chr5:211416 CCDC127 -0.89 -5.62 -0.33 4.78e-8 Breast cancer; CESC cis rs10752881 0.839 rs6692207 chr1:183085304 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.49e-35 Colorectal cancer; CESC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg16325326 chr1:53192061 ZYG11B 0.71 11.36 0.57 1.26e-24 Monocyte count; CESC cis rs7216064 1.000 rs8067892 chr17:65837983 A/G cg07042672 chr17:66097459 LOC651250 -0.57 -6.69 -0.38 1.32e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6964587 1.000 rs10488512 chr7:91753579 C/T cg17063962 chr7:91808500 NA 0.58 7.95 0.44 5.44e-14 Breast cancer; CESC cis rs1707322 1.000 rs4298677 chr1:46306619 G/A cg06784218 chr1:46089804 CCDC17 0.32 5.49 0.32 9.45e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2425143 0.730 rs7263640 chr20:34314725 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.2 0.3 4.03e-7 Blood protein levels; CESC cis rs1729951 0.575 rs1682333 chr3:136688618 G/A cg25687071 chr3:136751404 NA 0.39 5.17 0.3 4.67e-7 Neuroticism; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10423227 chr2:64752200 AFTPH -0.44 -6.43 -0.37 5.76e-10 Gambling; CESC cis rs9303401 0.704 rs7359501 chr17:56641200 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.52 6.8 0.39 6.98e-11 Cognitive test performance; CESC cis rs2625529 0.617 rs6494973 chr15:72145728 A/T cg16672083 chr15:72433130 SENP8 0.38 5.58 0.32 5.89e-8 Red blood cell count; CESC cis rs7429990 0.965 rs1060407 chr3:47958037 G/T cg11946769 chr3:48343235 NME6 0.45 5.55 0.32 6.93e-8 Educational attainment (years of education); CESC cis rs7605827 0.930 rs11688071 chr2:15612626 T/G cg19274914 chr2:15703543 NA 0.33 5.96 0.34 8.22e-9 Educational attainment (years of education); CESC cis rs10791323 0.627 rs2723614 chr11:133705871 T/G cg06766960 chr11:133703094 NA -0.4 -5.69 -0.33 3.37e-8 Childhood ear infection; CESC cis rs7264396 0.563 rs2425116 chr20:34323553 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.88e-22 Total cholesterol levels; CESC cis rs854765 0.647 rs741782 chr17:18019712 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.47 0.46 1.74e-15 Total body bone mineral density; CESC cis rs3733585 0.725 rs6449201 chr4:9973894 C/T cg11266682 chr4:10021025 SLC2A9 -0.58 -10.87 -0.56 5.22e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs727563 0.636 rs2187795 chr22:42092225 C/A cg03806693 chr22:41940476 POLR3H 1.13 13.07 0.63 1.86e-30 Crohn's disease;Inflammatory bowel disease; CESC cis rs7562790 0.624 rs68111949 chr2:36655465 A/G cg09467607 chr2:36825704 FEZ2 0.32 5.14 0.3 5.26e-7 QRS duration;QRS complex (Cornell); CESC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.76 12.54 0.61 1.26e-28 Personality dimensions; CESC cis rs1670533 1.000 rs10003009 chr4:1050849 G/A cg04106633 chr4:1044584 NA 0.41 5.12 0.3 5.87e-7 Recombination rate (females); CESC cis rs1707322 1.000 rs10890377 chr1:46406594 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1707322 0.964 rs1707339 chr1:46513179 A/G cg05343316 chr1:45956843 TESK2 -0.44 -5.44 -0.32 1.2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6541297 0.703 rs611841 chr1:230309481 C/A cg20703242 chr1:230279135 GALNT2 -0.43 -5.59 -0.33 5.51e-8 Coronary artery disease; CESC cis rs11650494 0.908 rs74830554 chr17:47431950 G/A cg08112188 chr17:47440006 ZNF652 1.28 8.43 0.46 2.19e-15 Prostate cancer; CESC trans rs6499188 1.000 rs6499188 chr16:68674788 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.6 0.42 5.1e-13 Ulcerative colitis; CESC cis rs2415984 0.579 rs2642103 chr14:46963280 C/T cg14871534 chr14:47121158 RPL10L 0.35 5.32 0.31 2.21e-7 Number of children ever born; CESC cis rs10751667 0.600 rs7950955 chr11:1011490 G/A cg06064525 chr11:970664 AP2A2 -0.33 -5.63 -0.33 4.64e-8 Alzheimer's disease (late onset); CESC cis rs10411936 0.712 rs8100755 chr19:16593415 G/A cg10248733 chr19:16607483 C19orf44;CALR3 0.57 6.81 0.39 6.51e-11 White blood cell count;Multiple sclerosis; CESC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg14298792 chr15:30685198 CHRFAM7A -0.48 -5.66 -0.33 4.02e-8 Huntington's disease progression; CESC cis rs4481887 0.893 rs10736379 chr1:248455876 A/T cg00666640 chr1:248458726 OR2T12 0.37 6.1 0.35 3.72e-9 Common traits (Other); CESC cis rs17376456 0.877 rs10052428 chr5:93476530 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.33 0.31 2.11e-7 Diabetic retinopathy; CESC cis rs9611565 0.765 rs132905 chr22:41799106 C/A cg17376030 chr22:41985996 PMM1 -0.58 -6.19 -0.36 2.22e-9 Vitiligo; CESC cis rs11997175 0.740 rs6991071 chr8:33814103 G/A ch.8.33884649F chr8:33765107 NA 0.66 9.06 0.49 3.03e-17 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03003689 chr1:156674970 CRABP2 0.54 6.18 0.35 2.35e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg21724239 chr8:58056113 NA 0.58 5.98 0.34 7.26e-9 Developmental language disorder (linguistic errors); CESC cis rs2370759 1.000 rs7910776 chr10:32639093 C/T cg18270830 chr10:32634957 EPC1 0.73 6.71 0.38 1.2e-10 Sexual dysfunction (female); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16534196 chr19:56089807 ZNF579 0.5 6.68 0.38 1.39e-10 Fibrinogen levels; CESC cis rs854765 0.964 rs12950562 chr17:17995166 C/T cg04398451 chr17:18023971 MYO15A 0.67 9.39 0.5 2.97e-18 Total body bone mineral density; CESC cis rs10256972 0.527 rs28671326 chr7:1174973 G/A cg23978390 chr7:1156363 C7orf50 0.65 9.4 0.5 2.64e-18 Longevity;Endometriosis; CESC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg02428538 chr16:24856791 SLC5A11 -0.49 -5.2 -0.3 3.98e-7 Intelligence (multi-trait analysis); CESC cis rs11623869 0.772 rs12587310 chr14:103907286 G/A cg12935359 chr14:103987150 CKB 0.58 9.02 0.48 3.89e-17 Bone mineral density; CESC trans rs561341 0.714 rs474455 chr17:30312465 A/T cg27661571 chr11:113659931 NA -0.71 -7.4 -0.41 1.86e-12 Hip circumference adjusted for BMI; CESC cis rs6088765 0.606 rs2425024 chr20:33844938 G/T cg24642439 chr20:33292090 TP53INP2 -0.44 -5.42 -0.32 1.37e-7 Ulcerative colitis; CESC cis rs78456975 1.000 rs10208340 chr2:1563100 G/A cg26248373 chr2:1572462 NA -0.59 -5.66 -0.33 3.87e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9595066 0.941 rs9533777 chr13:44708720 C/T cg04068111 chr13:44716778 NA 0.46 6.82 0.39 6.26e-11 Schizophrenia; CESC cis rs9733 0.635 rs486836 chr1:150875967 A/T cg22823121 chr1:150693482 HORMAD1 -0.35 -5.11 -0.3 6.31e-7 Tonsillectomy; CESC cis rs1062177 1.000 rs2915882 chr5:151145436 T/C cg12924095 chr5:151150029 G3BP1 0.48 6.2 0.36 2.21e-9 Preschool internalizing problems; CESC cis rs7560272 0.538 rs17434655 chr2:73923089 C/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.91 -0.39 3.57e-11 Schizophrenia; CESC cis rs561341 0.505 rs28708703 chr17:30386845 C/G cg19193384 chr17:30244184 NA -0.52 -5.35 -0.31 1.88e-7 Hip circumference adjusted for BMI; CESC cis rs748404 0.560 rs1060939 chr15:43816917 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.15 0.4 8.33e-12 Lung cancer; CESC cis rs72781680 0.800 rs56398785 chr2:24091515 T/A cg08917208 chr2:24149416 ATAD2B 1.11 10.15 0.53 1.13e-20 Lymphocyte counts; CESC cis rs1775715 0.870 rs7912121 chr10:32228995 T/G cg04359828 chr10:32216031 ARHGAP12 0.37 5.11 0.3 6.2e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs28489187 0.643 rs2011825 chr1:85844671 T/C cg16011679 chr1:85725395 C1orf52 0.47 5.64 0.33 4.25e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.63 0.38 1.84e-10 Bipolar disorder; CESC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.79 -0.55 9.49e-23 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09926380 chr3:10052611 LOC401052 0.48 6.08 0.35 4.25e-9 Gut microbiome composition (summer); CESC cis rs425277 0.585 rs3128294 chr1:2065343 G/C cg16545954 chr1:2118288 C1orf86 -0.35 -6.51 -0.37 3.82e-10 Height; CESC cis rs539096 0.500 rs2527776 chr1:44345292 G/A cg23954153 chr1:44402353 ARTN -0.35 -5.49 -0.32 9.27e-8 Intelligence (multi-trait analysis); CESC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg19468946 chr17:37922297 IKZF3 0.39 5.07 0.3 7.46e-7 Glomerular filtration rate (creatinine); CESC cis rs61996546 0.622 rs34916314 chr15:26833559 A/G cg15066197 chr15:26874202 GABRB3 -0.35 -5.09 -0.3 6.95e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg13206674 chr6:150067644 NUP43 0.39 5.4 0.31 1.47e-7 Lung cancer; CESC cis rs698833 0.892 rs1085483 chr2:44616047 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 6.54 0.37 3.23e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg21017887 chr14:105400489 NA 0.41 6.8 0.39 7.06e-11 Rheumatoid arthritis; CESC cis rs11690935 0.688 rs7600835 chr2:172521827 C/T cg13550731 chr2:172543902 DYNC1I2 -0.54 -7.14 -0.4 8.9e-12 Schizophrenia; CESC cis rs66573146 0.808 rs73202120 chr4:7005588 A/G cg26116260 chr4:7069785 GRPEL1 -0.72 -5.52 -0.32 8.05e-8 Granulocyte percentage of myeloid white cells; CESC cis rs4889855 0.556 rs4506961 chr17:78543182 G/A cg16591659 chr17:78472290 NA 0.41 6.82 0.39 6.04e-11 Fractional excretion of uric acid; CESC cis rs854765 0.547 rs9912096 chr17:17896673 A/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.19 0.45 1.14e-14 Total body bone mineral density; CESC cis rs2730245 0.527 rs842707 chr7:158656012 C/T cg24397884 chr7:158709396 WDR60 0.83 8.47 0.46 1.71e-15 Height; CESC cis rs9875589 0.509 rs2731330 chr3:14111588 C/G cg19554555 chr3:13937349 NA -0.45 -5.84 -0.34 1.54e-8 Ovarian reserve; CESC cis rs9911578 1.000 rs4398153 chr17:56968181 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.22 -0.31 3.67e-7 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04904834 chr1:179851103 TOR1AIP1 0.51 6.45 0.37 5.41e-10 Gut microbiota (bacterial taxa); CESC cis rs1215050 0.740 rs11097580 chr4:98767255 C/A cg05340658 chr4:99064831 C4orf37 0.53 6.85 0.39 5.29e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9858542 0.953 rs7622302 chr3:49547561 T/C cg03060546 chr3:49711283 APEH -0.53 -6.04 -0.35 5.21e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs17854409 0.881 rs68066790 chr20:61487150 T/A cg07645718 chr20:61493192 TCFL5 0.79 5.44 0.32 1.22e-7 Obesity-related traits; CESC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg11859384 chr17:80120422 CCDC57 0.38 5.15 0.3 5.1e-7 Life satisfaction; CESC cis rs6938 0.618 rs12901190 chr15:75231452 T/C cg14664628 chr15:75095509 CSK -0.51 -6.6 -0.38 2.2e-10 Breast cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14595275 chr17:62075755 C17orf72 0.5 6.37 0.36 8.24e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg16606324 chr3:10149918 C3orf24 0.43 5.36 0.31 1.81e-7 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02976575 chr7:97835841 LMTK2 0.49 6.67 0.38 1.51e-10 Fibrinogen levels; CESC cis rs3026101 0.671 rs886361 chr17:5292762 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.77 0.33 2.16e-8 Body mass index; CESC trans rs4716602 0.596 rs10253193 chr7:156157801 C/T cg07175507 chr18:77160758 NFATC1 -0.46 -6.28 -0.36 1.42e-9 Anti-saccade response; CESC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg18765753 chr7:1198926 ZFAND2A -0.41 -5.15 -0.3 5.19e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9916302 0.706 rs4488484 chr17:37717377 A/T cg07936489 chr17:37558343 FBXL20 0.97 11.39 0.57 1.03e-24 Glomerular filtration rate (creatinine); CESC cis rs344364 0.511 rs1657134 chr16:1953127 A/G cg03013636 chr16:1946785 NA 0.47 6.41 0.37 6.45e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs6831352 0.734 rs3100630 chr4:100031715 T/A cg12011299 chr4:100065546 ADH4 0.57 6.88 0.39 4.34e-11 Alcohol dependence; CESC cis rs10779751 1.000 rs1010447 chr1:11269796 A/G cg08854313 chr1:11322531 MTOR 0.76 9.88 0.52 8.71e-20 Body mass index; CESC cis rs4588572 0.643 rs10474555 chr5:77799193 A/G cg11547950 chr5:77652471 NA 0.44 5.76 0.33 2.3e-8 Triglycerides; CESC cis rs1707322 0.717 rs3014245 chr1:46086913 C/T cg03146154 chr1:46216737 IPP -0.79 -10.83 -0.55 7.06e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11785693 0.862 rs62491191 chr8:4993460 G/A cg26367366 chr8:4980734 NA 0.85 8.09 0.44 2.18e-14 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs28830936 0.510 rs7175346 chr15:42100674 G/A cg17847044 chr15:42102381 MAPKBP1 -0.44 -7.69 -0.43 2.84e-13 Diastolic blood pressure; CESC cis rs2559856 0.967 rs2695290 chr12:102087844 A/G cg15068132 chr12:102092402 CHPT1 0.39 5.23 0.31 3.43e-7 Blood protein levels; CESC cis rs916888 0.821 rs199525 chr17:44847834 T/G cg01570182 chr17:44337453 NA 0.93 10.7 0.55 1.93e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg23758822 chr17:41437982 NA 1.01 15.35 0.69 1.71e-38 Menopause (age at onset); CESC cis rs8112211 1.000 rs73043010 chr19:38823202 T/G cg14299480 chr19:38876666 GGN -0.42 -5.64 -0.33 4.29e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06773604 chr16:18995157 TMC7 -0.55 -6.15 -0.35 2.92e-9 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00357593 chr19:14530417 DDX39 -0.46 -6.04 -0.35 5.15e-9 Ulcerative colitis; CESC cis rs9287719 0.578 rs10168852 chr2:10746323 C/A cg00105475 chr2:10696890 NA 0.38 5.11 0.3 6.03e-7 Prostate cancer; CESC cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg21248554 chr2:27665150 KRTCAP3 -0.37 -7.33 -0.41 2.81e-12 Total body bone mineral density; CESC cis rs11997175 0.549 rs4357253 chr8:33652458 G/A ch.8.33884649F chr8:33765107 NA 0.66 8.38 0.46 3.14e-15 Body mass index; CESC cis rs9611519 0.761 rs35445172 chr22:41660301 G/A cg03806693 chr22:41940476 POLR3H -0.57 -6.62 -0.38 2.01e-10 Neuroticism; CESC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg07677032 chr17:61819896 STRADA 0.43 5.44 0.32 1.21e-7 Height; CESC cis rs11167764 0.638 rs7729747 chr5:141478055 C/A cg08523384 chr5:141488047 NDFIP1 -0.37 -5.19 -0.3 4.28e-7 Crohn's disease; CESC cis rs3087591 0.919 rs2012581 chr17:29560800 A/G cg24425628 chr17:29625626 OMG;NF1 -0.44 -5.43 -0.32 1.24e-7 Hip circumference; CESC cis rs3008870 1.000 rs3008894 chr1:67377739 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.03 13.7 0.64 1.14e-32 Lymphocyte percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05323904 chr16:691677 FAM195A -0.43 -6.03 -0.35 5.61e-9 Gambling; CESC cis rs3096299 0.679 rs3102338 chr16:89442250 C/G cg02187348 chr16:89574699 SPG7 0.49 6.5 0.37 4.04e-10 Multiple myeloma (IgH translocation); CESC cis rs7044106 0.791 rs4837792 chr9:123483559 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.34 5.55 0.32 7.02e-8 Hip circumference adjusted for BMI; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10384294 chr12:57636980 NA -0.45 -6.34 -0.36 9.59e-10 Asthma; CESC trans rs1728785 1.000 rs1645981 chr16:68571648 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.44 0.42 1.41e-12 Ulcerative colitis; CESC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg05368731 chr17:41323189 NBR1 0.6 8.29 0.45 5.67e-15 Menopause (age at onset); CESC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg15556689 chr8:8085844 FLJ10661 -0.44 -5.61 -0.33 5.06e-8 Mood instability; CESC cis rs9300255 0.596 rs7304782 chr12:123719444 A/G cg00376283 chr12:123451042 ABCB9 -0.67 -8.93 -0.48 7.11e-17 Neutrophil percentage of white cells; CESC cis rs6674176 0.932 rs7412307 chr1:44433864 C/G cg13606994 chr1:44402422 ARTN 0.4 5.71 0.33 3.05e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2439831 0.867 rs28415933 chr15:43635800 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.84 12.56 0.61 1.02e-28 Lung cancer in ever smokers; CESC cis rs7513165 0.935 rs4951316 chr1:204161490 C/T cg23788856 chr1:204159729 KISS1 0.37 5.04 0.3 8.81e-7 Psychosis proneness (hypomanic personality scale);Psychosis proneness (hypomanic personality scale and perceptual aberration scale);Psychosis proneness (hypomanic personality scale and revised social anhedonia scale);Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale); CESC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg22903657 chr4:1355424 KIAA1530 -0.38 -5.18 -0.3 4.5e-7 Obesity-related traits; CESC cis rs11190604 1.000 rs11190607 chr10:102303614 C/T cg07080220 chr10:102295463 HIF1AN 0.66 6.04 0.35 5.08e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs7903847 0.596 rs11189203 chr10:99159096 C/A cg20016023 chr10:99160130 RRP12 -0.3 -5.22 -0.31 3.56e-7 Granulocyte percentage of myeloid white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10071186 chr14:71194292 NA -0.37 -6.1 -0.35 3.8e-9 Gambling; CESC cis rs778371 0.723 rs1078323 chr2:233681512 T/G cg08000102 chr2:233561755 GIGYF2 -0.78 -11.63 -0.58 1.61e-25 Schizophrenia; CESC cis rs13253111 0.624 rs7357359 chr8:28094835 T/C cg26534493 chr8:28060551 NA 0.48 7.52 0.42 8.73e-13 Childhood body mass index; CESC cis rs1152591 0.543 rs1152594 chr14:64675044 C/T cg23250157 chr14:64679961 SYNE2 -0.44 -6.34 -0.36 1.01e-9 Atrial fibrillation; CESC cis rs2439831 0.850 rs3816792 chr15:44116986 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.69 -7.62 -0.42 4.41e-13 Lung cancer in ever smokers; CESC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.94 0.52 5.31e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg27170947 chr2:26402098 FAM59B -0.57 -6.75 -0.38 9.52e-11 Gut microbiome composition (summer); CESC trans rs731565 1.000 rs731565 chr7:147406262 C/T cg13413955 chr9:842914 DMRT1 -0.55 -6.06 -0.35 4.71e-9 Diabetic kidney disease; CESC cis rs7580658 0.929 rs4662575 chr2:128022215 C/T cg10021288 chr2:128175891 PROC -0.41 -6.45 -0.37 5.16e-10 Protein C levels; CESC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg04414720 chr1:150670196 GOLPH3L -0.57 -7.52 -0.42 8.27e-13 Melanoma; CESC cis rs6982240 0.514 rs7002268 chr8:142277340 A/G cg27411547 chr8:142287226 NA -0.53 -7.26 -0.41 4.22e-12 Tonsillectomy; CESC cis rs1707322 0.717 rs3014249 chr1:46079493 A/G cg05343316 chr1:45956843 TESK2 -0.52 -6.44 -0.37 5.59e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs208520 0.874 rs208485 chr6:66925654 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -10.02 -0.52 3.11e-20 Exhaled nitric oxide output; CESC cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg12292205 chr6:26970375 C6orf41 -0.49 -5.44 -0.32 1.24e-7 Intelligence (multi-trait analysis); CESC cis rs6912958 0.702 rs6906769 chr6:88235949 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.51 -6.82 -0.39 6.1e-11 Monocyte percentage of white cells; CESC cis rs7560272 0.538 rs4241257 chr2:73938607 T/C cg20560298 chr2:73613845 ALMS1 0.4 5.38 0.31 1.62e-7 Schizophrenia; CESC cis rs4819052 0.788 rs13049700 chr21:46701909 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.79 10.4 0.54 1.76e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs72781680 0.950 rs72796402 chr2:24180104 A/G cg20701182 chr2:24300061 SF3B14 0.78 6.82 0.39 5.98e-11 Lymphocyte counts; CESC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 13.15 0.63 1e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3008870 0.727 rs2755270 chr1:67474503 C/T cg02640540 chr1:67518911 SLC35D1 0.45 5.43 0.32 1.25e-7 Lymphocyte percentage of white cells; CESC cis rs3096299 0.967 rs7205785 chr16:89458984 A/G cg00750074 chr16:89608354 SPG7 -0.37 -5.24 -0.31 3.22e-7 Multiple myeloma (IgH translocation); CESC cis rs12997796 0.556 rs13004867 chr2:86982504 C/G cg25203885 chr2:87302643 LOC285074 -0.63 -5.12 -0.3 6e-7 Schizophrenia; CESC cis rs57221529 0.766 rs28563961 chr5:554498 C/G cg16447950 chr5:562315 NA -0.75 -7.74 -0.43 2.06e-13 Lung disease severity in cystic fibrosis; CESC cis rs3820068 0.532 rs1547034 chr1:15919049 T/A cg17385448 chr1:15911702 AGMAT 0.44 7.37 0.41 2.12e-12 Systolic blood pressure; CESC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg10150615 chr22:24372951 LOC391322 -0.58 -7.91 -0.44 6.93e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12142240 0.698 rs72677600 chr1:46834449 G/A cg10495392 chr1:46806563 NSUN4 0.58 6.07 0.35 4.34e-9 Menopause (age at onset); CESC cis rs2243480 1.000 rs316331 chr7:65604622 A/G cg13147721 chr7:65941812 NA 0.93 8.9 0.48 9.27e-17 Diabetic kidney disease; CESC cis rs9400271 0.632 rs9384704 chr6:109587209 C/T cg01475377 chr6:109611718 NA -0.47 -7.47 -0.42 1.15e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs9929218 0.954 rs72785165 chr16:68755635 T/A cg02972257 chr16:68554789 NA 0.54 6.26 0.36 1.52e-9 Colorectal cancer; CESC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg06634786 chr22:41940651 POLR3H 0.71 7.03 0.4 1.75e-11 Vitiligo; CESC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg13770153 chr20:60521292 NA -0.46 -5.88 -0.34 1.25e-8 Body mass index; CESC cis rs9354352 0.967 rs9354351 chr6:66696271 G/A cg07460842 chr6:66804631 NA 0.66 9.67 0.51 3.82e-19 Initial pursuit acceleration in psychotic disorders; CESC cis rs1030877 0.521 rs2576747 chr2:105978676 A/T cg02079111 chr2:105885981 TGFBRAP1 0.46 6.72 0.38 1.11e-10 Obesity-related traits; CESC cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg12193833 chr17:30244370 NA -0.68 -6.3 -0.36 1.24e-9 Hip circumference adjusted for BMI; CESC cis rs9814567 0.806 rs6799543 chr3:134216139 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.99 -0.35 6.73e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13413755 chr9:94186957 NFIL3 -0.45 -6.03 -0.35 5.42e-9 Gut microbiota (bacterial taxa); CESC cis rs2952156 0.920 rs2247862 chr17:37829129 A/G cg20243544 chr17:37824526 PNMT 0.58 7.13 0.4 9.71e-12 Asthma; CESC cis rs78456975 1.000 rs13400784 chr2:1564473 T/A cg26248373 chr2:1572462 NA -0.54 -5.25 -0.31 3.13e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7210086 0.808 rs3935122 chr17:70641315 C/T cg04206342 chr17:70636940 NA -0.35 -6.4 -0.37 7.01e-10 Ulcerative colitis; CESC cis rs7474896 0.526 rs1208716 chr10:38089273 T/A cg25427524 chr10:38739819 LOC399744 -0.48 -5.16 -0.3 4.76e-7 Obesity (extreme); CESC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg00166722 chr3:10149974 C3orf24 0.52 6.38 0.36 7.91e-10 Alzheimer's disease; CESC cis rs1413885 0.516 rs3818449 chr1:65844963 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.5 6.43 0.37 5.97e-10 Anticoagulant levels; CESC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.52 0.32 8.19e-8 Bipolar disorder; CESC cis rs3096299 0.933 rs3114848 chr16:89452771 G/A cg08392591 chr16:89556376 ANKRD11 0.4 5.1 0.3 6.45e-7 Multiple myeloma (IgH translocation); CESC cis rs9837602 0.592 rs629120 chr3:99425767 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.41 -5.5 -0.32 8.72e-8 Breast cancer; CESC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg04025307 chr7:1156635 C7orf50 0.41 5.62 0.33 4.93e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1348850 0.651 rs1901824 chr2:178225466 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.69 9.83 0.52 1.2e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8058578 1.000 rs8051050 chr16:30687909 A/G cg02466173 chr16:30829666 NA -0.45 -7.25 -0.41 4.68e-12 Multiple myeloma; CESC cis rs9811920 0.609 rs809415 chr3:99582242 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.53 -6.44 -0.37 5.6e-10 Axial length; CESC cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg25019033 chr10:957182 NA -0.65 -6.53 -0.37 3.28e-10 Eosinophil percentage of granulocytes; CESC cis rs9443189 0.762 rs2748944 chr6:76436106 A/G cg01950844 chr6:76311363 SENP6 0.69 7.86 0.43 9.43e-14 Prostate cancer; CESC cis rs9457247 0.967 rs2757054 chr6:167380501 A/G cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.65e-7 Crohn's disease; CESC cis rs2991971 0.967 rs12743512 chr1:45954033 A/G cg15605315 chr1:45957053 TESK2 -0.47 -6.2 -0.36 2.12e-9 High light scatter reticulocyte count; CESC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.95 14.06 0.65 6.32e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg00945666 chr1:160990265 F11R -0.34 -5.45 -0.32 1.16e-7 Granulocyte percentage of myeloid white cells; CESC trans rs208520 1.000 rs12195505 chr6:66986279 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.34 0.5 4.23e-18 Exhaled nitric oxide output; CESC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.19 0.3 4.26e-7 Cognitive function; CESC cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg05340658 chr4:99064831 C4orf37 0.76 11.21 0.57 4.1e-24 Colonoscopy-negative controls vs population controls; CESC cis rs7193541 0.825 rs4411525 chr16:74595502 A/C cg01733217 chr16:74700730 RFWD3 0.89 13.44 0.64 9.36e-32 Multiple myeloma; CESC cis rs642803 0.613 rs489574 chr11:65542739 C/T cg08755490 chr11:65554678 OVOL1 0.44 5.7 0.33 3.23e-8 Urate levels; CESC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4849845 0.598 rs11690576 chr2:121019800 A/G cg24070213 chr2:121070622 NA -0.46 -6.84 -0.39 5.36e-11 Mean platelet volume; CESC cis rs9796 0.689 rs692195 chr15:41444894 G/C cg12426344 chr15:41135900 SPINT1 -0.25 -5.48 -0.32 1e-7 Menopause (age at onset); CESC cis rs4654899 0.758 rs3820326 chr1:21277141 G/A cg05370193 chr1:21551575 ECE1 0.37 5.62 0.33 4.75e-8 Superior frontal gyrus grey matter volume; CESC cis rs864537 0.676 rs1773561 chr1:167421951 C/T cg09179987 chr1:167433047 CD247 0.51 7.67 0.43 3.24e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs1009170 0.794 rs3088123 chr14:92628952 A/C cg10324096 chr14:92587714 CPSF2;NDUFB1 0.52 5.03 0.3 9.19e-7 Dialysis-related mortality; CESC cis rs6963495 0.818 rs73190189 chr7:105164452 G/A cg02135003 chr7:105160482 PUS7 -0.46 -5.54 -0.32 7.17e-8 Bipolar disorder (body mass index interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18509826 chr3:52017385 ACY1 0.51 6.77 0.38 8.23e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7937682 0.883 rs549143 chr11:111463779 C/T cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg00106254 chr7:1943704 MAD1L1 -0.48 -6.03 -0.35 5.49e-9 Bipolar disorder and schizophrenia; CESC cis rs2836633 0.929 rs4143428 chr21:40030582 G/T cg12884169 chr21:40033163 ERG 0.38 5.99 0.35 6.69e-9 Coronary artery disease; CESC cis rs9467711 0.538 rs35942482 chr6:26444938 T/A cg14345882 chr6:26364793 BTN3A2 0.63 5.85 0.34 1.42e-8 Autism spectrum disorder or schizophrenia; CESC cis rs6815814 0.898 rs73236646 chr4:38871385 T/C cg02016764 chr4:38805732 TLR1 -0.59 -6.68 -0.38 1.39e-10 Breast cancer; CESC cis rs2832191 0.720 rs2832194 chr21:30494250 T/C cg24692254 chr21:30365293 RNF160 -0.79 -12.11 -0.6 3.54e-27 Dental caries; CESC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg18404041 chr3:52824283 ITIH1 -0.4 -6.62 -0.38 1.98e-10 Bipolar disorder; CESC cis rs2425143 1.000 rs56904633 chr20:34400757 T/A cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.88 0.34 1.24e-8 Blood protein levels; CESC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg07701084 chr6:150067640 NUP43 0.43 5.84 0.34 1.56e-8 Lung cancer; CESC cis rs909674 0.690 rs5750823 chr22:39829973 C/T cg24399712 chr22:39784796 NA -0.76 -10.43 -0.54 1.46e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg16144293 chr14:75469539 EIF2B2 0.4 5.17 0.3 4.71e-7 Height; CESC cis rs2797160 1.000 rs9491471 chr6:125991715 C/T cg05901451 chr6:126070800 HEY2 -0.45 -6.58 -0.37 2.52e-10 Endometrial cancer; CESC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.83 0.39 5.76e-11 Bipolar disorder; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg15070096 chr1:156470876 MEF2D 0.49 6.25 0.36 1.68e-9 Psoriatic arthritis; CESC cis rs8067545 0.611 rs10491107 chr17:20188174 C/T cg13482628 chr17:19912719 NA 0.45 6.14 0.35 2.94e-9 Schizophrenia; CESC cis rs67478160 0.529 rs12880413 chr14:104267407 A/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.79 0.55 9.69e-23 Schizophrenia; CESC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg22963979 chr7:1858916 MAD1L1 -0.38 -5.19 -0.3 4.18e-7 Bipolar disorder and schizophrenia; CESC cis rs78456975 1.000 rs11884854 chr2:1566154 A/G cg26248373 chr2:1572462 NA -0.51 -5.16 -0.3 4.92e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs10927875 0.632 rs6677321 chr1:16149301 A/C cg21385522 chr1:16154831 NA -1.02 -16.41 -0.71 2.97e-42 Dilated cardiomyopathy; CESC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg17724175 chr1:150552817 MCL1 0.33 5.09 0.3 6.88e-7 Melanoma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05876094 chr1:174968893 CACYBP -0.4 -6.02 -0.35 5.8e-9 Gambling; CESC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg13770153 chr20:60521292 NA 0.76 11.17 0.57 5.53e-24 Obesity-related traits; CESC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg22800045 chr5:56110881 MAP3K1 0.69 8.16 0.45 1.36e-14 Initial pursuit acceleration; CESC trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg15556689 chr8:8085844 FLJ10661 0.51 6.47 0.37 4.69e-10 Retinal vascular caliber; CESC cis rs17125944 0.656 rs74825460 chr14:53390015 C/T cg00686598 chr14:53173677 PSMC6 0.91 6.17 0.35 2.5e-9 Alzheimer's disease (late onset); CESC cis rs1348850 0.567 rs2222711 chr2:178534110 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.37 0.41 2.24e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7914558 0.966 rs7085598 chr10:104650128 T/C cg08650961 chr10:104748594 CNNM2 0.33 5.37 0.31 1.75e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg15977278 chr12:104234975 NT5DC3 0.51 6.69 0.38 1.3100000000000001e-10 Tetralogy of Fallot; CESC trans rs11088226 0.645 rs7281844 chr21:33932435 T/C cg09050820 chr6:167586206 TCP10L2 0.88 8.47 0.46 1.72e-15 Gastritis; CESC cis rs477692 1.000 rs477692 chr10:131426022 T/C cg05714579 chr10:131428358 MGMT 0.53 7.22 0.41 5.66e-12 Response to temozolomide; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11464464 chr5:68513891 MRPS36 -0.67 -7.2 -0.4 6.3e-12 Gut microbiome composition (summer); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg10229899 chr1:49364797 AGBL4 0.45 6.13 0.35 3.18e-9 Recombination measurement; CESC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg11890956 chr21:40555474 PSMG1 -0.97 -16.62 -0.71 5.65e-43 Cognitive function; CESC cis rs2997447 0.706 rs55657303 chr1:26421012 A/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.67 5.55 0.32 6.83e-8 QRS complex (12-leadsum); CESC cis rs796364 1.000 rs281783 chr2:200751582 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.9 8.79 0.48 1.87e-16 Schizophrenia; CESC cis rs13082711 0.911 rs34307140 chr3:27467875 A/C cg02860705 chr3:27208620 NA 0.53 6.8 0.39 7.04e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs3733585 0.699 rs6852441 chr4:9973744 C/T cg11266682 chr4:10021025 SLC2A9 -0.58 -10.87 -0.56 5.22e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3820068 0.608 rs58140482 chr1:16043979 A/G cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.64e-7 Systolic blood pressure; CESC cis rs1832871 0.672 rs9457343 chr6:158740567 A/G cg07165851 chr6:158734300 TULP4 0.59 6.41 0.37 6.63e-10 Height; CESC cis rs9457247 1.000 rs389956 chr6:167407254 T/G cg07741184 chr6:167504864 NA 0.29 5.31 0.31 2.32e-7 Crohn's disease; CESC cis rs9916302 0.904 rs6503519 chr17:37706578 A/G cg15445000 chr17:37608096 MED1 0.4 6.5 0.37 3.95e-10 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18905668 chr11:18388147 GTF2H1 -0.55 -6.75 -0.38 9.41e-11 Gut microbiome composition (summer); CESC cis rs4969178 0.965 rs16971107 chr17:76394042 C/T cg05887092 chr17:76393375 PGS1 0.56 8.87 0.48 1.1e-16 HDL cholesterol levels; CESC cis rs4947534 1 rs4947534 chr7:56079094 T/C cg09872392 chr7:56161020 PHKG1 -0.42 -6.07 -0.35 4.49e-9 Amino acid levels;Blood metabolite levels; CESC cis rs9863 0.828 rs12303671 chr12:124492610 T/G cg17562584 chr12:124393655 DNAH10 0.31 5.39 0.31 1.58e-7 White blood cell count; CESC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg22903471 chr2:27725779 GCKR -0.5 -7.17 -0.4 7.52e-12 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02603784 chr3:52294457 WDR82 -0.58 -7.22 -0.41 5.58e-12 Gut microbiome composition (summer); CESC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -5.18 -0.3 4.41e-7 Developmental language disorder (linguistic errors); CESC cis rs67311347 1.000 rs1004655 chr3:40490009 G/A cg24209194 chr3:40518798 ZNF619 0.51 6.16 0.35 2.74e-9 Renal cell carcinoma; CESC cis rs6121246 0.567 rs6058203 chr20:30198979 C/T cg13852791 chr20:30311386 BCL2L1 0.55 5.13 0.3 5.66e-7 Mean corpuscular hemoglobin; CESC cis rs55728055 0.661 rs62237775 chr22:31965401 A/G cg01338084 chr22:32026380 PISD 1.15 8.06 0.44 2.64e-14 Age-related hearing impairment; CESC cis rs7089973 0.628 rs11196953 chr10:116607707 A/G cg25233709 chr10:116636983 FAM160B1 0.38 6.08 0.35 4.13e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2243480 1.000 rs709607 chr7:65449541 C/G cg18252515 chr7:66147081 NA 0.93 8.62 0.47 6.08e-16 Diabetic kidney disease; CESC cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg18850127 chr7:39170497 POU6F2 0.35 5.08 0.3 7.19e-7 IgG glycosylation; CESC cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg16339924 chr4:17578868 LAP3 0.63 8.09 0.45 2.13e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg18230493 chr5:56204884 C5orf35 -0.71 -8.72 -0.47 3.23e-16 Initial pursuit acceleration; CESC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg19592336 chr6:28129416 ZNF389 0.6 8.08 0.44 2.36e-14 Depression; CESC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg03806693 chr22:41940476 POLR3H -1.18 -14.76 -0.67 2.13e-36 Vitiligo; CESC cis rs9796 0.689 rs561301 chr15:41444723 C/T cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.21 -0.36 2.03e-9 Menopause (age at onset); CESC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg16325326 chr1:53192061 ZYG11B -0.69 -10.97 -0.56 2.48e-23 Monocyte count; CESC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 10.97 0.56 2.56e-23 Platelet count; CESC cis rs6121246 0.697 rs6088856 chr20:30226543 C/G cg13852791 chr20:30311386 BCL2L1 0.71 7.29 0.41 3.62e-12 Mean corpuscular hemoglobin; CESC cis rs722599 0.715 rs12147629 chr14:75307588 A/G cg11812906 chr14:75593930 NEK9 -0.46 -5.54 -0.32 7.17e-8 IgG glycosylation; CESC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs644799 0.623 rs17207890 chr11:95490754 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.61 7.58 0.42 5.7e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2204008 0.627 rs10878488 chr12:38148666 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.58 0.55 4.66e-22 Bladder cancer; CESC cis rs7208859 0.623 rs75136574 chr17:28934549 C/A cg19761014 chr17:28927070 LRRC37B2 0.82 6.21 0.36 2.01e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg00121533 chr1:75199117 CRYZ;TYW3 0.49 6.75 0.38 9.48e-11 Resistin levels; CESC cis rs12711979 0.765 rs7559345 chr2:3818523 G/A cg17052675 chr2:3827356 NA -0.42 -6.45 -0.37 5.34e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg05340658 chr4:99064831 C4orf37 0.78 11.94 0.59 1.39e-26 Colonoscopy-negative controls vs population controls; CESC cis rs870825 0.616 rs28636679 chr4:185627481 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs2276314 1.000 rs1540042 chr18:33555236 C/T cg05985134 chr18:33552581 C18orf21 0.64 7.58 0.42 5.71e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs10411262 0.935 rs2871987 chr19:47175528 A/G cg13467550 chr19:47212573 PRKD2 0.33 5.38 0.31 1.66e-7 Tonsillectomy; CESC trans rs1994135 0.617 rs10844642 chr12:33730368 A/C cg26384229 chr12:38710491 ALG10B 0.47 6.35 0.36 9.33e-10 Resting heart rate; CESC cis rs4820539 0.902 rs4822359 chr22:23474972 A/G cg14186256 chr22:23484241 RTDR1 0.82 14.46 0.66 2.45e-35 Bone mineral density; CESC cis rs72781680 1.000 rs72796329 chr2:24141912 G/A cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs763121 0.853 rs2072795 chr22:39064209 A/G cg14440974 chr22:39074834 NA 0.43 5.92 0.34 9.84e-9 Menopause (age at onset); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg25940728 chr20:48429179 SLC9A8 -0.5 -6.28 -0.36 1.37e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg19046167 chr17:80928561 B3GNTL1 0.45 5.33 0.31 2.1e-7 Glycated hemoglobin levels; CESC cis rs6736093 0.933 rs4848238 chr2:112754720 A/C cg12686935 chr2:112915763 FBLN7 -0.43 -5.65 -0.33 4.18e-8 Coronary artery disease; CESC cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg08564027 chr20:61660810 NA 0.9 15.37 0.69 1.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs17854409 1.000 rs6011427 chr20:61496680 C/T cg05147244 chr20:61493195 TCFL5 0.87 6.24 0.36 1.76e-9 Obesity-related traits; CESC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.11 -0.4 1.06e-11 Total body bone mineral density; CESC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg14703610 chr5:56206110 C5orf35 0.41 5.2 0.3 3.95e-7 Coronary artery disease; CESC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg27125505 chr17:43679177 LOC644172 0.49 6.53 0.37 3.43e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg18230493 chr5:56204884 C5orf35 -0.75 -8.9 -0.48 9.02e-17 Initial pursuit acceleration; CESC cis rs738322 0.935 rs4384 chr22:38572440 G/C cg17652424 chr22:38574118 PLA2G6 -0.33 -5.86 -0.34 1.35e-8 Cutaneous nevi; CESC cis rs3106136 0.527 rs10016806 chr4:95158495 G/T cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.59 -0.58 2.09e-25 Capecitabine sensitivity; CESC cis rs4899554 0.640 rs72719935 chr14:75724345 C/T cg18117039 chr14:75741733 NA 0.44 5.79 0.34 1.95e-8 Inflammatory bowel disease; CESC cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.78 8.21 0.45 9.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10089 0.953 rs1432614 chr5:127416919 A/G cg19767477 chr5:127420684 SLC12A2 -0.39 -5.06 -0.3 7.71e-7 Ileal carcinoids; CESC cis rs1799949 0.965 rs1842147 chr17:41435192 C/T cg05368731 chr17:41323189 NBR1 0.75 10.1 0.53 1.66e-20 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02182185 chr11:47600575 NDUFS3;KBTBD4 -0.48 -6.64 -0.38 1.72e-10 Fibrinogen levels; CESC cis rs10791097 0.694 rs7107595 chr11:130758556 C/T cg12179176 chr11:130786555 SNX19 0.65 10.05 0.53 2.46e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs80130819 0.591 rs17122651 chr12:48496660 C/T cg05342945 chr12:48394962 COL2A1 0.51 5.92 0.34 9.78e-9 Prostate cancer; CESC cis rs2425143 1.000 rs7264414 chr20:34446826 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.62 0.33 4.72e-8 Blood protein levels; CESC cis rs921968 0.509 rs7571743 chr2:219352572 C/T cg02176678 chr2:219576539 TTLL4 0.5 8.96 0.48 5.83e-17 Mean corpuscular hemoglobin concentration; CESC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg18765753 chr7:1198926 ZFAND2A -0.46 -6.75 -0.38 9.04e-11 Longevity;Endometriosis; CESC cis rs959260 0.688 rs9302989 chr17:73359270 G/A cg20590849 chr17:73267439 MIF4GD -0.56 -6.17 -0.35 2.61e-9 Systemic lupus erythematosus; CESC cis rs7680126 0.500 rs4697935 chr4:10149593 C/T cg00071950 chr4:10020882 SLC2A9 -0.6 -6.6 -0.38 2.26e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.77 10.87 0.56 5.23e-23 Prudent dietary pattern; CESC cis rs6540556 0.954 rs10863786 chr1:209937764 A/G cg05527609 chr1:210001259 C1orf107 -0.52 -6.49 -0.37 4.21e-10 Red blood cell count; CESC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg22903471 chr2:27725779 GCKR -0.56 -7.88 -0.44 8.25e-14 Total body bone mineral density; CESC cis rs9399137 0.507 rs12663810 chr6:135289782 G/C cg22676075 chr6:135203613 NA 0.55 7.25 0.41 4.69e-12 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg18876405 chr7:65276391 NA -0.54 -7.57 -0.42 6.06e-13 Aortic root size; CESC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.52 7.86 0.43 9.89e-14 Bipolar disorder; CESC cis rs2439831 0.867 rs4075674 chr15:43650230 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.46 0.54 1.12e-21 Lung cancer in ever smokers; CESC cis rs2204008 0.747 rs11514040 chr12:38201040 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC trans rs9467711 0.606 rs9379871 chr6:26375854 C/G cg06606381 chr12:133084897 FBRSL1 -0.74 -6.44 -0.37 5.71e-10 Autism spectrum disorder or schizophrenia; CESC cis rs208520 0.661 rs1776361 chr6:66822270 G/A cg07460842 chr6:66804631 NA -1.0 -13.52 -0.64 5.1e-32 Exhaled nitric oxide output; CESC cis rs7786808 0.741 rs62479982 chr7:158227546 A/G cg01191920 chr7:158217561 PTPRN2 -0.45 -7.99 -0.44 4.29e-14 Obesity-related traits; CESC cis rs11190604 1.000 rs10883508 chr10:102294413 G/A cg07080220 chr10:102295463 HIF1AN 0.68 6.43 0.37 5.89e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg18876405 chr7:65276391 NA 0.54 7.18 0.4 6.97e-12 Aortic root size; CESC cis rs752092 0.855 rs7171515 chr15:101769618 C/T cg19997662 chr15:101784653 CHSY1 -0.41 -5.48 -0.32 9.66e-8 Corneal structure; CESC cis rs798766 1.000 rs1665362 chr4:1726367 T/A cg10756475 chr4:1757242 NA 0.46 6.26 0.36 1.57e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs1633360 1 rs1633360 chr12:58108052 C/T cg04478727 chr12:58166393 METTL1;FAM119B -0.42 -5.51 -0.32 8.55e-8 Rheumatoid arthritis; CESC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4654899 0.714 rs12401630 chr1:21495049 G/A cg05370193 chr1:21551575 ECE1 0.46 7.14 0.4 8.89e-12 Superior frontal gyrus grey matter volume; CESC trans rs7945705 0.875 rs2653616 chr11:8885892 A/G cg10637292 chr12:52960529 KRT74 0.36 6.19 0.36 2.27e-9 Hemoglobin concentration; CESC cis rs11696845 0.649 rs6031782 chr20:43383832 A/G cg25301532 chr20:43378953 KCNK15 -0.33 -5.33 -0.31 2.15e-7 Obesity-related traits; CESC cis rs4722166 0.695 rs35779989 chr7:22800314 A/C cg13104385 chr7:22767384 IL6 0.39 5.67 0.33 3.78e-8 Lung cancer; CESC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg15813570 chr14:64854563 MTHFD1 -0.48 -6.57 -0.37 2.6e-10 Height; CESC cis rs9818758 0.607 rs55873331 chr3:49597055 C/T cg00383909 chr3:49044727 WDR6 0.82 5.13 0.3 5.59e-7 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs72781680 0.898 rs72786286 chr2:24074659 T/A cg20701182 chr2:24300061 SF3B14 0.62 5.6 0.33 5.24e-8 Lymphocyte counts; CESC cis rs72945132 0.882 rs947812 chr11:70209169 C/T cg14191688 chr11:70257035 CTTN 0.43 5.22 0.31 3.62e-7 Coronary artery disease; CESC cis rs7267979 1.000 rs4815418 chr20:25382211 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.39e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs12220238 1.000 rs10824130 chr10:76008931 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.68 0.33 3.61e-8 Soluble interleukin-2 receptor subunit alpha; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24869748 chr6:86303744 SNX14 0.55 6.26 0.36 1.51e-9 Gut microbiome composition (summer); CESC cis rs61931739 0.517 rs7958755 chr12:34294699 T/C cg19457237 chr12:34500585 NA -0.38 -5.19 -0.3 4.19e-7 Morning vs. evening chronotype; CESC cis rs6582630 0.502 rs1607867 chr12:38385463 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.23 0.36 1.87e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg12373951 chr3:133503437 NA 0.43 6.39 0.37 7.3e-10 Iron status biomarkers; CESC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg11644478 chr21:40555479 PSMG1 -0.57 -7.9 -0.44 7.71e-14 Menarche (age at onset); CESC cis rs9916302 0.561 rs12453198 chr17:37741879 T/C cg20243544 chr17:37824526 PNMT 0.56 5.14 0.3 5.26e-7 Glomerular filtration rate (creatinine); CESC cis rs4662945 0.603 rs2406981 chr2:130305487 A/G cg05962382 chr2:130345044 NA -0.48 -6.85 -0.39 5.15e-11 Response to cytidine analogues (gemcitabine); CESC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07898632 chr15:73345666 NEO1 0.65 7.21 0.4 5.75e-12 Gut microbiome composition (summer); CESC cis rs35995292 0.534 rs2008199 chr7:38939678 T/C cg19327137 chr7:38886074 VPS41 0.66 10.91 0.56 3.88e-23 Subjective well-being (multi-trait analysis); CESC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg18876405 chr7:65276391 NA 0.5 6.68 0.38 1.43e-10 Aortic root size; CESC cis rs3796352 1.000 rs34979715 chr3:53048960 G/A cg12962167 chr3:53033115 SFMBT1 0.67 5.32 0.31 2.17e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg13607699 chr17:42295918 UBTF 0.58 7.66 0.43 3.44e-13 Total body bone mineral density; CESC cis rs748404 0.660 rs2602141 chr15:43724646 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.25 0.45 7.39e-15 Lung cancer; CESC cis rs7000551 0.642 rs2449328 chr8:22375043 A/G cg12081754 chr8:22256438 SLC39A14 0.42 5.56 0.32 6.44e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs7927771 0.524 rs3816605 chr11:47857253 T/C cg20307385 chr11:47447363 PSMC3 0.62 8.68 0.47 4.02e-16 Subjective well-being; CESC cis rs9916302 0.904 rs11654018 chr17:37703740 C/T cg00129232 chr17:37814104 STARD3 0.57 7.44 0.42 1.39e-12 Glomerular filtration rate (creatinine); CESC cis rs2070488 0.775 rs6599211 chr3:38558830 A/G cg24069376 chr3:38537580 EXOG -0.34 -5.89 -0.34 1.18e-8 Electrocardiographic conduction measures; CESC cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg23711669 chr6:146136114 FBXO30 -0.99 -15.26 -0.68 3.83e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs7607369 0.536 rs13033409 chr2:219666509 T/G cg02176678 chr2:219576539 TTLL4 -0.36 -6.35 -0.36 9.45e-10 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs9911578 0.803 rs8069033 chr17:57131581 T/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -5.19 -0.3 4.23e-7 Intelligence (multi-trait analysis); CESC trans rs10511652 1.000 rs10511652 chr9:18362865 A/G cg02146966 chr17:18967117 NA 0.42 6.04 0.35 5.14e-9 Myopia; CESC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg21724239 chr8:58056113 NA 0.57 5.76 0.33 2.29e-8 Developmental language disorder (linguistic errors); CESC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg03806693 chr22:41940476 POLR3H -1.2 -15.25 -0.68 4.12e-38 Vitiligo; CESC cis rs11098499 1.000 rs12506395 chr4:120185094 C/T cg09307838 chr4:120376055 NA 0.88 11.63 0.58 1.52e-25 Corneal astigmatism; CESC cis rs9309473 1.000 rs10496193 chr2:73773503 G/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.51 -0.37 3.74e-10 Metabolite levels; CESC cis rs9611565 0.592 rs28750375 chr22:41990644 A/C cg06481639 chr22:41940642 POLR3H -0.57 -6.4 -0.37 7.18e-10 Vitiligo; CESC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg04772025 chr11:68637568 NA -0.52 -6.14 -0.35 3.06e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3820068 0.581 rs3940061 chr1:15941276 C/T cg13390004 chr1:15929781 NA 0.37 5.96 0.34 8.08e-9 Systolic blood pressure; CESC cis rs12682352 0.602 rs6993494 chr8:8667444 C/T cg06636001 chr8:8085503 FLJ10661 0.43 5.32 0.31 2.17e-7 Neuroticism; CESC cis rs644799 1.000 rs568668 chr11:95528209 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.94 0.48 6.65e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2991971 0.810 rs12738318 chr1:45929589 A/G cg05343316 chr1:45956843 TESK2 0.56 7.94 0.44 5.63e-14 High light scatter reticulocyte count; CESC cis rs7590368 0.673 rs2306922 chr2:10942520 C/T cg15705551 chr2:10952987 PDIA6 0.54 5.23 0.31 3.48e-7 Educational attainment (years of education); CESC cis rs3026101 0.671 rs739766 chr17:5290599 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.69 0.33 3.32e-8 Body mass index; CESC cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg11764359 chr7:65958608 NA 0.78 8.89 0.48 9.36e-17 Aortic root size; CESC cis rs2153904 0.793 rs12564209 chr1:205720212 C/G cg23034840 chr1:205782522 SLC41A1 -0.62 -5.97 -0.34 7.48e-9 Prostate-specific antigen levels; CESC trans rs1814175 0.817 rs4881627 chr11:49953955 C/A cg03929089 chr4:120376271 NA -0.93 -15.75 -0.7 6.66e-40 Height; CESC cis rs7408868 0.908 rs62113794 chr19:15277337 C/A cg14696996 chr19:15285081 NOTCH3 1.11 11.3 0.57 2.05e-24 Pulse pressure; CESC cis rs17401966 0.931 rs3737155 chr1:10459779 G/A cg15208524 chr1:10270712 KIF1B 0.41 5.12 0.3 5.94e-7 Hepatocellular carcinoma; CESC cis rs12155623 0.592 rs12682003 chr8:49865454 G/T cg00325661 chr8:49890786 NA 0.41 5.67 0.33 3.69e-8 Sudden cardiac arrest; CESC trans rs561341 1.000 rs15654 chr17:30326360 A/C cg27661571 chr11:113659931 NA -0.82 -7.63 -0.42 4.18e-13 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09417937 chr11:1298918 TOLLIP -0.51 -6.1 -0.35 3.81e-9 Gut microbiome composition (summer); CESC cis rs4237845 0.551 rs116263297 chr12:58273445 A/C cg04478727 chr12:58166393 METTL1;FAM119B 0.52 5.77 0.33 2.18e-8 Intelligence (multi-trait analysis); CESC cis rs6570726 0.526 rs9403699 chr6:145730685 G/T cg23711669 chr6:146136114 FBXO30 0.59 7.62 0.42 4.61e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg02896835 chr1:92012615 NA -0.51 -6.63 -0.38 1.84e-10 Breast cancer; CESC cis rs763121 0.853 rs5757204 chr22:39046700 A/C cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC cis rs10949834 0.878 rs2855727 chr7:73517852 T/G cg07137043 chr7:73588983 EIF4H -0.66 -5.7 -0.33 3.2e-8 Verbal memory performance (residualized delayed recall change); CESC cis rs1348850 0.526 rs2293475 chr2:178407897 C/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.61 -5.54 -0.32 7.18e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7666738 0.753 rs13137152 chr4:98938044 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.34 0.46 4.08e-15 Colonoscopy-negative controls vs population controls; CESC cis rs634534 0.561 rs613924 chr11:65769295 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.47 6.31 0.36 1.14e-9 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg18446336 chr7:2847575 GNA12 -0.34 -5.4 -0.31 1.49e-7 Height; CESC cis rs11098499 0.909 rs9994810 chr4:120381590 A/G cg24375607 chr4:120327624 NA 0.44 5.51 0.32 8.65e-8 Corneal astigmatism; CESC cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 8.83 0.48 1.43e-16 Hip circumference adjusted for BMI; CESC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg17971929 chr21:40555470 PSMG1 -0.87 -12.58 -0.61 8.68e-29 Cognitive function; CESC cis rs34779708 0.966 rs1478463 chr10:35473035 G/A cg04310649 chr10:35416472 CREM -0.54 -6.78 -0.38 7.74e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.27 -0.31 2.82e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs9811920 0.625 rs7631174 chr3:99913902 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 5.38 0.31 1.61e-7 Axial length; CESC cis rs7680126 0.596 rs10939835 chr4:10313750 A/G cg11266682 chr4:10021025 SLC2A9 -0.43 -5.29 -0.31 2.54e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs10206020 0.921 rs6605278 chr2:1547230 C/T cg26248373 chr2:1572462 NA -0.58 -6.59 -0.38 2.38e-10 IgG glycosylation; CESC cis rs9815354 0.904 rs73081347 chr3:41903582 T/C cg03022575 chr3:42003672 ULK4 0.7 6.18 0.36 2.38e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg22535103 chr8:58192502 C8orf71 -0.93 -12.03 -0.59 6.97e-27 Developmental language disorder (linguistic errors); CESC cis rs5013026 1 rs5013026 chr22:18171650 C/T cg19898043 chr22:18121309 BCL2L13 -0.42 -5.32 -0.31 2.17e-7 Neutrophil count; CESC cis rs1670533 1.000 rs2014318 chr4:1068778 C/T cg27284194 chr4:1044797 NA -0.44 -5.59 -0.32 5.56e-8 Recombination rate (females); CESC cis rs7089973 0.624 rs10885614 chr10:116609098 C/T cg25233709 chr10:116636983 FAM160B1 0.38 6.08 0.35 4.13e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9916302 0.652 rs9903269 chr17:37742383 A/T cg20243544 chr17:37824526 PNMT 0.56 5.14 0.3 5.26e-7 Glomerular filtration rate (creatinine); CESC cis rs9486715 0.867 rs9373833 chr6:96904998 A/G cg18709589 chr6:96969512 KIAA0776 -0.49 -6.91 -0.39 3.7e-11 Headache; CESC cis rs597539 0.654 rs7107137 chr11:68623712 A/G cg18350739 chr11:68623251 NA -0.46 -6.64 -0.38 1.73e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs9457247 1.000 rs1819333 chr6:167373547 G/T cg23791538 chr6:167370224 RNASET2 -0.59 -8.39 -0.46 3.02e-15 Crohn's disease; CESC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs2286503 1.000 rs2286503 chr7:22856606 C/T cg13679077 chr7:22862647 TOMM7 0.39 5.03 0.3 9.17e-7 Fibrinogen; CESC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg00166722 chr3:10149974 C3orf24 0.5 6.31 0.36 1.19e-9 Alzheimer's disease; CESC cis rs9329289 0.550 rs11251294 chr10:2562328 C/T cg05625103 chr10:2543513 NA -0.45 -6.1 -0.35 3.71e-9 Age-related hearing impairment; CESC trans rs35110281 0.755 rs4819270 chr21:45020919 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 6.99 0.39 2.2e-11 Mean corpuscular volume; CESC cis rs858239 0.932 rs1624451 chr7:23262435 A/T cg23682824 chr7:23144976 KLHL7 -0.44 -5.86 -0.34 1.37e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7666738 0.830 rs13136930 chr4:98937933 A/T cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs936229 0.813 rs2168519 chr15:75080872 T/C cg14664628 chr15:75095509 CSK -0.9 -13.32 -0.63 2.53e-31 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs6598955 0.502 rs6683157 chr1:26545865 G/A cg04990556 chr1:26633338 UBXN11 0.81 9.2 0.49 1.08e-17 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17749735 chr1:155051360 EFNA3 0.58 6.45 0.37 5.22e-10 Gut microbiome composition (summer); CESC cis rs4974559 0.501 rs1250093 chr4:1240911 G/A cg02980000 chr4:1222292 CTBP1 -0.75 -7.67 -0.43 3.18e-13 Systolic blood pressure; CESC cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg23649088 chr2:200775458 C2orf69 0.54 5.13 0.3 5.74e-7 Schizophrenia; CESC cis rs6693567 0.565 rs12731296 chr1:150411787 A/G cg09579323 chr1:150459698 TARS2 0.48 6.0 0.35 6.34e-9 Migraine; CESC trans rs116095464 0.558 rs57335027 chr5:262907 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.38e-11 Breast cancer; CESC cis rs11048434 0.736 rs11048344 chr12:9122609 G/C cg23795048 chr12:9217529 LOC144571 0.33 5.03 0.3 9.05e-7 Sjögren's syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23625236 chr1:214776790 CENPF 0.61 7.09 0.4 1.21e-11 Gut microbiome composition (summer); CESC cis rs2120019 1.000 rs7168680 chr15:75369212 G/A cg17294928 chr15:75287854 SCAMP5 -0.59 -6.61 -0.38 2.16e-10 Blood trace element (Zn levels); CESC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg07090678 chr1:91966139 CDC7 0.41 5.6 0.33 5.37e-8 Breast cancer; CESC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg08888203 chr3:10149979 C3orf24 0.52 6.65 0.38 1.63e-10 Alzheimer's disease; CESC cis rs7267979 0.966 rs2261747 chr20:25261784 G/A cg08601574 chr20:25228251 PYGB 0.39 5.61 0.33 5e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2282802 0.660 rs4463213 chr5:139545748 G/A cg26211634 chr5:139558579 C5orf32 -0.46 -6.63 -0.38 1.88e-10 Intelligence (multi-trait analysis); CESC cis rs6772849 1.000 rs9839508 chr3:128310794 A/T cg16766828 chr3:128327626 NA 0.32 5.17 0.3 4.7e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs2933343 0.729 rs1683780 chr3:128640239 C/T cg25356066 chr3:128598488 ACAD9 0.65 8.91 0.48 8.67e-17 IgG glycosylation; CESC cis rs9916302 0.904 rs8079303 chr17:37530755 G/C cg00129232 chr17:37814104 STARD3 0.57 7.44 0.42 1.38e-12 Glomerular filtration rate (creatinine); CESC trans rs9354308 0.901 rs2814096 chr6:66566131 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 7.98 0.44 4.55e-14 Metabolite levels; CESC cis rs911555 0.755 rs10148970 chr14:103892000 G/A cg12935359 chr14:103987150 CKB -0.56 -8.03 -0.44 3.16e-14 Intelligence (multi-trait analysis); CESC cis rs6426558 0.537 rs7523167 chr1:227365304 G/A cg10327440 chr1:227177885 CDC42BPA -0.46 -5.7 -0.33 3.19e-8 Neutrophil percentage of white cells; CESC cis rs6546550 0.901 rs6741449 chr2:70156589 A/G cg02498382 chr2:70120550 SNRNP27 -0.41 -7.13 -0.4 9.44e-12 Prevalent atrial fibrillation; CESC cis rs662064 0.962 rs620405 chr1:10554794 T/C cg20482658 chr1:10539492 PEX14 -0.37 -7.43 -0.42 1.51e-12 Asthma; CESC cis rs854765 0.583 rs8078138 chr17:17811251 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.52 7.22 0.41 5.44e-12 Total body bone mineral density; CESC cis rs6087990 0.871 rs4911252 chr20:31330115 A/G cg13636640 chr20:31349939 DNMT3B -0.83 -14.66 -0.67 4.77e-36 Ulcerative colitis; CESC cis rs8180040 0.966 rs9683033 chr3:47489820 C/T cg27129171 chr3:47204927 SETD2 0.62 9.25 0.49 7.87e-18 Colorectal cancer; CESC cis rs8180040 0.966 rs11711824 chr3:47468261 C/T cg27129171 chr3:47204927 SETD2 0.63 9.46 0.5 1.81e-18 Colorectal cancer; CESC cis rs2635047 0.638 rs2668758 chr18:44685679 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.32 5.03 0.3 9.22e-7 Educational attainment; CESC cis rs501120 1.000 rs605445 chr10:44756779 C/T cg09554077 chr10:44749378 NA 0.52 6.91 0.39 3.59e-11 Coronary artery disease;Coronary heart disease; CESC cis rs7267979 0.966 rs6050532 chr20:25308793 A/T cg08601574 chr20:25228251 PYGB -0.39 -5.61 -0.33 4.99e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs3747547 0.892 rs17516973 chr9:37968915 C/T cg13774184 chr9:37916125 SHB -0.72 -6.13 -0.35 3.15e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs11105298 0.891 rs11105314 chr12:89924559 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.5 -5.24 -0.31 3.25e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg00255919 chr5:131827918 IRF1 -0.56 -9.46 -0.5 1.72e-18 Asthma (sex interaction); CESC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 8.82 0.48 1.51e-16 Platelet count; CESC cis rs7267979 0.966 rs2261747 chr20:25261784 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 16.87 0.72 7.12e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs1904096 0.506 rs6532476 chr4:95192461 C/A cg11021082 chr4:95130006 SMARCAD1 -0.68 -11.15 -0.57 6.32e-24 Type 2 diabetes; CESC cis rs73206853 0.686 rs7974047 chr12:111119631 C/T cg12870014 chr12:110450643 ANKRD13A 0.64 5.21 0.3 3.87e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs11098499 0.738 rs72918577 chr4:120326701 G/A cg24375607 chr4:120327624 NA 0.47 5.91 0.34 1.03e-8 Corneal astigmatism; CESC trans rs561341 0.609 rs7209493 chr17:30197323 A/G cg20587970 chr11:113659929 NA 0.56 6.75 0.38 9.08e-11 Hip circumference adjusted for BMI; CESC cis rs17095355 1.000 rs9630102 chr10:111738662 A/T cg00817464 chr10:111662876 XPNPEP1 -0.44 -5.2 -0.3 3.98e-7 Biliary atresia; CESC cis rs2455799 0.613 rs2654654 chr3:15789242 C/T cg16303742 chr3:15540471 COLQ -0.39 -6.14 -0.35 3.01e-9 Mean platelet volume; CESC cis rs3741151 0.686 rs11828904 chr11:73139116 T/C cg17517138 chr11:73019481 ARHGEF17 0.62 5.31 0.31 2.31e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg04369109 chr6:150039330 LATS1 -0.39 -5.4 -0.32 1.45e-7 Lung cancer; CESC cis rs921968 0.565 rs7594046 chr2:219624170 A/G cg02176678 chr2:219576539 TTLL4 0.41 7.12 0.4 1e-11 Mean corpuscular hemoglobin concentration; CESC cis rs796364 1.000 rs281762 chr2:200799201 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.9 9.29 0.5 5.66e-18 Schizophrenia; CESC cis rs6460942 1.000 rs7791634 chr7:12401482 A/T cg20607287 chr7:12443886 VWDE -0.68 -7.81 -0.43 1.33e-13 Coronary artery disease; CESC cis rs7949030 0.588 rs2509982 chr11:62312318 C/T cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.42 -0.32 1.37e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg02297831 chr4:17616191 MED28 0.52 6.02 0.35 5.93e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10446143 chr21:44394730 PKNOX1 -0.45 -6.55 -0.37 2.95e-10 Gambling; CESC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg11843238 chr5:131593191 PDLIM4 0.37 5.39 0.31 1.53e-7 Breast cancer; CESC cis rs7258465 0.931 rs271626 chr19:18627067 C/T cg11102782 chr19:18549136 ISYNA1 0.37 5.13 0.3 5.54e-7 Breast cancer; CESC cis rs7843479 0.544 rs11135735 chr8:21791557 C/T cg17168535 chr8:21777572 XPO7 0.71 11.57 0.58 2.48e-25 Mean corpuscular volume; CESC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg18876405 chr7:65276391 NA 0.53 7.28 0.41 3.9e-12 Aortic root size; CESC cis rs4654899 1.000 rs72865329 chr1:21517567 G/A cg05370193 chr1:21551575 ECE1 0.41 6.27 0.36 1.44e-9 Superior frontal gyrus grey matter volume; CESC cis rs4835473 0.800 rs1849122 chr4:144899852 A/G cg25736465 chr4:144833511 NA 0.39 5.99 0.35 6.88e-9 Immature fraction of reticulocytes; CESC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.84 8.97 0.48 5.64e-17 Platelet count; CESC cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg19077165 chr18:44547161 KATNAL2 -0.51 -7.44 -0.42 1.4e-12 Personality dimensions; CESC cis rs477895 0.568 rs12418035 chr11:63871558 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 9.57 0.51 7.96e-19 Mean platelet volume; CESC cis rs116095464 0.867 rs10074958 chr5:230828 C/T cg22857025 chr5:266934 NA -1.29 -18.71 -0.75 2.22e-50 Breast cancer; CESC trans rs931812 0.757 rs34988706 chr8:101907062 C/T cg20993868 chr7:22813445 NA 0.42 6.33 0.36 1.04e-9 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs1153858 0.621 rs1706824 chr15:45579948 C/T cg21132104 chr15:45694354 SPATA5L1 0.75 8.97 0.48 5.5e-17 Homoarginine levels; CESC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg04013166 chr16:89971882 TCF25 0.69 7.12 0.4 1.04e-11 Skin colour saturation; CESC cis rs9303401 0.580 rs12946396 chr17:57164195 T/A cg25039879 chr17:56429692 SUPT4H1 0.5 5.13 0.3 5.66e-7 Cognitive test performance; CESC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19230575 chr3:179041494 ZNF639 0.58 6.96 0.39 2.71e-11 Gut microbiome composition (summer); CESC cis rs796364 0.951 rs769952 chr2:200734368 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.89 8.76 0.47 2.4e-16 Schizophrenia; CESC cis rs76878669 0.538 rs1546358 chr11:66175261 G/C cg18002602 chr11:66138449 SLC29A2 0.37 5.94 0.34 8.8e-9 Educational attainment (years of education); CESC cis rs2290159 0.800 rs9817675 chr3:12676113 C/T cg23032965 chr3:12705835 RAF1 0.53 5.67 0.33 3.76e-8 Cholesterol, total; CESC cis rs2777491 0.874 rs7161772 chr15:41611066 A/T cg18705301 chr15:41695430 NDUFAF1 -0.6 -8.98 -0.48 5.23e-17 Ulcerative colitis; CESC cis rs9911578 0.935 rs7216698 chr17:57007495 G/A cg05425664 chr17:57184151 TRIM37 -0.4 -5.47 -0.32 1.05e-7 Intelligence (multi-trait analysis); CESC cis rs10089 1.000 rs1842006 chr5:127508687 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.07 0.53 2.04e-20 Ileal carcinoids; CESC cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.583 rs9912895 chr17:17826020 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.55 -7.74 -0.43 2.04e-13 Total body bone mineral density; CESC cis rs10870270 0.913 rs115236491 chr10:133766855 T/G cg17892150 chr10:133769511 PPP2R2D -0.87 -12.67 -0.61 4.28e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs11792861 0.619 rs2289481 chr9:111712924 G/C cg05043794 chr9:111880884 C9orf5 -0.31 -5.64 -0.33 4.4e-8 Menarche (age at onset); CESC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg18904891 chr8:8559673 CLDN23 0.71 8.39 0.46 2.99e-15 Obesity-related traits; CESC cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.49 -8.37 -0.46 3.39e-15 Monocyte percentage of white cells; CESC cis rs9399137 0.507 rs28384513 chr6:135376209 T/G cg24558204 chr6:135376177 HBS1L 0.69 9.54 0.51 9.81e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7116495 0.609 rs7115513 chr11:71664495 T/A cg10381502 chr11:71823885 C11orf51 -1.09 -7.58 -0.42 5.83e-13 Severe influenza A (H1N1) infection; CESC cis rs9796 0.558 rs8043253 chr15:41503730 C/T cg20272979 chr15:41787780 ITPKA 0.34 5.05 0.3 8.32e-7 Menopause (age at onset); CESC cis rs4268898 0.662 rs2288074 chr2:24413595 C/T cg08917208 chr2:24149416 ATAD2B 0.62 5.79 0.34 1.95e-8 Asthma; CESC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.82 -0.52 1.29e-19 Developmental language disorder (linguistic errors); CESC cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg14829155 chr15:31115871 NA -0.7 -9.23 -0.49 9.02e-18 Huntington's disease progression; CESC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.81 0.34 1.77e-8 Tonsillectomy; CESC cis rs57244997 1.000 rs57244997 chr6:162397506 G/A cg17173639 chr6:162384350 PARK2 -0.82 -8.02 -0.44 3.46e-14 Mosquito bite size; CESC cis rs7130144 0.609 rs7928982 chr11:130432459 A/G cg26307797 chr11:130446613 NA -0.69 -6.6 -0.38 2.19e-10 Urate levels in lean individuals; CESC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg26343298 chr8:95960752 TP53INP1 0.36 5.95 0.34 8.55e-9 Type 2 diabetes; CESC cis rs10848704 0.956 rs10848703 chr12:2882250 C/T cg19995117 chr12:2880862 NA 0.56 9.06 0.49 3.01e-17 Quantitative traits; CESC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg11644478 chr21:40555479 PSMG1 1.03 16.91 0.72 5.38e-44 Cognitive function; CESC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 8.51 0.46 1.27e-15 Platelet count; CESC cis rs75477785 0.590 rs2282740 chr1:209900307 C/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.85 5.21 0.3 3.82e-7 Cleft lip with or without cleft palate; CESC cis rs7656342 0.622 rs2102872 chr4:9831358 T/C cg00071950 chr4:10020882 SLC2A9 0.4 5.41 0.32 1.4e-7 Gut microbiota (bacterial taxa); CESC cis rs6546537 0.550 rs6546531 chr2:69779963 C/A cg10773587 chr2:69614142 GFPT1 -0.43 -5.49 -0.32 9.29e-8 Serum thyroid-stimulating hormone levels; CESC cis rs2115630 0.967 rs8028490 chr15:85277888 G/A cg12501888 chr15:85177176 SCAND2 -0.39 -5.07 -0.3 7.37e-7 P wave terminal force; CESC cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg10556349 chr10:835070 NA 0.76 6.39 0.37 7.22e-10 Eosinophil percentage of granulocytes; CESC cis rs13040088 1.000 rs10854167 chr20:61533039 G/C cg23096297 chr20:61557774 DIDO1 0.97 10.76 0.55 1.19e-22 Menopause (age at onset); CESC cis rs6484504 0.532 rs2150212 chr11:31255935 G/A cg14844989 chr11:31128820 NA -0.41 -5.79 -0.34 1.96e-8 Red blood cell count; CESC cis rs7095944 0.584 rs10901814 chr10:126431281 G/C cg08799069 chr10:126477246 METTL10 -0.38 -5.34 -0.31 2.02e-7 Asthma; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg12869820 chr12:125478231 BRI3BP -0.42 -6.23 -0.36 1.86e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs61931739 0.534 rs10844828 chr12:34303109 C/T cg19457237 chr12:34500585 NA -0.37 -5.23 -0.31 3.45e-7 Morning vs. evening chronotype; CESC cis rs7165102 1.000 rs7178584 chr15:65795200 T/G cg11441148 chr15:65824328 PTPLAD1 -0.32 -5.32 -0.31 2.2e-7 Mean corpuscular hemoglobin; CESC cis rs208520 1.000 rs12193077 chr6:66989548 C/T cg07460842 chr6:66804631 NA 0.89 10.18 0.53 9.11e-21 Exhaled nitric oxide output; CESC cis rs6500395 0.962 rs989070 chr16:48602243 G/A cg04672837 chr16:48644449 N4BP1 0.47 5.8 0.34 1.9e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs79057730 0.528 rs6965219 chr7:821807 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.68 6.26 0.36 1.5e-9 Initial pursuit acceleration; CESC cis rs4563143 0.514 rs73029076 chr19:29292032 G/T cg04546413 chr19:29218101 NA 0.49 6.08 0.35 4.2e-9 Methadone dose in opioid dependence; CESC cis rs1729951 0.575 rs1654923 chr3:136692620 A/T cg03617693 chr3:136751559 NA 0.39 5.38 0.31 1.68e-7 Neuroticism; CESC cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg14416269 chr4:6271139 WFS1 0.48 8.17 0.45 1.25e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs875971 0.964 rs55748098 chr7:65763618 T/C cg26939375 chr7:64535504 NA -0.46 -6.07 -0.35 4.31e-9 Aortic root size; CESC cis rs1003719 0.751 rs7280371 chr21:38450008 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.64 0.47 5.56e-16 Eye color traits; CESC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg06028605 chr16:24865363 SLC5A11 0.54 7.43 0.42 1.49e-12 Intelligence (multi-trait analysis); CESC cis rs6088590 1.000 rs6087632 chr20:33407704 A/C cg06115741 chr20:33292138 TP53INP2 0.61 7.59 0.42 5.47e-13 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19237607 chr20:36156146 BLCAP 0.56 6.12 0.35 3.3e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg24881330 chr22:46731750 TRMU 0.77 6.19 0.36 2.26e-9 LDL cholesterol;Cholesterol, total; CESC cis rs9457247 0.602 rs17615336 chr6:167506734 A/G cg07741184 chr6:167504864 NA 0.39 6.65 0.38 1.7e-10 Crohn's disease; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg13099106 chr12:120525172 CCDC64 -0.47 -6.1 -0.35 3.7e-9 Height; CESC cis rs3813567 0.759 rs7163204 chr15:78953740 G/A cg24631222 chr15:78858424 CHRNA5 0.48 5.25 0.31 3.13e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs1775715 0.870 rs1775735 chr10:32255846 A/G cg04359828 chr10:32216031 ARHGAP12 0.35 5.17 0.3 4.72e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.82 -9.14 -0.49 1.66e-17 Gut microbiome composition (summer); CESC cis rs35160687 0.644 rs4832272 chr2:86516211 A/G cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.17 -0.3 4.72e-7 Night sleep phenotypes; CESC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg08027265 chr7:2291960 NA 0.35 5.32 0.31 2.2e-7 Bipolar disorder and schizophrenia; CESC cis rs9611565 0.559 rs5758428 chr22:42106216 G/A cg03806693 chr22:41940476 POLR3H 1.15 13.6 0.64 2.54e-32 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07310536 chr10:103892743 PPRC1 0.62 6.57 0.37 2.6200000000000003e-10 Gut microbiome composition (summer); CESC cis rs12579753 0.879 rs12829053 chr12:82161926 T/A cg24719984 chr12:82153464 PPFIA2 -0.36 -5.33 -0.31 2.11e-7 Resting heart rate; CESC cis rs7100689 0.599 rs6585968 chr10:82139807 T/C cg00277334 chr10:82204260 NA -0.59 -7.8 -0.43 1.4e-13 Post bronchodilator FEV1; CESC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg24549020 chr5:56110836 MAP3K1 0.59 6.95 0.39 2.75e-11 Initial pursuit acceleration; CESC cis rs10924970 0.649 rs6697580 chr1:235484609 T/A cg26050004 chr1:235667680 B3GALNT2 0.44 5.11 0.3 6.16e-7 Asthma; CESC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg02564969 chr6:151773285 C6orf211;RMND1 0.66 9.47 0.5 1.67e-18 Menarche (age at onset); CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.19 -0.36 2.27e-9 Depression; CESC cis rs7666738 0.830 rs13115356 chr4:98933171 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.673 rs17826219 chr17:29161845 G/A cg19761014 chr17:28927070 LRRC37B2 0.72 5.68 0.33 3.48e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9300255 0.544 rs10772995 chr12:123671761 T/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.21 -0.36 2.01e-9 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09832218 chr12:56694334 CS -0.62 -6.85 -0.39 5.24e-11 Gut microbiome composition (summer); CESC cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg03433033 chr1:76189801 ACADM 0.7 9.38 0.5 2.99e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg21017887 chr14:105400489 NA 0.41 6.64 0.38 1.81e-10 Rheumatoid arthritis; CESC cis rs55788414 0.932 rs12102691 chr16:81181460 G/T cg06400318 chr16:81190750 PKD1L2 -0.6 -7.07 -0.4 1.38e-11 Left ventricular obstructive tract defect (maternal effect); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15420785 chr6:34216928 C6orf1 0.56 6.91 0.39 3.58e-11 Gut microbiome composition (summer); CESC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg24739457 chr1:205821442 NA 0.39 5.35 0.31 1.88e-7 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27104117 chr17:27276789 PHF12 0.6 7.24 0.41 4.75e-12 Gut microbiome composition (summer); CESC cis rs13108904 0.905 rs1732108 chr4:1276550 C/T cg00684032 chr4:1343700 KIAA1530 -0.37 -5.18 -0.3 4.37e-7 Obesity-related traits; CESC cis rs1707322 0.963 rs6666763 chr1:46436451 C/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6951245 0.810 rs117800627 chr7:1081075 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.05 -0.3 8.15e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6542838 0.554 rs4311103 chr2:99538362 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.43 -5.57 -0.32 6.3e-8 Fear of minor pain; CESC cis rs12541635 0.677 rs34872724 chr8:107033071 C/T cg10147462 chr8:107024639 NA -0.47 -7.07 -0.4 1.39e-11 Age of smoking initiation; CESC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg17724175 chr1:150552817 MCL1 -0.39 -6.08 -0.35 4.07e-9 Melanoma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09829838 chr6:42952307 PPP2R5D -0.39 -6.09 -0.35 4.06e-9 Gambling; CESC cis rs7091068 0.518 rs4144098 chr10:95432600 C/T cg20715218 chr10:95462985 C10orf4 0.47 6.07 0.35 4.47e-9 Urinary tract infection frequency; CESC cis rs6598955 0.694 rs4659416 chr1:26580937 T/G cg04990556 chr1:26633338 UBXN11 -0.75 -10.68 -0.55 2.29e-22 Obesity-related traits; CESC trans rs6582630 0.533 rs4103689 chr12:38702980 A/C cg23762105 chr12:34175262 ALG10 -0.49 -6.58 -0.37 2.46e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs6714710 0.580 rs35564270 chr2:98602165 A/G cg26665480 chr2:98280029 ACTR1B 0.54 7.28 0.41 3.85e-12 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs72945132 0.825 rs57871058 chr11:70192344 T/C cg00319359 chr11:70116639 PPFIA1 0.72 6.94 0.39 3.1e-11 Coronary artery disease; CESC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg02569458 chr12:86230093 RASSF9 0.48 6.97 0.39 2.56e-11 Major depressive disorder; CESC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg22535103 chr8:58192502 C8orf71 -0.99 -10.43 -0.54 1.42e-21 Developmental language disorder (linguistic errors); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03348573 chr5:133304316 C5orf15 -0.49 -6.43 -0.37 5.98e-10 Ulcerative colitis; CESC cis rs12478296 1.000 rs6739247 chr2:243039189 C/A cg06360820 chr2:242988706 NA -0.66 -7.53 -0.42 8.09e-13 Obesity-related traits; CESC cis rs798554 0.704 rs709282 chr7:2769921 G/A cg19717773 chr7:2847554 GNA12 -0.56 -8.77 -0.47 2.25e-16 Height; CESC cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg17366294 chr4:99064904 C4orf37 0.58 8.36 0.46 3.62e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1322639 0.806 rs1322640 chr6:169586887 T/C cg03254818 chr6:169586852 NA -0.53 -7.21 -0.41 5.71e-12 Pulse pressure; CESC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg08470875 chr2:26401718 FAM59B 0.76 8.06 0.44 2.69e-14 Gut microbiome composition (summer); CESC cis rs4975616 0.869 rs401681 chr5:1322087 C/T cg26373071 chr5:1325741 CLPTM1L 0.42 6.73 0.38 1.05e-10 Lung cancer; CESC cis rs10754283 0.901 rs10047070 chr1:90098715 G/C cg21401794 chr1:90099060 LRRC8C 0.69 9.16 0.49 1.45e-17 Amyotrophic lateral sclerosis (sporadic); CESC cis rs55728055 0.661 rs73162106 chr22:32034875 A/G cg01338084 chr22:32026380 PISD 1.21 8.55 0.47 9.91e-16 Age-related hearing impairment; CESC cis rs2456568 0.548 rs4402256 chr11:93660803 T/C cg26875233 chr11:93583750 C11orf90 -0.32 -5.55 -0.32 7.1e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC trans rs11722228 0.522 rs7681250 chr4:10133013 G/T cg26043149 chr18:55253948 FECH 1.0 12.65 0.61 5.33e-29 Gout;Urate levels;Serum uric acid levels; CESC cis rs62229266 0.804 rs2835231 chr21:37390598 C/T cg08632701 chr21:37451849 NA -0.37 -5.12 -0.3 6.01e-7 Mitral valve prolapse; CESC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs2011503 0.941 rs6511027 chr19:19391851 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.49 5.12 0.3 6.01e-7 Bipolar disorder; CESC trans rs10435719 0.899 rs9693925 chr8:11789963 A/G cg15556689 chr8:8085844 FLJ10661 0.52 6.48 0.37 4.4e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs11168351 0.927 rs10875716 chr12:48389023 C/T cg04545296 chr12:48745243 ZNF641 0.35 5.94 0.34 8.72e-9 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09664812 chr18:9475361 RALBP1 -0.67 -7.91 -0.44 7.03e-14 Gut microbiome composition (summer); CESC cis rs9303401 0.659 rs12946852 chr17:57013337 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.98 12.19 0.6 1.93e-27 Cognitive test performance; CESC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg16545954 chr1:2118288 C1orf86 0.37 7.24 0.41 4.83e-12 Height; CESC cis rs6866344 0.568 rs10516147 chr5:178094484 A/G cg03877680 chr5:178157825 ZNF354A 0.6 6.74 0.38 9.93e-11 Neutrophil percentage of white cells; CESC cis rs4692589 0.965 rs733672 chr4:170950243 C/A cg19918862 chr4:170955249 NA 0.38 6.04 0.35 5.16e-9 Anxiety disorder; CESC cis rs2242116 0.734 rs4683294 chr3:46979013 C/G cg27129171 chr3:47204927 SETD2 -0.48 -6.49 -0.37 4.24e-10 Birth weight; CESC cis rs2735413 0.958 rs7192416 chr16:78063143 C/T cg04733911 chr16:78082701 NA -0.48 -7.75 -0.43 2.03e-13 Systolic blood pressure (alcohol consumption interaction); CESC cis rs1538970 1.000 rs61791368 chr1:45867944 T/C cg05343316 chr1:45956843 TESK2 0.85 11.62 0.58 1.69e-25 Platelet count; CESC cis rs8114671 0.562 rs6120746 chr20:33448496 A/G cg07148914 chr20:33460835 GGT7 0.48 6.36 0.36 8.83e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11490987 chr7:149535717 ZNF862 0.52 6.07 0.35 4.43e-9 Gut microbiome composition (summer); CESC cis rs6460942 0.731 rs75994414 chr7:12307992 C/A cg20607287 chr7:12443886 VWDE -0.76 -8.16 -0.45 1.34e-14 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24117104 chr4:149366997 NA -0.46 -6.59 -0.38 2.36e-10 Gut microbiota (bacterial taxa); CESC cis rs3540 0.533 rs2352601 chr15:91053125 G/A cg10434728 chr15:90938212 IQGAP1 -0.41 -7.26 -0.41 4.36e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26714410 chr13:45150072 TSC22D1 -0.44 -6.2 -0.36 2.14e-9 Gambling; CESC cis rs6598955 0.671 rs10493030 chr1:26561856 T/C cg19743891 chr1:26644573 UBXN11;CD52 0.38 5.44 0.32 1.21e-7 Obesity-related traits; CESC cis rs1707322 0.721 rs28501477 chr1:46199084 A/G cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8014252 0.667 rs12588623 chr14:70817914 C/T cg03123320 chr1:229394665 NA -0.49 -6.27 -0.36 1.45e-9 Plasma estrone levels in resected estrogen-receptor positive breast cancer; CESC cis rs9902453 0.845 rs12452201 chr17:28214173 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.12 0.45 1.77e-14 Coffee consumption (cups per day); CESC cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg17366294 chr4:99064904 C4orf37 0.62 8.8 0.48 1.82e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4523957 0.583 rs2641438 chr17:2017786 C/G cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9905704 0.633 rs8068455 chr17:56589381 C/T cg12560992 chr17:57184187 TRIM37 -0.64 -6.04 -0.35 5.11e-9 Testicular germ cell tumor; CESC cis rs13385 0.769 rs7703595 chr5:139611190 A/C cg26211634 chr5:139558579 C5orf32 0.46 5.22 0.31 3.67e-7 Atrial fibrillation; CESC cis rs1059312 1.000 rs7135987 chr12:129280117 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.73 -10.24 -0.53 6.08e-21 Systemic lupus erythematosus; CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg10150615 chr22:24372951 LOC391322 -0.54 -7.23 -0.41 5.19e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10955642 chr7:99699603 MCM7;AP4M1 0.64 7.43 0.42 1.49e-12 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01691987 chr17:7789028 CHD3 0.46 6.14 0.35 3e-9 Fibrinogen levels; CESC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg14703610 chr5:56206110 C5orf35 0.52 6.75 0.38 9.51e-11 Coronary artery disease; CESC cis rs10779751 0.959 rs2300091 chr1:11266711 C/T cg08854313 chr1:11322531 MTOR 0.91 14.23 0.66 1.56e-34 Body mass index; CESC cis rs1348850 0.526 rs7607073 chr2:178375065 C/A cg22681709 chr2:178499509 PDE11A -0.5 -5.16 -0.3 4.97e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7659604 0.540 rs4240264 chr4:122683818 A/G cg19671926 chr4:122722719 EXOSC9 0.6 7.69 0.43 2.87e-13 Type 2 diabetes; CESC cis rs644799 1.000 rs557079 chr11:95530125 C/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 6.29 0.36 1.32e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2637266 1.000 rs12251862 chr10:78367929 A/G cg18941641 chr10:78392320 NA 0.42 8.09 0.44 2.18e-14 Pulmonary function; CESC cis rs8077577 0.895 rs11871491 chr17:18105656 T/C cg16794390 chr17:18148240 FLII 0.41 5.59 0.32 5.53e-8 Obesity-related traits; CESC cis rs2070488 0.965 rs2284820 chr3:38562579 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.9 -16.54 -0.71 1.1e-42 Electrocardiographic conduction measures; CESC cis rs7605827 0.930 rs3792579 chr2:15534723 A/G cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs17253792 0.822 rs113692713 chr14:56087424 C/T cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs4319547 0.760 rs61954973 chr12:123074168 T/C cg23029597 chr12:123009494 RSRC2 -0.49 -5.41 -0.32 1.41e-7 Body mass index; CESC cis rs2073300 1.000 rs6048810 chr20:23446429 G/A cg12062639 chr20:23401060 NAPB 0.74 5.43 0.32 1.3e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1577917 1.000 rs34581302 chr6:86705948 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.34 -0.36 9.79e-10 Response to antipsychotic treatment; CESC cis rs17209837 1.000 rs60123540 chr7:87085182 T/C cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC cis rs950776 0.518 rs1979907 chr15:78842239 T/C cg24631222 chr15:78858424 CHRNA5 0.39 5.06 0.3 7.77e-7 Sudden cardiac arrest; CESC cis rs1538970 0.924 rs1006216 chr1:45909994 A/G cg05343316 chr1:45956843 TESK2 0.89 12.04 0.59 6.22e-27 Platelet count; CESC cis rs11122272 0.735 rs2295420 chr1:231485640 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.74 -0.43 2.14e-13 Hemoglobin concentration; CESC cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg11742103 chr11:62369870 EML3;MTA2 0.56 8.09 0.45 2.1e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs3087591 1.000 rs1800845 chr17:29703438 C/G cg24425628 chr17:29625626 OMG;NF1 -0.44 -5.48 -0.32 1e-7 Hip circumference; CESC cis rs12291225 0.546 rs12795545 chr11:14355564 G/A cg19336497 chr11:14380999 RRAS2 -0.44 -6.6 -0.38 2.28e-10 Sense of smell; CESC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg11644478 chr21:40555479 PSMG1 0.51 7.05 0.4 1.59e-11 Menarche (age at onset); CESC cis rs1124376 1.000 rs61457790 chr3:20136186 G/A cg05072819 chr3:20081367 KAT2B 0.54 5.89 0.34 1.14e-8 Bipolar disorder and schizophrenia; CESC cis rs10752881 1.000 rs8179283 chr1:182974602 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 13.12 0.63 1.19e-30 Colorectal cancer; CESC cis rs920590 0.758 rs35280191 chr8:19665214 A/C cg03894339 chr8:19674705 INTS10 0.67 7.83 0.43 1.15e-13 Acute lymphoblastic leukemia (childhood); CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg08984023 chr10:64133896 ZNF365 0.38 6.11 0.35 3.6e-9 Post-traumatic stress disorder; CESC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg25036284 chr2:26402008 FAM59B 0.86 9.4 0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs9611565 0.694 rs5758411 chr22:42079734 G/A cg03806693 chr22:41940476 POLR3H 0.75 9.02 0.48 3.84e-17 Vitiligo; CESC trans rs4756846 1.000 rs55820833 chr11:16400359 A/T cg05579622 chr5:10618622 ANKRD33B 0.76 6.93 0.39 3.14e-11 Obesity and osteoporosis; CESC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.31 -5.08 -0.3 6.96e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs8014204 0.901 rs6574200 chr14:75364451 C/T cg08847533 chr14:75593920 NEK9 -0.43 -5.38 -0.31 1.64e-7 Caffeine consumption; CESC cis rs13102973 0.932 rs28801464 chr4:135876630 A/G cg14419869 chr4:135874104 NA -0.37 -5.7 -0.33 3.19e-8 Subjective well-being; CESC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg05368731 chr17:41323189 NBR1 0.78 11.02 0.56 1.73e-23 Menopause (age at onset); CESC trans rs637571 0.522 rs538954 chr11:65756808 A/G cg17712092 chr4:129076599 LARP1B 0.74 10.42 0.54 1.61e-21 Eosinophil percentage of white cells; CESC trans rs2727020 0.731 rs10450572 chr11:49281073 T/C cg15704280 chr7:45808275 SEPT13 0.88 14.46 0.66 2.45e-35 Coronary artery disease; CESC cis rs1385374 0.858 rs12321643 chr12:129302867 A/T cg21616243 chr12:129299702 MGC16384;SLC15A4 0.6 5.22 0.31 3.61e-7 Systemic lupus erythematosus; CESC cis rs2985684 1.000 rs2985697 chr14:50092902 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.47 -5.45 -0.32 1.13e-7 Carotid intima media thickness; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg11905131 chr22:24372483 LOC391322 -0.75 -10.81 -0.55 8.09e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1538970 1.000 rs2050884 chr1:45830824 A/G cg06784218 chr1:46089804 CCDC17 0.31 5.29 0.31 2.62e-7 Platelet count; CESC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg14703610 chr5:56206110 C5orf35 -0.57 -7.67 -0.43 3.26e-13 Coronary artery disease; CESC cis rs9788682 1.000 rs61204066 chr15:78815298 G/A cg06917634 chr15:78832804 PSMA4 -0.55 -6.37 -0.36 8.16e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs3809863 0.602 rs7225700 chr17:45391804 T/C cg25173405 chr17:45401733 C17orf57 -0.53 -6.89 -0.39 4e-11 Glaucoma (primary open-angle); CESC cis rs40363 0.951 rs72778117 chr16:3531827 T/C cg05754148 chr16:3507555 NAT15 0.69 7.62 0.42 4.56e-13 Tuberculosis; CESC cis rs12476592 0.602 rs6736411 chr2:63674060 G/A cg17519650 chr2:63277830 OTX1 -0.46 -5.3 -0.31 2.47e-7 Childhood ear infection; CESC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg18876405 chr7:65276391 NA 0.45 6.09 0.35 3.92e-9 Aortic root size; CESC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg02564969 chr6:151773285 C6orf211;RMND1 0.63 8.72 0.47 3.15e-16 Menarche (age at onset); CESC cis rs9300255 0.543 rs1617156 chr12:123590165 T/C cg05973401 chr12:123451056 ABCB9 0.58 6.33 0.36 1.07e-9 Neutrophil percentage of white cells; CESC trans rs352242 0.686 rs9317800 chr13:69850652 A/C cg15456293 chr8:2044148 MYOM2 -0.35 -6.03 -0.35 5.55e-9 Life satisfaction; CESC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg04166393 chr7:2884313 GNA12 0.57 7.6 0.42 5.03e-13 Height; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg03497419 chr3:37034654 EPM2AIP1;MLH1 0.45 6.49 0.37 4.19e-10 Positive affect; CESC cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.98 0.35 7.02e-9 Colonoscopy-negative controls vs population controls; CESC cis rs55883249 1.000 rs11676903 chr2:9763201 G/C cg23886495 chr2:9695866 ADAM17 0.61 5.41 0.32 1.4e-7 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.42 5.11 0.3 6.17e-7 Bipolar disorder; CESC cis rs854765 0.583 rs11650890 chr17:17790882 C/T cg09796270 chr17:17721594 SREBF1 -0.46 -6.46 -0.37 5.04e-10 Total body bone mineral density; CESC cis rs2404602 0.679 rs12908421 chr15:76881794 T/G cg26408565 chr15:76604113 ETFA -0.4 -5.71 -0.33 3.03e-8 Blood metabolite levels; CESC cis rs6991838 0.584 rs2048650 chr8:66537899 A/G cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC trans rs8057939 0.593 rs1345473 chr16:49405649 T/C cg15532236 chr6:170188124 NA 0.55 6.43 0.37 5.91e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs7216064 0.954 rs9907491 chr17:65949993 G/A cg12091567 chr17:66097778 LOC651250 0.72 8.17 0.45 1.3e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg11060661 chr22:24314208 DDT;DDTL 0.32 5.12 0.3 5.92e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg01988459 chr11:68622903 NA -0.4 -5.3 -0.31 2.45e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg22968622 chr17:43663579 NA 1.3 17.9 0.74 1.66e-47 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs5760092 0.755 rs4585126 chr22:24270005 T/C cg24846343 chr22:24311635 DDTL -0.4 -5.75 -0.33 2.4e-8 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs4481887 1.000 rs4244178 chr1:248468441 A/G cg00666640 chr1:248458726 OR2T12 0.4 6.57 0.37 2.7e-10 Common traits (Other); CESC cis rs2228479 0.850 rs17227263 chr16:89810598 G/A cg00800038 chr16:89945340 TCF25 -0.88 -7.36 -0.41 2.3e-12 Skin colour saturation; CESC cis rs1023500 0.552 rs133368 chr22:42463689 T/C cg04733989 chr22:42467013 NAGA 0.78 11.67 0.58 1.18e-25 Schizophrenia; CESC cis rs9300255 0.679 rs12829456 chr12:123725395 C/T cg00376283 chr12:123451042 ABCB9 -0.63 -6.57 -0.37 2.66e-10 Neutrophil percentage of white cells; CESC cis rs9303401 0.659 rs62083525 chr17:56658088 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.93 0.62 5.59e-30 Cognitive test performance; CESC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg00800038 chr16:89945340 TCF25 -0.89 -7.33 -0.41 2.79e-12 Skin colour saturation; CESC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg23283495 chr1:209979779 IRF6 0.52 7.59 0.42 5.58e-13 Cleft lip with or without cleft palate; CESC cis rs8180040 0.764 rs11716539 chr3:47186503 G/T cg27129171 chr3:47204927 SETD2 0.72 11.24 0.57 3.23e-24 Colorectal cancer; CESC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg20307385 chr11:47447363 PSMC3 0.69 8.97 0.48 5.36e-17 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01745522 chr6:26217416 HIST1H2BG;HIST1H2AE 0.59 6.79 0.38 7.38e-11 Gut microbiome composition (summer); CESC cis rs7165102 0.770 rs635728 chr15:65789389 G/A cg11441148 chr15:65824328 PTPLAD1 -0.32 -5.32 -0.31 2.2e-7 Mean corpuscular hemoglobin; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19716462 chr2:62115576 CCT4 -0.49 -6.13 -0.35 3.14e-9 Asthma; CESC cis rs6424115 0.830 rs1130321 chr1:24200524 C/T cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg04317338 chr11:64019027 PLCB3 0.86 8.94 0.48 6.64e-17 Mean platelet volume; CESC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg04166393 chr7:2884313 GNA12 0.62 8.56 0.47 9.25e-16 Height; CESC cis rs708547 0.836 rs1277287 chr4:57853147 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.61 -6.86 -0.39 4.91e-11 Response to bleomycin (chromatid breaks); CESC cis rs826838 0.967 rs826855 chr12:39114888 T/C cg13010199 chr12:38710504 ALG10B -0.46 -6.44 -0.37 5.5e-10 Heart rate; CESC cis rs16866061 1.000 rs11694987 chr2:225397409 C/G cg12698349 chr2:225449008 CUL3 0.66 9.82 0.52 1.33e-19 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs921968 0.643 rs3932856 chr2:219320207 C/A cg02176678 chr2:219576539 TTLL4 0.43 7.65 0.43 3.82e-13 Mean corpuscular hemoglobin concentration; CESC cis rs13095912 0.819 rs11918734 chr3:185296602 T/C cg11274856 chr3:185301563 NA 0.37 5.5 0.32 8.96e-8 Systolic blood pressure; CESC cis rs6460942 1.000 rs2053381 chr7:12400710 C/A cg02935154 chr7:12443704 VWDE -0.56 -6.09 -0.35 3.85e-9 Coronary artery disease; CESC cis rs1707322 0.686 rs3014236 chr1:46091305 T/C cg03146154 chr1:46216737 IPP -0.8 -11.05 -0.56 1.34e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.09 0.3 6.92e-7 Personality dimensions; CESC cis rs57506017 0.585 rs5011439 chr7:12268811 G/C cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.62e-7 Neuroticism; CESC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.41e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17742757 0.522 rs899364 chr8:11329544 G/T cg03403963 chr8:11986501 LOC392196;FAM66D -0.4 -5.14 -0.3 5.45e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2797160 1.000 rs1777195 chr6:126006861 A/C cg05901451 chr6:126070800 HEY2 0.45 6.49 0.37 4.24e-10 Endometrial cancer; CESC cis rs9649465 0.967 rs13230230 chr7:123329603 G/A cg04330084 chr7:123175371 IQUB -0.38 -5.16 -0.3 4.75e-7 Migraine; CESC cis rs477692 0.673 rs556253 chr10:131355781 G/A cg05714579 chr10:131428358 MGMT 0.39 5.06 0.3 7.71e-7 Response to temozolomide; CESC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg23281280 chr6:28129359 ZNF389 0.56 7.61 0.42 4.91e-13 Depression; CESC cis rs2486288 0.656 rs8039354 chr15:45551756 A/G cg21132104 chr15:45694354 SPATA5L1 0.54 6.59 0.38 2.36e-10 Glomerular filtration rate; CESC cis rs67311347 1.000 rs12634013 chr3:40452388 T/C cg24209194 chr3:40518798 ZNF619 0.5 6.11 0.35 3.62e-9 Renal cell carcinoma; CESC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg03647317 chr4:187891568 NA -0.44 -6.42 -0.37 6.16e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 7.17 0.4 7.31e-12 Personality dimensions; CESC cis rs10838687 0.736 rs2242261 chr11:47266808 T/G cg25783544 chr11:47291846 MADD 0.57 6.63 0.38 1.91e-10 Proinsulin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09124081 chr1:224370616 DEGS1 0.57 6.05 0.35 4.96e-9 Gut microbiome composition (summer); CESC cis rs8141529 0.636 rs5762813 chr22:29203314 C/T cg15103426 chr22:29168792 CCDC117 0.49 5.29 0.31 2.58e-7 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07431748 chr10:99094531 FRAT2 0.6 7.09 0.4 1.2e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg17366294 chr4:99064904 C4orf37 0.62 8.85 0.48 1.3e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1348850 0.750 rs55792594 chr2:178496468 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 6.59 0.38 2.42e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg13628971 chr7:2884303 GNA12 0.64 8.37 0.46 3.33e-15 Height; CESC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.58 0.55 4.6e-22 Prudent dietary pattern; CESC cis rs698833 0.518 rs7560807 chr2:44557089 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 5.38 0.31 1.61e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg00484396 chr16:3507460 NAT15 0.43 6.91 0.39 3.71e-11 Tuberculosis; CESC cis rs6426558 0.537 rs10799381 chr1:227239746 G/T cg10327440 chr1:227177885 CDC42BPA 0.48 6.0 0.35 6.39e-9 Neutrophil percentage of white cells; CESC cis rs2180341 0.814 rs9401958 chr6:127736357 T/G cg27446573 chr6:127587934 RNF146 0.83 12.03 0.59 6.99e-27 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20332866 chr1:100678932 DBT -0.64 -6.71 -0.38 1.16e-10 Gut microbiome composition (summer); CESC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg08027265 chr7:2291960 NA -0.41 -6.32 -0.36 1.1e-9 Bipolar disorder and schizophrenia; CESC cis rs6089584 1.000 rs6089580 chr20:60558976 G/A cg13770153 chr20:60521292 NA -0.45 -5.9 -0.34 1.12e-8 Body mass index; CESC cis rs9894429 0.546 rs55917554 chr17:79608776 T/C cg13777783 chr17:79615861 NA -0.36 -5.79 -0.34 1.94e-8 Eye color traits; CESC cis rs7264396 0.563 rs59064961 chr20:34307950 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.65 -0.55 2.79e-22 Total cholesterol levels; CESC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg13628971 chr7:2884303 GNA12 0.64 8.23 0.45 8.41e-15 Height; CESC cis rs7520050 0.807 rs6429576 chr1:46216575 T/C cg24296786 chr1:45957014 TESK2 -0.48 -6.19 -0.36 2.27e-9 Red blood cell count;Reticulocyte count; CESC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg10883421 chr6:151773342 RMND1;C6orf211 0.83 13.36 0.63 1.78e-31 Menarche (age at onset); CESC cis rs9929218 0.911 rs1075959 chr16:68832750 A/G cg02972257 chr16:68554789 NA 0.5 5.83 0.34 1.64e-8 Colorectal cancer; CESC cis rs854765 0.583 rs11656840 chr17:17837354 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.17 0.45 1.3e-14 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12931157 chr6:41040265 C6orf130;NFYA -0.47 -6.7 -0.38 1.25e-10 Fibrinogen levels; CESC cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg07636037 chr3:49044803 WDR6 1.07 19.9 0.77 1.54e-54 Parkinson's disease; CESC cis rs240764 0.725 rs11155477 chr6:100935505 T/A cg21058520 chr6:100914733 NA 0.39 6.05 0.35 5.04e-9 Neuroticism; CESC cis rs300703 0.542 rs189762 chr2:180079 A/T cg21211680 chr2:198530 NA -0.86 -9.41 -0.5 2.5e-18 Blood protein levels; CESC cis rs11718455 1.000 rs9854785 chr3:44031295 A/G cg08738300 chr3:44038990 NA 0.45 6.1 0.35 3.68e-9 Coronary artery disease; CESC cis rs10927875 0.722 rs1763605 chr1:16338925 T/G cg22431228 chr1:16359049 CLCNKA -0.48 -7.83 -0.43 1.15e-13 Dilated cardiomyopathy; CESC cis rs3733585 0.673 rs10000983 chr4:9951606 T/C cg02734326 chr4:10020555 SLC2A9 -0.41 -5.76 -0.33 2.34e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg11764359 chr7:65958608 NA -0.7 -9.25 -0.49 7.64e-18 Aortic root size; CESC cis rs17376456 0.877 rs9314095 chr5:93425495 T/C cg25358565 chr5:93447407 FAM172A 1.14 11.29 0.57 2.12e-24 Diabetic retinopathy; CESC trans rs6845865 1.000 rs6845865 chr4:148974602 A/G cg10775173 chr7:151534032 PRKAG2 -0.42 -6.1 -0.35 3.74e-9 QT interval;Resting heart rate; CESC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg13175981 chr1:150552382 MCL1 -0.4 -5.04 -0.3 8.56e-7 Tonsillectomy; CESC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg00166722 chr3:10149974 C3orf24 0.54 6.89 0.39 4.08e-11 Alzheimer's disease; CESC trans rs1814175 0.645 rs1851845 chr11:49982396 C/T cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs643506 0.874 rs613292 chr11:111668805 C/T cg17089665 chr11:111648010 NA -0.38 -5.55 -0.32 7.03e-8 Breast cancer; CESC cis rs748404 0.697 rs531910 chr15:43560607 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.77 0.43 1.69e-13 Lung cancer; CESC trans rs17685 0.712 rs9800948 chr7:75810473 A/G cg19862616 chr7:65841803 NCRNA00174 0.81 11.17 0.57 5.3e-24 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2228479 0.850 rs11648689 chr16:89806732 G/A cg19635926 chr16:89946313 TCF25 0.68 5.06 0.3 7.81e-7 Skin colour saturation; CESC cis rs34779708 0.931 rs10466072 chr10:35402756 C/T cg03585969 chr10:35415529 CREM 0.79 10.48 0.54 1.04e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs6088580 0.543 rs13042351 chr20:33238573 G/A cg08999081 chr20:33150536 PIGU -0.44 -6.27 -0.36 1.48e-9 Glomerular filtration rate (creatinine); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17838705 chr1:112298602 DDX20;C1orf183 0.42 6.02 0.35 5.89e-9 Gut microbiota (bacterial taxa); CESC cis rs62103177 0.733 rs62096748 chr18:77619699 T/C cg12964065 chr18:77638022 KCNG2 0.57 5.63 0.33 4.7e-8 Opioid sensitivity; CESC cis rs9399135 0.933 rs9389262 chr6:135376409 G/T cg24558204 chr6:135376177 HBS1L 0.52 7.19 0.4 6.44e-12 Red blood cell count; CESC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg12463550 chr7:65579703 CRCP 0.56 7.07 0.4 1.33e-11 Aortic root size; CESC cis rs7923609 0.818 rs10822159 chr10:65096250 C/T cg01631684 chr10:65280961 REEP3 -0.43 -5.38 -0.31 1.66e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs73568641 0.546 rs6899940 chr6:154085465 A/C cg08374472 chr16:87445639 ZCCHC14 -0.46 -6.2 -0.36 2.14e-9 Methadone dose in opioid dependence; CESC trans rs3857536 0.605 rs36040831 chr6:66876588 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.72 -10.18 -0.53 9.34e-21 Blood trace element (Cu levels); CESC cis rs17384381 0.859 rs12130591 chr1:85904985 C/T cg16011679 chr1:85725395 C1orf52 0.65 6.8 0.39 7.11e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9811920 0.695 rs793497 chr3:99505610 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.45 -7.26 -0.41 4.26e-12 Axial length; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg00508498 chr11:34378805 ABTB2 0.43 6.37 0.36 8.48e-10 Post-traumatic stress disorder; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg19900852 chr14:35451793 SRP54 0.45 6.02 0.35 5.7e-9 Bronchopulmonary dysplasia; CESC cis rs10225163 0.590 rs10266923 chr7:27918229 C/T cg05786569 chr7:27702416 HIBADH -0.4 -5.03 -0.3 9.21e-7 Gout; CESC cis rs9915657 0.660 rs12602039 chr17:70089384 A/G cg09344028 chr17:70110421 NA 0.38 6.83 0.39 5.84e-11 Thyroid hormone levels; CESC cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg21226059 chr5:178986404 RUFY1 0.38 5.33 0.31 2.12e-7 Lung cancer; CESC cis rs9300255 0.739 rs2337934 chr12:123745359 A/G cg00376283 chr12:123451042 ABCB9 0.71 8.91 0.48 8.4e-17 Neutrophil percentage of white cells; CESC cis rs9303401 0.659 rs7224276 chr17:56897827 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.5 0.61 1.71e-28 Cognitive test performance; CESC cis rs7617773 0.817 rs17647717 chr3:48305456 C/T cg11946769 chr3:48343235 NME6 0.86 11.22 0.57 3.67e-24 Coronary artery disease; CESC cis rs1348850 0.608 rs10176632 chr2:178225934 G/T cg23306229 chr2:178417860 TTC30B 0.48 6.0 0.35 6.62e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4481887 1.000 rs4244172 chr1:248466838 A/G cg00666640 chr1:248458726 OR2T12 0.39 6.49 0.37 4.25e-10 Common traits (Other); CESC cis rs568617 1.000 rs694994 chr11:65653309 A/G cg00576331 chr11:65640516 EFEMP2 -0.46 -5.45 -0.32 1.15e-7 Crohn's disease; CESC cis rs1465370 0.682 rs7811409 chr7:130024701 G/C cg04743876 chr7:130013617 NA 0.3 5.66 0.33 3.97e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs3126085 0.935 rs1858480 chr1:152301735 A/G cg03465714 chr1:152285911 FLG 0.43 5.46 0.32 1.11e-7 Atopic dermatitis; CESC cis rs1348850 0.914 rs7573763 chr2:178249808 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.9 13.2 0.63 6.71e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg26314531 chr2:26401878 FAM59B -0.59 -6.67 -0.38 1.5e-10 Gut microbiome composition (summer); CESC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg07507251 chr3:52567010 NT5DC2 0.43 7.33 0.41 2.79e-12 Bipolar disorder; CESC cis rs9916302 0.861 rs3889368 chr17:37683231 C/T cg07936489 chr17:37558343 FBXL20 -0.8 -11.56 -0.58 2.74e-25 Glomerular filtration rate (creatinine); CESC cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg26116260 chr4:7069785 GRPEL1 0.98 14.65 0.67 5.14e-36 Monocyte percentage of white cells; CESC cis rs2839186 0.504 rs11702278 chr21:47936295 T/G cg10657630 chr21:48055338 PRMT2 0.45 5.69 0.33 3.38e-8 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17505757 chr17:5323140 RPAIN;NUP88 -0.56 -6.28 -0.36 1.42e-9 Gut microbiome composition (summer); CESC cis rs7520050 0.966 rs1707336 chr1:46493460 T/G cg03146154 chr1:46216737 IPP -0.47 -6.08 -0.35 4.25e-9 Red blood cell count;Reticulocyte count; CESC cis rs6598955 0.543 rs60676610 chr1:26543421 G/C cg04990556 chr1:26633338 UBXN11 0.82 9.16 0.49 1.45e-17 Obesity-related traits; CESC cis rs933688 0.877 rs1477349 chr5:90707773 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 14.23 0.66 1.63e-34 Smoking behavior; CESC cis rs10883723 0.810 rs10883728 chr10:104269301 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.56 -7.81 -0.43 1.33e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs7216064 1.000 rs58122682 chr17:65876915 T/C cg12091567 chr17:66097778 LOC651250 -0.86 -8.82 -0.48 1.55e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10883723 0.810 rs7074343 chr10:104283165 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.18 0.3 4.34e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs3015497 0.562 rs8011264 chr14:51091499 A/T cg26011998 chr14:51135199 SAV1 -0.51 -5.63 -0.33 4.48e-8 Mean platelet volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11563264 chr4:190862026 FRG1 -0.48 -6.2 -0.36 2.18e-9 Ulcerative colitis; CESC cis rs7086627 0.515 rs7088877 chr10:82208860 C/G cg03267442 chr10:82210566 NA -0.34 -5.6 -0.33 5.45e-8 Post bronchodilator FEV1; CESC trans rs7615952 0.673 rs16834637 chr3:125605471 C/T cg07211511 chr3:129823064 LOC729375 -0.86 -8.99 -0.48 4.82e-17 Blood pressure (smoking interaction); CESC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.65 0.33 4.12e-8 Bipolar disorder; CESC cis rs1865721 1.000 rs8094181 chr18:73193976 T/A cg26385618 chr18:73139727 C18orf62 -0.51 -7.56 -0.42 6.81e-13 Intelligence; CESC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.08 -0.3 7.05e-7 Bipolar disorder; CESC cis rs10465746 0.935 rs11580836 chr1:84333310 C/T cg10977910 chr1:84465055 TTLL7 0.48 6.52 0.37 3.64e-10 Obesity-related traits; CESC cis rs12368653 1.000 rs12371356 chr12:58135420 T/C cg02175503 chr12:58329896 NA -0.39 -5.11 -0.3 6.28e-7 Multiple sclerosis; CESC cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.11 0.49 2.15e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4700695 0.719 rs27587 chr5:65444163 C/T cg21114390 chr5:65439923 SFRS12 -0.51 -6.17 -0.35 2.52e-9 Facial morphology (factor 19); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03288803 chr16:88690881 ZC3H18 -0.53 -6.47 -0.37 4.79e-10 Gut microbiome composition (summer); CESC cis rs2769264 0.602 rs11204777 chr1:151072049 G/A cg03258749 chr1:151040405 MLLT11 -0.55 -6.97 -0.39 2.49e-11 Blood trace element (Cu levels); CESC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg11657440 chr19:46296263 DMWD 0.79 12.35 0.6 5.72e-28 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12178287 chr19:17631836 PGLS -0.58 -6.24 -0.36 1.73e-9 Gut microbiome composition (summer); CESC trans rs1853207 1.000 rs74154119 chr10:96632871 C/T cg02968918 chr4:184908541 STOX2 0.61 6.23 0.36 1.8e-9 Blood metabolite levels; CESC cis rs7193541 0.859 rs12598791 chr16:74500745 A/C cg01733217 chr16:74700730 RFWD3 0.78 10.64 0.55 3.06e-22 Multiple myeloma; CESC trans rs4671386 0.901 rs6708756 chr2:60521398 G/C cg24386296 chr4:1723849 TMEM129;TACC3 0.49 6.17 0.35 2.54e-9 Acne (severe); CESC cis rs748404 0.697 rs493444 chr15:43566470 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.59 7.87 0.44 9.34e-14 Lung cancer; CESC cis rs287982 0.932 rs9973654 chr2:9962568 C/A cg10881225 chr2:9984929 TAF1B 0.4 5.13 0.3 5.69e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs10206020 0.842 rs7590900 chr2:1574902 A/G cg26248373 chr2:1572462 NA -0.59 -6.93 -0.39 3.22e-11 IgG glycosylation; CESC cis rs5758659 0.845 rs5758645 chr22:42598951 T/G cg04733989 chr22:42467013 NAGA 0.41 5.62 0.33 4.79e-8 Cognitive function; CESC cis rs7918232 0.941 rs1755399 chr10:27394958 A/G cg14240646 chr10:27532245 ACBD5 -0.68 -6.35 -0.36 9.2e-10 Breast cancer; CESC cis rs1008375 1.000 rs4642241 chr4:17617111 T/C cg16339924 chr4:17578868 LAP3 0.54 6.76 0.38 8.56e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03654001 chr7:100812981 NA 0.42 6.39 0.37 7.32e-10 Systemic lupus erythematosus; CESC cis rs9309473 0.500 rs4852952 chr2:73869907 T/C cg20560298 chr2:73613845 ALMS1 0.46 6.36 0.36 8.78e-10 Metabolite levels; CESC cis rs1355223 1.000 rs1396883 chr11:34757447 C/T cg11058730 chr11:34937778 PDHX;APIP -0.46 -5.95 -0.34 8.52e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs561341 1.000 rs560132 chr17:30320019 C/T cg00745463 chr17:30367425 LRRC37B -0.86 -7.83 -0.43 1.21e-13 Hip circumference adjusted for BMI; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19531713 chr17:41277059 BRCA1;NBR2 0.5 6.49 0.37 4.22e-10 Gut microbiota (bacterial taxa); CESC cis rs4843747 0.749 rs12102841 chr16:88072574 C/G cg03395651 chr16:88107091 BANP -0.42 -5.03 -0.3 9.2e-7 Menopause (age at onset); CESC cis rs7582720 0.943 rs72936839 chr2:203773237 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6496667 0.509 rs2253419 chr15:90945875 A/G cg22089800 chr15:90895588 ZNF774 0.48 6.19 0.36 2.29e-9 Rheumatoid arthritis; CESC cis rs6831352 0.918 rs2602894 chr4:100045647 A/G cg13256891 chr4:100009986 ADH5 0.74 8.13 0.45 1.63e-14 Alcohol dependence; CESC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg24675658 chr1:53192096 ZYG11B -0.66 -9.16 -0.49 1.46e-17 Monocyte count; CESC cis rs17293817 0.617 rs12764264 chr10:1411526 A/G cg04271617 chr10:1416546 ADARB2 0.34 5.27 0.31 2.76e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg12564285 chr5:131593104 PDLIM4 0.39 5.98 0.34 7.2e-9 Breast cancer; CESC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg13206674 chr6:150067644 NUP43 0.45 6.53 0.37 3.37e-10 Lung cancer; CESC cis rs644799 0.932 rs572015 chr11:95637416 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.47 5.86 0.34 1.38e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6539267 0.741 rs7314289 chr12:106686260 A/C cg02476566 chr12:106696527 TCP11L2 0.59 6.88 0.39 4.41e-11 Tourette syndrome; CESC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg13902645 chr11:5959945 NA -0.67 -8.81 -0.48 1.73e-16 DNA methylation (variation); CESC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg18099408 chr3:52552593 STAB1 -0.32 -5.17 -0.3 4.55e-7 Bipolar disorder; CESC cis rs7618501 1.000 rs2234391 chr3:49842625 A/G cg24308560 chr3:49941425 MST1R -0.5 -6.74 -0.38 9.71e-11 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21400344 chr1:25870172 LDLRAP1 -0.45 -6.03 -0.35 5.36e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26353328 chr8:42010408 AP3M2 0.57 6.49 0.37 4.16e-10 Gut microbiome composition (summer); CESC cis rs858239 0.712 rs199650 chr7:23367189 C/T cg23682824 chr7:23144976 KLHL7 -0.41 -5.43 -0.32 1.28e-7 Cerebrospinal fluid biomarker levels; CESC cis rs1387259 0.929 rs11168460 chr12:48597365 A/G cg24011408 chr12:48396354 COL2A1 0.43 6.11 0.35 3.5e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg07701084 chr6:150067640 NUP43 0.44 5.97 0.34 7.65e-9 Lung cancer; CESC cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7818688 1.000 rs28406132 chr8:96030377 C/T cg16049864 chr8:95962084 TP53INP1 0.61 5.78 0.33 2.13e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9487051 0.714 rs1546722 chr6:109625797 A/G cg21918786 chr6:109611834 NA -0.36 -5.29 -0.31 2.58e-7 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11971027 chr1:153651147 NPR1 0.6 6.65 0.38 1.7e-10 Gut microbiome composition (summer); CESC cis rs524281 0.861 rs7931544 chr11:65917034 C/T cg14036092 chr11:66035641 RAB1B -0.58 -5.86 -0.34 1.35e-8 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06414596 chr16:58232216 CSNK2A2 0.55 6.13 0.35 3.2e-9 Gut microbiome composition (summer); CESC cis rs4654899 0.758 rs6702331 chr1:21516107 A/T cg05370193 chr1:21551575 ECE1 0.39 6.08 0.35 4.23e-9 Superior frontal gyrus grey matter volume; CESC cis rs151349 1.000 rs108727 chr20:57584890 C/T cg23907860 chr20:57583709 CTSZ 0.41 6.59 0.38 2.34e-10 Platelet distribution width; CESC cis rs4727027 0.901 rs34201592 chr7:148842403 C/G cg23158103 chr7:148848205 ZNF398 -0.41 -6.57 -0.37 2.65e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.77 11.65 0.58 1.33e-25 Monocyte percentage of white cells; CESC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg14926445 chr8:58193284 C8orf71 -0.5 -5.4 -0.31 1.49e-7 Developmental language disorder (linguistic errors); CESC trans rs9467711 0.606 rs34550936 chr6:26361985 A/G cg06606381 chr12:133084897 FBRSL1 -0.76 -7.08 -0.4 1.28e-11 Autism spectrum disorder or schizophrenia; CESC cis rs6032067 0.632 rs35361894 chr20:43794403 G/A cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs763121 0.925 rs9835 chr22:39130971 A/G cg06022373 chr22:39101656 GTPBP1 0.72 11.48 0.58 5.11e-25 Menopause (age at onset); CESC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg21782813 chr7:2030301 MAD1L1 0.39 5.49 0.32 9.33e-8 Bipolar disorder and schizophrenia; CESC cis rs6541297 0.645 rs4846919 chr1:230301451 A/G cg20703242 chr1:230279135 GALNT2 0.56 6.6 0.38 2.29e-10 Coronary artery disease; CESC cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg25517755 chr10:38738941 LOC399744 -0.46 -5.98 -0.34 7.38e-9 Extrinsic epigenetic age acceleration; CESC cis rs6570726 0.870 rs370653 chr6:145823642 G/A cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22561380 chr8:42829775 HOOK3 -0.66 -8.0 -0.44 3.98e-14 Gut microbiome composition (summer); CESC cis rs2599510 0.811 rs176413 chr2:32646847 G/A cg02381751 chr2:32503542 YIPF4 -0.5 -6.39 -0.37 7.35e-10 Interleukin-18 levels; CESC cis rs9790314 0.967 rs9821201 chr3:160996155 G/C cg04691961 chr3:161091175 C3orf57 -0.41 -5.27 -0.31 2.87e-7 Morning vs. evening chronotype; CESC cis rs6582630 0.512 rs11181007 chr12:38266700 C/T cg26384229 chr12:38710491 ALG10B -0.43 -5.56 -0.32 6.46e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg16325326 chr1:53192061 ZYG11B -0.7 -11.23 -0.57 3.43e-24 Monocyte count; CESC cis rs7264396 0.690 rs2425178 chr20:34446395 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.57 -0.58 2.56e-25 Total cholesterol levels; CESC cis rs6446731 0.593 rs2858083 chr4:3272331 T/A cg08886695 chr4:3369023 RGS12 -0.37 -5.32 -0.31 2.23e-7 Mean platelet volume; CESC cis rs11098499 0.604 rs2389882 chr4:120566733 A/C cg24375607 chr4:120327624 NA 0.46 5.73 0.33 2.76e-8 Corneal astigmatism; CESC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.57 -7.23 -0.41 5.33e-12 Tonsillectomy; CESC trans rs11658311 0.850 rs60149982 chr17:17667240 A/G cg01883427 chr16:15242839 NA 0.55 6.22 0.36 1.96e-9 Obsessive-compulsive symptoms; CESC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg09658497 chr7:2847517 GNA12 -0.37 -5.28 -0.31 2.72e-7 Height; CESC cis rs737337 0.623 rs4804155 chr19:11334295 C/G cg00586551 chr19:11347513 LOC55908;DOCK6 0.51 6.22 0.36 1.97e-9 HDL cholesterol;HDL cholesterol levels; CESC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg17971929 chr21:40555470 PSMG1 1.03 15.86 0.7 2.81e-40 Cognitive function; CESC cis rs921968 0.565 rs4674330 chr2:219595710 T/C cg02176678 chr2:219576539 TTLL4 -0.43 -7.55 -0.42 7.04e-13 Mean corpuscular hemoglobin concentration; CESC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg23281280 chr6:28129359 ZNF389 0.59 8.18 0.45 1.15e-14 Depression; CESC cis rs10882165 0.547 rs12264655 chr10:94951798 A/G cg00992348 chr10:94926053 NA -0.31 -5.39 -0.31 1.57e-7 Refractive error; CESC cis rs6088580 0.634 rs6120650 chr20:33039973 G/A cg08999081 chr20:33150536 PIGU 0.65 11.42 0.57 7.86e-25 Glomerular filtration rate (creatinine); CESC cis rs7208859 0.673 rs9912122 chr17:29140716 C/A cg13385521 chr17:29058706 SUZ12P 0.59 5.49 0.32 9.51e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7116495 0.609 rs2276384 chr11:71701523 A/G cg10381502 chr11:71823885 C11orf51 1.01 6.97 0.39 2.46e-11 Severe influenza A (H1N1) infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15583012 chr2:204103676 CYP20A1 -0.48 -6.66 -0.38 1.58e-10 Fibrinogen levels; CESC cis rs12476592 0.602 rs4671508 chr2:63654140 C/T cg17519650 chr2:63277830 OTX1 -0.47 -5.26 -0.31 2.93e-7 Childhood ear infection; CESC cis rs2320614 0.679 rs72631678 chr4:164102715 G/A cg15586945 chr4:164088095 NAF1 -0.58 -7.56 -0.42 6.75e-13 Lung adenocarcinoma; CESC cis rs5753618 0.583 rs5753632 chr22:31863097 C/T cg02404636 chr22:31891804 SFI1 0.43 6.04 0.35 5.21e-9 Colorectal cancer; CESC cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg20476274 chr7:133979776 SLC35B4 0.68 10.07 0.53 2.09e-20 Mean platelet volume; CESC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.83 0.39 5.96e-11 Bipolar disorder; CESC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs42648 0.935 rs42659 chr7:89981958 A/G cg23697855 chr7:89950296 NA 0.28 5.3 0.31 2.42e-7 Homocysteine levels; CESC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.76 0.65 7.11e-33 Prudent dietary pattern; CESC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.5 0.37 4.04e-10 Bipolar disorder; CESC cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg11764359 chr7:65958608 NA -0.83 -10.16 -0.53 1.05e-20 Aortic root size; CESC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.61 0.42 4.95e-13 Prudent dietary pattern; CESC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg07677032 chr17:61819896 STRADA -0.44 -5.75 -0.33 2.48e-8 Prudent dietary pattern; CESC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg16680214 chr1:154839983 KCNN3 -0.44 -6.71 -0.38 1.14e-10 Prostate cancer; CESC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.12 0.53 1.44e-20 Prudent dietary pattern; CESC cis rs9814567 1.000 rs6801596 chr3:134252114 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.82 -0.34 1.69e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs17253792 0.822 rs13379340 chr14:56050346 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.86 0.34 1.36e-8 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16260977 chr19:3761708 MRPL54;APBA3 0.62 7.22 0.41 5.36e-12 Gut microbiome composition (summer); CESC cis rs117623576 0.941 rs60146023 chr10:32411515 G/A cg03047570 chr10:32398778 NA -0.73 -7.72 -0.43 2.44e-13 Anti-saccade response; CESC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg00080972 chr5:178986291 RUFY1 0.39 5.86 0.34 1.35e-8 Lung cancer; CESC cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.87 0.34 1.32e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6547741 0.904 rs2384659 chr2:27856793 G/A cg27432699 chr2:27873401 GPN1 0.46 6.37 0.36 8.38e-10 Oral cavity cancer; CESC cis rs2797685 0.898 rs2071987 chr1:7834026 G/A cg04725166 chr1:7887271 PER3 -0.41 -5.59 -0.32 5.54e-8 Crohn's disease; CESC cis rs9488822 0.597 rs12214881 chr6:116342187 G/T cg26893134 chr6:116381904 FRK 0.25 6.14 0.35 3.03e-9 Cholesterol, total;LDL cholesterol; CESC cis rs7959452 0.684 rs11177615 chr12:69754189 G/A cg20891283 chr12:69753455 YEATS4 0.88 13.97 0.65 1.29e-33 Blood protein levels; CESC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.67 -0.33 3.74e-8 Total body bone mineral density; CESC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg27165867 chr14:105738592 BRF1 -0.55 -5.89 -0.34 1.14e-8 Mean platelet volume;Platelet distribution width; CESC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.51 0.37 3.8e-10 Prudent dietary pattern; CESC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.42 -5.4 -0.31 1.51e-7 Tonsillectomy; CESC trans rs11722228 0.508 rs2241473 chr4:10085949 G/A cg26043149 chr18:55253948 FECH 0.9 11.07 0.56 1.19e-23 Gout;Urate levels;Serum uric acid levels; CESC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC cis rs96067 0.528 rs274131 chr1:36582925 C/T cg27506609 chr1:36549197 TEKT2 -0.42 -6.15 -0.35 2.77e-9 Corneal structure; CESC cis rs1348850 0.632 rs11678875 chr2:178509068 A/G cg22681709 chr2:178499509 PDE11A -0.57 -8.97 -0.48 5.43e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs113835537 0.529 rs57691879 chr11:66236604 C/T cg22134325 chr11:66188745 NPAS4 0.33 5.08 0.3 7.01e-7 Airway imaging phenotypes; CESC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg06420487 chr17:61919686 SMARCD2 0.46 5.51 0.32 8.47e-8 Height; CESC cis rs3105593 1.000 rs11070800 chr15:50907347 C/T cg08437265 chr15:50716283 USP8 0.4 5.13 0.3 5.69e-7 QT interval; CESC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg10691866 chr7:65817282 TPST1 -0.33 -5.28 -0.31 2.74e-7 Aortic root size; CESC cis rs9303280 0.747 rs1453559 chr17:38020419 T/C cg20243544 chr17:37824526 PNMT 0.49 6.6 0.38 2.22e-10 Self-reported allergy; CESC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.41 -0.37 6.51e-10 Depression; CESC cis rs11098499 0.863 rs36040693 chr4:120477616 A/G cg24375607 chr4:120327624 NA 0.45 5.54 0.32 7.33e-8 Corneal astigmatism; CESC cis rs765787 0.530 rs4775822 chr15:45527127 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs12477438 0.798 rs4851179 chr2:99568774 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.82 -0.55 7.58e-23 Chronic sinus infection; CESC cis rs7208859 0.524 rs8065744 chr17:29099449 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9914988 0.832 rs11650788 chr17:27174523 T/A cg20469991 chr17:27169893 C17orf63 -0.44 -5.24 -0.31 3.2e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC trans rs10776614 0.799 rs1345110 chr10:49765168 G/A cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs13191362 0.507 rs13197051 chr6:163201728 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.5 5.93 0.34 9.18e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1483890 0.723 rs12631128 chr3:69411416 G/T cg22125112 chr3:69402811 FRMD4B 0.39 5.15 0.3 5.15e-7 Resting heart rate; CESC cis rs7814319 0.966 rs10112328 chr8:97254372 C/T cg20787634 chr8:97240163 UQCRB 0.53 6.94 0.39 3.08e-11 Lung function (FVC); CESC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg10691866 chr7:65817282 TPST1 0.33 5.53 0.32 7.81e-8 Aortic root size; CESC cis rs2243480 1.000 rs34136756 chr7:65381256 A/G cg13147721 chr7:65941812 NA -0.85 -8.1 -0.45 2e-14 Diabetic kidney disease; CESC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg21770322 chr7:97807741 LMTK2 0.55 8.3 0.45 5.53e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.87 0.62 9.38e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs890470 chr4:98923435 A/C cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg22217807 chr16:8768618 ABAT -0.49 -6.49 -0.37 4.26e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23121547 chr11:1593657 HCCA2;LOC338651;DUSP8 0.59 7.35 0.41 2.53e-12 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg22920501 chr2:26401640 FAM59B 0.89 9.73 0.51 2.53e-19 Gut microbiome composition (summer); CESC cis rs9300255 0.569 rs1790115 chr12:123620270 C/G cg05973401 chr12:123451056 ABCB9 0.53 5.91 0.34 1.04e-8 Neutrophil percentage of white cells; CESC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.87e-17 Tonsillectomy; CESC cis rs10754283 0.967 rs7546410 chr1:90109815 C/T cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg17366294 chr4:99064904 C4orf37 -0.61 -8.62 -0.47 5.98e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6665290 0.935 rs6693535 chr1:227197685 G/A cg10327440 chr1:227177885 CDC42BPA -1.22 -33.0 -0.9 7.42e-96 Myeloid white cell count; CESC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 9.85 0.52 1.04e-19 Prudent dietary pattern; CESC cis rs7647973 0.626 rs2329021 chr3:49679072 G/A cg06212747 chr3:49208901 KLHDC8B 0.64 7.75 0.43 1.94e-13 Menarche (age at onset); CESC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg14829155 chr15:31115871 NA 0.72 10.44 0.54 1.32e-21 Huntington's disease progression; CESC cis rs992157 0.835 rs12987180 chr2:219144089 G/A cg00012203 chr2:219082015 ARPC2 -0.76 -9.55 -0.51 9.45e-19 Colorectal cancer; CESC cis rs1881797 1.000 rs1881796 chr1:247688931 G/A cg18198730 chr1:247681584 NA 0.59 7.77 0.43 1.76e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs724767 1.000 rs73065951 chr3:193721651 T/A cg01524723 chr3:193718032 NA -0.67 -6.84 -0.39 5.45e-11 Estradiol plasma levels (breast cancer); CESC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.54 -0.37 3.18e-10 Bipolar disorder; CESC cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg11752832 chr7:134001865 SLC35B4 0.55 7.23 0.41 5.27e-12 Mean platelet volume; CESC trans rs7690543 0.681 rs6552068 chr4:67994467 A/G cg05505961 chr17:66375071 ARSG -0.52 -6.13 -0.35 3.13e-9 Glucose homeostasis traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11574758 chr20:21107113 PLK1S1 -0.44 -6.31 -0.36 1.15e-9 Gambling; CESC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 11.71 0.58 8.43e-26 Platelet count; CESC cis rs6120849 0.901 rs13037296 chr20:33749228 T/A cg24642439 chr20:33292090 TP53INP2 0.6 6.42 0.37 6.21e-10 Protein C levels; CESC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs1801251 1.000 rs36007169 chr2:233621834 A/G cg25237894 chr2:233734115 C2orf82 0.45 7.9 0.44 7.6e-14 Coronary artery disease; CESC cis rs3740713 1.000 rs16935424 chr11:18456737 A/T cg23797887 chr11:18477753 LDHAL6A -0.53 -5.27 -0.31 2.89e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs793571 0.715 rs11071399 chr15:59139255 A/G cg05156742 chr15:59063176 FAM63B -0.52 -6.34 -0.36 9.64e-10 Schizophrenia; CESC cis rs3015497 0.603 rs2934684 chr14:51058234 G/T cg26011998 chr14:51135199 SAV1 -0.48 -5.44 -0.32 1.2e-7 Mean platelet volume; CESC cis rs854765 0.547 rs2955370 chr17:17966945 C/T cg16928487 chr17:17741425 SREBF1 0.55 9.21 0.49 9.96e-18 Total body bone mineral density; CESC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg22823121 chr1:150693482 HORMAD1 0.47 7.03 0.4 1.73e-11 Melanoma; CESC cis rs12188164 0.515 rs11744936 chr5:412112 C/T cg26850624 chr5:429559 AHRR -0.45 -5.94 -0.34 8.72e-9 Cystic fibrosis severity; CESC cis rs939658 0.805 rs35291410 chr15:79438660 C/T cg17916960 chr15:79447300 NA -0.37 -6.15 -0.35 2.8e-9 Refractive error; CESC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg10691866 chr7:65817282 TPST1 -0.34 -5.51 -0.32 8.3e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22887498 chr19:39401301 NA -0.53 -6.18 -0.35 2.34e-9 Gut microbiome composition (summer); CESC cis rs7520050 0.966 rs11810993 chr1:46478793 A/G cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.23e-8 Red blood cell count;Reticulocyte count; CESC cis rs360798 0.553 rs11682530 chr2:63073194 C/T cg17519650 chr2:63277830 OTX1 -0.6 -7.71 -0.43 2.52e-13 Coronary artery disease; CESC cis rs9486715 0.838 rs9320127 chr6:96865358 G/A cg06623918 chr6:96969491 KIAA0776 0.92 14.42 0.66 3.55e-35 Headache; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26534993 chr2:3291401 TSSC1 -0.61 -6.69 -0.38 1.3100000000000001e-10 Gut microbiome composition (summer); CESC cis rs9858542 0.953 rs9827708 chr3:49649989 C/G cg07274523 chr3:49395745 GPX1 0.66 8.59 0.47 7.45e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg10645314 chr2:3704589 ALLC -0.47 -5.34 -0.31 2.02e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg27094323 chr7:1216898 NA -0.38 -5.23 -0.31 3.4e-7 Longevity;Endometriosis; CESC cis rs863345 0.967 rs4477267 chr1:158470644 C/T cg12129480 chr1:158549410 OR10X1 -0.31 -6.19 -0.36 2.34e-9 Pneumococcal bacteremia; CESC cis rs72781680 0.821 rs12623521 chr2:24181670 C/T cg08917208 chr2:24149416 ATAD2B 0.66 6.5 0.37 3.98e-10 Lymphocyte counts; CESC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg05368731 chr17:41323189 NBR1 0.78 11.02 0.56 1.73e-23 Menopause (age at onset); CESC cis rs854765 0.547 rs4643387 chr17:17972973 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.53 6.82 0.39 6.26e-11 Total body bone mineral density; CESC cis rs9715521 0.867 rs7437815 chr4:59826005 T/C cg11281224 chr4:60001000 NA -0.5 -6.53 -0.37 3.38e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6502050 0.835 rs56095560 chr17:80151304 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.56e-7 Life satisfaction; CESC trans rs17613427 1.000 rs16846186 chr2:142242486 G/C cg16810031 chr17:38024146 ZPBP2 -0.9 -6.22 -0.36 1.89e-9 Left ventricle systolic dysfunction; CESC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg12373951 chr3:133503437 NA -0.38 -5.59 -0.32 5.53e-8 Iron status biomarkers; CESC trans rs11098499 0.644 rs10050092 chr4:120532085 T/C cg25214090 chr10:38739885 LOC399744 0.62 8.88 0.48 1.06e-16 Corneal astigmatism; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22442454 chr1:209979470 IRF6 0.61 9.24 0.49 8.25e-18 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs6502050 0.871 rs62079998 chr17:80077245 A/C cg23985595 chr17:80112537 CCDC57 0.4 6.33 0.36 1.05e-9 Life satisfaction; CESC cis rs748404 0.697 rs491804 chr15:43560825 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.8 0.43 1.47e-13 Lung cancer; CESC cis rs9300255 0.602 rs1716164 chr12:123663660 G/A cg05973401 chr12:123451056 ABCB9 0.5 5.74 0.33 2.53e-8 Neutrophil percentage of white cells; CESC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.45 5.68 0.33 3.55e-8 Height; CESC trans rs1814175 0.817 rs6486046 chr11:49997017 T/C cg03929089 chr4:120376271 NA -0.94 -16.03 -0.7 7.02e-41 Height; CESC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg21033440 chr11:65409861 SIPA1 -0.59 -7.18 -0.4 7.19e-12 Blood pressure (age interaction); CESC cis rs2816062 0.775 rs2745315 chr1:18897118 G/A cg18795169 chr1:18902165 NA -0.91 -17.81 -0.74 3.44e-47 Urate levels in lean individuals; CESC cis rs2075371 0.637 rs2544165 chr7:133920443 A/G cg11752832 chr7:134001865 SLC35B4 -0.51 -6.56 -0.37 2.82e-10 Mean platelet volume; CESC cis rs12477438 0.520 rs13031919 chr2:99848932 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.71 10.11 0.53 1.57e-20 Chronic sinus infection; CESC cis rs2839186 0.867 rs13050387 chr21:47701423 C/T cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 6.74e-11 Testicular germ cell tumor; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24849267 chr2:172374169 NA -0.52 -7.12 -0.4 1.04e-11 Gut microbiota (bacterial taxa); CESC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg04369109 chr6:150039330 LATS1 -0.45 -6.4 -0.37 6.93e-10 Lung cancer; CESC cis rs9911578 0.900 rs8067264 chr17:57182793 G/C cg12560992 chr17:57184187 TRIM37 1.01 17.89 0.74 1.77e-47 Intelligence (multi-trait analysis); CESC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg05368731 chr17:41323189 NBR1 -0.6 -8.11 -0.45 1.85e-14 Menopause (age at onset); CESC cis rs739401 0.572 rs410820 chr11:3080102 G/A cg08508325 chr11:3079039 CARS -0.59 -11.16 -0.57 5.74e-24 Longevity; CESC cis rs796364 0.951 rs12996313 chr2:200997916 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.69 -6.64 -0.38 1.77e-10 Schizophrenia; CESC cis rs672059 0.934 rs6703054 chr1:183155778 A/C ch.1.3577855R chr1:183094577 LAMC1 0.54 7.06 0.4 1.49e-11 Hypertriglyceridemia; CESC cis rs3008870 0.959 rs2985826 chr1:67412918 G/C cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs9487051 0.621 rs830552 chr6:109549914 A/G cg01475377 chr6:109611718 NA -0.38 -5.12 -0.3 5.74e-7 Reticulocyte fraction of red cells; CESC cis rs11191270 0.554 rs11191265 chr10:104102118 G/A cg15320455 chr10:103880129 LDB1 0.61 5.82 0.34 1.67e-8 Intelligence (multi-trait analysis); CESC cis rs897984 0.762 rs2305880 chr16:30999462 T/C cg02466173 chr16:30829666 NA 0.48 8.16 0.45 1.32e-14 Dementia with Lewy bodies; CESC cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.83 -8.25 -0.45 7.41e-15 Schizophrenia; CESC cis rs35146811 0.844 rs4729576 chr7:99692594 G/A cg22906224 chr7:99728672 NA 0.45 5.17 0.3 4.66e-7 Coronary artery disease; CESC cis rs4891159 0.790 rs77878087 chr18:74116337 G/A cg24786174 chr18:74118243 ZNF516 -0.72 -11.21 -0.57 3.84e-24 Longevity; CESC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.676 rs1521905 chr6:109594515 T/C cg12927641 chr6:109611667 NA -0.37 -5.56 -0.32 6.55e-8 Reticulocyte fraction of red cells; CESC cis rs6121246 0.559 rs6060944 chr20:30372114 G/A cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg27094323 chr7:1216898 NA -0.36 -5.17 -0.3 4.72e-7 Longevity;Endometriosis; CESC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg11301795 chr4:187892539 NA 0.75 12.13 0.6 3.12e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs2645424 1.000 rs7009302 chr8:11685981 C/G cg21281001 chr8:11725306 CTSB 0.43 5.19 0.3 4.27e-7 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); CESC cis rs910316 0.967 rs10142770 chr14:75525449 G/A cg11812906 chr14:75593930 NEK9 0.92 15.44 0.69 8.57e-39 Height; CESC cis rs7824557 0.751 rs2099456 chr8:11127001 A/C cg21775007 chr8:11205619 TDH 0.4 6.12 0.35 3.41e-9 Retinal vascular caliber; CESC cis rs7592578 0.766 rs62182865 chr2:191434180 T/C cg10560079 chr2:191398806 TMEM194B -0.65 -5.46 -0.32 1.07e-7 Diastolic blood pressure; CESC cis rs6089584 0.527 rs927589 chr20:60606363 A/G cg24733560 chr20:60626293 TAF4 0.49 7.28 0.41 3.85e-12 Body mass index; CESC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg22143856 chr6:28129313 ZNF389 0.46 5.81 0.34 1.76e-8 Depression; CESC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg04369109 chr6:150039330 LATS1 -0.41 -5.81 -0.34 1.82e-8 Lung cancer; CESC cis rs4642101 0.640 rs9877049 chr3:12821231 A/G cg24848339 chr3:12840334 CAND2 0.38 6.07 0.35 4.5e-9 QRS complex (12-leadsum); CESC trans rs3780486 0.846 rs3824458 chr9:33144809 C/T cg20290983 chr6:43655470 MRPS18A 0.97 17.29 0.73 2.29e-45 IgG glycosylation; CESC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg11764359 chr7:65958608 NA -0.71 -9.33 -0.5 4.52e-18 Aortic root size; CESC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg02841227 chr6:26021843 HIST1H4A 0.43 5.29 0.31 2.59e-7 Intelligence (multi-trait analysis); CESC cis rs4132509 1.000 rs10754807 chr1:243804158 G/A cg21452805 chr1:244014465 NA 0.43 5.08 0.3 7.3e-7 RR interval (heart rate); CESC cis rs9911578 0.704 rs72628393 chr17:56585314 A/T cg12560992 chr17:57184187 TRIM37 -0.9 -14.75 -0.67 2.37e-36 Intelligence (multi-trait analysis); CESC cis rs2228479 0.850 rs11640188 chr16:89807732 C/T cg14709524 chr16:89940631 TCF25 0.92 6.97 0.39 2.55e-11 Skin colour saturation; CESC cis rs6088590 1.000 rs12626122 chr20:33425800 A/G cg24642439 chr20:33292090 TP53INP2 0.84 11.08 0.56 1.04e-23 Coronary artery disease; CESC cis rs17253792 0.822 rs8009239 chr14:56062490 A/G cg01858014 chr14:56050164 KTN1 -0.96 -7.13 -0.4 9.72e-12 Putamen volume; CESC cis rs1448094 0.791 rs61929394 chr12:86331541 C/A cg02569458 chr12:86230093 RASSF9 0.45 6.43 0.37 5.79e-10 Major depressive disorder; CESC cis rs7605827 0.930 rs11687986 chr2:15591308 G/T cg19274914 chr2:15703543 NA 0.34 6.07 0.35 4.38e-9 Educational attainment (years of education); CESC cis rs17209837 0.667 rs45605032 chr7:87090301 C/T cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC cis rs17384381 1.000 rs12129502 chr1:85900727 T/C cg16011679 chr1:85725395 C1orf52 0.74 7.57 0.42 6.02e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs9457247 0.902 rs366938 chr6:167403538 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.83 0.34 1.58e-8 Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05425294 chr16:1644664 IFT140 0.5 6.47 0.37 4.83e-10 Fibrinogen levels; CESC cis rs17021463 0.676 rs12512832 chr4:95310216 G/T cg11021082 chr4:95130006 SMARCAD1 0.52 7.14 0.4 9.2e-12 Testicular germ cell tumor; CESC cis rs6732160 0.593 rs2288630 chr2:73457552 C/T cg01422370 chr2:73384389 NA 0.41 6.83 0.39 5.93e-11 Intelligence (multi-trait analysis); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20662616 chr2:30454643 LBH -0.43 -6.04 -0.35 5.13e-9 Height; CESC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg18230493 chr5:56204884 C5orf35 0.61 7.97 0.44 4.6e-14 Initial pursuit acceleration; CESC cis rs72634258 0.554 rs34305100 chr1:7913029 A/G cg00042356 chr1:8021962 PARK7 0.59 5.66 0.33 3.99e-8 Inflammatory bowel disease; CESC cis rs34779708 0.966 rs2505639 chr10:35474421 A/G cg04310649 chr10:35416472 CREM 0.53 6.65 0.38 1.63e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs11166927 0.901 rs7014257 chr8:140802694 G/T cg16909799 chr8:140841666 TRAPPC9 0.58 8.59 0.47 7.53e-16 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs684232 0.623 rs365118 chr17:580543 G/A cg12384639 chr17:618140 VPS53 0.42 5.41 0.32 1.4e-7 Prostate cancer; CESC cis rs9916302 0.821 rs12938268 chr17:37572139 G/A cg20243544 chr17:37824526 PNMT 0.49 5.92 0.34 9.98e-9 Glomerular filtration rate (creatinine); CESC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg23803603 chr1:2058230 PRKCZ -0.34 -5.83 -0.34 1.57e-8 Height; CESC cis rs67478160 0.619 rs2368560 chr14:104273311 C/T cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.0 -0.4 2.04e-11 Schizophrenia; CESC cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg15017067 chr4:17643749 FAM184B -0.4 -5.4 -0.32 1.45e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs79349575 0.749 rs2546491 chr17:46977916 A/G cg16584676 chr17:46985605 UBE2Z 0.53 6.58 0.37 2.57e-10 Type 2 diabetes; CESC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg05315796 chr3:52349193 DNAH1 -0.39 -6.78 -0.38 7.82e-11 Bipolar disorder; CESC cis rs7772486 0.875 rs10457793 chr6:146415403 A/G cg05347473 chr6:146136440 FBXO30 0.51 6.68 0.38 1.37e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs113835537 0.935 rs79496339 chr11:66467769 T/A cg24851651 chr11:66362959 CCS 0.66 5.87 0.34 1.27e-8 Airway imaging phenotypes; CESC cis rs782590 0.967 rs62165172 chr2:55736237 A/G cg18811423 chr2:55921094 PNPT1 0.79 12.47 0.61 2.15e-28 Metabolic syndrome; CESC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg22823121 chr1:150693482 HORMAD1 0.39 5.6 0.33 5.33e-8 Melanoma; CESC cis rs6433857 0.536 rs4625864 chr2:181353942 G/C cg23363182 chr2:181467187 NA -0.41 -5.79 -0.34 1.97e-8 Body mass index; CESC cis rs752010 0.574 rs10890161 chr1:42121623 T/C cg06885757 chr1:42089581 HIVEP3 0.47 7.64 0.43 3.89e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg10691866 chr7:65817282 TPST1 -0.35 -5.6 -0.33 5.33e-8 Aortic root size; CESC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg14393609 chr7:65229607 NA -0.41 -5.78 -0.33 2.1e-8 Aortic root size; CESC cis rs8078723 0.901 rs709591 chr17:38175561 T/A cg17467752 chr17:38218738 THRA 0.66 9.91 0.52 6.68e-20 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs9911578 1.000 rs302859 chr17:56693132 C/T cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC cis rs4319547 0.656 rs28730465 chr12:122863864 A/C cg05707623 chr12:122985044 ZCCHC8 0.56 6.3 0.36 1.22e-9 Body mass index; CESC cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 0.844 rs1555330 chr20:25232097 A/C cg24626310 chr20:25276739 ABHD12;PYGB 0.72 11.88 0.59 2.28e-26 Liver enzyme levels (alkaline phosphatase); CESC trans rs1728785 0.818 rs1069289 chr16:68585317 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.64 7.49 0.42 1.03e-12 Ulcerative colitis; CESC cis rs2415984 0.541 rs12433740 chr14:46933240 G/T cg14871534 chr14:47121158 RPL10L 0.39 5.69 0.33 3.39e-8 Number of children ever born; CESC cis rs397969 0.596 rs17605101 chr17:19877634 T/C cg12073167 chr17:19770448 ULK2 -0.51 -5.78 -0.33 2.05e-8 Platelet count; CESC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg10053473 chr17:62856997 LRRC37A3 -0.73 -7.85 -0.43 1.05e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9811920 0.809 rs1384062 chr3:99597928 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.44 5.82 0.34 1.7e-8 Axial length; CESC cis rs4243830 0.737 rs11122088 chr1:6603677 T/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -7.32 -0.41 3.05e-12 Body mass index; CESC trans rs2727020 0.563 rs10769582 chr11:49474040 T/C cg03929089 chr4:120376271 NA -0.81 -12.71 -0.62 3.17e-29 Coronary artery disease; CESC cis rs1153858 1.000 rs10519021 chr15:45631795 G/A cg21132104 chr15:45694354 SPATA5L1 0.84 11.38 0.57 1.09e-24 Homoarginine levels; CESC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg21770322 chr7:97807741 LMTK2 0.56 8.61 0.47 6.55e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs6460942 0.597 rs7808537 chr7:12520913 G/C cg02935154 chr7:12443704 VWDE -0.54 -5.44 -0.32 1.23e-7 Coronary artery disease; CESC cis rs2760061 0.659 rs708107 chr1:228189495 C/T cg01973587 chr1:228161476 NA -0.36 -5.46 -0.32 1.1e-7 Diastolic blood pressure; CESC cis rs67311347 0.824 rs59922539 chr3:40337110 G/A cg09455208 chr3:40491958 NA 0.43 7.06 0.4 1.49e-11 Renal cell carcinoma; CESC cis rs854765 0.718 rs7224815 chr17:17845800 A/T cg04398451 chr17:18023971 MYO15A -0.64 -8.64 -0.47 5.33e-16 Total body bone mineral density; CESC cis rs9467773 1.000 rs9467783 chr6:26542894 C/T cg11502198 chr6:26597334 ABT1 0.38 5.32 0.31 2.16e-7 Intelligence (multi-trait analysis); CESC cis rs2011503 0.941 rs4808934 chr19:19370917 C/T cg11584989 chr19:19387371 SF4 0.53 6.32 0.36 1.09e-9 Bipolar disorder; CESC cis rs2228479 0.850 rs17233664 chr16:89810628 C/T cg14709524 chr16:89940631 TCF25 0.94 7.08 0.4 1.27e-11 Skin colour saturation; CESC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.24 -0.41 4.79e-12 Developmental language disorder (linguistic errors); CESC cis rs698833 0.828 rs3738984 chr2:44531484 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.5 -6.35 -0.36 9.45e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.24e-39 Aortic root size; CESC cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg13798912 chr7:905769 UNC84A -0.6 -5.85 -0.34 1.44e-8 Cerebrospinal P-tau181p levels; CESC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg22764044 chr5:178986830 RUFY1 0.48 7.22 0.41 5.45e-12 Lung cancer; CESC cis rs7666738 0.546 rs10010088 chr4:98655945 C/T cg17366294 chr4:99064904 C4orf37 0.48 5.84 0.34 1.52e-8 Colonoscopy-negative controls vs population controls; CESC cis rs3820068 0.603 rs56032936 chr1:15970953 T/C cg16988262 chr1:15930761 NA 0.33 5.41 0.32 1.44e-7 Systolic blood pressure; CESC cis rs7666738 0.752 rs35436270 chr4:99088280 G/A cg05340658 chr4:99064831 C4orf37 0.61 7.1 0.4 1.17e-11 Colonoscopy-negative controls vs population controls; CESC cis rs11864453 0.611 rs9926927 chr16:72130556 G/T cg01557791 chr16:72042693 DHODH -0.43 -5.63 -0.33 4.52e-8 Fibrinogen levels; CESC cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg06582575 chr6:163149167 PACRG;PARK2 -0.78 -8.41 -0.46 2.51e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs412050 0.547 rs79111189 chr22:22164597 T/G cg17089214 chr22:22089827 YPEL1 0.68 5.74 0.33 2.53e-8 Attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11711062 chr6:132102214 NA -0.48 -6.15 -0.35 2.78e-9 Gut microbiome composition (summer); CESC cis rs748404 0.723 rs512431 chr15:43541939 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -8.23 -0.45 8.6e-15 Lung cancer; CESC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.53 -5.81 -0.34 1.79e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg07936489 chr17:37558343 FBXL20 0.75 10.39 0.54 1.96e-21 Glomerular filtration rate (creatinine); CESC cis rs698833 0.886 rs8886 chr2:44547909 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.49 -6.22 -0.36 1.98e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg11764359 chr7:65958608 NA -0.57 -7.49 -0.42 1.04e-12 Aortic root size; CESC cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg11764359 chr7:65958608 NA 0.81 9.84 0.52 1.15e-19 Aortic root size; CESC cis rs4835473 0.932 rs4260486 chr4:144908709 C/T cg25736465 chr4:144833511 NA 0.42 6.43 0.37 6.02e-10 Immature fraction of reticulocytes; CESC cis rs2243480 1.000 rs4718270 chr7:65202407 A/G cg25894440 chr7:65020034 NA -0.64 -5.33 -0.31 2.1e-7 Diabetic kidney disease; CESC cis rs11190604 1.000 rs12354411 chr10:102294537 G/A cg07080220 chr10:102295463 HIF1AN 0.7 6.5 0.37 3.99e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs6963495 0.818 rs73190166 chr7:105159955 G/A cg02135003 chr7:105160482 PUS7 -0.46 -5.38 -0.31 1.64e-7 Bipolar disorder (body mass index interaction); CESC cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.31 0.31 2.33e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7799006 0.964 rs3757440 chr7:2272936 A/G cg08027265 chr7:2291960 NA -0.44 -6.79 -0.38 7.4e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs10242455 0.702 rs59574285 chr7:99236151 C/T cg25640893 chr7:99214727 ZNF498 0.78 5.22 0.31 3.66e-7 Blood metabolite levels; CESC cis rs9790314 0.846 rs13083229 chr3:161008125 G/A cg03342759 chr3:160939853 NMD3 -0.51 -7.26 -0.41 4.27e-12 Morning vs. evening chronotype; CESC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg11766577 chr21:47581405 C21orf56 0.49 6.77 0.38 8.44e-11 Testicular germ cell tumor; CESC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg00166722 chr3:10149974 C3orf24 0.54 6.89 0.39 4.08e-11 Alzheimer's disease; CESC cis rs6690583 0.562 rs6688354 chr1:85520854 A/G cg22153463 chr1:85462885 MCOLN2 0.78 7.62 0.42 4.59e-13 Serum sulfate level; CESC cis rs2985684 0.789 rs1957979 chr14:50063332 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.46 -5.58 -0.32 6.08e-8 Carotid intima media thickness; CESC cis rs79057730 0.599 rs79272827 chr7:807015 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.92 7.99 0.44 4.08e-14 Initial pursuit acceleration; CESC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg24503407 chr1:205819492 PM20D1 0.79 12.71 0.62 3.22e-29 Menarche (age at onset); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T ch.2.1420302F chr2:62093097 NA -0.39 -6.19 -0.36 2.22e-9 Vertical cup-disc ratio; CESC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.32 0.31 2.23e-7 Bipolar disorder; CESC cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg14416269 chr4:6271139 WFS1 0.44 7.14 0.4 8.83e-12 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1707322 0.752 rs11211169 chr1:46166709 A/G cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2034088 0.833 rs4968120 chr17:431364 T/G cg13332499 chr17:408570 NA 0.49 8.61 0.47 6.72e-16 Hip circumference adjusted for BMI; CESC cis rs3096299 0.802 rs3102336 chr16:89442006 C/T cg08392591 chr16:89556376 ANKRD11 0.39 5.06 0.3 7.98e-7 Multiple myeloma (IgH translocation); CESC cis rs4835473 0.897 rs4054616 chr4:144758625 T/A cg25736465 chr4:144833511 NA 0.45 6.65 0.38 1.67e-10 Immature fraction of reticulocytes; CESC cis rs7824557 0.564 rs2572392 chr8:11235605 T/G cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.43e-14 Retinal vascular caliber; CESC cis rs2243480 0.901 rs3813708 chr7:65305632 C/A cg13147721 chr7:65941812 NA -0.91 -8.71 -0.47 3.41e-16 Diabetic kidney disease; CESC cis rs7116495 0.609 rs4477459 chr11:71720616 T/C cg18441811 chr11:71824068 C11orf51 -0.81 -5.37 -0.31 1.74e-7 Severe influenza A (H1N1) infection; CESC cis rs561341 0.709 rs8068049 chr17:30183857 T/C cg00745463 chr17:30367425 LRRC37B 0.69 6.15 0.35 2.82e-9 Hip circumference adjusted for BMI; CESC cis rs7089973 0.604 rs1359079 chr10:116582502 A/G cg23260525 chr10:116636907 FAM160B1 0.38 6.86 0.39 4.82e-11 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2070488 1.000 rs1002676 chr3:38444932 A/C cg24069376 chr3:38537580 EXOG -0.45 -8.06 -0.44 2.58e-14 Electrocardiographic conduction measures; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10561472 chr19:4066818 ZBTB7A -0.57 -6.33 -0.36 1.07e-9 Gut microbiome composition (summer); CESC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg17724175 chr1:150552817 MCL1 -0.48 -7.67 -0.43 3.31e-13 Urate levels; CESC trans rs9354308 0.933 rs12194424 chr6:66574007 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 7.79 0.43 1.56e-13 Metabolite levels; CESC cis rs892961 0.932 rs747481 chr17:75412143 A/G cg05865280 chr17:75406074 SEPT9 0.62 12.7 0.62 3.53e-29 Airflow obstruction; CESC cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.09 11.08 0.56 1.09e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg23758822 chr17:41437982 NA 1.03 16.04 0.7 6.23e-41 Menopause (age at onset); CESC cis rs34779708 0.966 rs4934536 chr10:35441169 A/G cg04310649 chr10:35416472 CREM -0.51 -6.21 -0.36 2.08e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg02297831 chr4:17616191 MED28 -0.53 -6.31 -0.36 1.18e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6500395 1.000 rs1004909 chr16:48725580 C/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.32 -0.36 1.13e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs2380220 0.720 rs9398251 chr6:95984709 C/T cg04719120 chr6:96025338 MANEA 0.45 5.06 0.3 7.88e-7 Behavioural disinhibition (generation interaction); CESC cis rs7953508 0.506 rs3782415 chr12:93967755 T/C cg18151635 chr12:93972918 NA -0.44 -5.87 -0.34 1.31e-8 Pubertal anthropometrics; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04570540 chr13:113383816 ATP11A -0.48 -6.41 -0.37 6.82e-10 Systemic lupus erythematosus; CESC cis rs2839186 0.967 rs17176131 chr21:47705237 T/C cg10351095 chr21:47802916 PCNT -0.49 -6.68 -0.38 1.42e-10 Testicular germ cell tumor; CESC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg03934478 chr11:495069 RNH1 0.56 5.39 0.31 1.54e-7 Body mass index; CESC cis rs7851660 0.654 rs2120264 chr9:100645728 A/G cg13688889 chr9:100608707 NA -0.61 -8.66 -0.47 4.59e-16 Strep throat; CESC trans rs1977584 0.673 rs17416363 chr10:45392198 C/T cg09262100 chr14:103416268 CDC42BPB 0.61 6.1 0.35 3.67e-9 Selective IgA deficiency; CESC cis rs2243480 1.000 rs1546059 chr7:65654709 C/A cg13147721 chr7:65941812 NA 0.97 9.16 0.49 1.47e-17 Diabetic kidney disease; CESC cis rs910316 0.763 rs175057 chr14:75489632 C/T cg08847533 chr14:75593920 NEK9 -0.89 -14.97 -0.68 3.77e-37 Height; CESC cis rs1348850 0.540 rs6737342 chr2:178419117 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.7 6.81 0.39 6.62e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs71636778 0.543 rs17162330 chr1:27236212 A/G cg12203394 chr1:27248618 NUDC 0.64 5.55 0.32 6.82e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg22800045 chr5:56110881 MAP3K1 0.79 9.22 0.49 9.3e-18 Initial pursuit acceleration; CESC cis rs7107174 1.000 rs2512533 chr11:77968674 A/C cg02023728 chr11:77925099 USP35 0.48 6.34 0.36 9.87e-10 Testicular germ cell tumor; CESC cis rs2228479 0.557 rs11641726 chr16:89891619 G/A cg14709524 chr16:89940631 TCF25 0.87 6.05 0.35 4.99e-9 Skin colour saturation; CESC cis rs7223966 1.000 rs9895920 chr17:61852719 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.36 0.41 2.28e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg07414643 chr4:187882934 NA 0.56 8.14 0.45 1.53e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs826838 0.967 rs826876 chr12:39123843 T/C cg26384229 chr12:38710491 ALG10B -0.67 -11.02 -0.56 1.72e-23 Heart rate; CESC trans rs66887589 0.807 rs7694483 chr4:120405929 T/A cg25214090 chr10:38739885 LOC399744 0.43 6.09 0.35 3.92e-9 Diastolic blood pressure; CESC cis rs11051970 0.625 rs2728709 chr12:32567716 C/T cg24626660 chr12:32551988 NA 0.32 5.04 0.3 8.57e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1775715 0.870 rs3847414 chr10:32219176 A/G cg18675610 chr10:32216311 ARHGAP12 0.35 5.25 0.31 3.1e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7923609 0.967 rs3740331 chr10:65192288 G/A cg01631684 chr10:65280961 REEP3 -0.44 -5.48 -0.32 9.84e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg25204440 chr1:209979598 IRF6 0.56 5.51 0.32 8.42e-8 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23845400 chr6:36343668 ETV7 -0.56 -6.21 -0.36 2.02e-9 Gut microbiome composition (summer); CESC cis rs243505 0.528 rs740951 chr7:148470160 C/A cg09806900 chr7:148480153 CUL1 0.44 5.24 0.31 3.3e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs2033732 0.826 rs2196617 chr8:85089394 G/A cg05716166 chr8:85095498 RALYL 0.32 5.09 0.3 6.67e-7 Body mass index; CESC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg04369109 chr6:150039330 LATS1 -0.48 -6.6 -0.38 2.26e-10 Lung cancer; CESC trans rs6089829 0.962 rs6062393 chr20:61663230 G/A cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23332732 chr12:26986274 ITPR2 -0.46 -6.01 -0.35 6.19e-9 Fibrinogen levels; CESC cis rs4654899 0.758 rs6426665 chr1:21382205 T/C cg05370193 chr1:21551575 ECE1 0.35 5.33 0.31 2.07e-7 Superior frontal gyrus grey matter volume; CESC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg07701084 chr6:150067640 NUP43 0.43 5.54 0.32 7.12e-8 Lung cancer; CESC cis rs9549367 0.789 rs3764125 chr13:113897648 A/G cg00898013 chr13:113819073 PROZ 0.58 7.67 0.43 3.26e-13 Platelet distribution width; CESC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg18769074 chr3:133464867 TF 0.32 5.97 0.34 7.63e-9 Iron status biomarkers; CESC trans rs116095464 0.558 rs10076655 chr5:239464 G/C cg00938859 chr5:1591904 SDHAP3 0.63 6.92 0.39 3.43e-11 Breast cancer; CESC cis rs3820068 0.532 rs72645862 chr1:15920366 A/G cg16988262 chr1:15930761 NA 0.36 5.67 0.33 3.63e-8 Systolic blood pressure; CESC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg00684032 chr4:1343700 KIAA1530 0.39 5.43 0.32 1.27e-7 Obesity-related traits; CESC cis rs4835473 0.897 rs61611095 chr4:144879955 C/A cg25736465 chr4:144833511 NA 0.41 6.11 0.35 3.59e-9 Immature fraction of reticulocytes; CESC cis rs9303280 0.685 rs9916765 chr17:38005595 T/C cg20243544 chr17:37824526 PNMT 0.5 6.88 0.39 4.34e-11 Self-reported allergy; CESC cis rs941873 0.805 rs876678 chr10:81111036 G/T cg08514558 chr10:81106712 PPIF 0.3 5.23 0.31 3.5e-7 Height; CESC cis rs761746 0.607 rs5753715 chr22:31991001 G/A cg25791279 chr22:32026902 PISD 0.57 5.71 0.33 2.96e-8 Intelligence; CESC cis rs690037 0.551 rs690522 chr3:16377067 C/T cg23474789 chr3:16306055 DPH3;OXNAD1 -0.46 -6.06 -0.35 4.56e-9 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); CESC cis rs7520050 0.966 rs785492 chr1:46583607 G/A cg24296786 chr1:45957014 TESK2 0.41 5.17 0.3 4.55e-7 Red blood cell count;Reticulocyte count; CESC cis rs977987 0.735 rs166013 chr16:75434146 C/T cg03315344 chr16:75512273 CHST6 -0.44 -6.11 -0.35 3.46e-9 Dupuytren's disease; CESC cis rs36051895 0.664 rs11793659 chr9:5109707 A/G cg02405213 chr9:5042618 JAK2 -0.53 -6.13 -0.35 3.25e-9 Pediatric autoimmune diseases; CESC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg19418458 chr7:158789849 NA -0.5 -8.26 -0.45 6.78e-15 Facial morphology (factor 20); CESC cis rs4555082 0.874 rs28785556 chr14:105745388 A/T cg06808227 chr14:105710500 BRF1 -0.52 -5.53 -0.32 7.68e-8 Mean platelet volume;Platelet distribution width; CESC cis rs4727963 0.846 rs10258817 chr7:122738914 G/A cg03640110 chr7:122635026 TAS2R16 0.37 5.76 0.33 2.32e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs7336332 0.598 rs10220056 chr13:28003781 T/G cg22138327 chr13:27999177 GTF3A 0.64 5.96 0.34 8.09e-9 Weight; CESC cis rs1559088 0.600 rs7259117 chr19:33550113 G/T cg17764715 chr19:33622953 WDR88 0.59 8.28 0.45 6.31e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7103648 0.553 rs12803857 chr11:47890172 G/A cg03711944 chr11:47377212 SPI1 -0.34 -5.15 -0.3 5.02e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs6939532 0.522 rs2073528 chr6:26375143 G/C cg14345882 chr6:26364793 BTN3A2 0.38 6.03 0.35 5.54e-9 Autism spectrum disorder or schizophrenia; CESC cis rs1707322 0.752 rs28812624 chr1:46203736 T/A cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg00339695 chr16:24857497 SLC5A11 0.5 6.53 0.37 3.25e-10 Intelligence (multi-trait analysis); CESC cis rs3213545 0.659 rs2259693 chr12:121457995 G/A cg15155738 chr12:121454335 C12orf43 0.5 6.07 0.35 4.35e-9 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg14829155 chr15:31115871 NA -0.72 -9.72 -0.51 2.73e-19 Huntington's disease progression; CESC cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.48 6.2 0.36 2.21e-9 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15623359 chr2:73441816 SMYD5 -0.68 -7.96 -0.44 5.01e-14 Gut microbiome composition (summer); CESC cis rs12586317 0.547 rs28577270 chr14:35498443 G/A cg05294307 chr14:35346193 BAZ1A -0.51 -5.4 -0.31 1.49e-7 Psoriasis; CESC cis rs8062405 1.000 rs1987472 chr16:28825777 C/T cg08761264 chr16:28874980 SH2B1 -0.45 -5.7 -0.33 3.19e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1044826 0.642 rs407958 chr3:139213632 T/C cg00490450 chr3:139108681 COPB2 0.42 5.09 0.3 6.87e-7 Obesity-related traits; CESC cis rs13253111 0.583 rs6993376 chr8:28096300 A/C cg26534493 chr8:28060551 NA 0.48 7.52 0.42 8.73e-13 Childhood body mass index; CESC cis rs4746818 1.000 rs7893492 chr10:70960448 C/T cg11621586 chr10:70884670 VPS26A -0.8 -8.11 -0.45 1.9e-14 Left atrial antero-posterior diameter; CESC cis rs2857078 0.720 rs9901595 chr17:42305699 G/A cg08499158 chr17:42289980 UBTF -0.41 -5.1 -0.3 6.39e-7 Red cell distribution width;Reticulocyte count; CESC cis rs11264213 0.786 rs72659690 chr1:36291750 G/A cg27506609 chr1:36549197 TEKT2 0.61 5.04 0.3 8.54e-7 Schizophrenia; CESC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg17158414 chr2:27665306 KRTCAP3 -0.28 -5.12 -0.3 5.87e-7 Total body bone mineral density; CESC cis rs2204008 0.536 rs12368354 chr12:38042798 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.63 0.38 1.87e-10 Bladder cancer; CESC cis rs2644899 0.750 rs2249835 chr19:41269766 G/A cg24958765 chr19:41283667 RAB4B -0.57 -6.63 -0.38 1.93e-10 Post bronchodilator FEV1/FVC ratio; CESC cis rs858239 0.699 rs1881200 chr7:23201637 T/C cg23682824 chr7:23144976 KLHL7 -0.38 -5.14 -0.3 5.4e-7 Cerebrospinal fluid biomarker levels; CESC cis rs9902453 0.740 rs2628189 chr17:28088813 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.42 -0.54 1.51e-21 Coffee consumption (cups per day); CESC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg24829409 chr8:58192753 C8orf71 -0.72 -8.48 -0.46 1.65e-15 Developmental language disorder (linguistic errors); CESC cis rs11122272 0.735 rs2739509 chr1:231526765 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.69 -0.43 2.97e-13 Hemoglobin concentration; CESC trans rs11250098 0.574 rs4554431 chr8:10771638 T/A cg06636001 chr8:8085503 FLJ10661 -0.5 -6.23 -0.36 1.82e-9 Morning vs. evening chronotype; CESC cis rs4253772 0.591 rs9615343 chr22:46690824 C/G cg18190219 chr22:46762943 CELSR1 -0.59 -5.45 -0.32 1.14e-7 LDL cholesterol;Cholesterol, total; CESC cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg07507251 chr3:52567010 NT5DC2 -0.33 -5.54 -0.32 7.48e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs72781680 0.898 rs72788218 chr2:24090435 C/T cg20701182 chr2:24300061 SF3B14 0.59 5.44 0.32 1.23e-7 Lymphocyte counts; CESC cis rs2404602 0.735 rs3765115 chr15:76673716 T/C cg23625390 chr15:77176239 SCAPER -0.43 -5.93 -0.34 9.52e-9 Blood metabolite levels; CESC cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 7.22 0.41 5.52e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27109030 chr19:2702898 GNG7 0.43 6.14 0.35 3.05e-9 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs35391607 chr7:65360829 G/A cg13147721 chr7:65941812 NA -0.83 -7.97 -0.44 4.85e-14 Diabetic kidney disease; CESC cis rs9868809 0.772 rs9812200 chr3:48695667 A/G cg07636037 chr3:49044803 WDR6 0.59 5.24 0.31 3.34e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs7605827 0.930 rs9287661 chr2:15595901 G/A cg19274914 chr2:15703543 NA 0.33 5.97 0.34 7.72e-9 Educational attainment (years of education); CESC cis rs1707322 0.686 rs2152078 chr1:46055600 C/T cg05343316 chr1:45956843 TESK2 -0.53 -6.5 -0.37 3.87e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7551222 0.752 rs2369244 chr1:204515299 C/G cg20240347 chr1:204465584 NA 0.26 5.35 0.31 1.95e-7 Schizophrenia; CESC cis rs4642101 0.793 rs6763619 chr3:12822147 T/G cg05775895 chr3:12838266 CAND2 0.39 5.93 0.34 9.32e-9 QRS complex (12-leadsum); CESC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg04369109 chr6:150039330 LATS1 -0.39 -5.27 -0.31 2.82e-7 Lung cancer; CESC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.85 9.37 0.5 3.24e-18 Platelet count; CESC cis rs939574 0.790 rs72955452 chr2:220101783 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 7.33 0.41 2.86e-12 Platelet distribution width; CESC cis rs7772486 0.686 rs4895684 chr6:146114023 A/C cg05347473 chr6:146136440 FBXO30 -0.51 -6.72 -0.38 1.1e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -8.09 -0.44 2.23e-14 Developmental language disorder (linguistic errors); CESC cis rs2625529 0.730 rs4777485 chr15:72389384 G/C cg16672083 chr15:72433130 SENP8 -0.43 -6.09 -0.35 3.93e-9 Red blood cell count; CESC cis rs3820068 0.608 rs7552400 chr1:16035892 A/G cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.35 4.28e-9 Systolic blood pressure; CESC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg12648201 chr2:27665141 KRTCAP3 -0.3 -5.33 -0.31 2.13e-7 Total body bone mineral density; CESC cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg06636001 chr8:8085503 FLJ10661 0.41 5.28 0.31 2.74e-7 Mood instability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18033235 chr19:16989681 SIN3B -0.65 -7.49 -0.42 1.05e-12 Gut microbiome composition (summer); CESC cis rs71403859 0.614 rs12447033 chr16:71583655 G/T cg08717414 chr16:71523259 ZNF19 -0.83 -7.59 -0.42 5.57e-13 Post bronchodilator FEV1; CESC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg17971929 chr21:40555470 PSMG1 1.07 16.52 0.71 1.29e-42 Cognitive function; CESC cis rs13191362 0.935 rs13205279 chr6:162945030 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.68 5.9 0.34 1.1e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 11.37 0.57 1.16e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg04944784 chr2:26401820 FAM59B -0.94 -10.63 -0.55 3.14e-22 Gut microbiome composition (summer); CESC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg12373951 chr3:133503437 NA 0.43 6.3 0.36 1.24e-9 Iron status biomarkers; CESC cis rs748404 0.660 rs693510 chr15:43714625 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.37 0.46 3.47e-15 Lung cancer; CESC cis rs12477438 0.798 rs10198293 chr2:99602929 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs7219021 0.705 rs67174000 chr17:46982380 G/A cg16584676 chr17:46985605 UBE2Z -0.63 -7.84 -0.43 1.14e-13 Schizophrenia or bipolar disorder; CESC cis rs9911578 0.935 rs7218105 chr17:57041119 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.08 0.3 7.21e-7 Intelligence (multi-trait analysis); CESC cis rs7772486 0.790 rs2247429 chr6:146217769 T/C cg23711669 chr6:146136114 FBXO30 0.94 13.73 0.64 9.31e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg01416388 chr22:39784598 NA -0.59 -6.82 -0.39 6.08e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs4242434 0.927 rs57594397 chr8:22475657 T/C cg03733263 chr8:22462867 KIAA1967 0.94 12.79 0.62 1.7e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC trans rs9929218 0.953 rs3118227 chr16:68734855 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -9.55 -0.51 9.37e-19 Colorectal cancer; CESC trans rs931812 0.825 rs55818461 chr8:101899229 T/C cg20993868 chr7:22813445 NA 0.55 7.74 0.43 2.04e-13 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs1790761 0.692 rs1148883 chr11:67304686 A/G cg08355456 chr11:67383691 NA 0.34 5.32 0.31 2.2e-7 Mean corpuscular volume; CESC cis rs10791323 0.569 rs11223609 chr11:133741766 C/T cg15485101 chr11:133734466 NA 0.3 5.12 0.3 5.99e-7 Childhood ear infection; CESC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.36 -5.89 -0.34 1.2e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.57 5.61 0.33 4.98e-8 Cerebrospinal P-tau181p levels; CESC cis rs13255475 0.772 rs7824600 chr8:121506382 C/T cg05978010 chr8:121408224 MRPL13 -0.33 -5.12 -0.3 5.88e-7 Cerebrospinal T-tau levels;Cerebrospinal P-tau181p levels; CESC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.93e-7 Lung cancer; CESC cis rs11711311 0.712 rs3773683 chr3:113341007 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.54 7.09 0.4 1.24e-11 IgG glycosylation; CESC cis rs7923609 0.846 rs10761731 chr10:65027610 A/T cg01631684 chr10:65280961 REEP3 -0.44 -5.4 -0.31 1.51e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs11741688 0.557 rs10043579 chr5:178330174 C/T cg20935368 chr5:178288625 ZNF354B 0.34 5.4 0.32 1.45e-7 Sleep duration; CESC cis rs4243830 0.850 rs12029123 chr1:6607142 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.95 9.41 0.5 2.46e-18 Body mass index; CESC cis rs748404 0.631 rs12905772 chr15:43648444 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.42 0.46 2.44e-15 Lung cancer; CESC cis rs35110281 0.591 rs162390 chr21:44936826 C/T cg01579765 chr21:45077557 HSF2BP -0.48 -8.29 -0.45 5.8e-15 Mean corpuscular volume; CESC cis rs3096299 0.728 rs1011749 chr16:89510869 G/C cg08392591 chr16:89556376 ANKRD11 0.57 7.71 0.43 2.51e-13 Multiple myeloma (IgH translocation); CESC cis rs4689388 0.824 rs114669221 chr4:6301459 G/A cg00701064 chr4:6280414 WFS1 0.68 11.88 0.59 2.27e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs959260 1.000 rs4789189 chr17:73397985 C/G cg20590849 chr17:73267439 MIF4GD -0.57 -6.49 -0.37 4.3e-10 Systemic lupus erythematosus; CESC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg22800045 chr5:56110881 MAP3K1 -0.76 -8.63 -0.47 5.76e-16 Initial pursuit acceleration; CESC cis rs561341 1.000 rs473356 chr17:30321762 G/C cg00745463 chr17:30367425 LRRC37B -0.82 -7.51 -0.42 9.09e-13 Hip circumference adjusted for BMI; CESC cis rs10197940 0.710 rs4500942 chr2:152334580 A/G cg19508488 chr2:152266495 RIF1 0.49 5.82 0.34 1.68e-8 Lung cancer; CESC cis rs7845219 0.506 rs12548999 chr8:95929843 C/T cg16049864 chr8:95962084 TP53INP1 -0.46 -6.68 -0.38 1.43e-10 Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25449970 chr10:5550506 NA 0.44 6.19 0.36 2.26e-9 Fibrinogen levels; CESC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg15369054 chr17:80825471 TBCD 0.53 7.21 0.4 5.94e-12 Breast cancer; CESC cis rs11098499 0.863 rs2306457 chr4:120472839 T/A cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.02e-8 Corneal astigmatism; CESC cis rs12079745 0.793 rs3753298 chr1:169176899 G/A cg09363564 chr1:169337483 NME7;BLZF1 -1.1 -6.5 -0.37 3.95e-10 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23094080 chr8:145550361 DGAT1 0.54 6.29 0.36 1.34e-9 Gut microbiome composition (summer); CESC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg04282206 chr17:62833786 PLEKHM1P 0.55 6.41 0.37 6.71e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.84 0.34 1.55e-8 Tonsillectomy; CESC cis rs3126085 0.877 rs3126045 chr1:152256794 A/G cg03465714 chr1:152285911 FLG -0.45 -5.54 -0.32 7.12e-8 Atopic dermatitis; CESC cis rs6598955 0.671 rs12085416 chr1:26627835 T/C cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.45 0.32 1.18e-7 Obesity-related traits; CESC cis rs4843747 0.518 rs4072777 chr16:88107030 G/A cg06915872 chr16:87998081 BANP 0.44 5.24 0.31 3.36e-7 Menopause (age at onset); CESC cis rs9911578 1.000 rs437732 chr17:56675861 A/C cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC trans rs801193 1.000 rs6958520 chr7:66151453 T/C cg26939375 chr7:64535504 NA 0.64 8.81 0.48 1.69e-16 Aortic root size; CESC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg26516362 chr5:178986906 RUFY1 0.36 5.46 0.32 1.11e-7 Lung cancer; CESC cis rs1348850 0.793 rs6734528 chr2:178493731 G/A cg23306229 chr2:178417860 TTC30B 0.56 7.14 0.4 9.13e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3740713 1.000 rs1848048 chr11:18468996 T/C cg23797887 chr11:18477753 LDHAL6A -0.54 -5.21 -0.31 3.72e-7 Amyotrophic lateral sclerosis (sporadic); CESC trans rs7937682 1.000 rs505372 chr11:111507189 A/C cg18187862 chr3:45730750 SACM1L 0.48 6.04 0.35 5.1e-9 Primary sclerosing cholangitis; CESC cis rs6424115 0.830 rs6680132 chr1:24198804 T/C cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC cis rs7107174 1.000 rs2510041 chr11:77945284 G/A cg02023728 chr11:77925099 USP35 0.44 6.19 0.36 2.3e-9 Testicular germ cell tumor; CESC cis rs1801251 0.928 rs737028 chr2:233640750 T/C cg25237894 chr2:233734115 C2orf82 0.45 7.98 0.44 4.53e-14 Coronary artery disease; CESC cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg10523679 chr1:76189770 ACADM -0.7 -8.01 -0.44 3.6e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9488822 0.676 rs11153594 chr6:116354591 A/G cg18764771 chr6:116381957 FRK -0.24 -6.03 -0.35 5.58e-9 Cholesterol, total;LDL cholesterol; CESC cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg03433033 chr1:76189801 ACADM -0.62 -6.47 -0.37 4.68e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg17427002 chr7:12443146 VWDE -0.48 -5.42 -0.32 1.35e-7 Coronary artery disease; CESC cis rs763121 0.744 rs5757140 chr22:38957013 T/C cg14440974 chr22:39074834 NA -0.4 -5.25 -0.31 3.08e-7 Menopause (age at onset); CESC cis rs9611565 0.729 rs203319 chr22:41914593 C/T cg17376030 chr22:41985996 PMM1 0.48 5.71 0.33 3.04e-8 Vitiligo; CESC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg18904891 chr8:8559673 CLDN23 0.7 7.82 0.43 1.26e-13 Obesity-related traits; CESC cis rs56104184 0.775 rs73063505 chr19:49402765 T/C cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs9487051 0.676 rs6933326 chr6:109601333 C/T cg21918786 chr6:109611834 NA -0.39 -5.74 -0.33 2.65e-8 Reticulocyte fraction of red cells; CESC cis rs7923609 0.902 rs10822158 chr10:65094383 A/G cg01631684 chr10:65280961 REEP3 -0.42 -5.26 -0.31 3.04e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs9787249 0.957 rs12086750 chr1:40210468 G/C cg24920358 chr1:40204285 PPIE 0.42 6.37 0.36 8.16e-10 Blood protein levels; CESC cis rs4523957 0.614 rs7208638 chr17:2061334 G/C cg16513277 chr17:2031491 SMG6 -0.72 -10.2 -0.53 8.12e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11828289 0.660 rs28825707 chr11:23224075 G/A cg20040320 chr11:23191996 NA -0.7 -5.78 -0.33 2.11e-8 Cancer; CESC cis rs1018836 0.663 rs56784954 chr8:91505094 C/T cg16814680 chr8:91681699 NA -0.58 -7.68 -0.43 3e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.78 9.51 0.5 1.25e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs1670533 1.000 rs28562028 chr4:1055115 G/A cg04106633 chr4:1044584 NA 0.41 5.19 0.3 4.11e-7 Recombination rate (females); CESC cis rs2370759 1.000 rs2370759 chr10:32634972 G/A cg18270830 chr10:32634957 EPC1 0.71 6.87 0.39 4.58e-11 Sexual dysfunction (female); CESC cis rs7666738 0.606 rs28625338 chr4:99076996 A/G cg05340658 chr4:99064831 C4orf37 0.65 9.19 0.49 1.17e-17 Colonoscopy-negative controls vs population controls; CESC cis rs3820928 0.804 rs4144327 chr2:227790262 C/T cg05526886 chr2:227700861 RHBDD1 -0.4 -5.2 -0.3 3.93e-7 Pulmonary function; CESC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg11041457 chr3:52719354 GNL3;PBRM1 -0.5 -7.63 -0.42 4.19e-13 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02222454 chr3:141762828 NA 0.48 6.28 0.36 1.36e-9 Fibrinogen levels; CESC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.49 0.42 1.01e-12 Prudent dietary pattern; CESC cis rs589448 0.535 rs12423794 chr12:69713018 G/A cg22834771 chr12:69754056 YEATS4 -0.43 -5.5 -0.32 8.86e-8 Cerebrospinal fluid biomarker levels; CESC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg22968622 chr17:43663579 NA 0.8 9.85 0.52 1.06e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7503807 0.967 rs9915162 chr17:78614326 T/C cg09596252 chr17:78655493 RPTOR 0.52 7.73 0.43 2.3e-13 Obesity; CESC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.67 -0.33 3.77e-8 Total body bone mineral density; CESC cis rs2463822 0.583 rs72919477 chr11:62042403 G/C cg06239285 chr11:62104954 ASRGL1 -1.09 -8.77 -0.47 2.15e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs4919694 1.000 rs12257935 chr10:104803062 C/A cg04362960 chr10:104952993 NT5C2 0.79 7.08 0.4 1.27e-11 Arsenic metabolism; CESC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.87 0.39 4.46e-11 Platelet count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22146484 chr8:57123862 CHCHD7;PLAG1 0.48 6.15 0.35 2.8e-9 Gut microbiota (bacterial taxa); CESC trans rs61931739 0.500 rs7307583 chr12:34521711 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.55 0.42 7.05e-13 Morning vs. evening chronotype; CESC cis rs11122272 0.735 rs2808611 chr1:231548480 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.52 6.98 0.39 2.42e-11 Hemoglobin concentration; CESC cis rs6429082 0.811 rs291348 chr1:235667690 A/G cg26050004 chr1:235667680 B3GALNT2 0.83 12.89 0.62 7.78e-30 Adiposity; CESC cis rs9303280 0.901 rs7359623 chr17:38049589 C/T cg20243544 chr17:37824526 PNMT 0.5 6.5 0.37 3.94e-10 Self-reported allergy; CESC trans rs13401620 0.843 rs3101945 chr2:120591657 A/G cg01115923 chr16:57793728 KIFC3 0.33 6.05 0.35 5e-9 Breast size; CESC cis rs853679 1.000 rs7740487 chr6:28216486 C/G cg12740337 chr6:28058973 ZSCAN12L1 0.32 5.06 0.3 7.74e-7 Depression; CESC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg21361702 chr7:150065534 REPIN1 0.49 5.39 0.31 1.54e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg07701084 chr6:150067640 NUP43 0.43 5.86 0.34 1.4e-8 Lung cancer; CESC cis rs1348850 0.668 rs4893971 chr2:178495743 T/C cg22681709 chr2:178499509 PDE11A -0.41 -5.9 -0.34 1.09e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11098499 0.863 rs2306457 chr4:120472839 T/A cg25214090 chr10:38739885 LOC399744 0.65 8.96 0.48 5.89e-17 Corneal astigmatism; CESC cis rs3087591 0.959 rs9893872 chr17:29571195 G/A cg24425628 chr17:29625626 OMG;NF1 -0.45 -5.63 -0.33 4.56e-8 Hip circumference; CESC cis rs6582630 0.555 rs7133706 chr12:38475465 G/A cg13010199 chr12:38710504 ALG10B -0.43 -5.5 -0.32 9.15e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg13393036 chr8:95962371 TP53INP1 0.48 8.25 0.45 7.5e-15 Type 2 diabetes; CESC cis rs7520050 0.966 rs10890354 chr1:46305347 G/A cg03146154 chr1:46216737 IPP -0.48 -6.24 -0.36 1.68e-9 Red blood cell count;Reticulocyte count; CESC cis rs7301826 0.651 rs4514465 chr12:131313669 T/A cg11011512 chr12:131303247 STX2 0.45 5.58 0.32 5.98e-8 Plasma plasminogen activator levels; CESC cis rs55794721 0.509 rs2982358 chr1:25745204 G/T cg27572855 chr1:25598939 RHD 0.44 7.3 0.41 3.32e-12 Plateletcrit;Mean corpuscular volume; CESC cis rs753778 0.570 rs6985866 chr8:142210336 C/T cg18755752 chr8:142205143 DENND3 0.51 7.4 0.41 1.82e-12 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs9850225 0.719 rs4856616 chr3:80466481 A/C cg03650674 chr8:102505986 GRHL2 -0.35 -6.13 -0.35 3.26e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs4243830 0.826 rs12565181 chr1:6620545 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.94 9.09 0.49 2.34e-17 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01830674 chr2:219433148 RQCD1;USP37 -0.48 -6.63 -0.38 1.86e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs3087243 0.755 rs231792 chr2:204702249 A/G cg01841312 chr10:38069945 NA 0.39 6.38 0.36 7.83e-10 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC trans rs11098499 0.954 rs10008392 chr4:120318839 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.55 0.51 9.27e-19 Corneal astigmatism; CESC cis rs1153858 1.000 rs4775937 chr15:45678614 C/A cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs2115536 0.692 rs8036559 chr15:80170563 C/T cg00225070 chr15:80189496 MTHFS 0.41 5.45 0.32 1.15e-7 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg19193384 chr17:30244184 NA -0.67 -6.96 -0.39 2.6e-11 Hip circumference adjusted for BMI; CESC cis rs34779708 0.966 rs4934725 chr10:35398236 T/C cg04310649 chr10:35416472 CREM -0.52 -6.25 -0.36 1.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9287719 0.967 rs7600587 chr2:10739851 A/G cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs782590 0.935 rs782568 chr2:55881538 T/C cg18811423 chr2:55921094 PNPT1 0.78 12.63 0.61 6.09e-29 Metabolic syndrome; CESC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs7474896 0.583 rs10827817 chr10:37997974 A/G cg25427524 chr10:38739819 LOC399744 -0.44 -5.05 -0.3 8.37e-7 Obesity (extreme); CESC cis rs2228479 0.557 rs62056064 chr16:89903843 G/A cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC trans rs9467711 0.675 rs58825580 chr6:26365679 T/G cg06606381 chr12:133084897 FBRSL1 -0.68 -6.26 -0.36 1.5e-9 Autism spectrum disorder or schizophrenia; CESC cis rs10461617 0.541 rs7715822 chr5:56043600 G/T cg24531977 chr5:56204891 C5orf35 -0.72 -6.67 -0.38 1.44e-10 Type 2 diabetes; CESC cis rs2204008 0.811 rs2139752 chr12:38370398 C/T cg26384229 chr12:38710491 ALG10B 0.73 11.2 0.57 4.34e-24 Bladder cancer; CESC cis rs7598759 0.712 rs10933372 chr2:232332325 G/A cg19187155 chr2:232395269 NMUR1 0.39 6.12 0.35 3.36e-9 Noise-induced hearing loss; CESC cis rs5769765 0.954 rs5770739 chr22:50268014 C/G cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs8114671 0.967 rs6058202 chr20:33777983 A/G cg24642439 chr20:33292090 TP53INP2 0.42 5.04 0.3 8.77e-7 Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg27123106 chr10:855660 LARP4B -0.54 -6.87 -0.39 4.51e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6545883 0.965 rs1562308 chr2:61768421 A/C cg15711740 chr2:61764176 XPO1 -0.44 -5.34 -0.31 1.98e-7 Tuberculosis; CESC cis rs1577917 0.771 rs2484355 chr6:86394403 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.54 -7.72 -0.43 2.33e-13 Response to antipsychotic treatment; CESC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.39e-20 Developmental language disorder (linguistic errors); CESC cis rs10754283 0.967 rs4658302 chr1:90103336 A/G cg21401794 chr1:90099060 LRRC8C 0.7 9.42 0.5 2.27e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7647973 0.600 rs35174559 chr3:49287759 T/C cg03060546 chr3:49711283 APEH 0.51 6.99 0.39 2.25e-11 Menarche (age at onset); CESC cis rs1355223 0.872 rs12785367 chr11:34715269 G/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.43 -0.37 6.04e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7044106 0.791 rs10984995 chr9:123479210 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.21 0.53 7.21e-21 Hip circumference adjusted for BMI; CESC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg18252515 chr7:66147081 NA 0.39 5.08 0.3 7.05e-7 Aortic root size; CESC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs6570726 0.935 rs447247 chr6:145812678 G/T cg05347473 chr6:146136440 FBXO30 0.49 6.49 0.37 4.31e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2204008 0.777 rs6582664 chr12:37947022 A/G cg26384229 chr12:38710491 ALG10B -0.53 -7.59 -0.42 5.46e-13 Bladder cancer; CESC cis rs2230307 0.536 rs7518943 chr1:100463422 G/T cg24955406 chr1:100503596 HIAT1 0.52 5.15 0.3 5.2e-7 Carotid intima media thickness; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07596845 chr6:82957841 IBTK 0.48 6.36 0.36 8.58e-10 Gut microbiota (bacterial taxa); CESC cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg02079420 chr8:82753780 SNX16 0.5 7.56 0.42 6.82e-13 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11439475 chr15:52821378 MYO5A 0.53 6.08 0.35 4.26e-9 Gut microbiome composition (summer); CESC cis rs225245 0.791 rs7216391 chr17:34024706 G/A cg05299278 chr17:33885742 SLFN14 0.38 5.51 0.32 8.62e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs9902453 0.740 rs2254414 chr17:28061130 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.75 -9.91 -0.52 6.74e-20 Coffee consumption (cups per day); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15649193 chr19:14640403 TECR;MIR639 -0.43 -6.22 -0.36 1.92e-9 Fibrinogen levels; CESC cis rs7560272 0.723 rs12995433 chr2:73641326 C/T cg20560298 chr2:73613845 ALMS1 0.5 7.17 0.4 7.57e-12 Schizophrenia; CESC cis rs2276314 1.000 rs2276314 chr18:33557466 C/T cg05985134 chr18:33552581 C18orf21 -0.66 -7.95 -0.44 5.32e-14 Endometriosis;Drug-induced torsades de pointes; CESC cis rs72781680 0.898 rs56179550 chr2:23934867 C/T cg20701182 chr2:24300061 SF3B14 0.78 6.91 0.39 3.5e-11 Lymphocyte counts; CESC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg11644478 chr21:40555479 PSMG1 0.53 7.27 0.41 4.04e-12 Menarche (age at onset); CESC cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg03433033 chr1:76189801 ACADM 0.67 7.96 0.44 5.11e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4474465 0.915 rs12272791 chr11:78159426 G/A cg02023728 chr11:77925099 USP35 0.39 5.04 0.3 8.78e-7 Alzheimer's disease (survival time); CESC cis rs11718455 1.000 rs17076273 chr3:44020113 A/G cg08738300 chr3:44038990 NA 0.48 6.1 0.35 3.81e-9 Coronary artery disease; CESC cis rs3766606 0.505 rs60057745 chr1:7946819 G/A cg00042356 chr1:8021962 PARK7 0.57 5.22 0.31 3.56e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24434368 chr7:116593263 ST7;ST7OT4;ST7OT1 -0.44 -6.19 -0.36 2.31e-9 Asthma; CESC cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg16447950 chr5:562315 NA -0.62 -6.52 -0.37 3.51e-10 Lung disease severity in cystic fibrosis; CESC cis rs34638657 0.833 rs4889479 chr16:82201474 T/C cg09439754 chr16:82129088 HSD17B2 -0.34 -5.62 -0.33 4.8e-8 Lung adenocarcinoma; CESC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg11890956 chr21:40555474 PSMG1 -0.63 -8.76 -0.47 2.33e-16 Menarche (age at onset); CESC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.26 0.36 1.51e-9 Cystic fibrosis severity; CESC cis rs1707322 1.000 rs946524 chr1:46487560 A/G cg05343316 chr1:45956843 TESK2 -0.45 -5.54 -0.32 7.32e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1538970 0.924 rs1826691 chr1:45881262 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.52 -0.32 8.23e-8 Platelet count; CESC cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg00800038 chr16:89945340 TCF25 -0.69 -6.65 -0.38 1.66e-10 Skin colour saturation; CESC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg18402987 chr7:1209562 NA 0.76 7.55 0.42 7.26e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2769264 0.602 rs11204777 chr1:151072049 G/A cg11822372 chr1:151115635 SEMA6C 0.51 6.14 0.35 3.07e-9 Blood trace element (Cu levels); CESC cis rs9596863 0.847 rs9316667 chr13:54399759 C/T ch.13.53330881F chr13:54432880 NA 0.66 5.28 0.31 2.7e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC trans rs7726839 0.794 rs6883536 chr5:599274 G/A cg25482853 chr8:67687455 SGK3 0.62 6.36 0.36 8.59e-10 Obesity-related traits; CESC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg17949981 chr6:28129498 ZNF389 0.42 5.24 0.31 3.27e-7 Depression; CESC cis rs6963495 0.818 rs56165465 chr7:105180384 C/T cg13798780 chr7:105162888 PUS7 0.75 8.34 0.46 4.18e-15 Bipolar disorder (body mass index interaction); CESC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg20887711 chr4:1340912 KIAA1530 -0.62 -8.34 -0.46 4.1e-15 Obesity-related traits; CESC trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.56 7.84 0.43 1.07e-13 Intelligence (multi-trait analysis); CESC cis rs863345 0.564 rs7515245 chr1:158494110 A/G cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.75e-11 Pneumococcal bacteremia; CESC trans rs116095464 0.558 rs6881920 chr5:222411 T/C cg00938859 chr5:1591904 SDHAP3 0.6 6.66 0.38 1.55e-10 Breast cancer; CESC cis rs7100689 0.577 rs756208 chr10:82041751 A/G cg00277334 chr10:82204260 NA -0.54 -7.05 -0.4 1.53e-11 Post bronchodilator FEV1; CESC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1594829 0.553 rs11135933 chr8:26162364 A/G cg11498726 chr8:26250323 BNIP3L -0.4 -6.06 -0.35 4.68e-9 Height; CESC cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg02551604 chr5:131831745 NA -0.35 -5.1 -0.3 6.59e-7 Asthma (sex interaction); CESC cis rs7635838 0.785 rs2594972 chr3:11397417 A/G cg00170343 chr3:11313890 ATG7 0.44 6.27 0.36 1.43e-9 HDL cholesterol; CESC cis rs6582630 0.555 rs34730221 chr12:38405140 C/T cg13010199 chr12:38710504 ALG10B -0.45 -5.79 -0.34 2e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs71403859 0.730 rs12446333 chr16:71752157 T/C cg08717414 chr16:71523259 ZNF19 -0.68 -5.42 -0.32 1.37e-7 Post bronchodilator FEV1; CESC cis rs2404602 0.669 rs12595313 chr15:76978370 A/G cg22467129 chr15:76604101 ETFA -0.34 -5.15 -0.3 5.13e-7 Blood metabolite levels; CESC cis rs5769707 0.749 rs7286706 chr22:50058346 G/C cg20744362 chr22:50050164 C22orf34 0.41 7.16 0.4 8.13e-12 Monocyte count;Monocyte percentage of white cells; CESC cis rs478304 0.903 rs1151502 chr11:65503485 G/C cg08755490 chr11:65554678 OVOL1 0.47 6.21 0.36 2.06e-9 Acne (severe); CESC cis rs1270639 0.778 rs2952650 chr7:157450939 C/T cg13357408 chr7:157437802 PTPRN2 0.62 6.81 0.39 6.37e-11 Colorectal cancer; CESC cis rs7264396 0.563 rs6060569 chr20:34290731 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.86 0.39 4.8e-11 Total cholesterol levels; CESC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.21e-8 Lung cancer; CESC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.41 -0.32 1.39e-7 Developmental language disorder (linguistic errors); CESC cis rs826838 0.933 rs980573 chr12:39127811 T/C cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs8020095 0.571 rs1955606 chr14:67477647 A/G cg19548862 chr14:67692701 FAM71D -0.49 -6.09 -0.35 3.92e-9 Depression (quantitative trait); CESC cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg12386194 chr3:101231763 SENP7 0.62 6.69 0.38 1.3100000000000001e-10 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg08859206 chr1:53392774 SCP2 -0.57 -7.77 -0.43 1.78e-13 Monocyte count; CESC cis rs28489187 0.706 rs761601 chr1:85797298 A/G cg16011679 chr1:85725395 C1orf52 0.56 6.48 0.37 4.45e-10 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs73206853 0.841 rs3026483 chr12:110780905 A/G cg12870014 chr12:110450643 ANKRD13A 0.66 5.42 0.32 1.36e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg17372223 chr3:52568218 NT5DC2 -0.36 -5.16 -0.3 4.95e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs9291683 0.609 rs4622999 chr4:10003395 C/G cg00071950 chr4:10020882 SLC2A9 0.83 14.91 0.68 6.47e-37 Bone mineral density; CESC cis rs6835098 0.924 rs7672108 chr4:174165126 A/G cg08422745 chr4:174089978 GALNT7 0.73 10.76 0.55 1.26e-22 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs62005083 1.000 rs62005115 chr14:74528952 G/C cg05179529 chr14:74551516 LIN52;ALDH6A1 0.62 5.07 0.3 7.61e-7 Mean corpuscular volume; CESC cis rs17539620 0.624 rs62432738 chr6:154835674 T/C cg20019720 chr6:154832845 CNKSR3 0.46 6.13 0.35 3.22e-9 Lipoprotein (a) levels; CESC cis rs3126085 0.935 rs4845421 chr1:152173259 G/T cg26876637 chr1:152193138 HRNR 0.45 5.11 0.3 6.05e-7 Atopic dermatitis; CESC cis rs8017423 0.967 rs4900033 chr14:90701963 C/A cg14092571 chr14:90743983 NA -0.57 -8.35 -0.46 3.87e-15 Mortality in heart failure; CESC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -5.72 -0.33 2.85e-8 Extrinsic epigenetic age acceleration; CESC cis rs7208859 0.623 rs216434 chr17:28922335 G/C cg13385521 chr17:29058706 SUZ12P 0.75 5.52 0.32 7.98e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg02951883 chr7:2050386 MAD1L1 -0.46 -6.0 -0.35 6.38e-9 Bipolar disorder and schizophrenia; CESC cis rs2180341 0.814 rs6914131 chr6:127737489 T/C cg27446573 chr6:127587934 RNF146 0.82 11.65 0.58 1.38e-25 Breast cancer; CESC cis rs8062405 0.721 rs151181 chr16:28490517 A/G cg08761264 chr16:28874980 SH2B1 -0.45 -5.44 -0.32 1.23e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4834770 1.000 rs4834771 chr4:120242772 C/A cg09307838 chr4:120376055 NA 0.45 5.37 0.31 1.74e-7 Blood protein levels; CESC cis rs2625529 0.730 rs6494990 chr15:72401074 T/A cg16672083 chr15:72433130 SENP8 0.44 6.72 0.38 1.09e-10 Red blood cell count; CESC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg24549020 chr5:56110836 MAP3K1 -0.51 -6.31 -0.36 1.18e-9 Initial pursuit acceleration; CESC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg10691866 chr7:65817282 TPST1 -0.31 -5.16 -0.3 4.78e-7 Aortic root size; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05124756 chr4:2263820 MXD4 0.44 6.03 0.35 5.56e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7520050 0.966 rs785492 chr1:46583607 G/A cg03146154 chr1:46216737 IPP -0.43 -5.52 -0.32 8.2e-8 Red blood cell count;Reticulocyte count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14431266 chr11:67057003 ANKRD13D 0.5 6.67 0.38 1.5e-10 Gut microbiota (bacterial taxa); CESC cis rs1729951 0.575 rs361243 chr3:136697786 C/T cg15507776 chr3:136538369 TMEM22 0.4 5.06 0.3 8.02e-7 Neuroticism; CESC cis rs6504249 0.893 rs2521827 chr17:62692728 T/G cg02097616 chr17:62675921 NA 0.42 5.1 0.3 6.39e-7 Joint mobility (Beighton score); CESC trans rs3936060 0.551 rs6872503 chr5:124374180 A/G cg23072383 chr22:31031044 SLC35E4 -0.39 -6.22 -0.36 1.89e-9 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26574964 chr11:117049906 SIDT2 -0.5 -6.46 -0.37 5.12e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3087591 1.000 rs2905877 chr17:29543269 A/C cg24425628 chr17:29625626 OMG;NF1 -0.43 -5.22 -0.31 3.57e-7 Hip circumference; CESC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg02269571 chr22:50332266 NA -0.57 -6.98 -0.39 2.33e-11 Schizophrenia; CESC cis rs733175 0.855 rs6853437 chr4:10005435 A/G cg00071950 chr4:10020882 SLC2A9 -0.56 -6.74 -0.38 9.61e-11 Psychosis and Alzheimer's disease; CESC cis rs7833986 0.501 rs2953898 chr8:56980803 C/T cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.16 0.3 4.9e-7 Height; CESC cis rs2249625 0.874 rs1852704 chr6:72880088 C/T cg18830697 chr6:72922368 RIMS1 -0.39 -5.53 -0.32 7.83e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.01 11.77 0.59 5.45e-26 Platelet count; CESC cis rs9790314 0.875 rs336568 chr3:161072763 G/C cg03342759 chr3:160939853 NMD3 -0.42 -5.75 -0.33 2.43e-8 Morning vs. evening chronotype; CESC cis rs10911363 0.592 rs2702180 chr1:183517971 T/C cg09173681 chr1:183549694 NCF2 0.53 8.02 0.44 3.49e-14 Systemic lupus erythematosus; CESC cis rs4604732 0.642 rs10925048 chr1:247640736 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.45 6.54 0.37 3.08e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7243790 0.846 rs56053948 chr18:51960665 C/A cg04730925 chr18:51795821 POLI -0.42 -5.54 -0.32 7.14e-8 Diastolic blood pressure; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08162257 chr15:90777190 CIB1;C15orf58 -0.49 -6.1 -0.35 3.74e-9 Ulcerative colitis; CESC cis rs11583043 1.000 rs7541397 chr1:101322866 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.46 -5.37 -0.31 1.73e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs2841277 0.676 rs4264326 chr14:105411700 A/G cg21017887 chr14:105400489 NA 0.41 6.6 0.38 2.17e-10 Rheumatoid arthritis; CESC cis rs6912958 0.712 rs4706294 chr6:88317675 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.25 -0.31 3.18e-7 Monocyte percentage of white cells; CESC cis rs4919087 0.962 rs3814164 chr10:98982749 G/A cg25902810 chr10:99078978 FRAT1 0.71 10.32 0.54 3.25e-21 Monocyte count; CESC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg22590775 chr19:49891494 CCDC155 0.54 6.45 0.37 5.19e-10 Multiple sclerosis; CESC cis rs6500395 1.000 rs11647048 chr16:48623227 T/G cg04672837 chr16:48644449 N4BP1 0.47 5.82 0.34 1.72e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs854765 0.654 rs11078400 chr17:17757728 A/G cg04398451 chr17:18023971 MYO15A 0.67 10.08 0.53 1.98e-20 Total body bone mineral density; CESC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg21724239 chr8:58056113 NA 0.59 5.24 0.31 3.36e-7 Developmental language disorder (linguistic errors); CESC cis rs7202877 0.610 rs4536500 chr16:75343197 C/G cg04384234 chr16:75411784 CFDP1 0.43 5.16 0.3 4.75e-7 Type 2 diabetes;Type 1 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06999776 chr2:74881146 SEMA4F -0.55 -6.46 -0.37 4.99e-10 Gut microbiome composition (summer); CESC cis rs2806561 0.765 rs2806557 chr1:23503372 T/A cg12483005 chr1:23474871 LUZP1 0.39 6.18 0.36 2.37e-9 Height; CESC cis rs4849845 0.886 rs13412677 chr2:121029517 C/G cg24070213 chr2:121070622 NA 0.39 5.04 0.3 8.71e-7 Mean platelet volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10557320 chr6:12012551 HIVEP1 0.42 6.03 0.35 5.62e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7937682 0.564 rs1944116 chr11:111366792 A/C cg09085632 chr11:111637200 PPP2R1B 0.47 5.46 0.32 1.1e-7 Primary sclerosing cholangitis; CESC trans rs7618501 1.000 rs11716575 chr3:49744890 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.44 -0.46 2.11e-15 Intelligence (multi-trait analysis); CESC cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.77 8.79 0.48 1.96e-16 Alzheimer's disease; CESC cis rs853679 0.882 rs9380069 chr6:28203300 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.68 6.32 0.36 1.08e-9 Depression; CESC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.63 0.38 1.86e-10 Intelligence (multi-trait analysis); CESC cis rs11785400 0.793 rs6996760 chr8:143722386 G/A cg24634471 chr8:143751801 JRK 0.43 5.57 0.32 6.39e-8 Schizophrenia; CESC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg23758822 chr17:41437982 NA -1.02 -17.99 -0.74 7.99e-48 Menopause (age at onset); CESC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg00908189 chr16:619842 PIGQ 0.61 8.38 0.46 3.17e-15 Height; CESC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg17724175 chr1:150552817 MCL1 0.43 7.02 0.4 1.87e-11 Tonsillectomy; CESC cis rs6460942 1.000 rs2053382 chr7:12400587 A/G cg20607287 chr7:12443886 VWDE -0.67 -7.69 -0.43 2.8e-13 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05919122 chr15:20104494 NA -0.51 -6.47 -0.37 4.7e-10 Gut microbiome composition (summer); CESC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.45 -0.37 5.42e-10 Total body bone mineral density; CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg18765753 chr7:1198926 ZFAND2A -0.5 -7.38 -0.41 2.04e-12 Longevity;Endometriosis; CESC cis rs7100689 0.577 rs10749551 chr10:82054001 A/C cg00277334 chr10:82204260 NA -0.53 -6.92 -0.39 3.3e-11 Post bronchodilator FEV1; CESC cis rs7312774 0.881 rs60941459 chr12:107318583 T/C cg16260113 chr12:107380972 MTERFD3 0.68 6.37 0.36 8.12e-10 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00214056 chr18:46478384 SMAD7 0.69 8.29 0.45 5.89e-15 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04524321 chr12:57916344 MBD6 0.58 6.38 0.36 7.7e-10 Gut microbiome composition (summer); CESC cis rs60843830 1.000 rs55946380 chr2:268293 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.88 11.83 0.59 3.33e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs28374715 0.532 rs28703570 chr15:41679492 G/A cg20272979 chr15:41787780 ITPKA 0.41 5.05 0.3 8.42e-7 Ulcerative colitis; CESC cis rs6460942 0.908 rs73301032 chr7:12256799 C/G cg20607287 chr7:12443886 VWDE -0.55 -5.69 -0.33 3.34e-8 Coronary artery disease; CESC cis rs1153858 1.000 rs4774577 chr15:45644685 A/C cg21132104 chr15:45694354 SPATA5L1 0.84 11.4 0.57 9.5e-25 Homoarginine levels; CESC cis rs684232 0.805 rs2360737 chr17:506163 C/T cg15660573 chr17:549704 VPS53 -0.42 -5.63 -0.33 4.65e-8 Prostate cancer; CESC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg17372223 chr3:52568218 NT5DC2 0.43 6.5 0.37 4.04e-10 Bipolar disorder; CESC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg22920501 chr2:26401640 FAM59B -0.91 -10.33 -0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs4233802 1.000 rs4425095 chr2:151139757 C/T cg25300694 chr2:151184358 NA 0.88 7.6 0.42 5.07e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC trans rs5756813 0.688 rs34891095 chr22:38126582 C/T cg19894588 chr14:64061835 NA -0.65 -7.41 -0.41 1.7e-12 Optic cup area;Vertical cup-disc ratio; CESC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7618501 0.699 rs9821675 chr3:49902544 A/G cg24110177 chr3:50126178 RBM5 -0.45 -5.95 -0.34 8.26e-9 Intelligence (multi-trait analysis); CESC cis rs9393777 0.623 rs9358945 chr6:26472114 C/T cg14345882 chr6:26364793 BTN3A2 -0.41 -5.07 -0.3 7.46e-7 Intelligence (multi-trait analysis); CESC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg17971929 chr21:40555470 PSMG1 0.98 13.06 0.63 2.04e-30 Cognitive function; CESC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg18876405 chr7:65276391 NA -0.59 -7.9 -0.44 7.25e-14 Aortic root size; CESC cis rs1707322 1.000 rs1768818 chr1:46514286 G/C cg03146154 chr1:46216737 IPP -0.72 -9.73 -0.51 2.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11636714 chr8:42128950 IKBKB 0.6 7.23 0.41 5.33e-12 Gut microbiome composition (summer); CESC cis rs10779751 0.734 rs7533211 chr1:11132965 G/C cg08854313 chr1:11322531 MTOR 0.79 11.17 0.57 5.4e-24 Body mass index; CESC cis rs2243480 1.000 rs36068983 chr7:65408991 C/T cg13147721 chr7:65941812 NA -0.85 -8.1 -0.45 2e-14 Diabetic kidney disease; CESC cis rs9929218 0.953 rs12930910 chr16:68762520 A/G cg02972257 chr16:68554789 NA 0.55 6.37 0.36 8.53e-10 Colorectal cancer; CESC cis rs6964587 0.934 rs12531561 chr7:91707780 A/G cg17063962 chr7:91808500 NA 0.59 8.09 0.45 2.1e-14 Breast cancer; CESC cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg00033643 chr7:134001901 SLC35B4 0.4 5.14 0.3 5.46e-7 Mean platelet volume; CESC cis rs1878931 0.545 rs28603 chr16:3449479 A/G cg05754148 chr16:3507555 NAT15 0.44 5.22 0.31 3.63e-7 Body mass index (adult); CESC cis rs4692589 0.540 rs1904823 chr4:170956772 C/T cg19918862 chr4:170955249 NA 0.42 5.43 0.32 1.26e-7 Anxiety disorder; CESC cis rs643506 0.874 rs687152 chr11:111721673 T/C cg09085632 chr11:111637200 PPP2R1B 0.4 5.21 0.31 3.71e-7 Breast cancer; CESC cis rs1538970 0.810 rs12067642 chr1:45927517 G/T cg24296786 chr1:45957014 TESK2 -0.44 -5.18 -0.3 4.5e-7 Platelet count; CESC cis rs17384381 0.861 rs2300640 chr1:85823795 C/G cg16011679 chr1:85725395 C1orf52 0.8 8.18 0.45 1.16e-14 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10509185 chr10:134504666 INPP5A 0.51 6.73 0.38 1.06e-10 Fibrinogen levels; CESC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg20933634 chr6:27740509 NA 0.4 5.45 0.32 1.18e-7 Parkinson's disease; CESC cis rs9388451 0.536 rs34725880 chr6:126155237 A/G cg05901451 chr6:126070800 HEY2 -0.43 -5.87 -0.34 1.33e-8 Brugada syndrome; CESC cis rs4727027 0.933 rs12667123 chr7:148850621 G/A cg23583168 chr7:148888333 NA -0.81 -12.69 -0.61 3.68e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3741404 0.609 rs592271 chr11:63872029 G/T cg18225595 chr11:63971243 STIP1 0.5 6.59 0.38 2.39e-10 Platelet count; CESC cis rs7845219 0.544 rs4735331 chr8:95917958 C/T cg09323728 chr8:95962352 TP53INP1 -0.34 -6.59 -0.38 2.41e-10 Type 2 diabetes; CESC cis rs4474465 0.790 rs10899554 chr11:78265667 T/G cg27205649 chr11:78285834 NARS2 0.45 5.57 0.32 6.11e-8 Alzheimer's disease (survival time); CESC cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg10523679 chr1:76189770 ACADM -0.68 -7.79 -0.43 1.56e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7605827 0.930 rs2111453 chr2:15673248 C/T cg19274914 chr2:15703543 NA 0.38 6.8 0.39 7.12e-11 Educational attainment (years of education); CESC cis rs763121 0.925 rs4821797 chr22:39016182 T/C cg21395723 chr22:39101663 GTPBP1 0.46 5.97 0.34 7.61e-9 Menopause (age at onset); CESC cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg12292205 chr6:26970375 C6orf41 -0.5 -5.67 -0.33 3.8e-8 Intelligence (multi-trait analysis); CESC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg27121462 chr16:89883253 FANCA 0.75 10.57 0.54 5.18e-22 Vitiligo; CESC cis rs1707322 0.963 rs4630155 chr1:46257110 G/C cg03146154 chr1:46216737 IPP 0.8 11.02 0.56 1.72e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs939658 0.805 rs939661 chr15:79431063 A/G cg17916960 chr15:79447300 NA -0.38 -6.18 -0.35 2.43e-9 Refractive error; CESC cis rs2243480 0.901 rs13237344 chr7:66022256 T/A cg18252515 chr7:66147081 NA -1.4 -14.27 -0.66 1.16e-34 Diabetic kidney disease; CESC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.93 0.34 9.63e-9 Tonsillectomy; CESC cis rs11958404 0.615 rs6884132 chr5:157437035 G/A cg05962755 chr5:157440814 NA 0.42 6.13 0.35 3.1e-9 IgG glycosylation; CESC cis rs11718455 0.960 rs13059547 chr3:44004492 G/A cg08738300 chr3:44038990 NA 0.46 6.12 0.35 3.34e-9 Coronary artery disease; CESC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.43 -0.37 5.89e-10 Electroencephalogram traits; CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22466171 chr4:99850251 EIF4E -0.45 -5.12 -0.3 6.01e-7 Gut microbiome composition (summer); CESC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg03709012 chr19:19516395 GATAD2A 1.01 15.7 0.69 1.02e-39 Tonsillectomy; CESC trans rs4950322 0.515 rs72691016 chr1:146717027 T/C cg04954894 chr8:38089920 DDHD2 -0.55 -6.07 -0.35 4.3e-9 Protein quantitative trait loci; CESC cis rs7666738 0.830 rs11725477 chr4:98803266 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.43 0.32 1.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs6879656 chr5:264428 T/C cg22496380 chr5:211416 CCDC127 -0.85 -9.0 -0.48 4.59e-17 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10658516 chr2:98612531 TMEM131 0.59 6.58 0.37 2.53e-10 Gut microbiome composition (summer); CESC cis rs9929218 1.000 rs12596061 chr16:68807828 A/G cg02972257 chr16:68554789 NA 0.48 5.73 0.33 2.71e-8 Colorectal cancer; CESC cis rs9905704 0.723 rs71372848 chr17:56736598 G/C cg12560992 chr17:57184187 TRIM37 0.59 6.95 0.39 2.9e-11 Testicular germ cell tumor; CESC cis rs6089829 0.888 rs4809468 chr20:61673566 T/C cg16240275 chr20:61666158 NCRNA00029 0.49 8.3 0.45 5.23e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg11764359 chr7:65958608 NA 0.98 15.78 0.7 5.36e-40 Aortic root size; CESC cis rs7772486 0.738 rs75288066 chr6:146319386 C/A cg05347473 chr6:146136440 FBXO30 0.5 6.47 0.37 4.8e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs11098499 0.909 rs28884220 chr4:120307211 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs8060686 0.623 rs6499162 chr16:68239460 T/C cg26727032 chr16:67993705 SLC12A4 -0.59 -8.17 -0.45 1.3e-14 HDL cholesterol;Metabolic syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26561082 chr10:410363 DIP2C -0.65 -7.28 -0.41 3.83e-12 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14761318 chr5:68788469 OCLN 0.56 6.56 0.37 2.75e-10 Gut microbiome composition (summer); CESC cis rs9596863 0.756 rs9316652 chr13:54279802 T/C ch.13.53330881F chr13:54432880 NA 0.62 5.08 0.3 6.99e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23987549 chr20:56285728 PMEPA1 0.39 6.25 0.36 1.64e-9 Gambling; CESC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.99 16.42 0.71 2.9e-42 Height; CESC cis rs818427 0.896 rs430665 chr5:112228667 G/A cg07820702 chr5:112228657 REEP5 -0.41 -5.15 -0.3 4.99e-7 Total body bone mineral density; CESC cis rs3126085 0.935 rs10888466 chr1:152166223 A/C cg26876637 chr1:152193138 HRNR -0.46 -5.35 -0.31 1.91e-7 Atopic dermatitis; CESC cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg21918786 chr6:109611834 NA -0.35 -5.03 -0.3 8.9e-7 Reticulocyte fraction of red cells; CESC cis rs6496667 0.586 rs7162687 chr15:90889323 C/T cg22089800 chr15:90895588 ZNF774 -0.48 -5.84 -0.34 1.52e-8 Rheumatoid arthritis; CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg23131131 chr22:24373011 LOC391322 0.64 8.64 0.47 5.25e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg11752832 chr7:134001865 SLC35B4 0.54 7.09 0.4 1.19e-11 Mean platelet volume; CESC cis rs9486719 1.000 rs11752584 chr6:96884952 C/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs9815354 0.767 rs79323474 chr3:42000973 C/T cg03022575 chr3:42003672 ULK4 0.66 5.77 0.33 2.17e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs919433 0.889 rs10931782 chr2:198211579 G/A cg03934865 chr2:198174659 NA -0.45 -6.47 -0.37 4.63e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs2433610 1 rs2433610 chr15:45686091 C/T cg18489146 chr19:39759357 IL28A 0.89 6.25 0.36 1.66e-9 Serum metabolite levels; CESC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.93 -0.56 3.49e-23 Alzheimer's disease; CESC cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg06970220 chr1:156163860 SLC25A44 0.39 5.19 0.3 4.29e-7 Testicular germ cell tumor; CESC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs10851478 0.836 rs11070706 chr15:49845296 T/C cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs34779708 0.931 rs34815241 chr10:35296676 T/C cg04310649 chr10:35416472 CREM -0.49 -5.93 -0.34 9.63e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16004202 chr4:159689901 FNIP2 0.63 6.98 0.39 2.39e-11 Gut microbiome composition (summer); CESC cis rs13392177 0.672 rs1877715 chr2:219052546 C/T cg00012203 chr2:219082015 ARPC2 0.73 9.48 0.5 1.53e-18 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs7937682 0.889 rs493865 chr11:111495178 A/C cg09085632 chr11:111637200 PPP2R1B -0.94 -14.68 -0.67 4.23e-36 Primary sclerosing cholangitis; CESC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -6.41 -0.37 6.46e-10 Mood instability; CESC trans rs6951245 0.638 rs4720486 chr7:1146764 G/A cg13565492 chr6:43139072 SRF -0.72 -8.53 -0.46 1.17e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.77 10.14 0.53 1.23e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.02 -0.4 1.82e-11 Personality dimensions; CESC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg06108461 chr20:60628389 TAF4 -0.79 -11.4 -0.57 8.95e-25 Body mass index; CESC cis rs6121246 0.559 rs6060952 chr20:30382108 T/G cg13852791 chr20:30311386 BCL2L1 0.82 10.47 0.54 1.07e-21 Mean corpuscular hemoglobin; CESC cis rs7680126 0.596 rs35782983 chr4:10117728 G/A cg00071950 chr4:10020882 SLC2A9 -0.6 -6.78 -0.38 7.84e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1784581 0.588 rs9295180 chr6:162420579 T/C cg17173639 chr6:162384350 PARK2 0.56 8.62 0.47 6.34e-16 Itch intensity from mosquito bite; CESC cis rs2841277 0.676 rs10438247 chr14:105411781 G/A cg15352829 chr14:105391018 PLD4 -0.61 -10.84 -0.55 6.85e-23 Rheumatoid arthritis; CESC trans rs1814175 0.645 rs1963215 chr11:49931486 G/A cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg03433033 chr1:76189801 ACADM 0.6 6.04 0.35 5.3e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg08888203 chr3:10149979 C3orf24 0.46 5.94 0.34 9.02e-9 Alzheimer's disease; CESC cis rs2072499 1.000 rs2072499 chr1:156169610 A/G cg24450063 chr1:156163899 SLC25A44 1.08 22.52 0.81 1.8e-63 Testicular germ cell tumor; CESC cis rs208520 0.545 rs6899712 chr6:66749670 T/C cg07460842 chr6:66804631 NA 1.0 19.81 0.77 3.24e-54 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21517865 chr17:4046969 ZZEF1;CYB5D2 0.59 6.73 0.38 1.03e-10 Gut microbiome composition (summer); CESC cis rs854765 0.663 rs16960744 chr17:17755259 A/G cg04398451 chr17:18023971 MYO15A 0.63 9.18 0.49 1.25e-17 Total body bone mineral density; CESC cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg19193384 chr17:30244184 NA -0.66 -6.21 -0.36 2.01e-9 Hip circumference adjusted for BMI; CESC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg17971929 chr21:40555470 PSMG1 1.01 14.05 0.65 6.8e-34 Cognitive function; CESC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg03709012 chr19:19516395 GATAD2A 0.96 14.18 0.66 2.35e-34 Tonsillectomy; CESC cis rs1062177 1.000 rs12518722 chr5:151231460 A/G cg00977110 chr5:151150581 G3BP1 0.63 6.75 0.38 9.5e-11 Preschool internalizing problems; CESC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg23590916 chr17:43697445 MGC57346 -0.61 -6.5 -0.37 3.94e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12500824 0.535 rs17001890 chr4:77305346 A/G cg20311846 chr4:77356250 SHROOM3 0.37 7.27 0.41 4.03e-12 Coronary artery disease; CESC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.62 8.14 0.45 1.52e-14 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00215801 chr6:34855797 TAF11;ANKS1A 0.63 7.34 0.41 2.56e-12 Gut microbiome composition (summer); CESC cis rs9549367 0.789 rs3850451 chr13:113905812 C/G cg18105134 chr13:113819100 PROZ -0.72 -8.77 -0.47 2.21e-16 Platelet distribution width; CESC cis rs9303280 0.936 rs12950209 chr17:38049102 T/C cg19468946 chr17:37922297 IKZF3 -0.42 -5.6 -0.33 5.39e-8 Self-reported allergy; CESC cis rs2953174 0.786 rs8662 chr2:241517770 G/A cg07929629 chr2:241523174 NA 0.55 6.18 0.35 2.47e-9 Bipolar disorder; CESC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg19592336 chr6:28129416 ZNF389 0.52 6.71 0.38 1.18e-10 Parkinson's disease; CESC cis rs11122272 0.735 rs722302 chr1:231480152 A/C cg06096015 chr1:231504339 EGLN1 0.43 6.41 0.37 6.78e-10 Hemoglobin concentration; CESC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg10691866 chr7:65817282 TPST1 0.31 5.27 0.31 2.76e-7 Aortic root size; CESC cis rs9303401 0.659 rs62081316 chr17:56781499 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC trans rs13395018 0.892 rs10084272 chr2:170947923 G/A cg09813610 chr5:3601357 IRX1 -0.56 -6.01 -0.35 6.23e-9 Pulse pressure; CESC cis rs2243480 0.522 rs12698511 chr7:65474919 G/T cg05590025 chr7:65112418 INTS4L2 -0.75 -5.21 -0.31 3.73e-7 Diabetic kidney disease; CESC cis rs2820292 0.595 rs4950796 chr1:201835409 G/A cg06775570 chr1:201857621 SHISA4 -0.33 -5.16 -0.3 4.78e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07494914 chr16:46461571 NA 0.43 6.07 0.35 4.39e-9 Fibrinogen levels; CESC cis rs360798 0.512 rs4461246 chr2:63027671 C/T cg17519650 chr2:63277830 OTX1 -0.57 -7.41 -0.41 1.71e-12 Coronary artery disease; CESC trans rs11039798 0.588 rs12278284 chr11:48612063 G/C cg15704280 chr7:45808275 SEPT13 0.62 6.57 0.37 2.63e-10 Axial length; CESC cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg00290607 chr11:67383545 NA 0.45 6.35 0.36 9.22e-10 Mean corpuscular volume; CESC cis rs1461503 0.966 rs10892938 chr11:122841921 A/C cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs4253772 0.530 rs9615362 chr22:46795141 A/C cg24881330 chr22:46731750 TRMU -0.67 -6.53 -0.37 3.41e-10 LDL cholesterol;Cholesterol, total; CESC cis rs8067354 0.574 rs1292035 chr17:57989557 G/A cg02344993 chr17:57696989 CLTC 0.53 5.48 0.32 9.75e-8 Hemoglobin concentration; CESC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg11987759 chr7:65425863 GUSB -0.47 -6.44 -0.37 5.7e-10 Calcium levels; CESC cis rs7312933 0.558 rs2178753 chr12:42732804 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.49 -6.37 -0.36 8.12e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg05564831 chr3:52568323 NT5DC2 0.44 6.62 0.38 1.94e-10 Bipolar disorder; CESC cis rs7267979 0.528 rs34485039 chr20:25583763 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.69 -11.13 -0.56 7.53e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs9929218 0.906 rs4783571 chr16:68806778 C/T cg02972257 chr16:68554789 NA 0.43 5.12 0.3 5.89e-7 Colorectal cancer; CESC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg06420487 chr17:61919686 SMARCD2 0.43 5.13 0.3 5.59e-7 Height; CESC cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -8.52 -0.46 1.24e-15 Hemoglobin concentration; CESC cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.31 0.31 2.3e-7 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg14440974 chr22:39074834 NA -0.42 -5.65 -0.33 4.24e-8 Menopause (age at onset); CESC cis rs4566357 0.615 rs2272202 chr2:227914625 C/T cg05526886 chr2:227700861 RHBDD1 0.45 5.89 0.34 1.16e-8 Coronary artery disease; CESC cis rs7208859 0.623 rs9912440 chr17:29148772 A/G cg13385521 chr17:29058706 SUZ12P 0.8 6.7 0.38 1.22e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6693567 0.565 rs3754217 chr1:150480373 G/T cg09579323 chr1:150459698 TARS2 0.47 5.73 0.33 2.76e-8 Migraine; CESC cis rs9611565 0.649 rs2064189 chr22:42127999 A/G cg03806693 chr22:41940476 POLR3H 0.74 9.02 0.48 3.81e-17 Vitiligo; CESC cis rs2806561 0.514 rs7414010 chr1:23543929 T/C cg19743168 chr1:23544995 NA 0.38 5.79 0.33 2.03e-8 Height; CESC cis rs2204008 0.774 rs8189620 chr12:38241621 A/G cg26384229 chr12:38710491 ALG10B 0.72 10.15 0.53 1.19e-20 Bladder cancer; CESC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs367615 0.552 rs2963025 chr5:108733256 A/C cg17395555 chr5:108820864 NA -0.45 -7.49 -0.42 1.03e-12 Colorectal cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 1.000 rs112794590 chr7:12319426 G/A cg20607287 chr7:12443886 VWDE -0.79 -8.51 -0.46 1.32e-15 Coronary artery disease; CESC cis rs3806843 1.000 rs3756339 chr5:140180537 A/G cg26395211 chr5:140044315 WDR55 -0.42 -5.35 -0.31 1.9e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2228479 0.681 rs2270461 chr16:89972345 C/T cg06558623 chr16:89946397 TCF25 -0.55 -5.51 -0.32 8.65e-8 Skin colour saturation; CESC cis rs66887589 0.934 rs7672519 chr4:120544112 C/T cg09307838 chr4:120376055 NA -0.46 -6.27 -0.36 1.5e-9 Diastolic blood pressure; CESC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg27165867 chr14:105738592 BRF1 -0.55 -6.16 -0.35 2.66e-9 Mean platelet volume;Platelet distribution width; CESC trans rs9929218 0.551 rs2281850 chr16:68718750 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.96 -16.72 -0.72 2.37e-43 Colorectal cancer; CESC cis rs447735 0.587 rs258335 chr16:89720944 G/A cg03605463 chr16:89740564 NA 0.42 5.23 0.31 3.4e-7 Hemoglobin concentration; CESC cis rs2408955 0.522 rs2051851 chr12:48485940 G/C cg04545296 chr12:48745243 ZNF641 -0.35 -6.11 -0.35 3.47e-9 Glycated hemoglobin levels; CESC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg18765753 chr7:1198926 ZFAND2A -0.45 -6.54 -0.37 3.23e-10 Longevity;Endometriosis; CESC cis rs6831352 0.918 rs29001216 chr4:100051556 A/T cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg05368731 chr17:41323189 NBR1 0.8 11.39 0.57 9.99e-25 Menopause (age at onset); CESC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg00149659 chr3:10157352 C3orf10 0.72 8.45 0.46 1.95e-15 Alzheimer's disease; CESC cis rs2204008 0.540 rs1283306 chr12:38153778 C/A cg26384229 chr12:38710491 ALG10B -0.42 -5.74 -0.33 2.61e-8 Bladder cancer; CESC cis rs9611565 0.729 rs132902 chr22:41797758 A/G cg03806693 chr22:41940476 POLR3H -1.12 -15.13 -0.68 1.07e-37 Vitiligo; CESC cis rs9837602 1.000 rs4571265 chr3:99705111 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.53 -7.24 -0.41 4.82e-12 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08142232 chr20:32399298 CHMP4B 0.55 5.99 0.35 6.71e-9 Gut microbiome composition (summer); CESC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg11941060 chr3:133502564 NA -0.48 -6.53 -0.37 3.39e-10 Iron status biomarkers; CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg16145915 chr7:1198662 ZFAND2A -0.53 -6.5 -0.37 4.07e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6032067 0.929 rs1997892 chr20:43810961 A/T cg11264863 chr20:43835661 SEMG1 0.47 5.24 0.31 3.3e-7 Blood protein levels; CESC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 11.53 0.58 3.49e-25 Personality dimensions; CESC cis rs9457247 0.935 rs2757046 chr6:167374353 C/T cg25258033 chr6:167368657 RNASET2 -0.42 -6.29 -0.36 1.31e-9 Crohn's disease; CESC cis rs10242455 0.702 rs17161726 chr7:99008395 C/G cg25640893 chr7:99214727 ZNF498 0.96 6.28 0.36 1.41e-9 Blood metabolite levels; CESC cis rs3096299 0.900 rs4785666 chr16:89462771 C/G cg16743903 chr16:89593216 SPG7 -0.39 -5.03 -0.3 9.17e-7 Multiple myeloma (IgH translocation); CESC cis rs10733682 0.659 rs1887970 chr9:129464827 C/T cg00232160 chr9:129468157 NA 0.4 6.38 0.36 7.99e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11785693 0.909 rs11784246 chr8:4970497 A/G cg26367366 chr8:4980734 NA 0.81 7.25 0.41 4.53e-12 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs459571 0.920 rs433402 chr9:136898627 A/G cg13789015 chr9:136890014 NCRNA00094 0.55 7.69 0.43 2.94e-13 Platelet distribution width; CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg18765753 chr7:1198926 ZFAND2A -0.58 -8.86 -0.48 1.18e-16 Longevity;Endometriosis; CESC cis rs1348850 0.872 rs2084233 chr2:178331206 G/A cg22681709 chr2:178499509 PDE11A -0.42 -5.99 -0.35 6.97e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8062405 1.000 rs55719896 chr16:28846866 G/A cg08761264 chr16:28874980 SH2B1 -0.46 -5.77 -0.33 2.26e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs7937682 0.855 rs7109592 chr11:111533105 C/A cg18187862 chr3:45730750 SACM1L 0.47 6.04 0.35 5.2e-9 Primary sclerosing cholangitis; CESC cis rs6693567 0.545 rs35705743 chr1:150451832 G/A cg09579323 chr1:150459698 TARS2 0.48 6.02 0.35 5.7e-9 Migraine; CESC cis rs7078219 0.505 rs10883365 chr10:101287764 C/T cg09788492 chr10:101292477 NKX2-3 0.33 6.19 0.36 2.28e-9 Dental caries; CESC cis rs7296418 0.961 rs949143 chr12:123595163 G/A cg05973401 chr12:123451056 ABCB9 0.58 7.68 0.43 3.16e-13 Platelet count; CESC cis rs4964805 0.710 rs1866296 chr12:104187092 G/A cg02344784 chr12:104178138 NT5DC3 0.46 6.57 0.37 2.73e-10 Attention deficit hyperactivity disorder; CESC cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg16339924 chr4:17578868 LAP3 -0.66 -7.98 -0.44 4.41e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg07755735 chr2:20870362 GDF7 -0.47 -7.07 -0.4 1.35e-11 Abdominal aortic aneurysm; CESC cis rs1348850 0.574 rs13431105 chr2:178434674 A/G cg22681709 chr2:178499509 PDE11A -0.52 -5.2 -0.3 3.95e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs17780086 0.527 rs72827711 chr17:30537920 T/A cg20587970 chr11:113659929 NA -1.24 -11.04 -0.56 1.46e-23 Height; CESC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg06873352 chr17:61820015 STRADA 0.65 11.05 0.56 1.35e-23 Prudent dietary pattern; CESC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg23758822 chr17:41437982 NA -0.98 -17.21 -0.73 4.39e-45 Menopause (age at onset); CESC cis rs10743315 0.778 rs9805106 chr12:19372357 A/G cg02471346 chr12:19282374 PLEKHA5 -0.48 -5.2 -0.3 4.07e-7 Gut microbiota (bacterial taxa); CESC cis rs6582630 0.638 rs10880644 chr12:38554959 G/A cg26384229 chr12:38710491 ALG10B 0.45 6.3 0.36 1.22e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs3738443 0.645 rs11811599 chr1:247366435 C/A cg07706540 chr1:247373924 NA -0.41 -5.09 -0.3 6.82e-7 Alcohol dependence; CESC trans rs9929218 0.911 rs4783686 chr16:68834156 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.64 -8.03 -0.44 3.13e-14 Colorectal cancer; CESC cis rs4148883 0.504 rs4585310 chr4:100120233 T/C cg12011299 chr4:100065546 ADH4 -0.52 -7.3 -0.41 3.3e-12 Alcohol dependence; CESC cis rs7666738 0.719 rs35184673 chr4:99050945 T/C cg17366294 chr4:99064904 C4orf37 0.57 6.06 0.35 4.58e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9581857 0.615 rs3759435 chr13:27996813 T/G cg22138327 chr13:27999177 GTF3A 0.8 8.32 0.46 4.65e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs9314323 0.558 rs7828560 chr8:26188998 G/A cg11498726 chr8:26250323 BNIP3L -0.43 -6.08 -0.35 4.16e-9 Red cell distribution width; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15380588 chr6:144606480 NA -0.45 -6.01 -0.35 6.17e-9 Fibrinogen levels; CESC cis rs2635047 0.638 rs2317324 chr18:44628687 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.42 -5.36 -0.31 1.78e-7 Educational attainment; CESC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg19622623 chr12:86230825 RASSF9 -0.47 -6.07 -0.35 4.34e-9 Major depressive disorder; CESC cis rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13636640 chr20:31349939 DNMT3B 0.84 13.53 0.64 4.51e-32 Ulcerative colitis; CESC cis rs7100689 0.646 rs11202721 chr10:82135762 G/A cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg27266027 chr21:40555129 PSMG1 0.44 5.24 0.31 3.26e-7 Cognitive function; CESC cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg16144293 chr14:75469539 EIF2B2 0.42 5.57 0.32 6.39e-8 Height; CESC cis rs9611565 0.592 rs5758405 chr22:42076381 C/A cg06634786 chr22:41940651 POLR3H 0.58 6.02 0.35 5.72e-9 Vitiligo; CESC cis rs2991971 0.810 rs781058 chr1:45935056 C/G cg05343316 chr1:45956843 TESK2 0.58 8.44 0.46 2.06e-15 High light scatter reticulocyte count; CESC cis rs763014 0.865 rs2018789 chr16:632051 T/C cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC cis rs71277158 0.630 rs73879159 chr3:169753747 G/T cg04067573 chr3:169899625 PHC3 0.57 5.71 0.33 2.95e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15203618 chr11:85646125 NA -0.59 -6.82 -0.39 6.23e-11 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg22920501 chr2:26401640 FAM59B 0.92 10.12 0.53 1.47e-20 Gut microbiome composition (summer); CESC cis rs2228479 0.867 rs57492102 chr16:89975572 A/G cg00800038 chr16:89945340 TCF25 -0.75 -7.05 -0.4 1.54e-11 Skin colour saturation; CESC cis rs829883 0.646 rs4762494 chr12:98933834 T/G cg25150519 chr12:98850993 NA -0.64 -7.87 -0.44 8.8e-14 Colorectal adenoma (advanced); CESC cis rs9303401 0.614 rs3803752 chr17:56540267 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.95 10.53 0.54 7.11e-22 Cognitive test performance; CESC cis rs9611565 0.512 rs4512 chr22:42206084 G/C cg06634786 chr22:41940651 POLR3H -0.66 -6.31 -0.36 1.15e-9 Vitiligo; CESC cis rs4466137 0.868 rs4703962 chr5:82999808 A/G cg16102102 chr5:83017553 HAPLN1 -0.47 -6.74 -0.38 9.88e-11 Prostate cancer; CESC cis rs2404602 0.716 rs7174953 chr15:76906847 A/C cg26408565 chr15:76604113 ETFA -0.4 -5.73 -0.33 2.73e-8 Blood metabolite levels; CESC cis rs7584330 0.554 rs880931 chr2:238396741 G/A cg14458575 chr2:238380390 NA 0.68 5.98 0.34 7.17e-9 Prostate cancer; CESC trans rs11148252 0.532 rs9536190 chr13:53181044 T/C cg18335740 chr13:41363409 SLC25A15 0.57 7.6 0.42 5.06e-13 Lewy body disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18447950 chr17:79073781 BAIAP2 0.51 6.95 0.39 2.89e-11 Fibrinogen levels; CESC cis rs2637266 0.521 rs4587671 chr10:78398879 A/G cg18941641 chr10:78392320 NA -0.35 -5.58 -0.32 6.05e-8 Pulmonary function; CESC cis rs1040555 0.516 rs242547 chr20:31418581 T/C cg13636640 chr20:31349939 DNMT3B 0.68 9.79 0.52 1.66e-19 Lymphocyte percentage of white cells; CESC cis rs1728785 0.792 rs1111502 chr16:68581209 A/G cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs9612 0.718 rs346536 chr19:44251470 A/T cg08581076 chr19:44259116 C19orf61 0.43 5.24 0.31 3.2e-7 Exhaled nitric oxide output; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24701985 chr7:149535383 ZNF862 -0.45 -6.41 -0.37 6.6e-10 Gambling; CESC cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.07 0.3 7.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.607 rs4819212 chr21:44977455 G/A cg21573476 chr21:45109991 RRP1B -0.4 -5.4 -0.32 1.46e-7 Mean corpuscular volume; CESC cis rs2777491 0.957 rs1757454 chr15:41777934 A/G cg20272979 chr15:41787780 ITPKA 0.42 6.19 0.36 2.29e-9 Ulcerative colitis; CESC cis rs6747952 0.866 rs4663854 chr2:239083167 C/T cg17459225 chr2:239074497 NA -0.32 -5.04 -0.3 8.55e-7 Mean corpuscular hemoglobin concentration; CESC cis rs36051895 0.664 rs3780374 chr9:5099677 G/A cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.61e-9 Pediatric autoimmune diseases; CESC cis rs8017423 0.967 rs4904656 chr14:90721442 G/T cg14092571 chr14:90743983 NA -0.55 -8.25 -0.45 7.71e-15 Mortality in heart failure; CESC cis rs9388451 0.872 rs2008027 chr6:126052359 A/G cg05901451 chr6:126070800 HEY2 -0.63 -9.12 -0.49 2.01e-17 Brugada syndrome; CESC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg09913183 chr17:42254507 C17orf65;ASB16 0.61 8.0 0.44 3.92e-14 Total body bone mineral density; CESC cis rs7845219 0.544 rs9643352 chr8:95918288 C/T cg13393036 chr8:95962371 TP53INP1 -0.42 -7.77 -0.43 1.69e-13 Type 2 diabetes; CESC cis rs722599 0.715 rs2080086 chr14:75338408 G/A cg11812906 chr14:75593930 NEK9 -0.44 -5.51 -0.32 8.58e-8 IgG glycosylation; CESC cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg11366901 chr6:160182831 ACAT2 0.77 9.45 0.5 1.88e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg13798912 chr7:905769 UNC84A -0.58 -5.66 -0.33 3.86e-8 Cerebrospinal P-tau181p levels; CESC cis rs8067354 1.000 rs8067354 chr17:57821430 G/A cg13753209 chr17:57696993 CLTC 0.53 7.05 0.4 1.58e-11 Hemoglobin concentration; CESC cis rs2070677 0.935 rs4384343 chr10:135422545 G/C cg20169779 chr10:135381914 SYCE1 -0.74 -9.88 -0.52 8.58e-20 Gout; CESC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg17178900 chr1:205818956 PM20D1 0.46 6.59 0.38 2.3e-10 Menarche (age at onset); CESC cis rs11997175 0.603 rs12234894 chr8:33699275 G/C ch.8.33884649F chr8:33765107 NA 0.56 7.34 0.41 2.56e-12 Body mass index; CESC trans rs17685 0.725 rs4728548 chr7:75654632 A/T cg19862616 chr7:65841803 NCRNA00174 -0.7 -9.33 -0.5 4.53e-18 Coffee consumption;Coffee consumption (cups per day); CESC cis rs13392177 0.684 rs11695527 chr2:219068103 A/G cg00012203 chr2:219082015 ARPC2 0.64 8.13 0.45 1.7e-14 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs9325144 0.681 rs7957376 chr12:39096518 C/T cg26384229 chr12:38710491 ALG10B 0.45 5.19 0.3 4.26e-7 Morning vs. evening chronotype; CESC cis rs2486288 0.656 rs11632724 chr15:45550791 G/A cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs4523957 0.690 rs28505924 chr17:2088838 G/C cg16513277 chr17:2031491 SMG6 -0.7 -9.59 -0.51 6.78e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg05368731 chr17:41323189 NBR1 0.77 10.67 0.55 2.44e-22 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01102197 chr9:135753538 C9orf98;C9orf9 -0.42 -6.04 -0.35 5.14e-9 Gambling; CESC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg19163074 chr7:65112434 INTS4L2 0.42 5.28 0.31 2.63e-7 Aortic root size; CESC cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.81 7.42 0.41 1.58e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01288993 chr7:99631485 ZKSCAN1 -0.73 -8.15 -0.45 1.49e-14 Gut microbiome composition (summer); CESC cis rs684232 0.602 rs384628 chr17:554912 G/A cg15660573 chr17:549704 VPS53 -0.8 -11.67 -0.58 1.16e-25 Prostate cancer; CESC cis rs4563143 0.675 rs55849754 chr19:29279665 G/A cg12756686 chr19:29218302 NA 0.58 7.36 0.41 2.38e-12 Methadone dose in opioid dependence; CESC cis rs9916302 0.904 rs12452880 chr17:37591149 G/C cg00129232 chr17:37814104 STARD3 -0.59 -7.8 -0.43 1.45e-13 Glomerular filtration rate (creatinine); CESC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg24531977 chr5:56204891 C5orf35 -0.87 -11.43 -0.57 7.1e-25 Initial pursuit acceleration; CESC cis rs7605827 0.930 rs3805105 chr2:15535312 T/A cg19274914 chr2:15703543 NA 0.37 6.74 0.38 9.98e-11 Educational attainment (years of education); CESC cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.75 11.04 0.56 1.49e-23 Hip circumference adjusted for BMI; CESC cis rs7223966 1.000 rs9899491 chr17:61934384 G/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.16 -0.3 4.76e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg16339924 chr4:17578868 LAP3 0.74 9.68 0.51 3.59e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs1994135 0.565 rs11052767 chr12:33731194 A/G cg26384229 chr12:38710491 ALG10B 0.48 6.52 0.37 3.62e-10 Resting heart rate; CESC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg27170947 chr2:26402098 FAM59B -0.63 -7.23 -0.41 5.09e-12 Gut microbiome composition (summer); CESC cis rs11166927 1.000 rs11166929 chr8:140801430 G/A cg16909799 chr8:140841666 TRAPPC9 0.57 8.49 0.46 1.52e-15 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs4727027 0.865 rs62505077 chr7:148849656 T/A cg23583168 chr7:148888333 NA -0.81 -12.69 -0.61 3.68e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09504196 chr7:148823235 ZNF425;ZNF398 -0.43 -6.16 -0.35 2.74e-9 Gambling; CESC cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg03433033 chr1:76189801 ACADM -0.62 -6.54 -0.37 3.12e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7072216 0.763 rs733345 chr10:100164215 G/T cg26618903 chr10:100175079 PYROXD2 -0.35 -5.33 -0.31 2.15e-7 Metabolite levels; CESC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg11644478 chr21:40555479 PSMG1 -0.76 -10.97 -0.56 2.48e-23 Cognitive function; CESC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg21770322 chr7:97807741 LMTK2 0.54 8.15 0.45 1.45e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs4704187 0.687 rs4295370 chr5:74528858 G/T cg03227963 chr5:74354835 NA 0.28 5.17 0.3 4.61e-7 Response to amphetamines; CESC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg12412775 chr1:25698385 RHCE -0.31 -5.49 -0.32 9.57e-8 Erythrocyte sedimentation rate; CESC cis rs1707322 1.000 rs10890377 chr1:46406594 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01745726 chr22:24129337 SMARCB1 -0.51 -6.65 -0.38 1.67e-10 Fibrinogen levels; CESC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg11494091 chr17:61959527 GH2 0.73 12.75 0.62 2.36e-29 Prudent dietary pattern; CESC cis rs9457247 0.905 rs377232 chr6:167409638 C/A cg07741184 chr6:167504864 NA 0.32 5.7 0.33 3.12e-8 Crohn's disease; CESC cis rs13082711 0.863 rs13062327 chr3:27495573 G/A cg02860705 chr3:27208620 NA 0.51 6.33 0.36 1.06e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7259376 0.936 rs12608491 chr19:22541627 A/G cg02657401 chr19:22469223 NA -0.25 -5.08 -0.3 7.12e-7 Menopause (age at onset); CESC cis rs733175 0.599 rs6856396 chr4:10031163 A/T cg00071950 chr4:10020882 SLC2A9 0.54 5.09 0.3 6.82e-7 Psychosis and Alzheimer's disease; CESC cis rs763121 0.853 rs9610986 chr22:39025277 T/C cg06022373 chr22:39101656 GTPBP1 0.88 13.7 0.64 1.21e-32 Menopause (age at onset); CESC cis rs3741151 0.687 rs724111 chr11:73238645 G/A cg17517138 chr11:73019481 ARHGEF17 1.05 7.72 0.43 2.46e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs4141404 0.923 rs2413035 chr22:31600460 A/G cg13145458 chr22:31556086 RNF185 0.47 5.11 0.3 6.03e-7 Paclitaxel-induced neuropathy; CESC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg09263875 chr16:632152 PIGQ 0.68 11.59 0.58 2.18e-25 Height; CESC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg24549020 chr5:56110836 MAP3K1 0.66 7.45 0.42 1.29e-12 Initial pursuit acceleration; CESC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.16 0.81 2.84e-62 Prudent dietary pattern; CESC cis rs2033711 0.654 rs734380 chr19:58898963 A/C cg26874164 chr19:58962979 ZNF324B 0.38 5.21 0.3 3.77e-7 Uric acid clearance; CESC cis rs9787249 0.957 rs11809515 chr1:40205326 C/A cg19912559 chr1:40204330 PPIE 0.43 6.57 0.37 2.68e-10 Blood protein levels; CESC trans rs1728785 1.000 rs8058314 chr16:68584151 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.48 0.42 1.11e-12 Ulcerative colitis; CESC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg23281280 chr6:28129359 ZNF389 0.55 7.09 0.4 1.21e-11 Parkinson's disease; CESC cis rs7680126 0.596 rs17198547 chr4:10141419 A/G cg11266682 chr4:10021025 SLC2A9 0.38 5.44 0.32 1.19e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg18446336 chr7:2847575 GNA12 -0.35 -5.53 -0.32 7.65e-8 Height; CESC cis rs7605827 0.860 rs13425097 chr2:15528920 C/G cg19274914 chr2:15703543 NA 0.35 6.24 0.36 1.73e-9 Educational attainment (years of education); CESC cis rs2273669 0.667 rs75675305 chr6:109324353 T/C cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs11252926 0.603 rs17293419 chr10:537014 G/A cg03684893 chr10:554711 DIP2C 0.44 6.64 0.38 1.77e-10 Psychosis in Alzheimer's disease; CESC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg16132339 chr22:24313637 DDTL;DDT -0.38 -5.89 -0.34 1.19e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs733592 0.560 rs2158515 chr12:48507668 T/C cg24011408 chr12:48396354 COL2A1 -0.51 -8.44 -0.46 2.09e-15 Plateletcrit; CESC cis rs7937682 1.000 rs7128353 chr11:111538875 A/G cg22437258 chr11:111473054 SIK2 0.66 8.68 0.47 4.2e-16 Primary sclerosing cholangitis; CESC cis rs2304069 0.826 rs2244195 chr5:149403528 C/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.88 11.3 0.57 1.98e-24 HIV-1 control; CESC cis rs116095464 0.558 rs10057626 chr5:239720 T/G cg10591111 chr5:226296 SDHA -0.52 -6.32 -0.36 1.1e-9 Breast cancer; CESC cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg20573242 chr4:122745356 CCNA2 0.65 8.05 0.44 2.81e-14 Type 2 diabetes; CESC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg26354017 chr1:205819088 PM20D1 0.84 13.62 0.64 2.19e-32 Menarche (age at onset); CESC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.94 0.59 1.43e-26 Alzheimer's disease; CESC cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg27347728 chr4:17578864 LAP3 0.45 5.49 0.32 9.26e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1448094 0.648 rs10863093 chr12:86285792 T/G cg02569458 chr12:86230093 RASSF9 0.39 5.76 0.33 2.31e-8 Major depressive disorder; CESC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg22143856 chr6:28129313 ZNF389 -0.44 -5.57 -0.32 6.34e-8 Depression; CESC trans rs11098499 0.863 rs58452170 chr4:120459674 A/T cg25214090 chr10:38739885 LOC399744 0.69 9.51 0.5 1.19e-18 Corneal astigmatism; CESC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg00612595 chr21:47717864 NA 0.42 5.69 0.33 3.43e-8 Testicular germ cell tumor; CESC cis rs11792861 1.000 rs11792861 chr9:111809295 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.47 5.94 0.34 8.73e-9 Menarche (age at onset); CESC cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.12 0.3 5.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs73001065 0.536 rs10408596 chr19:19512657 A/T cg03709012 chr19:19516395 GATAD2A 0.93 7.68 0.43 3.03e-13 LDL cholesterol; CESC cis rs477692 0.597 rs574831 chr10:131379190 C/T cg05714579 chr10:131428358 MGMT -0.46 -6.26 -0.36 1.53e-9 Response to temozolomide; CESC cis rs72945132 0.714 rs115143889 chr11:70150122 G/T cg00319359 chr11:70116639 PPFIA1 0.82 7.48 0.42 1.07e-12 Coronary artery disease; CESC cis rs17818399 0.645 rs35870739 chr2:46784231 A/C cg02822958 chr2:46747628 ATP6V1E2 0.47 5.56 0.32 6.69e-8 Height; CESC cis rs854765 0.547 rs9897761 chr17:17912011 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.54 7.72 0.43 2.32e-13 Total body bone mineral density; CESC cis rs2479106 0.591 rs10760295 chr9:126441397 A/G cg16191174 chr9:126692580 DENND1A -0.4 -5.62 -0.33 4.77e-8 Polycystic ovary syndrome; CESC cis rs7786808 0.712 rs12671981 chr7:158202971 G/A cg01191920 chr7:158217561 PTPRN2 -0.36 -5.91 -0.34 1.04e-8 Obesity-related traits; CESC cis rs2635047 0.638 rs2635051 chr18:44645029 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.56 0.32 6.6e-8 Educational attainment; CESC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg08109568 chr15:31115862 NA -0.72 -9.88 -0.52 8.33e-20 Huntington's disease progression; CESC cis rs4566357 0.576 rs6750845 chr2:227911037 T/G cg05526886 chr2:227700861 RHBDD1 -0.45 -5.99 -0.35 6.98e-9 Coronary artery disease; CESC cis rs4975616 0.714 rs27069 chr5:1347128 C/T cg26373071 chr5:1325741 CLPTM1L 0.46 7.36 0.41 2.36e-12 Lung cancer; CESC cis rs12497850 1.000 rs4858798 chr3:48727112 C/T cg03060546 chr3:49711283 APEH 0.4 5.17 0.3 4.72e-7 Parkinson's disease; CESC cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg18904891 chr8:8559673 CLDN23 0.73 8.12 0.45 1.74e-14 Obesity-related traits; CESC cis rs7927771 0.524 rs11039402 chr11:47826090 A/C cg20307385 chr11:47447363 PSMC3 0.62 8.62 0.47 6.37e-16 Subjective well-being; CESC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg09177884 chr7:1199841 ZFAND2A -0.5 -6.21 -0.36 2.01e-9 Longevity;Endometriosis; CESC cis rs4722166 0.508 rs1474347 chr7:22768124 A/C cg05472934 chr7:22766657 IL6 -0.68 -8.88 -0.48 1.05e-16 Lung cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23620433 chr14:58894395 KIAA0586;TIMM9 -0.43 -6.33 -0.36 1.05e-9 Gut microbiota (bacterial taxa); CESC cis rs400736 0.637 rs2300428 chr1:7996894 A/G cg25007680 chr1:8021821 PARK7 -0.57 -8.03 -0.44 3.2e-14 Response to antidepressants and depression; CESC cis rs9916302 0.706 rs1877030 chr17:37740161 T/C cg00129232 chr17:37814104 STARD3 -0.56 -5.25 -0.31 3.08e-7 Glomerular filtration rate (creatinine); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13898697 chr1:36641773 MAP7D1 0.51 7.02 0.4 1.9e-11 Fibrinogen levels; CESC trans rs8135828 0.770 rs5763303 chr22:29929744 A/G cg17961835 chr3:126195582 ZXDC -0.45 -6.03 -0.35 5.5e-9 Lipid traits; CESC cis rs2463822 0.592 rs72919486 chr11:62043501 G/C cg06239285 chr11:62104954 ASRGL1 -1.13 -9.21 -0.49 1.05e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.21 -0.41 5.68e-12 Total body bone mineral density; CESC cis rs2070997 0.527 rs3847192 chr9:133724916 T/G cg11464064 chr9:133710261 ABL1 0.59 5.93 0.34 9.31e-9 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03043663 chr1:2344561 PEX10 0.62 7.4 0.41 1.77e-12 Gut microbiome composition (summer); CESC cis rs6570726 0.846 rs409553 chr6:145886963 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.59 0.38 2.33e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs11785400 0.701 rs9721143 chr8:143727511 A/T cg10596483 chr8:143751796 JRK 0.42 5.36 0.31 1.77e-7 Schizophrenia; CESC cis rs9790314 1.000 rs1993891 chr3:161047467 A/G cg03342759 chr3:160939853 NMD3 -0.47 -6.11 -0.35 3.61e-9 Morning vs. evening chronotype; CESC cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg21918786 chr6:109611834 NA -0.36 -5.26 -0.31 3.03e-7 Reticulocyte fraction of red cells; CESC cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg11752832 chr7:134001865 SLC35B4 -0.44 -5.51 -0.32 8.64e-8 Mean platelet volume; CESC cis rs7072216 0.691 rs7910973 chr10:100166732 G/A cg26618903 chr10:100175079 PYROXD2 -0.36 -5.38 -0.31 1.65e-7 Metabolite levels; CESC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg12648201 chr2:27665141 KRTCAP3 -0.32 -5.67 -0.33 3.75e-8 Total body bone mineral density; CESC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg04267008 chr7:1944627 MAD1L1 -0.63 -7.63 -0.42 4.34e-13 Bipolar disorder and schizophrenia; CESC cis rs6545883 0.929 rs7561229 chr2:61737990 A/T cg15711740 chr2:61764176 XPO1 -0.43 -5.21 -0.3 3.86e-7 Tuberculosis; CESC cis rs644799 0.965 rs687529 chr11:95545587 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg00033643 chr7:134001901 SLC35B4 0.43 5.48 0.32 9.9e-8 Mean platelet volume; CESC cis rs9457247 0.663 rs9457257 chr6:167440736 G/A cg23791538 chr6:167370224 RNASET2 -0.57 -7.71 -0.43 2.6e-13 Crohn's disease; CESC cis rs9815354 1.000 rs17064124 chr3:41890803 A/G cg03022575 chr3:42003672 ULK4 0.45 5.2 0.3 3.99e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs523522 0.962 rs4766966 chr12:120942911 G/C cg27279351 chr12:120934652 DYNLL1 0.69 8.94 0.48 6.79e-17 High light scatter reticulocyte count; CESC cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg20476274 chr7:133979776 SLC35B4 0.55 7.8 0.43 1.45e-13 Mean platelet volume; CESC cis rs8077577 0.689 rs62072515 chr17:18213435 T/G cg16794390 chr17:18148240 FLII 0.4 6.16 0.35 2.74e-9 Obesity-related traits; CESC cis rs2479724 0.811 rs8393 chr6:41757836 C/A cg08135965 chr6:41755394 TOMM6 -0.41 -5.26 -0.31 3e-7 Menarche (age at onset); CESC cis rs2279817 0.818 rs883379 chr1:17983789 G/A cg21791023 chr1:18019539 ARHGEF10L -0.55 -7.37 -0.41 2.21e-12 Neuroticism; CESC cis rs9457247 1.000 rs2769352 chr6:167378619 A/G cg23791538 chr6:167370224 RNASET2 0.58 8.26 0.45 7.1e-15 Crohn's disease; CESC cis rs7640424 0.784 rs68044584 chr3:107845395 A/G cg09227934 chr3:107805635 CD47 -0.46 -5.87 -0.34 1.28e-8 Body mass index; CESC cis rs9486719 0.947 rs12210834 chr6:96890407 A/T cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7851660 0.809 rs7034648 chr9:100654093 C/A cg13688889 chr9:100608707 NA -0.63 -8.96 -0.48 5.96e-17 Strep throat; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01936430 chr1:204380496 PPP1R15B -0.44 -6.26 -0.36 1.53e-9 Fibrinogen levels; CESC cis rs1046896 0.594 rs9914570 chr17:80783721 C/T cg19500275 chr17:80737654 TBCD 0.5 5.56 0.32 6.55e-8 Glycated hemoglobin levels; CESC cis rs9948 0.500 rs62152903 chr2:97570377 T/C cg26665480 chr2:98280029 ACTR1B -0.58 -5.22 -0.31 3.69e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs7927592 0.546 rs638076 chr11:68202580 A/G cg16797656 chr11:68205561 LRP5 0.63 9.89 0.52 7.78e-20 Total body bone mineral density; CESC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.68 6.93 0.39 3.14e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28489187 0.756 rs233047 chr1:85830570 G/A cg16011679 chr1:85725395 C1orf52 0.5 5.67 0.33 3.81e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs3096299 0.582 rs12935119 chr16:89542874 A/T cg00750074 chr16:89608354 SPG7 -0.41 -6.01 -0.35 6.05e-9 Multiple myeloma (IgH translocation); CESC cis rs2439831 1.000 rs2584725 chr15:43793135 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.17 0.6 2.26e-27 Lung cancer in ever smokers; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26650539 chr6:34664812 C6orf106 0.38 6.12 0.35 3.28e-9 Gambling; CESC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg11644478 chr21:40555479 PSMG1 1.03 17.22 0.73 4.12e-45 Cognitive function; CESC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg25204440 chr1:209979598 IRF6 0.54 7.28 0.41 3.71e-12 Cleft lip with or without cleft palate; CESC cis rs1957429 0.614 rs73279834 chr14:65352544 G/A cg23373153 chr14:65346875 NA -0.92 -6.68 -0.38 1.43e-10 Pediatric areal bone mineral density (radius); CESC trans rs61931739 0.500 rs11519398 chr12:34473553 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.21 0.36 2.09e-9 Morning vs. evening chronotype; CESC cis rs9900062 0.519 rs2676293 chr17:62710461 T/C cg02097616 chr17:62675921 NA 0.42 5.09 0.3 6.69e-7 QT interval; CESC cis rs7084402 0.870 rs4948525 chr10:60361270 G/A cg07615347 chr10:60278583 BICC1 0.57 8.73 0.47 2.99e-16 Refractive error; CESC trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg15704280 chr7:45808275 SEPT13 0.96 15.84 0.7 3.3e-40 Height; CESC cis rs4481887 1.000 rs7553333 chr1:248493956 C/G cg00666640 chr1:248458726 OR2T12 0.41 6.71 0.38 1.17e-10 Common traits (Other); CESC cis rs7223966 1.000 rs8081541 chr17:61812483 C/T cg11494091 chr17:61959527 GH2 0.38 5.15 0.3 5.2e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4908760 0.783 rs301799 chr1:8489302 C/T cg00120948 chr1:8484417 RERE -0.41 -6.49 -0.37 4.19e-10 Vitiligo; CESC cis rs854765 0.583 rs11656840 chr17:17837354 C/T cg04398451 chr17:18023971 MYO15A -0.67 -9.61 -0.51 5.88e-19 Total body bone mineral density; CESC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg07507251 chr3:52567010 NT5DC2 -0.44 -7.2 -0.4 6.11e-12 Bipolar disorder; CESC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg18225595 chr11:63971243 STIP1 0.67 9.29 0.5 5.92e-18 Platelet count; CESC cis rs4481887 1.000 rs4916125 chr1:248466583 A/T cg00666640 chr1:248458726 OR2T12 0.39 6.37 0.36 8.47e-10 Common traits (Other); CESC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.55 0.37 2.89e-10 Bipolar disorder; CESC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs748404 0.660 rs493377 chr15:43773467 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.42 0.41 1.57e-12 Lung cancer; CESC cis rs1879734 0.689 rs11206191 chr1:54158102 A/G cg23596471 chr1:54105337 GLIS1 -0.33 -5.39 -0.31 1.58e-7 Mitral valve prolapse; CESC cis rs10089 0.953 rs4836358 chr5:127376869 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.15 0.53 1.14e-20 Ileal carcinoids; CESC cis rs4141404 0.561 rs5994376 chr22:31563555 A/C cg25791279 chr22:32026902 PISD -0.42 -5.04 -0.3 8.61e-7 Paclitaxel-induced neuropathy; CESC cis rs10779751 0.686 rs2791656 chr1:11128329 A/G cg08854313 chr1:11322531 MTOR 0.76 9.57 0.51 8.15e-19 Body mass index; CESC cis rs9911578 0.765 rs66954617 chr17:56999427 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.04 0.3 8.51e-7 Intelligence (multi-trait analysis); CESC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14729071 chr8:117886537 RAD21 -0.44 -6.08 -0.35 4.08e-9 Gambling; CESC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg02725872 chr8:58115012 NA -0.4 -6.25 -0.36 1.67e-9 Developmental language disorder (linguistic errors); CESC trans rs2273788 1.000 rs2273788 chr9:114348617 C/T cg05983323 chr4:166249203 SC4MOL -0.61 -6.15 -0.35 2.86e-9 Monocyte count; CESC cis rs12477438 0.520 rs6542864 chr2:99725223 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.89 15.87 0.7 2.44e-40 Chronic sinus infection; CESC cis rs10838687 0.736 rs11039144 chr11:47264044 G/A cg25783544 chr11:47291846 MADD 0.56 6.5 0.37 4.04e-10 Proinsulin levels; CESC cis rs2228479 0.850 rs62054609 chr16:89816569 C/A cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs3026401 0.562 rs2863231 chr11:31796560 C/T cg14844989 chr11:31128820 NA -0.53 -6.68 -0.38 1.4e-10 Body mass index; CESC cis rs5769765 1.000 rs4597652 chr22:50270570 A/G cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC trans rs7836436 0.686 rs61519992 chr8:120954517 A/C cg22699279 chr15:79383890 RASGRF1 -0.7 -6.72 -0.38 1.12e-10 HIV-1 viral setpoint; CESC cis rs4423214 1.000 rs7928249 chr11:71161063 A/G cg24826892 chr11:71159390 DHCR7 0.45 5.38 0.31 1.68e-7 Vitamin D levels; CESC cis rs17376456 0.757 rs6859757 chr5:93206042 C/T cg25358565 chr5:93447407 FAM172A 1.13 10.54 0.54 6.44e-22 Diabetic retinopathy; CESC cis rs7520050 0.966 rs1707336 chr1:46493460 T/G cg24296786 chr1:45957014 TESK2 0.43 5.42 0.32 1.33e-7 Red blood cell count;Reticulocyte count; CESC cis rs67478160 0.595 rs2295146 chr14:104199356 C/T cg01849466 chr14:104193079 ZFYVE21 -0.53 -7.32 -0.41 2.97e-12 Schizophrenia; CESC cis rs9487051 0.676 rs9372208 chr6:109596168 A/G cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg23158103 chr7:148848205 ZNF398 -0.4 -6.29 -0.36 1.31e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg20503657 chr10:835505 NA 0.74 6.75 0.38 9.51e-11 Eosinophil percentage of granulocytes; CESC cis rs6546537 0.869 rs13035491 chr2:69827456 G/A cg10773587 chr2:69614142 GFPT1 -0.55 -6.86 -0.39 4.72e-11 Serum thyroid-stimulating hormone levels; CESC trans rs116095464 0.558 rs6962 chr5:256509 G/A cg00938859 chr5:1591904 SDHAP3 0.69 6.93 0.39 3.2e-11 Breast cancer; CESC cis rs7546094 0.509 rs7415988 chr1:113159730 G/T cg22162597 chr1:113214053 CAPZA1 -0.62 -7.57 -0.42 6.29e-13 Platelet distribution width; CESC cis rs7937682 0.855 rs521947 chr11:111492616 A/G cg22437258 chr11:111473054 SIK2 0.72 9.66 0.51 4.24e-19 Primary sclerosing cholangitis; CESC cis rs8060686 0.920 rs1124324 chr16:67897487 C/T cg26727032 chr16:67993705 SLC12A4 -0.48 -5.62 -0.33 4.79e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg02034447 chr16:89574710 SPG7 0.46 5.92 0.34 9.77e-9 Multiple myeloma (IgH translocation); CESC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg03806693 chr22:41940476 POLR3H 1.09 12.68 0.61 4.08e-29 Crohn's disease;Inflammatory bowel disease; CESC cis rs61996546 0.622 rs34660647 chr15:26841524 T/C cg14859324 chr15:26874363 GABRB3 -0.37 -5.05 -0.3 8.05e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs35955747 0.902 rs12166373 chr22:31700508 A/G cg25791279 chr22:32026902 PISD -0.48 -5.88 -0.34 1.25e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs60871478 0.853 rs62432864 chr7:808405 T/G cg05535760 chr7:792225 HEATR2 0.89 10.55 0.54 6.14e-22 Cerebrospinal P-tau181p levels; CESC trans rs561341 1.000 rs530209 chr17:30315287 A/G cg27661571 chr11:113659931 NA -0.83 -7.76 -0.43 1.9e-13 Hip circumference adjusted for BMI; CESC cis rs2735413 0.918 rs56397244 chr16:78081366 A/T cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7542091 0.635 rs7550733 chr1:210044968 G/A cg21951975 chr1:209979733 IRF6 0.47 8.25 0.45 7.51e-15 Monobrow; CESC cis rs4699052 0.662 rs6828151 chr4:104284756 C/G cg16532752 chr4:104119610 CENPE -0.37 -5.3 -0.31 2.46e-7 Testicular germ cell tumor; CESC cis rs962856 0.619 rs6546302 chr2:67605733 G/T cg09028215 chr2:67624308 ETAA1 -0.43 -5.25 -0.31 3.17e-7 Pancreatic cancer; CESC cis rs763121 0.853 rs5757211 chr22:39051705 C/T cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs8028182 0.636 rs4462560 chr15:75647964 G/C cg20655648 chr15:75932815 IMP3 -0.44 -5.6 -0.33 5.29e-8 Sudden cardiac arrest; CESC cis rs9788682 0.747 rs2568485 chr15:78752114 C/T cg24631222 chr15:78858424 CHRNA5 -0.64 -7.55 -0.42 7.09e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs3096299 0.933 rs3096297 chr16:89453155 T/G cg16743903 chr16:89593216 SPG7 -0.44 -5.55 -0.32 6.77e-8 Multiple myeloma (IgH translocation); CESC cis rs13102973 0.899 rs4479760 chr4:135867474 T/C cg14419869 chr4:135874104 NA 0.36 5.81 0.34 1.8e-8 Subjective well-being; CESC cis rs1577917 1.000 rs34281561 chr6:86701872 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -5.97 -0.34 7.47e-9 Response to antipsychotic treatment; CESC cis rs55871839 0.708 rs13263261 chr8:59814688 T/G cg07426533 chr8:59803705 TOX -0.51 -7.41 -0.41 1.71e-12 Pneumonia; CESC cis rs1371867 0.846 rs1660330 chr8:101305015 T/A cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.24e-11 Atrioventricular conduction; CESC cis rs8027181 0.839 rs7167076 chr15:73028873 G/A cg25632853 chr15:73088954 NA -0.31 -5.4 -0.31 1.51e-7 Triglyceride levels; CESC cis rs7208859 0.623 rs8079891 chr17:29058863 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2228479 0.850 rs17227263 chr16:89810598 G/A cg04013166 chr16:89971882 TCF25 0.77 6.69 0.38 1.32e-10 Skin colour saturation; CESC cis rs3749237 1.000 rs11130214 chr3:49735746 C/G cg03060546 chr3:49711283 APEH -0.64 -7.66 -0.43 3.42e-13 Resting heart rate; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00377757 chr17:76921538 TIMP2 -0.43 -6.1 -0.35 3.76e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7635838 0.822 rs9861633 chr3:11473437 C/G cg00170343 chr3:11313890 ATG7 0.43 5.71 0.33 3.03e-8 HDL cholesterol; CESC cis rs13031619 0.605 rs4849972 chr2:3698846 C/A cg25251562 chr2:3704773 ALLC 0.54 5.28 0.31 2.64e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs7818688 1.000 rs28363725 chr8:96027108 T/C cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs931812 0.895 rs4236763 chr8:101913022 G/A cg20993868 chr7:22813445 NA 0.5 6.99 0.39 2.23e-11 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs3768617 0.565 rs4233194 chr1:183060917 G/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.13 0.63 1.12e-30 Fuchs's corneal dystrophy; CESC cis rs16866061 1.000 rs72974219 chr2:225423784 G/C cg12698349 chr2:225449008 CUL3 0.75 11.51 0.58 4.07e-25 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs910316 0.967 rs10142770 chr14:75525449 G/A cg08847533 chr14:75593920 NEK9 1.01 18.87 0.76 6.3e-51 Height; CESC cis rs7940866 1.000 rs7940866 chr11:130817579 A/T cg12179176 chr11:130786555 SNX19 -0.56 -7.71 -0.43 2.57e-13 Schizophrenia; CESC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg05863683 chr7:1912471 MAD1L1 0.42 6.21 0.36 2.02e-9 Bipolar disorder and schizophrenia; CESC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg16325326 chr1:53192061 ZYG11B 0.9 15.66 0.69 1.42e-39 Monocyte count; CESC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg07747251 chr5:1868357 NA 0.36 6.13 0.35 3.19e-9 Cardiovascular disease risk factors; CESC cis rs3820928 1.000 rs978909 chr2:227771389 A/C cg11843606 chr2:227700838 RHBDD1 -0.44 -5.8 -0.34 1.87e-8 Pulmonary function; CESC cis rs1953600 1.000 rs2573346 chr10:81918041 G/A cg00277334 chr10:82204260 NA -0.48 -6.82 -0.39 6.16e-11 Sarcoidosis; CESC trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg15704280 chr7:45808275 SEPT13 -0.86 -13.88 -0.65 2.73e-33 Coronary artery disease; CESC cis rs6598955 0.670 rs10902734 chr1:26617923 G/T cg04990556 chr1:26633338 UBXN11 0.76 10.7 0.55 1.85e-22 Obesity-related traits; CESC cis rs6088590 1.000 rs6088595 chr20:33358499 T/A cg08999081 chr20:33150536 PIGU 0.59 8.69 0.47 3.73e-16 Coronary artery disease; CESC cis rs7937682 0.921 rs688354 chr11:111438762 A/G cg09085632 chr11:111637200 PPP2R1B -0.91 -13.02 -0.62 2.75e-30 Primary sclerosing cholangitis; CESC cis rs2011503 0.882 rs8108777 chr19:19359058 C/A cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.56 0.32 6.43e-8 Bipolar disorder; CESC cis rs9517313 0.707 rs9517298 chr13:99095003 C/T cg07423050 chr13:99094983 FARP1 -0.34 -6.23 -0.36 1.86e-9 Neuroticism; CESC cis rs13082711 0.911 rs4973772 chr3:27450234 G/T cg02860705 chr3:27208620 NA 0.59 7.39 0.41 1.94e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs62229266 0.804 rs62230788 chr21:37380337 A/T cg12218747 chr21:37451666 NA -0.41 -5.63 -0.33 4.55e-8 Mitral valve prolapse; CESC cis rs3749237 0.595 rs4855877 chr3:49448527 T/C cg06212747 chr3:49208901 KLHDC8B 0.53 7.21 0.4 5.87e-12 Resting heart rate; CESC cis rs727505 1.000 rs1541418 chr7:124448672 A/G cg23710748 chr7:124431027 NA -0.49 -7.84 -0.43 1.12e-13 Lewy body disease; CESC cis rs9487051 0.676 rs1829694 chr6:109593860 G/T cg21918786 chr6:109611834 NA -0.37 -5.41 -0.32 1.39e-7 Reticulocyte fraction of red cells; CESC cis rs2652822 0.935 rs12594313 chr15:63436662 A/G cg02713581 chr15:63449717 RPS27L 0.57 7.39 0.41 1.95e-12 Metabolic traits; CESC cis rs6964587 0.677 rs62467839 chr7:91967371 A/G cg17063962 chr7:91808500 NA 0.52 6.45 0.37 5.28e-10 Breast cancer; CESC cis rs1950626 0.577 rs61991118 chr14:101441974 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.69 9.23 0.49 8.76e-18 Pelvic organ prolapse (moderate/severe); CESC cis rs992157 0.835 rs6707559 chr2:219142773 C/T cg00012203 chr2:219082015 ARPC2 0.78 10.25 0.53 5.43e-21 Colorectal cancer; CESC cis rs854765 0.693 rs12941039 chr17:17765655 C/T cg04398451 chr17:18023971 MYO15A 0.63 9.0 0.48 4.56e-17 Total body bone mineral density; CESC cis rs1729951 0.575 rs10935213 chr3:136693459 A/G cg03617693 chr3:136751559 NA 0.39 5.45 0.32 1.13e-7 Neuroticism; CESC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg26839252 chr6:160211577 TCP1;MRPL18 0.49 6.15 0.35 2.83e-9 Age-related macular degeneration (geographic atrophy); CESC cis rs11871801 0.517 rs60929812 chr17:40759448 G/A cg16308533 chr17:40838983 CNTNAP1 0.39 5.12 0.3 5.95e-7 Crohn's disease; CESC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg05861140 chr6:150128134 PCMT1 -0.34 -5.04 -0.3 8.49e-7 Lung cancer; CESC cis rs11098499 0.754 rs17595608 chr4:120250506 C/T cg09307838 chr4:120376055 NA 0.77 10.45 0.54 1.22e-21 Corneal astigmatism; CESC cis rs7586879 0.616 rs6726199 chr2:25126328 G/C cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.02e-11 Body mass index; CESC cis rs7100689 0.784 rs1870142 chr10:82182296 G/A cg00277334 chr10:82204260 NA -0.61 -7.47 -0.42 1.19e-12 Post bronchodilator FEV1; CESC cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 6.36 0.36 8.73e-10 Personality dimensions; CESC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -5.87 -0.34 1.33e-8 Tonsillectomy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13762774 chr10:32048991 NA 0.48 6.28 0.36 1.38e-9 Gut microbiota (bacterial taxa); CESC cis rs9467711 0.606 rs12173854 chr6:26371679 A/G cg12826209 chr6:26865740 GUSBL1 0.62 5.24 0.31 3.25e-7 Autism spectrum disorder or schizophrenia; CESC trans rs561341 0.769 rs8074383 chr17:30178793 C/T cg20587970 chr11:113659929 NA 1.02 10.75 0.55 1.29e-22 Hip circumference adjusted for BMI; CESC cis rs7223966 1.000 rs11657306 chr17:61704822 G/A cg11494091 chr17:61959527 GH2 0.41 5.7 0.33 3.18e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg05564831 chr3:52568323 NT5DC2 0.44 6.69 0.38 1.3e-10 Bipolar disorder; CESC cis rs2404602 0.692 rs2137307 chr15:77149020 T/A cg26408565 chr15:76604113 ETFA -0.39 -5.68 -0.33 3.63e-8 Blood metabolite levels; CESC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg27170947 chr2:26402098 FAM59B -0.72 -8.31 -0.45 5.18e-15 Gut microbiome composition (summer); CESC cis rs6800768 0.633 rs826372 chr3:24163705 T/C cg10674438 chr3:24145617 LOC152024 -0.46 -6.73 -0.38 1.03e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09654908 chr15:62989952 TLN2 -0.56 -6.45 -0.37 5.19e-10 Gut microbiome composition (summer); CESC cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg27398817 chr8:82754497 SNX16 0.55 6.41 0.37 6.45e-10 Diastolic blood pressure; CESC cis rs12422267 0.536 rs58521339 chr12:132609486 T/C cg05134918 chr12:132603531 EP400NL -0.48 -5.08 -0.3 7.1e-7 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs965469 1.000 rs6051724 chr20:3279338 T/C cg25506879 chr20:3388711 C20orf194 -0.54 -5.88 -0.34 1.24e-8 IFN-related cytopenia; CESC cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg22875332 chr1:76189707 ACADM 0.66 7.84 0.43 1.1e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg02187348 chr16:89574699 SPG7 0.64 8.83 0.48 1.48e-16 Multiple myeloma (IgH translocation); CESC cis rs7666738 0.830 rs10007261 chr4:98926155 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg22903471 chr2:27725779 GCKR -0.55 -7.55 -0.42 6.9e-13 Total body bone mineral density; CESC cis rs9815354 0.761 rs57638657 chr3:41809238 G/C cg03022575 chr3:42003672 ULK4 0.68 6.06 0.35 4.7e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs4072980 0.524 rs28477803 chr1:38398694 C/T cg17077180 chr1:38461687 NA 0.43 6.18 0.36 2.38e-9 Coronary artery disease; CESC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg18446336 chr7:2847575 GNA12 -0.34 -5.4 -0.31 1.49e-7 Height; CESC cis rs67072384 1.000 rs72964198 chr11:72446464 C/T cg04827223 chr11:72435913 ARAP1 -0.71 -6.88 -0.39 4.23e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs6088580 0.634 rs1205345 chr20:32914699 A/G cg24642439 chr20:33292090 TP53INP2 -0.5 -6.58 -0.37 2.48e-10 Glomerular filtration rate (creatinine); CESC cis rs12497850 1.000 rs10865952 chr3:48744484 A/G cg03060546 chr3:49711283 APEH 0.43 5.35 0.31 1.91e-7 Parkinson's disease; CESC cis rs7078219 0.505 rs10883367 chr10:101287990 A/G cg09788492 chr10:101292477 NKX2-3 0.33 6.39 0.37 7.59e-10 Dental caries; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04902851 chr8:59572557 NSMAF -0.7 -8.47 -0.46 1.67e-15 Gut microbiome composition (summer); CESC cis rs9359856 0.623 rs7742602 chr6:90327385 A/G cg13799429 chr6:90582589 CASP8AP2 -0.55 -6.37 -0.36 8.29e-10 Bipolar disorder; CESC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg23982607 chr1:1823379 GNB1 -0.79 -12.31 -0.6 7.86e-28 Body mass index; CESC cis rs854765 0.927 rs12943914 chr17:17980671 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.4 5.08 0.3 7.27e-7 Total body bone mineral density; CESC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg13628971 chr7:2884303 GNA12 0.63 8.76 0.47 2.41e-16 Height; CESC cis rs453301 0.686 rs6601281 chr8:8911004 A/G cg06636001 chr8:8085503 FLJ10661 -0.42 -5.06 -0.3 7.94e-7 Joint mobility (Beighton score); CESC cis rs3105593 1.000 rs56069965 chr15:50966973 G/A cg08437265 chr15:50716283 USP8 0.46 6.07 0.35 4.49e-9 QT interval; CESC cis rs4132509 0.895 rs12045787 chr1:244011843 T/A cg21452805 chr1:244014465 NA 0.53 6.39 0.37 7.3e-10 RR interval (heart rate); CESC cis rs9811920 0.809 rs4928235 chr3:99706870 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.43 -5.49 -0.32 9.48e-8 Axial length; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08945467 chr1:58522070 DAB1 0.45 6.27 0.36 1.44e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs796364 0.806 rs10445791 chr2:201078307 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.75 -6.26 -0.36 1.58e-9 Schizophrenia; CESC cis rs7851660 0.967 rs7049054 chr9:100599969 T/G cg13688889 chr9:100608707 NA -0.68 -10.61 -0.55 3.8e-22 Strep throat; CESC cis rs6598955 0.670 rs3795685 chr1:26601385 A/G cg04990556 chr1:26633338 UBXN11 0.79 11.49 0.58 4.54e-25 Obesity-related traits; CESC cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.83 -12.15 -0.6 2.78e-27 Systemic lupus erythematosus; CESC cis rs34330 0.562 rs12229100 chr12:12865836 A/G cg04607235 chr12:12878440 APOLD1 0.83 9.25 0.49 7.77e-18 Systemic lupus erythematosus; CESC cis rs67311347 1.000 rs13095055 chr3:40505666 G/T cg09455208 chr3:40491958 NA -0.47 -8.04 -0.44 2.9e-14 Renal cell carcinoma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13995169 chr10:72142516 LRRC20 0.53 6.88 0.39 4.4e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs2530545 0.851 rs58859869 chr7:34692177 G/A cg14080982 chr15:71736038 THSD4 -0.48 -6.26 -0.36 1.53e-9 IgG glycosylation; CESC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs736801 0.704 rs56399423 chr5:131672657 T/C cg21138405 chr5:131827807 IRF1 -0.36 -5.15 -0.3 5.07e-7 Breast cancer;Mosquito bite size; CESC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg03709012 chr19:19516395 GATAD2A 1.01 16.06 0.7 5.36e-41 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04714248 chr16:27561727 GTF3C1;KIAA0556 -0.58 -6.87 -0.39 4.61e-11 Gut microbiome composition (summer); CESC cis rs738322 0.967 rs4383 chr22:38570927 C/G cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC cis rs7520050 0.751 rs2230657 chr1:46073489 G/A cg06784218 chr1:46089804 CCDC17 -0.34 -6.06 -0.35 4.6e-9 Red blood cell count;Reticulocyte count; CESC cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg03433033 chr1:76189801 ACADM 0.62 6.17 0.35 2.5e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9916302 0.571 rs28799952 chr17:37533056 C/T cg07936489 chr17:37558343 FBXL20 0.9 9.82 0.52 1.27e-19 Glomerular filtration rate (creatinine); CESC cis rs11583043 0.918 rs17525451 chr1:101422409 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.55 6.12 0.35 3.39e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg04248312 chr19:17393744 ANKLE1 -0.93 -15.26 -0.68 3.79e-38 Systemic lupus erythematosus; CESC cis rs6456156 0.586 rs9459862 chr6:167487011 A/G cg23791538 chr6:167370224 RNASET2 0.5 6.66 0.38 1.59e-10 Primary biliary cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16693212 chr11:108093249 ATM;NPAT -0.53 -6.29 -0.36 1.32e-9 Gut microbiome composition (summer); CESC cis rs6499255 1.000 rs55863174 chr16:69819996 G/C cg15192750 chr16:69999425 NA 0.46 5.64 0.33 4.46e-8 IgE levels; CESC cis rs3747547 0.534 rs11794104 chr9:38091723 T/C cg13774184 chr9:37916125 SHB -0.57 -5.1 -0.3 6.41e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs6957923 0.655 rs7781714 chr7:23593479 A/G cg20265043 chr7:23510089 IGF2BP3 0.41 5.11 0.3 6.03e-7 Height; CESC cis rs7408868 1.000 rs7245814 chr19:15274503 A/G cg14696996 chr19:15285081 NOTCH3 1.11 11.47 0.58 5.57e-25 Pulse pressure; CESC cis rs9768139 0.935 rs116290351 chr7:158119712 T/A cg06219351 chr7:158114137 PTPRN2 0.47 7.27 0.41 4.07e-12 Calcium levels; CESC cis rs7833986 0.501 rs2953901 chr8:56981824 C/A cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.16 0.3 4.9e-7 Height; CESC cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg05340658 chr4:99064831 C4orf37 0.79 12.12 0.6 3.52e-27 Colonoscopy-negative controls vs population controls; CESC cis rs10463316 0.744 rs6579869 chr5:150763621 G/A cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC trans rs208520 1.000 rs28773210 chr6:66993566 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.14 0.49 1.65e-17 Exhaled nitric oxide output; CESC cis rs1832871 0.672 rs9456289 chr6:158740347 G/A cg07165851 chr6:158734300 TULP4 0.59 6.4 0.37 7.02e-10 Height; CESC trans rs61931739 0.517 rs7313663 chr12:34417058 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.75e-12 Morning vs. evening chronotype; CESC cis rs7639513 0.767 rs9861472 chr3:12707776 A/T cg23032965 chr3:12705835 RAF1 -0.8 -11.46 -0.58 6.01e-25 Itch intensity from mosquito bite; CESC cis rs7940866 0.903 rs1820353 chr11:130870765 A/G cg12179176 chr11:130786555 SNX19 0.64 9.2 0.49 1.13e-17 Schizophrenia; CESC cis rs7520050 0.966 rs6675946 chr1:46371774 G/T cg03146154 chr1:46216737 IPP -0.48 -6.19 -0.36 2.33e-9 Red blood cell count;Reticulocyte count; CESC cis rs6426558 0.537 rs56219094 chr1:227340191 T/C cg10327440 chr1:227177885 CDC42BPA -0.47 -5.85 -0.34 1.48e-8 Neutrophil percentage of white cells; CESC cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg03433033 chr1:76189801 ACADM 0.62 5.93 0.34 9.18e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs651907 0.557 rs12629658 chr3:101356535 A/G cg12386194 chr3:101231763 SENP7 0.44 5.4 0.31 1.51e-7 Colorectal cancer; CESC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg02475777 chr4:1388615 CRIPAK 0.74 9.22 0.49 9.67e-18 Longevity; CESC trans rs9650657 0.562 rs10090444 chr8:10745469 C/G cg15556689 chr8:8085844 FLJ10661 0.59 7.33 0.41 2.73e-12 Neuroticism; CESC cis rs735396 0.595 rs2258287 chr12:121454313 G/T cg25281562 chr12:121454272 C12orf43 0.53 6.95 0.39 2.9e-11 N-glycan levels; CESC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg04518342 chr5:131593106 PDLIM4 0.35 5.06 0.3 7.79e-7 Breast cancer; CESC cis rs7115242 0.800 rs10736487 chr11:116950232 A/G cg01368799 chr11:117014884 PAFAH1B2 0.67 5.82 0.34 1.71e-8 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs3796352 1.000 rs71301814 chr3:53117663 G/A cg12962167 chr3:53033115 SFMBT1 0.67 5.87 0.34 1.29e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg27297192 chr10:134578999 INPP5A 0.42 5.75 0.33 2.39e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg22105103 chr4:187893119 NA 0.48 6.91 0.39 3.67e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs3820068 0.603 rs67349836 chr1:15966176 T/C cg16988262 chr1:15930761 NA 0.32 5.13 0.3 5.66e-7 Systolic blood pressure; CESC cis rs4835473 0.932 rs17694797 chr4:144699965 T/C cg25736465 chr4:144833511 NA -0.33 -5.23 -0.31 3.48e-7 Immature fraction of reticulocytes; CESC cis rs2279817 0.735 rs12067869 chr1:17989765 G/T cg21791023 chr1:18019539 ARHGEF10L -0.56 -7.36 -0.41 2.38e-12 Neuroticism; CESC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg19482086 chr6:160211437 TCP1;MRPL18 0.77 11.06 0.56 1.26e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs10949834 0.529 rs150861 chr7:73524901 T/C cg07137043 chr7:73588983 EIF4H 0.64 7.58 0.42 5.84e-13 Verbal memory performance (residualized delayed recall change); CESC cis rs589448 0.902 rs642786 chr12:69758462 T/C cg20891283 chr12:69753455 YEATS4 0.98 16.88 0.72 6.73e-44 Cerebrospinal fluid biomarker levels; CESC cis rs17826219 0.714 rs11650821 chr17:28968150 T/C cg19761014 chr17:28927070 LRRC37B2 0.86 6.49 0.37 4.09e-10 Body mass index; CESC trans rs11039798 0.841 rs7950737 chr11:48590678 T/G cg15704280 chr7:45808275 SEPT13 0.66 6.21 0.36 2.01e-9 Axial length; CESC cis rs9902453 0.780 rs62068621 chr17:28170382 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.39 0.46 2.99e-15 Coffee consumption (cups per day); CESC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg18099408 chr3:52552593 STAB1 -0.34 -5.77 -0.33 2.17e-8 Bipolar disorder; CESC cis rs611744 0.647 rs674391 chr8:109242803 A/T cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.66e-8 Dupuytren's disease; CESC cis rs9916302 0.904 rs11867312 chr17:37597748 C/T cg15445000 chr17:37608096 MED1 0.41 6.74 0.38 9.67e-11 Glomerular filtration rate (creatinine); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27613860 chr2:30369571 YPEL5 0.46 6.39 0.37 7.53e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs365132 0.934 rs251844 chr5:176476605 T/A cg16309518 chr5:176445507 NA -0.43 -6.3 -0.36 1.24e-9 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs7772486 0.790 rs7753833 chr6:146161432 C/A cg23711669 chr6:146136114 FBXO30 0.89 13.01 0.62 2.86e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs2880765 0.835 rs6496027 chr15:86049988 C/T cg10818794 chr15:86012489 AKAP13 -0.34 -5.19 -0.3 4.25e-7 Coronary artery disease; CESC cis rs4604732 0.631 rs34443739 chr1:247626913 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.45 0.32 1.17e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg12365402 chr11:9010492 NRIP3 -0.32 -5.26 -0.31 3e-7 Hemoglobin concentration; CESC trans rs61931739 0.500 rs56056630 chr12:34543465 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.74e-12 Morning vs. evening chronotype; CESC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg18876405 chr7:65276391 NA 0.54 7.18 0.4 6.97e-12 Aortic root size; CESC cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.84e-27 Colonoscopy-negative controls vs population controls; CESC cis rs4474465 0.850 rs7942371 chr11:78219975 A/G cg27205649 chr11:78285834 NARS2 0.44 5.28 0.31 2.69e-7 Alzheimer's disease (survival time); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg15065069 chr1:154974120 ZBTB7B 0.5 6.06 0.35 4.69e-9 Thyroid stimulating hormone; CESC cis rs654950 0.806 rs7550496 chr1:42043834 G/A cg06885757 chr1:42089581 HIVEP3 0.63 10.21 0.53 7.69e-21 Airway imaging phenotypes; CESC cis rs1153858 0.725 rs74572151 chr15:45647526 T/G cg14582100 chr15:45693742 SPATA5L1 0.44 6.25 0.36 1.61e-9 Homoarginine levels; CESC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.54 -0.32 7.14e-8 Electroencephalogram traits; CESC cis rs7584330 0.657 rs10211024 chr2:238353776 A/T cg14458575 chr2:238380390 NA 0.57 8.15 0.45 1.42e-14 Prostate cancer; CESC cis rs10463316 0.894 rs1876619 chr5:150744773 G/C cg03212797 chr5:150827313 SLC36A1 -0.51 -6.64 -0.38 1.79e-10 Metabolite levels (Pyroglutamine); CESC cis rs35110281 0.837 rs2838343 chr21:45078035 C/T cg01579765 chr21:45077557 HSF2BP -0.56 -9.55 -0.51 9.17e-19 Mean corpuscular volume; CESC cis rs7089973 0.604 rs11196941 chr10:116596258 A/G cg23260525 chr10:116636907 FAM160B1 0.4 7.38 0.41 2.02e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg05313129 chr8:58192883 C8orf71 -0.5 -5.05 -0.3 8.06e-7 Developmental language disorder (linguistic errors); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13530817 chr7:72951610 BCL7B 0.47 6.59 0.38 2.3e-10 Fibrinogen levels; CESC cis rs7520050 0.933 rs6666743 chr1:46311275 C/T cg24296786 chr1:45957014 TESK2 0.42 5.42 0.32 1.33e-7 Red blood cell count;Reticulocyte count; CESC cis rs710216 0.917 rs1681859 chr1:43411829 G/A cg03128534 chr1:43423976 SLC2A1 0.56 6.28 0.36 1.38e-9 Red cell distribution width; CESC cis rs3008870 0.755 rs1535365 chr1:67497613 T/C cg02640540 chr1:67518911 SLC35D1 0.44 5.36 0.31 1.84e-7 Lymphocyte percentage of white cells; CESC cis rs1215050 0.791 rs7434393 chr4:98768576 T/C cg05340658 chr4:99064831 C4orf37 0.53 7.03 0.4 1.75e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs644799 1.000 rs487609 chr11:95588102 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.68 8.41 0.46 2.59e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9457247 1.000 rs4710147 chr6:167374239 G/A cg23791538 chr6:167370224 RNASET2 0.6 8.47 0.46 1.73e-15 Crohn's disease; CESC cis rs1801251 1.000 rs6717841 chr2:233590255 C/T cg08000102 chr2:233561755 GIGYF2 0.69 9.56 0.51 8.52e-19 Coronary artery disease; CESC cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg15017067 chr4:17643749 FAM184B 0.36 5.05 0.3 8.11e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs17253792 0.822 rs79262019 chr14:56092704 A/G cg01858014 chr14:56050164 KTN1 -0.83 -7.03 -0.4 1.7e-11 Putamen volume; CESC cis rs4144743 0.759 rs34251886 chr17:45320299 G/T cg18085866 chr17:45331354 ITGB3 -0.62 -5.53 -0.32 7.54e-8 Body mass index; CESC cis rs34638657 0.732 rs12597171 chr16:82200119 A/G cg09439754 chr16:82129088 HSD17B2 0.38 6.42 0.37 6.11e-10 Lung adenocarcinoma; CESC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg07930192 chr7:1003750 NA 0.42 5.79 0.34 1.96e-8 Longevity;Endometriosis; CESC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs11098499 0.865 rs28845498 chr4:120405186 G/A cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.1e-8 Corneal astigmatism; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13481374 chr9:34318769 KIF24 -0.42 -6.07 -0.35 4.38e-9 Systemic lupus erythematosus; CESC cis rs4523957 0.928 rs11657644 chr17:2175210 C/G cg16513277 chr17:2031491 SMG6 -0.58 -7.64 -0.42 3.93e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7000551 0.689 rs2122878 chr8:22311916 T/C cg12081754 chr8:22256438 SLC39A14 0.4 5.15 0.3 5.07e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg00149659 chr3:10157352 C3orf10 0.74 9.17 0.49 1.36e-17 Alzheimer's disease; CESC cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg22875332 chr1:76189707 ACADM 0.66 7.95 0.44 5.45e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6120849 0.663 rs11698868 chr20:33549946 C/T cg06115741 chr20:33292138 TP53INP2 0.53 5.04 0.3 8.81e-7 Protein C levels; CESC cis rs7772486 0.875 rs854148 chr6:146310979 G/C cg05347473 chr6:146136440 FBXO30 0.56 7.37 0.41 2.14e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2576037 0.796 rs2571020 chr18:44584189 A/T cg19077165 chr18:44547161 KATNAL2 0.53 7.36 0.41 2.29e-12 Personality dimensions; CESC cis rs1568889 0.838 rs7131379 chr11:28085789 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.5 0.64 5.83e-32 Bipolar disorder; CESC cis rs3768617 0.510 rs6424888 chr1:183085696 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.81 -12.68 -0.61 4e-29 Fuchs's corneal dystrophy; CESC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg03806693 chr22:41940476 POLR3H -1.23 -14.8 -0.67 1.54e-36 Vitiligo; CESC cis rs2425143 1.000 rs6060643 chr20:34449851 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.69 0.33 3.4e-8 Blood protein levels; CESC cis rs1800469 1.000 rs2241714 chr19:41869392 C/T cg09537434 chr19:41945824 ATP5SL 0.63 7.74 0.43 2.12e-13 Colorectal cancer; CESC cis rs17641971 0.599 rs818555 chr8:49999211 A/G cg00325661 chr8:49890786 NA -0.48 -6.81 -0.39 6.59e-11 Blood metabolite levels; CESC cis rs854765 0.718 rs7224815 chr17:17845800 A/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.42 5.17 0.3 4.66e-7 Total body bone mineral density; CESC cis rs6502050 0.830 rs7219036 chr17:80161119 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.53 -0.37 3.39e-10 Life satisfaction; CESC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg14926445 chr8:58193284 C8orf71 -0.49 -5.29 -0.31 2.6e-7 Developmental language disorder (linguistic errors); CESC cis rs796364 0.806 rs1509832 chr2:200874443 G/T cg23649088 chr2:200775458 C2orf69 0.6 5.44 0.32 1.23e-7 Schizophrenia; CESC cis rs561341 1.000 rs521919 chr17:30298039 G/T cg00745463 chr17:30367425 LRRC37B -0.68 -6.71 -0.38 1.19e-10 Hip circumference adjusted for BMI; CESC cis rs12618769 0.625 rs72819982 chr2:99043337 A/G cg10123293 chr2:99228465 UNC50 0.38 5.04 0.3 8.52e-7 Bipolar disorder; CESC cis rs7809950 1.000 rs10251808 chr7:107120453 G/A cg23024343 chr7:107201750 COG5 -0.44 -6.2 -0.36 2.11e-9 Coronary artery disease; CESC cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg17366294 chr4:99064904 C4orf37 0.57 7.93 0.44 6.16e-14 Colonoscopy-negative controls vs population controls; CESC cis rs16854884 0.710 rs1867607 chr3:143809274 T/C cg06585982 chr3:143692056 C3orf58 0.47 6.15 0.35 2.83e-9 Economic and political preferences (feminism/equality); CESC trans rs4942242 0.663 rs9525816 chr13:44223898 A/G cg19169023 chr15:41853346 TYRO3 -0.59 -7.22 -0.41 5.54e-12 Response to tocilizumab in rheumatoid arthritis; CESC cis rs8177179 1.000 rs8177179 chr3:133463457 G/A cg18769074 chr3:133464867 TF 0.3 5.75 0.33 2.42e-8 Iron status biomarkers (transferrin levels); CESC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg27165867 chr14:105738592 BRF1 -0.55 -6.17 -0.35 2.55e-9 Mean platelet volume;Platelet distribution width; CESC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.63 0.64 2.09e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9467773 0.620 rs3800303 chr6:26598188 A/G cg24633756 chr6:26577808 NA 0.38 5.76 0.33 2.33e-8 Intelligence (multi-trait analysis); CESC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg26354017 chr1:205819088 PM20D1 -0.75 -10.0 -0.52 3.59e-20 Menarche (age at onset); CESC cis rs75477785 0.590 rs72649913 chr1:210077087 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.96 6.81 0.39 6.53e-11 Cleft lip with or without cleft palate; CESC cis rs7179456 0.544 rs2555357 chr15:59087115 A/G cg05156742 chr15:59063176 FAM63B 0.78 11.22 0.57 3.54e-24 Asperger disorder; CESC cis rs116095464 0.510 rs7723883 chr5:270798 T/C cg22496380 chr5:211416 CCDC127 -0.73 -8.42 -0.46 2.47e-15 Breast cancer; CESC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg19592336 chr6:28129416 ZNF389 0.48 7.09 0.4 1.19e-11 Cardiac Troponin-T levels; CESC cis rs9467711 0.606 rs67509210 chr6:26354100 G/T cg12826209 chr6:26865740 GUSBL1 0.62 5.31 0.31 2.36e-7 Autism spectrum disorder or schizophrenia; CESC cis rs17253792 0.730 rs77079997 chr14:56155250 A/G cg01858014 chr14:56050164 KTN1 -0.82 -6.79 -0.39 7.15e-11 Putamen volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10821925 chr12:29533733 ERGIC2 -0.46 -6.09 -0.35 3.89e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.32 -5.29 -0.31 2.55e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg12463550 chr7:65579703 CRCP 0.56 6.93 0.39 3.29e-11 Aortic root size; CESC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07067085 chr12:120638762 RPLP0 0.57 6.68 0.38 1.37e-10 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16109817 chr1:16162209 FLJ37453 -0.45 -6.35 -0.36 9.42e-10 Gut microbiota (bacterial taxa); CESC cis rs2425143 1.000 rs2425078 chr20:34298163 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.95 0.34 8.42e-9 Blood protein levels; CESC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg22535103 chr8:58192502 C8orf71 -0.92 -10.13 -0.53 1.3e-20 Developmental language disorder (linguistic errors); CESC cis rs2204008 0.807 rs12816136 chr12:38456037 A/G cg13010199 chr12:38710504 ALG10B -0.43 -5.57 -0.32 6.22e-8 Bladder cancer; CESC cis rs7264396 0.563 rs2050729 chr20:34294409 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.89 10.7 0.55 1.88e-22 Total cholesterol levels; CESC cis rs941408 0.515 rs4624312 chr19:2774460 T/C cg06609049 chr19:2785107 THOP1 0.96 14.86 0.67 9.75e-37 Total cholesterol levels; CESC cis rs7224737 1.000 rs11079034 chr17:40288890 G/A cg20291162 chr17:40259547 DHX58 -0.41 -5.57 -0.32 6.12e-8 Fibrinogen levels; CESC trans rs7902708 0.920 rs12268596 chr10:54421876 G/A cg26219051 chr22:43739629 SCUBE1 -0.48 -6.08 -0.35 4.13e-9 Bone properties (heel); CESC cis rs9479482 1.000 rs9478354 chr6:150334366 G/A cg03788504 chr6:150331562 NA -0.4 -7.64 -0.42 4.07e-13 Alopecia areata; CESC cis rs6570726 0.846 rs870491 chr6:145933390 T/G cg05347473 chr6:146136440 FBXO30 0.5 6.57 0.37 2.6e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs992157 0.835 rs4674282 chr2:219144230 A/T cg00012203 chr2:219082015 ARPC2 -0.73 -9.38 -0.5 3.16e-18 Colorectal cancer; CESC cis rs7267979 0.789 rs6083810 chr20:25329759 T/A cg24626310 chr20:25276739 ABHD12;PYGB -0.7 -11.59 -0.58 2.18e-25 Liver enzyme levels (alkaline phosphatase); CESC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg21770322 chr7:97807741 LMTK2 0.54 8.13 0.45 1.67e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg11764359 chr7:65958608 NA -0.68 -8.81 -0.48 1.68e-16 Aortic root size; CESC cis rs2011503 0.769 rs72999059 chr19:19378245 A/C cg11584989 chr19:19387371 SF4 0.63 7.58 0.42 5.75e-13 Bipolar disorder; CESC cis rs4803468 1.000 rs10853751 chr19:41903220 G/A cg14132834 chr19:41945861 ATP5SL -0.65 -8.13 -0.45 1.69e-14 Height; CESC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg00074818 chr8:8560427 CLDN23 0.36 5.24 0.31 3.32e-7 Obesity-related traits; CESC cis rs901683 1.000 rs35750365 chr10:46013143 A/G cg16031567 chr10:46195673 NA -0.81 -5.4 -0.32 1.45e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs5753618 0.583 rs5749279 chr22:31854209 A/G cg00478049 chr22:31556069 RNF185 -0.41 -5.21 -0.3 3.82e-7 Colorectal cancer; CESC cis rs3126085 0.935 rs11204952 chr1:152227321 G/A cg03465714 chr1:152285911 FLG -0.42 -5.19 -0.3 4.2e-7 Atopic dermatitis; CESC cis rs9549367 0.789 rs57747440 chr13:113894750 C/A cg18105134 chr13:113819100 PROZ -0.66 -7.97 -0.44 4.85e-14 Platelet distribution width; CESC cis rs1538970 0.962 rs4660849 chr1:45819872 A/G cg03146154 chr1:46216737 IPP -0.45 -5.39 -0.31 1.54e-7 Platelet count; CESC cis rs9815354 0.812 rs73071358 chr3:41830487 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg00166722 chr3:10149974 C3orf24 0.49 6.08 0.35 4.1e-9 Alzheimer's disease; CESC cis rs1344694 0.566 rs13029765 chr2:216894976 A/T cg25588852 chr2:216877276 MREG -0.35 -5.69 -0.33 3.33e-8 Alcohol dependence; CESC cis rs10733682 0.524 rs10987418 chr9:129462563 A/G cg00232160 chr9:129468157 NA 0.41 6.58 0.37 2.45e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.44 -0.32 1.24e-7 Total body bone mineral density; CESC trans rs958685 0.716 rs765871 chr2:70708357 T/C cg20996124 chr1:1144203 NA -0.41 -6.07 -0.35 4.5e-9 Hand grip strength; CESC cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg19077165 chr18:44547161 KATNAL2 -0.52 -7.67 -0.43 3.35e-13 Personality dimensions; CESC cis rs6500602 0.727 rs10451135 chr16:4580214 T/C cg08645402 chr16:4508243 NA 0.51 8.34 0.46 4.21e-15 Schizophrenia; CESC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.61 6.89 0.39 3.99e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7130144 0.686 rs7936714 chr11:130434295 T/C cg26307797 chr11:130446613 NA -0.59 -5.42 -0.32 1.31e-7 Urate levels in lean individuals; CESC cis rs9951602 0.920 rs3859334 chr18:76684193 G/A cg00806245 chr18:76673096 NA -0.53 -6.11 -0.35 3.58e-9 Obesity-related traits; CESC cis rs10781543 0.839 rs6560632 chr9:139371786 A/C cg14019695 chr9:139328340 INPP5E 0.38 5.77 0.33 2.19e-8 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12683467 chr3:197686956 IQCG;LMLN 0.59 6.18 0.35 2.36e-9 Gut microbiome composition (summer); CESC cis rs1153858 1.000 rs66714503 chr15:45648038 G/C cg21132104 chr15:45694354 SPATA5L1 0.84 11.4 0.57 9.5e-25 Homoarginine levels; CESC cis rs9300255 0.679 rs28583837 chr12:123863620 G/A cg00376283 chr12:123451042 ABCB9 -0.58 -5.97 -0.34 7.65e-9 Neutrophil percentage of white cells; CESC cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.45 0.42 1.34e-12 Tonsillectomy; CESC cis rs854765 0.724 rs2955371 chr17:17967397 G/A cg04398451 chr17:18023971 MYO15A 0.69 9.97 0.52 4.48e-20 Total body bone mineral density; CESC cis rs5758659 1.000 rs134873 chr22:42657566 T/G cg04733989 chr22:42467013 NAGA 0.42 5.74 0.33 2.52e-8 Cognitive function; CESC cis rs6500602 0.627 rs1641866 chr16:4593040 A/C cg08645402 chr16:4508243 NA 0.46 6.87 0.39 4.45e-11 Schizophrenia; CESC cis rs4481887 0.927 rs6587445 chr1:248440915 A/G cg00666640 chr1:248458726 OR2T12 0.39 6.6 0.38 2.23e-10 Common traits (Other); CESC cis rs4865169 0.783 rs7668814 chr4:57825190 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.59 0.42 5.47e-13 Breast cancer; CESC cis rs9915657 0.870 rs759499 chr17:70133177 C/T cg09344028 chr17:70110421 NA 0.33 5.85 0.34 1.41e-8 Thyroid hormone levels; CESC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg21963583 chr11:68658836 MRPL21 0.43 5.85 0.34 1.43e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9875589 0.957 rs62234598 chr3:13964610 G/A cg19554555 chr3:13937349 NA 0.53 6.68 0.38 1.36e-10 Ovarian reserve; CESC cis rs2721195 0.719 rs4925812 chr8:145808035 C/T cg26752003 chr8:145688521 CYHR1 -0.43 -5.5 -0.32 8.8e-8 Age at first birth; CESC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg23758822 chr17:41437982 NA 1.05 16.21 0.71 1.53e-41 Menopause (age at onset); CESC cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.43 -5.38 -0.31 1.64e-7 Tonsillectomy; CESC trans rs7827545 0.545 rs1867062 chr8:135559079 G/A cg24633756 chr6:26577808 NA -0.53 -6.05 -0.35 5e-9 Hypertension (SNP x SNP interaction); CESC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 12.2 0.6 1.79e-27 Alzheimer's disease; CESC cis rs12410462 0.582 rs2872251 chr1:227647723 G/A cg04117972 chr1:227635322 NA 0.62 6.0 0.35 6.56e-9 Major depressive disorder; CESC cis rs7188697 0.922 rs37034 chr16:58551360 C/G cg21335942 chr16:58549945 SETD6 0.46 5.41 0.32 1.44e-7 QT interval; CESC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg23708337 chr7:1209742 NA 0.54 5.38 0.31 1.61e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg07092213 chr7:1199455 ZFAND2A -0.5 -5.71 -0.33 3.07e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg23583168 chr7:148888333 NA -0.74 -10.66 -0.55 2.51e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6032067 0.777 rs80323300 chr20:43785287 T/C cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.64 5.48 0.32 9.84e-8 Depression; CESC cis rs6460942 1.000 rs117657017 chr7:12318891 T/C cg06484146 chr7:12443880 VWDE -0.81 -8.78 -0.47 2.13e-16 Coronary artery disease; CESC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg17949981 chr6:28129498 ZNF389 0.44 5.49 0.32 9.34e-8 Depression; CESC cis rs2952156 1.000 rs2952156 chr17:37876835 A/G cg00129232 chr17:37814104 STARD3 -0.68 -8.52 -0.46 1.25e-15 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27026005 chr19:50380748 TBC1D17;AKT1S1 0.55 6.3 0.36 1.26e-9 Gut microbiome composition (summer); CESC cis rs56104184 1.000 rs56104184 chr19:49370310 C/T cg15549821 chr19:49342101 PLEKHA4 -0.56 -6.57 -0.37 2.68e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs5769765 0.825 rs9616780 chr22:50292763 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.2 -0.3 4.01e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09256617 chr11:44587148 CD82 0.57 6.62 0.38 1.99e-10 Gut microbiome composition (summer); CESC trans rs453301 0.571 rs330054 chr8:9088291 G/A cg06636001 chr8:8085503 FLJ10661 -0.53 -6.82 -0.39 6.1e-11 Joint mobility (Beighton score); CESC cis rs9611565 1.000 rs5751086 chr22:41768862 C/T cg17376030 chr22:41985996 PMM1 0.5 6.17 0.35 2.52e-9 Vitiligo; CESC cis rs11252926 0.537 rs61836851 chr10:447231 T/C cg18196295 chr10:418757 DIP2C 0.52 7.01 0.4 2.01e-11 Psychosis in Alzheimer's disease; CESC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg06108461 chr20:60628389 TAF4 -0.92 -14.01 -0.65 9.73e-34 Body mass index; CESC cis rs10861342 1.000 rs10861357 chr12:105544254 C/T cg23923672 chr12:105501055 KIAA1033 0.73 5.51 0.32 8.58e-8 IgG glycosylation; CESC cis rs826838 0.935 rs1684406 chr12:39127265 A/G cg26384229 chr12:38710491 ALG10B -0.67 -10.95 -0.56 2.81e-23 Heart rate; CESC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4722166 0.630 rs1581497 chr7:22779503 C/A cg26061582 chr7:22766209 IL6 0.51 5.55 0.32 6.82e-8 Lung cancer; CESC cis rs11098499 0.754 rs1511017 chr4:120250805 G/A cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23506964 chr4:56413211 CLOCK 0.55 6.1 0.35 3.7e-9 Gut microbiome composition (summer); CESC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg10295955 chr4:187884368 NA -1.04 -21.25 -0.79 3.44e-59 Lobe attachment (rater-scored or self-reported); CESC cis rs6499129 0.558 rs13334205 chr16:67581883 A/G cg26727032 chr16:67993705 SLC12A4 -0.61 -7.42 -0.41 1.56e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs116095464 0.558 rs61689490 chr5:224904 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.65 0.33 4.24e-8 Breast cancer; CESC cis rs7512552 0.839 rs11581351 chr1:150440200 G/C cg15654264 chr1:150340011 RPRD2 0.39 5.1 0.3 6.55e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg21782813 chr7:2030301 MAD1L1 0.53 7.68 0.43 2.99e-13 Bipolar disorder and schizophrenia; CESC cis rs67311347 1.000 rs954589 chr3:40444545 C/T cg09455208 chr3:40491958 NA 0.5 8.28 0.45 6.1e-15 Renal cell carcinoma; CESC cis rs617219 0.889 rs1664551 chr5:78440096 C/T cg22188827 chr5:78429774 NA -0.42 -5.05 -0.3 8.28e-7 Betaine levels in individuals undergoing cardiac evaluation; CESC cis rs12136530 0.625 rs61334679 chr1:19754993 G/A cg01832549 chr1:19774989 CAPZB -0.5 -6.59 -0.38 2.39e-10 Lead levels in blood; CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08180459 chr4:100870737 LOC256880;H2AFZ -0.58 -6.51 -0.37 3.77e-10 Gut microbiome composition (summer); CESC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg05132306 chr1:1846340 CALML6 -0.3 -6.37 -0.36 8.4e-10 Body mass index; CESC cis rs4835473 0.897 rs11727223 chr4:144628243 C/T cg25736465 chr4:144833511 NA 0.43 6.62 0.38 1.95e-10 Immature fraction of reticulocytes; CESC cis rs6062302 0.549 rs4809586 chr20:62249402 C/T cg09650180 chr20:62225654 GMEB2 -0.82 -9.32 -0.5 4.63e-18 Glioblastoma; CESC cis rs12930096 0.878 rs12917676 chr16:11680268 A/G cg07439791 chr16:11680400 LITAF 0.66 6.06 0.35 4.76e-9 QT interval; CESC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg24562669 chr7:97807699 LMTK2 -0.49 -7.06 -0.4 1.49e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg10792982 chr14:105748885 BRF1 0.42 5.33 0.31 2.11e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7599312 0.532 rs1531788 chr2:213394320 C/T cg20637307 chr2:213403960 ERBB4 0.39 5.42 0.32 1.34e-7 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7264396 0.580 rs6119655 chr20:34412049 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.28 0.41 3.81e-12 Total cholesterol levels; CESC cis rs533581 0.866 rs2968474 chr16:88970566 A/G cg16701003 chr16:89028210 CBFA2T3 -0.49 -6.7 -0.38 1.23e-10 Social autistic-like traits; CESC cis rs12476592 0.602 rs1255 chr2:63825934 T/C cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC cis rs854765 0.547 rs9913277 chr17:17919749 G/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.57 7.61 0.42 4.9e-13 Total body bone mineral density; CESC cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg13298116 chr11:62369859 EML3;MTA2 0.66 9.93 0.52 5.83e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7216064 0.954 rs4790974 chr17:65951107 A/T cg07042672 chr17:66097459 LOC651250 0.62 7.67 0.43 3.21e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7828089 0.582 rs7825938 chr8:22266866 G/A cg23129673 chr8:22266227 SLC39A14 0.36 5.39 0.31 1.56e-7 Verbal declarative memory; CESC cis rs9309473 1.000 rs6756987 chr2:73687077 G/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.18 -0.36 2.36e-9 Metabolite levels; CESC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg22903471 chr2:27725779 GCKR -0.52 -7.3 -0.41 3.33e-12 Total body bone mineral density; CESC cis rs920590 0.721 rs61180388 chr8:19670214 G/C cg03894339 chr8:19674705 INTS10 0.68 7.77 0.43 1.72e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs752010 0.619 rs7539238 chr1:42113572 A/C cg06885757 chr1:42089581 HIVEP3 0.62 9.75 0.51 2.22e-19 Lupus nephritis in systemic lupus erythematosus; CESC cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg14784868 chr12:69753453 YEATS4 0.6 8.56 0.47 9.5e-16 Blood protein levels; CESC cis rs3008870 0.755 rs10789219 chr1:67417742 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.63 8.38 0.46 3.04e-15 Lymphocyte percentage of white cells; CESC cis rs9623117 0.915 rs7290587 chr22:40482752 G/A cg05033341 chr22:40419857 FAM83F -0.47 -5.28 -0.31 2.67e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs561341 1.000 rs56903735 chr17:30254393 T/A cg12193833 chr17:30244370 NA -0.61 -6.12 -0.35 3.31e-9 Hip circumference adjusted for BMI; CESC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg23758822 chr17:41437982 NA 1.0 14.95 0.68 4.7e-37 Menopause (age at onset); CESC cis rs4812048 0.793 rs6070693 chr20:57589516 C/T cg14073986 chr20:57617431 SLMO2 0.73 5.8 0.34 1.92e-8 Mean platelet volume; CESC cis rs977987 0.778 rs11858992 chr16:75411445 A/C cg03315344 chr16:75512273 CHST6 0.4 5.74 0.33 2.65e-8 Dupuytren's disease; CESC cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg11752832 chr7:134001865 SLC35B4 0.54 7.09 0.4 1.19e-11 Mean platelet volume; CESC cis rs7914558 0.966 rs2065977 chr10:104729415 C/T cg08650961 chr10:104748594 CNNM2 0.31 5.05 0.3 8.15e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1144333 1.000 rs76192904 chr1:76359995 C/T cg10523679 chr1:76189770 ACADM 0.62 5.93 0.34 9.62e-9 Attention function in attention deficit hyperactive disorder; CESC cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg21573476 chr21:45109991 RRP1B 0.53 7.91 0.44 7.05e-14 Mean corpuscular volume; CESC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs208520 0.526 rs6455072 chr6:66797215 A/G cg07460842 chr6:66804631 NA -1.11 -27.05 -0.86 3.36e-78 Exhaled nitric oxide output; CESC cis rs40363 0.720 rs4453493 chr16:3533881 T/C cg22508957 chr16:3507546 NAT15 -0.53 -7.83 -0.43 1.17e-13 Tuberculosis; CESC cis rs79349575 0.721 rs4794004 chr17:47038471 C/T cg16584676 chr17:46985605 UBE2Z 0.47 5.88 0.34 1.26e-8 Type 2 diabetes; CESC cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg22834771 chr12:69754056 YEATS4 0.55 7.38 0.41 2.08e-12 Cerebrospinal fluid biomarker levels; CESC trans rs9393777 0.920 rs13191227 chr6:27390115 G/C cg06606381 chr12:133084897 FBRSL1 -1.12 -8.34 -0.46 4.21e-15 Intelligence (multi-trait analysis); CESC cis rs9443189 0.703 rs2748950 chr6:76442985 A/G cg01950844 chr6:76311363 SENP6 -0.61 -6.83 -0.39 5.64e-11 Prostate cancer; CESC cis rs3820928 0.874 rs10166456 chr2:227900113 G/A cg05526886 chr2:227700861 RHBDD1 -0.44 -5.59 -0.32 5.74e-8 Pulmonary function; CESC cis rs8062405 0.754 rs149299 chr16:28485141 T/C cg08761264 chr16:28874980 SH2B1 -0.44 -5.22 -0.31 3.59e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06751603 chr19:11152063 SMARCA4 0.51 6.69 0.38 1.29e-10 Fibrinogen levels; CESC cis rs2243480 1.000 rs313799 chr7:65494330 A/G cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC cis rs4141404 0.787 rs11913992 chr22:31585220 G/A cg13145458 chr22:31556086 RNF185 0.48 6.03 0.35 5.34e-9 Paclitaxel-induced neuropathy; CESC cis rs8077577 0.895 rs16960996 chr17:18110559 A/G cg16794390 chr17:18148240 FLII 0.41 5.64 0.33 4.37e-8 Obesity-related traits; CESC cis rs9814567 1.000 rs6769885 chr3:134286913 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.1 -0.35 3.7e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1511802 0.666 rs6835646 chr4:187123519 T/C cg24794857 chr4:187113578 CYP4V2 0.47 5.87 0.34 1.32e-8 Blood protein levels; CESC cis rs116095464 1.000 rs7723693 chr5:306032 G/A cg22857025 chr5:266934 NA -1.15 -9.5 -0.5 1.31e-18 Breast cancer; CESC trans rs1908814 0.516 rs11250178 chr8:11800234 A/C cg15556689 chr8:8085844 FLJ10661 0.52 6.52 0.37 3.57e-10 Neuroticism; CESC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.72 5.99 0.35 6.66e-9 Platelet count; CESC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs1728785 0.901 rs698711 chr16:68561955 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.23 0.41 5.24e-12 Ulcerative colitis; CESC cis rs6582630 0.555 rs11181657 chr12:38381858 T/C cg13010199 chr12:38710504 ALG10B -0.46 -5.95 -0.34 8.29e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg06808227 chr14:105710500 BRF1 -0.54 -6.05 -0.35 4.99e-9 Mean platelet volume;Platelet distribution width; CESC cis rs8111998 0.625 rs57665772 chr19:22764877 A/G cg19914732 chr19:22715077 NA -0.37 -5.09 -0.3 6.68e-7 Corneal structure; CESC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg18337363 chr3:52569053 NT5DC2 0.29 5.03 0.3 8.89e-7 Bipolar disorder; CESC trans rs7839040 0.698 rs13282879 chr8:82928431 A/G cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.18 0.53 9.01e-21 Mean platelet volume; CESC cis rs2070677 0.668 rs7899159 chr10:135431451 C/T cg20169779 chr10:135381914 SYCE1 -0.75 -8.81 -0.48 1.65e-16 Gout; CESC cis rs7000551 0.751 rs2469755 chr8:22360212 G/A cg12081754 chr8:22256438 SLC39A14 0.39 5.22 0.31 3.7e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs6089584 0.528 rs881994 chr20:60623931 G/A cg24733560 chr20:60626293 TAF4 0.48 7.12 0.4 1.01e-11 Body mass index; CESC cis rs3816788 0.620 rs11783414 chr8:21773384 A/G cg17168535 chr8:21777572 XPO7 -0.6 -9.18 -0.49 1.29e-17 Lung cancer in ever smokers; CESC cis rs28374715 0.609 rs8043237 chr15:41514298 G/A cg18705301 chr15:41695430 NDUFAF1 -0.81 -10.3 -0.53 3.78e-21 Ulcerative colitis; CESC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg02034447 chr16:89574710 SPG7 0.46 5.81 0.34 1.79e-8 Multiple myeloma (IgH translocation); CESC cis rs9486719 0.843 rs2499787 chr6:96841762 G/C cg06623918 chr6:96969491 KIAA0776 0.81 7.49 0.42 9.97e-13 Migraine;Coronary artery disease; CESC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6088590 1.000 rs6119512 chr20:33306904 T/C cg24642439 chr20:33292090 TP53INP2 0.85 11.75 0.59 5.97e-26 Coronary artery disease; CESC cis rs6460942 0.908 rs78374554 chr7:12242285 G/A cg06484146 chr7:12443880 VWDE -0.67 -6.56 -0.37 2.76e-10 Coronary artery disease; CESC cis rs2749592 0.918 rs1208653 chr10:38253826 C/G cg25427524 chr10:38739819 LOC399744 0.5 6.48 0.37 4.4e-10 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs11098499 0.691 rs9307471 chr4:120261262 G/A cg09307838 chr4:120376055 NA 0.76 10.31 0.54 3.54e-21 Corneal astigmatism; CESC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg26338869 chr17:61819248 STRADA 0.65 8.51 0.46 1.28e-15 Prudent dietary pattern; CESC cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg02487422 chr3:49467188 NICN1 0.44 5.57 0.32 6.38e-8 Parkinson's disease; CESC cis rs78707713 0.512 rs12772559 chr10:71184356 C/G cg12610070 chr10:71211762 TSPAN15 -0.33 -7.09 -0.4 1.21e-11 Venous thromboembolism; CESC cis rs2425143 0.730 rs2095819 chr20:34353278 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.72 6.67 0.38 1.52e-10 Blood protein levels; CESC cis rs2228479 0.702 rs62053702 chr16:89860688 G/T cg04013166 chr16:89971882 TCF25 0.77 6.61 0.38 2.05e-10 Skin colour saturation; CESC cis rs2408955 0.521 rs10875749 chr12:48531917 T/A cg24011408 chr12:48396354 COL2A1 -0.5 -7.61 -0.42 4.79e-13 Glycated hemoglobin levels; CESC cis rs10484885 0.775 rs17584945 chr6:90512776 T/C cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.12 -0.4 1.02e-11 QRS interval (sulfonylurea treatment interaction); CESC trans rs61931739 0.500 rs11053277 chr12:34553835 T/A cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.74e-12 Morning vs. evening chronotype; CESC trans rs3942852 0.696 rs4597030 chr11:48176573 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -8.67 -0.47 4.34e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg07697082 chr8:82753677 SNX16 0.38 5.74 0.33 2.55e-8 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16584020 chr19:3573832 HMG20B 0.54 5.99 0.35 6.7e-9 Gut microbiome composition (summer); CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg16145915 chr7:1198662 ZFAND2A -0.54 -6.8 -0.39 6.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7605827 0.866 rs6752546 chr2:15630729 T/C cg19274914 chr2:15703543 NA 0.38 6.74 0.38 9.95e-11 Educational attainment (years of education); CESC cis rs7191439 0.858 rs6500489 chr16:88772046 T/C cg27087555 chr16:88793112 FAM38A -1.25 -8.68 -0.47 4.03e-16 Plateletcrit; CESC trans rs7927771 1.000 rs11039255 chr11:47495746 G/T cg22986597 chr11:65341001 FAM89B -0.41 -6.18 -0.35 2.46e-9 Subjective well-being; CESC cis rs1538970 0.924 rs7528573 chr1:45913860 T/C cg05343316 chr1:45956843 TESK2 0.89 12.04 0.59 6.22e-27 Platelet count; CESC cis rs5750830 0.594 rs6001568 chr22:39775786 G/A cg05872129 chr22:39784769 NA -0.84 -11.47 -0.58 5.43e-25 Intelligence (multi-trait analysis); CESC cis rs9911578 0.813 rs8066773 chr17:56601552 A/G cg05425664 chr17:57184151 TRIM37 -0.44 -5.61 -0.33 5.2100000000000003e-08 Intelligence (multi-trait analysis); CESC cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg14784868 chr12:69753453 YEATS4 0.92 14.62 0.67 7.03e-36 Cerebrospinal fluid biomarker levels; CESC cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg25019033 chr10:957182 NA -0.65 -8.4 -0.46 2.8e-15 Eosinophil percentage of granulocytes; CESC cis rs7259376 0.936 rs6511344 chr19:22535673 C/T cg02657401 chr19:22469223 NA -0.26 -5.05 -0.3 8.29e-7 Menopause (age at onset); CESC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 5.87 0.34 1.32e-8 Total body bone mineral density; CESC cis rs7084402 0.967 rs1658421 chr10:60331928 A/T cg07615347 chr10:60278583 BICC1 0.59 9.15 0.49 1.57e-17 Refractive error; CESC cis rs8180040 0.966 rs922957 chr3:47422152 G/C cg27129171 chr3:47204927 SETD2 -0.63 -9.81 -0.52 1.42e-19 Colorectal cancer; CESC cis rs3857067 0.736 rs2865333 chr4:95019964 A/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs9929218 0.953 rs3118227 chr16:68734855 G/A cg02972257 chr16:68554789 NA 0.59 6.7 0.38 1.24e-10 Colorectal cancer; CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg09033563 chr22:24373618 LOC391322 -0.45 -5.82 -0.34 1.68e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg23711669 chr6:146136114 FBXO30 0.93 12.36 0.6 5.18e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg23161317 chr6:28129485 ZNF389 0.47 5.89 0.34 1.18e-8 Depression; CESC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.28 -0.36 1.34e-9 Total body bone mineral density; CESC cis rs921968 0.541 rs3770214 chr2:219508988 C/T cg02176678 chr2:219576539 TTLL4 -0.53 -8.74 -0.47 2.76e-16 Mean corpuscular hemoglobin concentration; CESC cis rs2997447 0.761 rs17184891 chr1:26447557 A/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.17 0.3 4.68e-7 QRS complex (12-leadsum); CESC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg26338869 chr17:61819248 STRADA 0.62 7.74 0.43 2.06e-13 Prudent dietary pattern; CESC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg24977027 chr2:88469347 THNSL2 -0.45 -6.09 -0.35 3.93e-9 Response to metformin (IC50); CESC cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg01579765 chr21:45077557 HSF2BP -0.54 -9.07 -0.49 2.67e-17 Mean corpuscular volume; CESC cis rs9486719 0.843 rs2499793 chr6:96846402 A/C cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC cis rs6502050 0.835 rs4789724 chr17:80150546 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.48 -0.37 4.56e-10 Life satisfaction; CESC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg06600287 chr1:53387719 ECHDC2 -0.29 -5.06 -0.3 7.72e-7 Monocyte count; CESC cis rs11252926 0.673 rs10795161 chr10:497748 G/T cg03684893 chr10:554711 DIP2C -0.37 -5.75 -0.33 2.4e-8 Psychosis in Alzheimer's disease; CESC cis rs977987 0.806 rs7204984 chr16:75475520 G/C cg03315344 chr16:75512273 CHST6 0.43 6.11 0.35 3.53e-9 Dupuytren's disease; CESC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg00750074 chr16:89608354 SPG7 -0.42 -6.18 -0.35 2.41e-9 Multiple myeloma (IgH translocation); CESC cis rs1941023 0.584 rs4938941 chr11:60173360 C/T cg08716584 chr11:60157161 MS4A7 0.53 8.54 0.46 1.09e-15 Congenital heart disease (maternal effect); CESC cis rs548181 0.736 rs540723 chr11:125489621 A/G cg03464685 chr11:125439445 EI24 0.91 8.01 0.44 3.76e-14 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00399650 chr7:141402322 KIAA1147 0.46 6.28 0.36 1.42e-9 Systemic lupus erythematosus; CESC cis rs4718428 0.705 rs12536410 chr7:66254290 G/A cg12165864 chr7:66369176 NA -0.65 -7.35 -0.41 2.52e-12 Corneal structure; CESC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg13206674 chr6:150067644 NUP43 0.43 6.05 0.35 4.94e-9 Lung cancer; CESC cis rs7584330 0.518 rs7585975 chr2:238439089 G/A cg14458575 chr2:238380390 NA 0.6 5.91 0.34 1.07e-8 Prostate cancer; CESC cis rs8060686 0.545 rs117751972 chr16:68171968 C/T cg26727032 chr16:67993705 SLC12A4 -0.5 -5.45 -0.32 1.16e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg17724175 chr1:150552817 MCL1 0.4 6.28 0.36 1.4e-9 Melanoma; CESC cis rs2073300 0.793 rs75758241 chr20:23434696 A/G cg12062639 chr20:23401060 NAPB 0.64 5.07 0.3 7.46e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg18904891 chr8:8559673 CLDN23 0.73 8.39 0.46 2.86e-15 Obesity-related traits; CESC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs6963495 0.556 rs711427 chr7:105161755 T/G cg19920283 chr7:105172520 RINT1 0.54 6.28 0.36 1.35e-9 Bipolar disorder (body mass index interaction); CESC cis rs113835537 0.627 rs11227534 chr11:66336171 C/A cg22134325 chr11:66188745 NPAS4 0.37 5.52 0.32 7.98e-8 Airway imaging phenotypes; CESC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg03352830 chr11:487213 PTDSS2 0.67 6.75 0.38 9.33e-11 Body mass index; CESC cis rs561341 0.883 rs72821942 chr17:30234460 C/T cg00745463 chr17:30367425 LRRC37B -0.63 -6.18 -0.36 2.36e-9 Hip circumference adjusted for BMI; CESC cis rs2835872 0.758 rs1709821 chr21:39035622 T/C cg06728970 chr21:39037746 KCNJ6 0.3 5.51 0.32 8.67e-8 Electroencephalographic traits in alcoholism; CESC cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.76e-28 Colonoscopy-negative controls vs population controls; CESC cis rs3106136 0.527 rs2632410 chr4:95149507 A/T cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Capecitabine sensitivity; CESC cis rs7845219 0.544 rs34208552 chr8:95908067 C/G cg16049864 chr8:95962084 TP53INP1 -0.5 -7.32 -0.41 3.04e-12 Type 2 diabetes; CESC cis rs763121 0.853 rs5757208 chr22:39049230 A/C cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.54e-7 Menopause (age at onset); CESC cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg02487422 chr3:49467188 NICN1 0.46 5.81 0.34 1.82e-8 Parkinson's disease; CESC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg06873352 chr17:61820015 STRADA 0.47 6.81 0.39 6.42e-11 Height; CESC cis rs6088590 0.523 rs6058084 chr20:33183804 C/T cg08999081 chr20:33150536 PIGU 0.7 12.11 0.6 3.66e-27 Coronary artery disease; CESC cis rs7927771 0.524 rs10838746 chr11:47706291 A/G cg20307385 chr11:47447363 PSMC3 0.61 8.46 0.46 1.87e-15 Subjective well-being; CESC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg25036284 chr2:26402008 FAM59B 0.82 8.54 0.46 1.06e-15 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04637597 chr2:201754183 NIF3L1;PPIL3 0.6 6.32 0.36 1.08e-9 Gut microbiome composition (summer); CESC cis rs2236918 0.710 rs2488470 chr1:242019580 A/G cg17736920 chr1:242011382 EXO1 0.55 6.92 0.39 3.37e-11 Menopause (age at onset); CESC cis rs4808199 0.895 rs2163805 chr19:19575945 G/A cg03709012 chr19:19516395 GATAD2A 1.17 13.38 0.63 1.53e-31 Nonalcoholic fatty liver disease; CESC cis rs1023500 0.505 rs134886 chr22:42673856 C/T cg05082376 chr22:42548792 NA 0.38 5.69 0.33 3.41e-8 Schizophrenia; CESC cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg03467027 chr4:99064603 C4orf37 0.42 5.29 0.31 2.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1538970 0.816 rs34673142 chr1:45985561 G/A cg06784218 chr1:46089804 CCDC17 0.36 5.7 0.33 3.12e-8 Platelet count; CESC cis rs67478160 0.643 rs11624184 chr14:104240998 A/G cg08213375 chr14:104286397 PPP1R13B 0.45 9.04 0.49 3.46e-17 Schizophrenia; CESC cis rs62283056 0.512 rs752854 chr4:6281961 C/T cg14416269 chr4:6271139 WFS1 0.43 6.11 0.35 3.59e-9 Cisplatin-induced ototoxicity; CESC cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg03060546 chr3:49711283 APEH 0.45 5.63 0.33 4.66e-8 Parkinson's disease; CESC cis rs798766 0.779 rs3134866 chr4:1723265 A/G cg07041428 chr4:1763019 NA -0.39 -5.56 -0.32 6.66e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs4253772 0.701 rs9627280 chr22:46643964 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.57 6.67 0.38 1.45e-10 LDL cholesterol;Cholesterol, total; CESC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg13628971 chr7:2884303 GNA12 0.64 8.46 0.46 1.82e-15 Height; CESC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg11235426 chr6:292522 DUSP22 -0.73 -9.79 -0.52 1.62e-19 Menopause (age at onset); CESC cis rs763121 0.785 rs6001203 chr22:39099602 T/C cg21395723 chr22:39101663 GTPBP1 0.49 6.67 0.38 1.5e-10 Menopause (age at onset); CESC cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg15605315 chr1:45957053 TESK2 0.42 5.38 0.31 1.67e-7 High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19064601 chr11:68142605 LRP5 -0.55 -6.33 -0.36 1.06e-9 Gut microbiome composition (summer); CESC cis rs7000551 0.779 rs2443507 chr8:22373231 G/A cg12081754 chr8:22256438 SLC39A14 0.45 6.1 0.35 3.71e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs718433 0.584 rs1569292 chr14:22216993 G/A cg02257791 chr14:22217085 NA -0.33 -5.13 -0.3 5.64e-7 Intraocular pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06831761 chr7:104885108 SRPK2 -0.64 -7.55 -0.42 7.23e-13 Gut microbiome composition (summer); CESC cis rs7116495 0.609 rs7113520 chr11:71691946 G/A cg18441811 chr11:71824068 C11orf51 -0.82 -5.21 -0.31 3.71e-7 Severe influenza A (H1N1) infection; CESC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg11764359 chr7:65958608 NA 0.67 8.72 0.47 3.12e-16 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27261837 chr1:146714163 CHD1L 0.53 7.01 0.4 1.93e-11 Gut microbiota (bacterial taxa); CESC cis rs11203032 0.901 rs4074851 chr10:90958618 A/G cg16672925 chr10:90967113 CH25H -0.66 -6.72 -0.38 1.12e-10 Heart failure; CESC cis rs3820928 0.839 rs58580037 chr2:227876274 G/T cg11843606 chr2:227700838 RHBDD1 -0.48 -6.13 -0.35 3.13e-9 Pulmonary function; CESC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs2710642 0.566 rs2710651 chr2:63166379 G/A cg17519650 chr2:63277830 OTX1 0.58 8.01 0.44 3.55e-14 LDL cholesterol levels;LDL cholesterol; CESC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg22920501 chr2:26401640 FAM59B -0.66 -7.9 -0.44 7.42e-14 Gut microbiome composition (summer); CESC cis rs7520050 0.966 rs4660321 chr1:46366760 A/G cg24296786 chr1:45957014 TESK2 0.44 5.55 0.32 7.05e-8 Red blood cell count;Reticulocyte count; CESC cis rs10489202 0.657 rs201541 chr1:167992344 T/A cg24449463 chr1:168025552 DCAF6 -0.42 -5.3 -0.31 2.4e-7 Schizophrenia; CESC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg16405210 chr4:1374714 KIAA1530 0.77 10.47 0.54 1.04e-21 Obesity-related traits; CESC cis rs2795502 0.882 rs2744091 chr10:43339441 A/G cg27426351 chr10:43362370 NA -0.44 -5.48 -0.32 9.96e-8 Blood protein levels; CESC cis rs116095464 0.558 rs62347677 chr5:227453 A/G cg10591111 chr5:226296 SDHA -0.55 -6.84 -0.39 5.44e-11 Breast cancer; CESC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg03452623 chr4:187889614 NA -0.89 -16.06 -0.7 5.23e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs476633 0.691 rs6492997 chr15:41541171 G/A cg20272979 chr15:41787780 ITPKA 0.38 5.64 0.33 4.37e-8 Glomerular filtration rate (creatinine); CESC cis rs7103648 0.695 rs12223593 chr11:47789082 T/G cg20307385 chr11:47447363 PSMC3 0.8 12.17 0.6 2.22e-27 Diastolic blood pressure;Systolic blood pressure; CESC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 13.13 0.63 1.15e-30 Platelet count; CESC cis rs12478296 1.000 rs7603984 chr2:243047294 A/G cg06360820 chr2:242988706 NA -0.92 -9.02 -0.48 3.81e-17 Obesity-related traits; CESC trans rs11039798 1.000 rs10160423 chr11:48457227 G/T cg15704280 chr7:45808275 SEPT13 0.69 6.58 0.37 2.56e-10 Axial length; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg08309023 chr2:148839265 NA 0.42 6.4 0.37 7.09e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs425277 0.585 rs3107143 chr1:2045372 G/C cg19257562 chr1:2043853 PRKCZ 0.38 6.38 0.37 7.7e-10 Height; CESC cis rs4568518 0.740 rs12699927 chr7:18011752 A/T cg03009463 chr7:17980271 SNX13 0.44 5.9 0.34 1.08e-8 Measles; CESC cis rs3806843 0.771 rs2563336 chr5:140107199 A/G cg16179182 chr5:140090404 VTRNA1-1 0.42 5.51 0.32 8.6e-8 Depressive symptoms (multi-trait analysis); CESC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg11843238 chr5:131593191 PDLIM4 0.36 5.18 0.3 4.41e-7 Breast cancer; CESC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg22535103 chr8:58192502 C8orf71 -0.9 -8.99 -0.48 4.95e-17 Developmental language disorder (linguistic errors); CESC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg21285383 chr16:89894308 SPIRE2 -0.35 -6.28 -0.36 1.35e-9 Vitiligo; CESC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg15782153 chr7:917662 C7orf20 0.51 5.58 0.32 6.04e-8 Cerebrospinal P-tau181p levels; CESC cis rs9790314 1.000 rs7647327 chr3:161016421 T/C cg04691961 chr3:161091175 C3orf57 -0.44 -5.73 -0.33 2.74e-8 Morning vs. evening chronotype; CESC cis rs9611565 0.559 rs4822049 chr22:41993496 G/A cg06634786 chr22:41940651 POLR3H -0.67 -6.46 -0.37 4.85e-10 Vitiligo; CESC trans rs2727020 0.734 rs1164663 chr11:49294723 A/T cg03929089 chr4:120376271 NA 0.69 8.55 0.46 9.62e-16 Coronary artery disease; CESC cis rs10979 1.000 rs1416206 chr6:143889385 T/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs9902453 0.933 rs9898353 chr17:28451865 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.6 0.42 5.23e-13 Coffee consumption (cups per day); CESC cis rs4629710 0.534 rs6916881 chr6:131565153 C/T cg12606694 chr6:131520996 AKAP7 0.48 5.83 0.34 1.62e-8 Multiple myeloma (IgH translocation); CESC cis rs2777491 0.957 rs2015781 chr15:41648967 C/G cg02330683 chr15:41787940 ITPKA 0.43 6.32 0.36 1.08e-9 Ulcerative colitis; CESC cis rs6964587 0.869 rs6979024 chr7:91481512 T/C cg17063962 chr7:91808500 NA -0.5 -6.6 -0.38 2.22e-10 Breast cancer; CESC cis rs977987 0.771 rs12929673 chr16:75470295 C/T cg03315344 chr16:75512273 CHST6 0.42 6.12 0.35 3.38e-9 Dupuytren's disease; CESC cis rs11997175 1.000 rs7838577 chr8:33760802 A/G ch.8.33884649F chr8:33765107 NA 0.67 8.59 0.47 7.79e-16 Body mass index; CESC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg17178900 chr1:205818956 PM20D1 0.79 12.63 0.61 6.05e-29 Menarche (age at onset); CESC cis rs2012796 0.785 rs61986597 chr14:81853107 T/C cg02996355 chr14:81879375 NA 0.66 8.38 0.46 3.05e-15 Night sleep phenotypes; CESC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.01 0.56 1.86e-23 Alzheimer's disease; CESC cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg22455342 chr2:225449267 CUL3 0.69 8.96 0.48 5.92e-17 IgE levels in asthmatics (D.p. specific); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06096994 chr13:41635664 WBP4 -0.42 -6.08 -0.35 4.24e-9 Fibrinogen levels; CESC cis rs2066819 1.000 rs111885088 chr12:56657216 A/C cg26714650 chr12:56694279 CS -1.43 -10.45 -0.54 1.24e-21 Psoriasis vulgaris; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18195498 chr7:100281506 GIGYF1 0.56 8.04 0.44 2.95e-14 Fibrinogen levels; CESC cis rs10129255 0.500 rs8022547 chr14:107190222 A/T cg23076370 chr14:107095027 NA -0.65 -9.79 -0.52 1.6e-19 Kawasaki disease; CESC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs7481584 0.624 rs377765 chr11:3046298 C/T cg25174290 chr11:3078921 CARS -0.45 -6.3 -0.36 1.21e-9 Calcium levels; CESC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs6694270 0.529 rs12041777 chr1:19109193 T/C cg19637330 chr1:19110922 NA -0.53 -6.39 -0.37 7.37e-10 Drug-induced liver injury (nitrofurantoin); CESC cis rs1475718 0.563 rs1041608 chr9:137116205 C/T cg21243944 chr9:137118148 NA -0.35 -5.1 -0.3 6.45e-7 Immature fraction of reticulocytes;Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg17366294 chr4:99064904 C4orf37 0.55 7.47 0.42 1.15e-12 Colonoscopy-negative controls vs population controls; CESC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg07677032 chr17:61819896 STRADA 0.43 5.46 0.32 1.09e-7 Height; CESC cis rs4803468 1.000 rs284655 chr19:41928765 C/T cg09537434 chr19:41945824 ATP5SL -1.1 -20.31 -0.78 5.82e-56 Height; CESC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg07700843 chr1:2391317 NA -0.49 -9.44 -0.5 2.08e-18 Schizophrenia; CESC cis rs17376456 0.877 rs28539612 chr5:93499099 C/T cg25358565 chr5:93447407 FAM172A 1.17 10.95 0.56 2.93e-23 Diabetic retinopathy; CESC cis rs734999 0.545 rs10797436 chr1:2538349 G/A cg20673091 chr1:2541236 MMEL1 0.45 7.53 0.42 8.1e-13 Ulcerative colitis; CESC cis rs13392177 0.660 rs62185964 chr2:219073745 A/G cg00012203 chr2:219082015 ARPC2 -0.66 -8.2 -0.45 1.01e-14 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg11764359 chr7:65958608 NA -0.73 -10.48 -0.54 1.01e-21 Aortic root size; CESC cis rs1348850 0.561 rs57986285 chr2:178468663 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 5.32 0.31 2.19e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs26868 0.766 rs30995 chr16:2248017 C/T cg07587117 chr16:2239488 CASKIN1 -0.32 -5.23 -0.31 3.41e-7 Height; CESC cis rs2797160 1.000 rs1832980 chr6:125997444 T/G cg05901451 chr6:126070800 HEY2 -0.45 -6.66 -0.38 1.55e-10 Endometrial cancer; CESC cis rs11048434 0.736 rs11048190 chr12:9104939 C/T cg23795048 chr12:9217529 LOC144571 0.37 5.76 0.33 2.38e-8 Sjögren's syndrome; CESC cis rs2247341 1.000 rs34049648 chr4:1697337 G/A cg07465881 chr4:1713556 SLBP -0.53 -6.83 -0.39 5.78e-11 Hip circumference adjusted for BMI;Height; CESC cis rs9888739 1.000 rs9940397 chr16:31303201 T/C cg15817542 chr16:31343056 ITGAM -0.45 -5.39 -0.31 1.56e-7 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19274820 chr6:41863130 USP49 0.54 6.08 0.35 4.14e-9 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs5750671 chr22:39094619 A/C cg06022373 chr22:39101656 GTPBP1 0.94 17.4 0.73 9.39e-46 Menopause (age at onset); CESC trans rs9354308 0.899 rs2802057 chr6:66548093 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 6.62 0.38 1.93e-10 Metabolite levels; CESC trans rs28735056 0.609 rs4799099 chr18:77639585 A/G cg05926928 chr17:57297772 GDPD1 0.61 7.61 0.42 4.91e-13 Schizophrenia; CESC cis rs1153858 0.621 rs1719237 chr15:45579822 G/A cg14582100 chr15:45693742 SPATA5L1 0.4 5.37 0.31 1.72e-7 Homoarginine levels; CESC cis rs2024825 1 rs2024825 chr1:67597977 T/C cg17031739 chr1:67600172 NA 0.55 6.1 0.35 3.68e-9 Leprosy; CESC cis rs9640161 0.830 rs36069544 chr7:150061538 G/A cg17279839 chr7:150038598 RARRES2 0.44 5.57 0.32 6.27e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs34779708 0.966 rs1545757 chr10:35445588 A/T cg03585969 chr10:35415529 CREM 0.77 10.24 0.53 6.08e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs9309473 0.950 rs17009149 chr2:73790368 T/C cg20560298 chr2:73613845 ALMS1 -0.53 -6.86 -0.39 4.91e-11 Metabolite levels; CESC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg25767906 chr1:53392781 SCP2 -0.51 -7.09 -0.4 1.22e-11 Monocyte count; CESC cis rs16867335 0.625 rs7573877 chr2:181478111 A/G cg23363182 chr2:181467187 NA -0.4 -6.11 -0.35 3.49e-9 Survival in rectal cancer; CESC cis rs7474896 0.515 rs662928 chr10:38316216 G/T cg00409905 chr10:38381863 ZNF37A 0.46 5.15 0.3 5.06e-7 Obesity (extreme); CESC cis rs6121246 0.909 rs1994251 chr20:30287328 T/G cg13852791 chr20:30311386 BCL2L1 0.78 8.17 0.45 1.24e-14 Mean corpuscular hemoglobin; CESC cis rs9834373 0.821 rs13314576 chr3:78485637 T/C cg06138941 chr3:78371609 NA -0.42 -5.14 -0.3 5.43e-7 Protein quantitative trait loci; CESC cis rs8111998 0.826 rs59838183 chr19:22766434 G/A cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs4662945 0.525 rs10174479 chr2:130296287 A/C cg05962382 chr2:130345044 NA -0.5 -7.68 -0.43 3.16e-13 Response to cytidine analogues (gemcitabine); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05373286 chr10:76969678 VDAC2 0.46 6.24 0.36 1.73e-9 Gut microbiota (bacterial taxa); CESC cis rs4268898 0.722 rs4665253 chr2:24382546 G/A cg06627628 chr2:24431161 ITSN2 0.52 6.77 0.38 8.5e-11 Asthma; CESC cis rs6460942 0.597 rs13232817 chr7:12551909 C/A cg20607287 chr7:12443886 VWDE -0.72 -7.3 -0.41 3.43e-12 Coronary artery disease; CESC cis rs8077889 0.917 rs72836545 chr17:41892602 A/G cg26893861 chr17:41843967 DUSP3 0.82 9.8 0.52 1.55e-19 Triglycerides; CESC cis rs11098499 0.954 rs6846442 chr4:120326323 G/A cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs7666738 0.830 rs921523 chr4:98841659 C/T cg05340658 chr4:99064831 C4orf37 0.7 9.96 0.52 4.58e-20 Colonoscopy-negative controls vs population controls; CESC cis rs7085104 0.572 rs284857 chr10:104574063 C/T cg23093090 chr10:104574429 C10orf26 0.34 5.39 0.31 1.53e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs11997175 0.624 rs4733460 chr8:33675169 T/C ch.8.33884649F chr8:33765107 NA 0.57 7.31 0.41 3.1e-12 Body mass index; CESC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8067545 0.611 rs7222984 chr17:20019694 A/C cg13482628 chr17:19912719 NA 0.4 5.29 0.31 2.52e-7 Schizophrenia; CESC cis rs796364 0.664 rs3106089 chr2:200884615 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.84 7.64 0.42 3.96e-13 Schizophrenia; CESC cis rs73206853 0.619 rs112148402 chr12:111171493 T/C cg04375036 chr12:111181819 PPP1CC -0.64 -5.11 -0.3 6.21e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs763121 0.853 rs4821809 chr22:39065743 G/C cg21395723 chr22:39101663 GTPBP1 0.42 5.27 0.31 2.86e-7 Menopause (age at onset); CESC cis rs66561647 1.000 rs66561647 chr8:128971861 C/T cg05480350 chr8:128972681 MIR1205;PVT1 0.58 8.12 0.45 1.77e-14 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02352107 chr15:76603736 ETFA 0.62 7.47 0.42 1.17e-12 Gut microbiome composition (summer); CESC cis rs672059 1.000 rs672119 chr1:183162506 G/A ch.1.3577855R chr1:183094577 LAMC1 0.55 7.16 0.4 7.77e-12 Hypertriglyceridemia; CESC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.61 -0.33 4.97e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg14664628 chr15:75095509 CSK -0.53 -6.96 -0.39 2.6e-11 Breast cancer; CESC cis rs34779708 0.931 rs11010082 chr10:35351155 A/G cg03585969 chr10:35415529 CREM 0.78 10.17 0.53 1.03e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs72945132 0.714 rs115143889 chr11:70150122 G/T cg14191688 chr11:70257035 CTTN 0.47 5.65 0.33 4.1e-8 Coronary artery disease; CESC cis rs1185460 0.967 rs1784459 chr11:118938388 C/A cg23280166 chr11:118938394 VPS11 0.58 8.12 0.45 1.77e-14 Coronary artery disease; CESC cis rs3008870 0.755 rs1024229 chr1:67512903 G/T cg02640540 chr1:67518911 SLC35D1 0.71 9.16 0.49 1.46e-17 Lymphocyte percentage of white cells; CESC cis rs12586317 0.576 rs6571696 chr14:35630175 A/G cg16230307 chr14:35515116 FAM177A1 0.41 5.15 0.3 5.03e-7 Psoriasis; CESC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg20243544 chr17:37824526 PNMT 0.46 5.75 0.33 2.52e-8 Glomerular filtration rate (creatinine); CESC cis rs3820068 0.705 rs927206 chr1:15893338 C/T cg17385448 chr1:15911702 AGMAT 0.36 5.55 0.32 6.93e-8 Systolic blood pressure; CESC cis rs7666738 0.546 rs17546687 chr4:98769266 T/A cg17366294 chr4:99064904 C4orf37 0.5 6.16 0.35 2.71e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9902453 1.000 rs60967688 chr17:28437052 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.73 0.43 2.28e-13 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18052984 chr12:51158439 ATF1 0.6 7.24 0.41 4.81e-12 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06622468 chr19:10491460 TYK2 -0.44 -6.22 -0.36 1.93e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9902453 0.899 rs8067580 chr17:28471248 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 8.02 0.44 3.41e-14 Coffee consumption (cups per day); CESC trans rs4671386 0.901 rs7578291 chr2:60522662 T/C cg24386296 chr4:1723849 TMEM129;TACC3 0.51 6.52 0.37 3.54e-10 Acne (severe); CESC cis rs7267979 0.718 rs2983489 chr20:25244120 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.08 0.65 5.37e-34 Liver enzyme levels (alkaline phosphatase); CESC cis rs4253772 0.591 rs11705624 chr22:46685380 C/T cg24881330 chr22:46731750 TRMU 0.75 5.43 0.32 1.25e-7 LDL cholesterol;Cholesterol, total; CESC cis rs12476592 0.602 rs989527 chr2:63726791 G/T cg17519650 chr2:63277830 OTX1 -0.47 -5.4 -0.31 1.46e-7 Childhood ear infection; CESC trans rs1814175 0.645 rs11040661 chr11:49952146 G/T cg03929089 chr4:120376271 NA -0.89 -14.87 -0.67 8.52e-37 Height; CESC cis rs9457247 0.967 rs387733 chr6:167409771 C/T cg25258033 chr6:167368657 RNASET2 -0.4 -5.92 -0.34 9.71e-9 Crohn's disease; CESC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs10911232 0.507 rs4575047 chr1:182976028 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05926606 chr21:40685342 BRWD1 0.63 7.15 0.4 8.21e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24385632 chr11:16838615 PLEKHA7 -0.56 -6.11 -0.35 3.53e-9 Gut microbiome composition (summer); CESC cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg01017244 chr2:74357527 NA 0.67 9.66 0.51 4.19e-19 Gestational age at birth (maternal effect); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03311339 chr17:64299562 PRKCA 0.58 6.56 0.37 2.73e-10 Gut microbiome composition (summer); CESC cis rs36051895 0.622 rs10974952 chr9:5079828 A/T cg02405213 chr9:5042618 JAK2 -0.5 -6.01 -0.35 5.99e-9 Pediatric autoimmune diseases; CESC cis rs561341 0.769 rs7217004 chr17:30178092 A/G cg12193833 chr17:30244370 NA 0.62 5.74 0.33 2.58e-8 Hip circumference adjusted for BMI; CESC cis rs6460942 1.000 rs73053527 chr7:12313008 C/A cg06484146 chr7:12443880 VWDE -0.81 -8.78 -0.47 2.13e-16 Coronary artery disease; CESC cis rs12477438 0.748 rs4851185 chr2:99666497 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs916888 0.821 rs415430 chr17:44859144 C/T cg15921436 chr17:44337874 NA -0.71 -8.07 -0.44 2.47e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12135062 0.851 rs2651927 chr1:3101762 A/C cg00254258 chr1:3105189 PRDM16 -0.35 -5.21 -0.3 3.76e-7 Migraine; CESC cis rs9291683 0.679 rs13137795 chr4:10051506 G/A cg00071950 chr4:10020882 SLC2A9 0.81 14.28 0.66 1.04e-34 Bone mineral density; CESC cis rs4629180 0.593 rs6707517 chr2:102089878 C/T cg01388757 chr2:102091195 RFX8 -0.44 -6.74 -0.38 9.61e-11 Chronic rhinosinusitis with nasal polyps; CESC cis rs9527 0.545 rs10883847 chr10:104958284 C/T cg04362960 chr10:104952993 NT5C2 0.44 5.56 0.32 6.74e-8 Arsenic metabolism; CESC cis rs258892 0.895 rs34670 chr5:72162863 T/C cg21869765 chr5:72125136 TNPO1 0.44 5.55 0.32 6.92e-8 Small cell lung carcinoma; CESC cis rs7100689 0.784 rs10736342 chr10:82130005 A/G cg00277334 chr10:82204260 NA -0.59 -7.35 -0.41 2.39e-12 Post bronchodilator FEV1; CESC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg05890377 chr2:74357713 NA 0.68 8.24 0.45 8.21e-15 Gestational age at birth (maternal effect); CESC cis rs7250872 0.647 rs2304613 chr19:1817943 G/C cg10370574 chr19:1840461 REXO1 -0.43 -6.02 -0.35 5.82e-9 Bipolar disorder; CESC cis rs9913156 0.707 rs9902000 chr17:4582426 A/C cg00122941 chr17:4613640 ARRB2 -0.74 -8.99 -0.48 4.81e-17 Lymphocyte counts; CESC cis rs3741151 1.000 rs74346863 chr11:73054772 C/T cg17517138 chr11:73019481 ARHGEF17 1.04 7.13 0.4 9.44e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs5758511 0.680 rs5758686 chr22:42655377 G/T cg00645731 chr22:42541494 CYP2D7P1 0.58 8.74 0.47 2.75e-16 Birth weight; CESC cis rs67311347 1.000 rs11706148 chr3:40407243 A/C cg09455208 chr3:40491958 NA 0.52 8.6 0.47 7.3e-16 Renal cell carcinoma; CESC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg25036284 chr2:26402008 FAM59B -0.47 -5.64 -0.33 4.43e-8 Gut microbiome composition (summer); CESC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg11366901 chr6:160182831 ACAT2 0.81 10.47 0.54 1.08e-21 Age-related macular degeneration (geographic atrophy); CESC cis rs2637266 1.000 rs11001829 chr10:78343387 A/T cg18941641 chr10:78392320 NA 0.41 7.78 0.43 1.65e-13 Pulmonary function; CESC cis rs763121 0.925 rs9611008 chr22:39098787 T/C cg14440974 chr22:39074834 NA -0.36 -5.18 -0.3 4.31e-7 Menopause (age at onset); CESC cis rs910316 1.000 rs10143132 chr14:75525850 G/A cg08847533 chr14:75593920 NEK9 0.99 18.49 0.75 1.4e-49 Height; CESC cis rs56399783 0.614 rs116929101 chr7:2760325 G/A cg19731401 chr7:2775893 GNA12 0.59 5.16 0.3 4.95e-7 Childhood ear infection; CESC cis rs6088580 0.634 rs6059868 chr20:33079460 A/G cg24642439 chr20:33292090 TP53INP2 0.51 6.64 0.38 1.8e-10 Glomerular filtration rate (creatinine); CESC cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1670533 1.000 rs4690213 chr4:1054868 C/T cg27284194 chr4:1044797 NA 0.47 5.99 0.35 6.72e-9 Recombination rate (females); CESC cis rs11229555 0.645 rs36019763 chr11:58232283 G/T cg15696309 chr11:58395628 NA -0.45 -5.22 -0.31 3.63e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs6570726 0.846 rs409553 chr6:145886963 C/T cg23711669 chr6:146136114 FBXO30 0.85 12.88 0.62 8.09e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs5753037 0.630 rs140111 chr22:30131570 A/G cg01021169 chr22:30184971 ASCC2 -0.47 -6.6 -0.38 2.29e-10 Type 1 diabetes; CESC cis rs1256061 0.603 rs1152579 chr14:64695087 A/G cg23250157 chr14:64679961 SYNE2 0.53 7.52 0.42 8.32e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg16425592 chr11:842748 TSPAN4;POLR2L -0.76 -10.21 -0.53 7.68e-21 Mean platelet volume; CESC cis rs6088580 0.634 rs13041646 chr20:33082881 T/A cg24642439 chr20:33292090 TP53INP2 0.51 6.67 0.38 1.46e-10 Glomerular filtration rate (creatinine); CESC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg10691866 chr7:65817282 TPST1 -0.32 -5.38 -0.31 1.61e-7 Aortic root size; CESC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg12311346 chr5:56204834 C5orf35 -0.67 -6.69 -0.38 1.3100000000000001e-10 Type 2 diabetes; CESC cis rs6570726 0.967 rs413880 chr6:145804822 G/A cg23711669 chr6:146136114 FBXO30 0.72 10.46 0.54 1.16e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs10744422 0.858 rs2292136 chr12:123339344 A/G cg25930673 chr12:123319894 HIP1R -0.76 -5.88 -0.34 1.26e-8 Schizophrenia; CESC cis rs12620999 0.774 rs6711726 chr2:238101795 C/T cg23555395 chr2:238036564 NA -0.4 -5.34 -0.31 1.97e-7 Systemic lupus erythematosus; CESC cis rs2637266 0.678 rs864027 chr10:78532061 G/A cg18941641 chr10:78392320 NA 0.39 7.71 0.43 2.5e-13 Pulmonary function; CESC cis rs7605827 0.930 rs1024870 chr2:15625846 T/C cg19274914 chr2:15703543 NA 0.36 6.49 0.37 4.08e-10 Educational attainment (years of education); CESC trans rs9329221 0.510 rs4841282 chr8:9975604 C/A cg06636001 chr8:8085503 FLJ10661 0.51 6.61 0.38 2.12e-10 Neuroticism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01334186 chr1:151372572 PSMB4 0.48 6.31 0.36 1.2e-9 Gut microbiota (bacterial taxa); CESC cis rs728616 0.558 rs2880599 chr10:82164435 A/G cg05935833 chr10:81318306 SFTPA2 -0.46 -5.68 -0.33 3.5e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs1801251 0.778 rs2592116 chr2:233735709 G/A cg08000102 chr2:233561755 GIGYF2 -0.58 -7.82 -0.43 1.22e-13 Coronary artery disease; CESC cis rs7953249 0.807 rs7310409 chr12:121424861 A/G cg02403541 chr12:121454288 C12orf43 -0.48 -6.38 -0.37 7.75e-10 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs2708240 0.599 rs1613285 chr7:147520530 A/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.09 -0.3 6.68e-7 QT interval (drug interaction); CESC cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg00255919 chr5:131827918 IRF1 0.51 8.68 0.47 4.19e-16 Asthma (sex interaction); CESC cis rs2635047 1.000 rs2684841 chr18:44724262 C/T cg19077165 chr18:44547161 KATNAL2 -0.43 -5.97 -0.34 7.4e-9 Educational attainment; CESC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg22143856 chr6:28129313 ZNF389 0.52 6.77 0.38 8.31e-11 Depression; CESC trans rs9329221 0.521 rs17693945 chr8:10106010 C/T cg15556689 chr8:8085844 FLJ10661 -0.53 -6.21 -0.36 2.07e-9 Neuroticism; CESC cis rs9487051 0.735 rs352837 chr6:109521806 C/T cg01475377 chr6:109611718 NA 0.38 5.67 0.33 3.76e-8 Reticulocyte fraction of red cells; CESC cis rs7845219 0.544 rs9643350 chr8:95917276 C/A cg23172400 chr8:95962367 TP53INP1 -0.37 -6.83 -0.39 5.67e-11 Type 2 diabetes; CESC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg23643435 chr2:38893251 GALM -0.65 -8.9 -0.48 8.72e-17 5-HTT brain serotonin transporter levels; CESC cis rs3733585 0.699 rs57574512 chr4:9960182 T/C cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs17253792 0.822 rs10147380 chr14:56054354 T/C cg01858014 chr14:56050164 KTN1 -0.82 -6.45 -0.37 5.37e-10 Putamen volume; CESC cis rs116095464 0.558 rs62344300 chr5:246336 A/G cg20965017 chr5:231967 SDHA -0.47 -5.38 -0.31 1.65e-7 Breast cancer; CESC cis rs6430585 0.528 rs3098102 chr2:136654833 C/T cg07169764 chr2:136633963 MCM6 1.04 15.27 0.68 3.34e-38 Corneal structure; CESC cis rs1707322 0.721 rs11211181 chr1:46236800 C/T cg05343316 chr1:45956843 TESK2 0.48 6.11 0.35 3.51e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg03467027 chr4:99064603 C4orf37 0.45 5.62 0.33 4.95e-8 Colonoscopy-negative controls vs population controls; CESC cis rs5769765 0.817 rs9616212 chr22:50317687 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.63 -6.44 -0.37 5.53e-10 Schizophrenia; CESC cis rs11931598 0.513 rs3857170 chr4:7003366 A/T cg26116260 chr4:7069785 GRPEL1 0.43 6.03 0.35 5.47e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg04944784 chr2:26401820 FAM59B -0.95 -10.38 -0.54 2.13e-21 Gut microbiome composition (summer); CESC cis rs763014 0.931 rs2071980 chr16:626346 A/C cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.25e-7 Height; CESC cis rs10129255 0.500 rs8006888 chr14:107190456 A/C cg07958169 chr14:107095056 NA -0.53 -8.28 -0.45 6.23e-15 Kawasaki disease; CESC cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg03433033 chr1:76189801 ACADM 0.68 8.11 0.45 1.9e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4704187 0.663 rs6889760 chr5:74503704 A/C cg03227963 chr5:74354835 NA 0.28 5.18 0.3 4.33e-7 Response to amphetamines; CESC cis rs9287719 0.967 rs10206225 chr2:10758657 A/G cg02196655 chr2:10830764 NOL10 -0.36 -5.62 -0.33 4.93e-8 Prostate cancer; CESC cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg22875332 chr1:76189707 ACADM -0.62 -6.57 -0.37 2.73e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs6875291 chr5:264192 T/C cg22857025 chr5:266934 NA -1.3 -18.55 -0.75 8.05e-50 Breast cancer; CESC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg16049864 chr8:95962084 TP53INP1 0.62 9.17 0.49 1.37e-17 Type 2 diabetes; CESC cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg05347473 chr6:146136440 FBXO30 0.58 7.57 0.42 6.18e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs9948 0.655 rs62152771 chr2:97447121 C/G cg01990225 chr2:97406019 LMAN2L -0.98 -7.25 -0.41 4.67e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg14983838 chr19:29218262 NA 0.52 5.99 0.35 6.65e-9 Methadone dose in opioid dependence; CESC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs2273669 0.667 rs11153148 chr6:109304084 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.07 -0.35 4.34e-9 Prostate cancer; CESC trans rs2797160 0.904 rs1612274 chr6:126014907 C/A cg05039488 chr6:79577232 IRAK1BP1 0.48 6.31 0.36 1.18e-9 Endometrial cancer; CESC cis rs3845702 0.866 rs818659 chr2:180870893 G/A cg01881094 chr2:180872142 CWC22 0.65 6.71 0.38 1.16e-10 Schizophrenia; CESC cis rs1983891 0.706 rs745548 chr6:41557117 G/T cg20194872 chr6:41519635 FOXP4 -0.45 -6.34 -0.36 9.98e-10 Prostate cancer; CESC cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09645772 chr5:180688272 TRIM52 0.47 6.18 0.35 2.43e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.51 6.37 0.36 8.35e-10 Tonsillectomy; CESC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg03352830 chr11:487213 PTDSS2 0.7 6.74 0.38 1.01e-10 Body mass index; CESC cis rs12900413 0.687 rs6496601 chr15:90317694 C/T cg24249390 chr15:90295951 MESP1 -0.4 -5.63 -0.33 4.62e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs950027 0.620 rs2453533 chr15:45641225 C/A cg21132104 chr15:45694354 SPATA5L1 0.67 8.55 0.46 1.01e-15 Response to fenofibrate (adiponectin levels); CESC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.41 -0.37 6.57e-10 Life satisfaction; CESC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg02569458 chr12:86230093 RASSF9 0.48 7.19 0.4 6.74e-12 Major depressive disorder; CESC cis rs870825 0.616 rs9631782 chr4:185626379 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs7590368 0.706 rs56268818 chr2:10956011 C/T cg15705551 chr2:10952987 PDIA6 0.52 5.12 0.3 5.91e-7 Educational attainment (years of education); CESC cis rs6545977 0.531 rs2539981 chr2:63104904 T/C cg17519650 chr2:63277830 OTX1 0.66 9.29 0.5 5.78e-18 Prostate cancer; CESC trans rs11098499 0.954 rs12502423 chr4:120424172 A/C cg25214090 chr10:38739885 LOC399744 0.7 9.73 0.51 2.51e-19 Corneal astigmatism; CESC cis rs6429082 0.764 rs2481095 chr1:235695756 T/C cg26050004 chr1:235667680 B3GALNT2 -0.57 -6.84 -0.39 5.54e-11 Adiposity; CESC cis rs7208859 0.673 rs11652370 chr17:29097223 G/A cg04154034 chr17:28927549 LRRC37B2 0.55 5.23 0.31 3.39e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9790314 1.000 rs6441373 chr3:161026717 T/G cg03342759 chr3:160939853 NMD3 -0.44 -5.77 -0.33 2.15e-8 Morning vs. evening chronotype; CESC cis rs9457247 0.967 rs2769346 chr6:167370999 A/G cg07741184 chr6:167504864 NA -0.3 -5.28 -0.31 2.64e-7 Crohn's disease; CESC cis rs10129255 0.530 rs11624912 chr14:107129907 A/G cg23076370 chr14:107095027 NA -0.62 -9.35 -0.5 3.79e-18 Kawasaki disease; CESC cis rs17384381 0.861 rs34561661 chr1:85777250 C/T cg16011679 chr1:85725395 C1orf52 0.88 9.06 0.49 3.04e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs10256972 0.869 rs13236369 chr7:1033799 G/T cg07930192 chr7:1003750 NA 0.4 5.4 0.31 1.51e-7 Longevity;Endometriosis; CESC cis rs72781680 0.533 rs56009471 chr2:23890084 A/C cg20701182 chr2:24300061 SF3B14 0.68 6.37 0.36 8.46e-10 Lymphocyte counts; CESC cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg20476274 chr7:133979776 SLC35B4 0.57 7.95 0.44 5.42e-14 Mean platelet volume; CESC cis rs9611565 0.512 rs139571 chr22:42214238 G/A cg06481639 chr22:41940642 POLR3H -0.58 -5.72 -0.33 2.87e-8 Vitiligo; CESC cis rs9908102 0.740 rs7215565 chr17:12900517 G/A cg26162695 chr17:12921313 ELAC2 0.52 5.72 0.33 2.91e-8 Schizophrenia; CESC cis rs4790333 0.715 rs2447110 chr17:2261677 A/G cg02569219 chr17:2266849 SGSM2 0.43 5.92 0.34 9.78e-9 Proinsulin levels; CESC cis rs1355223 0.506 rs1509659 chr11:34865133 A/G cg11058730 chr11:34937778 PDHX;APIP -0.54 -6.72 -0.38 1.12e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6088580 0.634 rs6059890 chr20:33101653 G/C cg06115741 chr20:33292138 TP53INP2 0.44 5.69 0.33 3.38e-8 Glomerular filtration rate (creatinine); CESC cis rs9840812 0.623 rs6794351 chr3:136292279 C/T cg15507776 chr3:136538369 TMEM22 0.43 5.19 0.3 4.27e-7 Fibrinogen levels; CESC cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg24308560 chr3:49941425 MST1R 0.6 8.72 0.47 3.17e-16 Body mass index; CESC cis rs7659604 0.967 rs10008348 chr4:122666987 A/C cg19671926 chr4:122722719 EXOSC9 -0.49 -5.98 -0.35 7.01e-9 Type 2 diabetes; CESC cis rs6499255 0.951 rs60472033 chr16:69677709 A/G cg15192750 chr16:69999425 NA 0.47 5.54 0.32 7.28e-8 IgE levels; CESC cis rs7617773 0.817 rs9847953 chr3:48282695 A/G cg11946769 chr3:48343235 NME6 0.79 10.88 0.56 4.99e-23 Coronary artery disease; CESC cis rs6831352 0.837 rs2924583 chr4:100044640 T/C cg13256891 chr4:100009986 ADH5 0.74 8.21 0.45 9.57e-15 Alcohol dependence; CESC cis rs9649465 1.000 rs7803287 chr7:123354807 T/C cg04330084 chr7:123175371 IQUB -0.39 -5.23 -0.31 3.47e-7 Migraine; CESC trans rs2727020 0.576 rs1917321 chr11:49377760 A/C cg00717180 chr2:96193071 NA -0.44 -6.25 -0.36 1.63e-9 Coronary artery disease; CESC trans rs10463316 0.894 rs13361298 chr5:150765549 T/C cg24389359 chr12:111284228 CCDC63 -0.34 -6.08 -0.35 4.19e-9 Metabolite levels (Pyroglutamine); CESC cis rs10504073 0.584 rs60449482 chr8:49974865 G/A cg00325661 chr8:49890786 NA 0.59 8.9 0.48 9.3e-17 Blood metabolite ratios; CESC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg06634786 chr22:41940651 POLR3H 0.68 7.08 0.4 1.33e-11 Vitiligo; CESC cis rs28830936 0.528 rs11630242 chr15:42124643 T/C cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.38 -5.91 -0.34 1.04e-8 Diastolic blood pressure; CESC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg11764359 chr7:65958608 NA -0.81 -9.98 -0.52 4.19e-20 Aortic root size; CESC cis rs10504229 0.679 rs16921623 chr8:58039473 G/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg20243544 chr17:37824526 PNMT -0.45 -5.39 -0.31 1.59e-7 Glomerular filtration rate (creatinine); CESC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg02569458 chr12:86230093 RASSF9 0.48 7.58 0.42 5.99e-13 Major depressive disorder; CESC cis rs116095464 0.558 rs10058428 chr5:235608 A/G cg10591111 chr5:226296 SDHA -0.51 -6.29 -0.36 1.32e-9 Breast cancer; CESC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg22535103 chr8:58192502 C8orf71 -0.95 -10.54 -0.54 6.39e-22 Developmental language disorder (linguistic errors); CESC cis rs561341 1.000 rs535151 chr17:30317405 C/T cg23018236 chr17:30244563 NA -0.45 -5.55 -0.32 6.83e-8 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02284982 chr2:128145269 NA 0.57 6.91 0.39 3.63e-11 Gut microbiome composition (summer); CESC cis rs34375054 0.738 rs3751181 chr12:125626535 A/G cg25124228 chr12:125621409 AACS -0.61 -8.29 -0.45 5.58e-15 Post bronchodilator FEV1/FVC ratio; CESC cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg02487422 chr3:49467188 NICN1 0.5 6.35 0.36 9.14e-10 Parkinson's disease; CESC cis rs10242455 0.702 rs1045012 chr7:98984354 G/C cg25640893 chr7:99214727 ZNF498 1.04 6.35 0.36 9.57e-10 Blood metabolite levels; CESC cis rs7772486 0.686 rs9497396 chr6:146014963 C/A cg23711669 chr6:146136114 FBXO30 -0.88 -12.63 -0.61 6.23e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs2576037 0.796 rs2576034 chr18:44588548 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.45 5.75 0.33 2.48e-8 Personality dimensions; CESC cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg12292205 chr6:26970375 C6orf41 -0.53 -5.76 -0.33 2.33e-8 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.34 0.5 3.98e-18 Menopause (age at onset); CESC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg18402987 chr7:1209562 NA 0.76 7.58 0.42 5.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6831352 0.918 rs17218141 chr4:100055908 T/C cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21564803 chr22:43485544 TTLL1 -0.44 -6.46 -0.37 4.94e-10 Gambling; CESC cis rs9303401 0.704 rs740605 chr17:56604811 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.53 6.92 0.39 3.33e-11 Cognitive test performance; CESC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg11494091 chr17:61959527 GH2 -0.72 -12.61 -0.61 7.13e-29 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25215298 chr1:860022 SAMD11 0.63 7.84 0.43 1.13e-13 Gut microbiome composition (summer); CESC cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg03060546 chr3:49711283 APEH 0.44 5.44 0.32 1.18e-7 Parkinson's disease; CESC cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg03060546 chr3:49711283 APEH 0.51 6.16 0.35 2.66e-9 Parkinson's disease; CESC cis rs6835098 0.961 rs28709762 chr4:174099149 T/C cg08422745 chr4:174089978 GALNT7 -0.72 -9.42 -0.5 2.37e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC trans rs629535 0.814 rs55873935 chr8:70081646 G/A cg21567404 chr3:27674614 NA -0.88 -10.3 -0.53 3.7e-21 Dupuytren's disease; CESC cis rs9811920 0.965 rs9849632 chr3:99867211 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.45 7.37 0.41 2.19e-12 Axial length; CESC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg22823121 chr1:150693482 HORMAD1 -0.41 -6.39 -0.37 7.49e-10 Tonsillectomy; CESC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg00684032 chr4:1343700 KIAA1530 0.42 6.02 0.35 5.68e-9 Obesity-related traits; CESC cis rs7592578 0.639 rs61709084 chr2:191287685 A/C cg10560079 chr2:191398806 TMEM194B -0.6 -5.99 -0.35 6.83e-9 Diastolic blood pressure; CESC cis rs11642862 0.792 rs75586365 chr16:30996363 C/T cg02466173 chr16:30829666 NA -0.57 -5.21 -0.3 3.81e-7 Tonsillectomy; CESC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg03351412 chr1:154909251 PMVK 0.68 9.09 0.49 2.32e-17 Prostate cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00031476 chr2:28114244 BRE;RBKS;LOC100302650 0.39 6.05 0.35 4.83e-9 Gambling; CESC cis rs4727027 0.933 rs12704063 chr7:148827909 T/C cg23583168 chr7:148888333 NA -0.79 -12.21 -0.6 1.63e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9303280 0.901 rs2313430 chr17:37929816 T/C cg19468946 chr17:37922297 IKZF3 0.37 5.1 0.3 6.46e-7 Self-reported allergy; CESC cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.58 8.89 0.48 9.9e-17 Breast cancer; CESC cis rs10751667 1.000 rs7395632 chr11:958789 C/T cg20946044 chr11:1010712 AP2A2 0.4 5.42 0.32 1.34e-7 Alzheimer's disease (late onset); CESC cis rs9815354 0.812 rs4264702 chr3:41952539 T/A cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.9e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6580649 0.769 rs60629297 chr12:48438290 T/A cg05342945 chr12:48394962 COL2A1 0.5 5.67 0.33 3.69e-8 Lung cancer; CESC cis rs2228479 0.702 rs11649501 chr16:89850957 A/T cg19635926 chr16:89946313 TCF25 0.67 5.08 0.3 7.08e-7 Skin colour saturation; CESC cis rs4803468 0.967 rs4803462 chr19:41908936 T/A cg14132834 chr19:41945861 ATP5SL -0.65 -8.1 -0.45 2.05e-14 Height; CESC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.58 5.69 0.33 3.43e-8 Cerebrospinal P-tau181p levels; CESC cis rs2070997 0.667 rs13295907 chr9:133718242 G/T cg11464064 chr9:133710261 ABL1 0.66 7.38 0.41 1.99e-12 Response to amphetamines; CESC cis rs7727544 0.660 rs2631361 chr5:131707380 C/A cg07395648 chr5:131743802 NA 0.39 5.14 0.3 5.25e-7 Blood metabolite levels; CESC cis rs7107174 0.792 rs12291726 chr11:78088210 A/G cg02023728 chr11:77925099 USP35 0.46 6.08 0.35 4.14e-9 Testicular germ cell tumor; CESC cis rs10752881 0.875 rs10752894 chr1:183050610 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 13.7 0.64 1.21e-32 Colorectal cancer; CESC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26894841 chr16:90016551 DEF8 0.33 6.0 0.35 6.52e-9 Electrocardiographic conduction measures; CESC cis rs17376456 0.877 rs10059230 chr5:93450347 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.44 0.32 1.23e-7 Diabetic retinopathy; CESC cis rs6121246 0.529 rs6060145 chr20:30178631 T/C cg13852791 chr20:30311386 BCL2L1 0.61 5.83 0.34 1.62e-8 Mean corpuscular hemoglobin; CESC cis rs4148883 0.504 rs28720150 chr4:100132790 T/G cg13256891 chr4:100009986 ADH5 -0.5 -6.6 -0.38 2.2e-10 Alcohol dependence; CESC cis rs13082711 0.911 rs2172298 chr3:27425611 T/C cg02860705 chr3:27208620 NA 0.52 6.57 0.37 2.64e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs11155671 0.530 rs7756850 chr6:150212596 G/C cg09699651 chr6:150184138 LRP11 0.54 7.4 0.41 1.79e-12 Testicular germ cell tumor; CESC cis rs941408 1.000 rs2260416 chr19:2796355 G/A cg00079169 chr19:2811669 THOP1 0.45 6.44 0.37 5.69e-10 Total cholesterol levels; CESC trans rs7246657 0.943 rs2891699 chr19:37920237 A/G cg24637308 chr11:6592297 DNHD1 0.54 6.34 0.36 1.01e-9 Coronary artery calcification; CESC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg11629889 chr17:40839022 CNTNAP1 0.54 8.62 0.47 6.23e-16 Colorectal or endometrial cancer; CESC trans rs7668874 0.779 rs7697741 chr4:116805075 A/G cg05356848 chr7:140098092 SLC37A3 0.64 6.34 0.36 1e-9 Response to platinum-based chemotherapy (carboplatin); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13917004 chr19:42462874 RABAC1 -0.52 -6.6 -0.38 2.19e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9309473 1.000 rs11689392 chr2:73622026 T/C cg20560298 chr2:73613845 ALMS1 -0.47 -6.34 -0.36 9.83e-10 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04422277 chr15:30918065 ARHGAP11B -0.58 -6.84 -0.39 5.38e-11 Gut microbiome composition (summer); CESC cis rs1451375 0.617 rs1376524 chr7:50563582 G/A cg14593290 chr7:50529359 DDC -0.5 -6.26 -0.36 1.59e-9 Malaria; CESC cis rs950776 0.616 rs56276142 chr15:78889795 T/C cg24631222 chr15:78858424 CHRNA5 -0.43 -5.43 -0.32 1.25e-7 Sudden cardiac arrest; CESC cis rs7851660 0.805 rs10759981 chr9:100635780 A/G cg13688889 chr9:100608707 NA -0.62 -8.62 -0.47 6.13e-16 Strep throat; CESC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg22143856 chr6:28129313 ZNF389 0.53 6.86 0.39 4.9e-11 Depression; CESC cis rs2066819 1.000 rs78149779 chr12:56694817 A/G cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs12477438 0.520 rs2632277 chr2:99778985 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.95 0.7 1.29e-40 Chronic sinus infection; CESC cis rs4319547 0.626 rs10744210 chr12:122931793 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -5.77 -0.33 2.19e-8 Body mass index; CESC cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg02221750 chr19:17393354 ANKLE1 -0.51 -6.24 -0.36 1.71e-9 Systemic lupus erythematosus; CESC cis rs116095464 0.558 rs28635197 chr5:279071 T/C cg22857025 chr5:266934 NA -1.29 -18.38 -0.75 3.21e-49 Breast cancer; CESC cis rs67311347 1.000 rs2305522 chr3:40429358 A/G cg24209194 chr3:40518798 ZNF619 0.47 6.07 0.35 4.32e-9 Renal cell carcinoma; CESC cis rs116095464 0.558 rs7356696 chr5:284251 A/G cg20965017 chr5:231967 SDHA -0.46 -5.2 -0.3 4.02e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14714711 chr20:13619694 TASP1 0.6 6.23 0.36 1.82e-9 Gut microbiome composition (summer); CESC cis rs1832871 0.711 rs6906854 chr6:158695000 C/T cg07165851 chr6:158734300 TULP4 0.57 5.97 0.34 7.78e-9 Height; CESC cis rs6032067 0.777 rs56063128 chr20:43783210 G/A cg10761708 chr20:43804764 PI3 0.54 6.43 0.37 5.89e-10 Blood protein levels; CESC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg11987759 chr7:65425863 GUSB 0.46 6.14 0.35 2.94e-9 Aortic root size; CESC cis rs7107174 1.000 rs2450122 chr11:77930345 T/C cg02023728 chr11:77925099 USP35 0.46 5.86 0.34 1.35e-8 Testicular germ cell tumor; CESC cis rs2859741 0.528 rs2359647 chr1:37483054 A/T cg09363841 chr1:37513479 NA -0.5 -7.19 -0.4 6.5e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs9309473 0.607 rs6546824 chr2:73587331 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.2 -0.36 2.14e-9 Metabolite levels; CESC cis rs12142240 0.698 rs7525309 chr1:46809025 G/T cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC trans rs208520 0.954 rs72884027 chr6:66995044 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.14 0.49 1.65e-17 Exhaled nitric oxide output; CESC cis rs4455778 0.565 rs7809432 chr7:49014472 C/T cg26309511 chr7:48887640 NA -0.35 -5.1 -0.3 6.4e-7 Lung cancer in never smokers; CESC cis rs9527 0.590 rs10883830 chr10:104851285 G/A cg04362960 chr10:104952993 NT5C2 0.44 5.6 0.33 5.49e-8 Arsenic metabolism; CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg18402987 chr7:1209562 NA 0.4 5.16 0.3 4.94e-7 Longevity;Endometriosis; CESC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.26 0.36 1.52e-9 Bipolar disorder; CESC cis rs11764590 0.694 rs10235664 chr7:2086814 T/C cg21782813 chr7:2030301 MAD1L1 -0.4 -5.35 -0.31 1.91e-7 Neuroticism; CESC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg05368731 chr17:41323189 NBR1 0.58 8.27 0.45 6.71e-15 Menopause (age at onset); CESC cis rs7727544 0.735 rs272875 chr5:131674888 T/C cg07395648 chr5:131743802 NA -0.47 -6.3 -0.36 1.25e-9 Blood metabolite levels; CESC cis rs2228479 0.867 rs11645970 chr16:89958118 G/A cg06558623 chr16:89946397 TCF25 1.08 9.18 0.49 1.3e-17 Skin colour saturation; CESC cis rs8028182 0.636 rs28783769 chr15:75849009 C/A cg20655648 chr15:75932815 IMP3 0.49 5.95 0.34 8.55e-9 Sudden cardiac arrest; CESC cis rs826838 0.967 rs1719858 chr12:39124505 C/T cg26384229 chr12:38710491 ALG10B -0.67 -11.02 -0.56 1.72e-23 Heart rate; CESC trans rs61931739 0.500 rs7309931 chr12:34483471 A/C cg26384229 chr12:38710491 ALG10B 0.55 7.58 0.42 5.66e-13 Morning vs. evening chronotype; CESC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.52 -0.32 7.98e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs12579753 0.719 rs4384447 chr12:82268069 G/C cg23701643 chr12:82153290 PPFIA2 -0.36 -5.27 -0.31 2.81e-7 Resting heart rate; CESC cis rs7772486 0.686 rs702305 chr6:145973840 A/G cg23711669 chr6:146136114 FBXO30 -0.91 -13.72 -0.64 9.83e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs9911578 0.967 rs6503883 chr17:56917543 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 3.04e-7 Intelligence (multi-trait analysis); CESC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg18252515 chr7:66147081 NA -0.43 -5.62 -0.33 4.9e-8 Aortic root size; CESC cis rs9916302 0.904 rs35285898 chr17:37555872 A/C cg07936489 chr17:37558343 FBXL20 0.8 11.5 0.58 4.2e-25 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16001793 chr1:161369711 NA 0.57 6.5 0.37 3.94e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04334422 chr4:8398880 ACOX3 0.47 6.11 0.35 3.45e-9 Fibrinogen levels; CESC cis rs2204008 0.744 rs67889662 chr12:38327042 T/A cg13010199 chr12:38710504 ALG10B 0.53 6.54 0.37 3.12e-10 Bladder cancer; CESC cis rs9300255 0.508 rs1716176 chr12:123655467 T/G cg05973401 chr12:123451056 ABCB9 0.54 6.04 0.35 5.31e-9 Neutrophil percentage of white cells; CESC cis rs501120 0.810 rs684196 chr10:44745950 A/T cg09554077 chr10:44749378 NA 0.5 6.64 0.38 1.74e-10 Coronary artery disease;Coronary heart disease; CESC cis rs644799 1.000 rs627568 chr11:95569253 A/C cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.53 0.37 3.43e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7927592 0.673 rs498782 chr11:68275851 A/G cg20283391 chr11:68216788 NA -0.45 -5.64 -0.33 4.39e-8 Total body bone mineral density; CESC cis rs2288073 0.619 rs6713263 chr2:24375463 A/G cg06627628 chr2:24431161 ITSN2 -0.5 -6.54 -0.37 3.24e-10 Venous thromboembolism (SNP x SNP interaction); CESC cis rs9443189 1.000 rs3822957 chr6:76607280 A/G cg01950844 chr6:76311363 SENP6 -0.61 -6.31 -0.36 1.18e-9 Prostate cancer; CESC cis rs2243480 1.000 rs4149468 chr7:65825690 T/C cg18252515 chr7:66147081 NA -1.39 -14.0 -0.65 1.04e-33 Diabetic kidney disease; CESC cis rs3087591 1.000 rs6505235 chr17:29688603 C/A cg24425628 chr17:29625626 OMG;NF1 -0.48 -5.99 -0.35 6.66e-9 Hip circumference; CESC cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg13628971 chr7:2884303 GNA12 0.43 5.76 0.33 2.35e-8 Height; CESC cis rs7385804 0.633 rs221795 chr7:100283261 C/T cg20848291 chr7:100343083 ZAN 0.56 7.72 0.43 2.32e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg18512352 chr11:47633146 NA -0.51 -7.24 -0.41 4.87e-12 Subjective well-being; CESC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg06873352 chr17:61820015 STRADA 0.72 12.6 0.61 7.87e-29 Prudent dietary pattern; CESC cis rs9611519 0.894 rs9611488 chr22:41462592 G/T cg03806693 chr22:41940476 POLR3H -0.57 -5.94 -0.34 8.9e-9 Neuroticism; CESC cis rs4699052 0.662 rs1400363 chr4:104250722 A/C cg16532752 chr4:104119610 CENPE -0.44 -6.49 -0.37 4.12e-10 Testicular germ cell tumor; CESC cis rs7520050 0.966 rs809775 chr1:46538040 A/T cg03146154 chr1:46216737 IPP -0.44 -5.73 -0.33 2.78e-8 Red blood cell count;Reticulocyte count; CESC cis rs6748734 1.000 rs7604393 chr2:241825034 T/G cg04034577 chr2:241836375 C2orf54 -0.48 -8.06 -0.44 2.66e-14 Urinary metabolites; CESC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg24399712 chr22:39784796 NA -0.83 -10.33 -0.54 2.97e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs6570726 0.764 rs9403731 chr6:145907937 G/A cg23711669 chr6:146136114 FBXO30 0.9 13.39 0.64 1.41e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs3733585 0.699 rs10017674 chr4:9967053 T/C cg00071950 chr4:10020882 SLC2A9 -0.7 -11.44 -0.58 6.69e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6912958 0.781 rs9444522 chr6:88309705 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.69 -0.38 1.35e-10 Monocyte percentage of white cells; CESC cis rs2735413 0.632 rs4436790 chr16:78097252 G/A cg04733911 chr16:78082701 NA 0.47 7.32 0.41 3.04e-12 Systolic blood pressure (alcohol consumption interaction); CESC cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs2070488 0.965 rs6805386 chr3:38557921 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.91 -16.76 -0.72 1.69e-43 Electrocardiographic conduction measures; CESC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg00129232 chr17:37814104 STARD3 0.57 7.44 0.42 1.38e-12 Glomerular filtration rate (creatinine); CESC cis rs10242455 0.702 rs74552228 chr7:98977046 C/T cg25640893 chr7:99214727 ZNF498 0.94 5.73 0.33 2.71e-8 Blood metabolite levels; CESC cis rs3806843 0.808 rs6893708 chr5:140125922 T/C cg26395211 chr5:140044315 WDR55 0.39 5.13 0.3 5.55e-7 Depressive symptoms (multi-trait analysis); CESC cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9611565 0.649 rs202645 chr22:41798520 A/G cg06481639 chr22:41940642 POLR3H 0.64 6.58 0.37 2.51e-10 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01382281 chr19:56104340 FIZ1 0.46 6.05 0.35 4.99e-9 Fibrinogen levels; CESC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg05872129 chr22:39784769 NA -0.75 -9.12 -0.49 2e-17 Intelligence (multi-trait analysis); CESC trans rs877282 0.583 rs10904566 chr10:821662 C/G cg22713356 chr15:30763199 NA 1.07 9.68 0.51 3.6e-19 Uric acid levels; CESC cis rs2014572 0.967 rs8100154 chr19:57765432 A/G cg12963866 chr19:57752005 ZNF805 -0.48 -6.47 -0.37 4.61e-10 Hyperactive-impulsive symptoms; CESC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg16425592 chr11:842748 TSPAN4;POLR2L -0.75 -9.89 -0.52 7.59e-20 Mean platelet volume; CESC cis rs11676348 0.755 rs1008562 chr2:219026972 G/C cg00012203 chr2:219082015 ARPC2 0.59 7.61 0.42 4.8e-13 Ulcerative colitis; CESC cis rs1609391 0.567 rs835633 chr3:136676496 T/C cg03617693 chr3:136751559 NA 0.37 5.29 0.31 2.62e-7 Neuroticism; CESC cis rs9796 0.621 rs12324159 chr15:41462468 G/A cg18705301 chr15:41695430 NDUFAF1 -0.5 -7.42 -0.41 1.62e-12 Menopause (age at onset); CESC cis rs6032067 0.852 rs17333103 chr20:43803613 C/T cg10761708 chr20:43804764 PI3 0.55 6.55 0.37 2.91e-10 Blood protein levels; CESC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg23048001 chr7:2026167 MAD1L1 0.45 5.74 0.33 2.61e-8 Bipolar disorder and schizophrenia; CESC cis rs2120019 1.000 rs2415255 chr15:75332412 A/G cg17294928 chr15:75287854 SCAMP5 -0.73 -8.22 -0.45 8.88e-15 Blood trace element (Zn levels); CESC trans rs55704346 0.566 rs908056 chr4:25394531 G/A cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs6754311 0.509 rs3820794 chr2:136505546 C/T cg15123519 chr2:136567270 LCT 0.29 5.09 0.3 6.68e-7 Mosquito bite size; CESC cis rs7927771 0.524 rs1563820 chr11:47833398 A/T cg18512352 chr11:47633146 NA -0.36 -5.55 -0.32 6.84e-8 Subjective well-being; CESC cis rs116095464 0.558 rs7730700 chr5:264713 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.49 0.32 9.44e-8 Breast cancer; CESC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg25204440 chr1:209979598 IRF6 0.63 7.82 0.43 1.22e-13 Cleft lip with or without cleft palate; CESC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg08736216 chr1:53307985 ZYG11A 0.32 5.61 0.33 4.96e-8 Monocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01655781 chr12:102513797 NUP37;C12orf48 -0.48 -6.28 -0.36 1.35e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8072100 0.713 rs8075058 chr17:45482857 A/G cg08085267 chr17:45401833 C17orf57 -0.52 -6.64 -0.38 1.81e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9486719 1.000 rs2092096 chr6:96870919 A/G cg18709589 chr6:96969512 KIAA0776 0.56 6.1 0.35 3.8e-9 Migraine;Coronary artery disease; CESC cis rs7223966 1.000 rs9899788 chr17:61756384 G/A cg11494091 chr17:61959527 GH2 0.38 5.35 0.31 1.93e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg17971929 chr21:40555470 PSMG1 -0.87 -12.83 -0.62 1.2e-29 Cognitive function; CESC cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg26597838 chr10:835615 NA 0.7 6.53 0.37 3.31e-10 Eosinophil percentage of granulocytes; CESC cis rs9487051 0.676 rs6910119 chr6:109599263 A/G cg12927641 chr6:109611667 NA -0.36 -5.43 -0.32 1.28e-7 Reticulocyte fraction of red cells; CESC cis rs854765 0.547 rs7223696 chr17:17915791 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.53 7.66 0.43 3.59e-13 Total body bone mineral density; CESC cis rs854765 0.583 rs62064158 chr17:17826935 T/C cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.93e-9 Total body bone mineral density; CESC cis rs10465746 0.657 rs67045520 chr1:84414998 G/T cg10977910 chr1:84465055 TTLL7 0.49 6.45 0.37 5.15e-10 Obesity-related traits; CESC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg22143856 chr6:28129313 ZNF389 0.51 6.55 0.37 3e-10 Depression; CESC cis rs4843747 0.671 rs4075998 chr16:88106776 G/A cg17633681 chr16:88106987 BANP 0.76 10.51 0.54 8.01e-22 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07638871 chr5:56247860 MIER3 -0.51 -6.48 -0.37 4.39e-10 Gut microbiota (bacterial taxa); CESC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg23161317 chr6:28129485 ZNF389 0.4 5.69 0.33 3.29e-8 Cardiac Troponin-T levels; CESC cis rs2404602 0.692 rs7174673 chr15:77071998 T/C cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg24549020 chr5:56110836 MAP3K1 0.59 6.95 0.39 2.75e-11 Initial pursuit acceleration; CESC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg01341218 chr17:43662625 NA -0.85 -10.53 -0.54 6.95e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg23640300 chr22:24059086 LOC91316 -0.45 -6.46 -0.37 4.93e-10 Breast cancer; CESC cis rs3916 0.955 rs35525135 chr12:121140064 T/C cg21892295 chr12:121157589 UNC119B -0.35 -5.12 -0.3 5.93e-7 Urinary metabolites (H-NMR features); CESC cis rs3020736 0.500 rs7292241 chr22:42492063 G/A cg12850546 chr22:42539477 CYP2D7P1 0.45 5.3 0.31 2.4e-7 Autism spectrum disorder or schizophrenia; CESC cis rs8014204 0.748 rs12889277 chr14:75229376 A/T cg08847533 chr14:75593920 NEK9 0.46 5.85 0.34 1.45e-8 Caffeine consumption; CESC cis rs7824557 0.606 rs1435277 chr8:11196970 C/T cg21775007 chr8:11205619 TDH 0.53 7.78 0.43 1.59e-13 Retinal vascular caliber; CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg16145915 chr7:1198662 ZFAND2A -0.58 -9.25 -0.49 7.81e-18 Longevity;Endometriosis; CESC cis rs2250402 0.510 rs7535 chr15:40328575 G/C cg01081584 chr15:40268610 EIF2AK4 -0.56 -5.26 -0.31 3.01e-7 Corneal curvature; CESC trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg15704280 chr7:45808275 SEPT13 -0.58 -6.87 -0.39 4.44e-11 HDL cholesterol; CESC cis rs11190604 1.000 rs2489045 chr10:102344754 C/T cg07080220 chr10:102295463 HIF1AN 0.65 5.97 0.34 7.75e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs6582630 0.555 rs11503799 chr12:38294578 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.63 -0.33 4.55e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg26314531 chr2:26401878 FAM59B -0.62 -6.91 -0.39 3.56e-11 Gut microbiome composition (summer); CESC cis rs4481887 0.636 rs4397683 chr1:248411089 C/T cg00666640 chr1:248458726 OR2T12 0.34 5.43 0.32 1.26e-7 Common traits (Other); CESC cis rs826838 0.967 rs7299170 chr12:38789536 G/A cg26384229 chr12:38710491 ALG10B 0.83 14.61 0.67 7.23e-36 Heart rate; CESC cis rs7945705 0.967 rs10769970 chr11:8917937 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.51 8.16 0.45 1.39e-14 Hemoglobin concentration; CESC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.15 -0.35 2.85e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs751728 0.687 rs4711355 chr6:33759906 G/T cg25922239 chr6:33757077 LEMD2 0.44 6.16 0.35 2.7e-9 Crohn's disease; CESC cis rs79839061 0.667 rs73207777 chr4:836046 A/G cg07828340 chr4:882639 GAK 0.81 5.74 0.33 2.62e-8 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08172461 chr2:200820611 C2orf60;C2orf47 0.57 6.52 0.37 3.47e-10 Gut microbiome composition (summer); CESC cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg04455712 chr21:45112962 RRP1B 0.49 7.91 0.44 7.1e-14 Mean corpuscular volume; CESC cis rs12579753 0.719 rs12369450 chr12:82266940 A/G cg23701643 chr12:82153290 PPFIA2 -0.35 -5.19 -0.3 4.11e-7 Resting heart rate; CESC cis rs854765 0.583 rs67253360 chr17:17828973 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.28 0.41 3.9e-12 Total body bone mineral density; CESC cis rs8067545 0.611 rs12938355 chr17:20195217 A/G cg13482628 chr17:19912719 NA -0.42 -5.61 -0.33 5.2e-8 Schizophrenia; CESC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs2204008 0.623 rs1663281 chr12:38120936 A/G cg26384229 chr12:38710491 ALG10B -0.43 -5.92 -0.34 9.92e-9 Bladder cancer; CESC cis rs3892630 0.824 rs12976069 chr19:33280084 G/A cg13157960 chr19:33183277 NUDT19 0.55 5.29 0.31 2.55e-7 Red blood cell traits; CESC cis rs4908760 0.965 rs10864354 chr1:8549741 C/T cg00120948 chr1:8484417 RERE -0.33 -5.15 -0.3 5.07e-7 Vitiligo; CESC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg06873352 chr17:61820015 STRADA 0.72 12.61 0.61 7.18e-29 Prudent dietary pattern; CESC cis rs4595586 0.545 rs2197941 chr12:39402223 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg20476274 chr7:133979776 SLC35B4 0.63 9.19 0.49 1.17e-17 Mean platelet volume; CESC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.98 15.28 0.68 3.16e-38 Platelet count; CESC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.33 -0.31 2.07e-7 Lung cancer; CESC cis rs2594989 0.708 rs2594997 chr3:11365739 A/T cg00170343 chr3:11313890 ATG7 0.56 5.04 0.3 8.52e-7 Circulating chemerin levels; CESC cis rs4076764 0.958 rs10917748 chr1:163400377 T/C cg24596788 chr1:163392923 NA -0.5 -7.17 -0.4 7.57e-12 Motion sickness; CESC cis rs9908102 0.740 rs4792308 chr17:12899726 A/G cg26162695 chr17:12921313 ELAC2 0.52 5.65 0.33 4.11e-8 Schizophrenia; CESC cis rs7107174 1.000 rs2511190 chr11:77988310 T/C cg02023728 chr11:77925099 USP35 0.47 6.49 0.37 4.19e-10 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00300090 chr3:4345167 SETMAR 0.57 6.46 0.37 4.86e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00045303 chr21:37432620 SETD4 0.6 6.35 0.36 9.44e-10 Gut microbiome composition (summer); CESC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Parkinson's disease; CESC cis rs7208859 0.623 rs11657777 chr17:29091785 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10845606 1.000 rs10845607 chr12:12835228 C/T cg09462578 chr12:12878428 APOLD1 -0.66 -7.21 -0.41 5.73e-12 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26634121 chr16:88897219 GALNS -0.63 -7.14 -0.4 9.21e-12 Gut microbiome composition (summer); CESC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg14393609 chr7:65229607 NA -0.45 -6.13 -0.35 3.17e-9 Aortic root size; CESC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg17143192 chr8:8559678 CLDN23 0.74 8.11 0.45 1.85e-14 Obesity-related traits; CESC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg24250549 chr1:154909240 PMVK 0.54 7.21 0.41 5.82e-12 Prostate cancer; CESC trans rs7618501 0.633 rs11130228 chr3:50003246 C/T cg21659725 chr3:3221576 CRBN 0.49 6.79 0.38 7.26e-11 Intelligence (multi-trait analysis); CESC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg08027265 chr7:2291960 NA -0.4 -6.14 -0.35 3.02e-9 Bipolar disorder and schizophrenia; CESC cis rs9649465 1.000 rs627689 chr7:123400543 C/T cg04330084 chr7:123175371 IQUB -0.38 -5.04 -0.3 8.78e-7 Migraine; CESC cis rs10751667 0.666 rs10794347 chr11:939863 G/A cg01483505 chr11:975446 AP2A2 0.38 5.18 0.3 4.33e-7 Alzheimer's disease (late onset); CESC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.88 13.25 0.63 4.33e-31 Prudent dietary pattern; CESC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg18761221 chr20:60518478 NA -0.54 -7.45 -0.42 1.35e-12 Obesity-related traits; CESC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3806843 1.000 rs10038174 chr5:140210616 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.25 -0.31 3.08e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7727544 0.735 rs272860 chr5:131684175 C/G cg24060327 chr5:131705240 SLC22A5 -0.65 -8.62 -0.47 6.22e-16 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13704678 chr3:10362667 SEC13 0.6 6.86 0.39 4.74e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg03467027 chr4:99064603 C4orf37 0.45 5.72 0.33 2.89e-8 Colonoscopy-negative controls vs population controls; CESC cis rs96067 0.772 rs1033891 chr1:36608402 A/G cg24686825 chr1:36642396 MAP7D1 -0.45 -5.15 -0.3 5e-7 Corneal structure; CESC cis rs1559088 0.948 rs7257858 chr19:33591231 T/C cg17764715 chr19:33622953 WDR88 0.49 6.32 0.36 1.11e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg16325326 chr1:53192061 ZYG11B 0.53 7.56 0.42 6.47e-13 Monocyte count; CESC cis rs7927592 0.731 rs2156463 chr11:68386311 T/C cg16797656 chr11:68205561 LRP5 0.48 7.16 0.4 8.17e-12 Total body bone mineral density; CESC cis rs611744 0.647 rs615233 chr8:109254262 C/T cg21045802 chr8:109455806 TTC35 0.49 6.06 0.35 4.71e-9 Dupuytren's disease; CESC cis rs11645898 0.872 rs34832584 chr16:72162966 G/T cg14768367 chr16:72042858 DHODH -0.76 -6.45 -0.37 5.39e-10 Blood protein levels; CESC cis rs116095464 0.542 rs28650039 chr5:273954 C/A cg10591111 chr5:226296 SDHA -0.52 -6.2 -0.36 2.12e-9 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05949034 chr4:83295361 HNRNPD 0.58 6.41 0.37 6.51e-10 Gut microbiome composition (summer); CESC cis rs6484504 0.576 rs208090 chr11:31190992 T/C cg14844989 chr11:31128820 NA -0.42 -6.01 -0.35 6.07e-9 Red blood cell count; CESC cis rs1707322 0.721 rs10890336 chr1:46111056 C/T cg05343316 chr1:45956843 TESK2 0.5 6.05 0.35 4.9e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.76e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg20151795 chr6:28129481 ZNF389 0.41 5.3 0.31 2.46e-7 Parkinson's disease; CESC cis rs2228479 0.850 rs11644526 chr16:89898660 C/T cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg27266027 chr21:40555129 PSMG1 0.44 5.2 0.3 4.05e-7 Cognitive function; CESC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg21548813 chr6:291882 DUSP22 -0.75 -10.35 -0.54 2.55e-21 Menopause (age at onset); CESC cis rs2050392 0.517 rs619864 chr10:30750950 A/G cg25182066 chr10:30743637 MAP3K8 0.51 7.41 0.41 1.72e-12 Inflammatory bowel disease; CESC cis rs13242816 1.000 rs987791 chr7:116134701 A/G cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC cis rs9309473 0.607 rs1522927 chr2:73556155 T/G cg20560298 chr2:73613845 ALMS1 -0.48 -6.47 -0.37 4.65e-10 Metabolite levels; CESC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg03605463 chr16:89740564 NA 0.65 7.77 0.43 1.77e-13 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19602773 chr3:52007747 ABHD14B;ABHD14A 0.55 6.18 0.35 2.42e-9 Gut microbiome composition (summer); CESC cis rs6963495 0.745 rs73192153 chr7:105212418 A/T cg13798780 chr7:105162888 PUS7 0.77 7.56 0.42 6.63e-13 Bipolar disorder (body mass index interaction); CESC cis rs4319547 0.656 rs3817011 chr12:122819566 C/T cg05707623 chr12:122985044 ZCCHC8 -0.5 -5.93 -0.34 9.57e-9 Body mass index; CESC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg27170947 chr2:26402098 FAM59B -0.82 -9.38 -0.5 3.02e-18 Gut microbiome composition (summer); CESC cis rs7909791 0.632 rs11191853 chr10:105657363 C/G cg24587175 chr10:105670608 OBFC1 0.43 5.6 0.33 5.36e-8 White matter hyperintensity burden; CESC cis rs735396 0.770 rs1169301 chr12:121431300 C/T cg02403541 chr12:121454288 C12orf43 0.72 9.79 0.52 1.56e-19 N-glycan levels; CESC cis rs834811 0.829 rs10252049 chr7:135903178 G/A cg01726295 chr7:135938950 NA -0.38 -6.37 -0.36 8.4e-10 Post-traumatic stress disorder; CESC cis rs9303401 0.614 rs3887355 chr17:56538639 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.3 0.6 8.24e-28 Cognitive test performance; CESC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.52 -0.37 3.49e-10 Bipolar disorder; CESC cis rs1153858 1.000 rs10444821 chr15:45647236 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.45e-9 Homoarginine levels; CESC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs796364 0.806 rs10931889 chr2:201101900 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.77 -6.46 -0.37 5.11e-10 Schizophrenia; CESC cis rs3015497 0.527 rs3015473 chr14:51154010 A/G cg26011998 chr14:51135199 SAV1 -0.56 -6.25 -0.36 1.66e-9 Mean platelet volume; CESC cis rs4604732 0.631 rs10925043 chr1:247627001 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4065321 0.522 rs11078930 chr17:38141955 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.61 8.98 0.48 5.1e-17 White blood cell count (basophil);White blood cell count; CESC cis rs8114671 0.836 rs1885114 chr20:33577361 A/G cg06115741 chr20:33292138 TP53INP2 -0.42 -5.04 -0.3 8.75e-7 Height; CESC cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg03467027 chr4:99064603 C4orf37 0.45 5.74 0.33 2.58e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2857078 0.654 rs4793083 chr17:42312973 C/T cg13607699 chr17:42295918 UBTF -0.76 -10.52 -0.54 7.64e-22 Red cell distribution width;Reticulocyte count; CESC cis rs8062405 0.754 rs149299 chr16:28485141 T/C cg05966235 chr16:28915196 ATP2A1 0.37 5.2 0.3 3.94e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01769284 chr22:24665573 CYTSA -0.44 -6.45 -0.37 5.4e-10 Gut microbiome composition (summer); CESC cis rs6570726 0.837 rs419991 chr6:145864212 C/T cg05347473 chr6:146136440 FBXO30 0.48 6.45 0.37 5.27e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4555082 0.834 rs2735826 chr14:105710866 G/A cg06808227 chr14:105710500 BRF1 -0.51 -5.81 -0.34 1.77e-8 Mean platelet volume;Platelet distribution width; CESC cis rs7191700 1.000 rs7191700 chr16:11406803 C/T cg00044050 chr16:11439710 C16orf75 0.47 5.46 0.32 1.07e-7 Multiple sclerosis; CESC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg21280719 chr6:42927975 GNMT -0.3 -6.81 -0.39 6.46e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg03351412 chr1:154909251 PMVK 0.68 9.11 0.49 2.15e-17 Prostate cancer; CESC cis rs9457247 1.000 rs430293 chr6:167404958 A/G cg23791538 chr6:167370224 RNASET2 -0.59 -8.42 -0.46 2.44e-15 Crohn's disease; CESC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg00074818 chr8:8560427 CLDN23 0.36 5.17 0.3 4.63e-7 Obesity-related traits; CESC cis rs1348850 0.874 rs952746 chr2:178306584 A/G cg22681709 chr2:178499509 PDE11A -0.4 -5.94 -0.34 9.14e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2180341 0.842 rs6569476 chr6:127553539 G/A cg27446573 chr6:127587934 RNF146 0.94 11.52 0.58 3.72e-25 Breast cancer; CESC cis rs3015497 0.527 rs2934668 chr14:51153525 C/T cg26011998 chr14:51135199 SAV1 -0.57 -6.43 -0.37 5.8e-10 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12746790 chr22:50683553 TUBGCP6 0.56 6.2 0.36 2.2e-9 Gut microbiome composition (summer); CESC cis rs9640161 0.659 rs7806429 chr7:150013393 A/G cg21361702 chr7:150065534 REPIN1 0.5 5.79 0.34 1.99e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs6496667 0.557 rs2601201 chr15:90958000 C/T cg22089800 chr15:90895588 ZNF774 0.5 6.38 0.36 8.03e-10 Rheumatoid arthritis; CESC cis rs4906332 1.000 rs78316803 chr14:103942863 A/G cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.49e-10 Coronary artery disease; CESC cis rs11997175 0.583 rs4386938 chr8:33673156 A/G ch.8.33884649F chr8:33765107 NA 0.59 8.05 0.44 2.87e-14 Body mass index; CESC cis rs7666738 0.579 rs7672718 chr4:98645122 A/G cg05340658 chr4:99064831 C4orf37 0.61 7.53 0.42 7.79e-13 Colonoscopy-negative controls vs population controls; CESC cis rs2898681 0.528 rs73814883 chr4:53728054 G/C cg00791764 chr4:53727839 RASL11B 0.53 5.36 0.31 1.78e-7 Optic nerve measurement (cup area); CESC cis rs10129255 0.518 rs8010020 chr14:107186255 A/G cg07958169 chr14:107095056 NA -0.54 -8.51 -0.46 1.3e-15 Kawasaki disease; CESC cis rs3093024 1.000 rs3093024 chr6:167532793 C/T cg23791538 chr6:167370224 RNASET2 -0.4 -5.17 -0.3 4.63e-7 Rheumatoid arthritis; CESC cis rs2463822 1.000 rs72921498 chr11:62113090 C/T cg06239285 chr11:62104954 ASRGL1 -0.92 -8.83 -0.48 1.43e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs4727027 0.933 rs4727028 chr7:148874666 A/G cg23158103 chr7:148848205 ZNF398 0.42 6.76 0.38 8.7e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7264396 1.000 rs224440 chr20:34159447 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.43 5.26 0.31 2.93e-7 Total cholesterol levels; CESC cis rs11758351 0.660 rs55643278 chr6:26222888 C/A cg01420254 chr6:26195488 NA 0.77 8.34 0.46 4.12e-15 Gout;Renal underexcretion gout; CESC cis rs8068544 0.818 rs7209012 chr17:40161323 C/T cg26502583 chr17:39992600 KLHL10;NT5C3L -0.76 -6.07 -0.35 4.34e-9 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs9308731 0.591 rs10199020 chr2:111946456 T/A cg04202892 chr2:111875749 ACOXL 0.41 5.74 0.33 2.53e-8 Chronic lymphocytic leukemia; CESC cis rs2066819 1.000 rs74673257 chr12:56638077 T/C cg26714650 chr12:56694279 CS -1.42 -10.05 -0.53 2.39e-20 Psoriasis vulgaris; CESC trans rs11039571 0.544 rs7947811 chr11:48167738 C/T cg15704280 chr7:45808275 SEPT13 -0.68 -6.68 -0.38 1.38e-10 D-dimer levels; CESC cis rs832540 0.931 rs832534 chr5:56213672 G/A cg24531977 chr5:56204891 C5orf35 -0.44 -5.49 -0.32 9.32e-8 Coronary artery disease; CESC trans rs11098499 0.644 rs34835603 chr4:120553428 C/T cg25214090 chr10:38739885 LOC399744 0.61 8.57 0.47 8.89e-16 Corneal astigmatism; CESC cis rs7267979 0.816 rs8115257 chr20:25207931 A/G cg08601574 chr20:25228251 PYGB 0.36 5.32 0.31 2.23e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs9400271 0.632 rs6930844 chr6:109590286 C/A cg01475377 chr6:109611718 NA -0.45 -7.01 -0.4 1.99e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs9611565 0.571 rs7364123 chr22:42216326 A/G cg06481639 chr22:41940642 POLR3H -0.46 -5.35 -0.31 1.91e-7 Vitiligo; CESC cis rs10779751 1.000 rs11121710 chr1:11313244 T/C cg08854313 chr1:11322531 MTOR 0.78 10.28 0.53 4.36e-21 Body mass index; CESC cis rs933688 1.000 rs985434 chr5:90744509 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 12.13 0.6 3.17e-27 Smoking behavior; CESC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg11644478 chr21:40555479 PSMG1 -0.79 -11.66 -0.58 1.23e-25 Cognitive function; CESC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg02725872 chr8:58115012 NA -0.37 -6.03 -0.35 5.44e-9 Developmental language disorder (linguistic errors); CESC cis rs8177179 0.904 rs1130459 chr3:133465283 A/G cg16262614 chr3:133464971 TF 0.38 7.59 0.42 5.42e-13 Iron status biomarkers (transferrin levels); CESC cis rs72945132 0.769 rs3781644 chr11:70190375 G/A cg14191688 chr11:70257035 CTTN 0.41 5.13 0.3 5.6e-7 Coronary artery disease; CESC trans rs877282 0.838 rs11253408 chr10:796374 T/C cg22713356 chr15:30763199 NA 1.32 13.47 0.64 7.47e-32 Uric acid levels; CESC cis rs9322193 0.847 rs868375 chr6:150166041 T/A cg09699651 chr6:150184138 LRP11 0.45 5.63 0.33 4.49e-8 Lung cancer; CESC cis rs34779708 0.931 rs12240347 chr10:35359475 A/G cg04310649 chr10:35416472 CREM -0.53 -6.43 -0.37 5.94e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs11711311 0.712 rs2271498 chr3:113334752 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.48 0.37 4.51e-10 IgG glycosylation; CESC cis rs959260 1.000 rs7221050 chr17:73393949 A/T cg12999837 chr17:73267436 MIF4GD -0.48 -5.65 -0.33 4.03e-8 Systemic lupus erythematosus; CESC cis rs10504229 0.817 rs58957714 chr8:58195864 G/A cg24829409 chr8:58192753 C8orf71 -0.75 -8.27 -0.45 6.38e-15 Developmental language disorder (linguistic errors); CESC cis rs832540 0.519 rs6450411 chr5:56265771 A/G cg24531977 chr5:56204891 C5orf35 -0.42 -5.25 -0.31 3.05e-7 Coronary artery disease; CESC cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg20503657 chr10:835505 NA 0.79 7.91 0.44 7.09e-14 Eosinophil percentage of granulocytes; CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg12419862 chr22:24373484 LOC391322 -0.92 -14.27 -0.66 1.19e-34 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg02034447 chr16:89574710 SPG7 0.51 6.56 0.37 2.88e-10 Multiple myeloma (IgH translocation); CESC cis rs3096299 0.566 rs4129126 chr16:89561475 A/C cg02034447 chr16:89574710 SPG7 0.49 5.96 0.34 7.85e-9 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10519709 chr1:204347359 NA 0.56 6.56 0.37 2.87e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.79 -8.68 -0.47 4.11e-16 Alzheimer's disease; CESC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03576123 chr11:487126 PTDSS2 -1.06 -10.99 -0.56 2.1e-23 Body mass index; CESC cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg07636037 chr3:49044803 WDR6 1.01 17.95 0.74 1.05e-47 Parkinson's disease; CESC cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg22875332 chr1:76189707 ACADM 0.63 7.42 0.41 1.59e-12 Blood metabolite levels;Acylcarnitine levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23152667 chr5:77072348 TBCA 0.45 6.09 0.35 3.93e-9 Gut microbiota (bacterial taxa); CESC cis rs8017423 0.967 rs2149655 chr14:90707246 T/C cg14092571 chr14:90743983 NA -0.58 -8.54 -0.46 1.04e-15 Mortality in heart failure; CESC cis rs6089584 0.527 rs927589 chr20:60606363 A/G cg06108461 chr20:60628389 TAF4 -0.62 -8.19 -0.45 1.14e-14 Body mass index; CESC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg22143856 chr6:28129313 ZNF389 0.42 5.26 0.31 2.91e-7 Parkinson's disease; CESC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.95 -15.09 -0.68 1.47e-37 Prudent dietary pattern; CESC cis rs80130819 0.688 rs2054902 chr12:48724778 A/C cg05342945 chr12:48394962 COL2A1 -0.5 -5.35 -0.31 1.9e-7 Prostate cancer; CESC trans rs1814175 0.765 rs1721990 chr11:49912154 G/C cg15704280 chr7:45808275 SEPT13 -1.03 -21.21 -0.79 4.77e-59 Height; CESC cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.558 rs66545149 chr12:38204694 A/G cg26384229 chr12:38710491 ALG10B 0.73 10.16 0.53 1.08e-20 Bladder cancer; CESC cis rs17539620 0.624 rs62432740 chr6:154836054 C/T cg17771515 chr6:154831774 CNKSR3 0.59 5.81 0.34 1.8e-8 Lipoprotein (a) levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01973725 chr5:80608537 RNU5E;RNU5D;ZCCHC9 -0.55 -6.36 -0.36 8.7e-10 Gut microbiome composition (summer); CESC cis rs1577917 1.000 rs1962716 chr6:86648436 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -5.9 -0.34 1.14e-8 Response to antipsychotic treatment; CESC cis rs7914558 0.966 rs10786724 chr10:104668942 A/G cg04362960 chr10:104952993 NT5C2 0.43 5.56 0.32 6.69e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs447 1.000 rs6977099 chr7:83762428 C/A cg22846510 chr7:83753280 SEMA3A -0.47 -5.76 -0.33 2.37e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs10771431 1.000 rs11611670 chr12:9385535 C/T cg00504896 chr12:9437009 LOC642846 -0.41 -5.49 -0.32 9.47e-8 Breast size; CESC cis rs112591243 0.570 rs2839340 chr21:47989804 C/T cg26904215 chr21:47823096 PCNT -0.8 -5.08 -0.3 7.13e-7 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18300819 chr6:88299852 ORC3L;RARS2 -0.47 -6.03 -0.35 5.58e-9 Ulcerative colitis; CESC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.77 0.38 8.38e-11 Bipolar disorder; CESC cis rs2302190 0.882 rs9911609 chr17:56673087 T/C cg25885038 chr17:56607967 SEPT4 -0.4 -5.43 -0.32 1.27e-7 Vitamin D levels; CESC cis rs17253792 0.749 rs45458197 chr14:56145018 A/T cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10304803 chr17:80771384 TBCD -0.59 -6.45 -0.37 5.19e-10 Gut microbiome composition (summer); CESC cis rs10129255 0.642 rs11624918 chr14:107120688 T/C cg07958169 chr14:107095056 NA -0.46 -6.52 -0.37 3.46e-10 Kawasaki disease; CESC cis rs16854884 0.580 rs6778791 chr3:143846398 C/T cg06585982 chr3:143692056 C3orf58 0.42 5.3 0.31 2.42e-7 Economic and political preferences (feminism/equality); CESC cis rs3747547 0.818 rs11790550 chr9:37935319 C/T cg13774184 chr9:37916125 SHB -0.54 -5.44 -0.32 1.21e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs7618501 0.602 rs2071206 chr3:50160109 G/A cg21659725 chr3:3221576 CRBN -0.47 -6.53 -0.37 3.4e-10 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14649924 chr1:10535034 PEX14 0.56 6.17 0.35 2.53e-9 Gut microbiome composition (summer); CESC cis rs916888 0.821 rs199512 chr17:44857352 T/C cg01570182 chr17:44337453 NA -0.87 -10.59 -0.55 4.47e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs5753618 0.554 rs5753648 chr22:31879465 A/G cg02404636 chr22:31891804 SFI1 0.41 5.28 0.31 2.73e-7 Colorectal cancer; CESC cis rs1461503 0.932 rs10790542 chr11:122838243 C/T cg27398637 chr11:122830231 C11orf63 -0.57 -8.68 -0.47 4.17e-16 Menarche (age at onset); CESC cis rs67478160 0.643 rs2223937 chr14:104286380 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.14 -0.4 8.85e-12 Schizophrenia; CESC cis rs16867321 0.507 rs2013577 chr2:181370505 C/T cg23363182 chr2:181467187 NA -0.42 -5.92 -0.34 9.91e-9 Obesity; CESC cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg05347473 chr6:146136440 FBXO30 0.72 9.12 0.49 1.9e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs5758659 0.819 rs134871 chr22:42652716 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.3 -5.28 -0.31 2.71e-7 Cognitive function; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg16132339 chr22:24313637 DDTL;DDT 0.4 5.99 0.35 6.79e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs8062405 1.000 rs62036624 chr16:28839930 G/T cg08761264 chr16:28874980 SH2B1 -0.47 -5.83 -0.34 1.64e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11039798 0.920 rs8186465 chr11:48796771 T/C cg15704280 chr7:45808275 SEPT13 0.71 6.44 0.37 5.59e-10 Axial length; CESC cis rs3126085 0.935 rs4595369 chr1:152248193 G/A cg03465714 chr1:152285911 FLG -0.46 -5.75 -0.33 2.42e-8 Atopic dermatitis; CESC cis rs7553864 0.574 rs6576867 chr1:87615796 A/T cg17420885 chr1:87600446 LOC339524 -0.53 -7.22 -0.41 5.44e-12 Smoking behavior; CESC cis rs10129255 0.500 rs8011115 chr14:107194530 T/C cg23076370 chr14:107095027 NA -0.61 -8.76 -0.47 2.31e-16 Kawasaki disease; CESC cis rs2730245 0.550 rs2657364 chr7:158683825 T/C cg14689365 chr7:158441557 NCAPG2 0.42 5.22 0.31 3.7e-7 Height; CESC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg18402987 chr7:1209562 NA 0.76 7.61 0.42 4.74e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2262909 0.745 rs1989120 chr19:22205528 T/C cg11619707 chr19:22235551 ZNF257 -0.32 -5.36 -0.31 1.8e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10341310 chr8:66582206 MTFR1 -0.63 -7.52 -0.42 8.4e-13 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02677328 chr6:52267982 PAQR8 -0.41 -6.64 -0.38 1.74e-10 Gambling; CESC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg00684032 chr4:1343700 KIAA1530 0.41 5.83 0.34 1.58e-8 Obesity-related traits; CESC cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg13770153 chr20:60521292 NA -0.51 -6.61 -0.38 2.08e-10 Body mass index; CESC cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg05340658 chr4:99064831 C4orf37 0.8 12.25 0.6 1.2e-27 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg07414643 chr4:187882934 NA 0.49 7.0 0.39 2.16e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg11752832 chr7:134001865 SLC35B4 0.5 6.33 0.36 1.03e-9 Mean platelet volume; CESC cis rs7539624 0.588 rs1892076 chr1:223899417 T/A cg10100437 chr1:223903862 CAPN2 0.45 5.94 0.34 8.77e-9 Schizophrenia; CESC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg23221052 chr5:179740743 GFPT2 -0.67 -9.14 -0.49 1.66e-17 Height; CESC cis rs9486715 0.838 rs9320127 chr6:96865358 G/A cg18709589 chr6:96969512 KIAA0776 0.44 6.26 0.36 1.59e-9 Headache; CESC cis rs7772486 0.790 rs2256998 chr6:146207657 A/C cg05347473 chr6:146136440 FBXO30 0.55 7.05 0.4 1.52e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs713587 0.646 rs34697209 chr2:25127394 A/G cg01884057 chr2:25150051 NA 0.33 6.34 0.36 9.84e-10 Body mass index in non-asthmatics; CESC cis rs12824058 0.831 rs4759451 chr12:130812739 G/A cg26677194 chr12:130822605 PIWIL1 0.51 6.72 0.38 1.13e-10 Menopause (age at onset); CESC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg25036284 chr2:26402008 FAM59B -0.57 -6.53 -0.37 3.25e-10 Gut microbiome composition (summer); CESC cis rs9837602 0.935 rs9875640 chr3:99729091 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.78 0.43 1.62e-13 Breast cancer; CESC cis rs10870270 1.000 rs4880246 chr10:133764064 C/T cg08754478 chr10:133766260 PPP2R2D -0.6 -7.71 -0.43 2.59e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs782590 0.967 rs4290693 chr2:55799991 C/G cg18811423 chr2:55921094 PNPT1 0.75 11.91 0.59 1.8e-26 Metabolic syndrome; CESC cis rs7615952 0.866 rs1976459 chr3:125647486 A/T cg05084668 chr3:125655381 ALG1L -0.51 -5.95 -0.34 8.56e-9 Blood pressure (smoking interaction); CESC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.86e-17 Tonsillectomy; CESC trans rs2727020 0.619 rs1164665 chr11:49295630 T/C cg03929089 chr4:120376271 NA 0.68 8.49 0.46 1.48e-15 Coronary artery disease; CESC cis rs2011503 0.882 rs751857 chr19:19602873 G/T cg11584989 chr19:19387371 SF4 0.62 7.13 0.4 9.66e-12 Bipolar disorder; CESC cis rs7623687 0.892 rs73088122 chr3:49432404 C/T cg19401529 chr3:49056140 DALRD3 0.61 5.39 0.31 1.53e-7 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CESC trans rs3008870 0.583 rs17497947 chr1:67457199 G/T cg19754094 chr2:74055942 STAMBP -0.62 -6.0 -0.35 6.49e-9 Lymphocyte percentage of white cells; CESC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg00166722 chr3:10149974 C3orf24 0.48 5.95 0.34 8.39e-9 Alzheimer's disease; CESC cis rs763121 0.853 rs5750677 chr22:39147715 C/T cg21395723 chr22:39101663 GTPBP1 0.46 5.97 0.34 7.51e-9 Menopause (age at onset); CESC cis rs12681288 0.823 rs2701905 chr8:1003482 T/C cg04851639 chr8:1020857 NA -0.34 -7.65 -0.43 3.67e-13 Schizophrenia; CESC cis rs3960554 0.808 rs78811105 chr7:75702795 G/A cg17325771 chr7:75508891 RHBDD2 -0.36 -5.37 -0.31 1.72e-7 Eotaxin levels; CESC cis rs524281 0.692 rs10896076 chr11:65840668 A/G cg14036092 chr11:66035641 RAB1B -0.6 -6.44 -0.37 5.56e-10 Electroencephalogram traits; CESC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg04315214 chr1:2043799 PRKCZ 0.63 11.01 0.56 1.78e-23 Height; CESC cis rs3809863 0.782 rs7220606 chr17:45374795 A/G cg25173405 chr17:45401733 C17orf57 -0.47 -6.19 -0.36 2.25e-9 Glaucoma (primary open-angle); CESC cis rs7267979 1.000 rs4815426 chr20:25405186 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.09 -0.74 3.57e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs4523957 0.620 rs9892754 chr17:2084565 G/T cg16513277 chr17:2031491 SMG6 -0.71 -10.17 -0.53 1.04e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17177017 chr17:74668252 NA -0.4 -6.12 -0.35 3.27e-9 Gambling; CESC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg06481639 chr22:41940642 POLR3H 0.6 5.97 0.34 7.49e-9 Vitiligo; CESC cis rs938554 0.542 rs7678287 chr4:10000501 A/G cg00071950 chr4:10020882 SLC2A9 0.61 7.08 0.4 1.28e-11 Blood metabolite levels; CESC cis rs6541297 1.000 rs6686054 chr1:230282853 C/T cg20703242 chr1:230279135 GALNT2 0.68 10.93 0.56 3.41e-23 Coronary artery disease; CESC cis rs11122272 0.735 rs2749699 chr1:231520279 A/C cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs9549260 0.564 rs9646110 chr13:41308301 A/T cg21288729 chr13:41239152 FOXO1 -0.59 -7.29 -0.41 3.5e-12 Red blood cell count; CESC cis rs2404602 0.647 rs12904149 chr15:77043652 A/C cg23625390 chr15:77176239 SCAPER -0.4 -5.2 -0.3 4e-7 Blood metabolite levels; CESC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg12963246 chr6:28129442 ZNF389 0.58 7.86 0.43 9.67e-14 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20263942 chr9:88714961 GOLM1 -0.53 -6.01 -0.35 6.22e-9 Gut microbiome composition (summer); CESC cis rs67311347 0.955 rs11711994 chr3:40391086 T/C cg09455208 chr3:40491958 NA 0.53 8.84 0.48 1.32e-16 Renal cell carcinoma; CESC cis rs1355223 0.583 rs2941044 chr11:34867444 A/C cg11058730 chr11:34937778 PDHX;APIP 0.83 12.78 0.62 1.78e-29 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs975210 0.556 rs2291986 chr15:70368432 C/T cg01666796 chr15:70364327 TLE3 0.41 5.11 0.3 6.22e-7 Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg25072359 chr17:41440525 NA 0.49 6.51 0.37 3.66e-10 Menopause (age at onset); CESC cis rs1949733 0.598 rs869602 chr4:8535371 G/T cg11789530 chr4:8429930 ACOX3 -0.62 -8.01 -0.44 3.62e-14 Response to antineoplastic agents; CESC cis rs2180341 1.000 rs9385419 chr6:127597591 A/G cg27446573 chr6:127587934 RNF146 1.07 15.98 0.7 1e-40 Breast cancer; CESC cis rs6912958 0.754 rs4707374 chr6:88255438 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.5 -0.37 3.97e-10 Monocyte percentage of white cells; CESC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg18016565 chr1:150552671 MCL1 -0.35 -5.82 -0.34 1.67e-8 Tonsillectomy; CESC trans rs11098499 0.909 rs9759478 chr4:120367998 G/A cg25214090 chr10:38739885 LOC399744 0.71 9.8 0.52 1.46e-19 Corneal astigmatism; CESC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg22549504 chr19:17448937 GTPBP3 0.52 5.82 0.34 1.7e-8 Systemic lupus erythematosus; CESC cis rs7267979 1.000 rs4815405 chr20:25317492 T/C cg08601574 chr20:25228251 PYGB -0.39 -5.52 -0.32 8.07e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs3741404 0.609 rs651855 chr11:63870810 T/C cg18225595 chr11:63971243 STIP1 0.52 6.77 0.38 8.2e-11 Platelet count; CESC cis rs4268898 0.662 rs72793213 chr2:24524725 A/G cg20701182 chr2:24300061 SF3B14 0.63 6.88 0.39 4.32e-11 Asthma; CESC cis rs12142240 0.698 rs72886911 chr1:46814352 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs2777491 0.915 rs7180418 chr15:41629502 A/C cg18705301 chr15:41695430 NDUFAF1 -0.61 -9.27 -0.49 6.62e-18 Ulcerative colitis; CESC cis rs9948 0.655 rs62156221 chr2:97410850 A/G cg01990225 chr2:97406019 LMAN2L -1.02 -7.83 -0.43 1.17e-13 Erectile dysfunction and prostate cancer treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06748078 chr4:1004703 FGFRL1 -0.6 -7.24 -0.41 4.86e-12 Gut microbiome composition (summer); CESC cis rs10838687 1.000 rs4752979 chr11:47339180 A/G cg25783544 chr11:47291846 MADD 0.58 7.22 0.41 5.57e-12 Proinsulin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18268492 chr10:99185986 PGAM1 0.6 6.73 0.38 1.07e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12129209 chr14:102276033 PPP2R5C -0.6 -7.09 -0.4 1.25e-11 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg25072359 chr17:41440525 NA 0.48 6.51 0.37 3.85e-10 Menopause (age at onset); CESC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg16325326 chr1:53192061 ZYG11B 0.89 14.76 0.67 2.21e-36 Monocyte count; CESC trans rs61931739 0.534 rs2636072 chr12:34062386 C/T cg26384229 chr12:38710491 ALG10B 0.52 6.96 0.39 2.64e-11 Morning vs. evening chronotype; CESC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg22535103 chr8:58192502 C8orf71 -0.94 -9.92 -0.52 6.46e-20 Developmental language disorder (linguistic errors); CESC cis rs367943 0.712 rs26969 chr5:112742436 A/G cg12552261 chr5:112820674 MCC 0.4 5.35 0.31 1.89e-7 Type 2 diabetes; CESC cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg25894440 chr7:65020034 NA -0.61 -5.3 -0.31 2.42e-7 Diabetic kidney disease; CESC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg04025307 chr7:1156635 C7orf50 0.54 9.5 0.5 1.35e-18 Longevity;Endometriosis; CESC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg09455208 chr3:40491958 NA 0.49 8.17 0.45 1.3e-14 Renal cell carcinoma; CESC trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg15704280 chr7:45808275 SEPT13 -0.9 -13.12 -0.63 1.2e-30 Height; CESC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg10351095 chr21:47802916 PCNT 0.49 6.82 0.39 6.08e-11 Testicular germ cell tumor; CESC cis rs34779708 1.000 rs12769189 chr10:35399668 A/G cg03585969 chr10:35415529 CREM 0.77 10.08 0.53 1.97e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs9467711 0.659 rs13195509 chr6:26463660 C/T cg21479132 chr6:26055353 NA 0.74 5.69 0.33 3.43e-8 Autism spectrum disorder or schizophrenia; CESC cis rs4481887 0.927 rs4581306 chr1:248476158 C/A cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs3740540 0.530 rs2362506 chr10:126290751 C/G cg04949429 chr10:126290192 LHPP 0.4 5.6 0.33 5.33e-8 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 6.14 0.35 3e-9 Electroencephalogram traits; CESC cis rs4727963 0.846 rs1404838 chr7:122696223 C/T cg03640110 chr7:122635026 TAS2R16 0.38 5.82 0.34 1.68e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs3008870 0.755 rs2815364 chr1:67498384 C/T cg02640540 chr1:67518911 SLC35D1 0.46 5.64 0.33 4.33e-8 Lymphocyte percentage of white cells; CESC cis rs3733585 0.699 rs7686538 chr4:9948077 C/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.96 -0.59 1.23e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg10541313 chr22:46663664 TTC38 0.61 5.23 0.31 3.38e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg06481639 chr22:41940642 POLR3H -0.61 -6.49 -0.37 4.09e-10 Vitiligo; CESC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg11766577 chr21:47581405 C21orf56 -0.46 -6.3 -0.36 1.21e-9 Testicular germ cell tumor; CESC cis rs644799 0.710 rs666398 chr11:95551136 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.77 10.82 0.55 8.02e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2594989 0.943 rs2244617 chr3:11503097 T/C cg00170343 chr3:11313890 ATG7 0.56 5.1 0.3 6.55e-7 Circulating chemerin levels; CESC cis rs9611565 0.694 rs202641 chr22:41833116 C/T cg03806693 chr22:41940476 POLR3H 1.08 14.48 0.66 2.06e-35 Vitiligo; CESC cis rs910316 0.789 rs175444 chr14:75601782 G/C cg16144293 chr14:75469539 EIF2B2 0.41 5.35 0.31 1.88e-7 Height; CESC cis rs7923609 0.967 rs10761758 chr10:65172747 A/T cg01631684 chr10:65280961 REEP3 -0.43 -5.32 -0.31 2.25e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs2439831 0.702 rs9989313 chr15:44152817 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.6 0.33 5.26e-8 Lung cancer in ever smokers; CESC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg08888203 chr3:10149979 C3orf24 0.48 6.08 0.35 4.18e-9 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27223663 chr16:2983543 FLYWCH1 -0.61 -7.32 -0.41 2.92e-12 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Tonsillectomy; CESC cis rs1048238 0.935 rs761760 chr1:16342419 A/G cg22431228 chr1:16359049 CLCNKA -0.52 -9.9 -0.52 7.22e-20 Systolic blood pressure; CESC cis rs9486715 0.867 rs9384585 chr6:96875664 C/T cg06623918 chr6:96969491 KIAA0776 0.91 14.05 0.65 6.83e-34 Headache; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02767759 chr16:30366751 CD2BP2 0.47 5.99 0.35 6.65e-9 Gut microbiota (bacterial taxa); CESC cis rs4481887 0.893 rs1339992 chr1:248509182 G/A cg00666640 chr1:248458726 OR2T12 0.35 6.02 0.35 5.85e-9 Common traits (Other); CESC cis rs8002861 0.875 rs11616803 chr13:44457109 A/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.47 -6.02 -0.35 5.84e-9 Leprosy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22829908 chr10:21814466 C10orf140 -0.59 -6.78 -0.38 7.65e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24489813 chr12:53574330 ZNF740;CSAD 0.55 6.43 0.37 5.75e-10 Gut microbiome composition (summer); CESC cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg24308560 chr3:49941425 MST1R -0.64 -9.19 -0.49 1.17e-17 Intelligence (multi-trait analysis); CESC cis rs6570726 0.935 rs384806 chr6:145814889 C/G cg05347473 chr6:146136440 FBXO30 0.5 6.71 0.38 1.15e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs3942852 0.774 rs2279823 chr11:48146092 T/C cg03929089 chr4:120376271 NA -0.57 -6.12 -0.35 3.4e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg04414720 chr1:150670196 GOLPH3L 0.56 7.34 0.41 2.56e-12 Melanoma; CESC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.56 6.6 0.38 2.27e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6121246 0.909 rs6058460 chr20:30363071 G/A cg13852791 chr20:30311386 BCL2L1 0.81 8.65 0.47 5.15e-16 Mean corpuscular hemoglobin; CESC trans rs7618501 0.633 rs4688689 chr3:50035542 C/T cg21659725 chr3:3221576 CRBN 0.5 6.96 0.39 2.63e-11 Intelligence (multi-trait analysis); CESC cis rs258892 0.895 rs9293450 chr5:72068476 G/A cg21869765 chr5:72125136 TNPO1 -0.42 -5.08 -0.3 7.12e-7 Small cell lung carcinoma; CESC cis rs629922 1.000 rs629922 chr11:114064825 C/T cg25009965 chr11:114031120 ZBTB16 -0.41 -5.33 -0.31 2.13e-7 Paneth cell defects in Crohn's disease; CESC cis rs6714710 0.603 rs17489454 chr2:98407350 C/T cg10020592 chr2:97779784 ANKRD36 -0.38 -5.12 -0.3 5.96e-7 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg07677032 chr17:61819896 STRADA 0.45 5.96 0.34 8.19e-9 Prudent dietary pattern; CESC cis rs6690583 0.943 rs1837329 chr1:85469614 G/A cg11262906 chr1:85462892 MCOLN2 -0.53 -5.9 -0.34 1.11e-8 Serum sulfate level; CESC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg21280719 chr6:42927975 GNMT -0.3 -7.07 -0.4 1.4e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7772486 0.875 rs7766463 chr6:146364453 A/G cg23711669 chr6:146136114 FBXO30 0.83 12.17 0.6 2.39e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg06420487 chr17:61919686 SMARCD2 0.46 5.53 0.32 7.63e-8 Height; CESC cis rs7568458 0.709 rs762684 chr2:85782023 G/A cg02493740 chr2:85810744 VAMP5 -0.57 -8.42 -0.46 2.41e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs2952156 0.920 rs1565920 chr17:37831613 G/A cg07936489 chr17:37558343 FBXL20 -0.58 -7.43 -0.42 1.48e-12 Asthma; CESC cis rs3814231 0.531 rs12773054 chr10:115476042 C/T cg24846397 chr10:115438155 CASP7 -0.32 -5.26 -0.31 2.96e-7 Vitiligo; CESC cis rs2635047 1.000 rs9304341 chr18:44670263 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.47 6.54 0.37 3.23e-10 Educational attainment; CESC cis rs858239 0.932 rs1637190 chr7:23269065 A/G cg23682824 chr7:23144976 KLHL7 0.44 5.84 0.34 1.51e-8 Cerebrospinal fluid biomarker levels; CESC cis rs4148883 0.898 rs4699726 chr4:100099513 T/C cg12011299 chr4:100065546 ADH4 0.41 5.76 0.33 2.39e-8 Alcohol dependence; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg13547551 chr9:133455399 LOC100272217;FUBP3 -0.59 -6.93 -0.39 3.18e-11 Subjective well-being; CESC cis rs76419734 0.510 rs2553456 chr4:106751028 T/C cg24545054 chr4:106630052 GSTCD;INTS12 -0.59 -5.96 -0.34 7.85e-9 Post bronchodilator FEV1; CESC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg11644478 chr21:40555479 PSMG1 1.04 17.66 0.74 1.16e-46 Cognitive function; CESC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg22800045 chr5:56110881 MAP3K1 -0.76 -8.67 -0.47 4.42e-16 Initial pursuit acceleration; CESC cis rs2267137 0.574 rs5752910 chr22:29803493 A/G cg07256473 chr22:29710276 RASL10A 0.38 5.5 0.32 9.13e-8 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs3780486 0.846 rs3780487 chr9:33139237 T/C cg20290983 chr6:43655470 MRPS18A 0.99 18.43 0.75 2.16e-49 IgG glycosylation; CESC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg12463550 chr7:65579703 CRCP -0.45 -5.77 -0.33 2.19e-8 Aortic root size; CESC cis rs9914988 0.943 rs4795467 chr17:27180784 C/T cg20469991 chr17:27169893 C17orf63 -0.51 -5.12 -0.3 5.81e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs10276381 0.786 rs10255700 chr7:28220228 C/T cg23620719 chr7:28220237 JAZF1 0.83 9.02 0.48 3.88e-17 Crohn's disease; CESC cis rs6546537 0.824 rs55864699 chr2:69803650 C/T cg10773587 chr2:69614142 GFPT1 -0.61 -7.44 -0.42 1.4e-12 Serum thyroid-stimulating hormone levels; CESC cis rs55728055 0.661 rs62239169 chr22:32042514 G/A cg01338084 chr22:32026380 PISD 1.26 8.24 0.45 8.13e-15 Age-related hearing impairment; CESC cis rs7084402 0.902 rs1346300 chr10:60287635 G/C cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs11718455 0.961 rs3846068 chr3:44029835 G/A cg08738300 chr3:44038990 NA 0.47 6.3 0.36 1.22e-9 Coronary artery disease; CESC cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg26597838 chr10:835615 NA 0.75 6.88 0.39 4.43e-11 Eosinophil percentage of granulocytes; CESC cis rs7801375 0.504 rs2058969 chr7:131560764 C/A cg26572488 chr7:132299669 PLXNA4 -0.46 -5.32 -0.31 2.17e-7 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg20891558 chr2:74357851 NA 0.81 11.98 0.59 1.05e-26 Gestational age at birth (maternal effect); CESC cis rs1691799 0.867 rs1168348 chr12:66757168 G/A cg16791601 chr12:66731901 HELB -0.78 -13.77 -0.65 6.86e-33 White blood cell count (basophil); CESC cis rs2742417 0.603 rs2531755 chr3:45772742 T/C cg04837898 chr3:45731254 SACM1L -0.47 -6.17 -0.35 2.54e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs11098499 0.863 rs9997631 chr4:120469995 C/G cg24375607 chr4:120327624 NA 0.42 5.16 0.3 4.82e-7 Corneal astigmatism; CESC cis rs7520050 0.966 rs11211208 chr1:46334256 A/C cg03146154 chr1:46216737 IPP -0.48 -6.18 -0.36 2.39e-9 Red blood cell count;Reticulocyte count; CESC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg14393609 chr7:65229607 NA -0.47 -6.56 -0.37 2.83e-10 Calcium levels; CESC cis rs67311347 1.000 rs2305522 chr3:40429358 A/G cg01475735 chr3:40494733 NA -0.41 -5.22 -0.31 3.64e-7 Renal cell carcinoma; CESC cis rs1185460 0.967 rs1177562 chr11:118949331 C/T cg01677386 chr11:118938358 VPS11 -0.43 -5.15 -0.3 5.05e-7 Coronary artery disease; CESC cis rs2380220 0.640 rs9320386 chr6:95994955 T/C cg15832292 chr6:96025679 MANEA 0.7 6.74 0.38 9.99e-11 Behavioural disinhibition (generation interaction); CESC cis rs4148883 0.675 rs116265877 chr4:100096896 G/A cg12011299 chr4:100065546 ADH4 0.66 9.76 0.51 1.98e-19 Alcohol dependence; CESC trans rs4424809 0.614 rs17078993 chr13:85572180 C/T cg05918002 chr17:5019452 ZNF232 -0.64 -6.06 -0.35 4.77e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4253772 0.678 rs9627281 chr22:46644168 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.57 6.67 0.38 1.45e-10 LDL cholesterol;Cholesterol, total; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01870456 chr13:111267991 CARKD -0.44 -6.52 -0.37 3.44e-10 Gambling; CESC cis rs12477438 0.520 rs11123764 chr2:99750677 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.48 0.69 6.26e-39 Chronic sinus infection; CESC cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.6 0.33 5.46e-8 Personality dimensions; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg00371891 chr19:4723959 DPP9 0.58 6.02 0.35 5.69e-9 Diastolic blood pressure; CESC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg22535103 chr8:58192502 C8orf71 -0.92 -9.13 -0.49 1.84e-17 Developmental language disorder (linguistic errors); CESC cis rs6424115 0.800 rs6665733 chr1:24200158 T/C cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg11764359 chr7:65958608 NA -0.84 -12.8 -0.62 1.53e-29 Aortic root size; CESC cis rs9300255 0.510 rs1790086 chr12:123672518 A/G cg05973401 chr12:123451056 ABCB9 0.51 5.75 0.33 2.51e-8 Neutrophil percentage of white cells; CESC cis rs7605827 0.930 rs13029846 chr2:15674686 T/C cg19274914 chr2:15703543 NA 0.33 5.76 0.33 2.28e-8 Educational attainment (years of education); CESC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg24829409 chr8:58192753 C8orf71 -0.65 -7.84 -0.43 1.13e-13 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.954 rs13113483 chr4:120309039 C/T cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs6963495 0.818 rs6943132 chr7:105166776 C/T cg02135003 chr7:105160482 PUS7 -0.55 -5.38 -0.31 1.62e-7 Bipolar disorder (body mass index interaction); CESC cis rs992157 0.710 rs6719789 chr2:219057810 G/T cg20019365 chr2:219134978 PNKD;AAMP -0.61 -8.31 -0.45 5.16e-15 Colorectal cancer; CESC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs12477438 0.520 rs2309581 chr2:99784292 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.97 -17.47 -0.73 5.51e-46 Chronic sinus infection; CESC cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.94e-9 Extrinsic epigenetic age acceleration; CESC cis rs5498 0.809 rs2228615 chr19:10403368 G/A cg10604476 chr19:10403908 ICAM5 0.45 6.36 0.36 8.97e-10 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs12477438 1.000 rs12477438 chr2:99841085 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.77 -9.03 -0.48 3.7e-17 Chronic sinus infection; CESC cis rs75477785 1.000 rs12405750 chr1:209977844 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.88 5.74 0.33 2.62e-8 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27498211 chr16:4588826 C16orf5 0.58 6.35 0.36 9.34e-10 Gut microbiome composition (summer); CESC cis rs2933343 0.630 rs75824035 chr3:128652985 T/C cg25356066 chr3:128598488 ACAD9 0.65 9.06 0.49 2.95e-17 IgG glycosylation; CESC cis rs9527 0.521 rs12259163 chr10:104961477 A/G cg04362960 chr10:104952993 NT5C2 0.44 5.44 0.32 1.24e-7 Arsenic metabolism; CESC cis rs3815700 0.920 rs10424732 chr19:33096487 C/T cg02997394 chr19:33096574 ANKRD27 0.75 7.44 0.42 1.44e-12 Eosinophilic esophagitis; CESC cis rs4332037 0.707 rs10268797 chr7:1873756 C/G cg23422044 chr7:1970798 MAD1L1 0.52 5.45 0.32 1.15e-7 Bipolar disorder; CESC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs2404602 0.735 rs283789 chr15:76777577 G/A cg23625390 chr15:77176239 SCAPER 0.41 5.86 0.34 1.35e-8 Blood metabolite levels; CESC cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg27286337 chr10:134555280 INPP5A 0.63 7.37 0.41 2.23e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg12386194 chr3:101231763 SENP7 -0.45 -5.53 -0.32 7.54e-8 Colorectal cancer; CESC cis rs711245 0.573 rs7570763 chr2:36800589 A/C cg01206211 chr2:36825736 FEZ2 -0.33 -5.3 -0.31 2.41e-7 Height; CESC trans rs9325144 0.671 rs7486919 chr12:38767997 A/G cg23762105 chr12:34175262 ALG10 0.48 6.27 0.36 1.49e-9 Morning vs. evening chronotype; CESC cis rs6460942 1.000 rs17274870 chr7:12406221 G/T cg10578991 chr7:12443926 VWDE -0.55 -5.84 -0.34 1.53e-8 Coronary artery disease; CESC cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 9.04 0.49 3.35e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs77956314 0.515 rs10850733 chr12:117380961 G/A cg25972092 chr12:117363249 FBXW8 0.55 6.19 0.36 2.28e-9 Subcortical brain region volumes;Hippocampal volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06494227 chr22:30752758 CCDC157;SF3A1 0.63 6.9 0.39 3.83e-11 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15394763 chr10:77054788 NA -0.45 -6.36 -0.36 8.85e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10463316 0.894 rs954341 chr5:150751855 G/A cg03212797 chr5:150827313 SLC36A1 -0.52 -6.83 -0.39 5.78e-11 Metabolite levels (Pyroglutamine); CESC cis rs910316 1.000 rs4903275 chr14:75512509 C/T cg08847533 chr14:75593920 NEK9 0.99 18.02 0.74 6.08e-48 Height; CESC cis rs3762637 1.000 rs7626861 chr3:122155196 T/C cg24169773 chr3:122142474 KPNA1 -0.54 -6.31 -0.36 1.2e-9 LDL cholesterol levels; CESC cis rs7089973 0.604 rs765174 chr10:116601888 C/T cg03647239 chr10:116582469 FAM160B1 0.43 5.35 0.31 1.94e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg07414643 chr4:187882934 NA 0.56 8.14 0.45 1.53e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg20476274 chr7:133979776 SLC35B4 0.68 10.07 0.53 2.09e-20 Mean platelet volume; CESC cis rs9916302 0.821 rs12938268 chr17:37572139 G/A cg15445000 chr17:37608096 MED1 0.4 6.35 0.36 9.2e-10 Glomerular filtration rate (creatinine); CESC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg09658497 chr7:2847517 GNA12 -0.42 -6.07 -0.35 4.38e-9 Height; CESC cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg10556349 chr10:835070 NA -0.52 -5.25 -0.31 3.17e-7 Eosinophil percentage of granulocytes; CESC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg13628971 chr7:2884303 GNA12 0.64 8.77 0.47 2.21e-16 Height; CESC cis rs524281 1.000 rs527897 chr11:65900777 C/T cg14036092 chr11:66035641 RAB1B -0.51 -5.81 -0.34 1.75e-8 Electroencephalogram traits; CESC trans rs7618501 1.000 rs60205400 chr3:49800272 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.5 0.46 1.36e-15 Intelligence (multi-trait analysis); CESC cis rs4654899 0.758 rs12137408 chr1:21282945 A/G cg05370193 chr1:21551575 ECE1 0.37 5.62 0.33 4.75e-8 Superior frontal gyrus grey matter volume; CESC cis rs9858542 1.000 rs11718165 chr3:49696797 A/G cg03060546 chr3:49711283 APEH -0.57 -6.65 -0.38 1.66e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs3749237 0.929 rs62260715 chr3:49829326 G/A cg03060546 chr3:49711283 APEH 0.66 7.27 0.41 3.99e-12 Resting heart rate; CESC cis rs2637266 0.846 rs2583051 chr10:78403542 T/C cg18941641 chr10:78392320 NA 0.41 7.58 0.42 5.75e-13 Pulmonary function; CESC cis rs2645694 0.533 rs2645681 chr4:77820949 G/A cg18351406 chr4:77819688 ANKRD56 0.55 6.89 0.39 4.12e-11 Emphysema distribution in smoking; CESC cis rs1008375 0.931 rs10939734 chr4:17570709 C/T cg02297831 chr4:17616191 MED28 0.5 6.1 0.35 3.84e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs752010 0.571 rs10890135 chr1:42054084 G/A cg06885757 chr1:42089581 HIVEP3 0.48 7.75 0.43 1.96e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg00166722 chr3:10149974 C3orf24 0.48 6.13 0.35 3.09e-9 Alzheimer's disease; CESC trans rs61931739 0.517 rs1844525 chr12:34103183 T/A cg26384229 chr12:38710491 ALG10B 0.59 8.18 0.45 1.17e-14 Morning vs. evening chronotype; CESC cis rs7147624 1.000 rs11848209 chr14:66022832 T/A cg03016385 chr14:66212404 NA -0.49 -5.09 -0.3 6.8e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs7953249 0.618 rs7954331 chr12:121398657 G/T cg02403541 chr12:121454288 C12orf43 -0.53 -6.9 -0.39 3.77e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs7072216 0.727 rs942807 chr10:100168219 G/A cg26618903 chr10:100175079 PYROXD2 -0.36 -5.45 -0.32 1.14e-7 Metabolite levels; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg12427896 chr2:111880694 BCL2L11 0.48 6.39 0.37 7.45e-10 Obesity-related traits; CESC cis rs73206853 0.841 rs16940933 chr12:111102574 C/A cg12870014 chr12:110450643 ANKRD13A 0.63 5.12 0.3 5.79e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9325144 0.534 rs1973293 chr12:38679575 C/T cg26384229 chr12:38710491 ALG10B 0.6 9.3 0.5 5.38e-18 Morning vs. evening chronotype; CESC cis rs6061231 0.556 rs6121571 chr20:60977323 T/G cg22633769 chr20:60982531 CABLES2 0.67 8.4 0.46 2.65e-15 Colorectal cancer; CESC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.5 -5.79 -0.33 2.02e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10465746 0.780 rs1952065 chr1:84464205 T/C cg10977910 chr1:84465055 TTLL7 0.53 7.18 0.4 7.12e-12 Obesity-related traits; CESC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg11494091 chr17:61959527 GH2 0.74 13.06 0.63 1.94e-30 Prudent dietary pattern; CESC cis rs1030877 0.557 rs2278501 chr2:105979506 C/T cg02079111 chr2:105885981 TGFBRAP1 -0.43 -6.38 -0.36 7.9e-10 Obesity-related traits; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg05215272 chr17:6899095 ALOX12 -0.39 -7.01 -0.4 1.95e-11 Tonsillectomy; CESC cis rs17376456 0.877 rs17316137 chr5:93456577 C/T cg21475434 chr5:93447410 FAM172A 0.81 7.47 0.42 1.14e-12 Diabetic retinopathy; CESC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg24768116 chr2:27665128 KRTCAP3 -0.27 -5.13 -0.3 5.7e-7 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25754926 chr6:7986689 MGC26597 -0.52 -6.09 -0.35 3.9e-9 Gut microbiome composition (summer); CESC cis rs7103648 0.695 rs6485758 chr11:47530024 G/A cg10504702 chr11:47789108 FNBP4 0.43 5.31 0.31 2.34e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs11825685 0.790 rs56657264 chr11:134543459 C/T cg06603561 chr11:134479413 NA -0.64 -5.39 -0.31 1.59e-7 IgG glycosylation; CESC cis rs7084402 0.967 rs1658443 chr10:60316926 G/T cg07615347 chr10:60278583 BICC1 0.61 9.59 0.51 7.04e-19 Refractive error; CESC cis rs2072732 0.861 rs6661908 chr1:2950334 C/T cg15211996 chr1:2936768 ACTRT2 0.33 5.88 0.34 1.23e-8 Plateletcrit; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10436540 chr17:4047319 ZZEF1;CYB5D2 0.5 6.64 0.38 1.75e-10 Systemic lupus erythematosus; CESC trans rs7980799 0.935 rs2389194 chr12:33529164 A/G cg26384229 chr12:38710491 ALG10B -0.48 -6.51 -0.37 3.68e-10 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs787274 1.000 rs9409123 chr9:115507165 G/A cg13803584 chr9:115635662 SNX30 0.65 5.5 0.32 8.78e-8 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs11039798 0.588 rs1847640 chr11:49004025 C/T cg03929089 chr4:120376271 NA 0.63 6.06 0.35 4.74e-9 Axial length; CESC cis rs3106136 0.609 rs11097406 chr4:95146042 C/T cg11021082 chr4:95130006 SMARCAD1 -0.47 -6.49 -0.37 4.28e-10 Capecitabine sensitivity; CESC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11764590 0.671 rs3800872 chr7:2110272 C/G cg11693508 chr17:37793320 STARD3 0.67 7.21 0.4 5.73e-12 Neuroticism; CESC cis rs9399135 0.967 rs6919862 chr6:135352443 C/A cg22676075 chr6:135203613 NA 0.51 7.27 0.41 4.07e-12 Red blood cell count; CESC cis rs9911578 1.000 rs10401050 chr17:56953786 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.16 0.3 4.87e-7 Intelligence (multi-trait analysis); CESC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg11644478 chr21:40555479 PSMG1 -0.8 -12.02 -0.59 7.25e-27 Cognitive function; CESC cis rs2882667 0.858 rs66839813 chr5:138442322 A/T cg04439458 chr5:138467593 SIL1 -0.39 -6.09 -0.35 3.9e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg02807482 chr3:125708958 NA -0.41 -5.39 -0.31 1.58e-7 Blood pressure (smoking interaction); CESC cis rs1707322 0.721 rs28641748 chr1:46212836 A/G cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC trans rs561341 1.000 rs4795668 chr17:30244554 G/A cg27661571 chr11:113659931 NA -0.69 -6.95 -0.39 2.88e-11 Hip circumference adjusted for BMI; CESC trans rs7615952 0.576 rs6780025 chr3:125815624 A/C cg07211511 chr3:129823064 LOC729375 -0.57 -6.31 -0.36 1.15e-9 Blood pressure (smoking interaction); CESC cis rs11838776 0.522 rs7318424 chr13:111021623 C/G cg06243866 chr13:111019493 COL4A2 0.34 5.09 0.3 6.65e-7 Coronary artery disease; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg16265552 chr3:113667068 ZDHHC23 0.59 6.11 0.35 3.47e-9 Diastolic blood pressure; CESC cis rs748404 0.697 rs572959 chr15:43550502 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.61 8.13 0.45 1.62e-14 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25377475 chr1:236030556 LYST 0.55 6.77 0.38 8.4e-11 Gut microbiome composition (summer); CESC cis rs7809950 0.773 rs62483722 chr7:107186349 C/T cg23024343 chr7:107201750 COG5 -0.41 -5.65 -0.33 4.03e-8 Coronary artery disease; CESC cis rs9359856 0.510 rs4235839 chr6:90472410 A/G cg13799429 chr6:90582589 CASP8AP2 0.7 7.91 0.44 6.85e-14 Bipolar disorder; CESC trans rs1814175 0.684 rs1827015 chr11:49585241 A/G cg15704280 chr7:45808275 SEPT13 -0.95 -14.94 -0.68 5.15e-37 Height; CESC trans rs7911712 0.515 rs2487504 chr10:45254830 C/T cg12743970 chr17:64536520 PRKCA 0.63 6.12 0.35 3.36e-9 Emphysema-related traits; CESC cis rs72634258 0.796 rs4369247 chr1:8168993 C/T cg00042356 chr1:8021962 PARK7 -0.48 -5.27 -0.31 2.88e-7 Inflammatory bowel disease; CESC cis rs73019876 0.869 rs2158107 chr19:22151345 T/G cg11619707 chr19:22235551 ZNF257 -0.28 -5.14 -0.3 5.26e-7 Testicular germ cell tumor; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg03148428 chr7:156433416 C7orf13;RNF32 0.42 6.03 0.35 5.49e-9 Breast cancer;Type 2 diabetes; CESC cis rs3026101 0.624 rs1806219 chr17:5288073 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.89 0.34 1.19e-8 Body mass index; CESC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg05564831 chr3:52568323 NT5DC2 0.44 6.58 0.37 2.57e-10 Bipolar disorder; CESC cis rs7264396 0.563 rs2066066 chr20:34329359 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.86 0.39 4.77e-11 Total cholesterol levels; CESC cis rs2415984 0.579 rs61993339 chr14:46969266 G/A cg14871534 chr14:47121158 RPL10L -0.35 -5.23 -0.31 3.52e-7 Number of children ever born; CESC cis rs7122539 0.506 rs7944999 chr11:66687863 A/G cg24851651 chr11:66362959 CCS 0.4 5.78 0.33 2.08e-8 HIV-1 susceptibility; CESC cis rs10045504 0.502 rs72746031 chr5:38743161 G/A cg15396434 chr5:38725168 NA -0.73 -6.85 -0.39 5.24e-11 Night sleep phenotypes; CESC cis rs9581857 0.547 rs9579086 chr13:28058537 T/A cg01674679 chr13:27998804 GTF3A -0.62 -5.1 -0.3 6.52e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs561341 0.714 rs473535 chr17:30312365 A/G cg00745463 chr17:30367425 LRRC37B -0.77 -6.94 -0.39 2.98e-11 Hip circumference adjusted for BMI; CESC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg19468946 chr17:37922297 IKZF3 0.41 5.36 0.31 1.81e-7 Glomerular filtration rate (creatinine); CESC cis rs7264396 0.563 rs2066066 chr20:34329359 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.88e-22 Total cholesterol levels; CESC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg22133161 chr19:49891603 CCDC155 0.45 5.04 0.3 8.8e-7 Multiple sclerosis; CESC cis rs4555082 0.957 rs2816609 chr14:105720803 A/C cg27165867 chr14:105738592 BRF1 -0.46 -5.56 -0.32 6.6e-8 Mean platelet volume;Platelet distribution width; CESC cis rs2228479 0.717 rs1061647 chr16:89806063 G/C cg14709524 chr16:89940631 TCF25 0.9 6.47 0.37 4.72e-10 Skin colour saturation; CESC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.74 6.19 0.36 2.23e-9 Platelet count; CESC cis rs9630089 0.746 rs10882873 chr10:98966485 A/G cg25902810 chr10:99078978 FRAT1 -0.53 -7.45 -0.42 1.29e-12 Neutrophil percentage of white cells; CESC cis rs60871478 0.947 rs62432255 chr7:804219 G/A cg05535760 chr7:792225 HEATR2 0.85 10.63 0.55 3.21e-22 Cerebrospinal P-tau181p levels; CESC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.54 0.32 7.15e-8 Electroencephalogram traits; CESC cis rs17401966 0.838 rs1013952 chr1:10319247 G/A cg15208524 chr1:10270712 KIF1B 0.39 5.13 0.3 5.5e-7 Hepatocellular carcinoma; CESC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg18876405 chr7:65276391 NA 0.55 7.39 0.41 1.98e-12 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09115837 chr10:79541592 NA -0.73 -8.15 -0.45 1.48e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26422153 chr6:47277743 TNFRSF21 0.6 7.07 0.4 1.39e-11 Gut microbiome composition (summer); CESC cis rs7528419 1.000 rs12740374 chr1:109817590 G/T cg00908766 chr1:109817496 CELSR2 -0.46 -6.25 -0.36 1.63e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09796886 chr4:39640558 C4orf34 -0.43 -6.02 -0.35 5.88e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11098499 0.863 rs3775848 chr4:120447724 C/T cg24375607 chr4:120327624 NA 0.43 5.22 0.31 3.68e-7 Corneal astigmatism; CESC cis rs6754311 0.517 rs1469996 chr2:136542560 A/G cg07169764 chr2:136633963 MCM6 0.99 12.59 0.61 8.12e-29 Mosquito bite size; CESC cis rs7927592 0.913 rs67947146 chr11:68314980 C/T cg20283391 chr11:68216788 NA -0.61 -7.36 -0.41 2.26e-12 Total body bone mineral density; CESC cis rs916888 0.779 rs430685 chr17:44859148 T/C cg17911788 chr17:44343683 NA 0.53 7.17 0.4 7.3e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4930103 0.935 rs2071094 chr11:2021164 G/T cg23202291 chr11:1979235 NA 0.35 5.04 0.3 8.44e-7 DNA methylation (parent-of-origin);DNA methylation (variation); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26035463 chr12:117627651 FBXO21 -0.45 -6.26 -0.36 1.57e-9 Gambling; CESC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.78 0.33 2.09e-8 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10047026 chr17:4613992 ARRB2 0.55 6.19 0.36 2.3e-9 Gut microbiome composition (summer); CESC cis rs2408955 0.521 rs7301003 chr12:48550227 A/G cg04545296 chr12:48745243 ZNF641 0.34 5.81 0.34 1.76e-8 Glycated hemoglobin levels; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg02510453 chr4:152020490 RPS3A 0.48 6.27 0.36 1.43e-9 Recombination measurement; CESC cis rs10751667 0.666 rs10902248 chr11:957742 A/G cg01483505 chr11:975446 AP2A2 0.37 5.05 0.3 8.3e-7 Alzheimer's disease (late onset); CESC cis rs3768617 0.510 rs10752896 chr1:183068516 A/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.23 0.66 1.55e-34 Fuchs's corneal dystrophy; CESC cis rs3204270 0.684 rs62080212 chr17:79642500 G/A cg26965718 chr17:79658957 HGS -0.73 -5.61 -0.33 5.17e-8 Dental caries; CESC cis rs742320 0.756 rs4984925 chr16:839996 T/C cg03433313 chr16:819064 MIR662 -0.48 -6.19 -0.36 2.27e-9 Mean corpuscular volume; CESC cis rs4563143 0.514 rs73029079 chr19:29294903 A/G cg14983838 chr19:29218262 NA 0.5 5.52 0.32 8.22e-8 Methadone dose in opioid dependence; CESC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.81 0.34 1.81e-8 Personality dimensions; CESC cis rs710216 0.917 rs2297977 chr1:43415288 G/T cg22176566 chr1:43424700 SLC2A1 0.51 5.69 0.33 3.29e-8 Red cell distribution width; CESC cis rs2276314 0.857 rs8087539 chr18:33631537 C/T cg19628046 chr18:33552617 C18orf21 0.53 5.97 0.34 7.5e-9 Endometriosis;Drug-induced torsades de pointes; CESC cis rs524023 0.874 rs519090 chr11:64456240 G/C cg19131476 chr11:64387923 NRXN2 -0.33 -5.05 -0.3 8.13e-7 Urate levels in obese individuals; CESC cis rs6942756 1.000 rs6942756 chr7:128886821 T/G cg02491457 chr7:128862824 NA -0.68 -9.81 -0.52 1.35e-19 White matter hyperintensity burden; CESC cis rs2439831 0.850 rs8032649 chr15:44134922 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.67 -7.47 -0.42 1.15e-12 Lung cancer in ever smokers; CESC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg19163074 chr7:65112434 INTS4L2 0.46 5.57 0.32 6.37e-8 Aortic root size; CESC cis rs7927592 0.956 rs7102273 chr11:68385579 T/C cg16797656 chr11:68205561 LRP5 0.38 5.33 0.31 2.12e-7 Total body bone mineral density; CESC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg07701084 chr6:150067640 NUP43 0.45 6.1 0.35 3.75e-9 Lung cancer; CESC cis rs9948 0.867 rs62152860 chr2:97516818 C/A cg01990225 chr2:97406019 LMAN2L -0.76 -5.41 -0.32 1.44e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs933688 1.000 rs933688 chr5:90762748 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.01 12.83 0.62 1.25e-29 Smoking behavior; CESC cis rs2288073 0.965 rs10192600 chr2:24396680 A/G cg06627628 chr2:24431161 ITSN2 -0.73 -8.37 -0.46 3.41e-15 Venous thromboembolism (SNP x SNP interaction); CESC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg23161317 chr6:28129485 ZNF389 0.4 5.55 0.32 7.03e-8 Parkinson's disease; CESC trans rs12681287 0.511 rs7839601 chr8:87503839 G/C cg27317242 chr8:23145699 R3HCC1 -0.53 -6.35 -0.36 9.05e-10 Caudate activity during reward; CESC cis rs6500602 0.963 rs7201012 chr16:4480682 C/G cg08645402 chr16:4508243 NA 0.42 6.43 0.37 6.09e-10 Schizophrenia; CESC cis rs7605378 0.688 rs769961 chr2:200712141 C/A cg23649088 chr2:200775458 C2orf69 0.58 7.08 0.4 1.32e-11 Osteoporosis; CESC cis rs4975709 0.838 rs4975753 chr5:1880865 T/C cg15595755 chr5:1867978 NA 0.46 7.15 0.4 8.29e-12 Cardiovascular disease risk factors; CESC cis rs11190604 1.000 rs3793706 chr10:102269085 A/C cg07080220 chr10:102295463 HIF1AN -0.67 -6.28 -0.36 1.38e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs4423214 0.921 rs11603330 chr11:71153459 C/A cg05163923 chr11:71159392 DHCR7 0.82 11.52 0.58 3.73e-25 Vitamin D levels; CESC cis rs6912958 0.712 rs2787927 chr6:88412786 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -5.98 -0.34 7.17e-9 Monocyte percentage of white cells; CESC cis rs9399135 0.967 rs59329760 chr6:135342437 G/A cg22676075 chr6:135203613 NA 0.51 7.35 0.41 2.44e-12 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12534480 chr22:43582739 TTLL12 0.59 6.76 0.38 8.74e-11 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs4821809 chr22:39065743 G/C cg06544989 chr22:39130855 UNC84B 0.49 8.38 0.46 3.04e-15 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27161463 chr11:118123074 MPZL3 -0.45 -6.2 -0.36 2.1e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2315504 0.509 rs2240076 chr17:39035615 C/T cg05063374 chr17:38953512 KRT28 -0.39 -5.67 -0.33 3.69e-8 Height; CESC cis rs3820928 0.709 rs10178202 chr2:227914561 C/T cg11843606 chr2:227700838 RHBDD1 -0.49 -5.84 -0.34 1.51e-8 Pulmonary function; CESC cis rs7568458 0.684 rs1048739 chr2:85764968 T/G cg02493740 chr2:85810744 VAMP5 -0.57 -8.34 -0.46 4.23e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs6754311 0.517 rs1865452 chr2:136539330 C/T cg07169764 chr2:136633963 MCM6 0.98 12.46 0.61 2.27e-28 Mosquito bite size; CESC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs8103278 0.507 rs522769 chr19:46284520 G/A cg06577658 chr19:46296270 DMWD 0.43 5.2 0.3 4.02e-7 Coronary artery disease; CESC cis rs2279817 1.000 rs2279815 chr1:18022066 G/T cg21791023 chr1:18019539 ARHGEF10L 0.59 8.48 0.46 1.57e-15 Neuroticism; CESC cis rs561341 0.660 rs7406043 chr17:30220152 C/G cg13647721 chr17:30228624 UTP6 0.61 5.73 0.33 2.74e-8 Hip circumference adjusted for BMI; CESC cis rs4969178 0.965 rs8077859 chr17:76386335 C/T cg05887092 chr17:76393375 PGS1 0.57 8.87 0.48 1.08e-16 HDL cholesterol levels; CESC cis rs6866344 0.697 rs11743893 chr5:178125194 C/T cg10224037 chr5:178157518 ZNF354A 0.59 6.79 0.38 7.51e-11 Neutrophil percentage of white cells; CESC cis rs763121 0.962 rs2071887 chr22:38879010 A/T cg06544989 chr22:39130855 UNC84B 0.41 6.98 0.39 2.41e-11 Menopause (age at onset); CESC cis rs9443189 0.901 rs2038625 chr6:76560968 G/A cg01950844 chr6:76311363 SENP6 -0.59 -6.22 -0.36 1.88e-9 Prostate cancer; CESC cis rs11098499 0.954 rs10031483 chr4:120422636 T/C cg09307838 chr4:120376055 NA 0.93 13.08 0.63 1.67e-30 Corneal astigmatism; CESC cis rs28489187 0.597 rs10489513 chr1:85855622 C/T cg16011679 chr1:85725395 C1orf52 -0.42 -5.11 -0.3 6.15e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs6502050 0.805 rs8082653 chr17:80162382 G/A cg23985595 chr17:80112537 CCDC57 -0.4 -6.48 -0.37 4.35e-10 Life satisfaction; CESC cis rs10191773 0.535 rs56048537 chr2:113078467 G/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.62 -6.8 -0.39 7.11e-11 Yeast infection; CESC cis rs6665290 0.935 rs1929862 chr1:227199718 G/A cg10327440 chr1:227177885 CDC42BPA -1.22 -32.32 -0.89 6.28e-94 Myeloid white cell count; CESC cis rs6835098 0.828 rs28612521 chr4:174085294 G/A cg08422745 chr4:174089978 GALNT7 -0.84 -12.18 -0.6 2.12e-27 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.05 0.3 8.14e-7 Personality dimensions; CESC cis rs6500602 0.701 rs4786500 chr16:4525265 A/G cg08645402 chr16:4508243 NA -0.36 -5.29 -0.31 2.53e-7 Schizophrenia; CESC cis rs4243830 0.522 rs10864614 chr1:6596008 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.98 -9.97 -0.52 4.22e-20 Body mass index; CESC cis rs2299587 0.662 rs6586671 chr8:17776084 T/C cg08627089 chr8:17753878 FGL1 -0.39 -5.2 -0.3 3.96e-7 Economic and political preferences; CESC cis rs6500602 0.893 rs4786489 chr16:4485527 G/A cg08645402 chr16:4508243 NA 0.37 5.29 0.31 2.56e-7 Schizophrenia; CESC cis rs4974559 0.947 rs28540746 chr4:1352954 G/A cg02980000 chr4:1222292 CTBP1 0.73 6.79 0.38 7.37e-11 Systolic blood pressure; CESC cis rs2180341 0.855 rs9385422 chr6:127716457 C/T cg24812749 chr6:127587940 RNF146 0.83 11.75 0.59 6.25e-26 Breast cancer; CESC cis rs7561273 0.586 rs7589717 chr2:24357463 G/A cg20701182 chr2:24300061 SF3B14 0.46 6.01 0.35 6.27e-9 Quantitative traits; CESC cis rs6460942 0.630 rs62451487 chr7:12390464 G/A cg20607287 chr7:12443886 VWDE -0.61 -6.64 -0.38 1.82e-10 Coronary artery disease; CESC cis rs826838 1.000 rs1719830 chr12:39096992 T/G cg26384229 chr12:38710491 ALG10B -0.62 -9.94 -0.52 5.53e-20 Heart rate; CESC cis rs10504073 0.647 rs28685207 chr8:50003484 A/G cg00325661 chr8:49890786 NA 0.51 7.78 0.43 1.65e-13 Blood metabolite ratios; CESC cis rs7424096 0.613 rs72873859 chr2:37246738 T/G cg14987922 chr2:37194071 STRN 0.48 5.2 0.3 4e-7 High light scatter reticulocyte percentage of red cells; CESC cis rs9457247 0.624 rs9457260 chr6:167466665 C/T cg23791538 chr6:167370224 RNASET2 -0.52 -6.87 -0.39 4.45e-11 Crohn's disease; CESC cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.35 0.5 3.84e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs7772486 0.790 rs3923579 chr6:146230232 C/G cg23711669 chr6:146136114 FBXO30 -0.94 -13.73 -0.64 9.31e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs2880765 0.835 rs4340287 chr15:86043737 A/G cg19183879 chr15:85880815 NA -0.25 -5.18 -0.3 4.31e-7 Coronary artery disease; CESC cis rs6942756 0.531 rs7811141 chr7:128908273 C/G cg02491457 chr7:128862824 NA 0.48 6.85 0.39 5.14e-11 White matter hyperintensity burden; CESC cis rs7680126 0.596 rs12511337 chr4:10311972 A/G cg11266682 chr4:10021025 SLC2A9 0.41 5.34 0.31 2.05e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg00409905 chr10:38381863 ZNF37A -0.47 -6.33 -0.36 1.04e-9 Extrinsic epigenetic age acceleration; CESC cis rs367943 0.673 rs7708084 chr5:112732692 G/T cg12552261 chr5:112820674 MCC 0.38 5.14 0.3 5.32e-7 Type 2 diabetes; CESC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg08027265 chr7:2291960 NA -0.34 -5.23 -0.31 3.44e-7 Schizophrenia; CESC trans rs7246657 0.943 rs7255407 chr19:37933936 G/A cg01833234 chr11:6592585 DNHD1 0.52 6.0 0.35 6.5e-9 Coronary artery calcification; CESC cis rs7582720 1.000 rs72936862 chr2:203786812 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs1814175 0.904 rs1846289 chr11:49620253 G/A cg03929089 chr4:120376271 NA -0.88 -13.63 -0.64 2.05e-32 Height; CESC cis rs7274811 0.711 rs184110 chr20:31981432 G/A cg21523528 chr20:32077966 CBFA2T2 -0.43 -5.07 -0.3 7.53e-7 Height; CESC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.48e-10 Parkinson's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17378273 chr11:45169082 PRDM11 0.39 6.0 0.35 6.39e-9 Gambling; CESC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg12463550 chr7:65579703 CRCP 0.5 6.42 0.37 6.17e-10 Aortic root size; CESC cis rs6912958 0.712 rs9444525 chr6:88324142 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -5.57 -0.32 6.14e-8 Monocyte percentage of white cells; CESC cis rs5753618 0.504 rs9609297 chr22:31893731 G/T cg13145458 chr22:31556086 RNF185 -0.46 -5.25 -0.31 3.09e-7 Colorectal cancer; CESC cis rs2832191 0.646 rs2832210 chr21:30508723 T/G cg24692254 chr21:30365293 RNF160 -0.61 -7.72 -0.43 2.35e-13 Dental caries; CESC cis rs3749237 1.000 rs11710675 chr3:49751900 C/A cg03060546 chr3:49711283 APEH 0.64 7.48 0.42 1.09e-12 Resting heart rate; CESC cis rs7267979 0.744 rs6050464 chr20:25209299 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.72 12.0 0.59 8.92e-27 Liver enzyme levels (alkaline phosphatase); CESC cis rs2228479 0.702 rs62053702 chr16:89860688 G/T cg06558623 chr16:89946397 TCF25 1.18 9.47 0.5 1.65e-18 Skin colour saturation; CESC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.24 -0.41 4.79e-12 Developmental language disorder (linguistic errors); CESC cis rs10882165 0.547 rs2104631 chr10:94955827 G/C cg00992348 chr10:94926053 NA -0.31 -5.47 -0.32 1.04e-7 Refractive error; CESC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg22920501 chr2:26401640 FAM59B -0.86 -10.87 -0.56 5.47e-23 Gut microbiome composition (summer); CESC cis rs701145 0.617 rs7426835 chr3:154049539 C/T cg16511985 chr3:153974050 SGEF 0.36 5.14 0.3 5.33e-7 Coronary artery disease; CESC cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg12698349 chr2:225449008 CUL3 -0.62 -8.93 -0.48 7.53e-17 IgE levels in asthmatics (D.p. specific); CESC cis rs5758659 0.653 rs133383 chr22:42473603 C/T cg15557168 chr22:42548783 NA -0.48 -7.52 -0.42 8.34e-13 Cognitive function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22478328 chr22:32340140 C22orf24;YWHAH 0.49 6.4 0.37 7.09e-10 Gut microbiota (bacterial taxa); CESC cis rs2243480 1.000 rs4718309 chr7:65627764 G/C cg13147721 chr7:65941812 NA 0.97 9.19 0.49 1.2e-17 Diabetic kidney disease; CESC cis rs7945705 0.902 rs7930026 chr11:9013639 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.46 7.55 0.42 6.89e-13 Hemoglobin concentration; CESC cis rs4566357 0.615 rs12474622 chr2:227912793 A/G cg05526886 chr2:227700861 RHBDD1 -0.47 -6.28 -0.36 1.35e-9 Coronary artery disease; CESC cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg11952622 chr19:58962976 ZNF324B 0.46 6.13 0.35 3.11e-9 Uric acid clearance; CESC cis rs2243480 0.831 rs7806717 chr7:65393174 A/G cg13147721 chr7:65941812 NA 0.85 8.1 0.45 2e-14 Diabetic kidney disease; CESC cis rs963731 0.649 rs10153761 chr2:39262068 C/T cg04010122 chr2:39346883 SOS1 -0.74 -5.44 -0.32 1.19e-7 Corticobasal degeneration; CESC cis rs9291683 0.679 rs2241483 chr4:10099831 A/G cg00071950 chr4:10020882 SLC2A9 -0.57 -9.11 -0.49 2.11e-17 Bone mineral density; CESC cis rs738322 0.935 rs2413503 chr22:38568944 A/T cg25457927 chr22:38595422 NA -0.29 -5.52 -0.32 8.22e-8 Cutaneous nevi; CESC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg02725872 chr8:58115012 NA -0.41 -5.49 -0.32 9.22e-8 Developmental language disorder (linguistic errors); CESC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg10351095 chr21:47802916 PCNT -0.5 -6.82 -0.39 6.04e-11 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27657525 chr19:30432971 C19orf2 0.53 6.55 0.37 3.04e-10 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.57 -0.32 6.1e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs116095464 0.558 rs10057299 chr5:242135 C/T cg10591111 chr5:226296 SDHA -0.52 -6.38 -0.36 7.94e-10 Breast cancer; CESC cis rs9457247 0.663 rs9457257 chr6:167440736 G/A cg07741184 chr6:167504864 NA 0.34 6.01 0.35 6.21e-9 Crohn's disease; CESC cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.6 0.33 5.46e-8 Personality dimensions; CESC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.45 -0.37 5.39e-10 Total body bone mineral density; CESC cis rs2075371 0.611 rs12531769 chr7:134016899 C/G cg20476274 chr7:133979776 SLC35B4 0.58 7.82 0.43 1.23e-13 Mean platelet volume; CESC trans rs9325144 0.560 rs11183046 chr12:38655270 A/T cg23762105 chr12:34175262 ALG10 0.48 6.31 0.36 1.15e-9 Morning vs. evening chronotype; CESC cis rs77741769 0.507 rs11065264 chr12:121218380 T/G cg02419362 chr12:121203948 SPPL3 0.35 5.61 0.33 5e-8 Mean corpuscular volume; CESC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg09359103 chr1:154839909 KCNN3 -0.66 -12.34 -0.6 5.93e-28 Prostate cancer; CESC cis rs2760061 0.626 rs672907 chr1:228120345 G/A cg01973587 chr1:228161476 NA 0.38 5.93 0.34 9.18e-9 Diastolic blood pressure; CESC cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg21361702 chr7:150065534 REPIN1 0.47 5.54 0.32 7.34e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs735860 0.726 rs209518 chr6:53208016 C/A cg10236188 chr6:53219634 NA 0.35 5.27 0.31 2.79e-7 Glaucoma; CESC cis rs9584850 0.609 rs7983408 chr13:99155593 G/C cg20750642 chr13:99100586 FARP1 -0.37 -5.24 -0.31 3.29e-7 Neuroticism; CESC cis rs35955747 0.633 rs7287937 chr22:32020745 G/A cg25791279 chr22:32026902 PISD -0.49 -5.95 -0.34 8.57e-9 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg16145915 chr7:1198662 ZFAND2A -0.49 -6.2 -0.36 2.12e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1483890 0.642 rs1010315 chr3:69402165 C/T cg22125112 chr3:69402811 FRMD4B 0.38 5.1 0.3 6.48e-7 Resting heart rate; CESC cis rs8016982 0.674 rs11850714 chr14:81662993 C/G cg01989461 chr14:81687754 GTF2A1 0.75 11.64 0.58 1.4e-25 Schizophrenia; CESC cis rs10754283 0.557 rs1215511 chr1:90087543 C/A cg21401794 chr1:90099060 LRRC8C 0.56 7.81 0.43 1.31e-13 Amyotrophic lateral sclerosis (sporadic); CESC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg17718321 chr1:152188247 HRNR -0.54 -8.84 -0.48 1.39e-16 Inflammatory skin disease; CESC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.28 0.31 2.75e-7 Menopause (age at onset); CESC cis rs2688608 0.588 rs10128205 chr10:75469648 C/G cg23231163 chr10:75533350 FUT11 -0.36 -5.43 -0.32 1.28e-7 Inflammatory bowel disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09366641 chr1:153643528 ILF2 -0.46 -6.62 -0.38 1.93e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4803468 1.000 rs10409485 chr19:41920765 C/T cg14132834 chr19:41945861 ATP5SL 0.63 7.78 0.43 1.58e-13 Height; CESC cis rs1008375 0.606 rs6828925 chr4:17561139 C/T cg16339924 chr4:17578868 LAP3 0.55 7.0 0.4 2.09e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg04450456 chr4:17643702 FAM184B 0.39 5.56 0.32 6.7e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2455799 0.613 rs1976479 chr3:15729714 C/G cg16303742 chr3:15540471 COLQ -0.38 -5.8 -0.34 1.88e-8 Mean platelet volume; CESC cis rs1348850 0.567 rs3821006 chr2:178537694 G/A cg23306229 chr2:178417860 TTC30B 0.53 6.97 0.39 2.55e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs57506017 0.606 rs7785087 chr7:12257549 A/G cg23422036 chr7:12250390 TMEM106B 0.38 5.11 0.3 6.06e-7 Neuroticism; CESC cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg15506890 chr2:3487001 NA -0.48 -6.12 -0.35 3.33e-9 Neurofibrillary tangles; CESC cis rs10861342 0.892 rs10459207 chr12:105531072 C/T cg23923672 chr12:105501055 KIAA1033 0.71 5.98 0.34 7.09e-9 IgG glycosylation; CESC cis rs9834373 0.811 rs9837213 chr3:78481884 A/G cg06138941 chr3:78371609 NA -0.42 -5.15 -0.3 5.18e-7 Protein quantitative trait loci; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19189310 chr6:34393779 RPS10 -0.48 -6.5 -0.37 4.07e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs796364 0.806 rs74771155 chr2:200913743 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg19077165 chr18:44547161 KATNAL2 -0.51 -7.09 -0.4 1.21e-11 Personality dimensions; CESC cis rs1008375 0.872 rs2315552 chr4:17627294 A/G cg15017067 chr4:17643749 FAM184B 0.39 5.53 0.32 7.68e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8060686 0.545 rs12596883 chr16:68172416 A/T cg26727032 chr16:67993705 SLC12A4 -0.5 -5.45 -0.32 1.16e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs854765 0.583 rs4257260 chr17:17857003 A/G cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg02807482 chr3:125708958 NA -0.39 -5.07 -0.3 7.59e-7 Blood pressure (smoking interaction); CESC cis rs4654899 0.865 rs6700459 chr1:21279396 T/C cg05370193 chr1:21551575 ECE1 0.41 6.2 0.36 2.21e-9 Superior frontal gyrus grey matter volume; CESC cis rs12545109 0.800 rs1837614 chr8:57414497 T/A cg09654669 chr8:57350985 NA -0.46 -6.25 -0.36 1.67e-9 Obesity-related traits; CESC cis rs17376456 0.542 rs35672980 chr5:93284877 A/T cg25358565 chr5:93447407 FAM172A -0.45 -5.29 -0.31 2.62e-7 Diabetic retinopathy; CESC cis rs7789940 1.000 rs2072435 chr7:75959188 G/A cg10167463 chr7:75959203 YWHAG -0.56 -7.09 -0.4 1.23e-11 Multiple sclerosis; CESC cis rs637571 0.522 rs679581 chr11:65746653 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.76 11.08 0.56 1.05e-23 Eosinophil percentage of white cells; CESC cis rs317689 0.718 rs645026 chr12:69757931 G/A cg20891283 chr12:69753455 YEATS4 0.63 7.35 0.41 2.45e-12 Response to diuretic therapy; CESC cis rs10463316 0.894 rs7703283 chr5:150764904 C/T cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14080940 chr6:79944542 HMGN3 -0.43 -6.7 -0.38 1.21e-10 Gambling; CESC cis rs2066819 1.000 rs74673257 chr12:56638077 T/C cg26734620 chr12:56694298 CS 1.04 6.73 0.38 1.06e-10 Psoriasis vulgaris; CESC cis rs2243480 1.000 rs1039664 chr7:65449716 T/G cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs10088262 0.629 rs12541177 chr8:124800273 G/T cg15047889 chr8:124780837 FAM91A1 -0.52 -6.58 -0.37 2.57e-10 Pancreatic cancer; CESC cis rs8072100 0.840 rs4968319 chr17:45464967 A/G cg08085267 chr17:45401833 C17orf57 -0.52 -6.92 -0.39 3.47e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs13242816 1.000 rs6979182 chr7:116119345 T/G cg04696780 chr7:116139425 CAV2 -0.59 -5.23 -0.31 3.42e-7 P wave duration; CESC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg06481639 chr22:41940642 POLR3H -0.62 -6.57 -0.37 2.66e-10 Vitiligo; CESC trans rs1545843 0.564 rs2611292 chr12:84891790 C/T cg03015433 chr16:56623111 MT3 0.33 6.1 0.35 3.76e-9 Major depressive disorder; CESC cis rs889398 0.802 rs12925700 chr16:69793463 C/A cg09409435 chr16:70099608 PDXDC2 -0.42 -5.2 -0.3 3.96e-7 Body mass index; CESC cis rs4654899 0.758 rs6668370 chr1:21369568 C/T cg05370193 chr1:21551575 ECE1 0.35 5.28 0.31 2.63e-7 Superior frontal gyrus grey matter volume; CESC cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg15541040 chr2:3486749 NA -0.43 -5.38 -0.31 1.64e-7 Neurofibrillary tangles; CESC cis rs7267979 0.586 rs6050439 chr20:25192331 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.67 11.21 0.57 4.12e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg11890956 chr21:40555474 PSMG1 1.16 21.11 0.79 1.03e-58 Cognitive function; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg21871735 chr16:2015157 SNHG9;RPS2;SNORA78 0.48 6.3 0.36 1.27e-9 Obesity-related traits; CESC cis rs78456975 1.000 rs6708604 chr2:1556887 C/T cg26248373 chr2:1572462 NA -0.58 -5.22 -0.31 3.67e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs3820068 0.580 rs34426856 chr1:16006315 C/T cg17385448 chr1:15911702 AGMAT 0.4 6.26 0.36 1.55e-9 Systolic blood pressure; CESC cis rs3733585 0.699 rs6844787 chr4:9959233 A/G cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg07507251 chr3:52567010 NT5DC2 0.4 7.07 0.4 1.34e-11 Bipolar disorder; CESC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg21770322 chr7:97807741 LMTK2 0.58 8.75 0.47 2.54e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs2228479 0.850 rs11648433 chr16:89965055 G/A cg00800038 chr16:89945340 TCF25 -0.91 -7.41 -0.41 1.71e-12 Skin colour saturation; CESC cis rs8077577 0.747 rs3829956 chr17:18219835 A/G cg16794390 chr17:18148240 FLII 0.4 6.34 0.36 9.74e-10 Obesity-related traits; CESC trans rs2727020 0.681 rs2866362 chr11:49379316 A/G cg03929089 chr4:120376271 NA -0.79 -11.94 -0.59 1.39e-26 Coronary artery disease; CESC cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg00701064 chr4:6280414 WFS1 0.7 12.17 0.6 2.37e-27 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg08888203 chr3:10149979 C3orf24 0.48 6.06 0.35 4.71e-9 Alzheimer's disease; CESC cis rs75804782 0.521 rs60779166 chr2:239433943 G/A cg18131467 chr2:239335373 ASB1 -0.67 -5.1 -0.3 6.5e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs7799006 0.606 rs12669625 chr7:2315950 C/T cg12745145 chr7:2261452 MAD1L1 -0.32 -5.06 -0.3 8.03e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.47 -0.32 1.06e-7 Aortic root size; CESC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg10862848 chr6:42927986 GNMT -0.26 -6.54 -0.37 3.18e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7662987 0.517 rs1154410 chr4:100006645 A/G cg12011299 chr4:100065546 ADH4 0.58 6.6 0.38 2.23e-10 Smoking initiation; CESC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC trans rs116095464 0.681 rs9687745 chr5:229309 C/T cg00938859 chr5:1591904 SDHAP3 0.62 6.79 0.38 7.53e-11 Breast cancer; CESC cis rs11122272 0.668 rs1122131 chr1:231476501 A/G cg06096015 chr1:231504339 EGLN1 0.44 6.47 0.37 4.74e-10 Hemoglobin concentration; CESC cis rs4974559 0.790 rs6850727 chr4:1323273 G/C cg02980000 chr4:1222292 CTBP1 0.67 7.63 0.42 4.21e-13 Systolic blood pressure; CESC cis rs2439831 0.681 rs2278859 chr15:43632960 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.79 0.55 9.67e-23 Lung cancer in ever smokers; CESC cis rs1008375 1.000 rs28545485 chr4:17645376 C/T cg16339924 chr4:17578868 LAP3 0.56 7.02 0.4 1.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs931812 1.000 rs4734494 chr8:101917721 T/C cg20993868 chr7:22813445 NA 0.44 6.31 0.36 1.18e-9 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs796364 0.806 rs11679658 chr2:200923081 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.86 -7.81 -0.43 1.3e-13 Schizophrenia; CESC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Depression; CESC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Depression; CESC cis rs7605827 0.930 rs7602186 chr2:15510003 C/T cg19274914 chr2:15703543 NA 0.33 5.96 0.34 7.81e-9 Educational attainment (years of education); CESC cis rs10242455 0.702 rs45448997 chr7:99041598 G/C cg18809830 chr7:99032528 PTCD1 -0.63 -5.13 -0.3 5.68e-7 Blood metabolite levels; CESC cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg18527119 chr7:66119851 NA 0.52 5.58 0.32 5.98e-8 Aortic root size; CESC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg13393036 chr8:95962371 TP53INP1 -0.49 -10.52 -0.54 7.38e-22 Type 2 diabetes; CESC cis rs7107174 0.892 rs2510033 chr11:77941771 T/G cg02023728 chr11:77925099 USP35 0.48 6.3 0.36 1.24e-9 Testicular germ cell tumor; CESC cis rs67072384 0.818 rs2291290 chr11:72465877 T/C cg04827223 chr11:72435913 ARAP1 -0.7 -7.1 -0.4 1.16e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs763121 0.853 rs138712 chr22:39141600 C/T cg21395723 chr22:39101663 GTPBP1 0.46 5.97 0.34 7.43e-9 Menopause (age at onset); CESC cis rs741677 0.586 rs58180134 chr17:499297 C/A cg15660573 chr17:549704 VPS53 -0.58 -7.27 -0.41 4.13e-12 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); CESC cis rs9815354 0.638 rs76276404 chr3:41931770 A/G cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg02269571 chr22:50332266 NA -0.56 -6.99 -0.39 2.26e-11 Schizophrenia; CESC cis rs4555082 1.000 rs4334224 chr14:105759198 C/T cg13114125 chr14:105738426 BRF1 -0.74 -9.45 -0.5 1.92e-18 Mean platelet volume;Platelet distribution width; CESC cis rs7914558 1.000 rs7899084 chr10:104872547 A/T cg04362960 chr10:104952993 NT5C2 0.46 5.92 0.34 9.98e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6665290 0.901 rs61834005 chr1:227202789 C/T cg10327440 chr1:227177885 CDC42BPA -1.16 -25.99 -0.85 7.59e-75 Myeloid white cell count; CESC cis rs78456975 1.000 rs6712176 chr2:1556393 C/T cg26248373 chr2:1572462 NA -0.59 -5.69 -0.33 3.31e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4631830 0.900 rs10763546 chr10:51536399 C/G cg16070123 chr10:51489643 NA -0.35 -5.25 -0.31 3.12e-7 Prostate-specific antigen levels; CESC cis rs7590720 0.851 rs13006614 chr2:216876204 C/T cg12620499 chr2:216877984 MREG 0.84 12.23 0.6 1.46e-27 Alcohol dependence; CESC cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg19539972 chr4:7069911 GRPEL1 0.79 9.97 0.52 4.37e-20 Monocyte percentage of white cells; CESC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg12963246 chr6:28129442 ZNF389 0.57 7.78 0.43 1.65e-13 Depression; CESC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.76 -0.33 2.33e-8 Total body bone mineral density; CESC cis rs738322 0.935 rs75387 chr22:38572057 C/T cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC cis rs6968419 0.788 rs67915501 chr7:115822036 C/T cg02561103 chr7:115862891 TES -0.39 -5.24 -0.31 3.34e-7 Intraocular pressure; CESC cis rs11608355 0.521 rs7967632 chr12:109848000 C/G cg19025524 chr12:109796872 NA -0.53 -7.24 -0.41 4.76e-12 Neuroticism; CESC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.41e-28 Prudent dietary pattern; CESC cis rs9325144 0.534 rs1843866 chr12:38703160 G/T cg26384229 chr12:38710491 ALG10B 0.59 8.79 0.48 1.96e-16 Morning vs. evening chronotype; CESC cis rs6842047 0.809 rs3087505 chr4:187179486 A/G cg02012338 chr4:187126139 CYP4V2 0.62 5.06 0.3 8e-7 Blood protein levels; CESC cis rs6540556 0.769 rs17389198 chr1:209922058 G/A cg05527609 chr1:210001259 C1orf107 -0.66 -7.62 -0.42 4.65e-13 Red blood cell count; CESC cis rs6032067 0.929 rs17424474 chr20:43804797 C/A cg10761708 chr20:43804764 PI3 0.53 6.33 0.36 1.04e-9 Blood protein levels; CESC cis rs910316 0.967 rs1071989 chr14:75564659 G/T cg11812906 chr14:75593930 NEK9 0.89 15.08 0.68 1.6e-37 Height; CESC cis rs10861342 1.000 rs10861358 chr12:105559563 G/A cg23923672 chr12:105501055 KIAA1033 0.68 5.48 0.32 9.87e-8 IgG glycosylation; CESC cis rs10883723 0.669 rs2001595 chr10:104395085 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.58 6.96 0.39 2.65e-11 Allergic disease (asthma, hay fever or eczema); CESC trans rs9467711 0.606 rs34878490 chr6:26370572 C/T cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC cis rs6662572 1.000 rs6662999 chr1:46119351 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.53 5.57 0.32 6.17e-8 Blood protein levels; CESC cis rs2070433 0.706 rs3788265 chr21:47833789 G/T cg12379764 chr21:47803548 PCNT 0.62 6.42 0.37 6.28e-10 Lymphocyte counts; CESC cis rs4268898 0.610 rs34216622 chr2:24463445 G/C cg20701182 chr2:24300061 SF3B14 0.63 6.89 0.39 4.11e-11 Asthma; CESC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg04267008 chr7:1944627 MAD1L1 -0.6 -7.33 -0.41 2.73e-12 Bipolar disorder and schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13786513 chr19:45648562 NA 0.52 7.14 0.4 8.81e-12 Fibrinogen levels; CESC cis rs9362426 0.708 rs6907825 chr6:88102822 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.52 6.14 0.35 2.93e-9 Depressive episodes in bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07645393 chr12:112123605 ACAD10;BRAP 0.56 6.02 0.35 5.65e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17397401 chr15:75230745 COX5A -0.56 -6.61 -0.38 2.13e-10 Gut microbiome composition (summer); CESC cis rs6121246 0.559 rs6060919 chr20:30331922 A/T cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs9815354 0.680 rs73073274 chr3:42022810 T/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs6598955 0.724 rs4659420 chr1:26614333 G/A cg04990556 chr1:26633338 UBXN11 -0.8 -11.56 -0.58 2.7e-25 Obesity-related traits; CESC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg09177884 chr7:1199841 ZFAND2A -0.5 -6.23 -0.36 1.83e-9 Longevity;Endometriosis; CESC cis rs1153858 0.943 rs8038342 chr15:45651537 T/C cg21132104 chr15:45694354 SPATA5L1 0.85 11.64 0.58 1.47e-25 Homoarginine levels; CESC cis rs4911259 0.552 rs62208880 chr20:31463284 T/C cg13636640 chr20:31349939 DNMT3B -0.53 -7.33 -0.41 2.78e-12 Inflammatory bowel disease; CESC cis rs6736093 0.733 rs34974772 chr2:112810011 T/C cg12686935 chr2:112915763 FBLN7 -0.43 -5.65 -0.33 4.2e-8 Coronary artery disease; CESC cis rs9303401 0.538 rs35454383 chr17:56475599 C/T cg25039879 chr17:56429692 SUPT4H1 0.61 5.93 0.34 9.22e-9 Cognitive test performance; CESC cis rs5753618 0.583 rs8141150 chr22:31800336 C/T cg00478049 chr22:31556069 RNF185 -0.42 -5.03 -0.3 8.97e-7 Colorectal cancer; CESC cis rs17826219 0.706 rs61643715 chr17:29057762 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Body mass index; CESC cis rs4555082 1.000 rs4555082 chr14:105758964 C/T cg06808227 chr14:105710500 BRF1 -0.52 -6.31 -0.36 1.16e-9 Mean platelet volume;Platelet distribution width; CESC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg11644478 chr21:40555479 PSMG1 1.01 16.0 0.7 8.5e-41 Cognitive function; CESC cis rs7772486 0.686 rs9390349 chr6:146054430 T/G cg05347473 chr6:146136440 FBXO30 -0.51 -6.75 -0.38 9.36e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1348850 0.914 rs4893961 chr2:178411075 A/G cg22681709 chr2:178499509 PDE11A -0.39 -5.8 -0.34 1.91e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs12310956 0.532 rs1352211 chr12:33983132 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.64 0.38 1.82e-10 Morning vs. evening chronotype; CESC cis rs9611565 0.649 rs5758434 chr22:42116163 G/A cg06634786 chr22:41940651 POLR3H 0.45 5.07 0.3 7.43e-7 Vitiligo; CESC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg18904891 chr8:8559673 CLDN23 0.72 8.03 0.44 3.21e-14 Obesity-related traits; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14435640 chr8:41436176 AGPAT6 -0.46 -6.07 -0.35 4.4e-9 Asthma; CESC cis rs7666738 0.546 rs1813970 chr4:98887167 A/G cg05340658 chr4:99064831 C4orf37 -0.56 -6.92 -0.39 3.48e-11 Colonoscopy-negative controls vs population controls; CESC cis rs5753618 0.561 rs4820963 chr22:31698166 C/T cg13145458 chr22:31556086 RNF185 0.52 5.81 0.34 1.81e-8 Colorectal cancer; CESC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.75e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9916302 0.904 rs35285898 chr17:37555872 A/C cg20243544 chr17:37824526 PNMT -0.51 -6.5 -0.37 4.03e-10 Glomerular filtration rate (creatinine); CESC cis rs9389248 0.500 rs116273677 chr6:135339135 A/C cg22676075 chr6:135203613 NA 0.52 7.42 0.41 1.64e-12 High light scatter reticulocyte percentage of red cells; CESC trans rs11039798 0.841 rs10839174 chr11:48931185 G/A cg15704280 chr7:45808275 SEPT13 0.7 6.56 0.37 2.74e-10 Axial length; CESC cis rs13315871 0.722 rs3952239 chr3:58312057 G/T cg20936604 chr3:58311152 NA -0.52 -5.31 -0.31 2.3e-7 Cholesterol, total; CESC cis rs34779708 0.966 rs4934732 chr10:35431684 T/C cg04310649 chr10:35416472 CREM -0.53 -6.62 -0.38 2.02e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs763014 0.931 rs7192508 chr16:630367 C/T cg00802000 chr16:706648 WDR90 -0.42 -6.36 -0.36 8.74e-10 Height; CESC cis rs2721195 0.874 rs2721173 chr8:145744429 C/T cg17328964 chr8:145687451 CYHR1 -0.42 -5.89 -0.34 1.17e-8 Age at first birth; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17424859 chr6:71319002 NA 0.47 6.14 0.35 3.01e-9 Ulcerative colitis; CESC cis rs2777491 0.957 rs7181911 chr15:41674060 T/C cg20272979 chr15:41787780 ITPKA 0.36 5.11 0.3 6.11e-7 Ulcerative colitis; CESC cis rs7666738 0.830 rs13121766 chr4:98935766 A/C cg03467027 chr4:99064603 C4orf37 0.45 5.62 0.33 4.92e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg27266027 chr21:40555129 PSMG1 0.45 5.33 0.31 2.07e-7 Cognitive function; CESC cis rs4699052 0.963 rs6849319 chr4:104192742 G/C cg16532752 chr4:104119610 CENPE -0.43 -5.96 -0.34 8.21e-9 Testicular germ cell tumor; CESC cis rs769267 0.792 rs4808961 chr19:19577215 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.23 0.41 5.22e-12 Tonsillectomy; CESC cis rs7116495 0.609 rs10898812 chr11:71698801 G/A cg18441811 chr11:71824068 C11orf51 -0.82 -5.33 -0.31 2.05e-7 Severe influenza A (H1N1) infection; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23246789 chr2:179316083 PRKRA;DFNB59;MIR548N -0.52 -6.1 -0.35 3.66e-9 Ulcerative colitis; CESC cis rs1153858 1.000 rs1145091 chr15:45649996 A/G cg10760299 chr15:45669010 GATM 0.37 5.17 0.3 4.63e-7 Homoarginine levels; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg09737314 chr17:6899359 ALOX12 0.46 8.04 0.44 3.09e-14 Tonsillectomy; CESC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg04013166 chr16:89971882 TCF25 0.77 6.55 0.37 3.05e-10 Skin colour saturation; CESC cis rs7044106 0.762 rs12003646 chr9:123470621 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.99 0.56 2.09e-23 Hip circumference adjusted for BMI; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00019576 chr8:144337537 ZFP41 -0.46 -6.32 -0.36 1.1e-9 Systemic lupus erythematosus; CESC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg13866156 chr1:1669148 SLC35E2 0.53 7.2 0.4 6.16e-12 Body mass index; CESC cis rs11098499 0.691 rs9996644 chr4:120238877 G/T cg09307838 chr4:120376055 NA 0.78 10.46 0.54 1.15e-21 Corneal astigmatism; CESC cis rs2573652 0.722 rs12595247 chr15:100541689 C/T cg00587665 chr15:100533223 ADAMTS17 -0.43 -6.94 -0.39 3.07e-11 Height; CESC cis rs1707322 0.752 rs61784798 chr1:46173481 C/T cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27539627 chr3:122513065 DIRC2;HSPBAP1 0.5 6.37 0.36 8.51e-10 Gut microbiota (bacterial taxa); CESC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg11494091 chr17:61959527 GH2 0.73 12.66 0.61 4.86e-29 Prudent dietary pattern; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg07318050 chr1:233086124 C1orf57 -0.42 -6.73 -0.38 1.06e-10 Vertical cup-disc ratio; CESC cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg12826209 chr6:26865740 GUSBL1 0.75 8.79 0.48 1.88e-16 Intelligence (multi-trait analysis); CESC cis rs9467711 0.606 rs2073527 chr6:26374978 T/C cg14345882 chr6:26364793 BTN3A2 0.63 6.39 0.37 7.52e-10 Autism spectrum disorder or schizophrenia; CESC cis rs6484504 0.532 rs2774403 chr11:31320530 A/T cg14844989 chr11:31128820 NA 0.37 5.34 0.31 2.01e-7 Red blood cell count; CESC cis rs12545109 0.800 rs1553969 chr8:57420187 A/G cg09654669 chr8:57350985 NA -0.45 -6.27 -0.36 1.47e-9 Obesity-related traits; CESC cis rs9488822 0.636 rs7745074 chr6:116347432 G/A cg05304507 chr6:116381966 FRK 0.25 6.58 0.37 2.49e-10 Cholesterol, total;LDL cholesterol; CESC cis rs11785400 0.793 rs4430071 chr8:143737680 T/C cg10596483 chr8:143751796 JRK 0.43 5.41 0.32 1.37e-7 Schizophrenia; CESC cis rs79387448 1.000 rs79387448 chr2:103215410 C/T cg09003973 chr2:102972529 NA 0.65 5.14 0.3 5.33e-7 Gut microbiota (bacterial taxa); CESC cis rs2408955 0.504 rs11168441 chr12:48576054 G/A cg04545296 chr12:48745243 ZNF641 0.35 5.9 0.34 1.09e-8 Glycated hemoglobin levels; CESC cis rs4253772 0.637 rs9627402 chr22:46702586 C/T cg00784671 chr22:46762841 CELSR1 -0.5 -5.56 -0.32 6.44e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7508 0.694 rs2073573 chr8:17921673 G/T cg18067069 chr8:17937731 ASAH1 -0.39 -5.19 -0.3 4.21e-7 Atrial fibrillation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19760249 chr17:79254595 SLC38A10 0.46 6.74 0.38 9.63e-11 Fibrinogen levels; CESC cis rs3026101 0.578 rs1806238 chr17:5295502 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs10197940 0.662 rs10175134 chr2:152299355 G/A cg19508488 chr2:152266495 RIF1 0.51 5.62 0.33 4.95e-8 Lung cancer; CESC cis rs10129255 0.500 rs2105989 chr14:107138216 C/T cg23076370 chr14:107095027 NA -0.65 -9.65 -0.51 4.39e-19 Kawasaki disease; CESC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg08470875 chr2:26401718 FAM59B -0.62 -6.71 -0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs9287719 0.967 rs2287061 chr2:10743153 C/T cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs9325144 0.600 rs6582634 chr12:38748041 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.68 0.43 3.07e-13 Morning vs. evening chronotype; CESC cis rs2797160 1.000 rs1832979 chr6:125997436 A/G cg05901451 chr6:126070800 HEY2 -0.45 -6.69 -0.38 1.3100000000000001e-10 Endometrial cancer; CESC cis rs7091068 0.518 rs1409337 chr10:95439822 T/C cg20715218 chr10:95462985 C10orf4 0.53 6.42 0.37 6.42e-10 Urinary tract infection frequency; CESC cis rs2243480 0.803 rs35480979 chr7:65357084 A/G cg18252515 chr7:66147081 NA -1.01 -9.73 -0.51 2.51e-19 Diabetic kidney disease; CESC cis rs4076764 0.846 rs4255362 chr1:163424630 G/A cg24596788 chr1:163392923 NA -0.41 -5.81 -0.34 1.8e-8 Motion sickness; CESC trans rs629535 0.814 rs62513371 chr8:70077779 T/A cg21567404 chr3:27674614 NA -0.89 -10.61 -0.55 3.89e-22 Dupuytren's disease; CESC cis rs2816062 0.813 rs2745321 chr1:18889198 G/C cg18795169 chr1:18902165 NA -0.91 -17.87 -0.74 2.1e-47 Urate levels in lean individuals; CESC cis rs12586317 0.511 rs75552348 chr14:35385747 G/A cg05294307 chr14:35346193 BAZ1A -0.53 -5.24 -0.31 3.25e-7 Psoriasis; CESC cis rs7202877 0.610 rs4888381 chr16:75356847 C/A cg04384234 chr16:75411784 CFDP1 -0.48 -5.67 -0.33 3.64e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs7267979 0.966 rs6050532 chr20:25308793 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -18.7 -0.75 2.48e-50 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22153931 chr7:43917675 URGCP -0.56 -6.22 -0.36 1.93e-9 Gut microbiome composition (summer); CESC cis rs9388451 0.868 rs1268083 chr6:126049040 T/C cg05901451 chr6:126070800 HEY2 0.62 9.2 0.49 1.12e-17 Brugada syndrome; CESC cis rs1153858 1.000 rs67744121 chr15:45677237 C/G cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg14393609 chr7:65229607 NA -0.52 -7.0 -0.4 2.1e-11 Corneal structure; CESC cis rs5769765 1.000 rs34774661 chr22:50267508 C/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs826838 1.000 rs10880785 chr12:38655405 T/G cg13010199 chr12:38710504 ALG10B 0.59 8.31 0.45 4.93e-15 Heart rate; CESC cis rs7385804 0.761 rs568733 chr7:100311662 G/T cg16850897 chr7:100343110 ZAN 0.46 6.26 0.36 1.56e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs1801251 0.778 rs709933 chr2:233733144 G/A cg25237894 chr2:233734115 C2orf82 -0.49 -8.48 -0.46 1.55e-15 Coronary artery disease; CESC cis rs10752881 1.000 rs10911191 chr1:182984524 A/G ch.1.3577855R chr1:183094577 LAMC1 0.82 12.96 0.62 4.48e-30 Colorectal cancer; CESC cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.03 0.52 2.72e-20 Hip circumference adjusted for BMI; CESC cis rs2050392 0.517 rs619864 chr10:30750950 A/G cg18806716 chr10:30721971 MAP3K8 0.48 7.34 0.41 2.68e-12 Inflammatory bowel disease; CESC cis rs72945132 0.825 rs12287883 chr11:70122369 C/T cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC trans rs9834373 0.573 rs9874385 chr3:78522298 C/T cg21593409 chr16:88706389 IL17C -0.42 -6.04 -0.35 5.2e-9 Protein quantitative trait loci; CESC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg17372223 chr3:52568218 NT5DC2 0.42 6.43 0.37 5.79e-10 Bipolar disorder; CESC cis rs3733585 0.673 rs4495037 chr4:9954050 C/G cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11098499 0.863 rs3822191 chr4:120428101 A/T cg09307838 chr4:120376055 NA 0.95 13.17 0.63 8.54e-31 Corneal astigmatism; CESC trans rs10510776 0.875 rs11710973 chr3:55217512 C/T cg27011042 chr15:89456239 MFGE8 0.6 6.24 0.36 1.77e-9 Cancer; CESC cis rs6060717 0.610 rs2794383 chr20:34615152 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.49 6.23 0.36 1.86e-9 Hip circumference adjusted for BMI; CESC cis rs6582630 0.519 rs7294300 chr12:38277359 C/A cg13010199 chr12:38710504 ALG10B 0.52 6.38 0.36 8.04e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs13064411 0.627 rs28536176 chr3:113143625 T/C cg18753928 chr3:113234510 CCDC52 -0.49 -5.5 -0.32 8.88e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs8072100 0.811 rs1912483 chr17:45443494 A/G cg08085267 chr17:45401833 C17orf57 -0.56 -7.4 -0.41 1.81e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg06001716 chr17:41278141 BRCA1;NBR2 -0.38 -5.11 -0.3 6.32e-7 Menopause (age at onset); CESC cis rs12497850 1.000 rs1352420 chr3:48757291 A/G cg06212747 chr3:49208901 KLHDC8B 0.63 8.36 0.46 3.47e-15 Parkinson's disease; CESC cis rs7829975 0.688 rs7827182 chr8:8380471 C/G cg15556689 chr8:8085844 FLJ10661 0.54 6.61 0.38 2.1e-10 Mood instability; CESC trans rs9858542 0.953 rs9827708 chr3:49649989 C/G cg21659725 chr3:3221576 CRBN -0.52 -6.47 -0.37 4.63e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6076065 0.963 rs6048777 chr20:23373302 C/T cg11657817 chr20:23433608 CST11 0.36 5.35 0.31 1.92e-7 Facial morphology (factor 15, philtrum width); CESC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.37 -0.5 3.42e-18 Alzheimer's disease; CESC cis rs11098499 0.754 rs12513083 chr4:120249612 A/T cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg18099408 chr3:52552593 STAB1 -0.36 -6.1 -0.35 3.79e-9 Electroencephalogram traits; CESC cis rs3857067 0.680 rs1509946 chr4:95109078 G/T cg11021082 chr4:95130006 SMARCAD1 -0.58 -8.62 -0.47 6.01e-16 QT interval; CESC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg00684032 chr4:1343700 KIAA1530 0.37 5.57 0.32 6.36e-8 Longevity; CESC cis rs7771547 0.573 rs629297 chr6:36398146 C/T cg07856975 chr6:36356162 ETV7 0.36 5.42 0.32 1.37e-7 Platelet distribution width; CESC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg25072359 chr17:41440525 NA 0.46 6.21 0.36 2.04e-9 Menopause (age at onset); CESC cis rs2235642 0.893 rs2076445 chr16:1592266 A/T cg10465839 chr16:1584050 IFT140;TMEM204 -0.32 -5.2 -0.3 3.91e-7 Coronary artery disease; CESC cis rs5769765 0.779 rs12170530 chr22:50318422 T/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.62 -6.38 -0.37 7.75e-10 Schizophrenia; CESC cis rs854765 0.647 rs854767 chr17:18018263 A/C cg09796270 chr17:17721594 SREBF1 -0.37 -5.03 -0.3 8.99e-7 Total body bone mineral density; CESC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.99 9.5 0.5 1.31e-18 Platelet count; CESC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs3820928 0.692 rs2396434 chr2:227775223 G/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.52 -0.42 8.7e-13 Pulmonary function; CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg07092213 chr7:1199455 ZFAND2A -0.42 -5.63 -0.33 4.63e-8 Longevity;Endometriosis; CESC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.31 -5.07 -0.3 7.35e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs8067354 0.645 rs1874548 chr17:57841357 A/G cg13753209 chr17:57696993 CLTC 0.56 6.1 0.35 3.83e-9 Hemoglobin concentration; CESC trans rs12310956 0.515 rs1405031 chr12:33958931 A/C cg26384229 chr12:38710491 ALG10B 0.48 6.68 0.38 1.36e-10 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16968475 chr7:2027283 MAD1L1 0.47 6.32 0.36 1.12e-9 Fibrinogen levels; CESC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.55 7.01 0.4 1.98e-11 Prudent dietary pattern; CESC cis rs11077998 1.000 rs11077998 chr17:80483946 C/G cg20173014 chr17:80541737 FOXK2 0.32 5.09 0.3 6.92e-7 Reticulocyte fraction of red cells; CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg18402987 chr7:1209562 NA 0.63 7.41 0.41 1.73e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20009499 chr17:57232567 SKA2;PRR11 -0.48 -6.23 -0.36 1.8e-9 Height; CESC cis rs2820292 0.670 rs6701026 chr1:201814004 C/T cg11586189 chr1:201857591 SHISA4 0.33 5.47 0.32 1.02e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs826838 1.000 rs7953227 chr12:38946193 G/A cg13010199 chr12:38710504 ALG10B 0.6 8.69 0.47 3.84e-16 Heart rate; CESC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs11997175 0.646 rs4733180 chr8:33700520 C/T ch.8.33884649F chr8:33765107 NA 0.56 7.43 0.42 1.52e-12 Body mass index; CESC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg17971929 chr21:40555470 PSMG1 1.05 16.42 0.71 2.82e-42 Cognitive function; CESC cis rs7103648 0.742 rs34937994 chr11:47389638 C/T cg20307385 chr11:47447363 PSMC3 0.9 13.35 0.63 1.96e-31 Diastolic blood pressure;Systolic blood pressure; CESC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg13126279 chr21:47581558 C21orf56 -0.48 -6.57 -0.37 2.6200000000000003e-10 Testicular germ cell tumor; CESC cis rs3087591 1.000 rs6505234 chr17:29688299 G/A cg24425628 chr17:29625626 OMG;NF1 -0.45 -5.61 -0.33 5.02e-8 Hip circumference; CESC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg17724175 chr1:150552817 MCL1 -0.39 -6.13 -0.35 3.12e-9 Melanoma; CESC cis rs35955747 0.902 rs7288735 chr22:31679546 G/A cg25791279 chr22:32026902 PISD -0.5 -6.01 -0.35 6.19e-9 Neutrophil count;Sum basophil neutrophil counts; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02205746 chr16:2732724 KCTD5 -0.42 -6.06 -0.35 4.58e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg14159672 chr1:205819179 PM20D1 0.81 12.97 0.62 3.97e-30 Menarche (age at onset); CESC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg23172400 chr8:95962367 TP53INP1 -0.41 -8.39 -0.46 3.02e-15 Type 2 diabetes; CESC cis rs11958404 0.932 rs72818127 chr5:157452227 C/T cg05962755 chr5:157440814 NA 0.63 7.2 0.4 6.33e-12 IgG glycosylation; CESC cis rs7772486 0.846 rs2748496 chr6:146321829 T/A cg23711669 chr6:146136114 FBXO30 0.79 10.98 0.56 2.31e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg22029157 chr1:209979665 IRF6 0.77 8.9 0.48 9.08e-17 Cleft lip with or without cleft palate; CESC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg09658497 chr7:2847517 GNA12 -0.35 -5.09 -0.3 6.89e-7 Height; CESC cis rs9902453 0.933 rs1128156 chr17:28513176 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.84 0.43 1.12e-13 Coffee consumption (cups per day); CESC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg16606324 chr3:10149918 C3orf24 0.43 5.11 0.3 6.19e-7 Alzheimer's disease; CESC cis rs909674 0.690 rs1972280 chr22:39831986 T/A cg24399712 chr22:39784796 NA -0.8 -11.01 -0.56 1.84e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.73 0.38 1.07e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs72781680 1.000 rs72781679 chr2:24237712 G/A cg20701182 chr2:24300061 SF3B14 0.82 6.96 0.39 2.66e-11 Lymphocyte counts; CESC cis rs6752107 0.967 rs10210302 chr2:234158839 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.45 6.46 0.37 5.04e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg23281280 chr6:28129359 ZNF389 0.5 6.56 0.37 2.75e-10 Parkinson's disease; CESC cis rs1348850 0.632 rs13008857 chr2:178514468 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.68 0.43 3.1e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.72 -0.33 2.89e-8 Menopause (age at onset); CESC cis rs3733585 0.673 rs4312757 chr4:9956145 T/A cg02734326 chr4:10020555 SLC2A9 -0.41 -5.87 -0.34 1.32e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs67311347 1.000 rs28871903 chr3:40511094 T/G cg24209194 chr3:40518798 ZNF619 0.5 6.09 0.35 4.06e-9 Renal cell carcinoma; CESC cis rs4891159 0.790 rs8087557 chr18:74116848 G/C cg24786174 chr18:74118243 ZNF516 -0.78 -12.64 -0.61 5.42e-29 Longevity; CESC cis rs1559088 1.000 rs1559087 chr19:33551041 A/G cg27124370 chr19:33622961 WDR88 0.41 5.1 0.3 6.57e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9318086 0.712 rs1886970 chr13:24440498 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.42 5.71 0.33 3.03e-8 Myopia (pathological); CESC cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg26597838 chr10:835615 NA 0.87 9.02 0.48 3.81e-17 Eosinophil percentage of granulocytes; CESC cis rs12101261 0.560 rs1035144 chr14:81445121 C/T cg06600135 chr14:81408086 NA 0.38 5.07 0.3 7.42e-7 Graves' disease; CESC cis rs7188697 0.922 rs28479997 chr16:58614877 G/A cg02549819 chr16:58548995 SETD6 0.44 5.43 0.32 1.26e-7 QT interval; CESC cis rs1538970 0.781 rs11211139 chr1:46015751 G/T cg05343316 chr1:45956843 TESK2 0.91 11.61 0.58 1.88e-25 Platelet count; CESC cis rs7809950 1.000 rs2712214 chr7:107188031 G/A cg23024343 chr7:107201750 COG5 -0.42 -5.87 -0.34 1.33e-8 Coronary artery disease; CESC cis rs9834373 0.853 rs13322524 chr3:78495720 A/G cg06138941 chr3:78371609 NA -0.43 -5.48 -0.32 9.88e-8 Protein quantitative trait loci; CESC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg03806693 chr22:41940476 POLR3H -1.17 -13.7 -0.64 1.12e-32 Vitiligo; CESC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg15921436 chr17:44337874 NA -0.43 -5.31 -0.31 2.32e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9302635 0.550 rs35959677 chr16:72200801 G/T cg16558253 chr16:72132732 DHX38 -0.41 -5.05 -0.3 8.41e-7 Blood protein levels; CESC cis rs4243830 0.850 rs12046229 chr1:6580397 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.69 5.11 0.3 6.23e-7 Body mass index; CESC cis rs12474201 0.588 rs3768719 chr2:46987935 T/G cg06386533 chr2:46925753 SOCS5 0.55 7.46 0.42 1.21e-12 Height; CESC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs10754283 0.967 rs7552896 chr1:90103194 A/G cg21401794 chr1:90099060 LRRC8C 0.69 9.31 0.5 4.95e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs72945132 0.882 rs59398290 chr11:70134819 G/A cg00319359 chr11:70116639 PPFIA1 0.78 7.67 0.43 3.32e-13 Coronary artery disease; CESC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg16405210 chr4:1374714 KIAA1530 0.47 5.97 0.34 7.48e-9 Obesity-related traits; CESC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg08470875 chr2:26401718 FAM59B 0.7 6.92 0.39 3.47e-11 Gut microbiome composition (summer); CESC cis rs2066819 1.000 rs2643626 chr12:56726518 C/T cg26316697 chr12:56727976 PAN2 -0.7 -6.72 -0.38 1.08e-10 Psoriasis vulgaris; CESC cis rs1843834 0.539 rs1494109 chr2:225441833 G/A cg12698349 chr2:225449008 CUL3 0.62 8.74 0.47 2.73e-16 IgE levels in asthmatics (D.p. specific); CESC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25183890 chr8:94929275 PDP1 0.57 6.31 0.36 1.16e-9 Gut microbiome composition (summer); CESC cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 10.86 0.55 5.79e-23 Hip circumference adjusted for BMI; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09247696 chr2:74756297 HTRA2;AUP1 0.46 6.48 0.37 4.38e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12597458 0.763 rs3213422 chr16:72042682 A/C cg01557791 chr16:72042693 DHODH 0.85 12.82 0.62 1.36e-29 Prostate cancer; CESC cis rs9300255 0.602 rs2851450 chr12:123703501 C/T cg19016782 chr12:123741754 C12orf65 -0.45 -6.55 -0.37 2.97e-10 Neutrophil percentage of white cells; CESC cis rs3740713 1.000 rs76062966 chr11:18462404 C/A cg23797887 chr11:18477753 LDHAL6A -0.52 -5.2 -0.3 3.93e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7520050 0.931 rs11211189 chr1:46261584 A/T cg03146154 chr1:46216737 IPP -0.47 -6.09 -0.35 4.04e-9 Red blood cell count;Reticulocyte count; CESC cis rs863345 0.967 rs1418845 chr1:158479691 A/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.0 -0.35 6.55e-9 Pneumococcal bacteremia; CESC cis rs3733585 0.637 rs6850684 chr4:9964380 G/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.83 -0.59 3.28e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg06221963 chr1:154839813 KCNN3 -0.7 -12.09 -0.6 4.16e-27 Prostate cancer; CESC cis rs7149242 0.662 rs4905998 chr14:101181781 A/G cg18089426 chr14:101175970 NA -0.4 -6.66 -0.38 1.61e-10 Platelet count; CESC cis rs595982 0.702 rs626974 chr19:49375900 T/C cg03707168 chr19:49379127 PPP1R15A 0.32 5.14 0.3 5.38e-7 Red cell distribution width; CESC cis rs9309473 0.950 rs6546858 chr2:73838613 G/A cg20560298 chr2:73613845 ALMS1 -0.43 -5.74 -0.33 2.61e-8 Metabolite levels; CESC cis rs3733585 0.605 rs4697710 chr4:10122649 T/C cg00071950 chr4:10020882 SLC2A9 -0.65 -9.67 -0.51 3.96e-19 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg17372223 chr3:52568218 NT5DC2 0.43 6.43 0.37 5.85e-10 Bipolar disorder; CESC cis rs9443645 0.527 rs9361479 chr6:79723755 T/A cg05283184 chr6:79620031 NA -0.38 -5.51 -0.32 8.57e-8 Intelligence (multi-trait analysis); CESC cis rs11098499 0.754 rs34425882 chr4:120253177 G/A cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs400736 1.000 rs400736 chr1:8078309 T/C cg25007680 chr1:8021821 PARK7 0.72 10.41 0.54 1.66e-21 Response to antidepressants and depression; CESC cis rs9486719 1.000 rs34236778 chr6:96884556 C/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs3749237 0.595 rs3924462 chr3:49524236 T/G cg02487422 chr3:49467188 NICN1 0.56 8.19 0.45 1.09e-14 Resting heart rate; CESC cis rs12291225 0.679 rs11023178 chr11:14310282 G/A cg19336497 chr11:14380999 RRAS2 -0.37 -5.29 -0.31 2.58e-7 Sense of smell; CESC cis rs6060717 0.571 rs6060761 chr20:34612487 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -7.98 -0.44 4.46e-14 Hip circumference adjusted for BMI; CESC cis rs7223966 1.000 rs9903897 chr17:61716705 T/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.66 -0.33 3.84e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs35110281 0.748 rs162403 chr21:44963365 C/G cg21573476 chr21:45109991 RRP1B -0.44 -6.09 -0.35 4.02e-9 Mean corpuscular volume; CESC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.38 -6.14 -0.35 2.97e-9 Cystic fibrosis severity; CESC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg11764359 chr7:65958608 NA -0.79 -12.0 -0.59 9.01e-27 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21595175 chr5:180670701 SNORD95;GNB2L1 -0.48 -6.56 -0.37 2.83e-10 Fibrinogen levels; CESC trans rs1814175 0.645 rs847630 chr11:49926360 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs6963495 0.745 rs73192150 chr7:105211610 A/C cg02135003 chr7:105160482 PUS7 -0.48 -5.51 -0.32 8.52e-8 Bipolar disorder (body mass index interaction); CESC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -5.95 -0.34 8.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.21 -0.3 3.88e-7 Height; CESC cis rs5769765 0.862 rs138857 chr22:50199589 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.48 -5.2 -0.3 4.02e-7 Schizophrenia; CESC trans rs2657294 0.620 rs4746261 chr10:76845632 C/T cg20074007 chr10:99161109 RRP12 0.48 6.13 0.35 3.22e-9 Pneumonia; CESC cis rs9527 0.590 rs2281877 chr10:104866062 C/T cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs9322193 0.566 rs6912330 chr6:150229947 A/C cg01145232 chr6:150245071 RAET1G -0.53 -6.78 -0.38 7.71e-11 Lung cancer; CESC cis rs863345 0.504 rs857707 chr1:158564383 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -5.57 -0.32 6.31e-8 Pneumococcal bacteremia; CESC cis rs8114671 0.562 rs1013677 chr20:33468793 C/T cg24642439 chr20:33292090 TP53INP2 0.44 5.56 0.32 6.67e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17261830 chr14:75593525 NEK9 0.49 6.01 0.35 6.01e-9 Gut microbiome composition (summer); CESC cis rs3806843 0.778 rs2531346 chr5:140126139 T/G cg26395211 chr5:140044315 WDR55 0.39 5.13 0.3 5.55e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg00129232 chr17:37814104 STARD3 -0.56 -7.49 -0.42 1.05e-12 Glomerular filtration rate (creatinine); CESC cis rs10911232 0.507 rs10797829 chr1:183033228 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.86 -13.63 -0.64 2.03e-32 Hypertriglyceridemia; CESC cis rs561341 0.941 rs736678 chr17:30347423 G/T cg23018236 chr17:30244563 NA -0.55 -5.16 -0.3 4.77e-7 Hip circumference adjusted for BMI; CESC cis rs916888 0.773 rs199451 chr17:44801784 G/A cg01570182 chr17:44337453 NA 0.93 10.53 0.54 6.68e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9550616 0.801 rs9579788 chr13:20728013 T/C cg27436003 chr13:20734544 GJA3 0.36 5.15 0.3 5.04e-7 Facial emotion recognition (happy faces); CESC cis rs1062177 0.756 rs2964588 chr5:151118386 C/T cg12924095 chr5:151150029 G3BP1 -0.43 -5.29 -0.31 2.55e-7 Preschool internalizing problems; CESC cis rs113835537 0.529 rs11824771 chr11:66262550 T/C cg24851651 chr11:66362959 CCS 0.41 5.1 0.3 6.55e-7 Airway imaging phenotypes; CESC cis rs79057730 0.599 rs34411410 chr7:811721 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.87 7.34 0.41 2.59e-12 Initial pursuit acceleration; CESC cis rs7560272 0.669 rs7598660 chr2:73740425 C/T cg20560298 chr2:73613845 ALMS1 -0.37 -5.13 -0.3 5.74e-7 Schizophrenia; CESC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg12193833 chr17:30244370 NA -0.71 -7.29 -0.41 3.58e-12 Hip circumference adjusted for BMI; CESC trans rs1888221 0.510 rs7027148 chr9:117832663 A/C cg11017500 chr13:111290755 CARKD -0.46 -6.01 -0.35 5.99e-9 Glucose homeostasis traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08162257 chr15:90777190 CIB1;C15orf58 0.57 6.31 0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs7605827 0.893 rs7572131 chr2:15691886 G/A cg19274914 chr2:15703543 NA 0.36 6.39 0.37 7.29e-10 Educational attainment (years of education); CESC cis rs2204008 0.774 rs8186954 chr12:38318566 C/A cg26384229 chr12:38710491 ALG10B 0.66 9.82 0.52 1.26e-19 Bladder cancer; CESC cis rs7078219 0.505 rs10883362 chr10:101286984 C/T cg09788492 chr10:101292477 NKX2-3 0.33 6.31 0.36 1.14e-9 Dental caries; CESC cis rs2832191 0.716 rs7284006 chr21:30475186 T/A cg24692254 chr21:30365293 RNF160 0.99 17.24 0.73 3.61e-45 Dental caries; CESC cis rs4835473 0.699 rs4835127 chr4:144919125 C/A cg25736465 chr4:144833511 NA 0.42 6.28 0.36 1.38e-9 Immature fraction of reticulocytes; CESC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.46 6.39 0.37 7.27e-10 Menopause (age at onset); CESC cis rs2075671 0.855 rs62483567 chr7:100286435 G/A cg16850897 chr7:100343110 ZAN -0.7 -8.82 -0.48 1.62e-16 Other erythrocyte phenotypes; CESC cis rs2115630 0.875 rs8039472 chr15:85361644 A/G cg11189052 chr15:85197271 WDR73 -0.45 -5.86 -0.34 1.34e-8 P wave terminal force; CESC cis rs977987 0.966 rs62060551 chr16:75502312 A/C cg03315344 chr16:75512273 CHST6 0.53 7.74 0.43 2.16e-13 Dupuytren's disease; CESC cis rs2635047 0.593 rs7239323 chr18:44636506 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.42 -5.3 -0.31 2.46e-7 Educational attainment; CESC trans rs1728785 1.000 rs7192341 chr16:68569224 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.39 0.41 1.91e-12 Ulcerative colitis; CESC cis rs778371 0.723 rs283470 chr2:233656918 G/A cg08000102 chr2:233561755 GIGYF2 0.79 13.28 0.63 3.33e-31 Schizophrenia; CESC trans rs11764590 0.813 rs11768212 chr7:1992582 A/C cg11693508 chr17:37793320 STARD3 0.64 6.36 0.36 8.65e-10 Neuroticism; CESC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg08859206 chr1:53392774 SCP2 -0.59 -7.79 -0.43 1.5e-13 Monocyte count; CESC cis rs7085104 0.632 rs4290163 chr10:104610926 G/T cg04362960 chr10:104952993 NT5C2 0.45 5.85 0.34 1.48e-8 Immature fraction of reticulocytes;Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07617175 chr5:99871683 FAM174A -0.48 -6.56 -0.37 2.85e-10 Gut microbiota (bacterial taxa); CESC cis rs11690935 0.632 rs34242651 chr2:172553999 G/A cg13550731 chr2:172543902 DYNC1I2 0.6 8.37 0.46 3.42e-15 Schizophrenia; CESC cis rs7872515 0.838 rs6479403 chr9:94829156 A/G cg01248375 chr9:94877805 SPTLC1 0.52 5.74 0.33 2.53e-8 Bipolar disorder and schizophrenia; CESC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg03605463 chr16:89740564 NA 0.63 7.49 0.42 1.02e-12 Vitiligo; CESC cis rs6748734 0.625 rs7355583 chr2:241821707 T/C cg04034577 chr2:241836375 C2orf54 -0.29 -5.32 -0.31 2.23e-7 Urinary metabolites; CESC cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg12193833 chr17:30244370 NA -0.71 -6.53 -0.37 3.38e-10 Hip circumference adjusted for BMI; CESC cis rs4664293 1.000 rs6432540 chr2:160450703 G/A cg08347373 chr2:160653686 CD302 -0.32 -5.35 -0.31 1.93e-7 Monocyte percentage of white cells; CESC cis rs6598163 0.517 rs11246827 chr12:132296423 G/A cg10319629 chr12:132285459 NA 0.41 5.61 0.33 5.04e-8 Migraine; CESC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.6 -7.38 -0.41 2.04e-12 Height; CESC cis rs929354 0.713 rs6459733 chr7:156930550 G/C cg05182265 chr7:156933206 UBE3C -0.5 -7.27 -0.41 4.15e-12 Body mass index; CESC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 10.1 0.53 1.74e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg21770322 chr7:97807741 LMTK2 0.56 8.63 0.47 5.86e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs684232 0.623 rs391002 chr17:535441 T/G cg12384639 chr17:618140 VPS53 0.41 5.28 0.31 2.7e-7 Prostate cancer; CESC cis rs2235544 0.565 rs928441 chr1:54473368 C/A cg25741118 chr1:54482237 LDLRAD1 -0.25 -6.26 -0.36 1.55e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs17253792 0.822 rs112374071 chr14:56061919 C/T cg01858014 chr14:56050164 KTN1 -0.77 -5.28 -0.31 2.7e-7 Putamen volume; CESC cis rs858239 0.601 rs2068459 chr7:23154313 A/C cg23682824 chr7:23144976 KLHL7 0.49 6.49 0.37 4.19e-10 Cerebrospinal fluid biomarker levels; CESC cis rs561341 1.000 rs527256 chr17:30321293 C/G cg00745463 chr17:30367425 LRRC37B -0.82 -7.51 -0.42 9.09e-13 Hip circumference adjusted for BMI; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27331759 chr16:347891 AXIN1 0.45 6.26 0.36 1.54e-9 Fibrinogen levels; CESC cis rs1801251 1.000 rs67013068 chr2:233608253 G/C cg25237894 chr2:233734115 C2orf82 0.43 7.49 0.42 1e-12 Coronary artery disease; CESC cis rs637571 0.522 rs679581 chr11:65746653 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.46 6.09 0.35 3.91e-9 Eosinophil percentage of white cells; CESC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg01763666 chr17:80159506 CCDC57 -0.37 -5.14 -0.3 5.28e-7 Life satisfaction; CESC cis rs1461503 0.868 rs10790543 chr11:122838311 A/C cg27398637 chr11:122830231 C11orf63 -0.56 -8.42 -0.46 2.35e-15 Menarche (age at onset); CESC cis rs2282335 0.507 rs2498421 chr9:71855357 A/G cg14075627 chr9:71863002 TJP2 0.41 5.36 0.31 1.84e-7 Renal sinus fat; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03289548 chr10:114580989 NA 0.58 7.94 0.44 5.6e-14 Fibrinogen levels; CESC cis rs9640161 0.711 rs60268791 chr7:150023800 G/T cg10018233 chr7:150070692 REPIN1 0.45 7.41 0.41 1.72e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.72 0.43 2.43e-13 Prudent dietary pattern; CESC cis rs8077889 0.645 rs1230396 chr17:41843029 A/C cg26893861 chr17:41843967 DUSP3 -1.09 -22.71 -0.81 3.88e-64 Triglycerides; CESC cis rs6558174 0.965 rs4872524 chr8:22489537 A/G cg03733263 chr8:22462867 KIAA1967 0.44 5.91 0.34 1.06e-8 Breast cancer; CESC cis rs68170813 0.559 rs76933738 chr7:106814574 T/C cg02696742 chr7:106810147 HBP1 -0.55 -5.3 -0.31 2.44e-7 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14093526 chr11:134094620 VPS26B;NCAPD3 -0.46 -6.3 -0.36 1.26e-9 Ulcerative colitis; CESC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg12963246 chr6:28129442 ZNF389 0.5 6.4 0.37 6.93e-10 Parkinson's disease; CESC cis rs644799 0.544 rs525087 chr11:95632266 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.44 5.86 0.34 1.37e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04078658 chr7:2054064 MAD1L1 -0.49 -6.04 -0.35 5.14e-9 Gut microbiome composition (summer); CESC cis rs72627123 0.867 rs73303122 chr14:74486797 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.65 0.33 4.06e-8 Morning vs. evening chronotype; CESC cis rs7917772 0.502 rs10748827 chr10:104368336 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.7 0.43 2.66e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs11098499 0.754 rs2036860 chr4:120248934 A/G cg09307838 chr4:120376055 NA 0.78 10.55 0.54 5.92e-22 Corneal astigmatism; CESC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg20151795 chr6:28129481 ZNF389 0.46 5.97 0.34 7.59e-9 Depression; CESC cis rs72781680 1.000 rs72781649 chr2:24210864 A/G cg08917208 chr2:24149416 ATAD2B 0.92 8.28 0.45 6.31e-15 Lymphocyte counts; CESC cis rs9815354 1.000 rs1716668 chr3:41907850 T/C cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs35123781 0.955 rs34530707 chr5:139059016 G/A cg10513866 chr5:139070639 NA 0.4 5.92 0.34 1.02e-8 Schizophrenia; CESC cis rs4076764 1.000 rs7540279 chr1:163429970 A/T cg24596788 chr1:163392923 NA -0.47 -6.88 -0.39 4.37e-11 Motion sickness; CESC cis rs4006360 0.543 rs7502165 chr17:39268037 A/C cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.42 -5.3 -0.31 2.44e-7 Bipolar disorder and schizophrenia; CESC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg24675658 chr1:53192096 ZYG11B -0.6 -7.58 -0.42 5.81e-13 Monocyte count; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg26233408 chr17:78210670 SLC26A11 0.47 6.19 0.36 2.24e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6964587 1.000 rs2282970 chr7:91584281 A/G cg17063962 chr7:91808500 NA 0.57 7.72 0.43 2.46e-13 Breast cancer; CESC cis rs9457247 1.000 rs409356 chr6:167405226 T/A cg07741184 chr6:167504864 NA 0.28 5.1 0.3 6.54e-7 Crohn's disease; CESC trans rs208520 0.690 rs12192851 chr6:66705862 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.6 0.61 7.7e-29 Exhaled nitric oxide output; CESC cis rs1008375 0.932 rs11935124 chr4:17668200 G/A cg02297831 chr4:17616191 MED28 -0.47 -5.45 -0.32 1.15e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1126510 0.752 rs11666367 chr19:47120381 A/G cg07844738 chr19:47129343 PTGIR 0.32 5.06 0.3 7.99e-7 Ulcerative colitis; CESC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg25036284 chr2:26402008 FAM59B -0.59 -6.79 -0.39 7.13e-11 Gut microbiome composition (summer); CESC cis rs13191362 0.507 rs2849524 chr6:163127070 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.51 -5.97 -0.34 7.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7520050 0.902 rs9429088 chr1:46497500 T/A cg24296786 chr1:45957014 TESK2 0.41 5.21 0.3 3.75e-7 Red blood cell count;Reticulocyte count; CESC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.43 0.64 1e-31 Prudent dietary pattern; CESC cis rs7520050 0.933 rs11211203 chr1:46315592 A/G cg24296786 chr1:45957014 TESK2 0.43 5.42 0.32 1.32e-7 Red blood cell count;Reticulocyte count; CESC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg18190219 chr22:46762943 CELSR1 0.4 5.13 0.3 5.73e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7408868 0.706 rs7257550 chr19:15292088 C/G cg14696996 chr19:15285081 NOTCH3 0.98 10.56 0.54 5.55e-22 Pulse pressure; CESC cis rs12681366 0.734 rs2919672 chr8:95437147 G/A cg13257157 chr8:95487014 RAD54B 0.38 5.19 0.3 4.26e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.27 -0.31 2.89e-7 Aortic root size; CESC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.9 -13.65 -0.64 1.75e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs28374715 0.528 rs7178360 chr15:41631175 T/A cg02330683 chr15:41787940 ITPKA 0.48 5.65 0.33 4.05e-8 Ulcerative colitis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01307507 chr17:77751480 CBX2 -0.45 -6.01 -0.35 6.01e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611519 0.964 rs4820428 chr22:41537589 C/T cg03806693 chr22:41940476 POLR3H 0.6 6.26 0.36 1.56e-9 Neuroticism; CESC cis rs2425143 0.547 rs6141583 chr20:34572834 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.54 5.03 0.3 8.86e-7 Blood protein levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18909525 chr9:132403873 ASB6 0.49 6.2 0.36 2.11e-9 Gut microbiota (bacterial taxa); CESC cis rs7937682 0.575 rs10789851 chr11:111750955 G/C cg22437258 chr11:111473054 SIK2 -0.47 -5.24 -0.31 3.21e-7 Primary sclerosing cholangitis; CESC cis rs2404602 0.647 rs7178250 chr15:77099107 T/C cg23625390 chr15:77176239 SCAPER -0.47 -6.51 -0.37 3.72e-10 Blood metabolite levels; CESC cis rs1018836 0.884 rs13279263 chr8:91648780 T/C cg16814680 chr8:91681699 NA -0.7 -9.86 -0.52 9.97e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs8078723 1.000 rs3213762 chr17:38178627 A/G cg17467752 chr17:38218738 THRA 0.68 10.32 0.54 3.24e-21 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs4803468 1.000 rs284648 chr19:41926790 T/C cg09537434 chr19:41945824 ATP5SL -1.1 -20.32 -0.78 5.54e-56 Height; CESC cis rs7927592 0.956 rs11228269 chr11:68289796 A/G cg16797656 chr11:68205561 LRP5 0.38 5.23 0.31 3.44e-7 Total body bone mineral density; CESC trans rs66573146 0.656 rs111560662 chr4:6952766 C/T cg07817883 chr1:32538562 TMEM39B 1.29 8.52 0.46 1.25e-15 Granulocyte percentage of myeloid white cells; CESC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.79 8.0 0.44 3.92e-14 Platelet count; CESC trans rs2727020 0.553 rs61904166 chr11:49581461 T/C cg15704280 chr7:45808275 SEPT13 -0.94 -16.11 -0.7 3.47e-41 Coronary artery disease; CESC cis rs4654899 0.758 rs7530739 chr1:21447480 C/A cg05370193 chr1:21551575 ECE1 0.38 5.86 0.34 1.38e-8 Superior frontal gyrus grey matter volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04769705 chr14:69262517 C14orf181 -0.46 -6.1 -0.35 3.78e-9 Gut microbiota (bacterial taxa); CESC cis rs8092503 1.000 rs1819886 chr18:52493622 A/G cg12377874 chr18:52495404 RAB27B 0.34 5.75 0.33 2.49e-8 Childhood body mass index; CESC cis rs7149337 0.805 rs2999357 chr14:51606001 C/G cg23942311 chr14:51606299 NA 0.48 8.34 0.46 4.23e-15 Cancer; CESC cis rs757110 0.770 rs11024271 chr11:17395540 T/C cg15432903 chr11:17409602 KCNJ11 0.6 8.46 0.46 1.82e-15 Type 2 diabetes; CESC cis rs834811 0.797 rs2633365 chr7:135879797 A/G cg01726295 chr7:135938950 NA 0.37 6.18 0.36 2.36e-9 Post-traumatic stress disorder; CESC cis rs7584330 0.910 rs880930 chr2:238396872 G/C cg14458575 chr2:238380390 NA 0.69 10.02 0.52 3.03e-20 Prostate cancer; CESC trans rs931812 0.825 rs34235568 chr8:101895761 C/T cg20993868 chr7:22813445 NA 0.54 7.62 0.42 4.41e-13 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs9549367 0.789 rs8001506 chr13:113867153 A/C cg00898013 chr13:113819073 PROZ -0.51 -7.33 -0.41 2.72e-12 Platelet distribution width; CESC cis rs4481887 0.893 rs10888349 chr1:248448625 T/C cg00666640 chr1:248458726 OR2T12 0.39 6.69 0.38 1.29e-10 Common traits (Other); CESC cis rs1008375 0.966 rs6449329 chr4:17703677 T/C cg16339924 chr4:17578868 LAP3 0.62 7.68 0.43 3.01e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg24060327 chr5:131705240 SLC22A5 0.76 10.65 0.55 2.72e-22 Blood metabolite levels; CESC cis rs10791323 0.569 rs1119851 chr11:133742842 T/C cg15485101 chr11:133734466 NA 0.3 5.22 0.31 3.6e-7 Childhood ear infection; CESC cis rs11792861 0.926 rs3750451 chr9:111822866 C/T cg13535736 chr9:111863775 C9orf5 -0.52 -6.91 -0.39 3.69e-11 Menarche (age at onset); CESC cis rs12617721 0.756 rs3754889 chr2:99088633 T/G cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg01017244 chr2:74357527 NA 0.68 9.93 0.52 5.7e-20 Gestational age at birth (maternal effect); CESC cis rs6963495 0.818 rs55794529 chr7:105165747 T/C cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs12540874 0.759 rs12718572 chr7:50573325 C/T cg18232548 chr7:50535776 DDC -0.42 -5.61 -0.33 5.03e-8 Systemic sclerosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03533382 chr5:126853128 PRRC1 0.49 6.21 0.36 2.06e-9 Gut microbiota (bacterial taxa); CESC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 9.47 0.5 1.64e-18 Platelet count; CESC cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg05340658 chr4:99064831 C4orf37 0.84 12.83 0.62 1.22e-29 Colonoscopy-negative controls vs population controls; CESC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 13.04 0.63 2.35e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1707322 0.721 rs10890346 chr1:46223892 C/T cg03146154 chr1:46216737 IPP -0.8 -11.29 -0.57 2.13e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg26338869 chr17:61819248 STRADA 0.69 9.13 0.49 1.8e-17 Prudent dietary pattern; CESC cis rs2455799 0.613 rs2470536 chr3:15715156 G/C cg16303742 chr3:15540471 COLQ -0.38 -5.89 -0.34 1.17e-8 Mean platelet volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12360373 chr16:28834065 ATXN2L -0.42 -6.4 -0.37 7e-10 Gambling; CESC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg11644478 chr21:40555479 PSMG1 0.96 13.84 0.65 3.74e-33 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18855356 chr1:16957483 CROCCL1 -0.58 -6.56 -0.37 2.8e-10 Gut microbiome composition (summer); CESC cis rs12541635 0.934 rs57715289 chr8:106967124 A/T cg10147462 chr8:107024639 NA 0.41 5.57 0.32 6.41e-8 Age of smoking initiation; CESC cis rs2625529 0.713 rs12903980 chr15:72165549 C/T cg16672083 chr15:72433130 SENP8 -0.4 -5.2 -0.3 3.9e-7 Red blood cell count; CESC cis rs2279817 0.691 rs7543007 chr1:17990475 A/G cg21791023 chr1:18019539 ARHGEF10L -0.55 -7.23 -0.41 5.02e-12 Neuroticism; CESC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg19163074 chr7:65112434 INTS4L2 -0.46 -5.04 -0.3 8.45e-7 Aortic root size; CESC cis rs7917772 0.636 rs7894154 chr10:104524647 G/A cg04362960 chr10:104952993 NT5C2 0.45 5.11 0.3 6.07e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs9929218 0.581 rs4783676 chr16:68801077 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.87 14.08 0.65 5.39e-34 Colorectal cancer; CESC cis rs765787 0.530 rs4544188 chr15:45535393 C/A cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg18099408 chr3:52552593 STAB1 -0.32 -5.43 -0.32 1.28e-7 Intelligence (multi-trait analysis); CESC cis rs13242816 0.881 rs56034786 chr7:116106360 T/C cg04696780 chr7:116139425 CAV2 -0.62 -5.69 -0.33 3.31e-8 P wave duration; CESC cis rs71277158 0.688 rs73879178 chr3:169872834 C/T cg04067573 chr3:169899625 PHC3 0.71 7.16 0.4 7.88e-12 Prostate cancer; CESC cis rs796364 0.806 rs74938253 chr2:201008386 T/G cg23649088 chr2:200775458 C2orf69 -0.58 -5.71 -0.33 3.07e-8 Schizophrenia; CESC cis rs3782089 1.000 rs11602375 chr11:65296540 C/T cg21890820 chr11:65308645 LTBP3 1.14 8.54 0.46 1.05e-15 Height; CESC trans rs2733310 0.744 rs8040866 chr15:57162897 G/C cg13494055 chr3:59115467 NA -0.45 -6.17 -0.35 2.58e-9 Mean platelet volume; CESC cis rs9291683 0.546 rs13146686 chr4:10034933 A/G cg11266682 chr4:10021025 SLC2A9 0.62 11.63 0.58 1.54e-25 Bone mineral density; CESC cis rs11098499 0.909 rs78332141 chr4:120375782 C/T cg24375607 chr4:120327624 NA 0.46 5.66 0.33 3.94e-8 Corneal astigmatism; CESC cis rs911555 0.723 rs6575986 chr14:103886671 G/A cg24130564 chr14:104152367 KLC1 -0.52 -7.05 -0.4 1.56e-11 Intelligence (multi-trait analysis); CESC cis rs9811920 0.609 rs9817005 chr3:99682692 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.64 -10.1 -0.53 1.62e-20 Axial length; CESC cis rs6060717 0.536 rs6060676 chr20:34498551 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 5.44 0.32 1.22e-7 Hip circumference adjusted for BMI; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07423198 chr12:123458881 ABCB9;OGFOD2 -0.52 -6.7 -0.38 1.25e-10 Fibrinogen levels; CESC cis rs5763662 1.000 rs5763805 chr22:30538398 T/C cg21388335 chr22:29999516 NF2 -0.74 -5.03 -0.3 9.22e-7 LDL cholesterol levels;LDL cholesterol; CESC trans rs2670321 0.706 rs2200019 chr3:99095896 C/T cg03764381 chr16:10275410 GRIN2A -0.39 -6.05 -0.35 4.91e-9 RR interval (heart rate); CESC cis rs965469 0.846 rs7271575 chr20:3333877 C/T cg25506879 chr20:3388711 C20orf194 -0.54 -5.81 -0.34 1.82e-8 IFN-related cytopenia; CESC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg21770322 chr7:97807741 LMTK2 0.56 8.56 0.47 9.14e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs35110281 0.591 rs162369 chr21:44931965 G/A cg21573476 chr21:45109991 RRP1B -0.39 -5.51 -0.32 8.43e-8 Mean corpuscular volume; CESC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg18099408 chr3:52552593 STAB1 -0.32 -5.51 -0.32 8.6e-8 Electroencephalogram traits; CESC cis rs2404618 0.504 rs2906567 chr8:1494118 C/T cg02903104 chr8:1507517 DLGAP2 0.36 6.8 0.39 6.72e-11 Lung cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg08395899 chr10:12085052 UPF2 -0.46 -6.09 -0.35 3.91e-9 Asthma; CESC cis rs6964587 0.610 rs6942852 chr7:91437883 A/C cg17063962 chr7:91808500 NA 0.39 5.43 0.32 1.25e-7 Breast cancer; CESC cis rs9549260 0.564 rs9549270 chr13:41284193 G/T cg21288729 chr13:41239152 FOXO1 0.6 7.25 0.41 4.55e-12 Red blood cell count; CESC cis rs1008375 0.932 rs4698626 chr4:17605821 G/C cg16339924 chr4:17578868 LAP3 0.63 8.08 0.44 2.34e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4595586 0.545 rs11615584 chr12:39409350 C/G cg13010199 chr12:38710504 ALG10B 0.45 5.67 0.33 3.75e-8 Morning vs. evening chronotype; CESC cis rs4727027 0.933 rs6955564 chr7:148866173 A/G cg23158103 chr7:148848205 ZNF398 -0.36 -5.99 -0.35 6.97e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9815354 0.951 rs9831404 chr3:41871825 T/G cg03022575 chr3:42003672 ULK4 0.49 5.52 0.32 7.99e-8 Pulse pressure;Diastolic blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26767085 chr19:7977494 MAP2K7 0.44 6.1 0.35 3.74e-9 Fibrinogen levels; CESC cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg02931644 chr1:25747376 RHCE 0.38 6.25 0.36 1.67e-9 Erythrocyte sedimentation rate; CESC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg24562669 chr7:97807699 LMTK2 0.49 6.98 0.39 2.41e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs17253792 0.915 rs77161327 chr14:56178565 A/G cg01858014 chr14:56050164 KTN1 -0.94 -7.27 -0.41 4.03e-12 Putamen volume; CESC cis rs35955747 0.934 rs5997981 chr22:31808827 A/G cg25791279 chr22:32026902 PISD -0.45 -5.45 -0.32 1.14e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs7937682 0.737 rs679032 chr11:111423286 G/T cg09085632 chr11:111637200 PPP2R1B -0.78 -10.25 -0.53 5.65e-21 Primary sclerosing cholangitis; CESC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs8114671 0.562 rs6087649 chr20:33510662 A/G cg24642439 chr20:33292090 TP53INP2 0.44 5.32 0.31 2.18e-7 Height; CESC cis rs9611565 0.512 rs1534932 chr22:42150146 C/T cg17376030 chr22:41985996 PMM1 -0.78 -8.17 -0.45 1.24e-14 Vitiligo; CESC cis rs10791097 0.694 rs4436551 chr11:130755739 A/G cg12179176 chr11:130786555 SNX19 -0.65 -10.45 -0.54 1.3e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9796 0.689 rs28497404 chr15:41449510 A/C cg18705301 chr15:41695430 NDUFAF1 -0.48 -7.16 -0.4 8.13e-12 Menopause (age at onset); CESC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg04414720 chr1:150670196 GOLPH3L 0.56 7.4 0.41 1.81e-12 Melanoma; CESC cis rs9287719 0.901 rs55861579 chr2:10763340 T/A cg02196655 chr2:10830764 NOL10 -0.36 -5.44 -0.32 1.23e-7 Prostate cancer; CESC cis rs6577655 0.561 rs6577654 chr8:135593610 G/A cg17885191 chr8:135476712 NA 0.48 5.24 0.31 3.23e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC trans rs7618501 0.966 rs13085679 chr3:49869631 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.36 0.46 3.66e-15 Intelligence (multi-trait analysis); CESC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg18230493 chr5:56204884 C5orf35 -0.72 -8.76 -0.47 2.37e-16 Initial pursuit acceleration; CESC cis rs67311347 1.000 rs73078162 chr3:40477109 G/A cg24209194 chr3:40518798 ZNF619 0.51 6.2 0.36 2.18e-9 Renal cell carcinoma; CESC cis rs72634258 1.000 rs72634258 chr1:8150638 T/C cg00042356 chr1:8021962 PARK7 0.8 7.41 0.41 1.75e-12 Inflammatory bowel disease; CESC cis rs904092 0.720 rs931635 chr4:100210847 A/G cg12011299 chr4:100065546 ADH4 -0.51 -5.9 -0.34 1.11e-8 Alcohol dependence; CESC cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg18850127 chr7:39170497 POU6F2 0.36 5.06 0.3 7.92e-7 IgG glycosylation; CESC cis rs1847202 0.859 rs4501056 chr3:72948908 A/T cg10804678 chr3:72788309 NA -0.38 -5.21 -0.3 3.81e-7 Motion sickness; CESC cis rs12893668 0.703 rs34186780 chr14:104027595 T/G cg24130564 chr14:104152367 KLC1 -0.47 -5.77 -0.33 2.21e-8 Reticulocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01008941 chr4:39046077 KLHL5 -0.44 -6.29 -0.36 1.3e-9 Gambling; CESC cis rs7666738 0.830 rs35276471 chr4:99068691 A/T cg17366294 chr4:99064904 C4orf37 0.61 8.5 0.46 1.41e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9486715 0.867 rs6568428 chr6:96903604 A/G cg18709589 chr6:96969512 KIAA0776 0.46 6.52 0.37 3.61e-10 Headache; CESC cis rs6083 0.536 rs4528512 chr15:58852226 A/T cg05156742 chr15:59063176 FAM63B 0.56 7.41 0.41 1.73e-12 Schizophrenia; CESC cis rs7662987 0.517 rs2602880 chr4:100040653 C/T cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC cis rs9300255 0.663 rs7953929 chr12:123758235 C/G cg05973401 chr12:123451056 ABCB9 0.52 5.34 0.31 1.95e-7 Neutrophil percentage of white cells; CESC trans rs7944735 0.507 rs7114598 chr11:48101766 C/T cg15704280 chr7:45808275 SEPT13 0.61 7.51 0.42 9.22e-13 Intraocular pressure; CESC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg16325326 chr1:53192061 ZYG11B -0.9 -15.33 -0.69 2.02e-38 Monocyte count; CESC cis rs28489187 0.706 rs2300634 chr1:85791257 T/C cg16011679 chr1:85725395 C1orf52 0.53 6.22 0.36 1.89e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs713587 0.563 rs11686663 chr2:25107759 C/T cg01884057 chr2:25150051 NA 0.34 6.44 0.37 5.53e-10 Body mass index in non-asthmatics; CESC cis rs11098499 0.954 rs17005535 chr4:120411562 C/T cg09307838 chr4:120376055 NA 0.94 13.64 0.64 1.94e-32 Corneal astigmatism; CESC cis rs28830936 0.528 rs11630242 chr15:42124643 T/C cg17847044 chr15:42102381 MAPKBP1 -0.42 -7.02 -0.4 1.81e-11 Diastolic blood pressure; CESC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg18350739 chr11:68623251 NA -0.46 -7.1 -0.4 1.15e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg20589815 chr10:47656205 NA 0.44 6.03 0.35 5.56e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs1373453 0.808 rs80332434 chr12:70071897 T/C cg19702771 chr4:82058885 PRKG2 0.74 6.01 0.35 6.27e-9 Orofacial clefts; CESC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg06484146 chr7:12443880 VWDE -0.73 -8.75 -0.47 2.6e-16 Coronary artery disease; CESC cis rs12477438 0.798 rs9808541 chr2:99642179 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs12449964 0.524 rs7224756 chr17:17572342 G/A cg04398451 chr17:18023971 MYO15A 0.37 5.05 0.3 8.1e-7 Coronary artery disease or ischemic stroke; CESC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.88e-8 Lung cancer; CESC cis rs2120019 0.938 rs2304903 chr15:75315778 A/G cg17294928 chr15:75287854 SCAMP5 -0.79 -9.08 -0.49 2.52e-17 Blood trace element (Zn levels); CESC trans rs6089829 0.962 rs6011548 chr20:61666063 C/T cg23505145 chr19:12996616 KLF1 0.52 6.8 0.39 6.85e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs2732480 0.500 rs2450989 chr12:48653408 A/G cg04545296 chr12:48745243 ZNF641 -0.39 -6.58 -0.37 2.45e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs5753618 0.504 rs5753661 chr22:31899797 C/A cg13145458 chr22:31556086 RNF185 -0.48 -5.69 -0.33 3.28e-8 Colorectal cancer; CESC cis rs1881797 1.000 rs12071797 chr1:247686871 A/G cg11166453 chr1:247681781 NA 0.44 5.77 0.33 2.24e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg05564831 chr3:52568323 NT5DC2 0.45 5.67 0.33 3.7e-8 Bipolar disorder; CESC cis rs10463316 1.000 rs10463316 chr5:150746034 A/G cg03212797 chr5:150827313 SLC36A1 -0.45 -5.38 -0.31 1.61e-7 Metabolite levels (Pyroglutamine); CESC cis rs9815354 0.680 rs57525756 chr3:41843591 A/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00016223 chr6:36515007 STK38 0.57 6.47 0.37 4.62e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06676579 chr20:25176178 ENTPD6 0.59 6.55 0.37 2.94e-10 Gut microbiome composition (summer); CESC trans rs10242455 0.571 rs56167514 chr7:99161347 A/G cg09045935 chr12:6379348 NA 0.82 6.99 0.39 2.2e-11 Blood metabolite levels; CESC trans rs208520 0.690 rs12189780 chr6:66759619 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.16 0.6 2.56e-27 Exhaled nitric oxide output; CESC cis rs3733585 0.673 rs9994937 chr4:9964799 G/T cg11266682 chr4:10021025 SLC2A9 -0.6 -10.89 -0.56 4.59e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7188697 0.922 rs40188 chr16:58567761 T/A cg02549819 chr16:58548995 SETD6 -0.42 -5.24 -0.31 3.24e-7 QT interval; CESC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg19592336 chr6:28129416 ZNF389 0.52 7.11 0.4 1.07e-11 Depression; CESC cis rs7615952 0.800 rs11915699 chr3:125632684 A/G cg05084668 chr3:125655381 ALG1L -0.43 -5.11 -0.3 6.31e-7 Blood pressure (smoking interaction); CESC cis rs11958404 0.932 rs11949394 chr5:157425198 A/G cg05962755 chr5:157440814 NA 0.61 6.6 0.38 2.26e-10 IgG glycosylation; CESC cis rs10504229 0.679 rs2317991 chr8:58035080 C/T cg24829409 chr8:58192753 C8orf71 0.45 5.9 0.34 1.11e-8 Developmental language disorder (linguistic errors); CESC cis rs4450798 0.793 rs28454765 chr3:13758013 A/G cg05589046 chr3:13742034 LOC285375 0.39 6.1 0.35 3.76e-9 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1559088 0.948 rs7259333 chr19:33579128 T/C cg27124370 chr19:33622961 WDR88 0.47 6.2 0.36 2.2e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs3771570 0.892 rs55751610 chr2:242346057 C/T cg21155796 chr2:242212141 HDLBP 0.58 5.06 0.3 7.83e-7 Prostate cancer; CESC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg07677032 chr17:61819896 STRADA 0.46 6.18 0.35 2.43e-9 Prudent dietary pattern; CESC cis rs10504229 0.906 rs7846666 chr8:58172302 T/C cg24829409 chr8:58192753 C8orf71 -0.62 -8.69 -0.47 3.85e-16 Developmental language disorder (linguistic errors); CESC trans rs11764590 0.715 rs55810445 chr7:2103739 C/T cg11693508 chr17:37793320 STARD3 0.68 6.48 0.37 4.5e-10 Neuroticism; CESC cis rs7666738 0.830 rs11944107 chr4:98931638 G/C cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs6439153 0.743 rs71331685 chr3:128711425 T/A cg24203234 chr3:128598194 ACAD9 0.41 5.39 0.31 1.59e-7 Pneumococcal bacteremia; CESC cis rs11583043 0.708 rs11590358 chr1:101560214 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.48 0.32 9.72e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs728616 0.558 rs12767261 chr10:82162323 G/A cg05935833 chr10:81318306 SFTPA2 -0.46 -5.71 -0.33 3.09e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.3 -5.19 -0.3 4.15e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs829883 0.966 rs249815 chr12:98893709 A/G cg25150519 chr12:98850993 NA 0.71 9.74 0.51 2.31e-19 Colorectal adenoma (advanced); CESC cis rs10927875 1.000 rs3979179 chr1:16306846 A/G cg22431228 chr1:16359049 CLCNKA -0.35 -5.29 -0.31 2.53e-7 Dilated cardiomyopathy; CESC cis rs911555 0.755 rs4906329 chr14:103942669 A/G cg12935359 chr14:103987150 CKB 0.66 9.55 0.51 8.86e-19 Intelligence (multi-trait analysis); CESC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg02951883 chr7:2050386 MAD1L1 -0.48 -6.44 -0.37 5.51e-10 Bipolar disorder and schizophrenia; CESC cis rs4964805 0.606 rs7312606 chr12:104188385 C/G cg02344784 chr12:104178138 NT5DC3 0.46 6.57 0.37 2.73e-10 Attention deficit hyperactivity disorder; CESC cis rs3749237 0.595 rs35701831 chr3:49515000 A/C cg06212747 chr3:49208901 KLHDC8B 0.47 6.33 0.36 1.04e-9 Resting heart rate; CESC cis rs4919687 0.550 rs10437480 chr10:104453024 C/G cg04362960 chr10:104952993 NT5C2 0.44 5.18 0.3 4.47e-7 Colorectal cancer; CESC cis rs644799 0.965 rs598876 chr11:95560853 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.57e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg08392591 chr16:89556376 ANKRD11 0.59 8.04 0.44 3.06e-14 Multiple myeloma (IgH translocation); CESC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg26343298 chr8:95960752 TP53INP1 0.37 6.13 0.35 3.11e-9 Type 2 diabetes; CESC cis rs6598955 0.671 rs41285347 chr1:26644399 C/T cg19743891 chr1:26644573 UBXN11;CD52 0.35 5.09 0.3 6.68e-7 Obesity-related traits; CESC cis rs1348850 1.000 rs3927978 chr2:178443854 A/G cg23306229 chr2:178417860 TTC30B -0.54 -7.09 -0.4 1.2e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9733 0.744 rs4970976 chr1:150779524 T/A cg13175981 chr1:150552382 MCL1 0.52 7.14 0.4 8.93e-12 Tonsillectomy; CESC cis rs858239 0.806 rs10268610 chr7:23274764 A/G cg23682824 chr7:23144976 KLHL7 0.43 5.55 0.32 7.01e-8 Cerebrospinal fluid biomarker levels; CESC cis rs6500395 1.000 rs9933976 chr16:48590145 A/G cg04672837 chr16:48644449 N4BP1 0.51 6.42 0.37 6.2e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.44 -5.12 -0.3 6.02e-7 Breast cancer; CESC cis rs7843479 0.932 rs68023663 chr8:21794379 T/C cg17168535 chr8:21777572 XPO7 0.51 7.2 0.4 6.18e-12 Mean corpuscular volume; CESC cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg03709012 chr19:19516395 GATAD2A 1.0 14.75 0.67 2.39e-36 Tonsillectomy; CESC trans rs12310956 0.515 rs1852221 chr12:33945489 G/T cg26384229 chr12:38710491 ALG10B 0.47 6.56 0.37 2.74e-10 Morning vs. evening chronotype; CESC cis rs113835537 0.529 rs75003264 chr11:66256099 G/A cg24851651 chr11:66362959 CCS 0.53 6.26 0.36 1.57e-9 Airway imaging phenotypes; CESC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg13114125 chr14:105738426 BRF1 -0.68 -8.55 -0.47 9.7e-16 Mean platelet volume;Platelet distribution width; CESC cis rs9894429 0.646 rs9905639 chr17:79614154 A/G cg13777783 chr17:79615861 NA -0.35 -5.98 -0.34 7.27e-9 Eye color traits; CESC cis rs2408955 0.561 rs9971924 chr12:48479832 C/G cg04545296 chr12:48745243 ZNF641 -0.35 -6.1 -0.35 3.7e-9 Glycated hemoglobin levels; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg25362248 chr1:31192015 MATN1 0.48 6.35 0.36 9.41e-10 Thyroid stimulating hormone; CESC cis rs113835537 0.529 rs2305532 chr11:66298594 C/T cg22134325 chr11:66188745 NPAS4 0.39 5.94 0.34 8.94e-9 Airway imaging phenotypes; CESC cis rs921968 0.643 rs3845836 chr2:219504955 C/T cg02176678 chr2:219576539 TTLL4 0.39 6.7 0.38 1.24e-10 Mean corpuscular hemoglobin concentration; CESC cis rs4835473 0.778 rs6856553 chr4:144747126 C/T cg25736465 chr4:144833511 NA -0.35 -5.4 -0.32 1.46e-7 Immature fraction of reticulocytes; CESC cis rs7631605 0.875 rs11714125 chr3:37024256 T/C cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.09 -0.3 6.91e-7 Cerebrospinal P-tau181p levels; CESC cis rs6426558 0.537 rs10495253 chr1:227471820 A/T cg10327440 chr1:227177885 CDC42BPA 0.48 5.96 0.34 8.16e-9 Neutrophil percentage of white cells; CESC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg26408565 chr15:76604113 ETFA -0.41 -5.98 -0.34 7.19e-9 Blood metabolite levels; CESC cis rs6963495 0.818 rs9769403 chr7:105163091 G/A cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs2932538 0.883 rs6696991 chr1:113095661 C/T cg22162597 chr1:113214053 CAPZA1 0.47 6.21 0.36 2.05e-9 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Depression; CESC cis rs2985684 0.789 rs1957979 chr14:50063332 A/G cg02151108 chr14:50098012 C14orf104 -0.38 -5.03 -0.3 8.89e-7 Carotid intima media thickness; CESC cis rs7914558 0.933 rs10883814 chr10:104737404 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.67 0.33 3.68e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21164723 chr1:214776304 CENPF 0.45 6.19 0.36 2.34e-9 Gut microbiota (bacterial taxa); CESC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg17949981 chr6:28129498 ZNF389 0.42 5.48 0.32 9.8e-8 Depression; CESC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.5 -0.37 4.06e-10 Electroencephalogram traits; CESC cis rs9513593 1.000 rs12100212 chr13:99966921 C/T cg21788972 chr13:99853209 UBAC2 0.62 7.01 0.4 1.94e-11 Psoriasis; CESC cis rs1153858 0.621 rs2413769 chr15:45561868 A/C cg14582100 chr15:45693742 SPATA5L1 0.43 5.77 0.33 2.21e-8 Homoarginine levels; CESC cis rs7208859 0.673 rs73263776 chr17:29211331 G/C cg13385521 chr17:29058706 SUZ12P 0.66 5.03 0.3 9.15e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs72781680 0.898 rs72796154 chr2:23933839 G/A cg08917208 chr2:24149416 ATAD2B 1.09 10.05 0.53 2.47e-20 Lymphocyte counts; CESC cis rs7824557 0.547 rs2736287 chr8:11228006 G/A cg21775007 chr8:11205619 TDH -0.55 -8.58 -0.47 8.11e-16 Retinal vascular caliber; CESC cis rs7666738 0.830 rs13110410 chr4:98920018 T/C cg17366294 chr4:99064904 C4orf37 0.57 7.94 0.44 5.78e-14 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.964 rs854762 chr17:18009102 G/A cg04398451 chr17:18023971 MYO15A 0.69 9.7 0.51 3.1400000000000002e-19 Total body bone mineral density; CESC cis rs2180341 0.960 rs1543432 chr6:127698018 T/C cg24812749 chr6:127587940 RNF146 1.04 14.79 0.67 1.71e-36 Breast cancer; CESC cis rs6460942 0.597 rs4721107 chr7:12535105 T/G cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg21644426 chr2:191273491 MFSD6 0.48 6.43 0.37 6.04e-10 Pulse pressure; CESC cis rs9640161 0.789 rs34728606 chr7:150054694 G/A cg27494647 chr7:150038898 RARRES2 0.44 5.36 0.31 1.83e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg11905131 chr22:24372483 LOC391322 0.68 9.8 0.52 1.55e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10028773 0.600 rs4001390 chr4:120265783 G/C cg09307838 chr4:120376055 NA 0.76 10.03 0.52 2.87e-20 Educational attainment; CESC cis rs4718428 0.662 rs34577323 chr7:66310041 G/C cg18252515 chr7:66147081 NA -0.45 -5.06 -0.3 7.84e-7 Corneal structure; CESC cis rs5167 0.677 rs12709889 chr19:45453239 A/G cg13119609 chr19:45449297 APOC2 -0.39 -5.47 -0.32 1.06e-7 Blood protein levels; CESC cis rs17818399 0.612 rs4952834 chr2:46777462 C/G cg02822958 chr2:46747628 ATP6V1E2 0.42 5.45 0.32 1.17e-7 Height; CESC cis rs7872515 0.775 rs1970121 chr9:94870152 A/C cg01248375 chr9:94877805 SPTLC1 -0.56 -6.1 -0.35 3.81e-9 Bipolar disorder and schizophrenia; CESC cis rs2950393 0.929 rs2290893 chr12:57078620 A/G cg05584118 chr12:57595605 LRP1 -0.37 -5.23 -0.31 3.42e-7 Platelet distribution width; CESC cis rs7568458 0.709 rs2028898 chr2:85777270 G/A cg02493740 chr2:85810744 VAMP5 -0.57 -8.33 -0.46 4.41e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg22800045 chr5:56110881 MAP3K1 0.8 9.58 0.51 7.41e-19 Initial pursuit acceleration; CESC cis rs116095464 0.558 rs59113266 chr5:279965 T/C cg22857025 chr5:266934 NA -1.29 -18.38 -0.75 3.21e-49 Breast cancer; CESC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg11890956 chr21:40555474 PSMG1 -0.94 -15.22 -0.68 5.25e-38 Cognitive function; CESC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg21784768 chr11:537496 LRRC56 0.56 5.27 0.31 2.84e-7 Body mass index; CESC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs10871290 0.551 rs3863435 chr16:74465396 C/G cg01733217 chr16:74700730 RFWD3 -0.67 -9.16 -0.49 1.5e-17 Breast cancer; CESC cis rs2304069 1.000 rs216126 chr5:149428424 G/C cg10852222 chr5:149380144 HMGXB3;TIGD6 0.47 5.26 0.31 2.99e-7 HIV-1 control; CESC cis rs8060686 0.858 rs7199443 chr16:67841129 T/G cg26727032 chr16:67993705 SLC12A4 -0.66 -9.55 -0.51 8.9e-19 HDL cholesterol;Metabolic syndrome; CESC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg00074818 chr8:8560427 CLDN23 0.35 5.2 0.3 4e-7 Obesity-related traits; CESC cis rs763014 0.898 rs916414 chr16:632073 C/T cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC cis rs2742417 0.603 rs2742374 chr3:45784082 T/C cg04837898 chr3:45731254 SACM1L -0.46 -6.0 -0.35 6.47e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs853679 0.766 rs9368561 chr6:28168343 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.78 6.82 0.39 6.25e-11 Depression; CESC cis rs6570726 0.537 rs1280279 chr6:145884048 G/T cg05347473 chr6:146136440 FBXO30 0.58 6.06 0.35 4.72e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg06873352 chr17:61820015 STRADA 0.72 12.35 0.6 5.73e-28 Prudent dietary pattern; CESC cis rs8062405 0.755 rs62034358 chr16:28587597 G/T cg01378222 chr16:28622494 SULT1A1 0.3 5.09 0.3 6.77e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04904834 chr1:179851103 TOR1AIP1 -0.45 -6.45 -0.37 5.13e-10 Gambling; CESC cis rs6088580 0.609 rs945674 chr20:32964247 G/C cg06115741 chr20:33292138 TP53INP2 -0.46 -5.98 -0.34 7.28e-9 Glomerular filtration rate (creatinine); CESC cis rs1348850 0.914 rs6710575 chr2:178377311 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.84 11.89 0.59 1.99e-26 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs300703 0.542 rs443419 chr2:189800 C/T cg21211680 chr2:198530 NA -0.86 -9.39 -0.5 2.94e-18 Blood protein levels; CESC cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs919433 0.680 rs67580728 chr2:198431258 C/T cg03934865 chr2:198174659 NA 0.37 5.06 0.3 7.77e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs8005677 1.000 rs4982710 chr14:23398902 C/T cg25600027 chr14:23388339 RBM23 -0.42 -5.11 -0.3 6.27e-7 Cognitive ability (multi-trait analysis); CESC cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg11366901 chr6:160182831 ACAT2 0.84 11.06 0.56 1.28e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs2929278 0.561 rs3099045 chr15:43923955 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.47 7.23 0.41 5.15e-12 Schizophrenia; CESC cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg19193384 chr17:30244184 NA -0.69 -6.15 -0.35 2.92e-9 Hip circumference adjusted for BMI; CESC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg00080972 chr5:178986291 RUFY1 -0.48 -7.76 -0.43 1.8e-13 Lung cancer; CESC cis rs2996428 0.628 rs6667526 chr1:3774603 G/A cg23277830 chr1:3704460 LRRC47 0.35 5.22 0.31 3.6e-7 Red cell distribution width; CESC cis rs17401966 1.000 rs1049887 chr1:10460485 T/C cg15208524 chr1:10270712 KIF1B 0.48 6.04 0.35 5.3e-9 Hepatocellular carcinoma; CESC cis rs9649465 1.000 rs3807635 chr7:123382152 A/C cg04330084 chr7:123175371 IQUB -0.38 -5.06 -0.3 8.01e-7 Migraine; CESC cis rs367615 0.552 rs2963010 chr5:108737043 T/C cg17395555 chr5:108820864 NA -0.52 -8.5 -0.46 1.36e-15 Colorectal cancer (SNP x SNP interaction); CESC cis rs2011503 1.000 rs7256028 chr19:19628240 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.49 5.09 0.3 6.83e-7 Bipolar disorder; CESC cis rs2276314 1.000 rs1540042 chr18:33555236 C/T cg19628046 chr18:33552617 C18orf21 0.56 6.32 0.36 1.12e-9 Endometriosis;Drug-induced torsades de pointes; CESC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg06481639 chr22:41940642 POLR3H -0.61 -6.49 -0.37 4.09e-10 Vitiligo; CESC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.91 13.98 0.65 1.24e-33 Prudent dietary pattern; CESC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg08736216 chr1:53307985 ZYG11A -0.45 -7.32 -0.41 2.94e-12 Monocyte count; CESC cis rs12701220 0.522 rs12334290 chr7:1054517 A/G cg20821713 chr7:1055600 C7orf50 -0.5 -6.5 -0.37 4.04e-10 Bronchopulmonary dysplasia; CESC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg26354017 chr1:205819088 PM20D1 0.83 13.36 0.63 1.77e-31 Menarche (age at onset); CESC cis rs5769765 0.908 rs9627800 chr22:50319351 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.62 -6.38 -0.37 7.75e-10 Schizophrenia; CESC cis rs2066819 1.000 rs744051 chr12:56667298 C/T cg26714650 chr12:56694279 CS 1.35 9.44 0.5 2.01e-18 Psoriasis vulgaris; CESC cis rs7216064 1.000 rs12602655 chr17:65909442 A/G cg07042672 chr17:66097459 LOC651250 -0.52 -5.35 -0.31 1.9e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7786877 0.680 rs28584500 chr7:100216341 G/A cg16850897 chr7:100343110 ZAN -0.58 -6.23 -0.36 1.83e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7659604 0.521 rs4833232 chr4:122684367 C/T cg19671926 chr4:122722719 EXOSC9 0.6 7.64 0.42 4e-13 Type 2 diabetes; CESC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.58 -0.37 2.56e-10 Bipolar disorder; CESC trans rs637571 0.522 rs491973 chr11:65727301 A/G cg17712092 chr4:129076599 LARP1B 0.7 9.65 0.51 4.53e-19 Eosinophil percentage of white cells; CESC trans rs61931739 0.500 rs11053218 chr12:34474792 A/C cg26384229 chr12:38710491 ALG10B -0.66 -9.5 -0.5 1.3e-18 Morning vs. evening chronotype; CESC cis rs67311347 0.866 rs11712426 chr3:40330322 G/A cg09455208 chr3:40491958 NA 0.43 7.12 0.4 1.02e-11 Renal cell carcinoma; CESC cis rs7582720 1.000 rs72926783 chr2:203815740 T/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs66686620 0.943 rs6546472 chr2:69260300 A/G cg12800200 chr2:69260302 ANTXR1 -0.44 -6.48 -0.37 4.34e-10 Breast cancer; CESC cis rs2880765 0.835 rs28874135 chr15:86031503 G/A cg10818794 chr15:86012489 AKAP13 -0.35 -5.42 -0.32 1.32e-7 Coronary artery disease; CESC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg26314531 chr2:26401878 FAM59B -0.62 -6.99 -0.39 2.29e-11 Gut microbiome composition (summer); CESC cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg21138405 chr5:131827807 IRF1 -0.4 -5.88 -0.34 1.25e-8 Breast cancer;Mosquito bite size; CESC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.83 0.65 4.07e-33 Prudent dietary pattern; CESC cis rs3733585 0.673 rs4467563 chr4:9953460 A/T cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7772486 0.754 rs4360151 chr6:146255079 A/C cg05347473 chr6:146136440 FBXO30 -0.52 -6.88 -0.39 4.23e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg20891558 chr2:74357851 NA 0.84 10.44 0.54 1.35e-21 Gestational age at birth (maternal effect); CESC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.87 11.27 0.57 2.42e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24327389 chr8:11882982 NA -0.47 -6.66 -0.38 1.61e-10 Gut microbiota (bacterial taxa); CESC cis rs2439831 0.850 rs28413881 chr15:44174099 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.64 6.52 0.37 3.62e-10 Lung cancer in ever smokers; CESC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg03576123 chr11:487126 PTDSS2 -1.12 -11.17 -0.57 5.31e-24 Body mass index; CESC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg13147721 chr7:65941812 NA -0.6 -6.44 -0.37 5.49e-10 Diabetic kidney disease; CESC cis rs7772486 0.701 rs2244308 chr6:146213706 C/T cg23711669 chr6:146136114 FBXO30 0.82 11.64 0.58 1.47e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs16910800 0.731 rs16910754 chr11:23192015 A/G cg20040320 chr11:23191996 NA 0.6 5.98 0.34 7.28e-9 Cancer; CESC cis rs3858526 0.959 rs10838901 chr11:5959128 G/A cg05234568 chr11:5960015 NA -0.62 -6.78 -0.38 7.84e-11 DNA methylation (variation); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18149561 chr19:13905866 ZSWIM4 -0.47 -6.44 -0.37 5.44e-10 Fibrinogen levels; CESC cis rs2249625 0.874 rs2254147 chr6:72920943 C/G cg18830697 chr6:72922368 RIMS1 -0.4 -5.76 -0.33 2.38e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs7917772 0.599 rs2863717 chr10:104519829 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -5.1 -0.3 6.44e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22647065 chr19:19612767 GATAD2A -0.56 -6.24 -0.36 1.74e-9 Gut microbiome composition (summer); CESC cis rs6089584 1.000 rs6089584 chr20:60564086 G/C cg06108461 chr20:60628389 TAF4 -0.78 -11.45 -0.58 6.38e-25 Body mass index; CESC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg15369054 chr17:80825471 TBCD 0.38 5.52 0.32 8e-8 Breast cancer; CESC cis rs262150 0.672 rs2730230 chr7:158788529 A/G cg19418458 chr7:158789849 NA -0.4 -6.3 -0.36 1.26e-9 Facial morphology (factor 20); CESC cis rs35110281 0.627 rs11701746 chr21:44975137 C/T cg04455712 chr21:45112962 RRP1B 0.36 5.42 0.32 1.37e-7 Mean corpuscular volume; CESC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg07507251 chr3:52567010 NT5DC2 0.32 5.6 0.33 5.34e-8 Electroencephalogram traits; CESC cis rs7847628 0.587 rs10760117 chr9:123586737 T/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 7.78 0.43 1.61e-13 Birth weight; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13334819 chr7:99746414 C7orf59 0.6 6.94 0.39 2.97e-11 Gut microbiome composition (summer); CESC cis rs9660992 0.547 rs12143121 chr1:205199142 A/G cg21643547 chr1:205240462 TMCC2 -0.39 -5.51 -0.32 8.53e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg18230493 chr5:56204884 C5orf35 0.69 8.07 0.44 2.39e-14 Initial pursuit acceleration; CESC trans rs945270 0.512 rs10148235 chr14:56195565 T/C cg18102697 chr4:83542773 C4orf11 -0.43 -6.41 -0.37 6.52e-10 Subcortical brain region volumes; CESC cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg20891283 chr12:69753455 YEATS4 1.0 17.29 0.73 2.3e-45 Cerebrospinal fluid biomarker levels; CESC cis rs6456156 0.565 rs6921588 chr6:167494397 G/T cg07741184 chr6:167504864 NA 0.41 6.55 0.37 3.06e-10 Primary biliary cholangitis; CESC cis rs6942756 1.000 rs73472312 chr7:128925217 T/C cg02491457 chr7:128862824 NA -0.67 -8.86 -0.48 1.2e-16 White matter hyperintensity burden; CESC cis rs9486715 0.867 rs2499774 chr6:97006581 C/G cg18709589 chr6:96969512 KIAA0776 -0.45 -6.32 -0.36 1.1e-9 Headache; CESC cis rs7904368 0.806 rs7087360 chr10:16872337 C/A cg14835575 chr10:16859367 RSU1 0.48 5.13 0.3 5.58e-7 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs123509 0.913 rs123506 chr3:42775976 T/C cg12982090 chr3:42733453 KBTBD5 0.7 8.39 0.46 2.89e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6582630 0.555 rs10880613 chr12:38509553 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.69 0.38 1.35e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs1182196 0.533 rs2527521 chr7:2904928 A/G cg09658497 chr7:2847517 GNA12 0.35 5.33 0.31 2.06e-7 Plateletcrit; CESC cis rs11792861 0.926 rs72607163 chr9:111803128 G/T cg13535736 chr9:111863775 C9orf5 -0.5 -6.57 -0.37 2.63e-10 Menarche (age at onset); CESC cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg24642439 chr20:33292090 TP53INP2 -0.64 -8.35 -0.46 3.79e-15 Coronary artery disease; CESC trans rs72766638 0.895 rs72766630 chr9:136926791 G/T cg10765909 chr12:53715428 AAAS -0.73 -6.54 -0.37 3.18e-10 Mosquito bite size; CESC cis rs73206853 0.764 rs60027620 chr12:111103669 T/G cg12870014 chr12:110450643 ANKRD13A 0.65 5.48 0.32 9.72e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg18196295 chr10:418757 DIP2C 0.52 7.01 0.4 2.01e-11 Psychosis in Alzheimer's disease; CESC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.92 9.97 0.52 4.46e-20 Mean platelet volume; CESC cis rs6426558 0.502 rs10916080 chr1:227232040 A/G cg10327440 chr1:227177885 CDC42BPA 0.53 6.51 0.37 3.79e-10 Neutrophil percentage of white cells; CESC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg09455208 chr3:40491958 NA 0.41 6.84 0.39 5.6e-11 Renal cell carcinoma; CESC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg07507251 chr3:52567010 NT5DC2 0.32 5.49 0.32 9.27e-8 Intelligence (multi-trait analysis); CESC cis rs763014 0.931 rs2071981 chr16:630025 C/G cg07256732 chr16:621771 PIGQ -0.31 -5.38 -0.31 1.61e-7 Height; CESC cis rs4243830 0.510 rs7518459 chr1:6596678 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.98 -9.94 -0.52 5.48e-20 Body mass index; CESC cis rs1577917 0.771 rs9294337 chr6:86248460 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.55 7.67 0.43 3.2e-13 Response to antipsychotic treatment; CESC cis rs6502050 0.761 rs9908277 chr17:80060829 T/C cg23985595 chr17:80112537 CCDC57 0.41 6.27 0.36 1.49e-9 Life satisfaction; CESC trans rs17685 0.633 rs3801471 chr7:75696188 T/G cg19862616 chr7:65841803 NCRNA00174 0.86 12.43 0.61 2.86e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg07507251 chr3:52567010 NT5DC2 -0.39 -6.87 -0.39 4.44e-11 Bipolar disorder; CESC cis rs10751667 0.666 rs7934963 chr11:957220 C/T cg06064525 chr11:970664 AP2A2 -0.49 -9.81 -0.52 1.38e-19 Alzheimer's disease (late onset); CESC cis rs11958404 0.932 rs72816542 chr5:157416402 C/T cg05962755 chr5:157440814 NA 0.62 6.47 0.37 4.68e-10 IgG glycosylation; CESC trans rs634534 0.622 rs531612 chr11:65705432 C/T cg17712092 chr4:129076599 LARP1B -0.65 -8.31 -0.45 4.97e-15 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg04450456 chr4:17643702 FAM184B -0.37 -5.29 -0.31 2.51e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2439831 0.850 rs56909447 chr15:44137618 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.66 6.03 0.35 5.4e-9 Lung cancer in ever smokers; CESC cis rs10465746 0.935 rs4258241 chr1:84437929 G/A cg10977910 chr1:84465055 TTLL7 0.47 6.32 0.36 1.13e-9 Obesity-related traits; CESC cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.79 8.79 0.47 1.98e-16 Alzheimer's disease; CESC cis rs17253792 0.558 rs10083353 chr14:56066370 G/T cg01858014 chr14:56050164 KTN1 -0.86 -6.7 -0.38 1.21e-10 Putamen volume; CESC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg01416388 chr22:39784598 NA 0.58 7.37 0.41 2.2e-12 Intelligence (multi-trait analysis); CESC cis rs11785400 0.793 rs13248524 chr8:143739343 T/C cg24634471 chr8:143751801 JRK 0.45 5.75 0.33 2.41e-8 Schizophrenia; CESC cis rs4472734 1.000 rs6540832 chr1:214627139 G/A cg00063699 chr1:214624242 PTPN14 -0.33 -5.05 -0.3 8.33e-7 Height; CESC cis rs9388451 0.874 rs9398787 chr6:126090608 A/G cg10911889 chr6:126070802 HEY2 0.39 5.38 0.31 1.62e-7 Brugada syndrome; CESC cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.45 -7.38 -0.41 2.07e-12 Hemoglobin concentration; CESC cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.29 0.31 2.52e-7 Personality dimensions; CESC cis rs7274811 0.711 rs291689 chr20:32003974 A/G cg21523528 chr20:32077966 CBFA2T2 -0.53 -6.25 -0.36 1.66e-9 Height; CESC cis rs16854884 0.710 rs1867607 chr3:143809274 T/C cg01302019 chr3:143689584 C3orf58 -0.33 -5.05 -0.3 8.1e-7 Economic and political preferences (feminism/equality); CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.72 -0.33 2.89e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs79839061 0.636 rs73207778 chr4:836762 C/T cg07828340 chr4:882639 GAK 0.83 5.73 0.33 2.7e-8 Intelligence (multi-trait analysis); CESC cis rs7772486 0.790 rs9390365 chr6:146235626 A/G cg05347473 chr6:146136440 FBXO30 -0.57 -7.31 -0.41 3.07e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs959260 1.000 rs2033607 chr17:73367288 A/G cg12999837 chr17:73267436 MIF4GD -0.46 -5.63 -0.33 4.55e-8 Systemic lupus erythematosus; CESC cis rs4660306 0.672 rs534534 chr1:46024701 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.6 -0.42 5.15e-13 Homocysteine levels; CESC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg21782813 chr7:2030301 MAD1L1 0.53 7.71 0.43 2.54e-13 Bipolar disorder and schizophrenia; CESC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg08470875 chr2:26401718 FAM59B 0.75 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC cis rs116979167 0.514 rs1706915 chr7:105196437 A/G cg13798780 chr7:105162888 PUS7 0.52 6.29 0.36 1.28e-9 Bipolar disorder (body mass index interaction); CESC cis rs6968419 0.755 rs3807983 chr7:115898991 T/C cg02561103 chr7:115862891 TES -0.41 -5.42 -0.32 1.37e-7 Intraocular pressure; CESC cis rs7666738 0.791 rs62318641 chr4:98816964 T/C cg17366294 chr4:99064904 C4orf37 0.52 6.98 0.39 2.3e-11 Colonoscopy-negative controls vs population controls; CESC cis rs10479542 0.683 rs7380706 chr5:178961872 C/T cg05457628 chr5:178986728 RUFY1 0.37 5.06 0.3 7.91e-7 Lung cancer; CESC cis rs8072100 0.651 rs1912484 chr17:45443664 C/G cg25173405 chr17:45401733 C17orf57 -0.44 -5.48 -0.32 9.98e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7208859 0.673 rs73277984 chr17:29196133 T/C cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg00255919 chr5:131827918 IRF1 -0.55 -9.23 -0.49 8.9e-18 Asthma (sex interaction); CESC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.29 0.57 2.21e-24 Alzheimer's disease; CESC cis rs7809950 1.000 rs2107713 chr7:107232369 C/T cg23024343 chr7:107201750 COG5 -0.4 -5.26 -0.31 3e-7 Coronary artery disease; CESC cis rs4662945 0.603 rs1453147 chr2:130271510 A/C cg05962382 chr2:130345044 NA -0.42 -5.94 -0.34 9.16e-9 Response to cytidine analogues (gemcitabine); CESC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg24675658 chr1:53192096 ZYG11B 0.56 7.0 0.4 2.04e-11 Monocyte count; CESC cis rs921968 0.643 rs532475 chr2:219434208 C/T cg02176678 chr2:219576539 TTLL4 0.41 7.15 0.4 8.68e-12 Mean corpuscular hemoglobin concentration; CESC cis rs367943 0.799 rs10057321 chr5:112974729 A/G cg12552261 chr5:112820674 MCC 0.54 6.14 0.35 2.99e-9 Type 2 diabetes; CESC cis rs2439831 0.681 rs7168940 chr15:43633334 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.85 12.61 0.61 7.13e-29 Lung cancer in ever smokers; CESC cis rs910316 1.000 rs12889309 chr14:75593902 C/T cg08847533 chr14:75593920 NEK9 1.02 20.32 0.78 5.6e-56 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08151832 chr16:66835414 CCDC79 -0.75 -8.9 -0.48 9.32e-17 Gut microbiome composition (summer); CESC cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg11366901 chr6:160182831 ACAT2 0.76 9.59 0.51 7.1e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs2731664 0.721 rs2450333 chr5:176899546 G/A cg23176889 chr5:176863531 GRK6 -0.64 -11.42 -0.57 7.61e-25 Intelligence (multi-trait analysis); CESC cis rs17376456 0.569 rs6556839 chr5:93206292 T/C cg25358565 chr5:93447407 FAM172A -0.7 -7.43 -0.42 1.45e-12 Diabetic retinopathy; CESC cis rs17253792 0.822 rs77415412 chr14:56154146 A/G cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC trans rs561341 1.000 rs2344312 chr17:30243583 G/T cg20587970 chr11:113659929 NA -0.83 -10.33 -0.54 3.1e-21 Hip circumference adjusted for BMI; CESC trans rs877282 0.797 rs11253329 chr10:753200 A/T cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg11766577 chr21:47581405 C21orf56 -0.46 -6.23 -0.36 1.84e-9 Testicular germ cell tumor; CESC cis rs7605827 0.930 rs6431709 chr2:15638296 T/C cg19274914 chr2:15703543 NA 0.34 6.03 0.35 5.48e-9 Educational attainment (years of education); CESC cis rs1348850 0.632 rs11682717 chr2:178499240 C/G cg23306229 chr2:178417860 TTC30B 0.6 7.47 0.42 1.17e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.64 0.42 4.02e-13 Bipolar disorder; CESC trans rs11250098 0.574 rs4554431 chr8:10771638 T/A cg15556689 chr8:8085844 FLJ10661 -0.55 -6.79 -0.38 7.52e-11 Morning vs. evening chronotype; CESC cis rs7274811 0.681 rs291674 chr20:31954890 C/G cg21523528 chr20:32077966 CBFA2T2 -0.53 -6.27 -0.36 1.48e-9 Height; CESC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg05617483 chr15:76483344 C15orf27 0.4 5.42 0.32 1.34e-7 Blood metabolite levels; CESC cis rs12900413 0.603 rs12907030 chr15:90301439 C/T cg24249390 chr15:90295951 MESP1 -0.4 -5.36 -0.31 1.79e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs12477438 0.798 rs6740267 chr2:99561867 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.77 -0.55 1.13e-22 Chronic sinus infection; CESC cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -5.13 -0.3 5.49e-7 Personality dimensions; CESC cis rs1595825 0.945 rs59553483 chr2:198855201 T/C cg00982548 chr2:198649783 BOLL -0.46 -5.26 -0.31 2.96e-7 Ulcerative colitis; CESC cis rs818427 0.896 rs458451 chr5:112224331 T/C cg07820702 chr5:112228657 REEP5 -0.43 -5.36 -0.31 1.85e-7 Total body bone mineral density; CESC cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg06970220 chr1:156163860 SLC25A44 0.39 5.23 0.31 3.48e-7 Testicular germ cell tumor; CESC cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg10074409 chr1:209979377 IRF6 0.4 6.3 0.36 1.2e-9 Cleft lip with or without cleft palate; CESC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg12463550 chr7:65579703 CRCP 0.55 6.86 0.39 4.77e-11 Aortic root size; CESC cis rs4595586 0.545 rs7308161 chr12:39363459 A/G cg26384229 chr12:38710491 ALG10B 0.47 6.59 0.38 2.39e-10 Morning vs. evening chronotype; CESC cis rs793571 0.590 rs347115 chr15:59082959 C/T cg05156742 chr15:59063176 FAM63B 0.63 8.29 0.45 5.64e-15 Schizophrenia; CESC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg22535103 chr8:58192502 C8orf71 -0.9 -8.95 -0.48 6.29e-17 Developmental language disorder (linguistic errors); CESC cis rs546131 0.928 rs535719 chr11:34853382 A/G cg11058730 chr11:34937778 PDHX;APIP 0.53 6.88 0.39 4.38e-11 Lung disease severity in cystic fibrosis; CESC cis rs13114435 0.723 rs17331744 chr4:183815561 T/C cg00486011 chr4:183851557 NA 0.37 5.37 0.31 1.76e-7 Obesity-related traits; CESC cis rs853679 0.607 rs17763089 chr6:27835218 G/A cg18032046 chr6:28092343 ZSCAN16 -0.75 -5.22 -0.31 3.68e-7 Depression; CESC trans rs6693388 0.647 rs2999508 chr1:151934447 A/C cg26164907 chr7:155616192 NA -0.31 -6.12 -0.35 3.43e-9 Blood metabolite ratios; CESC cis rs936229 0.690 rs2445618 chr15:75035256 T/C cg14664628 chr15:75095509 CSK -0.8 -10.89 -0.56 4.5e-23 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.78 0.47 2.04e-16 Bipolar disorder; CESC cis rs965469 1.000 rs1040727 chr20:3264292 G/A cg25506879 chr20:3388711 C20orf194 -0.58 -6.06 -0.35 4.6e-9 IFN-related cytopenia; CESC cis rs2066819 1.000 rs79750959 chr12:56702012 C/A cg26734620 chr12:56694298 CS 1.03 6.25 0.36 1.65e-9 Psoriasis vulgaris; CESC cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg00406319 chr10:126851303 NA -0.47 -7.55 -0.42 6.88e-13 Menarche (age at onset); CESC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg17372223 chr3:52568218 NT5DC2 0.43 6.43 0.37 5.88e-10 Bipolar disorder; CESC cis rs7520050 0.966 rs6672898 chr1:46290588 G/A cg03146154 chr1:46216737 IPP -0.47 -6.15 -0.35 2.87e-9 Red blood cell count;Reticulocyte count; CESC cis rs113835537 0.529 rs11227510 chr11:66281220 T/C cg24851651 chr11:66362959 CCS 0.45 5.55 0.32 6.92e-8 Airway imaging phenotypes; CESC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg07648498 chr16:89883185 FANCA -0.42 -5.07 -0.3 7.51e-7 Vitiligo; CESC cis rs2011503 1.000 rs34667451 chr19:19617017 C/T cg11584989 chr19:19387371 SF4 0.62 7.13 0.4 9.66e-12 Bipolar disorder; CESC cis rs735860 0.572 rs186003 chr6:53185124 A/C cg10236188 chr6:53219634 NA 0.35 5.21 0.3 3.89e-7 Glaucoma; CESC cis rs7107174 0.892 rs10899490 chr11:78105879 C/T cg02023728 chr11:77925099 USP35 0.39 5.4 0.31 1.49e-7 Testicular germ cell tumor; CESC cis rs9399401 0.710 rs7765770 chr6:142687305 C/T cg04461802 chr6:142623433 GPR126 0.36 5.31 0.31 2.29e-7 Chronic obstructive pulmonary disease; CESC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg11890956 chr21:40555474 PSMG1 0.61 8.63 0.47 5.77e-16 Menarche (age at onset); CESC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg02776659 chr21:47717406 C21orf57 -0.37 -5.1 -0.3 6.38e-7 Testicular germ cell tumor; CESC cis rs863345 0.584 rs6657638 chr1:158497184 C/G cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.78e-11 Pneumococcal bacteremia; CESC cis rs477692 0.673 rs487120 chr10:131367552 C/T cg05714579 chr10:131428358 MGMT 0.44 5.73 0.33 2.69e-8 Response to temozolomide; CESC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg07677032 chr17:61819896 STRADA 0.41 5.17 0.3 4.59e-7 Height; CESC cis rs2880765 0.835 rs4843062 chr15:86040137 A/G cg19183879 chr15:85880815 NA -0.26 -5.38 -0.31 1.6e-7 Coronary artery disease; CESC cis rs6831352 0.918 rs28987088 chr4:100059139 T/C cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs941873 0.900 rs4979861 chr10:81131595 A/G cg09469691 chr10:81107165 PPIF 0.54 7.07 0.4 1.36e-11 Height; CESC cis rs7809799 1.000 rs7809799 chr7:98760504 G/A cg05967295 chr7:98741636 SMURF1 -0.78 -5.45 -0.32 1.17e-7 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06376129 chr1:205180539 DSTYK -0.42 -6.04 -0.35 5.29e-9 Fibrinogen levels; CESC cis rs1256061 0.603 rs1256045 chr14:64729760 A/C cg23250157 chr14:64679961 SYNE2 0.53 7.64 0.42 4.09e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg11301795 chr4:187892539 NA -0.75 -12.33 -0.6 6.74e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs8114671 0.562 rs6087642 chr20:33468306 T/C cg24642439 chr20:33292090 TP53INP2 0.42 5.16 0.3 4.83e-7 Height; CESC cis rs7834588 0.523 rs4512370 chr8:63829835 C/T cg20602954 chr8:63776762 NKAIN3 0.3 5.04 0.3 8.69e-7 Response to Vitamin E supplementation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06866400 chr6:143771904 ADAT2;PEX3 0.61 7.16 0.4 8.03e-12 Gut microbiome composition (summer); CESC cis rs6500395 1.000 rs2355297 chr16:48685338 T/C cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4523957 0.579 rs903161 chr17:2092006 A/T cg16513277 chr17:2031491 SMG6 -0.62 -8.71 -0.47 3.3e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2404618 0.624 rs4338133 chr8:1477507 T/C cg13402656 chr8:1511478 DLGAP2 -0.52 -7.23 -0.41 5.24e-12 Lung cancer; CESC cis rs2658782 0.507 rs4457713 chr11:93037430 C/T cg15737290 chr11:93063684 CCDC67 0.52 7.21 0.4 5.96e-12 Pulmonary function decline; CESC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg18876405 chr7:65276391 NA -0.53 -7.38 -0.41 2.09e-12 Aortic root size; CESC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg12412775 chr1:25698385 RHCE 0.3 5.31 0.31 2.36e-7 Erythrocyte sedimentation rate; CESC cis rs7772486 0.875 rs9322046 chr6:146393625 A/G cg05347473 chr6:146136440 FBXO30 0.5 6.92 0.39 3.47e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4906332 1.000 rs17617832 chr14:103943140 T/C cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.49e-10 Coronary artery disease; CESC cis rs17376456 0.825 rs10053405 chr5:93275403 A/G cg25358565 chr5:93447407 FAM172A -1.08 -9.43 -0.5 2.2e-18 Diabetic retinopathy; CESC cis rs9914988 0.943 rs9907178 chr17:27124307 G/C cg20469991 chr17:27169893 C17orf63 -0.47 -5.18 -0.3 4.35e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs6121246 0.909 rs6089058 chr20:30326338 T/G cg13852791 chr20:30311386 BCL2L1 0.82 8.74 0.47 2.63e-16 Mean corpuscular hemoglobin; CESC cis rs2933343 0.679 rs789254 chr3:128574593 A/G cg25356066 chr3:128598488 ACAD9 0.6 8.4 0.46 2.69e-15 IgG glycosylation; CESC cis rs67311347 0.910 rs7651204 chr3:40512835 C/T cg09455208 chr3:40491958 NA -0.49 -8.32 -0.46 4.59e-15 Renal cell carcinoma; CESC cis rs7223966 1.000 rs15637 chr17:61772050 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.44 0.42 1.42e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs362272 0.545 rs2749785 chr4:3325179 G/C cg14583973 chr4:3374767 RGS12 0.33 5.7 0.33 3.26e-8 Serum sulfate level; CESC cis rs1023500 0.573 rs6002592 chr22:42476754 A/C cg15557168 chr22:42548783 NA 0.44 6.19 0.36 2.31e-9 Schizophrenia; CESC cis rs3815700 1.000 rs8113165 chr19:33096316 C/T cg02997394 chr19:33096574 ANKRD27 0.71 7.28 0.41 3.78e-12 Eosinophilic esophagitis; CESC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg03709012 chr19:19516395 GATAD2A 0.96 14.18 0.66 2.35e-34 Tonsillectomy; CESC cis rs9611565 0.649 rs202645 chr22:41798520 A/G cg03806693 chr22:41940476 POLR3H 1.2 14.89 0.68 7.3e-37 Vitiligo; CESC cis rs7666738 0.830 rs7659420 chr4:98878714 G/C cg17366294 chr4:99064904 C4orf37 0.56 7.84 0.43 1.13e-13 Colonoscopy-negative controls vs population controls; CESC trans rs17181170 0.595 rs6798262 chr3:87208779 A/T ch.2.199792288R chr2:200084043 NA -0.46 -6.02 -0.35 5.93e-9 Prostate cancer; CESC cis rs5753618 0.583 rs5753612 chr22:31821479 T/C cg13145458 chr22:31556086 RNF185 -0.5 -5.96 -0.34 7.96e-9 Colorectal cancer; CESC cis rs2880765 0.835 rs11633604 chr15:86031579 T/G cg10818794 chr15:86012489 AKAP13 -0.35 -5.42 -0.32 1.32e-7 Coronary artery disease; CESC cis rs3740713 1.000 rs75740864 chr11:18470689 C/G cg23797887 chr11:18477753 LDHAL6A -0.52 -5.1 -0.3 6.32e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs367943 0.603 rs1864066 chr5:112997865 C/T cg12552261 chr5:112820674 MCC 0.45 5.78 0.33 2.08e-8 Type 2 diabetes; CESC cis rs9911578 0.904 rs7209253 chr17:56908987 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC cis rs6502050 0.835 rs67149434 chr17:80128007 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.61e-10 Life satisfaction; CESC cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 6.1e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs2235642 0.685 rs2667681 chr16:1653206 C/T cg03771183 chr16:1608904 IFT140 0.38 5.56 0.32 6.72e-8 Coronary artery disease; CESC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg12419862 chr22:24373484 LOC391322 -0.72 -9.94 -0.52 5.32e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7772486 0.875 rs6570738 chr6:146412695 G/A cg23711669 chr6:146136114 FBXO30 0.77 11.23 0.57 3.4e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg07308232 chr7:1071921 C7orf50 -0.41 -5.46 -0.32 1.12e-7 Longevity;Endometriosis; CESC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg24642844 chr7:1081250 C7orf50 -0.76 -9.26 -0.49 7.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs250677 0.687 rs384979 chr5:148459267 C/T cg18129178 chr5:148520854 ABLIM3 0.51 5.99 0.35 6.91e-9 Breast cancer; CESC cis rs5769707 0.681 rs135879 chr22:50018651 C/T cg20744362 chr22:50050164 C22orf34 0.39 6.07 0.35 4.52e-9 Monocyte count;Monocyte percentage of white cells; CESC cis rs16857609 0.564 rs12232972 chr2:218257272 C/T cg15335768 chr2:218268053 DIRC3 -0.4 -5.69 -0.33 3.32e-8 Breast cancer;Breast cancer (estrogen-receptor negative); CESC cis rs10089 0.953 rs4836359 chr5:127385518 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.15 0.53 1.14e-20 Ileal carcinoids; CESC cis rs6032067 0.929 rs34412950 chr20:43805132 C/A cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.63e-8 Blood protein levels; CESC cis rs854765 0.583 rs4077198 chr17:17834563 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.17 0.45 1.29e-14 Total body bone mineral density; CESC trans rs17764205 0.777 rs10424519 chr19:3253532 C/G cg22364819 chr2:127864926 BIN1 -0.7 -6.01 -0.35 6.17e-9 Bipolar disorder and schizophrenia; CESC cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC cis rs4790333 0.845 rs7210932 chr17:2272024 A/G cg02569219 chr17:2266849 SGSM2 -0.48 -6.82 -0.39 6.18e-11 Proinsulin levels; CESC cis rs45535039 1.000 rs7946919 chr11:119140832 A/G cg16724696 chr11:118992527 HINFP 0.44 5.32 0.31 2.2e-7 Plateletcrit; CESC cis rs8062405 1.000 rs55991577 chr16:28843025 C/T cg08761264 chr16:28874980 SH2B1 -0.45 -5.67 -0.33 3.78e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2985684 0.901 rs57119148 chr14:50097226 T/C cg02151108 chr14:50098012 C14orf104 -0.41 -5.48 -0.32 9.72e-8 Carotid intima media thickness; CESC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.61 5.89 0.34 1.14e-8 Cerebrospinal P-tau181p levels; CESC cis rs6493487 0.512 rs80355962 chr15:51142997 C/T cg02338191 chr15:51200825 AP4E1 0.58 5.73 0.33 2.69e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9325144 0.647 rs11168819 chr12:39011082 C/A cg26384229 chr12:38710491 ALG10B -0.54 -7.52 -0.42 8.38e-13 Morning vs. evening chronotype; CESC cis rs3820928 1.000 rs61067328 chr2:227761256 G/A cg05526886 chr2:227700861 RHBDD1 -0.42 -5.37 -0.31 1.69e-7 Pulmonary function; CESC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.52 -0.37 3.5e-10 Life satisfaction; CESC cis rs7208859 0.623 rs60890550 chr17:29030861 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.17 0.35 2.5e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7116495 0.609 rs1541304 chr11:71714078 T/C cg26138937 chr11:71823887 C11orf51 -1.31 -8.57 -0.47 8.45e-16 Severe influenza A (H1N1) infection; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09373211 chr1:154193749 C1orf43;UBAP2L 0.49 6.2 0.36 2.21e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00862481 chr16:29998852 TAOK2 0.48 6.84 0.39 5.41e-11 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18229107 chr14:64854676 MTHFD1 0.58 6.2 0.36 2.17e-9 Gut microbiome composition (summer); CESC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg09359103 chr1:154839909 KCNN3 0.71 13.61 0.64 2.38e-32 Prostate cancer; CESC cis rs34779708 0.931 rs34876468 chr10:35424450 G/A cg04310649 chr10:35416472 CREM -0.5 -6.04 -0.35 5.31e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7631605 0.875 rs56304874 chr3:37245983 G/T cg22985146 chr3:37219077 LRRFIP2 -0.35 -5.64 -0.33 4.33e-8 Cerebrospinal P-tau181p levels; CESC cis rs751837 0.591 rs10138133 chr14:103424897 A/G cg10087771 chr14:103399429 CDC42BPB 0.54 5.13 0.3 5.73e-7 Large B-cell lymphoma; CESC cis rs7264396 0.616 rs6142476 chr20:34581216 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.69 -8.75 -0.47 2.58e-16 Total cholesterol levels; CESC cis rs9987353 0.589 rs1053036 chr8:9060077 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -6.71 -0.38 1.14e-10 Recombination measurement; CESC cis rs10129255 0.500 rs34326748 chr14:107190760 G/C cg07958169 chr14:107095056 NA -0.54 -8.29 -0.45 5.63e-15 Kawasaki disease; CESC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg02931644 chr1:25747376 RHCE -0.4 -6.53 -0.37 3.35e-10 Erythrocyte sedimentation rate; CESC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg06456125 chr7:65229604 NA -0.43 -5.77 -0.33 2.18e-8 Calcium levels; CESC cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg00409905 chr10:38381863 ZNF37A -0.48 -6.39 -0.37 7.35e-10 Extrinsic epigenetic age acceleration; CESC cis rs4722166 0.532 rs6963866 chr7:22757341 C/T cg05472934 chr7:22766657 IL6 0.49 6.38 0.36 7.9e-10 Lung cancer; CESC cis rs9300255 0.722 rs11830103 chr12:123823546 A/G cg19016782 chr12:123741754 C12orf65 0.44 6.2 0.36 2.22e-9 Neutrophil percentage of white cells; CESC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg11247378 chr22:39784982 NA -0.62 -8.9 -0.48 9.2e-17 Intelligence (multi-trait analysis); CESC cis rs3092073 0.624 rs11696196 chr20:44574533 C/T cg00981651 chr20:44574847 PCIF1 0.36 5.26 0.31 2.98e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07867023 chr3:51428648 RBM15B 0.58 6.18 0.35 2.41e-9 Gut microbiome composition (summer); CESC cis rs57677839 1 rs57677839 chr11:17028189 G/A cg15084286 chr11:17036142 PLEKHA7 1.04 17.83 0.74 2.95e-47 Coronary artery disease; CESC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg03452623 chr4:187889614 NA -0.88 -15.91 -0.7 1.82e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs1018836 0.608 rs10111060 chr8:91491152 T/C cg16814680 chr8:91681699 NA -0.55 -7.66 -0.43 3.56e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg07936489 chr17:37558343 FBXL20 0.8 11.69 0.58 9.64e-26 Glomerular filtration rate (creatinine); CESC cis rs3540 0.533 rs12708585 chr15:91052285 C/T cg10434728 chr15:90938212 IQGAP1 -0.41 -7.26 -0.41 4.35e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs629535 0.773 rs489206 chr8:70064883 T/C cg21567404 chr3:27674614 NA 0.89 10.5 0.54 8.86e-22 Dupuytren's disease; CESC cis rs7208859 0.623 rs383436 chr17:28959179 A/G cg13385521 chr17:29058706 SUZ12P 0.75 5.43 0.32 1.27e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7598759 0.527 rs12987949 chr2:232367511 A/G cg19187155 chr2:232395269 NMUR1 0.61 10.12 0.53 1.43e-20 Noise-induced hearing loss; CESC cis rs1707322 1.000 rs4660334 chr1:46462126 A/C cg06784218 chr1:46089804 CCDC17 0.33 5.74 0.33 2.61e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12579753 0.719 rs4418884 chr12:82277006 C/T cg23701643 chr12:82153290 PPFIA2 -0.37 -5.4 -0.31 1.48e-7 Resting heart rate; CESC cis rs910316 1.000 rs11159117 chr14:75584867 C/T cg16144293 chr14:75469539 EIF2B2 -0.4 -5.15 -0.3 5.11e-7 Height; CESC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.4 0.41 1.75e-12 Tonsillectomy; CESC cis rs4268898 0.662 rs9784114 chr2:24437517 C/T cg08917208 chr2:24149416 ATAD2B 0.55 5.27 0.31 2.89e-7 Asthma; CESC cis rs8170 0.603 rs3810204 chr19:17448660 T/C cg04749549 chr19:17459798 NA -0.33 -5.23 -0.31 3.52e-7 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CESC trans rs10506458 0.915 rs998506 chr12:63400017 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.34 -18.35 -0.75 4.19e-49 Hemostatic factors and hematological phenotypes; CESC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -11.2 -0.57 4.22e-24 Initial pursuit acceleration; CESC cis rs10791323 0.569 rs10750541 chr11:133713189 A/C cg06766960 chr11:133703094 NA 0.38 5.17 0.3 4.52e-7 Childhood ear infection; CESC cis rs12681366 0.708 rs12680029 chr8:95404646 T/C cg13257157 chr8:95487014 RAD54B 0.39 5.21 0.3 3.82e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs965469 1.000 rs6051709 chr20:3263685 T/C cg25506879 chr20:3388711 C20orf194 -0.55 -5.98 -0.35 7.01e-9 IFN-related cytopenia; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg19630242 chr6:163987817 QKI 0.43 6.87 0.39 4.5e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs938554 0.513 rs4529048 chr4:9997112 G/T cg11266682 chr4:10021025 SLC2A9 0.46 6.96 0.39 2.6e-11 Blood metabolite levels; CESC cis rs17125944 0.505 rs75838476 chr14:53242362 G/A cg00686598 chr14:53173677 PSMC6 1.42 11.99 0.59 9.42e-27 Alzheimer's disease (late onset); CESC cis rs13343954 0.518 rs7252086 chr19:33534929 T/C cg27124370 chr19:33622961 WDR88 0.5 6.65 0.38 1.63e-10 Colorectal cancer; CESC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg09699651 chr6:150184138 LRP11 0.42 5.48 0.32 1.01e-7 Lung cancer; CESC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.4 -7.16 -0.4 8.12e-12 Bipolar disorder; CESC cis rs6866344 0.570 rs1071881 chr5:178135917 C/T cg10224037 chr5:178157518 ZNF354A 0.72 8.53 0.46 1.11e-15 Neutrophil percentage of white cells; CESC cis rs3820068 0.532 rs6701009 chr1:15935614 T/C cg16988262 chr1:15930761 NA 0.32 5.24 0.31 3.34e-7 Systolic blood pressure; CESC cis rs1348850 0.872 rs7559521 chr2:178452328 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.61 -8.16 -0.45 1.36e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09435861 chr6:110968114 CDK19 -0.59 -7.09 -0.4 1.19e-11 Gut microbiome composition (summer); CESC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg04025307 chr7:1156635 C7orf50 0.4 6.31 0.36 1.19e-9 Longevity;Endometriosis; CESC cis rs1003719 0.788 rs2835582 chr21:38458773 C/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.72 0.47 3.19e-16 Eye color traits; CESC cis rs6580649 0.941 rs4589362 chr12:48478664 T/C cg24011408 chr12:48396354 COL2A1 -0.4 -5.04 -0.3 8.67e-7 Lung cancer; CESC cis rs10911232 0.507 rs12037585 chr1:183000041 G/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs523522 0.923 rs3916065 chr12:120934624 A/C cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC trans rs931812 0.691 rs884488 chr8:101898523 C/G cg20993868 chr7:22813445 NA 0.4 5.99 0.35 6.7e-9 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs11122272 0.735 rs2790881 chr1:231534181 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs2228479 0.717 rs2074904 chr16:89811546 A/G cg00800038 chr16:89945340 TCF25 -0.9 -7.51 -0.42 9.11e-13 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04504578 chr17:36831313 C17orf96 -0.53 -6.06 -0.35 4.56e-9 Gut microbiome composition (summer); CESC cis rs9911578 0.967 rs3826353 chr17:57075299 C/T cg12560992 chr17:57184187 TRIM37 0.98 16.9 0.72 5.45e-44 Intelligence (multi-trait analysis); CESC cis rs7116495 0.529 rs575871 chr11:71778822 A/G cg10381502 chr11:71823885 C11orf51 -0.81 -6.21 -0.36 2.06e-9 Severe influenza A (H1N1) infection; CESC cis rs12477438 0.735 rs12474477 chr2:99690408 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.52 -0.54 7.38e-22 Chronic sinus infection; CESC cis rs1152591 0.562 rs1272715 chr14:64651989 A/T cg23250157 chr14:64679961 SYNE2 0.39 5.48 0.32 1e-7 Atrial fibrillation; CESC cis rs2370759 1.000 rs2225152 chr10:32574759 T/C cg01819863 chr10:32635814 EPC1 1.17 13.3 0.63 2.82e-31 Sexual dysfunction (female); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02294791 chr11:1855606 SYT8 0.34 6.05 0.35 4.96e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs644799 1.000 rs543530 chr11:95545170 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10744422 0.858 rs7980541 chr12:123379477 C/T cg25930673 chr12:123319894 HIP1R -0.66 -5.16 -0.3 4.93e-7 Schizophrenia; CESC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg24147428 chr11:65409760 SIPA1 -0.42 -5.9 -0.34 1.11e-8 Blood pressure (age interaction); CESC cis rs2625529 0.503 rs7162299 chr15:72414065 A/G cg16672083 chr15:72433130 SENP8 0.46 7.13 0.4 9.41e-12 Red blood cell count; CESC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -10.95 -0.56 2.97e-23 Extrinsic epigenetic age acceleration; CESC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg18230493 chr5:56204884 C5orf35 -0.74 -9.05 -0.49 3.27e-17 Initial pursuit acceleration; CESC trans rs2090104 0.739 rs4834203 chr4:128488553 A/G cg23537305 chr3:29355071 RBMS3 0.39 6.11 0.35 3.52e-9 IgG glycosylation; CESC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg19318889 chr4:1322082 MAEA -0.48 -6.18 -0.36 2.38e-9 Obesity-related traits; CESC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.16 0.81 2.75e-62 Prudent dietary pattern; CESC cis rs6912958 0.712 rs2307379 chr6:88366771 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.51 -6.79 -0.38 7.55e-11 Monocyte percentage of white cells; CESC cis rs3780486 0.757 rs10758189 chr9:33125804 A/G cg13443165 chr9:33130375 B4GALT1 0.44 6.29 0.36 1.29e-9 IgG glycosylation; CESC cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg03467027 chr4:99064603 C4orf37 0.48 6.05 0.35 4.87e-9 Colonoscopy-negative controls vs population controls; CESC cis rs477692 1.000 rs538969 chr10:131410608 C/T cg05714579 chr10:131428358 MGMT 0.48 6.48 0.37 4.34e-10 Response to temozolomide; CESC cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg11279151 chr3:101281821 RG9MTD1 -0.45 -5.06 -0.3 7.87e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg23048001 chr7:2026167 MAD1L1 0.46 5.93 0.34 9.5e-9 Bipolar disorder and schizophrenia; CESC cis rs1707322 0.716 rs6699444 chr1:46135120 G/C cg03146154 chr1:46216737 IPP 0.82 11.51 0.58 3.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg02297831 chr4:17616191 MED28 0.52 6.01 0.35 6.19e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg05564831 chr3:52568323 NT5DC2 0.48 7.64 0.42 4.06e-13 Bipolar disorder; CESC cis rs7894051 1.000 rs11101721 chr10:135190358 C/G cg12428399 chr10:135191333 PAOX 0.58 5.05 0.3 8.42e-7 Lifespan; CESC trans rs877282 0.898 rs11253340 chr10:764786 G/T cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg25072359 chr17:41440525 NA 0.44 5.91 0.34 1.04e-8 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01084379 chr5:179160712 MAML1 0.45 6.29 0.36 1.33e-9 Gut microbiota (bacterial taxa); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg07792822 chr1:157961914 KIRREL -0.44 -6.9 -0.39 3.71e-11 Vertical cup-disc ratio; CESC cis rs2456568 0.900 rs2456559 chr11:93668858 A/T cg26875233 chr11:93583750 C11orf90 -0.29 -5.1 -0.3 6.61e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC trans rs875971 0.929 rs778712 chr7:65849978 C/T cg26939375 chr7:64535504 NA 0.47 6.14 0.35 3.02e-9 Aortic root size; CESC cis rs3540 0.576 rs1974519 chr15:91036460 A/G cg22089800 chr15:90895588 ZNF774 0.61 8.14 0.45 1.57e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs3793683 0.571 rs12781152 chr10:134590257 G/C cg18305652 chr10:134549665 INPP5A 0.48 6.82 0.39 6.13e-11 Migraine; CESC cis rs11098499 0.909 rs79704848 chr4:120309351 T/A cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs12586317 0.531 rs60049741 chr14:35719842 G/A cg16230307 chr14:35515116 FAM177A1 0.41 5.13 0.3 5.54e-7 Psoriasis; CESC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg21782813 chr7:2030301 MAD1L1 0.44 6.13 0.35 3.23e-9 Bipolar disorder and schizophrenia; CESC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.71 0.38 1.17e-10 Bipolar disorder; CESC cis rs2963155 0.518 rs1438732 chr5:142756266 G/C cg17617527 chr5:142782415 NR3C1 0.83 7.39 0.41 1.88e-12 Breast cancer; CESC cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg02487422 chr3:49467188 NICN1 0.4 5.11 0.3 6.09e-7 Parkinson's disease; CESC cis rs12121840 0.688 rs285438 chr1:165518186 C/T cg16553119 chr1:165599451 MGST3 0.44 5.28 0.31 2.73e-7 Interleukin-1-receptor antagonist levels; CESC trans rs561341 1.000 rs560132 chr17:30320019 C/T cg20587970 chr11:113659929 NA -1.48 -19.59 -0.77 1.98e-53 Hip circumference adjusted for BMI; CESC trans rs60843830 1.000 rs62114544 chr2:269679 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.69 8.58 0.47 8.3e-16 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7927592 0.763 rs7119422 chr11:68331154 C/T cg16797656 chr11:68205561 LRP5 -0.5 -7.81 -0.43 1.31e-13 Total body bone mineral density; CESC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg19717773 chr7:2847554 GNA12 -0.45 -6.63 -0.38 1.87e-10 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06757925 chr1:70671216 LRRC40;SFRS11 0.48 6.64 0.38 1.8e-10 Gut microbiota (bacterial taxa); CESC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg08027265 chr7:2291960 NA -0.4 -6.2 -0.36 2.19e-9 Bipolar disorder and schizophrenia; CESC cis rs11792861 0.591 rs10979632 chr9:111732140 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.63 9.75 0.51 2.16e-19 Menarche (age at onset); CESC cis rs6964587 1.000 rs12333563 chr7:91667326 G/A cg17063962 chr7:91808500 NA 0.59 8.15 0.45 1.47e-14 Breast cancer; CESC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg22963979 chr7:1858916 MAD1L1 -0.38 -5.14 -0.3 5.29e-7 Bipolar disorder and schizophrenia; CESC cis rs3857067 1.000 rs1588385 chr4:95017161 A/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06051243 chr13:28024682 MTIF3 -0.64 -7.61 -0.42 4.74e-13 Gut microbiome composition (summer); CESC cis rs8018808 0.935 rs963283 chr14:77901456 C/A cg20045696 chr14:77926864 AHSA1 0.42 5.79 0.33 2.04e-8 Myeloid white cell count; CESC cis rs1008375 0.931 rs6837181 chr4:17701253 A/C cg02297831 chr4:17616191 MED28 0.49 5.91 0.34 1.03e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11718455 0.767 rs11130019 chr3:43989348 C/A cg08738300 chr3:44038990 NA 0.45 5.93 0.34 9.54e-9 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02399652 chr3:169684620 LOC100128164;SEC62 0.47 6.18 0.35 2.42e-9 Gut microbiota (bacterial taxa); CESC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg26516362 chr5:178986906 RUFY1 0.39 5.82 0.34 1.66e-8 Lung cancer; CESC cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg10556349 chr10:835070 NA 0.56 5.41 0.32 1.4e-7 Eosinophil percentage of granulocytes; CESC cis rs9929218 0.953 rs3118235 chr16:68732977 A/G cg02972257 chr16:68554789 NA -0.46 -5.2 -0.3 4.05e-7 Colorectal cancer; CESC cis rs4906332 1.000 rs12889703 chr14:103872951 T/A cg09975044 chr14:104007538 NA 0.46 6.24 0.36 1.74e-9 Coronary artery disease; CESC cis rs4237845 0.715 rs4760340 chr12:58275176 A/T cg02175503 chr12:58329896 NA 0.51 6.59 0.38 2.3e-10 Intelligence (multi-trait analysis); CESC cis rs10129255 0.509 rs756583 chr14:107136019 C/T cg07958169 chr14:107095056 NA -0.46 -6.89 -0.39 4.09e-11 Kawasaki disease; CESC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.56 7.09 0.4 1.18e-11 Height; CESC cis rs1558375 0.679 rs31674 chr7:87068464 T/C cg00919237 chr7:87102261 ABCB4 0.39 5.39 0.31 1.53e-7 Gallbladder cancer; CESC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg02187348 chr16:89574699 SPG7 0.61 8.55 0.47 9.9e-16 Multiple myeloma (IgH translocation); CESC cis rs6430585 0.697 rs6724569 chr2:136516970 G/A cg07169764 chr2:136633963 MCM6 1.26 16.59 0.71 7.22e-43 Corneal structure; CESC cis rs6088580 0.634 rs2225837 chr20:33005634 C/T cg24642439 chr20:33292090 TP53INP2 -0.53 -6.99 -0.39 2.17e-11 Glomerular filtration rate (creatinine); CESC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.98 0.34 7.35e-9 Tonsillectomy; CESC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg27125505 chr17:43679177 LOC644172 -0.5 -7.24 -0.41 4.79e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21354621 chr12:46384284 SFRS2IP 0.5 6.42 0.37 6.35e-10 Gut microbiota (bacterial taxa); CESC cis rs2228479 0.850 rs62054611 chr16:89817017 T/C cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.73 9.86 0.52 9.76e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs365060 0.542 rs5021634 chr2:109582357 A/G cg03398303 chr18:12702742 PSMG2;CEP76 -0.56 -6.1 -0.35 3.74e-9 Beard thickness; CESC cis rs875971 0.658 rs432667 chr7:65514633 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.49 -0.32 9.58e-8 Aortic root size; CESC cis rs6459804 0.588 rs78762416 chr7:157511142 G/A cg05731713 chr7:157510257 PTPRN2 0.38 5.22 0.31 3.67e-7 Bipolar disorder and schizophrenia; CESC cis rs9905704 0.918 rs654743 chr17:56736490 T/C cg12560992 chr17:57184187 TRIM37 0.59 6.98 0.39 2.34e-11 Testicular germ cell tumor; CESC cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg01181863 chr3:195395398 SDHAP2 -0.5 -5.85 -0.34 1.47e-8 Pancreatic cancer; CESC cis rs854765 0.583 rs4414547 chr17:17859052 G/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg27121462 chr16:89883253 FANCA 0.73 10.57 0.54 5.03e-22 Vitiligo; CESC cis rs4242434 0.927 rs13264187 chr8:22506098 C/T cg03733263 chr8:22462867 KIAA1967 0.93 14.29 0.66 9.47e-35 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs12579753 0.719 rs11115060 chr12:82269624 C/T cg23701643 chr12:82153290 PPFIA2 -0.36 -5.29 -0.31 2.57e-7 Resting heart rate; CESC cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg19193384 chr17:30244184 NA -0.7 -6.34 -0.36 9.87e-10 Hip circumference adjusted for BMI; CESC cis rs9322193 0.886 rs9767555 chr6:149968158 T/C cg04369109 chr6:150039330 LATS1 -0.37 -5.12 -0.3 5.82e-7 Lung cancer; CESC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg08392591 chr16:89556376 ANKRD11 0.61 8.38 0.46 3.2e-15 Multiple myeloma (IgH translocation); CESC cis rs1570884 0.516 rs9316463 chr13:50176844 G/A cg08779649 chr13:50194554 NA 0.39 6.7 0.38 1.25e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.57 0.37 2.58e-10 Bipolar disorder; CESC cis rs116979167 0.630 rs56230603 chr7:105165268 A/G cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs4746818 0.793 rs2008553 chr10:70860475 C/G cg11621586 chr10:70884670 VPS26A 0.77 9.07 0.49 2.66e-17 Left atrial antero-posterior diameter; CESC cis rs28647808 1.000 rs28504382 chr9:136275674 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs17826219 0.568 rs2626985 chr17:29077437 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Body mass index; CESC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg02725872 chr8:58115012 NA -0.45 -6.84 -0.39 5.31e-11 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14774511 chr12:3371886 TSPAN9 -0.5 -6.05 -0.35 5.03e-9 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg23281280 chr6:28129359 ZNF389 0.6 8.13 0.45 1.68e-14 Depression; CESC cis rs950776 0.593 rs601079 chr15:78869579 T/A cg06917634 chr15:78832804 PSMA4 -0.59 -7.85 -0.43 1.01e-13 Sudden cardiac arrest; CESC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg01988459 chr11:68622903 NA -0.41 -5.44 -0.32 1.23e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9614461 0.609 rs9614653 chr22:45767391 A/G cg15911859 chr22:45810043 RIBC2;SMC1B -0.66 -7.54 -0.42 7.43e-13 Tonsillectomy; CESC cis rs10751667 0.643 rs10794343 chr11:925493 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.26 -0.31 2.98e-7 Alzheimer's disease (late onset); CESC cis rs2985684 1.000 rs1957977 chr14:50090603 A/G cg02151108 chr14:50098012 C14orf104 -0.45 -5.79 -0.34 1.98e-8 Carotid intima media thickness; CESC cis rs17253792 0.545 rs12883972 chr14:56018020 A/G cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.71 11.44 0.57 6.9e-25 Personality dimensions; CESC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs55794721 0.509 rs6699896 chr1:25762902 A/T cg02931644 chr1:25747376 RHCE 0.47 8.04 0.44 3.09e-14 Plateletcrit;Mean corpuscular volume; CESC cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg25358565 chr5:93447407 FAM172A 1.01 10.46 0.54 1.16e-21 Diabetic retinopathy; CESC cis rs6500602 0.855 rs1139652 chr16:4476089 T/C cg08645402 chr16:4508243 NA 0.37 5.25 0.31 3.07e-7 Schizophrenia; CESC cis rs17750015 0.733 rs12454365 chr18:54396215 G/A cg18434998 chr18:54306185 TXNL1 -0.44 -5.65 -0.33 4.12e-8 Depression and alcohol dependence; CESC trans rs1814175 0.630 rs1722019 chr11:49904102 G/A cg15704280 chr7:45808275 SEPT13 -0.81 -11.22 -0.57 3.66e-24 Height; CESC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg15052019 chr19:19431593 KIAA0892;SF4 -0.42 -5.31 -0.31 2.38e-7 Tonsillectomy; CESC cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg05729581 chr11:3078854 CARS 0.4 5.45 0.32 1.14e-7 Longevity; CESC cis rs7605827 0.897 rs2178238 chr2:15533520 C/T cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs660498 0.507 rs11015783 chr10:27729745 A/G cg08398567 chr10:27609333 NA 0.38 5.17 0.3 4.72e-7 Asthma (childhood onset); CESC cis rs1348850 0.793 rs12990917 chr2:178487259 T/G cg23306229 chr2:178417860 TTC30B 0.56 7.25 0.41 4.62e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7224668 0.647 rs8070549 chr17:79247099 A/G cg05632623 chr17:78450055 NPTX1 -0.29 -5.11 -0.3 6.07e-7 IgG glycosylation; CESC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg06221963 chr1:154839813 KCNN3 -0.5 -7.45 -0.42 1.34e-12 Prostate cancer; CESC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.663 rs1052299 chr17:17750419 A/G cg04398451 chr17:18023971 MYO15A 0.64 9.33 0.5 4.27e-18 Total body bone mineral density; CESC cis rs2637266 0.935 rs2252652 chr10:78405022 C/T cg18941641 chr10:78392320 NA 0.43 8.31 0.45 4.93e-15 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12368702 chr16:53165711 CHD9 0.55 6.11 0.35 3.62e-9 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs5750630 chr22:38985818 A/C cg14440974 chr22:39074834 NA -0.4 -5.23 -0.31 3.43e-7 Menopause (age at onset); CESC cis rs36051895 0.623 rs10118434 chr9:5238460 A/G cg02405213 chr9:5042618 JAK2 -0.54 -6.57 -0.37 2.6e-10 Pediatric autoimmune diseases; CESC cis rs854765 0.565 rs854768 chr17:18018806 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.42 0.46 2.45e-15 Total body bone mineral density; CESC cis rs9309473 0.950 rs13408433 chr2:73883072 G/A cg20560298 chr2:73613845 ALMS1 -0.53 -6.77 -0.38 8.13e-11 Metabolite levels; CESC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg03467027 chr4:99064603 C4orf37 0.49 6.23 0.36 1.82e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4268898 0.610 rs72791170 chr2:24449776 C/T cg08917208 chr2:24149416 ATAD2B 0.53 5.24 0.31 3.2e-7 Asthma; CESC cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.01 0.62 2.85e-30 Hip circumference adjusted for BMI; CESC cis rs11785693 0.909 rs62489557 chr8:4968371 A/G cg26367366 chr8:4980734 NA 0.86 7.35 0.41 2.48e-12 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs7116495 0.609 rs7126394 chr11:71685429 A/G cg07596299 chr11:71824057 C11orf51 -0.83 -5.39 -0.31 1.58e-7 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05129610 chr7:23053937 FAM126A -0.58 -7.45 -0.42 1.33e-12 Gut microbiome composition (summer); CESC trans rs7246760 0.867 rs73011937 chr19:9832530 T/C cg02900749 chr2:68251473 NA -0.8 -7.31 -0.41 3.22e-12 Pursuit maintenance gain; CESC cis rs7524258 0.868 rs4243824 chr1:7289777 G/A cg07173049 chr1:7289937 CAMTA1 0.47 6.96 0.39 2.59e-11 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs950776 0.722 rs471889 chr15:78870235 T/C cg06917634 chr15:78832804 PSMA4 -0.5 -6.19 -0.36 2.26e-9 Sudden cardiac arrest; CESC cis rs362272 0.524 rs7435601 chr4:3369645 A/G cg08886695 chr4:3369023 RGS12 -0.39 -5.41 -0.32 1.38e-7 Serum sulfate level; CESC cis rs2735413 0.875 rs12925138 chr16:78083923 C/T cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs698833 0.852 rs4953092 chr2:44565293 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 6.54 0.37 3.2e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs6942756 0.876 rs1559486 chr7:129015894 C/T cg02491457 chr7:128862824 NA -0.58 -8.11 -0.45 1.92e-14 White matter hyperintensity burden; CESC cis rs752010 1.000 rs752010 chr1:42093015 C/T cg06885757 chr1:42089581 HIVEP3 0.49 8.08 0.44 2.28e-14 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07954941 chr9:132176642 NA -0.51 -6.0 -0.35 6.4e-9 Gut microbiome composition (summer); CESC cis rs2479724 0.870 rs6902650 chr6:41764080 G/A cg17623882 chr6:41773611 USP49 0.41 5.74 0.33 2.52e-8 Menarche (age at onset); CESC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg07701084 chr6:150067640 NUP43 0.43 6.0 0.35 6.52e-9 Lung cancer; CESC cis rs7937682 0.632 rs11214015 chr11:111719417 A/T cg09085632 chr11:111637200 PPP2R1B -0.85 -10.9 -0.56 4.27e-23 Primary sclerosing cholangitis; CESC cis rs9858542 0.953 rs12330269 chr3:49513910 G/A cg07274523 chr3:49395745 GPX1 0.66 8.05 0.44 2.78e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs2207136 0.835 rs2143881 chr6:50852887 C/A cg06522515 chr3:184090630 THPO -0.36 -6.24 -0.36 1.69e-9 Myopia; CESC cis rs6714710 0.603 rs11123974 chr2:98605982 A/G cg26665480 chr2:98280029 ACTR1B 0.51 7.12 0.4 9.97e-12 Posterior cortical atrophy and Alzheimer's disease; CESC trans rs8073060 0.586 rs7221203 chr17:34015532 T/C cg19694781 chr19:47549865 TMEM160 -0.71 -6.74 -0.38 9.95e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg01988459 chr11:68622903 NA -0.45 -5.89 -0.34 1.15e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg00436174 chr2:128051630 ERCC3 0.45 6.12 0.35 3.42e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs8111998 0.826 rs10420648 chr19:22767819 G/A cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10173240 chr14:90849342 NA -0.42 -6.05 -0.35 4.87e-9 Gambling; CESC trans rs459571 0.959 rs456205 chr9:136911146 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.67 -8.79 -0.48 1.98e-16 Platelet distribution width; CESC cis rs7666738 0.830 rs62318471 chr4:98925848 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg26597838 chr10:835615 NA 0.76 7.15 0.4 8.67e-12 Eosinophil percentage of granulocytes; CESC cis rs2562152 0.786 rs216594 chr16:103009 A/T cg02949481 chr16:131562 MPG 0.54 5.8 0.34 1.91e-8 Glioblastoma; CESC cis rs1476670 0.710 rs2485993 chr1:44503040 C/T cg09470012 chr1:44509516 NA -0.32 -5.14 -0.3 5.45e-7 Eotaxin levels; CESC cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7412746 0.634 rs4451553 chr1:150937329 C/T cg17724175 chr1:150552817 MCL1 0.39 5.92 0.34 1e-8 Melanoma; CESC cis rs1355223 0.752 rs17293467 chr11:34677360 C/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.11 -0.35 3.49e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs4820539 1.000 rs6003518 chr22:23471533 C/T cg14186256 chr22:23484241 RTDR1 0.82 14.65 0.67 5.33e-36 Bone mineral density; CESC cis rs7927771 0.524 rs11039402 chr11:47826090 A/C cg18512352 chr11:47633146 NA 0.35 5.33 0.31 2.05e-7 Subjective well-being; CESC cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg11752832 chr7:134001865 SLC35B4 0.52 6.77 0.38 8.06e-11 Mean platelet volume; CESC cis rs3747547 0.818 rs7023756 chr9:37946629 A/G cg13774184 chr9:37916125 SHB -0.59 -6.06 -0.35 4.57e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg24846343 chr22:24311635 DDTL 0.47 7.71 0.43 2.57e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9399135 0.967 rs6902954 chr6:135313994 C/A cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs9291683 0.546 rs13110307 chr4:10044364 T/C cg11266682 chr4:10021025 SLC2A9 0.65 12.28 0.6 9.55e-28 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20919922 chr2:75185588 POLE4 0.55 6.07 0.35 4.44e-9 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs1061346 chr17:29114229 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3087591 0.960 rs12943508 chr17:29599954 C/G cg24425628 chr17:29625626 OMG;NF1 0.46 5.73 0.33 2.79e-8 Hip circumference; CESC cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg25019033 chr10:957182 NA -0.56 -6.04 -0.35 5.1e-9 Eosinophil percentage of granulocytes; CESC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.32 0.31 2.18e-7 Tonsillectomy; CESC cis rs6723226 0.598 rs2710629 chr2:32765844 C/T cg02381751 chr2:32503542 YIPF4 0.49 6.43 0.37 6.07e-10 Intelligence (multi-trait analysis); CESC cis rs11098499 0.775 rs10029303 chr4:120286755 T/A cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs1784581 0.588 rs7765624 chr6:162427462 C/A cg17173639 chr6:162384350 PARK2 0.57 8.58 0.47 7.87e-16 Itch intensity from mosquito bite; CESC cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg22467129 chr15:76604101 ETFA -0.39 -6.26 -0.36 1.52e-9 Blood metabolite levels; CESC cis rs4604732 0.631 rs12080860 chr1:247623053 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.55 7.01 0.4 1.92e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs963731 0.649 rs297135 chr2:39304793 G/A cg04010122 chr2:39346883 SOS1 -0.76 -5.74 -0.33 2.65e-8 Corticobasal degeneration; CESC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg09177884 chr7:1199841 ZFAND2A -0.5 -6.28 -0.36 1.35e-9 Longevity;Endometriosis; CESC cis rs6088590 0.542 rs6059956 chr20:33220070 A/G cg08999081 chr20:33150536 PIGU 0.68 11.6 0.58 1.92e-25 Coronary artery disease; CESC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg18230493 chr5:56204884 C5orf35 -0.61 -8.34 -0.46 4.24e-15 Initial pursuit acceleration; CESC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg18305652 chr10:134549665 INPP5A 0.45 6.26 0.36 1.53e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs561341 0.941 rs550213 chr17:30317518 C/G cg12193833 chr17:30244370 NA -0.58 -5.96 -0.34 7.88e-9 Hip circumference adjusted for BMI; CESC cis rs12893668 0.703 rs4906338 chr14:104050357 A/G cg08213375 chr14:104286397 PPP1R13B 0.33 5.12 0.3 5.83e-7 Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10798048 chr1:16399867 FAM131C 0.52 6.14 0.35 2.95e-9 Gut microbiome composition (summer); CESC cis rs287982 1.000 rs13404815 chr2:9967766 A/G cg10881225 chr2:9984929 TAF1B 0.4 5.16 0.3 4.94e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs11734570 0.581 rs75356782 chr4:38600053 T/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.61 7.42 0.41 1.56e-12 Inflammatory bowel disease;Crohn's disease; CESC trans rs6951245 0.744 rs10265736 chr7:1172465 C/T cg13565492 chr6:43139072 SRF -0.61 -6.32 -0.36 1.1e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg17158414 chr2:27665306 KRTCAP3 -0.29 -5.22 -0.31 3.58e-7 Total body bone mineral density; CESC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg26335602 chr6:28129616 ZNF389 0.48 6.14 0.35 3.05e-9 Parkinson's disease; CESC cis rs116095464 0.558 rs3213838 chr5:223890 G/C cg10591111 chr5:226296 SDHA -0.52 -6.52 -0.37 3.47e-10 Breast cancer; CESC cis rs2072732 0.861 rs72629494 chr1:2951349 T/C cg15211996 chr1:2936768 ACTRT2 0.34 5.95 0.34 8.31e-9 Plateletcrit; CESC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg08736216 chr1:53307985 ZYG11A 0.3 5.07 0.3 7.55e-7 Monocyte count; CESC cis rs290268 0.838 rs1333635 chr9:93566406 A/G cg02608019 chr9:93564028 SYK 0.68 10.27 0.53 4.93e-21 Platelet count; CESC cis rs76025697 1 rs76025697 chr5:179184488 G/A cg14593053 chr5:179126677 CANX 0.41 5.39 0.31 1.55e-7 Granulocyte percentage of myeloid white cells;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Granulocyte count; CESC cis rs4891159 0.548 rs690423 chr18:74117984 G/A cg24786174 chr18:74118243 ZNF516 0.85 15.89 0.7 2.23e-40 Longevity; CESC cis rs12893597 0.715 rs34486942 chr14:76831530 G/A cg20290672 chr14:76816747 NA -0.4 -5.64 -0.33 4.31e-8 Maximal oxygen uptake response; CESC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg17971929 chr21:40555470 PSMG1 -0.6 -7.92 -0.44 6.45e-14 Menarche (age at onset); CESC cis rs4629180 0.701 rs10202801 chr2:102106670 T/C cg04415270 chr2:102091202 RFX8 -0.31 -5.39 -0.31 1.53e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg08917208 chr2:24149416 ATAD2B 0.67 6.42 0.37 6.2e-10 Lymphocyte counts; CESC cis rs1055129 0.560 rs2305913 chr17:73922941 T/C cg08125733 chr17:73851984 WBP2 0.52 7.15 0.4 8.32e-12 White matter hyperintensity burden; CESC cis rs258892 0.895 rs34252662 chr5:72054308 G/C cg21869765 chr5:72125136 TNPO1 -0.43 -5.36 -0.31 1.8e-7 Small cell lung carcinoma; CESC cis rs3815700 1.000 rs7248273 chr19:33096816 C/T cg24916020 chr19:33096688 ANKRD27 0.59 5.79 0.33 2.01e-8 Eosinophilic esophagitis; CESC cis rs425277 1.000 rs196128 chr1:2078444 T/G cg04315214 chr1:2043799 PRKCZ -0.38 -5.3 -0.31 2.42e-7 Height; CESC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg07952391 chr2:88470173 THNSL2 -0.54 -8.13 -0.45 1.61e-14 Response to metformin (IC50); CESC cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg17366294 chr4:99064904 C4orf37 0.55 7.47 0.42 1.15e-12 Colonoscopy-negative controls vs population controls; CESC cis rs870825 0.860 rs72703529 chr4:185607351 T/C cg04058563 chr4:185651563 MLF1IP 0.54 5.24 0.31 3.27e-7 Blood protein levels; CESC cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg02487422 chr3:49467188 NICN1 0.43 5.48 0.32 9.87e-8 Parkinson's disease; CESC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.69 -8.57 -0.47 8.51e-16 Alzheimer's disease; CESC cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs10779751 1.000 rs7549109 chr1:11278813 C/G cg08854313 chr1:11322531 MTOR -0.93 -14.42 -0.66 3.33e-35 Body mass index; CESC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC cis rs7824557 0.603 rs6995404 chr8:11182148 C/G cg21775007 chr8:11205619 TDH 0.46 7.13 0.4 9.66e-12 Retinal vascular caliber; CESC cis rs2228479 0.850 rs11649162 chr16:89807131 C/A cg00800038 chr16:89945340 TCF25 -0.89 -7.39 -0.41 1.95e-12 Skin colour saturation; CESC cis rs634534 0.561 rs613924 chr11:65769295 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.84 0.39 5.62e-11 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs2559856 1.000 rs2695282 chr12:102089502 A/G cg15068132 chr12:102092402 CHPT1 0.42 5.52 0.32 7.97e-8 Blood protein levels; CESC cis rs17818399 0.926 rs35682608 chr2:46836542 A/T cg02822958 chr2:46747628 ATP6V1E2 0.47 5.64 0.33 4.45e-8 Height; CESC cis rs7216064 1.000 rs34872586 chr17:65863466 T/C cg12091567 chr17:66097778 LOC651250 -0.85 -8.7 -0.47 3.61e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs17209837 1.000 rs2072383 chr7:87081349 A/G cg00919237 chr7:87102261 ABCB4 -0.53 -6.11 -0.35 3.63e-9 Gallbladder cancer; CESC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg03647317 chr4:187891568 NA 0.39 5.75 0.33 2.5e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs2070433 0.539 rs1008548 chr21:47959692 G/A cg12379764 chr21:47803548 PCNT 0.63 8.17 0.45 1.26e-14 Lymphocyte counts; CESC cis rs6662572 0.901 rs28484896 chr1:46184200 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 5.49 0.32 9.48e-8 Blood protein levels; CESC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg00802000 chr16:706648 WDR90 -0.43 -6.57 -0.37 2.64e-10 Height; CESC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg07677032 chr17:61819896 STRADA 0.46 6.12 0.35 3.31e-9 Prudent dietary pattern; CESC cis rs672059 1.000 rs480132 chr1:183161779 A/G ch.1.3577855R chr1:183094577 LAMC1 0.54 7.05 0.4 1.59e-11 Hypertriglyceridemia; CESC cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg20503657 chr10:835505 NA 0.78 7.74 0.43 2.14e-13 Eosinophil percentage of granulocytes; CESC cis rs9399135 0.967 rs6925424 chr6:135313948 T/A cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs7310409 0.544 rs1169292 chr12:121426478 C/T cg25281562 chr12:121454272 C12orf43 0.57 7.06 0.4 1.47e-11 Liver enzyme levels (gamma-glutamyl transferase);C-reactive protein;Pancreatic cancer; CESC cis rs6540556 0.517 rs1474655 chr1:209884730 G/C cg05527609 chr1:210001259 C1orf107 -0.73 -7.15 -0.4 8.66e-12 Red blood cell count; CESC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg11663144 chr21:46675770 NA -0.51 -7.07 -0.4 1.4e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7264396 0.563 rs2425137 chr20:34345396 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -9.16 -0.49 1.5e-17 Total cholesterol levels; CESC cis rs10979 1.000 rs9484769 chr6:143896719 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs3820068 0.705 rs7533125 chr1:15883744 T/C cg18192808 chr1:15853278 DNAJC16 0.43 5.17 0.3 4.6e-7 Systolic blood pressure; CESC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg04944784 chr2:26401820 FAM59B -0.8 -8.93 -0.48 7.17e-17 Gut microbiome composition (summer); CESC cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg17143192 chr8:8559678 CLDN23 0.78 8.81 0.48 1.63e-16 Obesity-related traits; CESC cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg05347473 chr6:146136440 FBXO30 0.55 7.1 0.4 1.16e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.33 0.31 2.11e-7 Personality dimensions; CESC cis rs561341 1.000 rs537166 chr17:30326827 C/T cg12193833 chr17:30244370 NA -0.59 -5.92 -0.34 9.93e-9 Hip circumference adjusted for BMI; CESC cis rs116095464 0.558 rs62344300 chr5:246336 A/G cg22857025 chr5:266934 NA -1.27 -18.37 -0.75 3.49e-49 Breast cancer; CESC trans rs561341 0.714 rs55925849 chr17:30253085 C/T cg27661571 chr11:113659931 NA -0.87 -7.9 -0.44 7.5e-14 Hip circumference adjusted for BMI; CESC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg04267008 chr7:1944627 MAD1L1 -0.71 -9.09 -0.49 2.4e-17 Bipolar disorder and schizophrenia; CESC cis rs9287719 0.901 rs13034017 chr2:10739592 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg20307385 chr11:47447363 PSMC3 -0.63 -7.6 -0.42 5.12e-13 Subjective well-being; CESC cis rs2569991 0.636 rs2600222 chr3:12937617 C/G cg22481960 chr3:13008800 IQSEC1 -0.56 -6.6 -0.38 2.26e-10 Periodontitis (DPAL); CESC cis rs918629 0.761 rs3777165 chr5:95291425 A/G cg16656078 chr5:95278638 ELL2 0.39 5.13 0.3 5.68e-7 IgG glycosylation; CESC cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg13880726 chr7:1868755 MAD1L1 -0.48 -5.08 -0.3 7.23e-7 Bipolar disorder; CESC cis rs829883 0.872 rs1641637 chr12:98890564 G/A cg25150519 chr12:98850993 NA 0.7 9.64 0.51 4.82e-19 Colorectal adenoma (advanced); CESC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg09165964 chr15:75287851 SCAMP5 0.47 6.65 0.38 1.68e-10 Breast cancer; CESC cis rs6696846 0.905 rs11240349 chr1:205041015 G/A cg00857998 chr1:205179979 DSTYK 0.55 7.13 0.4 9.68e-12 Red blood cell count; CESC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg27165867 chr14:105738592 BRF1 -0.48 -5.42 -0.32 1.32e-7 Mean platelet volume;Platelet distribution width; CESC cis rs3862030 0.500 rs11191327 chr10:104303883 T/C cg22532475 chr10:104410764 TRIM8 -0.33 -5.69 -0.33 3.3e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg01579765 chr21:45077557 HSF2BP -0.56 -9.51 -0.5 1.24e-18 Mean corpuscular volume; CESC cis rs1707322 0.656 rs3014210 chr1:46066608 A/G cg03146154 chr1:46216737 IPP -0.73 -9.89 -0.52 7.72e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23200371 chr12:56367680 RAB5B -0.47 -6.14 -0.35 3.03e-9 Fibrinogen levels; CESC cis rs4891159 0.790 rs660029 chr18:74149668 A/G cg24786174 chr18:74118243 ZNF516 0.77 12.55 0.61 1.19e-28 Longevity; CESC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4604732 0.578 rs79203328 chr1:247626581 C/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Tonsillectomy; CESC cis rs3126085 0.935 rs4845429 chr1:152225376 G/C cg03465714 chr1:152285911 FLG -0.42 -5.35 -0.31 1.93e-7 Atopic dermatitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06913508 chr2:207630136 FASTKD2;MDH1B 0.61 7.1 0.4 1.16e-11 Gut microbiome composition (summer); CESC cis rs7429990 0.932 rs810334 chr3:47935303 G/T cg11946769 chr3:48343235 NME6 0.42 5.11 0.3 6.05e-7 Educational attainment (years of education); CESC cis rs11098499 0.657 rs7664458 chr4:120371967 A/G cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs8002861 0.967 rs7994883 chr13:44478805 A/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.41 -5.34 -0.31 1.99e-7 Leprosy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17157516 chr1:35332203 DLGAP3 -0.42 -6.26 -0.36 1.59e-9 Gambling; CESC cis rs7714584 1.000 rs11955172 chr5:150254378 T/C cg22134413 chr5:150180641 NA 0.51 5.92 0.34 9.88e-9 Crohn's disease; CESC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg18099408 chr3:52552593 STAB1 -0.32 -5.31 -0.31 2.35e-7 Bipolar disorder; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg25940730 chr4:16228647 TAPT1;FLJ39653 0.46 6.08 0.35 4.12e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2425143 0.908 rs74784474 chr20:34422464 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.17 -0.4 7.71e-12 Blood protein levels; CESC cis rs6752107 1.000 rs34123137 chr2:234167881 T/A cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.4 6.04 0.35 5.16e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg18230493 chr5:56204884 C5orf35 -0.58 -7.57 -0.42 6.2800000000000005e-13 Coronary artery disease; CESC cis rs6963495 0.818 rs9769403 chr7:105163091 G/A cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs9287719 0.967 rs6733416 chr2:10738684 C/T cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg05343316 chr1:45956843 TESK2 -0.51 -6.5 -0.37 3.93e-10 High light scatter reticulocyte count; CESC cis rs116095464 0.558 rs9654452 chr5:299561 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.17 0.3 4.68e-7 Breast cancer; CESC cis rs1986734 0.576 rs2068062 chr4:77417214 A/C cg20311846 chr4:77356250 SHROOM3 -0.28 -5.68 -0.33 3.55e-8 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC cis rs2276314 0.793 rs77590522 chr18:33629410 C/G cg19628046 chr18:33552617 C18orf21 0.52 5.57 0.32 6.4e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs10465746 0.935 rs1871925 chr1:84464468 C/G cg10977910 chr1:84465055 TTLL7 0.48 6.4 0.37 6.99e-10 Obesity-related traits; CESC cis rs1790761 0.505 rs4320958 chr11:67310334 G/A cg00290607 chr11:67383545 NA -0.37 -5.39 -0.31 1.54e-7 Mean corpuscular volume; CESC cis rs2295499 0.744 rs2282768 chr4:2716147 A/C cg27239842 chr4:2403781 ZFYVE28 -0.33 -5.57 -0.32 6.26e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs57506017 0.585 rs2302633 chr7:12270815 C/T cg23422036 chr7:12250390 TMEM106B 0.39 5.17 0.3 4.57e-7 Neuroticism; CESC cis rs1059312 0.932 rs4760589 chr12:129284382 T/C cg09035930 chr12:129282057 SLC15A4 0.75 10.74 0.55 1.41e-22 Systemic lupus erythematosus; CESC cis rs2070488 0.766 rs4679050 chr3:38482007 G/A cg24069376 chr3:38537580 EXOG 0.35 5.99 0.35 6.93e-9 Electrocardiographic conduction measures; CESC cis rs9911578 0.692 rs411988 chr17:56709034 G/A cg12560992 chr17:57184187 TRIM37 0.83 12.95 0.62 4.96e-30 Intelligence (multi-trait analysis); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00373665 chr1:234735703 NA 0.47 6.1 0.35 3.66e-9 Systemic lupus erythematosus; CESC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg20243544 chr17:37824526 PNMT -0.48 -6.07 -0.35 4.42e-9 Glomerular filtration rate (creatinine); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16676734 chr14:93582668 ITPK1 -0.46 -6.2 -0.36 2.16e-9 Asthma; CESC cis rs12410462 1.000 rs75637482 chr1:227622944 A/T cg23173402 chr1:227635558 NA 0.57 5.92 0.34 9.9e-9 Major depressive disorder; CESC cis rs9929218 0.520 rs1078621 chr16:68778996 C/T cg02972257 chr16:68554789 NA -0.42 -5.25 -0.31 3.07e-7 Colorectal cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02984193 chr15:91260561 BLM -0.38 -6.04 -0.35 5.31e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09485063 chr2:75107440 HK2 -0.59 -6.84 -0.39 5.49e-11 Gut microbiome composition (summer); CESC cis rs1023500 0.551 rs2301521 chr22:42423110 G/C cg04733989 chr22:42467013 NAGA 0.8 11.11 0.56 8.81e-24 Schizophrenia; CESC trans rs7922314 0.571 rs61865718 chr10:64740407 C/A cg06935979 chr1:232941706 KIAA1383 -0.63 -6.19 -0.36 2.23e-9 Cutaneous psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10700647 chr1:28832638 SNHG3-RCC1;SNHG3 -0.52 -6.2 -0.36 2.16e-9 Gut microbiome composition (summer); CESC cis rs2050392 1.000 rs2253585 chr10:30696503 C/T cg18806716 chr10:30721971 MAP3K8 -0.42 -6.16 -0.35 2.62e-9 Inflammatory bowel disease; CESC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg17376030 chr22:41985996 PMM1 0.72 7.8 0.43 1.43e-13 Vitiligo; CESC cis rs3204270 0.639 rs7216239 chr17:79660187 C/T cg26965718 chr17:79658957 HGS -0.78 -5.6 -0.33 5.27e-8 Dental caries; CESC cis rs7959452 0.535 rs4761228 chr12:69682327 G/A cg14784868 chr12:69753453 YEATS4 0.72 10.15 0.53 1.15e-20 Blood protein levels; CESC cis rs9443645 0.869 rs6913028 chr6:79513590 C/T cg05283184 chr6:79620031 NA -0.43 -6.71 -0.38 1.19e-10 Intelligence (multi-trait analysis); CESC cis rs28374715 0.578 rs7169543 chr15:41620405 T/C cg18705301 chr15:41695430 NDUFAF1 -1.05 -15.34 -0.69 1.9e-38 Ulcerative colitis; CESC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.49 -0.5 1.38e-18 Alzheimer's disease; CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg10150615 chr22:24372951 LOC391322 -0.55 -7.35 -0.41 2.42e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23113715 chr22:25800663 NA 0.55 6.54 0.37 3.17e-10 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs7794661 chr7:65389730 T/C cg25894440 chr7:65020034 NA -0.6 -5.16 -0.3 4.78e-7 Diabetic kidney disease; CESC trans rs561341 0.883 rs7406056 chr17:30220224 C/T cg20587970 chr11:113659929 NA -1.03 -12.68 -0.61 4.19e-29 Hip circumference adjusted for BMI; CESC cis rs12887734 0.524 rs722637 chr14:104261723 G/T cg08213375 chr14:104286397 PPP1R13B -0.39 -6.78 -0.38 7.94e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC trans rs2154294 0.625 rs10151297 chr14:42649081 C/T cg07368857 chr3:71276336 FOXP1 -0.33 -6.21 -0.36 1.99e-9 Alcoholism (12-month weekly alcohol consumption); CESC cis rs1983891 0.874 rs2395779 chr6:41511950 C/T cg20194872 chr6:41519635 FOXP4 0.52 7.45 0.42 1.29e-12 Prostate cancer; CESC cis rs2404602 0.647 rs10851889 chr15:77023336 C/T cg23625390 chr15:77176239 SCAPER -0.46 -6.5 -0.37 4.05e-10 Blood metabolite levels; CESC cis rs7216064 1.000 rs4569324 chr17:65872750 C/T cg07042672 chr17:66097459 LOC651250 -0.53 -5.47 -0.32 1.04e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs12681366 0.663 rs10216902 chr8:95479978 A/G cg13257157 chr8:95487014 RAD54B 0.39 5.41 0.32 1.44e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs7246760 0.867 rs12462694 chr19:9778032 C/T cg02900749 chr2:68251473 NA -0.84 -7.5 -0.42 9.88e-13 Pursuit maintenance gain; CESC cis rs7923609 1.000 rs4399232 chr10:64999490 C/T cg01631684 chr10:65280961 REEP3 -0.45 -5.56 -0.32 6.57e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.49 -6.61 -0.38 2.05e-10 Personality dimensions; CESC cis rs6582630 0.502 rs7311700 chr12:38463232 T/A cg26384229 chr12:38710491 ALG10B 0.72 10.64 0.55 3.12e-22 Drug-induced liver injury (flucloxacillin); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03442064 chr6:41515050 FOXP4 0.51 6.93 0.39 3.19e-11 Gut microbiota (bacterial taxa); CESC cis rs34638657 0.732 rs12597010 chr16:82199971 G/A cg09439754 chr16:82129088 HSD17B2 -0.37 -6.42 -0.37 6.31e-10 Lung adenocarcinoma; CESC cis rs3820068 0.705 rs4646083 chr1:15825564 G/A cg17385448 chr1:15911702 AGMAT 0.4 6.12 0.35 3.37e-9 Systolic blood pressure; CESC trans rs3942852 0.806 rs1875696 chr11:48133526 G/A cg15704280 chr7:45808275 SEPT13 -0.63 -7.32 -0.41 3.02e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs4642101 0.597 rs9839768 chr3:12821403 C/T cg24848339 chr3:12840334 CAND2 0.39 6.1 0.35 3.65e-9 QRS complex (12-leadsum); CESC cis rs4073582 0.595 rs801734 chr11:65931216 T/C cg14036092 chr11:66035641 RAB1B 0.54 7.56 0.42 6.63e-13 Gout; CESC cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg12641515 chr19:46296257 DMWD -0.54 -6.33 -0.36 1.02e-9 Coronary artery disease; CESC cis rs8170 0.603 rs971693 chr19:17422649 G/C cg04749549 chr19:17459798 NA -0.33 -5.19 -0.3 4.13e-7 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CESC cis rs8062405 0.755 rs12445823 chr16:28588049 A/C cg01378222 chr16:28622494 SULT1A1 0.3 5.09 0.3 6.77e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg02297831 chr4:17616191 MED28 0.61 7.82 0.43 1.23e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7267979 1.000 rs6050598 chr20:25397257 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.86 18.01 0.74 6.69e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.61 0.42 4.95e-13 Prudent dietary pattern; CESC cis rs17209837 0.607 rs4148821 chr7:87079602 G/C cg00919237 chr7:87102261 ABCB4 -0.52 -6.69 -0.38 1.3e-10 Gallbladder cancer; CESC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.91 0.34 1.03e-8 Tonsillectomy; CESC cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg08704250 chr15:31115839 NA -0.71 -9.06 -0.49 2.94e-17 Huntington's disease progression; CESC cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg02079420 chr8:82753780 SNX16 0.54 8.01 0.44 3.69e-14 Diastolic blood pressure; CESC cis rs7927771 0.839 rs11039308 chr11:47622412 G/A cg20307385 chr11:47447363 PSMC3 -0.42 -5.16 -0.3 4.79e-7 Subjective well-being; CESC cis rs7219021 0.705 rs999475 chr17:46988044 C/T cg16584676 chr17:46985605 UBE2Z -0.61 -7.13 -0.4 9.68e-12 Schizophrenia or bipolar disorder; CESC cis rs2932538 0.961 rs6537747 chr1:113179597 C/T cg22162597 chr1:113214053 CAPZA1 -0.49 -6.49 -0.37 4.14e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg14393609 chr7:65229607 NA -0.45 -5.98 -0.34 7.2e-9 Aortic root size; CESC trans rs208520 0.690 rs12204512 chr6:66710486 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.41 0.61 3.59e-28 Exhaled nitric oxide output; CESC trans rs7615952 0.599 rs6803160 chr3:125709554 G/T cg07211511 chr3:129823064 LOC729375 -0.57 -6.53 -0.37 3.29e-10 Blood pressure (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24816464 chr3:86061715 CADM2 -0.58 -6.89 -0.39 4.17e-11 Gut microbiome composition (summer); CESC cis rs4790333 0.562 rs2447108 chr17:2257993 C/T cg02569219 chr17:2266849 SGSM2 0.39 5.15 0.3 5e-7 Proinsulin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22939802 chr11:118024134 SCN4B 0.51 6.74 0.38 9.58e-11 Gut microbiome composition (summer); CESC cis rs55788414 0.932 rs28514797 chr16:81185070 G/A cg06400318 chr16:81190750 PKD1L2 -0.6 -6.82 -0.39 6.19e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg10862848 chr6:42927986 GNMT -0.31 -7.73 -0.43 2.2e-13 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4604732 0.603 rs10802512 chr1:247633730 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.45 6.62 0.38 2.03e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2952156 0.959 rs907087 chr17:37828787 G/A cg20243544 chr17:37824526 PNMT 0.67 8.24 0.45 8.01e-15 Asthma; CESC cis rs7255436 0.965 rs7254882 chr19:8453822 A/G cg16745616 chr19:8428856 ANGPTL4 -0.39 -5.88 -0.34 1.2e-8 HDL cholesterol; CESC cis rs854765 0.583 rs8070722 chr17:17813562 C/T cg04398451 chr17:18023971 MYO15A -0.67 -9.59 -0.51 6.66e-19 Total body bone mineral density; CESC cis rs2425143 1.000 rs1970357 chr20:34339200 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.8 7.3 0.41 3.39e-12 Blood protein levels; CESC cis rs17376456 0.809 rs10476602 chr5:93445255 T/C cg21475434 chr5:93447410 FAM172A 0.81 7.64 0.42 3.93e-13 Diabetic retinopathy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05985164 chr12:57881757 MARS -0.38 -6.29 -0.36 1.33e-9 Gambling; CESC cis rs9814567 1.000 rs13071551 chr3:134310867 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.06 0.35 4.58e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1670533 1.000 rs641987 chr4:1077542 C/T cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.88e-7 Recombination rate (females); CESC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg22535103 chr8:58192502 C8orf71 -0.95 -9.94 -0.52 5.59e-20 Developmental language disorder (linguistic errors); CESC cis rs12701220 0.803 rs12701432 chr7:1052453 C/T cg26769984 chr7:1090371 C7orf50 0.52 6.04 0.35 5.25e-9 Bronchopulmonary dysplasia; CESC cis rs6502050 0.805 rs8082653 chr17:80162382 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.15 -0.3 4.98e-7 Life satisfaction; CESC cis rs9318086 0.712 rs12875437 chr13:24453956 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.43 6.17 0.35 2.48e-9 Myopia (pathological); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06296553 chr12:124810874 NCOR2 -0.55 -6.54 -0.37 3.18e-10 Gut microbiome composition (summer); CESC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg23754390 chr11:835074 CD151 0.33 5.99 0.35 6.98e-9 Mean platelet volume; CESC cis rs3733585 0.699 rs4339211 chr4:9947658 C/T cg00071950 chr4:10020882 SLC2A9 -0.73 -12.14 -0.6 2.87e-27 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6448317 0.954 rs13116026 chr4:24922242 T/A cg21108841 chr4:24914750 CCDC149 -0.56 -6.71 -0.38 1.2e-10 Heschl's gyrus morphology; CESC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg15383120 chr6:291909 DUSP22 -0.68 -8.82 -0.48 1.55e-16 Menopause (age at onset); CESC cis rs61931739 0.817 rs1687002 chr12:34170263 T/C cg19457237 chr12:34500585 NA -0.37 -5.23 -0.31 3.38e-7 Morning vs. evening chronotype; CESC cis rs2486288 0.656 rs7165039 chr15:45570413 C/G cg21132104 chr15:45694354 SPATA5L1 -0.57 -6.66 -0.38 1.55e-10 Glomerular filtration rate; CESC cis rs894734 0.535 rs2366144 chr12:54324069 G/T cg12374095 chr12:54320830 NA -0.36 -5.22 -0.31 3.67e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CESC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg04166393 chr7:2884313 GNA12 0.63 8.13 0.45 1.62e-14 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05060602 chr4:183838922 DCTD 0.46 6.07 0.35 4.38e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg22535103 chr8:58192502 C8orf71 -0.9 -8.84 -0.48 1.37e-16 Developmental language disorder (linguistic errors); CESC cis rs3808502 0.525 rs13280813 chr8:11425105 G/T cg27411982 chr8:10470053 RP1L1 -0.42 -5.08 -0.3 7.13e-7 Neuroticism; CESC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg14703610 chr5:56206110 C5orf35 0.42 5.19 0.3 4.13e-7 Coronary artery disease; CESC cis rs10905065 0.965 rs10795541 chr10:5811954 A/G cg11519256 chr10:5708881 ASB13 -0.45 -6.23 -0.36 1.86e-9 Menopause (age at onset); CESC cis rs7666738 0.830 rs991168 chr4:98928293 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg13777783 chr17:79615861 NA 0.37 6.32 0.36 1.12e-9 Eye color traits; CESC cis rs3793683 0.520 rs4880426 chr10:134590610 G/A cg18305652 chr10:134549665 INPP5A 0.5 7.2 0.4 6.35e-12 Migraine; CESC trans rs4904167 0.812 rs1779551 chr14:84641871 C/T cg11516540 chr7:4743394 FOXK1 -0.47 -6.18 -0.35 2.46e-9 Autism spectrum disorder or schizophrenia; CESC cis rs15676 0.561 rs10739736 chr9:131577981 A/T cg00228799 chr9:131580591 ENDOG 0.44 5.45 0.32 1.16e-7 Blood metabolite levels; CESC cis rs7208859 0.673 rs216424 chr17:28943064 T/G cg19761014 chr17:28927070 LRRC37B2 0.91 8.53 0.46 1.13e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18815539 chr4:25162020 SEPSECS -0.55 -6.54 -0.37 3.23e-10 Gut microbiome composition (summer); CESC cis rs6674176 0.660 rs6680421 chr1:44408969 A/C cg15962314 chr1:44399869 ARTN -0.27 -5.1 -0.3 6.54e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs778371 0.723 rs1973675 chr2:233636450 C/T cg08000102 chr2:233561755 GIGYF2 -0.82 -14.35 -0.66 6.24e-35 Schizophrenia; CESC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg08704250 chr15:31115839 NA -0.6 -7.54 -0.42 7.32e-13 Huntington's disease progression; CESC cis rs6998277 0.830 rs965661 chr8:103597586 C/T cg10187029 chr8:103597600 NA 0.75 9.93 0.52 5.94e-20 Migraine; CESC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg18490616 chr2:88469792 THNSL2 -0.52 -7.69 -0.43 2.81e-13 Response to metformin (IC50); CESC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg07701084 chr6:150067640 NUP43 0.44 6.25 0.36 1.62e-9 Lung cancer; CESC cis rs2594989 1.000 rs2594989 chr3:11316143 C/T cg00170343 chr3:11313890 ATG7 0.58 5.35 0.31 1.87e-7 Circulating chemerin levels; CESC cis rs2932538 0.922 rs12143068 chr1:113138110 A/G cg22162597 chr1:113214053 CAPZA1 0.54 7.08 0.4 1.3e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs7208859 0.573 rs216442 chr17:28931197 T/G cg13385521 chr17:29058706 SUZ12P 0.77 5.67 0.33 3.8e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.44 5.23 0.31 3.52e-7 Renal function-related traits (BUN); CESC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg11764359 chr7:65958608 NA -0.72 -9.45 -0.5 1.81e-18 Aortic root size; CESC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg04369109 chr6:150039330 LATS1 -0.4 -5.4 -0.31 1.48e-7 Lung cancer; CESC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg25985355 chr7:65971099 NA -0.31 -5.14 -0.3 5.33e-7 Aortic root size; CESC cis rs10876993 0.890 rs774888 chr12:58036506 A/G cg18357645 chr12:58087776 OS9 0.59 9.03 0.49 3.56e-17 Celiac disease or Rheumatoid arthritis; CESC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg14393609 chr7:65229607 NA 0.52 7.11 0.4 1.1e-11 Aortic root size; CESC cis rs4474465 0.688 rs10751296 chr11:78277277 C/T cg27205649 chr11:78285834 NARS2 -0.5 -6.69 -0.38 1.33e-10 Alzheimer's disease (survival time); CESC cis rs1008375 0.932 rs7677212 chr4:17675932 A/G cg02297831 chr4:17616191 MED28 -0.46 -5.49 -0.32 9.64e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9325144 0.560 rs7304568 chr12:38632408 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.53 -0.32 7.66e-8 Morning vs. evening chronotype; CESC cis rs854765 0.583 rs11078405 chr17:17824978 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.53 7.31 0.41 3.19e-12 Total body bone mineral density; CESC cis rs7254114 0.578 rs4804574 chr19:11317482 G/A cg02815516 chr19:11306319 KANK2 0.41 6.63 0.38 1.92e-10 Immature fraction of reticulocytes; CESC cis rs57506017 0.585 rs10950394 chr7:12263587 C/T cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.51e-7 Neuroticism; CESC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg08470875 chr2:26401718 FAM59B -0.7 -7.43 -0.41 1.54e-12 Gut microbiome composition (summer); CESC cis rs12530845 0.673 rs73725437 chr7:135327853 G/A cg23117316 chr7:135346802 PL-5283 -0.55 -6.2 -0.36 2.17e-9 Red blood cell traits; CESC cis rs9457247 0.967 rs2769346 chr6:167370999 A/G cg23791538 chr6:167370224 RNASET2 0.61 8.65 0.47 5.15e-16 Crohn's disease; CESC cis rs2295499 0.643 rs12509102 chr4:2710962 G/C cg08330972 chr4:2403930 ZFYVE28 -0.33 -5.41 -0.32 1.41e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs858239 0.633 rs858300 chr7:23244631 A/G cg23682824 chr7:23144976 KLHL7 0.42 5.62 0.33 4.85e-8 Cerebrospinal fluid biomarker levels; CESC cis rs1215050 0.716 rs11940331 chr4:99054041 G/C cg05340658 chr4:99064831 C4orf37 0.59 7.92 0.44 6.47e-14 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9287719 0.967 rs7600820 chr2:10740044 A/G cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg18230493 chr5:56204884 C5orf35 -0.66 -8.28 -0.45 6.32e-15 Initial pursuit acceleration; CESC cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 7.6 0.42 5.28e-13 Personality dimensions; CESC cis rs9488822 0.596 rs13192549 chr6:116338352 C/A cg05304507 chr6:116381966 FRK 0.22 5.44 0.32 1.21e-7 Cholesterol, total;LDL cholesterol; CESC trans rs3741404 0.791 rs7102177 chr11:63909228 T/C cg15268290 chr11:83690587 DLG2 0.43 6.04 0.35 5.23e-9 Platelet count; CESC trans rs1814175 0.817 rs11040651 chr11:49938395 G/A cg03929089 chr4:120376271 NA -0.93 -15.69 -0.69 1.12e-39 Height; CESC cis rs9902453 0.765 rs12601647 chr17:28164953 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.77 10.29 0.53 4.06e-21 Coffee consumption (cups per day); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27605355 chr17:74472963 RHBDF2 0.45 6.78 0.38 7.79e-11 Fibrinogen levels; CESC cis rs7511006 0.895 rs5771270 chr22:50682865 G/A cg16473166 chr22:50639996 SELO 0.49 6.16 0.35 2.76e-9 Obesity-related traits; CESC cis rs17376456 0.569 rs10067754 chr5:93093110 T/A cg25358565 chr5:93447407 FAM172A 0.68 7.24 0.41 5.01e-12 Diabetic retinopathy; CESC cis rs9359856 0.510 rs74437492 chr6:90338728 A/G cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.79 -0.43 1.55e-13 Bipolar disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10522326 chr1:16134171 UQCRHL -0.51 -6.96 -0.39 2.75e-11 Asthma; CESC trans rs1814175 0.712 rs9665784 chr11:50030617 C/T cg03929089 chr4:120376271 NA -0.94 -16.17 -0.7 2.25e-41 Height; CESC cis rs10979 1.000 rs9376756 chr6:143886125 C/T cg25407410 chr6:143891975 LOC285740 -0.53 -7.64 -0.42 4.07e-13 Hypospadias; CESC cis rs5769765 0.505 rs4561759 chr22:50256686 C/T cg02269571 chr22:50332266 NA 0.46 5.46 0.32 1.08e-7 Schizophrenia; CESC cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.31 -5.14 -0.3 5.27e-7 Hemoglobin concentration; CESC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC trans rs7307889 0.793 rs7486988 chr12:6009745 C/A cg18407955 chr7:158110685 PTPRN2 -0.69 -6.46 -0.37 4.88e-10 Obesity-related traits; CESC cis rs7680126 0.633 rs2868937 chr4:10303081 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -6.2 -0.36 2.1e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs17376456 0.877 rs10061080 chr5:93420559 A/G cg21475434 chr5:93447410 FAM172A 0.83 7.47 0.42 1.18e-12 Diabetic retinopathy; CESC cis rs7615952 0.932 rs7630077 chr3:125649676 T/C cg05084668 chr3:125655381 ALG1L -0.51 -5.95 -0.34 8.3e-9 Blood pressure (smoking interaction); CESC cis rs11122272 0.735 rs2808585 chr1:231514218 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs2760061 0.598 rs849904 chr1:228137145 G/C cg01973587 chr1:228161476 NA 0.38 5.84 0.34 1.54e-8 Diastolic blood pressure; CESC cis rs7255436 0.965 rs4044435 chr19:8448177 T/C cg10174797 chr19:8464628 RAB11B 0.36 5.09 0.3 6.92e-7 HDL cholesterol; CESC cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg14092988 chr3:52407081 DNAH1 0.41 5.4 0.31 1.52e-7 Bipolar disorder; CESC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg10883421 chr6:151773342 RMND1;C6orf211 0.86 14.41 0.66 3.84e-35 Menarche (age at onset); CESC cis rs3106136 0.609 rs12500027 chr4:95107918 T/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.29 -0.36 1.34e-9 Capecitabine sensitivity; CESC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg06873352 chr17:61820015 STRADA 0.73 13.09 0.63 1.57e-30 Prudent dietary pattern; CESC cis rs7520050 0.966 rs7524495 chr1:46266932 T/C cg03146154 chr1:46216737 IPP -0.47 -6.19 -0.36 2.34e-9 Red blood cell count;Reticulocyte count; CESC cis rs7072216 0.763 rs1061437 chr10:100176154 C/T cg26618903 chr10:100175079 PYROXD2 -0.37 -5.65 -0.33 4.05e-8 Metabolite levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04579211 chr15:41221939 DLL4 0.46 6.22 0.36 1.88e-9 Gut microbiota (bacterial taxa); CESC cis rs6967414 0.579 rs11980762 chr7:6756878 G/A cg09896999 chr7:6746977 ZNF12 -0.52 -6.19 -0.36 2.31e-9 Hematocrit;Hemoglobin concentration; CESC cis rs1808579 0.904 rs1652343 chr18:21131929 T/C cg14672496 chr18:21087552 C18orf8 0.42 6.09 0.35 3.92e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs9788333 0.707 rs12584557 chr13:21886171 C/A cg21970626 chr13:21893289 NA -0.41 -6.3 -0.36 1.23e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg11644478 chr21:40555479 PSMG1 1.01 16.61 0.71 6.05e-43 Cognitive function; CESC cis rs4979906 1.000 rs4979786 chr10:79444965 T/C cg07817648 chr10:79422355 NA -0.61 -6.53 -0.37 3.37e-10 Mortality in heart failure; CESC cis rs7119 1.000 rs7119 chr15:77777632 C/T cg17802220 chr15:77601643 NA -0.34 -5.31 -0.31 2.34e-7 Type 2 diabetes; CESC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg10150615 chr22:24372951 LOC391322 -0.53 -7.12 -0.4 1.01e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1570884 0.516 rs2094108 chr13:50171550 G/A cg08779649 chr13:50194554 NA 0.39 6.71 0.38 1.17e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs950776 0.518 rs12915428 chr15:78823368 G/A cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs7072216 0.763 rs3814140 chr10:100170762 C/T cg26618903 chr10:100175079 PYROXD2 -0.38 -5.79 -0.34 1.99e-8 Metabolite levels; CESC cis rs748404 0.631 rs6493084 chr15:43647627 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.42 0.46 2.44e-15 Lung cancer; CESC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg14709524 chr16:89940631 TCF25 -0.82 -6.46 -0.37 4.99e-10 Skin colour saturation; CESC cis rs4700695 0.668 rs36837 chr5:65480007 C/A cg21114390 chr5:65439923 SFRS12 -0.47 -5.71 -0.33 2.96e-8 Facial morphology (factor 19); CESC cis rs7659604 1.000 rs34952897 chr4:122664409 C/T cg19671926 chr4:122722719 EXOSC9 -0.44 -5.21 -0.3 3.76e-7 Type 2 diabetes; CESC cis rs7777484 0.534 rs2533890 chr7:2828743 C/T cg09658497 chr7:2847517 GNA12 -0.46 -7.11 -0.4 1.1e-11 Height; CESC cis rs9486715 0.758 rs2971610 chr6:97027380 C/T cg06623918 chr6:96969491 KIAA0776 -0.95 -15.19 -0.68 6.76e-38 Headache; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg14871650 chr4:170541668 CLCN3 0.53 6.54 0.37 3.09e-10 Bronchopulmonary dysplasia; CESC cis rs7786877 0.761 rs11772705 chr7:100298904 T/C cg20848291 chr7:100343083 ZAN -0.78 -9.93 -0.52 5.71e-20 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs5850 0.602 rs1005786 chr7:23145837 G/C cg27449745 chr7:23145252 KLHL7 -0.58 -7.72 -0.43 2.32e-13 Blood protein levels; CESC cis rs1707322 1.000 rs9803784 chr1:46401907 T/C cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.835 rs3935816 chr17:80137173 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.05 -0.3 8.38e-7 Life satisfaction; CESC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14290704 chr9:2015039 SMARCA2 -0.57 -6.75 -0.38 9.11e-11 Gut microbiome composition (summer); CESC cis rs9303401 0.614 rs66480139 chr17:57101538 G/A cg12560992 chr17:57184187 TRIM37 0.5 5.26 0.31 2.91e-7 Cognitive test performance; CESC cis rs12681288 0.862 rs7015529 chr8:1020249 A/G cg15309053 chr8:964076 NA 0.39 6.44 0.37 5.74e-10 Schizophrenia; CESC cis rs11785400 1.000 rs3735994 chr8:143742683 C/T cg10596483 chr8:143751796 JRK 0.43 5.65 0.33 4.1e-8 Schizophrenia; CESC cis rs708547 1.000 rs10003229 chr4:57809598 A/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.68 -7.05 -0.4 1.54e-11 Response to bleomycin (chromatid breaks); CESC cis rs7680126 0.596 rs917826 chr4:10295595 C/G cg00071950 chr4:10020882 SLC2A9 -0.53 -5.95 -0.34 8.63e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15652120 chr12:96588210 ELK3 0.51 6.79 0.38 7.4e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2295499 0.754 rs12499258 chr4:2715758 G/A cg08330972 chr4:2403930 ZFYVE28 -0.34 -5.54 -0.32 7.22e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs9457247 0.765 rs4710171 chr6:167430186 A/G cg23791538 chr6:167370224 RNASET2 -0.54 -7.44 -0.42 1.37e-12 Crohn's disease; CESC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg22549504 chr19:17448937 GTPBP3 0.49 5.52 0.32 8.25e-8 Systemic lupus erythematosus; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21800906 chr11:32914818 QSER1 0.54 7.15 0.4 8.24e-12 Gut microbiota (bacterial taxa); CESC cis rs17807624 1.000 rs17807624 chr8:11463015 A/G cg21775007 chr8:11205619 TDH -0.4 -5.92 -0.34 1.02e-8 Systemic lupus erythematosus; CESC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.51 0.54 8.06e-22 Prudent dietary pattern; CESC cis rs816535 1 rs816535 chr20:26255996 C/T cg20395967 chr20:26190347 MIR663 0.27 5.05 0.3 8.39e-7 Parkinson disease and lewy body pathology; CESC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg24060327 chr5:131705240 SLC22A5 -0.48 -6.27 -0.36 1.45e-9 Acylcarnitine levels; CESC cis rs4654899 0.828 rs4654735 chr1:21432001 T/C cg05370193 chr1:21551575 ECE1 0.4 6.16 0.35 2.68e-9 Superior frontal gyrus grey matter volume; CESC cis rs660498 0.507 rs34354872 chr10:27735673 T/G cg08398567 chr10:27609333 NA 0.39 5.29 0.31 2.61e-7 Asthma (childhood onset); CESC trans rs11039798 0.764 rs11040030 chr11:48800985 C/T cg15704280 chr7:45808275 SEPT13 0.71 6.44 0.37 5.59e-10 Axial length; CESC trans rs3780486 0.846 rs10758192 chr9:33131651 G/A cg20290983 chr6:43655470 MRPS18A 0.99 18.35 0.75 4.06e-49 IgG glycosylation; CESC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg05234568 chr11:5960015 NA -0.62 -8.76 -0.47 2.37e-16 DNA methylation (variation); CESC cis rs72781680 0.715 rs72796332 chr2:24142060 G/A cg08917208 chr2:24149416 ATAD2B 0.57 5.62 0.33 4.79e-8 Lymphocyte counts; CESC cis rs644799 0.582 rs473157 chr11:95596874 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.56 7.26 0.41 4.34e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs3780486 0.757 rs10758189 chr9:33125804 A/G cg20290983 chr6:43655470 MRPS18A 0.97 17.6 0.73 1.83e-46 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03449513 chr6:51275386 NA -0.6 -7.26 -0.41 4.35e-12 Gut microbiome composition (summer); CESC cis rs911555 0.755 rs6575988 chr14:103900827 G/T cg24130564 chr14:104152367 KLC1 0.52 7.2 0.4 6.15e-12 Intelligence (multi-trait analysis); CESC cis rs2997447 0.655 rs12094933 chr1:26374779 T/C cg19633962 chr1:26362018 EXTL1 -0.49 -5.3 -0.31 2.39e-7 QRS complex (12-leadsum); CESC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg23281280 chr6:28129359 ZNF389 0.42 6.23 0.36 1.84e-9 Cardiac Troponin-T levels; CESC cis rs1023500 0.596 rs133350 chr22:42429049 A/G cg15557168 chr22:42548783 NA -0.39 -5.2 -0.3 3.9e-7 Schizophrenia; CESC cis rs11645898 0.935 rs72787078 chr16:72158493 C/T cg14768367 chr16:72042858 DHODH -0.71 -6.06 -0.35 4.62e-9 Blood protein levels; CESC cis rs6963495 0.818 rs9769403 chr7:105163091 G/A cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.88e-8 Lung cancer; CESC cis rs1790761 0.505 rs7941395 chr11:67347417 A/G cg14500267 chr11:67383377 NA -0.31 -5.12 -0.3 5.81e-7 Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12598099 chr18:60189407 ZCCHC2 0.46 6.55 0.37 3.01e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9915657 0.933 rs17246133 chr17:70140485 A/G cg06234051 chr17:70120541 SOX9 -0.36 -5.43 -0.32 1.26e-7 Thyroid hormone levels; CESC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.55 0.37 2.91e-10 Prudent dietary pattern; CESC cis rs9611565 0.559 rs4822048 chr22:41988225 C/T cg17376030 chr22:41985996 PMM1 0.81 8.45 0.46 1.98e-15 Vitiligo; CESC cis rs28647808 0.748 rs114667516 chr9:136258537 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg18769074 chr3:133464867 TF 0.3 5.75 0.33 2.44e-8 Iron status biomarkers; CESC cis rs1707322 0.613 rs1473840 chr1:46601197 A/G cg06784218 chr1:46089804 CCDC17 -0.34 -5.35 -0.31 1.88e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9309473 0.718 rs6546829 chr2:73613789 C/G cg20560298 chr2:73613845 ALMS1 -0.5 -6.76 -0.38 8.74e-11 Metabolite levels; CESC cis rs72781680 0.706 rs72796108 chr2:23904990 C/A cg20701182 chr2:24300061 SF3B14 0.79 6.83 0.39 5.68e-11 Lymphocyte counts; CESC cis rs55823223 0.680 rs57287238 chr17:73850940 T/C cg10935138 chr17:73851978 WBP2 0.84 9.76 0.51 2.08e-19 Psoriasis; CESC cis rs3820068 0.608 rs10927836 chr1:16034368 G/C cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.35 4.28e-9 Systolic blood pressure; CESC cis rs2243480 0.901 rs778693 chr7:65872345 T/G cg13147721 chr7:65941812 NA -0.95 -8.95 -0.48 6.27e-17 Diabetic kidney disease; CESC cis rs10479542 0.929 rs10078796 chr5:178978883 T/A cg09060608 chr5:178986726 RUFY1 0.51 7.81 0.43 1.38e-13 Lung cancer; CESC cis rs2294693 0.679 rs4317403 chr6:40971173 C/T cg14418226 chr6:40996092 UNC5CL 0.48 5.26 0.31 2.99e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg03467027 chr4:99064603 C4orf37 0.42 5.29 0.31 2.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3733585 0.753 rs1122141 chr4:9947278 T/C cg02734326 chr4:10020555 SLC2A9 -0.45 -6.7 -0.38 1.25e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.86 8.35 0.46 3.88e-15 Schizophrenia; CESC cis rs10200159 1.000 rs6760959 chr2:55821501 T/A cg13617705 chr2:55845095 SMEK2 0.68 5.13 0.3 5.67e-7 Vitiligo; CESC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg18765753 chr7:1198926 ZFAND2A -0.4 -5.99 -0.35 6.84e-9 Longevity;Endometriosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27497049 chr8:94712646 FAM92A1 -0.48 -6.7 -0.38 1.23e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3733585 0.673 rs10018204 chr4:9964570 C/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.77 -0.59 5.14e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.47 0.46 1.75e-15 Colonoscopy-negative controls vs population controls; CESC cis rs936229 0.871 rs2290574 chr15:75135447 T/C cg14664628 chr15:75095509 CSK -0.84 -11.18 -0.57 4.95e-24 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs11098499 0.954 rs10031665 chr4:120422852 T/C cg09307838 chr4:120376055 NA 0.93 13.08 0.63 1.67e-30 Corneal astigmatism; CESC trans rs4424809 1.000 rs76502189 chr13:85278841 A/G cg22095490 chr18:77560089 NA -0.87 -6.37 -0.36 8.48e-10 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg22929018 chr2:207024348 EEF1B2;NDUFS1 -0.47 -6.31 -0.36 1.14e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs909002 0.800 rs10914459 chr1:32096918 T/C cg13919466 chr1:32135498 COL16A1 -0.45 -8.04 -0.44 2.96e-14 Intelligence (multi-trait analysis); CESC cis rs10779751 1.000 rs6679878 chr1:11306882 A/G cg08854313 chr1:11322531 MTOR 0.8 10.84 0.55 6.7e-23 Body mass index; CESC cis rs72781680 0.611 rs7602797 chr2:24318148 C/T cg06627628 chr2:24431161 ITSN2 -0.68 -6.58 -0.37 2.44e-10 Lymphocyte counts; CESC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg10691866 chr7:65817282 TPST1 0.31 5.18 0.3 4.45e-7 Aortic root size; CESC cis rs798766 1.000 rs1665364 chr4:1727206 A/G cg07041428 chr4:1763019 NA 0.39 5.34 0.31 2.03e-7 Bladder cancer;Urinary bladder cancer; CESC cis rs3733585 0.699 rs4515163 chr4:9959603 C/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2294693 0.945 rs11756893 chr6:41010058 A/C cg14418226 chr6:40996092 UNC5CL 0.5 5.75 0.33 2.42e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs9399135 0.967 rs11755229 chr6:135369913 A/G cg24558204 chr6:135376177 HBS1L 0.49 6.77 0.38 8.11e-11 Red blood cell count; CESC trans rs11098499 0.530 rs114866537 chr4:120258608 A/T cg25214090 chr10:38739885 LOC399744 0.61 8.64 0.47 5.37e-16 Corneal astigmatism; CESC cis rs672059 1.000 rs563026 chr1:183161037 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.55 -7.11 -0.4 1.06e-11 Hypertriglyceridemia; CESC cis rs7726839 0.540 rs72705097 chr5:655067 G/A cg16447950 chr5:562315 NA -0.58 -6.53 -0.37 3.38e-10 Obesity-related traits; CESC cis rs8062405 1.000 rs72793812 chr16:28840381 A/G cg05966235 chr16:28915196 ATP2A1 0.35 5.12 0.3 5.8e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9596863 0.821 rs4884722 chr13:54429821 C/A ch.13.53330881F chr13:54432880 NA -0.63 -5.37 -0.31 1.74e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg05313129 chr8:58192883 C8orf71 -0.56 -6.49 -0.37 4.31e-10 Developmental language disorder (linguistic errors); CESC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg24675658 chr1:53192096 ZYG11B -0.65 -8.83 -0.48 1.43e-16 Monocyte count; CESC cis rs910316 1.000 rs3742773 chr14:75579643 A/G cg08847533 chr14:75593920 NEK9 1.0 19.49 0.77 4.1e-53 Height; CESC cis rs8070128 0.601 rs8080602 chr17:17954728 G/C cg04398451 chr17:18023971 MYO15A 0.73 10.55 0.54 5.95e-22 Total body bone mineral density; CESC cis rs6714710 0.603 rs895438 chr2:98382886 G/A cg26665480 chr2:98280029 ACTR1B 0.68 9.18 0.49 1.31e-17 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs10463316 0.894 rs6579863 chr5:150761946 A/T cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC cis rs4595586 0.679 rs5017082 chr12:39314564 A/C cg26384229 chr12:38710491 ALG10B -0.41 -6.03 -0.35 5.42e-9 Morning vs. evening chronotype; CESC cis rs7520050 0.778 rs3013597 chr1:46128356 C/A cg24296786 chr1:45957014 TESK2 -0.47 -6.17 -0.35 2.61e-9 Red blood cell count;Reticulocyte count; CESC cis rs2243480 1.000 rs958550 chr7:65635679 C/T cg18252515 chr7:66147081 NA 1.22 11.33 0.57 1.59e-24 Diabetic kidney disease; CESC cis rs9611565 0.512 rs4820446 chr22:42215684 C/T cg06481639 chr22:41940642 POLR3H -0.58 -5.71 -0.33 3.03e-8 Vitiligo; CESC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.34 0.41 2.67e-12 Depression; CESC trans rs1814175 0.935 rs7479914 chr11:49661351 T/C cg15704280 chr7:45808275 SEPT13 -1.0 -17.79 -0.74 4.04e-47 Height; CESC cis rs7605378 0.752 rs769960 chr2:200710706 G/T cg23649088 chr2:200775458 C2orf69 -0.58 -7.37 -0.41 2.12e-12 Osteoporosis; CESC cis rs7000551 0.689 rs2469753 chr8:22383225 T/C cg12081754 chr8:22256438 SLC39A14 0.39 5.22 0.31 3.56e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12497850 0.931 rs7616815 chr3:48779715 C/T cg03060546 chr3:49711283 APEH 0.4 5.03 0.3 9.02e-7 Parkinson's disease; CESC cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.74 10.8 0.55 8.88e-23 Hip circumference adjusted for BMI; CESC cis rs7249142 0.562 rs10418053 chr19:19287164 A/G cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.28 5.06 0.3 7.92e-7 IgG glycosylation; CESC cis rs11098499 0.866 rs6847778 chr4:120293582 A/G cg09307838 chr4:120376055 NA 0.87 11.85 0.59 2.74e-26 Corneal astigmatism; CESC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg02475777 chr4:1388615 CRIPAK -0.47 -6.05 -0.35 4.85e-9 Obesity-related traits; CESC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg05368731 chr17:41323189 NBR1 0.8 11.09 0.56 9.98e-24 Menopause (age at onset); CESC cis rs999943 0.846 rs999942 chr6:33624902 G/C cg14003231 chr6:33640908 ITPR3 0.7 12.36 0.6 4.99e-28 Obesity (extreme); CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg12419862 chr22:24373484 LOC391322 -0.8 -11.75 -0.59 6.16e-26 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1797885 0.934 rs2648312 chr3:12547147 C/T cg26432171 chr3:12704882 RAF1 0.46 5.67 0.33 3.78e-8 Immature fraction of reticulocytes; CESC cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg05927159 chr4:10118984 WDR1 0.35 5.11 0.3 6.14e-7 Cleft plate (environmental tobacco smoke interaction); CESC trans rs8073060 0.586 rs2523114 chr17:34023762 G/A cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs11785693 0.862 rs11783719 chr8:4991311 G/T cg26367366 chr8:4980734 NA 0.88 8.07 0.44 2.52e-14 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs6460942 1.000 rs7791634 chr7:12401482 A/T cg06484146 chr7:12443880 VWDE -0.7 -8.06 -0.44 2.57e-14 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14223017 chr19:2151266 AP3D1 0.49 6.99 0.39 2.29e-11 Gut microbiota (bacterial taxa); CESC cis rs8038465 0.622 rs7182124 chr15:73915254 C/T cg15420318 chr15:73925796 NPTN 0.49 6.9 0.39 3.75e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg04944784 chr2:26401820 FAM59B -0.66 -7.66 -0.43 3.61e-13 Gut microbiome composition (summer); CESC cis rs6714710 0.603 rs6738389 chr2:98386731 A/G cg26665480 chr2:98280029 ACTR1B 0.6 8.42 0.46 2.46e-15 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs9443645 0.803 rs12195716 chr6:79535412 T/C cg05283184 chr6:79620031 NA -0.44 -6.88 -0.39 4.19e-11 Intelligence (multi-trait analysis); CESC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg11644478 chr21:40555479 PSMG1 -0.79 -11.6 -0.58 1.99e-25 Cognitive function; CESC cis rs2066819 0.818 rs773652 chr12:56674766 G/A cg26316697 chr12:56727976 PAN2 -0.69 -6.64 -0.38 1.74e-10 Psoriasis vulgaris; CESC cis rs9457247 0.846 rs2757052 chr6:167380174 T/C cg23791538 chr6:167370224 RNASET2 0.6 8.57 0.47 8.75e-16 Crohn's disease; CESC cis rs9611565 0.649 rs2064189 chr22:42127999 A/G cg06481639 chr22:41940642 POLR3H 0.47 5.48 0.32 9.85e-8 Vitiligo; CESC cis rs8114671 0.869 rs1407202 chr20:33651967 C/T cg07148914 chr20:33460835 GGT7 -0.4 -5.17 -0.3 4.66e-7 Height; CESC cis rs11190604 1.000 rs11190602 chr10:102297256 T/C cg07080220 chr10:102295463 HIF1AN 0.7 6.5 0.37 3.99e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs4423214 0.840 rs2017686 chr11:71187061 C/G cg05163923 chr11:71159392 DHCR7 -0.68 -7.76 -0.43 1.82e-13 Vitamin D levels; CESC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs76878669 0.606 rs2282531 chr11:66099494 C/T cg18002602 chr11:66138449 SLC29A2 -0.43 -7.1 -0.4 1.13e-11 Educational attainment (years of education); CESC cis rs16867321 0.950 rs12477283 chr2:181501355 G/T cg23363182 chr2:181467187 NA -0.43 -5.69 -0.33 3.39e-8 Obesity; CESC cis rs17666538 1.000 rs61064968 chr8:587933 T/C cg13264159 chr8:625131 ERICH1 0.74 5.14 0.3 5.34e-7 IgG glycosylation; CESC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg05564831 chr3:52568323 NT5DC2 0.46 6.98 0.39 2.33e-11 Bipolar disorder; CESC trans rs2812533 0.689 rs2616070 chr10:71426695 C/G cg23618638 chr7:22123315 NA 0.47 6.19 0.36 2.28e-9 Type 2 diabetes; CESC cis rs367615 0.660 rs10061221 chr5:108839038 C/T cg17395555 chr5:108820864 NA 0.63 11.09 0.56 9.78e-24 Colorectal cancer (SNP x SNP interaction); CESC cis rs870825 0.860 rs11132253 chr4:185595472 C/T cg04058563 chr4:185651563 MLF1IP 0.51 5.23 0.31 3.48e-7 Blood protein levels; CESC cis rs4595586 0.870 rs10444553 chr12:39294076 C/G cg26384229 chr12:38710491 ALG10B 0.36 5.15 0.3 4.97e-7 Morning vs. evening chronotype; CESC cis rs9399135 0.933 rs28384512 chr6:135376232 C/T cg24558204 chr6:135376177 HBS1L 0.5 6.85 0.39 5.08e-11 Red blood cell count; CESC cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg17376030 chr22:41985996 PMM1 -0.62 -6.71 -0.38 1.16e-10 Vitiligo; CESC cis rs2637266 0.703 rs1660907 chr10:78494859 A/C cg18941641 chr10:78392320 NA 0.38 7.26 0.41 4.32e-12 Pulmonary function; CESC cis rs4722166 0.508 rs1474348 chr7:22767908 C/G cg05265849 chr7:22767390 IL6 0.51 6.58 0.37 2.56e-10 Lung cancer; CESC cis rs595982 0.559 rs117227130 chr19:49367959 A/G cg15549821 chr19:49342101 PLEKHA4 -0.71 -7.96 -0.44 5.22e-14 Red cell distribution width; CESC cis rs7635838 0.859 rs7632040 chr3:11427455 A/G cg00170343 chr3:11313890 ATG7 0.42 5.57 0.32 6.37e-8 HDL cholesterol; CESC cis rs7267979 1.000 rs2027003 chr20:25350498 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -15.92 -0.7 1.72e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs10089 1.000 rs10064357 chr5:127417272 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.3 0.53 3.74e-21 Ileal carcinoids; CESC cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -12.84 -0.62 1.17e-29 Developmental language disorder (linguistic errors); CESC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg03396347 chr1:1875803 NA -0.42 -6.55 -0.37 3.03e-10 Body mass index; CESC cis rs1395 0.813 rs11685326 chr2:27453679 A/G cg22903471 chr2:27725779 GCKR -0.42 -5.13 -0.3 5.64e-7 Blood metabolite levels; CESC cis rs2832191 0.967 rs2251377 chr21:30530599 T/C cg24692254 chr21:30365293 RNF160 0.73 10.75 0.55 1.34e-22 Dental caries; CESC trans rs5757949 0.530 rs139062 chr22:40881793 T/C cg04870523 chr3:115231438 NA -0.36 -6.31 -0.36 1.17e-9 Height; CESC cis rs6964587 0.610 rs7788951 chr7:91468765 A/T cg17063962 chr7:91808500 NA 0.44 5.92 0.34 9.84e-9 Breast cancer; CESC cis rs68170813 0.559 rs17427123 chr7:106823661 G/A cg02696742 chr7:106810147 HBP1 -0.55 -5.32 -0.31 2.24e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04515913 chr15:89182103 ISG20 0.54 6.3 0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg19748678 chr4:122722346 EXOSC9 0.79 9.89 0.52 7.63e-20 Type 2 diabetes; CESC cis rs6728642 1.000 rs113863815 chr2:97657813 A/G cg26665480 chr2:98280029 ACTR1B -0.87 -6.48 -0.37 4.39e-10 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs7116495 1.000 rs482013 chr11:71803962 G/A cg10381502 chr11:71823885 C11orf51 -0.66 -5.4 -0.31 1.51e-7 Severe influenza A (H1N1) infection; CESC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg23590916 chr17:43697445 MGC57346 0.65 6.72 0.38 1.14e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs116095464 0.558 rs7356696 chr5:284251 A/G cg22857025 chr5:266934 NA -1.29 -18.38 -0.75 3.21e-49 Breast cancer; CESC cis rs854765 0.583 rs28428991 chr17:17827649 C/T cg04398451 chr17:18023971 MYO15A -0.67 -9.6 -0.51 6.42e-19 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23586121 chr10:134586462 INPP5A 0.5 6.44 0.37 5.47e-10 Fibrinogen levels; CESC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 12.15 0.6 2.73e-27 Alzheimer's disease; CESC cis rs35110281 0.774 rs1378080 chr21:45011315 T/A cg21573476 chr21:45109991 RRP1B -0.42 -5.66 -0.33 3.93e-8 Mean corpuscular volume; CESC cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.63 7.63 0.42 4.36e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs2380220 0.574 rs9374322 chr6:95998994 G/A cg15832292 chr6:96025679 MANEA 0.63 7.18 0.4 7.12e-12 Behavioural disinhibition (generation interaction); CESC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg11890956 chr21:40555474 PSMG1 -0.66 -9.11 -0.49 2.05e-17 Menarche (age at onset); CESC cis rs250677 0.687 rs42364 chr5:148438858 T/A cg18129178 chr5:148520854 ABLIM3 -0.51 -5.84 -0.34 1.5e-8 Breast cancer; CESC cis rs6500395 1.000 rs8052640 chr16:48604096 G/T cg04672837 chr16:48644449 N4BP1 0.5 6.19 0.36 2.23e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg11494091 chr17:61959527 GH2 -0.76 -14.01 -0.65 9.39e-34 Prudent dietary pattern; CESC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg10691866 chr7:65817282 TPST1 0.32 5.23 0.31 3.41e-7 Aortic root size; CESC cis rs4746818 0.901 rs4746816 chr10:70874866 G/T cg04149295 chr10:70884716 VPS26A 0.59 5.1 0.3 6.57e-7 Left atrial antero-posterior diameter; CESC cis rs2952156 1.000 rs1565923 chr17:37858678 A/G cg07936489 chr17:37558343 FBXL20 -0.5 -5.8 -0.34 1.89e-8 Asthma; CESC cis rs950776 0.616 rs56276142 chr15:78889795 T/C cg06917634 chr15:78832804 PSMA4 0.56 7.31 0.41 3.14e-12 Sudden cardiac arrest; CESC trans rs2727020 0.675 rs1684258 chr11:49340020 G/A cg03929089 chr4:120376271 NA 0.63 6.83 0.39 5.73e-11 Coronary artery disease; CESC cis rs7084402 0.967 rs12569559 chr10:60312711 T/G cg07615347 chr10:60278583 BICC1 -0.58 -8.72 -0.47 3.19e-16 Refractive error; CESC cis rs7208859 0.623 rs8067338 chr17:29102345 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg15445000 chr17:37608096 MED1 -0.4 -6.54 -0.37 3.14e-10 Glomerular filtration rate (creatinine); CESC cis rs7020830 0.823 rs7019699 chr9:37125081 C/A cg14294708 chr9:37120828 ZCCHC7 1.27 25.81 0.85 2.72e-74 Schizophrenia; CESC cis rs472402 0.560 rs2288444 chr5:6619923 A/G cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.48 -6.37 -0.36 8.51e-10 Response to amphetamines; CESC trans rs17211056 0.744 rs2584281 chr18:73347313 C/T cg07370845 chr6:26108434 HIST1H1T -0.7 -6.75 -0.38 9.51e-11 Serum uric acid levels in response to allopurinol in gout; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18394496 chr11:62554881 TMEM179B -0.47 -6.19 -0.36 2.34e-9 Ulcerative colitis; CESC cis rs654950 0.875 rs55865698 chr1:41986758 C/T cg06885757 chr1:42089581 HIVEP3 -0.42 -6.54 -0.37 3.09e-10 Airway imaging phenotypes; CESC cis rs2228479 1.000 rs4257207 chr16:89947861 T/A cg06558623 chr16:89946397 TCF25 1.15 9.14 0.49 1.65e-17 Skin colour saturation; CESC trans rs1945213 0.694 rs34828123 chr11:55837868 T/A cg03929089 chr4:120376271 NA 0.76 7.26 0.41 4.31e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg07167872 chr1:205819463 PM20D1 -0.39 -5.51 -0.32 8.44e-8 Menarche (age at onset); CESC cis rs4604732 0.642 rs10802514 chr1:247637749 A/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.34 5.11 0.3 6.28e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9815354 0.812 rs76966288 chr3:41825055 G/A cg03022575 chr3:42003672 ULK4 0.72 6.35 0.36 9.22e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs3096299 0.746 rs9931120 chr16:89501357 A/G cg02187348 chr16:89574699 SPG7 0.53 6.96 0.39 2.74e-11 Multiple myeloma (IgH translocation); CESC cis rs2439831 0.717 rs2447198 chr15:43895118 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.66 8.31 0.45 5.03e-15 Lung cancer in ever smokers; CESC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg15445000 chr17:37608096 MED1 0.4 6.59 0.38 2.41e-10 Glomerular filtration rate (creatinine); CESC cis rs7223966 0.621 rs9906747 chr17:61639694 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.47 -5.36 -0.31 1.8e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.48 6.21 0.36 2.01e-9 Personality dimensions; CESC cis rs763121 0.889 rs9610971 chr22:38910810 C/T cg14440974 chr22:39074834 NA -0.38 -5.03 -0.3 9.08e-7 Menopause (age at onset); CESC cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg27347728 chr4:17578864 LAP3 0.49 5.58 0.32 5.82e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg04944784 chr2:26401820 FAM59B 0.96 10.83 0.55 7.34e-23 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14312959 chr17:79008933 FLJ90757;BAIAP2 0.69 8.52 0.46 1.23e-15 Gut microbiome composition (summer); CESC cis rs6087990 0.735 rs2424921 chr20:31385814 C/T cg13636640 chr20:31349939 DNMT3B 0.8 13.07 0.63 1.79e-30 Ulcerative colitis; CESC cis rs7520050 0.751 rs2991975 chr1:46024526 A/G cg03146154 chr1:46216737 IPP -0.51 -6.51 -0.37 3.81e-10 Red blood cell count;Reticulocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05590948 chr1:27874430 AHDC1 0.54 7.18 0.4 7e-12 Fibrinogen levels; CESC cis rs11227306 0.934 rs2303384 chr11:65640204 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.49 -5.45 -0.32 1.17e-7 DNA methylation (variation); CESC cis rs36051895 0.659 rs11999076 chr9:5037694 C/T cg02405213 chr9:5042618 JAK2 -0.44 -5.5 -0.32 8.83e-8 Pediatric autoimmune diseases; CESC cis rs1215050 0.791 rs783950 chr4:98878395 C/T cg05340658 chr4:99064831 C4orf37 -0.5 -6.66 -0.38 1.55e-10 Waist-to-hip ratio adjusted for body mass index; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg07806421 chr2:139259153 SPOPL -0.52 -6.12 -0.35 3.33e-9 Gut microbiota (bacterial taxa); CESC cis rs9354308 0.868 rs9345695 chr6:66554270 C/T cg07460842 chr6:66804631 NA -0.43 -5.09 -0.3 6.95e-7 Metabolite levels; CESC cis rs56235845 0.694 rs4976643 chr5:176760227 A/C cg17509989 chr5:176798049 RGS14 0.49 6.05 0.35 4.98e-9 Hemoglobin concentration;Hematocrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00399115 chr16:20911682 DCUN1D3;LYRM1 0.62 7.02 0.4 1.81e-11 Gut microbiome composition (summer); CESC cis rs8114671 0.562 rs6087642 chr20:33468306 T/C cg07148914 chr20:33460835 GGT7 0.45 6.09 0.35 3.95e-9 Height; CESC cis rs17293817 0.589 rs17293789 chr10:1426013 C/T cg04271617 chr10:1416546 ADARB2 0.33 5.27 0.31 2.88e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs10504073 0.584 rs10504070 chr8:49978554 A/G cg00325661 chr8:49890786 NA -0.59 -9.02 -0.48 3.93e-17 Blood metabolite ratios; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg13108601 chr6:41748242 FRS3;PRICKLE4 -0.54 -6.06 -0.35 4.54e-9 Lung cancer in ever smokers; CESC cis rs1008375 1.000 rs11737138 chr4:17657986 G/A cg02297831 chr4:17616191 MED28 0.53 6.75 0.38 9.49e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7524258 0.868 rs7544314 chr1:7266744 G/C cg07173049 chr1:7289937 CAMTA1 0.43 6.36 0.36 8.76e-10 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs2124969 0.506 rs62175396 chr2:161043603 G/A cg03641300 chr2:160917029 PLA2R1 -0.58 -5.99 -0.35 6.85e-9 Waist circumference adjusted for body mass index; CESC cis rs7843479 0.601 rs10101881 chr8:21830158 A/G cg17168535 chr8:21777572 XPO7 0.67 9.95 0.52 5.21e-20 Mean corpuscular volume; CESC cis rs4803455 0.565 rs1800470 chr19:41858921 G/A cg14132834 chr19:41945861 ATP5SL -0.43 -5.04 -0.3 8.46e-7 Migraine;Coronary artery disease; CESC trans rs116095464 0.558 rs55664502 chr5:270485 T/C cg00938859 chr5:1591904 SDHAP3 0.63 6.9 0.39 3.88e-11 Breast cancer; CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg03407747 chr17:6899364 ALOX12 0.49 8.48 0.46 1.57e-15 Tonsillectomy; CESC cis rs2274273 0.686 rs66531545 chr14:55587460 T/C cg04306507 chr14:55594613 LGALS3 0.31 5.45 0.32 1.16e-7 Protein biomarker; CESC trans rs10463316 0.894 rs6864722 chr5:150752942 G/A cg24389359 chr12:111284228 CCDC63 -0.35 -6.17 -0.35 2.52e-9 Metabolite levels (Pyroglutamine); CESC cis rs12291225 0.585 rs11023194 chr11:14369769 T/C cg19336497 chr11:14380999 RRAS2 -0.45 -6.83 -0.39 5.91e-11 Sense of smell; CESC cis rs9309473 0.950 rs2947860 chr2:73855386 A/G cg20560298 chr2:73613845 ALMS1 -0.51 -6.5 -0.37 3.96e-10 Metabolite levels; CESC cis rs962856 1.000 rs1601531 chr2:67598104 T/C cg09028215 chr2:67624308 ETAA1 -0.42 -5.44 -0.32 1.2e-7 Pancreatic cancer; CESC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg17366294 chr4:99064904 C4orf37 0.62 8.91 0.48 8.69e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2011503 0.825 rs4808932 chr19:19358819 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.56 0.32 6.43e-8 Bipolar disorder; CESC cis rs4237845 0.773 rs6650218 chr12:58289078 T/A cg02175503 chr12:58329896 NA 0.63 9.03 0.49 3.6e-17 Intelligence (multi-trait analysis); CESC cis rs28830936 0.966 rs1918310 chr15:42065253 A/C cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.43 -5.98 -0.34 7.31e-9 Diastolic blood pressure; CESC cis rs6964587 1.000 rs12530646 chr7:91588036 A/G cg01689657 chr7:91764605 CYP51A1 -0.29 -5.32 -0.31 2.24e-7 Breast cancer; CESC cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg24818145 chr4:99064322 C4orf37 0.4 5.05 0.3 8.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11792861 0.926 rs17729523 chr9:111773317 T/C cg05043794 chr9:111880884 C9orf5 -0.41 -6.73 -0.38 1.02e-10 Menarche (age at onset); CESC cis rs8005677 0.828 rs3794452 chr14:23386682 T/G cg01529538 chr14:23388837 RBM23 0.42 5.78 0.33 2.13e-8 Cognitive ability (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16882830 chr7:148823965 ZNF398;ZNF425 0.55 6.17 0.35 2.54e-9 Gut microbiome composition (summer); CESC cis rs2708240 0.577 rs10246256 chr7:147554807 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.39 -5.93 -0.34 9.18e-9 QT interval (drug interaction); CESC trans rs7618501 1.000 rs7431106 chr3:49808374 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.49 0.46 1.51e-15 Intelligence (multi-trait analysis); CESC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg24768116 chr2:27665128 KRTCAP3 0.29 5.21 0.31 3.73e-7 Total body bone mineral density; CESC cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9902453 0.967 rs8082175 chr17:28430303 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 7.99 0.44 4.06e-14 Coffee consumption (cups per day); CESC cis rs11711311 1.000 rs3732793 chr3:113442198 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.31 0.54 3.58e-21 IgG glycosylation; CESC cis rs7772486 0.686 rs1045820 chr6:145947080 C/T cg23711669 chr6:146136114 FBXO30 0.89 13.06 0.63 1.99e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs11122272 0.615 rs1465740 chr1:231495255 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.47 -0.42 1.15e-12 Hemoglobin concentration; CESC cis rs826838 0.967 rs1684414 chr12:39129553 A/G cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs7618915 0.501 rs55678971 chr3:52717229 T/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 5.97 0.34 7.74e-9 Bipolar disorder; CESC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg22968622 chr17:43663579 NA 1.31 17.59 0.73 1.99e-46 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg17372223 chr3:52568218 NT5DC2 0.43 6.39 0.37 7.37e-10 Bipolar disorder; CESC cis rs8141529 0.673 rs132548 chr22:29317559 C/G cg02153584 chr22:29168773 CCDC117 -0.5 -6.46 -0.37 4.97e-10 Lymphocyte counts; CESC cis rs2204008 0.687 rs1733404 chr12:38123395 G/T cg26384229 chr12:38710491 ALG10B -0.68 -9.64 -0.51 4.94e-19 Bladder cancer; CESC trans rs4843747 0.671 rs9921236 chr16:88117015 G/T cg26811252 chr16:29126840 RRN3P2 0.66 8.88 0.48 1.06e-16 Menopause (age at onset); CESC trans rs35110281 0.805 rs2838330 chr21:45023876 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 6.95 0.39 2.77e-11 Mean corpuscular volume; CESC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg18876405 chr7:65276391 NA 0.52 7.03 0.4 1.8e-11 Aortic root size; CESC cis rs9487051 0.604 rs9320282 chr6:109619377 A/G cg01475377 chr6:109611718 NA -0.43 -6.7 -0.38 1.26e-10 Reticulocyte fraction of red cells; CESC cis rs5753618 0.561 rs13054220 chr22:31704492 A/G cg13145458 chr22:31556086 RNF185 -0.52 -5.87 -0.34 1.3e-8 Colorectal cancer; CESC trans rs116095464 0.558 rs28729548 chr5:229025 C/T cg00938859 chr5:1591904 SDHAP3 0.61 6.74 0.38 9.82e-11 Breast cancer; CESC cis rs501120 1.000 rs503859 chr10:44753560 G/C cg09554077 chr10:44749378 NA 0.52 6.89 0.39 3.96e-11 Coronary artery disease;Coronary heart disease; CESC cis rs72945132 0.882 rs6592554 chr11:70226040 G/A cg00319359 chr11:70116639 PPFIA1 0.73 7.1 0.4 1.11e-11 Coronary artery disease; CESC cis rs7208859 0.623 rs216433 chr17:28921860 T/C cg04154034 chr17:28927549 LRRC37B2 0.67 6.02 0.35 5.73e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs585510 1 rs585510 chr12:121000133 A/G cg27279351 chr12:120934652 DYNLL1 0.68 8.85 0.48 1.27e-16 Reticulocyte fraction of red cells; CESC cis rs17376456 0.877 rs55832164 chr5:93436579 C/T cg21475434 chr5:93447410 FAM172A 0.83 7.47 0.42 1.17e-12 Diabetic retinopathy; CESC cis rs12540874 0.500 rs12719030 chr7:50485073 T/C cg18232548 chr7:50535776 DDC -0.4 -5.55 -0.32 6.94e-8 Systemic sclerosis; CESC cis rs9393777 0.588 rs11967935 chr6:26560672 A/C cg12292205 chr6:26970375 C6orf41 -0.44 -5.06 -0.3 7.92e-7 Intelligence (multi-trait analysis); CESC cis rs2486288 0.656 rs8037583 chr15:45546378 A/G cg21132104 chr15:45694354 SPATA5L1 -0.58 -7.1 -0.4 1.12e-11 Glomerular filtration rate; CESC cis rs1707322 0.789 rs7540578 chr1:46252144 C/T cg06784218 chr1:46089804 CCDC17 0.37 6.38 0.37 7.69e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg07211511 chr3:129823064 LOC729375 -0.59 -7.28 -0.41 3.84e-12 Blood pressure (smoking interaction); CESC cis rs2070488 0.965 rs4679060 chr3:38536261 T/C cg24069376 chr3:38537580 EXOG -0.48 -8.93 -0.48 7.12e-17 Electrocardiographic conduction measures; CESC cis rs2522056 1.000 rs2706383 chr5:131792402 G/A cg24060327 chr5:131705240 SLC22A5 0.62 7.16 0.4 7.72e-12 Lymphocyte counts;Fibrinogen; CESC cis rs7824557 0.767 rs2060463 chr8:11161610 T/G cg21775007 chr8:11205619 TDH 0.51 7.5 0.42 9.85e-13 Retinal vascular caliber; CESC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg06634786 chr22:41940651 POLR3H -0.64 -6.62 -0.38 2.02e-10 Vitiligo; CESC cis rs959260 1.000 rs4789189 chr17:73397985 C/G cg12999837 chr17:73267436 MIF4GD -0.52 -5.97 -0.34 7.43e-9 Systemic lupus erythematosus; CESC cis rs6988985 0.560 rs2078674 chr8:143928233 G/T cg10324643 chr8:143916377 GML 0.34 5.08 0.3 7.2e-7 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CESC cis rs796364 0.755 rs6739563 chr2:201134216 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.57 5.27 0.31 2.87e-7 Schizophrenia; CESC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg06481639 chr22:41940642 POLR3H 0.59 5.84 0.34 1.51e-8 Vitiligo; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09135206 chr1:21503313 EIF4G3 -0.42 -6.08 -0.35 4.27e-9 Gambling; CESC cis rs11098499 0.754 rs10006259 chr4:120242145 C/T cg09307838 chr4:120376055 NA 0.79 10.62 0.55 3.51e-22 Corneal astigmatism; CESC cis rs9486719 0.947 rs2499801 chr6:96854594 G/A cg06623918 chr6:96969491 KIAA0776 0.82 7.96 0.44 5.17e-14 Migraine;Coronary artery disease; CESC cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg19539972 chr4:7069911 GRPEL1 0.76 9.56 0.51 8.66e-19 Monocyte percentage of white cells; CESC cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg03433033 chr1:76189801 ACADM -0.66 -7.78 -0.43 1.64e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg04317338 chr11:64019027 PLCB3 0.7 5.94 0.34 8.74e-9 Mean platelet volume; CESC cis rs7772486 0.686 rs9497380 chr6:145955305 T/C cg23711669 chr6:146136114 FBXO30 0.87 12.64 0.61 5.6e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs4925386 0.840 rs6143034 chr20:60920545 T/C cg24112000 chr20:60950667 NA -0.44 -5.47 -0.32 1.03e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC trans rs79976124 0.837 rs10944858 chr6:66646039 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 8.26 0.45 6.99e-15 Type 2 diabetes; CESC cis rs2439831 0.867 rs2412780 chr15:43655794 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.11 0.63 1.34e-30 Lung cancer in ever smokers; CESC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg17143192 chr8:8559678 CLDN23 -0.46 -5.73 -0.33 2.69e-8 Mood instability; CESC cis rs826838 1.000 rs11168367 chr12:38913397 T/G cg26384229 chr12:38710491 ALG10B 0.82 14.44 0.66 2.91e-35 Heart rate; CESC cis rs71403859 0.803 rs10500562 chr16:71627731 A/C cg08717414 chr16:71523259 ZNF19 -0.8 -7.06 -0.4 1.43e-11 Post bronchodilator FEV1; CESC cis rs1348850 0.874 rs4893822 chr2:178285727 G/T cg23306229 chr2:178417860 TTC30B 0.57 6.62 0.38 1.96e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6456156 0.586 rs6456150 chr6:167468922 A/G cg07741184 chr6:167504864 NA 0.36 6.19 0.36 2.29e-9 Primary biliary cholangitis; CESC cis rs9486719 1.000 rs2499807 chr6:96864053 T/G cg18709589 chr6:96969512 KIAA0776 0.52 5.67 0.33 3.8e-8 Migraine;Coronary artery disease; CESC cis rs10089 0.953 rs758180 chr5:127354423 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.77 9.94 0.52 5.42e-20 Ileal carcinoids; CESC cis rs2014572 0.875 rs10405008 chr19:57753643 C/G cg24459738 chr19:57751996 ZNF805 0.49 7.01 0.4 2.03e-11 Hyperactive-impulsive symptoms; CESC cis rs2997447 0.761 rs61776582 chr1:26437262 A/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.51 -6.93 -0.39 3.28e-11 Bipolar disorder; CESC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg00908189 chr16:619842 PIGQ 0.61 8.38 0.46 3.19e-15 Height; CESC cis rs4595586 0.525 rs7972595 chr12:39338000 G/A cg13010199 chr12:38710504 ALG10B 0.46 5.75 0.33 2.49e-8 Morning vs. evening chronotype; CESC trans rs800888 0.865 rs13266941 chr8:116535753 T/C cg19047077 chr12:105044897 CHST11 -0.46 -6.01 -0.35 6.09e-9 Monocyte percentage of white cells; CESC cis rs4722166 0.568 rs1880241 chr7:22759469 A/G cg05472934 chr7:22766657 IL6 0.39 5.39 0.31 1.54e-7 Lung cancer; CESC cis rs1395 0.778 rs4665960 chr2:27467598 C/T cg22903471 chr2:27725779 GCKR -0.42 -5.13 -0.3 5.53e-7 Blood metabolite levels; CESC cis rs12824058 0.831 rs12320318 chr12:130812335 T/C cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs1797081 0.934 rs1797077 chr10:16853252 C/T cg23933602 chr10:16859644 RSU1 1.11 22.74 0.81 3.16e-64 Platelet distribution width; CESC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg08109568 chr15:31115862 NA 0.7 9.32 0.5 4.58e-18 Huntington's disease progression; CESC trans rs4954683 0.735 rs1568880 chr2:141761303 C/A cg04488373 chr7:63385990 NA 0.43 6.03 0.35 5.49e-9 IgG glycosylation; CESC cis rs367615 0.501 rs447849 chr5:108951190 A/C cg17395555 chr5:108820864 NA -0.34 -5.44 -0.32 1.2e-7 Colorectal cancer (SNP x SNP interaction); CESC cis rs1005277 0.522 rs289649 chr10:37975384 T/C cg25427524 chr10:38739819 LOC399744 -0.64 -9.46 -0.5 1.72e-18 Extrinsic epigenetic age acceleration; CESC trans rs853679 0.882 rs3757188 chr6:28107357 T/C cg06606381 chr12:133084897 FBRSL1 -0.67 -6.64 -0.38 1.82e-10 Depression; CESC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg12310025 chr6:25882481 NA -0.5 -7.07 -0.4 1.4e-11 Intelligence (multi-trait analysis); CESC cis rs1538970 0.924 rs7531253 chr1:45890183 T/C cg06784218 chr1:46089804 CCDC17 0.33 5.46 0.32 1.11e-7 Platelet count; CESC cis rs3749237 0.595 rs4955412 chr3:49418168 A/C cg02487422 chr3:49467188 NICN1 0.55 7.99 0.44 4.23e-14 Resting heart rate; CESC cis rs523522 0.962 rs4767903 chr12:120930046 G/A cg12219531 chr12:120966889 COQ5 0.74 9.56 0.51 8.22e-19 High light scatter reticulocyte count; CESC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.84 0.59 2.99e-26 Alzheimer's disease; CESC trans rs656319 0.625 rs4526366 chr8:9890179 C/G cg15556689 chr8:8085844 FLJ10661 -0.58 -6.78 -0.38 8e-11 Myopia (pathological); CESC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -6.86 -0.39 4.94e-11 Personality dimensions; CESC cis rs9915657 0.773 rs9894696 chr17:70099487 C/T cg09344028 chr17:70110421 NA 0.38 7.4 0.41 1.79e-12 Thyroid hormone levels; CESC cis rs11792861 0.926 rs12683988 chr9:111867290 T/C cg05043794 chr9:111880884 C9orf5 -0.42 -6.93 -0.39 3.22e-11 Menarche (age at onset); CESC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg27266027 chr21:40555129 PSMG1 0.49 6.01 0.35 6.14e-9 Cognitive function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13600755 chr15:59499084 LDHAL6B;MYO1E 0.45 6.08 0.35 4.09e-9 Fibrinogen levels; CESC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg11764359 chr7:65958608 NA -0.79 -12.0 -0.59 9.01e-27 Aortic root size; CESC cis rs9287719 0.934 rs6432110 chr2:10738018 T/A cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs67311347 1.000 rs4974017 chr3:40473519 C/T cg24209194 chr3:40518798 ZNF619 0.49 6.52 0.37 3.61e-10 Renal cell carcinoma; CESC cis rs7520050 0.898 rs34175029 chr1:46483871 C/T cg03146154 chr1:46216737 IPP -0.47 -6.05 -0.35 4.92e-9 Red blood cell count;Reticulocyte count; CESC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg22467129 chr15:76604101 ETFA -0.37 -5.67 -0.33 3.81e-8 Blood metabolite levels; CESC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg13206674 chr6:150067644 NUP43 0.42 5.83 0.34 1.61e-8 Lung cancer; CESC cis rs1144333 0.737 rs1144339 chr1:76280543 A/G cg22875332 chr1:76189707 ACADM -0.53 -5.15 -0.3 5.11e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg21770322 chr7:97807741 LMTK2 0.54 8.08 0.44 2.24e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs116095464 0.681 rs1574220 chr5:314518 T/C cg22857025 chr5:266934 NA -1.17 -10.43 -0.54 1.42e-21 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21685218 chr6:143771971 PEX3;ADAT2 -0.46 -6.59 -0.38 2.33e-10 Gambling; CESC cis rs7116495 0.609 rs2276384 chr11:71701523 A/G cg18441811 chr11:71824068 C11orf51 0.79 5.55 0.32 6.77e-8 Severe influenza A (H1N1) infection; CESC cis rs1008375 0.618 rs13129002 chr4:17567513 A/G cg02297831 chr4:17616191 MED28 0.45 5.31 0.31 2.31e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7772486 0.790 rs2814880 chr6:146208937 T/G cg05347473 chr6:146136440 FBXO30 0.55 7.1 0.4 1.15e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg07677032 chr17:61819896 STRADA 0.42 5.38 0.31 1.61e-7 Height; CESC cis rs698833 0.926 rs1067394 chr2:44638123 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 6.62 0.38 2.01e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg06877462 chr1:205807181 PM20D1 0.37 5.26 0.31 3.01e-7 Menarche (age at onset); CESC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.48 0.37 4.53e-10 Bipolar disorder; CESC cis rs1707322 1.000 rs785507 chr1:46541558 C/T cg03146154 chr1:46216737 IPP -0.74 -9.66 -0.51 4.01e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1953600 0.837 rs2236556 chr10:81932790 T/C cg00277334 chr10:82204260 NA 0.46 6.48 0.37 4.47e-10 Sarcoidosis; CESC cis rs72781680 0.898 rs12612492 chr2:24093756 C/T cg08917208 chr2:24149416 ATAD2B 0.98 9.51 0.5 1.25e-18 Lymphocyte counts; CESC cis rs2050392 0.931 rs2265187 chr10:30690844 C/T cg25182066 chr10:30743637 MAP3K8 -0.38 -5.07 -0.3 7.57e-7 Inflammatory bowel disease; CESC cis rs11252926 0.510 rs4881371 chr10:554514 G/A cg16386425 chr10:429943 DIP2C -0.42 -5.34 -0.31 1.97e-7 Psychosis in Alzheimer's disease; CESC cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg02487422 chr3:49467188 NICN1 0.4 5.21 0.3 3.77e-7 Parkinson's disease; CESC cis rs3820068 0.603 rs59558854 chr1:15971399 T/G cg13390004 chr1:15929781 NA 0.36 5.74 0.33 2.61e-8 Systolic blood pressure; CESC trans rs1829883 0.636 rs2968351 chr5:98728753 G/A cg23861655 chr4:57411219 NA 0.39 6.43 0.37 6e-10 Hemostatic factors and hematological phenotypes; CESC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg06028808 chr11:68637592 NA 0.41 5.06 0.3 7.97e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg06221963 chr1:154839813 KCNN3 -0.66 -11.27 -0.57 2.55e-24 Prostate cancer; CESC cis rs72627123 0.656 rs765720 chr14:74541326 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.36 0.31 1.81e-7 Morning vs. evening chronotype; CESC cis rs2228479 0.681 rs4287569 chr16:89957815 A/G cg00800038 chr16:89945340 TCF25 -0.61 -6.89 -0.39 4.14e-11 Skin colour saturation; CESC cis rs7818345 0.967 rs12543061 chr8:19286181 G/T cg11303988 chr8:19266685 CSGALNACT1 -0.35 -6.58 -0.37 2.43e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs10791097 0.694 rs4370948 chr11:130755700 A/C cg12179176 chr11:130786555 SNX19 0.65 10.22 0.53 6.85e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs3540 0.576 rs1974519 chr15:91036460 A/G cg10434728 chr15:90938212 IQGAP1 0.42 7.46 0.42 1.28e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg20503657 chr10:835505 NA 0.65 7.15 0.4 8.29e-12 Eosinophil percentage of granulocytes; CESC trans rs3741489 1.000 rs2306545 chr12:133419296 G/A cg24132527 chr5:140019269 TMCO6 1.1 7.42 0.41 1.61e-12 Cognitive function; CESC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg04234412 chr22:24373322 LOC391322 -0.58 -8.33 -0.46 4.27e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg19077165 chr18:44547161 KATNAL2 -0.62 -9.41 -0.5 2.43e-18 Personality dimensions; CESC cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg02079420 chr8:82753780 SNX16 0.55 8.17 0.45 1.24e-14 Diastolic blood pressure; CESC cis rs3092073 0.624 rs11906879 chr20:44591324 C/T cg17986701 chr20:44574422 PCIF1 -0.35 -5.27 -0.31 2.78e-7 Intelligence (multi-trait analysis); CESC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg18252515 chr7:66147081 NA -0.47 -6.11 -0.35 3.53e-9 Aortic root size; CESC cis rs9902453 0.791 rs2729451 chr17:28131334 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -8.47 -0.46 1.74e-15 Coffee consumption (cups per day); CESC cis rs17125944 1.000 rs17125944 chr14:53400629 C/T cg00686598 chr14:53173677 PSMC6 -0.9 -7.19 -0.4 6.43e-12 Alzheimer's disease (late onset); CESC cis rs3815700 1.000 rs10404211 chr19:33093565 C/T cg02997394 chr19:33096574 ANKRD27 0.66 5.52 0.32 8.23e-8 Eosinophilic esophagitis; CESC cis rs12477438 0.765 rs12468807 chr2:99691994 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs7208859 0.623 rs73269923 chr17:29102571 C/T cg13385521 chr17:29058706 SUZ12P 0.85 6.63 0.38 1.86e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01494614 chr11:10562837 RNF141 0.6 7.32 0.41 2.96e-12 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg03188948 chr7:1209495 NA 0.7 7.05 0.4 1.59e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.4 -0.57 9.17e-25 Type 2 diabetes; CESC cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.64e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs17001868 0.568 rs6001894 chr22:40779197 T/C cg07138101 chr22:40742427 ADSL 0.51 5.15 0.3 5.01e-7 Mammographic density (dense area); CESC cis rs7834588 0.543 rs1455572 chr8:63844564 A/T cg20602954 chr8:63776762 NKAIN3 0.32 5.32 0.31 2.25e-7 Response to Vitamin E supplementation; CESC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.6 0.42 5.05e-13 Tonsillectomy; CESC cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs1034435 0.755 rs5767172 chr22:48892314 A/C cg05992904 chr22:48892994 FAM19A5 -0.57 -9.99 -0.52 3.86e-20 Late-onset Alzheimer's disease; CESC cis rs2354432 0.607 rs2297752 chr1:146765454 C/G cg25205988 chr1:146714368 CHD1L -0.96 -10.35 -0.54 2.56e-21 Mitochondrial DNA levels; CESC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg18402987 chr7:1209562 NA 0.76 7.56 0.42 6.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1050631 0.536 rs1785928 chr18:33725931 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 -0.6 -8.01 -0.44 3.64e-14 Esophageal squamous cell cancer (length of survival); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05221349 chr4:100870488 LOC256880;H2AFZ 0.43 6.5 0.37 3.99e-10 Gut microbiota (bacterial taxa); CESC cis rs9911578 1.000 rs4636974 chr17:56965373 C/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.03 -0.4 1.75e-11 Intelligence (multi-trait analysis); CESC cis rs11630290 0.806 rs11631544 chr15:64098557 A/G cg12036633 chr15:63758958 NA -0.54 -5.2 -0.3 4.01e-7 Iris characteristics; CESC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg05368731 chr17:41323189 NBR1 0.79 10.98 0.56 2.21e-23 Menopause (age at onset); CESC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg18538332 chr22:24372958 LOC391322 0.64 9.06 0.49 2.9e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3820068 0.608 rs12734937 chr1:16047726 T/C cg17385448 chr1:15911702 AGMAT 0.38 5.97 0.34 7.5e-9 Systolic blood pressure; CESC cis rs11677370 0.561 rs12986995 chr2:3826965 G/A cg17052675 chr2:3827356 NA -0.46 -6.01 -0.35 5.96e-9 Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27549887 chr15:48623952 DUT -0.4 -6.11 -0.35 3.63e-9 Gambling; CESC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg27478167 chr7:817139 HEATR2 -0.52 -5.54 -0.32 7.14e-8 Cerebrospinal P-tau181p levels; CESC cis rs6582630 0.502 rs11514371 chr12:38306306 G/C cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs11688816 1.000 rs11688816 chr2:63053048 G/A cg17519650 chr2:63277830 OTX1 -0.47 -6.53 -0.37 3.26e-10 Body mass index; CESC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg17971929 chr21:40555470 PSMG1 1.07 17.1 0.72 1.07e-44 Cognitive function; CESC cis rs6942407 0.545 rs6465101 chr7:86859065 C/G cg02420886 chr7:86849541 C7orf23 0.55 5.14 0.3 5.44e-7 Food allergy; CESC cis rs1371867 0.846 rs1660328 chr8:101303450 A/G cg11906718 chr8:101322791 RNF19A 0.46 5.91 0.34 1.03e-8 Atrioventricular conduction; CESC cis rs6460942 0.597 rs7811374 chr7:12517437 T/C cg20607287 chr7:12443886 VWDE -0.7 -7.58 -0.42 5.83e-13 Coronary artery disease; CESC cis rs67311347 1.000 rs13324109 chr3:40460767 T/C cg24209194 chr3:40518798 ZNF619 0.46 6.03 0.35 5.43e-9 Renal cell carcinoma; CESC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs459571 0.959 rs378740 chr9:136890876 C/A cg13789015 chr9:136890014 NCRNA00094 0.56 7.88 0.44 8.36e-14 Platelet distribution width; CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg01171360 chr6:293285 DUSP22 -0.65 -8.49 -0.46 1.46e-15 Menopause (age at onset); CESC cis rs965513 0.932 rs10818050 chr9:100538923 A/G cg13688889 chr9:100608707 NA -0.56 -8.1 -0.45 2.01e-14 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs2439831 0.702 rs7175032 chr15:44060236 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.71 8.09 0.45 2.1e-14 Lung cancer in ever smokers; CESC cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg15605315 chr1:45957053 TESK2 0.5 6.64 0.38 1.76e-10 High light scatter reticulocyte count; CESC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg03351412 chr1:154909251 PMVK 0.69 9.38 0.5 3.14e-18 Prostate cancer; CESC cis rs1949733 0.675 rs2688235 chr4:8450546 T/C cg11789530 chr4:8429930 ACOX3 0.76 10.94 0.56 3.06e-23 Response to antineoplastic agents; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg25001845 chr14:75201709 FCF1 -0.46 -6.24 -0.36 1.75e-9 Breast cancer;Type 2 diabetes; CESC cis rs2841277 0.676 rs10438247 chr14:105411781 G/A cg21017887 chr14:105400489 NA 0.42 6.94 0.39 3e-11 Rheumatoid arthritis; CESC cis rs2898681 0.561 rs6855240 chr4:53740787 G/A cg00791764 chr4:53727839 RASL11B 0.54 5.37 0.31 1.7e-7 Optic nerve measurement (cup area); CESC cis rs57221529 0.766 rs12521051 chr5:560440 A/G cg09021430 chr5:549028 NA 0.4 5.19 0.3 4.19e-7 Lung disease severity in cystic fibrosis; CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg12963246 chr6:28129442 ZNF389 0.6 8.28 0.45 5.95e-15 Depression; CESC cis rs2290720 0.965 rs703713 chr12:101682211 A/G cg22051763 chr12:101673672 UTP20 0.48 5.66 0.33 3.88e-8 Brain structure (hippocampal volume); CESC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg00129232 chr17:37814104 STARD3 -0.57 -7.33 -0.41 2.77e-12 Glomerular filtration rate (creatinine); CESC cis rs6547741 0.844 rs7586655 chr2:27915659 A/G cg27432699 chr2:27873401 GPN1 -0.59 -8.72 -0.47 3.22e-16 Oral cavity cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13633529 chr15:101141955 ASB7;LINS1 0.46 6.6 0.38 2.22e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg18357526 chr6:26021779 HIST1H4A 0.59 7.98 0.44 4.36e-14 Intelligence (multi-trait analysis); CESC cis rs7647973 0.588 rs9883000 chr3:49667691 A/G cg13072238 chr3:49761600 GMPPB -0.45 -5.4 -0.31 1.51e-7 Menarche (age at onset); CESC cis rs9486719 1.000 rs12190397 chr6:97036465 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -8.21 -0.45 9.56e-15 Migraine;Coronary artery disease; CESC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg05234568 chr11:5960015 NA -0.65 -8.98 -0.48 5.17e-17 DNA methylation (variation); CESC cis rs4629710 0.545 rs11154621 chr6:131547341 A/G cg12606694 chr6:131520996 AKAP7 0.42 5.47 0.32 1.05e-7 Multiple myeloma (IgH translocation); CESC cis rs12971120 0.891 rs12605820 chr18:72167802 G/A cg25817165 chr18:72167213 CNDP2 -0.58 -7.09 -0.4 1.24e-11 Refractive error; CESC cis rs9486719 0.857 rs11751075 chr6:97065751 G/A cg18709589 chr6:96969512 KIAA0776 -0.49 -5.45 -0.32 1.14e-7 Migraine;Coronary artery disease; CESC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg19163074 chr7:65112434 INTS4L2 -0.41 -5.11 -0.3 6.29e-7 Aortic root size; CESC cis rs11997175 1.000 rs10453046 chr8:33773179 T/C ch.8.33884649F chr8:33765107 NA 0.63 8.08 0.44 2.24e-14 Body mass index; CESC cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg06697600 chr4:7070879 GRPEL1 -0.49 -6.97 -0.39 2.45e-11 Monocyte percentage of white cells; CESC cis rs4330281 0.740 rs4643736 chr3:17792256 G/T cg20981856 chr3:17787350 NA 0.36 5.08 0.3 7.15e-7 Schizophrenia; CESC cis rs9443189 0.570 rs485906 chr6:76300550 A/C cg01950844 chr6:76311363 SENP6 0.87 9.54 0.51 9.61e-19 Prostate cancer; CESC cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg11764359 chr7:65958608 NA 0.79 9.05 0.49 3.06e-17 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10787120 chr14:96857745 AK7 0.58 6.32 0.36 1.11e-9 Gut microbiome composition (summer); CESC cis rs597583 0.664 rs10892133 chr11:117383694 C/T cg27161313 chr11:117392002 DSCAML1 -0.49 -5.99 -0.35 6.96e-9 Putamen volume; CESC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg16425592 chr11:842748 TSPAN4;POLR2L -0.78 -11.0 -0.56 1.92e-23 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03902233 chr6:122792987 PKIB;SERINC1 0.56 6.49 0.37 4.29e-10 Gut microbiome composition (summer); CESC cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.5 0.37 4.05e-10 Eosinophil percentage of white cells; CESC cis rs6087771 0.682 rs2038397 chr20:30217759 A/G cg13852791 chr20:30311386 BCL2L1 0.67 7.77 0.43 1.7e-13 Subcortical brain region volumes;Putamen volume; CESC cis rs735396 0.595 rs2258287 chr12:121454313 G/T cg02403541 chr12:121454288 C12orf43 0.8 11.98 0.59 9.82e-27 N-glycan levels; CESC cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.32 -5.18 -0.3 4.35e-7 Hemoglobin concentration; CESC cis rs9916302 0.904 rs3744348 chr17:37417575 C/G cg20243544 chr17:37824526 PNMT 0.47 5.8 0.34 1.85e-8 Glomerular filtration rate (creatinine); CESC cis rs3733585 0.699 rs12498150 chr4:9950537 C/T cg11266682 chr4:10021025 SLC2A9 -0.58 -11.18 -0.57 4.91e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg20887711 chr4:1340912 KIAA1530 0.89 11.78 0.59 4.87e-26 Longevity; CESC cis rs929596 0.639 rs7571915 chr2:234586574 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -5.76 -0.33 2.28e-8 Total bilirubin levels in HIV-1 infection; CESC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg06028605 chr16:24865363 SLC5A11 0.51 7.47 0.42 1.14e-12 Intelligence (multi-trait analysis); CESC cis rs708547 0.599 rs1718864 chr4:57887471 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.48 6.68 0.38 1.38e-10 Response to bleomycin (chromatid breaks); CESC cis rs4911259 0.552 rs13042651 chr20:31467423 C/T cg13636640 chr20:31349939 DNMT3B -0.54 -7.44 -0.42 1.45e-12 Inflammatory bowel disease; CESC cis rs2635047 0.684 rs7236105 chr18:44757226 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.51 0.32 8.53e-8 Educational attainment; CESC cis rs965469 0.779 rs2207995 chr20:3294484 T/C cg25506879 chr20:3388711 C20orf194 -0.48 -5.35 -0.31 1.92e-7 IFN-related cytopenia; CESC cis rs4450131 0.522 rs876352 chr10:126337350 C/T cg20435097 chr10:126320824 FAM53B 0.29 5.21 0.3 3.84e-7 White blood cell count (basophil); CESC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg11644478 chr21:40555479 PSMG1 -0.83 -12.81 -0.62 1.5e-29 Cognitive function; CESC cis rs2075371 0.932 rs1862052 chr7:133981227 G/A cg11752832 chr7:134001865 SLC35B4 0.52 6.74 0.38 9.65e-11 Mean platelet volume; CESC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg04414720 chr1:150670196 GOLPH3L 0.45 5.9 0.34 1.12e-8 Melanoma; CESC cis rs9814567 1.000 rs17694011 chr3:134213981 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.99 -0.35 6.9e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg18876405 chr7:65276391 NA -0.53 -7.25 -0.41 4.64e-12 Aortic root size; CESC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg24503407 chr1:205819492 PM20D1 0.66 10.86 0.56 5.52e-23 Monocyte percentage of white cells; CESC cis rs752010 0.530 rs10789401 chr1:42081111 A/G cg06885757 chr1:42089581 HIVEP3 0.7 11.21 0.57 3.92e-24 Lupus nephritis in systemic lupus erythematosus; CESC cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg17366294 chr4:99064904 C4orf37 0.56 7.62 0.42 4.5e-13 Colonoscopy-negative controls vs population controls; CESC cis rs3796619 1.000 rs11247973 chr4:1094314 G/A cg27284194 chr4:1044797 NA 0.37 5.59 0.32 5.6e-8 Recombination rate (males); CESC cis rs9457247 1.000 rs430097 chr6:167405073 A/G cg23791538 chr6:167370224 RNASET2 -0.59 -8.42 -0.46 2.44e-15 Crohn's disease; CESC cis rs796364 0.664 rs4673660 chr2:200915395 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.7 7.24 0.41 5.01e-12 Schizophrenia; CESC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg01416388 chr22:39784598 NA 0.5 6.05 0.35 4.9e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7095944 0.583 rs12218394 chr10:126480591 G/C cg08799069 chr10:126477246 METTL10 -0.4 -5.79 -0.34 1.97e-8 Asthma; CESC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg18876405 chr7:65276391 NA -0.5 -5.87 -0.34 1.28e-8 Aortic root size; CESC cis rs763014 1.000 rs763014 chr16:675680 T/C cg07343612 chr16:622815 PIGQ -0.56 -8.21 -0.45 9.95e-15 Height; CESC cis rs6062788 0.524 rs6122362 chr20:61701245 C/T cg20652954 chr20:61716293 NA -0.32 -5.34 -0.31 1.96e-7 Body mass index; CESC cis rs3820068 0.553 rs7545782 chr1:15955227 G/C cg17385448 chr1:15911702 AGMAT 0.43 6.93 0.39 3.22e-11 Systolic blood pressure; CESC cis rs1499614 0.901 rs3936 chr7:66126489 C/T cg13147721 chr7:65941812 NA -0.93 -8.6 -0.47 7.11e-16 Gout; CESC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.92 -0.52 6.14e-20 Developmental language disorder (linguistic errors); CESC cis rs523522 0.962 rs12371550 chr12:120987643 C/T cg27279351 chr12:120934652 DYNLL1 0.68 8.94 0.48 6.97e-17 High light scatter reticulocyte count; CESC cis rs5758659 0.714 rs5758574 chr22:42481400 G/C cg00645731 chr22:42541494 CYP2D7P1 0.32 5.59 0.32 5.67e-8 Cognitive function; CESC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.51e-24 Menopause (age at onset); CESC cis rs17401966 1.000 rs12141416 chr1:10327867 A/G cg15208524 chr1:10270712 KIF1B 0.41 5.29 0.31 2.61e-7 Hepatocellular carcinoma; CESC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg20307385 chr11:47447363 PSMC3 0.62 7.61 0.42 4.7e-13 Subjective well-being; CESC cis rs7834588 0.523 rs1455576 chr8:63822440 C/T cg20602954 chr8:63776762 NKAIN3 -0.31 -5.3 -0.31 2.45e-7 Response to Vitamin E supplementation; CESC cis rs17431357 1.000 rs117894641 chr12:120939099 T/C cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs17376456 1.000 rs59472588 chr5:93511981 A/G cg25358565 chr5:93447407 FAM172A 1.16 11.62 0.58 1.67e-25 Diabetic retinopathy; CESC trans rs11989744 0.500 rs7826517 chr8:23568841 G/A cg03492747 chr16:86543808 FOXF1 -0.84 -13.4 -0.64 1.32e-31 Waist-hip ratio; CESC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg00908189 chr16:619842 PIGQ 0.63 8.84 0.48 1.33e-16 Height; CESC cis rs80282103 0.618 rs12250141 chr10:1160106 A/T cg08668510 chr10:1095578 IDI1 0.88 5.57 0.32 6.15e-8 Glomerular filtration rate (creatinine); CESC cis rs722599 0.651 rs7159354 chr14:75253847 A/G cg08847533 chr14:75593920 NEK9 0.45 5.58 0.32 5.85e-8 IgG glycosylation; CESC cis rs9354308 0.677 rs9363462 chr6:66557612 A/T cg07460842 chr6:66804631 NA -0.42 -5.07 -0.3 7.32e-7 Metabolite levels; CESC cis rs9987353 0.522 rs2929466 chr8:9063899 G/T cg06636001 chr8:8085503 FLJ10661 -0.42 -5.12 -0.3 6.02e-7 Recombination measurement; CESC cis rs6456156 0.586 rs13210649 chr6:167473193 T/G cg23791538 chr6:167370224 RNASET2 -0.52 -6.7 -0.38 1.24e-10 Primary biliary cholangitis; CESC cis rs2760061 0.819 rs1745417 chr1:228204279 C/T cg02753203 chr1:228287806 NA 0.53 7.87 0.44 9.03e-14 Diastolic blood pressure; CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg05064044 chr6:292385 DUSP22 0.68 8.74 0.47 2.71e-16 Menopause (age at onset); CESC cis rs9549367 0.713 rs2146750 chr13:113822530 A/G cg18105134 chr13:113819100 PROZ 0.6 7.07 0.4 1.37e-11 Platelet distribution width; CESC cis rs561341 1.000 rs530715 chr17:30320544 T/G cg00745463 chr17:30367425 LRRC37B -0.69 -7.02 -0.4 1.88e-11 Hip circumference adjusted for BMI; CESC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg07157834 chr1:205819609 PM20D1 0.73 10.77 0.55 1.16e-22 Menarche (age at onset); CESC cis rs798943 0.806 rs10242653 chr7:120865801 C/A cg09857513 chr7:120969044 WNT16 0.3 5.04 0.3 8.74e-7 Bone mineral density (paediatric, upper limb); CESC cis rs9916302 0.706 rs9908131 chr17:37520449 T/C cg07936489 chr17:37558343 FBXL20 0.9 9.75 0.51 2.09e-19 Glomerular filtration rate (creatinine); CESC cis rs34779708 0.931 rs79749947 chr10:35277081 A/T cg03585969 chr10:35415529 CREM 0.77 10.16 0.53 1.05e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs8077889 0.871 rs17675370 chr17:41900030 T/C cg26893861 chr17:41843967 DUSP3 0.83 9.86 0.52 9.44e-20 Triglycerides; CESC cis rs1045714 0.895 rs4719594 chr7:2639790 G/A cg20813462 chr7:2646259 IQCE 0.65 5.61 0.33 5.2e-8 Urate levels in lean individuals; CESC cis rs709400 0.859 rs7693 chr14:104023704 C/T cg24130564 chr14:104152367 KLC1 -0.43 -5.23 -0.31 3.5e-7 Body mass index; CESC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg05863683 chr7:1912471 MAD1L1 0.38 5.48 0.32 1.01e-7 Schizophrenia; CESC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg17372223 chr3:52568218 NT5DC2 0.48 7.6 0.42 5.21e-13 Electroencephalogram traits; CESC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg22433210 chr17:43662623 NA -0.91 -10.51 -0.54 7.86e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs796364 0.806 rs203769 chr2:200900866 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.84 -7.93 -0.44 6.25e-14 Schizophrenia; CESC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg24060327 chr5:131705240 SLC22A5 -0.73 -10.01 -0.52 3.26e-20 Breast cancer; CESC cis rs561341 1.000 rs56903735 chr17:30254393 T/A cg19193384 chr17:30244184 NA -0.61 -6.35 -0.36 9.48e-10 Hip circumference adjusted for BMI; CESC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs116095464 0.614 rs62344292 chr5:244630 G/A cg10591111 chr5:226296 SDHA -0.52 -6.38 -0.36 7.94e-10 Breast cancer; CESC cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg13298116 chr11:62369859 EML3;MTA2 0.66 9.78 0.51 1.8e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs796364 0.950 rs56155997 chr2:200768491 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.83 -6.37 -0.36 8.12e-10 Schizophrenia; CESC cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg22590775 chr19:49891494 CCDC155 0.45 5.04 0.3 8.62e-7 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02896403 chr1:155231989 SCAMP3 0.6 6.69 0.38 1.34e-10 Gut microbiome composition (summer); CESC cis rs11718455 1.000 rs4682928 chr3:44037192 T/C cg08738300 chr3:44038990 NA 0.48 6.41 0.37 6.74e-10 Coronary artery disease; CESC cis rs524023 0.957 rs538737 chr11:64355772 C/G cg07220939 chr11:64358617 SLC22A12 0.36 5.6 0.33 5.43e-8 Urate levels in obese individuals; CESC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg18446336 chr7:2847575 GNA12 -0.36 -5.49 -0.32 9.34e-8 Height; CESC cis rs2637266 0.756 rs2583063 chr10:78558048 T/C cg18941641 chr10:78392320 NA 0.41 7.83 0.43 1.17e-13 Pulmonary function; CESC cis rs2072732 0.861 rs12041583 chr1:2950886 A/G cg15211996 chr1:2936768 ACTRT2 0.34 5.95 0.34 8.31e-9 Plateletcrit; CESC cis rs8017423 0.647 rs4900037 chr14:90821478 A/G cg14092571 chr14:90743983 NA -0.42 -6.44 -0.37 5.66e-10 Mortality in heart failure; CESC cis rs12681366 0.537 rs2919659 chr8:95471772 T/C cg13257157 chr8:95487014 RAD54B 0.45 5.44 0.32 1.23e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC cis rs1499972 0.941 rs62264819 chr3:117671941 T/C cg07612923 chr3:117604196 NA 0.89 7.41 0.41 1.71e-12 Schizophrenia; CESC cis rs9487051 0.676 rs9400268 chr6:109600550 C/T cg12927641 chr6:109611667 NA -0.36 -5.49 -0.32 9.3e-8 Reticulocyte fraction of red cells; CESC cis rs17401966 0.931 rs2185252 chr1:10415912 T/C cg15208524 chr1:10270712 KIF1B 0.41 5.18 0.3 4.35e-7 Hepatocellular carcinoma; CESC cis rs2273669 0.667 rs78714994 chr6:109350351 G/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07849438 chr12:19593035 AEBP2 0.56 6.45 0.37 5.22e-10 Gut microbiome composition (summer); CESC cis rs3741151 1.000 rs1892856 chr11:73017971 G/C cg17517138 chr11:73019481 ARHGEF17 1.13 7.47 0.42 1.15e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs4523957 0.583 rs4349181 chr17:2040963 A/G cg16513277 chr17:2031491 SMG6 -0.76 -11.08 -0.56 1.09e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg19193384 chr17:30244184 NA -0.56 -5.99 -0.35 6.81e-9 Hip circumference adjusted for BMI; CESC cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg23649088 chr2:200775458 C2orf69 -0.55 -5.41 -0.32 1.39e-7 Schizophrenia; CESC cis rs9457247 1.000 rs385113 chr6:167403971 A/G cg23791538 chr6:167370224 RNASET2 -0.59 -8.42 -0.46 2.44e-15 Crohn's disease; CESC cis rs2302190 0.882 rs11656888 chr17:56546725 T/A cg25885038 chr17:56607967 SEPT4 -0.41 -5.58 -0.32 5.79e-8 Vitamin D levels; CESC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg20295408 chr7:1910781 MAD1L1 -0.44 -5.8 -0.34 1.91e-8 Bipolar disorder and schizophrenia; CESC cis rs6430585 0.583 rs58509842 chr2:136586027 G/A cg07169764 chr2:136633963 MCM6 1.28 18.2 0.75 1.4e-48 Corneal structure; CESC trans rs3925158 0.510 rs4955394 chr3:38293463 C/G cg23247845 chr10:3679085 NA 0.66 6.06 0.35 4.74e-9 Gut microbiota (bacterial taxa); CESC cis rs3733585 0.773 rs13107466 chr4:10019390 G/A cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.14e-46 Cleft plate (environmental tobacco smoke interaction); CESC cis rs5758511 0.680 rs5758684 chr22:42649509 C/T cg00645731 chr22:42541494 CYP2D7P1 0.58 8.64 0.47 5.58e-16 Birth weight; CESC cis rs2066819 1.000 rs79436528 chr12:56686997 C/T cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.65e-39 Menopause (age at onset); CESC cis rs763121 0.853 rs1065201 chr22:39069510 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg25036284 chr2:26402008 FAM59B 0.68 7.36 0.41 2.38e-12 Gut microbiome composition (summer); CESC cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg11752832 chr7:134001865 SLC35B4 0.54 7.02 0.4 1.91e-11 Mean platelet volume; CESC cis rs2425143 1.000 rs113203744 chr20:34253656 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.14 0.3 5.43e-7 Blood protein levels; CESC cis rs4766566 0.501 rs3742004 chr12:111798553 A/G cg10833066 chr12:111807467 FAM109A 0.34 5.22 0.31 3.69e-7 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; CESC cis rs5995756 0.736 rs1883123 chr22:39996882 C/T cg03390717 chr22:39966585 CACNA1I -0.31 -5.4 -0.31 1.46e-7 Autism spectrum disorder or schizophrenia; CESC trans rs11098499 0.722 rs28713555 chr4:120251995 C/T cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs9660992 0.573 rs1318187 chr1:205206172 T/A cg00857998 chr1:205179979 DSTYK 0.56 6.88 0.39 4.29e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs7020830 0.858 rs7856690 chr9:37127545 A/T cg14294708 chr9:37120828 ZCCHC7 1.11 20.06 0.78 4.3e-55 Schizophrenia; CESC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg07701084 chr6:150067640 NUP43 0.45 6.27 0.36 1.45e-9 Lung cancer; CESC trans rs8026198 0.568 rs1678984 chr15:42616332 T/G cg11538410 chr8:142141455 DENND3 0.61 6.04 0.35 5.32e-9 Fibrinogen levels; CESC cis rs854765 0.583 rs8065970 chr17:17858771 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg06873352 chr17:61820015 STRADA 0.72 12.61 0.61 7.18e-29 Prudent dietary pattern; CESC cis rs12477438 0.520 rs11689265 chr2:99799267 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.11 0.68 1.23e-37 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11658038 chr5:141303204 KIAA0141 0.53 6.03 0.35 5.39e-9 Gut microbiome composition (summer); CESC trans rs7307889 0.793 rs59382088 chr12:5995398 G/A cg18407955 chr7:158110685 PTPRN2 -0.72 -6.18 -0.35 2.39e-9 Obesity-related traits; CESC cis rs6493487 0.512 rs1438926 chr15:51351145 G/T cg02338191 chr15:51200825 AP4E1 0.58 5.42 0.32 1.31e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.11 -0.3 6.13e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs55871839 0.708 rs2326213 chr8:59812459 A/G cg07426533 chr8:59803705 TOX -0.47 -7.01 -0.4 1.95e-11 Pneumonia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09571097 chr17:899782 TIMM22 -0.61 -7.43 -0.42 1.54e-12 Gut microbiome composition (summer); CESC cis rs61931739 0.500 rs7310576 chr12:34474735 T/C cg23762105 chr12:34175262 ALG10 -0.39 -5.05 -0.3 8.28e-7 Morning vs. evening chronotype; CESC cis rs1499972 0.938 rs861673 chr3:117733019 A/G cg07612923 chr3:117604196 NA -0.78 -6.32 -0.36 1.08e-9 Schizophrenia; CESC cis rs2439831 0.867 rs45585139 chr15:43700427 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.77 8.68 0.47 4.05e-16 Lung cancer in ever smokers; CESC cis rs7937682 0.924 rs12791699 chr11:111505880 T/C cg09085632 chr11:111637200 PPP2R1B -0.99 -16.01 -0.7 8.36e-41 Primary sclerosing cholangitis; CESC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.8 0.39 6.78e-11 Bipolar disorder; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15084499 chr1:227505916 CDC42BPA 0.46 6.67 0.38 1.52e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg05313129 chr8:58192883 C8orf71 -0.51 -5.98 -0.34 7.31e-9 Developmental language disorder (linguistic errors); CESC cis rs77741769 0.571 rs3883901 chr12:121256520 A/G cg02419362 chr12:121203948 SPPL3 0.34 5.57 0.32 6.14e-8 Mean corpuscular volume; CESC cis rs12477438 0.520 rs1453563 chr2:99720267 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 12.89 0.62 7.58e-30 Chronic sinus infection; CESC cis rs965469 0.779 rs6037516 chr20:3233142 C/G cg25506879 chr20:3388711 C20orf194 -0.51 -5.57 -0.32 6.1e-8 IFN-related cytopenia; CESC cis rs10178409 1 rs10178409 chr2:73855507 G/T cg20560298 chr2:73613845 ALMS1 -0.42 -5.08 -0.3 7.04e-7 Urinary metabolites; CESC cis rs3762637 0.943 rs9872708 chr3:122242807 C/G cg24169773 chr3:122142474 KPNA1 -0.59 -6.94 -0.39 3.01e-11 LDL cholesterol levels; CESC cis rs6460942 0.597 rs6968664 chr7:12515493 T/C cg20607287 chr7:12443886 VWDE -0.63 -7.11 -0.4 1.1e-11 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05062854 chr22:32435553 NA 0.43 6.65 0.38 1.67e-10 Gambling; CESC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg08888203 chr3:10149979 C3orf24 0.5 6.17 0.35 2.58e-9 Alzheimer's disease; CESC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs4243830 0.571 rs60256927 chr1:6614747 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.95 9.29 0.5 5.77e-18 Body mass index; CESC trans rs6582630 0.634 rs10748443 chr12:38734062 G/T cg23762105 chr12:34175262 ALG10 -0.45 -6.01 -0.35 5.97e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs17253792 0.732 rs28380739 chr14:56088402 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs14403 1.000 rs9803713 chr1:243672000 C/G cg21452805 chr1:244014465 NA 0.49 5.47 0.32 1.04e-7 Schizophrenia; CESC cis rs1707322 0.691 rs11211174 chr1:46220816 C/G cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg00166722 chr3:10149974 C3orf24 0.53 6.65 0.38 1.64e-10 Alzheimer's disease; CESC cis rs9309473 1.000 rs1881245 chr2:73649928 G/A cg20560298 chr2:73613845 ALMS1 -0.5 -6.81 -0.39 6.38e-11 Metabolite levels; CESC trans rs17685 0.672 rs55807301 chr7:75807401 C/A cg19862616 chr7:65841803 NCRNA00174 0.82 11.72 0.58 7.99e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs10911232 0.507 rs3935384 chr1:183028970 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 13.58 0.64 3.12e-32 Hypertriglyceridemia; CESC cis rs6459788 0.502 rs9692347 chr7:157232659 C/T cg03453431 chr7:157225567 NA -0.41 -6.99 -0.39 2.19e-11 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs362272 0.545 rs2748447 chr4:3337831 G/A cg08886695 chr4:3369023 RGS12 -0.41 -5.6 -0.33 5.29e-8 Serum sulfate level; CESC cis rs2337406 0.714 rs8022729 chr14:107225161 C/T cg07958169 chr14:107095056 NA 0.49 5.6 0.33 5.37e-8 Alzheimer's disease (late onset); CESC cis rs2764980 1.000 rs2764979 chr10:3283882 T/C cg11630169 chr10:3283847 NA -0.37 -5.13 -0.3 5.54e-7 Attention deficit hyperactivity disorder and conduct disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01034784 chr2:95831832 ZNF2 -0.64 -7.76 -0.43 1.8e-13 Gut microbiome composition (summer); CESC cis rs2806561 0.765 rs2806565 chr1:23507068 A/G cg12483005 chr1:23474871 LUZP1 0.39 6.15 0.35 2.85e-9 Height; CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg19592336 chr6:28129416 ZNF389 0.63 8.61 0.47 6.75e-16 Depression; CESC cis rs28374715 0.578 rs8036026 chr15:41630499 C/G cg20272979 chr15:41787780 ITPKA 0.46 5.41 0.32 1.41e-7 Ulcerative colitis; CESC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.65 0.38 1.63e-10 Bipolar disorder; CESC cis rs2120019 1.000 rs12901243 chr15:75374233 C/T cg17294928 chr15:75287854 SCAMP5 -0.59 -6.65 -0.38 1.64e-10 Blood trace element (Zn levels); CESC cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg10578991 chr7:12443926 VWDE -0.43 -5.59 -0.32 5.71e-8 Coronary artery disease; CESC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg08470875 chr2:26401718 FAM59B -0.47 -5.22 -0.31 3.6e-7 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg03188948 chr7:1209495 NA 0.73 7.02 0.4 1.85e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8062405 1.000 rs72793812 chr16:28840381 A/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.36 -0.31 1.85e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9894429 0.966 rs6565605 chr17:79589359 C/T cg18240062 chr17:79603768 NPLOC4 0.7 9.81 0.52 1.35e-19 Eye color traits; CESC cis rs11122272 0.670 rs2474632 chr1:231484361 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -7.34 -0.41 2.63e-12 Hemoglobin concentration; CESC cis rs2228479 0.850 rs1800344 chr16:89816367 T/G cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs2415984 0.622 rs1761026 chr14:46930139 T/C cg14871534 chr14:47121158 RPL10L 0.36 5.52 0.32 7.98e-8 Number of children ever born; CESC cis rs11098499 0.863 rs2306456 chr4:120472422 C/G cg24375607 chr4:120327624 NA 0.45 5.54 0.32 7.33e-8 Corneal astigmatism; CESC cis rs1707322 0.721 rs12045096 chr1:46114428 A/G cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7072216 0.763 rs2274245 chr10:100175082 C/T cg26618903 chr10:100175079 PYROXD2 -0.38 -5.9 -0.34 1.11e-8 Metabolite levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07264050 chr8:48920858 UBE2V2 -0.39 -6.09 -0.35 3.98e-9 Gambling; CESC cis rs11677370 0.561 rs10084170 chr2:3820204 G/C cg17052675 chr2:3827356 NA -0.44 -5.86 -0.34 1.34e-8 Type 2 diabetes; CESC cis rs6460942 0.597 rs17448193 chr7:12525641 G/A cg10578991 chr7:12443926 VWDE -0.49 -5.13 -0.3 5.63e-7 Coronary artery disease; CESC cis rs4233366 0.959 rs2070901 chr1:161185058 G/T cg13853198 chr1:161185092 FCER1G 0.42 6.56 0.37 2.88e-10 Asthma; CESC cis rs12477438 0.520 rs4402818 chr2:99717608 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.93 16.07 0.7 5.04e-41 Chronic sinus infection; CESC cis rs12442242 0.522 rs16966212 chr15:38360289 T/C cg19084031 chr15:38361362 NA 0.96 6.56 0.37 2.83e-10 Total body bone mineral density; CESC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg18876405 chr7:65276391 NA -0.57 -7.53 -0.42 7.86e-13 Aortic root size; CESC cis rs427394 0.582 rs274661 chr5:6704848 C/T cg10857441 chr5:6722123 POLS -0.42 -5.07 -0.3 7.61e-7 Menopause (age at onset); CESC trans rs61931739 0.517 rs1843737 chr12:34015305 A/G cg26384229 chr12:38710491 ALG10B 0.45 6.33 0.36 1.02e-9 Morning vs. evening chronotype; CESC cis rs863345 0.604 rs10797021 chr1:158490341 T/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC cis rs9527 0.590 rs7910900 chr10:104829898 C/T cg04362960 chr10:104952993 NT5C2 0.42 5.26 0.31 2.98e-7 Arsenic metabolism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03818826 chr16:70323689 AARS -0.57 -6.74 -0.38 9.83e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22841110 chr11:64053472 BAD;GPR137 0.54 6.17 0.35 2.5e-9 Gut microbiome composition (summer); CESC cis rs10861342 1.000 rs12229846 chr12:105553066 A/C cg23923672 chr12:105501055 KIAA1033 0.66 5.44 0.32 1.21e-7 IgG glycosylation; CESC cis rs4604732 0.631 rs56704806 chr1:247626148 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs28602670 1 rs28602670 chr15:78768167 C/G cg24631222 chr15:78858424 CHRNA5 0.65 7.69 0.43 2.83e-13 Post bronchodilator FEV1; CESC trans rs60380162 0.963 rs11579302 chr1:87730211 T/G cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.03 -0.35 5.48e-9 Loneliness (linear analysis); CESC cis rs3096299 0.866 rs4238829 chr16:89462262 G/A cg02187348 chr16:89574699 SPG7 0.51 6.75 0.38 9.37e-11 Multiple myeloma (IgH translocation); CESC cis rs10743315 0.778 rs965861 chr12:19360719 A/G cg02471346 chr12:19282374 PLEKHA5 -0.48 -5.16 -0.3 4.87e-7 Gut microbiota (bacterial taxa); CESC cis rs4737010 0.530 rs4026 chr8:41645710 C/T cg08923054 chr8:41654455 ANK1 0.53 6.71 0.38 1.16e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg04369109 chr6:150039330 LATS1 -0.4 -5.54 -0.32 7.28e-8 Lung cancer; CESC trans rs208520 0.690 rs1100981 chr6:66852052 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.93 -0.62 5.39e-30 Exhaled nitric oxide output; CESC trans rs1814175 0.645 rs847635 chr11:49923323 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs7649275 0.882 rs2612024 chr3:53779580 G/C cg21503701 chr3:53781065 CACNA1D -0.4 -5.28 -0.31 2.66e-7 Trans fatty acid levels; CESC cis rs6445797 0.632 rs2004199 chr3:56645866 A/G cg13792233 chr3:56591045 CCDC66 -0.4 -5.31 -0.31 2.28e-7 Gastritis; CESC cis rs7845219 0.544 rs7016078 chr8:95922615 G/A cg13393036 chr8:95962371 TP53INP1 -0.43 -8.22 -0.45 9.43e-15 Type 2 diabetes; CESC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg26314531 chr2:26401878 FAM59B 0.8 8.22 0.45 9.18e-15 Gut microbiome composition (summer); CESC cis rs4561483 0.771 rs7202234 chr16:11942322 A/G cg08843971 chr16:11963173 GSPT1 0.49 7.15 0.4 8.44e-12 Testicular germ cell tumor; CESC cis rs6087990 0.806 rs2424918 chr20:31382770 C/T cg13636640 chr20:31349939 DNMT3B 0.82 13.25 0.63 4.5e-31 Ulcerative colitis; CESC cis rs7551222 0.752 rs10900597 chr1:204522489 C/T cg20240347 chr1:204465584 NA -0.28 -5.62 -0.33 4.73e-8 Schizophrenia; CESC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg18032046 chr6:28092343 ZSCAN16 -0.47 -6.14 -0.35 2.93e-9 Cardiac Troponin-T levels; CESC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg07936489 chr17:37558343 FBXL20 -0.8 -11.2 -0.57 4.38e-24 Glomerular filtration rate (creatinine); CESC cis rs116095464 0.558 rs6882584 chr5:223411 A/C cg22857025 chr5:266934 NA -1.27 -18.89 -0.76 5.51e-51 Breast cancer; CESC cis rs7020830 0.898 rs7846747 chr9:37167539 A/C cg14294708 chr9:37120828 ZCCHC7 1.23 23.92 0.83 3.7e-68 Schizophrenia; CESC cis rs2228479 0.681 rs3212346 chr16:89982358 G/A cg04287289 chr16:89883240 FANCA 0.55 5.18 0.3 4.49e-7 Skin colour saturation; CESC cis rs2050392 0.517 rs656600 chr10:30765654 G/A cg25182066 chr10:30743637 MAP3K8 -0.52 -7.65 -0.43 3.64e-13 Inflammatory bowel disease; CESC trans rs7618501 0.699 rs2777888 chr3:49898000 A/G cg21659725 chr3:3221576 CRBN 0.59 8.31 0.45 5.04e-15 Intelligence (multi-trait analysis); CESC cis rs1707322 1.000 rs6695421 chr1:46380207 T/C cg05343316 chr1:45956843 TESK2 0.45 5.55 0.32 6.79e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10751667 0.643 rs6597969 chr11:928843 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.26 -0.31 2.96e-7 Alzheimer's disease (late onset); CESC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9811920 0.838 rs12488245 chr3:99835254 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.41 5.13 0.3 5.53e-7 Axial length; CESC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg04944784 chr2:26401820 FAM59B -0.67 -7.66 -0.43 3.48e-13 Gut microbiome composition (summer); CESC cis rs67460515 0.892 rs11929238 chr3:161045937 A/T cg03342759 chr3:160939853 NMD3 -0.54 -7.73 -0.43 2.27e-13 Parkinson's disease; CESC cis rs9486719 1.000 rs2472882 chr6:96863474 C/T cg18709589 chr6:96969512 KIAA0776 0.52 5.67 0.33 3.8e-8 Migraine;Coronary artery disease; CESC trans rs208520 0.661 rs207079 chr6:66770462 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.55 -0.61 1.11e-28 Exhaled nitric oxide output; CESC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg25072359 chr17:41440525 NA 0.49 6.51 0.37 3.85e-10 Menopause (age at onset); CESC cis rs17431357 1.000 rs73225245 chr12:120970633 C/T cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC trans rs4942242 0.663 rs7319346 chr13:44218201 T/C cg19169023 chr15:41853346 TYRO3 -0.61 -7.66 -0.43 3.59e-13 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg02187348 chr16:89574699 SPG7 -0.51 -6.86 -0.39 4.81e-11 Multiple myeloma (IgH translocation); CESC cis rs9309473 0.950 rs10198549 chr2:73794404 A/G cg20560298 chr2:73613845 ALMS1 -0.54 -7.08 -0.4 1.31e-11 Metabolite levels; CESC cis rs2980439 0.525 rs2945238 chr8:8170136 A/C cg15556689 chr8:8085844 FLJ10661 0.46 5.53 0.32 7.68e-8 Neuroticism; CESC cis rs963731 0.649 rs297151 chr2:39326511 A/C cg04010122 chr2:39346883 SOS1 -0.67 -5.42 -0.32 1.33e-7 Corticobasal degeneration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22461615 chr4:83821917 THAP9 -0.4 -6.36 -0.36 8.84e-10 Gambling; CESC cis rs6815814 0.950 rs56289835 chr4:38811845 G/C cg02016764 chr4:38805732 TLR1 -0.62 -7.43 -0.42 1.5e-12 Breast cancer; CESC cis rs2979489 0.891 rs7822839 chr8:30354453 A/G cg26383811 chr8:30366931 RBPMS 0.77 9.85 0.52 1.02e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs9479482 1.000 rs11155697 chr6:150357423 C/T cg03788504 chr6:150331562 NA -0.38 -7.2 -0.4 6.04e-12 Alopecia areata; CESC cis rs79349575 0.783 rs4794003 chr17:47029904 C/T cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs2070488 0.804 rs7646429 chr3:38467713 A/G cg24069376 chr3:38537580 EXOG 0.35 5.92 0.34 9.72e-9 Electrocardiographic conduction measures; CESC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs113835537 0.529 rs75685325 chr11:66235242 A/G cg24851651 chr11:66362959 CCS 0.54 6.39 0.37 7.56e-10 Airway imaging phenotypes; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg13696300 chr17:18162128 FLII 0.51 6.78 0.38 7.83e-11 Thyroid stimulating hormone; CESC cis rs2290405 0.527 rs4690332 chr4:910520 C/T cg04824913 chr4:887549 GAK -0.71 -10.42 -0.54 1.6e-21 Systemic sclerosis; CESC cis rs1003719 0.762 rs1015551 chr21:38449510 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.64 0.47 5.56e-16 Eye color traits; CESC cis rs7659604 0.521 rs4833773 chr4:122689245 C/T cg19748678 chr4:122722346 EXOSC9 -0.48 -6.14 -0.35 2.95e-9 Type 2 diabetes; CESC cis rs992157 0.735 rs13393821 chr2:219076742 C/G cg00012203 chr2:219082015 ARPC2 0.86 12.41 0.61 3.57e-28 Colorectal cancer; CESC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg07648498 chr16:89883185 FANCA 0.45 5.56 0.32 6.55e-8 Vitiligo; CESC cis rs62481355 1.000 rs62481355 chr7:127201664 C/T cg25922125 chr7:127225783 GCC1 -0.47 -6.14 -0.35 3.03e-9 Type 2 diabetes; CESC cis rs933688 0.509 rs2941895 chr5:90520510 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.41 -5.16 -0.3 4.85e-7 Smoking behavior; CESC cis rs6088590 0.561 rs6059918 chr20:33150503 C/T cg24642439 chr20:33292090 TP53INP2 0.62 8.24 0.45 8.14e-15 Coronary artery disease; CESC cis rs17023223 0.537 rs55836852 chr1:119725401 G/A cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs7395581 0.918 rs1055510 chr11:47292237 A/G cg25783544 chr11:47291846 MADD 0.62 8.26 0.45 6.99e-15 HDL cholesterol; CESC cis rs8018808 0.905 rs4903586 chr14:77938633 C/G cg20045696 chr14:77926864 AHSA1 -0.47 -6.54 -0.37 3.13e-10 Myeloid white cell count; CESC cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.21 0.31 3.72e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72945132 0.825 rs947811 chr11:70209142 A/T cg14191688 chr11:70257035 CTTN 0.41 5.12 0.3 6.02e-7 Coronary artery disease; CESC cis rs1355223 0.902 rs7102625 chr11:34739717 A/C cg11058730 chr11:34937778 PDHX;APIP 0.47 6.32 0.36 1.09e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg08847533 chr14:75593920 NEK9 -0.94 -16.63 -0.71 5.2e-43 Height; CESC cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7829975 0.688 rs7827182 chr8:8380471 C/G cg06636001 chr8:8085503 FLJ10661 0.51 6.4 0.37 7.17e-10 Mood instability; CESC cis rs868036 0.609 rs2127163 chr15:68090842 C/T cg08079166 chr15:68083412 MAP2K5 0.42 5.77 0.33 2.23e-8 Restless legs syndrome; CESC cis rs9443645 0.901 rs6912683 chr6:79543492 C/A cg05283184 chr6:79620031 NA -0.45 -6.98 -0.39 2.36e-11 Intelligence (multi-trait analysis); CESC cis rs11203032 1.000 rs11203033 chr10:90964731 C/G cg16672925 chr10:90967113 CH25H -0.57 -5.75 -0.33 2.5e-8 Heart failure; CESC trans rs4929949 0.607 rs10840038 chr11:8440949 T/C cg10624583 chr12:53440492 TENC1 -0.45 -6.22 -0.36 1.95e-9 Body mass index; CESC cis rs3106136 0.967 rs61004493 chr4:95163317 T/C cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.8 -0.39 6.92e-11 Capecitabine sensitivity; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08328324 chr8:33370759 C8orf41 -0.46 -6.17 -0.35 2.57e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2933343 1.000 rs876756 chr3:128627623 G/A cg25356066 chr3:128598488 ACAD9 0.61 7.44 0.42 1.42e-12 IgG glycosylation; CESC cis rs965469 0.947 rs56689368 chr20:3332921 G/A cg25506879 chr20:3388711 C20orf194 -0.54 -5.78 -0.33 2.14e-8 IFN-related cytopenia; CESC cis rs60154123 0.730 rs583148 chr1:210463553 A/C cg22029157 chr1:209979665 IRF6 0.49 5.99 0.35 6.7e-9 Coronary artery disease; CESC cis rs1395 0.778 rs2078616 chr2:27441904 A/G cg22903471 chr2:27725779 GCKR -0.42 -5.17 -0.3 4.56e-7 Blood metabolite levels; CESC cis rs7202877 0.656 rs4887812 chr16:75310052 G/A cg04384234 chr16:75411784 CFDP1 -0.46 -5.22 -0.31 3.57e-7 Type 2 diabetes;Type 1 diabetes; CESC cis rs6121246 0.559 rs6121038 chr20:30254773 T/G cg13852791 chr20:30311386 BCL2L1 0.79 10.13 0.53 1.34e-20 Mean corpuscular hemoglobin; CESC cis rs3768617 0.510 rs3768629 chr1:183074582 T/C ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.09e-34 Fuchs's corneal dystrophy; CESC cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg12386194 chr3:101231763 SENP7 0.44 5.38 0.31 1.64e-7 Colorectal cancer; CESC cis rs6546537 0.955 rs2312215 chr2:69839825 T/A cg10773587 chr2:69614142 GFPT1 -0.53 -6.49 -0.37 4.2e-10 Serum thyroid-stimulating hormone levels; CESC cis rs6754311 0.773 rs309176 chr2:136622216 T/C cg07169764 chr2:136633963 MCM6 -0.69 -8.56 -0.47 9.42e-16 Mosquito bite size; CESC cis rs2629540 0.855 rs12776722 chr10:126469833 G/A cg08799069 chr10:126477246 METTL10 0.67 8.46 0.46 1.85e-15 Cocaine dependence; CESC cis rs2760061 0.626 rs2796057 chr1:228124414 G/C cg02753203 chr1:228287806 NA -0.5 -7.22 -0.41 5.36e-12 Diastolic blood pressure; CESC cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg00745463 chr17:30367425 LRRC37B -0.85 -7.72 -0.43 2.36e-13 Hip circumference adjusted for BMI; CESC cis rs9660992 0.710 rs1180721 chr1:205232696 T/C cg00857998 chr1:205179979 DSTYK 0.45 5.22 0.31 3.7e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs2180341 0.814 rs6940933 chr6:127732740 C/G cg24812749 chr6:127587940 RNF146 0.84 11.84 0.59 3.11e-26 Breast cancer; CESC cis rs4319547 0.695 rs11057797 chr12:122860732 G/A cg05707623 chr12:122985044 ZCCHC8 0.56 6.28 0.36 1.35e-9 Body mass index; CESC cis rs6752107 0.967 rs55835501 chr2:234157733 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.45 6.29 0.36 1.29e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs258892 0.895 rs9293443 chr5:72055622 T/C cg21869765 chr5:72125136 TNPO1 -0.42 -5.32 -0.31 2.2e-7 Small cell lung carcinoma; CESC cis rs7560272 0.501 rs2421674 chr2:73955432 G/A cg20560298 chr2:73613845 ALMS1 0.43 5.89 0.34 1.14e-8 Schizophrenia; CESC cis rs7089973 0.604 rs11196942 chr10:116596872 G/A cg25233709 chr10:116636983 FAM160B1 0.38 6.02 0.35 5.7e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6665290 0.836 rs12593 chr1:227172290 A/G cg10327440 chr1:227177885 CDC42BPA 1.18 27.58 0.86 7.27e-80 Myeloid white cell count; CESC cis rs2439831 0.867 rs2264876 chr15:43757419 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.14 0.6 2.88e-27 Lung cancer in ever smokers; CESC cis rs34779708 0.733 rs59287215 chr10:35543994 C/T cg04310649 chr10:35416472 CREM -0.47 -5.38 -0.31 1.67e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs2073300 0.609 rs34648279 chr20:23402935 T/G cg12062639 chr20:23401060 NAPB 1.06 8.23 0.45 8.54e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2066819 0.901 rs773665 chr12:56717466 C/T cg26714650 chr12:56694279 CS 1.28 15.86 0.7 2.7e-40 Psoriasis vulgaris; CESC cis rs72634258 0.572 rs66692705 chr1:7938565 T/C cg00042356 chr1:8021962 PARK7 0.58 5.63 0.33 4.56e-8 Inflammatory bowel disease; CESC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg27535305 chr1:53392650 SCP2 -0.31 -5.07 -0.3 7.6e-7 Monocyte count; CESC cis rs12142240 0.698 rs77185326 chr1:46818417 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC trans rs61931739 0.500 rs7306334 chr12:34482900 A/G cg13010199 chr12:38710504 ALG10B -0.51 -6.68 -0.38 1.39e-10 Morning vs. evening chronotype; CESC cis rs9916302 0.784 rs4795382 chr17:37700860 A/G cg00129232 chr17:37814104 STARD3 -0.57 -7.44 -0.42 1.39e-12 Glomerular filtration rate (creatinine); CESC cis rs2243480 1.000 rs186378 chr7:65582058 A/C cg18252515 chr7:66147081 NA -1.39 -13.92 -0.65 1.93e-33 Diabetic kidney disease; CESC cis rs12701220 0.817 rs7798459 chr7:1087965 C/T cg26769984 chr7:1090371 C7orf50 0.55 6.84 0.39 5.59e-11 Bronchopulmonary dysplasia; CESC cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg05347473 chr6:146136440 FBXO30 -0.54 -7.0 -0.4 2.06e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.15 0.3 5.17e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28647808 0.881 rs7040821 chr9:136263584 C/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg07507251 chr3:52567010 NT5DC2 0.47 8.71 0.47 3.29e-16 Electroencephalogram traits; CESC trans rs2727020 0.729 rs10839283 chr11:49490943 T/C cg03929089 chr4:120376271 NA 0.74 9.57 0.51 7.96e-19 Coronary artery disease; CESC cis rs7927592 0.913 rs12294029 chr11:68257059 A/C cg16797656 chr11:68205561 LRP5 0.41 5.75 0.33 2.51e-8 Total body bone mineral density; CESC cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg05340658 chr4:99064831 C4orf37 0.76 11.13 0.56 7.59e-24 Colonoscopy-negative controls vs population controls; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg05964000 chr1:55564130 USP24 0.4 6.36 0.36 8.69e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9287719 0.967 rs2010080 chr2:10736552 A/T cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.64 7.76 0.43 1.91e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg08704250 chr15:31115839 NA -0.63 -8.9 -0.48 9.14e-17 Huntington's disease progression; CESC cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.64 5.98 0.34 7.35e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2295499 0.700 rs12503424 chr4:2702807 A/G cg08330972 chr4:2403930 ZFYVE28 -0.33 -5.31 -0.31 2.29e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs476633 0.691 rs28735224 chr15:41537539 C/T cg20272979 chr15:41787780 ITPKA 0.38 5.69 0.33 3.3e-8 Glomerular filtration rate (creatinine); CESC cis rs10789491 1.000 rs1890473 chr1:47149794 C/T cg15501359 chr1:47185051 KIAA0494 0.73 8.12 0.45 1.79e-14 Response to hepatitis C treatment; CESC trans rs8073060 0.586 rs2011897 chr17:34054408 A/T cg19694781 chr19:47549865 TMEM160 0.74 6.8 0.39 6.82e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg11764359 chr7:65958608 NA 0.79 11.28 0.57 2.34e-24 Aortic root size; CESC cis rs12464559 0.649 rs6708645 chr2:152620387 A/T cg01189475 chr2:152685088 ARL5A 0.65 5.72 0.33 2.94e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs3126085 0.935 rs1466757 chr1:152212469 G/A cg03465714 chr1:152285911 FLG -0.44 -5.37 -0.31 1.73e-7 Atopic dermatitis; CESC cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 5.92e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4253772 0.530 rs6008662 chr22:46713917 G/A cg00784671 chr22:46762841 CELSR1 -0.39 -5.15 -0.3 5.07e-7 LDL cholesterol;Cholesterol, total; CESC cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg24768116 chr2:27665128 KRTCAP3 -0.33 -5.84 -0.34 1.54e-8 Total body bone mineral density; CESC cis rs3126085 1.000 rs3126098 chr1:152311923 T/C cg03465714 chr1:152285911 FLG 0.44 5.29 0.31 2.61e-7 Atopic dermatitis; CESC cis rs9611565 0.592 rs5758406 chr22:42076641 A/G cg17376030 chr22:41985996 PMM1 -0.67 -7.42 -0.41 1.63e-12 Vitiligo; CESC trans rs1945213 0.694 rs11227113 chr11:55828024 C/T cg15704280 chr7:45808275 SEPT13 0.76 7.31 0.41 3.2e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg06627628 chr2:24431161 ITSN2 -0.63 -5.96 -0.34 8.13e-9 Lymphocyte counts; CESC cis rs7246657 0.943 rs13343471 chr19:37932130 A/G cg23950597 chr19:37808831 NA -0.6 -5.81 -0.34 1.8e-8 Coronary artery calcification; CESC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg04369109 chr6:150039330 LATS1 -0.46 -6.31 -0.36 1.16e-9 Lung cancer; CESC cis rs6546550 0.935 rs1531025 chr2:70055505 G/T cg02498382 chr2:70120550 SNRNP27 -0.39 -6.78 -0.38 7.57e-11 Prevalent atrial fibrillation; CESC cis rs11690935 0.632 rs17581284 chr2:172659376 C/T cg13550731 chr2:172543902 DYNC1I2 0.54 7.63 0.42 4.37e-13 Schizophrenia; CESC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg17221315 chr6:27791827 HIST1H4J 0.63 5.19 0.3 4.29e-7 Depression; CESC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs763121 1.000 rs138464 chr22:38906432 C/T cg06022373 chr22:39101656 GTPBP1 -0.71 -11.0 -0.56 1.95e-23 Menopause (age at onset); CESC trans rs10174398 0.668 rs10205578 chr2:51185310 A/C cg04766043 chr13:114770710 RASA3 0.45 6.01 0.35 6.1e-9 Body mass index; CESC cis rs7607369 0.536 rs6436092 chr2:219669148 T/A cg02176678 chr2:219576539 TTLL4 -0.36 -6.16 -0.35 2.75e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs7223966 1.000 rs78172786 chr17:61847114 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.24 0.36 1.74e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg23048001 chr7:2026167 MAD1L1 -0.47 -6.25 -0.36 1.59e-9 Bipolar disorder and schizophrenia; CESC trans rs7319075 0.657 rs9533543 chr13:44173400 A/G cg01999652 chr6:28220110 ZKSCAN4 0.5 6.19 0.36 2.3e-9 Photic sneeze reflex; CESC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg13393036 chr8:95962371 TP53INP1 -0.49 -9.7 -0.51 3.16e-19 Type 2 diabetes; CESC cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.33 -0.31 2.12e-7 Total body bone mineral density; CESC cis rs2637266 1.000 rs7073355 chr10:78354419 G/A cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs7680126 0.596 rs917826 chr4:10295595 C/G cg11266682 chr4:10021025 SLC2A9 -0.43 -5.66 -0.33 4.02e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs7647973 0.626 rs9830730 chr3:49675875 G/C cg03060546 chr3:49711283 APEH 0.69 8.34 0.46 4.18e-15 Menarche (age at onset); CESC cis rs9902453 0.868 rs12944395 chr17:28323499 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.49 -0.46 1.52e-15 Coffee consumption (cups per day); CESC cis rs238295 0.766 rs6139762 chr20:5546694 C/T cg24001556 chr20:5591874 RP5-1022P6.2 0.45 5.04 0.3 8.51e-7 Occipital cortical area (total cortical area interaction); CESC cis rs3824867 0.804 rs12419342 chr11:47468545 C/T cg20307385 chr11:47447363 PSMC3 0.53 6.42 0.37 6.37e-10 Mean corpuscular hemoglobin; CESC trans rs6089829 0.962 rs6122352 chr20:61668284 T/C cg23505145 chr19:12996616 KLF1 0.51 6.68 0.38 1.37e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg00149659 chr3:10157352 C3orf10 0.76 9.51 0.5 1.26e-18 Alzheimer's disease; CESC cis rs7107174 0.786 rs4945269 chr11:78047077 A/G cg02023728 chr11:77925099 USP35 0.39 5.51 0.32 8.54e-8 Testicular germ cell tumor; CESC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.83 11.61 0.58 1.77e-25 Age-related macular degeneration (geographic atrophy); CESC cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 6.1e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs9283706 0.594 rs10515036 chr5:66343787 A/G cg11590213 chr5:66331682 MAST4 -0.39 -5.4 -0.31 1.5e-7 Coronary artery disease; CESC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.31e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg23283495 chr1:209979779 IRF6 0.47 6.26 0.36 1.54e-9 Cleft lip with or without cleft palate; CESC cis rs6540556 0.859 rs1007693 chr1:209931799 C/T cg23920097 chr1:209922102 NA -0.36 -5.28 -0.31 2.75e-7 Red blood cell count; CESC cis rs9300255 0.664 rs12316131 chr12:123817796 T/C cg00376283 chr12:123451042 ABCB9 -0.59 -6.96 -0.39 2.67e-11 Neutrophil percentage of white cells; CESC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg03351412 chr1:154909251 PMVK 0.59 7.6 0.42 5.09e-13 Prostate cancer; CESC cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.38 0.31 1.66e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.591 rs4721080 chr7:12337785 T/C cg06484146 chr7:12443880 VWDE -0.63 -7.02 -0.4 1.91e-11 Coronary artery disease; CESC trans rs2099077 0.737 rs972797 chr5:102813577 C/A cg07434438 chr16:72961899 ZFHX3 0.47 6.21 0.36 2.03e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg13206674 chr6:150067644 NUP43 0.43 6.03 0.35 5.54e-9 Lung cancer; CESC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg20295408 chr7:1910781 MAD1L1 -0.4 -5.22 -0.31 3.55e-7 Bipolar disorder and schizophrenia; CESC cis rs9291683 0.566 rs13122689 chr4:10044648 A/G cg02734326 chr4:10020555 SLC2A9 0.45 6.19 0.36 2.29e-9 Bone mineral density; CESC cis rs4919044 0.545 rs9420603 chr10:94777490 T/C cg26979504 chr10:94451518 HHEX -0.47 -5.15 -0.3 5.16e-7 Coronary artery disease; CESC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg18904891 chr8:8559673 CLDN23 0.72 8.32 0.46 4.58e-15 Obesity-related traits; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg22328890 chr16:68298258 SLC7A6 -0.53 -6.13 -0.35 3.23e-9 Subjective well-being; CESC cis rs1348850 0.874 rs6742951 chr2:178340766 G/C cg23306229 chr2:178417860 TTC30B 0.65 7.93 0.44 6.03e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11792861 0.816 rs744980 chr9:111690388 C/T cg05043794 chr9:111880884 C9orf5 -0.37 -6.07 -0.35 4.34e-9 Menarche (age at onset); CESC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg07701084 chr6:150067640 NUP43 0.4 5.38 0.31 1.61e-7 Lung cancer; CESC cis rs11112613 0.713 rs58066965 chr12:105952505 C/G cg03607813 chr12:105948248 NA 0.59 7.41 0.41 1.75e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs10752881 0.839 rs2093983 chr1:183094210 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Colorectal cancer; CESC cis rs2832191 1.000 rs2832189 chr21:30487414 C/T cg24692254 chr21:30365293 RNF160 -0.73 -10.98 -0.56 2.27e-23 Dental caries; CESC cis rs6076065 1.000 rs2424538 chr20:23382076 A/G cg12062639 chr20:23401060 NAPB 0.41 5.16 0.3 4.95e-7 Facial morphology (factor 15, philtrum width); CESC cis rs28374715 0.681 rs59000092 chr15:41626148 A/G cg20272979 chr15:41787780 ITPKA 0.39 5.21 0.3 3.76e-7 Ulcerative colitis; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg03404566 chr17:6899310 ALOX12 0.39 6.66 0.38 1.6e-10 Tonsillectomy; CESC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2439831 0.867 rs2255051 chr15:43846161 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.69 8.9 0.48 8.94e-17 Lung cancer in ever smokers; CESC cis rs34779708 0.931 rs12767414 chr10:35390193 C/T cg04310649 chr10:35416472 CREM -0.53 -6.34 -0.36 1.01e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs853679 0.546 rs17695758 chr6:27837183 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.93 6.78 0.38 7.9e-11 Depression; CESC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.44 0.46 2.08e-15 Total body bone mineral density; CESC cis rs12586317 0.547 rs4982236 chr14:35468046 C/G cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC cis rs561341 1.000 rs530715 chr17:30320544 T/G cg19193384 chr17:30244184 NA -0.61 -6.51 -0.37 3.85e-10 Hip circumference adjusted for BMI; CESC cis rs798766 1.000 rs798762 chr4:1731150 T/C cg10756475 chr4:1757242 NA 0.46 6.14 0.35 3.07e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg02297831 chr4:17616191 MED28 0.55 6.81 0.39 6.7e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6060717 0.536 rs11697851 chr20:34524494 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.78 -6.98 -0.39 2.32e-11 Hip circumference adjusted for BMI; CESC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg19193384 chr17:30244184 NA 0.5 5.15 0.3 5.17e-7 Hip circumference adjusted for BMI; CESC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg11764359 chr7:65958608 NA -0.93 -14.86 -0.67 9.49e-37 Aortic root size; CESC cis rs11864453 0.826 rs2072142 chr16:72132713 C/T cg16558253 chr16:72132732 DHX38 -0.61 -9.68 -0.51 3.5e-19 Fibrinogen levels; CESC cis rs920590 0.510 rs4922101 chr8:19648895 A/G cg03894339 chr8:19674705 INTS10 0.74 7.74 0.43 2.11e-13 Acute lymphoblastic leukemia (childhood); CESC trans rs7246657 0.943 rs6508733 chr19:38000548 A/T cg24637308 chr11:6592297 DNHD1 0.51 6.15 0.35 2.89e-9 Coronary artery calcification; CESC cis rs2120019 1.000 rs8036197 chr15:75370232 T/C cg09165964 chr15:75287851 SCAMP5 -0.67 -8.12 -0.45 1.76e-14 Blood trace element (Zn levels); CESC cis rs17401966 0.838 rs8019 chr1:10366487 T/G cg15208524 chr1:10270712 KIF1B 0.42 5.42 0.32 1.32e-7 Hepatocellular carcinoma; CESC cis rs2963155 0.518 rs10515522 chr5:142758394 A/G cg17617527 chr5:142782415 NR3C1 0.74 6.55 0.37 3e-10 Breast cancer; CESC cis rs3125734 0.633 rs6479792 chr10:63983264 T/G cg09941381 chr10:64027924 RTKN2 -0.31 -5.13 -0.3 5.5e-7 Rheumatoid arthritis; CESC trans rs11098499 0.754 rs4443261 chr4:120249301 T/C cg25214090 chr10:38739885 LOC399744 0.62 8.64 0.47 5.24e-16 Corneal astigmatism; CESC cis rs4481887 0.962 rs10788769 chr1:248457426 C/T cg00666640 chr1:248458726 OR2T12 0.4 6.62 0.38 1.97e-10 Common traits (Other); CESC cis rs7917772 0.503 rs7914389 chr10:104295402 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.41 0.41 1.67e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs10911232 0.507 rs2151669 chr1:183055398 T/G ch.1.3577855R chr1:183094577 LAMC1 0.85 13.7 0.64 1.21e-32 Hypertriglyceridemia; CESC cis rs4589502 1.000 rs8023363 chr15:67154654 G/A cg12317470 chr15:67143691 NA 0.66 6.42 0.37 6.24e-10 Lung cancer (smoking interaction); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26080111 chr7:559651 PDGFA -0.51 -6.44 -0.37 5.55e-10 Asthma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07691761 chr5:131892711 RAD50 -0.48 -6.18 -0.35 2.44e-9 Fibrinogen levels; CESC cis rs9486719 1.000 rs9486719 chr6:97060124 G/A cg06623918 chr6:96969491 KIAA0776 -0.82 -9.89 -0.52 7.87e-20 Migraine;Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06662685 chr11:2907073 CDKN1C -0.64 -7.55 -0.42 6.98e-13 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg08888203 chr3:10149979 C3orf24 0.45 5.82 0.34 1.68e-8 Alzheimer's disease; CESC cis rs13082711 0.516 rs1388785 chr3:27371843 T/C cg02860705 chr3:27208620 NA -0.55 -6.94 -0.39 2.99e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg01017244 chr2:74357527 NA 0.8 11.7 0.58 8.91e-26 Gestational age at birth (maternal effect); CESC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg04155289 chr7:94953770 PON1 -0.45 -6.83 -0.39 5.85e-11 Paraoxonase activity; CESC cis rs7818688 1.000 rs7832570 chr8:96023795 A/T cg16049864 chr8:95962084 TP53INP1 0.61 5.77 0.33 2.17e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs12900413 0.645 rs28407340 chr15:90311864 C/T cg24249390 chr15:90295951 MESP1 -0.41 -5.66 -0.33 4.03e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs3105593 1.000 rs28718130 chr15:50909489 G/A cg08437265 chr15:50716283 USP8 0.4 5.13 0.3 5.69e-7 QT interval; CESC cis rs6964587 1.000 rs6952671 chr7:91597934 C/A cg17063962 chr7:91808500 NA 0.57 7.82 0.43 1.22e-13 Breast cancer; CESC cis rs644799 0.930 rs587123 chr11:95560539 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.09 0.49 2.43e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg18252515 chr7:66147081 NA -0.47 -6.42 -0.37 6.18e-10 Aortic root size; CESC cis rs1008375 0.932 rs4698626 chr4:17605821 G/C cg27347728 chr4:17578864 LAP3 0.43 5.29 0.31 2.51e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs798766 1.000 rs798755 chr4:1720824 A/G cg05874882 chr4:1763078 NA -0.6 -8.64 -0.47 5.49e-16 Bladder cancer;Urinary bladder cancer; CESC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.93 0.39 3.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3213545 0.700 rs2260399 chr12:121469653 C/T cg02403541 chr12:121454288 C12orf43 0.68 9.72 0.51 2.62e-19 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs67478160 0.584 rs2295148 chr14:104195610 T/C cg01849466 chr14:104193079 ZFYVE21 -0.59 -8.78 -0.47 2.09e-16 Schizophrenia; CESC cis rs7223966 1.000 rs8067431 chr17:61817048 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.09 -0.3 6.84e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6540559 0.673 rs7525951 chr1:210018306 C/T cg22029157 chr1:209979665 IRF6 -0.66 -7.44 -0.42 1.42e-12 Cleft lip with or without cleft palate; CESC cis rs3091242 0.933 rs35403885 chr1:25784551 G/A cg02931644 chr1:25747376 RHCE -0.39 -6.53 -0.37 3.37e-10 Erythrocyte sedimentation rate; CESC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg11644478 chr21:40555479 PSMG1 -1.01 -15.63 -0.69 1.82e-39 Cognitive function; CESC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg07636037 chr3:49044803 WDR6 0.8 13.31 0.63 2.63e-31 Menarche (age at onset); CESC cis rs9303401 1.000 rs9303401 chr17:56847945 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.74 9.58 0.51 7.58e-19 Cognitive test performance; CESC cis rs7647973 0.593 rs4855885 chr3:49690199 G/A cg06212747 chr3:49208901 KLHDC8B 0.62 7.06 0.4 1.46e-11 Menarche (age at onset); CESC cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7940866 0.903 rs10791109 chr11:130850377 A/C cg12179176 chr11:130786555 SNX19 0.55 7.92 0.44 6.66e-14 Schizophrenia; CESC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.09 -13.46 -0.64 8.09e-32 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.97 0.8 1.29e-61 Prudent dietary pattern; CESC cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg18305652 chr10:134549665 INPP5A 0.51 7.67 0.43 3.3e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs5769765 0.955 rs8139758 chr22:50261123 G/T cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs12900413 0.687 rs28752094 chr15:90311645 G/A cg24249390 chr15:90295951 MESP1 -0.41 -5.63 -0.33 4.51e-8 Coronary artery aneurysm in Kawasaki disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17397401 chr15:75230745 COX5A 0.43 6.01 0.35 5.98e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11650494 0.908 rs11650087 chr17:47362923 T/A cg08112188 chr17:47440006 ZNF652 1.25 8.25 0.45 7.6e-15 Prostate cancer; CESC cis rs727505 0.866 rs66852389 chr7:124724348 T/A cg23710748 chr7:124431027 NA -0.4 -6.52 -0.37 3.56e-10 Lewy body disease; CESC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg13880726 chr7:1868755 MAD1L1 0.5 6.65 0.38 1.65e-10 Bipolar disorder and schizophrenia; CESC cis rs9902453 0.817 rs880749 chr17:28059970 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -8.41 -0.46 2.55e-15 Coffee consumption (cups per day); CESC cis rs9399135 0.967 rs9389251 chr6:135325717 A/G cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg18402987 chr7:1209562 NA 0.57 6.64 0.38 1.72e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg22105103 chr4:187893119 NA 0.51 7.69 0.43 2.88e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg06713675 chr4:122721982 EXOSC9 -0.51 -7.02 -0.4 1.9e-11 Type 2 diabetes; CESC cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.15e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1950626 0.787 rs34857222 chr14:101391354 G/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.8 10.8 0.55 9.22e-23 Pelvic organ prolapse (moderate/severe); CESC cis rs10465746 0.846 rs12146038 chr1:84405065 A/T cg10977910 chr1:84465055 TTLL7 0.46 6.25 0.36 1.67e-9 Obesity-related traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13353311 chr5:59996240 DEPDC1B -0.45 -6.32 -0.36 1.09e-9 Gut microbiota (bacterial taxa); CESC cis rs59918340 0.523 rs4961255 chr8:142208248 T/C cg18755752 chr8:142205143 DENND3 -0.44 -5.6 -0.33 5.28e-8 Immature fraction of reticulocytes; CESC cis rs72945132 0.619 rs61887436 chr11:70243337 C/T cg00319359 chr11:70116639 PPFIA1 0.65 5.51 0.32 8.7e-8 Coronary artery disease; CESC cis rs12725198 0.507 rs41393951 chr1:16053493 C/T cg18133145 chr1:16060689 PLEKHM2 -0.53 -6.33 -0.36 1.05e-9 Cardiac Troponin-T levels; CESC cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 10.02 0.52 2.95e-20 Platelet count; CESC cis rs568617 0.953 rs658938 chr11:65651830 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.69 -7.4 -0.41 1.81e-12 Crohn's disease; CESC cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg22496339 chr2:162101262 NA 0.5 6.62 0.38 1.94e-10 Intelligence (multi-trait analysis); CESC trans rs9329221 0.683 rs3105738 chr8:9889914 A/T cg06636001 chr8:8085503 FLJ10661 -0.55 -7.56 -0.42 6.49e-13 Neuroticism; CESC cis rs9309473 0.950 rs1918863 chr2:73644481 A/G cg20560298 chr2:73613845 ALMS1 -0.49 -6.75 -0.38 9.2e-11 Metabolite levels; CESC cis rs6500395 1.000 rs1386040 chr16:48631207 A/G cg04672837 chr16:48644449 N4BP1 0.52 6.65 0.38 1.7e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs826838 1.000 rs11168676 chr12:38977304 A/G cg13010199 chr12:38710504 ALG10B 0.58 8.14 0.45 1.59e-14 Heart rate; CESC cis rs7666738 0.546 rs2098935 chr4:98914376 A/G cg17366294 chr4:99064904 C4orf37 0.52 6.57 0.37 2.65e-10 Colonoscopy-negative controls vs population controls; CESC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg07167872 chr1:205819463 PM20D1 0.77 12.69 0.61 3.68e-29 Menarche (age at onset); CESC cis rs12188164 0.543 rs2672757 chr5:454732 A/G cg16584290 chr5:462447 EXOC3 0.48 7.35 0.41 2.48e-12 Cystic fibrosis severity; CESC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.69 0.33 3.3e-8 Personality dimensions; CESC cis rs763121 0.853 rs9610986 chr22:39025277 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.77e-16 Menopause (age at onset); CESC cis rs1348850 0.914 rs12612857 chr2:178467144 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.66 8.68 0.47 4.07e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7267979 1.000 rs761025 chr20:25426968 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.83 16.43 0.71 2.68e-42 Liver enzyme levels (alkaline phosphatase); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07454192 chr8:74888262 TMEM70 0.46 6.44 0.37 5.6e-10 Systemic lupus erythematosus; CESC cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg08847533 chr14:75593920 NEK9 -1.03 -20.52 -0.78 1.11e-56 Height; CESC cis rs6736093 0.966 rs35189728 chr2:112720228 C/G cg12686935 chr2:112915763 FBLN7 -0.43 -5.56 -0.32 6.75e-8 Coronary artery disease; CESC cis rs8060686 0.545 rs9922165 chr16:68181177 C/A cg26727032 chr16:67993705 SLC12A4 -0.5 -6.15 -0.35 2.84e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg10691866 chr7:65817282 TPST1 0.32 5.3 0.31 2.49e-7 Aortic root size; CESC cis rs11997175 0.583 rs34540455 chr8:33799300 C/T ch.8.33884649F chr8:33765107 NA 0.47 5.96 0.34 8.11e-9 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17185401 chr1:110052093 AMIGO1 0.59 7.0 0.4 2.05e-11 Gut microbiome composition (summer); CESC cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg00745463 chr17:30367425 LRRC37B -0.88 -7.7 -0.43 2.74e-13 Hip circumference adjusted for BMI; CESC cis rs17376456 0.877 rs13185660 chr5:93336500 G/A cg25358565 chr5:93447407 FAM172A 1.09 10.4 0.54 1.88e-21 Diabetic retinopathy; CESC cis rs9291683 0.566 rs13144709 chr4:10044182 C/T cg11266682 chr4:10021025 SLC2A9 0.65 12.28 0.6 9.55e-28 Bone mineral density; CESC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg12310025 chr6:25882481 NA 0.45 6.51 0.37 3.85e-10 Intelligence (multi-trait analysis); CESC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg03709012 chr19:19516395 GATAD2A 1.01 15.11 0.68 1.22e-37 Tonsillectomy; CESC cis rs2637266 1.000 rs1907314 chr10:78337948 G/A cg18941641 chr10:78392320 NA 0.42 7.59 0.42 5.44e-13 Pulmonary function; CESC cis rs6496667 0.557 rs2526002 chr15:90965655 C/T cg22089800 chr15:90895588 ZNF774 0.43 5.53 0.32 7.57e-8 Rheumatoid arthritis; CESC cis rs9788682 1.000 rs7164594 chr15:78803057 C/T cg24631222 chr15:78858424 CHRNA5 0.71 8.67 0.47 4.33e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs4853012 0.887 rs6737314 chr2:74339586 A/G cg05776053 chr2:74358815 NA 0.46 5.72 0.33 2.84e-8 Gestational age at birth (maternal effect); CESC cis rs7605827 0.930 rs11675921 chr2:15569376 C/T cg19274914 chr2:15703543 NA -0.32 -5.48 -0.32 9.98e-8 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26871885 chr11:207525 RIC8A;BET1L 0.67 7.88 0.44 8.52e-14 Gut microbiome composition (summer); CESC cis rs9611519 0.580 rs7286603 chr22:41440061 T/C cg03806693 chr22:41940476 POLR3H -0.51 -6.04 -0.35 5.14e-9 Neuroticism; CESC cis rs6088580 0.634 rs6088502 chr20:33037644 A/T cg06115741 chr20:33292138 TP53INP2 0.47 6.04 0.35 5.1e-9 Glomerular filtration rate (creatinine); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18727501 chr4:89513542 HERC3 -0.37 -6.02 -0.35 5.93e-9 Gambling; CESC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg27541892 chr1:1571801 CDK11B -0.59 -7.94 -0.44 5.84e-14 Body mass index; CESC cis rs2404602 0.684 rs157759 chr15:76846990 T/A cg23625390 chr15:77176239 SCAPER 0.41 5.69 0.33 3.37e-8 Blood metabolite levels; CESC cis rs4566357 0.615 rs12474622 chr2:227912793 A/G cg11843606 chr2:227700838 RHBDD1 -0.5 -6.83 -0.39 5.8e-11 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19606096 chr12:93861141 MRPL42 0.52 7.2 0.4 6.21e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16739247 chr1:76252438 SNORD45C;SNORD45A;RABGGTB -0.43 -6.16 -0.35 2.65e-9 Gambling; CESC cis rs4253772 0.591 rs6007795 chr22:46686792 C/G cg18190219 chr22:46762943 CELSR1 -0.43 -5.4 -0.31 1.46e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9902453 0.967 rs17825877 chr17:28515188 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.84 0.43 1.07e-13 Coffee consumption (cups per day); CESC cis rs3782089 1.000 rs3782089 chr11:65336819 C/T cg00206168 chr11:65308501 LTBP3 0.91 6.6 0.38 2.2e-10 Height; CESC cis rs35146811 0.807 rs6953441 chr7:99617067 G/A cg13334819 chr7:99746414 C7orf59 -0.45 -5.24 -0.31 3.34e-7 Coronary artery disease; CESC cis rs6088580 0.608 rs8114616 chr20:32969092 G/T cg24642439 chr20:33292090 TP53INP2 -0.5 -6.65 -0.38 1.72e-10 Glomerular filtration rate (creatinine); CESC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg17372223 chr3:52568218 NT5DC2 0.44 6.63 0.38 1.86e-10 Bipolar disorder; CESC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg09177884 chr7:1199841 ZFAND2A -0.54 -6.1 -0.35 3.74e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2228479 0.717 rs11644967 chr16:89806614 T/A cg00800038 chr16:89945340 TCF25 -0.66 -6.35 -0.36 9.43e-10 Skin colour saturation; CESC cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg03806693 chr22:41940476 POLR3H 1.18 14.22 0.66 1.73e-34 Vitiligo; CESC cis rs13392177 0.684 rs6720449 chr2:219080978 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.52 -6.43 -0.37 5.97e-10 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs7520050 0.931 rs6697557 chr1:46307809 G/A cg03146154 chr1:46216737 IPP -0.48 -6.3 -0.36 1.25e-9 Red blood cell count;Reticulocyte count; CESC cis rs11155671 0.530 rs9322228 chr6:150209309 C/G cg09699651 chr6:150184138 LRP11 0.55 7.7 0.43 2.78e-13 Testicular germ cell tumor; CESC cis rs7254114 0.645 rs61045132 chr19:11303068 C/T cg02815516 chr19:11306319 KANK2 -0.37 -5.73 -0.33 2.74e-8 Immature fraction of reticulocytes; CESC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg23978390 chr7:1156363 C7orf50 0.6 8.64 0.47 5.54e-16 Longevity;Endometriosis; CESC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg08632164 chr7:65971372 NA -0.32 -5.17 -0.3 4.72e-7 Aortic root size; CESC cis rs78456975 0.699 rs17091772 chr2:1519679 A/C cg26248373 chr2:1572462 NA -0.5 -5.1 -0.3 6.47e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg25072359 chr17:41440525 NA 0.48 7.1 0.4 1.18e-11 Menopause (age at onset); CESC cis rs7607369 0.580 rs17573731 chr2:219652153 T/C cg02176678 chr2:219576539 TTLL4 -0.48 -8.58 -0.47 8.14e-16 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.75 9.58 0.51 7.43e-19 Height; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23811096 chr1:33502772 AK2 -0.48 -6.37 -0.36 8.52e-10 Asthma; CESC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg20295408 chr7:1910781 MAD1L1 -0.44 -5.8 -0.34 1.91e-8 Bipolar disorder and schizophrenia; CESC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Tonsillectomy; CESC cis rs7223966 1.000 rs6504171 chr17:61710010 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.44 0.42 1.37e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -8.98 -0.48 5.05e-17 Developmental language disorder (linguistic errors); CESC cis rs6089584 0.924 rs6142906 chr20:60552554 G/C cg13770153 chr20:60521292 NA -0.45 -5.8 -0.34 1.89e-8 Body mass index; CESC cis rs6912958 0.935 rs6454629 chr6:88165515 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.58 -7.97 -0.44 4.72e-14 Monocyte percentage of white cells; CESC cis rs9581857 0.556 rs1885991 chr13:28040470 G/A cg22138327 chr13:27999177 GTF3A 0.64 7.1 0.4 1.16e-11 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg15147215 chr3:52552868 STAB1 -0.39 -7.14 -0.4 8.74e-12 Electroencephalogram traits; CESC cis rs7412746 0.611 rs4970985 chr1:150887442 C/T cg22823121 chr1:150693482 HORMAD1 -0.36 -5.06 -0.3 7.78e-7 Melanoma; CESC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg08736216 chr1:53307985 ZYG11A 0.42 7.11 0.4 1.06e-11 Monocyte count; CESC cis rs1729951 0.546 rs835632 chr3:136676525 A/T cg04103450 chr3:136751342 NA 0.39 5.24 0.31 3.34e-7 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01170069 chr5:32599084 SUB1 -0.54 -6.71 -0.38 1.18e-10 Gut microbiome composition (summer); CESC cis rs2380220 1.000 rs9400318 chr6:95972381 T/A cg15832292 chr6:96025679 MANEA 0.68 6.27 0.36 1.49e-9 Behavioural disinhibition (generation interaction); CESC cis rs2625529 0.730 rs1481861 chr15:72240129 A/G cg16672083 chr15:72433130 SENP8 0.42 6.0 0.35 6.62e-9 Red blood cell count; CESC cis rs4268898 0.608 rs72793980 chr2:24428859 T/C cg20701182 chr2:24300061 SF3B14 0.54 6.13 0.35 3.17e-9 Asthma; CESC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg05872129 chr22:39784769 NA -0.82 -11.28 -0.57 2.39e-24 Intelligence (multi-trait analysis); CESC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg09658497 chr7:2847517 GNA12 -0.43 -6.03 -0.35 5.55e-9 Height; CESC cis rs6570726 0.818 rs437978 chr6:145809134 A/G cg23711669 chr6:146136114 FBXO30 0.88 13.11 0.63 1.36e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg11764359 chr7:65958608 NA 0.7 10.02 0.52 3.02e-20 Aortic root size; CESC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg26314531 chr2:26401878 FAM59B 0.73 7.72 0.43 2.42e-13 Gut microbiome composition (summer); CESC cis rs12765878 1.000 rs11191849 chr10:105650880 T/A cg11005552 chr10:105648138 OBFC1 0.36 5.24 0.31 3.32e-7 Coronary artery disease; CESC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg24101359 chr6:42928495 GNMT 0.68 10.8 0.55 9.07e-23 Alzheimer's disease in APOE e4+ carriers; CESC cis rs593982 0.920 rs1108922 chr11:65423930 C/T cg08755490 chr11:65554678 OVOL1 -1.11 -8.33 -0.46 4.31e-15 Atopic dermatitis; CESC cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg06212747 chr3:49208901 KLHDC8B 0.67 8.99 0.48 4.66e-17 Parkinson's disease; CESC cis rs12928939 0.517 rs12934512 chr16:71965230 C/G cg03805757 chr16:71968109 PKD1L3 -0.59 -6.62 -0.38 2.01e-10 Post bronchodilator FEV1; CESC cis rs2404602 0.598 rs71405204 chr15:76635305 C/G cg00316803 chr15:76480434 C15orf27 0.46 6.13 0.35 3.21e-9 Blood metabolite levels; CESC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.92 -0.34 9.86e-9 Parkinson's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18029778 chr7:104654746 MLL5;LOC100216545 -0.44 -6.05 -0.35 4.84e-9 Fibrinogen levels; CESC cis rs2115630 1.000 rs7183401 chr15:85371944 G/T cg12501888 chr15:85177176 SCAND2 -0.4 -5.23 -0.31 3.48e-7 P wave terminal force; CESC cis rs7512552 0.839 rs17596326 chr1:150433819 A/G cg15654264 chr1:150340011 RPRD2 0.39 5.19 0.3 4.1e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg01579765 chr21:45077557 HSF2BP -0.52 -9.24 -0.49 8.14e-18 Mean corpuscular volume; CESC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg20243544 chr17:37824526 PNMT 0.48 6.01 0.35 5.96e-9 Glomerular filtration rate (creatinine); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25867694 chr22:31503597 SELM -0.5 -6.78 -0.38 7.63e-11 Fibrinogen levels; CESC trans rs7839040 0.698 rs997281 chr8:82923482 A/G cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs7178572 0.568 rs11632941 chr15:77533888 A/G cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg20243544 chr17:37824526 PNMT 0.5 6.35 0.36 9.07e-10 Glomerular filtration rate (creatinine); CESC cis rs290268 0.874 rs290988 chr9:93562955 C/G cg02608019 chr9:93564028 SYK 0.63 9.64 0.51 4.92e-19 Platelet count; CESC cis rs1461503 0.966 rs7110154 chr11:122843300 A/G cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs7772486 0.790 rs6924159 chr6:146267873 A/G cg05347473 chr6:146136440 FBXO30 -0.57 -7.26 -0.41 4.32e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs10751667 0.714 rs7396700 chr11:963863 A/C cg06064525 chr11:970664 AP2A2 -0.47 -9.32 -0.5 4.88e-18 Alzheimer's disease (late onset); CESC cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg23711669 chr6:146136114 FBXO30 0.99 15.04 0.68 2.25e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs7267979 1.000 rs6050542 chr20:25318879 T/C cg08601574 chr20:25228251 PYGB -0.39 -5.61 -0.33 5.02e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs858239 0.539 rs4294098 chr7:23185995 G/A cg23682824 chr7:23144976 KLHL7 0.5 6.56 0.37 2.77e-10 Cerebrospinal fluid biomarker levels; CESC cis rs10979 0.597 rs9496685 chr6:143908690 G/A cg25407410 chr6:143891975 LOC285740 -0.49 -6.57 -0.37 2.58e-10 Hypospadias; CESC cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.03 0.3 9.17e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg08470875 chr2:26401718 FAM59B -0.69 -7.09 -0.4 1.25e-11 Gut microbiome composition (summer); CESC cis rs4720575 0.839 rs10255464 chr7:47097043 A/G cg00036614 chr7:47093842 NA -0.41 -6.46 -0.37 5.1e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs589448 0.902 rs315138 chr12:69764850 A/T cg14784868 chr12:69753453 YEATS4 0.89 14.23 0.66 1.66e-34 Cerebrospinal fluid biomarker levels; CESC cis rs75804782 0.641 rs72987321 chr2:239352765 T/G cg18131467 chr2:239335373 ASB1 -0.67 -5.91 -0.34 1.06e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs365132 0.875 rs4490607 chr5:176349386 T/C cg16309518 chr5:176445507 NA -0.37 -5.38 -0.31 1.6e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs3749237 0.595 rs4855873 chr3:49459114 A/C cg06212747 chr3:49208901 KLHDC8B 0.52 7.08 0.4 1.3e-11 Resting heart rate; CESC cis rs847577 0.609 rs17435590 chr7:97784061 T/C cg21770322 chr7:97807741 LMTK2 0.83 13.85 0.65 3.33e-33 Breast cancer; CESC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg11764359 chr7:65958608 NA 0.97 15.73 0.69 7.9e-40 Aortic root size; CESC cis rs2243480 1.000 rs2707831 chr7:66062511 G/A cg12463550 chr7:65579703 CRCP 0.74 5.83 0.34 1.61e-8 Diabetic kidney disease; CESC cis rs2070677 0.935 rs4351775 chr10:135402200 C/T cg20169779 chr10:135381914 SYCE1 -0.78 -10.55 -0.54 5.78e-22 Gout; CESC trans rs61931739 0.500 rs7979240 chr12:34509026 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.53 0.54 6.75e-22 Morning vs. evening chronotype; CESC cis rs2820292 0.595 rs10800793 chr1:201825750 A/G cg06775570 chr1:201857621 SHISA4 -0.31 -5.06 -0.3 7.68e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs34526934 0.608 rs34720456 chr2:177027292 G/A cg14324370 chr2:177042789 NA -0.5 -6.1 -0.35 3.65e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs7772486 0.875 rs10457794 chr6:146415608 A/G cg05347473 chr6:146136440 FBXO30 0.51 6.68 0.38 1.37e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9611565 0.649 rs202645 chr22:41798520 A/G cg17376030 chr22:41985996 PMM1 -0.7 -7.47 -0.42 1.14e-12 Vitiligo; CESC cis rs644799 0.648 rs1255181 chr11:95472148 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.51 7.05 0.4 1.58e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs227584 0.663 rs2040810 chr17:42243771 C/T cg13607699 chr17:42295918 UBTF -0.42 -5.33 -0.31 2.09e-7 Bone mineral density (hip);Bone mineral density; CESC cis rs6964587 0.904 rs2023785 chr7:91547369 C/A cg01689657 chr7:91764605 CYP51A1 -0.28 -5.06 -0.3 7.76e-7 Breast cancer; CESC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg02187348 chr16:89574699 SPG7 0.63 8.79 0.48 1.97e-16 Multiple myeloma (IgH translocation); CESC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg02099474 chr7:1027990 CYP2W1 -0.34 -5.12 -0.3 6.01e-7 Longevity;Endometriosis; CESC cis rs17253792 0.822 rs75016910 chr14:56050466 C/G cg01858014 chr14:56050164 KTN1 -0.97 -7.16 -0.4 8.08e-12 Putamen volume; CESC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg17724175 chr1:150552817 MCL1 0.41 6.18 0.35 2.39e-9 Tonsillectomy; CESC cis rs2274273 0.805 rs7159808 chr14:55624327 G/T cg04306507 chr14:55594613 LGALS3 0.29 5.82 0.34 1.72e-8 Protein biomarker; CESC cis rs8018808 1.000 rs4903580 chr14:77850978 C/T cg20045696 chr14:77926864 AHSA1 -0.41 -5.68 -0.33 3.54e-8 Myeloid white cell count; CESC cis rs2011503 0.943 rs8102502 chr19:19652746 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.1 0.3 6.63e-7 Bipolar disorder; CESC cis rs9487051 0.676 rs6933326 chr6:109601333 C/T cg12927641 chr6:109611667 NA -0.36 -5.47 -0.32 1.04e-7 Reticulocyte fraction of red cells; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04338281 chr16:54962385 NA -0.47 -6.42 -0.37 6.23e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg26314531 chr2:26401878 FAM59B -0.83 -9.26 -0.49 7.37e-18 Gut microbiome composition (summer); CESC cis rs61776719 0.500 rs11210866 chr1:38449565 T/C cg18451016 chr1:38461880 NA 0.42 6.29 0.36 1.33e-9 Coronary artery disease; CESC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.88e-10 Life satisfaction; CESC cis rs2072732 0.861 rs72629493 chr1:2951347 G/A cg15211996 chr1:2936768 ACTRT2 0.34 5.95 0.34 8.31e-9 Plateletcrit; CESC cis rs116095464 0.558 rs7710005 chr5:233572 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.49 5.1 0.3 6.58e-7 Breast cancer; CESC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs8060686 0.920 rs56845922 chr16:67770828 T/C cg26727032 chr16:67993705 SLC12A4 -0.57 -5.98 -0.34 7.34e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs7917772 0.539 rs12572775 chr10:104285594 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.39 -5.38 -0.31 1.67e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2204008 0.805 rs2874289 chr12:38258420 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.62 0.55 3.58e-22 Bladder cancer; CESC cis rs4728302 0.869 rs13228262 chr7:133598288 A/G cg10665199 chr7:133106180 EXOC4 0.42 5.83 0.34 1.57e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs1609391 0.567 rs835633 chr3:136676496 T/C cg04103450 chr3:136751342 NA 0.4 5.28 0.31 2.7e-7 Neuroticism; CESC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg23281280 chr6:28129359 ZNF389 0.57 7.67 0.43 3.3e-13 Depression; CESC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg11764359 chr7:65958608 NA 0.53 6.98 0.39 2.34e-11 Aortic root size; CESC cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg15506890 chr2:3487001 NA -0.49 -6.23 -0.36 1.83e-9 Neurofibrillary tangles; CESC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg02725872 chr8:58115012 NA -0.42 -5.8 -0.34 1.84e-8 Developmental language disorder (linguistic errors); CESC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg13628971 chr7:2884303 GNA12 0.67 8.72 0.47 3.16e-16 Height; CESC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg06808227 chr14:105710500 BRF1 -0.64 -7.65 -0.43 3.72e-13 Mean platelet volume;Platelet distribution width; CESC trans rs1728785 1.000 rs698717 chr16:68560199 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.64 7.42 0.41 1.61e-12 Ulcerative colitis; CESC cis rs3812831 0.662 rs418027 chr13:114929344 A/C cg08824895 chr13:115047677 UPF3A 0.41 5.34 0.31 1.98e-7 Schizophrenia; CESC cis rs6815814 0.950 rs5743595 chr4:38802644 A/G cg02016764 chr4:38805732 TLR1 -0.63 -7.49 -0.42 1.05e-12 Breast cancer; CESC cis rs9611565 0.840 rs4822025 chr22:41776646 C/G cg17376030 chr22:41985996 PMM1 0.65 7.06 0.4 1.45e-11 Vitiligo; CESC cis rs56235845 0.665 rs4976685 chr5:176766177 C/T cg16006841 chr5:176797999 RGS14 -0.49 -6.44 -0.37 5.56e-10 Hemoglobin concentration;Hematocrit; CESC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg11764359 chr7:65958608 NA -0.8 -8.87 -0.48 1.14e-16 Aortic root size; CESC cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 6.17 0.35 2.48e-9 Colorectal cancer; CESC cis rs7107174 1.000 rs11237456 chr11:78040780 C/G cg02023728 chr11:77925099 USP35 0.4 5.73 0.33 2.69e-8 Testicular germ cell tumor; CESC cis rs9660992 0.539 rs113699533 chr1:205122895 G/A cg00857998 chr1:205179979 DSTYK 0.58 7.45 0.42 1.34e-12 Mean corpuscular volume;Mean platelet volume; CESC cis rs116095464 0.558 rs11959126 chr5:283880 T/G cg22857025 chr5:266934 NA -1.29 -18.38 -0.75 3.21e-49 Breast cancer; CESC cis rs9479482 0.967 rs11752529 chr6:150347971 C/T cg03788504 chr6:150331562 NA -0.37 -7.03 -0.4 1.8e-11 Alopecia areata; CESC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg16325326 chr1:53192061 ZYG11B 0.81 12.77 0.62 2.07e-29 Monocyte count; CESC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -7.03 -0.4 1.8e-11 Extrinsic epigenetic age acceleration; CESC cis rs10751667 1.000 rs11246359 chr11:967943 T/C cg20946044 chr11:1010712 AP2A2 -0.44 -5.91 -0.34 1.06e-8 Alzheimer's disease (late onset); CESC cis rs3733585 0.673 rs4235347 chr4:9951956 C/T cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4253772 0.744 rs9627278 chr22:46643432 C/G cg24881330 chr22:46731750 TRMU 0.64 6.28 0.36 1.41e-9 LDL cholesterol;Cholesterol, total; CESC cis rs6714710 0.603 rs13023980 chr2:98502987 T/C cg26665480 chr2:98280029 ACTR1B 0.57 7.97 0.44 4.74e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs7119 0.717 rs35268067 chr15:77753688 C/G cg17802220 chr15:77601643 NA -0.52 -7.27 -0.41 4.08e-12 Type 2 diabetes; CESC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg18230493 chr5:56204884 C5orf35 -0.73 -8.61 -0.47 6.69e-16 Initial pursuit acceleration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18732869 chr19:6739680 TRIP10 -0.44 -6.12 -0.35 3.4e-9 Fibrinogen levels; CESC trans rs1814175 0.645 rs1721995 chr11:49915488 A/G cg15704280 chr7:45808275 SEPT13 -0.98 -18.48 -0.75 1.48e-49 Height; CESC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -12.1 -0.6 3.91e-27 Alzheimer's disease; CESC trans rs1945213 0.694 rs12422168 chr11:55866840 A/G cg15704280 chr7:45808275 SEPT13 0.69 6.65 0.38 1.66e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs67311347 0.956 rs6771527 chr3:40506548 T/C cg09455208 chr3:40491958 NA -0.48 -8.14 -0.45 1.52e-14 Renal cell carcinoma; CESC cis rs472402 0.580 rs3736316 chr5:6656210 G/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.55 -7.06 -0.4 1.43e-11 Response to amphetamines; CESC cis rs9581857 0.615 rs79793528 chr13:28007823 G/A cg01674679 chr13:27998804 GTF3A -0.71 -5.67 -0.33 3.75e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs9929218 1.000 rs2113199 chr16:68814502 A/G cg02972257 chr16:68554789 NA 0.48 5.71 0.33 2.96e-8 Colorectal cancer; CESC cis rs12701220 0.689 rs12701824 chr7:1102364 G/A cg02733842 chr7:1102375 C7orf50 -0.41 -5.07 -0.3 7.39e-7 Bronchopulmonary dysplasia; CESC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg10351095 chr21:47802916 PCNT 0.48 5.89 0.34 1.15e-8 Testicular germ cell tumor; CESC cis rs6499129 0.764 rs16957291 chr16:67326102 T/A cg26727032 chr16:67993705 SLC12A4 -0.51 -5.59 -0.32 5.61e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.72 -0.58 7.7e-26 Type 2 diabetes; CESC cis rs8058578 0.945 rs34480360 chr16:30798689 G/A cg02466173 chr16:30829666 NA -0.5 -7.57 -0.42 6.04e-13 Multiple myeloma; CESC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg06634786 chr22:41940651 POLR3H -0.7 -7.53 -0.42 8e-13 Vitiligo; CESC cis rs7843479 0.965 rs11775479 chr8:21859991 C/T cg17168535 chr8:21777572 XPO7 0.48 6.58 0.37 2.51e-10 Mean corpuscular volume; CESC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg13647721 chr17:30228624 UTP6 0.7 6.81 0.39 6.38e-11 Hip circumference adjusted for BMI; CESC cis rs873946 0.564 rs12242672 chr10:134555609 A/T cg27297192 chr10:134578999 INPP5A 0.37 5.07 0.3 7.4e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs8099014 0.731 rs4940391 chr18:56105868 A/G cg12827950 chr18:55968429 NEDD4L -0.52 -5.54 -0.32 7.23e-8 Platelet count; CESC trans rs9348721 0.673 rs9358934 chr6:26363755 G/C cg06606381 chr12:133084897 FBRSL1 -0.76 -7.01 -0.4 1.97e-11 Intelligence (multi-trait analysis); CESC cis rs68170813 0.641 rs6979368 chr7:107089009 C/G cg02696742 chr7:106810147 HBP1 -0.56 -5.19 -0.3 4.1e-7 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11074549 chr14:75642944 TMED10 -0.52 -6.48 -0.37 4.46e-10 Ulcerative colitis; CESC cis rs6032067 0.641 rs34313230 chr20:43755858 C/G cg10761708 chr20:43804764 PI3 0.5 5.25 0.31 3.12e-7 Blood protein levels; CESC cis rs12477438 0.501 rs12613624 chr2:99732741 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.78 -12.89 -0.62 7.58e-30 Chronic sinus infection; CESC cis rs9308433 0.529 rs4655332 chr1:214490756 G/A cg06198575 chr1:214491504 SMYD2 0.49 5.8 0.34 1.83e-8 IgG glycosylation; CESC cis rs9309711 0.621 rs7586472 chr2:3473670 G/A cg15506890 chr2:3487001 NA -0.43 -5.37 -0.31 1.7e-7 Neurofibrillary tangles; CESC cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg05347473 chr6:146136440 FBXO30 0.58 7.49 0.42 1.03e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7617480 0.648 rs9882443 chr3:48749064 G/A cg07636037 chr3:49044803 WDR6 0.75 9.52 0.5 1.15e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs4474465 1.000 rs12280198 chr11:78161361 C/T cg27205649 chr11:78285834 NARS2 -0.42 -5.19 -0.3 4.2e-7 Alzheimer's disease (survival time); CESC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg01874867 chr7:94954059 PON1 -0.43 -6.27 -0.36 1.44e-9 Paraoxonase activity; CESC cis rs11122272 0.733 rs2749700 chr1:231522734 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.22 -0.45 9.37e-15 Hemoglobin concentration; CESC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg00310523 chr12:86230176 RASSF9 0.38 5.72 0.33 2.8e-8 Major depressive disorder; CESC cis rs710216 0.917 rs900836 chr1:43412727 T/C cg22176566 chr1:43424700 SLC2A1 -0.5 -5.54 -0.32 7.23e-8 Red cell distribution width; CESC cis rs921968 0.643 rs522377 chr2:219437476 T/C cg02176678 chr2:219576539 TTLL4 0.41 7.08 0.4 1.27e-11 Mean corpuscular hemoglobin concentration; CESC cis rs67517081 1 rs67517081 chr16:30987380 GT/G cg02466173 chr16:30829666 NA 0.52 8.52 0.46 1.21e-15 Mean corpuscular hemoglobin; CESC cis rs7197653 0.748 rs11350 chr16:68335392 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -5.18 -0.3 4.42e-7 Magnesium levels; CESC trans rs10789640 1.000 rs1347913 chr11:96577720 A/G cg26796443 chr12:15844458 EPS8 0.44 6.01 0.35 6.01e-9 Immunoglobulin A vasculitis; CESC cis rs2832077 0.527 rs2250141 chr21:30241984 A/T cg24692254 chr21:30365293 RNF160 0.53 6.83 0.39 5.96e-11 Cognitive test performance; CESC cis rs3820068 0.608 rs2057304 chr1:16017710 A/G cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.64e-7 Systolic blood pressure; CESC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg25072359 chr17:41440525 NA 0.43 5.78 0.33 2.04e-8 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15708604 chr19:15490658 AKAP8 0.51 6.12 0.35 3.35e-9 Gut microbiome composition (summer); CESC cis rs8005677 1.000 rs4981449 chr14:23388871 C/G cg01529538 chr14:23388837 RBM23 0.51 6.87 0.39 4.64e-11 Cognitive ability (multi-trait analysis); CESC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg27170947 chr2:26402098 FAM59B -0.6 -7.09 -0.4 1.18e-11 Gut microbiome composition (summer); CESC cis rs34526934 0.608 rs7606110 chr2:177028551 T/C cg14324370 chr2:177042789 NA -0.5 -6.1 -0.35 3.65e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs2249694 0.572 rs9418984 chr10:135322356 C/G cg20169779 chr10:135381914 SYCE1 -0.42 -5.62 -0.33 4.72e-8 Obesity-related traits; CESC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg24399712 chr22:39784796 NA 0.81 10.69 0.55 2.13e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9487051 0.676 rs9374077 chr6:109600194 C/T cg12927641 chr6:109611667 NA -0.36 -5.43 -0.32 1.28e-7 Reticulocyte fraction of red cells; CESC cis rs67311347 1.000 rs9829800 chr3:40443927 T/C cg24209194 chr3:40518798 ZNF619 0.47 6.08 0.35 4.1e-9 Renal cell carcinoma; CESC cis rs6964587 1.000 rs6979085 chr7:91673623 C/T cg17063962 chr7:91808500 NA 0.58 7.89 0.44 8.08e-14 Breast cancer; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg12506373 chr2:27440548 CAD 0.59 6.13 0.35 3.15e-9 Diastolic blood pressure; CESC cis rs36051895 0.632 rs7850425 chr9:5170645 G/T cg02405213 chr9:5042618 JAK2 -0.51 -5.94 -0.34 8.91e-9 Pediatric autoimmune diseases; CESC trans rs11098499 0.866 rs12499602 chr4:120284387 T/A cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs2688608 0.592 rs7909544 chr10:75484004 G/C cg23231163 chr10:75533350 FUT11 -0.36 -5.42 -0.32 1.37e-7 Inflammatory bowel disease; CESC cis rs9303401 0.646 rs8067682 chr17:57219391 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.56 7.28 0.41 3.7e-12 Cognitive test performance; CESC cis rs950776 0.518 rs1504545 chr15:78818471 C/G cg24631222 chr15:78858424 CHRNA5 0.4 5.03 0.3 8.89e-7 Sudden cardiac arrest; CESC cis rs10899021 0.790 rs12280434 chr11:74332827 C/T cg25880958 chr11:74394337 NA -0.74 -7.95 -0.44 5.44e-14 Response to metformin (IC50); CESC cis rs9796 0.621 rs9972349 chr15:41491656 A/G cg20272979 chr15:41787780 ITPKA 0.35 5.25 0.31 3.11e-7 Menopause (age at onset); CESC cis rs7264396 0.790 rs6579255 chr20:34219496 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -11.94 -0.59 1.35e-26 Total cholesterol levels; CESC cis rs9896933 0.832 rs77512810 chr17:80804589 C/T cg20578329 chr17:80767326 TBCD -0.77 -8.12 -0.45 1.77e-14 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs9309473 0.950 rs10169213 chr2:73787234 G/C cg20560298 chr2:73613845 ALMS1 -0.53 -6.93 -0.39 3.19e-11 Metabolite levels; CESC cis rs910316 0.763 rs175016 chr14:75459633 C/T cg08847533 chr14:75593920 NEK9 -0.9 -15.8 -0.7 4.65e-40 Height; CESC cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg01579765 chr21:45077557 HSF2BP -0.56 -9.81 -0.52 1.43e-19 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07086847 chr8:145550618 DGAT1 0.61 7.1 0.4 1.15e-11 Gut microbiome composition (summer); CESC cis rs2204008 0.715 rs12815986 chr12:38343869 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.74 0.55 1.39e-22 Bladder cancer; CESC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg21782813 chr7:2030301 MAD1L1 0.53 7.58 0.42 5.68e-13 Bipolar disorder and schizophrenia; CESC cis rs3749237 0.595 rs17595772 chr3:49409704 G/A cg06212747 chr3:49208901 KLHDC8B 0.53 7.2 0.4 6.08e-12 Resting heart rate; CESC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg05872129 chr22:39784769 NA -0.85 -12.1 -0.6 3.94e-27 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25959527 chr3:195163920 ACAP2 -0.48 -6.26 -0.36 1.55e-9 Fibrinogen levels; CESC cis rs9905704 0.918 rs304282 chr17:56785571 T/C cg12560992 chr17:57184187 TRIM37 0.59 7.1 0.4 1.16e-11 Testicular germ cell tumor; CESC trans rs7335046 1.000 rs9517667 chr13:99915135 G/A cg14259717 chr11:18433732 LDHC 0.64 6.31 0.36 1.14e-9 Basal cell carcinoma; CESC cis rs12479064 0.703 rs28382977 chr2:100018304 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.82 -0.43 1.29e-13 Chronic sinus infection; CESC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC cis rs9399135 0.967 rs12661423 chr6:135349570 C/T cg24558204 chr6:135376177 HBS1L 0.55 7.74 0.43 2.05e-13 Red blood cell count; CESC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg19052272 chr2:3704530 ALLC -0.48 -5.86 -0.34 1.37e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg13114125 chr14:105738426 BRF1 -0.88 -10.98 -0.56 2.32e-23 Mean platelet volume;Platelet distribution width; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12035827 chr1:10855226 CASZ1 -0.45 -6.03 -0.35 5.51e-9 Fibrinogen levels; CESC cis rs853679 1.000 rs2799079 chr6:28235176 A/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.67 7.09 0.4 1.23e-11 Depression; CESC cis rs3733585 0.673 rs7376948 chr4:9954708 G/A cg00071950 chr4:10020882 SLC2A9 -0.69 -11.35 -0.57 1.36e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4132509 1.000 rs2168812 chr1:243777066 G/A cg21452805 chr1:244014465 NA 0.44 5.22 0.31 3.64e-7 RR interval (heart rate); CESC cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg01238044 chr22:24384105 GSTT1 -0.45 -5.56 -0.32 6.55e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs4716602 0.596 rs12386632 chr7:156158221 G/A cg07175507 chr18:77160758 NFATC1 -0.45 -6.14 -0.35 3e-9 Anti-saccade response; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09174674 chr1:9884042 CLSTN1 0.62 6.85 0.39 5.06e-11 Gut microbiome composition (summer); CESC cis rs2952156 0.920 rs2934956 chr17:37830447 T/A cg20243544 chr17:37824526 PNMT 0.63 8.11 0.45 1.92e-14 Asthma; CESC cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg03467027 chr4:99064603 C4orf37 0.48 6.01 0.35 6.26e-9 Colonoscopy-negative controls vs population controls; CESC cis rs568617 0.903 rs601863 chr11:65646557 C/A cg00576331 chr11:65640516 EFEMP2 0.45 5.3 0.31 2.48e-7 Crohn's disease; CESC cis rs8062405 0.824 rs28698667 chr16:28533071 C/T cg07382826 chr16:28625726 SULT1A1 0.31 5.05 0.3 8.32e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26593380 chr7:4749206 FOXK1 0.49 6.8 0.39 6.91e-11 Fibrinogen levels; CESC cis rs7503807 0.688 rs901060 chr17:78594990 G/A cg09596252 chr17:78655493 RPTOR 0.37 5.21 0.3 3.84e-7 Obesity; CESC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg21724239 chr8:58056113 NA 0.59 5.64 0.33 4.27e-8 Developmental language disorder (linguistic errors); CESC cis rs258892 0.895 rs2338792 chr5:72066860 G/C cg21869765 chr5:72125136 TNPO1 -0.43 -5.35 -0.31 1.93e-7 Small cell lung carcinoma; CESC cis rs1514687 0.534 rs11674407 chr2:1464530 G/C cg13703866 chr2:1479523 TPO -0.83 -5.33 -0.31 2.11e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs10751667 0.961 rs7396670 chr11:929269 A/G cg06064525 chr11:970664 AP2A2 -0.43 -7.7 -0.43 2.72e-13 Alzheimer's disease (late onset); CESC cis rs6541297 1.000 rs6665260 chr1:230279067 G/T cg20703242 chr1:230279135 GALNT2 0.68 10.87 0.56 5.47e-23 Coronary artery disease; CESC trans rs629535 0.821 rs660144 chr8:70035629 T/C cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs17655565 1.000 rs73309373 chr12:52701409 C/T cg08257133 chr12:52711352 KRT83 0.54 6.78 0.38 7.83e-11 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.21e-8 Lung cancer; CESC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg09658497 chr7:2847517 GNA12 -0.37 -5.1 -0.3 6.42e-7 Height; CESC cis rs17401966 0.838 rs12127604 chr1:10352800 T/G cg15208524 chr1:10270712 KIF1B 0.41 5.32 0.31 2.16e-7 Hepatocellular carcinoma; CESC cis rs2979489 0.838 rs2979513 chr8:30397925 G/C cg26383811 chr8:30366931 RBPMS -0.8 -9.99 -0.52 3.88e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs7605827 0.576 rs35785577 chr2:15659611 A/G cg19274914 chr2:15703543 NA 0.36 6.31 0.36 1.18e-9 Educational attainment (years of education); CESC cis rs79057730 0.599 rs6951032 chr7:794092 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.93 7.84 0.43 1.12e-13 Initial pursuit acceleration; CESC cis rs2742417 0.603 rs1962800 chr3:45779943 C/T cg04837898 chr3:45731254 SACM1L -0.54 -6.9 -0.39 3.84e-11 Response to anti-depressant treatment in major depressive disorder; CESC cis rs9467711 0.606 rs9379863 chr6:26372427 A/G cg12826209 chr6:26865740 GUSBL1 0.62 5.24 0.31 3.25e-7 Autism spectrum disorder or schizophrenia; CESC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg23048001 chr7:2026167 MAD1L1 0.47 6.17 0.35 2.48e-9 Bipolar disorder and schizophrenia; CESC cis rs7539409 0.604 rs910183 chr1:84297285 A/G cg10977910 chr1:84465055 TTLL7 0.75 7.16 0.4 7.79e-12 Alzheimer's disease; CESC cis rs17401966 1.000 rs4846210 chr1:10322153 A/G cg15208524 chr1:10270712 KIF1B 0.5 6.47 0.37 4.65e-10 Hepatocellular carcinoma; CESC cis rs250677 0.652 rs36045 chr5:148441184 A/G cg18129178 chr5:148520854 ABLIM3 0.58 6.03 0.35 5.58e-9 Breast cancer; CESC cis rs4843747 0.697 rs72818533 chr16:88073841 G/A cg06915872 chr16:87998081 BANP 0.49 5.83 0.34 1.62e-8 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14702927 chr19:46366445 FOXA3;SYMPK -0.49 -6.15 -0.35 2.79e-9 Ulcerative colitis; CESC cis rs12681288 0.676 rs2701927 chr8:995886 G/A cg15309053 chr8:964076 NA 0.42 7.18 0.4 6.95e-12 Schizophrenia; CESC cis rs7845219 0.506 rs12548999 chr8:95929843 C/T cg23172400 chr8:95962367 TP53INP1 -0.36 -6.63 -0.38 1.9e-10 Type 2 diabetes; CESC cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg00033643 chr7:134001901 SLC35B4 0.41 5.2 0.3 4e-7 Mean platelet volume; CESC cis rs4819052 0.851 rs2838867 chr21:46713092 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.71 8.95 0.48 6.48e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7070678 0.870 rs10826651 chr10:29814475 A/T cg06477056 chr5:175110609 HRH2 0.35 6.59 0.38 2.31e-10 Platelet thrombus formation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05102190 chr7:143078242 ZYX -0.42 -5.99 -0.35 6.66e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7561273 0.565 rs6545275 chr2:24331860 A/G cg06627628 chr2:24431161 ITSN2 -0.46 -5.42 -0.32 1.34e-7 Quantitative traits; CESC cis rs950169 0.512 rs4374136 chr15:84645007 C/G cg17507749 chr15:85114479 UBE2QP1 0.61 5.99 0.35 6.73e-9 Schizophrenia; CESC cis rs1215050 0.791 rs983187 chr4:98816350 A/T cg05340658 chr4:99064831 C4orf37 0.51 6.57 0.37 2.63e-10 Waist-to-hip ratio adjusted for body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08125682 chr16:11038455 CLEC16A -0.45 -6.35 -0.36 9.34e-10 Fibrinogen levels; CESC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs6831352 1.000 rs1126670 chr4:100052733 C/A cg12011299 chr4:100065546 ADH4 0.69 8.43 0.46 2.17e-15 Alcohol dependence; CESC cis rs9486719 0.857 rs1157316 chr6:96869710 G/A cg06623918 chr6:96969491 KIAA0776 0.89 10.34 0.54 2.9e-21 Migraine;Coronary artery disease; CESC cis rs5758511 0.773 rs10154700 chr22:42365073 G/T cg00645731 chr22:42541494 CYP2D7P1 0.36 5.07 0.3 7.65e-7 Birth weight; CESC cis rs977987 0.806 rs4888405 chr16:75428196 A/C cg03315344 chr16:75512273 CHST6 0.37 5.34 0.31 1.97e-7 Dupuytren's disease; CESC cis rs13720 0.722 rs163795 chr20:57577505 C/G cg23907860 chr20:57583709 CTSZ -0.43 -5.31 -0.31 2.33e-7 Platelet distribution width; CESC cis rs904092 0.786 rs62305755 chr4:100150020 G/A cg12011299 chr4:100065546 ADH4 0.54 6.09 0.35 3.89e-9 Alcohol dependence; CESC cis rs11630290 0.806 rs10519220 chr15:64047120 C/T cg12036633 chr15:63758958 NA 0.53 5.32 0.31 2.17e-7 Iris characteristics; CESC cis rs3020736 0.500 rs4147641 chr22:42482502 C/G cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC cis rs12325245 0.536 rs8058781 chr16:58653838 G/A cg01152986 chr16:58549298 SETD6 0.86 5.07 0.3 7.43e-7 Schizophrenia; CESC cis rs920590 0.684 rs59565447 chr8:19668430 A/T cg17834443 chr8:19674713 INTS10 0.59 6.51 0.37 3.66e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs2380220 0.935 rs7748857 chr6:96001887 A/G cg04719120 chr6:96025338 MANEA 0.51 5.04 0.3 8.77e-7 Behavioural disinhibition (generation interaction); CESC cis rs7523050 0.730 rs72984628 chr1:109460808 G/A cg08274380 chr1:109419600 GPSM2 0.79 5.91 0.34 1.04e-8 Fat distribution (HIV); CESC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg11663144 chr21:46675770 NA 0.46 6.01 0.35 6.01e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg18758796 chr5:131593413 PDLIM4 0.41 5.66 0.33 4e-8 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17169043 chr6:170863845 PSMB1;TBP 0.54 5.99 0.35 6.68e-9 Gut microbiome composition (summer); CESC cis rs6500602 0.673 rs4786512 chr16:4573040 A/G cg08645402 chr16:4508243 NA 0.43 6.47 0.37 4.77e-10 Schizophrenia; CESC cis rs1784581 0.588 rs7453474 chr6:162421736 C/T cg17173639 chr6:162384350 PARK2 0.57 8.73 0.47 2.94e-16 Itch intensity from mosquito bite; CESC cis rs17539620 0.519 rs4077066 chr6:154838448 C/G cg20019720 chr6:154832845 CNKSR3 0.43 6.26 0.36 1.52e-9 Lipoprotein (a) levels; CESC cis rs2180341 0.722 rs9388555 chr6:127576363 G/A cg27446573 chr6:127587934 RNF146 0.87 12.33 0.6 6.52e-28 Breast cancer; CESC cis rs34311866 0.808 rs11248059 chr4:960331 C/G cg07828340 chr4:882639 GAK 0.89 6.51 0.37 3.69e-10 Parkinson's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24441975 chr1:39339062 MYCBP -0.47 -6.23 -0.36 1.78e-9 Ulcerative colitis; CESC cis rs4561483 0.799 rs33635 chr16:11991944 C/T cg08843971 chr16:11963173 GSPT1 -0.41 -5.74 -0.33 2.62e-8 Testicular germ cell tumor; CESC cis rs9467711 0.606 rs12174602 chr6:26372827 C/T cg12826209 chr6:26865740 GUSBL1 0.63 5.37 0.31 1.7e-7 Autism spectrum disorder or schizophrenia; CESC cis rs2302190 0.882 rs9903173 chr17:56607358 C/T cg25885038 chr17:56607967 SEPT4 -0.41 -5.72 -0.33 2.91e-8 Vitamin D levels; CESC cis rs72634258 0.796 rs6703955 chr1:8165975 C/G cg00042356 chr1:8021962 PARK7 -0.47 -5.04 -0.3 8.61e-7 Inflammatory bowel disease; CESC cis rs728616 0.867 rs4520539 chr10:81740529 C/G cg05935833 chr10:81318306 SFTPA2 -0.52 -5.06 -0.3 7.72e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9911578 0.933 rs11868348 chr17:57179238 C/T cg05425664 chr17:57184151 TRIM37 -0.53 -7.31 -0.41 3.19e-12 Intelligence (multi-trait analysis); CESC cis rs6963495 0.818 rs73190167 chr7:105160418 A/G cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg05340658 chr4:99064831 C4orf37 0.69 9.38 0.5 3.07e-18 Colonoscopy-negative controls vs population controls; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg04590956 chr2:70057467 GMCL1 0.5 6.36 0.36 8.73e-10 Obesity-related traits; CESC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg18240062 chr17:79603768 NPLOC4 0.54 7.05 0.4 1.56e-11 Eye color traits; CESC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg24531977 chr5:56204891 C5orf35 0.91 12.2 0.6 1.8e-27 Initial pursuit acceleration; CESC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.57 0.32 6.31e-8 Bipolar disorder; CESC cis rs1348850 0.793 rs13000048 chr2:178337089 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.74 10.26 0.53 4.96e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1003719 0.788 rs1543748 chr21:38446581 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.7 0.47 3.48e-16 Eye color traits; CESC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg00166722 chr3:10149974 C3orf24 0.53 6.65 0.38 1.64e-10 Alzheimer's disease; CESC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg12463550 chr7:65579703 CRCP 0.49 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs1062746 0.683 rs891094 chr16:87378001 C/G cg02258303 chr16:87377426 FBXO31 0.5 6.31 0.36 1.2e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CESC cis rs9467773 0.901 rs1407045 chr6:26476155 A/G cg11502198 chr6:26597334 ABT1 0.4 5.46 0.32 1.12e-7 Intelligence (multi-trait analysis); CESC cis rs11203032 0.831 rs10887925 chr10:90938902 G/T cg16672925 chr10:90967113 CH25H 0.72 7.17 0.4 7.66e-12 Heart failure; CESC cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg12365402 chr11:9010492 NRIP3 -0.32 -5.24 -0.31 3.31e-7 Hemoglobin concentration; CESC cis rs2603127 0.768 rs9864741 chr3:108489823 G/A cg03329597 chr3:108125523 MYH15 0.6 5.38 0.31 1.63e-7 Hemostatic factors and hematological phenotypes; CESC cis rs7208859 0.623 rs75136574 chr17:28934549 C/A cg13385521 chr17:29058706 SUZ12P 0.78 5.67 0.33 3.78e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1062177 1.000 rs62394155 chr5:151248069 G/A cg00977110 chr5:151150581 G3BP1 0.63 6.59 0.38 2.35e-10 Preschool internalizing problems; CESC cis rs738322 0.775 rs4375 chr22:38539041 T/C cg25457927 chr22:38595422 NA -0.28 -5.18 -0.3 4.37e-7 Cutaneous nevi; CESC cis rs9325144 0.624 rs10783333 chr12:39118931 A/T cg26384229 chr12:38710491 ALG10B 0.53 7.39 0.41 1.94e-12 Morning vs. evening chronotype; CESC cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7662987 0.793 rs12697 chr4:99993376 C/T cg13256891 chr4:100009986 ADH5 0.59 5.18 0.3 4.35e-7 Smoking initiation; CESC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg21984481 chr17:79567631 NPLOC4 -0.35 -5.41 -0.32 1.43e-7 Eye color traits; CESC cis rs7247513 0.639 rs12984441 chr19:12760287 A/C cg11738485 chr19:12877000 HOOK2 0.48 6.05 0.35 4.86e-9 Bipolar disorder; CESC cis rs17125944 0.615 rs12587286 chr14:53304751 C/T cg00686598 chr14:53173677 PSMC6 1.09 8.28 0.45 6.22e-15 Alzheimer's disease (late onset); CESC cis rs735860 0.737 rs2397139 chr6:53150804 C/G cg10236188 chr6:53219634 NA -0.34 -5.1 -0.3 6.53e-7 Glaucoma; CESC cis rs11122272 0.735 rs2790891 chr1:231513190 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19741408 chr1:90460434 ZNF326;LOC492303 0.46 6.15 0.35 2.91e-9 Systemic lupus erythematosus; CESC cis rs7845219 0.544 rs7016078 chr8:95922615 G/A cg23172400 chr8:95962367 TP53INP1 -0.38 -7.19 -0.4 6.78e-12 Type 2 diabetes; CESC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg22823121 chr1:150693482 HORMAD1 0.47 6.48 0.37 4.52e-10 Melanoma; CESC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg03609598 chr5:56110824 MAP3K1 -0.5 -5.45 -0.32 1.15e-7 Initial pursuit acceleration; CESC cis rs6688613 0.694 rs12062326 chr1:166820186 G/A ch.1.3259774R chr1:166827647 TADA1 0.58 5.86 0.34 1.38e-8 Refractive astigmatism; CESC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg26314531 chr2:26401878 FAM59B -0.83 -9.14 -0.49 1.64e-17 Gut microbiome composition (summer); CESC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.78 0.33 2.12e-8 Tonsillectomy; CESC cis rs7903847 0.642 rs7903562 chr10:99154782 T/C cg20016023 chr10:99160130 RRP12 -0.29 -5.06 -0.3 7.87e-7 Granulocyte percentage of myeloid white cells; CESC cis rs4604732 0.631 rs10802509 chr1:247627158 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9399401 0.626 rs13198644 chr6:142783233 A/G cg03128060 chr6:142623767 GPR126 0.3 5.03 0.3 8.92e-7 Chronic obstructive pulmonary disease; CESC cis rs12824058 0.831 rs12297939 chr12:130811923 G/C cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg10691866 chr7:65817282 TPST1 0.33 5.51 0.32 8.51e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09360458 chr1:14075560 PRDM2 -0.6 -7.05 -0.4 1.51e-11 Gut microbiome composition (summer); CESC cis rs7903847 0.596 rs9787426 chr10:99155327 A/G cg20016023 chr10:99160130 RRP12 -0.3 -5.16 -0.3 4.77e-7 Granulocyte percentage of myeloid white cells; CESC cis rs7927592 0.913 rs4084149 chr11:68288567 A/G cg20283391 chr11:68216788 NA -0.62 -7.54 -0.42 7.69e-13 Total body bone mineral density; CESC cis rs72781680 0.898 rs2339851 chr2:23938883 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.91 0.39 3.5e-11 Lymphocyte counts; CESC cis rs8017423 0.967 rs7150093 chr14:90724661 C/T cg14092571 chr14:90743983 NA 0.54 8.12 0.45 1.74e-14 Mortality in heart failure; CESC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg06028808 chr11:68637592 NA 0.47 5.47 0.32 1.03e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs662064 0.544 rs12725704 chr1:10613351 T/C cg20482658 chr1:10539492 PEX14 0.34 5.55 0.32 7.02e-8 Asthma; CESC cis rs9815354 0.951 rs9864331 chr3:41762217 G/A cg03022575 chr3:42003672 ULK4 0.51 5.1 0.3 6.62e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs2629540 0.781 rs2293064 chr10:126396511 C/G cg08799069 chr10:126477246 METTL10 0.47 6.06 0.35 4.75e-9 Cocaine dependence; CESC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg18032046 chr6:28092343 ZSCAN16 0.5 5.85 0.34 1.41e-8 Depression; CESC cis rs733592 0.524 rs10875726 chr12:48425992 A/G cg04545296 chr12:48745243 ZNF641 -0.29 -5.46 -0.32 1.07e-7 Plateletcrit; CESC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg24060327 chr5:131705240 SLC22A5 -0.78 -10.93 -0.56 3.25e-23 Breast cancer; CESC cis rs4642101 0.597 rs9865624 chr3:12822786 T/A cg05775895 chr3:12838266 CAND2 0.39 5.93 0.34 9.32e-9 QRS complex (12-leadsum); CESC cis rs1270639 0.778 rs2707942 chr7:157445750 G/C cg13357408 chr7:157437802 PTPRN2 0.62 7.26 0.41 4.32e-12 Colorectal cancer; CESC cis rs6502050 0.835 rs62078304 chr17:80085224 G/A cg11859384 chr17:80120422 CCDC57 0.38 5.13 0.3 5.62e-7 Life satisfaction; CESC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg02725872 chr8:58115012 NA -0.46 -7.13 -0.4 9.4e-12 Developmental language disorder (linguistic errors); CESC cis rs367615 0.506 rs1428932 chr5:108792479 A/G cg17395555 chr5:108820864 NA -0.58 -9.89 -0.52 7.61e-20 Colorectal cancer (SNP x SNP interaction); CESC cis rs12900413 0.603 rs12906832 chr15:90301314 C/G cg24249390 chr15:90295951 MESP1 -0.4 -5.4 -0.31 1.52e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg22974920 chr21:40686053 BRWD1 -0.45 -5.55 -0.32 6.91e-8 Cognitive function; CESC cis rs10492096 0.947 rs61918022 chr12:6614521 C/T cg13857086 chr12:6580257 VAMP1 0.61 6.04 0.35 5.24e-9 Hip geometry; CESC cis rs3815700 1.000 rs2287670 chr19:33095057 G/A cg02997394 chr19:33096574 ANKRD27 0.71 7.07 0.4 1.39e-11 Eosinophilic esophagitis; CESC cis rs3540 0.553 rs2158406 chr15:90994499 T/C cg22089800 chr15:90895588 ZNF774 0.64 8.76 0.47 2.32e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg09658497 chr7:2847517 GNA12 -0.36 -5.42 -0.32 1.32e-7 Height; CESC cis rs763121 0.853 rs6001188 chr22:39062194 T/C cg06022373 chr22:39101656 GTPBP1 0.91 14.85 0.67 1.02e-36 Menopause (age at onset); CESC cis rs3820928 0.874 rs3752896 chr2:227886925 C/T cg05526886 chr2:227700861 RHBDD1 -0.43 -5.49 -0.32 9.36e-8 Pulmonary function; CESC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.48 0.37 4.52e-10 Prudent dietary pattern; CESC trans rs7615952 0.688 rs12638224 chr3:125541320 C/T cg07211511 chr3:129823064 LOC729375 -0.84 -9.55 -0.51 9.43e-19 Blood pressure (smoking interaction); CESC cis rs8070740 0.841 rs4790771 chr17:5324966 G/T cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.35 0.36 9.3e-10 Menopause (age at onset); CESC cis rs2243480 1.000 rs781142 chr7:65438778 C/T cg25894440 chr7:65020034 NA -0.63 -5.61 -0.33 5.13e-8 Diabetic kidney disease; CESC cis rs4566357 0.615 rs10184991 chr2:227916533 G/A cg05526886 chr2:227700861 RHBDD1 -0.51 -6.67 -0.38 1.53e-10 Coronary artery disease; CESC cis rs11098499 0.738 rs28687057 chr4:120280812 A/G cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.96e-10 Bipolar disorder; CESC cis rs56775891 1.000 rs34945223 chr18:77575871 A/G cg13263691 chr18:77568018 NA 0.5 7.31 0.41 3.06e-12 Schizophrenia; CESC cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg10556349 chr10:835070 NA 0.53 5.71 0.33 2.99e-8 Eosinophil percentage of granulocytes; CESC cis rs35110281 0.744 rs230645 chr21:44918607 A/G cg21573476 chr21:45109991 RRP1B 0.4 5.7 0.33 3.15e-8 Mean corpuscular volume; CESC cis rs6831352 0.918 rs17817359 chr4:100054197 G/T cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs748404 0.660 rs690512 chr15:43717678 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.55 0.42 7.19e-13 Lung cancer; CESC trans rs1814175 0.630 rs1722019 chr11:49904102 G/A cg03929089 chr4:120376271 NA -0.71 -9.17 -0.49 1.39e-17 Height; CESC cis rs1878931 0.582 rs27232 chr16:3436782 G/A cg02880119 chr16:3481970 NA 0.41 5.25 0.31 3.12e-7 Body mass index (adult); CESC cis rs950169 0.840 rs4842853 chr15:84942304 G/T cg17507749 chr15:85114479 UBE2QP1 0.59 6.52 0.37 3.46e-10 Schizophrenia; CESC trans rs3780486 0.846 rs4584234 chr9:33147479 G/A cg04842962 chr6:43655489 MRPS18A 0.96 17.4 0.73 9.89e-46 IgG glycosylation; CESC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg16325326 chr1:53192061 ZYG11B -0.98 -17.51 -0.73 3.83e-46 Monocyte count; CESC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg12963246 chr6:28129442 ZNF389 0.57 7.78 0.43 1.65e-13 Depression; CESC cis rs9300255 0.596 rs11057202 chr12:123720775 G/T cg00376283 chr12:123451042 ABCB9 0.67 9.05 0.49 3.14e-17 Neutrophil percentage of white cells; CESC cis rs11122272 0.705 rs2486742 chr1:231507254 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.03 -0.4 1.77e-11 Hemoglobin concentration; CESC cis rs34734847 0.703 rs7978125 chr12:121167039 A/G cg26008908 chr12:120799332 MSI1 0.33 5.23 0.31 3.4e-7 Mean corpuscular volume; CESC cis rs79976124 0.837 rs11751994 chr6:66644028 A/C cg07460842 chr6:66804631 NA 0.71 8.33 0.46 4.36e-15 Type 2 diabetes; CESC trans rs1814175 0.935 rs11040465 chr11:49689323 C/T cg03929089 chr4:120376271 NA -0.85 -12.76 -0.62 2.21e-29 Height; CESC trans rs2235573 0.653 rs3026670 chr22:38426774 T/C cg19894588 chr14:64061835 NA 0.49 6.37 0.36 8.46e-10 Glioblastoma;Glioma; CESC cis rs17021463 0.676 rs17311887 chr4:95313228 T/C cg11021082 chr4:95130006 SMARCAD1 0.52 7.09 0.4 1.2e-11 Testicular germ cell tumor; CESC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03352830 chr11:487213 PTDSS2 -0.69 -6.76 -0.38 8.81e-11 Body mass index; CESC trans rs561341 1.000 rs546748 chr17:30324293 A/C cg27661571 chr11:113659931 NA -0.55 -6.25 -0.36 1.67e-9 Hip circumference adjusted for BMI; CESC cis rs5769707 0.749 rs7286706 chr22:50058346 G/C cg05373962 chr22:49881684 NA -0.36 -6.39 -0.37 7.36e-10 Monocyte count;Monocyte percentage of white cells; CESC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg08888203 chr3:10149979 C3orf24 0.5 6.38 0.37 7.71e-10 Alzheimer's disease; CESC cis rs9815354 0.812 rs73071338 chr3:41824328 G/A cg03022575 chr3:42003672 ULK4 0.7 6.2 0.36 2.11e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs113835537 0.529 rs11227500 chr11:66273233 T/C cg22134325 chr11:66188745 NPAS4 0.35 5.57 0.32 6.18e-8 Airway imaging phenotypes; CESC cis rs4862750 0.872 rs7664463 chr4:187876686 A/C cg07414643 chr4:187882934 NA 0.48 6.84 0.39 5.59e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg26314531 chr2:26401878 FAM59B 0.81 8.6 0.47 7.16e-16 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05996236 chr5:178286857 ZNF354B 0.62 6.7 0.38 1.24e-10 Gut microbiome composition (summer); CESC cis rs2635047 0.777 rs9944807 chr18:44788908 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.34 0.31 2e-7 Educational attainment; CESC cis rs60843830 0.517 rs58416198 chr2:175580 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.62 6.91 0.39 3.66e-11 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs6964587 1.000 rs10280927 chr7:91582205 G/A cg17063962 chr7:91808500 NA -0.57 -7.68 -0.43 3.06e-13 Breast cancer; CESC cis rs7107174 0.892 rs4945265 chr11:78027458 G/A cg02023728 chr11:77925099 USP35 0.48 6.41 0.37 6.64e-10 Testicular germ cell tumor; CESC cis rs3857067 0.806 rs17302467 chr4:95112056 T/C cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC cis rs258892 0.895 rs155427 chr5:72115763 A/G cg21869765 chr5:72125136 TNPO1 -0.44 -5.65 -0.33 4.05e-8 Small cell lung carcinoma; CESC cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg00033643 chr7:134001901 SLC35B4 0.44 5.66 0.33 3.97e-8 Mean platelet volume; CESC cis rs9858542 0.953 rs6446272 chr3:49463287 G/A cg07274523 chr3:49395745 GPX1 0.67 8.23 0.45 8.41e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg02269571 chr22:50332266 NA -0.57 -6.99 -0.39 2.29e-11 Schizophrenia; CESC cis rs703842 0.616 rs1875125 chr12:58227241 T/G cg04478727 chr12:58166393 METTL1;FAM119B 0.58 6.82 0.39 5.98e-11 Multiple sclerosis; CESC cis rs10242455 0.702 rs115279860 chr7:98994492 C/T cg18809830 chr7:99032528 PTCD1 -0.83 -5.55 -0.32 6.86e-8 Blood metabolite levels; CESC cis rs8067354 0.872 rs7224006 chr17:57896338 C/T cg02344993 chr17:57696989 CLTC -0.48 -6.15 -0.35 2.86e-9 Hemoglobin concentration; CESC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.81 0.39 6.45e-11 Bipolar disorder; CESC cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg02487422 chr3:49467188 NICN1 0.4 5.15 0.3 5.11e-7 Parkinson's disease; CESC cis rs9814567 0.752 rs7633868 chr3:134331048 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.09 -0.3 6.84e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg07414643 chr4:187882934 NA 0.54 7.55 0.42 6.98e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18992706 chr13:44453352 CCDC122;C13orf31 -0.45 -6.04 -0.35 5.15e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9911578 0.967 rs11079354 chr17:56594460 G/A cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.5e-11 Intelligence (multi-trait analysis); CESC cis rs6912958 0.535 rs1753154 chr6:88032843 G/C cg04972856 chr6:88032051 C6orf162;GJB7 0.32 5.18 0.3 4.43e-7 Monocyte percentage of white cells; CESC cis rs977987 0.741 rs10514393 chr16:75344476 C/T cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.77e-8 Dupuytren's disease; CESC cis rs9443189 0.526 rs10943250 chr6:76208445 C/G cg01950844 chr6:76311363 SENP6 0.77 8.12 0.45 1.79e-14 Prostate cancer; CESC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs4253772 0.530 rs715518 chr22:46754177 C/G cg00784671 chr22:46762841 CELSR1 -0.64 -6.12 -0.35 3.28e-9 LDL cholesterol;Cholesterol, total; CESC cis rs2559856 1.000 rs2695288 chr12:102088112 T/C cg12213457 chr12:102090980 CHPT1 -0.36 -5.34 -0.31 2.02e-7 Blood protein levels; CESC cis rs2361710 0.611 rs12051781 chr17:78074468 A/G cg06718696 chr17:78121285 EIF4A3 0.61 7.35 0.41 2.49e-12 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21685663 chr1:154245266 HAX1 0.57 6.05 0.35 4.85e-9 Gut microbiome composition (summer); CESC cis rs9300255 0.537 rs1618679 chr12:123650714 A/G cg05973401 chr12:123451056 ABCB9 0.5 5.81 0.34 1.79e-8 Neutrophil percentage of white cells; CESC cis rs11203032 0.831 rs7074977 chr10:90948409 C/T cg16672925 chr10:90967113 CH25H 0.44 5.06 0.3 7.68e-7 Heart failure; CESC cis rs3733585 0.699 rs7683283 chr4:9969974 T/C cg11266682 chr4:10021025 SLC2A9 -0.58 -11.05 -0.56 1.37e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2559856 1.000 rs2695285 chr12:102089043 G/A cg12213457 chr12:102090980 CHPT1 -0.37 -5.56 -0.32 6.46e-8 Blood protein levels; CESC cis rs9815354 0.953 rs1716694 chr3:41986399 G/T cg03022575 chr3:42003672 ULK4 -0.44 -5.17 -0.3 4.69e-7 Pulse pressure;Diastolic blood pressure; CESC trans rs1908814 0.516 rs7812563 chr8:11794488 T/G cg15556689 chr8:8085844 FLJ10661 0.5 6.18 0.35 2.46e-9 Neuroticism; CESC cis rs2933343 0.700 rs789240 chr3:128630635 T/C cg11901034 chr3:128598214 ACAD9 -0.39 -5.71 -0.33 3.1e-8 IgG glycosylation; CESC cis rs17376456 0.741 rs10036829 chr5:93309897 G/C cg25358565 chr5:93447407 FAM172A 1.07 10.61 0.55 3.7e-22 Diabetic retinopathy; CESC cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7098414 0.511 rs12262228 chr10:82160425 C/T cg00277334 chr10:82204260 NA -0.52 -7.68 -0.43 3.1400000000000003e-13 Post bronchodilator FEV1; CESC trans rs17685 0.753 rs1639617 chr7:75701728 A/G cg19862616 chr7:65841803 NCRNA00174 0.87 12.7 0.62 3.58e-29 Coffee consumption;Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11296937 chr11:64084966 PRDX5;TRMT112 0.53 6.3 0.36 1.25e-9 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 12.19 0.6 2.01e-27 Alzheimer's disease; CESC cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.39 0.31 1.59e-7 Personality dimensions; CESC cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.44 0.32 1.2e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.64 0.38 1.82e-10 Bipolar disorder; CESC cis rs761746 0.960 rs3818134 chr22:31926725 C/T cg25791279 chr22:32026902 PISD -0.54 -6.28 -0.36 1.41e-9 Intelligence; CESC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg13628971 chr7:2884303 GNA12 0.64 8.52 0.46 1.18e-15 Height; CESC cis rs6484504 0.576 rs208093 chr11:31184400 C/T cg14844989 chr11:31128820 NA 0.4 5.34 0.31 1.96e-7 Red blood cell count; CESC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.45 5.98 0.34 7.23e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7605827 0.930 rs12989038 chr2:15549862 A/T cg19274914 chr2:15703543 NA 0.33 5.94 0.34 8.8e-9 Educational attainment (years of education); CESC cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg16339924 chr4:17578868 LAP3 0.61 7.65 0.43 3.64e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg20588892 chr5:87565114 TMEM161B 0.46 6.04 0.35 5.27e-9 Weight; CESC cis rs10751667 0.666 rs7396677 chr11:958878 C/T cg06064525 chr11:970664 AP2A2 -0.47 -9.35 -0.5 3.78e-18 Alzheimer's disease (late onset); CESC cis rs2984613 1 rs2984613 chr1:156197380 C/T cg25208724 chr1:156163844 SLC25A44 0.84 13.14 0.63 1.08e-30 Intracerebral hemorrhage;White matter hyperintensity burden; CESC cis rs11190604 1.000 rs2273694 chr10:102256496 G/T cg07080220 chr10:102295463 HIF1AN 0.66 6.37 0.36 8.35e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs1499614 0.901 rs3936 chr7:66126489 C/T cg18252515 chr7:66147081 NA -1.42 -14.43 -0.66 3.04e-35 Gout; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg20284440 chr14:52118688 FRMD6 0.48 6.87 0.39 4.5e-11 Systemic lupus erythematosus; CESC cis rs9811920 0.683 rs1718235 chr3:99583484 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -6.32 -0.36 1.13e-9 Axial length; CESC cis rs2295359 1.000 rs11209006 chr1:67619259 T/G cg03340356 chr1:67600835 NA 0.3 5.04 0.3 8.52e-7 Psoriasis; CESC cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs4595586 0.505 rs11613808 chr12:39390823 T/A cg26384229 chr12:38710491 ALG10B 0.63 8.92 0.48 7.92e-17 Morning vs. evening chronotype; CESC cis rs6728642 0.908 rs7588921 chr2:98021001 C/T cg26665480 chr2:98280029 ACTR1B -0.76 -6.65 -0.38 1.62e-10 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs611744 0.625 rs11991891 chr8:109294858 G/A cg21045802 chr8:109455806 TTC35 0.56 6.96 0.39 2.67e-11 Dupuytren's disease; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09730672 chr8:86157838 CA13 -0.44 -6.22 -0.36 1.95e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs11822910 0.724 rs7106223 chr11:57190448 A/G cg00522883 chr11:57194120 SLC43A3 -0.6 -5.92 -0.34 9.82e-9 Platelet distribution width; CESC cis rs9487051 0.735 rs419106 chr6:109520067 C/G cg01475377 chr6:109611718 NA -0.37 -5.55 -0.32 6.76e-8 Reticulocyte fraction of red cells; CESC cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg03146154 chr1:46216737 IPP -0.44 -5.49 -0.32 9.48e-8 High light scatter reticulocyte count; CESC cis rs7659604 0.521 rs4833773 chr4:122689245 C/T cg19671926 chr4:122722719 EXOSC9 0.65 8.55 0.47 9.68e-16 Type 2 diabetes; CESC cis rs10089 1.000 rs1962291 chr5:127445373 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.8 -10.95 -0.56 2.93e-23 Ileal carcinoids; CESC cis rs6736093 0.966 rs11682629 chr2:112744299 G/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.45 -0.32 1.17e-7 Coronary artery disease; CESC cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg05340658 chr4:99064831 C4orf37 0.8 12.36 0.6 5.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs3015497 0.537 rs3015470 chr14:51155787 A/G cg26011998 chr14:51135199 SAV1 -0.52 -5.85 -0.34 1.46e-8 Mean platelet volume; CESC cis rs7607369 0.536 rs12623740 chr2:219665715 T/A cg02176678 chr2:219576539 TTLL4 -0.36 -6.26 -0.36 1.58e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs6598955 0.671 rs12090258 chr1:26644698 C/T cg19743891 chr1:26644573 UBXN11;CD52 0.35 5.09 0.3 6.68e-7 Obesity-related traits; CESC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg26818010 chr10:134567672 INPP5A -0.85 -10.26 -0.53 5.27e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs16867321 0.950 rs12472841 chr2:181491840 C/A cg23363182 chr2:181467187 NA -0.42 -5.61 -0.33 5.02e-8 Obesity; CESC cis rs17641971 0.645 rs4873099 chr8:50025683 G/T cg00325661 chr8:49890786 NA 0.38 5.35 0.31 1.9e-7 Blood metabolite levels; CESC cis rs2115630 0.653 rs61394864 chr15:85170174 T/C cg12501888 chr15:85177176 SCAND2 -0.5 -6.62 -0.38 1.95e-10 P wave terminal force; CESC cis rs9291683 0.509 rs6849717 chr4:9958719 T/C cg02734326 chr4:10020555 SLC2A9 -0.48 -7.11 -0.4 1.05e-11 Bone mineral density; CESC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.62 0.64 2.27e-32 Prudent dietary pattern; CESC cis rs4237845 0.551 rs116263297 chr12:58273445 A/C cg02175503 chr12:58329896 NA 0.51 6.12 0.35 3.33e-9 Intelligence (multi-trait analysis); CESC cis rs6493487 0.512 rs117335843 chr15:51314455 C/G cg02338191 chr15:51200825 AP4E1 0.59 5.39 0.31 1.56e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg22903657 chr4:1355424 KIAA1530 -0.4 -5.67 -0.33 3.82e-8 Obesity-related traits; CESC cis rs9611519 0.780 rs3171692 chr22:41642212 C/T cg03806693 chr22:41940476 POLR3H -0.72 -7.8 -0.43 1.46e-13 Neuroticism; CESC trans rs2727020 0.688 rs4929894 chr11:49196333 G/C cg03929089 chr4:120376271 NA -0.78 -11.59 -0.58 2.11e-25 Coronary artery disease; CESC cis rs6456156 0.586 rs7761977 chr6:167485678 A/G cg23791538 chr6:167370224 RNASET2 -0.5 -6.37 -0.36 8.51e-10 Primary biliary cholangitis; CESC cis rs2832191 1.000 rs2832185 chr21:30483761 C/G cg24692254 chr21:30365293 RNF160 -0.7 -10.47 -0.54 1.09e-21 Dental caries; CESC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg21963583 chr11:68658836 MRPL21 0.41 5.57 0.32 6.29e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg03647317 chr4:187891568 NA -0.39 -5.84 -0.34 1.49e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs2997447 0.655 rs55820521 chr1:26374286 C/T cg19633962 chr1:26362018 EXTL1 -0.58 -5.66 -0.33 4.02e-8 QRS complex (12-leadsum); CESC cis rs921968 0.565 rs755112 chr2:219606052 C/T cg02176678 chr2:219576539 TTLL4 -0.46 -8.21 -0.45 9.84e-15 Mean corpuscular hemoglobin concentration; CESC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs2735413 0.709 rs8051521 chr16:78088156 G/C cg04733911 chr16:78082701 NA 0.53 8.56 0.47 9.02e-16 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7552167 1.000 rs59960858 chr1:24519437 C/A cg01960748 chr1:24522592 NA 0.49 6.35 0.36 9.35e-10 Psoriasis vulgaris; CESC cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg20891283 chr12:69753455 YEATS4 0.9 14.78 0.67 1.84e-36 Blood protein levels; CESC cis rs454510 0.816 rs347904 chr1:120177620 C/T cg16322792 chr1:120165303 ZNF697 0.45 7.12 0.4 1.01e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs977987 0.806 rs56343285 chr16:75409797 A/G cg03315344 chr16:75512273 CHST6 0.4 5.72 0.33 2.88e-8 Dupuytren's disease; CESC cis rs5747327 0.874 rs5747329 chr22:18170207 A/G cg19898043 chr22:18121309 BCL2L13 -0.42 -5.31 -0.31 2.34e-7 Myeloid white cell count;Granulocyte count; CESC cis rs9611565 0.659 rs169361 chr22:41877989 A/G cg03806693 chr22:41940476 POLR3H 1.21 14.96 0.68 4.35e-37 Vitiligo; CESC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg19774624 chr17:42201019 HDAC5 -0.68 -9.83 -0.52 1.21e-19 Total body bone mineral density; CESC cis rs9488822 0.676 rs13194714 chr6:116394819 T/A cg26893134 chr6:116381904 FRK 0.25 6.15 0.35 2.83e-9 Cholesterol, total;LDL cholesterol; CESC cis rs2710642 0.611 rs11125941 chr2:62880818 A/C cg17519650 chr2:63277830 OTX1 0.49 5.78 0.33 2.11e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs6088580 0.543 rs4911158 chr20:33239512 T/C cg08999081 chr20:33150536 PIGU -0.43 -6.17 -0.35 2.49e-9 Glomerular filtration rate (creatinine); CESC cis rs977987 0.843 rs62062568 chr16:75445324 T/C cg03315344 chr16:75512273 CHST6 0.4 5.83 0.34 1.57e-8 Dupuytren's disease; CESC cis rs2230307 0.505 rs571579 chr1:100617372 G/A cg24955406 chr1:100503596 HIAT1 -0.49 -5.18 -0.3 4.35e-7 Carotid intima media thickness; CESC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg04369109 chr6:150039330 LATS1 -0.41 -5.81 -0.34 1.82e-8 Lung cancer; CESC cis rs2404602 0.647 rs11072618 chr15:77019342 A/G cg23625390 chr15:77176239 SCAPER -0.4 -5.2 -0.3 4e-7 Blood metabolite levels; CESC cis rs910316 1.000 rs175443 chr14:75601963 C/T cg08847533 chr14:75593920 NEK9 -0.96 -17.98 -0.74 8.46e-48 Height; CESC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.42 0.32 1.34e-7 Major depressive disorder; CESC cis rs35110281 0.633 rs4819292 chr21:45125223 A/G cg04455712 chr21:45112962 RRP1B 0.49 7.76 0.43 1.9e-13 Mean corpuscular volume; CESC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg00784671 chr22:46762841 CELSR1 -0.48 -5.52 -0.32 7.99e-8 LDL cholesterol;Cholesterol, total; CESC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg18876405 chr7:65276391 NA -0.57 -7.75 -0.43 1.97e-13 Aortic root size; CESC cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg21573476 chr21:45109991 RRP1B -0.57 -8.59 -0.47 7.81e-16 Mean corpuscular volume; CESC cis rs3617 0.652 rs60332615 chr3:52867595 C/A cg11645453 chr3:52864694 ITIH4 -0.26 -5.19 -0.3 4.13e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg03352830 chr11:487213 PTDSS2 0.7 6.71 0.38 1.16e-10 Body mass index; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg06408034 chr1:45671987 ZSWIM5 -0.49 -6.4 -0.37 7.19e-10 Height; CESC cis rs10927875 0.632 rs7535248 chr1:16129598 C/T cg05821634 chr1:16164109 FLJ37453 0.35 5.08 0.3 6.97e-7 Dilated cardiomyopathy; CESC cis rs910316 0.712 rs175037 chr14:75465038 T/C cg08847533 chr14:75593920 NEK9 -0.9 -15.84 -0.7 3.34e-40 Height; CESC cis rs12142240 0.698 rs72677600 chr1:46834449 G/A cg00530320 chr1:46809349 NSUN4 0.63 8.16 0.45 1.33e-14 Menopause (age at onset); CESC cis rs7208859 0.623 rs59029591 chr17:29235746 A/C cg19761014 chr17:28927070 LRRC37B2 0.71 5.63 0.33 4.48e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg11644478 chr21:40555479 PSMG1 0.61 8.28 0.45 6.17e-15 Cognitive function; CESC trans rs7326068 0.610 rs7990231 chr13:21337838 C/T cg00192819 chr18:76486611 NA 0.43 6.13 0.35 3.11e-9 Schizophrenia, bipolar disorder and depression (combined); CESC cis rs3106136 0.527 rs2883 chr4:95158610 A/T cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.57 -0.58 2.49e-25 Capecitabine sensitivity; CESC cis rs11648796 0.765 rs2003832 chr16:769538 G/A cg27144592 chr16:783916 NARFL 0.5 6.46 0.37 5.09e-10 Height; CESC cis rs9467711 0.606 rs9348712 chr6:26366511 T/A cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.59e-7 Autism spectrum disorder or schizophrenia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15057251 chr18:32621312 MAPRE2 0.51 7.13 0.4 9.36e-12 Systemic lupus erythematosus; CESC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.63 7.65 0.43 3.8e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg11366901 chr6:160182831 ACAT2 0.76 9.68 0.51 3.64e-19 Age-related macular degeneration (geographic atrophy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18145393 chr4:520203 PIGG -0.64 -6.83 -0.39 5.71e-11 Gut microbiome composition (summer); CESC cis rs2361718 0.527 rs7211994 chr17:78152514 A/G cg06718696 chr17:78121285 EIF4A3 -0.49 -6.71 -0.38 1.2e-10 Yeast infection; CESC cis rs4664308 1.000 rs17831191 chr2:160911332 T/C cg03641300 chr2:160917029 PLA2R1 -0.68 -10.17 -0.53 9.82e-21 Idiopathic membranous nephropathy; CESC cis rs939658 0.805 rs6495374 chr15:79434031 C/T cg17916960 chr15:79447300 NA -0.36 -6.06 -0.35 4.67e-9 Refractive error; CESC cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs67311347 1.000 rs12633431 chr3:40505740 C/T cg09455208 chr3:40491958 NA -0.48 -8.14 -0.45 1.52e-14 Renal cell carcinoma; CESC cis rs17253792 0.732 rs75796044 chr14:56034128 C/T cg01858014 chr14:56050164 KTN1 -0.82 -6.56 -0.37 2.83e-10 Putamen volume; CESC cis rs7666738 0.830 rs1813972 chr4:98886828 C/A cg17366294 chr4:99064904 C4orf37 0.54 7.41 0.41 1.65e-12 Colonoscopy-negative controls vs population controls; CESC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg18337363 chr3:52569053 NT5DC2 0.3 5.57 0.32 6.38e-8 Intelligence (multi-trait analysis); CESC trans rs561341 1.000 rs508192 chr17:30315147 C/T cg20587970 chr11:113659929 NA 1.36 16.18 0.7 2.03e-41 Hip circumference adjusted for BMI; CESC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.59 6.94 0.39 2.92e-11 Height; CESC cis rs4268898 0.896 rs2702042 chr2:24546542 C/T cg06627628 chr2:24431161 ITSN2 -0.69 -8.44 -0.46 2.11e-15 Asthma; CESC cis rs9583531 0.527 rs2391866 chr13:111363294 A/T cg24331049 chr13:111365604 ING1 0.75 10.98 0.56 2.28e-23 Coronary artery disease; CESC cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1950626 0.716 rs34572720 chr14:101447150 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.82 11.17 0.57 5.57e-24 Pelvic organ prolapse (moderate/severe); CESC cis rs344364 0.511 rs12599337 chr16:1946751 A/G cg03013636 chr16:1946785 NA -0.41 -5.63 -0.33 4.71e-8 Glomerular filtration rate in chronic kidney disease; CESC cis rs6456156 0.716 rs6905876 chr6:167521562 C/T cg07741184 chr6:167504864 NA 0.36 5.99 0.35 6.67e-9 Primary biliary cholangitis; CESC cis rs4664304 0.754 rs17829052 chr2:160821067 G/A cg03641300 chr2:160917029 PLA2R1 -0.41 -5.59 -0.33 5.5e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs3126085 0.935 rs4326625 chr1:152223996 C/T cg09127314 chr1:152161683 NA 0.47 5.09 0.3 6.96e-7 Atopic dermatitis; CESC cis rs2629540 0.924 rs2629541 chr10:126425866 G/A cg08799069 chr10:126477246 METTL10 0.69 8.41 0.46 2.52e-15 Cocaine dependence; CESC cis rs7809950 1.000 rs4727681 chr7:107096144 T/C cg23024343 chr7:107201750 COG5 -0.41 -5.78 -0.33 2.12e-8 Coronary artery disease; CESC cis rs12477438 0.501 rs13000731 chr2:99795231 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 12.45 0.61 2.6e-28 Chronic sinus infection; CESC cis rs4268898 0.560 rs2384007 chr2:24514841 A/G cg20701182 chr2:24300061 SF3B14 0.54 5.71 0.33 2.99e-8 Asthma; CESC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg17911788 chr17:44343683 NA -0.43 -6.77 -0.38 8.27e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2354432 0.556 rs57388899 chr1:146773422 T/C cg25205988 chr1:146714368 CHD1L -0.96 -10.48 -0.54 1.03e-21 Mitochondrial DNA levels; CESC cis rs9733 0.596 rs12089989 chr1:150715782 G/A cg04414720 chr1:150670196 GOLPH3L 0.54 7.57 0.42 6.18e-13 Tonsillectomy; CESC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg02951883 chr7:2050386 MAD1L1 -0.49 -6.5 -0.37 3.96e-10 Bipolar disorder and schizophrenia; CESC cis rs7582720 1.000 rs114123510 chr2:203831212 T/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00815117 chr17:27085788 C17orf63 -0.61 -6.72 -0.38 1.1e-10 Gut microbiome composition (summer); CESC cis rs2063714 0.658 rs12196864 chr6:157212862 C/T cg23222435 chr6:157204239 ARID1B -0.42 -5.43 -0.32 1.27e-7 Sitting height ratio; CESC cis rs8033133 0.957 rs7162559 chr15:25352341 C/T cg14481604 chr15:25334117 SNORD116-22 0.36 5.21 0.3 3.76e-7 Blood osmolality (transformed sodium); CESC cis rs3733585 0.624 rs58130873 chr4:9972081 T/C cg11266682 chr4:10021025 SLC2A9 -0.58 -10.87 -0.56 5.3e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs12477438 0.765 rs4851183 chr2:99629149 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs11792861 0.926 rs75472294 chr9:111804239 G/A cg05043794 chr9:111880884 C9orf5 -0.4 -6.65 -0.38 1.7e-10 Menarche (age at onset); CESC cis rs10979 1.000 rs9496671 chr6:143884742 G/A cg25407410 chr6:143891975 LOC285740 -0.63 -9.54 -0.51 9.83e-19 Hypospadias; CESC cis rs701145 0.556 rs355764 chr3:154013480 A/T cg16511985 chr3:153974050 SGEF 0.42 5.94 0.34 8.7e-9 Coronary artery disease; CESC cis rs910316 1.000 rs4903289 chr14:75623988 C/T cg08847533 chr14:75593920 NEK9 -1.0 -20.02 -0.78 6.05e-55 Height; CESC cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg23711669 chr6:146136114 FBXO30 -1.0 -15.53 -0.69 4.13e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs6540556 0.608 rs2205985 chr1:209912100 A/G cg05527609 chr1:210001259 C1orf107 -0.43 -5.07 -0.3 7.55e-7 Red blood cell count; CESC cis rs965469 0.948 rs2236094 chr20:3260368 C/G cg25506879 chr20:3388711 C20orf194 0.56 6.12 0.35 3.35e-9 IFN-related cytopenia; CESC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg13114125 chr14:105738426 BRF1 0.58 7.46 0.42 1.26e-12 Mean platelet volume;Platelet distribution width; CESC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg09323728 chr8:95962352 TP53INP1 -0.4 -8.71 -0.47 3.25e-16 Type 2 diabetes; CESC cis rs116095464 0.558 rs10080225 chr5:232175 A/G cg22857025 chr5:266934 NA -1.29 -18.24 -0.75 1.01e-48 Breast cancer; CESC cis rs853679 1.000 rs9986596 chr6:28219661 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.78 7.97 0.44 4.83e-14 Depression; CESC cis rs7914558 1.000 rs10509757 chr10:104752960 C/T cg15744005 chr10:104629667 AS3MT -0.34 -5.59 -0.32 5.64e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs1728785 1.000 rs11075680 chr16:68565700 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs7647973 0.769 rs6446204 chr3:49034879 T/C cg07636037 chr3:49044803 WDR6 0.87 11.14 0.56 6.91e-24 Menarche (age at onset); CESC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg25072359 chr17:41440525 NA 0.43 5.76 0.33 2.39e-8 Menopause (age at onset); CESC cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg20503657 chr10:835505 NA 0.76 7.59 0.42 5.51e-13 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08708735 chr7:1609515 KIAA1908;PSMG3 0.65 7.72 0.43 2.33e-13 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6964587 0.934 rs7798973 chr7:91588360 G/A cg17063962 chr7:91808500 NA 0.58 7.94 0.44 5.67e-14 Breast cancer; CESC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg26119090 chr2:26468346 HADHA;HADHB 1.05 11.85 0.59 2.86e-26 Gut microbiome composition (summer); CESC cis rs7584330 0.740 rs12471291 chr2:238441751 T/G cg06639874 chr2:238417703 MLPH -0.37 -5.23 -0.31 3.41e-7 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13063040 chr8:145669623 NFKBIL2 -0.47 -6.54 -0.37 3.23e-10 Fibrinogen levels; CESC cis rs7940866 0.838 rs10750455 chr11:130800330 C/T cg12179176 chr11:130786555 SNX19 0.67 10.2 0.53 8.24e-21 Schizophrenia; CESC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Lung function (FEV1); CESC trans rs1728785 1.000 rs1728765 chr16:68589433 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.81 0.43 1.32e-13 Ulcerative colitis; CESC cis rs2180341 0.782 rs6912552 chr6:127722946 C/G cg24812749 chr6:127587940 RNF146 -0.82 -11.93 -0.59 1.46e-26 Breast cancer; CESC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 6.77 0.38 8.17e-11 Bipolar disorder; CESC trans rs17808461 1.000 rs7214574 chr17:31374848 C/A cg01914314 chr5:157117640 NA -0.51 -6.22 -0.36 1.98e-9 Obesity-related traits; CESC cis rs2425143 1.000 rs7267759 chr20:34257284 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.16 0.3 4.75e-7 Blood protein levels; CESC cis rs854765 0.693 rs8079418 chr17:17924060 C/T cg16928487 chr17:17741425 SREBF1 -0.52 -9.13 -0.49 1.83e-17 Total body bone mineral density; CESC cis rs11148252 0.532 rs9536262 chr13:53303074 A/C cg00495681 chr13:53174319 NA -0.62 -8.67 -0.47 4.54e-16 Lewy body disease; CESC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg07211511 chr3:129823064 LOC729375 -0.59 -7.19 -0.4 6.46e-12 Blood pressure (smoking interaction); CESC cis rs4662945 0.525 rs28625431 chr2:130303333 A/G cg05903289 chr2:130345205 NA -0.44 -7.02 -0.4 1.91e-11 Response to cytidine analogues (gemcitabine); CESC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg11644478 chr21:40555479 PSMG1 -0.81 -12.01 -0.59 8.15e-27 Cognitive function; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg27022615 chr11:70049105 FADD -0.47 -6.09 -0.35 4.05e-9 Height; CESC cis rs4974559 0.947 rs6847321 chr4:1347374 C/T cg02475777 chr4:1388615 CRIPAK 0.5 5.09 0.3 6.83e-7 Systolic blood pressure; CESC cis rs6963495 0.818 rs73192126 chr7:105175415 T/C cg19920283 chr7:105172520 RINT1 0.68 6.44 0.37 5.53e-10 Bipolar disorder (body mass index interaction); CESC cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg13647721 chr17:30228624 UTP6 0.7 7.41 0.41 1.68e-12 Hip circumference adjusted for BMI; CESC cis rs3820928 0.904 rs10188570 chr2:227792540 G/A cg05526886 chr2:227700861 RHBDD1 -0.48 -5.83 -0.34 1.62e-8 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23348582 chr14:82000250 SEL1L 0.53 6.09 0.35 4.03e-9 Gut microbiome composition (summer); CESC cis rs2645694 0.532 rs2645706 chr4:77829606 A/C cg18351406 chr4:77819688 ANKRD56 0.49 5.92 0.34 9.69e-9 Emphysema distribution in smoking; CESC cis rs7103648 0.897 rs3758675 chr11:47400602 G/A cg20307385 chr11:47447363 PSMC3 0.95 14.26 0.66 1.26e-34 Diastolic blood pressure;Systolic blood pressure; CESC cis rs965469 0.779 rs6037544 chr20:3290570 A/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.4 -0.31 1.48e-7 IFN-related cytopenia; CESC trans rs16893526 0.858 rs1931644 chr6:82579675 T/C cg07163173 chr2:67624373 ETAA1 0.79 6.0 0.35 6.4e-9 Coronary heart disease; CESC cis rs9486715 0.867 rs9384585 chr6:96875664 C/T cg18709589 chr6:96969512 KIAA0776 0.45 6.46 0.37 5.05e-10 Headache; CESC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg16680214 chr1:154839983 KCNN3 -0.53 -8.23 -0.45 8.61e-15 Prostate cancer; CESC cis rs6912958 0.559 rs376633 chr6:88042785 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.45 8.01 0.44 3.73e-14 Monocyte percentage of white cells; CESC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg12463550 chr7:65579703 CRCP -0.53 -6.77 -0.38 8.05e-11 Aortic root size; CESC trans rs5756813 0.688 rs8140207 chr22:38130459 G/T cg19894588 chr14:64061835 NA -0.65 -7.57 -0.42 6.16e-13 Optic cup area;Vertical cup-disc ratio; CESC cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs35306767 0.953 rs12762973 chr10:960761 C/G cg25019033 chr10:957182 NA -0.66 -7.71 -0.43 2.59e-13 Eosinophil percentage of granulocytes; CESC cis rs7605827 0.930 rs11691392 chr2:15498781 C/T cg19274914 chr2:15703543 NA 0.31 5.64 0.33 4.41e-8 Educational attainment (years of education); CESC cis rs12042938 0.507 rs1655299 chr1:231732161 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.44 -0.46 2.13e-15 Neuranatomic and neurocognitive phenotypes; CESC cis rs9916302 0.706 rs1874226 chr17:37729031 C/T cg07936489 chr17:37558343 FBXL20 0.97 11.36 0.57 1.21e-24 Glomerular filtration rate (creatinine); CESC cis rs66573146 0.572 rs66819208 chr4:6946128 A/G cg26116260 chr4:7069785 GRPEL1 -0.8 -5.23 -0.31 3.39e-7 Granulocyte percentage of myeloid white cells; CESC cis rs7208859 0.673 rs73271887 chr17:29154935 T/C cg19761014 chr17:28927070 LRRC37B2 0.74 6.03 0.35 5.43e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg19592336 chr6:28129416 ZNF389 0.58 7.71 0.43 2.54e-13 Depression; CESC cis rs546131 0.928 rs550313 chr11:34830919 C/T cg06937548 chr11:34938143 PDHX;APIP 0.53 6.55 0.37 3.03e-10 Lung disease severity in cystic fibrosis; CESC cis rs7916697 0.947 rs7916410 chr10:69995667 T/C cg06988349 chr10:69991859 ATOH7 -0.37 -5.96 -0.34 8.14e-9 Optic disc area; CESC cis rs2486288 0.656 rs11854365 chr15:45558083 G/A cg21132104 chr15:45694354 SPATA5L1 -0.55 -6.71 -0.38 1.16e-10 Glomerular filtration rate; CESC cis rs476633 0.691 rs28409265 chr15:41539404 G/A cg12386646 chr15:41787261 ITPKA 0.35 5.19 0.3 4.24e-7 Glomerular filtration rate (creatinine); CESC cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg24110177 chr3:50126178 RBM5 0.54 7.52 0.42 8.46e-13 Intelligence (multi-trait analysis); CESC cis rs12618769 0.625 rs72819970 chr2:99034554 C/G cg10123293 chr2:99228465 UNC50 0.38 5.06 0.3 7.83e-7 Bipolar disorder; CESC cis rs1506636 0.962 rs1019220 chr7:123365122 G/A cg03229431 chr7:123269106 ASB15 -0.52 -6.91 -0.39 3.58e-11 Plateletcrit;Platelet count; CESC trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.41 0.46 2.54e-15 Intelligence (multi-trait analysis); CESC cis rs12497850 0.931 rs6446253 chr3:48911443 C/T cg07636037 chr3:49044803 WDR6 1.02 19.13 0.76 7.5e-52 Parkinson's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07017209 chr1:220263177 BPNT1 -0.48 -6.3 -0.36 1.2e-9 Ulcerative colitis; CESC cis rs3806843 0.801 rs801170 chr5:140115343 C/T cg26395211 chr5:140044315 WDR55 0.45 5.99 0.35 6.94e-9 Depressive symptoms (multi-trait analysis); CESC cis rs1035144 0.506 rs7150858 chr14:81280425 T/C cg06600135 chr14:81408086 NA -0.47 -6.42 -0.37 6.37e-10 Male sexual orientation; CESC cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg26874164 chr19:58962979 ZNF324B 0.54 7.41 0.41 1.7e-12 Uric acid clearance; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24128593 chr6:151712759 ZBTB2 -0.51 -6.52 -0.37 3.52e-10 Ulcerative colitis; CESC cis rs67311347 0.544 rs9877105 chr3:40333366 T/C cg09455208 chr3:40491958 NA 0.35 6.27 0.36 1.43e-9 Renal cell carcinoma; CESC cis rs7555523 0.830 rs6426936 chr1:165684707 C/T cg24409356 chr1:165738333 TMCO1 -0.84 -7.71 -0.43 2.57e-13 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg04944784 chr2:26401820 FAM59B -0.66 -7.53 -0.42 8.04e-13 Gut microbiome composition (summer); CESC cis rs2267137 0.835 rs2267133 chr22:29765382 A/T cg07256473 chr22:29710276 RASL10A 0.41 6.38 0.36 8.08e-10 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs8016982 0.520 rs7160599 chr14:81713739 C/T cg26740341 chr6:22874184 NA 0.44 6.07 0.35 4.53e-9 Schizophrenia; CESC cis rs2243480 1.000 rs160639 chr7:65579987 C/G cg13147721 chr7:65941812 NA -0.96 -9.13 -0.49 1.79e-17 Diabetic kidney disease; CESC cis rs2559856 1.000 rs2695288 chr12:102088112 T/C cg15068132 chr12:102092402 CHPT1 -0.42 -5.59 -0.33 5.5e-8 Blood protein levels; CESC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg04518342 chr5:131593106 PDLIM4 0.38 5.33 0.31 2.1e-7 Blood metabolite levels; CESC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg07507251 chr3:52567010 NT5DC2 0.42 7.2 0.4 6.23e-12 Bipolar disorder; CESC cis rs7186908 0.793 rs7191623 chr16:72212044 G/A cg01557791 chr16:72042693 DHODH -0.7 -7.32 -0.41 2.88e-12 Liver enzyme levels (alkaline phosphatase); CESC cis rs1044826 0.642 rs2118981 chr3:139178853 A/G cg00490450 chr3:139108681 COPB2 0.4 5.03 0.3 9.23e-7 Obesity-related traits; CESC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg04944784 chr2:26401820 FAM59B 0.92 9.76 0.51 2.02e-19 Gut microbiome composition (summer); CESC cis rs854765 0.718 rs7224815 chr17:17845800 A/T cg16928487 chr17:17741425 SREBF1 -0.57 -9.45 -0.5 1.91e-18 Total body bone mineral density; CESC cis rs7917772 0.503 rs11191330 chr10:104306160 G/T ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.38 0.31 1.64e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7264396 0.790 rs761826 chr20:34194243 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.45 -0.46 2.02e-15 Total cholesterol levels; CESC cis rs12477438 0.765 rs62154638 chr2:99639584 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs7520050 0.931 rs1707333 chr1:46547035 C/G cg03146154 chr1:46216737 IPP -0.44 -5.69 -0.33 3.34e-8 Red blood cell count;Reticulocyte count; CESC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg08470875 chr2:26401718 FAM59B 0.75 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26071963 chr14:88945568 PTPN21 0.51 6.93 0.39 3.24e-11 Fibrinogen levels; CESC cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg23711669 chr6:146136114 FBXO30 1.03 15.92 0.7 1.7e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg19912559 chr1:40204330 PPIE 0.42 6.48 0.37 4.44e-10 Blood protein levels; CESC cis rs6681460 0.966 rs10889642 chr1:67143334 T/G cg02459107 chr1:67143332 SGIP1 0.36 5.15 0.3 4.99e-7 Presence of antiphospholipid antibodies; CESC cis rs116095464 0.558 rs62344345 chr5:257420 C/T cg22496380 chr5:211416 CCDC127 -0.73 -8.39 -0.46 2.99e-15 Breast cancer; CESC cis rs734999 0.505 rs4648659 chr1:2560903 T/G cg20673091 chr1:2541236 MMEL1 -0.48 -8.01 -0.44 3.71e-14 Ulcerative colitis; CESC cis rs10751667 1.000 rs10751667 chr11:941941 A/T cg01483505 chr11:975446 AP2A2 0.39 5.24 0.31 3.27e-7 Alzheimer's disease (late onset); CESC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg24578937 chr1:2090814 PRKCZ 0.38 6.65 0.38 1.71e-10 Height; CESC cis rs61776719 0.520 rs11485595 chr1:38411350 C/T cg12658694 chr1:38397304 INPP5B 0.64 9.15 0.49 1.53e-17 Coronary artery disease; CESC cis rs13720 0.722 rs191490 chr20:57576180 A/G cg23907860 chr20:57583709 CTSZ -0.49 -6.01 -0.35 6.26e-9 Platelet distribution width; CESC cis rs6998277 1.000 rs6998277 chr8:103639941 T/C cg10187029 chr8:103597600 NA 0.47 5.56 0.32 6.59e-8 Migraine; CESC cis rs7208859 0.673 rs11652370 chr17:29097223 G/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.21 0.3 3.78e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7937682 0.883 rs484834 chr11:111465761 G/C cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC cis rs870825 0.860 rs72703519 chr4:185602707 G/A cg04058563 chr4:185651563 MLF1IP 0.54 5.24 0.31 3.27e-7 Blood protein levels; CESC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg20243544 chr17:37824526 PNMT 0.48 6.03 0.35 5.4e-9 Glomerular filtration rate (creatinine); CESC cis rs11098499 0.566 rs7664440 chr4:120578540 A/G cg24375607 chr4:120327624 NA 0.44 5.31 0.31 2.3e-7 Corneal astigmatism; CESC cis rs11711311 1.000 rs9826808 chr3:113455644 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.27 0.53 4.81e-21 IgG glycosylation; CESC cis rs11785400 0.731 rs4736363 chr8:143742112 C/A cg10596483 chr8:143751796 JRK 0.41 5.28 0.31 2.64e-7 Schizophrenia; CESC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg11764359 chr7:65958608 NA -0.94 -15.5 -0.69 5.29e-39 Aortic root size; CESC trans rs116095464 0.558 rs9654453 chr5:299621 T/C cg00938859 chr5:1591904 SDHAP3 0.71 6.56 0.37 2.86e-10 Breast cancer; CESC cis rs6570726 0.791 rs398408 chr6:145801020 G/A cg05347473 chr6:146136440 FBXO30 0.57 7.38 0.41 2.04e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs8062405 0.755 rs4788074 chr16:28593597 A/G cg07382826 chr16:28625726 SULT1A1 -0.4 -6.69 -0.38 1.3e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg12648201 chr2:27665141 KRTCAP3 -0.33 -5.84 -0.34 1.52e-8 Total body bone mineral density; CESC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg02592271 chr2:27665507 KRTCAP3 -0.32 -6.54 -0.37 3.19e-10 Total body bone mineral density; CESC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg06420487 chr17:61919686 SMARCD2 0.45 5.36 0.31 1.82e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14001871 chr13:113488290 ATP11A -0.5 -6.07 -0.35 4.51e-9 Gut microbiome composition (summer); CESC cis rs12497850 1.000 rs4858828 chr3:48724811 C/T cg07636037 chr3:49044803 WDR6 0.9 15.21 0.68 5.33e-38 Parkinson's disease; CESC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 6.0 0.35 6.28e-9 Electroencephalogram traits; CESC cis rs9300255 0.770 rs28683528 chr12:123845351 C/T cg19016782 chr12:123741754 C12orf65 0.44 6.2 0.36 2.22e-9 Neutrophil percentage of white cells; CESC cis rs7020830 0.898 rs7857936 chr9:37078491 T/C cg14294708 chr9:37120828 ZCCHC7 1.24 23.78 0.83 1.08e-67 Schizophrenia; CESC cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg03433033 chr1:76189801 ACADM -0.58 -6.33 -0.36 1.04e-9 Blood metabolite levels;Acylcarnitine levels; CESC trans rs9929218 0.817 rs8055912 chr16:68802068 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.45 -0.46 1.98e-15 Colorectal cancer; CESC cis rs826838 1.000 rs10880826 chr12:38672787 G/C cg26384229 chr12:38710491 ALG10B 0.81 14.2 0.66 2.04e-34 Heart rate; CESC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg18904891 chr8:8559673 CLDN23 0.7 8.19 0.45 1.14e-14 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08222081 chr3:150264537 SERP1;EIF2A 0.55 6.06 0.35 4.78e-9 Gut microbiome composition (summer); CESC cis rs1355223 0.525 rs12280958 chr11:34872799 G/A cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.64 -0.38 1.81e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs36051895 0.522 rs12341844 chr9:5177872 C/T cg02405213 chr9:5042618 JAK2 -0.5 -6.5 -0.37 3.92e-10 Pediatric autoimmune diseases; CESC cis rs12586317 0.620 rs79832710 chr14:35547434 G/T cg16230307 chr14:35515116 FAM177A1 0.96 10.2 0.53 7.97e-21 Psoriasis; CESC cis rs3767633 0.858 rs7532448 chr1:161862745 C/T cg09175582 chr1:161736000 ATF6 0.85 6.91 0.39 3.53e-11 IgG glycosylation; CESC trans rs9354308 0.903 rs1938064 chr6:66559172 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.54 -6.52 -0.37 3.47e-10 Metabolite levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08052428 chr9:135996421 RALGDS -0.45 -6.62 -0.38 1.97e-10 Gambling; CESC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.15 -0.3 5.11e-7 Total body bone mineral density; CESC cis rs9815354 1.000 rs6599179 chr3:41855284 C/T cg03022575 chr3:42003672 ULK4 0.45 5.21 0.31 3.73e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs2354432 0.943 rs6660219 chr1:146691404 A/T cg25205988 chr1:146714368 CHD1L 1.1 11.55 0.58 3.01e-25 Mitochondrial DNA levels; CESC cis rs10200159 1.000 rs6739788 chr2:55862355 A/T cg13617705 chr2:55845095 SMEK2 0.68 5.33 0.31 2.07e-7 Vitiligo; CESC cis rs7223966 0.921 rs67018565 chr17:61928055 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.36 0.36 8.58e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2243480 0.522 rs12698511 chr7:65474919 G/T cg18252515 chr7:66147081 NA -1.21 -9.19 -0.49 1.22e-17 Diabetic kidney disease; CESC cis rs3820928 0.874 rs4675137 chr2:227883910 G/C cg05526886 chr2:227700861 RHBDD1 -0.43 -5.48 -0.32 9.75e-8 Pulmonary function; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg10392504 chr7:5464594 TNRC18 0.48 6.0 0.35 6.47e-9 Tetralogy of Fallot; CESC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg13147721 chr7:65941812 NA 0.37 5.04 0.3 8.48e-7 Aortic root size; CESC cis rs7927771 1.000 rs7105282 chr11:47805614 C/A cg05585544 chr11:47624801 NA -0.5 -7.79 -0.43 1.48e-13 Subjective well-being; CESC cis rs7552167 0.789 rs6424162 chr1:24512576 T/C cg01960748 chr1:24522592 NA -0.4 -5.15 -0.3 5.17e-7 Psoriasis vulgaris; CESC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg26354017 chr1:205819088 PM20D1 -0.44 -5.74 -0.33 2.56e-8 Parkinson's disease; CESC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg09165964 chr15:75287851 SCAMP5 0.45 6.13 0.35 3.2e-9 Breast cancer; CESC cis rs8020095 0.528 rs4636843 chr14:67730600 G/A cg19548862 chr14:67692701 FAM71D -0.45 -5.43 -0.32 1.28e-7 Depression (quantitative trait); CESC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg07507251 chr3:52567010 NT5DC2 0.42 7.32 0.41 2.95e-12 Bipolar disorder; CESC cis rs8058578 0.945 rs8058961 chr16:30809063 G/A cg00531865 chr16:30841666 NA -0.4 -5.11 -0.3 6.28e-7 Multiple myeloma; CESC cis rs6831352 0.959 rs4699710 chr4:100051819 C/T cg13256891 chr4:100009986 ADH5 0.72 8.45 0.46 1.94e-15 Alcohol dependence; CESC cis rs10979 0.964 rs9496683 chr6:143898845 G/A cg25407410 chr6:143891975 LOC285740 -0.6 -9.01 -0.48 4.13e-17 Hypospadias; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24170415 chr4:185747632 ACSL1 -0.45 -6.39 -0.37 7.34e-10 Gambling; CESC cis rs2115536 0.935 rs11854390 chr15:80224817 C/T cg00225070 chr15:80189496 MTHFS 0.4 5.35 0.31 1.88e-7 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs67366981 0.720 rs4396457 chr14:77685379 G/A cg22824376 chr14:77648248 TMEM63C 0.78 7.51 0.42 9.21e-13 Obsessive-compulsive symptoms; CESC cis rs11190604 1.000 rs2489048 chr10:102348497 G/T cg07080220 chr10:102295463 HIF1AN 0.59 5.38 0.31 1.67e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs796364 0.951 rs281776 chr2:200834282 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.9 9.11 0.49 2.07e-17 Schizophrenia; CESC cis rs6835098 0.924 rs1991727 chr4:174163169 A/G cg08422745 chr4:174089978 GALNT7 -0.69 -9.95 -0.52 5.02e-20 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs2191566 0.922 rs7245749 chr19:44513932 G/A cg20607764 chr19:44506953 ZNF230 -0.58 -7.6 -0.42 5.17e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs2011503 1.000 rs6511029 chr19:19471419 G/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.5 -5.08 -0.3 7.2e-7 Bipolar disorder; CESC cis rs1545257 0.537 rs12988283 chr2:24642086 G/C cg06627628 chr2:24431161 ITSN2 -0.48 -5.88 -0.34 1.25e-8 Sjögren's syndrome; CESC cis rs12042107 0.967 rs12089815 chr1:91189933 G/A cg13456504 chr1:91191583 NA 0.36 6.49 0.37 4.31e-10 Educational attainment; CESC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg05564831 chr3:52568323 NT5DC2 0.44 6.68 0.38 1.37e-10 Bipolar disorder; CESC cis rs7188861 0.768 rs1646026 chr16:11382695 C/T cg01510278 chr16:11456238 NA 0.33 5.1 0.3 6.53e-7 HDL cholesterol; CESC cis rs3858526 0.676 rs10838772 chr11:5895754 T/C cg13902645 chr11:5959945 NA -0.56 -6.71 -0.38 1.21e-10 DNA methylation (variation); CESC cis rs1986734 0.560 rs4859683 chr4:77419073 C/T cg20311846 chr4:77356250 SHROOM3 -0.26 -5.28 -0.31 2.63e-7 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC cis rs1023500 0.596 rs133352 chr22:42434022 C/A cg04733989 chr22:42467013 NAGA 0.8 11.87 0.59 2.45e-26 Schizophrenia; CESC cis rs13256369 0.802 rs2280560 chr8:8560602 C/T cg18904891 chr8:8559673 CLDN23 0.71 7.96 0.44 4.92e-14 Obesity-related traits; CESC cis rs9913156 0.670 rs4470203 chr17:4567798 G/A cg00122941 chr17:4613640 ARRB2 -0.6 -7.37 -0.41 2.24e-12 Lymphocyte counts; CESC cis rs6460942 0.915 rs7803056 chr7:12306913 A/C cg06484146 chr7:12443880 VWDE -0.47 -6.41 -0.37 6.52e-10 Coronary artery disease; CESC cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.52 8.84 0.48 1.35e-16 Monocyte percentage of white cells; CESC cis rs2295499 0.773 rs2298961 chr4:2644961 T/A cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.23 -0.31 3.4e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg20887711 chr4:1340912 KIAA1530 0.85 11.44 0.58 6.72e-25 Longevity; CESC cis rs763121 0.819 rs138700 chr22:39129999 A/G cg06022373 chr22:39101656 GTPBP1 0.94 16.52 0.71 1.23e-42 Menopause (age at onset); CESC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg00106254 chr7:1943704 MAD1L1 -0.46 -5.66 -0.33 4.01e-8 Bipolar disorder and schizophrenia; CESC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg01097406 chr16:89675127 NA -0.33 -5.04 -0.3 8.63e-7 Vitiligo; CESC cis rs959260 0.925 rs9747801 chr17:73396572 C/T cg20590849 chr17:73267439 MIF4GD -0.54 -6.24 -0.36 1.75e-9 Systemic lupus erythematosus; CESC cis rs3806843 0.735 rs2563314 chr5:140047289 A/G cg16179182 chr5:140090404 VTRNA1-1 0.39 5.11 0.3 6.21e-7 Depressive symptoms (multi-trait analysis); CESC cis rs4566357 0.557 rs6707158 chr2:227911269 A/G cg05526886 chr2:227700861 RHBDD1 -0.45 -5.99 -0.35 6.98e-9 Coronary artery disease; CESC cis rs12220238 1.000 rs11000936 chr10:75992383 A/T cg19889307 chr10:75911429 ADK;AP3M1 0.65 6.47 0.37 4.65e-10 Soluble interleukin-2 receptor subunit alpha; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03798359 chr20:2443604 SNRPB;SNORD119 -0.37 -6.47 -0.37 4.81e-10 Gambling; CESC cis rs7089973 0.604 rs8181444 chr10:116588981 C/T cg23260525 chr10:116636907 FAM160B1 0.4 7.19 0.4 6.76e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9926296 0.682 rs258328 chr16:89730314 C/T cg04287289 chr16:89883240 FANCA -0.44 -5.61 -0.33 5e-8 Vitiligo; CESC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg22920501 chr2:26401640 FAM59B 0.72 8.12 0.45 1.74e-14 Gut microbiome composition (summer); CESC cis rs9291683 0.588 rs3756237 chr4:10013378 G/A cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.16e-46 Bone mineral density; CESC cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg13628971 chr7:2884303 GNA12 0.4 5.36 0.31 1.85e-7 Height; CESC cis rs8067354 0.540 rs72840315 chr17:58018142 G/C cg13753209 chr17:57696993 CLTC 0.51 5.63 0.33 4.57e-8 Hemoglobin concentration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11312980 chr14:64931897 AKAP5 -0.43 -6.08 -0.35 4.27e-9 Gut microbiota (bacterial taxa); CESC cis rs9905704 0.918 rs11655808 chr17:56854517 T/C cg12560992 chr17:57184187 TRIM37 0.6 6.94 0.39 2.93e-11 Testicular germ cell tumor; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06225581 chr5:140080094 ZMAT2 0.46 6.09 0.35 3.9e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg12963246 chr6:28129442 ZNF389 0.57 7.77 0.43 1.75e-13 Depression; CESC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.69 8.44 0.46 2.12e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13253111 0.624 rs1979330 chr8:28096051 T/A cg26534493 chr8:28060551 NA 0.48 7.41 0.41 1.73e-12 Childhood body mass index; CESC cis rs8072100 0.544 rs7214993 chr17:45386797 C/G cg08085267 chr17:45401833 C17orf57 -0.42 -5.23 -0.31 3.44e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.28 0.41 3.71e-12 Prudent dietary pattern; CESC cis rs2576037 0.796 rs2576039 chr18:44582148 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.61 -8.66 -0.47 4.73e-16 Personality dimensions; CESC cis rs870825 0.860 rs28799091 chr4:185598594 G/A cg04058563 chr4:185651563 MLF1IP 0.6 6.11 0.35 3.53e-9 Blood protein levels; CESC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg25072359 chr17:41440525 NA 0.52 7.92 0.44 6.72e-14 Menopause (age at onset); CESC cis rs113835537 0.529 rs10896125 chr11:66288733 G/C cg22134325 chr11:66188745 NPAS4 0.35 5.59 0.32 5.52e-8 Airway imaging phenotypes; CESC cis rs9549367 0.789 rs12584981 chr13:113881185 T/C cg18105134 chr13:113819100 PROZ -0.65 -8.04 -0.44 2.97e-14 Platelet distribution width; CESC cis rs7267979 1.000 rs2500424 chr20:25391969 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -15.68 -0.69 1.2e-39 Liver enzyme levels (alkaline phosphatase); CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg03188948 chr7:1209495 NA 0.53 7.14 0.4 8.8e-12 Longevity;Endometriosis; CESC cis rs9815354 0.812 rs73073337 chr3:41837497 T/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7539624 0.898 rs2896828 chr1:223898685 T/C cg10100437 chr1:223903862 CAPN2 -0.41 -6.16 -0.35 2.68e-9 Schizophrenia; CESC cis rs4969178 0.832 rs4969185 chr17:76398157 G/C cg05887092 chr17:76393375 PGS1 0.58 9.21 0.49 1.01e-17 HDL cholesterol levels; CESC cis rs6867032 1.000 rs6867032 chr5:2015103 G/T cg26168224 chr5:2018326 NA -0.97 -19.64 -0.77 1.28e-53 Gut microbiome composition (winter); CESC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg17971929 chr21:40555470 PSMG1 1.06 16.39 0.71 3.75e-42 Cognitive function; CESC trans rs7246760 0.867 rs7259075 chr19:9778776 G/A cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs61931739 0.500 rs11053271 chr12:34545407 C/A cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs11098499 0.909 rs28581362 chr4:120283548 T/A cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC trans rs629535 0.862 rs655028 chr8:70049047 T/C cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs7224314 1.000 rs7219229 chr17:65380171 C/T cg01507342 chr17:65387096 PITPNC1 -0.48 -5.68 -0.33 3.45e-8 Diisocyanate-induced asthma; CESC cis rs1018836 0.923 rs2023626 chr8:91619264 G/T cg16814680 chr8:91681699 NA 0.74 10.56 0.54 5.67e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4919694 0.901 rs12251035 chr10:104671459 A/C cg04362960 chr10:104952993 NT5C2 0.78 6.58 0.37 2.5e-10 Arsenic metabolism; CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg18591801 chr3:52553433 STAB1 -0.3 -5.89 -0.34 1.19e-8 Electroencephalogram traits; CESC cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg20891558 chr2:74357851 NA 0.81 11.91 0.59 1.82e-26 Gestational age at birth (maternal effect); CESC cis rs116095464 0.558 rs1812843 chr5:267658 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.86e-15 Breast cancer; CESC cis rs1775715 0.737 rs11008695 chr10:32216887 T/G cg18675610 chr10:32216311 ARHGAP12 0.37 5.63 0.33 4.69e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs12476592 0.571 rs7606045 chr2:63826528 T/G cg17519650 chr2:63277830 OTX1 -0.44 -5.23 -0.31 3.39e-7 Childhood ear infection; CESC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg23758822 chr17:41437982 NA 1.01 15.72 0.69 8.46e-40 Menopause (age at onset); CESC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.08e-9 Aortic root size; CESC cis rs2737618 0.722 rs1986405 chr1:200095935 C/G cg21825944 chr1:200113062 NR5A2 -0.41 -6.13 -0.35 3.19e-9 Uric acid levels; CESC cis rs1707322 1.000 rs10890350 chr1:46262378 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.68 0.33 3.51e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg06958567 chr18:52495541 RAB27B -0.51 -7.04 -0.4 1.7e-11 Height; CESC cis rs7927771 0.524 rs10838774 chr11:47856114 A/G cg20307385 chr11:47447363 PSMC3 0.65 9.24 0.49 8.43e-18 Subjective well-being; CESC cis rs7264396 0.733 rs6060515 chr20:34211779 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.52 0.42 8.28e-13 Total cholesterol levels; CESC trans rs11098499 0.754 rs28652763 chr4:120242312 C/T cg25214090 chr10:38739885 LOC399744 0.61 8.47 0.46 1.73e-15 Corneal astigmatism; CESC trans rs9929218 0.906 rs10852450 chr16:68749529 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -10.57 -0.54 5.06e-22 Colorectal cancer; CESC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg11494091 chr17:61959527 GH2 0.73 12.39 0.61 4.19e-28 Prudent dietary pattern; CESC cis rs6669072 0.590 rs10922922 chr1:91237055 G/A cg08895590 chr1:91227319 NA 0.34 5.8 0.34 1.85e-8 Cognitive function; CESC cis rs7537660 1.000 rs7522811 chr1:248005213 C/G cg12080717 chr1:248004886 OR11L1 0.41 5.27 0.31 2.76e-7 Platelet distribution width; CESC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg04267008 chr7:1944627 MAD1L1 -0.57 -6.89 -0.39 4.08e-11 Bipolar disorder and schizophrenia; CESC cis rs7683537 0.725 rs28837443 chr4:185641497 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg18180107 chr4:99064573 C4orf37 0.41 5.24 0.31 3.24e-7 Colonoscopy-negative controls vs population controls; CESC cis rs67366981 0.841 rs55903932 chr14:77706389 T/C cg22824376 chr14:77648248 TMEM63C 0.72 5.76 0.33 2.35e-8 Obsessive-compulsive symptoms; CESC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg12641515 chr19:46296257 DMWD 0.73 9.86 0.52 9.65e-20 Coronary artery disease; CESC cis rs4423214 1.000 rs3750997 chr11:71158841 A/C cg24826892 chr11:71159390 DHCR7 0.46 5.48 0.32 9.79e-8 Vitamin D levels; CESC cis rs12912251 1.000 rs2132157 chr15:38992547 A/G cg01338139 chr15:38987640 C15orf53 -0.49 -5.59 -0.32 5.54e-8 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs2119480 0.762 rs401084 chr13:111310086 C/G cg16216153 chr13:111290848 CARKD -0.35 -5.16 -0.3 4.88e-7 Diastolic blood pressure; CESC cis rs4132509 0.744 rs10927068 chr1:243923452 C/T cg21452805 chr1:244014465 NA 0.57 6.8 0.39 7.09e-11 RR interval (heart rate); CESC cis rs1904096 0.506 rs7697827 chr4:95184748 G/A cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.28 -0.5 6.25e-18 Type 2 diabetes; CESC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg11494091 chr17:61959527 GH2 0.73 12.55 0.61 1.13e-28 Prudent dietary pattern; CESC trans rs7672847 0.547 rs6818590 chr4:170478577 A/C cg19308436 chr1:237949471 RYR2 0.65 6.9 0.39 3.89e-11 Subjective well-being; CESC cis rs78456975 1.000 rs13392535 chr2:1542634 G/T cg01028140 chr2:1542097 TPO -0.61 -5.79 -0.34 2e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs3820068 0.655 rs72645823 chr1:15887442 C/T cg18192808 chr1:15853278 DNAJC16 0.43 5.17 0.3 4.6e-7 Systolic blood pressure; CESC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg02951883 chr7:2050386 MAD1L1 -0.42 -5.37 -0.31 1.75e-7 Bipolar disorder and schizophrenia; CESC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg11247378 chr22:39784982 NA -0.62 -7.76 -0.43 1.85e-13 IgG glycosylation; CESC trans rs629535 0.814 rs654452 chr8:70074344 C/G cg21567404 chr3:27674614 NA 0.88 10.34 0.54 2.74e-21 Dupuytren's disease; CESC cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg06713675 chr4:122721982 EXOSC9 -0.5 -6.96 -0.39 2.65e-11 Type 2 diabetes; CESC cis rs6968419 0.714 rs17138472 chr7:115892738 A/G cg02561103 chr7:115862891 TES -0.39 -5.05 -0.3 8.05e-7 Intraocular pressure; CESC cis rs4253772 0.614 rs11090859 chr22:46687460 T/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.59 6.21 0.36 2.02e-9 LDL cholesterol;Cholesterol, total; CESC cis rs662064 0.755 rs6667629 chr1:10524467 T/C cg20482658 chr1:10539492 PEX14 0.29 5.03 0.3 8.89e-7 Asthma; CESC cis rs11190604 1.000 rs2295780 chr10:102305965 A/G cg07080220 chr10:102295463 HIF1AN 0.62 5.58 0.32 5.83e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg03806693 chr22:41940476 POLR3H 1.2 13.99 0.65 1.16e-33 Vitiligo; CESC trans rs62103177 0.608 rs4799115 chr18:77736365 A/T cg05926928 chr17:57297772 GDPD1 -0.68 -6.29 -0.36 1.34e-9 Opioid sensitivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08450091 chr3:82857215 NA 0.5 7.17 0.4 7.33e-12 Fibrinogen levels; CESC cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg04478727 chr12:58166393 METTL1;FAM119B -0.69 -8.69 -0.47 3.91e-16 Multiple sclerosis; CESC cis rs56235845 0.796 rs13153019 chr5:176782218 T/C cg16006841 chr5:176797999 RGS14 0.62 6.35 0.36 9.51e-10 Hemoglobin concentration;Hematocrit; CESC cis rs7586673 0.866 rs747003 chr2:161916409 C/T cg21518248 chr2:162101506 NA -0.47 -6.46 -0.37 4.99e-10 Intelligence (multi-trait analysis); CESC cis rs735860 0.737 rs2115564 chr6:53173482 C/A cg10236188 chr6:53219634 NA -0.36 -5.26 -0.31 2.98e-7 Glaucoma; CESC cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg03433033 chr1:76189801 ACADM 0.7 9.43 0.5 2.18e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg23422044 chr7:1970798 MAD1L1 0.51 5.35 0.31 1.86e-7 Bipolar disorder; CESC cis rs123509 0.687 rs73075301 chr3:42832650 C/T cg12982090 chr3:42733453 KBTBD5 -0.66 -7.52 -0.42 8.26e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs116095464 0.558 rs9654452 chr5:299561 C/T cg22857025 chr5:266934 NA -1.28 -17.85 -0.74 2.52e-47 Breast cancer; CESC cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs3808502 0.525 rs9650661 chr8:11427133 G/T cg15556689 chr8:8085844 FLJ10661 -0.58 -6.84 -0.39 5.45e-11 Neuroticism; CESC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg13628971 chr7:2884303 GNA12 0.64 8.55 0.46 1.02e-15 Height; CESC cis rs425277 0.959 rs77665022 chr1:2065958 C/T cg16545954 chr1:2118288 C1orf86 0.33 5.59 0.32 5.77e-8 Height; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg10434075 chr17:55038112 COIL 0.49 6.29 0.36 1.33e-9 Breast cancer;Type 2 diabetes; CESC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg12463550 chr7:65579703 CRCP 0.5 6.3 0.36 1.21e-9 Aortic root size; CESC cis rs782590 0.774 rs782632 chr2:55898290 C/G cg18811423 chr2:55921094 PNPT1 0.78 12.9 0.62 7e-30 Metabolic syndrome; CESC cis rs9549367 0.713 rs576463 chr13:113846614 C/T cg18105134 chr13:113819100 PROZ 0.53 6.78 0.38 7.56e-11 Platelet distribution width; CESC cis rs9611565 0.592 rs80477 chr22:42001183 C/T cg03806693 chr22:41940476 POLR3H 0.84 9.77 0.51 1.84e-19 Vitiligo; CESC cis rs1538970 1.000 rs9326141 chr1:45828943 A/G cg03146154 chr1:46216737 IPP -0.44 -5.2 -0.3 4e-7 Platelet count; CESC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg27057461 chr7:158136379 PTPRN2 -0.33 -5.17 -0.3 4.6e-7 Calcium levels; CESC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg24642844 chr7:1081250 C7orf50 -0.76 -9.26 -0.49 7.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9487051 0.597 rs351732 chr6:109507691 G/T cg01475377 chr6:109611718 NA -0.39 -5.17 -0.3 4.54e-7 Reticulocyte fraction of red cells; CESC cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg24308560 chr3:49941425 MST1R 0.62 9.16 0.49 1.45e-17 Intelligence (multi-trait analysis); CESC cis rs7605827 0.866 rs2032692 chr2:15616847 A/G cg19274914 chr2:15703543 NA 0.33 5.96 0.34 8.22e-9 Educational attainment (years of education); CESC cis rs2481665 0.608 rs2476194 chr1:62594593 C/T cg18591186 chr1:62594603 INADL -0.79 -12.14 -0.6 2.94e-27 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11997175 0.603 rs4739381 chr8:33806892 C/A ch.8.33884649F chr8:33765107 NA 0.44 5.25 0.31 3.19e-7 Body mass index; CESC cis rs5753618 0.504 rs7284622 chr22:31907985 G/A cg13145458 chr22:31556086 RNF185 -0.48 -5.69 -0.33 3.33e-8 Colorectal cancer; CESC cis rs3857067 1.000 rs115969971 chr4:95023550 T/C cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs8180040 0.654 rs6791062 chr3:47174343 T/A cg27129171 chr3:47204927 SETD2 0.66 9.85 0.52 1.07e-19 Colorectal cancer; CESC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg08392591 chr16:89556376 ANKRD11 0.56 7.65 0.43 3.78e-13 Multiple myeloma (IgH translocation); CESC trans rs3808502 0.585 rs4549730 chr8:11239078 T/G cg15556689 chr8:8085844 FLJ10661 -0.48 -6.09 -0.35 3.85e-9 Neuroticism; CESC cis rs3820928 0.874 rs2228557 chr2:227872182 G/A cg05526886 chr2:227700861 RHBDD1 -0.44 -5.49 -0.32 9.38e-8 Pulmonary function; CESC cis rs7072216 0.763 rs6584198 chr10:100169906 G/C cg26618903 chr10:100175079 PYROXD2 -0.37 -5.76 -0.33 2.33e-8 Metabolite levels; CESC cis rs4835473 0.864 rs17750354 chr4:144658505 T/A cg25736465 chr4:144833511 NA -0.33 -5.25 -0.31 3.1e-7 Immature fraction of reticulocytes; CESC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg17971929 chr21:40555470 PSMG1 -0.87 -12.56 -0.61 1.04e-28 Cognitive function; CESC cis rs796364 0.806 rs1605900 chr2:200870197 C/G cg23649088 chr2:200775458 C2orf69 0.6 5.37 0.31 1.74e-7 Schizophrenia; CESC cis rs7927771 0.524 rs10458915 chr11:47864392 T/A cg20307385 chr11:47447363 PSMC3 0.63 8.77 0.47 2.17e-16 Subjective well-being; CESC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg24829409 chr8:58192753 C8orf71 -0.75 -10.01 -0.52 3.22e-20 Developmental language disorder (linguistic errors); CESC cis rs2243480 1.000 rs34637256 chr7:65360131 G/A cg18252515 chr7:66147081 NA -1.06 -9.89 -0.52 7.86e-20 Diabetic kidney disease; CESC cis rs7267979 0.744 rs6050463 chr20:25208990 G/A cg08601574 chr20:25228251 PYGB 0.38 5.48 0.32 9.93e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7202877 0.706 rs247423 chr16:75456631 C/A cg04384234 chr16:75411784 CFDP1 0.48 5.68 0.33 3.58e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs2637266 0.745 rs2579733 chr10:78441896 C/T cg18941641 chr10:78392320 NA -0.39 -7.08 -0.4 1.31e-11 Pulmonary function; CESC cis rs1983170 1.000 rs597288 chr1:91999296 C/T cg25838465 chr1:92012736 NA 0.45 5.42 0.32 1.35e-7 Eosinophil percentage of white cells; CESC cis rs3105593 0.966 rs2063010 chr15:50941131 A/G cg08437265 chr15:50716283 USP8 0.41 5.34 0.31 1.96e-7 QT interval; CESC cis rs8036030 0.604 rs11852686 chr15:74715205 A/G cg14664628 chr15:75095509 CSK -0.45 -5.47 -0.32 1.04e-7 Airflow obstruction; CESC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg04025307 chr7:1156635 C7orf50 0.59 10.37 0.54 2.19e-21 Longevity;Endometriosis; CESC cis rs7296418 0.922 rs1727293 chr12:123648032 C/T cg05973401 chr12:123451056 ABCB9 0.52 6.71 0.38 1.19e-10 Platelet count; CESC cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13570982 chr14:55596240 LGALS3 0.6 6.7 0.38 1.25e-10 Gut microbiome composition (summer); CESC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg22800045 chr5:56110881 MAP3K1 -0.59 -7.59 -0.42 5.38e-13 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26929161 chr20:50701266 ZFP64 -0.5 -6.27 -0.36 1.43e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09274451 chr16:89353600 ANKRD11 -0.57 -6.26 -0.36 1.56e-9 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs7539800 chr1:46262129 C/G cg05343316 chr1:45956843 TESK2 -0.49 -5.92 -0.34 9.91e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11625487 0.957 rs10145540 chr14:77957354 C/T cg20065768 chr16:29796685 NA 0.48 6.6 0.38 2.24e-10 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs11098499 1.000 rs28374891 chr4:120183550 G/A cg24375607 chr4:120327624 NA 0.43 5.16 0.3 4.79e-7 Corneal astigmatism; CESC cis rs939574 0.818 rs6744146 chr2:220070597 T/A cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.58 -5.55 -0.32 7.07e-8 Platelet distribution width; CESC cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg17971929 chr21:40555470 PSMG1 0.78 7.7 0.43 2.8e-13 Cognitive function; CESC cis rs7223966 1.000 rs9901507 chr17:61765524 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.58 -0.32 5.85e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6761276 0.649 rs3811055 chr2:113831182 A/T cg12858261 chr2:113808755 IL1F8 0.46 5.68 0.33 3.63e-8 Protein quantitative trait loci; CESC cis rs13385 0.769 rs13359060 chr5:139605202 C/T cg26211634 chr5:139558579 C5orf32 0.47 5.16 0.3 4.78e-7 Atrial fibrillation; CESC cis rs6460942 0.908 rs79175014 chr7:12245378 T/G cg06484146 chr7:12443880 VWDE -0.66 -6.67 -0.38 1.44e-10 Coronary artery disease; CESC cis rs1152591 0.792 rs1152595 chr14:64674981 T/C cg23250157 chr14:64679961 SYNE2 0.5 6.8 0.39 7.12e-11 Atrial fibrillation; CESC trans rs2018683 0.677 rs55718000 chr7:28975625 T/C cg19402173 chr7:128379420 CALU -0.48 -6.38 -0.36 7.9e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs16989760 0.661 rs67935422 chr22:32020413 G/A cg01338084 chr22:32026380 PISD 1.19 8.21 0.45 9.91e-15 Age-related hearing impairment; CESC cis rs936229 0.861 rs11634474 chr15:75116184 C/G cg14664628 chr15:75095509 CSK -0.98 -16.2 -0.71 1.69e-41 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs9815354 0.812 rs73077365 chr3:41851559 T/C cg03022575 chr3:42003672 ULK4 0.66 6.0 0.35 6.55e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg05368731 chr17:41323189 NBR1 0.77 10.46 0.54 1.12e-21 Menopause (age at onset); CESC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.05e-8 Lung cancer; CESC cis rs11252926 0.501 rs2050971 chr10:525530 T/G cg03684893 chr10:554711 DIP2C 0.46 6.99 0.39 2.2e-11 Psychosis in Alzheimer's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08885106 chr8:144550663 ZC3H3 -0.45 -6.21 -0.36 2.02e-9 Gut microbiota (bacterial taxa); CESC cis rs1448094 0.817 rs73176252 chr12:86347649 T/A cg02569458 chr12:86230093 RASSF9 0.39 5.68 0.33 3.61e-8 Major depressive disorder; CESC cis rs736408 0.677 rs678 chr3:52820981 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 5.63 0.33 4.47e-8 Bipolar disorder; CESC cis rs7429990 1.000 rs1665982 chr3:47905079 A/G cg11946769 chr3:48343235 NME6 -0.52 -5.62 -0.33 4.91e-8 Educational attainment (years of education); CESC cis rs9640161 0.789 rs10952250 chr7:150025966 T/C cg21361702 chr7:150065534 REPIN1 0.46 5.44 0.32 1.18e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs787274 0.718 rs10739379 chr9:115640976 C/G cg13803584 chr9:115635662 SNX30 -0.7 -5.45 -0.32 1.16e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7605827 0.930 rs763356 chr2:15518816 G/T cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg00071950 chr4:10020882 SLC2A9 0.81 14.25 0.66 1.38e-34 Bone mineral density; CESC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.58 7.36 0.41 2.35e-12 Alzheimer's disease; CESC cis rs62432291 0.681 rs450538 chr6:159659523 A/G cg14500486 chr6:159655392 FNDC1 -0.62 -6.34 -0.36 9.83e-10 Joint mobility (Beighton score); CESC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs3008870 0.959 rs2985816 chr1:67387750 G/T cg08660285 chr1:67390436 MIER1;WDR78 1.06 14.98 0.68 3.54e-37 Lymphocyte percentage of white cells; CESC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.78 0.65 6.16e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9913156 0.793 rs9916135 chr17:4568115 A/C cg00122941 chr17:4613640 ARRB2 -0.82 -9.66 -0.51 4.06e-19 Lymphocyte counts; CESC cis rs2249694 0.960 rs4335490 chr10:135402350 T/C cg20169779 chr10:135381914 SYCE1 -0.4 -5.86 -0.34 1.4e-8 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08074427 chr7:43798806 BLVRA 0.65 7.33 0.41 2.76e-12 Gut microbiome composition (summer); CESC cis rs2456568 0.867 rs1395384 chr11:93663250 C/T cg26875233 chr11:93583750 C11orf90 0.3 5.25 0.31 3.2e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs1005277 0.505 rs10827835 chr10:38150709 G/A cg25427524 chr10:38739819 LOC399744 0.68 9.93 0.52 5.76e-20 Extrinsic epigenetic age acceleration; CESC cis rs1670533 1.000 rs62879260 chr4:1050850 T/C cg27284194 chr4:1044797 NA 0.44 5.49 0.32 9.49e-8 Recombination rate (females); CESC cis rs8077577 0.747 rs3817992 chr17:18194011 C/A cg16794390 chr17:18148240 FLII 0.41 6.45 0.37 5.26e-10 Obesity-related traits; CESC cis rs72781680 0.800 rs6718635 chr2:24066183 A/C cg08917208 chr2:24149416 ATAD2B 1.13 10.31 0.54 3.47e-21 Lymphocyte counts; CESC cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.49 5.13 0.3 5.66e-7 Cerebrospinal P-tau181p levels; CESC cis rs829883 0.724 rs3168521 chr12:98908547 C/T cg25150519 chr12:98850993 NA -0.64 -7.9 -0.44 7.53e-14 Colorectal adenoma (advanced); CESC cis rs9616064 0.506 rs2542038 chr22:47059282 C/T cg25730555 chr22:47059586 GRAMD4 0.47 7.13 0.4 9.5e-12 Urate levels in obese individuals; CESC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg18404041 chr3:52824283 ITIH1 -0.41 -6.75 -0.38 9.55e-11 Bipolar disorder; CESC trans rs875971 0.660 rs1860470 chr7:66103694 G/C cg26939375 chr7:64535504 NA -0.59 -7.96 -0.44 5.08e-14 Aortic root size; CESC cis rs28374715 0.578 rs10518717 chr15:41623368 C/G cg18705301 chr15:41695430 NDUFAF1 -1.06 -15.79 -0.7 4.85e-40 Ulcerative colitis; CESC cis rs9611565 0.512 rs1534932 chr22:42150146 C/T cg06634786 chr22:41940651 POLR3H 0.71 7.05 0.4 1.59e-11 Vitiligo; CESC trans rs11098499 0.863 rs3775843 chr4:120427844 T/C cg25214090 chr10:38739885 LOC399744 0.71 9.77 0.51 1.88e-19 Corneal astigmatism; CESC cis rs921968 0.643 rs659185 chr2:219335935 C/T cg02176678 chr2:219576539 TTLL4 0.38 6.75 0.38 9.19e-11 Mean corpuscular hemoglobin concentration; CESC cis rs2243480 1.000 rs402418 chr7:65509469 G/A cg18252515 chr7:66147081 NA -1.28 -12.48 -0.61 2.04e-28 Diabetic kidney disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08810106 chr16:18936940 SMG1 0.5 6.31 0.36 1.16e-9 Gut microbiota (bacterial taxa); CESC cis rs4450798 0.744 rs9653971 chr3:13749727 T/C cg05589046 chr3:13742034 LOC285375 0.38 5.72 0.33 2.82e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg07677032 chr17:61819896 STRADA 0.42 5.33 0.31 2.08e-7 Height; CESC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg11644478 chr21:40555479 PSMG1 1.02 16.14 0.7 2.71e-41 Cognitive function; CESC cis rs10870270 0.956 rs4880405 chr10:133787021 G/A cg26149184 chr10:133730230 NA 0.39 5.32 0.31 2.24e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs10911232 0.507 rs4652767 chr1:183002483 G/C ch.1.3577855R chr1:183094577 LAMC1 0.85 13.33 0.63 2.22e-31 Hypertriglyceridemia; CESC cis rs79839061 0.656 rs28662837 chr4:879776 G/A cg07828340 chr4:882639 GAK 1.07 8.55 0.47 9.76e-16 Intelligence (multi-trait analysis); CESC cis rs2288073 0.801 rs2384008 chr2:24373150 A/G cg06627628 chr2:24431161 ITSN2 -0.74 -9.43 -0.5 2.09e-18 Venous thromboembolism (SNP x SNP interaction); CESC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg18252515 chr7:66147081 NA -0.43 -5.62 -0.33 4.86e-8 Aortic root size; CESC cis rs637571 0.544 rs55704213 chr11:65730002 C/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 10.26 0.53 5.13e-21 Eosinophil percentage of white cells; CESC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.43 -0.32 1.28e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs4315565 0.764 rs4594480 chr2:69287998 G/A cg12800200 chr2:69260302 ANTXR1 -0.42 -6.08 -0.35 4.23e-9 Height; CESC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs7116495 1.000 rs4944232 chr11:71642258 A/G cg10381502 chr11:71823885 C11orf51 0.67 5.65 0.33 4.19e-8 Severe influenza A (H1N1) infection; CESC cis rs8053891 0.756 rs9928413 chr16:72001110 C/T cg04254540 chr16:71951199 KIAA0174 -0.42 -5.49 -0.32 9.18e-8 Coronary artery disease; CESC cis rs116095464 0.558 rs13354585 chr5:242263 G/C cg10591111 chr5:226296 SDHA -0.52 -6.43 -0.37 6.06e-10 Breast cancer; CESC cis rs2481665 0.817 rs2476198 chr1:62611071 C/A cg18591186 chr1:62594603 INADL -0.42 -5.18 -0.3 4.3e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.37 -0.54 2.25e-21 Alzheimer's disease; CESC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2439831 0.850 rs16950562 chr15:44036364 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.69 6.68 0.38 1.39e-10 Lung cancer in ever smokers; CESC cis rs2742234 0.518 rs2505514 chr10:43633248 A/G cg15436174 chr10:43711423 RASGEF1A -0.5 -5.66 -0.33 3.84e-8 Hirschsprung disease; CESC cis rs1008375 0.966 rs6449313 chr4:17588320 A/G cg02297831 chr4:17616191 MED28 0.5 5.95 0.34 8.67e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg21573476 chr21:45109991 RRP1B -0.45 -6.29 -0.36 1.28e-9 Mean corpuscular volume; CESC cis rs921968 0.565 rs12694439 chr2:219590871 A/G cg02176678 chr2:219576539 TTLL4 -0.43 -7.59 -0.42 5.51e-13 Mean corpuscular hemoglobin concentration; CESC cis rs1950626 0.699 rs12880424 chr14:101459660 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.83 10.01 0.52 3.28e-20 Pelvic organ prolapse (moderate/severe); CESC cis rs4144743 1.000 rs67615769 chr17:45325478 A/G cg18085866 chr17:45331354 ITGB3 -0.61 -6.56 -0.37 2.75e-10 Body mass index; CESC cis rs7584330 0.518 rs74003104 chr2:238446823 C/T cg14458575 chr2:238380390 NA 0.67 6.29 0.36 1.3e-9 Prostate cancer; CESC cis rs2276314 1.000 rs62101367 chr18:33550884 C/T cg05985134 chr18:33552581 C18orf21 0.67 7.84 0.43 1.07e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs6701037 0.566 rs729675 chr1:175136946 T/C cg00321850 chr1:175162397 KIAA0040 0.44 6.24 0.36 1.75e-9 Alcohol dependence; CESC trans rs7839040 0.698 rs7841753 chr8:82929864 G/A cg14472086 chr9:107730925 NA -0.48 -6.3 -0.36 1.26e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs4835473 0.897 rs17693780 chr4:144658716 G/T cg25736465 chr4:144833511 NA -0.34 -5.3 -0.31 2.46e-7 Immature fraction of reticulocytes; CESC cis rs72781680 0.848 rs56218741 chr2:23977377 A/C cg08917208 chr2:24149416 ATAD2B 0.96 8.7 0.47 3.55e-16 Lymphocyte counts; CESC cis rs3781663 0.553 rs875108 chr11:70004695 G/A cg06393558 chr11:69982916 ANO1 -0.34 -5.86 -0.34 1.39e-8 Survival in rectal cancer; CESC cis rs2425143 1.000 rs8116836 chr20:34453362 T/A cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.51 0.32 8.37e-8 Blood protein levels; CESC cis rs644799 0.511 rs10831420 chr11:95478209 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.46 5.84 0.34 1.55e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg12310025 chr6:25882481 NA -0.6 -9.04 -0.49 3.29e-17 Intelligence (multi-trait analysis); CESC cis rs1348850 0.645 rs11889272 chr2:178432378 C/T cg22681709 chr2:178499509 PDE11A -0.55 -6.66 -0.38 1.53e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs75804782 0.641 rs2340870 chr2:239356026 C/T cg18131467 chr2:239335373 ASB1 -0.68 -5.91 -0.34 1.05e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 12.57 0.61 1e-28 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02113521 chr15:22892956 CYFIP1 0.54 6.11 0.35 3.5e-9 Gut microbiome composition (summer); CESC cis rs2243480 0.808 rs12698508 chr7:65411958 A/T cg12463550 chr7:65579703 CRCP 0.7 5.45 0.32 1.16e-7 Diabetic kidney disease; CESC trans rs7615952 0.515 rs4267608 chr3:125680500 C/T cg07211511 chr3:129823064 LOC729375 -0.64 -6.36 -0.36 8.64e-10 Blood pressure (smoking interaction); CESC cis rs6867032 0.874 rs4975786 chr5:2004724 T/C cg26168224 chr5:2018326 NA -0.83 -13.39 -0.64 1.4e-31 Gut microbiome composition (winter); CESC trans rs877282 0.898 rs12356744 chr10:757477 G/C cg22713356 chr15:30763199 NA 1.05 9.16 0.49 1.45e-17 Uric acid levels; CESC cis rs6570726 0.875 rs1883407 chr6:145823432 T/C cg23711669 chr6:146136114 FBXO30 0.76 11.32 0.57 1.68e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.73 10.81 0.55 8.21e-23 Hip circumference adjusted for BMI; CESC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg01988459 chr11:68622903 NA -0.45 -6.02 -0.35 5.69e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg04455712 chr21:45112962 RRP1B 0.49 7.5 0.42 9.42e-13 Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04068686 chr19:5719947 TMEM146;LONP1 -0.42 -6.08 -0.35 4.13e-9 Gambling; CESC cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg17366294 chr4:99064904 C4orf37 0.62 8.78 0.47 2.05e-16 Colonoscopy-negative controls vs population controls; CESC cis rs8067545 0.586 rs2703819 chr17:20121401 A/G cg13482628 chr17:19912719 NA -0.41 -5.58 -0.32 5.98e-8 Schizophrenia; CESC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg24829409 chr8:58192753 C8orf71 -0.75 -10.01 -0.52 3.22e-20 Developmental language disorder (linguistic errors); CESC cis rs3733585 0.699 rs6449179 chr4:9969117 G/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.57 -0.32 6.13e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3780486 0.846 rs3780490 chr9:33129839 A/G cg13443165 chr9:33130375 B4GALT1 0.45 6.46 0.37 5.07e-10 IgG glycosylation; CESC trans rs3942852 0.712 rs10742828 chr11:48104555 A/G cg03929089 chr4:120376271 NA -0.6 -6.89 -0.39 4.03e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg05283184 chr6:79620031 NA -0.44 -6.74 -0.38 9.96e-11 Intelligence (multi-trait analysis); CESC cis rs10463316 0.817 rs12653378 chr5:150802366 A/G cg03212797 chr5:150827313 SLC36A1 -0.48 -6.2 -0.36 2.1e-9 Metabolite levels (Pyroglutamine); CESC cis rs258892 0.895 rs6882092 chr5:72086928 G/A cg21869765 chr5:72125136 TNPO1 -0.42 -5.42 -0.32 1.36e-7 Small cell lung carcinoma; CESC cis rs11997175 0.646 rs61693382 chr8:33697255 A/C ch.8.33884649F chr8:33765107 NA 0.56 7.43 0.41 1.54e-12 Body mass index; CESC cis rs854765 0.647 rs2056842 chr17:18009028 C/T cg16928487 chr17:17741425 SREBF1 -0.54 -8.79 -0.48 1.88e-16 Total body bone mineral density; CESC cis rs1912483 0.545 rs35161461 chr17:45401757 A/G cg08085267 chr17:45401833 C17orf57 -0.64 -7.73 -0.43 2.18e-13 Coronary artery disease; CESC cis rs4692589 1.000 rs12643956 chr4:170932819 A/C cg19918862 chr4:170955249 NA 0.36 5.63 0.33 4.66e-8 Anxiety disorder; CESC cis rs7084402 0.967 rs1649046 chr10:60326109 T/C cg07615347 chr10:60278583 BICC1 0.61 9.55 0.51 8.96e-19 Refractive error; CESC cis rs763121 0.889 rs4820335 chr22:38935927 C/G cg06544989 chr22:39130855 UNC84B -0.45 -7.93 -0.44 6.12e-14 Menopause (age at onset); CESC cis rs8020095 0.571 rs7158228 chr14:67562723 T/C cg19548862 chr14:67692701 FAM71D -0.47 -5.63 -0.33 4.6e-8 Depression (quantitative trait); CESC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg12463550 chr7:65579703 CRCP 0.59 7.45 0.42 1.29e-12 Aortic root size; CESC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg26354017 chr1:205819088 PM20D1 0.5 7.2 0.4 6.35e-12 Menarche (age at onset); CESC cis rs7640424 0.826 rs7635063 chr3:107818777 C/T cg09227934 chr3:107805635 CD47 -0.53 -6.97 -0.39 2.48e-11 Body mass index; CESC cis rs6582630 0.519 rs8186881 chr12:38310285 A/G cg26384229 chr12:38710491 ALG10B 0.71 10.65 0.55 2.8e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs55788414 1.000 rs28395434 chr16:81182222 G/A cg06400318 chr16:81190750 PKD1L2 -0.6 -7.01 -0.4 1.96e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs67311347 0.910 rs7617361 chr3:40373259 G/T cg24209194 chr3:40518798 ZNF619 0.46 6.06 0.35 4.64e-9 Renal cell carcinoma; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00735591 chr19:10828665 DNM2;MIR638 -0.47 -6.1 -0.35 3.7e-9 Asthma; CESC cis rs864537 0.646 rs1723018 chr1:167433420 A/G cg22356347 chr1:167427500 CD247 -0.36 -7.69 -0.43 2.94e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg24543097 chr20:388556 RBCK1 0.44 6.29 0.36 1.27e-9 Thyroid stimulating hormone; CESC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.62 0.38 2.02e-10 Bipolar disorder; CESC cis rs4969178 0.965 rs3817295 chr17:76394526 T/A cg05887092 chr17:76393375 PGS1 0.57 9.02 0.48 3.94e-17 HDL cholesterol levels; CESC cis rs6674176 0.628 rs7556565 chr1:44416090 C/T cg13606994 chr1:44402422 ARTN -0.37 -5.53 -0.32 7.66e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2979489 0.891 rs2915625 chr8:30382651 G/A cg26383811 chr8:30366931 RBPMS -0.81 -9.9 -0.52 7.35e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs950776 0.518 rs8025429 chr15:78836362 G/A cg06917634 chr15:78832804 PSMA4 -0.77 -11.76 -0.59 5.63e-26 Sudden cardiac arrest; CESC cis rs208520 0.526 rs9354370 chr6:66808209 C/T cg07460842 chr6:66804631 NA 1.11 25.48 0.84 3.14e-73 Exhaled nitric oxide output; CESC cis rs7662987 0.517 rs2602882 chr4:100040765 C/T cg13256891 chr4:100009986 ADH5 0.74 7.89 0.44 7.94e-14 Smoking initiation; CESC cis rs45535039 0.922 rs12287028 chr11:119123949 A/T cg16724696 chr11:118992527 HINFP 0.42 5.27 0.31 2.84e-7 Plateletcrit; CESC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.75 10.61 0.55 3.65e-22 Prudent dietary pattern; CESC cis rs9467711 0.675 rs58825580 chr6:26365679 T/G cg14345882 chr6:26364793 BTN3A2 0.57 6.08 0.35 4.24e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2235642 0.928 rs2076435 chr16:1607574 C/T cg03771183 chr16:1608904 IFT140 0.42 6.16 0.35 2.64e-9 Coronary artery disease; CESC cis rs7296418 0.754 rs1619283 chr12:123717362 A/G cg05973401 chr12:123451056 ABCB9 0.49 6.24 0.36 1.71e-9 Platelet count; CESC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg23708337 chr7:1209742 NA 0.55 5.54 0.32 7.28e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2243480 1.000 rs937108 chr7:65428452 G/A cg13147721 chr7:65941812 NA -0.87 -8.59 -0.47 7.56e-16 Diabetic kidney disease; CESC trans rs561341 1.000 rs2470243 chr17:30290955 C/T cg27661571 chr11:113659931 NA -0.87 -8.06 -0.44 2.57e-14 Hip circumference adjusted for BMI; CESC cis rs1670533 0.769 rs6814833 chr4:1057679 A/C cg04106633 chr4:1044584 NA 0.41 5.19 0.3 4.11e-7 Recombination rate (females); CESC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg22823121 chr1:150693482 HORMAD1 0.45 6.25 0.36 1.6e-9 Melanoma; CESC cis rs12950390 0.853 rs11655336 chr17:45858836 A/G cg00777063 chr17:45855553 NA 0.38 5.77 0.33 2.2e-8 IgG glycosylation; CESC trans rs6921919 0.562 rs13198809 chr6:28323702 G/A cg01620082 chr3:125678407 NA -0.82 -6.39 -0.37 7.58e-10 Autism spectrum disorder or schizophrenia; CESC cis rs1395 0.778 rs6749393 chr2:27451000 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.46 6.02 0.35 5.83e-9 Blood metabolite levels; CESC trans rs1814175 0.817 rs7929173 chr11:49944007 T/C cg03929089 chr4:120376271 NA -0.93 -16.26 -0.71 1.03e-41 Height; CESC cis rs2637266 1.000 rs12260379 chr10:78365036 C/T cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs7927771 1.000 rs9909 chr11:47799775 C/G cg18512352 chr11:47633146 NA -0.61 -9.6 -0.51 6.38e-19 Subjective well-being; CESC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg25405998 chr7:65216604 CCT6P1 -0.46 -5.22 -0.31 3.71e-7 Aortic root size; CESC cis rs2976388 0.578 rs13254358 chr8:143823876 G/A cg24634471 chr8:143751801 JRK -0.46 -5.04 -0.3 8.7e-7 Urinary tract infection frequency; CESC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.96 -0.34 7.97e-9 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22346429 chr12:132504721 EP400 -0.58 -6.04 -0.35 5.29e-9 Gut microbiome composition (summer); CESC trans rs5769765 0.862 rs9616380 chr22:50312225 T/C cg09872104 chr7:134855509 C7orf49 -0.55 -6.27 -0.36 1.47e-9 Schizophrenia; CESC cis rs4268898 0.662 rs12052954 chr2:24425620 C/T cg20701182 chr2:24300061 SF3B14 -0.68 -7.35 -0.41 2.43e-12 Asthma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26593722 chr16:87376314 FBXO31 0.47 7.06 0.4 1.46e-11 Fibrinogen levels; CESC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg07677032 chr17:61819896 STRADA 0.47 6.28 0.36 1.4e-9 Prudent dietary pattern; CESC cis rs8017423 0.935 rs3742667 chr14:90767856 T/C cg14092571 chr14:90743983 NA 0.55 8.31 0.45 4.97e-15 Mortality in heart failure; CESC cis rs3780486 0.957 rs10971434 chr9:33168891 C/A cg13443165 chr9:33130375 B4GALT1 0.41 5.41 0.32 1.43e-7 IgG glycosylation; CESC cis rs6732160 0.588 rs28626211 chr2:73378522 G/A cg01422370 chr2:73384389 NA 0.57 9.07 0.49 2.73e-17 Intelligence (multi-trait analysis); CESC cis rs10883723 0.962 rs1056739 chr10:104236542 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.34 0.41 2.67e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.63 0.42 4.19e-13 Prudent dietary pattern; CESC cis rs6546550 0.935 rs10202159 chr2:70062454 G/T cg02498382 chr2:70120550 SNRNP27 -0.39 -6.78 -0.38 7.75e-11 Prevalent atrial fibrillation; CESC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.33 0.31 2.07e-7 Cognitive function; CESC cis rs2295499 0.615 rs57978437 chr4:2711162 C/T cg27239842 chr4:2403781 ZFYVE28 -0.34 -5.82 -0.34 1.69e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs1707322 0.686 rs2991986 chr1:46081282 A/G cg06784218 chr1:46089804 CCDC17 -0.42 -7.33 -0.41 2.79e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg23711669 chr6:146136114 FBXO30 -0.96 -14.29 -0.66 9.59e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.693 rs9907246 chr17:17770965 T/C cg04398451 chr17:18023971 MYO15A 0.63 9.0 0.48 4.49e-17 Total body bone mineral density; CESC cis rs2404618 0.506 rs12156177 chr8:1493684 C/T cg13402656 chr8:1511478 DLGAP2 -0.5 -7.01 -0.4 1.97e-11 Lung cancer; CESC cis rs17376456 0.877 rs10035340 chr5:93490465 C/T cg21475434 chr5:93447410 FAM172A 0.9 7.77 0.43 1.68e-13 Diabetic retinopathy; CESC cis rs113835537 0.529 rs78999944 chr11:66251228 C/G cg22134325 chr11:66188745 NPAS4 0.35 5.48 0.32 1.01e-7 Airway imaging phenotypes; CESC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg24060327 chr5:131705240 SLC22A5 -0.76 -10.69 -0.55 2.14e-22 Breast cancer; CESC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.48 0.42 1.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs709400 0.593 rs12898029 chr14:103877884 T/C cg12935359 chr14:103987150 CKB 0.49 7.32 0.41 2.96e-12 Body mass index; CESC cis rs1215050 0.744 rs966380 chr4:98435389 C/T cg05340658 chr4:99064831 C4orf37 0.44 5.44 0.32 1.21e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs3105593 1.000 rs11634746 chr15:50941496 T/A cg08437265 chr15:50716283 USP8 0.41 5.34 0.31 1.96e-7 QT interval; CESC cis rs6991838 0.584 rs34494846 chr8:66514632 T/C cg13398993 chr8:66546079 ARMC1 -0.45 -5.37 -0.31 1.75e-7 Intelligence (multi-trait analysis); CESC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg25767906 chr1:53392781 SCP2 0.43 6.0 0.35 6.48e-9 Monocyte count; CESC cis rs6973256 0.583 rs2042000 chr7:133322697 T/C cg10665199 chr7:133106180 EXOC4 0.43 5.65 0.33 4.24e-8 Intelligence (multi-trait analysis); CESC cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg21573476 chr21:45109991 RRP1B -0.41 -5.7 -0.33 3.11e-8 Mean corpuscular volume; CESC cis rs34172651 0.583 rs4787649 chr16:24700215 C/T cg00339695 chr16:24857497 SLC5A11 -0.44 -5.94 -0.34 9.13e-9 Intelligence (multi-trait analysis); CESC cis rs35110281 0.712 rs1454648 chr21:45053815 C/T cg21573476 chr21:45109991 RRP1B -0.5 -6.85 -0.39 5.03e-11 Mean corpuscular volume; CESC cis rs2635047 0.615 rs1512238 chr18:44748467 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.04 0.3 8.74e-7 Educational attainment; CESC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg22105103 chr4:187893119 NA 0.46 6.55 0.37 2.98e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2243480 1.000 rs160639 chr7:65579987 C/G cg18252515 chr7:66147081 NA -1.31 -12.88 -0.62 8.56e-30 Diabetic kidney disease; CESC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg18876405 chr7:65276391 NA 0.52 6.87 0.39 4.49e-11 Aortic root size; CESC cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.7 7.22 0.41 5.35e-12 Alzheimer's disease; CESC cis rs2439831 0.867 rs3101443 chr15:43912372 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.68 8.42 0.46 2.36e-15 Lung cancer in ever smokers; CESC cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.63 -9.27 -0.49 6.93e-18 Personality dimensions; CESC cis rs9611565 0.559 rs132768 chr22:42013523 C/A cg17376030 chr22:41985996 PMM1 -0.8 -8.91 -0.48 8.57e-17 Vitiligo; CESC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg05863683 chr7:1912471 MAD1L1 0.37 5.39 0.31 1.56e-7 Bipolar disorder and schizophrenia; CESC cis rs2882667 0.824 rs1560656 chr5:138470789 A/G cg04439458 chr5:138467593 SIL1 0.33 5.23 0.31 3.53e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg11764359 chr7:65958608 NA -0.48 -5.96 -0.34 8.14e-9 Calcium levels; CESC cis rs7116495 0.609 rs10793014 chr11:71698838 A/G cg18441811 chr11:71824068 C11orf51 -0.82 -5.33 -0.31 2.05e-7 Severe influenza A (H1N1) infection; CESC cis rs677665 0.537 rs72641831 chr1:9335173 G/T cg25755851 chr1:9335794 NA 0.96 14.2 0.66 2.07e-34 Eosinophil percentage of white cells; CESC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg03647317 chr4:187891568 NA -0.38 -5.26 -0.31 3.01e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs2777491 0.915 rs28578057 chr15:41621921 G/A cg02330683 chr15:41787940 ITPKA 0.45 6.56 0.37 2.73e-10 Ulcerative colitis; CESC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg20243544 chr17:37824526 PNMT 0.5 6.37 0.36 8.22e-10 Glomerular filtration rate (creatinine); CESC cis rs4969178 0.930 rs4580257 chr17:76403028 T/G cg05887092 chr17:76393375 PGS1 0.59 9.14 0.49 1.74e-17 HDL cholesterol levels; CESC cis rs7208859 0.673 rs9899525 chr17:29120296 T/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.57 0.37 2.69e-10 Bipolar disorder; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg22907277 chr7:1156413 C7orf50 0.46 6.56 0.37 2.81e-10 Longevity;Endometriosis; CESC cis rs8112211 0.911 rs2270095 chr19:38840896 A/G cg14299480 chr19:38876666 GGN -0.45 -6.02 -0.35 5.76e-9 Blood protein levels; CESC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg25036284 chr2:26402008 FAM59B -0.86 -9.4 -0.5 2.73e-18 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00746487 chr13:99293520 NA 0.45 6.36 0.36 8.59e-10 Fibrinogen levels; CESC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs7072216 0.770 rs1061123 chr10:100176997 A/G cg26618903 chr10:100175079 PYROXD2 -0.33 -5.06 -0.3 7.69e-7 Metabolite levels; CESC cis rs3126085 0.735 rs4845744 chr1:152185095 T/A cg26876637 chr1:152193138 HRNR 0.48 5.44 0.32 1.21e-7 Atopic dermatitis; CESC cis rs4835473 0.800 rs1849134 chr4:144879413 A/T cg25736465 chr4:144833511 NA 0.41 6.17 0.35 2.52e-9 Immature fraction of reticulocytes; CESC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 12.02 0.59 7.59e-27 Platelet count; CESC cis rs72781680 1.000 rs7588286 chr2:24071427 A/G cg08917208 chr2:24149416 ATAD2B 0.93 8.48 0.46 1.57e-15 Lymphocyte counts; CESC cis rs13082711 0.522 rs533175 chr3:27361432 A/G cg02860705 chr3:27208620 NA -0.38 -5.24 -0.31 3.32e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs17253792 0.915 rs79894275 chr14:56180285 C/T cg01858014 chr14:56050164 KTN1 -0.94 -7.27 -0.41 4.03e-12 Putamen volume; CESC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg26335602 chr6:28129616 ZNF389 0.54 7.14 0.4 8.92e-12 Depression; CESC cis rs921968 0.541 rs562510 chr2:219443001 A/C cg02176678 chr2:219576539 TTLL4 0.5 8.86 0.48 1.18e-16 Mean corpuscular hemoglobin concentration; CESC cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg06634786 chr22:41940651 POLR3H -0.63 -6.64 -0.38 1.8e-10 Vitiligo; CESC cis rs10899021 0.790 rs7932194 chr11:74327378 C/G cg25880958 chr11:74394337 NA -0.74 -7.91 -0.44 7.23e-14 Response to metformin (IC50); CESC cis rs2439831 0.850 rs28595038 chr15:44044859 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.97 0.44 4.82e-14 Lung cancer in ever smokers; CESC cis rs7592578 0.882 rs7569128 chr2:191446691 C/A cg27211696 chr2:191398769 TMEM194B 0.59 5.3 0.31 2.46e-7 Diastolic blood pressure; CESC cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.64 -7.59 -0.42 5.39e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1538970 0.851 rs61788285 chr1:45919234 A/C cg03146154 chr1:46216737 IPP 0.47 5.44 0.32 1.23e-7 Platelet count; CESC cis rs1879734 0.731 rs12044337 chr1:54160558 C/T cg23596471 chr1:54105337 GLIS1 0.35 5.66 0.33 3.96e-8 Mitral valve prolapse; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17597744 chr8:53627099 RB1CC1 0.6 6.5 0.37 3.92e-10 Gut microbiome composition (summer); CESC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg11965913 chr1:205819406 PM20D1 0.47 7.09 0.4 1.2e-11 Menarche (age at onset); CESC cis rs9473147 0.543 rs9369716 chr6:47552180 A/T cg20196966 chr6:47445060 CD2AP 0.39 5.05 0.3 8.37e-7 Platelet distribution width;Mean platelet volume; CESC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg08888203 chr3:10149979 C3orf24 0.48 6.07 0.35 4.37e-9 Alzheimer's disease; CESC cis rs11190604 1.000 rs1054399 chr10:102312565 C/T cg07080220 chr10:102295463 HIF1AN 0.6 5.72 0.33 2.85e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs3096299 0.933 rs3096297 chr16:89453155 T/G cg08822215 chr16:89438651 ANKRD11 -0.41 -6.14 -0.35 3.07e-9 Multiple myeloma (IgH translocation); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18654971 chr5:54469363 MIR449C;CDC20B 0.52 6.65 0.38 1.71e-10 Gut microbiota (bacterial taxa); CESC cis rs57506017 0.565 rs6460895 chr7:12252540 C/G cg23422036 chr7:12250390 TMEM106B -0.39 -5.24 -0.31 3.21e-7 Neuroticism; CESC cis rs1005277 0.505 rs10827835 chr10:38150709 G/A cg00409905 chr10:38381863 ZNF37A 0.55 7.56 0.42 6.68e-13 Extrinsic epigenetic age acceleration; CESC cis rs12893597 0.715 rs12892786 chr14:76833888 C/T cg20290672 chr14:76816747 NA -0.37 -5.24 -0.31 3.36e-7 Maximal oxygen uptake response; CESC cis rs11249608 0.548 rs7732719 chr5:178463054 A/G cg01312482 chr5:178451176 ZNF879 -0.45 -6.05 -0.35 4.95e-9 Pubertal anthropometrics; CESC cis rs9467711 0.606 rs9393713 chr6:26373678 C/T cg12826209 chr6:26865740 GUSBL1 0.59 5.19 0.3 4.14e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7927771 0.524 rs12286721 chr11:47701528 G/T cg18512352 chr11:47633146 NA -0.36 -5.57 -0.32 6.2e-8 Subjective well-being; CESC trans rs1814175 0.511 rs61905634 chr11:49819736 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -20.13 -0.78 2.46e-55 Height; CESC cis rs1005277 0.522 rs9418276 chr10:37940116 G/T cg25517755 chr10:38738941 LOC399744 -0.42 -5.52 -0.32 8.28e-8 Extrinsic epigenetic age acceleration; CESC cis rs4566357 0.615 rs4675140 chr2:227908665 C/T cg05526886 chr2:227700861 RHBDD1 -0.47 -6.05 -0.35 5.03e-9 Coronary artery disease; CESC trans rs4332037 0.802 rs73048106 chr7:1929019 G/T cg11693508 chr17:37793320 STARD3 0.64 6.13 0.35 3.11e-9 Bipolar disorder; CESC cis rs10847980 1.000 rs10847980 chr12:123387922 G/T cg19120225 chr12:123595024 PITPNM2 -0.67 -5.52 -0.32 8.14e-8 Adiponectin levels; CESC cis rs10876993 0.928 rs1689592 chr12:58057773 C/T cg18357645 chr12:58087776 OS9 0.64 10.45 0.54 1.28e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.34 0.54 2.88e-21 Monocyte percentage of white cells; CESC cis rs863345 0.604 rs10908656 chr1:158461016 A/G cg12129480 chr1:158549410 OR10X1 -0.36 -7.14 -0.4 8.93e-12 Pneumococcal bacteremia; CESC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -11.04 -0.56 1.47e-23 Extrinsic epigenetic age acceleration; CESC cis rs8072100 0.840 rs9895746 chr17:45479099 C/A cg25173405 chr17:45401733 C17orf57 -0.41 -5.47 -0.32 1.04e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg10691866 chr7:65817282 TPST1 0.31 5.34 0.31 2e-7 Aortic root size; CESC cis rs17376456 0.877 rs56373208 chr5:93491276 C/A cg21475434 chr5:93447410 FAM172A 0.9 7.77 0.43 1.68e-13 Diabetic retinopathy; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07934232 chr19:36619082 NA -0.49 -6.15 -0.35 2.81e-9 Ulcerative colitis; CESC cis rs17253792 0.822 rs77197405 chr14:56159662 T/A cg01858014 chr14:56050164 KTN1 -0.97 -7.59 -0.42 5.34e-13 Putamen volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05224827 chr14:50999389 MAP4K5;ATL1 -0.47 -6.67 -0.38 1.48e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4654899 0.802 rs12127519 chr1:21247365 C/T cg05370193 chr1:21551575 ECE1 0.38 5.53 0.32 7.69e-8 Superior frontal gyrus grey matter volume; CESC cis rs17655565 1.000 rs60696802 chr12:52693176 C/T cg08257133 chr12:52711352 KRT83 0.46 5.1 0.3 6.49e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs17401966 0.931 rs11587854 chr1:10447622 G/A cg15208524 chr1:10270712 KIF1B 0.41 5.23 0.31 3.51e-7 Hepatocellular carcinoma; CESC cis rs2882667 0.931 rs7720150 chr5:138334069 C/A cg04439458 chr5:138467593 SIL1 -0.31 -5.35 -0.31 1.9e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg01475377 chr6:109611718 NA -0.5 -8.41 -0.46 2.52e-15 Reticulocyte fraction of red cells; CESC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.57 7.45 0.42 1.32e-12 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08292080 chr16:56398010 AMFR 0.42 6.2 0.36 2.1e-9 Fibrinogen levels; CESC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.56 0.37 2.85e-10 Bipolar disorder; CESC cis rs2429369 0.528 rs2526376 chr17:56427142 A/C cg25039879 chr17:56429692 SUPT4H1 0.43 5.44 0.32 1.18e-7 Cognitive function; CESC cis rs1152591 0.543 rs1152592 chr14:64676098 A/G cg21174375 chr14:64681225 SYNE2 0.63 9.06 0.49 2.95e-17 Atrial fibrillation; CESC cis rs9815354 0.761 rs73083326 chr3:41927150 G/T cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs7589342 0.862 rs6745887 chr2:106468039 G/A cg16077055 chr2:106428750 NCK2 0.54 7.78 0.43 1.66e-13 Addiction; CESC cis rs7615952 0.736 rs9866347 chr3:125669925 C/T cg05084668 chr3:125655381 ALG1L -0.83 -7.89 -0.44 7.91e-14 Blood pressure (smoking interaction); CESC trans rs10489896 0.541 rs12760253 chr1:234577514 G/C cg10395685 chr11:86085715 CCDC81 -0.43 -6.27 -0.36 1.48e-9 Cognitive test performance; CESC cis rs2439831 0.867 rs8039638 chr15:43634405 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.84 12.56 0.61 1.02e-28 Lung cancer in ever smokers; CESC cis rs992157 0.735 rs10932765 chr2:219099484 T/C cg00012203 chr2:219082015 ARPC2 0.84 12.22 0.6 1.49e-27 Colorectal cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg22692790 chr10:70748415 KIAA1279 -0.46 -6.15 -0.35 2.9e-9 Asthma; CESC cis rs9443189 0.763 rs2748952 chr6:76444360 G/A cg01950844 chr6:76311363 SENP6 -0.61 -6.73 -0.38 1.02e-10 Prostate cancer; CESC cis rs7017914 0.967 rs62508819 chr8:71718106 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.39 -0.31 1.54e-7 Bone mineral density; CESC trans rs1814175 0.645 rs4411280 chr11:49962750 A/G cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.49e-38 Height; CESC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg18404041 chr3:52824283 ITIH1 -0.39 -6.63 -0.38 1.85e-10 Bipolar disorder; CESC cis rs35146811 0.961 rs1880949 chr7:99722266 A/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 -0.44 -5.42 -0.32 1.34e-7 Coronary artery disease; CESC cis rs2455799 0.613 rs7614204 chr3:15792748 A/G cg09340198 chr3:15902540 ANKRD28 -0.33 -5.16 -0.3 4.94e-7 Mean platelet volume; CESC cis rs4834770 1.000 rs878374 chr4:120237564 A/G cg09307838 chr4:120376055 NA 0.48 5.92 0.34 1e-8 Blood protein levels; CESC cis rs6084875 0.733 rs6052854 chr20:4742399 A/G cg05143360 chr20:4741328 NA 0.54 7.41 0.41 1.71e-12 Systemic lupus erythematosus; CESC cis rs113835537 0.559 rs74933537 chr11:66274958 A/C cg22134325 chr11:66188745 NPAS4 0.36 5.62 0.33 4.73e-8 Airway imaging phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14487595 chr6:43597054 MAD2L1BP;GTPBP2 0.62 7.58 0.42 5.74e-13 Gut microbiome composition (summer); CESC cis rs2439831 0.850 rs28578398 chr15:44075046 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.97 0.44 4.59e-14 Lung cancer in ever smokers; CESC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg02951883 chr7:2050386 MAD1L1 -0.46 -5.94 -0.34 8.76e-9 Bipolar disorder and schizophrenia; CESC cis rs7267979 1.000 rs6083844 chr20:25386832 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.03 -0.74 5.63e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs6502050 0.805 rs6502057 chr17:80082060 A/G cg23985595 chr17:80112537 CCDC57 0.41 6.4 0.37 7.12e-10 Life satisfaction; CESC trans rs116095464 0.558 rs7356696 chr5:284251 A/G cg00938859 chr5:1591904 SDHAP3 0.65 7.03 0.4 1.73e-11 Breast cancer; CESC cis rs9611565 0.512 rs4820446 chr22:42215684 C/T cg03806693 chr22:41940476 POLR3H -1.17 -13.64 -0.64 1.9e-32 Vitiligo; CESC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg16550651 chr17:40268381 KAT2A -0.36 -5.08 -0.3 7.28e-7 Fibrinogen levels; CESC cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4919087 0.683 rs1687371 chr10:98978183 T/A cg25902810 chr10:99078978 FRAT1 -0.5 -5.7 -0.33 3.19e-8 Monocyte count; CESC cis rs4595586 0.655 rs4142847 chr12:39395128 C/T cg26384229 chr12:38710491 ALG10B 0.43 6.28 0.36 1.35e-9 Morning vs. evening chronotype; CESC cis rs34779708 0.733 rs4444023 chr10:35548354 G/A cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs9318086 0.904 rs9580769 chr13:24439724 T/C cg25267304 chr13:24462978 PCOTH;MIPEP -0.38 -5.27 -0.31 2.88e-7 Myopia (pathological); CESC cis rs13034020 0.522 rs12464096 chr2:61239332 G/C cg18625361 chr2:61244694 PEX13;PUS10 0.66 5.9 0.34 1.13e-8 Hodgkin's lymphoma; CESC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg00684032 chr4:1343700 KIAA1530 0.41 5.72 0.33 2.93e-8 Obesity-related traits; CESC cis rs2011503 1.000 rs8101219 chr19:19643715 G/A cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs1153858 1.000 rs7167900 chr15:45639471 A/G cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs6545883 0.929 rs778140 chr2:61682976 C/T cg15711740 chr2:61764176 XPO1 -0.4 -5.24 -0.31 3.24e-7 Tuberculosis; CESC cis rs15676 0.947 rs2293966 chr9:131591832 G/A cg00228799 chr9:131580591 ENDOG 0.44 5.53 0.32 7.59e-8 Blood metabolite levels; CESC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.44 -5.12 -0.3 6.02e-7 Breast cancer; CESC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg02071572 chr4:1403502 NA 0.34 5.1 0.3 6.55e-7 Longevity; CESC trans rs1814175 0.791 rs1722011 chr11:49899340 G/C cg03929089 chr4:120376271 NA -0.92 -15.84 -0.7 3.16e-40 Height; CESC cis rs9388451 0.874 rs1159974 chr6:126090277 C/T cg05901451 chr6:126070800 HEY2 0.65 9.21 0.49 1.03e-17 Brugada syndrome; CESC cis rs9512730 0.517 rs1967772 chr13:28036062 G/A cg08193333 chr13:27998609 GTF3A 0.42 5.23 0.31 3.39e-7 Schizophrenia; CESC cis rs3126085 0.935 rs56013982 chr1:152176503 C/T cg03465714 chr1:152285911 FLG 0.47 5.25 0.31 3.07e-7 Atopic dermatitis; CESC cis rs2635047 0.542 rs1512235 chr18:44781569 A/G cg24371990 chr18:44770781 NA 0.34 5.47 0.32 1.06e-7 Educational attainment; CESC cis rs11051970 0.559 rs11051992 chr12:32564667 G/T cg24626660 chr12:32551988 NA 0.35 5.03 0.3 9.04e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs208520 0.690 rs851464 chr6:66839802 C/T cg07460842 chr6:66804631 NA -0.99 -13.42 -0.64 1.15e-31 Exhaled nitric oxide output; CESC trans rs17685 0.753 rs10476 chr7:75696420 C/T cg19862616 chr7:65841803 NCRNA00174 -0.82 -12.12 -0.6 3.49e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC trans rs1814175 0.817 rs28679516 chr11:50055998 G/A cg03929089 chr4:120376271 NA -0.94 -15.72 -0.69 8.37e-40 Height; CESC cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg00080972 chr5:178986291 RUFY1 0.36 5.22 0.31 3.64e-7 Lung cancer; CESC cis rs694739 0.734 rs663743 chr11:64107735 G/A cg23796481 chr11:64053134 BAD;GPR137 0.71 8.52 0.46 1.22e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs9948 0.655 rs17119564 chr2:97384728 G/A cg01990225 chr2:97406019 LMAN2L -0.97 -7.25 -0.41 4.52e-12 Erectile dysfunction and prostate cancer treatment; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg12997958 chr17:18161617 FLII -0.48 -6.07 -0.35 4.38e-9 Breast cancer;Type 2 diabetes; CESC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg19592336 chr6:28129416 ZNF389 0.53 6.82 0.39 6.18e-11 Parkinson's disease; CESC cis rs1348850 0.651 rs4893821 chr2:178229352 A/G cg23306229 chr2:178417860 TTC30B -0.54 -6.97 -0.39 2.51e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7508679 1.000 rs7248104 chr19:7224431 A/G cg00428638 chr19:7224713 INSR 0.55 8.71 0.47 3.34e-16 Hypothyroidism; CESC cis rs826838 0.904 rs10880981 chr12:38763911 G/A cg13010199 chr12:38710504 ALG10B 0.62 8.74 0.47 2.7e-16 Heart rate; CESC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg16325326 chr1:53192061 ZYG11B -0.88 -14.98 -0.68 3.69e-37 Monocyte count; CESC cis rs5758659 0.714 rs133376 chr22:42466905 C/T cg04733989 chr22:42467013 NAGA 0.41 5.53 0.32 7.61e-8 Cognitive function; CESC cis rs7845219 0.544 rs9643350 chr8:95917276 C/A cg16049864 chr8:95962084 TP53INP1 -0.47 -6.91 -0.39 3.49e-11 Type 2 diabetes; CESC cis rs9467711 0.606 rs9379854 chr6:26362854 T/C cg12826209 chr6:26865740 GUSBL1 0.62 5.31 0.31 2.27e-7 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15472170 chr1:12012720 PLOD1 -0.55 -6.43 -0.37 5.93e-10 Gut microbiome composition (summer); CESC cis rs11051970 0.592 rs11052002 chr12:32590854 T/A cg24626660 chr12:32551988 NA 0.36 5.21 0.3 3.77e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3857067 0.772 rs10516947 chr4:95110897 A/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC cis rs7666738 0.791 rs11735105 chr4:98937357 C/T cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02671019 chr1:24829462 RCAN3 -0.44 -6.01 -0.35 6.21e-9 Fibrinogen levels; CESC cis rs2997447 0.633 rs11247848 chr1:26357667 G/A cg19633962 chr1:26362018 EXTL1 -0.57 -5.6 -0.33 5.4e-8 QRS complex (12-leadsum); CESC cis rs1552244 0.554 rs2272121 chr3:10047680 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 7.99 0.44 4.24e-14 Alzheimer's disease; CESC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs77106637 0.860 rs1552224 chr11:72433098 A/C cg04827223 chr11:72435913 ARAP1 -0.62 -6.53 -0.37 3.25e-10 Type 2 diabetes; CESC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg22764044 chr5:178986830 RUFY1 0.49 7.39 0.41 1.93e-12 Lung cancer; CESC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg19077165 chr18:44547161 KATNAL2 -0.54 -8.01 -0.44 3.56e-14 Personality dimensions; CESC cis rs1506636 1.000 rs635072 chr7:123403255 G/A cg03229431 chr7:123269106 ASB15 0.51 6.76 0.38 8.9e-11 Plateletcrit;Platelet count; CESC cis rs2243480 1.000 rs1723270 chr7:65469830 T/G cg13147721 chr7:65941812 NA -0.9 -8.73 -0.47 2.9e-16 Diabetic kidney disease; CESC cis rs9815354 1.000 rs9865780 chr3:41895802 A/G cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.48e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs950169 0.922 rs11631096 chr15:85100929 G/C cg17507749 chr15:85114479 UBE2QP1 0.56 6.24 0.36 1.7e-9 Schizophrenia; CESC cis rs9486719 0.741 rs976356 chr6:96849437 T/A cg18709589 chr6:96969512 KIAA0776 0.55 5.67 0.33 3.72e-8 Migraine;Coronary artery disease; CESC cis rs2730245 0.636 rs710421 chr7:158668575 T/C cg24397884 chr7:158709396 WDR60 0.7 10.13 0.53 1.3e-20 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04665974 chr16:30103391 TBX6 -0.49 -6.29 -0.36 1.27e-9 Fibrinogen levels; CESC cis rs7829975 0.533 rs13274028 chr8:8729193 A/C cg15556689 chr8:8085844 FLJ10661 0.42 5.18 0.3 4.44e-7 Mood instability; CESC trans rs561341 1.000 rs506766 chr17:30289659 T/C cg20587970 chr11:113659929 NA -1.42 -16.62 -0.71 5.47e-43 Hip circumference adjusted for BMI; CESC cis rs34779708 0.931 rs35886556 chr10:35334985 C/T cg04310649 chr10:35416472 CREM -0.49 -5.83 -0.34 1.57e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg12419862 chr22:24373484 LOC391322 -0.73 -10.35 -0.54 2.67e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18044720 chr4:87857031 AFF1 -0.69 -7.52 -0.42 8.31e-13 Gut microbiome composition (summer); CESC cis rs3733585 0.673 rs6850143 chr4:9958924 T/C cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs1801251 0.963 rs283481 chr2:233648091 A/G cg08000102 chr2:233561755 GIGYF2 0.67 9.28 0.5 6.17e-18 Coronary artery disease; CESC cis rs11785400 0.793 rs1056012 chr8:143740167 A/G cg24634471 chr8:143751801 JRK 0.45 5.75 0.33 2.41e-8 Schizophrenia; CESC cis rs244293 0.701 rs4793783 chr17:53025480 T/C cg19360675 chr17:53046073 COX11;STXBP4 -0.44 -5.85 -0.34 1.48e-8 Menarche (age at onset); CESC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg10351095 chr21:47802916 PCNT 0.46 6.26 0.36 1.55e-9 Testicular germ cell tumor; CESC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg09796270 chr17:17721594 SREBF1 -0.4 -5.47 -0.32 1.04e-7 Total body bone mineral density; CESC cis rs6062302 0.549 rs4809586 chr20:62249402 C/T cg06363034 chr20:62225388 GMEB2 -0.5 -6.41 -0.37 6.66e-10 Glioblastoma; CESC cis rs7917772 0.619 rs2801050 chr10:104509393 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.51 5.94 0.34 9.14e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs4944092 0.793 rs94111 chr11:75915139 A/G cg04588336 chr11:75916460 WNT11 -0.52 -8.5 -0.46 1.44e-15 PR interval; CESC cis rs35110281 0.805 rs2838317 chr21:44991791 A/C cg01579765 chr21:45077557 HSF2BP -0.58 -10.06 -0.53 2.19e-20 Mean corpuscular volume; CESC cis rs1355223 0.966 rs11602318 chr11:34766983 C/T cg11058730 chr11:34937778 PDHX;APIP 0.45 5.91 0.34 1.03e-8 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6088590 0.965 rs6120727 chr20:33374102 T/C cg24642439 chr20:33292090 TP53INP2 0.84 11.76 0.59 5.5e-26 Coronary artery disease; CESC cis rs9790314 1.000 rs1600209 chr3:161038217 A/T cg04691961 chr3:161091175 C3orf57 -0.43 -5.56 -0.32 6.47e-8 Morning vs. evening chronotype; CESC cis rs3125734 0.608 rs7094950 chr10:64019744 T/C cg09941381 chr10:64027924 RTKN2 -0.32 -5.24 -0.31 3.22e-7 Rheumatoid arthritis; CESC cis rs58688157 0.660 rs12797496 chr11:583767 C/T cg02461776 chr11:598696 PHRF1 0.51 5.55 0.32 6.99e-8 Systemic lupus erythematosus; CESC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg23708337 chr7:1209742 NA 0.5 5.63 0.33 4.68e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs478304 0.651 rs11532071 chr11:65500198 C/A cg10518572 chr11:65560635 OVOL1 -0.32 -6.19 -0.36 2.31e-9 Acne (severe); CESC cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.01 0.48 4.16e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs9324022 0.584 rs72698722 chr14:101181881 C/T cg18089426 chr14:101175970 NA 0.59 8.29 0.45 5.59e-15 Plateletcrit; CESC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg27266027 chr21:40555129 PSMG1 0.47 5.41 0.32 1.42e-7 Cognitive function; CESC cis rs9309473 0.500 rs1528169 chr2:73669186 T/C cg20560298 chr2:73613845 ALMS1 0.48 6.92 0.39 3.47e-11 Metabolite levels; CESC cis rs950027 0.549 rs11070452 chr15:45594836 C/A cg21132104 chr15:45694354 SPATA5L1 -0.57 -6.84 -0.39 5.62e-11 Response to fenofibrate (adiponectin levels); CESC cis rs10540 1.000 rs10540 chr11:494662 G/A cg21784768 chr11:537496 LRRC56 -0.54 -5.11 -0.3 6.29e-7 Body mass index; CESC cis rs9815354 0.812 rs17218441 chr3:41987044 A/G cg03022575 chr3:42003672 ULK4 0.68 6.1 0.35 3.75e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg10057126 chr4:77819792 ANKRD56 0.58 8.6 0.47 7.31e-16 Emphysema distribution in smoking; CESC cis rs7267979 1.000 rs2257991 chr20:25270339 C/T cg08601574 chr20:25228251 PYGB -0.37 -5.36 -0.31 1.83e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs10256972 0.900 rs4388364 chr7:1033045 T/G cg07930192 chr7:1003750 NA 0.4 5.36 0.31 1.77e-7 Longevity;Endometriosis; CESC cis rs12477438 0.520 rs1044575 chr2:99812070 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 15.94 0.7 1.46e-40 Chronic sinus infection; CESC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg27170947 chr2:26402098 FAM59B -0.83 -9.3 -0.5 5.43e-18 Gut microbiome composition (summer); CESC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg19723775 chr5:179050963 HNRNPH1 0.43 5.76 0.33 2.31e-8 Lung cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04389328 chr22:20104991 RANBP1;TRMT2A -0.45 -6.27 -0.36 1.43e-9 Ulcerative colitis; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg12639324 chr10:92617735 HTR7 0.44 6.79 0.38 7.38e-11 Post-traumatic stress disorder; CESC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg24503407 chr1:205819492 PM20D1 0.82 13.93 0.65 1.88e-33 Menarche (age at onset); CESC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg06212747 chr3:49208901 KLHDC8B 0.78 12.53 0.61 1.3e-28 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs9584850 0.794 rs17470961 chr13:99135314 A/G cg20750642 chr13:99100586 FARP1 -0.36 -5.59 -0.32 5.6e-8 Neuroticism; CESC cis rs2635047 0.713 rs9952628 chr18:44754651 G/A cg24371990 chr18:44770781 NA 0.41 6.53 0.37 3.3e-10 Educational attainment; CESC cis rs10788264 0.504 rs7898942 chr10:124024608 G/T cg09507567 chr10:124027408 NA -0.39 -5.39 -0.31 1.57e-7 Total body bone mineral density; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg03981592 chr3:86061698 CADM2 0.45 6.05 0.35 4.98e-9 Recombination measurement; CESC trans rs1557351 0.723 rs1942348 chr18:54724697 A/G cg11433624 chr6:7146702 RREB1 0.4 6.48 0.37 4.37e-10 Multiple sclerosis (age of onset); CESC cis rs7772486 0.790 rs2265917 chr6:146212285 A/G cg05347473 chr6:146136440 FBXO30 0.55 7.05 0.4 1.57e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7122539 0.768 rs7931485 chr11:66578635 G/A cg24851651 chr11:66362959 CCS 0.39 5.27 0.31 2.84e-7 HIV-1 susceptibility; CESC cis rs4901869 0.897 rs12878587 chr14:59339378 C/G cg02291164 chr14:59296302 NA 0.45 7.81 0.43 1.3e-13 Panic disorder; CESC cis rs1843834 0.539 rs6713629 chr2:225410973 A/T cg22455342 chr2:225449267 CUL3 0.71 9.84 0.52 1.1e-19 IgE levels in asthmatics (D.p. specific); CESC cis rs3126085 0.778 rs9887901 chr1:152248552 A/C cg03465714 chr1:152285911 FLG -0.45 -5.56 -0.32 6.52e-8 Atopic dermatitis; CESC cis rs116095464 0.614 rs62344292 chr5:244630 G/A cg22857025 chr5:266934 NA -1.27 -18.37 -0.75 3.49e-49 Breast cancer; CESC trans rs9329221 0.513 rs4841296 chr8:10105447 C/G cg15556689 chr8:8085844 FLJ10661 -0.53 -6.35 -0.36 9.15e-10 Neuroticism; CESC cis rs7577696 0.554 rs3769605 chr2:32322456 A/G cg02381751 chr2:32503542 YIPF4 -0.45 -5.48 -0.32 9.83e-8 Inflammatory biomarkers; CESC cis rs4718428 0.705 rs11028 chr7:66276217 T/C cg12165864 chr7:66369176 NA -0.57 -6.4 -0.37 7.18e-10 Corneal structure; CESC trans rs208520 0.690 rs6932475 chr6:66863155 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.92 -0.62 6e-30 Exhaled nitric oxide output; CESC cis rs7178572 0.568 rs7176302 chr15:77671216 C/G cg22256960 chr15:77711686 NA -0.53 -6.79 -0.38 7.5e-11 Type 2 diabetes; CESC cis rs4132509 1.000 rs9782883 chr1:243892532 A/G cg21452805 chr1:244014465 NA 0.47 5.86 0.34 1.39e-8 RR interval (heart rate); CESC cis rs2985684 0.841 rs7158577 chr14:50058633 C/T cg04989706 chr14:50066350 PPIL5 -0.45 -5.05 -0.3 8.23e-7 Carotid intima media thickness; CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg24739457 chr1:205821442 NA 0.47 6.16 0.35 2.69e-9 Menarche (age at onset); CESC cis rs17253792 0.822 rs75555677 chr14:56096429 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.85 8.83 0.48 1.5e-16 Platelet count; CESC cis rs9457247 1.000 rs422694 chr6:167406074 G/T cg07741184 chr6:167504864 NA 0.29 5.31 0.31 2.32e-7 Crohn's disease; CESC cis rs977987 0.836 rs7198873 chr16:75474754 G/A cg03315344 chr16:75512273 CHST6 0.42 6.0 0.35 6.52e-9 Dupuytren's disease; CESC cis rs2880765 0.743 rs11630410 chr15:86004741 T/A cg10818794 chr15:86012489 AKAP13 -0.33 -5.06 -0.3 7.66e-7 Coronary artery disease; CESC cis rs477692 0.935 rs554458 chr10:131427372 A/G cg26102564 chr10:131424627 MGMT 0.38 5.64 0.33 4.41e-8 Response to temozolomide; CESC cis rs425277 0.606 rs3128295 chr1:2068480 C/T cg04315214 chr1:2043799 PRKCZ 0.5 8.03 0.44 3.26e-14 Height; CESC cis rs2735413 0.918 rs4888731 chr16:78080418 A/G cg04733911 chr16:78082701 NA -0.53 -9.11 -0.49 2.11e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs1348850 0.874 rs2166558 chr2:178373652 G/T cg23306229 chr2:178417860 TTC30B 0.65 8.02 0.44 3.42e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9303280 0.806 rs10852936 chr17:38031714 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.4 -0.31 1.49e-7 Self-reported allergy; CESC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg17158414 chr2:27665306 KRTCAP3 -0.26 -5.28 -0.31 2.7e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg11247378 chr22:39784982 NA -0.63 -8.49 -0.46 1.52e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01755728 chr3:49449714 TCTA;RHOA 0.61 7.22 0.41 5.6e-12 Gut microbiome composition (summer); CESC cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.83 -12.2 -0.6 1.77e-27 Systemic lupus erythematosus; CESC cis rs1008375 0.863 rs7680984 chr4:17600884 A/G cg02297831 chr4:17616191 MED28 0.55 6.96 0.39 2.69e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg17376030 chr22:41985996 PMM1 -0.75 -7.99 -0.44 4.24e-14 Vitiligo; CESC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg06505273 chr16:24850292 NA -0.52 -5.93 -0.34 9.48e-9 Intelligence (multi-trait analysis); CESC cis rs10242455 0.702 rs59240302 chr7:99072991 C/G cg25640893 chr7:99214727 ZNF498 0.69 5.12 0.3 5.75e-7 Blood metabolite levels; CESC cis rs7107174 0.892 rs10899482 chr11:78060081 A/C cg02023728 chr11:77925099 USP35 0.38 5.3 0.31 2.47e-7 Testicular germ cell tumor; CESC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg24675658 chr1:53192096 ZYG11B 0.56 7.62 0.42 4.5e-13 Monocyte count; CESC cis rs63406760 1 rs63406760 chr12:123742692 TG/T cg00376283 chr12:123451042 ABCB9 0.7 8.63 0.47 5.59e-16 Allergic disease (asthma, hay fever or eczema); CESC cis rs6088580 0.608 rs1205342 chr20:32921842 C/T cg08999081 chr20:33150536 PIGU -0.64 -11.02 -0.56 1.75e-23 Glomerular filtration rate (creatinine); CESC cis rs7818345 0.967 rs11204040 chr8:19288525 T/A cg11303988 chr8:19266685 CSGALNACT1 0.36 6.63 0.38 1.9e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg24308560 chr3:49941425 MST1R -0.63 -9.02 -0.48 3.95e-17 Intelligence (multi-trait analysis); CESC cis rs897080 0.552 rs1067384 chr2:44644554 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.89 0.34 1.14e-8 Height; CESC cis rs6466055 0.720 rs12668097 chr7:104996472 A/G cg04380332 chr7:105027541 SRPK2 0.41 5.54 0.32 7.35e-8 Schizophrenia; CESC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg02038168 chr22:39784481 NA 0.62 7.91 0.44 6.96e-14 Intelligence (multi-trait analysis); CESC cis rs2708240 0.967 rs2080156 chr7:147571384 G/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.53 -0.32 7.72e-8 QT interval (drug interaction); CESC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg08704250 chr15:31115839 NA 0.64 8.72 0.47 3.03e-16 Huntington's disease progression; CESC cis rs72781680 0.716 rs2712086 chr2:24004739 G/C cg08917208 chr2:24149416 ATAD2B 0.61 5.99 0.35 6.76e-9 Lymphocyte counts; CESC cis rs4460629 0.804 rs56112907 chr1:155070862 C/A cg01019262 chr1:155095195 NA -0.3 -5.05 -0.3 8.13e-7 Serum magnesium levels; CESC cis rs2235642 0.691 rs2281235 chr16:1603535 T/C cg03715980 chr16:1756201 MAPK8IP3 0.38 5.04 0.3 8.44e-7 Coronary artery disease; CESC cis rs1609391 0.561 rs6439675 chr3:136625436 G/A cg15507776 chr3:136538369 TMEM22 0.81 12.07 0.6 5.03e-27 Neuroticism; CESC cis rs57221529 0.766 rs17563576 chr5:560476 A/G cg16447950 chr5:562315 NA -0.7 -7.68 -0.43 3.1e-13 Lung disease severity in cystic fibrosis; CESC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.54 0.37 3.13e-10 Bipolar disorder; CESC cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC cis rs2658782 1.000 rs2658781 chr11:93166368 C/T cg15737290 chr11:93063684 CCDC67 -0.52 -6.65 -0.38 1.66e-10 Pulmonary function decline; CESC cis rs6831352 0.703 rs4235435 chr4:100039578 C/T cg13256891 chr4:100009986 ADH5 0.69 8.13 0.45 1.61e-14 Alcohol dependence; CESC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.3 0.31 2.49e-7 Bipolar disorder; CESC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg19717773 chr7:2847554 GNA12 -0.57 -8.09 -0.44 2.2e-14 Height; CESC cis rs2463822 1.000 rs2513747 chr11:62098735 T/C cg06239285 chr11:62104954 ASRGL1 0.89 8.97 0.48 5.69e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6987853 0.814 rs2923447 chr8:42439848 G/T cg09913449 chr8:42400586 C8orf40 0.45 7.62 0.42 4.56e-13 Mean corpuscular hemoglobin concentration; CESC cis rs701145 0.556 rs355763 chr3:154012881 C/T cg16511985 chr3:153974050 SGEF 0.43 6.08 0.35 4.21e-9 Coronary artery disease; CESC cis rs250677 0.522 rs17109208 chr5:148378475 G/A cg18129178 chr5:148520854 ABLIM3 -0.46 -5.15 -0.3 5.01e-7 Breast cancer; CESC cis rs7223966 1.000 rs2874121 chr17:61731024 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.72 0.38 1.12e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -6.7 -0.38 1.27e-10 Total body bone mineral density; CESC cis rs3793683 0.545 rs12784446 chr10:134589094 T/G cg26818010 chr10:134567672 INPP5A -0.9 -11.16 -0.57 6e-24 Migraine; CESC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg05025164 chr4:1340916 KIAA1530 -0.68 -8.85 -0.48 1.26e-16 Longevity; CESC cis rs7586879 0.681 rs6545790 chr2:25109302 A/G cg01884057 chr2:25150051 NA 0.37 7.1 0.4 1.18e-11 Body mass index; CESC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg08888203 chr3:10149979 C3orf24 0.48 6.18 0.36 2.36e-9 Alzheimer's disease; CESC cis rs6754311 0.773 rs4988226 chr2:136610598 A/G cg07169764 chr2:136633963 MCM6 -0.69 -8.56 -0.47 9.42e-16 Mosquito bite size; CESC cis rs67311347 1.000 rs11720360 chr3:40448397 G/A cg24209194 chr3:40518798 ZNF619 0.51 6.29 0.36 1.29e-9 Renal cell carcinoma; CESC cis rs4481887 0.893 rs7538645 chr1:248478137 C/T cg00666640 chr1:248458726 OR2T12 0.36 5.98 0.34 7.16e-9 Common traits (Other); CESC cis rs938554 0.612 rs9991278 chr4:10002665 A/G cg00071950 chr4:10020882 SLC2A9 0.5 5.9 0.34 1.12e-8 Blood metabolite levels; CESC cis rs5769765 0.955 rs5769761 chr22:50263641 G/T cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs8141529 0.509 rs12628211 chr22:29239250 T/C cg02153584 chr22:29168773 CCDC117 0.58 7.61 0.42 4.73e-13 Lymphocyte counts; CESC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg00149659 chr3:10157352 C3orf10 0.72 9.05 0.49 3.14e-17 Alzheimer's disease; CESC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg11890956 chr21:40555474 PSMG1 1.15 22.21 0.81 1.91e-62 Cognitive function; CESC cis rs2637266 0.626 rs1660914 chr10:78525319 T/A cg18941641 chr10:78392320 NA 0.41 7.54 0.42 7.33e-13 Pulmonary function; CESC cis rs2072499 0.966 rs11587860 chr1:156156951 G/C cg25208724 chr1:156163844 SLC25A44 0.97 17.41 0.73 9.07e-46 Testicular germ cell tumor; CESC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg27165867 chr14:105738592 BRF1 -0.52 -5.66 -0.33 3.92e-8 Mean platelet volume;Platelet distribution width; CESC cis rs2455799 0.634 rs1345160 chr3:15862026 C/T cg16303742 chr3:15540471 COLQ -0.36 -5.6 -0.33 5.46e-8 Mean platelet volume; CESC trans rs7980799 0.649 rs11052732 chr12:33657801 A/G cg26384229 chr12:38710491 ALG10B -0.58 -8.17 -0.45 1.26e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg03676636 chr4:99064102 C4orf37 0.36 5.62 0.33 4.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs8180040 0.932 rs12489046 chr3:47527683 T/G cg27129171 chr3:47204927 SETD2 0.62 9.22 0.49 9.43e-18 Colorectal cancer; CESC cis rs524281 0.861 rs918299 chr11:65927607 C/T cg14036092 chr11:66035641 RAB1B -0.56 -5.81 -0.34 1.78e-8 Electroencephalogram traits; CESC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg19901468 chr14:105411992 AHNAK2 -0.6 -8.79 -0.48 1.91e-16 Rheumatoid arthritis; CESC cis rs7923609 1.000 rs10822149 chr10:64987412 G/A cg01631684 chr10:65280961 REEP3 -0.45 -5.56 -0.32 6.57e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg00120358 chr1:100615552 LRRC39;CCDC76 0.38 6.2 0.36 2.12e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg00074818 chr8:8560427 CLDN23 0.37 5.45 0.32 1.16e-7 Obesity-related traits; CESC cis rs9611565 0.765 rs132915 chr22:41805782 T/C cg06481639 chr22:41940642 POLR3H 0.62 6.52 0.37 3.49e-10 Vitiligo; CESC cis rs9902453 0.967 rs61240589 chr17:28449035 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 8.01 0.44 3.58e-14 Coffee consumption (cups per day); CESC cis rs7512552 0.839 rs6703652 chr1:150465953 T/G cg15654264 chr1:150340011 RPRD2 0.39 5.13 0.3 5.66e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs7666738 0.753 rs10029372 chr4:98859002 T/C cg05340658 chr4:99064831 C4orf37 0.74 10.7 0.55 1.97e-22 Colonoscopy-negative controls vs population controls; CESC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.45 0.77 5.95e-53 Height; CESC cis rs11122449 1 rs11122449 chr1:230300481 C/T cg20703242 chr1:230279135 GALNT2 0.35 5.54 0.32 7.21e-8 Red cell distribution width; CESC cis rs6754311 0.731 rs892715 chr2:136576577 T/C cg15123519 chr2:136567270 LCT 0.33 5.62 0.33 4.81e-8 Mosquito bite size; CESC cis rs13385 0.769 rs17118781 chr5:139642929 C/T cg26211634 chr5:139558579 C5orf32 0.47 5.07 0.3 7.63e-7 Atrial fibrillation; CESC cis rs9430161 0.579 rs11121669 chr1:11039567 T/C cg02454025 chr1:11042201 C1orf127 0.86 13.22 0.63 5.34e-31 Ewing sarcoma; CESC cis rs12824058 0.767 rs4759654 chr12:130815559 A/G cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs734999 0.588 rs2843401 chr1:2528133 T/C cg20673091 chr1:2541236 MMEL1 -0.44 -7.23 -0.41 5.08e-12 Ulcerative colitis; CESC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg25072359 chr17:41440525 NA 0.53 7.84 0.43 1.11e-13 Menopause (age at onset); CESC cis rs899997 0.814 rs28661610 chr15:78985317 G/A cg04896959 chr15:78267971 NA -0.47 -6.46 -0.37 5.02e-10 Coronary artery disease or large artery stroke; CESC trans rs11098499 0.863 rs10019674 chr4:120443489 C/T cg25214090 chr10:38739885 LOC399744 -0.66 -9.07 -0.49 2.81e-17 Corneal astigmatism; CESC cis rs7223966 1.000 rs8075061 chr17:61804723 A/G cg11494091 chr17:61959527 GH2 0.38 5.19 0.3 4.28e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1707322 0.752 rs12062535 chr1:46222880 G/A cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9399137 0.507 rs7754722 chr6:135260303 T/C cg22676075 chr6:135203613 NA -0.58 -7.73 -0.43 2.21e-13 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7508 1.000 rs7508 chr8:17913970 G/A cg18067069 chr8:17937731 ASAH1 -0.43 -5.13 -0.3 5.74e-7 Atrial fibrillation; CESC cis rs3026101 0.723 rs1806248 chr17:5310411 T/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.61 0.33 4.97e-8 Body mass index; CESC cis rs8027181 1.000 rs8030477 chr15:73085815 C/T cg25632853 chr15:73088954 NA 0.37 6.62 0.38 1.97e-10 Triglyceride levels; CESC trans rs7618501 0.633 rs9866695 chr3:50069452 G/T cg21659725 chr3:3221576 CRBN -0.49 -6.67 -0.38 1.52e-10 Intelligence (multi-trait analysis); CESC trans rs57221529 0.766 rs58015612 chr5:580665 A/T cg25482853 chr8:67687455 SGK3 1.0 10.02 0.52 2.96e-20 Lung disease severity in cystic fibrosis; CESC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.62 8.78 0.47 2.09e-16 Electroencephalogram traits; CESC cis rs12142240 0.698 rs10158236 chr1:46820896 G/T cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs2243480 1.000 rs6970243 chr7:65388490 C/A cg18252515 chr7:66147081 NA -1.06 -9.79 -0.52 1.67e-19 Diabetic kidney disease; CESC cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.89 12.15 0.6 2.69e-27 Multiple sclerosis; CESC cis rs7582720 1.000 rs72926769 chr2:203798318 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs12142240 0.698 rs72677587 chr1:46813982 G/A cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg25985355 chr7:65971099 NA 0.33 5.41 0.32 1.39e-7 Aortic root size; CESC cis rs2304069 0.659 rs216141 chr5:149443994 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.48 -6.57 -0.37 2.64e-10 HIV-1 control; CESC cis rs71277158 0.688 rs56316750 chr3:169782754 G/A cg04067573 chr3:169899625 PHC3 0.73 7.26 0.41 4.37e-12 Prostate cancer; CESC cis rs7772486 0.817 rs9322047 chr6:146400394 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.59 0.38 2.32e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7116495 0.609 rs7111379 chr11:71826319 C/T cg26138937 chr11:71823887 C11orf51 1.22 7.75 0.43 2.02e-13 Severe influenza A (H1N1) infection; CESC cis rs6740322 0.895 rs6710656 chr2:43566941 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -7.38 -0.41 2.08e-12 Coronary artery disease; CESC cis rs2463822 1.000 rs118049526 chr11:62107508 C/T cg06239285 chr11:62104954 ASRGL1 -1.03 -8.95 -0.48 6.23e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs73206853 0.764 rs16940881 chr12:110937818 G/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.59 0.32 5.78e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg25204440 chr1:209979598 IRF6 0.75 12.39 0.61 4.04e-28 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg06456125 chr7:65229604 NA 0.4 5.38 0.31 1.64e-7 Calcium levels; CESC cis rs4660306 1.000 rs1044717 chr1:45976587 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.65 -0.43 3.77e-13 Homocysteine levels; CESC cis rs710216 0.917 rs900834 chr1:43412343 A/G cg03128534 chr1:43423976 SLC2A1 -0.56 -6.53 -0.37 3.37e-10 Red cell distribution width; CESC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg06108461 chr20:60628389 TAF4 -0.92 -14.55 -0.67 1.22e-35 Body mass index; CESC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg04025307 chr7:1156635 C7orf50 0.42 5.99 0.35 6.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg05340658 chr4:99064831 C4orf37 0.81 12.16 0.6 2.51e-27 Colonoscopy-negative controls vs population controls; CESC cis rs910316 1.000 rs4899546 chr14:75594946 G/C cg16144293 chr14:75469539 EIF2B2 -0.39 -5.04 -0.3 8.76e-7 Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23697400 chr5:64064613 SDCCAG10;SFRS12IP1 -0.45 -6.1 -0.35 3.77e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7989336 0.612 rs8001097 chr13:96945882 C/A cg02571835 chr13:96230311 CLDN10 -0.37 -5.33 -0.31 2.09e-7 Obesity; CESC cis rs9911578 0.935 rs2302189 chr17:56584205 A/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.42 -5.5 -0.32 8.99e-8 Intelligence (multi-trait analysis); CESC trans rs7615952 0.932 rs13065725 chr3:125632289 C/A cg07211511 chr3:129823064 LOC729375 -1.08 -13.68 -0.64 1.38e-32 Blood pressure (smoking interaction); CESC cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg03060546 chr3:49711283 APEH 0.43 5.34 0.31 2.05e-7 Parkinson's disease; CESC trans rs7937682 0.855 rs571462 chr11:111487106 C/G cg18187862 chr3:45730750 SACM1L 0.48 6.01 0.35 6.26e-9 Primary sclerosing cholangitis; CESC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg11764359 chr7:65958608 NA 0.73 10.55 0.54 5.73e-22 Aortic root size; CESC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg14829155 chr15:31115871 NA -0.76 -10.54 -0.54 6.55e-22 Huntington's disease progression; CESC cis rs2730245 1.000 rs2730245 chr7:158724789 G/C cg15303052 chr7:158526867 ESYT2 0.43 5.16 0.3 4.88e-7 Height; CESC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg19723775 chr5:179050963 HNRNPH1 -0.42 -5.53 -0.32 7.86e-8 Lung cancer; CESC cis rs9287719 1.000 rs9679122 chr2:10751710 T/C cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs854765 0.618 rs8066982 chr17:17851377 T/C cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.57 0.64 3.26e-32 Prudent dietary pattern; CESC cis rs9916302 0.904 rs7210488 chr17:37539819 T/G cg15445000 chr17:37608096 MED1 -0.41 -6.64 -0.38 1.74e-10 Glomerular filtration rate (creatinine); CESC cis rs7580658 0.857 rs2896980 chr2:128139959 T/C cg10021288 chr2:128175891 PROC -0.4 -6.38 -0.36 8.05e-10 Protein C levels; CESC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg17971929 chr21:40555470 PSMG1 0.59 7.8 0.43 1.45e-13 Menarche (age at onset); CESC cis rs4979906 1.000 rs11002244 chr10:79446207 T/C cg07817648 chr10:79422355 NA -0.6 -6.36 -0.36 8.96e-10 Mortality in heart failure; CESC cis rs6752107 1.000 rs13009506 chr2:234175706 A/C cg23050873 chr2:234184376 ATG16L1;SCARNA5 -0.4 -6.1 -0.35 3.77e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg25767906 chr1:53392781 SCP2 0.46 5.94 0.34 8.83e-9 Monocyte count; CESC cis rs4332037 0.851 rs28728306 chr7:1961814 C/A cg23422044 chr7:1970798 MAD1L1 -0.57 -5.99 -0.35 6.71e-9 Bipolar disorder; CESC cis rs9309473 1.000 rs10186501 chr2:73697844 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.24 -0.36 1.7e-9 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01804278 chr11:63894802 MACROD1 -0.53 -6.24 -0.36 1.69e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.591 rs8143066 chr22:46656607 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.68 8.01 0.44 3.75e-14 LDL cholesterol;Cholesterol, total; CESC cis rs863345 0.967 rs11265001 chr1:158488902 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -5.7 -0.33 3.24e-8 Pneumococcal bacteremia; CESC cis rs9324022 0.929 rs9635184 chr14:101173056 C/T cg18089426 chr14:101175970 NA 0.63 7.15 0.4 8.28e-12 Plateletcrit; CESC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg12373951 chr3:133503437 NA 0.42 6.19 0.36 2.33e-9 Iron status biomarkers; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg22741997 chr17:6900356 ALOX12 0.41 6.47 0.37 4.68e-10 Tonsillectomy; CESC cis rs17253792 0.598 rs12880362 chr14:56017929 G/C cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs2273669 0.667 rs76249006 chr6:109366740 G/A cg05315195 chr6:109294784 ARMC2 -0.67 -6.33 -0.36 1.02e-9 Prostate cancer; CESC cis rs7084402 0.565 rs6481407 chr10:60335090 C/T cg07615347 chr10:60278583 BICC1 -0.36 -5.15 -0.3 5.05e-7 Refractive error; CESC cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.35 5.91 0.34 1.03e-8 Hemoglobin concentration; CESC cis rs644799 0.672 rs11021307 chr11:95501407 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.78 11.71 0.58 8.64e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9926296 0.585 rs8058009 chr16:89856439 G/C cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.61 -5.84 -0.34 1.52e-8 Vitiligo; CESC cis rs8092503 0.953 rs2052326 chr18:52489444 G/C cg12377874 chr18:52495404 RAB27B -0.35 -6.04 -0.35 5.21e-9 Childhood body mass index; CESC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg25072359 chr17:41440525 NA 0.46 6.1 0.35 3.77e-9 Menopause (age at onset); CESC cis rs9291683 0.935 rs1860911 chr4:10275057 C/T cg11266682 chr4:10021025 SLC2A9 0.48 8.64 0.47 5.26e-16 Bone mineral density; CESC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg23161317 chr6:28129485 ZNF389 0.42 5.45 0.32 1.17e-7 Depression; CESC cis rs34779708 0.966 rs17499811 chr10:35456215 G/A cg04310649 chr10:35416472 CREM -0.51 -6.27 -0.36 1.43e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9834373 0.887 rs71324630 chr3:78486657 G/A cg06138941 chr3:78371609 NA -0.42 -5.14 -0.3 5.43e-7 Protein quantitative trait loci; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20725256 chr12:133294261 PGAM5 0.48 6.54 0.37 3.18e-10 Fibrinogen levels; CESC cis rs7542091 0.704 rs1108628 chr1:210041150 A/G cg09509183 chr1:209979624 IRF6 0.39 5.52 0.32 8.24e-8 Monobrow; CESC cis rs1371867 0.846 rs1788180 chr8:101333368 A/G cg11906718 chr8:101322791 RNF19A 0.46 5.91 0.34 1.03e-8 Atrioventricular conduction; CESC cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 5.85 0.34 1.46e-8 Eosinophil percentage of white cells; CESC cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg25019033 chr10:957182 NA -0.57 -6.07 -0.35 4.38e-9 Eosinophil percentage of granulocytes; CESC cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg07926092 chr13:79233506 RNF219 0.62 7.29 0.41 3.66e-12 Large artery stroke; CESC cis rs147858478 1 rs147858478 chr5:131682785 CCTGAGTT/C cg07395648 chr5:131743802 NA -0.44 -5.83 -0.34 1.61e-8 High light scatter reticulocyte percentage of red cells; CESC cis rs3820068 0.581 rs34453754 chr1:15993208 G/C cg13390004 chr1:15929781 NA 0.33 5.17 0.3 4.59e-7 Systolic blood pressure; CESC cis rs2652822 0.507 rs7176597 chr15:63494482 G/A cg02713581 chr15:63449717 RPS27L 0.47 5.58 0.32 6.07e-8 Metabolic traits; CESC cis rs10089 0.953 rs3805615 chr5:127519049 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.07 0.53 2.04e-20 Ileal carcinoids; CESC cis rs35306767 0.714 rs12762955 chr10:1078782 A/C cg26597838 chr10:835615 NA 0.5 5.35 0.31 1.86e-7 Eosinophil percentage of granulocytes; CESC cis rs6540559 0.673 rs17015330 chr1:210012795 T/G cg22029157 chr1:209979665 IRF6 0.65 7.26 0.41 4.19e-12 Cleft lip with or without cleft palate; CESC cis rs2046867 0.818 rs1502754 chr3:72895345 G/T cg25664220 chr3:72788482 NA -0.44 -6.42 -0.37 6.31e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg24250549 chr1:154909240 PMVK 0.74 11.19 0.57 4.71e-24 Prostate cancer; CESC cis rs1451375 0.794 rs11238134 chr7:50542927 A/C cg14593290 chr7:50529359 DDC -0.51 -5.81 -0.34 1.82e-8 Malaria; CESC cis rs425277 0.583 rs3128334 chr1:2038662 G/A cg23803603 chr1:2058230 PRKCZ -0.35 -6.19 -0.36 2.22e-9 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25180585 chr17:49230756 NME1;NME1-NME2 0.46 6.15 0.35 2.82e-9 Gut microbiota (bacterial taxa); CESC cis rs8111998 0.826 rs4932775 chr19:22766651 A/G cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs2273669 0.667 rs12208578 chr6:109369745 T/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.06 -0.35 4.74e-9 Prostate cancer; CESC cis rs3733585 0.588 rs6449154 chr4:9956404 C/T cg02734326 chr4:10020555 SLC2A9 -0.41 -5.87 -0.34 1.32e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2070488 0.745 rs9838792 chr3:38546726 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.78 -12.49 -0.61 1.89e-28 Electrocardiographic conduction measures; CESC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg25985355 chr7:65971099 NA 0.32 5.23 0.31 3.53e-7 Aortic root size; CESC cis rs7246657 0.943 rs1015848 chr19:37945274 A/C cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg22800045 chr5:56110881 MAP3K1 0.81 9.72 0.51 2.76e-19 Initial pursuit acceleration; CESC cis rs7598759 0.548 rs11693738 chr2:232360484 C/T cg19187155 chr2:232395269 NMUR1 0.61 10.26 0.53 5.03e-21 Noise-induced hearing loss; CESC cis rs6500395 0.926 rs2883643 chr16:48693018 C/G cg04672837 chr16:48644449 N4BP1 0.47 5.52 0.32 8.02e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs28386778 0.965 rs2854154 chr17:61981696 C/A cg22520471 chr17:61851767 DDX42;CCDC47 -0.88 -13.1 -0.63 1.46e-30 Prudent dietary pattern; CESC cis rs9837602 1.000 rs6790535 chr3:99807735 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 6.48 0.37 4.54e-10 Breast cancer; CESC cis rs4237845 0.636 rs11172371 chr12:58286188 C/T cg02175503 chr12:58329896 NA 0.6 7.13 0.4 9.58e-12 Intelligence (multi-trait analysis); CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg01238044 chr22:24384105 GSTT1 -0.7 -9.26 -0.49 7.25e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2073300 0.609 rs6137941 chr20:23400848 G/A cg16736954 chr20:23401023 NAPB 0.77 5.65 0.33 4.24e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs847577 0.587 rs34307903 chr7:97728449 C/A cg24562669 chr7:97807699 LMTK2 0.81 13.36 0.63 1.77e-31 Breast cancer; CESC cis rs9291683 0.620 rs7699512 chr4:10125808 C/T cg00071950 chr4:10020882 SLC2A9 -0.56 -8.54 -0.46 1.07e-15 Bone mineral density; CESC trans rs28549925 0.590 rs17136923 chr7:16991838 G/A cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.74e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs7635838 0.718 rs2248971 chr3:11403441 T/C cg00170343 chr3:11313890 ATG7 0.5 7.05 0.4 1.57e-11 HDL cholesterol; CESC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg24829409 chr8:58192753 C8orf71 0.59 7.14 0.4 9.02e-12 Developmental language disorder (linguistic errors); CESC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.56 7.28 0.41 3.9e-12 Tonsillectomy; CESC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.34 0.41 2.56e-12 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25179358 chr12:49741623 DNAJC22 0.56 6.51 0.37 3.73e-10 Gut microbiome composition (summer); CESC cis rs13040088 1.000 rs2273412 chr20:61553802 G/A cg23096297 chr20:61557774 DIDO1 0.99 10.8 0.55 9.12e-23 Menopause (age at onset); CESC cis rs2286503 0.966 rs6949233 chr7:22858191 T/G cg13679077 chr7:22862647 TOMM7 0.4 5.19 0.3 4.26e-7 Fibrinogen; CESC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg26441486 chr22:50317300 CRELD2 0.42 5.34 0.31 2.02e-7 Schizophrenia; CESC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg12648201 chr2:27665141 KRTCAP3 -0.28 -5.5 -0.32 8.99e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg10150615 chr22:24372951 LOC391322 -0.58 -7.92 -0.44 6.72e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg20476274 chr7:133979776 SLC35B4 0.68 10.07 0.53 2.09e-20 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26290973 chr17:78897137 RPTOR -0.52 -6.01 -0.35 6.03e-9 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg23758822 chr17:41437982 NA 1.03 15.41 0.69 1.08e-38 Menopause (age at onset); CESC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg09359103 chr1:154839909 KCNN3 -0.66 -12.18 -0.6 2.2e-27 Prostate cancer; CESC cis rs9300255 0.568 rs1727300 chr12:123664205 C/T cg00376283 chr12:123451042 ABCB9 0.71 8.92 0.48 7.69e-17 Neutrophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18866267 chr4:3310044 NA 0.43 6.26 0.36 1.52e-9 Fibrinogen levels; CESC trans rs208520 0.690 rs207114 chr6:66791703 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -12.67 -0.61 4.51e-29 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21415969 chr3:123304010 PTPLB 0.58 6.49 0.37 4.24e-10 Gut microbiome composition (summer); CESC cis rs1538970 0.924 rs3790582 chr1:45887288 T/C cg05343316 chr1:45956843 TESK2 0.87 12.0 0.59 9.05e-27 Platelet count; CESC cis rs17253792 0.822 rs10135426 chr14:56054644 A/G cg01858014 chr14:56050164 KTN1 -0.82 -6.43 -0.37 5.88e-10 Putamen volume; CESC cis rs9399135 0.967 rs9376085 chr6:135371224 T/C cg22676075 chr6:135203613 NA 0.5 7.06 0.4 1.43e-11 Red blood cell count; CESC cis rs7945705 0.837 rs10769981 chr11:9024460 T/C cg09997546 chr11:8931473 C11orf17;ST5 0.34 5.69 0.33 3.31e-8 Hemoglobin concentration; CESC cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg16339924 chr4:17578868 LAP3 0.65 8.27 0.45 6.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2011503 0.941 rs17751061 chr19:19413092 C/T cg11584989 chr19:19387371 SF4 0.61 7.28 0.41 3.73e-12 Bipolar disorder; CESC cis rs1797081 0.967 rs780633 chr10:16863161 C/T cg23933602 chr10:16859644 RSU1 1.11 25.59 0.84 1.41e-73 Platelet distribution width; CESC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.81 0.34 1.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11098499 0.691 rs10028773 chr4:120265259 C/G cg09307838 chr4:120376055 NA -0.76 -9.9 -0.52 7.03e-20 Corneal astigmatism; CESC cis rs1691799 0.867 rs1168309 chr12:66726439 A/G cg16791601 chr12:66731901 HELB 0.77 13.71 0.64 1.04e-32 White blood cell count (basophil); CESC cis rs79349575 0.783 rs12453374 chr17:46994846 G/C cg16584676 chr17:46985605 UBE2Z 0.53 6.59 0.38 2.42e-10 Type 2 diabetes; CESC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg12483801 chr4:183727862 NA 0.69 6.76 0.38 8.68e-11 Pediatric autoimmune diseases; CESC cis rs12368653 0.557 rs903067 chr12:58011857 G/A cg18357645 chr12:58087776 OS9 -0.36 -5.05 -0.3 8.41e-7 Multiple sclerosis; CESC cis rs9303401 0.614 rs34058624 chr17:57118121 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.89 11.06 0.56 1.21e-23 Cognitive test performance; CESC cis rs6502050 0.865 rs8079388 chr17:80162798 C/A cg23985595 chr17:80112537 CCDC57 -0.4 -6.48 -0.37 4.35e-10 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09312767 chr1:29063505 YTHDF2 0.66 7.37 0.41 2.12e-12 Gut microbiome composition (summer); CESC cis rs6460942 0.732 rs73677575 chr7:12286532 A/G cg06484146 chr7:12443880 VWDE -0.59 -6.3 -0.36 1.25e-9 Coronary artery disease; CESC trans rs6700559 0.810 rs2808248 chr1:200592275 T/C cg05185519 chr16:2972941 FLYWCH1 0.5 6.51 0.37 3.76e-10 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18565702 chr13:113241891 TUBGCP3 -0.52 -6.43 -0.37 6.07e-10 Ulcerative colitis; CESC trans rs6011002 0.816 rs6010991 chr20:62281580 C/T cg17720233 chr1:151128310 TNFAIP8L2 0.83 6.05 0.35 4.81e-9 Dental caries; CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg26668828 chr6:292823 DUSP22 -0.71 -9.32 -0.5 4.65e-18 Menopause (age at onset); CESC cis rs9324022 0.722 rs72698709 chr14:101165747 C/T cg18089426 chr14:101175970 NA 0.55 5.64 0.33 4.41e-8 Plateletcrit; CESC cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg11366901 chr6:160182831 ACAT2 0.83 10.52 0.54 7.54e-22 Age-related macular degeneration (geographic atrophy); CESC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg05368731 chr17:41323189 NBR1 0.8 10.68 0.55 2.21e-22 Menopause (age at onset); CESC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs9818758 0.607 rs11552724 chr3:49156473 C/G cg00383909 chr3:49044727 WDR6 0.89 6.56 0.37 2.82e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs68170813 0.559 rs6949961 chr7:106850755 G/T cg02696742 chr7:106810147 HBP1 0.53 5.06 0.3 7.88e-7 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23654174 chr1:47779667 STIL 0.45 6.14 0.35 2.93e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27127099 chr5:150158597 C5orf62 -0.44 -6.21 -0.36 2.06e-9 Fibrinogen levels; CESC cis rs6456156 0.565 rs12525345 chr6:167478875 T/C cg07741184 chr6:167504864 NA 0.36 6.21 0.36 2.01e-9 Primary biliary cholangitis; CESC cis rs1008375 0.966 rs12503540 chr4:17698781 C/G cg16339924 chr4:17578868 LAP3 -0.52 -6.08 -0.35 4.15e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg05564831 chr3:52568323 NT5DC2 0.46 7.01 0.4 2.03e-11 Bipolar disorder; CESC cis rs7937682 0.889 rs11213969 chr11:111528441 A/G cg09085632 chr11:111637200 PPP2R1B -1.0 -16.54 -0.71 1.09e-42 Primary sclerosing cholangitis; CESC cis rs6541297 1.000 rs6674744 chr1:230279011 C/T cg20703242 chr1:230279135 GALNT2 0.71 11.01 0.56 1.89e-23 Coronary artery disease; CESC cis rs7818345 0.967 rs11787230 chr8:19280982 C/G cg11303988 chr8:19266685 CSGALNACT1 0.36 6.67 0.38 1.53e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg22764044 chr5:178986830 RUFY1 0.43 6.05 0.35 4.98e-9 Lung cancer; CESC cis rs1364705 1.000 rs12676931 chr8:120279927 A/C cg09273054 chr8:120220131 MAL2 -0.61 -7.15 -0.4 8.64e-12 Hippocampal atrophy; CESC cis rs2235642 0.750 rs1894649 chr16:1657284 C/G cg03771183 chr16:1608904 IFT140 0.39 5.8 0.34 1.9e-8 Coronary artery disease; CESC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg02463440 chr8:22132932 PIWIL2 0.39 6.0 0.35 6.34e-9 Hypertriglyceridemia; CESC cis rs7772486 0.782 rs7747576 chr6:146277827 C/T cg05347473 chr6:146136440 FBXO30 -0.56 -7.11 -0.4 1.09e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9611565 0.512 rs5758465 chr22:42175314 T/C cg06481639 chr22:41940642 POLR3H 0.59 5.76 0.33 2.35e-8 Vitiligo; CESC cis rs9815354 0.812 rs73081392 chr3:41923009 G/A cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.93e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs801193 0.548 rs2659904 chr7:66178602 C/A cg10691866 chr7:65817282 TPST1 -0.34 -5.65 -0.33 4.11e-8 Aortic root size; CESC cis rs4604732 0.631 rs35046441 chr1:247626812 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7246657 0.941 rs12982333 chr19:37794724 A/G cg23950597 chr19:37808831 NA -0.58 -6.21 -0.36 2.08e-9 Coronary artery calcification; CESC cis rs2522056 0.932 rs1012793 chr5:131781345 G/C cg24060327 chr5:131705240 SLC22A5 0.64 7.56 0.42 6.71e-13 Lymphocyte counts;Fibrinogen; CESC cis rs6087771 0.926 rs6058431 chr20:30297133 C/T cg13852791 chr20:30311386 BCL2L1 0.82 10.41 0.54 1.7e-21 Subcortical brain region volumes;Putamen volume; CESC cis rs4443100 0.535 rs13055979 chr22:23474085 C/T cg14186256 chr22:23484241 RTDR1 0.55 6.29 0.36 1.33e-9 Serum parathyroid hormone levels; CESC cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg17366294 chr4:99064904 C4orf37 0.55 7.56 0.42 6.57e-13 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 0.802 rs3102336 chr16:89442006 C/T cg02187348 chr16:89574699 SPG7 0.49 6.38 0.36 7.93e-10 Multiple myeloma (IgH translocation); CESC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg19077165 chr18:44547161 KATNAL2 -0.61 -9.05 -0.49 3.22e-17 Personality dimensions; CESC cis rs66573146 0.656 rs66905212 chr4:6949508 G/C cg26116260 chr4:7069785 GRPEL1 -0.83 -5.11 -0.3 6.23e-7 Granulocyte percentage of myeloid white cells; CESC cis rs2204008 0.745 rs12146863 chr12:38502346 G/A cg13010199 chr12:38710504 ALG10B 0.46 5.97 0.34 7.59e-9 Bladder cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14685339 chr14:77787351 POMT2;GSTZ1 0.59 7.7 0.43 2.72e-13 Gut microbiota (bacterial taxa); CESC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.73 -9.22 -0.49 9.33e-18 Alzheimer's disease; CESC cis rs9858542 0.953 rs7623659 chr3:49414791 C/T cg07274523 chr3:49395745 GPX1 0.68 8.44 0.46 2.17e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9308731 0.548 rs7581735 chr2:111937714 T/G cg04202892 chr2:111875749 ACOXL 0.37 5.17 0.3 4.65e-7 Chronic lymphocytic leukemia; CESC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg05872129 chr22:39784769 NA -0.81 -10.75 -0.55 1.29e-22 Intelligence (multi-trait analysis); CESC cis rs6582630 0.537 rs12823925 chr12:38409323 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.98 0.35 7.04e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs3806843 0.966 rs2563261 chr5:140137713 G/T cg16179182 chr5:140090404 VTRNA1-1 0.43 5.62 0.33 4.82e-8 Depressive symptoms (multi-trait analysis); CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04577441 chr4:100870687 LOC256880;H2AFZ -0.48 -5.8 -0.34 1.86e-8 Gut microbiome composition (summer); CESC cis rs8060686 0.641 rs1125332 chr16:68227780 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -5.87 -0.34 1.27e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs4523957 0.855 rs12602764 chr17:2123200 A/T cg16513277 chr17:2031491 SMG6 -0.63 -8.77 -0.47 2.19e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7520050 0.807 rs6656279 chr1:46124088 C/G cg03146154 chr1:46216737 IPP 0.52 6.88 0.39 4.27e-11 Red blood cell count;Reticulocyte count; CESC trans rs17764205 0.777 rs28729385 chr19:3258882 T/C cg03776506 chr16:30581384 ZNF688 -0.72 -6.01 -0.35 6.18e-9 Bipolar disorder and schizophrenia; CESC trans rs877282 0.898 rs36064821 chr10:760952 C/T cg22713356 chr15:30763199 NA 1.13 11.2 0.57 4.33e-24 Uric acid levels; CESC cis rs950776 0.518 rs12910978 chr15:78810017 A/G cg06917634 chr15:78832804 PSMA4 0.78 11.39 0.57 9.64e-25 Sudden cardiac arrest; CESC cis rs11098499 0.954 rs11098524 chr4:120390032 A/G cg09160332 chr4:120329925 NA -0.4 -5.09 -0.3 6.87e-7 Corneal astigmatism; CESC cis rs2243480 0.522 rs1638736 chr7:66092308 A/T cg18252515 chr7:66147081 NA -1.12 -9.13 -0.49 1.86e-17 Diabetic kidney disease; CESC cis rs7208859 0.623 rs11650982 chr17:29129955 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2742234 0.541 rs10899779 chr10:43723976 C/T cg07801480 chr10:43725741 RASGEF1A -0.42 -5.32 -0.31 2.19e-7 Hirschsprung disease; CESC trans rs6091540 0.597 rs35601305 chr20:51077427 A/T cg04610675 chr1:3713158 LRRC47 -0.63 -6.03 -0.35 5.61e-9 Body mass index (joint analysis main effects and smoking interaction);BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index; CESC cis rs11792861 0.926 rs2271878 chr9:111868885 G/A cg05043794 chr9:111880884 C9orf5 -0.42 -6.93 -0.39 3.22e-11 Menarche (age at onset); CESC cis rs7680126 0.596 rs11731652 chr4:10292984 T/C cg00071950 chr4:10020882 SLC2A9 -0.53 -5.99 -0.35 6.88e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.29e-8 Developmental language disorder (linguistic errors); CESC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg21782813 chr7:2030301 MAD1L1 0.49 6.89 0.39 4.07e-11 Bipolar disorder and schizophrenia; CESC cis rs2952156 0.920 rs2934951 chr17:37833328 A/G cg00129232 chr17:37814104 STARD3 -0.74 -10.18 -0.53 9.06e-21 Asthma; CESC cis rs950027 0.787 rs2433616 chr15:45728599 A/G cg21132104 chr15:45694354 SPATA5L1 0.5 5.81 0.34 1.8e-8 Response to fenofibrate (adiponectin levels); CESC cis rs68170813 0.559 rs12537730 chr7:106844281 T/C cg02696742 chr7:106810147 HBP1 -0.53 -5.14 -0.3 5.31e-7 Coronary artery disease; CESC cis rs400736 0.930 rs2745722 chr1:8056669 G/A cg25007680 chr1:8021821 PARK7 0.71 10.24 0.53 5.99e-21 Response to antidepressants and depression; CESC trans rs2727020 0.658 rs7111215 chr11:49430552 T/C cg15704280 chr7:45808275 SEPT13 -0.9 -15.45 -0.69 7.77e-39 Coronary artery disease; CESC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg23172400 chr8:95962367 TP53INP1 -0.44 -9.15 -0.49 1.63e-17 Type 2 diabetes; CESC cis rs9399135 0.869 rs9402675 chr6:135325794 C/G cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg14829155 chr15:31115871 NA -0.76 -10.54 -0.54 6.55e-22 Huntington's disease progression; CESC cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg22875332 chr1:76189707 ACADM 0.72 10.03 0.52 2.87e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4132509 1.000 rs10927040 chr1:243731693 T/C cg21452805 chr1:244014465 NA 0.45 5.5 0.32 8.93e-8 RR interval (heart rate); CESC cis rs722599 0.562 rs2193597 chr14:75234329 G/A cg11812906 chr14:75593930 NEK9 0.47 5.73 0.33 2.76e-8 IgG glycosylation; CESC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg00166722 chr3:10149974 C3orf24 0.49 6.13 0.35 3.24e-9 Alzheimer's disease; CESC cis rs72945132 0.882 rs12295111 chr11:70131882 C/A cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs6772849 0.805 rs13325747 chr3:128336023 G/A cg16766828 chr3:128327626 NA -0.31 -5.19 -0.3 4.14e-7 Monocyte percentage of white cells;Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08930741 chr1:59369549 NA 0.58 6.27 0.36 1.44e-9 Gut microbiome composition (summer); CESC cis rs7647973 0.626 rs9830730 chr3:49675875 G/C cg06212747 chr3:49208901 KLHDC8B 0.64 7.75 0.43 1.94e-13 Menarche (age at onset); CESC cis rs55871839 0.559 rs4737527 chr8:59823491 A/G cg07426533 chr8:59803705 TOX 0.45 6.03 0.35 5.45e-9 Pneumonia; CESC cis rs9403521 1.000 rs116980222 chr6:143998987 C/T cg21026257 chr6:143998961 PHACTR2 0.46 5.03 0.3 8.98e-7 Obesity-related traits; CESC cis rs7918232 0.627 rs10829165 chr10:27319465 A/G cg14240646 chr10:27532245 ACBD5 -0.5 -5.72 -0.33 2.84e-8 Breast cancer; CESC cis rs7843479 0.601 rs11785043 chr8:21810377 C/T cg17168535 chr8:21777572 XPO7 0.74 11.73 0.58 7.12e-26 Mean corpuscular volume; CESC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg11764359 chr7:65958608 NA -0.79 -11.67 -0.58 1.16e-25 Aortic root size; CESC cis rs6598955 0.671 rs55791848 chr1:26582711 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC cis rs6967414 0.681 rs11979878 chr7:6753803 A/G cg00387323 chr7:6746715 ZNF12 0.59 5.78 0.33 2.14e-8 Hematocrit;Hemoglobin concentration; CESC cis rs4253772 0.591 rs11703435 chr22:46685563 C/T cg00784671 chr22:46762841 CELSR1 -0.57 -5.5 -0.32 8.75e-8 LDL cholesterol;Cholesterol, total; CESC cis rs113835537 0.597 rs3737525 chr11:66306355 A/G cg22134325 chr11:66188745 NPAS4 0.45 6.69 0.38 1.29e-10 Airway imaging phenotypes; CESC cis rs7605827 0.930 rs2241237 chr2:15656157 A/T cg19274914 chr2:15703543 NA 0.37 6.68 0.38 1.43e-10 Educational attainment (years of education); CESC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg19468946 chr17:37922297 IKZF3 0.41 5.42 0.32 1.37e-7 Glomerular filtration rate (creatinine); CESC cis rs1559088 0.847 rs7254758 chr19:33608047 T/A cg17764715 chr19:33622953 WDR88 0.46 6.02 0.35 5.63e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2649044 1 rs2649044 chr11:9763969 C/T cg03108697 chr11:9732066 SWAP70 -0.36 -5.46 -0.32 1.12e-7 Diastolic blood pressure; CESC cis rs2370759 1.000 rs76467481 chr10:32610740 T/G cg01819863 chr10:32635814 EPC1 1.1 11.55 0.58 2.99e-25 Sexual dysfunction (female); CESC cis rs10206020 0.842 rs7609325 chr2:1574718 G/A cg12573674 chr2:1569213 NA -0.46 -5.2 -0.3 3.96e-7 IgG glycosylation; CESC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs6754311 0.551 rs6739713 chr2:136488978 A/G cg07169764 chr2:136633963 MCM6 0.6 6.42 0.37 6.25e-10 Mosquito bite size; CESC cis rs12325245 0.536 rs12931051 chr16:58626534 C/T cg05725404 chr16:58534157 NDRG4 -0.63 -5.34 -0.31 2.01e-7 Schizophrenia; CESC cis rs1670533 0.932 rs4690214 chr4:1054636 T/C cg04106633 chr4:1044584 NA 0.41 5.2 0.3 4.01e-7 Recombination rate (females); CESC cis rs10751667 0.666 rs7396677 chr11:958878 C/T cg20946044 chr11:1010712 AP2A2 -0.38 -5.26 -0.31 2.95e-7 Alzheimer's disease (late onset); CESC cis rs2273669 0.667 rs117412830 chr6:109336617 A/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.06 -0.35 4.74e-9 Prostate cancer; CESC cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg02725872 chr8:58115012 NA -0.37 -5.8 -0.34 1.9e-8 Developmental language disorder (linguistic errors); CESC cis rs5769765 0.542 rs5770725 chr22:50256309 C/T cg02269571 chr22:50332266 NA 0.46 5.43 0.32 1.29e-7 Schizophrenia; CESC trans rs208520 0.874 rs208469 chr6:66915891 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.84 -9.91 -0.52 6.69e-20 Exhaled nitric oxide output; CESC cis rs637571 0.726 rs689274 chr11:65665988 A/G cg02427764 chr11:65769310 BANF1;EIF1AD -0.51 -6.5 -0.37 3.91e-10 Eosinophil percentage of white cells; CESC trans rs877282 0.898 rs11253348 chr10:765852 C/T cg22713356 chr15:30763199 NA 1.15 11.2 0.57 4.37e-24 Uric acid levels; CESC trans rs637571 0.522 rs503524 chr11:65751764 C/T cg17712092 chr4:129076599 LARP1B 0.76 10.71 0.55 1.8e-22 Eosinophil percentage of white cells; CESC cis rs9486719 0.857 rs9285393 chr6:97020917 C/A cg18709589 chr6:96969512 KIAA0776 -0.45 -5.22 -0.31 3.57e-7 Migraine;Coronary artery disease; CESC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg18404041 chr3:52824283 ITIH1 -0.37 -6.38 -0.36 7.8e-10 Electroencephalogram traits; CESC cis rs1048238 0.525 rs848214 chr1:16265422 A/G cg22431228 chr1:16359049 CLCNKA 0.37 6.57 0.37 2.6e-10 Systolic blood pressure; CESC cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18088712 chr1:16810147 CROCCL2 0.53 7.08 0.4 1.27e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7312933 0.703 rs10880264 chr12:42586535 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.33 0.36 1.04e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21156815 chr8:22526736 BIN3 -0.45 -6.24 -0.36 1.73e-9 Fibrinogen levels; CESC cis rs11997175 0.624 rs12677772 chr8:33772521 T/C ch.8.33884649F chr8:33765107 NA 0.54 6.71 0.38 1.2e-10 Body mass index; CESC cis rs4764124 0.646 rs2075268 chr12:14956476 A/G cg19759883 chr12:14956454 WBP11;C12orf60 0.58 8.58 0.47 8.3e-16 Pubertal anthropometrics; CESC cis rs11792861 0.855 rs72607165 chr9:111814498 C/T cg13535736 chr9:111863775 C9orf5 -0.52 -6.91 -0.39 3.63e-11 Menarche (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02809263 chr1:70671218 LRRC40;SFRS11 0.49 6.37 0.36 8.38e-10 Gut microbiota (bacterial taxa); CESC trans rs11098499 0.863 rs3775849 chr4:120450908 G/C cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.47e-19 Corneal astigmatism; CESC cis rs6815814 0.950 rs11722813 chr4:38810769 C/T cg02016764 chr4:38805732 TLR1 -0.6 -7.3 -0.41 3.31e-12 Breast cancer; CESC cis rs7772486 0.686 rs9399565 chr6:146081906 G/T cg05347473 chr6:146136440 FBXO30 -0.51 -6.65 -0.38 1.63e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6951245 0.572 rs73264010 chr7:1040477 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.61 -5.43 -0.32 1.24e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg23161317 chr6:28129485 ZNF389 0.48 5.98 0.34 7.37e-9 Depression; CESC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg18305652 chr10:134549665 INPP5A 0.45 6.26 0.36 1.53e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg22875332 chr1:76189707 ACADM -0.6 -7.14 -0.4 8.84e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4604732 0.527 rs60444724 chr1:247623164 T/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.58 7.31 0.41 3.2e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg18357645 chr12:58087776 OS9 -0.43 -5.99 -0.35 6.98e-9 Multiple sclerosis; CESC cis rs2408955 0.522 rs7139330 chr12:48483484 A/C cg24011408 chr12:48396354 COL2A1 -0.48 -7.3 -0.41 3.37e-12 Glycated hemoglobin levels; CESC cis rs10851478 0.529 rs12901929 chr15:49675308 T/C cg08060515 chr15:49448048 GALK2;COPS2 0.54 6.82 0.39 6.08e-11 Oral cavity cancer; CESC cis rs10461617 0.512 rs7715746 chr5:56048837 C/T cg12311346 chr5:56204834 C5orf35 -0.5 -6.19 -0.36 2.31e-9 Type 2 diabetes; CESC cis rs3540 0.618 rs2301832 chr15:91040725 A/T cg10434728 chr15:90938212 IQGAP1 -0.41 -7.27 -0.41 4.01e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs2996428 0.667 rs111640545 chr1:3752792 G/A cg13057898 chr1:3703894 LRRC47 0.45 6.15 0.35 2.86e-9 Red cell distribution width; CESC cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg05347473 chr6:146136440 FBXO30 0.72 9.12 0.49 2e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs6460942 0.597 rs13227809 chr7:12525557 G/A cg10578991 chr7:12443926 VWDE -0.49 -5.13 -0.3 5.63e-7 Coronary artery disease; CESC cis rs17253792 0.822 rs58589065 chr14:56152478 T/C cg01858014 chr14:56050164 KTN1 -0.82 -6.87 -0.39 4.53e-11 Putamen volume; CESC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg07936489 chr17:37558343 FBXL20 -0.78 -11.15 -0.57 6.4e-24 Glomerular filtration rate (creatinine); CESC cis rs9362426 0.887 rs1209113 chr6:88079456 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.48 6.04 0.35 5.08e-9 Depressive episodes in bipolar disorder; CESC cis rs10208940 0.841 rs7581931 chr2:68791641 A/G cg12452813 chr2:68675892 NA 0.52 5.25 0.31 3.12e-7 Urate levels in lean individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11852674 chr15:91478847 UNC45A 0.62 7.17 0.4 7.57e-12 Gut microbiome composition (summer); CESC cis rs7615952 0.866 rs13063119 chr3:125643847 G/A cg05084668 chr3:125655381 ALG1L -0.48 -5.69 -0.33 3.34e-8 Blood pressure (smoking interaction); CESC cis rs9527 0.590 rs10883836 chr10:104891198 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs2228479 0.850 rs11647174 chr16:89958538 G/A cg04013166 chr16:89971882 TCF25 0.76 6.53 0.37 3.28e-10 Skin colour saturation; CESC cis rs3091242 0.728 rs706845 chr1:25730713 G/A cg12412775 chr1:25698385 RHCE -0.31 -5.47 -0.32 1.05e-7 Erythrocyte sedimentation rate; CESC cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg00031303 chr3:195681400 NA -0.4 -5.56 -0.32 6.62e-8 Bronchopulmonary dysplasia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21117678 chr7:101459024 CUX1 0.59 6.61 0.38 2.09e-10 Gut microbiome composition (summer); CESC cis rs9303401 0.538 rs10515155 chr17:56481944 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.94 11.36 0.57 1.25e-24 Cognitive test performance; CESC cis rs12618769 0.597 rs17502889 chr2:99031745 A/G cg10123293 chr2:99228465 UNC50 0.38 5.04 0.3 8.58e-7 Bipolar disorder; CESC cis rs2228479 0.850 rs1800331 chr16:89858417 C/A cg00800038 chr16:89945340 TCF25 -0.9 -7.49 -0.42 1.01e-12 Skin colour saturation; CESC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg27170947 chr2:26402098 FAM59B -0.87 -10.18 -0.53 9.01e-21 Gut microbiome composition (summer); CESC cis rs6460942 0.659 rs13247370 chr7:12514632 T/C cg20607287 chr7:12443886 VWDE -0.64 -7.14 -0.4 9.12e-12 Coronary artery disease; CESC cis rs644799 1.000 rs12786522 chr11:95522858 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.55 0.51 8.96e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10751667 0.643 rs7396767 chr11:938808 G/A cg20946044 chr11:1010712 AP2A2 -0.41 -5.64 -0.33 4.31e-8 Alzheimer's disease (late onset); CESC cis rs9811920 0.529 rs793442 chr3:99581062 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.6 -9.78 -0.51 1.78e-19 Axial length; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23152667 chr5:77072348 TBCA -0.49 -6.39 -0.37 7.45e-10 Ulcerative colitis; CESC cis rs2708240 0.577 rs10233374 chr7:147566772 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 0.4 6.68 0.38 1.37e-10 QT interval (drug interaction); CESC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2243480 0.908 rs4718273 chr7:65216099 G/A cg13147721 chr7:65941812 NA 0.88 8.15 0.45 1.43e-14 Diabetic kidney disease; CESC cis rs820218 0.798 rs2305529 chr17:73702253 G/A cg01592526 chr17:73663357 RECQL5;SAP30BP -0.4 -5.57 -0.32 6.34e-8 Rotator cuff tears; CESC cis rs1707322 0.717 rs28752166 chr1:46213309 G/A cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC cis rs10982213 0.830 rs10739412 chr9:117183166 A/G cg00969271 chr9:117093052 ORM2 0.42 5.83 0.34 1.63e-8 Interleukin-6 levels; CESC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg13264159 chr8:625131 ERICH1 -0.69 -5.18 -0.3 4.44e-7 IgG glycosylation; CESC cis rs2404602 0.735 rs12906143 chr15:76709523 T/A cg00316803 chr15:76480434 C15orf27 0.37 5.07 0.3 7.52e-7 Blood metabolite levels; CESC cis rs992157 1.000 rs992157 chr2:219154781 A/G cg00012203 chr2:219082015 ARPC2 -0.79 -10.7 -0.55 1.9e-22 Colorectal cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08703324 chr15:43785408 TP53BP1 -0.45 -6.71 -0.38 1.18e-10 Gambling; CESC cis rs597583 0.715 rs1940040 chr11:117393294 G/C cg27161313 chr11:117392002 DSCAML1 -0.52 -6.44 -0.37 5.55e-10 Putamen volume; CESC cis rs7408868 0.908 rs2074619 chr19:15276919 G/A cg14696996 chr19:15285081 NOTCH3 1.11 11.51 0.58 3.92e-25 Pulse pressure; CESC cis rs9487051 0.676 rs9400267 chr6:109600164 T/C cg01475377 chr6:109611718 NA -0.44 -6.85 -0.39 5.1e-11 Reticulocyte fraction of red cells; CESC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg05863683 chr7:1912471 MAD1L1 0.37 5.39 0.31 1.53e-7 Bipolar disorder and schizophrenia; CESC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 12.25 0.6 1.24e-27 Platelet count; CESC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg19257562 chr1:2043853 PRKCZ 0.41 6.65 0.38 1.67e-10 Height; CESC cis rs8064299 0.967 rs880827 chr17:72767435 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.64 -9.16 -0.49 1.44e-17 Monocyte count; CESC trans rs11039798 0.588 rs7946443 chr11:48545504 G/A cg03929089 chr4:120376271 NA 0.62 6.07 0.35 4.44e-9 Axial length; CESC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg15445000 chr17:37608096 MED1 -0.43 -7.01 -0.4 1.94e-11 Glomerular filtration rate (creatinine); CESC cis rs2979489 0.945 rs17627903 chr8:30351812 T/C cg26383811 chr8:30366931 RBPMS -0.79 -9.72 -0.51 2.78e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg11764359 chr7:65958608 NA 0.6 7.4 0.41 1.85e-12 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06191203 chr2:152266755 RIF1 0.59 6.75 0.38 9.52e-11 Gut microbiome composition (summer); CESC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs9325144 0.560 rs1601745 chr12:38647828 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.63 -0.51 4.99e-19 Morning vs. evening chronotype; CESC cis rs2247341 0.893 rs743569 chr4:1719620 T/G cg07465881 chr4:1713556 SLBP -0.53 -6.58 -0.37 2.43e-10 Hip circumference adjusted for BMI;Height; CESC cis rs1395 0.571 rs114507490 chr2:27527246 T/A cg22903471 chr2:27725779 GCKR -0.49 -5.98 -0.34 7.31e-9 Blood metabolite levels; CESC cis rs4595586 0.545 rs12833238 chr12:39373898 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs870825 0.698 rs66462315 chr4:185623917 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs1775715 0.870 rs11008696 chr10:32218614 G/A cg18675610 chr10:32216311 ARHGAP12 0.37 5.63 0.33 4.55e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs12136530 0.593 rs12404362 chr1:19739958 A/G cg01832549 chr1:19774989 CAPZB -0.45 -6.22 -0.36 1.97e-9 Lead levels in blood; CESC cis rs2274273 0.662 rs4525413 chr14:55661138 A/T cg04306507 chr14:55594613 LGALS3 0.29 5.05 0.3 8.35e-7 Protein biomarker; CESC cis rs7872515 0.536 rs10992201 chr9:94780754 C/A cg01248375 chr9:94877805 SPTLC1 0.6 5.37 0.31 1.75e-7 Bipolar disorder and schizophrenia; CESC cis rs9486715 0.867 rs4839834 chr6:96882109 C/A cg06623918 chr6:96969491 KIAA0776 0.93 14.47 0.66 2.36e-35 Headache; CESC cis rs734999 0.588 rs2764841 chr1:2529360 G/A cg18854424 chr1:2615690 NA -0.27 -5.45 -0.32 1.14e-7 Ulcerative colitis; CESC cis rs2731664 0.792 rs2731662 chr5:176872494 C/T cg23176889 chr5:176863531 GRK6 0.65 11.47 0.58 5.47e-25 Intelligence (multi-trait analysis); CESC cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg06484146 chr7:12443880 VWDE -0.78 -9.1 -0.49 2.28e-17 Coronary artery disease; CESC cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.47 -7.86 -0.43 9.42e-14 Hemoglobin concentration; CESC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg27266027 chr21:40555129 PSMG1 0.46 5.36 0.31 1.84e-7 Cognitive function; CESC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.3 0.36 1.23e-9 Bipolar disorder; CESC cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg05234568 chr11:5960015 NA -0.56 -6.53 -0.37 3.41e-10 DNA methylation (variation); CESC cis rs2286503 0.780 rs12113458 chr7:22855628 G/T cg13679077 chr7:22862647 TOMM7 0.52 6.65 0.38 1.7e-10 Fibrinogen; CESC cis rs1003719 0.582 rs2835634 chr21:38528270 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.03 -0.44 3.23e-14 Eye color traits; CESC cis rs3806843 1.000 rs4151680 chr5:140186657 A/G cg26395211 chr5:140044315 WDR55 -0.42 -5.33 -0.31 2.07e-7 Depressive symptoms (multi-trait analysis); CESC cis rs4803468 1.000 rs2241709 chr19:41912250 C/T cg14132834 chr19:41945861 ATP5SL -0.58 -7.23 -0.41 5.16e-12 Height; CESC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg16743903 chr16:89593216 SPG7 -0.43 -5.48 -0.32 1.01e-7 Multiple myeloma (IgH translocation); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14415759 chr7:44887690 H2AFV -0.5 -6.16 -0.35 2.65e-9 Ulcerative colitis; CESC cis rs2860975 0.620 rs7898759 chr10:96800354 T/C cg09036531 chr10:96991505 NA -0.37 -5.25 -0.31 3.05e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg19717773 chr7:2847554 GNA12 -0.54 -8.49 -0.46 1.47e-15 Height; CESC cis rs684232 0.644 rs1227030 chr17:619882 C/T cg15660573 chr17:549704 VPS53 -0.65 -8.94 -0.48 6.89e-17 Prostate cancer; CESC cis rs30380 0.506 rs469735 chr5:96130014 T/C cg16492584 chr5:96139282 ERAP1 -0.49 -6.54 -0.37 3.1e-10 Cerebrospinal fluid biomarker levels; CESC cis rs11711311 0.955 rs10934247 chr3:113534941 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.6 8.0 0.44 3.82e-14 IgG glycosylation; CESC cis rs367943 0.712 rs26966 chr5:112740434 T/C cg12552261 chr5:112820674 MCC 0.4 5.31 0.31 2.28e-7 Type 2 diabetes; CESC cis rs950776 0.518 rs62008194 chr15:78813805 G/T cg06917634 chr15:78832804 PSMA4 0.79 11.86 0.59 2.51e-26 Sudden cardiac arrest; CESC cis rs9611565 0.879 rs5758311 chr22:41759375 G/T cg03806693 chr22:41940476 POLR3H -0.73 -8.86 -0.48 1.2e-16 Vitiligo; CESC cis rs9300255 0.602 rs2695478 chr12:123689521 C/T cg00376283 chr12:123451042 ABCB9 0.61 6.48 0.37 4.39e-10 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09639837 chr10:30722502 MAP3K8 0.55 6.15 0.35 2.79e-9 Gut microbiome composition (summer); CESC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg24879335 chr3:133465180 TF 0.37 6.45 0.37 5.33e-10 Iron status biomarkers; CESC cis rs28374715 0.635 rs28557159 chr15:41657353 T/C cg02330683 chr15:41787940 ITPKA 0.43 5.76 0.33 2.29e-8 Ulcerative colitis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg17508018 chr19:40854374 C19orf47;PLD3 -0.46 -6.27 -0.36 1.42e-9 Asthma; CESC cis rs644799 0.965 rs10831430 chr11:95509638 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.94 14.63 0.67 6.13e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs17376456 0.825 rs28412976 chr5:93248377 T/C cg21475434 chr5:93447410 FAM172A 0.8 6.35 0.36 9.43e-10 Diabetic retinopathy; CESC cis rs6976053 0.518 rs314353 chr7:100406144 A/G cg03098644 chr7:100410630 EPHB4 -0.45 -5.87 -0.34 1.31e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg18904891 chr8:8559673 CLDN23 0.44 5.26 0.31 2.98e-7 Parkinson's disease; CESC cis rs1577917 0.958 rs13207354 chr6:86700263 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.82 -0.34 1.67e-8 Response to antipsychotic treatment; CESC cis rs7605827 0.930 rs4668918 chr2:15661992 A/T cg19274914 chr2:15703543 NA 0.38 6.74 0.38 9.73e-11 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09145019 chr1:17972199 ARHGEF10L -0.57 -6.19 -0.36 2.25e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07015081 chr10:22048367 DNAJC1 0.49 6.49 0.37 4.25e-10 Fibrinogen levels; CESC cis rs3105593 1.000 rs56118429 chr15:50923849 T/A cg08437265 chr15:50716283 USP8 0.41 5.32 0.31 2.2e-7 QT interval; CESC cis rs2635047 0.811 rs12958943 chr18:44786818 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 5.58 0.32 6.01e-8 Educational attainment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10705951 chr16:29985294 TAOK2 -0.65 -6.75 -0.38 9.56e-11 Gut microbiome composition (summer); CESC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg13012494 chr21:47604986 C21orf56 0.48 6.47 0.37 4.75e-10 Testicular germ cell tumor; CESC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg03188948 chr7:1209495 NA 0.41 5.21 0.31 3.72e-7 Longevity;Endometriosis; CESC trans rs5756813 0.635 rs4820301 chr22:38126364 G/A cg19894588 chr14:64061835 NA -0.65 -7.41 -0.41 1.7e-12 Optic cup area;Vertical cup-disc ratio; CESC trans rs3780486 0.846 rs7864705 chr9:33140352 A/C cg20290983 chr6:43655470 MRPS18A 0.98 18.78 0.76 1.33e-50 IgG glycosylation; CESC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.25 0.41 4.65e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs12615721 0.534 rs72928187 chr2:81735213 G/A cg06867613 chr15:35838691 ATPBD4 0.75 6.02 0.35 5.66e-9 Pulmonary function decline; CESC cis rs2644899 0.715 rs2607415 chr19:41262687 C/G cg24958765 chr19:41283667 RAB4B -0.59 -6.75 -0.38 9.12e-11 Post bronchodilator FEV1/FVC ratio; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15959319 chr5:32174494 GOLPH3 -0.5 -6.33 -0.36 1.03e-9 Ulcerative colitis; CESC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg21782813 chr7:2030301 MAD1L1 0.42 5.86 0.34 1.38e-8 Schizophrenia; CESC cis rs17376456 0.877 rs13185660 chr5:93336500 G/A cg21475434 chr5:93447410 FAM172A 0.77 6.74 0.38 9.6e-11 Diabetic retinopathy; CESC cis rs9908102 0.740 rs55776918 chr17:12907892 A/G cg26162695 chr17:12921313 ELAC2 0.49 5.34 0.31 1.96e-7 Schizophrenia; CESC cis rs4595586 0.545 rs58154430 chr12:39386649 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.51 0.32 8.37e-8 Morning vs. evening chronotype; CESC cis rs11229555 0.874 rs12800710 chr11:58314540 C/T cg15696309 chr11:58395628 NA -0.4 -5.14 -0.3 5.44e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs9388451 0.874 rs13209968 chr6:126089285 G/C cg05901451 chr6:126070800 HEY2 -0.65 -9.25 -0.49 7.92e-18 Brugada syndrome; CESC cis rs920590 0.758 rs7012358 chr8:19662498 C/T cg17834443 chr8:19674713 INTS10 0.58 6.59 0.38 2.3e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs10876993 0.680 rs2277322 chr12:58009202 T/C cg18357645 chr12:58087776 OS9 -0.54 -8.16 -0.45 1.38e-14 Celiac disease or Rheumatoid arthritis; CESC cis rs12142240 0.698 rs72886907 chr1:46814265 C/T cg00530320 chr1:46809349 NSUN4 0.59 7.85 0.43 1.01e-13 Menopause (age at onset); CESC cis rs425277 1.000 rs262657 chr1:2088577 G/A cg16545954 chr1:2118288 C1orf86 0.33 5.47 0.32 1.02e-7 Height; CESC cis rs7819412 0.715 rs35223712 chr8:11043926 C/T cg21775007 chr8:11205619 TDH -0.37 -5.15 -0.3 5.01e-7 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05985164 chr12:57881757 MARS 0.52 6.46 0.37 5.02e-10 Gut microbiome composition (summer); CESC cis rs6594499 0.872 rs10038058 chr5:110443281 A/G cg04022379 chr5:110408740 TSLP 0.34 5.8 0.34 1.86e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg04944784 chr2:26401820 FAM59B 0.91 9.37 0.5 3.37e-18 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs7657399 chr4:98851861 T/C cg05340658 chr4:99064831 C4orf37 0.74 10.7 0.55 1.97e-22 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg18876405 chr7:65276391 NA -0.57 -7.55 -0.42 6.85e-13 Aortic root size; CESC cis rs11098499 0.754 rs1980025 chr4:120252806 A/G cg09307838 chr4:120376055 NA -0.78 -10.65 -0.55 2.84e-22 Corneal astigmatism; CESC cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg06484146 chr7:12443880 VWDE -0.79 -9.25 -0.49 7.67e-18 Coronary artery disease; CESC cis rs9831754 0.654 rs9837024 chr3:78451637 C/T cg06138941 chr3:78371609 NA 0.5 6.24 0.36 1.76e-9 Calcium levels; CESC cis rs10771431 0.597 rs3759274 chr12:9353875 T/C cg08997352 chr12:9597637 DDX12 -0.7 -8.86 -0.48 1.17e-16 Breast size; CESC cis rs208520 0.633 rs7738469 chr6:66807446 T/C cg07460842 chr6:66804631 NA -1.0 -13.38 -0.63 1.55e-31 Exhaled nitric oxide output; CESC cis rs6500395 1.000 rs3848319 chr16:48610933 T/C cg04672837 chr16:48644449 N4BP1 0.51 6.47 0.37 4.73e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs12477438 0.539 rs720228 chr2:99704547 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.97 0.7 1.12e-40 Chronic sinus infection; CESC cis rs1152591 0.524 rs1255990 chr14:64661523 A/G cg23250157 chr14:64679961 SYNE2 -0.41 -5.73 -0.33 2.79e-8 Atrial fibrillation; CESC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg04248312 chr19:17393744 ANKLE1 -0.92 -15.23 -0.68 4.55e-38 Systemic lupus erythematosus; CESC cis rs2486288 0.656 rs62026703 chr15:45569929 G/T cg21132104 chr15:45694354 SPATA5L1 -0.57 -6.66 -0.38 1.55e-10 Glomerular filtration rate; CESC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg02564969 chr6:151773285 C6orf211;RMND1 0.63 8.67 0.47 4.41e-16 Menarche (age at onset); CESC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg08859206 chr1:53392774 SCP2 0.56 7.29 0.41 3.54e-12 Monocyte count; CESC cis rs8112211 1.000 rs8112211 chr19:38824581 C/T cg14299480 chr19:38876666 GGN -0.44 -6.06 -0.35 4.58e-9 Blood protein levels; CESC cis rs1953600 0.645 rs2819950 chr10:81935279 G/A cg00277334 chr10:82204260 NA 0.56 8.25 0.45 7.41e-15 Sarcoidosis; CESC cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.08 -0.4 1.26e-11 Personality dimensions; CESC cis rs1256061 0.654 rs1256040 chr14:64738394 G/A cg23250157 chr14:64679961 SYNE2 0.46 6.46 0.37 5e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9916302 0.904 rs8079303 chr17:37530755 G/C cg15445000 chr17:37608096 MED1 -0.41 -6.76 -0.38 8.97e-11 Glomerular filtration rate (creatinine); CESC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg18404041 chr3:52824283 ITIH1 -0.4 -6.81 -0.39 6.39e-11 Intelligence (multi-trait analysis); CESC cis rs34779708 0.966 rs1478463 chr10:35473035 G/A cg03585969 chr10:35415529 CREM 0.77 10.56 0.54 5.56e-22 Inflammatory bowel disease;Crohn's disease; CESC cis rs12079745 0.793 rs12092506 chr1:169405517 A/G cg09363564 chr1:169337483 NME7;BLZF1 -1.26 -7.33 -0.41 2.72e-12 QT interval; CESC cis rs9896052 0.559 rs7220850 chr17:73436994 T/C cg25649188 chr17:73499917 CASKIN2 0.48 5.51 0.32 8.56e-8 Sight-threatening diabetic retinopathy in type 2 diabetes; CESC cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.03e-7 Colorectal cancer; CESC cis rs10416265 0.502 rs7245411 chr19:33543029 A/T cg27124370 chr19:33622961 WDR88 0.52 6.96 0.39 2.62e-11 Bone properties (heel); CESC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg16325326 chr1:53192061 ZYG11B -0.57 -8.76 -0.47 2.34e-16 Monocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01755728 chr3:49449714 TCTA;RHOA -0.5 -7.06 -0.4 1.48e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1385374 0.502 rs923077 chr12:129276708 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.6 -5.41 -0.32 1.39e-7 Systemic lupus erythematosus; CESC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg08499158 chr17:42289980 UBTF 0.43 5.15 0.3 5.12e-7 Total body bone mineral density; CESC cis rs4654899 0.785 rs9426736 chr1:21505931 T/G cg05370193 chr1:21551575 ECE1 0.39 6.04 0.35 5.15e-9 Superior frontal gyrus grey matter volume; CESC cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.71 9.36 0.5 3.47e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3820928 0.874 rs6707265 chr2:227849255 T/A cg11843606 chr2:227700838 RHBDD1 -0.49 -6.3 -0.36 1.22e-9 Pulmonary function; CESC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6546550 0.901 rs6546553 chr2:70111711 C/A cg02498382 chr2:70120550 SNRNP27 -0.37 -6.33 -0.36 1.06e-9 Prevalent atrial fibrillation; CESC cis rs897984 0.645 rs9938550 chr16:30999142 A/G cg00531865 chr16:30841666 NA 0.5 6.84 0.39 5.57e-11 Dementia with Lewy bodies; CESC cis rs11031096 0.727 rs7932702 chr11:4124372 C/T cg18678763 chr11:4115507 RRM1 -0.46 -6.26 -0.36 1.58e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs1059312 0.500 rs12303338 chr12:129276641 C/T cg09035930 chr12:129282057 SLC15A4 -0.49 -6.3 -0.36 1.2e-9 Systemic lupus erythematosus; CESC trans rs340849 0.503 rs12733434 chr1:214135997 G/T cg00358451 chr1:249141919 ZNF672 0.44 6.0 0.35 6.54e-9 Alzheimer's disease; CESC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg25405998 chr7:65216604 CCT6P1 0.45 5.15 0.3 4.97e-7 Aortic root size; CESC trans rs459571 1.000 rs459571 chr9:136912626 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.65 -8.37 -0.46 3.35e-15 Platelet distribution width; CESC cis rs2014572 0.510 rs8111661 chr19:57752326 C/G cg12963866 chr19:57752005 ZNF805 0.52 7.21 0.41 5.78e-12 Hyperactive-impulsive symptoms; CESC cis rs3820068 0.581 rs16851876 chr1:15950628 A/T cg13390004 chr1:15929781 NA -0.35 -5.67 -0.33 3.79e-8 Systolic blood pressure; CESC cis rs74181299 0.684 rs11126028 chr2:65338150 C/G cg05010058 chr2:65284262 CEP68 -0.33 -5.21 -0.3 3.75e-7 Pulse pressure; CESC cis rs941873 0.805 rs10762860 chr10:81117794 C/G cg09469691 chr10:81107165 PPIF 0.54 7.25 0.41 4.69e-12 Height; CESC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg25072359 chr17:41440525 NA 0.49 7.46 0.42 1.23e-12 Menopause (age at onset); CESC cis rs9581857 0.725 rs117947621 chr13:28022267 T/C cg22138327 chr13:27999177 GTF3A 0.65 5.16 0.3 4.75e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7666738 0.830 rs880472 chr4:98922595 C/A cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC trans rs10242455 0.557 rs73401516 chr7:99068351 C/A cg09045935 chr12:6379348 NA 0.9 7.62 0.42 4.55e-13 Blood metabolite levels; CESC cis rs962856 0.575 rs4671801 chr2:67622438 A/G cg09028215 chr2:67624308 ETAA1 -0.44 -5.23 -0.31 3.44e-7 Pancreatic cancer; CESC trans rs677673 1.000 rs669016 chr20:10467427 A/G cg16021678 chr13:55475951 NA 0.52 6.68 0.38 1.4e-10 Body mass index (change over time) in chronic obstructive pulmonary disease; CESC cis rs3916 0.955 rs35599677 chr12:121141458 G/A cg21892295 chr12:121157589 UNC119B -0.36 -5.1 -0.3 6.41e-7 Urinary metabolites (H-NMR features); CESC cis rs9649465 0.967 rs13225110 chr7:123340849 C/T cg04330084 chr7:123175371 IQUB -0.39 -5.26 -0.31 2.95e-7 Migraine; CESC cis rs3820928 0.874 rs7594505 chr2:227878562 C/G cg11843606 chr2:227700838 RHBDD1 -0.48 -6.14 -0.35 2.99e-9 Pulmonary function; CESC cis rs400736 0.729 rs2493215 chr1:8007716 C/T cg25007680 chr1:8021821 PARK7 0.58 7.96 0.44 4.95e-14 Response to antidepressants and depression; CESC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg02951883 chr7:2050386 MAD1L1 -0.49 -6.41 -0.37 6.57e-10 Bipolar disorder and schizophrenia; CESC cis rs72901758 0.768 rs55834800 chr17:76252261 G/T cg26068271 chr17:76253126 NA 0.46 6.47 0.37 4.69e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs72901758 0.768 rs11659046 chr17:76245718 G/A cg26068271 chr17:76253126 NA 0.51 7.68 0.43 3.15e-13 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg16545954 chr1:2118288 C1orf86 0.36 7.13 0.4 9.74e-12 Height; CESC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg19193384 chr17:30244184 NA 0.49 5.1 0.3 6.47e-7 Hip circumference adjusted for BMI; CESC cis rs4654899 0.929 rs7515845 chr1:21314455 G/A cg05370193 chr1:21551575 ECE1 0.39 5.85 0.34 1.45e-8 Superior frontal gyrus grey matter volume; CESC cis rs854765 0.647 rs741782 chr17:18019712 T/C cg16928487 chr17:17741425 SREBF1 -0.45 -7.13 -0.4 9.28e-12 Total body bone mineral density; CESC cis rs35110281 0.591 rs230642 chr21:44915533 A/C cg01579765 chr21:45077557 HSF2BP 0.45 7.64 0.42 4.02e-13 Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17630641 chr17:39804879 NA -0.42 -6.22 -0.36 1.92e-9 Gambling; CESC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg09359103 chr1:154839909 KCNN3 -0.62 -11.84 -0.59 3.02e-26 Prostate cancer; CESC cis rs858239 0.600 rs2003555 chr7:23122915 C/T cg23682824 chr7:23144976 KLHL7 0.54 7.58 0.42 5.85e-13 Cerebrospinal fluid biomarker levels; CESC cis rs7662987 1.000 rs6852848 chr4:100001932 A/T cg13256891 chr4:100009986 ADH5 0.75 5.69 0.33 3.41e-8 Smoking initiation; CESC cis rs3015497 0.561 rs4578563 chr14:51159585 G/A cg26011998 chr14:51135199 SAV1 -0.54 -5.82 -0.34 1.71e-8 Mean platelet volume; CESC cis rs4148883 0.504 rs4585310 chr4:100120233 T/C cg13256891 chr4:100009986 ADH5 -0.51 -6.73 -0.38 1.04e-10 Alcohol dependence; CESC cis rs6543140 0.890 rs61122764 chr2:102999520 A/G cg04239558 chr2:103089729 SLC9A4 0.48 6.04 0.35 5.08e-9 Blood protein levels; CESC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg25036284 chr2:26402008 FAM59B -0.86 -9.4 -0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.03 0.4 1.78e-11 Bipolar disorder; CESC cis rs524023 0.874 rs475642 chr11:64424691 C/A cg07220939 chr11:64358617 SLC22A12 -0.35 -5.42 -0.32 1.32e-7 Urate levels in obese individuals; CESC cis rs6951245 0.810 rs117800627 chr7:1081075 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.15 -0.35 2.88e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 0.575 rs4590436 chr8:57996539 A/C cg22535103 chr8:58192502 C8orf71 -0.56 -6.58 -0.37 2.48e-10 Developmental language disorder (linguistic errors); CESC cis rs1008375 1.000 rs10939742 chr4:17659936 G/T cg16339924 chr4:17578868 LAP3 0.55 6.83 0.39 5.81e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24058025 chr1:44412156 IPO13 0.56 6.07 0.35 4.43e-9 Gut microbiome composition (summer); CESC cis rs10197940 0.624 rs10497081 chr2:152353395 T/G cg19508488 chr2:152266495 RIF1 0.51 5.45 0.32 1.17e-7 Lung cancer; CESC cis rs7539624 0.947 rs7524132 chr1:223903500 C/T cg10100437 chr1:223903862 CAPN2 -0.39 -5.73 -0.33 2.71e-8 Schizophrenia; CESC cis rs4835473 0.800 rs4835330 chr4:144767456 T/C cg25736465 chr4:144833511 NA 0.45 6.65 0.38 1.67e-10 Immature fraction of reticulocytes; CESC cis rs2354432 0.556 rs11239965 chr1:146753907 C/A cg25205988 chr1:146714368 CHD1L -0.92 -7.89 -0.44 7.91e-14 Mitochondrial DNA levels; CESC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg08044140 chr6:170176415 C6orf70 -0.4 -5.46 -0.32 1.09e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9560113 0.550 rs1163633 chr13:112231561 G/T cg10483660 chr13:112241077 NA -0.44 -7.48 -0.42 1.07e-12 Menarche (age at onset); CESC cis rs66887589 0.934 rs2715016 chr4:120452356 T/C cg09307838 chr4:120376055 NA -0.52 -6.93 -0.39 3.16e-11 Diastolic blood pressure; CESC cis rs3857536 0.813 rs9354405 chr6:66948575 G/T cg07460842 chr6:66804631 NA -0.42 -5.32 -0.31 2.2e-7 Blood trace element (Cu levels); CESC cis rs9916302 0.706 rs9909304 chr17:37500508 G/T cg07936489 chr17:37558343 FBXL20 0.88 9.63 0.51 5.22e-19 Glomerular filtration rate (creatinine); CESC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.39 -0.31 1.58e-7 Developmental language disorder (linguistic errors); CESC cis rs4803468 1.000 rs284648 chr19:41926790 T/C cg14132834 chr19:41945861 ATP5SL -0.67 -8.35 -0.46 3.74e-15 Height; CESC cis rs72945132 0.825 rs7941965 chr11:70213182 T/C cg00319359 chr11:70116639 PPFIA1 0.72 6.9 0.39 3.72e-11 Coronary artery disease; CESC cis rs754466 0.510 rs10824579 chr10:79590685 C/T cg17075019 chr10:79541650 NA -0.74 -11.98 -0.59 1.04e-26 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs4771450 0.925 rs7333033 chr13:103978262 G/T cg17025674 chr5:127537216 NA -0.5 -6.38 -0.36 7.73e-10 Uric acid levels; CESC cis rs36051895 0.593 rs62541903 chr9:5146952 G/C cg02405213 chr9:5042618 JAK2 -0.5 -6.07 -0.35 4.52e-9 Pediatric autoimmune diseases; CESC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg00684032 chr4:1343700 KIAA1530 0.39 5.46 0.32 1.11e-7 Obesity-related traits; CESC cis rs1707322 1.000 rs4660328 chr1:46444831 G/T cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13771624 chr9:140409915 PNPLA7 0.45 6.45 0.37 5.38e-10 Fibrinogen levels; CESC cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg26769984 chr7:1090371 C7orf50 0.65 7.42 0.41 1.64e-12 Bronchopulmonary dysplasia; CESC cis rs7072216 0.763 rs3814142 chr10:100171104 C/G cg26618903 chr10:100175079 PYROXD2 -0.38 -5.79 -0.34 1.99e-8 Metabolite levels; CESC cis rs8067354 0.540 rs7221472 chr17:58036737 C/T cg13753209 chr17:57696993 CLTC 0.54 5.68 0.33 3.57e-8 Hemoglobin concentration; CESC cis rs62408225 1.000 rs2325291 chr6:90986686 G/A cg06866423 chr6:90926672 BACH2 0.43 5.11 0.3 6.3e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs8014204 0.736 rs2111705 chr14:75261641 G/A cg08847533 chr14:75593920 NEK9 0.42 5.32 0.31 2.22e-7 Caffeine consumption; CESC cis rs7129220 0.512 rs1867138 chr11:10228728 A/G cg01453529 chr11:10209919 SBF2 -0.44 -5.16 -0.3 4.8e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs6062302 0.522 rs914558 chr20:62216976 A/G cg06363034 chr20:62225388 GMEB2 -0.52 -6.57 -0.37 2.61e-10 Glioblastoma; CESC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg04317338 chr11:64019027 PLCB3 0.91 10.17 0.53 1.01e-20 Mean platelet volume; CESC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg16325326 chr1:53192061 ZYG11B 0.85 14.02 0.65 8.69e-34 Monocyte count; CESC cis rs1348850 0.632 rs13008857 chr2:178514468 G/A cg23306229 chr2:178417860 TTC30B 0.6 7.53 0.42 7.75e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg20257372 chr17:1945152 OVCA2;DPH1 -0.47 -6.31 -0.36 1.2e-9 Recombination measurement; CESC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg05617483 chr15:76483344 C15orf27 0.4 5.39 0.31 1.55e-7 Blood metabolite levels; CESC trans rs747782 0.639 rs17198985 chr11:48183565 T/C cg15704280 chr7:45808275 SEPT13 0.7 6.47 0.37 4.83e-10 Intraocular pressure; CESC cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg04455712 chr21:45112962 RRP1B 0.33 5.05 0.3 8.3e-7 Mean corpuscular volume; CESC cis rs4835473 0.897 rs2590034 chr4:144847931 A/G cg25736465 chr4:144833511 NA 0.39 6.0 0.35 6.44e-9 Immature fraction of reticulocytes; CESC cis rs4689592 0.554 rs66925245 chr4:7071999 C/T cg26116260 chr4:7069785 GRPEL1 -0.86 -9.54 -0.51 9.81e-19 Monocyte percentage of white cells; CESC cis rs11098499 1.000 rs7659194 chr4:120207147 T/G cg09307838 chr4:120376055 NA 0.88 11.93 0.59 1.55e-26 Corneal astigmatism; CESC cis rs6540556 0.723 rs11119331 chr1:209889712 G/A cg05527609 chr1:210001259 C1orf107 -0.67 -7.36 -0.41 2.32e-12 Red blood cell count; CESC cis rs8072100 0.688 rs8079142 chr17:45442049 G/A cg25173405 chr17:45401733 C17orf57 -0.44 -5.48 -0.32 9.98e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs11785693 0.862 rs62491171 chr8:4987177 G/A cg26367366 chr8:4980734 NA 0.73 7.3 0.41 3.26e-12 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg11742103 chr11:62369870 EML3;MTA2 0.66 10.04 0.52 2.66e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs35146811 0.735 rs858506 chr7:99820050 T/C cg13215871 chr17:75784724 NA -0.34 -6.39 -0.37 7.46e-10 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26796815 chr5:134094372 DDX46 0.6 7.13 0.4 9.72e-12 Gut microbiome composition (summer); CESC cis rs17095355 1.000 rs12254785 chr10:111699607 C/T cg00817464 chr10:111662876 XPNPEP1 -0.43 -5.23 -0.31 3.37e-7 Biliary atresia; CESC trans rs561341 0.830 rs2301765 chr17:30202056 T/A cg27661571 chr11:113659931 NA 0.6 6.09 0.35 3.88e-9 Hip circumference adjusted for BMI; CESC cis rs3015469 0.626 rs10133759 chr14:51151693 A/C cg26011998 chr14:51135199 SAV1 -0.46 -5.29 -0.31 2.61e-7 Plasma amyloid beta peptide concentrations (ABx-40); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03768513 chr22:24552594 CABIN1 -0.43 -6.48 -0.37 4.55e-10 Gambling; CESC cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.03e-7 Colorectal cancer; CESC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg27170947 chr2:26402098 FAM59B -0.59 -6.98 -0.39 2.31e-11 Gut microbiome composition (summer); CESC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg18758796 chr5:131593413 PDLIM4 0.48 6.97 0.39 2.55e-11 Acylcarnitine levels; CESC cis rs9796 0.558 rs4445868 chr15:41531991 C/T cg20272979 chr15:41787780 ITPKA 0.38 5.56 0.32 6.59e-8 Menopause (age at onset); CESC cis rs7659604 1.000 rs35224452 chr4:122664677 C/T cg19671926 chr4:122722719 EXOSC9 -0.44 -5.19 -0.3 4.27e-7 Type 2 diabetes; CESC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg18016565 chr1:150552671 MCL1 0.34 5.28 0.31 2.67e-7 Tonsillectomy; CESC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.17 0.4 7.34e-12 Height; CESC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg04369109 chr6:150039330 LATS1 -0.41 -5.86 -0.34 1.37e-8 Lung cancer; CESC cis rs798554 1.000 rs798560 chr7:2758309 A/G cg18446336 chr7:2847575 GNA12 -0.36 -5.4 -0.31 1.5e-7 Height; CESC cis rs854765 0.505 rs4506969 chr17:17899839 A/G cg04398451 chr17:18023971 MYO15A -0.71 -10.35 -0.54 2.56e-21 Total body bone mineral density; CESC cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg24110177 chr3:50126178 RBM5 0.54 7.47 0.42 1.2e-12 Body mass index; CESC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs9796 0.621 rs690733 chr15:41476465 G/A cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.41 -0.37 6.77e-10 Menopause (age at onset); CESC cis rs2439831 0.850 rs7183809 chr15:44120868 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.46 0.42 1.21e-12 Lung cancer in ever smokers; CESC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg24829409 chr8:58192753 C8orf71 -0.7 -7.71 -0.43 2.5e-13 Developmental language disorder (linguistic errors); CESC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg24829409 chr8:58192753 C8orf71 -0.75 -9.71 -0.51 2.88e-19 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg04025307 chr7:1156635 C7orf50 0.55 9.79 0.52 1.5700000000000001e-19 Longevity;Endometriosis; CESC cis rs137699 1.000 rs5757632 chr22:39756097 A/C cg05872129 chr22:39784769 NA -0.41 -5.34 -0.31 1.99e-7 IgG glycosylation; CESC cis rs6693567 0.586 rs4970979 chr1:150483840 C/T cg09579323 chr1:150459698 TARS2 0.42 5.3 0.31 2.46e-7 Migraine; CESC cis rs66887589 0.627 rs3872807 chr4:120360251 T/A cg09307838 chr4:120376055 NA 0.53 7.15 0.4 8.37e-12 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25808892 chr17:6459352 PITPNM3 0.54 6.35 0.36 9.53e-10 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg23161317 chr6:28129485 ZNF389 0.52 6.66 0.38 1.53e-10 Depression; CESC cis rs7264396 0.635 rs6060709 chr20:34536022 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.25 -0.57 2.92e-24 Total cholesterol levels; CESC cis rs2228479 0.850 rs17226980 chr16:89825065 G/A cg00800038 chr16:89945340 TCF25 -0.92 -7.67 -0.43 3.37e-13 Skin colour saturation; CESC cis rs854765 0.583 rs11078406 chr17:17840823 G/T cg04398451 chr17:18023971 MYO15A -0.7 -10.37 -0.54 2.22e-21 Total body bone mineral density; CESC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg11663144 chr21:46675770 NA -0.48 -6.53 -0.37 3.28e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9811920 0.638 rs793471 chr3:99546335 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.61 -9.64 -0.51 4.8e-19 Axial length; CESC cis rs6546550 0.935 rs11673826 chr2:70041033 G/A cg02498382 chr2:70120550 SNRNP27 -0.37 -6.38 -0.36 8.01e-10 Prevalent atrial fibrillation; CESC cis rs7927592 0.913 rs10047412 chr11:68232912 T/C cg20283391 chr11:68216788 NA -0.61 -7.28 -0.41 3.81e-12 Total body bone mineral density; CESC cis rs77956314 0.515 rs7302025 chr12:117442902 C/T cg02017074 chr12:117425053 FBXW8 0.77 8.36 0.46 3.66e-15 Subcortical brain region volumes;Hippocampal volume; CESC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.66 0.47 4.81e-16 Electroencephalogram traits; CESC cis rs57221529 0.654 rs12515813 chr5:671826 A/T cg16447950 chr5:562315 NA -0.66 -6.92 -0.39 3.34e-11 Lung disease severity in cystic fibrosis; CESC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg17650747 chr5:1873721 NA 0.41 5.66 0.33 3.83e-8 Cardiovascular disease risk factors; CESC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs2354432 0.505 rs4424556 chr1:146863973 G/C cg25205988 chr1:146714368 CHD1L 1.01 8.93 0.48 7.3e-17 Mitochondrial DNA levels; CESC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.32 -0.31 2.25e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg00166722 chr3:10149974 C3orf24 0.43 5.08 0.3 7.1e-7 Alzheimer's disease; CESC cis rs7312774 1.000 rs7312774 chr12:107305728 G/A cg16260113 chr12:107380972 MTERFD3 0.64 6.07 0.35 4.3e-9 Severe influenza A (H1N1) infection; CESC cis rs7666738 0.830 rs13148363 chr4:98847498 T/C cg05340658 chr4:99064831 C4orf37 0.69 9.73 0.51 2.51e-19 Colonoscopy-negative controls vs population controls; CESC cis rs9467711 0.606 rs9348726 chr6:26605206 G/A cg21479132 chr6:26055353 NA 0.63 5.57 0.32 6.12e-8 Autism spectrum disorder or schizophrenia; CESC trans rs9858542 0.953 rs71324979 chr3:49619651 T/C cg21659725 chr3:3221576 CRBN -0.53 -6.48 -0.37 4.5e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs10751667 1.000 rs12798036 chr11:947585 T/C cg06064525 chr11:970664 AP2A2 -0.39 -7.03 -0.4 1.72e-11 Alzheimer's disease (late onset); CESC cis rs9287719 0.967 rs7587114 chr2:10739963 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs992157 0.796 rs55680399 chr2:219160621 T/C cg00012203 chr2:219082015 ARPC2 0.75 9.97 0.52 4.31e-20 Colorectal cancer; CESC trans rs1998359 0.520 rs177878 chr14:38127890 A/G cg06045799 chr4:47465578 COMMD8 0.52 6.04 0.35 5.23e-9 Self-reported allergy; CESC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg09640425 chr7:158790006 NA -0.36 -5.17 -0.3 4.7e-7 Facial morphology (factor 20); CESC cis rs17253792 0.822 rs74824071 chr14:56095142 T/G cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC trans rs2727020 0.521 rs7131163 chr11:49574774 C/T cg15704280 chr7:45808275 SEPT13 -0.84 -10.3 -0.53 3.95e-21 Coronary artery disease; CESC cis rs6912958 0.559 rs107689 chr6:88069333 G/T cg04972856 chr6:88032051 C6orf162;GJB7 0.35 5.87 0.34 1.3e-8 Monocyte percentage of white cells; CESC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg13607699 chr17:42295918 UBTF 0.58 7.54 0.42 7.45e-13 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10156544 chr12:104324016 LOC253724;HSP90B1 0.63 7.23 0.41 5.17e-12 Gut microbiome composition (summer); CESC cis rs12893668 0.663 rs12889731 chr14:104087482 C/T cg24130564 chr14:104152367 KLC1 -0.48 -6.02 -0.35 5.86e-9 Reticulocyte count; CESC cis rs7116495 0.737 rs661290 chr11:71766014 A/G cg10381502 chr11:71823885 C11orf51 -1.15 -7.18 -0.4 7e-12 Severe influenza A (H1N1) infection; CESC cis rs7666738 0.830 rs880472 chr4:98922595 C/A cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs778371 0.697 rs6717048 chr2:233586427 T/C cg08000102 chr2:233561755 GIGYF2 0.84 14.62 0.67 6.79e-36 Schizophrenia; CESC cis rs2576037 0.796 rs2576039 chr18:44582148 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.45 5.71 0.33 3.02e-8 Personality dimensions; CESC cis rs3733585 0.725 rs6449201 chr4:9973894 C/T cg00071950 chr4:10020882 SLC2A9 -0.69 -11.21 -0.57 3.85e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11785400 0.793 rs10956992 chr8:143736235 A/C cg24634471 chr8:143751801 JRK 0.45 5.86 0.34 1.34e-8 Schizophrenia; CESC cis rs12956009 0.583 rs9653016 chr18:44894189 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.59 0.38 2.42e-10 Educational attainment (years of education); CESC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg14393609 chr7:65229607 NA -0.46 -6.13 -0.35 3.21e-9 Aortic root size; CESC cis rs2070488 1.000 rs1841777 chr3:38484819 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.93 16.68 0.72 3.43e-43 Electrocardiographic conduction measures; CESC trans rs9467711 0.606 rs13203358 chr6:26590578 A/T cg06606381 chr12:133084897 FBRSL1 -0.78 -7.16 -0.4 7.76e-12 Autism spectrum disorder or schizophrenia; CESC cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.07 0.3 7.32e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg05332525 chr7:65337924 VKORC1L1 -0.52 -6.44 -0.37 5.63e-10 Corneal structure; CESC cis rs6976053 0.518 rs314358 chr7:100410657 A/G cg20848291 chr7:100343083 ZAN 0.4 5.5 0.32 9.14e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs919433 0.783 rs787980 chr2:198239225 C/T cg20885578 chr2:198174922 NA 0.4 5.36 0.31 1.8e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs4349753 0.617 rs10061660 chr5:144090021 A/G cg25299750 chr6:35109124 TCP11 0.49 6.04 0.35 5.13e-9 Photic sneeze reflex; CESC cis rs9399135 0.773 rs949895 chr6:135405359 C/T cg22676075 chr6:135203613 NA 0.38 5.06 0.3 8.02e-7 Red blood cell count; CESC cis rs16854884 0.741 rs55909524 chr3:143794734 T/C cg06585982 chr3:143692056 C3orf58 0.44 5.44 0.32 1.24e-7 Economic and political preferences (feminism/equality); CESC cis rs7100689 0.555 rs1934146 chr10:82062121 C/A cg00277334 chr10:82204260 NA -0.61 -8.08 -0.44 2.35e-14 Post bronchodilator FEV1; CESC cis rs4604732 0.631 rs56704806 chr1:247626148 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg15782153 chr7:917662 C7orf20 0.52 5.72 0.33 2.91e-8 Cerebrospinal P-tau181p levels; CESC cis rs17376456 0.825 rs72786702 chr5:93254656 A/C cg25358565 chr5:93447407 FAM172A 1.13 10.44 0.54 1.31e-21 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16773294 chr8:55048378 MRPL15 -0.64 -7.75 -0.43 2.02e-13 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg08888203 chr3:10149979 C3orf24 0.47 5.89 0.34 1.14e-8 Alzheimer's disease; CESC cis rs10887741 0.646 rs11202502 chr10:89437933 C/T cg13926569 chr10:89418898 PAPSS2 0.41 6.04 0.35 5.06e-9 Exercise (leisure time); CESC cis rs2408955 0.542 rs7975632 chr12:48443048 C/T cg24011408 chr12:48396354 COL2A1 0.48 7.22 0.41 5.44e-12 Glycated hemoglobin levels; CESC cis rs2235642 0.928 rs9932984 chr16:1605051 A/G cg08296037 chr16:1584118 IFT140;TMEM204 -0.31 -5.17 -0.3 4.64e-7 Coronary artery disease; CESC cis rs7551222 0.752 rs4252725 chr1:204513256 A/G cg20240347 chr1:204465584 NA -0.26 -5.18 -0.3 4.43e-7 Schizophrenia; CESC cis rs698813 0.674 rs6544751 chr2:44495845 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.54 0.32 7.16e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2204008 0.683 rs11519834 chr12:38053575 T/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs3806843 0.801 rs801171 chr5:140115303 G/A cg26395211 chr5:140044315 WDR55 0.45 6.02 0.35 5.83e-9 Depressive symptoms (multi-trait analysis); CESC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 10.5 0.54 8.5e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6570726 0.935 rs365658 chr6:145844588 C/T cg05347473 chr6:146136440 FBXO30 0.48 6.54 0.37 3.18e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9611565 0.918 rs9611561 chr22:41757234 C/G cg17376030 chr22:41985996 PMM1 0.65 6.95 0.39 2.9100000000000002e-11 Vitiligo; CESC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg25036284 chr2:26402008 FAM59B -0.84 -9.59 -0.51 7.03e-19 Gut microbiome composition (summer); CESC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg13175981 chr1:150552382 MCL1 0.62 9.15 0.49 1.59e-17 Tonsillectomy; CESC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg04025307 chr7:1156635 C7orf50 0.46 5.28 0.31 2.69e-7 Bronchopulmonary dysplasia; CESC cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg14703610 chr5:56206110 C5orf35 0.5 6.63 0.38 1.84e-10 Breast cancer;Breast cancer (early onset); CESC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg08470875 chr2:26401718 FAM59B 0.45 5.19 0.3 4.19e-7 Gut microbiome composition (summer); CESC cis rs10905065 0.898 rs4748916 chr10:5820394 A/G cg11519256 chr10:5708881 ASB13 -0.39 -5.12 -0.3 5.82e-7 Menopause (age at onset); CESC cis rs6964587 0.692 rs2374550 chr7:91820987 A/G cg17063962 chr7:91808500 NA 0.46 6.5 0.37 4.05e-10 Breast cancer; CESC cis rs6831352 0.918 rs13133633 chr4:100058697 C/G cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05321307 chr8:1798729 ARHGEF10 0.46 6.15 0.35 2.9e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20064231 chr18:74608296 ZNF236 0.48 6.4 0.37 6.93e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2832077 0.943 rs2832094 chr21:30165910 G/A cg03476357 chr21:30257390 N6AMT1 -0.49 -5.11 -0.3 6.07e-7 Cognitive test performance; CESC cis rs12144309 0.554 rs1970559 chr1:114377148 T/C cg13572289 chr1:114447746 DCLRE1B;AP4B1 0.44 5.2 0.3 3.99e-7 Coronary artery disease; CESC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg19163074 chr7:65112434 INTS4L2 0.4 5.16 0.3 4.86e-7 Aortic root size; CESC cis rs2979489 0.891 rs17626867 chr8:30311177 G/T cg26383811 chr8:30366931 RBPMS -0.83 -9.83 -0.52 1.25e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs4604732 0.588 rs7552461 chr1:247628644 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.53 6.57 0.37 2.7e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11608355 0.545 rs11613023 chr12:109898047 T/C cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs258892 0.947 rs266436 chr5:72174553 G/A cg21869765 chr5:72125136 TNPO1 0.45 5.6 0.33 5.35e-8 Small cell lung carcinoma; CESC cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg16339924 chr4:17578868 LAP3 0.75 9.36 0.5 3.65e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg00310523 chr12:86230176 RASSF9 0.41 6.23 0.36 1.85e-9 Major depressive disorder; CESC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg23281280 chr6:28129359 ZNF389 0.49 6.77 0.38 8.23e-11 Depression; CESC cis rs113835537 0.529 rs2279864 chr11:66247844 G/A cg24851651 chr11:66362959 CCS 0.46 5.78 0.33 2.12e-8 Airway imaging phenotypes; CESC cis rs8060686 0.920 rs112894876 chr16:67812039 G/C cg26727032 chr16:67993705 SLC12A4 -0.59 -6.16 -0.35 2.69e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs3105593 1.000 rs3131584 chr15:50847401 G/A cg08437265 chr15:50716283 USP8 0.41 5.35 0.31 1.89e-7 QT interval; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02738677 chr3:133265129 NA 0.48 6.53 0.37 3.43e-10 Fibrinogen levels; CESC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg11764359 chr7:65958608 NA 0.89 13.97 0.65 1.29e-33 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23539498 chr22:35654203 HMGXB4 -0.6 -7.47 -0.42 1.14e-12 Gut microbiome composition (summer); CESC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 7.52 0.42 8.32e-13 Total body bone mineral density; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg21934588 chr1:10532847 DFFA -0.46 -6.18 -0.35 2.41e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2637266 0.626 rs2588329 chr10:78552782 C/T cg18941641 chr10:78392320 NA 0.42 7.93 0.44 6.02e-14 Pulmonary function; CESC cis rs709400 0.894 rs56017123 chr14:104075277 G/A cg24130564 chr14:104152367 KLC1 -0.44 -5.25 -0.31 3.06e-7 Body mass index; CESC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg19717773 chr7:2847554 GNA12 -0.57 -7.91 -0.44 7.21e-14 Height; CESC trans rs35110281 0.776 rs9306159 chr21:45061839 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 7.11 0.4 1.1e-11 Mean corpuscular volume; CESC cis rs4561483 0.767 rs33633 chr16:11994857 A/C cg08843971 chr16:11963173 GSPT1 -0.53 -7.9 -0.44 7.4e-14 Testicular germ cell tumor; CESC cis rs6912958 0.559 rs6921504 chr6:88058972 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.47 8.18 0.45 1.18e-14 Monocyte percentage of white cells; CESC cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs10078 0.571 rs2241597 chr5:480509 A/G cg08916839 chr5:415575 AHRR 0.59 7.02 0.4 1.92e-11 Fat distribution (HIV); CESC cis rs68170813 0.559 rs1018947 chr7:106851939 A/T cg02696742 chr7:106810147 HBP1 -0.54 -5.33 -0.31 2.14e-7 Coronary artery disease; CESC cis rs3091242 0.933 rs3093584 chr1:25668714 T/C cg02931644 chr1:25747376 RHCE -0.4 -6.55 -0.37 2.93e-10 Erythrocyte sedimentation rate; CESC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg09509183 chr1:209979624 IRF6 0.38 5.52 0.32 8.15e-8 Monobrow; CESC cis rs1018836 0.786 rs10086401 chr8:91572818 C/T cg16814680 chr8:91681699 NA -0.63 -9.25 -0.49 7.74e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7301826 0.651 rs4759794 chr12:131297348 T/G cg11011512 chr12:131303247 STX2 0.46 5.57 0.32 6.37e-8 Plasma plasminogen activator levels; CESC cis rs6575793 0.904 rs7493050 chr14:101037599 A/G cg18516195 chr14:101012996 BEGAIN 0.46 6.33 0.36 1.02e-9 Menarche (age at onset); CESC cis rs1847202 1.000 rs7634188 chr3:72941289 A/G cg25664220 chr3:72788482 NA 0.38 5.69 0.33 3.35e-8 Motion sickness; CESC cis rs796364 0.806 rs115717210 chr2:201006247 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -6.83 -0.39 5.71e-11 Schizophrenia; CESC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg04772025 chr11:68637568 NA 0.51 6.21 0.36 2.09e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19764399 chr13:48669116 MED4 -0.48 -6.39 -0.37 7.45e-10 Asthma; CESC cis rs7107174 1.000 rs11602622 chr11:78010830 A/G cg02023728 chr11:77925099 USP35 0.42 6.02 0.35 5.91e-9 Testicular germ cell tumor; CESC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs9527 0.637 rs7096169 chr10:104618695 A/G cg15744005 chr10:104629667 AS3MT -0.38 -5.79 -0.34 1.95e-8 Arsenic metabolism; CESC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 5.47 0.32 1.04e-7 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07744562 chr6:90539506 CASP8AP2 -0.4 -6.05 -0.35 4.88e-9 Gambling; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg05299703 chr18:43678513 ATP5A1 -0.47 -6.19 -0.36 2.31e-9 Height; CESC cis rs870825 0.616 rs57086463 chr4:185639525 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC cis rs425277 0.958 rs626479 chr1:2110260 A/G cg16545954 chr1:2118288 C1orf86 -0.34 -5.66 -0.33 3.94e-8 Height; CESC cis rs11997175 0.545 rs5005657 chr8:33668913 C/G ch.8.33884649F chr8:33765107 NA 0.52 6.44 0.37 5.64e-10 Body mass index; CESC cis rs79839061 0.562 rs10516158 chr4:942439 A/G cg07828340 chr4:882639 GAK -1.04 -7.71 -0.43 2.5e-13 Intelligence (multi-trait analysis); CESC trans rs2727020 0.656 rs7925524 chr11:49437542 G/A cg03929089 chr4:120376271 NA -0.68 -8.24 -0.45 7.75e-15 Coronary artery disease; CESC cis rs3749237 0.615 rs55957735 chr3:49438158 G/A cg06212747 chr3:49208901 KLHDC8B 0.53 7.2 0.4 6.14e-12 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19682514 chr1:61549327 NFIA 0.55 6.58 0.37 2.48e-10 Gut microbiome composition (summer); CESC cis rs2952156 0.883 rs12150603 chr17:37834715 G/A cg07936489 chr17:37558343 FBXL20 -0.62 -8.29 -0.45 5.6e-15 Asthma; CESC cis rs6121246 0.559 rs6060915 chr20:30330306 A/G cg13852791 chr20:30311386 BCL2L1 0.84 10.76 0.55 1.19e-22 Mean corpuscular hemoglobin; CESC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.72 -9.4 -0.5 2.65e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9325144 0.624 rs10783329 chr12:39113951 C/T cg26384229 chr12:38710491 ALG10B -0.54 -7.5 -0.42 9.82e-13 Morning vs. evening chronotype; CESC cis rs7208859 0.623 rs9896603 chr17:29078512 C/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs77956314 0.515 rs12299065 chr12:117442304 A/G cg02017074 chr12:117425053 FBXW8 0.78 8.3 0.45 5.2e-15 Subcortical brain region volumes;Hippocampal volume; CESC cis rs2415984 0.622 rs12435397 chr14:46940867 G/A cg14871534 chr14:47121158 RPL10L -0.37 -5.63 -0.33 4.64e-8 Number of children ever born; CESC cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg04455712 chr21:45112962 RRP1B 0.45 7.3 0.41 3.34e-12 Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09351035 chr11:748060 TALDO1 -0.46 -6.5 -0.37 3.89e-10 Gambling; CESC cis rs11958404 0.932 rs72816583 chr5:157432647 T/C cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs1775715 0.835 rs12266771 chr10:32231380 G/A cg04359828 chr10:32216031 ARHGAP12 0.36 5.1 0.3 6.56e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs11098499 0.909 rs10020034 chr4:120294331 A/G cg24375607 chr4:120327624 NA 0.47 5.62 0.33 4.89e-8 Corneal astigmatism; CESC cis rs10752881 1.000 rs10752883 chr1:182980963 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Colorectal cancer; CESC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg20151795 chr6:28129481 ZNF389 0.36 5.07 0.3 7.41e-7 Cardiac Troponin-T levels; CESC trans rs7615952 0.866 rs1976459 chr3:125647486 A/T cg07211511 chr3:129823064 LOC729375 -1.14 -15.22 -0.68 5.24e-38 Blood pressure (smoking interaction); CESC cis rs728616 0.614 rs61859189 chr10:82089250 T/C cg05935833 chr10:81318306 SFTPA2 -0.37 -5.32 -0.31 2.16e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs3791556 0.898 rs3828222 chr2:240109568 A/G cg03281426 chr2:240109471 HDAC4 -0.56 -7.38 -0.41 2.02e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs3806843 0.741 rs4912597 chr5:140106857 C/G cg16179182 chr5:140090404 VTRNA1-1 0.44 5.74 0.33 2.54e-8 Depressive symptoms (multi-trait analysis); CESC cis rs3733585 0.673 rs6814664 chr4:9956228 C/T cg00071950 chr4:10020882 SLC2A9 -0.7 -11.52 -0.58 3.7e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg27494647 chr7:150038898 RARRES2 0.4 5.03 0.3 9.11e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs1707322 0.691 rs11211175 chr1:46220884 C/G cg03146154 chr1:46216737 IPP 0.76 10.91 0.56 4.01e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7264396 0.676 rs6060730 chr20:34558503 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.29 -0.53 4.22e-21 Total cholesterol levels; CESC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg09177884 chr7:1199841 ZFAND2A -0.41 -5.13 -0.3 5.59e-7 Longevity;Endometriosis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14584159 chr10:134351371 INPP5A -0.39 -6.06 -0.35 4.56e-9 Gambling; CESC cis rs1707322 0.655 rs3014240 chr1:46089225 C/G cg03146154 chr1:46216737 IPP -0.79 -11.05 -0.56 1.36e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg01022859 chr17:60767314 MRC2 0.42 6.35 0.36 9.16e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1707322 0.691 rs61784799 chr1:46177748 A/G cg03146154 chr1:46216737 IPP -0.82 -11.53 -0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7809950 0.953 rs2520263 chr7:107179119 T/C cg23024343 chr7:107201750 COG5 -0.43 -6.01 -0.35 6.18e-9 Coronary artery disease; CESC cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 5.52 0.32 8.14e-8 Colorectal cancer; CESC cis rs36051895 0.589 rs7874785 chr9:5196695 C/T cg02405213 chr9:5042618 JAK2 0.51 5.94 0.34 8.88e-9 Pediatric autoimmune diseases; CESC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg18337363 chr3:52569053 NT5DC2 0.28 5.08 0.3 7.06e-7 Electroencephalogram traits; CESC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg18446336 chr7:2847575 GNA12 -0.39 -5.9 -0.34 1.1e-8 Height; CESC trans rs3780486 1.000 rs10813957 chr9:33153527 G/T cg20290983 chr6:43655470 MRPS18A 0.88 11.8 0.59 4.13e-26 IgG glycosylation; CESC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg06456125 chr7:65229604 NA 0.46 5.99 0.35 6.93e-9 Aortic root size; CESC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg05863683 chr7:1912471 MAD1L1 0.42 6.21 0.36 2.09e-9 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs34779708 0.931 rs34375045 chr10:35362356 A/C cg04310649 chr10:35416472 CREM -0.51 -6.02 -0.35 5.75e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9790314 1.000 rs459697 chr3:161093420 G/A cg04691961 chr3:161091175 C3orf57 -0.42 -5.17 -0.3 4.57e-7 Morning vs. evening chronotype; CESC cis rs9584850 0.834 rs3783005 chr13:99111337 A/T cg20750642 chr13:99100586 FARP1 0.36 5.38 0.31 1.61e-7 Neuroticism; CESC cis rs1322639 0.614 rs6937001 chr6:169565086 C/T cg04662567 chr6:169592167 NA 0.46 5.14 0.3 5.32e-7 Pulse pressure; CESC cis rs3747547 0.818 rs11794350 chr9:37947420 C/G cg13774184 chr9:37916125 SHB -0.57 -5.96 -0.34 8.04e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs9549367 0.789 rs9549715 chr13:113908240 G/C cg18105134 chr13:113819100 PROZ -0.72 -8.87 -0.48 1.09e-16 Platelet distribution width; CESC cis rs17376456 0.877 rs13173952 chr5:93307557 A/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.64 5.65 0.33 4.1e-8 Diabetic retinopathy; CESC cis rs977987 0.806 rs8050769 chr16:75388434 C/T cg03315344 chr16:75512273 CHST6 0.4 5.83 0.34 1.61e-8 Dupuytren's disease; CESC cis rs10979 0.964 rs12526234 chr6:143898680 A/T cg25407410 chr6:143891975 LOC285740 -0.61 -9.12 -0.49 1.91e-17 Hypospadias; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14056620 chr7:44836144 PPIA 0.6 6.89 0.39 3.98e-11 Gut microbiome composition (summer); CESC cis rs6912958 0.712 rs6454641 chr6:88371060 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -7.17 -0.4 7.28e-12 Monocyte percentage of white cells; CESC cis rs9549260 0.785 rs10507484 chr13:41218134 T/C cg21288729 chr13:41239152 FOXO1 0.67 8.73 0.47 2.88e-16 Red blood cell count; CESC cis rs1941023 0.503 rs894591 chr11:60132647 T/C cg08716584 chr11:60157161 MS4A7 -0.55 -8.95 -0.48 6.42e-17 Congenital heart disease (maternal effect); CESC cis rs6120849 0.754 rs13433216 chr20:33616301 T/C cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.75 6.54 0.37 3.16e-10 Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19863752 chr5:175970067 NA -0.45 -6.17 -0.35 2.49e-9 Fibrinogen levels; CESC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg10494973 chr17:80897199 TBCD -0.43 -5.05 -0.3 8.33e-7 Breast cancer; CESC cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg22800045 chr5:56110881 MAP3K1 -0.61 -7.83 -0.43 1.21e-13 Initial pursuit acceleration; CESC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg16325326 chr1:53192061 ZYG11B -1.0 -17.81 -0.74 3.35e-47 Monocyte count; CESC trans rs1116547 0.602 rs3846722 chr5:112825424 G/A cg10115368 chr14:100435663 NA 0.5 6.0 0.35 6.41e-9 Cerebral amyloid angiopathy; CESC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg04267008 chr7:1944627 MAD1L1 -0.65 -7.73 -0.43 2.18e-13 Bipolar disorder and schizophrenia; CESC cis rs820218 0.743 rs2053508 chr17:73685659 A/G cg01592526 chr17:73663357 RECQL5;SAP30BP -0.45 -6.13 -0.35 3.18e-9 Rotator cuff tears; CESC cis rs1707322 1.000 rs12124291 chr1:46432132 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16791218 chr16:88105809 BANP -0.6 -6.71 -0.38 1.17e-10 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg26314531 chr2:26401878 FAM59B -0.7 -7.87 -0.44 9.29e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20250570 chr10:1034318 GTPBP4 0.6 6.99 0.39 2.28e-11 Gut microbiome composition (summer); CESC cis rs72945132 0.882 rs7942613 chr11:70210675 C/T cg14191688 chr11:70257035 CTTN 0.43 5.42 0.32 1.34e-7 Coronary artery disease; CESC cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg08213375 chr14:104286397 PPP1R13B 0.32 5.38 0.31 1.64e-7 Reticulocyte count; CESC cis rs7903847 0.619 rs9888116 chr10:99159482 G/A cg20016023 chr10:99160130 RRP12 -0.3 -5.22 -0.31 3.54e-7 Granulocyte percentage of myeloid white cells; CESC trans rs11098499 0.657 rs7664458 chr4:120371967 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs30380 1.000 rs469758 chr5:96121715 C/T cg16492584 chr5:96139282 ERAP1 -0.35 -5.35 -0.31 1.89e-7 Cerebrospinal fluid biomarker levels; CESC cis rs847577 0.677 rs4729403 chr7:97707841 G/C cg21770322 chr7:97807741 LMTK2 -0.48 -7.17 -0.4 7.61e-12 Breast cancer; CESC cis rs2635047 0.811 rs12962421 chr18:44787498 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.51 0.32 8.36e-8 Educational attainment; CESC cis rs9658691 0.607 rs9658788 chr10:90776486 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -5.33 -0.31 2.13e-7 Mosquito bite size; CESC cis rs6752107 1.000 rs6431654 chr2:234161769 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 6.81 0.39 6.56e-11 Crohn's disease;Inflammatory bowel disease; CESC trans rs637571 0.584 rs659824 chr11:65636509 A/G cg17712092 chr4:129076599 LARP1B -0.73 -9.51 -0.5 1.24e-18 Eosinophil percentage of white cells; CESC cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg00033643 chr7:134001901 SLC35B4 0.44 5.6 0.33 5.4e-8 Mean platelet volume; CESC cis rs2404602 0.536 rs12915248 chr15:76765615 A/T cg22467129 chr15:76604101 ETFA -0.38 -5.95 -0.34 8.31e-9 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16354201 chr1:33938307 ZSCAN20 -0.59 -7.12 -0.4 9.92e-12 Gut microbiome composition (summer); CESC cis rs916888 0.821 rs70600 chr17:44860021 C/T cg17911788 chr17:44343683 NA -0.55 -6.95 -0.39 2.86e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg22920501 chr2:26401640 FAM59B -0.86 -10.17 -0.53 1.03e-20 Gut microbiome composition (summer); CESC cis rs2832191 1.000 rs2832183 chr21:30482150 G/A cg08807101 chr21:30365312 RNF160 -0.67 -9.18 -0.49 1.29e-17 Dental caries; CESC cis rs13191362 0.507 rs2023015 chr6:163060528 A/T cg06582575 chr6:163149167 PACRG;PARK2 -0.5 -5.97 -0.34 7.63e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7091068 0.518 rs726817 chr10:95459817 C/T cg20715218 chr10:95462985 C10orf4 0.54 6.65 0.38 1.62e-10 Urinary tract infection frequency; CESC cis rs6580649 0.941 rs11609399 chr12:48501161 A/T cg05342945 chr12:48394962 COL2A1 0.55 6.35 0.36 9.14e-10 Lung cancer; CESC cis rs4720575 1.000 rs4724535 chr7:47100396 G/A cg00036614 chr7:47093842 NA -0.42 -6.48 -0.37 4.39e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs7937682 1.000 rs4936661 chr11:111587495 G/A cg22437258 chr11:111473054 SIK2 -0.67 -7.62 -0.42 4.63e-13 Primary sclerosing cholangitis; CESC cis rs965469 1.000 rs2236087 chr20:3255905 C/T cg25506879 chr20:3388711 C20orf194 -0.57 -5.93 -0.34 9.53e-9 IFN-related cytopenia; CESC cis rs9486719 1.000 rs12207570 chr6:96987884 A/C cg06623918 chr6:96969491 KIAA0776 -0.8 -8.32 -0.46 4.68e-15 Migraine;Coronary artery disease; CESC cis rs9447004 0.583 rs28360541 chr6:74432427 T/G cg23004174 chr6:74404879 CD109 0.36 5.13 0.3 5.67e-7 Blood protein levels;Calcium levels; CESC cis rs8017423 0.967 rs7154683 chr14:90700692 A/G cg14092571 chr14:90743983 NA -0.58 -8.43 -0.46 2.31e-15 Mortality in heart failure; CESC cis rs2625529 0.652 rs8036307 chr15:72175120 A/G cg16672083 chr15:72433130 SENP8 0.47 6.88 0.39 4.35e-11 Red blood cell count; CESC cis rs1670533 0.932 rs2248083 chr4:1052166 A/C cg27284194 chr4:1044797 NA 0.43 5.25 0.31 3.05e-7 Recombination rate (females); CESC cis rs6087771 0.651 rs6060775 chr20:30286191 A/G cg13852791 chr20:30311386 BCL2L1 0.56 6.47 0.37 4.76e-10 Subcortical brain region volumes;Putamen volume; CESC cis rs11249608 0.548 rs11960161 chr5:178453837 A/G cg01312482 chr5:178451176 ZNF879 -0.46 -6.48 -0.37 4.52e-10 Pubertal anthropometrics; CESC cis rs2070488 0.965 rs7640050 chr3:38525864 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.96 17.83 0.74 2.96e-47 Electrocardiographic conduction measures; CESC cis rs60154123 0.730 rs583148 chr1:210463553 A/C cg25204440 chr1:209979598 IRF6 0.45 5.04 0.3 8.61e-7 Coronary artery disease; CESC cis rs1448094 0.872 rs7300073 chr12:86393513 A/C cg02569458 chr12:86230093 RASSF9 0.34 5.16 0.3 4.86e-7 Major depressive disorder; CESC cis rs4481887 1.000 rs4430369 chr1:248464330 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.59 0.38 2.41e-10 Common traits (Other); CESC cis rs9611565 0.512 rs4822052 chr22:42193741 G/A cg03806693 chr22:41940476 POLR3H -1.06 -12.08 -0.6 4.51e-27 Vitiligo; CESC cis rs7937682 0.632 rs2070894 chr11:111780837 G/A cg22437258 chr11:111473054 SIK2 -0.5 -5.6 -0.33 5.39e-8 Primary sclerosing cholangitis; CESC cis rs3733585 0.699 rs6449159 chr4:9960498 G/A cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg27086024 chr14:67982146 TMEM229B -0.47 -6.34 -0.36 1.01e-9 Asthma; CESC cis rs6089584 1.000 rs6089581 chr20:60562394 G/A cg06108461 chr20:60628389 TAF4 -0.78 -11.36 -0.57 1.25e-24 Body mass index; CESC cis rs1499972 0.618 rs62264768 chr3:117642924 T/C cg07612923 chr3:117604196 NA 0.69 6.32 0.36 1.12e-9 Schizophrenia; CESC cis rs1707322 1.000 rs12124291 chr1:46432132 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.55 -0.51 9.12e-19 Alzheimer's disease; CESC cis rs1865721 0.761 rs11660256 chr18:73219532 C/T cg26385618 chr18:73139727 C18orf62 -0.53 -7.75 -0.43 2.02e-13 Intelligence; CESC trans rs997295 0.529 rs12592315 chr15:68040266 A/G cg18012350 chr15:74753669 UBL7 0.52 6.89 0.39 4.05e-11 Motion sickness; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14105000 chr17:55193516 AKAP1 0.41 5.99 0.35 6.69e-9 Fibrinogen levels; CESC cis rs9527 0.590 rs7074395 chr10:104844928 A/C cg04362960 chr10:104952993 NT5C2 -0.44 -5.41 -0.32 1.39e-7 Arsenic metabolism; CESC cis rs9399135 0.967 rs6569990 chr6:135365818 C/T cg24558204 chr6:135376177 HBS1L 0.5 6.85 0.39 5.16e-11 Red blood cell count; CESC trans rs72766638 0.895 rs55924785 chr9:136929586 C/T cg10765909 chr12:53715428 AAAS -0.74 -6.66 -0.38 1.53e-10 Mosquito bite size; CESC cis rs9910055 0.550 rs113844752 chr17:42297631 C/A cg08499158 chr17:42289980 UBTF -0.49 -6.04 -0.35 5.06e-9 Total body bone mineral density; CESC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg03388025 chr16:89894329 SPIRE2 0.39 7.45 0.42 1.29e-12 Vitiligo; CESC cis rs6499255 0.951 rs11642030 chr16:69605211 A/C cg15192750 chr16:69999425 NA 0.53 6.13 0.35 3.22e-9 IgE levels; CESC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.02 0.52 2.97e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg24324837 chr19:49891574 CCDC155 0.48 5.59 0.32 5.74e-8 Multiple sclerosis; CESC cis rs6942756 0.806 rs10248810 chr7:128993806 G/A cg02491457 chr7:128862824 NA -0.6 -8.49 -0.46 1.45e-15 White matter hyperintensity burden; CESC cis rs6089829 1.000 rs6089828 chr20:61668998 C/T cg03213289 chr20:61660250 NA 0.39 5.96 0.34 7.99e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg05368731 chr17:41323189 NBR1 0.78 10.62 0.55 3.44e-22 Menopause (age at onset); CESC cis rs11252926 0.966 rs61831030 chr10:578869 C/T cg18196295 chr10:418757 DIP2C -0.5 -5.67 -0.33 3.69e-8 Psychosis in Alzheimer's disease; CESC cis rs2996428 0.667 rs11578581 chr1:3770642 G/A cg23277830 chr1:3704460 LRRC47 0.34 5.05 0.3 8.41e-7 Red cell distribution width; CESC cis rs1729951 0.575 rs12494558 chr3:136678781 C/G cg04103450 chr3:136751342 NA 0.4 5.39 0.31 1.55e-7 Neuroticism; CESC cis rs1707322 1.000 rs785517 chr1:46567535 A/T cg06784218 chr1:46089804 CCDC17 -0.36 -5.93 -0.34 9.35e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs561341 1.000 rs72821952 chr17:30248133 T/A cg19193384 chr17:30244184 NA -0.64 -5.9 -0.34 1.12e-8 Hip circumference adjusted for BMI; CESC cis rs6866344 0.661 rs72812606 chr5:178129094 A/T cg10224037 chr5:178157518 ZNF354A 0.68 7.49 0.42 1.02e-12 Neutrophil percentage of white cells; CESC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs6088590 1.000 rs6120708 chr20:33335526 G/A cg24642439 chr20:33292090 TP53INP2 0.83 11.6 0.58 2.04e-25 Coronary artery disease; CESC cis rs7223966 1.000 rs7220892 chr17:61908316 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.71 0.38 1.15e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.83 9.06 0.49 3.05e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2859741 0.546 rs2134846 chr1:37500723 G/A cg09363841 chr1:37513479 NA -0.52 -7.69 -0.43 2.85e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC trans rs9951602 0.512 rs4799247 chr18:76653449 G/A cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs2599510 0.744 rs2254106 chr2:32768797 G/A cg02381751 chr2:32503542 YIPF4 0.53 6.84 0.39 5.46e-11 Interleukin-18 levels; CESC cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg04455712 chr21:45112962 RRP1B 0.4 5.9 0.34 1.08e-8 Mean corpuscular volume; CESC cis rs933688 1.000 rs1895448 chr5:90743854 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.08 14.36 0.66 5.48e-35 Smoking behavior; CESC cis rs67311347 1.000 rs12630072 chr3:40517190 T/G cg09455208 chr3:40491958 NA 0.51 8.34 0.46 4.1e-15 Renal cell carcinoma; CESC cis rs10751667 0.643 rs7395592 chr11:934094 C/G cg06064525 chr11:970664 AP2A2 -0.54 -10.85 -0.55 5.96e-23 Alzheimer's disease (late onset); CESC cis rs947211 0.898 rs1772156 chr1:205752894 T/C cg26354017 chr1:205819088 PM20D1 0.43 5.42 0.32 1.31e-7 Parkinson's disease; CESC trans rs57221529 0.766 rs4957053 chr5:575927 T/C cg25482853 chr8:67687455 SGK3 1.01 10.17 0.53 9.74e-21 Lung disease severity in cystic fibrosis; CESC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.24 -0.63 4.54e-31 Developmental language disorder (linguistic errors); CESC cis rs11792861 0.926 rs7855282 chr9:111802614 T/A cg05043794 chr9:111880884 C9orf5 -0.4 -6.64 -0.38 1.8e-10 Menarche (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17952549 chr19:58983050 ZNF324 0.51 6.68 0.38 1.42e-10 Fibrinogen levels; CESC cis rs7264396 0.690 rs2425180 chr20:34447160 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.36 0.41 2.25e-12 Total cholesterol levels; CESC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg21770322 chr7:97807741 LMTK2 0.55 8.31 0.45 5.11e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg00750074 chr16:89608354 SPG7 -0.43 -6.27 -0.36 1.42e-9 Multiple myeloma (IgH translocation); CESC cis rs12477438 0.765 rs7605218 chr2:99593080 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.71 -0.47 3.43e-16 Chronic sinus infection; CESC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg22029157 chr1:209979665 IRF6 0.69 9.9 0.52 7.09e-20 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11808854 chr20:60697627 LSM14B 0.55 6.23 0.36 1.79e-9 Gut microbiome composition (summer); CESC trans rs11250098 0.503 rs7821826 chr8:10769439 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -6.07 -0.35 4.38e-9 Morning vs. evening chronotype; CESC cis rs2439831 0.867 rs2447208 chr15:43933895 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.78 8.32 0.46 4.72e-15 Lung cancer in ever smokers; CESC cis rs8072100 0.875 rs12451409 chr17:45544856 A/G cg25173405 chr17:45401733 C17orf57 -0.46 -6.03 -0.35 5.59e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs12048904 0.964 rs17123467 chr1:101331760 G/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.52 6.63 0.38 1.93e-10 Multiple sclerosis; CESC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg05332525 chr7:65337924 VKORC1L1 0.47 5.55 0.32 6.82e-8 Aortic root size; CESC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg07507251 chr3:52567010 NT5DC2 0.42 7.37 0.41 2.11e-12 Bipolar disorder; CESC cis rs2108622 0.785 rs3093199 chr19:15989871 T/A cg13772218 chr19:15982569 NA 0.31 6.07 0.35 4.34e-9 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs5758659 0.714 rs2284087 chr22:42485671 T/C cg00645731 chr22:42541494 CYP2D7P1 0.32 5.51 0.32 8.37e-8 Cognitive function; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27315239 chr1:53593711 SLC1A7 -0.47 -7.85 -0.43 1.01e-13 Gambling; CESC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg23985595 chr17:80112537 CCDC57 0.42 6.56 0.37 2.87e-10 Life satisfaction; CESC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg00074818 chr8:8560427 CLDN23 0.36 5.09 0.3 6.79e-7 Obesity-related traits; CESC cis rs1609391 0.543 rs9828009 chr3:136631275 C/T cg15507776 chr3:136538369 TMEM22 0.81 11.89 0.59 2.08e-26 Neuroticism; CESC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg06481639 chr22:41940642 POLR3H -0.63 -6.84 -0.39 5.31e-11 Vitiligo; CESC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 10.3 0.53 3.96e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.76 10.79 0.55 9.97e-23 Prudent dietary pattern; CESC cis rs7000551 0.751 rs2461482 chr8:22382898 C/T cg12081754 chr8:22256438 SLC39A14 0.46 6.21 0.36 2.06e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs11676348 0.818 rs7423433 chr2:218985084 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.03 -0.35 5.51e-9 Ulcerative colitis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg17524854 chr12:67663046 CAND1 -0.46 -6.12 -0.35 3.34e-9 Height; CESC cis rs4072980 0.524 rs16824514 chr1:38395947 A/T cg18451016 chr1:38461880 NA 0.42 5.93 0.34 9.41e-9 Coronary artery disease; CESC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg15664640 chr17:80829946 TBCD 0.41 5.98 0.34 7.36e-9 Breast cancer; CESC cis rs910316 1.000 rs12588240 chr14:75612083 C/A cg08847533 chr14:75593920 NEK9 1.02 19.83 0.77 2.88e-54 Height; CESC cis rs17764205 0.929 rs10420960 chr19:3256721 G/A cg04171554 chr19:2761892 SGTA -0.55 -5.15 -0.3 4.97e-7 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02780181 chr11:6704622 MRPL17 0.77 8.8 0.48 1.79e-16 Gut microbiome composition (summer); CESC cis rs7267979 0.816 rs422148 chr20:25512604 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.49 0.66 1.95e-35 Liver enzyme levels (alkaline phosphatase); CESC cis rs367615 0.660 rs4632850 chr5:108832883 C/G cg17395555 chr5:108820864 NA 0.64 11.03 0.56 1.56e-23 Colorectal cancer (SNP x SNP interaction); CESC cis rs6499129 1.000 rs7195790 chr16:67522289 A/G cg26727032 chr16:67993705 SLC12A4 -0.57 -5.78 -0.33 2.08e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7089973 0.872 rs35010779 chr10:116631816 A/C cg25233709 chr10:116636983 FAM160B1 0.34 5.03 0.3 9.07e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4780401 0.693 rs8191277 chr16:11764082 A/G cg01061890 chr16:11836724 TXNDC11 -0.39 -5.03 -0.3 9.21e-7 Rheumatoid arthritis; CESC cis rs7402982 0.625 rs4966009 chr15:99203496 C/T cg03437748 chr15:99193247 IGF1R 0.62 8.27 0.45 6.53e-15 Birth weight; CESC cis rs10838687 0.673 rs2290148 chr11:47346145 G/A cg25783544 chr11:47291846 MADD 0.57 6.53 0.37 3.43e-10 Proinsulin levels; CESC cis rs4523957 0.553 rs2641440 chr17:2027182 G/C cg16513277 chr17:2031491 SMG6 -0.76 -11.17 -0.57 5.37e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1808579 0.904 rs891387 chr18:21103909 A/G cg14672496 chr18:21087552 C18orf8 0.37 5.27 0.31 2.88e-7 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg13206674 chr6:150067644 NUP43 0.43 6.18 0.35 2.39e-9 Lung cancer; CESC cis rs10504229 0.520 rs55967509 chr8:57992448 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.06 -0.4 1.45e-11 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg22143856 chr6:28129313 ZNF389 0.53 6.73 0.38 1.06e-10 Depression; CESC cis rs832540 0.931 rs2662040 chr5:56246610 A/G cg24531977 chr5:56204891 C5orf35 0.41 5.12 0.3 5.87e-7 Coronary artery disease; CESC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.03 -0.3 8.96e-7 Breast cancer; CESC trans rs10463316 0.894 rs3846712 chr5:150759813 C/A cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.66e-9 Metabolite levels (Pyroglutamine); CESC cis rs910316 1.000 rs175442 chr14:75603564 T/C cg16144293 chr14:75469539 EIF2B2 0.4 5.26 0.31 3e-7 Height; CESC cis rs5498 0.809 rs1056538 chr19:10402938 G/A cg22910295 chr19:10403862 ICAM5 0.43 6.06 0.35 4.55e-9 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs2370759 1.000 rs2370759 chr10:32634972 G/A cg05361325 chr10:32636312 EPC1 -0.56 -5.21 -0.3 3.82e-7 Sexual dysfunction (female); CESC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg21963583 chr11:68658836 MRPL21 0.4 5.32 0.31 2.26e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3812565 0.506 rs4259518 chr9:139322503 T/C cg14019695 chr9:139328340 INPP5E 0.37 5.42 0.32 1.31e-7 Granulocyte percentage of myeloid white cells; CESC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20018561 chr13:52586135 ALG11;ATP7B 0.55 6.43 0.37 6e-10 Gut microbiome composition (summer); CESC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC trans rs2932538 0.744 rs6537742 chr1:113085197 G/T cg17706972 chr6:152126337 ESR1 0.39 6.04 0.35 5.08e-9 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs7605827 0.930 rs6431696 chr2:15540009 C/A cg19274914 chr2:15703543 NA 0.38 6.87 0.39 4.61e-11 Educational attainment (years of education); CESC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg05025164 chr4:1340916 KIAA1530 0.8 10.93 0.56 3.33e-23 Longevity; CESC cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg12756686 chr19:29218302 NA -0.49 -5.97 -0.34 7.41e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs1801251 1.000 rs13004406 chr2:233584557 A/T cg25237894 chr2:233734115 C2orf82 -0.49 -8.38 -0.46 3.1e-15 Coronary artery disease; CESC cis rs2933343 0.700 rs789238 chr3:128636715 A/G cg24203234 chr3:128598194 ACAD9 0.39 5.27 0.31 2.86e-7 IgG glycosylation; CESC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg18538332 chr22:24372958 LOC391322 0.76 9.27 0.49 6.62e-18 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg05283184 chr6:79620031 NA -0.41 -6.41 -0.37 6.48e-10 Intelligence (multi-trait analysis); CESC cis rs1707322 0.721 rs6699418 chr1:46100181 G/A cg06784218 chr1:46089804 CCDC17 0.41 7.31 0.41 3.1e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10089 1.000 rs883074 chr5:127445823 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.68 -9.16 -0.49 1.43e-17 Ileal carcinoids; CESC cis rs1062177 1.000 rs41494545 chr5:151235094 A/G cg00977110 chr5:151150581 G3BP1 -0.63 -7.01 -0.4 1.97e-11 Preschool internalizing problems; CESC cis rs8067354 0.645 rs9910518 chr17:57812067 T/C cg02344993 chr17:57696989 CLTC 0.68 8.07 0.44 2.5e-14 Hemoglobin concentration; CESC cis rs10883723 0.810 rs2296589 chr10:104248106 T/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.72 -0.33 2.86e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7296418 0.699 rs1109559 chr12:123757861 C/T cg05973401 chr12:123451056 ABCB9 0.47 6.2 0.36 2.13e-9 Platelet count; CESC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg14393609 chr7:65229607 NA 0.48 6.56 0.37 2.75e-10 Aortic root size; CESC cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg24130564 chr14:104152367 KLC1 -0.48 -6.36 -0.36 8.88e-10 Reticulocyte count; CESC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg07092213 chr7:1199455 ZFAND2A -0.5 -5.93 -0.34 9.31e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs35110281 0.807 rs2838328 chr21:45023234 G/C cg01579765 chr21:45077557 HSF2BP -0.58 -10.11 -0.53 1.53e-20 Mean corpuscular volume; CESC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg13770153 chr20:60521292 NA -0.45 -5.79 -0.33 2.03e-8 Body mass index; CESC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg27266027 chr21:40555129 PSMG1 0.46 5.57 0.32 6.36e-8 Cognitive function; CESC cis rs62103177 0.810 rs62103189 chr18:77627815 G/A cg12964065 chr18:77638022 KCNG2 0.58 5.46 0.32 1.07e-7 Opioid sensitivity; CESC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg03934478 chr11:495069 RNH1 0.53 5.13 0.3 5.68e-7 Body mass index; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg01510332 chr19:59087201 MGC2752 0.48 6.14 0.35 3.05e-9 Obesity-related traits; CESC cis rs3749237 0.595 rs4855859 chr3:49526300 C/T cg03060546 chr3:49711283 APEH 0.77 11.82 0.59 3.5e-26 Resting heart rate; CESC cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg14298792 chr15:30685198 CHRFAM7A -0.45 -5.32 -0.31 2.24e-7 Huntington's disease progression; CESC cis rs4555082 0.874 rs28625632 chr14:105748849 G/T cg27165867 chr14:105738592 BRF1 -0.48 -5.1 -0.3 6.44e-7 Mean platelet volume;Platelet distribution width; CESC cis rs1413885 0.516 rs7537733 chr1:65838229 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.46 6.08 0.35 4.16e-9 Anticoagulant levels; CESC trans rs2749592 0.550 rs10764135 chr10:37866845 C/T cg12057190 chr19:54976211 LENG9;CDC42EP5 -0.42 -6.0 -0.35 6.45e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7809950 1.000 rs2712201 chr7:107145564 T/C cg23024343 chr7:107201750 COG5 -0.43 -6.04 -0.35 5.25e-9 Coronary artery disease; CESC cis rs8013055 0.846 rs12893999 chr14:105970842 C/G cg23356831 chr14:105996513 TMEM121 0.37 5.11 0.3 6.19e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg26335602 chr6:28129616 ZNF389 0.37 5.41 0.32 1.38e-7 Cardiac Troponin-T levels; CESC cis rs1953600 1.000 rs1953600 chr10:81911725 A/G cg04850286 chr10:81895943 PLAC9 0.29 5.04 0.3 8.56e-7 Sarcoidosis; CESC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg15369054 chr17:80825471 TBCD 0.55 7.29 0.41 3.61e-12 Breast cancer; CESC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg21770322 chr7:97807741 LMTK2 0.54 7.92 0.44 6.73e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs12347191 0.500 rs925486 chr9:100619733 C/T cg13688889 chr9:100608707 NA -0.91 -13.42 -0.64 1.07e-31 Orofacial clefts; CESC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg04166393 chr7:2884313 GNA12 0.62 8.04 0.44 2.97e-14 Height; CESC cis rs9467711 0.606 rs9366655 chr6:26377385 C/G cg12826209 chr6:26865740 GUSBL1 0.63 5.62 0.33 4.82e-8 Autism spectrum disorder or schizophrenia; CESC cis rs853679 0.882 rs9380069 chr6:28203300 A/G cg26335602 chr6:28129616 ZNF389 0.56 5.8 0.34 1.86e-8 Depression; CESC cis rs11696501 0.694 rs2171371 chr20:44273482 T/C cg11783356 chr20:44313418 WFDC10B -0.33 -5.22 -0.31 3.57e-7 Brain structure; CESC cis rs12477438 0.520 rs4850897 chr2:99768419 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.85 0.62 1.02e-29 Chronic sinus infection; CESC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg14893161 chr1:205819251 PM20D1 0.39 5.19 0.3 4.12e-7 Parkinson's disease; CESC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.55 0.46 1.01e-15 Menopause (age at onset); CESC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg21782813 chr7:2030301 MAD1L1 0.51 7.25 0.41 4.52e-12 Bipolar disorder and schizophrenia; CESC cis rs2228479 0.764 rs35518096 chr16:89961140 C/A cg04013166 chr16:89971882 TCF25 0.7 7.2 0.4 6.05e-12 Skin colour saturation; CESC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.46 0.32 1.12e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7124681 0.584 rs12226590 chr11:47571808 T/C cg20307385 chr11:47447363 PSMC3 0.62 8.47 0.46 1.68e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22997124 chr22:24200000 SLC2A11 0.6 6.66 0.38 1.55e-10 Gut microbiome composition (summer); CESC cis rs9948 0.655 rs56913233 chr2:97405896 A/G cg01990225 chr2:97406019 LMAN2L -1.02 -7.77 -0.43 1.76e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs6701037 0.625 rs34270511 chr1:175128543 C/T cg00321850 chr1:175162397 KIAA0040 -0.43 -6.2 -0.36 2.1e-9 Alcohol dependence; CESC cis rs1267303 1.000 rs1267303 chr1:46990457 A/G cg25110126 chr1:46999211 NA 0.63 8.22 0.45 9.17e-15 Monobrow; CESC cis rs652260 0.967 rs667295 chr19:7901634 G/A cg26014689 chr19:7917955 EVI5L -0.44 -5.95 -0.34 8.63e-9 Menarche (age at onset); CESC cis rs7927771 0.524 rs10838782 chr11:47877800 A/G cg20307385 chr11:47447363 PSMC3 0.63 8.69 0.47 3.88e-16 Subjective well-being; CESC cis rs6502050 0.835 rs7209474 chr17:80136418 C/T cg23985595 chr17:80112537 CCDC57 -0.4 -6.33 -0.36 1.02e-9 Life satisfaction; CESC cis rs9916302 0.904 rs11867312 chr17:37597748 C/T cg00129232 chr17:37814104 STARD3 -0.56 -7.35 -0.41 2.4e-12 Glomerular filtration rate (creatinine); CESC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg18876405 chr7:65276391 NA -0.51 -7.01 -0.4 1.94e-11 Aortic root size; CESC cis rs10744422 0.925 rs2880678 chr12:123317099 C/T cg25930673 chr12:123319894 HIP1R -0.65 -5.28 -0.31 2.72e-7 Schizophrenia; CESC cis rs826838 0.967 rs1684413 chr12:39128704 G/A cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs9457247 0.765 rs12212247 chr6:167413539 T/C cg23791538 chr6:167370224 RNASET2 -0.55 -7.59 -0.42 5.41e-13 Crohn's disease; CESC cis rs2635047 0.811 rs10502880 chr18:44770746 T/C cg19077165 chr18:44547161 KATNAL2 -0.39 -5.19 -0.3 4.25e-7 Educational attainment; CESC cis rs2408955 0.522 rs11168408 chr12:48498327 G/A cg24011408 chr12:48396354 COL2A1 -0.52 -7.73 -0.43 2.24e-13 Glycated hemoglobin levels; CESC cis rs1878931 0.580 rs7204571 chr16:3402444 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.93 13.47 0.64 7.47e-32 Body mass index (adult); CESC cis rs6701037 1.000 rs6425323 chr1:175125036 C/T cg00321850 chr1:175162397 KIAA0040 -0.42 -5.88 -0.34 1.22e-8 Alcohol dependence; CESC trans rs6990917 0.590 rs6999075 chr8:68792070 A/G cg23652123 chr19:49303202 BCAT2 0.89 6.1 0.35 3.83e-9 Adverse response to lamotrigine and phenytoin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12498916 chr11:65265145 MALAT1 0.67 7.31 0.41 3.11e-12 Gut microbiome composition (summer); CESC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg11644478 chr21:40555479 PSMG1 -0.84 -12.62 -0.61 6.4e-29 Cognitive function; CESC cis rs6541297 1.000 rs2352723 chr1:230291868 C/T cg05784532 chr1:230284198 GALNT2 -0.48 -5.69 -0.33 3.38e-8 Coronary artery disease; CESC cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg00701064 chr4:6280414 WFS1 0.72 12.0 0.59 8.66e-27 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs10392 0.543 rs4812336 chr20:37547374 G/A cg27552599 chr20:37590471 DHX35 0.39 5.56 0.32 6.57e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg17372223 chr3:52568218 NT5DC2 0.53 8.47 0.46 1.77e-15 Electroencephalogram traits; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg07077115 chr13:28024429 MTIF3 -0.48 -6.39 -0.37 7.37e-10 Height; CESC trans rs1814175 0.817 rs7483795 chr11:49704930 G/A cg03929089 chr4:120376271 NA -0.92 -14.97 -0.68 4.04e-37 Height; CESC cis rs7546094 1.000 rs7546094 chr1:113154400 C/T cg22162597 chr1:113214053 CAPZA1 0.4 6.13 0.35 3.09e-9 Platelet distribution width; CESC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg04267008 chr7:1944627 MAD1L1 -0.53 -6.32 -0.36 1.08e-9 Bipolar disorder and schizophrenia; CESC cis rs950027 0.620 rs1145093 chr15:45649813 C/A cg21132104 chr15:45694354 SPATA5L1 0.66 8.52 0.46 1.22e-15 Response to fenofibrate (adiponectin levels); CESC cis rs3008870 1.000 rs2815370 chr1:67503727 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.0 -13.54 -0.64 4.16e-32 Lymphocyte percentage of white cells; CESC cis rs17376456 0.569 rs2045021 chr5:93224222 G/A cg25358565 chr5:93447407 FAM172A -0.7 -7.53 -0.42 8.2e-13 Diabetic retinopathy; CESC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg11987759 chr7:65425863 GUSB -0.48 -6.58 -0.37 2.54e-10 Aortic root size; CESC cis rs7089973 0.966 rs749649 chr10:116641999 G/A cg23260525 chr10:116636907 FAM160B1 0.34 5.32 0.31 2.2e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1620921 0.505 rs4708892 chr6:161209101 T/C cg01280913 chr6:161186852 NA -0.38 -5.66 -0.33 3.96e-8 Lipoprotein (a) - cholesterol levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03484612 chr15:75095495 CSK 0.45 6.44 0.37 5.7e-10 Fibrinogen levels; CESC cis rs9611565 0.559 rs9611619 chr22:41986714 C/T cg06481639 chr22:41940642 POLR3H -0.65 -6.38 -0.37 7.65e-10 Vitiligo; CESC trans rs61931739 0.500 rs7312938 chr12:34378708 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.35 0.54 2.55e-21 Morning vs. evening chronotype; CESC cis rs2652834 0.808 rs28583444 chr15:63357852 T/G cg05507819 chr15:63340323 TPM1 0.62 6.13 0.35 3.16e-9 HDL cholesterol; CESC cis rs8077577 0.945 rs11653988 chr17:18088833 C/T cg16794390 chr17:18148240 FLII 0.41 5.71 0.33 3.05e-8 Obesity-related traits; CESC cis rs1964356 0.967 rs2953802 chr8:8851881 G/A cg15556689 chr8:8085844 FLJ10661 0.41 5.4 0.31 1.5e-7 Mean corpuscular volume; CESC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg00684032 chr4:1343700 KIAA1530 0.39 5.43 0.32 1.27e-7 Obesity-related traits; CESC cis rs9420 0.961 rs11604325 chr11:57497011 C/A cg19752551 chr11:57585705 CTNND1 -0.36 -5.07 -0.3 7.55e-7 Schizophrenia; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg16216227 chr4:174293382 SAP30 -0.44 -6.33 -0.36 1.07e-9 Thyroid stimulating hormone; CESC cis rs854765 0.616 rs8076747 chr17:17853595 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 6.06 0.35 4.67e-9 Total body bone mineral density; CESC cis rs728616 0.614 rs61859198 chr10:82114628 C/A cg05935833 chr10:81318306 SFTPA2 -0.46 -5.8 -0.34 1.84e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9549367 0.789 rs7999579 chr13:113879357 T/C cg18105134 chr13:113819100 PROZ -0.66 -8.24 -0.45 8.04e-15 Platelet distribution width; CESC cis rs17253792 0.822 rs17253723 chr14:56154015 A/G cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs7666738 0.830 rs10005173 chr4:98816062 T/C cg17366294 chr4:99064904 C4orf37 0.54 7.47 0.42 1.14e-12 Colonoscopy-negative controls vs population controls; CESC cis rs2354432 0.556 rs1932979 chr1:146708912 A/G cg25205988 chr1:146714368 CHD1L -1.04 -8.53 -0.46 1.14e-15 Mitochondrial DNA levels; CESC cis rs1550582 0.548 rs7828645 chr8:135497385 A/G cg17885191 chr8:135476712 NA -0.88 -11.63 -0.58 1.52e-25 Educational attainment; CESC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg10691866 chr7:65817282 TPST1 0.33 5.53 0.32 7.81e-8 Aortic root size; CESC cis rs79057730 0.527 rs34519158 chr7:811114 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.87 7.34 0.41 2.59e-12 Initial pursuit acceleration; CESC trans rs12681287 0.547 rs7465511 chr8:87521481 C/T cg27317242 chr8:23145699 R3HCC1 -0.51 -6.08 -0.35 4.09e-9 Caudate activity during reward; CESC cis rs5771069 0.897 rs137858 chr22:50445601 T/C cg03721641 chr22:50451245 IL17REL 0.34 5.77 0.33 2.17e-8 Ulcerative colitis; CESC cis rs9326248 0.530 rs7114963 chr11:116875983 T/C cg01368799 chr11:117014884 PAFAH1B2 0.59 5.44 0.32 1.2e-7 Blood protein levels; CESC trans rs9325144 0.647 rs11168104 chr12:38857616 G/T cg10679878 chr6:156759499 NA -0.33 -6.0 -0.35 6.61e-9 Morning vs. evening chronotype; CESC cis rs9486719 1.000 rs2064947 chr6:97052754 C/T cg18709589 chr6:96969512 KIAA0776 -0.49 -5.49 -0.32 9.47e-8 Migraine;Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21789229 chr4:54232186 SCFD2 0.61 7.35 0.41 2.44e-12 Gut microbiome composition (summer); CESC cis rs453301 0.658 rs3855900 chr8:8901921 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -6.24 -0.36 1.77e-9 Joint mobility (Beighton score); CESC trans rs1814175 0.586 rs2866862 chr11:49954588 T/C cg03929089 chr4:120376271 NA -0.89 -14.87 -0.67 8.52e-37 Height; CESC cis rs1538970 0.847 rs781230 chr1:45880751 C/T cg24296786 chr1:45957014 TESK2 0.45 5.44 0.32 1.23e-7 Platelet count; CESC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg12963246 chr6:28129442 ZNF389 0.5 6.95 0.39 2.85e-11 Depression; CESC cis rs9560113 0.573 rs9560132 chr13:112237456 C/T cg10483660 chr13:112241077 NA 0.4 6.81 0.39 6.61e-11 Menarche (age at onset); CESC cis rs8072100 0.666 rs9913503 chr17:45776330 T/G cg08085267 chr17:45401833 C17orf57 -0.42 -5.31 -0.31 2.37e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs12713956 0.748 rs570877 chr2:21251040 A/C cg13097573 chr17:47957986 NA -0.82 -6.45 -0.37 5.32e-10 LDL cholesterol; CESC cis rs6546550 0.835 rs13002091 chr2:70118388 C/T cg02498382 chr2:70120550 SNRNP27 -0.42 -7.58 -0.42 6e-13 Prevalent atrial fibrillation; CESC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg17221315 chr6:27791827 HIST1H4J 0.47 5.83 0.34 1.6e-8 Parkinson's disease; CESC cis rs853679 0.824 rs34712084 chr6:28043828 A/G cg18032046 chr6:28092343 ZSCAN16 -0.75 -6.28 -0.36 1.36e-9 Depression; CESC cis rs4455778 0.536 rs38769 chr7:48940934 C/T cg26309511 chr7:48887640 NA 0.35 5.06 0.3 7.72e-7 Lung cancer in never smokers; CESC cis rs477692 0.692 rs7905095 chr10:131448143 C/T cg24747557 chr10:131355152 MGMT 0.38 5.25 0.31 3.06e-7 Response to temozolomide; CESC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs12410462 1.000 rs12407171 chr1:227642282 G/A cg04117972 chr1:227635322 NA 0.62 6.11 0.35 3.55e-9 Major depressive disorder; CESC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg13206674 chr6:150067644 NUP43 0.44 6.4 0.37 7e-10 Lung cancer; CESC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.14 0.4 9.06e-12 Bipolar disorder; CESC cis rs763121 0.853 rs5750633 chr22:38993467 A/G cg06022373 chr22:39101656 GTPBP1 0.94 17.17 0.73 5.98e-45 Menopause (age at onset); CESC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg02475777 chr4:1388615 CRIPAK 0.73 9.3 0.5 5.53e-18 Longevity; CESC cis rs1059312 1.000 rs12814773 chr12:129280786 C/T cg09035930 chr12:129282057 SLC15A4 0.79 11.27 0.57 2.42e-24 Systemic lupus erythematosus; CESC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg02951883 chr7:2050386 MAD1L1 -0.5 -6.84 -0.39 5.53e-11 Bipolar disorder and schizophrenia; CESC cis rs6815814 0.851 rs11736207 chr4:38766285 G/A cg02016764 chr4:38805732 TLR1 -0.68 -7.31 -0.41 3.06e-12 Breast cancer; CESC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg17143192 chr8:8559678 CLDN23 0.74 8.73 0.47 2.86e-16 Obesity-related traits; CESC cis rs11785400 0.793 rs4430070 chr8:143729184 G/C cg24634471 chr8:143751801 JRK 0.45 5.68 0.33 3.46e-8 Schizophrenia; CESC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg23172400 chr8:95962367 TP53INP1 0.39 7.9 0.44 7.65e-14 Type 2 diabetes; CESC cis rs8051149 0.688 rs12444533 chr16:87869711 C/T cg03408354 chr16:87871219 SLC7A5 -0.47 -5.77 -0.33 2.23e-8 Blood metabolite levels; CESC cis rs1355223 0.902 rs1258470 chr11:34729265 A/G cg11058730 chr11:34937778 PDHX;APIP 0.47 6.27 0.36 1.48e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7582720 1.000 rs72926786 chr2:203816494 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13323047 chr6:7261517 NA -0.61 -6.87 -0.39 4.63e-11 Gut microbiome composition (summer); CESC cis rs6963495 0.818 rs73190202 chr7:105166510 A/G cg13798780 chr7:105162888 PUS7 0.78 8.02 0.44 3.36e-14 Bipolar disorder (body mass index interaction); CESC cis rs3888647 0.622 rs4758618 chr11:2995186 A/T cg25174290 chr11:3078921 CARS 0.52 7.06 0.4 1.48e-11 Type 2 diabetes; CESC cis rs9911578 1.000 rs6503887 chr17:56993320 T/C cg12560992 chr17:57184187 TRIM37 0.93 15.26 0.68 3.55e-38 Intelligence (multi-trait analysis); CESC cis rs614226 1.000 rs7174 chr12:121017171 A/G cg01236616 chr12:121019343 POP5 1.49 18.26 0.75 8.44e-49 Type 1 diabetes nephropathy; CESC cis rs778371 0.915 rs748002 chr2:233757679 G/A cg08000102 chr2:233561755 GIGYF2 -0.81 -13.04 -0.63 2.34e-30 Schizophrenia; CESC cis rs818427 0.555 rs410701 chr5:112206416 G/A cg07820702 chr5:112228657 REEP5 0.41 5.51 0.32 8.44e-8 Total body bone mineral density; CESC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg11644478 chr21:40555479 PSMG1 -0.78 -11.54 -0.58 3.25e-25 Cognitive function; CESC cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg25427524 chr10:38739819 LOC399744 -0.65 -9.43 -0.5 2.21e-18 Extrinsic epigenetic age acceleration; CESC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.95 10.96 0.56 2.58e-23 Platelet count; CESC cis rs11249608 0.548 rs6867208 chr5:178455575 G/A cg01312482 chr5:178451176 ZNF879 -0.46 -6.42 -0.37 6.42e-10 Pubertal anthropometrics; CESC cis rs2731664 0.792 rs1130857 chr5:176863519 G/C cg23176889 chr5:176863531 GRK6 -0.63 -10.64 -0.55 2.94e-22 Intelligence (multi-trait analysis); CESC cis rs34172651 0.606 rs7194189 chr16:24703484 G/T cg06028605 chr16:24865363 SLC5A11 -0.45 -6.71 -0.38 1.16e-10 Intelligence (multi-trait analysis); CESC cis rs78456975 1.000 rs11883965 chr2:1560062 T/C cg26248373 chr2:1572462 NA -0.59 -5.7 -0.33 3.11e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.57 -6.92 -0.39 3.45e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs897080 0.552 rs1067369 chr2:44652654 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.87 0.34 1.28e-8 Height; CESC cis rs709400 0.663 rs8015918 chr14:103942991 A/G cg12935359 chr14:103987150 CKB -0.51 -7.44 -0.42 1.39e-12 Body mass index; CESC trans rs13035304 0.543 rs13017715 chr2:130500081 A/G cg18827756 chr15:42130735 JMJD7-PLA2G4B;PLA2G4B 0.37 6.1 0.35 3.71e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs3820068 0.705 rs16851731 chr1:15860240 A/G cg18192808 chr1:15853278 DNAJC16 0.49 6.0 0.35 6.43e-9 Systolic blood pressure; CESC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg03188948 chr7:1209495 NA 0.73 7.02 0.4 1.85e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1882538 0.538 rs7803848 chr7:133108547 C/T cg10665199 chr7:133106180 EXOC4 0.61 8.37 0.46 3.26e-15 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.27 0.31 2.78e-7 Colonoscopy-negative controls vs population controls; CESC cis rs13223928 0.666 rs9986825 chr7:3151177 C/T cg19214707 chr7:3157722 NA 0.4 5.69 0.33 3.43e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs2073300 0.609 rs6137941 chr20:23400848 G/A cg12062639 chr20:23401060 NAPB 1.07 8.23 0.45 8.58e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2549003 0.933 rs3846731 chr5:131814264 T/C cg21138405 chr5:131827807 IRF1 0.54 9.38 0.5 3.2e-18 Asthma (sex interaction); CESC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Parkinson's disease; CESC cis rs7542091 0.704 rs4133950 chr1:210044393 C/G cg09509183 chr1:209979624 IRF6 0.39 5.58 0.32 6.08e-8 Monobrow; CESC cis rs763121 0.853 rs2072794 chr22:39150543 G/T cg21395723 chr22:39101663 GTPBP1 0.45 5.65 0.33 4.18e-8 Menopause (age at onset); CESC cis rs8070128 0.637 rs4925133 chr17:17884801 A/G cg16928487 chr17:17741425 SREBF1 -0.46 -7.51 -0.42 8.88e-13 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13613210 chr9:99181598 ZNF367 0.53 6.37 0.36 8.42e-10 Gut microbiome composition (summer); CESC cis rs919433 0.929 rs7592511 chr2:198177974 A/G cg10820045 chr2:198174542 NA -0.44 -6.85 -0.39 5.28e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9837602 1.000 rs28714363 chr3:99752068 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 7.45 0.42 1.36e-12 Breast cancer; CESC cis rs11583043 1.000 rs17100939 chr1:101443701 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 5.51 0.32 8.64e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs3738443 0.672 rs6691539 chr1:247372672 C/T cg07706540 chr1:247373924 NA -0.43 -5.21 -0.3 3.8e-7 Alcohol dependence; CESC cis rs6426558 0.559 rs485234 chr1:227317747 A/G cg10327440 chr1:227177885 CDC42BPA 0.47 5.9 0.34 1.13e-8 Neutrophil percentage of white cells; CESC cis rs7589342 0.929 rs13024715 chr2:106433950 A/G cg16077055 chr2:106428750 NCK2 0.53 7.56 0.42 6.6e-13 Addiction; CESC cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg11952622 chr19:58962976 ZNF324B 0.46 6.14 0.35 3.08e-9 Uric acid clearance; CESC cis rs5769765 0.624 rs2285187 chr22:50185432 A/G cg02269571 chr22:50332266 NA -0.48 -6.12 -0.35 3.38e-9 Schizophrenia; CESC cis rs12142240 0.698 rs56063031 chr1:46825433 C/T cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Parkinson's disease; CESC cis rs1568889 0.838 rs6484359 chr11:28262328 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.6 0.64 2.62e-32 Bipolar disorder; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.1.448124R chr1:12054885 MFN2 -0.46 -6.12 -0.35 3.39e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2573652 0.723 rs2727201 chr15:100515311 A/G cg09918751 chr15:100517450 ADAMTS17 -0.45 -8.84 -0.48 1.38e-16 Height; CESC cis rs5758659 0.714 rs2413668 chr22:42505841 G/A cg04733989 chr22:42467013 NAGA -0.43 -6.05 -0.35 4.98e-9 Cognitive function; CESC cis rs12477438 0.520 rs8179690 chr2:99795300 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.82 -14.98 -0.68 3.63e-37 Chronic sinus infection; CESC cis rs919433 0.929 rs4850788 chr2:198182940 G/A cg03934865 chr2:198174659 NA -0.49 -7.67 -0.43 3.2e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12012699 chr18:46986876 DYM 0.45 6.23 0.36 1.82e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7246657 0.943 rs10415937 chr19:37830064 T/G cg24637308 chr11:6592297 DNHD1 0.53 6.17 0.35 2.55e-9 Coronary artery calcification; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07649988 chr10:102106576 SCD -0.46 -6.17 -0.35 2.48e-9 Fibrinogen levels; CESC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg04169830 chr2:88471460 THNSL2 0.33 5.13 0.3 5.63e-7 Response to metformin (IC50); CESC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg17911788 chr17:44343683 NA 0.43 6.62 0.38 1.97e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg11494091 chr17:61959527 GH2 0.76 13.39 0.64 1.42e-31 Prudent dietary pattern; CESC cis rs593982 0.920 rs10896044 chr11:65554680 C/G cg08755490 chr11:65554678 OVOL1 1.36 19.23 0.76 3.57e-52 Atopic dermatitis; CESC cis rs7219021 1.000 rs57185954 chr17:46844961 T/C cg16584676 chr17:46985605 UBE2Z -0.69 -7.64 -0.42 3.92e-13 Schizophrenia or bipolar disorder; CESC cis rs2130392 0.926 rs7677893 chr4:185625523 T/C cg21366198 chr4:185655624 MLF1IP -0.5 -6.95 -0.39 2.76e-11 Kawasaki disease; CESC cis rs4642101 0.765 rs3901665 chr3:12824610 C/A cg24848339 chr3:12840334 CAND2 0.38 5.89 0.34 1.18e-8 QRS complex (12-leadsum); CESC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg17372223 chr3:52568218 NT5DC2 0.44 6.36 0.36 8.64e-10 Bipolar disorder; CESC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs7927771 0.832 rs10838698 chr11:47385923 G/A cg20307385 chr11:47447363 PSMC3 0.57 6.65 0.38 1.71e-10 Subjective well-being; CESC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.35 0.81 6.51e-63 Prudent dietary pattern; CESC cis rs9303401 0.659 rs11079357 chr17:56902778 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.69 0.61 3.78e-29 Cognitive test performance; CESC cis rs34976449 1 rs34976449 chr1:8498326 T/TG cg00120948 chr1:8484417 RERE -0.4 -6.27 -0.36 1.48e-9 Lymphocyte counts; CESC cis rs3925075 1.000 rs55742763 chr16:31340368 G/A cg02846316 chr16:31340340 ITGAM 0.4 6.38 0.36 8.06e-10 IgA nephropathy; CESC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg03188948 chr7:1209495 NA 0.7 6.94 0.39 3.06e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg00166722 chr3:10149974 C3orf24 0.46 5.72 0.33 2.8e-8 Alzheimer's disease; CESC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg09699651 chr6:150184138 LRP11 0.4 5.2 0.3 4.03e-7 Lung cancer; CESC cis rs73019876 0.869 rs2522093 chr19:22125596 A/G cg11619707 chr19:22235551 ZNF257 -0.29 -5.22 -0.31 3.65e-7 Testicular germ cell tumor; CESC cis rs9858542 0.953 rs6766581 chr3:49539401 T/C cg03060546 chr3:49711283 APEH -0.54 -6.12 -0.35 3.44e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.64 7.85 0.43 1.05e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7267979 0.966 rs6037083 chr20:25290543 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.23 -0.75 1.11e-48 Liver enzyme levels (alkaline phosphatase); CESC trans rs4942242 0.640 rs17538959 chr13:44229911 T/G cg19169023 chr15:41853346 TYRO3 -0.65 -8.31 -0.45 5.16e-15 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1577917 0.652 rs75593931 chr6:86719539 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.37 -0.36 8.3e-10 Response to antipsychotic treatment; CESC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg02475777 chr4:1388615 CRIPAK 0.75 9.66 0.51 4.22e-19 Longevity; CESC cis rs2637266 0.783 rs4980006 chr10:78477993 G/C cg18941641 chr10:78392320 NA 0.44 8.37 0.46 3.26e-15 Pulmonary function; CESC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg00277769 chr7:97922759 BAIAP2L1 0.34 5.73 0.33 2.79e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg22968622 chr17:43663579 NA 1.36 18.55 0.75 8.09e-50 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2228479 0.850 rs11640336 chr16:89941153 T/C cg00800038 chr16:89945340 TCF25 -0.82 -7.14 -0.4 9e-12 Skin colour saturation; CESC cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg00825309 chr19:58991885 ZNF446 -0.57 -8.37 -0.46 3.38e-15 Uric acid clearance; CESC trans rs877282 0.853 rs12777155 chr10:754731 G/C cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs2014572 0.967 rs4801452 chr19:57768066 A/G cg24459738 chr19:57751996 ZNF805 -0.53 -7.55 -0.42 6.91e-13 Hyperactive-impulsive symptoms; CESC cis rs9287719 0.967 rs6759714 chr2:10747207 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg05263743 chr2:161263709 RBMS1 -0.54 -6.26 -0.36 1.51e-9 Gut microbiota (bacterial taxa); CESC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg18230493 chr5:56204884 C5orf35 -0.7 -8.29 -0.45 5.67e-15 Initial pursuit acceleration; CESC cis rs13118159 0.641 rs4974598 chr4:1313220 C/T cg02018176 chr4:1364513 KIAA1530 0.43 5.99 0.35 6.99e-9 Longevity; CESC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.76 9.03 0.49 3.54e-17 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22607980 chr1:89357197 GTF2B -0.6 -6.74 -0.38 9.88e-11 Gut microbiome composition (summer); CESC cis rs117623576 0.941 rs7070675 chr10:32407269 G/T cg03047570 chr10:32398778 NA -0.79 -6.88 -0.39 4.27e-11 Anti-saccade response; CESC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.71 0.33 2.98e-8 Bipolar disorder; CESC cis rs2228479 0.850 rs17226973 chr16:89825248 T/C cg00800038 chr16:89945340 TCF25 -0.92 -7.67 -0.43 3.37e-13 Skin colour saturation; CESC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg07701084 chr6:150067640 NUP43 0.46 6.45 0.37 5.26e-10 Lung cancer; CESC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs2235642 0.928 rs56289115 chr16:1608934 A/G cg03771183 chr16:1608904 IFT140 0.42 6.17 0.35 2.54e-9 Coronary artery disease; CESC cis rs7927592 0.956 rs7944870 chr11:68309108 C/G cg16797656 chr11:68205561 LRP5 0.38 5.33 0.31 2.06e-7 Total body bone mineral density; CESC cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1670533 0.615 rs59985183 chr4:1087171 G/T cg27284194 chr4:1044797 NA 0.47 6.2 0.36 2.1e-9 Recombination rate (females); CESC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 5.27 0.31 2.89e-7 Electroencephalogram traits; CESC cis rs7605827 0.930 rs879972 chr2:15703031 G/C cg19274914 chr2:15703543 NA 0.3 5.34 0.31 2.03e-7 Educational attainment (years of education); CESC cis rs4925386 1.000 rs1889201 chr20:60923075 C/T cg24112000 chr20:60950667 NA 0.5 7.21 0.4 5.92e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19143282 chr18:77507733 CTDP1 -0.66 -7.91 -0.44 7.09e-14 Gut microbiome composition (summer); CESC cis rs11250464 0.833 rs11250467 chr10:1409662 A/G cg26394196 chr10:1453818 ADARB2 -0.42 -5.66 -0.33 3.91e-8 Radiation response; CESC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg01988459 chr11:68622903 NA -0.43 -5.78 -0.33 2.13e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2439831 0.850 rs2228368 chr15:44102010 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.64 5.89 0.34 1.15e-8 Lung cancer in ever smokers; CESC trans rs208520 0.690 rs1738970 chr6:66809491 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.97 -12.82 -0.62 1.31e-29 Exhaled nitric oxide output; CESC cis rs11864453 0.793 rs7197453 chr16:72079127 G/C cg16558253 chr16:72132732 DHX38 -0.56 -8.26 -0.45 7.22e-15 Fibrinogen levels; CESC cis rs250677 0.652 rs250670 chr5:148446646 G/T cg18129178 chr5:148520854 ABLIM3 -0.51 -5.83 -0.34 1.58e-8 Breast cancer; CESC cis rs6964587 0.692 rs4729025 chr7:91847504 C/T cg17063962 chr7:91808500 NA 0.46 6.56 0.37 2.8e-10 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11884792 chr2:192542902 OBFC2A -0.6 -6.73 -0.38 1.06e-10 Gut microbiome composition (summer); CESC cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.44 5.72 0.33 2.8e-8 Personality dimensions; CESC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg14893161 chr1:205819251 PM20D1 0.84 13.8 0.65 5.19e-33 Menarche (age at onset); CESC cis rs1008375 0.900 rs3822235 chr4:17694916 C/T cg16339924 chr4:17578868 LAP3 -0.54 -6.7 -0.38 1.21e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22850304 chr1:39325639 RRAGC -0.48 -6.38 -0.36 8.04e-10 Fibrinogen levels; CESC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg07211511 chr3:129823064 LOC729375 -0.6 -7.32 -0.41 3e-12 Blood pressure (smoking interaction); CESC cis rs6456156 0.711 rs1855025 chr6:167537594 A/G cg07741184 chr6:167504864 NA -0.31 -5.27 -0.31 2.87e-7 Primary biliary cholangitis; CESC cis rs6460942 0.591 rs62448727 chr7:12332362 G/C cg06484146 chr7:12443880 VWDE -0.66 -7.27 -0.41 4.01e-12 Coronary artery disease; CESC cis rs1577917 1.000 rs12216328 chr6:86703418 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -5.97 -0.34 7.47e-9 Response to antipsychotic treatment; CESC trans rs8017423 1.000 rs8011810 chr14:90685669 A/G cg01911440 chr17:78818045 RPTOR -0.4 -6.05 -0.35 4.95e-9 Mortality in heart failure; CESC cis rs7927771 0.965 rs11039416 chr11:47846711 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -6.04 -0.35 5.24e-9 Subjective well-being; CESC cis rs3126085 0.877 rs4845742 chr1:152183949 G/A cg26876637 chr1:152193138 HRNR 0.48 5.44 0.32 1.21e-7 Atopic dermatitis; CESC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Parkinson's disease; CESC cis rs1707322 1.000 rs6671754 chr1:46433990 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9858542 0.543 rs2230929 chr3:49343175 G/A cg00383909 chr3:49044727 WDR6 0.57 5.28 0.31 2.75e-7 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6772849 0.896 rs61112519 chr3:128338176 T/A cg16766828 chr3:128327626 NA -0.31 -5.13 -0.3 5.67e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs863345 0.967 rs10489835 chr1:158521392 G/A cg12129480 chr1:158549410 OR10X1 -0.32 -6.39 -0.37 7.54e-10 Pneumococcal bacteremia; CESC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg06876107 chr14:102771053 RAGE 0.51 6.0 0.35 6.35e-9 Psoriatic arthritis; CESC trans rs7824557 0.507 rs7010590 chr8:11062882 C/T cg15556689 chr8:8085844 FLJ10661 0.59 7.64 0.42 3.94e-13 Retinal vascular caliber; CESC cis rs4589502 1.000 rs4589502 chr15:67155069 C/T cg09911534 chr15:67153556 NA -0.46 -5.16 -0.3 4.95e-7 Lung cancer (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07395075 chr16:56642428 MT2A -0.56 -6.53 -0.37 3.35e-10 Gut microbiome composition (summer); CESC cis rs7044106 0.762 rs10739570 chr9:123381222 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.8 12.37 0.6 4.9e-28 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs60154123 0.764 rs1418257 chr1:210452846 G/A cg21951975 chr1:209979733 IRF6 0.46 5.81 0.34 1.83e-8 Coronary artery disease; CESC cis rs1018836 0.663 rs2205152 chr8:91483618 C/T cg16814680 chr8:91681699 NA 0.55 7.37 0.41 2.16e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg18527119 chr7:66119851 NA 0.55 5.92 0.34 9.78e-9 Aortic root size; CESC cis rs10088262 0.629 rs6990565 chr8:124785645 C/A cg02993010 chr8:124780839 FAM91A1 -0.67 -8.34 -0.46 4.24e-15 Pancreatic cancer; CESC cis rs12042052 1.000 rs6669303 chr1:232912728 G/A cg06935979 chr1:232941706 KIAA1383 0.64 6.16 0.35 2.69e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs1729951 0.575 rs1682357 chr3:136692009 G/A cg04103450 chr3:136751342 NA 0.41 5.37 0.31 1.72e-7 Neuroticism; CESC cis rs1775715 0.737 rs55859032 chr10:32213239 C/T cg18675610 chr10:32216311 ARHGAP12 0.36 5.54 0.32 7.38e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs793571 0.502 rs421829 chr15:59079902 G/C cg05156742 chr15:59063176 FAM63B 0.78 11.21 0.57 3.83e-24 Schizophrenia; CESC cis rs427394 0.582 rs4701751 chr5:6704137 C/T cg10857441 chr5:6722123 POLS -0.43 -5.13 -0.3 5.64e-7 Menopause (age at onset); CESC cis rs10089 0.904 rs2195921 chr5:127489754 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 9.88 0.52 8.3e-20 Ileal carcinoids; CESC cis rs7078219 0.714 rs11190136 chr10:101287681 A/G cg09788492 chr10:101292477 NKX2-3 0.31 5.03 0.3 8.88e-7 Dental caries; CESC cis rs10744422 1.000 rs7959441 chr12:123363825 C/T cg22842854 chr12:123319900 HIP1R -0.61 -5.05 -0.3 8.19e-7 Schizophrenia; CESC cis rs4718428 0.576 rs12698546 chr7:66266906 G/T cg12165864 chr7:66369176 NA -0.58 -6.35 -0.36 9.1e-10 Corneal structure; CESC cis rs1580019 0.568 rs2122633 chr7:32523870 G/T cg06627557 chr7:32535165 LSM5;AVL9 1.02 16.56 0.71 9.36e-43 Cognitive ability; CESC trans rs208520 0.690 rs1580430 chr6:66715162 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 12.31 0.6 7.54e-28 Exhaled nitric oxide output; CESC cis rs1800795 0.901 rs2069833 chr7:22767664 C/T cg13104385 chr7:22767384 IL6 0.42 5.83 0.34 1.59e-8 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CESC trans rs9467711 0.745 rs9467714 chr6:26340785 C/T cg06606381 chr12:133084897 FBRSL1 -0.58 -6.28 -0.36 1.38e-9 Autism spectrum disorder or schizophrenia; CESC cis rs72781680 0.799 rs2551332 chr2:23988950 T/C cg08917208 chr2:24149416 ATAD2B 0.61 5.95 0.34 8.65e-9 Lymphocyte counts; CESC cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.05 -0.35 4.92e-9 Neuroticism; CESC cis rs1801251 0.964 rs13007783 chr2:233566679 G/A cg08000102 chr2:233561755 GIGYF2 0.66 9.02 0.48 3.78e-17 Coronary artery disease; CESC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg03351412 chr1:154909251 PMVK 0.7 9.52 0.5 1.11e-18 Prostate cancer; CESC cis rs6121246 0.609 rs2377317 chr20:30402502 A/G cg13852791 chr20:30311386 BCL2L1 -0.82 -10.54 -0.54 6.41e-22 Mean corpuscular hemoglobin; CESC cis rs116095464 0.558 rs7731089 chr5:290422 A/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.41 0.32 1.38e-7 Breast cancer; CESC cis rs4595586 0.505 rs11613808 chr12:39390823 T/A cg13010199 chr12:38710504 ALG10B 0.45 5.67 0.33 3.75e-8 Morning vs. evening chronotype; CESC cis rs6546550 0.935 rs1056482 chr2:70108256 A/T cg02498382 chr2:70120550 SNRNP27 -0.35 -6.06 -0.35 4.62e-9 Prevalent atrial fibrillation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19823710 chr17:29233276 C17orf42 0.49 6.23 0.36 1.83e-9 Gut microbiota (bacterial taxa); CESC cis rs7937682 0.883 rs2212520 chr11:111462096 C/T cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15813951 chr18:268135 THOC1 0.58 6.46 0.37 5.07e-10 Gut microbiome composition (summer); CESC trans rs2727020 0.729 rs4315497 chr11:49214499 G/A cg03929089 chr4:120376271 NA 0.78 11.95 0.59 1.29e-26 Coronary artery disease; CESC cis rs2882667 0.822 rs13187096 chr5:138404088 C/A cg04439458 chr5:138467593 SIL1 -0.37 -5.89 -0.34 1.15e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6543140 0.964 rs4851578 chr2:103028951 T/G cg04239558 chr2:103089729 SLC9A4 0.45 5.76 0.33 2.28e-8 Blood protein levels; CESC cis rs67311347 1.000 rs897117 chr3:40437294 C/T cg09455208 chr3:40491958 NA -0.44 -7.62 -0.42 4.63e-13 Renal cell carcinoma; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19711839 chr3:127842684 RUVBL1 -0.48 -6.19 -0.36 2.29e-9 Ulcerative colitis; CESC cis rs4764124 0.652 rs6488712 chr12:14939332 G/A cg19759883 chr12:14956454 WBP11;C12orf60 0.54 7.85 0.43 1e-13 Pubertal anthropometrics; CESC cis rs854765 0.547 rs7209003 chr17:17907393 T/A cg04398451 chr17:18023971 MYO15A -0.69 -10.33 -0.54 3.02e-21 Total body bone mineral density; CESC cis rs1670533 1.000 rs6858612 chr4:1053353 C/T cg04106633 chr4:1044584 NA 0.39 5.1 0.3 6.39e-7 Recombination rate (females); CESC cis rs1448094 0.802 rs11117146 chr12:86382870 C/T cg02569458 chr12:86230093 RASSF9 -0.37 -5.45 -0.32 1.14e-7 Major depressive disorder; CESC cis rs6828523 0.698 rs56004315 chr4:175859382 C/T cg14561282 chr4:175839468 ADAM29 0.44 5.11 0.3 6.21e-7 Breast cancer; CESC cis rs3925075 0.833 rs11641202 chr16:31330161 A/G cg02846316 chr16:31340340 ITGAM 0.38 6.07 0.35 4.41e-9 IgA nephropathy; CESC cis rs559928 0.606 rs11605856 chr11:63925528 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.92 0.34 9.68e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs6580649 0.941 rs1018973 chr12:48441692 C/G cg05342945 chr12:48394962 COL2A1 -0.51 -5.9 -0.34 1.09e-8 Lung cancer; CESC cis rs4803468 0.935 rs12602 chr19:41889748 T/C cg14132834 chr19:41945861 ATP5SL -0.67 -8.2 -0.45 1.02e-14 Height; CESC cis rs11690935 0.959 rs10803863 chr2:172535337 T/C cg13550731 chr2:172543902 DYNC1I2 0.94 14.64 0.67 5.97e-36 Schizophrenia; CESC cis rs55788414 0.932 rs9940186 chr16:81182199 A/T cg06400318 chr16:81190750 PKD1L2 -0.6 -7.01 -0.4 1.96e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs6120849 0.754 rs3818253 chr20:33596876 C/T cg06115741 chr20:33292138 TP53INP2 0.53 5.11 0.3 6.15e-7 Protein C levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25377475 chr1:236030556 LYST -0.4 -6.43 -0.37 5.95e-10 Gambling; CESC cis rs8114671 0.562 rs3746450 chr20:33508588 G/T cg06115741 chr20:33292138 TP53INP2 0.46 5.58 0.32 6.06e-8 Height; CESC cis rs7927771 0.524 rs1563820 chr11:47833398 A/T cg20307385 chr11:47447363 PSMC3 -0.58 -8.03 -0.44 3.12e-14 Subjective well-being; CESC cis rs7918232 0.891 rs10443987 chr10:27375377 A/T cg14240646 chr10:27532245 ACBD5 -0.67 -6.24 -0.36 1.75e-9 Breast cancer; CESC cis rs7246657 0.943 rs3803895 chr19:37898669 A/G cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.88e-9 Coronary artery calcification; CESC cis rs6800768 0.633 rs60706278 chr3:24101424 T/A cg10674438 chr3:24145617 LOC152024 -0.41 -5.55 -0.32 6.85e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.52 0.37 3.63e-10 Prudent dietary pattern; CESC cis rs2302729 0.545 rs10161275 chr12:2771018 A/G cg19945202 chr12:2788847 CACNA1C -0.46 -6.84 -0.39 5.6e-11 Sleep quality; CESC cis rs926938 0.527 rs360584 chr1:115463181 G/A cg12756093 chr1:115239321 AMPD1 0.45 6.28 0.36 1.41e-9 Autism; CESC cis rs10979 0.965 rs9390111 chr6:143894272 T/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs7520050 0.933 rs6656022 chr1:46394315 A/G cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.64e-8 Red blood cell count;Reticulocyte count; CESC cis rs9303401 0.659 rs62083436 chr17:57031742 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.6 0.61 7.67e-29 Cognitive test performance; CESC cis rs2235544 0.565 rs637590 chr1:54461703 A/G cg25741118 chr1:54482237 LDLRAD1 0.22 5.49 0.32 9.64e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg01988459 chr11:68622903 NA -0.45 -5.92 -0.34 9.72e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg09365446 chr1:150670422 GOLPH3L 0.42 6.02 0.35 5.67e-9 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12833168 chr14:39856160 NA -0.64 -7.74 -0.43 2.08e-13 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg06420487 chr17:61919686 SMARCD2 0.45 5.36 0.31 1.82e-7 Height; CESC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg24733560 chr20:60626293 TAF4 0.37 5.37 0.31 1.69e-7 Body mass index; CESC cis rs796364 0.951 rs72932280 chr2:200996851 G/C cg23649088 chr2:200775458 C2orf69 -0.53 -5.18 -0.3 4.34e-7 Schizophrenia; CESC cis rs1413885 0.516 rs11208637 chr1:65836553 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.46 5.91 0.34 1.03e-8 Anticoagulant levels; CESC cis rs2070997 0.591 rs4065994 chr9:133666116 G/C cg11464064 chr9:133710261 ABL1 0.49 5.59 0.32 5.67e-8 Response to amphetamines; CESC cis rs2180341 0.960 rs7766802 chr6:127709871 T/G cg27446573 chr6:127587934 RNF146 1.04 14.59 0.67 8.45e-36 Breast cancer; CESC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg03709012 chr19:19516395 GATAD2A 1.01 16.06 0.7 5.36e-41 Tonsillectomy; CESC cis rs611744 0.647 rs689275 chr8:109241822 T/C cg21045802 chr8:109455806 TTC35 0.46 5.7 0.33 3.25e-8 Dupuytren's disease; CESC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs6732160 0.588 rs13407363 chr2:73372558 T/C cg01422370 chr2:73384389 NA 0.53 8.49 0.46 1.51e-15 Intelligence (multi-trait analysis); CESC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg24675658 chr1:53192096 ZYG11B -0.62 -7.79 -0.43 1.5e-13 Monocyte count; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg06814102 chr11:64880135 TM7SF2 -0.44 -7.02 -0.4 1.88e-11 Vertical cup-disc ratio; CESC cis rs9790314 0.936 rs466399 chr3:161091194 G/T cg04691961 chr3:161091175 C3orf57 -0.39 -5.09 -0.3 6.91e-7 Morning vs. evening chronotype; CESC cis rs7916697 0.947 rs4745950 chr10:69996455 A/G cg06988349 chr10:69991859 ATOH7 -0.38 -6.28 -0.36 1.34e-9 Optic disc area; CESC cis rs12134245 0.747 rs11164929 chr1:92012836 G/C cg02896835 chr1:92012615 NA -0.57 -7.87 -0.44 9.32e-14 Breast cancer; CESC cis rs2235642 0.928 rs2076435 chr16:1607574 C/T cg09080909 chr16:1797204 MAPK8IP3 -0.37 -5.2 -0.3 4.07e-7 Coronary artery disease; CESC cis rs1355223 0.902 rs7121272 chr11:34752562 T/G cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.24 -0.36 1.75e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs782590 0.729 rs706548 chr2:55850106 C/G cg18811423 chr2:55921094 PNPT1 0.63 8.79 0.48 1.88e-16 Metabolic syndrome; CESC cis rs6519955 0.765 rs7292527 chr22:46423125 G/T cg05468064 chr22:46423449 NA -0.46 -7.89 -0.44 7.89e-14 Dupuytren's disease; CESC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg10691866 chr7:65817282 TPST1 0.33 5.47 0.32 1.02e-7 Aortic root size; CESC cis rs7617480 0.648 rs10865953 chr3:48759562 C/T cg06212747 chr3:49208901 KLHDC8B 0.45 5.08 0.3 7.18e-7 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs11792861 0.926 rs58795279 chr9:111851902 A/T cg13535736 chr9:111863775 C9orf5 -0.51 -6.74 -0.38 9.82e-11 Menarche (age at onset); CESC cis rs7917772 0.503 rs1536308 chr10:104288777 T/G cg22532475 chr10:104410764 TRIM8 -0.35 -5.97 -0.34 7.47e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9640161 0.789 rs36035506 chr7:150057843 C/T cg17279839 chr7:150038598 RARRES2 0.46 5.51 0.32 8.38e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg21782813 chr7:2030301 MAD1L1 0.37 5.06 0.3 7.96e-7 Bipolar disorder and schizophrenia; CESC cis rs854765 0.547 rs8069811 chr17:17922280 G/A cg16928487 chr17:17741425 SREBF1 -0.57 -10.14 -0.53 1.24e-20 Total body bone mineral density; CESC cis rs3617 0.573 rs56383738 chr3:52908398 T/C cg07507251 chr3:52567010 NT5DC2 -0.32 -5.24 -0.31 3.21e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg11752832 chr7:134001865 SLC35B4 0.57 7.47 0.42 1.2e-12 Mean platelet volume; CESC cis rs17376456 0.542 rs10070350 chr5:93103753 C/G cg21475434 chr5:93447410 FAM172A 0.49 5.04 0.3 8.6e-7 Diabetic retinopathy; CESC cis rs1729951 0.546 rs361246 chr3:136695667 G/A cg15507776 chr3:136538369 TMEM22 0.41 5.16 0.3 4.86e-7 Neuroticism; CESC cis rs9905704 0.846 rs304298 chr17:56839689 G/A cg12560992 chr17:57184187 TRIM37 0.62 7.8 0.43 1.45e-13 Testicular germ cell tumor; CESC trans rs3942852 0.774 rs11039519 chr11:48130094 G/C cg03929089 chr4:120376271 NA -0.56 -6.34 -0.36 1.01e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs929354 0.707 rs1182445 chr7:157024428 C/G cg05182265 chr7:156933206 UBE3C 0.51 7.52 0.42 8.71e-13 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14528254 chr7:5862839 ZNF815 -0.43 -6.01 -0.35 6e-9 Fibrinogen levels; CESC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.98 0.34 7.35e-9 Tonsillectomy; CESC cis rs6448317 0.954 rs11946846 chr4:24922703 G/A cg21108841 chr4:24914750 CCDC149 -0.56 -6.71 -0.38 1.2e-10 Heschl's gyrus morphology; CESC cis rs11792861 0.855 rs116127510 chr9:111868344 G/A cg13535736 chr9:111863775 C9orf5 -0.5 -6.66 -0.38 1.6e-10 Menarche (age at onset); CESC cis rs34779708 0.931 rs13376871 chr10:35369056 A/G cg04310649 chr10:35416472 CREM -0.52 -6.39 -0.37 7.31e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs17253792 0.822 rs75995456 chr14:56073194 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs4888262 0.526 rs8062959 chr16:74627628 T/C cg01733217 chr16:74700730 RFWD3 0.86 11.88 0.59 2.16e-26 Testicular germ cell tumor; CESC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.99 -17.24 -0.73 3.53e-45 Prudent dietary pattern; CESC cis rs1008375 1.000 rs56308330 chr4:17643050 G/A cg02297831 chr4:17616191 MED28 0.53 6.64 0.38 1.76e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs763121 0.853 rs2281019 chr22:39064378 T/A cg06544989 chr22:39130855 UNC84B 0.48 8.4 0.46 2.69e-15 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18124955 chr2:173292329 ITGA6 0.56 6.04 0.35 5.1e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21869951 chr1:43824422 CDC20 0.59 6.78 0.38 7.81e-11 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs17233448 chr16:89816424 G/T cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs9911578 1.000 rs4372750 chr17:57013803 A/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.17 -0.3 4.61e-7 Intelligence (multi-trait analysis); CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg05564831 chr3:52568323 NT5DC2 0.52 8.82 0.48 1.62e-16 Electroencephalogram traits; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04904834 chr1:179851103 TOR1AIP1 -0.52 -6.85 -0.39 5.27e-11 Height; CESC cis rs9329289 0.510 rs1155447 chr10:2553240 C/T cg15501526 chr10:2543763 NA 0.47 7.57 0.42 6.16e-13 Age-related hearing impairment; CESC cis rs60843830 1.000 rs60484953 chr2:221560 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.88 11.52 0.58 3.63e-25 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs12586317 0.547 rs77780729 chr14:35496176 C/A cg16230307 chr14:35515116 FAM177A1 1.11 11.71 0.58 8.54e-26 Psoriasis; CESC trans rs61931739 1.000 rs12311881 chr12:34036100 A/G cg26384229 chr12:38710491 ALG10B -0.46 -6.19 -0.36 2.28e-9 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25371538 chr10:6186663 PFKFB3 -0.45 -6.08 -0.35 4.06e-9 Fibrinogen levels; CESC cis rs2760061 0.583 rs1745413 chr1:228212456 A/G cg02753203 chr1:228287806 NA 0.8 11.37 0.57 1.2e-24 Diastolic blood pressure; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07664667 chr16:778351 HAGHL -0.52 -6.7 -0.38 1.25e-10 Ulcerative colitis; CESC cis rs12602172 1 rs12602172 chr17:38163567 G/A cg17467752 chr17:38218738 THRA 0.69 10.55 0.54 5.78e-22 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs2130392 0.926 rs10428357 chr4:185636217 T/A cg21366198 chr4:185655624 MLF1IP -0.5 -7.02 -0.4 1.81e-11 Kawasaki disease; CESC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg25036284 chr2:26402008 FAM59B -0.74 -8.4 -0.46 2.72e-15 Gut microbiome composition (summer); CESC cis rs858239 0.509 rs57611130 chr7:23184552 C/A cg23682824 chr7:23144976 KLHL7 0.49 6.33 0.36 1.04e-9 Cerebrospinal fluid biomarker levels; CESC cis rs7937682 0.632 rs10789850 chr11:111750829 C/T cg09085632 chr11:111637200 PPP2R1B 0.86 10.98 0.56 2.39e-23 Primary sclerosing cholangitis; CESC cis rs9486719 1.000 rs12208011 chr6:96991105 G/A cg06623918 chr6:96969491 KIAA0776 -0.79 -8.2 -0.45 1.07e-14 Migraine;Coronary artery disease; CESC cis rs9858542 0.953 rs9818590 chr3:49525096 A/G cg03060546 chr3:49711283 APEH -0.55 -6.28 -0.36 1.34e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs17401966 0.931 rs34225619 chr1:10371987 C/T cg15208524 chr1:10270712 KIF1B 0.45 5.54 0.32 7.26e-8 Hepatocellular carcinoma; CESC cis rs2882667 1.000 rs10064201 chr5:138309405 C/T cg04439458 chr5:138467593 SIL1 -0.35 -5.59 -0.32 5.75e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg00031303 chr3:195681400 NA 0.46 5.81 0.34 1.74e-8 Pancreatic cancer; CESC cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg15017067 chr4:17643749 FAM184B 0.39 5.46 0.32 1.09e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7937682 0.575 rs34695265 chr11:111719128 T/C cg22437258 chr11:111473054 SIK2 -0.48 -5.38 -0.31 1.66e-7 Primary sclerosing cholangitis; CESC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg07507251 chr3:52567010 NT5DC2 0.35 5.89 0.34 1.18e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs6460942 0.597 rs4719315 chr7:12528634 A/G cg20607287 chr7:12443886 VWDE -0.71 -7.7 -0.43 2.69e-13 Coronary artery disease; CESC cis rs9649465 0.967 rs12531955 chr7:123377066 G/A cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.46e-7 Migraine; CESC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg11764359 chr7:65958608 NA 0.79 11.32 0.57 1.67e-24 Aortic root size; CESC cis rs2075371 0.501 rs1643051 chr7:134025372 A/G cg20476274 chr7:133979776 SLC35B4 -0.44 -5.58 -0.32 6.07e-8 Mean platelet volume; CESC cis rs7772486 0.875 rs9322046 chr6:146393625 A/G cg23711669 chr6:146136114 FBXO30 0.79 11.78 0.59 4.98e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs17253792 0.822 rs28392709 chr14:56093685 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg11764359 chr7:65958608 NA -0.89 -13.96 -0.65 1.37e-33 Aortic root size; CESC cis rs9649465 1.000 rs10215473 chr7:123380681 C/G cg04330084 chr7:123175371 IQUB -0.38 -5.12 -0.3 5.79e-7 Migraine; CESC cis rs12971120 1.000 rs12971120 chr18:72174023 A/G cg26446133 chr18:72167187 CNDP2 -0.75 -9.76 -0.51 2.08e-19 Refractive error; CESC cis rs34779708 0.931 rs12248333 chr10:35362977 A/G cg03585969 chr10:35415529 CREM 0.75 9.56 0.51 8.47e-19 Inflammatory bowel disease;Crohn's disease; CESC trans rs1814175 0.645 rs847639 chr11:49919603 C/T cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs7224737 1.000 rs9889640 chr17:40293497 C/T cg20291162 chr17:40259547 DHX58 -0.4 -5.48 -0.32 9.96e-8 Fibrinogen levels; CESC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg11764359 chr7:65958608 NA -0.54 -7.05 -0.4 1.59e-11 Aortic root size; CESC cis rs2415984 0.622 rs8022305 chr14:46946545 C/T cg14871534 chr14:47121158 RPL10L -0.36 -5.37 -0.31 1.69e-7 Number of children ever born; CESC cis rs477692 1.000 rs503660 chr10:131418999 A/G cg05714579 chr10:131428358 MGMT 0.47 6.31 0.36 1.18e-9 Response to temozolomide; CESC cis rs7605827 0.930 rs2049719 chr2:15515058 A/G cg19274914 chr2:15703543 NA 0.32 5.55 0.32 6.84e-8 Educational attainment (years of education); CESC cis rs9303401 0.659 rs3809724 chr17:57061238 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.0 11.29 0.57 2.2e-24 Cognitive test performance; CESC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg22535103 chr8:58192502 C8orf71 -0.67 -7.19 -0.4 6.53e-12 Developmental language disorder (linguistic errors); CESC cis rs2380220 0.576 rs4498363 chr6:96042338 A/C cg15832292 chr6:96025679 MANEA 0.74 7.8 0.43 1.41e-13 Behavioural disinhibition (generation interaction); CESC cis rs2732480 0.538 rs1387260 chr12:48703091 A/C cg24011408 chr12:48396354 COL2A1 0.43 5.91 0.34 1.07e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg10691866 chr7:65817282 TPST1 -0.36 -6.03 -0.35 5.48e-9 Aortic root size; CESC cis rs4481887 0.927 rs4427440 chr1:248480337 T/A cg00666640 chr1:248458726 OR2T12 0.36 5.98 0.34 7.16e-9 Common traits (Other); CESC cis rs7107174 1.000 rs1385601 chr11:77936064 A/C cg02023728 chr11:77925099 USP35 0.41 5.89 0.34 1.17e-8 Testicular germ cell tumor; CESC cis rs1707322 1.000 rs1707322 chr1:46505147 C/T cg05343316 chr1:45956843 TESK2 0.43 5.32 0.31 2.23e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1691799 0.863 rs1168291 chr12:66732488 T/C cg16791601 chr12:66731901 HELB -0.75 -12.95 -0.62 4.83e-30 White blood cell count (basophil); CESC cis rs6439153 0.933 rs34193129 chr3:128691407 G/A cg25356066 chr3:128598488 ACAD9 0.53 6.9 0.39 3.76e-11 Pneumococcal bacteremia; CESC cis rs796364 0.901 rs13030683 chr2:201061535 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.56 5.51 0.32 8.54e-8 Schizophrenia; CESC cis rs12912251 0.948 rs34141940 chr15:38989657 G/A cg01338139 chr15:38987640 C15orf53 -0.46 -5.27 -0.31 2.89e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg18350739 chr11:68623251 NA -0.46 -7.02 -0.4 1.88e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs12540874 0.670 rs3887826 chr7:50544961 G/A cg18232548 chr7:50535776 DDC -0.44 -6.13 -0.35 3.24e-9 Systemic sclerosis; CESC cis rs2635047 0.615 rs2576052 chr18:44690107 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -5.07 -0.3 7.57e-7 Educational attainment; CESC cis rs13006833 0.668 rs2582736 chr2:191144892 A/T cg25963032 chr2:191064776 C2orf88 0.37 5.05 0.3 8.21e-7 Urinary metabolites; CESC cis rs34779708 0.966 rs7077242 chr10:35481965 A/C cg04310649 chr10:35416472 CREM 0.54 6.55 0.37 3.05e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs240764 0.736 rs9968897 chr6:100945858 G/A cg21058520 chr6:100914733 NA 0.36 5.68 0.33 3.48e-8 Neuroticism; CESC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg27170947 chr2:26402098 FAM59B -0.59 -7.07 -0.4 1.36e-11 Gut microbiome composition (summer); CESC cis rs4148883 0.504 rs9307238 chr4:100136182 A/G cg12011299 chr4:100065546 ADH4 -0.5 -7.07 -0.4 1.36e-11 Alcohol dependence; CESC cis rs9818758 0.607 rs9862483 chr3:49195441 G/A cg00383909 chr3:49044727 WDR6 0.85 6.44 0.37 5.54e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs1670533 0.872 rs10017931 chr4:1060747 G/A cg27284194 chr4:1044797 NA 0.49 6.28 0.36 1.37e-9 Recombination rate (females); CESC cis rs2274273 0.837 rs6573017 chr14:55802243 G/A cg04306507 chr14:55594613 LGALS3 0.32 6.38 0.36 7.9e-10 Protein biomarker; CESC cis rs1348850 0.645 rs13431091 chr2:178434615 A/G cg23306229 chr2:178417860 TTC30B 0.85 9.38 0.5 3.05e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7044106 0.708 rs10984992 chr9:123473416 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.0 0.62 3.26e-30 Hip circumference adjusted for BMI; CESC cis rs72945132 0.823 rs12292240 chr11:70152612 T/C cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs2777491 0.574 rs11858812 chr15:41731550 G/A cg18705301 chr15:41695430 NDUFAF1 -1.06 -16.94 -0.72 3.99e-44 Ulcerative colitis; CESC cis rs472402 0.580 rs11738248 chr5:6657494 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.55 -7.07 -0.4 1.41e-11 Response to amphetamines; CESC cis rs6570726 0.935 rs419854 chr6:145844085 A/C cg05347473 chr6:146136440 FBXO30 0.48 6.54 0.37 3.18e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10411936 0.626 rs8109817 chr19:16587889 T/C cg10248733 chr19:16607483 C19orf44;CALR3 0.55 6.62 0.38 2.03e-10 White blood cell count;Multiple sclerosis; CESC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.61 0.38 2.15e-10 Prudent dietary pattern; CESC trans rs637571 0.524 rs674363 chr11:65699134 G/A cg17712092 chr4:129076599 LARP1B -0.64 -8.24 -0.45 7.94e-15 Eosinophil percentage of white cells; CESC cis rs4253772 0.550 rs9615913 chr22:46668515 A/T cg09491104 chr22:46646882 C22orf40 0.54 8.1 0.45 2.06e-14 LDL cholesterol;Cholesterol, total; CESC cis rs6088590 1.000 rs6120705 chr20:33313740 T/C cg08999081 chr20:33150536 PIGU 0.58 8.95 0.48 6.2e-17 Coronary artery disease; CESC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg09177884 chr7:1199841 ZFAND2A -0.51 -6.37 -0.36 8.23e-10 Longevity;Endometriosis; CESC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg11247378 chr22:39784982 NA 0.57 8.18 0.45 1.22e-14 Intelligence (multi-trait analysis); CESC cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg02551604 chr5:131831745 NA -0.37 -5.27 -0.31 2.81e-7 Asthma (sex interaction); CESC cis rs75804782 0.521 rs56387296 chr2:239426298 A/G cg18131467 chr2:239335373 ASB1 -0.71 -5.45 -0.32 1.16e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs9443645 0.869 rs7762022 chr6:79502859 C/A cg05283184 chr6:79620031 NA -0.43 -6.75 -0.38 9.12e-11 Intelligence (multi-trait analysis); CESC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 6.01 0.35 6.21e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs67478160 0.643 rs2223937 chr14:104286380 A/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.66 0.55 2.59e-22 Schizophrenia; CESC cis rs35955747 0.870 rs5997986 chr22:31834939 C/T cg25791279 chr22:32026902 PISD -0.44 -5.3 -0.31 2.44e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg07952391 chr2:88470173 THNSL2 -0.48 -6.94 -0.39 2.99e-11 Response to metformin (IC50); CESC cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg07636037 chr3:49044803 WDR6 1.05 19.43 0.77 6.66e-53 Parkinson's disease; CESC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg17372223 chr3:52568218 NT5DC2 0.42 6.47 0.37 4.6e-10 Bipolar disorder; CESC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg25072359 chr17:41440525 NA 0.45 5.96 0.34 7.83e-9 Menopause (age at onset); CESC cis rs7666738 0.830 rs4441757 chr4:98927059 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4889855 0.530 rs4890048 chr17:78549602 G/A cg16591659 chr17:78472290 NA 0.31 5.22 0.31 3.6e-7 Fractional excretion of uric acid; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02370978 chr2:86333167 PTCD3;POLR1A -0.41 -6.22 -0.36 1.89e-9 Gambling; CESC cis rs9324022 0.929 rs72698721 chr14:101181189 G/A cg18089426 chr14:101175970 NA 0.57 7.01 0.4 1.92e-11 Plateletcrit; CESC cis rs2404602 0.669 rs17367297 chr15:77158026 A/C cg26408565 chr15:76604113 ETFA -0.39 -5.68 -0.33 3.6e-8 Blood metabolite levels; CESC trans rs7615952 0.599 rs67575510 chr3:125742355 C/G cg07211511 chr3:129823064 LOC729375 -0.59 -6.62 -0.38 2e-10 Blood pressure (smoking interaction); CESC cis rs208520 0.507 rs3903670 chr6:66812183 T/C cg07460842 chr6:66804631 NA -1.11 -27.23 -0.86 9.42e-79 Exhaled nitric oxide output; CESC cis rs7100689 0.577 rs7901663 chr10:82153488 C/G cg00277334 chr10:82204260 NA -0.46 -6.3 -0.36 1.24e-9 Post bronchodilator FEV1; CESC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.37 -0.31 1.76e-7 Life satisfaction; CESC trans rs17808461 1.000 rs16592 chr17:31373094 C/T cg01914314 chr5:157117640 NA -0.51 -6.22 -0.36 1.98e-9 Obesity-related traits; CESC cis rs2733201 1.000 rs2412849 chr15:44276555 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.63 -5.57 -0.32 6.31e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs7940866 0.838 rs10736592 chr11:130800572 C/T cg14779329 chr11:130786720 SNX19 0.33 5.08 0.3 6.99e-7 Schizophrenia; CESC cis rs9486719 1.000 rs12190508 chr6:96898269 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.21e-15 Migraine;Coronary artery disease; CESC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg13395646 chr4:1353034 KIAA1530 -0.42 -5.76 -0.33 2.38e-8 Longevity; CESC cis rs2242073 0.660 rs6710715 chr2:209002681 A/G cg10392614 chr2:208977121 NA -0.37 -5.04 -0.3 8.79e-7 Attention deficit hyperactivity disorder; CESC cis rs9929218 1.000 rs13330350 chr16:68800849 C/T cg02972257 chr16:68554789 NA 0.43 5.22 0.31 3.65e-7 Colorectal cancer; CESC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg17724175 chr1:150552817 MCL1 0.4 5.99 0.35 6.69e-9 Melanoma; CESC cis rs12618769 0.625 rs3769733 chr2:99100716 A/G cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs904092 0.720 rs1229976 chr4:100202078 C/T cg12011299 chr4:100065546 ADH4 -0.56 -6.34 -0.36 9.78e-10 Alcohol dependence; CESC cis rs2549003 0.966 rs10065633 chr5:131816716 T/C cg02551604 chr5:131831745 NA -0.37 -5.22 -0.31 3.53e-7 Asthma (sex interaction); CESC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg18769074 chr3:133464867 TF 0.33 6.02 0.35 5.71e-9 Iron status biomarkers; CESC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg11890956 chr21:40555474 PSMG1 -1.11 -21.17 -0.79 6.49e-59 Cognitive function; CESC cis rs11055008 0.620 rs12816452 chr12:12833006 A/T cg04607235 chr12:12878440 APOLD1 -0.49 -6.53 -0.37 3.41e-10 Pulse pressure; CESC cis rs2204008 0.729 rs114133083 chr12:38182923 G/C cg26384229 chr12:38710491 ALG10B -0.43 -5.88 -0.34 1.22e-8 Bladder cancer; CESC cis rs701145 0.556 rs355762 chr3:154012614 G/A cg16511985 chr3:153974050 SGEF 0.43 5.89 0.34 1.14e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03556369 chr5:172721020 NA -0.57 -6.52 -0.37 3.52e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.625 rs2050027 chr6:146116113 C/G cg23711669 chr6:146136114 FBXO30 -0.91 -13.64 -0.64 1.86e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs3749237 0.595 rs4855861 chr3:49525962 G/T cg06212747 chr3:49208901 KLHDC8B 0.49 6.55 0.37 3.02e-10 Resting heart rate; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09863028 chr2:242076577 PASK -0.48 -6.31 -0.36 1.17e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs77741769 0.571 rs4766979 chr12:121281748 G/A cg02419362 chr12:121203948 SPPL3 0.34 5.59 0.32 5.6e-8 Mean corpuscular volume; CESC cis rs673253 0.638 rs552638 chr1:44043392 G/A cg19743044 chr1:44115203 KDM4A 0.41 5.13 0.3 5.74e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.22e-15 Colonoscopy-negative controls vs population controls; CESC cis rs11785400 0.793 rs9297972 chr8:143723660 C/T cg24634471 chr8:143751801 JRK 0.45 5.8 0.34 1.84e-8 Schizophrenia; CESC cis rs9916302 0.660 rs665413 chr17:37455678 T/A cg07936489 chr17:37558343 FBXL20 0.89 9.69 0.51 3.32e-19 Glomerular filtration rate (creatinine); CESC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg09263875 chr16:632152 PIGQ 0.69 11.78 0.59 4.76e-26 Height; CESC cis rs9291683 0.525 rs12506455 chr4:10031569 T/A cg02734326 chr4:10020555 SLC2A9 0.49 6.88 0.39 4.19e-11 Bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11608447 chr9:38620746 ANKRD18A;C9orf122 -0.41 -6.36 -0.36 9.05e-10 Fibrinogen levels; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg06110578 chr6:43597079 MAD2L1BP;GTPBP2 0.69 7.04 0.4 1.62e-11 Diastolic blood pressure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11050527 chr8:54755511 ATP6V1H 0.5 6.6 0.38 2.17e-10 Gut microbiota (bacterial taxa); CESC cis rs35160687 0.545 rs1863050 chr2:86558376 G/A cg01119172 chr2:86362222 SNORD94;PTCD3 -0.43 -5.73 -0.33 2.77e-8 Night sleep phenotypes; CESC cis rs1355223 0.902 rs11607035 chr11:34718911 G/A cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.07 -0.35 4.41e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs13095912 1.000 rs2034344 chr3:185337788 T/C cg04313601 chr11:10315759 SBF2 0.47 6.0 0.35 6.5e-9 Systolic blood pressure; CESC cis rs2797160 0.967 rs1777182 chr6:126013614 T/A cg05901451 chr6:126070800 HEY2 0.46 6.48 0.37 4.42e-10 Endometrial cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22520562 chr4:82392859 RASGEF1B 0.55 6.13 0.35 3.22e-9 Gut microbiome composition (summer); CESC cis rs1018836 0.773 rs7837109 chr8:91639178 C/T cg16814680 chr8:91681699 NA -0.77 -11.86 -0.59 2.53e-26 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2425143 0.818 rs2378414 chr20:34534374 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -6.96 -0.39 2.72e-11 Blood protein levels; CESC cis rs2635047 0.601 rs2576058 chr18:44641397 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.56 0.32 6.58e-8 Educational attainment; CESC cis rs9362426 0.708 rs4707367 chr6:88101188 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -5.61 -0.33 4.99e-8 Depressive episodes in bipolar disorder; CESC cis rs2243480 1.000 rs7456042 chr7:65299778 T/C cg12463550 chr7:65579703 CRCP 0.68 5.62 0.33 4.83e-8 Diabetic kidney disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15851312 chr15:73076263 ADPGK 0.43 6.09 0.35 3.9e-9 Systemic lupus erythematosus; CESC cis rs3747547 1.000 rs17418324 chr9:37921712 G/A cg13774184 chr9:37916125 SHB -0.72 -6.06 -0.35 4.75e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs1957429 0.614 rs380741 chr14:65322027 C/T cg23373153 chr14:65346875 NA -0.75 -5.88 -0.34 1.26e-8 Pediatric areal bone mineral density (radius); CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 6.01 0.35 5.97e-9 Electroencephalogram traits; CESC cis rs897984 0.684 rs6950 chr16:30995669 T/C cg00531865 chr16:30841666 NA 0.51 7.02 0.4 1.84e-11 Dementia with Lewy bodies; CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg15147215 chr3:52552868 STAB1 -0.31 -5.54 -0.32 7.15e-8 Bipolar disorder; CESC cis rs3749237 0.557 rs7631908 chr3:49425707 T/G cg07636037 chr3:49044803 WDR6 0.62 8.97 0.48 5.41e-17 Resting heart rate; CESC cis rs9911578 1.000 rs9904879 chr17:56864422 G/A cg12560992 chr17:57184187 TRIM37 0.92 15.58 0.69 2.71e-39 Intelligence (multi-trait analysis); CESC cis rs7833986 0.501 rs2976044 chr8:56986737 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.91 0.39 3.64e-11 Height; CESC cis rs8070128 0.637 rs4925133 chr17:17884801 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.53 6.98 0.39 2.4e-11 Total body bone mineral density; CESC cis rs9543976 0.800 rs4885318 chr13:76151537 G/A cg01531495 chr13:76123901 UCHL3 0.55 5.48 0.32 9.76e-8 Diabetic retinopathy; CESC cis rs35520189 0.591 rs34027384 chr2:113698094 G/A cg06156847 chr2:113672199 IL1F7 0.38 5.38 0.31 1.6e-7 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs1018836 0.545 rs4236827 chr8:91688943 A/T cg16814680 chr8:91681699 NA -0.99 -17.68 -0.74 9.37e-47 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs709400 0.520 rs28583452 chr14:103938664 C/A cg12935359 chr14:103987150 CKB -0.51 -7.44 -0.42 1.39e-12 Body mass index; CESC cis rs921968 0.541 rs647990 chr2:219441428 T/C cg02176678 chr2:219576539 TTLL4 0.5 8.86 0.48 1.18e-16 Mean corpuscular hemoglobin concentration; CESC cis rs11583043 0.874 rs11578366 chr1:101396852 T/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 5.17 0.3 4.71e-7 Ulcerative colitis;Inflammatory bowel disease; CESC trans rs1223629 1.000 rs1223630 chr10:95906215 T/C cg21019522 chr11:2920789 SLC22A18;SLC22A18AS -0.72 -6.02 -0.35 5.71e-9 Glucose homeostasis traits; CESC cis rs7772486 0.875 rs13198450 chr6:146370524 C/A cg23711669 chr6:146136114 FBXO30 0.85 12.56 0.61 1.02e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7927771 0.524 rs7107922 chr11:47669289 C/A cg20307385 chr11:47447363 PSMC3 0.62 8.74 0.47 2.81e-16 Subjective well-being; CESC cis rs1878931 0.535 rs7188903 chr16:3412861 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.73 9.09 0.49 2.36e-17 Body mass index (adult); CESC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg24675658 chr1:53192096 ZYG11B 0.53 6.69 0.38 1.29e-10 Monocyte count; CESC cis rs7923609 1.000 rs7073746 chr10:64904071 A/G cg01631684 chr10:65280961 REEP3 -0.45 -5.48 -0.32 9.94e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7809950 0.678 rs2395869 chr7:106940098 C/A cg23024343 chr7:107201750 COG5 -0.49 -6.26 -0.36 1.56e-9 Coronary artery disease; CESC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Urate levels; CESC cis rs7432375 0.610 rs7621932 chr3:136517016 C/T cg15507776 chr3:136538369 TMEM22 0.6 8.0 0.44 3.8e-14 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs2637266 0.935 rs1866890 chr10:78397073 C/T cg18941641 chr10:78392320 NA 0.45 8.6 0.47 7.12e-16 Pulmonary function; CESC cis rs16966142 1.000 rs3890534 chr16:89835289 A/G cg27121462 chr16:89883253 FANCA -0.62 -5.28 -0.31 2.65e-7 Caffeine consumption; CESC cis rs820218 0.962 rs707707 chr17:73669521 C/T cg01592526 chr17:73663357 RECQL5;SAP30BP 0.43 5.55 0.32 7.06e-8 Rotator cuff tears; CESC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg11859384 chr17:80120422 CCDC57 0.4 5.5 0.32 8.88e-8 Life satisfaction; CESC cis rs7692995 1.000 rs6449353 chr4:18033488 T/C cg08925142 chr4:18023851 LCORL -0.44 -5.08 -0.3 7.08e-7 Height; CESC cis rs9581857 0.725 rs117947621 chr13:28022267 T/C cg01674679 chr13:27998804 GTF3A -0.68 -5.35 -0.31 1.87e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs4481887 0.861 rs10788776 chr1:248479177 T/C cg00666640 chr1:248458726 OR2T12 0.34 5.76 0.33 2.35e-8 Common traits (Other); CESC cis rs8005677 0.962 rs34917191 chr14:23387628 T/C cg25600027 chr14:23388339 RBM23 -0.43 -5.33 -0.31 2.08e-7 Cognitive ability (multi-trait analysis); CESC cis rs225245 0.610 rs321608 chr17:33880636 A/G cg05299278 chr17:33885742 SLFN14 0.38 5.2 0.3 3.9e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs2204008 0.522 rs12370263 chr12:38113311 A/G cg13010199 chr12:38710504 ALG10B 0.47 5.65 0.33 4.15e-8 Bladder cancer; CESC cis rs3796619 0.924 rs4690209 chr4:1077575 G/A cg27284194 chr4:1044797 NA 0.36 5.5 0.32 9.08e-8 Recombination rate (males); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26421181 chr17:73937284 FBF1 0.56 6.11 0.35 3.6e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22340067 chr1:11967826 NA -0.53 -6.05 -0.35 4.92e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16285215 chr12:31477228 FAM60A;FLJ13224 0.51 6.55 0.37 2.91e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs55823223 0.680 rs57287238 chr17:73850940 T/C cg06969265 chr17:73775802 H3F3B 0.63 6.83 0.39 5.7e-11 Psoriasis; CESC cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg04287289 chr16:89883240 FANCA -0.59 -7.86 -0.43 9.69e-14 Vitiligo; CESC trans rs17780086 0.529 rs7406406 chr17:30220153 T/G cg20587970 chr11:113659929 NA -0.61 -8.13 -0.45 1.7e-14 Height; CESC cis rs2806561 0.929 rs6669568 chr1:23540469 G/A cg12483005 chr1:23474871 LUZP1 -0.33 -5.33 -0.31 2.07e-7 Height; CESC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg27266060 chr8:22091797 NA 0.38 7.85 0.43 1.04e-13 Hypertriglyceridemia; CESC cis rs1153858 1.000 rs67831559 chr15:45649307 G/T cg14582100 chr15:45693742 SPATA5L1 0.43 6.13 0.35 3.12e-9 Homoarginine levels; CESC cis rs3091242 0.809 rs660129 chr1:25727438 C/T cg27572855 chr1:25598939 RHD 0.43 7.08 0.4 1.32e-11 Erythrocyte sedimentation rate; CESC cis rs4481887 0.893 rs10158180 chr1:248481423 C/T cg00666640 chr1:248458726 OR2T12 0.36 5.98 0.34 7.16e-9 Common traits (Other); CESC cis rs1023500 0.505 rs134891 chr22:42675882 T/C cg05082376 chr22:42548792 NA -0.36 -5.4 -0.32 1.46e-7 Schizophrenia; CESC trans rs8073060 0.586 rs7213804 chr17:34010931 T/G cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7615952 0.932 rs9841157 chr3:125635655 C/A cg05084668 chr3:125655381 ALG1L -0.49 -5.52 -0.32 8e-8 Blood pressure (smoking interaction); CESC cis rs941408 0.515 rs1640262 chr19:2779134 C/T cg06609049 chr19:2785107 THOP1 -0.85 -13.19 -0.63 6.79e-31 Total cholesterol levels; CESC cis rs921968 0.643 rs535830 chr2:219372233 C/G cg02176678 chr2:219576539 TTLL4 0.39 6.75 0.38 9.18e-11 Mean corpuscular hemoglobin concentration; CESC cis rs644799 0.540 rs10831419 chr11:95478037 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.41 5.16 0.3 4.78e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs684232 0.623 rs365118 chr17:580543 G/A cg15660573 chr17:549704 VPS53 -0.84 -12.4 -0.61 3.84e-28 Prostate cancer; CESC cis rs870825 0.860 rs10015194 chr4:185598925 C/T cg04058563 chr4:185651563 MLF1IP 0.6 6.11 0.35 3.53e-9 Blood protein levels; CESC cis rs1355223 0.902 rs1258464 chr11:34731496 C/T cg11058730 chr11:34937778 PDHX;APIP -0.5 -6.84 -0.39 5.55e-11 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs425277 1.000 rs12401379 chr1:2058580 G/C cg04315214 chr1:2043799 PRKCZ -0.43 -6.01 -0.35 6.02e-9 Height; CESC cis rs9649213 0.533 rs62478235 chr7:98030349 G/C cg09267113 chr7:98030324 BAIAP2L1 -0.45 -5.92 -0.34 9.68e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg22903471 chr2:27725779 GCKR -0.51 -7.18 -0.4 7.11e-12 Total body bone mineral density; CESC cis rs6963495 0.818 rs73192125 chr7:105175068 A/C cg19920283 chr7:105172520 RINT1 0.76 7.82 0.43 1.25e-13 Bipolar disorder (body mass index interaction); CESC cis rs3204270 0.639 rs6565620 chr17:79658100 C/T cg26965718 chr17:79658957 HGS -0.73 -5.52 -0.32 8.05e-8 Dental caries; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg03762994 chr17:6899332 ALOX12 -0.33 -5.45 -0.32 1.17e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21629349 chr11:60691880 TMEM132A 0.61 7.43 0.42 1.53e-12 Gut microbiome composition (summer); CESC cis rs3733585 0.638 rs6414766 chr4:9956474 G/A cg11266682 chr4:10021025 SLC2A9 -0.59 -11.13 -0.56 7.46e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg23048001 chr7:2026167 MAD1L1 0.48 6.07 0.35 4.45e-9 Bipolar disorder and schizophrenia; CESC cis rs11098499 0.569 rs55845118 chr4:120290913 T/C cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs72781680 0.898 rs72780121 chr2:23995918 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg00339695 chr16:24857497 SLC5A11 -0.5 -6.57 -0.37 2.58e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs748404 0.723 rs560134 chr15:43555699 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.98 0.44 4.38e-14 Lung cancer; CESC cis rs6499255 0.951 rs7198242 chr16:69648495 C/T cg15192750 chr16:69999425 NA -0.49 -5.75 -0.33 2.45e-8 IgE levels; CESC cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg11752832 chr7:134001865 SLC35B4 0.53 6.82 0.39 6.3e-11 Mean platelet volume; CESC cis rs12477438 0.520 rs11695751 chr2:99708247 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.09 0.7 4.08e-41 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02466711 chr8:102218365 ZNF706 0.63 7.2 0.4 6.33e-12 Gut microbiome composition (summer); CESC cis rs9868809 0.881 rs34368826 chr3:48670827 G/T cg07636037 chr3:49044803 WDR6 -0.63 -5.15 -0.3 5.14e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs4835473 0.722 rs7662277 chr4:144920638 A/T cg25736465 chr4:144833511 NA -0.46 -6.94 -0.39 2.96e-11 Immature fraction of reticulocytes; CESC cis rs9858542 0.953 rs6766581 chr3:49539401 T/C cg07274523 chr3:49395745 GPX1 0.66 8.05 0.44 2.78e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4689388 0.926 rs6446480 chr4:6295565 C/T cg14416269 chr4:6271139 WFS1 0.44 7.35 0.41 2.47e-12 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -1.05 -17.17 -0.73 6.45e-45 Height; CESC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.69 -7.57 -0.42 6.33e-13 Gut microbiome composition (summer); CESC cis rs7089973 0.872 rs11818115 chr10:116634891 G/A cg25233709 chr10:116636983 FAM160B1 0.34 5.03 0.3 9.07e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg06873352 chr17:61820015 STRADA 0.72 12.8 0.62 1.61e-29 Prudent dietary pattern; CESC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg18402987 chr7:1209562 NA 0.64 6.63 0.38 1.93e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg04287289 chr16:89883240 FANCA -0.56 -7.6 -0.42 4.97e-13 Vitiligo; CESC cis rs8067354 0.645 rs2173119 chr17:57859705 C/T cg02344993 chr17:57696989 CLTC 0.57 6.21 0.36 2.03e-9 Hemoglobin concentration; CESC cis rs941873 0.869 rs7917610 chr10:81117237 T/C cg09469691 chr10:81107165 PPIF 0.56 7.56 0.42 6.79e-13 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19701658 chr3:160286309 NA -0.45 -6.25 -0.36 1.6e-9 Gut microbiome composition (summer); CESC cis rs11190604 1.000 rs7084810 chr10:102297546 A/G cg07080220 chr10:102295463 HIF1AN 0.7 6.5 0.37 3.99e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg27535305 chr1:53392650 SCP2 -0.31 -5.07 -0.3 7.62e-7 Monocyte count; CESC cis rs2191566 1.000 rs384544 chr19:44505255 A/T cg20607764 chr19:44506953 ZNF230 0.6 7.73 0.43 2.19e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs4642101 0.662 rs1969154 chr3:12829156 A/G cg05775895 chr3:12838266 CAND2 0.35 5.3 0.31 2.46e-7 QRS complex (12-leadsum); CESC trans rs11971186 0.793 rs412791 chr7:126494124 C/T cg10894441 chr11:111169905 C11orf92;C11orf93 -0.47 -6.07 -0.35 4.43e-9 Chemerin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20770540 chr3:123304003 PTPLB 0.56 6.1 0.35 3.78e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14024780 chr1:179262948 SOAT1 0.59 6.3 0.36 1.23e-9 Gut microbiome composition (summer); CESC cis rs2204008 0.775 rs12099736 chr12:38344111 C/G cg13010199 chr12:38710504 ALG10B 0.48 6.05 0.35 4.92e-9 Bladder cancer; CESC trans rs9650657 0.589 rs6985109 chr8:10761585 A/G cg15556689 chr8:8085844 FLJ10661 0.54 6.57 0.37 2.63e-10 Neuroticism; CESC cis rs921968 0.565 rs2037622 chr2:219609440 T/C cg02176678 chr2:219576539 TTLL4 -0.47 -8.3 -0.45 5.29e-15 Mean corpuscular hemoglobin concentration; CESC cis rs7937682 0.883 rs517982 chr11:111462687 T/C cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13932339 chr15:25684205 UBE3A -0.39 -6.25 -0.36 1.6e-9 Gambling; CESC cis rs73206853 0.764 rs56838584 chr12:110666136 A/G cg12870014 chr12:110450643 ANKRD13A 0.69 5.93 0.34 9.34e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs367615 0.680 rs77013 chr5:108963086 T/A cg17395555 chr5:108820864 NA 0.44 6.06 0.35 4.65e-9 Colorectal cancer (SNP x SNP interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06510563 chr19:11308259 KANK2 -0.41 -6.31 -0.36 1.16e-9 Gambling; CESC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg23803603 chr1:2058230 PRKCZ 0.33 5.76 0.33 2.38e-8 Height; CESC cis rs9303401 0.659 rs62083410 chr17:56964386 T/C cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.45 0.61 2.57e-28 Cognitive test performance; CESC trans rs1814175 0.645 rs11040703 chr11:50024961 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -18.54 -0.75 9.01e-50 Height; CESC cis rs8017423 0.967 rs7158180 chr14:90729117 C/T cg14092571 chr14:90743983 NA -0.56 -8.38 -0.46 3.07e-15 Mortality in heart failure; CESC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.64 0.47 5.23e-16 Menopause (age at onset); CESC cis rs9929218 0.551 rs8051095 chr16:68722049 G/A cg02972257 chr16:68554789 NA -0.42 -5.17 -0.3 4.63e-7 Colorectal cancer; CESC cis rs12477438 0.798 rs2123686 chr2:99690135 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs17666538 0.585 rs336444 chr8:633123 C/G cg02524346 chr8:600233 NA -0.74 -6.46 -0.37 5.11e-10 IgG glycosylation; CESC cis rs7665939 1.000 rs11942826 chr4:190109362 C/T cg14840187 chr4:190284988 NA -0.69 -6.9 -0.39 3.74e-11 Amyotrophic lateral sclerosis; CESC cis rs7772486 0.713 rs79248977 chr6:146319388 C/A cg05347473 chr6:146136440 FBXO30 0.5 6.47 0.37 4.8e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs13242816 0.881 rs35210394 chr7:116104911 C/G cg04696780 chr7:116139425 CAV2 -0.62 -5.69 -0.33 3.31e-8 P wave duration; CESC cis rs74181299 0.819 rs2252867 chr2:65296280 T/C cg05010058 chr2:65284262 CEP68 0.35 6.1 0.35 3.66e-9 Pulse pressure; CESC cis rs733592 0.507 rs3825403 chr12:48457159 G/A cg24011408 chr12:48396354 COL2A1 -0.5 -8.34 -0.46 4.03e-15 Plateletcrit; CESC cis rs7267979 0.789 rs9927 chr20:25277244 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.85 16.51 0.71 1.4e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs2439831 0.681 rs1549525 chr15:43627855 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.99 0.56 2.1e-23 Lung cancer in ever smokers; CESC cis rs10189230 0.868 rs1367242 chr2:222353441 A/G cg14652038 chr2:222343519 EPHA4 0.35 7.22 0.41 5.49e-12 Urate levels in lean individuals; CESC cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.78 8.84 0.48 1.4e-16 Alzheimer's disease; CESC cis rs763121 0.819 rs5750658 chr22:39060917 C/T cg06544989 chr22:39130855 UNC84B 0.49 8.49 0.46 1.53e-15 Menopause (age at onset); CESC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs2243480 0.803 rs55700941 chr7:65389800 T/A cg12463550 chr7:65579703 CRCP 0.73 5.61 0.33 5.07e-8 Diabetic kidney disease; CESC cis rs3780486 1.000 rs3780486 chr9:33139453 C/T cg13443165 chr9:33130375 B4GALT1 0.4 5.33 0.31 2.1e-7 IgG glycosylation; CESC cis rs9303401 1.000 rs6503882 chr17:56915761 T/C cg12560992 chr17:57184187 TRIM37 0.49 5.6 0.33 5.26e-8 Cognitive test performance; CESC cis rs7772486 0.875 rs13204280 chr6:146415368 T/C cg23711669 chr6:146136114 FBXO30 0.81 11.91 0.59 1.71e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs36051895 0.623 rs10283473 chr9:5244708 C/A cg02405213 chr9:5042618 JAK2 -0.56 -6.78 -0.38 7.92e-11 Pediatric autoimmune diseases; CESC cis rs4702 0.611 rs1894401 chr15:91429042 C/T cg05469396 chr15:91419421 FURIN 0.4 5.54 0.32 7.14e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6701037 0.566 rs13373754 chr1:175139275 C/A cg00321850 chr1:175162397 KIAA0040 0.46 6.45 0.37 5.37e-10 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09129563 chr1:179198950 ABL2 0.56 6.17 0.35 2.49e-9 Gut microbiome composition (summer); CESC cis rs2637266 1.000 rs2637268 chr10:78332213 G/T cg18941641 chr10:78392320 NA 0.41 7.47 0.42 1.14e-12 Pulmonary function; CESC cis rs7927771 0.832 rs896816 chr11:47394338 T/C cg05585544 chr11:47624801 NA 0.48 7.12 0.4 1.01e-11 Subjective well-being; CESC cis rs684232 0.602 rs331014 chr17:532103 C/T cg15660573 chr17:549704 VPS53 -0.81 -11.96 -0.59 1.19e-26 Prostate cancer; CESC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg18876405 chr7:65276391 NA 0.73 10.35 0.54 2.61e-21 Aortic root size; CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg19592336 chr6:28129416 ZNF389 0.63 8.37 0.46 3.45e-15 Depression; CESC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg09263875 chr16:632152 PIGQ 0.68 11.67 0.58 1.11e-25 Height; CESC cis rs9815354 0.812 rs17218103 chr3:41943724 A/G cg03022575 chr3:42003672 ULK4 0.71 6.45 0.37 5.42e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg18337363 chr3:52569053 NT5DC2 0.29 5.27 0.31 2.85e-7 Bipolar disorder; CESC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg04369109 chr6:150039330 LATS1 -0.4 -5.44 -0.32 1.21e-7 Lung cancer; CESC cis rs12681366 0.663 rs2919662 chr8:95470272 C/A cg13257157 chr8:95487014 RAD54B 0.39 5.34 0.31 2.04e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg16405210 chr4:1374714 KIAA1530 -0.58 -7.82 -0.43 1.29e-13 Longevity; CESC cis rs4523957 0.928 rs216201 chr17:2198800 C/T cg16513277 chr17:2031491 SMG6 0.62 8.52 0.46 1.23e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4523957 0.928 rs216204 chr17:2196659 G/A cg16513277 chr17:2031491 SMG6 0.59 8.08 0.44 2.29e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4704187 0.687 rs922390 chr5:74401269 A/G cg03227963 chr5:74354835 NA 0.32 5.94 0.34 8.7e-9 Response to amphetamines; CESC cis rs752010 0.905 rs2038977 chr1:42094659 A/G cg06885757 chr1:42089581 HIVEP3 0.54 9.01 0.48 4.17e-17 Lupus nephritis in systemic lupus erythematosus; CESC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg13880726 chr7:1868755 MAD1L1 0.51 6.78 0.38 8e-11 Bipolar disorder and schizophrenia; CESC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg23281280 chr6:28129359 ZNF389 0.6 8.0 0.44 3.86e-14 Depression; CESC cis rs11168351 0.517 rs10875754 chr12:48557922 G/C cg24011408 chr12:48396354 COL2A1 0.49 8.02 0.44 3.33e-14 Bipolar disorder and schizophrenia; CESC cis rs12477438 0.520 rs11883676 chr2:99800814 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.21 0.68 5.36e-38 Chronic sinus infection; CESC cis rs67311347 1.000 rs7628796 chr3:40507332 G/A cg01475735 chr3:40494733 NA 0.43 5.4 0.31 1.47e-7 Renal cell carcinoma; CESC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.39 -6.19 -0.36 2.26e-9 Cystic fibrosis severity; CESC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.79 8.12 0.45 1.81e-14 Platelet count; CESC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg27170947 chr2:26402098 FAM59B -0.87 -9.85 -0.52 1.01e-19 Gut microbiome composition (summer); CESC cis rs1801251 1.000 rs3816334 chr2:233708806 A/G cg25237894 chr2:233734115 C2orf82 -0.46 -8.06 -0.44 2.65e-14 Coronary artery disease; CESC cis rs2070488 1.000 rs2268758 chr3:38514049 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.94 17.13 0.72 8.71e-45 Electrocardiographic conduction measures; CESC cis rs1559088 0.803 rs10405770 chr19:33616549 C/T cg27124370 chr19:33622961 WDR88 0.43 5.59 0.32 5.74e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs2727020 0.521 rs7930855 chr11:49521660 C/T cg03929089 chr4:120376271 NA 0.69 7.89 0.44 8.11e-14 Coronary artery disease; CESC cis rs9768139 0.733 rs12698209 chr7:158117595 A/G cg06219351 chr7:158114137 PTPRN2 0.46 7.33 0.41 2.74e-12 Calcium levels; CESC cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg00255919 chr5:131827918 IRF1 0.51 8.84 0.48 1.4e-16 Asthma (sex interaction); CESC cis rs6788895 1.000 rs76801042 chr3:150482720 A/C cg09723797 chr3:150481914 SIAH2 0.73 5.55 0.32 6.95e-8 Breast cancer; CESC cis rs752010 0.645 rs1109254 chr1:42091770 T/C cg06885757 chr1:42089581 HIVEP3 0.72 11.4 0.57 9.16e-25 Lupus nephritis in systemic lupus erythematosus; CESC cis rs965469 1.000 rs6037553 chr20:3313884 A/G cg25506879 chr20:3388711 C20orf194 -0.59 -6.26 -0.36 1.53e-9 IFN-related cytopenia; CESC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg07677032 chr17:61819896 STRADA 0.46 6.0 0.35 6.43e-9 Prudent dietary pattern; CESC cis rs8141529 0.719 rs2097461 chr22:29191879 T/C cg02153584 chr22:29168773 CCDC117 0.7 10.01 0.52 3.2e-20 Lymphocyte counts; CESC cis rs9790314 1.000 rs9846756 chr3:160983809 A/C cg03342759 chr3:160939853 NMD3 -0.49 -6.41 -0.37 6.64e-10 Morning vs. evening chronotype; CESC cis rs861020 0.771 rs654470 chr1:210014093 A/T cg05527609 chr1:210001259 C1orf107 1.06 15.26 0.68 3.65e-38 Orofacial clefts; CESC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.47e-32 Prudent dietary pattern; CESC cis rs7834588 0.523 rs1455578 chr8:63818756 G/T cg20602954 chr8:63776762 NKAIN3 0.31 5.22 0.31 3.58e-7 Response to Vitamin E supplementation; CESC cis rs1003719 0.591 rs2018521 chr21:38517264 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.49 -6.43 -0.37 6.06e-10 Eye color traits; CESC cis rs7580658 0.963 rs4233584 chr2:128060163 C/T cg10021288 chr2:128175891 PROC -0.41 -6.54 -0.37 3.2e-10 Protein C levels; CESC cis rs116095464 0.558 rs113796397 chr5:246503 A/G cg22857025 chr5:266934 NA -1.28 -16.82 -0.72 1.05e-43 Breast cancer; CESC cis rs3126085 0.935 rs11204967 chr1:152249720 A/G cg03465714 chr1:152285911 FLG 0.42 5.51 0.32 8.52e-8 Atopic dermatitis; CESC cis rs8017423 0.967 rs11623275 chr14:90721335 C/T cg14092571 chr14:90743983 NA -0.55 -8.26 -0.45 6.87e-15 Mortality in heart failure; CESC cis rs1003719 0.751 rs55740803 chr21:38542761 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.57 -7.66 -0.43 3.53e-13 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16556111 chr5:92918829 NR2F1 -0.66 -7.6 -0.42 5.2e-13 Gut microbiome composition (summer); CESC cis rs9300255 0.770 rs12299125 chr12:123862447 C/T cg00376283 chr12:123451042 ABCB9 -0.58 -6.67 -0.38 1.45e-10 Neutrophil percentage of white cells; CESC cis rs3733585 0.699 rs6449159 chr4:9960498 G/A cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs7100689 0.646 rs1538815 chr10:82137670 A/G cg00277334 chr10:82204260 NA -0.57 -7.59 -0.42 5.36e-13 Post bronchodilator FEV1; CESC cis rs6460942 1.000 rs79659770 chr7:12326371 T/C cg06484146 chr7:12443880 VWDE -0.82 -8.77 -0.47 2.16e-16 Coronary artery disease; CESC cis rs5769765 1.000 rs5770741 chr22:50270215 A/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg19622623 chr12:86230825 RASSF9 0.45 5.78 0.33 2.13e-8 Major depressive disorder; CESC cis rs8114671 0.562 rs2378294 chr20:33500378 G/A cg06115741 chr20:33292138 TP53INP2 0.47 5.73 0.33 2.73e-8 Height; CESC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg05332525 chr7:65337924 VKORC1L1 0.5 6.17 0.35 2.53e-9 Calcium levels; CESC cis rs3011225 0.691 rs3791102 chr1:44366617 C/T cg15962314 chr1:44399869 ARTN 0.27 5.04 0.3 8.61e-7 Amyotrophic lateral sclerosis (age of onset); CESC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg00166722 chr3:10149974 C3orf24 0.46 5.7 0.33 3.23e-8 Alzheimer's disease; CESC cis rs6460942 1.000 rs112996286 chr7:12315741 G/C cg10578991 chr7:12443926 VWDE -0.61 -6.41 -0.37 6.66e-10 Coronary artery disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg16902244 chr1:24117464 LYPLA2 -0.45 -6.43 -0.37 6.05e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg21724239 chr8:58056113 NA 0.58 5.97 0.34 7.54e-9 Developmental language disorder (linguistic errors); CESC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg11764359 chr7:65958608 NA -0.92 -14.66 -0.67 5e-36 Aortic root size; CESC cis rs2758596 0.850 rs2495270 chr1:156181530 A/G cg24450063 chr1:156163899 SLC25A44 0.81 7.6 0.42 5.01e-13 Paclitaxel disposition in epithelial ovarian cancer; CESC cis rs959260 0.920 rs4789187 chr17:73394784 A/G cg20590849 chr17:73267439 MIF4GD -0.57 -6.29 -0.36 1.31e-9 Systemic lupus erythematosus; CESC cis rs4906332 0.966 rs12588705 chr14:103865477 T/A cg09975044 chr14:104007538 NA 0.46 6.34 0.36 9.93e-10 Coronary artery disease; CESC cis rs6541297 0.703 rs618520 chr1:230309771 T/C cg20703242 chr1:230279135 GALNT2 -0.43 -5.59 -0.33 5.51e-8 Coronary artery disease; CESC cis rs7680126 0.633 rs887732 chr4:10183117 G/C cg11266682 chr4:10021025 SLC2A9 -0.41 -5.28 -0.31 2.75e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg11247378 chr22:39784982 NA -0.65 -9.51 -0.5 1.18e-18 Intelligence (multi-trait analysis); CESC cis rs36051895 0.586 rs12342421 chr9:5065750 G/C cg02405213 chr9:5042618 JAK2 -0.49 -5.85 -0.34 1.45e-8 Pediatric autoimmune diseases; CESC trans rs1728785 1.000 rs6499181 chr16:68593002 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.84 0.43 1.09e-13 Ulcerative colitis; CESC cis rs7267979 1.000 rs1888999 chr20:25291848 C/T cg08601574 chr20:25228251 PYGB 0.35 5.09 0.3 6.78e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs10208940 0.920 rs11893513 chr2:68760647 C/T cg12452813 chr2:68675892 NA 0.51 5.12 0.3 5.77e-7 Urate levels in lean individuals; CESC cis rs2066819 1.000 rs17118409 chr12:56630764 G/A cg26734620 chr12:56694298 CS 1.05 6.75 0.38 9.35e-11 Psoriasis vulgaris; CESC cis rs3096299 0.702 rs2086824 chr16:89471246 G/T cg02187348 chr16:89574699 SPG7 -0.47 -5.9 -0.34 1.08e-8 Multiple myeloma (IgH translocation); CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg07167872 chr1:205819463 PM20D1 0.87 15.56 0.69 3.22e-39 Menarche (age at onset); CESC trans rs7980799 0.935 rs7312012 chr12:33517984 A/G cg26384229 chr12:38710491 ALG10B -0.47 -6.44 -0.37 5.7e-10 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs7212590 0.655 rs16943969 chr17:58031153 A/G cg20303301 chr17:57937339 TUBD1 -0.55 -5.57 -0.32 6.25e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs72781680 1.000 rs72781675 chr2:24232092 G/A cg20701182 chr2:24300061 SF3B14 0.79 6.92 0.39 3.37e-11 Lymphocyte counts; CESC cis rs9399135 0.967 rs9389254 chr6:135330709 C/T cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.43e-7 Tonsillectomy; CESC cis rs3806843 0.648 rs702399 chr5:140024432 C/T cg26395211 chr5:140044315 WDR55 0.45 5.69 0.33 3.36e-8 Depressive symptoms (multi-trait analysis); CESC cis rs7959452 1.000 rs7959452 chr12:69735492 A/G cg20891283 chr12:69753455 YEATS4 0.57 7.72 0.43 2.38e-13 Blood protein levels; CESC cis rs6460942 1.000 rs6970095 chr7:12403840 G/A cg17427002 chr7:12443146 VWDE -0.52 -5.27 -0.31 2.82e-7 Coronary artery disease; CESC cis rs116095464 0.558 rs7713524 chr5:276200 C/T cg22857025 chr5:266934 NA 1.28 18.9 0.76 5.1e-51 Breast cancer; CESC cis rs7527798 0.592 rs12144801 chr1:207857773 A/G cg21110645 chr1:207815933 NA -0.33 -5.86 -0.34 1.33e-8 Erythrocyte sedimentation rate; CESC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg11663144 chr21:46675770 NA -0.62 -9.77 -0.51 1.85e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs116095464 0.558 rs2288458 chr5:231260 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.22 0.31 3.68e-7 Breast cancer; CESC cis rs10751667 0.666 rs6597960 chr11:977036 C/T cg06064525 chr11:970664 AP2A2 -0.47 -9.12 -0.49 1.9e-17 Alzheimer's disease (late onset); CESC cis rs7665939 1.000 rs72727639 chr4:190107992 G/C cg09826759 chr4:190284978 NA -0.87 -7.17 -0.4 7.56e-12 Amyotrophic lateral sclerosis; CESC cis rs9325144 0.560 rs11183090 chr12:38662293 G/C cg26384229 chr12:38710491 ALG10B -0.62 -9.6 -0.51 6.43e-19 Morning vs. evening chronotype; CESC cis rs72945132 0.882 rs56176527 chr11:70162513 A/G cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs67311347 0.544 rs2887965 chr3:40334154 A/G cg09455208 chr3:40491958 NA -0.37 -6.65 -0.38 1.71e-10 Renal cell carcinoma; CESC cis rs763014 0.931 rs59476302 chr16:629006 C/T cg07343612 chr16:622815 PIGQ -0.57 -8.42 -0.46 2.43e-15 Height; CESC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg18538332 chr22:24372958 LOC391322 0.66 9.36 0.5 3.68e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6690583 0.623 rs898036 chr1:85521904 A/T cg22153463 chr1:85462885 MCOLN2 0.77 7.48 0.42 1.11e-12 Serum sulfate level; CESC cis rs8038465 0.874 rs2291011 chr15:74000839 G/A cg15420318 chr15:73925796 NPTN 0.4 5.64 0.33 4.32e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs8014204 0.836 rs12588415 chr14:75278211 G/A cg08847533 chr14:75593920 NEK9 0.46 5.82 0.34 1.69e-8 Caffeine consumption; CESC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg02297831 chr4:17616191 MED28 0.66 8.2 0.45 1.06e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs7726839 0.540 rs72703092 chr5:599269 G/A cg25482853 chr8:67687455 SGK3 1.04 10.14 0.53 1.27e-20 Obesity-related traits; CESC cis rs12681288 0.782 rs12549337 chr8:1030187 A/G cg15309053 chr8:964076 NA 0.39 6.08 0.35 4.06e-9 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14908186 chr13:113863106 CUL4A;PCID2 -0.46 -6.18 -0.35 2.36e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10182541 chr17:7145706 GABARAP 0.59 6.48 0.37 4.38e-10 Gut microbiome composition (summer); CESC cis rs73206853 0.698 rs56327628 chr12:111117931 A/C cg12870014 chr12:110450643 ANKRD13A 0.64 5.25 0.31 3.11e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs6665290 0.904 rs1045252 chr1:227181555 A/G cg10327440 chr1:227177885 CDC42BPA -1.22 -34.49 -0.9 5.68e-100 Myeloid white cell count; CESC cis rs9902453 0.791 rs7219163 chr17:28210703 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.82 0.48 1.58e-16 Coffee consumption (cups per day); CESC cis rs941873 0.900 rs4979862 chr10:81131599 G/A cg11057378 chr10:81107060 PPIF 0.35 5.6 0.33 5.37e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16376036 chr11:117015095 PAFAH1B2 0.5 6.33 0.36 1.01e-9 Gut microbiome composition (summer); CESC cis rs7914558 1.000 rs2275271 chr10:104814162 T/C cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.49e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7904368 0.568 rs7075036 chr10:16864810 C/T cg23933602 chr10:16859644 RSU1 0.9 13.78 0.65 6.23e-33 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs936229 1.000 rs936228 chr15:75132164 T/C cg14664628 chr15:75095509 CSK -0.84 -11.32 -0.57 1.77e-24 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs2243480 0.711 rs1626926 chr7:65435792 C/T cg12463550 chr7:65579703 CRCP 0.67 5.54 0.32 7.11e-8 Diabetic kidney disease; CESC cis rs1564271 0.506 rs1148163 chr10:26929671 G/C cg13837822 chr10:26931731 LOC731789 0.47 7.04 0.4 1.61e-11 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CESC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg24531977 chr5:56204891 C5orf35 -0.49 -5.87 -0.34 1.3e-8 Coronary artery disease; CESC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs854765 0.618 rs8066982 chr17:17851377 T/C cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC cis rs1267303 0.642 rs3737740 chr1:47000596 G/A cg25110126 chr1:46999211 NA 1.06 11.91 0.59 1.8e-26 Monobrow; CESC trans rs11039798 1.000 rs115429994 chr11:48761183 C/G cg15704280 chr7:45808275 SEPT13 0.7 6.42 0.37 6.38e-10 Axial length; CESC cis rs709400 0.628 rs6575983 chr14:103869849 C/G cg12935359 chr14:103987150 CKB -0.45 -6.87 -0.39 4.66e-11 Body mass index; CESC cis rs2479724 0.901 rs33954419 chr6:41786136 A/G cg17623882 chr6:41773611 USP49 -0.39 -5.48 -0.32 9.83e-8 Menarche (age at onset); CESC cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg07507251 chr3:52567010 NT5DC2 -0.33 -5.51 -0.32 8.65e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs4332037 0.950 rs62442895 chr7:1936938 G/A cg23422044 chr7:1970798 MAD1L1 -0.53 -5.39 -0.31 1.58e-7 Bipolar disorder; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16080015 chr7:5085479 RBAK 0.46 6.35 0.36 9.21e-10 Intelligence (multi-trait analysis); CESC cis rs10857712 0.754 rs2297031 chr10:135232654 C/T cg01444801 chr10:135216882 MTG1 -0.47 -5.41 -0.32 1.44e-7 Systemic lupus erythematosus; CESC cis rs1976403 0.510 rs1697421 chr1:21823292 C/T cg04349561 chr1:21808255 NBPF3 -0.37 -5.3 -0.31 2.43e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs763014 0.931 rs11648728 chr16:635525 C/T cg09781414 chr16:715207 WDR90 -0.33 -5.04 -0.3 8.57e-7 Height; CESC cis rs9300255 0.568 rs1790102 chr12:123704890 G/A cg00376283 chr12:123451042 ABCB9 0.7 8.89 0.48 9.66e-17 Neutrophil percentage of white cells; CESC cis rs7107174 1.000 rs10899479 chr11:78052539 A/G cg02023728 chr11:77925099 USP35 0.47 6.25 0.36 1.63e-9 Testicular germ cell tumor; CESC cis rs3733585 0.673 rs10018204 chr4:9964570 C/T cg02734326 chr4:10020555 SLC2A9 -0.44 -6.1 -0.35 3.77e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7647973 1.000 rs11710434 chr3:49346130 T/C cg06212747 chr3:49208901 KLHDC8B 0.59 7.8 0.43 1.42e-13 Menarche (age at onset); CESC cis rs728616 0.867 rs723191 chr10:81707920 A/G cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6575793 1.000 rs8006543 chr14:101033420 C/T cg18516195 chr14:101012996 BEGAIN 0.47 6.41 0.37 6.55e-10 Menarche (age at onset); CESC cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.3 -5.11 -0.3 6.27e-7 Hemoglobin concentration; CESC cis rs9894429 0.869 rs9748184 chr17:79596280 A/G cg13777783 chr17:79615861 NA -0.34 -5.65 -0.33 4.22e-8 Eye color traits; CESC cis rs6662572 0.737 rs4474301 chr1:46255272 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.08 -0.3 7.27e-7 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07473634 chr13:113647389 MCF2L -0.47 -6.29 -0.36 1.33e-9 Gut microbiome composition (summer); CESC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg11764359 chr7:65958608 NA -0.67 -8.72 -0.47 3.06e-16 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13116478 chr1:9217203 NA 0.46 6.36 0.36 8.66e-10 Fibrinogen levels; CESC cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg10792982 chr14:105748885 BRF1 0.42 5.53 0.32 7.54e-8 Mean platelet volume;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11087911 chr8:64081408 YTHDF3 0.57 6.41 0.37 6.45e-10 Gut microbiome composition (summer); CESC cis rs12618769 0.652 rs17034171 chr2:99221095 A/G cg10123293 chr2:99228465 UNC50 0.4 5.32 0.31 2.2e-7 Bipolar disorder; CESC cis rs12477438 0.765 rs10193039 chr2:99692373 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -8.65 -0.47 5.2e-16 Chronic sinus infection; CESC cis rs4722166 0.695 rs4722177 chr7:22798531 T/C cg05472934 chr7:22766657 IL6 0.63 8.31 0.45 4.87e-15 Lung cancer; CESC trans rs3741404 0.825 rs60452247 chr11:63981507 G/A cg15268290 chr11:83690587 DLG2 0.43 6.03 0.35 5.48e-9 Platelet count; CESC cis rs6831352 0.918 rs13110764 chr4:100062466 C/T cg12011299 chr4:100065546 ADH4 -0.57 -6.5 -0.37 3.86e-10 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19863752 chr5:175970067 NA 0.53 6.0 0.35 6.36e-9 Gut microbiome composition (summer); CESC cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg24130564 chr14:104152367 KLC1 -0.51 -6.72 -0.38 1.08e-10 Reticulocyte count; CESC cis rs17376456 0.877 rs12716460 chr5:93416733 A/G cg21475434 chr5:93447410 FAM172A 0.82 7.36 0.41 2.32e-12 Diabetic retinopathy; CESC cis rs78707713 0.535 rs3812705 chr10:71211146 A/G cg12610070 chr10:71211762 TSPAN15 -0.32 -6.87 -0.39 4.44e-11 Venous thromboembolism; CESC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs757110 0.770 rs4439492 chr11:17386733 C/T cg15432903 chr11:17409602 KCNJ11 0.58 8.14 0.45 1.5e-14 Type 2 diabetes; CESC cis rs9488822 0.676 rs4354188 chr6:116327936 T/C cg26893134 chr6:116381904 FRK 0.25 6.02 0.35 5.89e-9 Cholesterol, total;LDL cholesterol; CESC trans rs61931739 0.500 rs11615231 chr12:34413330 T/C cg13010199 chr12:38710504 ALG10B 0.49 6.34 0.36 9.81e-10 Morning vs. evening chronotype; CESC trans rs7824557 0.527 rs4634600 chr8:11239017 T/A cg06636001 chr8:8085503 FLJ10661 -0.48 -6.23 -0.36 1.83e-9 Retinal vascular caliber; CESC cis rs9929218 0.817 rs3118228 chr16:68710737 T/G cg02972257 chr16:68554789 NA 0.55 6.06 0.35 4.57e-9 Colorectal cancer; CESC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg23161317 chr6:28129485 ZNF389 0.51 6.5 0.37 3.98e-10 Parkinson's disease; CESC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg01416388 chr22:39784598 NA -0.64 -7.0 -0.4 2.09e-11 IgG glycosylation; CESC cis rs9325144 0.505 rs6582691 chr12:38806894 T/C cg13010199 chr12:38710504 ALG10B -0.48 -6.82 -0.39 6.08e-11 Morning vs. evening chronotype; CESC cis rs9549367 0.713 rs4907598 chr13:113861385 C/T cg00898013 chr13:113819073 PROZ 0.45 6.92 0.39 3.35e-11 Platelet distribution width; CESC cis rs4664293 0.967 rs35975814 chr2:160547791 G/A cg08347373 chr2:160653686 CD302 -0.33 -5.38 -0.31 1.66e-7 Monocyte percentage of white cells; CESC cis rs9814567 1.000 rs6802654 chr3:134217072 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.99 -0.35 6.9e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6088590 1.000 rs2236270 chr20:33523155 G/T cg06115741 chr20:33292138 TP53INP2 0.64 7.76 0.43 1.85e-13 Coronary artery disease; CESC cis rs9311474 0.713 rs352166 chr3:52238677 C/T cg05564831 chr3:52568323 NT5DC2 0.34 5.06 0.3 8.01e-7 Electroencephalogram traits; CESC cis rs2228479 0.850 rs3785281 chr16:89824263 G/C cg06558623 chr16:89946397 TCF25 1.17 9.38 0.5 3.19e-18 Skin colour saturation; CESC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg22823121 chr1:150693482 HORMAD1 0.37 5.22 0.31 3.62e-7 Melanoma; CESC cis rs10242455 0.702 rs73403286 chr7:99154865 A/C cg25640893 chr7:99214727 ZNF498 0.78 5.5 0.32 8.75e-8 Blood metabolite levels; CESC cis rs847577 0.609 rs17435847 chr7:97792820 G/A cg21770322 chr7:97807741 LMTK2 0.86 14.88 0.67 8e-37 Breast cancer; CESC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg11247378 chr22:39784982 NA -0.69 -9.46 -0.5 1.79e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs5758511 0.508 rs28715885 chr22:42441091 T/G cg00645731 chr22:42541494 CYP2D7P1 0.55 7.51 0.42 8.91e-13 Birth weight; CESC cis rs3733585 0.781 rs4292328 chr4:9970962 C/T cg00071950 chr4:10020882 SLC2A9 -0.79 -14.74 -0.67 2.47e-36 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg12292205 chr6:26970375 C6orf41 -0.5 -5.72 -0.33 2.9e-8 Intelligence (multi-trait analysis); CESC cis rs10504229 0.724 rs72649117 chr8:58037639 A/G cg22535103 chr8:58192502 C8orf71 -0.6 -6.76 -0.38 8.68e-11 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs16867321 0.590 rs2194688 chr2:181577733 C/G cg23363182 chr2:181467187 NA 0.45 6.63 0.38 1.87e-10 Obesity; CESC cis rs6598955 1.000 rs10902728 chr1:26598281 T/C cg04990556 chr1:26633338 UBXN11 0.84 10.87 0.56 5.24e-23 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00911289 chr3:128840257 RAB43 -0.63 -6.94 -0.39 2.98e-11 Gut microbiome composition (summer); CESC cis rs6893300 0.961 rs11744616 chr5:179209113 G/T cg14593053 chr5:179126677 CANX -0.51 -5.69 -0.33 3.44e-8 Resting heart rate; CESC cis rs9457247 0.967 rs2149084 chr6:167370988 G/C cg07741184 chr6:167504864 NA -0.3 -5.25 -0.31 3.1e-7 Crohn's disease; CESC cis rs360798 0.532 rs2421816 chr2:63075033 C/A cg17519650 chr2:63277830 OTX1 0.48 5.76 0.33 2.32e-8 Coronary artery disease; CESC cis rs9911578 0.803 rs8069033 chr17:57131581 T/A cg12560992 chr17:57184187 TRIM37 -1.02 -17.96 -0.74 9.86e-48 Intelligence (multi-trait analysis); CESC cis rs258892 0.841 rs266427 chr5:72130751 A/G cg21869765 chr5:72125136 TNPO1 0.44 5.62 0.33 4.78e-8 Small cell lung carcinoma; CESC cis rs2635047 0.967 rs2668786 chr18:44708472 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 7.13 0.4 9.45e-12 Educational attainment; CESC cis rs7914558 0.966 rs1971589 chr10:104744406 A/G cg08650961 chr10:104748594 CNNM2 0.32 5.18 0.3 4.39e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7243790 0.805 rs12458588 chr18:51903693 G/T cg04730925 chr18:51795821 POLI -0.42 -5.58 -0.32 5.95e-8 Diastolic blood pressure; CESC cis rs1045714 0.895 rs4721860 chr7:2639994 C/T cg20813462 chr7:2646259 IQCE 0.65 5.65 0.33 4.16e-8 Urate levels in lean individuals; CESC cis rs7103648 0.669 rs7114011 chr11:47811309 A/C cg10504702 chr11:47789108 FNBP4 0.41 5.17 0.3 4.63e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs62229266 0.693 rs2835264 chr21:37435965 C/T cg08632701 chr21:37451849 NA -0.4 -5.58 -0.32 6.01e-8 Mitral valve prolapse; CESC cis rs4664293 0.967 rs9646765 chr2:160565648 T/C cg08347373 chr2:160653686 CD302 -0.33 -5.35 -0.31 1.95e-7 Monocyte percentage of white cells; CESC cis rs10979 1.000 rs35354710 chr6:143886454 A/G cg25407410 chr6:143891975 LOC285740 -0.62 -9.52 -0.51 1.1e-18 Hypospadias; CESC cis rs7084402 0.935 rs4948524 chr10:60351224 C/A cg07615347 chr10:60278583 BICC1 0.54 8.28 0.45 6.13e-15 Refractive error; CESC cis rs11112613 0.762 rs17037308 chr12:105949847 T/G cg03607813 chr12:105948248 NA 0.67 8.31 0.45 5.16e-15 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg02018176 chr4:1364513 KIAA1530 -0.38 -5.07 -0.3 7.43e-7 Obesity-related traits; CESC cis rs5769765 0.837 rs8142737 chr22:50291889 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.44 -5.09 -0.3 6.87e-7 Schizophrenia; CESC cis rs4268898 0.662 rs12052954 chr2:24425620 C/T cg08917208 chr2:24149416 ATAD2B -0.54 -5.42 -0.32 1.31e-7 Asthma; CESC cis rs10927875 0.632 rs2862162 chr1:16142960 A/C cg19025461 chr1:16163610 FLJ37453 -0.35 -5.12 -0.3 5.82e-7 Dilated cardiomyopathy; CESC trans rs8026198 0.568 rs1659221 chr15:42615411 A/C cg11538410 chr8:142141455 DENND3 0.61 6.04 0.35 5.11e-9 Fibrinogen levels; CESC cis rs11625487 0.609 rs78677337 chr14:77966223 G/A cg20045696 chr14:77926864 AHSA1 -0.71 -5.27 -0.31 2.88e-7 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg02297831 chr4:17616191 MED28 0.45 5.47 0.32 1.04e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg11663144 chr21:46675770 NA 0.56 8.73 0.47 2.9e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs853679 0.607 rs17763089 chr6:27835218 G/A cg01620082 chr3:125678407 NA -0.76 -6.48 -0.37 4.51e-10 Depression; CESC cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg23422044 chr7:1970798 MAD1L1 -0.54 -5.78 -0.33 2.12e-8 Bipolar disorder; CESC cis rs9911578 1.000 rs2079703 chr17:56603978 G/A cg12560992 chr17:57184187 TRIM37 -0.93 -15.59 -0.69 2.43e-39 Intelligence (multi-trait analysis); CESC trans rs637571 0.780 rs677029 chr11:65683531 A/G cg17712092 chr4:129076599 LARP1B 0.94 13.86 0.65 3.29e-33 Eosinophil percentage of white cells; CESC cis rs11864453 0.713 rs3764312 chr16:72125733 A/C cg01557791 chr16:72042693 DHODH -0.46 -5.92 -0.34 9.98e-9 Fibrinogen levels; CESC trans rs9650657 0.538 rs6984496 chr8:10796093 G/T cg15556689 chr8:8085844 FLJ10661 -0.58 -7.4 -0.41 1.75e-12 Neuroticism; CESC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg18099408 chr3:52552593 STAB1 -0.38 -6.6 -0.38 2.24e-10 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09690373 chr8:29120781 KIF13B -0.71 -8.96 -0.48 6.12e-17 Gut microbiome composition (summer); CESC cis rs6430585 0.583 rs2839740 chr2:136648883 G/T cg07169764 chr2:136633963 MCM6 1.27 17.79 0.74 4.01e-47 Corneal structure; CESC cis rs62283056 0.636 rs17718958 chr4:6275735 G/A cg00701064 chr4:6280414 WFS1 -0.57 -5.26 -0.31 2.92e-7 Cisplatin-induced ototoxicity; CESC cis rs9309473 1.000 rs10187416 chr2:73713741 T/G cg20560298 chr2:73613845 ALMS1 -0.49 -6.69 -0.38 1.3e-10 Metabolite levels; CESC trans rs561341 1.000 rs501312 chr17:30329066 A/G cg20587970 chr11:113659929 NA -1.43 -18.64 -0.75 3.98e-50 Hip circumference adjusted for BMI; CESC cis rs9403521 1.000 rs12528456 chr6:144003706 A/G cg18240653 chr6:144019428 PHACTR2 -0.46 -5.24 -0.31 3.35e-7 Obesity-related traits; CESC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg12311346 chr5:56204834 C5orf35 -0.56 -7.1 -0.4 1.17e-11 Type 2 diabetes; CESC cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg08564027 chr20:61660810 NA 0.91 15.61 0.69 2.1e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs656900 0.715 rs673079 chr15:80115406 G/A cg02196730 chr15:80188777 MTHFS -0.39 -5.03 -0.3 9.2e-7 Cerebrospinal P-tau181p levels; CESC cis rs7937682 0.737 rs663763 chr11:111422217 C/T cg09085632 chr11:111637200 PPP2R1B -0.76 -10.13 -0.53 1.34e-20 Primary sclerosing cholangitis; CESC cis rs3820068 0.581 rs16851848 chr1:15927698 G/A cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg22903471 chr2:27725779 GCKR -0.5 -7.16 -0.4 7.71e-12 Total body bone mineral density; CESC cis rs2730245 0.505 rs1188956 chr7:158690576 G/A cg14689365 chr7:158441557 NCAPG2 0.42 5.25 0.31 3.18e-7 Height; CESC cis rs926938 0.618 rs360617 chr1:115404099 G/A cg12756093 chr1:115239321 AMPD1 0.48 6.79 0.38 7.45e-11 Autism; CESC cis rs8114671 0.562 rs1060615 chr20:33478381 C/T cg07148914 chr20:33460835 GGT7 -0.43 -5.7 -0.33 3.12e-8 Height; CESC cis rs7223966 1.000 rs2665826 chr17:61944924 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.32 0.36 1.1e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4595586 0.545 rs12820138 chr12:39357049 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC cis rs3733585 0.699 rs6449159 chr4:9960498 G/A cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg16680214 chr1:154839983 KCNN3 -0.52 -8.24 -0.45 7.81e-15 Prostate cancer; CESC cis rs56046484 0.956 rs34054841 chr15:85601346 C/G cg08123816 chr15:85640762 PDE8A -0.48 -6.03 -0.35 5.39e-9 Testicular germ cell tumor; CESC cis rs4253772 0.591 rs6008361 chr22:46652372 A/G cg24881330 chr22:46731750 TRMU -0.85 -9.56 -0.51 8.81e-19 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs539096 0.540 rs37452 chr1:44297573 A/C cg12908607 chr1:44402522 ARTN -0.46 -6.77 -0.38 8.18e-11 Intelligence (multi-trait analysis); CESC cis rs902774 0.554 rs4919749 chr12:53358034 C/T cg05393297 chr12:53359155 NA -0.64 -9.09 -0.49 2.45e-17 Prostate cancer; CESC cis rs854765 0.724 rs62072049 chr17:17906520 T/C cg09796270 chr17:17721594 SREBF1 0.45 6.43 0.37 5.78e-10 Total body bone mineral density; CESC cis rs561341 0.941 rs8066558 chr17:30272879 G/T cg00745463 chr17:30367425 LRRC37B -0.68 -6.78 -0.38 7.66e-11 Hip circumference adjusted for BMI; CESC cis rs78456975 0.943 rs7602369 chr2:1574754 T/C cg26248373 chr2:1572462 NA -0.54 -5.25 -0.31 3.14e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs8060686 0.641 rs79375669 chr16:68099262 A/T cg26727032 chr16:67993705 SLC12A4 -0.55 -6.15 -0.35 2.9e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg19052272 chr2:3704530 ALLC -0.48 -5.85 -0.34 1.41e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC trans rs6570726 0.764 rs9403726 chr6:145901686 G/T cg03826317 chr10:25465503 LOC100128811;GPR158 0.31 6.11 0.35 3.47e-9 Lobe attachment (rater-scored or self-reported); CESC trans rs9858542 0.953 rs9858280 chr3:49597737 T/C cg21659725 chr3:3221576 CRBN -0.52 -6.36 -0.36 8.69e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs3824867 0.879 rs4752837 chr11:47465955 G/A cg20307385 chr11:47447363 PSMC3 0.51 6.09 0.35 3.96e-9 Mean corpuscular hemoglobin; CESC cis rs4730250 0.707 rs3729876 chr7:106786952 T/C cg02696742 chr7:106810147 HBP1 0.56 5.3 0.31 2.45e-7 Osteoarthritis; CESC cis rs11098499 0.779 rs10857066 chr4:120286596 C/T cg24375607 chr4:120327624 NA 0.42 5.18 0.3 4.34e-7 Corneal astigmatism; CESC cis rs896543 0.657 rs10179774 chr2:237487588 C/T cg25295825 chr2:237489920 CXCR7 0.55 6.22 0.36 1.89e-9 Alcohol dependence (age at onset); CESC cis rs1505368 0.567 rs972491 chr2:213316573 A/G cg20637307 chr2:213403960 ERBB4 -0.45 -7.04 -0.4 1.64e-11 Symmetrical dimethylarginine levels; CESC cis rs16867321 0.639 rs13028421 chr2:181444035 G/T cg23363182 chr2:181467187 NA 0.5 7.37 0.41 2.12e-12 Obesity; CESC cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg13902645 chr11:5959945 NA -0.62 -7.29 -0.41 3.54e-12 DNA methylation (variation); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04730839 chr6:42985884 KLHDC3 -0.37 -6.09 -0.35 3.98e-9 Gambling; CESC cis rs17376456 0.877 rs10044139 chr5:93407803 T/C cg25358565 chr5:93447407 FAM172A 1.13 10.9 0.56 4.19e-23 Diabetic retinopathy; CESC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg03351412 chr1:154909251 PMVK 0.68 8.94 0.48 6.9e-17 Prostate cancer; CESC cis rs28374715 0.681 rs59000092 chr15:41626148 A/G cg18705301 chr15:41695430 NDUFAF1 -0.78 -11.24 -0.57 3.19e-24 Ulcerative colitis; CESC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg11764359 chr7:65958608 NA 0.89 13.96 0.65 1.41e-33 Aortic root size; CESC cis rs962856 0.619 rs6546300 chr2:67595196 T/G cg09028215 chr2:67624308 ETAA1 -0.44 -5.29 -0.31 2.54e-7 Pancreatic cancer; CESC cis rs11122272 0.735 rs2790885 chr1:231529925 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg03467027 chr4:99064603 C4orf37 -0.49 -6.15 -0.35 2.89e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7605827 0.893 rs7575722 chr2:15597551 G/A cg19274914 chr2:15703543 NA 0.32 5.61 0.33 5.05e-8 Educational attainment (years of education); CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg06611277 chr10:26987120 PDSS1 -0.54 -6.12 -0.35 3.43e-9 Subjective well-being; CESC cis rs3733585 0.699 rs6449174 chr4:9966422 C/T cg00071950 chr4:10020882 SLC2A9 -0.66 -10.67 -0.55 2.49e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs116095464 0.558 rs28418643 chr5:240859 A/G cg22857025 chr5:266934 NA -1.29 -18.85 -0.76 7.29e-51 Breast cancer; CESC cis rs73019876 0.869 rs7253518 chr19:22145667 C/T cg11619707 chr19:22235551 ZNF257 -0.28 -5.19 -0.3 4.11e-7 Testicular germ cell tumor; CESC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg13175981 chr1:150552382 MCL1 0.62 9.15 0.49 1.59e-17 Tonsillectomy; CESC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg24578937 chr1:2090814 PRKCZ -0.32 -5.51 -0.32 8.62e-8 Height; CESC trans rs10242455 0.571 rs55830753 chr7:99292222 A/G cg09045935 chr12:6379348 NA 0.76 6.07 0.35 4.42e-9 Blood metabolite levels; CESC cis rs959260 0.688 rs1435093 chr17:73357586 G/A cg20590849 chr17:73267439 MIF4GD -0.56 -6.11 -0.35 3.55e-9 Systemic lupus erythematosus; CESC cis rs9457247 0.534 rs4710149 chr6:167386346 T/C cg23791538 chr6:167370224 RNASET2 0.7 10.12 0.53 1.44e-20 Crohn's disease; CESC cis rs920590 0.758 rs1817836 chr8:19664852 T/C cg03894339 chr8:19674705 INTS10 0.62 7.36 0.41 2.35e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs34779708 0.658 rs4934715 chr10:35364992 G/T cg03585969 chr10:35415529 CREM 0.76 9.79 0.52 1.5700000000000001e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 10.96 0.56 2.75e-23 Platelet count; CESC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg18876405 chr7:65276391 NA -0.5 -6.92 -0.39 3.39e-11 Aortic root size; CESC cis rs6570726 0.967 rs6903252 chr6:145922777 A/G cg23711669 chr6:146136114 FBXO30 0.79 11.69 0.58 9.6e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs9309473 1.000 rs7580825 chr2:73635148 G/A cg20560298 chr2:73613845 ALMS1 -0.55 -7.19 -0.4 6.6e-12 Metabolite levels; CESC cis rs11252926 0.624 rs7085214 chr10:468133 A/G cg03684893 chr10:554711 DIP2C -0.39 -5.83 -0.34 1.59e-8 Psychosis in Alzheimer's disease; CESC cis rs35110281 0.563 rs162371 chr21:44931489 G/T cg01579765 chr21:45077557 HSF2BP -0.51 -8.73 -0.47 2.83e-16 Mean corpuscular volume; CESC cis rs72781680 0.898 rs12623333 chr2:24111823 T/G cg08917208 chr2:24149416 ATAD2B 0.93 8.61 0.47 6.66e-16 Lymphocyte counts; CESC cis rs2832191 0.720 rs7277028 chr21:30494604 T/C cg24692254 chr21:30365293 RNF160 -0.79 -12.11 -0.6 3.54e-27 Dental caries; CESC cis rs72781680 0.821 rs72790329 chr2:24129277 A/G cg08917208 chr2:24149416 ATAD2B 0.57 5.62 0.33 4.79e-8 Lymphocyte counts; CESC cis rs763121 0.853 rs2281019 chr22:39064378 T/A cg06022373 chr22:39101656 GTPBP1 0.88 13.95 0.65 1.51e-33 Menopause (age at onset); CESC cis rs6121246 0.559 rs10439607 chr20:30258541 G/A cg13852791 chr20:30311386 BCL2L1 0.76 9.73 0.51 2.51e-19 Mean corpuscular hemoglobin; CESC cis rs10751667 0.600 rs10751665 chr11:941300 G/A cg20946044 chr11:1010712 AP2A2 -0.41 -5.64 -0.33 4.31e-8 Alzheimer's disease (late onset); CESC cis rs2415984 0.622 rs10131871 chr14:46931700 A/G cg14871534 chr14:47121158 RPL10L 0.35 5.42 0.32 1.36e-7 Number of children ever born; CESC cis rs5758659 0.682 rs133306 chr22:42396150 G/A cg15557168 chr22:42548783 NA -0.43 -6.34 -0.36 9.99e-10 Cognitive function; CESC cis rs2282526 0.587 rs91424 chr21:44921161 A/G cg01579765 chr21:45077557 HSF2BP 0.4 6.35 0.36 9.35e-10 Mean corpuscular hemoglobin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08979686 chr20:44600644 ZNF335 0.5 6.15 0.35 2.88e-9 Gut microbiome composition (summer); CESC cis rs2404602 0.672 rs35374222 chr15:77071394 G/T cg23625390 chr15:77176239 SCAPER -0.4 -5.23 -0.31 3.44e-7 Blood metabolite levels; CESC cis rs6570726 0.846 rs1935616 chr6:145943512 C/T cg05347473 chr6:146136440 FBXO30 0.53 6.89 0.39 4.01e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1008375 1.000 rs10939748 chr4:17691230 T/C cg16339924 chr4:17578868 LAP3 0.64 7.7 0.43 2.69e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2594989 0.895 rs2606741 chr3:11392426 G/A cg00170343 chr3:11313890 ATG7 0.48 5.15 0.3 4.97e-7 Circulating chemerin levels; CESC cis rs870825 0.616 rs6814278 chr4:185644417 G/C cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs718433 0.616 rs2222916 chr14:22212602 C/T cg02257791 chr14:22217085 NA -0.32 -5.09 -0.3 6.83e-7 Intraocular pressure; CESC cis rs7714584 1.000 rs75071288 chr5:150224379 C/T cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10168434 chr2:71295172 NAGK 0.58 6.34 0.36 9.76e-10 Gut microbiome composition (summer); CESC cis rs11871801 1.000 rs12938856 chr17:40570649 T/C cg21433558 chr17:40837037 CNTNAP1 0.46 5.03 0.3 8.91e-7 Crohn's disease; CESC cis rs7918232 0.830 rs7915902 chr10:27410734 T/C cg14442939 chr10:27389572 ANKRD26 0.68 6.73 0.38 1.04e-10 Breast cancer; CESC cis rs3820928 1.000 rs4675116 chr2:227769607 A/C cg05526886 chr2:227700861 RHBDD1 -0.44 -5.76 -0.33 2.36e-8 Pulmonary function; CESC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 11.36 0.57 1.23e-24 Alzheimer's disease; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg01034784 chr2:95831832 ZNF2 -0.4 -6.2 -0.36 2.21e-9 Vertical cup-disc ratio; CESC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg20295408 chr7:1910781 MAD1L1 0.43 5.55 0.32 6.95e-8 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12629250 chr15:20149347 NA -0.59 -6.74 -0.38 9.94e-11 Gut microbiome composition (summer); CESC trans rs2235573 0.551 rs84770 chr22:38390128 T/G cg19894588 chr14:64061835 NA 0.6 7.74 0.43 2.14e-13 Glioblastoma;Glioma; CESC cis rs67478160 0.583 rs12879612 chr14:104233618 T/A cg08213375 chr14:104286397 PPP1R13B 0.55 11.06 0.56 1.25e-23 Schizophrenia; CESC cis rs9911578 0.935 rs420878 chr17:56709077 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.17 0.3 4.54e-7 Intelligence (multi-trait analysis); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg09783738 chr11:109964017 ZC3H12C 0.44 6.05 0.35 5.01e-9 Thyroid stimulating hormone; CESC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg16325326 chr1:53192061 ZYG11B 0.82 13.0 0.62 3.08e-30 Monocyte count; CESC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg17372223 chr3:52568218 NT5DC2 0.38 5.68 0.33 3.48e-8 Bipolar disorder; CESC cis rs11608355 0.672 rs9943689 chr12:109890339 G/A cg05360138 chr12:110035743 NA 0.54 6.03 0.35 5.44e-9 Neuroticism; CESC cis rs533581 0.866 rs562812 chr16:88970944 G/A cg16701003 chr16:89028210 CBFA2T3 0.48 6.61 0.38 2.1e-10 Social autistic-like traits; CESC cis rs712039 0.652 rs829161 chr17:35763863 C/T cg16670864 chr17:35848621 DUSP14 -0.44 -5.73 -0.33 2.7e-8 Tuberculosis; CESC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg01988459 chr11:68622903 NA -0.41 -5.65 -0.33 4.1e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9303401 0.703 rs9911583 chr17:57210721 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.54 -7.03 -0.4 1.79e-11 Cognitive test performance; CESC cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg22875332 chr1:76189707 ACADM 0.66 7.79 0.43 1.53e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9487051 0.676 rs9398196 chr6:109601554 A/G cg01475377 chr6:109611718 NA -0.45 -7.1 -0.4 1.13e-11 Reticulocyte fraction of red cells; CESC cis rs9322193 0.607 rs12210822 chr6:150226492 C/T cg01145232 chr6:150245071 RAET1G 0.52 6.64 0.38 1.79e-10 Lung cancer; CESC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg12963246 chr6:28129442 ZNF389 0.5 6.4 0.37 6.93e-10 Parkinson's disease; CESC cis rs6460942 1.000 rs73053531 chr7:12317474 T/C cg10578991 chr7:12443926 VWDE -0.61 -6.41 -0.37 6.66e-10 Coronary artery disease; CESC cis rs10751667 0.621 rs4075990 chr11:976614 T/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.48e-7 Alzheimer's disease (late onset); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg01398415 chr1:226309536 NA 0.46 6.12 0.35 3.36e-9 Systemic lupus erythematosus; CESC trans rs11098499 0.698 rs4422403 chr4:120258194 C/T cg25214090 chr10:38739885 LOC399744 0.61 8.64 0.47 5.37e-16 Corneal astigmatism; CESC cis rs2235544 0.664 rs12036530 chr1:54476323 T/C cg09175620 chr1:54484536 LDLRAD1 -0.29 -5.09 -0.3 6.88e-7 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs11030122 0.702 rs4910866 chr11:3950554 A/T cg18678763 chr11:4115507 RRM1 -0.45 -6.05 -0.35 4.94e-9 Mean platelet volume;Platelet distribution width; CESC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg22823121 chr1:150693482 HORMAD1 0.36 5.07 0.3 7.36e-7 Melanoma; CESC cis rs7474896 0.515 rs2505233 chr10:38340265 C/T cg25427524 chr10:38739819 LOC399744 -0.44 -5.09 -0.3 6.89e-7 Obesity (extreme); CESC cis rs28680850 0.541 rs28501642 chr8:1379528 G/A cg06035437 chr8:1398411 NA -0.49 -5.12 -0.3 5.95e-7 Triglycerides; CESC trans rs1941687 0.527 rs1493914 chr18:31362327 C/T cg27147174 chr7:100797783 AP1S1 -0.5 -6.71 -0.38 1.16e-10 Subjective well-being (multi-trait analysis);Subjective well-being; CESC cis rs2857078 0.772 rs4793086 chr17:42320751 C/T cg19774624 chr17:42201019 HDAC5 0.54 7.16 0.4 7.85e-12 Red cell distribution width;Reticulocyte count; CESC cis rs2228479 0.850 rs1800355 chr16:89813194 C/T cg06558623 chr16:89946397 TCF25 1.15 9.14 0.49 1.65e-17 Skin colour saturation; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14799209 chr7:106809543 HBP1 0.45 6.12 0.35 3.35e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg12311346 chr5:56204834 C5orf35 -0.71 -8.71 -0.47 3.27e-16 Initial pursuit acceleration; CESC cis rs3008870 0.755 rs1121824 chr1:67475616 C/A cg02640540 chr1:67518911 SLC35D1 0.45 5.43 0.32 1.25e-7 Lymphocyte percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22599477 chr4:25507245 NA 0.47 6.03 0.35 5.51e-9 Fibrinogen levels; CESC cis rs6460942 0.597 rs13221702 chr7:12519076 A/G cg20607287 chr7:12443886 VWDE 0.68 7.42 0.41 1.58e-12 Coronary artery disease; CESC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg16325326 chr1:53192061 ZYG11B 0.89 15.2 0.68 5.86e-38 Monocyte count; CESC trans rs17508449 0.819 rs75290614 chr1:114242872 C/T cg23028848 chr11:57092561 TNKS1BP1 -0.81 -6.39 -0.37 7.62e-10 Leprosy; CESC cis rs7017914 0.967 rs6472538 chr8:71586971 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.09 -0.3 6.93e-7 Bone mineral density; CESC cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg02487422 chr3:49467188 NICN1 0.43 5.48 0.32 9.68e-8 Parkinson's disease; CESC cis rs7917772 0.636 rs2249850 chr10:104512006 A/G cg04362960 chr10:104952993 NT5C2 -0.49 -5.57 -0.32 6.4e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs11112613 0.762 rs17037312 chr12:105950085 C/T cg03607813 chr12:105948248 NA 0.68 8.4 0.46 2.82e-15 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs7584330 0.518 rs74003105 chr2:238446851 T/C cg14458575 chr2:238380390 NA 0.67 6.29 0.36 1.3e-9 Prostate cancer; CESC cis rs4561483 0.832 rs171656 chr16:11953167 C/T cg08843971 chr16:11963173 GSPT1 -0.56 -8.06 -0.44 2.56e-14 Testicular germ cell tumor; CESC cis rs873946 0.564 rs2803992 chr10:134550882 T/C cg26818010 chr10:134567672 INPP5A -0.76 -9.44 -0.5 2.02e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs12155623 0.619 rs870397 chr8:49861225 C/T cg22283653 chr8:49824208 NA 0.35 5.11 0.3 6.31e-7 Sudden cardiac arrest; CESC cis rs6480314 0.764 rs2394462 chr10:69981743 A/G cg06988349 chr10:69991859 ATOH7 -0.33 -5.21 -0.3 3.8e-7 Optic nerve measurement (disc area); CESC cis rs11718455 0.960 rs35869565 chr3:44002394 G/C cg08738300 chr3:44038990 NA 0.46 6.15 0.35 2.8e-9 Coronary artery disease; CESC cis rs56235845 0.694 rs11949401 chr5:176765989 A/G cg06060754 chr5:176797920 RGS14 0.42 5.26 0.31 2.91e-7 Hemoglobin concentration;Hematocrit; CESC cis rs12220238 1.000 rs10824102 chr10:75948915 C/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.09 0.3 6.71e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg18765753 chr7:1198926 ZFAND2A -0.47 -6.85 -0.39 5.15e-11 Longevity;Endometriosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13884470 chr9:86595151 HNRNPK;RMI1 -0.47 -6.57 -0.37 2.69e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11676348 0.818 rs6436033 chr2:218983763 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.46 -5.98 -0.34 7.31e-9 Ulcerative colitis; CESC cis rs9916302 0.904 rs7210488 chr17:37539819 T/G cg00129232 chr17:37814104 STARD3 0.57 7.41 0.41 1.71e-12 Glomerular filtration rate (creatinine); CESC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg17628894 chr11:804452 LRDD 0.3 6.03 0.35 5.62e-9 Breast cancer; CESC cis rs807669 0.903 rs807666 chr22:19160549 C/T cg02655711 chr22:19163373 SLC25A1 0.98 14.85 0.67 1e-36 Metabolite levels; CESC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg22508957 chr16:3507546 NAT15 -0.67 -7.27 -0.41 3.98e-12 Tuberculosis; CESC cis rs9815354 1.000 rs1607908 chr3:41905196 T/G cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs1707322 0.650 rs4660879 chr1:46105401 C/A cg03146154 chr1:46216737 IPP 0.76 10.71 0.55 1.75e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01961018 chr14:67999752 PLEKHH1 -0.42 -6.3 -0.36 1.26e-9 Gambling; CESC cis rs6460942 0.659 rs13247187 chr7:12551851 T/C cg20607287 chr7:12443886 VWDE -0.7 -7.64 -0.42 3.99e-13 Coronary artery disease; CESC cis rs1707322 0.752 rs28719889 chr1:46202283 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.2 0.4 6.2e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs367615 0.680 rs2256556 chr5:108964907 C/T cg17395555 chr5:108820864 NA -0.43 -6.17 -0.35 2.61e-9 Colorectal cancer (SNP x SNP interaction); CESC cis rs10754283 0.756 rs17441836 chr1:90135433 C/T cg21401794 chr1:90099060 LRRC8C 0.64 8.16 0.45 1.36e-14 Amyotrophic lateral sclerosis (sporadic); CESC cis rs593982 0.843 rs552312 chr11:65477349 C/T cg08755490 chr11:65554678 OVOL1 1.17 10.74 0.55 1.45e-22 Atopic dermatitis; CESC trans rs60843830 1.000 rs3828165 chr2:220889 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 8.02 0.44 3.32e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1801251 0.963 rs6739638 chr2:233576015 G/A cg25237894 chr2:233734115 C2orf82 0.5 8.5 0.46 1.39e-15 Coronary artery disease; CESC cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.36 5.17 0.3 4.59e-7 Schizophrenia; CESC cis rs636291 0.510 rs1307487 chr1:10506667 G/A cg07384165 chr1:10488281 NA -0.58 -8.62 -0.47 6.39e-16 Prostate cancer; CESC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg18876405 chr7:65276391 NA -0.53 -7.25 -0.41 4.64e-12 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17267720 chr15:34396248 PGBD4 -0.62 -7.98 -0.44 4.4e-14 Gut microbiome composition (summer); CESC cis rs9911578 1.000 rs12936058 chr17:57017420 T/C cg12560992 chr17:57184187 TRIM37 0.93 15.33 0.69 2.06e-38 Intelligence (multi-trait analysis); CESC trans rs1994135 0.630 rs11052760 chr12:33724949 A/T cg26384229 chr12:38710491 ALG10B 0.58 7.82 0.43 1.26e-13 Resting heart rate; CESC cis rs56775891 0.959 rs11663602 chr18:77578191 G/T cg13263691 chr18:77568018 NA 0.45 6.82 0.39 6.14e-11 Schizophrenia; CESC cis rs155076 1.000 rs261427 chr13:21860998 G/A cg11317459 chr13:21872234 NA -1.08 -12.18 -0.6 2.06e-27 White matter hyperintensity burden; CESC cis rs6499255 0.951 rs78772829 chr16:69607098 G/A cg15192750 chr16:69999425 NA 0.49 5.72 0.33 2.8e-8 IgE levels; CESC cis rs412050 0.501 rs78329092 chr22:22126203 C/T cg17089214 chr22:22089827 YPEL1 0.65 5.29 0.31 2.53e-7 Attention deficit hyperactivity disorder; CESC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg23048001 chr7:2026167 MAD1L1 0.45 5.88 0.34 1.22e-8 Bipolar disorder and schizophrenia; CESC cis rs8005677 0.926 rs34344888 chr14:23387585 A/G cg01529538 chr14:23388837 RBM23 0.51 6.87 0.39 4.64e-11 Cognitive ability (multi-trait analysis); CESC cis rs2425143 0.643 rs6058324 chr20:34388789 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.93 0.34 9.19e-9 Blood protein levels; CESC cis rs7193541 0.684 rs4888264 chr16:74681632 T/G cg01733217 chr16:74700730 RFWD3 1.05 20.24 0.78 1.09e-55 Multiple myeloma; CESC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg15352829 chr14:105391018 PLD4 -0.59 -10.35 -0.54 2.66e-21 Rheumatoid arthritis; CESC cis rs7786877 0.500 rs2272572 chr7:100285888 C/T cg16850897 chr7:100343110 ZAN -0.71 -8.68 -0.47 4.13e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs16866061 1.000 rs12470077 chr2:225334971 T/C cg12698349 chr2:225449008 CUL3 0.71 10.61 0.55 3.75e-22 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs2288073 0.965 rs13387930 chr2:24414400 A/G cg06627628 chr2:24431161 ITSN2 -0.8 -9.85 -0.52 1.03e-19 Venous thromboembolism (SNP x SNP interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02457282 chr5:121297575 SRFBP1 -0.53 -6.8 -0.39 6.74e-11 Fibrinogen levels; CESC trans rs17211056 0.744 rs2584281 chr18:73347313 C/T cg05934483 chr2:156763934 NA -0.65 -6.23 -0.36 1.78e-9 Serum uric acid levels in response to allopurinol in gout; CESC cis rs6502050 0.805 rs4356529 chr17:80157797 A/G cg23985595 chr17:80112537 CCDC57 0.39 6.24 0.36 1.72e-9 Life satisfaction; CESC cis rs2011503 1.000 rs2965184 chr19:19545428 C/T cg11584989 chr19:19387371 SF4 -0.61 -7.28 -0.41 3.87e-12 Bipolar disorder; CESC cis rs4718428 0.672 rs36038499 chr7:66289615 A/G cg12165864 chr7:66369176 NA -0.64 -7.19 -0.4 6.43e-12 Corneal structure; CESC cis rs896854 0.738 rs481887 chr8:95967838 A/G cg16049864 chr8:95962084 TP53INP1 0.63 9.79 0.52 1.67e-19 Type 2 diabetes; CESC cis rs7772486 0.754 rs4360151 chr6:146255079 A/C cg23711669 chr6:146136114 FBXO30 -0.81 -11.61 -0.58 1.87e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs4253772 0.513 rs6008612 chr22:46707907 G/A cg09491104 chr22:46646882 C22orf40 -0.62 -9.1 -0.49 2.17e-17 LDL cholesterol;Cholesterol, total; CESC cis rs9796 0.689 rs692153 chr15:41452681 C/T cg18705301 chr15:41695430 NDUFAF1 -0.48 -7.13 -0.4 9.77e-12 Menopause (age at onset); CESC cis rs2295359 1.000 rs10889661 chr1:67625309 T/A cg17031739 chr1:67600172 NA 0.4 5.23 0.31 3.44e-7 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21153026 chr5:130599493 CDC42SE2 0.57 6.3 0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg00934597 chr7:893267 UNC84A 0.53 5.34 0.31 2.03e-7 Cerebrospinal P-tau181p levels; CESC cis rs2688608 0.592 rs10762559 chr10:75486453 G/C cg23231163 chr10:75533350 FUT11 -0.36 -5.42 -0.32 1.33e-7 Inflammatory bowel disease; CESC cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg06697600 chr4:7070879 GRPEL1 0.48 7.4 0.41 1.84e-12 Monocyte percentage of white cells; CESC trans rs3942852 0.955 rs1910364 chr11:48113232 A/G cg03929089 chr4:120376271 NA -0.56 -6.02 -0.35 5.85e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg16680214 chr1:154839983 KCNN3 -0.44 -6.69 -0.38 1.28e-10 Prostate cancer; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg18827097 chr2:3522506 ADI1 0.49 6.45 0.37 5.42e-10 Obesity-related traits; CESC cis rs9611565 0.592 rs1811113 chr22:42073134 C/T cg03806693 chr22:41940476 POLR3H 1.09 12.68 0.61 4.09e-29 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17548431 chr4:160024475 NA 0.65 7.74 0.43 2.1e-13 Gut microbiome composition (summer); CESC cis rs4654899 0.965 rs17418249 chr1:21390582 C/T cg05370193 chr1:21551575 ECE1 0.39 5.85 0.34 1.45e-8 Superior frontal gyrus grey matter volume; CESC cis rs28595532 0.702 rs56217716 chr4:119338490 T/G cg21605333 chr4:119757512 SEC24D 1.01 5.58 0.32 5.98e-8 Cannabis dependence symptom count; CESC cis rs7772486 0.875 rs9376975 chr6:146355581 T/G cg23711669 chr6:146136114 FBXO30 0.85 12.46 0.61 2.27e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs589448 0.934 rs554591 chr12:69753847 T/C cg20891283 chr12:69753455 YEATS4 1.0 17.27 0.73 2.72e-45 Cerebrospinal fluid biomarker levels; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg08286599 chr2:191208694 INPP1 0.6 6.04 0.35 5.31e-9 Diastolic blood pressure; CESC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg12648201 chr2:27665141 KRTCAP3 -0.33 -6.22 -0.36 1.93e-9 Total body bone mineral density; CESC cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg22431228 chr1:16359049 CLCNKA -0.49 -8.15 -0.45 1.45e-14 Dilated cardiomyopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21451265 chr1:97187319 PTBP2 0.54 6.49 0.37 4.26e-10 Gut microbiome composition (summer); CESC cis rs1348850 0.914 rs7591807 chr2:178252986 A/G cg23306229 chr2:178417860 TTC30B 0.64 8.07 0.44 2.52e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs718433 0.584 rs7160973 chr14:22216675 C/A cg02257791 chr14:22217085 NA -0.32 -5.08 -0.3 7.19e-7 Intraocular pressure; CESC cis rs1451375 0.583 rs3807555 chr7:50610569 A/G cg14593290 chr7:50529359 DDC 0.49 5.95 0.34 8.34e-9 Malaria; CESC cis rs1879734 0.731 rs72660654 chr1:54157287 C/T cg23596471 chr1:54105337 GLIS1 0.34 5.6 0.33 5.27e-8 Mitral valve prolapse; CESC cis rs7587476 0.682 rs13009646 chr2:215691259 T/A cg04004882 chr2:215674386 BARD1 0.53 5.91 0.34 1.05e-8 Neuroblastoma; CESC cis rs7937682 0.924 rs6589244 chr11:111534333 T/C cg09085632 chr11:111637200 PPP2R1B -1.01 -16.19 -0.71 1.91e-41 Primary sclerosing cholangitis; CESC cis rs950169 0.922 rs4338765 chr15:84916836 G/T cg17507749 chr15:85114479 UBE2QP1 0.57 6.29 0.36 1.28e-9 Schizophrenia; CESC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg18876405 chr7:65276391 NA -0.45 -6.21 -0.36 2e-9 Aortic root size; CESC cis rs11098499 0.954 rs9998585 chr4:120396802 T/A cg24375607 chr4:120327624 NA 0.45 5.67 0.33 3.64e-8 Corneal astigmatism; CESC cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg20607287 chr7:12443886 VWDE -0.74 -8.74 -0.47 2.77e-16 Coronary artery disease; CESC cis rs2243480 1.000 rs316304 chr7:65616894 T/C cg12463550 chr7:65579703 CRCP 0.74 5.76 0.33 2.34e-8 Diabetic kidney disease; CESC trans rs1814175 0.645 rs28441045 chr11:50048971 C/T cg03929089 chr4:120376271 NA -0.91 -14.82 -0.67 1.29e-36 Height; CESC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg12288994 chr5:1860383 NA 0.39 6.63 0.38 1.84e-10 Cardiovascular disease risk factors; CESC trans rs9937837 1.000 rs9937837 chr16:31298939 A/C cg04903759 chr3:167238645 WDR49 0.49 6.07 0.35 4.3e-9 Systemic lupus erythematosus; CESC cis rs3741151 0.773 rs73544710 chr11:73162273 A/G cg17517138 chr11:73019481 ARHGEF17 1.0 7.41 0.41 1.74e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs10911251 0.546 rs3768625 chr1:183078712 G/T ch.1.3577855R chr1:183094577 LAMC1 0.86 13.75 0.65 7.63e-33 Colorectal cancer; CESC cis rs9300255 0.602 rs1402274 chr12:123686224 T/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.4 -0.37 6.92e-10 Neutrophil percentage of white cells; CESC cis rs3780486 0.846 rs6476399 chr9:33123013 A/G cg13443165 chr9:33130375 B4GALT1 0.45 6.46 0.37 4.92e-10 IgG glycosylation; CESC cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg17366294 chr4:99064904 C4orf37 0.54 7.18 0.4 7.09e-12 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01509141 chr13:44453359 CCDC122;C13orf31 -0.44 -6.31 -0.36 1.16e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.546 rs1456207 chr4:98676911 G/A cg17366294 chr4:99064904 C4orf37 0.48 5.84 0.34 1.52e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg03351412 chr1:154909251 PMVK -0.54 -7.11 -0.4 1.07e-11 Prostate cancer; CESC cis rs2289328 1.000 rs2289328 chr15:40705417 G/A cg13931752 chr15:40660718 DISP2 0.45 5.22 0.31 3.68e-7 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); CESC cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg20476274 chr7:133979776 SLC35B4 0.63 8.77 0.47 2.15e-16 Mean platelet volume; CESC cis rs2731664 0.792 rs335432 chr5:176866258 G/A cg23176889 chr5:176863531 GRK6 -0.64 -10.93 -0.56 3.27e-23 Intelligence (multi-trait analysis); CESC trans rs16949788 1.000 rs75532475 chr15:66832466 A/G cg08302325 chr6:106551827 PRDM1 0.68 6.09 0.35 3.95e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg25036284 chr2:26402008 FAM59B -0.61 -6.94 -0.39 3.06e-11 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg11663144 chr21:46675770 NA -0.61 -9.57 -0.51 8e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg05368731 chr17:41323189 NBR1 -0.59 -8.23 -0.45 8.35e-15 Menopause (age at onset); CESC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg17724175 chr1:150552817 MCL1 0.42 6.48 0.37 4.47e-10 Melanoma; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg04321497 chr2:179391695 TTN;MIR548N 0.41 6.15 0.35 2.86e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7656342 0.686 rs6822889 chr4:9826757 C/T cg00071950 chr4:10020882 SLC2A9 0.36 5.05 0.3 8.21e-7 Gut microbiota (bacterial taxa); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03130149 chr11:3819041 PGAP2;NUP98 0.48 6.35 0.36 9.37e-10 Gut microbiota (bacterial taxa); CESC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs1801251 0.778 rs778338 chr2:233740227 A/G cg08000102 chr2:233561755 GIGYF2 -0.6 -8.07 -0.44 2.43e-14 Coronary artery disease; CESC cis rs2637266 0.653 rs846614 chr10:78549265 A/C cg18941641 chr10:78392320 NA 0.39 7.43 0.41 1.54e-12 Pulmonary function; CESC cis rs12477438 0.798 rs4850891 chr2:99574642 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.51 -0.54 7.92e-22 Chronic sinus infection; CESC cis rs1348850 0.872 rs13004955 chr2:178398923 A/T cg23306229 chr2:178417860 TTC30B -0.61 -7.34 -0.41 2.62e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10489525 0.583 rs6691374 chr1:115642818 T/C cg01522456 chr1:115632236 TSPAN2 0.64 7.44 0.42 1.4e-12 Autism; CESC cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg11752832 chr7:134001865 SLC35B4 0.54 7.02 0.4 1.88e-11 Mean platelet volume; CESC cis rs7914558 0.966 rs7908280 chr10:104816947 C/G cg04362960 chr10:104952993 NT5C2 0.47 6.3 0.36 1.23e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs524281 0.861 rs10896091 chr11:65950825 T/C cg14036092 chr11:66035641 RAB1B -0.56 -5.57 -0.32 6.24e-8 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24002010 chr19:55741862 TMEM86B;SAPS1 -0.54 -6.13 -0.35 3.16e-9 Gut microbiome composition (summer); CESC cis rs1256061 0.646 rs1256059 chr14:64710417 A/G cg23250157 chr14:64679961 SYNE2 0.5 7.32 0.41 2.92e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15702823 chr6:10838819 NA 0.58 6.31 0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.37 -0.31 1.76e-7 Life satisfaction; CESC cis rs9443645 0.527 rs9359362 chr6:79723756 T/C cg05283184 chr6:79620031 NA -0.38 -5.51 -0.32 8.57e-8 Intelligence (multi-trait analysis); CESC cis rs2236918 1.000 rs1627006 chr1:242038004 C/T cg17736920 chr1:242011382 EXO1 0.68 9.02 0.48 3.89e-17 Menopause (age at onset); CESC cis rs123509 0.913 rs121993 chr3:42776601 T/C cg12982090 chr3:42733453 KBTBD5 0.7 8.44 0.46 2.1e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 10.05 0.53 2.43e-20 Alzheimer's disease; CESC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg11764359 chr7:65958608 NA -0.92 -14.69 -0.67 3.83e-36 Aortic root size; CESC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg23803603 chr1:2058230 PRKCZ -0.36 -6.58 -0.37 2.55e-10 Height; CESC cis rs3857067 0.934 rs2865336 chr4:95029357 G/A cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.61 -0.42 4.77e-13 QT interval; CESC cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg17366294 chr4:99064904 C4orf37 0.58 8.3 0.45 5.45e-15 Colonoscopy-negative controls vs population controls; CESC cis rs10876993 0.821 rs1629032 chr12:58038686 C/T cg18357645 chr12:58087776 OS9 0.59 9.08 0.49 2.55e-17 Celiac disease or Rheumatoid arthritis; CESC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 8.18 0.45 1.18e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2249625 0.844 rs2496515 chr6:72905741 C/T cg18830697 chr6:72922368 RIMS1 0.37 5.3 0.31 2.4e-7 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 12.92 0.62 6.11e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9486719 1.000 rs11153058 chr6:97012746 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -8.3 -0.45 5.39e-15 Migraine;Coronary artery disease; CESC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg25767906 chr1:53392781 SCP2 -0.52 -7.38 -0.41 2.05e-12 Monocyte count; CESC cis rs959260 1.000 rs4789180 chr17:73374396 G/T cg20590849 chr17:73267439 MIF4GD -0.58 -6.61 -0.38 2.14e-10 Systemic lupus erythematosus; CESC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg03806693 chr22:41940476 POLR3H 1.19 14.1 0.65 4.45e-34 Vitiligo; CESC cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg00825309 chr19:58991885 ZNF446 -0.58 -8.51 -0.46 1.34e-15 Uric acid clearance; CESC cis rs72781680 1.000 rs12616985 chr2:24165511 A/C cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg02951883 chr7:2050386 MAD1L1 -0.4 -5.31 -0.31 2.32e-7 Bipolar disorder and schizophrenia; CESC cis rs2404602 0.716 rs12438077 chr15:76863601 T/C cg22467129 chr15:76604101 ETFA -0.35 -5.24 -0.31 3.24e-7 Blood metabolite levels; CESC cis rs6009527 1.000 rs737834 chr22:49573190 C/T cg12746016 chr22:49560550 NA 0.34 5.2 0.3 4.03e-7 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); CESC trans rs3942852 0.568 rs1039484 chr11:48097948 A/G cg03929089 chr4:120376271 NA -0.63 -7.77 -0.43 1.71e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg21285383 chr16:89894308 SPIRE2 0.3 5.49 0.32 9.52e-8 Vitiligo; CESC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg03806693 chr22:41940476 POLR3H -1.2 -14.96 -0.68 4.1e-37 Vitiligo; CESC cis rs1371867 0.846 rs1788197 chr8:101290928 T/C cg11906718 chr8:101322791 RNF19A 0.43 5.45 0.32 1.17e-7 Atrioventricular conduction; CESC trans rs629535 0.773 rs655299 chr8:70074534 C/T cg21567404 chr3:27674614 NA 0.88 10.34 0.54 2.74e-21 Dupuytren's disease; CESC cis rs11792861 0.781 rs17729408 chr9:111740860 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.53 -6.76 -0.38 8.89e-11 Menarche (age at onset); CESC trans rs7726839 0.540 rs72707016 chr5:665148 A/G cg25482853 chr8:67687455 SGK3 0.97 9.73 0.51 2.43e-19 Obesity-related traits; CESC cis rs9527 0.641 rs34130454 chr10:104903638 A/G cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC trans rs2823962 0.759 rs2823930 chr21:18014269 G/A cg06419850 chr17:4688683 VMO1 -0.42 -6.08 -0.35 4.12e-9 Amyotrophic lateral sclerosis; CESC cis rs5758659 0.652 rs129857 chr22:42399686 C/T cg15557168 chr22:42548783 NA 0.44 6.54 0.37 3.24e-10 Cognitive function; CESC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -10.95 -0.56 2.97e-23 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17757281 chr20:44604666 NA -0.54 -6.88 -0.39 4.41e-11 Gut microbiome composition (summer); CESC cis rs9291683 0.609 rs55959894 chr4:10026580 G/A cg11266682 chr4:10021025 SLC2A9 0.7 14.15 0.66 3.01e-34 Bone mineral density; CESC trans rs6828577 0.819 rs298975 chr4:119636395 G/T cg05098011 chr1:151736092 OAZ3;MRPL9 0.48 6.03 0.35 5.43e-9 Perioperative myocardial infarction in coronary artery bypass surgery; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07016325 chr14:96968745 PAPOLA -0.48 -6.28 -0.36 1.4e-9 Gut microbiota (bacterial taxa); CESC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.87 13.73 0.64 9.48e-33 Prudent dietary pattern; CESC cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg05234568 chr11:5960015 NA -0.57 -6.76 -0.38 9e-11 DNA methylation (variation); CESC trans rs66573146 0.572 rs67750430 chr4:6957266 T/G cg07817883 chr1:32538562 TMEM39B 1.25 8.75 0.47 2.56e-16 Granulocyte percentage of myeloid white cells; CESC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -8.19 -0.45 1.09e-14 Developmental language disorder (linguistic errors); CESC cis rs5758659 1.000 rs5751255 chr22:42648408 C/T cg15557168 chr22:42548783 NA -0.51 -8.05 -0.44 2.87e-14 Cognitive function; CESC cis rs11098499 0.615 rs59867181 chr4:120556467 C/T cg09307838 chr4:120376055 NA -0.63 -8.23 -0.45 8.44e-15 Corneal astigmatism; CESC cis rs244293 0.673 rs12944690 chr17:53029614 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.42 -5.6 -0.33 5.26e-8 Menarche (age at onset); CESC cis rs2777491 0.957 rs2015781 chr15:41648967 C/G cg20272979 chr15:41787780 ITPKA 0.35 5.16 0.3 4.94e-7 Ulcerative colitis; CESC cis rs17253792 0.908 rs74354306 chr14:56065778 T/G cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC cis rs2228479 0.850 rs12598316 chr16:89916600 C/A cg06558623 chr16:89946397 TCF25 1.15 8.27 0.45 6.45e-15 Skin colour saturation; CESC cis rs7520050 0.966 rs4660319 chr1:46341623 C/T cg03146154 chr1:46216737 IPP -0.49 -6.37 -0.36 8.44e-10 Red blood cell count;Reticulocyte count; CESC cis rs1595825 0.838 rs80172713 chr2:198508044 T/C cg00982548 chr2:198649783 BOLL -0.48 -5.12 -0.3 5.91e-7 Ulcerative colitis; CESC cis rs8014204 0.816 rs10144023 chr14:75291531 T/C cg08847533 chr14:75593920 NEK9 0.41 5.32 0.31 2.19e-7 Caffeine consumption; CESC cis rs477692 0.563 rs12266634 chr10:131412659 G/C cg05714579 chr10:131428358 MGMT -0.73 -10.79 -0.55 9.88e-23 Response to temozolomide; CESC cis rs6598955 0.670 rs6663950 chr1:26560131 T/C cg04990556 chr1:26633338 UBXN11 -0.79 -11.53 -0.58 3.46e-25 Obesity-related traits; CESC cis rs1364705 1.000 rs1364705 chr8:120224806 C/T cg09273054 chr8:120220131 MAL2 -0.62 -7.31 -0.41 3.25e-12 Hippocampal atrophy; CESC cis rs2282802 0.685 rs4913079 chr5:139683029 A/G cg26211634 chr5:139558579 C5orf32 0.48 6.99 0.39 2.2e-11 Intelligence (multi-trait analysis); CESC cis rs1348850 0.632 rs10167783 chr2:178519041 G/A cg22681709 chr2:178499509 PDE11A -0.59 -8.97 -0.48 5.51e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs208520 1.000 rs12209225 chr6:66996443 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.83 9.05 0.49 3.13e-17 Exhaled nitric oxide output; CESC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg19099843 chr7:12443191 VWDE -0.5 -5.26 -0.31 2.97e-7 Coronary artery disease; CESC cis rs854765 0.547 rs4925135 chr17:17952868 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.33 -0.36 1.03e-9 Total body bone mineral density; CESC cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6087990 0.863 rs1569686 chr20:31367079 G/T cg13636640 chr20:31349939 DNMT3B 0.89 15.66 0.69 1.46e-39 Ulcerative colitis; CESC cis rs72627123 0.867 rs75754154 chr14:74473578 C/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.82 5.9 0.34 1.11e-8 Morning vs. evening chronotype; CESC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg04317338 chr11:64019027 PLCB3 0.54 6.4 0.37 7.17e-10 Platelet count; CESC cis rs6076065 0.707 rs2424555 chr20:23417705 A/G cg11657817 chr20:23433608 CST11 0.39 5.68 0.33 3.62e-8 Facial morphology (factor 15, philtrum width); CESC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg05564831 chr3:52568323 NT5DC2 0.48 7.67 0.43 3.21e-13 Bipolar disorder; CESC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg23034840 chr1:205782522 SLC41A1 0.73 9.57 0.51 7.98e-19 Prostate-specific antigen levels; CESC cis rs7726839 0.540 rs3762951 chr5:662613 C/G cg16447950 chr5:562315 NA -0.61 -6.66 -0.38 1.57e-10 Obesity-related traits; CESC cis rs796364 1.000 rs281774 chr2:200814572 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.9 8.98 0.48 5.3e-17 Schizophrenia; CESC cis rs6964587 1.000 rs12666179 chr7:91574110 T/C cg17063962 chr7:91808500 NA -0.57 -7.69 -0.43 2.84e-13 Breast cancer; CESC cis rs2249694 0.959 rs4129223 chr10:135403948 A/G cg19469447 chr10:135341870 CYP2E1 0.36 5.11 0.3 6.24e-7 Obesity-related traits; CESC cis rs4654899 0.680 rs4233274 chr1:21121678 C/T cg05370193 chr1:21551575 ECE1 0.35 5.25 0.31 3.15e-7 Superior frontal gyrus grey matter volume; CESC cis rs113835537 0.529 rs75003264 chr11:66256099 G/A cg22134325 chr11:66188745 NPAS4 0.46 7.03 0.4 1.78e-11 Airway imaging phenotypes; CESC cis rs8170 0.603 rs4808621 chr19:17414267 C/T cg04749549 chr19:17459798 NA -0.33 -5.33 -0.31 2.15e-7 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CESC cis rs76878669 0.538 rs1785633 chr11:66107527 C/A cg18002602 chr11:66138449 SLC29A2 0.41 6.75 0.38 9.45e-11 Educational attainment (years of education); CESC cis rs965469 0.947 rs965468 chr20:3381443 C/T cg25506879 chr20:3388711 C20orf194 -0.58 -6.09 -0.35 3.93e-9 IFN-related cytopenia; CESC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.49 6.99 0.39 2.23e-11 Bipolar disorder; CESC cis rs13253111 0.624 rs28372101 chr8:28099384 G/T cg26534493 chr8:28060551 NA 0.46 7.29 0.41 3.66e-12 Childhood body mass index; CESC cis rs7219021 0.770 rs7217007 chr17:46844697 C/T cg16584676 chr17:46985605 UBE2Z 0.45 5.47 0.32 1.06e-7 Schizophrenia or bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19460713 chr2:201170819 SPATS2L -0.43 -6.06 -0.35 4.65e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7726839 0.718 rs6887972 chr5:597274 C/G cg09021430 chr5:549028 NA -0.44 -6.14 -0.35 3.06e-9 Obesity-related traits; CESC trans rs853679 0.556 rs34588114 chr6:28080628 C/A cg01620082 chr3:125678407 NA -0.81 -6.34 -0.36 1.01e-9 Depression; CESC cis rs7605827 0.930 rs3755129 chr2:15523549 T/C cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs6977660 0.507 rs4721822 chr7:19771693 T/C cg05791153 chr7:19748676 TWISTNB 0.76 6.91 0.39 3.51e-11 Thyroid stimulating hormone; CESC cis rs2239547 0.522 rs9311485 chr3:52987645 T/G cg11645453 chr3:52864694 ITIH4 -0.32 -5.37 -0.31 1.69e-7 Schizophrenia; CESC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg00149659 chr3:10157352 C3orf10 0.73 8.89 0.48 9.97e-17 Alzheimer's disease; CESC cis rs4319547 1.000 rs9705654 chr12:123083508 T/C cg05707623 chr12:122985044 ZCCHC8 -0.55 -6.53 -0.37 3.33e-10 Body mass index; CESC cis rs5753618 0.504 rs9609329 chr22:31966313 A/C cg02404636 chr22:31891804 SFI1 0.45 6.09 0.35 3.97e-9 Colorectal cancer; CESC cis rs3126085 0.935 rs10888466 chr1:152166223 A/C cg03465714 chr1:152285911 FLG 0.44 5.42 0.32 1.35e-7 Atopic dermatitis; CESC trans rs11039798 0.588 rs6485857 chr11:48556511 C/A cg03929089 chr4:120376271 NA 0.62 6.07 0.35 4.44e-9 Axial length; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg26879696 chr10:114206778 VTI1A;ZDHHC6 0.53 7.01 0.4 1.95e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg05564831 chr3:52568323 NT5DC2 0.44 6.83 0.39 5.67e-11 Bipolar disorder; CESC cis rs6942756 0.806 rs6967464 chr7:128909727 T/C cg02491457 chr7:128862824 NA 0.64 9.27 0.49 6.86e-18 White matter hyperintensity burden; CESC cis rs10751667 0.643 rs10902234 chr11:935578 A/G cg06064525 chr11:970664 AP2A2 -0.5 -9.97 -0.52 4.29e-20 Alzheimer's disease (late onset); CESC cis rs2742234 0.915 rs2742233 chr10:43610558 C/T cg15436174 chr10:43711423 RASGEF1A -0.41 -5.07 -0.3 7.38e-7 Hirschsprung disease; CESC cis rs708547 0.874 rs1713978 chr4:57875879 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.52 -5.54 -0.32 7.27e-8 Response to bleomycin (chromatid breaks); CESC cis rs4253772 0.638 rs6007845 chr22:46718417 A/T cg09491104 chr22:46646882 C22orf40 0.54 8.27 0.45 6.76e-15 LDL cholesterol;Cholesterol, total; CESC cis rs698833 1.000 rs698833 chr2:44735438 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.44 5.09 0.3 6.87e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23695184 chr11:1316916 TOLLIP -0.55 -6.13 -0.35 3.16e-9 Gut microbiome composition (summer); CESC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg19592336 chr6:28129416 ZNF389 0.51 7.03 0.4 1.73e-11 Depression; CESC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg07395648 chr5:131743802 NA -0.41 -5.19 -0.3 4.24e-7 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03817476 chr2:201727403 CLK1 -0.43 -6.13 -0.35 3.11e-9 Gambling; CESC cis rs57506017 0.585 rs1060700 chr7:12275818 A/G cg23422036 chr7:12250390 TMEM106B 0.39 5.24 0.31 3.35e-7 Neuroticism; CESC cis rs11792861 0.555 rs4978767 chr9:111762925 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.64 9.74 0.51 2.26e-19 Menarche (age at onset); CESC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg18904891 chr8:8559673 CLDN23 0.69 8.05 0.44 2.89e-14 Obesity-related traits; CESC cis rs3733585 0.699 rs7658170 chr4:9966593 C/T cg00071950 chr4:10020882 SLC2A9 0.67 10.86 0.56 5.61e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs909002 0.886 rs11807225 chr1:32083193 G/C cg13919466 chr1:32135498 COL16A1 -0.47 -8.28 -0.45 6.11e-15 Intelligence (multi-trait analysis); CESC trans rs7615952 0.599 rs6766327 chr3:125723677 C/G cg07211511 chr3:129823064 LOC729375 -0.54 -6.22 -0.36 1.97e-9 Blood pressure (smoking interaction); CESC cis rs10489525 0.583 rs12034918 chr1:115626285 C/T cg01522456 chr1:115632236 TSPAN2 0.6 6.95 0.39 2.82e-11 Autism; CESC cis rs10791097 0.739 rs12279359 chr11:130730544 G/A cg09137382 chr11:130731461 NA 0.39 5.86 0.34 1.36e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg11941060 chr3:133502564 NA -0.53 -7.01 -0.4 1.95e-11 Iron status biomarkers; CESC cis rs12738007 0.544 rs12408688 chr1:29431072 C/T cg01925633 chr1:29338769 EPB41 0.35 5.03 0.3 9.04e-7 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01161919 chr16:30750542 SRCAP 0.44 6.18 0.35 2.45e-9 Fibrinogen levels; CESC cis rs9300255 0.537 rs1716182 chr12:123686127 A/C cg05973401 chr12:123451056 ABCB9 0.5 5.74 0.33 2.53e-8 Neutrophil percentage of white cells; CESC cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg25566285 chr7:158114605 PTPRN2 0.48 7.73 0.43 2.31e-13 Calcium levels; CESC cis rs2380220 0.576 rs4498363 chr6:96042338 A/C cg23517279 chr6:96025343 MANEA 0.54 5.28 0.31 2.74e-7 Behavioural disinhibition (generation interaction); CESC cis rs1499614 1.000 rs60326618 chr7:66166358 G/A cg13147721 chr7:65941812 NA -0.94 -8.9 -0.48 9.08e-17 Gout; CESC cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg06766960 chr11:133703094 NA -0.39 -5.6 -0.33 5.25e-8 Childhood ear infection; CESC cis rs6662572 0.737 rs11211206 chr1:46323192 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.04 -0.3 8.65e-7 Blood protein levels; CESC cis rs6690583 0.623 rs12030730 chr1:85454109 C/G cg22153463 chr1:85462885 MCOLN2 0.7 7.02 0.4 1.87e-11 Serum sulfate level; CESC trans rs12229918 0.540 rs10784460 chr12:65863584 C/T ch.2.195648145F chr2:195939902 NA 0.49 6.1 0.35 3.81e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CESC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg11843238 chr5:131593191 PDLIM4 0.36 5.24 0.31 3.32e-7 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11412766 chr2:55276306 RTN4 -0.4 -6.35 -0.36 9.23e-10 Gambling; CESC cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg01475377 chr6:109611718 NA -0.51 -8.56 -0.47 9.09e-16 Reticulocyte fraction of red cells; CESC cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg19077165 chr18:44547161 KATNAL2 -0.52 -7.65 -0.43 3.72e-13 Personality dimensions; CESC cis rs4253772 0.591 rs10854854 chr22:46684706 C/G cg10541313 chr22:46663664 TTC38 0.61 5.07 0.3 7.65e-7 LDL cholesterol;Cholesterol, total; CESC trans rs116095464 0.558 rs10060089 chr5:205565 G/A cg00938859 chr5:1591904 SDHAP3 0.66 6.26 0.36 1.55e-9 Breast cancer; CESC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg08736216 chr1:53307985 ZYG11A -0.38 -6.48 -0.37 4.45e-10 Monocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05927802 chr8:110346885 ENY2;NUDCD1 -0.38 -6.0 -0.35 6.6e-9 Gambling; CESC cis rs9457247 0.935 rs9348211 chr6:167375173 G/C cg25258033 chr6:167368657 RNASET2 -0.4 -6.11 -0.35 3.49e-9 Crohn's disease; CESC cis rs6570726 0.818 rs399516 chr6:145810849 C/A cg23711669 chr6:146136114 FBXO30 0.88 13.31 0.63 2.77e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs6785206 0.667 rs2253125 chr3:128329793 T/C cg16766828 chr3:128327626 NA -0.44 -5.13 -0.3 5.56e-7 Lymphocyte percentage of white cells; CESC cis rs5753618 0.561 rs1858821 chr22:31676454 T/C cg00478049 chr22:31556069 RNF185 0.46 5.21 0.3 3.75e-7 Colorectal cancer; CESC cis rs1348850 0.651 rs4893935 chr2:178240601 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.32 0.45 4.84e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03870845 chr17:52978014 TOM1L1 0.57 6.93 0.39 3.2e-11 Gut microbiome composition (summer); CESC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg05863683 chr7:1912471 MAD1L1 0.47 7.07 0.4 1.37e-11 Bipolar disorder and schizophrenia; CESC cis rs2836633 0.965 rs2836621 chr21:40054149 C/T cg12884169 chr21:40033163 ERG 0.36 5.79 0.34 1.95e-8 Coronary artery disease; CESC cis rs78456975 0.941 rs13423300 chr2:1553809 C/A cg01028140 chr2:1542097 TPO -0.5 -5.26 -0.31 3.03e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs863345 0.504 rs857698 chr1:158561166 A/T cg12129480 chr1:158549410 OR10X1 -0.3 -5.58 -0.32 6.04e-8 Pneumococcal bacteremia; CESC cis rs7605827 0.930 rs1990753 chr2:15612403 G/C cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs9611519 0.589 rs8138917 chr22:41412425 T/C cg03806693 chr22:41940476 POLR3H -0.51 -6.04 -0.35 5.11e-9 Neuroticism; CESC cis rs3096299 0.746 rs9931120 chr16:89501357 A/G cg08822215 chr16:89438651 ANKRD11 -0.36 -5.31 -0.31 2.34e-7 Multiple myeloma (IgH translocation); CESC cis rs1957429 0.614 rs73279833 chr14:65352523 A/G cg23373153 chr14:65346875 NA -0.92 -6.68 -0.38 1.43e-10 Pediatric areal bone mineral density (radius); CESC cis rs17253792 0.822 rs74653073 chr14:56079528 T/C cg01858014 chr14:56050164 KTN1 -0.93 -7.29 -0.41 3.53e-12 Putamen volume; CESC cis rs7336332 0.662 rs9581862 chr13:28039993 T/G cg22138327 chr13:27999177 GTF3A 0.64 7.1 0.4 1.16e-11 Weight; CESC cis rs9487051 0.768 rs2483913 chr6:109521042 G/A cg01475377 chr6:109611718 NA -0.46 -6.93 -0.39 3.18e-11 Reticulocyte fraction of red cells; CESC cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.56 0.32 6.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11190604 1.000 rs10883499 chr10:102232188 T/A cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs10242455 0.702 rs73403247 chr7:99088730 G/A cg09045935 chr12:6379348 NA 0.89 7.38 0.41 2.01e-12 Blood metabolite levels; CESC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg21963583 chr11:68658836 MRPL21 0.38 5.47 0.32 1.03e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.96 0.34 8.05e-9 Tonsillectomy; CESC cis rs3733585 0.673 rs4519796 chr4:9955936 A/G cg02734326 chr4:10020555 SLC2A9 -0.4 -5.77 -0.33 2.19e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs796364 0.906 rs1658810 chr2:200816382 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.91 9.08 0.49 2.59e-17 Schizophrenia; CESC cis rs13082711 0.911 rs17019721 chr3:27424799 A/G cg02860705 chr3:27208620 NA 0.52 6.53 0.37 3.36e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs9467711 0.606 rs12174602 chr6:26372827 C/T cg14345882 chr6:26364793 BTN3A2 0.59 6.07 0.35 4.33e-9 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03069383 chr2:18741691 RDH14 0.57 6.61 0.38 2.16e-10 Gut microbiome composition (summer); CESC cis rs4481887 0.927 rs4537599 chr1:248508741 G/A cg00666640 chr1:248458726 OR2T12 0.41 6.62 0.38 1.97e-10 Common traits (Other); CESC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.94 0.34 8.83e-9 Tonsillectomy; CESC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg06873352 chr17:61820015 STRADA 0.47 6.77 0.38 8.31e-11 Height; CESC trans rs11098499 0.954 rs28429722 chr4:120300093 G/A cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs7202877 0.610 rs3844219 chr16:75370230 G/T cg04384234 chr16:75411784 CFDP1 -0.47 -5.57 -0.32 6.39e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs4704187 0.687 rs9918293 chr5:74514828 T/C cg03227963 chr5:74354835 NA 0.28 5.13 0.3 5.48e-7 Response to amphetamines; CESC cis rs6714710 0.603 rs12988571 chr2:98405695 C/T cg26665480 chr2:98280029 ACTR1B 0.59 8.24 0.45 7.8e-15 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs4955124 0.558 rs4502621 chr3:32019900 C/G cg05935571 chr3:32023257 ZNF860;OSBPL10 0.94 8.49 0.46 1.54e-15 Schizophrenia; CESC cis rs137603 0.502 rs137627 chr22:39716341 G/A cg01093212 chr22:39715156 SNORD43;RPL3 -0.42 -5.45 -0.32 1.15e-7 Primary biliary cholangitis; CESC trans rs11039798 0.920 rs116109043 chr11:48976940 C/T cg15704280 chr7:45808275 SEPT13 0.7 6.56 0.37 2.74e-10 Axial length; CESC cis rs3780486 0.813 rs3780488 chr9:33133812 T/C cg13443165 chr9:33130375 B4GALT1 0.46 6.59 0.38 2.3e-10 IgG glycosylation; CESC cis rs763014 0.931 rs7199839 chr16:636126 T/C cg00908189 chr16:619842 PIGQ 0.65 9.02 0.48 4.04e-17 Height; CESC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.87 12.78 0.62 1.9e-29 Prudent dietary pattern; CESC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg01416388 chr22:39784598 NA -0.57 -7.42 -0.41 1.62e-12 Intelligence (multi-trait analysis); CESC cis rs8133932 0.576 rs2839039 chr21:47321499 T/G cg14185626 chr21:47401492 COL6A1 0.46 5.11 0.3 6.08e-7 Schizophrenia; CESC cis rs7089973 0.604 rs11196952 chr10:116607592 G/A cg03647239 chr10:116582469 FAM160B1 0.43 5.35 0.31 1.94e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs597539 0.690 rs7129960 chr11:68622456 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 9.39 0.5 2.91e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.76e-18 Skin colour saturation; CESC cis rs7937682 0.889 rs521155 chr11:111492563 G/A cg22437258 chr11:111473054 SIK2 0.72 9.66 0.51 4.24e-19 Primary sclerosing cholangitis; CESC cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28830936 0.510 rs12440605 chr15:42102285 A/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 0.32 5.06 0.3 7.67e-7 Diastolic blood pressure; CESC cis rs6061231 1.000 rs67941642 chr20:60958108 C/T cg24112000 chr20:60950667 NA -0.56 -7.79 -0.43 1.52e-13 Colorectal cancer; CESC cis rs9581857 0.725 rs9319366 chr13:28017722 C/T cg22138327 chr13:27999177 GTF3A 0.65 5.22 0.31 3.6e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11588710 chr3:191670637 NA -0.56 -6.45 -0.37 5.32e-10 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg24549020 chr5:56110836 MAP3K1 0.68 7.72 0.43 2.37e-13 Initial pursuit acceleration; CESC cis rs6598955 0.515 rs61776655 chr1:26541430 T/C cg19743891 chr1:26644573 UBXN11;CD52 -0.27 -5.21 -0.31 3.73e-7 Obesity-related traits; CESC cis rs1018836 0.923 rs2213886 chr8:91554163 G/C cg16814680 chr8:91681699 NA -0.72 -10.63 -0.55 3.14e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs11098499 0.779 rs10011097 chr4:120310359 T/G cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs7586879 0.616 rs6545814 chr2:25131316 A/G cg01884057 chr2:25150051 NA 0.36 6.97 0.39 2.55e-11 Body mass index; CESC cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg12365402 chr11:9010492 NRIP3 -0.32 -5.07 -0.3 7.37e-7 Hemoglobin concentration; CESC cis rs5771225 0.505 rs2341111 chr22:50690322 G/C cg16473166 chr22:50639996 SELO 0.47 5.22 0.31 3.56e-7 Late-onset Alzheimer's disease; CESC cis rs17433780 0.897 rs12142922 chr1:89489915 A/G cg09516651 chr1:89888402 LOC400759 0.68 9.49 0.5 1.43e-18 Carotid intima media thickness; CESC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.08 0.44 2.29e-14 Colonoscopy-negative controls vs population controls; CESC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg21963583 chr11:68658836 MRPL21 0.4 5.52 0.32 8.06e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10489525 0.583 rs6660550 chr1:115650850 C/G cg01522456 chr1:115632236 TSPAN2 0.6 6.87 0.39 4.5e-11 Autism; CESC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg06456125 chr7:65229604 NA 0.44 5.75 0.33 2.47e-8 Aortic root size; CESC cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg18180107 chr4:99064573 C4orf37 0.39 5.13 0.3 5.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.74e-9 Prudent dietary pattern; CESC cis rs938554 0.784 rs11726102 chr4:9951664 T/C cg00071950 chr4:10020882 SLC2A9 -0.5 -5.82 -0.34 1.7e-8 Blood metabolite levels; CESC cis rs1538970 1.000 rs9326141 chr1:45828943 A/G cg05343316 chr1:45956843 TESK2 -0.83 -11.33 -0.57 1.53e-24 Platelet count; CESC trans rs208515 0.518 rs12209790 chr6:66662965 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 10.74 0.55 1.42e-22 Exhaled nitric oxide levels; CESC cis rs6460942 1.000 rs7792759 chr7:12311715 A/G cg10578991 chr7:12443926 VWDE 0.51 5.51 0.32 8.58e-8 Coronary artery disease; CESC cis rs208520 0.802 rs4710314 chr6:66883656 G/A cg07460842 chr6:66804631 NA -0.94 -12.15 -0.6 2.75e-27 Exhaled nitric oxide output; CESC cis rs3105593 1.000 rs3105593 chr15:50845018 C/T cg08437265 chr15:50716283 USP8 0.45 5.74 0.33 2.63e-8 QT interval; CESC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg08859206 chr1:53392774 SCP2 0.56 7.11 0.4 1.1e-11 Monocyte count; CESC cis rs2404602 0.692 rs60658665 chr15:77042508 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg11644478 chr21:40555479 PSMG1 -0.58 -7.17 -0.4 7.64e-12 Menarche (age at onset); CESC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg08109568 chr15:31115862 NA -0.68 -9.08 -0.49 2.54e-17 Huntington's disease progression; CESC cis rs9905704 0.718 rs1271647 chr17:56655872 G/C cg12560992 chr17:57184187 TRIM37 -0.64 -5.98 -0.34 7.36e-9 Testicular germ cell tumor; CESC cis rs7772486 0.686 rs857879 chr6:145974043 C/A cg23711669 chr6:146136114 FBXO30 -0.88 -13.04 -0.63 2.31e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs8017423 0.605 rs4904676 chr14:90819220 G/A cg14092571 chr14:90743983 NA 0.44 6.62 0.38 1.93e-10 Mortality in heart failure; CESC cis rs7605827 0.930 rs6759785 chr2:15529269 A/C cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs2073300 1.000 rs6137957 chr20:23437384 G/A cg12062639 chr20:23401060 NAPB 0.87 5.85 0.34 1.43e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9457247 0.967 rs2149092 chr6:167372978 C/T cg23791538 chr6:167370224 RNASET2 0.6 8.49 0.46 1.53e-15 Crohn's disease; CESC cis rs7605827 0.836 rs4396685 chr2:15634407 C/T cg19274914 chr2:15703543 NA 0.35 6.23 0.36 1.83e-9 Educational attainment (years of education); CESC trans rs877282 0.583 rs10904562 chr10:819058 T/C cg22713356 chr15:30763199 NA 1.06 9.67 0.51 3.87e-19 Uric acid levels; CESC cis rs897984 0.806 rs4889571 chr16:30949047 A/G cg02466173 chr16:30829666 NA 0.48 8.01 0.44 3.58e-14 Dementia with Lewy bodies; CESC cis rs10504073 0.584 rs55908480 chr8:49923431 G/A cg00325661 chr8:49890786 NA 0.53 7.95 0.44 5.42e-14 Blood metabolite ratios; CESC cis rs7937682 0.883 rs1789351 chr11:111456436 T/A cg09085632 chr11:111637200 PPP2R1B -0.93 -13.43 -0.64 1.06e-31 Primary sclerosing cholangitis; CESC cis rs2130392 1.000 rs4862406 chr4:185629339 G/A cg21366198 chr4:185655624 MLF1IP 0.43 6.06 0.35 4.64e-9 Kawasaki disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08352268 chr17:6947337 SLC16A11 -0.51 -6.18 -0.35 2.46e-9 Gut microbiome composition (summer); CESC cis rs17376456 0.825 rs17372615 chr5:93124768 C/T cg25358565 chr5:93447407 FAM172A 1.1 10.84 0.55 6.88e-23 Diabetic retinopathy; CESC cis rs7927771 0.524 rs11039345 chr11:47720228 A/G cg20307385 chr11:47447363 PSMC3 0.61 8.61 0.47 6.76e-16 Subjective well-being; CESC cis rs13385 0.769 rs10477333 chr5:139617885 T/C cg26211634 chr5:139558579 C5orf32 0.48 5.29 0.31 2.54e-7 Atrial fibrillation; CESC cis rs9467711 0.659 rs13220261 chr6:26499185 C/T cg14345882 chr6:26364793 BTN3A2 0.62 5.11 0.3 6.12e-7 Autism spectrum disorder or schizophrenia; CESC cis rs6142102 0.517 rs8119076 chr20:32525715 A/G cg08999081 chr20:33150536 PIGU 0.35 5.26 0.31 3.03e-7 Skin pigmentation; CESC cis rs2274273 0.773 rs8006525 chr14:55813394 T/G cg04306507 chr14:55594613 LGALS3 0.32 6.31 0.36 1.19e-9 Protein biomarker; CESC cis rs4906332 1.000 rs35366629 chr14:103903054 A/G cg09975044 chr14:104007538 NA 0.47 6.56 0.37 2.79e-10 Coronary artery disease; CESC cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg21573476 chr21:45109991 RRP1B -0.49 -6.79 -0.38 7.52e-11 Mean corpuscular volume; CESC cis rs6688613 0.765 rs56229522 chr1:166816108 T/A ch.1.3259774R chr1:166827647 TADA1 0.6 6.27 0.36 1.5e-9 Refractive astigmatism; CESC cis rs7937682 0.883 rs1789351 chr11:111456436 T/A cg22437258 chr11:111473054 SIK2 0.71 9.07 0.49 2.69e-17 Primary sclerosing cholangitis; CESC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.13 0.3 5.51e-7 Menopause (age at onset); CESC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg11764359 chr7:65958608 NA 0.96 15.03 0.68 2.41e-37 Aortic root size; CESC cis rs17253792 0.732 rs8017891 chr14:56172967 A/G cg24579896 chr14:56047964 C14orf33;KTN1 -0.69 -5.95 -0.34 8.65e-9 Putamen volume; CESC cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.78 0.62 1.89e-29 Personality dimensions; CESC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.41 -5.26 -0.31 2.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4474465 0.562 rs10793318 chr11:78215898 A/C cg27205649 chr11:78285834 NARS2 0.44 5.27 0.31 2.84e-7 Alzheimer's disease (survival time); CESC cis rs826838 1.000 rs11169031 chr12:39056738 T/C cg26384229 chr12:38710491 ALG10B 0.81 13.7 0.64 1.14e-32 Heart rate; CESC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.16 -0.35 2.62e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8016947 0.506 rs7157054 chr14:35785129 G/A cg16230307 chr14:35515116 FAM177A1 -0.42 -5.27 -0.31 2.77e-7 Psoriasis; CESC cis rs3820068 0.581 rs72645881 chr1:15928203 C/T cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.33 -0.31 2.07e-7 Lung cancer; CESC cis rs7824557 1.000 rs2736371 chr8:11105529 A/G cg21775007 chr8:11205619 TDH -0.38 -5.34 -0.31 1.96e-7 Retinal vascular caliber; CESC cis rs8077577 0.747 rs12449313 chr17:18221010 A/G cg16794390 chr17:18148240 FLII 0.4 6.34 0.36 9.98e-10 Obesity-related traits; CESC cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg11952622 chr19:58962976 ZNF324B 0.5 6.85 0.39 5.17e-11 Uric acid clearance; CESC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2637266 0.703 rs846579 chr10:78498535 G/C cg18941641 chr10:78392320 NA 0.39 7.5 0.42 9.94e-13 Pulmonary function; CESC cis rs6541297 0.941 rs6690424 chr1:230278892 C/T cg20703242 chr1:230279135 GALNT2 0.68 10.87 0.56 5.47e-23 Coronary artery disease; CESC cis rs9486719 0.947 rs12194971 chr6:96911073 T/C cg18709589 chr6:96969512 KIAA0776 -0.54 -5.97 -0.34 7.42e-9 Migraine;Coronary artery disease; CESC cis rs9649465 1.000 rs2109724 chr7:123325391 C/T cg04330084 chr7:123175371 IQUB -0.38 -5.22 -0.31 3.69e-7 Migraine; CESC cis rs9790314 0.905 rs7633186 chr3:161003124 A/G cg03342759 chr3:160939853 NMD3 -0.46 -6.12 -0.35 3.33e-9 Morning vs. evening chronotype; CESC cis rs7408868 0.908 rs1044006 chr19:15285052 T/C cg14696996 chr19:15285081 NOTCH3 1.09 11.5 0.58 4.26e-25 Pulse pressure; CESC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg11764359 chr7:65958608 NA 0.72 8.59 0.47 7.82e-16 Aortic root size; CESC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg22764044 chr5:178986830 RUFY1 -0.43 -6.2 -0.36 2.14e-9 Lung cancer; CESC cis rs35110281 0.837 rs7279958 chr21:45016016 C/A cg21573476 chr21:45109991 RRP1B -0.45 -6.37 -0.36 8.28e-10 Mean corpuscular volume; CESC cis rs7605827 0.930 rs6705287 chr2:15529368 A/C cg19274914 chr2:15703543 NA 0.37 6.74 0.38 9.98e-11 Educational attainment (years of education); CESC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg10494973 chr17:80897199 TBCD 0.5 5.73 0.33 2.65e-8 Breast cancer; CESC cis rs367615 0.959 rs4957830 chr5:108911758 G/T cg17395555 chr5:108820864 NA 0.51 7.48 0.42 1.11e-12 Colorectal cancer (SNP x SNP interaction); CESC cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg04455712 chr21:45112962 RRP1B 0.49 7.59 0.42 5.47e-13 Mean corpuscular volume; CESC cis rs10911363 0.592 rs10797886 chr1:183479090 T/C cg09173681 chr1:183549694 NCF2 0.52 7.84 0.43 1.12e-13 Systemic lupus erythematosus; CESC cis rs7927592 0.913 rs6591340 chr11:68297636 A/G cg20283391 chr11:68216788 NA -0.63 -7.58 -0.42 5.67e-13 Total body bone mineral density; CESC cis rs10779751 0.770 rs12075896 chr1:11200350 C/A cg08854313 chr1:11322531 MTOR -0.74 -8.99 -0.48 4.74e-17 Body mass index; CESC cis rs7107174 1.000 rs55761949 chr11:77993860 A/G cg02023728 chr11:77925099 USP35 0.48 6.64 0.38 1.74e-10 Testicular germ cell tumor; CESC cis rs7098414 0.511 rs7899513 chr10:82150559 G/A cg00277334 chr10:82204260 NA -0.5 -7.5 -0.42 9.84e-13 Post bronchodilator FEV1; CESC cis rs7659604 1.000 rs10016433 chr4:122664771 A/G cg19671926 chr4:122722719 EXOSC9 -0.44 -5.3 -0.31 2.49e-7 Type 2 diabetes; CESC cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg21138405 chr5:131827807 IRF1 0.54 9.24 0.49 8.12e-18 Asthma (sex interaction); CESC cis rs7772486 0.790 rs7753092 chr6:146248863 C/T cg23711669 chr6:146136114 FBXO30 -0.93 -13.61 -0.64 2.34e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.706 rs439537 chr17:37734482 T/C cg00129232 chr17:37814104 STARD3 -0.6 -6.11 -0.35 3.53e-9 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12799349 chr18:9475500 RALBP1 0.5 6.3 0.36 1.21e-9 Gut microbiome composition (summer); CESC cis rs2635047 1.000 rs2684841 chr18:44724262 C/T cg24371990 chr18:44770781 NA 0.34 5.46 0.32 1.07e-7 Educational attainment; CESC cis rs11997175 0.520 rs6994803 chr8:33817796 A/G ch.8.33884649F chr8:33765107 NA 0.59 7.38 0.41 2.05e-12 Body mass index; CESC cis rs6489785 0.509 rs3213570 chr12:121222411 C/G cg02419362 chr12:121203948 SPPL3 0.35 5.72 0.33 2.88e-8 Longevity;Allergic disease (asthma, hay fever or eczema); CESC cis rs7089973 0.604 rs7919649 chr10:116609576 T/C cg03647239 chr10:116582469 FAM160B1 0.45 5.62 0.33 4.93e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs3820928 0.845 rs2177596 chr2:227890283 A/T cg05526886 chr2:227700861 RHBDD1 -0.43 -5.47 -0.32 1.04e-7 Pulmonary function; CESC cis rs7089973 0.872 rs7072356 chr10:116634651 T/C cg23260525 chr10:116636907 FAM160B1 0.37 6.25 0.36 1.67e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs225245 0.782 rs321601 chr17:33892087 A/C cg05299278 chr17:33885742 SLFN14 -0.38 -5.53 -0.32 7.64e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs1152591 0.562 rs872227 chr14:64656165 T/C cg21174375 chr14:64681225 SYNE2 0.56 8.15 0.45 1.49e-14 Atrial fibrillation; CESC cis rs921968 0.565 rs6733892 chr2:219616002 C/A cg02176678 chr2:219576539 TTLL4 -0.47 -8.63 -0.47 5.97e-16 Mean corpuscular hemoglobin concentration; CESC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg02951883 chr7:2050386 MAD1L1 -0.45 -5.87 -0.34 1.31e-8 Bipolar disorder and schizophrenia; CESC cis rs7429990 0.965 rs4296617 chr3:48068308 T/C cg11946769 chr3:48343235 NME6 -0.5 -6.09 -0.35 4.02e-9 Educational attainment (years of education); CESC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.29e-7 Blood metabolite levels; CESC cis rs62229266 0.618 rs11088334 chr21:37466829 A/T cg08632701 chr21:37451849 NA -0.46 -6.26 -0.36 1.57e-9 Mitral valve prolapse; CESC cis rs8067545 0.750 rs7223305 chr17:19990986 A/G cg13482628 chr17:19912719 NA 0.37 5.09 0.3 6.81e-7 Schizophrenia; CESC cis rs7918232 0.941 rs4749230 chr10:27441218 C/T cg14240646 chr10:27532245 ACBD5 -0.65 -6.43 -0.37 5.89e-10 Breast cancer; CESC cis rs6687430 0.512 rs11121587 chr1:10618109 A/G cg20482658 chr1:10539492 PEX14 0.4 8.15 0.45 1.46e-14 Hand grip strength; CESC cis rs9486715 1.000 rs6899647 chr6:97065661 A/G cg18709589 chr6:96969512 KIAA0776 -0.46 -6.48 -0.37 4.56e-10 Headache; CESC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg19257562 chr1:2043853 PRKCZ -0.32 -5.23 -0.31 3.46e-7 Height; CESC cis rs7296418 0.961 rs4148863 chr12:123569375 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.33 -5.32 -0.31 2.23e-7 Platelet count; CESC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg03188948 chr7:1209495 NA 0.69 6.69 0.38 1.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6032067 0.852 rs17424613 chr20:43806441 C/T cg10761708 chr20:43804764 PI3 0.53 6.33 0.36 1.04e-9 Blood protein levels; CESC cis rs2985684 0.625 rs4900931 chr14:50022793 A/T cg04989706 chr14:50066350 PPIL5 -0.45 -5.18 -0.3 4.43e-7 Carotid intima media thickness; CESC cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg12350822 chr6:88032061 C6orf162;GJB7 0.5 8.34 0.46 4.21e-15 Monocyte percentage of white cells; CESC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg25072359 chr17:41440525 NA 0.47 6.91 0.39 3.6e-11 Menopause (age at onset); CESC cis rs916888 0.738 rs199515 chr17:44856641 C/G cg14517863 chr17:44321492 NA -0.41 -5.42 -0.32 1.33e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7666738 0.830 rs1111541 chr4:99033860 A/G cg05340658 chr4:99064831 C4orf37 -0.83 -12.78 -0.62 1.81e-29 Colonoscopy-negative controls vs population controls; CESC cis rs1348850 0.651 rs4893935 chr2:178240601 C/G cg22681709 chr2:178499509 PDE11A -0.35 -5.35 -0.31 1.92e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs1814175 0.645 rs1851853 chr11:49953434 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.08 19.85 0.77 2.44e-54 Height; CESC cis rs4455778 0.600 rs4244233 chr7:49130572 T/A cg26309511 chr7:48887640 NA 0.34 5.12 0.3 5.92e-7 Lung cancer in never smokers; CESC cis rs9457247 0.765 rs9457251 chr6:167426707 T/C cg07741184 chr6:167504864 NA 0.35 6.34 0.36 9.89e-10 Crohn's disease; CESC cis rs1153858 1.000 rs10519021 chr15:45631795 G/A cg14582100 chr15:45693742 SPATA5L1 0.41 5.89 0.34 1.18e-8 Homoarginine levels; CESC cis rs7707921 0.752 rs2897554 chr5:81276241 C/T cg15871215 chr5:81402204 ATG10 0.5 7.28 0.41 3.82e-12 Breast cancer; CESC cis rs1577917 1.000 rs12201735 chr6:86656939 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.86 -0.34 1.4e-8 Response to antipsychotic treatment; CESC cis rs208520 0.565 rs1385222 chr6:66753013 C/T cg07460842 chr6:66804631 NA 1.0 20.54 0.78 9.87e-57 Exhaled nitric oxide output; CESC cis rs2073300 1.000 rs115730610 chr20:23442621 G/A cg12062639 chr20:23401060 NAPB 0.9 6.28 0.36 1.4e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs926938 0.606 rs6537844 chr1:115289295 G/A cg12756093 chr1:115239321 AMPD1 -0.42 -5.23 -0.31 3.46e-7 Autism; CESC cis rs4979906 1.000 rs11002241 chr10:79445327 C/T cg00983440 chr10:79422392 NA -0.49 -5.15 -0.3 4.97e-7 Mortality in heart failure; CESC cis rs4689388 0.581 rs4476672 chr4:6281496 A/G cg14416269 chr4:6271139 WFS1 0.41 5.23 0.31 3.47e-7 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2109514 1.000 rs2270189 chr7:116140616 A/G cg12739419 chr7:116140593 CAV2 -0.37 -6.71 -0.38 1.17e-10 Prevalent atrial fibrillation; CESC cis rs9303401 0.659 rs17741087 chr17:56550300 C/T cg25039879 chr17:56429692 SUPT4H1 0.53 5.39 0.31 1.55e-7 Cognitive test performance; CESC cis rs9926296 0.656 rs2376883 chr16:89826926 A/G cg04287289 chr16:89883240 FANCA 0.57 7.62 0.42 4.55e-13 Vitiligo; CESC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.11 -0.3 6.3e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7809950 0.678 rs2237660 chr7:106862963 T/A cg23024343 chr7:107201750 COG5 -0.59 -7.11 -0.4 1.07e-11 Coronary artery disease; CESC cis rs1670533 1.000 rs62294756 chr4:1097676 G/A cg04106633 chr4:1044584 NA -0.4 -5.18 -0.3 4.5e-7 Recombination rate (females); CESC cis rs8180040 0.654 rs6766230 chr3:47196209 C/A cg27129171 chr3:47204927 SETD2 0.67 9.81 0.52 1.36e-19 Colorectal cancer; CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg18404041 chr3:52824283 ITIH1 -0.36 -6.45 -0.37 5.17e-10 Cognitive function; CESC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg26119090 chr2:26468346 HADHA;HADHB 0.84 9.21 0.49 1.06e-17 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.54 5.6 0.33 5.3e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21243608 chr8:74205946 RDH10;RPL7 0.55 6.61 0.38 2.1e-10 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg21926612 chr6:163149169 PACRG;PARK2 1.06 9.79 0.52 1.61e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9875589 0.957 rs1108341 chr3:13937328 T/A cg19554555 chr3:13937349 NA 0.52 6.57 0.37 2.63e-10 Ovarian reserve; CESC cis rs4253772 0.550 rs6008598 chr22:46704243 C/T cg10541313 chr22:46663664 TTC38 0.65 5.67 0.33 3.8e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4808199 1.000 rs4808199 chr19:19545099 C/T cg03709012 chr19:19516395 GATAD2A 1.11 12.74 0.62 2.57e-29 Nonalcoholic fatty liver disease; CESC cis rs11792861 0.591 rs4978763 chr9:111728067 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 8.87 0.48 1.07e-16 Menarche (age at onset); CESC cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg02297831 chr4:17616191 MED28 0.42 5.13 0.3 5.72e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9872999 1 rs9872999 chr3:133457514 C/T cg16262614 chr3:133464971 TF 0.41 8.07 0.44 2.47e-14 Iron status biomarkers; CESC cis rs72634258 0.945 rs12736494 chr1:8136016 G/A cg00042356 chr1:8021962 PARK7 0.82 7.73 0.43 2.19e-13 Inflammatory bowel disease; CESC cis rs9611565 0.512 rs132784 chr22:42052363 G/A cg06481639 chr22:41940642 POLR3H 0.6 6.16 0.35 2.74e-9 Vitiligo; CESC cis rs2072732 0.861 rs10909865 chr1:2956163 A/G cg15211996 chr1:2936768 ACTRT2 0.34 6.04 0.35 5.27e-9 Plateletcrit; CESC cis rs892961 0.932 rs2170863 chr17:75415037 C/T cg05865280 chr17:75406074 SEPT9 0.63 12.78 0.62 1.79e-29 Airflow obstruction; CESC cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg20307385 chr11:47447363 PSMC3 0.69 8.95 0.48 6.16e-17 Subjective well-being; CESC cis rs4268898 0.662 rs9917315 chr2:24431501 C/A cg20701182 chr2:24300061 SF3B14 0.68 7.16 0.4 7.75e-12 Asthma; CESC cis rs10186029 0.657 rs11689895 chr2:213938553 G/T cg08319019 chr2:214017104 IKZF2 0.4 5.07 0.3 7.39e-7 Systemic sclerosis; CESC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg10295955 chr4:187884368 NA -1.07 -19.89 -0.77 1.66e-54 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.7 0.43 2.77e-13 Prudent dietary pattern; CESC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.96 0.39 2.64e-11 Bipolar disorder; CESC cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs16854884 0.586 rs7650172 chr3:143729408 G/C cg06585982 chr3:143692056 C3orf58 0.52 6.99 0.39 2.18e-11 Economic and political preferences (feminism/equality); CESC cis rs11098499 0.954 rs3733523 chr4:120423719 C/T cg24375607 chr4:120327624 NA 0.46 5.66 0.33 3.87e-8 Corneal astigmatism; CESC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg17747265 chr1:1875780 NA -0.6 -9.77 -0.51 1.87e-19 Body mass index; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09799633 chr5:172199460 DUSP1 -0.5 -6.66 -0.38 1.53e-10 Asthma; CESC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.5 0.32 8.89e-8 Personality dimensions; CESC trans rs7824557 0.527 rs2736305 chr8:11237773 T/C cg06636001 chr8:8085503 FLJ10661 -0.48 -6.13 -0.35 3.25e-9 Retinal vascular caliber; CESC cis rs13102973 0.965 rs4280794 chr4:135857174 T/C cg14419869 chr4:135874104 NA 0.33 5.13 0.3 5.73e-7 Subjective well-being; CESC cis rs7000551 0.725 rs4871998 chr8:22308150 A/T cg12081754 chr8:22256438 SLC39A14 0.44 6.01 0.35 6.21e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs4319547 0.695 rs10773167 chr12:122934001 C/T cg05707623 chr12:122985044 ZCCHC8 -0.55 -6.27 -0.36 1.5e-9 Body mass index; CESC cis rs55883249 0.957 rs62119393 chr2:9718247 C/T cg23886495 chr2:9695866 ADAM17 0.57 5.37 0.31 1.74e-7 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs2294693 0.786 rs12055704 chr6:40988504 C/T cg14769373 chr6:40998127 UNC5CL -0.46 -5.7 -0.33 3.24e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg08736216 chr1:53307985 ZYG11A -0.4 -6.38 -0.36 8e-10 Monocyte count; CESC cis rs3091242 0.900 rs1883427 chr1:25744468 C/T cg27572855 chr1:25598939 RHD 0.46 7.61 0.42 4.81e-13 Erythrocyte sedimentation rate; CESC cis rs9611565 0.659 rs11090049 chr22:41915329 C/T cg03806693 chr22:41940476 POLR3H -1.21 -15.26 -0.68 3.73e-38 Vitiligo; CESC cis rs1387259 0.899 rs7307566 chr12:48604682 A/G cg04545296 chr12:48745243 ZNF641 0.4 6.74 0.38 9.66e-11 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs7917772 0.636 rs2863718 chr10:104519631 G/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -5.12 -0.3 5.79e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs8028182 0.636 rs8034317 chr15:75764343 G/A cg20655648 chr15:75932815 IMP3 0.48 6.02 0.35 5.83e-9 Sudden cardiac arrest; CESC cis rs1775715 0.737 rs2808028 chr10:32101189 G/A cg18675610 chr10:32216311 ARHGAP12 0.34 5.27 0.31 2.85e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs8070128 0.568 rs3935505 chr17:17882020 T/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.52 6.77 0.38 8.32e-11 Total body bone mineral density; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg07776409 chr17:27182127 ERAL1 -0.47 -6.07 -0.35 4.37e-9 Height; CESC trans rs61148964 0.826 rs11913459 chr22:37228603 G/A cg14267671 chr19:45572412 SFRS16 0.77 7.11 0.4 1.11e-11 Scarlet fever; CESC cis rs2249694 0.919 rs10857768 chr10:135402703 A/G cg20169779 chr10:135381914 SYCE1 -0.41 -5.79 -0.34 1.94e-8 Obesity-related traits; CESC cis rs1707322 1.000 rs785465 chr1:46522577 G/T cg03146154 chr1:46216737 IPP 0.7 9.41 0.5 2.42e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6831352 0.918 rs2851251 chr4:100044111 A/G cg12011299 chr4:100065546 ADH4 0.59 6.66 0.38 1.56e-10 Alcohol dependence; CESC cis rs9858542 0.953 rs9859556 chr3:49455986 G/T cg07274523 chr3:49395745 GPX1 0.65 7.92 0.44 6.53e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs854765 0.583 rs8065416 chr17:17851162 C/T cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg23758822 chr17:41437982 NA 1.03 15.83 0.7 3.63e-40 Menopause (age at onset); CESC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 11.05 0.56 1.37e-23 Platelet count; CESC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.59 6.65 0.38 1.64e-10 IgG glycosylation; CESC cis rs9309473 1.000 rs6546837 chr2:73677898 G/C cg20560298 chr2:73613845 ALMS1 -0.46 -6.17 -0.35 2.53e-9 Metabolite levels; CESC cis rs7845219 0.544 rs7017487 chr8:95922752 A/G cg13393036 chr8:95962371 TP53INP1 0.43 8.37 0.46 3.4e-15 Type 2 diabetes; CESC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.1 0.3 6.59e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7727544 0.709 rs441969 chr5:131702120 G/A cg24060327 chr5:131705240 SLC22A5 -0.63 -7.98 -0.44 4.32e-14 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25388971 chr5:1085895 SLC12A7 -0.51 -6.11 -0.35 3.55e-9 Gut microbiome composition (summer); CESC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.45 5.36 0.31 1.79e-7 Renal function-related traits (BUN); CESC cis rs10751667 0.857 rs6597961 chr11:976677 T/C cg06064525 chr11:970664 AP2A2 -0.37 -6.51 -0.37 3.85e-10 Alzheimer's disease (late onset); CESC cis rs694739 0.726 rs516124 chr11:64128423 G/T cg02228329 chr11:64053129 BAD;GPR137 0.62 7.81 0.43 1.3e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg02297831 chr4:17616191 MED28 0.5 6.07 0.35 4.52e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.78 9.62 0.51 5.44e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs11190604 1.000 rs11190613 chr10:102313997 C/T cg07080220 chr10:102295463 HIF1AN -0.62 -5.92 -0.34 9.93e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs9908102 0.740 rs73981609 chr17:12903938 T/C cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03576123 chr11:487126 PTDSS2 -1.04 -10.29 -0.53 4.01e-21 Body mass index; CESC cis rs938554 0.513 rs3775948 chr4:9995182 G/C cg11266682 chr4:10021025 SLC2A9 0.5 7.24 0.41 4.79e-12 Blood metabolite levels; CESC cis rs9486719 0.741 rs2499799 chr6:96851676 T/C cg06623918 chr6:96969491 KIAA0776 0.74 7.03 0.4 1.77e-11 Migraine;Coronary artery disease; CESC trans rs2965280 0.793 rs8101748 chr19:34822331 C/G cg05799317 chr6:165723796 C6orf118 0.81 6.0 0.35 6.45e-9 Colorectal cancer; CESC cis rs2635047 0.901 rs2684837 chr18:44749884 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.58 0.32 6.06e-8 Educational attainment; CESC trans rs801193 1.000 rs2707854 chr7:66212597 G/A cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC cis rs8060686 0.858 rs7198357 chr16:67884619 A/G cg26727032 chr16:67993705 SLC12A4 0.64 9.34 0.5 4.23e-18 HDL cholesterol;Metabolic syndrome; CESC cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg23649088 chr2:200775458 C2orf69 -0.73 -9.47 -0.5 1.61e-18 Osteoporosis; CESC cis rs5753037 0.653 rs131286 chr22:30158351 C/T cg01021169 chr22:30184971 ASCC2 -0.45 -6.27 -0.36 1.48e-9 Type 1 diabetes; CESC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg23161317 chr6:28129485 ZNF389 0.5 6.19 0.36 2.3e-9 Depression; CESC cis rs9394159 0.583 rs4713650 chr6:33616828 C/T cg14003231 chr6:33640908 ITPR3 -0.44 -8.02 -0.44 3.37e-14 Graves' disease; CESC cis rs61332075 0.501 rs55706928 chr2:239445806 T/C cg18131467 chr2:239335373 ASB1 -0.7 -5.59 -0.32 5.74e-8 Lung function (FEV1/FVC); CESC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Depression; CESC trans rs9325144 0.723 rs11169519 chr12:39177441 G/A cg23762105 chr12:34175262 ALG10 0.45 6.06 0.35 4.7e-9 Morning vs. evening chronotype; CESC cis rs3857067 1.000 rs28876091 chr4:95000394 A/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.0 -0.44 3.93e-14 QT interval; CESC cis rs10911232 0.507 rs3934578 chr1:183027216 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 13.49 0.64 6.27e-32 Hypertriglyceridemia; CESC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg04414720 chr1:150670196 GOLPH3L 0.47 6.42 0.37 6.09e-10 Melanoma; CESC cis rs9457247 1.000 rs415842 chr6:167406681 G/A cg23791538 chr6:167370224 RNASET2 -0.59 -8.54 -0.46 1.09e-15 Crohn's disease; CESC cis rs7927592 0.763 rs596494 chr11:68251054 T/G cg16797656 chr11:68205561 LRP5 0.5 7.71 0.43 2.59e-13 Total body bone mineral density; CESC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Tonsillectomy; CESC cis rs1348850 0.874 rs6742951 chr2:178340766 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.89 12.4 0.61 3.73e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6963495 0.818 rs73192145 chr7:105203628 A/C cg19920283 chr7:105172520 RINT1 0.68 6.26 0.36 1.56e-9 Bipolar disorder (body mass index interaction); CESC cis rs12477438 0.798 rs6542848 chr2:99573732 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.73 -10.49 -0.54 9.44e-22 Chronic sinus infection; CESC cis rs7590720 1.000 rs4674058 chr2:216909368 A/G cg12620499 chr2:216877984 MREG 0.91 12.11 0.6 3.59e-27 Alcohol dependence; CESC cis rs2832191 0.765 rs2832162 chr21:30461808 G/A cg08807101 chr21:30365312 RNF160 0.79 11.13 0.56 7.53e-24 Dental caries; CESC cis rs12142240 0.698 rs17361763 chr1:46810670 T/C cg10495392 chr1:46806563 NSUN4 0.59 6.35 0.36 9.17e-10 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21902160 chr7:29689075 LOC646762 -0.48 -6.08 -0.35 4.15e-9 Gut microbiome composition (summer); CESC cis rs8062405 1.000 rs62037365 chr16:28868962 C/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.84 -0.34 1.49e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6835098 0.962 rs3733477 chr4:174090004 G/A cg08422745 chr4:174089978 GALNT7 -0.81 -11.84 -0.59 3.03e-26 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs6912958 0.559 rs173333 chr6:88047754 T/G cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.99 0.56 2.06e-23 Monocyte percentage of white cells; CESC cis rs4819052 0.788 rs35323494 chr21:46703739 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 12.44 0.61 2.65e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs1814175 0.817 rs11493756 chr11:50017885 T/C cg15704280 chr7:45808275 SEPT13 -1.05 -20.74 -0.79 2.04e-57 Height; CESC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.64 0.33 4.45e-8 Menopause (age at onset); CESC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.76 -0.55 1.2e-22 Alzheimer's disease; CESC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg02725872 chr8:58115012 NA -0.34 -5.09 -0.3 6.69e-7 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg07507251 chr3:52567010 NT5DC2 0.4 6.98 0.39 2.43e-11 Bipolar disorder; CESC cis rs3820068 0.577 rs9728986 chr1:16040603 G/A cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.35 4.28e-9 Systolic blood pressure; CESC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg08684580 chr7:98029266 BAIAP2L1 0.34 5.49 0.32 9.58e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC cis rs2742234 0.955 rs1800861 chr10:43613843 G/T cg07801480 chr10:43725741 RASGEF1A 0.38 5.27 0.31 2.82e-7 Hirschsprung disease; CESC cis rs1707322 0.827 rs12125508 chr1:46246010 A/G cg05343316 chr1:45956843 TESK2 0.47 5.73 0.33 2.75e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg20891558 chr2:74357851 NA -0.66 -9.0 -0.48 4.51e-17 Gestational age at birth (maternal effect); CESC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg11859384 chr17:80120422 CCDC57 0.38 5.15 0.3 5.1e-7 Life satisfaction; CESC cis rs12586317 0.514 rs74590021 chr14:35490113 T/G cg16230307 chr14:35515116 FAM177A1 0.99 10.62 0.55 3.59e-22 Psoriasis; CESC cis rs9303401 0.659 rs34878689 chr17:56694330 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.02 11.73 0.58 7.25e-26 Cognitive test performance; CESC cis rs8077577 0.747 rs16961153 chr17:18227101 A/G cg16794390 chr17:18148240 FLII -0.4 -6.2 -0.36 2.1e-9 Obesity-related traits; CESC cis rs12682352 0.602 rs6993494 chr8:8667444 C/T cg17143192 chr8:8559678 CLDN23 0.45 5.31 0.31 2.34e-7 Neuroticism; CESC cis rs1775715 0.870 rs1755084 chr10:32253709 C/T cg18675610 chr10:32216311 ARHGAP12 0.35 5.38 0.31 1.64e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg13877915 chr19:58951672 ZNF132 0.42 6.23 0.36 1.84e-9 Uric acid clearance; CESC cis rs1843834 0.539 rs6749402 chr2:225443901 T/G cg22455342 chr2:225449267 CUL3 0.7 9.61 0.51 6.05e-19 IgE levels in asthmatics (D.p. specific); CESC cis rs10392 0.543 rs6015981 chr20:37533958 A/G cg27552599 chr20:37590471 DHX35 0.39 5.64 0.33 4.42e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs3126085 1.000 rs72696989 chr1:152248674 A/C cg03465714 chr1:152285911 FLG 0.49 5.43 0.32 1.24e-7 Atopic dermatitis; CESC cis rs16858210 0.837 rs11716104 chr3:183581999 G/C cg25686905 chr3:183603175 PARL -0.33 -6.08 -0.35 4.24e-9 Menopause (age at onset); CESC cis rs656900 0.669 rs665629 chr15:80119231 C/A cg02196730 chr15:80188777 MTHFS -0.4 -5.29 -0.31 2.52e-7 Cerebrospinal P-tau181p levels; CESC cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg00255919 chr5:131827918 IRF1 0.51 8.68 0.47 4.19e-16 Asthma (sex interaction); CESC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg03609598 chr5:56110824 MAP3K1 -0.49 -5.08 -0.3 7.22e-7 Initial pursuit acceleration; CESC cis rs12765878 1.000 rs11191847 chr10:105650626 G/C cg24587175 chr10:105670608 OBFC1 0.33 5.43 0.32 1.28e-7 Coronary artery disease; CESC cis rs1559088 0.803 rs10411529 chr19:33616256 A/C cg17764715 chr19:33622953 WDR88 0.44 5.59 0.33 5.51e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs5758659 0.652 rs5758553 chr22:42431429 G/A cg04733989 chr22:42467013 NAGA 0.47 6.62 0.38 2.04e-10 Cognitive function; CESC cis rs7481584 0.624 rs80871 chr11:3049843 A/C cg25174290 chr11:3078921 CARS -0.45 -6.27 -0.36 1.48e-9 Calcium levels; CESC cis rs473651 0.935 rs540636 chr2:239358341 T/C cg21699342 chr2:239360505 ASB1 0.58 10.26 0.53 5.15e-21 Multiple system atrophy; CESC cis rs992157 0.700 rs10165153 chr2:219159629 T/C cg00012203 chr2:219082015 ARPC2 0.75 9.7 0.51 3.1e-19 Colorectal cancer; CESC cis rs7662987 0.818 rs4699701 chr4:99998447 G/A cg13256891 chr4:100009986 ADH5 -0.82 -6.07 -0.35 4.52e-9 Smoking initiation; CESC cis rs2718058 0.519 rs2598047 chr7:37888488 G/T cg24998770 chr7:37888106 TXNDC3 0.34 5.17 0.3 4.53e-7 Alzheimer's disease (late onset); CESC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg08888203 chr3:10149979 C3orf24 0.48 6.09 0.35 3.99e-9 Alzheimer's disease; CESC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg06456125 chr7:65229604 NA -0.39 -5.09 -0.3 6.82e-7 Aortic root size; CESC cis rs11098499 0.909 rs28632018 chr4:120386730 T/C cg24375607 chr4:120327624 NA 0.44 5.48 0.32 9.91e-8 Corneal astigmatism; CESC cis rs6121246 0.609 rs4453755 chr20:30331047 G/A cg13852791 chr20:30311386 BCL2L1 0.81 10.36 0.54 2.4e-21 Mean corpuscular hemoglobin; CESC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg11235426 chr6:292522 DUSP22 -0.72 -9.67 -0.51 3.98e-19 Menopause (age at onset); CESC cis rs35110281 0.687 rs4819284 chr21:45084548 C/T cg21573476 chr21:45109991 RRP1B -0.43 -6.14 -0.35 3.04e-9 Mean corpuscular volume; CESC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.27e-16 Colonoscopy-negative controls vs population controls; CESC trans rs7944735 0.567 rs7111404 chr11:48011283 C/G cg15704280 chr7:45808275 SEPT13 0.68 6.1 0.35 3.77e-9 Intraocular pressure; CESC cis rs1577917 0.771 rs9450290 chr6:86233397 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.57 7.9 0.44 7.24e-14 Response to antipsychotic treatment; CESC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg26335602 chr6:28129616 ZNF389 0.53 6.86 0.39 4.81e-11 Depression; CESC cis rs2243480 1.000 rs73142122 chr7:65311298 C/A cg12463550 chr7:65579703 CRCP 0.69 5.53 0.32 7.85e-8 Diabetic kidney disease; CESC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg11764359 chr7:65958608 NA -0.69 -8.94 -0.48 6.63e-17 Aortic root size; CESC cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg23158103 chr7:148848205 ZNF398 -0.41 -6.47 -0.37 4.71e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs8141529 0.871 rs5762877 chr22:29277555 G/A cg02153584 chr22:29168773 CCDC117 0.55 7.25 0.41 4.5e-12 Lymphocyte counts; CESC cis rs7605827 0.930 rs2049718 chr2:15518589 A/G cg19274914 chr2:15703543 NA -0.34 -6.09 -0.35 4.04e-9 Educational attainment (years of education); CESC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg19163074 chr7:65112434 INTS4L2 0.41 5.18 0.3 4.32e-7 Aortic root size; CESC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg06456125 chr7:65229604 NA 0.43 5.49 0.32 9.18e-8 Calcium levels; CESC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg26818010 chr10:134567672 INPP5A -0.83 -10.11 -0.53 1.59e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg18904891 chr8:8559673 CLDN23 0.67 7.69 0.43 2.98e-13 Obesity-related traits; CESC cis rs12893668 0.628 rs57072546 chr14:104063723 T/C cg24130564 chr14:104152367 KLC1 -0.49 -6.16 -0.35 2.64e-9 Reticulocyte count; CESC cis rs826838 0.616 rs10880751 chr12:38627485 C/T cg26384229 chr12:38710491 ALG10B 0.47 6.36 0.36 8.58e-10 Heart rate; CESC cis rs2777491 0.789 rs316617 chr15:41795900 C/T cg18705301 chr15:41695430 NDUFAF1 0.58 8.2 0.45 1.03e-14 Ulcerative colitis; CESC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg22800045 chr5:56110881 MAP3K1 0.81 9.66 0.51 4.1e-19 Initial pursuit acceleration; CESC cis rs9858542 1.000 rs13316695 chr3:49684917 C/G cg07274523 chr3:49395745 GPX1 0.67 8.54 0.46 1.03e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1707322 0.691 rs12031182 chr1:46220999 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9611565 0.525 rs9611548 chr22:41704143 G/T cg06481639 chr22:41940642 POLR3H -0.53 -5.64 -0.33 4.31e-8 Vitiligo; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21871735 chr16:2015157 SNHG9;RPS2;SNORA78 0.52 6.76 0.38 8.9e-11 Gut microbiota (bacterial taxa); CESC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg07701084 chr6:150067640 NUP43 0.48 6.85 0.39 5.03e-11 Lung cancer; CESC cis rs3785574 0.621 rs1051684 chr17:62006497 A/G cg11494091 chr17:61959527 GH2 -0.39 -5.62 -0.33 4.94e-8 Height; CESC cis rs2952156 1.000 rs2643195 chr17:37853118 A/G cg00129232 chr17:37814104 STARD3 -0.71 -9.57 -0.51 7.77e-19 Asthma; CESC cis rs1348850 0.914 rs1348849 chr2:178358072 C/T cg23306229 chr2:178417860 TTC30B 0.66 8.32 0.46 4.61e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs17376456 0.877 rs10065056 chr5:93380123 G/T cg21475434 chr5:93447410 FAM172A 0.77 6.95 0.39 2.86e-11 Diabetic retinopathy; CESC cis rs3749237 0.595 rs3870338 chr3:49557051 A/G cg07636037 chr3:49044803 WDR6 0.61 9.06 0.49 2.96e-17 Resting heart rate; CESC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg24250549 chr1:154909240 PMVK 0.62 8.49 0.46 1.46e-15 Prostate cancer; CESC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg21856205 chr7:94953877 PON1 -0.48 -7.06 -0.4 1.5e-11 Paraoxonase activity; CESC cis rs2635047 0.967 rs7242978 chr18:44633424 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.56 -7.81 -0.43 1.3e-13 Educational attainment; CESC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.86 -0.34 1.38e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7089973 0.604 rs7920216 chr10:116611794 G/A cg23260525 chr10:116636907 FAM160B1 0.38 6.84 0.39 5.48e-11 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9522267 0.535 rs11069900 chr13:112233285 G/A cg10483660 chr13:112241077 NA -0.33 -5.79 -0.33 2.04e-8 Hepatitis; CESC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg00129232 chr17:37814104 STARD3 -0.58 -8.15 -0.45 1.43e-14 Glomerular filtration rate (creatinine); CESC cis rs11785400 0.793 rs4457308 chr8:143733922 G/A cg10596483 chr8:143751796 JRK 0.43 5.53 0.32 7.5e-8 Schizophrenia; CESC cis rs34779708 0.966 rs17591163 chr10:35465279 G/C cg04310649 chr10:35416472 CREM -0.52 -6.33 -0.36 1.06e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs5769765 0.954 rs1569954 chr22:50244071 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.47 5.47 0.32 1.07e-7 Schizophrenia; CESC cis rs1461503 0.932 rs10790544 chr11:122838330 T/C cg27398637 chr11:122830231 C11orf63 -0.57 -8.68 -0.47 4.17e-16 Menarche (age at onset); CESC cis rs12617721 0.645 rs114544871 chr2:99045485 T/G cg10123293 chr2:99228465 UNC50 0.39 5.1 0.3 6.52e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7267979 0.899 rs2104734 chr20:25526668 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.76 13.66 0.64 1.58e-32 Liver enzyme levels (alkaline phosphatase); CESC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg03526776 chr6:41159608 TREML2 0.39 6.54 0.37 3.21e-10 Alzheimer's disease (late onset); CESC cis rs3026101 0.624 rs12601818 chr17:5320438 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.49 0.32 9.32e-8 Body mass index; CESC trans rs9467711 0.606 rs9393715 chr6:26375645 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -6.67 -0.38 1.48e-10 Autism spectrum disorder or schizophrenia; CESC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg17372223 chr3:52568218 NT5DC2 0.39 5.92 0.34 9.69e-9 Electroencephalogram traits; CESC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg08736216 chr1:53307985 ZYG11A 0.4 6.55 0.37 3.06e-10 Monocyte count; CESC cis rs1215050 0.791 rs1669745 chr4:98842047 G/A cg05340658 chr4:99064831 C4orf37 -0.5 -6.49 -0.37 4.24e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9486715 0.867 rs4240553 chr6:96965324 T/C cg18709589 chr6:96969512 KIAA0776 0.47 6.57 0.37 2.6200000000000003e-10 Headache; CESC cis rs684232 0.602 rs394747 chr17:562495 C/G cg15660573 chr17:549704 VPS53 0.81 11.99 0.59 9.32e-27 Prostate cancer; CESC cis rs6754311 0.731 rs745500 chr2:136583192 G/A cg15123519 chr2:136567270 LCT 0.33 5.59 0.33 5.51e-8 Mosquito bite size; CESC cis rs3820928 0.874 rs10189579 chr2:227864876 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -5.45 -0.32 1.12e-7 Pulmonary function; CESC trans rs55704346 0.534 rs2292406 chr4:25393475 T/A cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs3820928 0.874 rs1917123 chr2:227889783 T/G cg11843606 chr2:227700838 RHBDD1 -0.44 -5.72 -0.33 2.88e-8 Pulmonary function; CESC cis rs9815354 0.723 rs79741604 chr3:41947321 C/T cg03022575 chr3:42003672 ULK4 0.71 6.45 0.37 5.42e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg14784868 chr12:69753453 YEATS4 0.74 10.82 0.55 7.97e-23 Blood protein levels; CESC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg23172400 chr8:95962367 TP53INP1 -0.45 -9.24 -0.49 8.35e-18 Type 2 diabetes; CESC cis rs6963495 0.818 rs73190161 chr7:105156871 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs9925964 0.967 rs1549293 chr16:31141993 C/T cg02466173 chr16:30829666 NA 0.34 5.08 0.3 6.96e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3008870 1.000 rs2009319 chr1:67481070 G/T cg02640540 chr1:67518911 SLC35D1 0.51 5.43 0.32 1.25e-7 Lymphocyte percentage of white cells; CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg04025307 chr7:1156635 C7orf50 0.5 8.19 0.45 1.09e-14 Longevity;Endometriosis; CESC cis rs3857536 0.813 rs7768944 chr6:66951088 C/T cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs703842 0.616 rs10783851 chr12:58231155 A/G cg04478727 chr12:58166393 METTL1;FAM119B -0.56 -6.46 -0.37 5e-10 Multiple sclerosis; CESC cis rs936229 0.749 rs6495127 chr15:75194490 C/T cg14664628 chr15:75095509 CSK -0.69 -8.38 -0.46 3.12e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.67 6.46 0.37 5.02e-10 LDL cholesterol;Cholesterol, total; CESC cis rs6502050 0.805 rs6502061 chr17:80086158 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.13 0.3 5.62e-7 Life satisfaction; CESC cis rs6032067 0.929 rs2267864 chr20:43805279 C/G cg10761708 chr20:43804764 PI3 0.41 5.06 0.3 7.86e-7 Blood protein levels; CESC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg23758822 chr17:41437982 NA 1.03 14.68 0.67 3.99e-36 Menopause (age at onset); CESC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg08704250 chr15:31115839 NA -0.63 -8.12 -0.45 1.8e-14 Huntington's disease progression; CESC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg11764359 chr7:65958608 NA -0.73 -9.65 -0.51 4.47e-19 Aortic root size; CESC cis rs12200782 0.505 rs7765920 chr6:26514771 C/T cg11502198 chr6:26597334 ABT1 0.6 6.88 0.39 4.26e-11 Small cell lung carcinoma; CESC cis rs589448 0.902 rs315131 chr12:69761839 T/G cg22834771 chr12:69754056 YEATS4 -0.57 -7.68 -0.43 3.15e-13 Cerebrospinal fluid biomarker levels; CESC cis rs6032067 0.777 rs34233258 chr20:43788265 G/A cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.32e-7 Colonoscopy-negative controls vs population controls; CESC cis rs738322 0.967 rs133018 chr22:38572761 G/A cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC cis rs3087591 0.960 rs2071009 chr17:29558082 T/C cg24425628 chr17:29625626 OMG;NF1 -0.45 -5.59 -0.32 5.73e-8 Hip circumference; CESC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg03388025 chr16:89894329 SPIRE2 0.41 7.89 0.44 7.86e-14 Vitiligo; CESC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.94 0.52 5.31e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6089584 0.586 rs1079755 chr20:60615262 G/A cg06108461 chr20:60628389 TAF4 -0.59 -7.89 -0.44 7.98e-14 Body mass index; CESC cis rs9457247 0.602 rs9457262 chr6:167473685 A/G cg07741184 chr6:167504864 NA 0.38 6.7 0.38 1.22e-10 Crohn's disease; CESC cis rs72781680 0.848 rs72780199 chr2:24016269 A/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg22307029 chr19:49891270 CCDC155 0.74 8.79 0.48 1.95e-16 Multiple sclerosis; CESC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC trans rs765547 0.956 rs2410618 chr8:19853500 G/A cg12649343 chr22:47023005 GRAMD4 -0.3 -6.12 -0.35 3.27e-9 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs7586879 0.681 rs28836469 chr2:25117215 A/G cg01884057 chr2:25150051 NA 0.37 7.12 0.4 1.03e-11 Body mass index; CESC cis rs6866344 0.570 rs4266420 chr5:178137161 C/G cg10224037 chr5:178157518 ZNF354A 0.71 8.44 0.46 2.11e-15 Neutrophil percentage of white cells; CESC cis rs7617773 0.780 rs11706277 chr3:48360433 A/G cg11946769 chr3:48343235 NME6 0.91 11.67 0.58 1.12e-25 Coronary artery disease; CESC cis rs3771570 1.000 rs73020143 chr2:242261240 T/A cg21155796 chr2:242212141 HDLBP 0.59 5.03 0.3 9.15e-7 Prostate cancer; CESC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg21747405 chr11:67723411 NA -0.45 -6.91 -0.39 3.66e-11 Blood pressure (smoking interaction); CESC cis rs9611565 0.681 rs132918 chr22:41808350 C/T cg06481639 chr22:41940642 POLR3H 0.58 6.34 0.36 9.76e-10 Vitiligo; CESC cis rs2486288 0.656 rs1719236 chr15:45577783 G/T cg21132104 chr15:45694354 SPATA5L1 -0.53 -6.16 -0.35 2.67e-9 Glomerular filtration rate; CESC cis rs9467711 0.790 rs13195402 chr6:26463575 G/T cg21479132 chr6:26055353 NA 0.82 5.71 0.33 3.05e-8 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02709840 chr16:67062875 CBFB 0.61 6.68 0.38 1.37e-10 Gut microbiome composition (summer); CESC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg04317338 chr11:64019027 PLCB3 0.79 8.11 0.45 1.95e-14 Mean platelet volume; CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -5.64 -0.33 4.42e-8 Electroencephalogram traits; CESC cis rs854765 0.583 rs9890341 chr17:17823175 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.28 0.41 3.9e-12 Total body bone mineral density; CESC cis rs1050631 0.527 rs592261 chr18:33752244 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.58 7.8 0.43 1.41e-13 Esophageal squamous cell cancer (length of survival); CESC cis rs72781680 1.000 rs72781665 chr2:24223086 G/A cg20701182 chr2:24300061 SF3B14 0.66 5.79 0.34 1.95e-8 Lymphocyte counts; CESC cis rs763014 0.966 rs15564 chr16:677854 G/T cg07256732 chr16:621771 PIGQ -0.3 -5.32 -0.31 2.26e-7 Height; CESC cis rs4566357 1.000 rs10933167 chr2:227925969 T/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.45 -0.32 1.16e-7 Coronary artery disease; CESC cis rs2228479 0.867 rs62052168 chr16:89947203 G/A cg00800038 chr16:89945340 TCF25 -0.95 -8.0 -0.44 3.92e-14 Skin colour saturation; CESC cis rs7258465 1.000 rs4808801 chr19:18571141 A/G cg15073853 chr19:18549131 ISYNA1 -0.36 -5.06 -0.3 7.9e-7 Breast cancer; CESC cis rs6088580 0.634 rs6058041 chr20:33018008 A/G cg24642439 chr20:33292090 TP53INP2 0.51 6.76 0.38 8.73e-11 Glomerular filtration rate (creatinine); CESC cis rs3026101 0.671 rs12603639 chr17:5320808 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.59 0.32 5.61e-8 Body mass index; CESC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs3793683 0.597 rs2182620 chr10:134590715 C/T cg27286337 chr10:134555280 INPP5A 0.7 8.14 0.45 1.6e-14 Migraine; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg11190155 chr3:9975447 CRELD1 -0.49 -6.38 -0.36 7.97e-10 Height; CESC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.55 0.42 7.03e-13 Bipolar disorder; CESC cis rs830124 0.602 rs1678952 chr12:122385151 C/A cg22168489 chr12:122356033 WDR66 -0.37 -5.03 -0.3 9.21e-7 Urinary metabolites; CESC cis rs3936840 0.647 rs942024 chr14:102979463 C/T cg18135206 chr14:102964638 TECPR2 0.43 5.66 0.33 3.93e-8 Plateletcrit; CESC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg00784671 chr22:46762841 CELSR1 -0.48 -5.58 -0.32 5.83e-8 LDL cholesterol;Cholesterol, total; CESC cis rs12477438 0.520 rs11123763 chr2:99750673 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.81 0.7 4.17e-40 Chronic sinus infection; CESC cis rs8141529 0.778 rs763073 chr22:29215542 G/A cg02153584 chr22:29168773 CCDC117 0.63 9.03 0.49 3.69e-17 Lymphocyte counts; CESC cis rs7666738 0.830 rs59751489 chr4:98933802 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs798766 1.000 rs1665364 chr4:1727206 A/G cg05874882 chr4:1763078 NA 0.6 8.08 0.44 2.24e-14 Bladder cancer;Urinary bladder cancer; CESC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg21782813 chr7:2030301 MAD1L1 0.5 7.01 0.4 2.01e-11 Bipolar disorder and schizophrenia; CESC cis rs919433 0.963 rs4850786 chr2:198178608 A/G cg10820045 chr2:198174542 NA 0.37 5.04 0.3 8.74e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9291683 0.530 rs11723591 chr4:9985398 T/A cg11266682 chr4:10021025 SLC2A9 0.58 11.31 0.57 1.86e-24 Bone mineral density; CESC trans rs2727020 0.894 rs10839265 chr11:49369733 C/T cg03929089 chr4:120376271 NA -0.65 -7.61 -0.42 4.95e-13 Coronary artery disease; CESC trans rs948562 0.744 rs113707421 chr11:58217142 T/A cg24637035 chr12:120445227 CCDC64 -0.5 -6.06 -0.35 4.67e-9 Lymphoma; CESC trans rs7672847 0.546 rs10461329 chr4:170518527 G/C cg19308436 chr1:237949471 RYR2 0.57 6.33 0.36 1.04e-9 Subjective well-being; CESC cis rs1707322 1.000 rs1707317 chr1:46510642 C/T cg05343316 chr1:45956843 TESK2 -0.49 -5.89 -0.34 1.19e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7772486 0.875 rs7739418 chr6:146359188 G/A cg23711669 chr6:146136114 FBXO30 0.76 11.02 0.56 1.67e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs3820928 0.874 rs4234066 chr2:227882180 G/A cg11843606 chr2:227700838 RHBDD1 -0.46 -6.09 -0.35 3.87e-9 Pulmonary function; CESC cis rs977987 0.736 rs11865296 chr16:75473693 C/T cg03315344 chr16:75512273 CHST6 0.43 6.11 0.35 3.48e-9 Dupuytren's disease; CESC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg08859206 chr1:53392774 SCP2 0.54 7.15 0.4 8.22e-12 Monocyte count; CESC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg06505273 chr16:24850292 NA -0.46 -5.68 -0.33 3.53e-8 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg05340658 chr4:99064831 C4orf37 0.74 10.67 0.55 2.43e-22 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs10079760 chr5:230778 A/G cg22496380 chr5:211416 CCDC127 -0.71 -8.24 -0.45 7.97e-15 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05643703 chr1:17332012 ATP13A2 -0.59 -6.58 -0.37 2.47e-10 Gut microbiome composition (summer); CESC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 11.28 0.57 2.4e-24 Platelet count; CESC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.36 -6.18 -0.35 2.41e-9 Bipolar disorder; CESC cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg22875332 chr1:76189707 ACADM -0.58 -6.06 -0.35 4.53e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3820928 0.967 rs4675113 chr2:227766339 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.71 -0.33 3.04e-8 Pulmonary function; CESC cis rs1538970 0.884 rs781232 chr1:45890399 C/T cg24296786 chr1:45957014 TESK2 0.44 5.35 0.31 1.87e-7 Platelet count; CESC trans rs13360092 0.764 rs77197369 chr5:50541122 G/A cg03200537 chr16:87022121 NA 0.69 6.01 0.35 6.12e-9 Verbal declarative memory; CESC cis rs7945705 0.902 rs7930026 chr11:9013639 T/C cg09997546 chr11:8931473 C11orf17;ST5 0.35 5.83 0.34 1.61e-8 Hemoglobin concentration; CESC trans rs6759922 1.000 rs4557006 chr2:22443840 C/T cg21162304 chr4:80247171 NAA11 0.39 6.23 0.36 1.83e-9 Subjective well-being (multi-trait analysis); CESC cis rs2075371 0.501 rs1646654 chr7:134027547 G/C cg20476274 chr7:133979776 SLC35B4 0.42 5.25 0.31 3.11e-7 Mean platelet volume; CESC cis rs372883 0.648 rs1003772 chr21:30736145 A/T cg24692254 chr21:30365293 RNF160 0.53 6.56 0.37 2.86e-10 Pancreatic cancer; CESC trans rs561341 0.700 rs8079471 chr17:30218317 A/G cg20587970 chr11:113659929 NA -0.63 -8.24 -0.45 8.02e-15 Hip circumference adjusted for BMI; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03255221 chr20:57617810 SLMO2 -0.48 -6.25 -0.36 1.62e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1003719 0.743 rs2835615 chr21:38497303 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.64 -8.74 -0.47 2.66e-16 Eye color traits; CESC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg18190219 chr22:46762943 CELSR1 -0.56 -6.44 -0.37 5.69e-10 LDL cholesterol;Cholesterol, total; CESC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.25 0.53 5.38e-21 Mean platelet volume; CESC cis rs55728055 0.661 rs7286496 chr22:31983760 G/A cg01338084 chr22:32026380 PISD 1.26 8.55 0.47 9.7e-16 Age-related hearing impairment; CESC cis rs6547741 1.000 rs10165098 chr2:27796526 C/T cg27432699 chr2:27873401 GPN1 0.49 6.92 0.39 3.35e-11 Oral cavity cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03425468 chr1:155164676 MIR92B 0.43 6.05 0.35 4.98e-9 Gut microbiota (bacterial taxa); CESC cis rs10751667 0.580 rs10751664 chr11:927077 T/G cg20946044 chr11:1010712 AP2A2 -0.39 -5.26 -0.31 2.96e-7 Alzheimer's disease (late onset); CESC cis rs2235544 0.664 rs41366847 chr1:54476967 C/G cg25741118 chr1:54482237 LDLRAD1 -0.24 -6.21 -0.36 2.01e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs3733585 0.699 rs4621431 chr4:9947590 C/T cg00071950 chr4:10020882 SLC2A9 -0.72 -10.91 -0.56 3.85e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg16680214 chr1:154839983 KCNN3 -0.45 -6.79 -0.39 7.19e-11 Prostate cancer; CESC cis rs3820068 0.705 rs4646022 chr1:15839112 G/A cg17385448 chr1:15911702 AGMAT 0.37 5.87 0.34 1.27e-8 Systolic blood pressure; CESC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg10691866 chr7:65817282 TPST1 -0.34 -5.47 -0.32 1.06e-7 Aortic root size; CESC cis rs17826219 0.706 rs57698184 chr17:29064918 T/C cg14008862 chr17:28927542 LRRC37B2 0.64 5.11 0.3 6.29e-7 Body mass index; CESC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg11764359 chr7:65958608 NA 0.81 11.89 0.59 2.11e-26 Aortic root size; CESC cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.71 0.47 3.23e-16 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.7 0.43 2.77e-13 Prudent dietary pattern; CESC cis rs17209837 0.607 rs11561963 chr7:87116550 T/A cg00919237 chr7:87102261 ABCB4 -0.46 -5.72 -0.33 2.88e-8 Gallbladder cancer; CESC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg18876405 chr7:65276391 NA 0.48 6.31 0.36 1.16e-9 Aortic root size; CESC cis rs4722166 0.573 rs35436671 chr7:22775508 G/A cg13104385 chr7:22767384 IL6 0.48 6.34 0.36 9.73e-10 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17365369 chr19:52773256 ZNF766 0.52 6.3 0.36 1.25e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00587834 chr3:51749959 GRM2 0.43 6.44 0.37 5.68e-10 Fibrinogen levels; CESC cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg04455712 chr21:45112962 RRP1B 0.38 5.83 0.34 1.57e-8 Mean corpuscular volume; CESC cis rs7666738 0.546 rs6827131 chr4:98744810 C/G cg05340658 chr4:99064831 C4orf37 0.54 6.63 0.38 1.89e-10 Colonoscopy-negative controls vs population controls; CESC cis rs36051895 0.632 rs10115962 chr9:5140841 T/C cg02405213 chr9:5042618 JAK2 -0.49 -6.21 -0.36 2.09e-9 Pediatric autoimmune diseases; CESC cis rs72945132 0.638 rs627079 chr11:70165505 G/T cg00319359 chr11:70116639 PPFIA1 0.64 6.7 0.38 1.22e-10 Coronary artery disease; CESC trans rs7937682 0.889 rs578022 chr11:111490552 G/T cg18187862 chr3:45730750 SACM1L 0.48 6.01 0.35 6.26e-9 Primary sclerosing cholangitis; CESC cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.24e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg10541313 chr22:46663664 TTC38 0.67 5.69 0.33 3.43e-8 LDL cholesterol;Cholesterol, total; CESC cis rs739401 0.611 rs417957 chr11:3046231 A/G cg25174290 chr11:3078921 CARS 0.57 8.19 0.45 1.14e-14 Longevity; CESC cis rs662064 0.963 rs10864460 chr1:10563671 C/G cg20482658 chr1:10539492 PEX14 -0.32 -6.31 -0.36 1.18e-9 Asthma; CESC cis rs1642645 0.831 rs7529102 chr1:42493322 T/C cg16685388 chr1:42384056 HIVEP3 0.37 5.61 0.33 5.2e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg27170947 chr2:26402098 FAM59B -0.87 -9.89 -0.52 7.6e-20 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00902691 chr17:75191018 SEC14L1 -0.62 -7.06 -0.4 1.49e-11 Gut microbiome composition (summer); CESC cis rs4423214 0.921 rs12807827 chr11:71203790 A/C cg05163923 chr11:71159392 DHCR7 0.8 10.79 0.55 9.45e-23 Vitamin D levels; CESC cis rs7809950 1.000 rs986994 chr7:107104115 G/T cg23024343 chr7:107201750 COG5 -0.42 -5.88 -0.34 1.22e-8 Coronary artery disease; CESC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.45 5.85 0.34 1.45e-8 Lymphocyte counts; CESC cis rs1055129 0.537 rs10852766 chr17:73951864 T/C cg08125733 chr17:73851984 WBP2 -0.48 -6.26 -0.36 1.58e-9 White matter hyperintensity burden; CESC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.79 0.34 1.96e-8 Bipolar disorder; CESC cis rs2228479 0.718 rs62054253 chr16:89896932 T/C cg00800038 chr16:89945340 TCF25 -0.85 -6.5 -0.37 3.94e-10 Skin colour saturation; CESC cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg11752832 chr7:134001865 SLC35B4 0.53 6.88 0.39 4.35e-11 Mean platelet volume; CESC cis rs9611565 0.918 rs9538 chr22:41755857 G/T cg06634786 chr22:41940651 POLR3H -0.68 -7.03 -0.4 1.78e-11 Vitiligo; CESC cis rs2404602 0.692 rs12913810 chr15:77166675 T/C cg22467129 chr15:76604101 ETFA -0.35 -5.27 -0.31 2.8e-7 Blood metabolite levels; CESC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg26119090 chr2:26468346 HADHA;HADHB -0.83 -9.25 -0.49 7.55e-18 Gut microbiome composition (summer); CESC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg02807482 chr3:125708958 NA -0.4 -5.24 -0.31 3.28e-7 Blood pressure (smoking interaction); CESC cis rs9309473 1.000 rs6710438 chr2:73820108 C/G cg20560298 chr2:73613845 ALMS1 0.53 6.78 0.38 7.95e-11 Metabolite levels; CESC cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg23711669 chr6:146136114 FBXO30 0.97 14.97 0.68 4.06e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs7103648 1.000 rs2293579 chr11:47440758 G/A cg20307385 chr11:47447363 PSMC3 0.98 16.54 0.71 1.05e-42 Diastolic blood pressure;Systolic blood pressure; CESC cis rs561341 0.825 rs2008368 chr17:30347397 T/C cg00745463 chr17:30367425 LRRC37B -0.88 -7.75 -0.43 2.01e-13 Hip circumference adjusted for BMI; CESC trans rs10500991 0.587 rs11606732 chr11:24888760 A/T cg07129253 chr8:30890560 PURG;WRN -0.5 -6.6 -0.38 2.23e-10 Iron status biomarkers; CESC cis rs2742234 1.000 rs1864399 chr10:43610455 T/C cg07801480 chr10:43725741 RASGEF1A 0.39 5.39 0.31 1.59e-7 Hirschsprung disease; CESC cis rs847577 0.609 rs705308 chr7:97695363 C/A cg21770322 chr7:97807741 LMTK2 -0.84 -15.24 -0.68 4.17e-38 Breast cancer; CESC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg23758822 chr17:41437982 NA 1.01 15.45 0.69 8.04e-39 Menopause (age at onset); CESC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg10691866 chr7:65817282 TPST1 -0.35 -5.76 -0.33 2.29e-8 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25433267 chr10:77161647 C10orf41;ZNF503 -0.51 -6.8 -0.39 6.82e-11 Fibrinogen levels; CESC cis rs10735851 1 rs10735851 chr12:53743064 G/A cg26875137 chr12:53738046 NA 0.37 5.42 0.32 1.37e-7 Total body bone mineral density; CESC cis rs4948523 0.530 rs67362351 chr10:60306548 C/A cg07615347 chr10:60278583 BICC1 -0.57 -8.14 -0.45 1.58e-14 Myopia; CESC cis rs6076065 1.000 rs2424533 chr20:23375907 C/T cg12062639 chr20:23401060 NAPB 0.41 5.16 0.3 4.95e-7 Facial morphology (factor 15, philtrum width); CESC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg05564831 chr3:52568323 NT5DC2 0.41 6.29 0.36 1.3e-9 Electroencephalogram traits; CESC cis rs4974559 0.739 rs10012819 chr4:1324758 G/C cg02980000 chr4:1222292 CTBP1 0.82 7.38 0.41 2.1e-12 Systolic blood pressure; CESC trans rs7944735 0.607 rs34895872 chr11:48021778 A/G cg03929089 chr4:120376271 NA 0.57 6.47 0.37 4.84e-10 Intraocular pressure; CESC cis rs2404602 0.692 rs35498563 chr15:76958868 C/T cg26408565 chr15:76604113 ETFA -0.4 -5.71 -0.33 3.06e-8 Blood metabolite levels; CESC cis rs2839186 0.732 rs55904887 chr21:47707811 A/G cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 7.02e-11 Testicular germ cell tumor; CESC cis rs1045902 0.967 rs1469530 chr2:73464948 C/T cg01422370 chr2:73384389 NA 0.43 7.29 0.41 3.57e-12 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23485473 chr3:52874468 TMEM110 -0.55 -6.91 -0.39 3.68e-11 Gut microbiome composition (summer); CESC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg01238044 chr22:24384105 GSTT1 0.73 8.27 0.45 6.35e-15 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs2243480 1.000 rs1715235 chr7:65488394 T/C cg13147721 chr7:65941812 NA -0.89 -8.55 -0.47 9.65e-16 Diabetic kidney disease; CESC cis rs9322193 0.884 rs9688794 chr6:149953257 C/T cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.21e-8 Lung cancer; CESC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg21280719 chr6:42927975 GNMT -0.27 -6.51 -0.37 3.67e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4319547 0.915 rs7314638 chr12:122983460 A/G cg23029597 chr12:123009494 RSRC2 -0.5 -5.52 -0.32 7.88e-8 Body mass index; CESC cis rs7937682 0.924 rs495460 chr11:111504777 G/A cg09085632 chr11:111637200 PPP2R1B -0.99 -16.01 -0.7 8.36e-41 Primary sclerosing cholangitis; CESC cis rs7216064 1.000 rs35243555 chr17:65876477 G/C cg12091567 chr17:66097778 LOC651250 -0.86 -8.82 -0.48 1.55e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg00745463 chr17:30367425 LRRC37B -0.85 -7.72 -0.43 2.36e-13 Hip circumference adjusted for BMI; CESC cis rs7089973 0.604 rs17663387 chr10:116588060 C/G cg03647239 chr10:116582469 FAM160B1 0.43 5.54 0.32 7.25e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7776786 0.934 rs13243526 chr7:18812917 C/T cg13420273 chr7:18810212 HDAC9 -0.34 -5.07 -0.3 7.44e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs10979 0.562 rs9399446 chr6:143874639 G/C cg25407410 chr6:143891975 LOC285740 -0.41 -5.68 -0.33 3.61e-8 Hypospadias; CESC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg19163074 chr7:65112434 INTS4L2 -0.46 -5.05 -0.3 8.07e-7 Aortic root size; CESC cis rs854765 0.583 rs8070128 chr17:17804725 C/T cg04398451 chr17:18023971 MYO15A 0.64 8.92 0.48 7.89e-17 Total body bone mineral density; CESC cis rs870825 0.616 rs7692104 chr4:185650895 T/G cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.74e-11 Blood protein levels; CESC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg11764359 chr7:65958608 NA 0.79 9.51 0.5 1.18e-18 Aortic root size; CESC cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg22875332 chr1:76189707 ACADM 0.65 7.61 0.42 4.8e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7072216 0.652 rs11189600 chr10:100179274 A/G cg26618903 chr10:100175079 PYROXD2 0.32 5.04 0.3 8.63e-7 Metabolite levels; CESC cis rs12410462 0.681 rs4131980 chr1:227572123 A/G cg04117972 chr1:227635322 NA 0.75 6.21 0.36 2e-9 Major depressive disorder; CESC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg17376030 chr22:41985996 PMM1 0.72 7.9 0.44 7.33e-14 Vitiligo; CESC cis rs11250464 0.755 rs11250468 chr10:1410060 A/G cg08668359 chr10:1443807 ADARB2 0.59 7.3 0.41 3.35e-12 Radiation response; CESC cis rs79387448 0.701 rs11465596 chr2:102987093 C/A cg09003973 chr2:102972529 NA 1.15 8.92 0.48 8.09e-17 Gut microbiota (bacterial taxa); CESC cis rs2299587 0.642 rs2073570 chr8:17782627 C/G cg08627089 chr8:17753878 FGL1 -0.4 -5.35 -0.31 1.94e-7 Economic and political preferences; CESC cis rs4141404 0.706 rs5753698 chr22:31970054 A/C cg13145458 chr22:31556086 RNF185 -0.5 -5.88 -0.34 1.26e-8 Paclitaxel-induced neuropathy; CESC cis rs12545109 0.837 rs6474063 chr8:57355545 C/T cg09654669 chr8:57350985 NA -0.59 -7.28 -0.41 3.76e-12 Obesity-related traits; CESC cis rs854765 0.547 rs4459604 chr17:17888549 A/G cg04398451 chr17:18023971 MYO15A -0.74 -10.53 -0.54 6.78e-22 Total body bone mineral density; CESC cis rs7160336 0.641 rs4899503 chr14:74683937 C/T cg08255017 chr14:74727001 VSX2 0.39 5.78 0.33 2.06e-8 Blood protein levels; CESC cis rs6831352 0.918 rs2602893 chr4:100044095 G/T cg12011299 chr4:100065546 ADH4 0.59 6.66 0.38 1.56e-10 Alcohol dependence; CESC cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 2e-28 Colonoscopy-negative controls vs population controls; CESC cis rs10129255 0.500 rs6576232 chr14:107195328 A/G cg07958169 chr14:107095056 NA -0.53 -8.18 -0.45 1.23e-14 Kawasaki disease; CESC cis rs9815354 1.000 rs9840532 chr3:41885697 A/G cg03022575 chr3:42003672 ULK4 0.45 5.29 0.31 2.59e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.54 6.7 0.38 1.26e-10 Prudent dietary pattern; CESC cis rs367615 0.552 rs10042721 chr5:108713970 C/T cg17395555 chr5:108820864 NA -0.44 -7.39 -0.41 1.95e-12 Colorectal cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2777491 1.000 rs1757455 chr15:41761332 G/T cg02330683 chr15:41787940 ITPKA 0.47 7.04 0.4 1.64e-11 Ulcerative colitis; CESC cis rs2645694 0.533 rs2645680 chr4:77820956 T/C cg18351406 chr4:77819688 ANKRD56 0.53 6.59 0.38 2.39e-10 Emphysema distribution in smoking; CESC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg18099408 chr3:52552593 STAB1 -0.31 -5.13 -0.3 5.6e-7 Bipolar disorder; CESC cis rs2832191 0.716 rs2692625 chr21:30446360 C/G cg08807101 chr21:30365312 RNF160 0.93 14.2 0.66 2.05e-34 Dental caries; CESC cis rs2652822 0.550 rs12593078 chr15:63517347 A/G cg02713581 chr15:63449717 RPS27L 0.49 6.06 0.35 4.59e-9 Metabolic traits; CESC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg03609598 chr5:56110824 MAP3K1 -0.49 -5.25 -0.31 3.17e-7 Initial pursuit acceleration; CESC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg26314531 chr2:26401878 FAM59B 0.57 6.55 0.37 2.94e-10 Gut microbiome composition (summer); CESC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg13902645 chr11:5959945 NA -0.68 -10.17 -0.53 9.73e-21 DNA methylation (variation); CESC cis rs9814567 1.000 rs6790466 chr3:134197740 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.11 -0.35 3.53e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg18446336 chr7:2847575 GNA12 -0.36 -5.64 -0.33 4.32e-8 Height; CESC cis rs1538970 0.774 rs67683090 chr1:45977803 T/G cg03146154 chr1:46216737 IPP 0.49 5.57 0.32 6.31e-8 Platelet count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg06646493 chr1:116519019 SLC22A15 0.47 6.31 0.36 1.18e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs117623576 0.680 rs211415 chr10:32397358 C/T cg03047570 chr10:32398778 NA 0.68 7.25 0.41 4.54e-12 Anti-saccade response; CESC cis rs10463316 0.894 rs10476769 chr5:150763970 A/G cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC cis rs854765 0.547 rs4925135 chr17:17952868 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.81 -0.48 1.7e-16 Total body bone mineral density; CESC cis rs4906332 0.966 rs12894275 chr14:103901424 A/G cg09975044 chr14:104007538 NA -0.45 -6.29 -0.36 1.31e-9 Coronary artery disease; CESC cis rs2040771 0.774 rs9604935 chr22:19211665 C/T cg02655711 chr22:19163373 SLC25A1 0.41 5.98 0.34 7.37e-9 Metabolite levels (small molecules and protein measures); CESC cis rs2281845 1.000 rs2281845 chr1:201081943 C/T cg17810781 chr1:201082982 CACNA1S 0.39 5.38 0.31 1.62e-7 Permanent tooth development; CESC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.29 0.81 1.02e-62 Prudent dietary pattern; CESC cis rs12545109 0.879 rs1513317 chr8:57372966 C/G cg09654669 chr8:57350985 NA -0.57 -6.67 -0.38 1.46e-10 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12955121 chr20:33680750 TRPC4AP -0.63 -7.27 -0.41 3.93e-12 Gut microbiome composition (summer); CESC cis rs9443645 0.507 rs1475046 chr6:79461801 G/A cg05283184 chr6:79620031 NA -0.39 -6.1 -0.35 3.68e-9 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08732623 chr10:127408269 C10orf137 0.55 6.29 0.36 1.27e-9 Gut microbiome composition (summer); CESC cis rs2304069 0.545 rs7728248 chr5:149394965 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.47 6.36 0.36 8.69e-10 HIV-1 control; CESC cis rs6426558 0.537 rs4500279 chr1:227484482 G/A cg10327440 chr1:227177885 CDC42BPA 0.48 6.06 0.35 4.74e-9 Neutrophil percentage of white cells; CESC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg08470875 chr2:26401718 FAM59B 0.65 6.89 0.39 3.98e-11 Gut microbiome composition (summer); CESC cis rs2070997 0.816 rs9695008 chr9:133720877 C/T cg11464064 chr9:133710261 ABL1 0.56 5.54 0.32 7.2e-8 Response to amphetamines; CESC cis rs2180341 0.781 rs877102 chr6:127587086 T/C cg24812749 chr6:127587940 RNF146 0.85 12.06 0.6 5.6e-27 Breast cancer; CESC cis rs2635047 0.638 rs2684840 chr18:44737230 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.45 0.32 1.18e-7 Educational attainment; CESC cis rs616402 0.527 rs11121581 chr1:10577740 A/G cg17425144 chr1:10567563 PEX14 0.39 6.28 0.36 1.34e-9 Breast size; CESC cis rs7301826 0.627 rs61937256 chr12:131302645 G/A cg11011512 chr12:131303247 STX2 -0.45 -5.49 -0.32 9.37e-8 Plasma plasminogen activator levels; CESC cis rs8072100 0.840 rs2136751 chr17:45456093 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -5.64 -0.33 4.34e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg03709012 chr19:19516395 GATAD2A 0.96 14.17 0.66 2.58e-34 Tonsillectomy; CESC cis rs4689592 0.554 rs3822270 chr4:7069804 C/A cg26116260 chr4:7069785 GRPEL1 0.99 14.45 0.66 2.63e-35 Monocyte percentage of white cells; CESC cis rs425277 0.958 rs262660 chr1:2086757 A/G cg24578937 chr1:2090814 PRKCZ 0.55 9.48 0.5 1.47e-18 Height; CESC cis rs1707322 0.752 rs28545085 chr1:46201950 G/A cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg09359103 chr1:154839909 KCNN3 -0.68 -12.36 -0.6 5.1e-28 Prostate cancer; CESC cis rs1034435 0.505 rs5768690 chr22:48902117 G/A cg05992904 chr22:48892994 FAM19A5 -0.46 -6.57 -0.37 2.64e-10 Late-onset Alzheimer's disease; CESC cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg17143192 chr8:8559678 CLDN23 -0.73 -8.93 -0.48 7.46e-17 Obesity-related traits; CESC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.73 0.47 2.88e-16 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -6.68 -0.38 1.4e-10 Total body bone mineral density; CESC cis rs2797685 0.945 rs1773138 chr1:7891797 C/T cg04725166 chr1:7887271 PER3 -0.47 -6.42 -0.37 6.44e-10 Crohn's disease; CESC cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg08645402 chr16:4508243 NA 0.42 6.06 0.35 4.64e-9 Schizophrenia; CESC cis rs6121246 0.559 rs6060922 chr20:30333909 C/T cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg25036284 chr2:26402008 FAM59B -0.57 -6.53 -0.37 3.25e-10 Gut microbiome composition (summer); CESC cis rs734999 0.505 rs4445406 chr1:2539400 T/C cg20673091 chr1:2541236 MMEL1 0.45 7.76 0.43 1.9e-13 Ulcerative colitis; CESC cis rs4971059 0.654 rs4276913 chr1:155131673 A/G cg22049894 chr1:155113146 DPM3 0.45 5.73 0.33 2.76e-8 Breast cancer; CESC cis rs17401966 1.000 rs11121532 chr1:10277898 G/T cg15208524 chr1:10270712 KIF1B 0.51 6.64 0.38 1.78e-10 Hepatocellular carcinoma; CESC cis rs897984 0.721 rs28360557 chr16:30983260 A/C cg02466173 chr16:30829666 NA 0.47 7.96 0.44 4.96e-14 Dementia with Lewy bodies; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg27305525 chr1:154955752 FLAD1 0.46 6.01 0.35 6.07e-9 Systemic lupus erythematosus; CESC cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg25517755 chr10:38738941 LOC399744 -0.47 -6.08 -0.35 4.08e-9 Extrinsic epigenetic age acceleration; CESC cis rs711830 1.000 rs2113559 chr2:177031099 A/G cg13092806 chr2:177043255 NA 0.85 11.04 0.56 1.49e-23 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CESC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg26314531 chr2:26401878 FAM59B -0.85 -8.89 -0.48 9.94e-17 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.08 0.3 7.02e-7 Personality dimensions; CESC cis rs11122272 0.675 rs1416913 chr1:231533206 A/C cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs66573146 1.000 rs6812391 chr4:6963893 G/A cg00086871 chr4:6988644 TBC1D14 1.16 6.56 0.37 2.82e-10 Granulocyte percentage of myeloid white cells; CESC cis rs8005677 0.611 rs11624528 chr14:23459156 A/G cg23176270 chr14:23476067 C14orf93 0.45 5.45 0.32 1.13e-7 Cognitive ability (multi-trait analysis); CESC trans rs2727020 0.734 rs1164664 chr11:49295542 T/G cg03929089 chr4:120376271 NA 0.68 8.49 0.46 1.48e-15 Coronary artery disease; CESC cis rs16858210 0.837 rs11716104 chr3:183581999 G/C cg03417191 chr3:183542750 MAP6D1 -0.45 -5.72 -0.33 2.92e-8 Menopause (age at onset); CESC cis rs1003719 0.788 rs4572679 chr21:38453227 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.67 0.47 4.41e-16 Eye color traits; CESC cis rs7640424 0.649 rs17233248 chr3:107899513 T/C cg09227934 chr3:107805635 CD47 -0.45 -5.82 -0.34 1.66e-8 Body mass index; CESC cis rs5769765 0.955 rs8139758 chr22:50261123 G/T cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs1355223 0.583 rs2941058 chr11:34880245 C/G cg11058730 chr11:34937778 PDHX;APIP 0.84 13.21 0.63 5.91e-31 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs11577318 0.853 rs7537477 chr1:26618829 C/T cg18121669 chr1:26560928 CCDC21 0.43 5.12 0.3 5.78e-7 Granulocyte percentage of myeloid white cells; CESC cis rs6938 0.534 rs11854704 chr15:75221015 C/T cg14664628 chr15:75095509 CSK -0.57 -7.48 -0.42 1.11e-12 Breast cancer; CESC cis rs921968 0.541 rs10205073 chr2:219412784 C/A cg02176678 chr2:219576539 TTLL4 -0.55 -9.98 -0.52 4.06e-20 Mean corpuscular hemoglobin concentration; CESC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg11859384 chr17:80120422 CCDC57 0.42 5.7 0.33 3.17e-8 Life satisfaction; CESC cis rs7084402 0.967 rs1427223 chr10:60290966 T/C cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.31e-18 Refractive error; CESC cis rs9788682 0.633 rs2656070 chr15:78730252 A/G cg24631222 chr15:78858424 CHRNA5 -0.63 -7.56 -0.42 6.53e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs10754283 0.871 rs72712569 chr1:90125657 G/C cg21401794 chr1:90099060 LRRC8C -0.64 -8.24 -0.45 8.17e-15 Amyotrophic lateral sclerosis (sporadic); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03016991 chr12:109124380 CORO1C -0.57 -6.62 -0.38 1.94e-10 Gut microbiome composition (summer); CESC cis rs28655083 0.956 rs8060627 chr16:77077065 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.4 -5.25 -0.31 3.17e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7312933 0.510 rs1907705 chr12:42451122 T/A cg01256987 chr12:42539512 GXYLT1 -0.44 -6.68 -0.38 1.42e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs728616 0.614 rs61859199 chr10:82118613 G/T cg05935833 chr10:81318306 SFTPA2 -0.46 -5.84 -0.34 1.53e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6693567 0.565 rs6685252 chr1:150259945 T/A cg09579323 chr1:150459698 TARS2 -0.45 -5.84 -0.34 1.52e-8 Migraine; CESC cis rs66530629 0.917 rs9259 chr1:25168124 C/G cg22509179 chr1:25234806 RUNX3 -0.38 -5.14 -0.3 5.43e-7 Plateletcrit; CESC cis rs7089973 0.604 rs7095816 chr10:116585109 T/C cg25233709 chr10:116636983 FAM160B1 0.35 5.74 0.33 2.59e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs11871801 0.918 rs34527783 chr17:40568094 A/G cg21433558 chr17:40837037 CNTNAP1 0.46 5.03 0.3 9.08e-7 Crohn's disease; CESC cis rs7267979 0.739 rs6138555 chr20:25242910 G/A cg08601574 chr20:25228251 PYGB 0.4 5.58 0.32 5.86e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg00149659 chr3:10157352 C3orf10 0.77 9.66 0.51 4.22e-19 Alzheimer's disease; CESC cis rs863345 0.604 rs12078065 chr1:158465063 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs11098499 0.697 rs28655325 chr4:120372999 A/G cg24375607 chr4:120327624 NA 0.46 5.77 0.33 2.17e-8 Corneal astigmatism; CESC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg07507251 chr3:52567010 NT5DC2 0.42 7.29 0.41 3.61e-12 Bipolar disorder; CESC cis rs3796352 1.000 rs35576914 chr3:53092270 G/A cg12962167 chr3:53033115 SFMBT1 0.7 6.13 0.35 3.23e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs887829 0.569 rs3755319 chr2:234667582 A/C cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.35 5.17 0.3 4.55e-7 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC trans rs208520 0.874 rs208515 chr6:66945749 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.86 -9.92 -0.52 6.4e-20 Exhaled nitric oxide output; CESC cis rs11229030 0.893 rs2264054 chr11:57209488 G/A cg00522883 chr11:57194120 SLC43A3 -0.48 -6.38 -0.36 8.04e-10 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11430096 chr6:110968061 CDK19 -0.56 -6.45 -0.37 5.36e-10 Gut microbiome composition (summer); CESC cis rs73110464 0.609 rs727266 chr12:53356411 C/T cg05393297 chr12:53359155 NA -0.71 -10.27 -0.53 4.78e-21 Cancer (pleiotropy); CESC cis rs782590 0.837 rs782584 chr2:55921116 C/G cg18811423 chr2:55921094 PNPT1 -0.82 -14.1 -0.65 4.63e-34 Metabolic syndrome; CESC trans rs1814175 0.817 rs7946556 chr11:49944874 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -20.29 -0.78 7.13e-56 Height; CESC cis rs7208859 0.623 rs12006 chr17:29110652 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2404602 0.692 rs58973160 chr15:77000342 T/C cg26408565 chr15:76604113 ETFA -0.39 -5.54 -0.32 7.14e-8 Blood metabolite levels; CESC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg17949981 chr6:28129498 ZNF389 0.44 5.53 0.32 7.84e-8 Depression; CESC cis rs72829446 0.530 rs8071847 chr17:7407327 A/G cg02795151 chr17:7402630 POLR2A 0.6 6.56 0.37 2.83e-10 Androgen levels; CESC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.42 -5.4 -0.31 1.51e-7 Tonsillectomy; CESC cis rs10791097 0.739 rs11222358 chr11:130730497 G/A cg12179176 chr11:130786555 SNX19 0.55 8.05 0.44 2.81e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg22963979 chr7:1858916 MAD1L1 -0.43 -5.85 -0.34 1.43e-8 Bipolar disorder and schizophrenia; CESC cis rs6967414 0.786 rs7804259 chr7:6755448 C/G cg00387323 chr7:6746715 ZNF12 0.62 5.69 0.33 3.43e-8 Hematocrit;Hemoglobin concentration; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg03533382 chr5:126853128 PRRC1 0.49 6.45 0.37 5.27e-10 Weight; CESC cis rs11098499 0.863 rs3775849 chr4:120450908 G/C cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs9470366 0.509 rs4713996 chr6:36629714 C/T cg08179530 chr6:36648295 CDKN1A -0.62 -9.36 -0.5 3.66e-18 QRS duration; CESC cis rs3008870 0.536 rs2208576 chr1:67513401 C/G cg08660285 chr1:67390436 MIER1;WDR78 -0.41 -5.28 -0.31 2.71e-7 Lymphocyte percentage of white cells; CESC cis rs477692 0.905 rs4751106 chr10:131424653 G/T cg05714579 chr10:131428358 MGMT -0.58 -8.26 -0.45 6.85e-15 Response to temozolomide; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25141720 chr9:89561826 GAS1 0.5 6.28 0.36 1.37e-9 Gut microbiota (bacterial taxa); CESC cis rs9359856 0.564 rs76069351 chr6:90425043 C/T cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.86 -0.34 1.38e-8 Bipolar disorder; CESC cis rs4974559 0.739 rs1250121 chr4:1263521 A/G cg02980000 chr4:1222292 CTBP1 -0.74 -7.78 -0.43 1.59e-13 Systolic blood pressure; CESC cis rs9287719 0.746 rs6742448 chr2:10759126 G/A cg00105475 chr2:10696890 NA 0.35 5.07 0.3 7.65e-7 Prostate cancer; CESC cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg20503657 chr10:835505 NA 0.83 8.51 0.46 1.3e-15 Eosinophil percentage of granulocytes; CESC cis rs4523957 0.928 rs10852932 chr17:2143460 G/T cg16513277 chr17:2031491 SMG6 -0.6 -8.15 -0.45 1.48e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg12463550 chr7:65579703 CRCP 0.49 6.18 0.35 2.46e-9 Aortic root size; CESC cis rs2880765 0.805 rs34598679 chr15:86042205 G/A cg10818794 chr15:86012489 AKAP13 -0.34 -5.26 -0.31 3.02e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01565083 chr17:80042523 FASN -0.63 -7.29 -0.41 3.53e-12 Gut microbiome composition (summer); CESC cis rs6674176 0.597 rs3762422 chr1:44400532 T/A cg23954153 chr1:44402353 ARTN -0.37 -5.94 -0.34 8.94e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9790314 0.586 rs11713185 chr3:161111357 C/G cg03342759 chr3:160939853 NMD3 -0.43 -5.6 -0.33 5.46e-8 Morning vs. evening chronotype; CESC cis rs4654899 0.785 rs12070677 chr1:21337322 A/G cg05370193 chr1:21551575 ECE1 0.38 5.84 0.34 1.55e-8 Superior frontal gyrus grey matter volume; CESC trans rs11039798 1.000 rs12280020 chr11:48618844 G/C cg15704280 chr7:45808275 SEPT13 0.65 6.28 0.36 1.39e-9 Axial length; CESC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.42 -5.4 -0.31 1.51e-7 Tonsillectomy; CESC cis rs12136530 0.577 rs12066114 chr1:19792527 A/G cg01832549 chr1:19774989 CAPZB -0.39 -5.54 -0.32 7.36e-8 Lead levels in blood; CESC cis rs8141529 0.764 rs5762824 chr22:29222930 C/T cg15103426 chr22:29168792 CCDC117 0.68 9.65 0.51 4.52e-19 Lymphocyte counts; CESC cis rs9309473 0.500 rs13022837 chr2:73912567 T/A cg20560298 chr2:73613845 ALMS1 0.52 7.24 0.41 4.84e-12 Metabolite levels; CESC trans rs12229918 0.540 rs10784460 chr12:65863584 C/T cg16723182 chr1:148753544 NBPF16 0.48 6.1 0.35 3.83e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10538494 chr14:97263716 VRK1 0.6 7.08 0.4 1.26e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06996663 chr8:54756036 ATP6V1H 0.51 6.03 0.35 5.52e-9 Gut microbiome composition (summer); CESC cis rs9291683 0.632 rs13101785 chr4:10042915 T/A cg02734326 chr4:10020555 SLC2A9 0.47 6.53 0.37 3.29e-10 Bone mineral density; CESC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg02896835 chr1:92012615 NA -0.53 -6.82 -0.39 6.09e-11 Breast cancer; CESC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.63e-16 Initial pursuit acceleration; CESC cis rs6032067 0.641 rs17423416 chr20:43758144 G/T cg10761708 chr20:43804764 PI3 0.5 5.25 0.31 3.12e-7 Blood protein levels; CESC cis rs77861329 1.000 rs9847073 chr3:52144947 C/T cg08692210 chr3:52188851 WDR51A -0.82 -7.21 -0.4 6.02e-12 Macrophage inflammatory protein 1b levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18502522 chr15:75165624 SCAMP2 -0.41 -6.24 -0.36 1.74e-9 Gambling; CESC cis rs9302635 0.626 rs34508528 chr16:72215115 C/T cg01557791 chr16:72042693 DHODH -0.74 -7.69 -0.43 2.89e-13 Blood protein levels; CESC cis rs637571 0.584 rs659824 chr11:65636509 A/G cg26695010 chr11:65641043 EFEMP2 0.51 6.35 0.36 9.23e-10 Eosinophil percentage of white cells; CESC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg06481639 chr22:41940642 POLR3H 0.59 5.85 0.34 1.45e-8 Vitiligo; CESC cis rs11030122 0.632 rs4910596 chr11:4084604 A/G cg18678763 chr11:4115507 RRM1 -0.51 -6.87 -0.39 4.56e-11 Mean platelet volume;Platelet distribution width; CESC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg03351412 chr1:154909251 PMVK 0.55 6.82 0.39 5.99e-11 Prostate cancer; CESC cis rs4072980 0.524 rs28477803 chr1:38398694 C/T cg18451016 chr1:38461880 NA 0.42 6.06 0.35 4.65e-9 Coronary artery disease; CESC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg17971929 chr21:40555470 PSMG1 -0.88 -12.71 -0.62 3.15e-29 Cognitive function; CESC cis rs46522 0.585 rs79049364 chr17:47014991 T/A cg16584676 chr17:46985605 UBE2Z 0.49 5.87 0.34 1.31e-8 Coronary heart disease; CESC cis rs9487051 0.646 rs9487049 chr6:109615905 A/T cg01475377 chr6:109611718 NA -0.39 -5.39 -0.31 1.55e-7 Reticulocyte fraction of red cells; CESC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg11168104 chr5:1857477 NA -0.41 -6.12 -0.35 3.34e-9 Cardiovascular disease risk factors; CESC cis rs9911578 1.000 rs8079774 chr17:56908188 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis); CESC cis rs7089973 0.604 rs11196939 chr10:116593175 A/G cg23260525 chr10:116636907 FAM160B1 -0.37 -6.45 -0.37 5.25e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs559928 0.606 rs11231726 chr11:63987339 C/T cg18225595 chr11:63971243 STIP1 0.67 6.02 0.35 5.73e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs896854 0.902 rs726816 chr8:95968413 T/G cg26343298 chr8:95960752 TP53INP1 0.34 5.33 0.31 2.15e-7 Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16444294 chr16:28925790 RABEP2 0.44 6.26 0.36 1.56e-9 Fibrinogen levels; CESC cis rs9303401 0.659 rs17741087 chr17:56550300 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.98 11.87 0.59 2.46e-26 Cognitive test performance; CESC cis rs10832963 0.961 rs10832954 chr11:18643559 G/A cg09201001 chr11:18656081 SPTY2D1 0.82 12.36 0.6 5.21e-28 Breast cancer; CESC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg11941060 chr3:133502564 NA -0.46 -6.11 -0.35 3.45e-9 Iron status biomarkers; CESC cis rs72792276 1.000 rs72794370 chr5:127444907 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.65 5.18 0.3 4.47e-7 Red cell distribution width; CESC trans rs1945213 0.694 rs34537090 chr11:55843285 G/C cg03929089 chr4:120376271 NA 0.7 6.69 0.38 1.35e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs26868 0.742 rs26848 chr16:2263516 A/G cg02248941 chr16:2239361 CASKIN1 0.42 7.07 0.4 1.37e-11 Height; CESC cis rs73001065 0.792 rs17216588 chr19:19664077 C/T cg03709012 chr19:19516395 GATAD2A 0.97 5.89 0.34 1.18e-8 LDL cholesterol; CESC cis rs6502050 0.835 rs7502078 chr17:80131879 C/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.47 -0.37 4.67e-10 Life satisfaction; CESC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 11.2 0.57 4.36e-24 Platelet count; CESC cis rs9814567 0.806 rs6806810 chr3:134323522 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.38 -5.06 -0.3 7.86e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04347867 chr16:56965804 HERPUD1 -0.41 -6.27 -0.36 1.47e-9 Gambling; CESC cis rs7208859 0.573 rs11654035 chr17:29136426 T/C cg13385521 chr17:29058706 SUZ12P 0.84 6.62 0.38 1.98e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1950626 0.833 rs12891189 chr14:101415523 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.79 10.67 0.55 2.42e-22 Pelvic organ prolapse (moderate/severe); CESC cis rs6580649 0.941 rs72644843 chr12:48465061 A/G cg24011408 chr12:48396354 COL2A1 -0.41 -5.27 -0.31 2.86e-7 Lung cancer; CESC cis rs7546094 1.000 rs10857963 chr1:113091487 C/T cg22162597 chr1:113214053 CAPZA1 0.38 5.77 0.33 2.22e-8 Platelet distribution width; CESC cis rs2230307 0.536 rs6577152 chr1:100434610 A/G cg24955406 chr1:100503596 HIAT1 0.56 5.61 0.33 5.15e-8 Carotid intima media thickness; CESC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg26314531 chr2:26401878 FAM59B -0.59 -6.74 -0.38 9.88e-11 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg12963246 chr6:28129442 ZNF389 -0.51 -6.8 -0.39 6.82e-11 Depression; CESC cis rs9790314 1.000 rs3849524 chr3:161015589 C/T cg04691961 chr3:161091175 C3orf57 -0.47 -6.17 -0.35 2.58e-9 Morning vs. evening chronotype; CESC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg13906792 chr15:75199810 C15orf17 -0.34 -5.18 -0.3 4.47e-7 Breast cancer; CESC cis rs11997175 0.646 rs6984073 chr8:33700070 G/A ch.8.33884649F chr8:33765107 NA 0.56 7.34 0.41 2.56e-12 Body mass index; CESC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs889398 0.771 rs8048550 chr16:69891759 T/G cg09409435 chr16:70099608 PDXDC2 0.42 5.27 0.31 2.9e-7 Body mass index; CESC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg14829155 chr15:31115871 NA 0.78 10.92 0.56 3.52e-23 Huntington's disease progression; CESC trans rs11722228 0.522 rs1109472 chr4:10134448 C/G cg26043149 chr18:55253948 FECH 0.96 12.78 0.62 1.91e-29 Gout;Urate levels;Serum uric acid levels; CESC cis rs9309473 1.000 rs7594511 chr2:73681639 A/G cg20560298 chr2:73613845 ALMS1 -0.54 -7.1 -0.4 1.14e-11 Metabolite levels; CESC cis rs5758511 0.508 rs2854827 chr22:42461918 G/A cg00645731 chr22:42541494 CYP2D7P1 0.49 7.12 0.4 1.01e-11 Birth weight; CESC cis rs796364 1.000 rs11694369 chr2:200741720 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.82 -6.31 -0.36 1.14e-9 Schizophrenia; CESC cis rs1707322 0.721 rs11211165 chr1:46157906 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.63 0.42 4.11e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4853012 0.887 rs6737314 chr2:74339586 A/G cg19729930 chr2:74357872 NA 0.77 10.52 0.54 7.52e-22 Gestational age at birth (maternal effect); CESC cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg03060546 chr3:49711283 APEH 0.52 6.31 0.36 1.17e-9 Parkinson's disease; CESC cis rs11587400 0.593 rs2336365 chr1:115175415 G/T cg12756093 chr1:115239321 AMPD1 -0.42 -5.69 -0.33 3.28e-8 Autism; CESC cis rs6502050 0.835 rs4789668 chr17:80161990 C/T cg23985595 chr17:80112537 CCDC57 -0.4 -6.48 -0.37 4.35e-10 Life satisfaction; CESC cis rs12545109 0.842 rs2582379 chr8:57395243 C/T cg09654669 chr8:57350985 NA 0.61 6.93 0.39 3.18e-11 Obesity-related traits; CESC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg26314531 chr2:26401878 FAM59B -0.61 -6.94 -0.39 2.97e-11 Gut microbiome composition (summer); CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25073725 chr4:100010060 ADH5 0.49 5.06 0.3 7.85e-7 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21005948 chr18:46065258 KIAA0427 -0.44 -6.36 -0.36 8.94e-10 Fibrinogen levels; CESC cis rs2832191 0.716 rs1888439 chr21:30454457 A/G cg08807101 chr21:30365312 RNF160 0.91 13.95 0.65 1.49e-33 Dental caries; CESC cis rs477692 0.935 rs568918 chr10:131414455 A/G cg05714579 chr10:131428358 MGMT 0.5 7.01 0.4 2.02e-11 Response to temozolomide; CESC cis rs941408 1.000 rs1736176 chr19:2790394 G/A cg00079169 chr19:2811669 THOP1 0.45 6.36 0.36 8.56e-10 Total cholesterol levels; CESC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg10494973 chr17:80897199 TBCD -0.49 -5.75 -0.33 2.42e-8 Breast cancer; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg16754766 chr12:42877927 PRICKLE1 0.59 6.63 0.38 1.89e-10 Psoriatic arthritis; CESC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg16405210 chr4:1374714 KIAA1530 -0.48 -6.09 -0.35 3.96e-9 Obesity-related traits; CESC cis rs2519796 0.531 rs2519104 chr9:136805973 G/A cg13751417 chr9:136814406 VAV2 -0.43 -5.67 -0.33 3.79e-8 Hematocrit;Hemoglobin concentration; CESC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg27266027 chr21:40555129 PSMG1 0.46 5.49 0.32 9.23e-8 Cognitive function; CESC cis rs7223966 0.921 rs11655493 chr17:61733052 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.62 0.38 2.03e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg25767906 chr1:53392781 SCP2 -0.56 -7.4 -0.41 1.8e-12 Monocyte count; CESC cis rs1152591 0.643 rs3020449 chr14:64773392 C/T cg23250157 chr14:64679961 SYNE2 -0.42 -5.56 -0.32 6.47e-8 Atrial fibrillation; CESC cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg25019033 chr10:957182 NA -0.59 -5.94 -0.34 9.09e-9 Eosinophil percentage of granulocytes; CESC cis rs66887589 0.837 rs6534135 chr4:120406302 A/G cg09307838 chr4:120376055 NA 0.53 7.12 0.4 1.04e-11 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00301775 chr5:40798454 PRKAA1 -0.54 -6.4 -0.37 7.2e-10 Gut microbiome composition (summer); CESC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg17143192 chr8:8559678 CLDN23 0.76 8.9 0.48 9.21e-17 Obesity-related traits; CESC cis rs2370759 1.000 rs11594963 chr10:32625736 G/A cg05361325 chr10:32636312 EPC1 -0.55 -5.04 -0.3 8.59e-7 Sexual dysfunction (female); CESC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg16545954 chr1:2118288 C1orf86 -0.34 -6.35 -0.36 9.49e-10 Height; CESC cis rs7727544 0.735 rs272894 chr5:131662460 C/T cg24060327 chr5:131705240 SLC22A5 -0.68 -9.01 -0.48 4.2e-17 Blood metabolite levels; CESC cis rs17384381 0.953 rs12138621 chr1:85783970 T/C cg16011679 chr1:85725395 C1orf52 0.78 7.92 0.44 6.43e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs763121 0.889 rs6001209 chr22:39121252 C/T cg14440974 chr22:39074834 NA 0.4 5.43 0.32 1.25e-7 Menopause (age at onset); CESC cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg05340658 chr4:99064831 C4orf37 0.77 11.73 0.58 7.21e-26 Colonoscopy-negative controls vs population controls; CESC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg05754148 chr16:3507555 NAT15 0.57 8.16 0.45 1.33e-14 Tuberculosis; CESC cis rs77741769 0.571 rs11065292 chr12:121289155 T/C cg02419362 chr12:121203948 SPPL3 0.34 5.55 0.32 7.07e-8 Mean corpuscular volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03346442 chr12:117316882 HRK -0.53 -6.41 -0.37 6.56e-10 Ulcerative colitis; CESC cis rs2243480 1.000 rs35058610 chr7:65390925 G/A cg13147721 chr7:65941812 NA -0.85 -8.1 -0.45 2e-14 Diabetic kidney disease; CESC cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg24920358 chr1:40204285 PPIE 0.41 6.1 0.35 3.84e-9 Blood protein levels; CESC cis rs9858542 0.953 rs6446264 chr3:49417243 C/A cg07274523 chr3:49395745 GPX1 0.67 8.37 0.46 3.46e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs727505 0.607 rs67673811 chr7:124802694 C/G cg23710748 chr7:124431027 NA -0.4 -6.21 -0.36 2.04e-9 Lewy body disease; CESC cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg18131467 chr2:239335373 ASB1 0.94 14.13 0.66 3.57e-34 Multiple system atrophy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04550740 chr15:52821405 MYO5A -0.47 -6.42 -0.37 6.17e-10 Gut microbiota (bacterial taxa); CESC cis rs8017423 0.935 rs2236403 chr14:90736325 C/T cg14092571 chr14:90743983 NA 0.54 8.26 0.45 7.21e-15 Mortality in heart failure; CESC cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg16339924 chr4:17578868 LAP3 0.74 9.68 0.51 3.59e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg16325326 chr1:53192061 ZYG11B 0.94 16.51 0.71 1.35e-42 Monocyte count; CESC cis rs7520050 1.000 rs12410070 chr1:46358882 T/C cg03146154 chr1:46216737 IPP -0.46 -5.86 -0.34 1.36e-8 Red blood cell count;Reticulocyte count; CESC cis rs8114671 0.562 rs6087644 chr20:33480917 G/C cg07148914 chr20:33460835 GGT7 0.51 6.56 0.37 2.85e-10 Height; CESC cis rs12410462 1.000 rs6672162 chr1:227632335 G/A cg04117972 chr1:227635322 NA 0.64 6.48 0.37 4.36e-10 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23019286 chr1:227728774 NA -0.61 -7.82 -0.43 1.27e-13 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs28867087 chr4:98880349 T/A cg05340658 chr4:99064831 C4orf37 0.78 11.7 0.58 9.27e-26 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04879577 chr6:90121826 RRAGD 0.57 6.2 0.36 2.15e-9 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.09 -12.46 -0.61 2.41e-28 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10294252 chr15:74912474 CLK3 0.42 6.03 0.35 5.59e-9 Fibrinogen levels; CESC cis rs11098499 0.865 rs1112817 chr4:120297800 T/C cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg21280719 chr6:42927975 GNMT 0.3 6.81 0.39 6.56e-11 Alzheimer's disease in APOE e4+ carriers; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg13325346 chr17:37353483 CACNB1 -0.43 -6.04 -0.35 5.26e-9 Asthma; CESC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg03351412 chr1:154909251 PMVK 0.69 9.25 0.49 7.88e-18 Prostate cancer; CESC cis rs9303401 0.614 rs35308719 chr17:57163501 C/T cg12560992 chr17:57184187 TRIM37 0.51 5.25 0.31 3.19e-7 Cognitive test performance; CESC cis rs67311347 0.866 rs2371183 chr3:40334247 C/T cg01475735 chr3:40494733 NA 0.39 5.03 0.3 9e-7 Renal cell carcinoma; CESC cis rs6445797 0.632 rs2054987 chr3:56593105 G/C cg13792233 chr3:56591045 CCDC66 0.39 5.07 0.3 7.5e-7 Gastritis; CESC cis rs7020830 0.867 rs13301916 chr9:37361455 A/C cg14294708 chr9:37120828 ZCCHC7 1.14 20.49 0.78 1.39e-56 Schizophrenia; CESC cis rs35740288 0.721 rs4843093 chr15:86237433 G/A cg20737812 chr15:86336631 KLHL25 -0.37 -5.03 -0.3 8.94e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC trans rs4862750 0.914 rs11943333 chr4:187872455 A/G cg19305040 chr4:184580401 C4orf41;RWDD4A -0.48 -6.37 -0.36 8.39e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs400736 0.930 rs226249 chr1:8021778 A/G cg25007680 chr1:8021821 PARK7 0.7 10.13 0.53 1.36e-20 Response to antidepressants and depression; CESC cis rs7927771 1.000 rs4752857 chr11:47655752 C/T cg05585544 chr11:47624801 NA -0.53 -8.41 -0.46 2.57e-15 Subjective well-being; CESC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.53 -0.42 7.92e-13 Gut microbiome composition (summer); CESC cis rs858239 0.509 rs6962213 chr7:23188109 G/A cg23682824 chr7:23144976 KLHL7 0.49 6.51 0.37 3.84e-10 Cerebrospinal fluid biomarker levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12843872 chr7:90894352 FZD1 0.5 6.79 0.38 7.23e-11 Systemic lupus erythematosus; CESC cis rs864643 0.773 rs11129837 chr3:39589963 A/G cg13882414 chr3:39194867 CSRNP1 0.44 5.55 0.32 6.82e-8 Attention deficit hyperactivity disorder; CESC cis rs7523050 0.730 rs35100394 chr1:109433989 C/G cg08274380 chr1:109419600 GPSM2 0.91 6.41 0.37 6.51e-10 Fat distribution (HIV); CESC cis rs727505 0.721 rs67277928 chr7:124776704 G/T cg23710748 chr7:124431027 NA -0.34 -5.67 -0.33 3.72e-8 Lewy body disease; CESC cis rs8017423 0.935 rs11621820 chr14:90727154 C/T cg14092571 chr14:90743983 NA -0.55 -8.33 -0.46 4.46e-15 Mortality in heart failure; CESC cis rs6714710 0.603 rs34503448 chr2:98587288 A/G cg26665480 chr2:98280029 ACTR1B 0.66 8.95 0.48 6.21e-17 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs6964587 0.967 rs7781221 chr7:91664645 A/G cg17063962 chr7:91808500 NA 0.6 8.31 0.45 4.96e-15 Breast cancer; CESC cis rs2249694 0.960 rs9630033 chr10:135418505 G/T cg19469447 chr10:135341870 CYP2E1 0.37 5.21 0.3 3.76e-7 Obesity-related traits; CESC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg04553112 chr3:125709451 NA -0.55 -5.82 -0.34 1.71e-8 Blood pressure (smoking interaction); CESC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs9868809 0.764 rs2633958 chr3:48635432 A/G cg00383909 chr3:49044727 WDR6 -0.73 -5.52 -0.32 8.05e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs2243480 1.000 rs1638734 chr7:66097539 A/C cg12463550 chr7:65579703 CRCP 0.75 5.85 0.34 1.42e-8 Diabetic kidney disease; CESC cis rs9916302 0.706 rs4794808 chr17:37531916 C/T cg07936489 chr17:37558343 FBXL20 0.9 9.82 0.52 1.27e-19 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4523957 0.583 rs2760743 chr17:2017079 A/C cg16513277 chr17:2031491 SMG6 0.72 10.18 0.53 9.13e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4803468 1.000 rs3213861 chr19:41919944 A/C cg14132834 chr19:41945861 ATP5SL -0.67 -8.23 -0.45 8.57e-15 Height; CESC cis rs7223966 1.000 rs11542436 chr17:61778689 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.68 0.38 1.44e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2688608 0.620 rs7098444 chr10:75580042 C/T cg23231163 chr10:75533350 FUT11 -0.33 -5.03 -0.3 8.86e-7 Inflammatory bowel disease; CESC cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg20503657 chr10:835505 NA 1.08 10.04 0.53 2.52e-20 Eosinophil percentage of granulocytes; CESC cis rs17376456 1.000 rs58734583 chr5:93532155 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.33 0.31 2.14e-7 Diabetic retinopathy; CESC cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6088590 0.561 rs11167239 chr20:33140472 G/A cg06115741 chr20:33292138 TP53INP2 0.51 6.54 0.37 3.21e-10 Coronary artery disease; CESC cis rs6449957 0.639 rs251398 chr5:67509801 C/T cg23036683 chr5:67512108 NA -0.44 -6.08 -0.35 4.19e-9 Cleft lip with or without cleft palate; CESC cis rs10779751 0.734 rs2259886 chr1:11137778 C/T cg08854313 chr1:11322531 MTOR 0.79 11.01 0.56 1.87e-23 Body mass index; CESC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg07936489 chr17:37558343 FBXL20 0.77 10.42 0.54 1.51e-21 Glomerular filtration rate (creatinine); CESC cis rs798766 0.953 rs798751 chr4:1719572 A/G cg05874882 chr4:1763078 NA -0.61 -8.52 -0.46 1.19e-15 Bladder cancer;Urinary bladder cancer; CESC cis rs6665290 0.904 rs6690803 chr1:227189106 C/T cg10327440 chr1:227177885 CDC42BPA -1.15 -29.58 -0.88 6e-86 Myeloid white cell count; CESC cis rs9457247 0.602 rs12208359 chr6:167458455 G/A cg07741184 chr6:167504864 NA 0.37 6.45 0.37 5.33e-10 Crohn's disease; CESC cis rs72781680 0.716 rs2712065 chr2:23973603 C/T cg08917208 chr2:24149416 ATAD2B -0.57 -5.74 -0.33 2.62e-8 Lymphocyte counts; CESC cis rs644799 0.511 rs1016030 chr11:95472693 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.66 9.23 0.49 8.69e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11758351 0.660 rs55848726 chr6:26224434 T/C cg23601095 chr6:26197514 HIST1H3D 0.91 9.96 0.52 4.64e-20 Gout;Renal underexcretion gout; CESC cis rs7219021 0.886 rs3887854 chr17:46868710 A/G cg16584676 chr17:46985605 UBE2Z 0.57 6.46 0.37 5.01e-10 Schizophrenia or bipolar disorder; CESC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg02161503 chr7:157955692 PTPRN2 0.43 7.72 0.43 2.42e-13 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs17095355 1.000 rs1376111 chr10:111707255 C/T cg00817464 chr10:111662876 XPNPEP1 -0.45 -5.4 -0.31 1.51e-7 Biliary atresia; CESC cis rs7635838 0.826 rs9867963 chr3:11469126 C/T cg00170343 chr3:11313890 ATG7 0.45 5.95 0.34 8.26e-9 HDL cholesterol; CESC cis rs7680126 0.500 rs11735668 chr4:10148655 C/G cg11266682 chr4:10021025 SLC2A9 -0.5 -6.48 -0.37 4.42e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg18230493 chr5:56204884 C5orf35 0.61 7.97 0.44 4.79e-14 Initial pursuit acceleration; CESC cis rs4727963 0.846 rs1554700 chr7:122739121 T/C cg03640110 chr7:122635026 TAS2R16 -0.36 -5.61 -0.33 5.12e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg17330251 chr7:94953956 PON1 -0.56 -9.23 -0.49 9.23e-18 Paraoxonase activity; CESC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg13880726 chr7:1868755 MAD1L1 0.41 5.39 0.31 1.54e-7 Bipolar disorder and schizophrenia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19465159 chr13:112631672 NA -0.46 -6.45 -0.37 5.42e-10 Systemic lupus erythematosus; CESC cis rs3820068 0.603 rs72645887 chr1:15929905 G/C cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs3733585 0.699 rs6844316 chr4:9958977 A/G cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1448094 0.511 rs56291271 chr12:86162287 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.59 0.32 5.75e-8 Major depressive disorder; CESC cis rs116095464 0.558 rs55776650 chr5:273826 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.42 0.32 1.31e-7 Breast cancer; CESC cis rs79976124 0.879 rs17432710 chr6:66621744 T/C cg07460842 chr6:66804631 NA 0.75 8.72 0.47 3.21e-16 Type 2 diabetes; CESC cis rs2617583 0.935 rs1354139 chr5:1451782 T/C cg07151155 chr5:1473589 LPCAT1 -0.33 -5.06 -0.3 7.93e-7 Breast cancer; CESC cis rs2735413 0.670 rs4522431 chr16:78111152 C/T cg04733911 chr16:78082701 NA 0.4 5.69 0.33 3.4e-8 Systolic blood pressure (alcohol consumption interaction); CESC cis rs61931739 0.500 rs11053290 chr12:34582392 C/T cg23762105 chr12:34175262 ALG10 0.4 5.17 0.3 4.62e-7 Morning vs. evening chronotype; CESC cis rs2235544 0.579 rs11804837 chr1:54482915 G/A cg09175620 chr1:54484536 LDLRAD1 -0.28 -5.12 -0.3 5.76e-7 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC trans rs2391518 0.639 rs2968999 chr4:130784545 G/A cg24601559 chr2:43328536 NA 0.35 6.02 0.35 5.87e-9 Body mass index; CESC cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg03433033 chr1:76189801 ACADM 0.68 8.1 0.45 1.98e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7829975 0.782 rs6990746 chr8:8547811 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.0 -0.35 6.38e-9 Mood instability; CESC cis rs9398803 0.897 rs9398804 chr6:126703390 T/A cg19875578 chr6:126661172 C6orf173 0.46 6.34 0.36 1e-9 Male-pattern baldness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09596239 chr2:130940036 SMPD4;FAM128B -0.61 -6.9 -0.39 3.89e-11 Gut microbiome composition (summer); CESC cis rs7714584 1.000 rs7716903 chr5:150258574 C/A cg22134413 chr5:150180641 NA 0.48 5.35 0.31 1.86e-7 Crohn's disease; CESC cis rs1451375 0.652 rs7803903 chr7:50625945 C/T cg14593290 chr7:50529359 DDC 0.45 5.45 0.32 1.15e-7 Malaria; CESC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg06456125 chr7:65229604 NA 0.39 5.05 0.3 8.06e-7 Aortic root size; CESC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg23161317 chr6:28129485 ZNF389 0.49 6.17 0.35 2.49e-9 Parkinson's disease; CESC cis rs10242455 0.702 rs6956305 chr7:99241310 A/G cg25640893 chr7:99214727 ZNF498 0.78 5.24 0.31 3.31e-7 Blood metabolite levels; CESC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg11941060 chr3:133502564 NA -0.47 -6.27 -0.36 1.48e-9 Iron status biomarkers; CESC cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg20503657 chr10:835505 NA 0.75 7.64 0.42 4.08e-13 Eosinophil percentage of granulocytes; CESC cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg18512352 chr11:47633146 NA -0.6 -9.28 -0.5 6.06e-18 Subjective well-being; CESC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs34779708 0.733 rs60616028 chr10:35543802 G/A cg03585969 chr10:35415529 CREM 0.52 5.66 0.33 3.89e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs4835473 0.932 rs7664248 chr4:144653707 C/T cg25736465 chr4:144833511 NA 0.38 5.75 0.33 2.41e-8 Immature fraction of reticulocytes; CESC cis rs9560113 0.580 rs9560115 chr13:112193619 G/A cg10483660 chr13:112241077 NA 0.4 6.57 0.37 2.59e-10 Menarche (age at onset); CESC cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg05340658 chr4:99064831 C4orf37 -0.77 -11.6 -0.58 1.98e-25 Colonoscopy-negative controls vs population controls; CESC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg13393036 chr8:95962371 TP53INP1 0.45 8.19 0.45 1.1e-14 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18758298 chr6:167040735 RPS6KA2 -0.52 -6.05 -0.35 4.92e-9 Gut microbiome composition (summer); CESC cis rs1152591 0.543 rs1152590 chr14:64681193 C/T cg23250157 chr14:64679961 SYNE2 0.4 5.78 0.33 2.06e-8 Atrial fibrillation; CESC cis rs710865 0.519 rs3748759 chr1:19487656 C/T cg13387374 chr1:19411106 UBR4 -0.51 -6.87 -0.39 4.68e-11 Brain structure; CESC cis rs6938 0.534 rs59945415 chr15:75228427 C/A cg09165964 chr15:75287851 SCAMP5 0.47 6.32 0.36 1.12e-9 Breast cancer; CESC cis rs72781680 1.000 rs74704838 chr2:24158270 C/A cg08917208 chr2:24149416 ATAD2B 0.94 8.66 0.47 4.66e-16 Lymphocyte counts; CESC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg08968635 chr6:28129556 ZNF389 0.41 5.28 0.31 2.7e-7 Depression; CESC cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.43 5.66 0.33 3.98e-8 Personality dimensions; CESC cis rs11229555 1.000 rs12799215 chr11:58405674 C/T cg15696309 chr11:58395628 NA -0.44 -5.69 -0.33 3.36e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs6546550 0.713 rs6718517 chr2:70018462 T/C cg02498382 chr2:70120550 SNRNP27 -0.34 -5.75 -0.33 2.43e-8 Prevalent atrial fibrillation; CESC cis rs644799 1.000 rs525404 chr11:95566520 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 13.66 0.64 1.57e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2952156 0.684 rs931992 chr17:37821435 G/T cg20243544 chr17:37824526 PNMT 0.67 9.11 0.49 2.03e-17 Asthma; CESC cis rs870825 0.616 rs7683615 chr4:185618373 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC trans rs4689592 0.503 rs4689064 chr4:7055603 A/G cg07817883 chr1:32538562 TMEM39B 0.6 6.16 0.35 2.63e-9 Monocyte percentage of white cells; CESC cis rs7267979 0.844 rs6107027 chr20:25288632 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 14.66 0.67 4.74e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs2455799 0.634 rs1584326 chr3:15903951 G/A cg16303742 chr3:15540471 COLQ -0.38 -5.93 -0.34 9.55e-9 Mean platelet volume; CESC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg17971929 chr21:40555470 PSMG1 -0.87 -12.83 -0.62 1.2e-29 Cognitive function; CESC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg19717773 chr7:2847554 GNA12 -0.56 -8.04 -0.44 2.94e-14 Height; CESC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg14664628 chr15:75095509 CSK -0.58 -8.0 -0.44 3.88e-14 Breast cancer; CESC cis rs60154123 0.772 rs701942 chr1:210429392 C/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.5 5.32 0.31 2.26e-7 Coronary artery disease; CESC cis rs9287719 0.901 rs6432109 chr2:10736821 A/G cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs72772090 0.539 rs11741100 chr5:96113245 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -5.04 -0.3 8.6e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618501 0.521 rs952594 chr3:49908023 G/A cg24110177 chr3:50126178 RBM5 -0.54 -7.2 -0.4 6.37e-12 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07155158 chr17:79164542 AZI1 -0.54 -6.61 -0.38 2.08e-10 Gut microbiome composition (summer); CESC cis rs7662987 1.000 rs4699699 chr4:99997179 C/G cg13256891 chr4:100009986 ADH5 -0.83 -6.1 -0.35 3.82e-9 Smoking initiation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09616526 chr16:21415657 NPIPL3 0.41 6.04 0.35 5.07e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs208520 0.690 rs207081 chr6:66773742 A/G cg07460842 chr6:66804631 NA -0.99 -13.2 -0.63 6.27e-31 Exhaled nitric oxide output; CESC cis rs2439831 0.850 rs7169322 chr15:44131014 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.43 0.42 1.45e-12 Lung cancer in ever smokers; CESC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.43 -5.72 -0.33 2.9e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9486715 0.929 rs2025044 chr6:97067028 A/G cg18709589 chr6:96969512 KIAA0776 -0.46 -6.31 -0.36 1.19e-9 Headache; CESC cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg05347473 chr6:146136440 FBXO30 -0.52 -6.32 -0.36 1.1e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg03467027 chr4:99064603 C4orf37 0.47 6.0 0.35 6.55e-9 Colonoscopy-negative controls vs population controls; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg21156815 chr8:22526736 BIN3 0.45 6.11 0.35 3.55e-9 Breast cancer;Type 2 diabetes; CESC cis rs1707322 1.000 rs785506 chr1:46540652 C/T cg05343316 chr1:45956843 TESK2 -0.44 -5.26 -0.31 2.94e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg21951975 chr1:209979733 IRF6 0.61 7.76 0.43 1.91e-13 Cleft lip with or without cleft palate; CESC cis rs9486719 0.552 rs9399923 chr6:96850379 G/A cg06623918 chr6:96969491 KIAA0776 0.74 8.38 0.46 3.17e-15 Migraine;Coronary artery disease; CESC cis rs1451375 0.572 rs11575463 chr7:50547173 A/G cg14593290 chr7:50529359 DDC -0.56 -6.93 -0.39 3.18e-11 Malaria; CESC cis rs6500395 1.000 rs2080508 chr16:48690665 G/C cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs116095464 0.558 rs62344345 chr5:257420 C/T cg22857025 chr5:266934 NA -1.29 -18.21 -0.75 1.29e-48 Breast cancer; CESC cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg22834771 chr12:69754056 YEATS4 -0.48 -6.38 -0.37 7.7e-10 Blood protein levels; CESC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg14703610 chr5:56206110 C5orf35 0.52 6.88 0.39 4.3e-11 Coronary artery disease; CESC cis rs7818688 0.697 rs76631135 chr8:95980988 G/T cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs34286592 1.000 rs34286592 chr16:29820480 C/T cg27338089 chr16:29820515 MAZ 0.56 5.56 0.32 6.51e-8 Multiple sclerosis; CESC cis rs1707322 1.000 rs11211222 chr1:46367757 T/C cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1994135 0.630 rs11052757 chr12:33719879 A/G cg26384229 chr12:38710491 ALG10B 0.58 7.82 0.43 1.26e-13 Resting heart rate; CESC cis rs7826238 0.564 rs2921053 chr8:8319963 G/C cg06636001 chr8:8085503 FLJ10661 0.56 7.19 0.4 6.56e-12 Systolic blood pressure; CESC cis rs7674212 0.537 rs2623060 chr4:104047504 G/A cg16532752 chr4:104119610 CENPE -0.44 -6.02 -0.35 5.8e-9 Type 2 diabetes; CESC cis rs17376456 0.825 rs66564678 chr5:93165894 C/T cg21475434 chr5:93447410 FAM172A 0.82 7.34 0.41 2.67e-12 Diabetic retinopathy; CESC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg25036284 chr2:26402008 FAM59B -0.83 -9.55 -0.51 8.86e-19 Gut microbiome composition (summer); CESC cis rs1055129 0.681 rs7221792 chr17:73834690 T/G cg08125733 chr17:73851984 WBP2 0.55 7.57 0.42 6.36e-13 White matter hyperintensity burden; CESC cis rs78889164 0.956 rs6510375 chr19:33850871 A/G cg02272751 chr19:33882848 PEPD -0.5 -6.44 -0.37 5.56e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg17366294 chr4:99064904 C4orf37 -0.61 -8.85 -0.48 1.23e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg18240062 chr17:79603768 NPLOC4 0.72 10.27 0.53 4.71e-21 Eye color traits; CESC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7508 0.694 rs12541181 chr8:17923499 C/G cg18067069 chr8:17937731 ASAH1 -0.4 -5.42 -0.32 1.36e-7 Atrial fibrillation; CESC cis rs9926296 0.609 rs4785709 chr16:89796665 G/A cg04287289 chr16:89883240 FANCA -0.62 -8.06 -0.44 2.59e-14 Vitiligo; CESC cis rs9902453 0.904 rs9897794 chr17:28296327 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.59 0.47 7.72e-16 Coffee consumption (cups per day); CESC cis rs4727963 0.792 rs11769400 chr7:122727366 A/G cg03640110 chr7:122635026 TAS2R16 -0.41 -6.31 -0.36 1.2e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs2455799 0.613 rs4685258 chr3:15792315 G/A cg09340198 chr3:15902540 ANKRD28 -0.33 -5.16 -0.3 4.94e-7 Mean platelet volume; CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg22907277 chr7:1156413 C7orf50 0.4 5.97 0.34 7.42e-9 Longevity;Endometriosis; CESC cis rs34375054 0.624 rs12832525 chr12:125680366 T/C cg25124228 chr12:125621409 AACS -0.47 -5.32 -0.31 2.19e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs7674212 0.570 rs6813563 chr4:104099110 G/A cg16532752 chr4:104119610 CENPE -0.44 -6.01 -0.35 6.03e-9 Type 2 diabetes; CESC cis rs962856 0.575 rs673005 chr2:67654381 C/G cg09028215 chr2:67624308 ETAA1 -0.43 -5.3 -0.31 2.49e-7 Pancreatic cancer; CESC cis rs10242455 0.867 rs2687087 chr7:99294472 G/A cg07715041 chr7:99302981 CYP3A7 -0.44 -5.48 -0.32 9.68e-8 Blood metabolite levels; CESC cis rs453301 0.682 rs2929308 chr8:9084121 T/A cg15556689 chr8:8085844 FLJ10661 -0.52 -6.76 -0.38 8.51e-11 Joint mobility (Beighton score); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01524091 chr6:44281032 AARS2 0.59 7.21 0.4 6e-12 Gut microbiome composition (summer); CESC cis rs7259376 0.936 rs4932760 chr19:22540455 T/G cg02657401 chr19:22469223 NA -0.25 -5.09 -0.3 6.84e-7 Menopause (age at onset); CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.64 -8.92 -0.48 7.89e-17 Prudent dietary pattern; CESC cis rs10088262 0.540 rs6988602 chr8:124788502 C/T cg02993010 chr8:124780839 FAM91A1 0.57 6.68 0.38 1.38e-10 Pancreatic cancer; CESC cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg27347728 chr4:17578864 LAP3 -0.5 -5.88 -0.34 1.26e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs61931739 1.000 rs11502817 chr12:34010676 T/C cg26384229 chr12:38710491 ALG10B -0.45 -6.19 -0.36 2.24e-9 Morning vs. evening chronotype; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25974586 chr20:32031867 SNTA1 0.55 7.41 0.41 1.72e-12 Gut microbiota (bacterial taxa); CESC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.41e-28 Prudent dietary pattern; CESC cis rs6496667 0.779 rs7175476 chr15:91027184 G/C cg13834112 chr15:90361639 NA 0.39 5.05 0.3 8.11e-7 Rheumatoid arthritis; CESC cis rs1976403 0.659 rs10799700 chr1:21820968 G/C cg04349561 chr1:21808255 NBPF3 -0.4 -5.84 -0.34 1.49e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg02297831 chr4:17616191 MED28 0.61 7.82 0.43 1.26e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1153858 1.000 rs4395020 chr15:45652889 A/C cg14582100 chr15:45693742 SPATA5L1 0.43 6.07 0.35 4.35e-9 Homoarginine levels; CESC cis rs60515486 0.702 rs11039194 chr11:47374928 C/G cg25783544 chr11:47291846 MADD 0.55 5.1 0.3 6.34e-7 Lymphocyte counts; CESC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.7 0.33 3.27e-8 Bipolar disorder; CESC cis rs67460515 0.563 rs4521287 chr3:160812752 C/T cg03342759 chr3:160939853 NMD3 -0.5 -6.2 -0.36 2.15e-9 Parkinson's disease; CESC cis rs6540556 0.954 rs10489342 chr1:209935778 A/G cg23920097 chr1:209922102 NA -0.37 -5.59 -0.32 5.64e-8 Red blood cell count; CESC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg08736216 chr1:53307985 ZYG11A -0.4 -7.29 -0.41 3.55e-12 Monocyte count; CESC cis rs9672608 1.000 rs9672608 chr15:78797463 T/A cg24631222 chr15:78858424 CHRNA5 0.63 7.13 0.4 9.76e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs6964587 0.967 rs12538325 chr7:91757479 A/G cg17063962 chr7:91808500 NA 0.54 7.23 0.41 5.27e-12 Breast cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15421363 chr5:131826865 IRF1 -0.45 -6.48 -0.37 4.48e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg09509183 chr1:209979624 IRF6 0.56 5.86 0.34 1.4e-8 Cleft lip with or without cleft palate; CESC cis rs7084402 0.967 rs1649063 chr10:60309215 G/A cg07615347 chr10:60278583 BICC1 0.59 9.34 0.5 4.21e-18 Refractive error; CESC cis rs7923609 0.905 rs10740129 chr10:65250808 G/A cg01631684 chr10:65280961 REEP3 -0.43 -5.4 -0.31 1.49e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs798766 1.000 rs798724 chr4:1704643 C/T cg05874882 chr4:1763078 NA -0.58 -8.13 -0.45 1.7e-14 Bladder cancer;Urinary bladder cancer; CESC cis rs7772486 0.869 rs2777473 chr6:146301494 G/A cg05347473 chr6:146136440 FBXO30 0.5 6.72 0.38 1.08e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg23758822 chr17:41437982 NA 1.03 15.1 0.68 1.35e-37 Menopause (age at onset); CESC cis rs2439831 0.867 rs2470134 chr15:43849886 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.83 -8.53 -0.46 1.12e-15 Lung cancer in ever smokers; CESC cis rs7520050 0.966 rs34102169 chr1:46424864 G/T cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.54e-8 Red blood cell count;Reticulocyte count; CESC trans rs79976124 0.837 rs10455591 chr6:66650584 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 8.79 0.48 1.94e-16 Type 2 diabetes; CESC cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.64 9.36 0.5 3.63e-18 Total body bone mineral density; CESC cis rs6831352 0.918 rs28987088 chr4:100059139 T/C cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs72829446 0.530 rs8075009 chr17:7374508 A/T cg02795151 chr17:7402630 POLR2A 0.58 5.99 0.35 6.89e-9 Androgen levels; CESC cis rs2279817 0.863 rs2354291 chr1:18027554 G/T cg21791023 chr1:18019539 ARHGEF10L -0.56 -8.38 -0.46 3.16e-15 Neuroticism; CESC cis rs3820928 0.874 rs4675134 chr2:227843489 C/T cg05526886 chr2:227700861 RHBDD1 -0.42 -5.26 -0.31 3.05e-7 Pulmonary function; CESC cis rs4899260 0.826 rs1274955 chr14:69289312 A/C cg03189333 chr14:69283534 NA 0.45 5.05 0.3 8.35e-7 Celiac disease; CESC cis rs9303401 0.659 rs62083368 chr17:56878062 G/A cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.68 0.61 4.11e-29 Cognitive test performance; CESC cis rs2050392 0.590 rs694346 chr10:30711929 C/T cg18806716 chr10:30721971 MAP3K8 -0.63 -9.24 -0.49 8.53e-18 Inflammatory bowel disease; CESC cis rs754466 0.580 rs1866437 chr10:79526766 A/G cg17075019 chr10:79541650 NA -0.83 -12.94 -0.62 5.15e-30 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg23758822 chr17:41437982 NA 1.05 16.17 0.7 2.15e-41 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05707704 chr2:73144283 EMX1 0.54 6.08 0.35 4.15e-9 Gut microbiome composition (summer); CESC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg12963246 chr6:28129442 ZNF389 0.41 5.56 0.32 6.7e-8 Parkinson's disease; CESC cis rs4253772 0.530 rs9615990 chr22:46804154 G/A cg09491104 chr22:46646882 C22orf40 -0.5 -5.55 -0.32 7.09e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6912958 0.935 rs2179844 chr6:88165773 C/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.58 -8.0 -0.44 3.87e-14 Monocyte percentage of white cells; CESC cis rs9747201 0.963 rs11077982 chr17:80147377 G/C cg09264619 chr17:80180166 NA -0.42 -5.05 -0.3 8.04e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2979489 0.786 rs62508366 chr8:30369499 G/A cg26383811 chr8:30366931 RBPMS -0.81 -9.99 -0.52 3.71e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs8014204 1.000 rs4553560 chr14:75334199 T/C cg11812906 chr14:75593930 NEK9 -0.41 -5.1 -0.3 6.63e-7 Caffeine consumption; CESC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg22823121 chr1:150693482 HORMAD1 0.4 5.59 0.32 5.53e-8 Melanoma; CESC cis rs3820068 0.581 rs3940061 chr1:15941276 C/T cg16988262 chr1:15930761 NA 0.34 5.52 0.32 7.98e-8 Systolic blood pressure; CESC cis rs7264396 0.561 rs6060750 chr20:34596371 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -8.78 -0.47 2.12e-16 Total cholesterol levels; CESC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.05 10.88 0.56 4.76e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11098499 0.863 rs2170276 chr4:120485824 A/C cg25214090 chr10:38739885 LOC399744 0.66 9.03 0.49 3.57e-17 Corneal astigmatism; CESC cis rs2880765 0.835 rs1872074 chr15:86033184 T/G cg10818794 chr15:86012489 AKAP13 -0.35 -5.39 -0.31 1.6e-7 Coronary artery disease; CESC cis rs611744 0.870 rs613261 chr8:109165949 A/G cg21045802 chr8:109455806 TTC35 0.45 5.49 0.32 9.39e-8 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24641125 chr21:40721130 HMGN1 -0.63 -7.12 -0.4 1.04e-11 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs4660332 chr1:46461418 T/A cg06784218 chr1:46089804 CCDC17 0.36 6.01 0.35 5.95e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.14e-12 Tonsillectomy; CESC cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg17376030 chr22:41985996 PMM1 -0.74 -8.27 -0.45 6.75e-15 Vitiligo; CESC cis rs6582630 0.555 rs10880624 chr12:38526316 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.43 0.37 6.06e-10 Drug-induced liver injury (flucloxacillin); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05522046 chr3:52931664 TMEM110 -0.47 -6.85 -0.39 5.26e-11 Gambling; CESC cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.39e-30 Prudent dietary pattern; CESC cis rs5753618 0.583 rs9606839 chr22:31802710 A/C cg02404636 chr22:31891804 SFI1 0.41 5.6 0.33 5.36e-8 Colorectal cancer; CESC cis rs7412746 0.611 rs2228099 chr1:150808889 C/G cg22823121 chr1:150693482 HORMAD1 0.41 6.08 0.35 4.28e-9 Melanoma; CESC cis rs6424115 0.733 rs2502996 chr1:24199041 T/C cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC cis rs11638352 0.661 rs2706491 chr15:44423829 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -5.29 -0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs757110 0.866 rs5215 chr11:17408630 C/T cg15432903 chr11:17409602 KCNJ11 0.7 9.78 0.52 1.68e-19 Type 2 diabetes; CESC trans rs7666738 0.830 rs4292341 chr4:98959724 C/T cg24789503 chr3:195384528 SDHAP2 0.42 6.04 0.35 5.05e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2832191 0.791 rs4817270 chr21:30480368 G/A cg08807101 chr21:30365312 RNF160 -0.76 -10.82 -0.55 7.78e-23 Dental caries; CESC cis rs7246657 0.882 rs6508716 chr19:37819010 T/C cg23950597 chr19:37808831 NA -0.55 -6.04 -0.35 5.24e-9 Coronary artery calcification; CESC cis rs1707322 0.721 rs7520123 chr1:46235219 C/G cg06784218 chr1:46089804 CCDC17 0.4 7.28 0.41 3.81e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2108622 0.727 rs12610967 chr19:15977929 C/A cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs12579753 0.917 rs10778833 chr12:82197983 G/T cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs9911578 1.000 rs12952832 chr17:56906254 T/C cg12560992 chr17:57184187 TRIM37 0.94 15.75 0.7 6.57e-40 Intelligence (multi-trait analysis); CESC cis rs752010 0.714 rs2182606 chr1:42082375 T/C cg06885757 chr1:42089581 HIVEP3 0.51 8.96 0.48 5.79e-17 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04194001 chr2:43823104 THADA 0.59 7.0 0.4 2.14e-11 Gut microbiome composition (summer); CESC cis rs8017423 0.605 rs2149652 chr14:90813429 T/C cg14092571 chr14:90743983 NA 0.52 8.04 0.44 2.92e-14 Mortality in heart failure; CESC cis rs2481665 0.904 rs2481677 chr1:62632571 G/A cg18591186 chr1:62594603 INADL -0.47 -5.55 -0.32 7.09e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1401999 0.966 rs4148585 chr3:183670642 A/G cg01324343 chr3:183735012 ABCC5 0.64 13.59 0.64 2.93e-32 Anterior chamber depth; CESC cis rs4973397 0.686 rs10933370 chr2:232289960 C/A cg09339159 chr2:232260559 B3GNT7 0.5 5.41 0.32 1.38e-7 Anti-saccade response; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14971544 chr1:54955149 NA -0.51 -6.31 -0.36 1.17e-9 Asthma; CESC cis rs1210638 0.575 rs11703200 chr22:18959169 G/A cg23029801 chr22:18958135 DGCR5 0.47 5.12 0.3 5.79e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs57709857 0.957 rs1488936 chr8:38213739 A/T cg01506891 chr8:38243824 LETM2 0.48 5.07 0.3 7.53e-7 Autism spectrum disorder or schizophrenia; CESC cis rs17253792 0.822 rs77599953 chr14:56058905 C/T cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg24110177 chr3:50126178 RBM5 -0.54 -7.55 -0.42 7.06e-13 Intelligence (multi-trait analysis); CESC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg17143192 chr8:8559678 CLDN23 0.78 9.13 0.49 1.82e-17 Obesity-related traits; CESC cis rs3767633 0.528 rs6671373 chr1:161890796 C/G cg27519958 chr1:161735129 ATF6 -0.48 -6.02 -0.35 5.83e-9 IgG glycosylation; CESC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg22862634 chr11:62369728 EML3;MTA2 0.48 6.39 0.37 7.6e-10 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs2370759 1.000 rs76467481 chr10:32610740 T/G cg18270830 chr10:32634957 EPC1 0.67 6.41 0.37 6.52e-10 Sexual dysfunction (female); CESC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Parkinson's disease; CESC cis rs3815700 1.000 rs8109885 chr19:33095557 A/G cg24916020 chr19:33096688 ANKRD27 0.59 5.72 0.33 2.85e-8 Eosinophilic esophagitis; CESC cis rs3747547 0.892 rs56408868 chr9:38003124 G/T cg13774184 chr9:37916125 SHB -0.73 -6.23 -0.36 1.82e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs709400 0.859 rs7154948 chr14:104022944 C/T cg12935359 chr14:103987150 CKB -0.48 -6.37 -0.36 8.14e-10 Body mass index; CESC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg27266027 chr21:40555129 PSMG1 0.44 5.24 0.31 3.26e-7 Cognitive function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23610820 chr19:43774921 PSG9 -0.43 -6.35 -0.36 9.06e-10 Gut microbiota (bacterial taxa); CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg25934064 chr3:52569026 NT5DC2 0.25 5.19 0.3 4.14e-7 Electroencephalogram traits; CESC cis rs7635838 0.617 rs346075 chr3:11294027 T/G cg00170343 chr3:11313890 ATG7 0.58 8.54 0.46 1.1e-15 HDL cholesterol; CESC cis rs7129220 0.528 rs11042633 chr11:10141558 G/A cg01453529 chr11:10209919 SBF2 -0.4 -5.07 -0.3 7.4e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs10979 0.931 rs9484771 chr6:143896897 T/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.07e-17 Hypospadias; CESC cis rs3087591 0.960 rs12942397 chr17:29462498 C/A cg24425628 chr17:29625626 OMG;NF1 0.42 5.17 0.3 4.57e-7 Hip circumference; CESC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg23131131 chr22:24373011 LOC391322 -0.71 -10.07 -0.53 2.01e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1499972 0.680 rs62264772 chr3:117647281 G/A cg07612923 chr3:117604196 NA 0.69 6.15 0.35 2.83e-9 Schizophrenia; CESC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg23131131 chr22:24373011 LOC391322 0.63 8.65 0.47 5.05e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg12463550 chr7:65579703 CRCP 0.46 5.84 0.34 1.51e-8 Aortic root size; CESC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg00684032 chr4:1343700 KIAA1530 0.54 8.25 0.45 7.48e-15 Obesity-related traits; CESC cis rs9894429 0.816 rs7406040 chr17:79597583 A/C cg21984481 chr17:79567631 NPLOC4 -0.56 -8.99 -0.48 4.98e-17 Eye color traits; CESC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg14893161 chr1:205819251 PM20D1 -0.5 -6.99 -0.39 2.22e-11 Menarche (age at onset); CESC cis rs7605827 1.000 rs7605827 chr2:15598740 A/T cg19274914 chr2:15703543 NA 0.32 5.67 0.33 3.71e-8 Educational attainment (years of education); CESC cis rs77741769 0.534 rs58918988 chr12:121332953 G/A cg02419362 chr12:121203948 SPPL3 0.35 5.6 0.33 5.33e-8 Mean corpuscular volume; CESC cis rs1538970 0.962 rs3219463 chr1:45806432 C/T cg05343316 chr1:45956843 TESK2 0.84 10.56 0.54 5.37e-22 Platelet count; CESC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg11764359 chr7:65958608 NA 0.79 10.15 0.53 1.14e-20 Aortic root size; CESC cis rs7577696 0.606 rs212747 chr2:32414704 A/G cg02381751 chr2:32503542 YIPF4 0.45 5.33 0.31 2.12e-7 Inflammatory biomarkers; CESC trans rs853679 0.546 rs13214023 chr6:28332141 A/G cg06606381 chr12:133084897 FBRSL1 0.89 8.23 0.45 8.28e-15 Depression; CESC cis rs10883723 0.810 rs6584507 chr10:104254623 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs1400745 0.729 rs1741196 chr14:35347020 G/A cg16230307 chr14:35515116 FAM177A1 0.44 5.25 0.31 3.18e-7 Monocyte count; CESC trans rs3816587 0.839 rs6840622 chr4:25423123 C/T cg01822600 chr1:245751692 KIF26B 0.41 6.04 0.35 5.19e-9 Rheumatoid arthritis; CESC cis rs1256061 0.603 rs1256036 chr14:64743332 C/T cg23250157 chr14:64679961 SYNE2 0.53 7.63 0.42 4.14e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2404602 0.647 rs11852395 chr15:77087785 T/C cg23625390 chr15:77176239 SCAPER -0.4 -5.24 -0.31 3.32e-7 Blood metabolite levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15133824 chr2:97523823 ANKRD39 -0.42 -6.32 -0.36 1.09e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11828289 0.660 rs79067807 chr11:23228262 T/C cg20040320 chr11:23191996 NA -0.7 -6.07 -0.35 4.45e-9 Cancer; CESC trans rs61931739 0.500 rs6488222 chr12:34526289 G/A cg13010199 chr12:38710504 ALG10B 0.5 6.42 0.37 6.3e-10 Morning vs. evening chronotype; CESC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg18876405 chr7:65276391 NA 0.53 7.28 0.41 3.9e-12 Aortic root size; CESC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg08027265 chr7:2291960 NA -0.38 -5.86 -0.34 1.39e-8 Schizophrenia; CESC cis rs7267979 1.000 rs910997 chr20:25267301 G/A cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7814319 1.000 rs2643338 chr8:97247469 A/G cg20787634 chr8:97240163 UQCRB -0.52 -6.66 -0.38 1.61e-10 Lung function (FVC); CESC cis rs2721195 0.719 rs4925812 chr8:145808035 C/T cg11211951 chr8:145729740 GPT 0.42 7.02 0.4 1.91e-11 Age at first birth; CESC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 10.91 0.56 3.89e-23 Personality dimensions; CESC cis rs7647973 0.580 rs4955432 chr3:49266772 C/T cg07636037 chr3:49044803 WDR6 0.81 13.43 0.64 1.05e-31 Menarche (age at onset); CESC cis rs9790314 0.846 rs12495310 chr3:160970956 T/A cg03342759 chr3:160939853 NMD3 -0.51 -7.39 -0.41 1.96e-12 Morning vs. evening chronotype; CESC cis rs6499255 0.951 rs9788837 chr16:69688413 A/G cg15192750 chr16:69999425 NA 0.5 5.77 0.33 2.19e-8 IgE levels; CESC cis rs2985684 1.000 rs2985696 chr14:50094913 C/A cg02151108 chr14:50098012 C14orf104 -0.44 -5.59 -0.32 5.6e-8 Carotid intima media thickness; CESC cis rs2486288 0.656 rs8040185 chr15:45552081 G/A cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg24531977 chr5:56204891 C5orf35 -0.89 -11.26 -0.57 2.62e-24 Initial pursuit acceleration; CESC cis rs2519796 0.531 rs2810534 chr9:136806225 A/G cg13751417 chr9:136814406 VAV2 -0.43 -5.74 -0.33 2.59e-8 Hematocrit;Hemoglobin concentration; CESC cis rs3096299 0.933 rs2965938 chr16:89491336 C/T cg08822215 chr16:89438651 ANKRD11 -0.36 -5.48 -0.32 1.01e-7 Multiple myeloma (IgH translocation); CESC cis rs12142240 0.698 rs67941619 chr1:46838219 A/G cg10495392 chr1:46806563 NSUN4 0.58 6.26 0.36 1.54e-9 Menopause (age at onset); CESC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg24881330 chr22:46731750 TRMU 0.79 6.34 0.36 1.01e-9 LDL cholesterol;Cholesterol, total; CESC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.45 5.26 0.31 2.94e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg05368731 chr17:41323189 NBR1 0.75 10.32 0.54 3.35e-21 Menopause (age at onset); CESC cis rs7666738 0.830 rs11729753 chr4:98803267 T/A cg05340658 chr4:99064831 C4orf37 0.75 11.11 0.56 8.68e-24 Colonoscopy-negative controls vs population controls; CESC cis rs68170813 0.523 rs7781947 chr7:106902219 A/G cg02696742 chr7:106810147 HBP1 -0.52 -5.09 -0.3 6.84e-7 Coronary artery disease; CESC cis rs7264396 1.000 rs224440 chr20:34159447 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -7.32 -0.41 2.92e-12 Total cholesterol levels; CESC cis rs1707322 0.752 rs61784793 chr1:46149285 G/A cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20307448 chr11:134132814 ACAD8 -0.6 -6.93 -0.39 3.14e-11 Gut microbiome composition (summer); CESC cis rs2952156 0.684 rs931992 chr17:37821435 G/T cg07936489 chr17:37558343 FBXL20 -0.64 -8.56 -0.47 9.02e-16 Asthma; CESC cis rs4906332 1.000 rs34479426 chr14:103881823 G/C cg09975044 chr14:104007538 NA 0.45 6.26 0.36 1.58e-9 Coronary artery disease; CESC cis rs1546924 0.570 rs197413 chr1:112308972 G/A cg23955903 chr1:112298873 DDX20;C1orf183 0.43 5.55 0.32 6.88e-8 Body mass index; CESC cis rs7071206 0.947 rs10824560 chr10:79416901 C/T cg07817648 chr10:79422355 NA -0.87 -11.2 -0.57 4.32e-24 Bone mineral density; CESC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg19468946 chr17:37922297 IKZF3 0.4 5.22 0.31 3.56e-7 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.68 9.28 0.5 6.06e-18 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13668930 chr13:21563168 LATS2 -0.59 -6.73 -0.38 1.03e-10 Gut microbiome composition (summer); CESC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg04414720 chr1:150670196 GOLPH3L 0.62 8.93 0.48 7.24e-17 Tonsillectomy; CESC cis rs12410462 0.681 rs76705164 chr1:227615570 G/A cg04117972 chr1:227635322 NA 0.78 7.15 0.4 8.36e-12 Major depressive disorder; CESC cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg02297831 chr4:17616191 MED28 0.62 7.86 0.43 9.58e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7923609 1.000 rs7070296 chr10:65070438 T/A cg01631684 chr10:65280961 REEP3 -0.43 -5.42 -0.32 1.33e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs9916302 0.706 rs439537 chr17:37734482 T/C cg07936489 chr17:37558343 FBXL20 -0.97 -10.88 -0.56 4.83e-23 Glomerular filtration rate (creatinine); CESC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg08888203 chr3:10149979 C3orf24 0.48 6.0 0.35 6.52e-9 Alzheimer's disease; CESC cis rs4835473 0.897 rs7695328 chr4:144624921 A/G cg25736465 chr4:144833511 NA 0.37 5.56 0.32 6.67e-8 Immature fraction of reticulocytes; CESC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg16325326 chr1:53192061 ZYG11B 0.82 13.68 0.64 1.33e-32 Monocyte count; CESC trans rs1908814 0.516 rs11996277 chr8:11800031 G/A cg15556689 chr8:8085844 FLJ10661 0.53 6.67 0.38 1.51e-10 Neuroticism; CESC cis rs11581903 0.568 rs34087138 chr1:53083567 G/A cg19751897 chr1:52520827 TXNDC12;BTF3L4 0.71 5.21 0.31 3.72e-7 Joint mobility (Beighton score); CESC cis rs1215050 0.755 rs6851840 chr4:98776366 A/G cg05340658 chr4:99064831 C4orf37 0.53 6.89 0.39 4.01e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9733 0.687 rs12410050 chr1:150857141 A/G cg13175981 chr1:150552382 MCL1 0.55 7.44 0.42 1.39e-12 Tonsillectomy; CESC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg19592336 chr6:28129416 ZNF389 0.53 6.46 0.37 5.06e-10 Parkinson's disease; CESC cis rs8062405 0.755 rs4788078 chr16:28559981 G/A cg07382826 chr16:28625726 SULT1A1 0.4 6.69 0.38 1.3e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6424115 0.965 rs2502986 chr1:24135292 G/T cg10978503 chr1:24200527 CNR2 0.28 5.66 0.33 3.88e-8 Immature fraction of reticulocytes; CESC cis rs7937682 0.889 rs559482 chr11:111497902 G/A cg22437258 chr11:111473054 SIK2 0.71 9.22 0.49 9.53e-18 Primary sclerosing cholangitis; CESC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg02725872 chr8:58115012 NA -0.42 -5.64 -0.33 4.38e-8 Developmental language disorder (linguistic errors); CESC trans rs11039798 1.000 rs7104642 chr11:48588534 C/T cg15704280 chr7:45808275 SEPT13 0.7 6.57 0.37 2.68e-10 Axial length; CESC cis rs524023 0.957 rs893006 chr11:64365796 C/A cg07220939 chr11:64358617 SLC22A12 -0.34 -5.12 -0.3 5.79e-7 Urate levels in obese individuals; CESC cis rs14403 1.000 rs74777638 chr1:243661742 T/C cg21452805 chr1:244014465 NA 0.49 5.62 0.33 4.93e-8 Schizophrenia; CESC cis rs2933343 0.672 rs1872545 chr3:128645039 G/C cg24203234 chr3:128598194 ACAD9 0.44 5.94 0.34 9.15e-9 IgG glycosylation; CESC cis rs5769765 1.000 rs5769765 chr22:50271176 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC trans rs11098499 0.754 rs878372 chr4:120238780 A/C cg25214090 chr10:38739885 LOC399744 0.61 8.51 0.46 1.33e-15 Corneal astigmatism; CESC cis rs2635047 0.638 rs2668762 chr18:44667871 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.44 -5.51 -0.32 8.49e-8 Educational attainment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10949413 chr6:26158832 HIST1H2BD 0.51 6.06 0.35 4.68e-9 Gut microbiome composition (summer); CESC cis rs3749237 0.595 rs11130196 chr3:49490149 A/C cg02487422 chr3:49467188 NICN1 0.58 8.47 0.46 1.72e-15 Resting heart rate; CESC cis rs7408868 1.000 rs10407320 chr19:15275716 G/C cg14696996 chr19:15285081 NOTCH3 1.11 11.47 0.58 5.57e-25 Pulse pressure; CESC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg22903471 chr2:27725779 GCKR -0.55 -7.87 -0.44 9.28e-14 Total body bone mineral density; CESC cis rs8177179 1.000 rs8177179 chr3:133463457 G/A cg24879335 chr3:133465180 TF 0.44 8.37 0.46 3.38e-15 Iron status biomarkers (transferrin levels); CESC cis rs9611565 0.592 rs5996039 chr22:41981957 A/G cg03806693 chr22:41940476 POLR3H -0.87 -10.5 -0.54 8.63e-22 Vitiligo; CESC cis rs644799 0.932 rs480079 chr11:95643777 A/T cg03916912 chr11:95522834 CEP57;FAM76B -0.81 -12.52 -0.61 1.46e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9549260 0.564 rs9549279 chr13:41315582 C/G cg21288729 chr13:41239152 FOXO1 -0.6 -8.0 -0.44 3.93e-14 Red blood cell count; CESC cis rs28489187 0.706 rs233059 chr1:85798936 G/A cg16011679 chr1:85725395 C1orf52 0.48 5.68 0.33 3.58e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg11663144 chr21:46675770 NA 0.41 6.01 0.35 6.06e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4689388 0.791 rs1046317 chr4:6304242 T/C cg25554036 chr4:6271136 WFS1 0.52 7.79 0.43 1.47e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs12618769 0.625 rs4850880 chr2:99212417 C/T cg10123293 chr2:99228465 UNC50 0.4 5.19 0.3 4.2e-7 Bipolar disorder; CESC cis rs71403859 0.730 rs17356316 chr16:71746921 C/T cg08717414 chr16:71523259 ZNF19 -0.7 -5.57 -0.32 6.22e-8 Post bronchodilator FEV1; CESC cis rs1801251 1.000 rs13003675 chr2:233584109 C/T cg08000102 chr2:233561755 GIGYF2 0.7 9.66 0.51 4.15e-19 Coronary artery disease; CESC cis rs10979 0.597 rs9496691 chr6:143910970 T/C cg25407410 chr6:143891975 LOC285740 -0.48 -6.41 -0.37 6.52e-10 Hypospadias; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08527179 chr2:85132050 TMSB10 -0.62 -7.66 -0.43 3.55e-13 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs12042052 0.793 rs7534632 chr1:232910796 G/A cg06935979 chr1:232941706 KIAA1383 0.6 5.2 0.3 3.92e-7 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs2204008 0.683 rs11522927 chr12:38137537 C/T cg13010199 chr12:38710504 ALG10B 0.55 6.73 0.38 1.07e-10 Bladder cancer; CESC cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg24110177 chr3:50126178 RBM5 0.52 7.15 0.4 8.33e-12 Intelligence (multi-trait analysis); CESC cis rs4746818 0.793 rs2805914 chr10:70859291 A/G cg11621586 chr10:70884670 VPS26A 0.81 7.86 0.43 9.48e-14 Left atrial antero-posterior diameter; CESC cis rs77861329 1.000 rs72964044 chr3:52092670 G/C cg08692210 chr3:52188851 WDR51A 0.8 7.04 0.4 1.61e-11 Macrophage inflammatory protein 1b levels; CESC cis rs9847710 0.733 rs2581790 chr3:53101780 A/G cg18337363 chr3:52569053 NT5DC2 -0.31 -5.18 -0.3 4.32e-7 Ulcerative colitis; CESC trans rs61931739 0.534 rs1912773 chr12:34097401 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.25 0.45 7.65e-15 Morning vs. evening chronotype; CESC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg14558114 chr2:88469736 THNSL2 -0.49 -7.16 -0.4 7.82e-12 Response to metformin (IC50); CESC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg17178900 chr1:205818956 PM20D1 0.39 5.23 0.31 3.42e-7 Parkinson's disease; CESC cis rs722599 0.683 rs2302834 chr14:75279395 T/A cg11812906 chr14:75593930 NEK9 0.45 5.47 0.32 1.02e-7 IgG glycosylation; CESC trans rs1557351 0.569 rs8093490 chr18:54719691 A/G cg11433624 chr6:7146702 RREB1 0.37 6.14 0.35 3.05e-9 Multiple sclerosis (age of onset); CESC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg08061076 chr7:1943177 MAD1L1 -0.38 -5.05 -0.3 8.05e-7 Bipolar disorder and schizophrenia; CESC cis rs897080 0.515 rs1145519 chr2:44708709 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.57 0.32 6.38e-8 Height; CESC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg11890956 chr21:40555474 PSMG1 -0.64 -8.05 -0.44 2.88e-14 Menarche (age at onset); CESC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg00277769 chr7:97922759 BAIAP2L1 0.33 5.5 0.32 8.83e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg04450456 chr4:17643702 FAM184B 0.38 5.42 0.32 1.34e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2404602 0.552 rs11634428 chr15:77084582 T/C cg06336613 chr15:77223807 RCN2 0.42 5.13 0.3 5.69e-7 Blood metabolite levels; CESC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.97 0.34 7.51e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4555082 0.834 rs2735825 chr14:105710900 G/A cg27165867 chr14:105738592 BRF1 -0.52 -5.47 -0.32 1.06e-7 Mean platelet volume;Platelet distribution width; CESC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.89e-7 Gut microbiome composition (summer); CESC cis rs3818285 0.515 rs4918471 chr10:111660500 C/A cg00817464 chr10:111662876 XPNPEP1 -0.55 -7.59 -0.42 5.37e-13 Superior crus of antihelix expression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26943399 chr4:76649977 USO1 0.57 7.1 0.4 1.12e-11 Gut microbiome composition (summer); CESC cis rs7071206 1.000 rs7071206 chr10:79401316 C/T cg00983440 chr10:79422392 NA 0.61 7.71 0.43 2.6e-13 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06772644 chr1:40997203 ZNF684 0.6 6.52 0.37 3.54e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -7.32 -0.41 2.98e-12 Alzheimer's disease; CESC cis rs7937682 0.889 rs558736 chr11:111500760 C/G cg22437258 chr11:111473054 SIK2 0.69 9.08 0.49 2.56e-17 Primary sclerosing cholangitis; CESC cis rs5769765 1.000 rs5770728 chr22:50259984 G/A cg26441486 chr22:50317300 CRELD2 -0.4 -5.59 -0.32 5.61e-8 Schizophrenia; CESC cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg16339924 chr4:17578868 LAP3 0.61 7.62 0.42 4.4e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2034088 0.833 rs11247554 chr17:407465 C/A cg06217071 chr17:408420 NA 0.5 9.66 0.51 4.2e-19 Hip circumference adjusted for BMI; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg08799632 chr2:129026331 HS6ST1 0.49 6.91 0.39 3.61e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6061231 0.724 rs1570027 chr20:60968596 A/G cg24112000 chr20:60950667 NA -0.6 -7.28 -0.41 3.89e-12 Colorectal cancer; CESC cis rs7084402 0.934 rs1593673 chr10:60294170 C/T cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.35e-18 Refractive error; CESC cis rs9911578 1.000 rs368186 chr17:56736659 A/G cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC trans rs17514846 0.565 rs2521498 chr15:91442152 A/T cg02854288 chr3:61236911 FHIT 0.42 6.0 0.35 6.43e-9 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05792856 chr11:34379731 ABTB2 -0.47 -6.46 -0.37 4.94e-10 Fibrinogen levels; CESC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg19077165 chr18:44547161 KATNAL2 0.61 9.25 0.49 7.89e-18 Personality dimensions; CESC trans rs7672847 0.547 rs76005534 chr4:170490455 T/A cg19308436 chr1:237949471 RYR2 0.61 6.42 0.37 6.22e-10 Subjective well-being; CESC cis rs10911232 0.507 rs3934579 chr1:183027432 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.49 0.64 6.27e-32 Hypertriglyceridemia; CESC cis rs763014 0.865 rs8675 chr16:633843 A/G cg09263875 chr16:632152 PIGQ 0.66 11.04 0.56 1.45e-23 Height; CESC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs11252926 0.550 rs10795122 chr10:466830 C/T cg03684893 chr10:554711 DIP2C -0.41 -6.08 -0.35 4.16e-9 Psychosis in Alzheimer's disease; CESC cis rs4144743 0.877 rs7218773 chr17:45324211 C/T cg18085866 chr17:45331354 ITGB3 -0.66 -7.64 -0.43 3.87e-13 Body mass index; CESC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg21782813 chr7:2030301 MAD1L1 0.44 6.15 0.35 2.79e-9 Bipolar disorder and schizophrenia; CESC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg05132306 chr1:1846340 CALML6 -0.3 -6.3 -0.36 1.24e-9 Body mass index; CESC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg00339695 chr16:24857497 SLC5A11 0.5 6.54 0.37 3.11e-10 Intelligence (multi-trait analysis); CESC cis rs9911578 1.000 rs4636974 chr17:56965373 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.28 0.31 2.71e-7 Intelligence (multi-trait analysis); CESC cis rs2901656 0.583 rs6702667 chr1:172400484 A/C cg03748243 chr1:172413542 C1orf105;PIGC 0.47 6.68 0.38 1.42e-10 Red cell distribution width;Platelet distribution width; CESC cis rs7178572 1.000 rs7178572 chr15:77747190 A/G cg22256960 chr15:77711686 NA -0.58 -7.96 -0.44 4.91e-14 Type 2 diabetes; CESC cis rs6430585 0.528 rs309167 chr2:136669264 C/T cg07169764 chr2:136633963 MCM6 1.1 14.81 0.67 1.43e-36 Corneal structure; CESC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg04414720 chr1:150670196 GOLPH3L 0.44 5.86 0.34 1.37e-8 Melanoma; CESC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg22920501 chr2:26401640 FAM59B 0.91 10.38 0.54 2.08e-21 Gut microbiome composition (summer); CESC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg17376030 chr22:41985996 PMM1 0.72 7.81 0.43 1.35e-13 Vitiligo; CESC cis rs4481887 1.000 rs10888351 chr1:248451608 G/A cg00666640 chr1:248458726 OR2T12 0.39 6.44 0.37 5.74e-10 Common traits (Other); CESC cis rs3820928 0.874 rs10439363 chr2:227815065 C/T cg05526886 chr2:227700861 RHBDD1 -0.46 -5.88 -0.34 1.25e-8 Pulmonary function; CESC cis rs10461617 0.535 rs7709874 chr5:56047451 C/T cg12311346 chr5:56204834 C5orf35 -0.5 -6.2 -0.36 2.21e-9 Type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26270411 chr20:43514327 YWHAB 0.44 6.18 0.35 2.41e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9300255 0.537 rs10772993 chr12:123644714 A/G cg00376283 chr12:123451042 ABCB9 0.57 6.44 0.37 5.55e-10 Neutrophil percentage of white cells; CESC cis rs17376456 0.877 rs12716457 chr5:93397627 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.03 0.3 9.15e-7 Diabetic retinopathy; CESC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.55 0.37 2.92e-10 Bipolar disorder; CESC trans rs10776614 0.799 rs1345109 chr10:49765211 A/C cg19218067 chr2:181235115 NA -0.49 -6.14 -0.35 2.98e-9 Self-employment; CESC trans rs7246760 0.867 rs34648216 chr19:9850690 T/A cg02900749 chr2:68251473 NA -0.84 -7.32 -0.41 2.99e-12 Pursuit maintenance gain; CESC trans rs561341 0.830 rs7218801 chr17:30217778 A/G cg20587970 chr11:113659929 NA 0.97 11.45 0.58 6.48e-25 Hip circumference adjusted for BMI; CESC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg08736216 chr1:53307985 ZYG11A 0.4 6.33 0.36 1.04e-9 Monocyte count; CESC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.69 -0.33 3.35e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs3096299 0.781 rs2170839 chr16:89409452 C/G cg00750074 chr16:89608354 SPG7 -0.42 -5.72 -0.33 2.8e-8 Multiple myeloma (IgH translocation); CESC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg22442454 chr1:209979470 IRF6 0.5 6.22 0.36 1.98e-9 Cleft lip with or without cleft palate; CESC cis rs17407555 0.738 rs73212870 chr4:10111798 C/G cg00071950 chr4:10020882 SLC2A9 -0.53 -5.41 -0.32 1.44e-7 Schizophrenia (age at onset); CESC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg17221315 chr6:27791827 HIST1H4J -0.57 -5.85 -0.34 1.41e-8 Depression; CESC cis rs896854 0.517 rs1011795 chr8:95951073 G/A cg23172400 chr8:95962367 TP53INP1 -0.41 -7.23 -0.41 5.14e-12 Type 2 diabetes; CESC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg23172400 chr8:95962367 TP53INP1 -0.46 -9.8 -0.52 1.51e-19 Type 2 diabetes; CESC cis rs1348850 0.918 rs4893966 chr2:178470138 A/G cg23306229 chr2:178417860 TTC30B 0.6 7.59 0.42 5.59e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9467711 0.606 rs13203358 chr6:26590578 A/T cg14345882 chr6:26364793 BTN3A2 0.55 5.71 0.33 3.02e-8 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08037327 chr7:150211061 GIMAP7 -0.54 -6.44 -0.37 5.53e-10 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg17724175 chr1:150552817 MCL1 0.44 7.24 0.41 4.8e-12 Tonsillectomy; CESC cis rs9291683 0.588 rs35099040 chr4:10018839 T/C cg02734326 chr4:10020555 SLC2A9 0.52 7.42 0.41 1.61e-12 Bone mineral density; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg21790971 chr4:54244117 FIP1L1 -0.46 -6.13 -0.35 3.25e-9 Height; CESC cis rs9291683 0.588 rs13113730 chr4:10017628 C/T cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.73e-37 Bone mineral density; CESC cis rs367943 0.712 rs9326886 chr5:112728458 A/C cg12552261 chr5:112820674 MCC 0.38 5.08 0.3 7.02e-7 Type 2 diabetes; CESC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg02018176 chr4:1364513 KIAA1530 0.4 5.71 0.33 3.05e-8 Longevity; CESC cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -7.71 -0.43 2.58e-13 Tonsillectomy; CESC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.84 0.34 1.55e-8 Tonsillectomy; CESC cis rs754466 0.580 rs12356063 chr10:79558131 G/C cg17075019 chr10:79541650 NA -0.87 -13.75 -0.65 7.54e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg12463550 chr7:65579703 CRCP 0.67 5.38 0.31 1.67e-7 Diabetic kidney disease; CESC cis rs4268898 0.722 rs7563958 chr2:24422381 C/A cg06627628 chr2:24431161 ITSN2 0.58 7.6 0.42 5.29e-13 Asthma; CESC cis rs2933343 0.700 rs6787833 chr3:128656184 A/G cg11901034 chr3:128598214 ACAD9 -0.36 -5.27 -0.31 2.84e-7 IgG glycosylation; CESC cis rs3806843 0.932 rs2563269 chr5:140136468 G/T cg26395211 chr5:140044315 WDR55 0.44 5.53 0.32 7.53e-8 Depressive symptoms (multi-trait analysis); CESC cis rs3820068 0.532 rs78917815 chr1:15920821 A/G cg16988262 chr1:15930761 NA 0.35 5.63 0.33 4.6e-8 Systolic blood pressure; CESC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg23161317 chr6:28129485 ZNF389 0.39 5.48 0.32 1.01e-7 Cardiac Troponin-T levels; CESC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg23531748 chr20:60969906 CABLES2 -0.42 -5.62 -0.33 4.9e-8 Colorectal cancer; CESC cis rs317689 0.788 rs317679 chr12:69693172 A/C cg14784868 chr12:69753453 YEATS4 0.49 5.18 0.3 4.3e-7 Response to diuretic therapy; CESC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.73 -0.33 2.66e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23830810 chr12:120967582 COQ5 0.4 6.16 0.35 2.64e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6460942 0.511 rs13245890 chr7:12543134 A/C cg06484146 chr7:12443880 VWDE -0.71 -7.37 -0.41 2.24e-12 Coronary artery disease; CESC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg20151795 chr6:28129481 ZNF389 0.4 5.09 0.3 6.94e-7 Parkinson's disease; CESC cis rs4835473 0.932 rs35655934 chr4:144655850 T/C cg25736465 chr4:144833511 NA -0.33 -5.22 -0.31 3.68e-7 Immature fraction of reticulocytes; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15097968 chr15:63449935 RPS27L 0.47 6.21 0.36 1.98e-9 Systemic lupus erythematosus; CESC cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg09060608 chr5:178986726 RUFY1 0.46 6.44 0.37 5.53e-10 Lung cancer; CESC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg04772025 chr11:68637568 NA 0.5 6.07 0.35 4.44e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8060686 0.623 rs74024145 chr16:68153382 G/C cg26727032 chr16:67993705 SLC12A4 -0.59 -8.09 -0.44 2.19e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs67311347 0.911 rs9849224 chr3:40392562 T/C cg01475735 chr3:40494733 NA -0.41 -5.33 -0.31 2.06e-7 Renal cell carcinoma; CESC cis rs709400 0.658 rs72708874 chr14:103899251 T/G cg12935359 chr14:103987150 CKB -0.55 -7.97 -0.44 4.6e-14 Body mass index; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G ch.20.38346083F chr20:38912669 NA 0.48 6.35 0.36 9.56e-10 Neuroticism; CESC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg26119090 chr2:26468346 HADHA;HADHB -1.06 -12.59 -0.61 8.63e-29 Gut microbiome composition (summer); CESC cis rs2295359 0.892 rs4655686 chr1:67638004 T/A cg17031739 chr1:67600172 NA 0.4 5.2 0.3 4.05e-7 Psoriasis; CESC cis rs950776 0.593 rs588765 chr15:78865425 T/C cg06917634 chr15:78832804 PSMA4 -0.61 -8.21 -0.45 1.01e-14 Sudden cardiac arrest; CESC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg01238044 chr22:24384105 GSTT1 -0.45 -5.73 -0.33 2.72e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs763014 0.898 rs62030902 chr16:638264 C/G cg09263875 chr16:632152 PIGQ 0.69 11.43 0.57 7.14e-25 Height; CESC cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.34 -5.14 -0.3 5.33e-7 Personality dimensions; CESC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg11663144 chr21:46675770 NA -0.61 -9.69 -0.51 3.44e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25043602 chr13:113489734 ATP11A -0.57 -6.08 -0.35 4.29e-9 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.41e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs5753618 0.555 rs9609302 chr22:31895987 A/C cg00478049 chr22:31556069 RNF185 -0.44 -5.12 -0.3 5.86e-7 Colorectal cancer; CESC cis rs7208859 0.623 rs78071511 chr17:29128154 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3749237 0.595 rs1464568 chr3:49458266 G/A cg06212747 chr3:49208901 KLHDC8B 0.48 6.58 0.37 2.44e-10 Resting heart rate; CESC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg26343298 chr8:95960752 TP53INP1 0.37 5.94 0.34 8.73e-9 Type 2 diabetes; CESC cis rs8077889 0.871 rs8065043 chr17:41900984 G/A cg26893861 chr17:41843967 DUSP3 0.77 10.14 0.53 1.23e-20 Triglycerides; CESC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.73 0.33 2.75e-8 Menopause (age at onset); CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg10819733 chr22:24237672 NA -0.4 -5.61 -0.33 5e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3733585 0.699 rs6834893 chr4:9959123 C/T cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9908102 0.740 rs7216413 chr17:12900471 T/G cg26162695 chr17:12921313 ELAC2 0.52 5.72 0.33 2.91e-8 Schizophrenia; CESC cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg25208724 chr1:156163844 SLC25A44 1.01 18.98 0.76 2.67e-51 Testicular germ cell tumor; CESC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg13902645 chr11:5959945 NA 0.69 9.37 0.5 3.3e-18 DNA methylation (variation); CESC cis rs2243480 1.000 rs1499614 chr7:65730798 A/T cg12463550 chr7:65579703 CRCP 0.75 5.94 0.34 8.79e-9 Diabetic kidney disease; CESC cis rs55883249 1.000 rs62119392 chr2:9714033 G/C cg23886495 chr2:9695866 ADAM17 0.58 5.48 0.32 1e-7 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21582582 chr3:182698605 DCUN1D1 -0.44 -6.0 -0.35 6.29e-9 Intelligence (multi-trait analysis); CESC cis rs3096299 0.702 rs2086825 chr16:89471542 C/T cg02187348 chr16:89574699 SPG7 0.47 5.88 0.34 1.21e-8 Multiple myeloma (IgH translocation); CESC cis rs9325144 0.560 rs7314632 chr12:38636979 C/T cg13010199 chr12:38710504 ALG10B -0.43 -5.88 -0.34 1.2e-8 Morning vs. evening chronotype; CESC cis rs763121 0.853 rs2205802 chr22:39046327 T/C cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.36 0.5 3.44e-18 Menopause (age at onset); CESC cis rs11209002 0.614 rs7552205 chr1:67551741 C/A cg02640540 chr1:67518911 SLC35D1 0.45 5.24 0.31 3.29e-7 Crohn's disease; CESC cis rs546131 0.963 rs539044 chr11:34841542 G/T cg06937548 chr11:34938143 PDHX;APIP 0.53 6.78 0.38 7.84e-11 Lung disease severity in cystic fibrosis; CESC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg05373962 chr22:49881684 NA -0.38 -6.82 -0.39 6.24e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs4268898 0.760 rs4665675 chr2:24468132 C/T cg06627628 chr2:24431161 ITSN2 -0.52 -6.46 -0.37 5.01e-10 Asthma; CESC cis rs11252926 0.574 rs4881254 chr10:453567 C/T cg16386425 chr10:429943 DIP2C -0.57 -7.38 -0.41 2.09e-12 Psychosis in Alzheimer's disease; CESC cis rs731174 0.921 rs6686264 chr1:38192337 A/T cg12339802 chr1:38156545 C1orf109 -0.46 -5.69 -0.33 3.29e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg21138405 chr5:131827807 IRF1 0.54 9.32 0.5 4.74e-18 Asthma (sex interaction); CESC cis rs919433 0.963 rs10199410 chr2:198155776 A/T cg10820045 chr2:198174542 NA -0.41 -6.31 -0.36 1.14e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9457247 0.515 rs1951459 chr6:167402536 G/A cg23791538 chr6:167370224 RNASET2 0.65 9.13 0.49 1.77e-17 Crohn's disease; CESC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg10295955 chr4:187884368 NA -1.03 -20.7 -0.79 2.66e-57 Lobe attachment (rater-scored or self-reported); CESC cis rs1322639 0.806 rs1322640 chr6:169586887 T/C cg04662567 chr6:169592167 NA 0.52 6.83 0.39 5.66e-11 Pulse pressure; CESC cis rs11758351 0.518 rs79922979 chr6:26224975 A/G cg23601095 chr6:26197514 HIST1H3D 0.91 9.96 0.52 4.64e-20 Gout;Renal underexcretion gout; CESC cis rs3892630 0.878 rs1061686 chr19:33204544 C/T cg22980127 chr19:33182716 NUDT19 -0.95 -9.53 -0.51 1.07e-18 Red blood cell traits; CESC cis rs2486288 0.656 rs1706770 chr15:45575062 T/C cg09092052 chr15:45571596 NA 0.49 5.92 0.34 9.97e-9 Glomerular filtration rate; CESC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg06877462 chr1:205807181 PM20D1 0.4 5.65 0.33 4.22e-8 Menarche (age at onset); CESC cis rs793571 0.688 rs7179399 chr15:59165527 T/C cg05156742 chr15:59063176 FAM63B -0.5 -6.7 -0.38 1.26e-10 Schizophrenia; CESC cis rs35123781 1.000 rs9687282 chr5:139065988 T/G cg10513866 chr5:139070639 NA 0.38 5.68 0.33 3.45e-8 Schizophrenia; CESC cis rs1580019 0.523 rs13236410 chr7:32690663 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.49 6.21 0.36 2.07e-9 Cognitive ability; CESC cis rs9457247 0.765 rs10455982 chr6:167448728 C/T cg23791538 chr6:167370224 RNASET2 -0.55 -7.66 -0.43 3.42e-13 Crohn's disease; CESC cis rs11792861 0.926 rs7870597 chr9:111871864 T/C cg05043794 chr9:111880884 C9orf5 -0.42 -6.93 -0.39 3.22e-11 Menarche (age at onset); CESC cis rs9611565 0.592 rs9611612 chr22:41961189 T/C cg06481639 chr22:41940642 POLR3H -0.57 -6.29 -0.36 1.28e-9 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19756253 chr3:128118221 EEFSEC -0.61 -6.7 -0.38 1.26e-10 Gut microbiome composition (summer); CESC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg05332525 chr7:65337924 VKORC1L1 -0.47 -6.01 -0.35 6.07e-9 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17001531 chr1:16825540 NA 0.51 6.28 0.36 1.39e-9 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg05313129 chr8:58192883 C8orf71 -0.54 -6.22 -0.36 1.96e-9 Developmental language disorder (linguistic errors); CESC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 8.33 0.46 4.25e-15 Platelet count; CESC cis rs17376456 0.825 rs10052662 chr5:93271385 A/G cg25358565 chr5:93447407 FAM172A 1.13 10.22 0.53 6.99e-21 Diabetic retinopathy; CESC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg17949981 chr6:28129498 ZNF389 -0.49 -6.34 -0.36 9.94e-10 Depression; CESC cis rs11608355 0.618 rs7958220 chr12:109830980 T/C cg19025524 chr12:109796872 NA -0.55 -7.83 -0.43 1.17e-13 Neuroticism; CESC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg08470875 chr2:26401718 FAM59B 0.76 8.07 0.44 2.41e-14 Gut microbiome composition (summer); CESC cis rs4704187 0.663 rs28448485 chr5:74425775 G/A cg03227963 chr5:74354835 NA 0.31 5.77 0.33 2.21e-8 Response to amphetamines; CESC cis rs9393692 0.620 rs9379842 chr6:26289310 C/T cg00631329 chr6:26305371 NA 0.34 5.66 0.33 3.99e-8 Educational attainment; CESC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg18240062 chr17:79603768 NPLOC4 0.54 7.13 0.4 9.28e-12 Eye color traits; CESC cis rs7772486 0.625 rs2050027 chr6:146116113 C/G cg05347473 chr6:146136440 FBXO30 -0.53 -7.0 -0.39 2.13e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs8028182 0.636 rs4564532 chr15:75706296 C/G cg20655648 chr15:75932815 IMP3 0.49 6.39 0.37 7.49e-10 Sudden cardiac arrest; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg09326324 chr1:161123937 UFC1 -0.49 -6.58 -0.37 2.56e-10 Height; CESC cis rs6594499 0.872 rs10055177 chr5:110450584 T/G cg04022379 chr5:110408740 TSLP 0.32 5.67 0.33 3.82e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs589448 0.902 rs315131 chr12:69761839 T/G cg14784868 chr12:69753453 YEATS4 0.89 14.23 0.66 1.66e-34 Cerebrospinal fluid biomarker levels; CESC trans rs7944735 0.507 rs7396592 chr11:48100837 T/C cg15704280 chr7:45808275 SEPT13 -0.63 -7.63 -0.42 4.32e-13 Intraocular pressure; CESC cis rs892961 0.932 rs7224442 chr17:75413439 A/G cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg09177884 chr7:1199841 ZFAND2A -0.56 -7.28 -0.41 3.86e-12 Longevity;Endometriosis; CESC cis rs1005277 0.579 rs1780116 chr10:38526621 C/T cg25517755 chr10:38738941 LOC399744 -0.49 -6.39 -0.37 7.49e-10 Extrinsic epigenetic age acceleration; CESC trans rs1728785 1.000 rs1728764 chr16:68572292 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.44 0.42 1.41e-12 Ulcerative colitis; CESC cis rs9467711 0.606 rs9393711 chr6:26370659 C/T cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg07157834 chr1:205819609 PM20D1 -0.45 -6.06 -0.35 4.73e-9 Menarche (age at onset); CESC cis rs4727027 0.704 rs12535115 chr7:148895087 C/T cg23583168 chr7:148888333 NA -0.94 -16.97 -0.72 3.29e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs854765 0.547 rs2955353 chr17:17948979 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.81 -0.48 1.7e-16 Total body bone mineral density; CESC cis rs7223966 1.000 rs113134232 chr17:61715461 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 5.15 0.3 5.09e-7 Hip circumference adjusted for BMI;Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18222961 chr2:48009935 MSH6 0.57 6.11 0.35 3.46e-9 Gut microbiome composition (summer); CESC cis rs6547741 0.935 rs12714204 chr2:27787540 T/C cg21248554 chr2:27665150 KRTCAP3 0.25 5.26 0.31 3.04e-7 Oral cavity cancer; CESC cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg20476274 chr7:133979776 SLC35B4 0.64 9.32 0.5 4.89e-18 Mean platelet volume; CESC cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.46 7.65 0.43 3.71e-13 Monocyte percentage of white cells; CESC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg09658497 chr7:2847517 GNA12 -0.35 -5.09 -0.3 6.67e-7 Height; CESC cis rs4969178 0.896 rs12602206 chr17:76397133 A/G cg20026190 chr17:76395443 PGS1 0.49 7.78 0.43 1.67e-13 HDL cholesterol levels; CESC cis rs6545883 0.929 rs2593635 chr2:61634706 A/C cg15711740 chr2:61764176 XPO1 0.4 5.19 0.3 4.19e-7 Tuberculosis; CESC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg27535305 chr1:53392650 SCP2 0.36 6.31 0.36 1.14e-9 Monocyte count; CESC cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg21138405 chr5:131827807 IRF1 -0.63 -11.43 -0.57 7.32e-25 Asthma (sex interaction); CESC cis rs2204008 0.782 rs11514339 chr12:38236670 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.35 0.54 2.55e-21 Bladder cancer; CESC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg07677032 chr17:61819896 STRADA 0.45 5.9 0.34 1.1e-8 Prudent dietary pattern; CESC cis rs1881797 0.932 rs10925071 chr1:247686521 C/T cg18198730 chr1:247681584 NA -0.6 -8.55 -0.46 9.99e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs6088580 0.634 rs6059851 chr20:33047945 G/A cg08999081 chr20:33150536 PIGU 0.66 11.8 0.59 4.25e-26 Glomerular filtration rate (creatinine); CESC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 10.38 0.54 2.13e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs950027 0.620 rs35861938 chr15:45637343 T/C cg21132104 chr15:45694354 SPATA5L1 0.67 8.55 0.46 1.01e-15 Response to fenofibrate (adiponectin levels); CESC cis rs9811920 0.569 rs793445 chr3:99576644 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.52 -6.38 -0.36 8e-10 Axial length; CESC trans rs208515 0.525 rs12193034 chr6:66677866 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 11.12 0.56 7.77e-24 Exhaled nitric oxide levels; CESC cis rs11190604 1.000 rs11190595 chr10:102291761 T/C cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg09784724 chr6:90038647 UBE2J1 0.44 6.66 0.38 1.59e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg10351095 chr21:47802916 PCNT -0.48 -6.63 -0.38 1.83e-10 Testicular germ cell tumor; CESC cis rs17384381 1.000 rs12118950 chr1:85864519 T/C cg16011679 chr1:85725395 C1orf52 0.8 8.08 0.44 2.26e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.583 rs7503334 chr17:17779458 C/T cg04398451 chr17:18023971 MYO15A 0.64 8.99 0.48 4.72e-17 Total body bone mineral density; CESC cis rs1670533 1.000 rs2100411 chr4:1074412 T/C cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.88e-7 Recombination rate (females); CESC cis rs1059312 0.932 rs4760589 chr12:129284382 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -10.09 -0.53 1.81e-20 Systemic lupus erythematosus; CESC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.77 -8.65 -0.47 5e-16 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg09455208 chr3:40491958 NA 0.42 6.94 0.39 3.09e-11 Renal cell carcinoma; CESC cis rs9549367 0.826 rs2302755 chr13:113898418 C/T cg18105134 chr13:113819100 PROZ -0.69 -8.63 -0.47 5.68e-16 Platelet distribution width; CESC cis rs734999 0.505 rs10797439 chr1:2540364 G/A cg18854424 chr1:2615690 NA 0.3 5.99 0.35 6.97e-9 Ulcerative colitis; CESC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg11301795 chr4:187892539 NA -0.71 -11.21 -0.57 3.97e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs7647973 0.769 rs7434187 chr3:49032967 C/T cg07636037 chr3:49044803 WDR6 0.87 11.22 0.57 3.57e-24 Menarche (age at onset); CESC cis rs709400 0.930 rs2274268 chr14:104029378 C/G cg12935359 chr14:103987150 CKB -0.49 -6.35 -0.36 9.57e-10 Body mass index; CESC cis rs9837602 0.529 rs793495 chr3:99507934 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 9.77 0.51 1.87e-19 Breast cancer; CESC cis rs428668 0.523 rs6898671 chr5:150677643 A/T cg11125805 chr5:150678162 SLC36A3 0.7 11.11 0.56 8.41e-24 Skin aging (microtopography measurement); CESC cis rs6964587 1.000 rs7811564 chr7:91663364 A/G cg17063962 chr7:91808500 NA 0.6 8.31 0.45 4.96e-15 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13576045 chr11:9635311 NA -0.47 -6.92 -0.39 3.46e-11 Gambling; CESC cis rs9443189 0.723 rs2748947 chr6:76437921 C/T cg01950844 chr6:76311363 SENP6 -0.64 -7.04 -0.4 1.69e-11 Prostate cancer; CESC cis rs7191439 0.657 rs3826076 chr16:88780518 C/T cg02389323 chr16:88786976 FAM38A -0.72 -6.39 -0.37 7.56e-10 Plateletcrit; CESC cis rs9868809 0.881 rs57334642 chr3:48666795 C/T cg07636037 chr3:49044803 WDR6 -0.63 -5.15 -0.3 5.14e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs17253792 0.822 rs28549152 chr14:56091239 A/G cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs2072732 0.861 rs12034794 chr1:2937551 T/G cg03976712 chr1:2946727 NA 0.34 5.38 0.31 1.61e-7 Plateletcrit; CESC trans rs11098499 0.691 rs12510133 chr4:120271344 A/C cg25214090 chr10:38739885 LOC399744 0.6 8.3 0.45 5.33e-15 Corneal astigmatism; CESC cis rs763014 0.898 rs8060921 chr16:635988 C/A cg00908189 chr16:619842 PIGQ 0.65 9.02 0.48 4.04e-17 Height; CESC cis rs2625529 0.590 rs3803471 chr15:72500786 A/G cg16672083 chr15:72433130 SENP8 -0.4 -5.25 -0.31 3.08e-7 Red blood cell count; CESC cis rs9614461 0.826 rs9614649 chr22:45746097 C/A cg23503501 chr22:45809793 SMC1B;RIBC2 0.66 6.6 0.38 2.17e-10 Tonsillectomy; CESC cis rs2742234 0.868 rs2505512 chr10:43633596 G/A cg07801480 chr10:43725741 RASGEF1A 0.37 5.26 0.31 2.98e-7 Hirschsprung disease; CESC cis rs6121246 0.583 rs28815498 chr20:30351560 T/C cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.24e-24 Mean corpuscular hemoglobin; CESC cis rs4604732 0.631 rs74154672 chr1:247625625 C/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7843479 1.000 rs17615788 chr8:21814739 C/T cg17168535 chr8:21777572 XPO7 0.49 6.73 0.38 1.02e-10 Mean corpuscular volume; CESC cis rs2415984 0.622 rs1955262 chr14:46940639 A/G cg14871534 chr14:47121158 RPL10L -0.36 -5.42 -0.32 1.37e-7 Number of children ever born; CESC cis rs7336332 0.598 rs74183666 chr13:28007765 A/T cg01674679 chr13:27998804 GTF3A -0.59 -5.34 -0.31 1.99e-7 Weight; CESC cis rs12368653 0.525 rs1564374 chr12:58010163 C/T cg18357645 chr12:58087776 OS9 0.37 5.24 0.31 3.36e-7 Multiple sclerosis; CESC cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg05340658 chr4:99064831 C4orf37 0.82 13.05 0.63 2.08e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6674176 0.932 rs12410334 chr1:44442521 A/C cg13606994 chr1:44402422 ARTN -0.37 -5.45 -0.32 1.16e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9467711 0.606 rs9393712 chr6:26371000 G/C cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9487051 0.676 rs1521905 chr6:109594515 T/C cg01475377 chr6:109611718 NA -0.44 -6.99 -0.39 2.19e-11 Reticulocyte fraction of red cells; CESC cis rs2354432 0.660 rs10751415 chr1:146830785 T/A cg25205988 chr1:146714368 CHD1L 0.99 9.12 0.49 1.88e-17 Mitochondrial DNA levels; CESC cis rs2540647 0.561 rs2518802 chr22:18975345 A/C cg12798833 chr22:18958832 DGCR5 0.5 5.46 0.32 1.1e-7 Blood metabolite ratios; CESC cis rs2108622 0.727 rs62106157 chr19:15980448 G/A cg13772218 chr19:15982569 NA 0.3 5.87 0.34 1.27e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs897984 0.644 rs73524556 chr16:30823162 G/A cg00531865 chr16:30841666 NA -0.55 -8.33 -0.46 4.28e-15 Dementia with Lewy bodies; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24294819 chr8:117887282 RAD21 0.63 7.17 0.4 7.66e-12 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs78820104 chr14:56068854 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs1059312 1.000 rs7136092 chr12:129280164 G/C cg09035930 chr12:129282057 SLC15A4 0.76 10.73 0.55 1.59e-22 Systemic lupus erythematosus; CESC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.65 0.43 3.69e-13 Prudent dietary pattern; CESC cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.35 0.46 3.96e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg07697082 chr8:82753677 SNX16 -0.39 -5.32 -0.31 2.19e-7 Diastolic blood pressure; CESC cis rs2933343 0.700 rs876754 chr3:128627753 T/C cg25356066 chr3:128598488 ACAD9 0.6 8.46 0.46 1.79e-15 IgG glycosylation; CESC cis rs614226 1.000 rs591992 chr12:121019323 T/C cg01236616 chr12:121019343 POP5 1.49 18.26 0.75 8.44e-49 Type 1 diabetes nephropathy; CESC cis rs17253792 0.822 rs8009608 chr14:56062590 C/T cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC cis rs2354432 0.607 rs66486822 chr1:146802653 T/A cg25205988 chr1:146714368 CHD1L -1.03 -9.0 -0.48 4.56e-17 Mitochondrial DNA levels; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg09177884 chr7:1199841 ZFAND2A -0.7 -9.95 -0.52 4.89e-20 Longevity;Endometriosis; CESC cis rs62005083 1.000 rs62006762 chr14:74617438 A/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.66 5.24 0.31 3.3e-7 Mean corpuscular volume; CESC cis rs910316 0.763 rs4556 chr14:75476071 G/C cg16144293 chr14:75469539 EIF2B2 -0.39 -5.2 -0.3 3.96e-7 Height; CESC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg18099408 chr3:52552593 STAB1 0.34 5.74 0.33 2.54e-8 Electroencephalogram traits; CESC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg04944784 chr2:26401820 FAM59B -0.96 -10.46 -0.54 1.19e-21 Gut microbiome composition (summer); CESC cis rs17854409 1.000 rs6010770 chr20:61494225 G/T cg05147244 chr20:61493195 TCFL5 0.9 6.48 0.37 4.57e-10 Obesity-related traits; CESC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg02187348 chr16:89574699 SPG7 0.62 8.67 0.47 4.33e-16 Multiple myeloma (IgH translocation); CESC cis rs11608355 0.515 rs11610558 chr12:109925865 C/T cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs6991838 0.584 rs35941313 chr8:66499733 G/T cg13398993 chr8:66546079 ARMC1 -0.48 -5.77 -0.33 2.22e-8 Intelligence (multi-trait analysis); CESC cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg16386425 chr10:429943 DIP2C -0.45 -5.75 -0.33 2.46e-8 Psychosis in Alzheimer's disease; CESC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg11494091 chr17:61959527 GH2 0.39 5.61 0.33 5.06e-8 Height; CESC cis rs2380220 0.872 rs7750757 chr6:95997118 A/G cg15832292 chr6:96025679 MANEA 0.7 6.74 0.38 9.88e-11 Behavioural disinhibition (generation interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21939482 chr7:6388130 C7orf70 -0.52 -7.7 -0.43 2.73e-13 Gambling; CESC cis rs7605827 0.930 rs10208972 chr2:15676686 G/A cg19274914 chr2:15703543 NA 0.38 6.72 0.38 1.08e-10 Educational attainment (years of education); CESC cis rs2124969 0.548 rs983916 chr2:161015066 T/G cg03641300 chr2:160917029 PLA2R1 -0.58 -6.01 -0.35 6.14e-9 Waist circumference adjusted for body mass index; CESC cis rs7640424 0.649 rs62262420 chr3:107909940 C/T cg09227934 chr3:107805635 CD47 -0.45 -5.67 -0.33 3.73e-8 Body mass index; CESC cis rs8180040 1.000 rs2302278 chr3:47361082 G/T cg27129171 chr3:47204927 SETD2 -0.64 -9.73 -0.51 2.57e-19 Colorectal cancer; CESC cis rs7937682 0.632 rs10891297 chr11:111770150 C/T cg22437258 chr11:111473054 SIK2 -0.5 -5.52 -0.32 8.11e-8 Primary sclerosing cholangitis; CESC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg16145915 chr7:1198662 ZFAND2A -0.61 -9.36 -0.5 3.46e-18 Longevity;Endometriosis; CESC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg04369109 chr6:150039330 LATS1 -0.43 -5.99 -0.35 6.69e-9 Lung cancer; CESC cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg13119609 chr19:45449297 APOC2 0.47 7.7 0.43 2.64e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9303401 0.538 rs10515155 chr17:56481944 A/G cg25039879 chr17:56429692 SUPT4H1 0.63 6.49 0.37 4.2e-10 Cognitive test performance; CESC cis rs11696845 0.626 rs6073537 chr20:43378270 A/G cg25301532 chr20:43378953 KCNK15 -0.36 -5.86 -0.34 1.36e-8 Obesity-related traits; CESC cis rs2625529 0.590 rs2856929 chr15:72496762 T/C cg16672083 chr15:72433130 SENP8 -0.42 -5.53 -0.32 7.78e-8 Red blood cell count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04104609 chr2:219523980 ZNF142;BCS1L -0.45 -6.45 -0.37 5.19e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2880765 0.566 rs12911430 chr15:86011264 A/T cg19183879 chr15:85880815 NA -0.31 -5.9 -0.34 1.12e-8 Coronary artery disease; CESC cis rs7116495 0.609 rs628025 chr11:71802351 A/C cg10381502 chr11:71823885 C11orf51 -1.08 -6.75 -0.38 9.47e-11 Severe influenza A (H1N1) infection; CESC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13319197 chr11:46142000 PHF21A 0.63 7.35 0.41 2.42e-12 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10668512 chr15:42565522 GANC;TMEM87A 0.47 6.22 0.36 1.9e-9 Systemic lupus erythematosus; CESC cis rs5758659 0.714 rs5758578 chr22:42490292 A/C cg04733989 chr22:42467013 NAGA -0.44 -6.16 -0.35 2.63e-9 Cognitive function; CESC cis rs61931739 0.817 rs11833948 chr12:34276942 G/T cg19457237 chr12:34500585 NA -0.39 -5.38 -0.31 1.65e-7 Morning vs. evening chronotype; CESC cis rs7833986 0.501 rs2976018 chr8:57014752 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.54 0.42 7.58e-13 Height; CESC cis rs7829975 0.777 rs486781 chr8:8639740 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -5.55 -0.32 6.79e-8 Mood instability; CESC trans rs681383 1.000 rs58102861 chr18:8331365 C/T cg27042584 chr16:51168485 NA 0.49 5.99 0.35 6.68e-9 Sitting height ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05049160 chr22:36693009 MYH9 -0.48 -6.35 -0.36 9.44e-10 Gut microbiome composition (summer); CESC trans rs11098499 0.863 rs6853998 chr4:120475860 C/A cg25214090 chr10:38739885 LOC399744 0.66 9.03 0.49 3.57e-17 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18887680 chr5:78907942 PAPD4 -0.57 -6.7 -0.38 1.24e-10 Gut microbiome composition (summer); CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg25485084 chr12:118809325 TAOK3 -0.47 -6.2 -0.36 2.1e-9 Subjective well-being; CESC cis rs853679 0.505 rs200992 chr6:27814677 A/G cg26587870 chr6:27730563 NA -0.62 -5.31 -0.31 2.33e-7 Depression; CESC cis rs9611565 0.694 rs202637 chr22:41853928 A/G cg03806693 chr22:41940476 POLR3H 1.2 14.33 0.66 7.01e-35 Vitiligo; CESC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg26335602 chr6:28129616 ZNF389 0.54 7.25 0.41 4.45e-12 Depression; CESC cis rs7044106 0.648 rs2031369 chr9:123360294 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 9.35 0.5 3.69e-18 Hip circumference adjusted for BMI; CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg16145915 chr7:1198662 ZFAND2A -0.54 -6.6 -0.38 2.26e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg08859206 chr1:53392774 SCP2 -0.56 -7.33 -0.41 2.8e-12 Monocyte count; CESC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Tonsillectomy; CESC cis rs7809950 0.906 rs2253269 chr7:107201114 C/T cg23024343 chr7:107201750 COG5 -0.41 -5.72 -0.33 2.85e-8 Coronary artery disease; CESC cis rs11583043 0.575 rs12727971 chr1:101589175 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.48 5.32 0.31 2.25e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs9733 0.744 rs11204737 chr1:150847647 C/T cg22823121 chr1:150693482 HORMAD1 -0.37 -5.45 -0.32 1.15e-7 Tonsillectomy; CESC cis rs7904368 0.806 rs45495501 chr10:16861476 G/A cg23933602 chr10:16859644 RSU1 0.66 5.76 0.33 2.3e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC trans rs8014252 0.667 rs2877657 chr14:70823932 A/G cg03123320 chr1:229394665 NA -0.46 -6.04 -0.35 5.13e-9 Plasma estrone levels in resected estrogen-receptor positive breast cancer; CESC cis rs910316 1.000 rs7145159 chr14:75583268 A/G cg11812906 chr14:75593930 NEK9 0.9 15.69 0.69 1.08e-39 Height; CESC cis rs3768617 0.510 rs10911249 chr1:183080690 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.96 0.65 1.41e-33 Fuchs's corneal dystrophy; CESC cis rs9926296 0.715 rs2115401 chr16:89740609 A/G cg03605463 chr16:89740564 NA -0.57 -7.15 -0.4 8.48e-12 Vitiligo; CESC cis rs2479106 0.791 rs56944968 chr9:126712126 G/A cg16191174 chr9:126692580 DENND1A 0.42 5.64 0.33 4.33e-8 Polycystic ovary syndrome; CESC cis rs6120849 0.754 rs1885116 chr20:33600560 A/G cg24642439 chr20:33292090 TP53INP2 0.67 6.69 0.38 1.3e-10 Protein C levels; CESC cis rs870825 0.616 rs7681824 chr4:185617525 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg13175981 chr1:150552382 MCL1 0.44 5.28 0.31 2.76e-7 Urate levels; CESC cis rs72781680 0.898 rs12619592 chr2:23971415 C/A cg20701182 chr2:24300061 SF3B14 0.62 5.49 0.32 9.46e-8 Lymphocyte counts; CESC cis rs7769051 1.000 rs7769051 chr6:133146796 G/T cg07930552 chr6:133119739 C6orf192 0.72 7.2 0.4 6.09e-12 Type 2 diabetes nephropathy; CESC cis rs9287719 0.967 rs7605461 chr2:10738134 G/A cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs7772486 0.790 rs2485632 chr6:146193228 A/G cg23711669 chr6:146136114 FBXO30 1.01 15.47 0.69 6.84e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.46 6.13 0.35 3.1e-9 Eosinophil percentage of white cells; CESC cis rs10242455 0.850 rs57367781 chr7:99116819 G/A cg25640893 chr7:99214727 ZNF498 0.71 5.19 0.3 4.21e-7 Blood metabolite levels; CESC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.63 0.38 1.87e-10 Prudent dietary pattern; CESC cis rs400736 0.576 rs10864328 chr1:8164456 G/C cg25007680 chr1:8021821 PARK7 -0.45 -5.89 -0.34 1.15e-8 Response to antidepressants and depression; CESC cis rs12347191 0.500 rs907582 chr9:100621926 T/C cg13688889 chr9:100608707 NA -0.91 -13.28 -0.63 3.27e-31 Orofacial clefts; CESC cis rs55665837 0.583 rs78843135 chr11:14411254 T/G cg19336497 chr11:14380999 RRAS2 -0.36 -5.28 -0.31 2.64e-7 Vitamin D levels; CESC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg04511125 chr2:88470314 THNSL2 -0.52 -7.7 -0.43 2.77e-13 Response to metformin (IC50); CESC cis rs644799 0.525 rs3016206 chr11:95536724 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.74 10.63 0.55 3.24e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9486719 0.947 rs2472908 chr6:96875998 A/T cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 1.000 rs6503887 chr17:56993320 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.81 -0.39 6.5500000000000006e-11 Intelligence (multi-trait analysis); CESC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg07395648 chr5:131743802 NA -0.43 -5.41 -0.32 1.38e-7 Breast cancer;Mosquito bite size; CESC cis rs9457247 1.000 rs407515 chr6:167407544 G/C cg23791538 chr6:167370224 RNASET2 -0.61 -8.81 -0.48 1.71e-16 Crohn's disease; CESC cis rs78456975 0.739 rs13405352 chr2:1518726 C/T cg01028140 chr2:1542097 TPO -0.52 -5.71 -0.33 3.04e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9318086 0.776 rs1326130 chr13:24447664 A/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.39 5.66 0.33 3.95e-8 Myopia (pathological); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg16116244 chr1:16939841 NBPF1 0.52 6.05 0.35 4.84e-9 Psoriatic arthritis; CESC cis rs6987853 0.933 rs2923430 chr8:42391195 T/C cg09913449 chr8:42400586 C8orf40 0.4 6.34 0.36 9.76e-10 Mean corpuscular hemoglobin concentration; CESC cis rs1348850 0.914 rs10194648 chr2:178337031 G/A cg23306229 chr2:178417860 TTC30B 0.66 8.36 0.46 3.59e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10504229 0.516 rs4361758 chr8:57990401 C/T cg24829409 chr8:58192753 C8orf71 -0.36 -5.11 -0.3 6.21e-7 Developmental language disorder (linguistic errors); CESC cis rs929354 1.000 rs1182381 chr7:157043473 G/A cg05182265 chr7:156933206 UBE3C 0.43 5.84 0.34 1.49e-8 Body mass index; CESC cis rs113835537 0.529 rs2277302 chr11:66240882 T/C cg24851651 chr11:66362959 CCS 0.46 5.98 0.35 7.05e-9 Airway imaging phenotypes; CESC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg20151795 chr6:28129481 ZNF389 0.45 5.7 0.33 3.12e-8 Depression; CESC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg11742103 chr11:62369870 EML3;MTA2 0.65 9.67 0.51 3.75e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.85 0.34 1.47e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9486719 1.000 rs2499816 chr6:96878206 C/T cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs7923609 0.846 rs7090111 chr10:65077994 C/G cg01631684 chr10:65280961 REEP3 -0.43 -5.38 -0.31 1.6e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs2463822 0.513 rs72919445 chr11:62029078 A/C cg06239285 chr11:62104954 ASRGL1 -0.96 -7.69 -0.43 2.93e-13 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs11191270 0.554 rs11191274 chr10:104140350 G/A cg15320455 chr10:103880129 LDB1 0.7 5.69 0.33 3.32e-8 Intelligence (multi-trait analysis); CESC cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -6.13 -0.35 3.2e-9 Mood instability; CESC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg23248424 chr5:179741104 GFPT2 -0.57 -7.86 -0.43 9.98e-14 Height; CESC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg27170947 chr2:26402098 FAM59B 0.87 9.93 0.52 5.78e-20 Gut microbiome composition (summer); CESC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg11168104 chr5:1857477 NA -0.38 -5.65 -0.33 4.15e-8 Cardiovascular disease risk factors; CESC cis rs4699052 0.625 rs28397882 chr4:104282836 G/A cg16532752 chr4:104119610 CENPE -0.37 -5.3 -0.31 2.46e-7 Testicular germ cell tumor; CESC cis rs4654899 0.802 rs2167811 chr1:21194510 A/G cg05370193 chr1:21551575 ECE1 -0.37 -5.41 -0.32 1.43e-7 Superior frontal gyrus grey matter volume; CESC cis rs4727963 0.792 rs12667916 chr7:122740976 A/G cg03640110 chr7:122635026 TAS2R16 0.4 6.2 0.36 2.14e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Depression; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26203883 chr20:36156320 BLCAP -0.48 -6.11 -0.35 3.61e-9 Fibrinogen levels; CESC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg06481639 chr22:41940642 POLR3H -0.62 -6.8 -0.39 6.94e-11 Vitiligo; CESC cis rs2797160 0.967 rs6910786 chr6:126017141 A/T cg05901451 chr6:126070800 HEY2 0.46 6.58 0.37 2.44e-10 Endometrial cancer; CESC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg04398451 chr17:18023971 MYO15A -0.61 -8.31 -0.45 5.04e-15 Total body bone mineral density; CESC cis rs1008375 1.000 rs6818639 chr4:17633049 A/G cg15017067 chr4:17643749 FAM184B 0.36 5.19 0.3 4.25e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7044106 0.708 rs920745 chr9:123429943 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 12.82 0.62 1.3e-29 Hip circumference adjusted for BMI; CESC cis rs11719291 0.833 rs73080361 chr3:48832146 G/A cg00383909 chr3:49044727 WDR6 0.89 5.53 0.32 7.75e-8 Cognitive function; CESC cis rs4808199 0.948 rs2301668 chr19:19452249 G/A cg03709012 chr19:19516395 GATAD2A 1.13 12.03 0.59 6.84e-27 Nonalcoholic fatty liver disease; CESC trans rs1945213 0.694 rs17149976 chr11:55839746 T/C cg15704280 chr7:45808275 SEPT13 0.76 7.31 0.41 3.15e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs6736093 0.966 rs11686647 chr2:112684397 T/A cg12686935 chr2:112915763 FBLN7 -0.43 -5.56 -0.32 6.75e-8 Coronary artery disease; CESC cis rs7267979 1.000 rs6076339 chr20:25348712 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -17.1 -0.72 1.14e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs72781680 0.898 rs12619525 chr2:23999565 G/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs4253772 0.591 rs8143066 chr22:46656607 C/T cg24881330 chr22:46731750 TRMU 0.88 10.03 0.52 2.79e-20 LDL cholesterol;Cholesterol, total; CESC cis rs3733585 0.699 rs4473653 chr4:9971058 A/G cg11266682 chr4:10021025 SLC2A9 -0.57 -10.58 -0.54 4.9e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10883723 0.810 rs2296590 chr10:104262628 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs919433 0.783 rs787980 chr2:198239225 C/T cg10820045 chr2:198174542 NA 0.41 5.98 0.34 7.35e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg12923728 chr3:195709715 SDHAP1 -0.67 -8.99 -0.48 4.91e-17 Pancreatic cancer; CESC cis rs2294693 0.945 rs10947944 chr6:41004657 T/C cg14769373 chr6:40998127 UNC5CL -0.47 -6.17 -0.35 2.5e-9 Gastric cancer;Non-cardia gastric cancer; CESC cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg18876405 chr7:65276391 NA 0.56 7.27 0.41 3.94e-12 Aortic root size; CESC trans rs116095464 0.614 rs10067482 chr5:219328 T/G cg00938859 chr5:1591904 SDHAP3 0.6 6.66 0.38 1.55e-10 Breast cancer; CESC trans rs13398848 1.000 rs76942868 chr2:84201661 G/A cg23262351 chr6:79576851 IRAK1BP1 -0.69 -6.08 -0.35 4.1e-9 Conduct disorder (symptom count);Conduct disorder; CESC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg17971929 chr21:40555470 PSMG1 -0.85 -12.27 -0.6 1.01e-27 Cognitive function; CESC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.52 -6.67 -0.38 1.46e-10 Platelet count; CESC cis rs12711979 0.509 rs13000873 chr2:3823705 T/C cg17052675 chr2:3827356 NA -0.66 -11.01 -0.56 1.79e-23 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs902774 0.554 rs4503623 chr12:53353759 T/C cg25025879 chr12:53359317 NA -0.49 -6.45 -0.37 5.28e-10 Prostate cancer; CESC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg17724175 chr1:150552817 MCL1 0.41 6.7 0.38 1.28e-10 Tonsillectomy; CESC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg21782813 chr7:2030301 MAD1L1 0.5 7.23 0.41 5.12e-12 Bipolar disorder and schizophrenia; CESC cis rs11098499 0.580 rs12509234 chr4:120319434 T/C cg09307838 chr4:120376055 NA 0.91 12.36 0.6 5.06e-28 Corneal astigmatism; CESC cis rs6728642 1.000 rs11900461 chr2:97615993 C/T cg26665480 chr2:98280029 ACTR1B -0.73 -6.14 -0.35 2.94e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs12216125 0.554 rs6942196 chr6:26072804 A/G cg16482183 chr6:26056742 HIST1H1C 0.39 5.31 0.31 2.35e-7 Iron status biomarkers; CESC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg03609598 chr5:56110824 MAP3K1 -0.52 -5.22 -0.31 3.71e-7 Initial pursuit acceleration; CESC cis rs17125944 0.505 rs74620173 chr14:53194068 G/T cg00686598 chr14:53173677 PSMC6 1.36 11.76 0.59 5.6e-26 Alzheimer's disease (late onset); CESC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg08859206 chr1:53392774 SCP2 -0.63 -8.36 -0.46 3.53e-15 Monocyte count; CESC cis rs9914988 0.943 rs7217547 chr17:27106872 C/G cg20469991 chr17:27169893 C17orf63 -0.43 -5.24 -0.31 3.27e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs6750047 0.546 rs1367696 chr2:38286914 C/T cg07380506 chr2:38303506 CYP1B1 0.46 5.9 0.34 1.12e-8 Cutaneous malignant melanoma;Melanoma; CESC cis rs7520050 0.897 rs4440807 chr1:46470878 T/C cg03146154 chr1:46216737 IPP -0.46 -5.87 -0.34 1.31e-8 Red blood cell count;Reticulocyte count; CESC cis rs72781680 0.611 rs72781696 chr2:24267014 C/T cg06627628 chr2:24431161 ITSN2 -0.65 -6.21 -0.36 2.08e-9 Lymphocyte counts; CESC cis rs9814567 0.964 rs6776203 chr3:134234345 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.15 -0.35 2.79e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs10927875 0.632 rs4661667 chr1:16162731 C/T cg18973939 chr1:16164122 FLJ37453 0.36 5.5 0.32 8.96e-8 Dilated cardiomyopathy; CESC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg25036284 chr2:26402008 FAM59B -0.84 -9.59 -0.51 7.03e-19 Gut microbiome composition (summer); CESC cis rs7309 0.622 rs4664396 chr2:161901650 C/T cg22496339 chr2:162101262 NA -0.4 -5.06 -0.3 7.81e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CESC cis rs2070997 0.607 rs72765060 chr9:133712404 T/C cg11464064 chr9:133710261 ABL1 0.71 7.92 0.44 6.42e-14 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03855276 chr3:51705097 TEX264 0.62 6.7 0.38 1.23e-10 Gut microbiome composition (summer); CESC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Tonsillectomy; CESC cis rs3806843 0.735 rs801167 chr5:140081423 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.06 -0.3 7.79e-7 Depressive symptoms (multi-trait analysis); CESC cis rs523522 0.962 rs11065154 chr12:120971417 T/C cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg02951883 chr7:2050386 MAD1L1 -0.39 -5.2 -0.3 4.04e-7 Bipolar disorder and schizophrenia; CESC trans rs61931739 0.500 rs11053217 chr12:34470036 A/C cg26384229 chr12:38710491 ALG10B 0.55 7.57 0.42 6.05e-13 Morning vs. evening chronotype; CESC cis rs826838 0.935 rs1843639 chr12:39178919 C/A cg26384229 chr12:38710491 ALG10B 0.78 13.22 0.63 5.37e-31 Heart rate; CESC cis rs2243480 1.000 rs778679 chr7:65840911 A/G cg13147721 chr7:65941812 NA -0.95 -8.95 -0.48 6.27e-17 Diabetic kidney disease; CESC cis rs2522056 1.000 rs886286 chr5:131795597 A/G cg24060327 chr5:131705240 SLC22A5 0.59 6.63 0.38 1.85e-10 Lymphocyte counts;Fibrinogen; CESC cis rs208520 0.837 rs208509 chr6:66941706 A/G cg07460842 chr6:66804631 NA -0.82 -9.92 -0.52 6.45e-20 Exhaled nitric oxide output; CESC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg23978390 chr7:1156363 C7orf50 0.51 6.84 0.39 5.58e-11 Longevity;Endometriosis; CESC cis rs9322193 0.607 rs4870078 chr6:150201812 A/G cg01145232 chr6:150245071 RAET1G -0.45 -5.42 -0.32 1.35e-7 Lung cancer; CESC cis rs2839186 0.934 rs17176520 chr21:47682081 T/C cg00815214 chr21:47717953 NA -0.35 -5.19 -0.3 4.17e-7 Testicular germ cell tumor; CESC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03934478 chr11:495069 RNH1 0.52 5.19 0.3 4.26e-7 Body mass index; CESC cis rs897080 0.515 rs1067345 chr2:44618897 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 5.94 0.34 8.71e-9 Height; CESC cis rs7953249 0.656 rs2243616 chr12:121406370 G/T cg25281562 chr12:121454272 C12orf43 -0.46 -5.73 -0.33 2.78e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs2439831 0.867 rs2243434 chr15:43689867 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.91 11.14 0.56 6.61e-24 Lung cancer in ever smokers; CESC cis rs763121 0.853 rs6001204 chr22:39100239 T/C cg06022373 chr22:39101656 GTPBP1 0.95 17.82 0.74 3.23e-47 Menopause (age at onset); CESC cis rs2635047 0.811 rs28471970 chr18:44788439 G/C cg24371990 chr18:44770781 NA 0.41 6.53 0.37 3.34e-10 Educational attainment; CESC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg18252515 chr7:66147081 NA -0.46 -6.2 -0.36 2.15e-9 Aortic root size; CESC cis rs61931739 0.534 rs4001713 chr12:34154195 A/C cg19457237 chr12:34500585 NA 0.4 5.53 0.32 7.53e-8 Morning vs. evening chronotype; CESC cis rs17407555 0.606 rs3775945 chr4:10011996 A/T cg11266682 chr4:10021025 SLC2A9 -0.47 -5.69 -0.33 3.28e-8 Schizophrenia (age at onset); CESC cis rs2294693 0.853 rs9296350 chr6:40977623 G/A cg14769373 chr6:40998127 UNC5CL -0.43 -5.87 -0.34 1.27e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs9611565 0.559 rs132768 chr22:42013523 C/A cg03806693 chr22:41940476 POLR3H 1.08 12.76 0.62 2.14e-29 Vitiligo; CESC cis rs4523957 0.583 rs2760740 chr17:2020989 A/G cg16513277 chr17:2031491 SMG6 -0.7 -9.8 -0.52 1.47e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg04455712 chr21:45112962 RRP1B 0.4 5.87 0.34 1.28e-8 Mean corpuscular volume; CESC trans rs61931739 0.500 rs11053177 chr12:34412829 G/A cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.75e-12 Morning vs. evening chronotype; CESC cis rs36051895 0.632 rs10115335 chr9:5140963 A/T cg02405213 chr9:5042618 JAK2 -0.48 -6.12 -0.35 3.39e-9 Pediatric autoimmune diseases; CESC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg11494091 chr17:61959527 GH2 0.44 6.35 0.36 9.23e-10 Height; CESC cis rs977987 0.778 rs8057849 chr16:75443816 T/C cg03315344 chr16:75512273 CHST6 0.41 5.86 0.34 1.35e-8 Dupuytren's disease; CESC cis rs637571 0.522 rs566590 chr11:65754062 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.53 0.37 3.42e-10 Eosinophil percentage of white cells; CESC cis rs7949030 0.596 rs11231137 chr11:62315699 G/A cg22862634 chr11:62369728 EML3;MTA2 0.47 6.21 0.36 2.02e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2425143 0.908 rs6060605 chr20:34378132 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -7.4 -0.41 1.77e-12 Blood protein levels; CESC cis rs17376456 0.877 rs17374627 chr5:93296306 C/T cg25358565 chr5:93447407 FAM172A 1.09 10.18 0.53 9.53e-21 Diabetic retinopathy; CESC cis rs13102973 0.965 rs6853276 chr4:135881445 A/T cg14419869 chr4:135874104 NA 0.35 5.57 0.32 6.18e-8 Subjective well-being; CESC cis rs9682041 0.696 rs6774380 chr3:170091644 T/A cg11886554 chr3:170076028 SKIL 0.7 6.49 0.37 4.1e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs2070488 1.000 rs6772046 chr3:38479660 C/T cg24069376 chr3:38537580 EXOG 0.46 8.26 0.45 7.14e-15 Electrocardiographic conduction measures; CESC cis rs6540559 0.673 rs17015309 chr1:210007218 C/T cg22029157 chr1:209979665 IRF6 0.71 7.61 0.42 4.72e-13 Cleft lip with or without cleft palate; CESC cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg23711669 chr6:146136114 FBXO30 -1.01 -15.7 -0.69 1.03e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs1003719 0.762 rs6517402 chr21:38447423 A/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.71 0.47 3.4e-16 Eye color traits; CESC cis rs4919694 0.572 rs12262258 chr10:104900272 G/A cg04362960 chr10:104952993 NT5C2 0.63 6.25 0.36 1.66e-9 Arsenic metabolism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08885106 chr8:144550663 ZC3H3 -0.56 -6.59 -0.38 2.31e-10 Gut microbiome composition (summer); CESC cis rs9916302 0.706 rs6503500 chr17:37485925 C/T cg07936489 chr17:37558343 FBXL20 -0.91 -10.22 -0.53 7.02e-21 Glomerular filtration rate (creatinine); CESC cis rs12474201 0.832 rs4952843 chr2:46957845 A/G cg06386533 chr2:46925753 SOCS5 0.84 11.6 0.58 1.9e-25 Height; CESC cis rs2439831 0.681 rs484029 chr15:43619560 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.07 0.63 1.81e-30 Lung cancer in ever smokers; CESC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg23048001 chr7:2026167 MAD1L1 0.45 5.89 0.34 1.16e-8 Schizophrenia; CESC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.23 0.31 3.41e-7 Menopause (age at onset); CESC cis rs425277 0.917 rs12410859 chr1:2038732 C/T cg16545954 chr1:2118288 C1orf86 0.33 5.39 0.31 1.56e-7 Height; CESC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.23 0.53 6.6e-21 Prudent dietary pattern; CESC cis rs977987 0.872 rs7206665 chr16:75475287 A/C cg03315344 chr16:75512273 CHST6 0.42 6.02 0.35 5.67e-9 Dupuytren's disease; CESC cis rs703842 0.892 rs1021469 chr12:58208164 C/T cg00677455 chr12:58241039 CTDSP2 0.53 6.77 0.38 8.13e-11 Multiple sclerosis; CESC cis rs17376456 0.825 rs10054790 chr5:93272520 A/G cg25358565 chr5:93447407 FAM172A 1.16 10.12 0.53 1.48e-20 Diabetic retinopathy; CESC cis rs7829975 0.582 rs11783950 chr8:8597831 A/C cg15556689 chr8:8085844 FLJ10661 -0.43 -5.25 -0.31 3.18e-7 Mood instability; CESC trans rs853679 0.546 rs34371502 chr6:28081758 T/C cg01620082 chr3:125678407 NA -0.81 -6.34 -0.36 1.01e-9 Depression; CESC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.52 0.37 3.61e-10 Prudent dietary pattern; CESC cis rs9611565 0.546 rs739132 chr22:42123099 A/T cg03806693 chr22:41940476 POLR3H 1.14 13.61 0.64 2.45e-32 Vitiligo; CESC cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg10523679 chr1:76189770 ACADM 0.7 6.97 0.39 2.5e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1348850 0.651 rs1901824 chr2:178225466 T/C cg22681709 chr2:178499509 PDE11A -0.39 -5.89 -0.34 1.15e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs7980799 0.935 rs2892701 chr12:33547395 C/T cg26384229 chr12:38710491 ALG10B 0.44 6.25 0.36 1.66e-9 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs4692589 1.000 rs4692589 chr4:170935245 C/T cg19918862 chr4:170955249 NA -0.36 -5.71 -0.33 2.97e-8 Anxiety disorder; CESC cis rs1401999 0.510 rs2293001 chr3:183700211 C/T cg01324343 chr3:183735012 ABCC5 0.39 6.72 0.38 1.11e-10 Anterior chamber depth; CESC trans rs4904167 0.812 rs12881717 chr14:84668514 G/A cg19167227 chr15:84044884 NA -0.43 -6.19 -0.36 2.27e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7949030 0.504 rs2516633 chr11:62371773 A/C cg02375832 chr11:62437615 C11orf48 0.38 5.48 0.32 1.01e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.46 -6.04 -0.35 5.26e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg08736216 chr1:53307985 ZYG11A 0.43 7.25 0.41 4.64e-12 Monocyte count; CESC cis rs3747547 0.786 rs72726024 chr9:38020824 G/T cg13774184 chr9:37916125 SHB -0.73 -6.25 -0.36 1.61e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs1153858 1.000 rs12437840 chr15:45669055 C/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg17644776 chr2:200775616 C2orf69 -0.54 -6.63 -0.38 1.84e-10 Osteoporosis; CESC trans rs8073060 0.545 rs3859282 chr17:34006111 T/C cg19694781 chr19:47549865 TMEM160 -0.71 -6.74 -0.38 9.95e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs36051895 0.659 rs12343065 chr9:5083533 C/T cg02405213 chr9:5042618 JAK2 -0.55 -6.66 -0.38 1.58e-10 Pediatric autoimmune diseases; CESC cis rs75804782 0.572 rs72982580 chr2:239447783 A/G cg18131467 chr2:239335373 ASB1 -0.69 -5.55 -0.32 6.89e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg07507251 chr3:52567010 NT5DC2 -0.33 -5.41 -0.32 1.42e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13173722 chr20:60553138 TAF4 -0.62 -6.84 -0.39 5.38e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00745463 chr17:30367425 LRRC37B -0.57 -6.39 -0.37 7.48e-10 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 7.19 0.4 6.49e-12 Personality dimensions; CESC cis rs10097731 0.808 rs80141261 chr8:82034453 T/C cg25230327 chr8:82042993 NA -0.6 -7.01 -0.4 1.98e-11 Serum total protein level; CESC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg26314531 chr2:26401878 FAM59B -0.85 -9.04 -0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs55871839 0.533 rs7813733 chr8:59852429 C/T cg07426533 chr8:59803705 TOX 0.41 5.33 0.31 2.12e-7 Pneumonia; CESC cis rs4481887 1.000 rs4474293 chr1:248470438 T/C cg00666640 chr1:248458726 OR2T12 0.39 6.36 0.36 8.71e-10 Common traits (Other); CESC cis rs4835473 0.868 rs1822841 chr4:144842638 G/T cg25736465 chr4:144833511 NA 0.46 7.16 0.4 7.86e-12 Immature fraction of reticulocytes; CESC cis rs910316 1.000 rs7147118 chr14:75610170 G/C cg11812906 chr14:75593930 NEK9 0.92 16.16 0.7 2.31e-41 Height; CESC cis rs9611565 0.921 rs5751077 chr22:41720728 G/C cg03806693 chr22:41940476 POLR3H -0.67 -8.06 -0.44 2.57e-14 Vitiligo; CESC cis rs2732480 0.557 rs2634682 chr12:48732943 T/C cg04545296 chr12:48745243 ZNF641 0.44 7.22 0.41 5.36e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2835872 0.758 rs8134288 chr21:39036989 T/C cg06728970 chr21:39037746 KCNJ6 0.3 5.53 0.32 7.57e-8 Electroencephalographic traits in alcoholism; CESC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg02269571 chr22:50332266 NA 0.47 6.19 0.36 2.34e-9 Schizophrenia; CESC trans rs10841784 0.917 rs7962919 chr12:21466507 G/A cg00566759 chr18:28682345 DSC2 0.48 6.61 0.38 2.13e-10 Childhood ear infection; CESC cis rs870825 0.616 rs2310108 chr4:185639475 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg10578991 chr7:12443926 VWDE -0.49 -6.22 -0.36 1.91e-9 Coronary artery disease; CESC trans rs9858542 0.953 rs9837341 chr3:49664767 A/G cg21659725 chr3:3221576 CRBN -0.52 -6.3 -0.36 1.21e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.69 7.77 0.43 1.78e-13 Alzheimer's disease; CESC cis rs6088580 0.634 rs6087577 chr20:32955423 C/T cg06115741 chr20:33292138 TP53INP2 0.45 5.71 0.33 3e-8 Glomerular filtration rate (creatinine); CESC cis rs7546094 1.000 rs6537743 chr1:113092527 A/G cg22162597 chr1:113214053 CAPZA1 0.37 5.67 0.33 3.73e-8 Platelet distribution width; CESC trans rs7618501 0.538 rs9856572 chr3:50109073 A/T cg21659725 chr3:3221576 CRBN -0.5 -7.03 -0.4 1.75e-11 Intelligence (multi-trait analysis); CESC cis rs77106637 0.860 rs75896506 chr11:72429579 G/A cg03713592 chr11:72463424 ARAP1 1.21 10.49 0.54 9.08e-22 Type 2 diabetes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18675616 chr4:1962842 WHSC1 -0.4 -6.05 -0.35 4.94e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4555082 0.718 rs75139030 chr14:105710853 A/AG cg27165867 chr14:105738592 BRF1 -0.51 -5.42 -0.32 1.31e-7 Mean platelet volume;Platelet distribution width; CESC cis rs250677 0.522 rs10477400 chr5:148359598 T/C cg18129178 chr5:148520854 ABLIM3 0.47 5.16 0.3 4.85e-7 Breast cancer; CESC cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg08645402 chr16:4508243 NA 0.42 6.08 0.35 4.2e-9 Schizophrenia; CESC trans rs17307778 0.908 rs2404053 chr11:25357432 A/C cg22888484 chr20:37075185 SNHG11 -0.63 -6.17 -0.35 2.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs34638657 0.732 rs7206093 chr16:82201884 G/A cg09439754 chr16:82129088 HSD17B2 -0.35 -6.12 -0.35 3.29e-9 Lung adenocarcinoma; CESC cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg19193384 chr17:30244184 NA -0.68 -6.43 -0.37 5.9e-10 Hip circumference adjusted for BMI; CESC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg02398342 chr17:80708632 TBCD;FN3K 0.44 5.22 0.31 3.7e-7 Glycated hemoglobin levels; CESC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg03576123 chr11:487126 PTDSS2 -1.12 -11.21 -0.57 3.93e-24 Body mass index; CESC cis rs1215050 0.791 rs1215049 chr4:98848280 C/T cg05340658 chr4:99064831 C4orf37 0.52 6.87 0.39 4.52e-11 Waist-to-hip ratio adjusted for body mass index; CESC trans rs11098499 0.570 rs6832740 chr4:120546136 T/C cg25214090 chr10:38739885 LOC399744 0.63 8.89 0.48 9.62e-17 Corneal astigmatism; CESC cis rs1062177 1.000 rs17741826 chr5:151149262 C/T cg00977110 chr5:151150581 G3BP1 -0.64 -7.04 -0.4 1.6e-11 Preschool internalizing problems; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16835415 chr5:154136941 LARP1 -0.6 -6.47 -0.37 4.82e-10 Gut microbiome composition (summer); CESC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg11764359 chr7:65958608 NA -0.94 -15.58 -0.69 2.66e-39 Aortic root size; CESC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2011503 1.000 rs2916075 chr19:19530590 G/C cg11584989 chr19:19387371 SF4 0.63 7.29 0.41 3.54e-12 Bipolar disorder; CESC cis rs734999 0.588 rs3748818 chr1:2525660 G/A cg20673091 chr1:2541236 MMEL1 0.44 7.27 0.41 4.13e-12 Ulcerative colitis; CESC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 7.72 0.43 2.35e-13 Height; CESC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 5.86 0.34 1.39e-8 Bipolar disorder; CESC cis rs8020095 0.571 rs6573726 chr14:67324528 A/G cg19548862 chr14:67692701 FAM71D -0.49 -6.09 -0.35 3.85e-9 Depression (quantitative trait); CESC cis rs3740713 1.000 rs73438697 chr11:18462377 G/A cg23797887 chr11:18477753 LDHAL6A -0.52 -5.05 -0.3 8.21e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7772486 0.790 rs2254283 chr6:146204289 T/C cg05347473 chr6:146136440 FBXO30 0.56 7.25 0.41 4.46e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs314370 0.818 rs13245899 chr7:100497131 A/G cg10426581 chr7:100472382 SRRT 0.75 8.08 0.44 2.26e-14 Resting heart rate; CESC cis rs1185460 0.967 rs1786685 chr11:118938957 G/A cg23280166 chr11:118938394 VPS11 0.57 7.86 0.43 9.66e-14 Coronary artery disease; CESC cis rs4253772 0.591 rs73886791 chr22:46687212 A/G cg24881330 chr22:46731750 TRMU 0.94 10.35 0.54 2.62e-21 LDL cholesterol;Cholesterol, total; CESC cis rs637571 0.726 rs669371 chr11:65674153 G/T cg26695010 chr11:65641043 EFEMP2 0.51 6.27 0.36 1.46e-9 Eosinophil percentage of white cells; CESC cis rs2204008 0.837 rs11168334 chr12:37961768 A/G cg26384229 chr12:38710491 ALG10B 0.72 10.57 0.54 5.09e-22 Bladder cancer; CESC cis rs12048904 1.000 rs12048904 chr1:101331536 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.51 -6.61 -0.38 2.14e-10 Multiple sclerosis; CESC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7726839 0.540 rs74553517 chr5:665671 C/T cg09021430 chr5:549028 NA -0.42 -5.16 -0.3 4.75e-7 Obesity-related traits; CESC cis rs9640161 0.789 rs3735174 chr7:150020489 T/C cg21361702 chr7:150065534 REPIN1 0.5 5.79 0.34 2e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs75477785 0.590 rs1040426 chr1:210134631 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.91 6.32 0.36 1.09e-9 Cleft lip with or without cleft palate; CESC cis rs11626933 1.000 rs61989986 chr14:90739180 G/A cg14092571 chr14:90743983 NA -0.97 -15.2 -0.68 5.94e-38 Gut microbiota (bacterial taxa); CESC cis rs17854409 0.803 rs1048109 chr20:61472120 G/A cg07645718 chr20:61493192 TCFL5 0.79 5.2 0.3 3.98e-7 Obesity-related traits; CESC cis rs10276381 0.685 rs56398224 chr7:28205748 A/AT cg23620719 chr7:28220237 JAZF1 0.71 5.84 0.34 1.55e-8 Crohn's disease; CESC cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg16240275 chr20:61666158 NCRNA00029 0.5 8.95 0.48 6.42e-17 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18487508 chr19:39926862 RPS16 0.56 6.55 0.37 2.98e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10717766 chr19:5134118 KDM4B -0.58 -6.71 -0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs992157 0.710 rs12694432 chr2:219082330 A/G cg00012203 chr2:219082015 ARPC2 0.85 12.32 0.6 7.16e-28 Colorectal cancer; CESC cis rs250677 0.687 rs171636 chr5:148434545 G/A cg18129178 chr5:148520854 ABLIM3 -0.54 -5.36 -0.31 1.78e-7 Breast cancer; CESC cis rs2228479 0.850 rs11646766 chr16:89838578 A/T cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs4319547 0.695 rs12314643 chr12:122917423 C/T cg05707623 chr12:122985044 ZCCHC8 -0.49 -6.09 -0.35 3.91e-9 Body mass index; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg06795559 chr20:5931181 MCM8;TRMT6 -0.44 -6.47 -0.37 4.7e-10 Breast cancer; CESC cis rs7020830 0.898 rs308492 chr9:37298020 C/T cg14294708 chr9:37120828 ZCCHC7 1.22 23.27 0.82 5.31e-66 Schizophrenia; CESC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg09365446 chr1:150670422 GOLPH3L 0.38 5.14 0.3 5.31e-7 Melanoma; CESC cis rs7017914 0.967 rs56112621 chr8:71588394 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.09 -0.3 6.93e-7 Bone mineral density; CESC cis rs2251381 0.778 rs2471947 chr21:30534219 G/T cg08807101 chr21:30365312 RNF160 0.66 7.96 0.44 5.02e-14 Selective IgA deficiency; CESC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg22920501 chr2:26401640 FAM59B -0.67 -8.05 -0.44 2.86e-14 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16806347 chr16:70488291 FUK -0.5 -6.39 -0.37 7.3e-10 Asthma; CESC cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg04944784 chr2:26401820 FAM59B -0.91 -10.4 -0.54 1.82e-21 Gut microbiome composition (summer); CESC cis rs7539409 0.651 rs979757 chr1:84296605 T/C cg10977910 chr1:84465055 TTLL7 0.77 7.37 0.41 2.12e-12 Alzheimer's disease; CESC cis rs6912958 0.559 rs369674 chr6:88043402 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.43 -7.64 -0.42 4.03e-13 Monocyte percentage of white cells; CESC cis rs7264396 0.635 rs7263302 chr20:34545858 T/C cg17201900 chr20:34330562 RBM39 0.5 5.21 0.3 3.88e-7 Total cholesterol levels; CESC cis rs12142240 0.731 rs12385693 chr1:46818921 A/C cg00530320 chr1:46809349 NSUN4 0.53 6.76 0.38 8.67e-11 Menopause (age at onset); CESC cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.05 10.33 0.54 2.97e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6963495 0.818 rs56055535 chr7:105163574 C/A cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs1348850 0.789 rs2197611 chr2:178369036 G/C cg22681709 chr2:178499509 PDE11A -0.41 -5.89 -0.34 1.15e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2795502 0.873 rs2795527 chr10:43270240 T/C cg20628663 chr10:43360327 NA -0.7 -7.56 -0.42 6.52e-13 Blood protein levels; CESC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Depression; CESC trans rs8073060 0.614 rs225275 chr17:33972567 G/C cg19694781 chr19:47549865 TMEM160 -0.73 -7.32 -0.41 3.05e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs9303029 1.000 rs9898723 chr17:80439907 A/G cg04942655 chr17:80303572 NA -0.5 -5.24 -0.31 3.3e-7 Protein quantitative trait loci; CESC cis rs6998277 1.000 rs34217554 chr8:103646352 T/C cg10187029 chr8:103597600 NA 0.57 6.44 0.37 5.46e-10 Migraine; CESC cis rs4253772 0.513 rs6008700 chr22:46722560 C/T cg18190219 chr22:46762943 CELSR1 -0.44 -5.69 -0.33 3.37e-8 LDL cholesterol;Cholesterol, total; CESC cis rs634534 0.622 rs552130 chr11:65732800 T/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.81 0.39 6.63e-11 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs8070740 0.617 rs1058119 chr17:5323125 C/A cg25236894 chr17:5323110 RPAIN;NUP88 0.54 7.29 0.41 3.59e-12 Menopause (age at onset); CESC cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6430585 0.528 rs6743537 chr2:136702601 C/T cg07169764 chr2:136633963 MCM6 1.12 15.25 0.68 3.87e-38 Corneal structure; CESC trans rs9987128 0.649 rs7838112 chr8:2975517 A/G cg13438961 chr1:41250071 KCNQ4 -0.63 -6.71 -0.38 1.18e-10 Inflammatory skin disease; CESC cis rs9611565 0.921 rs5751080 chr22:41736267 A/G cg03806693 chr22:41940476 POLR3H -0.71 -8.53 -0.46 1.12e-15 Vitiligo; CESC cis rs11676348 0.712 rs11687434 chr2:218945143 A/G cg00012203 chr2:219082015 ARPC2 -0.43 -5.36 -0.31 1.77e-7 Ulcerative colitis; CESC cis rs1018836 0.545 rs7840203 chr8:91701223 A/G cg16814680 chr8:91681699 NA -0.96 -16.7 -0.72 2.78e-43 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs56235845 0.694 rs9313758 chr5:176773091 T/G cg16006841 chr5:176797999 RGS14 0.45 5.63 0.33 4.51e-8 Hemoglobin concentration;Hematocrit; CESC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -11.3 -0.57 1.93e-24 Alzheimer's disease; CESC cis rs13130787 0.802 rs280097 chr4:94937860 T/C cg11021082 chr4:95130006 SMARCAD1 0.4 5.52 0.32 8e-8 Colorectal cancer; CESC cis rs11203032 1.000 rs17117088 chr10:90961799 G/A cg16672925 chr10:90967113 CH25H 0.75 7.18 0.4 6.97e-12 Heart failure; CESC cis rs7508679 1.000 rs4804411 chr19:7222377 G/C cg09779027 chr19:7224513 INSR 0.53 8.56 0.47 9.04e-16 Hypothyroidism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19856334 chr2:172290437 DCAF17;METTL8 0.57 6.01 0.35 6.1e-9 Gut microbiome composition (summer); CESC trans rs11989744 0.500 rs7826966 chr8:23569106 G/T cg03492747 chr16:86543808 FOXF1 -0.84 -13.39 -0.64 1.42e-31 Waist-hip ratio; CESC cis rs57506017 0.540 rs7804736 chr7:12266867 G/T cg23422036 chr7:12250390 TMEM106B 0.38 5.14 0.3 5.24e-7 Neuroticism; CESC cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg25405998 chr7:65216604 CCT6P1 0.51 5.54 0.32 7.29e-8 Aortic root size; CESC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg07332563 chr6:291687 DUSP22 -0.69 -9.03 -0.49 3.7e-17 Menopause (age at onset); CESC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg08470875 chr2:26401718 FAM59B -0.46 -5.14 -0.3 5.45e-7 Gut microbiome composition (summer); CESC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg17372223 chr3:52568218 NT5DC2 0.44 6.41 0.37 6.63e-10 Bipolar disorder; CESC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg24733560 chr20:60626293 TAF4 0.49 7.08 0.4 1.3e-11 Body mass index; CESC cis rs17021463 0.673 rs4699459 chr4:95292702 G/A cg11021082 chr4:95130006 SMARCAD1 0.5 6.74 0.38 9.77e-11 Testicular germ cell tumor; CESC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg23161317 chr6:28129485 ZNF389 -0.54 -7.17 -0.4 7.39e-12 Depression; CESC cis rs2361718 0.967 rs12942941 chr17:78103013 C/T cg06718696 chr17:78121285 EIF4A3 0.46 6.17 0.35 2.54e-9 Yeast infection; CESC cis rs16973500 0.808 rs72801797 chr16:71975300 A/G cg00732059 chr16:71740210 PHLPP2 -0.49 -5.26 -0.31 2.96e-7 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs829661 0.532 rs11127276 chr2:30794215 C/T cg12454169 chr2:30669597 LCLAT1 -0.43 -5.3 -0.31 2.44e-7 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs9394438 0.628 rs804843 chr6:37545923 A/G cg00985040 chr6:37553208 NA -0.35 -5.84 -0.34 1.55e-8 IgG glycosylation; CESC cis rs367615 0.552 rs2963022 chr5:108727185 A/G cg17395555 chr5:108820864 NA -0.46 -7.56 -0.42 6.45e-13 Colorectal cancer (SNP x SNP interaction); CESC cis rs12325245 0.536 rs34129245 chr16:58588191 A/G cg01152986 chr16:58549298 SETD6 0.89 5.4 0.32 1.45e-7 Schizophrenia; CESC cis rs7903847 0.596 rs7922512 chr10:99155685 C/A cg20016023 chr10:99160130 RRP12 -0.3 -5.16 -0.3 4.77e-7 Granulocyte percentage of myeloid white cells; CESC cis rs919433 0.783 rs787979 chr2:198242868 A/T cg10820045 chr2:198174542 NA 0.4 5.79 0.34 1.96e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs10411161 0.702 rs10402630 chr19:52384570 G/A cg22319618 chr22:45562946 NUP50 -0.71 -7.04 -0.4 1.66e-11 Breast cancer; CESC cis rs4148883 0.689 rs1311621 chr4:100014018 T/C cg12011299 chr4:100065546 ADH4 0.67 10.12 0.53 1.43e-20 Alcohol dependence; CESC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs11785400 0.762 rs2280880 chr8:143721929 C/A cg24634471 chr8:143751801 JRK 0.43 5.38 0.31 1.64e-7 Schizophrenia; CESC cis rs1215050 0.765 rs783925 chr4:98969881 T/C cg05340658 chr4:99064831 C4orf37 -0.54 -7.32 -0.41 2.98e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9584850 0.507 rs59704350 chr13:99160430 T/A cg20750642 chr13:99100586 FARP1 -0.41 -5.71 -0.33 3e-8 Neuroticism; CESC cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg20503657 chr10:835505 NA 0.65 6.93 0.39 3.13e-11 Eosinophil percentage of granulocytes; CESC cis rs2235544 0.565 rs928443 chr1:54473516 C/T cg25741118 chr1:54482237 LDLRAD1 0.24 5.81 0.34 1.74e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs2046867 0.862 rs62252360 chr3:72838551 C/T cg25664220 chr3:72788482 NA -0.4 -5.92 -0.34 9.97e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05463257 chr3:182782445 MCCC1 -0.69 -8.36 -0.46 3.48e-15 Gut microbiome composition (summer); CESC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg13918804 chr1:2043761 PRKCZ 0.28 5.42 0.32 1.36e-7 Height; CESC cis rs7208859 0.623 rs11652533 chr17:29060601 A/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg20151795 chr6:28129481 ZNF389 0.41 5.25 0.31 3.07e-7 Depression; CESC cis rs34779708 0.966 rs12761675 chr10:35438337 C/T cg04310649 chr10:35416472 CREM 0.52 6.31 0.36 1.14e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg18758796 chr5:131593413 PDLIM4 0.45 6.62 0.38 1.99e-10 Breast cancer; CESC cis rs9547996 0.959 rs9548003 chr13:38233206 A/G cg17979426 chr13:38220150 TRPC4 -0.39 -5.4 -0.31 1.51e-7 Diastolic blood pressure; CESC cis rs11098499 0.754 rs12507565 chr4:120251121 G/A cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs10927875 1.000 rs12138117 chr1:16305279 T/C cg21385522 chr1:16154831 NA -0.77 -9.72 -0.51 2.64e-19 Dilated cardiomyopathy; CESC cis rs9733 0.715 rs12402006 chr1:150869829 G/A cg13175981 chr1:150552382 MCL1 0.47 6.14 0.35 3.05e-9 Tonsillectomy; CESC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg27170947 chr2:26402098 FAM59B 0.84 9.12 0.49 1.92e-17 Gut microbiome composition (summer); CESC cis rs7312774 0.748 rs12320535 chr12:107295813 T/C cg16260113 chr12:107380972 MTERFD3 0.61 5.7 0.33 3.21e-8 Severe influenza A (H1N1) infection; CESC cis rs7089973 0.604 rs7897937 chr10:116591318 A/G cg25233709 chr10:116636983 FAM160B1 0.38 5.9 0.34 1.12e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9549260 0.755 rs7328677 chr13:41229905 A/G cg21288729 chr13:41239152 FOXO1 0.65 8.51 0.46 1.27e-15 Red blood cell count; CESC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg02018176 chr4:1364513 KIAA1530 -0.56 -7.24 -0.41 4.85e-12 Longevity; CESC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg08888203 chr3:10149979 C3orf24 0.46 5.92 0.34 9.91e-9 Alzheimer's disease; CESC cis rs6496667 0.738 rs58438191 chr15:91045751 G/A cg13834112 chr15:90361639 NA 0.41 5.56 0.32 6.61e-8 Rheumatoid arthritis; CESC cis rs4975709 0.686 rs2307118 chr5:1881916 A/C cg15595755 chr5:1867978 NA 0.49 7.59 0.42 5.59e-13 Cardiovascular disease risk factors; CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg24503407 chr1:205819492 PM20D1 0.86 15.17 0.68 7.42e-38 Menarche (age at onset); CESC cis rs4237845 0.773 rs6650217 chr12:58289072 T/G cg02175503 chr12:58329896 NA 0.63 9.03 0.49 3.6e-17 Intelligence (multi-trait analysis); CESC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg23048001 chr7:2026167 MAD1L1 -0.46 -6.06 -0.35 4.76e-9 Bipolar disorder and schizophrenia; CESC cis rs965469 1.000 rs6051722 chr20:3274435 A/G cg25506879 chr20:3388711 C20orf194 -0.55 -5.96 -0.34 7.97e-9 IFN-related cytopenia; CESC cis rs11122272 0.735 rs11122281 chr1:231519842 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.75 -0.43 2.03e-13 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03686870 chr4:103682143 MANBA 0.66 7.49 0.42 9.97e-13 Gut microbiome composition (summer); CESC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg09877947 chr5:131593287 PDLIM4 0.51 6.8 0.39 6.73e-11 Acylcarnitine levels; CESC cis rs67311347 1.000 rs28434528 chr3:40484893 A/G cg09455208 chr3:40491958 NA 0.44 7.54 0.42 7.53e-13 Renal cell carcinoma; CESC cis rs6967414 0.786 rs7782227 chr7:6748594 T/C cg00387323 chr7:6746715 ZNF12 0.66 6.25 0.36 1.65e-9 Hematocrit;Hemoglobin concentration; CESC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.38 -0.31 1.67e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs7605827 0.930 rs4668451 chr2:15675285 C/T cg19274914 chr2:15703543 NA 0.38 6.8 0.39 7.12e-11 Educational attainment (years of education); CESC cis rs763121 0.853 rs1569716 chr22:38998519 C/A cg06022373 chr22:39101656 GTPBP1 0.91 16.13 0.7 3.08e-41 Menopause (age at onset); CESC cis rs2859741 0.608 rs534853 chr1:37474726 T/C cg09363841 chr1:37513479 NA -0.52 -7.16 -0.4 7.76e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC trans rs11264799 0.765 rs2152710 chr1:157626964 A/G cg22691776 chr3:15032403 NR2C2 0.34 6.22 0.36 1.93e-9 IgA nephropathy; CESC cis rs208515 0.556 rs1872309 chr6:66660432 A/C cg07460842 chr6:66804631 NA 0.73 8.52 0.46 1.25e-15 Exhaled nitric oxide levels; CESC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg09699651 chr6:150184138 LRP11 0.48 5.97 0.34 7.51e-9 Lung cancer; CESC trans rs208520 0.690 rs12201219 chr6:66748862 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.04 0.59 6.44e-27 Exhaled nitric oxide output; CESC cis rs79349575 0.783 rs318095 chr17:46974734 T/C cg16584676 chr17:46985605 UBE2Z 0.53 6.58 0.37 2.57e-10 Type 2 diabetes; CESC cis rs12824058 0.831 rs4759451 chr12:130812739 G/A cg24838063 chr12:130822603 PIWIL1 0.61 8.41 0.46 2.59e-15 Menopause (age at onset); CESC cis rs7762018 0.769 rs4716385 chr6:170127608 G/T cg05834625 chr6:170176447 C6orf70 0.56 6.06 0.35 4.76e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4766566 0.694 rs3847952 chr12:111746678 T/G cg10833066 chr12:111807467 FAM109A 0.32 5.13 0.3 5.64e-7 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; CESC cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg13175981 chr1:150552382 MCL1 0.71 10.58 0.55 4.63e-22 Tonsillectomy; CESC cis rs9815354 1.000 rs6789260 chr3:41776350 G/C cg03022575 chr3:42003672 ULK4 0.56 5.56 0.32 6.59e-8 Pulse pressure;Diastolic blood pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03535255 chr16:87492531 ZCCHC14 -0.35 -6.25 -0.36 1.64e-9 Gambling; CESC cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.82 0.34 1.74e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg02353165 chr6:42928485 GNMT 0.95 18.3 0.75 6.48e-49 Alzheimer's disease in APOE e4+ carriers; CESC trans rs6089829 0.889 rs6090206 chr20:61668363 G/A cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1.01e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs10129255 0.530 rs11624912 chr14:107129907 A/G cg07958169 chr14:107095056 NA -0.52 -8.31 -0.45 5.03e-15 Kawasaki disease; CESC cis rs6812193 0.518 rs7664593 chr4:77187916 C/T cg20311846 chr4:77356250 SHROOM3 0.27 5.14 0.3 5.43e-7 Parkinson's disease; CESC cis rs72781680 0.898 rs56216411 chr2:23934533 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.91 0.39 3.5e-11 Lymphocyte counts; CESC cis rs35110281 0.626 rs162367 chr21:44934857 A/G cg01579765 chr21:45077557 HSF2BP -0.48 -8.57 -0.47 8.58e-16 Mean corpuscular volume; CESC cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg02297831 chr4:17616191 MED28 0.6 7.69 0.43 2.89e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1371867 0.846 rs1788181 chr8:101334068 C/T cg11906718 chr8:101322791 RNF19A 0.46 5.91 0.34 1.03e-8 Atrioventricular conduction; CESC cis rs202629 1 rs202629 chr22:41849975 C/T cg17376030 chr22:41985996 PMM1 -0.56 -6.22 -0.36 1.92e-9 Cannabis dependence symptom count; CESC cis rs72781680 1.000 rs72796389 chr2:24171761 A/G cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.95 0.39 2.9100000000000002e-11 Electroencephalogram traits; CESC cis rs4460629 0.901 rs4745 chr1:155106227 A/T cg02153340 chr1:155202674 NA 0.35 5.08 0.3 7.12e-7 Serum magnesium levels; CESC cis rs1348850 0.750 rs12997716 chr2:178494629 G/A cg23306229 chr2:178417860 TTC30B 0.55 7.02 0.4 1.91e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.14 0.4 9.06e-12 Bipolar disorder; CESC cis rs12681366 0.734 rs10112606 chr8:95396066 T/C cg13257157 chr8:95487014 RAD54B 0.38 5.11 0.3 6.3e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18885107 chr1:46664327 POMGNT1 -0.4 -6.03 -0.35 5.6e-9 Gambling; CESC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg18876405 chr7:65276391 NA 0.53 7.39 0.41 1.87e-12 Aortic root size; CESC cis rs4689388 0.610 rs4328980 chr4:6281756 A/G cg00701064 chr4:6280414 WFS1 0.65 9.23 0.49 8.68e-18 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7927771 1.000 rs34910028 chr11:47758449 T/C cg18512352 chr11:47633146 NA -0.6 -9.5 -0.5 1.32e-18 Subjective well-being; CESC cis rs5758343 1 rs5758343 chr22:41816652 A/T cg06634786 chr22:41940651 POLR3H 0.73 7.3 0.41 3.43e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg02564969 chr6:151773285 C6orf211;RMND1 0.64 8.72 0.47 3.02e-16 Menarche (age at onset); CESC cis rs1707322 0.963 rs11211229 chr1:46400517 A/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1577917 0.917 rs35738006 chr6:86646309 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.02 -0.35 5.83e-9 Response to antipsychotic treatment; CESC cis rs722599 0.639 rs2193596 chr14:75234101 A/C cg08847533 chr14:75593920 NEK9 0.5 5.84 0.34 1.55e-8 IgG glycosylation; CESC cis rs8040855 0.627 rs12905036 chr15:85637788 C/T cg08123816 chr15:85640762 PDE8A -0.41 -6.02 -0.35 5.7e-9 Bulimia nervosa; CESC cis rs6460942 0.908 rs112897715 chr7:12241541 T/C cg06484146 chr7:12443880 VWDE -0.46 -5.04 -0.3 8.63e-7 Coronary artery disease; CESC cis rs7264396 0.676 rs6058380 chr20:34552900 T/G cg17201900 chr20:34330562 RBM39 0.49 5.11 0.3 6.08e-7 Total cholesterol levels; CESC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg10351095 chr21:47802916 PCNT -0.56 -7.82 -0.43 1.26e-13 Testicular germ cell tumor; CESC cis rs4909189 1.000 rs4909189 chr7:158136986 A/T cg06219351 chr7:158114137 PTPRN2 0.61 8.54 0.46 1.06e-15 Response to amphetamines; CESC cis rs2857078 0.732 rs9893756 chr17:42321109 T/C cg08499158 chr17:42289980 UBTF 0.48 5.88 0.34 1.23e-8 Red cell distribution width;Reticulocyte count; CESC cis rs80130819 0.688 rs4760692 chr12:48587549 T/C cg05342945 chr12:48394962 COL2A1 -0.52 -6.07 -0.35 4.5e-9 Prostate cancer; CESC cis rs6089584 0.566 rs6061401 chr20:60607482 G/A cg06108461 chr20:60628389 TAF4 -0.62 -8.19 -0.45 1.14e-14 Body mass index; CESC cis rs7917772 0.636 rs2486757 chr10:104535145 C/T cg04362960 chr10:104952993 NT5C2 -0.48 -5.38 -0.31 1.65e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg10074409 chr1:209979377 IRF6 0.4 5.29 0.31 2.52e-7 Cleft lip with or without cleft palate; CESC cis rs4803468 1.000 rs11883104 chr19:41923799 T/C cg09537434 chr19:41945824 ATP5SL -1.1 -20.39 -0.78 3.13e-56 Height; CESC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg18876405 chr7:65276391 NA -0.54 -7.4 -0.41 1.81e-12 Aortic root size; CESC cis rs1808579 0.935 rs12964689 chr18:21116998 A/G cg14672496 chr18:21087552 C18orf8 0.42 6.48 0.37 4.52e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg10691866 chr7:65817282 TPST1 0.31 5.34 0.31 1.95e-7 Aortic root size; CESC cis rs863345 0.604 rs12075228 chr1:158502256 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg07256732 chr16:621771 PIGQ -0.32 -5.62 -0.33 4.76e-8 Height; CESC cis rs7513165 0.935 rs12097666 chr1:204162212 A/G cg23788856 chr1:204159729 KISS1 -0.37 -5.08 -0.3 7.27e-7 Psychosis proneness (hypomanic personality scale);Psychosis proneness (hypomanic personality scale and perceptual aberration scale);Psychosis proneness (hypomanic personality scale and revised social anhedonia scale);Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale); CESC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg14703610 chr5:56206110 C5orf35 -0.48 -6.32 -0.36 1.09e-9 Breast cancer;Breast cancer (early onset); CESC cis rs6545883 0.801 rs778142 chr2:61681428 G/T cg15711740 chr2:61764176 XPO1 -0.41 -5.34 -0.31 2.04e-7 Tuberculosis; CESC cis rs11718455 0.883 rs6795366 chr3:44005735 C/T cg08738300 chr3:44038990 NA 0.44 5.86 0.34 1.35e-8 Coronary artery disease; CESC cis rs62432291 0.681 rs378547 chr6:159662525 A/G cg14500486 chr6:159655392 FNDC1 0.55 5.38 0.31 1.68e-7 Joint mobility (Beighton score); CESC cis rs9894429 0.809 rs9889642 chr17:79591762 T/C cg21984481 chr17:79567631 NPLOC4 -0.47 -7.63 -0.42 4.29e-13 Eye color traits; CESC trans rs79243044 0.786 rs16932549 chr11:5560909 C/T cg13404532 chr3:128483276 RAB7A -0.48 -6.01 -0.35 6.09e-9 QRS duration in Tripanosoma cruzi seropositivity; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg25932386 chr2:37459326 CEBPZ;C2orf56 -0.46 -6.02 -0.35 5.78e-9 Asthma; CESC cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg15744005 chr10:104629667 AS3MT -0.34 -5.32 -0.31 2.26e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg12463550 chr7:65579703 CRCP -0.54 -6.65 -0.38 1.65e-10 Aortic root size; CESC cis rs7726839 0.794 rs10474792 chr5:600058 G/A cg09021430 chr5:549028 NA -0.44 -6.23 -0.36 1.84e-9 Obesity-related traits; CESC cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg07636037 chr3:49044803 WDR6 1.03 18.76 0.76 1.49e-50 Parkinson's disease; CESC cis rs8072100 0.713 rs4968318 chr17:45451894 G/A cg08085267 chr17:45401833 C17orf57 -0.51 -6.35 -0.36 9.29e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6987853 0.563 rs2974312 chr8:42455846 C/T cg09913449 chr8:42400586 C8orf40 0.33 5.17 0.3 4.66e-7 Mean corpuscular hemoglobin concentration; CESC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg08888203 chr3:10149979 C3orf24 0.47 6.03 0.35 5.45e-9 Alzheimer's disease; CESC cis rs11792861 0.816 rs11790105 chr9:111731785 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 6.5 0.37 3.86e-10 Menarche (age at onset); CESC cis rs56104184 0.775 rs73061699 chr19:49400511 T/C cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.0 -0.4 2.05e-11 Neuroticism; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg17883223 chr7:56854974 NA -0.38 -6.17 -0.35 2.51e-9 Thyroid stimulating hormone; CESC cis rs2832191 0.692 rs8134627 chr21:30349069 C/T cg24692254 chr21:30365293 RNF160 -0.97 -17.29 -0.73 2.35e-45 Dental caries; CESC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.34 -5.78 -0.33 2.11e-8 Bipolar disorder; CESC cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg24110177 chr3:50126178 RBM5 -0.53 -7.35 -0.41 2.48e-12 Intelligence (multi-trait analysis); CESC cis rs12681366 0.663 rs6980687 chr8:95481913 A/G cg13257157 chr8:95487014 RAD54B 0.37 5.03 0.3 8.9e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14770633 chr2:27851514 GPN1;CCDC121 0.59 7.23 0.41 5.12e-12 Gut microbiome composition (summer); CESC cis rs9905704 0.647 rs10221208 chr17:57047885 T/C cg12560992 chr17:57184187 TRIM37 0.62 7.89 0.44 7.8e-14 Testicular germ cell tumor; CESC cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg10556349 chr10:835070 NA -0.59 -5.7 -0.33 3.11e-8 Eosinophil percentage of granulocytes; CESC trans rs1814175 0.817 rs7950856 chr11:49976394 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -21.34 -0.8 1.71e-59 Height; CESC cis rs208515 0.525 rs10498841 chr6:66663706 C/T cg07460842 chr6:66804631 NA 0.83 10.33 0.54 3.09e-21 Exhaled nitric oxide levels; CESC cis rs2795502 0.872 rs2744062 chr10:43254789 T/A cg20628663 chr10:43360327 NA -0.7 -7.32 -0.41 2.96e-12 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11543725 chr11:10329292 NA 0.53 6.41 0.37 6.45e-10 Gut microbiome composition (summer); CESC cis rs7107174 0.901 rs2912 chr11:77926292 G/A cg02023728 chr11:77925099 USP35 0.47 5.97 0.34 7.71e-9 Testicular germ cell tumor; CESC trans rs4689592 0.503 rs10516184 chr4:7060959 C/T cg07817883 chr1:32538562 TMEM39B -0.64 -6.42 -0.37 6.17e-10 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12538369 chr19:40932019 SERTAD1 -0.63 -7.57 -0.42 6.39e-13 Gut microbiome composition (summer); CESC cis rs3857536 0.740 rs6455080 chr6:66887413 T/A cg07460842 chr6:66804631 NA -0.42 -5.39 -0.31 1.53e-7 Blood trace element (Cu levels); CESC cis rs7429990 0.932 rs7620736 chr3:48109969 C/T cg11946769 chr3:48343235 NME6 -0.45 -5.53 -0.32 7.61e-8 Educational attainment (years of education); CESC cis rs4595586 0.525 rs7136425 chr12:39376005 C/A cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs6088590 1.000 rs10048849 chr20:33419680 C/T cg24642439 chr20:33292090 TP53INP2 0.84 11.75 0.59 6.21e-26 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22529720 chr7:139044624 LUC7L2 0.57 6.38 0.36 7.84e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08262876 chr10:102757026 LZTS2 -0.7 -8.3 -0.45 5.22e-15 Gut microbiome composition (summer); CESC trans rs10241579 0.803 rs10254706 chr7:52769619 A/C cg18715243 chr8:37658755 GPR124 -0.48 -6.12 -0.35 3.35e-9 Inhibitory control; CESC cis rs10788264 0.504 rs10749451 chr10:124028040 C/T cg09507567 chr10:124027408 NA 0.39 5.41 0.32 1.42e-7 Total body bone mineral density; CESC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg18876405 chr7:65276391 NA -0.5 -6.92 -0.39 3.36e-11 Aortic root size; CESC trans rs11722228 0.508 rs73212864 chr4:10104191 G/A cg26043149 chr18:55253948 FECH 0.92 10.72 0.55 1.62e-22 Gout;Urate levels;Serum uric acid levels; CESC cis rs6484504 0.576 rs158144 chr11:31211795 A/C cg14844989 chr11:31128820 NA -0.41 -5.88 -0.34 1.22e-8 Red blood cell count; CESC cis rs1048238 0.525 rs848214 chr1:16265422 A/G cg21385522 chr1:16154831 NA -0.43 -5.48 -0.32 9.88e-8 Systolic blood pressure; CESC cis rs7084402 0.967 rs1658457 chr10:60302716 T/C cg07615347 chr10:60278583 BICC1 0.6 9.43 0.5 2.17e-18 Refractive error; CESC cis rs6570726 0.875 rs12524077 chr6:145866333 G/C cg05347473 chr6:146136440 FBXO30 0.48 6.45 0.37 5.27e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs870825 0.616 rs28660669 chr4:185623312 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs72777070 0.895 rs12615784 chr2:9789403 A/G cg14973360 chr2:9800511 NA -0.49 -5.15 -0.3 5.19e-7 Platelet-derived growth factor BB levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00526316 chr1:151043472 GABPB2 -0.42 -6.32 -0.36 1.12e-9 Gambling; CESC cis rs7511006 1.000 rs7364173 chr22:50681029 C/T cg16473166 chr22:50639996 SELO -0.5 -6.27 -0.36 1.43e-9 Obesity-related traits; CESC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg17376030 chr22:41985996 PMM1 0.68 7.25 0.41 4.6e-12 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20856064 chr3:49027210 P4HTM 0.62 6.72 0.38 1.09e-10 Gut microbiome composition (summer); CESC cis rs684232 0.666 rs1227028 chr17:573298 G/A cg15660573 chr17:549704 VPS53 -0.64 -8.78 -0.47 2.09e-16 Prostate cancer; CESC cis rs9811920 0.809 rs793443 chr3:99573547 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.44 -7.39 -0.41 1.95e-12 Axial length; CESC cis rs1348850 0.526 rs6723014 chr2:178410586 G/A cg23306229 chr2:178417860 TTC30B 0.85 7.9 0.44 7.47e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9660992 0.649 rs72745216 chr1:205261016 G/A cg00857998 chr1:205179979 DSTYK 0.49 5.51 0.32 8.52e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg09742643 chr7:157958748 PTPRN2 0.38 6.56 0.37 2.79e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs854765 0.583 rs4413022 chr17:17858280 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.14 0.4 8.73e-12 Total body bone mineral density; CESC cis rs9457247 1.000 rs932644 chr6:167404187 A/C cg25258033 chr6:167368657 RNASET2 0.39 5.88 0.34 1.26e-8 Crohn's disease; CESC cis rs763121 0.853 rs138704 chr22:39133410 A/G cg06022373 chr22:39101656 GTPBP1 0.93 17.3 0.73 2.21e-45 Menopause (age at onset); CESC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg05552183 chr6:42928497 GNMT 0.85 14.72 0.67 3.1e-36 Alzheimer's disease in APOE e4+ carriers; CESC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg02951883 chr7:2050386 MAD1L1 -0.44 -5.62 -0.33 4.93e-8 Bipolar disorder and schizophrenia; CESC cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg16447950 chr5:562315 NA -0.71 -7.83 -0.43 1.2e-13 Lung disease severity in cystic fibrosis; CESC cis rs6088580 0.634 rs4911421 chr20:32998948 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -6.99 -0.39 2.17e-11 Glomerular filtration rate (creatinine); CESC cis rs2635047 0.967 rs2684820 chr18:44664304 G/A cg19077165 chr18:44547161 KATNAL2 -0.43 -5.85 -0.34 1.47e-8 Educational attainment; CESC cis rs12200560 0.505 rs4839848 chr6:97076577 G/A cg06623918 chr6:96969491 KIAA0776 0.51 6.46 0.37 5.04e-10 Coronary heart disease; CESC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg22800045 chr5:56110881 MAP3K1 0.5 5.99 0.35 6.89e-9 Coronary artery disease; CESC cis rs11122272 0.735 rs2790877 chr1:231535427 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.7 -0.43 2.8e-13 Hemoglobin concentration; CESC trans rs637571 0.522 rs12792888 chr11:65761446 C/T cg17712092 chr4:129076599 LARP1B 0.74 10.21 0.53 7.53e-21 Eosinophil percentage of white cells; CESC cis rs1878931 0.501 rs9302871 chr16:3415512 T/C cg05754148 chr16:3507555 NAT15 -0.39 -5.24 -0.31 3.25e-7 Body mass index (adult); CESC cis rs9768139 0.733 rs34173461 chr7:158122175 C/G cg24154853 chr7:158122151 PTPRN2 0.4 6.24 0.36 1.72e-9 Calcium levels; CESC cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg27286337 chr10:134555280 INPP5A 0.64 7.64 0.42 4.1e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs10870270 0.956 rs7915388 chr10:133734972 G/A cg26149184 chr10:133730230 NA 0.38 5.15 0.3 5.07e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg02725872 chr8:58115012 NA -0.45 -6.84 -0.39 5.31e-11 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02458088 chr16:77228411 MON1B -0.61 -6.87 -0.39 4.5e-11 Gut microbiome composition (summer); CESC cis rs8077889 0.917 rs4793038 chr17:41916761 A/T cg26893861 chr17:41843967 DUSP3 0.72 9.71 0.51 2.94e-19 Triglycerides; CESC cis rs10492096 0.783 rs11064220 chr12:6592574 C/T cg13857086 chr12:6580257 VAMP1 0.52 5.2 0.3 4.07e-7 Hip geometry; CESC cis rs73206853 0.698 rs73191806 chr12:110899913 A/G cg12870014 chr12:110450643 ANKRD13A 0.63 5.18 0.3 4.34e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7264396 1.000 rs224437 chr20:34154371 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -6.44 -0.37 5.45e-10 Total cholesterol levels; CESC cis rs6088590 0.542 rs6059956 chr20:33220070 A/G cg06115741 chr20:33292138 TP53INP2 0.53 6.71 0.38 1.17e-10 Coronary artery disease; CESC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg12311346 chr5:56204834 C5orf35 -0.86 -10.64 -0.55 2.93e-22 Initial pursuit acceleration; CESC trans rs6715284 0.892 rs72937112 chr2:202228108 T/C cg00425217 chr19:13205470 NFIX -0.61 -6.07 -0.35 4.33e-9 Rheumatoid arthritis; CESC cis rs7100689 0.725 rs10736340 chr10:82061071 C/T cg09936400 chr10:82049201 MAT1A 0.37 5.3 0.31 2.41e-7 Post bronchodilator FEV1; CESC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg19163074 chr7:65112434 INTS4L2 0.41 5.18 0.3 4.32e-7 Aortic root size; CESC cis rs7772486 0.840 rs2777478 chr6:146309117 T/C cg05347473 chr6:146136440 FBXO30 0.56 7.37 0.41 2.14e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2832191 0.791 rs28633762 chr21:30500070 C/T cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.5e-20 Dental caries; CESC cis rs5750830 0.594 rs6001568 chr22:39775786 G/A cg11247378 chr22:39784982 NA -0.6 -8.83 -0.48 1.42e-16 Intelligence (multi-trait analysis); CESC cis rs2777491 0.915 rs28583065 chr15:41608470 T/C cg18705301 chr15:41695430 NDUFAF1 -0.6 -8.98 -0.48 5.23e-17 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04015759 chr2:27718181 FNDC4 0.52 6.78 0.38 7.8e-11 Gut microbiome composition (summer); CESC cis rs8014204 0.762 rs10148293 chr14:75296831 C/T cg08847533 chr14:75593920 NEK9 -0.43 -5.66 -0.33 3.84e-8 Caffeine consumption; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14965979 chr2:44588995 PREPL;C2orf34 0.61 6.69 0.38 1.36e-10 Gut microbiome composition (summer); CESC cis rs796364 0.951 rs12620298 chr2:201047184 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -6.35 -0.36 9.11e-10 Schizophrenia; CESC cis rs9487051 0.676 rs6903107 chr6:109597711 A/G cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC cis rs2236918 0.901 rs1776132 chr1:242024473 C/G cg17736920 chr1:242011382 EXO1 0.68 8.76 0.47 2.39e-16 Menopause (age at onset); CESC cis rs4654899 0.758 rs17453044 chr1:21517361 A/G cg05370193 chr1:21551575 ECE1 0.4 6.12 0.35 3.27e-9 Superior frontal gyrus grey matter volume; CESC trans rs1814175 0.645 rs10128731 chr11:50023554 G/T cg11707556 chr5:10655725 ANKRD33B -0.41 -6.01 -0.35 6.08e-9 Height; CESC cis rs8133932 0.654 rs420386 chr21:47364816 G/A cg14185626 chr21:47401492 COL6A1 -0.48 -5.34 -0.31 1.98e-7 Schizophrenia; CESC trans rs877282 1.000 rs12779159 chr10:772143 T/C cg22713356 chr15:30763199 NA 1.25 12.53 0.61 1.33e-28 Uric acid levels; CESC cis rs644799 1.000 rs632388 chr11:95563775 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.57e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs3780486 0.846 rs6476399 chr9:33123013 A/G cg04842962 chr6:43655489 MRPS18A 1.0 19.44 0.77 6.43e-53 IgG glycosylation; CESC cis rs72627123 0.656 rs17096949 chr14:74602360 A/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.03 0.3 8.99e-7 Morning vs. evening chronotype; CESC cis rs4919087 0.962 rs10748691 chr10:98983955 C/T cg25902810 chr10:99078978 FRAT1 0.71 10.14 0.53 1.27e-20 Monocyte count; CESC cis rs3733585 0.673 rs4697914 chr4:9952266 G/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs965469 0.779 rs2236088 chr20:3256342 T/C cg25506879 chr20:3388711 C20orf194 -0.49 -5.36 -0.31 1.8e-7 IFN-related cytopenia; CESC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs208520 1.000 rs208529 chr6:66957549 T/C cg07460842 chr6:66804631 NA -0.8 -9.14 -0.49 1.64e-17 Exhaled nitric oxide output; CESC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg05368731 chr17:41323189 NBR1 0.76 10.35 0.54 2.73e-21 Menopause (age at onset); CESC cis rs116095464 0.614 rs10061564 chr5:271329 T/C cg20965017 chr5:231967 SDHA -0.47 -5.3 -0.31 2.46e-7 Breast cancer; CESC cis rs5769765 0.671 rs138844 chr22:50184484 T/G cg02269571 chr22:50332266 NA -0.49 -6.24 -0.36 1.68e-9 Schizophrenia; CESC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg25405998 chr7:65216604 CCT6P1 0.53 6.68 0.38 1.37e-10 Calcium levels; CESC cis rs6541297 0.941 rs6693579 chr1:230282707 T/C cg20703242 chr1:230279135 GALNT2 0.75 8.14 0.45 1.57e-14 Coronary artery disease; CESC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg03388025 chr16:89894329 SPIRE2 0.35 6.19 0.36 2.29e-9 Vitiligo; CESC cis rs6754311 0.731 rs4954490 chr2:136608231 G/A cg07169764 chr2:136633963 MCM6 -0.69 -8.48 -0.46 1.59e-15 Mosquito bite size; CESC cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.93 0.34 9.53e-9 Tonsillectomy; CESC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg22535103 chr8:58192502 C8orf71 -0.89 -9.47 -0.5 1.64e-18 Developmental language disorder (linguistic errors); CESC cis rs9549367 0.789 rs9549698 chr13:113877701 A/G cg00898013 chr13:113819073 PROZ -0.48 -7.12 -0.4 1.04e-11 Platelet distribution width; CESC cis rs7523050 0.643 rs34572569 chr1:109401856 A/T cg08274380 chr1:109419600 GPSM2 0.86 5.69 0.33 3.36e-8 Fat distribution (HIV); CESC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg16680214 chr1:154839983 KCNN3 -0.44 -6.81 -0.39 6.66e-11 Prostate cancer; CESC cis rs5167 0.677 rs2238682 chr19:45458593 C/T cg13119609 chr19:45449297 APOC2 0.38 5.35 0.31 1.89e-7 Blood protein levels; CESC cis rs208520 0.661 rs7747492 chr6:66857788 A/T cg07460842 chr6:66804631 NA -1.01 -13.48 -0.64 6.84e-32 Exhaled nitric oxide output; CESC cis rs910316 0.737 rs175071 chr14:75498177 A/G cg16144293 chr14:75469539 EIF2B2 0.39 5.27 0.31 2.78e-7 Height; CESC cis rs9309473 0.748 rs2421552 chr2:73758803 C/T cg20560298 chr2:73613845 ALMS1 -0.51 -6.53 -0.37 3.43e-10 Metabolite levels; CESC cis rs7527798 0.592 rs11118278 chr1:207831357 C/G cg21110645 chr1:207815933 NA -0.32 -5.41 -0.32 1.38e-7 Erythrocyte sedimentation rate; CESC cis rs11122272 0.668 rs2790874 chr1:231537988 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.47 -0.42 1.14e-12 Hemoglobin concentration; CESC cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.25 -0.31 3.13e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg19717773 chr7:2847554 GNA12 -0.52 -7.61 -0.42 4.94e-13 Height; CESC cis rs6933660 0.646 rs6915598 chr6:151778664 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.68 7.25 0.41 4.66e-12 Menarche (age at onset); CESC cis rs7208859 0.623 rs34756112 chr17:29113016 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg05564831 chr3:52568323 NT5DC2 0.45 6.8 0.39 6.82e-11 Bipolar disorder; CESC trans rs208520 0.690 rs207108 chr6:66794096 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.83 -0.62 1.2e-29 Exhaled nitric oxide output; CESC cis rs4474465 0.920 rs7947852 chr11:78198030 T/C cg27205649 chr11:78285834 NARS2 -0.43 -5.54 -0.32 7.3900000000000007e-08 Alzheimer's disease (survival time); CESC trans rs78049276 0.736 rs72957606 chr4:148400011 A/G cg13149281 chr14:23389818 RBM23;PRMT5 -0.69 -7.51 -0.42 8.92e-13 Pulse pressure; CESC cis rs10791097 0.694 rs3190331 chr11:130748131 C/T cg09137382 chr11:130731461 NA -0.37 -5.56 -0.32 6.53e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1953600 0.668 rs3122586 chr10:81950326 C/T cg00277334 chr10:82204260 NA 0.54 7.95 0.44 5.46e-14 Sarcoidosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10777407 chr15:23311741 HERC2P2 -0.5 -6.46 -0.37 4.92e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.686 rs7744014 chr6:146123818 G/A cg23711669 chr6:146136114 FBXO30 0.87 13.02 0.62 2.64e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg06212747 chr3:49208901 KLHDC8B 0.65 9.43 0.5 2.14e-18 Menarche (age at onset); CESC cis rs6121246 0.529 rs750144 chr20:30179027 C/T cg13852791 chr20:30311386 BCL2L1 -0.58 -5.66 -0.33 3.9e-8 Mean corpuscular hemoglobin; CESC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg18876405 chr7:65276391 NA -0.45 -6.18 -0.35 2.43e-9 Aortic root size; CESC cis rs6674970 0.627 rs2864700 chr1:151028929 C/T cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.41 -5.39 -0.31 1.59e-7 Childhood ear infection; CESC cis rs55894132 1 rs55894132 chr14:23408837 C/G cg01529538 chr14:23388837 RBM23 0.46 6.04 0.35 5.2e-9 Intelligence (multi-trait analysis); CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg04025307 chr7:1156635 C7orf50 0.5 8.5 0.46 1.36e-15 Longevity;Endometriosis; CESC cis rs7223966 1.000 rs11658329 chr17:61763031 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.56 -7.22 -0.41 5.34e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs911555 0.511 rs8007489 chr14:104054572 A/G cg24130564 chr14:104152367 KLC1 0.69 11.13 0.56 7.58e-24 Intelligence (multi-trait analysis); CESC trans rs6600671 1.000 rs11249351 chr1:121171942 G/A cg17023122 chr1:144479586 NA 0.44 6.17 0.35 2.6e-9 Hip geometry; CESC cis rs12682352 0.652 rs1567398 chr8:8726804 A/C cg06636001 chr8:8085503 FLJ10661 -0.39 -5.04 -0.3 8.72e-7 Neuroticism; CESC cis rs11871801 0.517 rs35635959 chr17:40772288 T/C cg16308533 chr17:40838983 CNTNAP1 0.39 5.12 0.3 5.95e-7 Crohn's disease; CESC cis rs155076 1.000 rs598754 chr13:21845010 C/A cg11317459 chr13:21872234 NA -1.01 -11.12 -0.56 7.88e-24 White matter hyperintensity burden; CESC cis rs765787 0.530 rs2899379 chr15:45534799 C/T cg24006582 chr15:45444508 DUOX1 0.58 6.97 0.39 2.5e-11 Uric acid levels; CESC cis rs11690935 0.959 rs6745143 chr2:172650382 G/A cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.76 -0.67 2.21e-36 Schizophrenia; CESC cis rs6061231 0.631 rs2427318 chr20:60975727 G/T cg22633769 chr20:60982531 CABLES2 0.56 7.21 0.4 5.96e-12 Colorectal cancer; CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg18765753 chr7:1198926 ZFAND2A -0.4 -5.04 -0.3 8.66e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9399401 0.667 rs1329707 chr6:142724439 T/C cg03128060 chr6:142623767 GPR126 0.39 6.58 0.37 2.57e-10 Chronic obstructive pulmonary disease; CESC cis rs3782774 0.564 rs12580347 chr12:3388932 T/C cg17043230 chr12:3427729 NA -0.29 -5.07 -0.3 7.47e-7 Coronary artery disease; CESC cis rs3796352 1.000 rs71301808 chr3:53085577 C/G cg07884673 chr3:53033167 SFMBT1 0.65 5.63 0.33 4.49e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs4953318 0.577 rs67087783 chr2:46363544 C/T cg12428440 chr2:46370979 PRKCE 0.48 6.02 0.35 5.94e-9 Red blood cell count;Hematocrit;Red blood cell traits; CESC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs9894429 0.608 rs8477 chr17:79618059 C/T cg13777783 chr17:79615861 NA -0.33 -5.48 -0.32 9.69e-8 Eye color traits; CESC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.84 0.55 6.79e-23 Alzheimer's disease; CESC cis rs763121 0.853 rs6001184 chr22:39052116 C/T cg06022373 chr22:39101656 GTPBP1 0.88 13.91 0.65 2.06e-33 Menopause (age at onset); CESC cis rs4566357 0.615 rs2272202 chr2:227914625 C/T cg11843606 chr2:227700838 RHBDD1 0.43 5.81 0.34 1.82e-8 Coronary artery disease; CESC cis rs10887741 0.546 rs7903516 chr10:89441102 T/C cg13926569 chr10:89418898 PAPSS2 0.5 8.01 0.44 3.6e-14 Exercise (leisure time); CESC cis rs7086627 0.515 rs10887896 chr10:82210144 A/C cg00277334 chr10:82204260 NA -0.9 -15.67 -0.69 1.3e-39 Post bronchodilator FEV1; CESC cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg23711669 chr6:146136114 FBXO30 1.01 15.56 0.69 3.07e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg02018176 chr4:1364513 KIAA1530 0.6 7.43 0.42 1.47e-12 Longevity; CESC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.34 0.81 6.93e-63 Prudent dietary pattern; CESC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg03806693 chr22:41940476 POLR3H 1.16 13.59 0.64 2.85e-32 Vitiligo; CESC cis rs7084402 0.967 rs1649022 chr10:60285867 A/G cg07615347 chr10:60278583 BICC1 0.59 9.44 0.5 2.04e-18 Refractive error; CESC cis rs1046896 0.562 rs9912684 chr17:80873067 C/T cg19046167 chr17:80928561 B3GNTL1 0.49 6.1 0.35 3.66e-9 Glycated hemoglobin levels; CESC cis rs9402673 0.517 rs978036 chr6:135342903 C/T cg22676075 chr6:135203613 NA 0.51 7.36 0.41 2.34e-12 Reticulocyte count;High light scatter reticulocyte count; CESC cis rs7772486 0.875 rs1331640 chr6:146427250 G/A cg23711669 chr6:146136114 FBXO30 0.86 12.46 0.61 2.39e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.82 -12.1 -0.6 3.83e-27 Systemic lupus erythematosus; CESC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg08470875 chr2:26401718 FAM59B -0.76 -8.63 -0.47 5.63e-16 Gut microbiome composition (summer); CESC cis rs7587476 0.784 rs13008641 chr2:215698033 T/C cg04004882 chr2:215674386 BARD1 0.5 5.42 0.32 1.36e-7 Neuroblastoma; CESC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg22535103 chr8:58192502 C8orf71 -0.84 -9.44 -0.5 2.04e-18 Developmental language disorder (linguistic errors); CESC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg18350739 chr11:68623251 NA -0.48 -7.33 -0.41 2.84e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg11301795 chr4:187892539 NA -0.81 -14.18 -0.66 2.37e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs7296418 0.961 rs4275659 chr12:123447928 C/T cg00376283 chr12:123451042 ABCB9 -0.72 -10.34 -0.54 2.83e-21 Platelet count; CESC cis rs4555082 0.834 rs11622165 chr14:105759761 C/A cg13114125 chr14:105738426 BRF1 -0.88 -10.43 -0.54 1.41e-21 Mean platelet volume;Platelet distribution width; CESC cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg17366294 chr4:99064904 C4orf37 0.62 8.84 0.48 1.41e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.515 rs13434650 chr4:98889886 A/G cg17366294 chr4:99064904 C4orf37 0.51 6.37 0.36 8.15e-10 Colonoscopy-negative controls vs population controls; CESC cis rs9814567 1.000 rs7648990 chr3:134244390 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.15 -0.35 2.87e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs360798 0.512 rs4671050 chr2:62988169 G/T cg17519650 chr2:63277830 OTX1 -0.59 -7.62 -0.42 4.57e-13 Coronary artery disease; CESC cis rs11190604 1.000 rs7905961 chr10:102297391 G/C cg07080220 chr10:102295463 HIF1AN 0.6 5.82 0.34 1.72e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs12220238 1.000 rs12252705 chr10:75984863 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.0 0.35 6.42e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs727505 1.000 rs720613 chr7:124452670 C/T cg23710748 chr7:124431027 NA -0.4 -6.42 -0.37 6.38e-10 Lewy body disease; CESC cis rs7208859 0.673 rs1347359 chr17:28914529 T/C cg04154034 chr17:28927549 LRRC37B2 0.66 5.83 0.34 1.63e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7178572 0.568 rs11853460 chr15:77515319 C/T cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC cis rs1801251 1.000 rs3816334 chr2:233708806 A/G cg08000102 chr2:233561755 GIGYF2 -0.7 -10.07 -0.53 2.08e-20 Coronary artery disease; CESC cis rs6088580 0.542 rs6059882 chr20:33090167 T/C cg24642439 chr20:33292090 TP53INP2 0.5 6.55 0.37 2.92e-10 Glomerular filtration rate (creatinine); CESC cis rs11098499 0.604 rs2389886 chr4:120570422 C/T cg09307838 chr4:120376055 NA 0.75 9.44 0.5 1.97e-18 Corneal astigmatism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09391093 chr10:38265555 ZNF25 0.51 6.86 0.39 4.97e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg05564831 chr3:52568323 NT5DC2 0.45 6.88 0.39 4.28e-11 Bipolar disorder; CESC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg24101359 chr6:42928495 GNMT -0.6 -9.12 -0.49 1.92e-17 Alzheimer's disease in APOE e4+ carriers; CESC cis rs854765 0.547 rs2955384 chr17:17939573 C/T cg26588076 chr17:17741631 SREBF1 -0.32 -5.09 -0.3 6.95e-7 Total body bone mineral density; CESC cis rs6460942 0.915 rs62448602 chr7:12457145 T/G cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18598152 chr14:24020957 NA -0.57 -6.64 -0.38 1.81e-10 Gut microbiome composition (summer); CESC cis rs4253772 0.591 rs6519993 chr22:46656479 A/G cg24881330 chr22:46731750 TRMU 0.89 9.99 0.52 3.68e-20 LDL cholesterol;Cholesterol, total; CESC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg12311346 chr5:56204834 C5orf35 -0.73 -8.74 -0.47 2.69e-16 Initial pursuit acceleration; CESC cis rs2932538 0.922 rs12138335 chr1:113122760 T/C cg22162597 chr1:113214053 CAPZA1 0.6 7.33 0.41 2.75e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs9303280 0.806 rs36038753 chr17:38035370 G/T cg20243544 chr17:37824526 PNMT 0.5 6.54 0.37 3.21e-10 Self-reported allergy; CESC cis rs4727027 0.899 rs7791496 chr7:148863674 C/G cg23158103 chr7:148848205 ZNF398 -0.42 -6.88 -0.39 4.26e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7084402 0.967 rs1649085 chr10:60292042 T/C cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27514509 chr10:100167426 PYROXD2 0.44 6.27 0.36 1.43e-9 Fibrinogen levels; CESC cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg20607287 chr7:12443886 VWDE -0.81 -9.28 -0.5 6.09e-18 Coronary artery disease; CESC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg00750074 chr16:89608354 SPG7 -0.39 -5.49 -0.32 9.54e-8 Multiple myeloma (IgH translocation); CESC cis rs7122539 0.839 rs6591223 chr11:66609289 C/T cg24851651 chr11:66362959 CCS 0.38 5.24 0.31 3.36e-7 HIV-1 susceptibility; CESC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg18301423 chr5:131593218 PDLIM4 0.38 5.5 0.32 8.83e-8 Acylcarnitine levels; CESC trans rs13098911 0.540 rs34442130 chr3:46024529 T/A cg10236987 chr1:228114221 WNT9A 0.6 6.17 0.35 2.61e-9 Celiac disease; CESC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -7.76 -0.43 1.81e-13 Tonsillectomy; CESC cis rs4925386 0.921 rs11204472 chr20:60920887 G/A cg15193198 chr20:60906057 LAMA5 0.28 5.1 0.3 6.37e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs9457247 1.000 rs239935 chr6:167411788 G/A cg07741184 chr6:167504864 NA 0.3 5.46 0.32 1.11e-7 Crohn's disease; CESC cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg25405998 chr7:65216604 CCT6P1 0.45 5.08 0.3 7.23e-7 Aortic root size; CESC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg05313129 chr8:58192883 C8orf71 -0.56 -6.45 -0.37 5.22e-10 Developmental language disorder (linguistic errors); CESC cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 5.39 0.31 1.52e-7 Breast cancer; CESC cis rs712039 0.617 rs60118041 chr17:35803252 G/A cg16670864 chr17:35848621 DUSP14 0.41 5.13 0.3 5.52e-7 Tuberculosis; CESC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg04944784 chr2:26401820 FAM59B 0.96 10.5 0.54 8.76e-22 Gut microbiome composition (summer); CESC cis rs9399137 0.507 rs4896129 chr6:135349845 C/T cg22676075 chr6:135203613 NA 0.53 7.15 0.4 8.67e-12 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs2204008 0.715 rs11514282 chr12:38169056 G/T cg13010199 chr12:38710504 ALG10B 0.55 6.84 0.39 5.39e-11 Bladder cancer; CESC cis rs7772486 0.875 rs9403768 chr6:146406458 A/C cg05347473 chr6:146136440 FBXO30 0.5 6.55 0.37 2.93e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9303401 1.000 rs1390006 chr17:56890663 C/T cg12560992 chr17:57184187 TRIM37 -0.49 -5.53 -0.32 7.66e-8 Cognitive test performance; CESC cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs806215 1.000 rs806214 chr7:127237003 C/T cg25922125 chr7:127225783 GCC1 -0.44 -5.22 -0.31 3.67e-7 Type 2 diabetes; CESC cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.55e-7 Colonoscopy-negative controls vs population controls; CESC cis rs798554 0.655 rs798492 chr7:2799184 C/T cg13628971 chr7:2884303 GNA12 -0.39 -5.23 -0.31 3.43e-7 Height; CESC cis rs9640161 0.830 rs7800196 chr7:150061534 C/G cg17279839 chr7:150038598 RARRES2 0.4 5.46 0.32 1.11e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08450501 chr3:136580965 NCK1 0.6 6.3 0.36 1.22e-9 Gut microbiome composition (summer); CESC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.44 -0.32 1.19e-7 Aortic root size; CESC cis rs7917772 0.503 rs10748825 chr10:104293609 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.41 0.41 1.67e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs11718455 0.767 rs9861276 chr3:43989595 C/T cg08738300 chr3:44038990 NA 0.43 5.66 0.33 3.93e-8 Coronary artery disease; CESC cis rs10883723 0.810 rs7090276 chr10:104281239 G/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.18 0.3 4.34e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs1109430 0.661 rs4844509 chr1:210338874 G/T cg02304930 chr1:210405566 SERTAD4;C1orf133 -0.87 -7.22 -0.41 5.57e-12 Orofacial clefts; CESC cis rs68170813 0.559 rs12540475 chr7:106886295 C/T cg02696742 chr7:106810147 HBP1 -0.52 -5.08 -0.3 7.2e-7 Coronary artery disease; CESC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.73 6.82 0.39 6.2e-11 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18108695 chr21:46962546 SLC19A1 0.54 6.16 0.35 2.75e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.921 rs6002333 chr22:41719469 C/T cg06481639 chr22:41940642 POLR3H -0.65 -6.95 -0.39 2.87e-11 Vitiligo; CESC cis rs992157 0.764 rs10932774 chr2:219191569 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.58 7.59 0.42 5.57e-13 Colorectal cancer; CESC cis rs11997175 0.595 rs6468204 chr8:33774748 T/C ch.8.33884649F chr8:33765107 NA 0.51 5.75 0.33 2.5e-8 Body mass index; CESC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg08027265 chr7:2291960 NA -0.43 -6.45 -0.37 5.18e-10 Schizophrenia; CESC cis rs72781680 0.950 rs72798404 chr2:24180125 C/T cg20701182 chr2:24300061 SF3B14 0.78 6.82 0.39 5.98e-11 Lymphocyte counts; CESC cis rs1008375 0.966 rs3796813 chr4:17591648 A/G cg27347728 chr4:17578864 LAP3 0.42 5.11 0.3 6.07e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1153858 1.000 rs16942568 chr15:45677390 T/C cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10822008 chr15:90437384 AP3S2 0.53 6.37 0.36 8.2e-10 Gut microbiome composition (summer); CESC cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg10523679 chr1:76189770 ACADM 0.63 6.08 0.35 4.14e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg02990361 chr1:107599529 PRMT6 -0.45 -5.15 -0.3 5.08e-7 Facial morphology (factor 21, depth of nasal alae); CESC cis rs17376456 0.877 rs10059230 chr5:93450347 A/G cg25358565 chr5:93447407 FAM172A 1.15 11.8 0.59 4.11e-26 Diabetic retinopathy; CESC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg13393036 chr8:95962371 TP53INP1 -0.44 -9.23 -0.49 8.8e-18 Type 2 diabetes; CESC cis rs2070488 0.965 rs7640050 chr3:38525864 A/C cg24069376 chr3:38537580 EXOG 0.5 9.07 0.49 2.76e-17 Electrocardiographic conduction measures; CESC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg23985595 chr17:80112537 CCDC57 0.43 6.68 0.38 1.44e-10 Life satisfaction; CESC cis rs12541635 0.932 rs1835267 chr8:107044435 C/T cg10147462 chr8:107024639 NA 0.42 5.97 0.34 7.44e-9 Age of smoking initiation; CESC cis rs11792861 0.890 rs3750465 chr9:111900677 T/C cg05043794 chr9:111880884 C9orf5 -0.42 -6.94 -0.39 3.04e-11 Menarche (age at onset); CESC cis rs7605827 0.893 rs6733695 chr2:15525714 T/C cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs4727027 0.866 rs2373438 chr7:148780287 C/A cg23158103 chr7:148848205 ZNF398 -0.4 -6.49 -0.37 4.19e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs11696501 0.739 rs4812938 chr20:44249919 T/A cg11783356 chr20:44313418 WFDC10B -0.35 -5.46 -0.32 1.1e-7 Brain structure; CESC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg07677032 chr17:61819896 STRADA -0.44 -5.62 -0.33 4.91e-8 Prudent dietary pattern; CESC cis rs2243480 1.000 rs1723267 chr7:65473314 G/A cg18252515 chr7:66147081 NA -1.19 -11.57 -0.58 2.56e-25 Diabetic kidney disease; CESC cis rs2652834 0.851 rs4238372 chr15:63351488 G/A cg05507819 chr15:63340323 TPM1 0.62 6.08 0.35 4.22e-9 HDL cholesterol; CESC cis rs7927592 0.956 rs10896348 chr11:68357368 T/C cg20283391 chr11:68216788 NA -0.48 -6.08 -0.35 4.28e-9 Total body bone mineral density; CESC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.65 0.58 1.32e-25 Alzheimer's disease; CESC cis rs2274273 0.588 rs7154831 chr14:55823965 A/C cg04306507 chr14:55594613 LGALS3 0.3 5.26 0.31 2.92e-7 Protein biomarker; CESC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg05313129 chr8:58192883 C8orf71 -0.56 -6.38 -0.37 7.65e-10 Developmental language disorder (linguistic errors); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26216002 chr1:10093067 UBE4B -0.44 -6.0 -0.35 6.54e-9 Asthma; CESC trans rs9467711 0.606 rs9366656 chr6:26434630 T/C cg06606381 chr12:133084897 FBRSL1 -0.82 -6.98 -0.39 2.4e-11 Autism spectrum disorder or schizophrenia; CESC cis rs2243480 1.000 rs10247526 chr7:65780696 T/G cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC cis rs1461503 0.966 rs10790545 chr11:122838350 G/C cg27398637 chr11:122830231 C11orf63 -0.56 -8.42 -0.46 2.35e-15 Menarche (age at onset); CESC cis rs9399135 0.967 rs9389256 chr6:135331254 A/C cg24558204 chr6:135376177 HBS1L 0.52 7.18 0.4 7.04e-12 Red blood cell count; CESC trans rs78049276 0.562 rs55965782 chr4:148378442 T/C cg13149281 chr14:23389818 RBM23;PRMT5 -0.7 -8.43 -0.46 2.19e-15 Pulse pressure; CESC cis rs9560113 0.573 rs9560133 chr13:112240013 C/A cg10483660 chr13:112241077 NA 0.41 7.02 0.4 1.86e-11 Menarche (age at onset); CESC cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg17366294 chr4:99064904 C4orf37 0.54 7.53 0.42 8.11e-13 Colonoscopy-negative controls vs population controls; CESC cis rs4704187 0.663 rs9654428 chr5:74466884 A/C cg03227963 chr5:74354835 NA 0.28 5.21 0.3 3.77e-7 Response to amphetamines; CESC cis rs1670533 1.000 rs6857085 chr4:1095920 C/A cg27284194 chr4:1044797 NA -0.47 -5.98 -0.34 7.28e-9 Recombination rate (females); CESC cis rs2898681 0.521 rs6833350 chr4:53740868 A/G cg00791764 chr4:53727839 RASL11B 0.54 5.37 0.31 1.7e-7 Optic nerve measurement (cup area); CESC cis rs698833 0.892 rs698797 chr2:44689905 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 6.12 0.35 3.42e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg02569458 chr12:86230093 RASSF9 0.49 7.62 0.42 4.61e-13 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07845895 chr21:34776100 IFNGR2 -0.62 -6.93 -0.39 3.22e-11 Gut microbiome composition (summer); CESC cis rs459571 0.959 rs460888 chr9:136913123 C/G cg13789015 chr9:136890014 NCRNA00094 0.57 8.16 0.45 1.4e-14 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02148352 chr8:30209571 NA -0.57 -6.55 -0.37 2.91e-10 Gut microbiome composition (summer); CESC cis rs892961 0.932 rs9916143 chr17:75409282 C/G cg05865280 chr17:75406074 SEPT9 -0.67 -14.22 -0.66 1.75e-34 Airflow obstruction; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02386725 chr1:162467755 UHMK1 -0.45 -6.09 -0.35 3.92e-9 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10690677 chr1:87019175 CLCA4 0.5 6.78 0.38 7.62e-11 Fibrinogen levels; CESC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.04 0.4 1.62e-11 Bipolar disorder; CESC cis rs977987 0.778 rs7206541 chr16:75436713 A/T cg03315344 chr16:75512273 CHST6 0.41 5.85 0.34 1.43e-8 Dupuytren's disease; CESC cis rs9682041 0.800 rs7643085 chr3:170070371 A/G cg11886554 chr3:170076028 SKIL 0.82 6.83 0.39 5.75e-11 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs947211 0.948 rs1775143 chr1:205755550 C/T cg14159672 chr1:205819179 PM20D1 0.41 5.3 0.31 2.45e-7 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27326226 chr13:20767778 GJB2 -0.54 -6.29 -0.36 1.29e-9 Gut microbiome composition (summer); CESC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg13114125 chr14:105738426 BRF1 -0.85 -10.46 -0.54 1.18e-21 Mean platelet volume;Platelet distribution width; CESC cis rs1465370 0.682 rs62471720 chr7:130016359 C/G cg04743876 chr7:130013617 NA 0.31 5.84 0.34 1.5e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs4595586 0.545 rs7307303 chr12:39368976 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs12893668 0.703 rs55751606 chr14:104028806 G/A cg24130564 chr14:104152367 KLC1 -0.47 -5.8 -0.34 1.87e-8 Reticulocyte count; CESC cis rs6893300 0.785 rs6895902 chr5:179201847 C/T cg14593053 chr5:179126677 CANX -0.46 -5.26 -0.31 3.02e-7 Resting heart rate; CESC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg09060608 chr5:178986726 RUFY1 0.49 7.0 0.39 2.12e-11 Lung cancer; CESC cis rs6088580 0.634 rs6120644 chr20:33023810 G/A cg06115741 chr20:33292138 TP53INP2 0.48 6.14 0.35 3e-9 Glomerular filtration rate (creatinine); CESC cis rs7608623 0.679 rs7561273 chr2:24247514 C/T cg20701182 chr2:24300061 SF3B14 0.38 5.22 0.31 3.55e-7 Obesity-related traits; CESC cis rs7937682 0.824 rs539524 chr11:111477325 A/G cg09085632 chr11:111637200 PPP2R1B -0.95 -14.88 -0.67 8.31e-37 Primary sclerosing cholangitis; CESC cis rs290268 0.838 rs290987 chr9:93563267 T/A cg02608019 chr9:93564028 SYK 0.63 9.64 0.51 4.92e-19 Platelet count; CESC cis rs6430585 1.000 rs6430585 chr2:136506927 A/C cg07169764 chr2:136633963 MCM6 -0.96 -13.1 -0.63 1.42e-30 Corneal structure; CESC cis rs1568889 0.877 rs57202579 chr11:28221677 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.37 0.54 2.26e-21 Bipolar disorder; CESC cis rs2243480 0.615 rs34363376 chr7:65939536 T/C cg12463550 chr7:65579703 CRCP 0.68 5.2 0.3 3.9e-7 Diabetic kidney disease; CESC cis rs258892 0.895 rs11960081 chr5:72064490 C/G cg21869765 chr5:72125136 TNPO1 -0.43 -5.35 -0.31 1.93e-7 Small cell lung carcinoma; CESC cis rs3820928 0.874 rs1949807 chr2:227891861 A/G cg05526886 chr2:227700861 RHBDD1 -0.45 -5.79 -0.34 1.96e-8 Pulmonary function; CESC trans rs61931739 0.500 rs11519123 chr12:34436478 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.46 0.42 1.25e-12 Morning vs. evening chronotype; CESC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg02428538 chr16:24856791 SLC5A11 0.6 6.1 0.35 3.72e-9 Intelligence (multi-trait analysis); CESC trans rs61931739 0.500 rs11615231 chr12:34413330 T/C cg26384229 chr12:38710491 ALG10B 0.69 10.44 0.54 1.39e-21 Morning vs. evening chronotype; CESC trans rs79976124 0.879 rs12214948 chr6:66633603 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 8.2 0.45 1.02e-14 Type 2 diabetes; CESC cis rs11249608 0.590 rs36051170 chr5:178447971 T/C cg21905437 chr5:178450457 ZNF879 0.6 8.59 0.47 7.5e-16 Pubertal anthropometrics; CESC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.44 -0.32 1.19e-7 Aortic root size; CESC cis rs6942756 0.806 rs9641846 chr7:128873679 G/A cg02491457 chr7:128862824 NA 0.64 9.54 0.51 1.02e-18 White matter hyperintensity burden; CESC cis rs9911578 0.967 rs6503893 chr17:57149695 G/A cg05425664 chr17:57184151 TRIM37 -0.54 -7.38 -0.41 2.07e-12 Intelligence (multi-trait analysis); CESC cis rs7267979 1.000 rs2424710 chr20:25283886 C/G cg08601574 chr20:25228251 PYGB 0.37 5.2 0.3 3.93e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2710642 0.821 rs56373728 chr2:63095792 G/A cg17519650 chr2:63277830 OTX1 0.57 7.26 0.41 4.23e-12 LDL cholesterol levels;LDL cholesterol; CESC cis rs11190604 1.000 rs3750630 chr10:102275780 A/G cg07080220 chr10:102295463 HIF1AN 0.63 6.11 0.35 3.57e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg04450456 chr4:17643702 FAM184B 0.36 5.15 0.3 5.16e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2228479 0.850 rs62054609 chr16:89816569 C/A cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.33e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72848980 0.706 rs11191732 chr10:105331761 G/A cg00126946 chr10:105363258 SH3PXD2A 0.5 6.69 0.38 1.3100000000000001e-10 White matter hyperintensity burden; CESC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg21770322 chr7:97807741 LMTK2 0.56 8.61 0.47 6.55e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs73206853 0.563 rs7960761 chr12:111164415 T/C cg04375036 chr12:111181819 PPP1CC -0.64 -5.09 -0.3 6.87e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.72 0.47 3.13e-16 Bipolar disorder; CESC cis rs1003719 0.680 rs2257091 chr21:38522618 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.0 -0.44 4.01e-14 Eye color traits; CESC cis rs6812193 0.518 rs6822055 chr4:77196188 C/T cg20311846 chr4:77356250 SHROOM3 -0.28 -5.23 -0.31 3.53e-7 Parkinson's disease; CESC cis rs9399135 0.636 rs7749106 chr6:135268142 G/A cg12549451 chr6:135224345 NA 0.37 5.5 0.32 8.9e-8 Red blood cell count; CESC cis rs1728785 1.000 rs6499181 chr16:68593002 A/T cg02972257 chr16:68554789 NA -0.59 -6.7 -0.38 1.23e-10 Ulcerative colitis; CESC cis rs1707322 0.685 rs28617418 chr1:46189526 T/A cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg00033643 chr7:134001901 SLC35B4 0.42 5.38 0.31 1.61e-7 Mean platelet volume; CESC cis rs11190604 1.000 rs10883513 chr10:102316964 A/G cg07080220 chr10:102295463 HIF1AN 0.66 6.07 0.35 4.51e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs559928 0.692 rs12146487 chr11:64026639 G/A cg18225595 chr11:63971243 STIP1 0.61 5.2 0.3 4.04e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC trans rs629535 0.547 rs72654095 chr8:70120770 A/G cg21567404 chr3:27674614 NA -0.84 -9.29 -0.5 5.78e-18 Dupuytren's disease; CESC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16586002 chr3:196594898 SENP5 0.53 6.01 0.35 6.03e-9 Gut microbiome composition (summer); CESC cis rs919433 0.889 rs6711624 chr2:198207607 C/G cg10820045 chr2:198174542 NA -0.4 -5.8 -0.34 1.84e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs72781680 0.898 rs56179550 chr2:23934867 C/T cg08917208 chr2:24149416 ATAD2B 1.1 10.15 0.53 1.18e-20 Lymphocyte counts; CESC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg10295955 chr4:187884368 NA -0.98 -17.53 -0.73 3.27e-46 Lobe attachment (rater-scored or self-reported); CESC cis rs113835537 0.529 rs17065 chr11:66277035 G/A cg22134325 chr11:66188745 NPAS4 0.45 7.09 0.4 1.2e-11 Airway imaging phenotypes; CESC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg27478167 chr7:817139 HEATR2 -0.47 -5.61 -0.33 5.18e-8 Cerebrospinal P-tau181p levels; CESC cis rs2929278 0.617 rs575082 chr15:44110142 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.52 -6.84 -0.39 5.34e-11 Schizophrenia; CESC cis rs1830074 1 rs1830074 chr7:6718674 T/C cg09896999 chr7:6746977 ZNF12 -0.31 -5.04 -0.3 8.69e-7 Body mass index; CESC cis rs10242455 0.702 rs78640327 chr7:99167139 G/C cg18809830 chr7:99032528 PTCD1 -0.88 -5.81 -0.34 1.79e-8 Blood metabolite levels; CESC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs2235642 0.701 rs2281230 chr16:1601767 T/C cg03771183 chr16:1608904 IFT140 0.38 5.39 0.31 1.53e-7 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00907473 chr1:90459283 ZNF326;LOC492303 0.51 6.56 0.37 2.76e-10 Fibrinogen levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14862950 chr11:66112661 BRMS1 -0.44 -6.41 -0.37 6.58e-10 Gambling; CESC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs138880 0.542 rs9616371 chr22:50306338 G/A cg02269571 chr22:50332266 NA -0.67 -6.59 -0.38 2.36e-10 Schizophrenia; CESC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg04315214 chr1:2043799 PRKCZ 0.53 9.3 0.5 5.59e-18 Height; CESC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg27121462 chr16:89883253 FANCA 0.53 6.51 0.37 3.79e-10 Vitiligo; CESC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.85e-10 Total body bone mineral density; CESC cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg26597838 chr10:835615 NA 0.71 8.13 0.45 1.61e-14 Eosinophil percentage of granulocytes; CESC cis rs6540559 0.543 rs650728 chr1:210433351 C/T cg23283495 chr1:209979779 IRF6 0.44 5.41 0.32 1.43e-7 Cleft lip with or without cleft palate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15005908 chr6:114292723 HDAC2 -0.45 -6.15 -0.35 2.78e-9 Fibrinogen levels; CESC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg12463550 chr7:65579703 CRCP -0.46 -5.9 -0.34 1.11e-8 Aortic root size; CESC cis rs9916302 0.851 rs677888 chr17:37461018 T/G cg15445000 chr17:37608096 MED1 -0.39 -5.94 -0.34 9.14e-9 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24339935 chr9:100174143 TDRD7 0.61 7.44 0.42 1.44e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02724903 chr13:114260339 TFDP1 -0.59 -6.81 -0.39 6.68e-11 Gut microbiome composition (summer); CESC cis rs8020095 0.571 rs8010261 chr14:67608117 C/T cg19548862 chr14:67692701 FAM71D -0.47 -5.74 -0.33 2.53e-8 Depression (quantitative trait); CESC cis rs62408225 1.000 rs1847472 chr6:90973159 A/C cg06866423 chr6:90926672 BACH2 -0.46 -5.38 -0.31 1.61e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs965469 0.779 rs2236121 chr20:3304320 A/G cg17110299 chr20:3385021 C20orf194 0.39 5.12 0.3 5.91e-7 IFN-related cytopenia; CESC cis rs858239 0.539 rs2178139 chr7:23191636 A/G cg23682824 chr7:23144976 KLHL7 0.51 6.77 0.38 8.05e-11 Cerebrospinal fluid biomarker levels; CESC cis rs12477438 0.765 rs12612688 chr2:99613091 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -8.52 -0.46 1.23e-15 Chronic sinus infection; CESC cis rs7819412 0.775 rs4545055 chr8:10935366 T/C cg21775007 chr8:11205619 TDH -0.37 -5.06 -0.3 7.87e-7 Triglycerides; CESC cis rs2645694 0.626 rs2703124 chr4:77820626 G/T cg18351406 chr4:77819688 ANKRD56 0.55 6.88 0.39 4.42e-11 Emphysema distribution in smoking; CESC cis rs2108622 0.727 rs9305069 chr19:15983386 A/G cg13772218 chr19:15982569 NA 0.31 6.04 0.35 5.12e-9 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg22920501 chr2:26401640 FAM59B -0.84 -9.34 -0.5 4.02e-18 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs5757203 chr22:39044152 G/C cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC cis rs2046867 0.862 rs11922180 chr3:72836119 A/G cg25664220 chr3:72788482 NA 0.45 6.53 0.37 3.36e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs12497850 1.000 rs10865952 chr3:48744484 A/G cg02487422 chr3:49467188 NICN1 0.4 5.13 0.3 5.69e-7 Parkinson's disease; CESC cis rs1729951 0.575 rs1654923 chr3:136692620 A/T cg25687071 chr3:136751404 NA 0.39 5.19 0.3 4.27e-7 Neuroticism; CESC cis rs11098499 0.697 rs28458294 chr4:120238924 T/C cg09307838 chr4:120376055 NA 0.78 10.39 0.54 1.94e-21 Corneal astigmatism; CESC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.58 0.37 2.51e-10 Bipolar disorder; CESC cis rs826838 1.000 rs826838 chr12:39106731 C/T cg26384229 chr12:38710491 ALG10B -0.62 -9.94 -0.52 5.55e-20 Heart rate; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20697630 chr1:20960374 PINK1 -0.45 -6.13 -0.35 3.26e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1003719 0.646 rs2835671 chr21:38581125 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.07 -0.44 2.45e-14 Eye color traits; CESC cis rs950169 0.845 rs4502182 chr15:84923520 A/G cg17507749 chr15:85114479 UBE2QP1 0.57 6.33 0.36 1.04e-9 Schizophrenia; CESC cis rs10129255 0.556 rs8010005 chr14:107186226 A/G cg07958169 chr14:107095056 NA -0.54 -8.51 -0.46 1.3e-15 Kawasaki disease; CESC cis rs7267979 1.000 rs2257432 chr20:25271086 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.62 0.75 4.72e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs9790314 1.000 rs4597724 chr3:160963110 A/G cg04691961 chr3:161091175 C3orf57 -0.42 -5.44 -0.32 1.2e-7 Morning vs. evening chronotype; CESC cis rs7659604 1.000 rs6814995 chr4:122664963 A/T cg19748678 chr4:122722346 EXOSC9 -0.45 -5.38 -0.31 1.65e-7 Type 2 diabetes; CESC cis rs9658691 0.607 rs34891735 chr10:90779212 A/T cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -5.33 -0.31 2.13e-7 Mosquito bite size; CESC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg08888203 chr3:10149979 C3orf24 0.46 5.99 0.35 6.66e-9 Alzheimer's disease; CESC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs8114671 0.562 rs6120758 chr20:33492523 C/T cg07148914 chr20:33460835 GGT7 0.46 6.13 0.35 3.19e-9 Height; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg15598609 chr8:102239510 NA 0.42 6.05 0.35 5.01e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg00684032 chr4:1343700 KIAA1530 0.4 5.51 0.32 8.35e-8 Obesity-related traits; CESC cis rs3741151 0.656 rs12290785 chr11:73259012 G/T cg17517138 chr11:73019481 ARHGEF17 0.86 6.82 0.39 6.26e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs10276381 1.000 rs7796417 chr7:28186119 G/C cg23620719 chr7:28220237 JAZF1 0.74 7.96 0.44 5.1e-14 Crohn's disease; CESC cis rs637571 0.522 rs1786175 chr11:65754808 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 5.99 0.35 6.68e-9 Eosinophil percentage of white cells; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg01078248 chr7:123197661 NDUFA5 0.49 6.4 0.37 6.89e-10 Obesity-related traits; CESC cis rs10461617 0.512 rs7715746 chr5:56048837 C/T cg22800045 chr5:56110881 MAP3K1 0.6 7.55 0.42 6.87e-13 Type 2 diabetes; CESC cis rs734999 0.566 rs10797435 chr1:2534801 G/C cg18854424 chr1:2615690 NA 0.27 5.24 0.31 3.32e-7 Ulcerative colitis; CESC cis rs9911578 0.967 rs686425 chr17:56776730 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.97 -0.39 2.5e-11 Intelligence (multi-trait analysis); CESC cis rs7949030 0.653 rs2516634 chr11:62367186 G/A cg22862634 chr11:62369728 EML3;MTA2 -0.53 -7.37 -0.41 2.15e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs4964805 0.657 rs11111781 chr12:104187440 C/T cg02344784 chr12:104178138 NT5DC3 0.47 6.73 0.38 1.04e-10 Attention deficit hyperactivity disorder; CESC cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg01579765 chr21:45077557 HSF2BP -0.52 -8.54 -0.46 1.05e-15 Mean corpuscular volume; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg25934064 chr3:52569026 NT5DC2 0.26 5.53 0.32 7.53e-8 Bipolar disorder; CESC cis rs17826219 0.706 rs28469200 chr17:29133572 T/A cg13385521 chr17:29058706 SUZ12P 0.77 6.37 0.36 8.45e-10 Body mass index; CESC cis rs262147 0.610 rs2657363 chr7:158684273 C/T cg02254261 chr7:158964346 NA -0.69 -5.62 -0.33 4.82e-8 Hippocampal volume; CESC trans rs9467711 0.659 rs3734542 chr6:26468326 G/A cg01620082 chr3:125678407 NA -0.76 -6.33 -0.36 1.05e-9 Autism spectrum disorder or schizophrenia; CESC cis rs17253792 0.822 rs13379353 chr14:56050478 G/C cg01858014 chr14:56050164 KTN1 -0.92 -7.38 -0.41 2.06e-12 Putamen volume; CESC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg11663144 chr21:46675770 NA -0.51 -7.1 -0.4 1.15e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -6.96 -0.39 2.67e-11 Personality dimensions; CESC cis rs2235642 0.787 rs2235646 chr16:1601287 A/G cg07639376 chr16:1584516 IFT140;TMEM204 -0.32 -5.11 -0.3 6.21e-7 Coronary artery disease; CESC trans rs10435719 0.867 rs6999030 chr8:11795308 G/A cg15556689 chr8:8085844 FLJ10661 0.49 6.09 0.35 3.95e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CESC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg27125505 chr17:43679177 LOC644172 -0.48 -6.69 -0.38 1.34e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs909674 0.865 rs5757683 chr22:39850174 G/A cg01416388 chr22:39784598 NA -0.58 -6.97 -0.39 2.56e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs2760061 0.598 rs590657 chr1:228117581 A/C cg01973587 chr1:228161476 NA 0.35 5.31 0.31 2.32e-7 Diastolic blood pressure; CESC trans rs13160161 0.507 rs13182733 chr5:39049988 C/G cg09550024 chr10:96698366 CYP2C9 -0.47 -6.15 -0.35 2.89e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15722731 chr6:122720674 HSF2 0.66 8.46 0.46 1.83e-15 Gut microbiome composition (summer); CESC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg08109568 chr15:31115862 NA 0.73 10.06 0.53 2.26e-20 Huntington's disease progression; CESC cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg12463550 chr7:65579703 CRCP 0.67 5.38 0.31 1.67e-7 Diabetic kidney disease; CESC cis rs10911232 0.524 rs10911209 chr1:183013988 T/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.67 0.64 1.52e-32 Hypertriglyceridemia; CESC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.27 0.41 4.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg19163074 chr7:65112434 INTS4L2 -0.41 -5.18 -0.3 4.32e-7 Aortic root size; CESC cis rs6831352 0.838 rs2851250 chr4:100044113 G/C cg13256891 chr4:100009986 ADH5 0.74 8.21 0.45 9.57e-15 Alcohol dependence; CESC cis rs7267979 1.000 rs2482928 chr20:25331530 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -16.43 -0.71 2.69e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs4835473 0.864 rs57137521 chr4:144625198 T/A cg25736465 chr4:144833511 NA -0.37 -5.54 -0.32 7.12e-8 Immature fraction of reticulocytes; CESC trans rs1814175 0.817 rs7929173 chr11:49944007 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -21.21 -0.79 4.77e-59 Height; CESC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg04248312 chr19:17393744 ANKLE1 0.93 14.99 0.68 3.44e-37 Systemic lupus erythematosus; CESC trans rs57221529 0.766 rs72703064 chr5:587825 T/C cg25482853 chr8:67687455 SGK3 1.01 9.99 0.52 3.67e-20 Lung disease severity in cystic fibrosis; CESC cis rs1050631 1.000 rs1107840 chr18:33707164 A/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.45 5.83 0.34 1.6e-8 Esophageal squamous cell cancer (length of survival); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23895234 chr1:26561325 CCDC21 0.58 6.34 0.36 9.86e-10 Gut microbiome composition (summer); CESC cis rs644799 0.509 rs561635 chr11:95634232 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.46 -6.04 -0.35 5.32e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs897984 0.542 rs11865038 chr16:31095171 C/T cg00531865 chr16:30841666 NA -0.39 -5.42 -0.32 1.33e-7 Dementia with Lewy bodies; CESC cis rs6598955 0.670 rs11247892 chr1:26592727 A/G cg04990556 chr1:26633338 UBXN11 -0.73 -10.29 -0.53 4.21e-21 Obesity-related traits; CESC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.67 8.91 0.48 8.58e-17 Total body bone mineral density; CESC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg00166722 chr3:10149974 C3orf24 0.51 6.26 0.36 1.58e-9 Alzheimer's disease; CESC cis rs6582630 0.576 rs4882375 chr12:38371939 G/T cg26384229 chr12:38710491 ALG10B -0.43 -5.59 -0.32 5.6e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs654950 0.841 rs2759247 chr1:41991756 G/C cg06885757 chr1:42089581 HIVEP3 -0.44 -6.75 -0.38 9.38e-11 Airway imaging phenotypes; CESC cis rs2070433 0.851 rs8129793 chr21:47925719 T/C cg12379764 chr21:47803548 PCNT 0.49 5.97 0.34 7.67e-9 Lymphocyte counts; CESC cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg11279151 chr3:101281821 RG9MTD1 -0.5 -5.55 -0.32 7.07e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 7.43 0.42 1.45e-12 Electroencephalogram traits; CESC cis rs2637266 0.739 rs2579768 chr10:78415481 A/G cg18941641 chr10:78392320 NA 0.4 7.34 0.41 2.6e-12 Pulmonary function; CESC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg00166722 chr3:10149974 C3orf24 0.51 6.06 0.35 4.6e-9 Alzheimer's disease; CESC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg18180107 chr4:99064573 C4orf37 0.42 5.23 0.31 3.45e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg24110177 chr3:50126178 RBM5 -0.52 -7.06 -0.4 1.42e-11 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07483432 chr12:72079704 TMEM19 0.47 6.75 0.38 9.32e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04139749 chr14:77786727 GSTZ1;POMT2 0.48 6.2 0.36 2.21e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg14983838 chr19:29218262 NA 0.5 6.16 0.35 2.67e-9 Methadone dose in opioid dependence; CESC cis rs6752107 1.000 rs13391356 chr2:234170369 T/C cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.38 5.83 0.34 1.61e-8 Crohn's disease;Inflammatory bowel disease; CESC trans rs1945213 0.694 rs11227181 chr11:55856053 C/T cg03929089 chr4:120376271 NA 0.77 7.35 0.41 2.48e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs57244997 0.872 rs11759694 chr6:162405705 C/G cg17173639 chr6:162384350 PARK2 0.69 7.17 0.4 7.53e-12 Mosquito bite size; CESC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg17650747 chr5:1873721 NA 0.4 5.58 0.32 5.96e-8 Cardiovascular disease risk factors; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11201273 chr8:38088865 DDHD2 -0.52 -6.36 -0.36 8.91e-10 Ulcerative colitis; CESC cis rs17666538 0.535 rs4338080 chr8:615598 A/G cg02524346 chr8:600233 NA 0.83 6.05 0.35 4.92e-9 IgG glycosylation; CESC cis rs11711311 1.000 rs62268169 chr3:113493860 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.71 9.99 0.52 3.72e-20 IgG glycosylation; CESC cis rs5753037 0.809 rs140150 chr22:30185719 C/G cg01021169 chr22:30184971 ASCC2 -0.38 -5.03 -0.3 9.16e-7 Type 1 diabetes; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03900353 chr1:212732456 NA 0.46 6.1 0.35 3.78e-9 Systemic lupus erythematosus; CESC cis rs7605827 0.930 rs11692646 chr2:15559198 C/G cg19274914 chr2:15703543 NA -0.38 -6.93 -0.39 3.19e-11 Educational attainment (years of education); CESC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.65 -0.38 1.69e-10 Life satisfaction; CESC cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg15017067 chr4:17643749 FAM184B 0.38 5.39 0.31 1.54e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04925196 chr12:51592141 POU6F1 0.52 6.83 0.39 5.95e-11 Fibrinogen levels; CESC cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg21926612 chr6:163149169 PACRG;PARK2 1.03 10.8 0.55 8.68e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg14711859 chr11:8959438 ASCL3 0.34 5.48 0.32 9.95e-8 Hemoglobin concentration; CESC cis rs1545257 0.505 rs894466 chr2:24633771 T/C cg06627628 chr2:24431161 ITSN2 -0.47 -5.62 -0.33 4.94e-8 Sjögren's syndrome; CESC cis rs11264213 0.901 rs55762724 chr1:36382702 C/T cg27506609 chr1:36549197 TEKT2 0.66 5.55 0.32 6.79e-8 Schizophrenia; CESC cis rs9831754 0.704 rs6774325 chr3:78458727 G/A cg06138941 chr3:78371609 NA -0.49 -6.11 -0.35 3.54e-9 Calcium levels; CESC cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg22875332 chr1:76189707 ACADM 0.73 10.04 0.53 2.51e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.6 -8.71 -0.47 3.35e-16 Personality dimensions; CESC cis rs2072732 0.861 rs12034794 chr1:2937551 T/G cg15211996 chr1:2936768 ACTRT2 0.35 5.74 0.33 2.63e-8 Plateletcrit; CESC cis rs10754283 0.967 rs10737706 chr1:90112579 G/T cg21401794 chr1:90099060 LRRC8C 0.7 9.44 0.5 1.97e-18 Amyotrophic lateral sclerosis (sporadic); CESC trans rs208520 0.690 rs74707865 chr6:66717352 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.24 0.6 1.32e-27 Exhaled nitric oxide output; CESC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg17747265 chr1:1875780 NA -0.56 -9.11 -0.49 2.1e-17 Body mass index; CESC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg18876405 chr7:65276391 NA -0.53 -7.25 -0.41 4.64e-12 Aortic root size; CESC cis rs1003719 0.788 rs4817845 chr21:38447132 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.7 0.47 3.48e-16 Eye color traits; CESC cis rs7927592 0.513 rs7950129 chr11:68202903 A/G cg01657329 chr11:68192670 LRP5 -0.55 -7.22 -0.41 5.47e-12 Total body bone mineral density; CESC cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg18230493 chr5:56204884 C5orf35 0.6 7.88 0.44 8.63e-14 Initial pursuit acceleration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10446143 chr21:44394730 PKNOX1 0.53 7.09 0.4 1.22e-11 Gut microbiota (bacterial taxa); CESC cis rs67311347 1.000 rs7612015 chr3:40399974 A/C cg09455208 chr3:40491958 NA 0.45 7.85 0.43 1.06e-13 Renal cell carcinoma; CESC cis rs9457247 0.756 rs2345572 chr6:167403441 A/T cg25258033 chr6:167368657 RNASET2 0.39 5.83 0.34 1.64e-8 Crohn's disease; CESC cis rs9399137 0.507 rs6940878 chr6:135366309 G/A cg22676075 chr6:135203613 NA 0.55 7.36 0.41 2.37e-12 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs1005277 0.540 rs2145487 chr10:38010077 A/G cg00409905 chr10:38381863 ZNF37A -0.5 -6.82 -0.39 6.06e-11 Extrinsic epigenetic age acceleration; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg03760483 chr17:6899297 ALOX12 0.42 7.47 0.42 1.13e-12 Tonsillectomy; CESC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg08027265 chr7:2291960 NA -0.34 -5.08 -0.3 7.23e-7 Bipolar disorder and schizophrenia; CESC cis rs17401966 1.000 rs11121552 chr1:10435324 C/A cg15208524 chr1:10270712 KIF1B 0.49 6.21 0.36 2.04e-9 Hepatocellular carcinoma; CESC cis rs950169 0.526 rs698620 chr15:85177208 G/A cg12501888 chr15:85177176 SCAND2 -0.51 -6.84 -0.39 5.41e-11 Schizophrenia; CESC cis rs6565180 0.962 rs6565182 chr16:30374381 C/T cg17640201 chr16:30407289 ZNF48 -0.92 -13.42 -0.64 1.15e-31 Tonsillectomy; CESC cis rs8038465 0.592 rs58443257 chr15:73930707 A/T cg15420318 chr15:73925796 NPTN 0.47 6.68 0.38 1.41e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs8028182 0.549 rs10775209 chr15:75634759 G/A cg20655648 chr15:75932815 IMP3 -0.43 -5.34 -0.31 2.03e-7 Sudden cardiac arrest; CESC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg06484146 chr7:12443880 VWDE 0.75 10.63 0.55 3.35e-22 Coronary artery disease; CESC trans rs35110281 0.837 rs2838341 chr21:45076443 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 6.69 0.38 1.33e-10 Mean corpuscular volume; CESC cis rs2281558 0.583 rs7260957 chr20:25722462 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.5 5.63 0.33 4.51e-8 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg22968622 chr17:43663579 NA 1.27 17.97 0.74 9.18e-48 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9875589 0.509 rs1601870 chr3:14024162 T/C cg19554555 chr3:13937349 NA -0.43 -5.66 -0.33 4.01e-8 Ovarian reserve; CESC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.64 0.43 3.85e-13 Prudent dietary pattern; CESC cis rs2522056 0.932 rs2522064 chr5:131806488 G/A cg24060327 chr5:131705240 SLC22A5 0.61 6.89 0.39 4.11e-11 Lymphocyte counts;Fibrinogen; CESC trans rs116095464 0.558 rs112343653 chr5:257174 G/A cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.35e-11 Breast cancer; CESC cis rs10883723 0.810 rs2296588 chr10:104248087 T/C cg22532475 chr10:104410764 TRIM8 -0.34 -5.72 -0.33 2.86e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs6429082 0.818 rs291340 chr1:235674379 C/T cg26050004 chr1:235667680 B3GALNT2 0.66 8.03 0.44 3.27e-14 Adiposity; CESC cis rs5753618 0.504 rs8142121 chr22:31882785 G/A cg13145458 chr22:31556086 RNF185 -0.51 -5.89 -0.34 1.19e-8 Colorectal cancer; CESC cis rs10129255 0.500 rs8014529 chr14:107192302 G/A cg23076370 chr14:107095027 NA -0.65 -9.53 -0.51 1.09e-18 Kawasaki disease; CESC cis rs3091242 0.935 rs4233043 chr1:25765483 A/G cg03538708 chr1:25844672 NA -0.39 -5.87 -0.34 1.31e-8 Erythrocyte sedimentation rate; CESC cis rs2370759 1.000 rs79806114 chr10:32618022 T/C cg18270830 chr10:32634957 EPC1 0.71 6.75 0.38 9.25e-11 Sexual dysfunction (female); CESC cis rs11648796 0.765 rs2003832 chr16:769538 G/A cg09781414 chr16:715207 WDR90 -0.42 -5.16 -0.3 4.87e-7 Height; CESC cis rs9811920 0.965 rs9289981 chr3:99868104 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.41 5.48 0.32 1.01e-7 Axial length; CESC cis rs7819412 0.807 rs4840542 chr8:10944809 G/T cg21775007 chr8:11205619 TDH -0.42 -5.66 -0.33 3.99e-8 Triglycerides; CESC cis rs2486288 0.656 rs8041702 chr15:45547093 C/T cg09092052 chr15:45571596 NA 0.48 5.63 0.33 4.53e-8 Glomerular filtration rate; CESC cis rs17253792 0.822 rs10151664 chr14:56029533 A/G cg01858014 chr14:56050164 KTN1 -0.84 -7.0 -0.4 2.1e-11 Putamen volume; CESC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg07701084 chr6:150067640 NUP43 0.45 6.27 0.36 1.42e-9 Lung cancer; CESC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg12311346 chr5:56204834 C5orf35 0.78 9.45 0.5 1.93e-18 Initial pursuit acceleration; CESC cis rs56104184 0.775 rs56149557 chr19:49401384 C/A cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs9388451 0.537 rs1739383 chr6:126098915 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.56 -7.42 -0.41 1.59e-12 Brugada syndrome; CESC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg05754148 chr16:3507555 NAT15 0.67 6.43 0.37 5.88e-10 Tuberculosis; CESC cis rs9916302 0.706 rs8075737 chr17:37727316 C/T cg20243544 chr17:37824526 PNMT -0.53 -5.57 -0.32 6.26e-8 Glomerular filtration rate (creatinine); CESC cis rs61931739 0.500 rs11053243 chr12:34514155 T/C cg06521331 chr12:34319734 NA -0.37 -5.09 -0.3 6.85e-7 Morning vs. evening chronotype; CESC cis rs2072732 0.861 rs6679678 chr1:2950594 T/C cg15211996 chr1:2936768 ACTRT2 0.34 5.95 0.34 8.31e-9 Plateletcrit; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00692549 chr1:11072455 TARDBP 0.46 6.31 0.36 1.18e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2191566 0.576 rs393195 chr19:44493142 T/G cg20607764 chr19:44506953 ZNF230 0.41 5.17 0.3 4.57e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs56046484 0.956 rs17541572 chr15:85665247 C/T cg08123816 chr15:85640762 PDE8A 0.5 6.0 0.35 6.52e-9 Testicular germ cell tumor; CESC cis rs12477438 1.000 rs11897712 chr2:99735697 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -7.79 -0.43 1.54e-13 Chronic sinus infection; CESC cis rs11638352 1.000 rs2412852 chr15:44303086 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -5.16 -0.3 4.75e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.43 -5.85 -0.34 1.46e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23182539 chr10:121355708 TIAL1 -0.45 -6.03 -0.35 5.41e-9 Height; CESC cis rs703842 1.000 rs10877019 chr12:58172929 A/G cg18357645 chr12:58087776 OS9 0.42 5.8 0.34 1.88e-8 Multiple sclerosis; CESC cis rs1707322 1.000 rs9429186 chr1:46539687 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.55 -0.32 7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg15112475 chr7:1198522 ZFAND2A -0.44 -7.12 -0.4 1.04e-11 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26357606 chr6:43230825 TTBK1 -0.52 -6.07 -0.35 4.39e-9 Gut microbiome composition (summer); CESC cis rs117623576 0.941 rs72778716 chr10:32370541 G/A cg03047570 chr10:32398778 NA -0.79 -7.14 -0.4 8.95e-12 Anti-saccade response; CESC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 7.08 0.4 1.3e-11 Platelet count; CESC cis rs752010 0.967 rs752011 chr1:42092929 C/T cg06885757 chr1:42089581 HIVEP3 0.49 7.94 0.44 5.62e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.44 0.32 1.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg00080972 chr5:178986291 RUFY1 0.44 6.81 0.39 6.34e-11 Lung cancer; CESC cis rs78889164 0.956 rs79661676 chr19:33863054 C/T cg02272751 chr19:33882848 PEPD -0.5 -6.67 -0.38 1.5e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs561341 0.882 rs16967101 chr17:30377162 A/G cg00745463 chr17:30367425 LRRC37B -0.62 -6.07 -0.35 4.46e-9 Hip circumference adjusted for BMI; CESC cis rs2857078 0.720 rs9906669 chr17:42305706 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.41 5.1 0.3 6.35e-7 Red cell distribution width;Reticulocyte count; CESC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg06456125 chr7:65229604 NA -0.4 -5.13 -0.3 5.51e-7 Aortic root size; CESC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg26335602 chr6:28129616 ZNF389 0.52 6.85 0.39 5.22e-11 Depression; CESC cis rs7216064 1.000 rs4791212 chr17:65975385 C/T cg07042672 chr17:66097459 LOC651250 -0.54 -5.84 -0.34 1.55e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs4950322 0.518 rs4950304 chr1:146588267 C/T cg04954894 chr8:38089920 DDHD2 -0.58 -6.2 -0.36 2.14e-9 Protein quantitative trait loci; CESC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg03709012 chr19:19516395 GATAD2A -0.99 -15.52 -0.69 4.48e-39 Tonsillectomy; CESC cis rs11098499 0.863 rs11731756 chr4:120478696 T/G cg24375607 chr4:120327624 NA 0.45 5.51 0.32 8.55e-8 Corneal astigmatism; CESC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg21724239 chr8:58056113 NA 0.56 5.25 0.31 3.19e-7 Developmental language disorder (linguistic errors); CESC cis rs12900413 0.603 rs2351494 chr15:90299541 C/T cg24249390 chr15:90295951 MESP1 -0.4 -5.42 -0.32 1.33e-7 Coronary artery aneurysm in Kawasaki disease; CESC trans rs7819412 0.668 rs2409721 chr8:11038244 A/T cg06636001 chr8:8085503 FLJ10661 -0.62 -7.98 -0.44 4.38e-14 Triglycerides; CESC cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg24308560 chr3:49941425 MST1R -0.64 -9.3 -0.5 5.56e-18 Intelligence (multi-trait analysis); CESC cis rs13108904 0.967 rs900029 chr4:1279145 C/T cg00684032 chr4:1343700 KIAA1530 0.4 5.58 0.32 6e-8 Obesity-related traits; CESC cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg05265849 chr7:22767390 IL6 0.54 6.81 0.39 6.34e-11 Lung cancer; CESC cis rs7808935 0.789 rs2040668 chr7:27958773 G/T cg05786569 chr7:27702416 HIBADH -0.49 -5.49 -0.32 9.4e-8 Prostate cancer; CESC cis rs2573652 0.722 rs11636084 chr15:100543394 A/G cg09918751 chr15:100517450 ADAMTS17 -0.29 -5.48 -0.32 9.68e-8 Height; CESC cis rs2576037 0.796 rs6507718 chr18:44581284 G/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -5.15 -0.3 4.98e-7 Personality dimensions; CESC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg01988459 chr11:68622903 NA -0.49 -6.94 -0.39 2.98e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8067354 0.830 rs2453913 chr17:57860150 G/T cg13753209 chr17:57696993 CLTC 0.49 6.69 0.38 1.29e-10 Hemoglobin concentration; CESC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg06873352 chr17:61820015 STRADA 0.72 12.78 0.62 1.79e-29 Prudent dietary pattern; CESC cis rs9325144 0.534 rs6582538 chr12:38629997 A/C cg26384229 chr12:38710491 ALG10B -0.59 -9.01 -0.48 4.09e-17 Morning vs. evening chronotype; CESC cis rs2273669 0.667 rs116189763 chr6:109302894 T/C cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC cis rs17401966 0.858 rs61778404 chr1:10432879 A/G cg15208524 chr1:10270712 KIF1B 0.4 5.15 0.3 5.09e-7 Hepatocellular carcinoma; CESC cis rs6963495 0.556 rs818481 chr7:105158467 G/C cg13798780 chr7:105162888 PUS7 0.51 6.3 0.36 1.26e-9 Bipolar disorder (body mass index interaction); CESC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg25072359 chr17:41440525 NA 0.46 6.06 0.35 4.72e-9 Menopause (age at onset); CESC cis rs2273669 0.667 rs11153156 chr6:109365911 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg09704049 chr3:38348016 SLC22A14 0.45 6.29 0.36 1.31e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CESC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg20243544 chr17:37824526 PNMT -0.44 -5.45 -0.32 1.13e-7 Glomerular filtration rate (creatinine); CESC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.35 -0.36 9.29e-10 Intelligence (multi-trait analysis); CESC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg06634786 chr22:41940651 POLR3H -0.68 -6.73 -0.38 1.03e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs10788264 0.544 rs9630110 chr10:124017308 C/T cg09507567 chr10:124027408 NA -0.42 -5.86 -0.34 1.36e-8 Total body bone mineral density; CESC cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg12641515 chr19:46296257 DMWD 0.73 9.82 0.52 1.34e-19 Coronary artery disease; CESC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.85 12.01 0.59 8.38e-27 Age-related macular degeneration (geographic atrophy); CESC cis rs27434 0.583 rs34759 chr5:96153133 T/C cg16492584 chr5:96139282 ERAP1 -0.38 -5.54 -0.32 7.47e-8 Ankylosing spondylitis; CESC cis rs6570726 0.905 rs421032 chr6:145827771 A/G cg05347473 chr6:146136440 FBXO30 0.44 5.99 0.35 6.71e-9 Lobe attachment (rater-scored or self-reported); CESC trans rs11039798 0.777 rs2202454 chr11:49011009 T/C cg15704280 chr7:45808275 SEPT13 0.69 6.46 0.37 4.91e-10 Axial length; CESC cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg00701064 chr4:6280414 WFS1 0.7 12.37 0.61 4.71e-28 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1018836 0.923 rs10956748 chr8:91621537 T/A cg16814680 chr8:91681699 NA -0.71 -9.99 -0.52 3.79e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg01416388 chr22:39784598 NA 0.55 6.97 0.39 2.47e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27184249 chr1:38010230 SNIP1 -0.6 -6.76 -0.38 8.63e-11 Gut microbiome composition (summer); CESC cis rs10191773 0.535 rs11685514 chr2:113100014 C/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.71 -7.55 -0.42 6.9e-13 Yeast infection; CESC cis rs3750965 1.000 rs3750965 chr11:68840160 A/G cg01403660 chr11:68851641 TPCN2 0.43 5.6 0.33 5.29e-8 Hair color; CESC cis rs4727027 0.704 rs2269972 chr7:148914047 C/T cg23583168 chr7:148888333 NA 0.93 16.39 0.71 3.53e-42 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03352830 chr11:487213 PTDSS2 -0.74 -7.21 -0.4 5.98e-12 Body mass index; CESC cis rs7192750 0.583 rs8046916 chr16:72047751 C/G cg14768367 chr16:72042858 DHODH -0.72 -5.69 -0.33 3.32e-8 LDL cholesterol levels;Total cholesterol levels; CESC cis rs7829975 0.714 rs7823757 chr8:8670177 T/A cg15556689 chr8:8085844 FLJ10661 0.43 5.44 0.32 1.2e-7 Mood instability; CESC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.01 10.08 0.53 1.98e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6912958 0.559 rs6921504 chr6:88058972 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.33 5.56 0.32 6.64e-8 Monocyte percentage of white cells; CESC cis rs228437 1.000 rs1474828 chr6:134926962 A/C cg24504307 chr6:134963096 NA 0.58 6.2 0.36 2.2e-9 Melanoma; CESC cis rs7666738 0.716 rs1426660 chr4:98876792 T/A cg05340658 chr4:99064831 C4orf37 0.75 11.16 0.57 5.89e-24 Colonoscopy-negative controls vs population controls; CESC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg16339924 chr4:17578868 LAP3 -0.76 -9.51 -0.5 1.22e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg08109568 chr15:31115862 NA -0.72 -9.73 -0.51 2.44e-19 Huntington's disease progression; CESC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg13880726 chr7:1868755 MAD1L1 0.52 7.14 0.4 8.73e-12 Bipolar disorder and schizophrenia; CESC cis rs2952156 0.920 rs9303274 chr17:37836353 T/C cg07936489 chr17:37558343 FBXL20 -0.6 -7.98 -0.44 4.39e-14 Asthma; CESC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg18099408 chr3:52552593 STAB1 -0.34 -5.7 -0.33 3.12e-8 Bipolar disorder; CESC trans rs10411161 0.702 rs11879436 chr19:52397815 T/A cg22319618 chr22:45562946 NUP50 -0.74 -7.44 -0.42 1.37e-12 Breast cancer; CESC cis rs2857078 0.720 rs9901595 chr17:42305699 G/A cg13607699 chr17:42295918 UBTF 0.78 11.36 0.57 1.25e-24 Red cell distribution width;Reticulocyte count; CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg26335602 chr6:28129616 ZNF389 0.54 7.25 0.41 4.48e-12 Depression; CESC cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg21361702 chr7:150065534 REPIN1 -0.53 -6.25 -0.36 1.62e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs4237845 0.773 rs6650218 chr12:58289078 T/A cg00677455 chr12:58241039 CTDSP2 0.44 5.78 0.33 2.09e-8 Intelligence (multi-trait analysis); CESC cis rs9914544 0.564 rs1859083 chr17:18843306 C/T cg26306683 chr17:18585705 ZNF286B -0.38 -5.54 -0.32 7.34e-8 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18452880 chr6:170151829 C6orf70;TCTE3 0.58 6.86 0.39 4.75e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02262025 chr16:75657287 ADAT1 0.53 6.11 0.35 3.59e-9 Gut microbiome composition (summer); CESC cis rs9325144 0.647 rs12231313 chr12:39101929 C/T cg26384229 chr12:38710491 ALG10B -0.5 -7.06 -0.4 1.47e-11 Morning vs. evening chronotype; CESC cis rs1800795 0.652 rs7802307 chr7:22766433 T/A cg13104385 chr7:22767384 IL6 0.38 5.23 0.31 3.48e-7 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CESC cis rs7107174 1.000 rs2510043 chr11:77977481 C/G cg02023728 chr11:77925099 USP35 0.39 5.79 0.34 1.99e-8 Testicular germ cell tumor; CESC cis rs919433 0.929 rs1366836 chr2:198172148 T/G cg10820045 chr2:198174542 NA -0.44 -6.93 -0.39 3.21e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7511006 1.000 rs17836662 chr22:50672154 A/G cg16473166 chr22:50639996 SELO -0.49 -6.13 -0.35 3.17e-9 Obesity-related traits; CESC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.26 0.31 3e-7 Menopause (age at onset); CESC cis rs2243480 1.000 rs36068983 chr7:65408991 C/T cg12463550 chr7:65579703 CRCP 0.7 5.58 0.32 5.87e-8 Diabetic kidney disease; CESC cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg17366294 chr4:99064904 C4orf37 0.57 8.16 0.45 1.4e-14 Colonoscopy-negative controls vs population controls; CESC cis rs3806843 1.000 rs1548701 chr5:140164557 T/C cg26395211 chr5:140044315 WDR55 -0.42 -5.43 -0.32 1.26e-7 Depressive symptoms (multi-trait analysis); CESC cis rs11030122 0.702 rs10835399 chr11:3989182 G/A cg18678763 chr11:4115507 RRM1 -0.47 -6.22 -0.36 1.92e-9 Mean platelet volume;Platelet distribution width; CESC cis rs12765878 1.000 rs11191847 chr10:105650626 G/C cg11005552 chr10:105648138 OBFC1 0.36 5.24 0.31 3.32e-7 Coronary artery disease; CESC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 10.96 0.56 2.75e-23 Platelet count; CESC cis rs965469 1.000 rs6051751 chr20:3310049 G/C cg25506879 chr20:3388711 C20orf194 -0.57 -6.15 -0.35 2.79e-9 IFN-related cytopenia; CESC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg06420487 chr17:61919686 SMARCD2 0.46 5.56 0.32 6.51e-8 Height; CESC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg07936489 chr17:37558343 FBXL20 0.78 11.03 0.56 1.58e-23 Glomerular filtration rate (creatinine); CESC cis rs911555 0.755 rs4143998 chr14:103955247 T/C cg24130564 chr14:104152367 KLC1 -0.5 -6.58 -0.37 2.56e-10 Intelligence (multi-trait analysis); CESC cis rs6968419 0.788 rs6946058 chr7:115839253 A/C cg02561103 chr7:115862891 TES -0.39 -5.26 -0.31 2.93e-7 Intraocular pressure; CESC cis rs5753618 0.504 rs9606847 chr22:31901789 G/C cg02404636 chr22:31891804 SFI1 0.42 5.85 0.34 1.47e-8 Colorectal cancer; CESC cis rs2228479 0.850 rs1800331 chr16:89858417 C/A cg19635926 chr16:89946313 TCF25 0.68 5.17 0.3 4.65e-7 Skin colour saturation; CESC cis rs13242816 1.000 rs67982517 chr7:116075363 A/G cg04696780 chr7:116139425 CAV2 -0.64 -5.73 -0.33 2.71e-8 P wave duration; CESC cis rs2243480 0.901 rs778730 chr7:65823325 T/A cg18252515 chr7:66147081 NA -1.4 -14.22 -0.66 1.75e-34 Diabetic kidney disease; CESC cis rs703842 0.963 rs923829 chr12:58174306 T/C cg18357645 chr12:58087776 OS9 -0.39 -5.55 -0.32 6.84e-8 Multiple sclerosis; CESC cis rs7402982 0.625 rs7179841 chr15:99204652 C/T cg03437748 chr15:99193247 IGF1R 0.61 7.81 0.43 1.3e-13 Birth weight; CESC cis rs12477438 0.520 rs4851187 chr2:99745860 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.83 -14.22 -0.66 1.71e-34 Chronic sinus infection; CESC cis rs6120849 0.754 rs1885117 chr20:33600740 C/T cg24642439 chr20:33292090 TP53INP2 0.67 6.69 0.38 1.3e-10 Protein C levels; CESC cis rs3845702 1.000 rs262279 chr2:180869145 G/A cg01881094 chr2:180872142 CWC22 0.65 6.99 0.39 2.21e-11 Schizophrenia; CESC cis rs9393777 0.623 rs9348719 chr6:26470032 T/C cg14345882 chr6:26364793 BTN3A2 0.43 5.4 0.31 1.5e-7 Intelligence (multi-trait analysis); CESC cis rs9457247 1.000 rs406095 chr6:167409087 C/T cg07741184 chr6:167504864 NA 0.3 5.52 0.32 8.06e-8 Crohn's disease; CESC cis rs2404618 0.506 rs12156177 chr8:1493684 C/T cg02903104 chr8:1507517 DLGAP2 0.29 5.56 0.32 6.42e-8 Lung cancer; CESC cis rs2072438 0.505 rs7034074 chr9:123923029 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.37 5.29 0.31 2.57e-7 Rheumatoid arthritis; CESC trans rs801193 1.000 rs4717319 chr7:66242593 A/G cg26939375 chr7:64535504 NA 0.66 9.1 0.49 2.19e-17 Aortic root size; CESC cis rs7927592 0.763 rs4340059 chr11:68362433 A/G cg16797656 chr11:68205561 LRP5 0.47 7.07 0.4 1.35e-11 Total body bone mineral density; CESC cis rs763014 0.931 rs62030903 chr16:638323 T/A cg00908189 chr16:619842 PIGQ 0.63 8.33 0.46 4.24e-15 Height; CESC cis rs2777491 0.915 rs28583065 chr15:41608470 T/C cg02330683 chr15:41787940 ITPKA 0.46 6.69 0.38 1.35e-10 Ulcerative colitis; CESC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg07677032 chr17:61819896 STRADA 0.41 5.17 0.3 4.59e-7 Height; CESC cis rs4481887 0.676 rs28684663 chr1:248548325 T/C cg26353448 chr1:248524236 OR2T4 -0.38 -5.61 -0.33 5.16e-8 Common traits (Other); CESC cis rs8017423 0.967 rs11159957 chr14:90715972 A/G cg14092571 chr14:90743983 NA 0.58 8.84 0.48 1.32e-16 Mortality in heart failure; CESC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg25036284 chr2:26402008 FAM59B -0.65 -7.73 -0.43 2.18e-13 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg19077165 chr18:44547161 KATNAL2 -0.53 -7.83 -0.43 1.17e-13 Personality dimensions; CESC cis rs11098499 0.863 rs34868248 chr4:120442430 A/G cg24375607 chr4:120327624 NA 0.43 5.24 0.31 3.36e-7 Corneal astigmatism; CESC cis rs3008870 0.959 rs2985810 chr1:67376162 T/C cg02640540 chr1:67518911 SLC35D1 0.49 5.21 0.3 3.81e-7 Lymphocyte percentage of white cells; CESC cis rs7512552 0.780 rs1260411 chr1:150382088 G/A cg15654264 chr1:150340011 RPRD2 0.4 5.3 0.31 2.45e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs6426558 0.537 rs498020 chr1:227304180 G/A cg10327440 chr1:227177885 CDC42BPA 0.47 5.84 0.34 1.48e-8 Neutrophil percentage of white cells; CESC cis rs7481584 0.624 rs413368 chr11:3047646 C/G cg08508325 chr11:3079039 CARS 0.29 5.08 0.3 7.06e-7 Calcium levels; CESC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg13206674 chr6:150067644 NUP43 0.4 5.39 0.31 1.57e-7 Lung cancer; CESC cis rs67311347 1.000 rs1466237 chr3:40462026 C/G cg09455208 chr3:40491958 NA 0.44 7.58 0.42 5.75e-13 Renal cell carcinoma; CESC cis rs17209837 0.607 rs45560338 chr7:87111106 T/C cg00919237 chr7:87102261 ABCB4 -0.49 -6.5 -0.37 4.02e-10 Gallbladder cancer; CESC cis rs7666738 0.830 rs6839203 chr4:98839814 C/G cg17366294 chr4:99064904 C4orf37 0.53 7.17 0.4 7.39e-12 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20845262 chr7:62514736 NA 0.38 6.26 0.36 1.57e-9 Fibrinogen levels; CESC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg18404041 chr3:52824283 ITIH1 0.47 7.99 0.44 4.19e-14 Bipolar disorder; CESC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg16049864 chr8:95962084 TP53INP1 -0.64 -11.08 -0.56 1.07e-23 Type 2 diabetes; CESC cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg26597838 chr10:835615 NA 0.86 9.15 0.49 1.61e-17 Eosinophil percentage of granulocytes; CESC cis rs116095464 0.558 rs10462755 chr5:246748 T/C cg20965017 chr5:231967 SDHA -0.48 -5.4 -0.31 1.47e-7 Breast cancer; CESC cis rs2012796 1.000 rs10450894 chr14:81825172 T/A cg02996355 chr14:81879375 NA 0.5 5.86 0.34 1.34e-8 Night sleep phenotypes; CESC cis rs6430585 0.759 rs12467770 chr2:136536095 G/A cg07169764 chr2:136633963 MCM6 1.28 16.93 0.72 4.28e-44 Corneal structure; CESC cis rs7100689 0.646 rs7077712 chr10:82134894 A/G cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 13.17 0.63 8.39e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6502050 0.865 rs56193110 chr17:80151501 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.43e-7 Life satisfaction; CESC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs7177699 0.557 rs55870734 chr15:79117917 A/T cg04896959 chr15:78267971 NA 0.32 5.04 0.3 8.54e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs7103648 0.669 rs7927445 chr11:47780754 G/T cg20307385 chr11:47447363 PSMC3 0.8 12.17 0.6 2.22e-27 Diastolic blood pressure;Systolic blood pressure; CESC cis rs116095464 0.558 rs10057674 chr5:266813 C/T cg22857025 chr5:266934 NA -1.3 -18.55 -0.75 8.05e-50 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16636271 chr6:139694487 CITED2 -0.46 -6.16 -0.35 2.65e-9 Ulcerative colitis; CESC cis rs7605827 0.866 rs7598936 chr2:15597289 A/G cg19274914 chr2:15703543 NA 0.33 5.91 0.34 1.04e-8 Educational attainment (years of education); CESC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg07308232 chr7:1071921 C7orf50 -0.54 -7.55 -0.42 7.14e-13 Longevity;Endometriosis; CESC cis rs262150 0.659 rs2730275 chr7:158793397 A/G cg19418458 chr7:158789849 NA -0.5 -8.0 -0.44 3.77e-14 Facial morphology (factor 20); CESC cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 6.08 0.35 4.17e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9443189 0.570 rs7755068 chr6:76405700 A/G cg01950844 chr6:76311363 SENP6 0.88 9.29 0.5 6.05e-18 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10078639 chr10:116286586 ABLIM1 0.55 6.51 0.37 3.8e-10 Gut microbiome composition (summer); CESC cis rs986417 0.901 rs10134736 chr14:60998540 A/T cg00859478 chr14:60978094 SIX6 0.47 5.06 0.3 7.87e-7 Gut microbiota (bacterial taxa); CESC cis rs9911578 1.000 rs8067571 chr17:56868856 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -6.87 -0.39 4.62e-11 Intelligence (multi-trait analysis); CESC cis rs12579753 0.917 rs12316644 chr12:82205497 C/T cg21193143 chr12:82153300 PPFIA2 0.33 5.1 0.3 6.43e-7 Resting heart rate; CESC cis rs8133932 0.654 rs2839050 chr21:47326666 G/A cg14185626 chr21:47401492 COL6A1 0.47 5.1 0.3 6.46e-7 Schizophrenia; CESC cis rs697003 0.966 rs701929 chr1:211846876 C/T cg26036067 chr1:211849175 NEK2 0.39 5.08 0.3 7.27e-7 Red cell distribution width; CESC cis rs654950 0.934 rs638859 chr1:42001444 A/G cg06885757 chr1:42089581 HIVEP3 0.63 10.13 0.53 1.33e-20 Airway imaging phenotypes; CESC cis rs4423214 0.879 rs12803256 chr11:71132868 A/G cg05163923 chr11:71159392 DHCR7 0.77 10.29 0.53 4.06e-21 Vitamin D levels; CESC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs9399135 0.967 rs4451151 chr6:135310546 C/T cg22676075 chr6:135203613 NA 0.52 7.27 0.41 3.94e-12 Red blood cell count; CESC cis rs34779708 0.733 rs7086715 chr10:35541840 A/G cg04310649 chr10:35416472 CREM -0.47 -5.39 -0.31 1.59e-7 Inflammatory bowel disease;Crohn's disease; CESC trans rs1814175 0.645 rs11040535 chr11:49808669 C/T cg03929089 chr4:120376271 NA -0.86 -13.34 -0.63 2.07e-31 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12049088 chr22:36784491 MYH9 -0.6 -7.25 -0.41 4.58e-12 Gut microbiome composition (summer); CESC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.87 14.33 0.66 7.18e-35 Menarche (age at onset); CESC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg06484146 chr7:12443880 VWDE -0.74 -8.94 -0.48 6.6e-17 Coronary artery disease; CESC trans rs1953600 0.715 rs1079242 chr10:81917708 C/T cg02976843 chr17:2843257 RAP1GAP2 -0.41 -6.64 -0.38 1.81e-10 Sarcoidosis; CESC trans rs12541635 0.833 rs4099936 chr8:107099297 G/A cg19509715 chr3:44037128 NA -0.37 -6.02 -0.35 5.82e-9 Age of smoking initiation; CESC trans rs2727020 0.615 rs10128582 chr11:49447424 C/T cg15704280 chr7:45808275 SEPT13 -0.9 -15.46 -0.69 7.41e-39 Coronary artery disease; CESC cis rs9457247 1.000 rs430293 chr6:167404958 A/G cg07741184 chr6:167504864 NA 0.28 5.1 0.3 6.54e-7 Crohn's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg00521551 chr11:64646313 EHD1 0.56 7.26 0.41 4.2e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs66573146 0.572 rs68169399 chr4:6952491 T/A cg07817883 chr1:32538562 TMEM39B 1.19 8.25 0.45 7.66e-15 Granulocyte percentage of myeloid white cells; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg15806109 chr3:125802485 SLC41A3 -0.46 -6.08 -0.35 4.24e-9 Height; CESC cis rs11252926 0.574 rs7068976 chr10:453112 A/G cg18196295 chr10:418757 DIP2C 0.54 7.3 0.41 3.33e-12 Psychosis in Alzheimer's disease; CESC cis rs4689388 0.890 rs4342257 chr4:6290037 G/C cg14416269 chr4:6271139 WFS1 0.46 7.84 0.43 1.13e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10314295 chr10:75936245 ADK 0.51 6.71 0.38 1.16e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg03452623 chr4:187889614 NA -0.94 -19.16 -0.76 6.22e-52 Lobe attachment (rater-scored or self-reported); CESC cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC trans rs10500991 0.737 rs59125323 chr11:24882489 T/C cg07129253 chr8:30890560 PURG;WRN -0.54 -6.73 -0.38 1.05e-10 Iron status biomarkers; CESC cis rs7937682 0.889 rs1940529 chr11:111498523 G/C cg09085632 chr11:111637200 PPP2R1B -1.01 -15.97 -0.7 1.14e-40 Primary sclerosing cholangitis; CESC cis rs2637266 0.703 rs846578 chr10:78499508 T/G cg18941641 chr10:78392320 NA 0.4 7.58 0.42 5.69e-13 Pulmonary function; CESC cis rs11098499 0.863 rs13149407 chr4:120437825 A/G cg09307838 chr4:120376055 NA 0.93 12.69 0.61 3.78e-29 Corneal astigmatism; CESC cis rs1215050 0.704 rs783915 chr4:99023151 C/G cg05340658 chr4:99064831 C4orf37 0.58 7.82 0.43 1.27e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs73019876 0.869 rs2522094 chr19:22125569 A/G cg11619707 chr19:22235551 ZNF257 -0.29 -5.46 -0.32 1.07e-7 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.24e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7086627 0.515 rs10887895 chr10:82210011 A/G cg03267442 chr10:82210566 NA -0.34 -5.6 -0.33 5.45e-8 Post bronchodilator FEV1; CESC cis rs12478296 0.892 rs11893879 chr2:243010411 G/A cg06360820 chr2:242988706 NA -0.72 -9.14 -0.49 1.74e-17 Obesity-related traits; CESC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg12311346 chr5:56204834 C5orf35 -0.42 -5.26 -0.31 2.99e-7 Coronary artery disease; CESC cis rs17023223 0.537 rs12064033 chr1:119709558 G/A cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs11648796 0.765 rs2003832 chr16:769538 G/A cg00802000 chr16:706648 WDR90 -0.47 -5.75 -0.33 2.48e-8 Height; CESC cis rs3020736 0.500 rs6519306 chr22:42501217 T/C cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07667977 chr2:32236247 MEMO1 -0.65 -7.75 -0.43 1.97e-13 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06659889 chr3:12599050 MKRN2 0.53 6.87 0.39 4.46e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2732480 0.557 rs2732441 chr12:48723324 C/G cg04545296 chr12:48745243 ZNF641 0.43 7.3 0.41 3.34e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7119 0.717 rs11629652 chr15:77779951 C/A cg17802220 chr15:77601643 NA -0.51 -7.18 -0.4 7.24e-12 Type 2 diabetes; CESC trans rs7937682 0.889 rs7948236 chr11:111499933 C/A cg18187862 chr3:45730750 SACM1L 0.51 6.48 0.37 4.4e-10 Primary sclerosing cholangitis; CESC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg14926445 chr8:58193284 C8orf71 -0.53 -5.61 -0.33 5.1e-8 Developmental language disorder (linguistic errors); CESC cis rs7605827 0.930 rs2380649 chr2:15532612 A/C cg19274914 chr2:15703543 NA 0.35 6.39 0.37 7.22e-10 Educational attainment (years of education); CESC trans rs6828577 0.862 rs298974 chr4:119636034 A/G cg05098011 chr1:151736092 OAZ3;MRPL9 0.48 6.02 0.35 5.93e-9 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs2204008 0.754 rs11514074 chr12:38401128 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.72 0.55 1.66e-22 Bladder cancer; CESC cis rs1797081 0.840 rs10904820 chr10:16848473 A/G cg23933602 chr10:16859644 RSU1 1.07 20.8 0.79 1.24e-57 Platelet distribution width; CESC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7044106 0.762 rs13291660 chr9:123392748 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.78 11.76 0.59 5.52e-26 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06363516 chr2:241530274 CAPN10 -0.62 -7.72 -0.43 2.36e-13 Gut microbiome composition (summer); CESC cis rs6963495 0.818 rs118134111 chr7:105161229 A/C cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs9309473 1.000 rs6707722 chr2:73654363 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.2 -0.36 2.19e-9 Metabolite levels; CESC cis rs7107174 1.000 rs2510037 chr11:77966099 A/G cg02023728 chr11:77925099 USP35 0.41 6.0 0.35 6.28e-9 Testicular germ cell tumor; CESC cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg05234568 chr11:5960015 NA -0.55 -6.36 -0.36 8.79e-10 DNA methylation (variation); CESC cis rs1707322 0.752 rs6678444 chr1:46229847 A/G cg06784218 chr1:46089804 CCDC17 0.39 6.87 0.39 4.55e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.73 0.38 1.02e-10 Prudent dietary pattern; CESC cis rs1707322 1.000 rs785497 chr1:46591903 G/C cg06784218 chr1:46089804 CCDC17 -0.36 -5.93 -0.34 9.35e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs742614 0.576 rs2747537 chr20:32405217 A/G cg06304546 chr20:32448765 NA -0.4 -5.09 -0.3 6.9e-7 Stearic acid (18:0) levels; CESC trans rs6445797 0.589 rs11715395 chr3:56681949 G/A cg15444621 chr13:113611794 NA 0.34 6.07 0.35 4.3e-9 Gastritis; CESC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg25427524 chr10:38739819 LOC399744 -0.69 -10.25 -0.53 5.52e-21 Extrinsic epigenetic age acceleration; CESC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg01988459 chr11:68622903 NA -0.42 -5.79 -0.34 1.99e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs643506 0.874 rs4936786 chr11:111727227 C/T cg09085632 chr11:111637200 PPP2R1B 0.4 5.21 0.31 3.71e-7 Breast cancer; CESC cis rs5769765 0.773 rs6520065 chr22:50294470 A/T cg26441486 chr22:50317300 CRELD2 0.39 5.41 0.32 1.4e-7 Schizophrenia; CESC cis rs6772849 1.000 rs6772849 chr3:128306418 T/C cg16766828 chr3:128327626 NA -0.31 -5.06 -0.3 7.77e-7 Monocyte percentage of white cells;Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20455436 chr19:55994860 ZNF628 -0.54 -6.05 -0.35 4.85e-9 Gut microbiome composition (summer); CESC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg14893161 chr1:205819251 PM20D1 0.87 15.37 0.69 1.47e-38 Menarche (age at onset); CESC cis rs796364 0.806 rs112486506 chr2:201073947 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -5.95 -0.34 8.33e-9 Schizophrenia; CESC cis rs1499972 0.648 rs57945129 chr3:117641724 C/T cg07612923 chr3:117604196 NA 0.66 5.98 0.34 7.1e-9 Schizophrenia; CESC cis rs2243480 0.803 rs36127118 chr7:65565505 A/G cg13147721 chr7:65941812 NA -0.94 -8.87 -0.48 1.1e-16 Diabetic kidney disease; CESC cis rs7103648 0.669 rs11039332 chr11:47695840 G/A cg20307385 chr11:47447363 PSMC3 0.82 12.4 0.61 3.87e-28 Diastolic blood pressure;Systolic blood pressure; CESC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.65 0.47 4.88e-16 Menopause (age at onset); CESC cis rs6460942 0.597 rs10273045 chr7:12519371 T/C cg02935154 chr7:12443704 VWDE -0.48 -5.09 -0.3 6.85e-7 Coronary artery disease; CESC cis rs898097 0.625 rs2125479 chr17:80890262 A/G cg15664640 chr17:80829946 TBCD -0.45 -6.14 -0.35 2.96e-9 Breast cancer; CESC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg22143856 chr6:28129313 ZNF389 0.38 5.26 0.31 3.01e-7 Cardiac Troponin-T levels; CESC cis rs6061231 0.740 rs11698650 chr20:60958374 A/T cg22541963 chr20:60982533 CABLES2 0.42 5.33 0.31 2.12e-7 Colorectal cancer; CESC cis rs5769765 1.000 rs8138941 chr22:50290678 G/A cg02269571 chr22:50332266 NA -0.45 -6.07 -0.35 4.4e-9 Schizophrenia; CESC cis rs10887741 0.624 rs7088341 chr10:89427820 C/T cg13926569 chr10:89418898 PAPSS2 0.42 6.63 0.38 1.91e-10 Exercise (leisure time); CESC trans rs561341 0.739 rs7213369 chr17:30211878 G/A cg20587970 chr11:113659929 NA 0.59 7.5 0.42 9.74e-13 Hip circumference adjusted for BMI; CESC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg07648498 chr16:89883185 FANCA 0.43 5.46 0.32 1.1e-7 Vitiligo; CESC cis rs9457247 0.565 rs12193698 chr6:167512073 C/A cg07741184 chr6:167504864 NA 0.43 7.65 0.43 3.84e-13 Crohn's disease; CESC cis rs17376456 0.569 rs7702348 chr5:93065683 A/G cg25358565 chr5:93447407 FAM172A -0.5 -5.79 -0.34 1.94e-8 Diabetic retinopathy; CESC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg06634786 chr22:41940651 POLR3H 0.68 6.72 0.38 1.13e-10 Vitiligo; CESC cis rs2479106 0.963 rs1627536 chr9:126542704 A/T cg16191174 chr9:126692580 DENND1A -0.5 -6.87 -0.39 4.56e-11 Polycystic ovary syndrome; CESC cis rs2204008 0.837 rs11495548 chr12:38076756 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs7191700 0.583 rs243314 chr16:11385104 G/C cg00044050 chr16:11439710 C16orf75 0.44 5.23 0.31 3.46e-7 Multiple sclerosis; CESC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.19 -0.3 4.23e-7 Obesity-related traits; CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg07157834 chr1:205819609 PM20D1 0.81 13.02 0.62 2.83e-30 Menarche (age at onset); CESC cis rs2303759 0.543 rs7255778 chr19:49906608 G/A cg22590775 chr19:49891494 CCDC155 0.52 6.13 0.35 3.15e-9 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26422674 chr12:10766150 MAGOHB 0.59 7.18 0.4 6.84e-12 Gut microbiome composition (summer); CESC cis rs2120019 0.938 rs2304903 chr15:75315778 A/G cg09165964 chr15:75287851 SCAMP5 -0.81 -9.93 -0.52 5.63e-20 Blood trace element (Zn levels); CESC cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg23711669 chr6:146136114 FBXO30 0.97 14.47 0.66 2.25e-35 Lobe attachment (rater-scored or self-reported); CESC trans rs747782 0.582 rs7949865 chr11:48346202 A/C cg15704280 chr7:45808275 SEPT13 -0.66 -6.17 -0.35 2.52e-9 Intraocular pressure; CESC cis rs9908102 0.740 rs2286336 chr17:12915941 C/T cg26162695 chr17:12921313 ELAC2 -0.55 -6.03 -0.35 5.49e-9 Schizophrenia; CESC cis rs60871478 0.787 rs4720928 chr7:808002 T/C cg05535760 chr7:792225 HEATR2 0.87 10.78 0.55 1.07e-22 Cerebrospinal P-tau181p levels; CESC cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg17366294 chr4:99064904 C4orf37 0.58 8.28 0.45 6.25e-15 Colonoscopy-negative controls vs population controls; CESC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg17372223 chr3:52568218 NT5DC2 0.44 6.55 0.37 3e-10 Bipolar disorder; CESC cis rs524023 0.914 rs2277311 chr11:64387932 G/A cg07220939 chr11:64358617 SLC22A12 -0.36 -5.45 -0.32 1.17e-7 Urate levels in obese individuals; CESC cis rs7084402 0.967 rs7087998 chr10:60271531 A/G cg07615347 chr10:60278583 BICC1 -0.57 -8.63 -0.47 5.58e-16 Refractive error; CESC cis rs2249625 0.874 rs2496509 chr6:72893667 C/A cg18830697 chr6:72922368 RIMS1 -0.37 -5.31 -0.31 2.35e-7 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs6964587 1.000 rs7802788 chr7:91736874 A/G cg17063962 chr7:91808500 NA 0.54 7.46 0.42 1.24e-12 Breast cancer; CESC cis rs6912958 0.559 rs183599 chr6:88061024 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.92 0.56 3.53e-23 Monocyte percentage of white cells; CESC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg24642844 chr7:1081250 C7orf50 -0.75 -9.03 -0.49 3.61e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg23803603 chr1:2058230 PRKCZ -0.37 -6.78 -0.38 8.01e-11 Height; CESC cis rs30380 0.587 rs30185 chr5:96125465 G/A cg16492584 chr5:96139282 ERAP1 -0.47 -6.63 -0.38 1.89e-10 Cerebrospinal fluid biomarker levels; CESC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.78 10.75 0.55 1.31e-22 Prudent dietary pattern; CESC cis rs11264213 0.901 rs74879824 chr1:36413117 T/A cg27506609 chr1:36549197 TEKT2 0.67 5.54 0.32 7.16e-8 Schizophrenia; CESC cis rs7568458 0.684 rs67988001 chr2:85787123 C/T cg02493740 chr2:85810744 VAMP5 -0.57 -8.37 -0.46 3.29e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.51 -7.53 -0.42 8.18e-13 Electroencephalogram traits; CESC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg27125505 chr17:43679177 LOC644172 0.51 6.75 0.38 9.27e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7044106 0.708 rs2416760 chr9:123374639 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.72 10.65 0.55 2.8e-22 Hip circumference adjusted for BMI; CESC cis rs8017423 0.647 rs12590712 chr14:90822481 T/C cg14092571 chr14:90743983 NA 0.44 6.77 0.38 8.12e-11 Mortality in heart failure; CESC cis rs9837602 0.745 rs792834 chr3:99476121 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.44 -5.65 -0.33 4.12e-8 Breast cancer; CESC cis rs2276314 1.000 rs2298716 chr18:33552598 C/T cg19628046 chr18:33552617 C18orf21 0.6 6.79 0.38 7.47e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs713587 0.713 rs11682135 chr2:25205377 G/A cg01884057 chr2:25150051 NA -0.37 -6.94 -0.39 2.96e-11 Body mass index in non-asthmatics; CESC cis rs12586317 0.547 rs2273154 chr14:35433187 C/T cg16230307 chr14:35515116 FAM177A1 0.97 10.42 0.54 1.61e-21 Psoriasis; CESC cis rs9902453 1.000 rs4575590 chr17:28361969 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.11e-13 Coffee consumption (cups per day); CESC cis rs7084402 1.000 rs1427202 chr10:60267917 A/T cg07615347 chr10:60278583 BICC1 -0.6 -9.2 -0.49 1.08e-17 Refractive error; CESC cis rs2479106 0.963 rs7850870 chr9:126509996 C/T cg16191174 chr9:126692580 DENND1A 0.47 6.44 0.37 5.5e-10 Polycystic ovary syndrome; CESC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg11987759 chr7:65425863 GUSB 0.48 6.62 0.38 1.97e-10 Corneal structure; CESC cis rs4594175 0.962 rs8008182 chr14:51608357 C/T cg23942311 chr14:51606299 NA 0.39 5.96 0.34 8.22e-9 Cancer; CESC cis rs2455799 0.573 rs2255248 chr3:15754849 A/G cg16303742 chr3:15540471 COLQ 0.37 5.8 0.34 1.9e-8 Mean platelet volume; CESC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.79 0.33 2.03e-8 Menopause (age at onset); CESC trans rs3087243 0.755 rs231733 chr2:204694465 A/G cg01841312 chr10:38069945 NA 0.39 6.44 0.37 5.64e-10 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs9611565 0.546 rs34077262 chr22:42061639 A/G cg06634786 chr22:41940651 POLR3H 0.54 5.67 0.33 3.81e-8 Vitiligo; CESC cis rs10189230 0.967 rs13026659 chr2:222353014 C/T cg14652038 chr2:222343519 EPHA4 0.36 7.67 0.43 3.21e-13 Urate levels in lean individuals; CESC cis rs9911578 0.935 rs7216698 chr17:57007495 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.38 5.04 0.3 8.69e-7 Intelligence (multi-trait analysis); CESC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -6.71 -0.38 1.19e-10 Bipolar disorder; CESC cis rs116095464 0.510 rs73016876 chr5:244475 T/C cg10591111 chr5:226296 SDHA -0.52 -6.31 -0.36 1.17e-9 Breast cancer; CESC cis rs12042107 0.740 rs7548936 chr1:91207757 C/G cg13456504 chr1:91191583 NA -0.3 -5.16 -0.3 4.8e-7 Educational attainment; CESC cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9811920 0.809 rs35422475 chr3:99711545 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.43 -5.67 -0.33 3.72e-8 Axial length; CESC cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg12373951 chr3:133503437 NA -0.36 -5.04 -0.3 8.45e-7 Iron status biomarkers; CESC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg23018236 chr17:30244563 NA -0.41 -5.08 -0.3 7.12e-7 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.54 0.37 3.16e-10 Prudent dietary pattern; CESC cis rs2963155 0.518 rs72801090 chr5:142774692 C/T cg17617527 chr5:142782415 NR3C1 0.84 7.59 0.42 5.45e-13 Breast cancer; CESC cis rs17818399 0.712 rs13008088 chr2:46781580 C/G cg02822958 chr2:46747628 ATP6V1E2 0.42 5.34 0.31 1.99e-7 Height; CESC cis rs9457247 1.000 rs400176 chr6:167406238 T/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.54 -0.46 1.09e-15 Crohn's disease; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg04234412 chr22:24373322 LOC391322 -0.64 -9.39 -0.5 2.83e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs34779708 0.897 rs9787566 chr10:35279455 T/A cg04310649 chr10:35416472 CREM -0.5 -5.97 -0.34 7.61e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs10791323 0.627 rs2723614 chr11:133705871 T/G cg15485101 chr11:133734466 NA 0.41 6.54 0.37 3.11e-10 Childhood ear infection; CESC cis rs9399135 0.684 rs1135205 chr6:135281795 C/T cg22676075 chr6:135203613 NA 0.48 6.59 0.38 2.37e-10 Red blood cell count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.12.2922115F chr12:133248407 POLE -0.56 -7.42 -0.41 1.62e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg14829155 chr15:31115871 NA -0.76 -10.62 -0.55 3.5e-22 Huntington's disease progression; CESC cis rs6754311 0.773 rs188680 chr2:136630989 A/G cg07169764 chr2:136633963 MCM6 -0.7 -8.51 -0.46 1.28e-15 Mosquito bite size; CESC cis rs6460942 1.000 rs7796485 chr7:12405676 G/A cg20607287 chr7:12443886 VWDE -0.79 -8.72 -0.47 3.1e-16 Coronary artery disease; CESC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg18301423 chr5:131593218 PDLIM4 0.38 5.49 0.32 9.57e-8 Acylcarnitine levels; CESC cis rs12142240 0.698 rs72677596 chr1:46833930 C/T cg00530320 chr1:46809349 NSUN4 0.63 8.16 0.45 1.33e-14 Menopause (age at onset); CESC cis rs7678296 1.000 rs59175692 chr4:37195539 C/T cg06805348 chr4:37245195 KIAA1239 0.45 5.12 0.3 5.74e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14420186 chr9:91926487 CKS2 0.62 7.11 0.4 1.1e-11 Gut microbiome composition (summer); CESC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg08968635 chr6:28129556 ZNF389 -0.39 -5.22 -0.31 3.69e-7 Parkinson's disease; CESC cis rs151234 0.676 rs231970 chr16:28567004 A/G cg01378222 chr16:28622494 SULT1A1 -0.56 -7.05 -0.4 1.57e-11 Platelet distribution width; CESC cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg05283184 chr6:79620031 NA -0.42 -6.46 -0.37 5.06e-10 Intelligence (multi-trait analysis); CESC cis rs9309473 0.632 rs6706179 chr2:73578577 C/T cg20560298 chr2:73613845 ALMS1 -0.45 -6.09 -0.35 3.94e-9 Metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21155778 chr12:95611301 FGD6;VEZT -0.45 -6.11 -0.35 3.53e-9 Fibrinogen levels; CESC cis rs1941023 0.606 rs7926219 chr11:60180335 C/T cg08716584 chr11:60157161 MS4A7 -0.43 -6.34 -0.36 1.01e-9 Congenital heart disease (maternal effect); CESC cis rs2710642 0.611 rs6706506 chr2:62861824 T/C cg17519650 chr2:63277830 OTX1 0.47 5.54 0.32 7.36e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs6964587 1.000 rs12539231 chr7:91634963 G/A cg17063962 chr7:91808500 NA 0.58 8.01 0.44 3.65e-14 Breast cancer; CESC cis rs11792861 0.816 rs72607157 chr9:111748001 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 6.67 0.38 1.46e-10 Menarche (age at onset); CESC cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg09365446 chr1:150670422 GOLPH3L 0.41 5.38 0.31 1.67e-7 Melanoma; CESC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs9815354 0.638 rs113712591 chr3:42050624 C/T cg03022575 chr3:42003672 ULK4 0.76 6.71 0.38 1.21e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs17376456 0.877 rs10059630 chr5:93459807 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.44 0.32 1.23e-7 Diabetic retinopathy; CESC cis rs9346455 0.614 rs9294899 chr6:72016302 G/T cg27238071 chr6:71998145 OGFRL1 0.64 6.17 0.35 2.52e-9 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs7666738 0.791 rs1426674 chr4:98924247 C/A cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg25517755 chr10:38738941 LOC399744 -0.47 -6.01 -0.35 6.02e-9 Extrinsic epigenetic age acceleration; CESC cis rs660899 0.588 rs37470 chr1:44277948 G/C cg11704212 chr1:44303111 ST3GAL3 -0.38 -5.07 -0.3 7.46e-7 Hypertension risk in short sleep duration; CESC cis rs9611565 0.512 rs132784 chr22:42052363 G/A cg17376030 chr22:41985996 PMM1 -0.79 -8.79 -0.48 1.94e-16 Vitiligo; CESC cis rs4481887 1.000 rs10888352 chr1:248451965 G/A cg00666640 chr1:248458726 OR2T12 0.41 6.72 0.38 1.09e-10 Common traits (Other); CESC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg10691866 chr7:65817282 TPST1 0.31 5.32 0.31 2.24e-7 Aortic root size; CESC cis rs1042058 0.565 rs650110 chr10:30753132 A/G cg25182066 chr10:30743637 MAP3K8 -0.52 -7.26 -0.41 4.3e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg12756686 chr19:29218302 NA 0.58 7.52 0.42 8.38e-13 Methadone dose in opioid dependence; CESC cis rs9902453 1.000 rs62070312 chr17:28438877 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 8.09 0.45 2.1e-14 Coffee consumption (cups per day); CESC cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg05343316 chr1:45956843 TESK2 -0.51 -6.57 -0.37 2.7e-10 High light scatter reticulocyte count; CESC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg18876405 chr7:65276391 NA -0.46 -6.2 -0.36 2.13e-9 Aortic root size; CESC cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg18225595 chr11:63971243 STIP1 0.72 9.78 0.52 1.71e-19 Platelet count; CESC cis rs3820068 0.603 rs6668726 chr1:15962614 G/A cg13390004 chr1:15929781 NA 0.37 5.89 0.34 1.18e-8 Systolic blood pressure; CESC cis rs826838 0.874 rs11183816 chr12:38834656 T/G cg26384229 chr12:38710491 ALG10B 0.83 14.57 0.67 1.05e-35 Heart rate; CESC cis rs9911578 0.874 rs302865 chr17:56756977 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.16 0.3 4.9e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01057248 chr19:2887520 NA -0.51 -6.09 -0.35 3.86e-9 Gut microbiome composition (summer); CESC cis rs7044106 0.762 rs1886337 chr9:123443776 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.83 0.34 1.58e-8 Hip circumference adjusted for BMI; CESC cis rs854765 0.964 rs854762 chr17:18009102 G/A cg09796270 chr17:17721594 SREBF1 -0.4 -5.35 -0.31 1.94e-7 Total body bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14474966 chr17:77808999 CBX4 0.45 6.51 0.37 3.68e-10 Gut microbiota (bacterial taxa); CESC cis rs2228479 0.850 rs62052212 chr16:89981960 G/A cg04013166 chr16:89971882 TCF25 0.77 6.5 0.37 4.07e-10 Skin colour saturation; CESC cis rs9457247 0.765 rs9457259 chr6:167444281 C/T cg07741184 chr6:167504864 NA 0.35 6.32 0.36 1.11e-9 Crohn's disease; CESC cis rs920590 0.758 rs1826420 chr8:19664878 G/T cg17834443 chr8:19674713 INTS10 0.58 6.73 0.38 1.07e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs6540556 0.723 rs12059226 chr1:209906675 A/G cg05527609 chr1:210001259 C1orf107 -0.65 -7.38 -0.41 2.1e-12 Red blood cell count; CESC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg17372223 chr3:52568218 NT5DC2 0.4 5.93 0.34 9.47e-9 Electroencephalogram traits; CESC cis rs939574 0.790 rs72955447 chr2:220098287 G/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.88 7.4 0.41 1.81e-12 Platelet distribution width; CESC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg02569458 chr12:86230093 RASSF9 0.49 7.22 0.41 5.67e-12 Major depressive disorder; CESC cis rs3749237 0.595 rs3870337 chr3:49557095 G/T cg02487422 chr3:49467188 NICN1 0.56 8.28 0.45 6.25e-15 Resting heart rate; CESC cis rs3733585 0.699 rs13328050 chr4:9951120 G/T cg00071950 chr4:10020882 SLC2A9 -0.68 -10.81 -0.55 8.56e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8072100 0.817 rs12449647 chr17:45548958 C/A cg25173405 chr17:45401733 C17orf57 -0.47 -6.16 -0.35 2.71e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7937682 0.889 rs1789359 chr11:111475995 T/A cg09085632 chr11:111637200 PPP2R1B -0.95 -14.72 -0.67 3.09e-36 Primary sclerosing cholangitis; CESC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg11644478 chr21:40555479 PSMG1 1.02 16.67 0.72 3.53e-43 Cognitive function; CESC cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg19418458 chr7:158789849 NA -0.48 -8.08 -0.44 2.31e-14 Facial morphology (factor 20); CESC cis rs3750965 0.920 rs10896420 chr11:68863047 G/A cg01403660 chr11:68851641 TPCN2 0.4 5.48 0.32 9.89e-8 Hair color; CESC cis rs72945132 0.882 rs55915603 chr11:70210067 G/T cg00319359 chr11:70116639 PPFIA1 0.78 7.27 0.41 3.99e-12 Coronary artery disease; CESC cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.1e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 7.87 0.44 8.99e-14 Menopause (age at onset); CESC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg17372223 chr3:52568218 NT5DC2 0.36 5.11 0.3 6.16e-7 Bipolar disorder; CESC cis rs17253792 0.822 rs17253730 chr14:56157911 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.73 0.33 2.74e-8 Putamen volume; CESC cis rs796364 0.806 rs1605900 chr2:200870197 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 7.68 0.43 3.06e-13 Schizophrenia; CESC cis rs1707322 0.650 rs4660879 chr1:46105401 C/A cg06784218 chr1:46089804 CCDC17 0.41 7.31 0.41 3.1e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14094460 chr4:43900946 NA -0.54 -7.39 -0.41 1.92e-12 Gut microbiome composition (summer); CESC cis rs11864453 0.578 rs2072141 chr16:72133211 G/A cg01557791 chr16:72042693 DHODH -0.43 -5.66 -0.33 3.85e-8 Fibrinogen levels; CESC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg13114125 chr14:105738426 BRF1 0.76 9.66 0.51 4.03e-19 Mean platelet volume;Platelet distribution width; CESC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg25036284 chr2:26402008 FAM59B -0.71 -7.95 -0.44 5.27e-14 Gut microbiome composition (summer); CESC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.52 -0.37 3.62e-10 Bipolar disorder; CESC cis rs9611565 0.694 rs202613 chr22:41821993 C/A cg03806693 chr22:41940476 POLR3H 1.2 14.5 0.67 1.86e-35 Vitiligo; CESC cis rs1443512 0.812 rs1975472 chr12:54337083 A/G cg12374095 chr12:54320830 NA -0.45 -6.24 -0.36 1.69e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs1153858 1.000 rs7402650 chr15:45701895 C/T cg21132104 chr15:45694354 SPATA5L1 0.86 11.69 0.58 9.6e-26 Homoarginine levels; CESC cis rs1005277 0.529 rs1780125 chr10:38531376 A/G cg00409905 chr10:38381863 ZNF37A -0.51 -6.84 -0.39 5.62e-11 Extrinsic epigenetic age acceleration; CESC cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg07636037 chr3:49044803 WDR6 1.03 19.55 0.77 2.54e-53 Parkinson's disease; CESC cis rs796364 0.813 rs7565417 chr2:201057491 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.11 0.35 3.55e-9 Schizophrenia; CESC cis rs4566357 0.930 rs12621916 chr2:227923564 T/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.28 -0.31 2.76e-7 Coronary artery disease; CESC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg18252515 chr7:66147081 NA -0.42 -5.42 -0.32 1.35e-7 Aortic root size; CESC cis rs722599 0.599 rs3825708 chr14:75200697 C/T cg11812906 chr14:75593930 NEK9 0.43 5.19 0.3 4.19e-7 IgG glycosylation; CESC cis rs3813567 0.702 rs7164665 chr15:78953919 T/C cg24631222 chr15:78858424 CHRNA5 0.48 5.19 0.3 4.27e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs362272 0.524 rs13150241 chr4:3367281 A/G cg14583973 chr4:3374767 RGS12 0.31 5.49 0.32 9.61e-8 Serum sulfate level; CESC cis rs9303401 0.614 rs68100606 chr17:56500898 G/A cg25039879 chr17:56429692 SUPT4H1 0.53 5.47 0.32 1.05e-7 Cognitive test performance; CESC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg07936489 chr17:37558343 FBXL20 0.81 11.81 0.59 3.83e-26 Glomerular filtration rate (creatinine); CESC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg03388025 chr16:89894329 SPIRE2 0.43 8.17 0.45 1.27e-14 Vitiligo; CESC cis rs2243480 1.000 rs35432774 chr7:65393019 G/C cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC cis rs1006703 0.544 rs8082265 chr17:3838761 C/T cg06463185 chr17:3833770 ATP2A3 -0.64 -6.26 -0.36 1.58e-9 Glucose homeostasis traits; CESC cis rs4722166 0.695 rs4722177 chr7:22798531 T/C cg13104385 chr7:22767384 IL6 0.39 5.69 0.33 3.41e-8 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09299076 chr16:89795781 ZNF276 -0.52 -6.04 -0.35 5.3300000000000004e-09 Gut microbiome composition (summer); CESC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg21433313 chr16:3507492 NAT15 0.66 8.34 0.46 4.08e-15 Tuberculosis; CESC cis rs7546094 0.967 rs910697 chr1:113063125 A/G cg22162597 chr1:113214053 CAPZA1 0.39 6.15 0.35 2.82e-9 Platelet distribution width; CESC cis rs113835537 0.529 rs4930379 chr11:66255674 G/A cg22134325 chr11:66188745 NPAS4 0.35 5.48 0.32 1.01e-7 Airway imaging phenotypes; CESC cis rs1215050 0.791 rs2123099 chr4:98803456 A/G cg05340658 chr4:99064831 C4orf37 0.52 6.88 0.39 4.36e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1707322 0.963 rs11211238 chr1:46449415 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2243480 0.901 rs35823062 chr7:65965821 A/G cg13147721 chr7:65941812 NA -0.94 -8.87 -0.48 1.09e-16 Diabetic kidney disease; CESC cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg05340658 chr4:99064831 C4orf37 0.78 11.82 0.59 3.43e-26 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02464656 chr6:44214659 HSP90AB1 -0.63 -7.57 -0.42 6.36e-13 Gut microbiome composition (summer); CESC trans rs637571 0.522 rs528736 chr11:65705108 A/G cg17712092 chr4:129076599 LARP1B 0.75 10.26 0.53 5.18e-21 Eosinophil percentage of white cells; CESC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg27125505 chr17:43679177 LOC644172 0.51 6.58 0.37 2.46e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg17158414 chr2:27665306 KRTCAP3 -0.28 -5.11 -0.3 6.26e-7 Total body bone mineral density; CESC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg05564831 chr3:52568323 NT5DC2 -0.47 -7.29 -0.41 3.47e-12 Electroencephalogram traits; CESC cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg22875332 chr1:76189707 ACADM 0.71 9.71 0.51 2.96e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg11644478 chr21:40555479 PSMG1 -0.83 -12.81 -0.62 1.5e-29 Cognitive function; CESC cis rs1348850 0.632 rs12616288 chr2:178503813 G/T cg23306229 chr2:178417860 TTC30B 0.59 7.3 0.41 3.35e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11785400 0.793 rs10956992 chr8:143736235 A/C cg10596483 chr8:143751796 JRK 0.42 5.37 0.31 1.69e-7 Schizophrenia; CESC cis rs10479542 0.503 rs12719865 chr5:178993566 C/T cg14820908 chr5:178986412 RUFY1 0.51 7.76 0.43 1.85e-13 Lung cancer; CESC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs9818758 0.556 rs11716614 chr3:49017208 C/G cg00383909 chr3:49044727 WDR6 0.98 5.88 0.34 1.21e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs11098499 0.909 rs6842762 chr4:120398236 A/T cg09307838 chr4:120376055 NA 0.92 13.12 0.63 1.21e-30 Corneal astigmatism; CESC cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg17366294 chr4:99064904 C4orf37 0.62 8.8 0.48 1.82e-16 Colonoscopy-negative controls vs population controls; CESC cis rs12208915 0.559 rs4706738 chr6:79514153 A/G cg05283184 chr6:79620031 NA 0.37 5.16 0.3 4.95e-7 Left atrial antero-posterior diameter; CESC cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg01579765 chr21:45077557 HSF2BP -0.54 -9.39 -0.5 2.98e-18 Mean corpuscular volume; CESC cis rs11638352 1.000 rs2412850 chr15:44278161 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.63 -5.6 -0.33 5.48e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs9457247 0.602 rs4710175 chr6:167467800 A/G cg23791538 chr6:167370224 RNASET2 -0.55 -7.27 -0.41 3.96e-12 Crohn's disease; CESC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg17971929 chr21:40555470 PSMG1 1.05 16.66 0.72 4.09e-43 Cognitive function; CESC cis rs9300255 0.739 rs2337934 chr12:123745359 A/G cg19016782 chr12:123741754 C12orf65 -0.5 -7.24 -0.41 4.92e-12 Neutrophil percentage of white cells; CESC cis rs3820068 0.705 rs72643701 chr1:15866219 G/A cg17385448 chr1:15911702 AGMAT 0.37 5.91 0.34 1.03e-8 Systolic blood pressure; CESC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg08859206 chr1:53392774 SCP2 -0.56 -7.34 -0.41 2.69e-12 Monocyte count; CESC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg27170947 chr2:26402098 FAM59B 0.87 9.85 0.52 1.01e-19 Gut microbiome composition (summer); CESC cis rs2046867 0.661 rs7637050 chr3:72910790 A/C cg25664220 chr3:72788482 NA -0.35 -5.23 -0.31 3.37e-7 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs17431357 1.000 rs73225238 chr12:120967488 G/A cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs881375 0.967 rs7034653 chr9:123687372 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 5.24 0.31 3.22e-7 Rheumatoid arthritis; CESC cis rs6088590 1.000 rs6119524 chr20:33373813 C/T cg06115741 chr20:33292138 TP53INP2 0.59 7.31 0.41 3.17e-12 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14223017 chr19:2151266 AP3D1 -0.48 -6.83 -0.39 5.68e-11 Fibrinogen levels; CESC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC cis rs2243480 1.000 rs1701750 chr7:65467145 T/C cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs9300255 0.596 rs10734900 chr12:123743445 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.03 -0.3 9.21e-7 Neutrophil percentage of white cells; CESC cis rs9303401 1.000 rs7218362 chr17:56888299 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.72 9.43 0.5 2.21e-18 Cognitive test performance; CESC cis rs3026101 0.671 rs56113612 chr17:5297761 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs7267979 1.000 rs2259928 chr20:25281834 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg21433313 chr16:3507492 NAT15 0.66 7.1 0.4 1.16e-11 Tuberculosis; CESC cis rs17854409 0.881 rs6011430 chr20:61497014 C/T cg07645718 chr20:61493192 TCFL5 -0.7 -5.55 -0.32 6.85e-8 Obesity-related traits; CESC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg04025307 chr7:1156635 C7orf50 0.41 6.62 0.38 2.03e-10 Longevity;Endometriosis; CESC cis rs3087591 0.919 rs2018624 chr17:29560777 T/G cg24425628 chr17:29625626 OMG;NF1 -0.43 -5.39 -0.31 1.56e-7 Hip circumference; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08729914 chr12:64845936 TBK1 0.59 7.08 0.4 1.26e-11 Gut microbiome composition (summer); CESC cis rs709400 1.000 rs57218990 chr14:104128007 T/A cg12935359 chr14:103987150 CKB -0.45 -6.09 -0.35 3.94e-9 Body mass index; CESC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg18404041 chr3:52824283 ITIH1 -0.36 -5.68 -0.33 3.45e-8 Bipolar disorder; CESC cis rs17376456 0.877 rs28418572 chr5:93144161 A/C cg21475434 chr5:93447410 FAM172A 0.8 7.24 0.41 4.96e-12 Diabetic retinopathy; CESC cis rs6866344 0.601 rs4419608 chr5:178097049 C/T cg03877680 chr5:178157825 ZNF354A 0.56 5.98 0.34 7.36e-9 Neutrophil percentage of white cells; CESC cis rs2708240 1.000 rs2708238 chr7:147575818 G/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.23e-8 QT interval (drug interaction); CESC cis rs2050392 0.789 rs303438 chr10:30733493 C/T cg18806716 chr10:30721971 MAP3K8 0.46 6.82 0.39 6.1e-11 Inflammatory bowel disease; CESC cis rs41308713 0.606 rs77984335 chr20:37073286 G/A cg09132763 chr20:37064059 LOC388796;SNORA71D 0.79 5.15 0.3 5.07e-7 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs6840258 1.000 rs72667750 chr4:87930425 C/T cg08197287 chr4:87952173 AFF1 -0.41 -5.24 -0.31 3.23e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00306426 chr1:70687415 SFRS11 -0.49 -6.05 -0.35 4.9e-9 Ulcerative colitis; CESC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg14703610 chr5:56206110 C5orf35 -0.41 -5.11 -0.3 6.05e-7 Initial pursuit acceleration; CESC cis rs2996428 0.561 rs12134919 chr1:3744641 G/A cg10555106 chr1:3691387 LOC388588 0.36 5.15 0.3 5.05e-7 Red cell distribution width; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14851770 chr14:50065970 PPIL5 -0.45 -6.08 -0.35 4.15e-9 Fibrinogen levels; CESC cis rs561341 1.000 rs555629 chr17:30294136 T/C cg19193384 chr17:30244184 NA -0.68 -6.43 -0.37 5.9e-10 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24103018 chr19:17420930 DDA1 0.68 8.37 0.46 3.37e-15 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs2815348 chr1:67472165 G/C cg02640540 chr1:67518911 SLC35D1 0.51 5.43 0.32 1.25e-7 Lymphocyte percentage of white cells; CESC cis rs2742234 0.541 rs4648313 chr10:43716739 G/A cg07801480 chr10:43725741 RASGEF1A -0.4 -5.24 -0.31 3.22e-7 Hirschsprung disease; CESC cis rs6831352 0.879 rs34360292 chr4:100051303 T/C cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs7953249 0.656 rs2251468 chr12:121405126 A/C cg02403541 chr12:121454288 C12orf43 0.53 6.93 0.39 3.21e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg03433033 chr1:76189801 ACADM 0.63 6.2 0.36 2.2e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4237845 0.837 rs7971877 chr12:58287630 T/G cg02175503 chr12:58329896 NA 0.56 7.37 0.41 2.17e-12 Intelligence (multi-trait analysis); CESC cis rs9457247 1.000 rs439237 chr6:167391392 A/G cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs3741151 1.000 rs111882289 chr11:73053714 T/C cg17517138 chr11:73019481 ARHGEF17 1.03 7.15 0.4 8.41e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs763014 0.898 rs8060921 chr16:635988 C/A cg09781414 chr16:715207 WDR90 -0.33 -5.04 -0.3 8.57e-7 Height; CESC cis rs7923609 0.846 rs7075901 chr10:65280994 C/A cg01631684 chr10:65280961 REEP3 -0.44 -5.47 -0.32 1.05e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs10791323 0.572 rs1114367 chr11:133737304 G/T cg15485101 chr11:133734466 NA 0.36 6.08 0.35 4.13e-9 Childhood ear infection; CESC cis rs12586317 0.553 rs3809448 chr14:35515096 C/T cg16230307 chr14:35515116 FAM177A1 1.13 11.81 0.59 3.79e-26 Psoriasis; CESC cis rs2367563 0.964 rs7980442 chr12:96056774 T/C cg19013339 chr12:96052514 NTN4 0.37 5.35 0.31 1.92e-7 Allergic dermatitis (nickel); CESC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg13607699 chr17:42295918 UBTF 0.56 7.08 0.4 1.31e-11 Total body bone mineral density; CESC cis rs6942756 0.774 rs6946288 chr7:129004277 A/G cg02491457 chr7:128862824 NA -0.54 -7.47 -0.42 1.15e-12 White matter hyperintensity burden; CESC cis rs3820928 0.874 rs4675132 chr2:227841792 A/C cg11843606 chr2:227700838 RHBDD1 -0.5 -6.48 -0.37 4.5e-10 Pulmonary function; CESC trans rs9322193 0.962 rs2342764 chr6:150156204 G/A cg26879899 chr11:78413596 ODZ4 -0.43 -6.05 -0.35 4.79e-9 Lung cancer; CESC cis rs6484504 0.576 rs208066 chr11:31156206 C/G cg14844989 chr11:31128820 NA -0.42 -5.49 -0.32 9.55e-8 Red blood cell count; CESC cis rs9788333 0.762 rs4441120 chr13:21886863 T/A cg25811766 chr13:21894605 NA 0.78 11.17 0.57 5.26e-24 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs76878669 0.561 rs1784029 chr11:66099987 C/T cg18002602 chr11:66138449 SLC29A2 0.4 6.69 0.38 1.35e-10 Educational attainment (years of education); CESC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg17178900 chr1:205818956 PM20D1 0.54 8.02 0.44 3.47e-14 Menarche (age at onset); CESC cis rs6088590 0.931 rs12625149 chr20:33425812 A/C cg08999081 chr20:33150536 PIGU -0.55 -8.29 -0.45 5.91e-15 Coronary artery disease; CESC cis rs6942756 1.000 rs2141075 chr7:128877305 C/T cg02491457 chr7:128862824 NA 0.7 10.1 0.53 1.63e-20 White matter hyperintensity burden; CESC cis rs7772486 0.875 rs6913797 chr6:146413758 A/G cg23711669 chr6:146136114 FBXO30 0.78 11.68 0.58 1.09e-25 Lobe attachment (rater-scored or self-reported); CESC trans rs11088226 0.692 rs2833863 chr21:33886986 A/G cg09050820 chr6:167586206 TCP10L2 0.52 6.51 0.37 3.78e-10 Gastritis; CESC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg00149659 chr3:10157352 C3orf10 -0.68 -8.53 -0.46 1.15e-15 Alzheimer's disease; CESC cis rs1395 0.710 rs1992291 chr2:27504312 A/G cg22903471 chr2:27725779 GCKR -0.44 -5.51 -0.32 8.64e-8 Blood metabolite levels; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg24158916 chr21:33662961 MRAP 0.41 6.07 0.35 4.49e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10089 0.904 rs3087889 chr5:127524944 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.47 0.5 1.63e-18 Ileal carcinoids; CESC cis rs7584330 0.628 rs73098849 chr2:238389739 G/A cg14458575 chr2:238380390 NA 0.62 5.56 0.32 6.65e-8 Prostate cancer; CESC cis rs977987 0.788 rs7184525 chr16:75437186 A/G cg03315344 chr16:75512273 CHST6 0.41 5.86 0.34 1.35e-8 Dupuytren's disease; CESC cis rs7927771 1.000 rs12421210 chr11:47779586 C/T cg20307385 chr11:47447363 PSMC3 -0.51 -6.24 -0.36 1.74e-9 Subjective well-being; CESC cis rs3741151 0.773 rs17310374 chr11:73274874 T/C cg17517138 chr11:73019481 ARHGEF17 1.03 7.57 0.42 6.07e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg04414720 chr1:150670196 GOLPH3L 0.48 6.55 0.37 2.97e-10 Melanoma; CESC cis rs10791097 0.694 rs2236711 chr11:130739284 G/A cg12179176 chr11:130786555 SNX19 0.65 10.06 0.53 2.26e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg12365402 chr11:9010492 NRIP3 -0.39 -6.55 -0.37 2.93e-10 Hemoglobin concentration; CESC cis rs6912958 0.559 rs369674 chr6:88043402 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.74 -11.62 -0.58 1.69e-25 Monocyte percentage of white cells; CESC cis rs17376456 0.877 rs10059630 chr5:93459807 C/A cg25358565 chr5:93447407 FAM172A 1.15 11.8 0.59 4.11e-26 Diabetic retinopathy; CESC cis rs727505 1.000 rs10228201 chr7:124449895 A/G cg23710748 chr7:124431027 NA -0.44 -6.83 -0.39 5.96e-11 Lewy body disease; CESC cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg23711669 chr6:146136114 FBXO30 0.97 14.47 0.66 2.25e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs11690935 0.549 rs62183819 chr2:172904520 G/T cg13550731 chr2:172543902 DYNC1I2 0.47 6.11 0.35 3.64e-9 Schizophrenia; CESC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg22105103 chr4:187893119 NA 0.5 7.43 0.42 1.48e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg23172400 chr8:95962367 TP53INP1 -0.45 -9.25 -0.49 8.02e-18 Type 2 diabetes; CESC cis rs2180341 1.000 rs6569477 chr6:127589302 T/A cg27446573 chr6:127587934 RNF146 1.07 15.89 0.7 2.11e-40 Breast cancer; CESC cis rs10504229 0.953 rs114806125 chr8:58182416 C/T cg05313129 chr8:58192883 C8orf71 -0.46 -5.71 -0.33 3.1e-8 Developmental language disorder (linguistic errors); CESC trans rs9307551 0.779 rs13124357 chr4:80512302 G/A cg02747103 chr19:603718 HCN2 -0.41 -6.15 -0.35 2.79e-9 Refractive error; CESC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg08859206 chr1:53392774 SCP2 0.71 11.12 0.56 7.71e-24 Monocyte count; CESC cis rs3768617 0.811 rs12144261 chr1:183014148 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 8.79 0.48 1.91e-16 Fuchs's corneal dystrophy; CESC cis rs698833 0.819 rs698772 chr2:44580634 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.87 0.34 1.3e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9457247 0.967 rs2149083 chr6:167370971 G/C cg25258033 chr6:167368657 RNASET2 -0.41 -6.12 -0.35 3.35e-9 Crohn's disease; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg15637191 chr17:38020667 IKZF3 0.46 6.41 0.37 6.61e-10 Attention deficit hyperactivity disorder; CESC trans rs9951602 0.512 rs4799249 chr18:76654370 A/G cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs13191362 0.938 rs13213746 chr6:163167777 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.68 7.21 0.4 5.89e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg06456125 chr7:65229604 NA -0.39 -5.37 -0.31 1.75e-7 Aortic root size; CESC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.51 -7.02 -0.4 1.83e-11 Lymphocyte counts; CESC cis rs12971120 1.000 rs734559 chr18:72179579 G/A cg25817165 chr18:72167213 CNDP2 -0.63 -7.96 -0.44 4.95e-14 Refractive error; CESC cis rs9300255 0.602 rs1790116 chr12:123618544 G/T cg05973401 chr12:123451056 ABCB9 0.51 5.89 0.34 1.15e-8 Neutrophil percentage of white cells; CESC cis rs9399135 0.967 rs13218642 chr6:135309940 A/G cg22676075 chr6:135203613 NA 0.52 7.22 0.41 5.65e-12 Red blood cell count; CESC cis rs1395 0.778 rs6709602 chr2:27405497 C/T cg22903471 chr2:27725779 GCKR -0.42 -5.21 -0.3 3.77e-7 Blood metabolite levels; CESC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg04166393 chr7:2884313 GNA12 0.58 7.31 0.41 3.2e-12 Height; CESC cis rs761746 0.739 rs5753690 chr22:31950005 C/T cg25791279 chr22:32026902 PISD 0.64 7.11 0.4 1.1e-11 Intelligence; CESC cis rs4727963 0.846 rs4316096 chr7:122712475 C/A cg03640110 chr7:122635026 TAS2R16 -0.37 -5.79 -0.34 1.96e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg11644478 chr21:40555479 PSMG1 1.03 16.42 0.71 2.79e-42 Cognitive function; CESC cis rs2262909 0.962 rs390730 chr19:22233509 C/A cg11619707 chr19:22235551 ZNF257 -0.32 -5.13 -0.3 5.65e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs2996428 0.667 rs11578581 chr1:3770642 G/A cg13057898 chr1:3703894 LRRC47 0.44 6.05 0.35 4.92e-9 Red cell distribution width; CESC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg24881330 chr22:46731750 TRMU 0.84 7.55 0.42 7.21e-13 LDL cholesterol;Cholesterol, total; CESC cis rs2243480 0.803 rs35268390 chr7:65416536 C/G cg12463550 chr7:65579703 CRCP 0.69 5.72 0.33 2.85e-8 Diabetic kidney disease; CESC cis rs1595825 0.891 rs7583917 chr2:198576950 A/G cg00982548 chr2:198649783 BOLL -0.48 -5.14 -0.3 5.46e-7 Ulcerative colitis; CESC trans rs4716602 0.596 rs12386682 chr7:156158265 C/T cg07175507 chr18:77160758 NFATC1 -0.45 -6.14 -0.35 3e-9 Anti-saccade response; CESC cis rs2732480 0.577 rs2634684 chr12:48730875 C/T cg24011408 chr12:48396354 COL2A1 -0.39 -5.21 -0.3 3.83e-7 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19752117 chr17:4850710 PFN1 -0.41 -6.07 -0.35 4.31e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16249355 chr17:76310516 NA 0.58 6.93 0.39 3.29e-11 Gut microbiome composition (summer); CESC cis rs11155671 0.530 rs3823021 chr6:150210999 G/C cg09699651 chr6:150184138 LRP11 0.55 7.7 0.43 2.78e-13 Testicular germ cell tumor; CESC cis rs76878669 0.561 rs2236679 chr11:66108894 G/C cg18002602 chr11:66138449 SLC29A2 -0.41 -6.86 -0.39 4.86e-11 Educational attainment (years of education); CESC cis rs7659604 0.605 rs67772833 chr4:122723106 G/A cg06713675 chr4:122721982 EXOSC9 -0.42 -6.08 -0.35 4.24e-9 Type 2 diabetes; CESC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.79 0.33 2.03e-8 Menopause (age at onset); CESC trans rs9388451 0.587 rs1739385 chr6:126099939 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.6 -8.11 -0.45 1.85e-14 Brugada syndrome; CESC cis rs2230307 0.536 rs473759 chr1:100557282 C/G cg24955406 chr1:100503596 HIAT1 0.53 5.41 0.32 1.38e-7 Carotid intima media thickness; CESC cis rs9303280 0.806 rs12709365 chr17:38027400 A/G cg19468946 chr17:37922297 IKZF3 -0.41 -5.45 -0.32 1.16e-7 Self-reported allergy; CESC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg26769984 chr7:1090371 C7orf50 0.62 6.91 0.39 3.64e-11 Bronchopulmonary dysplasia; CESC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg01416388 chr22:39784598 NA -0.58 -7.12 -0.4 9.99e-12 Intelligence (multi-trait analysis); CESC cis rs2832191 0.765 rs2832162 chr21:30461808 G/A cg24692254 chr21:30365293 RNF160 0.83 13.0 0.62 3.29e-30 Dental caries; CESC cis rs2294693 0.947 rs9369254 chr6:40989408 T/C cg14769373 chr6:40998127 UNC5CL -0.48 -6.67 -0.38 1.52e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs11750568 1.000 rs6601013 chr5:178507927 G/A cg10208897 chr5:178548229 ADAMTS2 0.38 5.07 0.3 7.58e-7 Height; CESC cis rs9399401 0.667 rs11155242 chr6:142691549 A/C cg03128060 chr6:142623767 GPR126 0.37 6.51 0.37 3.66e-10 Chronic obstructive pulmonary disease; CESC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg02018176 chr4:1364513 KIAA1530 0.61 7.81 0.43 1.35e-13 Longevity; CESC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg23281280 chr6:28129359 ZNF389 0.48 5.91 0.34 1.02e-8 Depression; CESC cis rs4253772 0.530 rs9615955 chr22:46743931 A/G cg10541313 chr22:46663664 TTC38 0.73 5.12 0.3 6.01e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg27170947 chr2:26402098 FAM59B 0.83 9.39 0.5 2.98e-18 Gut microbiome composition (summer); CESC cis rs6582630 0.519 rs4294627 chr12:38293982 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs3820928 0.874 rs2229813 chr2:227892720 C/T cg11843606 chr2:227700838 RHBDD1 -0.48 -6.46 -0.37 5.02e-10 Pulmonary function; CESC cis rs13102973 1.000 rs11722746 chr4:135850567 A/T cg14419869 chr4:135874104 NA 0.33 5.15 0.3 5.11e-7 Subjective well-being; CESC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg22520471 chr17:61851767 DDX42;CCDC47 -0.89 -13.83 -0.65 4.21e-33 Prudent dietary pattern; CESC cis rs950776 0.518 rs2292117 chr15:78834689 C/T cg06917634 chr15:78832804 PSMA4 0.77 11.63 0.58 1.53e-25 Sudden cardiac arrest; CESC cis rs4642101 0.597 rs9839769 chr3:12821405 C/T cg05775895 chr3:12838266 CAND2 0.41 6.3 0.36 1.2e-9 QRS complex (12-leadsum); CESC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg26516362 chr5:178986906 RUFY1 -0.47 -7.52 -0.42 8.25e-13 Lung cancer; CESC trans rs11039798 0.764 rs7294013 chr11:48762416 G/A cg15704280 chr7:45808275 SEPT13 0.7 6.42 0.37 6.38e-10 Axial length; CESC cis rs4892230 1 rs4892230 chr18:72155572 G/A cg26446133 chr18:72167187 CNDP2 -0.57 -7.77 -0.43 1.77e-13 Mononucleosis; CESC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg11168104 chr5:1857477 NA -0.35 -5.1 -0.3 6.37e-7 Cardiovascular disease risk factors; CESC cis rs17376456 0.825 rs13156202 chr5:93157721 C/T cg25358565 chr5:93447407 FAM172A -1.09 -10.74 -0.55 1.38e-22 Diabetic retinopathy; CESC trans rs3008706 0.920 rs2987043 chr9:16002831 G/T cg09705784 chr17:76565232 DNAH17 0.56 6.01 0.35 6.16e-9 Bilirubin levels; CESC cis rs17253792 0.822 rs8013714 chr14:56172286 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.69 5.94 0.34 8.99e-9 Putamen volume; CESC cis rs4595586 0.811 rs6580849 chr12:39303639 C/A cg26384229 chr12:38710491 ALG10B -0.4 -5.72 -0.33 2.94e-8 Morning vs. evening chronotype; CESC cis rs2204008 0.837 rs11612125 chr12:38213212 C/T cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs10911232 0.507 rs11582514 chr1:182992161 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.23 0.63 5.2e-31 Hypertriglyceridemia; CESC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg11663144 chr21:46675770 NA 0.62 9.8 0.52 1.48e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs6089829 0.962 rs6122350 chr20:61664617 A/G cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs1256061 0.603 rs928554 chr14:64694195 C/T cg21174375 chr14:64681225 SYNE2 0.49 6.51 0.37 3.74e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs713587 0.719 rs58048722 chr2:25187825 C/T cg01884057 chr2:25150051 NA -0.39 -7.31 -0.41 3.2e-12 Body mass index in non-asthmatics; CESC cis rs400736 0.671 rs863171 chr1:7992615 A/G cg25007680 chr1:8021821 PARK7 0.56 8.09 0.44 2.22e-14 Response to antidepressants and depression; CESC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg07701084 chr6:150067640 NUP43 0.48 6.69 0.38 1.35e-10 Lung cancer; CESC cis rs9611565 0.649 rs139553 chr22:42187199 A/G cg06481639 chr22:41940642 POLR3H 0.48 5.56 0.32 6.43e-8 Vitiligo; CESC cis rs7617480 0.648 rs6801211 chr3:48774420 C/G cg06212747 chr3:49208901 KLHDC8B 0.48 5.91 0.34 1.05e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs6582630 0.502 rs11504451 chr12:38425294 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.76 0.33 2.38e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs2242073 0.660 rs11679743 chr2:209004632 C/T cg10392614 chr2:208977121 NA -0.37 -5.04 -0.3 8.76e-7 Attention deficit hyperactivity disorder; CESC cis rs10771431 0.597 rs10843142 chr12:9357502 A/G cg08997352 chr12:9597637 DDX12 -0.73 -9.2 -0.49 1.08e-17 Breast size; CESC cis rs863345 0.604 rs1342950 chr1:158463723 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs8062405 0.755 rs4787455 chr16:28589455 G/A cg07382826 chr16:28625726 SULT1A1 0.4 6.58 0.37 2.54e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22967283 chr7:4815538 KIAA0415 -0.48 -6.5 -0.37 4.01e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.71 -9.96 -0.52 4.58e-20 Platelet count; CESC cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg03467027 chr4:99064603 C4orf37 0.47 5.89 0.34 1.2e-8 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21058987 chr14:50778937 L2HGDH;ATP5S -0.39 -6.04 -0.35 5.12e-9 Gambling; CESC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.16e-7 Aortic root size; CESC cis rs72781680 0.800 rs72780112 chr2:23991182 C/T cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs763014 0.898 rs1045277 chr16:633125 T/C cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02263426 chr18:14378524 NA -0.57 -6.58 -0.37 2.46e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.686 rs4895684 chr6:146114023 A/C cg23711669 chr6:146136114 FBXO30 -0.87 -12.9 -0.62 7.1e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.71 0.62 3.31e-29 Gut microbiome composition (summer); CESC cis rs12142240 0.698 rs67276232 chr1:46825484 T/G cg10495392 chr1:46806563 NSUN4 0.59 6.38 0.36 7.87e-10 Menopause (age at onset); CESC cis rs72781680 0.660 rs72780104 chr2:23983715 A/G cg20701182 chr2:24300061 SF3B14 0.63 5.54 0.32 7.13e-8 Lymphocyte counts; CESC cis rs2295499 0.674 rs34626871 chr4:2637560 C/T cg27239842 chr4:2403781 ZFYVE28 -0.33 -5.39 -0.31 1.56e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg07314337 chr2:153574424 ARL6IP6;PRPF40A -0.47 -6.29 -0.36 1.28e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7116495 0.609 rs12275171 chr11:71835373 C/T cg10381502 chr11:71823885 C11orf51 1.06 6.77 0.38 8.27e-11 Severe influenza A (H1N1) infection; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg04921776 chr17:59564657 NA 0.48 6.76 0.38 8.69e-11 Thyroid stimulating hormone; CESC cis rs881375 0.678 rs10818488 chr9:123705087 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 5.9 0.34 1.11e-8 Rheumatoid arthritis; CESC cis rs6912958 0.712 rs6930600 chr6:88349787 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.24 -0.31 3.32e-7 Monocyte percentage of white cells; CESC cis rs782590 0.902 rs3762513 chr2:55762957 C/T cg18811423 chr2:55921094 PNPT1 0.79 12.54 0.61 1.21e-28 Metabolic syndrome; CESC cis rs35110281 0.837 rs2838336 chr21:45071741 A/G cg01579765 chr21:45077557 HSF2BP 0.57 9.79 0.52 1.58e-19 Mean corpuscular volume; CESC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg17372223 chr3:52568218 NT5DC2 0.42 6.42 0.37 6.33e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12720424 chr1:94713229 NA -0.64 -7.73 -0.43 2.24e-13 Gut microbiome composition (summer); CESC trans rs629535 0.590 rs62513427 chr8:70138891 A/T cg21567404 chr3:27674614 NA -0.83 -9.14 -0.49 1.69e-17 Dupuytren's disease; CESC cis rs3015497 0.653 rs2356455 chr14:51093142 G/A cg09863266 chr14:51125203 SAV1 -0.33 -5.14 -0.3 5.35e-7 Mean platelet volume; CESC cis rs36051895 0.659 rs62543863 chr9:5085417 C/T cg02405213 chr9:5042618 JAK2 -0.53 -6.43 -0.37 6.08e-10 Pediatric autoimmune diseases; CESC cis rs8072100 0.738 rs9915222 chr17:45448615 G/T cg25173405 chr17:45401733 C17orf57 -0.42 -5.27 -0.31 2.8e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs3106136 0.967 rs3106135 chr4:95138308 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.01 -0.4 1.94e-11 Capecitabine sensitivity; CESC trans rs1814175 0.817 rs12287396 chr11:49819798 G/C cg15704280 chr7:45808275 SEPT13 -1.02 -20.13 -0.78 2.46e-55 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18153499 chr19:47142459 NA -0.45 -6.39 -0.37 7.43e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg10691866 chr7:65817282 TPST1 0.31 5.37 0.31 1.75e-7 Aortic root size; CESC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg08859206 chr1:53392774 SCP2 -0.57 -7.34 -0.41 2.62e-12 Monocyte count; CESC cis rs672059 1.000 rs652753 chr1:183156569 A/T ch.1.3577855R chr1:183094577 LAMC1 0.54 6.99 0.39 2.28e-11 Hypertriglyceridemia; CESC cis rs3768617 0.510 rs2027078 chr1:183073478 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.25e-31 Fuchs's corneal dystrophy; CESC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg18876405 chr7:65276391 NA 0.44 5.28 0.31 2.72e-7 Aortic root size; CESC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg10691866 chr7:65817282 TPST1 0.33 5.52 0.32 8.27e-8 Aortic root size; CESC trans rs853679 0.607 rs13197574 chr6:28060239 T/C cg06606381 chr12:133084897 FBRSL1 -1.08 -7.66 -0.43 3.42e-13 Depression; CESC cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg20476274 chr7:133979776 SLC35B4 0.64 9.16 0.49 1.44e-17 Mean platelet volume; CESC cis rs56399783 0.901 rs17300022 chr7:2808517 C/T cg19731401 chr7:2775893 GNA12 -0.64 -5.63 -0.33 4.61e-8 Childhood ear infection; CESC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg21951975 chr1:209979733 IRF6 0.45 7.63 0.42 4.36e-13 Monobrow; CESC cis rs4523957 0.928 rs216209 chr17:2195130 A/G cg16513277 chr17:2031491 SMG6 0.56 7.52 0.42 8.5e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21919602 chr1:242011447 EXO1 0.61 7.15 0.4 8.45e-12 Gut microbiome composition (summer); CESC cis rs1775715 0.737 rs2799018 chr10:32202069 C/T cg18675610 chr10:32216311 ARHGAP12 0.35 5.46 0.32 1.08e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs11792861 0.816 rs11788336 chr9:111688387 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 6.66 0.38 1.56e-10 Menarche (age at onset); CESC cis rs6061231 0.583 rs2427313 chr20:60970675 G/A cg22633769 chr20:60982531 CABLES2 0.65 8.0 0.44 3.78e-14 Colorectal cancer; CESC cis rs314370 1.000 rs314370 chr7:100453208 T/C cg10426581 chr7:100472382 SRRT 0.82 7.99 0.44 4.27e-14 Resting heart rate; CESC cis rs7666738 0.606 rs6852813 chr4:99084671 G/A cg24818145 chr4:99064322 C4orf37 0.39 5.13 0.3 5.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.05 0.3 8.17e-7 Menopause (age at onset); CESC cis rs67478160 0.619 rs11628481 chr14:104241499 C/T cg08213375 chr14:104286397 PPP1R13B 0.55 11.02 0.56 1.72e-23 Schizophrenia; CESC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg08736216 chr1:53307985 ZYG11A -0.36 -6.33 -0.36 1.02e-9 Monocyte count; CESC trans rs2018683 0.803 rs12700920 chr7:28984924 A/G cg19402173 chr7:128379420 CALU -0.59 -7.71 -0.43 2.54e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs611744 0.625 rs11779824 chr8:109278689 G/A cg21045802 chr8:109455806 TTC35 0.49 6.17 0.35 2.48e-9 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02430562 chr19:4831721 TICAM1 0.56 6.27 0.36 1.46e-9 Gut microbiome composition (summer); CESC cis rs9486719 1.000 rs6923212 chr6:97061940 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -8.3 -0.45 5.48e-15 Migraine;Coronary artery disease; CESC cis rs17818399 0.547 rs62134736 chr2:46766446 G/A cg06386533 chr2:46925753 SOCS5 0.49 5.13 0.3 5.63e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01772563 chr7:95064399 PON2 0.67 8.14 0.45 1.57e-14 Gut microbiome composition (summer); CESC cis rs6547741 0.844 rs55826602 chr2:27863452 A/G cg27432699 chr2:27873401 GPN1 -0.59 -8.65 -0.47 4.89e-16 Oral cavity cancer; CESC cis rs10504073 0.647 rs4873312 chr8:49991145 A/G cg00325661 chr8:49890786 NA 0.55 8.05 0.44 2.78e-14 Blood metabolite ratios; CESC trans rs1814175 0.615 rs11040654 chr11:49939485 T/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.65 0.47 4.88e-16 Menopause (age at onset); CESC cis rs77697190 1.000 rs78284524 chr14:103844854 G/A cg09975044 chr14:104007538 NA -0.86 -5.42 -0.32 1.32e-7 Mean corpuscular hemoglobin; CESC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.8 0.59 4.3e-26 Alzheimer's disease; CESC cis rs11122272 0.735 rs2808602 chr1:231537303 A/G cg06096015 chr1:231504339 EGLN1 0.42 6.07 0.35 4.33e-9 Hemoglobin concentration; CESC cis rs8016982 0.651 rs1885601 chr14:81641210 C/T cg01989461 chr14:81687754 GTF2A1 0.74 11.25 0.57 3e-24 Schizophrenia; CESC cis rs7809799 1.000 rs117557270 chr7:98780753 C/T cg05967295 chr7:98741636 SMURF1 0.89 5.57 0.32 6.3e-8 Ulcerative colitis; CESC cis rs6598163 0.517 rs11246827 chr12:132296423 G/A cg07389463 chr12:132296394 NA 0.43 6.18 0.35 2.46e-9 Migraine; CESC cis rs78648104 0.541 rs56987137 chr6:50879555 C/T cg11790335 chr6:50679857 TFAP2D 0.55 5.37 0.31 1.72e-7 Systolic blood pressure; CESC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.39e-30 Prudent dietary pattern; CESC trans rs877282 1.000 rs10904552 chr10:774326 A/G cg22713356 chr15:30763199 NA 1.13 11.36 0.57 1.23e-24 Uric acid levels; CESC cis rs1551570 0.755 rs2290687 chr19:10229521 C/T cg00593900 chr19:10206746 ANGPTL6 0.37 6.1 0.35 3.68e-9 Narcolepsy; CESC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg11301795 chr4:187892539 NA -0.71 -11.21 -0.57 3.97e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs1499614 1.000 rs2707828 chr7:66171377 G/A cg12463550 chr7:65579703 CRCP 0.73 5.73 0.33 2.78e-8 Gout; CESC cis rs9611565 0.525 rs9611548 chr22:41704143 G/T cg17376030 chr22:41985996 PMM1 0.54 5.84 0.34 1.53e-8 Vitiligo; CESC cis rs2735413 0.881 rs4888732 chr16:78080505 A/G cg04733911 chr16:78082701 NA -0.51 -8.38 -0.46 3.17e-15 Systolic blood pressure (alcohol consumption interaction); CESC cis rs60154123 0.554 rs1338290 chr1:210465467 G/A cg25204440 chr1:209979598 IRF6 0.48 5.21 0.3 3.75e-7 Coronary artery disease; CESC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs12313068 0.709 rs10849698 chr12:110504798 C/G cg12870014 chr12:110450643 ANKRD13A 0.83 9.51 0.5 1.22e-18 Intelligence (multi-trait analysis); CESC cis rs728616 0.614 rs17678737 chr10:82133985 A/G cg05935833 chr10:81318306 SFTPA2 -0.46 -5.7 -0.33 3.26e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg04315214 chr1:2043799 PRKCZ 0.64 11.01 0.56 1.81e-23 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02213487 chr11:118928076 HYOU1 -0.51 -6.32 -0.36 1.11e-9 Ulcerative colitis; CESC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Tonsillectomy; CESC cis rs10870270 1.000 rs3935905 chr10:133758262 A/C cg17892150 chr10:133769511 PPP2R2D -0.85 -12.56 -0.61 1.02e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs911555 0.755 rs12432803 chr14:103930032 C/T cg24130564 chr14:104152367 KLC1 0.49 6.32 0.36 1.11e-9 Intelligence (multi-trait analysis); CESC cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.03e-7 Colorectal cancer; CESC cis rs1395 0.778 rs12465084 chr2:27414203 G/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 5.85 0.34 1.44e-8 Blood metabolite levels; CESC cis rs11098499 0.818 rs10008791 chr4:120431469 A/C cg09307838 chr4:120376055 NA 0.93 12.81 0.62 1.5e-29 Corneal astigmatism; CESC cis rs8005677 1.000 rs4982706 chr14:23381697 C/T cg01529538 chr14:23388837 RBM23 0.51 6.87 0.39 4.64e-11 Cognitive ability (multi-trait analysis); CESC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 9.46 0.5 1.8e-18 Platelet count; CESC cis rs212524 0.544 rs7551107 chr1:21559702 C/A cg05370193 chr1:21551575 ECE1 0.4 6.34 0.36 9.62e-10 Height; CESC cis rs60154123 0.772 rs664072 chr1:210422160 G/A cg22029157 chr1:209979665 IRF6 0.49 5.59 0.32 5.6e-8 Coronary artery disease; CESC cis rs763014 0.966 rs15564 chr16:677854 G/T cg09263875 chr16:632152 PIGQ 0.66 11.46 0.58 5.98e-25 Height; CESC cis rs8017423 0.967 rs55962513 chr14:90729460 C/G cg14092571 chr14:90743983 NA -0.56 -8.38 -0.46 3.07e-15 Mortality in heart failure; CESC cis rs4919044 0.756 rs2486686 chr10:94778511 G/T cg26979504 chr10:94451518 HHEX -0.47 -5.15 -0.3 5.16e-7 Coronary artery disease; CESC cis rs9287719 0.934 rs10201077 chr2:10752426 A/C cg00105475 chr2:10696890 NA 0.38 5.41 0.32 1.43e-7 Prostate cancer; CESC cis rs36051895 0.659 rs59225790 chr9:5042757 G/A cg02405213 chr9:5042618 JAK2 -0.49 -5.86 -0.34 1.38e-8 Pediatric autoimmune diseases; CESC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Depression; CESC cis rs501120 1.000 rs620828 chr10:44760958 A/G cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.1e-11 Coronary artery disease;Coronary heart disease; CESC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg10691866 chr7:65817282 TPST1 -0.35 -5.76 -0.33 2.36e-8 Aortic root size; CESC cis rs965469 0.779 rs2236119 chr20:3303576 G/T cg25506879 chr20:3388711 C20orf194 -0.49 -5.36 -0.31 1.79e-7 IFN-related cytopenia; CESC cis rs7914558 1.000 rs7094843 chr10:104806654 A/C cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.49e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1514687 0.534 rs60151917 chr2:1473286 A/T cg13703866 chr2:1479523 TPO -0.77 -5.24 -0.31 3.35e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs684232 0.688 rs2657633 chr17:600502 C/T cg15660573 chr17:549704 VPS53 -0.67 -9.4 -0.5 2.73e-18 Prostate cancer; CESC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg06456125 chr7:65229604 NA -0.39 -5.1 -0.3 6.54e-7 Aortic root size; CESC cis rs2832191 0.791 rs2832181 chr21:30481371 G/T cg08807101 chr21:30365312 RNF160 -0.77 -11.04 -0.56 1.46e-23 Dental caries; CESC cis rs6540556 0.723 rs12034758 chr1:209920545 G/A cg05527609 chr1:210001259 C1orf107 -0.65 -7.5 -0.42 9.5e-13 Red blood cell count; CESC cis rs3741151 0.773 rs6592526 chr11:73208911 C/T cg17517138 chr11:73019481 ARHGEF17 0.98 7.17 0.4 7.42e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg27170947 chr2:26402098 FAM59B 0.87 9.85 0.52 1.01e-19 Gut microbiome composition (summer); CESC cis rs7829975 0.714 rs11777085 chr8:8672429 G/C cg06636001 chr8:8085503 FLJ10661 0.43 5.53 0.32 7.54e-8 Mood instability; CESC trans rs561341 0.882 rs16967101 chr17:30377162 A/G cg20587970 chr11:113659929 NA -1.06 -12.78 -0.62 1.88e-29 Hip circumference adjusted for BMI; CESC cis rs3845702 0.736 rs72960701 chr2:180851202 A/T cg01881094 chr2:180872142 CWC22 1.03 8.81 0.48 1.65e-16 Schizophrenia; CESC cis rs7592578 0.766 rs62182885 chr2:191437024 A/G cg10560079 chr2:191398806 TMEM194B -0.61 -5.19 -0.3 4.22e-7 Diastolic blood pressure; CESC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.3 -0.5 5.54e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2777491 1.000 rs11631770 chr15:41737059 T/C cg02330683 chr15:41787940 ITPKA 0.45 6.56 0.37 2.89e-10 Ulcerative colitis; CESC cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -5.04 -0.3 8.68e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7264396 0.563 rs2425117 chr20:34323776 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -10.47 -0.54 1.06e-21 Total cholesterol levels; CESC cis rs2455799 0.502 rs2470532 chr3:15696909 A/C cg16303742 chr3:15540471 COLQ 0.4 6.32 0.36 1.11e-9 Mean platelet volume; CESC cis rs4664308 0.935 rs17216980 chr2:160960932 G/A cg03641300 chr2:160917029 PLA2R1 -0.62 -8.98 -0.48 5.24e-17 Idiopathic membranous nephropathy; CESC cis rs4566357 1.000 rs7567789 chr2:227922104 T/C cg11843606 chr2:227700838 RHBDD1 -0.41 -5.27 -0.31 2.78e-7 Coronary artery disease; CESC cis rs7412746 0.611 rs4970985 chr1:150887442 C/T cg04414720 chr1:150670196 GOLPH3L -0.45 -5.99 -0.35 6.85e-9 Melanoma; CESC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.59 -0.38 2.36e-10 Depression; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03531512 chr22:26908677 TFIP11 0.41 6.01 0.35 6.26e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12497850 1.000 rs6788650 chr3:48749543 T/C cg06212747 chr3:49208901 KLHDC8B 0.61 8.15 0.45 1.46e-14 Parkinson's disease; CESC cis rs7255374 0.566 rs7255904 chr19:41529020 C/T cg27089200 chr19:41531976 NA 0.44 7.3 0.41 3.27e-12 DDT metabolite (p,p'-DDE levels); CESC cis rs8114671 0.869 rs66535333 chr20:33656666 G/A cg06115741 chr20:33292138 TP53INP2 -0.44 -5.31 -0.31 2.27e-7 Height; CESC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg23978390 chr7:1156363 C7orf50 0.43 5.71 0.33 3.06e-8 Longevity;Endometriosis; CESC cis rs7560272 0.501 rs2421676 chr2:73966087 G/A cg20560298 chr2:73613845 ALMS1 0.4 5.5 0.32 8.75e-8 Schizophrenia; CESC cis rs72829446 0.530 rs2228132 chr17:7411770 C/T cg02795151 chr17:7402630 POLR2A 0.62 6.48 0.37 4.49e-10 Androgen levels; CESC cis rs4906332 1.000 rs3783397 chr14:103947289 A/G cg09975044 chr14:104007538 NA 0.44 6.19 0.36 2.31e-9 Coronary artery disease; CESC cis rs6502050 0.835 rs3935816 chr17:80137173 C/T cg23985595 chr17:80112537 CCDC57 -0.39 -6.27 -0.36 1.44e-9 Life satisfaction; CESC cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.62 7.29 0.41 3.65e-12 Age-related macular degeneration (geographic atrophy); CESC cis rs7123876 0.587 rs11602616 chr11:72364077 T/C cg03713592 chr11:72463424 ARAP1 0.62 5.08 0.3 7.13e-7 Body mass index; CESC cis rs7188697 0.922 rs1549607 chr16:58583975 A/G cg21335942 chr16:58549945 SETD6 -0.46 -5.35 -0.31 1.9e-7 QT interval; CESC cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.03e-7 Colorectal cancer; CESC cis rs1003719 0.788 rs61701101 chr21:38450317 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.64 0.47 5.56e-16 Eye color traits; CESC cis rs7481584 0.624 rs516443 chr11:3047294 A/G cg25174290 chr11:3078921 CARS -0.45 -6.3 -0.36 1.21e-9 Calcium levels; CESC cis rs7917772 0.503 rs11191326 chr10:104302959 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.76 -0.33 2.3e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24869748 chr6:86303744 SNX14 -0.47 -6.47 -0.37 4.72e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4595586 0.545 rs7486598 chr12:39371159 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.51 0.42 8.86e-13 Morning vs. evening chronotype; CESC cis rs9640161 0.830 rs7800196 chr7:150061534 C/G cg10018233 chr7:150070692 REPIN1 0.39 6.47 0.37 4.6e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs7301826 0.651 rs2037789 chr12:131288292 C/T cg11011512 chr12:131303247 STX2 -0.47 -5.79 -0.34 2e-8 Plasma plasminogen activator levels; CESC cis rs2235642 0.787 rs2235646 chr16:1601287 A/G cg09080909 chr16:1797204 MAPK8IP3 -0.37 -5.06 -0.3 7.96e-7 Coronary artery disease; CESC cis rs10088262 0.629 rs12549683 chr8:124798276 G/C cg15047889 chr8:124780837 FAM91A1 -0.52 -6.58 -0.37 2.57e-10 Pancreatic cancer; CESC cis rs636291 0.517 rs12565133 chr1:10544988 A/C cg20482658 chr1:10539492 PEX14 0.26 5.36 0.31 1.84e-7 Prostate cancer; CESC cis rs9911578 0.933 rs2632508 chr17:56533235 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.4 5.3 0.31 2.49e-7 Intelligence (multi-trait analysis); CESC cis rs10754283 0.967 rs7528433 chr1:90114071 T/C cg21401794 chr1:90099060 LRRC8C 0.68 9.03 0.49 3.6e-17 Amyotrophic lateral sclerosis (sporadic); CESC cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg19193384 chr17:30244184 NA -0.71 -6.6 -0.38 2.17e-10 Hip circumference adjusted for BMI; CESC cis rs796364 0.616 rs6718118 chr2:200691852 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.56 -5.4 -0.31 1.46e-7 Schizophrenia; CESC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg17971929 chr21:40555470 PSMG1 -0.8 -11.0 -0.56 2.03e-23 Cognitive function; CESC cis rs1348850 0.793 rs13027299 chr2:178455501 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.9 0.44 7.42e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7542091 0.637 rs9429826 chr1:210052146 G/A cg21951975 chr1:209979733 IRF6 0.46 7.95 0.44 5.33e-14 Monobrow; CESC cis rs17401966 0.838 rs4846207 chr1:10313811 T/C cg15208524 chr1:10270712 KIF1B 0.39 5.13 0.3 5.5e-7 Hepatocellular carcinoma; CESC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg11663144 chr21:46675770 NA -0.63 -10.04 -0.53 2.57e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7397814 0.558 rs4764447 chr12:9579109 C/T cg27502298 chr12:9555721 NA 0.79 10.72 0.55 1.65e-22 IgG glycosylation; CESC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg24675658 chr1:53192096 ZYG11B 0.63 8.83 0.48 1.44e-16 Monocyte count; CESC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09829838 chr6:42952307 PPP2R5D 0.52 6.04 0.35 5.32e-9 Gut microbiome composition (summer); CESC cis rs453301 0.653 rs11784393 chr8:8903134 C/T cg15556689 chr8:8085844 FLJ10661 0.51 6.5 0.37 3.86e-10 Joint mobility (Beighton score); CESC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18320648 chr2:152266336 RIF1 -0.5 -6.83 -0.39 5.94e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg04511125 chr2:88470314 THNSL2 -0.67 -6.37 -0.36 8.22e-10 Plasma clusterin levels; CESC cis rs1499972 0.618 rs62264778 chr3:117653627 G/T cg07612923 chr3:117604196 NA 0.68 6.16 0.35 2.74e-9 Schizophrenia; CESC cis rs796364 0.901 rs4673762 chr2:201065171 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.62 5.79 0.33 2.03e-8 Schizophrenia; CESC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.11 -0.3 6.15e-7 Breast cancer; CESC cis rs12042107 0.740 rs10801826 chr1:91206578 C/T cg13456504 chr1:91191583 NA -0.34 -5.79 -0.34 1.99e-8 Educational attainment; CESC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg01324507 chr7:1177794 C7orf50 0.54 5.35 0.31 1.88e-7 Bronchopulmonary dysplasia; CESC cis rs10504229 0.500 rs9772760 chr8:57986999 G/C cg22535103 chr8:58192502 C8orf71 -0.47 -5.88 -0.34 1.24e-8 Developmental language disorder (linguistic errors); CESC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.95 11.67 0.58 1.1e-25 Platelet count; CESC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg02569458 chr12:86230093 RASSF9 0.48 7.32 0.41 2.89e-12 Major depressive disorder; CESC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg08027265 chr7:2291960 NA -0.37 -5.53 -0.32 7.61e-8 Bipolar disorder and schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06160880 chr1:235324713 RBM34 -0.52 -6.05 -0.35 4.93e-9 Ulcerative colitis; CESC cis rs4629710 0.592 rs10484763 chr6:131549060 T/C cg12606694 chr6:131520996 AKAP7 0.43 5.43 0.32 1.26e-7 Multiple myeloma (IgH translocation); CESC cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6500602 0.647 rs4786519 chr16:4584406 C/T cg08645402 chr16:4508243 NA 0.5 8.21 0.45 9.85e-15 Schizophrenia; CESC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg27211696 chr2:191398769 TMEM194B 0.49 7.29 0.41 3.51e-12 Pulse pressure; CESC cis rs3809863 0.602 rs7225700 chr17:45391804 T/C cg08085267 chr17:45401833 C17orf57 -0.68 -9.09 -0.49 2.38e-17 Glaucoma (primary open-angle); CESC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.06 -12.27 -0.6 1.02e-27 Gut microbiome composition (summer); CESC cis rs8031584 1.000 rs35811129 chr15:31241346 G/A cg14298792 chr15:30685198 CHRFAM7A -0.48 -5.41 -0.32 1.39e-7 Huntington's disease progression; CESC cis rs17601876 0.843 rs28490942 chr15:51559845 G/C cg19946085 chr15:51559439 CYP19A1 -0.32 -5.15 -0.3 5.01e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs8114671 0.836 rs6060165 chr20:33619480 A/C cg24642439 chr20:33292090 TP53INP2 -0.44 -5.29 -0.31 2.57e-7 Height; CESC cis rs6963495 0.606 rs6969426 chr7:105147150 G/A cg13798780 chr7:105162888 PUS7 0.75 7.64 0.43 3.87e-13 Bipolar disorder (body mass index interaction); CESC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg11764359 chr7:65958608 NA -0.92 -14.87 -0.67 9.11e-37 Aortic root size; CESC cis rs8070624 0.543 rs4299203 chr17:17878159 T/G cg16928487 chr17:17741425 SREBF1 -0.62 -10.37 -0.54 2.2e-21 Total body bone mineral density; CESC trans rs7937682 0.883 rs631490 chr11:111452040 G/C cg18187862 chr3:45730750 SACM1L 0.48 6.13 0.35 3.15e-9 Primary sclerosing cholangitis; CESC cis rs6831352 0.819 rs896992 chr4:100002372 C/T cg21548116 chr4:100009993 ADH5 0.46 5.12 0.3 5.86e-7 Alcohol dependence; CESC cis rs3820928 0.874 rs116652884 chr2:227902285 C/T cg11843606 chr2:227700838 RHBDD1 -0.5 -6.54 -0.37 3.22e-10 Pulmonary function; CESC cis rs7937682 0.889 rs564086 chr11:111501079 C/G cg22437258 chr11:111473054 SIK2 0.68 9.04 0.49 3.37e-17 Primary sclerosing cholangitis; CESC trans rs17685 0.753 rs2108274 chr7:75781636 C/A cg19862616 chr7:65841803 NCRNA00174 0.87 12.64 0.61 5.4e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs7100689 0.577 rs1417219 chr10:82041409 C/T cg09936400 chr10:82049201 MAT1A 0.41 6.24 0.36 1.7e-9 Post bronchodilator FEV1; CESC cis rs17039065 0.920 rs12507588 chr4:109448257 G/A cg16022748 chr4:109541635 LOC285456;RPL34 0.63 5.67 0.33 3.65e-8 Gut microbiome composition (summer); CESC cis rs12325245 0.536 rs17821549 chr16:58554780 C/T cg02549819 chr16:58548995 SETD6 0.93 6.23 0.36 1.85e-9 Schizophrenia; CESC cis rs10463316 0.894 rs869198 chr5:150745893 G/T cg03212797 chr5:150827313 SLC36A1 0.55 7.31 0.41 3.13e-12 Metabolite levels (Pyroglutamine); CESC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg17971929 chr21:40555470 PSMG1 -0.6 -7.94 -0.44 5.64e-14 Menarche (age at onset); CESC cis rs3796352 1.000 rs71301814 chr3:53117663 G/A cg15956490 chr3:53032818 SFMBT1 0.63 5.22 0.31 3.63e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs863345 0.604 rs11264976 chr1:158446927 G/A cg12129480 chr1:158549410 OR10X1 -0.36 -7.18 -0.4 7.1e-12 Pneumococcal bacteremia; CESC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg11890956 chr21:40555474 PSMG1 -0.96 -15.83 -0.7 3.49e-40 Cognitive function; CESC cis rs12142240 0.698 rs45449893 chr1:46859024 A/G cg10495392 chr1:46806563 NSUN4 0.56 6.17 0.35 2.61e-9 Menopause (age at onset); CESC cis rs1348850 0.914 rs12104588 chr2:178253675 G/A cg23306229 chr2:178417860 TTC30B 0.64 8.07 0.44 2.52e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10504229 0.679 rs72649120 chr8:58040308 C/T cg24829409 chr8:58192753 C8orf71 -0.5 -6.25 -0.36 1.61e-9 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10205151 chr7:931109 C7orf20 -0.65 -7.31 -0.41 3.18e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25989624 chr9:132199563 NA -0.62 -6.57 -0.37 2.63e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12058646 chr3:45017840 ZDHHC3;EXOSC7 -0.61 -7.13 -0.4 9.32e-12 Gut microbiome composition (summer); CESC cis rs9902453 0.817 rs62068620 chr17:28167674 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.38 0.46 3.08e-15 Coffee consumption (cups per day); CESC cis rs1552244 0.554 rs34883592 chr3:10046165 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -7.26 -0.41 4.31e-12 Alzheimer's disease; CESC cis rs854765 0.583 rs11656840 chr17:17837354 C/T cg16928487 chr17:17741425 SREBF1 -0.56 -9.73 -0.51 2.53e-19 Total body bone mineral density; CESC cis rs826838 0.933 rs1906263 chr12:38653362 T/C cg26384229 chr12:38710491 ALG10B 0.82 14.26 0.66 1.22e-34 Heart rate; CESC cis rs7615952 0.673 rs115942855 chr3:125601960 G/A cg05084668 chr3:125655381 ALG1L -0.82 -7.68 -0.43 3.04e-13 Blood pressure (smoking interaction); CESC cis rs8133932 0.608 rs403192 chr21:47360641 C/T cg14185626 chr21:47401492 COL6A1 -0.46 -5.14 -0.3 5.24e-7 Schizophrenia; CESC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg03351412 chr1:154909251 PMVK 0.69 9.39 0.5 2.91e-18 Prostate cancer; CESC cis rs7818345 0.967 rs10107416 chr8:19286253 A/G cg11303988 chr8:19266685 CSGALNACT1 -0.3 -5.52 -0.32 8.16e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs12545109 0.842 rs10958482 chr8:57389331 G/T cg09654669 chr8:57350985 NA -0.57 -7.13 -0.4 9.65e-12 Obesity-related traits; CESC cis rs34779708 0.931 rs34304999 chr10:35365705 C/T cg04310649 chr10:35416472 CREM -0.49 -5.92 -0.34 9.74e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs4595586 0.545 rs1607041 chr12:39368206 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.51 0.32 8.37e-8 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg26338869 chr17:61819248 STRADA 0.67 8.9 0.48 9.05e-17 Prudent dietary pattern; CESC cis rs1018836 0.818 rs2285232 chr8:91546162 C/G cg16814680 chr8:91681699 NA -0.63 -9.06 -0.49 2.89e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7605827 0.930 rs4668910 chr2:15608013 C/A cg19274914 chr2:15703543 NA 0.38 6.75 0.38 9.33e-11 Educational attainment (years of education); CESC cis rs3087591 1.000 rs9902893 chr17:29625638 G/A cg24425628 chr17:29625626 OMG;NF1 -0.41 -5.04 -0.3 8.71e-7 Hip circumference; CESC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg03605463 chr16:89740564 NA 0.66 7.83 0.43 1.14e-13 Vitiligo; CESC cis rs4566357 0.539 rs10933164 chr2:227860671 A/G cg05526886 chr2:227700861 RHBDD1 -0.62 -7.23 -0.41 5.21e-12 Coronary artery disease; CESC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg24549020 chr5:56110836 MAP3K1 -0.6 -7.14 -0.4 8.97e-12 Initial pursuit acceleration; CESC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg21770322 chr7:97807741 LMTK2 0.55 8.18 0.45 1.17e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs7927771 1.000 rs10838757 chr11:47763016 T/C cg18512352 chr11:47633146 NA -0.61 -9.62 -0.51 5.51e-19 Subjective well-being; CESC cis rs2797160 1.000 rs1739378 chr6:126012262 C/A cg05901451 chr6:126070800 HEY2 0.46 6.68 0.38 1.4e-10 Endometrial cancer; CESC cis rs7659604 0.540 rs11734075 chr4:122695685 C/T cg19748678 chr4:122722346 EXOSC9 -0.45 -5.73 -0.33 2.73e-8 Type 2 diabetes; CESC cis rs3087591 1.000 rs2051507 chr17:29700101 A/G cg24425628 chr17:29625626 OMG;NF1 -0.46 -5.84 -0.34 1.51e-8 Hip circumference; CESC cis rs12541635 0.677 rs6469032 chr8:107057509 A/T cg10147462 chr8:107024639 NA 0.47 6.96 0.39 2.64e-11 Age of smoking initiation; CESC cis rs7258465 1.000 rs34746918 chr19:18539744 C/T cg25828334 chr19:18545568 ISYNA1 -0.32 -5.15 -0.3 5e-7 Breast cancer; CESC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg23281280 chr6:28129359 ZNF389 0.39 5.92 0.34 9.72e-9 Cardiac Troponin-T levels; CESC cis rs4253772 0.938 rs9626814 chr22:46637254 C/T cg24881330 chr22:46731750 TRMU 0.53 5.3 0.31 2.41e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg13880726 chr7:1868755 MAD1L1 0.51 6.98 0.39 2.4e-11 Bipolar disorder and schizophrenia; CESC cis rs13102973 0.965 rs55967588 chr4:135860189 G/A cg14419869 chr4:135874104 NA 0.34 5.24 0.31 3.3e-7 Subjective well-being; CESC cis rs3733585 0.605 rs4697926 chr4:10124567 G/T cg11266682 chr4:10021025 SLC2A9 0.56 10.27 0.53 4.87e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.42 6.86 0.39 4.72e-11 Personality dimensions; CESC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg23758822 chr17:41437982 NA 1.04 15.67 0.69 1.25e-39 Menopause (age at onset); CESC cis rs941873 0.868 rs10740497 chr10:81126380 T/C cg11057378 chr10:81107060 PPIF 0.36 5.84 0.34 1.55e-8 Height; CESC cis rs7927592 0.956 rs60212556 chr11:68305494 C/T cg20283391 chr11:68216788 NA -0.5 -5.91 -0.34 1.02e-8 Total body bone mineral density; CESC trans rs861318 0.838 rs855866 chr1:159052720 A/G cg08477332 chr1:153590243 S100A14 0.64 6.03 0.35 5.59e-9 Obesity-related traits; CESC cis rs1562975 0.609 rs12505944 chr4:109411822 G/A cg16022748 chr4:109541635 LOC285456;RPL34 0.42 5.4 0.31 1.48e-7 Height; CESC cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg14780466 chr2:20870812 GDF7 0.41 7.25 0.41 4.48e-12 Abdominal aortic aneurysm; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09410845 chr2:203241870 BMPR2 -0.61 -6.57 -0.37 2.66e-10 Gut microbiome composition (summer); CESC trans rs17508449 0.819 rs2146018 chr1:114195330 C/A cg23028848 chr11:57092561 TNKS1BP1 -0.75 -6.05 -0.35 4.88e-9 Leprosy; CESC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.35 0.36 9.24e-10 Prudent dietary pattern; CESC cis rs11690935 0.843 rs9784070 chr2:172785007 C/T cg13550731 chr2:172543902 DYNC1I2 -0.84 -12.21 -0.6 1.67e-27 Schizophrenia; CESC cis rs250677 0.687 rs36048 chr5:148441713 G/C cg18129178 chr5:148520854 ABLIM3 -0.52 -5.94 -0.34 8.86e-9 Breast cancer; CESC cis rs34375054 0.526 rs883315 chr12:125676889 T/C cg05341575 chr12:125625032 AACS -0.36 -5.23 -0.31 3.51e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs2108622 0.727 rs12611308 chr19:15978586 C/T cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs7818688 1.000 rs73276437 chr8:96035511 A/G cg16049864 chr8:95962084 TP53INP1 0.6 5.79 0.34 2e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -6.17 -0.35 2.56e-9 Mood instability; CESC cis rs2380220 0.872 rs4546494 chr6:95990626 A/C cg15832292 chr6:96025679 MANEA 0.64 6.19 0.36 2.22e-9 Behavioural disinhibition (generation interaction); CESC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC cis rs55871839 0.708 rs13268621 chr8:59811724 T/G cg07426533 chr8:59803705 TOX -0.47 -7.01 -0.4 1.95e-11 Pneumonia; CESC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg12288994 chr5:1860383 NA 0.4 6.66 0.38 1.53e-10 Cardiovascular disease risk factors; CESC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg24829409 chr8:58192753 C8orf71 -0.69 -7.74 -0.43 2.07e-13 Developmental language disorder (linguistic errors); CESC cis rs367943 0.712 rs6896650 chr5:112681048 T/C cg12552261 chr5:112820674 MCC 0.4 5.25 0.31 3.09e-7 Type 2 diabetes; CESC cis rs6831352 1.000 rs1126673 chr4:100045616 C/T cg13256891 chr4:100009986 ADH5 0.72 8.31 0.45 5.11e-15 Alcohol dependence; CESC cis rs6570726 0.935 rs453609 chr6:145812332 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.36 0.36 8.67e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4835473 0.897 rs6831477 chr4:144630640 G/A cg25736465 chr4:144833511 NA 0.4 6.09 0.35 3.86e-9 Immature fraction of reticulocytes; CESC cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg14416269 chr4:6271139 WFS1 0.44 7.22 0.41 5.49e-12 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9435341 1.000 rs1762484 chr1:107613923 A/C cg09367891 chr1:107599246 PRMT6 -0.69 -8.25 -0.45 7.61e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.75 0.33 2.4e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2191566 1.000 rs367499 chr19:44504981 G/A cg20607764 chr19:44506953 ZNF230 0.6 7.68 0.43 2.99e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.87 13.69 0.64 1.22e-32 Hip circumference adjusted for BMI; CESC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg09455208 chr3:40491958 NA 0.51 8.55 0.47 9.79e-16 Renal cell carcinoma; CESC cis rs9868809 0.772 rs9811318 chr3:48702606 A/G cg07636037 chr3:49044803 WDR6 -0.69 -6.17 -0.35 2.56e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg12826209 chr6:26865740 GUSBL1 0.76 8.46 0.46 1.79e-15 Intelligence (multi-trait analysis); CESC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 5.67 0.33 3.7e-8 Bipolar disorder; CESC cis rs72781680 0.706 rs72794290 chr2:23896106 A/T cg08917208 chr2:24149416 ATAD2B 1.17 10.84 0.55 6.84e-23 Lymphocyte counts; CESC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.97 0.59 1.11e-26 Alzheimer's disease; CESC cis rs7089973 0.604 rs8181444 chr10:116588981 C/T cg03647239 chr10:116582469 FAM160B1 0.43 5.29 0.31 2.6e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs62432291 0.764 rs433256 chr6:159660105 C/T cg14500486 chr6:159655392 FNDC1 -0.62 -6.34 -0.36 9.83e-10 Joint mobility (Beighton score); CESC cis rs7223966 1.000 rs9903903 chr17:61762044 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.42 0.41 1.55e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2797160 0.904 rs1739370 chr6:126011231 C/T cg05901451 chr6:126070800 HEY2 0.48 7.04 0.4 1.63e-11 Endometrial cancer; CESC cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg07636037 chr3:49044803 WDR6 1.02 18.99 0.76 2.3e-51 Parkinson's disease; CESC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg12311346 chr5:56204834 C5orf35 -0.55 -6.81 -0.39 6.5e-11 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21767207 chr19:36236454 PSENEN;U2AF1L4 0.67 8.03 0.44 3.11e-14 Gut microbiome composition (summer); CESC cis rs1729951 0.575 rs2163896 chr3:136691177 G/A cg03617693 chr3:136751559 NA 0.39 5.38 0.31 1.68e-7 Neuroticism; CESC cis rs1451375 0.617 rs10276473 chr7:50612997 A/C cg14593290 chr7:50529359 DDC -0.49 -6.05 -0.35 4.91e-9 Malaria; CESC cis rs4889855 0.516 rs4890041 chr17:78521114 A/T cg16591659 chr17:78472290 NA 0.35 5.81 0.34 1.81e-8 Fractional excretion of uric acid; CESC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg17971929 chr21:40555470 PSMG1 -1.06 -15.79 -0.7 4.77e-40 Cognitive function; CESC cis rs4460629 0.742 rs7548955 chr1:155082298 T/C cg01019262 chr1:155095195 NA -0.3 -5.09 -0.3 6.75e-7 Serum magnesium levels; CESC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg22467129 chr15:76604101 ETFA -0.41 -6.23 -0.36 1.83e-9 Blood metabolite levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23325985 chr12:49350513 ARF3 0.44 6.23 0.36 1.86e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2573652 0.755 rs1469830 chr15:100517403 G/T cg09918751 chr15:100517450 ADAMTS17 0.45 8.82 0.48 1.56e-16 Height; CESC cis rs9291683 0.618 rs13137343 chr4:10043028 C/A cg02734326 chr4:10020555 SLC2A9 0.47 6.53 0.37 3.29e-10 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18220030 chr1:110090737 GNAI3 -0.54 -6.45 -0.37 5.34e-10 Gut microbiome composition (summer); CESC cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg18876405 chr7:65276391 NA 0.5 5.5 0.32 8.91e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12333112 chr17:38278849 MSL1 0.55 6.02 0.35 5.8e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg06634786 chr22:41940651 POLR3H -0.6 -6.45 -0.37 5.32e-10 Vitiligo; CESC cis rs2120019 0.638 rs12050628 chr15:75333494 G/A cg09165964 chr15:75287851 SCAMP5 0.94 15.9 0.7 1.93e-40 Blood trace element (Zn levels); CESC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg17724175 chr1:150552817 MCL1 0.33 5.15 0.3 5.17e-7 Melanoma; CESC cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg24879335 chr3:133465180 TF 0.32 5.06 0.3 7.71e-7 Iron status biomarkers; CESC cis rs7772486 0.743 rs9390344 chr6:146012755 C/G cg23711669 chr6:146136114 FBXO30 -0.83 -11.77 -0.59 5.44e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs3008870 0.755 rs2755251 chr1:67496425 G/T cg02640540 chr1:67518911 SLC35D1 0.44 5.4 0.31 1.48e-7 Lymphocyte percentage of white cells; CESC cis rs4699052 0.626 rs10017383 chr4:104249957 G/A cg16532752 chr4:104119610 CENPE -0.41 -5.85 -0.34 1.44e-8 Testicular germ cell tumor; CESC cis rs6893300 0.961 rs62406223 chr5:179218361 C/T cg14593053 chr5:179126677 CANX -0.51 -5.62 -0.33 4.9e-8 Resting heart rate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02853107 chr4:41984968 DCAF4L1 0.43 6.22 0.36 1.93e-9 Fibrinogen levels; CESC cis rs12534701 1.000 rs13232266 chr7:154681363 A/T cg24255201 chr7:154684926 DPP6 0.5 6.91 0.39 3.61e-11 Colorectal cancer (diet interaction); CESC cis rs454510 0.816 rs347904 chr1:120177620 C/T cg11530693 chr1:120165357 ZNF697 0.45 5.73 0.33 2.66e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06438337 chr1:202858236 RABIF 0.55 6.1 0.35 3.78e-9 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.01 0.4 2e-11 Bipolar disorder; CESC cis rs909002 0.772 rs10914452 chr1:32074575 G/A cg13919466 chr1:32135498 COL16A1 -0.47 -8.52 -0.46 1.24e-15 Intelligence (multi-trait analysis); CESC cis rs992157 0.585 rs62182795 chr2:219100202 C/T cg00012203 chr2:219082015 ARPC2 -0.74 -9.9 -0.52 7.06e-20 Colorectal cancer; CESC cis rs3924048 0.559 rs6541038 chr1:12626210 G/T cg00291366 chr1:12616550 NA 0.37 6.5 0.37 3.87e-10 Optic cup area; CESC cis rs1691799 0.777 rs11176145 chr12:66719795 A/G cg16791601 chr12:66731901 HELB 0.59 8.69 0.47 3.93e-16 White blood cell count (basophil); CESC cis rs7124681 0.585 rs10838773 chr11:47834346 G/A cg20307385 chr11:47447363 PSMC3 0.6 8.27 0.45 6.34e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs919433 0.963 rs10199410 chr2:198155776 A/T cg03934865 chr2:198174659 NA -0.46 -6.97 -0.39 2.51e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs9467711 0.606 rs12174623 chr6:26373086 C/T cg06606381 chr12:133084897 FBRSL1 -0.76 -7.04 -0.4 1.64e-11 Autism spectrum disorder or schizophrenia; CESC cis rs1559088 0.948 rs7257858 chr19:33591231 T/C cg27124370 chr19:33622961 WDR88 0.45 6.0 0.35 6.49e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs34779708 0.733 rs4007271 chr10:35546611 C/T cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -6.35 -0.36 9.11e-10 Schizophrenia; CESC cis rs9303280 0.806 rs12941333 chr17:38040534 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.42 -0.32 1.31e-7 Self-reported allergy; CESC cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.2 0.3 3.91e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4862307 0.688 rs6552741 chr4:184990335 A/G cg06737308 chr4:185021514 ENPP6 -0.46 -6.34 -0.36 9.93e-10 Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs1348850 0.958 rs1405713 chr2:178461560 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.62 0.47 6.11e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10089 1.000 rs10478798 chr5:127442394 C/T cg19767477 chr5:127420684 SLC12A2 -0.42 -5.66 -0.33 3.84e-8 Ileal carcinoids; CESC cis rs652260 0.819 rs55656533 chr19:7902976 G/C cg26014689 chr19:7917955 EVI5L -0.44 -5.92 -0.34 9.75e-9 Menarche (age at onset); CESC cis rs854765 0.583 rs8073001 chr17:17831716 A/C cg09796270 chr17:17721594 SREBF1 -0.45 -6.44 -0.37 5.45e-10 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12149777 chr4:139937459 CCRN4L 0.66 7.91 0.44 6.78e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13786666 chr9:86536028 KIF27 0.54 6.53 0.37 3.34e-10 Gut microbiome composition (summer); CESC cis rs11190604 1.000 rs10883497 chr10:102228519 A/G cg07080220 chr10:102295463 HIF1AN 0.57 5.82 0.34 1.7e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs11039798 0.610 rs11530356 chr11:48836290 C/A cg15704280 chr7:45808275 SEPT13 0.71 6.44 0.37 5.59e-10 Axial length; CESC cis rs1707322 1.000 rs7526369 chr1:46390560 G/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12200560 0.505 rs211163 chr6:97067654 A/G cg06623918 chr6:96969491 KIAA0776 0.46 5.8 0.34 1.92e-8 Coronary heart disease; CESC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg11987759 chr7:65425863 GUSB 0.47 6.37 0.36 8.53e-10 Aortic root size; CESC cis rs7703051 0.901 rs6896136 chr5:74787310 T/C cg03227963 chr5:74354835 NA 0.3 5.38 0.31 1.67e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg22638593 chr5:131593259 PDLIM4 0.43 5.67 0.33 3.68e-8 Breast cancer; CESC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.45 0.37 5.14e-10 Intelligence (multi-trait analysis); CESC cis rs2304069 0.545 rs7445660 chr5:149413610 A/C cg12661370 chr5:149340060 SLC26A2 0.48 6.49 0.37 4.12e-10 HIV-1 control; CESC cis rs10510653 0.522 rs58075697 chr3:32023275 G/C cg05935571 chr3:32023257 ZNF860;OSBPL10 0.96 8.71 0.47 3.43e-16 Schizophrenia; CESC cis rs3820068 0.705 rs4646110 chr1:15817318 A/T cg17385448 chr1:15911702 AGMAT 0.39 6.13 0.35 3.14e-9 Systolic blood pressure; CESC cis rs7267979 0.873 rs6083853 chr20:25404541 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -15.69 -0.69 1.07e-39 Liver enzyme levels (alkaline phosphatase); CESC cis rs752010 0.756 rs943374 chr1:42056194 A/G cg06885757 chr1:42089581 HIVEP3 0.48 7.8 0.43 1.47e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.64 0.38 1.75e-10 Prudent dietary pattern; CESC cis rs9916302 0.752 rs9901219 chr17:37558369 T/G cg07936489 chr17:37558343 FBXL20 0.98 13.6 0.64 2.6e-32 Glomerular filtration rate (creatinine); CESC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg11890956 chr21:40555474 PSMG1 1.13 19.25 0.76 2.85e-52 Cognitive function; CESC cis rs2425143 1.000 rs6058311 chr20:34321895 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.3 0.31 2.46e-7 Blood protein levels; CESC trans rs1003719 0.715 rs762139 chr21:38568475 A/T cg12989020 chr6:157098657 ARID1B -0.43 -6.06 -0.35 4.69e-9 Eye color traits; CESC cis rs1707322 0.963 rs10789484 chr1:46406978 G/C cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8114671 0.967 rs1415774 chr20:33765616 C/T cg24642439 chr20:33292090 TP53INP2 -0.43 -5.23 -0.31 3.49e-7 Height; CESC trans rs561341 1.000 rs757009 chr17:30243937 A/G cg20587970 chr11:113659929 NA -0.83 -10.48 -0.54 9.94e-22 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01627046 chr12:125473657 DHX37 0.7 7.65 0.43 3.84e-13 Gut microbiome composition (summer); CESC cis rs911555 0.755 rs975892 chr14:103883349 A/T cg24130564 chr14:104152367 KLC1 -0.5 -6.75 -0.38 9.28e-11 Intelligence (multi-trait analysis); CESC cis rs67311347 0.549 rs60249586 chr3:40246659 G/A cg09455208 chr3:40491958 NA 0.33 5.24 0.31 3.34e-7 Renal cell carcinoma; CESC trans rs9951602 0.512 rs73494176 chr18:76644895 T/C cg02800362 chr5:177631904 HNRNPAB 0.62 8.16 0.45 1.36e-14 Obesity-related traits; CESC cis rs6831352 0.918 rs17218239 chr4:100057020 G/A cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs718433 0.584 rs7158042 chr14:22221077 A/G cg02257791 chr14:22217085 NA 0.33 5.24 0.31 3.32e-7 Intraocular pressure; CESC cis rs1190552 0.846 rs11623570 chr14:102959277 G/T cg18135206 chr14:102964638 TECPR2 0.41 5.13 0.3 5.7e-7 Blood protein levels; CESC cis rs763121 0.853 rs138706 chr22:39137834 C/G cg06022373 chr22:39101656 GTPBP1 0.92 17.08 0.72 1.33e-44 Menopause (age at onset); CESC trans rs61931739 0.500 rs28692887 chr12:34457075 G/A cg26384229 chr12:38710491 ALG10B 0.69 10.44 0.54 1.34e-21 Morning vs. evening chronotype; CESC cis rs2712184 1.000 rs2712184 chr2:217682779 G/T cg05032264 chr2:217675019 NA -0.37 -5.6 -0.33 5.43e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC trans rs10435719 0.867 rs34583868 chr8:11791383 G/T cg15556689 chr8:8085844 FLJ10661 0.52 6.35 0.36 9.52e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs7312933 1.000 rs12372623 chr12:42531666 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.44 5.86 0.34 1.38e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7927592 0.956 rs12365160 chr11:68250419 A/G cg20283391 chr11:68216788 NA -0.51 -6.17 -0.35 2.55e-9 Total body bone mineral density; CESC cis rs1790761 0.587 rs7934075 chr11:67295949 T/C cg08355456 chr11:67383691 NA -0.32 -5.15 -0.3 5.13e-7 Mean corpuscular volume; CESC cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg00684032 chr4:1343700 KIAA1530 0.44 6.79 0.38 7.31e-11 Longevity; CESC cis rs4073405 0.584 rs2902433 chr11:45301131 G/C cg27235148 chr11:45376932 NA -0.29 -5.11 -0.3 6.11e-7 Schizophrenia; CESC trans rs13179617 0.928 rs11952146 chr5:60818863 A/G cg05478497 chr12:4274287 NA -0.35 -6.02 -0.35 5.91e-9 Intelligence (multi-trait analysis); CESC cis rs208520 0.690 rs2797693 chr6:66868985 T/C cg07460842 chr6:66804631 NA -0.99 -13.52 -0.64 4.76e-32 Exhaled nitric oxide output; CESC trans rs9325144 0.647 rs11168104 chr12:38857616 G/T cg23762105 chr12:34175262 ALG10 0.46 6.04 0.35 5.3e-9 Morning vs. evening chronotype; CESC cis rs12618769 0.597 rs17031146 chr2:99036683 A/G cg10123293 chr2:99228465 UNC50 0.4 5.48 0.32 9.88e-8 Bipolar disorder; CESC cis rs3781913 1.000 rs3781913 chr11:72373496 A/C cg04827223 chr11:72435913 ARAP1 0.33 5.1 0.3 6.56e-7 Rheumatoid arthritis; CESC cis rs7927771 0.524 rs12785949 chr11:47729770 C/T cg18512352 chr11:47633146 NA 0.34 5.26 0.31 3e-7 Subjective well-being; CESC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs798766 1.000 rs798762 chr4:1731150 T/C cg07041428 chr4:1763019 NA -0.41 -5.78 -0.33 2.1e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs6800768 0.633 rs62255803 chr3:24149030 T/C cg10674438 chr3:24145617 LOC152024 -0.47 -6.46 -0.37 5.08e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4268898 0.552 rs4665663 chr2:24372139 G/C cg06627628 chr2:24431161 ITSN2 0.6 8.31 0.45 5.17e-15 Asthma; CESC cis rs9660992 0.548 rs1172152 chr1:205220718 T/A cg00857998 chr1:205179979 DSTYK 0.56 6.84 0.39 5.58e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs6460942 0.915 rs62447639 chr7:12486803 T/C cg06484146 chr7:12443880 VWDE -0.77 -8.63 -0.47 5.59e-16 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13453304 chr18:77493499 CTDP1 0.51 6.54 0.37 3.15e-10 Fibrinogen levels; CESC cis rs56046484 0.871 rs35000527 chr15:85553781 A/G cg08123816 chr15:85640762 PDE8A -0.5 -5.94 -0.34 9.11e-9 Testicular germ cell tumor; CESC cis rs344364 0.511 rs1742463 chr16:1946110 A/G cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs9872999 1 rs9872999 chr3:133457514 C/T cg18769074 chr3:133464867 TF 0.3 5.87 0.34 1.33e-8 Iron status biomarkers; CESC cis rs8027181 1.000 rs4776613 chr15:73080731 C/T cg25632853 chr15:73088954 NA 0.37 6.38 0.37 7.72e-10 Triglyceride levels; CESC cis rs7772486 0.817 rs2748491 chr6:146327759 T/C cg23711669 chr6:146136114 FBXO30 0.82 11.62 0.58 1.68e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs11577318 0.812 rs3795683 chr1:26632831 C/A cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.52 -0.37 3.53e-10 Granulocyte percentage of myeloid white cells; CESC cis rs6088580 0.634 rs9789792 chr20:32957709 G/A cg06115741 chr20:33292138 TP53INP2 -0.46 -5.89 -0.34 1.14e-8 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10137979 chr8:110346498 ENY2;NUDCD1 -0.42 -6.01 -0.35 5.95e-9 Fibrinogen levels; CESC cis rs460214 0.528 rs6517474 chr21:40023133 G/A cg05519781 chr21:40033154 ERG -0.46 -5.5 -0.32 8.79e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs992157 0.560 rs12992937 chr2:219087072 A/T cg00012203 chr2:219082015 ARPC2 -0.74 -9.9 -0.52 7.06e-20 Colorectal cancer; CESC cis rs4635969 0.718 rs27071 chr5:1346081 T/C cg06550200 chr5:1325588 CLPTM1L -0.69 -7.86 -0.43 9.7e-14 Testicular germ cell tumor;Testicular germ cell cancer; CESC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg17372223 chr3:52568218 NT5DC2 0.51 7.91 0.44 6.97e-14 Electroencephalogram traits; CESC trans rs10506458 0.688 rs60936040 chr12:63416461 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.05 -13.59 -0.64 2.8099999999999997e-32 Hemostatic factors and hematological phenotypes; CESC cis rs651907 0.557 rs12629658 chr3:101356535 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 5.86 0.34 1.35e-8 Colorectal cancer; CESC cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7833986 0.501 rs72653986 chr8:57035048 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.57 7.28 0.41 3.83e-12 Height; CESC cis rs3820068 0.603 rs35509554 chr1:15993514 C/T cg18133145 chr1:16060689 PLEKHM2 -0.42 -5.37 -0.31 1.76e-7 Systolic blood pressure; CESC cis rs13253111 0.646 rs36046709 chr8:28078214 A/T cg26534493 chr8:28060551 NA 0.53 8.16 0.45 1.37e-14 Childhood body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10481400 chr16:67596437 CTCF 0.56 6.16 0.35 2.63e-9 Gut microbiome composition (summer); CESC cis rs854765 0.547 rs7224047 chr17:17932931 G/A cg04398451 chr17:18023971 MYO15A -0.71 -10.37 -0.54 2.34e-21 Total body bone mineral density; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg11654179 chr12:57998762 DTX3 -0.46 -6.02 -0.35 5.64e-9 Recombination measurement; CESC cis rs72781680 1.000 rs72796351 chr2:24158425 T/C cg08917208 chr2:24149416 ATAD2B 0.94 8.66 0.47 4.66e-16 Lymphocyte counts; CESC cis rs34734847 1.000 rs34734847 chr12:121154221 T/C cg21892295 chr12:121157589 UNC119B -0.42 -6.65 -0.38 1.66e-10 Mean corpuscular volume; CESC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.46 -0.32 1.08e-7 Aortic root size; CESC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg13880726 chr7:1868755 MAD1L1 0.51 6.78 0.38 8e-11 Bipolar disorder and schizophrenia; CESC cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.45 0.46 2e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3820928 0.967 rs4675114 chr2:227768362 C/T cg05526886 chr2:227700861 RHBDD1 -0.43 -5.54 -0.32 7.16e-8 Pulmonary function; CESC cis rs2228479 0.557 rs34420680 chr16:89809171 C/T cg06558623 chr16:89946397 TCF25 1.16 9.1 0.49 2.17e-17 Skin colour saturation; CESC cis rs7818345 0.845 rs4256608 chr8:19267560 A/G cg11303988 chr8:19266685 CSGALNACT1 0.35 6.13 0.35 3.21e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs10927875 0.596 rs1806990 chr1:16129377 G/A cg05821634 chr1:16164109 FLJ37453 0.35 5.08 0.3 6.97e-7 Dilated cardiomyopathy; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04787407 chr4:99916511 METAP1 -0.46 -6.5 -0.37 3.9e-10 Height; CESC cis rs1008375 1.000 rs28501187 chr4:17643620 G/A cg16339924 chr4:17578868 LAP3 0.58 7.25 0.41 4.56e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg22907277 chr7:1156413 C7orf50 0.42 5.07 0.3 7.35e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11864453 1.000 rs7201491 chr16:72034312 G/A cg16558253 chr16:72132732 DHX38 -0.46 -6.77 -0.38 8.41e-11 Fibrinogen levels; CESC cis rs933688 1.000 rs10073657 chr5:90689749 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.97 12.98 0.62 3.7e-30 Smoking behavior; CESC cis rs7617480 0.648 rs6801211 chr3:48774420 C/G cg07636037 chr3:49044803 WDR6 0.82 12.17 0.6 2.33e-27 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs3733585 0.699 rs6449157 chr4:9960442 G/A cg11266682 chr4:10021025 SLC2A9 -0.6 -11.22 -0.57 3.77e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs116095464 0.558 rs7708515 chr5:234989 C/G cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.3 0.31 2.49e-7 Breast cancer; CESC cis rs77861329 1.000 rs352148 chr3:52208898 A/G cg08692210 chr3:52188851 WDR51A 0.77 6.3 0.36 1.21e-9 Macrophage inflammatory protein 1b levels; CESC cis rs611744 0.870 rs596703 chr8:109160146 A/G cg21045802 chr8:109455806 TTC35 -0.44 -5.45 -0.32 1.13e-7 Dupuytren's disease; CESC cis rs138171347 1 rs138171347 chr17:5183203 AAAAT/A cg24500398 chr17:5266808 RABEP1 -0.47 -6.74 -0.38 9.85e-11 White blood cell count; CESC cis rs28374715 0.635 rs8023530 chr15:41647775 T/C cg20272979 chr15:41787780 ITPKA 0.38 5.17 0.3 4.7e-7 Ulcerative colitis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15437133 chr10:77160907 ZNF503;C10orf41 -0.48 -6.75 -0.38 9.49e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17376456 1.000 rs59472588 chr5:93511981 A/G cg21475434 chr5:93447410 FAM172A 0.85 7.73 0.43 2.19e-13 Diabetic retinopathy; CESC cis rs2228479 0.850 rs62056091 chr16:89930414 G/A cg00800038 chr16:89945340 TCF25 -0.93 -7.46 -0.42 1.28e-12 Skin colour saturation; CESC cis rs910316 0.789 rs12894419 chr14:75471802 C/T cg16144293 chr14:75469539 EIF2B2 -0.4 -5.27 -0.31 2.82e-7 Height; CESC cis rs1801251 1.000 rs2675974 chr2:233727071 A/G cg25237894 chr2:233734115 C2orf82 0.47 8.51 0.46 1.31e-15 Coronary artery disease; CESC cis rs739401 0.967 rs451041 chr11:3060725 C/T cg08508325 chr11:3079039 CARS -0.4 -7.47 -0.42 1.14e-12 Longevity; CESC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg08027265 chr7:2291960 NA -0.37 -5.63 -0.33 4.58e-8 Schizophrenia; CESC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg06484146 chr7:12443880 VWDE -0.73 -8.75 -0.47 2.6e-16 Coronary artery disease; CESC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg25427524 chr10:38739819 LOC399744 -0.7 -10.24 -0.53 6.01e-21 Extrinsic epigenetic age acceleration; CESC cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg18904891 chr8:8559673 CLDN23 0.71 8.07 0.44 2.44e-14 Obesity-related traits; CESC cis rs8017423 0.845 rs8005870 chr14:90723172 A/C cg14092571 chr14:90743983 NA -0.56 -8.36 -0.46 3.6e-15 Mortality in heart failure; CESC cis rs27434 0.660 rs26493 chr5:96155318 C/T cg16492584 chr5:96139282 ERAP1 -0.46 -5.52 -0.32 7.92e-8 Ankylosing spondylitis; CESC cis rs3105593 1.000 rs3131573 chr15:50869601 G/A cg08437265 chr15:50716283 USP8 0.41 5.29 0.31 2.62e-7 QT interval; CESC cis rs72781680 0.821 rs11894756 chr2:24170214 A/G cg08917208 chr2:24149416 ATAD2B -0.6 -5.96 -0.34 8.12e-9 Lymphocyte counts; CESC cis rs9399135 0.967 rs9376082 chr6:135346389 T/A cg24558204 chr6:135376177 HBS1L 0.51 7.19 0.4 6.72e-12 Red blood cell count; CESC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.51 7.22 0.41 5.61e-12 Menopause (age at onset); CESC cis rs9486719 1.000 rs12207570 chr6:96987884 A/C cg18709589 chr6:96969512 KIAA0776 -0.5 -5.5 -0.32 9.03e-8 Migraine;Coronary artery disease; CESC cis rs3820928 0.904 rs1835159 chr2:227764057 A/G cg05526886 chr2:227700861 RHBDD1 -0.42 -5.45 -0.32 1.15e-7 Pulmonary function; CESC cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg23711669 chr6:146136114 FBXO30 0.99 15.04 0.68 2.25e-37 Lobe attachment (rater-scored or self-reported); CESC trans rs9785234 0.540 rs10819950 chr9:98935333 C/T cg09119967 chr20:9494838 C20orf103 -0.38 -6.07 -0.35 4.37e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.71 7.16 0.4 8.16e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs892961 1.000 rs892961 chr17:75400100 A/T cg05865280 chr17:75406074 SEPT9 0.59 6.11 0.35 3.49e-9 Airflow obstruction; CESC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg11764359 chr7:65958608 NA -0.71 -9.5 -0.5 1.32e-18 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05688084 chr1:19578805 MRTO4;KIAA0090 0.42 6.41 0.37 6.8e-10 Gambling; CESC cis rs7107174 0.892 rs10793310 chr11:78099014 T/G cg02023728 chr11:77925099 USP35 0.47 6.17 0.35 2.54e-9 Testicular germ cell tumor; CESC cis rs11958404 0.615 rs7703242 chr5:157447920 T/C cg05962755 chr5:157440814 NA 0.38 5.65 0.33 4.21e-8 IgG glycosylation; CESC trans rs1814175 0.645 rs847632 chr11:49926097 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -6.25 -0.36 1.68e-9 Height; CESC cis rs1707322 0.752 rs11488313 chr1:46224780 G/C cg05343316 chr1:45956843 TESK2 0.5 6.29 0.36 1.32e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs73058052 1.000 rs3760707 chr19:50084454 T/C cg09250473 chr19:50168907 IRF3;BCL2L12 0.56 5.26 0.31 2.94e-7 Fibrinogen levels; CESC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg00166722 chr3:10149974 C3orf24 0.46 5.89 0.34 1.18e-8 Alzheimer's disease; CESC cis rs7264396 0.563 rs6060569 chr20:34290731 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.78 -0.55 1.03e-22 Total cholesterol levels; CESC cis rs4253772 0.744 rs1134224 chr22:46633371 A/T cg09491104 chr22:46646882 C22orf40 -0.57 -8.87 -0.48 1.14e-16 LDL cholesterol;Cholesterol, total; CESC cis rs2230307 0.536 rs57637634 chr1:100447467 G/A cg24955406 chr1:100503596 HIAT1 0.51 5.16 0.3 4.74e-7 Carotid intima media thickness; CESC trans rs74054849 0.850 rs6692555 chr1:16012657 C/T cg06826283 chr7:600452 PRKAR1B -0.7 -6.22 -0.36 1.96e-9 Alcoholic chronic pancreatitis; CESC cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs3780486 0.713 rs3780489 chr9:33129844 G/T cg13443165 chr9:33130375 B4GALT1 0.45 6.46 0.37 5.07e-10 IgG glycosylation; CESC cis rs10751667 1.000 rs10794349 chr11:945678 T/C cg01483505 chr11:975446 AP2A2 0.4 5.27 0.31 2.9e-7 Alzheimer's disease (late onset); CESC cis rs11098499 0.820 rs6829903 chr4:120506884 C/T cg09307838 chr4:120376055 NA 0.93 12.6 0.61 7.82e-29 Corneal astigmatism; CESC cis rs2191566 0.506 rs396116 chr19:44494583 A/G cg20607764 chr19:44506953 ZNF230 0.45 5.69 0.33 3.34e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs854765 0.547 rs7223696 chr17:17915791 G/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.38 0.41 2.08e-12 Total body bone mineral density; CESC cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg14558114 chr2:88469736 THNSL2 -0.49 -6.96 -0.39 2.6e-11 Response to metformin (IC50); CESC cis rs34779708 0.966 rs6481941 chr10:35440141 G/A cg03585969 chr10:35415529 CREM 0.76 9.96 0.52 4.69e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg03060546 chr3:49711283 APEH 0.51 6.31 0.36 1.14e-9 Parkinson's disease; CESC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg18446336 chr7:2847575 GNA12 -0.36 -5.64 -0.33 4.32e-8 Height; CESC cis rs72781680 0.898 rs17462670 chr2:24026579 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC trans rs9650657 0.537 rs7016385 chr8:10779472 A/G cg15556689 chr8:8085844 FLJ10661 0.5 6.11 0.35 3.6e-9 Neuroticism; CESC cis rs7692995 1.000 rs7696532 chr4:18029299 C/T cg08925142 chr4:18023851 LCORL -0.44 -5.08 -0.3 7.07e-7 Height; CESC cis rs921968 0.643 rs832801 chr2:219488698 G/A cg02176678 chr2:219576539 TTLL4 0.37 6.33 0.36 1.07e-9 Mean corpuscular hemoglobin concentration; CESC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg17372223 chr3:52568218 NT5DC2 0.43 6.36 0.36 9.03e-10 Bipolar disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07552157 chr3:142720316 SR140 -0.46 -6.1 -0.35 3.65e-9 Ulcerative colitis; CESC cis rs7829975 0.774 rs11775523 chr8:8679176 A/G cg06636001 chr8:8085503 FLJ10661 0.45 5.82 0.34 1.69e-8 Mood instability; CESC cis rs4906332 1.000 rs12896612 chr14:103877868 A/G cg09975044 chr14:104007538 NA 0.45 6.17 0.35 2.56e-9 Coronary artery disease; CESC cis rs412000 0.554 rs2680700 chr17:56440542 G/T cg12560992 chr17:57184187 TRIM37 0.63 7.72 0.43 2.38e-13 Primary tooth development (time to first tooth eruption); CESC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg04267008 chr7:1944627 MAD1L1 -0.57 -6.89 -0.39 4.08e-11 Bipolar disorder and schizophrenia; CESC trans rs4596713 0.538 rs7030146 chr9:71756390 T/G cg16512924 chr15:28394682 HERC2 0.51 6.62 0.38 1.93e-10 Headache; CESC cis rs4654899 0.802 rs76122612 chr1:21243059 C/T cg05370193 chr1:21551575 ECE1 0.38 5.51 0.32 8.66e-8 Superior frontal gyrus grey matter volume; CESC cis rs12477438 0.520 rs11123761 chr2:99705903 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.92 15.78 0.7 5.4e-40 Chronic sinus infection; CESC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -6.79 -0.38 7.35e-11 Bipolar disorder; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg01431559 chr13:73305955 C13orf34 0.38 6.03 0.35 5.38e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3820068 0.603 rs72645900 chr1:15931980 A/T cg16988262 chr1:15930761 NA 0.33 5.35 0.31 1.89e-7 Systolic blood pressure; CESC cis rs5758659 0.652 rs133340 chr22:42417687 A/T cg15557168 chr22:42548783 NA 0.44 6.6 0.38 2.28e-10 Cognitive function; CESC cis rs34779708 0.966 rs12784482 chr10:35446865 A/G cg03585969 chr10:35415529 CREM 0.77 10.24 0.53 6.08e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs11722228 1.000 rs11722228 chr4:9915741 C/T cg00071950 chr4:10020882 SLC2A9 0.57 8.47 0.46 1.73e-15 Gout;Urate levels;Serum uric acid levels; CESC cis rs1152591 0.562 rs1272715 chr14:64651989 A/T cg21174375 chr14:64681225 SYNE2 0.55 7.73 0.43 2.17e-13 Atrial fibrillation; CESC cis rs28830936 1.000 rs4924575 chr15:42096926 C/T cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.41 -5.59 -0.32 5.56e-8 Diastolic blood pressure; CESC cis rs4689388 0.890 rs6446481 chr4:6295583 C/A cg00701064 chr4:6280414 WFS1 0.66 11.15 0.57 6.2e-24 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs3020736 0.500 rs8138678 chr22:42516229 A/G cg04733989 chr22:42467013 NAGA -0.78 -11.72 -0.58 7.82e-26 Autism spectrum disorder or schizophrenia; CESC cis rs8028182 0.549 rs11072542 chr15:75634599 G/A cg20655648 chr15:75932815 IMP3 -0.43 -5.36 -0.31 1.78e-7 Sudden cardiac arrest; CESC cis rs9948 1.000 rs62152793 chr2:97484948 C/T cg01990225 chr2:97406019 LMAN2L -0.78 -5.5 -0.32 9.06e-8 Erectile dysfunction and prostate cancer treatment; CESC cis rs10504229 0.516 rs58244172 chr8:57987805 G/A cg24829409 chr8:58192753 C8orf71 -0.36 -5.08 -0.3 7.21e-7 Developmental language disorder (linguistic errors); CESC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg26314531 chr2:26401878 FAM59B -0.59 -6.74 -0.38 9.88e-11 Gut microbiome composition (summer); CESC cis rs8070624 0.574 rs11078408 chr17:17876011 A/G cg04398451 chr17:18023971 MYO15A -0.75 -10.67 -0.55 2.48e-22 Total body bone mineral density; CESC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC cis rs7532866 0.885 rs7552065 chr1:26731951 G/T cg17456097 chr1:26900765 RPS6KA1 -0.47 -6.04 -0.35 5.31e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01222216 chr16:2648276 PDPK1 -0.57 -6.63 -0.38 1.89e-10 Gut microbiome composition (summer); CESC cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg15782153 chr7:917662 C7orf20 -0.47 -5.12 -0.3 5.77e-7 Cerebrospinal P-tau181p levels; CESC cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg08564027 chr20:61660810 NA 0.9 15.44 0.69 8.75e-39 Prostate cancer (SNP x SNP interaction); CESC trans rs7618501 1.000 rs4855867 chr3:49745822 C/T cg21659725 chr3:3221576 CRBN -0.82 -13.57 -0.64 3.35e-32 Intelligence (multi-trait analysis); CESC cis rs11048434 0.736 rs12821842 chr12:9108984 G/A cg23795048 chr12:9217529 LOC144571 0.35 5.4 0.31 1.52e-7 Sjögren's syndrome; CESC cis rs28830936 0.932 rs1105881 chr15:42072530 C/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.46 -6.35 -0.36 9.24e-10 Diastolic blood pressure; CESC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg19717773 chr7:2847554 GNA12 -0.57 -8.18 -0.45 1.18e-14 Height; CESC cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg16339924 chr4:17578868 LAP3 0.74 9.65 0.51 4.51e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4727027 0.901 rs6944781 chr7:148829566 A/G cg23583168 chr7:148888333 NA -0.74 -10.89 -0.56 4.6e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7923609 1.000 rs4595427 chr10:65012944 A/C cg01631684 chr10:65280961 REEP3 -0.44 -5.48 -0.32 9.99e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs9914578 1.000 rs9914578 chr17:2005136 C/G cg16513277 chr17:2031491 SMG6 -0.58 -6.67 -0.38 1.51e-10 Body mass index; CESC cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg09060608 chr5:178986726 RUFY1 0.42 5.76 0.33 2.31e-8 Lung cancer; CESC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.7 -7.87 -0.44 8.94e-14 Gut microbiome composition (summer); CESC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg04108127 chr1:222885781 AIDA;C1orf58 -0.4 -6.08 -0.35 4.13e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CESC cis rs6568686 0.627 rs174377 chr6:111908646 C/A cg22127309 chr6:111907043 TRAF3IP2 0.53 5.2 0.3 3.91e-7 Depressive and manic episodes in bipolar disorder;Depressive episodes in bipolar disorder; CESC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -12.98 -0.62 3.88e-30 Developmental language disorder (linguistic errors); CESC cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg20503657 chr10:835505 NA 1.07 9.91 0.52 6.79e-20 Eosinophil percentage of granulocytes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18126572 chr7:43909213 MRPS24 -0.5 -6.35 -0.36 9.05e-10 Ulcerative colitis; CESC trans rs208520 0.690 rs10455595 chr6:66738034 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.26 0.6 1.09e-27 Exhaled nitric oxide output; CESC cis rs863345 0.604 rs10908658 chr1:158465256 A/G cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg20243544 chr17:37824526 PNMT 0.48 5.93 0.34 9.26e-9 Glomerular filtration rate (creatinine); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14014699 chr9:139685500 TMEM141 -0.42 -6.35 -0.36 9.45e-10 Gambling; CESC cis rs8072100 0.782 rs62074054 chr17:45771816 T/C cg08085267 chr17:45401833 C17orf57 -0.43 -5.43 -0.32 1.27e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2404602 0.692 rs34272342 chr15:77012276 A/C cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs4642101 0.737 rs4447735 chr3:12825513 C/T cg05775895 chr3:12838266 CAND2 0.39 5.99 0.35 6.8e-9 QRS complex (12-leadsum); CESC cis rs2280018 0.526 rs2966128 chr16:15153389 G/T cg07549590 chr16:15018862 NA -0.6 -9.63 -0.51 5.22e-19 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04228274 chr13:21751145 MRP63;SKA3 0.53 6.06 0.35 4.54e-9 Gut microbiome composition (summer); CESC cis rs3126085 0.877 rs4457589 chr1:152247860 T/C cg03465714 chr1:152285911 FLG -0.45 -5.56 -0.32 6.52e-8 Atopic dermatitis; CESC cis rs12701220 0.689 rs12701824 chr7:1102364 G/A cg26769984 chr7:1090371 C7orf50 0.59 5.84 0.34 1.5e-8 Bronchopulmonary dysplasia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06852250 chr1:171750693 METTL13 0.44 6.06 0.35 4.74e-9 Gut microbiota (bacterial taxa); CESC cis rs6121246 0.559 rs1062794 chr20:30381758 G/C cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs7224314 1.000 rs62084078 chr17:65386886 T/C cg01507342 chr17:65387096 PITPNC1 -0.47 -5.66 -0.33 3.86e-8 Diisocyanate-induced asthma; CESC cis rs992157 0.735 rs13388024 chr2:219097773 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.67 9.4 0.5 2.62e-18 Colorectal cancer; CESC cis rs4803468 0.904 rs60781668 chr19:41944842 A/T cg09537434 chr19:41945824 ATP5SL 1.06 19.74 0.77 5.61e-54 Height; CESC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Parkinson's disease; CESC cis rs72627123 0.656 rs75646425 chr14:74529433 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.36 0.31 1.81e-7 Morning vs. evening chronotype; CESC cis rs3806843 0.657 rs2563283 chr5:140105978 C/A cg16179182 chr5:140090404 VTRNA1-1 0.42 5.51 0.32 8.6e-8 Depressive symptoms (multi-trait analysis); CESC cis rs11098499 0.954 rs2306455 chr4:120421969 G/A cg24375607 chr4:120327624 NA 0.46 5.66 0.33 3.87e-8 Corneal astigmatism; CESC cis rs765787 0.530 rs2554456 chr15:45521138 A/C cg24006582 chr15:45444508 DUOX1 -0.57 -6.9 -0.39 3.81e-11 Uric acid levels; CESC cis rs4664308 0.935 rs877200 chr2:160903723 G/C cg03641300 chr2:160917029 PLA2R1 -0.65 -9.79 -0.52 1.63e-19 Idiopathic membranous nephropathy; CESC cis rs2016266 0.784 rs12424778 chr12:53737840 A/T cg26875137 chr12:53738046 NA 0.36 5.24 0.31 3.23e-7 Bone mineral density (spine);Bone mineral density; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg09061317 chr1:28995172 GMEB1 -0.54 -6.25 -0.36 1.64e-9 Gut microbiota (bacterial taxa); CESC cis rs2455799 0.613 rs6772879 chr3:15741793 G/A cg16303742 chr3:15540471 COLQ -0.34 -5.33 -0.31 2.12e-7 Mean platelet volume; CESC cis rs7584330 0.666 rs72620817 chr2:238353661 C/T cg14458575 chr2:238380390 NA 0.84 10.63 0.55 3.16e-22 Prostate cancer; CESC cis rs34779708 0.931 rs4934711 chr10:35360310 G/A cg03585969 chr10:35415529 CREM 0.76 9.9 0.52 7.07e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs3942852 0.568 rs1039484 chr11:48097948 A/G cg15704280 chr7:45808275 SEPT13 -0.72 -9.38 -0.5 3.02e-18 Acute lymphoblastic leukemia (childhood); CESC cis rs1256061 0.624 rs1152578 chr14:64697037 T/C cg21174375 chr14:64681225 SYNE2 0.48 6.36 0.36 8.86e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs798766 0.779 rs55895920 chr4:1735930 C/T cg05874882 chr4:1763078 NA -0.56 -7.3 -0.41 3.31e-12 Bladder cancer;Urinary bladder cancer; CESC cis rs1413885 0.525 rs1334878 chr1:65846124 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.47 6.19 0.36 2.29e-9 Anticoagulant levels; CESC cis rs4629180 0.540 rs6747670 chr2:102130368 T/C cg04415270 chr2:102091202 RFX8 -0.31 -5.27 -0.31 2.85e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg20887711 chr4:1340912 KIAA1530 0.44 5.95 0.34 8.58e-9 Longevity; CESC trans rs1908814 0.516 rs10113062 chr8:11793249 A/G cg15556689 chr8:8085844 FLJ10661 0.5 6.13 0.35 3.13e-9 Neuroticism; CESC cis rs7208859 0.623 rs55724095 chr17:29153058 A/G cg19761014 chr17:28927070 LRRC37B2 0.72 5.91 0.34 1.03e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9303401 0.614 rs8081058 chr17:57160513 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.88 11.1 0.56 8.94e-24 Cognitive test performance; CESC cis rs977987 0.750 rs4888406 chr16:75432334 G/T cg03315344 chr16:75512273 CHST6 0.39 5.71 0.33 2.98e-8 Dupuytren's disease; CESC cis rs9486715 0.867 rs4131519 chr6:96964939 G/A cg18709589 chr6:96969512 KIAA0776 0.47 6.59 0.38 2.32e-10 Headache; CESC cis rs7918232 0.941 rs788220 chr10:27447205 T/C cg14240646 chr10:27532245 ACBD5 0.68 6.45 0.37 5.14e-10 Breast cancer; CESC cis rs10489202 1.000 rs4656564 chr1:167928992 T/C cg24449463 chr1:168025552 DCAF6 -0.45 -5.26 -0.31 3.02e-7 Schizophrenia; CESC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg13393036 chr8:95962371 TP53INP1 -0.55 -12.25 -0.6 1.25e-27 Type 2 diabetes; CESC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg09177884 chr7:1199841 ZFAND2A -0.54 -7.08 -0.4 1.29e-11 Longevity;Endometriosis; CESC cis rs4148883 0.675 rs10000357 chr4:100099942 G/C cg13256891 chr4:100009986 ADH5 0.53 6.93 0.39 3.23e-11 Alcohol dependence; CESC cis rs1506636 1.000 rs1911145 chr7:123363658 A/G cg03229431 chr7:123269106 ASB15 -0.52 -6.91 -0.39 3.58e-11 Plateletcrit;Platelet count; CESC cis rs10484885 0.775 rs55926724 chr6:90417450 A/C cg13799429 chr6:90582589 CASP8AP2 -0.72 -8.14 -0.45 1.6e-14 QRS interval (sulfonylurea treatment interaction); CESC cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg11502198 chr6:26597334 ABT1 0.49 5.14 0.3 5.26e-7 Intelligence (multi-trait analysis); CESC cis rs4481887 0.893 rs6681339 chr1:248482761 C/G cg00666640 chr1:248458726 OR2T12 0.34 5.64 0.33 4.3e-8 Common traits (Other); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05491930 chr6:99872786 SFRS18 -0.45 -7.27 -0.41 3.99e-12 Gambling; CESC cis rs7917772 0.536 rs3961456 chr10:104425304 A/T cg22532475 chr10:104410764 TRIM8 0.41 6.63 0.38 1.84e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs17854409 1.000 rs66634465 chr20:61482306 C/T cg05147244 chr20:61493195 TCFL5 0.94 6.28 0.36 1.34e-9 Obesity-related traits; CESC cis rs7772486 0.790 rs2814880 chr6:146208937 T/G cg23711669 chr6:146136114 FBXO30 0.92 13.39 0.64 1.41e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs911555 0.723 rs6575982 chr14:103862681 G/A cg12935359 chr14:103987150 CKB 0.62 8.89 0.48 9.4e-17 Intelligence (multi-trait analysis); CESC cis rs3892630 1.000 rs3892630 chr19:33181484 A/G cg22980127 chr19:33182716 NUDT19 -1.04 -12.0 -0.59 8.48e-27 Red blood cell traits; CESC cis rs858239 0.669 rs1618339 chr7:23229774 T/C cg23682824 chr7:23144976 KLHL7 0.46 6.37 0.36 8.19e-10 Cerebrospinal fluid biomarker levels; CESC cis rs9303401 0.592 rs12936771 chr17:56725052 T/C cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.13 0.63 1.12e-30 Cognitive test performance; CESC cis rs7259376 0.782 rs113181884 chr19:22586084 A/C cg02657401 chr19:22469223 NA 0.27 5.33 0.31 2.13e-7 Menopause (age at onset); CESC cis rs1801251 0.574 rs2250660 chr2:233752551 G/C cg08000102 chr2:233561755 GIGYF2 -0.49 -6.46 -0.37 4.92e-10 Coronary artery disease; CESC cis rs1371867 0.810 rs2860518 chr8:101238120 G/T cg11906718 chr8:101322791 RNF19A -0.42 -5.41 -0.32 1.44e-7 Atrioventricular conduction; CESC cis rs7647973 0.626 rs1996663 chr3:49878264 C/G cg07636037 chr3:49044803 WDR6 -0.5 -6.07 -0.35 4.44e-9 Menarche (age at onset); CESC cis rs962856 0.619 rs6731934 chr2:67559553 A/G cg09028215 chr2:67624308 ETAA1 -0.46 -5.56 -0.32 6.51e-8 Pancreatic cancer; CESC cis rs2262909 0.925 rs56073035 chr19:22276298 C/G cg11619707 chr19:22235551 ZNF257 0.35 5.76 0.33 2.38e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs2733201 1.000 rs2114421 chr15:44313055 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -5.16 -0.3 4.75e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs6433857 0.594 rs10202422 chr2:181524944 C/T cg23363182 chr2:181467187 NA -0.46 -6.23 -0.36 1.85e-9 Body mass index; CESC cis rs727505 1.000 rs28622327 chr7:124526213 C/T cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15653194 chr7:2559473 LFNG 0.53 6.0 0.35 6.56e-9 Gut microbiome composition (summer); CESC cis rs11608355 0.508 rs11066411 chr12:109804194 A/G cg19025524 chr12:109796872 NA -0.5 -6.3 -0.36 1.25e-9 Neuroticism; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19455953 chr2:207630073 FASTKD2;MDH1B -0.42 -6.18 -0.35 2.35e-9 Gambling; CESC cis rs7520050 0.778 rs3014238 chr1:46090214 A/G cg24296786 chr1:45957014 TESK2 0.47 6.03 0.35 5.36e-9 Red blood cell count;Reticulocyte count; CESC trans rs17536732 0.685 rs77388367 chr4:162856790 G/A cg12177677 chr2:158300475 CYTIP -0.63 -6.2 -0.36 2.17e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs12200560 0.505 rs2387378 chr6:97077504 C/A cg06623918 chr6:96969491 KIAA0776 0.5 6.42 0.37 6.42e-10 Coronary heart disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25730717 chr7:148726076 PDIA4 0.66 7.81 0.43 1.35e-13 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4561483 0.619 rs12597429 chr16:12062396 A/G cg08843971 chr16:11963173 GSPT1 -0.39 -5.35 -0.31 1.88e-7 Testicular germ cell tumor; CESC cis rs12325245 0.536 rs71389028 chr16:58663260 G/A cg01152986 chr16:58549298 SETD6 0.86 5.07 0.3 7.43e-7 Schizophrenia; CESC trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21659725 chr3:3221576 CRBN -0.83 -13.55 -0.64 3.87e-32 Intelligence (multi-trait analysis); CESC cis rs2486288 0.656 rs12915314 chr15:45551491 C/G cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg21770322 chr7:97807741 LMTK2 0.55 8.18 0.45 1.17e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs28829049 0.535 rs12565185 chr1:19498309 G/A cg13387374 chr1:19411106 UBR4 0.43 5.44 0.32 1.2e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs116095464 0.558 rs7715108 chr5:264661 A/G cg22857025 chr5:266934 NA -1.3 -18.55 -0.75 8.05e-50 Breast cancer; CESC cis rs1707322 0.650 rs4553239 chr1:46150486 C/A cg03146154 chr1:46216737 IPP 0.82 11.61 0.58 1.79e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2243480 1.000 rs781149 chr7:65481284 C/T cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC cis rs4474465 0.850 rs7936232 chr11:78266602 A/G cg27205649 chr11:78285834 NARS2 0.45 5.57 0.32 6.11e-8 Alzheimer's disease (survival time); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08874067 chr13:19449177 NA -0.48 -6.65 -0.38 1.7e-10 Gut microbiota (bacterial taxa); CESC cis rs7605827 0.930 rs4668903 chr2:15530051 C/G cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg09177884 chr7:1199841 ZFAND2A -0.65 -8.72 -0.47 3.21e-16 Longevity;Endometriosis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20713439 chr5:140027088 NDUFA2;IK -0.44 -6.35 -0.36 9.51e-10 Gambling; CESC cis rs11690935 0.632 rs6433323 chr2:172873060 A/G cg13550731 chr2:172543902 DYNC1I2 -0.48 -6.81 -0.39 6.61e-11 Schizophrenia; CESC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg22800045 chr5:56110881 MAP3K1 0.62 7.98 0.44 4.48e-14 Initial pursuit acceleration; CESC cis rs2011503 0.941 rs10403273 chr19:19372968 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.51 0.32 8.53e-8 Bipolar disorder; CESC trans rs877282 1.000 rs12219807 chr10:772870 A/C cg22713356 chr15:30763199 NA 1.12 11.31 0.57 1.87e-24 Uric acid levels; CESC cis rs6987853 0.787 rs1343874 chr8:42424746 C/T cg09913449 chr8:42400586 C8orf40 0.46 7.77 0.43 1.72e-13 Mean corpuscular hemoglobin concentration; CESC cis rs2282802 0.685 rs6867870 chr5:139641896 C/A cg26211634 chr5:139558579 C5orf32 0.53 7.66 0.43 3.55e-13 Intelligence (multi-trait analysis); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05879720 chr5:154135170 LARP1 -0.48 -6.14 -0.35 3.07e-9 Asthma; CESC cis rs3733585 0.673 rs7434391 chr4:9967682 C/G cg00071950 chr4:10020882 SLC2A9 -0.7 -11.44 -0.58 6.69e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8017423 0.967 rs11628881 chr14:90713833 C/T cg14092571 chr14:90743983 NA -0.58 -8.72 -0.47 3.01e-16 Mortality in heart failure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09902448 chr6:158454220 SYNJ2 -0.59 -6.54 -0.37 3.22e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs2224120 chr6:146343280 A/C cg23711669 chr6:146136114 FBXO30 0.86 12.49 0.61 1.81e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg24578937 chr1:2090814 PRKCZ 0.34 6.06 0.35 4.68e-9 Height; CESC cis rs1976403 0.633 rs1780324 chr1:21821757 A/G cg04349561 chr1:21808255 NBPF3 -0.38 -5.44 -0.32 1.22e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7605827 0.897 rs12692271 chr2:15640317 T/C cg19274914 chr2:15703543 NA 0.36 6.32 0.36 1.13e-9 Educational attainment (years of education); CESC cis rs9815354 0.812 rs73069208 chr3:41939198 C/T cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs28830936 0.966 rs2303518 chr15:42109975 T/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.41 -5.9 -0.34 1.13e-8 Diastolic blood pressure; CESC cis rs6831352 0.819 rs1230155 chr4:99989259 C/T cg13256891 chr4:100009986 ADH5 0.67 8.0 0.44 3.87e-14 Alcohol dependence; CESC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.99 -0.56 2.21e-23 Alzheimer's disease; CESC cis rs2072732 0.768 rs12045368 chr1:2960192 A/G cg15211996 chr1:2936768 ACTRT2 0.34 5.45 0.32 1.18e-7 Plateletcrit; CESC cis rs12142240 0.659 rs1984491 chr1:46858607 T/G cg10495392 chr1:46806563 NSUN4 0.56 6.17 0.35 2.61e-9 Menopause (age at onset); CESC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg22105103 chr4:187893119 NA 0.51 7.69 0.43 2.88e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27037969 chr12:125549952 AACS -0.43 -6.12 -0.35 3.39e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1847202 0.859 rs6771288 chr3:72939471 A/G cg25664220 chr3:72788482 NA -0.4 -6.04 -0.35 5.12e-9 Motion sickness; CESC cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg26597838 chr10:835615 NA 0.87 9.13 0.49 1.86e-17 Eosinophil percentage of granulocytes; CESC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg23985595 chr17:80112537 CCDC57 0.41 6.42 0.37 6.41e-10 Life satisfaction; CESC cis rs2880765 0.545 rs11631739 chr15:86012578 T/C cg19183879 chr15:85880815 NA -0.31 -5.77 -0.33 2.24e-8 Coronary artery disease; CESC cis rs6714710 0.535 rs13006932 chr2:98370698 T/A cg26665480 chr2:98280029 ACTR1B 0.62 8.32 0.45 4.84e-15 Posterior cortical atrophy and Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11553177 chr17:26988816 SUPT6H;SDF2 0.65 7.68 0.43 3.16e-13 Gut microbiome composition (summer); CESC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg27121462 chr16:89883253 FANCA 0.77 11.14 0.56 6.73e-24 Vitiligo; CESC cis rs3096299 0.967 rs28689480 chr16:89460093 T/C cg00750074 chr16:89608354 SPG7 -0.39 -5.41 -0.32 1.41e-7 Multiple myeloma (IgH translocation); CESC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg05368731 chr17:41323189 NBR1 0.79 11.1 0.56 8.99e-24 Menopause (age at onset); CESC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg05332525 chr7:65337924 VKORC1L1 0.45 5.32 0.31 2.19e-7 Aortic root size; CESC cis rs7191439 0.728 rs4238687 chr16:88788903 T/G cg02389323 chr16:88786976 FAM38A 1.02 8.35 0.46 3.8e-15 Plateletcrit; CESC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg07167872 chr1:205819463 PM20D1 0.76 12.94 0.62 5.37e-30 Menarche (age at onset); CESC cis rs453301 0.658 rs9329175 chr8:8866661 C/T cg15556689 chr8:8085844 FLJ10661 -0.46 -5.41 -0.32 1.38e-7 Joint mobility (Beighton score); CESC cis rs5769765 0.908 rs9616370 chr22:50306316 A/G cg02269571 chr22:50332266 NA 0.49 5.91 0.34 1.07e-8 Schizophrenia; CESC cis rs17431357 0.609 rs73230305 chr12:120984775 C/T cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs1568889 1.000 rs12794100 chr11:28332785 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 9.78 0.51 1.76e-19 Bipolar disorder; CESC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg24562669 chr7:97807699 LMTK2 0.47 6.73 0.38 1.07e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs13256369 0.708 rs11783670 chr8:8559394 G/A cg18904891 chr8:8559673 CLDN23 0.72 8.02 0.44 3.5e-14 Obesity-related traits; CESC cis rs66573146 0.572 rs67750430 chr4:6957266 T/G cg00086871 chr4:6988644 TBC1D14 1.03 6.77 0.38 8.47e-11 Granulocyte percentage of myeloid white cells; CESC cis rs941873 0.772 rs7920127 chr10:81122914 T/C cg11057378 chr10:81107060 PPIF 0.35 5.67 0.33 3.7e-8 Height; CESC cis rs4843747 0.671 rs9921236 chr16:88117015 G/T cg03395651 chr16:88107091 BANP 0.49 5.59 0.32 5.52e-8 Menopause (age at onset); CESC cis rs2832077 0.505 rs9305386 chr21:30386751 A/G cg03476357 chr21:30257390 N6AMT1 0.56 5.32 0.31 2.21e-7 Cognitive test performance; CESC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg02951883 chr7:2050386 MAD1L1 -0.49 -6.55 -0.37 3.01e-10 Bipolar disorder and schizophrenia; CESC cis rs9300255 0.596 rs10734901 chr12:123743447 G/A cg19016782 chr12:123741754 C12orf65 -0.38 -5.73 -0.33 2.74e-8 Neutrophil percentage of white cells; CESC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg02951883 chr7:2050386 MAD1L1 -0.48 -6.24 -0.36 1.71e-9 Bipolar disorder and schizophrenia; CESC trans rs208520 0.690 rs7739253 chr6:66861052 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.92 -0.62 6e-30 Exhaled nitric oxide output; CESC cis rs12791968 0.527 rs4755924 chr11:45013328 A/G cg11846598 chr11:44996168 LOC221122 -0.53 -6.1 -0.35 3.84e-9 Inhibitory control; CESC cis rs10779751 0.922 rs2295079 chr1:11322565 C/G cg08854313 chr1:11322531 MTOR 0.92 14.5 0.67 1.74e-35 Body mass index; CESC cis rs9916302 0.706 rs9944459 chr17:37484185 T/C cg07936489 chr17:37558343 FBXL20 0.94 10.63 0.55 3.23e-22 Glomerular filtration rate (creatinine); CESC cis rs3008870 0.959 rs56707923 chr1:67388016 T/C cg02640540 chr1:67518911 SLC35D1 0.48 5.19 0.3 4.09e-7 Lymphocyte percentage of white cells; CESC cis rs67311347 1.000 rs9865348 chr3:40397658 A/C cg24209194 chr3:40518798 ZNF619 0.42 5.26 0.31 3.05e-7 Renal cell carcinoma; CESC trans rs61931739 0.500 rs34061369 chr12:34519283 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.31e-22 Morning vs. evening chronotype; CESC cis rs933688 1.000 rs10073657 chr5:90689749 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.16 15.41 0.69 1.04e-38 Smoking behavior; CESC cis rs2573652 1.000 rs2727199 chr15:100514417 C/T cg00587665 chr15:100533223 ADAMTS17 -0.41 -6.46 -0.37 4.99e-10 Height; CESC cis rs7267979 0.816 rs1044573 chr20:25206654 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.68 11.27 0.57 2.52e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs3784262 0.934 rs4646611 chr15:58265083 T/C cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.27 -0.31 2.83e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs8053891 0.756 rs35259348 chr16:72003952 G/C cg04254540 chr16:71951199 KIAA0174 -0.43 -5.17 -0.3 4.7e-7 Coronary artery disease; CESC cis rs938554 0.578 rs7663032 chr4:9993838 C/T cg11266682 chr4:10021025 SLC2A9 0.51 7.58 0.42 5.78e-13 Blood metabolite levels; CESC cis rs5769765 1.000 rs5770741 chr22:50270215 A/G cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs909674 0.515 rs9611170 chr22:39784845 G/C cg05872129 chr22:39784769 NA -0.88 -12.46 -0.61 2.31e-28 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07183060 chr2:32288561 SPAST 0.64 8.0 0.44 3.94e-14 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs7503542 chr17:29073830 A/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4722166 0.695 rs56061963 chr7:22800397 T/C cg13104385 chr7:22767384 IL6 0.38 5.59 0.32 5.64e-8 Lung cancer; CESC cis rs568617 0.626 rs78028320 chr11:65582015 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.72 6.11 0.35 3.48e-9 Crohn's disease; CESC cis rs1950626 0.833 rs35436326 chr14:101396148 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.78 10.03 0.52 2.73e-20 Pelvic organ prolapse (moderate/severe); CESC cis rs12291225 0.637 rs8570 chr11:14300759 C/G cg19336497 chr11:14380999 RRAS2 -0.37 -5.31 -0.31 2.32e-7 Sense of smell; CESC trans rs11088226 0.681 rs2833899 chr21:33933263 T/C cg09050820 chr6:167586206 TCP10L2 0.84 7.8 0.43 1.41e-13 Gastritis; CESC cis rs72781680 1.000 rs72798418 chr2:24188922 A/G cg08917208 chr2:24149416 ATAD2B 0.94 8.54 0.46 1.09e-15 Lymphocyte counts; CESC cis rs1832871 0.616 rs55675950 chr6:158773994 T/A cg07165851 chr6:158734300 TULP4 0.59 6.34 0.36 1.01e-9 Height; CESC cis rs6460942 0.908 rs75704904 chr7:12233583 G/A cg06484146 chr7:12443880 VWDE -0.47 -5.22 -0.31 3.54e-7 Coronary artery disease; CESC cis rs11252926 0.673 rs816620 chr10:645916 A/G cg08603382 chr10:743973 NA -0.39 -5.4 -0.32 1.45e-7 Psychosis in Alzheimer's disease; CESC cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg10645314 chr2:3704589 ALLC -0.5 -5.24 -0.31 3.22e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs9863 0.862 rs6488912 chr12:124442752 T/C cg00084347 chr12:124393913 DNAH10 0.27 5.32 0.31 2.17e-7 White blood cell count; CESC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.33 0.5 4.3e-18 Age-related macular degeneration (geographic atrophy); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15450734 chr14:103541957 NA 0.59 7.87 0.44 8.79e-14 Gut microbiota (bacterial taxa); CESC cis rs11785400 1.000 rs11776301 chr8:143737142 A/G cg10596483 chr8:143751796 JRK 0.43 5.66 0.33 4.01e-8 Schizophrenia; CESC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg08736216 chr1:53307985 ZYG11A -0.44 -7.39 -0.41 1.95e-12 Monocyte count; CESC cis rs2304069 0.954 rs2340463 chr5:149409294 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.9 11.22 0.57 3.6e-24 HIV-1 control; CESC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg17294928 chr15:75287854 SCAMP5 0.49 6.42 0.37 6.42e-10 Breast cancer; CESC cis rs9913156 0.589 rs7213481 chr17:4547906 C/T cg00122941 chr17:4613640 ARRB2 0.86 9.95 0.52 5.12e-20 Lymphocyte counts; CESC cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.91e-28 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.807 rs2838328 chr21:45023234 G/C cg21573476 chr21:45109991 RRP1B -0.44 -6.18 -0.35 2.47e-9 Mean corpuscular volume; CESC cis rs7542091 0.506 rs992976 chr1:210066658 A/T cg22029157 chr1:209979665 IRF6 -0.42 -6.34 -0.36 9.83e-10 Monobrow; CESC cis rs829883 1.000 rs1347956 chr12:98889564 A/G cg25150519 chr12:98850993 NA 0.7 9.62 0.51 5.65e-19 Colorectal adenoma (advanced); CESC cis rs7202877 0.656 rs8048677 chr16:75392028 C/G cg04384234 chr16:75411784 CFDP1 -0.47 -5.73 -0.33 2.72e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs2651899 0.867 rs2742675 chr1:3079905 A/G cg07622451 chr1:3079886 PRDM16 0.31 5.64 0.33 4.34e-8 Migraine; CESC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg00784671 chr22:46762841 CELSR1 -0.48 -5.51 -0.32 8.51e-8 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 0.871 rs16921952 chr8:58163317 A/T cg22535103 chr8:58192502 C8orf71 -0.87 -11.25 -0.57 3e-24 Developmental language disorder (linguistic errors); CESC cis rs9815354 1.000 rs9824731 chr3:41889698 G/T cg03022575 chr3:42003672 ULK4 0.58 5.94 0.34 9.04e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg02807482 chr3:125708958 NA -0.4 -5.24 -0.31 3.28e-7 Blood pressure (smoking interaction); CESC cis rs10089 0.953 rs1036171 chr5:127402798 C/T cg19767477 chr5:127420684 SLC12A2 -0.4 -5.28 -0.31 2.63e-7 Ileal carcinoids; CESC cis rs2455799 0.593 rs13085352 chr3:15914845 T/C cg09340198 chr3:15902540 ANKRD28 -0.32 -5.1 -0.3 6.52e-7 Mean platelet volume; CESC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg18758796 chr5:131593413 PDLIM4 -0.43 -5.96 -0.34 8.15e-9 Blood metabolite levels; CESC cis rs7107174 0.892 rs1017907 chr11:77959124 A/T cg02023728 chr11:77925099 USP35 0.43 6.07 0.35 4.5e-9 Testicular germ cell tumor; CESC cis rs7727544 0.735 rs273914 chr5:131660431 A/T cg24060327 chr5:131705240 SLC22A5 -0.68 -9.14 -0.49 1.69e-17 Blood metabolite levels; CESC cis rs3793683 0.545 rs12784407 chr10:134589631 A/G cg27297192 chr10:134578999 INPP5A 0.39 5.14 0.3 5.28e-7 Migraine; CESC cis rs2274273 0.662 rs67588230 chr14:55667030 C/T cg04306507 chr14:55594613 LGALS3 0.31 5.33 0.31 2.11e-7 Protein biomarker; CESC cis rs7772486 0.790 rs9497435 chr6:146265340 C/A cg05347473 chr6:146136440 FBXO30 -0.52 -6.88 -0.39 4.23e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs826838 0.935 rs1160162 chr12:38959795 G/A cg26384229 chr12:38710491 ALG10B 0.82 14.16 0.66 2.77e-34 Heart rate; CESC cis rs11098499 0.863 rs7699064 chr4:120428309 A/G cg09307838 chr4:120376055 NA -0.95 -13.35 -0.63 1.95e-31 Corneal astigmatism; CESC cis rs7914558 1.000 rs4917994 chr10:104811699 C/T cg08650961 chr10:104748594 CNNM2 0.31 5.19 0.3 4.18e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27507545 chr10:103880405 LDB1 0.49 6.31 0.36 1.18e-9 Gut microbiota (bacterial taxa); CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg25934064 chr3:52569026 NT5DC2 0.28 5.78 0.33 2.05e-8 Electroencephalogram traits; CESC cis rs138880 0.542 rs9616210 chr22:50317346 C/T cg02269571 chr22:50332266 NA -0.65 -6.12 -0.35 3.3e-9 Schizophrenia; CESC cis rs17407555 0.821 rs4292329 chr4:10144459 C/G cg00071950 chr4:10020882 SLC2A9 -0.57 -5.63 -0.33 4.7e-8 Schizophrenia (age at onset); CESC cis rs11122272 0.735 rs2486740 chr1:231517552 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg07092213 chr7:1199455 ZFAND2A -0.45 -6.24 -0.36 1.71e-9 Longevity;Endometriosis; CESC cis rs9916302 0.904 rs8077104 chr17:37530510 A/G cg07936489 chr17:37558343 FBXL20 0.82 11.97 0.59 1.11e-26 Glomerular filtration rate (creatinine); CESC cis rs4835473 0.689 rs1849123 chr4:144899648 T/G cg25736465 chr4:144833511 NA 0.4 6.13 0.35 3.19e-9 Immature fraction of reticulocytes; CESC cis rs1620921 0.505 rs2115869 chr6:161207892 C/T cg01280913 chr6:161186852 NA -0.36 -5.29 -0.31 2.53e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs10088262 0.629 rs6990565 chr8:124785645 C/A cg20713898 chr8:124780851 FAM91A1 -0.65 -8.55 -0.47 9.93e-16 Pancreatic cancer; CESC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.35 -0.36 9.12e-10 Bipolar disorder; CESC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg22920501 chr2:26401640 FAM59B -0.86 -10.09 -0.53 1.75e-20 Gut microbiome composition (summer); CESC cis rs761746 0.739 rs5998054 chr22:31994406 C/A cg25791279 chr22:32026902 PISD 0.62 7.14 0.4 9.13e-12 Intelligence; CESC cis rs400736 0.602 rs10864330 chr1:8168564 C/T cg25007680 chr1:8021821 PARK7 -0.57 -7.67 -0.43 3.36e-13 Response to antidepressants and depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26595336 chr15:82338380 MEX3B 0.6 6.71 0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs3820068 0.581 rs58567918 chr1:15925823 A/G cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC trans rs11098499 0.865 rs10213221 chr4:120255926 G/A cg25214090 chr10:38739885 LOC399744 0.64 8.96 0.48 5.79e-17 Corneal astigmatism; CESC cis rs1256061 0.669 rs1256065 chr14:64698932 G/T cg23250157 chr14:64679961 SYNE2 0.52 7.36 0.41 2.37e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6963495 0.769 rs11556986 chr7:105177041 A/T cg02135003 chr7:105160482 PUS7 -0.43 -5.46 -0.32 1.12e-7 Bipolar disorder (body mass index interaction); CESC cis rs1707322 0.721 rs11211151 chr1:46112752 T/C cg06784218 chr1:46089804 CCDC17 0.43 7.4 0.41 1.77e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11785400 0.793 rs750530 chr8:143744931 G/A cg10596483 chr8:143751796 JRK 0.42 5.34 0.31 1.97e-7 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15044954 chr7:89874365 C7orf63 0.48 6.02 0.35 5.76e-9 Gut microbiota (bacterial taxa); CESC cis rs2354432 0.607 rs57078845 chr1:146722222 G/A cg25205988 chr1:146714368 CHD1L -0.97 -7.86 -0.43 9.67e-14 Mitochondrial DNA levels; CESC cis rs7084402 0.967 rs1658491 chr10:60281354 C/T cg07615347 chr10:60278583 BICC1 -0.59 -9.48 -0.5 1.48e-18 Refractive error; CESC cis rs2274273 0.686 rs2296489 chr14:55624977 T/C cg04306507 chr14:55594613 LGALS3 0.31 5.26 0.31 2.99e-7 Protein biomarker; CESC cis rs1707322 0.964 rs12067716 chr1:46434428 T/A cg06784218 chr1:46089804 CCDC17 0.36 6.06 0.35 4.65e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25291941 chr8:99129319 POP1;HRSP12 0.66 7.55 0.42 6.97e-13 Gut microbiome composition (summer); CESC cis rs10789491 0.953 rs11211337 chr1:47133811 T/C cg15501359 chr1:47185051 KIAA0494 0.8 8.59 0.47 7.41e-16 Response to hepatitis C treatment; CESC cis rs9341808 0.667 rs2322632 chr6:80845608 G/A cg08355045 chr6:80787529 NA 0.32 5.1 0.3 6.44e-7 Sitting height ratio; CESC cis rs611744 0.647 rs702808 chr8:109252554 T/C cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.65e-8 Dupuytren's disease; CESC cis rs3820068 0.581 rs72645893 chr1:15930943 C/G cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs4953318 0.619 rs10198247 chr2:46362677 C/T cg12428440 chr2:46370979 PRKCE -0.48 -6.54 -0.37 3.08e-10 Red blood cell count;Hematocrit;Red blood cell traits; CESC cis rs62408225 1.000 rs969577 chr6:90982387 T/C cg06866423 chr6:90926672 BACH2 0.43 5.25 0.31 3.17e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1348850 0.914 rs12616443 chr2:178315751 A/G cg22681709 chr2:178499509 PDE11A -0.39 -5.78 -0.33 2.1e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.36 0.31 1.85e-7 Bipolar disorder; CESC cis rs7618501 1.000 rs7634902 chr3:49762662 G/T cg24308560 chr3:49941425 MST1R 0.5 6.81 0.39 6.39e-11 Intelligence (multi-trait analysis); CESC cis rs4268898 0.516 rs7597149 chr2:24371962 C/T cg06627628 chr2:24431161 ITSN2 0.6 8.31 0.45 5.17e-15 Asthma; CESC cis rs7246865 0.510 rs7253742 chr19:17171689 C/T cg16202187 chr19:17186497 HAUS8;MYO9B -0.49 -6.45 -0.37 5.16e-10 Reticulocyte fraction of red cells; CESC cis rs4969178 0.931 rs3826323 chr17:76400268 C/G cg20026190 chr17:76395443 PGS1 0.46 7.35 0.41 2.41e-12 HDL cholesterol levels; CESC cis rs9948 0.786 rs62152775 chr2:97448474 G/T cg01990225 chr2:97406019 LMAN2L -0.92 -7.51 -0.42 9.04e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs3741151 0.773 rs74881062 chr11:73245769 G/A cg17517138 chr11:73019481 ARHGEF17 1.05 7.72 0.43 2.46e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg26668828 chr6:292823 DUSP22 -0.72 -9.53 -0.51 1.03e-18 Menopause (age at onset); CESC cis rs3820068 0.705 rs4646077 chr1:15827136 C/T cg18192808 chr1:15853278 DNAJC16 0.47 5.78 0.33 2.05e-8 Systolic blood pressure; CESC cis rs72781680 0.652 rs72794281 chr2:23893265 G/A cg08917208 chr2:24149416 ATAD2B 1.19 11.0 0.56 1.91e-23 Lymphocyte counts; CESC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg02269571 chr22:50332266 NA -0.56 -6.99 -0.39 2.26e-11 Schizophrenia; CESC cis rs854765 0.724 rs62072049 chr17:17906520 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.49 6.79 0.38 7.39e-11 Total body bone mineral density; CESC cis rs870825 0.860 rs61165411 chr4:185604461 G/A cg04058563 chr4:185651563 MLF1IP 0.6 5.43 0.32 1.28e-7 Blood protein levels; CESC cis rs703842 0.616 rs10783850 chr12:58229377 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.58 6.84 0.39 5.5e-11 Multiple sclerosis; CESC cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.4e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg27266027 chr21:40555129 PSMG1 0.46 5.59 0.32 5.74e-8 Cognitive function; CESC cis rs4423214 0.559 rs11234042 chr11:71239086 C/A cg05163923 chr11:71159392 DHCR7 -0.57 -6.18 -0.36 2.35e-9 Vitamin D levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04180460 chr3:41240962 CTNNB1 -0.41 -6.1 -0.35 3.66e-9 Gambling; CESC cis rs67478160 0.529 rs12880413 chr14:104267407 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.09 -0.4 1.2e-11 Schizophrenia; CESC cis rs12900413 0.603 rs2118848 chr15:90302503 T/C cg24249390 chr15:90295951 MESP1 -0.38 -5.03 -0.3 9.13e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs9875589 0.509 rs7614591 chr3:14061118 A/T cg19554555 chr3:13937349 NA -0.44 -5.6 -0.33 5.43e-8 Ovarian reserve; CESC cis rs2576037 0.901 rs2576036 chr18:44587102 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.65 9.4 0.5 2.65e-18 Personality dimensions; CESC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.56 0.37 2.75e-10 Prudent dietary pattern; CESC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg24549020 chr5:56110836 MAP3K1 0.57 6.52 0.37 3.46e-10 Initial pursuit acceleration; CESC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg00166722 chr3:10149974 C3orf24 0.49 6.04 0.35 5.24e-9 Alzheimer's disease; CESC cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg21573476 chr21:45109991 RRP1B 0.52 7.89 0.44 8.04e-14 Mean corpuscular volume; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg03670158 chr17:41323431 NBR1 0.47 6.25 0.36 1.63e-9 Weight; CESC cis rs9916302 0.904 rs7210488 chr17:37539819 T/G cg07936489 chr17:37558343 FBXL20 0.82 11.85 0.59 2.73e-26 Glomerular filtration rate (creatinine); CESC cis rs7808935 0.591 rs62451117 chr7:27942357 T/C cg05786569 chr7:27702416 HIBADH 0.49 5.46 0.32 1.09e-7 Prostate cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15855450 chr6:26103952 HIST1H4C 0.46 6.01 0.35 6.19e-9 Ulcerative colitis; CESC cis rs11723261 0.621 rs3829 chr4:134851 T/C cg12746427 chr4:53362 ZNF718;ZNF595 0.43 5.08 0.3 7.2e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs10838687 0.736 rs2279238 chr11:47282024 C/T cg25783544 chr11:47291846 MADD 0.56 6.37 0.36 8.42e-10 Proinsulin levels; CESC cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg01181863 chr3:195395398 SDHAP2 -0.49 -6.01 -0.35 5.97e-9 Pancreatic cancer; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg05564831 chr3:52568323 NT5DC2 0.48 8.16 0.45 1.34e-14 Bipolar disorder; CESC cis rs67478160 0.619 rs12885018 chr14:104273812 A/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.76 0.55 1.22e-22 Schizophrenia; CESC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs67460515 0.563 rs1599388 chr3:160846866 A/G cg03342759 chr3:160939853 NMD3 -0.53 -6.82 -0.39 6.24e-11 Parkinson's disease; CESC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg14393609 chr7:65229607 NA -0.54 -7.31 -0.41 3.09e-12 Aortic root size; CESC cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.94 0.34 8.86e-9 Tonsillectomy; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22834172 chr17:37774349 NA -0.49 -6.4 -0.37 6.99e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.79 0.34 1.94e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs4595586 0.545 rs1375796 chr12:39410592 G/T cg26384229 chr12:38710491 ALG10B 0.61 8.54 0.46 1.07e-15 Morning vs. evening chronotype; CESC cis rs3818285 0.515 rs12258440 chr10:111676799 C/T cg00817464 chr10:111662876 XPNPEP1 -0.51 -7.11 -0.4 1.11e-11 Superior crus of antihelix expression; CESC cis rs7772486 0.686 rs9376956 chr6:145949844 T/C cg23711669 chr6:146136114 FBXO30 0.87 12.67 0.61 4.52e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs12136530 0.774 rs4912097 chr1:19784410 C/G cg01832549 chr1:19774989 CAPZB -0.42 -5.99 -0.35 6.9e-9 Lead levels in blood; CESC cis rs6690583 0.623 rs12041012 chr1:85515644 G/A cg22153463 chr1:85462885 MCOLN2 0.76 7.37 0.41 2.23e-12 Serum sulfate level; CESC cis rs459571 0.959 rs416390 chr9:136908549 C/G cg13789015 chr9:136890014 NCRNA00094 -0.58 -8.34 -0.46 4e-15 Platelet distribution width; CESC cis rs7267979 1.000 rs6115153 chr20:25325567 T/C cg08601574 chr20:25228251 PYGB -0.38 -5.51 -0.32 8.54e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs3008870 1.000 rs2755250 chr1:67495283 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.98 13.07 0.63 1.83e-30 Lymphocyte percentage of white cells; CESC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg17376030 chr22:41985996 PMM1 -0.78 -8.33 -0.46 4.43e-15 Vitiligo; CESC cis rs8060686 0.641 rs12446007 chr16:68189054 C/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.02 -0.35 5.67e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs9303401 0.538 rs10515155 chr17:56481944 A/G cg12560992 chr17:57184187 TRIM37 0.52 5.18 0.3 4.38e-7 Cognitive test performance; CESC cis rs977987 0.815 rs11861810 chr16:75461829 A/G cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.1 0.3 6.46e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.561 rs12453198 chr17:37741879 T/C cg07936489 chr17:37558343 FBXL20 -0.87 -8.8 -0.48 1.82e-16 Glomerular filtration rate (creatinine); CESC cis rs2599510 0.811 rs2710625 chr2:32822957 G/A cg02381751 chr2:32503542 YIPF4 0.48 5.87 0.34 1.3e-8 Interleukin-18 levels; CESC cis rs6087990 0.735 rs6058883 chr20:31365719 C/T cg13636640 chr20:31349939 DNMT3B -0.78 -12.89 -0.62 7.56e-30 Ulcerative colitis; CESC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg11890956 chr21:40555474 PSMG1 -0.66 -9.46 -0.5 1.72e-18 Menarche (age at onset); CESC cis rs6539267 0.885 rs34762209 chr12:106722466 T/C cg00173435 chr12:106696525 TCP11L2 0.51 5.47 0.32 1.05e-7 Tourette syndrome; CESC cis rs494003 1.000 rs72922733 chr11:65520746 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.65 5.08 0.3 7.06e-7 Systemic lupus erythematosus; CESC cis rs7551222 0.752 rs2290854 chr1:204516025 A/G cg20240347 chr1:204465584 NA -0.28 -5.75 -0.33 2.49e-8 Schizophrenia; CESC cis rs9467711 0.606 rs9393713 chr6:26373678 C/T cg14345882 chr6:26364793 BTN3A2 0.57 6.22 0.36 1.92e-9 Autism spectrum disorder or schizophrenia; CESC cis rs1348850 0.914 rs4893961 chr2:178411075 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.72 9.98 0.52 4.07e-20 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2865126 0.743 rs8084621 chr18:10749429 T/C cg21165219 chr18:10698044 FAM38B -0.51 -5.16 -0.3 4.83e-7 Metabolite levels (5-HIAA/ MHPG Ratio); CESC cis rs2295499 0.660 rs11490068 chr4:2639106 A/C cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.19 -0.3 4.18e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs7077164 0.960 rs1227777 chr10:71581131 A/G cg20696214 chr10:71583771 COL13A1 0.47 6.74 0.38 9.88e-11 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs796364 0.760 rs2202922 chr2:200882610 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.84 7.71 0.43 2.62e-13 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18560442 chr1:39174410 NA 0.5 7.0 0.4 2.13e-11 Fibrinogen levels; CESC cis rs4474465 0.688 rs4367973 chr11:78284545 C/A cg27205649 chr11:78285834 NARS2 0.49 6.39 0.37 7.22e-10 Alzheimer's disease (survival time); CESC trans rs10489896 0.541 rs6682410 chr1:234570685 G/A cg23817893 chr11:86085932 CCDC81 -0.45 -6.21 -0.36 2.04e-9 Cognitive test performance; CESC cis rs7561273 0.609 rs2080727 chr2:24350907 A/G cg20701182 chr2:24300061 SF3B14 0.46 5.96 0.34 7.86e-9 Quantitative traits; CESC cis rs2120019 0.935 rs12591119 chr15:75355944 A/G cg09165964 chr15:75287851 SCAMP5 -0.73 -8.47 -0.46 1.7e-15 Blood trace element (Zn levels); CESC cis rs9611565 0.506 rs4822020 chr22:41700203 C/T cg17376030 chr22:41985996 PMM1 0.49 5.43 0.32 1.26e-7 Vitiligo; CESC cis rs2486288 0.656 rs1706770 chr15:45575062 T/C cg21132104 chr15:45694354 SPATA5L1 -0.63 -7.55 -0.42 7.11e-13 Glomerular filtration rate; CESC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs835154 0.845 rs835155 chr5:14875868 A/G cg18064842 chr5:14874549 NA 0.43 6.97 0.39 2.57e-11 Blood metabolite levels; CESC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 12.01 0.59 7.93e-27 Platelet count; CESC cis rs2050392 0.624 rs2489842 chr10:30721991 T/C cg25182066 chr10:30743637 MAP3K8 -0.45 -5.81 -0.34 1.76e-8 Inflammatory bowel disease; CESC cis rs4727027 0.933 rs12532104 chr7:148864233 A/C cg23583168 chr7:148888333 NA -0.81 -12.7 -0.62 3.49e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg19163074 chr7:65112434 INTS4L2 -0.46 -5.1 -0.3 6.4e-7 Aortic root size; CESC cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg11214544 chr1:2391121 NA -0.41 -6.31 -0.36 1.16e-9 Non-obstructive azoospermia; CESC cis rs754466 0.580 rs2579178 chr10:79529215 A/G cg17075019 chr10:79541650 NA 0.83 12.22 0.6 1.52e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg12386194 chr3:101231763 SENP7 0.45 5.71 0.33 3.05e-8 Colorectal cancer; CESC cis rs123509 0.913 rs339685 chr3:42782952 C/G cg12982090 chr3:42733453 KBTBD5 0.72 8.68 0.47 4.15e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs12477438 0.520 rs13035311 chr2:99717322 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.92 15.86 0.7 2.85e-40 Chronic sinus infection; CESC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg12516959 chr21:47718080 NA -0.35 -5.2 -0.3 4.04e-7 Testicular germ cell tumor; CESC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg24675658 chr1:53192096 ZYG11B -0.6 -7.61 -0.42 4.78e-13 Monocyte count; CESC trans rs11674184 0.714 rs16857668 chr2:11723110 G/A cg14768519 chr17:79870056 SIRT7;PCYT2 -0.41 -6.11 -0.35 3.55e-9 Endometriosis; CESC trans rs7618501 0.633 rs2353579 chr3:50027774 C/T cg21659725 chr3:3221576 CRBN 0.5 6.87 0.39 4.44e-11 Intelligence (multi-trait analysis); CESC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg02569458 chr12:86230093 RASSF9 0.54 7.75 0.43 2.02e-13 Major depressive disorder; CESC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg08027265 chr7:2291960 NA -0.42 -6.34 -0.36 9.87e-10 Bipolar disorder and schizophrenia; CESC cis rs9908102 0.746 rs2286340 chr17:12898787 C/G cg26162695 chr17:12921313 ELAC2 0.54 5.73 0.33 2.69e-8 Schizophrenia; CESC trans rs1814175 0.645 rs847635 chr11:49923323 G/A cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg12311346 chr5:56204834 C5orf35 0.54 6.6 0.38 2.25e-10 Coronary artery disease; CESC cis rs863345 0.604 rs10797022 chr1:158494193 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.75e-11 Pneumococcal bacteremia; CESC cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -8.54 -0.46 1.09e-15 Hemoglobin concentration; CESC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg12463550 chr7:65579703 CRCP 0.51 6.36 0.36 8.66e-10 Aortic root size; CESC cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.52 0.46 1.24e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2658782 0.547 rs3020052 chr11:93055184 C/G cg15737290 chr11:93063684 CCDC67 0.54 7.41 0.41 1.68e-12 Pulmonary function decline; CESC cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg12365402 chr11:9010492 NRIP3 -0.45 -7.88 -0.44 8.45e-14 Hemoglobin concentration; CESC cis rs4323050 0.510 rs4273414 chr4:144914295 G/C cg25736465 chr4:144833511 NA 0.43 6.44 0.37 5.61e-10 High light scatter reticulocyte percentage of red cells; CESC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg19774624 chr17:42201019 HDAC5 -0.81 -12.5 -0.61 1.77e-28 Total body bone mineral density; CESC cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg02574844 chr11:5959923 NA -0.44 -5.44 -0.32 1.21e-7 DNA methylation (variation); CESC cis rs9479482 1.000 rs11155696 chr6:150357283 G/A cg03788504 chr6:150331562 NA -0.38 -7.3 -0.41 3.26e-12 Alopecia areata; CESC cis rs1801251 0.963 rs283481 chr2:233648091 A/G cg25237894 chr2:233734115 C2orf82 0.46 7.81 0.43 1.33e-13 Coronary artery disease; CESC cis rs35849525 0.814 rs35491931 chr3:49993462 T/A cg24308560 chr3:49941425 MST1R -0.53 -6.43 -0.37 6.09e-10 Intelligence (multi-trait analysis); CESC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg05564831 chr3:52568323 NT5DC2 0.44 6.46 0.37 4.92e-10 Bipolar disorder; CESC cis rs9611565 0.765 rs132921 chr22:41812044 G/A cg03806693 chr22:41940476 POLR3H 1.04 12.98 0.62 3.76e-30 Vitiligo; CESC cis rs2456568 0.803 rs10831141 chr11:93640728 C/T cg26875233 chr11:93583750 C11orf90 -0.3 -5.19 -0.3 4.16e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg08736216 chr1:53307985 ZYG11A -0.4 -6.5 -0.37 3.9e-10 Monocyte count; CESC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg01416388 chr22:39784598 NA -0.59 -7.37 -0.41 2.23e-12 Intelligence (multi-trait analysis); CESC cis rs8002861 0.846 rs12869521 chr13:44478346 A/G cg14210620 chr13:44453864 C13orf31;CCDC122 -0.43 -5.57 -0.32 6.35e-8 Leprosy; CESC cis rs3026101 0.671 rs3026136 chr17:5310308 G/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01596986 chr13:48611463 NUDT15 0.47 6.63 0.38 1.86e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6963495 0.818 rs73190149 chr7:105152793 C/T cg19920283 chr7:105172520 RINT1 0.69 6.54 0.37 3.09e-10 Bipolar disorder (body mass index interaction); CESC cis rs7267979 0.933 rs2258728 chr20:25276343 G/A cg08601574 chr20:25228251 PYGB 0.38 5.48 0.32 9.97e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs17253792 0.822 rs77315200 chr14:56072643 C/A cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs8141529 0.764 rs5752807 chr22:29223169 A/G cg02153584 chr22:29168773 CCDC117 0.65 9.21 0.49 1.03e-17 Lymphocyte counts; CESC cis rs35849525 0.776 rs7615318 chr3:49987475 C/T cg03060546 chr3:49711283 APEH -0.47 -5.43 -0.32 1.3e-7 Intelligence (multi-trait analysis); CESC cis rs11785400 0.762 rs4401833 chr8:143739731 A/T cg24634471 chr8:143751801 JRK 0.45 5.75 0.33 2.41e-8 Schizophrenia; CESC cis rs7605827 0.930 rs13026732 chr2:15695429 G/A cg19274914 chr2:15703543 NA 0.3 5.34 0.31 2.03e-7 Educational attainment (years of education); CESC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg18758796 chr5:131593413 PDLIM4 -0.4 -5.53 -0.32 7.69e-8 Breast cancer; CESC trans rs9858542 0.953 rs9837027 chr3:49597013 C/T cg21659725 chr3:3221576 CRBN -0.52 -6.35 -0.36 9.31e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2742234 0.955 rs2435385 chr10:43665750 A/G cg07801480 chr10:43725741 RASGEF1A 0.4 5.59 0.32 5.67e-8 Hirschsprung disease; CESC cis rs7474896 0.559 rs1735641 chr10:38184852 C/A cg25427524 chr10:38739819 LOC399744 0.48 5.27 0.31 2.88e-7 Obesity (extreme); CESC cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg18876405 chr7:65276391 NA 0.49 5.39 0.31 1.58e-7 Aortic root size; CESC cis rs7208859 0.623 rs9912283 chr17:29110373 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 6.5 0.37 4.07e-10 LDL cholesterol;Cholesterol, total; CESC cis rs858239 0.730 rs10255155 chr7:23402147 A/T cg23682824 chr7:23144976 KLHL7 -0.39 -5.03 -0.3 9.15e-7 Cerebrospinal fluid biomarker levels; CESC trans rs9951602 0.512 rs1599636 chr18:76643916 G/A cg02800362 chr5:177631904 HNRNPAB 0.62 8.1 0.45 1.96e-14 Obesity-related traits; CESC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.76 -0.51 2.03e-19 Alzheimer's disease; CESC cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg11742103 chr11:62369870 EML3;MTA2 0.57 8.06 0.44 2.69e-14 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs10206020 0.885 rs6746052 chr2:1576811 T/C cg26248373 chr2:1572462 NA -0.59 -6.93 -0.39 3.22e-11 IgG glycosylation; CESC cis rs9908102 0.740 rs56131975 chr17:12912870 T/C cg26162695 chr17:12921313 ELAC2 0.52 5.71 0.33 3.04e-8 Schizophrenia; CESC cis rs1003719 0.628 rs2252402 chr21:38520720 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.44 5.65 0.33 4.14e-8 Eye color traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06866400 chr6:143771904 ADAT2;PEX3 -0.48 -6.84 -0.39 5.57e-11 Fibrinogen levels; CESC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.54 0.37 3.24e-10 Bipolar disorder; CESC cis rs9815354 0.812 rs57809229 chr3:41840162 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7223966 1.000 rs752621 chr17:61901880 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.18 0.35 2.43e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg11764359 chr7:65958608 NA -0.78 -11.32 -0.57 1.76e-24 Aortic root size; CESC cis rs17376456 0.877 rs13156865 chr5:93390908 C/A cg25358565 chr5:93447407 FAM172A 1.11 11.19 0.57 4.5e-24 Diabetic retinopathy; CESC cis rs1008375 0.898 rs4698623 chr4:17594702 T/C cg02297831 chr4:17616191 MED28 0.46 5.68 0.33 3.58e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs561341 1.000 rs576985 chr17:30323323 C/T cg00745463 chr17:30367425 LRRC37B -0.82 -7.51 -0.42 9.09e-13 Hip circumference adjusted for BMI; CESC cis rs11214589 0.774 rs10891544 chr11:113256152 A/C cg14159747 chr11:113255604 NA -0.37 -6.68 -0.38 1.36e-10 Neuroticism; CESC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg05368731 chr17:41323189 NBR1 -0.79 -10.92 -0.56 3.62e-23 Menopause (age at onset); CESC cis rs11030122 0.702 rs10835312 chr11:3950253 G/A cg18678763 chr11:4115507 RRM1 -0.45 -6.05 -0.35 4.94e-9 Mean platelet volume;Platelet distribution width; CESC cis rs73001065 0.901 rs73002956 chr19:19578743 A/G cg03709012 chr19:19516395 GATAD2A 0.98 5.63 0.33 4.53e-8 LDL cholesterol; CESC trans rs801193 1.000 rs3778909 chr7:66255646 G/C cg14393609 chr7:65229607 NA 0.47 6.33 0.36 1.04e-9 Aortic root size; CESC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg00166722 chr3:10149974 C3orf24 0.48 5.92 0.34 9.76e-9 Alzheimer's disease; CESC cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg14345882 chr6:26364793 BTN3A2 0.41 5.12 0.3 5.79e-7 Intelligence (multi-trait analysis); CESC cis rs10504229 0.817 rs55949560 chr8:58167603 T/C cg05313129 chr8:58192883 C8orf71 -0.46 -5.85 -0.34 1.46e-8 Developmental language disorder (linguistic errors); CESC cis rs477895 0.838 rs72922039 chr11:64013116 A/C cg18225595 chr11:63971243 STIP1 0.52 5.29 0.31 2.54e-7 Mean platelet volume; CESC cis rs11252926 0.562 rs11252792 chr10:544369 G/A cg18196295 chr10:418757 DIP2C -0.45 -6.06 -0.35 4.78e-9 Psychosis in Alzheimer's disease; CESC cis rs7223966 1.000 rs7209435 chr17:61712964 T/C cg11494091 chr17:61959527 GH2 0.38 5.44 0.32 1.24e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg20203395 chr5:56204925 C5orf35 -0.39 -5.3 -0.31 2.39e-7 Initial pursuit acceleration; CESC cis rs61776719 0.747 rs28428561 chr1:38434306 G/A cg04673462 chr1:38461896 NA -0.43 -6.48 -0.37 4.47e-10 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25096566 chr6:136871941 MAP7 0.52 6.21 0.36 2.08e-9 Gut microbiome composition (summer); CESC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg22800045 chr5:56110881 MAP3K1 0.59 7.75 0.43 2.03e-13 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05843430 chr2:198299934 SF3B1 0.55 6.06 0.35 4.71e-9 Gut microbiome composition (summer); CESC cis rs208520 0.690 rs207740 chr6:66764132 T/G cg07460842 chr6:66804631 NA 0.96 13.07 0.63 1.89e-30 Exhaled nitric oxide output; CESC cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg05585544 chr11:47624801 NA -0.47 -6.87 -0.39 4.49e-11 Subjective well-being; CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg18765753 chr7:1198926 ZFAND2A -0.44 -5.47 -0.32 1.03e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs1152591 0.524 rs1255990 chr14:64661523 A/G cg21174375 chr14:64681225 SYNE2 -0.56 -7.78 -0.43 1.58e-13 Atrial fibrillation; CESC cis rs11122272 0.735 rs2247132 chr1:231493359 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.59 -0.42 5.45e-13 Hemoglobin concentration; CESC cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 5.16 0.3 4.93e-7 Osteoporosis; CESC cis rs9640161 0.789 rs1464752 chr7:150021284 C/T cg10018233 chr7:150070692 REPIN1 0.43 6.83 0.39 5.68e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg13880726 chr7:1868755 MAD1L1 0.51 6.78 0.38 8e-11 Bipolar disorder and schizophrenia; CESC cis rs4253772 0.530 rs715518 chr22:46754177 C/G cg18190219 chr22:46762943 CELSR1 -0.67 -6.16 -0.35 2.72e-9 LDL cholesterol;Cholesterol, total; CESC cis rs748404 0.578 rs573615 chr15:43614281 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.75 0.47 2.5e-16 Lung cancer; CESC cis rs9486719 1.000 rs12193732 chr6:96942609 G/A cg06623918 chr6:96969491 KIAA0776 -0.83 -8.64 -0.47 5.35e-16 Migraine;Coronary artery disease; CESC cis rs11792861 0.589 rs2176692 chr9:111927723 G/A cg13535736 chr9:111863775 C9orf5 -0.51 -6.52 -0.37 3.44e-10 Menarche (age at onset); CESC cis rs3540 0.597 rs1978149 chr15:91036976 A/G cg22089800 chr15:90895588 ZNF774 0.64 8.75 0.47 2.5e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs11122272 0.735 rs2474634 chr1:231487017 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.29 0.36 1.33e-9 Hemoglobin concentration; CESC cis rs4642101 0.597 rs12638595 chr3:12819281 T/C cg24848339 chr3:12840334 CAND2 0.4 6.14 0.35 2.96e-9 QRS complex (12-leadsum); CESC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg11764359 chr7:65958608 NA 0.8 9.69 0.51 3.4e-19 Aortic root size; CESC cis rs9611565 0.802 rs132916 chr22:41806768 C/G cg06634786 chr22:41940651 POLR3H 0.53 6.1 0.35 3.7e-9 Vitiligo; CESC cis rs2880765 0.835 rs4360875 chr15:86040394 A/G cg10818794 chr15:86012489 AKAP13 -0.34 -5.25 -0.31 3.11e-7 Coronary artery disease; CESC cis rs2880765 0.835 rs11638498 chr15:86023018 T/C cg10818794 chr15:86012489 AKAP13 -0.33 -5.2 -0.3 4.08e-7 Coronary artery disease; CESC trans rs9936075 0.519 rs74010668 chr16:7416136 A/T cg24715815 chr2:183642235 DNAJC10 0.53 6.15 0.35 2.8e-9 Platelet-derived growth factor BB levels; CESC cis rs17376456 0.877 rs10476599 chr5:93383423 A/G cg21475434 chr5:93447410 FAM172A 0.79 6.94 0.39 2.95e-11 Diabetic retinopathy; CESC cis rs473651 0.904 rs10929275 chr2:239323169 A/G cg21699342 chr2:239360505 ASB1 0.51 8.55 0.46 1.03e-15 Multiple system atrophy; CESC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg19318889 chr4:1322082 MAEA -0.49 -6.36 -0.36 8.91e-10 Obesity-related traits; CESC cis rs9640161 0.789 rs28432021 chr7:150046235 G/C cg17279839 chr7:150038598 RARRES2 0.48 5.83 0.34 1.61e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -10.02 -0.52 3.07e-20 Systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02471486 chr8:71016278 NA 0.43 6.03 0.35 5.34e-9 Fibrinogen levels; CESC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg04369109 chr6:150039330 LATS1 -0.4 -5.4 -0.31 1.48e-7 Lung cancer; CESC cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg24110177 chr3:50126178 RBM5 0.52 7.28 0.41 3.76e-12 Intelligence (multi-trait analysis); CESC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.46 -0.32 1.09e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01125366 chr10:72218306 NA 0.51 6.12 0.35 3.34e-9 Gut microbiome composition (summer); CESC cis rs3784262 1.000 rs7165247 chr15:58251786 C/T cg12031962 chr15:58353849 ALDH1A2 0.3 5.04 0.3 8.73e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2249625 1.000 rs1819065 chr6:72907749 G/T cg18830697 chr6:72922368 RIMS1 -0.44 -6.25 -0.36 1.61e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs3008870 0.958 rs12131222 chr1:67438535 A/T cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.19 -0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs8180040 0.764 rs4682852 chr3:47177772 C/T cg27129171 chr3:47204927 SETD2 0.73 11.42 0.57 7.7e-25 Colorectal cancer; CESC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg06481639 chr22:41940642 POLR3H 0.6 5.92 0.34 9.88e-9 Vitiligo; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09060316 chr2:26467451 HADHB;HADHA 0.48 6.16 0.35 2.75e-9 Gut microbiota (bacterial taxa); CESC cis rs9583531 0.550 rs7985098 chr13:111386416 G/A cg24331049 chr13:111365604 ING1 0.73 11.02 0.56 1.66e-23 Coronary artery disease; CESC cis rs7666738 0.830 rs62318470 chr4:98925846 A/C cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs12912251 0.591 rs3104150 chr15:39003585 T/C cg10631289 chr15:39006617 NA -0.48 -5.28 -0.31 2.66e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg04309212 chr2:223183932 NA 0.5 6.66 0.38 1.58e-10 Obesity-related traits; CESC cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg26408565 chr15:76604113 ETFA -0.41 -5.97 -0.34 7.59e-9 Blood metabolite levels; CESC cis rs2832077 0.506 rs2832088 chr21:30158620 G/A cg24692254 chr21:30365293 RNF160 -0.5 -6.04 -0.35 5.21e-9 Cognitive test performance; CESC cis rs9308731 0.644 rs10189015 chr2:111918472 G/A cg04202892 chr2:111875749 ACOXL 0.44 6.33 0.36 1.04e-9 Chronic lymphocytic leukemia; CESC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.55 -6.58 -0.37 2.52e-10 Total body bone mineral density; CESC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg07701084 chr6:150067640 NUP43 0.44 5.95 0.34 8.59e-9 Lung cancer; CESC cis rs684232 0.602 rs34167561 chr17:509268 G/A cg15660573 chr17:549704 VPS53 -0.82 -12.01 -0.59 8.07e-27 Prostate cancer; CESC cis rs11229555 0.645 rs1986404 chr11:58194614 T/C cg15696309 chr11:58395628 NA -0.42 -5.05 -0.3 8.13e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC trans rs561341 1.000 rs8077092 chr17:30281992 T/C cg20587970 chr11:113659929 NA -1.12 -14.05 -0.65 6.66e-34 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13898051 chr5:916145 TRIP13 -0.64 -7.37 -0.41 2.21e-12 Gut microbiome composition (summer); CESC cis rs12477438 0.520 rs2632283 chr2:99776000 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.62 0.61 6.6e-29 Chronic sinus infection; CESC cis rs6546537 1.000 rs6712370 chr2:69855094 C/G cg10773587 chr2:69614142 GFPT1 0.5 6.22 0.36 1.89e-9 Serum thyroid-stimulating hormone levels; CESC cis rs56104184 0.723 rs73063522 chr19:49408358 C/G cg21252483 chr19:49399788 TULP2 -0.49 -5.56 -0.32 6.67e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs9325144 0.647 rs10875953 chr12:39050536 G/C cg26384229 chr12:38710491 ALG10B -0.52 -7.29 -0.41 3.56e-12 Morning vs. evening chronotype; CESC cis rs6964587 0.692 rs12536220 chr7:91805595 T/G cg17063962 chr7:91808500 NA 0.44 6.38 0.36 7.97e-10 Breast cancer; CESC cis rs2455799 0.613 rs4684259 chr3:15791279 G/A cg16303742 chr3:15540471 COLQ -0.39 -6.14 -0.35 3.01e-9 Mean platelet volume; CESC cis rs11031096 0.782 rs2284450 chr11:4149214 A/T cg18678763 chr11:4115507 RRM1 -0.45 -6.24 -0.36 1.69e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs12142240 0.659 rs1984491 chr1:46858607 T/G cg00530320 chr1:46809349 NSUN4 0.6 8.27 0.45 6.54e-15 Menopause (age at onset); CESC cis rs916888 0.773 rs1378358 chr17:44787312 C/T cg17911788 chr17:44343683 NA -0.63 -8.1 -0.45 2.09e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9318086 0.935 rs2025701 chr13:24440581 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.4 5.57 0.32 6.39e-8 Myopia (pathological); CESC cis rs116095464 0.619 rs2303741 chr5:218356 T/C cg22857025 chr5:266934 NA -1.27 -18.89 -0.76 5.51e-51 Breast cancer; CESC cis rs6933660 0.800 rs3800273 chr6:151759035 G/C cg02564969 chr6:151773285 C6orf211;RMND1 0.62 8.57 0.47 8.91e-16 Menarche (age at onset); CESC cis rs1008375 0.931 rs6449328 chr4:17700474 C/T cg02297831 chr4:17616191 MED28 0.48 5.76 0.33 2.36e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg22800045 chr5:56110881 MAP3K1 0.85 10.2 0.53 7.88e-21 Initial pursuit acceleration; CESC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg23758822 chr17:41437982 NA 1.03 15.5 0.69 5.3e-39 Menopause (age at onset); CESC cis rs7917772 0.503 rs11191347 chr10:104351617 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.19 0.3 4.14e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.73 -10.41 -0.54 1.69e-21 Systemic lupus erythematosus; CESC cis rs72802342 0.510 rs12932952 chr16:75365486 C/T cg04384234 chr16:75411784 CFDP1 -0.46 -5.48 -0.32 1.01e-7 Advanced age-related macular degeneration; CESC cis rs9640161 0.711 rs3735170 chr7:150034184 T/C cg21361702 chr7:150065534 REPIN1 0.53 5.74 0.33 2.53e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs75804782 0.521 rs72993073 chr2:239412925 G/A cg18131467 chr2:239335373 ASB1 -0.73 -5.36 -0.31 1.81e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs10754283 0.967 rs1320563 chr1:90121032 G/A cg21401794 chr1:90099060 LRRC8C 0.67 8.84 0.48 1.36e-16 Amyotrophic lateral sclerosis (sporadic); CESC cis rs1790761 0.505 rs7941648 chr11:67347595 C/T cg00290607 chr11:67383545 NA -0.36 -5.33 -0.31 2.14e-7 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14546712 chr8:41478669 AGPAT6 -0.63 -6.87 -0.39 4.66e-11 Gut microbiome composition (summer); CESC cis rs10845606 1.000 rs10845607 chr12:12835228 C/T cg04607235 chr12:12878440 APOLD1 -0.73 -8.21 -0.45 9.75e-15 Systemic lupus erythematosus; CESC cis rs9309473 0.528 rs10191517 chr2:73558403 G/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.66 -0.38 1.55e-10 Metabolite levels; CESC cis rs7772486 0.840 rs2474355 chr6:146312540 C/G cg05347473 chr6:146136440 FBXO30 0.56 7.25 0.41 4.63e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg08027265 chr7:2291960 NA -0.41 -6.23 -0.36 1.78e-9 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.791 rs28579101 chr4:98843203 T/C cg17366294 chr4:99064904 C4orf37 0.52 7.13 0.4 9.5e-12 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg04414720 chr1:150670196 GOLPH3L 0.62 8.92 0.48 8.04e-17 Tonsillectomy; CESC cis rs6088580 0.634 rs6059860 chr20:33063830 A/C cg08999081 chr20:33150536 PIGU 0.66 11.55 0.58 2.83e-25 Glomerular filtration rate (creatinine); CESC cis rs910316 0.726 rs12882664 chr14:75446778 C/T cg16144293 chr14:75469539 EIF2B2 -0.41 -5.25 -0.31 3.05e-7 Height; CESC cis rs76419734 0.558 rs7696836 chr4:106583826 C/T cg24545054 chr4:106630052 GSTCD;INTS12 0.73 9.65 0.51 4.57e-19 Post bronchodilator FEV1; CESC cis rs6541297 0.699 rs4846915 chr1:230296470 C/A cg20703242 chr1:230279135 GALNT2 0.61 6.92 0.39 3.31e-11 Coronary artery disease; CESC trans rs7089973 0.523 rs7093330 chr10:116744574 T/A cg17463145 chr7:79084011 MAGI2 0.32 6.36 0.36 8.92e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06059318 chr7:72936700 BAZ1B -0.46 -6.61 -0.38 2.14e-10 Gambling; CESC cis rs7577696 0.597 rs212751 chr2:32418808 T/A cg02381751 chr2:32503542 YIPF4 0.45 5.41 0.32 1.4e-7 Inflammatory biomarkers; CESC cis rs61935443 0.778 rs78522691 chr12:95267340 G/T cg21533806 chr12:95267307 NA 0.56 6.87 0.39 4.56e-11 Schizophrenia; CESC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.89e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg12756686 chr19:29218302 NA 0.58 7.52 0.42 8.38e-13 Methadone dose in opioid dependence; CESC cis rs12220238 0.908 rs10824086 chr10:75912668 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.65 6.18 0.36 2.35e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2777491 0.874 rs1655556 chr15:41777935 A/C cg20272979 chr15:41787780 ITPKA 0.42 6.19 0.36 2.29e-9 Ulcerative colitis; CESC cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg05347473 chr6:146136440 FBXO30 0.58 7.33 0.41 2.84e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs5758659 0.652 rs133305 chr22:42395960 C/T cg15557168 chr22:42548783 NA -0.43 -6.34 -0.36 9.99e-10 Cognitive function; CESC cis rs8077577 0.731 rs11869952 chr17:18221713 T/C cg16794390 chr17:18148240 FLII 0.4 6.34 0.36 9.98e-10 Obesity-related traits; CESC cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg05347473 chr6:146136440 FBXO30 0.57 7.24 0.41 4.72e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg00166722 chr3:10149974 C3orf24 -0.51 -6.7 -0.38 1.26e-10 Alzheimer's disease; CESC cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg23711669 chr6:146136114 FBXO30 -0.99 -14.35 -0.66 5.95e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs72781680 0.950 rs72798404 chr2:24180125 C/T cg08917208 chr2:24149416 ATAD2B 1.12 10.07 0.53 2.16e-20 Lymphocyte counts; CESC cis rs13385 0.769 rs67836595 chr5:139603615 G/A cg26211634 chr5:139558579 C5orf32 0.49 5.39 0.31 1.58e-7 Atrial fibrillation; CESC cis rs6540559 0.673 rs17317411 chr1:209961314 C/T cg25204440 chr1:209979598 IRF6 -0.61 -5.84 -0.34 1.53e-8 Cleft lip with or without cleft palate; CESC cis rs2294693 0.730 rs9369248 chr6:40959664 G/T cg14769373 chr6:40998127 UNC5CL 0.41 5.16 0.3 4.87e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs7107174 1.000 rs2511156 chr11:77971167 G/C cg02023728 chr11:77925099 USP35 0.48 6.34 0.36 9.87e-10 Testicular germ cell tumor; CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg22907277 chr7:1156413 C7orf50 0.45 6.55 0.37 2.97e-10 Longevity;Endometriosis; CESC cis rs9467711 0.659 rs13216828 chr6:26373507 G/A cg12826209 chr6:26865740 GUSBL1 0.62 5.34 0.31 1.96e-7 Autism spectrum disorder or schizophrenia; CESC trans rs709082 0.742 rs709098 chr3:191469920 A/C cg25305879 chr2:106814630 NA 0.4 6.63 0.38 1.89e-10 Colonoscopy-negative controls vs population controls; CESC cis rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01035013 chr16:56458628 AMFR -0.41 -5.72 -0.33 2.89e-8 Gambling; CESC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg01238044 chr22:24384105 GSTT1 -0.52 -6.6 -0.38 2.26e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg09658497 chr7:2847517 GNA12 -0.43 -6.09 -0.35 4.01e-9 Height; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg26084319 chr14:21905280 CHD8 -0.55 -6.14 -0.35 2.94e-9 Subjective well-being; CESC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg06484146 chr7:12443880 VWDE -0.75 -10.31 -0.54 3.55e-21 Coronary artery disease; CESC cis rs17095355 1.000 rs734164 chr10:111698160 C/T cg00817464 chr10:111662876 XPNPEP1 -0.43 -5.2 -0.3 4.01e-7 Biliary atresia; CESC cis rs1881797 0.932 rs4551631 chr1:247667663 C/T cg21399703 chr1:247681439 NA -0.65 -8.75 -0.47 2.54e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.73 8.83 0.48 1.43e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg04034577 chr2:241836375 C2orf54 -0.49 -8.75 -0.47 2.51e-16 Urinary metabolites; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07007882 chr1:2517512 C1orf93 -0.52 -6.03 -0.35 5.56e-9 Gut microbiome composition (summer); CESC cis rs3026101 0.671 rs12602061 chr17:5302645 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs3126085 0.935 rs1390487 chr1:152194601 G/A cg03465714 chr1:152285911 FLG -0.43 -5.19 -0.3 4.12e-7 Atopic dermatitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17917959 chr17:79197229 AZI1 0.56 6.19 0.36 2.33e-9 Gut microbiome composition (summer); CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg16265552 chr3:113667068 ZDHHC23 0.47 6.31 0.36 1.19e-9 Weight; CESC cis rs67460515 0.892 rs4856703 chr3:161047720 G/T cg03342759 chr3:160939853 NMD3 -0.54 -7.73 -0.43 2.27e-13 Parkinson's disease; CESC cis rs11191419 1 rs11191419 chr10:104612335 T/A cg15744005 chr10:104629667 AS3MT -0.37 -5.49 -0.32 9.33e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 12.86 0.62 9.59e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg07507251 chr3:52567010 NT5DC2 0.43 7.43 0.41 1.54e-12 Bipolar disorder; CESC cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.18 0.3 4.37e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11871801 0.915 rs647397 chr17:40679398 G/A cg14558262 chr17:40713999 COASY 0.47 5.15 0.3 5.2e-7 Crohn's disease; CESC cis rs72627123 0.867 rs73301479 chr14:74467757 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.79 5.74 0.33 2.6e-8 Morning vs. evening chronotype; CESC cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg26597838 chr10:835615 NA 0.79 9.46 0.5 1.69e-18 Eosinophil percentage of granulocytes; CESC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg08564027 chr20:61660810 NA 0.9 15.31 0.69 2.47e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg19717773 chr7:2847554 GNA12 -0.56 -8.02 -0.44 3.48e-14 Height; CESC cis rs3733585 0.699 rs4515163 chr4:9959603 C/T cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs61931739 0.500 rs10772154 chr12:34373271 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.46 0.42 1.25e-12 Morning vs. evening chronotype; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03016991 chr12:109124380 CORO1C -0.44 -6.08 -0.35 4.1e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4253772 0.637 rs9627402 chr22:46702586 C/T cg09491104 chr22:46646882 C22orf40 -0.54 -6.29 -0.36 1.28e-9 LDL cholesterol;Cholesterol, total; CESC cis rs2732480 0.500 rs1387257 chr12:48636666 C/A cg04545296 chr12:48745243 ZNF641 0.39 6.47 0.37 4.62e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2243480 1.000 rs6460260 chr7:65215455 T/C cg25894440 chr7:65020034 NA 0.65 5.42 0.32 1.36e-7 Diabetic kidney disease; CESC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg13206674 chr6:150067644 NUP43 0.43 6.13 0.35 3.26e-9 Lung cancer; CESC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg08888203 chr3:10149979 C3orf24 0.46 6.03 0.35 5.45e-9 Alzheimer's disease; CESC cis rs7772486 0.846 rs2492856 chr6:146323928 A/G cg23711669 chr6:146136114 FBXO30 0.76 10.57 0.54 5.07e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg17724175 chr1:150552817 MCL1 0.41 6.29 0.36 1.27e-9 Melanoma; CESC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.69 -0.33 3.38e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs977987 0.671 rs9922008 chr16:75335406 T/C cg03315344 chr16:75512273 CHST6 0.41 5.36 0.31 1.78e-7 Dupuytren's disease; CESC cis rs1185460 0.967 rs4454730 chr11:118937444 G/A cg23280166 chr11:118938394 VPS11 0.57 8.01 0.44 3.63e-14 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13625205 chr1:151584902 SNX27 -0.47 -6.39 -0.37 7.59e-10 Ulcerative colitis; CESC cis rs7949030 0.653 rs2849030 chr11:62366986 G/A cg02375832 chr11:62437615 C11orf48 0.36 5.16 0.3 4.92e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg26769984 chr7:1090371 C7orf50 0.54 6.34 0.36 9.95e-10 Bronchopulmonary dysplasia; CESC cis rs2625529 0.730 rs12912771 chr15:72162928 A/T cg16672083 chr15:72433130 SENP8 -0.39 -5.99 -0.35 6.93e-9 Red blood cell count; CESC cis rs7267979 0.903 rs6115118 chr20:25246734 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.08 0.68 1.65e-37 Liver enzyme levels (alkaline phosphatase); CESC cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg20503657 chr10:835505 NA 1.09 9.8 0.52 1.52e-19 Eosinophil percentage of granulocytes; CESC cis rs7786808 0.712 rs12671981 chr7:158202971 G/A cg09998033 chr7:158218633 PTPRN2 -0.4 -5.72 -0.33 2.82e-8 Obesity-related traits; CESC cis rs12249377 0.519 rs4520504 chr10:92602373 T/C cg14313238 chr10:92632228 RPP30 0.44 5.51 0.32 8.63e-8 White matter microstructure (global fractional anisotropy); CESC cis rs9435341 0.965 rs6669831 chr1:107608607 G/A cg09367891 chr1:107599246 PRMT6 -0.56 -7.07 -0.4 1.38e-11 Facial morphology (factor 21, depth of nasal alae); CESC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -7.03 -0.4 1.77e-11 Bipolar disorder and schizophrenia; CESC cis rs15676 0.783 rs10988119 chr9:131564585 T/C cg00228799 chr9:131580591 ENDOG -0.49 -6.09 -0.35 3.93e-9 Blood metabolite levels; CESC cis rs2742417 1.000 rs2742423 chr3:45733430 A/G cg10512202 chr3:45649293 LIMD1 0.36 5.16 0.3 4.87e-7 Response to anti-depressant treatment in major depressive disorder; CESC cis rs7259376 0.936 rs2195965 chr19:22538111 C/T cg02657401 chr19:22469223 NA -0.25 -5.07 -0.3 7.33e-7 Menopause (age at onset); CESC cis rs11190604 1.000 rs11190551 chr10:102204734 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs1545257 0.537 rs11125583 chr2:24646278 C/A cg06627628 chr2:24431161 ITSN2 -0.49 -5.87 -0.34 1.3e-8 Sjögren's syndrome; CESC cis rs5769765 0.955 rs7511159 chr22:50307896 A/G cg26441486 chr22:50317300 CRELD2 0.39 5.19 0.3 4.11e-7 Schizophrenia; CESC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg26354017 chr1:205819088 PM20D1 -0.82 -13.11 -0.63 1.33e-30 Menarche (age at onset); CESC cis rs116095464 0.558 rs3213838 chr5:223890 G/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.65 0.33 4.24e-8 Breast cancer; CESC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg18479299 chr3:125709523 NA -0.48 -5.06 -0.3 7.98e-7 Blood pressure (smoking interaction); CESC trans rs875971 1.000 rs4718343 chr7:65874288 T/G cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.77e-9 Aortic root size; CESC cis rs854765 0.547 rs9897761 chr17:17912011 A/T cg04398451 chr17:18023971 MYO15A -0.69 -10.33 -0.54 3.02e-21 Total body bone mineral density; CESC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg24818145 chr4:99064322 C4orf37 0.39 5.06 0.3 7.72e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6694270 0.529 rs35941610 chr1:19104930 C/T cg19637330 chr1:19110922 NA -0.49 -6.04 -0.35 5.13e-9 Drug-induced liver injury (nitrofurantoin); CESC cis rs2228479 0.850 rs2238525 chr16:89809902 T/C cg27121462 chr16:89883253 FANCA 0.65 5.31 0.31 2.35e-7 Skin colour saturation; CESC cis rs8062405 0.755 rs2077031 chr16:28603168 T/A cg01378222 chr16:28622494 SULT1A1 0.31 5.16 0.3 4.92e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4803468 1.000 rs11880539 chr19:41918949 A/C cg14132834 chr19:41945861 ATP5SL 0.59 7.37 0.41 2.2e-12 Height; CESC cis rs1143633 0.566 rs12987491 chr2:113691499 G/A cg12858261 chr2:113808755 IL1F8 -0.44 -5.38 -0.31 1.63e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs11166629 1.000 rs2873014 chr8:135645860 C/T cg27224718 chr8:135614730 ZFAT -0.49 -6.17 -0.35 2.58e-9 Smoking quantity; CESC cis rs642858 0.543 rs1933743 chr6:140291158 T/C cg27524944 chr6:140295369 NA -0.32 -5.59 -0.32 5.74e-8 Type 2 diabetes; CESC cis rs6460942 0.597 rs17277369 chr7:12536192 A/G cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs1707322 0.721 rs9793568 chr1:46130373 G/A cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs13191362 0.507 rs1954810 chr6:163061749 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.51 -6.06 -0.35 4.65e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4253772 0.591 rs6007727 chr22:46650959 G/A cg24881330 chr22:46731750 TRMU 0.89 10.09 0.53 1.86e-20 LDL cholesterol;Cholesterol, total; CESC cis rs4635554 0.640 rs12997242 chr2:21381177 G/A cg00673290 chr2:21266727 APOB 0.32 5.07 0.3 7.3e-7 Hypertriglyceridemia; CESC cis rs17384381 1.000 rs17388521 chr1:85897904 A/G cg16011679 chr1:85725395 C1orf52 -0.75 -7.68 -0.43 3.17e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg26338869 chr17:61819248 STRADA 0.69 9.02 0.48 3.77e-17 Prudent dietary pattern; CESC cis rs9467711 0.606 rs9393705 chr6:26361011 G/A cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.52e-7 Autism spectrum disorder or schizophrenia; CESC cis rs35955747 0.934 rs131200 chr22:31703272 T/C cg25791279 chr22:32026902 PISD 0.49 5.88 0.34 1.25e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg06456125 chr7:65229604 NA -0.44 -5.65 -0.33 4.22e-8 Aortic root size; CESC cis rs3008870 1.000 rs2755256 chr1:67471692 A/T cg02640540 chr1:67518911 SLC35D1 0.51 5.43 0.32 1.25e-7 Lymphocyte percentage of white cells; CESC cis rs6032067 0.929 rs6017512 chr20:43835038 G/A cg10761708 chr20:43804764 PI3 0.5 5.91 0.34 1.02e-8 Blood protein levels; CESC cis rs1832871 0.630 rs11754501 chr6:158710451 A/G cg07165851 chr6:158734300 TULP4 0.56 6.34 0.36 9.74e-10 Height; CESC cis rs4595586 0.545 rs12831116 chr12:39401456 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.67 0.33 3.75e-8 Morning vs. evening chronotype; CESC cis rs1801251 0.929 rs12694917 chr2:233707611 C/T cg25237894 chr2:233734115 C2orf82 -0.46 -8.11 -0.45 1.84e-14 Coronary artery disease; CESC cis rs7904368 0.754 rs7076779 chr10:16852667 C/T cg23933602 chr10:16859644 RSU1 0.65 6.33 0.36 1.02e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs9287719 0.810 rs7601748 chr2:10785446 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.64 -0.33 4.27e-8 Prostate cancer; CESC cis rs8014204 0.839 rs6574197 chr14:75331487 A/G cg11812906 chr14:75593930 NEK9 -0.41 -5.06 -0.3 7.77e-7 Caffeine consumption; CESC trans rs931812 0.964 rs2102290 chr8:101919844 G/C cg20993868 chr7:22813445 NA 0.46 6.55 0.37 3.03e-10 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs6665290 0.582 rs72764213 chr1:227207391 C/T cg10327440 chr1:227177885 CDC42BPA -1.16 -25.65 -0.84 9.23e-74 Myeloid white cell count; CESC cis rs9911578 1.000 rs12938772 chr17:56776320 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.01 -0.4 1.97e-11 Intelligence (multi-trait analysis); CESC cis rs8067545 0.559 rs3874846 chr17:20297545 T/G cg13482628 chr17:19912719 NA 0.39 5.1 0.3 6.6e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26593380 chr7:4749206 FOXK1 -0.69 -8.02 -0.44 3.39e-14 Gut microbiome composition (summer); CESC cis rs2354432 1.000 rs11239944 chr1:146691015 C/T cg25205988 chr1:146714368 CHD1L 0.84 10.61 0.55 3.88e-22 Mitochondrial DNA levels; CESC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg06601766 chr17:61851465 DDX42;CCDC47 -0.79 -10.52 -0.54 7.28e-22 Height; CESC cis rs6142102 0.625 rs4911381 chr20:32550345 C/G cg08999081 chr20:33150536 PIGU -0.33 -5.09 -0.3 6.91e-7 Skin pigmentation; CESC cis rs6964587 0.839 rs13246743 chr7:91453945 G/T cg17063962 chr7:91808500 NA 0.5 6.39 0.37 7.42e-10 Breast cancer; CESC cis rs4955124 0.558 rs62244393 chr3:32020533 T/G cg05935571 chr3:32023257 ZNF860;OSBPL10 0.96 8.7 0.47 3.56e-16 Schizophrenia; CESC cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 6.44 0.37 5.47e-10 Mean platelet volume; CESC cis rs933688 1.000 rs12654787 chr5:90713259 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 14.23 0.66 1.63e-34 Smoking behavior; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18050295 chr3:12949921 IQSEC1 -0.61 -6.6 -0.38 2.19e-10 Gut microbiome composition (summer); CESC cis rs16854884 0.837 rs6767236 chr3:143758399 A/C cg06585982 chr3:143692056 C3orf58 0.48 5.74 0.33 2.57e-8 Economic and political preferences (feminism/equality); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05075692 chr10:11321989 CUGBP2 0.43 6.17 0.35 2.58e-9 Fibrinogen levels; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg19603075 chr15:89010536 MRPS11;MRPL46 -0.54 -6.37 -0.36 8.23e-10 Gut microbiota (bacterial taxa); CESC cis rs2985684 0.894 rs2281837 chr14:50065359 C/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.44 -5.36 -0.31 1.84e-7 Carotid intima media thickness; CESC trans rs2727020 0.796 rs7131672 chr11:49274421 A/C cg03929089 chr4:120376271 NA 0.7 8.57 0.47 8.49e-16 Coronary artery disease; CESC trans rs9929218 0.508 rs1559366 chr16:68799611 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.87 14.08 0.65 5.39e-34 Colorectal cancer; CESC cis rs703842 0.585 rs10877022 chr12:58223937 A/G cg00677455 chr12:58241039 CTDSP2 0.78 10.61 0.55 3.74e-22 Multiple sclerosis; CESC cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24544309 chr1:27096392 ARID1A -0.49 -6.01 -0.35 6.25e-9 Gut microbiome composition (summer); CESC trans rs7246760 0.881 rs68018725 chr19:9855919 C/T cg02900749 chr2:68251473 NA -0.77 -7.15 -0.4 8.22e-12 Pursuit maintenance gain; CESC cis rs10832963 1.000 rs10832956 chr11:18645668 A/G cg20219074 chr11:18656078 SPTY2D1 0.81 12.1 0.6 3.92e-27 Breast cancer; CESC cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.26 0.31 3.03e-7 Colonoscopy-negative controls vs population controls; CESC trans rs801193 0.904 rs4718403 chr7:66242729 C/G cg26939375 chr7:64535504 NA 0.66 9.12 0.49 1.89e-17 Aortic root size; CESC cis rs2425143 1.000 rs4602287 chr20:34368028 C/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.72 -6.67 -0.38 1.52e-10 Blood protein levels; CESC cis rs9640161 0.742 rs11983355 chr7:150016697 A/C cg10018233 chr7:150070692 REPIN1 0.47 7.29 0.41 3.54e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs3096299 0.900 rs2911258 chr16:89480760 A/G cg02034447 chr16:89574710 SPG7 0.42 5.29 0.31 2.54e-7 Multiple myeloma (IgH translocation); CESC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.71 6.1 0.35 3.74e-9 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14591195 chr17:7382608 ZBTB4 -0.59 -6.3 -0.36 1.27e-9 Gut microbiome composition (summer); CESC cis rs2013441 0.670 rs12937327 chr17:19978984 C/T cg12073167 chr17:19770448 ULK2 -0.43 -5.21 -0.3 3.88e-7 Obesity-related traits; CESC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.52 -0.37 3.57e-10 Bipolar disorder; CESC cis rs992157 0.698 rs6746089 chr2:219170377 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.64 8.53 0.46 1.17e-15 Colorectal cancer; CESC cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.47 7.94 0.44 5.76e-14 Monocyte percentage of white cells; CESC trans rs2213920 0.573 rs10982772 chr9:118277948 T/G cg19746719 chr20:55904677 SPO11 0.47 6.14 0.35 3.01e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CESC cis rs10463316 0.894 rs7708499 chr5:150765906 A/C cg03212797 chr5:150827313 SLC36A1 -0.46 -6.04 -0.35 5.23e-9 Metabolite levels (Pyroglutamine); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03550773 chr14:35163458 NA -0.46 -6.28 -0.36 1.39e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg01475377 chr6:109611718 NA -0.51 -8.27 -0.45 6.49e-15 Reticulocyte fraction of red cells; CESC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg20243544 chr17:37824526 PNMT -0.47 -5.94 -0.34 9.04e-9 Glomerular filtration rate (creatinine); CESC cis rs7631605 0.819 rs4678922 chr3:37022864 A/T cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.08 -0.3 7.06e-7 Cerebrospinal P-tau181p levels; CESC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.73 -10.27 -0.53 4.75e-21 Prudent dietary pattern; CESC cis rs11642862 0.710 rs17849880 chr16:30999198 C/T cg02466173 chr16:30829666 NA -0.57 -5.21 -0.3 3.81e-7 Tonsillectomy; CESC cis rs3820928 0.874 rs1917127 chr2:227895125 A/G cg11843606 chr2:227700838 RHBDD1 -0.48 -6.38 -0.36 8.04e-10 Pulmonary function; CESC cis rs7923609 0.967 rs10761751 chr10:65154885 A/G cg01631684 chr10:65280961 REEP3 -0.42 -5.32 -0.31 2.21e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.99e-8 Eye color traits; CESC cis rs7044106 0.791 rs10739572 chr9:123489815 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.61 0.33 4.98e-8 Hip circumference adjusted for BMI; CESC cis rs3760982 0.585 rs67704568 chr19:44294019 T/C cg11993925 chr19:44307056 LYPD5 0.34 5.73 0.33 2.66e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg10667709 chr2:218712772 TNS1 -0.46 -6.35 -0.36 9.22e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs1062177 0.855 rs62395861 chr5:151269270 A/G cg12924095 chr5:151150029 G3BP1 0.43 5.35 0.31 1.93e-7 Preschool internalizing problems; CESC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg08968635 chr6:28129556 ZNF389 0.36 5.09 0.3 6.94e-7 Parkinson's disease; CESC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC trans rs57221529 0.766 rs12521988 chr5:556421 C/T cg25482853 chr8:67687455 SGK3 1.11 11.94 0.59 1.39e-26 Lung disease severity in cystic fibrosis; CESC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg06028808 chr11:68637592 NA 0.43 5.12 0.3 5.87e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2288073 0.965 rs10185445 chr2:24410976 A/C cg06627628 chr2:24431161 ITSN2 0.71 8.38 0.46 3.04e-15 Venous thromboembolism (SNP x SNP interaction); CESC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.07e-8 Lung cancer; CESC cis rs1707322 1.000 rs12060274 chr1:46291062 G/T cg05343316 chr1:45956843 TESK2 0.41 5.05 0.3 8.05e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6088580 0.524 rs6088564 chr20:33249444 A/G cg24642439 chr20:33292090 TP53INP2 -0.47 -5.53 -0.32 7.81e-8 Glomerular filtration rate (creatinine); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12168153 chr19:55770892 SAPS1 0.44 6.04 0.35 5.1e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7659604 0.540 rs13140070 chr4:122713899 C/T cg19671926 chr4:122722719 EXOSC9 0.67 8.87 0.48 1.12e-16 Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12251659 chr12:122018385 KDM2B -0.46 -6.13 -0.35 3.21e-9 Fibrinogen levels; CESC cis rs3740713 1.000 rs61081934 chr11:18454317 G/A cg23797887 chr11:18477753 LDHAL6A -0.53 -5.11 -0.3 6.1e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs4535700 0.501 rs60517461 chr7:56017645 G/T cg09872392 chr7:56161020 PHKG1 0.41 5.85 0.34 1.43e-8 Macular telangiectasia type 2; CESC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg25036284 chr2:26402008 FAM59B 0.86 9.4 0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.1 -12.68 -0.61 4e-29 Gut microbiome composition (summer); CESC trans rs61931739 0.534 rs12372557 chr12:34363843 C/T cg26384229 chr12:38710491 ALG10B 0.68 10.06 0.53 2.22e-20 Morning vs. evening chronotype; CESC cis rs854765 0.616 rs8070624 chr17:17843396 G/A cg16928487 chr17:17741425 SREBF1 -0.56 -9.22 -0.49 9.83e-18 Total body bone mineral density; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg08679808 chr17:79886116 LOC92659;MAFG -0.49 -6.23 -0.36 1.85e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs9929218 0.953 rs28608872 chr16:68802038 A/G cg02972257 chr16:68554789 NA 0.43 5.22 0.31 3.65e-7 Colorectal cancer; CESC cis rs11585357 0.895 rs877552 chr1:17631236 C/T cg08277548 chr1:17600880 PADI3 -0.55 -5.34 -0.31 2.02e-7 Hair shape; CESC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg05896524 chr21:47604654 C21orf56 0.4 5.26 0.31 2.95e-7 Testicular germ cell tumor; CESC trans rs634534 0.591 rs688862 chr11:65733393 A/G cg17712092 chr4:129076599 LARP1B 0.59 7.59 0.42 5.38e-13 Sum eosinophil basophil counts;Eosinophil counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05899727 chr19:17970713 RPL18AP3;RPL18A -0.63 -7.14 -0.4 9.2e-12 Gut microbiome composition (summer); CESC cis rs11587400 0.572 rs2268697 chr1:115227493 A/G cg12756093 chr1:115239321 AMPD1 0.51 7.18 0.4 7.15e-12 Autism; CESC cis rs2777491 1.000 rs1757455 chr15:41761332 G/T cg20272979 chr15:41787780 ITPKA 0.44 6.5 0.37 4.02e-10 Ulcerative colitis; CESC cis rs1707322 1.000 rs6682683 chr1:46342337 A/G cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs863345 0.604 rs2054991 chr1:158506083 A/G cg12129480 chr1:158549410 OR10X1 0.33 6.82 0.39 6.24e-11 Pneumococcal bacteremia; CESC cis rs2295499 0.643 rs3733215 chr4:2698364 C/T cg27239842 chr4:2403781 ZFYVE28 -0.33 -5.58 -0.32 5.88e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs36051895 0.632 rs12352022 chr9:5161836 T/G cg02405213 chr9:5042618 JAK2 -0.54 -6.46 -0.37 4.86e-10 Pediatric autoimmune diseases; CESC cis rs7527798 0.592 rs12411037 chr1:207857158 T/C cg21110645 chr1:207815933 NA -0.3 -5.16 -0.3 4.79e-7 Erythrocyte sedimentation rate; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12909921 chr17:37558512 FBXL20 0.5 6.49 0.37 4.12e-10 Gut microbiota (bacterial taxa); CESC cis rs78707713 0.841 rs76628955 chr10:71208625 C/T cg12610070 chr10:71211762 TSPAN15 -0.36 -6.48 -0.37 4.36e-10 Venous thromboembolism; CESC trans rs11098499 0.542 rs10440343 chr4:120309787 G/C cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs11098499 0.954 rs9993199 chr4:120392873 A/G cg24375607 chr4:120327624 NA -0.43 -5.4 -0.31 1.49e-7 Corneal astigmatism; CESC cis rs6502050 0.761 rs12150321 chr17:80061558 T/C cg23985595 chr17:80112537 CCDC57 0.41 6.28 0.36 1.38e-9 Life satisfaction; CESC cis rs13095912 1.000 rs36066570 chr3:185314454 C/A cg11274856 chr3:185301563 NA 0.37 6.08 0.35 4.07e-9 Systolic blood pressure; CESC trans rs4906172 0.773 rs941793 chr14:102507461 A/G cg17920195 chr4:129149383 NA 0.32 6.28 0.36 1.37e-9 Menopause (age at onset); CESC cis rs1062177 0.901 rs1549622 chr5:151266049 A/G cg00977110 chr5:151150581 G3BP1 0.67 7.43 0.42 1.46e-12 Preschool internalizing problems; CESC cis rs2522056 1.000 rs2522063 chr5:131805591 G/T cg24060327 chr5:131705240 SLC22A5 0.61 6.93 0.39 3.22e-11 Lymphocyte counts;Fibrinogen; CESC cis rs2109514 0.902 rs717957 chr7:116113107 G/C cg12739419 chr7:116140593 CAV2 -0.38 -6.85 -0.39 5.19e-11 Prevalent atrial fibrillation; CESC trans rs35110281 0.693 rs11089093 chr21:45121161 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 6.2 0.36 2.13e-9 Mean corpuscular volume; CESC cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg14500267 chr11:67383377 NA -0.36 -5.67 -0.33 3.77e-8 Mean corpuscular volume; CESC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg07677032 chr17:61819896 STRADA 0.48 6.53 0.37 3.3e-10 Prudent dietary pattern; CESC trans rs4843747 0.605 rs4072779 chr16:88107290 C/T cg26811252 chr16:29126840 RRN3P2 0.67 9.46 0.5 1.77e-18 Menopause (age at onset); CESC cis rs12681366 0.734 rs13281619 chr8:95396886 A/G cg13257157 chr8:95487014 RAD54B 0.38 5.14 0.3 5.22e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs9916302 0.821 rs12938268 chr17:37572139 G/A cg07936489 chr17:37558343 FBXL20 -0.78 -10.65 -0.55 2.75e-22 Glomerular filtration rate (creatinine); CESC cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6740322 0.895 rs6738717 chr2:43573670 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -7.33 -0.41 2.79e-12 Coronary artery disease; CESC cis rs3925075 0.966 rs11645917 chr16:31359826 C/T cg02846316 chr16:31340340 ITGAM 0.42 6.6 0.38 2.24e-10 IgA nephropathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13531596 chr19:39894559 NA 0.52 6.0 0.35 6.45e-9 Gut microbiome composition (summer); CESC cis rs56104184 0.723 rs73063524 chr19:49409004 T/C cg21252483 chr19:49399788 TULP2 -0.49 -5.56 -0.32 6.67e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03591709 chr4:110481296 CCDC109B -0.55 -7.4 -0.41 1.82e-12 Fibrinogen levels; CESC cis rs8005677 1.000 rs8006409 chr14:23396511 A/G cg25600027 chr14:23388339 RBM23 -0.43 -5.27 -0.31 2.85e-7 Cognitive ability (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21047938 chr2:10192422 KLF11 -0.55 -6.04 -0.35 5.07e-9 Gut microbiome composition (summer); CESC cis rs7937682 0.889 rs1784786 chr11:111486043 A/G cg09085632 chr11:111637200 PPP2R1B 0.93 13.96 0.65 1.41e-33 Primary sclerosing cholangitis; CESC cis rs17376456 0.877 rs34184666 chr5:93444584 T/C cg25358565 chr5:93447407 FAM172A 1.15 11.35 0.57 1.34e-24 Diabetic retinopathy; CESC cis rs6662572 1.000 rs72688460 chr1:46111094 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 5.65 0.33 4.09e-8 Blood protein levels; CESC cis rs782590 0.607 rs2061032 chr2:55679490 T/C cg18811423 chr2:55921094 PNPT1 0.46 6.35 0.36 9.5e-10 Metabolic syndrome; CESC cis rs10489525 0.599 rs34710929 chr1:115606608 G/A cg12756093 chr1:115239321 AMPD1 -0.45 -5.54 -0.32 7.32e-8 Autism; CESC cis rs6582630 0.519 rs11181526 chr12:38360230 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.77 0.33 2.24e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9287719 0.837 rs4233882 chr2:10755564 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.51 -0.32 8.5e-8 Prostate cancer; CESC cis rs3785574 0.962 rs114027117 chr17:61939935 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.78 10.57 0.54 5.09e-22 Height; CESC cis rs4974559 0.790 rs11933855 chr4:1315183 C/T cg02980000 chr4:1222292 CTBP1 0.61 7.14 0.4 8.92e-12 Systolic blood pressure; CESC cis rs4746818 1.000 rs7916991 chr10:70895373 C/A cg11621586 chr10:70884670 VPS26A 0.83 8.36 0.46 3.65e-15 Left atrial antero-posterior diameter; CESC cis rs6831352 0.918 rs2213035 chr4:100064233 G/A cg12011299 chr4:100065546 ADH4 -0.58 -6.31 -0.36 1.14e-9 Alcohol dependence; CESC cis rs12618769 0.597 rs72819965 chr2:99023719 G/C cg10123293 chr2:99228465 UNC50 0.4 5.23 0.31 3.48e-7 Bipolar disorder; CESC cis rs7208859 0.623 rs12103508 chr17:29086781 T/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10788972 0.787 rs6674720 chr1:54539339 C/G cg25741118 chr1:54482237 LDLRAD1 -0.22 -5.25 -0.31 3.19e-7 Parkinson disease and lewy body pathology; CESC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg14393609 chr7:65229607 NA -0.4 -5.7 -0.33 3.2e-8 Aortic root size; CESC cis rs2749592 0.550 rs12255038 chr10:37869332 T/C cg00409905 chr10:38381863 ZNF37A 0.43 5.63 0.33 4.61e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs16973500 0.732 rs1549292 chr16:71983664 A/C cg09427745 chr16:71932006 KIAA0174 -0.49 -5.19 -0.3 4.28e-7 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.34 -5.45 -0.32 1.17e-7 Cystic fibrosis severity; CESC cis rs7666738 0.830 rs7694889 chr4:98855596 T/C cg17366294 chr4:99064904 C4orf37 0.54 7.48 0.42 1.1e-12 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 0.966 rs2227890 chr20:25260931 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.21e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs9467773 0.620 rs3800303 chr6:26598188 A/G cg11502198 chr6:26597334 ABT1 0.49 7.04 0.4 1.64e-11 Intelligence (multi-trait analysis); CESC cis rs60154123 0.772 rs614167 chr1:210425895 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.5 5.23 0.31 3.37e-7 Coronary artery disease; CESC cis rs561341 0.824 rs1978115 chr17:30220776 A/C cg13647721 chr17:30228624 UTP6 0.59 5.59 0.32 5.55e-8 Hip circumference adjusted for BMI; CESC cis rs2072732 0.861 rs55863899 chr1:2955245 C/G cg15211996 chr1:2936768 ACTRT2 0.36 5.08 0.3 7.07e-7 Plateletcrit; CESC cis rs6540556 0.723 rs12120361 chr1:209913473 A/C cg23920097 chr1:209922102 NA -0.39 -5.22 -0.31 3.7e-7 Red blood cell count; CESC cis rs72781680 0.848 rs715646 chr2:24010566 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs3741151 0.687 rs7933355 chr11:73236817 G/C cg17517138 chr11:73019481 ARHGEF17 0.78 6.37 0.36 8.35e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs6987853 0.966 rs2974338 chr8:42391945 A/G cg09913449 chr8:42400586 C8orf40 0.39 6.13 0.35 3.15e-9 Mean corpuscular hemoglobin concentration; CESC cis rs6982240 0.514 rs7002268 chr8:142277340 A/G cg00131261 chr8:142287264 NA -0.54 -7.39 -0.41 1.93e-12 Tonsillectomy; CESC cis rs7188697 0.743 rs11859781 chr16:58602589 T/A cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC cis rs11098499 0.909 rs11098530 chr4:120413154 C/T cg24375607 chr4:120327624 NA 0.46 5.63 0.33 4.52e-8 Corneal astigmatism; CESC cis rs7818688 0.697 rs35032356 chr8:95977484 G/T cg16049864 chr8:95962084 TP53INP1 0.57 5.73 0.33 2.79e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs4253772 0.872 rs78864133 chr22:46638486 C/T cg00784671 chr22:46762841 CELSR1 -0.5 -5.25 -0.31 3.2e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg22823121 chr1:150693482 HORMAD1 0.36 5.09 0.3 6.86e-7 Melanoma; CESC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg09359103 chr1:154839909 KCNN3 -0.65 -12.33 -0.6 6.58e-28 Prostate cancer; CESC cis rs734999 0.549 rs60733400 chr1:2516781 G/A cg20673091 chr1:2541236 MMEL1 0.42 6.69 0.38 1.36e-10 Ulcerative colitis; CESC cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg05585544 chr11:47624801 NA -0.52 -7.88 -0.44 8.44e-14 Subjective well-being; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12508534 chr6:34855789 TAF11;ANKS1A -0.44 -6.15 -0.35 2.89e-9 Fibrinogen levels; CESC cis rs524023 0.874 rs506338 chr11:64440920 T/C cg07220939 chr11:64358617 SLC22A12 -0.35 -5.41 -0.32 1.41e-7 Urate levels in obese individuals; CESC cis rs6547741 1.000 rs6737921 chr2:27839107 T/C cg21248554 chr2:27665150 KRTCAP3 0.24 5.08 0.3 7.28e-7 Oral cavity cancer; CESC cis rs6964587 0.610 rs6950682 chr7:91464218 G/T cg17063962 chr7:91808500 NA 0.43 5.85 0.34 1.48e-8 Breast cancer; CESC cis rs2249625 0.526 rs17725666 chr6:72889711 G/A cg18830697 chr6:72922368 RIMS1 0.4 5.75 0.33 2.45e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs4834770 1.000 rs10034579 chr4:120244029 A/C cg09307838 chr4:120376055 NA 0.44 5.24 0.31 3.25e-7 Blood protein levels; CESC cis rs909002 0.849 rs10914458 chr1:32096746 T/C cg13919466 chr1:32135498 COL16A1 -0.47 -8.19 -0.45 1.15e-14 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06633814 chr18:77155955 NFATC1 0.56 6.05 0.35 4.87e-9 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs61492827 chr5:225774 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.65 0.33 4.24e-8 Breast cancer; CESC cis rs6460942 0.908 rs77034890 chr7:12244506 A/T cg06484146 chr7:12443880 VWDE -0.67 -6.56 -0.37 2.76e-10 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09071838 chr13:25497213 CENPJ -0.49 -7.03 -0.4 1.8e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7772486 0.902 rs2748500 chr6:146314852 C/A cg23711669 chr6:146136114 FBXO30 0.73 10.44 0.54 1.35e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.52 -6.45 -0.37 5.35e-10 Prudent dietary pattern; CESC cis rs1707322 1.000 rs785506 chr1:46540652 C/T cg03146154 chr1:46216737 IPP -0.7 -9.2 -0.49 1.08e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7193541 0.684 rs7191665 chr16:74688948 T/G cg01733217 chr16:74700730 RFWD3 1.05 20.16 0.78 2e-55 Multiple myeloma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02872018 chr2:192746213 NA -0.52 -6.47 -0.37 4.67e-10 Gut microbiome composition (summer); CESC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg07308232 chr7:1071921 C7orf50 -0.5 -6.98 -0.39 2.43e-11 Longevity;Endometriosis; CESC cis rs3749237 0.595 rs4955412 chr3:49418168 A/C cg07636037 chr3:49044803 WDR6 0.62 8.97 0.48 5.41e-17 Resting heart rate; CESC cis rs7592578 0.766 rs35818159 chr2:191409616 C/G cg10560079 chr2:191398806 TMEM194B -0.64 -5.35 -0.31 1.91e-7 Diastolic blood pressure; CESC cis rs7116495 0.609 rs2845860 chr11:71716661 C/T cg18441811 chr11:71824068 C11orf51 -0.83 -5.61 -0.33 4.97e-8 Severe influenza A (H1N1) infection; CESC cis rs9733 0.744 rs11204737 chr1:150847647 C/T cg18016565 chr1:150552671 MCL1 -0.35 -5.74 -0.33 2.55e-8 Tonsillectomy; CESC cis rs7208859 0.673 rs216420 chr17:28938508 C/T cg14008862 chr17:28927542 LRRC37B2 0.69 6.05 0.35 5.04e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.73 -0.33 2.75e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs933688 0.759 rs1423593 chr5:90752351 T/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.05 10.98 0.56 2.38e-23 Smoking behavior; CESC cis rs11958404 0.932 rs72816549 chr5:157417957 G/A cg05962755 chr5:157440814 NA 0.62 6.72 0.38 1.08e-10 IgG glycosylation; CESC cis rs1808579 0.935 rs4800488 chr18:21117571 C/A cg14672496 chr18:21087552 C18orf8 0.4 6.11 0.35 3.52e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC trans rs561341 1.000 rs8070262 chr17:30262467 A/G cg20587970 chr11:113659929 NA -0.8 -9.97 -0.52 4.47e-20 Hip circumference adjusted for BMI; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23539780 chr8:10696689 PINX1 -0.51 -6.97 -0.39 2.48e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs8068544 0.606 rs77681389 chr17:40154419 T/C cg26502583 chr17:39992600 KLHL10;NT5C3L -0.76 -6.07 -0.35 4.34e-9 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg20503657 chr10:835505 NA 0.85 8.61 0.47 6.57e-16 Eosinophil percentage of granulocytes; CESC cis rs761746 0.960 rs9956 chr22:32015450 T/G cg25791279 chr22:32026902 PISD 0.57 6.69 0.38 1.32e-10 Intelligence; CESC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg18230493 chr5:56204884 C5orf35 -0.7 -8.4 -0.46 2.71e-15 Initial pursuit acceleration; CESC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg02038168 chr22:39784481 NA -0.6 -7.6 -0.42 5.15e-13 Intelligence (multi-trait analysis); CESC cis rs6580649 0.941 rs10492080 chr12:48501411 A/G cg05342945 chr12:48394962 COL2A1 0.55 6.35 0.36 9.14e-10 Lung cancer; CESC cis rs6121246 0.697 rs6087716 chr20:30229040 C/T cg13852791 chr20:30311386 BCL2L1 0.77 7.87 0.44 9.26e-14 Mean corpuscular hemoglobin; CESC cis rs2262909 0.925 rs73019838 chr19:22247732 T/A cg11619707 chr19:22235551 ZNF257 0.32 5.12 0.3 5.9e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs6695640 0.820 rs6586539 chr1:17743669 C/T cg01904812 chr1:17746340 RCC2 0.35 5.07 0.3 7.53e-7 Mean platelet volume; CESC cis rs10129255 0.833 rs7156689 chr14:107224272 T/C cg23076370 chr14:107095027 NA -0.44 -5.25 -0.31 3.12e-7 Kawasaki disease; CESC cis rs763121 0.888 rs2235229 chr22:39124912 A/G cg06022373 chr22:39101656 GTPBP1 0.71 11.41 0.57 8.78e-25 Menopause (age at onset); CESC cis rs4268898 0.931 rs2111882 chr2:24434424 A/G cg20701182 chr2:24300061 SF3B14 -0.47 -5.51 -0.32 8.54e-8 Asthma; CESC cis rs11048434 0.736 rs1476911 chr12:9090859 C/T cg04155231 chr12:9217510 LOC144571 0.32 5.15 0.3 5.17e-7 Sjögren's syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18086592 chr12:13153464 HTR7P;HEBP1 0.57 6.07 0.35 4.53e-9 Gut microbiome composition (summer); CESC cis rs9467711 0.606 rs9379856 chr6:26366836 A/C cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.59e-7 Autism spectrum disorder or schizophrenia; CESC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg13114125 chr14:105738426 BRF1 -0.81 -10.13 -0.53 1.37e-20 Mean platelet volume;Platelet distribution width; CESC cis rs2014572 0.967 rs10413037 chr19:57771883 A/G cg24459738 chr19:57751996 ZNF805 -0.49 -6.85 -0.39 5.05e-11 Hyperactive-impulsive symptoms; CESC cis rs9790314 0.871 rs466626 chr3:161103629 A/C cg03342759 chr3:160939853 NMD3 -0.45 -6.04 -0.35 5.09e-9 Morning vs. evening chronotype; CESC cis rs7267979 1.000 rs453329 chr20:25440593 G/A cg08601574 chr20:25228251 PYGB 0.37 5.3 0.31 2.47e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs250677 0.687 rs250673 chr5:148445798 C/T cg18129178 chr5:148520854 ABLIM3 -0.51 -5.83 -0.34 1.58e-8 Breast cancer; CESC cis rs6120849 0.754 rs6120797 chr20:33606002 G/A cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs1707322 1.000 rs785470 chr1:46519622 C/A cg05343316 chr1:45956843 TESK2 -0.44 -5.44 -0.32 1.2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg22143856 chr6:28129313 ZNF389 0.41 5.32 0.31 2.25e-7 Parkinson's disease; CESC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.45 5.43 0.32 1.28e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18272703 chr1:1069929 NA -0.52 -6.36 -0.36 9.02e-10 Gut microbiome composition (summer); CESC trans rs11779988 0.543 rs379066 chr8:17881835 T/C cg02574033 chr7:141398961 KIAA1147 -0.42 -6.14 -0.35 2.97e-9 Breast cancer; CESC cis rs7208859 0.623 rs11656844 chr17:29060597 G/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2835872 0.758 rs1709832 chr21:39038167 A/C cg06728970 chr21:39037746 KCNJ6 0.29 5.43 0.32 1.29e-7 Electroencephalographic traits in alcoholism; CESC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.39e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg10523679 chr1:76189770 ACADM -0.65 -6.63 -0.38 1.85e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs116095464 0.614 rs62344292 chr5:244630 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.27 0.31 2.9e-7 Breast cancer; CESC cis rs67478160 0.583 rs12879612 chr14:104233618 T/A cg01849466 chr14:104193079 ZFYVE21 -0.48 -6.64 -0.38 1.75e-10 Schizophrenia; CESC cis rs12477438 0.501 rs9941561 chr2:99753829 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.48 0.69 6.26e-39 Chronic sinus infection; CESC cis rs7772486 0.713 rs2328704 chr6:146020494 T/C cg23711669 chr6:146136114 FBXO30 -0.82 -11.85 -0.59 2.76e-26 Lobe attachment (rater-scored or self-reported); CESC trans rs4791774 0.540 rs7218002 chr17:8923718 A/T cg02337062 chr3:49203509 CCDC71 0.47 6.17 0.35 2.51e-9 Nonsyndromic cleft lip with or without cleft palate; CESC cis rs9287719 0.967 rs3814388 chr2:10702099 A/T cg02196655 chr2:10830764 NOL10 -0.36 -5.42 -0.32 1.31e-7 Prostate cancer; CESC cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg22307029 chr19:49891270 CCDC155 0.55 6.66 0.38 1.59e-10 Multiple sclerosis; CESC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg07677032 chr17:61819896 STRADA 0.5 6.78 0.38 7.61e-11 Prudent dietary pattern; CESC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg14262678 chr6:151773367 RMND1;C6orf211 0.67 9.92 0.52 6.22e-20 Menarche (age at onset); CESC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg17376030 chr22:41985996 PMM1 -0.56 -6.2 -0.36 2.14e-9 Vitiligo; CESC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs12586317 0.513 rs74564132 chr14:35472882 C/T cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14128173 chr9:131115745 SLC27A4 -0.54 -6.54 -0.37 3.12e-10 Gut microbiome composition (summer); CESC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 9.52 0.5 1.16e-18 Mean platelet volume; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04232466 chr8:21988724 HR 0.47 6.52 0.37 3.52e-10 Systemic lupus erythematosus; CESC cis rs947211 0.948 rs1775143 chr1:205755550 C/T cg24503407 chr1:205819492 PM20D1 0.39 5.21 0.3 3.74e-7 Parkinson's disease; CESC trans rs2282526 0.615 rs162377 chr21:44926001 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.11 0.35 3.53e-9 Mean corpuscular hemoglobin; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg08052428 chr9:135996421 RALGDS 0.46 6.26 0.36 1.57e-9 Weight; CESC cis rs6466055 0.720 rs1204077 chr7:104984019 T/C cg04380332 chr7:105027541 SRPK2 0.43 5.6 0.33 5.33e-8 Schizophrenia; CESC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.27 0.76 2.4e-52 Height; CESC cis rs34779708 0.966 rs1213392 chr10:35430285 C/T cg04310649 chr10:35416472 CREM -0.5 -6.22 -0.36 1.93e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.23 -0.36 1.81e-9 Total body bone mineral density; CESC cis rs79839061 0.610 rs2279182 chr4:882625 T/G cg07828340 chr4:882639 GAK 1.07 8.55 0.47 9.76e-16 Intelligence (multi-trait analysis); CESC cis rs6752107 0.967 rs11680130 chr2:234157258 G/A cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.34 5.24 0.31 3.22e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs6060717 0.536 rs11167279 chr20:34509107 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -6.96 -0.39 2.63e-11 Hip circumference adjusted for BMI; CESC cis rs55788414 0.932 rs34110030 chr16:81185211 G/A cg06400318 chr16:81190750 PKD1L2 -0.61 -6.81 -0.39 6.38e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs6732160 0.588 rs13390460 chr2:73371476 G/A cg01422370 chr2:73384389 NA 0.56 8.81 0.48 1.72e-16 Intelligence (multi-trait analysis); CESC cis rs8017423 0.967 rs11621364 chr14:90709115 A/G cg14092571 chr14:90743983 NA -0.57 -8.44 -0.46 2.09e-15 Mortality in heart failure; CESC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg01171360 chr6:293285 DUSP22 -0.67 -8.82 -0.48 1.61e-16 Menopause (age at onset); CESC cis rs9457247 0.765 rs1322077 chr6:167424293 T/C cg07741184 chr6:167504864 NA 0.35 6.33 0.36 1.04e-9 Crohn's disease; CESC cis rs12477438 0.765 rs7571390 chr2:99626593 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -8.96 -0.48 5.91e-17 Chronic sinus infection; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08413366 chr10:75255930 PPP3CB 0.53 6.95 0.39 2.85e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg18230493 chr5:56204884 C5orf35 -0.7 -8.55 -0.47 9.85e-16 Initial pursuit acceleration; CESC cis rs7208859 0.623 rs34756112 chr17:29113016 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs644799 1.000 rs3748256 chr11:95521953 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.93 0.39 3.22e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9388451 0.839 rs4897157 chr6:126102981 A/T cg05901451 chr6:126070800 HEY2 -0.63 -9.05 -0.49 3.22e-17 Brugada syndrome; CESC cis rs8141529 0.732 rs2269577 chr22:29196757 G/C cg02153584 chr22:29168773 CCDC117 0.7 10.05 0.53 2.35e-20 Lymphocyte counts; CESC cis rs116979167 0.545 rs1706914 chr7:105196445 A/T cg13798780 chr7:105162888 PUS7 0.52 6.29 0.36 1.28e-9 Bipolar disorder (body mass index interaction); CESC cis rs7772486 0.875 rs10457792 chr6:146412415 T/C cg23711669 chr6:146136114 FBXO30 0.81 12.17 0.6 2.27e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg13206674 chr6:150067644 NUP43 0.4 5.47 0.32 1.02e-7 Lung cancer; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg08635242 chr17:28706081 CPD -0.53 -6.11 -0.35 3.49e-9 Gut microbiota (bacterial taxa); CESC cis rs6942756 1.000 rs6949950 chr7:128914818 G/A cg02491457 chr7:128862824 NA -0.7 -9.86 -0.52 9.97e-20 White matter hyperintensity burden; CESC cis rs9467711 0.606 rs34622023 chr6:26362119 A/T cg12826209 chr6:26865740 GUSBL1 0.62 5.4 0.32 1.45e-7 Autism spectrum disorder or schizophrenia; CESC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg14893161 chr1:205819251 PM20D1 0.44 6.12 0.35 3.29e-9 Prostate-specific antigen levels; CESC cis rs5769765 1.000 rs4824106 chr22:50267822 T/C cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs733592 0.507 rs56129148 chr12:48485530 T/C cg04545296 chr12:48745243 ZNF641 -0.29 -5.44 -0.32 1.19e-7 Plateletcrit; CESC cis rs5758659 0.652 rs133323 chr22:42405922 T/C cg04733989 chr22:42467013 NAGA 0.44 5.85 0.34 1.41e-8 Cognitive function; CESC cis rs7617773 0.539 rs2017858 chr3:48382282 G/T cg11946769 chr3:48343235 NME6 0.66 8.34 0.46 4.12e-15 Coronary artery disease; CESC cis rs7927771 0.524 rs10742820 chr11:47781057 C/T cg18512352 chr11:47633146 NA -0.35 -5.47 -0.32 1.03e-7 Subjective well-being; CESC trans rs9951602 0.512 rs12607561 chr18:76644284 G/A cg02800362 chr5:177631904 HNRNPAB 0.62 8.1 0.45 1.96e-14 Obesity-related traits; CESC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg23048001 chr7:2026167 MAD1L1 0.47 6.1 0.35 3.7e-9 Bipolar disorder and schizophrenia; CESC cis rs909674 0.818 rs8136980 chr22:39844574 G/A cg24399712 chr22:39784796 NA -0.82 -10.79 -0.55 9.65e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9399135 0.935 rs2150680 chr6:135347131 G/C cg24558204 chr6:135376177 HBS1L 0.52 7.29 0.41 3.48e-12 Red blood cell count; CESC cis rs2832191 0.967 rs2898160 chr21:30487496 A/G cg24692254 chr21:30365293 RNF160 -0.73 -10.87 -0.56 5.11e-23 Dental caries; CESC cis rs941873 0.805 rs10824747 chr10:81118464 T/C cg09469691 chr10:81107165 PPIF 0.55 7.3 0.41 3.43e-12 Height; CESC cis rs4666360 1.000 rs6725416 chr2:20336773 C/T cg23291376 chr2:20336282 NA -0.36 -6.06 -0.35 4.55e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel); CESC trans rs561341 1.000 rs8073186 chr17:30244956 T/C cg27661571 chr11:113659931 NA -0.65 -6.77 -0.38 8.15e-11 Hip circumference adjusted for BMI; CESC cis rs9788682 0.748 rs637137 chr15:78873976 T/A cg24631222 chr15:78858424 CHRNA5 0.81 10.17 0.53 9.9e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7267979 0.903 rs2474769 chr20:25248725 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.62 0.69 2.01e-39 Liver enzyme levels (alkaline phosphatase); CESC cis rs10779751 0.734 rs2791658 chr1:11127871 A/G cg08854313 chr1:11322531 MTOR 0.77 10.41 0.54 1.73e-21 Body mass index; CESC cis rs4595586 0.545 rs12828866 chr12:39391925 C/A cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg05552183 chr6:42928497 GNMT -0.76 -11.68 -0.58 1.03e-25 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7085104 0.632 rs3781287 chr10:104595420 A/C cg04362960 chr10:104952993 NT5C2 0.52 6.9 0.39 3.87e-11 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg26343298 chr8:95960752 TP53INP1 0.36 6.05 0.35 4.98e-9 Type 2 diabetes; CESC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg18876405 chr7:65276391 NA 0.69 9.68 0.51 3.58e-19 Aortic root size; CESC cis rs763121 0.853 rs1013338 chr22:38974154 C/A cg06544989 chr22:39130855 UNC84B 0.49 8.99 0.48 4.98e-17 Menopause (age at onset); CESC cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg17366294 chr4:99064904 C4orf37 -0.57 -8.06 -0.44 2.56e-14 Colonoscopy-negative controls vs population controls; CESC cis rs727505 1.000 rs34986416 chr7:124441017 A/G cg23710748 chr7:124431027 NA -0.49 -7.66 -0.43 3.43e-13 Lewy body disease; CESC cis rs2361718 0.500 rs8068856 chr17:78100731 A/G cg20811857 chr17:78079795 GAA -0.42 -6.09 -0.35 4.03e-9 Yeast infection; CESC cis rs9790314 0.846 rs4856714 chr3:160961824 T/C cg03342759 chr3:160939853 NMD3 -0.51 -7.37 -0.41 2.12e-12 Morning vs. evening chronotype; CESC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 13.06 0.63 1.98e-30 Platelet count; CESC cis rs7927771 0.542 rs6485775 chr11:47773518 A/G cg20307385 chr11:47447363 PSMC3 -0.56 -7.74 -0.43 2.15e-13 Subjective well-being; CESC cis rs796364 0.951 rs10931888 chr2:201022952 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.7 -6.78 -0.38 7.69e-11 Schizophrenia; CESC cis rs4474465 0.646 rs7937417 chr11:78284470 A/G cg27205649 chr11:78285834 NARS2 0.51 6.9 0.39 3.78e-11 Alzheimer's disease (survival time); CESC cis rs2742417 0.603 rs2253979 chr3:45773320 A/G cg04837898 chr3:45731254 SACM1L -0.46 -6.11 -0.35 3.5e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs2404602 0.740 rs34924128 chr15:76965169 T/G cg26408565 chr15:76604113 ETFA -0.39 -5.64 -0.33 4.39e-8 Blood metabolite levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01669482 chr16:25043131 NA -0.46 -6.64 -0.38 1.79e-10 Gambling; CESC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg06456125 chr7:65229604 NA 0.41 5.22 0.31 3.61e-7 Aortic root size; CESC cis rs7084402 0.565 rs4948522 chr10:60334575 T/C cg07615347 chr10:60278583 BICC1 0.42 6.09 0.35 3.97e-9 Refractive error; CESC trans rs7937682 0.889 rs7926485 chr11:111536670 G/A cg18187862 chr3:45730750 SACM1L 0.47 6.04 0.35 5.2e-9 Primary sclerosing cholangitis; CESC cis rs1832871 0.643 rs9456282 chr6:158724743 A/G cg07165851 chr6:158734300 TULP4 0.62 6.41 0.37 6.77e-10 Height; CESC cis rs4901869 0.966 rs12893803 chr14:59329655 T/C cg02291164 chr14:59296302 NA 0.44 7.45 0.42 1.36e-12 Panic disorder; CESC trans rs1814175 0.817 rs12277258 chr11:49940216 T/C cg03929089 chr4:120376271 NA -0.93 -16.26 -0.71 1.03e-41 Height; CESC cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.676 rs13195816 chr6:109598624 T/C cg01475377 chr6:109611718 NA -0.43 -6.66 -0.38 1.61e-10 Reticulocyte fraction of red cells; CESC cis rs977987 0.843 rs10459859 chr16:75381950 T/C cg03315344 chr16:75512273 CHST6 0.39 5.62 0.33 4.88e-8 Dupuytren's disease; CESC cis rs3806843 0.706 rs1089305 chr5:140066306 T/C cg26395211 chr5:140044315 WDR55 0.47 6.03 0.35 5.51e-9 Depressive symptoms (multi-trait analysis); CESC cis rs9549260 0.651 rs9549251 chr13:41228650 A/G cg21288729 chr13:41239152 FOXO1 0.65 8.51 0.46 1.32e-15 Red blood cell count; CESC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs6963495 0.745 rs75805443 chr7:105162828 A/G cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg14558114 chr2:88469736 THNSL2 0.57 5.4 0.31 1.5e-7 Plasma clusterin levels; CESC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg22800045 chr5:56110881 MAP3K1 0.81 9.91 0.52 6.85e-20 Initial pursuit acceleration; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg15919258 chr14:90849921 NA -0.4 -6.15 -0.35 2.78e-9 Vertical cup-disc ratio; CESC cis rs4808199 1.000 rs12977524 chr19:19568244 A/G cg03709012 chr19:19516395 GATAD2A 1.16 13.34 0.63 2.07e-31 Nonalcoholic fatty liver disease; CESC cis rs1669338 0.588 rs3804783 chr3:3184442 C/T cg16797762 chr3:3221439 CRBN -0.59 -6.2 -0.36 2.14e-9 White matter integrity; CESC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg03934478 chr11:495069 RNH1 0.55 5.31 0.31 2.37e-7 Body mass index; CESC cis rs830124 0.602 rs1375654 chr12:122385711 C/T cg22168489 chr12:122356033 WDR66 -0.38 -5.05 -0.3 8.27e-7 Urinary metabolites; CESC cis rs9303280 0.806 rs2872507 chr17:38040763 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.45 -0.32 1.13e-7 Self-reported allergy; CESC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg19592336 chr6:28129416 ZNF389 0.45 6.44 0.37 5.6e-10 Parkinson's disease; CESC cis rs847577 0.569 rs7804318 chr7:97796635 A/G cg24562669 chr7:97807699 LMTK2 -0.8 -13.09 -0.63 1.57e-30 Breast cancer; CESC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg12963246 chr6:28129442 ZNF389 0.5 6.4 0.37 6.93e-10 Parkinson's disease; CESC cis rs9814567 1.000 rs7426847 chr3:134267519 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9768139 0.935 rs10155946 chr7:158122116 C/T cg24154853 chr7:158122151 PTPRN2 -0.4 -6.41 -0.37 6.55e-10 Calcium levels; CESC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs7312933 0.510 rs61942483 chr12:42499538 T/A cg01256987 chr12:42539512 GXYLT1 -0.47 -7.29 -0.41 3.49e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg11859384 chr17:80120422 CCDC57 0.38 5.11 0.3 6.03e-7 Life satisfaction; CESC trans rs6445797 0.632 rs11130538 chr3:56700769 A/G cg15444621 chr13:113611794 NA 0.34 6.03 0.35 5.54e-9 Gastritis; CESC cis rs9914988 0.943 rs2046759 chr17:27138817 T/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs11083475 0.714 rs1471432 chr19:39260282 G/A cg07905965 chr19:39260460 NA 0.36 5.39 0.31 1.54e-7 Heart rate; CESC cis rs2014572 1.000 rs2014572 chr19:57760018 G/A cg24459738 chr19:57751996 ZNF805 -0.53 -7.48 -0.42 1.08e-12 Hyperactive-impulsive symptoms; CESC cis rs829883 0.966 rs249818 chr12:98896994 A/C cg25150519 chr12:98850993 NA 0.71 9.74 0.51 2.31e-19 Colorectal adenoma (advanced); CESC trans rs1829883 0.600 rs2948748 chr5:98742134 A/G cg23861655 chr4:57411219 NA 0.39 6.38 0.36 7.86e-10 Hemostatic factors and hematological phenotypes; CESC cis rs1050631 0.564 rs1785925 chr18:33727186 C/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.72e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg21644426 chr2:191273491 MFSD6 0.47 6.48 0.37 4.45e-10 Pulse pressure; CESC cis rs7772486 0.790 rs6917482 chr6:146243581 C/T cg05347473 chr6:146136440 FBXO30 -0.55 -7.05 -0.4 1.57e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg04111992 chr7:158790115 NA -0.33 -5.14 -0.3 5.26e-7 Facial morphology (factor 20); CESC cis rs55794721 0.509 rs4649085 chr1:25778832 G/A cg02931644 chr1:25747376 RHCE 0.46 7.97 0.44 4.84e-14 Plateletcrit;Mean corpuscular volume; CESC cis rs7208859 0.623 rs9911784 chr17:29124580 A/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6963495 0.818 rs73190183 chr7:105163022 G/A cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07822143 chr4:146019674 ABCE1;ANAPC10 -0.72 -8.83 -0.48 1.42e-16 Gut microbiome composition (summer); CESC cis rs897984 0.542 rs59061704 chr16:31062704 G/C cg02466173 chr16:30829666 NA -0.43 -7.37 -0.41 2.18e-12 Dementia with Lewy bodies; CESC cis rs9611565 0.879 rs4820437 chr22:41761290 T/C cg06481639 chr22:41940642 POLR3H -0.44 -5.15 -0.3 5.2e-7 Vitiligo; CESC cis rs7267979 1.000 rs7019 chr20:25278278 C/T cg08601574 chr20:25228251 PYGB 0.37 5.2 0.3 3.93e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs12476592 0.602 rs11125977 chr2:63809549 C/T cg17519650 chr2:63277830 OTX1 0.48 5.48 0.32 9.68e-8 Childhood ear infection; CESC cis rs1153858 1.000 rs12595087 chr15:45655232 A/G cg21132104 chr15:45694354 SPATA5L1 0.86 11.64 0.58 1.46e-25 Homoarginine levels; CESC cis rs10242455 0.702 rs73397447 chr7:99010949 G/T cg25640893 chr7:99214727 ZNF498 1.05 6.32 0.36 1.09e-9 Blood metabolite levels; CESC cis rs6502050 0.835 rs7406529 chr17:80080877 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.13 0.3 5.62e-7 Life satisfaction; CESC cis rs6834538 0.597 rs4834291 chr4:113482718 C/T cg05166686 chr4:113558556 LARP7;C4orf21 0.43 5.32 0.31 2.17e-7 Free thyroxine concentration; CESC cis rs4835473 0.832 rs55935372 chr4:144621779 A/G cg25736465 chr4:144833511 NA -0.41 -5.97 -0.34 7.55e-9 Immature fraction of reticulocytes; CESC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg04025307 chr7:1156635 C7orf50 0.49 7.92 0.44 6.39e-14 Longevity;Endometriosis; CESC cis rs9796 0.689 rs28409432 chr15:41447454 G/A cg20272979 chr15:41787780 ITPKA 0.34 5.12 0.3 6.01e-7 Menopause (age at onset); CESC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg05132306 chr1:1846340 CALML6 -0.32 -6.83 -0.39 5.89e-11 Body mass index; CESC cis rs3768617 0.510 rs2093984 chr1:183094314 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 13.4 0.64 1.29e-31 Fuchs's corneal dystrophy; CESC cis rs9929218 0.954 rs60302411 chr16:68824220 A/C cg02972257 chr16:68554789 NA 0.45 5.38 0.31 1.66e-7 Colorectal cancer; CESC trans rs61931739 0.534 rs6488189 chr12:33995865 C/T cg26384229 chr12:38710491 ALG10B 0.59 8.17 0.45 1.3e-14 Morning vs. evening chronotype; CESC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg02788857 chr8:22132959 PIWIL2 0.32 5.65 0.33 4.12e-8 Hypertriglyceridemia; CESC cis rs11792861 0.816 rs7027263 chr9:111699569 G/A cg13535736 chr9:111863775 C9orf5 -0.47 -6.26 -0.36 1.55e-9 Menarche (age at onset); CESC cis rs4728302 0.869 rs7792546 chr7:133595502 G/T cg10665199 chr7:133106180 EXOC4 0.4 5.55 0.32 7.05e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7973683 0.513 rs57316347 chr12:124389053 A/G cg00084347 chr12:124393913 DNAH10 0.27 5.21 0.3 3.81e-7 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs748404 0.578 rs478028 chr15:43610772 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.75 0.47 2.5e-16 Lung cancer; CESC cis rs3784262 1.000 rs12903551 chr15:58268372 C/T cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.07 -0.3 7.49e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs67311347 1.000 rs11539046 chr3:40503809 G/A cg01475735 chr3:40494733 NA 0.44 5.47 0.32 1.05e-7 Renal cell carcinoma; CESC cis rs2795502 1.000 rs3121279 chr10:43378449 T/A cg20628663 chr10:43360327 NA 0.52 6.14 0.35 3e-9 Blood protein levels; CESC cis rs7264396 0.563 rs2425086 chr20:34302873 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.7 0.38 1.23e-10 Total cholesterol levels; CESC cis rs977987 0.742 rs12928898 chr16:75462081 G/A cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg25019033 chr10:957182 NA -0.59 -6.44 -0.37 5.47e-10 Eosinophil percentage of granulocytes; CESC trans rs17685 0.664 rs9801113 chr7:75792031 C/T cg19862616 chr7:65841803 NCRNA00174 0.84 12.03 0.59 6.77e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs8017423 0.935 rs7160304 chr14:90752908 G/T cg14092571 chr14:90743983 NA -0.6 -9.06 -0.49 2.86e-17 Mortality in heart failure; CESC cis rs6460942 0.915 rs62447640 chr7:12488282 A/T cg02935154 chr7:12443704 VWDE -0.57 -5.94 -0.34 9.02e-9 Coronary artery disease; CESC cis rs6121246 0.909 rs6088962 chr20:30268184 C/T cg13852791 chr20:30311386 BCL2L1 0.8 7.34 0.41 2.62e-12 Mean corpuscular hemoglobin; CESC trans rs879500 0.653 rs4131805 chr18:26059112 T/C cg18984002 chr17:36876514 MLLT6 0.44 6.21 0.36 2.08e-9 Lung function (FVC); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13100218 chr1:117487539 PTGFRN -0.54 -6.05 -0.35 4.82e-9 Gut microbiome composition (summer); CESC cis rs6570726 0.935 rs366621 chr6:145861275 A/G cg05347473 chr6:146136440 FBXO30 0.47 6.19 0.36 2.29e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs6963495 0.818 rs73190183 chr7:105163022 G/A cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs727505 0.954 rs1525613 chr7:124658636 A/G cg23710748 chr7:124431027 NA -0.45 -6.98 -0.39 2.31e-11 Lewy body disease; CESC cis rs568617 0.716 rs111953392 chr11:65595697 G/A cg04055107 chr11:65626734 MUS81;CFL1 1.01 8.46 0.46 1.84e-15 Crohn's disease; CESC cis rs8062405 1.000 rs72793811 chr16:28839392 G/A cg08761264 chr16:28874980 SH2B1 -0.44 -5.36 -0.31 1.85e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9911578 0.935 rs420878 chr17:56709077 A/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.15 -0.4 8.32e-12 Intelligence (multi-trait analysis); CESC cis rs8060686 0.623 rs7201591 chr16:68086105 A/G cg26727032 chr16:67993705 SLC12A4 -0.59 -8.18 -0.45 1.22e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs863345 0.512 rs2852636 chr1:158586352 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -5.44 -0.32 1.24e-7 Pneumococcal bacteremia; CESC cis rs7542091 0.704 rs1883331 chr1:210043483 A/G cg22029157 chr1:209979665 IRF6 0.5 7.98 0.44 4.32e-14 Monobrow; CESC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg08392591 chr16:89556376 ANKRD11 -0.56 -7.56 -0.42 6.6e-13 Multiple myeloma (IgH translocation); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07590406 chr3:58292066 RPP14 -0.42 -6.12 -0.35 3.39e-9 Gambling; CESC cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg13298116 chr11:62369859 EML3;MTA2 0.62 9.27 0.49 6.6e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs992157 0.767 rs2382822 chr2:219173327 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.62 -8.23 -0.45 8.74e-15 Colorectal cancer; CESC cis rs2797160 0.684 rs1832937 chr6:125985934 A/G cg05901451 chr6:126070800 HEY2 0.45 6.69 0.38 1.35e-10 Endometrial cancer; CESC cis rs1018836 0.884 rs7008765 chr8:91632589 C/T cg16814680 chr8:91681699 NA -0.72 -9.98 -0.52 3.92e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs854765 0.718 rs12943500 chr17:17790588 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.46 -6.06 -0.35 4.57e-9 Total body bone mineral density; CESC cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg25019033 chr10:957182 NA -0.56 -6.07 -0.35 4.4e-9 Eosinophil percentage of granulocytes; CESC cis rs2302190 0.769 rs7211294 chr17:56462783 G/A cg25885038 chr17:56607967 SEPT4 -0.41 -5.49 -0.32 9.52e-8 Vitamin D levels; CESC cis rs9790314 0.875 rs7615592 chr3:160981548 A/C cg03342759 chr3:160939853 NMD3 -0.43 -5.54 -0.32 7.15e-8 Morning vs. evening chronotype; CESC cis rs7617480 0.648 rs6796790 chr3:48780317 G/A cg07636037 chr3:49044803 WDR6 0.82 12.17 0.6 2.33e-27 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs1969363 0.531 rs11495331 chr12:38110702 A/G cg26384229 chr12:38710491 ALG10B 0.39 5.29 0.31 2.61e-7 Morning vs. evening chronotype; CESC cis rs56104184 0.578 rs7254608 chr19:49395774 G/T cg21252483 chr19:49399788 TULP2 -0.39 -5.5 -0.32 9.11e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs2777491 1.000 rs316609 chr15:41743828 T/A cg02330683 chr15:41787940 ITPKA 0.47 7.08 0.4 1.26e-11 Ulcerative colitis; CESC cis rs13064411 0.696 rs6766615 chr3:113219342 T/C cg18753928 chr3:113234510 CCDC52 -0.5 -6.04 -0.35 5.2e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs1401999 0.674 rs562 chr3:183637845 T/C cg01324343 chr3:183735012 ABCC5 0.47 9.3 0.5 5.34e-18 Anterior chamber depth; CESC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.77 10.14 0.53 1.26e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg20503657 chr10:835505 NA 0.81 8.26 0.45 6.95e-15 Eosinophil percentage of granulocytes; CESC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -7.94 -0.44 5.65e-14 Personality dimensions; CESC cis rs9905704 0.836 rs302875 chr17:56767874 A/G cg12560992 chr17:57184187 TRIM37 -0.61 -7.14 -0.4 8.77e-12 Testicular germ cell tumor; CESC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.33e-10 Skin colour saturation; CESC cis rs926392 0.589 rs2019032 chr20:37680326 C/A cg16355469 chr20:37678765 NA 0.61 7.37 0.41 2.17e-12 Dialysis-related mortality; CESC cis rs7208859 0.623 rs79607958 chr17:28934548 T/G cg19761014 chr17:28927070 LRRC37B2 0.82 6.21 0.36 2.01e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9359856 0.564 rs17584290 chr6:90467114 T/G cg13799429 chr6:90582589 CASP8AP2 -0.61 -5.64 -0.33 4.36e-8 Bipolar disorder; CESC cis rs10242455 0.764 rs2740564 chr7:99295693 T/C cg07715041 chr7:99302981 CYP3A7 -0.44 -5.56 -0.32 6.73e-8 Blood metabolite levels; CESC cis rs2637266 0.562 rs35305451 chr10:78408479 A/G cg18941641 chr10:78392320 NA -0.32 -5.11 -0.3 6.16e-7 Pulmonary function; CESC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg08499158 chr17:42289980 UBTF -0.5 -6.39 -0.37 7.31e-10 Total body bone mineral density; CESC cis rs17001868 0.568 rs3788579 chr22:40742989 T/C cg07138101 chr22:40742427 ADSL 0.57 5.42 0.32 1.37e-7 Mammographic density (dense area); CESC cis rs7219021 0.926 rs11657940 chr17:46852616 G/A cg16584676 chr17:46985605 UBE2Z -0.56 -6.27 -0.36 1.48e-9 Schizophrenia or bipolar disorder; CESC cis rs477692 0.699 rs557311 chr10:131389484 A/G cg05714579 chr10:131428358 MGMT 0.45 5.88 0.34 1.21e-8 Response to temozolomide; CESC trans rs7618501 0.815 rs3819325 chr3:49843723 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.58 8.12 0.45 1.72e-14 Intelligence (multi-trait analysis); CESC cis rs3824867 0.920 rs3740685 chr11:47468791 C/T cg20307385 chr11:47447363 PSMC3 0.51 6.27 0.36 1.43e-9 Mean corpuscular hemoglobin; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19826439 chr1:226297528 NA -0.47 -6.7 -0.38 1.23e-10 Fibrinogen levels; CESC cis rs9457247 0.967 rs2015864 chr6:167381476 T/C cg07741184 chr6:167504864 NA -0.32 -5.89 -0.34 1.15e-8 Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11636714 chr8:42128950 IKBKB -0.43 -6.2 -0.36 2.13e-9 Fibrinogen levels; CESC cis rs4662945 0.603 rs1453147 chr2:130271510 A/C cg05903289 chr2:130345205 NA -0.36 -5.3 -0.31 2.45e-7 Response to cytidine analogues (gemcitabine); CESC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg23758822 chr17:41437982 NA 1.03 14.48 0.66 2.1e-35 Menopause (age at onset); CESC cis rs2637266 0.703 rs728435 chr10:78527897 T/A cg18941641 chr10:78392320 NA 0.39 7.55 0.42 6.84e-13 Pulmonary function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15980914 chr19:28297092 NA 0.5 6.63 0.38 1.89e-10 Fibrinogen levels; CESC cis rs17818399 0.749 rs13000560 chr2:46790997 G/T cg02822958 chr2:46747628 ATP6V1E2 0.45 5.24 0.31 3.31e-7 Height; CESC cis rs72634258 0.945 rs2294889 chr1:8075934 A/G cg00042356 chr1:8021962 PARK7 0.78 7.13 0.4 9.61e-12 Inflammatory bowel disease; CESC cis rs9818758 0.607 rs13077498 chr3:49313978 C/T cg00383909 chr3:49044727 WDR6 0.8 6.08 0.35 4.24e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg19163074 chr7:65112434 INTS4L2 -0.46 -5.05 -0.3 8.07e-7 Aortic root size; CESC trans rs11098499 0.580 rs12509234 chr4:120319434 T/C cg25214090 chr10:38739885 LOC399744 0.71 9.79 0.52 1.6e-19 Corneal astigmatism; CESC cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg08822215 chr16:89438651 ANKRD11 -0.37 -5.73 -0.33 2.75e-8 Multiple myeloma (IgH translocation); CESC cis rs7246657 0.891 rs7253114 chr19:37988725 G/A cg23950597 chr19:37808831 NA -0.56 -6.26 -0.36 1.51e-9 Coronary artery calcification; CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg05195085 chr7:157951403 PTPRN2 0.41 7.77 0.43 1.73e-13 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg11764359 chr7:65958608 NA -0.78 -11.22 -0.57 3.73e-24 Aortic root size; CESC cis rs10851478 0.872 rs7172906 chr15:49922775 C/G cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.2 0.3 3.95e-7 Oral cavity cancer; CESC cis rs9457247 0.534 rs9356551 chr6:167400345 T/C cg23791538 chr6:167370224 RNASET2 0.67 9.65 0.51 4.6e-19 Crohn's disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09755102 chr1:33283495 S100PBP;YARS 0.52 7.15 0.4 8.58e-12 Systemic lupus erythematosus; CESC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg05368731 chr17:41323189 NBR1 0.79 10.8 0.55 9.2e-23 Menopause (age at onset); CESC cis rs4237845 0.788 rs1962047 chr12:58292707 G/A cg00677455 chr12:58241039 CTDSP2 0.6 7.5 0.42 9.64e-13 Intelligence (multi-trait analysis); CESC cis rs4595586 0.545 rs6580894 chr12:39371951 A/G cg26384229 chr12:38710491 ALG10B 0.51 7.07 0.4 1.38e-11 Morning vs. evening chronotype; CESC cis rs763121 0.962 rs5757135 chr22:38952573 C/T cg06022373 chr22:39101656 GTPBP1 0.74 11.52 0.58 3.59e-25 Menopause (age at onset); CESC cis rs7560272 0.564 rs10496190 chr2:73638823 C/G cg20560298 chr2:73613845 ALMS1 0.39 5.63 0.33 4.61e-8 Schizophrenia; CESC cis rs9611565 0.694 rs202622 chr22:41825342 T/G cg06634786 chr22:41940651 POLR3H 0.71 7.08 0.4 1.28e-11 Vitiligo; CESC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg18252515 chr7:66147081 NA 0.45 5.88 0.34 1.23e-8 Aortic root size; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15340270 chr11:62420901 INTS5 -0.47 -6.47 -0.37 4.79e-10 Asthma; CESC cis rs12477438 0.501 rs6751927 chr2:99740175 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.09 0.7 4.08e-41 Chronic sinus infection; CESC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg05564831 chr3:52568323 NT5DC2 0.45 6.84 0.39 5.32e-11 Bipolar disorder; CESC cis rs9814567 0.928 rs6768323 chr3:134268737 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs75804782 0.521 rs72982598 chr2:239455052 G/A cg18131467 chr2:239335373 ASB1 -0.67 -5.69 -0.33 3.4e-8 Morning vs. evening chronotype;Chronotype; CESC trans rs9467711 0.659 rs35555795 chr6:26509382 C/T cg06606381 chr12:133084897 FBRSL1 -0.96 -7.07 -0.4 1.39e-11 Autism spectrum disorder or schizophrenia; CESC cis rs9888739 1.000 rs9938063 chr16:31302938 C/T cg15817542 chr16:31343056 ITGAM 0.42 5.24 0.31 3.27e-7 Systemic lupus erythematosus; CESC cis rs3213545 0.700 rs10849829 chr12:121470256 A/G cg02403541 chr12:121454288 C12orf43 -0.65 -9.35 -0.5 3.9e-18 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs7582720 1.000 rs72932561 chr2:203848402 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs1167827 0.680 rs1167796 chr7:75173180 C/T cg09988129 chr7:74988866 PMS2L2;STAG3L1 -0.47 -5.94 -0.34 9.11e-9 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg03467027 chr4:99064603 C4orf37 0.45 5.67 0.33 3.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg03647317 chr4:187891568 NA -0.39 -5.79 -0.34 1.98e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7072216 0.763 rs7091709 chr10:100167605 G/A cg26618903 chr10:100175079 PYROXD2 -0.35 -5.34 -0.31 1.95e-7 Metabolite levels; CESC cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg05347473 chr6:146136440 FBXO30 0.59 7.61 0.42 4.79e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs6963495 0.615 rs2697021 chr7:105151029 A/C cg19920283 chr7:105172520 RINT1 0.53 6.19 0.36 2.3e-9 Bipolar disorder (body mass index interaction); CESC cis rs17039065 1.000 rs75264077 chr4:109393185 T/G cg16022748 chr4:109541635 LOC285456;RPL34 0.64 5.41 0.32 1.44e-7 Gut microbiome composition (summer); CESC cis rs863345 0.647 rs923663 chr1:158507732 A/T cg12129480 chr1:158549410 OR10X1 0.36 7.25 0.41 4.44e-12 Pneumococcal bacteremia; CESC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg13628971 chr7:2884303 GNA12 0.64 8.77 0.47 2.21e-16 Height; CESC cis rs4409675 0.576 rs6598912 chr1:28233289 C/T cg23691781 chr1:28212827 C1orf38 0.27 5.51 0.32 8.54e-8 Corneal astigmatism; CESC cis rs2180341 0.960 rs7756884 chr6:127684018 A/G cg24812749 chr6:127587940 RNF146 1.05 15.07 0.68 1.77e-37 Breast cancer; CESC cis rs60843830 1.000 rs11553746 chr2:272203 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.16 0.53 1.04e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9611565 0.765 rs132907 chr22:41801268 A/C cg17376030 chr22:41985996 PMM1 -0.68 -7.12 -0.4 1.02e-11 Vitiligo; CESC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg02038168 chr22:39784481 NA 0.54 6.59 0.38 2.32e-10 Intelligence (multi-trait analysis); CESC cis rs1879734 0.731 rs72660653 chr1:54157283 G/C cg23596471 chr1:54105337 GLIS1 0.33 5.51 0.32 8.53e-8 Mitral valve prolapse; CESC cis rs7584330 0.910 rs880932 chr2:238396963 A/G cg14458575 chr2:238380390 NA 0.7 10.44 0.54 1.34e-21 Prostate cancer; CESC cis rs2011503 0.843 rs2860494 chr19:19470426 T/C cg11584989 chr19:19387371 SF4 -0.64 -7.52 -0.42 8.54e-13 Bipolar disorder; CESC cis rs1707322 1.000 rs1612419 chr1:46546945 T/C cg03146154 chr1:46216737 IPP -0.73 -9.53 -0.51 1.06e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs672059 1.000 rs546183 chr1:183157753 A/G ch.1.3577855R chr1:183094577 LAMC1 0.54 6.97 0.39 2.51e-11 Hypertriglyceridemia; CESC cis rs6460942 0.597 rs6961238 chr7:12535428 C/T cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs9790314 0.540 rs9844862 chr3:161076188 G/A cg03342759 chr3:160939853 NMD3 -0.41 -5.95 -0.34 8.38e-9 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs12973672 0.812 rs10421096 chr19:35764559 C/T cg12095397 chr19:35769544 USF2 0.49 5.81 0.34 1.77e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9325144 0.505 rs10785560 chr12:38636622 C/T cg26384229 chr12:38710491 ALG10B 0.68 10.93 0.56 3.49e-23 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04150382 chr12:121533801 NA -0.51 -6.22 -0.36 1.89e-9 Gut microbiome composition (summer); CESC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs752010 0.644 rs6700390 chr1:42112554 A/G cg06885757 chr1:42089581 HIVEP3 0.49 7.8 0.43 1.42e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg12463550 chr7:65579703 CRCP 0.49 6.21 0.36 2.07e-9 Aortic root size; CESC cis rs4629180 0.586 rs1995826 chr2:102129420 A/G cg04415270 chr2:102091202 RFX8 0.34 5.71 0.33 3.02e-8 Chronic rhinosinusitis with nasal polyps; CESC cis rs950776 0.518 rs12914694 chr15:78814444 G/A cg24631222 chr15:78858424 CHRNA5 -0.43 -5.51 -0.32 8.36e-8 Sudden cardiac arrest; CESC cis rs3540 0.554 rs12443252 chr15:91064690 C/T cg22089800 chr15:90895588 ZNF774 -0.63 -8.22 -0.45 8.89e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs67311347 1.000 rs73076046 chr3:40447724 C/T cg09455208 chr3:40491958 NA 0.52 8.6 0.47 7.23e-16 Renal cell carcinoma; CESC cis rs6502050 0.835 rs4789666 chr17:80162276 C/T cg23985595 chr17:80112537 CCDC57 -0.4 -6.48 -0.37 4.35e-10 Life satisfaction; CESC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg14393609 chr7:65229607 NA -0.46 -6.14 -0.35 2.97e-9 Aortic root size; CESC cis rs11098499 0.863 rs3733525 chr4:120447048 A/G cg24375607 chr4:120327624 NA 0.43 5.22 0.31 3.68e-7 Corneal astigmatism; CESC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg24549020 chr5:56110836 MAP3K1 0.67 7.71 0.43 2.56e-13 Initial pursuit acceleration; CESC trans rs948562 0.690 rs75365860 chr11:58169496 C/G cg24637035 chr12:120445227 CCDC64 -0.49 -6.13 -0.35 3.26e-9 Lymphoma; CESC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg02574844 chr11:5959923 NA 0.51 8.06 0.44 2.7e-14 DNA methylation (variation); CESC cis rs11098499 0.687 rs71610270 chr4:120287436 A/G cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg16405210 chr4:1374714 KIAA1530 -0.94 -13.46 -0.64 8.05e-32 Longevity; CESC cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9831754 0.704 rs9823412 chr3:78457646 T/C cg06138941 chr3:78371609 NA -0.49 -6.11 -0.35 3.54e-9 Calcium levels; CESC cis rs6991838 0.584 rs3765205 chr8:66517486 C/T cg13398993 chr8:66546079 ARMC1 -0.46 -5.65 -0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs7191439 0.858 rs4238685 chr16:88775220 T/C cg27087555 chr16:88793112 FAM38A -1.32 -10.7 -0.55 1.9e-22 Plateletcrit; CESC cis rs2637266 0.599 rs2395425 chr10:78461920 C/T cg18941641 chr10:78392320 NA 0.4 7.1 0.4 1.13e-11 Pulmonary function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01911186 chr12:12765398 CREBL2 0.54 7.27 0.41 3.94e-12 Gut microbiota (bacterial taxa); CESC cis rs1153858 1.000 rs4625670 chr15:45652926 C/T cg21132104 chr15:45694354 SPATA5L1 0.85 11.64 0.58 1.47e-25 Homoarginine levels; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg01987347 chr13:111567478 ANKRD10 -0.44 -6.09 -0.35 3.94e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs763014 0.931 rs7192508 chr16:630367 C/T cg09263875 chr16:632152 PIGQ 0.67 11.07 0.56 1.14e-23 Height; CESC cis rs17021463 0.617 rs34872198 chr4:95326957 T/C cg11021082 chr4:95130006 SMARCAD1 0.49 6.63 0.38 1.92e-10 Testicular germ cell tumor; CESC trans rs11148252 0.574 rs2038826 chr13:53280013 G/A cg18335740 chr13:41363409 SLC25A15 0.52 7.11 0.4 1.1e-11 Lewy body disease; CESC cis rs1915146 0.546 rs2681919 chr10:126859029 A/G cg23000734 chr10:126850823 CTBP2 0.53 8.02 0.44 3.36e-14 Menarche (age at onset); CESC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg08499158 chr17:42289980 UBTF -0.52 -6.47 -0.37 4.74e-10 Total body bone mineral density; CESC cis rs4835473 0.831 rs1912743 chr4:144914858 C/G cg25736465 chr4:144833511 NA 0.43 6.38 0.36 8.02e-10 Immature fraction of reticulocytes; CESC cis rs10927875 0.631 rs28579893 chr1:16347534 A/G cg21385522 chr1:16154831 NA 0.59 6.95 0.39 2.82e-11 Dilated cardiomyopathy; CESC cis rs4253772 0.530 rs9615961 chr22:46754993 T/C cg24881330 chr22:46731750 TRMU 0.8 5.72 0.33 2.91e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6088590 0.561 rs6087605 chr20:33180624 G/T cg24642439 chr20:33292090 TP53INP2 0.63 8.39 0.46 3.03e-15 Coronary artery disease; CESC cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg00149659 chr3:10157352 C3orf10 0.89 9.53 0.51 1.08e-18 Alzheimer's disease; CESC cis rs2011503 1.000 rs111406321 chr19:19637437 G/A cg11584989 chr19:19387371 SF4 0.61 7.03 0.4 1.79e-11 Bipolar disorder; CESC cis rs6584283 0.875 rs10748783 chr10:101285872 C/A cg09788492 chr10:101292477 NKX2-3 0.34 6.34 0.36 9.91e-10 Ulcerative colitis; CESC cis rs7809950 0.817 rs2712195 chr7:107127496 C/T cg23024343 chr7:107201750 COG5 -0.57 -7.42 -0.41 1.55e-12 Coronary artery disease; CESC cis rs2243480 1.000 rs316329 chr7:65608416 A/C cg18252515 chr7:66147081 NA -1.44 -14.38 -0.66 4.77e-35 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08692210 chr3:52188851 WDR51A 0.6 6.79 0.38 7.29e-11 Gut microbiome composition (summer); CESC cis rs1707322 0.717 rs1135812 chr1:46095272 T/C cg03146154 chr1:46216737 IPP 0.81 11.43 0.57 7.16e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs3741151 0.773 rs73544783 chr11:73221256 C/G cg17517138 chr11:73019481 ARHGEF17 0.98 7.25 0.41 4.61e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs6424115 0.760 rs2999566 chr1:24051124 A/G cg15997130 chr1:24165203 NA 0.42 5.65 0.33 4.11e-8 Immature fraction of reticulocytes; CESC cis rs17376456 0.825 rs28645862 chr5:93233128 G/C cg21475434 chr5:93447410 FAM172A 0.77 6.77 0.38 8.36e-11 Diabetic retinopathy; CESC cis rs2367563 1.000 rs7315571 chr12:96058277 A/G cg19013339 chr12:96052514 NTN4 0.35 5.15 0.3 4.97e-7 Allergic dermatitis (nickel); CESC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.87 9.14 0.49 1.7e-17 Platelet count; CESC cis rs739401 0.572 rs739399 chr11:3016452 A/G cg25174290 chr11:3078921 CARS 0.51 7.05 0.4 1.52e-11 Longevity; CESC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4604732 0.631 rs34924545 chr1:247626892 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.53e-8 Colonoscopy-negative controls vs population controls; CESC cis rs17376456 0.825 rs13171131 chr5:93223028 C/T cg25358565 chr5:93447407 FAM172A 1.11 10.53 0.54 6.8e-22 Diabetic retinopathy; CESC cis rs9910055 0.529 rs575798 chr17:42181796 A/C cg13607699 chr17:42295918 UBTF -0.49 -6.0 -0.35 6.38e-9 Total body bone mineral density; CESC cis rs898097 0.801 rs68141193 chr17:80878816 C/T cg05255149 chr17:80675120 FN3KRP -0.44 -5.16 -0.3 4.82e-7 Breast cancer; CESC cis rs9926296 0.542 rs12599531 chr16:89909401 C/T cg04287289 chr16:89883240 FANCA -0.56 -7.25 -0.41 4.5e-12 Vitiligo; CESC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg09699651 chr6:150184138 LRP11 0.4 5.04 0.3 8.58e-7 Lung cancer; CESC cis rs7208859 0.573 rs7214313 chr17:29138596 T/C cg13385521 chr17:29058706 SUZ12P 0.78 6.41 0.37 6.5e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs60843830 1.000 rs3791221 chr2:226933 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 8.04 0.44 2.92e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7520050 0.743 rs61789988 chr1:46085242 G/C cg03146154 chr1:46216737 IPP -0.47 -6.14 -0.35 2.94e-9 Red blood cell count;Reticulocyte count; CESC cis rs8064299 0.597 rs2053748 chr17:72775911 A/G cg25054828 chr17:72772726 NAT9;TMEM104 -0.85 -14.15 -0.66 2.98e-34 Monocyte count; CESC cis rs3126085 0.935 rs3126094 chr1:152308243 T/C cg03465714 chr1:152285911 FLG 0.43 5.26 0.31 2.94e-7 Atopic dermatitis; CESC cis rs7312933 0.558 rs11181467 chr12:42765250 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.34 0.36 9.95e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs80130819 0.748 rs1387255 chr12:48648943 C/T cg05342945 chr12:48394962 COL2A1 -0.51 -5.37 -0.31 1.71e-7 Prostate cancer; CESC cis rs7208859 0.673 rs73263981 chr17:28920502 A/G cg17105886 chr17:28927953 LRRC37B2 0.6 5.17 0.3 4.56e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7071206 0.740 rs2048781 chr10:79422975 T/C cg07817648 chr10:79422355 NA -0.82 -10.39 -0.54 2.02e-21 Bone mineral density; CESC cis rs10751667 1.000 rs6597965 chr11:964476 A/G cg06064525 chr11:970664 AP2A2 -0.38 -6.73 -0.38 1.06e-10 Alzheimer's disease (late onset); CESC cis rs208520 0.874 rs208517 chr6:66947040 G/T cg07460842 chr6:66804631 NA -0.9 -10.89 -0.56 4.59e-23 Exhaled nitric oxide output; CESC cis rs9916302 0.706 rs28482878 chr17:37497100 A/G cg07936489 chr17:37558343 FBXL20 0.88 9.63 0.51 5.22e-19 Glomerular filtration rate (creatinine); CESC cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg23711669 chr6:146136114 FBXO30 0.96 14.91 0.68 6.19e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs727563 0.552 rs4822045 chr22:41985958 C/A cg17376030 chr22:41985996 PMM1 0.81 8.45 0.46 1.98e-15 Crohn's disease;Inflammatory bowel disease; CESC cis rs4561483 0.583 rs11647580 chr16:11957609 G/C cg08843971 chr16:11963173 GSPT1 0.46 6.34 0.36 1.01e-9 Testicular germ cell tumor; CESC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg18876405 chr7:65276391 NA 0.48 6.31 0.36 1.16e-9 Aortic root size; CESC cis rs2439831 0.702 rs3784275 chr15:44091386 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.15 0.3 5.02e-7 Lung cancer in ever smokers; CESC cis rs9611565 0.921 rs761366 chr22:41744022 C/G cg06481639 chr22:41940642 POLR3H -0.64 -6.77 -0.38 8.31e-11 Vitiligo; CESC cis rs730566 0.640 rs6442112 chr3:48316034 A/G cg07636037 chr3:49044803 WDR6 0.41 5.35 0.31 1.92e-7 Prion diseases; CESC cis rs6963495 0.818 rs6957192 chr7:105150255 A/C cg13798780 chr7:105162888 PUS7 -0.76 -8.02 -0.44 3.38e-14 Bipolar disorder (body mass index interaction); CESC cis rs9811920 0.638 rs704581 chr3:99556160 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.62 -10.12 -0.53 1.44e-20 Axial length; CESC cis rs2250402 0.510 rs2291619 chr15:40329033 C/T cg01081584 chr15:40268610 EIF2AK4 0.62 6.08 0.35 4.11e-9 Corneal curvature; CESC cis rs7246657 1.000 rs7247672 chr19:37743928 A/G cg23950597 chr19:37808831 NA -0.61 -6.37 -0.36 8.38e-10 Coronary artery calcification; CESC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg24562669 chr7:97807699 LMTK2 0.48 6.92 0.39 3.3e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs4481887 0.927 rs4405158 chr1:248490647 A/C cg00666640 chr1:248458726 OR2T12 0.36 6.17 0.35 2.56e-9 Common traits (Other); CESC cis rs479844 1.000 rs479844 chr11:65551957 A/G cg08755490 chr11:65554678 OVOL1 0.51 6.68 0.38 1.41e-10 Allergic disease (asthma, hay fever or eczema);Atopic march;Atopic dermatitis; CESC cis rs4689388 0.926 rs4343789 chr4:6285228 C/G cg14416269 chr4:6271139 WFS1 0.49 8.41 0.46 2.63e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg11644478 chr21:40555479 PSMG1 1.04 17.32 0.73 1.85e-45 Cognitive function; CESC cis rs2832191 0.671 rs2409332 chr21:30512779 G/A cg08807101 chr21:30365312 RNF160 -0.53 -6.24 -0.36 1.76e-9 Dental caries; CESC cis rs1691799 0.899 rs1168299 chr12:66736074 C/G cg16791601 chr12:66731901 HELB -0.78 -14.03 -0.65 8.41e-34 White blood cell count (basophil); CESC cis rs10924309 0.889 rs10924308 chr1:245858131 C/T cg00036263 chr1:245852353 KIF26B -0.44 -5.36 -0.31 1.83e-7 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs1801251 1.000 rs56777991 chr2:233635388 A/C cg08000102 chr2:233561755 GIGYF2 0.65 9.23 0.49 9.15e-18 Coronary artery disease; CESC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg11247378 chr22:39784982 NA -0.62 -9.11 -0.49 2.11e-17 Intelligence (multi-trait analysis); CESC cis rs77741769 0.571 rs3897746 chr12:121324727 A/G cg02419362 chr12:121203948 SPPL3 0.34 5.58 0.32 5.97e-8 Mean corpuscular volume; CESC cis rs2635047 1.000 rs2684825 chr18:44666415 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 5.98 0.34 7.34e-9 Educational attainment; CESC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.33 0.31 2.07e-7 Tonsillectomy; CESC cis rs9303401 0.659 rs714959 chr17:56628601 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.0 12.44 0.61 2.75e-28 Cognitive test performance; CESC cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg03060546 chr3:49711283 APEH 0.55 6.8 0.39 7.11e-11 Parkinson's disease; CESC cis rs116095464 0.510 rs10057501 chr5:239545 T/C cg22857025 chr5:266934 NA -1.29 -18.69 -0.75 2.75e-50 Breast cancer; CESC cis rs4330281 0.715 rs7609916 chr3:17804464 A/G cg20981856 chr3:17787350 NA 0.36 5.1 0.3 6.56e-7 Schizophrenia; CESC cis rs6754311 0.551 rs9287442 chr2:136522710 A/G cg07169764 chr2:136633963 MCM6 -0.73 -9.28 -0.5 6.09e-18 Mosquito bite size; CESC cis rs796364 0.616 rs6710393 chr2:200697246 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.59 5.67 0.33 3.73e-8 Schizophrenia; CESC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.83 8.4 0.46 2.81e-15 Platelet count; CESC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg16743903 chr16:89593216 SPG7 -0.43 -5.53 -0.32 7.85e-8 Multiple myeloma (IgH translocation); CESC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg04282206 chr17:62833786 PLEKHM1P 0.55 6.41 0.37 6.72e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2070677 0.542 rs7086127 chr10:135393731 T/C cg20169779 chr10:135381914 SYCE1 -0.76 -10.07 -0.53 2.11e-20 Gout; CESC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg21770322 chr7:97807741 LMTK2 0.54 8.13 0.45 1.67e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs2777491 0.874 rs1655556 chr15:41777935 A/C cg18705301 chr15:41695430 NDUFAF1 -0.69 -10.64 -0.55 2.98e-22 Ulcerative colitis; CESC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg07343612 chr16:622815 PIGQ -0.57 -8.32 -0.46 4.64e-15 Height; CESC cis rs4975616 0.869 rs370348 chr5:1331219 A/G cg06550200 chr5:1325588 CLPTM1L -0.7 -11.17 -0.57 5.42e-24 Lung cancer; CESC cis rs644799 0.965 rs565771 chr11:95644179 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.84 12.77 0.62 1.95e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9303280 0.806 rs11078927 chr17:38064405 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.11 -0.3 6.07e-7 Self-reported allergy; CESC cis rs9549367 0.789 rs3850451 chr13:113905812 C/G cg00898013 chr13:113819073 PROZ -0.56 -7.64 -0.42 4.01e-13 Platelet distribution width; CESC cis rs7618501 1.000 rs695238 chr3:49869158 A/C cg24308560 chr3:49941425 MST1R -0.52 -6.97 -0.39 2.55e-11 Intelligence (multi-trait analysis); CESC cis rs2247341 0.965 rs2854921 chr4:1715250 C/T cg07465881 chr4:1713556 SLBP -0.54 -6.75 -0.38 9.2e-11 Hip circumference adjusted for BMI;Height; CESC cis rs909002 0.800 rs3134718 chr1:32089839 C/T cg13919466 chr1:32135498 COL16A1 -0.46 -8.29 -0.45 5.77e-15 Intelligence (multi-trait analysis); CESC cis rs3820068 0.581 rs6666373 chr1:15939884 A/T cg13390004 chr1:15929781 NA 0.37 5.96 0.34 8.08e-9 Systolic blood pressure; CESC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg10295955 chr4:187884368 NA -1.08 -23.24 -0.82 6.56e-66 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15304928 chr1:201123562 TMEM9 -0.58 -6.52 -0.37 3.61e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02453779 chr11:105948520 AASDHPPT;KBTBD3 0.54 6.48 0.37 4.54e-10 Gut microbiome composition (summer); CESC cis rs372883 0.600 rs2832295 chr21:30739843 C/T cg08807101 chr21:30365312 RNF160 0.46 5.31 0.31 2.28e-7 Pancreatic cancer; CESC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg24060327 chr5:131705240 SLC22A5 0.8 11.21 0.57 3.88e-24 Breast cancer; CESC cis rs28647808 0.881 rs28622217 chr9:136267323 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC cis rs1163251 0.837 rs592762 chr1:120247355 A/G cg19096424 chr1:120255104 PHGDH 0.52 6.67 0.38 1.52e-10 Blood metabolite levels; CESC cis rs2273669 0.588 rs79465564 chr6:109350290 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.06 -0.35 4.74e-9 Prostate cancer; CESC cis rs9733 0.519 rs1134067 chr1:150721175 G/T cg04414720 chr1:150670196 GOLPH3L 0.59 7.82 0.43 1.29e-13 Tonsillectomy; CESC cis rs34779708 0.931 rs17582416 chr10:35287650 A/C cg03585969 chr10:35415529 CREM 0.6 7.43 0.42 1.54e-12 Inflammatory bowel disease;Crohn's disease; CESC cis rs72772090 0.634 rs17402639 chr5:96107005 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -5.7 -0.33 3.24e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg12963246 chr6:28129442 ZNF389 0.53 6.91 0.39 3.61e-11 Parkinson's disease; CESC trans rs848353 0.901 rs73424667 chr7:108596103 T/C cg03555276 chr13:113260139 NA 0.56 6.03 0.35 5.42e-9 Smoking behavior; CESC cis rs4664308 0.935 rs6744567 chr2:160933781 C/G cg03641300 chr2:160917029 PLA2R1 -0.67 -9.84 -0.52 1.11e-19 Idiopathic membranous nephropathy; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05051117 chr1:205719564 NUCKS1 -0.5 -6.41 -0.37 6.79e-10 Ulcerative colitis; CESC cis rs7402982 0.934 rs8027457 chr15:99204101 A/G cg03437748 chr15:99193247 IGF1R 0.73 11.64 0.58 1.45e-25 Birth weight; CESC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs1322639 0.614 rs6908401 chr6:169564716 A/C cg04662567 chr6:169592167 NA 0.47 5.09 0.3 6.8e-7 Pulse pressure; CESC cis rs1801251 0.896 rs6719061 chr2:233695885 C/T cg25237894 chr2:233734115 C2orf82 -0.37 -6.57 -0.37 2.58e-10 Coronary artery disease; CESC cis rs6089584 0.606 rs2273989 chr20:60579138 G/A cg24733560 chr20:60626293 TAF4 0.44 6.56 0.37 2.88e-10 Body mass index; CESC cis rs12618769 0.597 rs3754885 chr2:99121708 G/T cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.67 0.38 1.47e-10 Electroencephalogram traits; CESC cis rs10779751 0.770 rs1417131 chr1:11191922 T/C cg08854313 chr1:11322531 MTOR -0.72 -8.53 -0.46 1.1e-15 Body mass index; CESC cis rs10504073 0.669 rs11779189 chr8:50030592 C/G cg00325661 chr8:49890786 NA -0.5 -7.48 -0.42 1.06e-12 Blood metabolite ratios; CESC cis rs861020 0.771 rs661849 chr1:210001233 C/T cg05527609 chr1:210001259 C1orf107 1.1 15.21 0.68 5.39e-38 Orofacial clefts; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01708236 chr6:44233446 NFKBIE 0.51 6.65 0.38 1.69e-10 Gut microbiota (bacterial taxa); CESC cis rs2625529 0.652 rs2929525 chr15:72287856 G/A cg16672083 chr15:72433130 SENP8 0.42 6.3 0.36 1.27e-9 Red blood cell count; CESC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.62 7.84 0.43 1.09e-13 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02079951 chr2:54013962 LOC100302652;ASB3;ERLEC1 0.64 6.93 0.39 3.15e-11 Gut microbiome composition (summer); CESC cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg20503657 chr10:835505 NA 0.84 8.51 0.46 1.32e-15 Eosinophil percentage of granulocytes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg13930080 chr1:23494472 LUZP1 -0.48 -6.05 -0.35 4.86e-9 Asthma; CESC trans rs6414928 0.516 rs10155587 chr5:25941938 A/T cg17053223 chr7:94535617 PPP1R9A -0.55 -6.02 -0.35 5.92e-9 Facial morphology (factor 5, width of mouth relative to central midface); CESC cis rs425277 0.585 rs3107143 chr1:2045372 G/C cg24578937 chr1:2090814 PRKCZ -0.34 -6.01 -0.35 5.99e-9 Height; CESC cis rs7914558 1.000 rs943036 chr10:104836047 T/C cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.51e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs644799 0.562 rs1254989 chr11:95508121 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.64 9.07 0.49 2.67e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs5758659 0.652 rs133324 chr22:42406371 C/A cg15557168 chr22:42548783 NA -0.42 -6.25 -0.36 1.59e-9 Cognitive function; CESC cis rs7091068 0.671 rs620890 chr10:95405424 G/A cg20715218 chr10:95462985 C10orf4 -0.51 -5.37 -0.31 1.76e-7 Urinary tract infection frequency; CESC cis rs3862260 0.509 rs7552885 chr1:120164966 C/T cg11530693 chr1:120165357 ZNF697 0.69 10.58 0.55 4.58e-22 Systemic lupus erythematosus; CESC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg12034118 chr1:209979487 IRF6 0.42 5.31 0.31 2.37e-7 Cleft lip with or without cleft palate; CESC cis rs7914558 0.966 rs7908280 chr10:104816947 C/G cg08650961 chr10:104748594 CNNM2 0.31 5.18 0.3 4.44e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs748404 0.660 rs690367 chr15:43748304 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.51 -7.88 -0.44 8.28e-14 Lung cancer; CESC cis rs8103278 0.864 rs2070737 chr19:46282890 A/T cg11657440 chr19:46296263 DMWD -0.62 -7.75 -0.43 1.96e-13 Coronary artery disease; CESC cis rs644148 0.867 rs2571060 chr19:44971647 C/G cg15540054 chr19:45004280 ZNF180 -0.72 -8.77 -0.47 2.23e-16 Personality dimensions; CESC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg21548813 chr6:291882 DUSP22 -0.46 -6.05 -0.35 4.84e-9 Menopause (age at onset); CESC cis rs6088580 0.634 rs2378133 chr20:32919505 C/G cg06115741 chr20:33292138 TP53INP2 -0.43 -5.5 -0.32 8.96e-8 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18003189 chr10:30723096 MAP3K8 0.58 6.83 0.39 5.92e-11 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg12463550 chr7:65579703 CRCP 0.57 7.19 0.4 6.64e-12 Aortic root size; CESC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.64 0.33 4.28e-8 Bipolar disorder; CESC cis rs10089 1.000 rs3792866 chr5:127479900 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.77 10.14 0.53 1.26e-20 Ileal carcinoids; CESC cis rs1707322 1.000 rs7553924 chr1:46352624 T/C cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11227306 0.934 rs7940691 chr11:65640906 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.46 -5.18 -0.3 4.36e-7 DNA methylation (variation); CESC cis rs3617 0.539 rs4687687 chr3:52948332 A/G cg07507251 chr3:52567010 NT5DC2 -0.31 -5.09 -0.3 6.93e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs748404 0.631 rs6493083 chr15:43637985 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.62 0.42 4.6e-13 Lung cancer; CESC cis rs7520050 0.966 rs7550746 chr1:46351719 T/A cg24296786 chr1:45957014 TESK2 0.43 5.45 0.32 1.15e-7 Red blood cell count;Reticulocyte count; CESC cis rs9287719 0.967 rs4555318 chr2:10744295 C/G cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs8070740 0.836 rs4444392 chr17:5324588 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.52 6.4 0.37 6.85e-10 Menopause (age at onset); CESC trans rs10776614 0.799 rs10857596 chr10:49764674 G/A cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs9916302 0.904 rs7223438 chr17:37521355 T/C cg07936489 chr17:37558343 FBXL20 0.78 10.74 0.55 1.4e-22 Glomerular filtration rate (creatinine); CESC cis rs4253772 0.591 rs9615343 chr22:46690824 C/G cg00784671 chr22:46762841 CELSR1 -0.58 -5.61 -0.33 4.99e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4955124 0.643 rs12629399 chr3:32039864 T/C cg05935571 chr3:32023257 ZNF860;OSBPL10 0.89 6.63 0.38 1.88e-10 Schizophrenia; CESC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg02475777 chr4:1388615 CRIPAK -0.47 -6.03 -0.35 5.48e-9 Obesity-related traits; CESC cis rs2486288 0.656 rs11637838 chr15:45550657 A/G cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.42 -0.37 6.18e-10 Glomerular filtration rate; CESC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg26314531 chr2:26401878 FAM59B -0.6 -6.82 -0.39 6.33e-11 Gut microbiome composition (summer); CESC cis rs1790761 0.505 rs2370141 chr11:67348529 A/G cg00290607 chr11:67383545 NA -0.36 -5.33 -0.31 2.14e-7 Mean corpuscular volume; CESC cis rs8072100 0.676 rs9905308 chr17:45409386 T/A cg25173405 chr17:45401733 C17orf57 -0.48 -6.27 -0.36 1.47e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25635913 chr19:4497977 HDGF2 0.45 6.03 0.35 5.48e-9 Fibrinogen levels; CESC cis rs10927875 0.632 rs6677321 chr1:16149301 A/C cg18973939 chr1:16164122 FLJ37453 0.38 5.66 0.33 3.9e-8 Dilated cardiomyopathy; CESC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -5.75 -0.33 2.43e-8 Extrinsic epigenetic age acceleration; CESC cis rs4423214 1.000 rs4944955 chr11:71167677 C/T cg24826892 chr11:71159390 DHCR7 0.44 5.08 0.3 7.05e-7 Vitamin D levels; CESC cis rs60843830 1.000 rs62114544 chr2:269679 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.78 10.02 0.52 2.91e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs3818285 0.556 rs944966 chr10:111658334 C/G cg00817464 chr10:111662876 XPNPEP1 -0.54 -7.32 -0.41 2.98e-12 Superior crus of antihelix expression; CESC cis rs1348850 0.632 rs1405718 chr2:178499809 C/T cg23306229 chr2:178417860 TTC30B 0.57 7.18 0.4 7.14e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4927850 0.752 rs7618864 chr3:195749561 G/A cg12923728 chr3:195709715 SDHAP1 -0.68 -9.17 -0.49 1.32e-17 Pancreatic cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20881074 chr2:45236659 SIX2 -0.47 -6.45 -0.37 5.18e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17253792 0.731 rs74829671 chr14:56112759 G/C cg01858014 chr14:56050164 KTN1 -0.87 -7.0 -0.39 2.15e-11 Putamen volume; CESC cis rs1670533 1.000 rs7679432 chr4:1050521 G/A cg27284194 chr4:1044797 NA 0.45 5.54 0.32 7.32e-8 Recombination rate (females); CESC cis rs2839186 0.903 rs61182475 chr21:47707050 T/A cg10351095 chr21:47802916 PCNT -0.5 -6.78 -0.38 7.81e-11 Testicular germ cell tumor; CESC cis rs11098499 0.909 rs71614422 chr4:120359340 G/A cg24375607 chr4:120327624 NA 0.46 5.78 0.33 2.1e-8 Corneal astigmatism; CESC cis rs9925964 0.748 rs11640961 chr16:30979818 C/T cg02466173 chr16:30829666 NA 0.35 5.37 0.31 1.69e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9640161 0.673 rs34489187 chr7:150044379 G/A cg13722127 chr7:150037890 RARRES2 0.38 5.08 0.3 7.09e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs9640161 0.663 rs1916932 chr7:150021644 T/C cg13722127 chr7:150037890 RARRES2 0.34 5.18 0.3 4.29e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs17764205 0.568 rs72987040 chr19:3251116 C/A cg12868887 chr11:70244470 CTTN 0.78 6.05 0.35 4.84e-9 Bipolar disorder and schizophrenia; CESC cis rs3858526 0.635 rs2045046 chr11:5875867 A/C cg05234568 chr11:5960015 NA -0.49 -5.28 -0.31 2.67e-7 DNA methylation (variation); CESC cis rs854765 0.547 rs9894138 chr17:17964345 G/A cg04398451 chr17:18023971 MYO15A 0.73 10.38 0.54 2.08e-21 Total body bone mineral density; CESC cis rs2455799 0.613 rs4467435 chr3:15791671 A/G cg16303742 chr3:15540471 COLQ -0.39 -6.14 -0.35 3.01e-9 Mean platelet volume; CESC cis rs9815354 0.716 rs73828280 chr3:41833907 A/T cg03022575 chr3:42003672 ULK4 0.54 5.32 0.31 2.26e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs11711311 1.000 rs9828099 chr3:113518402 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.74 10.44 0.54 1.33e-21 IgG glycosylation; CESC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg07153921 chr17:41440717 NA -0.4 -5.23 -0.31 3.49e-7 Menopause (age at onset); CESC trans rs7726839 0.540 rs3749618 chr5:602650 A/G cg25482853 chr8:67687455 SGK3 0.98 9.72 0.51 2.69e-19 Obesity-related traits; CESC cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg02297831 chr4:17616191 MED28 0.44 5.4 0.32 1.45e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8060686 0.641 rs73612690 chr16:68153200 G/A cg26727032 chr16:67993705 SLC12A4 -0.52 -6.29 -0.36 1.28e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.22e-18 Prudent dietary pattern; CESC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg00800038 chr16:89945340 TCF25 0.83 7.26 0.41 4.35e-12 Skin colour saturation; CESC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg19592336 chr6:28129416 ZNF389 0.54 6.94 0.39 3e-11 Parkinson's disease; CESC cis rs938554 0.779 rs13106991 chr4:9959011 G/A cg00071950 chr4:10020882 SLC2A9 -0.5 -5.59 -0.33 5.5e-8 Blood metabolite levels; CESC cis rs3892630 0.588 rs2287881 chr19:33333155 A/G cg13157960 chr19:33183277 NUDT19 -0.54 -5.66 -0.33 3.91e-8 Red blood cell traits; CESC cis rs72781680 0.898 rs72796396 chr2:24178154 G/A cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs9486719 1.000 rs12205728 chr6:96891838 T/C cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs11945232 1.000 rs28406846 chr4:88343468 C/G cg23841344 chr4:88312519 HSD17B11 -0.65 -8.19 -0.45 1.13e-14 Intelligence (multi-trait analysis); CESC trans rs7618501 0.669 rs7634084 chr3:49949834 A/T cg21659725 chr3:3221576 CRBN 0.52 7.49 0.42 1.03e-12 Intelligence (multi-trait analysis); CESC cis rs72949976 1.000 rs72949976 chr2:214034104 C/T cg08319019 chr2:214017104 IKZF2 -0.44 -5.49 -0.32 9.55e-8 Lung cancer;Squamous cell lung carcinoma; CESC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg05255149 chr17:80675120 FN3KRP 0.47 5.17 0.3 4.56e-7 Glycated hemoglobin levels; CESC cis rs3026101 0.671 rs2301740 chr17:5319620 C/A cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.22 0.31 3.64e-7 Body mass index; CESC cis rs7084402 0.905 rs1896244 chr10:60276182 A/G cg07615347 chr10:60278583 BICC1 -0.6 -9.67 -0.51 3.99e-19 Refractive error; CESC cis rs8031584 0.918 rs1425292 chr15:31285422 G/A cg08109568 chr15:31115862 NA -0.72 -9.55 -0.51 9.12e-19 Huntington's disease progression; CESC cis rs9039 0.959 rs12148920 chr16:9183900 C/G cg08831531 chr16:9218945 NA 0.4 5.96 0.34 8.09e-9 Menopause (age at onset); CESC trans rs11976180 0.569 rs12703565 chr7:143754401 C/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.67 -6.84 -0.39 5.52e-11 Obesity-related traits; CESC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg14403583 chr14:105418241 AHNAK2 -0.56 -7.82 -0.43 1.22e-13 Rheumatoid arthritis; CESC cis rs9815354 0.812 rs73071236 chr3:41992042 A/G cg03022575 chr3:42003672 ULK4 0.65 5.79 0.34 1.94e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs6867032 0.527 rs4975777 chr5:1973324 G/T cg26168224 chr5:2018326 NA -0.76 -11.03 -0.56 1.63e-23 Gut microbiome composition (winter); CESC cis rs7927592 0.913 rs67605986 chr11:68300955 C/T cg20283391 chr11:68216788 NA -0.62 -7.44 -0.42 1.42e-12 Total body bone mineral density; CESC trans rs4927850 1.000 rs7627868 chr3:195753473 A/T cg16724585 chr3:197361211 NA -0.56 -7.2 -0.4 6.32e-12 Pancreatic cancer; CESC cis rs796364 0.760 rs2202922 chr2:200882610 C/T cg23649088 chr2:200775458 C2orf69 0.6 5.44 0.32 1.23e-7 Schizophrenia; CESC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg05564831 chr3:52568323 NT5DC2 0.46 6.84 0.39 5.57e-11 Bipolar disorder; CESC cis rs1843834 0.505 rs940317 chr2:225358118 C/T cg12698349 chr2:225449008 CUL3 0.62 8.83 0.48 1.45e-16 IgE levels in asthmatics (D.p. specific); CESC cis rs10751667 0.666 rs7395823 chr11:942701 T/C cg01483505 chr11:975446 AP2A2 0.38 5.18 0.3 4.33e-7 Alzheimer's disease (late onset); CESC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg26335602 chr6:28129616 ZNF389 -0.49 -6.7 -0.38 1.21e-10 Depression; CESC cis rs1018836 0.818 rs715057 chr8:91624340 T/C cg16814680 chr8:91681699 NA -0.71 -10.75 -0.55 1.3e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg16807097 chr12:56660896 COQ10A 0.49 6.0 0.35 6.34e-9 Psoriatic arthritis; CESC cis rs921968 0.541 rs3755041 chr2:219442499 A/T cg02176678 chr2:219576539 TTLL4 -0.54 -9.75 -0.51 2.1e-19 Mean corpuscular hemoglobin concentration; CESC cis rs116095464 0.558 rs34629844 chr5:200829 A/G cg22857025 chr5:266934 NA -1.26 -14.5 -0.67 1.85e-35 Breast cancer; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg22515636 chr2:109150313 NA -0.55 -6.14 -0.35 2.93e-9 Subjective well-being; CESC cis rs76878669 0.516 rs7104570 chr11:66159098 A/G cg18002602 chr11:66138449 SLC29A2 0.44 7.33 0.41 2.73e-12 Educational attainment (years of education); CESC cis rs6032067 0.929 rs11699850 chr20:43809049 T/C cg10761708 chr20:43804764 PI3 0.52 6.27 0.36 1.45e-9 Blood protein levels; CESC cis rs4699052 0.507 rs10005997 chr4:104301711 C/G cg16532752 chr4:104119610 CENPE -0.51 -6.59 -0.38 2.33e-10 Testicular germ cell tumor; CESC cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg24110177 chr3:50126178 RBM5 0.52 7.23 0.41 5.03e-12 Intelligence (multi-trait analysis); CESC cis rs763121 1.000 rs763121 chr22:38879940 C/T cg14440974 chr22:39074834 NA 0.39 5.41 0.32 1.42e-7 Menopause (age at onset); CESC cis rs2929278 0.617 rs2955969 chr15:44114527 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.52 -6.84 -0.39 5.34e-11 Schizophrenia; CESC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg11941060 chr3:133502564 NA -0.48 -6.65 -0.38 1.67e-10 Iron status biomarkers; CESC cis rs8077889 0.703 rs231534 chr17:41945564 C/T cg26893861 chr17:41843967 DUSP3 -0.66 -6.85 -0.39 5.17e-11 Triglycerides; CESC cis rs2276314 0.857 rs3737474 chr18:33613595 T/C cg05985134 chr18:33552581 C18orf21 0.62 7.16 0.4 8.04e-12 Endometriosis;Drug-induced torsades de pointes; CESC trans rs801193 0.935 rs2659916 chr7:66151352 C/G cg26939375 chr7:64535504 NA 0.64 8.81 0.48 1.69e-16 Aortic root size; CESC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg00129232 chr17:37814104 STARD3 0.55 7.29 0.41 3.49e-12 Glomerular filtration rate (creatinine); CESC cis rs3733585 0.673 rs4580649 chr4:9948461 G/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.51 -0.32 8.39e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2455799 0.634 rs4685266 chr3:15908766 A/G cg16303742 chr3:15540471 COLQ -0.35 -5.28 -0.31 2.74e-7 Mean platelet volume; CESC cis rs7833790 0.654 rs7835342 chr8:82698092 A/G cg27398817 chr8:82754497 SNX16 -0.42 -5.32 -0.31 2.24e-7 Diastolic blood pressure; CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg07507251 chr3:52567010 NT5DC2 0.46 8.95 0.48 6.17e-17 Electroencephalogram traits; CESC cis rs7020830 0.505 rs12553878 chr9:37095705 C/T cg14294708 chr9:37120828 ZCCHC7 0.82 11.64 0.58 1.4e-25 Schizophrenia; CESC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.52e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23228694 chr20:35089521 DLGAP4 0.45 6.17 0.35 2.55e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.84 11.38 0.57 1.04e-24 Multiple sclerosis; CESC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.05 0.53 2.46e-20 Platelet count; CESC cis rs9914988 0.943 rs9902953 chr17:27139834 C/A cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs10504229 0.871 rs7002070 chr8:58153817 A/G cg02725872 chr8:58115012 NA -0.37 -5.8 -0.34 1.92e-8 Developmental language disorder (linguistic errors); CESC cis rs709400 0.663 rs11623869 chr14:103883633 G/T cg12935359 chr14:103987150 CKB -0.53 -7.87 -0.44 9e-14 Body mass index; CESC cis rs1775715 0.870 rs1755080 chr10:32255195 G/A cg04359828 chr10:32216031 ARHGAP12 0.35 5.17 0.3 4.72e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 7.52 0.42 8.32e-13 Total body bone mineral density; CESC cis rs11190604 1.000 rs10883496 chr10:102221931 T/C cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7927771 0.524 rs10838758 chr11:47771476 T/C cg18512352 chr11:47633146 NA 0.34 5.24 0.31 3.22e-7 Subjective well-being; CESC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg08027265 chr7:2291960 NA -0.34 -5.07 -0.3 7.4e-7 Bipolar disorder and schizophrenia; CESC cis rs9287719 0.967 rs13034061 chr2:10739651 C/T cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs7772486 0.686 rs4896833 chr6:145965673 T/G cg23711669 chr6:146136114 FBXO30 0.87 12.7 0.62 3.51e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg04414720 chr1:150670196 GOLPH3L 0.57 7.56 0.42 6.79e-13 Melanoma; CESC cis rs933688 1.000 rs6867219 chr5:90718008 T/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.16 14.28 0.66 1.09e-34 Smoking behavior; CESC cis rs3780486 0.846 rs7850878 chr9:33126570 A/G cg13443165 chr9:33130375 B4GALT1 0.46 6.61 0.38 2.05e-10 IgG glycosylation; CESC cis rs2115536 1.000 rs7163338 chr15:80198408 C/G cg11839771 chr15:80205821 ST20 -0.41 -5.79 -0.34 1.98e-8 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs4555082 0.957 rs3825762 chr14:105752404 T/C cg27165867 chr14:105738592 BRF1 -0.47 -5.44 -0.32 1.23e-7 Mean platelet volume;Platelet distribution width; CESC cis rs11577318 0.853 rs4450008 chr1:26643860 C/A cg00813993 chr1:26644493 UBXN11;CD52 -0.39 -6.32 -0.36 1.1e-9 Granulocyte percentage of myeloid white cells; CESC cis rs6540556 0.954 rs7536882 chr1:209936673 C/G cg23920097 chr1:209922102 NA -0.36 -5.35 -0.31 1.93e-7 Red blood cell count; CESC cis rs13130787 0.638 rs1595511 chr4:94938945 A/G cg11021082 chr4:95130006 SMARCAD1 0.42 6.05 0.35 5.05e-9 Colorectal cancer; CESC cis rs911555 0.755 rs1138400 chr14:103956833 A/G cg12935359 chr14:103987150 CKB -0.57 -8.24 -0.45 7.75e-15 Intelligence (multi-trait analysis); CESC cis rs10979 1.000 rs9390110 chr6:143893413 A/G cg25407410 chr6:143891975 LOC285740 -0.6 -9.02 -0.48 3.8e-17 Hypospadias; CESC cis rs6088580 0.634 rs6058073 chr20:33116483 T/C cg06115741 chr20:33292138 TP53INP2 0.45 5.75 0.33 2.48e-8 Glomerular filtration rate (creatinine); CESC cis rs1109430 0.661 rs12059828 chr1:210247222 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.23 0.36 1.82e-9 Orofacial clefts; CESC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg11905131 chr22:24372483 LOC391322 -0.73 -10.65 -0.55 2.71e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2742417 0.603 rs2742398 chr3:45759036 A/G cg04837898 chr3:45731254 SACM1L -0.5 -6.58 -0.37 2.44e-10 Response to anti-depressant treatment in major depressive disorder; CESC cis rs7829975 0.777 rs486781 chr8:8639740 A/G cg17143192 chr8:8559678 CLDN23 -0.47 -5.79 -0.33 2.03e-8 Mood instability; CESC cis rs5753618 0.509 rs5997913 chr22:31593959 C/A cg13145458 chr22:31556086 RNF185 0.48 5.45 0.32 1.15e-7 Colorectal cancer; CESC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg11859384 chr17:80120422 CCDC57 0.4 5.5 0.32 8.88e-8 Life satisfaction; CESC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg11247378 chr22:39784982 NA -0.64 -9.61 -0.51 5.94e-19 Intelligence (multi-trait analysis); CESC cis rs116095464 0.558 rs10462755 chr5:246748 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.37 0.31 1.73e-7 Breast cancer; CESC trans rs2488856 0.601 rs2455962 chr14:43555789 A/C cg14326805 chr9:71737756 TJP2 0.38 6.24 0.36 1.76e-9 Osteoprotegerin levels; CESC cis rs2742234 0.590 rs2505557 chr10:43666016 C/T cg07801480 chr10:43725741 RASGEF1A 0.46 5.76 0.33 2.3e-8 Hirschsprung disease; CESC cis rs78707713 0.841 rs13377102 chr10:71213386 T/A cg12610070 chr10:71211762 TSPAN15 -0.34 -5.91 -0.34 1.06e-8 Venous thromboembolism; CESC cis rs6964587 0.869 rs11769294 chr7:91549937 C/T cg17063962 chr7:91808500 NA 0.54 7.43 0.42 1.46e-12 Breast cancer; CESC cis rs728616 0.558 rs17616964 chr10:82137541 A/G cg05935833 chr10:81318306 SFTPA2 -0.46 -5.66 -0.33 3.97e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9916302 0.904 rs57399933 chr17:37551189 A/G cg00129232 chr17:37814104 STARD3 0.56 7.35 0.41 2.4e-12 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15717853 chr1:182573596 RGS16 0.57 6.71 0.38 1.15e-10 Gut microbiome composition (summer); CESC cis rs3105593 1.000 rs56080544 chr15:50950970 T/C cg08437265 chr15:50716283 USP8 0.43 5.5 0.32 8.84e-8 QT interval; CESC cis rs9905704 0.918 rs302867 chr17:56752819 C/T cg12560992 chr17:57184187 TRIM37 -0.59 -7.0 -0.39 2.11e-11 Testicular germ cell tumor; CESC cis rs6032067 0.777 rs34085254 chr20:43786170 T/G cg11264863 chr20:43835661 SEMG1 0.49 5.1 0.3 6.53e-7 Blood protein levels; CESC cis rs2832191 0.716 rs8132085 chr21:30501389 G/T cg24692254 chr21:30365293 RNF160 -0.95 -15.43 -0.69 9.31e-39 Dental caries; CESC cis rs34779708 0.931 rs11010101 chr10:35411045 T/A cg03585969 chr10:35415529 CREM 0.77 10.38 0.54 2.06e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs1568889 1.000 rs35697240 chr11:28287342 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 9.77 0.51 1.92e-19 Bipolar disorder; CESC cis rs9834373 0.811 rs9822678 chr3:78496448 C/T cg06138941 chr3:78371609 NA -0.41 -5.1 -0.3 6.42e-7 Protein quantitative trait loci; CESC cis rs4835473 0.900 rs34614750 chr4:144693522 G/T cg25736465 chr4:144833511 NA -0.33 -5.15 -0.3 5e-7 Immature fraction of reticulocytes; CESC cis rs34779708 0.931 rs4934720 chr10:35376800 T/C cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs3540 0.597 rs1978149 chr15:91036976 A/G cg10434728 chr15:90938212 IQGAP1 0.43 7.8 0.43 1.43e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs2243480 0.901 rs2900904 chr7:65204264 C/G cg12463550 chr7:65579703 CRCP 0.69 5.33 0.31 2.15e-7 Diabetic kidney disease; CESC cis rs1144333 1.000 rs76192904 chr1:76359995 C/T cg03433033 chr1:76189801 ACADM 0.55 5.46 0.32 1.08e-7 Attention function in attention deficit hyperactive disorder; CESC trans rs62103177 0.810 rs62103187 chr18:77627633 G/C cg05926928 chr17:57297772 GDPD1 1.18 10.14 0.53 1.27e-20 Opioid sensitivity; CESC cis rs9488822 0.636 rs12524932 chr6:116330266 G/A cg15226275 chr6:116381976 FRK 0.24 6.15 0.35 2.9e-9 Cholesterol, total;LDL cholesterol; CESC cis rs2072732 0.768 rs57893585 chr1:2944671 T/A cg15211996 chr1:2936768 ACTRT2 0.35 5.74 0.33 2.65e-8 Plateletcrit; CESC cis rs9303401 0.614 rs2007993 chr17:56590643 T/C cg10487724 chr17:56770010 TEX14;RAD51C 1.0 12.26 0.6 1.16e-27 Cognitive test performance; CESC cis rs9902453 1.000 rs9912741 chr17:28359511 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.11e-13 Coffee consumption (cups per day); CESC cis rs854765 0.583 rs8073001 chr17:17831716 A/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.57 -8.16 -0.45 1.37e-14 Total body bone mineral density; CESC cis rs9322193 0.962 rs2275046 chr6:150157001 A/G cg07701084 chr6:150067640 NUP43 0.44 5.89 0.34 1.14e-8 Lung cancer; CESC cis rs6693567 0.545 rs1932934 chr1:150449195 G/A cg09579323 chr1:150459698 TARS2 0.44 5.81 0.34 1.83e-8 Migraine; CESC cis rs6570726 0.846 rs411468 chr6:145832792 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs734999 0.505 rs4073285 chr1:2539796 C/T cg20673091 chr1:2541236 MMEL1 0.46 7.58 0.42 5.79e-13 Ulcerative colitis; CESC cis rs4654899 1.000 rs10916937 chr1:21439785 A/G cg05370193 chr1:21551575 ECE1 0.4 6.05 0.35 5.01e-9 Superior frontal gyrus grey matter volume; CESC cis rs1538970 0.961 rs7553318 chr1:45843086 A/G cg03146154 chr1:46216737 IPP 0.46 5.5 0.32 8.84e-8 Platelet count; CESC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 7.08 0.4 1.26e-11 Personality dimensions; CESC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg14393609 chr7:65229607 NA -0.45 -5.98 -0.34 7.2e-9 Aortic root size; CESC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg05368731 chr17:41323189 NBR1 0.77 10.72 0.55 1.6e-22 Menopause (age at onset); CESC cis rs11190604 1.000 rs2495760 chr10:102318771 T/C cg07080220 chr10:102295463 HIF1AN 0.63 5.62 0.33 4.8e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs2983496 0.901 rs79571844 chr6:166036238 T/C cg09657256 chr17:42153683 G6PC3 0.6 6.07 0.35 4.45e-9 Cortisol levels (saliva); CESC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg24060327 chr5:131705240 SLC22A5 0.74 10.31 0.53 3.65e-21 Breast cancer; CESC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg11890956 chr21:40555474 PSMG1 -0.96 -15.89 -0.7 2.07e-40 Cognitive function; CESC cis rs11190604 1.000 rs11190599 chr10:102295420 C/T cg07080220 chr10:102295463 HIF1AN 0.7 6.5 0.37 3.99e-10 Palmitoleic acid (16:1n-7) levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg17079530 chr11:117014700 PAFAH1B2 -0.48 -6.5 -0.37 3.94e-10 Asthma; CESC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg07507251 chr3:52567010 NT5DC2 0.4 6.93 0.39 3.18e-11 Bipolar disorder; CESC cis rs9309473 0.528 rs11126396 chr2:73565143 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.33 -0.36 1.06e-9 Metabolite levels; CESC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.92 0.34 9.7e-9 Tonsillectomy; CESC cis rs992157 1.000 rs13429408 chr2:219142860 C/A cg00012203 chr2:219082015 ARPC2 0.81 10.87 0.56 5.2e-23 Colorectal cancer; CESC cis rs9549260 0.755 rs9549244 chr13:41218685 C/T cg21288729 chr13:41239152 FOXO1 0.7 9.16 0.49 1.5e-17 Red blood cell count; CESC cis rs782590 0.935 rs782652 chr2:55862775 C/A cg18811423 chr2:55921094 PNPT1 0.78 12.31 0.6 7.6e-28 Metabolic syndrome; CESC cis rs6665290 0.904 rs2297415 chr1:227172903 G/A cg10327440 chr1:227177885 CDC42BPA -1.2 -28.86 -0.87 9.05e-84 Myeloid white cell count; CESC trans rs591166 0.967 rs521663 chr18:57822240 A/G cg05268347 chr19:41218064 ADCK4 -0.39 -6.2 -0.36 2.1e-9 Body mass index; CESC cis rs909674 0.775 rs8138462 chr22:39839670 G/C cg01416388 chr22:39784598 NA -0.59 -7.5 -0.42 9.7e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9329289 0.590 rs11251295 chr10:2563183 C/T cg05625103 chr10:2543513 NA 0.44 6.2 0.36 2.11e-9 Age-related hearing impairment; CESC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.06 12.34 0.6 5.85e-28 Gut microbiome composition (summer); CESC cis rs897984 0.537 rs8045637 chr16:30818662 C/T cg00531865 chr16:30841666 NA -0.58 -8.72 -0.47 3.09e-16 Dementia with Lewy bodies; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27383975 chr19:17356182 NR2F6 -0.42 -6.08 -0.35 4.11e-9 Gambling; CESC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs208520 0.874 rs208515 chr6:66945749 A/G cg07460842 chr6:66804631 NA -0.9 -10.84 -0.55 6.76e-23 Exhaled nitric oxide output; CESC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs2522056 1.000 rs2522056 chr5:131801726 C/T cg24060327 chr5:131705240 SLC22A5 0.57 6.65 0.38 1.68e-10 Lymphocyte counts;Fibrinogen; CESC cis rs643506 0.845 rs7114594 chr11:111768113 A/G cg17089665 chr11:111648010 NA -0.38 -5.51 -0.32 8.36e-8 Breast cancer; CESC cis rs926938 0.527 rs11084 chr1:115537933 A/G cg12756093 chr1:115239321 AMPD1 0.46 6.32 0.36 1.1e-9 Autism; CESC cis rs3126085 0.735 rs4845752 chr1:152226576 C/A cg03465714 chr1:152285911 FLG -0.45 -5.49 -0.32 9.55e-8 Atopic dermatitis; CESC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg21724239 chr8:58056113 NA 0.59 5.45 0.32 1.18e-7 Developmental language disorder (linguistic errors); CESC cis rs10911232 0.542 rs12128323 chr1:183050087 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 13.61 0.64 2.34e-32 Hypertriglyceridemia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25837350 chr11:61584442 FADS1 -0.46 -6.28 -0.36 1.36e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9462846 0.919 rs9471966 chr6:42891022 G/A cg05552183 chr6:42928497 GNMT 0.42 5.06 0.3 7.7e-7 Blood protein levels; CESC cis rs6439153 0.967 rs12695513 chr3:128722312 T/C cg25356066 chr3:128598488 ACAD9 0.53 6.92 0.39 3.33e-11 Pneumococcal bacteremia; CESC cis rs7824557 0.564 rs2736293 chr8:11234613 T/A cg21775007 chr8:11205619 TDH -0.54 -8.08 -0.44 2.28e-14 Retinal vascular caliber; CESC cis rs12477438 0.798 rs7570657 chr2:99654281 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.63 -8.56 -0.47 9.04e-16 Chronic sinus infection; CESC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg18252515 chr7:66147081 NA -0.66 -6.58 -0.37 2.44e-10 Diabetic kidney disease; CESC cis rs2637266 0.600 rs11001822 chr10:78325833 T/C cg18941641 chr10:78392320 NA -0.34 -5.29 -0.31 2.53e-7 Pulmonary function; CESC cis rs684232 0.583 rs2657626 chr17:603052 A/G cg15660573 chr17:549704 VPS53 -0.66 -9.29 -0.5 6.03e-18 Prostate cancer; CESC trans rs61931739 0.500 rs7310576 chr12:34474735 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.67e-12 Morning vs. evening chronotype; CESC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg03609598 chr5:56110824 MAP3K1 -0.51 -5.42 -0.32 1.36e-7 Initial pursuit acceleration; CESC trans rs3102460 0.618 rs3123697 chr1:244580348 C/T cg01977209 chr2:236293433 NA 0.48 6.15 0.35 2.8e-9 Obesity-related traits; CESC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg08859206 chr1:53392774 SCP2 0.63 9.28 0.5 6.3e-18 Monocyte count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05744073 chr17:1953268 MIR132 0.49 6.4 0.37 6.91e-10 Gut microbiota (bacterial taxa); CESC cis rs2073300 0.609 rs6137917 chr20:23360369 G/A cg12062639 chr20:23401060 NAPB 1.08 8.67 0.47 4.32e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg15556689 chr8:8085844 FLJ10661 0.51 6.27 0.36 1.45e-9 Neuroticism; CESC cis rs734999 0.505 rs10797438 chr1:2540262 C/T cg18854424 chr1:2615690 NA 0.31 6.24 0.36 1.72e-9 Ulcerative colitis; CESC trans rs9467711 0.606 rs9358936 chr6:26370657 A/G cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC cis rs2250402 0.510 rs8031319 chr15:40323692 A/G cg20255370 chr15:40268687 EIF2AK4 -0.6 -5.16 -0.3 4.91e-7 Corneal curvature; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10415122 chr15:75981489 CSPG4 -0.42 -6.12 -0.35 3.38e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg16325326 chr1:53192061 ZYG11B 0.83 12.86 0.62 9.57e-30 Monocyte count; CESC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg08470875 chr2:26401718 FAM59B -0.77 -8.44 -0.46 2.16e-15 Gut microbiome composition (summer); CESC cis rs11828289 0.660 rs75816907 chr11:23175126 G/A cg20040320 chr11:23191996 NA -0.68 -5.88 -0.34 1.25e-8 Cancer; CESC cis rs7666738 0.830 rs1869082 chr4:98841254 T/A cg05340658 chr4:99064831 C4orf37 0.71 10.18 0.53 9.12e-21 Colonoscopy-negative controls vs population controls; CESC cis rs1209950 0.512 rs374575 chr21:40193914 C/T cg02119577 chr21:40195074 ETS2 -0.43 -5.21 -0.3 3.8e-7 Non-small cell lung cancer (survival); CESC cis rs77216612 0.877 rs66561220 chr12:12878765 T/C cg04607235 chr12:12878440 APOLD1 -1.05 -16.39 -0.71 3.48e-42 Lymphocyte counts; CESC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg23048001 chr7:2026167 MAD1L1 0.45 5.94 0.34 8.72e-9 Schizophrenia; CESC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg04944784 chr2:26401820 FAM59B -0.94 -10.74 -0.55 1.46e-22 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04238871 chr10:126431886 FAM53B 0.49 6.79 0.38 7.54e-11 Gut microbiota (bacterial taxa); CESC cis rs6460942 1.000 rs112996286 chr7:12315741 G/C cg06484146 chr7:12443880 VWDE -0.81 -8.78 -0.47 2.13e-16 Coronary artery disease; CESC cis rs2637266 0.703 rs846624 chr10:78541381 G/A cg18941641 chr10:78392320 NA 0.4 7.55 0.42 6.94e-13 Pulmonary function; CESC cis rs17826219 0.568 rs9898097 chr17:29072672 T/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Body mass index; CESC cis rs55788414 0.932 rs35326835 chr16:81190413 T/C cg06400318 chr16:81190750 PKD1L2 -0.65 -6.98 -0.39 2.39e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs2997447 0.669 rs61776624 chr1:26474580 A/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.63 5.44 0.32 1.2e-7 QRS complex (12-leadsum); CESC cis rs7726839 0.507 rs111707179 chr5:593308 T/A cg16447950 chr5:562315 NA -0.6 -6.04 -0.35 5.18e-9 Obesity-related traits; CESC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.69 5.7 0.33 3.17e-8 Platelet count; CESC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg07424592 chr7:64974309 NA 0.35 5.15 0.3 5.03e-7 Calcium levels; CESC cis rs7432375 0.610 rs28458819 chr3:136522314 A/G cg15507776 chr3:136538369 TMEM22 0.61 7.9 0.44 7.59e-14 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs11690935 0.921 rs908670 chr2:172690180 T/C cg13550731 chr2:172543902 DYNC1I2 -0.95 -14.38 -0.66 4.76e-35 Schizophrenia; CESC cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg05552183 chr6:42928497 GNMT -0.55 -6.23 -0.36 1.78e-9 Blood protein levels; CESC cis rs4654899 1.000 rs6697555 chr1:21287938 C/T cg05370193 chr1:21551575 ECE1 0.36 5.35 0.31 1.89e-7 Superior frontal gyrus grey matter volume; CESC cis rs6121246 0.567 rs6060261 chr20:30192948 C/G cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs7659604 1.000 rs28532673 chr4:122664323 A/G cg19748678 chr4:122722346 EXOSC9 -0.43 -5.2 -0.3 4.07e-7 Type 2 diabetes; CESC cis rs997295 0.554 rs7180312 chr15:68105256 G/A cg08079166 chr15:68083412 MAP2K5 0.4 6.38 0.37 7.7e-10 Motion sickness; CESC cis rs1707322 1.000 rs4660335 chr1:46474718 C/T cg06784218 chr1:46089804 CCDC17 0.36 6.13 0.35 3.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4660261 0.526 rs2485996 chr1:44354661 C/T cg12908607 chr1:44402522 ARTN -0.48 -6.97 -0.39 2.54e-11 Intelligence (multi-trait analysis); CESC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg26039829 chr8:22132926 PIWIL2 0.36 5.49 0.32 9.37e-8 Hypertriglyceridemia; CESC cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.39 0.31 1.54e-7 Personality dimensions; CESC cis rs10089 0.953 rs4835940 chr5:127406596 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.77 10.17 0.53 9.95e-21 Ileal carcinoids; CESC cis rs1348850 0.561 rs1838890 chr2:178410938 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.67 6.09 0.35 3.87e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs12476592 0.602 rs7563623 chr2:63720210 A/G cg17519650 chr2:63277830 OTX1 -0.47 -5.4 -0.31 1.46e-7 Childhood ear infection; CESC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.15e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6754311 0.731 rs309168 chr2:136670298 C/T cg07169764 chr2:136633963 MCM6 0.68 8.49 0.46 1.51e-15 Mosquito bite size; CESC cis rs6456156 0.586 rs12529876 chr6:167461501 G/A cg07741184 chr6:167504864 NA 0.35 6.08 0.35 4.1e-9 Primary biliary cholangitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24249734 chr3:127872125 EEFSEC -0.46 -6.46 -0.37 4.91e-10 Gambling; CESC cis rs1784581 0.532 rs7767219 chr6:162423088 T/C cg17173639 chr6:162384350 PARK2 0.56 8.63 0.47 5.61e-16 Itch intensity from mosquito bite; CESC cis rs75477785 1.000 rs3753517 chr1:209978098 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.88 5.74 0.33 2.62e-8 Cleft lip with or without cleft palate; CESC cis rs9581857 0.685 rs9319367 chr13:28042197 T/C cg01674679 chr13:27998804 GTF3A -0.69 -5.52 -0.32 8.1e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg27535305 chr1:53392650 SCP2 0.32 5.65 0.33 4.2e-8 Monocyte count; CESC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.34 0.63 2.04e-31 Prudent dietary pattern; CESC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg22920501 chr2:26401640 FAM59B 0.91 10.38 0.54 2.08e-21 Gut microbiome composition (summer); CESC cis rs3820928 0.839 rs4673174 chr2:227801316 A/T cg11843606 chr2:227700838 RHBDD1 -0.43 -5.79 -0.33 2.02e-8 Pulmonary function; CESC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg15145296 chr3:125709740 NA -0.56 -5.97 -0.34 7.52e-9 Blood pressure (smoking interaction); CESC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.6 0.64 2.58e-32 Prudent dietary pattern; CESC cis rs300703 0.810 rs72772835 chr2:134554 C/T cg21211680 chr2:198530 NA -0.86 -6.1 -0.35 3.76e-9 Blood protein levels; CESC cis rs258892 0.895 rs155426 chr5:72117128 G/T cg21869765 chr5:72125136 TNPO1 -0.44 -5.45 -0.32 1.16e-7 Small cell lung carcinoma; CESC cis rs524023 0.874 rs495130 chr11:64449307 C/T cg19131476 chr11:64387923 NRXN2 -0.33 -5.05 -0.3 8.04e-7 Urate levels in obese individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19892525 chr11:108157498 ATM -0.67 -7.38 -0.41 2.1e-12 Gut microbiome composition (summer); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg13981034 chr14:21860709 SNORD9;CHD8 -0.46 -6.22 -0.36 1.9e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7267979 1.000 rs6132835 chr20:25434667 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.87 17.99 0.74 7.78e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.81 -0.34 1.82e-8 Lung cancer; CESC cis rs6582630 0.539 rs4882324 chr12:38499180 T/C cg26384229 chr12:38710491 ALG10B -0.42 -5.57 -0.32 6.38e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg15147215 chr3:52552868 STAB1 -0.37 -6.79 -0.39 7.28e-11 Electroencephalogram traits; CESC cis rs25645 0.792 rs8077456 chr17:38128765 C/G cg17467752 chr17:38218738 THRA -0.4 -5.26 -0.31 3.01e-7 Myeloid white cell count; CESC cis rs66530629 0.917 rs6665083 chr1:25148291 G/T cg22509179 chr1:25234806 RUNX3 -0.42 -5.38 -0.31 1.63e-7 Plateletcrit; CESC cis rs1559088 0.948 rs6510346 chr19:33598526 T/A cg17764715 chr19:33622953 WDR88 0.49 6.5 0.37 4.04e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.22e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 1.000 rs2482941 chr20:25361216 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -15.92 -0.7 1.72e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs28830936 0.510 rs11858843 chr15:42092915 C/A cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.33 -5.21 -0.3 3.77e-7 Diastolic blood pressure; CESC cis rs7927592 0.956 rs7106259 chr11:68298512 T/G cg20283391 chr11:68216788 NA -0.49 -5.88 -0.34 1.22e-8 Total body bone mineral density; CESC cis rs738322 1.000 rs4381 chr22:38570791 T/C cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10522587 chr1:120166026 ZNF697 -0.58 -6.39 -0.37 7.49e-10 Gut microbiome composition (summer); CESC cis rs938554 0.513 rs1014290 chr4:10001861 G/A cg11266682 chr4:10021025 SLC2A9 0.44 6.59 0.38 2.4e-10 Blood metabolite levels; CESC cis rs2832191 0.692 rs2254872 chr21:30414724 C/T cg08807101 chr21:30365312 RNF160 0.96 14.99 0.68 3.24e-37 Dental caries; CESC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg06221963 chr1:154839813 KCNN3 -0.67 -11.27 -0.57 2.54e-24 Prostate cancer; CESC cis rs796364 0.806 rs203767 chr2:200902411 G/A cg23649088 chr2:200775458 C2orf69 -0.56 -5.08 -0.3 7.29e-7 Schizophrenia; CESC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 10.34 0.54 2.75e-21 Platelet count; CESC cis rs10465746 0.725 rs4907188 chr1:84361608 C/T cg10977910 chr1:84465055 TTLL7 0.56 7.78 0.43 1.63e-13 Obesity-related traits; CESC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.23 0.53 6.6e-21 Prudent dietary pattern; CESC cis rs7084402 0.967 rs1614258 chr10:60308407 C/T cg07615347 chr10:60278583 BICC1 0.59 9.34 0.5 4.23e-18 Refractive error; CESC cis rs12497850 0.931 rs4974085 chr3:48924900 C/T cg06641503 chr3:48959341 ARIH2 -0.33 -5.2 -0.3 3.97e-7 Parkinson's disease; CESC cis rs8114671 0.562 rs6088636 chr20:33469746 C/T cg06115741 chr20:33292138 TP53INP2 0.45 5.48 0.32 9.68e-8 Height; CESC cis rs9359856 0.564 rs3818133 chr6:90374456 A/G cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.7 -0.33 3.12e-8 Bipolar disorder; CESC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg16647868 chr5:131706066 SLC22A5 0.4 5.3 0.31 2.44e-7 Blood metabolite levels; CESC cis rs12142240 0.667 rs45524035 chr1:46862780 C/T cg00530320 chr1:46809349 NSUN4 0.6 8.27 0.45 6.54e-15 Menopause (age at onset); CESC cis rs780094 0.606 rs6729709 chr2:27583156 G/A cg21248554 chr2:27665150 KRTCAP3 -0.26 -5.34 -0.31 1.97e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs2637266 0.745 rs2579732 chr10:78442778 T/C cg18941641 chr10:78392320 NA 0.43 7.9 0.44 7.62e-14 Pulmonary function; CESC cis rs9915657 0.870 rs4140902 chr17:70133750 A/G cg06234051 chr17:70120541 SOX9 -0.44 -6.49 -0.37 4.2e-10 Thyroid hormone levels; CESC cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg07697082 chr8:82753677 SNX16 -0.37 -5.84 -0.34 1.48e-8 Diastolic blood pressure; CESC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg27170947 chr2:26402098 FAM59B -0.57 -6.75 -0.38 9.46e-11 Gut microbiome composition (summer); CESC cis rs2439831 0.681 rs2444036 chr15:43694108 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.8 11.56 0.58 2.63e-25 Lung cancer in ever smokers; CESC cis rs7631605 0.905 rs58129217 chr3:37011624 G/A cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.22 -0.31 3.63e-7 Cerebrospinal P-tau181p levels; CESC cis rs765787 0.530 rs28396110 chr15:45536909 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs6736093 1.000 rs11673729 chr2:112665961 T/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.35 -0.31 1.91e-7 Coronary artery disease; CESC cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg10845886 chr2:3471009 TTC15 -0.58 -8.01 -0.44 3.57e-14 Neurofibrillary tangles; CESC cis rs3820068 0.581 rs67806552 chr1:15927138 T/C cg17385448 chr1:15911702 AGMAT 0.44 7.16 0.4 7.97e-12 Systolic blood pressure; CESC cis rs7605827 0.897 rs13022830 chr2:15696542 T/C cg19274914 chr2:15703543 NA 0.3 5.34 0.31 2.03e-7 Educational attainment (years of education); CESC cis rs34779708 0.897 rs9665538 chr10:35461038 T/C cg03585969 chr10:35415529 CREM 0.75 10.2 0.53 8e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs7116495 0.609 rs10736783 chr11:71654143 G/A cg26138937 chr11:71823887 C11orf51 -1.23 -8.41 -0.46 2.56e-15 Severe influenza A (H1N1) infection; CESC cis rs6088580 0.668 rs1205337 chr20:32926041 T/A cg24642439 chr20:33292090 TP53INP2 -0.52 -6.74 -0.38 9.67e-11 Glomerular filtration rate (creatinine); CESC cis rs763121 0.853 rs3788544 chr22:39064966 C/T cg14440974 chr22:39074834 NA -0.42 -5.7 -0.33 3.21e-8 Menopause (age at onset); CESC cis rs2243480 1.000 rs60683927 chr7:65394768 T/C cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC cis rs76878669 0.561 rs905770 chr11:66156765 A/G cg18002602 chr11:66138449 SLC29A2 0.42 7.05 0.4 1.51e-11 Educational attainment (years of education); CESC cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg08999081 chr20:33150536 PIGU 0.66 10.77 0.55 1.17e-22 Coronary artery disease; CESC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC cis rs5167 0.586 rs4803774 chr19:45450872 A/G cg13119609 chr19:45449297 APOC2 0.51 8.12 0.45 1.76e-14 Blood protein levels; CESC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Tonsillectomy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15727783 chr10:105727545 SLK -0.39 -6.11 -0.35 3.61e-9 Gambling; CESC cis rs875971 0.651 rs313829 chr7:65552497 A/G cg11764359 chr7:65958608 NA -0.88 -11.65 -0.58 1.33e-25 Aortic root size; CESC cis rs826838 0.967 rs10875979 chr12:39095149 G/A cg26384229 chr12:38710491 ALG10B 0.67 11.07 0.56 1.19e-23 Heart rate; CESC cis rs2832191 0.740 rs2832175 chr21:30475606 A/G cg24692254 chr21:30365293 RNF160 -0.98 -17.11 -0.72 9.72e-45 Dental caries; CESC cis rs73206853 0.563 rs80044246 chr12:111133535 C/A cg12870014 chr12:110450643 ANKRD13A 0.72 6.19 0.36 2.27e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs10751667 0.643 rs7396046 chr11:937176 T/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.44 -0.32 1.23e-7 Alzheimer's disease (late onset); CESC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg12667521 chr19:29218732 NA 0.4 5.65 0.33 4.03e-8 Methadone dose in opioid dependence; CESC cis rs9488822 0.676 rs13194714 chr6:116394819 T/A cg05304507 chr6:116381966 FRK 0.26 6.72 0.38 1.13e-10 Cholesterol, total;LDL cholesterol; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg22768615 chr10:131567747 NA -0.48 -6.28 -0.36 1.39e-9 Systemic lupus erythematosus; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg00549575 chr11:8008752 EIF3F 0.45 6.16 0.35 2.75e-9 Positive affect; CESC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg02071572 chr4:1403502 NA 0.38 5.53 0.32 7.8e-8 Longevity; CESC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.37 -0.36 8.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9435341 0.965 rs55909997 chr1:107581039 G/A cg09367891 chr1:107599246 PRMT6 0.7 8.3 0.45 5.32e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg17376030 chr22:41985996 PMM1 0.67 7.28 0.41 3.74e-12 Vitiligo; CESC cis rs854765 0.693 rs11657074 chr17:17770355 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.49 -6.88 -0.39 4.22e-11 Total body bone mineral density; CESC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg04282206 chr17:62833786 PLEKHM1P 0.54 6.22 0.36 1.95e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11677416 1.000 rs11677416 chr2:113529240 A/G cg27083787 chr2:113543245 IL1A 0.54 6.88 0.39 4.33e-11 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs12291225 0.679 rs11238 chr11:14288128 A/C cg19336497 chr11:14380999 RRAS2 0.38 5.54 0.32 7.2e-8 Sense of smell; CESC trans rs61931739 0.534 rs2220547 chr12:34106255 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.21 0.45 9.8e-15 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27514703 chr19:50380514 AKT1S1;TBC1D17 0.62 6.75 0.38 9.36e-11 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.71 0.62 3.31e-29 Gut microbiome composition (summer); CESC cis rs11077998 0.967 rs4789786 chr17:80504352 A/G cg10255544 chr17:80519551 FOXK2 -0.51 -8.21 -0.45 9.89e-15 Reticulocyte fraction of red cells; CESC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg03188948 chr7:1209495 NA 0.53 6.2 0.36 2.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4835473 0.831 rs1579816 chr4:144787925 C/T cg25736465 chr4:144833511 NA 0.44 6.58 0.37 2.48e-10 Immature fraction of reticulocytes; CESC cis rs28489187 0.683 rs11161611 chr1:85868679 C/A cg16011679 chr1:85725395 C1orf52 -0.48 -5.7 -0.33 3.19e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12205742 chr18:68097929 NA -0.56 -6.45 -0.37 5.17e-10 Gut microbiome composition (summer); CESC cis rs1950626 0.623 rs34603287 chr14:101433831 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.69 9.23 0.49 8.76e-18 Pelvic organ prolapse (moderate/severe); CESC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg09491104 chr22:46646882 C22orf40 -0.53 -5.89 -0.34 1.18e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9640161 0.742 rs2108854 chr7:150017408 C/T cg21361702 chr7:150065534 REPIN1 -0.55 -6.51 -0.37 3.69e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs7267979 0.932 rs6138588 chr20:25487523 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.76 13.57 0.64 3.43e-32 Liver enzyme levels (alkaline phosphatase); CESC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg24829409 chr8:58192753 C8orf71 -0.67 -7.32 -0.41 3e-12 Developmental language disorder (linguistic errors); CESC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 9.59 0.51 6.65e-19 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14385985 chr10:70587144 STOX1 0.59 6.77 0.38 8.03e-11 Gut microbiome composition (summer); CESC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg04234412 chr22:24373322 LOC391322 -0.52 -7.31 -0.41 3.09e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6460942 0.597 rs7811374 chr7:12517437 T/C cg10578991 chr7:12443926 VWDE -0.48 -5.06 -0.3 7.85e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01496715 chr11:252450 PSMD13 -0.59 -6.65 -0.38 1.69e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00402069 chr5:89770788 POLR3G;MBLAC2 0.52 6.23 0.36 1.8e-9 Gut microbiome composition (summer); CESC cis rs6831352 0.840 rs29001223 chr4:100047433 C/T cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs733592 0.723 rs10875766 chr12:48593580 G/C cg04545296 chr12:48745243 ZNF641 0.29 5.05 0.3 8.3e-7 Plateletcrit; CESC cis rs12586317 0.547 rs28395170 chr14:35506988 C/T cg16230307 chr14:35515116 FAM177A1 1.08 11.39 0.57 9.94e-25 Psoriasis; CESC cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg00152838 chr16:24741724 TNRC6A 0.47 5.05 0.3 8.12e-7 Intelligence (multi-trait analysis); CESC cis rs919433 1.000 rs1560277 chr2:198187903 C/T cg03934865 chr2:198174659 NA 0.41 5.94 0.34 8.76e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09809474 chr1:1840100 NA 0.51 6.08 0.35 4.1e-9 Gut microbiome composition (summer); CESC cis rs6439153 0.933 rs810952 chr3:128685905 A/G cg25356066 chr3:128598488 ACAD9 0.52 6.7 0.38 1.25e-10 Pneumococcal bacteremia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13857382 chr1:175162153 KIAA0040 -0.42 -6.06 -0.35 4.62e-9 Gambling; CESC cis rs62005083 1.000 rs62005158 chr14:74613284 A/G cg05179529 chr14:74551516 LIN52;ALDH6A1 0.74 5.42 0.32 1.34e-7 Mean corpuscular volume; CESC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg27532560 chr4:187881888 NA -0.32 -5.03 -0.3 9.08e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs9457247 1.000 rs389946 chr6:167407268 T/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.54 -0.46 1.09e-15 Crohn's disease; CESC cis rs2540647 0.614 rs34595355 chr22:18952113 G/A cg12798833 chr22:18958832 DGCR5 0.82 7.43 0.42 1.47e-12 Blood metabolite ratios; CESC cis rs7224737 0.957 rs6503687 chr17:40295397 G/A cg20291162 chr17:40259547 DHX58 -0.4 -5.48 -0.32 9.96e-8 Fibrinogen levels; CESC cis rs524023 0.957 rs893006 chr11:64365796 C/A cg19131476 chr11:64387923 NRXN2 -0.34 -5.18 -0.3 4.38e-7 Urate levels in obese individuals; CESC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 13.19 0.63 7.09e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.87 0.34 1.28e-8 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23429981 chr6:97345948 NDUFAF4 -0.46 -6.45 -0.37 5.28e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg24549020 chr5:56110836 MAP3K1 0.65 7.36 0.41 2.38e-12 Initial pursuit acceleration; CESC trans rs966321 0.773 rs4654426 chr1:4331783 C/T cg01726854 chr17:56429881 SUPT4H1 -0.45 -6.18 -0.35 2.39e-9 Factor VII; CESC cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg11952622 chr19:58962976 ZNF324B 0.47 6.47 0.37 4.74e-10 Uric acid clearance; CESC cis rs2014572 0.967 rs10413671 chr19:57763489 G/A cg12963866 chr19:57752005 ZNF805 -0.48 -6.47 -0.37 4.61e-10 Hyperactive-impulsive symptoms; CESC cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg22467129 chr15:76604101 ETFA -0.38 -5.73 -0.33 2.75e-8 Blood metabolite levels; CESC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg07507251 chr3:52567010 NT5DC2 0.43 7.45 0.42 1.34e-12 Bipolar disorder; CESC cis rs7412746 0.611 rs7532045 chr1:150821847 G/A cg04414720 chr1:150670196 GOLPH3L 0.49 6.6 0.38 2.27e-10 Melanoma; CESC cis rs11098499 0.780 rs7680914 chr4:120563053 A/G cg09307838 chr4:120376055 NA 0.86 11.62 0.58 1.75e-25 Corneal astigmatism; CESC cis rs36051895 0.659 rs61284219 chr9:5062816 C/A cg02405213 chr9:5042618 JAK2 -0.48 -5.99 -0.35 6.93e-9 Pediatric autoimmune diseases; CESC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg19622623 chr12:86230825 RASSF9 -0.47 -5.94 -0.34 8.76e-9 Major depressive disorder; CESC cis rs6921919 0.583 rs9468355 chr6:28341877 A/G cg02339392 chr6:28234615 ZNF187 -0.36 -5.26 -0.31 3.02e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.2e-8 Lung cancer; CESC cis rs1559088 0.847 rs10416218 chr19:33599127 T/C cg27124370 chr19:33622961 WDR88 0.45 6.0 0.35 6.63e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs72945132 0.882 rs7941933 chr11:70123351 G/A cg00319359 chr11:70116639 PPFIA1 0.81 7.73 0.43 2.24e-13 Coronary artery disease; CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg18099408 chr3:52552593 STAB1 -0.45 -8.34 -0.46 4.12e-15 Electroencephalogram traits; CESC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg16545954 chr1:2118288 C1orf86 -0.32 -6.06 -0.35 4.57e-9 Height; CESC cis rs7267979 0.966 rs6050611 chr20:25414419 A/G cg08601574 chr20:25228251 PYGB 0.36 5.38 0.31 1.64e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7085104 0.700 rs7096183 chr10:104609466 T/C cg15744005 chr10:104629667 AS3MT -0.37 -5.8 -0.34 1.84e-8 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs79349575 0.783 rs1994970 chr17:47014127 C/T cg16584676 chr17:46985605 UBE2Z -0.55 -6.96 -0.39 2.63e-11 Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26695780 chr7:66021476 LOC493754 0.51 6.75 0.38 9.06e-11 Fibrinogen levels; CESC cis rs1580019 0.563 rs34319173 chr7:32585904 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.42 0.37 6.41e-10 Cognitive ability; CESC cis rs5753037 0.615 rs131279 chr22:30155251 G/C cg01021169 chr22:30184971 ASCC2 -0.44 -6.23 -0.36 1.83e-9 Type 1 diabetes; CESC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg26338869 chr17:61819248 STRADA -0.62 -7.85 -0.43 1.04e-13 Prudent dietary pattern; CESC cis rs12497850 0.864 rs4521268 chr3:49137904 G/T cg06212747 chr3:49208901 KLHDC8B 0.73 9.64 0.51 4.67e-19 Parkinson's disease; CESC cis rs818427 0.964 rs459102 chr5:112228765 C/A cg07820702 chr5:112228657 REEP5 -0.47 -6.13 -0.35 3.17e-9 Total body bone mineral density; CESC cis rs7582720 1.000 rs72926771 chr2:203801226 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs514406 0.893 rs1242315 chr1:53417181 A/G cg06600287 chr1:53387719 ECHDC2 -0.29 -5.03 -0.3 8.93e-7 Monocyte count; CESC cis rs11098499 1.000 rs11098500 chr4:120219239 T/A cg09307838 chr4:120376055 NA 0.88 11.84 0.59 2.97e-26 Corneal astigmatism; CESC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg11663144 chr21:46675770 NA -0.63 -9.84 -0.52 1.12e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg17372223 chr3:52568218 NT5DC2 0.54 8.99 0.48 4.87e-17 Electroencephalogram traits; CESC cis rs11673344 0.528 rs476194 chr19:37410733 T/C cg27390819 chr19:37464633 NA -0.34 -5.12 -0.3 5.88e-7 Obesity-related traits; CESC cis rs11252926 0.550 rs10795122 chr10:466830 C/T cg16386425 chr10:429943 DIP2C -0.5 -6.28 -0.36 1.41e-9 Psychosis in Alzheimer's disease; CESC cis rs1355223 0.902 rs12800220 chr11:34701617 A/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.45 -0.37 5.28e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25067120 chr7:126893287 GRM8 0.39 6.0 0.35 6.58e-9 Gambling; CESC cis rs2439831 0.850 rs11856795 chr15:44160582 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.6 0.33 5.26e-8 Lung cancer in ever smokers; CESC cis rs7824557 0.628 rs7820301 chr8:11228672 G/A cg21775007 chr8:11205619 TDH 0.55 8.48 0.46 1.57e-15 Retinal vascular caliber; CESC cis rs7481584 1.000 rs2239898 chr11:3024462 G/A cg25174290 chr11:3078921 CARS -0.43 -5.43 -0.32 1.27e-7 Calcium levels; CESC cis rs6866344 0.570 rs1132336 chr5:178140090 C/T cg10224037 chr5:178157518 ZNF354A 0.74 8.75 0.47 2.53e-16 Neutrophil percentage of white cells; CESC cis rs9905704 0.918 rs385793 chr17:56730593 G/A cg12560992 chr17:57184187 TRIM37 0.59 7.02 0.4 1.86e-11 Testicular germ cell tumor; CESC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg08888203 chr3:10149979 C3orf24 0.5 6.33 0.36 1.05e-9 Alzheimer's disease; CESC cis rs832540 0.519 rs6450411 chr5:56265771 A/G cg14703610 chr5:56206110 C5orf35 0.5 6.57 0.37 2.71e-10 Coronary artery disease; CESC cis rs6540559 0.673 rs1073150 chr1:210017083 G/A cg25204440 chr1:209979598 IRF6 0.53 5.27 0.31 2.8e-7 Cleft lip with or without cleft palate; CESC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.51 -5.7 -0.33 3.21e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19304507 chr22:30278992 MTMR3 0.53 6.29 0.36 1.33e-9 Gut microbiome composition (summer); CESC cis rs12995491 1.000 rs12995491 chr2:88527414 C/T cg07952391 chr2:88470173 THNSL2 0.53 8.03 0.44 3.22e-14 Response to metformin (IC50); CESC cis rs9796 0.689 rs6492983 chr15:41436049 T/G cg12426344 chr15:41135900 SPINT1 -0.24 -5.19 -0.3 4.12e-7 Menopause (age at onset); CESC cis rs12681288 0.523 rs6983944 chr8:955147 A/G cg04851639 chr8:1020857 NA -0.31 -6.26 -0.36 1.55e-9 Schizophrenia; CESC cis rs4466137 0.645 rs6894022 chr5:82982945 T/C cg16102102 chr5:83017553 HAPLN1 -0.39 -6.01 -0.35 6.1e-9 Prostate cancer; CESC cis rs728616 0.681 rs56184245 chr10:82018556 C/T cg05935833 chr10:81318306 SFTPA2 -0.44 -5.74 -0.33 2.55e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2456568 0.803 rs10831140 chr11:93640689 G/A cg26875233 chr11:93583750 C11orf90 -0.3 -5.19 -0.3 4.16e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs8141529 0.871 rs5762877 chr22:29277555 G/A cg15103426 chr22:29168792 CCDC117 0.61 8.02 0.44 3.45e-14 Lymphocyte counts; CESC cis rs9828933 0.808 rs3733125 chr3:63981635 C/T cg16258503 chr3:63850278 ATXN7;THOC7 -0.89 -6.07 -0.35 4.49e-9 Type 2 diabetes; CESC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.7 -0.33 3.24e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.48 -0.37 4.35e-10 Bipolar disorder; CESC cis rs76917914 0.820 rs7846880 chr9:100822940 G/A cg03040243 chr9:100819229 NANS 0.51 5.84 0.34 1.5e-8 Immature fraction of reticulocytes; CESC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg04166393 chr7:2884313 GNA12 0.66 8.32 0.46 4.71e-15 Height; CESC cis rs6582630 0.519 rs11182457 chr12:38538331 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.86 0.39 4.74e-11 Drug-induced liver injury (flucloxacillin); CESC trans rs4843747 0.519 rs12599755 chr16:88107006 A/G cg26811252 chr16:29126840 RRN3P2 0.7 9.83 0.52 1.19e-19 Menopause (age at onset); CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg07308232 chr7:1071921 C7orf50 -0.42 -5.96 -0.34 8.05e-9 Longevity;Endometriosis; CESC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg22800045 chr5:56110881 MAP3K1 0.53 6.88 0.39 4.39e-11 Coronary artery disease; CESC cis rs62244186 0.520 rs9311361 chr3:44796132 T/G cg15225532 chr3:44803084 KIF15;KIAA1143 0.48 6.21 0.36 2e-9 Depressive symptoms; CESC trans rs17764205 0.929 rs8101042 chr19:3254124 C/G cg19548313 chr19:1065712 HMHA1 -0.5 -6.15 -0.35 2.82e-9 Bipolar disorder and schizophrenia; CESC cis rs11997175 0.609 rs4733459 chr8:33663793 T/C ch.8.33884649F chr8:33765107 NA 0.46 5.9 0.34 1.12e-8 Body mass index; CESC cis rs2832191 0.967 rs1999321 chr21:30530233 A/C cg08807101 chr21:30365312 RNF160 0.65 8.66 0.47 4.64e-16 Dental caries; CESC cis rs9527 0.590 rs3781281 chr10:104852648 A/G cg04362960 chr10:104952993 NT5C2 -0.48 -6.07 -0.35 4.42e-9 Arsenic metabolism; CESC cis rs1355223 0.525 rs10836316 chr11:34874295 C/T cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.59 -0.38 2.37e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs367943 0.666 rs7703503 chr5:112962334 A/C cg12552261 chr5:112820674 MCC 0.44 5.66 0.33 3.85e-8 Type 2 diabetes; CESC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg18099408 chr3:52552593 STAB1 -0.3 -5.04 -0.3 8.71e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03641858 chr19:12777774 MORG1;MAN2B1 0.58 6.68 0.38 1.44e-10 Gut microbiome composition (summer); CESC cis rs9815354 1.000 rs6791806 chr3:41889995 C/T cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.48e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs6088590 1.000 rs6119512 chr20:33306904 T/C cg06115741 chr20:33292138 TP53INP2 0.6 7.34 0.41 2.7e-12 Coronary artery disease; CESC cis rs9811920 0.715 rs6810262 chr3:99906342 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.37 5.68 0.33 3.47e-8 Axial length; CESC cis rs7520050 0.966 rs11589562 chr1:46466721 C/T cg24296786 chr1:45957014 TESK2 -0.46 -5.96 -0.34 7.89e-9 Red blood cell count;Reticulocyte count; CESC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg26939375 chr7:64535504 NA -0.76 -10.82 -0.55 7.64e-23 Calcium levels; CESC cis rs11112613 0.713 rs11112589 chr12:105951226 C/G cg03607813 chr12:105948248 NA -0.6 -7.49 -0.42 1.02e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs5769765 0.908 rs9627788 chr22:50300438 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.46 -5.33 -0.31 2.15e-7 Schizophrenia; CESC cis rs6987853 0.749 rs2974367 chr8:42431194 G/C cg09913449 chr8:42400586 C8orf40 0.44 7.44 0.42 1.43e-12 Mean corpuscular hemoglobin concentration; CESC cis rs8062405 0.895 rs56186137 chr16:28825953 A/G cg08761264 chr16:28874980 SH2B1 -0.45 -5.7 -0.33 3.19e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg10691866 chr7:65817282 TPST1 0.31 5.24 0.31 3.28e-7 Aortic root size; CESC cis rs950169 1.000 rs79318564 chr15:84786150 G/A cg17507749 chr15:85114479 UBE2QP1 0.61 6.66 0.38 1.56e-10 Schizophrenia; CESC cis rs4604732 0.536 rs4433437 chr1:247636580 A/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.42 5.38 0.31 1.64e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11696501 0.688 rs6130894 chr20:44322673 G/A cg11783356 chr20:44313418 WFDC10B -0.31 -5.08 -0.3 7.02e-7 Brain structure; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12996903 chr3:50275575 GNAI2 -0.47 -6.0 -0.35 6.62e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4523957 0.890 rs216217 chr17:2145090 G/A cg16513277 chr17:2031491 SMG6 0.6 8.16 0.45 1.34e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9300255 0.602 rs1626899 chr12:123708063 A/G cg00376283 chr12:123451042 ABCB9 0.7 8.89 0.48 9.66e-17 Neutrophil percentage of white cells; CESC cis rs7084402 0.967 rs1658486 chr10:60288081 A/T cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg17372223 chr3:52568218 NT5DC2 0.44 6.62 0.38 2.04e-10 Bipolar disorder; CESC cis rs727505 1.000 rs988699 chr7:124409814 C/T cg23710748 chr7:124431027 NA -0.47 -7.44 -0.42 1.43e-12 Lewy body disease; CESC cis rs9611565 0.649 rs139559 chr22:42191636 A/G cg06481639 chr22:41940642 POLR3H -0.48 -5.49 -0.32 9.59e-8 Vitiligo; CESC cis rs7208859 0.623 rs9906957 chr17:29157755 C/T cg19761014 chr17:28927070 LRRC37B2 0.74 6.11 0.35 3.61e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg24829409 chr8:58192753 C8orf71 -0.66 -7.93 -0.44 6.14e-14 Developmental language disorder (linguistic errors); CESC cis rs12142240 0.698 rs6703669 chr1:46862555 C/T cg00530320 chr1:46809349 NSUN4 0.6 8.27 0.45 6.54e-15 Menopause (age at onset); CESC cis rs9911578 0.967 rs8072712 chr17:57162464 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.09 0.3 6.85e-7 Intelligence (multi-trait analysis); CESC cis rs3126085 0.734 rs3120653 chr1:152284854 A/G cg03465714 chr1:152285911 FLG 0.42 5.21 0.3 3.83e-7 Atopic dermatitis; CESC cis rs6982240 0.569 rs6992278 chr8:142279383 C/G cg27411547 chr8:142287226 NA -0.53 -7.82 -0.43 1.26e-13 Tonsillectomy; CESC cis rs8077889 0.956 rs116979403 chr17:41849105 G/A cg26893861 chr17:41843967 DUSP3 0.85 9.78 0.51 1.75e-19 Triglycerides; CESC cis rs9287719 0.935 rs7600495 chr2:10739800 A/G cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs34891900 0.507 rs5992088 chr22:18135912 C/T cg19898043 chr22:18121309 BCL2L13 -0.53 -6.32 -0.36 1.13e-9 Sum neutrophil eosinophil counts; CESC cis rs8028182 0.636 rs4886699 chr15:75692303 A/C cg20655648 chr15:75932815 IMP3 0.47 6.01 0.35 5.98e-9 Sudden cardiac arrest; CESC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg23048001 chr7:2026167 MAD1L1 -0.4 -5.44 -0.32 1.21e-7 Bipolar disorder and schizophrenia; CESC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg23708337 chr7:1209742 NA 0.56 5.79 0.34 1.95e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7481584 0.624 rs421196 chr11:3048582 T/G cg08508325 chr11:3079039 CARS 0.29 5.08 0.3 7.06e-7 Calcium levels; CESC cis rs2742234 0.541 rs10793424 chr10:43717116 G/T cg15436174 chr10:43711423 RASGEF1A 0.47 5.58 0.32 5.81e-8 Hirschsprung disease; CESC cis rs7312774 0.618 rs7953088 chr12:107334539 G/C cg16260113 chr12:107380972 MTERFD3 0.79 7.12 0.4 9.88e-12 Severe influenza A (H1N1) infection; CESC cis rs959260 1.000 rs2891713 chr17:73386622 G/C cg12999837 chr17:73267436 MIF4GD -0.47 -5.48 -0.32 9.82e-8 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25161114 chr18:61089948 VPS4B 0.58 6.37 0.36 8.32e-10 Gut microbiome composition (summer); CESC cis rs10465746 0.780 rs2389649 chr1:84379449 C/T cg10977910 chr1:84465055 TTLL7 0.51 6.95 0.39 2.82e-11 Obesity-related traits; CESC cis rs897984 0.542 rs8061047 chr16:31068960 T/C cg02466173 chr16:30829666 NA -0.42 -7.33 -0.41 2.8e-12 Dementia with Lewy bodies; CESC cis rs10504073 0.584 rs56134839 chr8:49918899 C/T cg00325661 chr8:49890786 NA 0.55 8.31 0.45 5.1e-15 Blood metabolite ratios; CESC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg25036284 chr2:26402008 FAM59B -0.6 -6.98 -0.39 2.36e-11 Gut microbiome composition (summer); CESC cis rs6430585 0.528 rs75753154 chr2:136665711 T/C cg07169764 chr2:136633963 MCM6 1.28 19.05 0.76 1.45e-51 Corneal structure; CESC cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 -0.59 -5.2 -0.3 3.95e-7 Diabetic retinopathy; CESC cis rs2663905 0.611 rs2663924 chr15:81392903 T/G cg07050504 chr15:81391682 NA -0.4 -5.32 -0.31 2.16e-7 QT interval (drug interaction); CESC cis rs9858542 0.953 rs1987628 chr3:49399259 G/A cg07274523 chr3:49395745 GPX1 0.66 8.22 0.45 8.84e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs72627123 0.737 rs61475846 chr14:74485781 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.65 0.33 4.06e-8 Morning vs. evening chronotype; CESC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.32 -0.31 2.21e-7 Total body bone mineral density; CESC cis rs3741404 0.574 rs638227 chr11:63871549 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 9.9 0.52 7.1e-20 Platelet count; CESC cis rs7662987 0.517 rs1154406 chr4:100008494 T/C cg12011299 chr4:100065546 ADH4 0.59 6.45 0.37 5.25e-10 Smoking initiation; CESC cis rs10766533 1.000 rs10766533 chr11:19224677 A/T cg14704941 chr11:19224659 CSRP3 0.34 5.84 0.34 1.5e-8 Mean corpuscular volume;Mean corpuscular hemoglobin;Red blood cell count; CESC cis rs804280 0.662 rs11250164 chr8:11610686 C/T cg26752888 chr8:11627280 NEIL2 0.58 5.7 0.33 3.12e-8 Myopia (pathological); CESC cis rs2625529 0.617 rs62023343 chr15:72174963 C/A cg16672083 chr15:72433130 SENP8 0.42 6.4 0.37 7.07e-10 Red blood cell count; CESC cis rs36051895 0.589 rs6476950 chr9:5218416 A/T cg02405213 chr9:5042618 JAK2 -0.57 -6.78 -0.38 8e-11 Pediatric autoimmune diseases; CESC cis rs34638657 0.872 rs2967349 chr16:82194405 G/C cg09439754 chr16:82129088 HSD17B2 -0.36 -5.25 -0.31 3.08e-7 Lung adenocarcinoma; CESC cis rs9910055 0.659 rs112114764 chr17:42201041 G/T cg13607699 chr17:42295918 UBTF -0.59 -7.74 -0.43 2.11e-13 Total body bone mineral density; CESC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg11843238 chr5:131593191 PDLIM4 0.37 5.37 0.31 1.73e-7 Breast cancer; CESC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14930269 chr3:49142045 QARS 0.36 5.1 0.3 6.61e-7 Intelligence (multi-trait analysis); CESC cis rs4820539 1.000 rs756631 chr22:23463183 A/G cg14186256 chr22:23484241 RTDR1 0.82 14.91 0.68 6.48e-37 Bone mineral density; CESC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs7851660 0.967 rs7847126 chr9:100600635 A/C cg13688889 chr9:100608707 NA -0.68 -10.61 -0.55 3.8e-22 Strep throat; CESC trans rs1814175 0.817 rs28502006 chr11:50049930 T/C cg03929089 chr4:120376271 NA -0.94 -15.72 -0.69 8.37e-40 Height; CESC cis rs9611565 0.729 rs203320 chr22:41913477 T/C cg03806693 chr22:41940476 POLR3H -0.8 -10.19 -0.53 8.67e-21 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25098497 chr12:13254403 GSG1 -0.5 -6.62 -0.38 2.04e-10 Fibrinogen levels; CESC cis rs2637266 0.514 rs11516642 chr10:78473522 G/T cg18941641 chr10:78392320 NA -0.31 -5.03 -0.3 9.14e-7 Pulmonary function; CESC cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg07636037 chr3:49044803 WDR6 0.72 11.29 0.57 2.1e-24 Menarche (age at onset); CESC cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg02574844 chr11:5959923 NA -0.43 -5.12 -0.3 5.86e-7 DNA methylation (variation); CESC cis rs57221529 0.766 rs72703064 chr5:587825 T/C cg16447950 chr5:562315 NA -0.62 -6.52 -0.37 3.51e-10 Lung disease severity in cystic fibrosis; CESC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg19077165 chr18:44547161 KATNAL2 -0.65 -9.92 -0.52 6.22e-20 Personality dimensions; CESC cis rs6500602 0.627 rs934929 chr16:4587789 A/G cg08645402 chr16:4508243 NA -0.41 -6.23 -0.36 1.79e-9 Schizophrenia; CESC cis rs3845702 0.736 rs259810 chr2:180787821 T/C cg01881094 chr2:180872142 CWC22 -1.06 -8.92 -0.48 7.99e-17 Schizophrenia; CESC cis rs4523957 0.614 rs2760736 chr17:2036653 A/G cg16513277 chr17:2031491 SMG6 -0.78 -11.57 -0.58 2.42e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs763014 0.865 rs8675 chr16:633843 A/G cg00802000 chr16:706648 WDR90 -0.39 -5.84 -0.34 1.53e-8 Height; CESC cis rs1950626 0.569 rs4143956 chr14:101434356 A/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.69 9.23 0.49 8.76e-18 Pelvic organ prolapse (moderate/severe); CESC cis rs9300255 0.602 rs1727316 chr12:123618603 C/T cg19016782 chr12:123741754 C12orf65 -0.42 -5.9 -0.34 1.08e-8 Neutrophil percentage of white cells; CESC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg18876405 chr7:65276391 NA -0.51 -7.01 -0.4 1.98e-11 Aortic root size; CESC cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg03433033 chr1:76189801 ACADM 0.71 9.8 0.52 1.5e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs12291225 0.679 rs4756786 chr11:14285900 C/A cg19336497 chr11:14380999 RRAS2 -0.39 -5.63 -0.33 4.63e-8 Sense of smell; CESC cis rs2730245 0.510 rs2788471 chr7:158649786 G/T cg01943577 chr7:158741284 NA -0.44 -5.81 -0.34 1.82e-8 Height; CESC cis rs854765 0.583 rs12603148 chr17:17865257 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 6.08 0.35 4.28e-9 Total body bone mineral density; CESC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg11764359 chr7:65958608 NA 0.71 9.39 0.5 2.85e-18 Aortic root size; CESC cis rs703842 0.616 rs10783850 chr12:58229377 T/C cg02175503 chr12:58329896 NA 0.48 5.92 0.34 9.68e-9 Multiple sclerosis; CESC cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg16743903 chr16:89593216 SPG7 -0.41 -5.26 -0.31 2.98e-7 Multiple myeloma (IgH translocation); CESC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg08470875 chr2:26401718 FAM59B -0.47 -5.24 -0.31 3.31e-7 Gut microbiome composition (summer); CESC cis rs7077164 1.000 rs1227769 chr10:71586296 C/T cg20696214 chr10:71583771 COL13A1 -0.45 -6.12 -0.35 3.28e-9 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs9300255 0.722 rs67624109 chr12:123824635 C/T cg00376283 chr12:123451042 ABCB9 -0.59 -6.25 -0.36 1.6e-9 Neutrophil percentage of white cells; CESC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg06481639 chr22:41940642 POLR3H 0.52 5.68 0.33 3.48e-8 Vitiligo; CESC cis rs5769765 0.908 rs9616211 chr22:50317676 G/A cg02269571 chr22:50332266 NA -0.57 -6.6 -0.38 2.28e-10 Schizophrenia; CESC trans rs2099077 0.867 rs1014772 chr5:102788681 C/T cg07434438 chr16:72961899 ZFHX3 -0.49 -6.68 -0.38 1.4e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1005277 0.579 rs1780145 chr10:38537070 A/G cg25427524 chr10:38739819 LOC399744 -0.7 -10.26 -0.53 5.29e-21 Extrinsic epigenetic age acceleration; CESC cis rs4919044 0.866 rs1475366 chr10:94781857 T/C cg16508068 chr10:94451736 HHEX -0.5 -5.07 -0.3 7.38e-7 Coronary artery disease; CESC cis rs763121 0.819 rs6001205 chr22:39100264 T/A cg14440974 chr22:39074834 NA -0.42 -5.68 -0.33 3.48e-8 Menopause (age at onset); CESC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg08027265 chr7:2291960 NA -0.45 -6.96 -0.39 2.71e-11 Bipolar disorder and schizophrenia; CESC cis rs3087591 0.801 rs2012535 chr17:29561391 A/T cg24425628 chr17:29625626 OMG;NF1 -0.42 -5.14 -0.3 5.39e-7 Hip circumference; CESC cis rs3092073 0.603 rs4810477 chr20:44544654 C/T cg00981651 chr20:44574847 PCIF1 0.36 5.17 0.3 4.56e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg03467027 chr4:99064603 C4orf37 0.47 5.92 0.34 9.84e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.57 0.54 4.93e-22 Height; CESC cis rs9287719 0.967 rs715246 chr2:10736355 G/A cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs9549367 0.756 rs2316463 chr13:113901406 C/T cg18105134 chr13:113819100 PROZ -0.68 -8.09 -0.44 2.23e-14 Platelet distribution width; CESC cis rs660899 0.595 rs37471 chr1:44277548 A/G cg11704212 chr1:44303111 ST3GAL3 0.39 5.17 0.3 4.6e-7 Hypertension risk in short sleep duration; CESC cis rs2758596 0.850 rs2842879 chr1:156163695 G/T cg24450063 chr1:156163899 SLC25A44 0.84 8.45 0.46 1.99e-15 Paclitaxel disposition in epithelial ovarian cancer; CESC cis rs8062405 0.964 rs78613234 chr16:28839425 T/C cg08761264 chr16:28874980 SH2B1 -0.47 -5.83 -0.34 1.64e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12126786 chr5:77656518 SCAMP1 0.55 6.47 0.37 4.81e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22795212 chr1:33938026 ZSCAN20 -0.53 -6.14 -0.35 3.08e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.55 0.64 3.96e-32 Prudent dietary pattern; CESC cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg22875332 chr1:76189707 ACADM 0.73 10.17 0.53 1.02e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs8038465 0.622 rs17185525 chr15:73885539 T/C cg15420318 chr15:73925796 NPTN 0.48 6.76 0.38 8.67e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs367943 1.000 rs348928 chr5:112815295 C/T cg12552261 chr5:112820674 MCC -0.62 -7.78 -0.43 1.58e-13 Type 2 diabetes; CESC cis rs57221529 0.766 rs4527146 chr5:555236 A/G cg16447950 chr5:562315 NA -0.68 -7.54 -0.42 7.63e-13 Lung disease severity in cystic fibrosis; CESC cis rs9715521 0.867 rs6840137 chr4:59830872 A/G cg11281224 chr4:60001000 NA -0.51 -6.68 -0.38 1.43e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs79976124 0.800 rs6918860 chr6:66637741 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.69 7.91 0.44 6.93e-14 Type 2 diabetes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18439323 chr14:23755769 HOMEZ 0.42 6.09 0.35 3.85e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11657217 1.000 rs11657217 chr17:77709339 C/G cg06901238 chr17:77706717 ENPP7 0.45 5.85 0.34 1.47e-8 Diastolic blood pressure response to hydrochlorothiazide in hypertension; CESC cis rs11608355 0.515 rs11614551 chr12:109931630 G/A cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs6831352 0.918 rs29001211 chr4:100051941 C/T cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs2200578 1.000 rs60025964 chr2:99880577 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.48 5.11 0.3 6.16e-7 IgG glycosylation; CESC cis rs8114671 0.562 rs959829 chr20:33346047 T/C cg07148914 chr20:33460835 GGT7 -0.49 -6.25 -0.36 1.62e-9 Height; CESC trans rs61931739 0.500 rs34080094 chr12:34547952 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.74 0.55 1.43e-22 Morning vs. evening chronotype; CESC cis rs9430161 0.611 rs35033941 chr1:11034382 C/T cg27631724 chr1:11040367 C1orf127 0.38 6.21 0.36 2.02e-9 Ewing sarcoma; CESC cis rs4237845 1.000 rs4237845 chr12:58302436 A/G cg00677455 chr12:58241039 CTDSP2 -0.5 -6.27 -0.36 1.44e-9 Intelligence (multi-trait analysis); CESC cis rs1797885 0.524 rs2255648 chr3:12598963 A/G cg26432171 chr3:12704882 RAF1 -0.53 -7.11 -0.4 1.09e-11 Immature fraction of reticulocytes; CESC cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6968419 0.755 rs3807982 chr7:115898885 T/C cg02561103 chr7:115862891 TES -0.41 -5.42 -0.32 1.37e-7 Intraocular pressure; CESC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg21770322 chr7:97807741 LMTK2 0.58 9.02 0.48 4.04e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg04944784 chr2:26401820 FAM59B -0.96 -10.87 -0.56 5.25e-23 Gut microbiome composition (summer); CESC cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg11366901 chr6:160182831 ACAT2 0.75 9.24 0.49 8.53e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs9914544 1.000 rs9916245 chr17:18766825 C/G cg26378065 chr17:18585709 ZNF286B 0.45 5.46 0.32 1.1e-7 Educational attainment (years of education); CESC cis rs9902453 0.904 rs7208579 chr17:28263067 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 9.16 0.49 1.49e-17 Coffee consumption (cups per day); CESC trans rs875971 0.660 rs7807944 chr7:66087195 C/G cg26939375 chr7:64535504 NA -0.64 -8.59 -0.47 7.53e-16 Aortic root size; CESC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.84 0.34 1.49e-8 Menopause (age at onset); CESC cis rs1355223 0.525 rs55796371 chr11:34872769 T/C cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.64 -0.38 1.81e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs896854 0.517 rs1011795 chr8:95951073 G/A cg09323728 chr8:95962352 TP53INP1 -0.35 -6.51 -0.37 3.77e-10 Type 2 diabetes; CESC cis rs11190604 1.000 rs2489039 chr10:102328036 T/A cg07080220 chr10:102295463 HIF1AN 0.57 5.46 0.32 1.1e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg02725872 chr8:58115012 NA -0.31 -5.24 -0.31 3.24e-7 Developmental language disorder (linguistic errors); CESC cis rs5498 0.809 rs2075742 chr19:10401607 G/C cg10604476 chr19:10403908 ICAM5 0.44 6.21 0.36 1.99e-9 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg04267008 chr7:1944627 MAD1L1 -0.72 -9.35 -0.5 3.92e-18 Bipolar disorder and schizophrenia; CESC cis rs9611565 0.546 rs2092274 chr22:42123737 A/G cg03806693 chr22:41940476 POLR3H 1.04 11.92 0.59 1.69e-26 Vitiligo; CESC trans rs1945213 0.659 rs17149979 chr11:55840862 A/G cg15704280 chr7:45808275 SEPT13 0.76 7.31 0.41 3.15e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs4805272 0.512 rs66830923 chr19:29321277 C/T cg12756686 chr19:29218302 NA 0.5 6.32 0.36 1.12e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg11366901 chr6:160182831 ACAT2 0.65 8.38 0.46 3.24e-15 Age-related macular degeneration (geographic atrophy); CESC cis rs7267979 0.565 rs3752273 chr20:25594783 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -11.82 -0.59 3.68e-26 Liver enzyme levels (alkaline phosphatase); CESC cis rs4722166 0.645 rs1404006 chr7:22795077 T/C cg05265849 chr7:22767390 IL6 0.45 6.17 0.35 2.57e-9 Lung cancer; CESC cis rs3008870 0.755 rs2815365 chr1:67499628 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 7.97 0.44 4.75e-14 Lymphocyte percentage of white cells; CESC cis rs66573146 0.572 rs67252699 chr4:6946411 A/G cg00086871 chr4:6988644 TBC1D14 1.05 6.92 0.39 3.44e-11 Granulocyte percentage of myeloid white cells; CESC cis rs798766 1.000 rs798756 chr4:1707447 T/C cg10756475 chr4:1757242 NA 0.4 5.24 0.31 3.25e-7 Bladder cancer;Urinary bladder cancer; CESC cis rs1707322 0.656 rs2991981 chr1:46057144 A/G cg06784218 chr1:46089804 CCDC17 -0.43 -7.47 -0.42 1.19e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs113835537 0.529 rs11550299 chr11:66254085 G/T cg22134325 chr11:66188745 NPAS4 0.35 5.48 0.32 1.01e-7 Airway imaging phenotypes; CESC cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg12193833 chr17:30244370 NA -0.73 -6.71 -0.38 1.14e-10 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07874155 chr5:138089656 CTNNA1 0.46 6.33 0.36 1.05e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs501120 0.525 rs1704229 chr10:44689529 G/A cg09554077 chr10:44749378 NA 0.4 5.22 0.31 3.64e-7 Coronary artery disease;Coronary heart disease; CESC cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.12 0.3 5.85e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg25036284 chr2:26402008 FAM59B 0.88 9.99 0.52 3.79e-20 Gut microbiome composition (summer); CESC cis rs1707322 0.963 rs6429581 chr1:46319096 G/A cg03146154 chr1:46216737 IPP 0.78 10.75 0.55 1.29e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1797081 1.000 rs2603807 chr10:16872797 A/G cg23933602 chr10:16859644 RSU1 1.1 23.18 0.82 1.1000000000000001e-65 Platelet distribution width; CESC cis rs7726839 0.561 rs72703050 chr5:582917 A/C cg09021430 chr5:549028 NA -0.43 -5.74 -0.33 2.6e-8 Obesity-related traits; CESC cis rs854765 0.575 rs2955357 chr17:17946401 T/C cg09796270 chr17:17721594 SREBF1 -0.38 -5.12 -0.3 5.97e-7 Total body bone mineral density; CESC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.9 0.44 7.68e-14 Prudent dietary pattern; CESC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg16325326 chr1:53192061 ZYG11B 0.93 15.59 0.69 2.59e-39 Monocyte count; CESC cis rs72781680 0.699 rs72796125 chr2:23919169 C/T cg08917208 chr2:24149416 ATAD2B 1.13 10.24 0.53 5.87e-21 Lymphocyte counts; CESC cis rs12541635 0.677 rs6999580 chr8:107018254 C/T cg10147462 chr8:107024639 NA 0.46 6.95 0.39 2.77e-11 Age of smoking initiation; CESC cis rs11958404 0.932 rs76228149 chr5:157434486 G/A cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22481606 chr17:56429567 SUPT4H1 -0.42 -6.24 -0.36 1.7e-9 Gambling; CESC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.5 0.37 3.92e-10 Bipolar disorder; CESC cis rs62283056 0.512 rs4568307 chr4:6284965 A/G cg14416269 chr4:6271139 WFS1 0.44 6.32 0.36 1.09e-9 Cisplatin-induced ototoxicity; CESC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg06873352 chr17:61820015 STRADA 0.73 12.26 0.6 1.15e-27 Prudent dietary pattern; CESC cis rs4588572 0.643 rs10063319 chr5:77758425 T/C cg11547950 chr5:77652471 NA -0.44 -5.48 -0.32 9.67e-8 Triglycerides; CESC cis rs17293817 0.958 rs12779875 chr10:1438597 A/C cg08482957 chr10:1437944 ADARB2 0.37 5.3 0.31 2.48e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.43 8.38 0.46 3.04e-15 Electroencephalogram traits; CESC cis rs6088580 0.634 rs6142153 chr20:32968747 C/G cg08999081 chr20:33150536 PIGU -0.64 -11.19 -0.57 4.76e-24 Glomerular filtration rate (creatinine); CESC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg09324608 chr17:30823087 MYO1D -0.43 -6.39 -0.37 7.46e-10 Schizophrenia; CESC cis rs71403859 0.730 rs12927768 chr16:71645263 G/A cg08717414 chr16:71523259 ZNF19 -0.76 -6.58 -0.37 2.55e-10 Post bronchodilator FEV1; CESC cis rs9908102 0.740 rs8078394 chr17:12910602 C/T cg26162695 chr17:12921313 ELAC2 0.52 5.71 0.33 3.04e-8 Schizophrenia; CESC cis rs11255291 0.668 rs719748 chr10:7731885 A/G cg26051552 chr10:7670683 ITIH5 0.4 5.71 0.33 3.05e-8 Ovarian reserve; CESC cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg21918786 chr6:109611834 NA -0.41 -6.12 -0.35 3.29e-9 Reticulocyte fraction of red cells; CESC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg24549020 chr5:56110836 MAP3K1 0.67 7.49 0.42 1.02e-12 Initial pursuit acceleration; CESC cis rs6489785 0.710 rs2393717 chr12:121220375 G/C cg02419362 chr12:121203948 SPPL3 0.36 5.75 0.33 2.46e-8 Longevity;Allergic disease (asthma, hay fever or eczema); CESC cis rs6484504 0.516 rs1999250 chr11:31287455 C/T cg14844989 chr11:31128820 NA -0.39 -5.45 -0.32 1.13e-7 Red blood cell count; CESC cis rs477692 0.870 rs512655 chr10:131424547 T/A cg05714579 chr10:131428358 MGMT 0.57 8.16 0.45 1.36e-14 Response to temozolomide; CESC cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg23711669 chr6:146136114 FBXO30 -0.95 -14.35 -0.66 5.85e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs6942756 0.876 rs2303303 chr7:129019736 G/A cg02491457 chr7:128862824 NA -0.58 -8.08 -0.44 2.33e-14 White matter hyperintensity burden; CESC cis rs9486719 1.000 rs34209750 chr6:96882215 G/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs7818688 1.000 rs10100842 chr8:96025903 A/G cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17282769 chr12:11802362 ETV6 0.6 6.87 0.39 4.54e-11 Gut microbiome composition (summer); CESC cis rs919433 0.963 rs10153881 chr2:198171098 T/C cg03934865 chr2:198174659 NA -0.41 -5.69 -0.33 3.37e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs854765 1.000 rs854765 chr17:18012730 T/C cg04398451 chr17:18023971 MYO15A 0.71 9.84 0.52 1.16e-19 Total body bone mineral density; CESC cis rs1642645 0.831 rs12042133 chr1:42499365 A/C cg16685388 chr1:42384056 HIVEP3 -0.38 -5.68 -0.33 3.55e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.17 0.4 7.6e-12 Electroencephalogram traits; CESC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg16325326 chr1:53192061 ZYG11B 0.9 15.66 0.69 1.42e-39 Monocyte count; CESC cis rs9443189 0.762 rs2748943 chr6:76435543 C/T cg01950844 chr6:76311363 SENP6 -0.68 -7.22 -0.41 5.51e-12 Prostate cancer; CESC cis rs9303401 0.614 rs3087762 chr17:56568680 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.2 0.6 1.8e-27 Cognitive test performance; CESC cis rs35110281 0.659 rs11909064 chr21:45092095 G/C cg21573476 chr21:45109991 RRP1B -0.58 -8.36 -0.46 3.59e-15 Mean corpuscular volume; CESC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg08499158 chr17:42289980 UBTF 0.54 6.89 0.39 4.06e-11 Total body bone mineral density; CESC cis rs7927592 0.956 rs55816191 chr11:68262979 G/T cg16797656 chr11:68205561 LRP5 0.41 6.17 0.35 2.54e-9 Total body bone mineral density; CESC cis rs9611565 0.592 rs5996038 chr22:41965300 T/C cg06481639 chr22:41940642 POLR3H -0.59 -6.48 -0.37 4.52e-10 Vitiligo; CESC cis rs7429990 0.965 rs319685 chr3:47931984 C/A cg11946769 chr3:48343235 NME6 0.42 5.13 0.3 5.71e-7 Educational attainment (years of education); CESC cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.56 0.37 2.8e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06459454 chr8:146033798 ZNF517 0.46 6.05 0.35 4.82e-9 Fibrinogen levels; CESC cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg18351406 chr4:77819688 ANKRD56 0.43 5.31 0.31 2.33e-7 Emphysema distribution in smoking; CESC trans rs9325144 0.647 rs12831609 chr12:39051576 C/A cg23762105 chr12:34175262 ALG10 0.46 6.01 0.35 6.13e-9 Morning vs. evening chronotype; CESC cis rs826838 0.900 rs11169301 chr12:39128497 C/A cg13010199 chr12:38710504 ALG10B 0.59 7.86 0.43 9.9e-14 Heart rate; CESC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.37 -0.54 2.25e-21 Alzheimer's disease; CESC cis rs6701037 0.566 rs1014555 chr1:175134249 C/T cg00321850 chr1:175162397 KIAA0040 0.44 6.32 0.36 1.11e-9 Alcohol dependence; CESC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg00166722 chr3:10149974 C3orf24 0.51 6.06 0.35 4.6e-9 Alzheimer's disease; CESC cis rs11822910 0.724 rs60961847 chr11:57184224 G/A cg00522883 chr11:57194120 SLC43A3 0.61 6.1 0.35 3.7e-9 Platelet distribution width; CESC cis rs921968 0.565 rs13408427 chr2:219628389 C/T cg02176678 chr2:219576539 TTLL4 -0.44 -7.59 -0.42 5.38e-13 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17036024 chr1:161359810 NA 0.67 7.32 0.41 2.9e-12 Gut microbiome composition (summer); CESC cis rs6987853 0.830 rs9643888 chr8:42352007 T/C cg09913449 chr8:42400586 C8orf40 -0.34 -5.3 -0.31 2.38e-7 Mean corpuscular hemoglobin concentration; CESC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg00684032 chr4:1343700 KIAA1530 -0.37 -5.1 -0.3 6.61e-7 Obesity-related traits; CESC cis rs2243480 1.000 rs316313 chr7:65593548 G/A cg12463550 chr7:65579703 CRCP 0.73 5.68 0.33 3.5e-8 Diabetic kidney disease; CESC cis rs2404602 0.692 rs12911174 chr15:77149943 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.63 -0.33 4.54e-8 Blood metabolite levels; CESC trans rs360798 0.532 rs1906202 chr2:62806359 A/G cg07814414 chr15:31774773 NA -0.43 -6.26 -0.36 1.55e-9 Coronary artery disease; CESC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg17376030 chr22:41985996 PMM1 0.78 8.47 0.46 1.69e-15 Vitiligo; CESC cis rs3126085 0.935 rs4845741 chr1:152183474 A/G cg26876637 chr1:152193138 HRNR 0.47 5.43 0.32 1.28e-7 Atopic dermatitis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg22033559 chr17:7143253 PHF23 -0.48 -6.51 -0.37 3.7e-10 Asthma; CESC cis rs2380220 0.606 rs7754906 chr6:95992429 C/T cg15832292 chr6:96025679 MANEA 0.58 6.58 0.37 2.52e-10 Behavioural disinhibition (generation interaction); CESC cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg03213289 chr20:61660250 NA -0.35 -5.31 -0.31 2.29e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs72829446 0.530 rs111259369 chr17:7383082 C/T cg02795151 chr17:7402630 POLR2A 0.55 5.86 0.34 1.41e-8 Androgen levels; CESC cis rs9640161 0.789 rs2159234 chr7:150020422 A/T cg10018233 chr7:150070692 REPIN1 0.45 7.08 0.4 1.3e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.53 8.0 0.44 3.89e-14 Bipolar disorder; CESC cis rs5758659 0.652 rs133358 chr22:42442539 A/T cg19513890 chr22:42538836 CYP2D7P1 -0.38 -5.65 -0.33 4.12e-8 Cognitive function; CESC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg06808227 chr14:105710500 BRF1 -0.58 -7.35 -0.41 2.43e-12 Mean platelet volume;Platelet distribution width; CESC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg00339695 chr16:24857497 SLC5A11 0.53 6.43 0.37 5.81e-10 Intelligence (multi-trait analysis); CESC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg18402987 chr7:1209562 NA 0.76 8.49 0.46 1.46e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6693567 0.565 rs7513182 chr1:150442612 A/G cg09579323 chr1:150459698 TARS2 -0.47 -5.95 -0.34 8.27e-9 Migraine; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08601628 chr8:10555466 C8orf74 -0.59 -6.56 -0.37 2.8e-10 Gut microbiome composition (summer); CESC cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg13902645 chr11:5959945 NA 0.57 6.57 0.37 2.64e-10 DNA methylation (variation); CESC cis rs67460515 0.630 rs7638370 chr3:160921793 G/T cg03342759 chr3:160939853 NMD3 -0.55 -7.46 -0.42 1.22e-12 Parkinson's disease; CESC cis rs12579753 0.879 rs11115009 chr12:82165409 G/T cg24719984 chr12:82153464 PPFIA2 0.36 5.26 0.31 2.93e-7 Resting heart rate; CESC trans rs386965 0.524 rs7196953 chr16:79649394 C/T cg27092986 chr12:7858592 NA 0.41 6.08 0.35 4.07e-9 Multiple sclerosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04791456 chr3:57505743 DNAH12 0.52 6.97 0.39 2.54e-11 Fibrinogen levels; CESC cis rs3806843 0.735 rs778596 chr5:140037272 G/A cg26395211 chr5:140044315 WDR55 0.48 6.24 0.36 1.71e-9 Depressive symptoms (multi-trait analysis); CESC cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg25517755 chr10:38738941 LOC399744 -0.46 -5.91 -0.34 1.05e-8 Extrinsic epigenetic age acceleration; CESC cis rs7940866 0.874 rs7111478 chr11:130819628 A/G cg12179176 chr11:130786555 SNX19 0.63 8.57 0.47 8.74e-16 Schizophrenia; CESC cis rs1707322 1.000 rs7527079 chr1:46413450 C/G cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs889398 0.769 rs12927052 chr16:69857043 A/G cg09409435 chr16:70099608 PDXDC2 -0.43 -5.36 -0.31 1.81e-7 Body mass index; CESC cis rs868036 1.000 rs1871307 chr15:68100623 C/T cg08079166 chr15:68083412 MAP2K5 0.43 6.75 0.38 9.54e-11 Restless legs syndrome; CESC cis rs9790314 0.905 rs7613358 chr3:160949296 T/C cg03342759 chr3:160939853 NMD3 -0.47 -6.45 -0.37 5.26e-10 Morning vs. evening chronotype; CESC cis rs6963495 0.606 rs6969426 chr7:105147150 G/A cg19920283 chr7:105172520 RINT1 0.66 6.19 0.36 2.33e-9 Bipolar disorder (body mass index interaction); CESC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg06634786 chr22:41940651 POLR3H 0.62 6.8 0.39 6.99e-11 Vitiligo; CESC cis rs3747547 0.710 rs11789061 chr9:37950230 A/G cg13774184 chr9:37916125 SHB -0.56 -5.93 -0.34 9.34e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg03060546 chr3:49711283 APEH 0.44 5.38 0.31 1.61e-7 Parkinson's disease; CESC cis rs12586317 0.547 rs10134907 chr14:35499211 A/C cg16230307 chr14:35515116 FAM177A1 0.99 10.61 0.55 3.72e-22 Psoriasis; CESC trans rs60843830 1.000 rs3791224 chr2:221981 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 7.92 0.44 6.77e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7714584 1.000 rs11748151 chr5:150226292 C/T cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs7539624 0.588 rs1892077 chr1:223895116 A/G cg10100437 chr1:223903862 CAPN2 0.41 5.1 0.3 6.45e-7 Schizophrenia; CESC cis rs6504663 1.000 rs6504661 chr17:48580126 A/T cg03168497 chr17:48586147 MYCBPAP -0.45 -5.89 -0.34 1.19e-8 Visceral fat; CESC cis rs2404602 0.735 rs2454450 chr15:76831236 G/A cg23625390 chr15:77176239 SCAPER -0.43 -5.83 -0.34 1.57e-8 Blood metabolite levels; CESC trans rs304172 0.793 rs188585 chr3:62779444 G/T cg14089474 chr19:45280184 CBLC 0.55 6.21 0.36 2.06e-9 IgG glycosylation; CESC cis rs9911578 0.967 rs9894274 chr17:56977919 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.05 0.3 8.26e-7 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13689028 chr9:135230112 SETX -0.44 -6.08 -0.35 4.27e-9 Fibrinogen levels; CESC cis rs4901869 0.966 rs9972206 chr14:59336095 A/G cg02291164 chr14:59296302 NA 0.45 7.73 0.43 2.21e-13 Panic disorder; CESC cis rs2066819 1.000 rs75265219 chr12:56640341 G/A cg26714650 chr12:56694279 CS -1.42 -10.05 -0.53 2.39e-20 Psoriasis vulgaris; CESC cis rs17209837 1.000 rs17149647 chr7:87086931 T/C cg00919237 chr7:87102261 ABCB4 -0.54 -6.2 -0.36 2.14e-9 Gallbladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27512018 chr19:11039304 YIPF2;C19orf52 0.67 8.13 0.45 1.65e-14 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.46 0.46 1.87e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg17376030 chr22:41985996 PMM1 0.76 7.95 0.44 5.38e-14 Vitiligo; CESC cis rs1499972 0.938 rs1499971 chr3:117719537 A/C cg07612923 chr3:117604196 NA -0.77 -5.71 -0.33 3.06e-8 Schizophrenia; CESC cis rs6088590 0.502 rs6059861 chr20:33068563 A/T cg06115741 chr20:33292138 TP53INP2 0.46 5.98 0.34 7.34e-9 Coronary artery disease; CESC cis rs919433 0.889 rs788001 chr2:198213720 C/T cg03934865 chr2:198174659 NA 0.44 6.47 0.37 4.71e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs3092073 0.624 rs3848714 chr20:44547176 T/C cg00981651 chr20:44574847 PCIF1 0.39 5.76 0.33 2.35e-8 Intelligence (multi-trait analysis); CESC cis rs7555523 0.887 rs10800155 chr1:165723770 A/G cg24409356 chr1:165738333 TMCO1 0.82 7.36 0.41 2.38e-12 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs1143633 0.509 rs2068777 chr2:113696126 A/G cg12858261 chr2:113808755 IL1F8 0.52 6.15 0.35 2.88e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs709400 0.832 rs10145755 chr14:104121984 C/T cg24130564 chr14:104152367 KLC1 -0.42 -5.41 -0.32 1.44e-7 Body mass index; CESC cis rs7089973 0.624 rs10885613 chr10:116589400 G/A cg03647239 chr10:116582469 FAM160B1 0.43 5.29 0.31 2.6e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7772486 0.875 rs2073287 chr6:146350264 T/C cg23711669 chr6:146136114 FBXO30 0.79 11.25 0.57 2.93e-24 Lobe attachment (rater-scored or self-reported); CESC trans rs9951602 0.573 rs78623099 chr18:76646228 G/T cg02800362 chr5:177631904 HNRNPAB 0.61 7.97 0.44 4.84e-14 Obesity-related traits; CESC cis rs1879734 0.731 rs6588486 chr1:54166777 G/A cg23596471 chr1:54105337 GLIS1 0.35 5.58 0.32 5.97e-8 Mitral valve prolapse; CESC cis rs12410462 0.681 rs6682883 chr1:227635598 G/A cg23173402 chr1:227635558 NA 0.7 6.32 0.36 1.12e-9 Major depressive disorder; CESC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC trans rs11098499 0.954 rs17009122 chr4:120362403 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.9 0.52 7.24e-20 Corneal astigmatism; CESC cis rs6922893 1.000 rs4707871 chr6:71662709 G/C cg10766373 chr6:71666121 B3GAT2 -0.34 -5.37 -0.31 1.69e-7 Obesity-related traits; CESC trans rs7246760 0.867 rs3859512 chr19:9932831 C/T cg02900749 chr2:68251473 NA -0.8 -6.75 -0.38 9.06e-11 Pursuit maintenance gain; CESC cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg15556689 chr8:8085844 FLJ10661 0.44 5.63 0.33 4.53e-8 Mood instability; CESC cis rs950027 0.572 rs12910764 chr15:45609360 T/C cg21132104 chr15:45694354 SPATA5L1 -0.59 -7.19 -0.4 6.67e-12 Response to fenofibrate (adiponectin levels); CESC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 10.66 0.55 2.5e-22 Platelet count; CESC trans rs7937682 1.000 rs4936661 chr11:111587495 G/A cg18187862 chr3:45730750 SACM1L -0.56 -6.37 -0.36 8.31e-10 Primary sclerosing cholangitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17859048 chr1:151170906 PIP5K1A -0.41 -6.12 -0.35 3.35e-9 Gambling; CESC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg27170947 chr2:26402098 FAM59B -0.63 -6.91 -0.39 3.7e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg03676636 chr4:99064102 C4orf37 0.32 5.03 0.3 9.16e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01517940 chr14:69865233 SLC39A9;ERH -0.59 -7.12 -0.4 1.02e-11 Gut microbiome composition (summer); CESC cis rs2996428 0.561 rs2275827 chr1:3746585 T/G cg13057898 chr1:3703894 LRRC47 0.35 5.21 0.3 3.84e-7 Red cell distribution width; CESC cis rs12136530 0.774 rs9651024 chr1:19768954 T/C cg01832549 chr1:19774989 CAPZB -0.46 -6.41 -0.37 6.76e-10 Lead levels in blood; CESC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg03609598 chr5:56110824 MAP3K1 -0.51 -5.41 -0.32 1.4e-7 Initial pursuit acceleration; CESC cis rs4964805 0.657 rs1866293 chr12:104186655 C/T cg02344784 chr12:104178138 NT5DC3 0.46 6.57 0.37 2.73e-10 Attention deficit hyperactivity disorder; CESC cis rs7291412 0.540 rs9627391 chr22:46447097 C/T cg05468064 chr22:46423449 NA 0.33 5.21 0.3 3.86e-7 Dupuytren's disease;Subjective well-being; CESC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg18404041 chr3:52824283 ITIH1 -0.37 -6.4 -0.37 7.08e-10 Electroencephalogram traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08083689 chr4:8442326 ACOX3 0.49 6.06 0.35 4.67e-9 Gut microbiota (bacterial taxa); CESC cis rs7259376 0.869 rs4932984 chr19:22533255 T/C cg02657401 chr19:22469223 NA -0.27 -5.33 -0.31 2.08e-7 Menopause (age at onset); CESC cis rs3015497 0.789 rs923908 chr14:51123595 C/T cg09863266 chr14:51125203 SAV1 -0.35 -5.4 -0.31 1.51e-7 Mean platelet volume; CESC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.26 0.53 5.01e-21 Prudent dietary pattern; CESC cis rs709400 0.628 rs12879085 chr14:103874420 G/A cg12935359 chr14:103987150 CKB 0.48 7.19 0.4 6.57e-12 Body mass index; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg05657792 chr17:6899758 ALOX12 -0.38 -6.3 -0.36 1.26e-9 Tonsillectomy; CESC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg02951883 chr7:2050386 MAD1L1 -0.5 -6.64 -0.38 1.73e-10 Bipolar disorder and schizophrenia; CESC cis rs6500395 1.000 rs12597569 chr16:48693342 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs60154123 0.730 rs608791 chr1:210464638 C/T cg23283495 chr1:209979779 IRF6 0.4 5.28 0.31 2.7e-7 Coronary artery disease; CESC cis rs7481584 0.646 rs434114 chr11:3050210 A/G cg08508325 chr11:3079039 CARS 0.29 5.16 0.3 4.96e-7 Calcium levels; CESC cis rs3020736 0.500 rs4147638 chr22:42487900 G/A cg12850546 chr22:42539477 CYP2D7P1 0.43 5.13 0.3 5.47e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9640161 0.702 rs11765692 chr7:150026567 C/T cg10018233 chr7:150070692 REPIN1 0.46 7.34 0.41 2.59e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs2933343 0.621 rs728838 chr3:128589013 A/G cg25356066 chr3:128598488 ACAD9 0.57 8.23 0.45 8.66e-15 IgG glycosylation; CESC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg07332563 chr6:291687 DUSP22 -0.68 -8.9 -0.48 9.08e-17 Menopause (age at onset); CESC cis rs10242455 0.867 rs2687078 chr7:99304712 C/T cg07715041 chr7:99302981 CYP3A7 -0.42 -5.37 -0.31 1.71e-7 Blood metabolite levels; CESC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.6 0.33 5.33e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg06221963 chr1:154839813 KCNN3 -0.66 -11.44 -0.58 6.67e-25 Prostate cancer; CESC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 9.59 0.51 6.99e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs12134245 0.755 rs11164928 chr1:92012678 G/A cg21854759 chr1:92012499 NA -0.45 -5.71 -0.33 3.04e-8 Breast cancer; CESC cis rs66573146 0.831 rs56320732 chr4:6974319 G/A cg00086871 chr4:6988644 TBC1D14 1.15 7.48 0.42 1.08e-12 Granulocyte percentage of myeloid white cells; CESC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg22920501 chr2:26401640 FAM59B 0.89 10.2 0.53 7.89e-21 Gut microbiome composition (summer); CESC cis rs4423214 1.000 rs2040323 chr11:71172783 A/C cg24826892 chr11:71159390 DHCR7 0.46 5.11 0.3 6.18e-7 Vitamin D levels; CESC cis rs116095464 0.558 rs6878061 chr5:223072 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.74 0.33 2.63e-8 Breast cancer; CESC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg26587870 chr6:27730563 NA -0.59 -5.19 -0.3 4.16e-7 Depression; CESC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg23758822 chr17:41437982 NA 1.03 14.75 0.67 2.37e-36 Menopause (age at onset); CESC cis rs2294693 0.945 rs9369260 chr6:41010368 C/G cg14418226 chr6:40996092 UNC5CL -0.58 -6.39 -0.37 7.4e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs2280018 0.526 rs1510148 chr16:15167379 T/A cg27102117 chr16:15229624 NA 0.54 8.13 0.45 1.7e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16145071 chr2:101727897 TBC1D8 0.47 6.77 0.38 8.16e-11 Fibrinogen levels; CESC cis rs8099014 0.731 rs4261624 chr18:56101290 T/A cg12827950 chr18:55968429 NEDD4L -0.53 -5.78 -0.33 2.09e-8 Platelet count; CESC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.13 0.4 9.62e-12 Bipolar disorder; CESC cis rs1348850 0.837 rs4243388 chr2:178284604 T/G cg23306229 chr2:178417860 TTC30B 0.65 8.41 0.46 2.59e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg12756686 chr19:29218302 NA 0.58 7.52 0.42 8.38e-13 Methadone dose in opioid dependence; CESC cis rs9814567 1.000 rs13096604 chr3:134250099 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs62344088 0.744 rs76038312 chr5:229005 A/G cg22496380 chr5:211416 CCDC127 -0.9 -5.46 -0.32 1.12e-7 Asthma (childhood onset); CESC cis rs7909074 0.898 rs10793565 chr10:45388231 G/C cg04218760 chr10:45406644 TMEM72 -0.3 -5.05 -0.3 8.19e-7 Mean corpuscular volume; CESC cis rs892961 0.932 rs7208671 chr17:75413129 T/C cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs208520 0.526 rs9363522 chr6:66816642 C/T cg07460842 chr6:66804631 NA -1.09 -26.19 -0.85 1.77e-75 Exhaled nitric oxide output; CESC trans rs60843830 0.964 rs17713568 chr2:242132 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 8.4 0.46 2.72e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs8062405 0.679 rs72793818 chr16:28893137 G/A cg08761264 chr16:28874980 SH2B1 -0.46 -5.79 -0.34 1.98e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs897984 0.762 rs12930545 chr16:30938811 A/G cg00531865 chr16:30841666 NA 0.51 7.12 0.4 1.01e-11 Dementia with Lewy bodies; CESC cis rs2439831 0.681 rs825740 chr15:43592408 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.62 0.55 3.44e-22 Lung cancer in ever smokers; CESC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg13012494 chr21:47604986 C21orf56 0.44 5.86 0.34 1.38e-8 Testicular germ cell tumor; CESC cis rs763121 0.853 rs35522482 chr22:39063015 C/A cg06544989 chr22:39130855 UNC84B 0.48 8.4 0.46 2.69e-15 Menopause (age at onset); CESC cis rs2204008 0.837 rs73112346 chr12:38357606 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.62 0.38 2.03e-10 Bladder cancer; CESC cis rs2236918 0.622 rs1776177 chr1:242012149 C/T cg17736920 chr1:242011382 EXO1 0.52 6.67 0.38 1.49e-10 Menopause (age at onset); CESC cis rs2735413 0.711 rs12921476 chr16:78079846 G/C cg04733911 chr16:78082701 NA -0.52 -8.51 -0.46 1.27e-15 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg22823121 chr1:150693482 HORMAD1 0.39 5.46 0.32 1.11e-7 Melanoma; CESC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC cis rs5753618 0.504 rs9609329 chr22:31966313 A/C cg00478049 chr22:31556069 RNF185 -0.48 -5.72 -0.33 2.91e-8 Colorectal cancer; CESC cis rs1545257 0.537 rs2339948 chr2:24641012 A/T cg06627628 chr2:24431161 ITSN2 -0.48 -5.82 -0.34 1.67e-8 Sjögren's syndrome; CESC cis rs2486288 0.656 rs8039540 chr15:45551842 C/G cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs10089 1.000 rs1559263 chr5:127512873 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.43 0.5 2.16e-18 Ileal carcinoids; CESC trans rs9329221 0.683 rs658385 chr8:9892177 C/T cg15556689 chr8:8085844 FLJ10661 -0.58 -7.59 -0.42 5.61e-13 Neuroticism; CESC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.16 -0.3 4.89e-7 Lung cancer; CESC cis rs76419734 0.510 rs17036102 chr4:106603098 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.71 -9.14 -0.49 1.71e-17 Post bronchodilator FEV1; CESC cis rs72772090 0.539 rs11739020 chr5:96113838 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.62 5.54 0.32 7.4e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9611565 0.568 rs2413656 chr22:42129357 G/T cg06481639 chr22:41940642 POLR3H 0.48 5.62 0.33 4.86e-8 Vitiligo; CESC trans rs16850073 0.689 rs9998340 chr4:74657255 A/G cg13990905 chr1:179846837 TOR1AIP2 0.44 6.19 0.36 2.28e-9 Granulocyte percentage of myeloid white cells;Blood protein levels;Monocyte percentage of white cells;Sum neutrophil eosinophil counts;White blood cell count; CESC cis rs7671266 0.628 rs11734783 chr4:10240663 C/T cg00071950 chr4:10020882 SLC2A9 0.47 5.17 0.3 4.66e-7 Cardiovascular disease risk factors; CESC cis rs4604732 0.631 rs74154676 chr1:247625894 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2276314 0.857 rs72883058 chr18:33612917 G/A cg19628046 chr18:33552617 C18orf21 0.51 5.79 0.33 2.04e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7772486 0.790 rs7753092 chr6:146248863 C/T cg05347473 chr6:146136440 FBXO30 -0.55 -7.03 -0.4 1.78e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs12579753 0.917 rs7138651 chr12:82253615 A/G cg23701643 chr12:82153290 PPFIA2 0.35 5.19 0.3 4.15e-7 Resting heart rate; CESC cis rs11723261 0.564 rs61792258 chr4:137264 G/A cg12746427 chr4:53362 ZNF718;ZNF595 0.43 5.1 0.3 6.37e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs9640161 0.789 rs34311995 chr7:150059255 T/C cg10018233 chr7:150070692 REPIN1 0.38 5.88 0.34 1.25e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs1008375 0.966 rs4698636 chr4:17632834 T/C cg16339924 chr4:17578868 LAP3 0.57 7.1 0.4 1.17e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg00339695 chr16:24857497 SLC5A11 -0.45 -5.97 -0.34 7.41e-9 Intelligence (multi-trait analysis); CESC cis rs7998202 0.667 rs282586 chr13:113351474 T/C cg02820901 chr13:113351484 ATP11A 0.67 5.77 0.33 2.17e-8 Glycated hemoglobin levels; CESC cis rs9788682 1.000 rs7164594 chr15:78803057 C/T cg06917634 chr15:78832804 PSMA4 -0.55 -6.27 -0.36 1.47e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs67311347 1.000 rs7612015 chr3:40399974 A/C cg01475735 chr3:40494733 NA -0.41 -5.27 -0.31 2.87e-7 Renal cell carcinoma; CESC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.78 0.38 7.94e-11 Bipolar disorder; CESC cis rs4919087 0.892 rs10882881 chr10:99010067 T/A cg25902810 chr10:99078978 FRAT1 0.66 9.39 0.5 2.88e-18 Monocyte count; CESC cis rs4835473 0.900 rs35906127 chr4:144655553 G/C cg25736465 chr4:144833511 NA -0.33 -5.15 -0.3 5.14e-7 Immature fraction of reticulocytes; CESC cis rs7635838 0.927 rs13082150 chr3:11437813 T/C cg00170343 chr3:11313890 ATG7 0.41 5.39 0.31 1.52e-7 HDL cholesterol; CESC cis rs12586317 0.620 rs12588810 chr14:35554484 C/T cg16230307 chr14:35515116 FAM177A1 0.94 9.93 0.52 5.75e-20 Psoriasis; CESC cis rs977987 0.843 rs10431974 chr16:75435461 A/G cg03315344 chr16:75512273 CHST6 0.4 5.67 0.33 3.74e-8 Dupuytren's disease; CESC cis rs11587400 0.614 rs2878745 chr1:115078547 T/C cg12756093 chr1:115239321 AMPD1 0.37 5.08 0.3 7.3e-7 Autism; CESC cis rs9834373 0.769 rs9856198 chr3:78496305 A/G cg06138941 chr3:78371609 NA -0.41 -5.12 -0.3 5.98e-7 Protein quantitative trait loci; CESC cis rs6752107 0.967 rs56049444 chr2:234157688 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.43 5.92 0.34 1.02e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs4835473 0.932 rs10033382 chr4:144888256 A/G cg25736465 chr4:144833511 NA 0.41 6.27 0.36 1.43e-9 Immature fraction of reticulocytes; CESC trans rs1973993 0.967 rs1555543 chr1:96944797 A/C cg10631902 chr5:14652156 NA 0.53 7.39 0.41 1.89e-12 Weight; CESC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg22143856 chr6:28129313 ZNF389 0.52 6.77 0.38 8.31e-11 Depression; CESC cis rs7827545 1.000 rs6578237 chr8:135569358 C/G cg17885191 chr8:135476712 NA -0.41 -5.76 -0.33 2.34e-8 Hypertension (SNP x SNP interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14597223 chr7:56119231 PSPH;CCT6A -0.52 -7.19 -0.4 6.62e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3760982 0.585 rs11673490 chr19:44298885 C/A cg11993925 chr19:44307056 LYPD5 0.34 5.85 0.34 1.45e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs3820068 0.608 rs11544523 chr1:15904318 C/T cg18192808 chr1:15853278 DNAJC16 0.44 5.21 0.3 3.82e-7 Systolic blood pressure; CESC cis rs6088580 0.634 rs6058051 chr20:33044862 G/A cg06115741 chr20:33292138 TP53INP2 0.47 6.08 0.35 4.22e-9 Glomerular filtration rate (creatinine); CESC cis rs2180341 1.000 rs6569479 chr6:127606588 A/G cg24812749 chr6:127587940 RNF146 1.06 15.34 0.69 1.95e-38 Breast cancer; CESC cis rs6032067 0.777 rs2868234 chr20:43794026 C/T cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg18016565 chr1:150552671 MCL1 -0.35 -5.15 -0.3 5.01e-7 Urate levels; CESC trans rs11098499 0.909 rs35165976 chr4:120325630 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs2276314 0.947 rs3898595 chr18:33565885 T/A cg05985134 chr18:33552581 C18orf21 0.64 7.43 0.42 1.5e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs9815354 0.951 rs1617271 chr3:41914000 G/T cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs8141529 0.509 rs5762863 chr22:29253335 A/C cg02153584 chr22:29168773 CCDC117 0.6 8.06 0.44 2.66e-14 Lymphocyte counts; CESC cis rs9790314 1.000 rs336543 chr3:161061080 C/T cg03342759 chr3:160939853 NMD3 0.46 6.0 0.35 6.31e-9 Morning vs. evening chronotype; CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.44 -5.84 -0.34 1.5e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11696845 0.626 rs4810439 chr20:43377870 C/G cg25301532 chr20:43378953 KCNK15 -0.35 -5.67 -0.33 3.82e-8 Obesity-related traits; CESC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg04248312 chr19:17393744 ANKLE1 -0.92 -14.85 -0.67 1.01e-36 Systemic lupus erythematosus; CESC cis rs709400 0.894 rs61996721 chr14:104061352 G/A cg12935359 chr14:103987150 CKB -0.49 -6.42 -0.37 6.23e-10 Body mass index; CESC cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg10523679 chr1:76189770 ACADM 0.76 9.99 0.52 3.63e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7660520 0.557 rs76004373 chr4:183731011 C/G cg03209412 chr4:183728196 NA 0.59 5.26 0.31 3.05e-7 Pediatric autoimmune diseases; CESC cis rs727563 0.552 rs4822045 chr22:41985958 C/A cg06634786 chr22:41940651 POLR3H -0.67 -6.46 -0.37 4.85e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs909674 0.734 rs5757675 chr22:39838892 G/T cg01416388 chr22:39784598 NA -0.59 -7.53 -0.42 8.07e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg19163074 chr7:65112434 INTS4L2 0.42 5.3 0.31 2.46e-7 Aortic root size; CESC cis rs72781680 1.000 rs12620594 chr2:24194490 G/A cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.56e-8 Lymphocyte counts; CESC cis rs478304 0.651 rs11532071 chr11:65500198 C/A cg27068330 chr11:65405492 SIPA1 -0.45 -5.46 -0.32 1.08e-7 Acne (severe); CESC trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg15704280 chr7:45808275 SEPT13 -0.86 -9.72 -0.51 2.72e-19 Coronary artery disease; CESC cis rs7116495 1.000 rs73543633 chr11:71828844 T/C cg26138937 chr11:71823887 C11orf51 0.8 6.42 0.37 6.17e-10 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14491479 chr8:144623711 ZC3H3 0.58 7.1 0.4 1.17e-11 Gut microbiome composition (summer); CESC cis rs10504073 0.584 rs7823690 chr8:49943831 G/A cg00325661 chr8:49890786 NA 0.56 8.53 0.46 1.16e-15 Blood metabolite ratios; CESC cis rs7914558 0.901 rs35525740 chr10:104941112 A/T cg15744005 chr10:104629667 AS3MT -0.31 -5.04 -0.3 8.72e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12900413 0.959 rs12908026 chr15:90318884 C/T cg24249390 chr15:90295951 MESP1 -0.41 -5.3 -0.31 2.39e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs763121 0.853 rs3761454 chr22:39066820 C/T cg06544989 chr22:39130855 UNC84B 0.49 8.54 0.46 1.06e-15 Menopause (age at onset); CESC cis rs56346965 0.506 rs2159818 chr2:191532789 A/G cg27211696 chr2:191398769 TMEM194B -0.43 -5.49 -0.32 9.55e-8 Bone mineral density (Ward's triangle area); CESC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg08859206 chr1:53392774 SCP2 -0.64 -8.54 -0.46 1.04e-15 Monocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12066592 chr14:34931026 C14orf147 -0.41 -6.1 -0.35 3.82e-9 Gambling; CESC cis rs4919087 0.810 rs1572437 chr10:99029278 A/G cg25902810 chr10:99078978 FRAT1 0.66 9.22 0.49 9.48e-18 Monocyte count; CESC cis rs9911578 1.000 rs2079703 chr17:56603978 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC cis rs6430585 0.646 rs12476116 chr2:136497199 A/G cg07169764 chr2:136633963 MCM6 1.37 16.25 0.71 1.09e-41 Corneal structure; CESC cis rs3760982 0.546 rs73048681 chr19:44289945 T/C cg11993925 chr19:44307056 LYPD5 0.47 8.09 0.44 2.19e-14 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs2243480 1.000 rs4718270 chr7:65202407 A/G cg13147721 chr7:65941812 NA -0.88 -8.11 -0.45 1.87e-14 Diabetic kidney disease; CESC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg10691866 chr7:65817282 TPST1 0.33 5.23 0.31 3.45e-7 Aortic root size; CESC cis rs7894051 1.000 rs7894051 chr10:135184421 C/G cg24905316 chr10:135186343 ECHS1 -0.68 -6.89 -0.39 4.11e-11 Lifespan; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21364231 chr7:152161058 LOC100128822 -0.47 -6.13 -0.35 3.23e-9 Fibrinogen levels; CESC cis rs12824058 0.831 rs12297939 chr12:130811923 G/C cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs67311347 1.000 rs6762997 chr3:40478151 C/T cg01475735 chr3:40494733 NA -0.41 -5.33 -0.31 2.08e-7 Renal cell carcinoma; CESC cis rs4474465 0.850 rs4945289 chr11:78245334 G/T cg27205649 chr11:78285834 NARS2 0.43 5.41 0.32 1.41e-7 Alzheimer's disease (survival time); CESC cis rs4891159 0.548 rs609487 chr18:74134382 C/G cg24786174 chr18:74118243 ZNF516 -0.82 -15.51 -0.69 4.65e-39 Longevity; CESC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg27170947 chr2:26402098 FAM59B -0.58 -6.85 -0.39 5.18e-11 Gut microbiome composition (summer); CESC cis rs4642101 0.618 rs7612317 chr3:12820558 C/T cg05775895 chr3:12838266 CAND2 0.41 6.36 0.36 8.94e-10 QRS complex (12-leadsum); CESC cis rs782590 0.557 rs7592219 chr2:55887176 T/C cg18811423 chr2:55921094 PNPT1 -0.6 -8.04 -0.44 3.03e-14 Metabolic syndrome; CESC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs11583043 0.957 rs6577223 chr1:101499750 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.52 5.57 0.32 6.2e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg02487422 chr3:49467188 NICN1 0.45 5.68 0.33 3.57e-8 Parkinson's disease; CESC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg12463550 chr7:65579703 CRCP -0.5 -6.34 -0.36 9.71e-10 Aortic root size; CESC trans rs853679 0.546 rs200948 chr6:27835272 T/C cg06606381 chr12:133084897 FBRSL1 -0.83 -7.8 -0.43 1.44e-13 Depression; CESC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg00475322 chr7:917719 C7orf20 0.59 9.15 0.49 1.52e-17 Perceived unattractiveness to mosquitoes; CESC cis rs34421088 0.564 rs6983129 chr8:11591136 A/C cg12395012 chr8:11607386 GATA4 -0.4 -6.12 -0.35 3.29e-9 Neuroticism; CESC cis rs56804039 1.000 rs6986470 chr8:8381430 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -5.28 -0.31 2.66e-7 Cervical cancer; CESC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.57e-7 Depression; CESC trans rs11039798 0.528 rs10769559 chr11:49032446 T/C cg03929089 chr4:120376271 NA 0.61 6.36 0.36 9.02e-10 Axial length; CESC cis rs9486715 0.867 rs7451950 chr6:96879974 T/C cg06623918 chr6:96969491 KIAA0776 0.91 14.05 0.65 6.83e-34 Headache; CESC cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg24642844 chr7:1081250 C7orf50 -0.44 -5.88 -0.34 1.22e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg23281280 chr6:28129359 ZNF389 0.52 6.86 0.39 4.93e-11 Parkinson's disease; CESC cis rs6912958 0.559 rs451465 chr6:88043372 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.45 -7.86 -0.43 9.48e-14 Monocyte percentage of white cells; CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg24846343 chr22:24311635 DDTL 0.62 10.38 0.54 2.11e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2070488 0.896 rs11914389 chr3:38527215 T/C cg24069376 chr3:38537580 EXOG 0.48 8.61 0.47 6.72e-16 Electrocardiographic conduction measures; CESC cis rs3096299 0.874 rs3102342 chr16:89451575 T/C cg08392591 chr16:89556376 ANKRD11 0.4 5.09 0.3 6.77e-7 Multiple myeloma (IgH translocation); CESC cis rs662064 0.963 rs636291 chr1:10556097 G/A cg07384165 chr1:10488281 NA -0.42 -5.48 -0.32 9.81e-8 Asthma; CESC cis rs6831352 0.918 rs34071486 chr4:100051087 A/G cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs919433 0.963 rs12618612 chr2:198171058 G/T cg03934865 chr2:198174659 NA -0.41 -5.46 -0.32 1.11e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.75e-12 Tonsillectomy; CESC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg03806693 chr22:41940476 POLR3H 1.18 13.88 0.65 2.76e-33 Vitiligo; CESC cis rs208520 0.674 rs207103 chr6:66795568 G/T cg07460842 chr6:66804631 NA -1.0 -13.33 -0.63 2.21e-31 Exhaled nitric oxide output; CESC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg02569458 chr12:86230093 RASSF9 -0.49 -7.4 -0.41 1.79e-12 Major depressive disorder; CESC cis rs3096299 0.967 rs11648663 chr16:89466307 C/T cg16743903 chr16:89593216 SPG7 -0.4 -5.11 -0.3 6.25e-7 Multiple myeloma (IgH translocation); CESC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg13206674 chr6:150067644 NUP43 0.43 6.27 0.36 1.44e-9 Lung cancer; CESC cis rs4727027 0.933 rs10238826 chr7:148830888 A/G cg23583168 chr7:148888333 NA -0.73 -10.82 -0.55 7.76e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg13777783 chr17:79615861 NA -0.36 -6.04 -0.35 5.09e-9 Eye color traits; CESC cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs66573146 0.808 rs73202120 chr4:7005588 A/G cg00086871 chr4:6988644 TBC1D14 0.98 7.65 0.43 3.79e-13 Granulocyte percentage of myeloid white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01413268 chr19:51602462 CTU1 -0.49 -6.6 -0.38 2.28e-10 Gut microbiome composition (summer); CESC cis rs17401966 0.838 rs2105212 chr1:10281012 T/C cg15208524 chr1:10270712 KIF1B 0.39 5.14 0.3 5.23e-7 Hepatocellular carcinoma; CESC cis rs7666738 0.830 rs7664051 chr4:98766970 C/G cg17366294 chr4:99064904 C4orf37 0.57 7.91 0.44 6.78e-14 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00776160 chr1:149815087 HIST2H2AA3;HIST2H2AA4 -0.44 -6.34 -0.36 9.62e-10 Gambling; CESC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg09359103 chr1:154839909 KCNN3 -0.65 -12.4 -0.61 3.83e-28 Prostate cancer; CESC cis rs9611565 0.500 rs2011053 chr22:42121278 G/A cg06634786 chr22:41940651 POLR3H 0.45 5.04 0.3 8.76e-7 Vitiligo; CESC cis rs7188697 0.922 rs2090727 chr16:58604161 A/G cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs3741151 0.686 rs2298469 chr11:73133030 T/C cg17517138 chr11:73019481 ARHGEF17 0.65 5.56 0.32 6.5e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.45 0.37 5.37e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18151858 chr13:21635991 LATS2 -0.53 -6.32 -0.36 1.1e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.576 rs7660951 chr4:98651581 T/A cg17366294 chr4:99064904 C4orf37 0.52 6.43 0.37 6.02e-10 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs735396 1.000 rs2464195 chr12:121435475 G/A cg02403541 chr12:121454288 C12orf43 0.63 9.13 0.49 1.82e-17 N-glycan levels; CESC cis rs25645 0.744 rs66826786 chr17:38206092 T/C cg17467752 chr17:38218738 THRA -0.53 -6.73 -0.38 1.06e-10 Myeloid white cell count; CESC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg04166393 chr7:2884313 GNA12 0.57 7.16 0.4 7.92e-12 Height; CESC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.25 0.41 4.5e-12 Height; CESC cis rs8103278 1.000 rs35302007 chr19:46219145 G/C cg12641515 chr19:46296257 DMWD -0.49 -5.63 -0.33 4.69e-8 Coronary artery disease; CESC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg00409905 chr10:38381863 ZNF37A -0.5 -6.75 -0.38 9.28e-11 Extrinsic epigenetic age acceleration; CESC cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.82e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg23131131 chr22:24373011 LOC391322 -0.66 -8.91 -0.48 8.58e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.42 6.8 0.39 7.05e-11 Hemoglobin concentration; CESC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.69 -0.51 3.35e-19 Alzheimer's disease; CESC trans rs1814175 0.587 rs7937757 chr11:49978342 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs12497850 0.931 rs3774628 chr3:48801840 C/T cg06212747 chr3:49208901 KLHDC8B 0.65 8.94 0.48 6.96e-17 Parkinson's disease; CESC cis rs8062405 0.755 rs111693583 chr16:28583610 C/T cg01378222 chr16:28622494 SULT1A1 0.32 5.34 0.31 1.98e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6963495 0.769 rs73192134 chr7:105189338 T/C cg13798780 chr7:105162888 PUS7 0.77 7.85 0.43 1.02e-13 Bipolar disorder (body mass index interaction); CESC cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs4919087 0.962 rs10786324 chr10:99054387 A/G cg25902810 chr10:99078978 FRAT1 0.71 10.4 0.54 1.79e-21 Monocyte count; CESC cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg26597838 chr10:835615 NA 0.83 8.8 0.48 1.8e-16 Eosinophil percentage of granulocytes; CESC cis rs796364 0.806 rs77853713 chr2:201006880 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -6.83 -0.39 5.71e-11 Schizophrenia; CESC cis rs4704187 0.687 rs1422696 chr5:74464415 T/C cg03227963 chr5:74354835 NA 0.29 5.2 0.3 3.9e-7 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08021833 chr19:5785663 PRR22;DUS3L -0.59 -6.54 -0.37 3.19e-10 Gut microbiome composition (summer); CESC trans rs2018683 0.707 rs917216 chr7:28971472 A/G cg19402173 chr7:128379420 CALU -0.53 -7.04 -0.4 1.63e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs7512552 0.839 rs1627235 chr1:150358858 C/T cg15654264 chr1:150340011 RPRD2 0.39 5.17 0.3 4.68e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.15 0.4 8.66e-12 Height; CESC cis rs7246657 0.943 rs7252325 chr19:37930645 A/G cg23950597 chr19:37808831 NA -0.55 -6.12 -0.35 3.28e-9 Coronary artery calcification; CESC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.96 0.8 1.36e-61 Prudent dietary pattern; CESC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg05332525 chr7:65337924 VKORC1L1 0.51 6.32 0.36 1.09e-9 Calcium levels; CESC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 10.36 0.54 2.36e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3749237 0.595 rs12489092 chr3:49550914 G/C cg06212747 chr3:49208901 KLHDC8B 0.49 6.61 0.38 2.15e-10 Resting heart rate; CESC cis rs4925325 0.876 rs6089560 chr20:60517325 T/G cg06108461 chr20:60628389 TAF4 -0.5 -5.96 -0.34 7.84e-9 Obesity-related traits; CESC cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.91e-28 Colonoscopy-negative controls vs population controls; CESC cis rs11203032 1.000 rs17117126 chr10:90964026 A/G cg16672925 chr10:90967113 CH25H 0.74 7.14 0.4 8.86e-12 Heart failure; CESC cis rs9457247 0.935 rs2149093 chr6:167373045 T/C cg23791538 chr6:167370224 RNASET2 0.57 8.19 0.45 1.13e-14 Crohn's disease; CESC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg17949981 chr6:28129498 ZNF389 -0.42 -5.16 -0.3 4.85e-7 Parkinson's disease; CESC cis rs2370759 1.000 rs11599044 chr10:32615445 A/G cg18270830 chr10:32634957 EPC1 0.7 6.77 0.38 8.3e-11 Sexual dysfunction (female); CESC cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg05283184 chr6:79620031 NA -0.43 -6.62 -0.38 1.97e-10 Intelligence (multi-trait analysis); CESC cis rs17023223 0.509 rs56195272 chr1:119713997 A/T cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs9929218 0.608 rs35158985 chr16:68796746 A/G cg02972257 chr16:68554789 NA 0.46 5.79 0.34 1.98e-8 Colorectal cancer; CESC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg06453172 chr10:134556979 INPP5A -0.43 -5.68 -0.33 3.47e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7264396 0.563 rs6060560 chr20:34278890 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.87 0.34 1.33e-8 Total cholesterol levels; CESC cis rs67311347 1.000 rs9834052 chr3:40399060 G/A cg01475735 chr3:40494733 NA -0.41 -5.27 -0.31 2.87e-7 Renal cell carcinoma; CESC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg27266060 chr8:22091797 NA 0.37 7.21 0.4 6.01e-12 Hypertriglyceridemia; CESC cis rs3008870 0.792 rs72673729 chr1:67441673 T/TG cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -14.1 -0.65 4.75e-34 Lymphocyte percentage of white cells; CESC cis rs2228479 0.867 rs76885005 chr16:89966668 A/G cg04013166 chr16:89971882 TCF25 0.76 7.2 0.4 6.4e-12 Skin colour saturation; CESC cis rs1538970 0.781 rs11211139 chr1:46015751 G/T cg03146154 chr1:46216737 IPP 0.52 5.81 0.34 1.78e-8 Platelet count; CESC cis rs7524258 0.868 rs7538921 chr1:7267007 T/C cg07173049 chr1:7289937 CAMTA1 0.46 6.75 0.38 9.34e-11 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs12541635 0.677 rs1006480 chr8:106975524 T/C cg10147462 chr8:107024639 NA 0.43 6.28 0.36 1.42e-9 Age of smoking initiation; CESC cis rs2180341 0.961 rs7774468 chr6:127592501 G/C cg24812749 chr6:127587940 RNF146 1.06 15.28 0.68 3.03e-38 Breast cancer; CESC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg26338869 chr17:61819248 STRADA 0.69 9.11 0.49 2.04e-17 Prudent dietary pattern; CESC cis rs7100689 0.646 rs1934693 chr10:82125650 T/C cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg02841227 chr6:26021843 HIST1H4A -0.41 -5.15 -0.3 5.2e-7 Intelligence (multi-trait analysis); CESC cis rs2302190 0.882 rs9903050 chr17:56636908 T/C cg25885038 chr17:56607967 SEPT4 -0.4 -5.43 -0.32 1.27e-7 Vitamin D levels; CESC cis rs7662987 1.000 rs7662987 chr4:99991642 T/C cg13256891 chr4:100009986 ADH5 -0.83 -6.09 -0.35 3.92e-9 Smoking initiation; CESC cis rs8180040 0.691 rs12489211 chr3:47221451 T/A cg27129171 chr3:47204927 SETD2 0.69 10.44 0.54 1.33e-21 Colorectal cancer; CESC cis rs2880765 0.714 rs6497187 chr15:86011350 A/G cg10818794 chr15:86012489 AKAP13 -0.35 -5.41 -0.32 1.42e-7 Coronary artery disease; CESC cis rs12478296 1.000 rs57603292 chr2:243028537 G/A cg06360820 chr2:242988706 NA -0.88 -8.78 -0.47 2.01e-16 Obesity-related traits; CESC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10009930 chr1:9599403 SLC25A33 0.59 7.08 0.4 1.27e-11 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -11.97 -0.59 1.09e-26 Alzheimer's disease; CESC cis rs10465746 0.967 rs4907191 chr1:84444165 A/G cg10977910 chr1:84465055 TTLL7 -0.48 -6.61 -0.38 2.05e-10 Obesity-related traits; CESC cis rs6121246 0.567 rs6120890 chr20:30207659 T/G cg13852791 chr20:30311386 BCL2L1 0.66 6.6 0.38 2.23e-10 Mean corpuscular hemoglobin; CESC cis rs10883723 0.738 rs3781290 chr10:104244948 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.44 0.42 1.39e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs13102973 0.965 rs4629509 chr4:135872410 C/T cg14419869 chr4:135874104 NA -0.4 -6.29 -0.36 1.32e-9 Subjective well-being; CESC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.12 0.81 3.97e-62 Prudent dietary pattern; CESC cis rs6121246 0.909 rs6087778 chr20:30354142 G/A cg13852791 chr20:30311386 BCL2L1 0.81 8.61 0.47 6.48e-16 Mean corpuscular hemoglobin; CESC cis rs568617 1.000 rs568617 chr11:65653242 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.69 7.43 0.42 1.47e-12 Crohn's disease; CESC cis rs10751667 0.600 rs10751672 chr11:948712 T/C cg20946044 chr11:1010712 AP2A2 -0.4 -5.52 -0.32 8.07e-8 Alzheimer's disease (late onset); CESC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.68 -8.68 -0.47 3.97e-16 Mean platelet volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21034903 chr2:172544336 DYNC1I2 0.41 6.49 0.37 4.18e-10 Gambling; CESC cis rs2985684 0.846 rs11157693 chr14:50048426 T/C cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.43 -5.25 -0.31 3.09e-7 Carotid intima media thickness; CESC cis rs10911251 0.546 rs2027084 chr1:183110801 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.1 0.63 1.49e-30 Colorectal cancer; CESC cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg17366294 chr4:99064904 C4orf37 0.58 8.34 0.46 4.23e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7833986 0.501 rs2668007 chr8:56944111 C/T cg26371346 chr8:56986568 SNORD54;RPS20 0.63 5.54 0.32 7.33e-8 Height; CESC trans rs634534 0.622 rs593525 chr11:65727799 T/C cg17712092 chr4:129076599 LARP1B 0.62 8.36 0.46 3.66e-15 Sum eosinophil basophil counts;Eosinophil counts; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17176517 chr3:125239027 SNX4 -0.48 -6.35 -0.36 9.14e-10 Ulcerative colitis; CESC cis rs644799 0.622 rs1255167 chr11:95500213 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.59 7.99 0.44 4.21e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4563143 0.675 rs56407818 chr19:29279379 G/A cg14983838 chr19:29218262 NA 0.49 5.71 0.33 3e-8 Methadone dose in opioid dependence; CESC cis rs11792861 0.816 rs7021366 chr9:111727670 C/G cg13535736 chr9:111863775 C9orf5 -0.48 -6.31 -0.36 1.16e-9 Menarche (age at onset); CESC cis rs7208859 0.623 rs216433 chr17:28921860 T/C cg17105886 chr17:28927953 LRRC37B2 0.61 5.4 0.31 1.47e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9300255 0.602 rs2510885 chr12:123614813 G/C cg00376283 chr12:123451042 ABCB9 0.68 8.55 0.47 9.82e-16 Neutrophil percentage of white cells; CESC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Depression; CESC cis rs3806843 0.868 rs2262574 chr5:140123635 G/T cg26395211 chr5:140044315 WDR55 0.4 5.13 0.3 5.51e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7659604 0.521 rs4240263 chr4:122683623 C/T cg19671926 chr4:122722719 EXOSC9 0.62 7.93 0.44 6.28e-14 Type 2 diabetes; CESC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg19163074 chr7:65112434 INTS4L2 0.46 5.57 0.32 6.37e-8 Aortic root size; CESC cis rs7116495 0.609 rs577435 chr11:71794681 C/T cg26138937 chr11:71823887 C11orf51 -1.26 -7.96 -0.44 5.12e-14 Severe influenza A (H1N1) infection; CESC cis rs4722585 0.533 rs6964215 chr7:26196819 G/A cg07876897 chr7:26191696 NFE2L3 0.41 5.17 0.3 4.66e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); CESC cis rs7098414 0.511 rs4934126 chr10:82151598 A/G cg00277334 chr10:82204260 NA -0.5 -7.37 -0.41 2.23e-12 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07343429 chr11:1785120 HCCA2;CTSD 0.56 6.32 0.36 1.08e-9 Gut microbiome composition (summer); CESC cis rs3812762 0.917 rs905289 chr11:8753552 A/G cg03980550 chr11:8754370 ST5 0.35 5.07 0.3 7.53e-7 Hypospadias; CESC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.58 -0.37 2.43e-10 Life satisfaction; CESC cis rs6580649 0.941 rs17122613 chr12:48460016 T/C cg24011408 chr12:48396354 COL2A1 -0.41 -5.27 -0.31 2.86e-7 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08115172 chr1:1990868 PRKCZ 0.44 6.08 0.35 4.21e-9 Fibrinogen levels; CESC cis rs3020736 0.500 rs6002605 chr22:42494335 A/G cg04733989 chr22:42467013 NAGA -0.83 -12.62 -0.61 6.45e-29 Autism spectrum disorder or schizophrenia; CESC cis rs926392 0.572 rs6129159 chr20:37675011 A/T cg16355469 chr20:37678765 NA 0.58 6.98 0.39 2.33e-11 Dialysis-related mortality; CESC cis rs9611519 0.542 rs8139770 chr22:41416181 C/T cg03806693 chr22:41940476 POLR3H -0.5 -5.82 -0.34 1.69e-8 Neuroticism; CESC cis rs1372520 0.684 rs2619347 chr4:90745770 G/A cg15133208 chr4:90757351 SNCA -0.4 -5.35 -0.31 1.87e-7 Neuroticism; CESC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg08470875 chr2:26401718 FAM59B 0.7 7.01 0.4 2.02e-11 Gut microbiome composition (summer); CESC cis rs6429082 0.608 rs4659836 chr1:235564412 G/A cg26050004 chr1:235667680 B3GALNT2 -0.55 -6.94 -0.39 3e-11 Adiposity; CESC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.62 0.33 4.71e-8 Bipolar disorder; CESC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg07308232 chr7:1071921 C7orf50 -0.55 -7.65 -0.43 3.77e-13 Longevity;Endometriosis; CESC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg03352830 chr11:487213 PTDSS2 0.77 7.6 0.42 5.08e-13 Body mass index; CESC cis rs6500395 0.926 rs7192297 chr16:48670421 G/A cg04672837 chr16:48644449 N4BP1 0.51 6.43 0.37 6.06e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs77106637 0.858 rs7109575 chr11:72463435 G/A cg04827223 chr11:72435913 ARAP1 -0.57 -5.44 -0.32 1.19e-7 Type 2 diabetes; CESC cis rs7216064 1.000 rs8079754 chr17:65887896 A/G cg07042672 chr17:66097459 LOC651250 -0.5 -5.28 -0.31 2.68e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs5763662 1.000 rs5753029 chr22:30557939 G/T cg21388335 chr22:29999516 NF2 -0.74 -5.04 -0.3 8.8e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs2243480 1.000 rs34560516 chr7:65404092 A/T cg13147721 chr7:65941812 NA -0.88 -8.15 -0.45 1.47e-14 Diabetic kidney disease; CESC cis rs9303280 0.901 rs2305479 chr17:38062217 C/T cg20243544 chr17:37824526 PNMT 0.54 7.29 0.41 3.53e-12 Self-reported allergy; CESC cis rs9300255 0.602 rs1790116 chr12:123618544 G/T cg19016782 chr12:123741754 C12orf65 -0.42 -5.93 -0.34 9.43e-9 Neutrophil percentage of white cells; CESC cis rs7078219 0.543 rs4919342 chr10:101282553 G/C cg09788492 chr10:101292477 NKX2-3 0.33 6.12 0.35 3.3e-9 Dental caries; CESC cis rs4319547 0.695 rs6488958 chr12:122880704 A/G cg05707623 chr12:122985044 ZCCHC8 -0.55 -6.3 -0.36 1.22e-9 Body mass index; CESC cis rs7116495 0.609 rs10793014 chr11:71698838 A/G cg26138937 chr11:71823887 C11orf51 -1.26 -8.07 -0.44 2.43e-14 Severe influenza A (H1N1) infection; CESC cis rs10899021 0.920 rs61901541 chr11:74317985 T/C cg25880958 chr11:74394337 NA -0.76 -7.95 -0.44 5.53e-14 Response to metformin (IC50); CESC cis rs9916302 0.706 rs903507 chr17:37726423 A/G cg20243544 chr17:37824526 PNMT 0.52 5.16 0.3 4.91e-7 Glomerular filtration rate (creatinine); CESC cis rs3105593 1.000 rs2899462 chr15:50939254 C/A cg08437265 chr15:50716283 USP8 0.41 5.26 0.31 2.94e-7 QT interval; CESC trans rs11039798 0.541 rs12283728 chr11:48796407 G/A cg15704280 chr7:45808275 SEPT13 0.7 6.31 0.36 1.18e-9 Axial length; CESC cis rs911555 0.723 rs6575991 chr14:103908433 C/T cg12935359 chr14:103987150 CKB 0.65 9.56 0.51 8.31e-19 Intelligence (multi-trait analysis); CESC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg26939375 chr7:64535504 NA 0.76 10.86 0.55 5.77e-23 Aortic root size; CESC cis rs892961 0.932 rs7207891 chr17:75413922 G/C cg05865280 chr17:75406074 SEPT9 0.62 12.5 0.61 1.65e-28 Airflow obstruction; CESC cis rs3096299 0.967 rs28575874 chr16:89469890 C/T cg08392591 chr16:89556376 ANKRD11 0.41 5.32 0.31 2.2e-7 Multiple myeloma (IgH translocation); CESC cis rs1185460 0.967 rs1786685 chr11:118938957 G/A cg01677386 chr11:118938358 VPS11 -0.43 -5.45 -0.32 1.14e-7 Coronary artery disease; CESC cis rs3859192 0.599 rs2227319 chr17:38170845 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.63 9.36 0.5 3.67e-18 White blood cell count; CESC cis rs9287719 0.967 rs10167129 chr2:10758575 G/A cg00105475 chr2:10696890 NA 0.37 5.4 0.31 1.52e-7 Prostate cancer; CESC cis rs7937682 0.632 rs12785809 chr11:111776055 T/A cg22437258 chr11:111473054 SIK2 -0.5 -5.5 -0.32 8.78e-8 Primary sclerosing cholangitis; CESC cis rs477692 0.647 rs11016853 chr10:131443990 A/G cg05714579 chr10:131428358 MGMT -0.6 -8.63 -0.47 5.73e-16 Response to temozolomide; CESC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg12756686 chr19:29218302 NA 0.44 6.27 0.36 1.48e-9 Methadone dose in opioid dependence; CESC cis rs11112613 0.775 rs12305225 chr12:105963266 G/C cg03607813 chr12:105948248 NA 0.48 5.62 0.33 4.79e-8 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg18180107 chr4:99064573 C4orf37 0.41 5.23 0.31 3.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs3858526 0.642 rs55732658 chr11:5894602 A/C cg13902645 chr11:5959945 NA -0.56 -6.72 -0.38 1.12e-10 DNA methylation (variation); CESC cis rs6083 0.571 rs56010348 chr15:58848120 T/G cg05156742 chr15:59063176 FAM63B -0.71 -9.99 -0.52 3.75e-20 Schizophrenia; CESC trans rs66573146 0.831 rs56320732 chr4:6974319 G/A cg07817883 chr1:32538562 TMEM39B 1.25 8.46 0.46 1.88e-15 Granulocyte percentage of myeloid white cells; CESC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.74 6.69 0.38 1.36e-10 Platelet count; CESC cis rs4604732 0.631 rs35046441 chr1:247626812 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs477692 1.000 rs485576 chr10:131425496 G/C cg05714579 chr10:131428358 MGMT 0.53 7.22 0.41 5.66e-12 Response to temozolomide; CESC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.51 -0.37 3.7e-10 Bipolar disorder; CESC cis rs1413885 0.549 rs1334877 chr1:65846406 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.46 6.14 0.35 3.05e-9 Anticoagulant levels; CESC cis rs6088590 0.502 rs6059861 chr20:33068563 A/T cg08999081 chr20:33150536 PIGU 0.66 11.81 0.59 3.83e-26 Coronary artery disease; CESC cis rs6570726 0.935 rs421268 chr6:145845558 A/T cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.96e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9814567 1.000 rs3846055 chr3:134203973 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.46 -6.26 -0.36 1.54e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs34779708 0.966 rs12784482 chr10:35446865 A/G cg04310649 chr10:35416472 CREM -0.51 -6.18 -0.35 2.39e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23549086 chr19:8008681 TIMM44 0.57 6.52 0.37 3.47e-10 Gut microbiome composition (summer); CESC cis rs9858542 0.953 rs9818590 chr3:49525096 A/G cg07274523 chr3:49395745 GPX1 0.66 8.05 0.44 2.82e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs11785400 0.793 rs11785376 chr8:143730412 C/T cg24634471 chr8:143751801 JRK 0.45 5.78 0.33 2.12e-8 Schizophrenia; CESC cis rs7429990 0.813 rs7637622 chr3:48093051 G/A cg11946769 chr3:48343235 NME6 -0.44 -5.37 -0.31 1.69e-7 Educational attainment (years of education); CESC cis rs6762 0.692 rs7928925 chr11:839155 G/A cg23754390 chr11:835074 CD151 0.31 5.34 0.31 2e-7 Mean platelet volume; CESC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg11663144 chr21:46675770 NA -0.63 -9.92 -0.52 6.25e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2072732 0.821 rs12033401 chr1:2944086 C/T cg15211996 chr1:2936768 ACTRT2 0.36 5.59 0.32 5.62e-8 Plateletcrit; CESC cis rs2594989 1.000 rs2594967 chr3:11349748 T/G cg00170343 chr3:11313890 ATG7 0.56 5.14 0.3 5.26e-7 Circulating chemerin levels; CESC cis rs8141529 0.504 rs6005915 chr22:29233262 A/G cg02153584 chr22:29168773 CCDC117 0.54 6.48 0.37 4.35e-10 Lymphocyte counts; CESC cis rs59918340 0.764 rs10101692 chr8:142230823 C/T cg23750338 chr8:142222470 SLC45A4 0.63 9.67 0.51 3.91e-19 Immature fraction of reticulocytes; CESC trans rs7246657 0.943 rs4803460 chr19:37885228 T/C cg24637308 chr11:6592297 DNHD1 0.53 6.08 0.35 4.15e-9 Coronary artery calcification; CESC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.54 7.95 0.44 5.39e-14 Intelligence (multi-trait analysis); CESC cis rs8078723 0.738 rs4065321 chr17:38143548 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.05 0.3 8.08e-7 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs997295 0.554 rs4261477 chr15:68073968 G/T cg08079166 chr15:68083412 MAP2K5 0.39 6.23 0.36 1.84e-9 Motion sickness; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07263984 chr5:115177777 ATG12;AP3S1 -0.52 -6.46 -0.37 4.91e-10 Asthma; CESC cis rs2120019 0.935 rs8043181 chr15:75380424 T/C cg09165964 chr15:75287851 SCAMP5 -0.68 -8.14 -0.45 1.5e-14 Blood trace element (Zn levels); CESC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg14393609 chr7:65229607 NA -0.45 -5.95 -0.34 8.52e-9 Aortic root size; CESC cis rs2439831 0.850 rs3742982 chr15:44176681 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.63 0.42 4.31e-13 Lung cancer in ever smokers; CESC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg06074448 chr4:187884817 NA 0.38 5.55 0.32 6.81e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.34 -0.31 2.02e-7 Lung cancer; CESC cis rs6430585 0.583 rs9636213 chr2:136589278 G/A cg07169764 chr2:136633963 MCM6 -1.15 -17.68 -0.74 9.35e-47 Corneal structure; CESC cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg10556349 chr10:835070 NA 0.53 5.09 0.3 6.75e-7 Eosinophil percentage of granulocytes; CESC cis rs7814319 0.870 rs2292836 chr8:97239613 A/C cg20787634 chr8:97240163 UQCRB -0.63 -8.18 -0.45 1.19e-14 Lung function (FVC); CESC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.41 5.99 0.35 6.89e-9 Total body bone mineral density; CESC cis rs2764980 1.000 rs2764978 chr10:3283385 C/G cg11630169 chr10:3283847 NA -0.37 -5.36 -0.31 1.84e-7 Attention deficit hyperactivity disorder and conduct disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19839691 chr15:64673790 KIAA0101 0.46 6.13 0.35 3.12e-9 Gut microbiota (bacterial taxa); CESC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg11663144 chr21:46675770 NA -0.56 -8.72 -0.47 3.04e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4523957 0.893 rs9909895 chr17:2161633 G/A cg16513277 chr17:2031491 SMG6 -0.6 -8.18 -0.45 1.22e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg08968635 chr6:28129556 ZNF389 0.41 5.28 0.31 2.68e-7 Parkinson's disease; CESC cis rs1003719 0.788 rs4817849 chr21:38469796 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs17401966 1.000 rs12132635 chr1:10430479 G/A cg15208524 chr1:10270712 KIF1B 0.49 6.21 0.36 2.06e-9 Hepatocellular carcinoma; CESC cis rs3026445 0.761 rs67917264 chr12:110554818 A/G cg12870014 chr12:110450643 ANKRD13A 0.46 5.9 0.34 1.13e-8 QT interval; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24696268 chr4:49526636 NA 0.44 6.13 0.35 3.17e-9 Ulcerative colitis; CESC cis rs96067 0.805 rs6425966 chr1:36611287 C/T cg24686825 chr1:36642396 MAP7D1 0.5 5.48 0.32 9.68e-8 Corneal structure; CESC cis rs5758511 0.508 rs2413667 chr22:42472237 A/C cg00645731 chr22:42541494 CYP2D7P1 0.56 7.6 0.42 5.14e-13 Birth weight; CESC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg17143192 chr8:8559678 CLDN23 0.75 8.87 0.48 1.11e-16 Obesity-related traits; CESC cis rs11190604 1.000 rs9420782 chr10:102235015 G/A cg07080220 chr10:102295463 HIF1AN 0.55 5.52 0.32 8.2e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs2952156 0.920 rs2247862 chr17:37829129 A/G cg00129232 chr17:37814104 STARD3 -0.72 -9.63 -0.51 5.06e-19 Asthma; CESC cis rs11650494 0.908 rs57390430 chr17:47374886 G/A cg08112188 chr17:47440006 ZNF652 1.11 7.71 0.43 2.48e-13 Prostate cancer; CESC cis rs3771570 1.000 rs62193221 chr2:242354632 T/C cg21155796 chr2:242212141 HDLBP 0.58 5.06 0.3 7.83e-7 Prostate cancer; CESC trans rs17508449 0.819 rs3761934 chr1:114189067 G/T cg23028848 chr11:57092561 TNKS1BP1 -0.75 -6.05 -0.35 4.88e-9 Leprosy; CESC cis rs61931739 0.500 rs7311302 chr12:34557211 T/C cg06521331 chr12:34319734 NA -0.36 -5.03 -0.3 9.01e-7 Morning vs. evening chronotype; CESC cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg16339924 chr4:17578868 LAP3 0.64 8.12 0.45 1.79e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs116095464 0.558 rs10462754 chr5:246669 T/C cg00938859 chr5:1591904 SDHAP3 0.63 6.92 0.39 3.29e-11 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14159818 chr20:3749519 C20orf27 0.48 6.55 0.37 3.01e-10 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.08 0.3 7.07e-7 Colonoscopy-negative controls vs population controls; CESC trans rs7937682 0.889 rs1940529 chr11:111498523 G/C cg18187862 chr3:45730750 SACM1L 0.51 6.4 0.37 7.15e-10 Primary sclerosing cholangitis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg08882882 chr6:84937375 KIAA1009 -0.46 -6.21 -0.36 2.06e-9 Height; CESC cis rs4653767 0.573 rs708770 chr1:226912135 C/T cg10327440 chr1:227177885 CDC42BPA -0.42 -5.58 -0.32 5.99e-8 Parkinson's disease; CESC cis rs9457247 1.000 rs385863 chr6:167386615 C/G cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC trans rs561341 0.941 rs736678 chr17:30347423 G/T cg27661571 chr11:113659931 NA -0.83 -7.34 -0.41 2.56e-12 Hip circumference adjusted for BMI; CESC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg26314531 chr2:26401878 FAM59B -0.82 -9.04 -0.49 3.33e-17 Gut microbiome composition (summer); CESC cis rs9549367 0.756 rs9603814 chr13:113900782 C/T cg00898013 chr13:113819073 PROZ 0.5 7.38 0.41 2.06e-12 Platelet distribution width; CESC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 11.76 0.59 5.69e-26 Platelet count; CESC cis rs2836633 0.929 rs2836610 chr21:40044502 C/T cg12884169 chr21:40033163 ERG 0.39 6.09 0.35 3.99e-9 Coronary artery disease; CESC cis rs8005677 1.000 rs4982712 chr14:23403728 A/G cg01529538 chr14:23388837 RBM23 0.5 6.56 0.37 2.83e-10 Cognitive ability (multi-trait analysis); CESC cis rs9611565 0.694 rs7285041 chr22:41829149 G/T cg17376030 chr22:41985996 PMM1 -0.76 -8.1 -0.45 2.03e-14 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19857114 chr3:176741225 TBL1XR1 -0.59 -6.55 -0.37 2.99e-10 Gut microbiome composition (summer); CESC cis rs8067354 0.872 rs2645488 chr17:57889405 T/G cg02344993 chr17:57696989 CLTC 0.48 6.3 0.36 1.2e-9 Hemoglobin concentration; CESC cis rs11098499 0.954 rs66506550 chr4:120371445 T/A cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg12463550 chr7:65579703 CRCP -0.51 -6.5 -0.37 3.9e-10 Aortic root size; CESC cis rs7173419 0.716 rs7162812 chr15:28233734 G/A cg20906524 chr15:28200668 OCA2 -0.42 -5.86 -0.34 1.39e-8 Eye color; CESC cis rs4629180 0.675 rs6742474 chr2:102091075 G/A cg21388029 chr2:102003306 CREG2 0.34 5.36 0.31 1.82e-7 Chronic rhinosinusitis with nasal polyps; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg04078585 chr17:71165907 SSTR2 0.45 6.29 0.36 1.31e-9 Recombination measurement; CESC cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg03684893 chr10:554711 DIP2C -0.35 -5.1 -0.3 6.52e-7 Psychosis in Alzheimer's disease; CESC cis rs2282802 0.685 rs35214989 chr5:139636127 T/C cg26211634 chr5:139558579 C5orf32 0.49 7.1 0.4 1.13e-11 Intelligence (multi-trait analysis); CESC cis rs8038465 0.904 rs11852484 chr15:73988652 G/A cg15420318 chr15:73925796 NPTN 0.41 5.67 0.33 3.71e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs71277158 0.688 rs16854836 chr3:169804730 T/C cg04067573 chr3:169899625 PHC3 0.67 6.83 0.39 5.86e-11 Prostate cancer; CESC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg11764359 chr7:65958608 NA 0.96 15.23 0.68 4.78e-38 Aortic root size; CESC cis rs1707322 0.896 rs809774 chr1:46560244 T/A cg03146154 chr1:46216737 IPP -0.69 -9.1 -0.49 2.16e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs5769765 1.000 rs738711 chr22:50282603 A/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09965679 chr14:75179859 FCF1;KIAA0317 -0.53 -6.23 -0.36 1.87e-9 Gut microbiome composition (summer); CESC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.74 9.73 0.51 2.47e-19 Height; CESC cis rs7072216 0.763 rs9787550 chr10:100169051 C/T cg26618903 chr10:100175079 PYROXD2 -0.36 -5.53 -0.32 7.84e-8 Metabolite levels; CESC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg02896835 chr1:92012615 NA -0.53 -6.87 -0.39 4.57e-11 Breast cancer; CESC cis rs2573652 1.000 rs2727199 chr15:100514417 C/T cg09918751 chr15:100517450 ADAMTS17 -0.39 -7.21 -0.4 5.96e-12 Height; CESC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg00784671 chr22:46762841 CELSR1 -0.49 -5.59 -0.32 5.56e-8 LDL cholesterol;Cholesterol, total; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08695707 chr1:197871847 C1orf53 0.46 6.11 0.35 3.62e-9 Systemic lupus erythematosus; CESC cis rs1538970 0.816 rs9727262 chr1:45998579 T/G cg06784218 chr1:46089804 CCDC17 0.35 5.63 0.33 4.57e-8 Platelet count; CESC cis rs7621025 0.505 rs61789642 chr3:136109696 C/T cg15507776 chr3:136538369 TMEM22 -0.73 -5.84 -0.34 1.56e-8 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs873946 0.564 rs12242672 chr10:134555609 A/T cg06453172 chr10:134556979 INPP5A -0.4 -5.32 -0.31 2.19e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1506636 1.000 rs10225428 chr7:123357646 A/G cg03229431 chr7:123269106 ASB15 -0.49 -6.57 -0.37 2.58e-10 Plateletcrit;Platelet count; CESC cis rs10791097 0.694 rs1893017 chr11:130756253 C/T cg09137382 chr11:130731461 NA 0.34 5.1 0.3 6.52e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9649465 1.000 rs12537287 chr7:123364747 G/A cg04330084 chr7:123175371 IQUB -0.39 -5.23 -0.31 3.47e-7 Migraine; CESC cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg04317338 chr11:64019027 PLCB3 0.47 5.62 0.33 4.95e-8 Platelet count; CESC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg02398342 chr17:80708632 TBCD;FN3K -0.5 -6.76 -0.38 8.98e-11 Glycated hemoglobin levels; CESC cis rs6541297 0.878 rs4846905 chr1:230279582 C/T cg05784532 chr1:230284198 GALNT2 -0.43 -5.45 -0.32 1.13e-7 Coronary artery disease; CESC cis rs763121 0.849 rs12004 chr22:38877461 T/G cg06022373 chr22:39101656 GTPBP1 0.81 11.63 0.58 1.51e-25 Menopause (age at onset); CESC trans rs1814175 0.791 rs10769593 chr11:49616217 T/C cg15704280 chr7:45808275 SEPT13 -0.98 -18.02 -0.74 6.21e-48 Height; CESC cis rs1559088 0.948 rs12460195 chr19:33584479 G/A cg17764715 chr19:33622953 WDR88 0.49 6.32 0.36 1.11e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs501120 0.925 rs684521 chr10:44752523 G/A cg09554077 chr10:44749378 NA 0.55 7.18 0.4 6.98e-12 Coronary artery disease;Coronary heart disease; CESC cis rs11098499 0.865 rs10213221 chr4:120255926 G/A cg09307838 chr4:120376055 NA 0.81 10.99 0.56 2.15e-23 Corneal astigmatism; CESC cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg22875332 chr1:76189707 ACADM 0.62 7.17 0.4 7.45e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg15145296 chr3:125709740 NA -0.54 -5.73 -0.33 2.67e-8 Blood pressure (smoking interaction); CESC cis rs3820068 0.705 rs2145397 chr1:15896199 G/A cg17385448 chr1:15911702 AGMAT 0.36 5.52 0.32 8.12e-8 Systolic blood pressure; CESC cis rs1580019 0.961 rs3801328 chr7:32496930 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.15 0.53 1.14e-20 Cognitive ability; CESC cis rs854765 0.583 rs8080823 chr17:17864048 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.55 7.47 0.42 1.16e-12 Total body bone mineral density; CESC cis rs3806843 0.771 rs2563334 chr5:140107065 C/G cg16179182 chr5:140090404 VTRNA1-1 0.44 5.74 0.33 2.54e-8 Depressive symptoms (multi-trait analysis); CESC cis rs709400 1.000 rs7150141 chr14:104129352 G/A cg12935359 chr14:103987150 CKB -0.43 -5.84 -0.34 1.54e-8 Body mass index; CESC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg19099843 chr7:12443191 VWDE -0.5 -5.26 -0.31 2.97e-7 Coronary artery disease; CESC cis rs6665290 0.935 rs17600627 chr1:227201449 A/G cg10327440 chr1:227177885 CDC42BPA -1.19 -30.52 -0.88 1.02e-88 Myeloid white cell count; CESC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg24733560 chr20:60626293 TAF4 0.47 6.72 0.38 1.09e-10 Body mass index; CESC cis rs3733585 0.638 rs17185835 chr4:9958180 T/G cg00071950 chr4:10020882 SLC2A9 -0.72 -11.7 -0.58 8.89e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg13298116 chr11:62369859 EML3;MTA2 0.61 9.27 0.49 6.61e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs9309473 0.847 rs4547554 chr2:73867862 G/C cg20560298 chr2:73613845 ALMS1 -0.53 -6.79 -0.39 7.23e-11 Metabolite levels; CESC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs9611519 0.964 rs20551 chr22:41548008 A/G cg03806693 chr22:41940476 POLR3H -0.63 -6.34 -0.36 9.61e-10 Neuroticism; CESC cis rs7537052 0.669 rs475591 chr1:36642420 T/C cg24686825 chr1:36642396 MAP7D1 -0.72 -10.23 -0.53 6.26e-21 Schizophrenia; CESC cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC cis rs7647973 1.000 rs13322887 chr3:49555583 G/A cg02487422 chr3:49467188 NICN1 -0.41 -5.35 -0.31 1.86e-7 Menarche (age at onset); CESC cis rs4253772 0.513 rs9306512 chr22:46716603 T/C cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.56 6.03 0.35 5.48e-9 LDL cholesterol;Cholesterol, total; CESC cis rs1348850 0.632 rs12471621 chr2:178502353 T/C cg23306229 chr2:178417860 TTC30B 0.6 7.57 0.42 6.27e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg06221963 chr1:154839813 KCNN3 -0.66 -11.21 -0.57 4.07e-24 Prostate cancer; CESC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.63 8.19 0.45 1.1e-14 Prudent dietary pattern; CESC cis rs6728642 0.708 rs56807297 chr2:97861340 A/C cg26665480 chr2:98280029 ACTR1B -0.8 -7.2 -0.4 6.39e-12 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs2742234 0.579 rs2503881 chr10:43686026 T/C cg07801480 chr10:43725741 RASGEF1A 0.41 5.29 0.31 2.56e-7 Hirschsprung disease; CESC cis rs2295359 0.892 rs12401432 chr1:67656931 C/G cg03340356 chr1:67600835 NA 0.32 5.27 0.31 2.81e-7 Psoriasis; CESC trans rs2415984 0.846 rs8022067 chr14:46851304 C/A cg14945696 chr3:52713679 PBRM1 -0.39 -6.04 -0.35 5.21e-9 Number of children ever born; CESC cis rs7107174 1.000 rs10899460 chr11:78010080 A/G cg02023728 chr11:77925099 USP35 0.5 6.66 0.38 1.62e-10 Testicular germ cell tumor; CESC cis rs910316 0.737 rs108621 chr14:75480637 T/C cg08847533 chr14:75593920 NEK9 -0.88 -15.06 -0.68 1.95e-37 Height; CESC cis rs2346177 0.519 rs35509718 chr2:46696793 T/C cg02822958 chr2:46747628 ATP6V1E2 0.45 5.59 0.32 5.67e-8 HDL cholesterol; CESC cis rs634534 0.561 rs14157 chr11:65769780 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.84 0.39 5.62e-11 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs10883723 0.773 rs2296587 chr10:104245588 G/A cg22532475 chr10:104410764 TRIM8 -0.43 -6.72 -0.38 1.14e-10 Allergic disease (asthma, hay fever or eczema); CESC cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7726839 0.540 rs3749615 chr5:601485 C/T cg16447950 chr5:562315 NA -0.61 -6.31 -0.36 1.19e-9 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07797907 chr16:2389905 ABCA17P;ABCA3 -0.48 -6.64 -0.38 1.73e-10 Fibrinogen levels; CESC cis rs9796 0.870 rs8030306 chr15:41261821 T/A cg18705301 chr15:41695430 NDUFAF1 -0.47 -6.97 -0.39 2.55e-11 Menopause (age at onset); CESC cis rs35955747 0.714 rs5997989 chr22:31839950 T/C cg25791279 chr22:32026902 PISD -0.41 -5.03 -0.3 9.17e-7 Neutrophil count;Sum basophil neutrophil counts; CESC trans rs17716202 0.702 rs16885789 chr5:55897825 A/G cg14306956 chr9:37027384 PAX5 -0.59 -6.28 -0.36 1.37e-9 Psychosis in Alzheimer's disease; CESC cis rs6686643 1.000 rs959617 chr1:165616881 C/G cg19407955 chr1:165599744 MGST3 -0.48 -5.2 -0.3 3.93e-7 Total ventricular volume; CESC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg08470875 chr2:26401718 FAM59B -0.62 -6.71 -0.38 1.2e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25180585 chr17:49230756 NME1;NME1-NME2 0.66 7.72 0.43 2.42e-13 Gut microbiome composition (summer); CESC cis rs7584330 0.554 rs2325838 chr2:238386515 C/A cg14458575 chr2:238380390 NA 0.67 5.72 0.33 2.87e-8 Prostate cancer; CESC cis rs10129255 0.500 rs1974468 chr14:107142166 A/G cg07958169 chr14:107095056 NA -0.56 -9.0 -0.48 4.47e-17 Kawasaki disease; CESC cis rs9796 0.689 rs11855797 chr15:41434679 C/T cg12426344 chr15:41135900 SPINT1 -0.24 -5.31 -0.31 2.37e-7 Menopause (age at onset); CESC cis rs9905704 0.681 rs7211133 chr17:56558918 G/A cg12560992 chr17:57184187 TRIM37 -0.59 -5.55 -0.32 6.76e-8 Testicular germ cell tumor; CESC cis rs7100689 0.646 rs1340375 chr10:82129039 C/T cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs7937682 0.883 rs484834 chr11:111465761 G/C cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC trans rs57221529 0.766 rs72706608 chr5:559203 C/T cg25482853 chr8:67687455 SGK3 1.11 11.94 0.59 1.39e-26 Lung disease severity in cystic fibrosis; CESC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs722599 0.748 rs59112602 chr14:75358817 C/G cg11812906 chr14:75593930 NEK9 -0.46 -5.51 -0.32 8.57e-8 IgG glycosylation; CESC cis rs7336332 0.600 rs9579083 chr13:28017270 G/C cg22138327 chr13:27999177 GTF3A 0.63 5.74 0.33 2.57e-8 Weight; CESC cis rs1707322 1.000 rs11211228 chr1:46399840 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2777491 1.000 rs2777491 chr15:41735710 T/G cg02330683 chr15:41787940 ITPKA 0.47 7.03 0.4 1.76e-11 Ulcerative colitis; CESC cis rs4727027 0.866 rs10435245 chr7:148816081 C/G cg23583168 chr7:148888333 NA -0.78 -12.19 -0.6 1.97e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11098499 0.648 rs2002047 chr4:120257228 A/G cg25214090 chr10:38739885 LOC399744 0.64 9.08 0.49 2.59e-17 Corneal astigmatism; CESC cis rs4474465 0.790 rs6592784 chr11:78234790 C/T cg02023728 chr11:77925099 USP35 -0.41 -5.09 -0.3 6.75e-7 Alzheimer's disease (survival time); CESC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg05564831 chr3:52568323 NT5DC2 0.44 6.58 0.37 2.57e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10081115 chr2:190686883 PMS1 -0.62 -6.51 -0.37 3.8e-10 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg00149659 chr3:10157352 C3orf10 0.74 9.04 0.49 3.31e-17 Alzheimer's disease; CESC cis rs67478160 0.608 rs34066659 chr14:104263427 A/C cg08213375 chr14:104286397 PPP1R13B 0.54 10.8 0.55 8.68e-23 Schizophrenia; CESC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC trans rs55704346 0.534 rs6448354 chr4:25389584 A/C cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs1707322 0.686 rs1084086 chr1:46041100 A/C cg05343316 chr1:45956843 TESK2 -0.53 -6.53 -0.37 3.33e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10924309 0.924 rs10802245 chr1:245858321 G/A cg00036263 chr1:245852353 KIF26B -0.42 -5.22 -0.31 3.69e-7 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg27286337 chr10:134555280 INPP5A 0.65 8.4 0.46 2.71e-15 Migraine; CESC cis rs4948102 0.642 rs766333 chr7:56126704 T/A cg09872392 chr7:56161020 PHKG1 -0.46 -7.55 -0.42 7.19e-13 Plasma homocysteine levels (post-methionine load test); CESC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg25036284 chr2:26402008 FAM59B 0.52 6.4 0.37 7.18e-10 Gut microbiome composition (summer); CESC cis rs8180040 0.966 rs11130128 chr3:47486632 T/C cg27129171 chr3:47204927 SETD2 -0.63 -9.47 -0.5 1.6e-18 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15144236 chr6:144385792 PLAGL1 0.58 6.76 0.38 8.55e-11 Gut microbiome composition (summer); CESC cis rs11785400 1.000 rs754957 chr8:143746416 A/G cg10596483 chr8:143751796 JRK 0.43 5.67 0.33 3.79e-8 Schizophrenia; CESC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg08027265 chr7:2291960 NA -0.46 -7.08 -0.4 1.27e-11 Bipolar disorder and schizophrenia; CESC cis rs1256061 0.603 rs1256039 chr14:64738979 G/C cg23250157 chr14:64679961 SYNE2 0.53 7.64 0.42 4.09e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg08736216 chr1:53307985 ZYG11A 0.32 5.66 0.33 3.97e-8 Monocyte count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02602601 chr12:56618057 OBFC2B -0.49 -6.43 -0.37 5.9e-10 Ulcerative colitis; CESC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg22535103 chr8:58192502 C8orf71 -0.96 -9.81 -0.52 1.45e-19 Developmental language disorder (linguistic errors); CESC cis rs9325144 0.560 rs10876005 chr12:39126149 C/G cg26384229 chr12:38710491 ALG10B -0.51 -7.46 -0.42 1.23e-12 Morning vs. evening chronotype; CESC cis rs36051895 0.589 rs6476948 chr9:5204404 C/T cg02405213 chr9:5042618 JAK2 -0.49 -5.69 -0.33 3.41e-8 Pediatric autoimmune diseases; CESC cis rs2066819 1.000 rs77447765 chr12:56690662 G/A cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs12824058 0.831 rs4759653 chr12:130812604 T/C cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs5753618 0.561 rs9609264 chr22:31746719 C/G cg13145458 chr22:31556086 RNF185 -0.49 -5.57 -0.32 6.31e-8 Colorectal cancer; CESC cis rs896543 0.515 rs62189825 chr2:237494954 C/T cg25295825 chr2:237489920 CXCR7 0.66 5.85 0.34 1.47e-8 Alcohol dependence (age at onset); CESC cis rs9457247 0.515 rs2757039 chr6:167370353 G/T cg23791538 chr6:167370224 RNASET2 0.69 9.94 0.52 5.51e-20 Crohn's disease; CESC cis rs113835537 0.808 rs10896128 chr11:66324529 G/A cg24851651 chr11:66362959 CCS 0.55 5.29 0.31 2.6e-7 Airway imaging phenotypes; CESC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 10.96 0.56 2.75e-23 Platelet count; CESC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.7 0.62 3.48e-29 Alzheimer's disease; CESC cis rs2439831 0.717 rs2447198 chr15:43895118 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.81 8.75 0.47 2.56e-16 Lung cancer in ever smokers; CESC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.37 0.41 2.21e-12 Electroencephalogram traits; CESC cis rs17253792 0.822 rs10083303 chr14:56068521 T/C cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15249164 chr21:35288186 ATP5O -0.37 -6.09 -0.35 4.03e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03438090 chr2:239143093 NA 0.57 6.27 0.36 1.49e-9 Gut microbiome composition (summer); CESC cis rs4595586 0.545 rs11615634 chr12:39364704 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.7 0.43 2.7e-13 Morning vs. evening chronotype; CESC cis rs7914558 1.000 rs67908413 chr10:104764989 T/C cg04362960 chr10:104952993 NT5C2 0.46 6.13 0.35 3.2e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg17376030 chr22:41985996 PMM1 0.6 6.42 0.37 6.13e-10 Vitiligo; CESC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg12648201 chr2:27665141 KRTCAP3 -0.37 -6.94 -0.39 2.95e-11 Total body bone mineral density; CESC cis rs4268898 0.662 rs2303291 chr2:24431184 C/T cg20701182 chr2:24300061 SF3B14 0.69 7.17 0.4 7.69e-12 Asthma; CESC cis rs9814567 1.000 rs6765505 chr3:134208132 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.98 -0.34 7.11e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg11764359 chr7:65958608 NA 0.71 9.39 0.5 2.85e-18 Aortic root size; CESC cis rs7267979 0.932 rs928121 chr20:25534818 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.75 13.63 0.64 2.09e-32 Liver enzyme levels (alkaline phosphatase); CESC cis rs8064299 0.597 rs2016126 chr17:72784932 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.83 13.98 0.65 1.23e-33 Monocyte count; CESC cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg06115741 chr20:33292138 TP53INP2 -0.48 -5.82 -0.34 1.66e-8 Coronary artery disease; CESC cis rs9300255 0.544 rs1790100 chr12:123656725 G/T cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.19e-16 Neutrophil percentage of white cells; CESC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg14703610 chr5:56206110 C5orf35 -0.41 -5.19 -0.3 4.15e-7 Initial pursuit acceleration; CESC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg00149659 chr3:10157352 C3orf10 0.7 8.26 0.45 6.82e-15 Alzheimer's disease; CESC cis rs7903847 0.619 rs76094900 chr10:99158164 G/A cg20016023 chr10:99160130 RRP12 -0.3 -5.14 -0.3 5.4e-7 Granulocyte percentage of myeloid white cells; CESC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg13880726 chr7:1868755 MAD1L1 0.5 6.63 0.38 1.86e-10 Bipolar disorder and schizophrenia; CESC trans rs10411161 0.702 rs8110073 chr19:52383123 C/A cg22319618 chr22:45562946 NUP50 -0.69 -6.55 -0.37 2.98e-10 Breast cancer; CESC cis rs3749237 0.576 rs3877784 chr3:49539417 C/T cg06212747 chr3:49208901 KLHDC8B 0.49 6.55 0.37 3.02e-10 Resting heart rate; CESC cis rs7789940 0.809 rs12533836 chr7:75935622 G/T cg10167463 chr7:75959203 YWHAG -0.44 -5.2 -0.3 3.99e-7 Multiple sclerosis; CESC cis rs9916302 0.904 rs2061338 chr17:37421767 T/C cg20243544 chr17:37824526 PNMT 0.46 5.76 0.33 2.31e-8 Glomerular filtration rate (creatinine); CESC cis rs1728785 0.892 rs1170427 chr16:68603852 G/T cg02972257 chr16:68554789 NA -0.59 -6.71 -0.38 1.2e-10 Ulcerative colitis; CESC cis rs763121 0.853 rs6001175 chr22:39018334 T/C cg06022373 chr22:39101656 GTPBP1 0.95 17.19 0.73 5.31e-45 Menopause (age at onset); CESC cis rs7267979 0.773 rs6132821 chr20:25226192 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.72 11.88 0.59 2.28e-26 Liver enzyme levels (alkaline phosphatase); CESC cis rs36051895 0.632 rs12337904 chr9:5144606 C/G cg02405213 chr9:5042618 JAK2 -0.51 -6.4 -0.37 7.16e-10 Pediatric autoimmune diseases; CESC cis rs1006703 0.544 rs8068346 chr17:3838717 T/C cg06463185 chr17:3833770 ATP2A3 -0.63 -6.05 -0.35 5.04e-9 Glucose homeostasis traits; CESC cis rs9916302 0.904 rs602688 chr17:37439496 C/T cg20243544 chr17:37824526 PNMT 0.46 5.92 0.34 9.84e-9 Glomerular filtration rate (creatinine); CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg25934064 chr3:52569026 NT5DC2 0.26 5.5 0.32 9.11e-8 Cognitive function; CESC cis rs1799949 0.965 rs8070179 chr17:41202688 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.44 6.23 0.36 1.86e-9 Menopause (age at onset); CESC cis rs4474465 0.646 rs10793337 chr11:78285875 A/T cg01578073 chr11:78285783 NARS2 -0.45 -5.11 -0.3 6.27e-7 Alzheimer's disease (survival time); CESC cis rs8071789 1.000 rs8071789 chr17:38006333 C/T cg19468946 chr17:37922297 IKZF3 -0.37 -5.07 -0.3 7.42e-7 Selective IgA deficiency; CESC cis rs796364 0.951 rs12996313 chr2:200997916 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.73 -0.38 1.06e-10 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03410407 chr10:39023676 NA -0.58 -6.24 -0.36 1.73e-9 Gut microbiome composition (summer); CESC cis rs11240074 0.516 rs55679008 chr1:146919919 A/G cg25205988 chr1:146714368 CHD1L -0.64 -5.26 -0.31 2.92e-7 Type 2 diabetes; CESC cis rs2463822 0.583 rs72917377 chr11:62025930 A/G cg06239285 chr11:62104954 ASRGL1 -1.05 -7.91 -0.44 7.04e-14 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13597198 chr19:3208049 NCLN -0.57 -6.37 -0.36 8.24e-10 Gut microbiome composition (summer); CESC cis rs6963495 0.719 rs73190172 chr7:105161210 T/C cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs9527 0.590 rs11191578 chr10:104902337 A/T cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16138787 chr5:107929274 NA -0.59 -7.12 -0.4 1.03e-11 Gut microbiome composition (summer); CESC cis rs7084402 1.000 rs6481401 chr10:60268880 A/C cg07615347 chr10:60278583 BICC1 -0.57 -8.72 -0.47 3.03e-16 Refractive error; CESC cis rs12898370 0.641 rs11632999 chr15:77436995 T/G cg17802220 chr15:77601643 NA -0.52 -5.61 -0.33 4.96e-8 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs5758659 0.652 rs133313 chr22:42401749 G/T cg15557168 chr22:42548783 NA -0.42 -6.17 -0.35 2.52e-9 Cognitive function; CESC cis rs561341 1.000 rs55643307 chr17:30263074 T/C cg19193384 chr17:30244184 NA -0.65 -5.94 -0.34 8.95e-9 Hip circumference adjusted for BMI; CESC trans rs9850225 0.719 rs4856616 chr3:80466481 A/C cg22465281 chr5:65017296 NLN;SGTB -0.38 -6.03 -0.35 5.61e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs7208859 0.623 rs55638872 chr17:29149552 G/C cg13385521 chr17:29058706 SUZ12P 0.8 6.38 0.37 7.71e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4474465 0.688 rs7942527 chr11:78280322 A/G cg01578073 chr11:78285783 NARS2 -0.44 -5.1 -0.3 6.33e-7 Alzheimer's disease (survival time); CESC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg17294928 chr15:75287854 SCAMP5 0.51 6.95 0.39 2.85e-11 Breast cancer; CESC trans rs11098499 0.863 rs11098532 chr4:120490726 C/A cg25214090 chr10:38739885 LOC399744 0.64 8.66 0.47 4.67e-16 Corneal astigmatism; CESC cis rs3749237 0.595 rs6784820 chr3:49450864 C/T cg03060546 chr3:49711283 APEH -0.74 -11.37 -0.57 1.15e-24 Resting heart rate; CESC cis rs4253772 0.872 rs4253776 chr22:46629479 C/T cg00784671 chr22:46762841 CELSR1 0.43 5.41 0.32 1.41e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7523050 0.643 rs35924015 chr1:109404626 T/C cg08274380 chr1:109419600 GPSM2 0.82 5.78 0.33 2.08e-8 Fat distribution (HIV); CESC cis rs6032067 0.777 rs34855539 chr20:43799036 T/G cg10761708 chr20:43804764 PI3 0.55 6.57 0.37 2.7e-10 Blood protein levels; CESC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.62 8.41 0.46 2.62e-15 Menopause (age at onset); CESC cis rs523522 0.962 rs9788155 chr12:120938408 G/A cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs1949733 1.000 rs1949733 chr4:8503359 C/T cg11789530 chr4:8429930 ACOX3 -0.74 -10.53 -0.54 7.09e-22 Response to antineoplastic agents; CESC cis rs7703051 0.864 rs6873472 chr5:74768347 C/A cg03227963 chr5:74354835 NA 0.29 5.35 0.31 1.93e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs8017423 0.615 rs12586761 chr14:90820897 A/G cg14092571 chr14:90743983 NA 0.43 6.55 0.37 2.93e-10 Mortality in heart failure; CESC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.55 -0.42 7.15e-13 Gut microbiome composition (summer); CESC cis rs6460942 0.597 rs17448913 chr7:12533984 T/C cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC cis rs4835473 0.771 rs4443231 chr4:144900654 A/G cg25736465 chr4:144833511 NA 0.4 6.03 0.35 5.56e-9 Immature fraction of reticulocytes; CESC cis rs9611565 0.592 rs5758427 chr22:42099688 A/G cg03806693 chr22:41940476 POLR3H 1.05 11.94 0.59 1.39e-26 Vitiligo; CESC cis rs9916302 0.904 rs4795357 chr17:37569551 T/C cg15445000 chr17:37608096 MED1 0.4 6.35 0.36 9.2e-10 Glomerular filtration rate (creatinine); CESC cis rs4474465 0.688 rs4945302 chr11:78283454 T/C cg27205649 chr11:78285834 NARS2 0.48 6.31 0.36 1.14e-9 Alzheimer's disease (survival time); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05414835 chr15:59225898 SLTM -0.57 -6.57 -0.37 2.7e-10 Gut microbiome composition (summer); CESC cis rs12950390 0.853 rs28589850 chr17:45855713 A/G cg00777063 chr17:45855553 NA -0.39 -5.83 -0.34 1.6e-8 IgG glycosylation; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg10352719 chr14:24769404 DHRS1;C14orf21 -0.47 -6.37 -0.36 8.24e-10 Height; CESC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3008870 1.000 rs12039172 chr1:67447450 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -14.57 -0.67 9.76e-36 Lymphocyte percentage of white cells; CESC cis rs67478160 0.643 rs876002 chr14:104239697 G/A cg01849466 chr14:104193079 ZFYVE21 -0.5 -6.89 -0.39 4.13e-11 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00419759 chr1:114301964 PHTF1 0.58 7.48 0.42 1.11e-12 Gut microbiota (bacterial taxa); CESC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg12193833 chr17:30244370 NA -0.72 -7.38 -0.41 2.07e-12 Hip circumference adjusted for BMI; CESC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg19077165 chr18:44547161 KATNAL2 -0.53 -7.64 -0.42 3.99e-13 Personality dimensions; CESC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg09323728 chr8:95962352 TP53INP1 0.36 6.98 0.39 2.32e-11 Type 2 diabetes; CESC cis rs1799949 0.965 rs8070179 chr17:41202688 G/A cg25072359 chr17:41440525 NA 0.48 7.22 0.41 5.65e-12 Menopause (age at onset); CESC cis rs2235544 0.565 rs605182 chr1:54466956 A/G cg25741118 chr1:54482237 LDLRAD1 0.24 5.8 0.34 1.91e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs4268898 0.662 rs2303296 chr2:24432839 A/G cg08917208 chr2:24149416 ATAD2B 0.55 5.27 0.31 2.89e-7 Asthma; CESC cis rs11098499 0.657 rs9996569 chr4:120299004 G/C cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs7582720 0.943 rs72934762 chr2:203756677 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs796364 0.806 rs76568708 chr2:200929531 C/T cg23649088 chr2:200775458 C2orf69 -0.59 -5.36 -0.31 1.78e-7 Schizophrenia; CESC cis rs34638657 0.646 rs72628279 chr16:82199664 A/C cg09439754 chr16:82129088 HSD17B2 -0.37 -6.4 -0.37 6.93e-10 Lung adenocarcinoma; CESC cis rs2243480 1.000 rs160648 chr7:65543384 C/A cg12463550 chr7:65579703 CRCP 0.65 5.11 0.3 6.05e-7 Diabetic kidney disease; CESC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.34 -5.07 -0.3 7.49e-7 Total body bone mineral density; CESC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg03264133 chr6:25882463 NA -0.62 -9.3 -0.5 5.29e-18 Blood metabolite levels; CESC trans rs11722228 0.522 rs77691548 chr4:10136115 T/G cg26043149 chr18:55253948 FECH 1.01 13.16 0.63 8.63e-31 Gout;Urate levels;Serum uric acid levels; CESC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.58 6.95 0.39 2.84e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1316952 0.831 rs74624536 chr12:124393076 T/G cg12597309 chr12:124393772 DNAH10 0.34 5.16 0.3 4.8e-7 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.61e-7 Life satisfaction; CESC cis rs6546550 0.901 rs6546559 chr2:70145833 G/A cg02498382 chr2:70120550 SNRNP27 -0.39 -6.82 -0.39 5.98e-11 Prevalent atrial fibrillation; CESC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg24399712 chr22:39784796 NA 0.83 11.48 0.58 5.08e-25 Intelligence (multi-trait analysis); CESC cis rs4803468 1.000 rs878083 chr19:41897688 G/A cg14132834 chr19:41945861 ATP5SL -0.6 -7.48 -0.42 1.07e-12 Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17274400 chr12:8234945 NECAP1 -0.52 -6.71 -0.38 1.19e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4481887 0.962 rs4244177 chr1:248468279 C/T cg00666640 chr1:248458726 OR2T12 0.39 6.36 0.36 8.71e-10 Common traits (Other); CESC cis rs9325144 1.000 rs10506124 chr12:39019236 C/A cg26384229 chr12:38710491 ALG10B -0.47 -5.8 -0.34 1.87e-8 Morning vs. evening chronotype; CESC cis rs4808199 0.842 rs11085259 chr19:19445856 C/T cg03709012 chr19:19516395 GATAD2A 1.1 12.41 0.61 3.6e-28 Nonalcoholic fatty liver disease; CESC cis rs116095464 0.558 rs56342538 chr5:225796 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.72 -0.47 3.15e-16 Breast cancer; CESC cis rs524281 0.861 rs10896087 chr11:65924549 A/G cg14036092 chr11:66035641 RAB1B -0.56 -5.57 -0.32 6.24e-8 Electroencephalogram traits; CESC cis rs62229266 0.804 rs62230822 chr21:37429945 T/C cg12218747 chr21:37451666 NA -0.43 -6.01 -0.35 6.17e-9 Mitral valve prolapse; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg03388569 chr15:40426063 NA -0.37 -6.09 -0.35 3.89e-9 Thyroid stimulating hormone; CESC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg25036284 chr2:26402008 FAM59B 0.73 7.84 0.43 1.13e-13 Gut microbiome composition (summer); CESC cis rs709400 0.628 rs7155014 chr14:103863970 C/G cg12935359 chr14:103987150 CKB -0.52 -7.92 -0.44 6.43e-14 Body mass index; CESC cis rs60843830 0.623 rs55932737 chr2:107543 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.51 6.08 0.35 4.21e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs941207 0.542 rs11171979 chr12:57195983 C/G cg26462586 chr2:11164677 NA 0.4 6.6 0.38 2.25e-10 Platelet count; CESC cis rs765787 0.530 rs11636367 chr15:45535862 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.2 -0.4 6.34e-12 Uric acid levels; CESC cis rs703842 1.000 rs10747783 chr12:58176614 T/C cg18357645 chr12:58087776 OS9 -0.4 -5.62 -0.33 4.76e-8 Multiple sclerosis; CESC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg13607699 chr17:42295918 UBTF 0.56 7.21 0.41 5.79e-12 Total body bone mineral density; CESC cis rs950169 0.840 rs72748702 chr15:84915246 A/G cg17507749 chr15:85114479 UBE2QP1 0.56 6.28 0.36 1.4e-9 Schizophrenia; CESC cis rs3733585 0.598 rs28677023 chr4:9958326 C/A cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg07414643 chr4:187882934 NA 0.54 7.78 0.43 1.65e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg21984481 chr17:79567631 NPLOC4 0.49 7.98 0.44 4.42e-14 Eye color traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18492115 chr19:7528785 ARHGEF18 0.48 6.46 0.37 4.85e-10 Fibrinogen levels; CESC cis rs7267979 1.000 rs1077889 chr20:25267893 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.46 0.75 1.72e-49 Liver enzyme levels (alkaline phosphatase); CESC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.49 6.13 0.35 3.26e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3733585 0.699 rs6839490 chr4:9965000 C/G cg06891006 chr4:10084680 WDR1 0.42 5.55 0.32 6.92e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2204008 0.744 rs1115514 chr12:38280140 C/T cg26384229 chr12:38710491 ALG10B 0.65 9.03 0.49 3.55e-17 Bladder cancer; CESC cis rs936229 0.813 rs1350193 chr15:75084281 G/C cg14664628 chr15:75095509 CSK -0.91 -13.32 -0.63 2.5e-31 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg05255149 chr17:80675120 FN3KRP -0.45 -5.26 -0.31 2.99e-7 Breast cancer; CESC cis rs7965445 1.000 rs12423722 chr12:131866652 G/T cg06712767 chr12:131118561 NA 0.54 5.07 0.3 7.33e-7 Mortality in heart failure; CESC cis rs72945132 1.000 rs72945132 chr11:70113901 G/C cg00319359 chr11:70116639 PPFIA1 0.84 7.86 0.43 9.71e-14 Coronary artery disease; CESC cis rs888194 0.934 rs12314392 chr12:110010866 A/G cg19025524 chr12:109796872 NA -0.35 -5.13 -0.3 5.48e-7 Neuroticism; CESC cis rs6546550 0.901 rs4852375 chr2:70125988 C/G cg02498382 chr2:70120550 SNRNP27 -0.43 -7.41 -0.41 1.65e-12 Prevalent atrial fibrillation; CESC trans rs853679 0.546 rs71537572 chr6:27970715 T/C cg06606381 chr12:133084897 FBRSL1 -1.1 -8.82 -0.48 1.61e-16 Depression; CESC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg13628971 chr7:2884303 GNA12 0.61 7.92 0.44 6.39e-14 Height; CESC cis rs6568686 0.627 rs174387 chr6:111915023 C/T cg22127309 chr6:111907043 TRAF3IP2 0.53 5.36 0.31 1.82e-7 Depressive and manic episodes in bipolar disorder;Depressive episodes in bipolar disorder; CESC cis rs5769765 0.862 rs138856 chr22:50199378 G/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.48 -5.2 -0.3 4.02e-7 Schizophrenia; CESC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg06028808 chr11:68637592 NA 0.41 5.2 0.3 4.05e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8092503 1.000 rs12959833 chr18:52492579 A/G cg12377874 chr18:52495404 RAB27B -0.37 -5.96 -0.34 8.15e-9 Childhood body mass index; CESC cis rs6912958 0.781 rs3757368 chr6:88224495 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.11 -0.3 6.11e-7 Monocyte percentage of white cells; CESC cis rs17253792 0.915 rs76957332 chr14:56195370 G/A cg01858014 chr14:56050164 KTN1 -0.97 -7.52 -0.42 8.7e-13 Putamen volume; CESC cis rs8077577 0.747 rs11872031 chr17:18150814 G/A cg16794390 chr17:18148240 FLII 0.42 6.35 0.36 9.46e-10 Obesity-related traits; CESC cis rs992157 0.835 rs4674282 chr2:219144230 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.68 -8.89 -0.48 9.33e-17 Colorectal cancer; CESC cis rs2901656 0.640 rs9425316 chr1:172400860 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.56 8.63 0.47 5.87e-16 Red cell distribution width;Platelet distribution width; CESC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg11764359 chr7:65958608 NA 0.81 11.89 0.59 2.11e-26 Aortic root size; CESC cis rs950169 0.922 rs62029585 chr15:84951874 C/G cg17507749 chr15:85114479 UBE2QP1 0.58 6.2 0.36 2.15e-9 Schizophrenia; CESC cis rs3820068 0.603 rs72647128 chr1:15963908 T/C cg17385448 chr1:15911702 AGMAT 0.42 6.89 0.39 4.06e-11 Systolic blood pressure; CESC cis rs472402 0.560 rs2303705 chr5:6622017 A/C cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.48 -6.56 -0.37 2.77e-10 Response to amphetamines; CESC cis rs722599 0.748 rs11623342 chr14:75347937 A/C cg08847533 chr14:75593920 NEK9 -0.45 -5.36 -0.31 1.81e-7 IgG glycosylation; CESC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.73 9.65 0.51 4.32e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3741151 0.892 rs2027760 chr11:73036481 G/A cg17517138 chr11:73019481 ARHGEF17 0.61 5.21 0.3 3.89e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23635580 chr17:41476114 ARL4D -0.58 -7.09 -0.4 1.25e-11 Gut microbiome composition (summer); CESC cis rs10242455 0.867 rs2687142 chr7:99320570 A/G cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs208520 0.955 rs9345808 chr6:67008262 C/T cg07460842 chr6:66804631 NA 0.64 7.48 0.42 1.12e-12 Exhaled nitric oxide output; CESC cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg16405210 chr4:1374714 KIAA1530 -0.54 -6.68 -0.38 1.42e-10 Obesity-related traits; CESC cis rs1670533 1.000 rs7669622 chr4:1058659 A/G cg27284194 chr4:1044797 NA 0.49 6.18 0.35 2.44e-9 Recombination rate (females); CESC cis rs8049040 0.547 rs891131 chr16:71432417 G/A cg08717414 chr16:71523259 ZNF19 -0.61 -6.71 -0.38 1.19e-10 Blood protein levels; CESC cis rs4654899 1.000 rs6682368 chr1:21506914 G/A cg05370193 chr1:21551575 ECE1 0.41 6.22 0.36 1.96e-9 Superior frontal gyrus grey matter volume; CESC cis rs11235843 0.602 rs1830069 chr11:73433229 C/G cg18195628 chr11:73498948 MRPL48 -0.47 -5.15 -0.3 5.14e-7 Hand grip strength; CESC cis rs9811920 0.690 rs7623587 chr3:99906751 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 5.74 0.33 2.56e-8 Axial length; CESC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg13114125 chr14:105738426 BRF1 -0.75 -9.35 -0.5 3.93e-18 Mean platelet volume;Platelet distribution width; CESC cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg04455712 chr21:45112962 RRP1B 0.38 5.49 0.32 9.39e-8 Mean corpuscular volume; CESC cis rs10242455 0.702 rs79285548 chr7:99058396 T/C cg18809830 chr7:99032528 PTCD1 -0.85 -5.63 -0.33 4.58e-8 Blood metabolite levels; CESC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Depression; CESC cis rs2777491 0.957 rs7163788 chr15:41704789 A/G cg12386646 chr15:41787261 ITPKA 0.35 5.16 0.3 4.92e-7 Ulcerative colitis; CESC cis rs72781680 0.898 rs72798041 chr2:23953076 T/C cg08917208 chr2:24149416 ATAD2B 1.13 10.25 0.53 5.6e-21 Lymphocyte counts; CESC cis rs4664304 0.781 rs3828323 chr2:160808075 C/T cg03641300 chr2:160917029 PLA2R1 -0.41 -5.42 -0.32 1.35e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs453301 0.686 rs6987107 chr8:8893581 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -6.09 -0.35 3.89e-9 Joint mobility (Beighton score); CESC cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg10523679 chr1:76189770 ACADM -0.69 -7.9 -0.44 7.72e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs72627123 0.867 rs74635757 chr14:74489225 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.65 0.33 4.06e-8 Morning vs. evening chronotype; CESC cis rs193541 0.632 rs4835896 chr5:122121240 C/T cg19412675 chr5:122181750 SNX24 -0.43 -5.12 -0.3 5.97e-7 Glucose homeostasis traits; CESC cis rs6088580 0.634 rs1205336 chr20:32926336 G/A cg06115741 chr20:33292138 TP53INP2 -0.45 -5.69 -0.33 3.36e-8 Glomerular filtration rate (creatinine); CESC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg18337363 chr3:52569053 NT5DC2 0.28 5.03 0.3 9.16e-7 Bipolar disorder; CESC cis rs1707322 0.752 rs12047629 chr1:46162802 G/A cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg23281280 chr6:28129359 ZNF389 0.53 7.06 0.4 1.5e-11 Parkinson's disease; CESC cis rs1577917 1.000 rs1857964 chr6:86635994 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -5.94 -0.34 8.86e-9 Response to antipsychotic treatment; CESC cis rs12545109 0.800 rs1371936 chr8:57422715 A/G cg09654669 chr8:57350985 NA -0.55 -6.58 -0.37 2.56e-10 Obesity-related traits; CESC cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg25019033 chr10:957182 NA -0.57 -6.07 -0.35 4.31e-9 Eosinophil percentage of granulocytes; CESC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg05754148 chr16:3507555 NAT15 0.57 8.2 0.45 1.02e-14 Tuberculosis; CESC cis rs9527 0.544 rs3781280 chr10:104863843 T/G cg04362960 chr10:104952993 NT5C2 0.43 5.42 0.32 1.37e-7 Arsenic metabolism; CESC cis rs9814567 0.964 rs9820425 chr3:134223018 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.98 -0.35 7.05e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09806633 chr1:36689896 THRAP3 0.66 7.35 0.41 2.49e-12 Gut microbiome composition (summer); CESC cis rs11112613 0.595 rs871219 chr12:105938519 C/A cg03607813 chr12:105948248 NA 0.61 6.84 0.39 5.62e-11 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg05283184 chr6:79620031 NA -0.43 -6.61 -0.38 2.06e-10 Intelligence (multi-trait analysis); CESC cis rs9300255 0.639 rs1716171 chr12:123716376 C/T cg05973401 chr12:123451056 ABCB9 0.51 5.66 0.33 3.91e-8 Neutrophil percentage of white cells; CESC cis rs1691799 0.867 rs1168339 chr12:66759236 T/G cg16791601 chr12:66731901 HELB -0.79 -14.11 -0.65 4.25e-34 White blood cell count (basophil); CESC cis rs8040855 0.690 rs8041189 chr15:85686327 A/G cg08123816 chr15:85640762 PDE8A 0.41 5.76 0.33 2.38e-8 Bulimia nervosa; CESC cis rs11122272 0.701 rs2749702 chr1:231523808 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs870825 0.860 rs34985821 chr4:185599489 G/A cg04058563 chr4:185651563 MLF1IP 0.56 5.25 0.31 3.12e-7 Blood protein levels; CESC cis rs17433780 0.666 rs2624 chr1:89518623 C/T cg09516651 chr1:89888402 LOC400759 -0.66 -10.09 -0.53 1.81e-20 Carotid intima media thickness; CESC cis rs7662987 0.793 rs4699700 chr4:99998335 A/G cg13256891 chr4:100009986 ADH5 -0.59 -5.13 -0.3 5.71e-7 Smoking initiation; CESC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg05585544 chr11:47624801 NA 0.42 6.19 0.36 2.3e-9 Subjective well-being; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg13596910 chr17:42254336 C17orf65;ASB16 -0.54 -6.38 -0.36 7.84e-10 Psoriatic arthritis; CESC cis rs921968 0.584 rs2305833 chr2:219305404 G/C cg02176678 chr2:219576539 TTLL4 0.38 6.44 0.37 5.62e-10 Mean corpuscular hemoglobin concentration; CESC cis rs6540556 0.834 rs6700223 chr1:209935031 G/A cg05527609 chr1:210001259 C1orf107 -0.4 -5.11 -0.3 6.08e-7 Red blood cell count; CESC cis rs2204008 0.712 rs12371182 chr12:38321143 A/C cg26384229 chr12:38710491 ALG10B 0.73 10.34 0.54 2.85e-21 Bladder cancer; CESC cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg11952622 chr19:58962976 ZNF324B 0.49 6.7 0.38 1.22e-10 Uric acid clearance; CESC cis rs56399783 0.901 rs55767077 chr7:2774608 C/T cg19731401 chr7:2775893 GNA12 0.69 6.13 0.35 3.19e-9 Childhood ear infection; CESC cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs367943 0.666 rs10074214 chr5:112702214 A/G cg12552261 chr5:112820674 MCC 0.39 5.08 0.3 7.03e-7 Type 2 diabetes; CESC cis rs367943 0.698 rs7718310 chr5:112970628 A/G cg12552261 chr5:112820674 MCC 0.44 5.63 0.33 4.63e-8 Type 2 diabetes; CESC cis rs9916302 0.706 rs7503377 chr17:37708841 A/G cg00129232 chr17:37814104 STARD3 -0.56 -5.56 -0.32 6.57e-8 Glomerular filtration rate (creatinine); CESC cis rs3106136 0.546 rs2632417 chr4:95137542 G/C cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Capecitabine sensitivity; CESC cis rs4242434 0.927 rs746011 chr8:22457804 C/T cg03733263 chr8:22462867 KIAA1967 0.97 14.07 0.65 5.82e-34 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs829880 0.558 rs249820 chr12:98897473 A/G cg25150519 chr12:98850993 NA 0.51 5.97 0.34 7.65e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6089584 0.507 rs6061989 chr20:60627893 C/T cg06108461 chr20:60628389 TAF4 -0.61 -8.18 -0.45 1.16e-14 Body mass index; CESC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg23982607 chr1:1823379 GNB1 0.75 12.17 0.6 2.38e-27 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04902364 chr7:128696229 LOC286016;TNPO3 -0.64 -7.43 -0.42 1.5e-12 Gut microbiome composition (summer); CESC cis rs6580649 0.941 rs7957764 chr12:48429701 C/T cg24011408 chr12:48396354 COL2A1 -0.43 -5.35 -0.31 1.95e-7 Lung cancer; CESC cis rs459571 0.839 rs10993895 chr9:136887726 C/T cg13789015 chr9:136890014 NCRNA00094 -0.56 -8.08 -0.44 2.35e-14 Platelet distribution width; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02034563 chr2:179060011 OSBPL6 0.45 6.2 0.36 2.15e-9 Gut microbiota (bacterial taxa); CESC cis rs7584330 0.638 rs13429533 chr2:238448712 A/G cg14458575 chr2:238380390 NA 0.41 6.2 0.36 2.15e-9 Prostate cancer; CESC cis rs12477438 0.520 rs13030961 chr2:99799520 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.85 14.88 0.67 7.98e-37 Chronic sinus infection; CESC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg25767906 chr1:53392781 SCP2 -0.45 -5.76 -0.33 2.27e-8 Monocyte count; CESC trans rs7943203 1.000 rs1960006 chr11:108294107 A/G cg01416241 chr5:148737479 PCYOX1L -0.48 -6.24 -0.36 1.74e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs7267979 0.934 rs6037085 chr20:25305202 C/T cg08601574 chr20:25228251 PYGB -0.39 -5.7 -0.33 3.23e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg10053473 chr17:62856997 LRRC37A3 -0.7 -7.51 -0.42 9.29e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg09033563 chr22:24373618 LOC391322 -0.43 -5.67 -0.33 3.73e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg22431228 chr1:16359049 CLCNKA -0.5 -8.35 -0.46 3.76e-15 Dilated cardiomyopathy; CESC cis rs2011503 0.882 rs10407933 chr19:19364319 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.54 5.73 0.33 2.76e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21582780 chr11:59327931 NA -0.64 -7.9 -0.44 7.63e-14 Gut microbiome composition (summer); CESC cis rs6430585 0.528 rs309152 chr2:136657252 C/T cg07169764 chr2:136633963 MCM6 -0.96 -13.31 -0.63 2.63e-31 Corneal structure; CESC trans rs7937682 0.710 rs674230 chr11:111437887 A/G cg18187862 chr3:45730750 SACM1L 0.57 7.18 0.4 7.14e-12 Primary sclerosing cholangitis; CESC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg07870213 chr5:140052090 DND1 -0.62 -6.81 -0.39 6.5e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs28386778 0.965 rs2854154 chr17:61981696 C/A cg11494091 chr17:61959527 GH2 -0.79 -14.06 -0.65 6.61e-34 Prudent dietary pattern; CESC cis rs11997175 0.546 rs1561913 chr8:33587002 A/T ch.8.33884649F chr8:33765107 NA 0.56 7.31 0.41 3.18e-12 Body mass index; CESC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg11905131 chr22:24372483 LOC391322 -0.59 -6.94 -0.39 3.06e-11 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs3768617 0.510 rs1886501 chr1:183095234 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs1707322 0.890 rs2297883 chr1:46511487 G/C cg06784218 chr1:46089804 CCDC17 -0.33 -5.65 -0.33 4.08e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs644799 0.932 rs523934 chr11:95641775 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.65 8.52 0.46 1.24e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs477692 0.549 rs7079744 chr10:131454790 G/A cg05714579 chr10:131428358 MGMT -0.42 -5.63 -0.33 4.47e-8 Response to temozolomide; CESC cis rs4888262 0.545 rs8052923 chr16:74680105 C/T cg01733217 chr16:74700730 RFWD3 0.9 12.18 0.6 2.13e-27 Testicular germ cell tumor; CESC cis rs17376456 0.569 rs6881815 chr5:93105666 A/G cg25358565 chr5:93447407 FAM172A 0.68 7.25 0.41 4.53e-12 Diabetic retinopathy; CESC cis rs8114671 0.562 rs8116657 chr20:33476474 C/G cg07148914 chr20:33460835 GGT7 0.52 6.78 0.38 7.94e-11 Height; CESC cis rs3008870 0.958 rs34367328 chr1:67445321 T/C cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.19 -0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs2294693 0.945 rs9369255 chr6:40989503 T/C cg14769373 chr6:40998127 UNC5CL -0.48 -6.38 -0.36 7.9e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs7267979 0.816 rs6138593 chr20:25504492 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 14.8 0.67 1.56e-36 Liver enzyme levels (alkaline phosphatase); CESC trans rs9646096 0.558 rs1830656 chr13:38004096 C/G cg01311313 chr8:35252359 UNC5D -0.5 -6.32 -0.36 1.1e-9 Age-related macular degeneration; CESC cis rs939658 0.805 rs8036435 chr15:79420031 T/C cg17916960 chr15:79447300 NA -0.37 -6.1 -0.35 3.72e-9 Refractive error; CESC cis rs4604732 0.631 rs11490199 chr1:247625737 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs8028182 0.609 rs10220738 chr15:75666546 A/T cg20655648 chr15:75932815 IMP3 -0.45 -5.72 -0.33 2.86e-8 Sudden cardiac arrest; CESC cis rs9314323 0.862 rs7813520 chr8:26263260 C/T cg11498726 chr8:26250323 BNIP3L -0.44 -6.46 -0.37 4.91e-10 Red cell distribution width; CESC cis rs7107174 1.000 rs1006441 chr11:77932126 G/C cg02023728 chr11:77925099 USP35 0.49 6.28 0.36 1.41e-9 Testicular germ cell tumor; CESC cis rs12497850 0.931 rs7623023 chr3:48914238 G/A cg06212747 chr3:49208901 KLHDC8B 0.67 9.3 0.5 5.49e-18 Parkinson's disease; CESC cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.7 -0.43 2.64e-13 Alzheimer's disease; CESC cis rs7714584 1.000 rs10078968 chr5:150244273 C/A cg22134413 chr5:150180641 NA 0.49 5.7 0.33 3.1e-8 Crohn's disease; CESC cis rs798766 0.953 rs13123646 chr4:1740539 T/C cg10756475 chr4:1757242 NA 0.48 6.56 0.37 2.85e-10 Bladder cancer;Urinary bladder cancer; CESC cis rs5758659 0.729 rs134866 chr22:42650663 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.3 -5.25 -0.31 3.1e-7 Cognitive function; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06985640 chr6:89790434 PNRC1 -0.51 -6.5 -0.37 3.88e-10 Ulcerative colitis; CESC cis rs425277 1.000 rs385039 chr1:2077409 C/T cg04315214 chr1:2043799 PRKCZ 0.37 5.26 0.31 2.99e-7 Height; CESC cis rs7818382 1.000 rs7818382 chr8:96054000 C/T cg16049864 chr8:95962084 TP53INP1 -0.52 -8.53 -0.46 1.13e-15 Alzheimer's disease (late onset); CESC cis rs6570726 0.935 rs395948 chr6:145820185 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs734999 0.549 rs3828154 chr1:2524943 G/A cg20673091 chr1:2541236 MMEL1 0.43 7.25 0.41 4.49e-12 Ulcerative colitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02290708 chr21:35747831 FAM165B -0.44 -6.14 -0.35 2.99e-9 Gut microbiota (bacterial taxa); CESC cis rs9303542 0.559 rs56038617 chr17:46612578 C/T cg04904318 chr17:46607828 HOXB1 -0.6 -5.74 -0.33 2.54e-8 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg09658497 chr7:2847517 GNA12 -0.34 -5.09 -0.3 6.95e-7 Height; CESC cis rs62408225 1.000 rs905670 chr6:90958502 G/A cg06866423 chr6:90926672 BACH2 0.44 5.34 0.31 2.01e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7520050 0.933 rs4504835 chr1:46455571 G/A cg03146154 chr1:46216737 IPP -0.47 -6.06 -0.35 4.57e-9 Red blood cell count;Reticulocyte count; CESC trans rs1814175 0.765 rs1721990 chr11:49912154 G/C cg03929089 chr4:120376271 NA -0.93 -16.26 -0.71 1.03e-41 Height; CESC cis rs470119 0.966 rs140523 chr22:50962782 C/G cg12969734 chr22:50962224 SCO2 0.4 6.13 0.35 3.24e-9 Mean corpuscular hemoglobin; CESC cis rs71636778 0.543 rs34409791 chr1:27245363 A/G cg12203394 chr1:27248618 NUDC 0.66 5.55 0.32 6.85e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs3741151 1.000 rs75114310 chr11:73042047 C/T cg17517138 chr11:73019481 ARHGEF17 1.09 7.65 0.43 3.64e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs2342371 0.756 rs3973 chr3:196124278 A/G cg15048948 chr3:196158458 UBXN7 -0.53 -7.02 -0.4 1.85e-11 Fat distribution (HIV); CESC cis rs34779708 0.931 rs68039650 chr10:35385499 C/A cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg27170947 chr2:26402098 FAM59B -0.58 -6.85 -0.39 5.29e-11 Gut microbiome composition (summer); CESC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11122272 0.735 rs2491403 chr1:231511185 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs9837602 1.000 rs34626154 chr3:99756312 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.52 7.03 0.4 1.75e-11 Breast cancer; CESC cis rs7772486 0.806 rs2265477 chr6:146212338 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.45 0.37 5.3e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.14 0.4 9.2e-12 Bipolar disorder; CESC cis rs10504073 0.584 rs7820270 chr8:49971395 G/T cg00325661 chr8:49890786 NA 0.57 8.65 0.47 5.15e-16 Blood metabolite ratios; CESC cis rs9291683 0.609 rs55959894 chr4:10026580 G/A cg00071950 chr4:10020882 SLC2A9 0.89 16.34 0.71 5.44e-42 Bone mineral density; CESC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg18032046 chr6:28092343 ZSCAN16 0.56 6.45 0.37 5.16e-10 Depression; CESC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs10979 0.965 rs9376759 chr6:143886959 G/A cg25407410 chr6:143891975 LOC285740 -0.59 -8.84 -0.48 1.32e-16 Hypospadias; CESC cis rs2204008 0.744 rs11514358 chr12:38255526 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.26 0.53 5.3e-21 Bladder cancer; CESC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg26818010 chr10:134567672 INPP5A -0.9 -10.88 -0.56 4.78e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1707322 1.000 rs6675222 chr1:46326576 G/T cg05343316 chr1:45956843 TESK2 0.44 5.51 0.32 8.33e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.66 0.61 4.8e-29 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 1.000 rs2531729 chr17:56539890 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -6.94 -0.39 2.97e-11 Intelligence (multi-trait analysis); CESC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg19077165 chr18:44547161 KATNAL2 -0.54 -7.94 -0.44 5.81e-14 Personality dimensions; CESC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg17372223 chr3:52568218 NT5DC2 0.42 6.33 0.36 1.04e-9 Bipolar disorder; CESC cis rs3008870 1.000 rs912797 chr1:67413478 A/G cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC trans rs3780486 0.846 rs10813960 chr9:33180362 C/T cg20290983 chr6:43655470 MRPS18A 0.85 12.26 0.6 1.09e-27 IgG glycosylation; CESC cis rs113835537 0.529 rs80100524 chr11:66245936 C/T cg24851651 chr11:66362959 CCS 0.46 5.78 0.33 2.12e-8 Airway imaging phenotypes; CESC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg22974920 chr21:40686053 BRWD1 -0.42 -5.14 -0.3 5.31e-7 Cognitive function; CESC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.82 8.33 0.46 4.25e-15 Platelet count; CESC cis rs7949030 0.596 rs11231138 chr11:62316195 C/G cg22862634 chr11:62369728 EML3;MTA2 0.59 8.11 0.45 1.89e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg24110177 chr3:50126178 RBM5 -0.56 -7.77 -0.43 1.72e-13 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23837253 chr19:47759802 CCDC9 -0.45 -6.46 -0.37 5.11e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4523957 0.583 rs2984942 chr17:2030155 A/G cg16513277 chr17:2031491 SMG6 -0.77 -11.25 -0.57 2.98e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11997175 0.756 rs4739435 chr8:33818818 A/G ch.8.33884649F chr8:33765107 NA 0.66 9.06 0.49 3.03e-17 Body mass index; CESC cis rs17376456 0.690 rs6892055 chr5:93113023 A/T cg21475434 chr5:93447410 FAM172A 0.8 7.15 0.4 8.45e-12 Diabetic retinopathy; CESC cis rs589448 0.967 rs634512 chr12:69754012 C/T cg22834771 chr12:69754056 YEATS4 -0.55 -7.29 -0.41 3.67e-12 Cerebrospinal fluid biomarker levels; CESC cis rs2243480 1.000 rs160655 chr7:65533214 T/C cg12463550 chr7:65579703 CRCP 0.65 5.08 0.3 7.08e-7 Diabetic kidney disease; CESC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg22535103 chr8:58192502 C8orf71 -1.04 -13.21 -0.63 5.76e-31 Developmental language disorder (linguistic errors); CESC cis rs16854884 0.657 rs16854819 chr3:143736126 C/T cg06585982 chr3:143692056 C3orf58 -0.51 -6.76 -0.38 8.98e-11 Economic and political preferences (feminism/equality); CESC trans rs9325144 0.600 rs12227663 chr12:38734922 C/T cg23762105 chr12:34175262 ALG10 0.48 6.23 0.36 1.81e-9 Morning vs. evening chronotype; CESC cis rs4891159 0.548 rs12454625 chr18:74128751 A/G cg24786174 chr18:74118243 ZNF516 0.84 15.96 0.7 1.24e-40 Longevity; CESC cis rs8050907 0.590 rs10500325 chr16:4553192 A/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.81 5.25 0.31 3.13e-7 Obesity-related traits; CESC cis rs501120 1.000 rs504799 chr10:44753456 C/T cg09554077 chr10:44749378 NA 0.52 6.89 0.39 3.96e-11 Coronary artery disease;Coronary heart disease; CESC cis rs7772486 0.846 rs7755440 chr6:146375906 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.41 0.37 6.45e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg17372223 chr3:52568218 NT5DC2 0.43 6.31 0.36 1.19e-9 Bipolar disorder; CESC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.61 -0.33 4.97e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09676606 chr12:102132872 SYCP3 -0.63 -6.85 -0.39 5.27e-11 Gut microbiome composition (summer); CESC cis rs7829975 0.840 rs555617 chr8:8592845 C/G cg18904891 chr8:8559673 CLDN23 -0.42 -5.12 -0.3 5.84e-7 Mood instability; CESC cis rs2019216 0.542 rs8073228 chr17:21909838 C/G cg22648282 chr17:21454238 C17orf51 -0.46 -6.12 -0.35 3.38e-9 Pelvic organ prolapse; CESC cis rs6973256 0.605 rs7794168 chr7:133357606 T/C cg10665199 chr7:133106180 EXOC4 0.46 6.29 0.36 1.28e-9 Intelligence (multi-trait analysis); CESC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.03 -0.35 5.41e-9 Developmental language disorder (linguistic errors); CESC trans rs11098499 0.909 rs28714195 chr4:120316950 A/T cg25214090 chr10:38739885 LOC399744 0.69 9.38 0.5 3.13e-18 Corneal astigmatism; CESC cis rs2637266 0.783 rs2395436 chr10:78488513 G/T cg18941641 chr10:78392320 NA 0.45 8.7 0.47 3.5e-16 Pulmonary function; CESC cis rs9915657 0.870 rs35271702 chr17:70140516 G/A cg06234051 chr17:70120541 SOX9 -0.45 -6.56 -0.37 2.8e-10 Thyroid hormone levels; CESC cis rs4523957 0.583 rs9889861 chr17:2041369 A/G cg16513277 chr17:2031491 SMG6 -0.79 -11.73 -0.58 6.95e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs948562 0.744 rs74406537 chr11:58220360 G/A cg24637035 chr12:120445227 CCDC64 -0.5 -6.06 -0.35 4.67e-9 Lymphoma; CESC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg18512352 chr11:47633146 NA 0.54 8.0 0.44 3.78e-14 Subjective well-being; CESC cis rs7586879 0.616 rs10206196 chr2:25137323 T/C cg01884057 chr2:25150051 NA 0.4 7.71 0.43 2.62e-13 Body mass index; CESC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg17971929 chr21:40555470 PSMG1 1.06 16.27 0.71 9.28e-42 Cognitive function; CESC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg03188948 chr7:1209495 NA 0.53 5.98 0.35 7.04e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6502050 0.799 rs7212023 chr17:80170354 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.25 -0.31 3.06e-7 Life satisfaction; CESC cis rs644799 0.544 rs1622515 chr11:95523433 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.59 7.98 0.44 4.44e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs722599 0.748 rs20578 chr14:75367807 C/T cg11812906 chr14:75593930 NEK9 -0.47 -5.69 -0.33 3.32e-8 IgG glycosylation; CESC cis rs1144333 0.850 rs1251273 chr1:76288617 A/G cg10523679 chr1:76189770 ACADM -0.56 -5.28 -0.31 2.65e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs8114671 0.562 rs1060615 chr20:33478381 C/T cg24642439 chr20:33292090 TP53INP2 -0.44 -5.41 -0.32 1.44e-7 Height; CESC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg26314531 chr2:26401878 FAM59B -0.83 -9.29 -0.5 5.94e-18 Gut microbiome composition (summer); CESC cis rs2228479 0.681 rs11642428 chr16:89971909 A/T cg04013166 chr16:89971882 TCF25 0.71 8.49 0.46 1.48e-15 Skin colour saturation; CESC cis rs763014 0.898 rs1045277 chr16:633125 T/C cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC cis rs2066819 1.000 rs871130 chr12:56648777 A/G cg26734620 chr12:56694298 CS -1.04 -6.73 -0.38 1.06e-10 Psoriasis vulgaris; CESC cis rs17431357 0.881 rs73230303 chr12:120980289 T/C cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg18337363 chr3:52569053 NT5DC2 0.34 6.6 0.38 2.29e-10 Electroencephalogram traits; CESC cis rs936229 0.784 rs12906946 chr15:75153140 A/G cg14664628 chr15:75095509 CSK -0.75 -9.19 -0.49 1.21e-17 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg26769984 chr7:1090371 C7orf50 -0.65 -7.66 -0.43 3.44e-13 Bronchopulmonary dysplasia; CESC cis rs67478160 0.643 rs6575997 chr14:104228546 C/T cg08213375 chr14:104286397 PPP1R13B -0.51 -10.29 -0.53 3.98e-21 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02758053 chr19:56165495 U2AF2 0.6 6.63 0.38 1.92e-10 Gut microbiome composition (summer); CESC cis rs1144713 0.531 rs2683491 chr12:32250865 A/T cg01321189 chr12:32259338 BICD1 0.45 5.8 0.34 1.84e-8 Obesity-related traits; CESC cis rs62229266 0.804 rs11088331 chr21:37421872 T/C cg08632701 chr21:37451849 NA -0.37 -5.2 -0.3 3.98e-7 Mitral valve prolapse; CESC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg24642844 chr7:1081250 C7orf50 -0.82 -9.97 -0.52 4.47e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1348850 0.567 rs1405714 chr2:178538584 A/G cg22681709 chr2:178499509 PDE11A 0.55 8.72 0.47 3.16e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.74 0.47 2.74e-16 Colonoscopy-negative controls vs population controls; CESC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg18765753 chr7:1198926 ZFAND2A -0.35 -5.13 -0.3 5.55e-7 Longevity;Endometriosis; CESC cis rs4737010 0.536 rs6474365 chr8:41662940 G/T cg08923054 chr8:41654455 ANK1 0.61 7.59 0.42 5.37e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg13206674 chr6:150067644 NUP43 0.45 6.49 0.37 4.24e-10 Lung cancer; CESC cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg24324837 chr19:49891574 CCDC155 0.54 6.33 0.36 1.02e-9 Multiple sclerosis; CESC cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg24110177 chr3:50126178 RBM5 -0.53 -7.23 -0.41 5.13e-12 Intelligence (multi-trait analysis); CESC cis rs9796 0.689 rs9888710 chr15:41446153 G/C cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.85 -0.39 5.07e-11 Menopause (age at onset); CESC cis rs34779708 0.931 rs1926554 chr10:35344969 C/T cg04310649 chr10:35416472 CREM -0.49 -5.87 -0.34 1.31e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs2430307 0.556 rs3930019 chr7:76541610 C/T cg15770687 chr7:76625569 PMS2L11 0.6 5.9 0.34 1.13e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC trans rs3741489 1.000 rs4758889 chr12:133475533 C/T cg24132527 chr5:140019269 TMCO6 1.1 7.39 0.41 1.91e-12 Cognitive function; CESC cis rs9814567 0.964 rs4539979 chr3:134287597 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.74 -0.33 2.62e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg00033643 chr7:134001901 SLC35B4 0.41 5.32 0.31 2.2e-7 Mean platelet volume; CESC trans rs12429889 0.831 rs6562808 chr13:74745973 T/C cg03455107 chr17:54509207 ANKFN1 0.36 6.23 0.36 1.87e-9 Sudden cardiac arrest; CESC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg04369109 chr6:150039330 LATS1 -0.38 -5.31 -0.31 2.29e-7 Lung cancer; CESC cis rs4979906 1.000 rs12264636 chr10:79448539 C/G cg07817648 chr10:79422355 NA 0.6 6.34 0.36 1.01e-9 Mortality in heart failure; CESC cis rs2645694 0.626 rs2703140 chr4:77830057 C/G cg18351406 chr4:77819688 ANKRD56 0.53 6.34 0.36 9.71e-10 Emphysema distribution in smoking; CESC cis rs2235544 0.565 rs665421 chr1:54469883 T/C cg25741118 chr1:54482237 LDLRAD1 0.24 5.76 0.33 2.29e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs2733201 1.000 rs2615285 chr15:44417376 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs523522 0.923 rs2235217 chr12:120884328 C/T cg12219531 chr12:120966889 COQ5 0.71 8.97 0.48 5.62e-17 High light scatter reticulocyte count; CESC cis rs11690935 0.655 rs17614941 chr2:172541378 A/G cg13550731 chr2:172543902 DYNC1I2 0.56 8.36 0.46 3.61e-15 Schizophrenia; CESC cis rs9300255 0.739 rs2337934 chr12:123745359 A/G cg05973401 chr12:123451056 ABCB9 0.5 5.68 0.33 3.53e-8 Neutrophil percentage of white cells; CESC cis rs1044826 0.619 rs6439856 chr3:139134868 A/T cg00490450 chr3:139108681 COPB2 -0.41 -5.04 -0.3 8.46e-7 Obesity-related traits; CESC cis rs9905704 0.918 rs12952362 chr17:56900870 A/G cg12560992 chr17:57184187 TRIM37 0.61 7.05 0.4 1.54e-11 Testicular germ cell tumor; CESC cis rs4851870 1.000 rs13025634 chr2:106440678 C/T cg16077055 chr2:106428750 NCK2 -0.39 -5.12 -0.3 5.84e-7 Addiction; CESC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs7647973 1.000 rs1982861 chr3:49577665 A/G cg02487422 chr3:49467188 NICN1 0.41 5.33 0.31 2.06e-7 Menarche (age at onset); CESC cis rs67311347 0.866 rs2371183 chr3:40334247 C/T cg24209194 chr3:40518798 ZNF619 -0.42 -5.46 -0.32 1.12e-7 Renal cell carcinoma; CESC cis rs6701037 1.000 rs6701037 chr1:175120079 G/T cg00321850 chr1:175162397 KIAA0040 0.4 5.51 0.32 8.33e-8 Alcohol dependence; CESC cis rs11690935 0.959 rs6709156 chr2:172591944 T/C cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.93 -0.68 5.55e-37 Schizophrenia; CESC cis rs6061231 0.505 rs13037253 chr20:60928724 G/A cg22633769 chr20:60982531 CABLES2 0.6 6.28 0.36 1.39e-9 Colorectal cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09854775 chr9:137029881 RNU6ATAC 0.48 6.1 0.35 3.82e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1707322 0.752 rs11211147 chr1:46110094 A/G cg06784218 chr1:46089804 CCDC17 0.4 7.04 0.4 1.69e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2980436 1 rs2980436 chr8:8092025 A/G cg06636001 chr8:8085503 FLJ10661 -0.6 -7.28 -0.41 3.85e-12 Schizophrenia; CESC cis rs2073300 1.000 rs6137976 chr20:23463241 C/T cg12062639 chr20:23401060 NAPB 0.92 6.06 0.35 4.62e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2251381 0.750 rs8129616 chr21:30520085 C/T cg24692254 chr21:30365293 RNF160 -0.79 -10.84 -0.55 6.83e-23 Selective IgA deficiency; CESC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.44 -5.04 -0.3 8.66e-7 Breast cancer; CESC cis rs7772486 0.686 rs7744014 chr6:146123818 G/A cg05347473 chr6:146136440 FBXO30 0.52 6.84 0.39 5.37e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2929278 0.617 rs11070410 chr15:44057045 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -7.71 -0.43 2.5e-13 Schizophrenia; CESC cis rs9291683 0.588 rs3756236 chr4:10013463 T/A cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.5e-12 Bone mineral density; CESC cis rs732765 0.648 rs8019391 chr14:75409682 T/C cg21190982 chr14:75180524 FCF1;KIAA0317 -0.38 -5.28 -0.31 2.64e-7 Non-small cell lung cancer; CESC cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg12756686 chr19:29218302 NA 0.42 5.84 0.34 1.56e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg00934597 chr7:893267 UNC84A 0.48 6.55 0.37 3.04e-10 Perceived unattractiveness to mosquitoes; CESC cis rs1003719 0.614 rs1053808 chr21:38525356 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.56 -7.4 -0.41 1.78e-12 Eye color traits; CESC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.13 -0.3 5.56e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs3540 0.533 rs2256097 chr15:90971331 A/T cg22089800 chr15:90895588 ZNF774 0.63 8.39 0.46 2.99e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg14393609 chr7:65229607 NA -0.51 -6.93 -0.39 3.27e-11 Aortic root size; CESC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg04414720 chr1:150670196 GOLPH3L 0.45 5.96 0.34 8.13e-9 Melanoma; CESC cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg07636037 chr3:49044803 WDR6 0.6 7.17 0.4 7.33e-12 Menarche (age at onset); CESC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg03806693 chr22:41940476 POLR3H 1.19 14.03 0.65 7.9e-34 Vitiligo; CESC cis rs12497850 0.931 rs4974082 chr3:48999323 G/A cg03060546 chr3:49711283 APEH 0.52 6.49 0.37 4.27e-10 Parkinson's disease; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg27172057 chr12:64616385 C12orf66 -0.5 -6.41 -0.37 6.48e-10 Height; CESC cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg08885076 chr2:99613938 TSGA10 -0.38 -5.06 -0.3 7.82e-7 Chronic sinus infection; CESC cis rs763121 0.853 rs8138996 chr22:39047435 G/T cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC trans rs11098499 0.569 rs10023641 chr4:120258410 C/G cg25214090 chr10:38739885 LOC399744 0.61 8.64 0.47 5.37e-16 Corneal astigmatism; CESC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC trans rs1557351 0.723 rs1893445 chr18:54722694 G/A cg11433624 chr6:7146702 RREB1 0.38 6.14 0.35 2.94e-9 Multiple sclerosis (age of onset); CESC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg03806693 chr22:41940476 POLR3H -1.19 -14.84 -0.67 1.11e-36 Vitiligo; CESC cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg23711669 chr6:146136114 FBXO30 0.98 14.9 0.68 6.68e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg12193833 chr17:30244370 NA 0.54 5.5 0.32 9.16e-8 Hip circumference adjusted for BMI; CESC cis rs17539620 0.624 rs62432737 chr6:154834772 G/A cg17771515 chr6:154831774 CNKSR3 0.58 5.79 0.34 1.98e-8 Lipoprotein (a) levels; CESC cis rs10751667 0.666 rs7944815 chr11:959776 C/T cg20946044 chr11:1010712 AP2A2 -0.38 -5.28 -0.31 2.65e-7 Alzheimer's disease (late onset); CESC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.66 -7.36 -0.41 2.36e-12 Gut microbiome composition (summer); CESC cis rs708547 0.874 rs73242624 chr4:57847420 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.59 -6.0 -0.35 6.48e-9 Response to bleomycin (chromatid breaks); CESC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg03806693 chr22:41940476 POLR3H -1.18 -14.86 -0.67 9.94e-37 Vitiligo; CESC cis rs7216064 0.532 rs8065296 chr17:66018562 T/A cg07042672 chr17:66097459 LOC651250 0.61 7.95 0.44 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg00071950 chr4:10020882 SLC2A9 -0.67 -10.43 -0.54 1.42e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg22535103 chr8:58192502 C8orf71 -1.06 -13.35 -0.63 2.01e-31 Developmental language disorder (linguistic errors); CESC trans rs9329221 0.572 rs4841295 chr8:10105115 C/T cg15556689 chr8:8085844 FLJ10661 0.56 6.82 0.39 6e-11 Neuroticism; CESC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg18876405 chr7:65276391 NA -0.51 -5.96 -0.34 8.21e-9 Aortic root size; CESC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -6.84 -0.39 5.46e-11 Schizophrenia, schizoaffective disorder or bipolar disorder; CESC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.06 12.34 0.6 5.85e-28 Gut microbiome composition (summer); CESC cis rs8103278 0.507 rs62111759 chr19:46296230 A/T cg11657440 chr19:46296263 DMWD 0.85 13.25 0.63 4.38e-31 Coronary artery disease; CESC cis rs9287719 0.967 rs10167129 chr2:10758575 G/A cg02196655 chr2:10830764 NOL10 -0.37 -5.67 -0.33 3.73e-8 Prostate cancer; CESC trans rs10203140 0.893 rs2355192 chr2:52261494 A/G ch.9.14534598R chr9:14544598 NA 0.58 6.03 0.35 5.35e-9 Exploratory eye movement dysfunction in schizophrenia (number of eye fixations); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01811378 chr1:120611586 NOTCH2 -0.43 -6.02 -0.35 5.72e-9 Fibrinogen levels; CESC cis rs9894429 1.000 rs4074915 chr17:79579230 G/A cg18240062 chr17:79603768 NPLOC4 -0.72 -10.27 -0.53 4.82e-21 Eye color traits; CESC cis rs634534 0.562 rs642293 chr11:65730217 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.74 10.78 0.55 1.02e-22 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs910316 0.967 rs8013444 chr14:75661981 A/G cg16144293 chr14:75469539 EIF2B2 0.41 5.31 0.31 2.3e-7 Height; CESC cis rs250677 0.522 rs7702695 chr5:148402550 T/A cg18129178 chr5:148520854 ABLIM3 -0.48 -5.35 -0.31 1.89e-7 Breast cancer; CESC cis rs2130392 0.702 rs12108497 chr4:185571557 C/T cg21366198 chr4:185655624 MLF1IP -0.51 -6.76 -0.38 8.81e-11 Kawasaki disease; CESC cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg26818010 chr10:134567672 INPP5A -0.85 -10.62 -0.55 3.48e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg02725872 chr8:58115012 NA -0.38 -5.1 -0.3 6.54e-7 Developmental language disorder (linguistic errors); CESC trans rs3118233 1 rs3118233 chr16:68733646 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.71 -9.39 -0.5 2.78e-18 Red cell distribution width; CESC cis rs7843479 0.601 rs7220 chr8:21863290 G/A cg17168535 chr8:21777572 XPO7 0.72 11.14 0.56 6.59e-24 Mean corpuscular volume; CESC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg16743903 chr16:89593216 SPG7 -0.44 -5.63 -0.33 4.7e-8 Multiple myeloma (IgH translocation); CESC cis rs4234798 0.500 rs34694340 chr4:7221424 A/C cg18431297 chr4:7219810 SORCS2 0.6 10.15 0.53 1.15e-20 Insulin-like growth factors; CESC cis rs72781680 0.898 rs17462433 chr2:24012758 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg18758796 chr5:131593413 PDLIM4 -0.46 -6.43 -0.37 5.87e-10 Breast cancer; CESC trans rs7335046 1.000 rs7322759 chr13:99909678 C/G cg14259717 chr11:18433732 LDHC 0.6 6.06 0.35 4.74e-9 Basal cell carcinoma; CESC cis rs713587 0.571 rs2438679 chr2:25317653 C/T cg01884057 chr2:25150051 NA -0.3 -5.2 -0.3 3.95e-7 Body mass index in non-asthmatics; CESC cis rs62344088 0.590 rs58563514 chr5:177837 C/T cg22857025 chr5:266934 NA -1.1 -8.56 -0.47 9.31e-16 Asthma (childhood onset); CESC cis rs524023 0.957 rs528211 chr11:64351721 C/T cg07220939 chr11:64358617 SLC22A12 0.34 5.24 0.31 3.3e-7 Urate levels in obese individuals; CESC cis rs7264396 0.733 rs6058305 chr20:34310757 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.58 0.42 5.71e-13 Total cholesterol levels; CESC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg13902645 chr11:5959945 NA 0.68 10.41 0.54 1.68e-21 DNA methylation (variation); CESC cis rs11031096 0.711 rs4910891 chr11:4153408 A/G cg18678763 chr11:4115507 RRM1 -0.46 -6.31 -0.36 1.19e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs290268 0.838 rs290993 chr9:93559572 G/A cg02608019 chr9:93564028 SYK 0.67 10.21 0.53 7.53e-21 Platelet count; CESC cis rs72945132 0.882 rs56770826 chr11:70128874 A/G cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.99 -0.35 6.73e-9 Total body bone mineral density; CESC cis rs9640161 0.636 rs3735171 chr7:150033882 A/G cg21361702 chr7:150065534 REPIN1 0.51 5.53 0.32 7.51e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg21138405 chr5:131827807 IRF1 0.54 9.32 0.5 4.74e-18 Asthma (sex interaction); CESC cis rs6696846 0.749 rs61822566 chr1:205078660 T/C cg00857998 chr1:205179979 DSTYK 0.51 6.96 0.39 2.6e-11 Red blood cell count; CESC trans rs6991952 0.845 rs7822766 chr8:25742279 A/T cg04738309 chr5:111093624 C5orf13 -0.49 -6.02 -0.35 5.8e-9 Inguinal hernia; CESC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg24531977 chr5:56204891 C5orf35 -0.48 -6.0 -0.35 6.53e-9 Coronary artery disease; CESC cis rs7772486 0.743 rs9403742 chr6:146060193 A/C cg23711669 chr6:146136114 FBXO30 0.84 12.33 0.6 6.55e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7940866 0.740 rs7131121 chr11:130806424 A/G cg12179176 chr11:130786555 SNX19 0.66 10.11 0.53 1.6e-20 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00945735 chr7:41982767 NA 0.58 6.62 0.38 2.03e-10 Gut microbiome composition (summer); CESC cis rs8077577 0.671 rs9909104 chr17:18248021 T/C cg16794390 chr17:18148240 FLII 0.38 6.2 0.36 2.19e-9 Obesity-related traits; CESC cis rs6963495 0.818 rs73192126 chr7:105175415 T/C cg02135003 chr7:105160482 PUS7 -0.46 -5.45 -0.32 1.13e-7 Bipolar disorder (body mass index interaction); CESC cis rs7561273 0.586 rs11896092 chr2:24317827 G/A cg20701182 chr2:24300061 SF3B14 0.52 6.63 0.38 1.89e-10 Quantitative traits; CESC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg24829409 chr8:58192753 C8orf71 -0.57 -7.07 -0.4 1.33e-11 Developmental language disorder (linguistic errors); CESC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg13902645 chr11:5959945 NA -0.65 -7.8 -0.43 1.39e-13 DNA methylation (variation); CESC cis rs10791097 0.720 rs6590518 chr11:130733530 C/T cg12179176 chr11:130786555 SNX19 0.65 9.77 0.51 1.9e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs861020 0.630 rs628445 chr1:210004953 C/T cg05527609 chr1:210001259 C1orf107 0.74 9.67 0.51 3.97e-19 Orofacial clefts; CESC trans rs6089829 0.925 rs2277767 chr20:61666937 G/A cg23505145 chr19:12996616 KLF1 0.52 6.8 0.39 6.85e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -6.78 -0.38 7.81e-11 Bipolar disorder; CESC cis rs6121246 0.559 rs1484994 chr20:30305975 A/G cg13852791 chr20:30311386 BCL2L1 0.86 11.09 0.56 9.96e-24 Mean corpuscular hemoglobin; CESC trans rs877282 0.945 rs11253398 chr10:790012 T/C cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs7927771 0.524 rs7123952 chr11:47852057 T/C cg20307385 chr11:47447363 PSMC3 0.62 8.66 0.47 4.58e-16 Subjective well-being; CESC cis rs12497850 1.000 rs1352420 chr3:48757291 A/G cg03060546 chr3:49711283 APEH 0.46 5.73 0.33 2.76e-8 Parkinson's disease; CESC trans rs4716602 0.596 rs12386634 chr7:156158373 G/A cg07175507 chr18:77160758 NFATC1 -0.44 -6.01 -0.35 6.12e-9 Anti-saccade response; CESC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg22968622 chr17:43663579 NA 1.31 17.87 0.74 2.04e-47 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7116495 1.000 rs7127865 chr11:71747781 G/C cg10381502 chr11:71823885 C11orf51 -0.68 -5.65 -0.33 4.05e-8 Severe influenza A (H1N1) infection; CESC cis rs10206020 0.885 rs11899557 chr2:1576123 G/T cg26248373 chr2:1572462 NA -0.59 -6.93 -0.39 3.22e-11 IgG glycosylation; CESC cis rs10979 0.965 rs34373782 chr6:143888258 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs2016266 0.859 rs7953656 chr12:53738433 G/T cg26875137 chr12:53738046 NA 0.36 5.24 0.31 3.23e-7 Bone mineral density (spine);Bone mineral density; CESC cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg10556349 chr10:835070 NA 0.62 5.91 0.34 1.04e-8 Eosinophil percentage of granulocytes; CESC cis rs2933343 0.700 rs1683777 chr3:128624880 T/G cg25356066 chr3:128598488 ACAD9 0.58 7.92 0.44 6.51e-14 IgG glycosylation; CESC cis rs6439153 0.933 rs6799008 chr3:128717387 G/T cg24203234 chr3:128598194 ACAD9 0.42 5.48 0.32 9.9e-8 Pneumococcal bacteremia; CESC cis rs8002861 0.846 rs12428112 chr13:44475821 C/A cg14210620 chr13:44453864 C13orf31;CCDC122 -0.42 -5.39 -0.31 1.58e-7 Leprosy; CESC trans rs1545843 0.564 rs2255396 chr12:84890315 G/T cg03015433 chr16:56623111 MT3 0.33 6.01 0.35 6.09e-9 Major depressive disorder; CESC cis rs9300255 0.602 rs1727314 chr12:123640664 C/A cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.16e-16 Neutrophil percentage of white cells; CESC cis rs7666738 0.546 rs34621463 chr4:98793357 G/C cg17366294 chr4:99064904 C4orf37 0.52 6.61 0.38 2.09e-10 Colonoscopy-negative controls vs population controls; CESC cis rs6710529 1 rs6710529 chr2:219645553 G/A cg02176678 chr2:219576539 TTLL4 -0.43 -7.5 -0.42 9.95e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7107174 1.000 rs7101429 chr11:77992967 A/G cg02023728 chr11:77925099 USP35 0.46 6.05 0.35 4.83e-9 Testicular germ cell tumor; CESC trans rs7760535 0.656 rs7766190 chr6:111905066 A/G ch.3.1021608R chr3:48511432 SHISA5 0.45 6.18 0.35 2.47e-9 Metabolic traits; CESC cis rs4253772 0.938 rs9626814 chr22:46637254 C/T cg00784671 chr22:46762841 CELSR1 -0.41 -5.6 -0.33 5.35e-8 LDL cholesterol;Cholesterol, total; CESC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg16606324 chr3:10149918 C3orf24 -0.42 -5.25 -0.31 3.14e-7 Alzheimer's disease; CESC cis rs151234 0.565 rs11401 chr16:28602991 A/G cg01378222 chr16:28622494 SULT1A1 -0.5 -7.64 -0.42 4e-13 Platelet distribution width; CESC cis rs9457247 1.000 rs1794693 chr6:167405670 T/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.54 -0.46 1.09e-15 Crohn's disease; CESC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -7.32 -0.41 2.98e-12 Alzheimer's disease; CESC cis rs73206853 0.764 rs67715513 chr12:110562910 G/A cg12870014 chr12:110450643 ANKRD13A 0.65 5.62 0.33 4.77e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9911578 0.967 rs302842 chr17:56728102 C/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC cis rs10191773 0.589 rs72831641 chr2:112955815 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.67 -6.61 -0.38 2.05e-10 Yeast infection; CESC cis rs9486719 0.948 rs11152952 chr6:96894303 A/G cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs3733585 0.673 rs7672947 chr4:9961368 G/C cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg07211511 chr3:129823064 LOC729375 -0.59 -7.28 -0.41 3.84e-12 Blood pressure (smoking interaction); CESC cis rs9457247 1.000 rs407515 chr6:167407544 G/C cg25258033 chr6:167368657 RNASET2 0.4 6.14 0.35 2.93e-9 Crohn's disease; CESC cis rs2880765 0.835 rs12910373 chr15:86046802 G/C cg10818794 chr15:86012489 AKAP13 -0.34 -5.22 -0.31 3.68e-7 Coronary artery disease; CESC cis rs67072384 0.818 rs2291293 chr11:72470653 C/T cg04827223 chr11:72435913 ARAP1 -0.65 -5.64 -0.33 4.42e-8 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs6964587 1.000 rs2075881 chr7:91734552 T/C cg17063962 chr7:91808500 NA 0.54 7.37 0.41 2.16e-12 Breast cancer; CESC cis rs524281 0.773 rs10791861 chr11:66008470 G/A cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.38e-7 Electroencephalogram traits; CESC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg11644478 chr21:40555479 PSMG1 1.01 16.02 0.7 7.49e-41 Cognitive function; CESC cis rs6831352 0.918 rs13110764 chr4:100062466 C/T cg13256891 chr4:100009986 ADH5 -0.65 -7.06 -0.4 1.48e-11 Alcohol dependence; CESC cis rs6598955 0.724 rs12132137 chr1:26631243 C/T cg00852783 chr1:26633632 UBXN11 0.43 6.26 0.36 1.55e-9 Obesity-related traits; CESC cis rs7474896 0.559 rs10740949 chr10:37978435 A/G cg00409905 chr10:38381863 ZNF37A -0.46 -5.39 -0.31 1.59e-7 Obesity (extreme); CESC cis rs7909074 0.966 rs4948645 chr10:45391481 A/G cg05187965 chr10:45406764 TMEM72 -0.33 -5.31 -0.31 2.32e-7 Mean corpuscular volume; CESC cis rs9911578 0.967 rs72628392 chr17:56506160 A/G cg12560992 chr17:57184187 TRIM37 -0.9 -15.09 -0.68 1.52e-37 Intelligence (multi-trait analysis); CESC cis rs2204008 0.687 rs11181339 chr12:38322271 G/T cg26384229 chr12:38710491 ALG10B 0.57 8.17 0.45 1.26e-14 Bladder cancer; CESC cis rs738322 0.718 rs3761445 chr22:38595411 G/A cg17652424 chr22:38574118 PLA2G6 0.31 5.39 0.31 1.53e-7 Cutaneous nevi; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26439759 chr12:102514173 C12orf48 -0.55 -6.27 -0.36 1.42e-9 Gut microbiome composition (summer); CESC cis rs4790333 0.529 rs3101409 chr17:2258147 C/T cg02569219 chr17:2266849 SGSM2 0.39 5.15 0.3 5.02e-7 Proinsulin levels; CESC trans rs1908814 0.516 rs7825529 chr8:11794444 C/T cg15556689 chr8:8085844 FLJ10661 0.51 6.32 0.36 1.1e-9 Neuroticism; CESC cis rs4986172 0.700 rs71373536 chr17:43221808 G/A cg10701640 chr17:43249399 NA 0.42 6.33 0.36 1.06e-9 Height; CESC cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg21138405 chr5:131827807 IRF1 0.64 11.77 0.59 5.28e-26 Asthma (sex interaction); CESC cis rs9768139 0.566 rs729099 chr7:158114152 C/T cg24154853 chr7:158122151 PTPRN2 0.38 5.65 0.33 4.21e-8 Calcium levels; CESC cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg18850127 chr7:39170497 POU6F2 0.39 5.51 0.32 8.38e-8 IgG glycosylation; CESC cis rs35110281 0.720 rs162376 chr21:44926759 G/T cg01579765 chr21:45077557 HSF2BP 0.54 9.04 0.49 3.44e-17 Mean corpuscular volume; CESC cis rs644799 1.000 rs473148 chr11:95628606 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.59 7.42 0.41 1.61e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.31 -5.14 -0.3 5.46e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs4563143 0.675 rs56407818 chr19:29279379 G/A cg12756686 chr19:29218302 NA 0.59 7.5 0.42 9.53e-13 Methadone dose in opioid dependence; CESC cis rs2243480 1.000 rs316307 chr7:65570171 C/T cg25894440 chr7:65020034 NA -0.61 -5.04 -0.3 8.69e-7 Diabetic kidney disease; CESC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.26 -0.31 2.92e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg26441486 chr22:50317300 CRELD2 0.48 5.97 0.34 7.77e-9 Schizophrenia; CESC cis rs73019876 0.836 rs2666438 chr19:22144259 A/G cg11619707 chr19:22235551 ZNF257 -0.28 -5.21 -0.3 3.89e-7 Testicular germ cell tumor; CESC cis rs1670533 1.000 rs1670534 chr4:1087265 T/C cg27284194 chr4:1044797 NA 0.48 6.17 0.35 2.6e-9 Recombination rate (females); CESC cis rs8005677 1.000 rs1956881 chr14:23394069 A/C cg25600027 chr14:23388339 RBM23 -0.43 -5.31 -0.31 2.36e-7 Cognitive ability (multi-trait analysis); CESC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg18876405 chr7:65276391 NA 0.53 7.32 0.41 3.01e-12 Aortic root size; CESC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.4 -0.57 9.17e-25 Type 2 diabetes; CESC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg24531977 chr5:56204891 C5orf35 -0.56 -7.03 -0.4 1.71e-11 Coronary artery disease; CESC cis rs9291683 0.620 rs11722946 chr4:10125990 A/G cg11266682 chr4:10021025 SLC2A9 -0.48 -8.53 -0.46 1.18e-15 Bone mineral density; CESC cis rs9486715 1.000 rs7752277 chr6:97065131 C/T cg18709589 chr6:96969512 KIAA0776 -0.46 -6.58 -0.37 2.44e-10 Headache; CESC cis rs12973672 1.000 rs1052033 chr19:35770471 C/T cg12095397 chr19:35769544 USF2 0.54 7.35 0.41 2.49e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6691722 0.503 rs4140519 chr1:24708304 C/T cg18323236 chr1:24743029 NIPAL3 0.38 5.58 0.32 5.82e-8 Response to interferon beta in multiple sclerosis; CESC cis rs10743315 0.778 rs7399032 chr12:19371546 T/C cg02471346 chr12:19282374 PLEKHA5 -0.5 -5.31 -0.31 2.35e-7 Gut microbiota (bacterial taxa); CESC cis rs2243480 0.803 rs13224048 chr7:65993766 G/A cg12463550 chr7:65579703 CRCP 0.72 5.55 0.32 6.96e-8 Diabetic kidney disease; CESC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4790333 1.000 rs4790332 chr17:2262611 G/A cg02569219 chr17:2266849 SGSM2 0.47 6.24 0.36 1.71e-9 Proinsulin levels; CESC cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.49 -6.26 -0.36 1.5e-9 Tonsillectomy; CESC cis rs79387448 0.655 rs79091585 chr2:102917243 C/T cg09003973 chr2:102972529 NA 1.11 8.63 0.47 5.6e-16 Gut microbiota (bacterial taxa); CESC cis rs28489187 0.683 rs2892888 chr1:85866147 A/G cg16011679 chr1:85725395 C1orf52 -0.46 -5.5 -0.32 9.09e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4803455 0.565 rs1025497 chr19:41871254 A/G cg08477640 chr19:41863820 B9D2 0.5 7.3 0.41 3.44e-12 Migraine;Coronary artery disease; CESC cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg24308560 chr3:49941425 MST1R -0.55 -7.67 -0.43 3.37e-13 Body mass index; CESC cis rs3806843 0.735 rs2563306 chr5:140070017 C/T cg26395211 chr5:140044315 WDR55 0.47 5.94 0.34 9.08e-9 Depressive symptoms (multi-trait analysis); CESC cis rs694739 1.000 rs1783521 chr11:64106291 T/C cg02228329 chr11:64053129 BAD;GPR137 0.66 8.61 0.47 6.83e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg12718519 chr1:2058417 PRKCZ 0.26 5.62 0.33 4.81e-8 Height; CESC cis rs738322 0.967 rs133024 chr22:38574066 C/T cg25457927 chr22:38595422 NA 0.29 5.45 0.32 1.15e-7 Cutaneous nevi; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg09033563 chr22:24373618 LOC391322 -0.52 -7.05 -0.4 1.6e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9902453 0.765 rs2264302 chr17:28057095 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.76 -10.3 -0.53 3.95e-21 Coffee consumption (cups per day); CESC trans rs78579285 0.510 rs78759106 chr16:88788535 T/C cg15076811 chr1:11001038 NA 0.7 6.01 0.35 6.01e-9 Joint mobility (Beighton score); CESC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg26335602 chr6:28129616 ZNF389 0.41 5.57 0.32 6.18e-8 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01233736 chr2:223725624 ACSL3 0.69 8.2 0.45 1.03e-14 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg07153921 chr17:41440717 NA -0.42 -5.61 -0.33 4.96e-8 Menopause (age at onset); CESC trans rs8026198 0.568 rs2918460 chr15:42617644 A/G cg19625216 chr1:249132108 ZNF672 -0.72 -6.04 -0.35 5.32e-9 Fibrinogen levels; CESC cis rs4919694 0.572 rs12255989 chr10:104867206 C/T cg04362960 chr10:104952993 NT5C2 0.63 6.25 0.36 1.66e-9 Arsenic metabolism; CESC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.53 8.09 0.44 2.18e-14 Total body bone mineral density; CESC cis rs7178572 0.568 rs11854193 chr15:77458136 C/A cg22256960 chr15:77711686 NA -0.54 -6.83 -0.39 5.7e-11 Type 2 diabetes; CESC cis rs7249921 0.833 rs7255878 chr19:35667192 C/T cg15419183 chr19:35660584 FXYD5 0.53 8.27 0.45 6.42e-15 Platelet count; CESC cis rs9814567 0.702 rs9871226 chr3:134331466 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.1 -0.3 6.38e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9987353 0.544 rs2929470 chr8:9062490 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -6.14 -0.35 2.95e-9 Recombination measurement; CESC cis rs12586317 0.586 rs2295103 chr14:35515920 C/G cg16230307 chr14:35515116 FAM177A1 1.08 11.39 0.57 9.7e-25 Psoriasis; CESC cis rs10791323 0.572 rs4353292 chr11:133742656 A/G cg03690763 chr11:133734501 NA -0.32 -5.41 -0.32 1.41e-7 Childhood ear infection; CESC cis rs2274273 0.934 rs8021940 chr14:55719715 G/A cg04306507 chr14:55594613 LGALS3 0.29 5.83 0.34 1.65e-8 Protein biomarker; CESC cis rs116095464 0.867 rs10074958 chr5:230828 C/T cg10591111 chr5:226296 SDHA -0.51 -6.19 -0.36 2.28e-9 Breast cancer; CESC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg02034447 chr16:89574710 SPG7 0.51 6.43 0.37 5.91e-10 Multiple myeloma (IgH translocation); CESC cis rs644799 1.000 rs12291986 chr11:95523030 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 14.1 0.65 4.64e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg25427524 chr10:38739819 LOC399744 0.64 9.23 0.49 8.8e-18 Extrinsic epigenetic age acceleration; CESC cis rs9303401 0.659 rs62083436 chr17:57031742 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.99 12.38 0.61 4.28e-28 Cognitive test performance; CESC cis rs3892630 0.817 rs35408716 chr19:33187961 A/C cg22980127 chr19:33182716 NUDT19 1.02 11.58 0.58 2.23e-25 Red blood cell traits; CESC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg11644478 chr21:40555479 PSMG1 -0.56 -7.65 -0.43 3.72e-13 Menarche (age at onset); CESC cis rs919433 0.963 rs1366837 chr2:198160501 T/C cg03934865 chr2:198174659 NA -0.47 -7.07 -0.4 1.38e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs61931739 0.500 rs11053282 chr12:34561151 T/C cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs4803468 1.000 rs1473248 chr19:41923314 C/T cg14132834 chr19:41945861 ATP5SL 0.68 8.39 0.46 2.9e-15 Height; CESC cis rs9457247 0.663 rs2301436 chr6:167437988 C/T cg25258033 chr6:167368657 RNASET2 0.35 5.03 0.3 8.85e-7 Crohn's disease; CESC cis rs548181 0.611 rs1293672 chr11:125461034 A/G cg03464685 chr11:125439445 EI24 1.24 9.78 0.51 1.74e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs6964833 0.872 rs4717903 chr7:74068167 T/C cg07504079 chr7:72649617 NCF1B -0.55 -6.23 -0.36 1.79e-9 Menarche (age at onset); CESC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.47 0.37 4.83e-10 Prudent dietary pattern; CESC cis rs3796352 1.000 rs11707780 chr3:53084326 A/G cg15956490 chr3:53032818 SFMBT1 -0.54 -5.38 -0.31 1.61e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg04455712 chr21:45112962 RRP1B 0.4 6.21 0.36 2.07e-9 Mean corpuscular volume; CESC cis rs16858210 0.607 rs953419 chr3:183585883 C/T cg25686905 chr3:183603175 PARL 0.33 5.84 0.34 1.49e-8 Menopause (age at onset); CESC cis rs9948 1.000 rs2276654 chr2:97492479 G/A cg01990225 chr2:97406019 LMAN2L -0.75 -5.44 -0.32 1.24e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs7539542 0.556 rs10753928 chr1:202891045 A/C cg19681188 chr1:202830198 LOC148709 -0.41 -5.19 -0.3 4.09e-7 Mean platelet volume; CESC cis rs7551222 0.752 rs4951389 chr1:204475834 G/T cg20240347 chr1:204465584 NA -0.27 -5.43 -0.32 1.26e-7 Schizophrenia; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg06911843 chr21:38639729 DSCR3 -0.5 -6.72 -0.38 1.11e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1707322 1.000 rs11211204 chr1:46317864 A/G cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg05863683 chr7:1912471 MAD1L1 0.38 5.89 0.34 1.19e-8 Bipolar disorder and schizophrenia; CESC cis rs6502050 0.604 rs9897355 chr17:80078095 G/A cg11859384 chr17:80120422 CCDC57 0.38 5.16 0.3 4.82e-7 Life satisfaction; CESC cis rs561341 1.000 rs561341 chr17:30316385 T/G cg12193833 chr17:30244370 NA -0.7 -6.49 -0.37 4.19e-10 Hip circumference adjusted for BMI; CESC cis rs7772486 0.713 rs1986729 chr6:146194831 G/A cg05347473 chr6:146136440 FBXO30 0.6 7.63 0.42 4.27e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs17431357 1.000 rs117094839 chr12:120922159 G/T cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg24562669 chr7:97807699 LMTK2 0.49 7.19 0.4 6.8e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg13298116 chr11:62369859 EML3;MTA2 0.53 7.46 0.42 1.26e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs6076065 0.630 rs2424559 chr20:23430519 A/G cg11657817 chr20:23433608 CST11 0.48 7.81 0.43 1.32e-13 Facial morphology (factor 15, philtrum width); CESC cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg21226059 chr5:178986404 RUFY1 0.49 7.57 0.42 6.27e-13 Lung cancer; CESC cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg05340658 chr4:99064831 C4orf37 0.74 10.68 0.55 2.18e-22 Colonoscopy-negative controls vs population controls; CESC cis rs10276381 1.000 rs10281214 chr7:28185544 G/C cg23620719 chr7:28220237 JAZF1 0.74 7.95 0.44 5.56e-14 Crohn's disease; CESC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg18876405 chr7:65276391 NA 0.45 6.09 0.35 3.92e-9 Aortic root size; CESC cis rs5750830 0.594 rs5757648 chr22:39775156 G/A cg11247378 chr22:39784982 NA -0.51 -7.72 -0.43 2.36e-13 Intelligence (multi-trait analysis); CESC cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg21918786 chr6:109611834 NA -0.4 -6.1 -0.35 3.81e-9 Reticulocyte fraction of red cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20706768 chr7:55225183 EGFR 0.45 6.24 0.36 1.77e-9 Fibrinogen levels; CESC cis rs9300255 0.569 rs1790115 chr12:123620270 C/G cg00376283 chr12:123451042 ABCB9 0.71 8.69 0.47 3.84e-16 Neutrophil percentage of white cells; CESC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs4471313 1.000 rs1095095 chr1:170354049 T/C cg14876685 chr7:99177937 NA -0.41 -6.21 -0.36 2.03e-9 Waist-hip ratio; CESC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg20243544 chr17:37824526 PNMT -0.48 -6.07 -0.35 4.42e-9 Glomerular filtration rate (creatinine); CESC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg18230493 chr5:56204884 C5orf35 -0.73 -8.91 -0.48 8.16e-17 Initial pursuit acceleration; CESC cis rs1256061 0.603 rs1256038 chr14:64740739 T/C cg21174375 chr14:64681225 SYNE2 0.51 6.82 0.39 6.15e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18173830 chr6:4776623 CDYL 0.5 6.29 0.36 1.3e-9 Gut microbiota (bacterial taxa); CESC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.26 0.31 3e-7 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21883765 chr7:127032075 ZNF800 -0.53 -6.07 -0.35 4.44e-9 Gut microbiome composition (summer); CESC cis rs9291683 0.588 rs13113730 chr4:10017628 C/T cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.51e-12 Bone mineral density; CESC cis rs6499129 0.702 rs8044843 chr16:67318242 A/G cg26727032 chr16:67993705 SLC12A4 -0.52 -5.77 -0.33 2.19e-8 Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05909891 chr12:19565983 NA -0.66 -7.86 -0.43 9.7e-14 Gut microbiome composition (summer); CESC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg05863683 chr7:1912471 MAD1L1 0.36 5.34 0.31 1.99e-7 Bipolar disorder and schizophrenia; CESC cis rs698813 0.637 rs4952706 chr2:44500536 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.17 0.3 4.69e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs10504073 0.584 rs11776843 chr8:49928449 C/T cg00325661 chr8:49890786 NA 0.54 8.2 0.45 1.02e-14 Blood metabolite ratios; CESC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg04025307 chr7:1156635 C7orf50 0.41 5.09 0.3 6.95e-7 Bronchopulmonary dysplasia; CESC cis rs2404602 0.669 rs12441484 chr15:77109875 G/A cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC trans rs61931739 0.963 rs12298565 chr12:34036188 C/T cg26384229 chr12:38710491 ALG10B -0.46 -6.16 -0.35 2.75e-9 Morning vs. evening chronotype; CESC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg05313129 chr8:58192883 C8orf71 -0.53 -6.09 -0.35 3.95e-9 Developmental language disorder (linguistic errors); CESC cis rs12824058 0.831 rs4759452 chr12:130812799 G/A cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs6580649 0.941 rs17122613 chr12:48460016 T/C cg05342945 chr12:48394962 COL2A1 0.51 5.91 0.34 1.07e-8 Lung cancer; CESC cis rs9840812 0.623 rs1394092 chr3:136196071 C/T cg15507776 chr3:136538369 TMEM22 0.42 5.1 0.3 6.63e-7 Fibrinogen levels; CESC cis rs6977955 1.000 rs740122 chr7:28166442 G/A cg23620719 chr7:28220237 JAZF1 0.44 5.11 0.3 6.3e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs6502050 0.835 rs8078795 chr17:80126320 C/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.97e-7 Life satisfaction; CESC cis rs7188697 0.885 rs1646010 chr16:58549204 G/C cg02549819 chr16:58548995 SETD6 -0.41 -5.09 -0.3 6.9e-7 QT interval; CESC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg04317338 chr11:64019027 PLCB3 0.88 9.06 0.49 2.95e-17 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21490846 chr12:1905324 CACNA2D4 0.54 6.07 0.35 4.42e-9 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg07507251 chr3:52567010 NT5DC2 0.4 7.06 0.4 1.5e-11 Bipolar disorder; CESC cis rs2109514 0.765 rs9649392 chr7:116107386 G/A cg12739419 chr7:116140593 CAV2 -0.34 -6.04 -0.35 5.09e-9 Prevalent atrial fibrillation; CESC cis rs708547 0.647 rs1277308 chr4:57897864 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.45 -5.89 -0.34 1.19e-8 Response to bleomycin (chromatid breaks); CESC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.78 -0.33 2.12e-8 Parkinson's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09133422 chr1:155292660 RUSC1;C1orf104 -0.47 -6.52 -0.37 3.47e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2832191 1.000 rs2832191 chr21:30489300 A/C cg08807101 chr21:30365312 RNF160 -0.66 -9.18 -0.49 1.29e-17 Dental caries; CESC trans rs1814175 0.817 rs7927373 chr11:49957640 A/C cg15704280 chr7:45808275 SEPT13 -1.03 -20.41 -0.78 2.75e-56 Height; CESC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.76 0.38 8.76e-11 Bipolar disorder; CESC cis rs17253792 0.915 rs79100824 chr14:56179606 C/T cg01858014 chr14:56050164 KTN1 -0.94 -7.27 -0.41 4.03e-12 Putamen volume; CESC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg10691866 chr7:65817282 TPST1 0.33 5.47 0.32 1.02e-7 Aortic root size; CESC cis rs7507204 0.906 rs11671513 chr19:3429937 C/T cg08380311 chr19:3435252 NFIC 0.57 6.94 0.39 2.94e-11 Height; CESC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg21248554 chr2:27665150 KRTCAP3 -0.37 -7.61 -0.42 4.7e-13 Total body bone mineral density; CESC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg23281280 chr6:28129359 ZNF389 0.5 7.01 0.4 2e-11 Depression; CESC cis rs4925386 0.959 rs4925385 chr20:60920624 A/G cg15193198 chr20:60906057 LAMA5 0.28 5.15 0.3 4.99e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs637571 0.544 rs617791 chr11:65702523 C/G cg26695010 chr11:65641043 EFEMP2 -0.46 -5.76 -0.33 2.29e-8 Eosinophil percentage of white cells; CESC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg11764359 chr7:65958608 NA 0.81 11.81 0.59 3.86e-26 Aortic root size; CESC cis rs9303401 1.000 rs6503877 chr17:56841948 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.74 9.58 0.51 7.58e-19 Cognitive test performance; CESC cis rs4474465 0.679 rs4945288 chr11:78244823 C/A cg27205649 chr11:78285834 NARS2 0.43 5.28 0.31 2.69e-7 Alzheimer's disease (survival time); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15998195 chr3:196439051 PIGX;C3orf34 0.54 6.04 0.35 5.07e-9 Gut microbiome composition (summer); CESC cis rs7264396 0.563 rs6058322 chr20:34367277 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.86 10.2 0.53 7.89e-21 Total cholesterol levels; CESC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg07395648 chr5:131743802 NA -0.43 -5.7 -0.33 3.25e-8 Breast cancer; CESC cis rs7084402 0.967 rs1649028 chr10:60280428 A/G cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC cis rs9359856 0.510 rs17293240 chr6:90396370 C/T cg13799429 chr6:90582589 CASP8AP2 0.74 8.6 0.47 6.93e-16 Bipolar disorder; CESC cis rs6570726 0.526 rs72994723 chr6:145722948 G/A cg23711669 chr6:146136114 FBXO30 -0.53 -7.12 -0.4 1.01e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg18230493 chr5:56204884 C5orf35 0.62 8.1 0.45 1.99e-14 Initial pursuit acceleration; CESC trans rs561341 0.660 rs7406043 chr17:30220152 C/G cg20587970 chr11:113659929 NA -1.03 -12.68 -0.61 4.19e-29 Hip circumference adjusted for BMI; CESC cis rs67311347 1.000 rs9848083 chr3:40466979 A/G cg01475735 chr3:40494733 NA 0.38 5.03 0.3 9.02e-7 Renal cell carcinoma; CESC cis rs5753618 0.561 rs5749265 chr22:31796897 A/C cg00478049 chr22:31556069 RNF185 -0.43 -5.11 -0.3 6.22e-7 Colorectal cancer; CESC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg07701084 chr6:150067640 NUP43 0.47 6.58 0.37 2.47e-10 Lung cancer; CESC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs55986470 0.646 rs79795396 chr2:239419181 T/C cg18131467 chr2:239335373 ASB1 -0.77 -5.49 -0.32 9.37e-8 Chronotype; CESC cis rs11792861 0.591 rs10979632 chr9:111732140 G/C cg05043794 chr9:111880884 C9orf5 -0.31 -5.65 -0.33 4.04e-8 Menarche (age at onset); CESC cis rs3126085 0.935 rs6675889 chr1:152213066 G/A cg03465714 chr1:152285911 FLG -0.43 -5.17 -0.3 4.53e-7 Atopic dermatitis; CESC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg18876405 chr7:65276391 NA -0.52 -7.1 -0.4 1.16e-11 Aortic root size; CESC cis rs11190604 1.000 rs7071271 chr10:102264824 G/A cg07080220 chr10:102295463 HIF1AN 0.64 5.88 0.34 1.23e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg17949981 chr6:28129498 ZNF389 0.42 5.2 0.3 3.96e-7 Parkinson's disease; CESC cis rs1008375 0.932 rs6844593 chr4:17659039 T/C cg16339924 chr4:17578868 LAP3 0.68 8.66 0.47 4.83e-16 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs644799 0.710 rs10765771 chr11:95521044 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.75 11.15 0.57 6.1e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs8067545 0.611 rs2526486 chr17:20101626 T/G cg13482628 chr17:19912719 NA -0.42 -5.68 -0.33 3.6e-8 Schizophrenia; CESC cis rs17376456 0.877 rs10055741 chr5:93297187 C/T cg25358565 chr5:93447407 FAM172A 1.07 10.61 0.55 3.92e-22 Diabetic retinopathy; CESC cis rs2191566 0.576 rs405763 chr19:44493547 A/G cg20607764 chr19:44506953 ZNF230 0.44 5.58 0.32 5.9e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs6570726 0.935 rs391524 chr6:145823844 A/G cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs1062177 1.000 rs12653926 chr5:151250248 C/A cg00977110 chr5:151150581 G3BP1 0.63 6.6 0.38 2.26e-10 Preschool internalizing problems; CESC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg19163074 chr7:65112434 INTS4L2 -0.46 -5.05 -0.3 8.07e-7 Aortic root size; CESC cis rs12497850 0.931 rs6442130 chr3:48778027 A/G cg07636037 chr3:49044803 WDR6 0.88 13.3 0.63 2.85e-31 Parkinson's disease; CESC cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg08917208 chr2:24149416 ATAD2B -0.58 -5.5 -0.32 8.73e-8 Lymphocyte counts; CESC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.55 0.42 7.15e-13 Bipolar disorder; CESC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.41 5.23 0.31 3.47e-7 Bipolar disorder; CESC cis rs2011503 1.000 rs16996127 chr19:19627310 T/G cg11584989 chr19:19387371 SF4 0.55 6.57 0.37 2.7e-10 Bipolar disorder; CESC cis rs2777491 0.957 rs7181911 chr15:41674060 T/C cg18705301 chr15:41695430 NDUFAF1 -0.66 -9.88 -0.52 8.63e-20 Ulcerative colitis; CESC trans rs1814175 0.616 rs1722020 chr11:49904189 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs73019876 0.772 rs2359814 chr19:22171947 A/G cg11619707 chr19:22235551 ZNF257 -0.28 -5.13 -0.3 5.6e-7 Testicular germ cell tumor; CESC cis rs7937682 0.556 rs7108048 chr11:111352299 T/C cg09085632 chr11:111637200 PPP2R1B 0.47 5.32 0.31 2.24e-7 Primary sclerosing cholangitis; CESC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.96 -0.34 8.03e-9 Total body bone mineral density; CESC cis rs7192750 0.527 rs30433 chr16:72145404 T/C cg14768367 chr16:72042858 DHODH 0.73 5.69 0.33 3.35e-8 LDL cholesterol levels;Total cholesterol levels; CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg18337363 chr3:52569053 NT5DC2 0.3 5.85 0.34 1.45e-8 Bipolar disorder; CESC cis rs854765 0.583 rs4534911 chr17:17852330 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.51 6.37 0.36 8.55e-10 Total body bone mineral density; CESC cis rs10089 1.000 rs3805607 chr5:127477418 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.3 0.53 3.71e-21 Ileal carcinoids; CESC cis rs9818941 0.824 rs7628186 chr3:157800499 T/C cg08654915 chr3:157813417 NA 0.44 7.37 0.41 2.18e-12 Height; CESC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg26338869 chr17:61819248 STRADA 0.67 8.82 0.48 1.57e-16 Prudent dietary pattern; CESC cis rs858239 0.539 rs28716381 chr7:23189015 G/A cg23682824 chr7:23144976 KLHL7 0.51 6.83 0.39 5.81e-11 Cerebrospinal fluid biomarker levels; CESC cis rs10979 1.000 rs9386033 chr6:143888520 T/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg00149659 chr3:10157352 C3orf10 0.7 8.31 0.45 5.08e-15 Alzheimer's disease; CESC cis rs9487051 0.676 rs6568560 chr6:109592851 G/A cg12927641 chr6:109611667 NA -0.37 -5.56 -0.32 6.55e-8 Reticulocyte fraction of red cells; CESC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 6.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs787274 0.543 rs4978509 chr9:115635641 C/G cg13803584 chr9:115635662 SNX30 -0.69 -6.74 -0.38 1.01e-10 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1153858 1.000 rs61365925 chr15:45650311 T/C cg14582100 chr15:45693742 SPATA5L1 0.43 6.15 0.35 2.82e-9 Homoarginine levels; CESC cis rs9419702 0.568 rs7075233 chr10:133545170 A/G cg04492858 chr10:133558786 NA -0.45 -6.51 -0.37 3.77e-10 Survival in rectal cancer; CESC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg26839252 chr6:160211577 TCP1;MRPL18 0.45 5.15 0.3 5.03e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg08888203 chr3:10149979 C3orf24 0.54 6.69 0.38 1.3e-10 Alzheimer's disease; CESC cis rs6686643 0.762 rs6672982 chr1:165612815 T/A cg19407955 chr1:165599744 MGST3 -0.54 -5.68 -0.33 3.55e-8 Total ventricular volume; CESC cis rs4566357 1.000 rs3820926 chr2:227926621 G/T cg11843606 chr2:227700838 RHBDD1 -0.43 -5.45 -0.32 1.16e-7 Coronary artery disease; CESC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC cis rs1348850 0.526 rs10803912 chr2:178407176 A/C cg22681709 chr2:178499509 PDE11A 0.49 5.29 0.31 2.53e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg16606324 chr3:10149918 C3orf24 0.43 5.36 0.31 1.81e-7 Alzheimer's disease; CESC cis rs72781680 1.000 rs72781634 chr2:24199102 C/T cg20701182 chr2:24300061 SF3B14 0.63 5.64 0.33 4.45e-8 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16144348 chr4:83812518 SEC31A 0.62 7.32 0.41 2.89e-12 Gut microbiome composition (summer); CESC cis rs7607369 0.782 rs514799 chr2:219411203 A/G cg02176678 chr2:219576539 TTLL4 0.5 9.0 0.48 4.36e-17 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs11785400 1.000 rs3735999 chr8:143746069 T/C cg10596483 chr8:143751796 JRK 0.43 5.67 0.33 3.79e-8 Schizophrenia; CESC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg11494091 chr17:61959527 GH2 -0.72 -12.28 -0.6 9.61e-28 Prudent dietary pattern; CESC cis rs11997175 0.624 rs7465686 chr8:33718321 G/A ch.8.33884649F chr8:33765107 NA 0.5 6.27 0.36 1.46e-9 Body mass index; CESC cis rs763121 0.819 rs8137829 chr22:39061030 G/A cg06022373 chr22:39101656 GTPBP1 0.88 13.88 0.65 2.66e-33 Menopause (age at onset); CESC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg18099408 chr3:52552593 STAB1 -0.32 -5.3 -0.31 2.45e-7 Bipolar disorder; CESC cis rs3806843 0.838 rs2337514 chr5:140132732 T/C cg26395211 chr5:140044315 WDR55 0.39 5.15 0.3 5.18e-7 Depressive symptoms (multi-trait analysis); CESC cis rs78456975 1.000 rs6712176 chr2:1556393 C/T cg01028140 chr2:1542097 TPO -0.51 -5.44 -0.32 1.24e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4974559 0.895 rs57037487 chr4:1386652 A/G cg02980000 chr4:1222292 CTBP1 0.74 8.88 0.48 1.07e-16 Systolic blood pressure; CESC trans rs875971 0.767 rs1695815 chr7:65831344 A/G cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.66e-9 Aortic root size; CESC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg04518342 chr5:131593106 PDLIM4 0.41 6.08 0.35 4.16e-9 Breast cancer; CESC cis rs6120849 0.754 rs6088691 chr20:33633758 C/T cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs924607 1.000 rs1697978 chr5:642829 A/G cg09021430 chr5:549028 NA -0.38 -6.85 -0.39 5.11e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs919433 0.889 rs788001 chr2:198213720 C/T cg10820045 chr2:198174542 NA 0.39 5.78 0.33 2.05e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9300255 0.602 rs1716168 chr12:123651966 C/G cg00376283 chr12:123451042 ABCB9 -0.69 -8.65 -0.47 4.95e-16 Neutrophil percentage of white cells; CESC cis rs11122272 0.677 rs2808615 chr1:231550171 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.58 7.93 0.44 5.95e-14 Hemoglobin concentration; CESC cis rs965513 0.530 rs1912995 chr9:100530899 A/G cg13688889 chr9:100608707 NA -0.42 -5.56 -0.32 6.74e-8 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs35955747 0.677 rs4820974 chr22:31869467 A/C cg25791279 chr22:32026902 PISD -0.44 -5.27 -0.31 2.81e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs735539 1.000 rs9579929 chr13:21282724 C/T cg04906043 chr13:21280425 IL17D 0.39 6.03 0.35 5.58e-9 Dental caries; CESC cis rs1008375 0.932 rs13109475 chr4:17677565 C/G cg02297831 chr4:17616191 MED28 -0.46 -5.49 -0.32 9.2e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs6963495 0.546 rs2697020 chr7:105150046 C/T cg13798780 chr7:105162888 PUS7 0.5 6.09 0.35 4.04e-9 Bipolar disorder (body mass index interaction); CESC cis rs2836974 0.931 rs2989330 chr21:40716209 A/G cg17971929 chr21:40555470 PSMG1 0.88 10.63 0.55 3.21e-22 Cognitive function; CESC cis rs1799949 0.965 rs4793237 chr17:41436595 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.52 7.37 0.41 2.17e-12 Menopause (age at onset); CESC cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg21918786 chr6:109611834 NA -0.39 -6.04 -0.35 5.09e-9 Reticulocyte fraction of red cells; CESC cis rs6032067 0.777 rs13042694 chr20:43799368 G/A cg10761708 chr20:43804764 PI3 0.56 6.66 0.38 1.58e-10 Blood protein levels; CESC cis rs16866061 1.000 rs72974269 chr2:225454907 C/T cg12698349 chr2:225449008 CUL3 0.74 10.43 0.54 1.41e-21 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg24549020 chr5:56110836 MAP3K1 0.66 7.53 0.42 7.74e-13 Initial pursuit acceleration; CESC cis rs9814567 0.806 rs9839705 chr3:134323819 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.38 -5.06 -0.3 7.86e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg20090143 chr19:45452003 APOC2 0.36 6.35 0.36 9.53e-10 Blood protein levels; CESC cis rs10463316 0.894 rs7729216 chr5:150762277 A/G cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC cis rs7264396 1.000 rs224424 chr20:34147998 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -7.09 -0.4 1.25e-11 Total cholesterol levels; CESC cis rs55871839 0.708 rs10093993 chr8:59811454 T/C cg07426533 chr8:59803705 TOX -0.47 -7.01 -0.4 1.95e-11 Pneumonia; CESC cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.13 0.3 5.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs17253792 0.822 rs77676035 chr14:56096229 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs644799 0.932 rs10831447 chr11:95663017 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.63 -7.09 -0.4 1.22e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs60843830 1.000 rs36216559 chr2:262335 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.8 10.47 0.54 1.11e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4889855 0.530 rs12451459 chr17:78589668 G/A cg16591659 chr17:78472290 NA 0.34 5.48 0.32 9.83e-8 Fractional excretion of uric acid; CESC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.24 -0.31 3.23e-7 Lung cancer; CESC cis rs1152591 0.524 rs1255992 chr14:64662895 A/G cg23250157 chr14:64679961 SYNE2 0.41 5.87 0.34 1.31e-8 Atrial fibrillation; CESC cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg17211192 chr8:82754475 SNX16 -0.58 -7.39 -0.41 1.95e-12 Diastolic blood pressure; CESC cis rs11581903 0.568 rs6686035 chr1:53080008 A/C cg19751897 chr1:52520827 TXNDC12;BTF3L4 0.64 5.09 0.3 6.92e-7 Joint mobility (Beighton score); CESC cis rs7824557 0.628 rs58283816 chr8:11192551 G/C cg21775007 chr8:11205619 TDH 0.55 8.74 0.47 2.75e-16 Retinal vascular caliber; CESC cis rs9911578 0.967 rs7502208 chr17:57165097 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.17 0.3 4.51e-7 Intelligence (multi-trait analysis); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg03350042 chr15:40733177 BAHD1 -0.43 -6.47 -0.37 4.82e-10 Breast cancer; CESC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg09658497 chr7:2847517 GNA12 -0.45 -6.53 -0.37 3.25e-10 Height; CESC cis rs2011503 0.782 rs8113006 chr19:19669441 C/G cg11584989 chr19:19387371 SF4 -0.46 -5.21 -0.3 3.87e-7 Bipolar disorder; CESC cis rs11711311 0.910 rs62265549 chr3:113396234 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.67 8.6 0.47 7.08e-16 IgG glycosylation; CESC cis rs6141600 0.760 rs2746103 chr20:34703934 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -5.37 -0.31 1.72e-7 Height;Hip circumference; CESC cis rs617219 0.550 rs115009495 chr5:78433831 C/T cg22188827 chr5:78429774 NA -0.43 -5.09 -0.3 6.87e-7 Betaine levels in individuals undergoing cardiac evaluation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02544571 chr7:139187165 NA -0.59 -6.43 -0.37 5.78e-10 Gut microbiome composition (summer); CESC cis rs796364 0.760 rs74993507 chr2:201068684 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -5.97 -0.34 7.5e-9 Schizophrenia; CESC cis rs2997447 0.655 rs2275950 chr1:26385003 T/C cg19633962 chr1:26362018 EXTL1 -0.56 -5.72 -0.33 2.87e-8 QRS complex (12-leadsum); CESC cis rs2228479 0.850 rs76075456 chr16:89834270 T/C cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs3820068 0.581 rs72645890 chr1:15930602 A/G cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs1124376 1.000 rs61138004 chr3:20145855 C/G cg05072819 chr3:20081367 KAT2B 0.51 5.51 0.32 8.5e-8 Bipolar disorder and schizophrenia; CESC trans rs853679 0.599 rs13193295 chr6:28003228 C/G cg01620082 chr3:125678407 NA -0.81 -6.37 -0.36 8.23e-10 Depression; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21947590 chr19:620162 POLRMT 0.45 6.25 0.36 1.67e-9 Fibrinogen levels; CESC cis rs5758511 0.689 rs17478227 chr22:42654327 C/G cg00645731 chr22:42541494 CYP2D7P1 -0.54 -7.04 -0.4 1.64e-11 Birth weight; CESC cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.27 -0.36 1.45e-9 Mood instability; CESC trans rs1814175 0.585 rs4881661 chr11:50000117 A/G cg15704280 chr7:45808275 SEPT13 -1.0 -18.49 -0.75 1.41e-49 Height; CESC cis rs7786877 0.583 rs41303510 chr7:100226129 C/T cg20848291 chr7:100343083 ZAN -0.67 -7.01 -0.4 1.96e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs131777 0.526 rs86337 chr22:51020668 C/A cg00083937 chr22:51039805 MAPK8IP2 0.36 5.18 0.3 4.48e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs4660261 0.526 rs810680 chr1:44347856 C/T cg12908607 chr1:44402522 ARTN -0.48 -6.94 -0.39 3.05e-11 Intelligence (multi-trait analysis); CESC trans rs2727020 0.702 rs609054 chr11:49219725 C/G cg03929089 chr4:120376271 NA 0.78 11.83 0.59 3.28e-26 Coronary artery disease; CESC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg21970626 chr13:21893289 NA -0.42 -6.31 -0.36 1.14e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs12410462 0.579 rs116423559 chr1:227575014 A/G cg23173402 chr1:227635558 NA 0.68 5.62 0.33 4.88e-8 Major depressive disorder; CESC cis rs7772486 0.686 rs2328708 chr6:146095739 G/A cg23711669 chr6:146136114 FBXO30 -0.86 -12.57 -0.61 1.01e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs17253792 0.822 rs17253723 chr14:56154015 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs7312774 0.618 rs12316286 chr12:107343020 C/A cg16260113 chr12:107380972 MTERFD3 0.81 7.42 0.41 1.55e-12 Severe influenza A (H1N1) infection; CESC cis rs6598955 0.670 rs3795685 chr1:26601385 A/G cg00852783 chr1:26633632 UBXN11 -0.4 -5.86 -0.34 1.37e-8 Obesity-related traits; CESC cis rs2880765 0.743 rs6497191 chr15:86011501 T/C cg10818794 chr15:86012489 AKAP13 -0.35 -5.4 -0.31 1.49e-7 Coronary artery disease; CESC trans rs61931739 0.500 rs7484658 chr12:34515879 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.55 0.42 7.05e-13 Morning vs. evening chronotype; CESC cis rs2073300 0.609 rs6132606 chr20:23367453 G/A cg12062639 chr20:23401060 NAPB 1.07 8.85 0.48 1.29e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7264396 0.790 rs3787166 chr20:34229072 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -9.09 -0.49 2.4e-17 Total cholesterol levels; CESC cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg03467027 chr4:99064603 C4orf37 0.48 6.0 0.35 6.63e-9 Colonoscopy-negative controls vs population controls; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.35 5.17 0.3 4.67e-7 Hemoglobin concentration; CESC trans rs1545843 0.564 rs2061477 chr12:84909015 G/A cg03015433 chr16:56623111 MT3 0.34 6.14 0.35 3.07e-9 Major depressive disorder; CESC cis rs8180040 0.966 rs13072802 chr3:47346415 G/C cg27129171 chr3:47204927 SETD2 0.66 10.03 0.52 2.81e-20 Colorectal cancer; CESC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg25036284 chr2:26402008 FAM59B -0.82 -9.33 -0.5 4.47e-18 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19701416 chr10:28592092 NA 0.45 6.04 0.35 5.14e-9 Systemic lupus erythematosus; CESC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.96 14.51 0.67 1.65e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.6 0.33 5.36e-8 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02916964 chr12:56326165 DGKA -0.47 -6.09 -0.35 3.96e-9 Fibrinogen levels; CESC cis rs599083 0.530 rs546803 chr11:68186392 C/T cg16797656 chr11:68205561 LRP5 -0.41 -5.33 -0.31 2.11e-7 Bone mineral density (spine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05966498 chr5:10761293 DAP 0.58 6.36 0.36 8.77e-10 Gut microbiome composition (summer); CESC cis rs2425143 1.000 rs74785978 chr20:34373234 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.7 6.06 0.35 4.71e-9 Blood protein levels; CESC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg17971929 chr21:40555470 PSMG1 -0.85 -12.3 -0.6 8.25e-28 Cognitive function; CESC cis rs9790314 0.521 rs2122527 chr3:161091636 G/A cg04691961 chr3:161091175 C3orf57 -0.37 -5.11 -0.3 6.1e-7 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.544 rs35160902 chr4:98974690 A/T cg05340658 chr4:99064831 C4orf37 0.78 11.86 0.59 2.6e-26 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg11494091 chr17:61959527 GH2 0.73 12.66 0.61 4.86e-29 Prudent dietary pattern; CESC cis rs2742234 0.590 rs1254962 chr10:43696992 G/A cg15436174 chr10:43711423 RASGEF1A 0.5 5.85 0.34 1.45e-8 Hirschsprung disease; CESC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg17971929 chr21:40555470 PSMG1 1.04 15.63 0.69 1.86e-39 Cognitive function; CESC cis rs597539 0.690 rs11228383 chr11:68623228 T/G cg01988459 chr11:68622903 NA -0.41 -5.3 -0.31 2.4e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs792448 0.743 rs7519959 chr1:212498652 T/C cg01059126 chr1:212459029 PPP2R5A -0.43 -5.31 -0.31 2.29e-7 White blood cell count (basophil); CESC cis rs473651 0.935 rs474478 chr2:239335473 C/T cg18131467 chr2:239335373 ASB1 1.04 20.94 0.79 4e-58 Multiple system atrophy; CESC cis rs6502050 0.731 rs4789730 chr17:80145983 T/A cg23985595 chr17:80112537 CCDC57 -0.4 -6.33 -0.36 1.06e-9 Life satisfaction; CESC cis rs1003719 0.788 rs2835586 chr21:38461326 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.21e-16 Eye color traits; CESC cis rs11958404 1.000 rs72816528 chr5:157410949 G/A cg05962755 chr5:157440814 NA 0.53 6.02 0.35 5.72e-9 IgG glycosylation; CESC cis rs2295359 1.000 rs963427 chr1:67609347 A/G cg03340356 chr1:67600835 NA 0.36 5.83 0.34 1.62e-8 Psoriasis; CESC cis rs1707322 1.000 rs12124291 chr1:46432132 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.83 7.54 0.42 7.47e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs9929218 1.000 rs2113199 chr16:68814502 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.64 -8.36 -0.46 3.57e-15 Colorectal cancer; CESC cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg06544989 chr22:39130855 UNC84B -0.51 -8.83 -0.48 1.41e-16 Menopause (age at onset); CESC cis rs9640161 0.702 rs1962004 chr7:150020381 G/A cg17279839 chr7:150038598 RARRES2 0.47 5.43 0.32 1.25e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs2737618 0.651 rs2249156 chr1:200083541 A/G cg21825944 chr1:200113062 NR5A2 0.47 7.17 0.4 7.36e-12 Uric acid levels; CESC trans rs1814175 0.676 rs1851859 chr11:49860405 A/T cg11707556 chr5:10655725 ANKRD33B -0.42 -6.12 -0.35 3.39e-9 Height; CESC cis rs734999 0.505 rs4445406 chr1:2539400 T/C cg18854424 chr1:2615690 NA 0.29 5.71 0.33 2.95e-8 Ulcerative colitis; CESC trans rs35110281 0.805 rs3788062 chr21:44991159 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 6.89 0.39 4.12e-11 Mean corpuscular volume; CESC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg03060546 chr3:49711283 APEH 0.52 6.32 0.36 1.07e-9 Parkinson's disease; CESC cis rs2242194 0.816 rs11264296 chr1:154994750 T/C cg24250549 chr1:154909240 PMVK 0.39 5.1 0.3 6.46e-7 Schizophrenia; CESC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2273669 0.667 rs12215736 chr6:109330367 A/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg26343298 chr8:95960752 TP53INP1 0.32 5.25 0.31 3.1e-7 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09657265 chr6:123110763 SMPDL3A 0.54 6.06 0.35 4.54e-9 Gut microbiome composition (summer); CESC cis rs1499972 0.938 rs861001 chr3:117720355 C/T cg07612923 chr3:117604196 NA 0.75 5.5 0.32 8.82e-8 Schizophrenia; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg04761648 chr13:26829199 CDK8 0.46 6.3 0.36 1.26e-9 Positive affect; CESC cis rs1538970 0.924 rs4660855 chr1:45899795 A/G cg03146154 chr1:46216737 IPP 0.44 5.09 0.3 6.74e-7 Platelet count; CESC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs2228479 0.850 rs17227263 chr16:89810598 G/A cg06558623 chr16:89946397 TCF25 1.17 9.44 0.5 1.96e-18 Skin colour saturation; CESC cis rs2180341 1.000 rs4895822 chr6:127642703 T/C cg27446573 chr6:127587934 RNF146 1.09 16.35 0.71 5.12e-42 Breast cancer; CESC cis rs7429990 0.965 rs4392441 chr3:48077701 C/T cg11946769 chr3:48343235 NME6 -0.43 -5.22 -0.31 3.62e-7 Educational attainment (years of education); CESC cis rs2072732 0.821 rs7412983 chr1:2943183 A/C cg15211996 chr1:2936768 ACTRT2 0.35 5.74 0.33 2.65e-8 Plateletcrit; CESC cis rs6460942 0.915 rs17444141 chr7:12460971 T/G cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs7264396 0.635 rs6058344 chr20:34475038 A/G cg17201900 chr20:34330562 RBM39 0.5 5.07 0.3 7.37e-7 Total cholesterol levels; CESC cis rs2072499 0.898 rs2758609 chr1:156202868 G/A cg24450063 chr1:156163899 SLC25A44 0.8 11.95 0.59 1.24e-26 Testicular germ cell tumor; CESC cis rs2404602 0.735 rs11629888 chr15:76719880 A/T cg23625390 chr15:77176239 SCAPER -0.41 -5.32 -0.31 2.23e-7 Blood metabolite levels; CESC cis rs910316 0.967 rs10246 chr14:75544470 T/A cg11812906 chr14:75593930 NEK9 0.9 15.29 0.68 2.79e-38 Height; CESC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 12.01 0.59 7.93e-27 Platelet count; CESC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg25985355 chr7:65971099 NA 0.32 5.34 0.31 2e-7 Aortic root size; CESC cis rs9640161 0.673 rs34489187 chr7:150044379 G/A cg21361702 chr7:150065534 REPIN1 0.57 6.01 0.35 6.25e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs477692 0.967 rs488143 chr10:131407369 A/C cg05714579 chr10:131428358 MGMT 0.54 7.59 0.42 5.45e-13 Response to temozolomide; CESC cis rs9911578 1.000 rs9901114 chr17:56575208 G/A cg12560992 chr17:57184187 TRIM37 -0.91 -15.23 -0.68 4.63e-38 Intelligence (multi-trait analysis); CESC cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.89 12.15 0.6 2.69e-27 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01198208 chr4:87893007 AFF1 -0.55 -6.19 -0.36 2.24e-9 Gut microbiome composition (summer); CESC cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg18904891 chr8:8559673 CLDN23 0.69 7.99 0.44 4.17e-14 Obesity-related traits; CESC cis rs738322 1.000 rs738320 chr22:38568715 G/T cg17652424 chr22:38574118 PLA2G6 -0.34 -6.03 -0.35 5.39e-9 Cutaneous nevi; CESC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg06505273 chr16:24850292 NA 0.51 6.29 0.36 1.32e-9 Intelligence (multi-trait analysis); CESC cis rs35110281 0.682 rs162379 chr21:44925334 A/G cg01579765 chr21:45077557 HSF2BP 0.44 7.75 0.43 2.03e-13 Mean corpuscular volume; CESC cis rs2191566 0.555 rs397964 chr19:44493969 A/T cg20607764 chr19:44506953 ZNF230 0.47 5.95 0.34 8.31e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs11966931 0.711 rs11964340 chr6:108111651 G/T cg10566610 chr6:108093680 SCML4 0.28 5.06 0.3 7.83e-7 Neutrophil percentage of white cells; CESC cis rs9486719 0.522 rs4839683 chr6:96851933 A/G cg06623918 chr6:96969491 KIAA0776 0.75 8.48 0.46 1.63e-15 Migraine;Coronary artery disease; CESC cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg19482086 chr6:160211437 TCP1;MRPL18 0.67 8.1 0.45 2.05e-14 Age-related macular degeneration (geographic atrophy); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17351116 chr20:25371719 ABHD12 0.48 6.04 0.35 5.22e-9 Gut microbiota (bacterial taxa); CESC trans rs11098499 0.954 rs10005644 chr4:120298477 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs910316 1.000 rs2268617 chr14:75608728 G/A cg11812906 chr14:75593930 NEK9 0.9 15.64 0.69 1.67e-39 Height; CESC cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg15147215 chr3:52552868 STAB1 -0.34 -5.69 -0.33 3.29e-8 Electroencephalogram traits; CESC cis rs28595532 0.748 rs72670248 chr4:119335536 A/C cg21605333 chr4:119757512 SEC24D 1.01 5.58 0.32 5.98e-8 Cannabis dependence symptom count; CESC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.84 0.43 1.07e-13 Menopause (age at onset); CESC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.84 9.03 0.49 3.56e-17 Platelet count; CESC cis rs6594713 0.717 rs13436825 chr5:112817687 T/A cg12552261 chr5:112820674 MCC 0.56 5.5 0.32 8.78e-8 Brain cytoarchitecture; CESC cis rs698833 0.548 rs6544760 chr2:44553014 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.55 5.84 0.34 1.52e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg14558114 chr2:88469736 THNSL2 0.59 5.43 0.32 1.25e-7 Plasma clusterin levels; CESC cis rs10979 0.557 rs9390117 chr6:143907590 C/T cg25407410 chr6:143891975 LOC285740 -0.49 -6.31 -0.36 1.16e-9 Hypospadias; CESC cis rs1707322 1.000 rs6671754 chr1:46433990 A/G cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2270927 1.000 rs2270927 chr5:75591710 C/G cg13563193 chr19:33072644 PDCD5 0.73 6.43 0.37 6.06e-10 Mean corpuscular volume; CESC cis rs896543 0.702 rs6715324 chr2:237495510 C/T cg25295825 chr2:237489920 CXCR7 0.73 9.34 0.5 4.06e-18 Alcohol dependence (age at onset); CESC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg08888203 chr3:10149979 C3orf24 0.49 6.17 0.35 2.49e-9 Alzheimer's disease; CESC cis rs9457247 1.000 rs389946 chr6:167407268 T/C cg07741184 chr6:167504864 NA 0.29 5.31 0.31 2.32e-7 Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27067419 chr5:54830434 PPAP2A;RNF138P1 -0.45 -6.68 -0.38 1.43e-10 Fibrinogen levels; CESC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.93e-7 Lung cancer; CESC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.5 -0.37 4e-10 Electroencephalogram traits; CESC cis rs15676 0.947 rs6478854 chr9:131588888 G/C cg00228799 chr9:131580591 ENDOG -0.44 -5.5 -0.32 9.01e-8 Blood metabolite levels; CESC cis rs4481887 0.741 rs1361413 chr1:248529521 C/G cg26353448 chr1:248524236 OR2T4 0.35 5.03 0.3 9.14e-7 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02013961 chr6:142468197 VTA1 0.57 6.26 0.36 1.56e-9 Gut microbiome composition (summer); CESC cis rs910316 1.000 rs7147118 chr14:75610170 G/C cg08847533 chr14:75593920 NEK9 1.03 20.54 0.78 9.98e-57 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16929187 chr11:71791555 LRTOMT;NUMA1 0.57 6.1 0.35 3.73e-9 Gut microbiome composition (summer); CESC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg14393609 chr7:65229607 NA -0.52 -7.15 -0.4 8.31e-12 Aortic root size; CESC cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg03709012 chr19:19516395 GATAD2A 1.01 15.7 0.69 1.01e-39 Tonsillectomy; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07136949 chr6:7986672 MGC26597 0.47 6.33 0.36 1.04e-9 Ulcerative colitis; CESC cis rs6062302 0.522 rs6090476 chr20:62248001 G/A cg06363034 chr20:62225388 GMEB2 -0.5 -6.41 -0.37 6.66e-10 Glioblastoma; CESC cis rs854765 0.551 rs12600546 chr17:17867614 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.06 0.4 1.45e-11 Total body bone mineral density; CESC cis rs9329289 0.888 rs11251273 chr10:2540300 G/C cg18171855 chr10:2543474 NA 0.39 6.02 0.35 5.73e-9 Age-related hearing impairment; CESC cis rs4243830 0.850 rs908273 chr1:6588604 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -8.53 -0.46 1.1e-15 Body mass index; CESC cis rs6076065 0.748 rs2281431 chr20:23399304 C/G cg11657817 chr20:23433608 CST11 0.41 6.17 0.35 2.49e-9 Facial morphology (factor 15, philtrum width); CESC cis rs2841277 0.676 rs10438246 chr14:105410183 T/C cg17340268 chr14:105411764 AHNAK2 -0.51 -6.88 -0.39 4.35e-11 Rheumatoid arthritis; CESC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg11366901 chr6:160182831 ACAT2 -0.62 -7.88 -0.44 8.54e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.44 -5.46 -0.32 1.1e-7 Tonsillectomy; CESC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg18301423 chr5:131593218 PDLIM4 0.38 5.37 0.31 1.73e-7 Breast cancer; CESC cis rs7000551 0.751 rs2469770 chr8:22379856 G/A cg12081754 chr8:22256438 SLC39A14 0.46 6.08 0.35 4.16e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs3820928 0.874 rs1054413 chr2:227867719 A/G cg05526886 chr2:227700861 RHBDD1 0.42 5.22 0.31 3.66e-7 Pulmonary function; CESC cis rs28374715 0.532 rs28535540 chr15:41659277 G/A cg20272979 chr15:41787780 ITPKA 0.41 5.1 0.3 6.62e-7 Ulcerative colitis; CESC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.24 -0.57 3.08e-24 Glomerular filtration rate (creatinine); CESC cis rs6066835 0.572 rs4616535 chr20:47248808 C/T cg18078177 chr20:47281410 PREX1 0.66 5.11 0.3 6.29e-7 Multiple myeloma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04165840 chr10:105156204 USMG5;PDCD11 0.56 6.57 0.37 2.63e-10 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg24531977 chr5:56204891 C5orf35 -0.87 -11.43 -0.57 7.27e-25 Initial pursuit acceleration; CESC trans rs17307778 1.000 rs1477571 chr11:25358529 C/T cg22888484 chr20:37075185 SNHG11 -0.63 -6.17 -0.35 2.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg07395648 chr5:131743802 NA -0.43 -5.68 -0.33 3.62e-8 Breast cancer; CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg22907277 chr7:1156413 C7orf50 0.44 6.41 0.37 6.75e-10 Longevity;Endometriosis; CESC cis rs1707322 1.000 rs10890370 chr1:46389217 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.69 0.33 3.41e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9297145 0.958 rs11975761 chr7:98766688 G/A cg05967295 chr7:98741636 SMURF1 -0.98 -12.85 -0.62 1.04e-29 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg05283184 chr6:79620031 NA -0.44 -6.64 -0.38 1.79e-10 Intelligence (multi-trait analysis); CESC trans rs116095464 0.867 rs10074958 chr5:230828 C/T cg00938859 chr5:1591904 SDHAP3 0.62 6.74 0.38 9.96e-11 Breast cancer; CESC cis rs2732480 0.577 rs1489109 chr12:48738780 C/A cg04545296 chr12:48745243 ZNF641 0.44 7.29 0.41 3.69e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9916302 0.629 rs9972882 chr17:37807698 A/C cg00129232 chr17:37814104 STARD3 -0.69 -8.91 -0.48 8.28e-17 Glomerular filtration rate (creatinine); CESC cis rs62229266 0.804 rs56279140 chr21:37424361 C/T cg12218747 chr21:37451666 NA -0.43 -6.09 -0.35 3.99e-9 Mitral valve prolapse; CESC cis rs9430161 0.579 rs6694011 chr1:11036935 G/A cg27631724 chr1:11040367 C1orf127 0.46 7.81 0.43 1.36e-13 Ewing sarcoma; CESC cis rs35160687 0.623 rs11689971 chr2:86474471 A/G cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.18 -0.3 4.5e-7 Night sleep phenotypes; CESC cis rs17764205 0.777 rs17696630 chr19:3261995 A/G cg02612712 chr19:3985498 EEF2 -0.71 -5.74 -0.33 2.6e-8 Bipolar disorder and schizophrenia; CESC cis rs67460515 0.892 rs7610985 chr3:161062848 G/A cg03342759 chr3:160939853 NMD3 -0.54 -7.84 -0.43 1.13e-13 Parkinson's disease; CESC cis rs9486719 0.656 rs6924957 chr6:96853579 G/T cg18709589 chr6:96969512 KIAA0776 0.44 5.46 0.32 1.11e-7 Migraine;Coronary artery disease; CESC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.17 0.3 4.51e-7 Menopause (age at onset); CESC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 9.57 0.51 8.02e-19 Alzheimer's disease; CESC cis rs4891159 0.756 rs3892540 chr18:74118058 C/T cg24786174 chr18:74118243 ZNF516 -0.73 -11.26 -0.57 2.72e-24 Longevity; CESC cis rs17253792 0.822 rs77676035 chr14:56096229 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs9325144 0.624 rs12231544 chr12:38901956 C/T cg26384229 chr12:38710491 ALG10B -0.56 -7.86 -0.43 9.61e-14 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14049615 chr4:87928107 AFF1 0.58 6.85 0.39 5.27e-11 Gut microbiome composition (summer); CESC cis rs1728785 1.000 rs1728801 chr16:68571457 A/C cg02972257 chr16:68554789 NA -0.55 -6.34 -0.36 9.7e-10 Ulcerative colitis; CESC cis rs1267303 0.642 rs6696219 chr1:47000408 T/C cg25110126 chr1:46999211 NA 0.84 10.81 0.55 8.26e-23 Monobrow; CESC cis rs939574 0.722 rs55951006 chr2:220132151 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.89 6.96 0.39 2.6e-11 Platelet distribution width; CESC cis rs9814567 1.000 rs2370641 chr3:134222161 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.98 -0.34 7.14e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 10.36 0.54 2.49e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg26668713 chr11:65405903 SIPA1 0.69 7.63 0.42 4.32e-13 Blood pressure (age interaction); CESC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg03452623 chr4:187889614 NA -0.87 -14.81 -0.67 1.44e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs858239 0.508 rs7805071 chr7:23190212 C/T cg23682824 chr7:23144976 KLHL7 0.46 5.85 0.34 1.45e-8 Cerebrospinal fluid biomarker levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14426517 chr6:153323975 MTRF1L 0.56 6.46 0.37 5.11e-10 Gut microbiome composition (summer); CESC trans rs7980799 0.653 rs1384598 chr12:33622899 T/A cg26384229 chr12:38710491 ALG10B -0.55 -7.81 -0.43 1.32e-13 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs3796352 1.000 rs3097417 chr3:53088601 C/G cg12962167 chr3:53033115 SFMBT1 -0.63 -5.95 -0.34 8.59e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs6665290 0.904 rs1045287 chr1:227178962 C/T cg10327440 chr1:227177885 CDC42BPA 1.2 30.4 0.88 2.27e-88 Myeloid white cell count; CESC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg05368731 chr17:41323189 NBR1 0.78 10.79 0.55 9.37e-23 Menopause (age at onset); CESC cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27050990 chr7:2629313 IQCE -0.51 -6.05 -0.35 5e-9 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg22143856 chr6:28129313 ZNF389 0.52 6.6 0.38 2.24e-10 Depression; CESC cis rs6963495 0.818 rs73192141 chr7:105201129 T/G cg13798780 chr7:105162888 PUS7 0.77 7.57 0.42 6.35e-13 Bipolar disorder (body mass index interaction); CESC cis rs9513593 1.000 rs12861519 chr13:100029555 A/C cg21788972 chr13:99853209 UBAC2 0.6 6.98 0.39 2.4e-11 Psoriasis; CESC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg26335602 chr6:28129616 ZNF389 0.54 7.3 0.41 3.37e-12 Depression; CESC cis rs563538 1 rs563538 chr13:37433721 A/G cg00891593 chr13:37393154 RFXAP -0.68 -5.12 -0.3 5.95e-7 Spontaneous preterm birth (preterm birth); CESC trans rs66887589 0.616 rs11732621 chr4:120212883 A/C cg25214090 chr10:38739885 LOC399744 0.43 6.11 0.35 3.56e-9 Diastolic blood pressure; CESC cis rs9467711 0.606 rs2393667 chr6:26421345 T/C cg14345882 chr6:26364793 BTN3A2 0.61 5.84 0.34 1.56e-8 Autism spectrum disorder or schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22053042 chr19:50119262 PRR12 0.48 6.28 0.36 1.38e-9 Fibrinogen levels; CESC cis rs11098499 1.000 rs13435802 chr4:120177960 A/T cg24375607 chr4:120327624 NA -0.42 -5.07 -0.3 7.43e-7 Corneal astigmatism; CESC cis rs4604732 0.631 rs12039596 chr1:247624766 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -7.12 -0.4 9.93e-12 Bipolar disorder; CESC cis rs1005277 0.579 rs1780122 chr10:38529509 C/A cg00409905 chr10:38381863 ZNF37A -0.51 -6.77 -0.38 8.46e-11 Extrinsic epigenetic age acceleration; CESC cis rs9487051 0.676 rs7773775 chr6:109600339 T/C cg12927641 chr6:109611667 NA -0.36 -5.43 -0.32 1.28e-7 Reticulocyte fraction of red cells; CESC cis rs28647808 0.881 rs7029386 chr9:136263736 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC cis rs477692 0.544 rs7923750 chr10:131446895 G/C cg24747557 chr10:131355152 MGMT 0.46 6.19 0.36 2.33e-9 Response to temozolomide; CESC cis rs9814567 1.000 rs2056603 chr3:134312749 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.71 -0.33 2.97e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1707322 0.752 rs8179296 chr1:46143791 G/A cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs74181299 0.819 rs2723086 chr2:65297686 C/T cg05010058 chr2:65284262 CEP68 0.34 5.7 0.33 3.14e-8 Pulse pressure; CESC cis rs7202877 0.706 rs8055609 chr16:75402088 C/T cg04384234 chr16:75411784 CFDP1 -0.47 -5.79 -0.33 2.02e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs2228479 0.867 rs35542367 chr16:89965825 G/C cg04013166 chr16:89971882 TCF25 0.76 7.2 0.4 6.4e-12 Skin colour saturation; CESC cis rs2797160 0.651 rs6939969 chr6:126034563 C/T cg05901451 chr6:126070800 HEY2 0.5 7.45 0.42 1.3e-12 Endometrial cancer; CESC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg15782153 chr7:917662 C7orf20 0.52 5.69 0.33 3.4e-8 Cerebrospinal P-tau181p levels; CESC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg04267008 chr7:1944627 MAD1L1 -0.72 -9.22 -0.49 9.39e-18 Bipolar disorder and schizophrenia; CESC cis rs7216064 1.000 rs60432293 chr17:65860407 T/C cg12091567 chr17:66097778 LOC651250 -0.81 -9.17 -0.49 1.36e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs454510 0.857 rs838990 chr1:120193252 A/G cg16322792 chr1:120165303 ZNF697 0.39 6.16 0.35 2.64e-9 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs2075371 0.501 rs1613152 chr7:134019837 A/G cg20476274 chr7:133979776 SLC35B4 0.41 5.32 0.31 2.16e-7 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10705503 chr12:102513685 C12orf48;NUP37 0.53 6.15 0.35 2.88e-9 Gut microbiome composition (summer); CESC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg16049864 chr8:95962084 TP53INP1 0.59 9.79 0.52 1.58e-19 Type 2 diabetes; CESC cis rs9291683 0.620 rs7699512 chr4:10125808 C/T cg11266682 chr4:10021025 SLC2A9 -0.48 -8.58 -0.47 8.08e-16 Bone mineral density; CESC cis rs9815354 0.812 rs56332587 chr3:42012714 T/C cg03022575 chr3:42003672 ULK4 0.68 6.13 0.35 3.21e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs12599106 0.707 rs2163977 chr16:34916134 A/G cg15383120 chr6:291909 DUSP22 -0.61 -7.62 -0.42 4.6e-13 Menopause (age at onset); CESC cis rs9549367 0.756 rs2302756 chr13:113900197 G/A cg18105134 chr13:113819100 PROZ 0.66 8.0 0.44 3.96e-14 Platelet distribution width; CESC cis rs72945132 0.678 rs12786421 chr11:70235314 G/C cg14191688 chr11:70257035 CTTN 0.41 5.12 0.3 5.9e-7 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07589813 chr16:14726517 BFAR 0.45 6.56 0.37 2.87e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11165623 0.792 rs12132069 chr1:96918809 A/C cg10631902 chr5:14652156 NA -0.57 -8.53 -0.46 1.11e-15 Hip circumference;Waist circumference; CESC cis rs36051895 0.659 rs12349508 chr9:5184222 T/G cg02405213 chr9:5042618 JAK2 -0.6 -7.02 -0.4 1.92e-11 Pediatric autoimmune diseases; CESC cis rs1881797 0.932 rs41305741 chr1:247689543 A/G cg05639522 chr1:247681581 NA 0.45 5.99 0.35 6.71e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs9322193 0.923 rs12175504 chr6:149985215 T/G cg07701084 chr6:150067640 NUP43 0.41 5.56 0.32 6.68e-8 Lung cancer; CESC cis rs9611565 0.694 rs5758389 chr22:41941749 T/C cg06481639 chr22:41940642 POLR3H -0.47 -5.45 -0.32 1.14e-7 Vitiligo; CESC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg22823121 chr1:150693482 HORMAD1 0.4 5.7 0.33 3.2e-8 Melanoma; CESC cis rs561341 1.000 rs473356 chr17:30321762 G/C cg19193384 chr17:30244184 NA -0.7 -6.58 -0.37 2.49e-10 Hip circumference adjusted for BMI; CESC trans rs2472476 0.900 rs2274870 chr9:107515214 G/A cg14553338 chr2:66689807 MEIS1 0.41 6.16 0.35 2.76e-9 Obesity-related traits; CESC cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 7.22 0.41 5.52e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4722166 0.598 rs4722171 chr7:22785717 A/G cg13104385 chr7:22767384 IL6 0.48 6.36 0.36 8.7e-10 Lung cancer; CESC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg04553112 chr3:125709451 NA -0.54 -5.75 -0.33 2.4e-8 Blood pressure (smoking interaction); CESC cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg13944838 chr5:179740914 GFPT2 -0.7 -9.03 -0.49 3.57e-17 Height; CESC cis rs2236918 0.710 rs1635510 chr1:242027500 G/T cg17736920 chr1:242011382 EXO1 0.55 6.97 0.39 2.52e-11 Menopause (age at onset); CESC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.1 -12.68 -0.61 4e-29 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04841405 chr16:1501118 CLCN7 -0.57 -6.5 -0.37 3.9e-10 Gut microbiome composition (summer); CESC cis rs12142240 0.692 rs7529674 chr1:46818508 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs4555082 0.915 rs28594491 chr14:105758018 G/A cg13114125 chr14:105738426 BRF1 -0.88 -10.96 -0.56 2.66e-23 Mean platelet volume;Platelet distribution width; CESC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.01 9.29 0.5 5.83e-18 Platelet count; CESC cis rs9815354 0.812 rs17215589 chr3:41831203 C/T cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9467773 0.523 rs2498399 chr6:26706544 T/C cg26531700 chr6:26746687 NA -0.4 -5.87 -0.34 1.31e-8 Intelligence (multi-trait analysis); CESC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg25036284 chr2:26402008 FAM59B -0.59 -6.94 -0.39 3e-11 Gut microbiome composition (summer); CESC cis rs8114671 0.935 rs6142313 chr20:33780427 A/G cg06115741 chr20:33292138 TP53INP2 -0.42 -5.12 -0.3 6.02e-7 Height; CESC cis rs1178968 1.000 rs4717085 chr7:72764807 C/T cg25889504 chr7:72793014 NA 0.48 5.06 0.3 7.68e-7 Triglyceride levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16632891 chr1:54872978 SSBP3 -0.48 -7.04 -0.4 1.68e-11 Gambling; CESC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs2797160 0.905 rs1418640 chr6:125999866 G/A cg05901451 chr6:126070800 HEY2 -0.45 -6.67 -0.38 1.44e-10 Endometrial cancer; CESC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg18337363 chr3:52569053 NT5DC2 0.29 5.26 0.31 3.02e-7 Bipolar disorder; CESC cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg03433033 chr1:76189801 ACADM 0.64 7.52 0.42 8.38e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9640161 0.789 rs1464753 chr7:150021350 G/C cg10018233 chr7:150070692 REPIN1 0.43 6.83 0.39 5.68e-11 Blood protein levels;Circulating chemerin levels; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg13950250 chr8:104430401 DCAF13 0.47 6.58 0.37 2.56e-10 Thyroid stimulating hormone; CESC trans rs2727020 0.724 rs4109837 chr11:49372051 A/T cg03929089 chr4:120376271 NA -0.67 -7.86 -0.43 9.42e-14 Coronary artery disease; CESC cis rs12995491 0.902 rs6737641 chr2:88529471 A/T cg14558114 chr2:88469736 THNSL2 -0.49 -7.1 -0.4 1.13e-11 Response to metformin (IC50); CESC cis rs1878931 0.555 rs27228 chr16:3431933 C/T cg02880119 chr16:3481970 NA 0.45 5.35 0.31 1.92e-7 Body mass index (adult); CESC cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg20891283 chr12:69753455 YEATS4 0.9 14.98 0.68 3.6e-37 Blood protein levels; CESC cis rs7116495 0.588 rs547208 chr11:71779668 A/G cg10381502 chr11:71823885 C11orf51 -0.68 -5.44 -0.32 1.2e-7 Severe influenza A (H1N1) infection; CESC cis rs5995756 0.736 rs5995755 chr22:39999013 A/G cg03390717 chr22:39966585 CACNA1I -0.33 -5.81 -0.34 1.8e-8 Autism spectrum disorder or schizophrenia; CESC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg18876405 chr7:65276391 NA 0.5 6.48 0.37 4.33e-10 Aortic root size; CESC cis rs7666738 0.515 rs13131874 chr4:98779183 A/G cg05340658 chr4:99064831 C4orf37 0.54 6.59 0.38 2.39e-10 Colonoscopy-negative controls vs population controls; CESC cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg25554036 chr4:6271136 WFS1 0.56 8.86 0.48 1.18e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs67311347 0.544 rs2278927 chr3:40350447 G/A cg09455208 chr3:40491958 NA 0.35 6.3 0.36 1.24e-9 Renal cell carcinoma; CESC cis rs4713675 0.565 rs4713670 chr6:33699882 C/T cg15676125 chr6:33679581 C6orf125 -0.33 -5.03 -0.3 9.07e-7 Plateletcrit; CESC cis rs863345 0.565 rs10908668 chr1:158501933 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.76 -0.38 8.6e-11 Pneumococcal bacteremia; CESC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg07343612 chr16:622815 PIGQ -0.54 -7.79 -0.43 1.54e-13 Height; CESC cis rs11997175 0.574 rs872489 chr8:33646401 T/C ch.8.33884649F chr8:33765107 NA 0.65 8.33 0.46 4.44e-15 Body mass index; CESC cis rs595982 0.527 rs17206707 chr19:49361441 A/C cg15549821 chr19:49342101 PLEKHA4 -0.71 -7.95 -0.44 5.23e-14 Red cell distribution width; CESC cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg25019033 chr10:957182 NA -0.56 -5.57 -0.32 6.34e-8 Eosinophil percentage of granulocytes; CESC cis rs2204008 0.837 rs11168341 chr12:37961951 C/T cg26384229 chr12:38710491 ALG10B 0.75 11.23 0.57 3.47e-24 Bladder cancer; CESC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg04518342 chr5:131593106 PDLIM4 0.36 5.07 0.3 7.43e-7 Acylcarnitine levels; CESC cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg05340658 chr4:99064831 C4orf37 0.76 11.29 0.57 2.18e-24 Colonoscopy-negative controls vs population controls; CESC cis rs1878931 0.597 rs2680221 chr16:3462595 A/G cg22508957 chr16:3507546 NAT15 0.4 5.2 0.3 4e-7 Body mass index (adult); CESC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg00784671 chr22:46762841 CELSR1 -0.48 -5.59 -0.32 5.77e-8 LDL cholesterol;Cholesterol, total; CESC cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg20503657 chr10:835505 NA 1.09 9.95 0.52 4.95e-20 Eosinophil percentage of granulocytes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18585107 chr11:64138839 RPS6KA4 0.49 6.37 0.36 8.12e-10 Fibrinogen levels; CESC trans rs208520 0.739 rs1935894 chr6:66891434 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -11.15 -0.57 6.51e-24 Exhaled nitric oxide output; CESC cis rs7523050 0.730 rs67312582 chr1:109423976 A/G cg08274380 chr1:109419600 GPSM2 0.91 6.41 0.37 6.51e-10 Fat distribution (HIV); CESC cis rs1670533 1.000 rs6852850 chr4:1052857 C/G cg27284194 chr4:1044797 NA 0.46 5.83 0.34 1.6e-8 Recombination rate (females); CESC cis rs9325144 0.555 rs1825806 chr12:38692547 G/A cg26384229 chr12:38710491 ALG10B 0.58 8.47 0.46 1.67e-15 Morning vs. evening chronotype; CESC cis rs4588572 0.537 rs7705718 chr5:77730349 T/C cg11547950 chr5:77652471 NA -0.39 -5.31 -0.31 2.36e-7 Triglycerides; CESC cis rs9948 1.000 rs72811627 chr2:97517749 C/A cg01990225 chr2:97406019 LMAN2L -0.76 -5.41 -0.32 1.43e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs2795502 0.938 rs3121281 chr10:43400753 A/G cg27426351 chr10:43362370 NA 0.49 5.97 0.34 7.63e-9 Blood protein levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16221875 chr6:21588597 NA -0.45 -6.24 -0.36 1.76e-9 Gambling; CESC cis rs1953600 0.645 rs2573351 chr10:81931441 A/G cg00277334 chr10:82204260 NA -0.57 -8.34 -0.46 4.09e-15 Sarcoidosis; CESC cis rs2760061 0.819 rs1745416 chr1:228204497 G/A cg02753203 chr1:228287806 NA 0.53 7.86 0.43 9.88e-14 Diastolic blood pressure; CESC cis rs2481665 0.904 rs2457817 chr1:62604570 T/C cg18591186 chr1:62594603 INADL -0.52 -6.21 -0.36 2.07e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10771431 0.713 rs17794353 chr12:9361783 C/T cg08997352 chr12:9597637 DDX12 0.72 10.21 0.53 7.38e-21 Breast size; CESC cis rs10908458 0.584 rs10908455 chr1:155067283 C/T cg27045062 chr1:155054711 EFNA3 -0.37 -5.04 -0.3 8.49e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10791323 0.569 rs2156680 chr11:133742292 T/G cg15485101 chr11:133734466 NA 0.3 5.22 0.31 3.56e-7 Childhood ear infection; CESC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 5.91 0.34 1.06e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs6089829 0.855 rs6062781 chr20:61667128 G/A cg23505145 chr19:12996616 KLF1 0.52 6.8 0.39 6.85e-11 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.7.1578169F chr7:72409005 POM121 -0.58 -7.09 -0.4 1.25e-11 Gut microbiome composition (summer); CESC cis rs9457247 0.967 rs86755 chr6:167403108 T/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.32 -0.46 4.54e-15 Crohn's disease; CESC cis rs60843830 0.662 rs6721594 chr2:305203 C/T cg25945732 chr2:264204 ACP1;SH3YL1 -0.69 -9.09 -0.49 2.36e-17 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg00409905 chr10:38381863 ZNF37A -0.45 -6.04 -0.35 5.25e-9 Extrinsic epigenetic age acceleration; CESC cis rs936229 0.749 rs6495126 chr15:75175026 C/T cg14664628 chr15:75095509 CSK 0.73 9.39 0.5 2.94e-18 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.56 -5.54 -0.32 7.21e-8 Cerebrospinal P-tau181p levels; CESC trans rs9467711 0.659 rs35304979 chr6:26356347 C/A cg06606381 chr12:133084897 FBRSL1 -0.76 -6.87 -0.39 4.66e-11 Autism spectrum disorder or schizophrenia; CESC cis rs11792861 0.855 rs116127510 chr9:111868344 G/A cg05043794 chr9:111880884 C9orf5 -0.42 -6.93 -0.39 3.22e-11 Menarche (age at onset); CESC cis rs35740288 0.721 rs11636347 chr15:86241233 A/G cg20737812 chr15:86336631 KLHL25 -0.38 -5.1 -0.3 6.57e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs7177699 0.534 rs4387568 chr15:79109514 C/G cg04896959 chr15:78267971 NA 0.33 5.27 0.31 2.83e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg14829155 chr15:31115871 NA -0.65 -8.92 -0.48 7.84e-17 Huntington's disease progression; CESC cis rs8014204 0.935 rs10141438 chr14:75354600 A/G cg08847533 chr14:75593920 NEK9 -0.44 -5.4 -0.32 1.45e-7 Caffeine consumption; CESC cis rs8180040 0.620 rs9875235 chr3:47083621 G/A cg27129171 chr3:47204927 SETD2 0.66 9.82 0.52 1.32e-19 Colorectal cancer; CESC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.75e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs763121 0.853 rs3788544 chr22:39064966 C/T cg06022373 chr22:39101656 GTPBP1 0.85 12.82 0.62 1.3e-29 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14240963 chr22:36925312 EIF3D -0.5 -6.49 -0.37 4.23e-10 Fibrinogen levels; CESC cis rs12618769 0.597 rs4851140 chr2:99079339 T/C cg10123293 chr2:99228465 UNC50 0.39 5.17 0.3 4.69e-7 Bipolar disorder; CESC cis rs920590 0.758 rs2898491 chr8:19661883 C/T cg01411142 chr8:19674711 INTS10 0.52 5.86 0.34 1.39e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs453301 0.686 rs13252797 chr8:8861430 A/G cg15556689 chr8:8085844 FLJ10661 0.46 5.5 0.32 9e-8 Joint mobility (Beighton score); CESC cis rs6456156 0.586 rs2001114 chr6:167486578 A/G cg23791538 chr6:167370224 RNASET2 -0.54 -6.93 -0.39 3.1e-11 Primary biliary cholangitis; CESC cis rs9911578 0.935 rs2567912 chr17:56731270 T/C cg12560992 chr17:57184187 TRIM37 0.93 15.47 0.69 6.63e-39 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Depression; CESC cis rs728616 0.614 rs61859209 chr10:82128309 G/A cg05935833 chr10:81318306 SFTPA2 -0.45 -5.74 -0.33 2.59e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg11764359 chr7:65958608 NA -0.67 -8.67 -0.47 4.51e-16 Aortic root size; CESC cis rs9796 0.553 rs7171437 chr15:41315168 G/A cg18705301 chr15:41695430 NDUFAF1 -0.57 -7.96 -0.44 5.05e-14 Menopause (age at onset); CESC cis rs28647808 1.000 rs7031883 chr9:136276519 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg18876405 chr7:65276391 NA -0.53 -7.2 -0.4 6.41e-12 Aortic root size; CESC trans rs5756813 0.661 rs2246503 chr22:38204540 C/A cg19894588 chr14:64061835 NA -0.68 -8.45 -0.46 1.98e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.26 0.31 2.94e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3820068 0.603 rs72647120 chr1:15956769 G/T cg16988262 chr1:15930761 NA 0.34 5.49 0.32 9.2e-8 Systolic blood pressure; CESC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg11764359 chr7:65958608 NA 0.79 9.51 0.5 1.18e-18 Aortic root size; CESC cis rs8180040 0.620 rs6442055 chr3:47110722 A/G cg27129171 chr3:47204927 SETD2 0.69 10.02 0.52 3.07e-20 Colorectal cancer; CESC trans rs9397240 1.000 rs9397240 chr6:155648579 C/G cg05807698 chr11:118193562 NA -0.42 -6.17 -0.35 2.48e-9 Life satisfaction; CESC cis rs12477438 0.765 rs7605218 chr2:99593080 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.7 -0.47 3.67e-16 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22858966 chr12:89919202 WDR51B;GALNT4 0.67 7.98 0.44 4.53e-14 Gut microbiome composition (summer); CESC cis rs9399401 0.626 rs12664563 chr6:142785201 A/G cg03128060 chr6:142623767 GPR126 0.31 5.13 0.3 5.54e-7 Chronic obstructive pulmonary disease; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg18136715 chr10:79551995 DLG5 0.41 6.27 0.36 1.48e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg00149659 chr3:10157352 C3orf10 0.72 9.04 0.49 3.45e-17 Alzheimer's disease; CESC cis rs7605827 0.866 rs9710889 chr2:15533779 G/A cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs7208859 0.623 rs8081299 chr17:29104296 G/A cg13385521 chr17:29058706 SUZ12P 0.79 6.24 0.36 1.68e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg22823121 chr1:150693482 HORMAD1 0.46 6.33 0.36 1.02e-9 Melanoma; CESC cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg13175981 chr1:150552382 MCL1 0.72 10.77 0.55 1.17e-22 Tonsillectomy; CESC cis rs7429990 0.965 rs2053767 chr3:47999674 A/G cg11946769 chr3:48343235 NME6 0.44 5.37 0.31 1.76e-7 Educational attainment (years of education); CESC cis rs7615952 0.932 rs6438948 chr3:125650045 A/T cg05084668 chr3:125655381 ALG1L 0.5 5.97 0.34 7.43e-9 Blood pressure (smoking interaction); CESC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg23161317 chr6:28129485 ZNF389 0.49 6.63 0.38 1.85e-10 Parkinson's disease; CESC cis rs523522 0.962 rs10849757 chr12:120964014 G/A cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs11098499 0.954 rs10006525 chr4:120408931 T/G cg09307838 chr4:120376055 NA 0.95 13.85 0.65 3.54e-33 Corneal astigmatism; CESC trans rs875971 1.000 rs778696 chr7:65870813 C/G cg26939375 chr7:64535504 NA 0.47 6.14 0.35 3.07e-9 Aortic root size; CESC cis rs4237845 0.844 rs4628718 chr12:58301600 A/C cg00677455 chr12:58241039 CTDSP2 0.62 7.69 0.43 2.86e-13 Intelligence (multi-trait analysis); CESC cis rs4780401 0.609 rs4780399 chr16:11828701 A/T cg01061890 chr16:11836724 TXNDC11 -0.56 -7.71 -0.43 2.58e-13 Rheumatoid arthritis; CESC cis rs4704187 0.687 rs57646262 chr5:74527472 C/T cg03227963 chr5:74354835 NA 0.28 5.17 0.3 4.61e-7 Response to amphetamines; CESC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg00310523 chr12:86230176 RASSF9 -0.38 -5.81 -0.34 1.83e-8 Major depressive disorder; CESC cis rs644799 0.623 rs17207890 chr11:95490754 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.8 11.01 0.56 1.82e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg27170947 chr2:26402098 FAM59B -0.82 -9.61 -0.51 6.07e-19 Gut microbiome composition (summer); CESC cis rs7474896 0.515 rs688608 chr10:38331624 G/A cg25427524 chr10:38739819 LOC399744 0.52 5.4 0.31 1.49e-7 Obesity (extreme); CESC cis rs12422267 0.536 rs58521339 chr12:132609486 T/C cg09764611 chr12:132620959 NA -0.58 -6.91 -0.39 3.7e-11 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs72781680 0.898 rs55761273 chr2:23957849 A/G cg08917208 chr2:24149416 ATAD2B 0.96 8.67 0.47 4.28e-16 Lymphocyte counts; CESC cis rs7246657 0.550 rs10411176 chr19:37686953 G/T cg23950597 chr19:37808831 NA -0.61 -5.07 -0.3 7.36e-7 Coronary artery calcification; CESC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg08499158 chr17:42289980 UBTF 0.41 5.27 0.31 2.83e-7 Total body bone mineral density; CESC cis rs12971120 0.783 rs7229256 chr18:72169129 T/A cg26446133 chr18:72167187 CNDP2 -0.74 -11.03 -0.56 1.57e-23 Refractive error; CESC cis rs8180040 0.966 rs11719877 chr3:47425473 C/T cg27129171 chr3:47204927 SETD2 0.63 9.65 0.51 4.34e-19 Colorectal cancer; CESC cis rs6460942 0.908 rs3887296 chr7:12257966 A/G cg06484146 chr7:12443880 VWDE -0.55 -5.68 -0.33 3.58e-8 Coronary artery disease; CESC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC trans rs10411161 0.702 rs16983196 chr19:52384779 C/A cg22319618 chr22:45562946 NUP50 -0.71 -7.04 -0.4 1.66e-11 Breast cancer; CESC cis rs12220238 0.915 rs12217890 chr10:76024496 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.56 5.23 0.31 3.48e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs561341 1.000 rs506766 chr17:30289659 T/C cg12193833 chr17:30244370 NA -0.73 -6.39 -0.37 7.3e-10 Hip circumference adjusted for BMI; CESC cis rs929354 0.742 rs7785227 chr7:156999297 C/T cg05182265 chr7:156933206 UBE3C -0.51 -7.47 -0.42 1.2e-12 Body mass index; CESC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg06481639 chr22:41940642 POLR3H -0.58 -5.89 -0.34 1.16e-8 Vitiligo; CESC trans rs648516 0.765 rs9315568 chr13:38835360 C/T cg14728235 chr20:57415177 GNASAS;GNAS -0.33 -6.01 -0.35 6.14e-9 Schizophrenia; CESC cis rs6987853 0.787 rs2923405 chr8:42448126 T/G cg09913449 chr8:42400586 C8orf40 0.46 7.88 0.44 8.72e-14 Mean corpuscular hemoglobin concentration; CESC cis rs4253772 0.575 rs9615983 chr22:46793314 G/A cg24881330 chr22:46731750 TRMU 0.75 5.74 0.33 2.56e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7264396 0.563 rs2425138 chr20:34345710 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.9 -10.79 -0.55 9.97e-23 Total cholesterol levels; CESC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg15595755 chr5:1867978 NA 0.53 8.79 0.48 1.94e-16 Cardiovascular disease risk factors; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07332178 chr7:43798019 BLVRA -0.42 -6.01 -0.35 6.06e-9 Gambling; CESC cis rs9303401 0.659 rs34913878 chr17:56897094 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.68 0.61 4.11e-29 Cognitive test performance; CESC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg03351412 chr1:154909251 PMVK 0.69 9.39 0.5 2.91e-18 Prostate cancer; CESC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg05872129 chr22:39784769 NA -0.88 -10.85 -0.55 6.08e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13309018 chr9:130965761 CIZ1;DNM1 -0.45 -6.43 -0.37 6.05e-10 Gambling; CESC cis rs910316 1.000 rs9805979 chr14:75566209 G/A cg11812906 chr14:75593930 NEK9 0.89 15.08 0.68 1.6e-37 Height; CESC cis rs2066819 1.000 rs2306693 chr12:56680531 T/C cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg27121462 chr16:89883253 FANCA -0.6 -7.97 -0.44 4.76e-14 Vitiligo; CESC cis rs1348850 0.632 rs13008833 chr2:178514439 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.68 0.43 3.1e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6088590 1.000 rs11698977 chr20:33449691 C/T cg06115741 chr20:33292138 TP53INP2 0.62 7.76 0.43 1.81e-13 Coronary artery disease; CESC cis rs561341 0.714 rs55925849 chr17:30253085 C/T cg12193833 chr17:30244370 NA -0.76 -6.85 -0.39 5.14e-11 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19133618 chr9:22008970 CDKN2B;CDKN2BAS 0.52 6.08 0.35 4.15e-9 Gut microbiome composition (summer); CESC cis rs2404602 0.647 rs12905181 chr15:77098431 A/G cg23625390 chr15:77176239 SCAPER -0.47 -6.51 -0.37 3.72e-10 Blood metabolite levels; CESC cis rs11098499 0.562 rs58583086 chr4:120556362 A/G cg09307838 chr4:120376055 NA -0.64 -8.6 -0.47 6.94e-16 Corneal astigmatism; CESC cis rs7953249 0.656 rs2178463 chr12:121389721 A/G cg02403541 chr12:121454288 C12orf43 -0.52 -6.82 -0.39 6.14e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs9325144 0.505 rs7955162 chr12:38711658 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.63 0.38 1.91e-10 Morning vs. evening chronotype; CESC cis rs9926296 0.682 rs258328 chr16:89730314 C/T cg27121462 chr16:89883253 FANCA -0.48 -5.78 -0.33 2.13e-8 Vitiligo; CESC cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg05343316 chr1:45956843 TESK2 -0.51 -6.75 -0.38 9.56e-11 High light scatter reticulocyte count; CESC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.17 0.49 1.32e-17 Menopause (age at onset); CESC cis rs2742234 0.541 rs1254958 chr10:43702143 C/T cg07801480 chr10:43725741 RASGEF1A -0.41 -5.33 -0.31 2.14e-7 Hirschsprung disease; CESC trans rs347313 1.000 rs347281 chr1:162313037 C/A cg16315582 chr11:104839349 CASP4 -0.43 -6.09 -0.35 3.85e-9 Body mass index (change over time); CESC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg22800045 chr5:56110881 MAP3K1 0.81 9.96 0.52 4.58e-20 Initial pursuit acceleration; CESC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg25036284 chr2:26402008 FAM59B -0.86 -9.4 -0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs4727027 0.933 rs10277119 chr7:148849942 T/C cg23158103 chr7:148848205 ZNF398 -0.41 -6.56 -0.37 2.83e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6088580 0.524 rs6088560 chr20:33228549 T/C cg24642439 chr20:33292090 TP53INP2 -0.45 -5.26 -0.31 2.96e-7 Glomerular filtration rate (creatinine); CESC cis rs9486719 0.895 rs12190520 chr6:96928620 A/C cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.45e-15 Migraine;Coronary artery disease; CESC cis rs9611565 0.592 rs1811113 chr22:42073134 C/T cg17376030 chr22:41985996 PMM1 -0.79 -8.55 -0.47 9.65e-16 Vitiligo; CESC cis rs34779708 0.966 rs12257770 chr10:35517234 A/G cg03585969 chr10:35415529 CREM 0.67 8.37 0.46 3.26e-15 Inflammatory bowel disease;Crohn's disease; CESC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg13126279 chr21:47581558 C21orf56 -0.49 -6.64 -0.38 1.77e-10 Testicular germ cell tumor; CESC cis rs4727963 0.755 rs6943941 chr7:122705651 G/A cg03640110 chr7:122635026 TAS2R16 -0.4 -6.26 -0.36 1.58e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.64 0.77 1.26e-53 Height; CESC cis rs1707322 0.896 rs785512 chr1:46534543 A/G cg05343316 chr1:45956843 TESK2 -0.44 -5.26 -0.31 2.94e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11098499 0.863 rs11098531 chr4:120465001 G/A cg09307838 chr4:120376055 NA 0.91 12.73 0.62 2.82e-29 Corneal astigmatism; CESC cis rs7474896 0.583 rs4934898 chr10:37990395 G/C cg00409905 chr10:38381863 ZNF37A -0.48 -5.53 -0.32 7.85e-8 Obesity (extreme); CESC cis rs9325144 0.647 rs11168741 chr12:38989120 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.33 -0.41 2.83e-12 Morning vs. evening chronotype; CESC cis rs1904096 0.506 rs13434570 chr4:95168019 T/C cg11021082 chr4:95130006 SMARCAD1 -0.68 -11.1 -0.56 9.37e-24 Type 2 diabetes; CESC cis rs36051895 0.623 rs6476952 chr9:5236924 T/C cg02405213 chr9:5042618 JAK2 -0.57 -7.07 -0.4 1.35e-11 Pediatric autoimmune diseases; CESC cis rs938554 0.692 rs13111638 chr4:9996890 A/G cg11266682 chr4:10021025 SLC2A9 0.47 5.81 0.34 1.76e-8 Blood metabolite levels; CESC cis rs116095464 0.614 rs28736753 chr5:274081 G/A cg10591111 chr5:226296 SDHA -0.56 -6.71 -0.38 1.18e-10 Breast cancer; CESC cis rs6088590 0.930 rs6120723 chr20:33364655 C/T cg06115741 chr20:33292138 TP53INP2 0.59 7.27 0.41 4.05e-12 Coronary artery disease; CESC cis rs9611565 0.649 rs202645 chr22:41798520 A/G cg06634786 chr22:41940651 POLR3H 0.74 7.68 0.43 3.08e-13 Vitiligo; CESC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg22143856 chr6:28129313 ZNF389 0.42 5.26 0.31 2.91e-7 Parkinson's disease; CESC cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.89 0.34 1.15e-8 Hip circumference adjusted for BMI; CESC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg10691866 chr7:65817282 TPST1 -0.34 -5.59 -0.32 5.57e-8 Aortic root size; CESC cis rs6460942 1.000 rs6460935 chr7:12401317 A/T cg13733410 chr7:12443478 VWDE -0.54 -5.35 -0.31 1.9e-7 Coronary artery disease; CESC cis rs6831352 0.918 rs2602893 chr4:100044095 G/T cg13256891 chr4:100009986 ADH5 0.74 8.21 0.45 9.57e-15 Alcohol dependence; CESC cis rs910316 1.000 rs12589876 chr14:75544189 G/A cg08847533 chr14:75593920 NEK9 1.0 19.05 0.76 1.49e-51 Height; CESC cis rs17039065 0.920 rs7674961 chr4:109440528 G/A cg16022748 chr4:109541635 LOC285456;RPL34 0.67 6.4 0.37 7.14e-10 Gut microbiome composition (summer); CESC trans rs208520 0.690 rs12208977 chr6:66725257 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.24 0.6 1.32e-27 Exhaled nitric oxide output; CESC cis rs9309473 0.607 rs10198301 chr2:73581600 T/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.22 -0.36 1.92e-9 Metabolite levels; CESC cis rs870825 0.587 rs35845099 chr4:185639762 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg17724175 chr1:150552817 MCL1 0.4 6.13 0.35 3.2e-9 Melanoma; CESC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg19163074 chr7:65112434 INTS4L2 -0.43 -5.34 -0.31 2e-7 Aortic root size; CESC cis rs6915183 1.000 rs6919988 chr6:166706319 T/A cg14022523 chr6:166756177 SFT2D1 0.57 7.5 0.42 9.76e-13 Longevity; CESC cis rs7635838 0.819 rs4684781 chr3:11516299 G/A cg00170343 chr3:11313890 ATG7 0.42 5.65 0.33 4.07e-8 HDL cholesterol; CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg27094323 chr7:1216898 NA -0.4 -5.49 -0.32 9.19e-8 Longevity;Endometriosis; CESC cis rs763014 0.865 rs4006748 chr16:632225 T/C cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg05340658 chr4:99064831 C4orf37 0.77 11.22 0.57 3.61e-24 Colonoscopy-negative controls vs population controls; CESC cis rs7116495 1.000 rs11235440 chr11:71826644 A/G cg10381502 chr11:71823885 C11orf51 0.66 5.6 0.33 5.26e-8 Severe influenza A (H1N1) infection; CESC cis rs4822044 0.560 rs7284839 chr22:42010902 C/T cg03806693 chr22:41940476 POLR3H 1.08 12.76 0.62 2.14e-29 Cannabis dependence symptom count; CESC cis rs2985684 0.789 rs1957979 chr14:50063332 A/G cg04989706 chr14:50066350 PPIL5 -0.46 -5.15 -0.3 5.08e-7 Carotid intima media thickness; CESC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg06481639 chr22:41940642 POLR3H 0.59 5.84 0.34 1.51e-8 Vitiligo; CESC cis rs367943 0.966 rs348945 chr5:112822889 C/T cg12552261 chr5:112820674 MCC -0.63 -7.96 -0.44 4.96e-14 Type 2 diabetes; CESC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs6964587 0.626 rs10280301 chr7:91524258 A/T cg17063962 chr7:91808500 NA -0.46 -6.48 -0.37 4.55e-10 Breast cancer; CESC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg02569458 chr12:86230093 RASSF9 0.57 8.39 0.46 3e-15 Major depressive disorder; CESC trans rs7246657 0.882 rs59224125 chr19:37963205 T/C cg01833234 chr11:6592585 DNHD1 0.52 6.0 0.35 6.5e-9 Coronary artery calcification; CESC cis rs6540559 0.546 rs75308488 chr1:210030639 T/C cg25204440 chr1:209979598 IRF6 0.66 5.89 0.34 1.19e-8 Cleft lip with or without cleft palate; CESC cis rs2645694 0.626 rs2645705 chr4:77830434 G/A cg10057126 chr4:77819792 ANKRD56 0.6 8.45 0.46 1.91e-15 Emphysema distribution in smoking; CESC cis rs2439831 1.000 rs2264239 chr15:43765533 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.56 0.54 5.46e-22 Lung cancer in ever smokers; CESC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.43 0.37 5.84e-10 Bipolar disorder; CESC cis rs7923452 1.000 rs7923452 chr10:30751171 T/C cg18806716 chr10:30721971 MAP3K8 0.51 6.08 0.35 4.28e-9 Itch intensity from mosquito bite; CESC cis rs72901758 0.768 rs11650317 chr17:76251306 A/T cg26068271 chr17:76253126 NA 0.47 6.64 0.38 1.76e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs6466055 0.720 rs1121194 chr7:104981133 T/C cg04380332 chr7:105027541 SRPK2 0.4 5.43 0.32 1.29e-7 Schizophrenia; CESC cis rs847577 0.722 rs1013886 chr7:97709861 A/G cg24562669 chr7:97807699 LMTK2 -0.64 -10.42 -0.54 1.58e-21 Breast cancer; CESC cis rs6460942 0.908 rs117451929 chr7:12265149 A/T cg20607287 chr7:12443886 VWDE -0.6 -6.3 -0.36 1.21e-9 Coronary artery disease; CESC trans rs74054849 0.850 rs72878901 chr1:16023530 G/A cg06826283 chr7:600452 PRKAR1B 0.69 6.14 0.35 3e-9 Alcoholic chronic pancreatitis; CESC cis rs6496667 1.000 rs6496667 chr15:90893668 C/A cg22089800 chr15:90895588 ZNF774 0.56 5.62 0.33 4.73e-8 Rheumatoid arthritis; CESC cis rs703842 1.000 rs10431505 chr12:58178589 A/G cg00599273 chr12:58146742 CDK4 0.34 5.11 0.3 6.1e-7 Multiple sclerosis; CESC cis rs4629180 0.675 rs4851459 chr2:102109006 T/A cg04415270 chr2:102091202 RFX8 -0.3 -5.28 -0.31 2.66e-7 Chronic rhinosinusitis with nasal polyps; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23497857 chr14:24685372 MDP1 -0.43 -6.12 -0.35 3.29e-9 Gut microbiota (bacterial taxa); CESC cis rs10504229 0.679 rs72649132 chr8:58054615 G/A cg21724239 chr8:58056113 NA 0.52 5.05 0.3 8.08e-7 Developmental language disorder (linguistic errors); CESC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg23281280 chr6:28129359 ZNF389 0.5 6.56 0.37 2.75e-10 Parkinson's disease; CESC cis rs7193541 0.585 rs3851729 chr16:74485529 A/G cg01733217 chr16:74700730 RFWD3 -0.84 -13.27 -0.63 3.78e-31 Multiple myeloma; CESC cis rs1124376 0.935 rs12490215 chr3:20156185 A/G cg05072819 chr3:20081367 KAT2B 0.47 5.52 0.32 7.96e-8 Bipolar disorder and schizophrenia; CESC cis rs2832191 0.647 rs11170 chr21:30378090 C/T cg24692254 chr21:30365293 RNF160 0.97 16.48 0.71 1.71e-42 Dental caries; CESC cis rs9911578 0.765 rs66954617 chr17:56999427 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.31 0.31 2.27e-7 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15216636 chr19:6739886 TRIP10 -0.51 -6.96 -0.39 2.74e-11 Gut microbiota (bacterial taxa); CESC cis rs10911251 0.528 rs10911264 chr1:183115040 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.8 0.65 5.11e-33 Colorectal cancer; CESC cis rs977987 0.705 rs4888377 chr16:75325686 C/G cg03315344 chr16:75512273 CHST6 0.39 5.26 0.31 3.01e-7 Dupuytren's disease; CESC cis rs7429990 0.965 rs7430879 chr3:48038714 C/T cg11946769 chr3:48343235 NME6 -0.44 -5.38 -0.31 1.63e-7 Educational attainment (years of education); CESC cis rs2014572 0.967 rs8106734 chr19:57763546 C/T cg24459738 chr19:57751996 ZNF805 -0.52 -7.47 -0.42 1.17e-12 Hyperactive-impulsive symptoms; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg08198330 chr19:15483731 AKAP8 0.49 6.06 0.35 4.68e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs4803468 1.000 rs6508977 chr19:41909346 A/G cg09537434 chr19:41945824 ATP5SL -1.04 -18.7 -0.75 2.39e-50 Height; CESC cis rs4803468 1.000 rs878082 chr19:41897674 G/A cg14132834 chr19:41945861 ATP5SL -0.56 -6.89 -0.39 4.02e-11 Height; CESC cis rs2832077 0.527 rs2250141 chr21:30241984 A/T cg08807101 chr21:30365312 RNF160 0.52 6.32 0.36 1.08e-9 Cognitive test performance; CESC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg14393609 chr7:65229607 NA -0.44 -5.89 -0.34 1.14e-8 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16907669 chr6:3064109 NA -0.43 -6.11 -0.35 3.48e-9 Gambling; CESC cis rs35520189 0.556 rs13026837 chr2:113705673 G/A cg06156847 chr2:113672199 IL1F7 0.37 5.31 0.31 2.3e-7 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs3106136 0.934 rs34396188 chr4:95191292 A/C cg11021082 chr4:95130006 SMARCAD1 -0.37 -5.28 -0.31 2.71e-7 Capecitabine sensitivity; CESC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg11890956 chr21:40555474 PSMG1 -0.52 -6.78 -0.38 7.82e-11 Cognitive function; CESC cis rs4727027 0.704 rs2269972 chr7:148914047 C/T cg23158103 chr7:148848205 ZNF398 0.33 5.21 0.3 3.82e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2933343 0.621 rs4927921 chr3:128568868 A/G cg25356066 chr3:128598488 ACAD9 -0.61 -8.54 -0.46 1.06e-15 IgG glycosylation; CESC cis rs478304 0.654 rs7934036 chr11:65451020 G/T cg27068330 chr11:65405492 SIPA1 -0.4 -5.06 -0.3 7.68e-7 Acne (severe); CESC cis rs2072732 0.904 rs9661525 chr1:2952840 A/C cg03976712 chr1:2946727 NA 0.35 5.74 0.33 2.56e-8 Plateletcrit; CESC cis rs4835473 0.900 rs35395070 chr4:144693436 T/C cg25736465 chr4:144833511 NA -0.33 -5.15 -0.3 5e-7 Immature fraction of reticulocytes; CESC cis rs8072100 0.777 rs9914653 chr17:45537395 T/C cg25173405 chr17:45401733 C17orf57 -0.43 -5.76 -0.33 2.39e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7829975 0.840 rs555617 chr8:8592845 C/G cg15556689 chr8:8085844 FLJ10661 -0.44 -5.49 -0.32 9.49e-8 Mood instability; CESC cis rs9399137 0.507 rs11758774 chr6:135383789 T/G cg22676075 chr6:135203613 NA 0.53 6.88 0.39 4.41e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs2108622 0.727 rs7254940 chr19:15984508 C/T cg13772218 chr19:15982569 NA 0.3 5.96 0.34 7.91e-9 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs3126085 0.935 rs10888471 chr1:152200849 G/T cg03465714 chr1:152285911 FLG 0.41 5.19 0.3 4.26e-7 Atopic dermatitis; CESC cis rs79349575 0.783 rs62075818 chr17:46982327 T/A cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs2014572 0.967 rs10412975 chr19:57770554 C/A cg12963866 chr19:57752005 ZNF805 -0.49 -6.54 -0.37 3.17e-10 Hyperactive-impulsive symptoms; CESC cis rs2070488 0.965 rs9877282 chr3:38541452 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.94 -17.61 -0.73 1.79e-46 Electrocardiographic conduction measures; CESC cis rs13082711 0.554 rs6804440 chr3:27398150 C/T cg02860705 chr3:27208620 NA 0.76 8.61 0.47 6.59e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15238519 chr22:50683529 TUBGCP6 0.6 7.21 0.4 5.82e-12 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.3 0.36 1.21e-9 Menopause (age at onset); CESC cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg24110177 chr3:50126178 RBM5 0.51 6.95 0.39 2.75e-11 Intelligence (multi-trait analysis); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24368588 chr20:61903974 ARFGAP1 -0.46 -6.18 -0.35 2.42e-9 Ulcerative colitis; CESC cis rs7927771 1.000 rs12421210 chr11:47779586 C/T cg18512352 chr11:47633146 NA -0.61 -9.63 -0.51 5.17e-19 Subjective well-being; CESC cis rs1023500 0.505 rs134874 chr22:42661144 A/G cg04733989 chr22:42467013 NAGA 0.64 9.52 0.5 1.13e-18 Schizophrenia; CESC cis rs601339 1.000 rs525215 chr12:123179771 G/A cg11919336 chr12:123188078 GPR109A 0.48 6.44 0.37 5.44e-10 Adiponectin levels; CESC trans rs73568641 0.583 rs73570675 chr6:154077590 T/A cg08374472 chr16:87445639 ZCCHC14 -0.46 -6.12 -0.35 3.26e-9 Methadone dose in opioid dependence; CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg07092213 chr7:1199455 ZFAND2A -0.52 -6.12 -0.35 3.44e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11039798 0.507 rs56994343 chr11:48896970 G/A cg15704280 chr7:45808275 SEPT13 0.64 6.59 0.38 2.31e-10 Axial length; CESC cis rs2073300 0.609 rs1076776 chr20:23427399 C/T cg12062639 chr20:23401060 NAPB -0.96 -7.71 -0.43 2.5e-13 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs10504229 0.679 rs4737454 chr8:58033965 A/T cg22535103 chr8:58192502 C8orf71 -0.57 -6.56 -0.37 2.78e-10 Developmental language disorder (linguistic errors); CESC cis rs7598759 0.712 rs6727510 chr2:232332016 T/C cg19187155 chr2:232395269 NMUR1 0.39 6.12 0.35 3.36e-9 Noise-induced hearing loss; CESC cis rs9916302 0.851 rs12936996 chr17:37665554 A/G cg15445000 chr17:37608096 MED1 -0.4 -6.72 -0.38 1.1e-10 Glomerular filtration rate (creatinine); CESC cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg01475377 chr6:109611718 NA -0.5 -8.14 -0.45 1.55e-14 Reticulocyte fraction of red cells; CESC cis rs11098499 0.863 rs6853998 chr4:120475860 C/A cg09307838 chr4:120376055 NA 0.9 12.45 0.61 2.6e-28 Corneal astigmatism; CESC cis rs7772486 0.686 rs9390347 chr6:146044747 G/T cg23711669 chr6:146136114 FBXO30 -0.87 -12.9 -0.62 7e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg14983838 chr19:29218262 NA 0.47 5.9 0.34 1.09e-8 Methadone dose in opioid dependence; CESC cis rs7546094 1.000 rs902289 chr1:113236087 C/T cg22162597 chr1:113214053 CAPZA1 -0.38 -5.88 -0.34 1.22e-8 Platelet distribution width; CESC cis rs3126085 0.935 rs4845423 chr1:152184950 T/G cg03465714 chr1:152285911 FLG -0.42 -5.14 -0.3 5.24e-7 Atopic dermatitis; CESC cis rs67311347 1.000 rs12108041 chr3:40487535 C/T cg24209194 chr3:40518798 ZNF619 0.5 6.16 0.35 2.72e-9 Renal cell carcinoma; CESC trans rs66573146 0.572 rs73199995 chr4:6955801 G/C cg07817883 chr1:32538562 TMEM39B 1.25 8.67 0.47 4.31e-16 Granulocyte percentage of myeloid white cells; CESC cis rs3736485 0.966 rs10220909 chr15:51762412 C/A cg08986416 chr15:51914746 DMXL2 -0.41 -5.28 -0.31 2.69e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9486719 1.000 rs2142653 chr6:96871520 C/A cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs10411936 0.682 rs8103805 chr19:16598433 T/G cg10248733 chr19:16607483 C19orf44;CALR3 0.58 6.85 0.39 5.22e-11 White blood cell count;Multiple sclerosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09717923 chr16:1440498 NA 0.43 6.29 0.36 1.29e-9 Fibrinogen levels; CESC cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg11663144 chr21:46675770 NA -0.43 -6.43 -0.37 5.97e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg03929089 chr4:120376271 NA 0.84 12.34 0.6 5.97e-28 Height; CESC cis rs35110281 0.681 rs162343 chr21:44957072 A/G cg21573476 chr21:45109991 RRP1B -0.42 -6.01 -0.35 6.09e-9 Mean corpuscular volume; CESC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg21724239 chr8:58056113 NA 0.57 5.76 0.33 2.29e-8 Developmental language disorder (linguistic errors); CESC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg14393609 chr7:65229607 NA -0.45 -5.97 -0.34 7.78e-9 Aortic root size; CESC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg07677032 chr17:61819896 STRADA 0.46 6.1 0.35 3.83e-9 Prudent dietary pattern; CESC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg11644478 chr21:40555479 PSMG1 -0.57 -7.9 -0.44 7.71e-14 Menarche (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13169780 chr17:7591570 TP53;WRAP53 0.44 6.28 0.36 1.42e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg05025164 chr4:1340916 KIAA1530 0.65 8.87 0.48 1.09e-16 Longevity; CESC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.46 0.42 1.23e-12 Tonsillectomy; CESC cis rs2075371 0.501 rs1646653 chr7:134024686 A/G cg20476274 chr7:133979776 SLC35B4 0.41 5.11 0.3 6.13e-7 Mean platelet volume; CESC cis rs62064224 0.702 rs2302277 chr17:30791509 C/G cg12855166 chr17:30846586 MYO1D 0.4 5.11 0.3 6.32e-7 Schizophrenia; CESC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg17971929 chr21:40555470 PSMG1 1.08 16.28 0.71 9.03e-42 Cognitive function; CESC cis rs7772486 0.875 rs7766595 chr6:146364507 A/T cg23711669 chr6:146136114 FBXO30 0.83 12.12 0.6 3.46e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs7914558 0.869 rs10883842 chr10:104941589 C/T cg04362960 chr10:104952993 NT5C2 0.47 6.21 0.36 2.01e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2115536 0.967 rs934137 chr15:80211768 T/C cg00225070 chr15:80189496 MTHFS 0.54 7.36 0.41 2.36e-12 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs10911232 0.507 rs10911199 chr1:182998036 T/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg07648498 chr16:89883185 FANCA -0.46 -6.0 -0.35 6.29e-9 Vitiligo; CESC cis rs6547741 1.000 rs2384654 chr2:27847364 C/T cg27432699 chr2:27873401 GPN1 0.49 6.95 0.39 2.84e-11 Oral cavity cancer; CESC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg11494091 chr17:61959527 GH2 0.75 13.31 0.63 2.77e-31 Prudent dietary pattern; CESC cis rs116095464 0.619 rs2303741 chr5:218356 T/C cg10591111 chr5:226296 SDHA -0.51 -6.35 -0.36 9.22e-10 Breast cancer; CESC cis rs10465746 0.746 rs6699501 chr1:84389993 A/G cg10977910 chr1:84465055 TTLL7 0.5 6.8 0.39 6.77e-11 Obesity-related traits; CESC cis rs867529 0.600 rs335120 chr2:89072731 A/G cg26627705 chr2:89060884 NA 0.36 5.12 0.3 5.76e-7 Height; CESC cis rs2929278 0.617 rs694461 chr15:44096063 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.55 -7.31 -0.41 3.12e-12 Schizophrenia; CESC cis rs6121246 0.559 rs6087779 chr20:30370566 T/C cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00265317 chr16:70472993 ST3GAL2 0.61 7.17 0.4 7.29e-12 Gut microbiome composition (summer); CESC cis rs919433 0.783 rs787979 chr2:198242868 A/T cg20885578 chr2:198174922 NA 0.4 5.3 0.31 2.5e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7267979 1.000 rs2482911 chr20:25395528 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -16.45 -0.71 2.19e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs9902453 0.935 rs9898424 chr17:28392946 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.11e-13 Coffee consumption (cups per day); CESC cis rs12545109 0.765 rs1960727 chr8:57411368 G/A cg09654669 chr8:57350985 NA -0.54 -6.35 -0.36 9.45e-10 Obesity-related traits; CESC cis rs1008375 0.898 rs10008445 chr4:17593978 G/T cg02297831 chr4:17616191 MED28 0.51 6.27 0.36 1.43e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2072732 0.861 rs2993479 chr1:2967039 A/T cg15211996 chr1:2936768 ACTRT2 0.31 5.65 0.33 4.22e-8 Plateletcrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24367984 chr17:1945160 OVCA2;DPH1 0.58 6.88 0.39 4.37e-11 Gut microbiome composition (summer); CESC trans rs17685 0.753 rs4732542 chr7:75663203 A/G cg19862616 chr7:65841803 NCRNA00174 0.79 11.49 0.58 4.78e-25 Coffee consumption;Coffee consumption (cups per day); CESC cis rs3806843 0.735 rs702394 chr5:140086786 A/G cg26395211 chr5:140044315 WDR55 0.48 6.2 0.36 2.2e-9 Depressive symptoms (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09089653 chr5:134734307 H2AFY -0.57 -6.36 -0.36 8.61e-10 Gut microbiome composition (summer); CESC cis rs6430585 0.528 rs6750549 chr2:136707480 A/G cg07169764 chr2:136633963 MCM6 1.29 20.09 0.78 3.63e-55 Corneal structure; CESC cis rs5743618 0.537 rs6832466 chr4:38770543 A/G cg02016764 chr4:38805732 TLR1 -0.33 -5.16 -0.3 4.84e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs7772486 0.875 rs2207785 chr6:146332784 T/G cg05347473 chr6:146136440 FBXO30 0.51 6.72 0.38 1.12e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs12791968 0.659 rs12808379 chr11:45009273 C/G cg11846598 chr11:44996168 LOC221122 -0.49 -6.04 -0.35 5.16e-9 Inhibitory control; CESC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg27286337 chr10:134555280 INPP5A 0.63 7.32 0.41 3.03e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs5167 0.504 rs3760625 chr19:45456941 G/A cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.23e-14 Blood protein levels; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg14094063 chr7:140624470 BRAF -0.45 -6.07 -0.35 4.46e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs524023 0.914 rs80841 chr11:64437490 T/C cg19131476 chr11:64387923 NRXN2 -0.33 -5.03 -0.3 9e-7 Urate levels in obese individuals; CESC trans rs208520 0.690 rs866452 chr6:66849936 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -12.79 -0.62 1.72e-29 Exhaled nitric oxide output; CESC trans rs6570726 0.791 rs6914203 chr6:145899975 C/A cg03826317 chr10:25465503 LOC100128811;GPR158 0.31 6.15 0.35 2.91e-9 Lobe attachment (rater-scored or self-reported); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09312254 chr12:112450979 ERP29;TMEM116 -0.47 -6.49 -0.37 4.28e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs11098499 0.863 rs7669520 chr4:120515278 T/C cg24375607 chr4:120327624 NA 0.45 5.53 0.32 7.69e-8 Corneal astigmatism; CESC cis rs75804782 0.557 rs10178728 chr2:239360121 T/A cg18131467 chr2:239335373 ASB1 -0.62 -6.91 -0.39 3.61e-11 Morning vs. evening chronotype;Chronotype; CESC cis rs826838 1.000 rs11183469 chr12:38752311 G/A cg26384229 chr12:38710491 ALG10B 0.84 14.74 0.67 2.59e-36 Heart rate; CESC cis rs9308433 0.529 rs1391553 chr1:214474119 T/C cg06198575 chr1:214491504 SMYD2 0.49 5.84 0.34 1.54e-8 IgG glycosylation; CESC cis rs2204008 0.555 rs7310307 chr12:38107497 G/T cg26384229 chr12:38710491 ALG10B 0.72 10.07 0.53 2.16e-20 Bladder cancer; CESC cis rs4689388 0.926 rs6446480 chr4:6295565 C/T cg00701064 chr4:6280414 WFS1 0.66 11.07 0.56 1.2e-23 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs4129059 0.834 rs72759620 chr1:214684150 G/A cg08158662 chr12:34489995 NA 0.55 6.21 0.36 2e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs704 0.585 rs1007398 chr17:26665648 A/G cg10494684 chr17:26645200 TMEM97 -0.4 -5.52 -0.32 7.96e-8 Osteoprotegerin levels; CESC cis rs9303401 0.659 rs7225896 chr17:56637337 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.99 11.38 0.57 1.06e-24 Cognitive test performance; CESC cis rs11148252 0.532 rs9536185 chr13:53179801 G/A cg00495681 chr13:53174319 NA 0.67 9.0 0.48 4.57e-17 Lewy body disease; CESC cis rs10411936 0.692 rs10413787 chr19:16594967 A/G cg10248733 chr19:16607483 C19orf44;CALR3 0.58 6.9 0.39 3.75e-11 White blood cell count;Multiple sclerosis; CESC cis rs863345 0.604 rs60104403 chr1:158500847 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -7.0 -0.4 2.09e-11 Pneumococcal bacteremia; CESC trans rs4716602 0.633 rs10249382 chr7:156159349 G/T cg07175507 chr18:77160758 NFATC1 -0.44 -6.05 -0.35 4.95e-9 Anti-saccade response; CESC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg18876405 chr7:65276391 NA 0.45 6.15 0.35 2.78e-9 Aortic root size; CESC cis rs10504229 1.000 rs59275611 chr8:58195191 G/A cg22535103 chr8:58192502 C8orf71 -1.08 -13.04 -0.63 2.24e-30 Developmental language disorder (linguistic errors); CESC cis rs2708240 0.875 rs759177 chr7:147575230 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.23e-8 QT interval (drug interaction); CESC cis rs10794720 0.529 rs11250278 chr10:1173765 G/A cg08668510 chr10:1095578 IDI1 0.84 5.22 0.31 3.6e-7 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease; CESC cis rs7178909 0.902 rs3784386 chr15:90437426 A/G cg19708238 chr15:90437601 AP3S2 0.43 6.1 0.35 3.77e-9 Common traits (Other); CESC cis rs2486288 0.586 rs12909883 chr15:45572054 G/C cg21132104 chr15:45694354 SPATA5L1 -0.56 -6.7 -0.38 1.22e-10 Glomerular filtration rate; CESC cis rs3768617 0.510 rs3768621 chr1:183090057 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.44e-35 Fuchs's corneal dystrophy; CESC cis rs7089973 0.966 rs61867966 chr10:116584362 T/C cg23260525 chr10:116636907 FAM160B1 0.36 5.85 0.34 1.46e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg01579765 chr21:45077557 HSF2BP -0.54 -9.37 -0.5 3.36e-18 Mean corpuscular volume; CESC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg26314531 chr2:26401878 FAM59B -0.6 -6.8 -0.39 7.03e-11 Gut microbiome composition (summer); CESC cis rs3809566 1.000 rs4774471 chr15:63332645 A/T cg05507819 chr15:63340323 TPM1 -0.51 -6.31 -0.36 1.16e-9 Platelet count; CESC cis rs12477438 0.520 rs6542869 chr2:99783403 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.4 0.69 1.21e-38 Chronic sinus infection; CESC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg17294928 chr15:75287854 SCAMP5 0.49 6.48 0.37 4.34e-10 Breast cancer; CESC cis rs6987853 0.931 rs3099936 chr8:42384331 C/T cg09913449 chr8:42400586 C8orf40 -0.39 -6.01 -0.35 6.12e-9 Mean corpuscular hemoglobin concentration; CESC cis rs8180040 0.967 rs4858890 chr3:47405456 A/G cg27129171 chr3:47204927 SETD2 -0.65 -9.83 -0.52 1.18e-19 Colorectal cancer; CESC cis rs7662987 1.000 rs28730595 chr4:100003333 A/G cg13256891 chr4:100009986 ADH5 -0.72 -5.38 -0.31 1.62e-7 Smoking initiation; CESC cis rs7020830 0.830 rs308499 chr9:37348059 C/G cg14294708 chr9:37120828 ZCCHC7 1.1 18.82 0.76 9.37e-51 Schizophrenia; CESC cis rs10851478 0.872 rs12906134 chr15:49969620 G/T cg08060515 chr15:49448048 GALK2;COPS2 0.43 5.2 0.3 3.97e-7 Oral cavity cancer; CESC cis rs17001868 0.568 rs17001846 chr22:40744053 A/G cg07138101 chr22:40742427 ADSL 0.58 5.73 0.33 2.75e-8 Mammographic density (dense area); CESC cis rs6964587 0.773 rs62467797 chr7:91889722 G/A cg17063962 chr7:91808500 NA 0.56 7.01 0.4 1.97e-11 Breast cancer; CESC cis rs1395 0.778 rs62128747 chr2:27412605 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 5.85 0.34 1.44e-8 Blood metabolite levels; CESC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg09165964 chr15:75287851 SCAMP5 0.5 6.49 0.37 4.19e-10 Breast cancer; CESC cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg03433033 chr1:76189801 ACADM 0.6 5.87 0.34 1.27e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10097731 0.901 rs10464890 chr8:82042727 A/G cg25230327 chr8:82042993 NA -0.57 -6.37 -0.36 8.36e-10 Serum total protein level; CESC cis rs11676348 1.000 rs11676348 chr2:219010146 C/T cg00012203 chr2:219082015 ARPC2 -0.53 -6.86 -0.39 4.98e-11 Ulcerative colitis; CESC cis rs4689388 0.926 rs4688986 chr4:6285797 C/A cg25554036 chr4:6271136 WFS1 0.56 9.28 0.5 6.31e-18 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg00684032 chr4:1343700 KIAA1530 -0.37 -5.04 -0.3 8.62e-7 Obesity-related traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06506598 chr5:79783889 FAM151B -0.4 -6.03 -0.35 5.42e-9 Gambling; CESC cis rs9457247 1.000 rs239935 chr6:167411788 G/A cg23791538 chr6:167370224 RNASET2 -0.59 -8.47 -0.46 1.7e-15 Crohn's disease; CESC cis rs12079745 0.590 rs80215043 chr1:169193763 T/C cg09363564 chr1:169337483 NME7;BLZF1 -1.1 -6.51 -0.37 3.77e-10 QT interval; CESC cis rs3096299 0.933 rs747485 chr16:89474094 T/C cg02187348 chr16:89574699 SPG7 0.53 7.11 0.4 1.06e-11 Multiple myeloma (IgH translocation); CESC cis rs12541635 0.902 rs59123253 chr8:107006365 C/T cg10147462 chr8:107024639 NA 0.41 5.72 0.33 2.89e-8 Age of smoking initiation; CESC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1976403 0.510 rs1697421 chr1:21823292 C/T cg02390115 chr1:21767211 NBPF3 0.4 5.88 0.34 1.22e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs3733585 0.605 rs4697708 chr4:10121189 A/G cg11266682 chr4:10021025 SLC2A9 -0.56 -10.47 -0.54 1.08e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 7.0 0.4 2.04e-11 Bipolar disorder; CESC cis rs17092148 0.636 rs66535774 chr20:33448560 T/C cg24642439 chr20:33292090 TP53INP2 -0.51 -5.45 -0.32 1.16e-7 Neuroticism; CESC cis rs1152591 0.624 rs1266927 chr14:64651663 C/A cg23250157 chr14:64679961 SYNE2 0.44 6.54 0.37 3.15e-10 Atrial fibrillation; CESC cis rs9911578 0.839 rs1871751 chr17:57190368 A/G cg12560992 chr17:57184187 TRIM37 1.0 17.18 0.73 5.77e-45 Intelligence (multi-trait analysis); CESC cis rs1878931 0.582 rs40633 chr16:3425325 A/G cg02880119 chr16:3481970 NA 0.41 5.25 0.31 3.2e-7 Body mass index (adult); CESC cis rs6456156 0.692 rs9457270 chr6:167512928 A/G cg23791538 chr6:167370224 RNASET2 -0.52 -6.72 -0.38 1.09e-10 Primary biliary cholangitis; CESC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.47 6.05 0.35 4.83e-9 Tonsillectomy; CESC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg27170947 chr2:26402098 FAM59B 0.87 10.08 0.53 1.88e-20 Gut microbiome composition (summer); CESC cis rs858239 0.509 rs6975524 chr7:23186452 T/C cg23682824 chr7:23144976 KLHL7 0.5 6.56 0.37 2.77e-10 Cerebrospinal fluid biomarker levels; CESC cis rs8067545 0.611 rs7216599 chr17:20015600 G/C cg13482628 chr17:19912719 NA 0.4 5.31 0.31 2.28e-7 Schizophrenia; CESC cis rs4835473 0.932 rs4835305 chr4:144744799 G/A cg25736465 chr4:144833511 NA -0.35 -5.43 -0.32 1.28e-7 Immature fraction of reticulocytes; CESC cis rs6676180 0.555 rs871665 chr1:119772663 C/T cg05756136 chr1:119680316 WARS2 -0.39 -5.16 -0.3 4.82e-7 Monobrow; CESC cis rs5763662 1.000 rs5763681 chr22:30389846 A/G cg21388335 chr22:29999516 NF2 0.86 5.11 0.3 6.18e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs1816752 1.000 rs7326932 chr13:25004493 A/T cg02811702 chr13:24901961 NA 0.37 5.37 0.31 1.73e-7 Obesity-related traits; CESC cis rs7555523 0.887 rs4269750 chr1:165711510 C/T cg24409356 chr1:165738333 TMCO1 0.97 8.67 0.47 4.48e-16 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs2730245 1.000 rs2730241 chr7:158723014 T/C cg24397884 chr7:158709396 WDR60 -0.85 -12.59 -0.61 8.25e-29 Height; CESC cis rs11997175 0.546 rs10808337 chr8:33583850 T/C ch.8.33884649F chr8:33765107 NA 0.54 6.94 0.39 2.96e-11 Body mass index; CESC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.6 0.33 5.3e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg04234412 chr22:24373322 LOC391322 -0.5 -6.94 -0.39 2.98e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7923452 0.938 rs753173 chr10:30778738 T/C cg25182066 chr10:30743637 MAP3K8 0.47 5.26 0.31 2.93e-7 Itch intensity from mosquito bite; CESC cis rs941873 0.772 rs1316312 chr10:81110417 G/C cg08514558 chr10:81106712 PPIF 0.34 5.78 0.33 2.06e-8 Height; CESC trans rs634534 0.622 rs552130 chr11:65732800 T/C cg17712092 chr4:129076599 LARP1B 0.63 8.48 0.46 1.6e-15 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs1878931 0.501 rs9635563 chr16:3416940 A/G cg22508957 chr16:3507546 NAT15 -0.38 -5.54 -0.32 7.15e-8 Body mass index (adult); CESC cis rs6831352 1.000 rs1126671 chr4:100048414 T/C cg21548116 chr4:100009993 ADH5 0.48 5.15 0.3 4.98e-7 Alcohol dependence; CESC trans rs7726839 0.561 rs72703058 chr5:584519 G/A cg25482853 chr8:67687455 SGK3 0.88 9.24 0.49 8.24e-18 Obesity-related traits; CESC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.6 0.64 2.58e-32 Prudent dietary pattern; CESC cis rs644799 0.965 rs11021317 chr11:95517576 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.56 7.02 0.4 1.9e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9937943 0.512 rs13335886 chr16:74577161 C/G cg01733217 chr16:74700730 RFWD3 -0.63 -6.72 -0.38 1.09e-10 Neutrophil percentage of white cells; CESC cis rs3125734 0.633 rs1368157 chr10:64001114 T/C cg09941381 chr10:64027924 RTKN2 -0.32 -5.27 -0.31 2.89e-7 Rheumatoid arthritis; CESC cis rs68170813 0.521 rs75035695 chr7:106818731 T/C cg02696742 chr7:106810147 HBP1 -0.53 -5.07 -0.3 7.37e-7 Coronary artery disease; CESC cis rs826838 0.559 rs4882276 chr12:38611994 T/C cg26384229 chr12:38710491 ALG10B 0.46 6.56 0.37 2.76e-10 Heart rate; CESC cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg16144293 chr14:75469539 EIF2B2 0.4 5.12 0.3 5.93e-7 Height; CESC cis rs7617480 0.617 rs7610519 chr3:48746427 C/G cg07636037 chr3:49044803 WDR6 0.78 9.79 0.52 1.5700000000000001e-19 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs6424115 0.729 rs1737362 chr1:24054800 T/C cg10978503 chr1:24200527 CNR2 0.27 5.35 0.31 1.88e-7 Immature fraction of reticulocytes; CESC cis rs72945132 0.882 rs12099016 chr11:70195161 C/G cg00319359 chr11:70116639 PPFIA1 0.72 6.84 0.39 5.42e-11 Coronary artery disease; CESC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg24818145 chr4:99064322 C4orf37 0.39 5.06 0.3 7.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12477438 0.501 rs12995473 chr2:99764884 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.48 0.69 6.26e-39 Chronic sinus infection; CESC cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 5.98 0.34 7.09e-9 Colorectal cancer; CESC cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.91 7.9 0.44 7.25e-14 Initial pursuit acceleration; CESC cis rs3008870 0.755 rs2065002 chr1:67487119 A/C cg08660285 chr1:67390436 MIER1;WDR78 -0.62 -8.07 -0.44 2.42e-14 Lymphocyte percentage of white cells; CESC cis rs4972806 0.849 rs2071581 chr2:177026148 G/T cg14324370 chr2:177042789 NA 0.42 5.93 0.34 9.51e-9 IgG glycosylation; CESC cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg17366294 chr4:99064904 C4orf37 0.54 7.14 0.4 8.72e-12 Colonoscopy-negative controls vs population controls; CESC cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.97 9.71 0.51 2.96e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7714584 1.000 rs80075680 chr5:150223737 C/T cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs10883723 0.737 rs7074444 chr10:104249922 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.44 0.42 1.43e-12 Allergic disease (asthma, hay fever or eczema); CESC trans rs4843747 0.671 rs4075599 chr16:88107423 C/G cg26811252 chr16:29126840 RRN3P2 0.58 7.89 0.44 7.74e-14 Menopause (age at onset); CESC cis rs926938 0.560 rs360610 chr1:115393915 T/C cg12756093 chr1:115239321 AMPD1 0.46 6.21 0.36 2.03e-9 Autism; CESC cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg23711669 chr6:146136114 FBXO30 0.97 14.77 0.67 2.05e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg03060546 chr3:49711283 APEH 0.5 6.05 0.35 4.94e-9 Parkinson's disease; CESC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.51 -5.84 -0.34 1.48e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7131987 0.903 rs6487796 chr12:29422764 A/G cg09582351 chr12:29534625 ERGIC2 -0.36 -5.67 -0.33 3.8e-8 QT interval; CESC trans rs1728785 0.901 rs2862781 chr16:68639234 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 7.69 0.43 2.91e-13 Ulcerative colitis; CESC cis rs7191439 0.626 rs8059794 chr16:88787388 C/T cg27087555 chr16:88793112 FAM38A -1.28 -11.66 -0.58 1.26e-25 Plateletcrit; CESC cis rs3862030 0.500 rs11191327 chr10:104303883 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.49 0.42 1e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs155076 1.000 rs567166 chr13:21837519 T/C cg11317459 chr13:21872234 NA -1.01 -10.78 -0.55 1.07e-22 White matter hyperintensity burden; CESC cis rs2637266 0.630 rs2588330 chr10:78555185 A/C cg18941641 chr10:78392320 NA 0.4 7.57 0.42 6.04e-13 Pulmonary function; CESC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg07701084 chr6:150067640 NUP43 0.41 5.57 0.32 6.38e-8 Lung cancer; CESC cis rs12541635 0.677 rs7819501 chr8:107006962 C/T cg10147462 chr8:107024639 NA -0.42 -6.25 -0.36 1.61e-9 Age of smoking initiation; CESC trans rs9951602 0.512 rs12458828 chr18:76648522 C/T cg02800362 chr5:177631904 HNRNPAB -0.65 -8.44 -0.46 2.15e-15 Obesity-related traits; CESC cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg01741372 chr11:783889 NA -0.46 -6.58 -0.37 2.44e-10 Breast cancer; CESC trans rs941207 0.542 rs4277148 chr12:57180855 C/T cg26462586 chr2:11164677 NA 0.38 6.02 0.35 5.82e-9 Platelet count; CESC trans rs7615952 0.611 rs9681518 chr3:125615130 A/G cg07211511 chr3:129823064 LOC729375 -0.89 -8.26 -0.45 7.12e-15 Blood pressure (smoking interaction); CESC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 9.27 0.49 6.73e-18 Platelet count; CESC cis rs9300255 0.620 rs1716173 chr12:123660721 A/T cg00376283 chr12:123451042 ABCB9 0.71 8.71 0.47 3.27e-16 Neutrophil percentage of white cells; CESC trans rs5756813 0.833 rs5756819 chr22:38188195 A/C cg19894588 chr14:64061835 NA 0.66 8.84 0.48 1.34e-16 Optic cup area;Vertical cup-disc ratio; CESC cis rs10484885 0.824 rs72919954 chr6:90515665 T/A cg13799429 chr6:90582589 CASP8AP2 -0.76 -7.13 -0.4 9.38e-12 QRS interval (sulfonylurea treatment interaction); CESC cis rs4253772 0.575 rs74879643 chr22:46660014 T/C cg00784671 chr22:46762841 CELSR1 -0.54 -5.43 -0.32 1.29e-7 LDL cholesterol;Cholesterol, total; CESC cis rs11122272 0.735 rs2486727 chr1:231539245 A/G cg06096015 chr1:231504339 EGLN1 0.41 5.89 0.34 1.15e-8 Hemoglobin concentration; CESC cis rs7267979 0.966 rs2482923 chr20:25308981 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -16.02 -0.7 7.43e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg23985595 chr17:80112537 CCDC57 0.42 6.63 0.38 1.9e-10 Life satisfaction; CESC cis rs734999 0.588 rs4648653 chr1:2535895 C/T cg20673091 chr1:2541236 MMEL1 0.42 6.92 0.39 3.35e-11 Ulcerative colitis; CESC cis rs2742417 0.603 rs2064064 chr3:45759995 C/T cg04837898 chr3:45731254 SACM1L -0.47 -6.21 -0.36 2.08e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs977987 0.898 rs12918797 chr16:75493810 T/C cg03315344 chr16:75512273 CHST6 0.54 7.9 0.44 7.62e-14 Dupuytren's disease; CESC cis rs6500395 1.000 rs9924078 chr16:48557918 A/C cg04672837 chr16:48644449 N4BP1 -0.45 -5.14 -0.3 5.39e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs360071 0.528 rs360094 chr1:226064846 C/T cg17950169 chr1:226067900 TMEM63A -0.4 -6.17 -0.35 2.6e-9 Response to radiotherapy in prostate cancer (toxicity, rectal bleeding); CESC cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.87 14.04 0.65 7.75e-34 Hip circumference adjusted for BMI; CESC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.4 0.31 1.49e-7 Tonsillectomy; CESC cis rs7149337 0.752 rs8021773 chr14:51691528 C/T cg23942311 chr14:51606299 NA 0.52 8.97 0.48 5.58e-17 Cancer; CESC cis rs977987 0.527 rs62059844 chr16:75429737 T/C cg03315344 chr16:75512273 CHST6 0.4 5.71 0.33 3e-8 Dupuytren's disease; CESC cis rs72945132 0.882 rs2276001 chr11:70181560 T/C cg00319359 chr11:70116639 PPFIA1 0.74 7.15 0.4 8.42e-12 Coronary artery disease; CESC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.64 8.4 0.46 2.68e-15 Total body bone mineral density; CESC cis rs1008375 0.931 rs6449309 chr4:17573208 C/T cg16339924 chr4:17578868 LAP3 0.83 10.42 0.54 1.55e-21 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg04369109 chr6:150039330 LATS1 -0.38 -5.31 -0.31 2.28e-7 Lung cancer; CESC cis rs10788264 0.518 rs1028632 chr10:124044657 C/G cg09507567 chr10:124027408 NA 0.44 6.36 0.36 8.56e-10 Total body bone mineral density; CESC cis rs9815354 1.000 rs9864217 chr3:41762206 G/A cg03022575 chr3:42003672 ULK4 0.51 5.1 0.3 6.62e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs561341 0.660 rs7406043 chr17:30220152 C/G cg00745463 chr17:30367425 LRRC37B -0.62 -6.24 -0.36 1.68e-9 Hip circumference adjusted for BMI; CESC cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg08213375 chr14:104286397 PPP1R13B 0.33 5.48 0.32 9.74e-8 Reticulocyte count; CESC cis rs4409675 0.576 rs12070659 chr1:28227175 G/A cg23691781 chr1:28212827 C1orf38 0.28 5.62 0.33 4.73e-8 Corneal astigmatism; CESC cis rs1152591 0.729 rs1255988 chr14:64657684 C/A cg23250157 chr14:64679961 SYNE2 0.53 7.64 0.43 3.86e-13 Atrial fibrillation; CESC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs7917772 0.503 rs7068535 chr10:104349127 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.94e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs123509 0.874 rs339683 chr3:42788511 G/T cg12982090 chr3:42733453 KBTBD5 0.72 8.68 0.47 4.13e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg04414720 chr1:150670196 GOLPH3L 0.44 5.82 0.34 1.72e-8 Melanoma; CESC trans rs2693676 0.504 rs944120 chr14:99603389 A/T cg17465227 chr4:47427752 GABRB1 0.61 6.49 0.37 4.17e-10 Corneal curvature; CESC cis rs2204008 0.748 rs8186658 chr12:38301461 A/C cg13010199 chr12:38710504 ALG10B 0.4 5.14 0.3 5.25e-7 Bladder cancer; CESC cis rs778371 1.000 rs778370 chr2:233743363 C/T cg08000102 chr2:233561755 GIGYF2 -0.82 -13.18 -0.63 7.3e-31 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03899909 chr5:179159660 MAML1 0.58 6.66 0.38 1.54e-10 Gut microbiome composition (summer); CESC cis rs7089973 0.932 rs17794346 chr10:116643095 C/T cg23260525 chr10:116636907 FAM160B1 -0.34 -5.41 -0.32 1.42e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg01988459 chr11:68622903 NA -0.39 -5.21 -0.3 3.76e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4332037 0.539 rs4719416 chr7:2106608 G/A cg23422044 chr7:1970798 MAD1L1 -0.45 -5.35 -0.31 1.89e-7 Bipolar disorder; CESC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg19592336 chr6:28129416 ZNF389 -0.62 -8.32 -0.46 4.66e-15 Depression; CESC cis rs9902453 0.845 rs3102556 chr17:28042542 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.53 0.46 1.15e-15 Coffee consumption (cups per day); CESC cis rs1865721 0.771 rs7231277 chr18:73136724 A/G cg26385618 chr18:73139727 C18orf62 -0.51 -8.36 -0.46 3.47e-15 Intelligence; CESC cis rs796364 0.813 rs4672686 chr2:201065044 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.58 5.59 0.32 5.73e-8 Schizophrenia; CESC trans rs1116547 0.602 rs6896501 chr5:112906601 C/T cg10115368 chr14:100435663 NA 0.51 6.04 0.35 5.06e-9 Cerebral amyloid angiopathy; CESC cis rs9811920 0.609 rs4244711 chr3:99657205 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.64 -10.16 -0.53 1.09e-20 Axial length; CESC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg23978390 chr7:1156363 C7orf50 0.48 5.73 0.33 2.66e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg04166393 chr7:2884313 GNA12 0.59 7.77 0.43 1.79e-13 Height; CESC cis rs2012796 1.000 rs7153469 chr14:81820979 T/G cg02996355 chr14:81879375 NA 0.57 6.82 0.39 6.15e-11 Night sleep phenotypes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12767885 chr10:134350658 INPP5A -0.45 -6.06 -0.35 4.75e-9 Fibrinogen levels; CESC cis rs6088590 1.000 rs6120705 chr20:33313740 T/C cg24642439 chr20:33292090 TP53INP2 0.84 11.78 0.59 4.81e-26 Coronary artery disease; CESC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg00784671 chr22:46762841 CELSR1 0.39 5.24 0.31 3.33e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6088580 0.634 rs6059878 chr20:33087166 A/T cg06115741 chr20:33292138 TP53INP2 0.45 5.8 0.34 1.88e-8 Glomerular filtration rate (creatinine); CESC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.17 0.57 5.32e-24 Alzheimer's disease; CESC cis rs10751667 1.000 rs10902246 chr11:953674 T/C cg06064525 chr11:970664 AP2A2 -0.39 -7.01 -0.4 1.96e-11 Alzheimer's disease (late onset); CESC cis rs6540559 0.546 rs75308488 chr1:210030639 T/C cg23283495 chr1:209979779 IRF6 0.49 5.07 0.3 7.43e-7 Cleft lip with or without cleft palate; CESC cis rs17826219 0.706 rs55764512 chr17:29085758 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Body mass index; CESC cis rs1371867 0.846 rs2047249 chr8:101234126 A/G cg11906718 chr8:101322791 RNF19A -0.56 -6.8 -0.39 7.02e-11 Atrioventricular conduction; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13984512 chr1:145438431 TXNIP -0.4 -6.38 -0.36 8.03e-10 Gambling; CESC cis rs2637266 0.729 rs846618 chr10:78545455 G/A cg18941641 chr10:78392320 NA 0.41 7.6 0.42 5.05e-13 Pulmonary function; CESC cis rs2531992 1.000 rs710893 chr16:4014964 A/G cg05927578 chr16:4029543 ADCY9 0.44 5.55 0.32 6.83e-8 Waist circumference; CESC cis rs11864453 0.679 rs2303285 chr16:72124495 A/C cg16558253 chr16:72132732 DHX38 -0.55 -8.54 -0.46 1.08e-15 Fibrinogen levels; CESC cis rs9911578 0.967 rs11656413 chr17:57082013 A/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.24 -0.31 3.21e-7 Intelligence (multi-trait analysis); CESC cis rs826838 0.967 rs2069211 chr12:39128892 C/T cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg17224732 chr1:78148372 ZZZ3 -0.41 -6.14 -0.35 3.02e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs61931739 0.534 rs10844801 chr12:34230940 A/T cg26384229 chr12:38710491 ALG10B 0.64 9.4 0.5 2.7e-18 Morning vs. evening chronotype; CESC cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg07636037 chr3:49044803 WDR6 1.03 18.76 0.76 1.49e-50 Parkinson's disease; CESC cis rs2274273 1.000 rs7160110 chr14:55594635 A/G cg04306507 chr14:55594613 LGALS3 0.3 5.87 0.34 1.29e-8 Protein biomarker; CESC trans rs3780486 0.846 rs7873903 chr9:33142728 G/A cg20290983 chr6:43655470 MRPS18A 0.97 17.15 0.73 7.49e-45 IgG glycosylation; CESC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg14159672 chr1:205819179 PM20D1 -0.41 -5.52 -0.32 7.93e-8 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg10553204 chr2:20871195 GDF7 -0.37 -5.18 -0.3 4.4e-7 Abdominal aortic aneurysm; CESC cis rs2108622 0.711 rs113343664 chr19:15978993 G/C cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs1483890 0.723 rs12629224 chr3:69411188 T/C cg22125112 chr3:69402811 FRMD4B 0.39 5.17 0.3 4.67e-7 Resting heart rate; CESC cis rs763121 0.853 rs1065201 chr22:39069510 T/C cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs208520 0.874 rs208481 chr6:66922636 A/G cg07460842 chr6:66804631 NA -0.86 -10.49 -0.54 9.23e-22 Exhaled nitric oxide output; CESC cis rs11711311 1.000 rs2242108 chr3:113433903 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.71 10.31 0.54 3.46e-21 IgG glycosylation; CESC cis rs17376456 0.569 rs7713956 chr5:93133185 T/C cg21475434 chr5:93447410 FAM172A -0.5 -5.11 -0.3 6.26e-7 Diabetic retinopathy; CESC cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.46 0.32 1.1e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.83 -9.25 -0.49 7.55e-18 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg12463550 chr7:65579703 CRCP -0.53 -6.84 -0.39 5.56e-11 Aortic root size; CESC cis rs2797160 1.000 rs6933471 chr6:126017029 T/G cg05901451 chr6:126070800 HEY2 0.46 6.63 0.38 1.86e-10 Endometrial cancer; CESC cis rs4834770 1.000 rs4336213 chr4:120236469 G/T cg09307838 chr4:120376055 NA 0.46 5.81 0.34 1.76e-8 Blood protein levels; CESC cis rs4253772 0.745 rs9626823 chr22:46645148 G/A cg00784671 chr22:46762841 CELSR1 -0.52 -5.42 -0.32 1.35e-7 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07499546 chr1:40839445 SMAP2 0.58 6.49 0.37 4.19e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09326880 chr3:43147587 C3orf39 0.55 6.78 0.38 7.9e-11 Gut microbiome composition (summer); CESC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg24531977 chr5:56204891 C5orf35 -0.48 -6.01 -0.35 6.1e-9 Coronary artery disease; CESC cis rs6714710 0.603 rs34502870 chr2:98405929 A/G cg26665480 chr2:98280029 ACTR1B 0.57 8.03 0.44 3.3e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs9297145 1.000 rs10953280 chr7:98763405 A/G cg05967295 chr7:98741636 SMURF1 -0.99 -13.09 -0.63 1.6e-30 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs7605827 0.930 rs1997304 chr2:15512073 G/T cg19274914 chr2:15703543 NA 0.32 5.58 0.32 5.95e-8 Educational attainment (years of education); CESC cis rs5769765 0.954 rs6009900 chr22:50236610 T/C cg26441486 chr22:50317300 CRELD2 0.4 5.41 0.32 1.43e-7 Schizophrenia; CESC cis rs7605827 0.930 rs1986279 chr2:15617390 G/A cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs2066819 1.000 rs116535779 chr12:56739261 A/G cg26316697 chr12:56727976 PAN2 0.72 6.9 0.39 3.81e-11 Psoriasis vulgaris; CESC cis rs6964587 0.626 rs4729014 chr7:91550707 A/G cg17063962 chr7:91808500 NA -0.45 -6.29 -0.36 1.29e-9 Breast cancer; CESC cis rs60154123 0.772 rs628908 chr1:210428002 C/T cg21951975 chr1:209979733 IRF6 0.44 5.69 0.33 3.3e-8 Coronary artery disease; CESC cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11264213 0.901 rs72661631 chr1:36417453 A/G cg27506609 chr1:36549197 TEKT2 0.67 5.54 0.32 7.16e-8 Schizophrenia; CESC cis rs34375054 0.525 rs7133006 chr12:125606123 G/A cg25124228 chr12:125621409 AACS -0.54 -6.78 -0.38 7.85e-11 Post bronchodilator FEV1/FVC ratio; CESC cis rs6032067 0.777 rs34855539 chr20:43799036 T/G cg11264863 chr20:43835661 SEMG1 0.5 5.39 0.31 1.55e-7 Blood protein levels; CESC cis rs763121 0.776 rs4820346 chr22:39125074 C/G cg06544989 chr22:39130855 UNC84B -0.46 -7.76 -0.43 1.88e-13 Menopause (age at onset); CESC cis rs8050907 0.590 rs2270364 chr16:4526750 G/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 5.72 0.33 2.93e-8 Obesity-related traits; CESC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.56 0.37 2.79e-10 Bipolar disorder; CESC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg11644478 chr21:40555479 PSMG1 -0.52 -6.92 -0.39 3.34e-11 Menarche (age at onset); CESC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg10053473 chr17:62856997 LRRC37A3 -0.7 -7.4 -0.41 1.78e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2625529 0.652 rs2957736 chr15:72265344 A/G cg16672083 chr15:72433130 SENP8 0.46 6.78 0.38 7.68e-11 Red blood cell count; CESC cis rs826838 0.967 rs7963716 chr12:38876090 C/T cg26384229 chr12:38710491 ALG10B 0.82 13.81 0.65 4.71e-33 Heart rate; CESC cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg16339924 chr4:17578868 LAP3 0.74 9.68 0.51 3.59e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg00290607 chr11:67383545 NA 0.39 5.56 0.32 6.72e-8 Mean corpuscular volume; CESC cis rs4555082 0.874 rs2816606 chr14:105716034 C/T cg27165867 chr14:105738592 BRF1 -0.48 -5.23 -0.31 3.48e-7 Mean platelet volume;Platelet distribution width; CESC cis rs34779708 0.931 rs9663401 chr10:35278849 G/T cg03585969 chr10:35415529 CREM 0.77 10.16 0.53 1.05e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs6828577 0.862 rs298994 chr4:119627253 A/G cg05098011 chr1:151736092 OAZ3;MRPL9 0.48 6.13 0.35 3.21e-9 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs193541 0.564 rs407230 chr5:122345727 G/A cg19412675 chr5:122181750 SNX24 -0.45 -5.29 -0.31 2.57e-7 Glucose homeostasis traits; CESC cis rs7680126 0.596 rs35782983 chr4:10117728 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -6.34 -0.36 9.71e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs911555 0.723 rs6575986 chr14:103886671 G/A cg09975044 chr14:104007538 NA 0.45 5.62 0.33 4.78e-8 Intelligence (multi-trait analysis); CESC cis rs533581 0.866 rs502258 chr16:88968547 G/A cg16701003 chr16:89028210 CBFA2T3 0.47 6.43 0.37 5.96e-10 Social autistic-like traits; CESC cis rs6032067 0.641 rs74174934 chr20:43761331 T/G cg10761708 chr20:43804764 PI3 0.47 5.08 0.3 7.16e-7 Blood protein levels; CESC trans rs11098499 1.000 rs1011054 chr4:120202387 A/G cg25214090 chr10:38739885 LOC399744 -0.63 -8.4 -0.46 2.66e-15 Corneal astigmatism; CESC cis rs12477438 0.798 rs6732579 chr2:99560239 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.73 -10.16 -0.53 1.04e-20 Chronic sinus infection; CESC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.88 0.39 4.22e-11 Bipolar disorder; CESC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.95 14.0 0.65 1.01e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg21573476 chr21:45109991 RRP1B -0.49 -6.87 -0.39 4.55e-11 Mean corpuscular volume; CESC cis rs7267979 0.714 rs6132825 chr20:25238309 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.69 10.58 0.54 4.75e-22 Liver enzyme levels (alkaline phosphatase); CESC cis rs9309473 0.500 rs11688718 chr2:73760939 C/T cg20560298 chr2:73613845 ALMS1 -0.51 -7.31 -0.41 3.07e-12 Metabolite levels; CESC cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg17294928 chr15:75287854 SCAMP5 -0.51 -5.69 -0.33 3.43e-8 Blood trace element (Zn levels); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03965764 chr11:45248109 NA 0.46 6.46 0.37 4.86e-10 Fibrinogen levels; CESC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg10074409 chr1:209979377 IRF6 0.39 5.19 0.3 4.24e-7 Cleft lip with or without cleft palate; CESC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg18402987 chr7:1209562 NA 0.76 7.61 0.42 4.74e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9595066 0.627 rs4941486 chr13:44749157 G/A cg04068111 chr13:44716778 NA -0.47 -6.25 -0.36 1.63e-9 Schizophrenia; CESC cis rs7312933 0.558 rs4768411 chr12:42855390 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.47 -6.27 -0.36 1.42e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7927771 0.832 rs935914 chr11:47387599 C/T cg18512352 chr11:47633146 NA 0.49 7.0 0.4 2.05e-11 Subjective well-being; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02404575 chr19:53237871 ZNF611 0.47 6.51 0.37 3.7e-10 Asthma; CESC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg02980000 chr4:1222292 CTBP1 0.42 5.15 0.3 5.06e-7 Longevity; CESC cis rs6456156 0.792 rs4710178 chr6:167513532 G/A cg23791538 chr6:167370224 RNASET2 -0.4 -5.21 -0.3 3.88e-7 Primary biliary cholangitis; CESC cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.716 rs2712071 chr2:23990419 A/G cg08917208 chr2:24149416 ATAD2B 0.59 5.76 0.33 2.3e-8 Lymphocyte counts; CESC cis rs9660180 0.839 rs12040826 chr1:1705287 A/C cg17747265 chr1:1875780 NA -0.56 -8.86 -0.48 1.23e-16 Body mass index; CESC cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6831352 0.801 rs2602897 chr4:100046293 A/T cg13256891 chr4:100009986 ADH5 0.77 8.43 0.46 2.27e-15 Alcohol dependence; CESC cis rs1878931 0.531 rs9635548 chr16:3417156 G/A cg22508957 chr16:3507546 NAT15 -0.38 -5.54 -0.32 7.15e-8 Body mass index (adult); CESC cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg05535760 chr7:792225 HEATR2 -0.82 -8.48 -0.46 1.62e-15 Cerebrospinal P-tau181p levels; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg14313238 chr10:92632228 RPP30 0.44 6.25 0.36 1.61e-9 Positive affect; CESC cis rs7772486 0.566 rs735536 chr6:146036832 A/C cg23711669 chr6:146136114 FBXO30 -0.89 -13.19 -0.63 6.74e-31 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21185233 chr4:147442789 SLC10A7 -0.57 -6.96 -0.39 2.63e-11 Gut microbiome composition (summer); CESC cis rs10208940 0.764 rs7583649 chr2:68830939 T/C cg12452813 chr2:68675892 NA 0.52 5.18 0.3 4.47e-7 Urate levels in lean individuals; CESC cis rs2742234 0.541 rs1254958 chr10:43702143 C/T cg15436174 chr10:43711423 RASGEF1A 0.5 5.85 0.34 1.45e-8 Hirschsprung disease; CESC cis rs71277158 0.688 rs12488988 chr3:169879860 T/C cg04067573 chr3:169899625 PHC3 0.71 7.04 0.4 1.62e-11 Prostate cancer; CESC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg10295955 chr4:187884368 NA -1.08 -23.01 -0.82 4.07e-65 Lobe attachment (rater-scored or self-reported); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00609645 chr6:26205074 HIST1H4E -0.53 -6.28 -0.36 1.36e-9 Ulcerative colitis; CESC cis rs6582630 0.519 rs7305570 chr12:38349285 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.95 0.56 2.81e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs9300255 0.569 rs1716170 chr12:123716513 C/T cg05973401 chr12:123451056 ABCB9 0.51 5.66 0.33 3.91e-8 Neutrophil percentage of white cells; CESC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg27121462 chr16:89883253 FANCA -0.49 -5.74 -0.33 2.61e-8 Vitiligo; CESC cis rs10504229 0.679 rs16921688 chr8:58054659 T/C cg22535103 chr8:58192502 C8orf71 -0.77 -8.08 -0.44 2.33e-14 Developmental language disorder (linguistic errors); CESC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg24549020 chr5:56110836 MAP3K1 0.47 5.81 0.34 1.78e-8 Initial pursuit acceleration; CESC cis rs2204008 0.837 rs4312131 chr12:38181087 G/T cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs7772486 0.790 rs9386141 chr6:146268623 T/A cg05347473 chr6:146136440 FBXO30 -0.52 -6.88 -0.39 4.23e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2952156 0.959 rs1565922 chr17:37831035 A/G cg20243544 chr17:37824526 PNMT 0.6 7.57 0.42 6.06e-13 Asthma; CESC cis rs793571 0.650 rs12899638 chr15:58920275 G/A cg05156742 chr15:59063176 FAM63B 0.76 10.71 0.55 1.8e-22 Schizophrenia; CESC cis rs782590 0.837 rs782585 chr2:55922930 C/T cg18811423 chr2:55921094 PNPT1 0.82 13.59 0.64 2.72e-32 Metabolic syndrome; CESC cis rs9486715 1.000 rs6902835 chr6:97063005 C/G cg18709589 chr6:96969512 KIAA0776 -0.42 -5.88 -0.34 1.23e-8 Headache; CESC cis rs7726839 1.000 rs7726839 chr5:618586 A/G cg09021430 chr5:549028 NA -0.44 -7.13 -0.4 9.83e-12 Obesity-related traits; CESC cis rs8114671 0.805 rs6060168 chr20:33621017 C/T cg06115741 chr20:33292138 TP53INP2 0.43 5.31 0.31 2.37e-7 Height; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg10893370 chr17:30228961 UTP6 -0.46 -6.14 -0.35 3.01e-9 Height; CESC cis rs55794721 0.509 rs12027135 chr1:25775733 A/T cg27572855 chr1:25598939 RHD 0.46 7.69 0.43 2.87e-13 Plateletcrit;Mean corpuscular volume; CESC cis rs9811920 0.928 rs2130369 chr3:99873317 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.4 6.5 0.37 3.89e-10 Axial length; CESC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg09658497 chr7:2847517 GNA12 -0.45 -6.53 -0.37 3.42e-10 Height; CESC cis rs8020095 0.571 rs7156655 chr14:67356061 T/C cg19548862 chr14:67692701 FAM71D -0.48 -5.82 -0.34 1.73e-8 Depression (quantitative trait); CESC cis rs8028182 0.636 rs4243034 chr15:75750969 G/A cg20655648 chr15:75932815 IMP3 0.51 6.5 0.37 4.07e-10 Sudden cardiac arrest; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00286214 chr16:2771425 PRSS27 0.52 6.31 0.36 1.17e-9 Gut microbiome composition (summer); CESC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg10295955 chr4:187884368 NA -1.08 -23.01 -0.82 4.07e-65 Lobe attachment (rater-scored or self-reported); CESC cis rs9303401 0.659 rs7210432 chr17:56668170 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.93 0.62 5.59e-30 Cognitive test performance; CESC cis rs61931739 0.500 rs11053277 chr12:34553835 T/A cg06521331 chr12:34319734 NA -0.36 -5.03 -0.3 9.01e-7 Morning vs. evening chronotype; CESC cis rs1729951 0.546 rs361246 chr3:136695667 G/A cg25687071 chr3:136751404 NA 0.4 5.35 0.31 1.86e-7 Neuroticism; CESC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg12756686 chr19:29218302 NA 0.49 6.8 0.39 6.72e-11 Methadone dose in opioid dependence; CESC cis rs863345 0.604 rs12123305 chr1:158498955 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs910316 0.967 rs7146523 chr14:75659880 T/C cg08847533 chr14:75593920 NEK9 -0.92 -16.11 -0.7 3.53e-41 Height; CESC trans rs2832077 0.527 rs1048546 chr21:30244877 G/T cg14791747 chr16:20752902 THUMPD1 0.47 6.38 0.36 7.72e-10 Cognitive test performance; CESC cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg12386194 chr3:101231763 SENP7 0.44 5.48 0.32 9.88e-8 Colorectal cancer; CESC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 10.85 0.55 6.37e-23 Platelet count; CESC cis rs3892630 0.878 rs1559177 chr19:33210646 A/G cg22980127 chr19:33182716 NUDT19 1.06 11.38 0.57 1.04e-24 Red blood cell traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14853922 chr1:179051253 TOR3A 0.6 6.99 0.39 2.24e-11 Gut microbiome composition (summer); CESC cis rs6430585 0.640 rs58301703 chr2:136532225 G/A cg07169764 chr2:136633963 MCM6 1.26 16.81 0.72 1.21e-43 Corneal structure; CESC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.4 0.37 7.06e-10 Electroencephalogram traits; CESC cis rs12368653 0.591 rs1552842 chr12:58012163 A/G cg00700412 chr12:58011837 NA -0.47 -7.34 -0.41 2.55e-12 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09148494 chr19:55866345 COX6B2;FAM71E2 -0.63 -7.74 -0.43 2.06e-13 Gut microbiome composition (summer); CESC cis rs7872515 0.887 rs10992234 chr9:94877836 A/G cg01248375 chr9:94877805 SPTLC1 0.56 6.11 0.35 3.63e-9 Bipolar disorder and schizophrenia; CESC cis rs3126085 0.935 rs4421596 chr1:152181673 G/A cg03465714 chr1:152285911 FLG -0.43 -5.16 -0.3 4.81e-7 Atopic dermatitis; CESC cis rs10924309 0.640 rs6700599 chr1:245854047 G/T cg00036263 chr1:245852353 KIF26B -0.53 -6.9 -0.39 3.82e-11 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs9584850 0.874 rs4584 chr13:99101869 G/C cg20750642 chr13:99100586 FARP1 -0.37 -5.55 -0.32 6.95e-8 Neuroticism; CESC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14996805 chr17:56430170 SUPT4H1 -0.51 -6.08 -0.35 4.28e-9 Gut microbiome composition (summer); CESC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg05754148 chr16:3507555 NAT15 0.67 6.51 0.37 3.68e-10 Tuberculosis; CESC trans rs1814175 0.527 rs7110797 chr11:49644096 T/C cg03929089 chr4:120376271 NA -0.75 -8.45 -0.46 1.96e-15 Height; CESC cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg24308560 chr3:49941425 MST1R 0.64 9.54 0.51 9.91e-19 Intelligence (multi-trait analysis); CESC cis rs1878931 0.615 rs4786412 chr16:3440390 C/T cg21433313 chr16:3507492 NAT15 -0.36 -5.31 -0.31 2.29e-7 Body mass index (adult); CESC cis rs959260 1.000 rs8081927 chr17:73379085 C/T cg12999837 chr17:73267436 MIF4GD -0.51 -5.85 -0.34 1.48e-8 Systemic lupus erythematosus; CESC trans rs1908814 0.516 rs13281077 chr8:11794814 C/T cg15556689 chr8:8085844 FLJ10661 0.53 6.56 0.37 2.75e-10 Neuroticism; CESC cis rs7923452 0.938 rs67812762 chr10:30759479 G/T cg18806716 chr10:30721971 MAP3K8 0.51 6.11 0.35 3.49e-9 Itch intensity from mosquito bite; CESC cis rs10465746 0.935 rs12758441 chr1:84352034 A/G cg10977910 chr1:84465055 TTLL7 0.48 6.52 0.37 3.63e-10 Obesity-related traits; CESC cis rs644799 1.000 rs500054 chr11:95593806 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.67 8.17 0.45 1.31e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7772486 0.597 rs9285508 chr6:146262697 G/T cg05347473 chr6:146136440 FBXO30 -0.64 -6.93 -0.39 3.24e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.13 0.53 1.35e-20 Prudent dietary pattern; CESC cis rs12474201 0.963 rs11676737 chr2:46929873 T/C cg06386533 chr2:46925753 SOCS5 0.91 12.61 0.61 7.02e-29 Height; CESC cis rs3741798 1.000 rs2160588 chr12:12487447 C/T cg08615371 chr12:12503544 MANSC1 0.79 6.1 0.35 3.64e-9 Cerebrospinal fluid biomarker levels; CESC cis rs7503807 0.967 rs12940622 chr17:78615571 G/A cg09596252 chr17:78655493 RPTOR 0.51 7.5 0.42 9.7e-13 Obesity; CESC cis rs4803468 0.967 rs3745290 chr19:41890003 C/T cg09537434 chr19:41945824 ATP5SL -1.01 -17.8 -0.74 3.63e-47 Height; CESC cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg15556689 chr8:8085844 FLJ10661 0.54 6.79 0.38 7.54e-11 Parkinson's disease; CESC cis rs826838 0.904 rs7973992 chr12:39168233 T/C cg26384229 chr12:38710491 ALG10B 0.78 13.28 0.63 3.36e-31 Heart rate; CESC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg02935154 chr7:12443704 VWDE 0.56 7.14 0.4 8.79e-12 Coronary artery disease; CESC cis rs9314323 0.693 rs13264882 chr8:26224240 G/T cg11498726 chr8:26250323 BNIP3L -0.45 -6.48 -0.37 4.37e-10 Red cell distribution width; CESC cis rs9911578 0.692 rs412000 chr17:56709058 G/C cg12560992 chr17:57184187 TRIM37 0.83 12.95 0.62 4.96e-30 Intelligence (multi-trait analysis); CESC cis rs10754283 0.967 rs1317864 chr1:90105448 A/G cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg19077165 chr18:44547161 KATNAL2 0.57 8.4 0.46 2.66e-15 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19182353 chr11:118479428 PHLDB1 -0.52 -6.16 -0.35 2.72e-9 Gut microbiome composition (summer); CESC cis rs2996428 0.601 rs10909804 chr1:3770929 A/G cg13057898 chr1:3703894 LRRC47 -0.46 -6.32 -0.36 1.09e-9 Red cell distribution width; CESC cis rs17253792 0.822 rs77990307 chr14:56070049 T/C cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs2228479 0.850 rs79244293 chr16:89896220 T/C cg06558623 chr16:89946397 TCF25 1.06 7.64 0.42 4.04e-13 Skin colour saturation; CESC cis rs807669 0.742 rs1206544 chr22:19215039 C/T cg02655711 chr22:19163373 SLC25A1 0.54 7.95 0.44 5.46e-14 Metabolite levels; CESC cis rs854765 0.583 rs12452254 chr17:17829434 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.23 0.36 1.86e-9 Total body bone mineral density; CESC cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg16339924 chr4:17578868 LAP3 0.57 7.1 0.4 1.15e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg10691866 chr7:65817282 TPST1 0.33 5.47 0.32 1.02e-7 Aortic root size; CESC cis rs644799 1.000 rs544119 chr11:95538624 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12661088 chr5:43120934 ZNF131 -0.42 -6.01 -0.35 6.07e-9 Gambling; CESC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg22907277 chr7:1156413 C7orf50 0.47 5.3 0.31 2.48e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg11764359 chr7:65958608 NA -0.92 -14.57 -0.67 9.81e-36 Aortic root size; CESC cis rs8114671 0.562 rs7266550 chr20:33495510 C/T cg06115741 chr20:33292138 TP53INP2 0.48 5.79 0.34 1.97e-8 Height; CESC trans rs10506458 1.000 rs17763435 chr12:63416511 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.27 17.05 0.72 1.67e-44 Hemostatic factors and hematological phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02176961 chr10:15130767 ACBD7 0.69 7.62 0.42 4.38e-13 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26824326 chr1:9664366 TMEM201 0.51 6.65 0.38 1.64e-10 Fibrinogen levels; CESC cis rs6499255 0.857 rs16959035 chr16:69707645 C/A cg15192750 chr16:69999425 NA 0.46 5.34 0.31 2.04e-7 IgE levels; CESC cis rs4803468 0.967 rs67047091 chr19:41938684 C/T cg09537434 chr19:41945824 ATP5SL 1.13 21.6 0.8 2.18e-60 Height; CESC cis rs6963495 0.818 rs73190133 chr7:105147821 G/C cg13798780 chr7:105162888 PUS7 0.76 7.8 0.43 1.47e-13 Bipolar disorder (body mass index interaction); CESC cis rs601339 0.938 rs1696344 chr12:123183059 C/T cg11919336 chr12:123188078 GPR109A 0.47 6.29 0.36 1.28e-9 Adiponectin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17199681 chr17:3540328 CTNS;SHPK 0.54 6.25 0.36 1.65e-9 Gut microbiome composition (summer); CESC cis rs9291683 0.588 rs17247314 chr4:10004743 C/G cg00071950 chr4:10020882 SLC2A9 0.84 15.4 0.69 1.2e-38 Bone mineral density; CESC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg12311346 chr5:56204834 C5orf35 -0.74 -8.72 -0.47 3.21e-16 Initial pursuit acceleration; CESC cis rs7827545 1.000 rs7463007 chr8:135567143 C/T cg17885191 chr8:135476712 NA 0.48 6.36 0.36 8.74e-10 Hypertension (SNP x SNP interaction); CESC cis rs7223966 1.000 rs6504173 chr17:61735056 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.55 0.42 7e-13 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg23048001 chr7:2026167 MAD1L1 0.48 6.2 0.36 2.12e-9 Bipolar disorder and schizophrenia; CESC cis rs35110281 0.600 rs914198 chr21:45117456 A/C cg21573476 chr21:45109991 RRP1B -0.55 -7.91 -0.44 6.87e-14 Mean corpuscular volume; CESC cis rs7116495 0.609 rs4387373 chr11:71774908 A/G cg18441811 chr11:71824068 C11orf51 -0.82 -5.14 -0.3 5.31e-7 Severe influenza A (H1N1) infection; CESC cis rs2274273 0.837 rs10141483 chr14:55786871 T/C cg04306507 chr14:55594613 LGALS3 0.31 6.07 0.35 4.34e-9 Protein biomarker; CESC trans rs11098499 0.954 rs10017543 chr4:120321420 G/A cg25214090 chr10:38739885 LOC399744 0.72 10.03 0.52 2.88e-20 Corneal astigmatism; CESC cis rs3780486 0.505 rs10758194 chr9:33157419 G/T cg13443165 chr9:33130375 B4GALT1 0.47 7.23 0.41 5.15e-12 IgG glycosylation; CESC cis rs763121 0.853 rs138713 chr22:39142615 T/C cg06544989 chr22:39130855 UNC84B 0.48 8.9 0.48 8.98e-17 Menopause (age at onset); CESC cis rs3820068 0.581 rs72645888 chr1:15929922 C/A cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs2952156 0.959 rs1495101 chr17:37832103 C/A cg07936489 chr17:37558343 FBXL20 -0.55 -6.65 -0.38 1.68e-10 Asthma; CESC cis rs258892 0.895 rs35317818 chr5:72073502 G/C cg21869765 chr5:72125136 TNPO1 -0.44 -5.52 -0.32 8.21e-8 Small cell lung carcinoma; CESC trans rs6084875 0.641 rs4815733 chr20:4722400 A/T cg10192164 chr16:30419175 ZNF771 -0.51 -6.15 -0.35 2.79e-9 Systemic lupus erythematosus; CESC cis rs35955747 0.840 rs9621221 chr22:31616169 G/A cg25791279 chr22:32026902 PISD -0.48 -5.77 -0.33 2.2e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs748404 0.631 rs6493084 chr15:43647627 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.64 0.43 3.88e-13 Lung cancer; CESC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.48 -0.32 1.01e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23956071 chr17:4710044 PLD2 0.62 7.43 0.42 1.54e-12 Gut microbiome composition (summer); CESC cis rs3820068 0.656 rs72645829 chr1:15889748 A/G cg18192808 chr1:15853278 DNAJC16 0.43 5.17 0.3 4.6e-7 Systolic blood pressure; CESC cis rs7590720 0.840 rs705648 chr2:216933792 C/T cg12620499 chr2:216877984 MREG 0.8 10.1 0.53 1.7e-20 Alcohol dependence; CESC cis rs6484504 0.600 rs366758 chr11:31222499 A/C cg14844989 chr11:31128820 NA -0.42 -5.96 -0.34 7.83e-9 Red blood cell count; CESC cis rs7267979 0.714 rs6115107 chr20:25237390 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.71 11.37 0.57 1.18e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs1348850 0.526 rs1345138 chr2:178387100 A/T cg22681709 chr2:178499509 PDE11A -0.5 -5.16 -0.3 4.97e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg04944784 chr2:26401820 FAM59B -0.66 -7.4 -0.41 1.82e-12 Gut microbiome composition (summer); CESC cis rs709400 0.894 rs10143293 chr14:104063014 G/A cg12935359 chr14:103987150 CKB -0.47 -6.18 -0.35 2.46e-9 Body mass index; CESC trans rs6700559 0.810 rs2808250 chr1:200592547 A/T cg05185519 chr16:2972941 FLYWCH1 -0.48 -6.28 -0.36 1.4e-9 Coronary artery disease; CESC cis rs2933343 0.649 rs789216 chr3:128594503 A/C cg11901034 chr3:128598214 ACAD9 -0.37 -5.43 -0.32 1.31e-7 IgG glycosylation; CESC cis rs6502050 0.740 rs4789748 chr17:80093061 A/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.59 -0.38 2.37e-10 Life satisfaction; CESC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg04414720 chr1:150670196 GOLPH3L 0.54 7.03 0.4 1.7e-11 Melanoma; CESC cis rs1395 0.744 rs3739092 chr2:27462076 C/T cg22903471 chr2:27725779 GCKR -0.42 -5.14 -0.3 5.24e-7 Blood metabolite levels; CESC cis rs7537660 1.000 rs6667389 chr1:248004614 C/T cg12080717 chr1:248004886 OR11L1 -0.41 -5.59 -0.32 5.52e-8 Platelet distribution width; CESC trans rs561341 0.714 rs547473 chr17:30297560 T/G cg20587970 chr11:113659929 NA -1.12 -14.24 -0.66 1.49e-34 Hip circumference adjusted for BMI; CESC trans rs10743315 0.643 rs17505214 chr12:19307139 A/G cg09562322 chr12:119419143 SRRM4 -0.5 -6.51 -0.37 3.67e-10 Gut microbiota (bacterial taxa); CESC cis rs8114671 0.562 rs6120757 chr20:33488771 C/T cg06115741 chr20:33292138 TP53INP2 0.45 5.37 0.31 1.71e-7 Height; CESC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg06108461 chr20:60628389 TAF4 -0.91 -14.02 -0.65 8.74e-34 Body mass index; CESC cis rs10752881 0.809 rs3768613 chr1:183106296 G/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.85e-31 Colorectal cancer; CESC cis rs116095464 0.558 rs28558836 chr5:285748 C/G cg22857025 chr5:266934 NA -1.27 -18.14 -0.74 2.35e-48 Breast cancer; CESC cis rs7772486 0.774 rs2247571 chr6:146219533 T/A cg23711669 chr6:146136114 FBXO30 0.65 9.31 0.5 4.9e-18 Lobe attachment (rater-scored or self-reported); CESC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg18099408 chr3:52552593 STAB1 -0.34 -5.88 -0.34 1.24e-8 Electroencephalogram traits; CESC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg00684032 chr4:1343700 KIAA1530 0.35 5.45 0.32 1.16e-7 Obesity-related traits; CESC cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg01475377 chr6:109611718 NA -0.52 -8.44 -0.46 2.16e-15 Reticulocyte fraction of red cells; CESC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.35e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs804280 1.000 rs804280 chr8:11612698 G/T cg12395012 chr8:11607386 GATA4 -0.53 -6.86 -0.39 4.82e-11 Myopia (pathological); CESC cis rs7264396 0.635 rs6058344 chr20:34475038 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -11.47 -0.58 5.38e-25 Total cholesterol levels; CESC cis rs4144743 1.000 rs34182248 chr17:45321359 T/C cg18085866 chr17:45331354 ITGB3 -0.65 -7.07 -0.4 1.39e-11 Body mass index; CESC cis rs9910055 0.664 rs433610 chr17:42197281 A/G cg19774624 chr17:42201019 HDAC5 0.75 11.24 0.57 3.24e-24 Total body bone mineral density; CESC cis rs11577318 0.853 rs7537477 chr1:26618829 C/T cg00852783 chr1:26633632 UBXN11 0.51 7.05 0.4 1.57e-11 Granulocyte percentage of myeloid white cells; CESC cis rs4319547 0.626 rs11057882 chr12:122875046 A/G cg05707623 chr12:122985044 ZCCHC8 -0.54 -6.14 -0.35 3.08e-9 Body mass index; CESC cis rs1595825 0.891 rs78198610 chr2:198522769 T/C cg10820045 chr2:198174542 NA 0.41 5.21 0.3 3.79e-7 Ulcerative colitis; CESC cis rs3733585 0.648 rs28513781 chr4:9959334 G/C cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs1421898 0.649 rs6556364 chr5:158157645 C/T cg19069039 chr12:52238665 NA -0.51 -6.14 -0.35 3.04e-9 Inflammatory skin disease; CESC cis rs6502050 0.723 rs4789698 chr17:80179786 C/T cg23985595 chr17:80112537 CCDC57 -0.37 -5.2 -0.3 4.04e-7 Life satisfaction; CESC cis rs61931739 0.782 rs7969373 chr12:34249655 T/G cg19457237 chr12:34500585 NA -0.42 -5.72 -0.33 2.86e-8 Morning vs. evening chronotype; CESC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg00129232 chr17:37814104 STARD3 -0.55 -7.23 -0.41 5.28e-12 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.570 rs1869351 chr4:99077286 T/C cg07917127 chr4:99064746 C4orf37 0.4 5.05 0.3 8.3e-7 Colonoscopy-negative controls vs population controls; CESC cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.75 0.47 2.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2797160 0.967 rs4897151 chr6:125993202 T/G cg05901451 chr6:126070800 HEY2 -0.45 -6.62 -0.38 1.93e-10 Endometrial cancer; CESC cis rs7647973 0.566 rs57630346 chr3:49086215 T/C cg07636037 chr3:49044803 WDR6 0.85 11.23 0.57 3.3e-24 Menarche (age at onset); CESC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg24829409 chr8:58192753 C8orf71 -0.49 -6.07 -0.35 4.47e-9 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg26314531 chr2:26401878 FAM59B 0.8 8.22 0.45 9.18e-15 Gut microbiome composition (summer); CESC cis rs7923609 0.875 rs10761741 chr10:65066186 G/T cg01631684 chr10:65280961 REEP3 -0.42 -5.3 -0.31 2.44e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs6570726 0.818 rs9390338 chr6:145908265 A/G cg05347473 chr6:146136440 FBXO30 0.57 7.44 0.42 1.37e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6546550 0.867 rs1048266 chr2:70132676 A/G cg02498382 chr2:70120550 SNRNP27 -0.41 -7.26 -0.41 4.34e-12 Prevalent atrial fibrillation; CESC cis rs1153858 1.000 rs2467858 chr15:45711492 A/G cg21132104 chr15:45694354 SPATA5L1 0.76 10.15 0.53 1.12e-20 Homoarginine levels; CESC cis rs4481887 0.893 rs28787378 chr1:248504447 C/T cg00666640 chr1:248458726 OR2T12 0.35 6.01 0.35 6.07e-9 Common traits (Other); CESC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg22638593 chr5:131593259 PDLIM4 0.39 5.12 0.3 5.97e-7 Breast cancer; CESC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg04944784 chr2:26401820 FAM59B -0.66 -7.62 -0.42 4.5e-13 Gut microbiome composition (summer); CESC cis rs1550582 1.000 rs7822348 chr8:135542483 C/G cg17885191 chr8:135476712 NA 0.58 6.8 0.39 6.89e-11 Educational attainment; CESC cis rs4253772 0.513 rs11090863 chr22:46705407 C/T cg18190219 chr22:46762943 CELSR1 -0.56 -5.46 -0.32 1.12e-7 LDL cholesterol;Cholesterol, total; CESC cis rs75477785 1.000 rs1856161 chr1:209959168 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.81 5.47 0.32 1.04e-7 Cleft lip with or without cleft palate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00432497 chr16:89438714 ANKRD11 0.42 6.2 0.36 2.16e-9 Gambling; CESC cis rs826838 0.806 rs826873 chr12:39121305 G/A cg26384229 chr12:38710491 ALG10B -0.67 -11.02 -0.56 1.72e-23 Heart rate; CESC cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg10523679 chr1:76189770 ACADM 0.73 8.63 0.47 5.66e-16 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg06634786 chr22:41940651 POLR3H -0.67 -6.8 -0.39 6.74e-11 Vitiligo; CESC cis rs8060686 0.565 rs11555011 chr16:68088485 A/G cg26727032 chr16:67993705 SLC12A4 -0.55 -6.15 -0.35 2.9e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg21138405 chr5:131827807 IRF1 -0.39 -5.75 -0.33 2.48e-8 Breast cancer;Mosquito bite size; CESC cis rs6754311 0.550 rs10173394 chr2:136522675 C/T cg15123519 chr2:136567270 LCT 0.33 5.54 0.32 7.14e-8 Mosquito bite size; CESC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.42e-7 Lung cancer; CESC cis rs7923609 0.934 rs10822153 chr10:65056813 C/A cg01631684 chr10:65280961 REEP3 -0.43 -5.41 -0.32 1.4e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs11864453 1.000 rs11864453 chr16:72050480 C/T cg16558253 chr16:72132732 DHX38 -0.5 -7.28 -0.41 3.73e-12 Fibrinogen levels; CESC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg04772025 chr11:68637568 NA 0.49 5.92 0.34 9.91e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13064411 0.597 rs2291905 chr3:113010466 C/T cg18753928 chr3:113234510 CCDC52 -0.39 -5.08 -0.3 7.21e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs4319547 0.760 rs61954973 chr12:123074168 T/C cg05707623 chr12:122985044 ZCCHC8 -0.58 -6.75 -0.38 9.5e-11 Body mass index; CESC cis rs7818345 0.935 rs6990217 chr8:19276661 G/C cg11303988 chr8:19266685 CSGALNACT1 0.32 5.85 0.34 1.45e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs10465746 0.780 rs11163862 chr1:84355418 A/T cg10977910 chr1:84465055 TTLL7 -0.51 -7.17 -0.4 7.25e-12 Obesity-related traits; CESC cis rs3820928 0.874 rs7582251 chr2:227791703 G/T cg05526886 chr2:227700861 RHBDD1 -0.4 -5.2 -0.3 3.93e-7 Pulmonary function; CESC cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg09165964 chr15:75287851 SCAMP5 -0.76 -9.14 -0.49 1.69e-17 Blood trace element (Zn levels); CESC trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg15704280 chr7:45808275 SEPT13 -0.83 -13.12 -0.63 1.27e-30 Coronary artery disease; CESC trans rs1223629 1.000 rs12244826 chr10:95945985 G/T cg16346422 chr11:2920819 SLC22A18;SLC22A18AS -0.65 -6.0 -0.35 6.41e-9 Glucose homeostasis traits; CESC cis rs6831352 0.918 rs29001195 chr4:100054244 G/T cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.36 0.31 1.85e-7 Bipolar disorder; CESC cis rs5753037 0.653 rs131270 chr22:30149896 C/T cg01021169 chr22:30184971 ASCC2 -0.46 -6.36 -0.36 8.57e-10 Type 1 diabetes; CESC cis rs6460942 1.000 rs62448566 chr7:12403662 G/A cg06484146 chr7:12443880 VWDE -0.7 -8.15 -0.45 1.5e-14 Coronary artery disease; CESC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.71 0.38 1.17e-10 Bipolar disorder; CESC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 8.08 0.44 2.38e-14 Alzheimer's disease; CESC cis rs765787 0.530 rs11070444 chr15:45513121 T/C cg24006582 chr15:45444508 DUOX1 0.54 6.54 0.37 3.12e-10 Uric acid levels; CESC cis rs3806843 0.676 rs1583005 chr5:140031537 G/A cg26395211 chr5:140044315 WDR55 0.53 6.78 0.38 7.57e-11 Depressive symptoms (multi-trait analysis); CESC cis rs3105593 1.000 rs3101853 chr15:50848382 A/T cg08437265 chr15:50716283 USP8 -0.42 -5.5 -0.32 9.08e-8 QT interval; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19905802 chr11:62554200 TMEM179B;TAF6L -0.48 -6.62 -0.38 2.01e-10 Fibrinogen levels; CESC cis rs763121 0.962 rs138711 chr22:39139913 C/T cg06022373 chr22:39101656 GTPBP1 0.73 10.52 0.54 7.38e-22 Menopause (age at onset); CESC cis rs9325144 0.647 rs12229104 chr12:39110811 T/A cg26384229 chr12:38710491 ALG10B -0.51 -7.11 -0.4 1.06e-11 Morning vs. evening chronotype; CESC cis rs1707322 0.752 rs3811436 chr1:46125880 T/C cg06784218 chr1:46089804 CCDC17 0.41 7.12 0.4 1.04e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11098499 0.644 rs10012252 chr4:120559139 T/C cg25214090 chr10:38739885 LOC399744 0.63 8.89 0.48 9.66e-17 Corneal astigmatism; CESC cis rs8067545 1.000 rs3909258 chr17:19945819 C/G cg13482628 chr17:19912719 NA 0.44 5.85 0.34 1.42e-8 Schizophrenia; CESC cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6429082 0.608 rs4469707 chr1:235570634 T/C cg26050004 chr1:235667680 B3GALNT2 -0.54 -6.79 -0.38 7.46e-11 Adiposity; CESC cis rs2072732 0.861 rs67872056 chr1:2954165 C/T cg15211996 chr1:2936768 ACTRT2 0.34 6.04 0.35 5.27e-9 Plateletcrit; CESC cis rs4909189 1.000 rs62493649 chr7:158135556 C/G cg25566285 chr7:158114605 PTPRN2 0.44 5.97 0.34 7.51e-9 Response to amphetamines; CESC trans rs10776614 0.799 rs7350439 chr10:49765574 A/G cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs17209837 1.000 rs4148814 chr7:87091543 T/C cg00919237 chr7:87102261 ABCB4 -0.51 -5.85 -0.34 1.46e-8 Gallbladder cancer; CESC cis rs17376456 0.542 rs10061069 chr5:93071630 G/C cg25358565 chr5:93447407 FAM172A 0.47 5.16 0.3 4.73e-7 Diabetic retinopathy; CESC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg06808227 chr14:105710500 BRF1 -0.6 -6.83 -0.39 5.75e-11 Mean platelet volume;Platelet distribution width; CESC cis rs9399135 0.684 rs1135205 chr6:135281795 C/T cg24558204 chr6:135376177 HBS1L 0.54 7.39 0.41 1.98e-12 Red blood cell count; CESC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg02071572 chr4:1403502 NA 0.34 5.05 0.3 8.37e-7 Longevity; CESC cis rs3126085 0.935 rs11204939 chr1:152200942 G/C cg03465714 chr1:152285911 FLG -0.43 -5.4 -0.31 1.48e-7 Atopic dermatitis; CESC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.75 7.68 0.43 3.04e-13 Platelet count; CESC cis rs72781680 0.821 rs72796361 chr2:24160689 A/T cg08917208 chr2:24149416 ATAD2B 0.63 6.24 0.36 1.73e-9 Lymphocyte counts; CESC cis rs3091242 0.933 rs1534954 chr1:25761924 A/T cg02931644 chr1:25747376 RHCE 0.43 7.21 0.41 5.74e-12 Erythrocyte sedimentation rate; CESC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg12463550 chr7:65579703 CRCP 0.56 7.02 0.4 1.9e-11 Aortic root size; CESC cis rs2652822 0.935 rs12148069 chr15:63443792 A/T cg02713581 chr15:63449717 RPS27L 0.58 7.51 0.42 8.81e-13 Metabolic traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26155979 chr10:105110866 PCGF6 0.62 6.86 0.39 4.72e-11 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg22535103 chr8:58192502 C8orf71 -1.05 -12.84 -0.62 1.17e-29 Developmental language disorder (linguistic errors); CESC cis rs977987 0.806 rs11862684 chr16:75461746 T/G cg03315344 chr16:75512273 CHST6 0.41 5.93 0.34 9.41e-9 Dupuytren's disease; CESC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg19592336 chr6:28129416 ZNF389 0.61 8.17 0.45 1.28e-14 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02933375 chr17:78858828 RPTOR -0.66 -7.25 -0.41 4.53e-12 Gut microbiome composition (summer); CESC cis rs4076764 0.914 rs6689760 chr1:163358704 A/G cg24596788 chr1:163392923 NA 0.49 7.32 0.41 3.06e-12 Motion sickness; CESC cis rs714031 0.934 rs4820386 chr22:40068051 C/T cg21377881 chr22:40064566 CACNA1I -0.32 -5.09 -0.3 6.65e-7 Schizophrenia; CESC cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg15556689 chr8:8085844 FLJ10661 0.53 6.45 0.37 5.3e-10 Mood instability; CESC cis rs17376456 0.877 rs10064520 chr5:93427358 T/C cg25358565 chr5:93447407 FAM172A 1.18 11.22 0.57 3.75e-24 Diabetic retinopathy; CESC cis rs4660261 0.562 rs3011223 chr1:44318286 T/C cg13606994 chr1:44402422 ARTN -0.35 -5.16 -0.3 4.91e-7 Intelligence (multi-trait analysis); CESC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg24829409 chr8:58192753 C8orf71 -0.59 -7.26 -0.41 4.34e-12 Developmental language disorder (linguistic errors); CESC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.26 -0.31 3.03e-7 Gut microbiome composition (summer); CESC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg22535103 chr8:58192502 C8orf71 -0.93 -10.31 -0.53 3.63e-21 Developmental language disorder (linguistic errors); CESC cis rs863345 0.604 rs975118 chr1:158511445 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -7.02 -0.4 1.89e-11 Pneumococcal bacteremia; CESC cis rs36051895 0.632 rs10815165 chr9:5149138 T/C cg02405213 chr9:5042618 JAK2 -0.54 -6.92 -0.39 3.39e-11 Pediatric autoimmune diseases; CESC cis rs11958404 0.615 rs7704746 chr5:157450601 C/G cg05962755 chr5:157440814 NA 0.38 5.65 0.33 4.06e-8 IgG glycosylation; CESC cis rs3096299 1.000 rs3096299 chr16:89448663 G/A cg08822215 chr16:89438651 ANKRD11 -0.43 -6.58 -0.37 2.46e-10 Multiple myeloma (IgH translocation); CESC cis rs1008375 0.932 rs4698627 chr4:17605959 T/C cg27347728 chr4:17578864 LAP3 0.43 5.29 0.31 2.51e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs17685 0.712 rs7778735 chr7:75770237 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.41 0.61 3.51e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs11098499 0.954 rs10017543 chr4:120321420 G/A cg09307838 chr4:120376055 NA 0.91 12.34 0.6 5.98e-28 Corneal astigmatism; CESC cis rs9640161 0.742 rs2159236 chr7:150017214 A/G cg21361702 chr7:150065534 REPIN1 0.57 6.72 0.38 1.1e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs155076 1.000 rs261431 chr13:21865738 A/G cg11317459 chr13:21872234 NA 1.05 12.46 0.61 2.33e-28 White matter hyperintensity burden; CESC cis rs11583043 1.000 rs6682873 chr1:101470906 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.53 5.78 0.33 2.1e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs1784581 0.802 rs2156747 chr6:162430000 C/G cg17173639 chr6:162384350 PARK2 -0.63 -10.06 -0.53 2.2e-20 Itch intensity from mosquito bite; CESC cis rs9457247 0.967 rs430145 chr6:167410369 C/T cg25258033 chr6:167368657 RNASET2 0.4 6.14 0.35 2.93e-9 Crohn's disease; CESC cis rs11098499 0.874 rs7661020 chr4:120106982 T/C cg09307838 chr4:120376055 NA 0.67 8.17 0.45 1.26e-14 Corneal astigmatism; CESC cis rs3820928 0.874 rs7605032 chr2:227847630 T/G cg11843606 chr2:227700838 RHBDD1 -0.45 -5.83 -0.34 1.63e-8 Pulmonary function; CESC cis rs367615 0.506 rs2963021 chr5:108800365 C/T cg17395555 chr5:108820864 NA 0.56 9.53 0.51 1.04e-18 Colorectal cancer (SNP x SNP interaction); CESC cis rs1881797 0.932 rs2387038 chr1:247674919 G/A cg18198730 chr1:247681584 NA 0.62 7.72 0.43 2.39e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs17376456 0.690 rs6892055 chr5:93113023 A/T cg25358565 chr5:93447407 FAM172A 1.07 10.4 0.54 1.79e-21 Diabetic retinopathy; CESC cis rs8005677 0.828 rs57822749 chr14:23409967 G/A cg01529538 chr14:23388837 RBM23 0.44 5.83 0.34 1.63e-8 Cognitive ability (multi-trait analysis); CESC cis rs12893668 0.703 rs35026580 chr14:104042753 A/G cg24130564 chr14:104152367 KLC1 -0.46 -5.62 -0.33 4.76e-8 Reticulocyte count; CESC cis rs722599 0.683 rs8008475 chr14:75291900 C/T cg08847533 chr14:75593920 NEK9 0.49 6.07 0.35 4.49e-9 IgG glycosylation; CESC cis rs7818688 0.745 rs11779282 chr8:95945487 A/G cg16049864 chr8:95962084 TP53INP1 0.54 5.33 0.31 2.14e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs933688 1.000 rs2059208 chr5:90732065 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 12.4 0.61 3.9e-28 Smoking behavior; CESC cis rs7772486 0.846 rs1854901 chr6:146325685 T/C cg05347473 chr6:146136440 FBXO30 0.51 6.68 0.38 1.4e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18462168 chr15:22892545 CYFIP1 -0.43 -6.57 -0.37 2.58e-10 Gambling; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18585642 chr15:75494022 C15orf39 -0.48 -6.02 -0.35 5.76e-9 Ulcerative colitis; CESC cis rs9302635 0.513 rs8050238 chr16:72154187 C/T cg01557791 chr16:72042693 DHODH -0.56 -6.48 -0.37 4.4e-10 Blood protein levels; CESC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg08109568 chr15:31115862 NA 0.68 9.49 0.5 1.38e-18 Huntington's disease progression; CESC cis rs1953600 0.870 rs2245168 chr10:81921918 T/C cg00277334 chr10:82204260 NA -0.43 -5.99 -0.35 6.85e-9 Sarcoidosis; CESC trans rs9467711 0.606 rs9379856 chr6:26366836 A/C cg06606381 chr12:133084897 FBRSL1 -0.76 -6.82 -0.39 6.01e-11 Autism spectrum disorder or schizophrenia; CESC cis rs2243480 1.000 rs56985706 chr7:65394562 C/T cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg22143856 chr6:28129313 ZNF389 0.38 5.38 0.31 1.6e-7 Cardiac Troponin-T levels; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg11000221 chr17:57643293 DHX40 0.49 6.26 0.36 1.55e-9 Retinol levels; CESC cis rs12586317 0.576 rs12586302 chr14:35691074 G/C cg16230307 chr14:35515116 FAM177A1 0.42 5.22 0.31 3.57e-7 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14094333 chr4:38666051 KLF3;FLJ13197 0.64 8.1 0.45 1.97e-14 Gut microbiome composition (summer); CESC cis rs2836633 0.929 rs8130434 chr21:40036243 C/T cg12884169 chr21:40033163 ERG -0.4 -6.41 -0.37 6.51e-10 Coronary artery disease; CESC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg26354017 chr1:205819088 PM20D1 0.76 11.09 0.56 1.03e-23 Menarche (age at onset); CESC cis rs12618769 0.597 rs3769729 chr2:99102810 T/C cg10123293 chr2:99228465 UNC50 0.41 5.44 0.32 1.24e-7 Bipolar disorder; CESC cis rs11785400 1.000 rs4484678 chr8:143730796 A/G cg24634471 chr8:143751801 JRK 0.45 5.89 0.34 1.15e-8 Schizophrenia; CESC cis rs6942407 0.546 rs7780698 chr7:86835731 T/G cg02420886 chr7:86849541 C7orf23 0.57 5.11 0.3 6.32e-7 Food allergy; CESC cis rs6736093 1.000 rs1967530 chr2:112659512 A/T cg12686935 chr2:112915763 FBLN7 -0.42 -5.17 -0.3 4.56e-7 Coronary artery disease; CESC cis rs9611565 0.921 rs5751080 chr22:41736267 A/G cg06481639 chr22:41940642 POLR3H -0.45 -5.21 -0.3 3.78e-7 Vitiligo; CESC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg10150615 chr22:24372951 LOC391322 -0.58 -8.04 -0.44 2.95e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7618501 0.521 rs868891 chr3:49949071 A/G cg24110177 chr3:50126178 RBM5 -0.52 -7.12 -0.4 1.04e-11 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19349143 chr22:47189686 TBC1D22A -0.55 -6.39 -0.37 7.28e-10 Gut microbiome composition (summer); CESC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg14393609 chr7:65229607 NA 0.46 6.06 0.35 4.71e-9 Aortic root size; CESC cis rs28647808 1.000 rs4962141 chr9:136274478 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs2000999 0.514 rs17604662 chr16:72221464 A/G cg04254540 chr16:71951199 KIAA0174 -0.67 -5.83 -0.34 1.58e-8 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC cis rs72901758 0.768 rs11655421 chr17:76251518 T/A cg23302638 chr17:76210176 BIRC5 0.47 5.06 0.3 7.71e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs599083 0.530 rs576118 chr11:68177708 C/T cg01657329 chr11:68192670 LRP5 0.44 5.29 0.31 2.57e-7 Bone mineral density (spine); CESC cis rs151234 0.565 rs9924471 chr16:28591530 G/A cg01378222 chr16:28622494 SULT1A1 -0.49 -7.59 -0.42 5.35e-13 Platelet distribution width; CESC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg12756686 chr19:29218302 NA 0.58 7.52 0.42 8.38e-13 Methadone dose in opioid dependence; CESC cis rs8072100 0.875 rs9635762 chr17:45648446 A/C cg08085267 chr17:45401833 C17orf57 0.4 5.16 0.3 4.87e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg19947233 chr4:90032727 TIGD2 0.54 6.91 0.39 3.51e-11 Breast cancer;Type 2 diabetes; CESC cis rs6782228 1.000 rs6782407 chr3:128338748 T/C cg15607142 chr3:128420513 NA -0.38 -5.09 -0.3 6.84e-7 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; CESC cis rs67311347 1.000 rs4246666 chr3:40407670 C/T cg24209194 chr3:40518798 ZNF619 0.46 6.03 0.35 5.43e-9 Renal cell carcinoma; CESC cis rs68170813 0.521 rs61673847 chr7:106892431 A/G cg02696742 chr7:106810147 HBP1 -0.52 -5.08 -0.3 7.2e-7 Coronary artery disease; CESC cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg08564027 chr20:61660810 NA 0.9 15.37 0.69 1.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs9479482 0.967 rs13209192 chr6:150350099 A/G cg03788504 chr6:150331562 NA -0.3 -5.79 -0.33 2.01e-8 Alopecia areata; CESC cis rs9457247 0.967 rs430145 chr6:167410369 C/T cg07741184 chr6:167504864 NA 0.3 5.52 0.32 8.06e-8 Crohn's disease; CESC cis rs11098499 0.779 rs7356491 chr4:120381974 C/T cg09307838 chr4:120376055 NA 0.96 13.95 0.65 1.6e-33 Corneal astigmatism; CESC cis rs854765 0.583 rs4413022 chr17:17858280 G/C cg04398451 chr17:18023971 MYO15A -0.69 -9.86 -0.52 9.76e-20 Total body bone mineral density; CESC cis rs2732480 0.577 rs2450994 chr12:48721832 G/A cg04545296 chr12:48745243 ZNF641 0.36 6.27 0.36 1.49e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg19468946 chr17:37922297 IKZF3 0.4 5.17 0.3 4.69e-7 Glomerular filtration rate (creatinine); CESC cis rs7605827 0.897 rs6729018 chr2:15540676 A/G cg19274914 chr2:15703543 NA 0.36 6.4 0.37 7.05e-10 Educational attainment (years of education); CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg20151795 chr6:28129481 ZNF389 0.48 6.41 0.37 6.55e-10 Depression; CESC trans rs877282 0.853 rs4579862 chr10:753298 A/C cg22713356 chr15:30763199 NA 0.92 8.28 0.45 5.95e-15 Uric acid levels; CESC trans rs722599 0.748 rs2537824 chr14:75367349 T/C cg00095594 chr1:236228625 NID1 -0.4 -6.17 -0.35 2.6e-9 IgG glycosylation; CESC cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg18016565 chr1:150552671 MCL1 -0.42 -6.84 -0.39 5.45e-11 Tonsillectomy; CESC cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg05340658 chr4:99064831 C4orf37 0.66 9.01 0.48 4.1e-17 Colonoscopy-negative controls vs population controls; CESC cis rs4974559 0.947 rs6847321 chr4:1347374 C/T cg02980000 chr4:1222292 CTBP1 0.66 6.63 0.38 1.88e-10 Systolic blood pressure; CESC cis rs7216064 1.000 rs6504549 chr17:65888784 A/G cg12091567 chr17:66097778 LOC651250 -0.83 -9.57 -0.51 8.04e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg10523679 chr1:76189770 ACADM 0.8 11.03 0.56 1.58e-23 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.84 8.94 0.48 6.94e-17 Platelet count; CESC cis rs7116495 0.609 rs2155145 chr11:71719619 G/T cg18441811 chr11:71824068 C11orf51 -0.81 -5.37 -0.31 1.74e-7 Severe influenza A (H1N1) infection; CESC cis rs1707322 0.721 rs9793568 chr1:46130373 G/A cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10845606 1.000 rs10845605 chr12:12833468 T/C cg09462578 chr12:12878428 APOLD1 -0.64 -7.0 -0.39 2.15e-11 Systemic lupus erythematosus; CESC cis rs12477438 0.822 rs6727170 chr2:99588042 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -7.4 -0.41 1.81e-12 Chronic sinus infection; CESC trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -6.58 -0.37 2.44e-10 Systolic blood pressure; CESC cis rs782590 0.620 rs7596377 chr2:55888612 T/A cg18811423 chr2:55921094 PNPT1 -0.68 -10.2 -0.53 8.21e-21 Metabolic syndrome; CESC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg18225595 chr11:63971243 STIP1 0.51 5.06 0.3 7.82e-7 Mean platelet volume; CESC cis rs1211375 0.607 rs1203978 chr16:257211 A/C cg00126636 chr16:237282 NA 0.44 6.65 0.38 1.63e-10 Hematology traits;Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs1961456 0.542 rs75501607 chr8:18244753 C/T cg18736775 chr8:18248649 NAT2 -0.47 -5.35 -0.31 1.89e-7 Total cholesterol levels; CESC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg22903471 chr2:27725779 GCKR -0.55 -7.77 -0.43 1.69e-13 Total body bone mineral density; CESC cis rs7267979 1.000 rs6083825 chr20:25366424 T/C cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.88e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs1728785 0.688 rs698718 chr16:68560185 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.45 0.42 1.32e-12 Ulcerative colitis; CESC cis rs6484504 0.532 rs7116443 chr11:31283170 T/C cg14844989 chr11:31128820 NA -0.4 -5.54 -0.32 7.13e-8 Red blood cell count; CESC cis rs9916302 0.851 rs12936996 chr17:37665554 A/G cg00129232 chr17:37814104 STARD3 0.5 6.59 0.38 2.42e-10 Glomerular filtration rate (creatinine); CESC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.59 0.38 2.4e-10 Electroencephalogram traits; CESC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg26335602 chr6:28129616 ZNF389 0.37 5.46 0.32 1.09e-7 Cardiac Troponin-T levels; CESC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.64 -8.44 -0.46 2.15e-15 Tonsillectomy; CESC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg08859206 chr1:53392774 SCP2 -0.55 -6.95 -0.39 2.88e-11 Monocyte count; CESC cis rs11098499 0.863 rs7695620 chr4:120452776 G/A cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs7587476 0.784 rs17424051 chr2:215688992 G/C cg04004882 chr2:215674386 BARD1 0.53 5.83 0.34 1.61e-8 Neuroblastoma; CESC cis rs4253772 0.938 rs11704979 chr22:46632994 G/A cg18190219 chr22:46762943 CELSR1 -0.61 -5.84 -0.34 1.52e-8 LDL cholesterol;Cholesterol, total; CESC trans rs11098499 0.863 rs6833334 chr4:120504227 C/T cg25214090 chr10:38739885 LOC399744 0.66 8.85 0.48 1.28e-16 Corneal astigmatism; CESC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg05255149 chr17:80675120 FN3KRP -0.47 -5.42 -0.32 1.37e-7 Breast cancer; CESC cis rs10492096 0.947 rs11064231 chr12:6604415 T/G cg13857086 chr12:6580257 VAMP1 0.61 6.14 0.35 3.03e-9 Hip geometry; CESC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg18446336 chr7:2847575 GNA12 0.38 5.86 0.34 1.4e-8 Height; CESC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg17294928 chr15:75287854 SCAMP5 0.49 6.17 0.35 2.54e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs7903847 0.602 rs7916665 chr10:99157573 T/G cg20016023 chr10:99160130 RRP12 -0.3 -5.14 -0.3 5.27e-7 Granulocyte percentage of myeloid white cells; CESC cis rs2282802 0.711 rs3777095 chr5:139660916 G/A cg26211634 chr5:139558579 C5orf32 0.51 7.42 0.41 1.55e-12 Intelligence (multi-trait analysis); CESC cis rs11867934 0.532 rs7218795 chr17:17115566 A/G cg20098446 chr17:17120238 FLCN 0.39 6.03 0.35 5.37e-9 Diabetic retinopathy; CESC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg08888203 chr3:10149979 C3orf24 -0.46 -6.18 -0.35 2.41e-9 Alzheimer's disease; CESC cis rs1568889 0.641 rs34857148 chr11:28481976 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.53 5.27 0.31 2.82e-7 Bipolar disorder; CESC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg00684032 chr4:1343700 KIAA1530 -0.47 -6.8 -0.39 6.74e-11 Obesity-related traits; CESC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg18876405 chr7:65276391 NA 0.53 7.06 0.4 1.42e-11 Aortic root size; CESC cis rs6459788 0.585 rs6950818 chr7:157235364 C/G cg06271696 chr7:157225062 NA -0.44 -7.46 -0.42 1.23e-12 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21659725 chr3:3221576 CRBN -0.83 -13.35 -0.63 1.98e-31 Intelligence (multi-trait analysis); CESC cis rs2066819 1.000 rs2371454 chr12:56647243 A/G cg26714650 chr12:56694279 CS 1.52 10.39 0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs1665050 0.534 rs11858479 chr15:59242706 G/A cg05156742 chr15:59063176 FAM63B 0.49 6.19 0.36 2.33e-9 Atopic dermatitis; CESC cis rs7301826 0.610 rs4759789 chr12:131296380 A/C cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.49e-8 Plasma plasminogen activator levels; CESC cis rs10208940 0.920 rs34366735 chr2:68771995 A/G cg12452813 chr2:68675892 NA 0.51 5.11 0.3 6.17e-7 Urate levels in lean individuals; CESC cis rs1670533 0.932 rs6599276 chr4:1056827 T/C cg27284194 chr4:1044797 NA 0.48 6.0 0.35 6.44e-9 Recombination rate (females); CESC trans rs561341 1.000 rs542132 chr17:30307193 A/T cg20587970 chr11:113659929 NA -1.41 -18.23 -0.75 1.08e-48 Hip circumference adjusted for BMI; CESC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg11890956 chr21:40555474 PSMG1 1.11 17.58 0.73 2.21e-46 Cognitive function; CESC cis rs17433780 0.964 rs12121223 chr1:89481583 C/T cg09516651 chr1:89888402 LOC400759 0.67 9.07 0.49 2.69e-17 Carotid intima media thickness; CESC cis rs977987 0.835 rs7200616 chr16:75366089 G/A cg03315344 chr16:75512273 CHST6 0.39 5.52 0.32 7.99e-8 Dupuytren's disease; CESC cis rs7223966 1.000 rs112143304 chr17:61822401 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 5.17 0.3 4.67e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs10129255 0.957 rs12589190 chr14:107191316 C/T cg07958169 chr14:107095056 NA -0.4 -5.51 -0.32 8.54e-8 Kawasaki disease; CESC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.63 6.1 0.35 3.75e-9 Cerebrospinal P-tau181p levels; CESC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.6 0.51 6.43e-19 Platelet count; CESC cis rs9796 0.558 rs8043253 chr15:41503730 C/T cg18705301 chr15:41695430 NDUFAF1 -0.47 -6.94 -0.39 2.93e-11 Menopause (age at onset); CESC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg17724175 chr1:150552817 MCL1 0.42 6.42 0.37 6.31e-10 Melanoma; CESC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.84 9.0 0.48 4.4e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09060823 chr12:56862504 SPRYD4 -0.45 -6.4 -0.37 7.2e-10 Gambling; CESC cis rs6120849 0.951 rs6120848 chr20:33728678 T/C cg24642439 chr20:33292090 TP53INP2 0.65 6.77 0.38 8.37e-11 Protein C levels; CESC cis rs3862260 0.509 rs7552885 chr1:120164966 C/T cg16322792 chr1:120165303 ZNF697 0.58 10.95 0.56 2.82e-23 Systemic lupus erythematosus; CESC cis rs72945132 0.825 rs72947052 chr11:70188575 A/G cg14191688 chr11:70257035 CTTN 0.57 6.33 0.36 1.02e-9 Coronary artery disease; CESC cis rs2635047 0.777 rs9944807 chr18:44788908 A/G cg24371990 chr18:44770781 NA 0.42 6.57 0.37 2.61e-10 Educational attainment; CESC cis rs5758659 0.652 rs1063392 chr22:42454950 C/T cg15557168 chr22:42548783 NA 0.47 7.51 0.42 9.02e-13 Cognitive function; CESC cis rs2011503 0.941 rs72999063 chr19:19380596 G/T cg11584989 chr19:19387371 SF4 0.6 7.21 0.4 5.96e-12 Bipolar disorder; CESC cis rs546131 0.820 rs744841 chr11:34857667 G/A cg22717608 chr11:34937665 PDHX;APIP -0.42 -5.31 -0.31 2.35e-7 Lung disease severity in cystic fibrosis; CESC cis rs4789693 1.000 rs4789693 chr17:80421870 A/C cg04308225 chr17:80449738 NA 0.43 5.12 0.3 5.88e-7 Glucocorticoid-induced osteonecrosis; CESC cis rs10751667 0.600 rs14346 chr11:1011829 T/C cg01483505 chr11:975446 AP2A2 0.42 5.4 0.31 1.51e-7 Alzheimer's disease (late onset); CESC cis rs9287719 0.967 rs6748036 chr2:10717489 C/T cg02196655 chr2:10830764 NOL10 -0.36 -5.63 -0.33 4.61e-8 Prostate cancer; CESC cis rs13223928 0.605 rs10951052 chr7:3155301 A/G cg19214707 chr7:3157722 NA -0.38 -5.17 -0.3 4.69e-7 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg19592336 chr6:28129416 ZNF389 0.51 6.86 0.39 4.96e-11 Depression; CESC cis rs72781680 1.000 rs72781631 chr2:24195064 G/A cg08917208 chr2:24149416 ATAD2B 0.94 8.73 0.47 2.91e-16 Lymphocyte counts; CESC cis rs8103278 0.507 rs10401971 chr19:46261982 C/T cg12641515 chr19:46296257 DMWD 0.74 9.95 0.52 4.96e-20 Coronary artery disease; CESC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg00149659 chr3:10157352 C3orf10 0.72 9.04 0.49 3.45e-17 Alzheimer's disease; CESC cis rs4423214 1.000 rs12278461 chr11:71182185 C/T cg24826892 chr11:71159390 DHCR7 0.46 5.24 0.31 3.33e-7 Vitamin D levels; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg13683516 chr12:56618066 OBFC2B 0.53 6.18 0.35 2.41e-9 Psoriatic arthritis; CESC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.33 0.31 2.11e-7 Tonsillectomy; CESC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg13607699 chr17:42295918 UBTF 0.58 7.4 0.41 1.76e-12 Total body bone mineral density; CESC cis rs9811920 0.809 rs793464 chr3:99626028 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.43 5.64 0.33 4.43e-8 Axial length; CESC cis rs9926296 0.542 rs12599531 chr16:89909401 C/T cg03605463 chr16:89740564 NA 0.46 5.24 0.31 3.35e-7 Vitiligo; CESC cis rs2180341 1.000 rs2038378 chr6:127590400 C/T cg27446573 chr6:127587934 RNF146 1.07 15.89 0.7 2.11e-40 Breast cancer; CESC cis rs3820068 0.581 rs61056912 chr1:15926296 A/G cg13390004 chr1:15929781 NA 0.34 5.45 0.32 1.13e-7 Systolic blood pressure; CESC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg01416388 chr22:39784598 NA -0.55 -7.1 -0.4 1.17e-11 Intelligence (multi-trait analysis); CESC cis rs11792861 0.926 rs72607172 chr9:111876523 A/G cg13535736 chr9:111863775 C9orf5 -0.5 -6.65 -0.38 1.64e-10 Menarche (age at onset); CESC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg04025307 chr7:1156635 C7orf50 0.45 7.44 0.42 1.41e-12 Longevity;Endometriosis; CESC cis rs4474465 0.688 rs7124803 chr11:78280822 T/G cg27205649 chr11:78285834 NARS2 0.53 7.17 0.4 7.43e-12 Alzheimer's disease (survival time); CESC cis rs10752881 0.935 rs4652771 chr1:183023503 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.5 0.64 6.03e-32 Colorectal cancer; CESC cis rs3771570 1.000 rs62186422 chr2:242249499 A/G cg21155796 chr2:242212141 HDLBP 0.61 5.29 0.31 2.55e-7 Prostate cancer; CESC cis rs56399783 0.901 rs73049327 chr7:2795544 T/G cg19731401 chr7:2775893 GNA12 0.63 5.82 0.34 1.69e-8 Childhood ear infection; CESC cis rs4722585 0.605 rs3753098 chr7:26198040 C/T cg07876897 chr7:26191696 NFE2L3 -0.48 -6.01 -0.35 6.19e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); CESC cis rs7100689 0.784 rs7081903 chr10:82162509 T/C cg00277334 chr10:82204260 NA -0.59 -7.32 -0.41 3.05e-12 Post bronchodilator FEV1; CESC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg18301423 chr5:131593218 PDLIM4 0.38 5.41 0.32 1.4e-7 Breast cancer; CESC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg19077165 chr18:44547161 KATNAL2 -0.62 -9.56 -0.51 8.74e-19 Personality dimensions; CESC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg01939980 chr4:1354348 KIAA1530 0.44 5.26 0.31 2.9e-7 Longevity; CESC cis rs2228479 0.850 rs17233664 chr16:89810628 C/T cg04013166 chr16:89971882 TCF25 0.77 6.69 0.38 1.32e-10 Skin colour saturation; CESC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg05552183 chr6:42928497 GNMT 0.75 11.48 0.58 4.79e-25 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7551222 0.752 rs12138846 chr1:204556478 T/A cg20240347 chr1:204465584 NA -0.29 -5.97 -0.34 7.54e-9 Schizophrenia; CESC cis rs4523957 0.928 rs441750 chr17:2190767 T/C cg16513277 chr17:2031491 SMG6 0.59 8.07 0.44 2.51e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7568498 0.517 rs197261 chr2:161904823 A/G cg21518248 chr2:162101506 NA -0.49 -5.14 -0.3 5.45e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs4481887 0.861 rs4575112 chr1:248473534 A/G cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs10751667 0.621 rs10794351 chr11:946228 C/T cg06064525 chr11:970664 AP2A2 -0.49 -9.76 -0.51 2.01e-19 Alzheimer's disease (late onset); CESC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg08736216 chr1:53307985 ZYG11A -0.39 -6.36 -0.36 8.73e-10 Monocyte count; CESC cis rs61931739 0.534 rs28548399 chr12:34188151 G/A cg19457237 chr12:34500585 NA -0.39 -5.39 -0.31 1.53e-7 Morning vs. evening chronotype; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg12419862 chr22:24373484 LOC391322 -0.87 -13.03 -0.62 2.47e-30 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1729951 0.575 rs361242 chr3:136698330 C/G cg25687071 chr3:136751404 NA 0.41 5.37 0.31 1.68e-7 Neuroticism; CESC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg25036284 chr2:26402008 FAM59B 0.67 7.28 0.41 3.75e-12 Gut microbiome composition (summer); CESC cis rs11190604 1.000 rs11190587 chr10:102266638 C/T cg07080220 chr10:102295463 HIF1AN 0.62 5.63 0.33 4.62e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs1018836 0.923 rs7007102 chr8:91629730 T/A cg16814680 chr8:91681699 NA -0.72 -9.95 -0.52 4.95e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs853679 0.599 rs202906 chr6:28011652 C/T cg23372001 chr6:27791640 HIST1H4J -0.62 -5.1 -0.3 6.6e-7 Depression; CESC cis rs9435341 0.929 rs1730865 chr1:107605611 A/C cg09367891 chr1:107599246 PRMT6 0.67 8.13 0.45 1.64e-14 Facial morphology (factor 21, depth of nasal alae); CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg03404566 chr17:6899310 ALOX12 0.38 6.41 0.37 6.71e-10 Tonsillectomy; CESC cis rs7605827 0.930 rs2058866 chr2:15519992 G/T cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs1005277 0.589 rs2749624 chr10:38529865 A/G cg00409905 chr10:38381863 ZNF37A -0.51 -6.84 -0.39 5.62e-11 Extrinsic epigenetic age acceleration; CESC cis rs9916302 0.861 rs11078913 chr17:37671714 G/T cg20243544 chr17:37824526 PNMT 0.45 5.68 0.33 3.61e-8 Glomerular filtration rate (creatinine); CESC cis rs8141529 0.732 rs2347447 chr22:29179739 C/A cg02153584 chr22:29168773 CCDC117 0.69 9.89 0.52 7.6e-20 Lymphocyte counts; CESC cis rs9399137 0.507 rs6940258 chr6:135366132 C/T cg22676075 chr6:135203613 NA 0.53 7.14 0.4 9.06e-12 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7100689 0.646 rs10736347 chr10:82134465 G/A cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs10504229 0.511 rs16921553 chr8:57979314 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -6.24 -0.36 1.74e-9 Developmental language disorder (linguistic errors); CESC cis rs7818688 0.697 rs112076731 chr8:95978121 C/G cg16049864 chr8:95962084 TP53INP1 0.57 5.73 0.33 2.79e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs367943 1.000 rs168366 chr5:112818587 C/T cg12552261 chr5:112820674 MCC 0.64 8.14 0.45 1.55e-14 Type 2 diabetes; CESC cis rs2832191 0.655 rs2247110 chr21:30323888 G/A cg24692254 chr21:30365293 RNF160 -0.99 -17.3 -0.73 2.13e-45 Dental caries; CESC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg04166393 chr7:2884313 GNA12 0.6 7.7 0.43 2.75e-13 Height; CESC cis rs9486715 0.867 rs2223238 chr6:96871855 G/A cg18709589 chr6:96969512 KIAA0776 0.45 6.42 0.37 6.42e-10 Headache; CESC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg02569458 chr12:86230093 RASSF9 -0.5 -7.23 -0.41 5.12e-12 Major depressive disorder; CESC cis rs644799 0.544 rs498553 chr11:95534441 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.57 7.57 0.42 6.3e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3126085 0.877 rs3126055 chr1:152266364 G/A cg03465714 chr1:152285911 FLG 0.48 5.94 0.34 9.06e-9 Atopic dermatitis; CESC cis rs57506017 0.585 rs11509153 chr7:12263800 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.47e-7 Neuroticism; CESC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg18876405 chr7:65276391 NA 0.56 7.48 0.42 1.06e-12 Aortic root size; CESC trans rs561341 0.883 rs7219239 chr17:30212016 A/G cg20587970 chr11:113659929 NA 0.99 11.71 0.58 8.33e-26 Hip circumference adjusted for BMI; CESC cis rs1448094 0.817 rs12370270 chr12:86343303 T/G cg02569458 chr12:86230093 RASSF9 0.41 5.9 0.34 1.12e-8 Major depressive disorder; CESC cis rs9943753 0.508 rs2075433 chr12:109833920 A/G cg19025524 chr12:109796872 NA -0.47 -6.66 -0.38 1.61e-10 HDL cholesterol; CESC cis rs559928 0.606 rs61083753 chr11:63892665 C/T cg18225595 chr11:63971243 STIP1 0.66 6.6 0.38 2.24e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs4555082 0.834 rs4412909 chr14:105759226 T/C cg06808227 chr14:105710500 BRF1 -0.56 -6.42 -0.37 6.43e-10 Mean platelet volume;Platelet distribution width; CESC cis rs459571 0.920 rs2520094 chr9:136919985 A/T cg13789015 chr9:136890014 NCRNA00094 0.53 7.43 0.42 1.52e-12 Platelet distribution width; CESC cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg22467129 chr15:76604101 ETFA -0.38 -5.7 -0.33 3.15e-8 Blood metabolite levels; CESC cis rs6815814 0.950 rs114719937 chr4:38808585 G/C cg02016764 chr4:38805732 TLR1 -0.63 -7.26 -0.41 4.22e-12 Breast cancer; CESC cis rs9611519 1.000 rs6002271 chr22:41566595 C/T cg03806693 chr22:41940476 POLR3H -0.57 -5.84 -0.34 1.56e-8 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23063716 chr15:75743999 SIN3A 0.52 6.23 0.36 1.78e-9 Gut microbiome composition (summer); CESC cis rs9467711 0.606 rs9357006 chr6:26364628 A/C cg14345882 chr6:26364793 BTN3A2 0.62 6.53 0.37 3.29e-10 Autism spectrum disorder or schizophrenia; CESC cis rs1707322 0.721 rs10890336 chr1:46111056 C/T cg03146154 chr1:46216737 IPP 0.82 11.49 0.58 4.71e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7615952 0.673 rs9821905 chr3:125620850 A/G cg07211511 chr3:129823064 LOC729375 0.8 7.96 0.44 4.92e-14 Blood pressure (smoking interaction); CESC cis rs4076764 0.914 rs6689760 chr1:163358704 A/G cg06092702 chr1:163392909 NA 0.4 5.94 0.34 9.03e-9 Motion sickness; CESC cis rs1003719 0.762 rs4399800 chr21:38489478 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs55692411 0.537 rs35375092 chr3:50065274 G/A cg24308560 chr3:49941425 MST1R -0.54 -6.64 -0.38 1.79e-10 Intelligence (multi-trait analysis); CESC cis rs6060960 0.502 rs15817 chr20:30193538 A/G cg13852791 chr20:30311386 BCL2L1 0.67 6.71 0.38 1.2e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00789004 chr19:44143830 CADM4 0.64 7.03 0.4 1.8e-11 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08165151 chr6:88411075 NCRNA00120;AKIRIN2 -0.43 -6.08 -0.35 4.1e-9 Gambling; CESC cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg11941060 chr3:133502564 NA -0.53 -7.18 -0.4 6.91e-12 Iron status biomarkers; CESC trans rs17039065 0.920 rs7695026 chr4:109436476 G/A cg27151770 chr16:49620536 ZNF423 -0.51 -6.21 -0.36 2.09e-9 Gut microbiome composition (summer); CESC cis rs1030268 0.505 rs77112963 chr7:133259399 G/A cg10665199 chr7:133106180 EXOC4 0.52 5.45 0.32 1.14e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10777881 chr1:144044138 NA -0.6 -6.33 -0.36 1.03e-9 Gut microbiome composition (summer); CESC cis rs6938 0.563 rs12917376 chr15:75116167 C/T cg17294928 chr15:75287854 SCAMP5 0.51 6.56 0.37 2.8e-10 Breast cancer; CESC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg27297192 chr10:134578999 INPP5A 0.4 5.13 0.3 5.72e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4423214 0.819 rs7938885 chr11:71170043 T/C cg05163923 chr11:71159392 DHCR7 0.83 11.29 0.57 2.17e-24 Vitamin D levels; CESC cis rs6089829 1.000 rs6089828 chr20:61668998 C/T cg16240275 chr20:61666158 NCRNA00029 0.47 8.2 0.45 1.06e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs1055129 0.537 rs2467100 chr17:73949038 C/G cg02678768 chr17:74002944 EVPL 0.4 5.56 0.32 6.56e-8 White matter hyperintensity burden; CESC cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg26408565 chr15:76604113 ETFA -0.42 -6.19 -0.36 2.27e-9 Blood metabolite levels; CESC cis rs9308433 0.569 rs1353718 chr1:214459652 A/T cg06198575 chr1:214491504 SMYD2 0.44 5.17 0.3 4.56e-7 IgG glycosylation; CESC cis rs10791323 0.604 rs2853115 chr11:133707908 C/T cg15485101 chr11:133734466 NA -0.39 -6.52 -0.37 3.63e-10 Childhood ear infection; CESC cis rs1976403 0.633 rs1780324 chr1:21821757 A/G cg21906605 chr1:21766650 NBPF3 0.39 5.08 0.3 7.07e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7605378 0.658 rs4673507 chr2:200710167 G/C cg23649088 chr2:200775458 C2orf69 0.64 8.68 0.47 3.97e-16 Osteoporosis; CESC cis rs672059 0.812 rs61418038 chr1:183155717 C/A ch.1.3577855R chr1:183094577 LAMC1 0.54 6.94 0.39 2.98e-11 Hypertriglyceridemia; CESC cis rs4704187 0.687 rs6869345 chr5:74378742 C/T cg03227963 chr5:74354835 NA 0.32 5.95 0.34 8.68e-9 Response to amphetamines; CESC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL -0.66 -6.06 -0.35 4.53e-9 Depression; CESC cis rs854765 0.583 rs4413022 chr17:17858280 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.07 0.44 2.47e-14 Total body bone mineral density; CESC trans rs6460942 0.524 rs6948366 chr7:12369905 A/G cg16269144 chr1:2003326 PRKCZ 0.54 6.53 0.37 3.39e-10 Coronary artery disease; CESC cis rs10489525 0.599 rs7516121 chr1:115604317 A/G cg12756093 chr1:115239321 AMPD1 -0.44 -5.29 -0.31 2.55e-7 Autism; CESC cis rs6496667 0.509 rs57962570 chr15:90985596 C/G cg10434728 chr15:90938212 IQGAP1 0.29 5.14 0.3 5.27e-7 Rheumatoid arthritis; CESC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.81 -11.44 -0.57 7.04e-25 Prudent dietary pattern; CESC cis rs7264396 0.563 rs2425114 chr20:34322346 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.86 0.39 4.77e-11 Total cholesterol levels; CESC cis rs863345 0.967 rs7550787 chr1:158469908 C/T cg12129480 chr1:158549410 OR10X1 -0.31 -6.13 -0.35 3.19e-9 Pneumococcal bacteremia; CESC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg17330251 chr7:94953956 PON1 -0.66 -10.45 -0.54 1.26e-21 Paraoxonase activity; CESC cis rs1400745 0.756 rs799682 chr14:35349984 G/C cg16230307 chr14:35515116 FAM177A1 0.44 5.24 0.31 3.23e-7 Monocyte count; CESC trans rs1814175 0.676 rs11040647 chr11:49935947 A/C cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs12971120 1.000 rs12971120 chr18:72174023 A/G cg25817165 chr18:72167213 CNDP2 -0.63 -8.05 -0.44 2.8e-14 Refractive error; CESC cis rs8060686 0.841 rs73594554 chr16:67920049 G/A cg26727032 chr16:67993705 SLC12A4 -0.57 -6.49 -0.37 4.28e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg26373071 chr5:1325741 CLPTM1L 0.41 6.43 0.37 5.91e-10 Lung cancer; CESC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.85 0.34 1.46e-8 Bipolar disorder; CESC cis rs9362426 0.672 rs12663865 chr6:88103149 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.48 5.62 0.33 4.82e-8 Depressive episodes in bipolar disorder; CESC cis rs4660306 1.000 rs2077808 chr1:45988115 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.72 -0.43 2.33e-13 Homocysteine levels; CESC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg24531977 chr5:56204891 C5orf35 -0.68 -9.3 -0.5 5.4e-18 Initial pursuit acceleration; CESC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg08392591 chr16:89556376 ANKRD11 0.59 8.03 0.44 3.27e-14 Multiple myeloma (IgH translocation); CESC cis rs9815354 0.767 rs73087378 chr3:41936827 G/A cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs35849525 0.814 rs7635601 chr3:50044006 A/T cg24308560 chr3:49941425 MST1R -0.52 -6.59 -0.38 2.32e-10 Intelligence (multi-trait analysis); CESC cis rs2592394 0.675 rs711819 chr2:176985696 C/T cg13092806 chr2:177043255 NA -0.48 -5.45 -0.32 1.15e-7 Magnesium levels;Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs12136530 0.550 rs3790768 chr1:19698501 G/T cg01832549 chr1:19774989 CAPZB -0.42 -5.41 -0.32 1.44e-7 Lead levels in blood; CESC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg00129232 chr17:37814104 STARD3 -0.78 -11.12 -0.56 8.06e-24 Asthma; CESC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.04 0.8 7.1e-62 Prudent dietary pattern; CESC cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg18225595 chr11:63971243 STIP1 0.51 6.7 0.38 1.24e-10 Platelet count; CESC cis rs2228479 0.850 rs11642010 chr16:89845111 T/C cg00800038 chr16:89945340 TCF25 -0.96 -7.49 -0.42 9.97e-13 Skin colour saturation; CESC cis rs796364 0.951 rs12463436 chr2:201061962 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.57 5.85 0.34 1.45e-8 Schizophrenia; CESC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg14558114 chr2:88469736 THNSL2 0.57 5.3 0.31 2.42e-7 Plasma clusterin levels; CESC cis rs858239 0.601 rs11982002 chr7:23163270 C/T cg23682824 chr7:23144976 KLHL7 0.54 7.39 0.41 1.91e-12 Cerebrospinal fluid biomarker levels; CESC cis rs12477438 0.834 rs11903311 chr2:99701807 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -9.91 -0.52 6.61e-20 Chronic sinus infection; CESC cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg12826209 chr6:26865740 GUSBL1 0.73 8.13 0.45 1.7e-14 Intelligence (multi-trait analysis); CESC cis rs5769707 0.839 rs73176988 chr22:49989649 G/T cg05373962 chr22:49881684 NA -0.36 -6.13 -0.35 3.16e-9 Monocyte count;Monocyte percentage of white cells; CESC cis rs10504229 0.834 rs7015674 chr8:58153166 C/T cg22535103 chr8:58192502 C8orf71 -0.9 -11.01 -0.56 1.78e-23 Developmental language disorder (linguistic errors); CESC cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg23711669 chr6:146136114 FBXO30 0.97 14.47 0.66 2.25e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs9840812 0.577 rs503973 chr3:136059537 C/G cg15507776 chr3:136538369 TMEM22 -0.54 -6.16 -0.35 2.67e-9 Fibrinogen levels; CESC cis rs7546094 1.000 rs2999154 chr1:113222456 G/T cg22162597 chr1:113214053 CAPZA1 -0.39 -6.0 -0.35 6.36e-9 Platelet distribution width; CESC trans rs1814175 0.645 rs12364337 chr11:49942580 A/T cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs2290159 0.948 rs5746255 chr3:12624321 A/G cg23032965 chr3:12705835 RAF1 0.53 6.05 0.35 4.85e-9 Cholesterol, total; CESC cis rs2832191 0.632 rs2246777 chr21:30309586 T/C cg08807101 chr21:30365312 RNF160 -0.9 -13.41 -0.64 1.22e-31 Dental caries; CESC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.02 0.8 8.62e-62 Prudent dietary pattern; CESC cis rs7219021 0.892 rs9913867 chr17:46849602 G/T cg16584676 chr17:46985605 UBE2Z -0.52 -5.91 -0.34 1.04e-8 Schizophrenia or bipolar disorder; CESC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg24503407 chr1:205819492 PM20D1 -0.46 -6.41 -0.37 6.51e-10 Menarche (age at onset); CESC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7662987 1.000 rs13145727 chr4:99998866 T/A cg13256891 chr4:100009986 ADH5 -0.83 -5.86 -0.34 1.38e-8 Smoking initiation; CESC cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.83 12.25 0.6 1.25e-27 Platelet count; CESC cis rs3213545 0.700 rs10849829 chr12:121470256 A/G cg25281562 chr12:121454272 C12orf43 -0.39 -5.1 -0.3 6.45e-7 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs12476592 0.602 rs2604613 chr2:63832776 G/A cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27365115 chr2:103353231 MFSD9 -0.49 -6.39 -0.37 7.5e-10 Fibrinogen levels; CESC cis rs60154123 0.730 rs583148 chr1:210463553 A/C cg23283495 chr1:209979779 IRF6 0.4 5.18 0.3 4.42e-7 Coronary artery disease; CESC cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg23711669 chr6:146136114 FBXO30 0.94 12.6 0.61 7.64e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs2075671 0.903 rs11979818 chr7:100293639 A/G cg16850897 chr7:100343110 ZAN 0.68 8.69 0.47 3.9e-16 Other erythrocyte phenotypes; CESC cis rs11690935 0.798 rs13018768 chr2:172598592 A/G cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.92 -0.68 6.05e-37 Schizophrenia; CESC cis rs9457247 0.565 rs2239824 chr6:167511799 T/A cg07741184 chr6:167504864 NA 0.43 7.69 0.43 2.96e-13 Crohn's disease; CESC cis rs9902453 0.845 rs2321331 chr17:28025528 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.53 0.46 1.15e-15 Coffee consumption (cups per day); CESC cis rs2625529 0.730 rs7177242 chr15:72184114 A/G cg16672083 chr15:72433130 SENP8 0.43 6.2 0.36 2.1e-9 Red blood cell count; CESC cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg16339924 chr4:17578868 LAP3 -0.69 -8.2 -0.45 1.05e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4141404 0.851 rs5749248 chr22:31683711 C/A cg13145458 chr22:31556086 RNF185 0.58 6.05 0.35 5.04e-9 Paclitaxel-induced neuropathy; CESC cis rs9913156 0.793 rs55682338 chr17:4582183 G/A cg00122941 chr17:4613640 ARRB2 0.84 9.76 0.51 2.01e-19 Lymphocyte counts; CESC cis rs3806933 0.522 rs11241100 chr5:110460958 C/T cg04022379 chr5:110408740 TSLP 0.45 7.36 0.41 2.27e-12 Eosinophilic esophagitis; CESC cis rs2228479 0.850 rs62056063 chr16:89903680 C/T cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs965469 1.000 rs6051838 chr20:3389012 A/C cg25506879 chr20:3388711 C20orf194 -0.57 -6.08 -0.35 4.29e-9 IFN-related cytopenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22734315 chr16:81069742 ATMIN -0.37 -6.23 -0.36 1.8e-9 Gambling; CESC cis rs727505 0.954 rs66526112 chr7:124504074 C/A cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg25427524 chr10:38739819 LOC399744 -0.65 -9.48 -0.5 1.51e-18 Extrinsic epigenetic age acceleration; CESC cis rs412050 0.696 rs56226933 chr22:22339901 C/T cg17089214 chr22:22089827 YPEL1 0.62 5.14 0.3 5.34e-7 Attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00437134 chr2:198364743 HSPE1;HSPD1 0.56 6.65 0.38 1.68e-10 Gut microbiome composition (summer); CESC cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg10556349 chr10:835070 NA 0.53 5.71 0.33 2.99e-8 Eosinophil percentage of granulocytes; CESC cis rs911555 0.546 rs28798508 chr14:104068970 T/C cg24130564 chr14:104152367 KLC1 -0.79 -12.75 -0.62 2.33e-29 Intelligence (multi-trait analysis); CESC cis rs9948 0.655 rs17119591 chr2:97435557 G/A cg01990225 chr2:97406019 LMAN2L -0.98 -7.37 -0.41 2.17e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs7762018 0.943 rs7772889 chr6:170142458 T/C cg05834625 chr6:170176447 C6orf70 0.65 7.37 0.41 2.19e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs372883 0.613 rs1153274 chr21:30660026 T/C cg24692254 chr21:30365293 RNF160 -0.54 -6.95 -0.39 2.89e-11 Pancreatic cancer; CESC cis rs7089973 0.604 rs8181444 chr10:116588981 C/T cg25233709 chr10:116636983 FAM160B1 0.38 5.9 0.34 1.12e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs524281 0.773 rs10896105 chr11:66002260 A/G cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.38e-7 Electroencephalogram traits; CESC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2635047 0.542 rs2668772 chr18:44770621 T/G cg24371990 chr18:44770781 NA 0.35 5.75 0.33 2.5e-8 Educational attainment; CESC cis rs7123876 0.830 rs57614870 chr11:72435983 A/G cg03713592 chr11:72463424 ARAP1 0.6 6.77 0.38 8.21e-11 Body mass index; CESC cis rs9300255 0.679 rs10772998 chr12:123721177 T/G cg00376283 chr12:123451042 ABCB9 0.72 8.81 0.48 1.66e-16 Neutrophil percentage of white cells; CESC cis rs7116495 0.786 rs1894003 chr11:71750276 A/G cg10381502 chr11:71823885 C11orf51 -0.66 -5.46 -0.32 1.08e-7 Severe influenza A (H1N1) infection; CESC cis rs9910055 0.529 rs170637 chr17:42186868 C/T cg19774624 chr17:42201019 HDAC5 0.63 8.89 0.48 9.54e-17 Total body bone mineral density; CESC cis rs3892630 0.824 rs12327732 chr19:33221767 C/T cg13157960 chr19:33183277 NUDT19 0.54 5.09 0.3 6.83e-7 Red blood cell traits; CESC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg17724175 chr1:150552817 MCL1 0.43 6.53 0.37 3.35e-10 Melanoma; CESC cis rs7795096 0.743 rs9648726 chr7:151537433 C/T cg17008978 chr7:151542804 PRKAG2 0.39 7.37 0.41 2.2e-12 Bipolar disorder (age of onset and psychotic symptoms); CESC cis rs8070624 0.574 rs11078408 chr17:17876011 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.68 9.67 0.51 3.79e-19 Total body bone mineral density; CESC cis rs10865397 0.506 rs13414160 chr2:73383261 C/A cg01422370 chr2:73384389 NA 0.46 7.27 0.41 4.11e-12 Intelligence (multi-trait analysis); CESC cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg15556689 chr8:8085844 FLJ10661 0.58 6.95 0.39 2.88e-11 Mood instability; CESC cis rs7264396 1.000 rs6088881 chr20:34165609 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.57 7.05 0.4 1.52e-11 Total cholesterol levels; CESC cis rs1559088 1.000 rs7245404 chr19:33550589 C/T cg17764715 chr19:33622953 WDR88 0.45 5.67 0.33 3.76e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4925325 0.876 rs6089560 chr20:60517325 T/G cg23262073 chr20:60523788 NA -0.57 -7.92 -0.44 6.63e-14 Obesity-related traits; CESC cis rs16917546 1.000 rs10995255 chr10:64402433 G/A cg03961010 chr10:64397487 ZNF365 -0.37 -6.11 -0.35 3.47e-9 Basal cell carcinoma; CESC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.64 0.47 5.23e-16 Menopause (age at onset); CESC cis rs8072100 0.713 rs11651643 chr17:45483229 A/G cg08085267 chr17:45401833 C17orf57 -0.52 -6.64 -0.38 1.81e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs977987 0.624 rs59867374 chr16:75432682 G/A cg03315344 chr16:75512273 CHST6 0.4 5.74 0.33 2.61e-8 Dupuytren's disease; CESC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.79 9.65 0.51 4.49e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs2832191 0.703 rs2853827 chr21:30443596 T/C cg08807101 chr21:30365312 RNF160 0.95 14.3 0.66 8.82e-35 Dental caries; CESC cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg05347473 chr6:146136440 FBXO30 0.58 7.33 0.41 2.84e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs16867321 0.950 rs1919152 chr2:181507765 C/T cg23363182 chr2:181467187 NA -0.44 -5.7 -0.33 3.17e-8 Obesity; CESC cis rs6912958 0.781 rs7757636 chr6:88256092 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -5.93 -0.34 9.52e-9 Monocyte percentage of white cells; CESC cis rs6430585 0.583 rs4988163 chr2:136628121 G/T cg07169764 chr2:136633963 MCM6 1.17 17.57 0.73 2.34e-46 Corneal structure; CESC cis rs35110281 0.744 rs230645 chr21:44918607 A/G cg01579765 chr21:45077557 HSF2BP 0.51 8.74 0.47 2.77e-16 Mean corpuscular volume; CESC cis rs365132 0.875 rs2456178 chr5:176413570 C/G cg16309518 chr5:176445507 NA -0.37 -5.35 -0.31 1.9e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg01448562 chr3:133502909 NA -0.43 -6.11 -0.35 3.59e-9 Iron status biomarkers; CESC cis rs6912958 1.000 rs6912958 chr6:88133315 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.66 -9.08 -0.49 2.62e-17 Monocyte percentage of white cells; CESC cis rs1707322 1.000 rs7553924 chr1:46352624 T/C cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2573652 0.722 rs12903458 chr15:100542673 T/G cg00587665 chr15:100533223 ADAMTS17 -0.42 -6.74 -0.38 9.83e-11 Height; CESC cis rs1976403 0.633 rs1697422 chr1:21821897 T/C cg02390115 chr1:21767211 NBPF3 0.36 5.2 0.3 4.08e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg09263875 chr16:632152 PIGQ 0.66 11.22 0.57 3.6e-24 Height; CESC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg07747251 chr5:1868357 NA 0.33 5.38 0.31 1.6e-7 Cardiovascular disease risk factors; CESC cis rs6912958 0.631 rs9450704 chr6:88182704 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.45 -6.01 -0.35 6.24e-9 Monocyte percentage of white cells; CESC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg08470875 chr2:26401718 FAM59B 0.7 7.01 0.4 2.02e-11 Gut microbiome composition (summer); CESC cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg24112000 chr20:60950667 NA 0.44 5.34 0.31 2.03e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg25985355 chr7:65971099 NA -0.31 -5.09 -0.3 6.79e-7 Aortic root size; CESC cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.29 -0.31 2.51e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs9929218 0.954 rs1981871 chr16:68819007 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -8.5 -0.46 1.44e-15 Colorectal cancer; CESC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg08859206 chr1:53392774 SCP2 -0.59 -7.59 -0.42 5.48e-13 Monocyte count; CESC cis rs10256972 0.869 rs13236369 chr7:1033799 G/T cg07308232 chr7:1071921 C7orf50 -0.42 -5.67 -0.33 3.76e-8 Longevity;Endometriosis; CESC cis rs9303401 0.614 rs8081058 chr17:57160513 G/C cg12560992 chr17:57184187 TRIM37 0.5 5.21 0.3 3.78e-7 Cognitive test performance; CESC cis rs2243480 1.000 rs34529418 chr7:65403209 A/G cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg11644478 chr21:40555479 PSMG1 1.04 16.79 0.72 1.35e-43 Cognitive function; CESC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg09323728 chr8:95962352 TP53INP1 -0.4 -8.76 -0.47 2.34e-16 Type 2 diabetes; CESC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg14393609 chr7:65229607 NA 0.45 6.3 0.36 1.23e-9 Calcium levels; CESC cis rs826838 0.935 rs1486357 chr12:39073675 A/G cg13010199 chr12:38710504 ALG10B 0.57 7.91 0.44 7.22e-14 Heart rate; CESC cis rs7296418 0.961 rs1790094 chr12:123586688 T/C cg05973401 chr12:123451056 ABCB9 0.57 7.44 0.42 1.43e-12 Platelet count; CESC cis rs4253311 0.520 rs10000459 chr4:187124459 A/C cg24794857 chr4:187113578 CYP4V2 0.49 6.65 0.38 1.62e-10 Plasma renin activity levels;Circulating chromogranin peptide levels;Blood metabolite levels; CESC cis rs4689592 0.503 rs56099074 chr4:7071259 A/G cg26116260 chr4:7069785 GRPEL1 -0.87 -9.58 -0.51 7.17e-19 Monocyte percentage of white cells; CESC cis rs7666738 0.546 rs17546687 chr4:98769266 T/A cg05340658 chr4:99064831 C4orf37 0.53 6.42 0.37 6.12e-10 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg27170947 chr2:26402098 FAM59B -0.77 -8.46 -0.46 1.78e-15 Gut microbiome composition (summer); CESC cis rs9611565 0.765 rs132907 chr22:41801268 A/C cg06481639 chr22:41940642 POLR3H 0.64 6.56 0.37 2.82e-10 Vitiligo; CESC cis rs76419734 0.558 rs4235415 chr4:106593850 A/G cg24545054 chr4:106630052 GSTCD;INTS12 0.77 10.0 0.52 3.46e-20 Post bronchodilator FEV1; CESC cis rs9393777 0.920 rs13191227 chr6:27390115 G/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 5.45 0.32 1.15e-7 Intelligence (multi-trait analysis); CESC cis rs7631605 0.870 rs11129746 chr3:37001972 C/G cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.31 -0.31 2.32e-7 Cerebrospinal P-tau181p levels; CESC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 10.35 0.54 2.55e-21 Platelet count; CESC cis rs8092503 1.000 rs3764516 chr18:52494374 A/C cg12377874 chr18:52495404 RAB27B -0.33 -5.75 -0.33 2.4e-8 Childhood body mass index; CESC trans rs7577696 0.962 rs13022197 chr2:32343167 A/T cg12174077 chr18:77897878 ADNP2 0.37 6.17 0.35 2.48e-9 Inflammatory biomarkers; CESC cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg22862634 chr11:62369728 EML3;MTA2 0.48 6.44 0.37 5.69e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs854765 0.686 rs8065497 chr17:17782649 A/G cg16928487 chr17:17741425 SREBF1 0.57 9.44 0.5 2.01e-18 Total body bone mineral density; CESC cis rs1729951 0.575 rs1682357 chr3:136692009 G/A cg25687071 chr3:136751404 NA 0.4 5.21 0.3 3.75e-7 Neuroticism; CESC trans rs11039798 0.512 rs11040205 chr11:49007360 G/C cg15704280 chr7:45808275 SEPT13 0.65 6.62 0.38 1.93e-10 Axial length; CESC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg24531977 chr5:56204891 C5orf35 -0.44 -5.57 -0.32 6.3e-8 Coronary artery disease; CESC cis rs2204008 0.811 rs4882300 chr12:38415224 A/T cg13010199 chr12:38710504 ALG10B -0.42 -5.47 -0.32 1.03e-7 Bladder cancer; CESC cis rs897080 0.553 rs1067338 chr2:44624708 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.8 0.34 1.88e-8 Height; CESC cis rs17608059 0.545 rs9915045 chr17:13902636 G/T cg11395062 chr17:14139857 CDRT15 0.46 5.69 0.33 3.3e-8 Temperament; CESC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg11764359 chr7:65958608 NA -0.92 -14.53 -0.67 1.44e-35 Aortic root size; CESC cis rs6582630 0.503 rs4882293 chr12:38388200 G/C cg26384229 chr12:38710491 ALG10B -0.47 -6.27 -0.36 1.45e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg02574844 chr11:5959923 NA 0.48 6.8 0.39 6.81e-11 DNA methylation (variation); CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg05564831 chr3:52568323 NT5DC2 0.47 8.04 0.44 2.96e-14 Bipolar disorder; CESC cis rs9916302 0.904 rs6503503 chr17:37514373 G/A cg00129232 chr17:37814104 STARD3 0.52 6.49 0.37 4.13e-10 Glomerular filtration rate (creatinine); CESC cis rs1707322 0.963 rs9787412 chr1:46371596 C/T cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs208520 1.000 rs12193077 chr6:66989548 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 9.4 0.5 2.73e-18 Exhaled nitric oxide output; CESC cis rs4141404 0.561 rs5994376 chr22:31563555 A/C cg02404636 chr22:31891804 SFI1 -0.37 -5.17 -0.3 4.66e-7 Paclitaxel-induced neuropathy; CESC cis rs7123876 0.830 rs57614870 chr11:72435983 A/G cg04827223 chr11:72435913 ARAP1 -0.84 -15.39 -0.69 1.27e-38 Body mass index; CESC cis rs12048904 0.964 rs8888 chr1:101338324 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.57 7.51 0.42 8.93e-13 Multiple sclerosis; CESC cis rs4253772 0.550 rs6008762 chr22:46736228 T/C cg00784671 chr22:46762841 CELSR1 -0.48 -5.36 -0.31 1.85e-7 LDL cholesterol;Cholesterol, total; CESC trans rs9388451 0.807 rs1269175 chr6:126040435 A/G cg05039488 chr6:79577232 IRAK1BP1 0.52 6.79 0.38 7.55e-11 Brugada syndrome; CESC cis rs9457247 0.967 rs428805 chr6:167403132 C/A cg23791538 chr6:167370224 RNASET2 -0.59 -8.32 -0.46 4.54e-15 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18902057 chr16:88636444 ZC3H18 -0.59 -6.81 -0.39 6.63e-11 Gut microbiome composition (summer); CESC cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg06484146 chr7:12443880 VWDE -0.79 -9.25 -0.49 7.67e-18 Coronary artery disease; CESC cis rs1670533 1.000 rs10026482 chr4:1051128 C/G cg27284194 chr4:1044797 NA 0.45 5.54 0.32 7.32e-8 Recombination rate (females); CESC cis rs73001065 0.551 rs10424702 chr19:19508013 A/G cg03709012 chr19:19516395 GATAD2A 0.9 7.63 0.42 4.28e-13 LDL cholesterol; CESC cis rs9399135 0.935 rs987690 chr6:135350379 A/G cg22676075 chr6:135203613 NA 0.51 7.36 0.41 2.34e-12 Red blood cell count; CESC cis rs7520050 0.831 rs61783170 chr1:46256329 T/C cg24296786 chr1:45957014 TESK2 0.41 5.08 0.3 7.28e-7 Red blood cell count;Reticulocyte count; CESC cis rs9549260 0.564 rs9549271 chr13:41295477 T/C cg21288729 chr13:41239152 FOXO1 0.57 7.17 0.4 7.44e-12 Red blood cell count; CESC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg13206674 chr6:150067644 NUP43 0.45 6.53 0.37 3.38e-10 Lung cancer; CESC cis rs7599312 1.000 rs7599312 chr2:213413231 C/T cg16329650 chr2:213403929 ERBB4 0.42 5.06 0.3 7.88e-7 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2479106 0.591 rs7855329 chr9:126352551 A/G cg16191174 chr9:126692580 DENND1A 0.38 5.19 0.3 4.25e-7 Polycystic ovary syndrome; CESC cis rs7089973 0.604 rs17095662 chr10:116596071 A/C cg25233709 chr10:116636983 FAM160B1 0.38 6.02 0.35 5.79e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7188697 0.775 rs8056620 chr16:58604387 T/A cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC cis rs9399135 0.967 rs4895439 chr6:135318854 A/T cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14308291 chr1:36396265 EIF2C3 -0.64 -7.42 -0.41 1.59e-12 Gut microbiome composition (summer); CESC cis rs7829975 0.511 rs2921028 chr8:8340477 T/C cg15556689 chr8:8085844 FLJ10661 0.53 6.58 0.37 2.58e-10 Mood instability; CESC cis rs763014 0.898 rs2017567 chr16:637212 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.15 -0.3 5.13e-7 Height; CESC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.37 -6.03 -0.35 5.46e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs3087591 0.960 rs9807077 chr17:29634457 A/G cg24425628 chr17:29625626 OMG;NF1 -0.41 -5.05 -0.3 8.18e-7 Hip circumference; CESC cis rs9467711 0.659 rs35680819 chr6:26455814 T/C cg14345882 chr6:26364793 BTN3A2 0.64 5.28 0.31 2.67e-7 Autism spectrum disorder or schizophrenia; CESC cis rs3806843 0.966 rs7737424 chr5:140146345 C/T cg26395211 chr5:140044315 WDR55 -0.39 -5.12 -0.3 5.97e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7267979 0.866 rs6138609 chr20:25570985 T/A cg24626310 chr20:25276739 ABHD12;PYGB 0.73 12.77 0.62 1.93e-29 Liver enzyme levels (alkaline phosphatase); CESC cis rs10781543 0.810 rs11145756 chr9:139364585 A/G cg14169450 chr9:139327907 INPP5E 0.5 7.88 0.44 8.58e-14 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24514954 chr1:24104624 C1orf128 0.61 6.38 0.36 7.91e-10 Gut microbiome composition (summer); CESC cis rs1707322 0.721 rs4609469 chr1:46117185 C/T cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg17971929 chr21:40555470 PSMG1 1.07 16.65 0.72 4.28e-43 Cognitive function; CESC cis rs9911578 0.741 rs2611776 chr17:56819636 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.21 0.3 3.88e-7 Intelligence (multi-trait analysis); CESC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg23161317 chr6:28129485 ZNF389 0.46 6.0 0.35 6.62e-9 Depression; CESC cis rs3806843 0.966 rs2337516 chr5:140140853 A/G cg26395211 chr5:140044315 WDR55 0.4 5.08 0.3 7.22e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -9.15 -0.49 1.55e-17 Personality dimensions; CESC cis rs61612642 0.523 rs59004693 chr6:42157392 G/A cg01092361 chr6:42185687 MRPS10 0.82 7.95 0.44 5.41e-14 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs10733682 1.000 rs10733682 chr9:129460914 C/T cg00232160 chr9:129468157 NA 0.33 5.2 0.3 3.97e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs35110281 0.548 rs2838350 chr21:45109972 T/C cg21573476 chr21:45109991 RRP1B -0.61 -8.84 -0.48 1.4e-16 Mean corpuscular volume; CESC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg21724239 chr8:58056113 NA 0.6 5.46 0.32 1.1e-7 Developmental language disorder (linguistic errors); CESC trans rs10832139 0.553 rs1395847 chr11:13931722 T/C cg11511669 chr12:131556214 GPR133 -0.48 -6.06 -0.35 4.76e-9 P wave terminal force; CESC cis rs36051895 0.623 rs6476957 chr9:5261324 A/G cg02405213 chr9:5042618 JAK2 -0.52 -6.43 -0.37 5.85e-10 Pediatric autoimmune diseases; CESC cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 10.02 0.52 2.95e-20 Platelet count; CESC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg15445000 chr17:37608096 MED1 0.41 6.83 0.39 5.8200000000000003e-11 Glomerular filtration rate (creatinine); CESC cis rs1577917 1.000 rs12213149 chr6:86668644 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.08 -0.35 4.29e-9 Response to antipsychotic treatment; CESC cis rs79349575 0.749 rs12601672 chr17:47006493 T/C cg16584676 chr17:46985605 UBE2Z 0.53 6.54 0.37 3.16e-10 Type 2 diabetes; CESC cis rs10463316 0.832 rs246483 chr5:150731062 C/G cg03212797 chr5:150827313 SLC36A1 -0.52 -6.73 -0.38 1.06e-10 Metabolite levels (Pyroglutamine); CESC cis rs684232 0.644 rs2543781 chr17:602469 C/G cg15660573 chr17:549704 VPS53 -0.64 -8.93 -0.48 7.06e-17 Prostate cancer; CESC trans rs11039798 0.565 rs7118675 chr11:48532063 C/A cg15704280 chr7:45808275 SEPT13 0.66 6.68 0.38 1.4e-10 Axial length; CESC cis rs7560272 0.538 rs13000788 chr2:73918312 C/T cg20560298 chr2:73613845 ALMS1 0.45 6.29 0.36 1.31e-9 Schizophrenia; CESC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg08859206 chr1:53392774 SCP2 -0.58 -7.73 -0.43 2.26e-13 Monocyte count; CESC trans rs9325144 0.647 rs7980932 chr12:38921583 G/T cg23762105 chr12:34175262 ALG10 0.46 6.08 0.35 4.08e-9 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10359931 chr4:3519599 LRPAP1 -0.59 -6.25 -0.36 1.6e-9 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs28418643 chr5:240859 A/G cg10591111 chr5:226296 SDHA -0.52 -6.32 -0.36 1.1e-9 Breast cancer; CESC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg01416388 chr22:39784598 NA -0.57 -6.95 -0.39 2.87e-11 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg11494091 chr17:61959527 GH2 0.72 12.48 0.61 1.93e-28 Prudent dietary pattern; CESC cis rs1048238 0.506 rs7547314 chr1:16186722 G/A cg22431228 chr1:16359049 CLCNKA -0.36 -6.44 -0.37 5.62e-10 Systolic blood pressure; CESC cis rs7845219 0.544 rs9643352 chr8:95918288 C/T cg23172400 chr8:95962367 TP53INP1 -0.37 -6.78 -0.38 7.89e-11 Type 2 diabetes; CESC cis rs9894429 0.789 rs7213849 chr17:79567610 C/T cg21984481 chr17:79567631 NPLOC4 0.57 9.27 0.49 6.66e-18 Eye color traits; CESC cis rs7980687 0.574 rs10744149 chr12:123708490 T/A cg19016782 chr12:123741754 C12orf65 -0.42 -6.03 -0.35 5.35e-9 Height;Educational attainment;Head circumference (infant); CESC cis rs1371867 0.846 rs924057 chr8:101266157 A/G cg11906718 chr8:101322791 RNF19A -0.42 -5.45 -0.32 1.17e-7 Atrioventricular conduction; CESC trans rs8073060 0.586 rs7208672 chr17:33989759 G/A cg19694781 chr19:47549865 TMEM160 -0.75 -7.05 -0.4 1.53e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs1865760 0.566 rs1539183 chr6:26075051 G/C cg17691542 chr6:26056736 HIST1H1C 0.42 5.66 0.33 3.97e-8 Height; CESC cis rs10992471 0.756 rs10123342 chr9:95087824 T/G cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -5.63 -0.33 4.56e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC trans rs9325144 0.600 rs6582634 chr12:38748041 G/A cg23762105 chr12:34175262 ALG10 -0.47 -6.33 -0.36 1.05e-9 Morning vs. evening chronotype; CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg09177884 chr7:1199841 ZFAND2A -0.68 -9.34 -0.5 4.24e-18 Longevity;Endometriosis; CESC cis rs12586317 0.547 rs78609489 chr14:35497285 T/C cg05294307 chr14:35346193 BAZ1A -0.55 -5.61 -0.33 4.97e-8 Psoriasis; CESC cis rs3820068 0.532 rs72647105 chr1:15935238 C/G cg13390004 chr1:15929781 NA 0.37 5.96 0.34 8.08e-9 Systolic blood pressure; CESC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg09699651 chr6:150184138 LRP11 0.44 5.63 0.33 4.66e-8 Lung cancer; CESC cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg10295955 chr4:187884368 NA -1.09 -22.92 -0.82 7.71e-65 Lobe attachment (rater-scored or self-reported); CESC cis rs7551222 0.752 rs10900596 chr1:204522457 T/C cg20240347 chr1:204465584 NA -0.28 -5.6 -0.33 5.23e-8 Schizophrenia; CESC trans rs17514846 0.565 rs2521498 chr15:91442152 A/T cg10493739 chr9:108456981 TMEM38B 0.44 6.27 0.36 1.49e-9 Coronary artery disease; CESC cis rs9487051 0.597 rs59673 chr6:109548713 C/T cg01475377 chr6:109611718 NA -0.4 -5.33 -0.31 2.12e-7 Reticulocyte fraction of red cells; CESC cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg17775713 chr3:133465469 TF 0.35 6.26 0.36 1.52e-9 Iron status biomarkers (transferrin levels); CESC cis rs9303401 0.659 rs12602808 chr17:56698420 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.04 13.0 0.62 3.27e-30 Cognitive test performance; CESC cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.42 6.74 0.38 1.01e-10 Personality dimensions; CESC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.26 -0.36 1.54e-9 Total body bone mineral density; CESC cis rs6543140 0.964 rs13393175 chr2:103078849 T/G cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs367943 0.698 rs2115208 chr5:112973994 A/G cg12552261 chr5:112820674 MCC 0.43 5.48 0.32 9.97e-8 Type 2 diabetes; CESC trans rs11098499 0.821 rs3775852 chr4:120454556 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.47e-19 Corneal astigmatism; CESC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg06221963 chr1:154839813 KCNN3 -0.56 -8.87 -0.48 1.13e-16 Prostate cancer; CESC cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg23649088 chr2:200775458 C2orf69 0.56 5.29 0.31 2.59e-7 Schizophrenia; CESC cis rs709400 0.663 rs62007687 chr14:103903763 G/T cg12935359 chr14:103987150 CKB -0.56 -8.16 -0.45 1.36e-14 Body mass index; CESC cis rs7937682 1.000 rs11213980 chr11:111562692 A/T cg09085632 chr11:111637200 PPP2R1B 0.92 12.55 0.61 1.17e-28 Primary sclerosing cholangitis; CESC cis rs9287719 0.967 rs6744854 chr2:10747246 C/G cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs4595586 0.545 rs12815047 chr12:39380901 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs12618769 0.597 rs4850875 chr2:99069815 A/G cg10123293 chr2:99228465 UNC50 0.39 5.22 0.31 3.7e-7 Bipolar disorder; CESC cis rs7662987 0.517 rs3018048 chr4:100005538 C/T cg13256891 chr4:100009986 ADH5 0.75 8.32 0.46 4.75e-15 Smoking initiation; CESC cis rs7481584 0.624 rs511990 chr11:3052936 A/G cg25174290 chr11:3078921 CARS -0.45 -6.34 -0.36 9.61e-10 Calcium levels; CESC cis rs4523957 0.533 rs170043 chr17:2200434 G/T cg16513277 chr17:2031491 SMG6 -0.52 -5.36 -0.31 1.78e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.58 5.38 0.31 1.63e-7 Lung function (FEV1/FVC); CESC cis rs1878931 0.501 rs9635563 chr16:3416940 A/G cg05754148 chr16:3507555 NAT15 -0.39 -5.19 -0.3 4.24e-7 Body mass index (adult); CESC cis rs6690583 0.623 rs61770879 chr1:85504938 A/C cg22153463 chr1:85462885 MCOLN2 0.78 7.43 0.42 1.49e-12 Serum sulfate level; CESC cis rs4589502 0.841 rs56401320 chr15:67140517 C/G cg12317470 chr15:67143691 NA 0.75 6.84 0.39 5.53e-11 Lung cancer (smoking interaction); CESC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg18350739 chr11:68623251 NA -0.46 -7.19 -0.4 6.69e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13031619 0.517 rs10183413 chr2:3684342 T/C cg19052272 chr2:3704530 ALLC 0.44 5.12 0.3 5.89e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs9948 1.000 rs72811623 chr2:97496473 C/T cg01990225 chr2:97406019 LMAN2L -0.75 -5.42 -0.32 1.35e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs6582630 0.555 rs35284307 chr12:38509999 T/G cg13010199 chr12:38710504 ALG10B 0.46 5.91 0.34 1.03e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01136232 chr1:25756842 TMEM57 -0.55 -6.13 -0.35 3.12e-9 Gut microbiome composition (summer); CESC cis rs11168351 0.926 rs10875719 chr12:48411158 T/C cg04545296 chr12:48745243 ZNF641 0.34 5.89 0.34 1.17e-8 Bipolar disorder and schizophrenia; CESC cis rs9796 0.621 rs7170049 chr15:41484287 C/A cg18705301 chr15:41695430 NDUFAF1 -0.44 -6.47 -0.37 4.69e-10 Menopause (age at onset); CESC cis rs698833 0.926 rs1067406 chr2:44674450 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.8 0.34 1.9e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23181591 chr8:123793873 ZHX2 0.52 6.78 0.38 7.62e-11 Gut microbiota (bacterial taxa); CESC cis rs11098499 0.865 rs28753180 chr4:120405367 A/T cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.1e-8 Corneal astigmatism; CESC cis rs6121246 0.559 rs6060962 chr20:30397847 A/G cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs9399135 0.967 rs9376085 chr6:135371224 T/C cg24558204 chr6:135376177 HBS1L 0.49 6.77 0.38 8.11e-11 Red blood cell count; CESC cis rs9595066 1.000 rs7981575 chr13:44710947 C/T cg04068111 chr13:44716778 NA -0.52 -6.73 -0.38 1.02e-10 Schizophrenia; CESC cis rs826838 0.802 rs10785619 chr12:38742897 T/A cg13010199 chr12:38710504 ALG10B 0.43 6.21 0.36 2.06e-9 Heart rate; CESC cis rs6733011 0.502 rs6542847 chr2:99573471 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -5.18 -0.3 4.48e-7 Bipolar disorder; CESC cis rs7312933 0.566 rs11181454 chr12:42746486 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.5 -6.62 -0.38 2e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs8005677 0.962 rs8003934 chr14:23401142 A/G cg01529538 chr14:23388837 RBM23 0.5 6.72 0.38 1.14e-10 Cognitive ability (multi-trait analysis); CESC cis rs2569991 0.636 rs9211 chr3:12939546 A/G cg22481960 chr3:13008800 IQSEC1 0.5 6.09 0.35 3.88e-9 Periodontitis (DPAL); CESC cis rs9796 0.717 rs476633 chr15:41392134 C/G cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.28 -0.36 1.4e-9 Menopause (age at onset); CESC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg26335602 chr6:28129616 ZNF389 0.38 5.52 0.32 7.89e-8 Cardiac Troponin-T levels; CESC cis rs1153858 1.000 rs7163720 chr15:45639374 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC trans rs3896439 1.000 rs12141994 chr1:4667996 C/G cg11038280 chr7:92466132 CDK6 -0.71 -6.11 -0.35 3.61e-9 Dental caries; CESC cis rs6867032 0.687 rs4998338 chr5:2015910 A/G cg26168224 chr5:2018326 NA 0.96 19.64 0.77 1.3e-53 Gut microbiome composition (winter); CESC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC cis rs3740540 0.507 rs897293 chr10:126290050 T/G cg04949429 chr10:126290192 LHPP 0.38 5.36 0.31 1.77e-7 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.15 0.3 5.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 1.000 rs4815407 chr20:25341478 G/C cg08601574 chr20:25228251 PYGB -0.38 -5.41 -0.32 1.44e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs56873913 0.904 rs3760708 chr19:50084596 G/C cg09250473 chr19:50168907 IRF3;BCL2L12 0.45 5.18 0.3 4.38e-7 Schizophrenia; CESC cis rs8062405 0.755 rs4787455 chr16:28589455 G/A cg01378222 chr16:28622494 SULT1A1 0.3 5.06 0.3 7.89e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs10463316 0.928 rs4958451 chr5:150740007 T/C cg03212797 chr5:150827313 SLC36A1 -0.53 -6.75 -0.38 9.04e-11 Metabolite levels (Pyroglutamine); CESC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg04317338 chr11:64019027 PLCB3 0.9 9.39 0.5 2.86e-18 Mean platelet volume; CESC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg13395646 chr4:1353034 KIAA1530 -0.53 -6.58 -0.37 2.48e-10 Obesity-related traits; CESC cis rs16866061 1.000 rs72974238 chr2:225432470 C/A cg12698349 chr2:225449008 CUL3 0.76 11.32 0.57 1.67e-24 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs3733585 0.673 rs4235348 chr4:9951968 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20544562 chr6:12012554 HIVEP1 -0.58 -6.57 -0.37 2.63e-10 Gut microbiome composition (summer); CESC cis rs2295499 0.649 rs55679022 chr4:2707325 T/G cg27239842 chr4:2403781 ZFYVE28 -0.34 -5.82 -0.34 1.69e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg18032046 chr6:28092343 ZSCAN16 -0.59 -7.05 -0.4 1.58e-11 Parkinson's disease; CESC cis rs12142240 0.659 rs111723629 chr1:46853361 G/T cg10495392 chr1:46806563 NSUN4 0.56 6.15 0.35 2.86e-9 Menopause (age at onset); CESC cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.83 8.86 0.48 1.15e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs7922314 0.571 rs16917991 chr10:64737762 A/C cg06935979 chr1:232941706 KIAA1383 -0.63 -6.09 -0.35 3.89e-9 Cutaneous psoriasis; CESC cis rs3540 0.618 rs11636089 chr15:91039527 C/T cg10434728 chr15:90938212 IQGAP1 0.43 7.76 0.43 1.89e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg08736216 chr1:53307985 ZYG11A -0.41 -7.04 -0.4 1.66e-11 Monocyte count; CESC cis rs3768617 0.510 rs10797843 chr1:183081995 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 14.13 0.66 3.47e-34 Fuchs's corneal dystrophy; CESC cis rs2120019 0.935 rs8043181 chr15:75380424 T/C cg17294928 chr15:75287854 SCAMP5 -0.61 -6.84 -0.39 5.52e-11 Blood trace element (Zn levels); CESC cis rs11723261 0.564 rs60994255 chr4:77446 G/A cg12746427 chr4:53362 ZNF718;ZNF595 0.51 6.04 0.35 5.32e-9 Immune response to smallpox vaccine (IL-6); CESC cis rs4253772 0.530 rs11704350 chr22:46671507 C/T cg00784671 chr22:46762841 CELSR1 -0.57 -5.81 -0.34 1.75e-8 LDL cholesterol;Cholesterol, total; CESC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg12648201 chr2:27665141 KRTCAP3 -0.3 -5.4 -0.31 1.48e-7 Total body bone mineral density; CESC cis rs7980687 0.550 rs1727324 chr12:123698603 A/T cg00376283 chr12:123451042 ABCB9 0.61 6.34 0.36 9.86e-10 Height;Educational attainment;Head circumference (infant); CESC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg01097406 chr16:89675127 NA 0.38 5.33 0.31 2.09e-7 Vitiligo; CESC cis rs763121 0.853 rs2284073 chr22:39105948 T/C cg21395723 chr22:39101663 GTPBP1 0.5 6.84 0.39 5.32e-11 Menopause (age at onset); CESC cis rs4865169 0.967 rs10023088 chr4:57884435 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.36 5.05 0.3 8.34e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26085966 chr14:64319812 SYNE2 0.58 6.12 0.35 3.36e-9 Gut microbiome composition (summer); CESC cis rs35079168 0.923 rs10858277 chr9:137287959 G/A cg00753924 chr9:137298813 RXRA -0.36 -5.56 -0.32 6.58e-8 Intelligence; CESC cis rs11252926 0.583 rs4881333 chr10:519164 G/C cg18196295 chr10:418757 DIP2C 0.4 5.4 0.32 1.46e-7 Psychosis in Alzheimer's disease; CESC trans rs1493916 0.967 rs34341086 chr18:31400141 C/T cg27147174 chr7:100797783 AP1S1 -0.54 -7.29 -0.41 3.53e-12 Life satisfaction; CESC cis rs9916302 0.653 rs11654954 chr17:37745979 C/T cg07936489 chr17:37558343 FBXL20 0.9 9.11 0.49 2.13e-17 Glomerular filtration rate (creatinine); CESC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg05368731 chr17:41323189 NBR1 0.77 10.58 0.54 4.75e-22 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19318450 chr21:34852305 TMEM50B 0.57 6.35 0.36 9.52e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08754618 chr20:24973613 C20orf3 0.57 6.33 0.36 1.01e-9 Gut microbiome composition (summer); CESC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg27266027 chr21:40555129 PSMG1 0.45 5.46 0.32 1.11e-7 Cognitive function; CESC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.62 7.88 0.44 8.25e-14 Tonsillectomy; CESC cis rs6088580 0.524 rs6088567 chr20:33263872 A/T cg08999081 chr20:33150536 PIGU -0.45 -6.29 -0.36 1.33e-9 Glomerular filtration rate (creatinine); CESC cis rs477692 1.000 rs522891 chr10:131430916 T/C cg05714579 chr10:131428358 MGMT -0.51 -6.94 -0.39 2.93e-11 Response to temozolomide; CESC cis rs5758511 0.514 rs3985938 chr22:42511727 G/T cg00645731 chr22:42541494 CYP2D7P1 0.63 9.78 0.52 1.69e-19 Birth weight; CESC cis rs459482 0.534 rs458255 chr21:42801128 G/A cg14166395 chr21:42792516 MX1 0.45 5.27 0.31 2.84e-7 IgG glycosylation; CESC cis rs6963495 0.538 rs55967123 chr7:105163678 C/A cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs6594499 0.872 rs6865932 chr5:110436852 G/C cg04022379 chr5:110408740 TSLP 0.34 6.22 0.36 1.9e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs67311347 1.000 rs9854493 chr3:40423622 T/C cg09455208 chr3:40491958 NA 0.49 8.0 0.44 3.97e-14 Renal cell carcinoma; CESC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg25072359 chr17:41440525 NA 0.44 5.89 0.34 1.16e-8 Menopause (age at onset); CESC cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg23711669 chr6:146136114 FBXO30 -0.97 -14.91 -0.68 6.51e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs36051895 0.659 rs2149555 chr9:5053743 C/T cg02405213 chr9:5042618 JAK2 -0.49 -5.87 -0.34 1.28e-8 Pediatric autoimmune diseases; CESC cis rs6693567 0.565 rs3125808 chr1:150314272 T/C cg09579323 chr1:150459698 TARS2 0.49 6.28 0.36 1.35e-9 Migraine; CESC cis rs9457247 1.000 rs408087 chr6:167398952 C/T cg25258033 chr6:167368657 RNASET2 0.41 6.27 0.36 1.44e-9 Crohn's disease; CESC cis rs7666738 0.606 rs13108868 chr4:99083753 C/T cg17366294 chr4:99064904 C4orf37 0.43 5.77 0.33 2.15e-8 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.627 rs56369437 chr21:44970275 A/G cg21573476 chr21:45109991 RRP1B -0.4 -5.58 -0.32 6.02e-8 Mean corpuscular volume; CESC cis rs7662987 0.517 rs2851268 chr4:100027878 A/G cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.21e-14 Smoking initiation; CESC cis rs858239 0.601 rs929507 chr7:23166664 G/C cg23682824 chr7:23144976 KLHL7 0.54 7.61 0.42 4.95e-13 Cerebrospinal fluid biomarker levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27238079 chr10:33247273 ITGB1 -0.46 -6.46 -0.37 5.12e-10 Fibrinogen levels; CESC cis rs9486719 1.000 rs2472889 chr6:96866803 T/G cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs7937682 0.632 rs11603779 chr11:111781047 A/C cg22437258 chr11:111473054 SIK2 -0.5 -5.6 -0.33 5.39e-8 Primary sclerosing cholangitis; CESC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg08470875 chr2:26401718 FAM59B -0.75 -7.78 -0.43 1.63e-13 Gut microbiome composition (summer); CESC cis rs10871290 0.881 rs3863436 chr16:74468038 T/C cg01733217 chr16:74700730 RFWD3 -0.7 -9.29 -0.5 6.06e-18 Breast cancer; CESC cis rs643506 1.000 rs612345 chr11:111639122 G/A cg09085632 chr11:111637200 PPP2R1B 0.53 6.74 0.38 9.89e-11 Breast cancer; CESC cis rs72945132 0.882 rs947781 chr11:70212755 G/A cg14191688 chr11:70257035 CTTN 0.43 5.37 0.31 1.72e-7 Coronary artery disease; CESC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 12.9 0.62 7.04e-30 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20861091 chr8:144881744 SCRIB -0.56 -6.87 -0.39 4.59e-11 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs734999 0.545 rs4648565 chr1:2570023 A/G cg20673091 chr1:2541236 MMEL1 -0.48 -7.94 -0.44 5.65e-14 Ulcerative colitis; CESC cis rs6968419 0.755 rs4730720 chr7:115895235 C/T cg02561103 chr7:115862891 TES 0.42 5.48 0.32 1e-7 Intraocular pressure; CESC cis rs3793683 0.597 rs12767469 chr10:134587261 C/G cg26818010 chr10:134567672 INPP5A -0.9 -11.01 -0.56 1.89e-23 Migraine; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03823108 chr20:1099106 PSMF1 0.61 6.94 0.39 2.94e-11 Gut microbiome composition (summer); CESC cis rs2290159 0.800 rs11711419 chr3:12667784 A/T cg23032965 chr3:12705835 RAF1 0.54 5.7 0.33 3.12e-8 Cholesterol, total; CESC cis rs9527 0.545 rs12784384 chr10:104957594 G/C cg04362960 chr10:104952993 NT5C2 0.44 5.56 0.32 6.74e-8 Arsenic metabolism; CESC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg19717773 chr7:2847554 GNA12 -0.58 -8.39 -0.46 2.84e-15 Height; CESC cis rs9910055 0.509 rs9916444 chr17:42313512 C/G cg09913183 chr17:42254507 C17orf65;ASB16 0.41 5.12 0.3 5.78e-7 Total body bone mineral density; CESC trans rs11722228 0.521 rs12501336 chr4:10137351 G/A cg26043149 chr18:55253948 FECH 1.01 13.15 0.63 9.28e-31 Gout;Urate levels;Serum uric acid levels; CESC cis rs13253111 0.603 rs28605937 chr8:28099179 A/G cg26534493 chr8:28060551 NA 0.46 7.29 0.41 3.66e-12 Childhood body mass index; CESC cis rs12142240 0.621 rs66828173 chr1:46818166 G/A cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg12262378 chr17:6899522 ALOX12 0.39 6.78 0.38 7.76e-11 Tonsillectomy; CESC trans rs2207136 0.835 rs61687409 chr6:50857520 A/T cg06522515 chr3:184090630 THPO -0.36 -6.24 -0.36 1.69e-9 Myopia; CESC cis rs10823500 0.545 rs7082562 chr10:71945684 A/G cg04118878 chr10:71993077 PPA1 0.45 5.42 0.32 1.35e-7 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19046697 chr5:92915581 FLJ42709 -0.64 -8.02 -0.44 3.32e-14 Gut microbiome composition (summer); CESC cis rs1178968 0.591 rs10440929 chr7:72786770 A/C cg25889504 chr7:72793014 NA 0.49 5.18 0.3 4.46e-7 Triglyceride levels; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg03762994 chr17:6899332 ALOX12 -0.42 -7.45 -0.42 1.31e-12 Tonsillectomy; CESC cis rs7267979 1.000 rs4815409 chr20:25346697 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.07 -0.74 3.95e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs10214930 0.697 rs757396 chr7:27908326 T/C cg05786569 chr7:27702416 HIBADH 0.44 5.23 0.31 3.39e-7 Hypospadias; CESC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg13628971 chr7:2884303 GNA12 0.63 7.93 0.44 6e-14 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14451979 chr2:748557 NA -0.49 -6.39 -0.37 7.28e-10 Gut microbiome composition (summer); CESC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg04369109 chr6:150039330 LATS1 -0.39 -5.34 -0.31 2.01e-7 Lung cancer; CESC cis rs7264396 0.635 rs6058344 chr20:34475038 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.47 0.42 1.16e-12 Total cholesterol levels; CESC cis rs4332037 1.000 rs62442899 chr7:1948454 C/T cg23422044 chr7:1970798 MAD1L1 -0.49 -5.03 -0.3 9.2e-7 Bipolar disorder; CESC cis rs7917772 0.503 rs6584510 chr10:104299868 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.33 0.41 2.81e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1801251 0.896 rs7573208 chr2:233696701 C/A cg25237894 chr2:233734115 C2orf82 -0.37 -6.67 -0.38 1.51e-10 Coronary artery disease; CESC cis rs1707322 0.721 rs6699418 chr1:46100181 G/A cg03146154 chr1:46216737 IPP 0.76 10.71 0.55 1.75e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.5 -6.04 -0.35 5.21e-9 Breast cancer; CESC cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg22903657 chr4:1355424 KIAA1530 0.37 5.1 0.3 6.59e-7 Obesity-related traits; CESC cis rs4803468 1.000 rs2304242 chr19:41944616 G/T cg08639244 chr19:41945921 ATP5SL 0.43 5.33 0.31 2.07e-7 Height; CESC cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg27478167 chr7:817139 HEATR2 -0.47 -5.53 -0.32 7.51e-8 Cerebrospinal P-tau181p levels; CESC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg14893161 chr1:205819251 PM20D1 0.54 8.08 0.44 2.31e-14 Menarche (age at onset); CESC cis rs10242455 0.557 rs77997620 chr7:99070415 G/T cg25640893 chr7:99214727 ZNF498 0.7 5.17 0.3 4.58e-7 Blood metabolite levels; CESC cis rs9457247 0.602 rs9459854 chr6:167465882 C/T cg23791538 chr6:167370224 RNASET2 -0.52 -6.87 -0.39 4.45e-11 Crohn's disease; CESC trans rs8014252 0.667 rs57535767 chr14:70791349 A/G cg03123320 chr1:229394665 NA -0.49 -6.27 -0.36 1.45e-9 Plasma estrone levels in resected estrogen-receptor positive breast cancer; CESC cis rs6500395 1.000 rs1477134 chr16:48706973 G/A cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs950776 0.752 rs7182583 chr15:78899210 G/C cg06917634 chr15:78832804 PSMA4 0.53 6.37 0.36 8.42e-10 Sudden cardiac arrest; CESC cis rs10751667 0.666 rs7950967 chr11:955638 G/A cg06064525 chr11:970664 AP2A2 -0.48 -9.52 -0.5 1.15e-18 Alzheimer's disease (late onset); CESC cis rs611744 0.608 rs1448152 chr8:109278249 C/T cg21045802 chr8:109455806 TTC35 0.5 6.23 0.36 1.82e-9 Dupuytren's disease; CESC cis rs2816062 0.735 rs2816045 chr1:18892999 A/G cg18795169 chr1:18902165 NA -0.92 -18.09 -0.74 3.38e-48 Urate levels in lean individuals; CESC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg03517284 chr6:25882590 NA 0.33 5.23 0.31 3.41e-7 Blood metabolite levels; CESC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg24829409 chr8:58192753 C8orf71 -0.67 -7.47 -0.42 1.15e-12 Developmental language disorder (linguistic errors); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg00353844 chr1:3275283 PRDM16 0.36 6.08 0.35 4.12e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg05564831 chr3:52568323 NT5DC2 0.42 6.09 0.35 3.9e-9 Bipolar disorder; CESC cis rs4699052 0.928 rs2169511 chr4:104192580 G/A cg16532752 chr4:104119610 CENPE -0.43 -5.96 -0.34 8.21e-9 Testicular germ cell tumor; CESC cis rs6582630 0.555 rs7978749 chr12:38527141 G/T cg26384229 chr12:38710491 ALG10B 0.71 10.81 0.55 8.51e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs7833986 0.501 rs72653953 chr8:56970795 C/T cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.18 0.3 4.34e-7 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09964670 chr19:5720572 TMEM146;LONP1 -0.49 -6.37 -0.36 8.33e-10 Ulcerative colitis; CESC cis rs6028335 0.674 rs59096774 chr20:37603529 A/G cg16355469 chr20:37678765 NA 0.52 5.13 0.3 5.5e-7 Alcohol and nicotine co-dependence; CESC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.98 -0.34 7.07e-9 Total body bone mineral density; CESC cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg22467129 chr15:76604101 ETFA 0.39 5.85 0.34 1.47e-8 Blood metabolite levels; CESC cis rs41271951 0.512 rs12058128 chr1:151106113 C/T cg11822372 chr1:151115635 SEMA6C -0.63 -5.06 -0.3 7.96e-7 Blood protein levels; CESC cis rs12602901 0.519 rs238238 chr17:4856376 A/G cg19427746 chr17:4889932 CAMTA2 -0.35 -5.51 -0.32 8.29e-8 Blood metabolite levels; CESC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 10.82 0.55 7.72e-23 Platelet count; CESC cis rs7937682 0.924 rs489783 chr11:111520522 A/G cg09085632 chr11:111637200 PPP2R1B -0.99 -16.01 -0.7 8.36e-41 Primary sclerosing cholangitis; CESC cis rs6964587 0.773 rs17757926 chr7:91987702 T/C cg17063962 chr7:91808500 NA 0.54 6.79 0.38 7.4e-11 Breast cancer; CESC cis rs1005277 0.505 rs7099777 chr10:38183569 A/C cg25427524 chr10:38739819 LOC399744 0.69 10.35 0.54 2.68e-21 Extrinsic epigenetic age acceleration; CESC cis rs2760061 0.655 rs686533 chr1:228119604 A/G cg02753203 chr1:228287806 NA -0.5 -7.36 -0.41 2.27e-12 Diastolic blood pressure; CESC cis rs9911578 0.874 rs302874 chr17:56767996 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.15 0.3 4.99e-7 Intelligence (multi-trait analysis); CESC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg24531977 chr5:56204891 C5orf35 -0.67 -9.26 -0.49 7.22e-18 Initial pursuit acceleration; CESC cis rs6499755 0.712 rs31090 chr16:55363628 A/G cg02859129 chr16:55357253 IRX6 0.32 5.05 0.3 8.04e-7 Hypospadias; CESC cis rs12541635 0.677 rs10808408 chr8:107005034 C/T cg10147462 chr8:107024639 NA 0.42 6.23 0.36 1.83e-9 Age of smoking initiation; CESC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg04248312 chr19:17393744 ANKLE1 -0.93 -15.09 -0.68 1.45e-37 Systemic lupus erythematosus; CESC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg25767906 chr1:53392781 SCP2 -0.44 -5.61 -0.33 4.98e-8 Monocyte count; CESC cis rs17641971 0.684 rs4873094 chr8:49989578 G/T cg00325661 chr8:49890786 NA 0.39 5.5 0.32 8.94e-8 Blood metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08209184 chr20:35444560 C20orf117 0.45 6.42 0.37 6.31e-10 Fibrinogen levels; CESC cis rs3733585 0.699 rs60045583 chr4:9971950 G/A cg11266682 chr4:10021025 SLC2A9 -0.58 -10.83 -0.55 7.08e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs67311347 1.000 rs9332450 chr3:40458041 C/T cg24209194 chr3:40518798 ZNF619 -0.45 -5.86 -0.34 1.39e-8 Renal cell carcinoma; CESC trans rs11191205 0.644 rs12354716 chr10:103386775 C/A cg12418535 chr2:119607192 EN1 -0.4 -6.0 -0.35 6.56e-9 Intelligence (multi-trait analysis); CESC cis rs642803 0.591 rs620088 chr11:65508986 G/A cg08755490 chr11:65554678 OVOL1 0.43 5.57 0.32 6.1e-8 Urate levels; CESC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.67 0.64 1.54e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11098499 0.909 rs7681978 chr4:120383775 T/C cg09307838 chr4:120376055 NA 0.95 13.79 0.65 5.71e-33 Corneal astigmatism; CESC cis rs751728 1.000 rs755496 chr6:33734376 C/G cg15252951 chr6:33757062 LEMD2 0.46 5.85 0.34 1.41e-8 Crohn's disease; CESC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg16606324 chr3:10149918 C3orf24 0.44 5.49 0.32 9.21e-8 Alzheimer's disease; CESC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg13393036 chr8:95962371 TP53INP1 -0.48 -10.15 -0.53 1.13e-20 Type 2 diabetes; CESC cis rs2108622 0.727 rs62107770 chr19:15985425 A/G cg13772218 chr19:15982569 NA 0.3 5.91 0.34 1.07e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs4969178 0.930 rs2292644 chr17:76394449 C/T cg20026190 chr17:76395443 PGS1 0.49 7.91 0.44 6.98e-14 HDL cholesterol levels; CESC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.51 0.64 5.51e-32 Prudent dietary pattern; CESC cis rs763121 0.853 rs5750649 chr22:39036769 T/C cg21395723 chr22:39101663 GTPBP1 0.5 6.66 0.38 1.6e-10 Menopause (age at onset); CESC cis rs2228479 0.867 rs62052168 chr16:89947203 G/A cg14709524 chr16:89940631 TCF25 0.89 6.56 0.37 2.74e-10 Skin colour saturation; CESC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg02951883 chr7:2050386 MAD1L1 0.42 5.41 0.32 1.4e-7 Bipolar disorder and schizophrenia; CESC cis rs2625529 0.557 rs1000281 chr15:72553422 A/G cg16672083 chr15:72433130 SENP8 0.41 6.17 0.35 2.51e-9 Red blood cell count; CESC cis rs11792861 0.781 rs2151426 chr9:111743797 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 6.64 0.38 1.77e-10 Menarche (age at onset); CESC cis rs2710642 0.576 rs974344 chr2:62883176 C/G cg17519650 chr2:63277830 OTX1 0.46 5.55 0.32 6.82e-8 LDL cholesterol levels;LDL cholesterol; CESC trans rs1814175 0.669 rs12416837 chr11:49669761 G/T cg15704280 chr7:45808275 SEPT13 -0.82 -11.5 -0.58 4.36e-25 Height; CESC cis rs11642862 1.000 rs11642862 chr16:30785824 A/G cg02466173 chr16:30829666 NA 0.53 5.56 0.32 6.73e-8 Tonsillectomy; CESC cis rs1881797 1.000 rs1881797 chr1:247689532 A/G cg21399703 chr1:247681439 NA 0.47 6.98 0.39 2.43e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs2439831 0.867 rs6493082 chr15:43634808 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.46 0.54 1.19e-21 Lung cancer in ever smokers; CESC cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg18512352 chr11:47633146 NA -0.6 -9.02 -0.48 3.9e-17 Subjective well-being; CESC cis rs9905704 0.633 rs2632523 chr17:56506634 G/A cg12560992 chr17:57184187 TRIM37 0.58 5.6 0.33 5.39e-8 Testicular germ cell tumor; CESC cis rs4253772 0.626 rs9615960 chr22:46752307 G/A cg00784671 chr22:46762841 CELSR1 -0.68 -6.08 -0.35 4.2e-9 LDL cholesterol;Cholesterol, total; CESC cis rs11677416 1.000 rs7570215 chr2:113527660 G/T cg27083787 chr2:113543245 IL1A 0.41 5.16 0.3 4.75e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC trans rs8099014 1.000 rs9319929 chr18:56115825 A/C cg06677321 chr17:67603831 NA 0.43 6.01 0.35 6.19e-9 Platelet count; CESC cis rs4604732 0.642 rs4400652 chr1:247636479 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.39 5.5 0.32 9.09e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11122272 0.638 rs2739514 chr1:231514806 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -6.24 -0.36 1.7e-9 Hemoglobin concentration; CESC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs2243480 0.901 rs1701759 chr7:65470932 G/T cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg12365402 chr11:9010492 NRIP3 -0.33 -5.25 -0.31 3.05e-7 Hemoglobin concentration; CESC cis rs2832077 0.527 rs59730679 chr21:30226244 T/C cg08807101 chr21:30365312 RNF160 -0.66 -8.57 -0.47 8.73e-16 Cognitive test performance; CESC cis rs7666738 0.830 rs7697315 chr4:98938764 T/C cg05340658 chr4:99064831 C4orf37 0.79 11.74 0.58 6.86e-26 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg25036284 chr2:26402008 FAM59B -0.73 -8.35 -0.46 3.78e-15 Gut microbiome composition (summer); CESC cis rs116095464 0.867 rs7726582 chr5:215349 C/G cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.5 0.32 8.91e-8 Breast cancer; CESC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs926938 0.520 rs969273 chr1:115256669 G/A cg12756093 chr1:115239321 AMPD1 -0.52 -6.34 -0.36 9.75e-10 Autism; CESC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.64 0.43 3.85e-13 Prudent dietary pattern; CESC cis rs4975616 0.869 rs452932 chr5:1330253 T/C cg26373071 chr5:1325741 CLPTM1L 0.43 6.91 0.39 3.59e-11 Lung cancer; CESC cis rs1401999 0.714 rs13066518 chr3:183635498 T/A cg01324343 chr3:183735012 ABCC5 0.5 9.97 0.52 4.5e-20 Anterior chamber depth; CESC cis rs2274273 0.905 rs2147961 chr14:55585381 T/C cg04306507 chr14:55594613 LGALS3 0.31 6.18 0.36 2.38e-9 Protein biomarker; CESC cis rs763121 0.853 rs6519119 chr22:38989007 C/G cg06544989 chr22:39130855 UNC84B 0.5 8.31 0.45 4.85e-15 Menopause (age at onset); CESC trans rs921968 0.541 rs496674 chr2:219432569 G/A cg15547669 chr20:2781122 CPXM1 0.36 6.01 0.35 5.97e-9 Mean corpuscular hemoglobin concentration; CESC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs881375 0.967 rs10739580 chr9:123695282 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.2 0.3 4.07e-7 Rheumatoid arthritis; CESC cis rs787274 1.000 rs1418410 chr9:115465282 A/G cg13803584 chr9:115635662 SNX30 0.53 5.07 0.3 7.4e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7584330 0.737 rs1497129 chr2:238369184 C/T cg14458575 chr2:238380390 NA 0.61 8.58 0.47 7.98e-16 Prostate cancer; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg13445258 chr3:128369860 RPN1 0.54 7.0 0.4 2.07e-11 Tetralogy of Fallot; CESC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg19163074 chr7:65112434 INTS4L2 0.4 5.16 0.3 4.86e-7 Aortic root size; CESC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg14196790 chr5:131705035 SLC22A5 0.34 5.15 0.3 5.02e-7 Blood metabolite levels; CESC cis rs3741151 0.764 rs79892955 chr11:73096280 G/T cg17517138 chr11:73019481 ARHGEF17 0.84 6.34 0.36 9.67e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs3857067 0.806 rs6825522 chr4:95108140 G/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.05 -0.49 3.25e-17 QT interval; CESC cis rs2019216 0.542 rs3829569 chr17:21909222 T/C cg22648282 chr17:21454238 C17orf51 -0.44 -5.96 -0.34 7.89e-9 Pelvic organ prolapse; CESC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg26314531 chr2:26401878 FAM59B 0.67 6.4 0.37 6.88e-10 Gut microbiome composition (summer); CESC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg27535305 chr1:53392650 SCP2 0.3 5.37 0.31 1.75e-7 Monocyte count; CESC cis rs9488822 0.676 rs3798227 chr6:116324898 A/G cg05304507 chr6:116381966 FRK 0.26 6.56 0.37 2.82e-10 Cholesterol, total;LDL cholesterol; CESC cis rs523516 0.645 rs657723 chr17:37319103 T/C cg20555674 chr17:37321631 ARL5C 0.39 6.5 0.37 3.86e-10 IgG glycosylation; CESC cis rs10751667 0.714 rs7395879 chr11:963855 G/C cg06064525 chr11:970664 AP2A2 -0.47 -9.32 -0.5 4.88e-18 Alzheimer's disease (late onset); CESC cis rs7129220 0.660 rs61878632 chr11:10136032 A/C cg01453529 chr11:10209919 SBF2 -0.48 -5.62 -0.33 4.73e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs6964587 0.692 rs7807490 chr7:91773359 A/G cg17063962 chr7:91808500 NA 0.44 6.41 0.37 6.51e-10 Breast cancer; CESC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs9300255 0.602 rs949142 chr12:123634043 T/C cg19016782 chr12:123741754 C12orf65 -0.37 -5.04 -0.3 8.55e-7 Neutrophil percentage of white cells; CESC cis rs7107174 0.892 rs2512534 chr11:77970039 T/A cg02023728 chr11:77925099 USP35 0.48 6.34 0.36 9.87e-10 Testicular germ cell tumor; CESC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg18876405 chr7:65276391 NA -0.5 -6.67 -0.38 1.46e-10 Aortic root size; CESC cis rs4664308 1.000 rs17341301 chr2:160902420 G/A cg03641300 chr2:160917029 PLA2R1 -0.65 -9.55 -0.51 9.19e-19 Idiopathic membranous nephropathy; CESC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg26343298 chr8:95960752 TP53INP1 0.36 5.96 0.34 7.8e-9 Type 2 diabetes; CESC cis rs6456156 0.586 rs1358883 chr6:167467433 C/G cg07741184 chr6:167504864 NA -0.34 -5.85 -0.34 1.47e-8 Primary biliary cholangitis; CESC cis rs9488822 0.676 rs12202181 chr6:116327102 A/G cg26893134 chr6:116381904 FRK 0.25 6.02 0.35 5.89e-9 Cholesterol, total;LDL cholesterol; CESC cis rs2380220 0.541 rs72928283 chr6:96082490 A/C cg15832292 chr6:96025679 MANEA -0.78 -8.11 -0.45 1.94e-14 Behavioural disinhibition (generation interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg07541786 chr7:12610355 SCIN -0.44 -6.07 -0.35 4.5e-9 Height; CESC cis rs2996428 0.667 rs11578070 chr1:3769871 G/C cg13057898 chr1:3703894 LRRC47 0.45 6.09 0.35 3.87e-9 Red cell distribution width; CESC cis rs4664308 1.000 rs56297666 chr2:160902023 G/C cg03641300 chr2:160917029 PLA2R1 -0.66 -9.75 -0.51 2.16e-19 Idiopathic membranous nephropathy; CESC cis rs3733585 0.753 rs1122141 chr4:9947278 T/C cg00071950 chr4:10020882 SLC2A9 -0.78 -14.02 -0.65 8.94e-34 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3126085 0.877 rs1552996 chr1:152171104 C/A cg26876637 chr1:152193138 HRNR 0.44 5.09 0.3 6.66e-7 Atopic dermatitis; CESC cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg11752832 chr7:134001865 SLC35B4 0.52 6.71 0.38 1.2e-10 Mean platelet volume; CESC cis rs6540556 0.682 rs932335 chr1:209905734 G/C cg05527609 chr1:210001259 C1orf107 -0.61 -6.69 -0.38 1.34e-10 Red blood cell count; CESC cis rs12410462 0.581 rs12402691 chr1:227543693 G/A cg04117972 chr1:227635322 NA 0.6 5.08 0.3 7.29e-7 Major depressive disorder; CESC cis rs8114671 0.804 rs3803936 chr20:33632775 T/C cg07148914 chr20:33460835 GGT7 -0.41 -5.31 -0.31 2.28e-7 Height; CESC cis rs11997175 0.545 rs66584807 chr8:33667609 A/G ch.8.33884649F chr8:33765107 NA 0.55 6.81 0.39 6.5e-11 Body mass index; CESC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg18876405 chr7:65276391 NA -0.68 -9.52 -0.5 1.1e-18 Aortic root size; CESC cis rs3818285 0.655 rs588160 chr10:111641538 C/T cg00817464 chr10:111662876 XPNPEP1 0.48 7.46 0.42 1.23e-12 Superior crus of antihelix expression; CESC cis rs7134594 0.677 rs9668180 chr12:109860597 T/G cg19025524 chr12:109796872 NA -0.41 -5.93 -0.34 9.34e-9 HDL cholesterol; CESC cis rs7248779 0.512 rs12610522 chr19:2413228 C/T cg22729335 chr19:2427816 TIMM13 1.11 20.27 0.78 8.38e-56 Cortisol levels (saliva); CESC cis rs9911578 1.000 rs1631237 chr17:56734695 A/G cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC cis rs2243480 1.000 rs160634 chr7:65528664 C/T cg18252515 chr7:66147081 NA 1.01 10.44 0.54 1.3e-21 Diabetic kidney disease; CESC cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg13175981 chr1:150552382 MCL1 0.63 9.33 0.5 4.42e-18 Tonsillectomy; CESC cis rs6032067 0.929 rs35475980 chr20:43821080 A/T cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.53e-7 Blood protein levels; CESC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg25067162 chr17:41277974 BRCA1;NBR2 -0.45 -6.33 -0.36 1.07e-9 Menopause (age at onset); CESC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.5 -0.37 4.04e-10 Bipolar disorder; CESC cis rs10504229 0.906 rs2270608 chr8:58194688 T/C cg22535103 chr8:58192502 C8orf71 -1.07 -13.39 -0.64 1.44e-31 Developmental language disorder (linguistic errors); CESC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg18769074 chr3:133464867 TF 0.3 5.34 0.31 1.98e-7 Iron status biomarkers; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20165655 chr11:65339703 FAM89B 0.47 6.41 0.37 6.67e-10 Gut microbiota (bacterial taxa); CESC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.09 -0.3 6.68e-7 Bipolar disorder; CESC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg18402987 chr7:1209562 NA 0.74 7.26 0.41 4.18e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7084402 1.000 rs7074778 chr10:60272248 C/T cg07615347 chr10:60278583 BICC1 -0.58 -9.2 -0.49 1.1e-17 Refractive error; CESC cis rs6584283 1.000 rs6584283 chr10:101290301 A/G cg09788492 chr10:101292477 NKX2-3 0.32 5.84 0.34 1.55e-8 Ulcerative colitis; CESC cis rs832540 0.519 rs6895442 chr5:56260998 T/C cg12311346 chr5:56204834 C5orf35 -0.44 -5.52 -0.32 8.09e-8 Coronary artery disease; CESC cis rs1712517 0.873 rs7913461 chr10:105001325 A/G cg05636881 chr10:105038444 INA 0.29 5.09 0.3 6.86e-7 Migraine; CESC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg16405210 chr4:1374714 KIAA1530 -0.6 -8.01 -0.44 3.6e-14 Longevity; CESC cis rs4853012 0.887 rs2280642 chr2:74358252 T/A cg01017244 chr2:74357527 NA 0.73 10.07 0.53 2.09e-20 Gestational age at birth (maternal effect); CESC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.57 6.99 0.39 2.29e-11 Tonsillectomy; CESC cis rs4955124 0.730 rs59870036 chr3:32044252 G/A cg05935571 chr3:32023257 ZNF860;OSBPL10 0.8 5.93 0.34 9.37e-9 Schizophrenia; CESC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs10754283 0.967 rs1934045 chr1:90107799 A/C cg21401794 chr1:90099060 LRRC8C -0.69 -9.25 -0.49 7.8e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7771547 0.573 rs629721 chr6:36398229 T/C cg07856975 chr6:36356162 ETV7 0.36 5.38 0.31 1.67e-7 Platelet distribution width; CESC cis rs3015497 0.626 rs7150204 chr14:51137355 T/C cg09863266 chr14:51125203 SAV1 -0.35 -5.39 -0.31 1.59e-7 Mean platelet volume; CESC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.66 -0.33 4.01e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6964587 0.869 rs6946764 chr7:91539003 A/G cg17063962 chr7:91808500 NA -0.53 -7.0 -0.4 2.06e-11 Breast cancer; CESC cis rs1595825 0.891 rs16867018 chr2:198521490 C/T cg10820045 chr2:198174542 NA 0.41 5.21 0.3 3.79e-7 Ulcerative colitis; CESC cis rs6696846 0.515 rs12136320 chr1:205110946 T/C cg00857998 chr1:205179979 DSTYK 0.42 5.53 0.32 7.52e-8 Red blood cell count; CESC cis rs6598955 0.671 rs17163866 chr1:26648088 A/G cg19743891 chr1:26644573 UBXN11;CD52 0.38 5.44 0.32 1.24e-7 Obesity-related traits; CESC cis rs34330 0.562 rs11055025 chr12:12866619 A/T cg09462578 chr12:12878428 APOLD1 -0.7 -7.6 -0.42 5.26e-13 Systemic lupus erythematosus; CESC cis rs950776 0.593 rs6495306 chr15:78865893 C/T cg06917634 chr15:78832804 PSMA4 -0.61 -8.18 -0.45 1.19e-14 Sudden cardiac arrest; CESC cis rs79976124 0.760 rs74295030 chr6:66654441 T/C cg07460842 chr6:66804631 NA 0.74 8.77 0.47 2.22e-16 Type 2 diabetes; CESC cis rs10739663 0.520 rs1566362 chr9:128163132 C/T cg14078157 chr9:128172775 NA 0.33 5.16 0.3 4.77e-7 Resting heart rate; CESC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -11.84 -0.59 2.96e-26 Gut microbiome composition (summer); CESC cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.78 9.62 0.51 5.44e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.1 0.3 6.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs7107174 0.892 rs12284390 chr11:78103902 C/A cg02023728 chr11:77925099 USP35 0.47 6.17 0.35 2.54e-9 Testicular germ cell tumor; CESC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg27535305 chr1:53392650 SCP2 0.35 6.13 0.35 3.1e-9 Monocyte count; CESC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg17724175 chr1:150552817 MCL1 -0.5 -7.92 -0.44 6.38e-14 Blood protein levels; CESC cis rs7666738 0.648 rs33988750 chr4:98985386 T/C cg17366294 chr4:99064904 C4orf37 0.55 5.99 0.35 6.79e-9 Colonoscopy-negative controls vs population controls; CESC cis rs12765878 1.000 rs11191843 chr10:105648651 G/C cg11005552 chr10:105648138 OBFC1 0.35 5.06 0.3 7.92e-7 Coronary artery disease; CESC trans rs10435719 0.834 rs11250176 chr8:11792816 A/G cg15556689 chr8:8085844 FLJ10661 0.51 6.3 0.36 1.22e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CESC trans rs561341 0.830 rs2301765 chr17:30202056 T/A cg20587970 chr11:113659929 NA 0.99 11.71 0.58 8.33e-26 Hip circumference adjusted for BMI; CESC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg17376030 chr22:41985996 PMM1 0.73 7.98 0.44 4.57e-14 Vitiligo; CESC cis rs7647973 1.000 rs9860055 chr3:49506900 C/T cg07636037 chr3:49044803 WDR6 -0.72 -10.25 -0.53 5.58e-21 Menarche (age at onset); CESC cis rs3020736 0.500 rs5996109 chr22:42493098 A/G cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg22800045 chr5:56110881 MAP3K1 0.83 9.98 0.52 3.92e-20 Initial pursuit acceleration; CESC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg08027265 chr7:2291960 NA -0.37 -5.53 -0.32 7.61e-8 Bipolar disorder and schizophrenia; CESC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.33 0.31 2.07e-7 Tonsillectomy; CESC cis rs10504229 0.861 rs67966192 chr8:58188172 A/C cg22535103 chr8:58192502 C8orf71 -0.87 -11.24 -0.57 3.19e-24 Developmental language disorder (linguistic errors); CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg27194152 chr7:157982427 PTPRN2 0.34 5.42 0.32 1.35e-7 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.791 rs2081622 chr4:98927369 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg24829409 chr8:58192753 C8orf71 -0.75 -9.86 -0.52 9.69e-20 Developmental language disorder (linguistic errors); CESC cis rs1023500 0.551 rs2859438 chr22:42466980 A/T cg12850546 chr22:42539477 CYP2D7P1 -0.43 -5.15 -0.3 5.05e-7 Schizophrenia; CESC cis rs56309584 0.673 rs12451139 chr17:8119626 G/T cg06726167 chr17:8076949 TMEM107 -0.5 -5.1 -0.3 6.44e-7 Initial pursuit acceleration; CESC cis rs28374715 0.681 rs11629979 chr15:41626579 A/G cg20272979 chr15:41787780 ITPKA 0.39 5.21 0.3 3.76e-7 Ulcerative colitis; CESC cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.83 8.86 0.48 1.15e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.54 -6.9 -0.39 3.91e-11 Tuberculosis; CESC cis rs9611565 0.512 rs4512 chr22:42206084 G/C cg06481639 chr22:41940642 POLR3H -0.61 -5.9 -0.34 1.09e-8 Vitiligo; CESC cis rs2304069 0.507 rs13167061 chr5:149388624 T/G cg12661370 chr5:149340060 SLC26A2 0.47 6.27 0.36 1.49e-9 HIV-1 control; CESC cis rs561341 0.660 rs7406043 chr17:30220152 C/G cg12193833 chr17:30244370 NA -0.58 -6.06 -0.35 4.77e-9 Hip circumference adjusted for BMI; CESC trans rs9467711 0.606 rs72836482 chr6:26359241 A/T cg06606381 chr12:133084897 FBRSL1 -0.76 -6.87 -0.39 4.66e-11 Autism spectrum disorder or schizophrenia; CESC cis rs4604732 0.631 rs4411161 chr1:247632374 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.49 6.11 0.35 3.52e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs10911232 0.524 rs10737238 chr1:183025303 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.5 0.64 5.97e-32 Hypertriglyceridemia; CESC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg08968635 chr6:28129556 ZNF389 0.41 5.53 0.32 7.61e-8 Depression; CESC trans rs208520 0.661 rs1776361 chr6:66822270 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -13.01 -0.62 3.05e-30 Exhaled nitric oxide output; CESC cis rs1387259 0.839 rs7487682 chr12:48579665 A/C cg24011408 chr12:48396354 COL2A1 -0.47 -7.02 -0.4 1.82e-11 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs6748734 1.000 rs4675863 chr2:241830763 A/T cg07537917 chr2:241836409 C2orf54 -0.25 -5.17 -0.3 4.61e-7 Urinary metabolites; CESC cis rs2204008 0.627 rs11176531 chr12:38152166 T/G cg13010199 chr12:38710504 ALG10B 0.52 6.26 0.36 1.52e-9 Bladder cancer; CESC cis rs4642101 0.824 rs9820977 chr3:12842932 G/A cg05775895 chr3:12838266 CAND2 0.39 5.78 0.33 2.1e-8 QRS complex (12-leadsum); CESC cis rs12956009 0.583 rs1821446 chr18:44894422 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.78 0.38 8e-11 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16321474 chr12:48299386 VDR 0.49 6.05 0.35 5.04e-9 Gut microbiome composition (summer); CESC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg04315214 chr1:2043799 PRKCZ 0.64 11.39 0.57 9.95e-25 Height; CESC cis rs11969893 0.850 rs9485417 chr6:101300038 C/T cg12253828 chr6:101329408 ASCC3 -1.14 -10.08 -0.53 1.91e-20 Economic and political preferences (immigration/crime); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17249942 chr21:45660288 ICOSLG 0.61 6.59 0.38 2.35e-10 Gut microbiome composition (summer); CESC cis rs11958404 0.789 rs72818145 chr5:157476552 G/C cg05962755 chr5:157440814 NA 0.62 7.23 0.41 5.17e-12 IgG glycosylation; CESC cis rs11711311 1.000 rs7645473 chr3:113516187 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.59 7.86 0.43 9.7e-14 IgG glycosylation; CESC cis rs4604732 0.631 rs12039596 chr1:247624766 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1401999 0.966 rs1533682 chr3:183634879 A/G cg01324343 chr3:183735012 ABCC5 0.64 13.43 0.64 9.95e-32 Anterior chamber depth; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21721210 chr19:39574878 PAPL 0.59 7.51 0.42 8.82e-13 Gut microbiome composition (summer); CESC cis rs4727027 0.680 rs6464941 chr7:148826352 A/G cg23158103 chr7:148848205 ZNF398 -0.34 -5.17 -0.3 4.72e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs8103278 1.000 rs8108864 chr19:46301671 G/A cg11657440 chr19:46296263 DMWD -0.58 -7.23 -0.41 5.09e-12 Coronary artery disease; CESC cis rs9303401 0.659 rs34556735 chr17:56694447 A/C cg10487724 chr17:56770010 TEX14;RAD51C 1.03 11.8 0.59 4.12e-26 Cognitive test performance; CESC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg22143856 chr6:28129313 ZNF389 0.51 6.62 0.38 2e-10 Depression; CESC cis rs1707322 0.686 rs2230658 chr1:46078854 A/G cg03146154 chr1:46216737 IPP -0.79 -10.71 -0.55 1.73e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg02398342 chr17:80708632 TBCD;FN3K 0.46 5.47 0.32 1.03e-7 Glycated hemoglobin levels; CESC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg24110177 chr3:50126178 RBM5 0.52 7.2 0.4 6.12e-12 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs3105593 1.000 rs3848129 chr15:50892064 C/T cg08437265 chr15:50716283 USP8 0.42 5.4 0.31 1.5e-7 QT interval; CESC cis rs2276314 1.000 rs8086395 chr18:33564592 C/G cg05985134 chr18:33552581 C18orf21 0.64 7.43 0.42 1.5e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs13064411 0.696 rs1486897 chr3:113215818 G/A cg18753928 chr3:113234510 CCDC52 -0.48 -5.62 -0.33 4.91e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs7267979 0.966 rs2500433 chr20:25296335 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.08 -0.7 4.65e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs8060686 0.920 rs73591968 chr16:67803063 G/A cg26727032 chr16:67993705 SLC12A4 -0.58 -6.02 -0.35 5.68e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg10494973 chr17:80897199 TBCD 0.5 5.52 0.32 7.95e-8 Breast cancer; CESC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.16 0.4 7.99e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg12373951 chr3:133503437 NA 0.42 6.19 0.36 2.31e-9 Iron status biomarkers; CESC cis rs7523050 0.730 rs41279678 chr1:109440215 G/A cg08274380 chr1:109419600 GPSM2 0.91 6.37 0.36 8.46e-10 Fat distribution (HIV); CESC cis rs3540 0.618 rs11636089 chr15:91039527 C/T cg22089800 chr15:90895588 ZNF774 0.64 8.73 0.47 2.93e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg00106254 chr7:1943704 MAD1L1 -0.47 -5.93 -0.34 9.22e-9 Bipolar disorder and schizophrenia; CESC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg08470875 chr2:26401718 FAM59B -0.46 -5.12 -0.3 5.98e-7 Gut microbiome composition (summer); CESC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg21433313 chr16:3507492 NAT15 -0.62 -6.71 -0.38 1.15e-10 Tuberculosis; CESC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg16278512 chr7:12443529 VWDE -0.53 -6.67 -0.38 1.47e-10 Coronary artery disease; CESC trans rs4906172 0.773 rs34509705 chr14:102513044 C/G cg17920195 chr4:129149383 NA 0.32 6.07 0.35 4.43e-9 Menopause (age at onset); CESC trans rs11165623 0.792 rs2104236 chr1:96908690 C/T cg10631902 chr5:14652156 NA -0.55 -8.26 -0.45 7.06e-15 Hip circumference;Waist circumference; CESC cis rs9905704 0.918 rs11657676 chr17:56842043 A/G cg12560992 chr17:57184187 TRIM37 0.61 7.12 0.4 9.95e-12 Testicular germ cell tumor; CESC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.72 0.33 2.85e-8 Depression; CESC cis rs4728302 0.934 rs2971963 chr7:133641505 A/G cg10665199 chr7:133106180 EXOC4 -0.37 -5.04 -0.3 8.73e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 7.42 0.41 1.55e-12 Bipolar disorder; CESC cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.32 0.6 7.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg07701084 chr6:150067640 NUP43 0.49 6.81 0.39 6.47e-11 Lung cancer; CESC cis rs9309711 0.737 rs9284795 chr2:3492065 G/A cg10845886 chr2:3471009 TTC15 -0.79 -10.76 -0.55 1.19e-22 Neurofibrillary tangles; CESC cis rs17826219 0.500 rs2874724 chr17:29072433 T/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Body mass index; CESC cis rs3733585 0.577 rs28558552 chr4:9964913 G/A cg00071950 chr4:10020882 SLC2A9 -0.69 -10.57 -0.54 5.1e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2404602 0.684 rs4886819 chr15:76901698 C/T cg23625390 chr15:77176239 SCAPER -0.45 -6.16 -0.35 2.64e-9 Blood metabolite levels; CESC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg03240473 chr21:43526662 UMODL1;C21orf128 -0.42 -5.25 -0.31 3.17e-7 IgG glycosylation; CESC trans rs629535 0.773 rs569064 chr8:70065967 A/G cg21567404 chr3:27674614 NA 0.88 10.34 0.54 2.74e-21 Dupuytren's disease; CESC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.16 0.3 4.73e-7 Bipolar disorder; CESC cis rs28829049 0.861 rs67113006 chr1:19376566 A/G cg13387374 chr1:19411106 UBR4 0.47 5.82 0.34 1.67e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs34779708 0.733 rs11010146 chr10:35541561 T/A cg04310649 chr10:35416472 CREM -0.47 -5.39 -0.31 1.59e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs9309711 0.736 rs13409102 chr2:3496321 G/A cg10845886 chr2:3471009 TTC15 -0.8 -9.61 -0.51 6.12e-19 Neurofibrillary tangles; CESC cis rs727563 0.555 rs5751136 chr22:42075581 T/A cg17376030 chr22:41985996 PMM1 -0.62 -6.96 -0.39 2.66e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs910316 0.763 rs12588981 chr14:75460561 A/G cg08847533 chr14:75593920 NEK9 0.89 15.3 0.68 2.72e-38 Height; CESC cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg11812906 chr14:75593930 NEK9 0.91 15.39 0.69 1.24e-38 Height; CESC cis rs1008375 0.966 rs12503517 chr4:17698725 G/A cg16339924 chr4:17578868 LAP3 0.58 7.19 0.4 6.76e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs5167 0.566 rs204905 chr19:45460764 G/A cg13119609 chr19:45449297 APOC2 0.54 8.36 0.46 3.48e-15 Blood protein levels; CESC cis rs2736345 0.516 rs7844858 chr8:11392659 T/A cg09528494 chr8:11338675 NA 0.32 5.93 0.34 9.53e-9 Sjögren's syndrome;Systemic lupus erythematosus; CESC cis rs1048238 0.506 rs848209 chr1:16256007 T/C cg22431228 chr1:16359049 CLCNKA 0.36 6.14 0.35 2.93e-9 Systolic blood pressure; CESC cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg05347473 chr6:146136440 FBXO30 -0.57 -7.36 -0.41 2.27e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs697003 0.705 rs701926 chr1:211851619 G/T cg26036067 chr1:211849175 NEK2 -0.48 -5.76 -0.33 2.31e-8 Red cell distribution width; CESC cis rs4141404 0.828 rs2413043 chr22:31648576 G/T cg02404636 chr22:31891804 SFI1 -0.39 -5.08 -0.3 7.3e-7 Paclitaxel-induced neuropathy; CESC cis rs10751667 0.621 rs10794348 chr11:939941 G/A cg20946044 chr11:1010712 AP2A2 -0.41 -5.64 -0.33 4.31e-8 Alzheimer's disease (late onset); CESC cis rs9309473 1.000 rs1534471 chr2:73647508 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.41 -0.37 6.68e-10 Metabolite levels; CESC cis rs208520 0.802 rs4710315 chr6:66887594 A/G cg07460842 chr6:66804631 NA -0.94 -12.15 -0.6 2.75e-27 Exhaled nitric oxide output; CESC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg13628971 chr7:2884303 GNA12 0.58 7.41 0.41 1.73e-12 Height; CESC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg04282206 chr17:62833786 PLEKHM1P 0.54 6.22 0.36 1.95e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg23462726 chr11:62437636 C11orf83;C11orf48 -0.39 -5.13 -0.3 5.69e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs3780486 0.957 rs10971434 chr9:33168891 C/A cg20290983 chr6:43655470 MRPS18A 0.82 11.55 0.58 2.82e-25 IgG glycosylation; CESC cis rs9814567 0.964 rs12492930 chr3:134222722 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.98 -0.34 7.14e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03383472 chr7:2314947 SNX8 0.48 6.57 0.37 2.66e-10 Fibrinogen levels; CESC cis rs2243480 1.000 rs68189316 chr7:65409169 C/G cg13147721 chr7:65941812 NA -0.85 -8.1 -0.45 2e-14 Diabetic kidney disease; CESC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg24675658 chr1:53192096 ZYG11B -0.66 -8.7 -0.47 3.67e-16 Monocyte count; CESC cis rs4746818 0.711 rs4745976 chr10:70845181 A/G cg11621586 chr10:70884670 VPS26A 0.57 6.11 0.35 3.5e-9 Left atrial antero-posterior diameter; CESC cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg02297831 chr4:17616191 MED28 0.6 7.7 0.43 2.76e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg27170947 chr2:26402098 FAM59B -0.6 -7.08 -0.4 1.26e-11 Gut microbiome composition (summer); CESC cis rs950776 0.684 rs11637635 chr15:78877150 A/G cg06917634 chr15:78832804 PSMA4 -0.53 -6.54 -0.37 3.19e-10 Sudden cardiac arrest; CESC cis rs2108622 0.683 rs56228205 chr19:15981973 A/C cg13772218 chr19:15982569 NA 0.29 5.76 0.33 2.32e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs12971120 0.891 rs12968731 chr18:72169708 G/T cg26446133 chr18:72167187 CNDP2 -0.77 -9.8 -0.52 1.46e-19 Refractive error; CESC cis rs11750568 0.967 rs6864287 chr5:178515091 T/C cg10208897 chr5:178548229 ADAMTS2 0.37 5.26 0.31 3.04e-7 Height; CESC cis rs265548 0.646 rs36689 chr19:17910639 A/G cg04517722 chr19:17905589 B3GNT3 0.42 5.5 0.32 9.07e-8 Tumor biomarkers; CESC cis rs9457247 0.902 rs366938 chr6:167403538 T/C cg23791538 chr6:167370224 RNASET2 -0.58 -8.28 -0.45 6.16e-15 Crohn's disease; CESC cis rs9303401 0.614 rs2333409 chr17:57139134 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.88 11.13 0.56 7.31e-24 Cognitive test performance; CESC cis rs909674 0.515 rs9611170 chr22:39784845 G/C cg01416388 chr22:39784598 NA -0.64 -8.17 -0.45 1.25e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs826838 0.838 rs11183646 chr12:38799846 A/T cg26384229 chr12:38710491 ALG10B 0.83 14.61 0.67 7.23e-36 Heart rate; CESC cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg04450456 chr4:17643702 FAM184B 0.36 5.06 0.3 7.87e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16280946 chr22:20716554 NA 0.45 6.24 0.36 1.71e-9 Fibrinogen levels; CESC cis rs7845219 0.544 rs7017487 chr8:95922752 A/G cg16049864 chr8:95962084 TP53INP1 0.48 7.23 0.41 5.16e-12 Type 2 diabetes; CESC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg02951883 chr7:2050386 MAD1L1 -0.52 -6.72 -0.38 1.14e-10 Bipolar disorder and schizophrenia; CESC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg01411255 chr17:61851458 DDX42;CCDC47 1.04 16.58 0.71 7.85e-43 Height; CESC cis rs6942756 1.000 rs2402945 chr7:128956256 C/A cg02491457 chr7:128862824 NA -0.69 -9.36 -0.5 3.61e-18 White matter hyperintensity burden; CESC cis rs1185460 0.904 rs1003081 chr11:118913993 A/G cg23280166 chr11:118938394 VPS11 -0.42 -5.89 -0.34 1.16e-8 Coronary artery disease; CESC cis rs7937682 0.601 rs2187388 chr11:111387116 C/T cg09085632 chr11:111637200 PPP2R1B 0.47 5.56 0.32 6.6e-8 Primary sclerosing cholangitis; CESC cis rs11723261 0.621 rs6599306 chr4:143439 C/G cg12746427 chr4:53362 ZNF718;ZNF595 -0.42 -5.07 -0.3 7.47e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs2479724 0.776 rs2250428 chr6:41832772 T/A cg17623882 chr6:41773611 USP49 -0.41 -5.83 -0.34 1.58e-8 Menarche (age at onset); CESC cis rs9814567 1.000 rs3932818 chr3:134206069 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.76 -0.33 2.32e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg11764359 chr7:65958608 NA -0.8 -11.89 -0.59 2.01e-26 Aortic root size; CESC trans rs208520 0.690 rs3899423 chr6:66835285 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -12.87 -0.62 8.91e-30 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02375201 chr1:27114675 PIGV 0.6 6.36 0.36 8.72e-10 Gut microbiome composition (summer); CESC cis rs8114671 0.836 rs2104083 chr20:33649133 G/A cg07148914 chr20:33460835 GGT7 -0.4 -5.11 -0.3 6.21e-7 Height; CESC cis rs965513 1.000 rs7032019 chr9:100548144 G/A cg13688889 chr9:100608707 NA -0.6 -8.62 -0.47 6.27e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg02018176 chr4:1364513 KIAA1530 0.41 5.88 0.34 1.26e-8 Longevity; CESC cis rs9549367 0.713 rs3024744 chr13:113821477 A/C cg18105134 chr13:113819100 PROZ -0.66 -8.18 -0.45 1.23e-14 Platelet distribution width; CESC cis rs977987 0.751 rs56004344 chr16:75474189 T/C cg03315344 chr16:75512273 CHST6 0.43 6.12 0.35 3.35e-9 Dupuytren's disease; CESC cis rs2276314 1.000 rs4799832 chr18:33559646 T/C cg19628046 chr18:33552617 C18orf21 0.55 6.14 0.35 2.99e-9 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7216064 1.000 rs8079754 chr17:65887896 A/G cg12091567 chr17:66097778 LOC651250 -0.74 -7.57 -0.42 6.29e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.91 -10.18 -0.53 9.02e-21 Mean platelet volume; CESC cis rs2985684 0.846 rs10150624 chr14:50051565 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.43 -5.25 -0.31 3.09e-7 Carotid intima media thickness; CESC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 8.93 0.48 7.46e-17 Platelet count; CESC cis rs796364 0.760 rs1569178 chr2:201024512 T/C cg23649088 chr2:200775458 C2orf69 -0.6 -5.16 -0.3 4.78e-7 Schizophrenia; CESC cis rs4268898 0.931 rs55642516 chr2:24502305 A/G cg20701182 chr2:24300061 SF3B14 0.46 5.64 0.33 4.27e-8 Asthma; CESC cis rs6674176 0.660 rs2108202 chr1:44395786 A/G cg23954153 chr1:44402353 ARTN 0.33 5.18 0.3 4.36e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs61869271 0.799 rs35501899 chr10:116739109 T/G cg23260525 chr10:116636907 FAM160B1 0.3 5.24 0.31 3.21e-7 Tonsillectomy; CESC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg18402987 chr7:1209562 NA 0.72 7.2 0.4 6.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3768617 0.510 rs7518957 chr1:183093028 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.86 -14.2 -0.66 2.07e-34 Fuchs's corneal dystrophy; CESC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.23 -0.31 3.53e-7 Life satisfaction; CESC cis rs3796619 1.000 rs3796619 chr4:1095281 A/G cg27284194 chr4:1044797 NA 0.38 5.74 0.33 2.58e-8 Recombination rate (males); CESC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.9 10.21 0.53 7.26e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2354432 0.556 rs59180647 chr1:146772062 C/T cg25205988 chr1:146714368 CHD1L -1.0 -8.9 -0.48 9.01e-17 Mitochondrial DNA levels; CESC cis rs1018836 0.570 rs6471084 chr8:91463666 T/C cg16814680 chr8:91681699 NA -0.51 -6.88 -0.39 4.41e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2236918 1.000 rs1629051 chr1:242026344 A/G cg17736920 chr1:242011382 EXO1 -0.66 -8.71 -0.47 3.31e-16 Menopause (age at onset); CESC cis rs36051895 0.659 rs7859390 chr9:5062473 A/T cg02405213 chr9:5042618 JAK2 -0.47 -5.65 -0.33 4.1e-8 Pediatric autoimmune diseases; CESC cis rs72781680 0.898 rs72798049 chr2:23958002 C/G cg08917208 chr2:24149416 ATAD2B 0.96 8.67 0.47 4.28e-16 Lymphocyte counts; CESC trans rs7618501 0.633 rs2008877 chr3:50162291 T/G cg21659725 chr3:3221576 CRBN -0.49 -6.69 -0.38 1.3100000000000001e-10 Intelligence (multi-trait analysis); CESC cis rs6089584 1.000 rs3787425 chr20:60559256 C/T cg06108461 chr20:60628389 TAF4 -0.78 -11.36 -0.57 1.25e-24 Body mass index; CESC cis rs3015497 0.646 rs3015494 chr14:51115157 C/T cg26011998 chr14:51135199 SAV1 -0.56 -6.27 -0.36 1.45e-9 Mean platelet volume; CESC cis rs6783573 0.965 rs3806703 chr3:46618501 T/C cg21489266 chr3:46619131 LRRC2;TDGF1 -0.45 -6.47 -0.37 4.7e-10 Cerebrospinal fluid biomarker levels; CESC cis rs5769707 0.967 rs763126 chr22:49988574 G/T cg05373962 chr22:49881684 NA 0.36 6.15 0.35 2.88e-9 Monocyte count;Monocyte percentage of white cells; CESC cis rs9400271 0.632 rs34981677 chr6:109590920 T/C cg01475377 chr6:109611718 NA -0.46 -7.13 -0.4 9.29e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs4925386 0.840 rs6143035 chr20:60920700 C/T cg24112000 chr20:60950667 NA 0.45 5.55 0.32 6.91e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg08027265 chr7:2291960 NA -0.41 -6.28 -0.36 1.35e-9 Bipolar disorder and schizophrenia; CESC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg23161317 chr6:28129485 ZNF389 0.47 5.88 0.34 1.21e-8 Depression; CESC cis rs12142240 0.667 rs66990604 chr1:46822073 G/A cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs963731 0.649 rs2373495 chr2:39254627 C/G cg04010122 chr2:39346883 SOS1 -0.73 -5.35 -0.31 1.87e-7 Corticobasal degeneration; CESC cis rs7264396 0.563 rs6060566 chr20:34288226 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.9 -10.87 -0.56 5.11e-23 Total cholesterol levels; CESC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg14983838 chr19:29218262 NA 0.5 6.16 0.35 2.67e-9 Methadone dose in opioid dependence; CESC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg04944784 chr2:26401820 FAM59B 0.96 10.5 0.54 8.76e-22 Gut microbiome composition (summer); CESC cis rs7264396 0.690 rs2425170 chr20:34442672 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.24 0.41 4.85e-12 Total cholesterol levels; CESC cis rs1256061 0.603 rs1256038 chr14:64740739 T/C cg23250157 chr14:64679961 SYNE2 0.53 7.64 0.42 4.09e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6912958 1.000 rs9294380 chr6:88152667 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -7.48 -0.42 1.08e-12 Monocyte percentage of white cells; CESC cis rs7465272 0.530 rs10103161 chr8:143738571 A/G cg10596483 chr8:143751796 JRK 0.42 5.46 0.32 1.11e-7 Bipolar disorder and schizophrenia; CESC cis rs7267979 1.000 rs2257991 chr20:25270339 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.9 -18.95 -0.76 3.38e-51 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19078903 chr1:21112721 HP1BP3 -0.58 -6.4 -0.37 7.03e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01720705 chr1:231175557 FAM89A 0.52 6.11 0.35 3.52e-9 Gut microbiome composition (summer); CESC cis rs875971 0.577 rs34888281 chr7:65585771 C/T cg14393609 chr7:65229607 NA -0.41 -5.3 -0.31 2.45e-7 Aortic root size; CESC cis rs59698941 0.943 rs55767930 chr5:132203952 G/A cg02081065 chr5:132209139 LEAP2 -0.52 -5.12 -0.3 5.8e-7 Apolipoprotein A-IV levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02551604 chr5:131831745 NA 0.55 6.68 0.38 1.4e-10 Gut microbiome composition (summer); CESC cis rs4835473 0.932 rs1877234 chr4:144907927 A/T cg25736465 chr4:144833511 NA 0.41 6.29 0.36 1.28e-9 Immature fraction of reticulocytes; CESC cis rs738322 0.967 rs133013 chr22:38570912 C/T cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC cis rs6580649 1.000 rs3825404 chr12:48399931 A/G cg24011408 chr12:48396354 COL2A1 0.41 5.3 0.31 2.48e-7 Lung cancer; CESC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg24562669 chr7:97807699 LMTK2 0.51 7.53 0.42 7.86e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs9818758 0.505 rs67286839 chr3:49265744 C/T cg00383909 chr3:49044727 WDR6 0.82 6.25 0.36 1.63e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg10295955 chr4:187884368 NA 1.03 17.37 0.73 1.17e-45 Lobe attachment (rater-scored or self-reported); CESC cis rs4900538 0.927 rs1190544 chr14:102903398 G/A cg18135206 chr14:102964638 TECPR2 -0.8 -10.72 -0.55 1.65e-22 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs11718455 0.921 rs1404482 chr3:43997282 A/G cg08738300 chr3:44038990 NA 0.44 5.73 0.33 2.75e-8 Coronary artery disease; CESC trans rs10435719 0.867 rs35778860 chr8:11791338 C/T cg15556689 chr8:8085844 FLJ10661 0.52 6.38 0.36 7.99e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs1144333 0.737 rs1144331 chr1:76272357 G/A cg10523679 chr1:76189770 ACADM -0.57 -5.44 -0.32 1.22e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs7665939 1.000 rs72709206 chr4:190109171 T/C cg09826759 chr4:190284978 NA -0.87 -7.17 -0.4 7.56e-12 Amyotrophic lateral sclerosis; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg27138088 chr11:842605 TSPAN4;POLR2L 0.52 6.78 0.38 7.84e-11 Breast cancer;Type 2 diabetes; CESC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg04369109 chr6:150039330 LATS1 0.38 5.18 0.3 4.46e-7 Lung cancer; CESC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg00149659 chr3:10157352 C3orf10 0.69 7.88 0.44 8.76e-14 Alzheimer's disease; CESC cis rs10752881 1.000 rs6673559 chr1:182983197 G/C ch.1.3577855R chr1:183094577 LAMC1 0.83 13.25 0.63 4.18e-31 Colorectal cancer; CESC cis rs7474896 0.515 rs624359 chr10:38299132 T/C cg25427524 chr10:38739819 LOC399744 0.48 5.48 0.32 9.76e-8 Obesity (extreme); CESC cis rs4722166 0.630 rs13311155 chr7:22789789 A/C cg05265849 chr7:22767390 IL6 0.58 7.39 0.41 1.9e-12 Lung cancer; CESC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.2e-8 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09247696 chr2:74756297 HTRA2;AUP1 -0.56 -6.55 -0.37 2.92e-10 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs6657720 chr1:46386269 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg22535103 chr8:58192502 C8orf71 -1.04 -12.69 -0.61 3.88e-29 Developmental language disorder (linguistic errors); CESC cis rs1215050 0.740 rs6854802 chr4:99065480 A/C cg17366294 chr4:99064904 C4orf37 0.4 5.16 0.3 4.9e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs3733585 0.673 rs7434391 chr4:9967682 C/G cg11266682 chr4:10021025 SLC2A9 -0.58 -10.94 -0.56 3.03e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs853679 0.824 rs1321505 chr6:28052823 A/C cg18032046 chr6:28092343 ZSCAN16 -0.75 -6.28 -0.36 1.36e-9 Depression; CESC cis rs11630290 1.000 rs72750987 chr15:63999112 G/C cg12036633 chr15:63758958 NA -0.56 -5.29 -0.31 2.55e-7 Iris characteristics; CESC cis rs10504073 0.669 rs55948643 chr8:50026403 C/G cg00325661 chr8:49890786 NA 0.52 7.77 0.43 1.7e-13 Blood metabolite ratios; CESC cis rs2235544 0.565 rs635059 chr1:54469120 G/C cg25741118 chr1:54482237 LDLRAD1 0.24 5.76 0.33 2.29e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs7216064 0.589 rs7213585 chr17:66062316 A/T cg07042672 chr17:66097459 LOC651250 -0.66 -8.73 -0.47 2.89e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs12497850 0.863 rs4858799 chr3:48728204 G/C cg06212747 chr3:49208901 KLHDC8B 0.61 8.1 0.45 1.99e-14 Parkinson's disease; CESC cis rs78456975 1.000 rs13397299 chr2:1564222 A/C cg26248373 chr2:1572462 NA -0.53 -5.23 -0.31 3.41e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg03452623 chr4:187889614 NA 0.87 15.47 0.69 6.4e-39 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15697793 chr8:1797445 ARHGEF10 0.45 6.3 0.36 1.2e-9 Fibrinogen levels; CESC cis rs727505 0.607 rs10464674 chr7:124791551 A/G cg23710748 chr7:124431027 NA -0.4 -6.27 -0.36 1.44e-9 Lewy body disease; CESC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.86e-8 Lung cancer; CESC cis rs761746 0.705 rs5994415 chr22:32004588 G/A cg25791279 chr22:32026902 PISD 0.62 7.35 0.41 2.46e-12 Intelligence; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19014323 chr10:43902618 HNRNPF 0.48 6.31 0.36 1.14e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg10494973 chr17:80897199 TBCD -0.48 -6.09 -0.35 3.92e-9 Breast cancer; CESC cis rs11583043 0.575 rs12759611 chr1:101587145 T/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.48 5.33 0.31 2.11e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs13256369 0.802 rs35382339 chr8:8559255 G/A cg17143192 chr8:8559678 CLDN23 0.78 8.72 0.47 3.13e-16 Obesity-related traits; CESC cis rs5753618 0.583 rs34545960 chr22:31812462 G/A cg00478049 chr22:31556069 RNF185 -0.43 -5.11 -0.3 6.22e-7 Colorectal cancer; CESC cis rs8067545 0.611 rs2703800 chr17:20086562 C/T cg13482628 chr17:19912719 NA 0.42 5.45 0.32 1.13e-7 Schizophrenia; CESC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg25405998 chr7:65216604 CCT6P1 0.45 5.06 0.3 7.71e-7 Aortic root size; CESC cis rs589448 0.902 rs315138 chr12:69764850 A/T cg20891283 chr12:69753455 YEATS4 0.98 16.88 0.72 6.73e-44 Cerebrospinal fluid biomarker levels; CESC cis rs7223966 1.000 rs11079511 chr17:61858537 C/G cg11494091 chr17:61959527 GH2 0.38 5.09 0.3 6.85e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2012796 0.956 rs7147254 chr14:81820503 G/A cg02996355 chr14:81879375 NA 0.57 6.82 0.39 6.15e-11 Night sleep phenotypes; CESC cis rs698833 0.886 rs698766 chr2:44574277 C/G cg04920474 chr2:44395004 PPM1B 0.37 5.11 0.3 6.29e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20916237 chr14:105487215 CDCA4 0.56 6.76 0.38 8.8e-11 Gut microbiome composition (summer); CESC cis rs7772486 0.686 rs9376961 chr6:146048737 C/T cg05347473 chr6:146136440 FBXO30 0.52 6.84 0.39 5.42e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7937682 0.575 rs10789851 chr11:111750955 G/C cg09085632 chr11:111637200 PPP2R1B 0.91 12.08 0.6 4.6e-27 Primary sclerosing cholangitis; CESC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg17376030 chr22:41985996 PMM1 0.56 6.22 0.36 1.89e-9 Vitiligo; CESC cis rs7312933 0.737 rs10880261 chr12:42573822 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.22 0.36 1.97e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs561341 0.883 rs886224 chr17:30229902 T/C cg27661571 chr11:113659931 NA -0.67 -6.69 -0.38 1.33e-10 Hip circumference adjusted for BMI; CESC cis rs6732160 0.845 rs6718690 chr2:73387162 C/T cg01422370 chr2:73384389 NA -0.44 -7.64 -0.42 4.02e-13 Intelligence (multi-trait analysis); CESC cis rs12220238 1.000 rs10824096 chr10:75937554 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.58 5.19 0.3 4.22e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs11785400 1.000 rs6997771 chr8:143747752 T/G cg24634471 chr8:143751801 JRK 0.47 6.13 0.35 3.09e-9 Schizophrenia; CESC cis rs7149337 1.000 rs4261445 chr14:51723540 G/A cg23942311 chr14:51606299 NA 0.45 7.55 0.42 6.92e-13 Cancer; CESC cis rs2932538 0.961 rs4839257 chr1:113219388 A/T cg22162597 chr1:113214053 CAPZA1 -0.49 -6.58 -0.37 2.48e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs7100689 0.646 rs1934694 chr10:82125325 G/A cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs2637266 0.539 rs17231884 chr10:78536425 C/T cg06894710 chr10:78142662 C10orf11 -0.38 -5.18 -0.3 4.3e-7 Pulmonary function; CESC cis rs34779708 0.931 rs35848945 chr10:35287561 G/T cg03585969 chr10:35415529 CREM 0.75 9.88 0.52 8.43e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs950776 0.518 rs8053 chr15:78841220 T/C cg06917634 chr15:78832804 PSMA4 -0.75 -11.27 -0.57 2.48e-24 Sudden cardiac arrest; CESC cis rs7617480 0.648 rs7653408 chr3:48972351 A/C cg06212747 chr3:49208901 KLHDC8B 0.48 5.69 0.33 3.29e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg11663144 chr21:46675770 NA -0.62 -9.74 -0.51 2.36e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2262909 0.849 rs10420483 chr19:22190378 A/G cg11619707 chr19:22235551 ZNF257 -0.35 -5.78 -0.33 2.04e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs2070433 0.904 rs8130209 chr21:47925984 T/C cg12379764 chr21:47803548 PCNT 0.5 6.08 0.35 4.26e-9 Lymphocyte counts; CESC cis rs9614461 0.702 rs3788648 chr22:45727180 G/A cg23503501 chr22:45809793 SMC1B;RIBC2 0.69 6.79 0.38 7.5e-11 Tonsillectomy; CESC cis rs6460942 0.915 rs6965564 chr7:12306013 C/T cg02935154 chr7:12443704 VWDE -0.41 -5.61 -0.33 5.05e-8 Coronary artery disease; CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg07092213 chr7:1199455 ZFAND2A -0.49 -5.67 -0.33 3.8e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg17366294 chr4:99064904 C4orf37 0.55 7.43 0.41 1.54e-12 Colonoscopy-negative controls vs population controls; CESC cis rs35306767 0.953 rs1106064 chr10:957211 G/A cg25019033 chr10:957182 NA -0.67 -8.16 -0.45 1.4e-14 Eosinophil percentage of granulocytes; CESC cis rs61542988 0.535 rs10807813 chr7:22829961 C/T cg13679077 chr7:22862647 TOMM7 0.64 7.29 0.41 3.52e-12 Fibrinogen levels; CESC cis rs4835473 0.897 rs36083752 chr4:144614530 T/A cg25736465 chr4:144833511 NA -0.36 -5.45 -0.32 1.17e-7 Immature fraction of reticulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07520141 chr5:10564205 ANKRD33B 0.47 6.09 0.35 3.94e-9 Gut microbiota (bacterial taxa); CESC cis rs2404602 0.669 rs12438540 chr15:76943213 C/G cg26408565 chr15:76604113 ETFA -0.4 -5.68 -0.33 3.45e-8 Blood metabolite levels; CESC cis rs763121 0.853 rs5757204 chr22:39046700 A/C cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs12973672 1.000 rs10421599 chr19:35767933 G/A cg12095397 chr19:35769544 USF2 0.54 7.33 0.41 2.81e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00602891 chr17:80408864 C17orf62 -0.58 -6.42 -0.37 6.09e-10 Gut microbiome composition (summer); CESC cis rs10751667 0.666 rs12295141 chr11:947065 G/A cg20946044 chr11:1010712 AP2A2 -0.38 -5.23 -0.31 3.44e-7 Alzheimer's disease (late onset); CESC cis rs73206853 0.563 rs1107652 chr12:111176213 A/G cg04375036 chr12:111181819 PPP1CC -0.54 -5.21 -0.31 3.71e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg26839252 chr6:160211577 TCP1;MRPL18 0.45 5.29 0.31 2.52e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs6032067 0.929 rs17424868 chr20:43818519 T/G cg10761708 chr20:43804764 PI3 0.53 6.36 0.36 8.83e-10 Blood protein levels; CESC cis rs1775715 0.737 rs1419171 chr10:32214831 C/A cg26784012 chr10:32216390 ARHGAP12 0.39 5.22 0.31 3.7e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9611565 0.559 rs7290991 chr22:41964361 C/G cg06481639 chr22:41940642 POLR3H -0.57 -6.38 -0.36 7.88e-10 Vitiligo; CESC cis rs9487051 0.676 rs13210693 chr6:109598964 A/G cg01475377 chr6:109611718 NA 0.43 6.67 0.38 1.53e-10 Reticulocyte fraction of red cells; CESC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg15105969 chr2:36825350 FEZ2 -0.47 -5.72 -0.33 2.83e-8 Height; CESC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg04944784 chr2:26401820 FAM59B -0.96 -10.55 -0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg21918786 chr6:109611834 NA 0.38 5.47 0.32 1.05e-7 Reticulocyte fraction of red cells; CESC cis rs17818399 0.926 rs13033177 chr2:46831062 C/A cg06386533 chr2:46925753 SOCS5 0.46 5.15 0.3 5e-7 Height; CESC cis rs1577917 0.958 rs10944137 chr6:86454314 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.53 -6.91 -0.39 3.68e-11 Response to antipsychotic treatment; CESC cis rs258892 0.895 rs10052974 chr5:72067869 A/G cg21869765 chr5:72125136 TNPO1 -0.43 -5.35 -0.31 1.93e-7 Small cell lung carcinoma; CESC cis rs3126085 0.935 rs10749669 chr1:152177289 A/C cg03465714 chr1:152285911 FLG 0.46 5.66 0.33 3.95e-8 Atopic dermatitis; CESC cis rs7824557 0.836 rs2736378 chr8:11119760 G/A cg21775007 chr8:11205619 TDH -0.38 -5.68 -0.33 3.46e-8 Retinal vascular caliber; CESC cis rs11853189 0.938 rs75369292 chr15:78555357 T/C cg22935921 chr15:78556834 DNAJA4 0.61 5.18 0.3 4.45e-7 Red cell distribution width; CESC cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg07697082 chr8:82753677 SNX16 0.4 5.62 0.33 4.79e-8 Diastolic blood pressure; CESC cis rs1707322 0.963 rs11211202 chr1:46292382 C/T cg05343316 chr1:45956843 TESK2 0.43 5.35 0.31 1.92e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10883723 0.810 rs2296582 chr10:104244139 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.73 0.43 2.17e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs6728642 0.519 rs72811651 chr2:97572229 G/C cg26665480 chr2:98280029 ACTR1B -0.58 -5.28 -0.31 2.75e-7 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg26516362 chr5:178986906 RUFY1 0.44 7.03 0.4 1.7e-11 Lung cancer; CESC cis rs3796619 1.000 rs1466214 chr4:1073760 C/T cg27284194 chr4:1044797 NA 0.36 5.47 0.32 1.07e-7 Recombination rate (males); CESC cis rs9513627 0.573 rs12431100 chr13:100184918 C/G cg25919922 chr13:100150906 NA -0.76 -8.87 -0.48 1.07e-16 Obesity-related traits; CESC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg04369109 chr6:150039330 LATS1 -0.43 -5.98 -0.35 7.01e-9 Lung cancer; CESC cis rs854765 0.583 rs6502627 chr17:17849671 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC cis rs8070128 0.688 rs59304093 chr17:17875407 A/G cg16928487 chr17:17741425 SREBF1 -0.62 -10.37 -0.54 2.2e-21 Total body bone mineral density; CESC cis rs738322 1.000 rs738320 chr22:38568715 G/T cg25457927 chr22:38595422 NA -0.29 -5.52 -0.32 8.04e-8 Cutaneous nevi; CESC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 10.21 0.53 7.28e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3806933 0.522 rs12522383 chr5:110455266 C/T cg04022379 chr5:110408740 TSLP 0.42 7.06 0.4 1.44e-11 Eosinophilic esophagitis; CESC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs2637266 0.756 rs2583064 chr10:78557708 A/G cg18941641 chr10:78392320 NA 0.41 7.83 0.43 1.17e-13 Pulmonary function; CESC cis rs7089973 0.872 rs3180654 chr10:116615045 T/C cg25233709 chr10:116636983 FAM160B1 0.35 5.08 0.3 7.02e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.4 0.37 7.04e-10 Prudent dietary pattern; CESC cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg14440974 chr22:39074834 NA -0.42 -5.66 -0.33 3.87e-8 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01446372 chr21:30365398 RNF160 -0.43 -6.04 -0.35 5.25e-9 Gambling; CESC trans rs12599106 0.715 rs34006830 chr16:34878550 C/A cg05064044 chr6:292385 DUSP22 -0.66 -8.09 -0.45 2.11e-14 Menopause (age at onset); CESC cis rs4919087 1.000 rs4919090 chr10:99088419 C/G cg25902810 chr10:99078978 FRAT1 -0.66 -8.57 -0.47 8.6e-16 Monocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10490227 chr1:40348903 TRIT1 -0.44 -6.34 -0.36 9.93e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19070139 chr6:42928517 GNMT 0.53 6.25 0.36 1.59e-9 Gut microbiome composition (summer); CESC cis rs938554 0.744 rs6449137 chr4:9932479 A/T cg00071950 chr4:10020882 SLC2A9 -0.44 -5.96 -0.34 8.01e-9 Blood metabolite levels; CESC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg04944784 chr2:26401820 FAM59B -0.66 -7.53 -0.42 7.95e-13 Gut microbiome composition (summer); CESC cis rs28830936 1.000 rs11637341 chr15:41955825 G/T cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.37 -5.32 -0.31 2.16e-7 Diastolic blood pressure; CESC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg02951883 chr7:2050386 MAD1L1 0.43 5.6 0.33 5.33e-8 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02120071 chr2:114737129 NA -0.57 -6.17 -0.35 2.52e-9 Gut microbiome composition (summer); CESC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg07395648 chr5:131743802 NA 0.4 5.19 0.3 4.19e-7 Breast cancer; CESC cis rs8067354 0.574 rs2531899 chr17:58007193 A/G cg13753209 chr17:57696993 CLTC -0.55 -5.92 -0.34 1.01e-8 Hemoglobin concentration; CESC cis rs5769765 0.632 rs13056783 chr22:50259152 A/T cg02269571 chr22:50332266 NA 0.49 6.57 0.37 2.65e-10 Schizophrenia; CESC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.79 9.65 0.51 4.49e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs11252926 0.604 rs12359454 chr10:568081 T/C cg08603382 chr10:743973 NA -0.47 -6.37 -0.36 8.16e-10 Psychosis in Alzheimer's disease; CESC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 -1.03 -11.14 -0.56 6.96e-24 Platelet count; CESC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6963495 0.818 rs73192120 chr7:105171156 C/T cg13798780 chr7:105162888 PUS7 0.77 7.88 0.44 8.3e-14 Bipolar disorder (body mass index interaction); CESC cis rs2274273 1.000 rs2075603 chr14:55609955 C/A cg04306507 chr14:55594613 LGALS3 0.28 5.19 0.3 4.11e-7 Protein biomarker; CESC cis rs7666738 0.830 rs17026973 chr4:98680041 T/A cg17366294 chr4:99064904 C4orf37 0.56 7.61 0.42 4.87e-13 Colonoscopy-negative controls vs population controls; CESC cis rs10129255 0.500 rs12101190 chr14:107192386 C/T cg07958169 chr14:107095056 NA -0.54 -8.32 -0.45 4.77e-15 Kawasaki disease; CESC cis rs4604732 0.631 rs35046441 chr1:247626812 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11785400 0.642 rs4256574 chr8:143725705 C/T cg10596483 chr8:143751796 JRK 0.42 5.36 0.31 1.77e-7 Schizophrenia; CESC cis rs6570726 0.967 rs403584 chr6:145807010 G/A cg23711669 chr6:146136114 FBXO30 0.74 10.9 0.56 4.34e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs6912958 0.781 rs9444519 chr6:88290398 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.58 -0.37 2.55e-10 Monocyte percentage of white cells; CESC cis rs4727027 0.899 rs11771339 chr7:148854132 A/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.92 -0.39 3.45e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2070488 0.804 rs2276541 chr3:38512779 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 13.24 0.63 4.69e-31 Electrocardiographic conduction measures; CESC cis rs7264396 0.563 rs78084033 chr20:34219990 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.92 -10.16 -0.53 1.07e-20 Total cholesterol levels; CESC cis rs13385 0.769 rs10045510 chr5:139613188 T/C cg26211634 chr5:139558579 C5orf32 0.48 5.29 0.31 2.59e-7 Atrial fibrillation; CESC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg04267008 chr7:1944627 MAD1L1 -0.57 -6.78 -0.38 7.96e-11 Bipolar disorder and schizophrenia; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg21939482 chr7:6388130 C7orf70 0.49 6.05 0.35 4.88e-9 Thyroid stimulating hormone; CESC cis rs3091242 0.933 rs35148262 chr1:25766623 A/G cg27572855 chr1:25598939 RHD 0.5 8.53 0.46 1.12e-15 Erythrocyte sedimentation rate; CESC cis rs2708240 1.000 rs759179 chr7:147574914 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.23e-8 QT interval (drug interaction); CESC cis rs7223966 0.960 rs11659013 chr17:61869559 C/G cg11494091 chr17:61959527 GH2 0.38 5.17 0.3 4.56e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs8031584 0.958 rs34909055 chr15:31284170 C/T cg14829155 chr15:31115871 NA -0.64 -8.34 -0.46 3.98e-15 Huntington's disease progression; CESC cis rs10504229 0.516 rs1866994 chr8:57990092 A/C cg22535103 chr8:58192502 C8orf71 -0.48 -5.89 -0.34 1.16e-8 Developmental language disorder (linguistic errors); CESC cis rs225245 0.782 rs225293 chr17:33925906 A/G cg05299278 chr17:33885742 SLFN14 0.37 5.39 0.31 1.6e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs12136530 0.774 rs2088828 chr1:19757646 C/A cg01832549 chr1:19774989 CAPZB -0.48 -6.74 -0.38 1.01e-10 Lead levels in blood; CESC cis rs7617773 0.780 rs13090538 chr3:48370769 A/C cg11946769 chr3:48343235 NME6 0.85 11.68 0.58 1.06e-25 Coronary artery disease; CESC cis rs1448094 0.645 rs8181635 chr12:86465136 C/T cg02569458 chr12:86230093 RASSF9 -0.38 -5.49 -0.32 9.47e-8 Major depressive disorder; CESC cis rs2281558 0.837 rs56238023 chr20:25516947 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.55 7.62 0.42 4.5e-13 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs8050907 0.744 rs9938647 chr16:4572151 A/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.72 5.17 0.3 4.53e-7 Obesity-related traits; CESC cis rs523522 0.962 rs7136951 chr12:120941927 C/T cg12219531 chr12:120966889 COQ5 0.75 9.95 0.52 5.02e-20 High light scatter reticulocyte count; CESC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg17724175 chr1:150552817 MCL1 0.33 5.08 0.3 7.16e-7 Melanoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24043861 chr14:73396628 DCAF4 -0.61 -7.09 -0.4 1.19e-11 Gut microbiome composition (summer); CESC cis rs12586317 0.547 rs60152856 chr14:35421373 G/A cg05294307 chr14:35346193 BAZ1A -0.5 -5.36 -0.31 1.77e-7 Psoriasis; CESC cis rs7762018 1.000 rs6923339 chr6:170128033 T/A cg05834625 chr6:170176447 C6orf70 0.66 7.76 0.43 1.9e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.41e-28 Prudent dietary pattern; CESC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg21770322 chr7:97807741 LMTK2 0.55 8.27 0.45 6.54e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs910316 1.000 rs1043674 chr14:75549370 T/C cg11812906 chr14:75593930 NEK9 0.91 15.48 0.69 6.13e-39 Height; CESC cis rs2997447 0.706 rs61776622 chr1:26469035 A/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.41 0.32 1.44e-7 QRS complex (12-leadsum); CESC cis rs7246657 0.943 rs7255972 chr19:37933841 T/C cg23950597 chr19:37808831 NA -0.61 -6.23 -0.36 1.85e-9 Coronary artery calcification; CESC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs1801251 1.000 rs35212961 chr2:233582762 C/T cg08000102 chr2:233561755 GIGYF2 0.69 9.14 0.49 1.67e-17 Coronary artery disease; CESC cis rs2439831 0.850 rs28858500 chr15:44156942 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.69 0.33 3.28e-8 Lung cancer in ever smokers; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg04319097 chr18:5293279 ZFP161 0.42 6.2 0.36 2.15e-9 Prevalent atrial fibrillation; CESC cis rs9309473 0.519 rs2421670 chr2:73886661 T/G cg20560298 chr2:73613845 ALMS1 0.51 7.16 0.4 8.01e-12 Metabolite levels; CESC cis rs9303280 0.742 rs11557466 chr17:38024626 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.41 -0.32 1.42e-7 Self-reported allergy; CESC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg22535103 chr8:58192502 C8orf71 -0.84 -9.44 -0.5 2.04e-18 Developmental language disorder (linguistic errors); CESC cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg05234568 chr11:5960015 NA -0.41 -5.18 -0.3 4.5e-7 DNA methylation (variation); CESC cis rs6088590 1.000 rs6087632 chr20:33407704 A/C cg24642439 chr20:33292090 TP53INP2 0.84 11.62 0.58 1.67e-25 Coronary artery disease; CESC cis rs7923609 0.936 rs10822160 chr10:65112796 T/G cg01631684 chr10:65280961 REEP3 -0.42 -5.15 -0.3 5.01e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs12912251 1.000 rs34356257 chr15:38989605 T/C cg01338139 chr15:38987640 C15orf53 -0.46 -5.27 -0.31 2.89e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs1620921 0.505 rs11758404 chr6:161210455 A/G cg01280913 chr6:161186852 NA -0.38 -5.43 -0.32 1.28e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs2929278 0.561 rs2927071 chr15:43919081 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.52 6.67 0.38 1.51e-10 Schizophrenia; CESC cis rs9911578 1.000 rs4482353 chr17:56896834 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.58 0.69 2.71e-39 Intelligence (multi-trait analysis); CESC cis rs6540556 0.723 rs12086634 chr1:209880259 T/G cg05527609 chr1:210001259 C1orf107 -0.75 -7.97 -0.44 4.84e-14 Red blood cell count; CESC cis rs6087990 0.966 rs1883730 chr20:31337487 T/A cg13636640 chr20:31349939 DNMT3B 0.92 16.62 0.71 5.42e-43 Ulcerative colitis; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19575883 chr2:172231724 METTL8 -0.45 -6.03 -0.35 5.49e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1023500 0.551 rs2301521 chr22:42423110 G/C cg15557168 chr22:42548783 NA -0.39 -5.16 -0.3 4.79e-7 Schizophrenia; CESC cis rs9902453 0.765 rs3102562 chr17:28040403 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.16 0.53 1.05e-20 Coffee consumption (cups per day); CESC cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg03676636 chr4:99064102 C4orf37 0.33 5.13 0.3 5.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3820928 0.839 rs58580037 chr2:227876274 G/T cg05526886 chr2:227700861 RHBDD1 -0.46 -5.68 -0.33 3.52e-8 Pulmonary function; CESC cis rs12995491 0.843 rs1878809 chr2:88518315 C/T cg04511125 chr2:88470314 THNSL2 -0.53 -7.46 -0.42 1.26e-12 Response to metformin (IC50); CESC cis rs35955747 0.902 rs2413048 chr22:31686102 G/A cg25791279 chr22:32026902 PISD -0.5 -5.99 -0.35 6.9e-9 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg07701084 chr6:150067640 NUP43 0.43 6.0 0.35 6.52e-9 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23660064 chr1:223395288 SUSD4 -0.61 -6.81 -0.39 6.6e-11 Gut microbiome composition (summer); CESC cis rs9911578 0.757 rs4793954 chr17:56629527 G/T cg05425664 chr17:57184151 TRIM37 0.47 5.54 0.32 7.12e-8 Intelligence (multi-trait analysis); CESC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg26119090 chr2:26468346 HADHA;HADHB 0.81 8.77 0.47 2.26e-16 Gut microbiome composition (summer); CESC cis rs7116495 0.786 rs678193 chr11:71770273 A/C cg26138937 chr11:71823887 C11orf51 -0.83 -6.95 -0.39 2.81e-11 Severe influenza A (H1N1) infection; CESC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg05564831 chr3:52568323 NT5DC2 0.45 6.97 0.39 2.55e-11 Bipolar disorder; CESC cis rs2637266 0.935 rs6480822 chr10:78354092 A/C cg18941641 chr10:78392320 NA 0.44 8.21 0.45 9.93e-15 Pulmonary function; CESC trans rs4756846 1.000 rs56030154 chr11:16400608 C/T cg05579622 chr5:10618622 ANKRD33B 0.76 6.93 0.39 3.14e-11 Obesity and osteoporosis; CESC cis rs10242455 0.702 rs3528 chr7:99055940 T/C cg18809830 chr7:99032528 PTCD1 -0.61 -5.24 -0.31 3.28e-7 Blood metabolite levels; CESC cis rs6570726 0.764 rs9403726 chr6:145901686 G/T cg05347473 chr6:146136440 FBXO30 0.53 6.98 0.39 2.33e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg27297192 chr10:134578999 INPP5A 0.38 5.16 0.3 4.81e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs5769765 0.954 rs6009900 chr22:50236610 T/C cg02269571 chr22:50332266 NA -0.46 -5.94 -0.34 8.76e-9 Schizophrenia; CESC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg21433313 chr16:3507492 NAT15 0.51 8.54 0.46 1.1e-15 Tuberculosis; CESC cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg24818145 chr4:99064322 C4orf37 0.39 5.1 0.3 6.52e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27468401 chr16:70285408 EXOSC6 0.56 6.3 0.36 1.23e-9 Gut microbiome composition (summer); CESC cis rs4689388 0.824 rs114669221 chr4:6301459 G/A cg14416269 chr4:6271139 WFS1 0.47 8.02 0.44 3.4e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4844614 0.951 rs17049197 chr1:207874704 G/A cg21110645 chr1:207815933 NA 0.35 5.21 0.3 3.75e-7 LDL cholesterol; CESC cis rs56104184 0.723 rs73063524 chr19:49409004 T/C cg15549821 chr19:49342101 PLEKHA4 -0.53 -5.47 -0.32 1.06e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs9527 0.637 rs7096169 chr10:104618695 A/G cg04362960 chr10:104952993 NT5C2 0.5 6.12 0.35 3.44e-9 Arsenic metabolism; CESC cis rs7336332 0.511 rs7998978 chr13:27999457 T/C cg22138327 chr13:27999177 GTF3A 0.86 9.68 0.51 3.52e-19 Weight; CESC cis rs4561483 0.583 rs1019813 chr16:11940829 C/T cg08843971 chr16:11963173 GSPT1 0.45 6.22 0.36 1.93e-9 Testicular germ cell tumor; CESC cis rs1545257 0.505 rs67786999 chr2:24637160 T/G cg06627628 chr2:24431161 ITSN2 -0.5 -6.02 -0.35 5.7e-9 Sjögren's syndrome; CESC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.59 0.64 2.86e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1707322 1.000 rs6672115 chr1:46272879 T/C cg05343316 chr1:45956843 TESK2 0.49 5.92 0.34 9.91e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg08470875 chr2:26401718 FAM59B -0.46 -5.11 -0.3 6.17e-7 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs10939746 chr4:17684951 A/G cg16339924 chr4:17578868 LAP3 -0.49 -6.23 -0.36 1.8e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs6084875 0.641 rs6052807 chr20:4721910 G/A cg10192164 chr16:30419175 ZNF771 -0.51 -6.15 -0.35 2.78e-9 Systemic lupus erythematosus; CESC cis rs9291683 0.526 rs12506122 chr4:10033538 C/A cg02734326 chr4:10020555 SLC2A9 0.45 6.14 0.35 3.04e-9 Bone mineral density; CESC cis rs28489187 0.706 rs233120 chr1:85788490 A/C cg16011679 chr1:85725395 C1orf52 0.48 5.65 0.33 4.16e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs7680126 0.500 rs4697935 chr4:10149593 C/T cg11266682 chr4:10021025 SLC2A9 -0.5 -6.48 -0.37 4.35e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs17039065 0.920 rs9790677 chr4:109443588 G/T cg16022748 chr4:109541635 LOC285456;RPL34 0.64 5.8 0.34 1.93e-8 Gut microbiome composition (summer); CESC cis rs13253111 0.624 rs1979329 chr8:28096772 C/G cg26534493 chr8:28060551 NA 0.48 7.52 0.42 8.73e-13 Childhood body mass index; CESC cis rs7617773 0.780 rs2541 chr3:48339618 A/G cg11946769 chr3:48343235 NME6 0.89 12.11 0.6 3.63e-27 Coronary artery disease; CESC cis rs12121840 0.607 rs285435 chr1:165518480 G/A cg16553119 chr1:165599451 MGST3 0.48 5.9 0.34 1.12e-8 Interleukin-1-receptor antagonist levels; CESC cis rs4728302 0.869 rs11770927 chr7:133593126 G/A cg10665199 chr7:133106180 EXOC4 0.38 5.33 0.31 2.05e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs523522 0.847 rs11065132 chr12:120908459 C/T cg27279351 chr12:120934652 DYNLL1 0.68 8.74 0.47 2.65e-16 High light scatter reticulocyte count; CESC cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg02297831 chr4:17616191 MED28 -0.55 -6.57 -0.37 2.63e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg02018176 chr4:1364513 KIAA1530 0.47 6.23 0.36 1.85e-9 Longevity; CESC trans rs1814175 0.645 rs28454367 chr11:50045708 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.71 -0.75 2.23e-50 Height; CESC cis rs2228479 0.850 rs11649162 chr16:89807131 C/A cg06558623 chr16:89946397 TCF25 1.15 9.26 0.49 7.46e-18 Skin colour saturation; CESC cis rs7216064 0.906 rs7223643 chr17:65830282 A/G cg12091567 chr17:66097778 LOC651250 -0.8 -8.82 -0.48 1.62e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7223966 1.000 rs9908044 chr17:61747032 A/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.6 -0.33 5.23e-8 Hip circumference adjusted for BMI;Body mass index; CESC trans rs10448044 0.750 rs10448045 chr8:80103537 G/C cg08211306 chr6:46097784 ENPP4 0.45 6.32 0.36 1.08e-9 Suicide in bipolar disorder; CESC cis rs4595586 0.545 rs1839402 chr12:39371615 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.6 0.42 5e-13 Morning vs. evening chronotype; CESC cis rs453301 0.658 rs12114954 chr8:8904862 T/G cg06636001 chr8:8085503 FLJ10661 -0.43 -5.3 -0.31 2.42e-7 Joint mobility (Beighton score); CESC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.07e-8 Lung cancer; CESC cis rs2050392 0.517 rs687036 chr10:30761249 G/A cg18806716 chr10:30721971 MAP3K8 -0.54 -8.38 -0.46 3.19e-15 Inflammatory bowel disease; CESC cis rs1023500 0.596 rs133350 chr22:42429049 A/G cg04733989 chr22:42467013 NAGA 0.79 11.0 0.56 1.9e-23 Schizophrenia; CESC cis rs3820068 0.705 rs72645804 chr1:15868387 A/C cg18192808 chr1:15853278 DNAJC16 0.46 5.44 0.32 1.2e-7 Systolic blood pressure; CESC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.86 14.38 0.66 4.63e-35 Menarche (age at onset); CESC cis rs12887734 0.524 rs722637 chr14:104261723 G/T cg01849466 chr14:104193079 ZFYVE21 0.43 5.65 0.33 4.16e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg02935154 chr7:12443704 VWDE -0.58 -6.25 -0.36 1.67e-9 Coronary artery disease; CESC trans rs208520 0.526 rs7771233 chr6:66819784 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -22.37 -0.81 5.49e-63 Exhaled nitric oxide output; CESC cis rs8141529 0.748 rs5762881 chr22:29289346 C/A cg02153584 chr22:29168773 CCDC117 0.59 7.84 0.43 1.09e-13 Lymphocyte counts; CESC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg22968622 chr17:43663579 NA -0.76 -9.96 -0.52 4.68e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1448094 0.802 rs11513957 chr12:86435551 C/T cg02569458 chr12:86230093 RASSF9 0.4 5.82 0.34 1.69e-8 Major depressive disorder; CESC cis rs3105593 1.000 rs3109894 chr15:50878574 C/T cg08437265 chr15:50716283 USP8 0.45 5.89 0.34 1.19e-8 QT interval; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg22515636 chr2:109150313 NA 0.51 6.73 0.38 1.05e-10 Weight; CESC cis rs9318086 0.648 rs35449605 chr13:24472582 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.44 6.27 0.36 1.46e-9 Myopia (pathological); CESC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg24562669 chr7:97807699 LMTK2 0.49 7.17 0.4 7.48e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs4950322 0.515 rs76327075 chr1:146717973 C/T cg16700924 chr1:146552102 NA -0.39 -5.1 -0.3 6.63e-7 Protein quantitative trait loci; CESC trans rs17685 0.725 rs7795291 chr7:75725206 C/A cg19862616 chr7:65841803 NCRNA00174 0.83 11.96 0.59 1.23e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg05332525 chr7:65337924 VKORC1L1 -0.49 -6.03 -0.35 5.48e-9 Aortic root size; CESC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg16680214 chr1:154839983 KCNN3 -0.45 -6.94 -0.39 2.95e-11 Prostate cancer; CESC cis rs12325245 0.536 rs12924708 chr16:58567643 G/A cg01152986 chr16:58549298 SETD6 0.89 5.4 0.32 1.45e-7 Schizophrenia; CESC cis rs8060686 0.516 rs8059575 chr16:68272635 C/G cg26727032 chr16:67993705 SLC12A4 -0.56 -7.54 -0.42 7.64e-13 HDL cholesterol;Metabolic syndrome; CESC cis rs2777491 1.000 rs2730055 chr15:41735708 C/A cg20272979 chr15:41787780 ITPKA 0.45 6.71 0.38 1.15e-10 Ulcerative colitis; CESC cis rs10463316 0.855 rs352701 chr5:150736474 A/G cg03212797 chr5:150827313 SLC36A1 -0.53 -6.78 -0.38 7.74e-11 Metabolite levels (Pyroglutamine); CESC cis rs727505 0.954 rs1014163 chr7:124443604 G/A cg23710748 chr7:124431027 NA -0.45 -7.05 -0.4 1.55e-11 Lewy body disease; CESC cis rs1008375 1.000 rs62295634 chr4:17685346 C/A cg02297831 chr4:17616191 MED28 0.42 5.29 0.31 2.52e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg17226575 chr8:90914282 OSGIN2 0.48 6.12 0.35 3.43e-9 Tetralogy of Fallot; CESC cis rs9875589 0.915 rs13097822 chr3:13969396 T/A cg19554555 chr3:13937349 NA 0.53 6.68 0.38 1.36e-10 Ovarian reserve; CESC cis rs2279817 0.743 rs12023874 chr1:18025612 A/G cg21791023 chr1:18019539 ARHGEF10L 0.54 7.88 0.44 8.25e-14 Neuroticism; CESC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg23048001 chr7:2026167 MAD1L1 0.45 5.77 0.33 2.17e-8 Schizophrenia; CESC cis rs11190604 1.000 rs7078799 chr10:102301447 G/A cg07080220 chr10:102295463 HIF1AN 0.66 6.04 0.35 5.08e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg09177884 chr7:1199841 ZFAND2A -0.47 -5.92 -0.34 9.69e-9 Longevity;Endometriosis; CESC cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg05863683 chr7:1912471 MAD1L1 0.38 5.54 0.32 7.16e-8 Schizophrenia; CESC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg05585544 chr11:47624801 NA 0.47 6.95 0.39 2.88e-11 Subjective well-being; CESC trans rs1814175 0.558 rs5025146 chr11:49795724 C/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.19 -0.36 2.29e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21871583 chr3:15374148 SH3BP5 0.59 7.23 0.41 5.04e-12 Gut microbiome composition (summer); CESC cis rs2274273 1.000 rs66871576 chr14:55629050 C/T cg04306507 chr14:55594613 LGALS3 0.29 5.33 0.31 2.13e-7 Protein biomarker; CESC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg08470875 chr2:26401718 FAM59B -0.49 -5.29 -0.31 2.54e-7 Gut microbiome composition (summer); CESC cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg18850127 chr7:39170497 POU6F2 0.39 5.51 0.32 8.38e-8 IgG glycosylation; CESC cis rs9287719 0.967 rs7592691 chr2:10737426 A/G cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs3008870 0.959 rs2985808 chr1:67367741 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.01 13.55 0.64 3.74e-32 Lymphocyte percentage of white cells; CESC cis rs4253772 0.591 rs6007747 chr22:46657261 A/G cg09491104 chr22:46646882 C22orf40 -0.63 -9.79 -0.52 1.56e-19 LDL cholesterol;Cholesterol, total; CESC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg02807482 chr3:125708958 NA -0.39 -5.11 -0.3 6.29e-7 Blood pressure (smoking interaction); CESC cis rs35110281 0.837 rs2838340 chr21:45076373 A/G cg01579765 chr21:45077557 HSF2BP -0.5 -8.53 -0.46 1.12e-15 Mean corpuscular volume; CESC cis rs7617480 0.648 rs6806356 chr3:48727636 G/A cg07636037 chr3:49044803 WDR6 0.76 9.49 0.5 1.37e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs1355223 0.506 rs1509660 chr11:34865017 A/G cg11622362 chr11:34938112 PDHX;APIP 0.44 5.29 0.31 2.52e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7560272 0.723 rs2421548 chr2:73641240 A/G cg20560298 chr2:73613845 ALMS1 0.5 7.17 0.4 7.57e-12 Schizophrenia; CESC cis rs10838687 0.736 rs11039148 chr11:47274126 T/A cg25783544 chr11:47291846 MADD 0.54 6.13 0.35 3.09e-9 Proinsulin levels; CESC trans rs931555 0.750 rs11567705 chr5:35861152 C/G cg11740570 chr11:1032135 MUC6 -0.42 -6.02 -0.35 5.84e-9 Multiple sclerosis; CESC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg05368731 chr17:41323189 NBR1 0.79 10.65 0.55 2.72e-22 Menopause (age at onset); CESC trans rs5756813 0.727 rs13055462 chr22:38184685 A/G cg19894588 chr14:64061835 NA -0.64 -8.24 -0.45 7.83e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg00149659 chr3:10157352 C3orf10 0.53 6.77 0.38 8.43e-11 Alzheimer's disease; CESC cis rs4253772 0.550 rs9615953 chr22:46731024 C/G cg18190219 chr22:46762943 CELSR1 -0.64 -5.89 -0.34 1.18e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg05283184 chr6:79620031 NA -0.42 -6.49 -0.37 4.09e-10 Intelligence (multi-trait analysis); CESC cis rs4481887 0.893 rs4529743 chr1:248473683 G/C cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs6901004 0.685 rs354550 chr6:111546484 G/A cg15721981 chr6:111408429 SLC16A10 -0.35 -5.19 -0.3 4.13e-7 Blood metabolite levels; CESC cis rs1348850 0.567 rs4144276 chr2:178523420 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 6.81 0.39 6.35e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg13798912 chr7:905769 UNC84A 0.6 5.92 0.34 9.72e-9 Cerebrospinal P-tau181p levels; CESC cis rs9402673 0.558 rs9688342 chr6:135323026 A/T cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Reticulocyte count;High light scatter reticulocyte count; CESC cis rs3820068 0.705 rs11587541 chr1:15899478 T/C cg17385448 chr1:15911702 AGMAT 0.37 5.78 0.33 2.12e-8 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18354742 chr19:38755139 SPINT2 0.53 6.13 0.35 3.14e-9 Gut microbiome composition (summer); CESC cis rs1784581 0.802 rs9458430 chr6:162426517 G/T cg17173639 chr6:162384350 PARK2 -0.59 -9.0 -0.48 4.42e-17 Itch intensity from mosquito bite; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00482248 chr7:73589137 EIF4H -0.47 -6.29 -0.36 1.33e-9 Asthma; CESC cis rs3858526 0.755 rs10769368 chr11:5962084 C/T cg05234568 chr11:5960015 NA 0.42 5.23 0.31 3.39e-7 DNA methylation (variation); CESC cis rs2637266 0.783 rs846645 chr10:78516000 A/G cg18941641 chr10:78392320 NA 0.43 8.42 0.46 2.39e-15 Pulmonary function; CESC cis rs7927771 0.524 rs7933896 chr11:47882782 C/T cg18512352 chr11:47633146 NA 0.35 5.43 0.32 1.29e-7 Subjective well-being; CESC cis rs12282928 0.743 rs1109906 chr11:48284033 C/T cg26585981 chr11:48327164 OR4S1 -0.36 -5.05 -0.3 8.36e-7 Migraine - clinic-based; CESC cis rs58688157 0.705 rs12421646 chr11:578844 C/G cg02461776 chr11:598696 PHRF1 0.51 5.6 0.33 5.41e-8 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs820218 0.717 rs729778 chr17:73642281 C/T cg01592526 chr17:73663357 RECQL5;SAP30BP -0.38 -5.1 -0.3 6.49e-7 Rotator cuff tears; CESC cis rs9916302 0.904 rs1619021 chr17:37739274 G/A cg00129232 chr17:37814104 STARD3 -0.64 -8.27 -0.45 6.73e-15 Glomerular filtration rate (creatinine); CESC cis rs7107174 1.000 rs7112234 chr11:78102470 G/A cg02023728 chr11:77925099 USP35 0.4 5.56 0.32 6.61e-8 Testicular germ cell tumor; CESC cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg08109568 chr15:31115862 NA -0.69 -9.13 -0.49 1.79e-17 Huntington's disease progression; CESC cis rs7551222 0.752 rs10793766 chr1:204549496 C/T cg20240347 chr1:204465584 NA -0.29 -5.85 -0.34 1.47e-8 Schizophrenia; CESC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg27170947 chr2:26402098 FAM59B 0.87 9.89 0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs5167 0.583 rs7252480 chr19:45458925 C/T cg13119609 chr19:45449297 APOC2 0.38 5.35 0.31 1.89e-7 Blood protein levels; CESC cis rs2288912 0.807 rs3760626 chr19:45457105 A/G cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.51e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs16867321 0.580 rs2049710 chr2:181587276 G/A cg23363182 chr2:181467187 NA 0.44 6.59 0.38 2.32e-10 Obesity; CESC cis rs1538970 0.816 rs11211124 chr1:45962409 T/C cg05343316 chr1:45956843 TESK2 0.93 12.78 0.62 1.91e-29 Platelet count; CESC cis rs9300255 0.596 rs10773002 chr12:123746961 A/T cg05973401 chr12:123451056 ABCB9 -0.46 -5.59 -0.32 5.52e-8 Neutrophil percentage of white cells; CESC cis rs911555 0.755 rs8010247 chr14:103933556 A/G cg24130564 chr14:104152367 KLC1 0.48 6.26 0.36 1.53e-9 Intelligence (multi-trait analysis); CESC cis rs116988415 0.584 rs747858 chr14:65239772 G/A cg25083366 chr14:65239357 SPTB 0.73 5.47 0.32 1.04e-7 Daytime sleep phenotypes; CESC cis rs854765 0.647 rs62073573 chr17:17976354 G/A cg04398451 chr17:18023971 MYO15A -0.78 -11.44 -0.58 6.57e-25 Total body bone mineral density; CESC cis rs7940866 0.801 rs2113928 chr11:130835975 A/G cg12179176 chr11:130786555 SNX19 0.67 10.08 0.53 1.91e-20 Schizophrenia; CESC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg11764359 chr7:65958608 NA 0.82 9.91 0.52 6.84e-20 Aortic root size; CESC cis rs11098499 0.780 rs7680914 chr4:120563053 A/G cg24375607 chr4:120327624 NA 0.44 5.38 0.31 1.65e-7 Corneal astigmatism; CESC cis rs12586317 0.547 rs114371385 chr14:35503724 G/A cg16230307 chr14:35515116 FAM177A1 0.99 10.61 0.55 3.72e-22 Psoriasis; CESC cis rs11718455 0.960 rs13082990 chr3:44005172 T/C cg08738300 chr3:44038990 NA 0.46 6.12 0.35 3.34e-9 Coronary artery disease; CESC cis rs6460942 0.597 rs4719315 chr7:12528634 A/G cg02935154 chr7:12443704 VWDE -0.55 -5.58 -0.32 6.01e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16562251 chr1:166845621 TADA1 0.69 7.6 0.42 5.2e-13 Gut microbiome composition (summer); CESC cis rs13242816 0.892 rs34205980 chr7:116078406 T/A cg04696780 chr7:116139425 CAV2 -0.65 -5.7 -0.33 3.2e-8 P wave duration; CESC cis rs6089584 1.000 rs6089583 chr20:60563624 G/A cg24733560 chr20:60626293 TAF4 0.4 5.77 0.33 2.23e-8 Body mass index; CESC cis rs17818399 0.547 rs35178974 chr2:46763898 T/C cg02822958 chr2:46747628 ATP6V1E2 0.44 5.16 0.3 4.93e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02847760 chr15:40453199 BUB1B 0.57 6.48 0.37 4.55e-10 Gut microbiome composition (summer); CESC cis rs919433 0.662 rs2043018 chr2:198236958 G/A cg03934865 chr2:198174659 NA 0.44 6.27 0.36 1.49e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs12586317 0.531 rs57856432 chr14:35719708 G/T cg16230307 chr14:35515116 FAM177A1 0.41 5.13 0.3 5.54e-7 Psoriasis; CESC cis rs10479542 0.503 rs12719865 chr5:178993566 C/T cg00080972 chr5:178986291 RUFY1 0.47 7.44 0.42 1.41e-12 Lung cancer; CESC cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg18180107 chr4:99064573 C4orf37 0.39 5.09 0.3 6.72e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2832191 0.720 rs7277028 chr21:30494604 T/C cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.63e-20 Dental caries; CESC cis rs10208940 0.920 rs6742045 chr2:68811850 G/A cg12452813 chr2:68675892 NA 0.53 5.29 0.31 2.54e-7 Urate levels in lean individuals; CESC cis rs858239 1.000 rs156425 chr7:23309119 C/T cg23682824 chr7:23144976 KLHL7 -0.42 -5.61 -0.33 4.98e-8 Cerebrospinal fluid biomarker levels; CESC cis rs3733585 0.699 rs6449172 chr4:9966036 A/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.82 -0.59 3.44e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2243480 1.000 rs58062456 chr7:65394852 G/T cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC cis rs72781680 0.898 rs72780118 chr2:23994431 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs12971120 0.891 rs2278159 chr18:72178161 T/C cg25817165 chr18:72167213 CNDP2 -0.61 -7.36 -0.41 2.37e-12 Refractive error; CESC cis rs9457247 0.740 rs13195812 chr6:167443902 C/T cg23791538 chr6:167370224 RNASET2 -0.54 -7.26 -0.41 4.19e-12 Crohn's disease; CESC cis rs1568889 1.000 rs7945367 chr11:28166272 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.98 0.56 2.37e-23 Bipolar disorder; CESC cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.7 6.6 0.38 2.24e-10 Lung function (FEV1/FVC); CESC cis rs2066819 0.892 rs2066807 chr12:56740682 C/G cg26714650 chr12:56694279 CS -1.39 -9.17 -0.49 1.33e-17 Psoriasis vulgaris; CESC cis rs2066819 1.000 rs78149779 chr12:56694817 A/G cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg09177884 chr7:1199841 ZFAND2A -0.55 -6.22 -0.36 1.92e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2637266 0.935 rs2579751 chr10:78339890 G/A cg18941641 chr10:78392320 NA 0.41 7.64 0.42 4.06e-13 Pulmonary function; CESC trans rs7672847 0.547 rs58180406 chr4:170413285 G/A cg19308436 chr1:237949471 RYR2 0.63 6.83 0.39 5.75e-11 Subjective well-being; CESC cis rs6087990 0.735 rs6057647 chr20:31381690 A/T cg13636640 chr20:31349939 DNMT3B 0.81 12.91 0.62 6.32e-30 Ulcerative colitis; CESC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg12311346 chr5:56204834 C5orf35 -0.74 -8.87 -0.48 1.09e-16 Initial pursuit acceleration; CESC cis rs9611519 1.000 rs9611505 chr22:41540279 T/C cg03806693 chr22:41940476 POLR3H -0.58 -5.98 -0.34 7.18e-9 Neuroticism; CESC cis rs7582720 1.000 rs72936870 chr2:203789679 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs9400271 0.632 rs949881 chr6:109586240 A/G cg01475377 chr6:109611718 NA -0.47 -7.37 -0.41 2.22e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs11203032 0.831 rs11203014 chr10:90940333 C/G cg16672925 chr10:90967113 CH25H 0.75 7.5 0.42 9.62e-13 Heart failure; CESC cis rs151349 0.555 rs151343 chr20:57583298 C/G cg23907860 chr20:57583709 CTSZ 0.53 8.61 0.47 6.51e-16 Platelet distribution width; CESC cis rs7408868 1.000 rs4809030 chr19:15273381 A/G cg14696996 chr19:15285081 NOTCH3 1.11 11.47 0.58 5.57e-25 Pulse pressure; CESC cis rs9487051 0.676 rs2884013 chr6:109599952 C/T cg12927641 chr6:109611667 NA -0.36 -5.43 -0.32 1.28e-7 Reticulocyte fraction of red cells; CESC cis rs34779708 0.931 rs2384275 chr10:35297142 A/G cg03585969 chr10:35415529 CREM 0.75 10.04 0.53 2.57e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs10788264 0.504 rs4751887 chr10:124029758 G/A cg09507567 chr10:124027408 NA 0.4 5.53 0.32 7.61e-8 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16987101 chr1:226297828 NA 0.54 6.29 0.36 1.33e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11618788 chr7:65939595 NA -0.66 -7.76 -0.43 1.89e-13 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27470303 chr10:21823447 MLLT10 0.58 6.06 0.35 4.54e-9 Gut microbiome composition (summer); CESC cis rs3747547 0.642 rs72726054 chr9:38072104 C/G cg13774184 chr9:37916125 SHB -0.68 -5.75 -0.33 2.43e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs9309711 0.736 rs13412581 chr2:3497187 G/A cg10845886 chr2:3471009 TTC15 -0.8 -9.72 -0.51 2.61e-19 Neurofibrillary tangles; CESC cis rs7086627 0.515 rs10887896 chr10:82210144 A/C cg03267442 chr10:82210566 NA -0.33 -5.38 -0.31 1.67e-7 Post bronchodilator FEV1; CESC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg25985355 chr7:65971099 NA 0.32 5.34 0.31 2e-7 Aortic root size; CESC cis rs34779708 0.733 rs7914560 chr10:35548099 G/A cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs7264396 0.635 rs6060656 chr20:34466382 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.47 0.42 1.16e-12 Total cholesterol levels; CESC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg13866156 chr1:1669148 SLC35E2 -0.49 -6.44 -0.37 5.52e-10 Body mass index; CESC cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg14262678 chr6:151773367 RMND1;C6orf211 -0.68 -9.42 -0.5 2.35e-18 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14642636 chr9:71395486 PIP5K1B;FAM122A -0.52 -6.16 -0.35 2.66e-9 Gut microbiome composition (summer); CESC cis rs3096299 0.967 rs7205785 chr16:89458984 A/G cg02187348 chr16:89574699 SPG7 0.56 7.39 0.41 1.96e-12 Multiple myeloma (IgH translocation); CESC cis rs7607369 0.679 rs6751527 chr2:219630965 C/G cg02176678 chr2:219576539 TTLL4 0.47 8.05 0.44 2.74e-14 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs8062405 0.723 rs113208333 chr16:28606160 G/T cg01378222 chr16:28622494 SULT1A1 0.31 5.26 0.31 3.04e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs61931739 0.500 rs34287388 chr12:34444626 C/A cg26384229 chr12:38710491 ALG10B 0.69 10.44 0.54 1.34e-21 Morning vs. evening chronotype; CESC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg26335602 chr6:28129616 ZNF389 0.44 5.61 0.33 5.19e-8 Parkinson's disease; CESC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.31 0.31 2.32e-7 Bipolar disorder; CESC cis rs11785400 1.000 rs4266629 chr8:143736635 A/G cg24634471 chr8:143751801 JRK 0.47 6.25 0.36 1.61e-9 Schizophrenia; CESC cis rs7223966 1.000 rs2013288 chr17:61785904 C/T cg11494091 chr17:61959527 GH2 0.4 5.44 0.32 1.19e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs10740039 0.583 rs1904404 chr10:62502186 A/G cg02922035 chr10:62493342 NA -0.44 -5.15 -0.3 4.98e-7 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs3925075 1.000 rs4411512 chr16:31347445 C/T cg02846316 chr16:31340340 ITGAM 0.41 6.52 0.37 3.54e-10 IgA nephropathy; CESC cis rs2243480 1.000 rs2465120 chr7:65620974 C/G cg18252515 chr7:66147081 NA -1.36 -13.62 -0.64 2.25e-32 Diabetic kidney disease; CESC cis rs10751667 0.621 rs10794348 chr11:939941 G/A cg06064525 chr11:970664 AP2A2 -0.52 -10.43 -0.54 1.43e-21 Alzheimer's disease (late onset); CESC cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg05340658 chr4:99064831 C4orf37 0.69 9.2 0.49 1.08e-17 Colonoscopy-negative controls vs population controls; CESC cis rs4664304 0.742 rs67017730 chr2:160732793 T/G cg03641300 chr2:160917029 PLA2R1 -0.41 -5.46 -0.32 1.07e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs807669 0.903 rs807667 chr22:19161327 A/G cg02655711 chr22:19163373 SLC25A1 -0.94 -14.47 -0.66 2.28e-35 Metabolite levels; CESC cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg11752832 chr7:134001865 SLC35B4 0.51 6.52 0.37 3.61e-10 Mean platelet volume; CESC cis rs9660992 0.710 rs1151787 chr1:205254238 G/A cg21643547 chr1:205240462 TMCC2 -0.45 -6.05 -0.35 4.87e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs892961 0.932 rs8066646 chr17:75414192 C/T cg05865280 chr17:75406074 SEPT9 0.63 12.77 0.62 1.93e-29 Airflow obstruction; CESC trans rs526821 0.595 rs2926309 chr11:55314219 G/A cg15704280 chr7:45808275 SEPT13 -0.52 -6.37 -0.36 8.32e-10 Pediatric bone mineral density (spine); CESC cis rs6430585 0.583 rs7561565 chr2:136640787 A/C cg07169764 chr2:136633963 MCM6 1.24 20.1 0.78 3.22e-55 Corneal structure; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09930017 chr12:125399097 UBC 0.44 6.19 0.36 2.31e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6088590 1.000 rs910870 chr20:33292893 T/C cg08999081 chr20:33150536 PIGU 0.47 6.88 0.39 4.36e-11 Coronary artery disease; CESC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg17376030 chr22:41985996 PMM1 0.71 7.61 0.42 4.72e-13 Vitiligo; CESC cis rs9581857 0.547 rs9319374 chr13:28047587 A/C cg01674679 chr13:27998804 GTF3A -0.63 -5.18 -0.3 4.47e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs6460942 0.597 rs4721106 chr7:12535053 T/C cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs7794273 0.851 rs10251998 chr7:18849259 G/A cg13420273 chr7:18810212 HDAC9 0.35 5.03 0.3 9e-7 Night sleep phenotypes; CESC cis rs9549367 0.789 rs7994324 chr13:113906497 T/C cg18105134 chr13:113819100 PROZ -0.69 -8.35 -0.46 3.87e-15 Platelet distribution width; CESC trans rs7246657 0.943 rs28373708 chr19:37976659 C/T cg24637308 chr11:6592297 DNHD1 0.53 6.13 0.35 3.16e-9 Coronary artery calcification; CESC cis rs1580019 0.921 rs1580023 chr7:32497881 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.13 0.53 1.34e-20 Cognitive ability; CESC cis rs11792861 0.890 rs2900481 chr9:111831825 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 5.26 0.31 3.04e-7 Menarche (age at onset); CESC cis rs546131 0.928 rs552627 chr11:34826680 G/A cg11058730 chr11:34937778 PDHX;APIP 0.5 6.28 0.36 1.39e-9 Lung disease severity in cystic fibrosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16629158 chr2:122042988 TFCP2L1 0.56 6.64 0.38 1.75e-10 Gut microbiome composition (summer); CESC cis rs16917546 0.967 rs10995246 chr10:64391846 C/A cg03961010 chr10:64397487 ZNF365 -0.38 -6.15 -0.35 2.85e-9 Basal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06713521 chr6:7313605 SSR1 0.62 7.45 0.42 1.31e-12 Gut microbiome composition (summer); CESC cis rs8014204 0.762 rs12891131 chr14:75240090 A/G cg08847533 chr14:75593920 NEK9 0.4 5.26 0.31 2.98e-7 Caffeine consumption; CESC cis rs6088580 0.634 rs6058052 chr20:33047084 A/G cg08999081 chr20:33150536 PIGU 0.66 11.67 0.58 1.16e-25 Glomerular filtration rate (creatinine); CESC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs2777491 0.574 rs316616 chr15:41746276 G/A cg18705301 chr15:41695430 NDUFAF1 -1.06 -16.89 -0.72 5.96e-44 Ulcerative colitis; CESC cis rs1215050 0.791 rs260890 chr4:98741698 A/G cg05340658 chr4:99064831 C4orf37 0.49 6.46 0.37 4.89e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9837602 0.529 rs1087198 chr3:99524381 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.62 -9.72 -0.51 2.66e-19 Breast cancer; CESC trans rs2417940 0.799 rs2196028 chr12:21020906 C/T cg19502417 chr1:21930336 RAP1GAP -0.46 -6.03 -0.35 5.49e-9 Bilirubin levels; CESC cis rs820218 0.798 rs9909259 chr17:73648366 G/A cg01592526 chr17:73663357 RECQL5;SAP30BP -0.39 -5.25 -0.31 3.07e-7 Rotator cuff tears; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg07762761 chr8:104033118 ATP6V1C1 -0.52 -7.04 -0.4 1.6e-11 Thyroid stimulating hormone; CESC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg20151795 chr6:28129481 ZNF389 0.46 6.0 0.35 6.52e-9 Depression; CESC cis rs10791097 0.694 rs2155750 chr11:130751261 A/C cg12179176 chr11:130786555 SNX19 0.66 10.37 0.54 2.2e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs12188164 0.582 rs80273890 chr5:483057 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.44 6.18 0.36 2.35e-9 Cystic fibrosis severity; CESC cis rs3749237 0.595 rs11130192 chr3:49467206 C/G cg03060546 chr3:49711283 APEH 0.77 11.69 0.58 9.54e-26 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12876261 chr7:56119223 PSPH;CCT6A 0.61 7.26 0.41 4.39e-12 Gut microbiome composition (summer); CESC cis rs10876993 0.928 rs2640629 chr12:58065448 C/T cg18357645 chr12:58087776 OS9 0.58 9.72 0.51 2.64e-19 Celiac disease or Rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02711724 chr8:130877076 FAM49B -0.7 -7.77 -0.43 1.74e-13 Gut microbiome composition (summer); CESC cis rs35110281 0.744 rs230645 chr21:44918607 A/G cg04455712 chr21:45112962 RRP1B -0.37 -5.65 -0.33 4.03e-8 Mean corpuscular volume; CESC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg05313129 chr8:58192883 C8orf71 -0.56 -6.45 -0.37 5.31e-10 Developmental language disorder (linguistic errors); CESC cis rs10751667 1.000 rs7394449 chr11:962190 T/C cg20946044 chr11:1010712 AP2A2 -0.43 -5.78 -0.33 2.15e-8 Alzheimer's disease (late onset); CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg07424592 chr7:64974309 NA -0.36 -5.26 -0.31 3e-7 Calcium levels; CESC cis rs9467773 1.000 rs9467779 chr6:26536687 A/T cg11502198 chr6:26597334 ABT1 -0.4 -5.67 -0.33 3.71e-8 Intelligence (multi-trait analysis); CESC cis rs10791323 0.519 rs329663 chr11:133754543 A/G cg15485101 chr11:133734466 NA 0.3 5.16 0.3 4.84e-7 Childhood ear infection; CESC cis rs10887741 0.546 rs7078618 chr10:89440911 A/G cg13926569 chr10:89418898 PAPSS2 0.45 7.13 0.4 9.81e-12 Exercise (leisure time); CESC trans rs4756846 1.000 rs17470624 chr11:16445649 C/T cg05579622 chr5:10618622 ANKRD33B 0.76 6.9 0.39 3.87e-11 Obesity and osteoporosis; CESC cis rs11078917 1 rs11078917 chr17:37746359 A/C cg07936489 chr17:37558343 FBXL20 -0.76 -10.13 -0.53 1.39e-20 Mean corpuscular volume; CESC cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 11.99 0.59 9.53e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11122272 0.668 rs1122131 chr1:231476501 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.46 -6.29 -0.36 1.33e-9 Hemoglobin concentration; CESC cis rs2204008 0.837 rs11514225 chr12:38076270 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.76 0.38 8.83e-11 Bladder cancer; CESC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg04944784 chr2:26401820 FAM59B -0.67 -7.75 -0.43 2e-13 Gut microbiome composition (summer); CESC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg25838465 chr1:92012736 NA 0.53 7.21 0.4 5.96e-12 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02102644 chr17:35969361 SYNRG -0.47 -6.12 -0.35 3.27e-9 Ulcerative colitis; CESC cis rs6120849 0.754 rs6120812 chr20:33629427 T/C cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs9457247 0.663 rs2301436 chr6:167437988 C/T cg07741184 chr6:167504864 NA 0.34 5.97 0.34 7.46e-9 Crohn's disease; CESC cis rs73206853 0.563 rs1050587 chr12:111158161 T/C cg12870014 chr12:110450643 ANKRD13A 0.64 5.57 0.32 6.19e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs459571 0.959 rs2520099 chr9:136918139 T/C cg09836344 chr4:1243392 C4orf42;CTBP1 -0.57 -7.56 -0.42 6.72e-13 Platelet distribution width; CESC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.93 14.18 0.66 2.45e-34 Prudent dietary pattern; CESC cis rs854765 0.724 rs62072049 chr17:17906520 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.29 0.36 1.27e-9 Total body bone mineral density; CESC cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg04450456 chr4:17643702 FAM184B 0.42 5.98 0.34 7.07e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6060717 0.610 rs2590965 chr20:34613120 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.59 7.88 0.44 8.32e-14 Hip circumference adjusted for BMI; CESC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg03806693 chr22:41940476 POLR3H 1.18 13.88 0.65 2.76e-33 Vitiligo; CESC trans rs801193 1.000 rs2659915 chr7:66153101 A/G cg26939375 chr7:64535504 NA 0.62 8.39 0.46 3e-15 Aortic root size; CESC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg17376030 chr22:41985996 PMM1 -0.76 -8.28 -0.45 6.12e-15 Vitiligo; CESC cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg22823121 chr1:150693482 HORMAD1 -0.36 -5.39 -0.31 1.54e-7 Tonsillectomy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20554397 chr5:303564 PDCD6;AHRR 0.45 6.17 0.35 2.55e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.1 -12.71 -0.62 3.31e-29 Gut microbiome composition (summer); CESC cis rs1568889 1.000 rs12803716 chr11:28055111 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.85 0.55 6.02e-23 Bipolar disorder; CESC cis rs4566357 0.615 rs4350744 chr2:227918146 A/T cg05526886 chr2:227700861 RHBDD1 -0.52 -6.84 -0.39 5.61e-11 Coronary artery disease; CESC cis rs4481887 0.927 rs10127803 chr1:248476196 A/T cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs938554 0.612 rs28592748 chr4:9998605 T/C cg00071950 chr4:10020882 SLC2A9 0.62 7.37 0.41 2.23e-12 Blood metabolite levels; CESC cis rs708547 0.647 rs1718878 chr4:57876955 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -5.58 -0.32 6.06e-8 Response to bleomycin (chromatid breaks); CESC cis rs6842047 1.000 rs10471184 chr4:187122904 C/T cg09526685 chr4:187126073 CYP4V2 -0.7 -5.67 -0.33 3.66e-8 Blood protein levels; CESC cis rs730775 0.505 rs325004 chr6:44270365 C/G cg21130236 chr6:44246755 TMEM151B -0.27 -5.29 -0.31 2.58e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg26335602 chr6:28129616 ZNF389 -0.56 -7.66 -0.43 3.42e-13 Depression; CESC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg06221963 chr1:154839813 KCNN3 -0.59 -9.36 -0.5 3.66e-18 Prostate cancer; CESC cis rs17376456 0.877 rs12374463 chr5:93483569 C/G cg25358565 chr5:93447407 FAM172A 1.15 10.91 0.56 3.79e-23 Diabetic retinopathy; CESC cis rs7208859 0.623 rs11657662 chr17:29076347 A/G cg14008862 chr17:28927542 LRRC37B2 -0.72 -5.48 -0.32 9.7e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg25072359 chr17:41440525 NA 0.47 6.45 0.37 5.36e-10 Menopause (age at onset); CESC trans rs57221529 0.709 rs111352378 chr5:577079 G/A cg25482853 chr8:67687455 SGK3 1.01 10.17 0.53 9.74e-21 Lung disease severity in cystic fibrosis; CESC cis rs17253792 0.822 rs75399477 chr14:56174413 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.78 5.35 0.31 1.87e-7 Putamen volume; CESC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg07507251 chr3:52567010 NT5DC2 0.32 5.58 0.32 5.82e-8 Bipolar disorder; CESC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg16743903 chr16:89593216 SPG7 -0.49 -6.4 -0.37 7e-10 Multiple myeloma (IgH translocation); CESC cis rs858239 0.614 rs10229956 chr7:23402936 C/G cg23682824 chr7:23144976 KLHL7 -0.42 -5.26 -0.31 2.93e-7 Cerebrospinal fluid biomarker levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25680105 chr8:82434497 NA -0.57 -6.05 -0.35 4.93e-9 Gut microbiome composition (summer); CESC cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg19748678 chr4:122722346 EXOSC9 0.72 9.38 0.5 3.07e-18 Type 2 diabetes; CESC cis rs9443645 0.527 rs10943596 chr6:79575292 C/T cg05283184 chr6:79620031 NA -0.36 -5.1 -0.3 6.62e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg03467027 chr4:99064603 C4orf37 0.45 5.67 0.33 3.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6964587 0.934 rs35968894 chr7:91762145 A/G cg17063962 chr7:91808500 NA 0.52 6.2 0.36 2.15e-9 Breast cancer; CESC cis rs11098499 0.569 rs10023641 chr4:120258410 C/G cg09307838 chr4:120376055 NA 0.76 10.33 0.54 3.02e-21 Corneal astigmatism; CESC cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg00033643 chr7:134001901 SLC35B4 0.4 5.19 0.3 4.14e-7 Mean platelet volume; CESC trans rs61931739 0.500 rs11053208 chr12:34460029 A/G cg26384229 chr12:38710491 ALG10B 0.56 7.72 0.43 2.42e-13 Morning vs. evening chronotype; CESC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09333889 chr11:18211133 NA -0.43 -6.21 -0.36 2.09e-9 Gut microbiota (bacterial taxa); CESC cis rs7551222 0.749 rs6594019 chr1:204568610 T/C cg20240347 chr1:204465584 NA -0.26 -5.26 -0.31 2.99e-7 Schizophrenia; CESC cis rs80282103 0.618 rs11250252 chr10:1124939 G/C cg08668510 chr10:1095578 IDI1 0.72 5.7 0.33 3.12e-8 Glomerular filtration rate (creatinine); CESC cis rs7651736 1.000 rs7651736 chr3:136760598 A/G cg25687071 chr3:136751404 NA 0.34 5.07 0.3 7.4e-7 Neuroticism; CESC cis rs34638657 0.732 rs2967359 chr16:82202968 G/C cg09439754 chr16:82129088 HSD17B2 -0.37 -6.4 -0.37 7.17e-10 Lung adenocarcinoma; CESC cis rs6688613 0.579 rs4657609 chr1:166839174 G/A cg07049167 chr1:166818506 POGK 0.44 5.07 0.3 7.39e-7 Refractive astigmatism; CESC trans rs6693417 0.965 rs6700655 chr1:15759547 A/T cg23732560 chr3:45267976 TMEM158 -0.54 -6.14 -0.35 3.03e-9 Alcoholic chronic pancreatitis; CESC cis rs3008870 0.727 rs11208971 chr1:67383901 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.64 8.41 0.46 2.52e-15 Lymphocyte percentage of white cells; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg04355093 chr4:85887382 WDFY3;C4orf12 -0.43 -6.15 -0.35 2.78e-9 Breast cancer; CESC cis rs870825 0.616 rs4519838 chr4:185628457 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.03 0.4 1.8e-11 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08642743 chr17:74099944 EXOC7 0.58 6.6 0.38 2.29e-10 Gut microbiome composition (summer); CESC cis rs2066819 1.000 rs2643626 chr12:56726518 C/T cg26734620 chr12:56694298 CS -0.91 -9.19 -0.49 1.22e-17 Psoriasis vulgaris; CESC cis rs8016982 0.593 rs7160569 chr14:81713686 C/T cg01989461 chr14:81687754 GTF2A1 0.72 11.27 0.57 2.52e-24 Schizophrenia; CESC cis rs4803468 1.000 rs284663 chr19:41932612 C/T cg09537434 chr19:41945824 ATP5SL -1.13 -21.55 -0.8 3.26e-60 Height; CESC cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg05347473 chr6:146136440 FBXO30 0.59 7.63 0.42 4.24e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7647973 0.710 rs2029591 chr3:49646981 C/T cg06212747 chr3:49208901 KLHDC8B -0.66 -7.54 -0.42 7.41e-13 Menarche (age at onset); CESC cis rs10791097 0.547 rs11222371 chr11:130745719 C/T cg12179176 chr11:130786555 SNX19 0.68 10.02 0.52 3.03e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7843479 1.000 rs11775444 chr8:21813018 A/G cg17168535 chr8:21777572 XPO7 0.5 6.79 0.39 7.23e-11 Mean corpuscular volume; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg18315708 chr14:21673796 NA 0.39 6.05 0.35 4.92e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1163251 0.902 rs639216 chr1:120217414 C/T cg19096424 chr1:120255104 PHGDH 0.43 5.22 0.31 3.62e-7 Blood metabolite levels; CESC cis rs870825 0.549 rs28542773 chr4:185617935 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs854765 0.616 rs8070624 chr17:17843396 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.46 6.02 0.35 5.77e-9 Total body bone mineral density; CESC cis rs7258465 0.965 rs10408290 chr19:18542701 C/T cg25828334 chr19:18545568 ISYNA1 -0.32 -5.21 -0.3 3.84e-7 Breast cancer; CESC trans rs6780666 0.509 rs1461513 chr3:136947731 G/A cg16900796 chr19:10755136 SLC44A2 -0.42 -6.4 -0.37 6.83e-10 Intelligence (multi-trait analysis); CESC cis rs7301826 0.967 rs4759792 chr12:131296631 G/A cg11011512 chr12:131303247 STX2 0.4 5.09 0.3 6.83e-7 Plasma plasminogen activator levels; CESC cis rs7210086 0.730 rs76126194 chr17:70638724 G/A cg04206342 chr17:70636940 NA -0.31 -6.08 -0.35 4.29e-9 Ulcerative colitis; CESC cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg27286337 chr10:134555280 INPP5A 0.63 7.33 0.41 2.71e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6575793 0.532 rs11849489 chr14:101037762 C/G cg18516195 chr14:101012996 BEGAIN 0.46 5.57 0.32 6.26e-8 Menarche (age at onset); CESC cis rs9287719 0.967 rs12464908 chr2:10761496 T/G cg02196655 chr2:10830764 NOL10 -0.37 -5.56 -0.32 6.58e-8 Prostate cancer; CESC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.69 0.33 3.42e-8 Personality dimensions; CESC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg11644478 chr21:40555479 PSMG1 1.01 16.06 0.7 5.44e-41 Cognitive function; CESC cis rs11718455 0.920 rs34909426 chr3:44000472 G/A cg08738300 chr3:44038990 NA 0.46 6.22 0.36 1.96e-9 Coronary artery disease; CESC cis rs4808199 0.947 rs751858 chr19:19602821 G/C cg03709012 chr19:19516395 GATAD2A 1.11 13.29 0.63 3.07e-31 Nonalcoholic fatty liver disease; CESC trans rs35110281 0.622 rs9977258 chr21:44976485 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.61 8.31 0.45 4.9e-15 Mean corpuscular volume; CESC cis rs2066819 1.000 rs2066819 chr12:56750204 C/T cg26734620 chr12:56694298 CS 0.97 5.81 0.34 1.76e-8 Psoriasis vulgaris; CESC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg15664640 chr17:80829946 TBCD -0.68 -10.03 -0.52 2.82e-20 Breast cancer; CESC cis rs7312933 0.703 rs11181380 chr12:42616040 A/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.34 0.36 9.66e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg02951883 chr7:2050386 MAD1L1 -0.46 -5.99 -0.35 6.84e-9 Bipolar disorder and schizophrenia; CESC cis rs34779708 0.966 rs2126984 chr10:35410291 A/G cg03585969 chr10:35415529 CREM 0.77 9.86 0.52 9.37e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg18230493 chr5:56204884 C5orf35 0.61 7.82 0.43 1.27e-13 Initial pursuit acceleration; CESC cis rs763121 0.925 rs5750654 chr22:39051428 T/C cg21395723 chr22:39101663 GTPBP1 0.46 5.98 0.34 7.22e-9 Menopause (age at onset); CESC cis rs13385 0.769 rs13163983 chr5:139622572 A/C cg26211634 chr5:139558579 C5orf32 0.48 5.23 0.31 3.5e-7 Atrial fibrillation; CESC cis rs7267979 0.873 rs6037062 chr20:25202892 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.79 14.91 0.68 6.38e-37 Liver enzyme levels (alkaline phosphatase); CESC cis rs965469 1.000 rs6037551 chr20:3306690 T/C cg25506879 chr20:3388711 C20orf194 -0.58 -6.16 -0.35 2.76e-9 IFN-related cytopenia; CESC cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg25427524 chr10:38739819 LOC399744 -0.67 -9.72 -0.51 2.65e-19 Extrinsic epigenetic age acceleration; CESC cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg03433033 chr1:76189801 ACADM 0.58 5.68 0.33 3.6e-8 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24689585 chr15:22957012 CYFIP1 -0.55 -6.53 -0.37 3.42e-10 Gut microbiome composition (summer); CESC cis rs2742234 0.541 rs1254959 chr10:43700979 C/G cg15436174 chr10:43711423 RASGEF1A 0.5 5.85 0.34 1.45e-8 Hirschsprung disease; CESC cis rs2415984 0.579 rs2255935 chr14:46964271 A/G cg14871534 chr14:47121158 RPL10L 0.35 5.32 0.31 2.24e-7 Number of children ever born; CESC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.63 0.38 1.84e-10 Bipolar disorder; CESC cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg20476274 chr7:133979776 SLC35B4 0.67 9.78 0.52 1.72e-19 Mean platelet volume; CESC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg05332525 chr7:65337924 VKORC1L1 0.47 5.88 0.34 1.2e-8 Calcium levels; CESC cis rs916888 0.773 rs199534 chr17:44824213 T/G cg27589368 chr17:43923255 LOC100128977;IMP5 -0.39 -5.38 -0.31 1.65e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.07 -0.35 4.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2235544 0.565 rs677481 chr1:54468837 A/C cg25741118 chr1:54482237 LDLRAD1 0.24 5.77 0.33 2.2e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg24549020 chr5:56110836 MAP3K1 0.52 5.94 0.34 9.14e-9 Type 2 diabetes; CESC cis rs10504229 0.639 rs112926738 chr8:58054939 A/G cg22535103 chr8:58192502 C8orf71 -0.77 -8.08 -0.44 2.33e-14 Developmental language disorder (linguistic errors); CESC cis rs62344088 0.590 rs61710713 chr5:181499 G/A cg22857025 chr5:266934 NA -1.24 -7.19 -0.4 6.42e-12 Asthma (childhood onset); CESC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg15052019 chr19:19431593 KIAA0892;SF4 0.41 5.1 0.3 6.45e-7 Tonsillectomy; CESC cis rs12325245 0.536 rs34161389 chr16:58622604 G/A cg02549819 chr16:58548995 SETD6 0.95 6.11 0.35 3.54e-9 Schizophrenia; CESC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg17221315 chr6:27791827 HIST1H4J 0.45 5.81 0.34 1.75e-8 Cardiac Troponin-T levels; CESC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg10018233 chr7:150070692 REPIN1 0.42 6.31 0.36 1.19e-9 Blood protein levels;Circulating chemerin levels; CESC trans rs877282 0.898 rs11253353 chr10:766862 C/A cg22713356 chr15:30763199 NA 1.18 11.28 0.57 2.33e-24 Uric acid levels; CESC cis rs11792861 0.926 rs7470160 chr9:111844246 C/A cg13535736 chr9:111863775 C9orf5 -0.51 -6.76 -0.38 8.77e-11 Menarche (age at onset); CESC cis rs12477438 0.798 rs6761570 chr2:99577276 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.22 -0.53 6.79e-21 Chronic sinus infection; CESC cis rs116095464 0.558 rs112343653 chr5:257174 G/A cg22496380 chr5:211416 CCDC127 -0.73 -8.39 -0.46 2.99e-15 Breast cancer; CESC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg13628971 chr7:2884303 GNA12 0.63 8.23 0.45 8.48e-15 Height; CESC cis rs4900538 0.855 rs72698597 chr14:102868633 C/T cg18135206 chr14:102964638 TECPR2 -0.73 -9.33 -0.5 4.35e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs10751667 0.961 rs7482484 chr11:927020 C/T cg00159523 chr10:114713187 TCF7L2 -0.41 -6.13 -0.35 3.1e-9 Alzheimer's disease (late onset); CESC cis rs6088580 0.524 rs6142210 chr20:33223012 C/T cg08999081 chr20:33150536 PIGU -0.47 -6.78 -0.38 7.73e-11 Glomerular filtration rate (creatinine); CESC cis rs2290720 0.896 rs1350351 chr12:101713590 G/A cg22051763 chr12:101673672 UTP20 -0.49 -6.02 -0.35 5.86e-9 Brain structure (hippocampal volume); CESC cis rs1048238 0.506 rs7552077 chr1:16196759 A/G cg21385522 chr1:16154831 NA 0.45 5.85 0.34 1.45e-8 Systolic blood pressure; CESC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg02951883 chr7:2050386 MAD1L1 -0.44 -5.72 -0.33 2.93e-8 Bipolar disorder and schizophrenia; CESC cis rs7520050 0.966 rs785464 chr1:46523089 T/C cg03146154 chr1:46216737 IPP -0.44 -5.73 -0.33 2.68e-8 Red blood cell count;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23366119 chr18:72162949 CNDP2 -0.55 -6.24 -0.36 1.72e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09720205 chr16:57508738 DOK4 -0.57 -6.34 -0.36 9.79e-10 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.21 -0.3 3.8e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7296418 0.699 rs1109559 chr12:123757861 C/T cg00376283 chr12:123451042 ABCB9 0.61 8.6 0.47 6.93e-16 Platelet count; CESC cis rs911555 0.546 rs28798508 chr14:104068970 T/C cg12935359 chr14:103987150 CKB -0.52 -7.65 -0.43 3.64e-13 Intelligence (multi-trait analysis); CESC cis rs7143963 0.636 rs11160706 chr14:103361736 A/G cg24154132 chr14:103367632 TRAF3 -0.35 -6.57 -0.37 2.6200000000000003e-10 Body mass index; CESC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.49 0.32 9.42e-8 Major depressive disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01062786 chr14:20929651 TMEM55B -0.4 -6.32 -0.36 1.09e-9 Gambling; CESC cis rs67311347 1.000 rs1454497 chr3:40496326 C/T cg09455208 chr3:40491958 NA -0.48 -8.25 -0.45 7.35e-15 Renal cell carcinoma; CESC cis rs113835537 0.529 rs11227510 chr11:66281220 T/C cg22134325 chr11:66188745 NPAS4 0.37 5.81 0.34 1.77e-8 Airway imaging phenotypes; CESC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg21770322 chr7:97807741 LMTK2 0.54 8.12 0.45 1.83e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.46 0.37 4.96e-10 Prudent dietary pattern; CESC cis rs55788414 0.860 rs9929059 chr16:81182117 G/C cg06400318 chr16:81190750 PKD1L2 -0.6 -7.09 -0.4 1.24e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs9443189 0.526 rs9359132 chr6:76289553 G/A cg01950844 chr6:76311363 SENP6 0.87 9.54 0.51 9.61e-19 Prostate cancer; CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg08968635 chr6:28129556 ZNF389 0.4 5.44 0.32 1.21e-7 Depression; CESC cis rs9788682 0.947 rs12439240 chr15:78829091 T/C cg24631222 chr15:78858424 CHRNA5 0.76 9.79 0.52 1.67e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs12142240 0.698 rs7548675 chr1:46809321 C/G cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs16854884 0.545 rs7650459 chr3:143658934 C/G cg06585982 chr3:143692056 C3orf58 0.56 7.62 0.42 4.47e-13 Economic and political preferences (feminism/equality); CESC cis rs4906332 0.811 rs2756138 chr14:103996733 C/G cg04998671 chr14:104000505 TRMT61A 0.42 5.17 0.3 4.71e-7 Coronary artery disease; CESC cis rs4654899 0.931 rs7520481 chr1:21140385 T/G cg05370193 chr1:21551575 ECE1 -0.37 -5.38 -0.31 1.66e-7 Superior frontal gyrus grey matter volume; CESC cis rs27434 0.583 rs468130 chr5:96156029 A/G cg16492584 chr5:96139282 ERAP1 -0.36 -5.09 -0.3 6.81e-7 Ankylosing spondylitis; CESC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg14393609 chr7:65229607 NA -0.47 -6.31 -0.36 1.16e-9 Aortic root size; CESC cis rs7520050 0.966 rs1768803 chr1:46546208 T/C cg03146154 chr1:46216737 IPP -0.44 -5.69 -0.33 3.34e-8 Red blood cell count;Reticulocyte count; CESC cis rs672059 0.513 rs627064 chr1:183165716 C/T ch.1.3577855R chr1:183094577 LAMC1 0.51 6.42 0.37 6.1e-10 Hypertriglyceridemia; CESC cis rs2806561 0.765 rs9426692 chr1:23508426 C/T cg12483005 chr1:23474871 LUZP1 0.39 6.06 0.35 4.58e-9 Height; CESC cis rs959260 1.000 rs4788891 chr17:73391145 A/G cg20590849 chr17:73267439 MIF4GD -0.55 -6.35 -0.36 9.37e-10 Systemic lupus erythematosus; CESC trans rs1973993 0.691 rs2985636 chr1:96889884 T/A cg10631902 chr5:14652156 NA 0.61 9.46 0.5 1.8e-18 Weight; CESC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg09491104 chr22:46646882 C22orf40 -0.52 -6.43 -0.37 5.82e-10 LDL cholesterol;Cholesterol, total; CESC cis rs6032067 1.000 rs6032060 chr20:43852454 A/T cg10761708 chr20:43804764 PI3 0.52 6.26 0.36 1.57e-9 Blood protein levels; CESC cis rs1865721 0.761 rs36002108 chr18:73220472 C/T cg26385618 chr18:73139727 C18orf62 -0.53 -7.75 -0.43 2.02e-13 Intelligence; CESC cis rs8051149 0.688 rs55776570 chr16:87869516 C/G cg03408354 chr16:87871219 SLC7A5 -0.46 -5.7 -0.33 3.27e-8 Blood metabolite levels; CESC cis rs35110281 0.837 rs7279968 chr21:45077398 C/G cg21573476 chr21:45109991 RRP1B -0.48 -6.85 -0.39 5.03e-11 Mean corpuscular volume; CESC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.55 0.46 1.01e-15 Electroencephalogram traits; CESC cis rs12477438 0.520 rs11692699 chr2:99730657 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.87 0.7 2.48e-40 Chronic sinus infection; CESC cis rs10129255 0.556 rs6576222 chr14:107184681 G/A cg07958169 chr14:107095056 NA -0.54 -8.61 -0.47 6.64e-16 Kawasaki disease; CESC cis rs1062177 1.000 rs2915880 chr5:151147334 G/A cg00977110 chr5:151150581 G3BP1 0.67 7.27 0.41 3.98e-12 Preschool internalizing problems; CESC cis rs11155671 0.530 rs9968871 chr6:150209196 G/A cg09699651 chr6:150184138 LRP11 0.55 7.44 0.42 1.41e-12 Testicular germ cell tumor; CESC cis rs11997175 0.583 rs7829680 chr8:33794207 C/T ch.8.33884649F chr8:33765107 NA -0.5 -6.42 -0.37 6.32e-10 Body mass index; CESC cis rs6963495 0.818 rs73190200 chr7:105165856 T/C cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg05863683 chr7:1912471 MAD1L1 0.44 6.45 0.37 5.32e-10 Bipolar disorder and schizophrenia; CESC cis rs4450798 0.649 rs9861903 chr3:13786821 G/T cg05589046 chr3:13742034 LOC285375 0.34 5.21 0.3 3.86e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4148883 0.545 rs17595102 chr4:99986316 C/G cg13256891 chr4:100009986 ADH5 0.52 6.35 0.36 9.15e-10 Alcohol dependence; CESC cis rs6570726 0.875 rs373313 chr6:145857791 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.44 0.37 5.7e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs3768617 0.528 rs10737241 chr1:183098208 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 14.0 0.65 1.04e-33 Fuchs's corneal dystrophy; CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg18110333 chr6:292329 DUSP22 -0.73 -9.53 -0.51 1.06e-18 Menopause (age at onset); CESC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.61 -0.33 5.09e-8 Total body bone mineral density; CESC cis rs3741151 0.773 rs73548693 chr11:73286637 G/A cg17517138 chr11:73019481 ARHGEF17 1.02 7.43 0.42 1.51e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg17724175 chr1:150552817 MCL1 -0.33 -5.36 -0.31 1.83e-7 Tonsillectomy; CESC cis rs7267979 1.000 rs2258201 chr20:25272490 G/C cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs7246760 1.000 rs67509260 chr19:9864321 C/T cg02900749 chr2:68251473 NA -0.79 -6.66 -0.38 1.57e-10 Pursuit maintenance gain; CESC cis rs10838687 0.736 rs7118396 chr11:47269936 C/T cg25783544 chr11:47291846 MADD 0.58 6.61 0.38 2.06e-10 Proinsulin levels; CESC cis rs4332037 0.901 rs7791299 chr7:1935598 T/C cg23422044 chr7:1970798 MAD1L1 -0.58 -7.08 -0.4 1.33e-11 Bipolar disorder; CESC cis rs2115630 0.691 rs8040066 chr15:85176465 G/C cg11189052 chr15:85197271 WDR73 -0.47 -6.39 -0.37 7.23e-10 P wave terminal force; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19635158 chr1:27561056 WDTC1 -0.51 -6.22 -0.36 1.9e-9 Ulcerative colitis; CESC cis rs17666538 0.585 rs1037393 chr8:622634 G/C cg07234876 chr8:600039 NA 0.85 6.02 0.35 5.83e-9 IgG glycosylation; CESC trans rs61931739 0.500 rs9705909 chr12:34576419 G/C cg13010199 chr12:38710504 ALG10B 0.52 6.63 0.38 1.86e-10 Morning vs. evening chronotype; CESC cis rs2710642 0.927 rs2539980 chr2:63208460 T/C cg17519650 chr2:63277830 OTX1 0.62 8.31 0.45 4.87e-15 LDL cholesterol levels;LDL cholesterol; CESC cis rs8099014 0.725 rs4245267 chr18:56096214 C/A cg12827950 chr18:55968429 NEDD4L -0.48 -5.34 -0.31 1.96e-7 Platelet count; CESC cis rs7264396 0.563 rs6058312 chr20:34324484 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.88e-22 Total cholesterol levels; CESC cis rs826838 0.935 rs980571 chr12:39127532 C/G cg26384229 chr12:38710491 ALG10B -0.66 -10.65 -0.55 2.77e-22 Heart rate; CESC cis rs1059312 1.000 rs12814773 chr12:129280786 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.73 -10.15 -0.53 1.14e-20 Systemic lupus erythematosus; CESC cis rs8112211 0.681 rs59898212 chr19:38826656 G/C cg14299480 chr19:38876666 GGN -0.44 -6.0 -0.35 6.45e-9 Blood protein levels; CESC cis rs916888 0.773 rs199457 chr17:44795469 C/T cg01570182 chr17:44337453 NA 0.94 10.66 0.55 2.65e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg03060546 chr3:49711283 APEH 0.51 6.18 0.35 2.43e-9 Parkinson's disease; CESC cis rs763121 0.813 rs2179143 chr22:39037984 A/G cg14440974 chr22:39074834 NA -0.36 -5.18 -0.3 4.33e-7 Menopause (age at onset); CESC cis rs6445797 0.632 rs13097030 chr3:56603675 G/A cg13792233 chr3:56591045 CCDC66 0.39 5.08 0.3 7.25e-7 Gastritis; CESC cis rs2880765 0.835 rs4842886 chr15:86035773 G/A cg10818794 chr15:86012489 AKAP13 -0.34 -5.28 -0.31 2.64e-7 Coronary artery disease; CESC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.15e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6570726 0.875 rs416243 chr6:145868081 A/T cg05347473 chr6:146136440 FBXO30 0.48 6.45 0.37 5.27e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2273669 0.667 rs4509156 chr6:109308952 A/C cg05315195 chr6:109294784 ARMC2 0.64 6.36 0.36 8.8e-10 Prostate cancer; CESC cis rs9486715 0.838 rs4839840 chr6:96941149 T/C cg06623918 chr6:96969491 KIAA0776 0.92 14.25 0.66 1.37e-34 Headache; CESC cis rs763121 0.853 rs6001188 chr22:39062194 T/C cg14440974 chr22:39074834 NA -0.4 -5.43 -0.32 1.3e-7 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10251368 chr16:30662726 PRR14 -0.54 -6.75 -0.38 9.28e-11 Ulcerative colitis; CESC cis rs4148883 0.545 rs17595102 chr4:99986316 C/G cg12011299 chr4:100065546 ADH4 0.67 9.19 0.49 1.16e-17 Alcohol dependence; CESC cis rs9487051 0.676 rs4406271 chr6:109598213 G/A cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC cis rs7772486 0.686 rs1292336 chr6:145967818 T/C cg05347473 chr6:146136440 FBXO30 -0.52 -6.89 -0.39 4.01e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9527 0.590 rs7087459 chr10:104790999 T/C cg04362960 chr10:104952993 NT5C2 0.42 5.42 0.32 1.33e-7 Arsenic metabolism; CESC cis rs11229555 0.645 rs61905183 chr11:58228463 T/A cg15696309 chr11:58395628 NA -0.45 -5.22 -0.31 3.63e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg26069066 chr20:44044698 PIGT 0.46 6.29 0.36 1.29e-9 Bronchopulmonary dysplasia; CESC cis rs826838 0.935 rs10875816 chr12:38955014 C/A cg13010199 chr12:38710504 ALG10B 0.59 8.35 0.46 3.8e-15 Heart rate; CESC cis rs12822507 0.684 rs6488533 chr12:12752586 A/G cg11838227 chr12:12764436 CREBL2 0.42 5.58 0.32 5.87e-8 Systemic lupus erythematosus; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg15941057 chr17:27169869 C17orf63 -0.48 -6.36 -0.36 8.93e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs8103278 0.507 rs10401971 chr19:46261982 C/T cg06577658 chr19:46296270 DMWD 0.43 5.27 0.31 2.76e-7 Coronary artery disease; CESC cis rs1401999 1.000 rs6443924 chr3:183679532 A/G cg01324343 chr3:183735012 ABCC5 0.63 13.41 0.64 1.17e-31 Anterior chamber depth; CESC cis rs7809950 0.906 rs62483723 chr7:107186358 A/C cg23024343 chr7:107201750 COG5 -0.41 -5.65 -0.33 4.03e-8 Coronary artery disease; CESC cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg10523679 chr1:76189770 ACADM 0.71 8.42 0.46 2.39e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.46 7.65 0.43 3.71e-13 Monocyte percentage of white cells; CESC cis rs17376456 0.825 rs13182631 chr5:93115701 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.26 0.31 3.01e-7 Diabetic retinopathy; CESC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.49 -5.2 -0.3 4.06e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs2018683 0.600 rs6948880 chr7:29003478 C/T cg19402173 chr7:128379420 CALU -0.54 -6.71 -0.38 1.15e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs8141529 0.702 rs8137262 chr22:29292135 C/T cg15103426 chr22:29168792 CCDC117 0.6 7.75 0.43 1.97e-13 Lymphocyte counts; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14513222 chr9:140079404 ANAPC2 0.5 6.37 0.36 8.23e-10 Ulcerative colitis; CESC cis rs4604732 0.578 rs12036417 chr1:247624805 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4654899 0.931 rs2275468 chr1:21220375 T/G cg05370193 chr1:21551575 ECE1 -0.35 -5.11 -0.3 6.09e-7 Superior frontal gyrus grey matter volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16457027 chr3:9834426 ARPC4;TADA3 0.63 6.74 0.38 9.85e-11 Gut microbiome composition (summer); CESC cis rs9359856 0.564 rs17584108 chr6:90458209 T/C cg13799429 chr6:90582589 CASP8AP2 -0.6 -5.62 -0.33 4.75e-8 Bipolar disorder; CESC cis rs7474896 0.583 rs11011341 chr10:37998500 G/A cg25427524 chr10:38739819 LOC399744 -0.44 -5.15 -0.3 5.03e-7 Obesity (extreme); CESC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -7.97 -0.44 4.6e-14 Developmental language disorder (linguistic errors); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04579211 chr15:41221939 DLL4 -0.43 -6.46 -0.37 5e-10 Gambling; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09246754 chr10:74855561 P4HA1 0.48 6.55 0.37 2.95e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg08289140 chr1:1535155 NA 0.51 6.0 0.35 6.36e-9 Psoriatic arthritis; CESC cis rs6728642 0.519 rs62152906 chr2:97572270 T/C cg26665480 chr2:98280029 ACTR1B -0.58 -5.28 -0.31 2.75e-7 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg22875332 chr1:76189707 ACADM 0.69 9.3 0.5 5.49e-18 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00974835 chr14:74960278 NPC2;ISCA2 0.68 7.7 0.43 2.67e-13 Gut microbiome composition (summer); CESC cis rs2404602 0.692 rs8043474 chr15:76974723 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.15 -0.3 5.13e-7 Blood metabolite levels; CESC cis rs7772486 0.727 rs10223508 chr6:146285205 C/T cg05347473 chr6:146136440 FBXO30 -0.51 -6.52 -0.37 3.48e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs17209837 1.000 rs45502492 chr7:87089898 C/T cg00919237 chr7:87102261 ABCB4 -0.53 -6.03 -0.35 5.36e-9 Gallbladder cancer; CESC cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg22834771 chr12:69754056 YEATS4 -0.55 -7.29 -0.41 3.61e-12 Cerebrospinal fluid biomarker levels; CESC cis rs9457247 0.967 rs1590257 chr6:167377782 G/T cg23791538 chr6:167370224 RNASET2 0.6 8.57 0.47 8.75e-16 Crohn's disease; CESC trans rs3087243 0.755 rs231789 chr2:204699952 C/T cg01841312 chr10:38069945 NA 0.38 6.43 0.37 5.77e-10 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs672059 1.000 rs659307 chr1:183163078 G/A ch.1.3577855R chr1:183094577 LAMC1 0.56 7.19 0.4 6.53e-12 Hypertriglyceridemia; CESC cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg22875332 chr1:76189707 ACADM -0.64 -6.77 -0.38 8.23e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9291683 0.526 rs12506122 chr4:10033538 C/A cg00071950 chr4:10020882 SLC2A9 0.82 13.85 0.65 3.37e-33 Bone mineral density; CESC cis rs7264396 0.676 rs6060730 chr20:34558503 G/A cg17201900 chr20:34330562 RBM39 0.51 5.31 0.31 2.37e-7 Total cholesterol levels; CESC cis rs4764487 0.735 rs3181291 chr12:6341499 C/T cg08284733 chr12:6341482 CD9 0.36 5.39 0.31 1.56e-7 Mean platelet volume; CESC cis rs6088590 1.000 rs28542147 chr20:33376323 G/A cg24642439 chr20:33292090 TP53INP2 0.84 11.76 0.59 5.5e-26 Coronary artery disease; CESC cis rs7833986 0.501 rs17812659 chr8:56889862 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.57 6.86 0.39 4.81e-11 Height; CESC cis rs634534 0.622 rs624273 chr11:65712413 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.46 6.66 0.38 1.62e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs4974559 0.594 rs59544360 chr4:1313575 G/T cg02980000 chr4:1222292 CTBP1 0.66 7.16 0.4 7.91e-12 Systolic blood pressure; CESC cis rs7560272 0.538 rs13014700 chr2:73920121 C/G cg20560298 chr2:73613845 ALMS1 0.45 6.16 0.35 2.73e-9 Schizophrenia; CESC cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg00409905 chr10:38381863 ZNF37A -0.46 -6.18 -0.35 2.39e-9 Extrinsic epigenetic age acceleration; CESC cis rs1355223 0.902 rs10501134 chr11:34749137 T/C cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.13 -0.35 3.23e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs9486715 0.830 rs2255552 chr6:96999643 A/G cg16678718 chr17:76497959 DNAH17 -0.44 -6.03 -0.35 5.47e-9 Headache; CESC trans rs3808502 0.516 rs6983727 chr8:11415812 A/G cg15556689 chr8:8085844 FLJ10661 0.6 7.08 0.4 1.27e-11 Neuroticism; CESC cis rs62408225 0.888 rs58453446 chr6:90948093 G/C cg06866423 chr6:90926672 BACH2 0.49 5.93 0.34 9.32e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg04315214 chr1:2043799 PRKCZ 0.61 10.75 0.55 1.34e-22 Height; CESC cis rs78456975 1.000 rs10177095 chr2:1570976 C/A cg26248373 chr2:1572462 NA -0.56 -5.28 -0.31 2.66e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs1568889 1.000 rs7102106 chr11:28343953 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 9.64 0.51 4.7e-19 Bipolar disorder; CESC cis rs11931598 0.702 rs10937780 chr4:7048842 A/G cg26116260 chr4:7069785 GRPEL1 -0.39 -5.29 -0.31 2.6e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg18876405 chr7:65276391 NA -0.68 -9.52 -0.5 1.1e-18 Aortic root size; CESC cis rs7762018 0.769 rs74838157 chr6:170077323 G/A cg05834625 chr6:170176447 C6orf70 0.7 6.82 0.39 6.26e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2652834 1.000 rs2652832 chr15:63396928 T/C cg05507819 chr15:63340323 TPM1 0.55 5.13 0.3 5.53e-7 HDL cholesterol; CESC cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg21881798 chr11:8931708 C11orf17;ST5 -0.46 -7.75 -0.43 1.95e-13 Hemoglobin concentration; CESC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg18876405 chr7:65276391 NA -0.53 -7.25 -0.41 4.64e-12 Aortic root size; CESC cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.22e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3733585 0.673 rs4467564 chr4:9953472 G/T cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7116495 0.609 rs2276384 chr11:71701523 A/G cg26138937 chr11:71823887 C11orf51 1.14 7.69 0.43 2.82e-13 Severe influenza A (H1N1) infection; CESC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.93 9.65 0.51 4.31e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs12229918 0.540 rs10784460 chr12:65863584 C/T cg09253914 chr2:37311580 HEATR5B;CCDC75 -0.5 -6.13 -0.35 3.23e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CESC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg11764359 chr7:65958608 NA -0.78 -11.32 -0.57 1.76e-24 Aortic root size; CESC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg03388025 chr16:89894329 SPIRE2 -0.39 -7.48 -0.42 1.1e-12 Vitiligo; CESC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg05863683 chr7:1912471 MAD1L1 0.47 7.07 0.4 1.37e-11 Bipolar disorder and schizophrenia; CESC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg01416388 chr22:39784598 NA -0.63 -7.93 -0.44 6.22e-14 Intelligence (multi-trait analysis); CESC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg07395648 chr5:131743802 NA 0.41 5.33 0.31 2.09e-7 Breast cancer; CESC cis rs7914558 0.933 rs12763665 chr10:104653717 G/A cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.45e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs9586179 1.000 rs10220061 chr13:104047061 A/G cg13539803 chr13:110424782 IRS2 0.88 6.18 0.35 2.41e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid); CESC cis rs524023 0.957 rs12365089 chr11:64364735 A/T cg07220939 chr11:64358617 SLC22A12 -0.36 -5.55 -0.32 6.77e-8 Urate levels in obese individuals; CESC cis rs6942756 1.000 rs2718084 chr7:128897342 T/C cg02491457 chr7:128862824 NA 0.69 10.33 0.54 3.15e-21 White matter hyperintensity burden; CESC cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg00475322 chr7:917719 C7orf20 0.47 6.97 0.39 2.5e-11 Perceived unattractiveness to mosquitoes; CESC cis rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22212156 chr20:32031449 SNTA1 -0.48 -5.94 -0.34 8.98e-9 Ulcerative colitis; CESC cis rs2120019 0.938 rs8028632 chr15:75321262 T/C cg17294928 chr15:75287854 SCAMP5 -0.76 -8.79 -0.48 1.96e-16 Blood trace element (Zn levels); CESC cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg23711669 chr6:146136114 FBXO30 -0.96 -14.87 -0.67 8.61e-37 Lobe attachment (rater-scored or self-reported); CESC trans rs1814175 0.645 rs4625470 chr11:49983769 T/C cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs7647973 1.000 rs9860055 chr3:49506900 C/T cg06212747 chr3:49208901 KLHDC8B -0.59 -7.8 -0.43 1.43e-13 Menarche (age at onset); CESC cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg19748678 chr4:122722346 EXOSC9 0.79 10.06 0.53 2.23e-20 Type 2 diabetes; CESC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg09365446 chr1:150670422 GOLPH3L 0.39 5.11 0.3 6.21e-7 Melanoma; CESC cis rs10883723 0.738 rs715438 chr10:104258303 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.25 0.41 4.46e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs7520050 0.778 rs12404197 chr1:46232420 G/A cg24296786 chr1:45957014 TESK2 0.46 5.99 0.35 6.97e-9 Red blood cell count;Reticulocyte count; CESC cis rs617219 0.889 rs4466139 chr5:78430058 T/C cg22188827 chr5:78429774 NA -0.41 -5.03 -0.3 9.19e-7 Betaine levels in individuals undergoing cardiac evaluation; CESC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg22800045 chr5:56110881 MAP3K1 0.44 5.36 0.31 1.8e-7 Coronary artery disease; CESC cis rs9341835 0.518 rs2758237 chr6:64218297 G/A cg03326410 chr6:64151739 NA 0.32 5.15 0.3 5.1e-7 Schizophrenia; CESC trans rs10791097 0.694 rs3190331 chr11:130748131 C/T cg10101470 chr1:90286633 LRRC8D -0.44 -6.02 -0.35 5.75e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs875971 0.619 rs2302918 chr7:66000932 A/G cg26939375 chr7:64535504 NA 0.64 8.52 0.46 1.2e-15 Aortic root size; CESC cis rs9611565 0.546 rs5758431 chr22:42109917 A/G cg03806693 chr22:41940476 POLR3H 1.05 11.94 0.59 1.39e-26 Vitiligo; CESC cis rs7264396 0.561 rs66483315 chr20:34573575 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.52 5.93 0.34 9.55e-9 Total cholesterol levels; CESC cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg12365402 chr11:9010492 NRIP3 -0.49 -8.39 -0.46 2.89e-15 Hemoglobin concentration; CESC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg02463440 chr8:22132932 PIWIL2 0.38 5.83 0.34 1.64e-8 Hypertriglyceridemia; CESC cis rs73411413 0.661 rs11599981 chr11:1520063 C/T cg20027784 chr11:1520631 HCCA2 -0.44 -5.18 -0.3 4.3e-7 Myringotomy; CESC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg08470875 chr2:26401718 FAM59B -0.63 -7.29 -0.41 3.6e-12 Gut microbiome composition (summer); CESC cis rs2439831 0.850 rs28513374 chr15:44125495 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.6 0.33 5.26e-8 Lung cancer in ever smokers; CESC cis rs11098499 0.954 rs17046116 chr4:120387259 G/A cg24375607 chr4:120327624 NA 0.44 5.48 0.32 9.91e-8 Corneal astigmatism; CESC cis rs56235845 0.694 rs12055081 chr5:176757191 C/T cg16006841 chr5:176797999 RGS14 0.47 5.86 0.34 1.4e-8 Hemoglobin concentration;Hematocrit; CESC cis rs7520050 0.933 rs11211203 chr1:46315592 A/G cg03146154 chr1:46216737 IPP -0.47 -6.15 -0.35 2.87e-9 Red blood cell count;Reticulocyte count; CESC cis rs116095464 0.850 rs10055295 chr5:243749 G/A cg20965017 chr5:231967 SDHA -0.47 -5.38 -0.31 1.65e-7 Breast cancer; CESC cis rs10089 1.000 rs7703634 chr5:127509223 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 9.32 0.5 4.86e-18 Ileal carcinoids; CESC cis rs67460515 0.563 rs9876142 chr3:160780968 A/G cg03342759 chr3:160939853 NMD3 0.49 6.0 0.35 6.59e-9 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03940137 chr1:200708937 CAMSAP1L1 0.67 7.45 0.42 1.36e-12 Gut microbiome composition (summer); CESC cis rs6977955 1.000 rs4722760 chr7:28172183 C/T cg23620719 chr7:28220237 JAZF1 -0.58 -6.56 -0.37 2.77e-10 Allergic disease (asthma, hay fever or eczema); CESC cis rs8092503 1.000 rs12456067 chr18:52499448 C/T cg12377874 chr18:52495404 RAB27B 0.37 6.11 0.35 3.62e-9 Childhood body mass index; CESC cis rs35146811 0.807 rs6465761 chr7:99620277 G/C cg22906224 chr7:99728672 NA 0.48 5.73 0.33 2.73e-8 Coronary artery disease; CESC trans rs61931739 0.500 rs34997501 chr12:34549828 C/G cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC cis rs897984 0.511 rs7196726 chr16:31092075 G/A cg02466173 chr16:30829666 NA -0.4 -6.89 -0.39 3.99e-11 Dementia with Lewy bodies; CESC trans rs3741489 1.000 rs10781661 chr12:133431979 G/A cg24132527 chr5:140019269 TMCO6 1.17 8.58 0.47 8.06e-16 Cognitive function; CESC cis rs3768617 0.706 rs9943067 chr1:182975102 C/T ch.1.3577855R chr1:183094577 LAMC1 0.7 10.06 0.53 2.21e-20 Fuchs's corneal dystrophy; CESC cis rs4910157 1 rs4910157 chr11:8941215 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.46 7.29 0.41 3.49e-12 Tonsillectomy; CESC cis rs62229266 0.804 rs880221 chr21:37420785 C/T cg08632701 chr21:37451849 NA -0.37 -5.2 -0.3 3.98e-7 Mitral valve prolapse; CESC cis rs7208859 0.573 rs73267829 chr17:29003939 G/A cg14008862 chr17:28927542 LRRC37B2 0.73 5.8 0.34 1.85e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg05368731 chr17:41323189 NBR1 0.56 7.56 0.42 6.43e-13 Menopause (age at onset); CESC cis rs2710642 0.962 rs6545972 chr2:63084682 G/A cg17519650 chr2:63277830 OTX1 0.53 6.77 0.38 8.11e-11 LDL cholesterol levels;LDL cholesterol; CESC cis rs8023845 1.000 rs3759843 chr15:40453075 A/G cg20259534 chr15:40453036 BUB1B -0.69 -7.02 -0.4 1.87e-11 Chronic lymphocytic leukemia; CESC cis rs3820068 0.603 rs1122387 chr1:15947282 T/C cg13390004 chr1:15929781 NA 0.37 5.95 0.34 8.6e-9 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02040921 chr17:61554411 ACE 0.55 6.25 0.36 1.62e-9 Gut microbiome composition (summer); CESC cis rs7116495 0.609 rs7126394 chr11:71685429 A/G cg26138937 chr11:71823887 C11orf51 -1.26 -8.05 -0.44 2.83e-14 Severe influenza A (H1N1) infection; CESC cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg24296786 chr1:45957014 TESK2 0.66 8.96 0.48 6.06e-17 High light scatter reticulocyte count; CESC cis rs9359856 0.510 rs2768940 chr6:90436319 A/G cg13799429 chr6:90582589 CASP8AP2 -0.73 -8.34 -0.46 4.01e-15 Bipolar disorder; CESC cis rs4561483 0.603 rs62038777 chr16:11934176 A/C cg08843971 chr16:11963173 GSPT1 0.5 6.86 0.39 4.99e-11 Testicular germ cell tumor; CESC cis rs9583531 0.600 rs754599 chr13:111354788 C/A cg15841412 chr13:111365552 ING1 0.49 6.31 0.36 1.19e-9 Coronary artery disease; CESC cis rs2290159 0.800 rs5746193 chr3:12658601 C/T cg23032965 chr3:12705835 RAF1 0.53 5.68 0.33 3.58e-8 Cholesterol, total; CESC cis rs1018836 0.786 rs7016220 chr8:91606848 A/G cg16814680 chr8:91681699 NA -0.71 -10.58 -0.54 4.89e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs897984 0.762 rs2054213 chr16:30971810 A/G cg02466173 chr16:30829666 NA 0.49 8.16 0.45 1.35e-14 Dementia with Lewy bodies; CESC cis rs11247915 0.561 rs11583258 chr1:26624270 C/T cg00852783 chr1:26633632 UBXN11 0.42 5.16 0.3 4.82e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21000493 chr7:39772967 LOC349114 0.58 6.48 0.37 4.45e-10 Gut microbiome composition (summer); CESC cis rs3015497 0.603 rs3015462 chr14:51034617 C/A cg26011998 chr14:51135199 SAV1 0.49 5.45 0.32 1.16e-7 Mean platelet volume; CESC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg26441486 chr22:50317300 CRELD2 0.41 5.22 0.31 3.7e-7 Schizophrenia; CESC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg25985355 chr7:65971099 NA 0.33 5.39 0.31 1.53e-7 Aortic root size; CESC cis rs2075371 0.579 rs11766422 chr7:134018160 T/C cg11752832 chr7:134001865 SLC35B4 0.43 5.11 0.3 6.32e-7 Mean platelet volume; CESC cis rs4242434 0.927 rs11136093 chr8:22479988 C/G cg03733263 chr8:22462867 KIAA1967 0.94 12.76 0.62 2.16e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs1499614 1.000 rs1267817 chr7:66110040 G/T cg18252515 chr7:66147081 NA -1.4 -14.2 -0.66 2.03e-34 Gout; CESC cis rs2204008 0.837 rs7308714 chr12:38274307 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.7 0.51 3.2e-19 Bladder cancer; CESC cis rs854765 0.647 rs4365346 chr17:17989373 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.56 0.47 9.59e-16 Total body bone mineral density; CESC cis rs2797160 0.935 rs1739372 chr6:126011325 G/A cg05901451 chr6:126070800 HEY2 0.46 6.67 0.38 1.45e-10 Endometrial cancer; CESC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 10.66 0.55 2.67e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg11952622 chr19:58962976 ZNF324B 0.46 6.13 0.35 3.11e-9 Uric acid clearance; CESC cis rs11792861 0.926 rs56899598 chr9:111867271 A/G cg05043794 chr9:111880884 C9orf5 -0.41 -6.88 -0.39 4.29e-11 Menarche (age at onset); CESC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg27266027 chr21:40555129 PSMG1 0.41 5.22 0.31 3.62e-7 Cognitive function; CESC cis rs765787 0.530 rs12440321 chr15:45529385 G/A cg24006582 chr15:45444508 DUOX1 0.57 6.94 0.39 3.04e-11 Uric acid levels; CESC cis rs34779708 0.931 rs4934720 chr10:35376800 T/C cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24809958 chr1:6662478 KLHL21 -0.43 -6.2 -0.36 2.12e-9 Gambling; CESC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.43 -5.81 -0.34 1.8e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7020830 0.858 rs1492714 chr9:37141259 T/C cg14294708 chr9:37120828 ZCCHC7 1.25 25.19 0.84 2.66e-72 Schizophrenia; CESC cis rs854765 0.693 rs11657074 chr17:17770355 G/A cg04398451 chr17:18023971 MYO15A 0.63 9.0 0.48 4.49e-17 Total body bone mineral density; CESC cis rs362272 0.524 rs6819202 chr4:3368264 G/A cg14583973 chr4:3374767 RGS12 0.31 5.43 0.32 1.29e-7 Serum sulfate level; CESC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg01988459 chr11:68622903 NA -0.42 -5.74 -0.33 2.58e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs561341 1.000 rs564714 chr17:30318404 C/T cg20587970 chr11:113659929 NA -1.48 -19.58 -0.77 2.15e-53 Hip circumference adjusted for BMI; CESC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg17746819 chr1:100715586 DBT 0.49 6.96 0.39 2.65e-11 Response to TNF-alpha inhibitors in rheumatoid arthritis; CESC cis rs17253792 0.822 rs10147688 chr14:56054642 T/C cg01858014 chr14:56050164 KTN1 -0.82 -6.43 -0.37 5.88e-10 Putamen volume; CESC cis rs3820928 1.000 rs10167422 chr2:227777554 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.81 -0.34 1.74e-8 Pulmonary function; CESC cis rs763014 0.931 rs11648728 chr16:635525 C/T cg09263875 chr16:632152 PIGQ 0.68 11.61 0.58 1.81e-25 Height; CESC cis rs11098499 0.863 rs34868248 chr4:120442430 A/G cg09307838 chr4:120376055 NA 0.92 12.64 0.61 5.65e-29 Corneal astigmatism; CESC cis rs1048238 0.846 rs945417 chr1:16344625 C/G cg22431228 chr1:16359049 CLCNKA -0.55 -11.0 -0.56 2.02e-23 Systolic blood pressure; CESC cis rs13095912 1.000 rs13095912 chr3:185302098 G/A cg11274856 chr3:185301563 NA 0.37 5.88 0.34 1.22e-8 Systolic blood pressure; CESC cis rs7149242 0.696 rs7141210 chr14:101182470 T/C cg18089426 chr14:101175970 NA -0.4 -6.65 -0.38 1.65e-10 Platelet count; CESC cis rs6963495 0.556 rs711433 chr7:105153191 A/G cg19920283 chr7:105172520 RINT1 -0.52 -6.05 -0.35 4.89e-9 Bipolar disorder (body mass index interaction); CESC cis rs7762018 0.770 rs3823466 chr6:170189926 C/T cg05834625 chr6:170176447 C6orf70 0.59 6.71 0.38 1.17e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs10880689 1 rs10880689 chr12:37930102 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.78 0.33 2.05e-8 Resting heart rate; CESC trans rs9325144 0.723 rs11169482 chr12:39164327 A/T cg23762105 chr12:34175262 ALG10 -0.46 -6.02 -0.35 5.8e-9 Morning vs. evening chronotype; CESC cis rs7618915 0.501 rs55678971 chr3:52717229 T/A cg18404041 chr3:52824283 ITIH1 -0.41 -6.88 -0.39 4.35e-11 Bipolar disorder; CESC cis rs2235642 0.893 rs2076442 chr16:1591112 G/T cg08296037 chr16:1584118 IFT140;TMEM204 -0.36 -5.88 -0.34 1.25e-8 Coronary artery disease; CESC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.38 -0.31 1.61e-7 Total body bone mineral density; CESC cis rs3768617 0.528 rs3736888 chr1:183084607 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.49e-35 Fuchs's corneal dystrophy; CESC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg13628971 chr7:2884303 GNA12 0.64 8.78 0.47 2.11e-16 Height; CESC cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4689388 0.890 rs13130845 chr4:6297646 A/C cg25554036 chr4:6271136 WFS1 0.52 8.38 0.46 3.1e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs3008870 1.000 rs2065001 chr1:67486509 C/G cg11518657 chr1:67396239 MIER1 0.48 5.07 0.3 7.66e-7 Lymphocyte percentage of white cells; CESC cis rs9291683 0.554 rs7668175 chr4:10125782 T/C cg00071950 chr4:10020882 SLC2A9 -0.56 -8.54 -0.46 1.07e-15 Bone mineral density; CESC cis rs34638657 0.753 rs2967375 chr16:82211418 A/G cg09439754 chr16:82129088 HSD17B2 -0.34 -5.68 -0.33 3.61e-8 Lung adenocarcinoma; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20505218 chr17:80009845 GPS1;RFNG -0.51 -6.88 -0.39 4.32e-11 Height; CESC cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg23711669 chr6:146136114 FBXO30 1.0 15.5 0.69 5.39e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs7605827 0.897 rs6745917 chr2:15537924 G/C cg19274914 chr2:15703543 NA 0.35 6.16 0.35 2.66e-9 Educational attainment (years of education); CESC cis rs4727027 0.899 rs6944096 chr7:148870026 A/G cg23583168 chr7:148888333 NA -0.87 -14.12 -0.66 3.93e-34 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs12477438 0.520 rs6712704 chr2:99719687 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.87 0.7 2.48e-40 Chronic sinus infection; CESC cis rs921968 0.565 rs6436086 chr2:219640125 T/C cg02176678 chr2:219576539 TTLL4 -0.43 -7.66 -0.43 3.42e-13 Mean corpuscular hemoglobin concentration; CESC cis rs3857536 0.813 rs6903678 chr6:66931208 C/T cg07460842 chr6:66804631 NA 0.38 5.06 0.3 7.87e-7 Blood trace element (Cu levels); CESC cis rs9388451 0.839 rs1811852 chr6:126071575 G/C cg05901451 chr6:126070800 HEY2 -0.64 -9.11 -0.49 2.09e-17 Brugada syndrome; CESC cis rs4727027 0.933 rs7788925 chr7:148831621 A/G cg23158103 chr7:148848205 ZNF398 -0.4 -6.51 -0.37 3.67e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg03806693 chr22:41940476 POLR3H -1.21 -15.42 -0.69 9.91e-39 Vitiligo; CESC cis rs1348850 0.526 rs59972556 chr2:178399561 A/G cg23306229 chr2:178417860 TTC30B 0.81 7.47 0.42 1.14e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs56399783 0.901 rs11761804 chr7:2792524 C/T cg19731401 chr7:2775893 GNA12 0.64 5.73 0.33 2.76e-8 Childhood ear infection; CESC cis rs9916302 0.904 rs3744348 chr17:37417575 C/G cg07936489 chr17:37558343 FBXL20 -0.77 -10.97 -0.56 2.56e-23 Glomerular filtration rate (creatinine); CESC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg17372223 chr3:52568218 NT5DC2 0.35 5.17 0.3 4.62e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg08859206 chr1:53392774 SCP2 0.6 8.93 0.48 7.22e-17 Monocyte count; CESC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg04414720 chr1:150670196 GOLPH3L 0.51 6.76 0.38 8.61e-11 Melanoma; CESC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg06600287 chr1:53387719 ECHDC2 -0.29 -5.06 -0.3 7.92e-7 Monocyte count; CESC cis rs9287719 0.967 rs7563894 chr2:10754649 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs28374715 0.580 rs8030228 chr15:41636867 A/G cg02330683 chr15:41787940 ITPKA 0.46 5.83 0.34 1.6e-8 Ulcerative colitis; CESC cis rs35110281 0.744 rs230646 chr21:44918788 A/G cg04455712 chr21:45112962 RRP1B 0.35 5.21 0.3 3.76e-7 Mean corpuscular volume; CESC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 1.000 rs2769347 chr6:167371737 T/A cg07741184 chr6:167504864 NA -0.3 -5.42 -0.32 1.34e-7 Crohn's disease; CESC cis rs17376456 0.825 rs35496867 chr5:93220400 T/C cg25358565 chr5:93447407 FAM172A 1.09 10.27 0.53 4.95e-21 Diabetic retinopathy; CESC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg17724175 chr1:150552817 MCL1 0.38 5.96 0.34 8.07e-9 Melanoma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09270951 chr12:4647414 C12orf4;RAD51AP1 0.44 6.25 0.36 1.65e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.73 0.47 2.94e-16 Colonoscopy-negative controls vs population controls; CESC trans rs724568 0.642 rs7593116 chr2:67927023 G/A cg19718508 chr5:176831858 F12 -0.45 -6.33 -0.36 1.06e-9 Major depressive disorder (broad); CESC cis rs2408955 0.541 rs11168428 chr12:48547128 A/G cg04545296 chr12:48745243 ZNF641 -0.35 -5.97 -0.34 7.77e-9 Glycated hemoglobin levels; CESC cis rs12681366 0.734 rs6991077 chr8:95387805 C/T cg13257157 chr8:95487014 RAD54B 0.39 5.26 0.31 3.04e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7949030 0.588 rs2512562 chr11:62312156 A/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.42 -0.32 1.37e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg15017067 chr4:17643749 FAM184B 0.39 5.67 0.33 3.76e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11330941 chr2:17934879 GEN1;SMC6 -0.58 -6.57 -0.37 2.64e-10 Gut microbiome composition (summer); CESC cis rs6032067 0.632 rs35361894 chr20:43794403 G/A cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg05025164 chr4:1340916 KIAA1530 0.87 11.81 0.59 3.81e-26 Longevity; CESC cis rs763121 0.853 rs2413547 chr22:39107338 A/G cg06022373 chr22:39101656 GTPBP1 0.91 14.57 0.67 9.91e-36 Menopause (age at onset); CESC cis rs7605827 0.930 rs7598068 chr2:15596535 A/T cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg11965913 chr1:205819406 PM20D1 0.83 13.51 0.64 5.44e-32 Menarche (age at onset); CESC cis rs9910055 0.573 rs113184718 chr17:42206543 A/T cg19774624 chr17:42201019 HDAC5 0.83 13.02 0.62 2.7e-30 Total body bone mineral density; CESC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg13770153 chr20:60521292 NA -0.44 -5.7 -0.33 3.2e-8 Body mass index; CESC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg11890956 chr21:40555474 PSMG1 1.15 21.07 0.79 1.46e-58 Cognitive function; CESC cis rs3091242 0.933 rs28530483 chr1:25740847 A/C cg03538708 chr1:25844672 NA -0.4 -5.86 -0.34 1.41e-8 Erythrocyte sedimentation rate; CESC cis rs897984 0.568 rs8050107 chr16:30893451 C/T cg02466173 chr16:30829666 NA 0.44 6.27 0.36 1.44e-9 Dementia with Lewy bodies; CESC cis rs9916302 0.851 rs9904919 chr17:37556431 G/C cg20243544 chr17:37824526 PNMT -0.49 -6.22 -0.36 1.94e-9 Glomerular filtration rate (creatinine); CESC cis rs12477438 0.798 rs12473029 chr2:99637961 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.6 -0.55 4.17e-22 Chronic sinus infection; CESC trans rs208515 0.525 rs10755508 chr6:66675790 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.9 0.56 4.24e-23 Exhaled nitric oxide levels; CESC cis rs1577917 0.785 rs1885607 chr6:86394905 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.56 7.78 0.43 1.59e-13 Response to antipsychotic treatment; CESC cis rs3733585 0.673 rs7375587 chr4:9954758 A/T cg11266682 chr4:10021025 SLC2A9 0.58 10.96 0.56 2.77e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg25072359 chr17:41440525 NA 0.48 6.35 0.36 9.3e-10 Menopause (age at onset); CESC trans rs66573146 0.634 rs56097119 chr4:7018692 C/G cg07817883 chr1:32538562 TMEM39B 0.94 6.16 0.35 2.69e-9 Granulocyte percentage of myeloid white cells; CESC trans rs6934970 0.932 rs12201407 chr6:113144268 G/T cg13507084 chr9:34555042 CNTFR -0.48 -6.18 -0.35 2.45e-9 Bipolar disorder (body mass index interaction); CESC cis rs8114671 0.562 rs2889861 chr20:33405664 C/T cg24642439 chr20:33292090 TP53INP2 0.44 5.34 0.31 2.02e-7 Height; CESC cis rs919433 0.929 rs10931779 chr2:198166825 A/G cg03934865 chr2:198174659 NA -0.48 -7.66 -0.43 3.54e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs9975691 1 rs9975691 chr21:14928355 G/T cg03180457 chr10:43133994 ZNF33B 0.47 6.04 0.35 5.16e-9 Neurofibrillary tangles; CESC cis rs12425451 0.544 rs3741951 chr12:3147080 A/G cg05389053 chr12:3131226 TEAD4 0.52 5.71 0.33 3.01e-8 Narcolepsy with cataplexy; CESC cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.4 6.7 0.38 1.28e-10 Hemoglobin concentration; CESC cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.21e-7 Colonoscopy-negative controls vs population controls; CESC trans rs73568641 0.583 rs4870224 chr6:154104380 A/G cg08374472 chr16:87445639 ZCCHC14 0.44 6.01 0.35 6.19e-9 Methadone dose in opioid dependence; CESC cis rs7692995 1.000 rs12511600 chr4:17939921 C/T cg08925142 chr4:18023851 LCORL -0.45 -5.3 -0.31 2.5e-7 Height; CESC cis rs16867321 0.627 rs13400001 chr2:181589205 T/C cg23363182 chr2:181467187 NA -0.44 -5.74 -0.33 2.59e-8 Obesity; CESC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg25036284 chr2:26402008 FAM59B -0.59 -6.88 -0.39 4.37e-11 Gut microbiome composition (summer); CESC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg22963979 chr7:1858916 MAD1L1 -0.39 -5.42 -0.32 1.36e-7 Bipolar disorder and schizophrenia; CESC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg18016565 chr1:150552671 MCL1 0.34 5.28 0.31 2.67e-7 Tonsillectomy; CESC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg22968622 chr17:43663579 NA -1.19 -16.28 -0.71 8.87e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs735396 0.694 rs2264750 chr12:121450165 C/T cg02403541 chr12:121454288 C12orf43 0.73 10.08 0.53 1.87e-20 N-glycan levels; CESC cis rs6987853 0.830 rs4737048 chr8:42359035 G/T cg09913449 chr8:42400586 C8orf40 -0.34 -5.3 -0.31 2.41e-7 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18295152 chr5:157170440 LSM11 -0.57 -6.14 -0.35 3.06e-9 Gut microbiome composition (summer); CESC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg03452623 chr4:187889614 NA -0.84 -13.73 -0.64 9.22e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg08923669 chr16:420230 MRPL28 -0.43 -5.04 -0.3 8.76e-7 Bone mineral density (spine);Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25228510 chr10:62538235 CDK1;CDC2 0.53 6.22 0.36 1.97e-9 Gut microbiome composition (summer); CESC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg14159672 chr1:205819179 PM20D1 0.4 5.21 0.3 3.81e-7 Parkinson's disease; CESC cis rs7107174 0.892 rs2510038 chr11:77966034 C/T cg02023728 chr11:77925099 USP35 0.42 5.53 0.32 7.84e-8 Testicular germ cell tumor; CESC cis rs2290720 0.965 rs7313828 chr12:101722005 A/C cg22051763 chr12:101673672 UTP20 -0.46 -5.47 -0.32 1.05e-7 Brain structure (hippocampal volume); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02292671 chr10:6244643 PFKFB3 0.61 6.84 0.39 5.55e-11 Gut microbiome composition (summer); CESC cis rs7617480 0.648 rs10865953 chr3:48759562 C/T cg07636037 chr3:49044803 WDR6 0.79 10.38 0.54 2.06e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg07167872 chr1:205819463 PM20D1 0.42 6.42 0.37 6.43e-10 Menarche (age at onset); CESC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg18876405 chr7:65276391 NA -0.56 -7.69 -0.43 2.94e-13 Aortic root size; CESC cis rs2777491 1.000 rs316605 chr15:41771591 G/A cg02330683 chr15:41787940 ITPKA 0.48 7.14 0.4 9.19e-12 Ulcerative colitis; CESC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg17294928 chr15:75287854 SCAMP5 0.49 6.17 0.35 2.54e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs4423214 0.592 rs7130829 chr11:71237702 A/T cg05163923 chr11:71159392 DHCR7 -0.54 -5.84 -0.34 1.55e-8 Vitamin D levels; CESC cis rs7474896 0.583 rs4934898 chr10:37990395 G/C cg25427524 chr10:38739819 LOC399744 -0.47 -5.44 -0.32 1.24e-7 Obesity (extreme); CESC cis rs1018836 0.608 rs6998106 chr8:91479755 G/T cg16814680 chr8:91681699 NA -0.56 -7.74 -0.43 2.08e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC cis rs2576037 0.526 rs564113 chr18:44364389 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.7 10.89 0.56 4.41e-23 Personality dimensions; CESC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs2000999 0.524 rs12933482 chr16:72189604 A/G cg04254540 chr16:71951199 KIAA0174 -0.74 -6.04 -0.35 5.25e-9 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC cis rs3820068 0.705 rs57971278 chr1:15838604 G/A cg18192808 chr1:15853278 DNAJC16 0.47 5.63 0.33 4.47e-8 Systolic blood pressure; CESC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg13647721 chr17:30228624 UTP6 0.59 5.28 0.31 2.69e-7 Hip circumference adjusted for BMI; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16638425 chr16:2946805 FLYWCH2 0.46 6.65 0.38 1.7e-10 Fibrinogen levels; CESC cis rs4423214 1.000 rs2282620 chr11:71183477 C/T cg05163923 chr11:71159392 DHCR7 0.82 10.82 0.55 7.47e-23 Vitamin D levels; CESC cis rs911555 0.692 rs60235428 chr14:103904350 T/C cg24130564 chr14:104152367 KLC1 0.5 6.5 0.37 3.98e-10 Intelligence (multi-trait analysis); CESC cis rs13191362 0.507 rs2846536 chr6:163033492 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.47 5.84 0.34 1.56e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs9768139 0.708 rs896780 chr7:158113972 C/T cg24154853 chr7:158122151 PTPRN2 0.42 6.48 0.37 4.38e-10 Calcium levels; CESC cis rs1881797 1.000 rs68059491 chr1:247683070 C/T cg21399703 chr1:247681439 NA 0.61 7.8 0.43 1.41e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs4865169 0.934 rs12650737 chr4:57892475 G/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.37 -5.07 -0.3 7.58e-7 Breast cancer; CESC cis rs10752881 0.967 rs8179284 chr1:182974707 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Colorectal cancer; CESC cis rs9457247 1.000 rs422094 chr6:167397033 C/G cg25258033 chr6:167368657 RNASET2 0.4 5.95 0.34 8.36e-9 Crohn's disease; CESC cis rs11098499 0.863 rs3775845 chr4:120432447 T/C cg24375607 chr4:120327624 NA 0.44 5.25 0.31 3.06e-7 Corneal astigmatism; CESC cis rs1348850 0.958 rs10497501 chr2:178462299 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.62 0.47 6.11e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs644799 0.862 rs1150361 chr11:95633805 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.84 12.44 0.61 2.7e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2573652 1.000 rs12440866 chr15:100517010 G/A cg09918751 chr15:100517450 ADAMTS17 -0.4 -7.66 -0.43 3.52e-13 Height; CESC cis rs28489187 0.706 rs233066 chr1:85804930 T/C cg16011679 chr1:85725395 C1orf52 0.54 6.24 0.36 1.7e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26156301 chr20:30193024 ID1 0.6 6.47 0.37 4.8e-10 Gut microbiome composition (summer); CESC cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg01475377 chr6:109611718 NA -0.42 -6.43 -0.37 6.01e-10 Reticulocyte fraction of red cells; CESC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.79 6.4 0.37 7.1e-10 Platelet count; CESC cis rs7917772 0.582 rs4919661 chr10:104358403 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.63 0.33 4.48e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7296418 0.630 rs11608305 chr12:123791165 C/G cg05973401 chr12:123451056 ABCB9 0.44 5.57 0.32 6.33e-8 Platelet count; CESC cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg19482086 chr6:160211437 TCP1;MRPL18 0.75 9.5 0.5 1.27e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg20891283 chr12:69753455 YEATS4 1.0 17.3 0.73 2.24e-45 Cerebrospinal fluid biomarker levels; CESC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg02569458 chr12:86230093 RASSF9 0.51 7.8 0.43 1.4e-13 Major depressive disorder; CESC cis rs7208859 0.623 rs56812022 chr17:29068733 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.15 0.3 5.11e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2797160 0.905 rs1418641 chr6:125999854 C/T cg05901451 chr6:126070800 HEY2 -0.45 -6.67 -0.38 1.44e-10 Endometrial cancer; CESC cis rs9486719 1.000 rs10872018 chr6:97026429 G/A cg18709589 chr6:96969512 KIAA0776 -0.5 -5.43 -0.32 1.28e-7 Migraine;Coronary artery disease; CESC cis rs3540 0.597 rs11639150 chr15:91042071 C/G cg22089800 chr15:90895588 ZNF774 -0.64 -8.78 -0.47 2.11e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg01475377 chr6:109611718 NA -0.42 -6.4 -0.37 6.83e-10 Reticulocyte fraction of red cells; CESC cis rs4132509 0.625 rs1058304 chr1:243664857 C/T cg21452805 chr1:244014465 NA 0.4 5.19 0.3 4.23e-7 RR interval (heart rate); CESC cis rs2247341 0.965 rs2854920 chr4:1715349 C/T cg07465881 chr4:1713556 SLBP -0.52 -6.42 -0.37 6.44e-10 Hip circumference adjusted for BMI;Height; CESC cis rs5758659 0.652 rs133358 chr22:42442539 A/T cg04733989 chr22:42467013 NAGA 0.46 6.44 0.37 5.61e-10 Cognitive function; CESC cis rs1034435 0.692 rs6008739 chr22:48892542 T/C cg05992904 chr22:48892994 FAM19A5 -0.56 -9.87 -0.52 8.9e-20 Late-onset Alzheimer's disease; CESC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg26441486 chr22:50317300 CRELD2 0.41 5.22 0.31 3.7e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25151688 chr15:66585534 DIS3L -0.54 -6.45 -0.37 5.17e-10 Gut microbiome composition (summer); CESC cis rs6987853 0.583 rs2974311 chr8:42455166 G/A cg09913449 chr8:42400586 C8orf40 0.34 5.22 0.31 3.58e-7 Mean corpuscular hemoglobin concentration; CESC cis rs4664304 0.629 rs57751799 chr2:160854180 A/T cg03641300 chr2:160917029 PLA2R1 -0.43 -5.81 -0.34 1.78e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs35955747 0.902 rs713947 chr22:31639509 G/T cg25791279 chr22:32026902 PISD -0.49 -5.87 -0.34 1.28e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs12701220 0.817 rs59471534 chr7:1085224 G/A cg26769984 chr7:1090371 C7orf50 0.56 6.87 0.39 4.63e-11 Bronchopulmonary dysplasia; CESC cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg04025307 chr7:1156635 C7orf50 0.46 5.18 0.3 4.46e-7 Bronchopulmonary dysplasia; CESC cis rs763014 0.931 rs1981483 chr16:630665 G/A cg07256732 chr16:621771 PIGQ -0.31 -5.38 -0.31 1.61e-7 Height; CESC cis rs2075371 0.611 rs34573600 chr7:134018937 C/T cg11752832 chr7:134001865 SLC35B4 0.42 5.08 0.3 7.08e-7 Mean platelet volume; CESC cis rs780096 0.526 rs11682621 chr2:27749669 G/A cg22903471 chr2:27725779 GCKR -0.52 -7.22 -0.41 5.45e-12 Total body bone mineral density; CESC cis rs11637445 0.627 rs72751453 chr15:68124665 C/A cg08079166 chr15:68083412 MAP2K5 -0.35 -5.05 -0.3 8.18e-7 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs4803468 1.000 rs10417311 chr19:41902038 G/A cg08477640 chr19:41863820 B9D2 0.38 5.07 0.3 7.53e-7 Height; CESC trans rs208520 0.954 rs1468153 chr6:67009054 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 7.46 0.42 1.25e-12 Exhaled nitric oxide output; CESC trans rs11989868 1.000 rs920614 chr8:14543523 C/T cg22006392 chr17:927457 ABR -0.43 -6.0 -0.35 6.42e-9 Obesity-related traits; CESC cis rs2559856 1.000 rs2559857 chr12:102089399 A/C cg15068132 chr12:102092402 CHPT1 -0.43 -5.64 -0.33 4.26e-8 Blood protein levels; CESC cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg10523679 chr1:76189770 ACADM -0.87 -13.69 -0.64 1.22e-32 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7312774 0.748 rs1861745 chr12:107301642 C/T cg16260113 chr12:107380972 MTERFD3 0.71 6.39 0.37 7.64e-10 Severe influenza A (H1N1) infection; CESC cis rs2857078 0.745 rs4793085 chr17:42320732 A/C cg19774624 chr17:42201019 HDAC5 0.54 7.32 0.41 2.91e-12 Red cell distribution width;Reticulocyte count; CESC cis rs6433857 0.536 rs1901750 chr2:181350739 C/T cg23363182 chr2:181467187 NA -0.41 -5.91 -0.34 1.05e-8 Body mass index; CESC cis rs1348850 0.632 rs1358328 chr2:178517532 G/A cg23306229 chr2:178417860 TTC30B 0.57 6.96 0.39 2.61e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11098499 0.908 rs12504149 chr4:120318577 G/A cg24375607 chr4:120327624 NA 0.47 5.73 0.33 2.74e-8 Corneal astigmatism; CESC cis rs7818382 0.967 rs7812465 chr8:96050557 C/T cg09323728 chr8:95962352 TP53INP1 0.34 7.44 0.42 1.44e-12 Alzheimer's disease (late onset); CESC trans rs116095464 0.558 rs59284383 chr5:284525 C/G cg00938859 chr5:1591904 SDHAP3 0.65 7.03 0.4 1.73e-11 Breast cancer; CESC cis rs7666738 0.830 rs28878289 chr4:98855181 C/T cg03467027 chr4:99064603 C4orf37 0.42 5.16 0.3 4.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.691 rs11211174 chr1:46220816 C/G cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14634842 chr2:232574012 PTMA -0.49 -6.55 -0.37 3.03e-10 Asthma; CESC cis rs6087990 1.000 rs2424900 chr20:31344342 G/C cg13636640 chr20:31349939 DNMT3B 0.91 16.04 0.7 6.22e-41 Ulcerative colitis; CESC cis rs9858542 0.953 rs9814873 chr3:49454112 A/G cg03060546 chr3:49711283 APEH -0.5 -5.99 -0.35 6.65e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs10463316 0.894 rs7707745 chr5:150765198 G/T cg03212797 chr5:150827313 SLC36A1 -0.44 -5.7 -0.33 3.24e-8 Metabolite levels (Pyroglutamine); CESC cis rs7089973 0.604 rs61596353 chr10:116597763 T/C cg25233709 chr10:116636983 FAM160B1 0.38 5.97 0.34 7.44e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4073582 0.595 rs801736 chr11:65928430 A/T cg14036092 chr11:66035641 RAB1B 0.54 7.56 0.42 6.63e-13 Gout; CESC trans rs1373453 0.808 rs78879958 chr12:70071943 A/C cg19702771 chr4:82058885 PRKG2 0.74 6.01 0.35 6.27e-9 Orofacial clefts; CESC trans rs3942852 0.774 rs924715 chr11:48181060 G/A cg15704280 chr7:45808275 SEPT13 -0.73 -8.22 -0.45 9.33e-15 Acute lymphoblastic leukemia (childhood); CESC cis rs8068544 0.748 rs75881902 chr17:40156612 C/A cg26502583 chr17:39992600 KLHL10;NT5C3L -0.76 -6.07 -0.35 4.34e-9 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs113835537 0.597 rs3737525 chr11:66306355 A/G cg24851651 chr11:66362959 CCS 0.55 6.38 0.36 7.96e-10 Airway imaging phenotypes; CESC cis rs6964587 1.000 rs11971885 chr7:91674807 T/C cg17063962 chr7:91808500 NA 0.59 7.96 0.44 5.09e-14 Breast cancer; CESC cis rs10823500 0.748 rs12355080 chr10:71963608 G/A cg02100629 chr10:71892760 AIFM2 -0.32 -5.09 -0.3 6.83e-7 Blood protein levels; CESC cis rs2243480 1.000 rs4718334 chr7:65789454 G/A cg13147721 chr7:65941812 NA 0.92 9.04 0.49 3.39e-17 Diabetic kidney disease; CESC cis rs13191362 0.507 rs13197051 chr6:163201728 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.47 5.53 0.32 7.67e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg11890956 chr21:40555474 PSMG1 -0.96 -15.96 -0.7 1.18e-40 Cognitive function; CESC cis rs1670533 0.697 rs658846 chr4:1084723 G/C cg27284194 chr4:1044797 NA 0.52 5.79 0.34 1.99e-8 Recombination rate (females); CESC cis rs2295499 0.553 rs10937922 chr4:2682663 C/T cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.24 -0.31 3.26e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.16 0.45 1.32e-14 Menopause (age at onset); CESC cis rs12410462 0.892 rs75757169 chr1:227629855 A/G cg04117972 chr1:227635322 NA 0.64 6.48 0.37 4.36e-10 Major depressive disorder; CESC cis rs11958404 1.000 rs72816529 chr5:157411454 G/C cg05962755 chr5:157440814 NA 0.62 6.42 0.37 6.09e-10 IgG glycosylation; CESC cis rs9796 0.689 rs8032195 chr15:41448790 G/A cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.88 -0.39 4.31e-11 Menopause (age at onset); CESC cis rs911555 0.755 rs8014013 chr14:103937372 A/G cg12935359 chr14:103987150 CKB 0.64 9.14 0.49 1.67e-17 Intelligence (multi-trait analysis); CESC cis rs3806843 0.735 rs2530241 chr5:140054485 C/T cg26395211 chr5:140044315 WDR55 0.47 5.99 0.35 6.69e-9 Depressive symptoms (multi-trait analysis); CESC cis rs6582630 0.519 rs80226845 chr12:38528231 C/A cg26384229 chr12:38710491 ALG10B 0.71 10.89 0.56 4.51e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs12479064 0.724 rs3792143 chr2:100057020 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.44 -0.42 1.4e-12 Chronic sinus infection; CESC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg00166722 chr3:10149974 C3orf24 0.5 6.2 0.36 2.2e-9 Alzheimer's disease; CESC cis rs782590 0.967 rs17798852 chr2:55805172 A/C cg18811423 chr2:55921094 PNPT1 0.78 12.57 0.61 1e-28 Metabolic syndrome; CESC cis rs3820068 0.705 rs6656907 chr1:15896984 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.78 0.33 2.12e-8 Systolic blood pressure; CESC cis rs12900413 0.687 rs12911196 chr15:90310734 G/C cg24249390 chr15:90295951 MESP1 -0.4 -5.55 -0.32 6.91e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.83 0.34 1.6e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4927850 0.709 rs6765762 chr3:195652851 G/A cg12923728 chr3:195709715 SDHAP1 -0.66 -7.81 -0.43 1.33e-13 Pancreatic cancer; CESC cis rs453301 0.682 rs2929451 chr8:9085295 A/T cg15556689 chr8:8085844 FLJ10661 0.52 6.92 0.39 3.43e-11 Joint mobility (Beighton score); CESC trans rs61931739 0.500 rs12371415 chr12:34521362 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.17e-22 Morning vs. evening chronotype; CESC cis rs4803468 1.000 rs6508977 chr19:41909346 A/G cg14132834 chr19:41945861 ATP5SL -0.63 -7.89 -0.44 8.04e-14 Height; CESC cis rs4835473 0.932 rs1988206 chr4:144912497 A/C cg25736465 chr4:144833511 NA 0.43 6.5 0.37 3.87e-10 Immature fraction of reticulocytes; CESC cis rs2204008 0.806 rs3922574 chr12:38329069 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.0 0.35 6.62e-9 Bladder cancer; CESC trans rs8073060 0.544 rs225244 chr17:33946581 A/G cg19694781 chr19:47549865 TMEM160 0.72 6.87 0.39 4.63e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs6662572 0.853 rs2065708 chr1:45977685 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.53 5.74 0.33 2.56e-8 Blood protein levels; CESC cis rs12497850 1.000 rs4858828 chr3:48724811 C/T cg03060546 chr3:49711283 APEH 0.43 5.44 0.32 1.21e-7 Parkinson's disease; CESC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg07701084 chr6:150067640 NUP43 0.44 5.95 0.34 8.59e-9 Lung cancer; CESC trans rs2975734 0.674 rs6983870 chr8:10111294 G/A cg15556689 chr8:8085844 FLJ10661 -0.58 -6.79 -0.38 7.54e-11 Morning vs. evening chronotype;Chronotype; CESC cis rs1355223 0.506 rs7131229 chr11:34869328 A/G cg11058730 chr11:34937778 PDHX;APIP 0.53 6.51 0.37 3.71e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15304497 chr14:75230530 YLPM1 -0.6 -7.22 -0.41 5.64e-12 Gut microbiome composition (summer); CESC trans rs3780486 1.000 rs3780480 chr9:33163486 G/T cg04842962 chr6:43655489 MRPS18A 0.89 13.16 0.63 8.73e-31 IgG glycosylation; CESC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg11168104 chr5:1857477 NA -0.35 -5.1 -0.3 6.38e-7 Cardiovascular disease risk factors; CESC cis rs7605827 0.930 rs3805104 chr2:15535147 C/T cg19274914 chr2:15703543 NA 0.33 5.89 0.34 1.2e-8 Educational attainment (years of education); CESC cis rs2235642 0.505 rs56359342 chr16:1654948 G/A cg03650551 chr16:1797383 MAPK8IP3 -0.39 -5.29 -0.31 2.53e-7 Coronary artery disease; CESC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.18e-7 Aortic root size; CESC cis rs477692 0.563 rs7079165 chr10:131430240 G/A cg05714579 chr10:131428358 MGMT -0.71 -11.32 -0.57 1.73e-24 Response to temozolomide; CESC cis rs9399135 1.000 rs35123050 chr6:135302740 G/A cg24558204 chr6:135376177 HBS1L 0.5 6.68 0.38 1.37e-10 Red blood cell count; CESC cis rs4835473 0.897 rs6832749 chr4:144630626 C/T cg25736465 chr4:144833511 NA 0.4 6.09 0.35 3.86e-9 Immature fraction of reticulocytes; CESC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg22535103 chr8:58192502 C8orf71 -0.69 -8.5 -0.46 1.35e-15 Developmental language disorder (linguistic errors); CESC trans rs9858542 0.953 rs3811697 chr3:49590770 C/T cg21659725 chr3:3221576 CRBN -0.52 -6.43 -0.37 5.93e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.5 -5.96 -0.34 8.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg09509183 chr1:209979624 IRF6 0.56 5.86 0.34 1.4e-8 Cleft lip with or without cleft palate; CESC cis rs6580649 0.941 rs72644845 chr12:48503881 G/A cg05342945 chr12:48394962 COL2A1 0.55 6.32 0.36 1.13e-9 Lung cancer; CESC cis rs34779708 0.966 rs34296409 chr10:35404613 C/G cg03585969 chr10:35415529 CREM 0.77 10.1 0.53 1.71e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs61931739 0.817 rs10743841 chr12:34252870 T/C cg19457237 chr12:34500585 NA -0.39 -5.54 -0.32 7.24e-8 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg03676636 chr4:99064102 C4orf37 0.33 5.03 0.3 8.89e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 0.602 rs12209395 chr6:167463914 C/T cg07741184 chr6:167504864 NA 0.36 6.46 0.37 4.92e-10 Crohn's disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14610884 chr6:116575311 TSPYL4 -0.44 -6.02 -0.35 5.78e-9 Asthma; CESC cis rs1558375 0.679 rs31671 chr7:87059403 C/G cg00919237 chr7:87102261 ABCB4 -0.4 -5.6 -0.33 5.39e-8 Gallbladder cancer; CESC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg14393609 chr7:65229607 NA 0.48 6.5 0.37 4e-10 Aortic root size; CESC cis rs3733585 0.673 rs7376505 chr4:9952744 C/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.43e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg07701084 chr6:150067640 NUP43 0.46 6.49 0.37 4.23e-10 Lung cancer; CESC cis rs9399135 0.935 rs11759999 chr6:135370495 G/T cg24558204 chr6:135376177 HBS1L 0.51 6.94 0.39 3.01e-11 Red blood cell count; CESC trans rs1908814 0.516 rs56102998 chr8:11796675 G/A cg15556689 chr8:8085844 FLJ10661 0.52 6.37 0.36 8.4e-10 Neuroticism; CESC cis rs778371 0.874 rs938575 chr2:233768788 G/A cg08000102 chr2:233561755 GIGYF2 -0.82 -10.68 -0.55 2.16e-22 Schizophrenia; CESC trans rs11098499 0.566 rs7664440 chr4:120578540 A/G cg25214090 chr10:38739885 LOC399744 0.61 8.05 0.44 2.83e-14 Corneal astigmatism; CESC cis rs7923609 0.967 rs10509186 chr10:65207018 C/T cg01631684 chr10:65280961 REEP3 -0.43 -5.39 -0.31 1.55e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg07256732 chr16:621771 PIGQ -0.31 -5.4 -0.31 1.48e-7 Height; CESC cis rs11098499 0.863 rs28718422 chr4:120466304 C/A cg24375607 chr4:120327624 NA 0.44 5.36 0.31 1.84e-7 Corneal astigmatism; CESC trans rs875971 0.660 rs801211 chr7:66015689 T/G cg26939375 chr7:64535504 NA -0.64 -8.7 -0.47 3.62e-16 Aortic root size; CESC cis rs35110281 0.774 rs162344 chr21:44954522 G/A cg01579765 chr21:45077557 HSF2BP -0.55 -9.46 -0.5 1.75e-18 Mean corpuscular volume; CESC cis rs17376456 0.825 rs17372725 chr5:93135588 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.26 0.31 3.01e-7 Diabetic retinopathy; CESC cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg05340658 chr4:99064831 C4orf37 0.59 7.9 0.44 7.64e-14 Colonoscopy-negative controls vs population controls; CESC cis rs8017423 0.967 rs12896540 chr14:90729392 T/C cg14092571 chr14:90743983 NA 0.55 8.12 0.45 1.74e-14 Mortality in heart failure; CESC cis rs72945132 0.882 rs7114200 chr11:70186099 C/A cg14191688 chr11:70257035 CTTN 0.44 5.34 0.31 2.01e-7 Coronary artery disease; CESC cis rs561341 1.000 rs501312 chr17:30329066 A/G cg12193833 chr17:30244370 NA -0.73 -6.71 -0.38 1.14e-10 Hip circumference adjusted for BMI; CESC cis rs34734847 0.703 rs3794215 chr12:121168083 T/C cg21892295 chr12:121157589 UNC119B -0.36 -5.86 -0.34 1.34e-8 Mean corpuscular volume; CESC cis rs6570726 0.875 rs1883407 chr6:145823432 T/C cg05347473 chr6:146136440 FBXO30 0.42 5.72 0.33 2.93e-8 Lobe attachment (rater-scored or self-reported); CESC trans rs79976124 0.879 rs12214239 chr6:66636059 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 8.2 0.45 1.02e-14 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15991546 chr1:98386723 DPYD -0.48 -6.37 -0.36 8.48e-10 Gut microbiota (bacterial taxa); CESC cis rs7772486 0.790 rs9376971 chr6:146259505 C/T cg05347473 chr6:146136440 FBXO30 -0.55 -7.0 -0.39 2.12e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs8017423 0.935 rs8012303 chr14:90715829 G/A cg14092571 chr14:90743983 NA -0.58 -8.8 -0.48 1.84e-16 Mortality in heart failure; CESC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg11644478 chr21:40555479 PSMG1 -0.8 -11.52 -0.58 3.61e-25 Cognitive function; CESC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg24733560 chr20:60626293 TAF4 0.42 5.94 0.34 9.14e-9 Body mass index; CESC trans rs1728785 1.000 rs1170434 chr16:68606590 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.71 8.42 0.46 2.43e-15 Ulcerative colitis; CESC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg07507251 chr3:52567010 NT5DC2 0.33 5.7 0.33 3.2e-8 Electroencephalogram traits; CESC cis rs9902453 0.934 rs12453172 chr17:28441590 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.73 0.43 2.21e-13 Coffee consumption (cups per day); CESC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3785574 0.962 rs114027117 chr17:61939935 T/A cg06420487 chr17:61919686 SMARCD2 0.41 5.04 0.3 8.43e-7 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07546770 chr5:68665590 RAD17;TAF9 0.48 6.05 0.35 4.9e-9 Gut microbiota (bacterial taxa); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg11289251 chr16:68056774 DDX28;DUS2L -0.46 -6.08 -0.35 4.09e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg07308232 chr7:1071921 C7orf50 -0.39 -5.26 -0.31 2.92e-7 Longevity;Endometriosis; CESC cis rs6762 0.748 rs7928935 chr11:839127 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.68 -8.52 -0.46 1.24e-15 Mean platelet volume; CESC cis rs4568518 0.616 rs17661083 chr7:18004853 C/T cg03009463 chr7:17980271 SNX13 0.4 5.31 0.31 2.35e-7 Measles; CESC cis rs3105593 0.555 rs3098169 chr15:50754339 G/A cg08437265 chr15:50716283 USP8 0.48 6.43 0.37 5.79e-10 QT interval; CESC cis rs1620921 0.505 rs66496533 chr6:161210741 T/C cg01280913 chr6:161186852 NA -0.38 -5.43 -0.32 1.28e-7 Lipoprotein (a) - cholesterol levels; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg13976366 chr11:4414916 TRIM21 0.45 6.17 0.35 2.54e-9 Neuroticism; CESC cis rs3857536 0.813 rs6455091 chr6:66949127 C/G cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs9291683 0.935 rs1860910 chr4:10275470 T/G cg00071950 chr4:10020882 SLC2A9 0.54 8.24 0.45 7.86e-15 Bone mineral density; CESC trans rs11039798 0.588 rs1814768 chr11:48987455 T/C cg15704280 chr7:45808275 SEPT13 0.63 6.7 0.38 1.26e-10 Axial length; CESC cis rs4969178 0.930 rs12601079 chr17:76400329 G/A cg20026190 chr17:76395443 PGS1 0.46 7.35 0.41 2.41e-12 HDL cholesterol levels; CESC cis rs516243 0.871 rs3748687 chr1:10736216 G/A cg02903756 chr1:10750680 CASZ1 -0.41 -5.72 -0.33 2.88e-8 Migraine - clinic-based; CESC cis rs533581 0.866 rs561795 chr16:88970818 A/G cg16701003 chr16:89028210 CBFA2T3 0.5 7.29 0.41 3.54e-12 Social autistic-like traits; CESC cis rs12477438 0.501 rs7608938 chr2:99782226 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.84 0.62 1.16e-29 Chronic sinus infection; CESC trans rs2998286 1.000 rs2998286 chr10:28780373 T/C cg06484274 chr3:142164840 XRN1 0.46 5.99 0.35 6.71e-9 Sum eosinophil basophil counts;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Eosinophil counts; CESC cis rs72945132 0.882 rs12282678 chr11:70152457 G/A cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs1707322 1.000 rs6675222 chr1:46326576 G/T cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9902453 0.791 rs3115100 chr17:28045744 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.15 0.53 1.14e-20 Coffee consumption (cups per day); CESC cis rs7666738 0.791 rs2081621 chr4:98926753 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 8.9e-15 Colonoscopy-negative controls vs population controls; CESC cis rs8017423 0.626 rs8003363 chr14:90826840 T/C cg14092571 chr14:90743983 NA 0.42 6.23 0.36 1.87e-9 Mortality in heart failure; CESC cis rs56046484 0.871 rs34493704 chr15:85558770 A/G cg08123816 chr15:85640762 PDE8A -0.49 -5.77 -0.33 2.16e-8 Testicular germ cell tumor; CESC cis rs6459804 1.000 rs6459805 chr7:157510294 T/C cg05731713 chr7:157510257 PTPRN2 0.41 6.85 0.39 5.2e-11 Bipolar disorder and schizophrenia; CESC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg07507251 chr3:52567010 NT5DC2 0.42 7.2 0.4 6.23e-12 Bipolar disorder; CESC cis rs2249625 0.844 rs2496502 chr6:72885412 G/A cg18830697 chr6:72922368 RIMS1 -0.39 -5.5 -0.32 8.88e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs12824058 0.831 rs7485200 chr12:130811641 C/T cg24838063 chr12:130822603 PIWIL1 0.64 8.69 0.47 3.72e-16 Menopause (age at onset); CESC cis rs4692589 1.000 rs11727880 chr4:170937467 C/T cg19918862 chr4:170955249 NA 0.36 5.65 0.33 4.07e-8 Anxiety disorder; CESC cis rs1670533 0.818 rs6835141 chr4:1070140 G/T cg27284194 chr4:1044797 NA 0.46 5.99 0.35 6.7e-9 Recombination rate (females); CESC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg17178900 chr1:205818956 PM20D1 0.52 7.72 0.43 2.34e-13 Prostate cancer; CESC cis rs2012796 0.872 rs59397507 chr14:81821334 A/G cg02996355 chr14:81879375 NA 0.59 6.97 0.39 2.52e-11 Night sleep phenotypes; CESC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg25072359 chr17:41440525 NA 0.51 6.61 0.38 2.11e-10 Menopause (age at onset); CESC cis rs17818399 0.653 rs34050156 chr2:46777646 A/G cg06386533 chr2:46925753 SOCS5 0.53 5.94 0.34 9.12e-9 Height; CESC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg17376030 chr22:41985996 PMM1 -0.79 -8.34 -0.46 4.18e-15 Vitiligo; CESC trans rs7824557 0.527 rs2572376 chr8:11237756 C/A cg15556689 chr8:8085844 FLJ10661 -0.48 -6.0 -0.35 6.55e-9 Retinal vascular caliber; CESC cis rs782590 0.807 rs782642 chr2:55928444 G/T cg18811423 chr2:55921094 PNPT1 0.82 13.45 0.64 9e-32 Metabolic syndrome; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00098451 chr1:16370634 CLCNKB 0.41 6.38 0.36 7.94e-10 Fibrinogen levels; CESC cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg02297831 chr4:17616191 MED28 0.55 6.92 0.39 3.33e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg22875332 chr1:76189707 ACADM 0.66 7.95 0.44 5.33e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg12292205 chr6:26970375 C6orf41 0.46 5.38 0.31 1.61e-7 Intelligence (multi-trait analysis); CESC cis rs8060686 0.516 rs10852439 chr16:68288331 T/C cg26727032 chr16:67993705 SLC12A4 -0.61 -8.42 -0.46 2.36e-15 HDL cholesterol;Metabolic syndrome; CESC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg00149659 chr3:10157352 C3orf10 0.69 8.09 0.45 2.13e-14 Alzheimer's disease; CESC cis rs7072216 0.727 rs942808 chr10:100168102 C/A cg26618903 chr10:100175079 PYROXD2 -0.36 -5.49 -0.32 9.42e-8 Metabolite levels; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg14549262 chr9:131965232 NA 0.49 6.1 0.35 3.69e-9 Thyroid stimulating hormone; CESC cis rs901683 1.000 rs35131026 chr10:46014759 G/A cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08395899 chr10:12085052 UPF2 -0.72 -8.45 -0.46 1.92e-15 Gut microbiome composition (summer); CESC cis rs7520050 0.966 rs2486447 chr1:46545724 G/A cg03146154 chr1:46216737 IPP -0.43 -5.53 -0.32 7.77e-8 Red blood cell count;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01026192 chr7:2763915 NA -0.62 -7.03 -0.4 1.77e-11 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs7767660 chr6:146436550 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.59 0.38 2.33e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1003719 0.725 rs2187101 chr21:38452379 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.64 0.47 5.58e-16 Eye color traits; CESC cis rs12145833 0.748 rs11807162 chr1:243454680 C/T cg02356786 chr1:243265016 LOC731275 0.59 5.48 0.32 9.79e-8 Obesity (early onset extreme); CESC cis rs2304069 0.954 rs1433010 chr5:149383954 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.89 -11.55 -0.58 2.96e-25 HIV-1 control; CESC cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg02269571 chr22:50332266 NA -0.55 -6.51 -0.37 3.85e-10 Schizophrenia; CESC cis rs760805 1.000 rs11249204 chr1:25261740 C/T cg22509179 chr1:25234806 RUNX3 0.61 8.72 0.47 3.08e-16 Allergic disease (asthma, hay fever or eczema); CESC cis rs62064224 0.748 rs72813015 chr17:30693331 T/C cg09324608 chr17:30823087 MYO1D 0.51 7.71 0.43 2.61e-13 Schizophrenia; CESC cis rs55692411 0.537 rs35375092 chr3:50065274 G/A cg24110177 chr3:50126178 RBM5 -0.44 -5.18 -0.3 4.37e-7 Intelligence (multi-trait analysis); CESC cis rs9291683 0.517 rs11736479 chr4:10017387 G/C cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.14e-46 Bone mineral density; CESC cis rs2204008 0.542 rs34770471 chr12:38009613 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.71 0.55 1.77e-22 Bladder cancer; CESC cis rs9815354 0.767 rs111708447 chr3:41809583 G/A cg03022575 chr3:42003672 ULK4 0.68 6.06 0.35 4.7e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs2280018 0.963 rs11075255 chr16:15166232 A/G cg07549590 chr16:15018862 NA -0.48 -7.73 -0.43 2.19e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24342864 chr17:17184608 COPS3 -0.63 -8.1 -0.45 2.01e-14 Gut microbiome composition (summer); CESC cis rs116095464 1.000 rs6555160 chr5:311669 A/G cg22857025 chr5:266934 NA 1.14 10.04 0.53 2.53e-20 Breast cancer; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg09491787 chr5:139781927 ANKHD1;ANKHD1-EIF4EBP3 0.47 6.05 0.35 4.89e-9 Attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13787782 chr2:239161568 PER2 -0.58 -6.49 -0.37 4.31e-10 Gut microbiome composition (summer); CESC cis rs2204008 0.645 rs9989043 chr12:38238505 G/A cg26384229 chr12:38710491 ALG10B -0.47 -6.14 -0.35 2.95e-9 Bladder cancer; CESC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg03806693 chr22:41940476 POLR3H -1.24 -16.82 -0.72 1.04e-43 Vitiligo; CESC trans rs61931739 0.500 rs35391785 chr12:34444478 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.54 0.54 6.31e-22 Morning vs. evening chronotype; CESC cis rs7917772 0.503 rs7078435 chr10:104304766 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.33 0.41 2.72e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2637266 0.703 rs4437973 chr10:78484971 G/A cg18941641 chr10:78392320 NA 0.4 7.54 0.42 7.54e-13 Pulmonary function; CESC cis rs2228479 0.850 rs62056061 chr16:89901767 G/A cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs853679 1.000 rs853679 chr6:28296863 C/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.68 7.15 0.4 8.65e-12 Depression; CESC trans rs7944735 0.545 rs4752805 chr11:48018355 A/G cg15704280 chr7:45808275 SEPT13 0.68 8.16 0.45 1.33e-14 Intraocular pressure; CESC cis rs2635047 0.600 rs2635056 chr18:44710568 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.59 0.32 5.7e-8 Educational attainment; CESC cis rs3096299 0.934 rs9927904 chr16:89462847 G/A cg16743903 chr16:89593216 SPG7 -0.42 -5.38 -0.31 1.65e-7 Multiple myeloma (IgH translocation); CESC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.21 0.3 3.8e-7 Bipolar disorder; CESC cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg11952622 chr19:58962976 ZNF324B 0.45 5.93 0.34 9.38e-9 Uric acid clearance; CESC cis rs7819412 0.527 rs7821914 chr8:10805015 A/G cg21775007 chr8:11205619 TDH -0.35 -5.13 -0.3 5.68e-7 Triglycerides; CESC cis rs6582618 1 rs6582618 chr12:38726137 A/G cg26384229 chr12:38710491 ALG10B 0.57 8.32 0.46 4.71e-15 Morning vs. evening chronotype; CESC cis rs4969178 0.600 rs4969183 chr17:76393372 A/G cg05887092 chr17:76393375 PGS1 0.68 11.47 0.58 5.58e-25 HDL cholesterol levels; CESC cis rs7267979 1.000 rs6050562 chr20:25336186 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.48 -0.71 1.75e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg00149659 chr3:10157352 C3orf10 0.71 8.62 0.47 6.15e-16 Alzheimer's disease; CESC cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4654899 1.000 rs6663452 chr1:21423154 T/C cg05370193 chr1:21551575 ECE1 0.39 5.95 0.34 8.65e-9 Superior frontal gyrus grey matter volume; CESC trans rs1814175 0.645 rs7119101 chr11:49955665 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg18404041 chr3:52824283 ITIH1 -0.44 -7.31 -0.41 3.24e-12 Bipolar disorder; CESC cis rs796364 0.806 rs188102 chr2:200903189 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.87 -8.14 -0.45 1.58e-14 Schizophrenia; CESC cis rs1882538 0.551 rs6974618 chr7:133084031 C/A cg10665199 chr7:133106180 EXOC4 0.61 8.41 0.46 2.55e-15 Intelligence (multi-trait analysis); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11698762 chr2:74648964 WDR54 0.5 6.75 0.38 9.2e-11 Systemic lupus erythematosus; CESC trans rs79976124 0.837 rs10498840 chr6:66658513 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.81 9.24 0.49 8.29e-18 Type 2 diabetes; CESC cis rs7223966 0.960 rs2319990 chr17:61705397 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.3 0.41 3.26e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7130144 0.541 rs1921572 chr11:130461520 A/G cg26307797 chr11:130446613 NA -0.74 -6.41 -0.37 6.65e-10 Urate levels in lean individuals; CESC cis rs7818345 0.967 rs13255677 chr8:19288985 C/T cg11303988 chr8:19266685 CSGALNACT1 0.33 5.94 0.34 9.12e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg18876405 chr7:65276391 NA 0.73 9.96 0.52 4.56e-20 Aortic root size; CESC trans rs17685 0.671 rs10274404 chr7:75706634 G/A cg19862616 chr7:65841803 NCRNA00174 0.85 12.47 0.61 2.13e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg20151795 chr6:28129481 ZNF389 -0.38 -5.09 -0.3 6.78e-7 Depression; CESC cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg03433033 chr1:76189801 ACADM 0.71 9.78 0.52 1.68e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9916302 0.861 rs12150493 chr17:37586154 T/C cg15445000 chr17:37608096 MED1 0.41 6.74 0.38 9.67e-11 Glomerular filtration rate (creatinine); CESC cis rs7184046 0.797 rs13737 chr15:75932129 G/T cg20655648 chr15:75932815 IMP3 0.53 6.55 0.37 3.06e-10 Height; CESC cis rs901683 1.000 rs17157880 chr10:46014488 A/G cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs7264396 0.790 rs6060519 chr20:34217383 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.93 -0.59 1.51e-26 Total cholesterol levels; CESC cis rs11719291 0.833 rs11709246 chr3:48859498 G/A cg00383909 chr3:49044727 WDR6 0.92 6.66 0.38 1.62e-10 Cognitive function; CESC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC trans rs1814175 0.669 rs10839315 chr11:49654406 G/A cg03929089 chr4:120376271 NA -0.74 -9.52 -0.5 1.12e-18 Height; CESC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs698833 0.886 rs4953087 chr2:44561627 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.57 7.14 0.4 8.89e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg04772025 chr11:68637568 NA 0.55 6.49 0.37 4.17e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg11644478 chr21:40555479 PSMG1 -1.03 -17.64 -0.73 1.33e-46 Cognitive function; CESC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg18337363 chr3:52569053 NT5DC2 0.3 5.09 0.3 6.83e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27488751 chr21:43916608 RSPH1 0.56 6.02 0.35 5.75e-9 Gut microbiome composition (summer); CESC trans rs3780486 0.846 rs10971420 chr9:33125000 T/C cg04842962 chr6:43655489 MRPS18A 1.01 19.48 0.77 4.55e-53 IgG glycosylation; CESC cis rs8062405 0.690 rs762634 chr16:28603335 T/C cg07382826 chr16:28625726 SULT1A1 0.4 6.48 0.37 4.38e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2629540 0.847 rs34032724 chr10:126408869 T/G cg08799069 chr10:126477246 METTL10 0.59 7.49 0.42 1.02e-12 Cocaine dependence; CESC cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.89 0.34 1.15e-8 Hip circumference adjusted for BMI; CESC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg13628971 chr7:2884303 GNA12 0.58 7.46 0.42 1.26e-12 Height; CESC cis rs7520050 0.933 rs6680211 chr1:46315007 C/G cg24296786 chr1:45957014 TESK2 0.42 5.42 0.32 1.33e-7 Red blood cell count;Reticulocyte count; CESC cis rs7216064 0.906 rs7223643 chr17:65830282 A/G cg07042672 chr17:66097459 LOC651250 -0.53 -5.91 -0.34 1.04e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25320668 chr1:205196970 TMCC2 0.59 6.92 0.39 3.38e-11 Gut microbiome composition (summer); CESC cis rs796364 0.806 rs12616905 chr2:201007764 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -6.48 -0.37 4.47e-10 Schizophrenia; CESC cis rs72829446 0.530 rs4796421 chr17:7379650 C/T cg02795151 chr17:7402630 POLR2A 0.62 6.47 0.37 4.72e-10 Androgen levels; CESC cis rs9660992 0.736 rs72745207 chr1:205251991 C/G cg00857998 chr1:205179979 DSTYK 0.47 5.36 0.31 1.83e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs4144027 0.904 rs10438242 chr14:104345075 C/T cg08213375 chr14:104286397 PPP1R13B -0.29 -5.07 -0.3 7.56e-7 Blood metabolite levels; CESC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg07092213 chr7:1199455 ZFAND2A -0.43 -5.06 -0.3 7.75e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10751667 0.621 rs7394681 chr11:952111 C/T cg06064525 chr11:970664 AP2A2 -0.48 -9.51 -0.5 1.2e-18 Alzheimer's disease (late onset); CESC cis rs7786808 0.712 rs2335167 chr7:158213948 A/C cg09998033 chr7:158218633 PTPRN2 -0.42 -6.12 -0.35 3.31e-9 Obesity-related traits; CESC cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg12463550 chr7:65579703 CRCP 0.67 5.38 0.31 1.67e-7 Diabetic kidney disease; CESC cis rs2243480 1.000 rs4718334 chr7:65789454 G/A cg12463550 chr7:65579703 CRCP -0.66 -5.3 -0.31 2.46e-7 Diabetic kidney disease; CESC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.36 5.83 0.34 1.6e-8 Personality dimensions; CESC cis rs1372520 0.684 rs2737030 chr4:90710099 C/T cg15133208 chr4:90757351 SNCA -0.4 -5.3 -0.31 2.43e-7 Neuroticism; CESC cis rs7824557 0.767 rs11775635 chr8:11164865 G/A cg21775007 chr8:11205619 TDH 0.5 7.27 0.41 4e-12 Retinal vascular caliber; CESC cis rs9929218 0.817 rs3114405 chr16:68722377 G/A cg02972257 chr16:68554789 NA 0.6 6.53 0.37 3.42e-10 Colorectal cancer; CESC cis rs113835537 0.529 rs11227502 chr11:66274148 T/G cg24851651 chr11:66362959 CCS 0.43 5.41 0.32 1.4e-7 Airway imaging phenotypes; CESC cis rs11711311 0.955 rs34458493 chr3:113396473 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.53 6.58 0.37 2.54e-10 IgG glycosylation; CESC cis rs2072732 0.861 rs6679678 chr1:2950594 T/C cg03976712 chr1:2946727 NA 0.33 5.45 0.32 1.17e-7 Plateletcrit; CESC cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg17191109 chr10:126851326 NA -0.54 -9.16 -0.49 1.43e-17 Menarche (age at onset); CESC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg06873352 chr17:61820015 STRADA 0.72 12.3 0.6 8.09e-28 Prudent dietary pattern; CESC trans rs629535 0.814 rs604254 chr8:70059164 A/G cg21567404 chr3:27674614 NA 0.89 10.42 0.54 1.56e-21 Dupuytren's disease; CESC cis rs78456975 1.000 rs10205916 chr2:1558451 A/T cg26248373 chr2:1572462 NA 0.59 5.57 0.32 6.27e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs16917546 0.967 rs10995239 chr10:64388365 A/G cg03961010 chr10:64397487 ZNF365 -0.39 -6.22 -0.36 1.92e-9 Basal cell carcinoma; CESC cis rs1707322 0.752 rs12062535 chr1:46222880 G/A cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7923609 0.869 rs10733792 chr10:65232539 A/G cg01631684 chr10:65280961 REEP3 -0.44 -5.44 -0.32 1.2e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs10032549 0.535 rs1511817 chr4:77386678 A/G cg20311846 chr4:77356250 SHROOM3 0.29 5.48 0.32 1e-7 Glomerular filtration rate; CESC cis rs7301826 0.932 rs1007246 chr12:131280130 T/A cg11011512 chr12:131303247 STX2 0.41 5.25 0.31 3.1e-7 Plasma plasminogen activator levels; CESC trans rs7760535 0.656 rs7766190 chr6:111905066 A/G cg00852768 chr6:163834924 QKI -0.4 -6.07 -0.35 4.35e-9 Metabolic traits; CESC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.04 0.3 8.76e-7 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06130371 chr15:65578830 PARP16 0.55 6.08 0.35 4.22e-9 Gut microbiome composition (summer); CESC cis rs9303280 0.806 rs9907088 chr17:38035116 G/A cg19468946 chr17:37922297 IKZF3 -0.41 -5.42 -0.32 1.31e-7 Self-reported allergy; CESC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg03647317 chr4:187891568 NA -0.38 -5.7 -0.33 3.21e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg02018176 chr4:1364513 KIAA1530 0.42 5.61 0.33 5.08e-8 Longevity; CESC cis rs7772486 0.846 rs1474871 chr6:146406294 G/A cg05347473 chr6:146136440 FBXO30 0.5 6.76 0.38 8.77e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs8067354 0.574 rs2526358 chr17:57942585 A/G cg02344993 chr17:57696989 CLTC 0.53 5.45 0.32 1.14e-7 Hemoglobin concentration; CESC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg23982607 chr1:1823379 GNB1 -0.8 -13.13 -0.63 1.14e-30 Body mass index; CESC cis rs8038465 0.662 rs7497012 chr15:73968719 G/A cg15420318 chr15:73925796 NPTN 0.53 7.85 0.43 1.05e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg11161846 chr1:160990452 F11R -0.44 -6.06 -0.35 4.53e-9 Granulocyte percentage of myeloid white cells; CESC cis rs2242116 0.734 rs4683294 chr3:46979013 C/G cg02527881 chr3:46936655 PTH1R 0.4 5.82 0.34 1.69e-8 Birth weight; CESC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg17143192 chr8:8559678 CLDN23 0.71 8.34 0.46 4.02e-15 Obesity-related traits; CESC cis rs116095464 0.558 rs12173244 chr5:269524 G/A cg20965017 chr5:231967 SDHA -0.48 -5.44 -0.32 1.22e-7 Breast cancer; CESC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg24829409 chr8:58192753 C8orf71 -0.75 -9.9 -0.52 7.27e-20 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg27170947 chr2:26402098 FAM59B 0.87 9.85 0.52 1.01e-19 Gut microbiome composition (summer); CESC cis rs72781680 0.752 rs72796130 chr2:23919740 T/C cg20701182 chr2:24300061 SF3B14 0.79 6.88 0.39 4.25e-11 Lymphocyte counts; CESC cis rs56104184 0.723 rs1058483 chr19:49407660 G/A cg15549821 chr19:49342101 PLEKHA4 -0.57 -5.73 -0.33 2.67e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg17366294 chr4:99064904 C4orf37 -0.61 -8.72 -0.47 3.14e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.11e-8 Alzheimer's disease; CESC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg26338869 chr17:61819248 STRADA 0.67 8.79 0.48 1.9e-16 Prudent dietary pattern; CESC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg22920501 chr2:26401640 FAM59B 0.92 10.56 0.54 5.52e-22 Gut microbiome composition (summer); CESC cis rs708547 0.647 rs1718878 chr4:57876955 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.47 6.61 0.38 2.11e-10 Response to bleomycin (chromatid breaks); CESC trans rs61931739 0.500 rs7296061 chr12:34435009 A/G cg26384229 chr12:38710491 ALG10B -0.67 -9.97 -0.52 4.27e-20 Morning vs. evening chronotype; CESC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg27535305 chr1:53392650 SCP2 0.32 5.13 0.3 5.71e-7 Monocyte count; CESC cis rs477692 0.673 rs579952 chr10:131356084 A/T cg24747557 chr10:131355152 MGMT 0.39 5.37 0.31 1.72e-7 Response to temozolomide; CESC cis rs6582630 0.502 rs11504451 chr12:38425294 G/A cg26384229 chr12:38710491 ALG10B 0.68 10.04 0.52 2.6e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs2806561 0.808 rs2294518 chr1:23372771 T/C cg12483005 chr1:23474871 LUZP1 -0.34 -5.3 -0.31 2.42e-7 Height; CESC cis rs13064447 0.753 rs9811396 chr3:12747915 A/G cg23032965 chr3:12705835 RAF1 0.41 5.15 0.3 5.14e-7 Major depression and alcohol dependence; CESC trans rs66573146 0.831 rs73088564 chr4:6984553 G/C cg07817883 chr1:32538562 TMEM39B 1.21 7.99 0.44 4.16e-14 Granulocyte percentage of myeloid white cells; CESC cis rs2425143 1.000 rs74785978 chr20:34373234 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.12 -0.4 1.01e-11 Blood protein levels; CESC cis rs4523957 0.651 rs9906705 chr17:2063714 T/G cg16513277 chr17:2031491 SMG6 -0.72 -10.2 -0.53 8.12e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1775715 0.737 rs2778650 chr10:32106851 A/G cg18675610 chr10:32216311 ARHGAP12 0.34 5.27 0.31 2.85e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg18402987 chr7:1209562 NA 0.73 7.36 0.41 2.28e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.52 5.7 0.33 3.12e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg08888203 chr3:10149979 C3orf24 0.45 5.71 0.33 3.04e-8 Alzheimer's disease; CESC cis rs921968 0.541 rs593888 chr2:219427597 A/G cg02176678 chr2:219576539 TTLL4 0.49 8.92 0.48 7.68e-17 Mean corpuscular hemoglobin concentration; CESC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.58 0.37 2.56e-10 Prudent dietary pattern; CESC cis rs684232 0.583 rs10521106 chr17:510707 C/T cg12384639 chr17:618140 VPS53 0.4 5.1 0.3 6.44e-7 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00985205 chr4:71570491 RUFY3 0.55 6.43 0.37 5.96e-10 Gut microbiome composition (summer); CESC cis rs2708240 0.666 rs2538962 chr7:147600604 C/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.18e-8 QT interval (drug interaction); CESC cis rs2191566 0.691 rs59086054 chr19:44549096 C/A cg20607764 chr19:44506953 ZNF230 -0.43 -5.52 -0.32 8.25e-8 Acute lymphoblastic leukemia (childhood); CESC trans rs12505749 1.000 rs17756240 chr4:57355192 G/C cg09583921 chr3:87101925 NA 0.97 6.07 0.35 4.48e-9 Airflow obstruction; CESC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.65 5.71 0.33 3.07e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6963495 0.818 rs73190202 chr7:105166510 A/G cg19920283 chr7:105172520 RINT1 0.7 6.68 0.38 1.39e-10 Bipolar disorder (body mass index interaction); CESC cis rs2439831 0.850 rs12441127 chr15:44021175 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.76 0.38 8.96e-11 Lung cancer in ever smokers; CESC cis rs1153858 1.000 rs9788780 chr15:45685487 T/A cg14582100 chr15:45693742 SPATA5L1 0.41 5.77 0.33 2.17e-8 Homoarginine levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg02772733 chr9:139703466 C9orf86;LOC100131193 -0.47 -6.68 -0.38 1.36e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7267979 1.000 rs2258879 chr20:25279213 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg09263875 chr16:632152 PIGQ 0.68 11.77 0.59 5.12e-26 Height; CESC cis rs412050 1.000 rs239916 chr22:22316272 G/A cg17089214 chr22:22089827 YPEL1 0.65 6.03 0.35 5.37e-9 Attention deficit hyperactivity disorder; CESC cis rs2235642 0.928 rs56289115 chr16:1608934 A/G cg09080909 chr16:1797204 MAPK8IP3 -0.37 -5.21 -0.3 3.79e-7 Coronary artery disease; CESC cis rs6500602 0.893 rs4786490 chr16:4491190 C/T cg08645402 chr16:4508243 NA -0.44 -6.63 -0.38 1.86e-10 Schizophrenia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08318582 chr11:109920663 NA -0.44 -6.09 -0.35 3.89e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00761755 chr17:1531579 SLC43A2 0.46 6.13 0.35 3.2e-9 Systemic lupus erythematosus; CESC trans rs1941023 0.672 rs2155710 chr11:60269240 C/T cg05115468 chr11:62623202 SNORD27;SLC3A2;SNORD26;SNORD28;SNORD25;SNHG1 0.55 6.6 0.38 2.29e-10 Congenital heart disease (maternal effect); CESC cis rs1107366 0.750 rs9825571 chr3:125900161 A/G cg20988073 chr3:125900093 ALDH1L1 -0.36 -5.12 -0.3 5.96e-7 Metabolite levels; CESC cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg07697082 chr8:82753677 SNX16 0.39 6.08 0.35 4.26e-9 Diastolic blood pressure; CESC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg11890956 chr21:40555474 PSMG1 -0.65 -9.1 -0.49 2.28e-17 Menarche (age at onset); CESC cis rs9291683 0.530 rs17246501 chr4:9985710 A/C cg00071950 chr4:10020882 SLC2A9 0.77 13.84 0.65 3.79e-33 Bone mineral density; CESC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg04511125 chr2:88470314 THNSL2 0.7 6.79 0.38 7.52e-11 Plasma clusterin levels; CESC cis rs287982 0.932 rs11887231 chr2:9967116 C/A cg10881225 chr2:9984929 TAF1B 0.4 5.16 0.3 4.94e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs116095464 0.510 rs10057501 chr5:239545 T/C cg10591111 chr5:226296 SDHA -0.5 -6.13 -0.35 3.17e-9 Breast cancer; CESC cis rs13095912 0.785 rs6791954 chr3:185335709 C/T cg11274856 chr3:185301563 NA -0.37 -5.65 -0.33 4.05e-8 Systolic blood pressure; CESC cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.21e-14 Blood protein levels; CESC cis rs7834588 0.523 rs4623409 chr8:63829131 A/G cg20602954 chr8:63776762 NKAIN3 0.3 5.04 0.3 8.69e-7 Response to Vitamin E supplementation; CESC cis rs8062405 0.964 rs7187333 chr16:28865916 G/A cg05966235 chr16:28915196 ATP2A1 0.34 5.03 0.3 9.05e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg26354017 chr1:205819088 PM20D1 0.8 11.85 0.59 2.77e-26 Menarche (age at onset); CESC cis rs761746 0.804 rs5749304 chr22:31967775 A/G cg25791279 chr22:32026902 PISD -0.55 -6.29 -0.36 1.33e-9 Intelligence; CESC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg15320075 chr8:145703422 NA -0.71 -10.2 -0.53 7.78e-21 Age at first birth; CESC cis rs10242455 0.702 rs76840929 chr7:98945858 T/C cg25640893 chr7:99214727 ZNF498 0.85 5.71 0.33 3.01e-8 Blood metabolite levels; CESC cis rs6991838 0.584 rs4737748 chr8:66525865 C/T cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg27170947 chr2:26402098 FAM59B -0.59 -7.07 -0.4 1.36e-11 Gut microbiome composition (summer); CESC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg13298116 chr11:62369859 EML3;MTA2 0.65 9.39 0.5 2.97e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25367318 chr6:138725211 HEBP2 0.48 6.32 0.36 1.1e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.791 rs34790496 chr4:98930516 C/T cg17366294 chr4:99064904 C4orf37 0.58 8.02 0.44 3.43e-14 Colonoscopy-negative controls vs population controls; CESC cis rs11252926 0.574 rs7068976 chr10:453112 A/G cg16386425 chr10:429943 DIP2C -0.55 -7.02 -0.4 1.89e-11 Psychosis in Alzheimer's disease; CESC cis rs116095464 0.558 rs34629844 chr5:200829 A/G cg22496380 chr5:211416 CCDC127 -0.95 -10.43 -0.54 1.43e-21 Breast cancer; CESC cis rs7737355 0.812 rs7729787 chr5:131066577 A/C cg06307176 chr5:131281290 NA 0.38 5.15 0.3 5.19e-7 Life satisfaction; CESC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.54 0.37 3.16e-10 Prudent dietary pattern; CESC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg16278512 chr7:12443529 VWDE -0.52 -5.71 -0.33 3.08e-8 Coronary artery disease; CESC cis rs2235642 0.928 rs1057610 chr16:1605537 T/C cg08296037 chr16:1584118 IFT140;TMEM204 -0.31 -5.19 -0.3 4.13e-7 Coronary artery disease; CESC cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg01475377 chr6:109611718 NA -0.48 -7.91 -0.44 7.09e-14 Reticulocyte fraction of red cells; CESC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg24060327 chr5:131705240 SLC22A5 0.76 10.65 0.55 2.72e-22 Breast cancer; CESC cis rs1395 0.744 rs4665962 chr2:27515105 A/G cg22903471 chr2:27725779 GCKR -0.5 -6.08 -0.35 4.12e-9 Blood metabolite levels; CESC cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg08917208 chr2:24149416 ATAD2B 0.6 5.66 0.33 3.99e-8 Lymphocyte counts; CESC cis rs524023 0.914 rs11607663 chr11:64368670 G/C cg07220939 chr11:64358617 SLC22A12 -0.36 -5.36 -0.31 1.82e-7 Urate levels in obese individuals; CESC cis rs13102973 0.965 rs13108037 chr4:135885643 A/G cg14419869 chr4:135874104 NA -0.33 -5.17 -0.3 4.66e-7 Subjective well-being; CESC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg08888203 chr3:10149979 C3orf24 0.45 5.79 0.34 1.94e-8 Alzheimer's disease; CESC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg23172400 chr8:95962367 TP53INP1 -0.45 -9.25 -0.49 8.02e-18 Type 2 diabetes; CESC cis rs17666538 0.710 rs12716640 chr8:645376 A/C cg23958373 chr8:599963 NA 0.8 6.97 0.39 2.54e-11 IgG glycosylation; CESC cis rs4072980 0.545 rs16824518 chr1:38415315 A/C cg12658694 chr1:38397304 INPP5B -0.67 -8.89 -0.48 9.96e-17 Coronary artery disease; CESC cis rs8067545 0.611 rs2013443 chr17:20023109 G/C cg13482628 chr17:19912719 NA 0.43 5.72 0.33 2.88e-8 Schizophrenia; CESC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg25934064 chr3:52569026 NT5DC2 0.27 5.38 0.31 1.61e-7 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.15.1525362R chr15:89706202 ABHD2 -0.58 -6.64 -0.38 1.74e-10 Gut microbiome composition (summer); CESC cis rs919433 0.783 rs788014 chr2:198228997 G/A cg03934865 chr2:198174659 NA 0.43 6.18 0.35 2.41e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7772486 0.686 rs857875 chr6:145980033 T/G cg23711669 chr6:146136114 FBXO30 -0.91 -13.7 -0.64 1.16e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs6693567 0.565 rs834225 chr1:150300727 T/C cg09579323 chr1:150459698 TARS2 0.48 6.11 0.35 3.63e-9 Migraine; CESC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg11663144 chr21:46675770 NA -0.62 -9.82 -0.52 1.27e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08524698 chr22:21213167 SNAP29;PI4KA 0.52 6.3 0.36 1.22e-9 Gut microbiome composition (summer); CESC cis rs2832191 0.791 rs2251517 chr21:30531951 T/G cg08807101 chr21:30365312 RNF160 0.76 10.63 0.55 3.33e-22 Dental caries; CESC cis rs6812193 0.518 rs28864163 chr4:77195106 G/C cg20311846 chr4:77356250 SHROOM3 0.3 5.2 0.3 4.06e-7 Parkinson's disease; CESC cis rs8005677 0.962 rs10130756 chr14:23396600 C/G cg01529538 chr14:23388837 RBM23 0.51 6.84 0.39 5.51e-11 Cognitive ability (multi-trait analysis); CESC cis rs7917772 0.636 rs1475644 chr10:104491164 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.46 5.4 0.32 1.45e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs4975709 0.801 rs3797063 chr5:1881549 A/T cg15595755 chr5:1867978 NA 0.44 6.77 0.38 8.35e-11 Cardiovascular disease risk factors; CESC cis rs117623576 1.000 rs117623576 chr10:32387808 C/T cg03047570 chr10:32398778 NA -0.8 -7.21 -0.4 5.83e-12 Anti-saccade response; CESC cis rs2832191 1.000 rs2832190 chr21:30488226 G/A cg08807101 chr21:30365312 RNF160 -0.67 -9.05 -0.49 3.2e-17 Dental caries; CESC cis rs60311166 1.000 rs7643568 chr3:52578474 A/G cg13174197 chr3:52720522 GNL3;PBRM1 0.7 5.13 0.3 5.71e-7 CTACK levels; CESC trans rs11039798 1.000 rs7942042 chr11:48520270 A/G cg15704280 chr7:45808275 SEPT13 0.69 6.39 0.37 7.41e-10 Axial length; CESC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg18032046 chr6:28092343 ZSCAN16 -0.61 -6.96 -0.39 2.6e-11 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26313349 chr1:145589328 NUDT17 0.64 7.67 0.43 3.33e-13 Gut microbiome composition (summer); CESC cis rs733175 0.904 rs3775944 chr4:10019974 G/T cg00071950 chr4:10020882 SLC2A9 0.56 6.2 0.36 2.16e-9 Psychosis and Alzheimer's disease; CESC cis rs143699489 1 rs143699489 chr3:140927121 A/G cg16418163 chr3:140950828 ACPL2 0.65 6.52 0.37 3.5e-10 White blood cell count;Granulocyte count;Sum neutrophil eosinophil counts; CESC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg11663144 chr21:46675770 NA -0.56 -8.66 -0.47 4.69e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4851551 1.000 rs4851552 chr2:102802333 G/A cg09363443 chr2:102758946 NA 0.61 5.11 0.3 6.23e-7 Blood protein levels; CESC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg11766577 chr21:47581405 C21orf56 0.49 6.83 0.39 5.68e-11 Testicular germ cell tumor; CESC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg17178900 chr1:205818956 PM20D1 0.81 12.96 0.62 4.5e-30 Menarche (age at onset); CESC cis rs250677 0.687 rs250666 chr5:148454622 A/G cg18129178 chr5:148520854 ABLIM3 -0.51 -5.91 -0.34 1.05e-8 Breast cancer; CESC cis rs858239 0.601 rs1034963 chr7:23148473 T/C cg23682824 chr7:23144976 KLHL7 0.55 7.81 0.43 1.35e-13 Cerebrospinal fluid biomarker levels; CESC cis rs7666738 0.830 rs7672127 chr4:98938477 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.29 0.45 5.6e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2991971 0.782 rs10789463 chr1:45927848 C/A cg24296786 chr1:45957014 TESK2 -0.61 -8.88 -0.48 1.06e-16 High light scatter reticulocyte count; CESC cis rs3767633 0.800 rs6685369 chr1:161754834 T/C cg09175582 chr1:161736000 ATF6 0.8 6.57 0.37 2.59e-10 IgG glycosylation; CESC cis rs12476592 0.602 rs262488 chr2:63882179 C/T cg17519650 chr2:63277830 OTX1 -0.45 -5.06 -0.3 8.03e-7 Childhood ear infection; CESC cis rs8062405 1.000 rs80275162 chr16:28863517 T/A cg08761264 chr16:28874980 SH2B1 -0.45 -5.66 -0.33 3.9e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9287719 0.901 rs10210859 chr2:10733929 C/T cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.35e-8 Prostate cancer; CESC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg18099408 chr3:52552593 STAB1 -0.31 -5.16 -0.3 4.9e-7 Bipolar disorder; CESC cis rs9649213 0.614 rs2240348 chr7:97984077 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.45 -6.17 -0.35 2.58e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs561341 1.000 rs1557731 chr17:30321567 T/G cg12193833 chr17:30244370 NA -0.59 -5.92 -0.34 9.93e-9 Hip circumference adjusted for BMI; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg19279529 chr19:35760554 USF2 -0.46 -6.21 -0.36 2.03e-9 Vertical cup-disc ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21542780 chr2:234763377 HJURP 0.55 6.07 0.35 4.51e-9 Gut microbiome composition (summer); CESC cis rs2932538 0.922 rs7527076 chr1:113150481 G/A cg22162597 chr1:113214053 CAPZA1 0.59 7.46 0.42 1.28e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.07 20.05 0.78 4.94e-55 Prudent dietary pattern; CESC cis rs1008375 0.932 rs10009933 chr4:17670107 A/C cg02297831 chr4:17616191 MED28 0.5 5.94 0.34 8.77e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9300255 0.602 rs11057192 chr12:123693420 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.83 0.48 1.41e-16 Neutrophil percentage of white cells; CESC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs7772486 0.875 rs1330939 chr6:146308518 T/A cg05347473 chr6:146136440 FBXO30 0.53 7.12 0.4 1.02e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6500602 0.679 rs736685 chr16:4508606 T/C cg08645402 chr16:4508243 NA 0.56 8.82 0.48 1.53e-16 Schizophrenia; CESC trans rs17764205 0.777 rs112570652 chr19:3255789 G/A cg12868887 chr11:70244470 CTTN 0.78 6.08 0.35 4.14e-9 Bipolar disorder and schizophrenia; CESC trans rs7009110 0.527 rs7822342 chr8:81246699 C/T cg21552319 chr6:24356996 DCDC2;KAAG1 -0.36 -6.09 -0.35 4e-9 Asthma and hay fever; CESC cis rs8028313 0.504 rs2899730 chr15:68172520 G/T cg26545918 chr15:68124484 LBXCOR1 -0.31 -5.21 -0.3 3.77e-7 Obesity; CESC cis rs62344088 0.590 rs62346174 chr5:296308 C/A cg22857025 chr5:266934 NA -1.25 -7.24 -0.41 4.88e-12 Asthma (childhood onset); CESC cis rs11718455 0.960 rs4682713 chr3:44013191 G/C cg08738300 chr3:44038990 NA 0.47 6.0 0.35 6.51e-9 Coronary artery disease; CESC trans rs7246657 0.943 rs12709813 chr19:37844983 G/A cg24637308 chr11:6592297 DNHD1 0.53 6.17 0.35 2.55e-9 Coronary artery calcification; CESC cis rs7336332 0.598 rs1885989 chr13:28010117 G/A cg22138327 chr13:27999177 GTF3A 0.63 5.88 0.34 1.21e-8 Weight; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03321319 chr22:22222323 MAPK1 0.57 6.6 0.38 2.21e-10 Gut microbiome composition (summer); CESC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg04756594 chr16:24857601 SLC5A11 0.45 5.21 0.3 3.83e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs959260 1.000 rs7226070 chr17:73372811 T/C cg20590849 chr17:73267439 MIF4GD -0.55 -6.44 -0.37 5.48e-10 Systemic lupus erythematosus; CESC cis rs3020736 0.500 rs5996111 chr22:42493902 C/T cg04733989 chr22:42467013 NAGA -0.82 -12.04 -0.59 6.5e-27 Autism spectrum disorder or schizophrenia; CESC cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg15052019 chr19:19431593 KIAA0892;SF4 -0.43 -5.46 -0.32 1.11e-7 Tonsillectomy; CESC cis rs2481665 0.680 rs2481671 chr1:62611666 A/C cg18591186 chr1:62594603 INADL -0.42 -5.18 -0.3 4.3e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7264396 0.635 rs2064724 chr20:34522520 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.58 6.99 0.39 2.22e-11 Total cholesterol levels; CESC cis rs3859192 0.599 rs2227319 chr17:38170845 G/A cg17467752 chr17:38218738 THRA -0.45 -5.96 -0.34 7.93e-9 White blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.7.1264585R chr7:55212640 EGFR -0.63 -7.27 -0.41 4.16e-12 Gut microbiome composition (summer); CESC cis rs6141600 0.760 rs2746103 chr20:34703934 T/G cg23207816 chr20:34252616 CPNE1;RBM12 0.4 5.36 0.31 1.81e-7 Height;Hip circumference; CESC cis rs2243480 1.000 rs2961102 chr7:65424658 A/G cg12463550 chr7:65579703 CRCP 0.69 5.49 0.32 9.63e-8 Diabetic kidney disease; CESC cis rs829883 0.738 rs249846 chr12:98868739 T/C cg25150519 chr12:98850993 NA 0.85 14.58 0.67 9.66e-36 Colorectal adenoma (advanced); CESC cis rs9911578 0.967 rs6503883 chr17:56917543 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis); CESC cis rs10883723 0.810 rs10748824 chr10:104274466 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.58 0.42 5.73e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs10870270 0.956 rs7894 chr10:133769482 G/C cg08754478 chr10:133766260 PPP2R2D -0.59 -7.52 -0.42 8.44e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11387077 chr7:30544503 GGCT -0.46 -5.99 -0.35 6.71e-9 Ulcerative colitis; CESC cis rs7827545 0.620 rs6578009 chr8:135522989 T/C cg17885191 chr8:135476712 NA -0.56 -7.53 -0.42 7.97e-13 Hypertension (SNP x SNP interaction); CESC cis rs7193541 0.640 rs4072222 chr16:74706736 A/C cg05580060 chr16:74700937 RFWD3 -0.44 -5.73 -0.33 2.67e-8 Multiple myeloma; CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg18404041 chr3:52824283 ITIH1 -0.32 -5.8 -0.34 1.84e-8 Bipolar disorder; CESC cis rs193541 0.632 rs1363200 chr5:122163802 G/T cg19412675 chr5:122181750 SNX24 0.45 5.15 0.3 4.98e-7 Glucose homeostasis traits; CESC cis rs858239 0.601 rs6948469 chr7:23174766 G/T cg23682824 chr7:23144976 KLHL7 0.53 7.35 0.41 2.41e-12 Cerebrospinal fluid biomarker levels; CESC cis rs2997447 0.653 rs56134135 chr1:26440718 A/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs7208859 0.673 rs3764421 chr17:29167653 A/C cg19761014 chr17:28927070 LRRC37B2 0.72 5.68 0.33 3.48e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7605827 0.866 rs2160696 chr2:15518983 A/T cg19274914 chr2:15703543 NA 0.36 6.45 0.37 5.37e-10 Educational attainment (years of education); CESC cis rs6952808 0.931 rs12537430 chr7:1868761 A/G cg04267008 chr7:1944627 MAD1L1 0.55 6.72 0.38 1.11e-10 Bipolar disorder and schizophrenia; CESC cis rs5753618 0.529 rs5749298 chr22:31941032 C/T cg00478049 chr22:31556069 RNF185 -0.48 -5.81 -0.34 1.79e-8 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02908720 chr7:127292155 SND1 0.59 6.8 0.39 7.02e-11 Gut microbiome composition (summer); CESC cis rs2011503 1.000 rs77427798 chr19:19652982 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.12 0.3 5.87e-7 Bipolar disorder; CESC cis rs854765 0.647 rs854790 chr17:18028318 C/G cg04398451 chr17:18023971 MYO15A -0.78 -10.97 -0.56 2.39e-23 Total body bone mineral density; CESC cis rs7267979 0.932 rs1985737 chr20:25591468 T/A cg24626310 chr20:25276739 ABHD12;PYGB 0.73 12.75 0.62 2.34e-29 Liver enzyme levels (alkaline phosphatase); CESC cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg19626725 chr5:178986131 RUFY1 0.39 6.37 0.36 8.51e-10 Lung cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24043307 chr12:51157954 ATF1 0.47 6.34 0.36 1e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs5758343 1 rs5758343 chr22:41816652 A/T cg06481639 chr22:41940642 POLR3H 0.64 6.41 0.37 6.77e-10 Allergic disease (asthma, hay fever or eczema); CESC cis rs10883723 0.669 rs2001595 chr10:104395085 C/T cg22532475 chr10:104410764 TRIM8 -0.45 -6.89 -0.39 4.1e-11 Allergic disease (asthma, hay fever or eczema); CESC trans rs60380162 0.963 rs4259617 chr1:87725048 G/A cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.03 -0.35 5.48e-9 Loneliness (linear analysis); CESC cis rs939658 0.805 rs34222382 chr15:79440748 C/T cg17916960 chr15:79447300 NA -0.37 -6.12 -0.35 3.31e-9 Refractive error; CESC cis rs6540559 0.546 rs634601 chr1:210421594 C/T cg22029157 chr1:209979665 IRF6 0.48 5.89 0.34 1.2e-8 Cleft lip with or without cleft palate; CESC cis rs34779708 0.897 rs11010131 chr10:35513316 A/C cg03585969 chr10:35415529 CREM 0.75 9.3 0.5 5.36e-18 Inflammatory bowel disease;Crohn's disease; CESC trans rs66573146 0.572 rs66611116 chr4:6953270 A/G cg07817883 chr1:32538562 TMEM39B 1.14 7.95 0.44 5.27e-14 Granulocyte percentage of myeloid white cells; CESC cis rs2353275 0.655 rs2140669 chr10:88278368 A/G cg07322936 chr10:88137208 NA 0.95 5.86 0.34 1.4e-8 Asthma (childhood onset);Asthma; CESC cis rs10463316 0.823 rs7700340 chr5:150776320 C/T cg03212797 chr5:150827313 SLC36A1 -0.45 -5.9 -0.34 1.12e-8 Metabolite levels (Pyroglutamine); CESC cis rs4835473 0.932 rs13147386 chr4:144657739 C/T cg25736465 chr4:144833511 NA 0.33 5.16 0.3 4.91e-7 Immature fraction of reticulocytes; CESC cis rs80282103 0.618 rs2279256 chr10:1132852 G/A cg08668510 chr10:1095578 IDI1 0.71 5.54 0.32 7.34e-8 Glomerular filtration rate (creatinine); CESC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Depression; CESC cis rs2072732 0.861 rs72629497 chr1:2954123 T/C cg03976712 chr1:2946727 NA 0.33 5.53 0.32 7.83e-8 Plateletcrit; CESC cis rs9303401 1.000 rs1390006 chr17:56890663 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.72 -9.36 -0.5 3.51e-18 Cognitive test performance; CESC cis rs2204008 0.729 rs2892365 chr12:38446760 G/C cg13010199 chr12:38710504 ALG10B -0.42 -5.52 -0.32 8.07e-8 Bladder cancer; CESC cis rs67072384 1.000 rs7124056 chr11:72444747 C/T cg04827223 chr11:72435913 ARAP1 0.66 7.59 0.42 5.37e-13 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs6137287 0.722 rs1007226 chr20:21103987 A/G cg13880779 chr20:21376337 NKX2-4 0.33 5.14 0.3 5.26e-7 Height; CESC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg00129232 chr17:37814104 STARD3 0.59 7.82 0.43 1.22e-13 Glomerular filtration rate (creatinine); CESC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.04 -0.3 8.58e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg02297831 chr4:17616191 MED28 0.53 6.73 0.38 1.04e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg00166722 chr3:10149974 C3orf24 0.48 6.15 0.35 2.89e-9 Alzheimer's disease; CESC cis rs9837602 1.000 rs6802422 chr3:99778655 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -6.58 -0.37 2.47e-10 Breast cancer; CESC cis rs35110281 0.666 rs9977076 chr21:45085829 G/A cg21573476 chr21:45109991 RRP1B -0.59 -8.63 -0.47 5.87e-16 Mean corpuscular volume; CESC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.31 -0.31 2.36e-7 Total body bone mineral density; CESC cis rs1270639 0.778 rs1796272 chr7:157437832 C/T cg13357408 chr7:157437802 PTPRN2 -0.58 -6.88 -0.39 4.27e-11 Colorectal cancer; CESC cis rs2425143 0.547 rs6141583 chr20:34572834 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -5.8 -0.34 1.88e-8 Blood protein levels; CESC cis rs113835537 0.529 rs7950790 chr11:66258053 G/A cg22134325 chr11:66188745 NPAS4 0.34 5.27 0.31 2.82e-7 Airway imaging phenotypes; CESC cis rs616402 0.527 rs11584327 chr1:10578791 T/C cg17425144 chr1:10567563 PEX14 0.38 6.03 0.35 5.6e-9 Breast size; CESC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg10494973 chr17:80897199 TBCD 0.51 5.89 0.34 1.14e-8 Breast cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27376817 chr7:75931888 HSPB1 0.45 6.16 0.35 2.62e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2439831 0.867 rs16957632 chr15:43642897 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.85 12.05 0.59 6.08e-27 Lung cancer in ever smokers; CESC cis rs4835473 0.897 rs7662736 chr4:144879189 C/T cg25736465 chr4:144833511 NA 0.39 5.89 0.34 1.16e-8 Immature fraction of reticulocytes; CESC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg08888203 chr3:10149979 C3orf24 0.49 6.12 0.35 3.29e-9 Alzheimer's disease; CESC cis rs731174 1.000 rs731174 chr1:38196841 C/T cg12339802 chr1:38156545 C1orf109 0.48 5.6 0.33 5.37e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg09365446 chr1:150670422 GOLPH3L 0.4 5.24 0.31 3.36e-7 Melanoma; CESC cis rs6690583 1.000 rs10443172 chr1:85485768 T/C cg11262906 chr1:85462892 MCOLN2 -0.52 -5.85 -0.34 1.46e-8 Serum sulfate level; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22516162 chr12:133363304 GOLGA3 0.46 6.0 0.35 6.52e-9 Fibrinogen levels; CESC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg18876405 chr7:65276391 NA -0.53 -7.16 -0.4 7.93e-12 Aortic root size; CESC cis rs4699052 0.927 rs1870888 chr4:104169326 G/C cg16532752 chr4:104119610 CENPE -0.39 -5.31 -0.31 2.27e-7 Testicular germ cell tumor; CESC cis rs1692580 0.870 rs262680 chr1:2167149 C/T cg21194808 chr1:2205498 SKI 0.39 5.76 0.33 2.38e-8 Coronary artery disease; CESC cis rs6736093 0.931 rs34974369 chr2:112683390 G/A cg12686935 chr2:112915763 FBLN7 -0.43 -5.56 -0.32 6.75e-8 Coronary artery disease; CESC cis rs6951245 0.572 rs73264010 chr7:1040477 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.56 5.1 0.3 6.34e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4319547 0.585 rs10846792 chr12:122882374 T/C cg05707623 chr12:122985044 ZCCHC8 -0.52 -5.99 -0.35 6.78e-9 Body mass index; CESC cis rs3806843 0.932 rs2563256 chr5:140141779 G/T cg26395211 chr5:140044315 WDR55 0.39 5.17 0.3 4.51e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6736093 0.763 rs11690440 chr2:112820109 G/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.5 -0.32 9.14e-8 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19110795 chr3:196159589 UBXN7 -0.41 -6.14 -0.35 3.03e-9 Gambling; CESC trans rs11098499 0.866 rs11098506 chr4:120284971 A/G cg25214090 chr10:38739885 LOC399744 0.66 8.99 0.48 4.91e-17 Corneal astigmatism; CESC cis rs4423214 1.000 rs12785878 chr11:71167449 G/T cg05163923 chr11:71159392 DHCR7 0.76 10.52 0.54 7.37e-22 Vitamin D levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07496882 chr10:112631570 LOC282997;PDCD4 -0.46 -6.08 -0.35 4.12e-9 Ulcerative colitis; CESC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg24675658 chr1:53192096 ZYG11B -0.52 -6.38 -0.36 8.06e-10 Monocyte count; CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg14893161 chr1:205819251 PM20D1 0.99 19.25 0.76 2.91e-52 Menarche (age at onset); CESC cis rs4268898 0.662 rs17789375 chr2:24502554 G/T cg06627628 chr2:24431161 ITSN2 -0.97 -11.69 -0.58 1.01e-25 Asthma; CESC cis rs2289583 0.544 rs12050759 chr15:75265191 G/A cg14664628 chr15:75095509 CSK 0.52 6.07 0.35 4.51e-9 Systemic lupus erythematosus; CESC cis rs155076 0.711 rs4769158 chr13:21881975 T/C cg25811766 chr13:21894605 NA 0.56 5.64 0.33 4.32e-8 White matter hyperintensity burden; CESC trans rs7922314 0.571 rs61865710 chr10:64735714 T/C cg06935979 chr1:232941706 KIAA1383 -0.69 -6.41 -0.37 6.71e-10 Cutaneous psoriasis; CESC cis rs9788682 0.747 rs8042059 chr15:78907859 A/C cg24631222 chr15:78858424 CHRNA5 0.77 9.28 0.5 6.25e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs9902453 0.845 rs7218113 chr17:28372130 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.69 -0.47 3.79e-16 Coffee consumption (cups per day); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02685945 chr6:22570146 HDGFL1 0.57 7.5 0.42 9.38e-13 Fibrinogen levels; CESC cis rs7520050 0.807 rs72688483 chr1:46149209 A/G cg24296786 chr1:45957014 TESK2 -0.48 -6.14 -0.35 2.96e-9 Red blood cell count;Reticulocyte count; CESC cis rs317689 0.918 rs581911 chr12:69738293 C/T cg14784868 chr12:69753453 YEATS4 0.59 6.63 0.38 1.84e-10 Response to diuretic therapy; CESC cis rs2228479 0.867 rs12919804 chr16:89945369 G/A cg06558623 chr16:89946397 TCF25 1.06 8.98 0.48 5.17e-17 Skin colour saturation; CESC cis rs9916302 0.706 rs4795385 chr17:37733148 A/G cg07936489 chr17:37558343 FBXL20 0.97 10.88 0.56 4.83e-23 Glomerular filtration rate (creatinine); CESC cis rs2932538 0.922 rs7551933 chr1:113086706 C/T cg22162597 chr1:113214053 CAPZA1 -0.58 -7.23 -0.41 5.13e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs116095464 0.558 rs2162870 chr5:228129 G/A cg22857025 chr5:266934 NA -1.28 -18.8 -0.76 1.06e-50 Breast cancer; CESC cis rs7631605 0.875 rs56198917 chr3:37017798 C/G cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.05 -0.3 8.06e-7 Cerebrospinal P-tau181p levels; CESC cis rs561341 1.000 rs7210970 chr17:30262169 G/A cg12193833 chr17:30244370 NA -0.49 -5.49 -0.32 9.5e-8 Hip circumference adjusted for BMI; CESC cis rs2040771 0.740 rs9617783 chr22:19260575 C/A cg02655711 chr22:19163373 SLC25A1 0.41 5.88 0.34 1.23e-8 Metabolite levels (small molecules and protein measures); CESC trans rs61931739 0.534 rs11053020 chr12:34111092 C/G cg26384229 chr12:38710491 ALG10B 0.6 8.45 0.46 1.98e-15 Morning vs. evening chronotype; CESC cis rs637571 0.522 rs649000 chr11:65742933 T/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.64 0.38 1.82e-10 Eosinophil percentage of white cells; CESC cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.35 5.04 0.3 8.82e-7 Schizophrenia; CESC cis rs56235845 0.694 rs4976643 chr5:176760227 A/C cg06060754 chr5:176797920 RGS14 0.41 5.13 0.3 5.5e-7 Hemoglobin concentration;Hematocrit; CESC cis rs9300255 0.566 rs10744150 chr12:123721614 A/C cg19016782 chr12:123741754 C12orf65 -0.36 -5.3 -0.31 2.43e-7 Neutrophil percentage of white cells; CESC cis rs10743315 0.557 rs74974316 chr12:19344688 A/G cg02471346 chr12:19282374 PLEKHA5 0.68 5.06 0.3 7.71e-7 Gut microbiota (bacterial taxa); CESC cis rs600231 0.706 rs10896016 chr11:65335705 C/T cg17120908 chr11:65337727 SSSCA1 0.52 5.79 0.33 2.02e-8 Bone mineral density; CESC cis rs9913156 0.707 rs72835625 chr17:4560274 G/A cg19197139 chr17:4613644 ARRB2 0.92 10.46 0.54 1.18e-21 Lymphocyte counts; CESC cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg21573476 chr21:45109991 RRP1B 0.5 6.91 0.39 3.52e-11 Mean corpuscular volume; CESC cis rs7084402 0.967 rs1593677 chr10:60291642 A/T cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -5.57 -0.32 6.2e-8 Electroencephalogram traits; CESC cis rs950776 0.518 rs12906284 chr15:78825105 C/T cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg18876405 chr7:65276391 NA -0.54 -7.06 -0.4 1.46e-11 Aortic root size; CESC cis rs2180341 0.960 rs9375503 chr6:127677071 T/C cg24812749 chr6:127587940 RNF146 1.05 15.07 0.68 1.77e-37 Breast cancer; CESC cis rs11690935 0.959 rs75922913 chr2:172620152 T/C cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.87 -0.67 9.1e-37 Schizophrenia; CESC cis rs12042052 0.793 rs12036759 chr1:232925441 A/G cg06935979 chr1:232941706 KIAA1383 0.75 6.05 0.35 4.96e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs9640161 0.663 rs1916932 chr7:150021644 T/C cg10018233 chr7:150070692 REPIN1 0.45 7.27 0.41 4.12e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs6502050 0.835 rs35857672 chr17:80078303 G/A cg23985595 chr17:80112537 CCDC57 0.41 6.54 0.37 3.19e-10 Life satisfaction; CESC cis rs6424115 0.729 rs586173 chr1:24055718 A/G cg10978503 chr1:24200527 CNR2 -0.26 -5.14 -0.3 5.3e-7 Immature fraction of reticulocytes; CESC cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg11502198 chr6:26597334 ABT1 0.52 5.34 0.31 1.99e-7 Intelligence (multi-trait analysis); CESC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg00310523 chr12:86230176 RASSF9 -0.31 -5.04 -0.3 8.55e-7 Major depressive disorder; CESC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.6 0.33 5.33e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11711311 0.955 rs9866806 chr3:113379865 C/G cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.6 -7.66 -0.43 3.42e-13 IgG glycosylation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09559324 chr16:31475905 ARMC5 0.48 6.23 0.36 1.79e-9 Fibrinogen levels; CESC trans rs12310956 0.532 rs10844720 chr12:33987859 G/T cg26384229 chr12:38710491 ALG10B 0.48 6.64 0.38 1.82e-10 Morning vs. evening chronotype; CESC trans rs1814175 0.615 rs4545557 chr11:50027329 A/C cg11707556 chr5:10655725 ANKRD33B -0.42 -6.13 -0.35 3.1e-9 Height; CESC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg02725872 chr8:58115012 NA -0.38 -5.1 -0.3 6.54e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17801256 chr1:35734334 ZMYM4 0.58 6.71 0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs796364 0.806 rs11694236 chr2:200916230 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC cis rs763121 0.819 rs5757133 chr22:38947835 A/G cg14440974 chr22:39074834 NA 0.38 5.18 0.3 4.38e-7 Menopause (age at onset); CESC trans rs656319 0.647 rs13264668 chr8:9884877 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -6.17 -0.35 2.51e-9 Myopia (pathological); CESC cis rs8114671 0.836 rs745849 chr20:33572178 G/A cg24642439 chr20:33292090 TP53INP2 -0.45 -5.35 -0.31 1.91e-7 Height; CESC cis rs10089 1.000 rs10478796 chr5:127436187 A/G cg19767477 chr5:127420684 SLC12A2 -0.42 -5.8 -0.34 1.85e-8 Ileal carcinoids; CESC cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg24308560 chr3:49941425 MST1R 0.61 8.81 0.48 1.71e-16 Intelligence (multi-trait analysis); CESC cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg26597838 chr10:835615 NA 0.83 8.95 0.48 6.34e-17 Eosinophil percentage of granulocytes; CESC cis rs10911251 0.527 rs1537520 chr1:183084229 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 14.02 0.65 8.78e-34 Colorectal cancer; CESC cis rs611744 0.647 rs6981420 chr8:109266694 T/G cg21045802 chr8:109455806 TTC35 0.48 5.99 0.35 6.89e-9 Dupuytren's disease; CESC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.65 -0.38 1.72e-10 Bipolar disorder; CESC cis rs752010 0.714 rs10890144 chr1:42085397 G/T cg06885757 chr1:42089581 HIVEP3 0.51 8.81 0.48 1.66e-16 Lupus nephritis in systemic lupus erythematosus; CESC cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.57 -7.48 -0.42 1.09e-12 Tonsillectomy; CESC cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg14784868 chr12:69753453 YEATS4 0.83 12.94 0.62 5.03e-30 Blood protein levels; CESC cis rs6912958 0.525 rs586771 chr6:88064971 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.34 5.75 0.33 2.48e-8 Monocyte percentage of white cells; CESC cis rs847577 0.677 rs10242903 chr7:97741795 C/T cg24562669 chr7:97807699 LMTK2 -0.57 -8.36 -0.46 3.53e-15 Breast cancer; CESC cis rs8133932 0.654 rs410902 chr21:47341794 G/A cg14185626 chr21:47401492 COL6A1 -0.45 -5.09 -0.3 6.84e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13076329 chr4:114682704 CAMK2D 0.62 6.82 0.39 6.15e-11 Gut microbiome composition (summer); CESC cis rs7647973 1.000 rs3866330 chr3:49582994 T/C cg07636037 chr3:49044803 WDR6 0.7 10.34 0.54 2.84e-21 Menarche (age at onset); CESC cis rs13242816 1.000 rs35505552 chr7:116104867 T/A cg04696780 chr7:116139425 CAV2 -0.62 -5.69 -0.33 3.31e-8 P wave duration; CESC cis rs7647973 1.000 rs6805609 chr3:49471522 C/G cg07636037 chr3:49044803 WDR6 -0.65 -8.06 -0.44 2.68e-14 Menarche (age at onset); CESC cis rs7429990 0.813 rs7627568 chr3:48093052 A/T cg11946769 chr3:48343235 NME6 -0.45 -5.4 -0.31 1.51e-7 Educational attainment (years of education); CESC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg18190219 chr22:46762943 CELSR1 -0.58 -6.63 -0.38 1.91e-10 LDL cholesterol;Cholesterol, total; CESC cis rs7635838 0.684 rs2606762 chr3:11343889 G/C cg00170343 chr3:11313890 ATG7 0.54 7.65 0.43 3.71e-13 HDL cholesterol; CESC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg17178900 chr1:205818956 PM20D1 0.39 5.28 0.31 2.65e-7 Prostate-specific antigen levels; CESC cis rs644799 1.000 rs568668 chr11:95528209 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.52 6.29 0.36 1.32e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4979906 1.000 rs1609790 chr10:79464078 C/T cg07817648 chr10:79422355 NA -0.55 -5.88 -0.34 1.21e-8 Mortality in heart failure; CESC cis rs7584330 0.657 rs10202599 chr2:238352465 A/C cg14458575 chr2:238380390 NA 0.64 8.81 0.48 1.7e-16 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03532930 chr1:2246464 NA 0.54 6.18 0.35 2.39e-9 Gut microbiome composition (summer); CESC cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg15017067 chr4:17643749 FAM184B 0.38 5.06 0.3 7.86e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7267979 0.933 rs2258728 chr20:25276343 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.69 0.75 2.61e-50 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06310022 chr3:114095810 ZBTB20 -0.59 -7.15 -0.4 8.26e-12 Gut microbiome composition (summer); CESC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg22307029 chr19:49891270 CCDC155 0.7 8.38 0.46 3.2e-15 Multiple sclerosis; CESC cis rs12824058 0.831 rs7979497 chr12:130804706 C/T cg26677194 chr12:130822605 PIWIL1 0.49 6.24 0.36 1.74e-9 Menopause (age at onset); CESC cis rs2479724 0.811 rs6905726 chr6:41750812 T/C cg17623882 chr6:41773611 USP49 0.41 5.57 0.32 6.22e-8 Menarche (age at onset); CESC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg06453172 chr10:134556979 INPP5A -0.41 -5.35 -0.31 1.91e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg25985355 chr7:65971099 NA -0.32 -5.32 -0.31 2.16e-7 Aortic root size; CESC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg25036284 chr2:26402008 FAM59B 0.86 9.36 0.5 3.44e-18 Gut microbiome composition (summer); CESC cis rs6570726 0.846 rs426874 chr6:145880630 A/C cg05347473 chr6:146136440 FBXO30 0.49 6.46 0.37 4.91e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs959260 0.688 rs4789173 chr17:73349497 T/C cg20590849 chr17:73267439 MIF4GD -0.56 -6.11 -0.35 3.55e-9 Systemic lupus erythematosus; CESC cis rs10465746 0.725 rs12070578 chr1:84349607 A/G cg10977910 chr1:84465055 TTLL7 0.56 7.74 0.43 2.09e-13 Obesity-related traits; CESC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg07167872 chr1:205819463 PM20D1 0.4 5.5 0.32 8.95e-8 Menarche (age at onset); CESC cis rs4253772 0.701 rs9627280 chr22:46643964 T/C cg24881330 chr22:46731750 TRMU 0.73 8.07 0.44 2.51e-14 LDL cholesterol;Cholesterol, total; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13474011 chr10:49515374 NA 0.5 6.54 0.37 3.11e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2439831 0.681 rs825740 chr15:43592408 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.89 13.12 0.63 1.22e-30 Lung cancer in ever smokers; CESC cis rs12497850 0.931 rs6446253 chr3:48911443 C/T cg06212747 chr3:49208901 KLHDC8B 0.67 9.12 0.49 1.91e-17 Parkinson's disease; CESC cis rs950776 0.518 rs12902493 chr15:78819275 C/G cg24631222 chr15:78858424 CHRNA5 -0.41 -5.23 -0.31 3.48e-7 Sudden cardiac arrest; CESC cis rs4819052 0.851 rs2255774 chr21:46683851 A/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.68 9.68 0.51 3.61e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9346455 1.000 rs9354986 chr6:71996205 G/C cg27238071 chr6:71998145 OGFRL1 0.56 5.08 0.3 7e-7 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs6028335 0.610 rs6729 chr20:37668272 A/G cg16355469 chr20:37678765 NA 0.52 5.13 0.3 5.47e-7 Alcohol and nicotine co-dependence; CESC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg12963246 chr6:28129442 ZNF389 0.51 6.66 0.38 1.59e-10 Depression; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25215298 chr1:860022 SAMD11 -0.47 -6.49 -0.37 4.18e-10 Ulcerative colitis; CESC cis rs79349575 0.715 rs4793997 chr17:47019672 C/A cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg26338869 chr17:61819248 STRADA 0.67 8.78 0.47 2.04e-16 Prudent dietary pattern; CESC cis rs4523957 0.547 rs11078856 chr17:2092064 G/A cg16513277 chr17:2031491 SMG6 -0.64 -8.96 -0.48 6.1e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20723414 chr7:157207071 DNAJB6 -0.56 -6.01 -0.35 5.96e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg26338869 chr17:61819248 STRADA 0.7 9.3 0.5 5.3e-18 Prudent dietary pattern; CESC cis rs7296418 0.619 rs7139321 chr12:123719528 T/G cg05973401 chr12:123451056 ABCB9 0.49 6.34 0.36 9.63e-10 Platelet count; CESC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg26335602 chr6:28129616 ZNF389 0.55 7.34 0.41 2.57e-12 Depression; CESC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg17340268 chr14:105411764 AHNAK2 -0.52 -6.91 -0.39 3.56e-11 Rheumatoid arthritis; CESC cis rs1144713 0.686 rs1144714 chr12:32261252 A/C cg01321189 chr12:32259338 BICD1 0.34 5.17 0.3 4.67e-7 Obesity-related traits; CESC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg19592336 chr6:28129416 ZNF389 0.58 7.71 0.43 2.54e-13 Depression; CESC cis rs9837602 0.529 rs793458 chr3:99520169 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.52 -6.21 -0.36 2.05e-9 Breast cancer; CESC cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg20891558 chr2:74357851 NA 0.8 11.63 0.58 1.59e-25 Gestational age at birth (maternal effect); CESC cis rs4654899 1.000 rs6684976 chr1:21367501 G/A cg05370193 chr1:21551575 ECE1 0.39 5.85 0.34 1.47e-8 Superior frontal gyrus grey matter volume; CESC cis rs2439831 1.000 rs561863 chr15:43761352 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.58 0.54 4.72e-22 Lung cancer in ever smokers; CESC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg18225595 chr11:63971243 STIP1 0.57 5.8 0.34 1.88e-8 Mean platelet volume; CESC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg07308232 chr7:1071921 C7orf50 -0.43 -6.06 -0.35 4.66e-9 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16600432 chr14:64970085 ZBTB1;ZBTB25 0.54 6.66 0.38 1.53e-10 Gut microbiome composition (summer); CESC cis rs7402982 0.647 rs34038360 chr15:99201573 A/C cg03437748 chr15:99193247 IGF1R 0.6 8.01 0.44 3.6e-14 Birth weight; CESC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg05863683 chr7:1912471 MAD1L1 0.37 5.49 0.32 9.51e-8 Bipolar disorder and schizophrenia; CESC cis rs11122272 0.735 rs2739510 chr1:231526718 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.73 -0.43 2.3e-13 Hemoglobin concentration; CESC cis rs796364 0.865 rs769948 chr2:200728475 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 8.19 0.45 1.12e-14 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24078387 chr1:53704033 MAGOH 0.65 7.15 0.4 8.47e-12 Gut microbiome composition (summer); CESC cis rs6087990 0.806 rs6141814 chr20:31368960 C/A cg13636640 chr20:31349939 DNMT3B 0.81 12.5 0.61 1.67e-28 Ulcerative colitis; CESC cis rs77106637 0.929 rs1059000 chr11:72504972 G/C cg04827223 chr11:72435913 ARAP1 -0.56 -5.77 -0.33 2.16e-8 Type 2 diabetes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00670465 chr12:511362 CCDC77 0.5 7.04 0.4 1.66e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs453301 0.653 rs1045529 chr8:8890098 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -5.93 -0.34 9.43e-9 Joint mobility (Beighton score); CESC cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.73 10.43 0.54 1.49e-21 Monocyte percentage of white cells; CESC cis rs12142240 0.698 rs68112720 chr1:46813888 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11166252 chr7:17338258 AHR 0.63 7.69 0.43 2.81e-13 Gut microbiome composition (summer); CESC cis rs6500395 1.000 rs28577888 chr16:48673281 T/G cg04672837 chr16:48644449 N4BP1 0.5 6.19 0.36 2.32e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs62103177 0.733 rs62103193 chr18:77629217 C/T cg12964065 chr18:77638022 KCNG2 0.58 5.46 0.32 1.07e-7 Opioid sensitivity; CESC cis rs9549260 0.755 rs4943798 chr13:41202948 T/C cg21288729 chr13:41239152 FOXO1 0.64 8.24 0.45 8.16e-15 Red blood cell count; CESC cis rs9976767 0.637 rs9325635 chr21:43823289 G/A cg23042151 chr21:43824109 UBASH3A -0.32 -6.01 -0.35 6.25e-9 Type 1 diabetes; CESC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg11663144 chr21:46675770 NA -0.58 -8.57 -0.47 8.75e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12142240 0.738 rs67545510 chr1:46806242 G/T cg10495392 chr1:46806563 NSUN4 0.59 6.36 0.36 8.9e-10 Menopause (age at onset); CESC cis rs6496667 0.954 rs7162211 chr15:90892585 G/C cg22089800 chr15:90895588 ZNF774 0.5 5.03 0.3 9.07e-7 Rheumatoid arthritis; CESC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg14393609 chr7:65229607 NA -0.41 -5.77 -0.33 2.21e-8 Aortic root size; CESC cis rs6460942 0.597 rs17545416 chr7:12525944 A/T cg02935154 chr7:12443704 VWDE -0.55 -5.53 -0.32 7.71e-8 Coronary artery disease; CESC cis rs13392177 0.684 rs11682371 chr2:219079513 G/A cg00012203 chr2:219082015 ARPC2 -0.66 -8.16 -0.45 1.32e-14 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs208520 0.802 rs208499 chr6:66932146 C/T cg07460842 chr6:66804631 NA -0.82 -10.01 -0.52 3.23e-20 Exhaled nitric oxide output; CESC cis rs7927592 0.731 rs11228288 chr11:68353550 A/G cg01657329 chr11:68192670 LRP5 -0.47 -6.12 -0.35 3.37e-9 Total body bone mineral density; CESC cis rs2760061 0.626 rs635563 chr1:228136834 C/T cg02753203 chr1:228287806 NA -0.5 -7.36 -0.41 2.27e-12 Diastolic blood pressure; CESC cis rs6701037 0.714 rs2285219 chr1:175130983 A/T cg00321850 chr1:175162397 KIAA0040 -0.42 -6.14 -0.35 3.03e-9 Alcohol dependence; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg23104823 chr14:45553408 PRPF39 0.49 6.76 0.38 8.87e-11 Systemic lupus erythematosus; CESC cis rs7208859 0.573 rs79505916 chr17:29062326 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.33 0.36 1.06e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs7618501 1.000 rs7431106 chr3:49808374 G/A cg21659725 chr3:3221576 CRBN 0.83 13.63 0.64 2.04e-32 Intelligence (multi-trait analysis); CESC cis rs4555082 0.834 rs2735825 chr14:105710900 G/A cg13114125 chr14:105738426 BRF1 -0.87 -10.38 -0.54 2.08e-21 Mean platelet volume;Platelet distribution width; CESC cis rs7662987 1.000 rs7684986 chr4:99991676 C/T cg13256891 chr4:100009986 ADH5 -0.83 -5.86 -0.34 1.38e-8 Smoking initiation; CESC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.5 -0.32 9.08e-8 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg19592336 chr6:28129416 ZNF389 0.62 8.12 0.45 1.77e-14 Depression; CESC cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg22875332 chr1:76189707 ACADM 0.7 9.65 0.51 4.56e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg18876405 chr7:65276391 NA 0.47 5.73 0.33 2.76e-8 Aortic root size; CESC cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg02487422 chr3:49467188 NICN1 0.4 5.15 0.3 5.11e-7 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09324016 chr16:31085582 ZNF668;ZNF646 -0.65 -8.12 -0.45 1.79e-14 Gut microbiome composition (summer); CESC cis rs2304069 0.779 rs245081 chr5:149356075 G/T cg12661370 chr5:149340060 SLC26A2 0.46 5.49 0.32 9.33e-8 HIV-1 control; CESC cis rs6087990 0.735 rs910083 chr20:31378690 A/C cg13636640 chr20:31349939 DNMT3B 0.8 13.22 0.63 5.39e-31 Ulcerative colitis; CESC cis rs1030268 0.667 rs12707111 chr7:133330144 C/T cg10665199 chr7:133106180 EXOC4 0.51 5.42 0.32 1.37e-7 Intelligence (multi-trait analysis); CESC cis rs9549367 0.789 rs2302754 chr13:113898385 C/T cg18105134 chr13:113819100 PROZ 0.67 8.3 0.45 5.25e-15 Platelet distribution width; CESC trans rs1994135 0.647 rs66542958 chr12:33695385 T/G cg26384229 chr12:38710491 ALG10B 0.46 6.37 0.36 8.12e-10 Resting heart rate; CESC cis rs7259376 0.875 rs1975175 chr19:22515239 G/C cg02657401 chr19:22469223 NA -0.26 -5.26 -0.31 3.01e-7 Menopause (age at onset); CESC cis rs8016982 0.963 rs2099108 chr14:81675420 C/G cg01989461 chr14:81687754 GTF2A1 0.56 7.3 0.41 3.46e-12 Schizophrenia; CESC cis rs116095464 0.558 rs6555052 chr5:224268 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.65 0.33 4.24e-8 Breast cancer; CESC cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg06484146 chr7:12443880 VWDE -0.68 -9.39 -0.5 2.86e-18 Coronary artery disease; CESC trans rs113577745 0.725 rs16867277 chr2:10136592 T/C cg12379383 chr15:96896940 NA -0.57 -6.17 -0.35 2.56e-9 Breast cancer; CESC cis rs2404602 0.647 rs1443115 chr15:77041829 T/C cg23625390 chr15:77176239 SCAPER -0.4 -5.2 -0.3 4e-7 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01293050 chr14:20937714 PNP 0.53 6.12 0.35 3.38e-9 Gut microbiome composition (summer); CESC cis rs10992471 0.756 rs10992303 chr9:95082804 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.44 -5.57 -0.32 6.3e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 5.86e-30 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.819 rs5757169 chr22:39003495 G/A cg06022373 chr22:39101656 GTPBP1 0.95 17.17 0.73 6.29e-45 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22046830 chr8:145133508 EXOSC4 0.54 6.37 0.36 8.49e-10 Gut microbiome composition (summer); CESC cis rs329122 0.528 rs329113 chr5:133856408 A/G cg26284174 chr5:133860141 NA 0.45 5.24 0.31 3.34e-7 Body mass index;Type 2 diabetes; CESC cis rs60154123 0.730 rs608791 chr1:210464638 C/T cg21951975 chr1:209979733 IRF6 0.45 6.03 0.35 5.39e-9 Coronary artery disease; CESC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -7.13 -0.4 9.34e-12 Extrinsic epigenetic age acceleration; CESC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg05368731 chr17:41323189 NBR1 0.76 10.45 0.54 1.21e-21 Menopause (age at onset); CESC cis rs734999 0.545 rs12752515 chr1:2564465 T/C cg18854424 chr1:2615690 NA -0.31 -5.91 -0.34 1.08e-8 Ulcerative colitis; CESC cis rs3747547 0.892 rs11789186 chr9:37975114 A/C cg13774184 chr9:37916125 SHB -0.68 -5.85 -0.34 1.47e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs7296418 0.961 rs12425850 chr12:123501972 T/C cg05973401 chr12:123451056 ABCB9 0.58 7.62 0.42 4.54e-13 Platelet count; CESC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg17372223 chr3:52568218 NT5DC2 0.44 6.46 0.37 4.87e-10 Bipolar disorder; CESC cis rs9733 0.744 rs12126004 chr1:150889877 T/C cg13175981 chr1:150552382 MCL1 0.53 7.11 0.4 1.09e-11 Tonsillectomy; CESC trans rs57221529 0.766 rs4081846 chr5:574019 G/A cg25482853 chr8:67687455 SGK3 1.01 10.13 0.53 1.39e-20 Lung disease severity in cystic fibrosis; CESC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg16405210 chr4:1374714 KIAA1530 0.75 10.47 0.54 1.09e-21 Obesity-related traits; CESC cis rs6987853 0.602 rs2974337 chr8:42390873 C/T cg09913449 chr8:42400586 C8orf40 0.33 5.08 0.3 7.06e-7 Mean corpuscular hemoglobin concentration; CESC cis rs12950390 0.853 rs11655112 chr17:45856563 T/C cg00777063 chr17:45855553 NA -0.39 -5.77 -0.33 2.26e-8 IgG glycosylation; CESC cis rs4237845 0.837 rs7954591 chr12:58299037 A/G cg02175503 chr12:58329896 NA 0.65 9.29 0.5 5.97e-18 Intelligence (multi-trait analysis); CESC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg27266027 chr21:40555129 PSMG1 0.44 5.25 0.31 3.16e-7 Cognitive function; CESC cis rs4604732 0.631 rs74154673 chr1:247625629 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15985400 chr11:76091674 PRKRIR 0.67 7.48 0.42 1.13e-12 Gut microbiome composition (summer); CESC cis rs11792861 0.589 rs75742991 chr9:111929624 C/G cg05043794 chr9:111880884 C9orf5 -0.41 -6.25 -0.36 1.67e-9 Menarche (age at onset); CESC cis rs734999 0.566 rs4648658 chr1:2560882 G/A cg18854424 chr1:2615690 NA -0.29 -5.92 -0.34 1e-8 Ulcerative colitis; CESC trans rs4932480 0.522 rs4932215 chr15:89746132 C/G cg24069674 chr6:27230661 NA -0.42 -6.58 -0.37 2.56e-10 Advanced age-related macular degeneration;Age-related macular degeneration (SNP x mitochondrial G12771A interaction); CESC cis rs9902453 0.791 rs62068629 chr17:28187596 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.21 0.45 9.9e-15 Coffee consumption (cups per day); CESC cis rs4835473 0.838 rs10024263 chr4:144959327 A/G cg25736465 chr4:144833511 NA 0.44 6.74 0.38 9.91e-11 Immature fraction of reticulocytes; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg18337363 chr3:52569053 NT5DC2 0.31 6.07 0.35 4.5e-9 Bipolar disorder; CESC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg21782813 chr7:2030301 MAD1L1 0.36 5.05 0.3 8.41e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7772486 0.805 rs4896831 chr6:145959481 T/C cg23711669 chr6:146136114 FBXO30 0.82 11.91 0.59 1.77e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs9549367 0.789 rs6577035 chr13:113879997 G/A cg18105134 chr13:113819100 PROZ -0.66 -8.24 -0.45 8.04e-15 Platelet distribution width; CESC cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg21226059 chr5:178986404 RUFY1 0.49 7.57 0.42 6.27e-13 Lung cancer; CESC cis rs3780486 0.801 rs56687083 chr9:33132134 A/G cg13443165 chr9:33130375 B4GALT1 0.45 6.46 0.37 5e-10 IgG glycosylation; CESC cis rs977987 0.806 rs6564258 chr16:75447363 G/A cg03315344 chr16:75512273 CHST6 0.41 5.83 0.34 1.59e-8 Dupuytren's disease; CESC cis rs796364 0.806 rs11674293 chr2:201026743 G/A cg23649088 chr2:200775458 C2orf69 -0.6 -5.16 -0.3 4.78e-7 Schizophrenia; CESC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -8.18 -0.45 1.19e-14 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg23978390 chr7:1156363 C7orf50 0.5 6.79 0.38 7.43e-11 Longevity;Endometriosis; CESC cis rs6835098 1.000 rs6826412 chr4:174109622 C/T cg08422745 chr4:174089978 GALNT7 -0.72 -9.42 -0.5 2.4e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00878827 chr14:75229987 YLPM1 0.58 7.2 0.4 6.39e-12 Gut microbiome composition (summer); CESC cis rs3767633 0.858 rs2341468 chr1:161862312 G/A cg09175582 chr1:161736000 ATF6 0.85 6.91 0.39 3.53e-11 IgG glycosylation; CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg18099408 chr3:52552593 STAB1 -0.36 -6.59 -0.38 2.39e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17104843 chr1:213032108 FLVCR1;LQK1 0.56 6.39 0.37 7.63e-10 Gut microbiome composition (summer); CESC cis rs6500395 1.000 rs9936004 chr16:48566088 A/G cg04672837 chr16:48644449 N4BP1 0.49 6.16 0.35 2.68e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7903847 0.642 rs10882923 chr10:99159018 G/A cg20016023 chr10:99160130 RRP12 -0.3 -5.22 -0.31 3.54e-7 Granulocyte percentage of myeloid white cells; CESC cis rs6732160 0.510 rs57825971 chr2:73384796 C/G cg01422370 chr2:73384389 NA 0.46 7.27 0.41 4.11e-12 Intelligence (multi-trait analysis); CESC trans rs4950322 0.518 rs4950305 chr1:146589293 C/A cg04954894 chr8:38089920 DDHD2 -0.59 -6.42 -0.37 6.13e-10 Protein quantitative trait loci; CESC cis rs7833986 0.501 rs2719233 chr8:56886156 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.57 6.94 0.39 3.07e-11 Height; CESC cis rs3862435 0.572 rs2589967 chr15:90907876 T/C cg22089800 chr15:90895588 ZNF774 0.5 5.5 0.32 8.81e-8 Response to exercise (triglyceride level interaction); CESC cis rs832540 0.931 rs832535 chr5:56213334 C/T cg14703610 chr5:56206110 C5orf35 0.53 7.03 0.4 1.78e-11 Coronary artery disease; CESC trans rs8073060 0.586 rs7217533 chr17:34015876 A/G cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs9329289 0.926 rs9329290 chr10:2542751 G/T cg05625103 chr10:2543513 NA 0.37 5.17 0.3 4.52e-7 Age-related hearing impairment; CESC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg06718696 chr17:78121285 EIF4A3 0.42 5.32 0.31 2.19e-7 Yeast infection; CESC cis rs8067354 0.872 rs1292060 chr17:57913849 A/G cg02344993 chr17:57696989 CLTC 0.47 6.13 0.35 3.16e-9 Hemoglobin concentration; CESC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg18252515 chr7:66147081 NA 0.43 5.74 0.33 2.57e-8 Aortic root size; CESC cis rs11711311 0.869 rs1026364 chr3:113370010 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.24 0.36 1.74e-9 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05865860 chr7:158649142 WDR60 0.58 6.61 0.38 2.1e-10 Gut microbiome composition (summer); CESC cis rs929354 0.742 rs2107863 chr7:156963731 T/C cg05182265 chr7:156933206 UBE3C -0.5 -7.3 -0.41 3.28e-12 Body mass index; CESC cis rs2204008 0.627 rs1851117 chr12:38398987 G/T cg13010199 chr12:38710504 ALG10B 0.48 6.05 0.35 4.85e-9 Bladder cancer; CESC cis rs2073300 0.609 rs6137920 chr20:23363436 C/T cg12062639 chr20:23401060 NAPB 1.08 8.67 0.47 4.32e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2839186 0.585 rs2839154 chr21:47637760 C/T cg11766577 chr21:47581405 C21orf56 0.4 5.19 0.3 4.22e-7 Testicular germ cell tumor; CESC trans rs61931739 0.534 rs28548399 chr12:34188151 G/A cg26384229 chr12:38710491 ALG10B 0.65 9.11 0.49 2.1e-17 Morning vs. evening chronotype; CESC cis rs5769765 0.954 rs910799 chr22:50278568 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.48 5.62 0.33 4.93e-8 Schizophrenia; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg07667813 chr19:7985168 SNAPC2 0.47 6.34 0.36 1.01e-9 Height; CESC trans rs324780 0.544 rs3103509 chr12:83889162 C/T cg22140261 chr22:42466895 NAGA 0.47 6.03 0.35 5.38e-9 Vertical cup-disc ratio; CESC cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg05283184 chr6:79620031 NA -0.43 -6.62 -0.38 1.97e-10 Intelligence (multi-trait analysis); CESC cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.86 7.4 0.41 1.79e-12 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14012564 chr10:47133876 LOC728643 -0.5 -6.29 -0.36 1.32e-9 Gut microbiome composition (summer); CESC cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg05347473 chr6:146136440 FBXO30 0.59 7.56 0.42 6.43e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs858239 0.600 rs6461692 chr7:23139695 G/C cg23682824 chr7:23144976 KLHL7 0.53 7.3 0.41 3.46e-12 Cerebrospinal fluid biomarker levels; CESC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.31 0.36 1.14e-9 Bipolar disorder; CESC cis rs2742234 0.666 rs715106 chr10:43616751 C/A cg15436174 chr10:43711423 RASGEF1A -0.47 -5.48 -0.32 1.01e-7 Hirschsprung disease; CESC cis rs3008870 0.755 rs1024230 chr1:67512920 A/C cg02640540 chr1:67518911 SLC35D1 0.71 9.16 0.49 1.46e-17 Lymphocyte percentage of white cells; CESC cis rs7520050 0.966 rs785479 chr1:46492144 C/T cg24296786 chr1:45957014 TESK2 0.43 5.44 0.32 1.2e-7 Red blood cell count;Reticulocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19071989 chr7:2566113 LFNG -0.4 -6.68 -0.38 1.42e-10 Gambling; CESC trans rs9467711 0.606 rs9358932 chr6:26362705 A/G cg06606381 chr12:133084897 FBRSL1 0.75 7.0 0.4 2.08e-11 Autism spectrum disorder or schizophrenia; CESC cis rs911555 0.673 rs7144271 chr14:103890674 A/G cg09975044 chr14:104007538 NA 0.44 5.6 0.33 5.39e-8 Intelligence (multi-trait analysis); CESC trans rs9886428 0.531 rs34803352 chr8:14042304 T/C cg20900203 chr3:65748129 MAGI1 0.47 6.01 0.35 5.96e-9 IgG glycosylation; CESC cis rs9325144 0.560 rs12424821 chr12:38649951 C/T cg26384229 chr12:38710491 ALG10B -0.6 -8.54 -0.46 1.05e-15 Morning vs. evening chronotype; CESC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg07701084 chr6:150067640 NUP43 0.43 5.83 0.34 1.62e-8 Lung cancer; CESC cis rs4481887 0.962 rs10788770 chr1:248457474 T/G cg00666640 chr1:248458726 OR2T12 0.42 7.01 0.4 1.98e-11 Common traits (Other); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08042487 chr21:45739921 PFKL 0.51 6.86 0.39 4.74e-11 Fibrinogen levels; CESC cis rs9309473 0.898 rs28879089 chr2:73812886 G/A cg20560298 chr2:73613845 ALMS1 -0.54 -7.1 -0.4 1.13e-11 Metabolite levels; CESC cis rs7937682 0.564 rs11600652 chr11:111754368 A/T cg22437258 chr11:111473054 SIK2 -0.48 -5.31 -0.31 2.31e-7 Primary sclerosing cholangitis; CESC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg05368731 chr17:41323189 NBR1 0.8 10.68 0.55 2.21e-22 Menopause (age at onset); CESC cis rs939658 0.805 rs59104559 chr15:79438784 A/G cg17916960 chr15:79447300 NA -0.35 -5.96 -0.34 8.11e-9 Refractive error; CESC cis rs367943 0.698 rs2217296 chr5:112973829 A/T cg12552261 chr5:112820674 MCC 0.43 5.49 0.32 9.31e-8 Type 2 diabetes; CESC cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg20307385 chr11:47447363 PSMC3 -0.53 -6.43 -0.37 6.04e-10 Subjective well-being; CESC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg07507251 chr3:52567010 NT5DC2 0.32 5.5 0.32 8.74e-8 Bipolar disorder; CESC cis rs11039131 0.629 rs67871383 chr11:47335838 T/C cg05585544 chr11:47624801 NA -0.36 -5.08 -0.3 7.13e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19412675 chr5:122181750 SNX24 -0.53 -6.13 -0.35 3.11e-9 Gut microbiome composition (summer); CESC cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.56 0.37 2.8e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg13798912 chr7:905769 UNC84A 0.6 5.98 0.34 7.1e-9 Cerebrospinal P-tau181p levels; CESC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg07677032 chr17:61819896 STRADA 0.41 5.3 0.31 2.41e-7 Prudent dietary pattern; CESC cis rs1692580 0.840 rs262679 chr1:2169792 C/T cg21194808 chr1:2205498 SKI 0.39 5.43 0.32 1.27e-7 Coronary artery disease; CESC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg21433313 chr16:3507492 NAT15 -0.55 -9.5 -0.5 1.3e-18 Tuberculosis; CESC cis rs12079745 0.793 rs10919110 chr1:169214293 G/C cg09363564 chr1:169337483 NME7;BLZF1 -1.01 -6.29 -0.36 1.31e-9 QT interval; CESC cis rs12586317 0.620 rs8020370 chr14:35581432 G/A cg16230307 chr14:35515116 FAM177A1 0.92 10.08 0.53 1.98e-20 Psoriasis; CESC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg16680214 chr1:154839983 KCNN3 -0.49 -7.54 -0.42 7.48e-13 Prostate cancer; CESC cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg23711669 chr6:146136114 FBXO30 -1.01 -15.52 -0.69 4.34e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.15e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7795096 1.000 rs7795096 chr7:151546589 A/G cg17008978 chr7:151542804 PRKAG2 0.3 5.55 0.32 7.05e-8 Bipolar disorder (age of onset and psychotic symptoms); CESC cis rs9831754 1.000 rs9831754 chr3:78353591 A/C cg06138941 chr3:78371609 NA -0.75 -8.85 -0.48 1.3e-16 Calcium levels; CESC cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg26408565 chr15:76604113 ETFA 0.37 5.35 0.31 1.88e-7 Blood metabolite levels; CESC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.46 6.49 0.37 4.3e-10 Bipolar disorder; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg16177875 chr15:49102732 CEP152 -0.4 -6.15 -0.35 2.82e-9 Vertical cup-disc ratio; CESC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg25517755 chr10:38738941 LOC399744 -0.49 -6.43 -0.37 6.04e-10 Extrinsic epigenetic age acceleration; CESC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg15445000 chr17:37608096 MED1 -0.4 -6.5 -0.37 3.9e-10 Glomerular filtration rate (creatinine); CESC cis rs9322193 0.566 rs9397070 chr6:150243209 T/C cg01145232 chr6:150245071 RAET1G -0.54 -7.09 -0.4 1.24e-11 Lung cancer; CESC cis rs17881320 0.510 rs7221385 chr17:40562081 C/T cg05878104 chr17:40932452 WNK4 -0.53 -5.49 -0.32 9.56e-8 Atopic dermatitis; CESC cis rs7927771 1.000 rs10838738 chr11:47663049 A/G cg18512352 chr11:47633146 NA -0.62 -9.81 -0.52 1.35e-19 Subjective well-being; CESC cis rs798554 0.679 rs798499 chr7:2792013 G/A cg19717773 chr7:2847554 GNA12 -0.55 -8.76 -0.47 2.37e-16 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25023241 chr1:26560532 CCDC21 0.6 6.55 0.37 3.01e-10 Gut microbiome composition (summer); CESC cis rs6842047 1.000 rs6842047 chr4:187133576 A/C cg23442198 chr4:187126114 CYP4V2 0.6 5.26 0.31 2.91e-7 Blood protein levels; CESC cis rs4237845 0.742 rs3751330 chr12:58290226 T/C cg00677455 chr12:58241039 CTDSP2 0.43 5.7 0.33 3.26e-8 Intelligence (multi-trait analysis); CESC cis rs10870270 0.830 rs10781571 chr10:133774316 G/C cg26149184 chr10:133730230 NA 0.38 5.1 0.3 6.63e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2228479 0.850 rs62052660 chr16:89847420 T/A cg00800038 chr16:89945340 TCF25 -0.9 -7.51 -0.42 9.11e-13 Skin colour saturation; CESC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg12193833 chr17:30244370 NA 0.54 5.46 0.32 1.09e-7 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13169780 chr17:7591570 TP53;WRAP53 -0.65 -7.98 -0.44 4.31e-14 Gut microbiome composition (summer); CESC cis rs748404 0.631 rs7163288 chr15:43671355 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.61 9.6 0.51 6.29e-19 Lung cancer; CESC cis rs7617773 0.817 rs3937 chr3:48312402 T/C cg11946769 chr3:48343235 NME6 0.8 10.58 0.54 4.71e-22 Coronary artery disease; CESC trans rs605920 0.561 rs661913 chr18:62751108 A/G cg26619099 chr11:68973615 NA -0.42 -6.08 -0.35 4.08e-9 Cardiac Troponin-T levels; CESC cis rs6750795 0.870 rs6754952 chr2:232381245 G/T cg19187155 chr2:232395269 NMUR1 -0.65 -11.64 -0.58 1.48e-25 Height; CESC cis rs4919087 0.748 rs701819 chr10:98986316 C/A cg25902810 chr10:99078978 FRAT1 -0.5 -5.59 -0.32 5.53e-8 Monocyte count; CESC cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg18512352 chr11:47633146 NA -0.63 -9.89 -0.52 8.02e-20 Subjective well-being; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg05780616 chr12:96252764 SNRPF 0.45 6.15 0.35 2.84e-9 Systemic lupus erythematosus; CESC cis rs1218582 0.600 rs72702224 chr1:154911689 G/A cg09359103 chr1:154839909 KCNN3 -0.6 -10.37 -0.54 2.32e-21 Prostate cancer; CESC cis rs7520050 0.807 rs12025621 chr1:46228391 G/A cg24296786 chr1:45957014 TESK2 0.46 5.99 0.35 6.97e-9 Red blood cell count;Reticulocyte count; CESC cis rs329122 0.528 rs11242218 chr5:133848688 G/T cg26284174 chr5:133860141 NA 0.45 5.13 0.3 5.62e-7 Body mass index;Type 2 diabetes; CESC cis rs9815354 0.812 rs11129935 chr3:41985203 A/C cg03022575 chr3:42003672 ULK4 0.68 6.1 0.35 3.75e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27527783 chr7:55540112 VOPP1 -0.52 -6.15 -0.35 2.9e-9 Gut microbiome composition (summer); CESC cis rs9309473 0.950 rs6756885 chr2:73805172 A/G cg20560298 chr2:73613845 ALMS1 -0.54 -7.03 -0.4 1.76e-11 Metabolite levels; CESC cis rs7259376 0.729 rs3867187 chr19:22570220 C/G cg02657401 chr19:22469223 NA -0.27 -5.31 -0.31 2.31e-7 Menopause (age at onset); CESC cis rs9715521 0.900 rs62299249 chr4:59824174 G/A cg11281224 chr4:60001000 NA -0.51 -6.67 -0.38 1.45e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs72781680 0.699 rs72794291 chr2:23897935 C/T cg08917208 chr2:24149416 ATAD2B 1.17 10.79 0.55 9.42e-23 Lymphocyte counts; CESC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg22920501 chr2:26401640 FAM59B -0.79 -9.59 -0.51 6.87e-19 Gut microbiome composition (summer); CESC cis rs7560272 0.723 rs7585119 chr2:73724679 A/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.83 -0.39 5.8e-11 Schizophrenia; CESC cis rs72634258 0.503 rs707457 chr1:7831064 C/A cg26816564 chr1:7831052 VAMP3 0.74 6.94 0.39 3.09e-11 Inflammatory bowel disease; CESC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg21782813 chr7:2030301 MAD1L1 -0.5 -7.37 -0.41 2.22e-12 Bipolar disorder and schizophrenia; CESC cis rs34779708 0.931 rs72789687 chr10:35372489 G/A cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg26420824 chr1:28562883 ATPIF1 0.47 6.11 0.35 3.63e-9 Thyroid stimulating hormone; CESC cis rs1483890 0.723 rs13077078 chr3:69411402 C/A cg22125112 chr3:69402811 FRMD4B 0.39 5.24 0.31 3.3e-7 Resting heart rate; CESC cis rs858239 0.899 rs2268745 chr7:23317600 G/A cg23682824 chr7:23144976 KLHL7 0.43 5.54 0.32 7.21e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7551222 0.749 rs11240764 chr1:204569376 A/G cg20240347 chr1:204465584 NA -0.27 -5.52 -0.32 7.95e-8 Schizophrenia; CESC cis rs858239 0.600 rs9691762 chr7:23125922 G/C cg23682824 chr7:23144976 KLHL7 0.55 7.64 0.43 3.9e-13 Cerebrospinal fluid biomarker levels; CESC cis rs909002 0.925 rs10798882 chr1:32108547 C/G cg13919466 chr1:32135498 COL16A1 0.49 8.77 0.47 2.18e-16 Intelligence (multi-trait analysis); CESC cis rs3540 0.920 rs7182658 chr15:91019248 A/T cg10434728 chr15:90938212 IQGAP1 0.32 5.49 0.32 9.21e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg00166722 chr3:10149974 C3orf24 0.52 6.48 0.37 4.4e-10 Alzheimer's disease; CESC cis rs2617583 0.967 rs2617595 chr5:1448246 C/T cg07151155 chr5:1473589 LPCAT1 -0.37 -5.66 -0.33 3.94e-8 Breast cancer; CESC cis rs7208859 0.623 rs11657369 chr17:29136468 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1729951 0.545 rs1097288 chr3:136693721 C/T cg03617693 chr3:136751559 NA 0.39 5.38 0.31 1.68e-7 Neuroticism; CESC cis rs11583043 0.958 rs11583674 chr1:101396560 C/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 5.17 0.3 4.71e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs7208859 0.615 rs216462 chr17:28895897 T/C cg19761014 chr17:28927070 LRRC37B2 -0.77 -5.76 -0.33 2.32e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6991838 0.584 rs4637885 chr8:66497084 T/C cg13398993 chr8:66546079 ARMC1 -0.48 -5.74 -0.33 2.62e-8 Intelligence (multi-trait analysis); CESC cis rs1950626 0.750 rs34144313 chr14:101431216 C/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.83 11.29 0.57 2.14e-24 Pelvic organ prolapse (moderate/severe); CESC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg12463550 chr7:65579703 CRCP -0.49 -6.21 -0.36 2.06e-9 Aortic root size; CESC cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg20503657 chr10:835505 NA 1.09 9.95 0.52 4.95e-20 Eosinophil percentage of granulocytes; CESC cis rs9457247 0.515 rs2757039 chr6:167370353 G/T cg25258033 chr6:167368657 RNASET2 -0.38 -5.55 -0.32 7.08e-8 Crohn's disease; CESC cis rs10089 1.000 rs4835941 chr5:127430905 C/T cg19767477 chr5:127420684 SLC12A2 -0.43 -5.88 -0.34 1.23e-8 Ileal carcinoids; CESC cis rs5769765 1.000 rs2295409 chr22:50261060 G/C cg26441486 chr22:50317300 CRELD2 -0.39 -5.4 -0.32 1.45e-7 Schizophrenia; CESC cis rs7613875 0.543 rs34034116 chr3:49959156 C/A cg24308560 chr3:49941425 MST1R -0.58 -8.38 -0.46 3.04e-15 Body mass index; CESC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg07677032 chr17:61819896 STRADA 0.46 6.21 0.36 2.06e-9 Prudent dietary pattern; CESC cis rs67311347 0.866 rs2371183 chr3:40334247 C/T cg09455208 chr3:40491958 NA -0.39 -6.55 -0.37 2.9e-10 Renal cell carcinoma; CESC cis rs7666738 0.544 rs35160902 chr4:98974690 A/T cg17366294 chr4:99064904 C4orf37 0.58 8.21 0.45 9.69e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6912958 1.000 rs2207144 chr6:88150816 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -5.32 -0.31 2.19e-7 Monocyte percentage of white cells; CESC cis rs738322 0.805 rs2016755 chr22:38539604 A/G cg17652424 chr22:38574118 PLA2G6 -0.29 -5.19 -0.3 4.14e-7 Cutaneous nevi; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04464357 chr3:52931527 TMEM110 0.52 6.09 0.35 3.96e-9 Gut microbiome composition (summer); CESC cis rs11098499 0.789 rs10212719 chr4:120254437 T/C cg09307838 chr4:120376055 NA 0.8 10.84 0.55 6.73e-23 Corneal astigmatism; CESC cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg25019033 chr10:957182 NA -0.66 -8.28 -0.45 6.05e-15 Eosinophil percentage of granulocytes; CESC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg02574844 chr11:5959923 NA 0.53 7.77 0.43 1.78e-13 DNA methylation (variation); CESC cis rs6930083 0.605 rs3829964 chr6:36644498 T/C cg08179530 chr6:36648295 CDKN1A 0.79 12.27 0.6 1.05e-27 Coronary artery disease; CESC cis rs4253772 0.591 rs6008545 chr22:46686375 C/T cg24881330 chr22:46731750 TRMU 0.83 8.38 0.46 3.1e-15 LDL cholesterol;Cholesterol, total; CESC trans rs8180040 0.966 rs34634681 chr3:47579102 G/A cg09317728 chr14:101699148 NA 0.36 6.02 0.35 5.66e-9 Colorectal cancer; CESC cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg19077165 chr18:44547161 KATNAL2 0.52 7.41 0.41 1.74e-12 Personality dimensions; CESC cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg02375832 chr11:62437615 C11orf48 -0.37 -5.38 -0.31 1.66e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg02463440 chr8:22132932 PIWIL2 0.38 5.76 0.33 2.38e-8 Hypertriglyceridemia; CESC cis rs7107174 1.000 rs4945274 chr11:78109260 G/A cg02023728 chr11:77925099 USP35 0.37 5.33 0.31 2.12e-7 Testicular germ cell tumor; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg02667081 chr16:71880439 ATXN1L -0.46 -6.06 -0.35 4.78e-9 Height; CESC cis rs7100689 0.577 rs10788545 chr10:82034675 A/G cg00277334 chr10:82204260 NA -0.53 -6.64 -0.38 1.82e-10 Post bronchodilator FEV1; CESC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg18876405 chr7:65276391 NA 0.5 6.68 0.38 1.43e-10 Aortic root size; CESC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.53 -6.58 -0.37 2.55e-10 Prudent dietary pattern; CESC cis rs1577917 1.000 rs35419329 chr6:86702291 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -5.97 -0.34 7.47e-9 Response to antipsychotic treatment; CESC cis rs818427 0.826 rs439456 chr5:112205207 G/C cg07820702 chr5:112228657 REEP5 0.43 5.36 0.31 1.85e-7 Total body bone mineral density; CESC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.71 0.38 1.15e-10 Bipolar disorder; CESC cis rs8060686 0.641 rs76053508 chr16:68243054 A/T cg26727032 chr16:67993705 SLC12A4 -0.53 -5.95 -0.34 8.65e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs727563 0.608 rs2076200 chr22:41985956 G/T cg06634786 chr22:41940651 POLR3H -0.67 -6.46 -0.37 4.85e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs34375054 0.624 rs12826658 chr12:125680237 A/G cg25124228 chr12:125621409 AACS -0.48 -5.48 -0.32 9.88e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs3733585 0.699 rs1122142 chr4:9947548 G/C cg00071950 chr4:10020882 SLC2A9 -0.74 -12.17 -0.6 2.36e-27 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13040088 1.000 rs910831 chr20:61558775 T/C cg23096297 chr20:61557774 DIDO1 0.97 10.48 0.54 9.68e-22 Menopause (age at onset); CESC cis rs870825 0.616 rs6552801 chr4:185620623 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12168153 chr19:55770892 SAPS1 -0.64 -7.54 -0.42 7.44e-13 Gut microbiome composition (summer); CESC trans rs10411161 0.702 rs8113685 chr19:52383890 C/T cg22319618 chr22:45562946 NUP50 -0.7 -6.78 -0.38 7.84e-11 Breast cancer; CESC cis rs425277 1.000 rs262672 chr1:2080813 G/T cg16545954 chr1:2118288 C1orf86 0.33 5.6 0.33 5.35e-8 Height; CESC cis rs7188697 0.922 rs2243463 chr16:58571189 T/C cg02549819 chr16:58548995 SETD6 -0.42 -5.3 -0.31 2.46e-7 QT interval; CESC cis rs58804349 0.685 rs11239855 chr10:43483879 A/G cg08461752 chr10:43522343 NA 0.58 5.2 0.3 3.96e-7 Pediatric bone mineral content (radius); CESC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg08859206 chr1:53392774 SCP2 -0.71 -9.87 -0.52 8.91e-20 Monocyte count; CESC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg22535103 chr8:58192502 C8orf71 -0.84 -9.44 -0.5 2.04e-18 Developmental language disorder (linguistic errors); CESC cis rs9291683 0.595 rs13150928 chr4:10052961 G/T cg00071950 chr4:10020882 SLC2A9 0.83 14.82 0.67 1.32e-36 Bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18409845 chr10:94050143 CPEB3;MARCH5 0.42 6.02 0.35 5.77e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.83 11.75 0.59 6.1e-26 Alzheimer's disease; CESC cis rs1348850 0.872 rs10165785 chr2:178293295 C/T cg22681709 chr2:178499509 PDE11A -0.44 -6.53 -0.37 3.34e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg25072359 chr17:41440525 NA 0.46 6.2 0.36 2.18e-9 Menopause (age at onset); CESC cis rs832540 0.966 rs252925 chr5:56203773 G/A cg14703610 chr5:56206110 C5orf35 0.54 7.11 0.4 1.1e-11 Coronary artery disease; CESC cis rs3733585 0.578 rs6837224 chr4:9955255 G/T cg11266682 chr4:10021025 SLC2A9 -0.57 -10.92 -0.56 3.75e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1322639 0.574 rs9364360 chr6:169580174 G/A cg04662567 chr6:169592167 NA -0.49 -5.11 -0.3 6.06e-7 Pulse pressure; CESC trans rs11098499 0.779 rs7699346 chr4:120310542 C/T cg25214090 chr10:38739885 LOC399744 0.67 9.03 0.49 3.54e-17 Corneal astigmatism; CESC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg17372223 chr3:52568218 NT5DC2 0.4 5.93 0.34 9.47e-9 Electroencephalogram traits; CESC cis rs74181299 0.964 rs2540948 chr2:65284623 T/C cg05010058 chr2:65284262 CEP68 0.34 5.85 0.34 1.45e-8 Pulse pressure; CESC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg04267008 chr7:1944627 MAD1L1 -0.62 -7.68 -0.43 3.12e-13 Bipolar disorder and schizophrenia; CESC cis rs2276314 1.000 rs4799835 chr18:33571268 G/A cg19628046 chr18:33552617 C18orf21 0.57 6.02 0.35 5.73e-9 Endometriosis;Drug-induced torsades de pointes; CESC cis rs6921919 0.583 rs2041230 chr6:28365515 A/G cg00651523 chr6:28411279 ZSCAN23 -0.32 -5.08 -0.3 7.26e-7 Autism spectrum disorder or schizophrenia; CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg16103275 chr6:290800 DUSP22 0.44 6.06 0.35 4.67e-9 Menopause (age at onset); CESC trans rs11098499 0.954 rs2892848 chr4:120381341 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.86 0.52 9.48e-20 Corneal astigmatism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08898192 chr17:8042067 NA 0.47 6.31 0.36 1.16e-9 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00352560 chr1:45106266 RNF220 -0.54 -6.09 -0.35 3.99e-9 Gut microbiome composition (summer); CESC cis rs3126085 0.935 rs2184950 chr1:152272776 T/C cg03465714 chr1:152285911 FLG 0.47 5.59 0.32 5.67e-8 Atopic dermatitis; CESC cis rs684232 0.602 rs34167561 chr17:509268 G/A cg12384639 chr17:618140 VPS53 0.43 5.52 0.32 8.04e-8 Prostate cancer; CESC trans rs6934970 0.860 rs1455910 chr6:112995882 G/T cg05146922 chr2:10634174 NA -0.38 -6.04 -0.35 5.19e-9 Bipolar disorder (body mass index interaction); CESC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg05313129 chr8:58192883 C8orf71 -0.48 -5.18 -0.3 4.41e-7 Developmental language disorder (linguistic errors); CESC cis rs11958404 0.789 rs72818150 chr5:157484121 A/G cg05962755 chr5:157440814 NA 0.62 7.24 0.41 4.78e-12 IgG glycosylation; CESC cis rs8031584 1.000 rs35811129 chr15:31241346 G/A cg14829155 chr15:31115871 NA -0.77 -9.84 -0.52 1.13e-19 Huntington's disease progression; CESC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg27572855 chr1:25598939 RHD -0.43 -7.03 -0.4 1.72e-11 Erythrocyte sedimentation rate; CESC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg18099408 chr3:52552593 STAB1 0.3 5.15 0.3 5.02e-7 Bipolar disorder; CESC cis rs7647973 1.000 rs4241407 chr3:49600319 C/T cg07636037 chr3:49044803 WDR6 0.71 10.36 0.54 2.45e-21 Menarche (age at onset); CESC cis rs754466 0.606 rs11002310 chr10:79596030 A/C cg17075019 chr10:79541650 NA -0.88 -14.1 -0.65 4.71e-34 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2797160 0.651 rs1268067 chr6:126036621 T/C cg05901451 chr6:126070800 HEY2 0.5 7.3 0.41 3.35e-12 Endometrial cancer; CESC trans rs57221529 0.766 rs72706606 chr5:558609 T/C cg25482853 chr8:67687455 SGK3 1.11 11.94 0.59 1.39e-26 Lung disease severity in cystic fibrosis; CESC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg18252515 chr7:66147081 NA 0.47 6.17 0.35 2.57e-9 Aortic root size; CESC cis rs7089973 0.604 rs11196947 chr10:116601372 G/A cg23260525 chr10:116636907 FAM160B1 0.4 7.2 0.4 6.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2066819 1.000 rs871130 chr12:56648777 A/G cg26714650 chr12:56694279 CS 1.42 10.05 0.53 2.39e-20 Psoriasis vulgaris; CESC cis rs4919687 0.550 rs11191371 chr10:104459897 G/C cg04362960 chr10:104952993 NT5C2 0.44 5.16 0.3 4.76e-7 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20390741 chr1:87597574 LOC339524 0.62 7.45 0.42 1.29e-12 Gut microbiome composition (summer); CESC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg26314531 chr2:26401878 FAM59B -0.84 -9.75 -0.51 2.13e-19 Gut microbiome composition (summer); CESC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg07952391 chr2:88470173 THNSL2 0.62 6.05 0.35 4.86e-9 Plasma clusterin levels; CESC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg22823121 chr1:150693482 HORMAD1 0.45 6.26 0.36 1.57e-9 Melanoma; CESC cis rs2832191 0.692 rs2776240 chr21:30310639 C/T cg08807101 chr21:30365312 RNF160 0.88 13.66 0.64 1.55e-32 Dental caries; CESC cis rs4604732 0.588 rs7549495 chr1:247627806 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.53 6.57 0.37 2.7e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg26597838 chr10:835615 NA 0.87 9.15 0.49 1.58e-17 Eosinophil percentage of granulocytes; CESC cis rs7193541 0.684 rs8062783 chr16:74691264 C/T cg01733217 chr16:74700730 RFWD3 -1.05 -20.08 -0.78 3.85e-55 Multiple myeloma; CESC cis rs9859260 0.744 rs406271 chr3:195776976 T/C cg12923728 chr3:195709715 SDHAP1 0.54 6.98 0.39 2.38e-11 Mean corpuscular volume; CESC cis rs2011503 0.882 rs4808958 chr19:19571752 G/A cg11584989 chr19:19387371 SF4 0.67 7.61 0.42 4.87e-13 Bipolar disorder; CESC cis rs66573146 0.831 rs11546450 chr4:7032180 G/A cg00086871 chr4:6988644 TBC1D14 0.97 5.96 0.34 7.99e-9 Granulocyte percentage of myeloid white cells; CESC cis rs6460942 0.591 rs62448727 chr7:12332362 G/C cg20607287 chr7:12443886 VWDE -0.63 -6.83 -0.39 5.83e-11 Coronary artery disease; CESC cis rs7772486 0.846 rs9376976 chr6:146355605 T/C cg23711669 chr6:146136114 FBXO30 0.85 12.46 0.61 2.27e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs193541 0.632 rs2407402 chr5:122107105 G/C cg19412675 chr5:122181750 SNX24 0.45 5.27 0.31 2.81e-7 Glucose homeostasis traits; CESC cis rs9635726 0.638 rs2952155 chr17:37861718 T/C cg07936489 chr17:37558343 FBXL20 -0.66 -7.08 -0.4 1.3e-11 Primary biliary cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15232214 chr8:123964031 ZHX2 -0.55 -6.5 -0.37 3.91e-10 Gut microbiome composition (summer); CESC cis rs56036086 1.000 rs73187250 chr22:50634552 G/A cg16473166 chr22:50639996 SELO 0.65 5.11 0.3 6.25e-7 Platelet count;Plateletcrit; CESC cis rs2404602 0.692 rs58361452 chr15:76973372 T/C cg26408565 chr15:76604113 ETFA -0.39 -5.72 -0.33 2.94e-8 Blood metabolite levels; CESC cis rs56399783 0.901 rs6967664 chr7:2816384 A/G cg19731401 chr7:2775893 GNA12 0.64 5.75 0.33 2.49e-8 Childhood ear infection; CESC cis rs6782228 1.000 rs35604103 chr3:128334852 C/T cg15607142 chr3:128420513 NA -0.37 -5.15 -0.3 5.19e-7 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; CESC cis rs782590 0.582 rs2627767 chr2:55926815 A/T cg18811423 chr2:55921094 PNPT1 0.76 12.23 0.6 1.44e-27 Metabolic syndrome; CESC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.62 -8.04 -0.44 2.94e-14 Tonsillectomy; CESC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg08392591 chr16:89556376 ANKRD11 0.62 8.43 0.46 2.25e-15 Multiple myeloma (IgH translocation); CESC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg26335602 chr6:28129616 ZNF389 0.54 7.18 0.4 6.95e-12 Depression; CESC cis rs9916302 0.904 rs11078898 chr17:37536480 A/G cg00129232 chr17:37814104 STARD3 0.57 7.41 0.41 1.7e-12 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14311538 chr9:139348775 SEC16A -0.56 -6.09 -0.35 3.93e-9 Gut microbiome composition (summer); CESC trans rs11264799 0.765 rs12144103 chr1:157620499 A/G cg22691776 chr3:15032403 NR2C2 0.34 6.29 0.36 1.29e-9 IgA nephropathy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04841405 chr16:1501118 CLCN7 0.45 6.21 0.36 2.07e-9 Fibrinogen levels; CESC cis rs4604732 0.631 rs56704806 chr1:247626148 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2839186 0.900 rs2839200 chr21:47709095 C/T cg10351095 chr21:47802916 PCNT -0.51 -6.89 -0.39 4.11e-11 Testicular germ cell tumor; CESC cis rs9913156 0.696 rs72835620 chr17:4558128 G/A cg19197139 chr17:4613644 ARRB2 0.91 10.33 0.54 3.1e-21 Lymphocyte counts; CESC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.71 -0.33 3.04e-8 Lung cancer; CESC cis rs1465370 0.682 rs2239604 chr7:130021331 C/T cg04743876 chr7:130013617 NA 0.3 5.59 0.32 5.57e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs11711311 0.955 rs9813630 chr3:113377361 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.45 0.37 5.36e-10 IgG glycosylation; CESC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.25 -0.31 3.16e-7 Lung cancer; CESC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg24578937 chr1:2090814 PRKCZ -0.33 -5.77 -0.33 2.21e-8 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14490552 chr8:101965602 YWHAZ -0.5 -6.38 -0.36 8.03e-10 Fibrinogen levels; CESC trans rs61931739 0.500 rs7977186 chr12:34431486 C/G cg13010199 chr12:38710504 ALG10B 0.49 6.3 0.36 1.24e-9 Morning vs. evening chronotype; CESC cis rs7542091 0.704 rs7537294 chr1:210043777 A/G cg09509183 chr1:209979624 IRF6 0.4 5.78 0.33 2.12e-8 Monobrow; CESC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg16545954 chr1:2118288 C1orf86 -0.31 -5.97 -0.34 7.74e-9 Height; CESC cis rs854765 0.647 rs6502637 chr17:17986098 A/G cg04398451 chr17:18023971 MYO15A -0.76 -11.23 -0.57 3.42e-24 Total body bone mineral density; CESC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg05863683 chr7:1912471 MAD1L1 0.42 6.09 0.35 4.06e-9 Bipolar disorder and schizophrenia; CESC cis rs28829049 0.597 rs12740975 chr1:19437923 G/A cg13387374 chr1:19411106 UBR4 0.41 5.09 0.3 6.7e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs5758659 0.935 rs134879 chr22:42664201 A/C cg05082376 chr22:42548792 NA -0.38 -5.74 -0.33 2.54e-8 Cognitive function; CESC cis rs11792861 0.926 rs11788904 chr9:111865052 T/C cg05043794 chr9:111880884 C9orf5 -0.42 -6.93 -0.39 3.22e-11 Menarche (age at onset); CESC cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg00677455 chr12:58241039 CTDSP2 0.51 6.61 0.38 2.15e-10 Multiple sclerosis; CESC cis rs2742234 0.541 rs7073849 chr10:43740474 G/C cg15436174 chr10:43711423 RASGEF1A 0.46 5.3 0.31 2.44e-7 Hirschsprung disease; CESC cis rs8002861 0.846 rs12428314 chr13:44476011 C/T cg19180546 chr13:44453867 C13orf31;CCDC122 -0.45 -5.79 -0.34 1.94e-8 Leprosy; CESC cis rs7772486 0.774 rs2247571 chr6:146219533 T/A cg05347473 chr6:146136440 FBXO30 0.42 5.85 0.34 1.45e-8 Lobe attachment (rater-scored or self-reported); CESC trans rs1728785 1.000 rs1170445 chr16:68573064 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.44 0.42 1.41e-12 Ulcerative colitis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06725705 chr16:9058264 USP7 -0.48 -6.21 -0.36 1.99e-9 Ulcerative colitis; CESC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs11190604 1.000 rs2495752 chr10:102326115 T/C cg07080220 chr10:102295463 HIF1AN 0.63 5.98 0.34 7.11e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg08968635 chr6:28129556 ZNF389 0.41 5.53 0.32 7.61e-8 Depression; CESC cis rs2880765 0.835 rs7162502 chr15:86044473 G/T cg19183879 chr15:85880815 NA -0.26 -5.29 -0.31 2.52e-7 Coronary artery disease; CESC cis rs6460942 0.915 rs62448598 chr7:12453762 T/C cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs8072100 0.807 rs2175290 chr17:45479917 C/A cg25173405 chr17:45401733 C17orf57 -0.42 -5.54 -0.32 7.43e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg08859206 chr1:53392774 SCP2 -0.6 -8.05 -0.44 2.89e-14 Monocyte count; CESC cis rs2299587 0.560 rs391299 chr8:17778922 T/C cg08627089 chr8:17753878 FGL1 -0.41 -5.37 -0.31 1.76e-7 Economic and political preferences; CESC cis rs10129255 0.500 rs4774008 chr14:107137290 A/T cg07958169 chr14:107095056 NA -0.57 -9.05 -0.49 3.15e-17 Kawasaki disease; CESC cis rs412050 0.547 rs61763401 chr22:22139847 C/T cg17089214 chr22:22089827 YPEL1 0.68 5.54 0.32 7.29e-8 Attention deficit hyperactivity disorder; CESC trans rs1814175 0.645 rs11040671 chr11:49958776 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.31 -0.36 1.18e-9 Life satisfaction; CESC cis rs4722166 0.604 rs2390715 chr7:22783878 A/C cg26061582 chr7:22766209 IL6 0.51 5.5 0.32 9.05e-8 Lung cancer; CESC cis rs9487051 0.676 rs6903107 chr6:109597711 A/G cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC cis rs57506017 0.585 rs13237715 chr7:12269575 G/C cg23422036 chr7:12250390 TMEM106B 0.38 5.15 0.3 5.16e-7 Neuroticism; CESC cis rs11711311 0.747 rs2895415 chr3:113345565 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.56 7.44 0.42 1.37e-12 IgG glycosylation; CESC cis rs12142240 0.698 rs41294458 chr1:46810304 T/C cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs9583531 0.629 rs7991766 chr13:111380684 A/G cg15841412 chr13:111365552 ING1 0.44 5.52 0.32 8.18e-8 Coronary artery disease; CESC cis rs6088590 1.000 rs6119535 chr20:33442138 A/C cg08999081 chr20:33150536 PIGU 0.48 7.12 0.4 9.85e-12 Coronary artery disease; CESC cis rs7408868 1.000 rs757475 chr19:15273749 C/T cg14696996 chr19:15285081 NOTCH3 1.11 11.47 0.58 5.57e-25 Pulse pressure; CESC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg01171360 chr6:293285 DUSP22 -0.68 -9.07 -0.49 2.81e-17 Menopause (age at onset); CESC cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.71 9.04 0.49 3.3e-17 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14435640 chr8:41436176 AGPAT6 -0.55 -6.11 -0.35 3.59e-9 Gut microbiome composition (summer); CESC cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg12386194 chr3:101231763 SENP7 0.57 6.55 0.37 3e-10 Colonoscopy-negative controls vs population controls; CESC cis rs2249694 0.960 rs4556495 chr10:135422209 C/T cg20169779 chr10:135381914 SYCE1 -0.39 -5.64 -0.33 4.39e-8 Obesity-related traits; CESC cis rs963731 0.649 rs297125 chr2:39314969 G/A cg04010122 chr2:39346883 SOS1 -0.74 -5.39 -0.31 1.54e-7 Corticobasal degeneration; CESC cis rs7000551 0.642 rs2122880 chr8:22375042 C/A cg12081754 chr8:22256438 SLC39A14 0.38 5.08 0.3 7.12e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs7945705 0.869 rs4909952 chr11:8963946 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.36 5.93 0.34 9.43e-9 Hemoglobin concentration; CESC cis rs4727027 0.868 rs10952799 chr7:148840772 C/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.97 -0.39 2.57e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4566357 0.615 rs10198214 chr2:227913314 A/C cg05526886 chr2:227700861 RHBDD1 -0.46 -6.15 -0.35 2.88e-9 Coronary artery disease; CESC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg22903471 chr2:27725779 GCKR -0.59 -8.52 -0.46 1.23e-15 Total body bone mineral density; CESC cis rs950169 0.840 rs4842854 chr15:84942339 T/G cg17507749 chr15:85114479 UBE2QP1 0.59 6.52 0.37 3.46e-10 Schizophrenia; CESC cis rs631288 0.793 rs10900331 chr1:146733128 C/G cg25205988 chr1:146714368 CHD1L 1.04 8.67 0.47 4.54e-16 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg04944784 chr2:26401820 FAM59B 0.81 7.96 0.44 5.13e-14 Gut microbiome composition (summer); CESC cis rs7301826 0.651 rs4759517 chr12:131283698 G/A cg11011512 chr12:131303247 STX2 0.47 5.77 0.33 2.26e-8 Plasma plasminogen activator levels; CESC trans rs1814175 0.645 rs1608632 chr11:49967148 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11072298 chr12:113772666 SLC24A6 0.58 6.54 0.37 3.16e-10 Gut microbiome composition (summer); CESC cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs17685 0.784 rs1637043 chr7:75699099 G/A cg19862616 chr7:65841803 NCRNA00174 0.87 12.71 0.62 3.24e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs17376456 0.825 rs10038831 chr5:93124115 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.26 0.31 3.01e-7 Diabetic retinopathy; CESC cis rs6691722 0.503 rs1142057 chr1:24706292 C/T cg18323236 chr1:24743029 NIPAL3 -0.38 -5.77 -0.33 2.25e-8 Response to interferon beta in multiple sclerosis; CESC cis rs780096 1.000 rs780096 chr2:27741072 C/G cg22903471 chr2:27725779 GCKR -0.38 -5.2 -0.3 3.98e-7 Total body bone mineral density; CESC cis rs3820068 0.581 rs12385690 chr1:15932932 A/T cg17385448 chr1:15911702 AGMAT 0.44 7.46 0.42 1.27e-12 Systolic blood pressure; CESC cis rs28489187 0.683 rs12047422 chr1:85848830 T/G cg16011679 chr1:85725395 C1orf52 0.53 6.17 0.35 2.49e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs6866344 0.570 rs1071882 chr5:178136040 C/T cg10224037 chr5:178157518 ZNF354A 0.7 8.48 0.46 1.65e-15 Neutrophil percentage of white cells; CESC cis rs6669072 0.739 rs3843305 chr1:91243376 G/A cg08895590 chr1:91227319 NA -0.36 -6.15 -0.35 2.8e-9 Cognitive function; CESC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg25405998 chr7:65216604 CCT6P1 0.45 5.06 0.3 7.71e-7 Aortic root size; CESC cis rs7044106 0.762 rs1411158 chr9:123464804 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.98 0.34 7.3e-9 Hip circumference adjusted for BMI; CESC cis rs13082711 0.595 rs13075389 chr3:27339586 C/T cg02860705 chr3:27208620 NA 0.76 9.16 0.49 1.46e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg22968622 chr17:43663579 NA 0.79 10.74 0.55 1.39e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg09509183 chr1:209979624 IRF6 0.51 6.27 0.36 1.44e-9 Cleft lip with or without cleft palate; CESC cis rs10779751 0.770 rs11585553 chr1:11233814 G/A cg08854313 chr1:11322531 MTOR -0.74 -8.37 -0.46 3.36e-15 Body mass index; CESC trans rs3808502 0.525 rs13280813 chr8:11425105 G/T cg15556689 chr8:8085844 FLJ10661 -0.55 -6.44 -0.37 5.68e-10 Neuroticism; CESC cis rs716804 0.592 rs10770106 chr11:10312077 A/C cg01453529 chr11:10209919 SBF2 -0.69 -6.1 -0.35 3.68e-9 Neuroticism; CESC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg00484396 chr16:3507460 NAT15 0.44 7.27 0.41 4.08e-12 Tuberculosis; CESC cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg16339924 chr4:17578868 LAP3 0.73 9.53 0.51 1.03e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07080049 chr9:96214194 FAM120A;FAM120AOS 0.51 6.46 0.37 5.13e-10 Gut microbiota (bacterial taxa); CESC cis rs3820068 0.581 rs67806552 chr1:15927138 T/C cg13390004 chr1:15929781 NA 0.34 5.45 0.32 1.13e-7 Systolic blood pressure; CESC cis rs2953174 0.786 rs2953177 chr2:241516616 A/G cg07929629 chr2:241523174 NA 0.54 5.91 0.34 1.03e-8 Bipolar disorder; CESC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg18538332 chr22:24372958 LOC391322 -0.61 -7.38 -0.41 2.02e-12 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs79349575 0.811 rs12601072 chr17:46997998 T/C cg16584676 chr17:46985605 UBE2Z 0.54 6.7 0.38 1.24e-10 Type 2 diabetes; CESC cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg18527119 chr7:66119851 NA -0.47 -5.07 -0.3 7.42e-7 Aortic root size; CESC cis rs35306767 0.953 rs12762973 chr10:960761 C/G cg10556349 chr10:835070 NA 0.59 5.95 0.34 8.58e-9 Eosinophil percentage of granulocytes; CESC cis rs2050392 0.630 rs303426 chr10:30740379 A/G cg25182066 chr10:30743637 MAP3K8 0.48 6.88 0.39 4.34e-11 Inflammatory bowel disease; CESC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.5 -0.32 9.09e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1065656 0.571 rs12149777 chr16:1834724 A/G cg08610935 chr16:1836813 NUBP2 -0.47 -6.58 -0.37 2.47e-10 Insulin-like growth factors; CESC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.71 9.31 0.5 5.06e-18 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01820765 chr16:85241897 NA 0.43 6.02 0.35 5.82e-9 Fibrinogen levels; CESC cis rs10465746 0.725 rs2024591 chr1:84329235 C/T cg10977910 chr1:84465055 TTLL7 0.54 7.39 0.41 1.96e-12 Obesity-related traits; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg04574282 chr14:89315467 TTC8 0.37 6.01 0.35 5.98e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs870825 0.616 rs2130393 chr4:185642335 T/C cg04058563 chr4:185651563 MLF1IP 0.65 7.16 0.4 8e-12 Blood protein levels; CESC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg10018233 chr7:150070692 REPIN1 0.44 6.42 0.37 6.3e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs6582630 0.519 rs8189618 chr12:38276281 A/C cg13010199 chr12:38710504 ALG10B 0.48 6.04 0.35 5.23e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs4566357 0.615 rs4350744 chr2:227918146 A/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.15 -0.4 8.26e-12 Coronary artery disease; CESC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg00101154 chr16:420108 MRPL28 -0.45 -5.18 -0.3 4.46e-7 Bone mineral density (spine);Bone mineral density; CESC cis rs4481887 0.861 rs4486480 chr1:248449714 C/T cg00666640 chr1:248458726 OR2T12 0.41 6.68 0.38 1.37e-10 Common traits (Other); CESC cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg20573242 chr4:122745356 CCNA2 0.66 8.14 0.45 1.6e-14 Type 2 diabetes; CESC cis rs3857067 0.772 rs4438731 chr4:95091384 A/G cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.1 -0.49 2.18e-17 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12738349 chr22:24236284 MIF 0.58 7.09 0.4 1.19e-11 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg12463550 chr7:65579703 CRCP 0.56 6.76 0.38 8.75e-11 Aortic root size; CESC cis rs9325144 0.555 rs10748433 chr12:38696352 C/G cg26384229 chr12:38710491 ALG10B 0.58 8.47 0.46 1.67e-15 Morning vs. evening chronotype; CESC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.7 0.38 1.25e-10 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26450010 chr19:17412054 ABHD8 0.48 6.8 0.39 6.8e-11 Fibrinogen levels; CESC cis rs8044868 0.530 rs9928157 chr16:72117073 T/C cg16558253 chr16:72132732 DHX38 -0.39 -6.08 -0.35 4.27e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg00166722 chr3:10149974 C3orf24 0.46 5.88 0.34 1.21e-8 Alzheimer's disease; CESC cis rs4588572 0.642 rs7722126 chr5:77645784 T/C cg11547950 chr5:77652471 NA -0.43 -6.23 -0.36 1.85e-9 Triglycerides; CESC cis rs568617 0.953 rs658524 chr11:65647260 A/G cg19792802 chr11:65647270 CTSW -0.35 -5.31 -0.31 2.33e-7 Crohn's disease; CESC trans rs6089829 0.962 rs7273930 chr20:61666017 G/A cg23505145 chr19:12996616 KLF1 0.53 6.86 0.39 4.74e-11 Prostate cancer (SNP x SNP interaction); CESC trans rs3942852 0.622 rs6485806 chr11:48102806 A/G cg03929089 chr4:120376271 NA 0.52 6.0 0.35 6.41e-9 Acute lymphoblastic leukemia (childhood); CESC trans rs801193 1.000 rs2707856 chr7:66211010 A/T cg26939375 chr7:64535504 NA 0.66 9.05 0.49 3.22e-17 Aortic root size; CESC cis rs11650494 0.803 rs117801358 chr17:47447950 C/A cg08112188 chr17:47440006 ZNF652 1.16 7.85 0.43 1.06e-13 Prostate cancer; CESC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg17221315 chr6:27791827 HIST1H4J 0.45 5.69 0.33 3.44e-8 Parkinson's disease; CESC cis rs7116495 0.609 rs79889241 chr11:71815585 T/C cg26138937 chr11:71823887 C11orf51 1.33 8.25 0.45 7.62e-15 Severe influenza A (H1N1) infection; CESC trans rs7615952 0.599 rs7631268 chr3:125755664 T/A cg07211511 chr3:129823064 LOC729375 -0.59 -6.52 -0.37 3.53e-10 Blood pressure (smoking interaction); CESC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg02931644 chr1:25747376 RHCE -0.4 -6.55 -0.37 3.02e-10 Erythrocyte sedimentation rate; CESC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 11.83 0.59 3.37e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4835473 0.864 rs57648439 chr4:144612672 G/A cg25736465 chr4:144833511 NA -0.36 -5.4 -0.31 1.52e-7 Immature fraction of reticulocytes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23268322 chr19:50762551 MYH14 0.49 6.6 0.38 2.23e-10 Fibrinogen levels; CESC cis rs10788972 1.000 rs10788972 chr1:54572243 C/A cg25741118 chr1:54482237 LDLRAD1 -0.24 -5.68 -0.33 3.58e-8 Parkinson disease and lewy body pathology; CESC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg12463550 chr7:65579703 CRCP 0.57 7.06 0.4 1.5e-11 Aortic root size; CESC cis rs2637266 0.538 rs4379767 chr10:78472596 G/A cg18941641 chr10:78392320 NA -0.33 -5.29 -0.31 2.58e-7 Pulmonary function; CESC cis rs4654899 0.965 rs7512116 chr1:21501095 C/A cg05370193 chr1:21551575 ECE1 0.41 6.22 0.36 1.96e-9 Superior frontal gyrus grey matter volume; CESC cis rs644799 1.000 rs563653 chr11:95561488 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.76 0.38 8.51e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs5769765 0.908 rs4074304 chr22:50309446 G/A cg09872104 chr7:134855509 C7orf49 -0.55 -6.27 -0.36 1.47e-9 Schizophrenia; CESC cis rs55788414 0.932 rs12102728 chr16:81181436 C/T cg06400318 chr16:81190750 PKD1L2 -0.53 -6.56 -0.37 2.8e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg26441486 chr22:50317300 CRELD2 0.42 5.21 0.3 3.84e-7 Schizophrenia; CESC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg21790657 chr18:77675478 PQLC1 -0.49 -6.31 -0.36 1.17e-9 Tetralogy of Fallot; CESC cis rs7772486 0.622 rs1292333 chr6:145982344 C/T cg23711669 chr6:146136114 FBXO30 -0.91 -13.76 -0.65 7.23e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs6500395 0.962 rs9936883 chr16:48676443 G/A cg04672837 chr16:48644449 N4BP1 0.51 6.31 0.36 1.16e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg07701084 chr6:150067640 NUP43 0.47 6.58 0.37 2.47e-10 Lung cancer; CESC trans rs5756813 1.000 rs5756813 chr22:38175477 A/C cg19894588 chr14:64061835 NA -0.48 -6.76 -0.38 8.96e-11 Optic cup area;Vertical cup-disc ratio; CESC cis rs61996546 0.622 rs11639008 chr15:26842107 C/G cg15066197 chr15:26874202 GABRB3 -0.34 -5.1 -0.3 6.63e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs7089973 0.604 rs765174 chr10:116601888 C/T cg25233709 chr10:116636983 FAM160B1 0.38 6.08 0.35 4.13e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs11098499 0.954 rs3733520 chr4:120423480 C/G cg09160332 chr4:120329925 NA -0.38 -5.14 -0.3 5.22e-7 Corneal astigmatism; CESC trans rs877282 0.786 rs11253392 chr10:788768 G/A cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs3204270 0.639 rs79193599 chr17:79651490 C/A cg26965718 chr17:79658957 HGS -0.77 -5.22 -0.31 3.54e-7 Dental caries; CESC cis rs9815354 1.000 rs3934103 chr3:41977214 C/T cg03022575 chr3:42003672 ULK4 -0.46 -5.37 -0.31 1.74e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg17911788 chr17:44343683 NA -0.44 -6.9 -0.39 3.79e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg08736216 chr1:53307985 ZYG11A 0.38 6.62 0.38 2e-10 Monocyte count; CESC cis rs7116495 1.000 rs6592455 chr11:71689541 C/T cg26138937 chr11:71823887 C11orf51 0.83 6.17 0.35 2.52e-9 Severe influenza A (H1N1) infection; CESC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg26335602 chr6:28129616 ZNF389 0.4 5.52 0.32 7.96e-8 Cardiac Troponin-T levels; CESC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.53 5.37 0.31 1.74e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.95 -15.09 -0.68 1.47e-37 Prudent dietary pattern; CESC cis rs1371867 0.846 rs1788189 chr8:101249762 G/T cg11906718 chr8:101322791 RNF19A -0.44 -5.53 -0.32 7.67e-8 Atrioventricular conduction; CESC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.02 11.56 0.58 2.78e-25 Gut microbiome composition (summer); CESC cis rs1950626 0.833 rs1951025 chr14:101406022 T/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.79 10.67 0.55 2.42e-22 Pelvic organ prolapse (moderate/severe); CESC cis rs80282103 0.618 rs2387299 chr10:1163427 A/G cg08668510 chr10:1095578 IDI1 0.72 5.84 0.34 1.55e-8 Glomerular filtration rate (creatinine); CESC cis rs6502050 0.764 rs7215277 chr17:80159283 C/A cg23985595 chr17:80112537 CCDC57 -0.39 -6.24 -0.36 1.76e-9 Life satisfaction; CESC cis rs9790314 0.871 rs336551 chr3:161109720 T/C cg03342759 chr3:160939853 NMD3 -0.48 -6.68 -0.38 1.37e-10 Morning vs. evening chronotype; CESC cis rs3105593 0.933 rs3131601 chr15:50876942 A/C cg08437265 chr15:50716283 USP8 0.41 5.26 0.31 2.92e-7 QT interval; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09302609 chr2:121010281 RALB -0.46 -6.13 -0.35 3.25e-9 Fibrinogen levels; CESC cis rs6582630 0.555 rs11613249 chr12:38519339 T/C cg13010199 chr12:38710504 ALG10B 0.49 6.43 0.37 6.06e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs12249377 0.519 rs10785972 chr10:92593800 C/T cg14313238 chr10:92632228 RPP30 0.42 5.09 0.3 6.8e-7 White matter microstructure (global fractional anisotropy); CESC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs10189230 0.967 rs13002861 chr2:222352859 T/G cg14652038 chr2:222343519 EPHA4 0.37 7.75 0.43 1.97e-13 Urate levels in lean individuals; CESC cis rs8114671 0.562 rs6088653 chr20:33520321 T/C cg24642439 chr20:33292090 TP53INP2 0.44 5.32 0.31 2.18e-7 Height; CESC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg25405998 chr7:65216604 CCT6P1 0.45 5.06 0.3 7.71e-7 Aortic root size; CESC cis rs8072100 0.676 rs9908049 chr17:45502096 G/C cg08085267 chr17:45401833 C17orf57 -0.52 -6.6 -0.38 2.28e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs8040855 0.627 rs2304418 chr15:85640983 T/C cg08123816 chr15:85640762 PDE8A -0.41 -6.16 -0.35 2.7e-9 Bulimia nervosa; CESC cis rs2625529 0.617 rs8557 chr15:72115733 T/C cg16672083 chr15:72433130 SENP8 -0.48 -7.06 -0.4 1.42e-11 Red blood cell count; CESC cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg21573476 chr21:45109991 RRP1B -0.42 -5.86 -0.34 1.4e-8 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26820922 chr2:32503023 YIPF4 -0.61 -7.54 -0.42 7.56e-13 Gut microbiome composition (summer); CESC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg07936489 chr17:37558343 FBXL20 0.8 11.69 0.58 9.64e-26 Glomerular filtration rate (creatinine); CESC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.42 6.86 0.39 4.72e-11 Personality dimensions; CESC cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg03676636 chr4:99064102 C4orf37 0.35 5.21 0.3 3.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7818345 0.967 rs4412390 chr8:19270143 A/T cg11303988 chr8:19266685 CSGALNACT1 -0.32 -5.69 -0.33 3.34e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs561341 0.825 rs2008368 chr17:30347397 T/C cg19193384 chr17:30244184 NA -0.71 -6.43 -0.37 6.05e-10 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg06873352 chr17:61820015 STRADA 0.71 12.15 0.6 2.65e-27 Prudent dietary pattern; CESC cis rs11676348 0.846 rs13009946 chr2:219007752 A/C cg00012203 chr2:219082015 ARPC2 -0.54 -7.03 -0.4 1.73e-11 Ulcerative colitis; CESC trans rs11098499 0.863 rs1010739 chr4:120463471 C/T cg25214090 chr10:38739885 LOC399744 0.61 8.15 0.45 1.41e-14 Corneal astigmatism; CESC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg05132306 chr1:1846340 CALML6 -0.31 -6.61 -0.38 2.16e-10 Body mass index; CESC cis rs75887402 1.000 rs78557471 chr5:122731890 C/T cg27033705 chr5:122759302 CEP120 0.81 5.54 0.32 7.3e-8 Breast cancer; CESC cis rs7726839 0.540 rs72707016 chr5:665148 A/G cg16447950 chr5:562315 NA -0.62 -6.54 -0.37 3.09e-10 Obesity-related traits; CESC cis rs644799 0.965 rs499076 chr11:95546341 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs77956314 0.901 rs80001826 chr12:117335652 G/C cg02017074 chr12:117425053 FBXW8 -0.54 -5.14 -0.3 5.44e-7 Subcortical brain region volumes;Hippocampal volume; CESC cis rs67478160 0.634 rs2368558 chr14:104230518 A/G cg01849466 chr14:104193079 ZFYVE21 -0.53 -7.73 -0.43 2.26e-13 Schizophrenia; CESC trans rs7178375 0.941 rs35497908 chr15:31224071 C/T cg04373760 chr16:53404718 NA 0.54 7.26 0.41 4.39e-12 Hypertriglyceridemia; CESC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs9300255 0.506 rs11057251 chr12:123791227 A/G cg05973401 chr12:123451056 ABCB9 -0.45 -5.7 -0.33 3.22e-8 Neutrophil percentage of white cells; CESC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg16325326 chr1:53192061 ZYG11B 0.9 15.48 0.69 6.2e-39 Monocyte count; CESC cis rs11030122 0.673 rs10767767 chr11:4003678 C/T cg18678763 chr11:4115507 RRM1 -0.42 -5.57 -0.32 6.34e-8 Mean platelet volume;Platelet distribution width; CESC trans rs1814175 0.647 rs10839394 chr11:49844747 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -20.57 -0.78 7.78e-57 Height; CESC cis rs116095464 0.558 rs7725227 chr5:233517 G/A cg20965017 chr5:231967 SDHA -0.45 -5.05 -0.3 8.18e-7 Breast cancer; CESC cis rs72781680 0.768 rs56339558 chr2:24125234 G/A cg08917208 chr2:24149416 ATAD2B 0.6 5.95 0.34 8.39e-9 Lymphocyte counts; CESC cis rs2072499 0.554 rs1052067 chr1:156206121 C/T cg24450063 chr1:156163899 SLC25A44 0.61 7.43 0.42 1.48e-12 Testicular germ cell tumor; CESC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg18876405 chr7:65276391 NA 0.5 6.97 0.39 2.45e-11 Aortic root size; CESC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg13206674 chr6:150067644 NUP43 0.42 5.81 0.34 1.76e-8 Lung cancer; CESC cis rs3806933 0.522 rs12521169 chr5:110448313 G/A cg04022379 chr5:110408740 TSLP 0.47 7.61 0.42 4.93e-13 Eosinophilic esophagitis; CESC cis rs17376456 0.809 rs10476602 chr5:93445255 T/C cg25358565 chr5:93447407 FAM172A 1.12 11.84 0.59 3.05e-26 Diabetic retinopathy; CESC cis rs1707322 0.638 rs9429095 chr1:46603348 A/C cg06784218 chr1:46089804 CCDC17 -0.33 -5.3 -0.31 2.48e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs4332037 0.539 rs11762636 chr7:2061111 C/A cg11693508 chr17:37793320 STARD3 0.66 6.63 0.38 1.84e-10 Bipolar disorder; CESC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg19592336 chr6:28129416 ZNF389 0.6 8.08 0.44 2.36e-14 Depression; CESC cis rs1448094 0.838 rs28509446 chr12:86312584 A/C cg02569458 chr12:86230093 RASSF9 0.36 5.12 0.3 6.01e-7 Major depressive disorder; CESC cis rs1371867 0.810 rs1692004 chr8:101247320 T/C cg11906718 chr8:101322791 RNF19A -0.48 -6.12 -0.35 3.36e-9 Atrioventricular conduction; CESC cis rs561341 1.000 rs497479 chr17:30328605 C/T cg19193384 chr17:30244184 NA -0.66 -6.37 -0.36 8.42e-10 Hip circumference adjusted for BMI; CESC cis rs59918340 0.728 rs10875467 chr8:142233396 A/C cg23750338 chr8:142222470 SLC45A4 -0.6 -9.29 -0.5 5.66e-18 Immature fraction of reticulocytes; CESC cis rs9309473 0.904 rs62149783 chr2:73821384 T/A cg20560298 chr2:73613845 ALMS1 -0.54 -6.85 -0.39 5.25e-11 Metabolite levels; CESC cis rs2797160 1.000 rs2797158 chr6:126009398 G/A cg05901451 chr6:126070800 HEY2 0.45 6.57 0.37 2.63e-10 Endometrial cancer; CESC cis rs36051895 0.623 rs7023639 chr9:5244058 A/C cg02405213 chr9:5042618 JAK2 -0.49 -6.03 -0.35 5.51e-9 Pediatric autoimmune diseases; CESC cis rs2929278 0.561 rs2927071 chr15:43919081 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.8 0.39 6.77e-11 Schizophrenia; CESC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg00990874 chr7:1149470 C7orf50 -0.46 -5.08 -0.3 7.21e-7 Bronchopulmonary dysplasia; CESC cis rs1620921 0.505 rs4708878 chr6:161203026 A/G cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs7762018 1.000 rs6923339 chr6:170128033 T/A cg13891659 chr6:170190454 C6orf122;C6orf208 0.56 5.6 0.33 5.38e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6088580 0.570 rs6058057 chr20:33065283 G/A cg24642439 chr20:33292090 TP53INP2 0.52 6.9 0.39 3.73e-11 Glomerular filtration rate (creatinine); CESC cis rs1707322 0.686 rs1547924 chr1:46085112 C/T cg06784218 chr1:46089804 CCDC17 0.42 7.37 0.41 2.19e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7216064 0.532 rs3890640 chr17:66053028 C/T cg07042672 chr17:66097459 LOC651250 0.67 8.94 0.48 7.02e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11992162 0.967 rs7461062 chr8:11831948 T/C cg15556689 chr8:8085844 FLJ10661 0.54 6.19 0.36 2.33e-9 Monocyte count; CESC cis rs7605827 0.897 rs11892720 chr2:15674267 T/C cg19274914 chr2:15703543 NA 0.33 5.8 0.34 1.88e-8 Educational attainment (years of education); CESC cis rs7772486 0.875 rs56181683 chr6:146286620 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -10.96 -0.56 2.61e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs6088580 0.619 rs1205335 chr20:32927507 C/T cg06115741 chr20:33292138 TP53INP2 -0.44 -5.65 -0.33 4.13e-8 Glomerular filtration rate (creatinine); CESC trans rs1814175 0.817 rs4881623 chr11:49804991 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.96 -0.77 1.02e-54 Height; CESC cis rs5758511 0.514 rs5758622 chr22:42563933 C/T cg00645731 chr22:42541494 CYP2D7P1 0.59 8.74 0.47 2.7e-16 Birth weight; CESC cis rs2832191 0.646 rs2832210 chr21:30508723 T/G cg08807101 chr21:30365312 RNF160 -0.54 -6.36 -0.36 8.57e-10 Dental caries; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07870486 chr7:56019566 MRPS17 -0.51 -6.56 -0.37 2.8e-10 Asthma; CESC cis rs9479482 1.000 rs13198863 chr6:150350781 T/G cg03788504 chr6:150331562 NA -0.38 -7.07 -0.4 1.38e-11 Alopecia areata; CESC cis rs4148883 0.675 rs10015824 chr4:100074544 C/G cg13256891 chr4:100009986 ADH5 0.53 7.0 0.4 2.1e-11 Alcohol dependence; CESC cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg05340658 chr4:99064831 C4orf37 0.79 12.24 0.6 1.33e-27 Colonoscopy-negative controls vs population controls; CESC cis rs9486715 0.809 rs9486467 chr6:96971803 C/T cg18709589 chr6:96969512 KIAA0776 0.48 6.7 0.38 1.26e-10 Headache; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04497927 chr16:84225080 ADAD2 0.49 6.82 0.39 5.97e-11 Fibrinogen levels; CESC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg22823121 chr1:150693482 HORMAD1 0.48 7.1 0.4 1.14e-11 Tonsillectomy; CESC cis rs7100689 0.784 rs7082705 chr10:82170856 C/T cg00277334 chr10:82204260 NA 0.57 7.13 0.4 9.46e-12 Post bronchodilator FEV1; CESC cis rs963731 0.579 rs12471731 chr2:39225171 A/G cg04010122 chr2:39346883 SOS1 -0.65 -5.86 -0.34 1.34e-8 Corticobasal degeneration; CESC cis rs7678296 1.000 rs73126352 chr4:37215817 G/A cg06805348 chr4:37245195 KIAA1239 0.47 5.18 0.3 4.37e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14580081 chr19:45873861 ERCC2 -0.41 -6.61 -0.38 2.11e-10 Gambling; CESC cis rs1775715 0.737 rs11817598 chr10:32206259 A/G cg18675610 chr10:32216311 ARHGAP12 0.35 5.43 0.32 1.27e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs959260 0.557 rs12943902 chr17:73400627 G/C cg12999837 chr17:73267436 MIF4GD -0.52 -5.87 -0.34 1.3e-8 Systemic lupus erythematosus; CESC cis rs4986811 1.000 rs4986811 chr11:32451093 T/G cg27409910 chr11:32454216 WT1 0.48 6.17 0.35 2.59e-9 Rubella-specific interleukin-6 secretion; CESC cis rs7216064 1.000 rs2365764 chr17:65857714 G/A cg12091567 chr17:66097778 LOC651250 -0.85 -8.71 -0.47 3.45e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1045714 0.895 rs73043182 chr7:2646005 C/T cg20813462 chr7:2646259 IQCE 0.63 5.53 0.32 7.86e-8 Urate levels in lean individuals; CESC cis rs5743618 0.537 rs10019853 chr4:38765291 T/C cg02016764 chr4:38805732 TLR1 -0.34 -5.21 -0.3 3.84e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC trans rs7615952 0.641 rs7632497 chr3:125783086 A/C cg07211511 chr3:129823064 LOC729375 -0.58 -6.52 -0.37 3.56e-10 Blood pressure (smoking interaction); CESC cis rs6681460 0.966 rs10789215 chr1:67151185 C/T cg02459107 chr1:67143332 SGIP1 -0.37 -5.09 -0.3 6.92e-7 Presence of antiphospholipid antibodies; CESC cis rs6028335 0.674 rs66647661 chr20:37671577 C/T cg16355469 chr20:37678765 NA 0.52 5.15 0.3 5.19e-7 Alcohol and nicotine co-dependence; CESC cis rs2658782 0.547 rs3020065 chr11:93059899 A/G cg15737290 chr11:93063684 CCDC67 0.55 7.61 0.42 4.71e-13 Pulmonary function decline; CESC cis rs1185460 1.000 rs1614264 chr11:118942638 A/C cg23280166 chr11:118938394 VPS11 0.58 7.79 0.43 1.56e-13 Coronary artery disease; CESC trans rs875971 0.660 rs79009421 chr7:66068509 G/C cg26939375 chr7:64535504 NA -0.64 -8.64 -0.47 5.37e-16 Aortic root size; CESC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.1 0.81 4.58e-62 Prudent dietary pattern; CESC cis rs793571 0.502 rs387812 chr15:59074786 T/C cg05156742 chr15:59063176 FAM63B 0.77 11.12 0.56 8.12e-24 Schizophrenia; CESC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg03647317 chr4:187891568 NA -0.45 -6.86 -0.39 4.83e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs757081 0.636 rs664382 chr11:17206519 A/T cg00391031 chr10:72237473 KIAA1274 0.3 6.02 0.35 5.64e-9 Systolic blood pressure; CESC cis rs3087591 0.920 rs11080150 chr17:29629326 A/G cg24425628 chr17:29625626 OMG;NF1 -0.42 -5.22 -0.31 3.53e-7 Hip circumference; CESC trans rs12339966 0.643 rs2586337 chr9:11680461 G/A cg03904639 chr13:37677730 CSNK1A1L 0.39 5.99 0.35 6.65e-9 Systolic blood pressure; CESC cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg17366294 chr4:99064904 C4orf37 0.55 7.61 0.42 4.8e-13 Colonoscopy-negative controls vs population controls; CESC cis rs362272 0.545 rs2749783 chr4:3326098 A/C cg14583973 chr4:3374767 RGS12 0.32 5.65 0.33 4.18e-8 Serum sulfate level; CESC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg17949981 chr6:28129498 ZNF389 0.48 5.98 0.34 7.1e-9 Depression; CESC cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg05340658 chr4:99064831 C4orf37 0.81 12.43 0.61 3.06e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg04287289 chr16:89883240 FANCA 0.88 14.92 0.68 5.91e-37 Vitiligo; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12014145 chr16:30346812 LOC595101 0.45 6.02 0.35 5.84e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10129255 0.912 rs6576227 chr14:107186441 A/G cg23076370 chr14:107095027 NA -0.48 -6.29 -0.36 1.32e-9 Kawasaki disease; CESC cis rs17253792 0.822 rs10483650 chr14:56145312 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg23758822 chr17:41437982 NA 1.0 15.66 0.69 1.44e-39 Menopause (age at onset); CESC trans rs875971 0.522 rs1968127 chr7:66056803 C/T cg26939375 chr7:64535504 NA -0.63 -8.52 -0.46 1.24e-15 Aortic root size; CESC cis rs7843479 1.000 rs7843479 chr8:21820813 G/T cg17168535 chr8:21777572 XPO7 0.53 7.26 0.41 4.2e-12 Mean corpuscular volume; CESC cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.31 -5.11 -0.3 6.05e-7 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12451852 chr7:149468989 ZNF467 0.58 6.28 0.36 1.38e-9 Gut microbiome composition (summer); CESC cis rs1023500 0.573 rs4822088 chr22:42470589 G/C cg04733989 chr22:42467013 NAGA 0.83 12.7 0.62 3.37e-29 Schizophrenia; CESC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg01017244 chr2:74357527 NA 0.62 8.14 0.45 1.51e-14 Gestational age at birth (maternal effect); CESC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg08736216 chr1:53307985 ZYG11A -0.4 -6.76 -0.38 8.66e-11 Monocyte count; CESC cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.69 -10.85 -0.55 6.13e-23 Personality dimensions; CESC trans rs60843830 1.000 rs62114505 chr2:242426 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 8.35 0.46 3.72e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15730116 chr12:76953768 OSBPL8 0.61 7.27 0.41 3.99e-12 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg11663144 chr21:46675770 NA -0.51 -7.75 -0.43 2.01e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6964587 1.000 rs36021614 chr7:91717490 C/G cg17063962 chr7:91808500 NA 0.54 7.33 0.41 2.71e-12 Breast cancer; CESC cis rs34330 0.562 rs17212236 chr12:12855483 G/C cg09462578 chr12:12878428 APOLD1 -0.79 -8.38 -0.46 3.09e-15 Systemic lupus erythematosus; CESC cis rs10982213 0.830 rs10081697 chr9:117182605 C/G cg00969271 chr9:117093052 ORM2 0.41 5.53 0.32 7.75e-8 Interleukin-6 levels; CESC cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg12501888 chr15:85177176 SCAND2 0.47 6.13 0.35 3.17e-9 P wave terminal force; CESC cis rs8005677 1.000 rs1956880 chr14:23394007 A/G cg25600027 chr14:23388339 RBM23 -0.42 -5.18 -0.3 4.35e-7 Cognitive ability (multi-trait analysis); CESC cis rs12579753 0.879 rs12829053 chr12:82161926 T/A cg21193143 chr12:82153300 PPFIA2 -0.34 -5.04 -0.3 8.72e-7 Resting heart rate; CESC cis rs644799 0.965 rs549695 chr11:95617788 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.62 7.79 0.43 1.5e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs73110464 0.609 rs6580923 chr12:53358352 A/G cg25025879 chr12:53359317 NA -0.61 -8.11 -0.45 1.95e-14 Cancer (pleiotropy); CESC cis rs34734847 0.787 rs7976497 chr12:121135467 T/C cg26008908 chr12:120799332 MSI1 0.34 5.24 0.31 3.25e-7 Mean corpuscular volume; CESC trans rs4927850 1.000 rs7627706 chr3:195753353 A/C cg16724585 chr3:197361211 NA -0.56 -7.2 -0.4 6.32e-12 Pancreatic cancer; CESC trans rs10743315 0.557 rs78983750 chr12:19284967 C/T cg09562322 chr12:119419143 SRRM4 -0.48 -6.27 -0.36 1.48e-9 Gut microbiota (bacterial taxa); CESC cis rs1894116 0.582 rs11225138 chr11:101993898 C/G cg03447327 chr11:101977394 NA -0.57 -5.04 -0.3 8.77e-7 Polycystic ovary syndrome; CESC cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg16339924 chr4:17578868 LAP3 0.75 9.8 0.52 1.56e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1050631 0.623 rs7242481 chr18:33709217 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 7.97 0.44 4.65e-14 Esophageal squamous cell cancer (length of survival); CESC cis rs6060717 0.536 rs11699899 chr20:34525646 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -6.96 -0.39 2.72e-11 Hip circumference adjusted for BMI; CESC cis rs9549260 0.620 rs12583418 chr13:41195411 G/A cg21288729 chr13:41239152 FOXO1 0.63 8.0 0.44 3.79e-14 Red blood cell count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15803506 chr10:135125704 ZNF511 0.53 7.36 0.41 2.26e-12 Fibrinogen levels; CESC cis rs8082590 1 rs8082590 chr17:17958402 G/A cg16928487 chr17:17741425 SREBF1 0.56 9.38 0.5 3e-18 Schizophrenia; CESC cis rs11203032 0.831 rs4078488 chr10:90966546 C/T cg16672925 chr10:90967113 CH25H 0.72 7.02 0.4 1.86e-11 Heart failure; CESC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg18876405 chr7:65276391 NA -0.47 -6.39 -0.37 7.56e-10 Aortic root size; CESC cis rs7726839 0.794 rs6883536 chr5:599274 G/A cg09021430 chr5:549028 NA -0.44 -6.14 -0.35 3.06e-9 Obesity-related traits; CESC cis rs6121246 0.909 rs6060979 chr20:30417522 C/T cg13852791 chr20:30311386 BCL2L1 0.76 7.78 0.43 1.58e-13 Mean corpuscular hemoglobin; CESC trans rs7615952 0.932 rs13314869 chr3:125644669 G/A cg07211511 chr3:129823064 LOC729375 -1.13 -15.51 -0.69 4.75e-39 Blood pressure (smoking interaction); CESC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg18337363 chr3:52569053 NT5DC2 0.3 5.56 0.32 6.5e-8 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09787254 chr16:74808678 FA2H 0.69 8.04 0.44 3.06e-14 Gut microbiome composition (summer); CESC cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg25405998 chr7:65216604 CCT6P1 0.5 5.39 0.31 1.58e-7 Aortic root size; CESC cis rs5771069 0.933 rs137848 chr22:50440296 A/G cg27467552 chr22:50353597 PIM3 -0.49 -7.19 -0.4 6.72e-12 Ulcerative colitis; CESC cis rs950169 0.959 rs12911210 chr15:84792083 A/C cg17507749 chr15:85114479 UBE2QP1 0.57 6.5 0.37 3.9e-10 Schizophrenia; CESC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg06634786 chr22:41940651 POLR3H -0.63 -6.6 -0.38 2.2e-10 Vitiligo; CESC cis rs7945705 0.520 rs1984791 chr11:9035027 C/T cg12365402 chr11:9010492 NRIP3 0.42 6.55 0.37 3.02e-10 Hemoglobin concentration; CESC cis rs9811920 0.535 rs704574 chr3:99483773 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.33 5.4 0.32 1.46e-7 Axial length; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg25528940 chr16:57127044 CPNE2 -0.47 -6.18 -0.35 2.34e-9 Asthma; CESC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg06873352 chr17:61820015 STRADA -0.47 -6.9 -0.39 3.91e-11 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23715700 chr19:16188274 TPM4 0.5 6.43 0.37 5.93e-10 Gut microbiota (bacterial taxa); CESC cis rs3796352 1.000 rs2336540 chr3:52974589 G/A cg12962167 chr3:53033115 SFMBT1 0.6 5.09 0.3 6.95e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs6570726 0.935 rs446242 chr6:145843866 A/G cg05347473 chr6:146136440 FBXO30 0.47 6.33 0.36 1.02e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs13082711 0.554 rs7635958 chr3:27385616 A/C cg02860705 chr3:27208620 NA 0.77 8.7 0.47 3.67e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs709400 1.000 rs56660916 chr14:104126137 G/T cg24130564 chr14:104152367 KLC1 -0.42 -5.41 -0.32 1.44e-7 Body mass index; CESC cis rs7267979 0.773 rs6132821 chr20:25226192 A/G cg08601574 chr20:25228251 PYGB 0.42 5.81 0.34 1.82e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg16606324 chr3:10149918 C3orf24 0.43 5.45 0.32 1.12e-7 Alzheimer's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02040921 chr17:61554411 ACE -0.41 -6.17 -0.35 2.5e-9 Gambling; CESC cis rs12477438 0.520 rs6756650 chr2:99801800 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.21 0.68 5.36e-38 Chronic sinus infection; CESC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.77 0.33 2.24e-8 Menopause (age at onset); CESC cis rs6840258 0.943 rs72667748 chr4:87927034 C/T cg08197287 chr4:87952173 AFF1 -0.41 -5.56 -0.32 6.69e-8 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC cis rs8017423 0.630 rs4904678 chr14:90821670 T/C cg14092571 chr14:90743983 NA 0.45 6.82 0.39 6.23e-11 Mortality in heart failure; CESC cis rs10751667 0.621 rs10794353 chr11:948740 A/G cg06064525 chr11:970664 AP2A2 -0.5 -9.88 -0.52 8.67e-20 Alzheimer's disease (late onset); CESC cis rs13256369 0.802 rs35382339 chr8:8559255 G/A cg18904891 chr8:8559673 CLDN23 0.72 7.98 0.44 4.42e-14 Obesity-related traits; CESC cis rs2235642 0.826 rs8053605 chr16:1594158 G/A cg08296037 chr16:1584118 IFT140;TMEM204 -0.32 -5.26 -0.31 3e-7 Coronary artery disease; CESC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6496667 0.955 rs8039263 chr15:90900597 G/A cg22089800 chr15:90895588 ZNF774 0.58 5.9 0.34 1.1e-8 Rheumatoid arthritis; CESC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg18479299 chr3:125709523 NA -0.48 -5.06 -0.3 7.98e-7 Blood pressure (smoking interaction); CESC cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg02574844 chr11:5959923 NA -0.44 -5.5 -0.32 9.15e-8 DNA methylation (variation); CESC cis rs11155671 0.530 rs4458704 chr6:150232879 A/C cg09699651 chr6:150184138 LRP11 0.41 5.48 0.32 1e-7 Testicular germ cell tumor; CESC cis rs7520050 0.966 rs12405451 chr1:46384326 T/A cg24296786 chr1:45957014 TESK2 0.44 5.48 0.32 9.94e-8 Red blood cell count;Reticulocyte count; CESC cis rs15676 0.783 rs2417128 chr9:131571756 G/A cg00228799 chr9:131580591 ENDOG 0.43 5.29 0.31 2.59e-7 Blood metabolite levels; CESC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg11494091 chr17:61959527 GH2 0.72 12.11 0.6 3.6e-27 Prudent dietary pattern; CESC cis rs11583043 0.918 rs11581062 chr1:101407519 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.53 -6.19 -0.36 2.23e-9 Ulcerative colitis;Inflammatory bowel disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01740367 chr2:27294264 LOC100128731 0.45 6.05 0.35 5e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6752107 0.967 rs11680130 chr2:234157258 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.45 6.32 0.36 1.12e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs2404602 0.692 rs4360890 chr15:77173295 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.68 -0.33 3.63e-8 Blood metabolite levels; CESC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg18099408 chr3:52552593 STAB1 -0.32 -5.31 -0.31 2.35e-7 Bipolar disorder; CESC cis rs7089973 0.604 rs11196937 chr10:116589500 G/C cg03647239 chr10:116582469 FAM160B1 0.43 5.29 0.31 2.6e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00026853 chr16:30934156 NCRNA00095 0.6 6.53 0.37 3.26e-10 Gut microbiome composition (summer); CESC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg19592336 chr6:28129416 ZNF389 0.55 7.0 0.4 2.07e-11 Parkinson's disease; CESC cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg24308560 chr3:49941425 MST1R -0.64 -9.33 -0.5 4.29e-18 Intelligence (multi-trait analysis); CESC cis rs7267979 1.000 rs2259926 chr20:25281733 T/C cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9302690 0.557 rs223875 chr16:57506915 C/T cg27017172 chr16:57497170 POLR2C 0.67 5.93 0.34 9.49e-9 Blood protein levels; CESC cis rs7827545 0.701 rs6577655 chr8:135593725 C/T cg17885191 chr8:135476712 NA 0.46 5.99 0.35 6.84e-9 Hypertension (SNP x SNP interaction); CESC cis rs4568518 0.619 rs34058374 chr7:18008582 G/A cg03009463 chr7:17980271 SNX13 0.45 5.86 0.34 1.36e-8 Measles; CESC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg19346786 chr7:2764209 NA -0.49 -7.09 -0.4 1.19e-11 Height; CESC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg17971929 chr21:40555470 PSMG1 1.02 15.8 0.7 4.31e-40 Cognitive function; CESC cis rs7586673 0.578 rs6723841 chr2:161879616 G/T cg21518248 chr2:162101506 NA 0.43 5.53 0.32 7.81e-8 Intelligence (multi-trait analysis); CESC cis rs2050392 0.517 rs589980 chr10:30756385 T/A cg25182066 chr10:30743637 MAP3K8 -0.52 -7.75 -0.43 2e-13 Inflammatory bowel disease; CESC trans rs1728785 1.000 rs1749792 chr16:68569440 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.47 0.42 1.13e-12 Ulcerative colitis; CESC cis rs3780486 0.846 rs7873903 chr9:33142728 G/A cg13443165 chr9:33130375 B4GALT1 0.48 6.81 0.39 6.43e-11 IgG glycosylation; CESC cis rs287982 0.935 rs287978 chr2:9970534 T/C cg10881225 chr2:9984929 TAF1B -0.41 -5.27 -0.31 2.79e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg05340658 chr4:99064831 C4orf37 0.79 12.28 0.6 9.45e-28 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.679 rs78941440 chr8:58052095 A/G cg24829409 chr8:58192753 C8orf71 -0.48 -6.1 -0.35 3.75e-9 Developmental language disorder (linguistic errors); CESC trans rs1814175 0.645 rs7115592 chr11:50013243 A/G cg11707556 chr5:10655725 ANKRD33B -0.42 -6.12 -0.35 3.32e-9 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03837726 chr12:119633116 NA -0.45 -6.38 -0.36 7.65e-10 Gut microbiota (bacterial taxa); CESC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg03609598 chr5:56110824 MAP3K1 -0.52 -5.57 -0.32 6.2e-8 Initial pursuit acceleration; CESC cis rs8177253 0.632 rs6782523 chr3:133438917 C/T cg24879335 chr3:133465180 TF 0.31 5.13 0.3 5.64e-7 Iron status biomarkers; CESC cis rs9837602 1.000 rs62285461 chr3:99767642 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 7.51 0.42 8.91e-13 Breast cancer; CESC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs2479106 0.591 rs7855233 chr9:126328327 C/T cg16191174 chr9:126692580 DENND1A -0.37 -5.06 -0.3 8.01e-7 Polycystic ovary syndrome; CESC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg04414720 chr1:150670196 GOLPH3L 0.62 8.8 0.48 1.76e-16 Tonsillectomy; CESC cis rs672059 1.000 rs674343 chr1:183162052 G/A ch.1.3577855R chr1:183094577 LAMC1 0.54 7.05 0.4 1.59e-11 Hypertriglyceridemia; CESC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg18252515 chr7:66147081 NA 0.4 5.21 0.3 3.76e-7 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13786666 chr9:86536028 KIF27 -0.39 -6.26 -0.36 1.5e-9 Gambling; CESC cis rs2795502 1.000 rs2795497 chr10:43339475 C/A cg20628663 chr10:43360327 NA -0.63 -7.47 -0.42 1.16e-12 Blood protein levels; CESC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.3 -0.41 3.41e-12 Total body bone mineral density; CESC cis rs2274273 0.686 rs28631821 chr14:55845987 T/C cg04306507 chr14:55594613 LGALS3 0.31 6.09 0.35 4.03e-9 Protein biomarker; CESC cis rs8180040 0.681 rs9818382 chr3:47193034 C/T cg27129171 chr3:47204927 SETD2 0.67 9.81 0.52 1.36e-19 Colorectal cancer; CESC cis rs870825 0.616 rs6810635 chr4:185616859 T/C cg04058563 chr4:185651563 MLF1IP 0.65 7.08 0.4 1.31e-11 Blood protein levels; CESC cis rs559928 0.556 rs734762 chr11:63912189 G/C cg18225595 chr11:63971243 STIP1 0.64 5.82 0.34 1.73e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC trans rs853679 0.882 rs9468287 chr6:28079741 G/T cg06606381 chr12:133084897 FBRSL1 -0.67 -6.55 -0.37 2.94e-10 Depression; CESC cis rs5758659 0.652 rs133358 chr22:42442539 A/T cg05082376 chr22:42548792 NA -0.37 -5.41 -0.32 1.44e-7 Cognitive function; CESC cis rs2108225 0.872 rs6980029 chr7:107446127 T/C cg18560240 chr7:107437656 SLC26A3 -0.44 -5.92 -0.34 9.93e-9 Ulcerative colitis; CESC cis rs34779708 0.931 rs11010125 chr10:35502953 A/G cg03585969 chr10:35415529 CREM 0.75 9.86 0.52 9.85e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs10870270 0.956 rs10870293 chr10:133771413 G/A cg08754478 chr10:133766260 PPP2R2D -0.59 -7.63 -0.42 4.22e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs6728642 0.572 rs1320147 chr2:97600626 A/C cg26665480 chr2:98280029 ACTR1B 0.71 8.61 0.47 6.7e-16 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs854765 0.583 rs11078404 chr17:17820487 A/T cg16928487 chr17:17741425 SREBF1 -0.56 -9.74 -0.51 2.34e-19 Total body bone mineral density; CESC cis rs938554 0.744 rs7675964 chr4:9941434 C/T cg00071950 chr4:10020882 SLC2A9 -0.53 -7.38 -0.41 2e-12 Blood metabolite levels; CESC cis rs34779708 0.966 rs57081218 chr10:35434608 A/G cg03585969 chr10:35415529 CREM 0.75 9.83 0.52 1.2e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs7267979 0.966 rs910996 chr20:25264196 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 17.4 0.73 9.43e-46 Liver enzyme levels (alkaline phosphatase); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11259409 chr11:1331124 LOC255512;TOLLIP -0.44 -6.13 -0.35 3.14e-9 Fibrinogen levels; CESC cis rs2066819 1.000 rs116849218 chr12:56683975 C/T cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs8027181 0.804 rs7178130 chr15:72978202 A/G cg25632853 chr15:73088954 NA -0.29 -5.11 -0.3 6.14e-7 Triglyceride levels; CESC cis rs1790761 0.505 rs6591256 chr11:67349899 A/G cg00290607 chr11:67383545 NA -0.37 -5.57 -0.32 6.31e-8 Mean corpuscular volume; CESC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg23985595 chr17:80112537 CCDC57 0.42 6.56 0.37 2.87e-10 Life satisfaction; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27571676 chr16:88061218 BANP 0.44 6.01 0.35 6.26e-9 Fibrinogen levels; CESC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg00310523 chr12:86230176 RASSF9 0.37 5.86 0.34 1.41e-8 Major depressive disorder; CESC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg21144161 chr5:423903 AHRR 0.37 5.94 0.34 9e-9 Cystic fibrosis severity; CESC cis rs2708240 1.000 rs2708255 chr7:147587614 C/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.36 -5.86 -0.34 1.37e-8 QT interval (drug interaction); CESC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg23283495 chr1:209979779 IRF6 0.45 5.05 0.3 8.12e-7 Cleft lip with or without cleft palate; CESC cis rs6582630 0.519 rs8189609 chr12:38281408 A/G cg26384229 chr12:38710491 ALG10B 0.72 10.26 0.53 5.3e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg03433033 chr1:76189801 ACADM 0.68 8.05 0.44 2.87e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1595825 0.786 rs75415672 chr2:198535679 G/A cg00982548 chr2:198649783 BOLL -0.49 -5.27 -0.31 2.89e-7 Ulcerative colitis; CESC cis rs863345 0.565 rs2051665 chr1:158507157 A/T cg12129480 chr1:158549410 OR10X1 -0.35 -7.08 -0.4 1.32e-11 Pneumococcal bacteremia; CESC trans rs3749237 1.000 rs11130216 chr3:49736172 C/A cg21659725 chr3:3221576 CRBN 0.53 6.3 0.36 1.22e-9 Resting heart rate; CESC cis rs72781680 0.768 rs112139157 chr2:24150783 A/C cg08917208 chr2:24149416 ATAD2B 0.63 6.24 0.36 1.73e-9 Lymphocyte counts; CESC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg00684032 chr4:1343700 KIAA1530 0.41 6.21 0.36 2.06e-9 Longevity; CESC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg18446336 chr7:2847575 GNA12 -0.39 -6.07 -0.35 4.44e-9 Height; CESC cis rs7786808 0.741 rs4909222 chr7:158228095 C/T cg01191920 chr7:158217561 PTPRN2 0.43 7.76 0.43 1.89e-13 Obesity-related traits; CESC cis rs60154123 0.730 rs652256 chr1:210465017 T/C cg23283495 chr1:209979779 IRF6 0.41 5.36 0.31 1.79e-7 Coronary artery disease; CESC cis rs9325144 0.560 rs10506127 chr12:39126686 C/G cg26384229 chr12:38710491 ALG10B -0.5 -7.31 -0.41 3.18e-12 Morning vs. evening chronotype; CESC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg09658497 chr7:2847517 GNA12 -0.37 -5.23 -0.31 3.45e-7 Height; CESC cis rs3126085 0.935 rs3126062 chr1:152272352 G/A cg03465714 chr1:152285911 FLG 0.46 5.74 0.33 2.54e-8 Atopic dermatitis; CESC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg10541313 chr22:46663664 TTC38 0.74 5.91 0.34 1.02e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg06713675 chr4:122721982 EXOSC9 -0.52 -7.24 -0.41 4.73e-12 Type 2 diabetes; CESC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg10691866 chr7:65817282 TPST1 0.33 5.51 0.32 8.51e-8 Aortic root size; CESC cis rs6691722 0.503 rs6656485 chr1:24707685 A/G cg18323236 chr1:24743029 NIPAL3 0.37 5.46 0.32 1.1e-7 Response to interferon beta in multiple sclerosis; CESC cis rs10078 0.571 rs890977 chr5:476910 T/C cg08916839 chr5:415575 AHRR 0.6 6.77 0.38 8.3e-11 Fat distribution (HIV); CESC cis rs12477438 0.834 rs6757019 chr2:99676936 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg06481639 chr22:41940642 POLR3H 0.57 5.79 0.33 2.01e-8 Vitiligo; CESC cis rs10779751 1.000 rs10779751 chr1:11284336 A/G cg08854313 chr1:11322531 MTOR 0.79 10.62 0.55 3.5e-22 Body mass index; CESC cis rs425277 0.958 rs262688 chr1:2113565 T/G cg04315214 chr1:2043799 PRKCZ -0.37 -5.28 -0.31 2.7e-7 Height; CESC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.73 0.38 1.02e-10 Prudent dietary pattern; CESC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg24675658 chr1:53192096 ZYG11B -0.52 -6.37 -0.36 8.1e-10 Monocyte count; CESC cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg03467027 chr4:99064603 C4orf37 0.43 5.47 0.32 1.02e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3091242 0.933 rs11249250 chr1:25767609 G/A cg02931644 chr1:25747376 RHCE 0.4 6.65 0.38 1.64e-10 Erythrocyte sedimentation rate; CESC cis rs5995756 1.000 rs5995756 chr22:40000313 A/G cg03390717 chr22:39966585 CACNA1I -0.31 -5.47 -0.32 1.07e-7 Autism spectrum disorder or schizophrenia; CESC cis rs2243480 1.000 rs4718317 chr7:65648901 A/G cg12463550 chr7:65579703 CRCP -0.76 -6.01 -0.35 6.12e-9 Diabetic kidney disease; CESC cis rs11690935 0.921 rs6710698 chr2:172596078 G/C cg13550731 chr2:172543902 DYNC1I2 -1.02 -16.95 -0.72 3.83e-44 Schizophrenia; CESC cis rs8072100 0.713 rs11651643 chr17:45483229 A/G cg25173405 chr17:45401733 C17orf57 -0.44 -5.48 -0.32 9.7e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg07092213 chr7:1199455 ZFAND2A -0.37 -5.12 -0.3 5.79e-7 Longevity;Endometriosis; CESC cis rs734999 0.588 rs867435 chr1:2523706 C/T cg20673091 chr1:2541236 MMEL1 0.42 6.76 0.38 8.85e-11 Ulcerative colitis; CESC cis rs17021463 0.902 rs13102926 chr4:95245527 C/T cg11021082 chr4:95130006 SMARCAD1 0.52 7.84 0.43 1.1e-13 Testicular germ cell tumor; CESC cis rs4629180 0.586 rs57563359 chr2:102125309 A/G cg04415270 chr2:102091202 RFX8 -0.31 -5.39 -0.31 1.59e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs11785400 0.793 rs34875149 chr8:143736131 G/A cg24634471 chr8:143751801 JRK 0.45 5.75 0.33 2.42e-8 Schizophrenia; CESC cis rs2997447 0.748 rs112813126 chr1:26432239 A/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs6546550 0.933 rs57278310 chr2:70093647 T/C cg02498382 chr2:70120550 SNRNP27 -0.35 -6.01 -0.35 6.05e-9 Prevalent atrial fibrillation; CESC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg02564969 chr6:151773285 C6orf211;RMND1 0.66 9.47 0.5 1.61e-18 Menarche (age at onset); CESC cis rs8114671 0.967 rs2065979 chr20:33767690 T/C cg24642439 chr20:33292090 TP53INP2 0.44 5.26 0.31 2.95e-7 Height; CESC cis rs2354432 0.825 rs10900347 chr1:146800107 G/C cg25205988 chr1:146714368 CHD1L 1.0 13.23 0.63 5.02e-31 Mitochondrial DNA levels; CESC cis rs7149242 1.000 rs11620937 chr14:101151012 C/G cg18089426 chr14:101175970 NA 0.4 6.19 0.36 2.26e-9 Platelet count; CESC cis rs7980687 0.662 rs585522 chr12:123550813 A/G cg00376283 chr12:123451042 ABCB9 0.75 9.26 0.49 7.14e-18 Height;Educational attainment;Head circumference (infant); CESC cis rs746627 0.719 rs35337556 chr17:63863661 A/G cg07283582 chr17:63770753 CCDC46 -0.34 -5.09 -0.3 6.82e-7 Total body bone mineral density; CESC cis rs2073300 0.609 rs74809795 chr20:23372383 A/C cg16736954 chr20:23401023 NAPB 0.8 6.25 0.36 1.67e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1775715 0.870 rs1615256 chr10:32254101 T/C cg18675610 chr10:32216311 ARHGAP12 0.33 5.14 0.3 5.37e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg09658497 chr7:2847517 GNA12 -0.43 -6.24 -0.36 1.75e-9 Height; CESC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg18538332 chr22:24372958 LOC391322 -0.84 -13.14 -0.63 1.0500000000000001e-30 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7772486 0.686 rs9390349 chr6:146054430 T/G cg23711669 chr6:146136114 FBXO30 -0.86 -12.56 -0.61 1.04e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs904092 0.720 rs1230027 chr4:100183423 T/C cg12011299 chr4:100065546 ADH4 0.53 6.11 0.35 3.48e-9 Alcohol dependence; CESC cis rs12500824 0.528 rs7677266 chr4:77278251 G/A cg20311846 chr4:77356250 SHROOM3 0.37 7.07 0.4 1.4e-11 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03672602 chr19:19754555 GMIP -0.43 -6.23 -0.36 1.86e-9 Gambling; CESC cis rs2439831 0.850 rs28504496 chr15:44016883 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.7 0.43 2.77e-13 Lung cancer in ever smokers; CESC cis rs28498503 0.867 rs1841765 chr18:76644636 A/T cg00806245 chr18:76673096 NA -0.57 -5.11 -0.3 6.3e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs7927771 0.524 rs12421563 chr11:47780222 G/A cg18512352 chr11:47633146 NA -0.35 -5.47 -0.32 1.03e-7 Subjective well-being; CESC trans rs61931739 0.500 rs11053290 chr12:34582392 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.43 -0.42 1.46e-12 Morning vs. evening chronotype; CESC cis rs3749237 0.615 rs6792911 chr3:49429856 C/T cg07636037 chr3:49044803 WDR6 0.59 8.55 0.47 9.71e-16 Resting heart rate; CESC cis rs3806843 0.568 rs2530232 chr5:140082878 A/G cg16179182 chr5:140090404 VTRNA1-1 0.4 5.06 0.3 7.67e-7 Depressive symptoms (multi-trait analysis); CESC cis rs67311347 1.000 rs9874006 chr3:40471596 G/A cg24209194 chr3:40518798 ZNF619 0.47 6.09 0.35 3.92e-9 Renal cell carcinoma; CESC cis rs9457247 0.663 rs9459845 chr6:167440501 C/G cg07741184 chr6:167504864 NA 0.34 6.01 0.35 6.21e-9 Crohn's disease; CESC cis rs7772486 0.790 rs9403756 chr6:146257761 C/G cg23711669 chr6:146136114 FBXO30 -0.87 -12.22 -0.6 1.52e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs6121246 0.954 rs7266148 chr20:30431070 G/T cg13852791 chr20:30311386 BCL2L1 0.74 7.0 0.4 2.1e-11 Mean corpuscular hemoglobin; CESC trans rs55704346 0.566 rs7684466 chr4:25386468 C/T cg01822600 chr1:245751692 KIF26B 0.42 6.07 0.35 4.43e-9 Tonsillectomy; CESC cis rs17376456 0.542 rs6556833 chr5:93104707 T/C cg25358565 chr5:93447407 FAM172A 0.47 5.16 0.3 4.73e-7 Diabetic retinopathy; CESC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg19717773 chr7:2847554 GNA12 -0.47 -6.68 -0.38 1.39e-10 Height; CESC cis rs5769765 0.730 rs62233964 chr22:50317410 C/G cg02269571 chr22:50332266 NA -0.57 -6.56 -0.37 2.82e-10 Schizophrenia; CESC cis rs6542838 0.702 rs4851177 chr2:99535188 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.2 -0.3 4.06e-7 Fear of minor pain; CESC cis rs1843834 0.505 rs940317 chr2:225358118 C/T cg22455342 chr2:225449267 CUL3 0.72 9.92 0.52 6.35e-20 IgE levels in asthmatics (D.p. specific); CESC cis rs6439153 0.933 rs2630262 chr3:128677098 C/T cg24203234 chr3:128598194 ACAD9 -0.39 -5.15 -0.3 5.07e-7 Pneumococcal bacteremia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14537507 chr5:130970729 RAPGEF6 -0.57 -6.04 -0.35 5.07e-9 Gut microbiome composition (summer); CESC cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg13902645 chr11:5959945 NA -0.66 -8.01 -0.44 3.6e-14 DNA methylation (variation); CESC cis rs9457247 1.000 rs407515 chr6:167407544 G/C cg07741184 chr6:167504864 NA 0.3 5.52 0.32 8.06e-8 Crohn's disease; CESC cis rs4561483 0.798 rs456325 chr16:12012562 C/G cg08843971 chr16:11963173 GSPT1 -0.41 -5.59 -0.32 5.65e-8 Testicular germ cell tumor; CESC cis rs3766606 0.505 rs67002863 chr1:7923478 G/A cg00042356 chr1:8021962 PARK7 0.56 5.47 0.32 1.04e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08706405 chr16:3724626 TRAP1 0.45 6.15 0.35 2.87e-9 Fibrinogen levels; CESC cis rs7481584 0.624 rs421196 chr11:3048582 T/G cg25174290 chr11:3078921 CARS -0.46 -6.4 -0.37 6.86e-10 Calcium levels; CESC cis rs12618769 0.597 rs11901568 chr2:99128621 C/T cg10123293 chr2:99228465 UNC50 -0.39 -5.21 -0.3 3.8e-7 Bipolar disorder; CESC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg16743903 chr16:89593216 SPG7 -0.5 -6.42 -0.37 6.39e-10 Multiple myeloma (IgH translocation); CESC cis rs1799949 0.864 rs60309406 chr17:41435665 C/T cg05368731 chr17:41323189 NBR1 0.77 10.55 0.54 5.97e-22 Menopause (age at onset); CESC cis rs796364 0.616 rs1523818 chr2:200684704 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.57 5.26 0.31 2.91e-7 Schizophrenia; CESC trans rs7246657 0.943 rs10420754 chr19:37959372 C/G cg24637308 chr11:6592297 DNHD1 0.54 6.34 0.36 1.01e-9 Coronary artery calcification; CESC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg00149659 chr3:10157352 C3orf10 0.72 9.04 0.49 3.45e-17 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14645856 chr6:18368844 NA -0.74 -8.45 -0.46 1.9e-15 Gut microbiome composition (summer); CESC cis rs12142240 0.660 rs72885163 chr1:46807117 C/A cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg08859206 chr1:53392774 SCP2 0.54 6.88 0.39 4.29e-11 Monocyte count; CESC cis rs10751667 0.857 rs7481221 chr11:966813 G/C cg06064525 chr11:970664 AP2A2 -0.48 -9.29 -0.5 5.99e-18 Alzheimer's disease (late onset); CESC cis rs4835473 0.932 rs34781605 chr4:144706639 G/T cg25736465 chr4:144833511 NA -0.33 -5.43 -0.32 1.28e-7 Immature fraction of reticulocytes; CESC cis rs950169 0.922 rs6603022 chr15:84830170 T/C cg17507749 chr15:85114479 UBE2QP1 -0.55 -6.25 -0.36 1.66e-9 Schizophrenia; CESC cis rs138857 0.515 rs9616373 chr22:50308597 G/A cg02269571 chr22:50332266 NA -0.63 -6.15 -0.35 2.91e-9 Mean platelet volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05477027 chr19:46295590 DMWD -0.41 -6.03 -0.35 5.4e-9 Gambling; CESC cis rs4595586 0.967 rs1400280 chr12:39241240 A/G cg26384229 chr12:38710491 ALG10B -0.41 -5.86 -0.34 1.36e-8 Morning vs. evening chronotype; CESC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.99 10.56 0.54 5.53e-22 Platelet count; CESC cis rs9916302 0.861 rs752314 chr17:37410700 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.15 -0.57 6.12e-24 Glomerular filtration rate (creatinine); CESC cis rs644799 1.000 rs518919 chr11:95623313 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.47 5.52 0.32 8.22e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs881375 0.678 rs10760125 chr9:123662590 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.83 0.39 5.66e-11 Rheumatoid arthritis; CESC trans rs7246657 0.882 rs59224125 chr19:37963205 T/C cg24637308 chr11:6592297 DNHD1 0.54 6.34 0.36 1.01e-9 Coronary artery calcification; CESC cis rs6499255 0.951 rs3169315 chr16:69720964 G/A cg15192750 chr16:69999425 NA 0.42 5.03 0.3 9e-7 IgE levels; CESC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg05313129 chr8:58192883 C8orf71 -0.5 -5.23 -0.31 3.38e-7 Developmental language disorder (linguistic errors); CESC cis rs921968 0.540 rs6746040 chr2:219588890 G/T cg02176678 chr2:219576539 TTLL4 -0.43 -7.46 -0.42 1.23e-12 Mean corpuscular hemoglobin concentration; CESC cis rs977987 0.778 rs4888412 chr16:75443196 A/G cg03315344 chr16:75512273 CHST6 0.41 5.86 0.34 1.35e-8 Dupuytren's disease; CESC cis rs7851660 0.967 rs3758248 chr9:100614601 G/A cg13688889 chr9:100608707 NA -0.69 -10.57 -0.54 4.92e-22 Strep throat; CESC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg08736216 chr1:53307985 ZYG11A 0.4 6.33 0.36 1.04e-9 Monocyte count; CESC cis rs15676 0.783 rs10988120 chr9:131564695 G/C cg00228799 chr9:131580591 ENDOG -0.49 -6.09 -0.35 3.93e-9 Blood metabolite levels; CESC cis rs72781680 0.752 rs72780185 chr2:24003967 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs1670533 0.932 rs2045067 chr4:1052355 C/T cg04106633 chr4:1044584 NA 0.4 5.16 0.3 4.85e-7 Recombination rate (females); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02396668 chr19:50528878 VRK3;ZNF473 0.6 8.09 0.45 2.13e-14 Gut microbiota (bacterial taxa); CESC trans rs13098911 0.540 rs34836513 chr3:46046459 G/A cg10236987 chr1:228114221 WNT9A 0.65 6.48 0.37 4.49e-10 Celiac disease; CESC cis rs4835473 0.932 rs4125545 chr4:144909803 T/C cg25736465 chr4:144833511 NA 0.42 6.43 0.37 6.02e-10 Immature fraction of reticulocytes; CESC cis rs938554 0.784 rs7682751 chr4:9976294 A/G cg00071950 chr4:10020882 SLC2A9 0.48 5.68 0.33 3.49e-8 Blood metabolite levels; CESC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg26818010 chr10:134567672 INPP5A -0.93 -11.42 -0.57 7.74e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6912958 0.712 rs6454638 chr6:88329427 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.34 5.5 0.32 9.08e-8 Monocyte percentage of white cells; CESC cis rs1691799 0.899 rs1168304 chr12:66738667 A/C cg16791601 chr12:66731901 HELB -0.75 -13.03 -0.62 2.51e-30 White blood cell count (basophil); CESC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg26335602 chr6:28129616 ZNF389 0.53 6.86 0.39 4.94e-11 Depression; CESC cis rs7937682 0.960 rs480293 chr11:111469132 A/C cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg03433033 chr1:76189801 ACADM 0.64 6.37 0.36 8.15e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10751667 0.666 rs7395321 chr11:940280 C/T cg06064525 chr11:970664 AP2A2 -0.5 -10.04 -0.52 2.7e-20 Alzheimer's disease (late onset); CESC cis rs826838 1.000 rs7315028 chr12:38710523 G/A cg26384229 chr12:38710491 ALG10B 0.83 15.22 0.68 5.18e-38 Heart rate; CESC cis rs67311347 1.000 rs12108041 chr3:40487535 C/T cg09455208 chr3:40491958 NA 0.49 7.97 0.44 4.72e-14 Renal cell carcinoma; CESC cis rs644799 1.000 rs623191 chr11:95548359 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs708547 0.874 rs1713984 chr4:57886493 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.56 -5.74 -0.33 2.6e-8 Response to bleomycin (chromatid breaks); CESC cis rs2929278 0.589 rs11638972 chr15:44074691 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.52 -6.73 -0.38 1.05e-10 Schizophrenia; CESC cis rs2243480 1.000 rs73142162 chr7:65374296 A/T cg25894440 chr7:65020034 NA -0.63 -5.26 -0.31 2.91e-7 Diabetic kidney disease; CESC cis rs1569175 1.000 rs1509830 chr2:200908143 G/A cg19045956 chr2:200819837 C2orf60;C2orf47 0.64 5.41 0.32 1.44e-7 Response to treatment for acute lymphoblastic leukemia; CESC cis rs10504229 0.953 rs6985942 chr8:58173412 T/C cg22535103 chr8:58192502 C8orf71 -0.87 -11.17 -0.57 5.43e-24 Developmental language disorder (linguistic errors); CESC cis rs668210 0.793 rs1192184 chr11:65773382 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 -0.68 -6.75 -0.38 9.22e-11 Cerebrospinal fluid biomarker levels; CESC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs34779708 0.931 rs11010067 chr10:35295431 C/G cg04310649 chr10:35416472 CREM 0.52 6.32 0.36 1.08e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs3806843 1.000 rs10073974 chr5:140165231 T/C cg26395211 chr5:140044315 WDR55 -0.43 -5.52 -0.32 8.02e-8 Depressive symptoms (multi-trait analysis); CESC cis rs7605827 0.930 rs10929375 chr2:15684483 A/G cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs13191362 0.507 rs13212746 chr6:163203092 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.5 5.93 0.34 9.18e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg23711669 chr6:146136114 FBXO30 0.91 12.25 0.6 1.26e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs933688 1.000 rs6862125 chr5:90724598 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.13 13.94 0.65 1.68e-33 Smoking behavior; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg13939297 chr12:104461859 HCFC2 0.4 6.18 0.35 2.35e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg22467129 chr15:76604101 ETFA -0.37 -5.52 -0.32 7.96e-8 Blood metabolite levels; CESC trans rs7521492 0.647 rs3856201 chr1:163736341 G/T cg00842670 chr18:77728011 HSBP1L1 -0.38 -6.05 -0.35 4.93e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9549367 0.713 rs3024757 chr13:113823186 G/T cg00898013 chr13:113819073 PROZ -0.55 -7.42 -0.41 1.59e-12 Platelet distribution width; CESC cis rs17209837 0.607 rs1468615 chr7:87074964 T/C cg00919237 chr7:87102261 ABCB4 -0.52 -6.03 -0.35 5.4e-9 Gallbladder cancer; CESC cis rs75477785 0.793 rs9919217 chr1:210057532 G/T cg02304930 chr1:210405566 SERTAD4;C1orf133 -0.96 -6.58 -0.37 2.51e-10 Cleft lip with or without cleft palate; CESC cis rs4780401 0.933 rs7203803 chr16:11812291 A/G cg01061890 chr16:11836724 TXNDC11 0.38 5.19 0.3 4.1e-7 Rheumatoid arthritis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12600695 chr5:137513806 BRD8;KIF20A 0.49 6.28 0.36 1.42e-9 Gut microbiota (bacterial taxa); CESC cis rs7089973 0.604 rs58587374 chr10:116597572 A/G cg25233709 chr10:116636983 FAM160B1 0.38 5.97 0.34 7.44e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg20151795 chr6:28129481 ZNF389 0.48 6.41 0.37 6.55e-10 Depression; CESC cis rs6460942 0.591 rs4721078 chr7:12334657 T/A cg02935154 chr7:12443704 VWDE -0.53 -5.5 -0.32 9.01e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13843727 chr22:41601352 L3MBTL2 0.57 6.22 0.36 1.88e-9 Gut microbiome composition (summer); CESC cis rs9894429 1.000 rs7406003 chr17:79597597 C/T cg18240062 chr17:79603768 NPLOC4 0.73 10.27 0.53 4.66e-21 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13266951 chr7:2013113 MAD1L1 -0.7 -7.91 -0.44 7.05e-14 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 13.04 0.63 2.35e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg06873352 chr17:61820015 STRADA 0.72 12.79 0.62 1.64e-29 Prudent dietary pattern; CESC cis rs10089 1.000 rs2898096 chr5:127433214 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.77 10.42 0.54 1.57e-21 Ileal carcinoids; CESC cis rs9948 0.786 rs111237064 chr2:97456578 T/C cg01990225 chr2:97406019 LMAN2L -0.93 -7.38 -0.41 2.02e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg16144293 chr14:75469539 EIF2B2 0.41 5.21 0.3 3.79e-7 Height; CESC cis rs921968 0.528 rs13022583 chr2:219589175 T/C cg02176678 chr2:219576539 TTLL4 -0.43 -7.59 -0.42 5.51e-13 Mean corpuscular hemoglobin concentration; CESC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.850 rs11076623 chr16:89844120 G/T cg14709524 chr16:89940631 TCF25 0.91 6.72 0.38 1.09e-10 Skin colour saturation; CESC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg21963583 chr11:68658836 MRPL21 -0.42 -5.91 -0.34 1.07e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8067354 0.574 rs2531899 chr17:58007193 A/G cg02344993 chr17:57696989 CLTC -0.55 -5.67 -0.33 3.67e-8 Hemoglobin concentration; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09126467 chr6:42796794 KIAA0240 -0.47 -6.04 -0.35 5.21e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6570726 1.000 rs386678 chr6:145869010 A/G cg05347473 chr6:146136440 FBXO30 0.45 6.23 0.36 1.83e-9 Lobe attachment (rater-scored or self-reported); CESC trans rs747782 0.585 rs1604655 chr11:48274778 G/A cg15704280 chr7:45808275 SEPT13 0.69 6.44 0.37 5.65e-10 Intraocular pressure; CESC cis rs3126085 1.000 rs55957623 chr1:152223196 T/A cg03465714 chr1:152285911 FLG 0.45 5.13 0.3 5.74e-7 Atopic dermatitis; CESC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg08470875 chr2:26401718 FAM59B -0.47 -5.24 -0.31 3.31e-7 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg08888203 chr3:10149979 C3orf24 0.51 6.33 0.36 1.02e-9 Alzheimer's disease; CESC cis rs12586317 0.547 rs4982236 chr14:35468046 C/G cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC cis rs4925386 0.625 rs3810550 chr20:60912117 C/T cg06026331 chr20:60912101 LAMA5 0.48 5.05 0.3 8.41e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs7246657 0.943 rs2303131 chr19:37936025 G/A cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.3 -5.36 -0.31 1.82e-7 Bipolar disorder; CESC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg06138931 chr13:21896616 NA 0.49 6.54 0.37 3.07e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg24675658 chr1:53192096 ZYG11B 0.49 6.31 0.36 1.18e-9 Monocyte count; CESC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.91 0.34 1.03e-8 Tonsillectomy; CESC cis rs9911578 0.933 rs74370218 chr17:57095212 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.05 -0.3 8.2e-7 Intelligence (multi-trait analysis); CESC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg13206674 chr6:150067644 NUP43 0.43 5.98 0.34 7.33e-9 Lung cancer; CESC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1448094 0.872 rs12322940 chr12:86406708 G/C cg02569458 chr12:86230093 RASSF9 0.33 5.05 0.3 8.33e-7 Major depressive disorder; CESC cis rs11608355 0.545 rs12822974 chr12:109909154 G/T cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7786877 0.508 rs11765509 chr7:100310990 T/G cg20848291 chr7:100343083 ZAN -0.73 -8.95 -0.48 6.21e-17 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1105228 0.501 rs4709075 chr6:165665299 A/G cg12582777 chr6:165658423 NA -0.41 -7.08 -0.4 1.28e-11 Number of pregnancies;Number of children; CESC cis rs7737355 0.812 rs7731773 chr5:130973943 A/G cg06307176 chr5:131281290 NA 0.38 5.06 0.3 7.77e-7 Life satisfaction; CESC cis rs1005277 0.579 rs1780130 chr10:38485378 T/A cg25427524 chr10:38739819 LOC399744 -0.7 -10.22 -0.53 7.1e-21 Extrinsic epigenetic age acceleration; CESC cis rs1847202 0.859 rs4566476 chr3:72948995 G/C cg10804678 chr3:72788309 NA -0.39 -5.29 -0.31 2.51e-7 Motion sickness; CESC cis rs7662987 0.517 rs2602880 chr4:100040653 C/T cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC cis rs28489187 0.706 rs233095 chr1:85824816 T/C cg16011679 chr1:85725395 C1orf52 0.54 6.21 0.36 2.05e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03552472 chr10:51623769 TIMM23 0.56 6.25 0.36 1.65e-9 Gut microbiome composition (summer); CESC cis rs897080 0.552 rs1067383 chr2:44645911 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 6.04 0.35 5.16e-9 Height; CESC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs17253792 0.822 rs75115817 chr14:56069537 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03193865 chr8:145510099 BOP1 -0.65 -7.22 -0.41 5.54e-12 Gut microbiome composition (summer); CESC cis rs4835473 0.714 rs10013005 chr4:144632504 G/A cg25736465 chr4:144833511 NA 0.4 6.24 0.36 1.74e-9 Immature fraction of reticulocytes; CESC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg21951975 chr1:209979733 IRF6 0.62 9.51 0.5 1.24e-18 Cleft lip with or without cleft palate; CESC cis rs344364 0.511 rs2982447 chr16:1947413 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 0.57 6.43 0.37 5.87e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs17407555 0.606 rs59871456 chr4:10014441 G/A cg11266682 chr4:10021025 SLC2A9 -0.51 -6.08 -0.35 4.18e-9 Schizophrenia (age at onset); CESC cis rs4851870 0.834 rs13026762 chr2:106449363 A/G cg16077055 chr2:106428750 NCK2 -0.39 -5.05 -0.3 8.15e-7 Addiction; CESC cis rs9309473 0.539 rs6732440 chr2:73827099 T/G cg20560298 chr2:73613845 ALMS1 0.5 7.05 0.4 1.58e-11 Metabolite levels; CESC cis rs2425143 1.000 rs7264414 chr20:34446826 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.78 -7.05 -0.4 1.57e-11 Blood protein levels; CESC cis rs6502050 0.805 rs7225560 chr17:80160884 C/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.27 -0.31 2.86e-7 Life satisfaction; CESC cis rs2404602 0.692 rs8024476 chr15:76983954 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.07 -0.3 7.37e-7 Blood metabolite levels; CESC cis rs2404602 0.692 rs12910734 chr15:77149931 A/G cg22467129 chr15:76604101 ETFA -0.34 -5.18 -0.3 4.47e-7 Blood metabolite levels; CESC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.71 -0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7662987 0.517 rs2602881 chr4:100040695 A/G cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC cis rs11971779 0.818 rs12056045 chr7:139025430 C/G cg07862535 chr7:139043722 LUC7L2 0.52 5.45 0.32 1.17e-7 Diisocyanate-induced asthma; CESC cis rs12681366 0.734 rs716770 chr8:95390921 C/T cg13257157 chr8:95487014 RAD54B 0.38 5.11 0.3 6.3e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs10504229 0.773 rs60466370 chr8:58171248 A/C cg24829409 chr8:58192753 C8orf71 -0.62 -8.61 -0.47 6.73e-16 Developmental language disorder (linguistic errors); CESC cis rs2485892 0.553 rs4844954 chr1:210337043 A/G cg22029157 chr1:209979665 IRF6 0.51 5.84 0.34 1.55e-8 Manic episodes in bipolar disorder; CESC cis rs3740713 1.000 rs73440610 chr11:18464469 T/C cg23797887 chr11:18477753 LDHAL6A -0.53 -5.13 -0.3 5.58e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg24503407 chr1:205819492 PM20D1 0.37 5.18 0.3 4.39e-7 Prostate-specific antigen levels; CESC cis rs897984 0.646 rs9938088 chr16:30830004 G/A cg00531865 chr16:30841666 NA -0.57 -8.42 -0.46 2.4e-15 Dementia with Lewy bodies; CESC cis rs9611565 0.765 rs132914 chr22:41805749 T/C cg03806693 chr22:41940476 POLR3H 1.04 12.37 0.61 4.76e-28 Vitiligo; CESC cis rs6696846 0.777 rs9651228 chr1:205049383 A/G cg00857998 chr1:205179979 DSTYK 0.5 6.72 0.38 1.1e-10 Red blood cell count; CESC cis rs62229266 0.740 rs4817759 chr21:37389559 G/A cg12218747 chr21:37451666 NA -0.4 -5.65 -0.33 4.06e-8 Mitral valve prolapse; CESC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg26408565 chr15:76604113 ETFA -0.41 -5.98 -0.34 7.19e-9 Blood metabolite levels; CESC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg25405998 chr7:65216604 CCT6P1 -0.51 -5.44 -0.32 1.24e-7 Aortic root size; CESC cis rs208520 0.837 rs208467 chr6:66914837 T/C cg07460842 chr6:66804631 NA -0.87 -10.57 -0.54 5.25e-22 Exhaled nitric oxide output; CESC cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.73 9.02 0.48 3.82e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs2742234 0.504 rs7093409 chr10:43740067 A/G cg15436174 chr10:43711423 RASGEF1A 0.46 5.49 0.32 9.56e-8 Hirschsprung disease; CESC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4948102 0.731 rs6593292 chr7:56043037 G/C cg09872392 chr7:56161020 PHKG1 -0.46 -7.25 -0.41 4.59e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs9457247 0.935 rs1794697 chr6:167395410 C/T cg23791538 chr6:167370224 RNASET2 -0.61 -8.66 -0.47 4.86e-16 Crohn's disease; CESC cis rs11098499 0.754 rs11098502 chr4:120252063 T/A cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs3096299 0.934 rs9927904 chr16:89462847 G/A cg08392591 chr16:89556376 ANKRD11 0.4 5.17 0.3 4.58e-7 Multiple myeloma (IgH translocation); CESC cis rs17253792 0.822 rs79483507 chr14:56164718 G/T cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs1670533 1.000 rs6599279 chr4:1058833 G/A cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.69e-7 Recombination rate (females); CESC cis rs12142240 0.730 rs56030283 chr1:46823093 C/G cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs12325245 0.536 rs35908812 chr16:58587426 T/C cg02549819 chr16:58548995 SETD6 0.96 6.42 0.37 6.42e-10 Schizophrenia; CESC cis rs2425143 1.000 rs4602287 chr20:34368028 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.8 7.75 0.43 1.96e-13 Blood protein levels; CESC cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg22875332 chr1:76189707 ACADM -0.73 -10.23 -0.53 6.21e-21 Blood metabolite levels;Acylcarnitine levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03758523 chr6:151773469 C6orf211;RMND1 -0.48 -6.11 -0.35 3.49e-9 Ulcerative colitis; CESC cis rs393155 0.517 rs330050 chr8:9087679 G/C cg17143192 chr8:8559678 CLDN23 -0.44 -5.34 -0.31 1.99e-7 Neuroticism; CESC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.2 0.3 4.04e-7 Electroencephalogram traits; CESC cis rs6500395 0.735 rs16946340 chr16:48667717 G/A cg04672837 chr16:48644449 N4BP1 0.45 5.55 0.32 7.01e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.19 0.4 6.47e-12 Bipolar disorder; CESC cis rs12586317 0.547 rs2038254 chr14:35462134 C/T cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg13206674 chr6:150067644 NUP43 0.41 5.7 0.33 3.16e-8 Lung cancer; CESC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg02725872 chr8:58115012 NA -0.43 -6.83 -0.39 5.9e-11 Developmental language disorder (linguistic errors); CESC cis rs2116941 1.000 rs8104426 chr19:10338676 G/T cg01850179 chr19:10340795 S1PR2 0.6 7.81 0.43 1.37e-13 Pulse pressure; CESC cis rs116095464 0.558 rs59113266 chr5:279965 T/C cg20965017 chr5:231967 SDHA -0.46 -5.2 -0.3 4.02e-7 Breast cancer; CESC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg03264133 chr6:25882463 NA -0.45 -6.45 -0.37 5.28e-10 Intelligence (multi-trait analysis); CESC cis rs1620921 0.524 rs7450979 chr6:161186889 A/C cg01280913 chr6:161186852 NA 0.43 6.47 0.37 4.78e-10 Lipoprotein (a) - cholesterol levels; CESC cis rs854765 0.623 rs9893690 chr17:17753846 A/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.43 -5.64 -0.33 4.46e-8 Total body bone mineral density; CESC cis rs668210 0.793 rs1786172 chr11:65770658 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.7 7.77 0.43 1.72e-13 Cerebrospinal fluid biomarker levels; CESC cis rs733175 0.855 rs10016075 chr4:10006663 G/T cg00071950 chr4:10020882 SLC2A9 0.56 6.66 0.38 1.6e-10 Psychosis and Alzheimer's disease; CESC cis rs6502050 0.835 rs8073351 chr17:80127625 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.97e-7 Life satisfaction; CESC trans rs6951245 0.706 rs28483034 chr7:1170171 C/A cg13565492 chr6:43139072 SRF -0.61 -6.51 -0.37 3.65e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2180341 1.000 rs3798852 chr6:127636733 A/G cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6.31e-39 Breast cancer; CESC cis rs7903847 0.646 rs10882924 chr10:99159304 T/A cg20016023 chr10:99160130 RRP12 -0.3 -5.22 -0.31 3.54e-7 Granulocyte percentage of myeloid white cells; CESC cis rs1048238 0.506 rs12023422 chr1:16187625 G/A cg21385522 chr1:16154831 NA 0.42 5.26 0.31 2.93e-7 Systolic blood pressure; CESC cis rs7560272 0.538 rs17434634 chr2:73922926 T/A cg20560298 chr2:73613845 ALMS1 0.45 6.11 0.35 3.58e-9 Schizophrenia; CESC cis rs17826219 0.636 rs79565452 chr17:29142841 T/C cg19761014 chr17:28927070 LRRC37B2 0.78 6.39 0.37 7.53e-10 Body mass index; CESC cis rs2415984 0.622 rs12434073 chr14:46921265 G/A cg14871534 chr14:47121158 RPL10L -0.35 -5.26 -0.31 2.98e-7 Number of children ever born; CESC cis rs2637266 0.935 rs2579771 chr10:78407544 A/G cg18941641 chr10:78392320 NA 0.44 8.4 0.46 2.76e-15 Pulmonary function; CESC cis rs727505 1.000 rs56356267 chr7:124557549 A/G cg23710748 chr7:124431027 NA -0.47 -7.33 -0.41 2.85e-12 Lewy body disease; CESC cis rs9929218 0.551 rs7201437 chr16:68727130 A/C cg01251360 chr16:68772225 CDH1 -0.22 -5.04 -0.3 8.74e-7 Colorectal cancer; CESC trans rs2018683 0.677 rs2057956 chr7:28973460 G/A cg19402173 chr7:128379420 CALU -0.51 -6.61 -0.38 2.09e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7680126 0.633 rs28378345 chr4:10209897 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -5.08 -0.3 7.16e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs73001065 0.551 rs56397647 chr19:19642795 C/T cg03709012 chr19:19516395 GATAD2A 1.01 7.64 0.43 3.85e-13 LDL cholesterol; CESC trans rs16949788 1.000 rs11071894 chr15:66773733 A/C cg23949574 chr2:240302855 HDAC4 -0.46 -6.55 -0.37 2.93e-10 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs826838 0.868 rs12322306 chr12:39130021 A/G cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs11997175 0.599 rs66474258 chr8:33640225 A/T ch.8.33884649F chr8:33765107 NA 0.65 8.35 0.46 3.84e-15 Body mass index; CESC cis rs7635838 0.892 rs9836167 chr3:11493392 C/T cg00170343 chr3:11313890 ATG7 0.44 6.04 0.35 5.27e-9 HDL cholesterol; CESC trans rs11039798 1.000 rs10838918 chr11:48507449 A/G cg15704280 chr7:45808275 SEPT13 0.69 6.14 0.35 3.07e-9 Axial length; CESC cis rs6466055 0.604 rs1204078 chr7:104986644 A/T cg04380332 chr7:105027541 SRPK2 0.43 5.6 0.33 5.33e-8 Schizophrenia; CESC trans rs11098499 0.575 rs907205 chr4:120238664 G/C cg25214090 chr10:38739885 LOC399744 0.61 8.51 0.46 1.33e-15 Corneal astigmatism; CESC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01501135 chr17:16342235 NCRNA00188;SNORD49B;SNORD49A -0.44 -6.17 -0.35 2.58e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.9e-10 Life satisfaction; CESC cis rs7914558 1.000 rs943036 chr10:104836047 T/C cg04362960 chr10:104952993 NT5C2 0.48 6.47 0.37 4.65e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9329289 0.603 rs2458698 chr10:2548452 C/T cg15501526 chr10:2543763 NA 0.61 9.9 0.52 7.18e-20 Age-related hearing impairment; CESC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.85 0.39 5.06e-11 Bipolar disorder; CESC cis rs2439831 1.000 rs471229 chr15:43733994 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.84 11.9 0.59 1.84e-26 Lung cancer in ever smokers; CESC cis rs72945132 0.882 rs56368270 chr11:70162590 A/G cg00319359 chr11:70116639 PPFIA1 0.8 7.52 0.42 8.55e-13 Coronary artery disease; CESC cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg02574844 chr11:5959923 NA -0.41 -5.12 -0.3 6.01e-7 DNA methylation (variation); CESC cis rs921968 0.541 rs832798 chr2:219464810 G/A cg02176678 chr2:219576539 TTLL4 0.48 8.34 0.46 4.09e-15 Mean corpuscular hemoglobin concentration; CESC cis rs9911578 1.000 rs8071280 chr17:57010225 T/C cg12560992 chr17:57184187 TRIM37 0.92 15.19 0.68 6.64e-38 Intelligence (multi-trait analysis); CESC cis rs76878669 0.561 rs2279862 chr11:66135179 C/T cg18002602 chr11:66138449 SLC29A2 0.4 6.68 0.38 1.42e-10 Educational attainment (years of education); CESC trans rs3808502 0.574 rs4841559 chr8:11416885 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -6.12 -0.35 3.44e-9 Neuroticism; CESC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg27478167 chr7:817139 HEATR2 -0.47 -5.05 -0.3 8.35e-7 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15763497 chr22:18256852 BID 0.64 7.17 0.4 7.49e-12 Gut microbiome composition (summer); CESC cis rs6963495 0.818 rs73192122 chr7:105171471 G/A cg13798780 chr7:105162888 PUS7 0.77 7.88 0.44 8.3e-14 Bipolar disorder (body mass index interaction); CESC cis rs4654899 0.865 rs12119348 chr1:21484633 C/T cg05370193 chr1:21551575 ECE1 0.46 7.08 0.4 1.28e-11 Superior frontal gyrus grey matter volume; CESC cis rs2932538 0.883 rs6537740 chr1:113080084 T/G cg22162597 chr1:113214053 CAPZA1 0.58 6.98 0.39 2.37e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09529537 chr5:78531947 JMY 0.48 6.37 0.36 8.52e-10 Gut microbiota (bacterial taxa); CESC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg17376030 chr22:41985996 PMM1 -0.77 -8.07 -0.44 2.39e-14 Crohn's disease;Inflammatory bowel disease; CESC cis rs8078723 0.701 rs2305482 chr17:38140927 A/C cg17467752 chr17:38218738 THRA -0.54 -8.09 -0.45 2.16e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs9611565 0.559 rs4822048 chr22:41988225 C/T cg06634786 chr22:41940651 POLR3H -0.67 -6.46 -0.37 4.85e-10 Vitiligo; CESC cis rs763121 1.000 rs138457 chr22:38898051 T/C cg06022373 chr22:39101656 GTPBP1 -0.75 -11.64 -0.58 1.47e-25 Menopause (age at onset); CESC cis rs1878047 0.665 rs7249595 chr19:51774613 G/A cg14884932 chr19:51774451 NA -0.37 -5.16 -0.3 4.82e-7 Body mass index; CESC cis rs10170846 1.000 rs10170846 chr2:223517705 C/G cg25565276 chr2:223520875 FARSB -0.68 -9.8 -0.52 1.47e-19 Schizophrenia (inflammation and infection response interaction); CESC cis rs1348850 0.526 rs6433672 chr2:178378175 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.66 6.02 0.35 5.75e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs727563 0.636 rs2187795 chr22:42092225 C/A cg17376030 chr22:41985996 PMM1 -0.78 -8.3 -0.45 5.4e-15 Crohn's disease;Inflammatory bowel disease; CESC cis rs9341835 0.518 rs2622294 chr6:64218316 T/A cg03326410 chr6:64151739 NA 0.32 5.15 0.3 5.1e-7 Schizophrenia; CESC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg07395648 chr5:131743802 NA 0.42 5.54 0.32 7.34e-8 Breast cancer; CESC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg07701084 chr6:150067640 NUP43 0.48 6.7 0.38 1.28e-10 Lung cancer; CESC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg05754148 chr16:3507555 NAT15 0.57 8.5 0.46 1.42e-15 Tuberculosis; CESC trans rs634534 0.622 rs1192168 chr11:65730945 T/G cg17712092 chr4:129076599 LARP1B 0.62 8.29 0.45 5.55e-15 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg03433033 chr1:76189801 ACADM 0.62 6.36 0.36 8.72e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3747547 0.892 rs1976936 chr9:37955433 G/A cg13774184 chr9:37916125 SHB -0.68 -5.71 -0.33 3.06e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs9467773 0.595 rs7767847 chr6:26597893 A/T cg24633756 chr6:26577808 NA 0.38 5.76 0.33 2.28e-8 Intelligence (multi-trait analysis); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg06988368 chr1:147142773 ACP6 0.53 6.78 0.38 7.69e-11 Breast cancer;Type 2 diabetes; CESC cis rs9549260 0.755 rs2755214 chr13:41149345 T/G cg21288729 chr13:41239152 FOXO1 0.63 7.93 0.44 6.03e-14 Red blood cell count; CESC cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 3.05e-8 Mean platelet volume; CESC cis rs3806843 0.766 rs6848 chr5:140086062 A/T cg26395211 chr5:140044315 WDR55 0.45 6.03 0.35 5.45e-9 Depressive symptoms (multi-trait analysis); CESC cis rs7786808 0.608 rs7784758 chr7:158214386 A/G cg09998033 chr7:158218633 PTPRN2 -0.37 -5.65 -0.33 4.14e-8 Obesity-related traits; CESC cis rs6541297 0.645 rs2296065 chr1:230301776 G/A cg20703242 chr1:230279135 GALNT2 0.56 6.6 0.38 2.29e-10 Coronary artery disease; CESC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs12711979 0.765 rs13028529 chr2:3825467 C/T cg17052675 chr2:3827356 NA -0.43 -6.76 -0.38 8.94e-11 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs11098499 0.954 rs11722872 chr4:120233030 G/C cg09307838 chr4:120376055 NA 0.92 12.74 0.62 2.59e-29 Corneal astigmatism; CESC cis rs78707713 0.512 rs12412776 chr10:71179502 G/A cg12610070 chr10:71211762 TSPAN15 -0.38 -7.94 -0.44 5.74e-14 Venous thromboembolism; CESC cis rs7605827 0.930 rs6431695 chr2:15539816 T/C cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs2191566 0.576 rs414402 chr19:44492568 A/G cg20607764 chr19:44506953 ZNF230 0.45 5.66 0.33 3.96e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs7904368 0.754 rs17139234 chr10:16849732 G/T cg23933602 chr10:16859644 RSU1 0.66 5.91 0.34 1.07e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg09509183 chr1:209979624 IRF6 0.47 5.67 0.33 3.78e-8 Cleft lip with or without cleft palate; CESC cis rs10754283 0.934 rs1934043 chr1:90106645 C/T cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg00815214 chr21:47717953 NA -0.43 -6.24 -0.36 1.7e-9 Testicular germ cell tumor; CESC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg24562669 chr7:97807699 LMTK2 0.48 6.8 0.39 6.74e-11 Prostate cancer (SNP x SNP interaction); CESC trans rs10100465 0.596 rs218009 chr8:118716275 A/G cg20949383 chr7:92465230 CDK6 0.63 6.23 0.36 1.84e-9 Leprosy; CESC cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg11941060 chr3:133502564 NA -0.55 -7.47 -0.42 1.18e-12 Iron status biomarkers; CESC cis rs877282 0.898 rs11253352 chr10:766598 C/A cg17470449 chr10:769945 NA 0.48 5.39 0.31 1.57e-7 Uric acid levels; CESC cis rs2274273 0.744 rs8011808 chr14:55823344 A/T cg04306507 chr14:55594613 LGALS3 0.32 6.23 0.36 1.85e-9 Protein biomarker; CESC cis rs9818758 0.607 rs11706052 chr3:49064110 A/G cg00383909 chr3:49044727 WDR6 0.9 6.12 0.35 3.41e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg11644478 chr21:40555479 PSMG1 1.01 16.32 0.71 6.16e-42 Cognitive function; CESC cis rs1023500 0.505 rs134878 chr22:42663874 A/G cg04733989 chr22:42467013 NAGA 0.65 9.57 0.51 7.66e-19 Schizophrenia; CESC cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.09e-28 Colonoscopy-negative controls vs population controls; CESC cis rs12540874 0.698 rs12718574 chr7:50573848 G/C cg18232548 chr7:50535776 DDC -0.41 -5.86 -0.34 1.36e-8 Systemic sclerosis; CESC cis rs2404602 0.692 rs4442773 chr15:77031633 T/C cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg12463550 chr7:65579703 CRCP 0.58 7.41 0.41 1.67e-12 Aortic root size; CESC cis rs9300255 0.510 rs1790086 chr12:123672518 A/G cg00376283 chr12:123451042 ABCB9 0.72 8.91 0.48 8.62e-17 Neutrophil percentage of white cells; CESC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg21770322 chr7:97807741 LMTK2 0.57 8.63 0.47 5.93e-16 Prostate cancer (SNP x SNP interaction); CESC trans rs997295 0.529 rs12592315 chr15:68040266 A/G cg05153347 chr5:171434267 FBXW11 0.5 6.48 0.37 4.53e-10 Motion sickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12157519 chr9:72874251 SMC5 0.69 7.63 0.42 4.26e-13 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg22920501 chr2:26401640 FAM59B -0.67 -8.09 -0.44 2.22e-14 Gut microbiome composition (summer); CESC cis rs55986470 0.817 rs10177049 chr2:239422169 G/T cg18131467 chr2:239335373 ASB1 -0.58 -5.29 -0.31 2.52e-7 Chronotype; CESC cis rs113835537 0.529 rs11227514 chr11:66286627 G/A cg24851651 chr11:66362959 CCS 0.43 5.35 0.31 1.87e-7 Airway imaging phenotypes; CESC trans rs13098911 0.540 rs34849862 chr3:46001367 C/A cg10236987 chr1:228114221 WNT9A 0.57 6.07 0.35 4.38e-9 Celiac disease; CESC cis rs8062405 0.573 rs7187575 chr16:28990101 C/T cg08761264 chr16:28874980 SH2B1 0.44 5.04 0.3 8.54e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg13206674 chr6:150067644 NUP43 0.43 5.94 0.34 8.78e-9 Lung cancer; CESC cis rs17539620 0.624 rs74551216 chr6:154840524 T/C cg20019720 chr6:154832845 CNKSR3 0.44 5.59 0.32 5.6e-8 Lipoprotein (a) levels; CESC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs4253772 0.720 rs4253778 chr22:46630634 C/G cg24881330 chr22:46731750 TRMU 0.73 7.92 0.44 6.56e-14 LDL cholesterol;Cholesterol, total; CESC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg16278512 chr7:12443529 VWDE -0.5 -5.08 -0.3 7.3e-7 Coronary artery disease; CESC cis rs4843747 0.671 rs72818576 chr16:88111019 C/G cg17633681 chr16:88106987 BANP 0.79 10.89 0.56 4.68e-23 Menopause (age at onset); CESC cis rs6831352 0.918 rs17218239 chr4:100057020 G/A cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg12826209 chr6:26865740 GUSBL1 0.73 8.25 0.45 7.45e-15 Intelligence (multi-trait analysis); CESC cis rs12410462 0.681 rs12401677 chr1:227608577 T/C cg04117972 chr1:227635322 NA 0.8 7.32 0.41 2.98e-12 Major depressive disorder; CESC cis rs4803468 1.000 rs2241711 chr19:41911980 T/C cg09537434 chr19:41945824 ATP5SL -1.09 -19.79 -0.77 3.84e-54 Height; CESC cis rs6964587 0.626 rs9008 chr7:91502407 C/G cg17063962 chr7:91808500 NA -0.45 -6.35 -0.36 9.22e-10 Breast cancer; CESC cis rs4629180 1.000 rs11123889 chr2:102107180 G/A cg04415270 chr2:102091202 RFX8 0.47 7.52 0.42 8.29e-13 Chronic rhinosinusitis with nasal polyps; CESC cis rs9467711 0.606 rs9393707 chr6:26362486 T/C cg12826209 chr6:26865740 GUSBL1 0.62 5.4 0.32 1.45e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7219021 1.000 rs7219021 chr17:46840541 A/C cg16584676 chr17:46985605 UBE2Z -0.65 -7.29 -0.41 3.64e-12 Schizophrenia or bipolar disorder; CESC cis rs9811920 0.599 rs1688758 chr3:99539890 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -5.85 -0.34 1.48e-8 Axial length; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06164187 chr2:242641258 ING5 0.57 6.13 0.35 3.11e-9 Gut microbiome composition (summer); CESC cis rs12042107 0.740 rs10801825 chr1:91206170 C/A cg13456504 chr1:91191583 NA -0.33 -5.76 -0.33 2.32e-8 Educational attainment; CESC cis rs870825 0.860 rs60523653 chr4:185604676 T/C cg04058563 chr4:185651563 MLF1IP 0.54 5.24 0.31 3.27e-7 Blood protein levels; CESC cis rs782590 0.537 rs7575170 chr2:55886780 C/T cg18811423 chr2:55921094 PNPT1 -0.6 -8.04 -0.44 3.03e-14 Metabolic syndrome; CESC cis rs959260 1.000 rs959260 chr17:73369422 C/T cg20590849 chr17:73267439 MIF4GD -0.55 -6.44 -0.37 5.48e-10 Systemic lupus erythematosus; CESC cis rs5758659 0.652 rs133358 chr22:42442539 A/T cg15557168 chr22:42548783 NA -0.49 -7.6 -0.42 5.27e-13 Cognitive function; CESC trans rs11098499 0.863 rs1383532 chr4:120434404 A/T cg25214090 chr10:38739885 LOC399744 -0.7 -9.78 -0.51 1.74e-19 Corneal astigmatism; CESC cis rs12142240 0.698 rs67487250 chr1:46811333 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.85 0.43 1.05e-13 Menopause (age at onset); CESC cis rs4654899 0.965 rs4654898 chr1:21376383 T/C cg05370193 chr1:21551575 ECE1 0.36 5.36 0.31 1.85e-7 Superior frontal gyrus grey matter volume; CESC trans rs2388082 0.711 rs12583304 chr13:29967668 C/T cg18754342 chr12:14849268 GUCY2C -0.65 -6.0 -0.35 6.63e-9 Insomnia (caffeine-induced); CESC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg25036284 chr2:26402008 FAM59B 0.7 6.91 0.39 3.51e-11 Gut microbiome composition (summer); CESC cis rs1801251 1.000 rs71421663 chr2:233619131 A/G cg08000102 chr2:233561755 GIGYF2 0.67 9.48 0.5 1.53e-18 Coronary artery disease; CESC cis rs17666538 0.585 rs1037393 chr8:622634 G/C cg02524346 chr8:600233 NA 0.84 5.97 0.34 7.53e-9 IgG glycosylation; CESC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.44 0.64 9.54e-32 Prudent dietary pattern; CESC cis rs1957429 0.901 rs7143661 chr14:65378981 G/A cg23373153 chr14:65346875 NA 0.91 9.83 0.52 1.19e-19 Pediatric areal bone mineral density (radius); CESC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.69 5.7 0.33 3.17e-8 Platelet count; CESC cis rs2820292 0.500 rs61824384 chr1:201859213 A/G cg11586189 chr1:201857591 SHISA4 -0.35 -5.65 -0.33 4.1e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs1797885 0.510 rs2442802 chr3:12608045 A/C cg26432171 chr3:12704882 RAF1 -0.4 -5.14 -0.3 5.21e-7 Immature fraction of reticulocytes; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg25987502 chr17:6899865 ALOX12 0.45 7.38 0.41 2.06e-12 Tonsillectomy; CESC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg26566898 chr11:117069891 TAGLN -0.32 -5.31 -0.31 2.37e-7 Blood protein levels; CESC cis rs748404 0.660 rs2249952 chr15:43720533 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.13 0.45 1.61e-14 Lung cancer; CESC cis rs9916302 0.904 rs602688 chr17:37439496 C/T cg00129232 chr17:37814104 STARD3 -0.55 -7.38 -0.41 2.09e-12 Glomerular filtration rate (creatinine); CESC cis rs13253111 0.624 rs13277389 chr8:28100234 G/T cg26534493 chr8:28060551 NA 0.46 7.15 0.4 8.56e-12 Childhood body mass index; CESC cis rs2235642 0.750 rs2755185 chr16:1645827 A/G cg03771183 chr16:1608904 IFT140 0.37 5.41 0.32 1.39e-7 Coronary artery disease; CESC cis rs77956314 0.515 rs10850733 chr12:117380961 G/A cg16111737 chr12:117408163 FBXW8 -0.46 -5.75 -0.33 2.41e-8 Subcortical brain region volumes;Hippocampal volume; CESC cis rs9486715 0.867 rs1127175 chr6:96999725 C/T cg18709589 chr6:96969512 KIAA0776 -0.46 -6.48 -0.37 4.5e-10 Headache; CESC cis rs11997175 0.545 rs59563980 chr8:33665377 C/T ch.8.33884649F chr8:33765107 NA 0.56 7.03 0.4 1.73e-11 Body mass index; CESC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg00166722 chr3:10149974 C3orf24 0.48 6.1 0.35 3.66e-9 Alzheimer's disease; CESC cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg25554036 chr4:6271136 WFS1 0.52 8.3 0.45 5.43e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1878931 0.580 rs4785932 chr16:3410456 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.99 15.31 0.69 2.49e-38 Body mass index (adult); CESC cis rs634534 0.622 rs624273 chr11:65712413 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.57 7.36 0.41 2.31e-12 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs6088580 0.634 rs6142159 chr20:32993035 G/A cg08999081 chr20:33150536 PIGU -0.64 -11.25 -0.57 2.81e-24 Glomerular filtration rate (creatinine); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03454357 chr2:42565216 NA 0.47 6.11 0.35 3.51e-9 Fibrinogen levels; CESC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg02807482 chr3:125708958 NA -0.42 -5.89 -0.34 1.15e-8 Blood pressure (smoking interaction); CESC cis rs12541635 0.966 rs4734894 chr8:106995313 G/A cg10147462 chr8:107024639 NA 0.41 5.74 0.33 2.63e-8 Age of smoking initiation; CESC cis rs6502050 0.835 rs9674648 chr17:80096756 A/G cg23985595 chr17:80112537 CCDC57 -0.4 -6.26 -0.36 1.55e-9 Life satisfaction; CESC cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg20891283 chr12:69753455 YEATS4 0.9 15.12 0.68 1.17e-37 Blood protein levels; CESC cis rs854765 0.693 rs11657074 chr17:17770355 G/A cg09796270 chr17:17721594 SREBF1 -0.45 -6.36 -0.36 8.61e-10 Total body bone mineral density; CESC cis rs963731 0.649 rs297129 chr2:39299271 C/T cg04010122 chr2:39346883 SOS1 0.7 5.5 0.32 9.03e-8 Corticobasal degeneration; CESC cis rs8060686 0.925 rs9928531 chr16:67833171 T/C cg26727032 chr16:67993705 SLC12A4 -0.63 -9.17 -0.49 1.4e-17 HDL cholesterol;Metabolic syndrome; CESC cis rs2243480 1.000 rs316315 chr7:65591205 C/T cg12463550 chr7:65579703 CRCP -0.68 -6.2 -0.36 2.13e-9 Diabetic kidney disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00491963 chr11:57335356 UBE2L6 -0.39 -6.04 -0.35 5.07e-9 Gambling; CESC cis rs761746 0.672 rs12627933 chr22:32027449 C/T cg25791279 chr22:32026902 PISD 0.56 5.76 0.33 2.36e-8 Intelligence; CESC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg12463550 chr7:65579703 CRCP 0.55 6.87 0.39 4.52e-11 Aortic root size; CESC cis rs1018836 0.631 rs2205158 chr8:91472515 C/T cg16814680 chr8:91681699 NA -0.52 -6.92 -0.39 3.38e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs116095464 1.000 rs6555159 chr5:311562 G/A cg22857025 chr5:266934 NA -1.24 -10.85 -0.55 6.11e-23 Breast cancer; CESC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg04166393 chr7:2884313 GNA12 0.61 8.48 0.46 1.58e-15 Height; CESC cis rs28374715 0.681 rs7168307 chr15:41620534 A/G cg18705301 chr15:41695430 NDUFAF1 -0.8 -11.98 -0.59 1.03e-26 Ulcerative colitis; CESC cis rs6088580 0.561 rs3761147 chr20:32996689 G/T cg24642439 chr20:33292090 TP53INP2 -0.51 -6.67 -0.38 1.48e-10 Glomerular filtration rate (creatinine); CESC cis rs2880765 0.835 rs7168860 chr15:86037030 G/A cg19183879 chr15:85880815 NA -0.26 -5.29 -0.31 2.51e-7 Coronary artery disease; CESC cis rs2299587 0.553 rs2299580 chr8:17734567 C/A cg08627089 chr8:17753878 FGL1 -0.4 -5.73 -0.33 2.77e-8 Economic and political preferences; CESC cis rs2249694 0.960 rs6537613 chr10:135412414 T/G cg20169779 chr10:135381914 SYCE1 -0.41 -5.78 -0.33 2.12e-8 Obesity-related traits; CESC cis rs3806843 0.966 rs2337986 chr5:140160622 C/T cg26395211 chr5:140044315 WDR55 -0.42 -5.43 -0.32 1.26e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9487051 0.597 rs351731 chr6:109507842 A/T cg01475377 chr6:109611718 NA -0.39 -5.17 -0.3 4.58e-7 Reticulocyte fraction of red cells; CESC cis rs7918232 0.941 rs6482598 chr10:27426375 T/C cg14240646 chr10:27532245 ACBD5 -0.66 -6.43 -0.37 5.89e-10 Breast cancer; CESC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg04944784 chr2:26401820 FAM59B 0.96 10.5 0.54 8.76e-22 Gut microbiome composition (summer); CESC cis rs2857078 0.720 rs9901595 chr17:42305699 G/A cg19774624 chr17:42201019 HDAC5 -0.55 -7.41 -0.41 1.75e-12 Red cell distribution width;Reticulocyte count; CESC cis rs796364 0.806 rs56216998 chr2:200944333 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.82 -7.29 -0.41 3.5e-12 Schizophrenia; CESC cis rs637571 0.565 rs570387 chr11:65637076 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.71 -9.01 -0.48 4.3e-17 Eosinophil percentage of white cells; CESC cis rs1387259 0.929 rs11168484 chr12:48633589 A/C cg24011408 chr12:48396354 COL2A1 0.43 5.9 0.34 1.11e-8 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs7605827 0.930 rs6708288 chr2:15535477 A/G cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs2963155 0.518 rs864355 chr5:142633229 A/G cg17617527 chr5:142782415 NR3C1 0.84 7.49 0.42 1.06e-12 Breast cancer; CESC cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg01475377 chr6:109611718 NA 0.5 8.31 0.45 5.09e-15 Reticulocyte fraction of red cells; CESC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg04166393 chr7:2884313 GNA12 0.6 7.73 0.43 2.27e-13 Height; CESC trans rs11039798 0.528 rs10769559 chr11:49032446 T/C cg15704280 chr7:45808275 SEPT13 0.65 6.96 0.39 2.68e-11 Axial length; CESC cis rs78456975 1.000 rs11899027 chr2:1560414 G/C cg01028140 chr2:1542097 TPO -0.5 -5.37 -0.31 1.69e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs684232 0.666 rs2657629 chr17:602261 G/T cg12384639 chr17:618140 VPS53 0.41 5.45 0.32 1.15e-7 Prostate cancer; CESC trans rs10242455 0.717 rs4646461 chr7:99331473 C/T cg09045935 chr12:6379348 NA 0.65 6.05 0.35 4.85e-9 Blood metabolite levels; CESC cis rs473651 0.935 rs520765 chr2:239354712 C/T cg21699342 chr2:239360505 ASB1 0.56 9.65 0.51 4.45e-19 Multiple system atrophy; CESC cis rs7179456 0.610 rs650366 chr15:59061142 A/G cg05156742 chr15:59063176 FAM63B 0.66 8.94 0.48 6.9e-17 Asperger disorder; CESC cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7259376 0.875 rs6511345 chr19:22537436 T/C cg02657401 chr19:22469223 NA -0.26 -5.16 -0.3 4.9e-7 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24886033 chr12:10265096 NA -0.64 -7.53 -0.42 7.8e-13 Gut microbiome composition (summer); CESC cis rs7085104 0.513 rs619824 chr10:104581288 G/T cg04362960 chr10:104952993 NT5C2 0.51 6.85 0.39 5.05e-11 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs9611565 0.681 rs5751094 chr22:41803279 C/T cg06481639 chr22:41940642 POLR3H 0.62 6.52 0.37 3.49e-10 Vitiligo; CESC cis rs2295499 0.678 rs12503560 chr4:2714482 T/C cg27239842 chr4:2403781 ZFYVE28 -0.33 -5.64 -0.33 4.28e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs12107539 1.000 rs3773621 chr3:150996434 A/C cg05862518 chr17:40277425 RAB5C -0.48 -6.3 -0.36 1.22e-9 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC cis rs72945132 0.882 rs72947078 chr11:70197542 G/T cg14191688 chr11:70257035 CTTN 0.46 5.41 0.32 1.41e-7 Coronary artery disease; CESC cis rs9549367 0.737 rs9549712 chr13:113902355 G/A cg18105134 chr13:113819100 PROZ -0.68 -8.25 -0.45 7.53e-15 Platelet distribution width; CESC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg07701084 chr6:150067640 NUP43 0.44 5.95 0.34 8.59e-9 Lung cancer; CESC cis rs9859260 0.710 rs366268 chr3:195782177 A/G cg12923728 chr3:195709715 SDHAP1 0.53 6.93 0.39 3.14e-11 Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15952933 chr7:1899886 MAD1L1 0.52 7.14 0.4 8.8e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17253792 0.822 rs76555508 chr14:56071868 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs1801251 1.000 rs12987513 chr2:233622066 A/G cg25237894 chr2:233734115 C2orf82 0.44 7.63 0.42 4.32e-13 Coronary artery disease; CESC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg02725872 chr8:58115012 NA -0.44 -6.87 -0.39 4.53e-11 Developmental language disorder (linguistic errors); CESC trans rs801193 1.000 rs4717319 chr7:66242593 A/G cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg22800045 chr5:56110881 MAP3K1 0.73 7.19 0.4 6.64e-12 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04439696 chr6:36954195 MTCH1 0.61 7.48 0.42 1.08e-12 Gut microbiome composition (summer); CESC cis rs208520 1.000 rs12212063 chr6:66985148 C/A cg07460842 chr6:66804631 NA 0.77 8.92 0.48 8.09e-17 Exhaled nitric oxide output; CESC cis rs13191362 0.507 rs2846535 chr6:163034019 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.5 -6.24 -0.36 1.74e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg24675658 chr1:53192096 ZYG11B 0.54 6.8 0.39 6.96e-11 Monocyte count; CESC cis rs926938 0.527 rs1391484 chr1:115522366 A/G cg12756093 chr1:115239321 AMPD1 0.45 6.15 0.35 2.84e-9 Autism; CESC cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -5.06 -0.3 7.76e-7 Developmental language disorder (linguistic errors); CESC cis rs7267979 0.966 rs2257461 chr20:25265554 A/G cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs12824058 0.798 rs4759652 chr12:130808771 C/T cg26677194 chr12:130822605 PIWIL1 0.5 6.49 0.37 4.23e-10 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11087747 chr19:41107377 LTBP4 0.48 6.0 0.35 6.63e-9 Gut microbiota (bacterial taxa); CESC cis rs9790314 1.000 rs336583 chr3:161081981 A/T cg03342759 chr3:160939853 NMD3 0.47 5.95 0.34 8.63e-9 Morning vs. evening chronotype; CESC cis rs854765 0.547 rs2955355 chr17:17948475 G/A cg04398451 chr17:18023971 MYO15A 0.71 10.43 0.54 1.44e-21 Total body bone mineral density; CESC cis rs11997175 0.625 rs17698353 chr8:33592241 A/G ch.8.33884649F chr8:33765107 NA 0.51 6.29 0.36 1.34e-9 Body mass index; CESC cis rs2243480 1.000 rs422164 chr7:65586605 C/G cg12463550 chr7:65579703 CRCP 0.73 5.68 0.33 3.5e-8 Diabetic kidney disease; CESC cis rs2204008 0.658 rs11181310 chr12:38315963 C/A cg13010199 chr12:38710504 ALG10B 0.44 5.62 0.33 4.91e-8 Bladder cancer; CESC trans rs61931739 0.500 rs7979482 chr12:34542877 C/A cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.8e-23 Morning vs. evening chronotype; CESC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.88 0.52 8.11e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7914558 1.000 rs12255047 chr10:104760752 G/A cg15744005 chr10:104629667 AS3MT -0.34 -5.51 -0.32 8.56e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10300236 chr14:59950716 C14orf149;JKAMP 0.62 7.12 0.4 9.88e-12 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.65 0.38 1.71e-10 Prudent dietary pattern; CESC cis rs9796 0.621 rs58109657 chr15:41471750 A/G cg20272979 chr15:41787780 ITPKA -0.34 -5.18 -0.3 4.46e-7 Menopause (age at onset); CESC cis rs116095464 1.000 rs2015774 chr5:312958 G/T cg10591111 chr5:226296 SDHA -0.61 -5.68 -0.33 3.5e-8 Breast cancer; CESC cis rs11677370 0.603 rs11675498 chr2:3850943 G/T cg17052675 chr2:3827356 NA -0.43 -5.5 -0.32 8.9e-8 Type 2 diabetes; CESC cis rs6499255 0.951 rs61310815 chr16:69701239 A/T cg15192750 chr16:69999425 NA 0.45 5.23 0.31 3.53e-7 IgE levels; CESC cis rs6964587 0.869 rs2023784 chr7:91524677 A/G cg17063962 chr7:91808500 NA -0.53 -7.0 -0.39 2.11e-11 Breast cancer; CESC cis rs2953174 0.938 rs2975764 chr2:241534381 A/G cg07929629 chr2:241523174 NA 0.57 5.33 0.31 2.09e-7 Bipolar disorder; CESC cis rs9283706 0.594 rs7717020 chr5:66353322 A/C cg11590213 chr5:66331682 MAST4 0.39 5.09 0.3 6.9e-7 Coronary artery disease; CESC cis rs1372520 0.684 rs1811442 chr4:90747751 C/T cg15133208 chr4:90757351 SNCA -0.4 -5.49 -0.32 9.46e-8 Neuroticism; CESC cis rs6142102 0.580 rs4911139 chr20:32551535 G/A cg08999081 chr20:33150536 PIGU 0.33 5.04 0.3 8.7e-7 Skin pigmentation; CESC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg04772025 chr11:68637568 NA 0.55 6.49 0.37 4.17e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs921968 0.643 rs1344645 chr2:219538019 A/C cg02176678 chr2:219576539 TTLL4 0.39 6.54 0.37 3.13e-10 Mean corpuscular hemoglobin concentration; CESC cis rs8018808 0.936 rs10140302 chr14:77855693 C/A cg20045696 chr14:77926864 AHSA1 -0.38 -5.18 -0.3 4.46e-7 Myeloid white cell count; CESC cis rs11048434 0.736 rs11048195 chr12:9105923 A/G cg23795048 chr12:9217529 LOC144571 0.35 5.4 0.31 1.52e-7 Sjögren's syndrome; CESC cis rs73206853 0.619 rs112148402 chr12:111171493 T/C cg12870014 chr12:110450643 ANKRD13A 0.73 5.39 0.31 1.53e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs4642101 0.680 rs6442330 chr3:12820501 A/G cg24848339 chr3:12840334 CAND2 0.41 6.36 0.36 8.71e-10 QRS complex (12-leadsum); CESC cis rs2370759 1.000 rs16933243 chr10:32615135 T/C cg01819863 chr10:32635814 EPC1 1.16 12.49 0.61 1.86e-28 Sexual dysfunction (female); CESC cis rs2732480 0.577 rs2732481 chr12:48736985 T/G cg24011408 chr12:48396354 COL2A1 0.44 5.95 0.34 8.54e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.43 -5.73 -0.33 2.74e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9359856 0.564 rs72913954 chr6:90361589 T/C cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.7 -0.33 3.12e-8 Bipolar disorder; CESC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg09323728 chr8:95962352 TP53INP1 -0.37 -8.0 -0.44 3.92e-14 Type 2 diabetes; CESC cis rs2952156 0.959 rs2941503 chr17:37828745 A/G cg00129232 chr17:37814104 STARD3 -0.73 -9.76 -0.51 1.96e-19 Asthma; CESC cis rs7246657 0.943 rs7252099 chr19:37933780 G/A cg23950597 chr19:37808831 NA -0.61 -6.23 -0.36 1.85e-9 Coronary artery calcification; CESC cis rs13191362 1.000 rs67747005 chr6:163150845 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.69 7.11 0.4 1.11e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18132058 chr10:131567108 NA -0.55 -6.09 -0.35 4e-9 Gut microbiome composition (summer); CESC cis rs748404 0.697 rs546170 chr15:43564849 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.59 7.8 0.43 1.44e-13 Lung cancer; CESC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.75 0.38 9.1e-11 Bipolar disorder; CESC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg08736216 chr1:53307985 ZYG11A -0.34 -5.69 -0.33 3.44e-8 Monocyte count; CESC cis rs9487051 0.743 rs388526 chr6:109543425 C/G cg01475377 chr6:109611718 NA -0.37 -5.35 -0.31 1.92e-7 Reticulocyte fraction of red cells; CESC cis rs17666538 0.585 rs1669615 chr8:616665 T/C cg07234876 chr8:600039 NA 0.83 5.89 0.34 1.15e-8 IgG glycosylation; CESC cis rs2425143 0.908 rs12480111 chr20:34423186 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -6.11 -0.35 3.47e-9 Blood protein levels; CESC cis rs8016982 0.633 rs72695758 chr14:81720146 T/C cg01989461 chr14:81687754 GTF2A1 0.71 10.96 0.56 2.67e-23 Schizophrenia; CESC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg06877462 chr1:205807181 PM20D1 0.37 5.37 0.31 1.71e-7 Menarche (age at onset); CESC cis rs2860975 0.620 rs7077618 chr10:96793457 T/A cg09036531 chr10:96991505 NA -0.35 -5.08 -0.3 7.24e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs9399137 0.507 rs11154791 chr6:135379148 A/G cg22676075 chr6:135203613 NA 0.53 7.05 0.4 1.52e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.99 0.56 2.18e-23 Hip circumference adjusted for BMI; CESC cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg17724175 chr1:150552817 MCL1 -0.33 -5.23 -0.31 3.42e-7 Tonsillectomy; CESC cis rs2197308 0.765 rs7295711 chr12:37903631 C/T cg26384229 chr12:38710491 ALG10B 0.75 11.12 0.56 8.21e-24 Morning vs. evening chronotype; CESC cis rs7659604 0.540 rs13140070 chr4:122713899 C/T cg19748678 chr4:122722346 EXOSC9 -0.42 -5.26 -0.31 2.99e-7 Type 2 diabetes; CESC cis rs9611565 0.649 rs5751144 chr22:42128097 A/G cg03806693 chr22:41940476 POLR3H -0.76 -9.22 -0.49 9.9e-18 Vitiligo; CESC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg23281280 chr6:28129359 ZNF389 0.56 7.62 0.42 4.55e-13 Depression; CESC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg06221963 chr1:154839813 KCNN3 -0.67 -11.38 -0.57 1.05e-24 Prostate cancer; CESC cis rs7551222 0.752 rs16853958 chr1:204528344 A/C cg20240347 chr1:204465584 NA -0.26 -5.3 -0.31 2.45e-7 Schizophrenia; CESC cis rs854765 0.552 rs6502624 chr17:17847936 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC cis rs8053891 0.756 rs12708922 chr16:72001629 A/G cg04254540 chr16:71951199 KIAA0174 -0.41 -5.31 -0.31 2.29e-7 Coronary artery disease; CESC cis rs34779708 0.733 rs7081597 chr10:35546331 G/C cg04310649 chr10:35416472 CREM -0.46 -5.28 -0.31 2.76e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs59698941 0.943 rs67462411 chr5:132220031 C/T cg02081065 chr5:132209139 LEAP2 -0.52 -5.11 -0.3 6.08e-7 Apolipoprotein A-IV levels; CESC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg13206674 chr6:150067644 NUP43 0.41 5.94 0.34 8.98e-9 Lung cancer; CESC cis rs7116495 0.609 rs10736780 chr11:71650241 T/C cg07596299 chr11:71824057 C11orf51 -0.76 -5.21 -0.3 3.77e-7 Severe influenza A (H1N1) infection; CESC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.13 -0.3 5.73e-7 Life satisfaction; CESC cis rs763121 0.853 rs138716 chr22:39146527 C/T cg06022373 chr22:39101656 GTPBP1 0.88 13.83 0.65 4.02e-33 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04724143 chr13:114185494 TMCO3 -0.6 -6.95 -0.39 2.76e-11 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs10080225 chr5:232175 A/G cg22496380 chr5:211416 CCDC127 -0.73 -8.37 -0.46 3.25e-15 Breast cancer; CESC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg07677032 chr17:61819896 STRADA 0.49 6.59 0.38 2.42e-10 Prudent dietary pattern; CESC cis rs9611565 0.592 rs57102627 chr22:41987627 T/C cg06634786 chr22:41940651 POLR3H -0.57 -6.28 -0.36 1.35e-9 Vitiligo; CESC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg23048001 chr7:2026167 MAD1L1 -0.43 -5.57 -0.32 6.34e-8 Bipolar disorder and schizophrenia; CESC cis rs708547 0.836 rs781554 chr4:57717537 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.5 -5.42 -0.32 1.36e-7 Response to bleomycin (chromatid breaks); CESC cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg04978709 chr7:75101039 POM121C 0.48 6.91 0.39 3.5e-11 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs3942852 0.868 rs7122335 chr11:48106486 C/T cg15704280 chr7:45808275 SEPT13 -0.68 -7.45 -0.42 1.35e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.78 0.52 1.7e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1801251 1.000 rs283486 chr2:233644223 A/G cg25237894 chr2:233734115 C2orf82 0.46 8.01 0.44 3.67e-14 Coronary artery disease; CESC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.78 -0.38 7.71e-11 Electroencephalogram traits; CESC cis rs1461503 0.512 rs4293126 chr11:122804133 A/G cg27398637 chr11:122830231 C11orf63 0.49 6.9 0.39 3.83e-11 Menarche (age at onset); CESC cis rs3762318 0.756 rs6703475 chr1:67603972 T/C cg17031739 chr1:67600172 NA 0.53 5.11 0.3 6.16e-7 Leprosy; CESC cis rs7100689 0.725 rs2487074 chr10:82064104 A/G cg00277334 chr10:82204260 NA -0.57 -7.14 -0.4 8.97e-12 Post bronchodilator FEV1; CESC cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg09455208 chr3:40491958 NA -0.48 -8.01 -0.44 3.6e-14 Renal cell carcinoma; CESC cis rs1401999 0.510 rs3749438 chr3:183705184 G/A cg01324343 chr3:183735012 ABCC5 0.36 6.15 0.35 2.77e-9 Anterior chamber depth; CESC cis rs1670533 1.000 rs7673898 chr4:1056569 C/A cg27284194 chr4:1044797 NA 0.48 6.06 0.35 4.7e-9 Recombination rate (females); CESC cis rs35306767 0.903 rs765867 chr10:869901 G/T cg20503657 chr10:835505 NA 0.82 8.27 0.45 6.52e-15 Eosinophil percentage of granulocytes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06518779 chr13:103452556 BIVM;KDELC1 0.5 6.39 0.37 7.63e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs965469 0.817 rs6037582 chr20:3351696 C/T cg25506879 chr20:3388711 C20orf194 -0.49 -5.24 -0.31 3.22e-7 IFN-related cytopenia; CESC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg24562669 chr7:97807699 LMTK2 0.48 6.95 0.39 2.81e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg27572855 chr1:25598939 RHD 0.42 6.98 0.39 2.43e-11 Erythrocyte sedimentation rate; CESC cis rs864537 0.676 rs3108155 chr1:167422057 C/G cg22356347 chr1:167427500 CD247 -0.39 -8.02 -0.44 3.48e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs12079745 0.793 rs60011235 chr1:169254727 T/C cg09363564 chr1:169337483 NME7;BLZF1 -0.94 -6.2 -0.36 2.13e-9 QT interval; CESC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg13206674 chr6:150067644 NUP43 0.43 6.05 0.35 4.94e-9 Lung cancer; CESC trans rs9325144 0.555 rs1825806 chr12:38692547 G/A cg23762105 chr12:34175262 ALG10 -0.49 -6.56 -0.37 2.76e-10 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14843989 chr17:10600751 C17orf48;SCO1 -0.43 -6.11 -0.35 3.59e-9 Fibrinogen levels; CESC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg13206674 chr6:150067644 NUP43 0.42 5.89 0.34 1.19e-8 Lung cancer; CESC cis rs2777491 0.522 rs7169278 chr15:41696932 A/G cg18705301 chr15:41695430 NDUFAF1 -0.56 -7.77 -0.43 1.72e-13 Ulcerative colitis; CESC cis rs12530845 0.887 rs79100776 chr7:135315817 G/A cg23117316 chr7:135346802 PL-5283 -0.48 -5.83 -0.34 1.58e-8 Red blood cell traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01688141 chr8:23539808 NKX3-1 0.49 6.27 0.36 1.48e-9 Gut microbiota (bacterial taxa); CESC trans rs4950322 0.563 rs6700783 chr1:146583569 A/T cg04954894 chr8:38089920 DDHD2 -0.58 -6.34 -0.36 9.9e-10 Protein quantitative trait loci; CESC cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.34 0.31 1.98e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10479542 0.929 rs10078796 chr5:178978883 T/A cg05457628 chr5:178986728 RUFY1 0.51 7.69 0.43 2.8e-13 Lung cancer; CESC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.7 0.64 1.15e-32 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10212537 chr14:93799559 BTBD7;KIAA1409 0.72 8.54 0.46 1.1e-15 Gut microbiome composition (summer); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg18030105 chr11:3396237 ZNF195 -0.48 -6.51 -0.37 3.75e-10 Breast cancer;Type 2 diabetes; CESC cis rs2303759 0.676 rs7248378 chr19:49908144 C/A cg24324837 chr19:49891574 CCDC155 0.43 5.04 0.3 8.53e-7 Multiple sclerosis; CESC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg23758822 chr17:41437982 NA -1.06 -16.29 -0.71 8.49e-42 Menopause (age at onset); CESC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.26 0.31 3e-7 Menopause (age at onset); CESC cis rs11247915 0.583 rs66569416 chr1:26659737 C/G cg04990556 chr1:26633338 UBXN11 -0.58 -6.53 -0.37 3.33e-10 Obesity-related traits; CESC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg01416388 chr22:39784598 NA 0.56 6.84 0.39 5.46e-11 Intelligence (multi-trait analysis); CESC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg02951883 chr7:2050386 MAD1L1 -0.46 -5.85 -0.34 1.47e-8 Bipolar disorder and schizophrenia; CESC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 6.0 0.35 6.28e-9 Electroencephalogram traits; CESC cis rs11630290 0.592 rs12324668 chr15:64161786 A/T cg12036633 chr15:63758958 NA 0.44 5.32 0.31 2.2e-7 Iris characteristics; CESC cis rs10493773 0.609 rs11161656 chr1:86182414 A/G cg17807903 chr1:86174739 ZNHIT6 -0.44 -6.53 -0.37 3.43e-10 Urate levels in overweight individuals; CESC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg03806693 chr22:41940476 POLR3H -1.19 -13.81 -0.65 4.89e-33 Vitiligo; CESC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg16049864 chr8:95962084 TP53INP1 -0.65 -11.35 -0.57 1.31e-24 Type 2 diabetes; CESC cis rs897080 0.552 rs1067318 chr2:44634509 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs9911578 1.000 rs2531734 chr17:56550804 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.52 -0.32 7.9e-8 Intelligence (multi-trait analysis); CESC cis rs11166629 1.000 rs7003870 chr8:135616586 A/G cg27224718 chr8:135614730 ZFAT 0.5 6.27 0.36 1.5e-9 Smoking quantity; CESC cis rs2404602 0.647 rs12910081 chr15:77022959 G/C cg23625390 chr15:77176239 SCAPER -0.46 -6.5 -0.37 4.05e-10 Blood metabolite levels; CESC cis rs7072216 0.763 rs10883090 chr10:100167236 G/C cg26618903 chr10:100175079 PYROXD2 -0.37 -5.54 -0.32 7.25e-8 Metabolite levels; CESC cis rs947211 0.950 rs885224 chr1:205753097 A/G cg26354017 chr1:205819088 PM20D1 0.42 5.32 0.31 2.25e-7 Parkinson's disease; CESC cis rs4835473 0.868 rs7683365 chr4:144920596 G/A cg25736465 chr4:144833511 NA -0.46 -6.94 -0.39 2.96e-11 Immature fraction of reticulocytes; CESC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.95 14.07 0.65 5.76e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11608355 0.515 rs1045263 chr12:109974191 A/G cg05360138 chr12:110035743 NA 0.81 8.77 0.47 2.28e-16 Neuroticism; CESC trans rs116095464 0.614 rs62344292 chr5:244630 G/A cg00938859 chr5:1591904 SDHAP3 0.64 6.98 0.39 2.36e-11 Breast cancer; CESC cis rs67478160 0.679 rs8011109 chr14:104279974 G/A cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.08 -0.4 1.33e-11 Schizophrenia; CESC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.52 7.77 0.43 1.71e-13 Bipolar disorder; CESC cis rs2806561 0.704 rs2806570 chr1:23527005 C/T cg12483005 chr1:23474871 LUZP1 -0.42 -6.44 -0.37 5.46e-10 Height; CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.39 -5.65 -0.33 4.12e-8 Electroencephalogram traits; CESC cis rs2066819 1.000 rs2371494 chr12:56728000 G/A cg26734620 chr12:56694298 CS 0.9 9.04 0.49 3.32e-17 Psoriasis vulgaris; CESC cis rs3768617 0.510 rs1413387 chr1:183096774 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.4 0.64 1.29e-31 Fuchs's corneal dystrophy; CESC cis rs3768617 0.811 rs12138053 chr1:182979560 C/T ch.1.3577855R chr1:183094577 LAMC1 0.67 9.18 0.49 1.24e-17 Fuchs's corneal dystrophy; CESC cis rs7577696 0.597 rs212690 chr2:32437631 C/G cg02381751 chr2:32503542 YIPF4 0.48 5.37 0.31 1.72e-7 Inflammatory biomarkers; CESC trans rs338389 0.934 rs338404 chr15:68251675 T/C cg10595952 chr5:2097052 NA -0.36 -6.03 -0.35 5.34e-9 Survival in rectal cancer; CESC cis rs870825 0.550 rs10000507 chr4:185619281 C/T cg04058563 chr4:185651563 MLF1IP 0.63 7.0 0.4 2.06e-11 Blood protein levels; CESC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg25517755 chr10:38738941 LOC399744 -0.49 -6.38 -0.37 7.75e-10 Extrinsic epigenetic age acceleration; CESC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg04315214 chr1:2043799 PRKCZ 0.52 8.83 0.48 1.47e-16 Height; CESC trans rs4335177 0.963 rs6477533 chr9:109364579 C/T cg12580783 chr12:49362475 WNT10B 0.35 6.58 0.37 2.52e-10 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs3008870 1.000 rs2182143 chr1:67378936 T/C cg02640540 chr1:67518911 SLC35D1 0.49 5.21 0.3 3.81e-7 Lymphocyte percentage of white cells; CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg22143856 chr6:28129313 ZNF389 0.49 6.22 0.36 1.9e-9 Depression; CESC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg18876405 chr7:65276391 NA 0.5 6.66 0.38 1.61e-10 Aortic root size; CESC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg21782813 chr7:2030301 MAD1L1 0.39 5.44 0.32 1.22e-7 Bipolar disorder and schizophrenia; CESC cis rs2235544 0.542 rs585269 chr1:54469976 C/T cg25741118 chr1:54482237 LDLRAD1 0.24 5.76 0.33 2.29e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs2760061 0.626 rs2527615 chr1:228119283 A/G cg02753203 chr1:228287806 NA -0.5 -7.34 -0.41 2.69e-12 Diastolic blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01042287 chr16:28884343 SH2B1 0.45 6.27 0.36 1.45e-9 Fibrinogen levels; CESC cis rs9815354 0.812 rs17218504 chr3:41987278 A/G cg03022575 chr3:42003672 ULK4 0.68 6.1 0.35 3.75e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs854765 0.522 rs63721860 chr17:17829576 T/C cg16928487 chr17:17741425 SREBF1 -0.53 -8.83 -0.48 1.5e-16 Total body bone mineral density; CESC cis rs6912958 0.559 rs242280 chr6:88048714 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.44 7.8 0.43 1.47e-13 Monocyte percentage of white cells; CESC cis rs9858542 0.953 rs3811699 chr3:49396360 T/C cg07274523 chr3:49395745 GPX1 0.67 8.38 0.46 3.13e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2370759 1.000 rs78959390 chr10:32616346 C/T cg18270830 chr10:32634957 EPC1 0.71 6.78 0.38 7.78e-11 Sexual dysfunction (female); CESC cis rs1190552 0.846 rs12883789 chr14:102954621 G/A cg18135206 chr14:102964638 TECPR2 0.42 5.27 0.31 2.84e-7 Blood protein levels; CESC cis rs4808199 0.901 rs11669516 chr19:19532682 G/A cg03709012 chr19:19516395 GATAD2A 1.12 13.53 0.64 4.5e-32 Nonalcoholic fatty liver disease; CESC cis rs2243480 1.000 rs13220979 chr7:65363204 G/A cg18252515 chr7:66147081 NA -1.01 -9.32 -0.5 4.6e-18 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11446193 chr11:57405815 NA -0.53 -6.15 -0.35 2.82e-9 Gut microbiome composition (summer); CESC cis rs7474896 0.583 rs10827818 chr10:38000856 T/C cg00409905 chr10:38381863 ZNF37A -0.48 -5.59 -0.32 5.65e-8 Obesity (extreme); CESC cis rs12190007 0.508 rs9406321 chr6:169726841 A/T cg16388071 chr6:169726476 NA 0.56 8.21 0.45 9.58e-15 Obesity-related traits; CESC cis rs9300255 0.722 rs1060105 chr12:123806219 C/T cg00376283 chr12:123451042 ABCB9 -0.59 -6.26 -0.36 1.51e-9 Neutrophil percentage of white cells; CESC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg12463550 chr7:65579703 CRCP 0.59 7.45 0.42 1.29e-12 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03839252 chr13:41240923 FOXO1 0.54 6.07 0.35 4.35e-9 Gut microbiome composition (summer); CESC cis rs25645 0.830 rs3935281 chr17:38188419 C/T cg17467752 chr17:38218738 THRA -0.51 -6.65 -0.38 1.63e-10 Myeloid white cell count; CESC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg07936489 chr17:37558343 FBXL20 0.78 11.12 0.56 7.9e-24 Glomerular filtration rate (creatinine); CESC cis rs11792861 0.781 rs28361106 chr9:111762385 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -5.4 -0.31 1.51e-7 Menarche (age at onset); CESC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg25036284 chr2:26402008 FAM59B -0.6 -6.93 -0.39 3.12e-11 Gut microbiome composition (summer); CESC cis rs1005277 0.540 rs1814077 chr10:37992018 G/C cg00409905 chr10:38381863 ZNF37A -0.52 -7.09 -0.4 1.23e-11 Extrinsic epigenetic age acceleration; CESC cis rs6933660 0.800 rs3800273 chr6:151759035 G/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.48 -6.22 -0.36 1.95e-9 Menarche (age at onset); CESC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg09060608 chr5:178986726 RUFY1 -0.56 -8.79 -0.48 1.95e-16 Lung cancer; CESC cis rs7078219 0.543 rs10786557 chr10:101283328 C/G cg09788492 chr10:101292477 NKX2-3 0.31 5.9 0.34 1.12e-8 Dental caries; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05553000 chr11:121163394 SC5DL -0.45 -6.05 -0.35 5.05e-9 Fibrinogen levels; CESC cis rs11025559 0.716 rs1596376 chr11:20454229 T/C cg19653624 chr11:20408972 PRMT3 -0.44 -5.08 -0.3 7.14e-7 Pursuit maintenance gain; CESC cis rs17376456 1.000 rs34854140 chr5:93538169 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.21 0.3 3.8e-7 Diabetic retinopathy; CESC cis rs10178094 0.528 rs62175963 chr2:161339964 T/C cg03641300 chr2:160917029 PLA2R1 -0.48 -6.25 -0.36 1.65e-9 White blood cell count; CESC cis rs7202877 0.561 rs7202083 chr16:75383727 G/T cg04384234 chr16:75411784 CFDP1 -0.56 -5.63 -0.33 4.68e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg05215748 chr17:6898738 ALOX12 0.33 6.8 0.39 7.08e-11 Tonsillectomy; CESC cis rs10794720 0.867 rs78029387 chr10:1138589 C/T cg08668510 chr10:1095578 IDI1 0.96 5.71 0.33 3.03e-8 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease; CESC cis rs3015469 0.671 rs35313842 chr14:51217893 C/T cg26011998 chr14:51135199 SAV1 0.51 5.89 0.34 1.14e-8 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.21 0.36 2.06e-9 Cystic fibrosis severity; CESC cis rs208520 0.690 rs207107 chr6:66794385 T/C cg07460842 chr6:66804631 NA -1.0 -13.33 -0.63 2.21e-31 Exhaled nitric oxide output; CESC cis rs10876993 0.928 rs1689595 chr12:58056763 C/T cg18357645 chr12:58087776 OS9 0.64 10.33 0.54 2.96e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs2797160 1.000 rs6904069 chr6:125995134 C/T cg05901451 chr6:126070800 HEY2 -0.46 -6.63 -0.38 1.87e-10 Endometrial cancer; CESC cis rs6426558 0.502 rs1929858 chr1:227220175 C/A cg10327440 chr1:227177885 CDC42BPA 0.52 6.31 0.36 1.15e-9 Neutrophil percentage of white cells; CESC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg19774624 chr17:42201019 HDAC5 0.69 10.08 0.53 2e-20 Total body bone mineral density; CESC trans rs10841784 0.958 rs7962263 chr12:21466117 A/G cg21964798 chr5:1503259 LPCAT1 0.53 6.49 0.37 4.23e-10 Childhood ear infection; CESC cis rs17253792 0.822 rs79747476 chr14:56160485 C/A cg01858014 chr14:56050164 KTN1 -0.97 -7.53 -0.42 8.03e-13 Putamen volume; CESC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg07507251 chr3:52567010 NT5DC2 0.47 8.73 0.47 2.88e-16 Electroencephalogram traits; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06866400 chr6:143771904 ADAT2;PEX3 -0.5 -6.5 -0.37 4.02e-10 Ulcerative colitis; CESC trans rs4824093 0.610 rs58671506 chr22:50288983 G/A cg09872104 chr7:134855509 C7orf49 -0.94 -6.17 -0.35 2.52e-9 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg13733410 chr7:12443478 VWDE -0.53 -5.45 -0.32 1.17e-7 Coronary artery disease; CESC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09395855 chr10:120967408 GRK5 0.55 6.14 0.35 2.97e-9 Gut microbiome composition (summer); CESC cis rs2280018 0.581 rs7404524 chr16:15129158 A/G cg27102117 chr16:15229624 NA 0.51 7.8 0.43 1.47e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg06627628 chr2:24431161 ITSN2 -0.64 -5.96 -0.34 8.16e-9 Lymphocyte counts; CESC cis rs13427251 0.903 rs6746402 chr2:100150443 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -5.29 -0.31 2.55e-7 Chronic sinus infection; CESC cis rs7267979 1.000 rs404394 chr20:25447896 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.57 0.73 2.33e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg03467027 chr4:99064603 C4orf37 0.42 5.32 0.31 2.25e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6912958 1.000 rs6912958 chr6:88133315 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.41 -6.7 -0.38 1.21e-10 Monocyte percentage of white cells; CESC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg20999797 chr1:1681921 NA 0.27 5.23 0.31 3.43e-7 Body mass index; CESC cis rs6460942 0.915 rs62447638 chr7:12484667 G/A cg10578991 chr7:12443926 VWDE -0.48 -5.13 -0.3 5.72e-7 Coronary artery disease; CESC cis rs3026101 0.671 rs9789012 chr17:5301070 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg21918786 chr6:109611834 NA -0.41 -6.19 -0.36 2.25e-9 Reticulocyte fraction of red cells; CESC trans rs1814175 0.645 rs11040702 chr11:50024827 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -6.13 -0.35 3.1e-9 Height; CESC cis rs2073499 0.872 rs58051625 chr3:50278717 G/C cg05260129 chr3:50388622 TUSC4;CYB561D2 0.71 5.55 0.32 6.99e-8 Schizophrenia; CESC cis rs10463316 0.608 rs13360453 chr5:150769143 T/C cg03212797 chr5:150827313 SLC36A1 -0.45 -5.88 -0.34 1.23e-8 Metabolite levels (Pyroglutamine); CESC cis rs9549260 0.753 rs9532562 chr13:41153585 A/G cg21288729 chr13:41239152 FOXO1 0.49 5.05 0.3 8.38e-7 Red blood cell count; CESC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.11 -0.3 6.3e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27659478 chr17:73891062 TRIM65 -0.53 -6.29 -0.36 1.3e-9 Gut microbiome composition (summer); CESC cis rs17486696 0.510 rs10009649 chr4:165682980 A/G cg01215651 chr4:165675138 NA 0.55 6.1 0.35 3.71e-9 Positive affect; CESC cis rs11190604 1.000 rs4919469 chr10:102298855 C/A cg07080220 chr10:102295463 HIF1AN 0.68 6.27 0.36 1.44e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs760805 0.965 rs11249203 chr1:25258585 G/C cg22509179 chr1:25234806 RUNX3 -0.6 -8.56 -0.47 9.31e-16 Allergic disease (asthma, hay fever or eczema); CESC cis rs9902453 0.933 rs8080343 chr17:28456758 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.6 0.42 5.23e-13 Coffee consumption (cups per day); CESC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg16405210 chr4:1374714 KIAA1530 -0.5 -6.26 -0.36 1.58e-9 Obesity-related traits; CESC cis rs9398803 0.723 rs853973 chr6:127068347 A/G cg19875578 chr6:126661172 C6orf173 -0.42 -5.79 -0.34 2e-8 Male-pattern baldness; CESC cis rs3820068 0.581 rs16851876 chr1:15950628 A/T cg16988262 chr1:15930761 NA -0.32 -5.21 -0.31 3.73e-7 Systolic blood pressure; CESC cis rs12477438 0.798 rs1530996 chr2:99584079 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -10.68 -0.55 2.27e-22 Chronic sinus infection; CESC cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.77 11.43 0.57 7.09e-25 Monocyte percentage of white cells; CESC cis rs2481665 0.510 rs2481676 chr1:62627675 C/T cg18591186 chr1:62594603 INADL -0.61 -8.34 -0.46 4.03e-15 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Depression; CESC cis rs2408955 0.504 rs11168441 chr12:48576054 G/A cg24011408 chr12:48396354 COL2A1 0.5 7.34 0.41 2.66e-12 Glycated hemoglobin levels; CESC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.76 -0.33 2.29e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7552404 0.696 rs10518521 chr1:76461214 G/A cg10523679 chr1:76189770 ACADM 0.65 5.93 0.34 9.48e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1153858 0.887 rs7164139 chr15:45670851 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs6061231 1.000 rs6061231 chr20:60956917 C/A cg06197360 chr20:60970103 CABLES2 -0.41 -5.23 -0.31 3.49e-7 Colorectal cancer; CESC cis rs3747547 1.000 rs55979334 chr9:37934702 T/A cg13774184 chr9:37916125 SHB -0.7 -6.07 -0.35 4.46e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.64 -0.51 4.86e-19 Alzheimer's disease; CESC cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg06027949 chr8:82754900 SNX16 -0.44 -5.24 -0.31 3.35e-7 Diastolic blood pressure; CESC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg11301795 chr4:187892539 NA -0.75 -12.37 -0.61 4.63e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs11792861 0.890 rs3750465 chr9:111900677 T/C cg13535736 chr9:111863775 C9orf5 -0.5 -6.61 -0.38 2.12e-10 Menarche (age at onset); CESC cis rs3820068 0.705 rs74054769 chr1:15860147 A/C cg17385448 chr1:15911702 AGMAT 0.38 5.86 0.34 1.37e-8 Systolic blood pressure; CESC cis rs12586317 0.547 rs2273154 chr14:35433187 C/T cg05294307 chr14:35346193 BAZ1A -0.5 -5.36 -0.31 1.81e-7 Psoriasis; CESC cis rs11048434 0.636 rs12815310 chr12:9059934 A/G cg23795048 chr12:9217529 LOC144571 0.32 5.06 0.3 7.96e-7 Sjögren's syndrome; CESC cis rs116095464 0.619 rs2303741 chr5:218356 T/C cg22496380 chr5:211416 CCDC127 -0.72 -8.57 -0.47 8.59e-16 Breast cancer; CESC cis rs7772486 0.754 rs9386133 chr6:146141213 A/G cg05347473 chr6:146136440 FBXO30 0.47 6.07 0.35 4.37e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg22638593 chr5:131593259 PDLIM4 0.41 5.33 0.31 2.07e-7 Breast cancer; CESC cis rs4924935 0.851 rs17743944 chr17:18809268 A/G cg26378065 chr17:18585709 ZNF286B -0.51 -5.83 -0.34 1.61e-8 Pancreatic cancer; CESC cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4964805 0.581 rs7312825 chr12:104188388 G/C cg02344784 chr12:104178138 NT5DC3 0.46 6.57 0.37 2.73e-10 Attention deficit hyperactivity disorder; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg05924733 chr4:160277162 RAPGEF2 0.42 6.25 0.36 1.64e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4523957 0.671 rs7223161 chr17:2176181 G/A cg16513277 chr17:2031491 SMG6 -0.44 -5.06 -0.3 7.84e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6840258 1.000 rs7695426 chr4:87921277 C/T cg08197287 chr4:87952173 AFF1 -0.42 -5.66 -0.33 3.97e-8 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.7 0.33 3.27e-8 Bipolar disorder; CESC cis rs11997175 0.574 rs4370495 chr8:33654819 G/A ch.8.33884649F chr8:33765107 NA 0.66 8.38 0.46 3.14e-15 Body mass index; CESC cis rs208520 1.000 rs12190316 chr6:66973365 T/C cg07460842 chr6:66804631 NA 0.75 8.7 0.47 3.46e-16 Exhaled nitric oxide output; CESC trans rs17307778 0.908 rs10767364 chr11:25358079 T/G cg22888484 chr20:37075185 SNHG11 -0.63 -6.07 -0.35 4.42e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs796364 0.806 rs6435041 chr2:200867144 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 7.55 0.42 7.19e-13 Schizophrenia; CESC cis rs67460515 0.892 rs7647374 chr3:160975576 T/A cg03342759 chr3:160939853 NMD3 -0.54 -7.73 -0.43 2.18e-13 Parkinson's disease; CESC cis rs2204008 0.687 rs1733404 chr12:38123395 G/T cg13010199 chr12:38710504 ALG10B -0.5 -6.16 -0.35 2.73e-9 Bladder cancer; CESC cis rs62229266 0.771 rs62230790 chr21:37388911 A/G cg12218747 chr21:37451666 NA -0.44 -6.15 -0.35 2.9e-9 Mitral valve prolapse; CESC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg23172400 chr8:95962367 TP53INP1 -0.45 -9.25 -0.49 8.02e-18 Type 2 diabetes; CESC cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.61 0.47 6.71e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.768 rs9398188 chr6:109526615 G/A cg01475377 chr6:109611718 NA -0.44 -6.67 -0.38 1.45e-10 Reticulocyte fraction of red cells; CESC cis rs7829975 0.514 rs2976929 chr8:8258712 T/C cg06636001 chr8:8085503 FLJ10661 0.5 6.65 0.38 1.67e-10 Mood instability; CESC cis rs1707322 1.000 rs4660889 chr1:46297331 C/T cg03146154 chr1:46216737 IPP 0.72 9.85 0.52 1.01e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00455883 chr3:73046007 PPP4R2 0.56 7.2 0.4 6.14e-12 Gut microbiome composition (summer); CESC cis rs9818758 0.607 rs3923475 chr3:49055788 G/T cg00383909 chr3:49044727 WDR6 0.93 6.42 0.37 6.1e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg04772025 chr11:68637568 NA 0.55 6.49 0.37 4.17e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01628954 chr18:60190696 ZCCHC2 0.47 6.02 0.35 5.85e-9 Gut microbiota (bacterial taxa); CESC trans rs561341 0.941 rs72825736 chr17:30330286 G/A cg20587970 chr11:113659929 NA -1.43 -18.64 -0.75 3.98e-50 Hip circumference adjusted for BMI; CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg18099408 chr3:52552593 STAB1 -0.34 -6.2 -0.36 2.18e-9 Bipolar disorder; CESC cis rs1348850 0.958 rs4893965 chr2:178463852 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.62 0.47 6.11e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs79349575 0.783 rs17635252 chr17:47006950 T/C cg26022315 chr17:47021804 SNF8 0.38 5.11 0.3 6.3e-7 Type 2 diabetes; CESC cis rs2996428 0.667 rs11576900 chr1:3770914 A/G cg23277830 chr1:3704460 LRRC47 0.35 5.21 0.3 3.85e-7 Red cell distribution width; CESC cis rs365132 1.000 rs2292256 chr5:176333126 C/T cg16309518 chr5:176445507 NA -0.41 -6.02 -0.35 5.71e-9 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs4604732 0.642 rs4489599 chr1:247635213 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.43 -6.41 -0.37 6.61e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9583531 0.509 rs9521923 chr13:111405462 C/T cg24331049 chr13:111365604 ING1 -0.74 -7.05 -0.4 1.53e-11 Coronary artery disease; CESC cis rs5758659 0.652 rs1063392 chr22:42454950 C/T cg05082376 chr22:42548792 NA 0.36 5.31 0.31 2.3e-7 Cognitive function; CESC cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg16339924 chr4:17578868 LAP3 0.51 6.45 0.37 5.25e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6087990 0.735 rs2424928 chr20:31388636 T/C cg13636640 chr20:31349939 DNMT3B 0.79 12.91 0.62 6.71e-30 Ulcerative colitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23426587 chr9:21335126 KLHL9 -0.44 -6.35 -0.36 9.19e-10 Gambling; CESC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.64 -0.33 4.33e-8 Total body bone mineral density; CESC cis rs933688 0.877 rs1477349 chr5:90707773 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.82 0.59 3.43e-26 Smoking behavior; CESC cis rs1707322 0.752 rs8179296 chr1:46143791 G/A cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.26 -0.36 1.54e-9 Total body bone mineral density; CESC cis rs7944584 0.588 rs2697923 chr11:47363215 G/T cg20307385 chr11:47447363 PSMC3 -0.61 -7.45 -0.42 1.31e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs1707322 1.000 rs785507 chr1:46541558 C/T cg06784218 chr1:46089804 CCDC17 -0.35 -5.85 -0.34 1.43e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7917772 0.503 rs11191328 chr10:104305185 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.54 0.42 7.69e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs208520 0.690 rs9345764 chr6:66820597 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -13.01 -0.62 3.07e-30 Exhaled nitric oxide output; CESC cis rs10911232 0.507 rs4651138 chr1:183001312 C/A ch.1.3577855R chr1:183094577 LAMC1 0.85 13.24 0.63 4.51e-31 Hypertriglyceridemia; CESC cis rs796364 0.806 rs1509832 chr2:200874443 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.84 7.71 0.43 2.62e-13 Schizophrenia; CESC cis rs763121 0.853 rs2281019 chr22:39064378 T/A cg14440974 chr22:39074834 NA -0.42 -5.82 -0.34 1.69e-8 Menopause (age at onset); CESC cis rs7412746 0.611 rs3768018 chr1:150723747 T/C cg09365446 chr1:150670422 GOLPH3L 0.39 5.16 0.3 4.94e-7 Melanoma; CESC cis rs1707322 0.927 rs11211194 chr1:46282084 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.75 0.33 2.42e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8072100 0.817 rs6505049 chr17:45675781 G/A cg08085267 chr17:45401833 C17orf57 0.44 5.57 0.32 6.39e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2273669 0.667 rs7766248 chr6:109347262 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs2274273 0.662 rs67958555 chr14:55670866 G/A cg04306507 chr14:55594613 LGALS3 0.31 5.24 0.31 3.34e-7 Protein biomarker; CESC cis rs7100689 0.646 rs4601708 chr10:82119583 G/T cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs11676348 0.818 rs4674256 chr2:218987893 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.03 -0.35 5.37e-9 Ulcerative colitis; CESC cis rs2455799 0.573 rs2062824 chr3:15757901 T/C cg16303742 chr3:15540471 COLQ -0.39 -6.07 -0.35 4.32e-9 Mean platelet volume; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08744727 chr4:206112 ZNF876P -0.53 -6.67 -0.38 1.44e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.09 0.56 9.7e-24 Alzheimer's disease; CESC cis rs11252926 0.624 rs7085214 chr10:468133 A/G cg16386425 chr10:429943 DIP2C -0.46 -5.81 -0.34 1.77e-8 Psychosis in Alzheimer's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14223017 chr19:2151266 AP3D1 -0.47 -6.12 -0.35 3.28e-9 Ulcerative colitis; CESC cis rs897984 0.542 rs7199949 chr16:31096164 G/C cg02466173 chr16:30829666 NA -0.4 -6.75 -0.38 9.46e-11 Dementia with Lewy bodies; CESC cis rs7592578 0.581 rs59109438 chr2:191287683 A/G cg10560079 chr2:191398806 TMEM194B -0.6 -5.99 -0.35 6.83e-9 Diastolic blood pressure; CESC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg24829409 chr8:58192753 C8orf71 -0.74 -9.71 -0.51 2.79e-19 Developmental language disorder (linguistic errors); CESC cis rs7124681 0.584 rs4752792 chr11:47815702 G/A cg20307385 chr11:47447363 PSMC3 -0.58 -8.03 -0.44 3.12e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs2952156 0.883 rs907088 chr17:37833567 G/C cg00129232 chr17:37814104 STARD3 -0.73 -10.44 -0.54 1.34e-21 Asthma; CESC cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg03684893 chr10:554711 DIP2C -0.35 -5.1 -0.3 6.43e-7 Psychosis in Alzheimer's disease; CESC cis rs4243830 0.850 rs2274553 chr1:6586553 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -8.69 -0.47 3.75e-16 Body mass index; CESC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg24562669 chr7:97807699 LMTK2 0.51 7.51 0.42 9.2e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs561341 1.000 rs542132 chr17:30307193 A/T cg19193384 chr17:30244184 NA -0.67 -6.36 -0.36 8.74e-10 Hip circumference adjusted for BMI; CESC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg18337363 chr3:52569053 NT5DC2 0.29 5.06 0.3 7.91e-7 Bipolar disorder; CESC cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 9.89 0.52 7.9e-20 Hip circumference adjusted for BMI; CESC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.17 0.3 4.65e-7 Electroencephalogram traits; CESC cis rs1124376 1.000 rs4417886 chr3:20108511 C/T cg05072819 chr3:20081367 KAT2B 0.62 6.51 0.37 3.68e-10 Bipolar disorder and schizophrenia; CESC cis rs2243480 1.000 rs36068983 chr7:65408991 C/T cg25894440 chr7:65020034 NA -0.59 -5.07 -0.3 7.57e-7 Diabetic kidney disease; CESC cis rs4077515 0.934 rs3829111 chr9:139269483 G/A cg14169450 chr9:139327907 INPP5E 0.36 5.27 0.31 2.85e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg14440974 chr22:39074834 NA -0.42 -5.77 -0.33 2.19e-8 Menopause (age at onset); CESC cis rs68170813 0.559 rs11769527 chr7:106912948 C/T cg02696742 chr7:106810147 HBP1 -0.52 -5.09 -0.3 6.84e-7 Coronary artery disease; CESC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg13114125 chr14:105738426 BRF1 -0.8 -9.69 -0.51 3.44e-19 Mean platelet volume;Platelet distribution width; CESC cis rs380904 0.926 rs7842979 chr8:144601896 T/G cg20583945 chr8:144636462 GSDMD 0.41 5.33 0.31 2.07e-7 Venous thromboembolism (SNP x SNP interaction); CESC cis rs9399135 0.660 rs9376072 chr6:135280519 G/C cg24558204 chr6:135376177 HBS1L 0.54 7.62 0.42 4.64e-13 Red blood cell count; CESC cis rs4132509 0.592 rs12076373 chr1:243851947 G/C cg21452805 chr1:244014465 NA 0.51 5.78 0.33 2.07e-8 RR interval (heart rate); CESC cis rs17376456 0.877 rs67066109 chr5:93494101 G/C cg25358565 chr5:93447407 FAM172A 1.18 11.54 0.58 3.22e-25 Diabetic retinopathy; CESC cis rs4561483 0.801 rs33640 chr16:11986874 C/T cg08843971 chr16:11963173 GSPT1 -0.55 -8.27 -0.45 6.52e-15 Testicular germ cell tumor; CESC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg13206674 chr6:150067644 NUP43 0.46 6.59 0.38 2.43e-10 Lung cancer; CESC cis rs72781680 1.000 rs72781634 chr2:24199102 C/T cg08917208 chr2:24149416 ATAD2B 0.9 8.12 0.45 1.8e-14 Lymphocyte counts; CESC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg11766577 chr21:47581405 C21orf56 0.46 6.35 0.36 9.51e-10 Testicular germ cell tumor; CESC cis rs66530629 0.874 rs10903104 chr1:25136713 A/G cg22509179 chr1:25234806 RUNX3 -0.43 -5.47 -0.32 1.05e-7 Plateletcrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21694044 chr22:41215540 SLC25A17 0.6 6.79 0.38 7.39e-11 Gut microbiome composition (summer); CESC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg04369109 chr6:150039330 LATS1 -0.43 -6.19 -0.36 2.31e-9 Lung cancer; CESC cis rs9297145 0.724 rs6958790 chr7:98774738 C/T cg05967295 chr7:98741636 SMURF1 -0.84 -8.7 -0.47 3.61e-16 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs7772486 0.875 rs1125461 chr6:146417653 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.43 0.37 6.04e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10129255 0.500 rs10143242 chr14:107137831 C/T cg23076370 chr14:107095027 NA -0.63 -9.58 -0.51 7.37e-19 Kawasaki disease; CESC cis rs116095464 0.558 rs62346526 chr5:220614 T/C cg10591111 chr5:226296 SDHA -0.51 -6.35 -0.36 9.22e-10 Breast cancer; CESC trans rs7726839 0.561 rs4957048 chr5:583442 G/A cg25482853 chr8:67687455 SGK3 0.88 9.24 0.49 8.24e-18 Obesity-related traits; CESC cis rs9911578 1.000 rs2643119 chr17:56827760 G/T cg12560992 chr17:57184187 TRIM37 0.92 15.09 0.68 1.43e-37 Intelligence (multi-trait analysis); CESC cis rs9325144 0.560 rs1601745 chr12:38647828 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.11 -0.35 3.56e-9 Morning vs. evening chronotype; CESC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg18876405 chr7:65276391 NA -0.5 -6.65 -0.38 1.65e-10 Aortic root size; CESC cis rs4604732 0.642 rs4489599 chr1:247635213 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 -0.35 -5.28 -0.31 2.74e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg02269571 chr22:50332266 NA -0.54 -6.29 -0.36 1.33e-9 Schizophrenia; CESC cis rs7267979 0.844 rs6083824 chr20:25363057 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -14.75 -0.67 2.44e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs561341 1.000 rs8070262 chr17:30262467 A/G cg13647721 chr17:30228624 UTP6 0.52 5.32 0.31 2.17e-7 Hip circumference adjusted for BMI; CESC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg09323728 chr8:95962352 TP53INP1 -0.4 -9.06 -0.49 2.93e-17 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06057208 chr16:30535933 ZNF768 -0.53 -6.35 -0.36 9.51e-10 Gut microbiome composition (summer); CESC cis rs2645424 0.762 rs2294139 chr8:11705442 G/T cg21281001 chr8:11725306 CTSB 0.48 5.92 0.34 1e-8 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); CESC cis rs12477438 0.953 rs3851334 chr2:99794704 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -8.73 -0.47 3e-16 Chronic sinus infection; CESC cis rs12477438 0.520 rs6712704 chr2:99719687 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.61 0.69 2.15e-39 Chronic sinus infection; CESC cis rs1559088 0.847 rs10416218 chr19:33599127 T/C cg17764715 chr19:33622953 WDR88 0.48 6.33 0.36 1.04e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7072216 0.763 rs10883092 chr10:100167276 A/C cg26618903 chr10:100175079 PYROXD2 -0.35 -5.33 -0.31 2.1e-7 Metabolite levels; CESC cis rs35110281 0.782 rs6518309 chr21:45047992 C/A cg21573476 chr21:45109991 RRP1B -0.55 -7.21 -0.41 5.77e-12 Mean corpuscular volume; CESC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.9 10.02 0.52 3.04e-20 Platelet count; CESC cis rs11792861 0.816 rs744980 chr9:111690388 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 6.76 0.38 8.95e-11 Menarche (age at onset); CESC cis rs6496667 0.509 rs57962570 chr15:90985596 C/G cg22089800 chr15:90895588 ZNF774 0.42 5.42 0.32 1.37e-7 Rheumatoid arthritis; CESC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg19468946 chr17:37922297 IKZF3 0.39 5.03 0.3 8.9e-7 Glomerular filtration rate (creatinine); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11343870 chr11:67888858 CHKA -0.42 -6.37 -0.36 8.32e-10 Gambling; CESC cis rs1665050 0.534 rs56402153 chr15:59233312 A/G cg05156742 chr15:59063176 FAM63B 0.48 6.02 0.35 5.95e-9 Atopic dermatitis; CESC cis rs11229555 0.645 rs7116007 chr11:58218701 C/T cg15696309 chr11:58395628 NA -0.45 -5.19 -0.3 4.09e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs4604732 0.631 rs10925044 chr1:247627071 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.5 6.33 0.36 1.07e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9322193 0.923 rs9689084 chr6:149960784 G/A cg13206674 chr6:150067644 NUP43 0.42 5.99 0.35 6.91e-9 Lung cancer; CESC cis rs9916302 0.904 rs4794813 chr17:37670994 A/T cg15445000 chr17:37608096 MED1 0.41 6.5 0.37 4e-10 Glomerular filtration rate (creatinine); CESC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.75 0.55 1.32e-22 Height; CESC cis rs10791323 0.538 rs1105494 chr11:133698733 A/C cg06766960 chr11:133703094 NA 0.38 5.44 0.32 1.23e-7 Childhood ear infection; CESC cis rs6502050 0.697 rs8078634 chr17:80126208 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.42 -0.37 6.33e-10 Life satisfaction; CESC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg23803603 chr1:2058230 PRKCZ -0.34 -5.83 -0.34 1.63e-8 Height; CESC cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs11785400 0.793 rs1137521 chr8:143739162 C/T cg10596483 chr8:143751796 JRK 0.41 5.28 0.31 2.64e-7 Schizophrenia; CESC cis rs2180341 0.814 rs9321085 chr6:127735361 T/C cg24812749 chr6:127587940 RNF146 0.84 12.05 0.59 5.93e-27 Breast cancer; CESC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.46 5.55 0.32 6.76e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2531992 0.686 rs2041247 chr16:4032581 A/G cg05927578 chr16:4029543 ADCY9 0.52 7.0 0.39 2.16e-11 Waist circumference; CESC trans rs7246657 0.714 rs12972195 chr19:37752505 T/C cg24637308 chr11:6592297 DNHD1 0.52 6.0 0.35 6.36e-9 Coronary artery calcification; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15627031 chr1:45987517 PRDX1 0.47 6.05 0.35 4.92e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6546537 0.910 rs10779953 chr2:69886757 A/G cg10773587 chr2:69614142 GFPT1 -0.42 -5.16 -0.3 4.77e-7 Serum thyroid-stimulating hormone levels; CESC cis rs9914578 1.000 rs10459917 chr17:2009752 G/T cg16513277 chr17:2031491 SMG6 0.53 6.11 0.35 3.5e-9 Body mass index; CESC trans rs3942852 0.568 rs4412719 chr11:48101660 T/A cg03929089 chr4:120376271 NA -0.63 -7.78 -0.43 1.64e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs1008375 1.000 rs3846357 chr4:17635887 A/T cg15017067 chr4:17643749 FAM184B 0.36 5.19 0.3 4.25e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4722166 0.695 rs7808122 chr7:22798080 A/G cg05472934 chr7:22766657 IL6 0.62 8.27 0.45 6.75e-15 Lung cancer; CESC cis rs1983891 1.000 rs4714486 chr6:41542417 C/T cg20194872 chr6:41519635 FOXP4 0.55 7.76 0.43 1.88e-13 Prostate cancer; CESC cis rs4728302 0.869 rs7779370 chr7:133595702 T/C cg10665199 chr7:133106180 EXOC4 0.39 5.51 0.32 8.43e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs16867321 0.950 rs4667223 chr2:181498302 C/G cg23363182 chr2:181467187 NA -0.42 -5.49 -0.32 9.38e-8 Obesity; CESC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.56 -6.67 -0.38 1.45e-10 Prudent dietary pattern; CESC cis rs643506 0.874 rs680096 chr11:111708668 T/A cg17089665 chr11:111648010 NA -0.37 -5.37 -0.31 1.71e-7 Breast cancer; CESC cis rs6060717 0.528 rs73905955 chr20:34332938 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.25 0.31 3.15e-7 Hip circumference adjusted for BMI; CESC cis rs5417 0.636 rs222851 chr17:7139238 G/A cg13768953 chr17:7114967 DLG4 -0.37 -5.5 -0.32 9.01e-8 Diastolic blood pressure; CESC cis rs523522 0.926 rs10849766 chr12:121025894 G/A cg12219531 chr12:120966889 COQ5 0.77 10.04 0.53 2.56e-20 High light scatter reticulocyte count; CESC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg14829155 chr15:31115871 NA 0.74 10.63 0.55 3.3e-22 Huntington's disease progression; CESC cis rs12142240 0.698 rs1135459 chr1:46815930 C/T cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs796364 0.906 rs281784 chr2:200749749 T/A cg23649088 chr2:200775458 C2orf69 0.55 5.06 0.3 7.77e-7 Schizophrenia; CESC cis rs3733585 0.534 rs7375642 chr4:9955236 A/G cg00071950 chr4:10020882 SLC2A9 -0.69 -11.31 -0.57 1.83e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg11494091 chr17:61959527 GH2 0.73 12.49 0.61 1.88e-28 Prudent dietary pattern; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg27304813 chr3:120068385 LRRC58 0.49 6.5 0.37 3.99e-10 Weight; CESC cis rs933688 1.000 rs1895448 chr5:90743854 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.04 13.04 0.63 2.37e-30 Smoking behavior; CESC cis rs8067545 0.611 rs11653869 chr17:20197586 T/G cg13482628 chr17:19912719 NA -0.42 -5.61 -0.33 5.2e-8 Schizophrenia; CESC cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg02487422 chr3:49467188 NICN1 -0.39 -5.03 -0.3 9.15e-7 Menarche (age at onset); CESC cis rs854765 0.693 rs8079418 chr17:17924060 C/T cg04398451 chr17:18023971 MYO15A -0.61 -8.85 -0.48 1.32e-16 Total body bone mineral density; CESC cis rs10791323 0.517 rs1120245 chr11:133745290 A/G cg15485101 chr11:133734466 NA 0.3 5.13 0.3 5.52e-7 Childhood ear infection; CESC cis rs9905704 0.681 rs8081247 chr17:56557837 G/A cg12560992 chr17:57184187 TRIM37 -0.61 -5.57 -0.32 6.37e-8 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18014247 chr2:220083722 ABCB6 -0.56 -6.23 -0.36 1.83e-9 Gut microbiome composition (summer); CESC cis rs9303401 0.659 rs3809724 chr17:57061238 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.97 11.12 0.56 7.63e-24 Cognitive test performance; CESC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg27170947 chr2:26402098 FAM59B -0.84 -10.08 -0.53 1.98e-20 Gut microbiome composition (summer); CESC cis rs11997175 0.603 rs7008747 chr8:33834886 G/A ch.8.33884649F chr8:33765107 NA 0.44 5.17 0.3 4.73e-7 Body mass index; CESC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg26818010 chr10:134567672 INPP5A -0.94 -11.42 -0.57 7.62e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2243480 1.000 rs6958420 chr7:65751171 A/G cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs6893300 0.785 rs12522263 chr5:179176692 T/A cg14593053 chr5:179126677 CANX -0.45 -5.07 -0.3 7.62e-7 Resting heart rate; CESC cis rs16973500 0.808 rs61523290 chr16:71943556 A/G cg09427745 chr16:71932006 KIAA0174 -0.51 -5.26 -0.31 2.95e-7 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs80130819 0.748 rs7953726 chr12:48611757 A/G cg05342945 chr12:48394962 COL2A1 -0.48 -5.2 -0.3 4.07e-7 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26602477 chr1:1476845 C1orf70 0.48 6.67 0.38 1.52e-10 Fibrinogen levels; CESC cis rs28374715 0.532 rs316604 chr15:41775221 C/T cg02330683 chr15:41787940 ITPKA 0.42 5.16 0.3 4.77e-7 Ulcerative colitis; CESC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg23758822 chr17:41437982 NA 1.03 15.39 0.69 1.24e-38 Menopause (age at onset); CESC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg18099408 chr3:52552593 STAB1 -0.32 -5.32 -0.31 2.22e-7 Bipolar disorder; CESC cis rs80282103 0.618 rs74117831 chr10:1145707 A/C cg08668510 chr10:1095578 IDI1 0.77 6.34 0.36 1e-9 Glomerular filtration rate (creatinine); CESC cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7017914 0.967 rs7018381 chr8:71670117 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs854765 0.693 rs9907287 chr17:17774118 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.45 -5.84 -0.34 1.52e-8 Total body bone mineral density; CESC cis rs7429990 0.932 rs34025851 chr3:47953733 C/A cg11946769 chr3:48343235 NME6 0.46 5.62 0.33 4.91e-8 Educational attainment (years of education); CESC cis rs7648466 0.592 rs7616215 chr3:46205686 A/G cg08033130 chr3:45983597 CXCR6;FYCO1 -0.36 -5.05 -0.3 8.31e-7 Eotaxin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05694744 chr17:8191820 RANGRF;SLC25A35 -0.59 -6.45 -0.37 5.32e-10 Gut microbiome composition (summer); CESC cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg05234568 chr11:5960015 NA -0.63 -7.46 -0.42 1.2e-12 DNA methylation (variation); CESC cis rs11098499 0.710 rs6851130 chr4:120133712 G/A cg09307838 chr4:120376055 NA -0.67 -8.37 -0.46 3.41e-15 Corneal astigmatism; CESC cis rs4268898 0.552 rs7560342 chr2:24371691 T/C cg20701182 chr2:24300061 SF3B14 -0.39 -5.32 -0.31 2.23e-7 Asthma; CESC cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg16144293 chr14:75469539 EIF2B2 -0.4 -5.32 -0.31 2.22e-7 Height; CESC cis rs1348850 0.874 rs12996447 chr2:178283592 C/T cg23306229 chr2:178417860 TTC30B 0.61 7.82 0.43 1.25e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg06028605 chr16:24865363 SLC5A11 0.39 5.76 0.33 2.27e-8 Intelligence (multi-trait analysis); CESC cis rs911555 0.755 rs4906329 chr14:103942669 A/G cg24130564 chr14:104152367 KLC1 0.49 6.26 0.36 1.5e-9 Intelligence (multi-trait analysis); CESC cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg21918786 chr6:109611834 NA 0.4 6.01 0.35 6.01e-9 Reticulocyte fraction of red cells; CESC cis rs3916 0.794 rs10431384 chr12:121127347 C/T cg21892295 chr12:121157589 UNC119B 0.36 5.83 0.34 1.59e-8 Urinary metabolites (H-NMR features); CESC cis rs4699052 1.000 rs4699052 chr4:104137790 C/T cg16532752 chr4:104119610 CENPE -0.39 -5.41 -0.32 1.42e-7 Testicular germ cell tumor; CESC cis rs804280 0.564 rs4639 chr8:11644751 A/G cg12395012 chr8:11607386 GATA4 -0.49 -7.3 -0.41 3.33e-12 Myopia (pathological); CESC cis rs57506017 0.585 rs12669919 chr7:12271997 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.17 0.3 4.57e-7 Neuroticism; CESC cis rs11958404 1.000 rs9686690 chr5:157412103 C/T cg05962755 chr5:157440814 NA 0.52 5.95 0.34 8.38e-9 IgG glycosylation; CESC cis rs9811920 0.609 rs10936005 chr3:99674093 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 5.28 0.31 2.74e-7 Axial length; CESC cis rs11650494 0.908 rs77338752 chr17:47372328 A/C cg08112188 chr17:47440006 ZNF652 1.31 8.51 0.46 1.31e-15 Prostate cancer; CESC cis rs734999 0.545 rs10797441 chr1:2551660 T/G cg18854424 chr1:2615690 NA 0.3 5.88 0.34 1.2e-8 Ulcerative colitis; CESC cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9300255 0.602 rs1727294 chr12:123616514 A/G cg05973401 chr12:123451056 ABCB9 0.52 5.98 0.34 7.22e-9 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00144180 chr2:240294362 HDAC4 -0.64 -7.4 -0.41 1.78e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05139434 chr1:41328180 CITED4 0.58 6.74 0.38 1.01e-10 Gut microbiome composition (summer); CESC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg21963583 chr11:68658836 MRPL21 0.41 5.54 0.32 7.11e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs911555 0.511 rs2296483 chr14:104029792 G/A cg24130564 chr14:104152367 KLC1 -0.73 -11.9 -0.59 1.91e-26 Intelligence (multi-trait analysis); CESC cis rs6460942 1.000 rs75333414 chr7:12303829 T/A cg06484146 chr7:12443880 VWDE -0.68 -7.71 -0.43 2.55e-13 Coronary artery disease; CESC cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg00149659 chr3:10157352 C3orf10 0.99 12.05 0.59 6.02e-27 Alzheimer's disease; CESC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg25072359 chr17:41440525 NA 0.43 5.82 0.34 1.68e-8 Menopause (age at onset); CESC cis rs1062177 0.756 rs2915826 chr5:151119963 G/A cg00977110 chr5:151150581 G3BP1 -0.62 -6.36 -0.36 8.62e-10 Preschool internalizing problems; CESC cis rs7914558 1.000 rs4917996 chr10:104925829 A/C cg04362960 chr10:104952993 NT5C2 0.47 6.21 0.36 2e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6938 0.563 rs12917376 chr15:75116167 C/T cg14664628 chr15:75095509 CSK -0.69 -9.37 -0.5 3.3e-18 Breast cancer; CESC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg19622623 chr12:86230825 RASSF9 -0.47 -6.09 -0.35 4e-9 Major depressive disorder; CESC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg23034840 chr1:205782522 SLC41A1 0.64 7.41 0.41 1.74e-12 Menarche (age at onset); CESC cis rs7474896 0.559 rs1779075 chr10:38167530 C/G cg25427524 chr10:38739819 LOC399744 0.51 5.79 0.33 2.03e-8 Obesity (extreme); CESC cis rs672059 1.000 rs551569 chr1:183158293 G/C ch.1.3577855R chr1:183094577 LAMC1 0.54 6.97 0.39 2.51e-11 Hypertriglyceridemia; CESC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg12963246 chr6:28129442 ZNF389 0.55 7.21 0.4 5.85e-12 Depression; CESC cis rs864537 0.618 rs1214595 chr1:167427557 G/A cg09179987 chr1:167433047 CD247 0.53 7.83 0.43 1.17e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs611744 0.647 rs1379336 chr8:109276606 G/T cg21045802 chr8:109455806 TTC35 0.5 6.19 0.36 2.34e-9 Dupuytren's disease; CESC cis rs5769765 0.778 rs4574208 chr22:50256738 C/T cg02269571 chr22:50332266 NA 0.46 6.18 0.36 2.37e-9 Schizophrenia; CESC cis rs10129255 0.957 rs10140904 chr14:107184797 C/T cg07958169 chr14:107095056 NA -0.41 -5.67 -0.33 3.72e-8 Kawasaki disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24607948 chr9:100459097 XPA 0.48 6.07 0.35 4.37e-9 Gut microbiota (bacterial taxa); CESC cis rs11864453 0.826 rs2072142 chr16:72132713 C/T cg01557791 chr16:72042693 DHODH -0.51 -6.6 -0.38 2.17e-10 Fibrinogen levels; CESC cis rs4746818 1.000 rs10733850 chr10:70959617 C/T cg11621586 chr10:70884670 VPS26A 0.85 8.42 0.46 2.46e-15 Left atrial antero-posterior diameter; CESC cis rs916888 0.773 rs169201 chr17:44790203 A/G cg27589368 chr17:43923255 LOC100128977;IMP5 -0.39 -5.24 -0.31 3.28e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1355223 0.506 rs1828299 chr11:34870418 T/C cg11622362 chr11:34938112 PDHX;APIP 0.44 5.14 0.3 5.23e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9902453 0.765 rs2169810 chr17:28167941 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.01 0.52 3.14e-20 Coffee consumption (cups per day); CESC trans rs12479064 0.604 rs11893359 chr2:99954608 A/G cg20598333 chr11:3663511 ART5 0.5 6.05 0.35 4.82e-9 Chronic sinus infection; CESC cis rs7223966 0.921 rs2727300 chr17:61965398 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 6.89 0.39 3.95e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2204008 0.744 rs11182316 chr12:38499552 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.56 0.54 5.58e-22 Bladder cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15302530 chr7:108210038 THAP5;DNAJB9 0.43 6.16 0.35 2.76e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC trans rs7815720 0.866 rs17812918 chr8:118112784 G/A cg09024962 chr5:132707300 FSTL4 0.56 6.06 0.35 4.63e-9 Intraocular pressure; CESC cis rs8072100 0.713 rs2292346 chr17:45455473 G/A cg25173405 chr17:45401733 C17orf57 -0.43 -5.42 -0.32 1.36e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs9325144 0.555 rs7977200 chr12:38713745 C/T cg23762105 chr12:34175262 ALG10 -0.48 -6.42 -0.37 6.15e-10 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs4780401 0.609 rs35649585 chr16:11813899 G/A cg01061890 chr16:11836724 TXNDC11 -0.56 -7.58 -0.42 5.69e-13 Rheumatoid arthritis; CESC cis rs3733585 0.699 rs7676733 chr4:9966956 G/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.58 -0.32 5.96e-8 Cleft plate (environmental tobacco smoke interaction); CESC trans rs7618501 0.516 rs2856236 chr3:50161717 A/C cg21659725 chr3:3221576 CRBN -0.46 -6.31 -0.36 1.15e-9 Intelligence (multi-trait analysis); CESC cis rs11098499 0.820 rs12503082 chr4:120284317 A/G cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg07211511 chr3:129823064 LOC729375 -0.59 -7.42 -0.41 1.59e-12 Blood pressure (smoking interaction); CESC trans rs3780486 0.801 rs6476398 chr9:33119241 C/T cg20290983 chr6:43655470 MRPS18A 0.97 17.11 0.72 9.8e-45 IgG glycosylation; CESC cis rs1538970 0.924 rs1494812 chr1:45876999 C/T cg24296786 chr1:45957014 TESK2 -0.45 -5.22 -0.31 3.64e-7 Platelet count; CESC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg24549020 chr5:56110836 MAP3K1 0.41 5.08 0.3 7.24e-7 Coronary artery disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10620530 chr9:139922595 C9orf139;ABCA2 0.46 6.57 0.37 2.6e-10 Systemic lupus erythematosus; CESC cis rs2251381 0.808 rs7364112 chr21:30548968 C/A cg08807101 chr21:30365312 RNF160 0.65 8.07 0.44 2.42e-14 Selective IgA deficiency; CESC cis rs10751667 0.600 rs10751672 chr11:948712 T/C cg06064525 chr11:970664 AP2A2 -0.5 -9.88 -0.52 8.67e-20 Alzheimer's disease (late onset); CESC cis rs738322 1.000 rs133012 chr22:38570721 G/A cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC cis rs12474201 0.894 rs4952842 chr2:46925730 C/A cg06386533 chr2:46925753 SOCS5 0.91 12.72 0.62 3.09e-29 Height; CESC cis rs9457247 1.000 rs406095 chr6:167409087 C/T cg25258033 chr6:167368657 RNASET2 0.4 6.14 0.35 2.93e-9 Crohn's disease; CESC cis rs4242434 0.819 rs6558167 chr8:22473850 T/C cg03733263 chr8:22462867 KIAA1967 0.87 14.4 0.66 4.18e-35 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg10691866 chr7:65817282 TPST1 0.33 5.51 0.32 8.45e-8 Aortic root size; CESC cis rs9325144 0.555 rs7968322 chr12:38792348 T/C cg26384229 chr12:38710491 ALG10B -0.56 -7.87 -0.44 9.19e-14 Morning vs. evening chronotype; CESC cis rs11718455 0.960 rs35666538 chr3:44004826 A/G cg08738300 chr3:44038990 NA 0.46 6.12 0.35 3.34e-9 Coronary artery disease; CESC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg11965913 chr1:205819406 PM20D1 -0.44 -6.2 -0.36 2.19e-9 Menarche (age at onset); CESC cis rs763121 0.889 rs2267390 chr22:38889657 C/T cg06544989 chr22:39130855 UNC84B 0.47 7.88 0.44 8.68e-14 Menopause (age at onset); CESC cis rs3126085 0.560 rs11588022 chr1:152316952 A/T cg03465714 chr1:152285911 FLG 0.46 5.1 0.3 6.44e-7 Atopic dermatitis; CESC cis rs9287719 0.967 rs12692417 chr2:10745718 C/G cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03386556 chr1:113499109 SLC16A1 -0.43 -6.08 -0.35 4.12e-9 Asthma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05819912 chr4:170945459 MFAP3L -0.46 -6.49 -0.37 4.25e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs3942852 0.868 rs11039514 chr11:48109598 A/G cg15704280 chr7:45808275 SEPT13 -0.65 -7.64 -0.42 4.03e-13 Acute lymphoblastic leukemia (childhood); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19189965 chr12:123459820 ABCB9;OGFOD2 0.48 6.4 0.37 6.95e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1048238 0.506 rs6668183 chr1:16173814 G/C cg22431228 chr1:16359049 CLCNKA -0.38 -6.68 -0.38 1.43e-10 Systolic blood pressure; CESC cis rs2070488 0.775 rs4371464 chr3:38548021 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.75 -12.0 -0.59 8.82e-27 Electrocardiographic conduction measures; CESC cis rs2710642 0.721 rs1872790 chr2:62890222 T/C cg17519650 chr2:63277830 OTX1 0.56 6.7 0.38 1.28e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4664308 1.000 rs16844715 chr2:160915106 A/G cg03641300 chr2:160917029 PLA2R1 0.65 9.87 0.52 8.87e-20 Idiopathic membranous nephropathy; CESC cis rs11190604 1.000 rs2295773 chr10:102265815 A/G cg07080220 chr10:102295463 HIF1AN 0.64 5.88 0.34 1.23e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs10492096 1.000 rs10492096 chr12:6580582 A/G cg13857086 chr12:6580257 VAMP1 0.69 6.93 0.39 3.19e-11 Hip geometry; CESC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg22968622 chr17:43663579 NA -0.76 -9.99 -0.52 3.72e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11677370 0.603 rs1454242 chr2:3848532 G/A cg17052675 chr2:3827356 NA -0.44 -5.68 -0.33 3.56e-8 Type 2 diabetes; CESC cis rs17431357 1.000 rs73230328 chr12:121019639 G/A cg25045489 chr12:120971538 RNF10 -0.9 -5.23 -0.31 3.44e-7 Insulin resistance/response; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18382947 chr19:51308364 C19orf48 0.58 6.72 0.38 1.1e-10 Gut microbiome composition (summer); CESC cis rs2361718 0.527 rs11150847 chr17:78153130 G/A cg06718696 chr17:78121285 EIF4A3 0.5 6.78 0.38 7.99e-11 Yeast infection; CESC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg08027265 chr7:2291960 NA -0.44 -6.69 -0.38 1.29e-10 Bipolar disorder and schizophrenia; CESC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg02951883 chr7:2050386 MAD1L1 -0.45 -5.98 -0.34 7.06e-9 Bipolar disorder and schizophrenia; CESC cis rs6502050 0.835 rs8066284 chr17:80127825 C/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.97e-7 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00271154 chr2:113033418 ZC3H6 -0.69 -8.39 -0.46 3e-15 Gut microbiome composition (summer); CESC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg06634786 chr22:41940651 POLR3H 0.68 6.78 0.38 7.6e-11 Vitiligo; CESC cis rs9831754 1.000 rs9822043 chr3:78352113 T/C cg06138941 chr3:78371609 NA -0.77 -8.66 -0.47 4.76e-16 Calcium levels; CESC cis rs61931739 0.500 rs3934517 chr12:34451396 T/C cg23762105 chr12:34175262 ALG10 -0.4 -5.22 -0.31 3.7e-7 Morning vs. evening chronotype; CESC trans rs561341 0.714 rs473535 chr17:30312365 A/G cg27661571 chr11:113659931 NA -0.81 -7.55 -0.42 6.9e-13 Hip circumference adjusted for BMI; CESC cis rs8071789 1.000 rs8071789 chr17:38006333 C/T cg20243544 chr17:37824526 PNMT 0.53 7.14 0.4 8.83e-12 Selective IgA deficiency; CESC cis rs6502050 0.799 rs11491185 chr17:80151101 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.56e-7 Life satisfaction; CESC cis rs832540 0.931 rs1466008 chr5:56213406 G/C cg12311346 chr5:56204834 C5orf35 -0.43 -5.43 -0.32 1.25e-7 Coronary artery disease; CESC cis rs4148883 0.615 rs2187483 chr4:100134103 G/T cg13256891 chr4:100009986 ADH5 -0.44 -5.72 -0.33 2.94e-8 Alcohol dependence; CESC cis rs1707322 0.686 rs1547924 chr1:46085112 C/T cg03146154 chr1:46216737 IPP 0.79 10.88 0.56 4.78e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7872515 0.775 rs7024583 chr9:94824750 C/T cg01248375 chr9:94877805 SPTLC1 0.49 5.25 0.31 3.08e-7 Bipolar disorder and schizophrenia; CESC cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg05535760 chr7:792225 HEATR2 -0.8 -8.26 -0.45 6.78e-15 Cerebrospinal P-tau181p levels; CESC cis rs8072100 0.817 rs9892497 chr17:45545919 G/A cg08085267 chr17:45401833 C17orf57 -0.58 -7.68 -0.43 3.15e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs3747547 0.818 rs67198935 chr9:37932797 T/G cg13774184 chr9:37916125 SHB -0.5 -5.24 -0.31 3.26e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs365132 1.000 rs601923 chr5:176417386 C/G cg16309518 chr5:176445507 NA -0.39 -5.73 -0.33 2.68e-8 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs2404618 0.593 rs7829532 chr8:1485190 C/A cg13402656 chr8:1511478 DLGAP2 -0.53 -7.45 -0.42 1.34e-12 Lung cancer; CESC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.42 -0.32 1.31e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.25e-30 Prudent dietary pattern; CESC cis rs35146811 0.586 rs10267231 chr7:99595480 T/C cg22531904 chr7:99595276 NA -0.38 -5.04 -0.3 8.84e-7 Coronary artery disease; CESC cis rs55728055 0.661 rs62237845 chr22:32027892 G/A cg01338084 chr22:32026380 PISD 1.26 8.23 0.45 8.62e-15 Age-related hearing impairment; CESC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.49 0.32 9.47e-8 Bipolar disorder; CESC cis rs6121246 0.529 rs6060134 chr20:30176794 A/G cg13852791 chr20:30311386 BCL2L1 0.57 5.5 0.32 9.14e-8 Mean corpuscular hemoglobin; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13243329 chr1:212782207 ATF3 -0.48 -6.11 -0.35 3.55e-9 Ulcerative colitis; CESC cis rs17376456 0.825 rs34592268 chr5:93232751 G/C cg25358565 chr5:93447407 FAM172A 1.1 10.79 0.55 9.8e-23 Diabetic retinopathy; CESC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg20151795 chr6:28129481 ZNF389 0.45 5.92 0.34 9.77e-9 Parkinson's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27337021 chr5:139947627 SLC35A4 0.43 6.14 0.35 3.07e-9 Fibrinogen levels; CESC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg22920501 chr2:26401640 FAM59B -0.85 -9.95 -0.52 5.11e-20 Gut microbiome composition (summer); CESC cis rs11696501 0.688 rs4812955 chr20:44324638 G/C cg11783356 chr20:44313418 WFDC10B -0.34 -5.28 -0.31 2.76e-7 Brain structure; CESC cis rs1538970 1.000 rs17395553 chr1:45864761 C/T cg06784218 chr1:46089804 CCDC17 0.34 5.67 0.33 3.68e-8 Platelet count; CESC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.36 6.63 0.38 1.85e-10 Electroencephalogram traits; CESC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg11644478 chr21:40555479 PSMG1 -0.8 -11.95 -0.59 1.27e-26 Cognitive function; CESC cis rs3733585 0.638 rs7377625 chr4:9953099 T/C cg11266682 chr4:10021025 SLC2A9 -0.58 -11.05 -0.56 1.39e-23 Cleft plate (environmental tobacco smoke interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05875433 chr3:130465895 PIK3R4 -0.49 -6.84 -0.39 5.4e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg18446336 chr7:2847575 GNA12 -0.37 -5.59 -0.32 5.76e-8 Height; CESC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg08736216 chr1:53307985 ZYG11A -0.4 -7.04 -0.4 1.6e-11 Monocyte count; CESC cis rs2637266 0.967 rs7900230 chr10:78366879 A/G cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs9549260 0.816 rs7337995 chr13:41249040 A/G cg21288729 chr13:41239152 FOXO1 0.63 7.77 0.43 1.75e-13 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23057831 chr8:82633454 ZFAND1 0.55 6.06 0.35 4.58e-9 Gut microbiome composition (summer); CESC cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg27398817 chr8:82754497 SNX16 -0.53 -6.25 -0.36 1.63e-9 Diastolic blood pressure; CESC cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg18180107 chr4:99064573 C4orf37 0.4 5.18 0.3 4.42e-7 Colonoscopy-negative controls vs population controls; CESC trans rs4906172 0.716 rs8013679 chr14:102506308 A/G cg17920195 chr4:129149383 NA 0.31 6.17 0.35 2.57e-9 Menopause (age at onset); CESC trans rs11722228 0.522 rs881641 chr4:10133747 G/A cg26043149 chr18:55253948 FECH 1.01 12.98 0.62 3.9e-30 Gout;Urate levels;Serum uric acid levels; CESC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg02725872 chr8:58115012 NA -0.44 -5.98 -0.34 7.21e-9 Developmental language disorder (linguistic errors); CESC cis rs2235544 0.513 rs10158824 chr1:54480398 C/G cg25741118 chr1:54482237 LDLRAD1 0.23 5.87 0.34 1.31e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg06022373 chr22:39101656 GTPBP1 -0.89 -13.81 -0.65 4.77e-33 Menopause (age at onset); CESC cis rs2952156 1.000 rs2934971 chr17:37854507 G/T cg20243544 chr17:37824526 PNMT 0.61 7.42 0.41 1.61e-12 Asthma; CESC cis rs763121 0.853 rs4821808 chr22:39065739 A/G cg21395723 chr22:39101663 GTPBP1 0.42 5.27 0.31 2.86e-7 Menopause (age at onset); CESC cis rs644799 1.000 rs566204 chr11:95580926 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.57 6.74 0.38 9.95e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2404602 0.692 rs67010831 chr15:76965308 T/G cg26408565 chr15:76604113 ETFA -0.39 -5.71 -0.33 2.98e-8 Blood metabolite levels; CESC cis rs9815354 0.638 rs73071259 chr3:42001847 G/A cg03022575 chr3:42003672 ULK4 0.66 5.77 0.33 2.17e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg27170947 chr2:26402098 FAM59B 0.69 8.1 0.45 2.07e-14 Gut microbiome composition (summer); CESC cis rs7336332 0.598 rs76790205 chr13:28002885 C/T cg22138327 chr13:27999177 GTF3A 0.64 5.96 0.34 8.09e-9 Weight; CESC cis rs2985684 1.000 rs2985684 chr14:50101682 C/G cg02151108 chr14:50098012 C14orf104 -0.42 -5.48 -0.32 9.97e-8 Carotid intima media thickness; CESC cis rs4835473 0.900 rs5015759 chr4:144659203 C/G cg25736465 chr4:144833511 NA -0.33 -5.2 -0.3 4.04e-7 Immature fraction of reticulocytes; CESC cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg04455712 chr21:45112962 RRP1B 0.38 5.6 0.33 5.4e-8 Mean corpuscular volume; CESC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg24829409 chr8:58192753 C8orf71 -0.67 -7.37 -0.41 2.23e-12 Developmental language disorder (linguistic errors); CESC cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg24308560 chr3:49941425 MST1R -0.63 -9.23 -0.49 8.99e-18 Intelligence (multi-trait analysis); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg05485520 chr3:45883628 LZTFL1 0.49 6.69 0.38 1.29e-10 Systemic lupus erythematosus; CESC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg00121533 chr1:75199117 CRYZ;TYW3 0.54 7.47 0.42 1.2e-12 Resistin levels; CESC trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21659725 chr3:3221576 CRBN 0.83 13.44 0.64 9.18e-32 Intelligence (multi-trait analysis); CESC cis rs12477438 0.765 rs28648058 chr2:99696417 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.58 -0.47 7.87e-16 Chronic sinus infection; CESC cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg02079420 chr8:82753780 SNX16 -0.53 -8.1 -0.45 2.07e-14 Diastolic blood pressure; CESC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.56 0.47 9.4e-16 Bipolar disorder; CESC cis rs10791323 0.569 rs5019134 chr11:133713082 G/C cg14349672 chr11:133703707 NA -0.36 -5.06 -0.3 7.92e-7 Childhood ear infection; CESC trans rs4332037 0.851 rs73050128 chr7:1961882 C/A cg11693508 chr17:37793320 STARD3 0.7 6.8 0.39 7e-11 Bipolar disorder; CESC cis rs7617773 0.817 rs11710861 chr3:48297560 C/T cg11946769 chr3:48343235 NME6 0.79 10.54 0.54 6.33e-22 Coronary artery disease; CESC cis rs9788682 1.000 rs34138960 chr15:78831668 A/G cg06917634 chr15:78832804 PSMA4 -0.55 -6.49 -0.37 4.15e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs57083693 0.500 rs11110751 chr12:101718142 T/C cg22051763 chr12:101673672 UTP20 -0.44 -5.5 -0.32 8.91e-8 Alcohol dependence (age at onset); CESC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg23281280 chr6:28129359 ZNF389 0.56 7.62 0.42 4.55e-13 Depression; CESC cis rs59918340 0.764 rs4961258 chr8:142232878 A/G cg23750338 chr8:142222470 SLC45A4 -0.6 -9.09 -0.49 2.31e-17 Immature fraction of reticulocytes; CESC cis rs3892630 0.817 rs12609866 chr19:33184412 C/T cg13157960 chr19:33183277 NUDT19 0.53 5.2 0.3 4.04e-7 Red blood cell traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25433855 chr4:102268622 PPP3CA -0.61 -7.26 -0.41 4.26e-12 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs56378576 chr17:29010120 C/T cg19761014 chr17:28927070 LRRC37B2 0.81 6.67 0.38 1.49e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10870270 1.000 rs72636963 chr10:133771271 C/T cg17892150 chr10:133769511 PPP2R2D -0.87 -12.77 -0.62 2.05e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs6032067 0.850 rs4566421 chr20:43783761 G/T cg10761708 chr20:43804764 PI3 0.55 5.96 0.34 7.91e-9 Blood protein levels; CESC trans rs9858542 0.953 rs11719996 chr3:49525958 T/C cg21659725 chr3:3221576 CRBN -0.55 -6.49 -0.37 4.22e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs34779708 0.931 rs35388511 chr10:35296616 A/G cg03585969 chr10:35415529 CREM 0.75 9.74 0.51 2.26e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs67311347 0.577 rs11712626 chr3:40259927 G/A cg09455208 chr3:40491958 NA 0.35 5.5 0.32 8.99e-8 Renal cell carcinoma; CESC cis rs1538970 0.924 rs11211108 chr1:45891152 C/T cg24296786 chr1:45957014 TESK2 -0.46 -5.3 -0.31 2.41e-7 Platelet count; CESC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg06505273 chr16:24850292 NA 0.5 5.38 0.31 1.66e-7 Intelligence (multi-trait analysis); CESC cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg26850624 chr5:429559 AHRR -0.41 -5.97 -0.34 7.41e-9 Cystic fibrosis severity; CESC trans rs11098499 0.954 rs3733520 chr4:120423480 C/G cg25214090 chr10:38739885 LOC399744 0.71 10.03 0.52 2.81e-20 Corneal astigmatism; CESC cis rs9733 0.744 rs11204737 chr1:150847647 C/T cg13175981 chr1:150552382 MCL1 0.5 6.82 0.39 5.97e-11 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09348431 chr8:144898112 SCRIB 0.6 6.96 0.39 2.69e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02909592 chr3:149181944 NA -0.62 -7.54 -0.42 7.42e-13 Gut microbiome composition (summer); CESC cis rs8017423 1.000 rs2184281 chr14:90685923 A/G cg14092571 chr14:90743983 NA 0.53 7.78 0.43 1.63e-13 Mortality in heart failure; CESC cis rs300703 0.655 rs300798 chr2:105917 A/G cg21211680 chr2:198530 NA -1.0 -9.26 -0.49 7.45e-18 Blood protein levels; CESC cis rs4144743 0.641 rs67696888 chr17:45355116 A/G cg18085866 chr17:45331354 ITGB3 -0.58 -5.59 -0.32 5.61e-8 Body mass index; CESC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg00684032 chr4:1343700 KIAA1530 -0.37 -5.13 -0.3 5.61e-7 Obesity-related traits; CESC cis rs3796352 0.892 rs2581807 chr3:53088844 G/A cg12962167 chr3:53033115 SFMBT1 -0.59 -5.7 -0.33 3.22e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs17125944 0.505 rs2295826 chr14:53174923 C/T cg13660082 chr14:53194042 PSMC6 0.62 5.84 0.34 1.54e-8 Alzheimer's disease (late onset); CESC cis rs1538970 0.924 rs11211117 chr1:45930246 C/T cg05343316 chr1:45956843 TESK2 0.89 12.12 0.6 3.27e-27 Platelet count; CESC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg24154853 chr7:158122151 PTPRN2 0.44 6.97 0.39 2.53e-11 Calcium levels; CESC cis rs1003719 0.788 rs11911508 chr21:38470504 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00720027 chr8:42249732 VDAC3 0.64 6.99 0.39 2.28e-11 Gut microbiome composition (summer); CESC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg03526776 chr6:41159608 TREML2 -0.32 -6.0 -0.35 6.56e-9 Alzheimer's disease (late onset); CESC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg25405998 chr7:65216604 CCT6P1 0.45 5.17 0.3 4.6e-7 Aortic root size; CESC cis rs4727027 0.899 rs7791496 chr7:148863674 C/G cg23583168 chr7:148888333 NA -0.81 -12.7 -0.62 3.49e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7927592 0.956 rs60212556 chr11:68305494 C/T cg16797656 chr11:68205561 LRP5 0.4 5.51 0.32 8.36e-8 Total body bone mineral density; CESC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg11663144 chr21:46675770 NA -0.63 -9.75 -0.51 2.19e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs796364 0.806 rs203766 chr2:200902672 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.83 -7.71 -0.43 2.49e-13 Schizophrenia; CESC cis rs5758659 0.904 rs134877 chr22:42662371 C/T cg15557168 chr22:42548783 NA -0.51 -8.27 -0.45 6.58e-15 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20159777 chr1:203296550 NA 0.66 7.22 0.41 5.41e-12 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg07701084 chr6:150067640 NUP43 0.49 6.91 0.39 3.56e-11 Lung cancer; CESC cis rs7236492 0.627 rs76032846 chr18:77198322 G/A cg15644404 chr18:77186268 NFATC1 -0.67 -5.06 -0.3 7.67e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs4319547 1.000 rs7309390 chr12:123110422 A/G cg23029597 chr12:123009494 RSRC2 -0.46 -5.14 -0.3 5.3e-7 Body mass index; CESC cis rs3857067 0.806 rs4693375 chr4:95133241 C/A cg11021082 chr4:95130006 SMARCAD1 -0.66 -10.02 -0.52 2.93e-20 QT interval; CESC trans rs11992162 0.636 rs4841646 chr8:11798707 C/G cg15556689 chr8:8085844 FLJ10661 0.52 6.46 0.37 4.98e-10 Monocyte count; CESC trans rs2727020 0.576 rs61885308 chr11:49343363 G/A cg03929089 chr4:120376271 NA -0.6 -7.51 -0.42 8.87e-13 Coronary artery disease; CESC cis rs1707322 0.686 rs2991979 chr1:46055858 A/G cg06784218 chr1:46089804 CCDC17 -0.41 -7.11 -0.4 1.07e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01002995 chr12:8185077 FOXJ2 0.55 6.09 0.35 3.94e-9 Gut microbiome composition (summer); CESC cis rs2404602 0.647 rs12439141 chr15:77095423 T/C cg23625390 chr15:77176239 SCAPER -0.4 -5.24 -0.31 3.32e-7 Blood metabolite levels; CESC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg11301795 chr4:187892539 NA -0.77 -12.15 -0.6 2.73e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs643506 0.874 rs582465 chr11:111668585 C/T cg17089665 chr11:111648010 NA -0.38 -5.55 -0.32 7.03e-8 Breast cancer; CESC cis rs6964587 1.000 rs7811873 chr7:91751120 G/A cg17063962 chr7:91808500 NA 0.58 8.06 0.44 2.57e-14 Breast cancer; CESC cis rs3749237 1.000 rs3749237 chr3:49770032 C/T cg03060546 chr3:49711283 APEH 0.6 7.29 0.41 3.65e-12 Resting heart rate; CESC cis rs7089973 0.872 rs34683721 chr10:116619849 G/A cg23260525 chr10:116636907 FAM160B1 0.38 6.42 0.37 6.35e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs8027181 0.682 rs4777546 chr15:73104435 C/T cg25632853 chr15:73088954 NA -0.31 -5.41 -0.32 1.43e-7 Triglyceride levels; CESC cis rs8070740 0.592 rs2189338 chr17:5326341 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.58 7.55 0.42 7e-13 Menopause (age at onset); CESC cis rs76419734 0.510 rs3943980 chr4:106676766 G/A cg24545054 chr4:106630052 GSTCD;INTS12 -0.62 -6.47 -0.37 4.62e-10 Post bronchodilator FEV1; CESC cis rs6974235 0.806 rs42068 chr7:95716570 A/G cg21022364 chr7:95948586 SLC25A13 0.39 5.56 0.32 6.61e-8 Total body bone mineral density; CESC cis rs11168351 0.927 rs10875716 chr12:48389023 C/T cg24011408 chr12:48396354 COL2A1 0.54 8.13 0.45 1.69e-14 Bipolar disorder and schizophrenia; CESC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg08888203 chr3:10149979 C3orf24 0.46 6.03 0.35 5.45e-9 Alzheimer's disease; CESC cis rs2228479 0.850 rs62052714 chr16:89857180 T/C cg06558623 chr16:89946397 TCF25 1.18 9.44 0.5 1.97e-18 Skin colour saturation; CESC cis rs1568889 1.000 rs35343234 chr11:28034379 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 9.0 0.48 4.61e-17 Bipolar disorder; CESC cis rs67478160 0.643 rs4900600 chr14:104291839 A/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.66 0.55 2.59e-22 Schizophrenia; CESC cis rs116095464 0.558 rs9688045 chr5:254035 T/C cg10591111 chr5:226296 SDHA -0.51 -6.15 -0.35 2.84e-9 Breast cancer; CESC cis rs919433 0.963 rs13033821 chr2:198173536 T/G cg03934865 chr2:198174659 NA -0.42 -5.55 -0.32 6.94e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs41357746 0.525 rs57030473 chr15:67776678 A/G cg05081167 chr6:156967138 NA 0.3 6.18 0.35 2.43e-9 Total body bone mineral density; CESC cis rs694739 0.628 rs11606081 chr11:64137875 T/C cg23796481 chr11:64053134 BAD;GPR137 0.58 7.09 0.4 1.23e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg01341218 chr17:43662625 NA 0.52 6.98 0.39 2.34e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg18252515 chr7:66147081 NA -0.44 -5.74 -0.33 2.52e-8 Aortic root size; CESC cis rs59918340 0.764 rs3824234 chr8:142229370 T/C cg23750338 chr8:142222470 SLC45A4 0.62 9.26 0.49 7.03e-18 Immature fraction of reticulocytes; CESC cis rs9308731 0.569 rs7585054 chr2:111944927 A/G cg04202892 chr2:111875749 ACOXL 0.37 5.17 0.3 4.61e-7 Chronic lymphocytic leukemia; CESC cis rs72781680 0.611 rs6720131 chr2:24364736 C/T cg20701182 chr2:24300061 SF3B14 0.95 10.52 0.54 7.35e-22 Lymphocyte counts; CESC cis rs2017305 0.834 rs12253140 chr10:70780708 G/T cg01024728 chr10:70782572 NA 0.57 5.41 0.32 1.4e-7 Depression (quantitative trait); CESC cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg21918786 chr6:109611834 NA -0.36 -5.22 -0.31 3.63e-7 Reticulocyte fraction of red cells; CESC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg07936489 chr17:37558343 FBXL20 -0.79 -11.38 -0.57 1.07e-24 Glomerular filtration rate (creatinine); CESC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg11890956 chr21:40555474 PSMG1 1.04 16.54 0.71 1.1e-42 Cognitive function; CESC cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.5 0.61 1.73e-28 Colonoscopy-negative controls vs population controls; CESC trans rs7839040 0.698 rs7841608 chr8:82929786 C/G cg14472086 chr9:107730925 NA -0.47 -6.28 -0.36 1.38e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs4566357 0.615 rs2894626 chr2:227916039 T/C cg11843606 chr2:227700838 RHBDD1 -0.52 -7.01 -0.4 1.92e-11 Coronary artery disease; CESC cis rs1008375 0.932 rs12500947 chr4:17603424 C/T cg02297831 chr4:17616191 MED28 0.54 6.73 0.38 1.06e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2439831 0.681 rs540031 chr15:43608855 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.82 12.43 0.61 3.03e-28 Lung cancer in ever smokers; CESC cis rs2228479 0.717 rs2286392 chr16:89809549 A/G cg00800038 chr16:89945340 TCF25 -0.71 -7.24 -0.41 4.76e-12 Skin colour saturation; CESC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg23281280 chr6:28129359 ZNF389 0.59 8.16 0.45 1.34e-14 Depression; CESC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.21e-13 Prudent dietary pattern; CESC cis rs1832871 0.672 rs9456286 chr6:158734315 A/G cg07165851 chr6:158734300 TULP4 0.6 6.57 0.37 2.63e-10 Height; CESC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg06505273 chr16:24850292 NA -0.53 -6.49 -0.37 4.27e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs3733585 0.699 rs6449158 chr4:9960459 T/C cg11266682 chr4:10021025 SLC2A9 -0.6 -11.15 -0.57 6.33e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs8073060 0.586 rs72828038 chr17:33893908 C/A cg19694781 chr19:47549865 TMEM160 0.69 6.72 0.38 1.11e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs400736 0.740 rs9434981 chr1:8111314 G/C cg25007680 chr1:8021821 PARK7 0.71 9.97 0.52 4.51e-20 Response to antidepressants and depression; CESC cis rs8078723 0.677 rs8073254 chr17:38149350 C/G cg17467752 chr17:38218738 THRA -0.57 -8.58 -0.47 8.38e-16 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs1707322 1.000 rs6661500 chr1:46465662 T/C cg05343316 chr1:45956843 TESK2 0.44 5.29 0.31 2.62e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35955747 0.934 rs13053245 chr22:31816742 G/C cg25791279 chr22:32026902 PISD -0.44 -5.31 -0.31 2.28e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg21226059 chr5:178986404 RUFY1 0.42 6.12 0.35 3.38e-9 Lung cancer; CESC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg24846343 chr22:24311635 DDTL 0.66 11.37 0.57 1.2e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs778371 0.723 rs12105766 chr2:233617647 A/G cg08000102 chr2:233561755 GIGYF2 0.83 13.68 0.64 1.35e-32 Schizophrenia; CESC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.12 0.53 1.44e-20 Prudent dietary pattern; CESC cis rs11077998 0.967 rs4789782 chr17:80489323 G/T cg10255544 chr17:80519551 FOXK2 -0.54 -8.81 -0.48 1.73e-16 Reticulocyte fraction of red cells; CESC cis rs4319547 0.915 rs1473553 chr12:122985057 G/T cg23029597 chr12:123009494 RSRC2 -0.5 -5.43 -0.32 1.26e-7 Body mass index; CESC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg21782813 chr7:2030301 MAD1L1 0.49 6.84 0.39 5.53e-11 Bipolar disorder and schizophrenia; CESC cis rs933688 0.532 rs973332 chr5:90555129 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.44 -5.11 -0.3 6.1e-7 Smoking behavior; CESC cis rs933688 1.000 rs12654787 chr5:90713259 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 12.45 0.61 2.47e-28 Smoking behavior; CESC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs2635047 0.615 rs9304343 chr18:44720664 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.13 0.3 5.49e-7 Educational attainment; CESC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg18252515 chr7:66147081 NA 0.4 5.13 0.3 5.59e-7 Aortic root size; CESC cis rs10504229 0.679 rs12375445 chr8:58040082 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -6.85 -0.39 5e-11 Developmental language disorder (linguistic errors); CESC cis rs6942756 0.747 rs691435 chr7:129097352 C/T cg02491457 chr7:128862824 NA 0.57 7.99 0.44 4.06e-14 White matter hyperintensity burden; CESC trans rs877282 0.629 rs78997110 chr10:764388 A/G cg22713356 chr15:30763199 NA 1.16 10.88 0.56 5.1e-23 Uric acid levels; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg10163580 chr2:191742848 NA 0.4 6.01 0.35 6.27e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs56235845 0.694 rs9313758 chr5:176773091 T/G cg17509989 chr5:176798049 RGS14 0.5 6.3 0.36 1.24e-9 Hemoglobin concentration;Hematocrit; CESC cis rs6460942 0.524 rs6948366 chr7:12369905 A/G cg20607287 chr7:12443886 VWDE -0.57 -8.19 -0.45 1.1e-14 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23487303 chr19:59086729 MGC2752 0.56 6.02 0.35 5.79e-9 Gut microbiome composition (summer); CESC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg22903471 chr2:27725779 GCKR -0.59 -8.52 -0.46 1.23e-15 Total body bone mineral density; CESC cis rs10129255 0.500 rs6576226 chr14:107186374 G/A cg23076370 chr14:107095027 NA -0.65 -9.67 -0.51 3.98e-19 Kawasaki disease; CESC cis rs2072499 0.966 rs1060604 chr1:156184268 T/C cg06970220 chr1:156163860 SLC25A44 0.39 5.05 0.3 8.14e-7 Testicular germ cell tumor; CESC cis rs9300255 0.596 rs1568427 chr12:123738678 A/G cg00376283 chr12:123451042 ABCB9 0.66 8.88 0.48 1.02e-16 Neutrophil percentage of white cells; CESC cis rs2290159 0.800 rs2290162 chr3:12647457 A/G cg23032965 chr3:12705835 RAF1 0.51 5.63 0.33 4.48e-8 Cholesterol, total; CESC cis rs559928 0.606 rs12417635 chr11:63912728 C/T cg18225595 chr11:63971243 STIP1 0.64 5.82 0.34 1.73e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg05564831 chr3:52568323 NT5DC2 -0.46 -6.64 -0.38 1.79e-10 Bipolar disorder; CESC cis rs7107174 1.000 rs2511177 chr11:77922960 C/T cg02023728 chr11:77925099 USP35 0.39 5.59 0.32 5.76e-8 Testicular germ cell tumor; CESC cis rs8077889 0.869 rs11713 chr17:41845824 A/G cg26893861 chr17:41843967 DUSP3 -0.66 -7.77 -0.43 1.71e-13 Triglycerides; CESC cis rs79349575 0.749 rs8182364 chr17:47018025 A/G cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21416968 chr1:44441199 ATP6V0B 0.61 7.33 0.41 2.79e-12 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03900353 chr1:212732456 NA 0.46 6.0 0.35 6.41e-9 Gut microbiota (bacterial taxa); CESC cis rs9902453 0.868 rs9896012 chr17:28470091 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.29 0.45 5.59e-15 Coffee consumption (cups per day); CESC cis rs7638995 0.878 rs1995665 chr3:69183140 A/C cg26574240 chr3:69171822 LMOD3 -0.47 -5.11 -0.3 6.04e-7 Alzheimer's disease (late onset); CESC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.81 0.39 6.56e-11 Platelet count; CESC cis rs7937682 0.924 rs875257 chr11:111530453 A/G cg09085632 chr11:111637200 PPP2R1B -1.0 -16.56 -0.71 9.02e-43 Primary sclerosing cholangitis; CESC cis rs9549367 0.713 rs3024769 chr13:113825601 A/C cg18105134 chr13:113819100 PROZ 0.64 8.3 0.45 5.53e-15 Platelet distribution width; CESC trans rs10776614 0.799 rs12358311 chr10:49765337 A/G cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC trans rs11989744 1.000 rs11989744 chr8:23567463 A/G cg03492747 chr16:86543808 FOXF1 -0.63 -7.33 -0.41 2.84e-12 Waist-hip ratio; CESC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg03060546 chr3:49711283 APEH 0.59 8.38 0.46 3.15e-15 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs1712517 0.566 rs1163073 chr10:105022934 C/T cg04362960 chr10:104952993 NT5C2 0.45 5.34 0.31 2.01e-7 Migraine; CESC cis rs6733011 0.542 rs6542860 chr2:99679376 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.41 -5.34 -0.31 1.96e-7 Bipolar disorder; CESC cis rs863345 0.808 rs7517316 chr1:158469914 A/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.56 -0.32 6.42e-8 Pneumococcal bacteremia; CESC cis rs12681288 0.676 rs935820 chr8:1022168 A/G cg04851639 chr8:1020857 NA -0.36 -8.01 -0.44 3.65e-14 Schizophrenia; CESC cis rs1062177 0.855 rs6892117 chr5:151264985 C/T cg12924095 chr5:151150029 G3BP1 -0.39 -5.46 -0.32 1.09e-7 Preschool internalizing problems; CESC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg11644478 chr21:40555479 PSMG1 -0.79 -11.72 -0.58 7.8e-26 Cognitive function; CESC cis rs12142240 0.698 rs6690075 chr1:46819848 G/A cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs147766666 1 rs147766666 chr16:67829763 TAAAC/T cg26727032 chr16:67993705 SLC12A4 -0.59 -5.63 -0.33 4.48e-8 Hematocrit;Hemoglobin concentration; CESC cis rs9902453 0.845 rs2321493 chr17:28230359 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.2 0.45 1.05e-14 Coffee consumption (cups per day); CESC cis rs7927771 1.000 rs10838738 chr11:47663049 A/G cg05585544 chr11:47624801 NA -0.53 -8.36 -0.46 3.55e-15 Subjective well-being; CESC cis rs2637266 0.967 rs2395407 chr10:78380573 T/A cg18941641 chr10:78392320 NA 0.43 8.17 0.45 1.28e-14 Pulmonary function; CESC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.64 6.68 0.38 1.44e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2228479 0.717 rs1800358 chr16:89809319 T/C cg00800038 chr16:89945340 TCF25 -0.71 -7.24 -0.41 4.76e-12 Skin colour saturation; CESC cis rs4835473 0.932 rs1450235 chr4:144704080 A/G cg25736465 chr4:144833511 NA 0.43 6.39 0.37 7.62e-10 Immature fraction of reticulocytes; CESC cis rs2154427 0.752 rs79114597 chr21:34200730 C/A cg21871883 chr21:34145043 C21orf49;C21orf66 0.62 5.15 0.3 5.15e-7 Bilirubin levels; CESC cis rs796364 0.901 rs35572201 chr2:201035093 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.62 -5.95 -0.34 8.43e-9 Schizophrenia; CESC cis rs1348850 0.526 rs9288003 chr2:178446572 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 5.13 0.3 5.69e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3784262 0.967 rs4646612 chr15:58265077 C/T cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.08 -0.3 7.03e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs7191439 0.858 rs7205626 chr16:88780472 T/C cg27087555 chr16:88793112 FAM38A -1.15 -9.92 -0.52 6.06e-20 Plateletcrit; CESC trans rs561341 0.941 rs501773 chr17:30314435 T/G cg27661571 chr11:113659931 NA -0.72 -7.45 -0.42 1.31e-12 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24875440 chr1:27986375 NA 0.57 6.81 0.39 6.54e-11 Gut microbiome composition (summer); CESC cis rs722599 0.683 rs7160852 chr14:75239424 T/C cg08847533 chr14:75593920 NEK9 0.5 6.1 0.35 3.79e-9 IgG glycosylation; CESC cis rs6901004 0.688 rs34151782 chr6:111574537 T/A cg15721981 chr6:111408429 SLC16A10 0.38 5.43 0.32 1.26e-7 Blood metabolite levels; CESC cis rs72627123 0.656 rs117145347 chr14:74564164 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.74 5.12 0.3 5.89e-7 Morning vs. evening chronotype; CESC cis rs16866061 0.962 rs72972361 chr2:225341550 G/A cg12698349 chr2:225449008 CUL3 0.72 10.98 0.56 2.37e-23 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs9815354 0.597 rs60690674 chr3:41997811 G/C cg03022575 chr3:42003672 ULK4 0.64 5.69 0.33 3.42e-8 Pulse pressure;Diastolic blood pressure; CESC trans rs9325144 0.560 rs11182979 chr12:38642562 C/A cg23762105 chr12:34175262 ALG10 0.48 6.31 0.36 1.16e-9 Morning vs. evening chronotype; CESC cis rs57994353 0.598 rs72775768 chr9:139324574 C/T cg14019695 chr9:139328340 INPP5E 0.4 5.1 0.3 6.55e-7 Eosinophil counts;Cutaneous squamous cell carcinoma; CESC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg16145915 chr7:1198662 ZFAND2A -0.54 -8.16 -0.45 1.39e-14 Longevity;Endometriosis; CESC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg04267008 chr7:1944627 MAD1L1 -0.57 -6.89 -0.39 4.08e-11 Bipolar disorder and schizophrenia; CESC cis rs10056811 0.556 rs57441318 chr5:74379675 T/A cg03227963 chr5:74354835 NA 0.31 5.07 0.3 7.41e-7 Coronary artery disease; CESC cis rs7680126 0.595 rs17251963 chr4:10142561 A/G cg11266682 chr4:10021025 SLC2A9 -0.43 -5.5 -0.32 9.1e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs9611565 0.765 rs132907 chr22:41801268 A/C cg03806693 chr22:41940476 POLR3H 1.09 12.57 0.61 9.68e-29 Vitiligo; CESC cis rs11249608 0.548 rs2132671 chr5:178457434 A/G cg01312482 chr5:178451176 ZNF879 0.46 6.4 0.37 7.07e-10 Pubertal anthropometrics; CESC cis rs7662987 0.517 rs1133485 chr4:100023811 T/A cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.21e-14 Smoking initiation; CESC cis rs2991971 0.747 rs2492841 chr1:45894891 G/T cg24296786 chr1:45957014 TESK2 -0.59 -8.09 -0.44 2.2e-14 High light scatter reticulocyte count; CESC cis rs1371867 0.810 rs3020182 chr8:101233008 T/C cg11906718 chr8:101322791 RNF19A -0.48 -5.91 -0.34 1.07e-8 Atrioventricular conduction; CESC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg26850624 chr5:429559 AHRR -0.48 -6.63 -0.38 1.85e-10 Cystic fibrosis severity; CESC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.33e-8 Total body bone mineral density; CESC cis rs4132509 0.744 rs7519673 chr1:243993123 A/G cg21452805 chr1:244014465 NA 0.66 7.16 0.4 7.89e-12 RR interval (heart rate); CESC cis rs7223966 1.000 rs7217982 chr17:61832150 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.67 0.38 1.48e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9815354 0.812 rs73073361 chr3:41842926 C/G cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs554111 0.660 rs667687 chr1:21072577 A/G cg04902671 chr1:21058625 SH2D5 -0.42 -5.19 -0.3 4.27e-7 Facial morphology (factor 17, height of vermillion upper lip); CESC cis rs2235642 0.893 rs2076442 chr16:1591112 G/T cg10465839 chr16:1584050 IFT140;TMEM204 -0.34 -5.48 -0.32 9.76e-8 Coronary artery disease; CESC cis rs561341 0.714 rs7218466 chr17:30263314 A/G cg13647721 chr17:30228624 UTP6 0.52 5.27 0.31 2.81e-7 Hip circumference adjusted for BMI; CESC cis rs6815814 0.731 rs4504266 chr4:38773754 G/A cg02016764 chr4:38805732 TLR1 -0.44 -6.08 -0.35 4.24e-9 Breast cancer; CESC cis rs854765 0.647 rs2056842 chr17:18009028 C/T cg04398451 chr17:18023971 MYO15A -0.82 -12.2 -0.6 1.77e-27 Total body bone mineral density; CESC cis rs6570726 0.934 rs430003 chr6:145819506 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg18252515 chr7:66147081 NA -0.47 -6.11 -0.35 3.53e-9 Aortic root size; CESC trans rs9325144 0.624 rs10783329 chr12:39113951 C/T cg23762105 chr12:34175262 ALG10 0.47 6.12 0.35 3.31e-9 Morning vs. evening chronotype; CESC cis rs3892630 0.878 rs8108621 chr19:33183291 G/A cg22980127 chr19:33182716 NUDT19 1.02 11.59 0.58 2.11e-25 Red blood cell traits; CESC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg11890956 chr21:40555474 PSMG1 1.08 16.87 0.72 7e-44 Cognitive function; CESC cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg03467027 chr4:99064603 C4orf37 0.48 5.95 0.34 8.67e-9 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11073833 chr1:153936127 SLC39A1 -0.46 -6.56 -0.37 2.89e-10 Gambling; CESC cis rs10791097 0.608 rs12363140 chr11:130744268 A/C cg12179176 chr11:130786555 SNX19 0.65 10.05 0.53 2.42e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2066819 1.000 rs35526714 chr12:56634639 G/C cg26714650 chr12:56694279 CS -1.56 -9.55 -0.51 8.89e-19 Psoriasis vulgaris; CESC cis rs3091242 0.809 rs660129 chr1:25727438 C/T cg03538708 chr1:25844672 NA -0.4 -5.98 -0.34 7.38e-9 Erythrocyte sedimentation rate; CESC cis rs6120849 0.754 rs6088686 chr20:33623437 C/T cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs7818688 0.697 rs28399553 chr8:95906794 A/G cg16049864 chr8:95962084 TP53INP1 0.56 5.46 0.32 1.11e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs17253792 0.822 rs74935793 chr14:56143277 G/A cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.6 0.33 5.26e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs447 0.887 rs6467988 chr7:83756500 C/T cg22846510 chr7:83753280 SEMA3A -0.44 -5.38 -0.31 1.64e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg15145296 chr3:125709740 NA -0.52 -5.47 -0.32 1.06e-7 Blood pressure (smoking interaction); CESC cis rs9888739 1.000 rs36055763 chr16:31299775 C/T cg15817542 chr16:31343056 ITGAM -0.46 -5.2 -0.3 3.95e-7 Systemic lupus erythematosus; CESC cis rs9612 0.950 rs60649310 chr19:44269241 A/G cg08581076 chr19:44259116 C19orf61 0.48 5.72 0.33 2.84e-8 Exhaled nitric oxide output; CESC trans rs2727020 0.658 rs4980440 chr11:49386017 C/T cg15704280 chr7:45808275 SEPT13 -0.91 -15.84 -0.7 3.2e-40 Coronary artery disease; CESC cis rs910316 0.763 rs1548807 chr14:75479582 T/G cg11812906 chr14:75593930 NEK9 0.78 12.56 0.61 1.1e-28 Height; CESC cis rs10504229 0.817 rs55891651 chr8:58167600 C/T cg22535103 chr8:58192502 C8orf71 -0.84 -11.02 -0.56 1.76e-23 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04117832 chr2:152685230 ARL5A 0.54 6.43 0.37 5.83e-10 Gut microbiome composition (summer); CESC cis rs7640424 0.649 rs13093976 chr3:107864963 A/C cg09227934 chr3:107805635 CD47 0.41 5.49 0.32 9.59e-8 Body mass index; CESC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg09658497 chr7:2847517 GNA12 -0.38 -5.43 -0.32 1.31e-7 Height; CESC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg22029157 chr1:209979665 IRF6 -0.55 -8.54 -0.46 1.05e-15 Orofacial clefts; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00630453 chr20:2821369 FAM113A;VPS16 0.46 6.12 0.35 3.34e-9 Systemic lupus erythematosus; CESC trans rs1814175 0.645 rs847630 chr11:49926360 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC trans rs12310956 0.532 rs10844715 chr12:33968444 A/G cg26384229 chr12:38710491 ALG10B 0.45 6.39 0.37 7.33e-10 Morning vs. evening chronotype; CESC trans rs12478296 1.000 rs7420157 chr2:243005204 G/A cg18288967 chr1:45987694 PRDX1 0.59 6.55 0.37 2.96e-10 Obesity-related traits; CESC cis rs1801251 0.893 rs11687128 chr2:233608901 T/C cg08000102 chr2:233561755 GIGYF2 0.66 9.34 0.5 4.05e-18 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15336778 chr2:32853064 TTC27 0.46 6.15 0.35 2.79e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg13770153 chr20:60521292 NA -0.5 -6.53 -0.37 3.31e-10 Body mass index; CESC cis rs950776 0.518 rs12910100 chr15:78822667 C/T cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs6061231 0.793 rs2427320 chr20:60976723 A/G cg22601191 chr20:60968625 CABLES2 0.53 6.48 0.37 4.55e-10 Colorectal cancer; CESC cis rs6502050 0.814 rs9894554 chr17:80073423 C/G cg23985595 chr17:80112537 CCDC57 0.41 6.38 0.36 7.8e-10 Life satisfaction; CESC cis rs7512552 0.839 rs11590787 chr1:150398531 G/A cg15654264 chr1:150340011 RPRD2 0.4 5.3 0.31 2.4e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -8.13 -0.45 1.7e-14 Alzheimer's disease; CESC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg05564831 chr3:52568323 NT5DC2 0.46 6.94 0.39 2.93e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22435810 chr17:18164253 SMCR7 0.68 7.66 0.43 3.42e-13 Gut microbiome composition (summer); CESC cis rs662064 0.962 rs660725 chr1:10557544 A/G cg20482658 chr1:10539492 PEX14 -0.36 -7.09 -0.4 1.24e-11 Asthma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11592951 chr7:100472745 SRRT -0.49 -6.6 -0.38 2.19e-10 Fibrinogen levels; CESC cis rs3780486 0.801 rs3780495 chr9:33125942 A/C cg13443165 chr9:33130375 B4GALT1 0.47 6.79 0.39 7.28e-11 IgG glycosylation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03689283 chr3:196668656 NCBP2;LOC152217 0.53 6.99 0.39 2.27e-11 Gut microbiota (bacterial taxa); CESC cis rs116095464 0.558 rs62344345 chr5:257420 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.28 0.31 2.76e-7 Breast cancer; CESC cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg24308560 chr3:49941425 MST1R -0.63 -9.02 -0.48 3.95e-17 Intelligence (multi-trait analysis); CESC trans rs4950322 0.580 rs1813002 chr1:146584161 C/G cg04954894 chr8:38089920 DDHD2 -0.58 -6.28 -0.36 1.4e-9 Protein quantitative trait loci; CESC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg11764359 chr7:65958608 NA 0.73 10.55 0.54 5.73e-22 Aortic root size; CESC cis rs9457247 0.534 rs9356551 chr6:167400345 T/C cg25258033 chr6:167368657 RNASET2 -0.37 -5.44 -0.32 1.2e-7 Crohn's disease; CESC cis rs2243480 0.803 rs35268390 chr7:65416536 C/G cg25894440 chr7:65020034 NA -0.59 -5.23 -0.31 3.41e-7 Diabetic kidney disease; CESC cis rs2115630 0.645 rs6496284 chr15:85178270 A/G cg11189052 chr15:85197271 WDR73 -0.51 -6.78 -0.38 7.61e-11 P wave terminal force; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15503098 chr1:184723524 EDEM3 0.59 6.54 0.37 3.23e-10 Gut microbiome composition (summer); CESC cis rs2635047 0.638 rs2571002 chr18:44665052 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 5.38 0.31 1.61e-7 Educational attainment; CESC cis rs854765 0.647 rs62073573 chr17:17976354 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.45 5.63 0.33 4.53e-8 Total body bone mineral density; CESC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.61 0.81 8.52e-64 Prudent dietary pattern; CESC cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6089584 1.000 rs6089581 chr20:60562394 G/A cg24733560 chr20:60626293 TAF4 0.4 5.77 0.33 2.15e-8 Body mass index; CESC cis rs4973397 0.765 rs13030174 chr2:232271284 A/C cg09339159 chr2:232260559 B3GNT7 0.51 5.22 0.31 3.56e-7 Anti-saccade response; CESC cis rs2354432 0.607 rs12402309 chr1:146721983 T/A cg25205988 chr1:146714368 CHD1L -1.03 -8.98 -0.48 5.06e-17 Mitochondrial DNA levels; CESC cis rs72945132 0.882 rs12099016 chr11:70195161 C/G cg14191688 chr11:70257035 CTTN 0.41 5.13 0.3 5.6e-7 Coronary artery disease; CESC cis rs1881797 1.000 rs1881797 chr1:247689532 A/G cg18198730 chr1:247681584 NA 0.56 8.31 0.45 5.01e-15 Acute lymphoblastic leukemia (childhood); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14684917 chr11:62380363 EML3;ROM1 0.59 6.84 0.39 5.61e-11 Gut microbiome composition (summer); CESC trans rs60843830 0.550 rs300751 chr2:209063 A/C cg06230206 chr11:126456119 KIRREL3 0.37 6.63 0.38 1.85e-10 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs72781680 0.611 rs55868657 chr2:24295385 G/A cg08917208 chr2:24149416 ATAD2B 0.55 5.22 0.31 3.56e-7 Lymphocyte counts; CESC cis rs818427 0.593 rs448613 chr5:112210966 T/C cg07820702 chr5:112228657 REEP5 0.41 5.42 0.32 1.35e-7 Total body bone mineral density; CESC cis rs9457247 0.663 rs2237274 chr6:167442995 C/G cg23791538 chr6:167370224 RNASET2 -0.57 -7.7 -0.43 2.73e-13 Crohn's disease; CESC cis rs9916302 0.904 rs11078897 chr17:37415870 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.07 -0.56 1.19e-23 Glomerular filtration rate (creatinine); CESC cis rs1707322 1.000 rs4660903 chr1:46457601 A/G cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1957429 0.808 rs6573581 chr14:65331955 G/A cg23373153 chr14:65346875 NA 0.88 9.2 0.49 1.13e-17 Pediatric areal bone mineral density (radius); CESC cis rs59918340 0.738 rs3739235 chr8:142229145 A/G cg23750338 chr8:142222470 SLC45A4 0.62 9.26 0.49 7.03e-18 Immature fraction of reticulocytes; CESC cis rs1538970 0.851 rs61788285 chr1:45919234 A/C cg06784218 chr1:46089804 CCDC17 0.35 5.52 0.32 8.19e-8 Platelet count; CESC cis rs11122272 0.668 rs2472261 chr1:231505701 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -6.53 -0.37 3.26e-10 Hemoglobin concentration; CESC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs9894429 0.816 rs7406040 chr17:79597583 A/C cg18240062 chr17:79603768 NPLOC4 0.9 13.2 0.63 6.66e-31 Eye color traits; CESC cis rs17376456 1.000 rs61132622 chr5:93539684 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.21 0.3 3.8e-7 Diabetic retinopathy; CESC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.68 -0.51 3.46e-19 Alzheimer's disease; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg00814883 chr7:100076585 TSC22D4 -0.46 -6.08 -0.35 4.29e-9 Recombination measurement; CESC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg18446336 chr7:2847575 GNA12 -0.37 -5.63 -0.33 4.5e-8 Height; CESC cis rs6541297 0.703 rs671682 chr1:230313651 C/G cg20703242 chr1:230279135 GALNT2 -0.43 -5.6 -0.33 5.46e-8 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23603076 chr14:24605279 PSME1 -0.46 -6.26 -0.36 1.54e-9 Fibrinogen levels; CESC cis rs425277 1.000 rs262654 chr1:2089526 G/A cg04315214 chr1:2043799 PRKCZ -0.39 -5.37 -0.31 1.72e-7 Height; CESC cis rs6570726 0.905 rs406799 chr6:145821837 G/C cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs73206853 0.764 rs56273026 chr12:110901691 A/C cg12870014 chr12:110450643 ANKRD13A 0.62 5.15 0.3 5.18e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs9596009 0.591 rs9595995 chr13:49340625 T/G cg13176070 chr2:32503943 YIPF4 0.52 6.08 0.35 4.25e-9 Cough in response to angiotensin-converting enzyme inhibitor drugs; CESC cis rs2235544 0.664 rs55766128 chr1:54477726 T/G cg09175620 chr1:54484536 LDLRAD1 -0.29 -5.09 -0.3 6.64e-7 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg07157834 chr1:205819609 PM20D1 0.79 12.97 0.62 4.05e-30 Menarche (age at onset); CESC cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg01579765 chr21:45077557 HSF2BP -0.54 -9.03 -0.49 3.52e-17 Mean corpuscular volume; CESC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg03351412 chr1:154909251 PMVK 0.68 9.09 0.49 2.37e-17 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26996458 chr8:141636297 EIF2C2 0.43 6.0 0.35 6.38e-9 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11614198 chr11:47364636 MYBPC3 0.44 6.18 0.35 2.35e-9 Fibrinogen levels; CESC cis rs11583043 0.708 rs1060481 chr1:101546699 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.44 0.32 1.21e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs3204270 0.714 rs79243595 chr17:79681220 T/C cg18367735 chr17:79674897 NA 0.74 6.62 0.38 1.99e-10 Dental caries; CESC cis rs950169 0.959 rs66801143 chr15:84736657 C/T cg17507749 chr15:85114479 UBE2QP1 0.64 7.1 0.4 1.17e-11 Schizophrenia; CESC cis rs933688 0.532 rs997737 chr5:90567031 C/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.43 -5.08 -0.3 7.06e-7 Smoking behavior; CESC trans rs3749237 0.964 rs1799843 chr3:49849723 G/A cg21659725 chr3:3221576 CRBN 0.53 6.38 0.36 8.01e-10 Resting heart rate; CESC trans rs7980799 0.682 rs4931719 chr12:33602986 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.03 -0.44 3.21e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs6598955 1.000 rs6598955 chr1:26619649 C/T cg04990556 chr1:26633338 UBXN11 0.81 10.86 0.55 5.7e-23 Obesity-related traits; CESC cis rs8017423 0.967 rs7147809 chr14:90715025 A/G cg14092571 chr14:90743983 NA -0.58 -8.72 -0.47 3.01e-16 Mortality in heart failure; CESC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.49 -0.37 4.09e-10 Developmental language disorder (linguistic errors); CESC cis rs2797160 0.904 rs1739366 chr6:126007409 T/C cg05901451 chr6:126070800 HEY2 0.46 6.48 0.37 4.35e-10 Endometrial cancer; CESC cis rs8060686 0.641 rs79577483 chr16:68036939 A/G cg26727032 chr16:67993705 SLC12A4 -0.51 -5.88 -0.34 1.25e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg10691866 chr7:65817282 TPST1 0.31 5.32 0.31 2.25e-7 Aortic root size; CESC trans rs629535 0.859 rs55803226 chr8:70108965 T/C cg21567404 chr3:27674614 NA -0.88 -10.23 -0.53 6.38e-21 Dupuytren's disease; CESC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12843872 chr7:90894352 FZD1 0.5 6.61 0.38 2.13e-10 Gut microbiota (bacterial taxa); CESC cis rs367943 0.966 rs348947 chr5:112822795 C/G cg12552261 chr5:112820674 MCC -0.63 -7.96 -0.44 4.96e-14 Type 2 diabetes; CESC cis rs8077889 0.917 rs4793037 chr17:41914826 C/T cg26893861 chr17:41843967 DUSP3 0.84 10.56 0.54 5.63e-22 Triglycerides; CESC cis rs4523957 0.890 rs2281727 chr17:2117945 A/G cg16513277 chr17:2031491 SMG6 -0.63 -8.71 -0.47 3.39e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13457403 chr21:44313401 NDUFV3 0.57 6.48 0.37 4.34e-10 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14056620 chr7:44836144 PPIA -0.49 -6.2 -0.36 2.12e-9 Ulcerative colitis; CESC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg06212747 chr3:49208901 KLHDC8B 0.53 7.21 0.4 5.95e-12 Parkinson's disease; CESC cis rs9902453 0.904 rs4077465 chr17:28300144 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.99 0.48 4.87e-17 Coffee consumption (cups per day); CESC cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg12641515 chr19:46296257 DMWD -0.52 -5.77 -0.33 2.22e-8 Coronary artery disease; CESC cis rs2777491 0.915 rs8032838 chr15:41605632 G/A cg02330683 chr15:41787940 ITPKA 0.45 6.56 0.37 2.73e-10 Ulcerative colitis; CESC cis rs9300255 0.602 rs1790098 chr12:123655481 A/C cg05973401 chr12:123451056 ABCB9 0.54 6.04 0.35 5.31e-9 Neutrophil percentage of white cells; CESC cis rs7808935 0.628 rs12666447 chr7:27937267 C/T cg05786569 chr7:27702416 HIBADH 0.53 5.83 0.34 1.58e-8 Prostate cancer; CESC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg19046167 chr17:80928561 B3GNTL1 0.48 5.72 0.33 2.84e-8 Glycated hemoglobin levels; CESC trans rs4843747 0.518 rs4072777 chr16:88107030 G/A cg26811252 chr16:29126840 RRN3P2 0.67 9.46 0.5 1.77e-18 Menopause (age at onset); CESC cis rs12142240 0.731 rs6658556 chr1:46844180 A/C cg10495392 chr1:46806563 NSUN4 0.55 5.94 0.34 9.08e-9 Menopause (age at onset); CESC cis rs2652822 0.555 rs77171305 chr15:63536230 C/A cg02713581 chr15:63449717 RPS27L 0.49 6.16 0.35 2.69e-9 Metabolic traits; CESC cis rs55788414 0.932 rs59201365 chr16:81185681 C/G cg06400318 chr16:81190750 PKD1L2 -0.57 -6.53 -0.37 3.31e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 10.82 0.55 7.72e-23 Platelet count; CESC cis rs9611565 0.694 rs79008 chr22:41850500 C/T cg17376030 chr22:41985996 PMM1 0.73 8.03 0.44 3.14e-14 Vitiligo; CESC cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg05347473 chr6:146136440 FBXO30 -0.55 -6.66 -0.38 1.6e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6088590 1.000 rs6119516 chr20:33328024 C/T cg24642439 chr20:33292090 TP53INP2 0.83 11.67 0.58 1.1e-25 Coronary artery disease; CESC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg23161317 chr6:28129485 ZNF389 0.4 5.72 0.33 2.81e-8 Cardiac Troponin-T levels; CESC cis rs698761 0.519 rs10427177 chr2:44510179 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.52 5.08 0.3 7.25e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs11190604 0.943 rs11190581 chr10:102243387 T/G cg07080220 chr10:102295463 HIF1AN 0.55 5.44 0.32 1.21e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 10.05 0.53 2.43e-20 Alzheimer's disease; CESC cis rs910316 0.763 rs2080201 chr14:75629972 C/T cg08847533 chr14:75593920 NEK9 -0.87 -14.36 -0.66 5.69e-35 Height; CESC cis rs67311347 0.911 rs6773917 chr3:40469254 G/T cg09455208 chr3:40491958 NA 0.43 7.34 0.41 2.65e-12 Renal cell carcinoma; CESC cis rs6500395 1.000 rs7197732 chr16:48575878 G/A cg04672837 chr16:48644449 N4BP1 0.45 5.4 0.31 1.51e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1413885 0.516 rs9326063 chr1:65835911 T/C cg14976592 chr1:65886160 LEPROT;LEPR 0.46 5.97 0.34 7.68e-9 Anticoagulant levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15247144 chr16:31213730 PYCARD 0.48 6.06 0.35 4.69e-9 Gut microbiota (bacterial taxa); CESC cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg27286337 chr10:134555280 INPP5A 0.91 14.94 0.68 4.94e-37 Migraine; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06722069 chr3:113822382 NA -0.62 -7.26 -0.41 4.23e-12 Gut microbiome composition (summer); CESC trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg03929089 chr4:120376271 NA 0.72 9.89 0.52 7.86e-20 Coronary artery disease; CESC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg12648201 chr2:27665141 KRTCAP3 -0.33 -6.08 -0.35 4.17e-9 Total body bone mineral density; CESC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg06138931 chr13:21896616 NA 0.56 7.72 0.43 2.36e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2295499 0.643 rs35424748 chr4:2669054 T/C cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.12 -0.3 5.78e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs447735 0.587 rs258336 chr16:89720831 A/C cg04240660 chr16:89714849 CHMP1A -0.37 -5.08 -0.3 7.25e-7 Hemoglobin concentration; CESC trans rs7726839 0.526 rs55647623 chr5:567747 T/C cg25482853 chr8:67687455 SGK3 0.95 10.36 0.54 2.45e-21 Obesity-related traits; CESC cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg06212747 chr3:49208901 KLHDC8B 0.68 9.35 0.5 3.77e-18 Parkinson's disease; CESC cis rs523522 0.962 rs4766968 chr12:120947788 G/C cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg12963246 chr6:28129442 ZNF389 0.57 7.78 0.43 1.65e-13 Parkinson's disease; CESC cis rs2742234 0.590 rs2293020 chr10:43692887 A/G cg15436174 chr10:43711423 RASGEF1A 0.46 5.31 0.31 2.31e-7 Hirschsprung disease; CESC cis rs847577 0.722 rs7790120 chr7:97712831 C/A cg24562669 chr7:97807699 LMTK2 0.63 10.27 0.53 4.67e-21 Breast cancer; CESC cis rs7680126 0.632 rs6834645 chr4:10150174 G/A cg11266682 chr4:10021025 SLC2A9 -0.52 -6.56 -0.37 2.77e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs727505 1.000 rs28702851 chr7:124442991 G/A cg23710748 chr7:124431027 NA -0.47 -7.22 -0.41 5.56e-12 Lewy body disease; CESC cis rs4595586 1.000 rs1523118 chr12:39229699 C/T cg26384229 chr12:38710491 ALG10B -0.38 -5.31 -0.31 2.35e-7 Morning vs. evening chronotype; CESC cis rs1577917 0.958 rs11755048 chr6:86514334 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -6.47 -0.37 4.58e-10 Response to antipsychotic treatment; CESC cis rs9837602 0.529 rs793494 chr3:99508768 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.59 -9.56 -0.51 8.49e-19 Breast cancer; CESC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg26314531 chr2:26401878 FAM59B -0.61 -6.93 -0.39 3.18e-11 Gut microbiome composition (summer); CESC cis rs7647973 1.000 rs13322887 chr3:49555583 G/A cg06212747 chr3:49208901 KLHDC8B -0.6 -7.97 -0.44 4.76e-14 Menarche (age at onset); CESC cis rs3845702 1.000 rs3738943 chr2:180846743 G/T cg01881094 chr2:180872142 CWC22 -0.64 -6.78 -0.38 7.99e-11 Schizophrenia; CESC cis rs12900413 0.687 rs12903462 chr15:90304075 C/T cg24249390 chr15:90295951 MESP1 -0.41 -5.63 -0.33 4.5e-8 Coronary artery aneurysm in Kawasaki disease; CESC trans rs8014204 0.816 rs28426374 chr14:75346740 C/T cg22117143 chr9:13251431 MPDZ 0.38 6.01 0.35 6.09e-9 Caffeine consumption; CESC cis rs208520 0.754 rs851593 chr6:66875783 C/T cg07460842 chr6:66804631 NA 1.01 12.99 0.62 3.45e-30 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12699174 chr1:156024477 ROBLD3;UBQLN4 0.56 6.01 0.35 6.08e-9 Gut microbiome composition (summer); CESC cis rs4237845 0.537 rs2002275 chr12:58283385 A/G cg02175503 chr12:58329896 NA 0.46 5.72 0.33 2.87e-8 Intelligence (multi-trait analysis); CESC cis rs13095912 1.000 rs35497918 chr3:185310312 C/T cg11274856 chr3:185301563 NA 0.37 6.05 0.35 5.02e-9 Systolic blood pressure; CESC cis rs6011002 1.000 rs75897888 chr20:62303558 C/G cg15212369 chr20:62274085 STMN3 -0.57 -5.16 -0.3 4.82e-7 Dental caries; CESC cis rs2228479 0.717 rs1007932 chr16:89838541 C/T cg04013166 chr16:89971882 TCF25 0.79 8.18 0.45 1.21e-14 Skin colour saturation; CESC trans rs3942852 0.568 rs2904315 chr11:48109948 C/T cg03929089 chr4:120376271 NA 0.68 8.4 0.46 2.68e-15 Acute lymphoblastic leukemia (childhood); CESC cis rs6433857 0.536 rs12464424 chr2:181349137 A/G cg23363182 chr2:181467187 NA -0.4 -5.85 -0.34 1.43e-8 Body mass index; CESC cis rs6500395 1.000 rs7201196 chr16:48674030 C/T cg04672837 chr16:48644449 N4BP1 0.51 6.31 0.36 1.16e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7089973 0.604 rs7904188 chr10:116610271 G/C cg25233709 chr10:116636983 FAM160B1 0.38 6.08 0.35 4.13e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg06808227 chr14:105710500 BRF1 -0.6 -6.93 -0.39 3.25e-11 Mean platelet volume;Platelet distribution width; CESC cis rs6696846 0.729 rs72757512 chr1:205079203 G/A cg00857998 chr1:205179979 DSTYK 0.54 7.21 0.41 5.81e-12 Red blood cell count; CESC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg07870213 chr5:140052090 DND1 0.63 6.73 0.38 1.05e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.69 0.33 3.39e-8 Bipolar disorder; CESC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg06420487 chr17:61919686 SMARCD2 0.46 5.52 0.32 8.05e-8 Height; CESC cis rs7826238 0.653 rs2979202 chr8:8344127 T/C cg15556689 chr8:8085844 FLJ10661 0.51 6.31 0.36 1.18e-9 Systolic blood pressure; CESC cis rs4148883 0.504 rs2000864 chr4:100123776 A/C cg12011299 chr4:100065546 ADH4 0.48 6.65 0.38 1.71e-10 Alcohol dependence; CESC cis rs2011503 0.882 rs72999030 chr19:19364240 A/T cg20644253 chr19:19431407 KIAA0892;SF4 0.54 5.73 0.33 2.76e-8 Bipolar disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12477012 chr1:46049214 NASP 0.5 6.27 0.36 1.46e-9 Gut microbiota (bacterial taxa); CESC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg00684032 chr4:1343700 KIAA1530 0.36 5.4 0.31 1.49e-7 Obesity-related traits; CESC cis rs4237845 0.537 rs12312955 chr12:58265223 A/G cg00677455 chr12:58241039 CTDSP2 0.78 10.45 0.54 1.23e-21 Intelligence (multi-trait analysis); CESC cis rs9611565 0.625 rs12483991 chr22:41935285 A/G cg17376030 chr22:41985996 PMM1 0.49 5.66 0.33 3.98e-8 Vitiligo; CESC cis rs4595586 0.545 rs1356265 chr12:39403696 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.66 0.43 3.57e-13 Morning vs. evening chronotype; CESC cis rs2415984 0.579 rs754962 chr14:46962719 T/C cg14871534 chr14:47121158 RPL10L 0.35 5.32 0.31 2.24e-7 Number of children ever born; CESC cis rs8180040 0.726 rs4682837 chr3:46999707 C/T cg27129171 chr3:47204927 SETD2 0.67 9.74 0.51 2.32e-19 Colorectal cancer; CESC cis rs897984 0.568 rs67264578 chr16:30879395 G/A cg02466173 chr16:30829666 NA -0.47 -6.87 -0.39 4.6e-11 Dementia with Lewy bodies; CESC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg11663144 chr21:46675770 NA -0.62 -9.72 -0.51 2.66e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7937682 0.889 rs3017767 chr11:111508098 A/G cg22437258 chr11:111473054 SIK2 0.7 9.35 0.5 3.83e-18 Primary sclerosing cholangitis; CESC cis rs72781680 0.898 rs72796154 chr2:23933839 G/A cg20701182 chr2:24300061 SF3B14 0.77 6.82 0.39 6.04e-11 Lymphocyte counts; CESC trans rs9858542 0.953 rs35115732 chr3:49475155 T/C cg21659725 chr3:3221576 CRBN -0.56 -6.63 -0.38 1.86e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs28374715 0.681 rs8037574 chr15:41630770 T/C cg20272979 chr15:41787780 ITPKA 0.39 5.21 0.3 3.76e-7 Ulcerative colitis; CESC cis rs11190604 1.000 rs9420797 chr10:102331147 C/T cg07080220 chr10:102295463 HIF1AN 0.59 6.1 0.35 3.84e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs1355223 0.583 rs2956076 chr11:34874124 T/C cg11058730 chr11:34937778 PDHX;APIP 0.82 12.46 0.61 2.34e-28 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg17971929 chr21:40555470 PSMG1 1.04 16.44 0.71 2.36e-42 Cognitive function; CESC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg22081084 chr1:89990230 LRRC8B -0.44 -6.05 -0.35 5.01e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs5769765 0.773 rs7290751 chr22:50318312 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.63 -6.42 -0.37 6.2e-10 Schizophrenia; CESC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg08888203 chr3:10149979 C3orf24 0.44 5.71 0.33 3.09e-8 Alzheimer's disease; CESC trans rs7088591 0.867 rs58666115 chr10:59735805 C/G cg10559231 chr5:14188039 TRIO 0.76 6.28 0.36 1.35e-9 Blood pressure; CESC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg11301795 chr4:187892539 NA -0.75 -12.51 -0.61 1.63e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs963731 0.649 rs6725356 chr2:39238395 C/G cg04010122 chr2:39346883 SOS1 0.75 5.75 0.33 2.51e-8 Corticobasal degeneration; CESC cis rs60154123 0.554 rs1338290 chr1:210465467 G/A cg22029157 chr1:209979665 IRF6 0.5 5.92 0.34 9.68e-9 Coronary artery disease; CESC cis rs2109514 0.585 rs3779512 chr7:116171063 T/G cg04696780 chr7:116139425 CAV2 -0.32 -5.81 -0.34 1.8e-8 Prevalent atrial fibrillation; CESC cis rs2000999 0.778 rs12445401 chr16:72148419 A/G cg16558253 chr16:72132732 DHX38 -0.54 -6.58 -0.37 2.53e-10 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC cis rs7656342 0.622 rs10009838 chr4:9833882 G/A cg00071950 chr4:10020882 SLC2A9 0.4 5.4 0.31 1.49e-7 Gut microbiota (bacterial taxa); CESC cis rs1707322 0.964 rs1768802 chr1:46547868 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.57 -0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3741404 0.665 rs594461 chr11:63872543 A/G cg18225595 chr11:63971243 STIP1 0.52 6.76 0.38 8.53e-11 Platelet count; CESC cis rs9522267 0.535 rs11069898 chr13:112231512 C/T cg10483660 chr13:112241077 NA -0.33 -5.83 -0.34 1.65e-8 Hepatitis; CESC cis rs2243480 1.000 rs6970243 chr7:65388490 C/A cg12463550 chr7:65579703 CRCP 0.7 5.58 0.32 5.87e-8 Diabetic kidney disease; CESC cis rs7953249 0.656 rs2251468 chr12:121405126 A/C cg25281562 chr12:121454272 C12orf43 0.45 5.64 0.33 4.35e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs34375054 0.526 rs2343638 chr12:125677122 G/C cg05341575 chr12:125625032 AACS -0.36 -5.23 -0.31 3.51e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs3820068 0.603 rs72645900 chr1:15931980 A/T cg13390004 chr1:15929781 NA 0.34 5.45 0.32 1.13e-7 Systolic blood pressure; CESC cis rs959260 1.000 rs9900002 chr17:73382018 T/A cg12999837 chr17:73267436 MIF4GD -0.48 -5.58 -0.32 5.89e-8 Systemic lupus erythematosus; CESC trans rs66573146 1.000 rs6812391 chr4:6963893 G/A cg07817883 chr1:32538562 TMEM39B 1.51 9.21 0.49 1.06e-17 Granulocyte percentage of myeloid white cells; CESC cis rs11785400 1.000 rs4297023 chr8:143733307 C/A cg10596483 chr8:143751796 JRK 0.42 5.53 0.32 7.59e-8 Schizophrenia; CESC cis rs7259376 0.934 rs7253315 chr19:22594439 C/T cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.94e-7 Menopause (age at onset); CESC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs11792861 0.888 rs72607168 chr9:111832192 G/C cg13535736 chr9:111863775 C9orf5 -0.51 -6.84 -0.39 5.58e-11 Menarche (age at onset); CESC cis rs71335811 1 rs71335811 chr19:49130070 TC/T cg06677660 chr19:49140777 SEC1;DBP -0.43 -5.27 -0.31 2.9e-7 Myeloid white cell count; CESC cis rs79057730 0.599 rs4721086 chr7:821123 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.73 6.83 0.39 5.78e-11 Initial pursuit acceleration; CESC cis rs950173 1.000 rs13000153 chr2:172586067 A/G cg13550731 chr2:172543902 DYNC1I2 -0.87 -6.48 -0.37 4.53e-10 Hippocampal volume; CESC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg24733560 chr20:60626293 TAF4 0.38 5.46 0.32 1.09e-7 Body mass index; CESC cis rs208520 0.690 rs1738970 chr6:66809491 T/G cg07460842 chr6:66804631 NA -0.98 -13.32 -0.63 2.47e-31 Exhaled nitric oxide output; CESC cis rs61931739 0.890 rs1705753 chr12:34144594 C/T cg19457237 chr12:34500585 NA -0.36 -5.06 -0.3 7.79e-7 Morning vs. evening chronotype; CESC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg09658497 chr7:2847517 GNA12 -0.42 -5.81 -0.34 1.81e-8 Height; CESC cis rs899997 0.862 rs11072787 chr15:78972977 T/C cg04896959 chr15:78267971 NA -0.36 -5.23 -0.31 3.47e-7 Coronary artery disease or large artery stroke; CESC cis rs2439831 1.000 rs2256764 chr15:43735763 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.8 9.98 0.52 4.07e-20 Lung cancer in ever smokers; CESC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg19592336 chr6:28129416 ZNF389 -0.53 -7.22 -0.41 5.6e-12 Depression; CESC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg18451016 chr1:38461880 NA 0.42 6.4 0.37 6.9e-10 Coronary artery disease; CESC cis rs9911578 0.935 rs9893351 chr17:57023326 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.38 5.05 0.3 8.18e-7 Intelligence (multi-trait analysis); CESC cis rs17486696 0.655 rs62352418 chr4:165680688 T/C cg01215651 chr4:165675138 NA 0.63 6.64 0.38 1.8e-10 Positive affect; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06310300 chr7:100076089 TSC22D4 -0.46 -6.94 -0.39 2.93e-11 Gambling; CESC cis rs796364 0.806 rs79897806 chr2:201073968 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -5.91 -0.34 1.07e-8 Schizophrenia; CESC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg04025307 chr7:1156635 C7orf50 0.42 5.2 0.3 4.09e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1707322 1.000 rs9793167 chr1:46446800 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Depression; CESC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.62 8.09 0.44 2.22e-14 Prudent dietary pattern; CESC cis rs11098499 0.909 rs10026736 chr4:120384322 G/C cg09307838 chr4:120376055 NA 0.93 12.95 0.62 4.87e-30 Corneal astigmatism; CESC cis rs2180341 0.842 rs9372860 chr6:127546605 G/A cg27446573 chr6:127587934 RNF146 0.94 11.41 0.57 8.78e-25 Breast cancer; CESC cis rs10751667 0.600 rs1128413 chr11:1010694 C/T cg20946044 chr11:1010712 AP2A2 -0.51 -6.73 -0.38 1.06e-10 Alzheimer's disease (late onset); CESC cis rs1062177 1.000 rs12654573 chr5:151207473 T/G cg00977110 chr5:151150581 G3BP1 0.6 6.48 0.37 4.45e-10 Preschool internalizing problems; CESC cis rs2425143 1.000 rs2425093 chr20:34306875 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.75 0.38 9.35e-11 Blood protein levels; CESC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg03709012 chr19:19516395 GATAD2A 1.01 15.89 0.7 2.1e-40 Tonsillectomy; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg06444723 chr6:135376198 HBS1L 0.48 6.47 0.37 4.82e-10 Positive affect; CESC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg04287289 chr16:89883240 FANCA -0.46 -5.64 -0.33 4.4e-8 Vitiligo; CESC cis rs854765 0.583 rs62064158 chr17:17826935 T/C cg16928487 chr17:17741425 SREBF1 -0.57 -9.74 -0.51 2.41e-19 Total body bone mineral density; CESC cis rs28829049 0.597 rs2296107 chr1:19476649 C/G cg13387374 chr1:19411106 UBR4 0.44 5.54 0.32 7.13e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg18876405 chr7:65276391 NA -0.57 -7.75 -0.43 1.97e-13 Aortic root size; CESC cis rs3747547 0.818 rs7027014 chr9:37943571 T/C cg13774184 chr9:37916125 SHB -0.55 -5.56 -0.32 6.53e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14018420 chr1:21766356 NBPF3 0.5 7.21 0.4 5.78e-12 Gut microbiota (bacterial taxa); CESC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.34 -5.45 -0.32 1.17e-7 Cystic fibrosis severity; CESC cis rs2439831 0.867 rs2243434 chr15:43689867 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.86 13.04 0.63 2.26e-30 Lung cancer in ever smokers; CESC cis rs5769707 0.967 rs2187891 chr22:49994094 C/T cg20744362 chr22:50050164 C22orf34 0.43 7.08 0.4 1.31e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs10493773 0.502 rs12061951 chr1:86081453 A/G cg17807903 chr1:86174739 ZNHIT6 -0.43 -5.7 -0.33 3.14e-8 Urate levels in overweight individuals; CESC cis rs10751667 0.666 rs6597958 chr11:978087 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.48e-7 Alzheimer's disease (late onset); CESC cis rs6066835 0.702 rs2073073 chr20:47269537 A/G cg18078177 chr20:47281410 PREX1 0.76 5.19 0.3 4.2e-7 Multiple myeloma; CESC cis rs3008870 0.727 rs2755270 chr1:67474503 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.62 8.04 0.44 3.01e-14 Lymphocyte percentage of white cells; CESC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg05564831 chr3:52568323 NT5DC2 0.43 6.53 0.37 3.32e-10 Bipolar disorder; CESC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.54 5.6 0.33 5.3e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg17372223 chr3:52568218 NT5DC2 0.45 7.43 0.42 1.51e-12 Bipolar disorder; CESC cis rs2243480 1.000 rs35542501 chr7:65431215 T/C cg25894440 chr7:65020034 NA -0.6 -5.31 -0.31 2.38e-7 Diabetic kidney disease; CESC cis rs1215050 0.791 rs503863 chr4:98707663 T/C cg05340658 chr4:99064831 C4orf37 0.5 6.37 0.36 8.34e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9309473 0.607 rs10196402 chr2:73572081 A/C cg20560298 chr2:73613845 ALMS1 -0.47 -6.34 -0.36 9.69e-10 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19881174 chr18:14393244 NA -0.53 -6.37 -0.36 8.4e-10 Gut microbiome composition (summer); CESC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg25767906 chr1:53392781 SCP2 0.51 7.27 0.41 3.98e-12 Monocyte count; CESC cis rs9916302 0.653 rs4239223 chr17:37717004 T/C cg00129232 chr17:37814104 STARD3 -0.55 -5.69 -0.33 3.39e-8 Glomerular filtration rate (creatinine); CESC cis rs360798 0.512 rs360801 chr2:62955387 C/T cg17519650 chr2:63277830 OTX1 0.43 5.43 0.32 1.27e-7 Coronary artery disease; CESC cis rs6496667 0.738 rs5020807 chr15:91043188 C/A cg13834112 chr15:90361639 NA 0.4 5.31 0.31 2.27e-7 Rheumatoid arthritis; CESC cis rs2011503 1.000 rs7252453 chr19:19654117 G/C cg11584989 chr19:19387371 SF4 0.47 5.71 0.33 3.05e-8 Bipolar disorder; CESC cis rs5753618 0.504 rs9609303 chr22:31896309 C/T cg00478049 chr22:31556069 RNF185 -0.44 -5.12 -0.3 5.86e-7 Colorectal cancer; CESC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg05564831 chr3:52568323 NT5DC2 -0.45 -6.87 -0.39 4.49e-11 Bipolar disorder; CESC cis rs2777491 0.915 rs28526381 chr15:41621842 A/C cg18705301 chr15:41695430 NDUFAF1 -0.6 -8.84 -0.48 1.39e-16 Ulcerative colitis; CESC cis rs7818688 0.932 rs6471505 chr8:96028625 G/A cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs12477438 0.520 rs34766932 chr2:99737273 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.92 15.86 0.7 2.85e-40 Chronic sinus infection; CESC cis rs9486719 1.000 rs2263192 chr6:96873037 C/G cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs939658 0.776 rs869672 chr15:79430860 G/A cg17916960 chr15:79447300 NA -0.39 -6.33 -0.36 1.07e-9 Refractive error; CESC cis rs8180040 0.654 rs9837343 chr3:47177388 C/T cg27129171 chr3:47204927 SETD2 0.67 10.16 0.53 1.11e-20 Colorectal cancer; CESC cis rs36051895 0.560 rs1575281 chr9:5219131 T/C cg02405213 chr9:5042618 JAK2 -0.48 -5.65 -0.33 4.09e-8 Pediatric autoimmune diseases; CESC cis rs7551222 0.716 rs7541589 chr1:204542521 G/A cg20240347 chr1:204465584 NA -0.28 -5.64 -0.33 4.38e-8 Schizophrenia; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg20174699 chr12:50222232 LOC100286844;NCKAP5L 0.43 6.02 0.35 5.93e-9 Vertical cup-disc ratio; CESC cis rs2404602 0.669 rs9788684 chr15:77194838 A/T cg26408565 chr15:76604113 ETFA -0.37 -5.36 -0.31 1.79e-7 Blood metabolite levels; CESC cis rs7586879 0.639 rs6722022 chr2:25098859 A/G cg01884057 chr2:25150051 NA 0.38 7.12 0.4 1.02e-11 Body mass index; CESC cis rs2540647 0.706 rs2518805 chr22:18975587 A/G cg12798833 chr22:18958832 DGCR5 0.5 5.45 0.32 1.15e-7 Blood metabolite ratios; CESC cis rs6580649 0.941 rs7296913 chr12:48488920 G/A cg24011408 chr12:48396354 COL2A1 -0.4 -5.05 -0.3 8.15e-7 Lung cancer; CESC cis rs7084402 0.967 rs3001714 chr10:60285494 A/G cg07615347 chr10:60278583 BICC1 0.61 9.69 0.51 3.28e-19 Refractive error; CESC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg06456125 chr7:65229604 NA -0.45 -5.98 -0.34 7.15e-9 Aortic root size; CESC cis rs3733585 0.673 rs4292332 chr4:9953830 C/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6429082 0.846 rs2270538 chr1:235602404 G/A cg26050004 chr1:235667680 B3GALNT2 -0.65 -8.68 -0.47 4.08e-16 Adiposity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25139596 chr2:24270239 C2orf44 0.58 6.5 0.37 3.89e-10 Gut microbiome composition (summer); CESC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg19346786 chr7:2764209 NA -0.49 -7.06 -0.4 1.47e-11 Height; CESC cis rs3733585 0.673 rs4580649 chr4:9948461 G/A cg00071950 chr4:10020882 SLC2A9 -0.73 -11.98 -0.59 9.94e-27 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1461503 0.512 rs3816621 chr11:122818311 A/G cg27398637 chr11:122830231 C11orf63 -0.52 -6.95 -0.39 2.78e-11 Menarche (age at onset); CESC cis rs4268898 0.662 rs9917355 chr2:24433400 C/T cg20701182 chr2:24300061 SF3B14 0.68 7.16 0.4 7.75e-12 Asthma; CESC cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg26818010 chr10:134567672 INPP5A -0.87 -10.61 -0.55 3.9e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg22823121 chr1:150693482 HORMAD1 0.47 6.96 0.39 2.6e-11 Tonsillectomy; CESC cis rs7072216 0.763 rs10748730 chr10:100171440 C/T cg26618903 chr10:100175079 PYROXD2 -0.38 -5.78 -0.33 2.05e-8 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07094487 chr1:46751642 LRRC41 -0.54 -6.35 -0.36 9.25e-10 Gut microbiome composition (summer); CESC cis rs698833 0.819 rs2340810 chr2:44536546 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.51 -6.43 -0.37 6.01e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9929218 0.954 rs12599393 chr16:68829021 C/T cg02972257 chr16:68554789 NA 0.44 5.16 0.3 4.82e-7 Colorectal cancer; CESC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg06456125 chr7:65229604 NA -0.38 -5.22 -0.31 3.56e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18885865 chr14:59655267 DAAM1 -0.49 -6.2 -0.36 2.2e-9 Fibrinogen levels; CESC cis rs9443189 1.000 rs1280044 chr6:76522602 A/G cg01950844 chr6:76311363 SENP6 -0.61 -6.28 -0.36 1.37e-9 Prostate cancer; CESC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg06877462 chr1:205807181 PM20D1 0.39 5.51 0.32 8.32e-8 Menarche (age at onset); CESC cis rs10761750 1 rs10761750 chr10:65128619 G/A cg01631684 chr10:65280961 REEP3 -0.42 -5.17 -0.3 4.55e-7 Vascular endothelial growth factor levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11843188 chr11:102322558 TMEM123 -0.41 -6.25 -0.36 1.62e-9 Gambling; CESC cis rs7249142 0.549 rs2238667 chr19:19282523 G/A cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.28 5.12 0.3 5.99e-7 IgG glycosylation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20150972 chr6:13574573 SIRT5 -0.46 -6.7 -0.38 1.28e-10 Fibrinogen levels; CESC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg24675658 chr1:53192096 ZYG11B -0.55 -7.54 -0.42 7.34e-13 Monocyte count; CESC cis rs12142240 0.738 rs41293277 chr1:46806550 C/T cg10495392 chr1:46806563 NSUN4 0.59 6.36 0.36 8.9e-10 Menopause (age at onset); CESC cis rs2777491 0.574 rs28700583 chr15:41714072 C/T cg20272979 chr15:41787780 ITPKA 0.42 5.18 0.3 4.37e-7 Ulcerative colitis; CESC trans rs1493916 0.905 rs34165207 chr18:31400153 G/A cg27147174 chr7:100797783 AP1S1 -0.54 -7.32 -0.41 3e-12 Life satisfaction; CESC cis rs7927592 0.956 rs7104877 chr11:68377602 G/T cg20283391 chr11:68216788 NA 0.46 5.77 0.33 2.26e-8 Total body bone mineral density; CESC cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg22862634 chr11:62369728 EML3;MTA2 0.6 8.27 0.45 6.45e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg24829409 chr8:58192753 C8orf71 -0.75 -9.72 -0.51 2.74e-19 Developmental language disorder (linguistic errors); CESC cis rs710216 0.957 rs841563 chr1:43429520 C/T cg03128534 chr1:43423976 SLC2A1 0.53 6.13 0.35 3.2e-9 Red cell distribution width; CESC cis rs911555 0.570 rs11625397 chr14:104027557 A/G cg12935359 chr14:103987150 CKB 0.44 6.87 0.39 4.5e-11 Intelligence (multi-trait analysis); CESC trans rs877282 1.000 rs11253362 chr10:770979 G/T cg22713356 chr15:30763199 NA 1.26 12.49 0.61 1.82e-28 Uric acid levels; CESC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg22535103 chr8:58192502 C8orf71 -0.93 -10.32 -0.54 3.27e-21 Developmental language disorder (linguistic errors); CESC cis rs4771122 0.500 rs1049302 chr13:27998769 T/C cg01674679 chr13:27998804 GTF3A 0.58 6.74 0.38 9.69e-11 Body mass index; CESC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg03188948 chr7:1209495 NA 0.57 6.61 0.38 2.06e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg18758796 chr5:131593413 PDLIM4 0.39 5.25 0.31 3.06e-7 Breast cancer; CESC cis rs933688 1.000 rs2059207 chr5:90731931 C/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 11.69 0.58 9.41e-26 Smoking behavior; CESC cis rs2072732 0.861 rs72629493 chr1:2951347 G/A cg03976712 chr1:2946727 NA 0.33 5.45 0.32 1.17e-7 Plateletcrit; CESC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.69 -0.33 3.38e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6580649 0.941 rs726354 chr12:48500334 G/A cg05342945 chr12:48394962 COL2A1 0.55 6.35 0.36 9.14e-10 Lung cancer; CESC cis rs9487051 0.837 rs2356817 chr6:109642675 G/A cg21918786 chr6:109611834 NA -0.37 -5.39 -0.31 1.54e-7 Reticulocyte fraction of red cells; CESC cis rs10129255 0.518 rs7143784 chr14:107143294 A/G cg23076370 chr14:107095027 NA -0.63 -9.65 -0.51 4.43e-19 Kawasaki disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16609818 chr17:41622807 ETV4 -0.39 -6.05 -0.35 4.8e-9 Gambling; CESC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.06e-7 Developmental language disorder (linguistic errors); CESC trans rs10241579 1.000 rs28391248 chr7:52771787 C/T cg18715243 chr8:37658755 GPR124 -0.48 -6.04 -0.35 5.21e-9 Inhibitory control; CESC cis rs6580649 0.941 rs11613485 chr12:48462455 T/C cg24011408 chr12:48396354 COL2A1 -0.41 -5.27 -0.31 2.86e-7 Lung cancer; CESC trans rs1945213 0.694 rs1384088 chr11:55848713 G/C cg03929089 chr4:120376271 NA -0.77 -7.3 -0.41 3.35e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs75477785 1.000 rs10779515 chr1:209987632 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.84 5.54 0.32 7.21e-8 Cleft lip with or without cleft palate; CESC cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg05283184 chr6:79620031 NA -0.44 -6.64 -0.38 1.74e-10 Intelligence (multi-trait analysis); CESC cis rs2050392 0.544 rs598672 chr10:30742388 C/T cg18806716 chr10:30721971 MAP3K8 -0.54 -8.2 -0.45 1.02e-14 Inflammatory bowel disease; CESC cis rs9649465 1.000 rs10215466 chr7:123326044 G/T cg04330084 chr7:123175371 IQUB -0.38 -5.22 -0.31 3.69e-7 Migraine; CESC cis rs2228479 0.702 rs12600047 chr16:89831630 G/A cg04013166 chr16:89971882 TCF25 0.77 6.51 0.37 3.84e-10 Skin colour saturation; CESC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg22535103 chr8:58192502 C8orf71 -0.92 -10.16 -0.53 1.04e-20 Developmental language disorder (linguistic errors); CESC cis rs2425143 0.730 rs6579259 chr20:34462550 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -6.93 -0.39 3.22e-11 Blood protein levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23939166 chr14:55032812 NA -0.49 -6.87 -0.39 4.5e-11 Gut microbiota (bacterial taxa); CESC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg13393036 chr8:95962371 TP53INP1 -0.48 -10.36 -0.54 2.51e-21 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01402448 chr6:136571605 FAM54A 0.52 6.16 0.35 2.67e-9 Gut microbiome composition (summer); CESC cis rs6570726 0.935 rs367643 chr6:145859602 A/C cg23711669 chr6:146136114 FBXO30 0.8 11.74 0.58 6.58e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs6598955 0.724 rs12732295 chr1:26602251 C/T cg04990556 chr1:26633338 UBXN11 -0.79 -11.42 -0.57 7.97e-25 Obesity-related traits; CESC cis rs9910055 0.615 rs189049 chr17:42197213 A/C cg09913183 chr17:42254507 C17orf65;ASB16 -0.69 -9.24 -0.49 8.36e-18 Total body bone mineral density; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg24141078 chr1:32671127 IQCC -0.42 -6.17 -0.35 2.57e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs8051149 0.688 rs12444670 chr16:87870312 C/T cg01829163 chr16:87871160 SLC7A5 -0.55 -6.91 -0.39 3.52e-11 Blood metabolite levels; CESC cis rs55883249 0.957 rs62119431 chr2:9750461 G/A cg23886495 chr2:9695866 ADAM17 0.64 5.76 0.33 2.35e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs6831352 0.819 rs1230158 chr4:99990186 T/C cg12011299 chr4:100065546 ADH4 0.65 8.15 0.45 1.49e-14 Alcohol dependence; CESC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg00149659 chr3:10157352 C3orf10 0.61 6.61 0.38 2.1e-10 Alzheimer's disease; CESC cis rs2549003 1.000 rs2549005 chr5:131827191 C/T cg00255919 chr5:131827918 IRF1 0.45 5.69 0.33 3.41e-8 Asthma (sex interaction); CESC trans rs10776614 0.799 rs56058334 chr10:49766777 A/G cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs2070997 0.548 rs11244145 chr9:133674088 A/G cg11464064 chr9:133710261 ABL1 0.63 7.29 0.41 3.66e-12 Response to amphetamines; CESC cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg11952622 chr19:58962976 ZNF324B 0.47 6.38 0.37 7.68e-10 Uric acid clearance; CESC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.19 -0.3 4.19e-7 Bipolar disorder; CESC cis rs11098499 0.863 rs7678400 chr4:120461957 G/A cg24375607 chr4:120327624 NA 0.44 5.35 0.31 1.89e-7 Corneal astigmatism; CESC cis rs4888262 0.508 rs6564153 chr16:74658723 A/C cg01733217 chr16:74700730 RFWD3 0.89 12.4 0.61 3.83e-28 Testicular germ cell tumor; CESC cis rs2072732 0.808 rs67758087 chr1:2937031 A/G cg03976712 chr1:2946727 NA 0.34 5.37 0.31 1.75e-7 Plateletcrit; CESC cis rs2072499 0.554 rs1052067 chr1:156206121 C/T cg25208724 chr1:156163844 SLC25A44 0.67 8.57 0.47 8.82e-16 Testicular germ cell tumor; CESC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.43 5.48 0.32 1.01e-7 Lymphocyte counts; CESC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg10351095 chr21:47802916 PCNT -0.45 -6.14 -0.35 2.97e-9 Testicular germ cell tumor; CESC cis rs2204008 0.811 rs8189445 chr12:38276295 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.7 0.51 3.2e-19 Bladder cancer; CESC cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg12927641 chr6:109611667 NA 0.42 6.47 0.37 4.6e-10 Reticulocyte fraction of red cells; CESC cis rs10097731 0.908 rs77317991 chr8:82032468 C/T cg25230327 chr8:82042993 NA -0.62 -7.14 -0.4 8.86e-12 Serum total protein level; CESC cis rs8020095 0.571 rs7157394 chr14:67562769 G/C cg19548862 chr14:67692701 FAM71D -0.48 -5.93 -0.34 9.58e-9 Depression (quantitative trait); CESC cis rs139156536 1 rs139156536 chr17:38164432 TTTTA/T cg17467752 chr17:38218738 THRA 0.55 7.48 0.42 1.1e-12 Lymphocyte percentage of white cells; CESC cis rs3845702 0.736 rs115569960 chr2:180848214 C/T cg01881094 chr2:180872142 CWC22 1.05 8.97 0.48 5.61e-17 Schizophrenia; CESC cis rs870825 0.616 rs57316663 chr4:185630011 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs7607369 0.648 rs7582193 chr2:219652532 T/C cg02176678 chr2:219576539 TTLL4 -0.49 -8.59 -0.47 7.42e-16 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs9300255 0.639 rs941306 chr12:123715113 C/T cg05973401 chr12:123451056 ABCB9 0.5 5.58 0.32 5.95e-8 Neutrophil percentage of white cells; CESC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg10295955 chr4:187884368 NA -1.0 -17.08 -0.72 1.33e-44 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.964 rs12943202 chr17:17994332 T/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.43 -5.68 -0.33 3.61e-8 Total body bone mineral density; CESC cis rs7914558 1.000 rs7920251 chr10:104950197 C/T cg15744005 chr10:104629667 AS3MT -0.32 -5.08 -0.3 7.12e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6733011 0.542 rs6542860 chr2:99679376 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -5.51 -0.32 8.66e-8 Bipolar disorder; CESC cis rs796364 0.664 rs4673660 chr2:200915395 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.63 6.33 0.36 1.03e-9 Schizophrenia; CESC cis rs6665290 0.904 rs3795449 chr1:227181838 T/G cg10327440 chr1:227177885 CDC42BPA -1.21 -33.12 -0.9 3.39e-96 Myeloid white cell count; CESC cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.31 -5.16 -0.3 4.96e-7 Hemoglobin concentration; CESC cis rs2014572 0.967 rs11084492 chr19:57756026 A/T cg12963866 chr19:57752005 ZNF805 -0.49 -6.49 -0.37 4.09e-10 Hyperactive-impulsive symptoms; CESC cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg13877915 chr19:58951672 ZNF132 0.4 5.93 0.34 9.18e-9 Uric acid clearance; CESC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.49 5.64 0.33 4.25e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2380220 0.872 rs7750757 chr6:95997118 A/G cg04719120 chr6:96025338 MANEA 0.56 5.45 0.32 1.16e-7 Behavioural disinhibition (generation interaction); CESC cis rs72634258 0.786 rs7523335 chr1:8180210 G/A cg00042356 chr1:8021962 PARK7 0.5 5.43 0.32 1.29e-7 Inflammatory bowel disease; CESC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg19163074 chr7:65112434 INTS4L2 -0.41 -5.11 -0.3 6.29e-7 Aortic root size; CESC cis rs847577 0.748 rs940430 chr7:97716540 A/G cg21770322 chr7:97807741 LMTK2 0.64 10.52 0.54 7.29e-22 Breast cancer; CESC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg25838465 chr1:92012736 NA -0.6 -8.78 -0.47 2.04e-16 Breast cancer; CESC cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg06636001 chr8:8085503 FLJ10661 0.51 6.39 0.37 7.48e-10 Mood instability; CESC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg01238044 chr22:24384105 GSTT1 -0.46 -5.83 -0.34 1.63e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2228479 0.867 rs62052187 chr16:89973071 G/A cg04013166 chr16:89971882 TCF25 0.71 7.01 0.4 1.94e-11 Skin colour saturation; CESC cis rs10504229 0.679 rs72649119 chr8:58040301 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -6.85 -0.39 5e-11 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg23758822 chr17:41437982 NA 1.0 14.96 0.68 4.16e-37 Menopause (age at onset); CESC cis rs10463316 0.894 rs6891252 chr5:150762807 G/T cg03212797 chr5:150827313 SLC36A1 -0.55 -7.15 -0.4 8.53e-12 Metabolite levels (Pyroglutamine); CESC cis rs9388451 0.657 rs4895799 chr6:126052729 C/T cg05901451 chr6:126070800 HEY2 -0.56 -8.07 -0.44 2.44e-14 Brugada syndrome; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05790002 chr16:82033681 SDR42E1 0.46 6.31 0.36 1.18e-9 Fibrinogen levels; CESC cis rs9611565 0.592 rs5751139 chr22:42099981 G/C cg17376030 chr22:41985996 PMM1 -0.78 -8.45 -0.46 1.98e-15 Vitiligo; CESC cis rs1023500 0.505 rs134885 chr22:42673811 C/G cg04733989 chr22:42467013 NAGA 0.61 9.21 0.49 1.01e-17 Schizophrenia; CESC cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg17294928 chr15:75287854 SCAMP5 0.71 7.78 0.43 1.65e-13 Blood trace element (Zn levels); CESC cis rs791888 0.965 rs791876 chr10:89406527 G/A cg13926569 chr10:89418898 PAPSS2 -0.4 -5.43 -0.32 1.3e-7 Magnesium levels; CESC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg24829409 chr8:58192753 C8orf71 -0.53 -6.91 -0.39 3.55e-11 Developmental language disorder (linguistic errors); CESC cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg26597838 chr10:835615 NA 0.68 6.33 0.36 1.04e-9 Eosinophil percentage of granulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27158084 chr6:149813350 NA -0.44 -6.16 -0.35 2.67e-9 Gut microbiota (bacterial taxa); CESC cis rs7208859 0.573 rs11656278 chr17:29075188 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9902453 0.765 rs2628185 chr17:28070107 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.76 -10.2 -0.53 8.08e-21 Coffee consumption (cups per day); CESC cis rs4891159 0.548 rs690414 chr18:74117840 T/C cg24786174 chr18:74118243 ZNF516 0.85 16.07 0.7 4.75e-41 Longevity; CESC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs62103177 0.810 rs62103197 chr18:77632923 G/A cg12964065 chr18:77638022 KCNG2 0.58 5.36 0.31 1.78e-7 Opioid sensitivity; CESC cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 3.05e-8 Mean platelet volume; CESC trans rs2727020 0.734 rs1164664 chr11:49295542 T/G cg15704280 chr7:45808275 SEPT13 0.78 10.35 0.54 2.56e-21 Coronary artery disease; CESC cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg24110177 chr3:50126178 RBM5 -0.52 -7.35 -0.41 2.41e-12 Intelligence (multi-trait analysis); CESC cis rs2014572 0.967 rs10418480 chr19:57755055 C/T cg12963866 chr19:57752005 ZNF805 -0.49 -6.55 -0.37 2.9e-10 Hyperactive-impulsive symptoms; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12448664 chr15:85143675 ZSCAN2 0.5 6.98 0.39 2.33e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7818688 0.697 rs76815619 chr8:95981330 G/A cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1843834 0.505 rs4674911 chr2:225345254 A/G cg12698349 chr2:225449008 CUL3 0.61 8.84 0.48 1.33e-16 IgE levels in asthmatics (D.p. specific); CESC cis rs3859192 0.599 rs2302777 chr17:38179492 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.63 9.55 0.51 9.21e-19 White blood cell count; CESC cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg09455208 chr3:40491958 NA 0.5 8.35 0.46 3.82e-15 Renal cell carcinoma; CESC cis rs9318086 0.673 rs7981928 chr13:24435180 T/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.42 5.72 0.33 2.85e-8 Myopia (pathological); CESC cis rs1620921 0.505 rs1344730 chr6:161204995 G/A cg01280913 chr6:161186852 NA -0.4 -6.08 -0.35 4.23e-9 Lipoprotein (a) - cholesterol levels; CESC cis rs6032067 0.704 rs62208374 chr20:43765628 C/T cg10761708 chr20:43804764 PI3 0.54 6.07 0.35 4.4e-9 Blood protein levels; CESC trans rs57221529 0.766 rs12519469 chr5:581772 A/G cg25482853 chr8:67687455 SGK3 0.95 9.39 0.5 2.96e-18 Lung disease severity in cystic fibrosis; CESC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg05872129 chr22:39784769 NA -0.82 -9.32 -0.5 4.71e-18 IgG glycosylation; CESC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg21285383 chr16:89894308 SPIRE2 0.32 5.85 0.34 1.48e-8 Vitiligo; CESC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg14393609 chr7:65229607 NA -0.48 -6.24 -0.36 1.75e-9 Cotinine glucuronidation; CESC cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg24110177 chr3:50126178 RBM5 -0.54 -7.34 -0.41 2.56e-12 Intelligence (multi-trait analysis); CESC trans rs35110281 0.686 rs162399 chr21:44950020 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 7.35 0.41 2.48e-12 Mean corpuscular volume; CESC cis rs9549260 0.755 rs4325426 chr13:41216437 C/A cg21288729 chr13:41239152 FOXO1 0.65 8.62 0.47 6.27e-16 Red blood cell count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21005948 chr18:46065258 KIAA0427 0.44 6.08 0.35 4.13e-9 Gut microbiota (bacterial taxa); CESC cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg03433033 chr1:76189801 ACADM 0.73 10.13 0.53 1.39e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10242455 0.571 rs56167514 chr7:99161347 A/G cg25640893 chr7:99214727 ZNF498 0.74 5.74 0.33 2.6e-8 Blood metabolite levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09359817 chr16:28503405 CLN3 -0.51 -7.36 -0.41 2.27e-12 Gambling; CESC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs11997175 0.574 rs4389890 chr8:33658018 C/T ch.8.33884649F chr8:33765107 NA 0.71 9.31 0.5 5.04e-18 Body mass index; CESC cis rs9640161 0.673 rs34489187 chr7:150044379 G/A cg17279839 chr7:150038598 RARRES2 0.51 6.03 0.35 5.62e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs9611565 0.592 rs9611613 chr22:41961831 T/C cg17376030 chr22:41985996 PMM1 0.52 5.81 0.34 1.8e-8 Vitiligo; CESC cis rs698833 0.518 rs2033951 chr2:44556298 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.1 0.3 6.62e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg02725872 chr8:58115012 NA -0.42 -5.88 -0.34 1.25e-8 Developmental language disorder (linguistic errors); CESC cis rs8141529 0.778 rs5762795 chr22:29182500 C/A cg02153584 chr22:29168773 CCDC117 0.67 9.68 0.51 3.72e-19 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17142723 chr17:41324085 NBR1 0.44 6.32 0.36 1.08e-9 Gut microbiome composition (summer); CESC cis rs950776 0.648 rs57945453 chr15:78862845 C/T cg06917634 chr15:78832804 PSMA4 0.59 7.38 0.41 2.08e-12 Sudden cardiac arrest; CESC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg02269571 chr22:50332266 NA 0.52 6.56 0.37 2.88e-10 Schizophrenia; CESC cis rs459571 0.959 rs461462 chr9:136911272 C/T cg13789015 chr9:136890014 NCRNA00094 0.52 7.53 0.42 7.86e-13 Platelet distribution width; CESC cis rs11608355 0.545 rs2302707 chr12:109893797 G/A cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs4803468 1.000 rs11880539 chr19:41918949 A/C cg08639244 chr19:41945921 ATP5SL 0.41 5.19 0.3 4.21e-7 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05262316 chr6:64345491 NA -0.43 -6.03 -0.35 5.4e-9 Gut microbiota (bacterial taxa); CESC cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg11366901 chr6:160182831 ACAT2 0.7 8.21 0.45 9.49e-15 Age-related macular degeneration (geographic atrophy); CESC cis rs17401966 0.931 rs746881 chr1:10346810 C/T cg15208524 chr1:10270712 KIF1B -0.45 -5.77 -0.33 2.26e-8 Hepatocellular carcinoma; CESC cis rs7044106 0.762 rs3904197 chr9:123480378 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.16 0.63 8.79e-31 Hip circumference adjusted for BMI; CESC cis rs763121 0.853 rs5757181 chr22:39013522 G/A cg06022373 chr22:39101656 GTPBP1 0.83 11.94 0.59 1.35e-26 Menopause (age at onset); CESC cis rs796364 0.760 rs11690371 chr2:200989616 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.76 -6.57 -0.37 2.71e-10 Schizophrenia; CESC cis rs3818285 0.655 rs2475277 chr10:111639730 C/T cg00817464 chr10:111662876 XPNPEP1 0.48 7.5 0.42 9.91e-13 Superior crus of antihelix expression; CESC trans rs1814175 0.781 rs11040681 chr11:49981654 G/T cg03929089 chr4:120376271 NA -0.93 -15.75 -0.7 6.66e-40 Height; CESC cis rs4969178 0.965 rs12451791 chr17:76397343 G/A cg20026190 chr17:76395443 PGS1 0.49 7.81 0.43 1.34e-13 HDL cholesterol levels; CESC cis rs17253792 0.822 rs76918910 chr14:56058762 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg26587870 chr6:27730563 NA -0.53 -5.08 -0.3 7.23e-7 Breast cancer; CESC cis rs6942407 0.649 rs6975202 chr7:86860382 C/A cg02420886 chr7:86849541 C7orf23 0.55 5.2 0.3 3.92e-7 Food allergy; CESC cis rs9815354 0.812 rs57209010 chr3:41854743 A/T cg03022575 chr3:42003672 ULK4 0.7 6.34 0.36 1.01e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs2066819 1.000 rs1802236 chr12:56679751 A/G cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg03188948 chr7:1209495 NA 0.59 5.96 0.34 7.81e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg21251018 chr6:28226885 NKAPL 0.34 5.15 0.3 5.08e-7 Depression; CESC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg04315214 chr1:2043799 PRKCZ 0.61 10.33 0.54 3e-21 Height; CESC cis rs4253772 0.591 rs6007732 chr22:46652303 A/T cg09491104 chr22:46646882 C22orf40 -0.58 -8.79 -0.48 1.88e-16 LDL cholesterol;Cholesterol, total; CESC cis rs2404602 0.692 rs66866130 chr15:77128574 T/C cg26408565 chr15:76604113 ETFA -0.37 -5.43 -0.32 1.26e-7 Blood metabolite levels; CESC cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg21770322 chr7:97807741 LMTK2 0.58 8.64 0.47 5.26e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg23034840 chr1:205782522 SLC41A1 0.67 8.05 0.44 2.78e-14 Menarche (age at onset); CESC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg13206674 chr6:150067644 NUP43 0.42 5.89 0.34 1.19e-8 Lung cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12121965 chr21:46293563 PTTG1IP 0.44 6.03 0.35 5.63e-9 Gut microbiota (bacterial taxa); CESC cis rs9611565 0.694 rs202616 chr22:41822221 C/G cg17376030 chr22:41985996 PMM1 -0.76 -8.01 -0.44 3.71e-14 Vitiligo; CESC cis rs17401966 0.894 rs12722830 chr1:10395134 A/G cg15208524 chr1:10270712 KIF1B 0.43 5.5 0.32 9.01e-8 Hepatocellular carcinoma; CESC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg06108461 chr20:60628389 TAF4 0.82 11.36 0.57 1.29e-24 Body mass index; CESC cis rs2832077 0.527 rs9980449 chr21:30224889 G/C cg08807101 chr21:30365312 RNF160 -0.66 -8.57 -0.47 8.73e-16 Cognitive test performance; CESC trans rs35110281 0.782 rs1454651 chr21:45012476 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 6.21 0.36 2.07e-9 Mean corpuscular volume; CESC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs9549260 0.592 rs9532588 chr13:41302913 G/A cg21288729 chr13:41239152 FOXO1 0.57 7.13 0.4 9.34e-12 Red blood cell count; CESC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg20307385 chr11:47447363 PSMC3 0.69 8.9 0.48 9.19e-17 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22424536 chr5:175792478 ARL10 -0.66 -8.06 -0.44 2.6e-14 Gut microbiome composition (summer); CESC cis rs66530629 0.874 rs6667299 chr1:25158500 T/C cg22509179 chr1:25234806 RUNX3 -0.44 -5.69 -0.33 3.32e-8 Plateletcrit; CESC cis rs1153858 0.943 rs7402632 chr15:45701913 A/T cg21132104 chr15:45694354 SPATA5L1 0.87 11.65 0.58 1.36e-25 Homoarginine levels; CESC cis rs1153858 1.000 rs7494956 chr15:45668565 T/C cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs7044106 0.708 rs10760113 chr9:123474050 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.01 0.35 5.97e-9 Hip circumference adjusted for BMI; CESC cis rs643506 0.874 rs645411 chr11:111694490 T/C cg17089665 chr11:111648010 NA -0.36 -5.18 -0.3 4.3e-7 Breast cancer; CESC trans rs1814175 0.645 rs11040703 chr11:50024961 C/T cg03929089 chr4:120376271 NA -0.91 -14.8 -0.67 1.58e-36 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24607948 chr9:100459097 XPA -0.42 -6.05 -0.35 4.92e-9 Gambling; CESC cis rs1483890 0.638 rs1564756 chr3:69402489 T/G cg22125112 chr3:69402811 FRMD4B -0.38 -5.05 -0.3 8.09e-7 Resting heart rate; CESC cis rs3768617 0.565 rs10752897 chr1:183071024 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.14 0.63 1.04e-30 Fuchs's corneal dystrophy; CESC cis rs9916302 0.752 rs11078895 chr17:37401051 A/G cg00129232 chr17:37814104 STARD3 -0.51 -5.34 -0.31 1.99e-7 Glomerular filtration rate (creatinine); CESC cis rs10791097 0.694 rs2155752 chr11:130755998 C/T cg09137382 chr11:130731461 NA 0.34 5.1 0.3 6.52e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6499255 1.000 rs7189424 chr16:69782746 G/A cg15192750 chr16:69999425 NA 0.44 5.43 0.32 1.27e-7 IgE levels; CESC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg19099843 chr7:12443191 VWDE -0.5 -5.26 -0.31 2.97e-7 Coronary artery disease; CESC cis rs2204008 0.749 rs10880692 chr12:38592918 C/G cg26384229 chr12:38710491 ALG10B -0.75 -11.36 -0.57 1.3e-24 Bladder cancer; CESC cis rs796364 0.806 rs74938253 chr2:201008386 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -6.43 -0.37 5.87e-10 Schizophrenia; CESC cis rs6500602 0.701 rs8053770 chr16:4539030 T/A cg08645402 chr16:4508243 NA 0.43 6.69 0.38 1.35e-10 Schizophrenia; CESC cis rs4803468 0.935 rs13346603 chr19:41945837 T/A cg14132834 chr19:41945861 ATP5SL 0.66 8.19 0.45 1.1e-14 Height; CESC cis rs9309473 0.583 rs6705203 chr2:73574600 T/C cg20560298 chr2:73613845 ALMS1 -0.45 -5.95 -0.34 8.58e-9 Metabolite levels; CESC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg11644478 chr21:40555479 PSMG1 -0.95 -14.2 -0.66 2.12e-34 Cognitive function; CESC cis rs7246865 0.768 rs8106184 chr19:17159779 A/C cg19418318 chr19:17219073 MYO9B 0.35 5.63 0.33 4.5e-8 Reticulocyte fraction of red cells; CESC cis rs637571 0.654 rs1058068 chr11:65667796 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.57 6.82 0.39 6.05e-11 Eosinophil percentage of white cells; CESC cis rs8062405 0.737 rs11861132 chr16:28871860 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg06529439 chr2:88991002 RPIA -0.48 -6.16 -0.35 2.64e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs367615 0.679 rs11241021 chr5:108812090 T/G cg17395555 chr5:108820864 NA 0.66 11.19 0.57 4.53e-24 Colorectal cancer (SNP x SNP interaction); CESC trans rs931812 1.000 rs4734495 chr8:101917817 C/A cg20993868 chr7:22813445 NA 0.48 6.58 0.37 2.54e-10 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs2573652 1.000 rs2573651 chr15:100514109 T/G cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.44 -0.32 1.21e-7 Height; CESC cis rs651907 0.557 rs34181125 chr3:101490278 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 6.85 0.39 5.18e-11 Colorectal cancer; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg16308174 chr11:70049109 FADD -0.41 -6.01 -0.35 6.05e-9 Vertical cup-disc ratio; CESC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg08632164 chr7:65971372 NA -0.32 -5.19 -0.3 4.25e-7 Aortic root size; CESC cis rs12541635 0.934 rs1353450 chr8:107035120 A/G cg10147462 chr8:107024639 NA -0.38 -5.36 -0.31 1.79e-7 Age of smoking initiation; CESC cis rs8020095 0.528 rs9671368 chr14:67263455 G/A cg19548862 chr14:67692701 FAM71D -0.49 -6.01 -0.35 6.17e-9 Depression (quantitative trait); CESC cis rs10911232 0.507 rs10752888 chr1:182993751 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 13.21 0.63 5.94e-31 Hypertriglyceridemia; CESC cis rs8062405 1.000 rs7187776 chr16:28857645 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -6.13 -0.35 3.24e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9611565 0.921 rs5751080 chr22:41736267 A/G cg06634786 chr22:41940651 POLR3H -0.44 -5.03 -0.3 9.13e-7 Vitiligo; CESC trans rs4596713 0.508 rs7862404 chr9:71779903 G/A cg16512924 chr15:28394682 HERC2 0.48 6.14 0.35 2.95e-9 Headache; CESC cis rs7818345 0.935 rs6983973 chr8:19287867 T/C cg11303988 chr8:19266685 CSGALNACT1 0.37 6.69 0.38 1.33e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs2880765 0.835 rs730372 chr15:86038193 G/T cg19183879 chr15:85880815 NA 0.26 5.32 0.31 2.21e-7 Coronary artery disease; CESC cis rs4253772 0.550 rs6008762 chr22:46736228 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.61 5.56 0.32 6.49e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg19592336 chr6:28129416 ZNF389 0.45 6.34 0.36 9.91e-10 Parkinson's disease; CESC cis rs10492096 0.947 rs11559082 chr12:6602367 C/T cg13857086 chr12:6580257 VAMP1 0.6 5.91 0.34 1.04e-8 Hip geometry; CESC cis rs68170813 0.641 rs75639044 chr7:107092631 A/C cg02696742 chr7:106810147 HBP1 -0.56 -5.19 -0.3 4.1e-7 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27304813 chr3:120068385 LRRC58 0.55 7.2 0.4 6.38e-12 Gut microbiota (bacterial taxa); CESC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg24562669 chr7:97807699 LMTK2 0.51 7.35 0.41 2.45e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.546 rs10007424 chr4:98885450 C/T cg17366294 chr4:99064904 C4orf37 0.5 6.35 0.36 9.43e-10 Colonoscopy-negative controls vs population controls; CESC trans rs7246657 0.943 rs2126977 chr19:37995747 C/G cg24637308 chr11:6592297 DNHD1 -0.51 -6.15 -0.35 2.85e-9 Coronary artery calcification; CESC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg09699651 chr6:150184138 LRP11 0.51 6.5 0.37 3.92e-10 Lung cancer; CESC cis rs17666538 0.535 rs4338080 chr8:615598 A/G cg07234876 chr8:600039 NA 0.81 5.83 0.34 1.62e-8 IgG glycosylation; CESC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg05863683 chr7:1912471 MAD1L1 -0.36 -5.23 -0.31 3.48e-7 Bipolar disorder and schizophrenia; CESC cis rs7605827 0.930 rs2111455 chr2:15549882 C/T cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.42e-9 Educational attainment (years of education); CESC cis rs2204008 0.837 rs7315255 chr12:37949279 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.76 0.38 8.75e-11 Bladder cancer; CESC cis rs826838 0.967 rs1684413 chr12:39128704 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg11644478 chr21:40555479 PSMG1 -0.55 -7.63 -0.42 4.34e-13 Menarche (age at onset); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg26035463 chr12:117627651 FBXO21 0.48 6.18 0.35 2.46e-9 Systemic lupus erythematosus; CESC cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg01579765 chr21:45077557 HSF2BP -0.55 -9.2 -0.49 1.12e-17 Mean corpuscular volume; CESC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg11764359 chr7:65958608 NA 0.78 10.12 0.53 1.44e-20 Aortic root size; CESC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg17372223 chr3:52568218 NT5DC2 -0.37 -5.26 -0.31 2.95e-7 Bipolar disorder; CESC cis rs7312774 0.618 rs7968263 chr12:107330844 C/A cg16260113 chr12:107380972 MTERFD3 0.79 6.83 0.39 5.68e-11 Severe influenza A (H1N1) infection; CESC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg18512352 chr11:47633146 NA 0.44 6.35 0.36 9.22e-10 Subjective well-being; CESC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg06481639 chr22:41940642 POLR3H -0.59 -5.91 -0.34 1.08e-8 Vitiligo; CESC cis rs4481887 0.646 rs28421649 chr1:248548122 G/C cg26353448 chr1:248524236 OR2T4 -0.39 -5.98 -0.34 7.17e-9 Common traits (Other); CESC cis rs9814567 1.000 rs6439484 chr3:134249899 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.08 -0.35 4.19e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg22823121 chr1:150693482 HORMAD1 0.45 6.31 0.36 1.17e-9 Melanoma; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg21932297 chr7:97910808 BRI3 0.5 6.56 0.37 2.79e-10 Breast cancer;Type 2 diabetes; CESC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg24531977 chr5:56204891 C5orf35 -0.89 -11.65 -0.58 1.36e-25 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25620125 chr11:61106775 DAK -0.59 -6.42 -0.37 6.16e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15739904 chr8:125313885 NA -0.56 -6.32 -0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs12618769 0.520 rs72821904 chr2:99084882 G/A cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs56399783 0.901 rs73049305 chr7:2778755 C/T cg19731401 chr7:2775893 GNA12 0.65 5.89 0.34 1.18e-8 Childhood ear infection; CESC cis rs6504663 0.596 rs7208018 chr17:48557863 C/T cg03168497 chr17:48586147 MYCBPAP -0.45 -5.32 -0.31 2.24e-7 Visceral fat; CESC cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg02487422 chr3:49467188 NICN1 0.44 5.61 0.33 4.99e-8 Parkinson's disease; CESC cis rs7949030 0.588 rs2509961 chr11:62310909 T/C cg11742103 chr11:62369870 EML3;MTA2 0.57 8.63 0.47 5.87e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs854765 0.583 rs4413022 chr17:17858280 G/C cg09796270 chr17:17721594 SREBF1 0.44 6.05 0.35 4.92e-9 Total body bone mineral density; CESC cis rs7617773 0.780 rs34523942 chr3:48342669 C/T cg11946769 chr3:48343235 NME6 0.83 11.2 0.57 4.23e-24 Coronary artery disease; CESC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.51 6.15 0.35 2.81e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4727027 0.933 rs28767030 chr7:148825918 T/G cg23583168 chr7:148888333 NA -0.74 -10.89 -0.56 4.6e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg16680214 chr1:154839983 KCNN3 -0.47 -7.44 -0.42 1.41e-12 Prostate cancer; CESC cis rs425277 0.958 rs262639 chr1:2107061 G/T cg24578937 chr1:2090814 PRKCZ 0.54 9.43 0.5 2.1e-18 Height; CESC cis rs3733585 0.673 rs4560411 chr4:9953361 A/G cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.39 6.29 0.36 1.29e-9 Personality dimensions; CESC cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg17427002 chr7:12443146 VWDE -0.52 -5.04 -0.3 8.67e-7 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15921587 chr2:73144353 EMX1 -0.44 -6.27 -0.36 1.47e-9 Fibrinogen levels; CESC cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg21573476 chr21:45109991 RRP1B -0.5 -6.89 -0.39 3.99e-11 Mean corpuscular volume; CESC cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.41 0.41 1.73e-12 Tonsillectomy; CESC cis rs6547741 1.000 rs13026621 chr2:27807624 G/A cg27432699 chr2:27873401 GPN1 0.49 6.85 0.39 5.03e-11 Oral cavity cancer; CESC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs1950626 0.623 rs3742401 chr14:101453344 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.67 8.97 0.48 5.38e-17 Pelvic organ prolapse (moderate/severe); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00894870 chr1:19578612 MRTO4;KIAA0090 -0.43 -6.15 -0.35 2.88e-9 Gambling; CESC cis rs10751667 0.666 rs10794354 chr11:954615 A/T cg01483505 chr11:975446 AP2A2 0.37 5.05 0.3 8.3e-7 Alzheimer's disease (late onset); CESC cis rs6751744 0.513 rs6738215 chr2:160453305 C/T cg08347373 chr2:160653686 CD302 -0.32 -5.3 -0.31 2.49e-7 Dysphagia; CESC cis rs7267979 1.000 rs2424713 chr20:25418482 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 15.87 0.7 2.52e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs11792861 0.816 rs2304779 chr9:111670513 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.54 -7.12 -0.4 1.01e-11 Menarche (age at onset); CESC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg00166722 chr3:10149974 C3orf24 0.46 5.9 0.34 1.13e-8 Alzheimer's disease; CESC cis rs6541297 0.887 rs4846906 chr1:230284257 C/A cg05784532 chr1:230284198 GALNT2 0.52 5.83 0.34 1.64e-8 Coronary artery disease; CESC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg07092213 chr7:1199455 ZFAND2A -0.51 -5.52 -0.32 8.03e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11645898 0.810 rs72787085 chr16:72182564 C/T cg14768367 chr16:72042858 DHODH -0.76 -6.49 -0.37 4.28e-10 Blood protein levels; CESC cis rs1577917 0.771 rs2758844 chr6:86330115 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -7.45 -0.42 1.36e-12 Response to antipsychotic treatment; CESC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg21984481 chr17:79567631 NPLOC4 -0.49 -8.04 -0.44 2.97e-14 Eye color traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11454606 chr11:67888949 CHKA -0.43 -6.09 -0.35 3.91e-9 Fibrinogen levels; CESC cis rs9905704 0.671 rs4337355 chr17:56950920 C/T cg12560992 chr17:57184187 TRIM37 0.62 7.85 0.43 1.03e-13 Testicular germ cell tumor; CESC cis rs12325245 0.536 rs8058781 chr16:58653838 G/A cg02549819 chr16:58548995 SETD6 0.94 6.09 0.35 4.04e-9 Schizophrenia; CESC cis rs2370759 0.891 rs77706860 chr10:32628537 C/T cg18270830 chr10:32634957 EPC1 0.66 5.63 0.33 4.62e-8 Sexual dysfunction (female); CESC cis rs959260 0.623 rs2164244 chr17:73325244 C/T cg20590849 chr17:73267439 MIF4GD -0.43 -5.35 -0.31 1.94e-7 Systemic lupus erythematosus; CESC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg19468946 chr17:37922297 IKZF3 0.4 5.17 0.3 4.69e-7 Glomerular filtration rate (creatinine); CESC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs748404 0.697 rs493444 chr15:43566470 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.5 7.8 0.43 1.45e-13 Lung cancer; CESC cis rs992157 0.710 rs56364928 chr2:219059058 G/A cg00012203 chr2:219082015 ARPC2 0.87 12.47 0.61 2.24e-28 Colorectal cancer; CESC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.2e-8 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17561891 chr7:86849173 C7orf23 0.61 6.58 0.37 2.45e-10 Gut microbiome composition (summer); CESC cis rs9908102 0.746 rs73296600 chr17:12903988 G/C cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs2243480 1.000 rs316307 chr7:65570171 C/T cg12463550 chr7:65579703 CRCP 0.74 5.74 0.33 2.59e-8 Diabetic kidney disease; CESC cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.11 0.3 6.22e-7 Hip circumference adjusted for BMI; CESC cis rs7267979 1.000 rs3761117 chr20:25388070 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -17.84 -0.74 2.71e-47 Liver enzyme levels (alkaline phosphatase); CESC cis rs10911232 0.507 rs10911230 chr1:183051118 A/C ch.1.3577855R chr1:183094577 LAMC1 0.85 13.7 0.64 1.21e-32 Hypertriglyceridemia; CESC cis rs7520050 0.902 rs4626927 chr1:46248645 C/T cg03146154 chr1:46216737 IPP -0.49 -6.36 -0.36 8.95e-10 Red blood cell count;Reticulocyte count; CESC trans rs60843830 0.964 rs17713879 chr2:254215 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 7.95 0.44 5.3e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs17764205 0.777 rs28729385 chr19:3258882 T/C cg02612712 chr19:3985498 EEF2 0.63 5.17 0.3 4.64e-7 Bipolar disorder and schizophrenia; CESC cis rs2952156 0.920 rs1476278 chr17:37836243 C/T cg00129232 chr17:37814104 STARD3 -0.78 -11.59 -0.58 2.06e-25 Asthma; CESC cis rs9640161 0.789 rs10952250 chr7:150025966 T/C cg13722127 chr7:150037890 RARRES2 0.34 5.29 0.31 2.6e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs5758659 0.904 rs134877 chr22:42662371 C/T cg05082376 chr22:42548792 NA -0.4 -5.93 -0.34 9.66e-9 Cognitive function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26495393 chr16:31473952 ARMC5 0.45 6.44 0.37 5.53e-10 Fibrinogen levels; CESC cis rs4889855 0.530 rs62068346 chr17:78608052 A/G cg16591659 chr17:78472290 NA -0.34 -5.49 -0.32 9.53e-8 Fractional excretion of uric acid; CESC cis rs67311347 1.000 rs977652 chr3:40479169 A/G cg09455208 chr3:40491958 NA 0.47 8.15 0.45 1.46e-14 Renal cell carcinoma; CESC cis rs763121 0.819 rs5757161 chr22:38990662 G/A cg21395723 chr22:39101663 GTPBP1 0.47 6.19 0.36 2.27e-9 Menopause (age at onset); CESC cis rs66573146 1.000 rs67067921 chr4:6984341 A/T cg00086871 chr4:6988644 TBC1D14 1.15 6.76 0.38 8.7e-11 Granulocyte percentage of myeloid white cells; CESC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg22535103 chr8:58192502 C8orf71 -0.75 -8.9 -0.48 8.89e-17 Developmental language disorder (linguistic errors); CESC cis rs67311347 1.000 rs2276871 chr3:40499273 C/T cg09455208 chr3:40491958 NA 0.5 8.49 0.46 1.48e-15 Renal cell carcinoma; CESC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.57 0.32 6.16e-8 Menopause (age at onset); CESC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg24209194 chr3:40518798 ZNF619 0.53 6.52 0.37 3.53e-10 Renal cell carcinoma; CESC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.94 10.26 0.53 5.16e-21 Platelet count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11914902 chr12:106751322 POLR3B 0.45 6.23 0.36 1.79e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs526821 0.595 rs4938937 chr11:55305507 T/A cg15704280 chr7:45808275 SEPT13 -0.52 -6.4 -0.37 7.03e-10 Pediatric bone mineral density (spine); CESC cis rs2730245 0.527 rs1188974 chr7:158665748 C/T cg24397884 chr7:158709396 WDR60 0.77 8.2 0.45 1.03e-14 Height; CESC cis rs7103648 1.000 rs11039225 chr11:47430599 G/A cg03711944 chr11:47377212 SPI1 -0.31 -5.04 -0.3 8.72e-7 Diastolic blood pressure;Systolic blood pressure; CESC trans rs67340775 0.834 rs13218875 chr6:27884012 C/T cg06606381 chr12:133084897 FBRSL1 -1.09 -8.62 -0.47 6.27e-16 Lung cancer in ever smokers; CESC cis rs3008870 1.000 rs12044278 chr1:67460977 T/C cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.19 -0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg22133161 chr19:49891603 CCDC155 0.47 5.3 0.31 2.47e-7 Multiple sclerosis; CESC cis rs6541297 0.699 rs1555290 chr1:230294989 A/C cg20703242 chr1:230279135 GALNT2 -0.54 -6.24 -0.36 1.72e-9 Coronary artery disease; CESC cis rs34779708 0.966 rs4934540 chr10:35474699 T/C cg03585969 chr10:35415529 CREM 0.74 9.81 0.52 1.39e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs7592578 0.771 rs1128723 chr2:191366707 A/G cg10560079 chr2:191398806 TMEM194B -0.68 -6.07 -0.35 4.3e-9 Diastolic blood pressure; CESC cis rs72772090 0.634 rs72773906 chr5:96092274 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -5.58 -0.32 5.79e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1976403 0.659 rs10799700 chr1:21820968 G/C cg21906605 chr1:21766650 NBPF3 0.4 5.29 0.31 2.6e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg22968622 chr17:43663579 NA -0.76 -10.12 -0.53 1.47e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10876993 0.928 rs2640631 chr12:58067532 A/T cg18357645 chr12:58087776 OS9 0.61 10.24 0.53 6.11e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs17428076 0.556 rs12692976 chr2:172684403 G/T cg13550731 chr2:172543902 DYNC1I2 -0.56 -7.43 -0.42 1.46e-12 Myopia; CESC cis rs8141529 0.764 rs5752807 chr22:29223169 A/G cg15103426 chr22:29168792 CCDC117 0.68 9.65 0.51 4.52e-19 Lymphocyte counts; CESC cis rs71277158 0.688 rs77248289 chr3:169905625 C/T cg04067573 chr3:169899625 PHC3 0.7 6.72 0.38 1.09e-10 Prostate cancer; CESC cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 10.92 0.56 3.64e-23 Personality dimensions; CESC cis rs9611519 0.761 rs35445172 chr22:41660301 G/A cg17376030 chr22:41985996 PMM1 0.43 5.04 0.3 8.52e-7 Neuroticism; CESC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.17 0.3 4.63e-7 Menopause (age at onset); CESC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg06456125 chr7:65229604 NA -0.4 -5.15 -0.3 4.99e-7 Aortic root size; CESC cis rs4835473 0.736 rs11724009 chr4:144905444 C/A cg25736465 chr4:144833511 NA 0.41 6.25 0.36 1.65e-9 Immature fraction of reticulocytes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01102847 chr14:50053293 RPS29 -0.47 -6.24 -0.36 1.72e-9 Fibrinogen levels; CESC trans rs208520 0.706 rs851601 chr6:66893853 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -11.17 -0.57 5.31e-24 Exhaled nitric oxide output; CESC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg23985595 chr17:80112537 CCDC57 0.42 6.56 0.37 2.87e-10 Life satisfaction; CESC cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg05313129 chr8:58192883 C8orf71 -0.57 -6.47 -0.37 4.59e-10 Developmental language disorder (linguistic errors); CESC cis rs7762018 1.000 rs4716378 chr6:170086568 G/C cg05834625 chr6:170176447 C6orf70 0.62 7.41 0.41 1.7e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6460942 0.659 rs6969309 chr7:12515847 T/C cg20607287 chr7:12443886 VWDE -0.7 -7.58 -0.42 5.83e-13 Coronary artery disease; CESC cis rs10791097 0.609 rs3751039 chr11:130773076 A/G cg09137382 chr11:130731461 NA -0.35 -5.27 -0.31 2.89e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs5758659 0.714 rs6002626 chr22:42517989 C/G cg19513890 chr22:42538836 CYP2D7P1 0.38 5.48 0.32 9.98e-8 Cognitive function; CESC cis rs793571 0.544 rs1427282 chr15:58914326 C/T cg05156742 chr15:59063176 FAM63B 0.8 11.73 0.58 7.43e-26 Schizophrenia; CESC cis rs6570726 0.875 rs416243 chr6:145868081 A/T cg23711669 chr6:146136114 FBXO30 0.8 11.78 0.59 4.84e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg05340658 chr4:99064831 C4orf37 0.84 13.04 0.63 2.35e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9858542 0.953 rs67216675 chr3:49493151 G/T cg07274523 chr3:49395745 GPX1 0.66 8.15 0.45 1.41e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg06022373 chr22:39101656 GTPBP1 0.89 14.32 0.66 7.5e-35 Menopause (age at onset); CESC cis rs17376456 0.825 rs28534784 chr5:93063332 C/A cg25358565 chr5:93447407 FAM172A 1.09 10.86 0.55 5.92e-23 Diabetic retinopathy; CESC cis rs9325144 0.555 rs7301258 chr12:38706942 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.39 0.41 1.93e-12 Morning vs. evening chronotype; CESC cis rs459571 0.839 rs2519831 chr9:136886257 T/A cg13789015 chr9:136890014 NCRNA00094 0.57 8.15 0.45 1.45e-14 Platelet distribution width; CESC cis rs7267979 1.000 rs2027004 chr20:25350618 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -15.92 -0.7 1.72e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs41271473 0.539 rs763519 chr1:228892855 A/G cg00850481 chr1:228891306 NA 0.45 6.03 0.35 5.46e-9 Chronic lymphocytic leukemia; CESC trans rs7615952 0.534 rs1503072 chr3:125754691 C/T cg07211511 chr3:129823064 LOC729375 -0.59 -6.52 -0.37 3.53e-10 Blood pressure (smoking interaction); CESC cis rs921968 0.541 rs933995 chr2:219650718 G/A cg02176678 chr2:219576539 TTLL4 -0.44 -7.81 -0.43 1.3e-13 Mean corpuscular hemoglobin concentration; CESC cis rs1878931 0.501 rs17136359 chr16:3420814 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.76 -10.12 -0.53 1.42e-20 Body mass index (adult); CESC cis rs2985684 0.901 rs2354448 chr14:50098296 G/A cg02151108 chr14:50098012 C14orf104 -0.42 -5.48 -0.32 9.97e-8 Carotid intima media thickness; CESC cis rs1215050 0.740 rs783945 chr4:99014394 G/A cg17366294 chr4:99064904 C4orf37 -0.4 -5.26 -0.31 3.01e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs6032067 0.777 rs979641 chr20:43786336 C/T cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs12472274 0.646 rs34465035 chr2:239114093 C/A cg17459225 chr2:239074497 NA 0.51 6.01 0.35 6.11e-9 Phospholipid levels (plasma); CESC cis rs3008870 0.958 rs12143044 chr1:67460054 A/T cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.19 -0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs7223966 0.515 rs2727315 chr17:61961458 C/T cg11494091 chr17:61959527 GH2 0.42 5.73 0.33 2.66e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2354432 0.556 rs4424557 chr1:146871119 A/G cg25205988 chr1:146714368 CHD1L 1.02 8.91 0.48 8.56e-17 Mitochondrial DNA levels; CESC cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg19163074 chr7:65112434 INTS4L2 0.52 5.4 0.31 1.5e-7 Aortic root size; CESC cis rs11864453 0.927 rs1035560 chr16:72032730 T/C cg01557791 chr16:72042693 DHODH -0.67 -8.93 -0.48 7.45e-17 Fibrinogen levels; CESC cis rs8018808 0.935 rs11627385 chr14:77936343 T/C cg20045696 chr14:77926864 AHSA1 0.43 5.9 0.34 1.13e-8 Myeloid white cell count; CESC cis rs2228479 0.557 rs62054639 chr16:89821489 C/T cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs9399135 0.967 rs2297338 chr6:135375762 G/A cg24558204 chr6:135376177 HBS1L 0.52 7.19 0.4 6.61e-12 Red blood cell count; CESC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg00166722 chr3:10149974 C3orf24 -0.49 -5.64 -0.33 4.43e-8 Alzheimer's disease; CESC cis rs17125944 0.686 rs76673112 chr14:53366692 T/C cg00686598 chr14:53173677 PSMC6 0.95 7.15 0.4 8.21e-12 Alzheimer's disease (late onset); CESC cis rs1030877 0.515 rs2576742 chr2:105898822 A/T cg02079111 chr2:105885981 TGFBRAP1 0.49 6.53 0.37 3.31e-10 Obesity-related traits; CESC cis rs3126085 0.935 rs11204937 chr1:152193851 C/T cg26876637 chr1:152193138 HRNR 0.46 5.35 0.31 1.89e-7 Atopic dermatitis; CESC trans rs7726839 0.540 rs3749615 chr5:601485 C/T cg25482853 chr8:67687455 SGK3 1.01 10.04 0.52 2.65e-20 Obesity-related traits; CESC cis rs2235642 0.653 rs7197288 chr16:1654753 C/A cg03771183 chr16:1608904 IFT140 0.38 5.54 0.32 7.18e-8 Coronary artery disease; CESC cis rs7618501 1.000 rs9872864 chr3:49792023 A/G cg24308560 chr3:49941425 MST1R 0.52 7.15 0.4 8.43e-12 Intelligence (multi-trait analysis); CESC cis rs8044868 0.530 rs2241411 chr16:72144493 T/C cg16558253 chr16:72132732 DHX38 -0.39 -6.08 -0.35 4.07e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg05343316 chr1:45956843 TESK2 0.48 6.17 0.35 2.49e-9 Red blood cell count;Reticulocyte count; CESC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg25072359 chr17:41440525 NA 0.43 5.84 0.34 1.5e-8 Menopause (age at onset); CESC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg00149659 chr3:10157352 C3orf10 0.74 9.14 0.49 1.63e-17 Alzheimer's disease; CESC cis rs1775715 0.870 rs11008702 chr10:32244818 T/G cg18675610 chr10:32216311 ARHGAP12 0.33 5.18 0.3 4.44e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs963731 0.649 rs1377860 chr2:39290425 C/G cg04010122 chr2:39346883 SOS1 0.69 5.69 0.33 3.31e-8 Corticobasal degeneration; CESC cis rs4704187 0.712 rs7701262 chr5:74365986 C/T cg03227963 chr5:74354835 NA 0.31 5.68 0.33 3.62e-8 Response to amphetamines; CESC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg07952391 chr2:88470173 THNSL2 -0.54 -8.15 -0.45 1.47e-14 Response to metformin (IC50); CESC cis rs4566357 0.615 rs3769645 chr2:227913717 A/G cg05526886 chr2:227700861 RHBDD1 -0.47 -6.23 -0.36 1.87e-9 Coronary artery disease; CESC cis rs9486715 0.867 rs9386500 chr6:96889845 A/C cg18709589 chr6:96969512 KIAA0776 0.45 6.29 0.36 1.31e-9 Headache; CESC cis rs6580649 0.941 rs7971668 chr12:48469696 T/C cg05342945 chr12:48394962 COL2A1 0.5 5.74 0.33 2.59e-8 Lung cancer; CESC cis rs2576037 0.796 rs2576039 chr18:44582148 C/T cg19077165 chr18:44547161 KATNAL2 0.51 7.13 0.4 9.38e-12 Personality dimensions; CESC cis rs6788895 0.661 rs77431731 chr3:150489911 T/G cg09723797 chr3:150481914 SIAH2 0.69 5.11 0.3 6.18e-7 Breast cancer; CESC cis rs7937682 0.921 rs1944119 chr11:111436387 A/G cg22437258 chr11:111473054 SIK2 -0.73 -8.38 -0.46 3.14e-15 Primary sclerosing cholangitis; CESC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg07167872 chr1:205819463 PM20D1 0.78 12.16 0.6 2.43e-27 Menarche (age at onset); CESC cis rs2769264 0.505 rs4246526 chr1:151403916 G/T cg18801370 chr1:151430492 POGZ 0.56 6.88 0.39 4.42e-11 Blood trace element (Cu levels); CESC cis rs9815354 0.812 rs73828254 chr3:41810180 T/A cg03022575 chr3:42003672 ULK4 0.68 6.06 0.35 4.7e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7197653 0.748 rs8060690 chr16:68340085 G/T cg26727032 chr16:67993705 SLC12A4 -0.53 -5.12 -0.3 5.91e-7 Magnesium levels; CESC cis rs7116495 1.000 rs10736786 chr11:71763274 C/T cg26138937 chr11:71823887 C11orf51 -0.81 -6.47 -0.37 4.6e-10 Severe influenza A (H1N1) infection; CESC cis rs11792861 0.926 rs11787878 chr9:111866749 C/T cg13535736 chr9:111863775 C9orf5 -0.5 -6.65 -0.38 1.68e-10 Menarche (age at onset); CESC cis rs787274 0.543 rs62576453 chr9:115629921 C/T cg13803584 chr9:115635662 SNX30 -0.63 -5.9 -0.34 1.1e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6963495 0.818 rs55922564 chr7:105155890 G/A cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs5753618 0.504 rs9609296 chr22:31891784 T/G cg13145458 chr22:31556086 RNF185 -0.52 -5.85 -0.34 1.44e-8 Colorectal cancer; CESC cis rs9911578 1.000 rs302859 chr17:56693132 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC cis rs34172651 0.917 rs1075987 chr16:24794957 G/A cg06028605 chr16:24865363 SLC5A11 0.35 5.46 0.32 1.11e-7 Intelligence (multi-trait analysis); CESC cis rs2180341 0.680 rs9388554 chr6:127576234 C/G cg24812749 chr6:127587940 RNF146 0.84 11.79 0.59 4.6e-26 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20617676 chr7:123389167 WASL -0.48 -6.37 -0.36 8.45e-10 Fibrinogen levels; CESC cis rs295140 0.605 rs296818 chr2:201176944 C/T cg23649088 chr2:200775458 C2orf69 0.46 6.24 0.36 1.73e-9 QT interval; CESC cis rs6662572 0.737 rs7525281 chr1:46267923 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.11 -0.3 6.16e-7 Blood protein levels; CESC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.03 -0.3 8.96e-7 Breast cancer; CESC cis rs6061231 1.000 rs6061231 chr20:60956917 C/A cg24112000 chr20:60950667 NA -0.57 -7.81 -0.43 1.33e-13 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06074332 chr11:111473729 SIK2 0.57 6.44 0.37 5.49e-10 Gut microbiome composition (summer); CESC cis rs3824867 0.676 rs7104366 chr11:47462115 G/A cg20307385 chr11:47447363 PSMC3 0.5 6.06 0.35 4.73e-9 Mean corpuscular hemoglobin; CESC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 9.59 0.51 6.99e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg25767906 chr1:53392781 SCP2 -0.44 -5.5 -0.32 9.08e-8 Monocyte count; CESC trans rs208520 0.754 rs851594 chr6:66876695 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.51 -0.61 1.58e-28 Exhaled nitric oxide output; CESC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg08968635 chr6:28129556 ZNF389 0.42 5.75 0.33 2.45e-8 Depression; CESC cis rs8044868 0.530 rs12918956 chr16:72224335 A/G cg01557791 chr16:72042693 DHODH 0.42 5.77 0.33 2.23e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.67 0.33 3.7e-8 Bipolar disorder; CESC cis rs1577917 0.771 rs12199873 chr6:86294947 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -7.8 -0.43 1.46e-13 Response to antipsychotic treatment; CESC cis rs847577 0.569 rs12674083 chr7:97696334 C/T cg21770322 chr7:97807741 LMTK2 0.82 14.51 0.67 1.69e-35 Breast cancer; CESC cis rs9905704 0.846 rs7212271 chr17:56863918 C/T cg12560992 chr17:57184187 TRIM37 0.62 7.8 0.43 1.45e-13 Testicular germ cell tumor; CESC cis rs6546537 0.562 rs7565783 chr2:69750113 C/T cg10773587 chr2:69614142 GFPT1 -0.53 -6.66 -0.38 1.54e-10 Serum thyroid-stimulating hormone levels; CESC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg24675658 chr1:53192096 ZYG11B -0.5 -6.2 -0.36 2.16e-9 Monocyte count; CESC trans rs6445797 0.788 rs11714608 chr3:56662215 T/C cg15444621 chr13:113611794 NA 0.33 6.04 0.35 5.18e-9 Gastritis; CESC cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg22875332 chr1:76189707 ACADM 0.6 5.66 0.33 3.89e-8 Blood metabolite levels;Acylcarnitine levels; CESC trans rs7937682 0.924 rs7938360 chr11:111539875 A/G cg18187862 chr3:45730750 SACM1L 0.5 6.36 0.36 8.88e-10 Primary sclerosing cholangitis; CESC cis rs11229555 0.645 rs10896785 chr11:58233395 G/A cg15696309 chr11:58395628 NA -0.45 -5.26 -0.31 2.93e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs7296418 0.630 rs28419092 chr12:123812629 G/C cg00376283 chr12:123451042 ABCB9 0.56 7.64 0.42 3.92e-13 Platelet count; CESC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg27170947 chr2:26402098 FAM59B 0.79 8.45 0.46 1.91e-15 Gut microbiome composition (summer); CESC cis rs6499255 1.000 rs11075733 chr16:69773435 G/T cg15192750 chr16:69999425 NA 0.51 6.16 0.35 2.75e-9 IgE levels; CESC cis rs28489187 0.730 rs233130 chr1:85795112 T/C cg16011679 chr1:85725395 C1orf52 0.47 5.6 0.33 5.46e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg22105103 chr4:187893119 NA -0.44 -5.89 -0.34 1.14e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7937682 0.575 rs7114617 chr11:111768173 A/T cg22437258 chr11:111473054 SIK2 -0.48 -5.3 -0.31 2.44e-7 Primary sclerosing cholangitis; CESC cis rs17067123 1.000 rs10024135 chr4:180039244 A/G cg26610307 chr4:180072759 NA -0.51 -5.35 -0.31 1.91e-7 Response to hepatitis C treatment; CESC cis rs67311347 1.000 rs9874006 chr3:40471596 G/A cg01475735 chr3:40494733 NA -0.4 -5.04 -0.3 8.45e-7 Renal cell carcinoma; CESC cis rs858239 0.601 rs7805206 chr7:23160210 C/T cg23682824 chr7:23144976 KLHL7 0.47 6.3 0.36 1.2e-9 Cerebrospinal fluid biomarker levels; CESC cis rs4253772 0.591 rs9615934 chr22:46682310 C/G cg09491104 chr22:46646882 C22orf40 -0.53 -5.88 -0.34 1.25e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg03452623 chr4:187889614 NA -0.93 -18.87 -0.76 6.53e-51 Lobe attachment (rater-scored or self-reported); CESC trans rs36206051 1.000 rs7043056 chr9:90202347 A/G cg05779585 chr8:1246817 NA -0.63 -6.16 -0.35 2.65e-9 Night sleep phenotypes; CESC cis rs6088580 0.601 rs6059827 chr20:33016358 C/T cg06115741 chr20:33292138 TP53INP2 0.48 6.21 0.36 2.09e-9 Glomerular filtration rate (creatinine); CESC cis rs9847710 0.733 rs2581790 chr3:53101780 A/G cg07507251 chr3:52567010 NT5DC2 -0.33 -5.08 -0.3 7.2e-7 Ulcerative colitis; CESC cis rs7223966 1.000 rs11658329 chr17:61763031 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.45 5.59 0.32 5.68e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC cis rs7818688 0.858 rs7826196 chr8:96029002 A/G cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9486719 1.000 rs4839837 chr6:96908706 G/A cg06623918 chr6:96969491 KIAA0776 0.88 10.38 0.54 2.16e-21 Migraine;Coronary artery disease; CESC cis rs2228479 0.702 rs62052710 chr16:89854893 C/T cg04013166 chr16:89971882 TCF25 0.78 6.67 0.38 1.44e-10 Skin colour saturation; CESC cis rs910316 0.692 rs7156586 chr14:75506230 A/T cg16144293 chr14:75469539 EIF2B2 -0.51 -6.62 -0.38 2.03e-10 Height; CESC cis rs9916302 0.706 rs4795358 chr17:37573065 A/C cg07936489 chr17:37558343 FBXL20 -0.91 -9.93 -0.52 5.62e-20 Glomerular filtration rate (creatinine); CESC cis rs9287719 0.967 rs6744599 chr2:10747013 C/G cg00105475 chr2:10696890 NA -0.38 -5.53 -0.32 7.55e-8 Prostate cancer; CESC cis rs2370759 0.898 rs113412621 chr10:32579306 C/T cg18270830 chr10:32634957 EPC1 0.73 7.22 0.41 5.35e-12 Sexual dysfunction (female); CESC cis rs7116495 0.881 rs1939243 chr11:71742735 A/G cg10381502 chr11:71823885 C11orf51 0.64 5.09 0.3 6.87e-7 Severe influenza A (H1N1) infection; CESC cis rs2180341 1.000 rs13218061 chr6:127653758 G/A cg24812749 chr6:127587940 RNF146 1.07 15.4 0.69 1.16e-38 Breast cancer; CESC cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg11941060 chr3:133502564 NA 0.44 5.88 0.34 1.26e-8 Iron status biomarkers; CESC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg25517755 chr10:38738941 LOC399744 -0.44 -5.72 -0.33 2.85e-8 Extrinsic epigenetic age acceleration; CESC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 9.59 0.51 6.65e-19 Platelet count; CESC cis rs2072732 0.821 rs7339938 chr1:2963493 G/C cg15211996 chr1:2936768 ACTRT2 0.31 5.46 0.32 1.11e-7 Plateletcrit; CESC cis rs10804591 0.848 rs6782700 chr3:129309147 G/A cg21885638 chr3:129306552 PLXND1 -0.34 -5.22 -0.31 3.63e-7 Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Hip circumference adjusted for BMI;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7267979 0.789 rs6076347 chr20:25398790 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.68 -11.32 -0.57 1.75e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs12477438 0.520 rs11123762 chr2:99727789 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.61 0.69 2.15e-39 Chronic sinus infection; CESC cis rs2204008 0.720 rs11181343 chr12:38323616 G/T cg13010199 chr12:38710504 ALG10B 0.45 5.63 0.33 4.49e-8 Bladder cancer; CESC cis rs7937682 0.924 rs7924683 chr11:111555796 C/A cg22437258 chr11:111473054 SIK2 0.68 9.01 0.48 4.15e-17 Primary sclerosing cholangitis; CESC cis rs2108225 0.967 rs6466189 chr7:107448516 C/T cg18560240 chr7:107437656 SLC26A3 -0.38 -5.03 -0.3 8.96e-7 Ulcerative colitis; CESC cis rs11785400 0.890 rs13279182 chr8:143720544 A/G cg24634471 chr8:143751801 JRK 0.4 5.12 0.3 5.91e-7 Schizophrenia; CESC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg07308232 chr7:1071921 C7orf50 -0.6 -8.38 -0.46 3.2e-15 Longevity;Endometriosis; CESC cis rs703842 1.000 rs3825079 chr12:58203354 C/T cg18357645 chr12:58087776 OS9 -0.42 -5.9 -0.34 1.12e-8 Multiple sclerosis; CESC cis rs662064 0.962 rs668805 chr1:10544547 A/G cg20482658 chr1:10539492 PEX14 0.4 8.42 0.46 2.46e-15 Asthma; CESC trans rs6570726 0.791 rs1935612 chr6:145906090 T/A cg03826317 chr10:25465503 LOC100128811;GPR158 0.31 6.15 0.35 2.8e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg05343316 chr1:45956843 TESK2 -0.52 -6.59 -0.38 2.33e-10 High light scatter reticulocyte count; CESC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg14393609 chr7:65229607 NA -0.46 -6.14 -0.35 3.03e-9 Aortic root size; CESC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg00149659 chr3:10157352 C3orf10 0.71 8.4 0.46 2.72e-15 Alzheimer's disease; CESC cis rs2708240 1.000 rs2708240 chr7:147577537 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.32 -5.29 -0.31 2.51e-7 QT interval (drug interaction); CESC cis rs4268898 0.552 rs11125455 chr2:24374557 C/G cg06627628 chr2:24431161 ITSN2 0.6 8.23 0.45 8.28e-15 Asthma; CESC cis rs1559088 0.744 rs12972060 chr19:33537096 C/T cg27124370 chr19:33622961 WDR88 -0.44 -5.5 -0.32 8.93e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1843834 0.611 rs1058360 chr2:225449242 A/T cg12698349 chr2:225449008 CUL3 0.61 8.56 0.47 9.55e-16 IgE levels in asthmatics (D.p. specific); CESC cis rs1153858 0.943 rs28605551 chr15:45641720 C/T cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs9790314 0.875 rs163327 chr3:161062724 A/G cg03342759 chr3:160939853 NMD3 -0.47 -6.42 -0.37 6.15e-10 Morning vs. evening chronotype; CESC cis rs72792276 1.000 rs72794361 chr5:127435188 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.64 5.12 0.3 5.82e-7 Red cell distribution width; CESC cis rs4853012 0.887 rs2280642 chr2:74358252 T/A cg19729930 chr2:74357872 NA 0.91 12.88 0.62 8.64e-30 Gestational age at birth (maternal effect); CESC cis rs9399137 0.507 rs6904897 chr6:135382980 T/G cg24558204 chr6:135376177 HBS1L 0.69 9.56 0.51 8.81e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs938554 0.784 rs1071988 chr4:9974638 A/G cg00071950 chr4:10020882 SLC2A9 -0.47 -5.68 -0.33 3.54e-8 Blood metabolite levels; CESC cis rs6963495 0.818 rs114865717 chr7:105158526 C/T cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03509671 chr3:101497876 FAM55C 0.57 6.31 0.36 1.19e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07956897 chr2:20647393 RHOB 0.4 6.08 0.35 4.17e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6688613 0.694 rs2075946 chr1:166818566 A/G ch.1.3259774R chr1:166827647 TADA1 0.6 6.1 0.35 3.71e-9 Refractive astigmatism; CESC cis rs9457247 1.000 rs409356 chr6:167405226 T/A cg25258033 chr6:167368657 RNASET2 0.39 5.88 0.34 1.26e-8 Crohn's disease; CESC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg08888203 chr3:10149979 C3orf24 0.48 6.09 0.35 3.99e-9 Alzheimer's disease; CESC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg11494091 chr17:61959527 GH2 0.77 14.79 0.67 1.75e-36 Prudent dietary pattern; CESC cis rs9457247 0.663 rs10946205 chr6:167451311 A/G cg25258033 chr6:167368657 RNASET2 0.37 5.26 0.31 2.95e-7 Crohn's disease; CESC cis rs2228479 0.850 rs17226966 chr16:89825338 A/G cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.34e-11 Skin colour saturation; CESC cis rs7927771 0.507 rs7119517 chr11:47675316 T/C cg20307385 chr11:47447363 PSMC3 0.62 8.8 0.48 1.77e-16 Subjective well-being; CESC cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg00825309 chr19:58991885 ZNF446 -0.55 -7.86 -0.43 9.42e-14 Uric acid clearance; CESC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg12463550 chr7:65579703 CRCP 0.51 6.41 0.37 6.58e-10 Aortic root size; CESC cis rs72634258 0.891 rs35731977 chr1:8014568 G/A cg00042356 chr1:8021962 PARK7 0.84 7.07 0.4 1.4e-11 Inflammatory bowel disease; CESC cis rs8114671 0.586 rs6087634 chr20:33413809 G/A cg24642439 chr20:33292090 TP53INP2 0.44 5.21 0.31 3.72e-7 Height; CESC cis rs2797160 1.000 rs1418951 chr6:125996185 A/G cg05901451 chr6:126070800 HEY2 -0.45 -6.66 -0.38 1.55e-10 Endometrial cancer; CESC cis rs7267979 0.899 rs6115213 chr20:25550372 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.75 13.02 0.62 2.64e-30 Liver enzyme levels (alkaline phosphatase); CESC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg03388025 chr16:89894329 SPIRE2 0.41 7.74 0.43 2.12e-13 Vitiligo; CESC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg25072359 chr17:41440525 NA 0.49 6.53 0.37 3.36e-10 Menopause (age at onset); CESC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg21724239 chr8:58056113 NA 0.6 5.45 0.32 1.17e-7 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.3 -0.36 1.24e-9 Bipolar disorder; CESC trans rs8073060 0.586 rs8077826 chr17:34001139 G/A cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg25430849 chr7:99699006 MCM7;AP4M1 0.44 6.16 0.35 2.68e-9 Post-traumatic stress disorder; CESC cis rs4237845 0.537 rs9645819 chr12:58270063 T/C cg00677455 chr12:58241039 CTDSP2 0.77 10.25 0.53 5.63e-21 Intelligence (multi-trait analysis); CESC cis rs3812762 0.871 rs10734637 chr11:8788225 A/C cg03980550 chr11:8754370 ST5 0.37 5.43 0.32 1.28e-7 Hypospadias; CESC cis rs2304069 0.954 rs4705408 chr5:149412545 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.9 -11.69 -0.58 1.02e-25 HIV-1 control; CESC cis rs9818758 0.607 rs34580506 chr3:49113713 C/A cg00383909 chr3:49044727 WDR6 0.92 6.59 0.38 2.35e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18766056 chr1:39457186 AKIRIN1 -0.53 -6.72 -0.38 1.09e-10 Ulcerative colitis; CESC cis rs7772486 0.790 rs2265474 chr6:146182092 G/A cg23711669 chr6:146136114 FBXO30 1.03 15.9 0.7 2.01e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs7077164 0.960 rs1227777 chr10:71581131 A/G cg07630274 chr10:71583235 COL13A1 0.41 8.29 0.45 5.83e-15 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg17724175 chr1:150552817 MCL1 0.4 6.21 0.36 2.04e-9 Melanoma; CESC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg04166393 chr7:2884313 GNA12 -0.56 -7.17 -0.4 7.57e-12 Height; CESC cis rs7208859 0.673 rs9912122 chr17:29140716 C/A cg14008862 chr17:28927542 LRRC37B2 0.57 5.43 0.32 1.3e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg03433033 chr1:76189801 ACADM 0.69 8.34 0.46 4.16e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2276314 0.857 rs62101376 chr18:33582955 T/C cg19628046 chr18:33552617 C18orf21 0.47 5.04 0.3 8.63e-7 Endometriosis;Drug-induced torsades de pointes; CESC cis rs854765 0.693 rs8079321 chr17:17760789 C/T cg16928487 chr17:17741425 SREBF1 -0.54 -9.63 -0.51 5.09e-19 Total body bone mineral density; CESC trans rs11098499 0.954 rs3890049 chr4:120326283 T/A cg25214090 chr10:38739885 LOC399744 0.71 9.8 0.52 1.46e-19 Corneal astigmatism; CESC cis rs12791968 1.000 rs10838397 chr11:45009133 A/G cg11846598 chr11:44996168 LOC221122 0.59 7.98 0.44 4.53e-14 Inhibitory control; CESC cis rs7223966 1.000 rs6504170 chr17:61709168 C/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.49 -5.88 -0.34 1.21e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7762018 0.770 rs3823466 chr6:170189926 C/T cg13891659 chr6:170190454 C6orf122;C6orf208 0.61 6.14 0.35 2.97e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg00033643 chr7:134001901 SLC35B4 0.41 5.25 0.31 3.2e-7 Mean platelet volume; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.49 0.37 4.32e-10 Hemoglobin concentration; CESC cis rs6598955 0.671 rs12086573 chr1:26574330 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC cis rs77106637 1.000 rs76793820 chr11:72619860 G/A cg03713592 chr11:72463424 ARAP1 1.14 10.34 0.54 2.87e-21 Type 2 diabetes; CESC cis rs17253792 0.731 rs79483151 chr14:56048851 C/T cg01858014 chr14:56050164 KTN1 -0.99 -7.44 -0.42 1.43e-12 Putamen volume; CESC cis rs1348850 0.567 rs880898 chr2:178532470 C/T cg23306229 chr2:178417860 TTC30B 0.54 7.16 0.4 8.11e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9399135 0.660 rs4646868 chr6:135271946 A/G cg24558204 chr6:135376177 HBS1L 0.6 8.27 0.45 6.5e-15 Red blood cell count; CESC cis rs7833790 0.929 rs28464834 chr8:82797356 A/T cg07697082 chr8:82753677 SNX16 -0.38 -5.39 -0.31 1.54e-7 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27140083 chr15:75230280 COX5A 0.55 6.01 0.35 6.13e-9 Gut microbiome composition (summer); CESC cis rs10911232 0.507 rs10911222 chr1:183047363 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 13.6 0.64 2.66e-32 Hypertriglyceridemia; CESC cis rs9911578 1.000 rs9915935 chr17:56843048 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.29 0.31 2.6e-7 Intelligence (multi-trait analysis); CESC cis rs2066819 0.901 rs773665 chr12:56717466 C/T cg26734620 chr12:56694298 CS -0.92 -9.33 -0.5 4.31e-18 Psoriasis vulgaris; CESC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg21784768 chr11:537496 LRRC56 -0.57 -5.36 -0.31 1.85e-7 Body mass index; CESC cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg09035930 chr12:129282057 SLC15A4 0.68 9.02 0.48 4.03e-17 Systemic lupus erythematosus; CESC cis rs5769765 0.955 rs8138687 chr22:50291869 A/G cg02269571 chr22:50332266 NA -0.45 -6.05 -0.35 4.98e-9 Schizophrenia; CESC cis rs116095464 0.558 rs60251075 chr5:245292 T/C cg10591111 chr5:226296 SDHA -0.52 -6.38 -0.36 7.94e-10 Breast cancer; CESC trans rs3942852 0.806 rs4752893 chr11:48118604 C/T cg03929089 chr4:120376271 NA -0.56 -6.38 -0.36 7.84e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg21138405 chr5:131827807 IRF1 -0.63 -11.3 -0.57 1.97e-24 Asthma (sex interaction); CESC cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg15352829 chr14:105391018 PLD4 -0.59 -10.4 -0.54 1.75e-21 Rheumatoid arthritis; CESC cis rs1642645 0.831 rs768613 chr1:42485263 T/C cg16685388 chr1:42384056 HIVEP3 0.38 5.68 0.33 3.57e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg00166722 chr3:10149974 C3orf24 0.45 5.84 0.34 1.54e-8 Alzheimer's disease; CESC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg18252515 chr7:66147081 NA 0.39 5.18 0.3 4.4e-7 Aortic root size; CESC trans rs7618501 0.699 rs1317154 chr3:49910084 T/C cg21659725 chr3:3221576 CRBN 0.59 8.24 0.45 8.11e-15 Intelligence (multi-trait analysis); CESC cis rs4654899 1.000 rs7525438 chr1:21458217 G/A cg05370193 chr1:21551575 ECE1 0.41 6.2 0.36 2.2e-9 Superior frontal gyrus grey matter volume; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg09755579 chr2:61645972 SNORA70B;USP34 0.4 6.24 0.36 1.74e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2070488 0.736 rs2070988 chr3:38437835 C/T cg24069376 chr3:38537580 EXOG 0.37 6.22 0.36 1.89e-9 Electrocardiographic conduction measures; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27224195 chr8:11324244 FAM167A -0.45 -6.06 -0.35 4.77e-9 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24385632 chr11:16838615 PLEKHA7 0.54 7.25 0.41 4.65e-12 Fibrinogen levels; CESC cis rs67478160 0.654 rs4906365 chr14:104229230 G/C cg01849466 chr14:104193079 ZFYVE21 -0.48 -6.5 -0.37 3.95e-10 Schizophrenia; CESC cis rs2832191 0.671 rs68101501 chr21:30513229 G/T cg24692254 chr21:30365293 RNF160 -0.6 -7.63 -0.42 4.31e-13 Dental caries; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg25748441 chr2:202122587 CASP8 -0.49 -6.37 -0.36 8.4e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg00166722 chr3:10149974 C3orf24 0.49 5.98 0.34 7.37e-9 Alzheimer's disease; CESC cis rs7188697 0.922 rs37041 chr16:58579886 T/C cg21335942 chr16:58549945 SETD6 0.46 5.4 0.31 1.47e-7 QT interval; CESC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg02569458 chr12:86230093 RASSF9 0.41 5.76 0.33 2.32e-8 Major depressive disorder; CESC cis rs1448094 0.802 rs56391398 chr12:86424114 C/T cg02569458 chr12:86230093 RASSF9 0.39 5.77 0.33 2.23e-8 Major depressive disorder; CESC cis rs7666738 0.819 rs13120307 chr4:99036100 A/C cg18180107 chr4:99064573 C4orf37 0.43 5.4 0.31 1.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs7555523 0.887 rs4657471 chr1:165686873 T/C cg24409356 chr1:165738333 TMCO1 0.89 8.09 0.45 2.14e-14 Intraocular pressure;Glaucoma (high intraocular pressure); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01744729 chr13:113474194 ATP11A -0.59 -6.63 -0.38 1.92e-10 Gut microbiome composition (summer); CESC cis rs9487051 0.714 rs7744284 chr6:109616218 C/T cg01475377 chr6:109611718 NA -0.43 -6.8 -0.39 7.03e-11 Reticulocyte fraction of red cells; CESC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg15595755 chr5:1867978 NA 0.5 8.13 0.45 1.7e-14 Cardiovascular disease risk factors; CESC cis rs1707322 0.964 rs6675259 chr1:46502295 G/A cg06784218 chr1:46089804 CCDC17 -0.37 -5.97 -0.34 7.75e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs10905099 0.708 rs34463850 chr10:7094084 C/T cg05230642 chr15:25439252 SNORD115-14 -0.73 -6.17 -0.35 2.6e-9 Orofacial clefts; CESC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg22143856 chr6:28129313 ZNF389 0.42 5.25 0.31 3.16e-7 Parkinson's disease; CESC cis rs4588572 0.643 rs11744479 chr5:77729220 T/G cg11547950 chr5:77652471 NA -0.45 -5.6 -0.33 5.32e-8 Triglycerides; CESC cis rs5995756 0.712 rs9611205 chr22:40010521 G/A cg03390717 chr22:39966585 CACNA1I -0.31 -5.2 -0.3 3.92e-7 Autism spectrum disorder or schizophrenia; CESC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg00074818 chr8:8560427 CLDN23 0.34 5.15 0.3 5.12e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07021777 chr4:88312416 HSD17B11 0.54 6.28 0.36 1.41e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs969694 chr6:146394655 A/G cg05347473 chr6:146136440 FBXO30 0.51 7.04 0.4 1.66e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2315504 0.509 rs3760335 chr17:39026061 T/A cg05063374 chr17:38953512 KRT28 -0.45 -6.34 -0.36 9.66e-10 Height; CESC trans rs9929218 0.520 rs1078621 chr16:68778996 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.85 13.51 0.64 5.58e-32 Colorectal cancer; CESC cis rs561341 1.000 rs530209 chr17:30315287 A/G cg12193833 chr17:30244370 NA -0.7 -6.49 -0.37 4.19e-10 Hip circumference adjusted for BMI; CESC trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21659725 chr3:3221576 CRBN 0.82 13.21 0.63 5.87e-31 Intelligence (multi-trait analysis); CESC cis rs694739 0.628 rs617051 chr11:64133638 C/A cg02228329 chr11:64053129 BAD;GPR137 0.61 7.58 0.42 5.67e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs2933343 0.649 rs1683786 chr3:128626952 T/C cg11901034 chr3:128598214 ACAD9 -0.34 -5.04 -0.3 8.49e-7 IgG glycosylation; CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg04025307 chr7:1156635 C7orf50 0.55 9.27 0.49 6.93e-18 Longevity;Endometriosis; CESC cis rs561341 1.000 rs497479 chr17:30328605 C/T cg00745463 chr17:30367425 LRRC37B -0.82 -7.72 -0.43 2.42e-13 Hip circumference adjusted for BMI; CESC cis rs7923609 0.934 rs7923544 chr10:65182256 T/G cg01631684 chr10:65280961 REEP3 -0.44 -5.49 -0.32 9.57e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23692589 chr11:67256716 AIP -0.54 -6.59 -0.38 2.41e-10 Gut microbiome composition (summer); CESC cis rs3126085 0.597 rs12047544 chr1:152169922 C/T cg03465714 chr1:152285911 FLG -0.45 -5.53 -0.32 7.5e-8 Atopic dermatitis; CESC cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg17366294 chr4:99064904 C4orf37 0.56 7.78 0.43 1.6e-13 Colonoscopy-negative controls vs population controls; CESC cis rs4970966 0.951 rs6665912 chr1:150544093 T/C cg13175981 chr1:150552382 MCL1 0.54 5.86 0.34 1.39e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs4835473 0.897 rs62337587 chr4:144646992 C/A cg25736465 chr4:144833511 NA -0.44 -6.48 -0.37 4.41e-10 Immature fraction of reticulocytes; CESC cis rs6032067 0.925 rs62208424 chr20:43813341 G/A cg11264863 chr20:43835661 SEMG1 0.49 5.32 0.31 2.21e-7 Blood protein levels; CESC cis rs826838 0.967 rs4768330 chr12:39129399 T/C cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg08859206 chr1:53392774 SCP2 0.64 9.35 0.5 3.74e-18 Monocyte count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19979643 chr10:6018610 IL15RA 0.47 6.38 0.36 7.94e-10 Gut microbiota (bacterial taxa); CESC cis rs4664308 0.618 rs17830904 chr2:160891688 C/T cg03641300 chr2:160917029 PLA2R1 0.59 8.57 0.47 8.47e-16 Idiopathic membranous nephropathy; CESC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.41 6.86 0.39 4.85e-11 Personality dimensions; CESC cis rs3540 0.574 rs2601205 chr15:90961813 A/G cg10434728 chr15:90938212 IQGAP1 0.42 7.54 0.42 7.73e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs4689388 0.581 rs1801212 chr4:6302519 C/T cg25554036 chr4:6271136 WFS1 0.48 6.26 0.36 1.54e-9 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4718428 0.607 rs66954441 chr7:66369209 T/C cg18252515 chr7:66147081 NA -0.45 -5.09 -0.3 6.84e-7 Corneal structure; CESC cis rs7666738 0.830 rs7689495 chr4:98920152 T/C cg17366294 chr4:99064904 C4orf37 0.57 7.89 0.44 8.07e-14 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg05863683 chr7:1912471 MAD1L1 -0.45 -6.67 -0.38 1.48e-10 Bipolar disorder and schizophrenia; CESC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg13393036 chr8:95962371 TP53INP1 -0.55 -12.25 -0.6 1.25e-27 Type 2 diabetes; CESC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg05564831 chr3:52568323 NT5DC2 0.46 7.0 0.39 2.13e-11 Bipolar disorder; CESC cis rs4919694 1.000 rs12261040 chr10:104665397 T/C cg04362960 chr10:104952993 NT5C2 0.74 6.43 0.37 5.8e-10 Arsenic metabolism; CESC cis rs9584850 0.874 rs4584 chr13:99101869 G/C cg22223119 chr13:99095684 FARP1 -0.37 -5.28 -0.31 2.67e-7 Neuroticism; CESC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 13.23 0.63 5.11e-31 Platelet count; CESC cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg23018236 chr17:30244563 NA -0.55 -5.36 -0.31 1.81e-7 Hip circumference adjusted for BMI; CESC cis rs17376456 1.000 rs56046246 chr5:93531545 T/G cg21475434 chr5:93447410 FAM172A 0.9 7.81 0.43 1.38e-13 Diabetic retinopathy; CESC cis rs67478160 0.643 rs8005225 chr14:104300151 C/T cg08213375 chr14:104286397 PPP1R13B -0.53 -10.49 -0.54 9.03e-22 Schizophrenia; CESC cis rs6088590 1.000 rs6119516 chr20:33328024 C/T cg06115741 chr20:33292138 TP53INP2 0.57 7.12 0.4 9.93e-12 Coronary artery disease; CESC cis rs7134594 0.677 rs2075440 chr12:109859100 C/T cg19025524 chr12:109796872 NA 0.38 5.5 0.32 9.12e-8 HDL cholesterol; CESC cis rs9302635 0.513 rs35460163 chr16:72177060 C/T cg01557791 chr16:72042693 DHODH -0.63 -7.02 -0.4 1.83e-11 Blood protein levels; CESC cis rs763014 0.898 rs35666389 chr16:629458 A/G cg07256732 chr16:621771 PIGQ -0.3 -5.11 -0.3 6.07e-7 Height; CESC cis rs11583043 0.958 rs12730160 chr1:101438791 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 5.5 0.32 8.95e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg23758822 chr17:41437982 NA 1.03 14.75 0.67 2.37e-36 Menopause (age at onset); CESC cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg18180107 chr4:99064573 C4orf37 0.42 5.36 0.31 1.79e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7312933 0.558 rs1796388 chr12:42785987 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.51 -6.85 -0.39 5.05e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6088580 0.668 rs1205340 chr20:32923871 G/A cg08999081 chr20:33150536 PIGU -0.64 -11.04 -0.56 1.46e-23 Glomerular filtration rate (creatinine); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26270411 chr20:43514327 YWHAB -0.45 -6.37 -0.36 8.36e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11030122 0.702 rs2898947 chr11:3977572 G/A cg18678763 chr11:4115507 RRM1 -0.49 -6.52 -0.37 3.64e-10 Mean platelet volume;Platelet distribution width; CESC cis rs10899021 0.704 rs11236177 chr11:74339067 T/C cg25880958 chr11:74394337 NA -0.74 -7.86 -0.43 9.76e-14 Response to metformin (IC50); CESC cis rs2108622 0.727 rs62106158 chr19:15980492 T/G cg13772218 chr19:15982569 NA 0.3 5.87 0.34 1.27e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs2075371 0.674 rs11771785 chr7:134013249 A/G cg20476274 chr7:133979776 SLC35B4 -0.58 -7.6 -0.42 5.14e-13 Mean platelet volume; CESC cis rs7605378 1.000 rs2689766 chr2:200697539 A/T cg23649088 chr2:200775458 C2orf69 0.5 6.61 0.38 2.13e-10 Osteoporosis; CESC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg06074448 chr4:187884817 NA 0.38 5.37 0.31 1.72e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg24675658 chr1:53192096 ZYG11B -0.52 -6.56 -0.37 2.88e-10 Monocyte count; CESC cis rs637571 0.522 rs538954 chr11:65756808 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 6.46 0.37 4.93e-10 Eosinophil percentage of white cells; CESC cis rs1580019 0.587 rs10951338 chr7:32560089 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.73 0.38 1.05e-10 Cognitive ability; CESC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg04944784 chr2:26401820 FAM59B -0.92 -10.69 -0.55 2.14e-22 Gut microbiome composition (summer); CESC cis rs3762637 0.882 rs56074178 chr3:122180011 C/G cg24169773 chr3:122142474 KPNA1 -0.54 -6.33 -0.36 1.04e-9 LDL cholesterol levels; CESC cis rs116095464 0.558 rs6881920 chr5:222411 T/C cg22496380 chr5:211416 CCDC127 -0.72 -8.57 -0.47 8.59e-16 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03317280 chr1:228675123 RNF187 -0.5 -6.17 -0.35 2.55e-9 Ulcerative colitis; CESC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.63 -0.33 4.6e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs2795502 1.000 rs2795497 chr10:43339475 C/A cg27426351 chr10:43362370 NA -0.45 -5.5 -0.32 8.91e-8 Blood protein levels; CESC cis rs5769765 1.000 rs768618 chr22:50286827 G/A cg02269571 chr22:50332266 NA -0.46 -6.26 -0.36 1.53e-9 Schizophrenia; CESC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg08392591 chr16:89556376 ANKRD11 0.56 7.63 0.42 4.29e-13 Multiple myeloma (IgH translocation); CESC cis rs2346177 0.554 rs13002880 chr2:46708129 C/G cg02822958 chr2:46747628 ATP6V1E2 0.45 5.59 0.32 5.7e-8 HDL cholesterol; CESC cis rs854765 0.964 rs72827413 chr17:17988299 C/T cg04398451 chr17:18023971 MYO15A 0.67 9.39 0.5 2.84e-18 Total body bone mineral density; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg14311088 chr22:40573762 TNRC6B 0.47 6.32 0.36 1.09e-9 Neuroticism; CESC cis rs9911578 1.000 rs7207693 chr17:57016525 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.11 0.3 6.07e-7 Intelligence (multi-trait analysis); CESC cis rs921968 0.565 rs7595901 chr2:219606931 A/G cg02176678 chr2:219576539 TTLL4 -0.46 -8.15 -0.45 1.46e-14 Mean corpuscular hemoglobin concentration; CESC cis rs3020736 0.500 rs28791586 chr22:42500483 A/G cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg18252515 chr7:66147081 NA -0.46 -6.24 -0.36 1.71e-9 Aortic root size; CESC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg22467129 chr15:76604101 ETFA -0.37 -5.66 -0.33 4.01e-8 Blood metabolite levels; CESC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg03517284 chr6:25882590 NA -0.65 -9.09 -0.49 2.38e-17 Intelligence (multi-trait analysis); CESC cis rs6963495 0.585 rs1728653 chr7:105191335 A/G cg02135003 chr7:105160482 PUS7 -0.38 -5.59 -0.32 5.63e-8 Bipolar disorder (body mass index interaction); CESC trans rs1814175 0.817 rs4405313 chr11:50013636 G/A cg15704280 chr7:45808275 SEPT13 -1.05 -21.18 -0.79 6.15e-59 Height; CESC cis rs72792276 1.000 rs72794379 chr5:127464965 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.66 5.26 0.31 3.04e-7 Red cell distribution width; CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg23978390 chr7:1156363 C7orf50 0.59 8.2 0.45 1.04e-14 Longevity;Endometriosis; CESC cis rs9486719 0.895 rs4486019 chr6:96883814 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs7264396 0.635 rs6088971 chr20:34535373 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.07 -0.56 1.16e-23 Total cholesterol levels; CESC cis rs1707322 0.682 rs10890334 chr1:46100378 A/T cg06784218 chr1:46089804 CCDC17 0.4 6.99 0.39 2.23e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg18538332 chr22:24372958 LOC391322 -0.72 -10.45 -0.54 1.26e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3796619 1.000 rs4974638 chr4:1099201 G/A cg27284194 chr4:1044797 NA 0.37 5.49 0.32 9.59e-8 Recombination rate (males); CESC cis rs7824557 0.527 rs11785394 chr8:11238029 C/T cg21775007 chr8:11205619 TDH -0.5 -6.93 -0.39 3.13e-11 Retinal vascular caliber; CESC cis rs11785693 0.862 rs1156861 chr8:4984434 G/C cg26367366 chr8:4980734 NA 0.92 8.51 0.46 1.29e-15 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs1018836 0.923 rs6986088 chr8:91538474 A/C cg16814680 chr8:91681699 NA -0.72 -11.04 -0.56 1.4e-23 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9291683 0.527 rs11727087 chr4:10096020 A/G cg11266682 chr4:10021025 SLC2A9 0.55 10.48 0.54 9.67e-22 Bone mineral density; CESC cis rs7267979 1.000 rs34645895 chr20:25368373 A/G cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.88e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs367943 0.712 rs13157609 chr5:112683583 G/A cg12552261 chr5:112820674 MCC 0.41 5.3 0.31 2.49e-7 Type 2 diabetes; CESC cis rs684232 0.602 rs2543775 chr17:557123 G/A cg15660573 chr17:549704 VPS53 -0.8 -11.75 -0.59 6.18e-26 Prostate cancer; CESC cis rs11640533 0.901 rs2908790 chr16:53412161 T/C cg27158636 chr16:53407423 NA 0.38 5.14 0.3 5.39e-7 Intelligence (multi-trait analysis); CESC cis rs6952808 0.756 rs13234214 chr7:1878860 C/T cg13880726 chr7:1868755 MAD1L1 0.54 7.3 0.41 3.46e-12 Bipolar disorder and schizophrenia; CESC cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.73 9.49 0.5 1.44e-18 Multiple sclerosis; CESC cis rs7267979 1.000 rs2474777 chr20:25272633 A/G cg08601574 chr20:25228251 PYGB 0.39 5.9 0.34 1.13e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7236492 0.577 rs7236190 chr18:77198217 T/C cg15644404 chr18:77186268 NFATC1 -0.46 -5.33 -0.31 2.06e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs7662987 0.517 rs2851265 chr4:100029684 A/G cg12011299 chr4:100065546 ADH4 0.58 6.33 0.36 1.04e-9 Smoking initiation; CESC cis rs9486719 1.000 rs12210146 chr6:96903962 A/G cg06623918 chr6:96969491 KIAA0776 0.82 8.24 0.45 7.78e-15 Migraine;Coronary artery disease; CESC cis rs6088580 0.634 rs6059856 chr20:33057954 G/C cg06115741 chr20:33292138 TP53INP2 0.46 5.97 0.34 7.6e-9 Glomerular filtration rate (creatinine); CESC cis rs7072216 0.763 rs942804 chr10:100168499 C/A cg26618903 chr10:100175079 PYROXD2 -0.36 -5.47 -0.32 1.06e-7 Metabolite levels; CESC cis rs9733 0.744 rs2039590 chr1:150813315 G/A cg18016565 chr1:150552671 MCL1 -0.35 -5.67 -0.33 3.76e-8 Tonsillectomy; CESC cis rs910316 1.000 rs175425 chr14:75626131 T/C cg08847533 chr14:75593920 NEK9 -0.97 -17.65 -0.74 1.22e-46 Height; CESC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg08888203 chr3:10149979 C3orf24 0.54 6.78 0.38 7.97e-11 Alzheimer's disease; CESC trans rs4906172 0.773 rs10135238 chr14:102518870 C/T cg17920195 chr4:129149383 NA -0.31 -6.01 -0.35 5.97e-9 Menopause (age at onset); CESC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg17724175 chr1:150552817 MCL1 0.45 7.24 0.41 4.96e-12 Tonsillectomy; CESC cis rs5758511 0.680 rs56111723 chr22:42664883 T/A cg00645731 chr22:42541494 CYP2D7P1 0.57 8.59 0.47 7.36e-16 Birth weight; CESC cis rs909341 0.710 rs3848669 chr20:62300811 G/T cg03999872 chr20:62272968 STMN3 0.53 5.3 0.31 2.5e-7 Atopic dermatitis; CESC cis rs16858210 0.648 rs79478990 chr3:183587094 C/T cg03417191 chr3:183542750 MAP6D1 -0.46 -5.89 -0.34 1.17e-8 Menopause (age at onset); CESC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg27170947 chr2:26402098 FAM59B -0.72 -8.31 -0.45 5.18e-15 Gut microbiome composition (summer); CESC cis rs61931739 0.500 rs11053260 chr12:34530215 T/G cg06521331 chr12:34319734 NA -0.37 -5.15 -0.3 5.19e-7 Morning vs. evening chronotype; CESC cis rs826838 0.904 rs11612004 chr12:39204282 G/A cg13010199 chr12:38710504 ALG10B 0.58 8.05 0.44 2.77e-14 Heart rate; CESC cis rs887829 0.588 rs7556676 chr2:234658250 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.5 -6.48 -0.37 4.57e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg14773178 chr5:1868261 NA 0.33 5.88 0.34 1.22e-8 Cardiovascular disease risk factors; CESC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg18337363 chr3:52569053 NT5DC2 0.29 5.03 0.3 8.89e-7 Bipolar disorder; CESC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg15445000 chr17:37608096 MED1 0.41 6.87 0.39 4.66e-11 Glomerular filtration rate (creatinine); CESC cis rs9926296 0.712 rs2437957 chr16:89715648 G/A cg01097406 chr16:89675127 NA 0.38 5.33 0.31 2.14e-7 Vitiligo; CESC cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg25019033 chr10:957182 NA -0.56 -6.18 -0.35 2.42e-9 Eosinophil percentage of granulocytes; CESC cis rs193541 0.632 rs154503 chr5:122204499 G/A cg19412675 chr5:122181750 SNX24 0.46 5.49 0.32 9.54e-8 Glucose homeostasis traits; CESC cis rs853679 0.882 rs9380069 chr6:28203300 A/G cg23281280 chr6:28129359 ZNF389 0.55 5.8 0.34 1.85e-8 Depression; CESC cis rs9488822 0.636 rs7745074 chr6:116347432 G/A cg15226275 chr6:116381976 FRK 0.24 6.2 0.36 2.17e-9 Cholesterol, total;LDL cholesterol; CESC cis rs6089584 0.893 rs6089305 chr20:60571817 T/C cg24733560 chr20:60626293 TAF4 0.38 5.45 0.32 1.15e-7 Body mass index; CESC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg23283495 chr1:209979779 IRF6 -0.37 -5.68 -0.33 3.45e-8 Orofacial clefts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00969680 chr1:113466087 AFARP1;SLC16A1 -0.64 -7.09 -0.4 1.2e-11 Gut microbiome composition (summer); CESC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg12648201 chr2:27665141 KRTCAP3 -0.36 -6.64 -0.38 1.76e-10 Total body bone mineral density; CESC cis rs2274273 0.840 rs7159144 chr14:55821324 G/A cg04306507 chr14:55594613 LGALS3 0.32 6.31 0.36 1.19e-9 Protein biomarker; CESC cis rs4253772 0.530 rs9615958 chr22:46751122 A/G cg00784671 chr22:46762841 CELSR1 -0.6 -6.28 -0.36 1.36e-9 LDL cholesterol;Cholesterol, total; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09349940 chr16:22218118 EEF2K -0.46 -6.08 -0.35 4.16e-9 Asthma; CESC cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg10523679 chr1:76189770 ACADM -0.66 -6.71 -0.38 1.15e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1008375 1.000 rs10939746 chr4:17684951 A/G cg02297831 chr4:17616191 MED28 -0.41 -5.28 -0.31 2.67e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17129466 chr19:1848747 REXO1 -0.65 -7.64 -0.42 3.99e-13 Gut microbiome composition (summer); CESC cis rs17490626 0.512 rs12241097 chr10:71216678 T/G cg12610070 chr10:71211762 TSPAN15 -0.3 -6.33 -0.36 1.07e-9 Thrombosis; CESC trans rs7615952 0.599 rs12496921 chr3:125701948 C/G cg07211511 chr3:129823064 LOC729375 -0.55 -6.3 -0.36 1.2e-9 Blood pressure (smoking interaction); CESC cis rs7116495 1.000 rs677279 chr11:71770469 G/A cg10381502 chr11:71823885 C11orf51 -0.67 -5.66 -0.33 3.92e-8 Severe influenza A (H1N1) infection; CESC cis rs4319547 0.915 rs7314638 chr12:122983460 A/G cg05707623 chr12:122985044 ZCCHC8 -0.66 -7.7 -0.43 2.64e-13 Body mass index; CESC cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg04450456 chr4:17643702 FAM184B 0.36 5.05 0.3 8.3e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.57 6.96 0.39 2.69e-11 Height; CESC cis rs3008870 1.000 rs6673462 chr1:67461857 A/C cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.19 -0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg23161317 chr6:28129485 ZNF389 0.39 5.48 0.32 1.01e-7 Cardiac Troponin-T levels; CESC cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC trans rs9399401 0.961 rs6909857 chr6:142701158 A/G cg15730116 chr12:76953768 OSBPL8 -0.42 -6.08 -0.35 4.23e-9 Chronic obstructive pulmonary disease; CESC cis rs9487051 0.646 rs13203365 chr6:109614810 G/T cg01475377 chr6:109611718 NA -0.39 -5.27 -0.31 2.79e-7 Reticulocyte fraction of red cells; CESC cis rs9814567 0.964 rs4974480 chr3:134178562 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.37 -5.35 -0.31 1.9e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs763014 1.000 rs763014 chr16:675680 T/C cg09263875 chr16:632152 PIGQ 0.68 11.71 0.58 8.26e-26 Height; CESC cis rs34779708 0.897 rs11010131 chr10:35513316 A/C cg04310649 chr10:35416472 CREM -0.55 -6.38 -0.36 7.93e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs897984 0.568 rs67456613 chr16:30888295 G/A cg02466173 chr16:30829666 NA -0.48 -6.81 -0.39 6.53e-11 Dementia with Lewy bodies; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg02276107 chr5:61699841 DIMT1L -0.54 -6.39 -0.37 7.23e-10 Gut microbiota (bacterial taxa); CESC cis rs7927592 0.956 rs10896334 chr11:68281494 C/T cg16797656 chr11:68205561 LRP5 0.39 5.38 0.31 1.6e-7 Total body bone mineral density; CESC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg11890956 chr21:40555474 PSMG1 1.16 21.51 0.8 4.52e-60 Cognitive function; CESC cis rs8062405 0.755 rs4787457 chr16:28555400 A/G cg07382826 chr16:28625726 SULT1A1 0.39 6.39 0.37 7.35e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25011051 chr17:40718249 MLX;COASY -0.57 -6.85 -0.39 5.24e-11 Gut microbiome composition (summer); CESC cis rs1843834 0.505 rs4674911 chr2:225345254 A/G cg22509189 chr2:225307070 NA -0.39 -5.38 -0.31 1.67e-7 IgE levels in asthmatics (D.p. specific); CESC cis rs10752881 1.000 rs10911190 chr1:182979080 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Colorectal cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22131217 chr17:80348302 NA 0.54 7.4 0.41 1.77e-12 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24285721 chr7:44046988 SPDYE1;POLR2J4 -0.59 -7.2 -0.4 6.1e-12 Gut microbiome composition (summer); CESC cis rs7208859 0.573 rs216443 chr17:28931871 A/G cg13385521 chr17:29058706 SUZ12P 0.71 5.36 0.31 1.83e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11098499 0.874 rs6851169 chr4:120117510 T/C cg25214090 chr10:38739885 LOC399744 0.61 8.04 0.44 2.91e-14 Corneal astigmatism; CESC cis rs950776 0.506 rs12915366 chr15:78831753 G/A cg24631222 chr15:78858424 CHRNA5 -0.42 -5.35 -0.31 1.95e-7 Sudden cardiac arrest; CESC cis rs2425143 1.000 rs60646509 chr20:34303409 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -7.35 -0.41 2.49e-12 Blood protein levels; CESC cis rs763014 0.898 rs2017567 chr16:637212 T/C cg07343612 chr16:622815 PIGQ -0.55 -8.04 -0.44 3.08e-14 Height; CESC cis rs10899021 0.920 rs11236181 chr11:74345823 A/C cg25880958 chr11:74394337 NA -0.77 -8.02 -0.44 3.32e-14 Response to metformin (IC50); CESC cis rs2204008 0.715 rs11495369 chr12:38238673 T/C cg13010199 chr12:38710504 ALG10B 0.49 6.1 0.35 3.78e-9 Bladder cancer; CESC cis rs7124681 0.584 rs11039448 chr11:47918416 G/T cg20307385 chr11:47447363 PSMC3 -0.58 -7.99 -0.44 4.23e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25674709 chr12:105724273 C12orf75 0.66 7.54 0.42 7.36e-13 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.66 0.55 2.59e-22 Height; CESC cis rs965469 0.779 rs6051820 chr20:3365301 A/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.28 -0.31 2.63e-7 IFN-related cytopenia; CESC cis rs2274273 0.935 rs3818451 chr14:55621116 C/G cg04306507 chr14:55594613 LGALS3 0.28 5.54 0.32 7.17e-8 Protein biomarker; CESC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg17971929 chr21:40555470 PSMG1 0.88 12.99 0.62 3.45e-30 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25464034 chr11:450264 PTDSS2 -0.59 -6.85 -0.39 5.06e-11 Gut microbiome composition (summer); CESC cis rs12893668 0.703 rs12894729 chr14:104035292 G/A cg24130564 chr14:104152367 KLC1 -0.48 -5.87 -0.34 1.31e-8 Reticulocyte count; CESC cis rs34779708 0.931 rs7079498 chr10:35375344 C/T cg03585969 chr10:35415529 CREM 0.76 10.2 0.53 8.17e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs11229555 0.874 rs11229512 chr11:58286105 T/C cg15696309 chr11:58395628 NA -0.41 -5.03 -0.3 8.87e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs1775715 0.737 rs11817598 chr10:32206259 A/G cg26784012 chr10:32216390 ARHGAP12 0.39 5.16 0.3 4.96e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg23711669 chr6:146136114 FBXO30 0.99 14.89 0.68 7.3e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs2070997 0.607 rs2314342 chr9:133707362 A/G cg11464064 chr9:133710261 ABL1 0.68 7.77 0.43 1.79e-13 Response to amphetamines; CESC cis rs34734847 0.871 rs2239760 chr12:121163518 C/A cg21892295 chr12:121157589 UNC119B -0.39 -6.18 -0.36 2.38e-9 Mean corpuscular volume; CESC cis rs3857067 0.804 rs6821438 chr4:95091911 A/G cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.03 -0.48 3.74e-17 QT interval; CESC cis rs763121 0.853 rs3761454 chr22:39066820 C/T cg06022373 chr22:39101656 GTPBP1 0.87 13.83 0.65 4.07e-33 Menopause (age at onset); CESC cis rs28735056 0.572 rs4799100 chr18:77640207 A/G cg20368463 chr18:77673604 PQLC1 -0.4 -5.16 -0.3 4.87e-7 Schizophrenia; CESC cis rs2479724 0.846 rs1536702 chr6:41869950 T/A cg08135965 chr6:41755394 TOMM6 0.44 5.85 0.34 1.46e-8 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27327370 chr2:192746685 NA -0.65 -7.79 -0.43 1.5700000000000001e-13 Gut microbiome composition (summer); CESC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg25204440 chr1:209979598 IRF6 0.6 6.6 0.38 2.24e-10 Cleft lip with or without cleft palate; CESC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.85e-8 Aortic root size; CESC trans rs561341 0.714 rs111760509 chr17:30304320 A/G cg20587970 chr11:113659929 NA -1.4 -17.9 -0.74 1.64e-47 Hip circumference adjusted for BMI; CESC trans rs3942852 0.594 rs10769311 chr11:48094009 T/C cg03929089 chr4:120376271 NA -0.64 -7.91 -0.44 6.85e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs11295209 1 rs11295209 chr4:120480233 TA/T cg09307838 chr4:120376055 NA -0.55 -7.3 -0.41 3.43e-12 Plateletcrit; CESC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg05341575 chr12:125625032 AACS -0.37 -5.33 -0.31 2.12e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs7264396 0.673 rs2425163 chr20:34432670 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.46 -0.58 5.9e-25 Total cholesterol levels; CESC cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg12826209 chr6:26865740 GUSBL1 -0.71 -8.46 -0.46 1.79e-15 Intelligence (multi-trait analysis); CESC cis rs11690935 0.610 rs59844139 chr2:172731983 C/A cg13550731 chr2:172543902 DYNC1I2 0.5 6.97 0.39 2.48e-11 Schizophrenia; CESC cis rs1775715 0.737 rs2778672 chr10:32122419 T/C cg18675610 chr10:32216311 ARHGAP12 0.34 5.27 0.31 2.85e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg26335602 chr6:28129616 ZNF389 0.46 6.35 0.36 9.27e-10 Parkinson's disease; CESC cis rs9470366 0.545 rs4711457 chr6:36633160 T/C cg08179530 chr6:36648295 CDKN1A -0.62 -8.87 -0.48 1.1e-16 QRS duration; CESC cis rs13191362 0.507 rs2849511 chr6:163139050 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.59 -6.94 -0.39 3.07e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6088590 0.523 rs6088536 chr20:33189106 T/C cg08999081 chr20:33150536 PIGU 0.68 11.68 0.58 1.07e-25 Coronary artery disease; CESC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.63 0.64 1.97e-32 Prudent dietary pattern; CESC cis rs36051895 0.664 rs9695933 chr9:5153104 C/T cg02405213 chr9:5042618 JAK2 -0.54 -6.88 -0.39 4.4e-11 Pediatric autoimmune diseases; CESC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.58 0.37 2.49e-10 Prudent dietary pattern; CESC cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg03433033 chr1:76189801 ACADM 0.52 5.22 0.31 3.65e-7 Blood metabolite levels;Acylcarnitine levels; CESC cis rs734999 0.505 rs4278312 chr1:2539555 A/G cg20673091 chr1:2541236 MMEL1 0.46 7.82 0.43 1.24e-13 Ulcerative colitis; CESC cis rs9503598 0.636 rs6596976 chr6:3466022 C/T cg00476032 chr6:3446245 SLC22A23 0.35 5.75 0.33 2.45e-8 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); CESC cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg18252515 chr7:66147081 NA -1.29 -12.52 -0.61 1.5e-28 Diabetic kidney disease; CESC cis rs4450131 0.522 rs4962680 chr10:126358833 C/T cg20435097 chr10:126320824 FAM53B 0.29 5.18 0.3 4.31e-7 White blood cell count (basophil); CESC cis rs5750830 0.594 rs6001568 chr22:39775786 G/A cg02038168 chr22:39784481 NA -0.62 -7.79 -0.43 1.5e-13 Intelligence (multi-trait analysis); CESC cis rs7833986 0.534 rs2458083 chr8:56898785 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.16 0.4 8.04e-12 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23104930 chr12:133125882 FBRSL1 0.43 6.23 0.36 1.82e-9 Fibrinogen levels; CESC cis rs9926296 0.581 rs12598477 chr16:89902482 T/C cg03388025 chr16:89894329 SPIRE2 0.32 5.36 0.31 1.82e-7 Vitiligo; CESC cis rs1256061 0.646 rs1152588 chr14:64688175 G/C cg21174375 chr14:64681225 SYNE2 0.5 6.44 0.37 5.69e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9318086 0.687 rs9507182 chr13:24442365 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.43 5.92 0.34 9.83e-9 Myopia (pathological); CESC cis rs6963495 0.745 rs56239334 chr7:105165351 G/A cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg18350739 chr11:68623251 NA -0.44 -6.91 -0.39 3.56e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9911578 0.967 rs6503893 chr17:57149695 G/A cg12560992 chr17:57184187 TRIM37 1.02 17.98 0.74 8.31e-48 Intelligence (multi-trait analysis); CESC cis rs7208859 0.524 rs8065744 chr17:29099449 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg17178900 chr1:205818956 PM20D1 0.77 12.0 0.59 8.77e-27 Menarche (age at onset); CESC cis rs3820068 0.626 rs11580170 chr1:15909744 C/T cg17385448 chr1:15911702 AGMAT 0.42 6.64 0.38 1.77e-10 Systolic blood pressure; CESC cis rs60154123 0.615 rs701943 chr1:210425727 A/G cg22029157 chr1:209979665 IRF6 -0.5 -6.24 -0.36 1.68e-9 Coronary artery disease; CESC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1950626 0.623 rs35947256 chr14:101460366 G/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.67 8.48 0.46 1.58e-15 Pelvic organ prolapse (moderate/severe); CESC cis rs11577318 0.853 rs3795684 chr1:26632781 C/T cg00813993 chr1:26644493 UBXN11;CD52 -0.41 -6.51 -0.37 3.84e-10 Granulocyte percentage of myeloid white cells; CESC cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg23711669 chr6:146136114 FBXO30 -0.99 -15.26 -0.68 3.83e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs9462846 0.919 rs9462851 chr6:42890602 A/G cg02353165 chr6:42928485 GNMT 0.43 5.1 0.3 6.62e-7 Blood protein levels; CESC trans rs875971 1.000 rs6961155 chr7:65933295 T/C cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg18230493 chr5:56204884 C5orf35 -0.71 -8.8 -0.48 1.78e-16 Initial pursuit acceleration; CESC cis rs5771069 0.931 rs5771222 chr22:50445704 C/T cg27467552 chr22:50353597 PIM3 0.5 7.5 0.42 9.87e-13 Ulcerative colitis; CESC cis rs6982240 0.514 rs892362 chr8:142269214 A/G cg00131261 chr8:142287264 NA 0.51 7.31 0.41 3.24e-12 Tonsillectomy; CESC cis rs72634258 0.554 rs4908694 chr1:7850898 C/T cg26816564 chr1:7831052 VAMP3 0.66 6.13 0.35 3.21e-9 Inflammatory bowel disease; CESC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg06873352 chr17:61820015 STRADA 0.47 6.9 0.39 3.91e-11 Height; CESC cis rs1559088 0.576 rs7251626 chr19:33578470 C/A cg27124370 chr19:33622961 WDR88 0.54 7.8 0.43 1.4e-13 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.63 -8.04 -0.44 3.09e-14 Tonsillectomy; CESC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg09165964 chr15:75287851 SCAMP5 0.49 6.49 0.37 4.14e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC trans rs1814175 0.817 rs28679516 chr11:50055998 G/A cg15704280 chr7:45808275 SEPT13 -1.05 -21.04 -0.79 1.87e-58 Height; CESC cis rs4843747 0.671 rs72818576 chr16:88111019 C/G cg06374794 chr16:88002281 BANP 0.39 5.11 0.3 6.18e-7 Menopause (age at onset); CESC cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.87 -14.04 -0.65 7.75e-34 Hip circumference adjusted for BMI; CESC trans rs2230307 0.656 rs568089 chr1:100495392 A/G cg20664313 chr12:133071297 FBRSL1 -0.63 -6.15 -0.35 2.79e-9 Carotid intima media thickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05269546 chr19:50098360 PRR12 -0.63 -6.95 -0.39 2.83e-11 Gut microbiome composition (summer); CESC cis rs7520050 0.931 rs11576305 chr1:46460046 C/T cg03146154 chr1:46216737 IPP -0.48 -6.16 -0.35 2.71e-9 Red blood cell count;Reticulocyte count; CESC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg08736216 chr1:53307985 ZYG11A 0.43 7.24 0.41 4.86e-12 Monocyte count; CESC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -5.73 -0.33 2.66e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6496667 0.509 rs6496677 chr15:90990358 A/G cg22089800 chr15:90895588 ZNF774 0.44 5.68 0.33 3.51e-8 Rheumatoid arthritis; CESC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg08027265 chr7:2291960 NA 0.33 5.03 0.3 8.92e-7 Bipolar disorder and schizophrenia; CESC cis rs2439831 0.867 rs28729853 chr15:43673680 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.91 11.14 0.56 6.61e-24 Lung cancer in ever smokers; CESC cis rs6500602 0.592 rs7206782 chr16:4515145 A/C cg08645402 chr16:4508243 NA 0.43 6.45 0.37 5.38e-10 Schizophrenia; CESC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg20151795 chr6:28129481 ZNF389 0.49 6.51 0.37 3.71e-10 Depression; CESC cis rs8180040 0.764 rs13062022 chr3:47169375 G/A cg27129171 chr3:47204927 SETD2 0.7 10.54 0.54 6.49e-22 Colorectal cancer; CESC cis rs10489202 1.000 rs17556487 chr1:167889094 T/A cg24449463 chr1:168025552 DCAF6 -0.47 -5.38 -0.31 1.62e-7 Schizophrenia; CESC cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg12927641 chr6:109611667 NA -0.44 -6.83 -0.39 5.89e-11 Reticulocyte fraction of red cells; CESC cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.87 8.68 0.47 4.04e-16 Schizophrenia; CESC cis rs1448094 0.511 rs17279240 chr12:86162550 A/T cg02569458 chr12:86230093 RASSF9 0.49 7.68 0.43 3.15e-13 Major depressive disorder; CESC cis rs7959452 0.570 rs10878964 chr12:69720691 T/G cg14784868 chr12:69753453 YEATS4 0.72 10.26 0.53 5.09e-21 Blood protein levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06264303 chr10:38299291 ZNF33A 0.51 6.88 0.39 4.36e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.44 0.42 1.43e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs820218 0.926 rs820211 chr17:73650686 A/C cg01592526 chr17:73663357 RECQL5;SAP30BP -0.41 -5.5 -0.32 8.99e-8 Rotator cuff tears; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg11668448 chr8:124054817 DERL1 -0.5 -6.49 -0.37 4.2e-10 Height; CESC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg18876405 chr7:65276391 NA 0.7 9.76 0.51 2.02e-19 Calcium levels; CESC cis rs372883 0.624 rs1153286 chr21:30684383 A/G cg24692254 chr21:30365293 RNF160 -0.49 -6.17 -0.35 2.52e-9 Pancreatic cancer; CESC cis rs9660992 0.573 rs12126439 chr1:205200720 C/T cg00857998 chr1:205179979 DSTYK 0.56 6.88 0.39 4.29e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.64 -0.51 4.86e-19 Alzheimer's disease; CESC cis rs9486719 0.741 rs2499799 chr6:96851676 T/C cg18709589 chr6:96969512 KIAA0776 0.55 5.77 0.33 2.19e-8 Migraine;Coronary artery disease; CESC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg15595755 chr5:1867978 NA 0.55 9.05 0.49 3.23e-17 Cardiovascular disease risk factors; CESC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.09e-10 Bipolar disorder; CESC trans rs11992162 0.560 rs7846248 chr8:11794049 T/A cg15556689 chr8:8085844 FLJ10661 0.49 6.07 0.35 4.52e-9 Monocyte count; CESC trans rs1545843 0.623 rs11116359 chr12:84791075 A/G cg03015433 chr16:56623111 MT3 -0.33 -6.02 -0.35 5.66e-9 Major depressive disorder; CESC cis rs10751667 0.600 rs6597948 chr11:1005308 C/T cg20946044 chr11:1010712 AP2A2 -0.51 -6.93 -0.39 3.23e-11 Alzheimer's disease (late onset); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg20843052 chr2:61293725 KIAA1841 0.42 6.13 0.35 3.2e-9 Systemic lupus erythematosus; CESC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg10800226 chr5:1850261 NA 0.33 5.33 0.31 2.14e-7 Cardiovascular disease risk factors; CESC cis rs1707322 1.000 rs10890377 chr1:46406594 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg20566420 chr12:122327043 PSMD9 0.48 6.21 0.36 2.05e-9 Systemic lupus erythematosus; CESC trans rs6535028 0.803 rs4565134 chr4:135456548 C/T cg04198210 chr15:74528606 CCDC33 -0.6 -6.14 -0.35 3.07e-9 Response to radiotherapy in prostate cancer (overall toxicity); CESC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg18337363 chr3:52569053 NT5DC2 0.3 5.58 0.32 5.86e-8 Electroencephalogram traits; CESC cis rs3126085 0.935 rs12760382 chr1:152260287 G/T cg03465714 chr1:152285911 FLG 0.5 5.98 0.34 7.27e-9 Atopic dermatitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12032620 chr15:43802735 TP53BP1 -0.61 -7.37 -0.41 2.12e-12 Gut microbiome composition (summer); CESC cis rs2996428 0.628 rs6667526 chr1:3774603 G/A cg13057898 chr1:3703894 LRRC47 0.45 6.14 0.35 3.05e-9 Red cell distribution width; CESC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg13628971 chr7:2884303 GNA12 0.63 8.5 0.46 1.42e-15 Height; CESC cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.05 9.74 0.51 2.3e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6582630 0.502 rs1915395 chr12:38420726 A/G cg26384229 chr12:38710491 ALG10B 0.73 10.75 0.55 1.27e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs1707322 1.000 rs7547189 chr1:46319514 C/A cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2933343 0.679 rs789229 chr3:128602526 C/T cg25356066 chr3:128598488 ACAD9 0.66 9.18 0.49 1.27e-17 IgG glycosylation; CESC cis rs7208859 0.673 rs9895815 chr17:29138033 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06714758 chr12:57881796 MARS 0.59 7.04 0.4 1.6e-11 Gut microbiome composition (summer); CESC cis rs9399135 0.967 rs4637662 chr6:135298158 T/C cg22676075 chr6:135203613 NA 0.52 7.21 0.4 5.94e-12 Red blood cell count; CESC trans rs3942852 0.726 rs10742836 chr11:48175831 G/A cg03929089 chr4:120376271 NA -0.66 -7.24 -0.41 4.83e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs2294693 0.679 rs12200923 chr6:40970092 T/G cg14418226 chr6:40996092 UNC5CL 0.49 5.3 0.31 2.43e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg20476274 chr7:133979776 SLC35B4 0.67 9.79 0.52 1.65e-19 Mean platelet volume; CESC cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg22875332 chr1:76189707 ACADM 0.65 7.87 0.44 8.9e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2274273 0.624 rs7151754 chr14:55788501 C/T cg04306507 chr14:55594613 LGALS3 0.29 5.1 0.3 6.54e-7 Protein biomarker; CESC cis rs7100689 0.646 rs4357632 chr10:82131783 C/T cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs6812193 0.518 rs77937770 chr4:77193208 A/T cg20311846 chr4:77356250 SHROOM3 0.3 5.26 0.31 3.01e-7 Parkinson's disease; CESC cis rs2573652 0.722 rs8041337 chr15:100541808 T/C cg00587665 chr15:100533223 ADAMTS17 -0.4 -6.49 -0.37 4.1e-10 Height; CESC cis rs863345 0.565 rs7551497 chr1:158444925 T/G cg12129480 chr1:158549410 OR10X1 -0.36 -7.18 -0.4 7.1e-12 Pneumococcal bacteremia; CESC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg24209194 chr3:40518798 ZNF619 0.51 6.26 0.36 1.51e-9 Renal cell carcinoma; CESC cis rs7555523 0.887 rs10918274 chr1:165714416 T/C cg24409356 chr1:165738333 TMCO1 0.97 8.67 0.47 4.48e-16 Intraocular pressure;Glaucoma (high intraocular pressure); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg16941144 chr14:45603841 FKBP3;FANCM -0.46 -6.01 -0.35 6.24e-9 Thyroid stimulating hormone; CESC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg27572855 chr1:25598939 RHD -0.44 -7.22 -0.41 5.41e-12 Erythrocyte sedimentation rate; CESC cis rs643506 0.845 rs607327 chr11:111695709 C/T cg09085632 chr11:111637200 PPP2R1B 0.41 5.4 0.31 1.46e-7 Breast cancer; CESC cis rs6493487 0.512 rs17521467 chr15:51214926 T/C cg02338191 chr15:51200825 AP4E1 0.6 5.57 0.32 6.13e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs477692 0.673 rs10764889 chr10:131341521 G/A cg24747557 chr10:131355152 MGMT -0.39 -5.38 -0.31 1.67e-7 Response to temozolomide; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19041146 chr11:118401536 TMEM25;TTC36 0.62 7.51 0.42 9.27e-13 Gut microbiome composition (summer); CESC cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg00825309 chr19:58991885 ZNF446 -0.55 -7.97 -0.44 4.68e-14 Uric acid clearance; CESC cis rs17376456 0.825 rs17314825 chr5:93234937 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.58 5.09 0.3 6.7e-7 Diabetic retinopathy; CESC cis rs3768617 0.811 rs10797828 chr1:183028430 G/A ch.1.3577855R chr1:183094577 LAMC1 0.66 9.09 0.49 2.4e-17 Fuchs's corneal dystrophy; CESC cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg15556689 chr8:8085844 FLJ10661 0.45 5.5 0.32 8.79e-8 Mood instability; CESC cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg19912559 chr1:40204330 PPIE 0.4 6.02 0.35 5.65e-9 Blood protein levels; CESC cis rs7659604 0.502 rs28522256 chr4:122709266 C/T cg19748678 chr4:122722346 EXOSC9 -0.42 -5.26 -0.31 2.97e-7 Type 2 diabetes; CESC cis rs2637266 1.000 rs12414151 chr10:78359041 T/G cg18941641 chr10:78392320 NA 0.42 7.87 0.44 9.04e-14 Pulmonary function; CESC cis rs10887741 0.646 rs7097212 chr10:89430067 G/A cg13926569 chr10:89418898 PAPSS2 0.47 7.23 0.41 5.14e-12 Exercise (leisure time); CESC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.36 0.31 1.8e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3026101 0.671 rs929262 chr17:5312271 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs9811920 0.893 rs6798114 chr3:99892825 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.41 6.79 0.38 7.45e-11 Axial length; CESC cis rs7617480 0.648 rs9864243 chr3:48982732 G/A cg07636037 chr3:49044803 WDR6 0.89 11.66 0.58 1.28e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg17221315 chr6:27791827 HIST1H4J 0.43 5.15 0.3 4.98e-7 Parkinson's disease; CESC cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg17414380 chr19:19431394 KIAA0892;SF4 0.49 6.26 0.36 1.5e-9 Tonsillectomy; CESC cis rs11122272 0.735 rs2486746 chr1:231497324 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.83 0.34 1.65e-8 Hemoglobin concentration; CESC cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9322193 0.923 rs9322197 chr6:149943713 C/A cg07701084 chr6:150067640 NUP43 0.41 5.67 0.33 3.74e-8 Lung cancer; CESC cis rs7914558 1.000 rs67908413 chr10:104764989 T/C cg15744005 chr10:104629667 AS3MT -0.34 -5.54 -0.32 7.28e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg24562669 chr7:97807699 LMTK2 0.51 7.53 0.42 7.86e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -7.78 -0.43 1.59e-13 Personality dimensions; CESC cis rs9325144 0.723 rs3887436 chr12:39189526 A/C cg26384229 chr12:38710491 ALG10B -0.51 -7.23 -0.41 5.23e-12 Morning vs. evening chronotype; CESC cis rs854765 0.623 rs9893690 chr17:17753846 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.55 -7.91 -0.44 6.9e-14 Total body bone mineral density; CESC cis rs9486719 0.843 rs976357 chr6:96849679 C/T cg06623918 chr6:96969491 KIAA0776 0.77 7.27 0.41 4.05e-12 Migraine;Coronary artery disease; CESC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.07 0.53 2.04e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg01475377 chr6:109611718 NA -0.52 -8.64 -0.47 5.27e-16 Reticulocyte fraction of red cells; CESC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg08736216 chr1:53307985 ZYG11A 0.43 7.25 0.41 4.64e-12 Monocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16876192 chr8:144550601 ZC3H3 0.52 7.18 0.4 6.83e-12 Fibrinogen levels; CESC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg24829409 chr8:58192753 C8orf71 -0.69 -7.54 -0.42 7.35e-13 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13482925 chr10:64028750 RTKN2 0.52 6.51 0.37 3.65e-10 Gut microbiota (bacterial taxa); CESC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.42 -0.5 2.37e-18 Alzheimer's disease; CESC cis rs2354432 0.556 rs7520661 chr1:146793149 A/G cg25205988 chr1:146714368 CHD1L -0.9 -7.67 -0.43 3.18e-13 Mitochondrial DNA levels; CESC cis rs854765 0.604 rs12948749 chr17:17949802 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.5 -6.89 -0.39 4.14e-11 Total body bone mineral density; CESC cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg15782153 chr7:917662 C7orf20 0.52 5.79 0.34 1.98e-8 Cerebrospinal P-tau181p levels; CESC cis rs116095464 0.558 rs28418643 chr5:240859 A/G cg22496380 chr5:211416 CCDC127 -0.75 -8.78 -0.47 2.13e-16 Breast cancer; CESC cis rs16866061 1.000 rs72974267 chr2:225454209 T/C cg12698349 chr2:225449008 CUL3 0.72 10.66 0.55 2.62e-22 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg02807482 chr3:125708958 NA -0.4 -5.25 -0.31 3.09e-7 Blood pressure (smoking interaction); CESC cis rs9916302 0.752 rs6503513 chr17:37561613 A/G cg15445000 chr17:37608096 MED1 -0.36 -5.28 -0.31 2.71e-7 Glomerular filtration rate (creatinine); CESC cis rs737337 0.623 rs3826815 chr19:11332505 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.52 5.29 0.31 2.63e-7 HDL cholesterol;HDL cholesterol levels; CESC cis rs4253772 0.530 rs11090875 chr22:46785301 C/T cg09491104 chr22:46646882 C22orf40 -0.54 -5.23 -0.31 3.44e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg22875332 chr1:76189707 ACADM 0.68 8.92 0.48 7.66e-17 Blood metabolite levels;Acylcarnitine levels; CESC cis rs8002861 0.905 rs12875052 chr13:44449368 G/C cg19180546 chr13:44453867 C13orf31;CCDC122 -0.46 -5.81 -0.34 1.82e-8 Leprosy; CESC cis rs3126085 0.935 rs12729662 chr1:152185750 G/A cg26876637 chr1:152193138 HRNR -0.45 -5.09 -0.3 6.95e-7 Atopic dermatitis; CESC cis rs155076 0.711 rs4770129 chr13:21882059 T/G cg25811766 chr13:21894605 NA 0.56 5.64 0.33 4.32e-8 White matter hyperintensity burden; CESC cis rs9814567 1.000 rs1880376 chr3:134270347 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg05332525 chr7:65337924 VKORC1L1 -0.48 -5.91 -0.34 1.06e-8 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09593402 chr5:96270297 LNPEP -0.44 -6.24 -0.36 1.7e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09688494 chr10:14996222 DCLRE1C 0.55 6.37 0.36 8.39e-10 Gut microbiome composition (summer); CESC cis rs9399135 0.933 rs41294852 chr6:135376379 T/G cg24558204 chr6:135376177 HBS1L 0.52 7.03 0.4 1.73e-11 Red blood cell count; CESC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg13206674 chr6:150067644 NUP43 0.43 6.15 0.35 2.86e-9 Lung cancer; CESC cis rs1707322 1.000 rs10158032 chr1:46332701 T/C cg05343316 chr1:45956843 TESK2 0.44 5.5 0.32 9.15e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3925075 1.000 rs12923297 chr16:31360944 T/C cg02846316 chr16:31340340 ITGAM 0.42 6.56 0.37 2.87e-10 IgA nephropathy; CESC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg18252515 chr7:66147081 NA -0.46 -6.09 -0.35 4.04e-9 Aortic root size; CESC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.51e-24 Menopause (age at onset); CESC trans rs11098499 0.954 rs6834796 chr4:120414693 A/C cg25214090 chr10:38739885 LOC399744 0.72 10.09 0.53 1.85e-20 Corneal astigmatism; CESC cis rs7605827 0.930 rs1997307 chr2:15512588 T/C cg19274914 chr2:15703543 NA 0.31 5.51 0.32 8.7e-8 Educational attainment (years of education); CESC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Parkinson's disease; CESC cis rs7937682 0.924 rs501089 chr11:111502479 G/T cg22437258 chr11:111473054 SIK2 -0.59 -6.85 -0.39 5e-11 Primary sclerosing cholangitis; CESC cis rs116095464 0.558 rs7731089 chr5:290422 A/C cg20965017 chr5:231967 SDHA -0.46 -5.2 -0.3 4.02e-7 Breast cancer; CESC cis rs6460942 0.915 rs75732743 chr7:12454095 C/T cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs11252926 0.527 rs10904093 chr10:436848 A/G cg18196295 chr10:418757 DIP2C -0.53 -7.31 -0.41 3.17e-12 Psychosis in Alzheimer's disease; CESC cis rs7818688 1.000 rs10098453 chr8:96029756 A/G cg16049864 chr8:95962084 TP53INP1 -0.59 -5.74 -0.33 2.58e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs72781680 0.948 rs72781652 chr2:24213754 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.58 0.32 6.04e-8 Lymphocyte counts; CESC cis rs4547160 0.606 rs36108998 chr12:63477075 T/C cg26727693 chr12:63544175 AVPR1A -0.35 -5.24 -0.31 3.31e-7 Morning vs. evening chronotype; CESC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg11890956 chr21:40555474 PSMG1 1.18 22.66 0.81 6.1e-64 Cognitive function; CESC cis rs10242455 0.867 rs2687145 chr7:99318644 C/T cg07715041 chr7:99302981 CYP3A7 0.42 5.36 0.31 1.77e-7 Blood metabolite levels; CESC cis rs10129255 0.957 rs10136781 chr14:107188690 G/T cg07958169 chr14:107095056 NA -0.4 -5.54 -0.32 7.3e-8 Kawasaki disease; CESC cis rs524281 0.861 rs10896086 chr11:65914764 T/A cg14036092 chr11:66035641 RAB1B -0.58 -5.78 -0.33 2.12e-8 Electroencephalogram traits; CESC cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg23711669 chr6:146136114 FBXO30 -1.01 -15.7 -0.69 1.03e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg22535103 chr8:58192502 C8orf71 -1.04 -12.87 -0.62 9.04e-30 Developmental language disorder (linguistic errors); CESC cis rs16854884 0.586 rs13081286 chr3:143723757 A/T cg06585982 chr3:143692056 C3orf58 0.5 6.79 0.39 7.29e-11 Economic and political preferences (feminism/equality); CESC cis rs62005083 1.000 rs72725929 chr14:74536731 C/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.7 5.23 0.31 3.51e-7 Mean corpuscular volume; CESC cis rs911555 0.692 rs7140647 chr14:103893465 A/G cg24130564 chr14:104152367 KLC1 0.49 6.51 0.37 3.78e-10 Intelligence (multi-trait analysis); CESC cis rs4975616 0.869 rs466502 chr5:1325767 C/T cg06550200 chr5:1325588 CLPTM1L 0.69 11.11 0.56 8.36e-24 Lung cancer; CESC cis rs79839061 0.610 rs11731387 chr4:851357 C/T cg07828340 chr4:882639 GAK 0.88 7.17 0.4 7.28e-12 Intelligence (multi-trait analysis); CESC cis rs4975616 0.686 rs37011 chr5:1348798 A/T cg06550200 chr5:1325588 CLPTM1L -0.63 -9.49 -0.5 1.42e-18 Lung cancer; CESC trans rs6600671 0.967 rs11249349 chr1:121179169 G/C cg17023122 chr1:144479586 NA 0.45 6.25 0.36 1.63e-9 Hip geometry; CESC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.2e-17 Prudent dietary pattern; CESC cis rs9916302 0.904 rs68178216 chr17:37526241 A/C cg00129232 chr17:37814104 STARD3 0.52 6.49 0.37 4.19e-10 Glomerular filtration rate (creatinine); CESC cis rs35110281 0.594 rs230641 chr21:44915441 T/C cg04455712 chr21:45112962 RRP1B -0.35 -5.44 -0.32 1.19e-7 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10487699 chr11:57480176 TMX2;MED19 0.53 6.0 0.35 6.35e-9 Gut microbiome composition (summer); CESC cis rs6430585 0.528 rs309159 chr2:136684940 C/T cg07169764 chr2:136633963 MCM6 1.09 15.21 0.68 5.48e-38 Corneal structure; CESC cis rs921968 0.541 rs4674310 chr2:219318078 T/C cg02176678 chr2:219576539 TTLL4 -0.53 -9.28 -0.5 6.12e-18 Mean corpuscular hemoglobin concentration; CESC cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg00074818 chr8:8560427 CLDN23 0.38 5.46 0.32 1.1e-7 Obesity-related traits; CESC cis rs2380220 0.935 rs7744491 chr6:95994980 T/G cg15832292 chr6:96025679 MANEA 0.7 6.74 0.38 9.99e-11 Behavioural disinhibition (generation interaction); CESC cis rs6500395 1.000 rs12599028 chr16:48713082 C/A cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3857536 0.740 rs9354390 chr6:66890162 C/T cg07460842 chr6:66804631 NA 0.43 5.48 0.32 9.68e-8 Blood trace element (Cu levels); CESC cis rs9488822 0.596 rs6568921 chr6:116373616 C/T cg05304507 chr6:116381966 FRK 0.23 5.61 0.33 5.1e-8 Cholesterol, total;LDL cholesterol; CESC cis rs3806843 1.000 rs1030164 chr5:140185272 A/G cg26395211 chr5:140044315 WDR55 -0.42 -5.25 -0.31 3.16e-7 Depressive symptoms (multi-trait analysis); CESC cis rs17209837 0.607 rs4148816 chr7:87087731 G/A cg00919237 chr7:87102261 ABCB4 -0.51 -6.58 -0.37 2.45e-10 Gallbladder cancer; CESC cis rs3747547 0.892 rs72726021 chr9:38010435 A/G cg13774184 chr9:37916125 SHB -0.73 -6.25 -0.36 1.61e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs28374715 0.578 rs17730888 chr15:41637547 A/G cg18705301 chr15:41695430 NDUFAF1 -1.03 -16.13 -0.7 2.98e-41 Ulcerative colitis; CESC cis rs6121246 0.559 rs6087771 chr20:30306724 A/G cg13852791 chr20:30311386 BCL2L1 0.87 11.45 0.58 6.29e-25 Mean corpuscular hemoglobin; CESC cis rs2243480 0.803 rs423187 chr7:65509499 G/C cg13147721 chr7:65941812 NA -0.96 -9.02 -0.48 3.98e-17 Diabetic kidney disease; CESC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg18446336 chr7:2847575 GNA12 -0.4 -6.1 -0.35 3.79e-9 Height; CESC cis rs1707322 0.686 rs3014251 chr1:46077428 G/C cg03146154 chr1:46216737 IPP -0.79 -10.71 -0.55 1.73e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs738322 0.967 rs4383 chr22:38570927 C/G cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27037969 chr12:125549952 AACS 0.64 7.79 0.43 1.5e-13 Gut microbiome composition (summer); CESC cis rs1707322 0.721 rs12037803 chr1:46156492 A/G cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9811920 0.965 rs9289981 chr3:99868104 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.43 7.12 0.4 1.04e-11 Axial length; CESC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg18337363 chr3:52569053 NT5DC2 0.29 5.3 0.31 2.43e-7 Intelligence (multi-trait analysis); CESC cis rs6484504 0.600 rs10835763 chr11:31345574 G/A cg14844989 chr11:31128820 NA 0.39 5.5 0.32 8.77e-8 Red blood cell count; CESC cis rs36051895 0.589 rs4560849 chr9:5203866 C/G cg02405213 chr9:5042618 JAK2 -0.49 -5.68 -0.33 3.54e-8 Pediatric autoimmune diseases; CESC cis rs4727027 0.901 rs66800495 chr7:148763702 T/C cg23583168 chr7:148888333 NA -0.78 -11.74 -0.59 6.48e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4727027 0.899 rs6464942 chr7:148826368 T/C cg23158103 chr7:148848205 ZNF398 -0.4 -6.34 -0.36 9.68e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9398803 0.965 rs9388489 chr6:126698719 C/T cg19875578 chr6:126661172 C6orf173 -0.5 -6.96 -0.39 2.74e-11 Male-pattern baldness; CESC cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05772935 chr16:1790400 MAPK8IP3 -0.66 -7.2 -0.4 6.03e-12 Gut microbiome composition (summer); CESC cis rs1707322 0.717 rs10890345 chr1:46213927 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs372883 0.563 rs1153293 chr21:30691325 C/T cg08807101 chr21:30365312 RNF160 0.45 5.07 0.3 7.48e-7 Pancreatic cancer; CESC cis rs3820068 0.581 rs56128111 chr1:15928948 T/G cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs2243480 1.000 rs313820 chr7:65574466 A/C cg13147721 chr7:65941812 NA -0.99 -9.36 -0.5 3.5e-18 Diabetic kidney disease; CESC cis rs36051895 0.530 rs60768043 chr9:5224676 T/G cg02405213 chr9:5042618 JAK2 -0.54 -6.13 -0.35 3.22e-9 Pediatric autoimmune diseases; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07790826 chr11:70049435 FADD -0.48 -6.09 -0.35 4.02e-9 Fibrinogen levels; CESC cis rs10789491 0.767 rs1816730 chr1:47207346 T/C cg15501359 chr1:47185051 KIAA0494 0.76 7.4 0.41 1.82e-12 Response to hepatitis C treatment; CESC cis rs2072499 0.932 rs2736613 chr1:156196016 T/C cg25208724 chr1:156163844 SLC25A44 0.94 15.31 0.69 2.4e-38 Testicular germ cell tumor; CESC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 12.9 0.62 7.34e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11711311 0.712 rs6795099 chr3:113338782 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.31 0.36 1.14e-9 IgG glycosylation; CESC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg03388025 chr16:89894329 SPIRE2 0.42 8.14 0.45 1.52e-14 Vitiligo; CESC cis rs113835537 0.529 rs11227501 chr11:66274072 T/C cg22134325 chr11:66188745 NPAS4 0.35 5.57 0.32 6.29e-8 Airway imaging phenotypes; CESC cis rs6598955 0.671 rs12129482 chr1:26623641 C/T cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.45 0.32 1.18e-7 Obesity-related traits; CESC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg20151795 chr6:28129481 ZNF389 0.45 5.7 0.33 3.12e-8 Depression; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07318050 chr1:233086124 C1orf57 -0.48 -6.9 -0.39 3.87e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7264396 0.635 rs6058363 chr20:34505054 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.54 6.97 0.39 2.49e-11 Total cholesterol levels; CESC cis rs3733585 0.638 rs28715627 chr4:9958140 T/A cg00071950 chr4:10020882 SLC2A9 -0.72 -11.7 -0.58 8.89e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs72781680 1.000 rs72781654 chr2:24218099 T/C cg08917208 chr2:24149416 ATAD2B 0.55 5.38 0.31 1.62e-7 Lymphocyte counts; CESC cis rs4253772 0.550 rs739164 chr22:46684558 C/T cg09491104 chr22:46646882 C22orf40 0.59 8.75 0.47 2.54e-16 LDL cholesterol;Cholesterol, total; CESC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -6.71 -0.38 1.18e-10 Bipolar disorder; CESC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg07153921 chr17:41440717 NA 0.41 5.54 0.32 7.13e-8 Menopause (age at onset); CESC cis rs72781680 0.898 rs10490751 chr2:24001356 A/G cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Depression; CESC cis rs2865126 0.818 rs7227167 chr18:10763007 A/G cg21165219 chr18:10698044 FAM38B -0.49 -5.17 -0.3 4.69e-7 Metabolite levels (5-HIAA/ MHPG Ratio); CESC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg22442454 chr1:209979470 IRF6 0.5 6.13 0.35 3.17e-9 Cleft lip with or without cleft palate; CESC cis rs2228479 0.618 rs17233623 chr16:89811209 C/T cg00800038 chr16:89945340 TCF25 -0.77 -7.17 -0.4 7.39e-12 Skin colour saturation; CESC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg27286337 chr10:134555280 INPP5A 0.68 7.69 0.43 2.81e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4076764 1.000 rs12740984 chr1:163422151 A/G cg24596788 chr1:163392923 NA 0.49 7.22 0.41 5.38e-12 Motion sickness; CESC cis rs11608355 0.521 rs10850131 chr12:109837052 A/G cg19025524 chr12:109796872 NA 0.52 7.33 0.41 2.87e-12 Neuroticism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15871229 chr10:74451622 CCDC109A 0.46 6.79 0.38 7.47e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -11.61 -0.58 1.83e-25 Alzheimer's disease; CESC trans rs116095464 0.558 rs28636067 chr5:199415 G/A cg00938859 chr5:1591904 SDHAP3 0.65 6.14 0.35 3.05e-9 Breast cancer; CESC cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.48 -6.38 -0.37 7.67e-10 Personality dimensions; CESC cis rs10078 0.515 rs890984 chr5:479540 A/G cg08916839 chr5:415575 AHRR 0.59 6.89 0.39 4.17e-11 Fat distribution (HIV); CESC cis rs3784262 1.000 rs7170896 chr15:58252393 T/A cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.19 -0.3 4.29e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs6912958 0.712 rs6454640 chr6:88370352 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.55 7.46 0.42 1.21e-12 Monocyte percentage of white cells; CESC cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg27398817 chr8:82754497 SNX16 0.52 6.12 0.35 3.39e-9 Diastolic blood pressure; CESC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg19077165 chr18:44547161 KATNAL2 -0.55 -7.97 -0.44 4.8e-14 Personality dimensions; CESC cis rs911555 0.713 rs10162425 chr14:103931621 C/T cg09975044 chr14:104007538 NA 0.44 5.49 0.32 9.22e-8 Intelligence (multi-trait analysis); CESC cis rs4595586 0.545 rs6580892 chr12:39370237 G/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC trans rs78049276 0.512 rs7659823 chr4:148398877 C/G cg13149281 chr14:23389818 RBM23;PRMT5 -0.74 -10.31 -0.54 3.56e-21 Pulse pressure; CESC cis rs727563 0.555 rs5751136 chr22:42075581 T/A cg06634786 chr22:41940651 POLR3H 0.56 5.99 0.35 6.82e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs6674176 0.542 rs803675 chr1:44353237 G/A cg12908607 chr1:44402522 ARTN -0.39 -5.22 -0.31 3.64e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7824557 0.628 rs7008205 chr8:11197323 T/G cg21775007 chr8:11205619 TDH 0.58 9.28 0.5 6.25e-18 Retinal vascular caliber; CESC cis rs2204008 0.591 rs11495396 chr12:38380182 C/T cg26384229 chr12:38710491 ALG10B 0.73 11.15 0.57 6.25e-24 Bladder cancer; CESC cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg05347473 chr6:146136440 FBXO30 0.53 6.85 0.39 5.18e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs4932480 0.522 rs979171 chr15:89755448 A/C cg24069674 chr6:27230661 NA -0.42 -6.21 -0.36 2.09e-9 Advanced age-related macular degeneration;Age-related macular degeneration (SNP x mitochondrial G12771A interaction); CESC cis rs9916302 0.904 rs10221223 chr17:37489100 T/G cg07936489 chr17:37558343 FBXL20 0.77 10.62 0.55 3.6e-22 Glomerular filtration rate (creatinine); CESC trans rs2658782 1.000 rs2019814 chr11:93168885 A/G cg13657970 chr12:123333035 HIP1R 0.45 6.08 0.35 4.17e-9 Pulmonary function decline; CESC cis rs911555 0.755 rs17841064 chr14:103900609 A/G cg12935359 chr14:103987150 CKB -0.57 -8.38 -0.46 3.16e-15 Intelligence (multi-trait analysis); CESC cis rs7000551 0.751 rs2449341 chr8:22390937 C/A cg12081754 chr8:22256438 SLC39A14 0.41 5.44 0.32 1.22e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs7818345 0.512 rs4922028 chr8:19303771 C/T cg11303988 chr8:19266685 CSGALNACT1 0.32 5.25 0.31 3.09e-7 Language performance in older adults (adjusted for episodic memory); CESC cis rs5997397 0.934 rs6005864 chr22:29157487 A/G cg15103426 chr22:29168792 CCDC117 -0.49 -6.2 -0.36 2.2e-9 Red cell distribution width; CESC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs5769765 0.865 rs4824108 chr22:50271428 A/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs796364 0.806 rs11684942 chr2:201009136 C/T cg23649088 chr2:200775458 C2orf69 -0.55 -5.04 -0.3 8.69e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05187422 chr16:89597159 SPG7 -0.51 -6.28 -0.36 1.41e-9 Gut microbiome composition (summer); CESC cis rs9837602 0.882 rs9875664 chr3:99729130 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 7.09 0.4 1.2e-11 Breast cancer; CESC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg24562669 chr7:97807699 LMTK2 -0.51 -7.49 -0.42 1.02e-12 Prostate cancer (SNP x SNP interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04724143 chr13:114185494 TMCO3 0.49 6.83 0.39 5.89e-11 Fibrinogen levels; CESC cis rs7903847 0.642 rs9888117 chr10:99159963 C/G cg20016023 chr10:99160130 RRP12 -0.29 -5.04 -0.3 8.66e-7 Granulocyte percentage of myeloid white cells; CESC cis rs6545883 0.931 rs12713438 chr2:61725501 G/A cg15711740 chr2:61764176 XPO1 -0.42 -5.28 -0.31 2.64e-7 Tuberculosis; CESC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg27170947 chr2:26402098 FAM59B -0.82 -9.61 -0.51 6.07e-19 Gut microbiome composition (summer); CESC cis rs9486719 0.895 rs3798294 chr6:97049587 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -8.38 -0.46 3.18e-15 Migraine;Coronary artery disease; CESC cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg11644478 chr21:40555479 PSMG1 0.61 8.24 0.45 7.75e-15 Cognitive function; CESC cis rs2996428 0.561 rs16824192 chr1:3748605 G/A cg10555106 chr1:3691387 LOC388588 0.37 5.4 0.31 1.46e-7 Red cell distribution width; CESC cis rs9543976 0.623 rs7317250 chr13:76167141 C/T cg01531495 chr13:76123901 UCHL3 0.49 5.12 0.3 5.78e-7 Diabetic retinopathy; CESC cis rs76533333 0.564 rs34658917 chr13:113417423 C/T cg08557188 chr13:113420371 ATP11A -0.75 -5.12 -0.3 5.83e-7 Red cell distribution width; CESC cis rs478304 0.934 rs603645 chr11:65533000 A/C cg08755490 chr11:65554678 OVOL1 0.46 6.15 0.35 2.85e-9 Acne (severe); CESC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 9.38 0.5 3.07e-18 Platelet count; CESC cis rs61931739 0.517 rs7139189 chr12:34319757 T/C cg06521331 chr12:34319734 NA -0.45 -6.14 -0.35 3.03e-9 Morning vs. evening chronotype; CESC cis rs7312933 0.612 rs10785334 chr12:42620377 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.41 -5.27 -0.31 2.84e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6662572 0.737 rs9429091 chr1:46513088 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 5.41 0.32 1.38e-7 Blood protein levels; CESC cis rs992157 0.710 rs6752254 chr2:219058743 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.65 8.76 0.47 2.32e-16 Colorectal cancer; CESC cis rs78707713 0.560 rs12784882 chr10:71230334 C/G cg12610070 chr10:71211762 TSPAN15 -0.33 -6.85 -0.39 5.18e-11 Venous thromboembolism; CESC cis rs4319547 0.626 rs12423420 chr12:122938466 G/A cg05707623 chr12:122985044 ZCCHC8 -0.49 -6.04 -0.35 5.19e-9 Body mass index; CESC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg04267008 chr7:1944627 MAD1L1 0.49 6.06 0.35 4.62e-9 Bipolar disorder and schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26994227 chr5:130971071 RAPGEF6 -0.4 -6.11 -0.35 3.55e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12858900 chr10:24909511 ARHGAP21 -0.56 -6.47 -0.37 4.84e-10 Gut microbiome composition (summer); CESC cis rs17401966 0.838 rs7553228 chr1:10350438 G/C cg15208524 chr1:10270712 KIF1B 0.41 5.32 0.31 2.16e-7 Hepatocellular carcinoma; CESC trans rs1814175 0.587 rs7948538 chr11:50021353 A/C cg11707556 chr5:10655725 ANKRD33B -0.41 -6.01 -0.35 6.08e-9 Height; CESC cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg11812906 chr14:75593930 NEK9 -0.85 -13.81 -0.65 4.82e-33 Height; CESC cis rs7772486 0.754 rs702324 chr6:146008793 A/G cg05347473 chr6:146136440 FBXO30 -0.5 -6.27 -0.36 1.42e-9 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27656398 chr12:123451108 ABCB9 0.57 6.32 0.36 1.09e-9 Gut microbiome composition (summer); CESC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg18252515 chr7:66147081 NA 0.45 5.88 0.34 1.22e-8 Aortic root size; CESC cis rs6831352 0.959 rs4699710 chr4:100051819 C/T cg21548116 chr4:100009993 ADH5 0.48 5.15 0.3 4.98e-7 Alcohol dependence; CESC trans rs55704346 0.566 rs2292409 chr4:25394221 T/C cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs11764590 0.694 rs56072378 chr7:2104364 A/G cg21782813 chr7:2030301 MAD1L1 -0.41 -5.3 -0.31 2.42e-7 Neuroticism; CESC cis rs6540559 0.673 rs1073150 chr1:210017083 G/A cg22029157 chr1:209979665 IRF6 0.66 7.44 0.42 1.4e-12 Cleft lip with or without cleft palate; CESC cis rs208520 0.909 rs62414639 chr6:67023706 G/A cg07460842 chr6:66804631 NA 0.84 8.13 0.45 1.67e-14 Exhaled nitric oxide output; CESC cis rs6570726 0.934 rs9484995 chr6:145781114 T/A cg05347473 chr6:146136440 FBXO30 -0.4 -5.39 -0.31 1.54e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs12458462 0.787 rs56006341 chr18:77439844 G/T cg11879182 chr18:77439856 CTDP1 0.86 13.38 0.63 1.54e-31 Monocyte count; CESC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.45 7.31 0.41 3.08e-12 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11278799 chr20:13765577 ESF1;C20orf7 0.71 8.02 0.44 3.36e-14 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg23758822 chr17:41437982 NA 1.04 15.71 0.69 9.05e-40 Menopause (age at onset); CESC cis rs61869271 0.797 rs6585313 chr10:116745558 T/A cg23260525 chr10:116636907 FAM160B1 0.3 5.24 0.31 3.21e-7 Tonsillectomy; CESC cis rs10463316 0.894 rs6579860 chr5:150752338 G/A cg03212797 chr5:150827313 SLC36A1 -0.52 -6.83 -0.39 5.78e-11 Metabolite levels (Pyroglutamine); CESC cis rs72634258 0.945 rs12748993 chr1:8129507 A/G cg00042356 chr1:8021962 PARK7 0.83 7.94 0.44 5.61e-14 Inflammatory bowel disease; CESC cis rs2228479 0.850 rs57267516 chr16:89903552 G/A cg00800038 chr16:89945340 TCF25 -0.83 -6.72 -0.38 1.09e-10 Skin colour saturation; CESC cis rs4803468 0.934 rs11880674 chr19:41889423 A/T cg09537434 chr19:41945824 ATP5SL -1.01 -17.8 -0.74 3.78e-47 Height; CESC cis rs28386778 0.700 rs12449555 chr17:62003982 T/A cg06601766 chr17:61851465 DDX42;CCDC47 -0.55 -6.71 -0.38 1.21e-10 Prudent dietary pattern; CESC cis rs735860 0.726 rs209490 chr6:53179047 C/T cg10236188 chr6:53219634 NA 0.35 5.23 0.31 3.43e-7 Glaucoma; CESC cis rs9611565 0.694 rs9611591 chr22:41830212 G/A cg03806693 chr22:41940476 POLR3H 0.77 9.76 0.51 2.07e-19 Vitiligo; CESC trans rs9929218 0.817 rs3114405 chr16:68722377 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -9.91 -0.52 6.54e-20 Colorectal cancer; CESC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg25985355 chr7:65971099 NA 0.31 5.06 0.3 7.77e-7 Aortic root size; CESC cis rs1506636 0.927 rs6959270 chr7:123310628 G/A cg03229431 chr7:123269106 ASB15 -0.51 -6.63 -0.38 1.88e-10 Plateletcrit;Platelet count; CESC cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg03467027 chr4:99064603 C4orf37 0.43 5.42 0.32 1.34e-7 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg16325326 chr1:53192061 ZYG11B 0.9 14.66 0.67 4.89e-36 Monocyte count; CESC cis rs11722228 0.522 rs62286604 chr4:10131161 A/G cg14348967 chr4:10160060 NA -0.4 -5.1 -0.3 6.56e-7 Gout;Urate levels;Serum uric acid levels; CESC cis rs55788414 0.932 rs11649028 chr16:81185326 G/A cg06400318 chr16:81190750 PKD1L2 0.62 7.11 0.4 1.05e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs9348729 1 rs9348729 chr6:26664268 T/C cg12826209 chr6:26865740 GUSBL1 0.73 8.25 0.45 7.45e-15 Intelligence (multi-trait analysis); CESC cis rs9611565 0.765 rs132909 chr22:41802031 G/A cg06634786 chr22:41940651 POLR3H 0.71 7.47 0.42 1.16e-12 Vitiligo; CESC cis rs713587 0.967 rs10182181 chr2:25150296 C/T cg01884057 chr2:25150051 NA -0.43 -8.27 -0.45 6.53e-15 Body mass index in non-asthmatics; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11629460 chr3:141457364 RNF7 -0.46 -6.05 -0.35 4.96e-9 Asthma; CESC cis rs8067545 0.611 rs2526476 chr17:20134289 C/T cg13482628 chr17:19912719 NA -0.4 -5.33 -0.31 2.09e-7 Schizophrenia; CESC cis rs2486288 0.586 rs12909625 chr15:45572053 C/A cg21132104 chr15:45694354 SPATA5L1 -0.56 -6.7 -0.38 1.22e-10 Glomerular filtration rate; CESC cis rs2239815 0.515 rs5762829 chr22:29228130 A/G cg15103426 chr22:29168792 CCDC117 0.5 5.15 0.3 5.12e-7 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; CESC cis rs7264396 0.563 rs61191623 chr20:34219987 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.92 -10.16 -0.53 1.07e-20 Total cholesterol levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18264753 chr6:138188625 TNFAIP3 -0.48 -6.67 -0.38 1.5e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg23711669 chr6:146136114 FBXO30 1.02 15.62 0.69 2.01e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs2204008 0.846 rs2030416 chr12:38465118 A/G cg13010199 chr12:38710504 ALG10B -0.43 -5.6 -0.33 5.44e-8 Bladder cancer; CESC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg12963246 chr6:28129442 ZNF389 0.41 6.05 0.35 5e-9 Cardiac Troponin-T levels; CESC cis rs36051895 0.664 rs10116560 chr9:5096433 A/G cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.61e-9 Pediatric autoimmune diseases; CESC cis rs11690935 0.959 rs3770451 chr2:172668715 T/G cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.78 -0.67 1.79e-36 Schizophrenia; CESC cis rs453301 0.686 rs6601280 chr8:8909236 A/T cg15556689 chr8:8085844 FLJ10661 0.46 5.32 0.31 2.18e-7 Joint mobility (Beighton score); CESC cis rs9733 0.715 rs7534124 chr1:150739073 C/T cg13175981 chr1:150552382 MCL1 0.53 7.24 0.41 4.76e-12 Tonsillectomy; CESC cis rs4253772 0.591 rs6007726 chr22:46650858 A/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.18 0.45 1.16e-14 LDL cholesterol;Cholesterol, total; CESC cis rs959260 1.000 rs7211915 chr17:73379872 A/G cg20590849 chr17:73267439 MIF4GD -0.57 -6.73 -0.38 1.07e-10 Systemic lupus erythematosus; CESC cis rs8053891 0.756 rs35800852 chr16:72002105 G/T cg04254540 chr16:71951199 KIAA0174 -0.44 -5.35 -0.31 1.92e-7 Coronary artery disease; CESC cis rs7927771 0.542 rs6485775 chr11:47773518 A/G cg05585544 chr11:47624801 NA -0.32 -5.04 -0.3 8.46e-7 Subjective well-being; CESC trans rs116095464 1.000 rs28416084 chr5:217640 G/A cg00938859 chr5:1591904 SDHAP3 0.66 6.24 0.36 1.72e-9 Breast cancer; CESC cis rs6499255 1.000 rs12446201 chr16:69815586 T/C cg15192750 chr16:69999425 NA 0.43 5.35 0.31 1.9e-7 IgE levels; CESC cis rs2267137 0.720 rs2018515 chr22:29818854 C/T cg07256473 chr22:29710276 RASL10A 0.35 5.09 0.3 6.69e-7 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg00166722 chr3:10149974 C3orf24 0.55 7.17 0.4 7.56e-12 Alzheimer's disease; CESC cis rs703842 0.616 rs10783850 chr12:58229377 T/C cg00677455 chr12:58241039 CTDSP2 0.72 9.73 0.51 2.43e-19 Multiple sclerosis; CESC cis rs7508679 1.000 rs7508679 chr19:7222832 A/G cg00428638 chr19:7224713 INSR 0.49 7.77 0.43 1.7e-13 Hypothyroidism; CESC cis rs4523957 0.583 rs2641443 chr17:2036162 G/A cg16513277 chr17:2031491 SMG6 -0.78 -11.57 -0.58 2.42e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1728785 0.818 rs1645984 chr16:68628850 T/C cg02972257 chr16:68554789 NA -0.68 -7.33 -0.41 2.81e-12 Ulcerative colitis; CESC trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg06636001 chr8:8085503 FLJ10661 -0.51 -6.28 -0.36 1.39e-9 Neuroticism; CESC trans rs7582180 0.700 rs1437971 chr2:100986964 A/C cg15313226 chr2:191045668 C2orf88 0.63 6.37 0.36 8.31e-10 Intelligence (multi-trait analysis); CESC cis rs11167764 1.000 rs10057309 chr5:141479870 T/C cg08523384 chr5:141488047 NDFIP1 -0.36 -5.52 -0.32 8.16e-8 Crohn's disease; CESC cis rs637571 0.544 rs12361552 chr11:65701204 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.46 -6.51 -0.37 3.65e-10 Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06521774 chr1:38397588 INPP5B 0.58 6.09 0.35 3.95e-9 Gut microbiome composition (summer); CESC cis rs10754283 0.967 rs10801759 chr1:90113745 A/G cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg00033643 chr7:134001901 SLC35B4 0.42 5.47 0.32 1.04e-7 Mean platelet volume; CESC cis rs8077577 0.895 rs11078412 chr17:18100618 C/T cg16794390 chr17:18148240 FLII -0.44 -6.05 -0.35 4.94e-9 Obesity-related traits; CESC cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg19052272 chr2:3704530 ALLC -0.47 -5.73 -0.33 2.72e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.39 -0.37 7.55e-10 Ankle injury; CESC cis rs11098499 0.954 rs10008392 chr4:120318839 G/A cg09307838 chr4:120376055 NA 0.91 12.37 0.61 4.66e-28 Corneal astigmatism; CESC cis rs17125944 0.686 rs6572868 chr14:53325090 C/T cg00686598 chr14:53173677 PSMC6 -0.67 -5.71 -0.33 3.04e-8 Alzheimer's disease (late onset); CESC cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg15017067 chr4:17643749 FAM184B 0.41 6.0 0.35 6.62e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.07 0.3 7.36e-7 Menopause (age at onset); CESC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.69 -0.33 3.28e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg01860947 chr19:15442741 NA -0.51 -6.31 -0.36 1.17e-9 Asthma; CESC cis rs7267979 0.966 rs2500433 chr20:25296335 A/G cg08601574 chr20:25228251 PYGB -0.36 -5.13 -0.3 5.74e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs11098499 0.604 rs12642411 chr4:120580525 T/C cg09307838 chr4:120376055 NA 0.75 9.37 0.5 3.21e-18 Corneal astigmatism; CESC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg08470875 chr2:26401718 FAM59B -0.75 -7.79 -0.43 1.56e-13 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs2159583 chr4:17658838 T/C cg16339924 chr4:17578868 LAP3 0.55 6.93 0.39 3.15e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8099014 0.861 rs4940703 chr18:56115386 A/G cg19312305 chr18:56117016 MIR122 -0.26 -5.21 -0.3 3.83e-7 Platelet count; CESC cis rs7223966 1.000 rs7216798 chr17:61740963 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.6 -0.33 5.23e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg01579765 chr21:45077557 HSF2BP -0.56 -9.81 -0.52 1.43e-19 Mean corpuscular volume; CESC cis rs3026101 0.624 rs1058398 chr17:5288760 C/T cg25236894 chr17:5323110 RPAIN;NUP88 -0.41 -5.68 -0.33 3.46e-8 Body mass index; CESC cis rs3820068 0.705 rs4646087 chr1:15822404 A/G cg18192808 chr1:15853278 DNAJC16 0.47 5.66 0.33 3.93e-8 Systolic blood pressure; CESC cis rs12142240 0.698 rs12385697 chr1:46818898 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs941873 0.838 rs2233713 chr10:81107135 A/C cg08514558 chr10:81106712 PPIF 0.38 6.45 0.37 5.35e-10 Height; CESC cis rs7520050 0.966 rs785471 chr1:46518677 T/C cg03146154 chr1:46216737 IPP -0.43 -5.55 -0.32 6.97e-8 Red blood cell count;Reticulocyte count; CESC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg25405998 chr7:65216604 CCT6P1 0.44 5.18 0.3 4.3e-7 Aortic root size; CESC cis rs1215050 0.791 rs4699318 chr4:98664370 T/G cg05340658 chr4:99064831 C4orf37 -0.47 -6.04 -0.35 5.08e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs425277 1.000 rs262676 chr1:2078482 T/A cg16545954 chr1:2118288 C1orf86 0.33 5.6 0.33 5.35e-8 Height; CESC cis rs7246657 0.943 rs10413602 chr19:37891492 T/C cg23950597 chr19:37808831 NA -0.61 -6.19 -0.36 2.31e-9 Coronary artery calcification; CESC cis rs546131 0.928 rs552171 chr11:34830709 G/T cg06937548 chr11:34938143 PDHX;APIP 0.53 6.55 0.37 3.03e-10 Lung disease severity in cystic fibrosis; CESC cis rs6752107 1.000 rs10165561 chr2:234172915 G/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 6.71 0.38 1.19e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs4568518 0.530 rs4493811 chr7:17983369 C/G cg03009463 chr7:17980271 SNX13 0.39 5.09 0.3 6.75e-7 Measles; CESC trans rs997295 0.529 rs12592315 chr15:68040266 A/G cg26946276 chr13:31736202 HSPH1 0.48 6.1 0.35 3.73e-9 Motion sickness; CESC cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9300255 0.602 rs10846486 chr12:123709927 G/A cg05973401 chr12:123451056 ABCB9 0.5 5.68 0.33 3.48e-8 Neutrophil percentage of white cells; CESC cis rs4835473 0.932 rs62339581 chr4:144706325 C/T cg25736465 chr4:144833511 NA -0.33 -5.43 -0.32 1.28e-7 Immature fraction of reticulocytes; CESC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs12291225 0.545 rs11023187 chr11:14345559 T/G cg19336497 chr11:14380999 RRAS2 -0.45 -6.67 -0.38 1.48e-10 Sense of smell; CESC cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg00033643 chr7:134001901 SLC35B4 0.44 5.59 0.32 5.6e-8 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23255964 chr5:138862353 TMEM173 -0.56 -6.06 -0.35 4.71e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs929354 0.772 rs3802125 chr7:156970563 A/C cg05182265 chr7:156933206 UBE3C -0.49 -7.28 -0.41 3.85e-12 Body mass index; CESC cis rs644799 1.000 rs596277 chr11:95566886 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.46 0.37 4.92e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs754466 0.651 rs10824582 chr10:79603688 T/C cg17075019 chr10:79541650 NA -0.87 -13.75 -0.65 7.62e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9814567 1.000 rs9883753 chr3:134247231 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.82 -0.34 1.69e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4072980 0.545 rs10890285 chr1:38453576 A/C cg18451016 chr1:38461880 NA -0.41 -5.59 -0.32 5.75e-8 Coronary artery disease; CESC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg18876405 chr7:65276391 NA 0.5 5.89 0.34 1.16e-8 Aortic root size; CESC cis rs116095464 0.558 rs10057492 chr5:239503 T/C cg22857025 chr5:266934 NA -1.29 -18.85 -0.76 7.29e-51 Breast cancer; CESC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg04287289 chr16:89883240 FANCA -0.45 -5.55 -0.32 7e-8 Vitiligo; CESC cis rs2294693 0.685 rs67525613 chr6:41008956 G/T cg14418226 chr6:40996092 UNC5CL 0.49 5.34 0.31 2e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg21226059 chr5:178986404 RUFY1 0.39 5.52 0.32 8.22e-8 Lung cancer; CESC cis rs9393777 0.588 rs11967935 chr6:26560672 A/C cg12826209 chr6:26865740 GUSBL1 0.71 8.5 0.46 1.44e-15 Intelligence (multi-trait analysis); CESC cis rs4727027 0.933 rs12704062 chr7:148827865 G/A cg23158103 chr7:148848205 ZNF398 -0.41 -6.74 -0.38 9.65e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11039798 0.925 rs10769373 chr11:48531980 T/A cg15704280 chr7:45808275 SEPT13 0.71 6.6 0.38 2.28e-10 Axial length; CESC cis rs2404602 0.684 rs2047504 chr15:76883516 A/T cg23625390 chr15:77176239 SCAPER -0.45 -6.16 -0.35 2.67e-9 Blood metabolite levels; CESC cis rs1538970 0.816 rs11211123 chr1:45957609 G/A cg24296786 chr1:45957014 TESK2 -0.46 -5.15 -0.3 4.97e-7 Platelet count; CESC trans rs931812 0.895 rs4734493 chr8:101902169 C/T cg20993868 chr7:22813445 NA -0.57 -8.66 -0.47 4.66e-16 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.71 0.58 8.13e-26 Platelet count; CESC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg07677032 chr17:61819896 STRADA 0.44 5.81 0.34 1.81e-8 Prudent dietary pattern; CESC cis rs2439831 0.850 rs524417 chr15:43772374 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.82 11.53 0.58 3.28e-25 Lung cancer in ever smokers; CESC cis rs1707322 0.638 rs1416706 chr1:46602844 G/A cg06784218 chr1:46089804 CCDC17 -0.33 -5.25 -0.31 3.1e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg21784768 chr11:537496 LRRC56 -0.53 -5.17 -0.3 4.64e-7 Body mass index; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02836479 chr16:21964489 UQCRC2 -0.48 -6.55 -0.37 3.05e-10 Asthma; CESC cis rs9715521 0.900 rs6551646 chr4:59824827 A/G cg11281224 chr4:60001000 NA -0.51 -6.76 -0.38 8.63e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17095167 chr13:21833918 NA -0.45 -6.15 -0.35 2.92e-9 Gut microbiota (bacterial taxa); CESC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg08736216 chr1:53307985 ZYG11A -0.42 -6.95 -0.39 2.76e-11 Monocyte count; CESC cis rs2439831 0.867 rs2260160 chr15:43895643 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.66 8.55 0.47 9.65e-16 Lung cancer in ever smokers; CESC trans rs61931739 0.553 rs68124042 chr12:34064431 C/A cg26384229 chr12:38710491 ALG10B 0.6 8.38 0.46 3.12e-15 Morning vs. evening chronotype; CESC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg27170947 chr2:26402098 FAM59B 0.87 9.85 0.52 1.01e-19 Gut microbiome composition (summer); CESC cis rs533581 0.866 rs4995274 chr16:88970040 T/C cg16701003 chr16:89028210 CBFA2T3 0.46 6.78 0.38 7.91e-11 Social autistic-like traits; CESC cis rs909002 0.849 rs10753257 chr1:32086089 G/A cg13919466 chr1:32135498 COL16A1 -0.47 -8.36 -0.46 3.65e-15 Intelligence (multi-trait analysis); CESC cis rs9888739 0.800 rs7193268 chr16:31340997 A/G cg15817542 chr16:31343056 ITGAM 0.44 6.08 0.35 4.19e-9 Systemic lupus erythematosus; CESC cis rs16854884 1.000 rs16854886 chr3:143781492 A/G cg06585982 chr3:143692056 C3orf58 0.47 5.23 0.31 3.37e-7 Economic and political preferences (feminism/equality); CESC cis rs11711311 0.955 rs9830102 chr3:113408302 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.67 8.96 0.48 5.9e-17 IgG glycosylation; CESC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.84 -12.56 -0.61 1.1e-28 Prudent dietary pattern; CESC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.47 6.72 0.38 1.12e-10 Menopause (age at onset); CESC cis rs10779751 0.770 rs4845853 chr1:11243470 A/G cg08854313 chr1:11322531 MTOR 0.85 12.53 0.61 1.31e-28 Body mass index; CESC cis rs75804782 0.521 rs55690022 chr2:239407783 C/T cg18131467 chr2:239335373 ASB1 -0.71 -5.56 -0.32 6.45e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs472402 0.580 rs8192186 chr5:6652009 G/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.54 -7.04 -0.4 1.65e-11 Response to amphetamines; CESC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg24675658 chr1:53192096 ZYG11B -0.63 -8.54 -0.46 1.06e-15 Monocyte count; CESC cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg03467027 chr4:99064603 C4orf37 0.48 6.05 0.35 4.87e-9 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18388802 chr22:20004382 ARVCF -0.48 -6.12 -0.35 3.42e-9 Ulcerative colitis; CESC cis rs6542838 0.704 rs12474283 chr2:99527310 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.11 -0.3 6.12e-7 Fear of minor pain; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06684987 chr19:45567721 SFRS16 -0.63 -6.75 -0.38 9.08e-11 Gut microbiome composition (summer); CESC cis rs11078597 0.671 rs1310 chr17:1641715 G/T cg18436246 chr17:1640651 WDR81 0.62 7.59 0.42 5.36e-13 Serum albumin level; CESC cis rs2455799 0.533 rs924754 chr3:15756215 A/T cg09340198 chr3:15902540 ANKRD28 -0.33 -5.12 -0.3 6e-7 Mean platelet volume; CESC cis rs75804782 0.521 rs55713398 chr2:239419933 A/G cg18131467 chr2:239335373 ASB1 -0.68 -5.31 -0.31 2.36e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs5769765 1.000 rs8138941 chr22:50290678 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.14 -0.3 5.24e-7 Schizophrenia; CESC cis rs17376456 0.877 rs10078194 chr5:93364310 A/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.15 0.3 5.06e-7 Diabetic retinopathy; CESC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg11494091 chr17:61959527 GH2 0.72 12.33 0.6 6.37e-28 Prudent dietary pattern; CESC cis rs13256369 0.802 rs13256404 chr8:8562974 T/C cg17143192 chr8:8559678 CLDN23 0.78 8.81 0.48 1.63e-16 Obesity-related traits; CESC cis rs9291683 0.595 rs13145442 chr4:10037261 C/A cg02734326 chr4:10020555 SLC2A9 0.49 6.83 0.39 5.64e-11 Bone mineral density; CESC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg18538332 chr22:24372958 LOC391322 -0.62 -8.69 -0.47 3.73e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6701037 1.000 rs11585617 chr1:175123186 C/G cg00321850 chr1:175162397 KIAA0040 -0.42 -5.86 -0.34 1.37e-8 Alcohol dependence; CESC cis rs7264396 0.790 rs6121026 chr20:34266883 A/T cg23207816 chr20:34252616 CPNE1;RBM12 0.66 7.95 0.44 5.25e-14 Total cholesterol levels; CESC cis rs4843747 0.671 rs28671027 chr16:88116323 G/A cg03395651 chr16:88107091 BANP 0.45 5.2 0.3 4.07e-7 Menopause (age at onset); CESC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg18769074 chr3:133464867 TF 0.32 5.91 0.34 1.03e-8 Iron status biomarkers; CESC cis rs523522 0.926 rs10774555 chr12:120971978 G/A cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs938554 0.784 rs11722229 chr4:9980697 C/A cg11266682 chr4:10021025 SLC2A9 0.36 5.08 0.3 7.18e-7 Blood metabolite levels; CESC cis rs16858210 0.874 rs7618182 chr3:183607003 T/A cg25686905 chr3:183603175 PARL -0.34 -6.23 -0.36 1.84e-9 Menopause (age at onset); CESC cis rs992157 0.560 rs6436047 chr2:219108913 A/C cg00012203 chr2:219082015 ARPC2 0.79 10.82 0.55 7.71e-23 Colorectal cancer; CESC cis rs7385804 0.761 rs1734910 chr7:100309544 A/G cg16850897 chr7:100343110 ZAN 0.47 6.41 0.37 6.69e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC trans rs61931739 0.534 rs2636082 chr12:34061848 T/A cg26384229 chr12:38710491 ALG10B 0.53 7.25 0.41 4.63e-12 Morning vs. evening chronotype; CESC cis rs1927790 0.727 rs1925122 chr13:96938173 T/C cg02571835 chr13:96230311 CLDN10 -0.4 -5.75 -0.33 2.49e-8 Body mass index; CESC cis rs12681366 0.592 rs4735291 chr8:95407142 G/C cg13257157 chr8:95487014 RAD54B 0.43 5.1 0.3 6.52e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg18393722 chr15:85113863 UBE2QP1 -0.48 -6.55 -0.37 2.93e-10 Recombination measurement; CESC cis rs67478160 0.595 rs8022783 chr14:104245573 T/C cg08213375 chr14:104286397 PPP1R13B 0.55 11.0 0.56 2.01e-23 Schizophrenia; CESC cis rs6430585 0.528 rs309120 chr2:136708787 G/C cg07169764 chr2:136633963 MCM6 1.07 15.26 0.68 3.53e-38 Corneal structure; CESC cis rs6484504 0.576 rs11031323 chr11:31245413 T/G cg14844989 chr11:31128820 NA -0.43 -5.99 -0.35 6.7e-9 Red blood cell count; CESC cis rs2286503 0.966 rs2286507 chr7:22854760 T/C cg13679077 chr7:22862647 TOMM7 0.4 5.15 0.3 5.11e-7 Fibrinogen; CESC cis rs67311347 1.000 rs6801185 chr3:40505060 C/T cg24209194 chr3:40518798 ZNF619 -0.58 -7.88 -0.44 8.41e-14 Renal cell carcinoma; CESC cis rs11608355 0.545 rs61941585 chr12:109905222 C/T cg05360138 chr12:110035743 NA 0.79 8.25 0.45 7.43e-15 Neuroticism; CESC cis rs12410462 0.901 rs2814090 chr1:227658444 C/G cg23173402 chr1:227635558 NA -0.56 -5.75 -0.33 2.44e-8 Major depressive disorder; CESC cis rs4664304 1.000 rs55977890 chr2:160776866 C/T cg03641300 chr2:160917029 PLA2R1 -0.48 -6.9 -0.39 3.94e-11 Crohn's disease;Inflammatory bowel disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25152312 chr3:195595803 TNK2 0.47 6.62 0.38 2.03e-10 Fibrinogen levels; CESC cis rs1642645 0.831 rs1327711 chr1:42495949 A/G cg16685388 chr1:42384056 HIVEP3 0.38 5.71 0.33 3.07e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs9790314 0.934 rs455386 chr3:161102495 A/T cg03342759 chr3:160939853 NMD3 -0.46 -5.95 -0.34 8.51e-9 Morning vs. evening chronotype; CESC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 9.77 0.51 1.88e-19 Alzheimer's disease; CESC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg19774624 chr17:42201019 HDAC5 -0.82 -12.61 -0.61 7.15e-29 Total body bone mineral density; CESC cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg03806693 chr22:41940476 POLR3H 1.17 15.17 0.68 7.83e-38 Vitiligo; CESC cis rs10256972 0.527 rs28671326 chr7:1174973 G/A cg07308232 chr7:1071921 C7orf50 -0.41 -5.55 -0.32 7.03e-8 Longevity;Endometriosis; CESC cis rs62432291 0.681 rs400477 chr6:159635943 A/C cg14500486 chr6:159655392 FNDC1 0.55 6.11 0.35 3.62e-9 Joint mobility (Beighton score); CESC cis rs8005677 1.000 rs11157930 chr14:23403171 T/G cg01529538 chr14:23388837 RBM23 0.5 6.74 0.38 9.9e-11 Cognitive ability (multi-trait analysis); CESC cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg11890956 chr21:40555474 PSMG1 0.69 9.49 0.5 1.39e-18 Cognitive function; CESC cis rs5758659 1.000 rs134869 chr22:42652074 G/A cg04733989 chr22:42467013 NAGA 0.41 5.73 0.33 2.75e-8 Cognitive function; CESC cis rs1707322 0.716 rs6694889 chr1:46101806 A/C cg05343316 chr1:45956843 TESK2 0.51 6.35 0.36 9.44e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01704976 chr3:52273381 TWF2 -0.44 -6.28 -0.36 1.4e-9 Gut microbiota (bacterial taxa); CESC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg22800045 chr5:56110881 MAP3K1 0.81 10.13 0.53 1.33e-20 Initial pursuit acceleration; CESC cis rs2455799 0.593 rs13085352 chr3:15914845 T/C cg16303742 chr3:15540471 COLQ -0.37 -5.67 -0.33 3.7e-8 Mean platelet volume; CESC cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg22508957 chr16:3507546 NAT15 0.41 5.55 0.32 6.94e-8 Body mass index (adult); CESC cis rs473651 0.904 rs551859 chr2:239371836 T/C cg18131467 chr2:239335373 ASB1 0.98 18.99 0.76 2.46e-51 Multiple system atrophy; CESC cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2120019 1.000 rs12910644 chr15:75358388 A/G cg09165964 chr15:75287851 SCAMP5 -0.73 -8.47 -0.46 1.7e-15 Blood trace element (Zn levels); CESC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.75 0.33 2.4e-8 Menopause (age at onset); CESC cis rs4853012 1.000 rs2280643 chr2:74358286 T/C cg20891558 chr2:74357851 NA 0.81 11.18 0.57 5.16e-24 Gestational age at birth (maternal effect); CESC cis rs3820068 0.581 rs1547033 chr1:15918988 T/C cg16988262 chr1:15930761 NA 0.33 5.33 0.31 2.14e-7 Systolic blood pressure; CESC trans rs4771450 0.925 rs7333033 chr13:103978262 G/T cg08736516 chr4:109541802 LOC285456;RPL34 -0.5 -6.61 -0.38 2.15e-10 Uric acid levels; CESC cis rs8067545 0.750 rs9897246 chr17:19965702 T/G cg13482628 chr17:19912719 NA 0.38 5.07 0.3 7.57e-7 Schizophrenia; CESC cis rs2228479 0.850 rs2286393 chr16:89809548 C/A cg00800038 chr16:89945340 TCF25 -0.86 -7.31 -0.41 3.14e-12 Skin colour saturation; CESC cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg06028605 chr16:24865363 SLC5A11 0.4 5.95 0.34 8.65e-9 Intelligence (multi-trait analysis); CESC cis rs10754283 0.967 rs7546518 chr1:90109956 C/T cg21401794 chr1:90099060 LRRC8C 0.69 9.23 0.49 9.05e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6142102 0.625 rs4911137 chr20:32535463 C/T cg08999081 chr20:33150536 PIGU 0.34 5.13 0.3 5.49e-7 Skin pigmentation; CESC cis rs10876993 0.890 rs799575 chr12:58069107 A/G cg18357645 chr12:58087776 OS9 0.63 10.41 0.54 1.65e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg03033257 chr22:50311977 ALG12;CRELD2 0.52 5.25 0.31 3.11e-7 Schizophrenia; CESC cis rs7408868 1.000 rs6512018 chr19:15282138 T/C cg14696996 chr19:15285081 NOTCH3 1.11 11.78 0.59 4.93e-26 Pulse pressure; CESC cis rs62064224 0.748 rs72813015 chr17:30693331 T/C cg24550644 chr17:30846204 MYO1D -0.35 -5.04 -0.3 8.61e-7 Schizophrenia; CESC cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg05347473 chr6:146136440 FBXO30 0.57 7.25 0.41 4.6e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs73072330 1.000 rs17729010 chr3:47912703 A/G cg04507495 chr3:47563649 NA -1.01 -7.58 -0.42 5.89e-13 Stem cell growth factor beta levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11287903 chr10:115613834 DCLRE1A;NHLRC2 -0.46 -6.57 -0.37 2.66e-10 Gambling; CESC cis rs4077515 0.967 rs4567159 chr9:139277059 G/A cg14169450 chr9:139327907 INPP5E 0.39 5.59 0.32 5.6e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14903685 chr15:70391316 TLE3 0.64 7.3 0.41 3.44e-12 Gut microbiome composition (summer); CESC cis rs13064411 0.627 rs9825827 chr3:113182231 T/C cg18753928 chr3:113234510 CCDC52 -0.46 -5.49 -0.32 9.43e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs727505 0.607 rs17387591 chr7:124799471 A/G cg23710748 chr7:124431027 NA -0.36 -5.43 -0.32 1.3e-7 Lewy body disease; CESC cis rs6831352 0.840 rs35073321 chr4:100053276 G/A cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg17178900 chr1:205818956 PM20D1 0.77 11.75 0.59 6.14e-26 Menarche (age at onset); CESC cis rs8017423 1.000 rs59052550 chr14:90665098 C/T cg14092571 chr14:90743983 NA -0.55 -8.14 -0.45 1.56e-14 Mortality in heart failure; CESC cis rs1008375 1.000 rs1121091 chr4:17676386 A/C cg02297831 chr4:17616191 MED28 0.45 5.64 0.33 4.42e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2228479 1.000 rs117406136 chr16:89974605 C/T cg04013166 chr16:89971882 TCF25 0.76 6.46 0.37 4.89e-10 Skin colour saturation; CESC cis rs11229555 1.000 rs1938598 chr11:58413910 T/C cg15696309 chr11:58395628 NA -0.44 -5.69 -0.33 3.39e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC trans rs3780486 0.505 rs10758194 chr9:33157419 G/T cg04842962 chr6:43655489 MRPS18A 0.67 10.25 0.53 5.53e-21 IgG glycosylation; CESC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg19077165 chr18:44547161 KATNAL2 -0.62 -9.39 -0.5 2.78e-18 Personality dimensions; CESC cis rs11112613 0.713 rs17037317 chr12:105952058 T/C cg03607813 chr12:105948248 NA 0.59 7.41 0.41 1.75e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs1005277 0.529 rs1780125 chr10:38531376 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -5.68 -0.33 3.45e-8 Extrinsic epigenetic age acceleration; CESC trans rs875971 0.964 rs9691480 chr7:65944306 A/C cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs7927592 0.513 rs901823 chr11:68205578 T/C cg16797656 chr11:68205561 LRP5 0.64 10.07 0.53 2.04e-20 Total body bone mineral density; CESC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.18 0.3 4.32e-7 Menopause (age at onset); CESC cis rs12545109 0.800 rs1530218 chr8:57407864 C/G cg09654669 chr8:57350985 NA -0.56 -6.65 -0.38 1.67e-10 Obesity-related traits; CESC cis rs1461503 0.966 rs11218908 chr11:122841687 A/G cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs6088590 0.610 rs6120663 chr20:33081906 A/C cg08999081 chr20:33150536 PIGU -0.63 -10.72 -0.55 1.65e-22 Coronary artery disease; CESC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.68 6.55 0.37 2.95e-10 LDL cholesterol;Cholesterol, total; CESC cis rs8044868 0.530 rs2287998 chr16:72059269 C/T cg16558253 chr16:72132732 DHX38 0.36 5.51 0.32 8.52e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs6963495 0.818 rs73190155 chr7:105153535 T/A cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg21488398 chr2:70369791 NA -0.46 -6.18 -0.35 2.34e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.18 0.3 4.42e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6582630 0.572 rs1969363 chr12:38514872 A/G cg26384229 chr12:38710491 ALG10B 0.43 5.96 0.34 8e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs826838 1.000 rs826889 chr12:39101076 G/A cg26384229 chr12:38710491 ALG10B -0.62 -10.2 -0.53 7.78e-21 Heart rate; CESC trans rs9398803 0.897 rs9398804 chr6:126703390 T/A cg03991309 chr1:68237761 GNG12 -0.42 -6.45 -0.37 5.29e-10 Male-pattern baldness; CESC cis rs2243480 0.901 rs313808 chr7:65499873 T/G cg12463550 chr7:65579703 CRCP 0.73 5.95 0.34 8.4e-9 Diabetic kidney disease; CESC cis rs28374715 0.662 rs28827035 chr15:41492290 G/A cg18705301 chr15:41695430 NDUFAF1 -0.82 -10.47 -0.54 1.08e-21 Ulcerative colitis; CESC cis rs12348691 0.503 rs6478423 chr9:100592030 C/T cg13688889 chr9:100608707 NA -0.91 -13.31 -0.63 2.78e-31 Alopecia areata; CESC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg13866156 chr1:1669148 SLC35E2 -0.41 -5.7 -0.33 3.22e-8 Body mass index; CESC cis rs12477438 0.765 rs1054042 chr2:99614396 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -9.2 -0.49 1.14e-17 Chronic sinus infection; CESC cis rs8060686 0.623 rs12599178 chr16:68128104 A/G cg26727032 chr16:67993705 SLC12A4 -0.6 -8.83 -0.48 1.47e-16 HDL cholesterol;Metabolic syndrome; CESC cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg18016565 chr1:150552671 MCL1 -0.35 -5.83 -0.34 1.61e-8 Tonsillectomy; CESC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC trans rs11098499 0.955 rs1397608 chr4:120161744 A/G cg25214090 chr10:38739885 LOC399744 0.64 8.53 0.46 1.16e-15 Corneal astigmatism; CESC trans rs4950322 0.518 rs61838951 chr1:146587663 T/C cg04954894 chr8:38089920 DDHD2 -0.58 -6.11 -0.35 3.52e-9 Protein quantitative trait loci; CESC cis rs62432291 0.681 rs435521 chr6:159662638 C/T cg14500486 chr6:159655392 FNDC1 0.59 6.15 0.35 2.83e-9 Joint mobility (Beighton score); CESC cis rs7296418 0.961 rs1790094 chr12:123586688 T/C cg00376283 chr12:123451042 ABCB9 0.73 10.52 0.54 7.57e-22 Platelet count; CESC cis rs9399401 0.667 rs6903424 chr6:142699948 A/C cg04461802 chr6:142623433 GPR126 0.33 5.08 0.3 7.06e-7 Chronic obstructive pulmonary disease; CESC cis rs17384381 0.636 rs11161615 chr1:85906816 A/G cg16011679 chr1:85725395 C1orf52 -0.54 -5.7 -0.33 3.13e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1538970 0.669 rs3219476 chr1:45802670 A/C cg05343316 chr1:45956843 TESK2 -0.6 -8.32 -0.46 4.71e-15 Platelet count; CESC cis rs1879734 0.731 rs12405835 chr1:54129732 C/G cg23596471 chr1:54105337 GLIS1 0.35 5.3 0.31 2.49e-7 Mitral valve prolapse; CESC cis rs9467711 0.559 rs6920256 chr6:26537801 G/A cg12826209 chr6:26865740 GUSBL1 0.58 5.17 0.3 4.71e-7 Autism spectrum disorder or schizophrenia; CESC cis rs2243480 0.908 rs2460431 chr7:65622846 A/G cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.25e-32 Diabetic kidney disease; CESC cis rs7666738 0.830 rs34892904 chr4:98938097 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2760061 0.626 rs596208 chr1:228117982 G/C cg02753203 chr1:228287806 NA -0.5 -7.24 -0.41 4.83e-12 Diastolic blood pressure; CESC cis rs6964587 1.000 rs12540565 chr7:91633213 T/G cg17063962 chr7:91808500 NA 0.57 7.92 0.44 6.39e-14 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04246357 chr6:158589294 SERAC1;GTF2H5 -0.45 -6.19 -0.36 2.28e-9 Fibrinogen levels; CESC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.66 0.43 3.42e-13 Prudent dietary pattern; CESC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg22638593 chr5:131593259 PDLIM4 0.41 5.28 0.31 2.71e-7 Breast cancer; CESC cis rs2304069 0.779 rs245080 chr5:149354805 A/G cg12661370 chr5:149340060 SLC26A2 -0.44 -5.05 -0.3 8.43e-7 HIV-1 control; CESC cis rs4835473 0.932 rs11730929 chr4:144755948 C/T cg25736465 chr4:144833511 NA -0.45 -6.75 -0.38 9.22e-11 Immature fraction of reticulocytes; CESC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg27427491 chr17:78079615 GAA 0.34 5.53 0.32 7.54e-8 Yeast infection; CESC cis rs734999 0.588 rs6668149 chr1:2558308 A/C cg20673091 chr1:2541236 MMEL1 -0.47 -7.84 -0.43 1.11e-13 Ulcerative colitis; CESC cis rs780096 0.526 rs11682621 chr2:27749669 G/A cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.53 -0.32 7.81e-8 Total body bone mineral density; CESC cis rs6952809 0.532 rs6952152 chr7:2440912 G/A cg23289794 chr7:2394357 EIF3B -0.79 -7.29 -0.41 3.64e-12 Multiple sclerosis; CESC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg22963979 chr7:1858916 MAD1L1 -0.38 -5.31 -0.31 2.36e-7 Bipolar disorder and schizophrenia; CESC cis rs853679 0.545 rs35949109 chr6:28025926 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.87 6.98 0.39 2.41e-11 Depression; CESC cis rs4450798 0.649 rs6808603 chr3:13806359 T/C cg23332027 chr3:13681764 NA 0.41 5.47 0.32 1.04e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg00310523 chr12:86230176 RASSF9 -0.35 -5.55 -0.32 7.09e-8 Major depressive disorder; CESC cis rs17376456 0.877 rs9885329 chr5:93380278 G/A cg21475434 chr5:93447410 FAM172A 0.84 7.15 0.4 8.34e-12 Diabetic retinopathy; CESC cis rs1538970 1.000 rs4660853 chr1:45849090 C/T cg05343316 chr1:45956843 TESK2 0.84 11.94 0.59 1.41e-26 Platelet count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22728371 chr5:32313149 MTMR12 -0.4 -6.3 -0.36 1.21e-9 Gambling; CESC cis rs796364 0.806 rs34381014 chr2:200916403 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC cis rs6736093 0.901 rs34875611 chr2:112763025 G/A cg12686935 chr2:112915763 FBLN7 -0.43 -5.64 -0.33 4.33e-8 Coronary artery disease; CESC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg07507251 chr3:52567010 NT5DC2 0.33 5.64 0.33 4.31e-8 Electroencephalogram traits; CESC cis rs1609391 0.543 rs6800690 chr3:136623026 G/A cg15507776 chr3:136538369 TMEM22 0.82 11.97 0.59 1.08e-26 Neuroticism; CESC cis rs12824058 0.831 rs4759653 chr12:130812604 T/C cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs7617773 0.832 rs6775114 chr3:48182620 G/C cg11946769 chr3:48343235 NME6 -0.61 -8.18 -0.45 1.18e-14 Coronary artery disease; CESC cis rs7615952 0.673 rs9289270 chr3:125636979 A/T cg05084668 chr3:125655381 ALG1L -0.78 -7.65 -0.43 3.65e-13 Blood pressure (smoking interaction); CESC cis rs9937943 0.614 rs35148538 chr16:74613575 G/C cg01733217 chr16:74700730 RFWD3 0.61 5.2 0.3 4.04e-7 Neutrophil percentage of white cells; CESC cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.76 -12.55 -0.61 1.16e-28 Personality dimensions; CESC cis rs2380220 0.808 rs2716070 chr6:95912375 T/C cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.15 -0.3 5.05e-7 Breast cancer; CESC cis rs4664308 0.967 rs56293836 chr2:160910958 T/C cg03641300 chr2:160917029 PLA2R1 -0.68 -10.17 -0.53 9.82e-21 Idiopathic membranous nephropathy; CESC cis rs2302190 0.941 rs6503865 chr17:56549672 A/C cg25885038 chr17:56607967 SEPT4 -0.4 -5.41 -0.32 1.44e-7 Vitamin D levels; CESC cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg22875332 chr1:76189707 ACADM 0.48 5.56 0.32 6.45e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6987853 0.761 rs2974322 chr8:42424724 T/C cg09913449 chr8:42400586 C8orf40 0.46 7.79 0.43 1.53e-13 Mean corpuscular hemoglobin concentration; CESC cis rs35110281 0.627 rs7283362 chr21:44973667 C/G cg21573476 chr21:45109991 RRP1B -0.4 -5.5 -0.32 8.96e-8 Mean corpuscular volume; CESC cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.32 -5.54 -0.32 7.35e-8 Cystic fibrosis severity; CESC cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.38 0.61 4.42e-28 Colonoscopy-negative controls vs population controls; CESC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg10053473 chr17:62856997 LRRC37A3 -0.72 -7.56 -0.42 6.69e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg19468946 chr17:37922297 IKZF3 0.43 5.53 0.32 7.49e-8 Glomerular filtration rate (creatinine); CESC cis rs55794721 0.509 rs6699113 chr1:25777743 C/T cg02931644 chr1:25747376 RHCE 0.46 7.97 0.44 4.84e-14 Plateletcrit;Mean corpuscular volume; CESC cis rs6456156 0.586 rs6456149 chr6:167463902 T/C cg07741184 chr6:167504864 NA 0.35 6.1 0.35 3.81e-9 Primary biliary cholangitis; CESC cis rs703842 1.000 rs10877013 chr12:58165085 C/T cg00677455 chr12:58241039 CTDSP2 0.51 6.67 0.38 1.47e-10 Multiple sclerosis; CESC cis rs66686620 1.000 rs4401244 chr2:69247005 A/G cg12800200 chr2:69260302 ANTXR1 -0.4 -5.89 -0.34 1.15e-8 Breast cancer; CESC cis rs2439831 0.541 rs12440854 chr15:43610672 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.74 6.24 0.36 1.77e-9 Lung cancer in ever smokers; CESC cis rs698833 0.548 rs1372079 chr2:44543317 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.54 5.51 0.32 8.32e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs453301 0.571 rs2929454 chr8:9083854 A/C cg17143192 chr8:8559678 CLDN23 -0.47 -5.66 -0.33 3.89e-8 Joint mobility (Beighton score); CESC cis rs708547 0.647 rs1403233 chr4:57885053 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.49 -6.74 -0.38 9.89e-11 Response to bleomycin (chromatid breaks); CESC cis rs3780486 0.846 rs4584234 chr9:33147479 G/A cg13443165 chr9:33130375 B4GALT1 0.45 6.54 0.37 3.08e-10 IgG glycosylation; CESC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.82 -9.22 -0.49 9.78e-18 Gut microbiome composition (summer); CESC cis rs965469 0.895 rs12626130 chr20:3393192 G/T cg25506879 chr20:3388711 C20orf194 -0.63 -6.42 -0.37 6.37e-10 IFN-related cytopenia; CESC trans rs61931739 0.500 rs11053213 chr12:34466395 G/T cg26384229 chr12:38710491 ALG10B 0.71 10.64 0.55 3.04e-22 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04719816 chr4:529996 PIGG 0.5 6.48 0.37 4.51e-10 Fibrinogen levels; CESC cis rs533581 0.866 rs871756 chr16:88969076 G/C cg16701003 chr16:89028210 CBFA2T3 0.46 6.3 0.36 1.23e-9 Social autistic-like traits; CESC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg14926445 chr8:58193284 C8orf71 -0.5 -5.45 -0.32 1.18e-7 Developmental language disorder (linguistic errors); CESC cis rs16986825 0.570 rs5752822 chr22:29266025 A/G cg15103426 chr22:29168792 CCDC117 0.48 5.12 0.3 5.8e-7 Pancreatic cancer; CESC cis rs9929218 1.000 rs12446407 chr16:68804068 G/A cg02972257 chr16:68554789 NA 0.43 5.18 0.3 4.44e-7 Colorectal cancer; CESC cis rs4481887 0.962 rs10788768 chr1:248456027 G/A cg00666640 chr1:248458726 OR2T12 0.4 6.62 0.38 1.97e-10 Common traits (Other); CESC cis rs911555 0.692 rs7146215 chr14:103915908 A/G cg12935359 chr14:103987150 CKB 0.66 9.78 0.52 1.71e-19 Intelligence (multi-trait analysis); CESC cis rs11997175 0.935 rs3903385 chr8:33687399 T/G ch.8.33884649F chr8:33765107 NA 0.62 7.75 0.43 1.98e-13 Body mass index; CESC cis rs9768139 0.708 rs10233815 chr7:158114348 C/T cg06219351 chr7:158114137 PTPRN2 -0.56 -8.96 -0.48 5.77e-17 Calcium levels; CESC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg10578991 chr7:12443926 VWDE -0.45 -5.09 -0.3 6.83e-7 Coronary artery disease; CESC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg04511125 chr2:88470314 THNSL2 -0.52 -7.7 -0.43 2.76e-13 Response to metformin (IC50); CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg05564831 chr3:52568323 NT5DC2 -0.49 -8.21 -0.45 9.82e-15 Electroencephalogram traits; CESC cis rs208520 0.690 rs12213575 chr6:66735989 A/G cg07460842 chr6:66804631 NA 0.96 12.81 0.62 1.47e-29 Exhaled nitric oxide output; CESC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg05313129 chr8:58192883 C8orf71 -0.49 -5.33 -0.31 2.07e-7 Developmental language disorder (linguistic errors); CESC trans rs9467711 0.606 rs12176317 chr6:26372786 A/G cg06606381 chr12:133084897 FBRSL1 -0.76 -6.89 -0.39 4.1e-11 Autism spectrum disorder or schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23418198 chr17:4925746 KIF1C 0.41 6.24 0.36 1.68e-9 Fibrinogen levels; CESC cis rs17826219 0.568 rs9907834 chr17:29154013 G/A cg13385521 chr17:29058706 SUZ12P 0.75 6.0 0.35 6.29e-9 Body mass index; CESC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg13206674 chr6:150067644 NUP43 0.41 5.91 0.34 1.04e-8 Lung cancer; CESC cis rs7000551 0.751 rs2449348 chr8:22359572 C/T cg12081754 chr8:22256438 SLC39A14 0.41 5.5 0.32 8.87e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.78 10.11 0.53 1.56e-20 Height; CESC trans rs2727020 0.553 rs7479975 chr11:49581964 C/G cg03929089 chr4:120376271 NA -0.78 -11.52 -0.58 3.71e-25 Coronary artery disease; CESC cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 11.25 0.57 2.87e-24 Hip circumference adjusted for BMI; CESC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg11764359 chr7:65958608 NA -0.8 -11.97 -0.59 1.1e-26 Aortic root size; CESC trans rs9325144 0.650 rs6582624 chr12:38733475 A/T cg23762105 chr12:34175262 ALG10 0.49 6.32 0.36 1.1e-9 Morning vs. evening chronotype; CESC cis rs7208859 0.673 rs2269916 chr17:29233763 A/G cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg02576092 chr1:27668556 SYTL1 0.45 6.23 0.36 1.8e-9 Weight; CESC cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg04455712 chr21:45112962 RRP1B 0.4 5.98 0.34 7.35e-9 Mean corpuscular volume; CESC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg21144161 chr5:423903 AHRR 0.37 6.03 0.35 5.59e-9 Cystic fibrosis severity; CESC trans rs9307551 0.817 rs6852514 chr4:80501913 C/T cg02747103 chr19:603718 HCN2 -0.41 -6.04 -0.35 5.25e-9 Refractive error; CESC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.05 0.4 1.55e-11 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16209303 chr14:103405847 CDC42BPB 0.45 6.74 0.38 9.93e-11 Fibrinogen levels; CESC cis rs4780401 0.539 rs62040604 chr16:11803641 G/A cg01061890 chr16:11836724 TXNDC11 -0.58 -7.95 -0.44 5.26e-14 Rheumatoid arthritis; CESC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg05064044 chr6:292385 DUSP22 -0.68 -8.67 -0.47 4.36e-16 Menopause (age at onset); CESC cis rs2294693 0.945 rs9381023 chr6:40983281 C/T cg14418226 chr6:40996092 UNC5CL -0.49 -5.78 -0.33 2.07e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.74 -9.05 -0.49 3.24e-17 Body mass index (adult); CESC cis rs34734847 0.965 rs2005455 chr12:121128699 A/G cg21892295 chr12:121157589 UNC119B -0.36 -5.81 -0.34 1.75e-8 Mean corpuscular volume; CESC cis rs1799949 0.864 rs60309406 chr17:41435665 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.08 0.3 7.12e-7 Menopause (age at onset); CESC trans rs274437 0.640 rs62420186 chr6:104819534 G/A cg04677410 chr11:95846117 MAML2 -0.52 -6.03 -0.35 5.36e-9 Colonoscopy-negative controls vs population controls; CESC cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg08847533 chr14:75593920 NEK9 0.9 15.67 0.69 1.24e-39 Height; CESC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.46 0.32 1.12e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs2727020 0.576 rs1814175 chr11:49559172 T/C cg03929089 chr4:120376271 NA -0.81 -12.23 -0.6 1.44e-27 Coronary artery disease; CESC cis rs6696846 0.630 rs6692706 chr1:205158561 G/T cg00857998 chr1:205179979 DSTYK 0.56 7.05 0.4 1.53e-11 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10219037 chr11:111750118 C11orf1;FDXACB1 -0.53 -6.12 -0.35 3.44e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00390337 chr16:1798633 MAPK8IP3 0.45 6.26 0.36 1.5e-9 Fibrinogen levels; CESC trans rs73206853 0.841 rs16940885 chr12:110971666 A/G cg22801913 chr11:47176841 C11orf49 0.5 6.07 0.35 4.47e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs4957048 0.577 rs56294732 chr5:568144 T/C cg16447950 chr5:562315 NA -0.66 -7.73 -0.43 2.18e-13 Ulcerative colitis; CESC cis rs11139399 0.650 rs6559638 chr9:84349669 T/A cg07852945 chr9:84303915 TLE1 0.37 5.61 0.33 5.15e-8 Hippocampal atrophy; CESC cis rs35110281 0.627 rs6518268 chr21:44967448 A/G cg04455712 chr21:45112962 RRP1B 0.35 5.22 0.31 3.61e-7 Mean corpuscular volume; CESC cis rs926938 0.563 rs360655 chr1:115447867 T/C cg12756093 chr1:115239321 AMPD1 0.48 6.94 0.39 3e-11 Autism; CESC cis rs2439831 0.681 rs7168940 chr15:43633334 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.67 0.55 2.46e-22 Lung cancer in ever smokers; CESC cis rs7824557 0.767 rs17797443 chr8:11164012 T/C cg21775007 chr8:11205619 TDH 0.48 7.0 0.39 2.13e-11 Retinal vascular caliber; CESC cis rs8062405 1.000 rs56404918 chr16:28846840 T/G cg08761264 chr16:28874980 SH2B1 -0.46 -5.77 -0.33 2.26e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9549260 0.816 rs7334318 chr13:41217410 C/G cg21288729 chr13:41239152 FOXO1 0.68 8.81 0.48 1.67e-16 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02364793 chr5:175964512 RNF44 -0.66 -8.0 -0.44 3.9e-14 Gut microbiome composition (summer); CESC cis rs7617480 0.648 rs9859473 chr3:48837182 A/G cg07636037 chr3:49044803 WDR6 0.79 10.64 0.55 2.92e-22 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs36051895 0.659 rs4495487 chr9:5072798 T/C cg02405213 chr9:5042618 JAK2 -0.51 -6.19 -0.36 2.28e-9 Pediatric autoimmune diseases; CESC cis rs6714710 0.603 rs956039 chr2:98416848 C/A cg26665480 chr2:98280029 ACTR1B 0.68 9.4 0.5 2.59e-18 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs11577318 0.853 rs2276712 chr1:26627478 T/C cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.45 -0.37 5.21e-10 Granulocyte percentage of myeloid white cells; CESC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg17376030 chr22:41985996 PMM1 0.76 8.18 0.45 1.22e-14 Vitiligo; CESC cis rs7937682 0.889 rs497111 chr11:111499512 G/A cg22437258 chr11:111473054 SIK2 0.7 9.18 0.49 1.31e-17 Primary sclerosing cholangitis; CESC cis rs9303401 0.614 rs12948536 chr17:56580413 G/T cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.43 0.61 2.87e-28 Cognitive test performance; CESC cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg10556349 chr10:835070 NA 0.53 5.24 0.31 3.21e-7 Eosinophil percentage of granulocytes; CESC cis rs4979906 1.000 rs12264636 chr10:79448539 C/G cg00983440 chr10:79422392 NA 0.5 5.34 0.31 1.99e-7 Mortality in heart failure; CESC cis rs5753037 0.543 rs140126 chr22:30147038 A/G cg01021169 chr22:30184971 ASCC2 -0.55 -7.83 -0.43 1.17e-13 Type 1 diabetes; CESC cis rs1983170 1.000 rs1983170 chr1:91986482 G/A cg21854759 chr1:92012499 NA 0.51 5.54 0.32 7.25e-8 Eosinophil percentage of white cells; CESC cis rs561341 1.000 rs548957 chr17:30302411 G/A cg12193833 chr17:30244370 NA -0.7 -6.49 -0.37 4.19e-10 Hip circumference adjusted for BMI; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg10647644 chr5:118788352 HSD17B4 0.45 6.02 0.35 5.7e-9 Thyroid stimulating hormone; CESC cis rs11098499 0.954 rs13107475 chr4:120393011 A/T cg09307838 chr4:120376055 NA 0.95 14.11 0.66 4.2e-34 Corneal astigmatism; CESC cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.94e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25330243 chr8:102504501 GRHL2 0.56 6.42 0.37 6.12e-10 Gut microbiome composition (summer); CESC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg25767906 chr1:53392781 SCP2 -0.49 -6.26 -0.36 1.55e-9 Monocyte count; CESC cis rs2439831 0.702 rs7171750 chr15:44025858 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 8.06 0.44 2.56e-14 Lung cancer in ever smokers; CESC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg08859206 chr1:53392774 SCP2 -0.52 -6.8 -0.39 6.9e-11 Monocyte count; CESC cis rs244293 0.760 rs12945393 chr17:53045243 G/A cg19360675 chr17:53046073 COX11;STXBP4 -0.45 -6.26 -0.36 1.58e-9 Menarche (age at onset); CESC cis rs7927771 0.839 rs7124681 chr11:47529947 C/A cg18512352 chr11:47633146 NA -0.46 -7.15 -0.4 8.38e-12 Subjective well-being; CESC cis rs2425143 0.558 rs7274724 chr20:34539466 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.1 -0.4 1.13e-11 Blood protein levels; CESC cis rs2758596 0.850 rs2495270 chr1:156181530 A/G cg25208724 chr1:156163844 SLC25A44 0.66 6.15 0.35 2.87e-9 Paclitaxel disposition in epithelial ovarian cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24488506 chr11:65667952 FOSL1 -0.46 -6.06 -0.35 4.73e-9 Ulcerative colitis; CESC cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg04455712 chr21:45112962 RRP1B 0.39 5.69 0.33 3.31e-8 Mean corpuscular volume; CESC cis rs10479542 0.503 rs12719865 chr5:178993566 C/T cg22764044 chr5:178986830 RUFY1 0.46 6.66 0.38 1.55e-10 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26464524 chr7:99699573 MCM7;AP4M1 0.57 6.48 0.37 4.43e-10 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13451483 chr19:5720795 TMEM146;LONP1 -0.46 -6.48 -0.37 4.47e-10 Gut microbiota (bacterial taxa); CESC cis rs7188697 0.922 rs37056 chr16:58560877 G/A cg21335942 chr16:58549945 SETD6 0.46 5.41 0.32 1.4e-7 QT interval; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25308054 chr19:10676770 KRI1 -0.41 -6.18 -0.35 2.39e-9 Gambling; CESC cis rs9399401 0.601 rs262113 chr6:142824950 T/G cg03128060 chr6:142623767 GPR126 0.33 5.32 0.31 2.22e-7 Chronic obstructive pulmonary disease; CESC cis rs1707322 0.627 rs3014213 chr1:46045522 T/C cg03146154 chr1:46216737 IPP -0.77 -10.4 -0.54 1.77e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.33 5.29 0.31 2.54e-7 Monocyte percentage of white cells; CESC cis rs3733585 0.753 rs12500805 chr4:10017979 C/T cg00071950 chr4:10020882 SLC2A9 0.87 15.65 0.69 1.54e-39 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8005677 0.828 rs4981450 chr14:23389304 A/G cg25600027 chr14:23388339 RBM23 -0.41 -5.06 -0.3 8.03e-7 Cognitive ability (multi-trait analysis); CESC cis rs10949834 0.590 rs1091815 chr7:73489643 G/A cg07137043 chr7:73588983 EIF4H 0.58 6.53 0.37 3.37e-10 Verbal memory performance (residualized delayed recall change); CESC cis rs6502050 0.835 rs4499294 chr17:80148346 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.56e-7 Life satisfaction; CESC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg18876405 chr7:65276391 NA 0.58 8.07 0.44 2.51e-14 Aortic root size; CESC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg16049864 chr8:95962084 TP53INP1 -0.67 -12.13 -0.6 3.13e-27 Type 2 diabetes; CESC cis rs6991838 0.584 rs13268343 chr8:66543977 C/T cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs7020830 0.931 rs7851239 chr9:37138672 A/G cg14294708 chr9:37120828 ZCCHC7 -1.15 -18.46 -0.75 1.71e-49 Schizophrenia; CESC cis rs2243480 1.000 rs35432774 chr7:65393019 G/C cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.48 6.79 0.39 7.21e-11 Menopause (age at onset); CESC cis rs9640161 0.750 rs11538922 chr7:150035183 C/T cg21361702 chr7:150065534 REPIN1 0.55 5.9 0.34 1.11e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs523522 0.962 rs3759394 chr12:120933173 C/A cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs2486288 0.656 rs12440356 chr15:45567529 T/C cg21132104 chr15:45694354 SPATA5L1 0.62 7.26 0.41 4.26e-12 Glomerular filtration rate; CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg22907277 chr7:1156413 C7orf50 0.42 5.94 0.34 9.06e-9 Longevity;Endometriosis; CESC cis rs10870270 0.956 rs6557 chr10:133781449 C/T cg26149184 chr10:133730230 NA 0.38 5.14 0.3 5.32e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg13393036 chr8:95962371 TP53INP1 -0.52 -11.34 -0.57 1.43e-24 Type 2 diabetes; CESC trans rs11039798 0.588 rs6485869 chr11:48576903 G/T cg15704280 chr7:45808275 SEPT13 0.64 6.64 0.38 1.78e-10 Axial length; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16798694 chr8:141557712 EIF2C2 0.51 6.61 0.38 2.12e-10 Fibrinogen levels; CESC cis rs9300255 0.544 rs1790100 chr12:123656725 G/T cg05973401 chr12:123451056 ABCB9 0.5 5.7 0.33 3.19e-8 Neutrophil percentage of white cells; CESC cis rs2280018 0.526 rs1510148 chr16:15167379 T/A cg07549590 chr16:15018862 NA -0.61 -9.76 -0.51 2.07e-19 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs10871290 0.730 rs6564097 chr16:74466419 T/C cg01733217 chr16:74700730 RFWD3 -0.69 -9.24 -0.49 8.21e-18 Breast cancer; CESC cis rs7044106 0.734 rs1981020 chr9:123388464 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.84 0.34 1.54e-8 Hip circumference adjusted for BMI; CESC cis rs17209837 0.564 rs117373803 chr7:87096783 A/G cg00919237 chr7:87102261 ABCB4 -0.49 -6.39 -0.37 7.37e-10 Gallbladder cancer; CESC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.78 0.47 2.04e-16 Bipolar disorder; CESC cis rs765787 0.530 rs4775819 chr15:45525966 C/T cg24006582 chr15:45444508 DUOX1 -0.6 -7.35 -0.41 2.45e-12 Uric acid levels; CESC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg24060327 chr5:131705240 SLC22A5 -0.71 -9.86 -0.52 1e-19 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24714709 chr7:95064397 PON2 0.61 7.25 0.41 4.71e-12 Gut microbiome composition (summer); CESC cis rs6570726 0.875 rs373313 chr6:145857791 T/C cg23711669 chr6:146136114 FBXO30 0.8 11.74 0.58 6.58e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs12900413 0.603 rs2882677 chr15:90299514 C/T cg24249390 chr15:90295951 MESP1 -0.4 -5.46 -0.32 1.08e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs10927875 0.722 rs6660685 chr1:16346988 A/G cg21214613 chr1:16344536 HSPB7 0.36 5.17 0.3 4.51e-7 Dilated cardiomyopathy; CESC cis rs11997175 0.574 rs58858314 chr8:33658221 T/C ch.8.33884649F chr8:33765107 NA 0.67 8.5 0.46 1.38e-15 Body mass index; CESC cis rs6964587 0.967 rs6465341 chr7:91596121 G/C cg17063962 chr7:91808500 NA 0.58 7.91 0.44 6.94e-14 Breast cancer; CESC cis rs34891900 0.507 rs1008378 chr22:18207251 T/C cg19898043 chr22:18121309 BCL2L13 0.58 6.57 0.37 2.6e-10 Sum neutrophil eosinophil counts; CESC cis rs546131 0.928 rs516228 chr11:34838823 C/T cg11058730 chr11:34937778 PDHX;APIP 0.5 6.5 0.37 3.96e-10 Lung disease severity in cystic fibrosis; CESC cis rs2050392 0.965 rs2265370 chr10:30690581 C/T cg18806716 chr10:30721971 MAP3K8 -0.4 -5.62 -0.33 4.93e-8 Inflammatory bowel disease; CESC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg08632164 chr7:65971372 NA 0.32 5.11 0.3 6.05e-7 Aortic root size; CESC cis rs10851478 0.558 rs17478694 chr15:49738542 C/G cg08060515 chr15:49448048 GALK2;COPS2 0.5 6.25 0.36 1.61e-9 Oral cavity cancer; CESC cis rs36051895 0.659 rs62541538 chr9:5038164 G/A cg02405213 chr9:5042618 JAK2 -0.47 -5.66 -0.33 3.99e-8 Pediatric autoimmune diseases; CESC cis rs2635047 0.875 rs2251948 chr18:44681356 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.8 0.39 7.02e-11 Educational attainment; CESC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg10691866 chr7:65817282 TPST1 0.33 5.59 0.32 5.54e-8 Aortic root size; CESC cis rs6543140 0.929 rs7602207 chr2:103032366 C/G cg04239558 chr2:103089729 SLC9A4 0.45 5.76 0.33 2.28e-8 Blood protein levels; CESC cis rs3793683 0.545 rs12784446 chr10:134589094 T/G cg18305652 chr10:134549665 INPP5A 0.5 7.2 0.4 6.38e-12 Migraine; CESC cis rs2046867 0.818 rs17010195 chr3:72872852 A/G cg25664220 chr3:72788482 NA 0.38 5.66 0.33 3.86e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13662628 chr9:127572244 OLFML2A 0.42 6.07 0.35 4.44e-9 Fibrinogen levels; CESC cis rs2204008 0.668 rs1619009 chr12:38120485 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.92 -0.34 9.92e-9 Bladder cancer; CESC cis rs6831352 0.918 rs13138294 chr4:100062675 T/G cg13256891 chr4:100009986 ADH5 -0.76 -8.4 -0.46 2.83e-15 Alcohol dependence; CESC trans rs17764205 0.929 rs10420340 chr19:3256494 G/A cg27384338 chr17:2031545 SMG6 -0.64 -6.08 -0.35 4.2e-9 Bipolar disorder and schizophrenia; CESC cis rs9388451 0.626 rs1935983 chr6:126068914 C/T cg05901451 chr6:126070800 HEY2 -0.61 -9.27 -0.49 6.65e-18 Brugada syndrome; CESC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg04166393 chr7:2884313 GNA12 0.62 8.32 0.46 4.69e-15 Height; CESC cis rs501120 0.925 rs494045 chr10:44773498 C/T cg09554077 chr10:44749378 NA 0.48 5.05 0.3 8.15e-7 Coronary artery disease;Coronary heart disease; CESC cis rs12477438 0.520 rs7604557 chr2:99747829 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.04 0.68 2.28e-37 Chronic sinus infection; CESC cis rs4727027 0.933 rs757738 chr7:148872351 T/G cg23583168 chr7:148888333 NA -0.81 -12.5 -0.61 1.67e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs8077577 0.895 rs16960980 chr17:18100858 C/T cg16794390 chr17:18148240 FLII 0.45 6.26 0.36 1.57e-9 Obesity-related traits; CESC cis rs17666538 0.636 rs10107345 chr8:603700 G/T cg02524346 chr8:600233 NA 0.74 6.16 0.35 2.68e-9 IgG glycosylation; CESC cis rs6968419 0.755 rs17138486 chr7:115894403 C/G cg02561103 chr7:115862891 TES -0.4 -5.26 -0.31 2.92e-7 Intraocular pressure; CESC cis rs854765 0.583 rs11078406 chr17:17840823 G/T cg16928487 chr17:17741425 SREBF1 -0.52 -8.83 -0.48 1.51e-16 Total body bone mineral density; CESC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg05863683 chr7:1912471 MAD1L1 0.42 6.27 0.36 1.45e-9 Bipolar disorder and schizophrenia; CESC trans rs1977584 0.725 rs79498729 chr10:45402161 C/T cg09262100 chr14:103416268 CDC42BPB 0.61 6.14 0.35 3.02e-9 Selective IgA deficiency; CESC cis rs6912958 0.781 rs6454632 chr6:88231824 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.51 -6.77 -0.38 8.38e-11 Monocyte percentage of white cells; CESC cis rs6964587 1.000 rs56072181 chr7:91690457 A/G cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.45e-15 Breast cancer; CESC cis rs2228479 1.000 rs117406136 chr16:89974605 C/T cg14709524 chr16:89940631 TCF25 0.86 6.3 0.36 1.24e-9 Skin colour saturation; CESC cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg18225595 chr11:63971243 STIP1 0.62 8.65 0.47 4.96e-16 Platelet count; CESC cis rs1375194 0.606 rs17657783 chr2:33814590 A/G cg04131969 chr2:33951647 MYADML -0.5 -6.34 -0.36 9.94e-10 Response to antidepressants in depression; CESC cis rs7605827 0.930 rs10201925 chr2:15528742 G/A cg19274914 chr2:15703543 NA 0.36 6.35 0.36 9.19e-10 Educational attainment (years of education); CESC cis rs4900538 0.821 rs2009575 chr14:102820787 C/T cg18135206 chr14:102964638 TECPR2 -0.64 -7.68 -0.43 3.18e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs6964587 0.869 rs10250641 chr7:91490746 C/T cg17063962 chr7:91808500 NA 0.54 7.08 0.4 1.27e-11 Breast cancer; CESC cis rs459571 0.959 rs410876 chr9:136893867 C/A cg13789015 chr9:136890014 NCRNA00094 0.54 7.67 0.43 3.2e-13 Platelet distribution width; CESC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg07507251 chr3:52567010 NT5DC2 0.35 5.94 0.34 8.88e-9 Bipolar disorder; CESC cis rs62064224 0.589 rs9910731 chr17:30784034 A/G cg18200150 chr17:30822561 MYO1D 0.39 5.07 0.3 7.45e-7 Schizophrenia; CESC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg25036284 chr2:26402008 FAM59B 0.53 6.07 0.35 4.38e-9 Gut microbiome composition (summer); CESC cis rs76419734 0.510 rs4699198 chr4:106645771 G/A cg24545054 chr4:106630052 GSTCD;INTS12 0.7 8.65 0.47 4.92e-16 Post bronchodilator FEV1; CESC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg23758822 chr17:41437982 NA 1.03 15.15 0.68 8.71e-38 Menopause (age at onset); CESC cis rs9325144 0.555 rs4550281 chr12:38689937 A/G cg26384229 chr12:38710491 ALG10B 0.58 8.36 0.46 3.71e-15 Morning vs. evening chronotype; CESC trans rs6818288 0.778 rs12503551 chr4:30077431 G/A cg12528397 chr3:62933670 NA 0.42 6.13 0.35 3.2e-9 Obesity-related traits; CESC cis rs2304069 0.954 rs6579767 chr5:149406271 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.91 11.76 0.59 5.85e-26 HIV-1 control; CESC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg22433210 chr17:43662623 NA -0.6 -7.88 -0.44 8.39e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs911555 0.755 rs10144051 chr14:103885931 A/C cg12935359 chr14:103987150 CKB -0.56 -8.0 -0.44 3.82e-14 Intelligence (multi-trait analysis); CESC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg13607699 chr17:42295918 UBTF -0.59 -7.75 -0.43 1.99e-13 Total body bone mineral density; CESC cis rs11608355 0.508 rs12817730 chr12:109799330 G/A cg19025524 chr12:109796872 NA -0.42 -5.28 -0.31 2.63e-7 Neuroticism; CESC cis rs6546550 0.901 rs6546558 chr2:70145717 C/T cg02498382 chr2:70120550 SNRNP27 -0.43 -7.41 -0.41 1.65e-12 Prevalent atrial fibrillation; CESC cis rs12142240 0.698 rs6659228 chr1:46811027 C/G cg10495392 chr1:46806563 NSUN4 0.57 6.29 0.36 1.31e-9 Menopause (age at onset); CESC cis rs7631605 0.875 rs55898028 chr3:37248337 A/G cg22985146 chr3:37219077 LRRFIP2 -0.35 -5.64 -0.33 4.33e-8 Cerebrospinal P-tau181p levels; CESC trans rs1814175 0.645 rs11040702 chr11:50024827 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -18.54 -0.75 9.01e-50 Height; CESC cis rs1018836 0.923 rs13267989 chr8:91581648 C/T cg16814680 chr8:91681699 NA -0.64 -8.72 -0.47 3.1e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9790314 0.521 rs13084731 chr3:161086020 G/A cg04691961 chr3:161091175 C3orf57 -0.37 -5.09 -0.3 6.66e-7 Morning vs. evening chronotype; CESC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg24549020 chr5:56110836 MAP3K1 0.66 7.44 0.42 1.37e-12 Initial pursuit acceleration; CESC cis rs113835537 0.529 rs11227495 chr11:66263243 C/T cg22134325 chr11:66188745 NPAS4 0.37 5.8 0.34 1.93e-8 Airway imaging phenotypes; CESC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg22467129 chr15:76604101 ETFA -0.38 -5.92 -0.34 1.01e-8 Blood metabolite levels; CESC cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg05347473 chr6:146136440 FBXO30 0.59 7.6 0.42 5.27e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs3820068 0.705 rs11584398 chr1:15880275 G/A cg17385448 chr1:15911702 AGMAT 0.36 5.62 0.33 4.77e-8 Systolic blood pressure; CESC cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg21214613 chr1:16344536 HSPB7 0.37 5.45 0.32 1.15e-7 Dilated cardiomyopathy; CESC cis rs4924935 1.000 rs1737947 chr17:18831432 A/G cg26378065 chr17:18585709 ZNF286B -0.49 -5.91 -0.34 1.05e-8 Pancreatic cancer; CESC cis rs2486288 0.554 rs1719235 chr15:45576108 A/G cg21132104 chr15:45694354 SPATA5L1 -0.62 -7.46 -0.42 1.27e-12 Glomerular filtration rate; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg13860548 chr1:15853252 DNAJC16 -0.43 -6.18 -0.35 2.44e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg22875332 chr1:76189707 ACADM 0.48 5.51 0.32 8.68e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg15017067 chr4:17643749 FAM184B 0.38 5.04 0.3 8.63e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs5769707 0.609 rs739247 chr22:49996657 T/C cg05373962 chr22:49881684 NA -0.35 -5.17 -0.3 4.61e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg10691866 chr7:65817282 TPST1 0.33 5.5 0.32 8.83e-8 Aortic root size; CESC cis rs9303280 0.806 rs62067034 chr17:38063738 C/T cg20243544 chr17:37824526 PNMT 0.56 7.37 0.41 2.23e-12 Self-reported allergy; CESC trans rs1909481 0.561 rs894086 chr8:137687996 C/A cg18579875 chr2:217540128 IGFBP5 -0.71 -6.29 -0.36 1.31e-9 Squamous cell lung carcinoma; CESC cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg10760299 chr15:45669010 GATM 0.38 5.22 0.31 3.65e-7 Homoarginine levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg21227347 chr9:117374170 C9orf91 0.5 6.57 0.37 2.72e-10 Systemic lupus erythematosus; CESC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.02 0.56 1.64e-23 Alzheimer's disease; CESC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg23758822 chr17:41437982 NA 1.0 15.37 0.69 1.56e-38 Menopause (age at onset); CESC cis rs4909189 1.000 rs62493649 chr7:158135556 C/G cg24154853 chr7:158122151 PTPRN2 0.46 6.2 0.36 2.22e-9 Response to amphetamines; CESC trans rs61931739 0.857 rs419112 chr12:34130528 A/G cg26384229 chr12:38710491 ALG10B 0.44 6.05 0.35 5.02e-9 Morning vs. evening chronotype; CESC cis rs10927875 0.541 rs1739843 chr1:16343254 T/C cg22431228 chr1:16359049 CLCNKA -0.52 -9.9 -0.52 7.22e-20 Dilated cardiomyopathy; CESC cis rs4642101 0.669 rs1467026 chr3:12830775 G/A cg24848339 chr3:12840334 CAND2 0.4 6.2 0.36 2.17e-9 QRS complex (12-leadsum); CESC cis rs9399135 0.967 rs9376082 chr6:135346389 T/A cg22676075 chr6:135203613 NA 0.5 7.17 0.4 7.65e-12 Red blood cell count; CESC trans rs1728785 1.000 rs1182968 chr16:68573945 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.02e-12 Ulcerative colitis; CESC cis rs9487051 0.704 rs1741930 chr6:109519797 T/A cg01475377 chr6:109611718 NA -0.37 -5.55 -0.32 6.99e-8 Reticulocyte fraction of red cells; CESC cis rs72781680 0.898 rs72782117 chr2:24026921 G/A cg08917208 chr2:24149416 ATAD2B 1.13 10.18 0.53 9.42e-21 Lymphocyte counts; CESC cis rs3733585 0.673 rs7377578 chr4:9952775 T/C cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.44e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.72 0.51 2.78e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2404602 0.647 rs11634266 chr15:77093461 A/G cg23625390 chr15:77176239 SCAPER -0.47 -6.51 -0.37 3.72e-10 Blood metabolite levels; CESC cis rs703842 1.000 rs6581155 chr12:58178162 A/G cg00677455 chr12:58241039 CTDSP2 0.52 6.86 0.39 4.8e-11 Multiple sclerosis; CESC cis rs6748734 1.000 rs4311055 chr2:241821017 T/C cg04034577 chr2:241836375 C2orf54 -0.49 -8.43 -0.46 2.18e-15 Urinary metabolites; CESC cis rs79976124 0.879 rs12214948 chr6:66633603 G/A cg07460842 chr6:66804631 NA 0.72 8.31 0.45 5.13e-15 Type 2 diabetes; CESC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg20203395 chr5:56204925 C5orf35 0.5 5.77 0.33 2.24e-8 Initial pursuit acceleration; CESC cis rs1348850 0.914 rs7591807 chr2:178252986 A/G cg22681709 chr2:178499509 PDE11A -0.43 -6.29 -0.36 1.33e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02576381 chr5:159827164 C5orf54 -0.67 -7.88 -0.44 8.77e-14 Gut microbiome composition (summer); CESC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg11764359 chr7:65958608 NA 0.89 13.06 0.63 1.99e-30 Aortic root size; CESC trans rs1814175 0.645 rs847627 chr11:49927177 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs7084402 0.967 rs1626606 chr10:60328088 C/T cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs1983170 1.000 rs12563578 chr1:91993702 T/C cg25838465 chr1:92012736 NA 0.46 5.49 0.32 9.64e-8 Eosinophil percentage of white cells; CESC cis rs10463316 0.894 rs3905511 chr5:150768204 G/A cg03212797 chr5:150827313 SLC36A1 -0.47 -6.15 -0.35 2.86e-9 Metabolite levels (Pyroglutamine); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg02621907 chr5:93954419 ANKRD32;C5orf36 0.47 6.05 0.35 4.93e-9 Tetralogy of Fallot; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23333220 chr15:64679825 TRIP4 -0.43 -6.0 -0.35 6.42e-9 Gambling; CESC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg22143856 chr6:28129313 ZNF389 0.53 6.71 0.38 1.2e-10 Depression; CESC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg26752003 chr8:145688521 CYHR1 0.46 6.36 0.36 8.99e-10 Age at first birth; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg08839451 chr12:125478775 BRI3BP 0.51 6.16 0.35 2.62e-9 Psoriatic arthritis; CESC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg18252515 chr7:66147081 NA 0.44 5.85 0.34 1.48e-8 Aortic root size; CESC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.26 -0.36 1.55e-9 Menopause (age at onset); CESC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg16262614 chr3:133464971 TF 0.3 5.33 0.31 2.11e-7 Iron status biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20291513 chr1:207226369 PFKFB2 -0.57 -6.49 -0.37 4.31e-10 Gut microbiome composition (summer); CESC cis rs62064224 0.614 rs9900089 chr17:30772577 C/T cg18200150 chr17:30822561 MYO1D 0.41 5.26 0.31 2.92e-7 Schizophrenia; CESC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg18538332 chr22:24372958 LOC391322 -0.75 -10.94 -0.56 3.01e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7224737 1.000 rs7214921 chr17:40294025 T/C cg20291162 chr17:40259547 DHX58 -0.4 -5.48 -0.32 9.96e-8 Fibrinogen levels; CESC cis rs2730245 0.645 rs4909282 chr7:158699797 T/C cg24397884 chr7:158709396 WDR60 0.68 9.9 0.52 7.06e-20 Height; CESC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.13 -0.3 5.47e-7 Glomerular filtration rate (creatinine); CESC cis rs11997175 0.846 rs7388664 chr8:33768773 T/G ch.8.33884649F chr8:33765107 NA 0.77 10.29 0.53 4.24e-21 Body mass index; CESC cis rs8072100 0.875 rs4794047 chr17:45763005 A/T cg08085267 chr17:45401833 C17orf57 0.45 5.99 0.35 6.76e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18537085 chr2:70120936 SNRNP27 -0.55 -6.33 -0.36 1.03e-9 Gut microbiome composition (summer); CESC cis rs1949733 0.628 rs1543246 chr4:8504909 A/T cg11789530 chr4:8429930 ACOX3 0.65 9.1 0.49 2.17e-17 Response to antineoplastic agents; CESC cis rs1215050 0.791 rs260899 chr4:98707046 G/A cg05340658 chr4:99064831 C4orf37 0.5 6.4 0.37 7.13e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9549367 0.713 rs3024776 chr13:113827075 A/G cg00898013 chr13:113819073 PROZ 0.57 7.97 0.44 4.61e-14 Platelet distribution width; CESC cis rs9911578 1.000 rs9904879 chr17:56864422 G/A cg05425664 chr17:57184151 TRIM37 -0.49 -6.87 -0.39 4.62e-11 Intelligence (multi-trait analysis); CESC cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs1814175 0.817 rs7927373 chr11:49957640 A/C cg03929089 chr4:120376271 NA -0.93 -15.75 -0.7 6.66e-40 Height; CESC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg06634786 chr22:41940651 POLR3H -0.63 -6.3 -0.36 1.23e-9 Vitiligo; CESC cis rs1801251 1.000 rs6724117 chr2:233593660 T/G cg08000102 chr2:233561755 GIGYF2 0.68 9.59 0.51 7.1e-19 Coronary artery disease; CESC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg07701084 chr6:150067640 NUP43 0.45 6.39 0.37 7.37e-10 Lung cancer; CESC cis rs2228479 0.850 rs62056091 chr16:89930414 G/A cg14709524 chr16:89940631 TCF25 0.87 6.18 0.35 2.43e-9 Skin colour saturation; CESC cis rs17293817 0.914 rs34447234 chr10:1440517 G/A cg08482957 chr10:1437944 ADARB2 0.36 5.28 0.31 2.75e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9649465 1.000 rs10270877 chr7:123327860 T/C cg04330084 chr7:123175371 IQUB -0.38 -5.16 -0.3 4.75e-7 Migraine; CESC cis rs17376456 0.877 rs10052428 chr5:93476530 T/C cg25358565 chr5:93447407 FAM172A 1.17 11.51 0.58 3.92e-25 Diabetic retinopathy; CESC cis rs9300255 0.596 rs10773002 chr12:123746961 A/T cg00376283 chr12:123451042 ABCB9 -0.67 -9.14 -0.49 1.68e-17 Neutrophil percentage of white cells; CESC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.47 -0.37 4.81e-10 Life satisfaction; CESC cis rs2732480 0.500 rs7966829 chr12:48615603 G/T cg24011408 chr12:48396354 COL2A1 0.45 6.23 0.36 1.87e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7264396 0.790 rs6058297 chr20:34271861 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.81 0.43 1.36e-13 Total cholesterol levels; CESC cis rs920590 0.758 rs35896770 chr8:19665616 G/C cg01411142 chr8:19674711 INTS10 0.56 6.41 0.37 6.77e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 2e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6831352 0.879 rs29001208 chr4:100052539 A/C cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs854765 0.647 rs4365346 chr17:17989373 G/T cg16928487 chr17:17741425 SREBF1 -0.53 -8.76 -0.47 2.34e-16 Total body bone mineral density; CESC cis rs7980687 0.628 rs1727332 chr12:123718301 C/T cg05973401 chr12:123451056 ABCB9 0.46 5.63 0.33 4.68e-8 Height;Educational attainment;Head circumference (infant); CESC cis rs1865760 0.566 rs2794720 chr6:26087202 G/C cg16482183 chr6:26056742 HIST1H1C 0.38 5.11 0.3 6.19e-7 Height; CESC cis rs7116495 1.000 rs542752 chr11:71810644 T/A cg10381502 chr11:71823885 C11orf51 0.66 5.35 0.31 1.93e-7 Severe influenza A (H1N1) infection; CESC cis rs660899 0.595 rs37458 chr1:44290530 A/G cg19743044 chr1:44115203 KDM4A 0.47 5.95 0.34 8.62e-9 Hypertension risk in short sleep duration; CESC cis rs7582720 1.000 rs72934764 chr2:203758521 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs892961 0.932 rs67719929 chr17:75412605 G/A cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs4964805 0.626 rs869993 chr12:104175138 A/T cg02344784 chr12:104178138 NT5DC3 0.41 5.72 0.33 2.93e-8 Attention deficit hyperactivity disorder; CESC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg23758822 chr17:41437982 NA 1.03 15.83 0.7 3.63e-40 Menopause (age at onset); CESC trans rs66573146 1.000 rs66573146 chr4:6984464 C/G cg07817883 chr1:32538562 TMEM39B 1.48 9.1 0.49 2.16e-17 Granulocyte percentage of myeloid white cells; CESC cis rs4253772 0.938 rs41427746 chr22:46637239 T/C cg18190219 chr22:46762943 CELSR1 -0.58 -6.96 -0.39 2.71e-11 LDL cholesterol;Cholesterol, total; CESC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -11.0 -0.56 1.9e-23 Alzheimer's disease; CESC cis rs10242455 0.702 rs73711294 chr7:99088714 G/A cg25640893 chr7:99214727 ZNF498 0.76 5.39 0.31 1.58e-7 Blood metabolite levels; CESC cis rs62344088 1.000 rs6872393 chr5:155854 A/G cg22857025 chr5:266934 NA 0.97 5.5 0.32 9e-8 Asthma (childhood onset); CESC cis rs3008870 1.000 rs3008858 chr1:67390416 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.03 0.68 2.49e-37 Lymphocyte percentage of white cells; CESC cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg20476274 chr7:133979776 SLC35B4 0.67 9.79 0.52 1.65e-19 Mean platelet volume; CESC cis rs941873 0.835 rs10762859 chr10:81103370 T/A cg09469691 chr10:81107165 PPIF 0.56 7.52 0.42 8.38e-13 Height; CESC cis rs6977660 0.598 rs72591445 chr7:19773035 G/A cg07541023 chr7:19748670 TWISTNB 0.81 7.31 0.41 3.21e-12 Thyroid stimulating hormone; CESC cis rs17384381 0.700 rs11161617 chr1:85913538 A/G cg16011679 chr1:85725395 C1orf52 0.56 6.49 0.37 4.18e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9287719 0.967 rs2110778 chr2:10748970 A/T cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs3733585 0.699 rs12498150 chr4:9950537 C/T cg00071950 chr4:10020882 SLC2A9 -0.71 -11.91 -0.59 1.77e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7605827 0.893 rs6734024 chr2:15718180 A/G cg19274914 chr2:15703543 NA 0.35 6.36 0.36 8.56e-10 Educational attainment (years of education); CESC cis rs4076764 0.914 rs12123378 chr1:163377846 C/T cg24596788 chr1:163392923 NA -0.53 -7.81 -0.43 1.3e-13 Motion sickness; CESC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg07308232 chr7:1071921 C7orf50 0.5 7.11 0.4 1.1e-11 Longevity;Endometriosis; CESC cis rs6815814 0.898 rs1106956 chr4:38889811 A/G cg02016764 chr4:38805732 TLR1 -0.56 -6.56 -0.37 2.74e-10 Breast cancer; CESC cis rs9818941 0.824 rs11707532 chr3:157801867 T/C cg08654915 chr3:157813417 NA 0.46 7.53 0.42 8.12e-13 Height; CESC cis rs2832191 0.716 rs2249028 chr21:30365322 G/A cg08807101 chr21:30365312 RNF160 0.96 14.98 0.68 3.51e-37 Dental caries; CESC cis rs34779708 0.966 rs12773647 chr10:35440327 A/G cg04310649 chr10:35416472 CREM -0.5 -6.12 -0.35 3.27e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs870825 0.616 rs4444873 chr4:185628406 A/G cg04058563 chr4:185651563 MLF1IP 0.65 7.07 0.4 1.36e-11 Blood protein levels; CESC cis rs7191439 0.858 rs6500489 chr16:88772046 T/C cg02389323 chr16:88786976 FAM38A 0.85 5.95 0.34 8.57e-9 Plateletcrit; CESC cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg05585544 chr11:47624801 NA 0.5 7.29 0.41 3.57e-12 Subjective well-being; CESC cis rs9814567 1.000 rs6785027 chr3:134211649 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.44 6.06 0.35 4.53e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2204008 0.666 rs67792345 chr12:38204698 T/C cg26384229 chr12:38710491 ALG10B 0.73 10.16 0.53 1.08e-20 Bladder cancer; CESC cis rs921968 0.565 rs6436073 chr2:219618237 A/C cg02176678 chr2:219576539 TTLL4 -0.43 -7.56 -0.42 6.81e-13 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10328259 chr2:3321226 TSSC1 -0.75 -8.79 -0.48 1.9e-16 Gut microbiome composition (summer); CESC cis rs7546094 1.000 rs12728001 chr1:113076756 T/C cg22162597 chr1:113214053 CAPZA1 0.35 5.22 0.31 3.63e-7 Platelet distribution width; CESC cis rs7084402 0.902 rs1658417 chr10:60333039 T/C cg07615347 chr10:60278583 BICC1 0.59 9.23 0.49 9.22e-18 Refractive error; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg15190599 chr6:26156487 HIST1H1E -0.5 -6.53 -0.37 3.38e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg00684032 chr4:1343700 KIAA1530 0.43 5.69 0.33 3.33e-8 Obesity-related traits; CESC cis rs10992471 0.756 rs10115222 chr9:95128149 C/T cg13798575 chr9:95087839 CENPP;NOL8 0.45 5.67 0.33 3.68e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13476105 chr17:7819425 LOC284023 -0.43 -6.27 -0.36 1.48e-9 Gambling; CESC cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg12365402 chr11:9010492 NRIP3 -0.33 -5.25 -0.31 3.05e-7 Hemoglobin concentration; CESC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.66 0.43 3.42e-13 Prudent dietary pattern; CESC cis rs524281 0.731 rs10791838 chr11:65789854 T/G cg14036092 chr11:66035641 RAB1B -0.62 -5.59 -0.32 5.57e-8 Electroencephalogram traits; CESC trans rs11039798 1.000 rs7942284 chr11:48520424 A/G cg15704280 chr7:45808275 SEPT13 -0.68 -6.22 -0.36 1.96e-9 Axial length; CESC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg05368731 chr17:41323189 NBR1 0.75 10.35 0.54 2.72e-21 Menopause (age at onset); CESC cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.79 8.26 0.45 6.82e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs61931739 0.500 rs11053194 chr12:34440841 A/G cg23762105 chr12:34175262 ALG10 -0.4 -5.22 -0.31 3.7e-7 Morning vs. evening chronotype; CESC cis rs6466055 0.692 rs4727621 chr7:105028370 T/C cg04380332 chr7:105027541 SRPK2 -0.42 -5.37 -0.31 1.74e-7 Schizophrenia; CESC cis rs2742234 0.504 rs10899780 chr10:43725796 T/C cg07801480 chr10:43725741 RASGEF1A -0.42 -5.32 -0.31 2.19e-7 Hirschsprung disease; CESC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg10691866 chr7:65817282 TPST1 0.33 5.51 0.32 8.51e-8 Aortic root size; CESC cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg12386194 chr3:101231763 SENP7 0.44 5.48 0.32 9.88e-8 Colorectal cancer; CESC cis rs4925386 0.840 rs6143035 chr20:60920700 C/T cg22633769 chr20:60982531 CABLES2 -0.52 -5.53 -0.32 7.58e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs2354432 0.607 rs9782976 chr1:146825049 A/G cg25205988 chr1:146714368 CHD1L 0.77 8.2 0.45 1.01e-14 Mitochondrial DNA levels; CESC cis rs11638352 0.661 rs2555382 chr15:44424316 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.56 5.29 0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs7267979 1.000 rs6037086 chr20:25306338 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.08 -0.7 4.65e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs6460942 0.597 rs10273045 chr7:12519371 T/C cg06484146 chr7:12443880 VWDE -0.64 -7.13 -0.4 9.4e-12 Coronary artery disease; CESC cis rs67478160 0.584 rs2295147 chr14:104195664 A/G cg01849466 chr14:104193079 ZFYVE21 0.56 8.34 0.46 4.02e-15 Schizophrenia; CESC cis rs317689 0.702 rs544696 chr12:69749939 T/C cg14784868 chr12:69753453 YEATS4 0.74 9.78 0.52 1.72e-19 Response to diuretic therapy; CESC cis rs225245 0.782 rs321618 chr17:33912404 A/G cg05299278 chr17:33885742 SLFN14 0.38 5.46 0.32 1.08e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs397969 0.596 rs35925051 chr17:19877369 G/A cg12073167 chr17:19770448 ULK2 -0.49 -5.91 -0.34 1.06e-8 Platelet count; CESC cis rs6964587 0.605 rs6956022 chr7:91553199 A/G cg17063962 chr7:91808500 NA -0.45 -6.29 -0.36 1.29e-9 Breast cancer; CESC cis rs6460942 0.915 rs17324858 chr7:12305792 G/T cg02935154 chr7:12443704 VWDE -0.4 -5.58 -0.32 5.94e-8 Coronary artery disease; CESC cis rs72781680 0.583 rs6731333 chr2:24113354 C/T cg08917208 chr2:24149416 ATAD2B 0.6 6.27 0.36 1.44e-9 Lymphocyte counts; CESC trans rs11098499 0.780 rs7692994 chr4:120427489 C/A cg25214090 chr10:38739885 LOC399744 0.69 9.53 0.51 1.03e-18 Corneal astigmatism; CESC trans rs61931739 0.500 rs10844848 chr12:34409705 A/C cg13010199 chr12:38710504 ALG10B 0.49 6.33 0.36 1.02e-9 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04400940 chr3:150329548 SELT 0.53 6.93 0.39 3.14e-11 Fibrinogen levels; CESC cis rs7666738 0.830 rs9998582 chr4:98938949 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs67311347 1.000 rs17078511 chr3:40396254 A/G cg09455208 chr3:40491958 NA 0.53 9.34 0.5 4.14e-18 Renal cell carcinoma; CESC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg18876405 chr7:65276391 NA -0.56 -7.3 -0.41 3.35e-12 Aortic root size; CESC cis rs523522 0.962 rs655530 chr12:121022275 T/C cg27279351 chr12:120934652 DYNLL1 0.7 9.06 0.49 2.86e-17 High light scatter reticulocyte count; CESC cis rs2228479 0.717 rs12917681 chr16:89810941 C/A cg14709524 chr16:89940631 TCF25 0.62 5.59 0.33 5.51e-8 Skin colour saturation; CESC cis rs4474465 0.850 rs4945294 chr11:78256864 G/A cg27205649 chr11:78285834 NARS2 0.42 5.4 0.31 1.49e-7 Alzheimer's disease (survival time); CESC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg15445000 chr17:37608096 MED1 -0.42 -6.87 -0.39 4.46e-11 Glomerular filtration rate (creatinine); CESC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg24060327 chr5:131705240 SLC22A5 -0.47 -6.09 -0.35 4.03e-9 Acylcarnitine levels; CESC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.06 0.3 7.82e-7 Lung cancer; CESC cis rs12950390 0.853 rs11079792 chr17:45863311 T/C cg00777063 chr17:45855553 NA -0.38 -5.64 -0.33 4.24e-8 IgG glycosylation; CESC trans rs35110281 0.782 rs2051407 chr21:45079245 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 6.79 0.38 7.48e-11 Mean corpuscular volume; CESC cis rs11190604 1.000 rs11190601 chr10:102296730 A/G cg07080220 chr10:102295463 HIF1AN 0.7 6.5 0.37 3.99e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs6460942 0.915 rs72584550 chr7:12304990 G/A cg02935154 chr7:12443704 VWDE -0.41 -5.57 -0.32 6.15e-8 Coronary artery disease; CESC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg13880726 chr7:1868755 MAD1L1 0.53 7.11 0.4 1.05e-11 Bipolar disorder and schizophrenia; CESC cis rs2243480 0.901 rs2900904 chr7:65204264 C/G cg13147721 chr7:65941812 NA -0.88 -8.07 -0.44 2.51e-14 Diabetic kidney disease; CESC cis rs4843747 0.671 rs8062855 chr16:88106941 T/C cg06374794 chr16:88002281 BANP 0.39 5.16 0.3 4.78e-7 Menopause (age at onset); CESC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.85 0.39 5.2e-11 Electroencephalogram traits; CESC cis rs854765 0.547 rs2955355 chr17:17948475 G/A cg16928487 chr17:17741425 SREBF1 0.57 9.8 0.52 1.45e-19 Total body bone mineral density; CESC trans rs1814175 0.559 rs1818892 chr11:49863084 C/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.51e-9 Height; CESC cis rs7662987 0.517 rs2602858 chr4:100030461 T/C cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC cis rs804292 0.695 rs804279 chr8:11623889 A/T cg26752888 chr8:11627280 NEIL2 0.73 9.41 0.5 2.48e-18 Alcohol dependence;Nicotine use; CESC cis rs732765 0.648 rs8019391 chr14:75409682 T/C cg06642626 chr14:75180534 FCF1;KIAA0317 -0.37 -5.38 -0.31 1.68e-7 Non-small cell lung cancer; CESC cis rs9291683 0.595 rs3733585 chr4:10036339 A/G cg11266682 chr4:10021025 SLC2A9 0.7 13.81 0.65 4.81e-33 Bone mineral density; CESC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg23281280 chr6:28129359 ZNF389 0.59 8.16 0.45 1.34e-14 Depression; CESC cis rs854765 0.562 rs2955381 chr17:17945500 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.81 -0.48 1.7e-16 Total body bone mineral density; CESC cis rs12579753 0.917 rs7132732 chr12:82206053 C/G cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs6723226 1.000 rs6723226 chr2:32849207 C/T cg02381751 chr2:32503542 YIPF4 0.69 9.23 0.49 8.95e-18 Intelligence (multi-trait analysis); CESC cis rs11098499 0.820 rs28535956 chr4:120536858 C/T cg09307838 chr4:120376055 NA -0.86 -11.86 -0.59 2.69e-26 Corneal astigmatism; CESC cis rs17023223 0.537 rs10923754 chr1:119668640 T/C cg05756136 chr1:119680316 WARS2 -0.46 -5.64 -0.33 4.42e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC trans rs17181170 0.553 rs6795510 chr3:87174568 C/T ch.2.199792288R chr2:200084043 NA -0.44 -6.05 -0.35 4.97e-9 Prostate cancer; CESC cis rs7259376 0.875 rs1091182 chr19:22475622 G/A cg02657401 chr19:22469223 NA 0.26 5.29 0.31 2.52e-7 Menopause (age at onset); CESC cis rs7246865 0.954 rs3745348 chr19:17212410 C/T cg19418318 chr19:17219073 MYO9B 0.36 6.05 0.35 4.86e-9 Reticulocyte fraction of red cells; CESC cis rs10791323 0.569 rs2187450 chr11:133743792 A/G cg15485101 chr11:133734466 NA 0.3 5.22 0.31 3.6e-7 Childhood ear infection; CESC cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg05340658 chr4:99064831 C4orf37 0.78 11.93 0.59 1.51e-26 Colonoscopy-negative controls vs population controls; CESC cis rs2625529 0.824 rs4777471 chr15:72207804 A/G cg16672083 chr15:72433130 SENP8 -0.39 -5.09 -0.3 6.78e-7 Red blood cell count; CESC cis rs55823223 0.648 rs936393 chr17:73847613 A/G cg08125733 chr17:73851984 WBP2 0.89 11.82 0.59 3.46e-26 Psoriasis; CESC cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg05340658 chr4:99064831 C4orf37 -0.79 -12.52 -0.61 1.46e-28 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.583 rs28428991 chr17:17827649 C/T cg16928487 chr17:17741425 SREBF1 -0.57 -9.74 -0.51 2.41e-19 Total body bone mineral density; CESC cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg25894440 chr7:65020034 NA -0.64 -5.46 -0.32 1.1e-7 Diabetic kidney disease; CESC cis rs6674970 0.518 rs15740 chr1:151040435 G/A cg03258749 chr1:151040405 MLLT11 -0.45 -6.08 -0.35 4.15e-9 Childhood ear infection; CESC cis rs17253792 0.822 rs17253716 chr14:56153661 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg21724239 chr8:58056113 NA 0.56 5.76 0.33 2.34e-8 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19882826 chr6:37787165 ZFAND3 0.57 6.28 0.36 1.4e-9 Gut microbiome composition (summer); CESC cis rs10752881 0.935 rs10911235 chr1:183053746 G/A ch.1.3577855R chr1:183094577 LAMC1 0.85 13.7 0.64 1.21e-32 Colorectal cancer; CESC cis rs116095464 0.558 rs6879656 chr5:264428 T/C cg22857025 chr5:266934 NA -1.32 -15.79 -0.7 4.9e-40 Breast cancer; CESC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg04317338 chr11:64019027 PLCB3 0.47 5.57 0.32 6.34e-8 Platelet count; CESC cis rs17376456 0.825 rs10057130 chr5:93282557 C/T cg21475434 chr5:93447410 FAM172A 0.77 6.39 0.37 7.61e-10 Diabetic retinopathy; CESC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg22520471 chr17:61851767 DDX42;CCDC47 0.87 12.72 0.62 2.99e-29 Prudent dietary pattern; CESC cis rs2115536 1.000 rs11637477 chr15:80193295 C/T cg00225070 chr15:80189496 MTHFS 0.6 8.48 0.46 1.65e-15 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs6665290 0.935 rs17600669 chr1:227201871 A/G cg10327440 chr1:227177885 CDC42BPA -1.2 -31.15 -0.89 1.43e-90 Myeloid white cell count; CESC cis rs2243480 1.000 rs78803505 chr7:65382572 A/T cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC cis rs3008870 0.755 rs1570838 chr1:67403315 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.63 8.34 0.46 4.16e-15 Lymphocyte percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18269826 chr15:101459483 LRRK1 -0.4 -6.05 -0.35 4.93e-9 Fibrinogen levels; CESC cis rs1152591 0.669 rs2978381 chr14:64766652 T/C cg21174375 chr14:64681225 SYNE2 0.55 7.23 0.41 5.29e-12 Atrial fibrillation; CESC cis rs9916302 0.904 rs11078910 chr17:37671269 G/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 4.03e-10 Glomerular filtration rate (creatinine); CESC cis rs559928 0.556 rs11607903 chr11:63932140 G/A cg18225595 chr11:63971243 STIP1 0.69 6.22 0.36 1.88e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg23281280 chr6:28129359 ZNF389 0.55 7.31 0.41 3.21e-12 Depression; CESC cis rs7577696 0.597 rs212689 chr2:32437338 G/A cg02381751 chr2:32503542 YIPF4 0.46 5.16 0.3 4.77e-7 Inflammatory biomarkers; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08393828 chr14:102228221 PPP2R5C 0.5 6.3 0.36 1.27e-9 Gut microbiota (bacterial taxa); CESC cis rs10887741 0.690 rs4934358 chr10:89439744 C/A cg13926569 chr10:89418898 PAPSS2 0.35 5.23 0.31 3.39e-7 Exercise (leisure time); CESC cis rs3960554 0.808 rs78587454 chr7:75688672 G/A cg17325771 chr7:75508891 RHBDD2 -0.36 -5.24 -0.31 3.25e-7 Eotaxin levels; CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg05564831 chr3:52568323 NT5DC2 0.48 7.81 0.43 1.32e-13 Electroencephalogram traits; CESC cis rs6032067 0.636 rs7272597 chr20:43908869 T/C cg10761708 chr20:43804764 PI3 0.38 5.07 0.3 7.6e-7 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21518056 chr19:33183187 NUDT19 -0.48 -6.24 -0.36 1.68e-9 Fibrinogen levels; CESC cis rs8067354 0.540 rs72840315 chr17:58018142 G/C cg02344993 chr17:57696989 CLTC 0.52 5.52 0.32 8.03e-8 Hemoglobin concentration; CESC cis rs28647808 0.881 rs28461467 chr9:136261288 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs2288073 0.965 rs6545340 chr2:24422269 C/G cg06627628 chr2:24431161 ITSN2 -0.81 -9.75 -0.51 2.14e-19 Venous thromboembolism (SNP x SNP interaction); CESC cis rs7267979 0.816 rs6037158 chr20:25595466 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.35 0.66 6.13e-35 Liver enzyme levels (alkaline phosphatase); CESC cis rs1832871 0.711 rs9457248 chr6:158681204 C/T cg07165851 chr6:158734300 TULP4 0.59 6.36 0.36 8.84e-10 Height; CESC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg04267008 chr7:1944627 MAD1L1 0.62 7.79 0.43 1.5e-13 Bipolar disorder and schizophrenia; CESC cis rs9916302 0.861 rs7503514 chr17:37669884 G/C cg00129232 chr17:37814104 STARD3 -0.56 -7.49 -0.42 1e-12 Glomerular filtration rate (creatinine); CESC cis rs1559088 0.545 rs7257431 chr19:33566924 A/G cg27124370 chr19:33622961 WDR88 0.54 7.51 0.42 9.05e-13 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1256061 0.603 rs3020445 chr14:64788644 A/G cg21174375 chr14:64681225 SYNE2 0.54 7.04 0.4 1.62e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07364676 chr22:29137974 CHEK2;HSCB -0.41 -6.54 -0.37 3.13e-10 Gambling; CESC cis rs3749237 0.595 rs12489092 chr3:49550914 G/C cg03060546 chr3:49711283 APEH 0.77 11.8 0.59 4.14e-26 Resting heart rate; CESC cis rs34734847 1.000 rs2948149 chr12:121162854 T/G cg21892295 chr12:121157589 UNC119B -0.39 -6.17 -0.35 2.56e-9 Mean corpuscular volume; CESC cis rs7208859 0.623 rs216433 chr17:28921860 T/C cg19761014 chr17:28927070 LRRC37B2 0.8 7.38 0.41 2.04e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs5769765 0.954 rs910799 chr22:50278568 A/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.49 -0.32 9.25e-8 Schizophrenia; CESC cis rs412050 0.895 rs6000236 chr22:22296459 A/G cg17089214 chr22:22089827 YPEL1 0.73 6.94 0.39 2.93e-11 Attention deficit hyperactivity disorder; CESC cis rs73206853 0.841 rs7956963 chr12:110947783 G/A cg12870014 chr12:110450643 ANKRD13A 0.63 5.22 0.31 3.56e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.53 -7.24 -0.41 4.87e-12 Menarche (age at onset); CESC cis rs4919087 0.715 rs34787876 chr10:98999213 T/C cg25902810 chr10:99078978 FRAT1 -0.46 -5.2 -0.3 4.03e-7 Monocyte count; CESC cis rs9325144 0.647 rs61931899 chr12:38892422 A/G cg26384229 chr12:38710491 ALG10B -0.55 -7.65 -0.43 3.64e-13 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.59 0.47 7.72e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1322639 0.614 rs6900200 chr6:169566173 T/C cg03254818 chr6:169586852 NA 0.49 5.31 0.31 2.29e-7 Pulse pressure; CESC cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg24112000 chr20:60950667 NA -0.56 -7.0 -0.4 2.04e-11 Colorectal cancer; CESC cis rs3008870 1.000 rs17497828 chr1:67452322 G/A cg02640540 chr1:67518911 SLC35D1 -0.51 -5.33 -0.31 2.06e-7 Lymphocyte percentage of white cells; CESC cis rs6032067 0.929 rs7344269 chr20:43828668 C/T cg11264863 chr20:43835661 SEMG1 -0.48 -5.32 -0.31 2.25e-7 Blood protein levels; CESC cis rs34779708 0.931 rs12773169 chr10:35366462 G/C cg04310649 chr10:35416472 CREM -0.52 -6.27 -0.36 1.42e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9303401 0.614 rs35308719 chr17:57163501 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.88 11.1 0.56 9.23e-24 Cognitive test performance; CESC cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg02551604 chr5:131831745 NA 0.38 5.26 0.31 3e-7 Asthma (sex interaction); CESC cis rs9911578 0.967 rs6416932 chr17:57148991 G/A cg05425664 chr17:57184151 TRIM37 -0.53 -7.23 -0.41 5.28e-12 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01560493 chr5:109024808 MAN2A1 0.47 6.02 0.35 5.66e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.52 0.46 1.24e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9399135 0.967 rs3756799 chr6:135341011 A/G cg22676075 chr6:135203613 NA 0.51 7.37 0.41 2.22e-12 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04932230 chr10:54073878 DKK1 -0.53 -6.91 -0.39 3.67e-11 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.67 0.64 1.52e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs5769765 0.955 rs61136468 chr22:50312679 A/G cg02269571 chr22:50332266 NA -0.5 -6.58 -0.37 2.45e-10 Schizophrenia; CESC cis rs2191566 0.960 rs7255315 chr19:44510933 A/T cg20607764 chr19:44506953 ZNF230 -0.58 -7.63 -0.42 4.31e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs11122272 0.735 rs2491404 chr1:231512127 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs1707322 0.721 rs11211166 chr1:46157942 G/A cg06784218 chr1:46089804 CCDC17 0.43 7.63 0.42 4.11e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg18404041 chr3:52824283 ITIH1 0.4 6.78 0.38 7.65e-11 Bipolar disorder; CESC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg07677032 chr17:61819896 STRADA 0.42 5.29 0.31 2.57e-7 Height; CESC cis rs362272 0.545 rs2748447 chr4:3337831 G/A cg14583973 chr4:3374767 RGS12 0.33 5.78 0.33 2.15e-8 Serum sulfate level; CESC cis rs818427 0.593 rs456531 chr5:112216189 T/C cg07820702 chr5:112228657 REEP5 -0.39 -5.1 -0.3 6.42e-7 Total body bone mineral density; CESC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg18337363 chr3:52569053 NT5DC2 0.28 5.24 0.31 3.22e-7 Bipolar disorder; CESC cis rs9911578 0.935 rs9911753 chr17:56983174 G/A cg05425664 chr17:57184151 TRIM37 -0.39 -5.34 -0.31 2.02e-7 Intelligence (multi-trait analysis); CESC cis rs4654899 0.733 rs10442633 chr1:21265097 C/T cg05370193 chr1:21551575 ECE1 0.38 5.72 0.33 2.83e-8 Superior frontal gyrus grey matter volume; CESC cis rs9902453 0.935 rs9905950 chr17:28431198 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 8.65 0.47 5.09e-16 Coffee consumption (cups per day); CESC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg04166393 chr7:2884313 GNA12 0.53 6.96 0.39 2.71e-11 Height; CESC cis rs6662572 0.737 rs7413189 chr1:46254330 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.03 -0.3 9.07e-7 Blood protein levels; CESC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.11 -12.68 -0.61 4.13e-29 Gut microbiome composition (summer); CESC cis rs35123781 1.000 rs585101 chr5:139058454 T/C cg10513866 chr5:139070639 NA 0.41 5.98 0.34 7.05e-9 Schizophrenia; CESC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2074977 0.500 rs10153493 chr19:3447745 C/T cg08380311 chr19:3435252 NFIC -0.39 -5.16 -0.3 4.92e-7 Height; CESC cis rs11997175 0.536 rs10096323 chr8:33776507 T/C ch.8.33884649F chr8:33765107 NA 0.54 6.45 0.37 5.25e-10 Body mass index; CESC cis rs10791097 0.694 rs1893018 chr11:130756632 T/C cg09137382 chr11:130731461 NA 0.35 5.21 0.3 3.81e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6964587 1.000 rs6960867 chr7:91712698 A/G cg17063962 chr7:91808500 NA 0.53 7.09 0.4 1.25e-11 Breast cancer; CESC cis rs7223966 1.000 rs8075273 chr17:61728881 G/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.54 -5.5 -0.32 9e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.63 5.55 0.32 6.79e-8 Depression; CESC cis rs16854884 1.000 rs13068298 chr3:143772247 T/C cg06585982 chr3:143692056 C3orf58 0.46 5.68 0.33 3.47e-8 Economic and political preferences (feminism/equality); CESC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs763014 0.931 rs2071981 chr16:630025 C/G cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.35e-9 Height; CESC cis rs863345 0.967 rs11265030 chr1:158529388 A/G cg12129480 chr1:158549410 OR10X1 0.33 6.95 0.39 2.8e-11 Pneumococcal bacteremia; CESC cis rs2932538 0.922 rs12406906 chr1:113117900 G/T cg22162597 chr1:113214053 CAPZA1 -0.51 -6.78 -0.38 7.59e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs9297145 0.724 rs62473013 chr7:98762418 G/T cg05967295 chr7:98741636 SMURF1 0.9 9.34 0.5 4.06e-18 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs4727027 0.705 rs10952803 chr7:148890091 T/G cg23583168 chr7:148888333 NA -0.97 -17.53 -0.73 3.38e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7605827 0.866 rs35237017 chr2:15615704 T/C cg19274914 chr2:15703543 NA 0.33 5.96 0.34 8.22e-9 Educational attainment (years of education); CESC cis rs4065321 0.609 rs8075668 chr17:38137623 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.4 5.81 0.34 1.75e-8 White blood cell count (basophil);White blood cell count; CESC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg00149659 chr3:10157352 C3orf10 0.74 9.14 0.49 1.63e-17 Alzheimer's disease; CESC cis rs854765 0.522 rs63721860 chr17:17829576 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.2 0.36 2.16e-9 Total body bone mineral density; CESC cis rs589448 0.902 rs642786 chr12:69758462 T/C cg14784868 chr12:69753453 YEATS4 0.89 14.23 0.66 1.66e-34 Cerebrospinal fluid biomarker levels; CESC cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs2832191 0.647 rs11170 chr21:30378090 C/T cg08807101 chr21:30365312 RNF160 0.9 13.24 0.63 4.68e-31 Dental caries; CESC cis rs6912958 0.712 rs4587138 chr6:88356915 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.22 -0.31 3.56e-7 Monocyte percentage of white cells; CESC cis rs2283792 0.812 rs5995269 chr22:22289397 G/A cg17089214 chr22:22089827 YPEL1 0.42 5.04 0.3 8.77e-7 Multiple sclerosis; CESC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg07701084 chr6:150067640 NUP43 0.43 5.85 0.34 1.45e-8 Lung cancer; CESC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.27 0.53 4.68e-21 Prudent dietary pattern; CESC cis rs1879734 0.731 rs6588487 chr1:54166790 G/A cg23596471 chr1:54105337 GLIS1 0.35 5.51 0.32 8.39e-8 Mitral valve prolapse; CESC cis rs1475911 0.708 rs8129075 chr21:43523430 G/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.95 12.87 0.62 9.38e-30 IgG glycosylation; CESC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.2 0.81 2.11e-62 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07624948 chr16:28962847 NFATC2IP 0.44 6.06 0.35 4.73e-9 Fibrinogen levels; CESC cis rs13272623 0.502 rs268599 chr8:71517401 G/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.21 -0.3 3.77e-7 IgG glycosylation; CESC cis rs6582630 0.519 rs11514056 chr12:38284001 G/T cg26384229 chr12:38710491 ALG10B 0.65 9.03 0.49 3.55e-17 Drug-induced liver injury (flucloxacillin); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20181887 chr12:123753272 CDK2AP1 -0.49 -6.09 -0.35 4e-9 Gut microbiome composition (summer); CESC cis rs10927875 0.596 rs1806990 chr1:16129377 G/A cg18973939 chr1:16164122 FLJ37453 0.37 5.58 0.32 6.01e-8 Dilated cardiomyopathy; CESC cis rs250677 1.000 rs36069 chr5:148417253 G/C cg18129178 chr5:148520854 ABLIM3 -0.49 -5.79 -0.33 2.04e-8 Breast cancer; CESC cis rs12586317 0.534 rs28384418 chr14:35452126 C/A cg05294307 chr14:35346193 BAZ1A -0.51 -6.31 -0.36 1.14e-9 Psoriasis; CESC cis rs7212590 0.618 rs59767604 chr17:58041339 C/G cg20303301 chr17:57937339 TUBD1 -0.54 -5.49 -0.32 9.55e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs7666738 0.830 rs2114426 chr4:98933130 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC cis rs926938 0.527 rs360580 chr1:115462334 A/G cg12756093 chr1:115239321 AMPD1 0.45 6.28 0.36 1.41e-9 Autism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10151248 chr11:66639567 PC 0.46 6.07 0.35 4.3e-9 Fibrinogen levels; CESC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg18099408 chr3:52552593 STAB1 -0.31 -5.16 -0.3 4.75e-7 Bipolar disorder; CESC cis rs6032067 0.929 rs13043296 chr20:43805688 T/C cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.5e-8 Blood protein levels; CESC cis rs8077889 0.917 rs8081646 chr17:41893360 T/C cg26893861 chr17:41843967 DUSP3 0.67 8.03 0.44 3.26e-14 Triglycerides; CESC cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6088580 0.634 rs4911422 chr20:32999345 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -6.99 -0.39 2.17e-11 Glomerular filtration rate (creatinine); CESC cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg10523679 chr1:76189770 ACADM 0.66 7.01 0.4 1.92e-11 Blood metabolite levels;Acylcarnitine levels; CESC trans rs1814175 0.647 rs10769646 chr11:49992204 C/A cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs5750830 0.594 rs9611165 chr22:39775250 A/G cg01416388 chr22:39784598 NA -0.54 -7.15 -0.4 8.7e-12 Intelligence (multi-trait analysis); CESC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg21984481 chr17:79567631 NPLOC4 -0.35 -5.41 -0.32 1.43e-7 Eye color traits; CESC cis rs9303280 0.806 rs4795399 chr17:38061439 T/C cg20243544 chr17:37824526 PNMT 0.53 6.87 0.39 4.54e-11 Self-reported allergy; CESC cis rs1577917 1.000 rs7760207 chr6:86721700 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.03 -0.35 5.34e-9 Response to antipsychotic treatment; CESC cis rs826838 1.000 rs10880963 chr12:38748408 T/C cg26384229 chr12:38710491 ALG10B 0.84 14.74 0.67 2.59e-36 Heart rate; CESC trans rs7090925 0.959 rs2454060 chr10:8465041 T/A cg02275004 chr12:976007 WNK1;HSN2 0.47 6.06 0.35 4.73e-9 Systemic lupus erythematosus; CESC cis rs11785400 0.963 rs6990126 chr8:143728387 T/C cg10596483 chr8:143751796 JRK 0.41 5.36 0.31 1.78e-7 Schizophrenia; CESC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg04234412 chr22:24373322 LOC391322 -0.54 -7.66 -0.43 3.43e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs11871801 0.517 rs6963 chr17:40731597 A/T cg16308533 chr17:40838983 CNTNAP1 -0.42 -5.41 -0.32 1.39e-7 Crohn's disease; CESC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.91e-10 Bipolar disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00734800 chr3:50388182 TUSC4;CYB561D2 0.5 6.58 0.37 2.48e-10 Gut microbiota (bacterial taxa); CESC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg18876405 chr7:65276391 NA -0.55 -7.37 -0.41 2.17e-12 Aortic root size; CESC cis rs7216064 0.531 rs6504573 chr17:66015963 C/T cg07042672 chr17:66097459 LOC651250 -0.49 -6.3 -0.36 1.23e-9 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg04025307 chr7:1156635 C7orf50 0.58 10.18 0.53 9.28e-21 Longevity;Endometriosis; CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.64 -0.33 4.35e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3816788 0.837 rs6557640 chr8:21771731 A/T cg17168535 chr8:21777572 XPO7 0.63 9.48 0.5 1.55e-18 Lung cancer in ever smokers; CESC cis rs3092073 0.624 rs11906879 chr20:44591324 C/T cg00981651 chr20:44574847 PCIF1 -0.38 -5.65 -0.33 4.16e-8 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg23281280 chr6:28129359 ZNF389 0.59 8.07 0.44 2.52e-14 Depression; CESC cis rs25645 0.771 rs11078936 chr17:38197914 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.55 7.53 0.42 7.78e-13 Myeloid white cell count; CESC cis rs2985684 1.000 rs2985687 chr14:50100386 T/C cg02151108 chr14:50098012 C14orf104 -0.42 -5.48 -0.32 9.97e-8 Carotid intima media thickness; CESC cis rs6867032 1.000 rs4975796 chr5:2015520 A/T cg26168224 chr5:2018326 NA -0.99 -19.8 -0.77 3.57e-54 Gut microbiome composition (winter); CESC cis rs2251381 0.741 rs2735966 chr21:30538174 G/A cg08807101 chr21:30365312 RNF160 0.67 8.3 0.45 5.33e-15 Selective IgA deficiency; CESC cis rs889312 0.500 rs832577 chr5:56163787 G/A cg14703610 chr5:56206110 C5orf35 0.48 6.29 0.36 1.32e-9 Breast cancer;Breast cancer (early onset); CESC cis rs7274811 0.595 rs13045068 chr20:32133484 G/C cg21523528 chr20:32077966 CBFA2T2 0.63 7.25 0.41 4.68e-12 Height; CESC cis rs11785400 1.000 rs4266629 chr8:143736635 A/G cg10596483 chr8:143751796 JRK 0.43 5.68 0.33 3.47e-8 Schizophrenia; CESC trans rs12681287 0.547 rs66808088 chr8:87521212 C/T cg27317242 chr8:23145699 R3HCC1 -0.51 -6.08 -0.35 4.09e-9 Caudate activity during reward; CESC cis rs1008375 0.931 rs2098151 chr4:17577490 T/C cg16339924 chr4:17578868 LAP3 0.74 9.68 0.51 3.59e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3815700 1.000 rs10407204 chr19:33097353 C/T cg24916020 chr19:33096688 ANKRD27 0.59 5.87 0.34 1.28e-8 Eosinophilic esophagitis; CESC cis rs478304 0.514 rs75601653 chr11:65483370 C/G cg27068330 chr11:65405492 SIPA1 -0.48 -5.54 -0.32 7.15e-8 Acne (severe); CESC trans rs72681920 0.881 rs28364304 chr4:100206912 T/C cg22948791 chr15:71404101 CT62 -0.54 -6.14 -0.35 2.96e-9 Alcohol dependence; CESC cis rs4237845 0.837 rs7971877 chr12:58287630 T/G cg00677455 chr12:58241039 CTDSP2 0.42 5.3 0.31 2.39e-7 Intelligence (multi-trait analysis); CESC cis rs6752107 0.901 rs2289477 chr2:234160345 T/G cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.37 5.74 0.33 2.56e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg19774624 chr17:42201019 HDAC5 -0.9 -14.84 -0.67 1.09e-36 Total body bone mineral density; CESC cis rs10089 1.000 rs73337363 chr5:127483597 A/G cg19767477 chr5:127420684 SLC12A2 -0.39 -5.18 -0.3 4.42e-7 Ileal carcinoids; CESC cis rs920590 0.758 rs7010174 chr8:19661930 G/C cg17834443 chr8:19674713 INTS10 0.58 6.53 0.37 3.27e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs1707322 1.000 rs10890378 chr1:46410657 A/G cg03146154 chr1:46216737 IPP -0.72 -9.82 -0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1729951 0.575 rs361244 chr3:136697506 C/T cg25687071 chr3:136751404 NA 0.4 5.33 0.31 2.13e-7 Neuroticism; CESC cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg11764359 chr7:65958608 NA 0.6 7.18 0.4 7.06e-12 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25152312 chr3:195595803 TNK2 -0.59 -6.79 -0.38 7.18e-11 Gut microbiome composition (summer); CESC cis rs3762637 0.823 rs9849013 chr3:122250605 A/G cg24169773 chr3:122142474 KPNA1 -0.59 -6.85 -0.39 5.26e-11 LDL cholesterol levels; CESC cis rs9858542 0.953 rs1987628 chr3:49399259 G/A cg03060546 chr3:49711283 APEH -0.52 -5.96 -0.34 7.89e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs8067545 0.563 rs3850780 chr17:20181902 A/C cg13482628 chr17:19912719 NA -0.42 -5.62 -0.33 4.92e-8 Schizophrenia; CESC cis rs12541635 0.966 rs1603363 chr8:107031319 A/G cg10147462 chr8:107024639 NA 0.39 5.48 0.32 9.71e-8 Age of smoking initiation; CESC cis rs9581857 0.547 rs17753121 chr13:28052613 T/C cg01674679 chr13:27998804 GTF3A -0.65 -5.19 -0.3 4.24e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs6598955 0.640 rs4233460 chr1:26633387 A/G cg04990556 chr1:26633338 UBXN11 -0.79 -11.16 -0.57 5.72e-24 Obesity-related traits; CESC cis rs17826219 0.561 rs4085382 chr17:29071202 T/C cg13385521 chr17:29058706 SUZ12P 0.74 6.21 0.36 2.01e-9 Body mass index; CESC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg21535942 chr1:75199100 CRYZ;TYW3 0.44 5.86 0.34 1.4e-8 Resistin levels; CESC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.86e-17 Tonsillectomy; CESC cis rs703842 0.616 rs4760171 chr12:58225904 A/G cg00599273 chr12:58146742 CDK4 0.34 5.16 0.3 4.93e-7 Multiple sclerosis; CESC cis rs11750568 0.967 rs6879226 chr5:178513371 A/G cg10208897 chr5:178548229 ADAMTS2 0.39 5.45 0.32 1.15e-7 Height; CESC cis rs7586673 0.866 rs7579662 chr2:161915810 G/A cg21518248 chr2:162101506 NA 0.47 6.27 0.36 1.48e-9 Intelligence (multi-trait analysis); CESC trans rs561341 0.882 rs72825748 chr17:30367396 G/A cg20587970 chr11:113659929 NA -1.49 -19.4 -0.77 8.69e-53 Hip circumference adjusted for BMI; CESC cis rs7116495 0.609 rs10501408 chr11:71680590 C/T cg26138937 chr11:71823887 C11orf51 -1.35 -7.73 -0.43 2.22e-13 Severe influenza A (H1N1) infection; CESC trans rs5758511 0.731 rs5751186 chr22:42349710 G/A cg15080870 chr19:47770746 CCDC9 -0.5 -6.2 -0.36 2.15e-9 Birth weight; CESC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg02018176 chr4:1364513 KIAA1530 -0.56 -7.16 -0.4 8.01e-12 Longevity; CESC cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg02297831 chr4:17616191 MED28 0.56 7.03 0.4 1.77e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs60843830 1.000 rs3791220 chr2:227066 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.87 11.66 0.58 1.2e-25 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21890848 chr21:27107814 ATP5J;GABPA 0.53 6.6 0.38 2.18e-10 Gut microbiome composition (summer); CESC cis rs765787 0.530 rs12592055 chr15:45514477 C/T cg24006582 chr15:45444508 DUOX1 0.51 6.25 0.36 1.59e-9 Uric acid levels; CESC cis rs11583043 0.708 rs12734559 chr1:101563001 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 5.47 0.32 1.03e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs12148488 0.738 rs4886417 chr15:75330159 T/G cg14664628 chr15:75095509 CSK -0.47 -5.71 -0.33 2.97e-8 Caffeine consumption; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20682991 chr2:74981952 NA 0.45 6.1 0.35 3.64e-9 Fibrinogen levels; CESC cis rs634534 0.562 rs642293 chr11:65730217 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.48 6.51 0.37 3.72e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs910316 0.712 rs175015 chr14:75457075 A/C cg16144293 chr14:75469539 EIF2B2 0.41 5.46 0.32 1.11e-7 Height; CESC cis rs938554 0.735 rs11942223 chr4:9962765 T/C cg11266682 chr4:10021025 SLC2A9 -0.42 -5.61 -0.33 5.17e-8 Blood metabolite levels; CESC cis rs2456568 0.803 rs10831142 chr11:93640781 A/G cg26875233 chr11:93583750 C11orf90 0.31 5.34 0.31 2.03e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs1670533 0.932 rs6599276 chr4:1056827 T/C cg04106633 chr4:1044584 NA 0.41 5.21 0.3 3.86e-7 Recombination rate (females); CESC cis rs10876993 0.928 rs1678532 chr12:58055197 T/G cg18357645 chr12:58087776 OS9 0.6 9.29 0.5 6.03e-18 Celiac disease or Rheumatoid arthritis; CESC cis rs4782309 0.544 rs8060579 chr16:88751667 G/C cg27087555 chr16:88793112 FAM38A -1.03 -6.33 -0.36 1.04e-9 Hair color; CESC cis rs965469 0.895 rs6051729 chr20:3290615 A/G cg25506879 chr20:3388711 C20orf194 -0.55 -5.89 -0.34 1.14e-8 IFN-related cytopenia; CESC cis rs3026101 0.671 rs8077933 chr17:5299674 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05994294 chr4:1374658 KIAA1530 0.43 6.0 0.35 6.4e-9 Fibrinogen levels; CESC cis rs3733585 0.699 rs6449202 chr4:9974043 T/C cg00071950 chr4:10020882 SLC2A9 -0.69 -11.29 -0.57 2.13e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01484320 chr1:109757057 SARS -0.46 -6.11 -0.35 3.55e-9 Height; CESC cis rs2952156 0.920 rs1018246 chr17:37835240 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.12 -0.3 5.94e-7 Asthma; CESC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.58 0.37 2.49e-10 Prudent dietary pattern; CESC cis rs9916302 0.706 rs582176 chr17:37453999 T/C cg07936489 chr17:37558343 FBXL20 0.92 10.37 0.54 2.23e-21 Glomerular filtration rate (creatinine); CESC cis rs7520050 0.807 rs12025621 chr1:46228391 G/A cg03146154 chr1:46216737 IPP -0.5 -6.6 -0.38 2.2e-10 Red blood cell count;Reticulocyte count; CESC cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg12927641 chr6:109611667 NA -0.43 -6.71 -0.38 1.19e-10 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03774484 chr12:7079822 PHB2;EMG1 0.65 7.88 0.44 8.7e-14 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs35820085 chr7:65442758 C/T cg12463550 chr7:65579703 CRCP 0.69 5.5 0.32 9.16e-8 Diabetic kidney disease; CESC cis rs9584850 0.834 rs8481 chr13:99105395 G/A cg20750642 chr13:99100586 FARP1 -0.38 -5.78 -0.33 2.05e-8 Neuroticism; CESC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.62 0.33 4.81e-8 Bipolar disorder; CESC cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.55e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4950322 0.857 rs72693002 chr1:146829304 T/A cg22381352 chr1:146742008 CHD1L -0.44 -5.08 -0.3 7.24e-7 Protein quantitative trait loci; CESC cis rs478304 0.654 rs7947604 chr11:65442059 G/C cg27068330 chr11:65405492 SIPA1 -0.46 -5.51 -0.32 8.54e-8 Acne (severe); CESC cis rs2836633 0.894 rs55955614 chr21:40037330 T/G cg12884169 chr21:40033163 ERG 0.39 6.17 0.35 2.53e-9 Coronary artery disease; CESC cis rs9486719 1.000 rs3798295 chr6:97052164 C/T cg18709589 chr6:96969512 KIAA0776 -0.53 -5.74 -0.33 2.54e-8 Migraine;Coronary artery disease; CESC cis rs7091068 0.706 rs4919398 chr10:95429162 C/T cg20715218 chr10:95462985 C10orf4 0.56 5.11 0.3 6.24e-7 Urinary tract infection frequency; CESC cis rs8062405 1.000 rs62036620 chr16:28833097 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.84 -0.34 1.55e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs9650657 0.645 rs9969657 chr8:10515278 A/G cg15556689 chr8:8085844 FLJ10661 0.47 6.08 0.35 4.12e-9 Neuroticism; CESC cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg09060608 chr5:178986726 RUFY1 0.45 6.32 0.36 1.12e-9 Lung cancer; CESC cis rs6495122 0.699 rs1378942 chr15:75077367 A/C cg14664628 chr15:75095509 CSK 0.68 9.37 0.5 3.22e-18 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs854765 0.583 rs12603148 chr17:17865257 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.65 9.42 0.5 2.29e-18 Total body bone mineral density; CESC cis rs2760061 0.505 rs708109 chr1:228190657 C/T cg02753203 chr1:228287806 NA 0.79 11.5 0.58 4.28e-25 Diastolic blood pressure; CESC cis rs7666738 0.830 rs1111541 chr4:99033860 A/G cg17366294 chr4:99064904 C4orf37 -0.62 -8.83 -0.48 1.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1843834 0.539 rs12694643 chr2:225446603 A/G cg22455342 chr2:225449267 CUL3 0.67 9.12 0.49 1.92e-17 IgE levels in asthmatics (D.p. specific); CESC cis rs7680126 0.500 rs4697717 chr4:10149784 C/G cg00071950 chr4:10020882 SLC2A9 -0.6 -6.46 -0.37 5.1e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs763121 0.925 rs4821797 chr22:39016182 T/C cg06544989 chr22:39130855 UNC84B 0.52 9.62 0.51 5.64e-19 Menopause (age at onset); CESC cis rs7584330 0.744 rs72620822 chr2:238379582 C/T cg14458575 chr2:238380390 NA 0.92 12.91 0.62 6.71e-30 Prostate cancer; CESC cis rs11608355 0.597 rs7300290 chr12:109832545 T/G cg19025524 chr12:109796872 NA -0.54 -7.66 -0.43 3.45e-13 Neuroticism; CESC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg02569458 chr12:86230093 RASSF9 0.49 7.24 0.41 4.79e-12 Major depressive disorder; CESC cis rs2243480 1.000 rs34136756 chr7:65381256 A/G cg18252515 chr7:66147081 NA -1.06 -9.79 -0.52 1.67e-19 Diabetic kidney disease; CESC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg03934478 chr11:495069 RNH1 0.54 5.15 0.3 5.16e-7 Body mass index; CESC cis rs727505 0.607 rs66478705 chr7:124789211 C/G cg23710748 chr7:124431027 NA -0.4 -6.27 -0.36 1.44e-9 Lewy body disease; CESC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg13628971 chr7:2884303 GNA12 -0.61 -7.9 -0.44 7.35e-14 Height; CESC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg05255149 chr17:80675120 FN3KRP 0.43 5.13 0.3 5.54e-7 Breast cancer; CESC cis rs193541 0.632 rs34714850 chr5:122332695 A/G cg19412675 chr5:122181750 SNX24 -0.46 -5.38 -0.31 1.67e-7 Glucose homeostasis traits; CESC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.47 -5.6 -0.33 5.28e-8 Schizophrenia; CESC cis rs400736 0.602 rs4573544 chr1:8165247 C/T cg25007680 chr1:8021821 PARK7 -0.58 -7.75 -0.43 2.01e-13 Response to antidepressants and depression; CESC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg22520471 chr17:61851767 DDX42;CCDC47 0.91 13.7 0.64 1.19e-32 Prudent dietary pattern; CESC cis rs8017423 0.967 rs11849641 chr14:90727647 T/C cg14092571 chr14:90743983 NA -0.55 -8.17 -0.45 1.24e-14 Mortality in heart failure; CESC cis rs2197308 0.765 rs11182481 chr12:37926019 T/C cg26384229 chr12:38710491 ALG10B 0.7 10.15 0.53 1.14e-20 Morning vs. evening chronotype; CESC cis rs116095464 0.558 rs73024831 chr5:257192 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.28 0.31 2.76e-7 Breast cancer; CESC cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg22875332 chr1:76189707 ACADM -0.64 -7.57 -0.42 6.05e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6546537 1.000 rs17036866 chr2:69857711 T/C cg10773587 chr2:69614142 GFPT1 -0.61 -7.44 -0.42 1.37e-12 Serum thyroid-stimulating hormone levels; CESC cis rs344364 0.511 rs1742462 chr16:1946062 A/C cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.93 0.34 9.24e-9 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24834479 chr5:133702818 CDKL3 -0.47 -6.03 -0.35 5.45e-9 Fibrinogen levels; CESC cis rs73206853 0.764 rs56205958 chr12:111027361 G/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.57 0.32 6.37e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg19680485 chr15:31195859 MTMR15 0.48 5.89 0.34 1.15e-8 Huntington's disease progression; CESC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg09783858 chr11:65769428 EIF1AD;BANF1 0.53 6.37 0.36 8.31e-10 Breast cancer; CESC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.72 0.33 2.81e-8 Electroencephalogram traits; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg03330302 chr2:26468406 HADHA;HADHB -0.4 -6.41 -0.37 6.57e-10 Vertical cup-disc ratio; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05800758 chr8:101225800 SPAG1 -0.44 -6.39 -0.37 7.4e-10 Gambling; CESC cis rs1008375 1.000 rs114490726 chr4:17680898 T/C cg16339924 chr4:17578868 LAP3 0.49 6.16 0.35 2.65e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11407514 chr10:99094219 FRAT2 -0.47 -6.81 -0.39 6.59e-11 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12662555 chr3:57742520 SLMAP 0.58 6.1 0.35 3.75e-9 Gut microbiome composition (summer); CESC cis rs1801251 0.896 rs6719061 chr2:233695885 C/T cg08000102 chr2:233561755 GIGYF2 -0.73 -11.73 -0.58 6.91e-26 Coronary artery disease; CESC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg07157834 chr1:205819609 PM20D1 0.48 6.96 0.39 2.6e-11 Menarche (age at onset); CESC cis rs6089584 0.507 rs6061999 chr20:60637429 G/A cg24733560 chr20:60626293 TAF4 0.41 5.97 0.34 7.57e-9 Body mass index; CESC cis rs6570726 0.935 rs415590 chr6:145851244 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 2.03e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4253772 0.637 rs9627350 chr22:46663017 A/G cg24881330 chr22:46731750 TRMU 0.85 9.5 0.5 1.3e-18 LDL cholesterol;Cholesterol, total; CESC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg21770322 chr7:97807741 LMTK2 0.6 9.15 0.49 1.59e-17 Prostate cancer (SNP x SNP interaction); CESC trans rs7819412 0.540 rs2409725 chr8:11041661 T/C cg06636001 chr8:8085503 FLJ10661 -0.53 -6.11 -0.35 3.53e-9 Triglycerides; CESC cis rs4319547 0.688 rs10744287 chr12:123077485 T/A cg05707623 chr12:122985044 ZCCHC8 -0.43 -5.44 -0.32 1.24e-7 Body mass index; CESC cis rs9815354 1.000 rs7616844 chr3:41874343 A/G cg03022575 chr3:42003672 ULK4 0.45 5.26 0.31 2.97e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg00166722 chr3:10149974 C3orf24 0.53 6.19 0.36 2.32e-9 Alzheimer's disease; CESC cis rs7937682 0.961 rs11601674 chr11:111634354 C/T cg22437258 chr11:111473054 SIK2 0.6 6.59 0.38 2.3e-10 Primary sclerosing cholangitis; CESC cis rs4900538 0.855 rs12590993 chr14:102844064 A/G cg18135206 chr14:102964638 TECPR2 -0.73 -9.31 -0.5 5e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg04414720 chr1:150670196 GOLPH3L -0.37 -5.26 -0.31 3.01e-7 Tonsillectomy; CESC cis rs4237845 0.537 rs11172367 chr12:58272486 T/G cg04478727 chr12:58166393 METTL1;FAM119B 0.51 5.77 0.33 2.17e-8 Intelligence (multi-trait analysis); CESC cis rs854765 0.534 rs7207461 chr17:17949789 T/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.49 -6.16 -0.35 2.63e-9 Total body bone mineral density; CESC cis rs7662987 0.938 rs28730605 chr4:100001540 C/T cg13256891 chr4:100009986 ADH5 -0.82 -6.05 -0.35 4.83e-9 Smoking initiation; CESC cis rs5753618 0.607 rs5753621 chr22:31847647 T/C cg02404636 chr22:31891804 SFI1 0.39 5.23 0.31 3.49e-7 Colorectal cancer; CESC cis rs4253772 0.637 rs9627402 chr22:46702586 C/T cg24881330 chr22:46731750 TRMU 0.79 6.62 0.38 1.97e-10 LDL cholesterol;Cholesterol, total; CESC cis rs7267979 1.000 rs422424 chr20:25445446 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.57 0.73 2.33e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg03213289 chr20:61660250 NA 0.39 6.16 0.35 2.7e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2273669 0.667 rs10457185 chr6:109322477 G/C cg05315195 chr6:109294784 ARMC2 -0.66 -6.01 -0.35 6.04e-9 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25601229 chr1:109618810 TAF13 0.61 6.4 0.37 7.11e-10 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs2109522 chr4:17658645 T/A cg16339924 chr4:17578868 LAP3 0.55 6.93 0.39 3.22e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg09035930 chr12:129282057 SLC15A4 0.68 9.08 0.49 2.61e-17 Systemic lupus erythematosus; CESC cis rs2806561 0.765 rs679591 chr1:23499916 T/C cg12483005 chr1:23474871 LUZP1 0.39 6.21 0.36 2.05e-9 Height; CESC cis rs2072499 0.865 rs2758603 chr1:156198994 T/C cg24450063 chr1:156163899 SLC25A44 0.82 12.6 0.61 7.47e-29 Testicular germ cell tumor; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg06370812 chr3:195501042 MUC4 -0.46 -6.38 -0.36 7.77e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs59918340 0.728 rs10112337 chr8:142233573 A/G cg23750338 chr8:142222470 SLC45A4 -0.61 -9.46 -0.5 1.78e-18 Immature fraction of reticulocytes; CESC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg08888203 chr3:10149979 C3orf24 0.49 6.47 0.37 4.7e-10 Alzheimer's disease; CESC cis rs67478160 0.619 rs8018062 chr14:104281954 C/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.09 -0.4 1.21e-11 Schizophrenia; CESC cis rs62064224 0.714 rs4794915 chr17:30634363 A/G cg18200150 chr17:30822561 MYO1D -0.39 -5.31 -0.31 2.32e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00339687 chr1:161348895 NA -0.49 -6.58 -0.37 2.47e-10 Gut microbiome composition (summer); CESC cis rs1395 0.778 rs724311 chr2:27441645 A/G cg22903471 chr2:27725779 GCKR -0.41 -5.09 -0.3 6.92e-7 Blood metabolite levels; CESC cis rs2425143 1.000 rs7273668 chr20:34442731 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 7.86e-12 Blood protein levels; CESC trans rs6445797 0.632 rs11921326 chr3:56664322 C/A cg15444621 chr13:113611794 NA 0.34 6.1 0.35 3.64e-9 Gastritis; CESC cis rs1511802 0.666 rs28698123 chr4:187123189 C/T cg24794857 chr4:187113578 CYP4V2 0.45 5.94 0.34 9.1e-9 Blood protein levels; CESC cis rs829883 0.872 rs1641641 chr12:98896018 A/C cg25150519 chr12:98850993 NA 0.71 9.74 0.51 2.31e-19 Colorectal adenoma (advanced); CESC cis rs3796352 1.000 rs58660500 chr3:53086573 C/T cg12962167 chr3:53033115 SFMBT1 0.69 6.06 0.35 4.58e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg03609598 chr5:56110824 MAP3K1 -0.5 -5.42 -0.32 1.34e-7 Initial pursuit acceleration; CESC cis rs523522 0.962 rs9040 chr12:120900274 C/T cg12219531 chr12:120966889 COQ5 0.74 9.37 0.5 3.43e-18 High light scatter reticulocyte count; CESC cis rs1256061 0.630 rs1256030 chr14:64747170 A/G cg21174375 chr14:64681225 SYNE2 0.44 5.77 0.33 2.24e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2046867 0.862 rs62252362 chr3:72855218 A/G cg25664220 chr3:72788482 NA -0.41 -6.06 -0.35 4.56e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.67 7.63 0.42 4.23e-13 Age-related macular degeneration (geographic atrophy); CESC trans rs561341 0.663 rs72821936 chr17:30224068 C/G cg20587970 chr11:113659929 NA -0.61 -8.13 -0.45 1.69e-14 Hip circumference adjusted for BMI; CESC cis rs1348850 0.874 rs6742951 chr2:178340766 G/C cg22681709 chr2:178499509 PDE11A -0.44 -6.16 -0.35 2.67e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.88 0.52 8.23e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs1904096 0.506 rs114312933 chr4:95216802 C/T cg11021082 chr4:95130006 SMARCAD1 -0.67 -11.08 -0.56 1.05e-23 Type 2 diabetes; CESC cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg11742103 chr11:62369870 EML3;MTA2 0.49 7.87 0.44 8.81e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs4662834 0.798 rs12991269 chr2:129490984 G/T cg12497543 chr10:97515377 ENTPD1 -0.4 -6.63 -0.38 1.82e-10 Response to bleomycin (chromatid breaks); CESC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg02574844 chr11:5959923 NA -0.47 -7.33 -0.41 2.86e-12 DNA methylation (variation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22791904 chr19:14273676 LPHN1 -0.62 -6.54 -0.37 3.07e-10 Gut microbiome composition (summer); CESC cis rs1143633 0.579 rs4849132 chr2:113673471 G/A cg12858261 chr2:113808755 IL1F8 -0.42 -5.11 -0.3 6.05e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.27e-16 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07818830 chr12:76953439 OSBPL8 0.63 7.22 0.41 5.42e-12 Gut microbiome composition (summer); CESC cis rs3741798 1.000 rs17303178 chr12:12485351 G/A cg08615371 chr12:12503544 MANSC1 0.87 6.35 0.36 9.19e-10 Cerebrospinal fluid biomarker levels; CESC cis rs2204008 0.837 rs10876019 chr12:37985477 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.61 0.38 2.1e-10 Bladder cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05644321 chr20:20693493 RALGAPA2 -0.43 -6.01 -0.35 6.26e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg17372223 chr3:52568218 NT5DC2 0.42 6.41 0.37 6.55e-10 Electroencephalogram traits; CESC cis rs2073300 0.609 rs6137930 chr20:23376732 G/A cg12062639 chr20:23401060 NAPB 1.07 8.85 0.48 1.29e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1847202 0.762 rs13093504 chr3:72949855 T/C cg25664220 chr3:72788482 NA -0.38 -5.55 -0.32 7.03e-8 Motion sickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13932339 chr15:25684205 UBE3A 0.5 6.06 0.35 4.72e-9 Gut microbiome composition (summer); CESC cis rs80130819 0.748 rs10747531 chr12:48632280 A/G cg05342945 chr12:48394962 COL2A1 -0.48 -5.2 -0.3 4.07e-7 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22880820 chr9:35665522 C9orf100 -0.58 -6.39 -0.37 7.36e-10 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg23758822 chr17:41437982 NA 1.02 15.41 0.69 1.13e-38 Menopause (age at onset); CESC cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg05347473 chr6:146136440 FBXO30 -0.56 -7.23 -0.41 5.1e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9323205 0.911 rs60034431 chr14:51622437 C/A cg23942311 chr14:51606299 NA -0.45 -5.75 -0.33 2.5e-8 Cancer; CESC cis rs9915657 0.743 rs9894720 chr17:70097607 C/T cg09344028 chr17:70110421 NA 0.4 7.96 0.44 4.94e-14 Thyroid hormone levels; CESC cis rs7107174 1.000 rs2512538 chr11:77972461 T/G cg02023728 chr11:77925099 USP35 0.48 6.34 0.36 9.87e-10 Testicular germ cell tumor; CESC cis rs1707322 1.000 rs785517 chr1:46567535 A/T cg05343316 chr1:45956843 TESK2 -0.47 -5.52 -0.32 7.97e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27649522 chr12:12877729 APOLD1 -0.46 -6.85 -0.39 5.3e-11 Gambling; CESC cis rs2354432 0.882 rs11576360 chr1:146740576 G/A cg25205988 chr1:146714368 CHD1L 1.1 15.69 0.69 1.13e-39 Mitochondrial DNA levels; CESC cis rs2346177 0.542 rs13024414 chr2:46687062 G/A cg02822958 chr2:46747628 ATP6V1E2 0.45 5.63 0.33 4.53e-8 HDL cholesterol; CESC cis rs6952808 0.756 rs13234214 chr7:1878860 C/T cg04267008 chr7:1944627 MAD1L1 -0.5 -5.98 -0.34 7.07e-9 Bipolar disorder and schizophrenia; CESC cis rs8180040 0.903 rs11710013 chr3:47296921 T/C cg27129171 chr3:47204927 SETD2 0.66 9.56 0.51 8.61e-19 Colorectal cancer; CESC cis rs1018836 0.632 rs7017630 chr8:91482604 A/G cg16814680 chr8:91681699 NA -0.61 -8.36 -0.46 3.55e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg06494592 chr3:125709126 NA -0.49 -5.35 -0.31 1.92e-7 Blood pressure (smoking interaction); CESC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg05332525 chr7:65337924 VKORC1L1 -0.52 -6.42 -0.37 6.27e-10 Calcium levels; CESC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg09658497 chr7:2847517 GNA12 -0.44 -6.45 -0.37 5.31e-10 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08265551 chr1:151032119 CDC42SE1;MLLT11 -0.42 -6.07 -0.35 4.39e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs3780486 0.505 rs10813959 chr9:33166234 C/T cg20290983 chr6:43655470 MRPS18A -0.72 -11.13 -0.56 7.49e-24 IgG glycosylation; CESC cis rs2705520 0.744 rs1814052 chr3:112231907 C/T cg09473763 chr3:112282684 SLC35A5 -0.78 -6.1 -0.35 3.72e-9 Asthma (childhood onset); CESC cis rs2228479 0.850 rs62052711 chr16:89855100 C/A cg14709524 chr16:89940631 TCF25 0.94 7.06 0.4 1.5e-11 Skin colour saturation; CESC cis rs2304069 0.955 rs4288106 chr5:149394872 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.91 11.7 0.58 9.24e-26 HIV-1 control; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19161053 chr7:99036702 CPSF4;PTCD1 0.48 6.22 0.36 1.91e-9 Gut microbiota (bacterial taxa); CESC cis rs10463316 0.894 rs6579865 chr5:150762335 A/C cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC cis rs6665290 0.669 rs3768423 chr1:227177293 G/A cg10327440 chr1:227177885 CDC42BPA -1.12 -24.44 -0.83 7.56e-70 Myeloid white cell count; CESC cis rs796364 0.806 rs79156935 chr2:200913822 T/G cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC cis rs4835473 0.864 rs35888177 chr4:144888016 G/C cg25736465 chr4:144833511 NA 0.41 6.27 0.36 1.43e-9 Immature fraction of reticulocytes; CESC cis rs6667605 0.527 rs4422947 chr1:2539590 C/T cg18854424 chr1:2615690 NA 0.3 6.1 0.35 3.69e-9 Inflammatory bowel disease;Ulcerative colitis; CESC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg23172400 chr8:95962367 TP53INP1 -0.44 -9.04 -0.49 3.45e-17 Type 2 diabetes; CESC cis rs6500602 0.702 rs2270366 chr16:4558615 A/G cg08645402 chr16:4508243 NA -0.55 -9.0 -0.48 4.61e-17 Schizophrenia; CESC cis rs9291683 0.588 rs6844329 chr4:10018544 T/C cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.14e-46 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26367235 chr2:239997305 HDAC4 -0.51 -6.1 -0.35 3.69e-9 Gut microbiome composition (summer); CESC cis rs7116495 1.000 rs541022 chr11:71783056 G/A cg10381502 chr11:71823885 C11orf51 -0.58 -5.16 -0.3 4.85e-7 Severe influenza A (H1N1) infection; CESC cis rs870825 0.698 rs28412823 chr4:185638829 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC cis rs2932538 0.922 rs7535636 chr1:113101799 C/T cg22162597 chr1:113214053 CAPZA1 -0.53 -6.73 -0.38 1.04e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs4682868 0.552 rs6771233 chr3:42922697 G/T cg21365077 chr3:42922735 NA 0.41 5.3 0.31 2.49e-7 Monocyte percentage of white cells; CESC trans rs1814175 0.592 rs1794161 chr11:49898825 A/C cg15704280 chr7:45808275 SEPT13 -1.0 -18.78 -0.76 1.35e-50 Height; CESC cis rs2070488 0.804 rs13059256 chr3:38504315 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.8 12.69 0.61 3.72e-29 Electrocardiographic conduction measures; CESC cis rs4481887 0.927 rs4551626 chr1:248489128 G/T cg00666640 chr1:248458726 OR2T12 0.36 6.17 0.35 2.56e-9 Common traits (Other); CESC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg23281280 chr6:28129359 ZNF389 0.43 6.41 0.37 6.46e-10 Cardiac Troponin-T levels; CESC cis rs11864453 0.514 rs2269918 chr16:72134831 C/A cg16558253 chr16:72132732 DHX38 -0.54 -8.45 -0.46 1.93e-15 Fibrinogen levels; CESC cis rs2404602 0.692 rs12911174 chr15:77149943 G/A cg22467129 chr15:76604101 ETFA -0.34 -5.18 -0.3 4.47e-7 Blood metabolite levels; CESC cis rs11158198 0.738 rs910879 chr14:58571252 T/G cg15908186 chr14:58618357 C14orf37 0.35 5.28 0.31 2.68e-7 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs6842047 0.901 rs2102575 chr4:187131504 G/A cg23442198 chr4:187126114 CYP4V2 0.72 5.79 0.33 2.03e-8 Blood protein levels; CESC cis rs870825 0.860 rs72689295 chr4:185600930 T/C cg04058563 chr4:185651563 MLF1IP 0.57 5.29 0.31 2.54e-7 Blood protein levels; CESC cis rs2279817 0.820 rs11203440 chr1:18026352 A/G cg21791023 chr1:18019539 ARHGEF10L 0.6 8.57 0.47 8.54e-16 Neuroticism; CESC cis rs7659604 0.540 rs4833769 chr4:122672970 A/C cg19671926 chr4:122722719 EXOSC9 -0.53 -6.53 -0.37 3.4e-10 Type 2 diabetes; CESC cis rs11785693 0.862 rs62491168 chr8:4982290 A/T cg26367366 chr8:4980734 NA 0.92 8.42 0.46 2.33e-15 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs1707322 1.000 rs9803784 chr1:46401907 T/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg01448562 chr3:133502909 NA -0.56 -7.73 -0.43 2.21e-13 Iron status biomarkers; CESC trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21659725 chr3:3221576 CRBN 0.83 13.55 0.64 3.87e-32 Intelligence (multi-trait analysis); CESC cis rs67311347 1.000 rs4973878 chr3:40407565 C/T cg01475735 chr3:40494733 NA -0.4 -5.06 -0.3 7.78e-7 Renal cell carcinoma; CESC cis rs12586317 0.620 rs8021414 chr14:35581480 T/A cg16230307 chr14:35515116 FAM177A1 0.92 10.08 0.53 1.98e-20 Psoriasis; CESC cis rs9346455 0.554 rs9346457 chr6:72009302 A/T cg27238071 chr6:71998145 OGFRL1 0.65 6.21 0.36 2.02e-9 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs1545257 0.537 rs2249387 chr2:24649801 C/G cg06627628 chr2:24431161 ITSN2 0.5 6.02 0.35 5.8e-9 Sjögren's syndrome; CESC cis rs1005224 0.853 rs61980778 chr14:76151532 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 0.43 5.88 0.34 1.21e-8 Large artery stroke; CESC trans rs4335177 0.893 rs6477532 chr9:109364501 T/G cg12580783 chr12:49362475 WNT10B -0.32 -6.09 -0.35 3.94e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs1577917 0.771 rs10944133 chr6:86358984 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.53 -7.08 -0.4 1.33e-11 Response to antipsychotic treatment; CESC cis rs2777491 0.874 rs7161772 chr15:41611066 A/T cg02330683 chr15:41787940 ITPKA 0.46 6.69 0.38 1.35e-10 Ulcerative colitis; CESC cis rs9611519 0.558 rs8137906 chr22:41442566 A/G cg03806693 chr22:41940476 POLR3H -0.51 -6.04 -0.35 5.14e-9 Neuroticism; CESC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg17376030 chr22:41985996 PMM1 -0.56 -6.22 -0.36 1.92e-9 Vitiligo; CESC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.24 0.53 5.92e-21 Prudent dietary pattern; CESC cis rs933688 1.000 rs12656350 chr5:90751343 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.02 10.84 0.55 6.7e-23 Smoking behavior; CESC cis rs1691799 0.899 rs2951656 chr12:66732273 T/G cg16791601 chr12:66731901 HELB -0.62 -10.16 -0.53 1.1e-20 White blood cell count (basophil); CESC cis rs870825 0.860 rs72689284 chr4:185596680 A/G cg04058563 chr4:185651563 MLF1IP 0.57 5.29 0.31 2.54e-7 Blood protein levels; CESC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg05313129 chr8:58192883 C8orf71 -0.5 -5.05 -0.3 8.06e-7 Developmental language disorder (linguistic errors); CESC cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg22834771 chr12:69754056 YEATS4 -0.39 -5.24 -0.31 3.2e-7 Blood protein levels; CESC trans rs2867695 0.590 rs11727456 chr4:81181908 C/T cg02056280 chr3:178866391 PIK3CA -0.72 -6.17 -0.35 2.6e-9 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs11997175 0.967 rs60586868 chr8:33776585 A/G ch.8.33884649F chr8:33765107 NA 0.59 7.72 0.43 2.35e-13 Body mass index; CESC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.44 0.32 1.22e-7 Major depressive disorder; CESC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -7.44 -0.42 1.4e-12 Autism spectrum disorder or schizophrenia; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg17994379 chr17:43025264 KIF18B 0.46 6.06 0.35 4.74e-9 Weight; CESC trans rs9467711 0.790 rs13195402 chr6:26463575 G/T cg01620082 chr3:125678407 NA -0.79 -6.2 -0.36 2.13e-9 Autism spectrum disorder or schizophrenia; CESC cis rs67478160 0.595 rs1475007 chr14:104297147 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.14 -0.4 9.19e-12 Schizophrenia; CESC cis rs2832191 0.967 rs2251377 chr21:30530599 T/C cg08807101 chr21:30365312 RNF160 0.65 8.66 0.47 4.64e-16 Dental caries; CESC cis rs1062177 0.756 rs2915817 chr5:151115517 T/C cg12924095 chr5:151150029 G3BP1 -0.45 -5.74 -0.33 2.53e-8 Preschool internalizing problems; CESC cis rs2014572 0.967 rs8111977 chr19:57759158 T/A cg12963866 chr19:57752005 ZNF805 -0.47 -6.28 -0.36 1.38e-9 Hyperactive-impulsive symptoms; CESC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg04546413 chr19:29218101 NA 0.56 7.77 0.43 1.76e-13 Methadone dose in opioid dependence; CESC cis rs854765 0.718 rs6502629 chr17:17869642 A/G cg16928487 chr17:17741425 SREBF1 -0.56 -9.26 -0.49 7.4e-18 Total body bone mineral density; CESC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg09323728 chr8:95962352 TP53INP1 -0.45 -9.86 -0.52 9.98e-20 Type 2 diabetes; CESC cis rs3741151 0.773 rs73544729 chr11:73183418 G/T cg17517138 chr11:73019481 ARHGEF17 0.95 6.99 0.39 2.29e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7666738 0.830 rs35752787 chr4:98935202 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs208520 0.731 rs12206488 chr6:66999917 G/T cg07460842 chr6:66804631 NA 0.89 9.57 0.51 8.13e-19 Exhaled nitric oxide output; CESC cis rs7208859 0.673 rs61348930 chr17:29221763 C/T cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2425143 0.818 rs6060726 chr20:34555878 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.58 0.32 6e-8 Blood protein levels; CESC cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg11905131 chr22:24372483 LOC391322 0.64 8.02 0.44 3.51e-14 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg26769984 chr7:1090371 C7orf50 0.61 6.91 0.39 3.52e-11 Bronchopulmonary dysplasia; CESC cis rs12973672 0.812 rs113185571 chr19:35758929 C/T cg12095397 chr19:35769544 USF2 0.49 5.83 0.34 1.59e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2046867 0.818 rs7637138 chr3:72910886 A/G cg25664220 chr3:72788482 NA -0.44 -6.39 -0.37 7.45e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg06481639 chr22:41940642 POLR3H 0.6 5.92 0.34 9.88e-9 Vitiligo; CESC cis rs7914558 0.966 rs11191471 chr10:104702050 T/A cg15744005 chr10:104629667 AS3MT -0.35 -5.48 -0.32 9.69e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs11969893 0.737 rs1854483 chr6:101378117 G/A cg12253828 chr6:101329408 ASCC3 0.96 8.17 0.45 1.26e-14 Economic and political preferences (immigration/crime); CESC trans rs6084875 0.641 rs2025116 chr20:4724011 C/T cg10192164 chr16:30419175 ZNF771 -0.51 -6.18 -0.35 2.44e-9 Systemic lupus erythematosus; CESC cis rs7666738 0.688 rs35739409 chr4:98576934 C/T cg05340658 chr4:99064831 C4orf37 0.52 5.27 0.31 2.85e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10465746 0.967 rs5028806 chr1:84329295 G/A cg10977910 chr1:84465055 TTLL7 0.47 6.45 0.37 5.3e-10 Obesity-related traits; CESC cis rs7665939 0.932 rs66626876 chr4:190101569 T/G cg09826759 chr4:190284978 NA -0.72 -7.55 -0.42 6.96e-13 Amyotrophic lateral sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16148674 chr11:14380065 RRAS2 0.59 6.65 0.38 1.62e-10 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg00745463 chr17:30367425 LRRC37B -0.81 -7.35 -0.41 2.5e-12 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22703791 chr19:1479558 C19orf25 0.52 6.18 0.35 2.47e-9 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg19468946 chr17:37922297 IKZF3 0.41 5.27 0.31 2.87e-7 Glomerular filtration rate (creatinine); CESC cis rs3820068 0.603 rs72647128 chr1:15963908 T/C cg13390004 chr1:15929781 NA 0.37 5.9 0.34 1.11e-8 Systolic blood pressure; CESC cis rs17166499 0.803 rs73070145 chr7:12898313 T/C cg12945054 chr7:12841881 NA 0.47 5.07 0.3 7.54e-7 Bipolar disorder and schizophrenia; CESC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 7.37 0.41 2.17e-12 Height; CESC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg05776053 chr2:74358815 NA 0.4 5.13 0.3 5.5e-7 Gestational age at birth (maternal effect); CESC cis rs8114671 0.967 rs2069948 chr20:33762489 C/T cg24642439 chr20:33292090 TP53INP2 0.44 5.37 0.31 1.73e-7 Height; CESC cis rs28374715 0.532 rs11854632 chr15:41682094 A/G cg18705301 chr15:41695430 NDUFAF1 1.03 16.81 0.72 1.18e-43 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25291941 chr8:99129319 POP1;HRSP12 -0.47 -6.33 -0.36 1.05e-9 Fibrinogen levels; CESC cis rs9302635 0.513 rs12928732 chr16:72188683 C/T cg16558253 chr16:72132732 DHX38 -0.42 -5.08 -0.3 7.08e-7 Blood protein levels; CESC cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg21573476 chr21:45109991 RRP1B -0.45 -6.32 -0.36 1.13e-9 Mean corpuscular volume; CESC cis rs6964587 1.000 rs10235941 chr7:91587050 T/G cg17063962 chr7:91808500 NA 0.57 7.77 0.43 1.73e-13 Breast cancer; CESC cis rs6121246 0.657 rs74392247 chr20:30241737 C/T cg13852791 chr20:30311386 BCL2L1 0.83 7.43 0.42 1.53e-12 Mean corpuscular hemoglobin; CESC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.65 -7.29 -0.41 3.48e-12 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.7 11.04 0.56 1.49e-23 Personality dimensions; CESC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg22920501 chr2:26401640 FAM59B 0.91 10.33 0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs7914558 0.933 rs10883814 chr10:104737404 T/C cg08650961 chr10:104748594 CNNM2 0.32 5.11 0.3 6.27e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg13298116 chr11:62369859 EML3;MTA2 0.65 9.52 0.5 1.16e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs28374715 0.681 rs7165396 chr15:41586947 T/C cg02330683 chr15:41787940 ITPKA 0.47 5.65 0.33 4.21e-8 Ulcerative colitis; CESC cis rs3126085 0.877 rs7537633 chr1:152223333 T/G cg03465714 chr1:152285911 FLG -0.42 -5.16 -0.3 4.84e-7 Atopic dermatitis; CESC cis rs1256061 0.603 rs1256044 chr14:64734027 G/A cg23250157 chr14:64679961 SYNE2 0.53 7.64 0.42 4.09e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.09 -0.35 3.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11153891 chr13:21182994 IFT88 -0.57 -7.45 -0.42 1.32e-12 Gut microbiome composition (summer); CESC cis rs7727544 0.735 rs274568 chr5:131713578 C/T cg24060327 chr5:131705240 SLC22A5 0.68 9.13 0.49 1.81e-17 Blood metabolite levels; CESC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg11890956 chr21:40555474 PSMG1 0.97 16.55 0.71 1.01e-42 Cognitive function; CESC cis rs17818399 0.645 rs35870739 chr2:46784231 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.49 -5.33 -0.31 2.07e-7 Height; CESC cis rs6690583 0.623 rs7540706 chr1:85534645 A/G cg22153463 chr1:85462885 MCOLN2 -0.67 -6.6 -0.38 2.18e-10 Serum sulfate level; CESC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg26335602 chr6:28129616 ZNF389 0.53 6.82 0.39 6.19e-11 Depression; CESC cis rs8180040 0.701 rs12491473 chr3:46989904 G/A cg27129171 chr3:47204927 SETD2 -0.63 -8.95 -0.48 6.24e-17 Colorectal cancer; CESC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs6570726 0.935 rs384519 chr6:145846017 C/A cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.96e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2180341 0.574 rs13192350 chr6:127677762 G/T cg24812749 chr6:127587940 RNF146 0.59 7.91 0.44 7.16e-14 Breast cancer; CESC cis rs11718455 0.881 rs17076257 chr3:44006787 C/T cg08738300 chr3:44038990 NA 0.46 6.13 0.35 3.09e-9 Coronary artery disease; CESC cis rs796364 0.806 rs10445791 chr2:201078307 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -5.94 -0.34 8.97e-9 Schizophrenia; CESC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg24531977 chr5:56204891 C5orf35 -0.97 -12.89 -0.62 7.59e-30 Initial pursuit acceleration; CESC cis rs10200159 1.000 rs12616982 chr2:55874811 C/T cg13617705 chr2:55845095 SMEK2 0.75 5.17 0.3 4.61e-7 Vitiligo; CESC trans rs11098499 0.697 rs35280960 chr4:120257059 G/A cg25214090 chr10:38739885 LOC399744 0.62 8.45 0.46 1.99e-15 Corneal astigmatism; CESC cis rs472109 0.935 rs378825 chr11:9766932 A/G cg03108697 chr11:9732066 SWAP70 -0.35 -5.28 -0.31 2.76e-7 Coronary artery disease; CESC cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg03467027 chr4:99064603 C4orf37 0.45 5.61 0.33 4.97e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg03467027 chr4:99064603 C4orf37 0.48 5.97 0.34 7.41e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7980687 0.638 rs7299943 chr12:123593485 A/T cg19016782 chr12:123741754 C12orf65 -0.39 -5.24 -0.31 3.25e-7 Height;Educational attainment;Head circumference (infant); CESC cis rs4076764 0.958 rs12022261 chr1:163398422 A/G cg06092702 chr1:163392909 NA -0.41 -5.9 -0.34 1.13e-8 Motion sickness; CESC cis rs7937682 0.883 rs568038 chr11:111432161 A/C cg22437258 chr11:111473054 SIK2 -0.74 -9.32 -0.5 4.66e-18 Primary sclerosing cholangitis; CESC trans rs10832139 0.553 rs9705260 chr11:13954554 T/A cg11511669 chr12:131556214 GPR133 0.48 5.99 0.35 6.68e-9 P wave terminal force; CESC cis rs8077577 0.945 rs62073608 chr17:18071448 T/C cg16794390 chr17:18148240 FLII 0.39 5.17 0.3 4.65e-7 Obesity-related traits; CESC cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg15782153 chr7:917662 C7orf20 0.52 5.72 0.33 2.91e-8 Cerebrospinal P-tau181p levels; CESC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -7.01 -0.4 1.93e-11 Bipolar disorder; CESC cis rs6831352 0.918 rs34805407 chr4:100050786 C/A cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs2637266 0.967 rs7477607 chr10:78358768 G/T cg18941641 chr10:78392320 NA 0.42 7.91 0.44 7.15e-14 Pulmonary function; CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg24739457 chr1:205821442 NA 0.42 5.54 0.32 7.23e-8 Menarche (age at onset); CESC cis rs6032067 0.925 rs13042522 chr20:43829290 G/A cg11264863 chr20:43835661 SEMG1 0.49 5.37 0.31 1.73e-7 Blood protein levels; CESC cis rs7191700 0.511 rs8058983 chr16:11360849 A/G cg00044050 chr16:11439710 C16orf75 -0.44 -5.38 -0.31 1.67e-7 Multiple sclerosis; CESC cis rs924607 0.898 rs905193 chr5:635095 T/C cg09021430 chr5:549028 NA -0.39 -6.86 -0.39 4.95e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12830829 chr14:51707081 TMX1 -0.45 -6.32 -0.36 1.1e-9 Fibrinogen levels; CESC trans rs10506458 0.834 rs12426860 chr12:63387948 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -17.85 -0.74 2.4e-47 Hemostatic factors and hematological phenotypes; CESC cis rs10751667 0.621 rs10794351 chr11:946228 C/T cg20946044 chr11:1010712 AP2A2 -0.37 -5.08 -0.3 7.19e-7 Alzheimer's disease (late onset); CESC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg00166722 chr3:10149974 C3orf24 0.49 6.04 0.35 5.3e-9 Alzheimer's disease; CESC cis rs7589728 0.844 rs2363010 chr2:88496399 G/C cg04511125 chr2:88470314 THNSL2 0.55 5.24 0.31 3.21e-7 Plasma clusterin levels; CESC cis rs1797885 0.510 rs2442820 chr3:12599196 G/C cg26432171 chr3:12704882 RAF1 -0.42 -5.49 -0.32 9.57e-8 Immature fraction of reticulocytes; CESC cis rs9913156 0.793 rs9916135 chr17:4568115 A/C cg19197139 chr17:4613644 ARRB2 -0.92 -10.59 -0.55 4.42e-22 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20203915 chr3:187871836 LPP 0.53 6.23 0.36 1.88e-9 Gut microbiome composition (summer); CESC cis rs9976767 0.608 rs9784208 chr21:43824986 A/G cg23042151 chr21:43824109 UBASH3A -0.33 -6.17 -0.35 2.55e-9 Type 1 diabetes; CESC cis rs6580649 0.882 rs7133249 chr12:48456823 C/T cg05342945 chr12:48394962 COL2A1 0.5 5.85 0.34 1.47e-8 Lung cancer; CESC cis rs6964587 1.000 rs6970277 chr7:91680655 T/C cg17063962 chr7:91808500 NA 0.54 7.18 0.4 6.85e-12 Breast cancer; CESC cis rs2228479 0.850 rs117880578 chr16:89910230 C/G cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs6121246 0.909 rs6119729 chr20:30413163 A/G cg13852791 chr20:30311386 BCL2L1 -0.81 -8.19 -0.45 1.14e-14 Mean corpuscular hemoglobin; CESC trans rs2207136 0.708 rs2746646 chr6:50818239 T/C cg06522515 chr3:184090630 THPO -0.38 -6.46 -0.37 4.93e-10 Myopia; CESC cis rs854765 0.619 rs1101727 chr17:18016148 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.25 0.36 1.66e-9 Total body bone mineral density; CESC cis rs2835872 0.758 rs1787396 chr21:39036487 A/C cg06728970 chr21:39037746 KCNJ6 0.3 5.57 0.32 6.36e-8 Electroencephalographic traits in alcoholism; CESC cis rs10493773 0.609 rs11161664 chr1:86185379 C/T cg17807903 chr1:86174739 ZNHIT6 -0.43 -6.26 -0.36 1.54e-9 Urate levels in overweight individuals; CESC cis rs6991838 0.584 rs7841652 chr8:66518627 T/G cg13398993 chr8:66546079 ARMC1 -0.46 -5.65 -0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs9487051 0.714 rs9487058 chr6:109631060 A/C cg21918786 chr6:109611834 NA -0.39 -5.71 -0.33 3.06e-8 Reticulocyte fraction of red cells; CESC cis rs10484885 0.878 rs17506550 chr6:90508896 A/G cg13799429 chr6:90582589 CASP8AP2 -0.64 -6.11 -0.35 3.61e-9 QRS interval (sulfonylurea treatment interaction); CESC cis rs372883 0.600 rs1312254 chr21:30695401 A/G cg08807101 chr21:30365312 RNF160 -0.47 -5.38 -0.31 1.65e-7 Pancreatic cancer; CESC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg06481639 chr22:41940642 POLR3H 0.62 6.08 0.35 4.07e-9 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09110292 chr10:32217076 ARHGAP12 -0.47 -6.07 -0.35 4.43e-9 Fibrinogen levels; CESC cis rs7474896 0.537 rs2472149 chr10:38262196 A/C cg25427524 chr10:38739819 LOC399744 0.52 5.92 0.34 1.01e-8 Obesity (extreme); CESC cis rs9309473 0.950 rs11126412 chr2:73887634 A/T cg20560298 chr2:73613845 ALMS1 -0.58 -7.36 -0.41 2.36e-12 Metabolite levels; CESC cis rs9911578 0.835 rs10853006 chr17:56489076 G/A cg12560992 chr17:57184187 TRIM37 -0.89 -14.79 -0.67 1.74e-36 Intelligence (multi-trait analysis); CESC cis rs2273669 0.667 rs12196024 chr6:109302258 C/T cg05315195 chr6:109294784 ARMC2 -0.65 -6.18 -0.35 2.43e-9 Prostate cancer; CESC cis rs2637266 1.000 rs7476937 chr10:78357692 A/T cg18941641 chr10:78392320 NA 0.44 8.13 0.45 1.71e-14 Pulmonary function; CESC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg04025307 chr7:1156635 C7orf50 0.39 5.19 0.3 4.26e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9796 0.505 rs28665387 chr15:41532869 G/T cg20272979 chr15:41787780 ITPKA 0.38 5.58 0.32 5.81e-8 Menopause (age at onset); CESC cis rs7615952 0.932 rs11922218 chr3:125631289 C/T cg05084668 chr3:125655381 ALG1L -0.47 -5.54 -0.32 7.34e-8 Blood pressure (smoking interaction); CESC cis rs9287719 0.967 rs6432112 chr2:10744874 A/G cg02196655 chr2:10830764 NOL10 0.36 5.56 0.32 6.43e-8 Prostate cancer; CESC cis rs116095464 0.558 rs9312977 chr5:221916 G/C cg22857025 chr5:266934 NA -1.27 -18.89 -0.76 5.51e-51 Breast cancer; CESC cis rs8177179 0.967 rs4994582 chr3:133437566 G/C cg17775713 chr3:133465469 TF 0.31 5.46 0.32 1.07e-7 Iron status biomarkers (transferrin levels); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg26206990 chr15:63569719 APH1B 0.42 6.2 0.36 2.12e-9 Thyroid stimulating hormone; CESC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.99 9.1 0.49 2.2e-17 Platelet count; CESC cis rs28374715 0.578 rs72739630 chr15:41631064 G/A cg02330683 chr15:41787940 ITPKA 0.47 5.42 0.32 1.37e-7 Ulcerative colitis; CESC cis rs9611565 0.918 rs9611561 chr22:41757234 C/G cg06481639 chr22:41940642 POLR3H -0.69 -7.36 -0.41 2.32e-12 Vitiligo; CESC cis rs701145 0.556 rs357502 chr3:153955950 C/T cg16511985 chr3:153974050 SGEF 0.46 6.25 0.36 1.62e-9 Coronary artery disease; CESC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 9.59 0.51 6.99e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs55728055 0.661 rs62237773 chr22:31965054 A/G cg01338084 chr22:32026380 PISD 1.26 8.23 0.45 8.62e-15 Age-related hearing impairment; CESC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg02398342 chr17:80708632 TBCD;FN3K 0.46 5.53 0.32 7.8e-8 Glycated hemoglobin levels; CESC cis rs7267979 0.903 rs6107015 chr20:25216764 G/A cg08601574 chr20:25228251 PYGB 0.43 6.04 0.35 5.08e-9 Liver enzyme levels (alkaline phosphatase); CESC trans rs61931739 1.000 rs12305700 chr12:34036332 T/C cg26384229 chr12:38710491 ALG10B -0.46 -6.19 -0.36 2.28e-9 Morning vs. evening chronotype; CESC cis rs8114671 0.527 rs2253484 chr20:33405263 A/T cg07148914 chr20:33460835 GGT7 -0.43 -5.63 -0.33 4.69e-8 Height; CESC cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg06022373 chr22:39101656 GTPBP1 0.9 14.22 0.66 1.8e-34 Menopause (age at onset); CESC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg21784768 chr11:537496 LRRC56 -0.56 -5.05 -0.3 8.36e-7 Body mass index; CESC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 7.08 0.4 1.26e-11 Height; CESC cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.48 -5.45 -0.32 1.13e-7 Osteoporosis; CESC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg25405998 chr7:65216604 CCT6P1 0.45 5.35 0.31 1.92e-7 Aortic root size; CESC cis rs2455799 0.573 rs2455830 chr3:15749213 C/T cg16303742 chr3:15540471 COLQ -0.4 -6.21 -0.36 2.03e-9 Mean platelet volume; CESC cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg18230493 chr5:56204884 C5orf35 0.61 7.97 0.44 4.79e-14 Initial pursuit acceleration; CESC cis rs3820068 0.705 rs4646110 chr1:15817318 A/T cg18192808 chr1:15853278 DNAJC16 0.46 5.53 0.32 7.59e-8 Systolic blood pressure; CESC cis rs17376456 0.877 rs12153506 chr5:93360953 T/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.2 0.3 3.98e-7 Diabetic retinopathy; CESC cis rs79349575 0.783 rs4793995 chr17:47019399 A/C cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg05564831 chr3:52568323 NT5DC2 0.44 6.69 0.38 1.33e-10 Bipolar disorder; CESC cis rs35146811 0.771 rs6465762 chr7:99620554 G/A cg13334819 chr7:99746414 C7orf59 -0.45 -5.24 -0.31 3.34e-7 Coronary artery disease; CESC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg24549020 chr5:56110836 MAP3K1 0.66 7.6 0.42 5.18e-13 Initial pursuit acceleration; CESC cis rs11711311 0.911 rs34337798 chr3:113396704 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.69 8.88 0.48 1e-16 IgG glycosylation; CESC trans rs7824557 0.527 rs2736305 chr8:11237773 T/C cg15556689 chr8:8085844 FLJ10661 -0.48 -6.0 -0.35 6.55e-9 Retinal vascular caliber; CESC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg13393036 chr8:95962371 TP53INP1 -0.39 -7.24 -0.41 4.9e-12 Type 2 diabetes; CESC cis rs6500602 0.727 rs4238849 chr16:4538114 G/A cg08645402 chr16:4508243 NA 0.58 9.43 0.5 2.19e-18 Schizophrenia; CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg11905131 chr22:24372483 LOC391322 -0.8 -12.09 -0.6 4.4e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg07677032 chr17:61819896 STRADA 0.45 5.93 0.34 9.64e-9 Prudent dietary pattern; CESC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg18876405 chr7:65276391 NA -0.51 -6.82 -0.39 6.14e-11 Aortic root size; CESC cis rs5753618 0.509 rs5753500 chr22:31578879 A/G cg13145458 chr22:31556086 RNF185 0.45 5.07 0.3 7.58e-7 Colorectal cancer; CESC cis rs7940866 0.903 rs11222421 chr11:130872351 A/T cg12179176 chr11:130786555 SNX19 0.65 9.49 0.5 1.39e-18 Schizophrenia; CESC cis rs2370759 1.000 rs77165999 chr10:32577131 T/C cg01819863 chr10:32635814 EPC1 1.16 13.25 0.63 4.48e-31 Sexual dysfunction (female); CESC cis rs137603 0.644 rs137621 chr22:39710244 G/A cg01093212 chr22:39715156 SNORD43;RPL3 -0.41 -5.31 -0.31 2.28e-7 Primary biliary cholangitis; CESC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg26939375 chr7:64535504 NA -0.74 -10.63 -0.55 3.13e-22 Aortic root size; CESC cis rs2455799 0.553 rs2262664 chr3:15768097 A/T cg16303742 chr3:15540471 COLQ -0.39 -6.24 -0.36 1.76e-9 Mean platelet volume; CESC cis rs4822044 0.560 rs7284839 chr22:42010902 C/T cg06634786 chr22:41940651 POLR3H 0.61 6.13 0.35 3.21e-9 Cannabis dependence symptom count; CESC cis rs10791097 0.592 rs7116068 chr11:130732739 A/C cg12179176 chr11:130786555 SNX19 -0.67 -9.91 -0.52 6.72e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg20608709 chr15:58889273 ADAM10 -0.47 -6.28 -0.36 1.36e-9 Gut microbiota (bacterial taxa); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04928513 chr20:60717545 PSMA7;SS18L1 -0.46 -6.32 -0.36 1.09e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07940793 chr17:79603854 NPLOC4 0.56 6.8 0.39 6.9e-11 Gut microbiome composition (summer); CESC cis rs7828089 0.504 rs12676477 chr8:22266425 T/C cg12081754 chr8:22256438 SLC39A14 0.6 8.26 0.45 6.86e-15 Verbal declarative memory; CESC cis rs3859192 0.561 rs12451547 chr17:38181168 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.6 8.95 0.48 6.49e-17 White blood cell count; CESC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg24060327 chr5:131705240 SLC22A5 -0.41 -5.15 -0.3 5.07e-7 Blood metabolite levels; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg23302558 chr2:182774636 SSFA2 0.39 6.24 0.36 1.69e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg27170947 chr2:26402098 FAM59B -0.58 -6.69 -0.38 1.3e-10 Gut microbiome composition (summer); CESC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg24549020 chr5:56110836 MAP3K1 -0.49 -5.87 -0.34 1.29e-8 Initial pursuit acceleration; CESC cis rs2439831 1.000 rs550239 chr15:43720197 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.61 0.55 3.7e-22 Lung cancer in ever smokers; CESC cis rs367943 0.666 rs10041899 chr5:112724742 A/T cg12552261 chr5:112820674 MCC 0.4 5.33 0.31 2.12e-7 Type 2 diabetes; CESC cis rs10876993 0.890 rs1082502 chr12:58035706 C/T cg18357645 chr12:58087776 OS9 0.58 9.07 0.49 2.73e-17 Celiac disease or Rheumatoid arthritis; CESC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 8.73 0.47 2.98e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg03609598 chr5:56110824 MAP3K1 -0.48 -5.22 -0.31 3.53e-7 Initial pursuit acceleration; CESC cis rs752010 0.695 rs10789407 chr1:42106538 G/T cg06885757 chr1:42089581 HIVEP3 0.49 7.81 0.43 1.37e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs6460942 0.591 rs62448726 chr7:12330881 A/G cg06484146 chr7:12443880 VWDE -0.66 -7.27 -0.41 4.01e-12 Coronary artery disease; CESC cis rs9470366 0.883 rs9462207 chr6:36627599 T/C cg08179530 chr6:36648295 CDKN1A 0.53 6.28 0.36 1.39e-9 QRS duration; CESC cis rs9291683 0.530 rs17246501 chr4:9985710 A/C cg02734326 chr4:10020555 SLC2A9 0.51 7.66 0.43 3.42e-13 Bone mineral density; CESC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg04369109 chr6:150039330 LATS1 -0.47 -6.56 -0.37 2.75e-10 Lung cancer; CESC cis rs897984 0.806 rs12924903 chr16:30928970 C/T cg02466173 chr16:30829666 NA -0.54 -9.34 -0.5 3.98e-18 Dementia with Lewy bodies; CESC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg11764359 chr7:65958608 NA -0.73 -10.43 -0.54 1.48e-21 Aortic root size; CESC cis rs6963495 0.818 rs73192105 chr7:105167945 T/C cg02135003 chr7:105160482 PUS7 -0.46 -5.45 -0.32 1.13e-7 Bipolar disorder (body mass index interaction); CESC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg11764359 chr7:65958608 NA -0.93 -14.62 -0.67 6.62e-36 Aortic root size; CESC cis rs1799949 0.965 rs4793234 chr17:41436183 A/G cg23758822 chr17:41437982 NA 1.03 16.1 0.7 3.99e-41 Menopause (age at onset); CESC cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg07636037 chr3:49044803 WDR6 1.02 18.44 0.75 2.06e-49 Parkinson's disease; CESC cis rs12142240 0.698 rs112068407 chr1:46822291 T/C cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg07677032 chr17:61819896 STRADA 0.45 5.93 0.34 9.64e-9 Prudent dietary pattern; CESC cis rs1707322 1.000 rs10890353 chr1:46298383 G/T cg03146154 chr1:46216737 IPP 0.72 9.83 0.52 1.2e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.87 0.34 1.28e-8 Tonsillectomy; CESC cis rs11677416 1.000 rs1304037 chr2:113532236 C/T cg27083787 chr2:113543245 IL1A -0.45 -5.77 -0.33 2.25e-8 Response to antipsychotic treatment in schizophrenia (working memory); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24986058 chr14:100812247 WARS -0.57 -6.24 -0.36 1.76e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg26408565 chr15:76604113 ETFA 0.4 5.62 0.33 4.94e-8 Blood metabolite levels; CESC cis rs9487051 0.676 rs4383852 chr6:109594475 G/A cg01475377 chr6:109611718 NA -0.44 -6.99 -0.39 2.19e-11 Reticulocyte fraction of red cells; CESC cis rs9640161 0.789 rs34311995 chr7:150059255 T/C cg17279839 chr7:150038598 RARRES2 0.42 5.49 0.32 9.44e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs6502050 0.749 rs7406163 chr17:80086389 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.13 0.3 5.62e-7 Life satisfaction; CESC cis rs4589502 0.800 rs2035150 chr15:67201794 A/C cg12317470 chr15:67143691 NA -0.71 -8.48 -0.46 1.65e-15 Lung cancer (smoking interaction); CESC cis rs7937682 0.564 rs9633937 chr11:111372799 C/T cg09085632 chr11:111637200 PPP2R1B 0.48 5.67 0.33 3.72e-8 Primary sclerosing cholangitis; CESC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg06028808 chr11:68637592 NA 0.43 5.12 0.3 5.87e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg04772025 chr11:68637568 NA 0.58 6.54 0.37 3.07e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs17376456 0.825 rs36042718 chr5:93180997 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 5.05 0.3 8.28e-7 Diabetic retinopathy; CESC cis rs748404 0.578 rs512628 chr15:43618734 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.9 0.44 7.7e-14 Lung cancer; CESC cis rs9929218 0.551 rs2274239 chr16:68725783 G/A cg02972257 chr16:68554789 NA -0.42 -5.26 -0.31 2.97e-7 Colorectal cancer; CESC cis rs2014572 0.933 rs8109882 chr19:57755618 C/G cg24459738 chr19:57751996 ZNF805 -0.54 -7.76 -0.43 1.84e-13 Hyperactive-impulsive symptoms; CESC cis rs10751667 0.961 rs6597953 chr11:991099 G/A cg06064525 chr11:970664 AP2A2 -0.42 -7.08 -0.4 1.27e-11 Alzheimer's disease (late onset); CESC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg06221963 chr1:154839813 KCNN3 -0.66 -11.39 -0.57 1.03e-24 Prostate cancer; CESC cis rs67311347 1.000 rs962847 chr3:40495156 A/G cg01475735 chr3:40494733 NA 0.47 5.94 0.34 8.79e-9 Renal cell carcinoma; CESC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg17724175 chr1:150552817 MCL1 0.39 5.95 0.34 8.56e-9 Melanoma; CESC cis rs727505 0.909 rs1031958 chr7:124627309 C/T cg23710748 chr7:124431027 NA -0.44 -6.86 -0.39 4.95e-11 Lewy body disease; CESC cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg00033643 chr7:134001901 SLC35B4 0.44 5.6 0.33 5.38e-8 Mean platelet volume; CESC trans rs208520 0.526 rs1385219 chr6:66754476 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 19.1 0.76 9.77e-52 Exhaled nitric oxide output; CESC cis rs644799 0.672 rs11021347 chr11:95653494 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.69 9.71 0.51 2.82e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11638352 1.000 rs11631340 chr15:44286325 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.53 -5.46 -0.32 1.09e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs10779751 1.000 rs11121704 chr1:11293959 A/G cg08854313 chr1:11322531 MTOR -0.78 -10.72 -0.55 1.63e-22 Body mass index; CESC cis rs7116495 0.867 rs4378421 chr11:71761996 T/C cg26138937 chr11:71823887 C11orf51 -1.33 -7.65 -0.43 3.76e-13 Severe influenza A (H1N1) infection; CESC cis rs708547 0.671 rs1718863 chr4:57887586 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.48 6.68 0.38 1.38e-10 Response to bleomycin (chromatid breaks); CESC cis rs611744 0.647 rs13280487 chr8:109270263 G/C cg21045802 chr8:109455806 TTC35 0.52 6.45 0.37 5.39e-10 Dupuytren's disease; CESC cis rs2040771 0.770 rs9605962 chr22:19233615 C/T cg02655711 chr22:19163373 SLC25A1 0.41 6.03 0.35 5.51e-9 Metabolite levels (small molecules and protein measures); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23262020 chr14:93651423 C14orf109;MOAP1 -0.48 -6.02 -0.35 5.91e-9 Ulcerative colitis; CESC cis rs854765 0.718 rs7224815 chr17:17845800 A/T cg09796270 chr17:17721594 SREBF1 0.43 5.81 0.34 1.75e-8 Total body bone mineral density; CESC cis rs2243480 1.000 rs313813 chr7:65503500 C/T cg18252515 chr7:66147081 NA -1.25 -12.25 -0.6 1.19e-27 Diabetic kidney disease; CESC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg18876405 chr7:65276391 NA -0.55 -7.28 -0.41 3.91e-12 Aortic root size; CESC cis rs7116495 0.609 rs4945392 chr11:71694645 C/T cg10381502 chr11:71823885 C11orf51 -1.19 -7.81 -0.43 1.32e-13 Severe influenza A (H1N1) infection; CESC cis rs644799 0.965 rs534488 chr11:95562327 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.27 0.66 1.19e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg12963246 chr6:28129442 ZNF389 0.41 6.05 0.35 5e-9 Cardiac Troponin-T levels; CESC cis rs9811920 0.581 rs793468 chr3:99538346 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.61 -9.88 -0.52 8.43e-20 Axial length; CESC cis rs77216612 0.835 rs56692845 chr12:12887811 C/T cg24098013 chr12:12878779 APOLD1 0.61 7.57 0.42 6.09e-13 Lymphocyte counts; CESC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs698813 0.789 rs2592195 chr2:44607707 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.82 0.34 1.73e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2658782 1.000 rs2605583 chr11:93164957 T/A cg15737290 chr11:93063684 CCDC67 0.55 7.02 0.4 1.86e-11 Pulmonary function decline; CESC cis rs6752107 0.782 rs12692254 chr2:234161211 A/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.38 5.91 0.34 1.04e-8 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09460159 chr17:30771470 PSMD11 0.65 7.91 0.44 6.86e-14 Gut microbiome composition (summer); CESC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg08736216 chr1:53307985 ZYG11A 0.43 7.25 0.41 4.64e-12 Monocyte count; CESC cis rs11252926 0.523 rs816596 chr10:548004 C/T cg03684893 chr10:554711 DIP2C -0.45 -6.91 -0.39 3.7e-11 Psychosis in Alzheimer's disease; CESC cis rs34779708 0.897 rs16935880 chr10:35415468 C/G cg04310649 chr10:35416472 CREM -0.51 -6.16 -0.35 2.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs7829975 0.714 rs4841040 chr8:8654527 T/C cg06636001 chr8:8085503 FLJ10661 0.49 6.38 0.36 8.08e-10 Mood instability; CESC cis rs10504229 0.953 rs114806125 chr8:58182416 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -8.73 -0.47 3e-16 Developmental language disorder (linguistic errors); CESC cis rs7267979 0.966 rs2261790 chr20:25262789 T/C cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg16680214 chr1:154839983 KCNN3 0.49 7.52 0.42 8.64e-13 Prostate cancer; CESC cis rs6701037 1.000 rs34493921 chr1:175122759 A/G cg00321850 chr1:175162397 KIAA0040 -0.42 -5.86 -0.34 1.37e-8 Alcohol dependence; CESC cis rs1881797 0.932 rs41305741 chr1:247689543 A/G cg11166453 chr1:247681781 NA 0.44 5.8 0.34 1.87e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs4450798 0.793 rs62234789 chr3:13750425 G/A cg23332027 chr3:13681764 NA 0.41 5.5 0.32 9.05e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg12463550 chr7:65579703 CRCP -0.6 -7.4 -0.41 1.78e-12 Aortic root size; CESC trans rs4843747 0.749 rs12102841 chr16:88072574 C/G cg26811252 chr16:29126840 RRN3P2 -0.68 -10.07 -0.53 2.03e-20 Menopause (age at onset); CESC cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg21138405 chr5:131827807 IRF1 0.54 9.32 0.5 4.74e-18 Asthma (sex interaction); CESC trans rs1814175 0.745 rs7483456 chr11:49774613 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.96 -0.77 1.02e-54 Height; CESC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg23281280 chr6:28129359 ZNF389 0.59 8.16 0.45 1.34e-14 Depression; CESC cis rs9309473 0.500 rs2421668 chr2:73885096 G/A cg20560298 chr2:73613845 ALMS1 0.51 7.18 0.4 7.15e-12 Metabolite levels; CESC cis rs10779751 0.734 rs12569242 chr1:11127511 A/C cg08854313 chr1:11322531 MTOR 0.76 10.11 0.53 1.61e-20 Body mass index; CESC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg13206674 chr6:150067644 NUP43 0.47 6.67 0.38 1.46e-10 Lung cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12108650 chr18:43678457 ATP5A1 0.49 6.35 0.36 9.34e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1538970 1.000 rs4660852 chr1:45848931 A/C cg05343316 chr1:45956843 TESK2 -0.83 -11.98 -0.59 1.02e-26 Platelet count; CESC cis rs7264396 0.635 rs6060710 chr20:34536055 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.6 7.36 0.41 2.35e-12 Total cholesterol levels; CESC cis rs11122272 0.735 rs2491405 chr1:231513431 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg02951883 chr7:2050386 MAD1L1 -0.41 -5.37 -0.31 1.69e-7 Bipolar disorder and schizophrenia; CESC cis rs1953600 0.540 rs2784773 chr10:81919800 A/G cg00277334 chr10:82204260 NA -0.54 -7.49 -0.42 1.06e-12 Sarcoidosis; CESC cis rs9291683 0.566 rs13144709 chr4:10044182 C/T cg02734326 chr4:10020555 SLC2A9 0.45 6.19 0.36 2.29e-9 Bone mineral density; CESC cis rs1018836 0.923 rs12680211 chr8:91633434 C/T cg16814680 chr8:91681699 NA -0.71 -10.18 -0.53 9e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg13206674 chr6:150067644 NUP43 0.43 5.98 0.34 7.33e-9 Lung cancer; CESC cis rs9682041 0.932 rs9841852 chr3:170067049 C/G cg11886554 chr3:170076028 SKIL 0.81 7.63 0.42 4.17e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs2735413 0.881 rs11150036 chr16:78075687 C/G cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7208859 0.623 rs9911997 chr17:29124648 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2197308 0.765 rs11182900 chr12:37934009 C/T cg26384229 chr12:38710491 ALG10B 0.75 11.19 0.57 4.49e-24 Morning vs. evening chronotype; CESC cis rs9457247 1.000 rs413232 chr6:167400972 G/A cg25258033 chr6:167368657 RNASET2 0.4 5.98 0.34 7.15e-9 Crohn's disease; CESC cis rs7193541 0.585 rs7978 chr16:74486189 T/C cg01733217 chr16:74700730 RFWD3 -0.91 -14.3 -0.66 9.39e-35 Multiple myeloma; CESC cis rs2191566 0.540 rs436739 chr19:44495553 A/G cg20607764 chr19:44506953 ZNF230 0.46 5.74 0.33 2.58e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg12648201 chr2:27665141 KRTCAP3 -0.32 -5.99 -0.35 6.8e-9 Total body bone mineral density; CESC cis rs2228479 0.618 rs72477006 chr16:89950299 G/C cg00800038 chr16:89945340 TCF25 -0.86 -7.47 -0.42 1.17e-12 Skin colour saturation; CESC cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg03433033 chr1:76189801 ACADM 0.68 8.14 0.45 1.54e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg17366294 chr4:99064904 C4orf37 0.54 7.1 0.4 1.11e-11 Colonoscopy-negative controls vs population controls; CESC cis rs7904368 0.806 rs7087360 chr10:16872337 C/A cg23933602 chr10:16859644 RSU1 0.6 5.74 0.33 2.58e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs7917772 0.502 rs2296584 chr10:104244323 T/A ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.25 0.31 3.06e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs11122272 0.735 rs2250734 chr1:231485958 G/A cg06096015 chr1:231504339 EGLN1 0.4 5.84 0.34 1.5e-8 Hemoglobin concentration; CESC cis rs4969178 0.965 rs4969186 chr17:76398404 C/G cg20026190 chr17:76395443 PGS1 0.48 7.72 0.43 2.33e-13 HDL cholesterol levels; CESC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.44 7.38 0.41 2.11e-12 Personality dimensions; CESC cis rs8099014 0.814 rs9966765 chr18:56116790 C/G cg19312305 chr18:56117016 MIR122 -0.28 -5.45 -0.32 1.15e-7 Platelet count; CESC cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg23649088 chr2:200775458 C2orf69 0.72 9.05 0.49 3.22e-17 Osteoporosis; CESC cis rs5769765 0.954 rs6009900 chr22:50236610 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.47 -5.31 -0.31 2.28e-7 Schizophrenia; CESC cis rs634534 0.622 rs1308733 chr11:65720841 T/C cg02427764 chr11:65769310 BANF1;EIF1AD -0.62 -8.22 -0.45 9.27e-15 Sum eosinophil basophil counts;Eosinophil counts; CESC trans rs7618501 0.573 rs7634917 chr3:50049299 T/G cg21659725 chr3:3221576 CRBN -0.52 -7.33 -0.41 2.83e-12 Intelligence (multi-trait analysis); CESC cis rs72781680 1.000 rs72781643 chr2:24208746 G/A cg08917208 chr2:24149416 ATAD2B 0.92 8.23 0.45 8.65e-15 Lymphocyte counts; CESC cis rs7193541 0.662 rs8052367 chr16:74658867 G/A cg01733217 chr16:74700730 RFWD3 1.08 21.41 0.8 1.02e-59 Multiple myeloma; CESC cis rs1044826 0.642 rs295481 chr3:139228811 C/T cg00490450 chr3:139108681 COPB2 0.45 5.53 0.32 7.84e-8 Obesity-related traits; CESC cis rs977987 0.836 rs7200053 chr16:75474618 C/T cg03315344 chr16:75512273 CHST6 0.43 6.11 0.35 3.46e-9 Dupuytren's disease; CESC cis rs9916302 0.904 rs10491128 chr17:37551988 G/A cg00129232 chr17:37814104 STARD3 0.53 6.59 0.38 2.35e-10 Glomerular filtration rate (creatinine); CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.18 0.4 7.14e-12 Bipolar disorder; CESC cis rs1348850 0.519 rs4144275 chr2:178523368 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.04 0.4 1.67e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs71277158 0.688 rs58417766 chr3:169833247 A/G cg04067573 chr3:169899625 PHC3 0.71 7.06 0.4 1.45e-11 Prostate cancer; CESC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg26116260 chr4:7069785 GRPEL1 0.92 11.99 0.59 9.37e-27 Monocyte percentage of white cells; CESC cis rs1348850 0.651 rs1901826 chr2:178225266 G/A cg23306229 chr2:178417860 TTC30B 0.54 6.85 0.39 5.2e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs12960505 0.506 rs6508235 chr18:51053941 A/G cg22196977 chr2:128263013 IWS1 -0.44 -6.11 -0.35 3.56e-9 Intelligence (multi-trait analysis); CESC cis rs6667605 0.527 rs4422947 chr1:2539590 C/T cg20673091 chr1:2541236 MMEL1 0.46 7.9 0.44 7.7e-14 Inflammatory bowel disease;Ulcerative colitis; CESC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg20887711 chr4:1340912 KIAA1530 0.55 7.84 0.43 1.08e-13 Longevity; CESC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg16145915 chr7:1198662 ZFAND2A -0.45 -6.31 -0.36 1.19e-9 Longevity;Endometriosis; CESC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg19482086 chr6:160211437 TCP1;MRPL18 -0.76 -10.85 -0.55 6.03e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs7107174 0.688 rs881361 chr11:78128047 C/G cg02023728 chr11:77925099 USP35 0.43 5.48 0.32 1.01e-7 Testicular germ cell tumor; CESC cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg12927641 chr6:109611667 NA -0.41 -6.43 -0.37 6e-10 Reticulocyte fraction of red cells; CESC cis rs3008870 0.959 rs1886686 chr1:67390468 C/G cg02640540 chr1:67518911 SLC35D1 0.5 5.3 0.31 2.47e-7 Lymphocyte percentage of white cells; CESC cis rs11122272 0.735 rs2790884 chr1:231531932 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg16278512 chr7:12443529 VWDE -0.45 -5.13 -0.3 5.62e-7 Coronary artery disease; CESC cis rs75477785 0.590 rs12354000 chr1:210107020 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.94 6.89 0.39 4.04e-11 Cleft lip with or without cleft palate; CESC cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg20135002 chr11:47629003 NA -0.39 -5.03 -0.3 9.04e-7 Subjective well-being; CESC cis rs2281558 0.917 rs3787080 chr20:25232604 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.57 7.38 0.41 2.02e-12 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs8002861 0.905 rs12429722 chr13:44412466 T/A cg19180546 chr13:44453867 C13orf31;CCDC122 -0.41 -5.18 -0.3 4.39e-7 Leprosy; CESC trans rs11098499 0.863 rs3775841 chr4:120425777 A/C cg25214090 chr10:38739885 LOC399744 0.73 9.99 0.52 3.68e-20 Corneal astigmatism; CESC cis rs9905704 0.624 rs34718875 chr17:57072461 G/A cg12560992 chr17:57184187 TRIM37 0.65 8.24 0.45 7.83e-15 Testicular germ cell tumor; CESC cis rs9581857 0.556 rs9581861 chr13:28039991 C/T cg01674679 chr13:27998804 GTF3A -0.55 -5.89 -0.34 1.17e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs4332037 0.901 rs11767040 chr7:1945468 C/T cg23422044 chr7:1970798 MAD1L1 -0.53 -5.37 -0.31 1.68e-7 Bipolar disorder; CESC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg06221963 chr1:154839813 KCNN3 -0.66 -11.44 -0.58 6.67e-25 Prostate cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17424859 chr6:71319002 NA -0.48 -6.64 -0.38 1.81e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6430585 0.640 rs3816155 chr2:136552526 A/C cg07169764 chr2:136633963 MCM6 -1.2 -17.51 -0.73 3.91e-46 Corneal structure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07970400 chr15:40650285 DISP2 0.6 7.15 0.4 8.56e-12 Gut microbiome composition (summer); CESC cis rs7116495 0.737 rs7101553 chr11:71753903 C/T cg26138937 chr11:71823887 C11orf51 -1.36 -8.5 -0.46 1.41e-15 Severe influenza A (H1N1) infection; CESC cis rs2415984 0.583 rs2642090 chr14:46968788 C/T cg14871534 chr14:47121158 RPL10L 0.34 5.21 0.31 3.73e-7 Number of children ever born; CESC cis rs344364 0.636 rs344363 chr16:1972548 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.56 -5.93 -0.34 9.56e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs2455799 0.613 rs6789076 chr3:15807725 A/T cg16303742 chr3:15540471 COLQ 0.37 5.94 0.34 8.86e-9 Mean platelet volume; CESC trans rs208520 0.690 rs1776365 chr6:66834474 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -12.94 -0.62 5.07e-30 Exhaled nitric oxide output; CESC cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg00677455 chr12:58241039 CTDSP2 0.52 6.55 0.37 3.04e-10 Multiple sclerosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03399598 chr4:174091002 GALNT7 0.51 6.91 0.39 3.54e-11 Gut microbiota (bacterial taxa); CESC cis rs7246657 0.943 rs1035479 chr19:37893300 G/T cg23950597 chr19:37808831 NA 0.54 5.91 0.34 1.03e-8 Coronary artery calcification; CESC cis rs4268898 0.527 rs72789910 chr2:24388609 T/G cg06627628 chr2:24431161 ITSN2 -0.99 -9.69 -0.51 3.3e-19 Asthma; CESC cis rs1062177 0.950 rs59580263 chr5:151269577 T/A cg12924095 chr5:151150029 G3BP1 0.43 5.32 0.31 2.2e-7 Preschool internalizing problems; CESC cis rs2425143 1.000 rs2425142 chr20:34350346 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.72 6.65 0.38 1.62e-10 Blood protein levels; CESC cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.38 -5.98 -0.34 7.37e-9 Personality dimensions; CESC cis rs9858542 1.000 rs11709525 chr3:49690496 C/T cg03060546 chr3:49711283 APEH -0.58 -6.84 -0.39 5.52e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7188697 0.922 rs173475 chr16:58580530 T/C cg21335942 chr16:58549945 SETD6 0.46 5.38 0.31 1.61e-7 QT interval; CESC cis rs67311347 0.911 rs58282210 chr3:40417943 C/T cg24209194 chr3:40518798 ZNF619 0.41 5.08 0.3 7.04e-7 Renal cell carcinoma; CESC cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg20307385 chr11:47447363 PSMC3 -0.6 -7.31 -0.41 3.23e-12 Subjective well-being; CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg04025307 chr7:1156635 C7orf50 0.53 8.9 0.48 9.07e-17 Longevity;Endometriosis; CESC cis rs668210 0.793 rs645571 chr11:65752852 A/T cg02202077 chr11:65769826 EIF1AD;BANF1 -0.61 -5.63 -0.33 4.58e-8 Cerebrospinal fluid biomarker levels; CESC cis rs9527 0.615 rs10883810 chr10:104727224 A/C cg04362960 chr10:104952993 NT5C2 0.42 5.28 0.31 2.7e-7 Arsenic metabolism; CESC cis rs7089973 0.624 rs11196940 chr10:116593791 T/G cg03647239 chr10:116582469 FAM160B1 0.44 5.37 0.31 1.71e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg11952622 chr19:58962976 ZNF324B 0.46 6.14 0.35 3.08e-9 Uric acid clearance; CESC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs644799 0.582 rs473157 chr11:95596874 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.46 5.95 0.34 8.5e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg05283184 chr6:79620031 NA -0.43 -6.62 -0.38 1.97e-10 Intelligence (multi-trait analysis); CESC cis rs796364 0.806 rs6743396 chr2:200860138 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.83 7.5 0.42 9.65e-13 Schizophrenia; CESC cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -5.13 -0.3 5.49e-7 Personality dimensions; CESC cis rs208520 0.802 rs208516 chr6:66946119 T/C cg07460842 chr6:66804631 NA -0.9 -10.84 -0.55 6.76e-23 Exhaled nitric oxide output; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19229622 chr11:47291485 MADD -0.43 -6.03 -0.35 5.41e-9 Gambling; CESC cis rs77106637 0.929 rs77464186 chr11:72460398 A/C cg03713592 chr11:72463424 ARAP1 1.3 11.1 0.56 9.07e-24 Type 2 diabetes; CESC cis rs910316 1.000 rs10140851 chr14:75512612 G/A cg11812906 chr14:75593930 NEK9 0.88 14.5 0.67 1.8e-35 Height; CESC cis rs4919694 1.000 rs77827514 chr10:104822009 C/T cg04362960 chr10:104952993 NT5C2 0.79 7.08 0.4 1.27e-11 Arsenic metabolism; CESC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg10645314 chr2:3704589 ALLC -0.46 -5.07 -0.3 7.62e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs523522 0.962 rs670568 chr12:121021206 C/T cg12219531 chr12:120966889 COQ5 0.76 10.07 0.53 2.15e-20 High light scatter reticulocyte count; CESC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.95 -0.52 5.06e-20 Developmental language disorder (linguistic errors); CESC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg04944784 chr2:26401820 FAM59B -0.64 -7.32 -0.41 3.04e-12 Gut microbiome composition (summer); CESC cis rs4319547 0.661 rs7398014 chr12:122943980 T/C cg05707623 chr12:122985044 ZCCHC8 -0.61 -7.0 -0.4 2.06e-11 Body mass index; CESC cis rs11723261 0.582 rs11733927 chr4:166828 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.44 5.57 0.32 6.39e-8 Immune response to smallpox vaccine (IL-6); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg01735503 chr16:69966815 MIR140;WWP2 0.46 7.06 0.4 1.42e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg21138405 chr5:131827807 IRF1 0.54 9.32 0.5 4.74e-18 Asthma (sex interaction); CESC cis rs921968 0.541 rs490483 chr2:219429052 A/T cg02176678 chr2:219576539 TTLL4 0.5 8.85 0.48 1.31e-16 Mean corpuscular hemoglobin concentration; CESC cis rs7818688 1.000 rs10097930 chr8:96025735 A/G cg16049864 chr8:95962084 TP53INP1 0.58 5.69 0.33 3.29e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs12579753 0.692 rs11115064 chr12:82278683 G/A cg23701643 chr12:82153290 PPFIA2 -0.36 -5.31 -0.31 2.36e-7 Resting heart rate; CESC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg12311346 chr5:56204834 C5orf35 -0.45 -5.61 -0.33 5.2e-8 Coronary artery disease; CESC cis rs317689 0.718 rs160827 chr12:69770147 G/A cg20891283 chr12:69753455 YEATS4 0.64 7.46 0.42 1.22e-12 Response to diuretic therapy; CESC cis rs910316 0.763 rs175435 chr14:75612025 A/G cg16144293 chr14:75469539 EIF2B2 -0.4 -5.25 -0.31 3.19e-7 Height; CESC trans rs7615952 0.611 rs35321002 chr3:125612065 G/C cg07211511 chr3:129823064 LOC729375 -0.87 -9.05 -0.49 3.1e-17 Blood pressure (smoking interaction); CESC cis rs727505 1.000 rs7791430 chr7:124429953 G/T cg23710748 chr7:124431027 NA -0.47 -7.62 -0.42 4.48e-13 Lewy body disease; CESC trans rs7945705 0.905 rs2568054 chr11:8876029 A/G cg10637292 chr12:52960529 KRT74 0.36 6.2 0.36 2.1e-9 Hemoglobin concentration; CESC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.3 -0.36 1.26e-9 Total body bone mineral density; CESC cis rs7429990 0.965 rs35012836 chr3:47711490 G/A cg11946769 chr3:48343235 NME6 0.53 5.32 0.31 2.22e-7 Educational attainment (years of education); CESC cis rs10493773 0.532 rs1889919 chr1:86180034 A/G cg17807903 chr1:86174739 ZNHIT6 -0.42 -6.38 -0.36 7.8e-10 Urate levels in overweight individuals; CESC trans rs1161397 1.000 rs280302 chr6:50622506 C/T cg15738089 chr13:44542704 NA -0.67 -6.01 -0.35 6.17e-9 Overweight status; CESC cis rs9814567 0.929 rs1863911 chr3:134205231 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.22 -0.36 1.92e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs965469 0.779 rs6139092 chr20:3334651 T/C cg17110299 chr20:3385021 C20orf194 0.43 5.6 0.33 5.48e-8 IFN-related cytopenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01999086 chr20:52824411 PFDN4 0.55 6.64 0.38 1.8e-10 Gut microbiome composition (summer); CESC cis rs4654899 0.865 rs12130664 chr1:21332812 G/T cg05370193 chr1:21551575 ECE1 0.43 6.55 0.37 3.03e-10 Superior frontal gyrus grey matter volume; CESC cis rs6662572 0.723 rs72677543 chr1:46565329 A/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.15 0.3 5.06e-7 Blood protein levels; CESC cis rs6775745 0.603 rs6792706 chr3:131783593 G/A cg12213930 chr3:131751605 CPNE4 0.48 5.46 0.32 1.08e-7 Neutrophil count; CESC cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6546550 0.743 rs6731941 chr2:70018496 A/G cg02498382 chr2:70120550 SNRNP27 -0.36 -6.14 -0.35 3e-9 Prevalent atrial fibrillation; CESC cis rs12477438 0.765 rs1115757 chr2:99660146 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg13880726 chr7:1868755 MAD1L1 0.54 7.25 0.41 4.45e-12 Bipolar disorder and schizophrenia; CESC cis rs7927592 0.763 rs3740628 chr11:68381415 A/G cg20283391 chr11:68216788 NA -0.43 -5.33 -0.31 2.14e-7 Total body bone mineral density; CESC cis rs9354308 0.840 rs17508021 chr6:66569748 G/A cg07460842 chr6:66804631 NA 0.68 7.68 0.43 3.08e-13 Metabolite levels; CESC cis rs7826238 0.720 rs12546760 chr8:8374836 A/G cg06636001 chr8:8085503 FLJ10661 -0.41 -5.04 -0.3 8.47e-7 Systolic blood pressure; CESC cis rs9815354 0.556 rs73073276 chr3:42025354 G/A cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs763121 0.925 rs17032 chr22:39130843 C/G cg14440974 chr22:39074834 NA -0.37 -5.3 -0.31 2.43e-7 Menopause (age at onset); CESC cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6831352 0.918 rs29001224 chr4:100047373 G/A cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC trans rs875971 0.508 rs10242423 chr7:66059175 A/G cg26939375 chr7:64535504 NA -0.53 -7.37 -0.41 2.22e-12 Aortic root size; CESC cis rs2073499 1.000 rs10510755 chr3:50281168 C/T cg05260129 chr3:50388622 TUSC4;CYB561D2 0.76 6.0 0.35 6.41e-9 Schizophrenia; CESC cis rs9831754 0.865 rs9842838 chr3:78387904 A/C cg06138941 chr3:78371609 NA -0.65 -7.71 -0.43 2.58e-13 Calcium levels; CESC trans rs3942852 0.806 rs11039515 chr11:48119474 A/G cg03929089 chr4:120376271 NA 0.57 6.45 0.37 5.27e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg24531977 chr5:56204891 C5orf35 0.91 11.41 0.57 8.39e-25 Initial pursuit acceleration; CESC trans rs7246657 0.943 rs6508732 chr19:38000468 C/T cg24637308 chr11:6592297 DNHD1 0.5 6.03 0.35 5.61e-9 Coronary artery calcification; CESC trans rs1728785 0.892 rs1617749 chr16:68580890 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.64 7.46 0.42 1.26e-12 Ulcerative colitis; CESC cis rs11711311 0.955 rs1048892 chr3:113464859 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.74 10.43 0.54 1.5e-21 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08805662 chr2:70369329 NA 0.6 7.25 0.41 4.63e-12 Gut microbiome composition (summer); CESC cis rs10887741 0.646 rs4244979 chr10:89425507 A/C cg13926569 chr10:89418898 PAPSS2 0.49 7.8 0.43 1.42e-13 Exercise (leisure time); CESC cis rs2304069 0.507 rs7728264 chr5:149394954 C/G cg12661370 chr5:149340060 SLC26A2 0.43 5.67 0.33 3.75e-8 HIV-1 control; CESC trans rs57221529 0.766 rs72703026 chr5:572383 G/A cg25482853 chr8:67687455 SGK3 1.12 10.77 0.55 1.11e-22 Lung disease severity in cystic fibrosis; CESC cis rs2243480 1.000 rs1723269 chr7:65472786 C/G cg13147721 chr7:65941812 NA -0.91 -8.73 -0.47 2.87e-16 Diabetic kidney disease; CESC cis rs75804782 0.521 rs72994970 chr2:239426992 G/A cg18131467 chr2:239335373 ASB1 -0.7 -5.37 -0.31 1.75e-7 Morning vs. evening chronotype;Chronotype; CESC trans rs11574514 1.000 rs8052287 chr16:67865073 C/T cg08619102 chr4:3765047 NA -0.71 -6.16 -0.35 2.73e-9 Crohn's disease; CESC cis rs660899 0.857 rs56009633 chr1:44231481 T/C cg19743044 chr1:44115203 KDM4A 0.42 5.17 0.3 4.68e-7 Hypertension risk in short sleep duration; CESC cis rs74781061 0.929 rs79600165 chr15:74940991 G/A cg17294928 chr15:75287854 SCAMP5 -0.48 -5.11 -0.3 6.14e-7 Endometriosis; CESC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg22920501 chr2:26401640 FAM59B -0.66 -7.67 -0.43 3.32e-13 Gut microbiome composition (summer); CESC trans rs1116547 0.600 rs2416281 chr5:112849823 C/T cg10115368 chr14:100435663 NA 0.52 6.13 0.35 3.21e-9 Cerebral amyloid angiopathy; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14443077 chr11:68606701 CPT1A -0.47 -6.02 -0.35 5.81e-9 Ulcerative colitis; CESC cis rs1256061 0.654 rs1256031 chr14:64746179 C/T cg21174375 chr14:64681225 SYNE2 0.39 5.08 0.3 7.05e-7 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs8005677 1.000 rs1956880 chr14:23394007 A/G cg01529538 chr14:23388837 RBM23 0.5 6.7 0.38 1.26e-10 Cognitive ability (multi-trait analysis); CESC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg21226059 chr5:178986404 RUFY1 0.4 5.82 0.34 1.65e-8 Lung cancer; CESC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg02725872 chr8:58115012 NA -0.34 -5.32 -0.31 2.18e-7 Developmental language disorder (linguistic errors); CESC cis rs9354352 0.935 rs9345749 chr6:66699892 G/T cg07460842 chr6:66804631 NA -0.43 -5.31 -0.31 2.34e-7 Initial pursuit acceleration in psychotic disorders; CESC cis rs3540 0.920 rs7182658 chr15:91019248 A/T cg22089800 chr15:90895588 ZNF774 0.44 5.5 0.32 8.77e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs8114671 0.527 rs3736802 chr20:33604042 T/C cg06115741 chr20:33292138 TP53INP2 -0.44 -5.3 -0.31 2.41e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08109855 chr7:6144399 USP42 0.61 7.39 0.41 1.91e-12 Gut microbiome composition (summer); CESC cis rs72634258 0.842 rs7545745 chr1:8165667 T/A cg00042356 chr1:8021962 PARK7 -0.46 -5.03 -0.3 8.94e-7 Inflammatory bowel disease; CESC cis rs17253792 0.822 rs13379340 chr14:56050346 C/G cg01858014 chr14:56050164 KTN1 -0.92 -7.38 -0.41 2.06e-12 Putamen volume; CESC cis rs854765 0.547 rs9894138 chr17:17964345 G/A cg16928487 chr17:17741425 SREBF1 0.55 9.02 0.48 3.96e-17 Total body bone mineral density; CESC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg27170947 chr2:26402098 FAM59B -0.89 -10.78 -0.55 1.04e-22 Gut microbiome composition (summer); CESC cis rs4132509 0.744 rs12124113 chr1:243904366 A/G cg21452805 chr1:244014465 NA 0.61 7.29 0.41 3.56e-12 RR interval (heart rate); CESC cis rs863345 0.564 rs11264988 chr1:158466912 A/G cg12129480 chr1:158549410 OR10X1 -0.33 -6.46 -0.37 4.99e-10 Pneumococcal bacteremia; CESC cis rs6121246 0.559 rs6119652 chr20:30259445 C/G cg13852791 chr20:30311386 BCL2L1 0.81 10.53 0.54 6.68e-22 Mean corpuscular hemoglobin; CESC trans rs875971 0.660 rs3764903 chr7:66098482 G/A cg26939375 chr7:64535504 NA -0.61 -8.26 -0.45 6.95e-15 Aortic root size; CESC cis rs9487051 0.652 rs6568559 chr6:109592751 C/T cg01475377 chr6:109611718 NA -0.44 -6.99 -0.39 2.19e-11 Reticulocyte fraction of red cells; CESC cis rs9611565 0.569 rs188057 chr22:41822305 T/G cg03806693 chr22:41940476 POLR3H 1.2 14.5 0.67 1.86e-35 Vitiligo; CESC cis rs708547 0.581 rs13121027 chr4:57813369 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.45 5.46 0.32 1.07e-7 Response to bleomycin (chromatid breaks); CESC cis rs12681366 0.762 rs10109060 chr8:95377368 G/A cg13257157 chr8:95487014 RAD54B 0.38 5.2 0.3 4.01e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs62432291 0.681 rs439126 chr6:159656632 T/C cg14500486 chr6:159655392 FNDC1 -0.62 -6.36 -0.36 8.94e-10 Joint mobility (Beighton score); CESC cis rs1707322 0.721 rs4609469 chr1:46117185 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7772486 0.790 rs6924159 chr6:146267873 A/G cg23711669 chr6:146136114 FBXO30 -0.94 -13.66 -0.64 1.66e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs1577917 0.958 rs11756615 chr6:86679835 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.08 -0.35 4.29e-9 Response to antipsychotic treatment; CESC cis rs10489525 0.599 rs11102879 chr1:115603504 C/T cg12756093 chr1:115239321 AMPD1 -0.45 -5.4 -0.31 1.51e-7 Autism; CESC cis rs4919044 0.808 rs835256 chr10:94779550 C/T cg00487187 chr10:94451625 HHEX -0.45 -5.05 -0.3 8.21e-7 Coronary artery disease; CESC trans rs10435719 0.902 rs7014580 chr8:11803262 C/G cg15556689 chr8:8085844 FLJ10661 0.53 6.73 0.38 1.05e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs9611565 0.592 rs5758427 chr22:42099688 A/G cg06634786 chr22:41940651 POLR3H 0.66 6.76 0.38 8.7e-11 Vitiligo; CESC cis rs9858542 1.000 rs11130213 chr3:49712297 C/T cg03060546 chr3:49711283 APEH -0.57 -6.81 -0.39 6.44e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4780401 0.526 rs12929396 chr16:11774625 C/T cg01061890 chr16:11836724 TXNDC11 -0.4 -5.1 -0.3 6.58e-7 Rheumatoid arthritis; CESC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg19468946 chr17:37922297 IKZF3 0.41 5.26 0.31 3.02e-7 Glomerular filtration rate (creatinine); CESC cis rs10883723 0.810 rs2296582 chr10:104244139 G/T cg22532475 chr10:104410764 TRIM8 -0.35 -6.2 -0.36 2.14e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs4843747 0.636 rs11117358 chr16:88105053 T/A cg06915872 chr16:87998081 BANP 0.43 5.19 0.3 4.17e-7 Menopause (age at onset); CESC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg08736216 chr1:53307985 ZYG11A -0.4 -7.26 -0.41 4.22e-12 Monocyte count; CESC cis rs4423214 0.559 rs10898228 chr11:71228358 A/T cg05163923 chr11:71159392 DHCR7 -0.58 -6.26 -0.36 1.58e-9 Vitamin D levels; CESC cis rs3733585 0.605 rs4235355 chr4:10123078 C/A cg00071950 chr4:10020882 SLC2A9 -0.65 -10.21 -0.53 7.69e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1018836 0.828 rs12547016 chr8:91563847 T/C cg16814680 chr8:91681699 NA -0.63 -9.25 -0.49 7.74e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9300255 0.830 rs28413626 chr12:123861452 G/A cg19016782 chr12:123741754 C12orf65 0.5 6.76 0.38 8.53e-11 Neutrophil percentage of white cells; CESC cis rs9611519 0.780 rs9611546 chr22:41698542 C/G cg17376030 chr22:41985996 PMM1 0.52 5.78 0.33 2.14e-8 Neuroticism; CESC cis rs9818758 0.607 rs67831908 chr3:49313513 T/G cg00383909 chr3:49044727 WDR6 0.81 6.16 0.35 2.63e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs7772486 0.875 rs865913 chr6:146308874 C/T cg23711669 chr6:146136114 FBXO30 0.9 13.1 0.63 1.45e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs3780486 0.846 rs10813950 chr9:33127640 A/G cg13443165 chr9:33130375 B4GALT1 -0.43 -6.02 -0.35 5.77e-9 IgG glycosylation; CESC cis rs72781680 0.752 rs56152044 chr2:23927680 A/G cg08917208 chr2:24149416 ATAD2B 1.05 9.35 0.5 3.89e-18 Lymphocyte counts; CESC trans rs747782 0.528 rs7937670 chr11:48313216 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.26 0.36 1.5e-9 Intraocular pressure; CESC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg27125505 chr17:43679177 LOC644172 -0.49 -6.94 -0.39 2.94e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs910316 1.000 rs10138183 chr14:75615227 T/C cg16144293 chr14:75469539 EIF2B2 -0.39 -5.07 -0.3 7.52e-7 Height; CESC cis rs1957429 0.808 rs1957436 chr14:65348207 T/G cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC cis rs5758511 0.514 rs5758586 chr22:42517471 A/T cg00645731 chr22:42541494 CYP2D7P1 0.63 9.78 0.52 1.69e-19 Birth weight; CESC cis rs916888 0.773 rs199445 chr17:44817408 C/T cg17911788 chr17:44343683 NA -0.61 -8.09 -0.44 2.19e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7826238 0.564 rs2921053 chr8:8319963 G/C cg15556689 chr8:8085844 FLJ10661 0.65 8.53 0.46 1.11e-15 Systolic blood pressure; CESC cis rs11122272 0.735 rs2009873 chr1:231499236 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.65 -0.43 3.62e-13 Hemoglobin concentration; CESC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.8 8.48 0.46 1.59e-15 Alzheimer's disease; CESC cis rs7937682 0.632 rs7112886 chr11:111743232 T/C cg22437258 chr11:111473054 SIK2 -0.48 -5.32 -0.31 2.2e-7 Primary sclerosing cholangitis; CESC cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg26818010 chr10:134567672 INPP5A -0.46 -5.77 -0.33 2.26e-8 Migraine; CESC cis rs10089 0.953 rs10223203 chr5:127527646 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.69 -9.07 -0.49 2.71e-17 Ileal carcinoids; CESC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg23161317 chr6:28129485 ZNF389 0.44 5.4 0.31 1.47e-7 Depression; CESC cis rs7607369 0.536 rs7600248 chr2:219665963 C/T cg02176678 chr2:219576539 TTLL4 -0.35 -6.21 -0.36 2.09e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg03934478 chr11:495069 RNH1 0.57 5.24 0.31 3.21e-7 Body mass index; CESC cis rs708547 0.581 rs781661 chr4:57780307 A/G cg25525207 chr4:57843836 C4orf14;POLR2B 0.43 5.12 0.3 5.97e-7 Response to bleomycin (chromatid breaks); CESC trans rs61931739 0.534 rs7313137 chr12:34010231 T/G cg26384229 chr12:38710491 ALG10B 0.59 8.21 0.45 9.45e-15 Morning vs. evening chronotype; CESC trans rs1814175 0.817 rs10128730 chr11:50023369 G/T cg15704280 chr7:45808275 SEPT13 -1.05 -21.18 -0.79 6.15e-59 Height; CESC cis rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07590406 chr3:58292066 RPP14 0.43 5.63 0.33 4.68e-8 Systemic lupus erythematosus; CESC cis rs7208859 0.623 rs9890862 chr17:29125450 C/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3820928 0.935 rs113195824 chr2:227769139 A/G cg05526886 chr2:227700861 RHBDD1 -0.44 -5.75 -0.33 2.41e-8 Pulmonary function; CESC cis rs12220238 0.596 rs11001083 chr10:76370949 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.55 5.12 0.3 5.85e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2370759 0.945 rs10508773 chr10:32575444 C/T cg01819863 chr10:32635814 EPC1 1.16 13.25 0.63 4.48e-31 Sexual dysfunction (female); CESC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg09658497 chr7:2847517 GNA12 -0.42 -5.92 -0.34 1e-8 Height; CESC cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg04455712 chr21:45112962 RRP1B 0.36 5.22 0.31 3.58e-7 Mean corpuscular volume; CESC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.33 0.41 2.84e-12 Prudent dietary pattern; CESC cis rs477692 0.692 rs12265758 chr10:131445144 A/G cg05714579 chr10:131428358 MGMT -0.6 -8.43 -0.46 2.31e-15 Response to temozolomide; CESC cis rs910316 1.000 rs175436 chr14:75608683 C/G cg11812906 chr14:75593930 NEK9 -0.88 -15.4 -0.69 1.18e-38 Height; CESC cis rs7017914 0.967 rs13271442 chr8:71585169 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.09 -0.3 6.93e-7 Bone mineral density; CESC cis rs11122272 0.735 rs2790883 chr1:231532726 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.62 -0.42 4.55e-13 Hemoglobin concentration; CESC trans rs4665809 1.000 rs750452 chr2:26324995 G/A cg09258813 chr8:37823409 ADRB3 -0.37 -6.08 -0.35 4.08e-9 Gut microbiome composition (summer); CESC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03934478 chr11:495069 RNH1 0.55 5.43 0.32 1.28e-7 Body mass index; CESC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg17178900 chr1:205818956 PM20D1 0.54 7.44 0.42 1.42e-12 Menarche (age at onset); CESC cis rs17376456 0.877 rs12716456 chr5:93397557 A/G cg21475434 chr5:93447410 FAM172A 0.77 6.93 0.39 3.23e-11 Diabetic retinopathy; CESC cis rs11098499 0.863 rs1480940 chr4:120457682 T/C cg09307838 chr4:120376055 NA 0.92 12.68 0.61 4.22e-29 Corneal astigmatism; CESC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg02935154 chr7:12443704 VWDE -0.61 -6.93 -0.39 3.11e-11 Coronary artery disease; CESC cis rs748404 0.578 rs4547312 chr15:43632138 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.58 7.4 0.41 1.77e-12 Lung cancer; CESC cis rs863345 0.547 rs10908675 chr1:158504129 A/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs9322193 0.884 rs9383865 chr6:150173179 A/G cg09699651 chr6:150184138 LRP11 0.51 6.43 0.37 5.91e-10 Lung cancer; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg02493798 chr17:6899577 ALOX12 -0.44 -7.82 -0.43 1.24e-13 Tonsillectomy; CESC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg18876405 chr7:65276391 NA 0.5 6.87 0.39 4.63e-11 Aortic root size; CESC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg11247378 chr22:39784982 NA -0.62 -9.06 -0.49 2.88e-17 Intelligence (multi-trait analysis); CESC cis rs67311347 1.000 rs9842564 chr3:40405810 A/G cg09455208 chr3:40491958 NA -0.43 -7.33 -0.41 2.86e-12 Renal cell carcinoma; CESC cis rs1865721 0.771 rs72975986 chr18:73127649 A/G cg26385618 chr18:73139727 C18orf62 -0.52 -8.29 -0.45 5.91e-15 Intelligence; CESC cis rs548181 0.611 rs2849225 chr11:125415936 A/G cg03464685 chr11:125439445 EI24 1.44 11.6 0.58 1.98e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4566357 0.595 rs2272203 chr2:227914655 C/G cg05526886 chr2:227700861 RHBDD1 -0.45 -6.02 -0.35 5.83e-9 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15605918 chr19:3501056 DOHH -0.61 -7.38 -0.41 2.04e-12 Gut microbiome composition (summer); CESC cis rs672059 1.000 rs479994 chr1:183161729 C/T ch.1.3577855R chr1:183094577 LAMC1 0.54 7.04 0.4 1.62e-11 Hypertriglyceridemia; CESC cis rs72634258 0.786 rs12563704 chr1:8033837 G/A cg00042356 chr1:8021962 PARK7 0.57 6.06 0.35 4.71e-9 Inflammatory bowel disease; CESC cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg05973401 chr12:123451056 ABCB9 0.58 7.36 0.41 2.32e-12 Platelet count; CESC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg05555928 chr11:63887634 MACROD1 0.38 5.61 0.33 5.07e-8 Platelet count; CESC cis rs9863 0.827 rs6488913 chr12:124445569 C/G cg00084347 chr12:124393913 DNAH10 -0.26 -5.08 -0.3 7.05e-7 White blood cell count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13446525 chr9:128170432 NA -0.43 -6.09 -0.35 4.04e-9 Ulcerative colitis; CESC cis rs4555082 0.830 rs3803319 chr14:105752458 G/A cg27165867 chr14:105738592 BRF1 -0.49 -5.17 -0.3 4.7e-7 Mean platelet volume;Platelet distribution width; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07867325 chr3:73159953 NA 0.48 6.92 0.39 3.34e-11 Fibrinogen levels; CESC cis rs9911578 0.835 rs2301867 chr17:56480074 T/A cg05425664 chr17:57184151 TRIM37 0.44 6.15 0.35 2.81e-9 Intelligence (multi-trait analysis); CESC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -12.12 -0.6 3.4e-27 Alzheimer's disease; CESC cis rs9287719 0.934 rs6721510 chr2:10751046 T/C cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs3771570 1.000 rs73018141 chr2:242221570 G/A cg21155796 chr2:242212141 HDLBP 0.64 5.35 0.31 1.95e-7 Prostate cancer; CESC cis rs7103648 1.000 rs7947450 chr11:47429904 G/A cg20307385 chr11:47447363 PSMC3 0.94 16.17 0.7 2.26e-41 Diastolic blood pressure;Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14798160 chr4:74718399 PF4V1 -0.56 -6.74 -0.38 1.01e-10 Gut microbiome composition (summer); CESC cis rs7107174 1.000 rs11601590 chr11:78073288 T/G cg02023728 chr11:77925099 USP35 0.38 5.34 0.31 2.05e-7 Testicular germ cell tumor; CESC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg05535760 chr7:792225 HEATR2 0.94 10.69 0.55 2.09e-22 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11489602 chr10:32345426 KIF5B 0.57 6.35 0.36 9.31e-10 Gut microbiome composition (summer); CESC cis rs56399783 0.901 rs6964740 chr7:2819656 C/G cg19731401 chr7:2775893 GNA12 0.66 6.0 0.35 6.41e-9 Childhood ear infection; CESC cis rs6460942 0.591 rs4721080 chr7:12337785 T/C cg20607287 chr7:12443886 VWDE -0.59 -6.52 -0.37 3.54e-10 Coronary artery disease; CESC trans rs73568641 0.546 rs1937637 chr6:154101847 G/A cg08374472 chr16:87445639 ZCCHC14 -0.46 -6.29 -0.36 1.28e-9 Methadone dose in opioid dependence; CESC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.22 0.36 1.9e-9 Menopause (age at onset); CESC cis rs752010 0.523 rs10890158 chr1:42117985 C/T cg06885757 chr1:42089581 HIVEP3 0.53 8.33 0.46 4.31e-15 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9393777 0.623 rs9358945 chr6:26472114 C/T cg12826209 chr6:26865740 GUSBL1 -0.68 -7.36 -0.41 2.32e-12 Intelligence (multi-trait analysis); CESC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg00166722 chr3:10149974 C3orf24 0.46 5.88 0.34 1.21e-8 Alzheimer's disease; CESC cis rs1465370 0.760 rs10263705 chr7:130027633 C/T cg04743876 chr7:130013617 NA -0.27 -5.09 -0.3 6.81e-7 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs7223966 1.000 rs11657081 chr17:61792339 C/T cg11494091 chr17:61959527 GH2 0.39 5.42 0.32 1.34e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6570726 0.935 rs398060 chr6:145841515 C/T cg23711669 chr6:146136114 FBXO30 -0.75 -10.84 -0.55 6.64e-23 Lobe attachment (rater-scored or self-reported); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg07243700 chr1:100731457 RTCD1 -0.47 -7.35 -0.41 2.44e-12 Vertical cup-disc ratio; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11906176 chr10:76970489 VDAC2 -0.49 -6.22 -0.36 1.93e-9 Ulcerative colitis; CESC cis rs79349575 0.783 rs62078370 chr17:47026836 G/C cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs1062177 1.000 rs2915878 chr5:151149662 A/G cg12924095 chr5:151150029 G3BP1 0.47 6.0 0.35 6.37e-9 Preschool internalizing problems; CESC trans rs11098499 0.604 rs34278750 chr4:120571136 G/A cg25214090 chr10:38739885 LOC399744 0.6 7.88 0.44 8.29e-14 Corneal astigmatism; CESC cis rs6728642 0.908 rs11901495 chr2:98017804 A/G cg26665480 chr2:98280029 ACTR1B 0.81 8.09 0.45 2.15e-14 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs2072732 0.861 rs12033927 chr1:2937550 A/G cg15211996 chr1:2936768 ACTRT2 0.35 5.29 0.31 2.53e-7 Plateletcrit; CESC cis rs2299587 0.689 rs1847154 chr8:17780338 A/G cg08627089 chr8:17753878 FGL1 -0.4 -5.27 -0.31 2.8e-7 Economic and political preferences; CESC cis rs731174 0.959 rs7527344 chr1:38191560 C/A cg12339802 chr1:38156545 C1orf109 -0.55 -6.33 -0.36 1.06e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7927771 0.832 rs935914 chr11:47387599 C/T cg20307385 chr11:47447363 PSMC3 0.53 6.28 0.36 1.38e-9 Subjective well-being; CESC cis rs1595825 0.891 rs58409972 chr2:198897061 A/T cg10820045 chr2:198174542 NA 0.42 5.15 0.3 5.04e-7 Ulcerative colitis; CESC cis rs7617773 0.780 rs11718350 chr3:48360992 T/G cg11946769 chr3:48343235 NME6 0.9 12.38 0.61 4.45e-28 Coronary artery disease; CESC trans rs17508449 0.865 rs113081027 chr1:114118802 C/G cg23028848 chr11:57092561 TNKS1BP1 -0.8 -6.16 -0.35 2.68e-9 Leprosy; CESC cis rs2832191 1.000 rs2832190 chr21:30488226 G/A cg24692254 chr21:30365293 RNF160 -0.73 -10.83 -0.55 6.97e-23 Dental caries; CESC cis rs459571 1.000 rs459571 chr9:136912626 C/T cg13789015 chr9:136890014 NCRNA00094 0.54 7.55 0.42 6.88e-13 Platelet distribution width; CESC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg18252515 chr7:66147081 NA 0.5 6.53 0.37 3.31e-10 Aortic root size; CESC cis rs11997175 0.646 rs28785323 chr8:33736104 C/G ch.8.33884649F chr8:33765107 NA 0.56 7.05 0.4 1.58e-11 Body mass index; CESC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg07936489 chr17:37558343 FBXL20 -0.81 -12.08 -0.6 4.67e-27 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15011941 chr7:75948230 NA -0.52 -6.18 -0.35 2.45e-9 Gut microbiome composition (summer); CESC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg08704250 chr15:31115839 NA 0.69 9.23 0.49 9.09e-18 Huntington's disease progression; CESC cis rs9948 1.000 rs72811629 chr2:97519901 T/G cg01990225 chr2:97406019 LMAN2L -0.68 -5.05 -0.3 8.28e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs10883723 0.810 rs2296581 chr10:104242886 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.8 -0.34 1.89e-8 Allergic disease (asthma, hay fever or eczema); CESC trans rs61931739 0.500 rs35391785 chr12:34444478 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.24 0.36 1.74e-9 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg11494091 chr17:61959527 GH2 0.73 12.76 0.62 2.2e-29 Prudent dietary pattern; CESC cis rs6963495 0.818 rs73190163 chr7:105157294 G/T cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs116095464 0.558 rs73024831 chr5:257192 A/G cg10591111 chr5:226296 SDHA -0.51 -6.15 -0.35 2.84e-9 Breast cancer; CESC cis rs60154123 0.772 rs701944 chr1:210417098 G/A cg23283495 chr1:209979779 IRF6 0.46 5.47 0.32 1.03e-7 Coronary artery disease; CESC cis rs10208940 0.920 rs6714976 chr2:68764873 G/T cg12452813 chr2:68675892 NA 0.51 5.11 0.3 6.17e-7 Urate levels in lean individuals; CESC cis rs4820539 0.966 rs2267001 chr22:23456696 T/C cg14186256 chr22:23484241 RTDR1 0.82 14.55 0.67 1.21e-35 Bone mineral density; CESC cis rs10242455 0.867 rs2687136 chr7:99325882 C/T cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs6582630 0.555 rs7301250 chr12:38596244 G/T cg26384229 chr12:38710491 ALG10B 0.73 10.91 0.56 4.06e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs4237845 0.611 rs10877036 chr12:58321650 A/G cg02175503 chr12:58329896 NA -0.88 -14.43 -0.66 3.18e-35 Intelligence (multi-trait analysis); CESC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg07090678 chr1:91966139 CDC7 0.41 5.53 0.32 7.68e-8 Breast cancer; CESC cis rs854765 0.547 rs2955356 chr17:17964717 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.6 -8.42 -0.46 2.43e-15 Total body bone mineral density; CESC cis rs34779708 0.966 rs12765038 chr10:35416513 G/C cg04310649 chr10:35416472 CREM -0.55 -6.8 -0.39 7.1e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs62283056 0.512 rs752854 chr4:6281961 C/T cg00701064 chr4:6280414 WFS1 0.65 9.21 0.49 1.01e-17 Cisplatin-induced ototoxicity; CESC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs9291683 0.510 rs4318649 chr4:10016815 T/C cg02734326 chr4:10020555 SLC2A9 0.42 5.76 0.33 2.3e-8 Bone mineral density; CESC cis rs10751667 0.580 rs10751664 chr11:927077 T/G cg06064525 chr11:970664 AP2A2 -0.52 -10.25 -0.53 5.74e-21 Alzheimer's disease (late onset); CESC cis rs7089973 0.523 rs34170154 chr10:116740959 C/T cg23260525 chr10:116636907 FAM160B1 0.3 5.24 0.31 3.21e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs11039389 1 rs11039389 chr11:47796062 T/C cg05585544 chr11:47624801 NA -0.49 -7.63 -0.42 4.21e-13 Neuroticism; CESC cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg11764359 chr7:65958608 NA 0.79 8.88 0.48 1.05e-16 Aortic root size; CESC cis rs6088580 0.634 rs6088478 chr20:32971719 T/C cg08999081 chr20:33150536 PIGU -0.66 -11.72 -0.58 8.03e-26 Glomerular filtration rate (creatinine); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08280159 chr8:145504568 BOP1 0.45 6.14 0.35 3.08e-9 Fibrinogen levels; CESC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg20887711 chr4:1340912 KIAA1530 -0.61 -8.28 -0.45 6.08e-15 Obesity-related traits; CESC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg13206674 chr6:150067644 NUP43 0.39 5.51 0.32 8.53e-8 Lung cancer; CESC cis rs7605827 0.930 rs4668904 chr2:15543642 C/G cg19274914 chr2:15703543 NA 0.31 5.52 0.32 8.05e-8 Educational attainment (years of education); CESC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.1 0.56 9.54e-24 Platelet count; CESC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.73 9.9 0.52 7.3e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1044826 0.642 rs6787649 chr3:139193321 C/T cg00490450 chr3:139108681 COPB2 0.43 5.33 0.31 2.11e-7 Obesity-related traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14653225 chr1:228003938 PRSS38 -0.41 -6.04 -0.35 5.06e-9 Gut microbiota (bacterial taxa); CESC cis rs7560272 0.669 rs13008860 chr2:73774019 G/A cg20560298 chr2:73613845 ALMS1 -0.39 -5.49 -0.32 9.3e-8 Schizophrenia; CESC cis rs1538970 0.962 rs9429076 chr1:45819489 A/G cg05343316 chr1:45956843 TESK2 0.74 9.43 0.5 2.09e-18 Platelet count; CESC trans rs11098499 0.722 rs10006192 chr4:120263022 T/C cg25214090 chr10:38739885 LOC399744 0.6 8.26 0.45 6.87e-15 Corneal astigmatism; CESC cis rs12142240 0.660 rs72885163 chr1:46807117 C/A cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC trans rs526821 0.595 rs565859 chr11:55297367 T/C cg15704280 chr7:45808275 SEPT13 -0.51 -6.28 -0.36 1.4e-9 Pediatric bone mineral density (spine); CESC cis rs11997175 0.522 rs10954930 chr8:33588352 C/T ch.8.33884649F chr8:33765107 NA 0.57 7.4 0.41 1.77e-12 Body mass index; CESC cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg22834771 chr12:69754056 YEATS4 -0.39 -5.26 -0.31 2.94e-7 Blood protein levels; CESC cis rs6674176 0.628 rs3828146 chr1:44428715 C/T cg12908607 chr1:44402522 ARTN -0.46 -6.61 -0.38 2.08e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs854765 0.583 rs8065563 chr17:17782404 A/G cg16928487 chr17:17741425 SREBF1 -0.6 -10.35 -0.54 2.67e-21 Total body bone mineral density; CESC cis rs9902453 0.967 rs4325622 chr17:28526475 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.68 0.43 3.18e-13 Coffee consumption (cups per day); CESC cis rs863345 0.584 rs10797023 chr1:158497079 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.78e-11 Pneumococcal bacteremia; CESC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg05368731 chr17:41323189 NBR1 0.56 7.59 0.42 5.62e-13 Menopause (age at onset); CESC cis rs2242663 0.798 rs1945302 chr11:66337498 C/T cg24851651 chr11:66362959 CCS 0.4 5.17 0.3 4.57e-7 Bipolar disorder; CESC cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg21918786 chr6:109611834 NA -0.4 -6.07 -0.35 4.5e-9 Reticulocyte fraction of red cells; CESC cis rs7520050 0.966 rs2486447 chr1:46545724 G/A cg24296786 chr1:45957014 TESK2 0.41 5.17 0.3 4.57e-7 Red blood cell count;Reticulocyte count; CESC cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg13298116 chr11:62369859 EML3;MTA2 0.65 9.65 0.51 4.56e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7116495 1.000 rs2511076 chr11:71783827 A/G cg26138937 chr11:71823887 C11orf51 -0.84 -6.79 -0.38 7.37e-11 Severe influenza A (H1N1) infection; CESC cis rs2273669 0.667 rs113477421 chr6:109310268 C/T cg05315195 chr6:109294784 ARMC2 -0.65 -5.94 -0.34 9.09e-9 Prostate cancer; CESC cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg18200150 chr17:30822561 MYO1D 0.64 10.73 0.55 1.51e-22 Schizophrenia; CESC cis rs4588572 0.643 rs9293747 chr5:77705567 A/G cg11547950 chr5:77652471 NA -0.46 -6.0 -0.35 6.55e-9 Triglycerides; CESC cis rs79349575 0.811 rs60708039 chr17:46999373 C/G cg26022315 chr17:47021804 SNF8 0.39 5.18 0.3 4.5e-7 Type 2 diabetes; CESC cis rs708547 0.957 rs2458552 chr4:57773442 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.67 7.33 0.41 2.78e-12 Response to bleomycin (chromatid breaks); CESC cis rs7927592 0.763 rs10896340 chr11:68312645 A/G cg01657329 chr11:68192670 LRP5 0.48 6.33 0.36 1.05e-9 Total body bone mineral density; CESC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.41 0.32 1.38e-7 Bipolar disorder; CESC cis rs7523050 0.643 rs7522324 chr1:109399644 T/C cg08274380 chr1:109419600 GPSM2 0.83 5.58 0.32 5.89e-8 Fat distribution (HIV); CESC cis rs113835537 0.529 rs11227499 chr11:66272824 A/G cg22134325 chr11:66188745 NPAS4 0.3 5.12 0.3 5.97e-7 Airway imaging phenotypes; CESC cis rs9913156 0.793 rs72835642 chr17:4573407 T/C cg19197139 chr17:4613644 ARRB2 0.94 10.57 0.54 4.94e-22 Lymphocyte counts; CESC cis rs7267979 0.934 rs113469203 chr20:25343258 G/A cg08601574 chr20:25228251 PYGB -0.38 -5.38 -0.31 1.62e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg08027265 chr7:2291960 NA -0.45 -6.93 -0.39 3.12e-11 Bipolar disorder and schizophrenia; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg20247781 chr1:113252666 PPM1J 0.4 6.13 0.35 3.16e-9 Thyroid stimulating hormone; CESC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.32 0.36 1.13e-9 Prudent dietary pattern; CESC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg18876405 chr7:65276391 NA 0.48 6.31 0.36 1.16e-9 Aortic root size; CESC cis rs9443189 0.570 rs9341532 chr6:76403674 A/G cg01950844 chr6:76311363 SENP6 0.88 9.29 0.5 6.05e-18 Prostate cancer; CESC trans rs8056446 0.710 rs8059793 chr16:78189298 A/C cg17371350 chr17:655677 ELP2P;GEMIN4 0.43 6.06 0.35 4.63e-9 Pulmonary function (smoking interaction); CESC cis rs7584330 0.666 rs72620816 chr2:238353604 C/T cg14458575 chr2:238380390 NA 0.84 10.63 0.55 3.16e-22 Prostate cancer; CESC cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg05340658 chr4:99064831 C4orf37 0.77 11.85 0.59 2.88e-26 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00196167 chr7:139026058 C7orf55 -0.47 -6.23 -0.36 1.81e-9 Ulcerative colitis; CESC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -12.98 -0.62 3.88e-30 Developmental language disorder (linguistic errors); CESC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg01097406 chr16:89675127 NA 0.38 5.41 0.32 1.42e-7 Vitiligo; CESC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.61 0.64 2.41e-32 Prudent dietary pattern; CESC cis rs72829446 0.530 rs17732878 chr17:7362359 C/T cg02795151 chr17:7402630 POLR2A -0.51 -5.45 -0.32 1.16e-7 Androgen levels; CESC cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg05340658 chr4:99064831 C4orf37 0.79 12.24 0.6 1.33e-27 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.69 0.33 3.38e-8 Personality dimensions; CESC cis rs2072732 0.861 rs12036378 chr1:2955158 G/A cg15211996 chr1:2936768 ACTRT2 0.34 6.04 0.35 5.27e-9 Plateletcrit; CESC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.44 -0.32 1.22e-7 Life satisfaction; CESC cis rs6840360 0.615 rs12503677 chr4:152610543 A/G cg22705602 chr4:152727874 NA -0.37 -5.18 -0.3 4.5e-7 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13172696 chr1:153951646 JTB -0.34 -6.21 -0.36 2.1e-9 Gambling; CESC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg18099408 chr3:52552593 STAB1 -0.32 -5.17 -0.3 4.69e-7 Bipolar disorder; CESC cis rs57506017 0.565 rs12699333 chr7:12269804 C/T cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.58e-7 Neuroticism; CESC cis rs6543140 0.964 rs4851010 chr2:103056127 A/T cg04239558 chr2:103089729 SLC9A4 -0.48 -6.07 -0.35 4.3e-9 Blood protein levels; CESC cis rs2204008 0.837 rs11611861 chr12:38357459 A/G cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.62e-9 Bladder cancer; CESC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg26338869 chr17:61819248 STRADA 0.69 9.2 0.49 1.12e-17 Prudent dietary pattern; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg19850565 chr19:35168394 ZNF302 0.44 6.04 0.35 5.29e-9 Weight; CESC cis rs4727027 0.866 rs10435245 chr7:148816081 C/G cg23158103 chr7:148848205 ZNF398 -0.41 -6.74 -0.38 9.9e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1670533 0.932 rs4690347 chr4:1057328 A/G cg27284194 chr4:1044797 NA 0.48 6.06 0.35 4.7e-9 Recombination rate (females); CESC cis rs1005277 0.522 rs289647 chr10:37968278 A/G cg25517755 chr10:38738941 LOC399744 -0.38 -5.05 -0.3 8.11e-7 Extrinsic epigenetic age acceleration; CESC cis rs2267137 0.843 rs570731 chr22:29758817 A/G cg07256473 chr22:29710276 RASL10A -0.42 -6.49 -0.37 4.21e-10 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs4974559 0.501 rs1250129 chr4:1254930 C/T cg20887711 chr4:1340912 KIAA1530 0.52 5.58 0.32 5.96e-8 Systolic blood pressure; CESC cis rs78456975 0.739 rs11896906 chr2:1519550 A/G cg01028140 chr2:1542097 TPO -0.47 -5.29 -0.31 2.56e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs72781680 0.800 rs6718635 chr2:24066183 A/C cg20701182 chr2:24300061 SF3B14 0.78 6.86 0.39 4.98e-11 Lymphocyte counts; CESC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.36 -0.31 1.82e-7 Life satisfaction; CESC cis rs459571 0.715 rs401826 chr9:136890591 C/T cg13789015 chr9:136890014 NCRNA00094 0.59 8.4 0.46 2.76e-15 Platelet distribution width; CESC cis rs72945132 0.678 rs35733235 chr11:70235595 C/T cg14191688 chr11:70257035 CTTN 0.41 5.12 0.3 5.9e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14806867 chr13:96329355 DNAJC3 0.55 6.21 0.36 2.04e-9 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg25072359 chr17:41440525 NA 0.5 6.77 0.38 8.41e-11 Menopause (age at onset); CESC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.06e-7 Aortic root size; CESC cis rs7666738 0.830 rs13115356 chr4:98933171 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7727544 0.684 rs274546 chr5:131699867 A/G cg24060327 chr5:131705240 SLC22A5 -0.6 -7.58 -0.42 5.85e-13 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06516150 chr12:109592528 ACACB 0.62 7.3 0.41 3.36e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23401212 chr20:1099146 PSMF1 0.62 6.8 0.39 6.93e-11 Gut microbiome composition (summer); CESC trans rs7307889 0.793 rs73047652 chr12:6015033 T/G cg18407955 chr7:158110685 PTPRN2 -0.71 -6.58 -0.37 2.48e-10 Obesity-related traits; CESC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg14820908 chr5:178986412 RUFY1 0.51 7.58 0.42 5.82e-13 Lung cancer; CESC cis rs4730250 0.707 rs257372 chr7:106796977 T/G cg02696742 chr7:106810147 HBP1 -0.55 -5.18 -0.3 4.44e-7 Osteoarthritis; CESC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.54 -0.37 3.08e-10 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08536481 chr12:123459152 ABCB9;OGFOD2 -0.43 -6.03 -0.35 5.43e-9 Fibrinogen levels; CESC cis rs2204008 0.546 rs11519978 chr12:37998170 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.87 0.56 5.15e-23 Bladder cancer; CESC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg25405998 chr7:65216604 CCT6P1 0.45 5.06 0.3 7.71e-7 Aortic root size; CESC cis rs2228479 0.867 rs2270459 chr16:89979851 A/C cg00800038 chr16:89945340 TCF25 0.73 7.17 0.4 7.68e-12 Skin colour saturation; CESC cis rs7191700 0.836 rs10163410 chr16:11430615 G/C cg00044050 chr16:11439710 C16orf75 0.49 5.65 0.33 4.03e-8 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22036008 chr5:122759586 CEP120 -0.52 -6.0 -0.35 6.52e-9 Gut microbiome composition (summer); CESC trans rs161857 0.536 rs257977 chr5:118802221 A/C cg02306526 chr12:2202821 CACNA1C 0.77 6.48 0.37 4.35e-10 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs7662987 0.517 rs2851277 chr4:100022910 G/T cg12011299 chr4:100065546 ADH4 0.6 6.6 0.38 2.23e-10 Smoking initiation; CESC cis rs72945132 0.941 rs66803755 chr11:70117473 G/A cg00319359 chr11:70116639 PPFIA1 0.78 7.42 0.41 1.56e-12 Coronary artery disease; CESC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.59 0.47 7.82e-16 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22194305 chr4:2264032 MXD4 0.48 6.07 0.35 4.37e-9 Gut microbiota (bacterial taxa); CESC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg03240473 chr21:43526662 UMODL1;C21orf128 -0.53 -7.13 -0.4 9.27e-12 IgG glycosylation; CESC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.42 -0.37 6.22e-10 Depression; CESC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg18446336 chr7:2847575 GNA12 -0.38 -5.72 -0.33 2.81e-8 Height; CESC cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 7.2 0.4 6.31e-12 Personality dimensions; CESC cis rs4849845 0.853 rs13386533 chr2:121029586 G/A cg24070213 chr2:121070622 NA 0.39 5.04 0.3 8.71e-7 Mean platelet volume; CESC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg04267008 chr7:1944627 MAD1L1 -0.61 -7.29 -0.41 3.67e-12 Schizophrenia; CESC cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg19748678 chr4:122722346 EXOSC9 0.8 10.05 0.53 2.39e-20 Type 2 diabetes; CESC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg23758822 chr17:41437982 NA 0.95 15.06 0.68 1.95e-37 Menopause (age at onset); CESC cis rs10089 1.000 rs4836369 chr5:127486462 A/G cg19767477 chr5:127420684 SLC12A2 -0.39 -5.18 -0.3 4.42e-7 Ileal carcinoids; CESC cis rs9815354 0.904 rs9848992 chr3:41875297 C/T cg03022575 chr3:42003672 ULK4 0.58 6.01 0.35 5.96e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs12791968 0.527 rs4755300 chr11:45013421 C/T cg11846598 chr11:44996168 LOC221122 0.55 6.14 0.35 2.99e-9 Inhibitory control; CESC cis rs941873 0.900 rs7092536 chr10:81131332 A/C cg08514558 chr10:81106712 PPIF 0.35 6.14 0.35 3.08e-9 Height; CESC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.3 0.31 2.46e-7 Menopause (age at onset); CESC cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg12365402 chr11:9010492 NRIP3 -0.47 -7.89 -0.44 7.93e-14 Hemoglobin concentration; CESC cis rs12824058 0.831 rs4759452 chr12:130812799 G/A cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs1144333 0.655 rs76532097 chr1:76320759 G/C cg22875332 chr1:76189707 ACADM 0.52 5.08 0.3 7.1e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs4835473 0.838 rs35800634 chr4:144656352 G/A cg25736465 chr4:144833511 NA -0.33 -5.3 -0.31 2.48e-7 Immature fraction of reticulocytes; CESC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg04287289 chr16:89883240 FANCA 0.64 8.66 0.47 4.66e-16 Vitiligo; CESC cis rs6502050 0.835 rs62078304 chr17:80085224 G/A cg23985595 chr17:80112537 CCDC57 0.42 6.53 0.37 3.27e-10 Life satisfaction; CESC cis rs6963495 0.745 rs73190169 chr7:105160500 A/G cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs2573652 1.000 rs2581343 chr15:100514418 C/G cg09918751 chr15:100517450 ADAMTS17 -0.39 -7.21 -0.4 5.96e-12 Height; CESC cis rs7264396 0.563 rs2425103 chr20:34312329 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.78 -0.55 1.03e-22 Total cholesterol levels; CESC cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 9.03 0.49 3.53e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8133932 0.727 rs2150453 chr21:47253215 C/T cg14185626 chr21:47401492 COL6A1 -0.46 -5.05 -0.3 8.06e-7 Schizophrenia; CESC cis rs6732160 0.588 rs2043100 chr2:73374096 T/C cg01422370 chr2:73384389 NA 0.57 9.1 0.49 2.21e-17 Intelligence (multi-trait analysis); CESC cis rs12476592 0.602 rs4671509 chr2:63686004 C/T cg17519650 chr2:63277830 OTX1 -0.47 -5.29 -0.31 2.52e-7 Childhood ear infection; CESC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg22800045 chr5:56110881 MAP3K1 0.82 9.74 0.51 2.29e-19 Initial pursuit acceleration; CESC cis rs7829975 0.777 rs560544 chr8:8637429 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -6.27 -0.36 1.48e-9 Mood instability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15560884 chr1:710097 NA -0.49 -6.43 -0.37 5.86e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs7605827 0.930 rs13024782 chr2:15700715 A/G cg19274914 chr2:15703543 NA 0.3 5.45 0.32 1.18e-7 Educational attainment (years of education); CESC cis rs11650494 0.831 rs8065389 chr17:47456064 G/T cg08112188 chr17:47440006 ZNF652 -0.99 -7.96 -0.44 5.02e-14 Prostate cancer; CESC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.93 10.32 0.54 3.22e-21 Platelet count; CESC cis rs1443512 0.812 rs2078098 chr12:54337527 C/A cg17410650 chr12:54324560 NA -0.47 -7.97 -0.44 4.79e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg02569458 chr12:86230093 RASSF9 0.51 7.54 0.42 7.64e-13 Major depressive disorder; CESC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg05872129 chr22:39784769 NA -0.85 -12.16 -0.6 2.47e-27 Intelligence (multi-trait analysis); CESC cis rs28374715 0.681 rs28687846 chr15:41599902 C/T cg02330683 chr15:41787940 ITPKA 0.49 5.84 0.34 1.51e-8 Ulcerative colitis; CESC cis rs2820292 0.678 rs4494199 chr1:201884668 C/T cg11586189 chr1:201857591 SHISA4 0.33 5.84 0.34 1.56e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs9300255 0.602 rs11057192 chr12:123693420 T/C cg05973401 chr12:123451056 ABCB9 0.49 5.63 0.33 4.63e-8 Neutrophil percentage of white cells; CESC cis rs7914558 1.000 rs11191539 chr10:104819770 A/G cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.49e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.01 0.56 1.89e-23 Platelet count; CESC trans rs9467711 0.606 rs9379901 chr6:26603866 T/C cg06606381 chr12:133084897 FBRSL1 -0.78 -7.41 -0.41 1.7e-12 Autism spectrum disorder or schizophrenia; CESC cis rs8067545 0.611 rs9893832 chr17:20038273 A/G cg13482628 chr17:19912719 NA 0.4 5.37 0.31 1.75e-7 Schizophrenia; CESC cis rs9399135 0.967 rs13191501 chr6:135366880 T/C cg24558204 chr6:135376177 HBS1L 0.5 6.85 0.39 5.16e-11 Red blood cell count; CESC cis rs892961 0.806 rs312910 chr17:75413961 A/C cg05865280 chr17:75406074 SEPT9 0.66 14.25 0.66 1.31e-34 Airflow obstruction; CESC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg00769240 chr8:12517080 NA -0.44 -6.01 -0.35 6.16e-9 Blood pressure (smoking interaction); CESC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg22903657 chr4:1355424 KIAA1530 -0.38 -5.18 -0.3 4.5e-7 Obesity-related traits; CESC cis rs7267979 1.000 rs2258617 chr20:25274318 C/T cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg17211192 chr8:82754475 SNX16 -0.7 -8.43 -0.46 2.27e-15 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21512817 chr2:216176813 ATIC 0.57 6.59 0.38 2.33e-10 Gut microbiome composition (summer); CESC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg10204951 chr7:910479 UNC84A -0.45 -5.64 -0.33 4.3e-8 Perceived unattractiveness to mosquitoes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15556090 chr7:149195153 ZNF746 0.41 6.33 0.36 1.02e-9 Gambling; CESC cis rs2380220 0.541 rs9285413 chr6:96023439 G/A cg15832292 chr6:96025679 MANEA 0.75 7.83 0.43 1.19e-13 Behavioural disinhibition (generation interaction); CESC cis rs2070488 0.775 rs6599211 chr3:38558830 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.78 -12.57 -0.61 9.53e-29 Electrocardiographic conduction measures; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09036558 chr16:69973001 WWP2 0.5 6.79 0.38 7.28e-11 Fibrinogen levels; CESC cis rs11696501 0.688 rs6104295 chr20:44326917 C/T cg11783356 chr20:44313418 WFDC10B -0.31 -5.08 -0.3 7.02e-7 Brain structure; CESC cis rs17764205 0.929 rs10419626 chr19:3256104 G/T cg04171554 chr19:2761892 SGTA -0.55 -5.15 -0.3 4.97e-7 Bipolar disorder and schizophrenia; CESC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg24060327 chr5:131705240 SLC22A5 -0.76 -10.74 -0.55 1.42e-22 Acylcarnitine levels; CESC cis rs1707322 0.835 rs946525 chr1:46487277 A/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.6 -0.33 5.27e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2120019 1.000 rs7162900 chr15:75368017 T/C cg09165964 chr15:75287851 SCAMP5 -0.67 -8.04 -0.44 3.09e-14 Blood trace element (Zn levels); CESC cis rs9837602 1.000 rs35521705 chr3:99716690 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 7.24 0.41 4.82e-12 Breast cancer; CESC cis rs7202877 0.656 rs247427 chr16:75439132 T/C cg04384234 chr16:75411784 CFDP1 0.5 5.78 0.33 2.09e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg09699651 chr6:150184138 LRP11 0.52 6.24 0.36 1.71e-9 Lung cancer; CESC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg26939375 chr7:64535504 NA 0.76 10.73 0.55 1.49e-22 Calcium levels; CESC cis rs1005277 0.522 rs7072977 chr10:37940440 C/A cg00409905 chr10:38381863 ZNF37A -0.49 -6.68 -0.38 1.4e-10 Extrinsic epigenetic age acceleration; CESC cis rs79839061 0.610 rs12651368 chr4:856787 G/A cg07828340 chr4:882639 GAK 1.09 8.38 0.46 3.15e-15 Intelligence (multi-trait analysis); CESC cis rs2573652 1.000 rs2581358 chr15:100513725 C/G cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.49 -0.32 9.64e-8 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13969496 chr9:140095465 C9orf75 -0.46 -6.34 -0.36 9.85e-10 Ulcerative colitis; CESC cis rs2191566 1.000 rs390369 chr19:44506984 C/T cg20607764 chr19:44506953 ZNF230 0.61 8.1 0.45 2e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs854765 0.583 rs8078105 chr17:17853782 T/C cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC cis rs7772486 0.875 rs2814863 chr6:146347299 C/T cg05347473 chr6:146136440 FBXO30 -0.45 -5.89 -0.34 1.15e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs25645 0.771 rs10445310 chr17:38205396 C/A cg17467752 chr17:38218738 THRA -0.53 -6.84 -0.39 5.47e-11 Myeloid white cell count; CESC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg23958373 chr8:599963 NA -0.91 -6.87 -0.39 4.68e-11 IgG glycosylation; CESC cis rs10927875 0.691 rs1048302 chr1:16340879 T/G cg22431228 chr1:16359049 CLCNKA -0.48 -7.86 -0.43 9.56e-14 Dilated cardiomyopathy; CESC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.3 0.63 2.96e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10504229 0.679 rs16921688 chr8:58054659 T/C cg02725872 chr8:58115012 NA -0.41 -5.95 -0.34 8.38e-9 Developmental language disorder (linguistic errors); CESC cis rs5769707 0.967 rs763126 chr22:49988574 G/T cg20744362 chr22:50050164 C22orf34 -0.41 -6.75 -0.38 9.28e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs763121 0.853 rs138713 chr22:39142615 T/C cg06022373 chr22:39101656 GTPBP1 0.92 16.53 0.71 1.2e-42 Menopause (age at onset); CESC cis rs6580649 0.883 rs7967762 chr12:48420214 C/T cg24011408 chr12:48396354 COL2A1 -0.42 -5.29 -0.31 2.6e-7 Lung cancer; CESC cis rs7605827 0.866 rs4668917 chr2:15661815 G/C cg19274914 chr2:15703543 NA 0.36 6.33 0.36 1.07e-9 Educational attainment (years of education); CESC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg03351412 chr1:154909251 PMVK 0.7 9.53 0.51 1.08e-18 Prostate cancer; CESC cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.05 0.35 4.95e-9 Colorectal cancer; CESC cis rs2637266 0.905 rs2395395 chr10:78360770 A/G cg18941641 chr10:78392320 NA 0.39 7.19 0.4 6.47e-12 Pulmonary function; CESC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 12.99 0.62 3.48e-30 Platelet count; CESC cis rs4332037 0.802 rs12113633 chr7:1932936 G/A cg23422044 chr7:1970798 MAD1L1 -0.58 -6.05 -0.35 5e-9 Bipolar disorder; CESC cis rs145445141 1 rs145445141 chr1:67489169 ATT/A cg08660285 chr1:67390436 MIER1;WDR78 0.92 10.71 0.55 1.8e-22 Neutrophil percentage of white cells; CESC cis rs2463822 0.764 rs7125402 chr11:62097259 C/T cg06239285 chr11:62104954 ASRGL1 0.89 8.97 0.48 5.69e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2066819 1.000 rs11575232 chr12:56744422 G/A cg26804944 chr12:56660921 COQ10A -0.83 -5.03 -0.3 9.17e-7 Psoriasis vulgaris; CESC cis rs7186908 0.761 rs34714490 chr16:72177099 G/T cg16558253 chr16:72132732 DHX38 -0.42 -5.15 -0.3 5.18e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2204008 0.597 rs4002591 chr12:38133841 A/G cg13010199 chr12:38710504 ALG10B 0.51 6.39 0.37 7.31e-10 Bladder cancer; CESC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg18252515 chr7:66147081 NA 0.46 6.03 0.35 5.53e-9 Aortic root size; CESC cis rs1665050 0.534 rs8028828 chr15:59236052 C/A cg05156742 chr15:59063176 FAM63B 0.5 6.42 0.37 6.18e-10 Atopic dermatitis; CESC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg10896456 chr17:42255109 ASB16;C17orf65 0.42 5.8 0.34 1.9e-8 Total body bone mineral density; CESC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg07701084 chr6:150067640 NUP43 0.47 6.62 0.38 1.97e-10 Lung cancer; CESC cis rs7127900 0.583 rs11043147 chr11:2234169 C/G cg25635251 chr11:2234043 NA 0.88 15.7 0.69 1.05e-39 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); CESC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg03709012 chr19:19516395 GATAD2A 0.96 14.18 0.66 2.35e-34 Tonsillectomy; CESC cis rs2204008 0.774 rs11616004 chr12:38278822 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.26 0.53 5.3e-21 Bladder cancer; CESC cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.48 6.19 0.36 2.33e-9 Colorectal cancer; CESC cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg02487422 chr3:49467188 NICN1 0.46 5.76 0.33 2.38e-8 Parkinson's disease; CESC cis rs116095464 0.558 rs9312956 chr5:201812 T/C cg22857025 chr5:266934 NA -1.27 -14.49 -0.66 2e-35 Breast cancer; CESC cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.54e-10 Blood protein levels; CESC cis rs1030268 0.640 rs12707092 chr7:133188145 C/G cg10665199 chr7:133106180 EXOC4 0.5 5.4 0.31 1.51e-7 Intelligence (multi-trait analysis); CESC cis rs11098499 0.863 rs11736416 chr4:120431661 C/T cg09307838 chr4:120376055 NA 0.93 12.81 0.62 1.5e-29 Corneal astigmatism; CESC cis rs1550582 0.662 rs4909628 chr8:135502380 A/T cg17885191 chr8:135476712 NA -0.84 -10.71 -0.55 1.8e-22 Educational attainment; CESC cis rs9291683 0.595 rs35250962 chr4:10048271 C/T cg00071950 chr4:10020882 SLC2A9 0.85 14.82 0.67 1.3e-36 Bone mineral density; CESC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.65 -9.11 -0.49 2.12e-17 Personality dimensions; CESC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg11764359 chr7:65958608 NA 0.67 8.72 0.47 3.12e-16 Aortic root size; CESC cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg20701182 chr2:24300061 SF3B14 0.94 10.42 0.54 1.55e-21 Lymphocyte counts; CESC trans rs66573146 0.831 rs66645969 chr4:6985614 G/A cg07817883 chr1:32538562 TMEM39B 1.21 7.99 0.44 4.16e-14 Granulocyte percentage of myeloid white cells; CESC cis rs7945705 0.935 rs11042103 chr11:8888700 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.48 7.76 0.43 1.81e-13 Hemoglobin concentration; CESC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg18240062 chr17:79603768 NPLOC4 0.51 6.76 0.38 8.81e-11 Eye color traits; CESC cis rs4472734 1.000 rs6540834 chr1:214627419 C/T cg00063699 chr1:214624242 PTPN14 -0.33 -5.05 -0.3 8.33e-7 Height; CESC cis rs7188697 0.882 rs37054 chr16:58558989 C/T cg21335942 chr16:58549945 SETD6 0.47 5.5 0.32 9.04e-8 QT interval; CESC trans rs11098499 0.865 rs2389809 chr4:120377399 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.91 0.52 6.89e-20 Corneal astigmatism; CESC trans rs33794 0.623 rs6808026 chr3:45238131 A/G cg20429833 chr17:6358427 PITPNM3 -0.36 -6.18 -0.35 2.36e-9 Lung function (forced expiratory volume in 1 second); CESC cis rs6424115 0.760 rs2999566 chr1:24051124 A/G cg10978503 chr1:24200527 CNR2 0.27 5.35 0.31 1.89e-7 Immature fraction of reticulocytes; CESC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg24503407 chr1:205819492 PM20D1 0.48 7.28 0.41 3.73e-12 Menarche (age at onset); CESC cis rs9905704 0.918 rs34430710 chr17:56876627 A/T cg12560992 chr17:57184187 TRIM37 0.6 7.0 0.4 2.08e-11 Testicular germ cell tumor; CESC cis rs1950500 0.545 rs1950501 chr14:24806800 C/G cg16194253 chr14:24768981 DHRS1;C14orf21 0.5 6.51 0.37 3.73e-10 Height; CESC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg11644478 chr21:40555479 PSMG1 1.04 17.85 0.74 2.41e-47 Cognitive function; CESC cis rs6665290 0.935 rs6659424 chr1:227197875 A/G cg10327440 chr1:227177885 CDC42BPA -1.22 -33.72 -0.9 7.52e-98 Myeloid white cell count; CESC trans rs7178375 1.000 rs7178375 chr15:31215935 C/T cg04373760 chr16:53404718 NA 0.54 6.97 0.39 2.55e-11 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21496518 chr3:15374154 SH3BP5 0.51 6.56 0.37 2.87e-10 Gut microbiome composition (summer); CESC cis rs1023500 0.505 rs134899 chr22:42683030 T/G cg05082376 chr22:42548792 NA -0.36 -5.33 -0.31 2.08e-7 Schizophrenia; CESC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg05863683 chr7:1912471 MAD1L1 0.37 5.75 0.33 2.47e-8 Bipolar disorder and schizophrenia; CESC cis rs3126085 0.877 rs4456098 chr1:152176034 C/T cg03465714 chr1:152285911 FLG -0.47 -5.69 -0.33 3.29e-8 Atopic dermatitis; CESC cis rs56104184 0.668 rs73063523 chr19:49408943 T/C cg21252483 chr19:49399788 TULP2 -0.52 -5.72 -0.33 2.94e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs1707322 0.717 rs1135812 chr1:46095272 T/C cg06784218 chr1:46089804 CCDC17 0.4 6.97 0.39 2.52e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6032067 1.000 rs62205501 chr20:43864089 G/A cg10761708 chr20:43804764 PI3 0.52 6.26 0.36 1.52e-9 Blood protein levels; CESC cis rs7586879 0.593 rs6733224 chr2:25130907 C/T cg01884057 chr2:25150051 NA -0.37 -7.04 -0.4 1.64e-11 Body mass index; CESC cis rs9584850 0.574 rs61969454 chr13:99170232 T/C cg20750642 chr13:99100586 FARP1 -0.37 -5.32 -0.31 2.17e-7 Neuroticism; CESC cis rs4803468 1.000 rs55986560 chr19:41939835 C/T cg14132834 chr19:41945861 ATP5SL 0.6 7.5 0.42 9.48e-13 Height; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg07611812 chr8:53627203 RB1CC1 0.63 6.17 0.35 2.53e-9 Diastolic blood pressure; CESC cis rs10256972 0.527 rs28671326 chr7:1174973 G/A cg04025307 chr7:1156635 C7orf50 0.6 10.46 0.54 1.15e-21 Longevity;Endometriosis; CESC cis rs7100689 0.646 rs10736346 chr10:82134281 A/C cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs7191700 0.644 rs12149160 chr16:11439303 G/T cg00044050 chr16:11439710 C16orf75 -0.5 -6.3 -0.36 1.24e-9 Multiple sclerosis; CESC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.79e-7 Gut microbiome composition (summer); CESC cis rs6674176 0.597 rs4660262 chr1:44382524 G/A cg13606994 chr1:44402422 ARTN -0.4 -6.29 -0.36 1.33e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7584330 0.554 rs77648388 chr2:238431832 G/C cg14458575 chr2:238380390 NA 0.69 6.48 0.37 4.33e-10 Prostate cancer; CESC cis rs2228479 0.850 rs117880578 chr16:89910230 C/G cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs6088580 0.567 rs6088520 chr20:33132364 A/G cg08999081 chr20:33150536 PIGU -0.64 -10.92 -0.56 3.76e-23 Glomerular filtration rate (creatinine); CESC cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg20503657 chr10:835505 NA 1.1 10.02 0.52 2.94e-20 Eosinophil percentage of granulocytes; CESC cis rs2404602 0.716 rs2404737 chr15:76872217 T/G cg22467129 chr15:76604101 ETFA -0.35 -5.19 -0.3 4.23e-7 Blood metabolite levels; CESC cis rs4835473 0.897 rs55945293 chr4:144625919 A/G cg25736465 chr4:144833511 NA -0.36 -5.44 -0.32 1.23e-7 Immature fraction of reticulocytes; CESC cis rs17095355 1.000 rs9630101 chr10:111738451 T/C cg00817464 chr10:111662876 XPNPEP1 -0.44 -5.2 -0.3 3.98e-7 Biliary atresia; CESC cis rs18122 0.661 rs4671790 chr2:67532139 T/A cg09028215 chr2:67624308 ETAA1 -0.43 -5.23 -0.31 3.44e-7 Waist-to-hip ratio adjusted for body mass index; CESC trans rs877282 0.947 rs7904978 chr10:768078 C/T cg22713356 chr15:30763199 NA 1.17 11.73 0.58 7.23e-26 Uric acid levels; CESC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg19318889 chr4:1322082 MAEA 0.56 6.71 0.38 1.18e-10 Longevity; CESC cis rs1348850 0.554 rs1374438 chr2:178376684 A/G cg22681709 chr2:178499509 PDE11A -0.5 -5.26 -0.31 2.92e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg12379764 chr21:47803548 PCNT 0.47 6.04 0.35 5.07e-9 Testicular germ cell tumor; CESC cis rs7937682 0.924 rs513425 chr11:111504861 C/T cg09085632 chr11:111637200 PPP2R1B -0.99 -16.01 -0.7 8.36e-41 Primary sclerosing cholangitis; CESC cis rs258892 0.947 rs17606 chr5:72184098 C/T cg21869765 chr5:72125136 TNPO1 0.44 5.57 0.32 6.25e-8 Small cell lung carcinoma; CESC cis rs7824557 0.564 rs2043508 chr8:11227406 G/A cg21775007 chr8:11205619 TDH -0.53 -7.77 -0.43 1.76e-13 Retinal vascular caliber; CESC cis rs8114671 0.562 rs6088655 chr20:33527838 A/G cg24642439 chr20:33292090 TP53INP2 0.43 5.13 0.3 5.54e-7 Height; CESC cis rs3820068 0.655 rs59605679 chr1:15863796 T/G cg17385448 chr1:15911702 AGMAT 0.36 5.66 0.33 3.96e-8 Systolic blood pressure; CESC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg16325326 chr1:53192061 ZYG11B 0.75 11.25 0.57 2.93e-24 Monocyte count; CESC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg00784671 chr22:46762841 CELSR1 -0.58 -6.26 -0.36 1.51e-9 LDL cholesterol;Cholesterol, total; CESC cis rs4919687 0.550 rs7907503 chr10:104440050 C/T cg04362960 chr10:104952993 NT5C2 0.44 5.17 0.3 4.55e-7 Colorectal cancer; CESC cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg01579765 chr21:45077557 HSF2BP -0.55 -9.03 -0.48 3.73e-17 Mean corpuscular volume; CESC cis rs7615952 0.673 rs34209763 chr3:125599595 G/A cg05084668 chr3:125655381 ALG1L -0.6 -6.47 -0.37 4.78e-10 Blood pressure (smoking interaction); CESC cis rs15676 0.783 rs3829057 chr9:131567982 A/G cg00228799 chr9:131580591 ENDOG 0.49 6.2 0.36 2.1e-9 Blood metabolite levels; CESC cis rs7772486 0.790 rs2253880 chr6:146200774 T/C cg23711669 chr6:146136114 FBXO30 0.9 13.27 0.63 3.71e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs4699052 0.963 rs4698890 chr4:104181878 T/C cg16532752 chr4:104119610 CENPE -0.45 -6.19 -0.36 2.34e-9 Testicular germ cell tumor; CESC cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.43 5.51 0.32 8.71e-8 Personality dimensions; CESC cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.59 0.47 7.62e-16 Colonoscopy-negative controls vs population controls; CESC cis rs17854409 0.881 rs12625401 chr20:61472939 A/T cg07645718 chr20:61493192 TCFL5 0.8 5.32 0.31 2.26e-7 Obesity-related traits; CESC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.33 0.31 2.11e-7 Tonsillectomy; CESC cis rs965513 1.000 rs925488 chr9:100546391 C/T cg13688889 chr9:100608707 NA -0.59 -8.35 -0.46 3.72e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg13770153 chr20:60521292 NA -0.48 -6.21 -0.36 2e-9 Body mass index; CESC cis rs7267979 1.000 rs4815404 chr20:25301845 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -16.91 -0.72 5.15e-44 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14074042 chr5:159546984 PWWP2A -0.57 -6.65 -0.38 1.65e-10 Gut microbiome composition (summer); CESC cis rs11676348 0.967 rs4674258 chr2:218990586 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.1 -0.35 3.79e-9 Ulcerative colitis; CESC trans rs66573146 1.000 rs55833486 chr4:6978729 C/A cg07817883 chr1:32538562 TMEM39B 1.28 8.51 0.46 1.31e-15 Granulocyte percentage of myeloid white cells; CESC cis rs1185460 0.967 rs1177562 chr11:118949331 C/T cg23280166 chr11:118938394 VPS11 0.54 6.93 0.39 3.16e-11 Coronary artery disease; CESC cis rs2180341 0.782 rs6912006 chr6:127722631 C/T cg27446573 chr6:127587934 RNF146 0.7 9.32 0.5 4.6e-18 Breast cancer; CESC cis rs9611565 0.512 rs5758464 chr22:42171300 A/G cg03806693 chr22:41940476 POLR3H 0.95 8.47 0.46 1.73e-15 Vitiligo; CESC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg22920501 chr2:26401640 FAM59B -0.86 -10.03 -0.52 2.73e-20 Gut microbiome composition (summer); CESC cis rs12122100 0.545 rs1984615 chr1:146506206 G/A cg03526459 chr1:146549940 NA -0.34 -5.3 -0.31 2.4e-7 HIV-1 control; CESC cis rs11864453 0.713 rs12708926 chr16:72126063 T/C cg16558253 chr16:72132732 DHX38 -0.56 -8.7 -0.47 3.62e-16 Fibrinogen levels; CESC cis rs61996546 0.622 rs34886387 chr15:26862107 A/T cg14859324 chr15:26874363 GABRB3 -0.38 -5.19 -0.3 4.11e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs798766 1.000 rs798741 chr4:1712413 A/G cg07041428 chr4:1763019 NA -0.35 -5.11 -0.3 6.05e-7 Bladder cancer;Urinary bladder cancer; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg25065205 chr1:233086286 C1orf57 0.52 6.13 0.35 3.19e-9 Psoriatic arthritis; CESC cis rs7020830 0.894 rs13300951 chr9:37146627 A/G cg14294708 chr9:37120828 ZCCHC7 1.27 25.54 0.84 2.02e-73 Schizophrenia; CESC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg17971929 chr21:40555470 PSMG1 -0.85 -12.27 -0.6 1.01e-27 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13719843 chr19:58897798 RPS5 0.66 7.48 0.42 1.09e-12 Gut microbiome composition (summer); CESC cis rs6540556 0.682 rs667681 chr1:209914449 A/G cg05527609 chr1:210001259 C1orf107 0.63 7.16 0.4 7.78e-12 Red blood cell count; CESC cis rs1499614 1.000 rs2707832 chr7:66136549 C/T cg13147721 chr7:65941812 NA -0.92 -8.41 -0.46 2.5e-15 Gout; CESC cis rs854765 0.583 rs11869536 chr17:17826528 T/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.18 0.45 1.22e-14 Total body bone mineral density; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg00812502 chr22:19109875 DGCR2 -0.43 -6.29 -0.36 1.3e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.59 -0.38 2.36e-10 Depression; CESC cis rs11264213 0.681 rs116324086 chr1:36287771 A/G cg27506609 chr1:36549197 TEKT2 0.61 5.04 0.3 8.54e-7 Schizophrenia; CESC cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7178572 0.743 rs62009090 chr15:77837055 T/G cg22256960 chr15:77711686 NA -0.54 -7.34 -0.41 2.65e-12 Type 2 diabetes; CESC trans rs11039798 0.588 rs7483361 chr11:48593786 G/A cg15704280 chr7:45808275 SEPT13 0.6 6.24 0.36 1.69e-9 Axial length; CESC cis rs1801251 0.964 rs7589201 chr2:233724536 A/G cg08000102 chr2:233561755 GIGYF2 -0.7 -10.05 -0.53 2.42e-20 Coronary artery disease; CESC cis rs7309 0.622 rs4664396 chr2:161901650 C/T cg08807892 chr2:162101083 NA -0.41 -5.29 -0.31 2.62e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CESC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg11764359 chr7:65958608 NA -0.78 -11.17 -0.57 5.37e-24 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03001504 chr20:17663218 RRBP1 0.59 6.88 0.39 4.42e-11 Gut microbiome composition (summer); CESC cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg22875332 chr1:76189707 ACADM -0.64 -7.57 -0.42 6.05e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg03467027 chr4:99064603 C4orf37 0.48 6.15 0.35 2.83e-9 Colonoscopy-negative controls vs population controls; CESC cis rs708547 0.836 rs1277287 chr4:57853147 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.82 10.58 0.55 4.61e-22 Response to bleomycin (chromatid breaks); CESC cis rs3768617 0.510 rs6424884 chr1:183065904 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 14.24 0.66 1.45e-34 Fuchs's corneal dystrophy; CESC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.78 9.64 0.51 4.81e-19 Age-related macular degeneration (geographic atrophy); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg00828305 chr2:178077190 HNRNPA3 0.51 6.07 0.35 4.48e-9 Psoriatic arthritis; CESC trans rs853679 0.556 rs45509595 chr6:27840926 T/C cg06606381 chr12:133084897 FBRSL1 -1.11 -8.93 -0.48 7.41e-17 Depression; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg22087390 chr7:98050531 NA 0.43 6.09 0.35 3.9e-9 Bronchopulmonary dysplasia; CESC cis rs637571 0.522 rs538954 chr11:65756808 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 6.03 0.35 5.46e-9 Eosinophil percentage of white cells; CESC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.62 8.74 0.47 2.77e-16 Bipolar disorder; CESC cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg10253484 chr15:75165896 SCAMP2 0.5 6.72 0.38 1.14e-10 Breast cancer; CESC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg25036284 chr2:26402008 FAM59B 0.86 9.36 0.5 3.44e-18 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18269526 chr11:984455 AP2A2 -0.62 -7.28 -0.41 3.76e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10833576 chr5:72861749 UTP15;ANKRA2 -0.55 -6.22 -0.36 1.89e-9 Gut microbiome composition (summer); CESC cis rs977987 0.806 rs2865531 chr16:75390316 T/A cg03315344 chr16:75512273 CHST6 0.39 5.64 0.33 4.3e-8 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00747290 chr2:42721154 KCNG3 0.58 6.1 0.35 3.64e-9 Gut microbiome composition (summer); CESC cis rs7937682 0.558 rs7113067 chr11:111692182 G/A cg09085632 chr11:111637200 PPP2R1B 0.85 10.37 0.54 2.32e-21 Primary sclerosing cholangitis; CESC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg11644478 chr21:40555479 PSMG1 -0.51 -6.94 -0.39 3.01e-11 Menarche (age at onset); CESC cis rs11166629 1.000 rs11166629 chr8:135636964 C/T cg27224718 chr8:135614730 ZFAT 0.54 6.75 0.38 9.34e-11 Smoking quantity; CESC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg23758822 chr17:41437982 NA 0.99 17.46 0.73 5.87e-46 Menopause (age at onset); CESC cis rs9915657 0.870 rs12941066 chr17:70141226 C/T cg09344028 chr17:70110421 NA 0.34 6.01 0.35 6.13e-9 Thyroid hormone levels; CESC cis rs7923609 1.000 rs7923609 chr10:65133822 A/G cg01631684 chr10:65280961 REEP3 -0.42 -5.18 -0.3 4.32e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs10791097 0.720 rs7119425 chr11:130733185 C/T cg12179176 chr11:130786555 SNX19 0.58 8.87 0.48 1.12e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2228479 1.000 rs117406136 chr16:89974605 C/T cg06558623 chr16:89946397 TCF25 1.16 9.15 0.49 1.54e-17 Skin colour saturation; CESC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg19346786 chr7:2764209 NA -0.51 -7.48 -0.42 1.12e-12 Height; CESC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg21644426 chr2:191273491 MFSD6 0.47 6.48 0.37 4.45e-10 Pulse pressure; CESC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg17971929 chr21:40555470 PSMG1 0.99 13.53 0.64 4.55e-32 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11224423 chr12:56136943 GDF11 0.57 7.05 0.4 1.58e-11 Gut microbiome composition (summer); CESC cis rs4595586 0.545 rs17546137 chr12:39401124 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.57 0.32 6.23e-8 Morning vs. evening chronotype; CESC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg13206674 chr6:150067644 NUP43 0.43 6.04 0.35 5.17e-9 Lung cancer; CESC cis rs847577 0.832 rs1799068 chr7:97707069 G/T cg24562669 chr7:97807699 LMTK2 -0.54 -8.3 -0.45 5.2e-15 Breast cancer; CESC cis rs1670533 1.000 rs6852558 chr4:1059944 C/T cg27284194 chr4:1044797 NA 0.47 6.07 0.35 4.4e-9 Recombination rate (females); CESC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 12.17 0.6 2.39e-27 Alzheimer's disease; CESC cis rs9916302 0.706 rs4795385 chr17:37733148 A/G cg00129232 chr17:37814104 STARD3 0.6 6.11 0.35 3.53e-9 Glomerular filtration rate (creatinine); CESC cis rs4148883 0.675 rs11724783 chr4:100099688 C/A cg13256891 chr4:100009986 ADH5 0.53 6.93 0.39 3.23e-11 Alcohol dependence; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12885832 chr12:111843885 SH2B3 -0.4 -6.01 -0.35 5.99e-9 Gambling; CESC cis rs4919694 0.711 rs113361908 chr10:104978126 T/C cg04362960 chr10:104952993 NT5C2 0.81 6.71 0.38 1.15e-10 Arsenic metabolism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27457339 chr12:69004323 RAP1B 0.5 6.44 0.37 5.48e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6543140 0.964 rs10196334 chr2:103090041 T/C cg04239558 chr2:103089729 SLC9A4 0.48 6.28 0.36 1.36e-9 Blood protein levels; CESC cis rs7918232 0.830 rs7911024 chr10:27433636 A/C cg14442939 chr10:27389572 ANKRD26 0.72 6.92 0.39 3.31e-11 Breast cancer; CESC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg22903657 chr4:1355424 KIAA1530 -0.37 -5.13 -0.3 5.63e-7 Obesity-related traits; CESC cis rs10242455 0.702 rs45461000 chr7:99052710 A/G cg25640893 chr7:99214727 ZNF498 0.72 5.27 0.31 2.78e-7 Blood metabolite levels; CESC cis rs9303401 0.646 rs7217845 chr17:57236900 G/A cg12560992 chr17:57184187 TRIM37 0.43 5.13 0.3 5.62e-7 Cognitive test performance; CESC cis rs1552244 0.554 rs34883592 chr3:10046165 C/T cg00149659 chr3:10157352 C3orf10 0.54 6.55 0.37 2.98e-10 Alzheimer's disease; CESC cis rs889312 0.500 rs865570 chr5:56161975 C/T cg14703610 chr5:56206110 C5orf35 0.48 6.28 0.36 1.38e-9 Breast cancer;Breast cancer (early onset); CESC cis rs854765 0.856 rs2955382 chr17:17947710 C/T cg04398451 chr17:18023971 MYO15A 0.63 8.9 0.48 9.26e-17 Total body bone mineral density; CESC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg13206674 chr6:150067644 NUP43 0.45 6.5 0.37 3.94e-10 Lung cancer; CESC cis rs1256061 0.654 rs1256031 chr14:64746179 C/T cg23250157 chr14:64679961 SYNE2 0.47 6.68 0.38 1.43e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg26400300 chr15:44829086 EIF3J -0.45 -6.08 -0.35 4.17e-9 Recombination measurement; CESC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg21770322 chr7:97807741 LMTK2 0.54 8.17 0.45 1.26e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg13647721 chr17:30228624 UTP6 0.7 6.97 0.39 2.47e-11 Hip circumference adjusted for BMI; CESC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg11764359 chr7:65958608 NA 0.78 11.31 0.57 1.86e-24 Aortic root size; CESC cis rs57244997 0.544 rs77182940 chr6:162443721 T/C cg17173639 chr6:162384350 PARK2 -0.52 -5.49 -0.32 9.45e-8 Mosquito bite size; CESC cis rs4835473 0.897 rs13144504 chr4:144628555 T/C cg25736465 chr4:144833511 NA -0.45 -6.84 -0.39 5.58e-11 Immature fraction of reticulocytes; CESC cis rs7259376 0.902 rs12978477 chr19:22577709 C/G cg02657401 chr19:22469223 NA 0.26 5.15 0.3 5.08e-7 Menopause (age at onset); CESC cis rs854765 0.583 rs6502619 chr17:17779704 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.52 -7.21 -0.41 5.78e-12 Total body bone mineral density; CESC cis rs6541297 1.000 rs2352723 chr1:230291868 C/T cg20703242 chr1:230279135 GALNT2 -0.64 -9.16 -0.49 1.46e-17 Coronary artery disease; CESC cis rs34375054 0.573 rs12831151 chr12:125656263 C/T cg25124228 chr12:125621409 AACS -0.49 -5.43 -0.32 1.28e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs910316 0.967 rs4903285 chr14:75609268 A/T cg11812906 chr14:75593930 NEK9 0.92 16.16 0.7 2.31e-41 Height; CESC cis rs2479106 0.591 rs10760293 chr9:126353327 T/C cg16191174 chr9:126692580 DENND1A 0.37 5.09 0.3 6.82e-7 Polycystic ovary syndrome; CESC cis rs2204008 0.557 rs11520191 chr12:38197057 T/A cg13010199 chr12:38710504 ALG10B 0.51 6.45 0.37 5.18e-10 Bladder cancer; CESC cis rs2075371 0.829 rs35897155 chr7:134002711 G/A cg20476274 chr7:133979776 SLC35B4 0.6 8.4 0.46 2.72e-15 Mean platelet volume; CESC cis rs11785693 0.862 rs73183606 chr8:4986999 C/T cg26367366 chr8:4980734 NA 0.95 8.7 0.47 3.6e-16 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs8078723 1.000 rs4795416 chr17:38158133 C/T cg17467752 chr17:38218738 THRA 0.69 10.55 0.54 5.78e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs2439831 1.000 rs2264239 chr15:43765533 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.85 12.48 0.61 1.94e-28 Lung cancer in ever smokers; CESC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.64 0.43 3.85e-13 Prudent dietary pattern; CESC cis rs7917772 0.636 rs2249845 chr10:104512095 A/G cg04362960 chr10:104952993 NT5C2 0.44 5.14 0.3 5.33e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08555112 chr17:48942811 TOB1 0.5 6.57 0.37 2.63e-10 Gut microbiota (bacterial taxa); CESC cis rs7267979 1.000 rs6037086 chr20:25306338 A/G cg08601574 chr20:25228251 PYGB -0.36 -5.13 -0.3 5.74e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs3733585 0.673 rs7378340 chr4:9955198 C/T cg02734326 chr4:10020555 SLC2A9 -0.38 -5.37 -0.31 1.69e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2075371 1.000 rs2598296 chr7:133992985 C/T cg00033643 chr7:134001901 SLC35B4 0.44 5.57 0.32 6.31e-8 Mean platelet volume; CESC trans rs7618501 0.602 rs2013208 chr3:50129399 C/T cg21659725 chr3:3221576 CRBN -0.5 -6.87 -0.39 4.48e-11 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg23161317 chr6:28129485 ZNF389 0.51 6.43 0.37 5.76e-10 Depression; CESC cis rs2710642 0.751 rs10496099 chr2:62805902 T/C cg17519650 chr2:63277830 OTX1 0.47 5.84 0.34 1.51e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs7551222 0.752 rs4252677 chr1:204495253 G/A cg20240347 chr1:204465584 NA -0.28 -5.66 -0.33 3.86e-8 Schizophrenia; CESC cis rs2688608 0.620 rs12253408 chr10:75495956 G/T cg23231163 chr10:75533350 FUT11 -0.35 -5.28 -0.31 2.68e-7 Inflammatory bowel disease; CESC cis rs8072100 0.967 rs9894905 chr17:45485982 C/T cg25173405 chr17:45401733 C17orf57 -0.41 -5.53 -0.32 7.78e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg11965913 chr1:205819406 PM20D1 0.82 13.95 0.65 1.49e-33 Menarche (age at onset); CESC cis rs7100689 0.784 rs7082102 chr10:82104890 A/C cg09936400 chr10:82049201 MAT1A 0.37 5.53 0.32 7.62e-8 Post bronchodilator FEV1; CESC cis rs2120019 1.000 rs12910644 chr15:75358388 A/G cg17294928 chr15:75287854 SCAMP5 -0.65 -6.96 -0.39 2.66e-11 Blood trace element (Zn levels); CESC cis rs2549003 1.000 rs6894655 chr5:131818649 T/C cg00255919 chr5:131827918 IRF1 0.51 8.62 0.47 6.06e-16 Asthma (sex interaction); CESC cis rs684232 0.666 rs366151 chr17:598311 A/C cg12384639 chr17:618140 VPS53 0.43 5.68 0.33 3.63e-8 Prostate cancer; CESC cis rs7927771 0.524 rs12421563 chr11:47780222 G/A cg20307385 chr11:47447363 PSMC3 -0.58 -8.01 -0.44 3.54e-14 Subjective well-being; CESC trans rs2075371 0.932 rs1862048 chr7:133978167 C/G cg11636714 chr8:42128950 IKBKB 0.48 6.09 0.35 3.91e-9 Mean platelet volume; CESC cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg12463550 chr7:65579703 CRCP 0.54 6.61 0.38 2.07e-10 Aortic root size; CESC cis rs1468333 0.619 rs191968 chr5:137461112 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.49 5.1 0.3 6.6e-7 Resting heart rate; CESC cis rs3026101 0.671 rs55662604 chr17:5297457 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.71 0.33 3.06e-8 Body mass index; CESC cis rs6570726 0.791 rs1509214 chr6:145784606 A/C cg23711669 chr6:146136114 FBXO30 -0.97 -14.31 -0.66 8.35e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs7474896 0.537 rs2749586 chr10:38270214 G/C cg25427524 chr10:38739819 LOC399744 0.49 5.63 0.33 4.63e-8 Obesity (extreme); CESC cis rs897984 0.806 rs9319588 chr16:30930983 C/T cg02466173 chr16:30829666 NA 0.49 8.46 0.46 1.82e-15 Dementia with Lewy bodies; CESC cis rs7923609 0.846 rs7896518 chr10:65104500 A/G cg01631684 chr10:65280961 REEP3 -0.43 -5.33 -0.31 2.1e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs34779708 0.931 rs35317849 chr10:35285721 C/A cg04310649 chr10:35416472 CREM -0.49 -5.91 -0.34 1.03e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs7116495 0.609 rs79889241 chr11:71815585 T/C cg10381502 chr11:71823885 C11orf51 1.08 6.66 0.38 1.56e-10 Severe influenza A (H1N1) infection; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19244826 chr22:19466934 UFD1L;CDC45L 0.46 6.5 0.37 3.93e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg03538708 chr1:25844672 NA -0.4 -6.11 -0.35 3.61e-9 Erythrocyte sedimentation rate; CESC cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg12310025 chr6:25882481 NA -0.64 -9.52 -0.5 1.16e-18 Intelligence (multi-trait analysis); CESC cis rs9894429 0.624 rs9910935 chr17:79613949 T/C cg21984481 chr17:79567631 NPLOC4 -0.49 -7.28 -0.41 3.81e-12 Eye color traits; CESC cis rs9584850 0.540 rs61969407 chr13:99119160 C/T cg20750642 chr13:99100586 FARP1 -0.43 -5.97 -0.34 7.61e-9 Neuroticism; CESC cis rs631288 0.557 rs2354434 chr1:146679428 A/G cg25205988 chr1:146714368 CHD1L 1.04 6.64 0.38 1.78e-10 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs55788414 0.932 rs9929253 chr16:81181641 C/T cg06400318 chr16:81190750 PKD1L2 -0.52 -6.18 -0.35 2.41e-9 Left ventricular obstructive tract defect (maternal effect); CESC cis rs12477438 0.520 rs1044575 chr2:99812070 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.92 15.72 0.69 8.5e-40 Chronic sinus infection; CESC cis rs7208859 0.673 rs2470251 chr17:29095061 T/C cg04154034 chr17:28927549 LRRC37B2 0.56 5.27 0.31 2.89e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg22535103 chr8:58192502 C8orf71 -0.9 -8.95 -0.48 6.29e-17 Developmental language disorder (linguistic errors); CESC cis rs11792861 0.781 rs11793272 chr9:111762102 G/A cg05043794 chr9:111880884 C9orf5 -0.38 -6.14 -0.35 2.93e-9 Menarche (age at onset); CESC cis rs7589342 0.899 rs879900 chr2:106494347 A/G cg16077055 chr2:106428750 NCK2 0.46 6.71 0.38 1.2e-10 Addiction; CESC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg11366901 chr6:160182831 ACAT2 0.88 10.79 0.55 1e-22 Age-related macular degeneration (geographic atrophy); CESC cis rs7178572 0.568 rs12914345 chr15:77670401 A/C cg22256960 chr15:77711686 NA -0.53 -6.76 -0.38 8.88e-11 Type 2 diabetes; CESC cis rs910316 0.737 rs175510 chr14:75524839 G/A cg08847533 chr14:75593920 NEK9 -0.92 -15.88 -0.7 2.27e-40 Height; CESC cis rs12136530 0.593 rs12404783 chr1:19735885 A/C cg01832549 chr1:19774989 CAPZB -0.48 -6.3 -0.36 1.25e-9 Lead levels in blood; CESC trans rs9929218 1.000 rs28660361 chr16:68800838 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.44 -0.46 2.13e-15 Colorectal cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09896403 chr22:24110173 CHCHD10 -0.47 -6.13 -0.35 3.22e-9 Asthma; CESC cis rs6899676 0.539 rs16870736 chr6:10878371 C/G cg17684657 chr6:10886967 SYCP2L 0.47 5.26 0.31 2.99e-7 Menopause (age at onset); CESC cis rs7084402 0.967 rs1649048 chr10:60324282 C/T cg07615347 chr10:60278583 BICC1 0.61 10.0 0.52 3.54e-20 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17298884 chr22:42343226 CENPM 0.63 7.56 0.42 6.81e-13 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg27570636 chr1:214454189 SMYD2 0.47 6.58 0.37 2.53e-10 Systemic lupus erythematosus; CESC trans rs61931739 0.500 rs10844844 chr12:34380350 G/T cg13010199 chr12:38710504 ALG10B 0.47 6.19 0.36 2.31e-9 Morning vs. evening chronotype; CESC cis rs400736 0.524 rs7540528 chr1:8178624 C/T cg25007680 chr1:8021821 PARK7 -0.44 -5.43 -0.32 1.27e-7 Response to antidepressants and depression; CESC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.76 0.38 8.85e-11 Bipolar disorder; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg07949612 chr2:69664562 NFU1 -0.47 -6.25 -0.36 1.61e-9 Recombination measurement; CESC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg23283495 chr1:209979779 IRF6 0.51 7.52 0.42 8.25e-13 Cleft lip with or without cleft palate; CESC trans rs1728785 1.000 rs7118 chr16:68600855 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 7.95 0.44 5.4e-14 Ulcerative colitis; CESC cis rs9611565 0.918 rs9538 chr22:41755857 G/T cg03806693 chr22:41940476 POLR3H -1.03 -11.8 -0.59 4.22e-26 Vitiligo; CESC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC cis rs61935443 1.000 rs61935443 chr12:95249764 G/C cg21533806 chr12:95267307 NA 0.52 6.64 0.38 1.8e-10 Schizophrenia; CESC cis rs10754283 0.967 rs10922679 chr1:90100925 T/C cg21401794 chr1:90099060 LRRC8C 0.7 9.41 0.5 2.54e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg22875332 chr1:76189707 ACADM 0.63 7.33 0.41 2.78e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10751667 0.666 rs4074231 chr11:978219 G/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.48e-7 Alzheimer's disease (late onset); CESC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg24154853 chr7:158122151 PTPRN2 0.43 6.78 0.38 7.65e-11 Calcium levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23912435 chr1:150601613 ENSA -0.47 -6.97 -0.39 2.49e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs55871839 0.684 rs10108037 chr8:59812337 A/C cg07426533 chr8:59803705 TOX -0.47 -7.01 -0.4 1.95e-11 Pneumonia; CESC cis rs12050794 0.636 rs3759902 chr15:72525274 C/G cg16672083 chr15:72433130 SENP8 0.47 7.03 0.4 1.79e-11 Metabolite levels (HVA/MHPG ratio); CESC cis rs1044826 0.642 rs167187 chr3:139237008 C/T cg00490450 chr3:139108681 COPB2 -0.45 -5.52 -0.32 8.17e-8 Obesity-related traits; CESC cis rs2832191 0.791 rs28633762 chr21:30500070 C/T cg24692254 chr21:30365293 RNF160 -0.79 -12.11 -0.6 3.71e-27 Dental caries; CESC cis rs17818399 0.926 rs35350086 chr2:46834036 C/G cg02822958 chr2:46747628 ATP6V1E2 0.48 5.79 0.33 2.02e-8 Height; CESC cis rs7714584 1.000 rs10058821 chr5:150226385 A/G cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg22509189 chr2:225307070 NA 0.4 5.46 0.32 1.11e-7 IgE levels in asthmatics (D.p. specific); CESC cis rs796364 0.760 rs1569178 chr2:201024512 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.78 -6.71 -0.38 1.2e-10 Schizophrenia; CESC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg05863683 chr7:1912471 MAD1L1 0.36 5.21 0.3 3.81e-7 Bipolar disorder and schizophrenia; CESC cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg23711669 chr6:146136114 FBXO30 -1.0 -15.18 -0.68 6.78e-38 Lobe attachment (rater-scored or self-reported); CESC trans rs3942852 0.774 rs2279823 chr11:48146092 T/C cg15704280 chr7:45808275 SEPT13 -0.66 -7.37 -0.41 2.18e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.12 0.3 5.88e-7 Menopause (age at onset); CESC cis rs8077889 0.645 rs1230393 chr17:41842592 A/G cg26893861 chr17:41843967 DUSP3 -1.09 -22.71 -0.81 3.88e-64 Triglycerides; CESC cis rs4727027 0.727 rs3801980 chr7:148878620 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 5.37 0.31 1.69e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs559928 0.606 rs76653616 chr11:63936139 T/G cg18225595 chr11:63971243 STIP1 0.69 6.22 0.36 1.88e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs9611565 0.649 rs202614 chr22:41822150 A/C cg06634786 chr22:41940651 POLR3H 0.71 7.17 0.4 7.6e-12 Vitiligo; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24393316 chr9:100616469 FOXE1 -0.44 -6.41 -0.37 6.45e-10 Gut microbiota (bacterial taxa); CESC cis rs3105593 0.602 rs7165721 chr15:50942452 C/T cg08437265 chr15:50716283 USP8 0.4 5.08 0.3 7.11e-7 QT interval; CESC cis rs6088580 0.634 rs4911420 chr20:32998654 A/G cg08999081 chr20:33150536 PIGU -0.64 -11.72 -0.58 7.75e-26 Glomerular filtration rate (creatinine); CESC cis rs72781680 0.898 rs72788302 chr2:24107246 C/T cg20701182 chr2:24300061 SF3B14 0.78 6.93 0.39 3.11e-11 Lymphocyte counts; CESC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg02269571 chr22:50332266 NA -0.57 -6.99 -0.39 2.29e-11 Schizophrenia; CESC cis rs1023500 0.505 rs134901 chr22:42683520 C/T cg15557168 chr22:42548783 NA -0.43 -6.56 -0.37 2.81e-10 Schizophrenia; CESC cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg02297831 chr4:17616191 MED28 -0.61 -7.89 -0.44 7.9e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs4904167 0.841 rs12878411 chr14:84683539 C/T cg06870609 chr15:89787223 FANCI 0.46 6.06 0.35 4.73e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7918232 0.941 rs1775350 chr10:27441973 C/T cg14240646 chr10:27532245 ACBD5 0.68 6.49 0.37 4.18e-10 Breast cancer; CESC cis rs561341 0.714 rs7218466 chr17:30263314 A/G cg12193833 chr17:30244370 NA -0.49 -5.5 -0.32 9.08e-8 Hip circumference adjusted for BMI; CESC cis rs2952156 1.000 rs2934971 chr17:37854507 G/T cg07936489 chr17:37558343 FBXL20 -0.49 -5.76 -0.33 2.29e-8 Asthma; CESC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg07936489 chr17:37558343 FBXL20 0.81 11.93 0.59 1.5e-26 Glomerular filtration rate (creatinine); CESC cis rs12477438 0.520 rs13009147 chr2:99803998 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.59 0.69 2.54e-39 Chronic sinus infection; CESC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg17376030 chr22:41985996 PMM1 0.67 7.26 0.41 4.21e-12 Vitiligo; CESC cis rs11997175 0.583 rs17780153 chr8:33789161 A/G ch.8.33884649F chr8:33765107 NA 0.45 5.73 0.33 2.78e-8 Body mass index; CESC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg26354017 chr1:205819088 PM20D1 0.42 5.35 0.31 1.9e-7 Parkinson's disease; CESC cis rs2228479 0.718 rs11645376 chr16:89912281 G/C cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs10744422 1.000 rs3817094 chr12:123332032 T/C cg25930673 chr12:123319894 HIP1R -0.73 -5.73 -0.33 2.68e-8 Schizophrenia; CESC cis rs12042107 0.740 rs10922911 chr1:91205831 C/T cg13456504 chr1:91191583 NA -0.33 -5.67 -0.33 3.79e-8 Educational attainment; CESC cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.86 0.34 1.34e-8 Tonsillectomy; CESC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.43 0.57 7.31e-25 Platelet count; CESC cis rs2108622 0.727 rs76984410 chr19:15982700 C/T cg13772218 chr19:15982569 NA 0.29 5.8 0.34 1.85e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg03060546 chr3:49711283 APEH -0.5 -6.25 -0.36 1.6e-9 Menarche (age at onset); CESC cis rs6598955 0.756 rs10902723 chr1:26568542 T/C cg04990556 chr1:26633338 UBXN11 -0.78 -11.35 -0.57 1.35e-24 Obesity-related traits; CESC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg06481639 chr22:41940642 POLR3H -0.61 -6.46 -0.37 4.99e-10 Vitiligo; CESC cis rs367943 0.665 rs4401566 chr5:112963356 A/G cg12552261 chr5:112820674 MCC 0.44 5.61 0.33 4.97e-8 Type 2 diabetes; CESC cis rs1707322 0.721 rs4564187 chr1:46166861 G/C cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.16 0.4 7.91e-12 Depression; CESC cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg00825309 chr19:58991885 ZNF446 -0.55 -7.86 -0.43 9.77e-14 Uric acid clearance; CESC cis rs765787 0.530 rs11636440 chr15:45535982 C/T cg24006582 chr15:45444508 DUOX1 -0.59 -7.29 -0.41 3.52e-12 Uric acid levels; CESC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg15145296 chr3:125709740 NA -0.56 -5.97 -0.34 7.65e-9 Blood pressure (smoking interaction); CESC cis rs11098499 0.820 rs2389885 chr4:120533931 C/T cg09307838 chr4:120376055 NA 0.84 10.64 0.55 2.99e-22 Corneal astigmatism; CESC cis rs2617583 0.967 rs2652509 chr5:1448247 A/G cg07151155 chr5:1473589 LPCAT1 -0.34 -5.13 -0.3 5.61e-7 Breast cancer; CESC cis rs3740713 0.920 rs112973292 chr11:18455888 A/C cg23797887 chr11:18477753 LDHAL6A -0.53 -5.27 -0.31 2.89e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2795502 0.882 rs2744095 chr10:43337949 A/T cg20628663 chr10:43360327 NA -0.63 -7.43 -0.42 1.5e-12 Blood protein levels; CESC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg10691866 chr7:65817282 TPST1 -0.35 -5.62 -0.33 4.9e-8 Aortic root size; CESC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg10691866 chr7:65817282 TPST1 0.32 5.42 0.32 1.35e-7 Aortic root size; CESC cis rs7267979 0.966 rs2261794 chr20:25263062 T/G cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9611565 0.559 rs5758412 chr22:42080803 T/A cg03806693 chr22:41940476 POLR3H 1.09 12.68 0.61 4.09e-29 Vitiligo; CESC cis rs7707921 0.522 rs10065463 chr5:81500280 A/G cg15871215 chr5:81402204 ATG10 -0.46 -6.55 -0.37 2.9e-10 Breast cancer; CESC cis rs17433710 0.516 rs11805556 chr1:162673946 C/T cg21140079 chr1:162667252 DDR2 -0.38 -5.04 -0.3 8.65e-7 Dupuytren's disease; CESC cis rs7520050 0.778 rs3014216 chr1:46035760 A/T cg24296786 chr1:45957014 TESK2 -0.48 -6.18 -0.36 2.37e-9 Red blood cell count;Reticulocyte count; CESC cis rs7940866 0.834 rs10894302 chr11:130861994 C/T cg12179176 chr11:130786555 SNX19 0.69 10.84 0.55 6.65e-23 Schizophrenia; CESC cis rs1215050 0.740 rs6854802 chr4:99065480 A/C cg05340658 chr4:99064831 C4orf37 0.57 7.49 0.42 1.04e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2625529 0.526 rs1035744 chr15:72566615 C/T cg16672083 chr15:72433130 SENP8 0.43 6.49 0.37 4.32e-10 Red blood cell count; CESC cis rs798766 1.000 rs1374469 chr4:1724799 C/T cg05874882 chr4:1763078 NA -0.61 -7.94 -0.44 5.92e-14 Bladder cancer;Urinary bladder cancer; CESC cis rs12155623 0.834 rs16939055 chr8:49824013 T/G cg22283653 chr8:49824208 NA 0.45 6.66 0.38 1.58e-10 Sudden cardiac arrest; CESC cis rs2370759 1.000 rs16933177 chr10:32565705 G/A cg05361325 chr10:32636312 EPC1 -0.6 -5.49 -0.32 9.48e-8 Sexual dysfunction (female); CESC cis rs8077577 0.895 rs62072464 chr17:18108314 T/C cg16794390 chr17:18148240 FLII 0.43 5.92 0.34 1.01e-8 Obesity-related traits; CESC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg24675658 chr1:53192096 ZYG11B -0.7 -10.15 -0.53 1.15e-20 Monocyte count; CESC cis rs67311347 1.000 rs13073003 chr3:40504326 C/T cg01475735 chr3:40494733 NA 0.46 5.83 0.34 1.64e-8 Renal cell carcinoma; CESC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg24829409 chr8:58192753 C8orf71 -0.72 -9.91 -0.52 6.72e-20 Developmental language disorder (linguistic errors); CESC cis rs4718428 0.672 rs12530806 chr7:66390724 A/G cg12165864 chr7:66369176 NA -0.66 -7.74 -0.43 2.12e-13 Corneal structure; CESC trans rs6084875 0.641 rs4815736 chr20:4722761 G/T cg10192164 chr16:30419175 ZNF771 -0.5 -6.16 -0.35 2.7e-9 Systemic lupus erythematosus; CESC cis rs2072732 0.808 rs67908307 chr1:2954297 T/C cg15211996 chr1:2936768 ACTRT2 0.34 6.04 0.35 5.27e-9 Plateletcrit; CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg03395511 chr6:291903 DUSP22 -0.7 -8.87 -0.48 1.1e-16 Menopause (age at onset); CESC trans rs11241261 0.520 rs13185767 chr5:113399323 A/G cg03068319 chr6:17600252 FAM8A1 -0.57 -6.23 -0.36 1.81e-9 Hippocampal sclerosis; CESC cis rs1048238 0.548 rs848217 chr1:16272250 A/G cg21385522 chr1:16154831 NA -0.55 -7.35 -0.41 2.4e-12 Systolic blood pressure; CESC cis rs5769707 0.632 rs1476037 chr22:49991377 G/A cg20744362 chr22:50050164 C22orf34 0.37 5.22 0.31 3.53e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg25019033 chr10:957182 NA -0.57 -5.57 -0.32 6.2e-8 Eosinophil percentage of granulocytes; CESC cis rs8141529 0.509 rs5762864 chr22:29253364 T/C cg15103426 chr22:29168792 CCDC117 0.63 8.51 0.46 1.29e-15 Lymphocyte counts; CESC cis rs4664308 0.875 rs2124969 chr2:160989486 T/C cg03641300 chr2:160917029 PLA2R1 -0.65 -9.49 -0.5 1.44e-18 Idiopathic membranous nephropathy; CESC cis rs909002 0.849 rs4949449 chr1:32088534 T/G cg13919466 chr1:32135498 COL16A1 -0.46 -8.14 -0.45 1.53e-14 Intelligence (multi-trait analysis); CESC cis rs61996546 0.622 rs17560717 chr15:26834211 G/C cg15066197 chr15:26874202 GABRB3 -0.35 -5.07 -0.3 7.55e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg02725872 chr8:58115012 NA -0.38 -5.1 -0.3 6.54e-7 Developmental language disorder (linguistic errors); CESC cis rs4450798 0.793 rs62234798 chr3:13753974 T/C cg05589046 chr3:13742034 LOC285375 0.38 5.65 0.33 4.18e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1348850 0.793 rs6736390 chr2:178480314 T/C cg23306229 chr2:178417860 TTC30B 0.54 6.6 0.38 2.18e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9896933 0.832 rs79103992 chr17:80855483 G/A cg15664640 chr17:80829946 TBCD -0.53 -5.49 -0.32 9.48e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg00149659 chr3:10157352 C3orf10 0.71 8.78 0.47 2.09e-16 Alzheimer's disease; CESC cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg25405998 chr7:65216604 CCT6P1 0.51 5.52 0.32 8.13e-8 Aortic root size; CESC cis rs7216064 0.953 rs4790981 chr17:65921834 A/G cg12091567 chr17:66097778 LOC651250 -0.73 -8.33 -0.46 4.53e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7503807 1.000 rs4890056 chr17:78591211 C/T cg09596252 chr17:78655493 RPTOR -0.44 -6.38 -0.36 7.82e-10 Obesity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13125884 chr15:71408291 CT62 0.44 6.08 0.35 4.28e-9 Gut microbiota (bacterial taxa); CESC cis rs12142240 0.698 rs7525309 chr1:46809025 G/T cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs6460942 0.597 rs4721106 chr7:12535053 T/C cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg11764359 chr7:65958608 NA 0.67 8.85 0.48 1.24e-16 Aortic root size; CESC cis rs8060686 0.641 rs12447640 chr16:68150527 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.07 -0.35 4.37e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs9291683 0.588 rs13133766 chr4:10019732 C/T cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.14e-46 Bone mineral density; CESC cis rs295137 0.836 rs1217456 chr2:201092279 C/T cg23649088 chr2:200775458 C2orf69 0.44 5.77 0.33 2.2e-8 Asthma (bronchodilator response); CESC cis rs34779708 0.966 rs17591857 chr10:35499043 A/G cg04310649 chr10:35416472 CREM 0.52 6.29 0.36 1.29e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs2066819 1.000 rs77032009 chr12:56679971 A/G cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg08109568 chr15:31115862 NA 0.65 9.21 0.49 1.06e-17 Huntington's disease progression; CESC cis rs11997175 0.545 rs4428637 chr8:33666944 T/G ch.8.33884649F chr8:33765107 NA 0.55 6.81 0.39 6.5e-11 Body mass index; CESC cis rs116095464 0.850 rs10055295 chr5:243749 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.63 -0.47 5.66e-16 Breast cancer; CESC cis rs8060686 0.641 rs75796305 chr16:68208791 A/G cg26727032 chr16:67993705 SLC12A4 -0.53 -6.03 -0.35 5.55e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs4332037 0.707 rs73046323 chr7:1882795 G/A cg11693508 chr17:37793320 STARD3 0.61 6.06 0.35 4.61e-9 Bipolar disorder; CESC cis rs7474896 0.583 rs12776092 chr10:38015795 G/C cg25427524 chr10:38739819 LOC399744 -0.49 -5.57 -0.32 6.36e-8 Obesity (extreme); CESC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg22535103 chr8:58192502 C8orf71 -0.47 -5.85 -0.34 1.46e-8 Developmental language disorder (linguistic errors); CESC cis rs2455799 0.574 rs2455801 chr3:15701857 C/T cg16303742 chr3:15540471 COLQ -0.36 -5.59 -0.32 5.55e-8 Mean platelet volume; CESC cis rs858239 0.600 rs6961406 chr7:23134891 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.61 0.42 4.84e-13 Cerebrospinal fluid biomarker levels; CESC cis rs4820539 1.000 rs3827316 chr22:23468538 T/C cg14186256 chr22:23484241 RTDR1 0.82 14.67 0.67 4.55e-36 Bone mineral density; CESC cis rs2439831 0.850 rs10438303 chr15:44016417 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.98 0.44 4.48e-14 Lung cancer in ever smokers; CESC cis rs7116495 0.737 rs7101553 chr11:71753903 C/T cg10381502 chr11:71823885 C11orf51 -1.18 -7.48 -0.42 1.07e-12 Severe influenza A (H1N1) infection; CESC cis rs2952156 0.920 rs2517955 chr17:37843681 C/T cg00129232 chr17:37814104 STARD3 -0.81 -11.91 -0.59 1.71e-26 Asthma; CESC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg22105103 chr4:187893119 NA 0.49 6.86 0.39 4.89e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs10242455 0.702 rs73713521 chr7:99188649 G/A cg25640893 chr7:99214727 ZNF498 0.79 5.37 0.31 1.68e-7 Blood metabolite levels; CESC cis rs6424115 1.000 rs974698 chr1:24132785 C/T cg10978503 chr1:24200527 CNR2 0.28 5.59 0.32 5.65e-8 Immature fraction of reticulocytes; CESC cis rs6582630 0.555 rs10880544 chr12:38473464 G/C cg13010199 chr12:38710504 ALG10B 0.47 6.11 0.35 3.63e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs12893668 0.628 rs57072546 chr14:104063723 T/C cg08213375 chr14:104286397 PPP1R13B 0.32 5.06 0.3 7.76e-7 Reticulocyte count; CESC cis rs2479724 0.840 rs10498752 chr6:41768510 T/C cg08135965 chr6:41755394 TOMM6 -0.43 -5.62 -0.33 4.72e-8 Menarche (age at onset); CESC cis rs6570726 0.935 rs453609 chr6:145812332 T/C cg23711669 chr6:146136114 FBXO30 0.82 12.07 0.6 5.13e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs801193 1.000 rs13239306 chr7:66136017 T/G cg26939375 chr7:64535504 NA -0.58 -7.56 -0.42 6.76e-13 Aortic root size; CESC cis rs7586879 0.638 rs13035244 chr2:25134009 T/C cg01884057 chr2:25150051 NA 0.36 7.03 0.4 1.8e-11 Body mass index; CESC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg10792982 chr14:105748885 BRF1 0.43 5.8 0.34 1.89e-8 Mean platelet volume;Platelet distribution width; CESC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg26354017 chr1:205819088 PM20D1 0.51 7.32 0.41 2.96e-12 Prostate cancer; CESC cis rs2342371 0.848 rs7433483 chr3:196217038 C/T cg15048948 chr3:196158458 UBXN7 -0.43 -5.49 -0.32 9.52e-8 Fat distribution (HIV); CESC cis rs9611565 0.559 rs5751160 chr22:42175695 A/G cg06634786 chr22:41940651 POLR3H 0.67 6.62 0.38 1.93e-10 Vitiligo; CESC cis rs9467773 1.000 rs1321479 chr6:26501897 C/T cg20266910 chr6:26577678 NA -0.31 -5.15 -0.3 5e-7 Intelligence (multi-trait analysis); CESC cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg12386194 chr3:101231763 SENP7 0.45 5.71 0.33 3.05e-8 Colorectal cancer; CESC cis rs2228479 0.867 rs62052185 chr16:89969254 C/T cg06558623 chr16:89946397 TCF25 1.08 8.95 0.48 6.51e-17 Skin colour saturation; CESC cis rs9486719 1.000 rs13202675 chr6:97028427 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.37 -0.46 3.4e-15 Migraine;Coronary artery disease; CESC cis rs798554 0.660 rs1182175 chr7:2875026 C/T cg13628971 chr7:2884303 GNA12 -0.4 -5.34 -0.31 2.03e-7 Height; CESC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg17372223 chr3:52568218 NT5DC2 0.43 6.43 0.37 5.84e-10 Bipolar disorder; CESC cis rs1499972 0.941 rs62263116 chr3:117622719 T/G cg07612923 chr3:117604196 NA 0.86 7.52 0.42 8.43e-13 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10582690 chr10:69644422 SIRT1 0.6 7.1 0.4 1.11e-11 Gut microbiome composition (summer); CESC cis rs244293 0.760 rs8069447 chr17:53008873 A/C cg19360675 chr17:53046073 COX11;STXBP4 -0.48 -6.46 -0.37 5.07e-10 Menarche (age at onset); CESC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg20151795 chr6:28129481 ZNF389 0.44 5.54 0.32 7.16e-8 Depression; CESC cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg23422044 chr7:1970798 MAD1L1 -0.48 -5.11 -0.3 6.07e-7 Bipolar disorder; CESC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg09455208 chr3:40491958 NA 0.51 8.73 0.47 2.97e-16 Renal cell carcinoma; CESC cis rs5417 0.775 rs222852 chr17:7140606 A/G cg13768953 chr17:7114967 DLG4 -0.42 -6.52 -0.37 3.58e-10 Diastolic blood pressure; CESC cis rs7208859 0.673 rs423151 chr17:28952286 A/G cg19761014 chr17:28927070 LRRC37B2 0.8 7.46 0.42 1.24e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11690935 0.851 rs9808259 chr2:172648974 C/T cg13550731 chr2:172543902 DYNC1I2 -0.96 -15.02 -0.68 2.52e-37 Schizophrenia; CESC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg02951883 chr7:2050386 MAD1L1 0.47 6.06 0.35 4.77e-9 Bipolar disorder and schizophrenia; CESC cis rs2447097 0.935 rs2447094 chr17:2294048 A/C cg27406664 chr17:2294951 MNT 0.39 6.49 0.37 4.23e-10 Autism spectrum disorder; CESC cis rs921968 0.613 rs2710251 chr2:219543433 T/C cg02176678 chr2:219576539 TTLL4 -0.38 -6.47 -0.37 4.74e-10 Mean corpuscular hemoglobin concentration; CESC cis rs5771069 0.897 rs137858 chr22:50445601 T/C cg27467552 chr22:50353597 PIM3 -0.51 -7.57 -0.42 6.18e-13 Ulcerative colitis; CESC cis rs12497850 1.000 rs4858798 chr3:48727112 C/T cg06212747 chr3:49208901 KLHDC8B 0.6 8.24 0.45 7.75e-15 Parkinson's disease; CESC cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg00701064 chr4:6280414 WFS1 0.73 13.05 0.63 2.19e-30 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs17021463 0.902 rs11097413 chr4:95249286 C/T cg11021082 chr4:95130006 SMARCAD1 0.56 8.62 0.47 6.2e-16 Testicular germ cell tumor; CESC cis rs10754283 0.935 rs10801756 chr1:90101832 C/T cg21401794 chr1:90099060 LRRC8C 0.7 9.41 0.5 2.54e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs8114671 0.836 rs4911461 chr20:33629993 A/C cg06115741 chr20:33292138 TP53INP2 -0.44 -5.29 -0.31 2.53e-7 Height; CESC cis rs113835537 0.877 rs2275998 chr11:66326581 T/C cg24851651 chr11:66362959 CCS 0.56 5.71 0.33 2.98e-8 Airway imaging phenotypes; CESC cis rs4629180 0.586 rs7583526 chr2:102124665 G/A cg21388029 chr2:102003306 CREG2 0.32 5.14 0.3 5.41e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs854765 0.583 rs7214002 chr17:17852104 G/C cg04398451 chr17:18023971 MYO15A -0.72 -10.46 -0.54 1.13e-21 Total body bone mineral density; CESC cis rs72781680 0.848 rs2339926 chr2:24045734 C/G cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs7264396 0.563 rs2425089 chr20:34304036 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.64 -0.55 3.06e-22 Total cholesterol levels; CESC cis rs72945132 0.882 rs55915603 chr11:70210067 G/T cg14191688 chr11:70257035 CTTN 0.44 5.31 0.31 2.37e-7 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15680989 chr5:1112221 SLC12A7 -0.41 -6.16 -0.35 2.66e-9 Gambling; CESC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg05368731 chr17:41323189 NBR1 0.79 10.96 0.56 2.64e-23 Menopause (age at onset); CESC cis rs2294693 0.530 rs9394761 chr6:41033640 A/C cg14418226 chr6:40996092 UNC5CL 0.45 5.05 0.3 8.09e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs4689388 0.853 rs6817447 chr4:6286847 G/T cg25554036 chr4:6271136 WFS1 0.56 9.29 0.5 5.92e-18 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.73 0.38 1.07e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7178572 0.568 rs3743479 chr15:77406396 A/G cg22256960 chr15:77711686 NA 0.54 6.95 0.39 2.86e-11 Type 2 diabetes; CESC cis rs4865169 0.811 rs6841086 chr4:57903268 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.4 -5.07 -0.3 7.37e-7 Breast cancer; CESC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg04944784 chr2:26401820 FAM59B 0.76 8.13 0.45 1.61e-14 Gut microbiome composition (summer); CESC cis rs7917772 0.636 rs10786708 chr10:104526245 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.44 5.19 0.3 4.17e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs8018808 0.869 rs4369582 chr14:77906389 C/T cg20045696 chr14:77926864 AHSA1 0.42 5.83 0.34 1.61e-8 Myeloid white cell count; CESC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.62 8.43 0.46 2.31e-15 Menarche (age at onset); CESC cis rs763121 0.853 rs6001175 chr22:39018334 T/C cg06544989 chr22:39130855 UNC84B 0.51 9.29 0.5 5.78e-18 Menopause (age at onset); CESC trans rs61931739 0.853 rs7133716 chr12:34041847 G/C cg26384229 chr12:38710491 ALG10B -0.46 -6.16 -0.35 2.75e-9 Morning vs. evening chronotype; CESC cis rs1023500 0.573 rs6002592 chr22:42476754 A/C cg04733989 chr22:42467013 NAGA -0.83 -12.7 -0.62 3.37e-29 Schizophrenia; CESC cis rs735396 0.770 rs1169314 chr12:121443116 A/G cg25281562 chr12:121454272 C12orf43 0.51 6.45 0.37 5.17e-10 N-glycan levels; CESC cis rs7666738 0.512 rs1648536 chr4:99019881 G/T cg05340658 chr4:99064831 C4orf37 -0.59 -7.87 -0.44 8.86e-14 Colonoscopy-negative controls vs population controls; CESC cis rs9443189 0.806 rs9359139 chr6:76487269 C/G cg01950844 chr6:76311363 SENP6 0.65 6.71 0.38 1.19e-10 Prostate cancer; CESC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.0 0.39 2.13e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00862481 chr16:29998852 TAOK2 -0.63 -7.45 -0.42 1.34e-12 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg11764359 chr7:65958608 NA -0.79 -11.58 -0.58 2.22e-25 Aortic root size; CESC cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg18099408 chr3:52552593 STAB1 0.3 5.09 0.3 6.93e-7 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23931027 chr7:2142553 MAD1L1 -0.56 -6.77 -0.38 8.27e-11 Gut microbiome composition (summer); CESC cis rs11683229 0.777 rs12474184 chr2:63253594 A/T cg17519650 chr2:63277830 OTX1 -0.76 -5.99 -0.35 6.65e-9 Protein quantitative trait loci; CESC trans rs2727020 0.619 rs1164665 chr11:49295630 T/C cg15704280 chr7:45808275 SEPT13 0.78 10.35 0.54 2.56e-21 Coronary artery disease; CESC cis rs9796 0.636 rs1983400 chr15:41373029 T/C cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.28 -0.36 1.39e-9 Menopause (age at onset); CESC cis rs11864453 0.612 rs12924413 chr16:72129745 T/C cg01557791 chr16:72042693 DHODH -0.43 -5.66 -0.33 3.85e-8 Fibrinogen levels; CESC cis rs4450131 0.522 rs11245328 chr10:126358413 G/A cg20435097 chr10:126320824 FAM53B 0.29 5.18 0.3 4.31e-7 White blood cell count (basophil); CESC cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg06766960 chr11:133703094 NA -0.38 -5.38 -0.31 1.65e-7 Childhood ear infection; CESC cis rs2456568 0.741 rs9633811 chr11:93628327 A/G cg26875233 chr11:93583750 C11orf90 0.3 5.15 0.3 5.2e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC trans rs2727020 0.658 rs4980431 chr11:49350071 G/T cg03929089 chr4:120376271 NA -0.78 -11.96 -0.59 1.21e-26 Coronary artery disease; CESC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg11764359 chr7:65958608 NA -0.82 -12.01 -0.59 8.19e-27 Aortic root size; CESC cis rs34779708 0.966 rs4934732 chr10:35431684 T/C cg03585969 chr10:35415529 CREM 0.74 9.84 0.52 1.13e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg01097406 chr16:89675127 NA 0.39 5.51 0.32 8.35e-8 Vitiligo; CESC cis rs2952156 0.959 rs2934952 chr17:37832366 G/A cg20243544 chr17:37824526 PNMT 0.6 7.33 0.41 2.71e-12 Asthma; CESC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg00684032 chr4:1343700 KIAA1530 0.4 5.56 0.32 6.51e-8 Obesity-related traits; CESC cis rs2279817 1.000 rs10888048 chr1:18019742 C/T cg21791023 chr1:18019539 ARHGEF10L 0.58 8.5 0.46 1.36e-15 Neuroticism; CESC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg04546413 chr19:29218101 NA 0.56 8.14 0.45 1.58e-14 Methadone dose in opioid dependence; CESC cis rs12912251 0.947 rs12898460 chr15:38986813 C/T cg01338139 chr15:38987640 C15orf53 -0.5 -5.71 -0.33 3.05e-8 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg12927641 chr6:109611667 NA -0.43 -6.65 -0.38 1.67e-10 Reticulocyte fraction of red cells; CESC cis rs116095464 0.558 rs10077076 chr5:231940 C/T cg10591111 chr5:226296 SDHA -0.52 -6.37 -0.36 8.3e-10 Breast cancer; CESC cis rs8072100 0.967 rs4793842 chr17:45671506 G/A cg08085267 chr17:45401833 C17orf57 0.4 5.15 0.3 5.18e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg24768116 chr2:27665128 KRTCAP3 -0.33 -5.98 -0.34 7.16e-9 Total body bone mineral density; CESC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.24 -0.31 3.23e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6460942 1.000 rs62448566 chr7:12403662 G/A cg02935154 chr7:12443704 VWDE -0.56 -6.1 -0.35 3.8e-9 Coronary artery disease; CESC cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg22875332 chr1:76189707 ACADM -0.62 -6.57 -0.37 2.73e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs5753618 0.561 rs2413049 chr22:31686144 A/G cg13145458 chr22:31556086 RNF185 0.49 5.48 0.32 9.7e-8 Colorectal cancer; CESC cis rs2932538 0.922 rs12402929 chr1:113072293 G/C cg22162597 chr1:113214053 CAPZA1 0.56 6.52 0.37 3.58e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs1153858 1.000 rs1145074 chr15:45703824 T/A cg21132104 chr15:45694354 SPATA5L1 0.78 10.3 0.53 3.93e-21 Homoarginine levels; CESC cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg03467027 chr4:99064603 C4orf37 0.48 5.95 0.34 8.45e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg08888203 chr3:10149979 C3orf24 -0.5 -6.52 -0.37 3.48e-10 Alzheimer's disease; CESC cis rs7188697 0.646 rs7184114 chr16:58585369 C/A cg21335942 chr16:58549945 SETD6 -0.49 -6.04 -0.35 5.09e-9 QT interval; CESC cis rs10197940 0.638 rs2288193 chr2:152348842 T/A cg19508488 chr2:152266495 RIF1 0.53 5.62 0.33 4.74e-8 Lung cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14462015 chr4:79860507 PAQR3 -0.43 -6.32 -0.36 1.1e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.58 0.37 2.44e-10 Electroencephalogram traits; CESC cis rs701145 0.556 rs355751 chr3:153971602 T/C cg16511985 chr3:153974050 SGEF 0.41 5.5 0.32 8.81e-8 Coronary artery disease; CESC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg11644478 chr21:40555479 PSMG1 -0.53 -7.15 -0.4 8.46e-12 Menarche (age at onset); CESC cis rs7178572 1.000 rs11633054 chr15:77747276 A/G cg22256960 chr15:77711686 NA -0.57 -7.48 -0.42 1.08e-12 Type 2 diabetes; CESC cis rs425277 1.000 rs421992 chr1:2077260 C/T cg04315214 chr1:2043799 PRKCZ -0.38 -5.34 -0.31 2.03e-7 Height; CESC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg11890956 chr21:40555474 PSMG1 -0.65 -9.09 -0.49 2.43e-17 Menarche (age at onset); CESC cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg25072359 chr17:41440525 NA 0.45 5.96 0.34 7.83e-9 Menopause (age at onset); CESC cis rs644799 0.965 rs10831426 chr11:95505888 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.44 0.5 1.99e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1005224 0.926 rs12892551 chr14:76159902 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.42 -5.86 -0.34 1.36e-8 Large artery stroke; CESC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.93 9.11 0.49 2.01e-17 Gut microbiome composition (summer); CESC cis rs728616 0.867 rs1923534 chr10:81710485 A/G cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg00106254 chr7:1943704 MAD1L1 0.48 6.16 0.35 2.69e-9 Bipolar disorder and schizophrenia; CESC cis rs10465746 0.967 rs12748268 chr1:84374438 T/C cg10977910 chr1:84465055 TTLL7 0.47 6.34 0.36 9.84e-10 Obesity-related traits; CESC cis rs1499972 0.618 rs73168386 chr3:117644339 T/C cg07612923 chr3:117604196 NA 0.71 6.53 0.37 3.35e-10 Schizophrenia; CESC cis rs3741151 0.773 rs73548688 chr11:73279544 C/T cg17517138 chr11:73019481 ARHGEF17 1.02 7.54 0.42 7.35e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7216064 1.000 rs9912084 chr17:65868035 A/C cg07042672 chr17:66097459 LOC651250 -0.57 -6.57 -0.37 2.69e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1144333 1.000 rs5745354 chr1:76275178 G/A cg22875332 chr1:76189707 ACADM -0.58 -6.02 -0.35 5.91e-9 Attention function in attention deficit hyperactive disorder; CESC cis rs56804039 1.000 rs34154295 chr8:8383477 C/T cg15556689 chr8:8085844 FLJ10661 -0.48 -5.21 -0.3 3.76e-7 Cervical cancer; CESC cis rs9399135 0.967 rs12527683 chr6:135324534 C/T cg24558204 chr6:135376177 HBS1L 0.52 7.1 0.4 1.15e-11 Red blood cell count; CESC cis rs35110281 0.667 rs914197 chr21:45117439 A/G cg21573476 chr21:45109991 RRP1B -0.55 -7.91 -0.44 6.87e-14 Mean corpuscular volume; CESC cis rs4588572 0.644 rs6882191 chr5:77743098 G/A cg11547950 chr5:77652471 NA -0.4 -5.46 -0.32 1.12e-7 Triglycerides; CESC cis rs7511006 1.000 rs7511006 chr22:50676259 T/C cg16473166 chr22:50639996 SELO 0.5 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg25554036 chr4:6271136 WFS1 0.55 8.68 0.47 4.02e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.04 -0.3 8.71e-7 Total body bone mineral density; CESC cis rs7215564 0.908 rs4969246 chr17:78740579 G/A cg11222173 chr17:78748019 RPTOR 0.55 5.04 0.3 8.62e-7 Myopia (pathological); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20047825 chr8:145981074 ZNF251 0.53 6.04 0.35 5.1e-9 Gut microbiome composition (summer); CESC cis rs12188164 0.543 rs2434695 chr5:464177 C/G cg16584290 chr5:462447 EXOC3 0.46 7.05 0.4 1.51e-11 Cystic fibrosis severity; CESC cis rs2637266 0.905 rs60809084 chr10:78374431 A/C cg18941641 chr10:78392320 NA 0.4 7.48 0.42 1.06e-12 Pulmonary function; CESC cis rs2742234 0.590 rs2435376 chr10:43684963 A/G cg15436174 chr10:43711423 RASGEF1A -0.5 -5.84 -0.34 1.5e-8 Hirschsprung disease; CESC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg24675658 chr1:53192096 ZYG11B 0.53 6.73 0.38 1.04e-10 Monocyte count; CESC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9486719 0.948 rs12203657 chr6:96883285 G/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs78889164 0.956 rs79602905 chr19:33875394 G/T cg02272751 chr19:33882848 PEPD -0.54 -7.37 -0.41 2.13e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs208520 0.909 rs55813840 chr6:67012508 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.81 7.68 0.43 3.1400000000000003e-13 Exhaled nitric oxide output; CESC cis rs2243480 1.000 rs58669269 chr7:65951953 T/C cg18252515 chr7:66147081 NA -1.41 -14.24 -0.66 1.46e-34 Diabetic kidney disease; CESC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg11494091 chr17:61959527 GH2 0.73 12.69 0.61 3.72e-29 Prudent dietary pattern; CESC cis rs17826219 0.706 rs73271850 chr17:29142140 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Body mass index; CESC cis rs17376456 0.877 rs9314092 chr5:93326362 A/G cg21475434 chr5:93447410 FAM172A 0.76 6.79 0.38 7.5e-11 Diabetic retinopathy; CESC cis rs6963495 0.818 rs73192115 chr7:105169605 T/A cg19920283 chr7:105172520 RINT1 0.69 6.54 0.37 3.15e-10 Bipolar disorder (body mass index interaction); CESC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.57 0.58 2.41e-25 Platelet count; CESC cis rs7173419 0.607 rs11637338 chr15:28217259 C/T cg20906524 chr15:28200668 OCA2 -0.38 -5.25 -0.31 3.07e-7 Eye color; CESC cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg23711669 chr6:146136114 FBXO30 0.83 12.05 0.6 5.75e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs2487048 0.725 rs2422493 chr9:107690995 G/A cg14470647 chr9:107690075 ABCA1 -0.58 -7.29 -0.41 3.61e-12 Intraocular pressure; CESC cis rs11997175 0.646 rs2006792 chr8:33694423 G/A ch.8.33884649F chr8:33765107 NA 0.56 7.34 0.41 2.56e-12 Body mass index; CESC cis rs15676 0.947 rs3115874 chr9:131579338 G/C cg00228799 chr9:131580591 ENDOG 0.43 5.4 0.31 1.48e-7 Blood metabolite levels; CESC cis rs9902453 0.874 rs11653805 chr17:28378276 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -8.69 -0.47 3.92e-16 Coffee consumption (cups per day); CESC cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.832 rs7105851 chr11:47383275 T/C cg18512352 chr11:47633146 NA 0.51 7.28 0.41 3.89e-12 Subjective well-being; CESC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.75 0.33 2.41e-8 Bipolar disorder; CESC cis rs9549367 0.789 rs9577218 chr13:113894911 A/G cg18105134 chr13:113819100 PROZ -0.7 -8.81 -0.48 1.68e-16 Platelet distribution width; CESC cis rs698813 0.851 rs698807 chr2:44701659 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.54 0.32 7.43e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs11122272 0.735 rs2790876 chr1:231536033 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.08 0.35 4.22e-9 Hemoglobin concentration; CESC cis rs4971059 0.617 rs10908458 chr1:155126948 T/C cg22049894 chr1:155113146 DPM3 0.47 6.07 0.35 4.4e-9 Breast cancer; CESC cis rs713587 0.563 rs2033655 chr2:25101092 C/T cg01884057 chr2:25150051 NA 0.31 5.71 0.33 3.05e-8 Body mass index in non-asthmatics; CESC cis rs61931739 0.500 rs7306053 chr12:34510848 T/G cg06521331 chr12:34319734 NA -0.37 -5.09 -0.3 6.85e-7 Morning vs. evening chronotype; CESC cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg25019033 chr10:957182 NA -0.55 -5.42 -0.32 1.34e-7 Eosinophil percentage of granulocytes; CESC cis rs7089973 0.604 rs10885620 chr10:116630048 A/T cg25233709 chr10:116636983 FAM160B1 0.39 6.56 0.37 2.89e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6690583 0.623 rs12033900 chr1:85478559 T/C cg22153463 chr1:85462885 MCOLN2 0.79 7.52 0.42 8.55e-13 Serum sulfate level; CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.46 6.09 0.35 3.89e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16920189 chr15:100105709 MEF2A 0.52 6.12 0.35 3.35e-9 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg10691866 chr7:65817282 TPST1 0.34 5.76 0.33 2.28e-8 Aortic root size; CESC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.53 5.24 0.31 3.26e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7503807 0.905 rs9909449 chr17:78614393 A/G cg09596252 chr17:78655493 RPTOR 0.52 7.73 0.43 2.3e-13 Obesity; CESC cis rs7539409 0.915 rs4001467 chr1:84275858 A/T cg10977910 chr1:84465055 TTLL7 -0.56 -5.48 -0.32 9.69e-8 Alzheimer's disease; CESC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg25767906 chr1:53392781 SCP2 -0.48 -6.23 -0.36 1.78e-9 Monocyte count; CESC trans rs1994135 0.617 rs2200155 chr12:33734935 G/A cg26384229 chr12:38710491 ALG10B 0.45 6.5 0.37 4.08e-10 Resting heart rate; CESC cis rs17021463 0.673 rs12646467 chr4:95288819 G/A cg11021082 chr4:95130006 SMARCAD1 0.5 6.92 0.39 3.3e-11 Testicular germ cell tumor; CESC cis rs4764124 0.646 rs10846062 chr12:14965781 T/C cg19759883 chr12:14956454 WBP11;C12orf60 0.57 8.45 0.46 1.94e-15 Pubertal anthropometrics; CESC cis rs1577917 1.000 rs1337844 chr6:86677273 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -5.61 -0.33 5.02e-8 Response to antipsychotic treatment; CESC cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.61 0.33 5.08e-8 Colonoscopy-negative controls vs population controls; CESC cis rs3806843 0.966 rs1030163 chr5:140185132 G/A cg26395211 chr5:140044315 WDR55 -0.42 -5.33 -0.31 2.07e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7589728 1.000 rs7425670 chr2:88522028 C/T cg04511125 chr2:88470314 THNSL2 0.51 5.04 0.3 8.55e-7 Plasma clusterin levels; CESC cis rs1953600 0.715 rs1079242 chr10:81917708 C/T cg00277334 chr10:82204260 NA 0.4 5.44 0.32 1.22e-7 Sarcoidosis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03158666 chr17:7199744 NA -0.46 -6.02 -0.35 5.79e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19098314 chr17:28804347 GOSR1 -0.58 -7.1 -0.4 1.18e-11 Gut microbiome composition (summer); CESC cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.11 -0.3 6.19e-7 Developmental language disorder (linguistic errors); CESC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg11663144 chr21:46675770 NA -0.63 -10.04 -0.53 2.57e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1348850 0.958 rs1545364 chr2:178462882 G/T cg23306229 chr2:178417860 TTC30B 0.56 7.42 0.41 1.61e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.55 7.35 0.41 2.52e-12 Lymphocyte counts; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14574726 chr11:809735 RPLP2 0.46 6.76 0.38 8.74e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3105593 1.000 rs17645826 chr15:50950141 T/C cg08437265 chr15:50716283 USP8 0.42 5.36 0.31 1.85e-7 QT interval; CESC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.57 7.68 0.43 3.13e-13 Lymphocyte counts; CESC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg19468946 chr17:37922297 IKZF3 0.39 5.09 0.3 6.92e-7 Glomerular filtration rate (creatinine); CESC cis rs7188697 0.809 rs4784956 chr16:58596291 A/C cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg18099408 chr3:52552593 STAB1 -0.32 -5.42 -0.32 1.37e-7 Electroencephalogram traits; CESC cis rs1801251 0.835 rs1446310 chr2:233683245 G/C cg08000102 chr2:233561755 GIGYF2 -0.72 -11.29 -0.57 2.1e-24 Coronary artery disease; CESC cis rs666930 0.519 rs532303 chr1:120265444 A/G cg19096424 chr1:120255104 PHGDH 0.68 7.88 0.44 8.32e-14 Breast cancer; CESC cis rs853679 1.000 rs6901575 chr6:28250984 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.68 6.91 0.39 3.68e-11 Depression; CESC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg05313129 chr8:58192883 C8orf71 0.51 5.35 0.31 1.91e-7 Developmental language disorder (linguistic errors); CESC cis rs12893668 0.667 rs8017628 chr14:104047428 C/T cg24130564 chr14:104152367 KLC1 -0.49 -6.23 -0.36 1.78e-9 Reticulocyte count; CESC cis rs2180341 0.814 rs6905553 chr6:127727407 A/G cg24812749 chr6:127587940 RNF146 0.84 12.05 0.59 5.93e-27 Breast cancer; CESC cis rs765787 0.530 rs4774550 chr15:45542312 C/T cg24006582 chr15:45444508 DUOX1 -0.57 -6.97 -0.39 2.58e-11 Uric acid levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05518842 chr16:1823291 MRPS34;EME2 0.51 6.77 0.38 8.29e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg14703610 chr5:56206110 C5orf35 -0.46 -5.57 -0.32 6.17e-8 Coronary artery disease; CESC cis rs10089 0.953 rs13358455 chr5:127365786 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 9.55 0.51 8.83e-19 Ileal carcinoids; CESC cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg18904891 chr8:8559673 CLDN23 -0.41 -5.03 -0.3 8.87e-7 Mood instability; CESC cis rs16854884 0.586 rs7611326 chr3:143736374 C/T cg06585982 chr3:143692056 C3orf58 0.5 6.75 0.38 9.19e-11 Economic and political preferences (feminism/equality); CESC cis rs911555 0.692 rs7146215 chr14:103915908 A/G cg24130564 chr14:104152367 KLC1 0.5 6.5 0.37 4.05e-10 Intelligence (multi-trait analysis); CESC cis rs11190604 1.000 rs1800662 chr10:102289078 C/A cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs6570726 0.935 rs429306 chr6:145827016 T/C cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg00630080 chr16:67264248 FHOD1 0.45 6.39 0.37 7.25e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9649465 0.561 rs631445 chr7:123413707 C/T cg03229431 chr7:123269106 ASB15 -0.41 -5.53 -0.32 7.63e-8 Migraine; CESC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 11.17 0.57 5.29e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7089973 0.604 rs3758603 chr10:116605368 T/C cg23260525 chr10:116636907 FAM160B1 0.4 7.2 0.4 6.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg05283184 chr6:79620031 NA -0.43 -6.56 -0.37 2.85e-10 Intelligence (multi-trait analysis); CESC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg16743903 chr16:89593216 SPG7 -0.48 -6.39 -0.37 7.61e-10 Multiple myeloma (IgH translocation); CESC cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6998277 1.000 rs62523306 chr8:103640752 C/A cg10187029 chr8:103597600 NA 0.61 6.88 0.39 4.37e-11 Migraine; CESC cis rs6691722 0.503 rs3765428 chr1:24706113 G/A cg02336364 chr1:24764700 NIPAL3 0.33 6.8 0.39 6.86e-11 Response to interferon beta in multiple sclerosis; CESC cis rs4523957 0.928 rs216198 chr17:2201735 C/T cg16513277 chr17:2031491 SMG6 0.57 7.67 0.43 3.23e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs12479064 0.724 rs3792143 chr2:100057020 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -7.06 -0.4 1.45e-11 Chronic sinus infection; CESC cis rs9926296 0.632 rs72807526 chr16:89775946 A/G cg03388025 chr16:89894329 SPIRE2 -0.31 -5.32 -0.31 2.17e-7 Vitiligo; CESC cis rs7833986 0.534 rs17759244 chr8:57033768 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.57 7.28 0.41 3.83e-12 Height; CESC cis rs1055129 0.655 rs7223416 chr17:73836162 C/G cg08125733 chr17:73851984 WBP2 0.55 7.58 0.42 6e-13 White matter hyperintensity burden; CESC cis rs1023500 0.507 rs6002600 chr22:42488906 G/A cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Schizophrenia; CESC cis rs2228479 0.867 rs12919804 chr16:89945369 G/A cg04013166 chr16:89971882 TCF25 0.77 7.14 0.4 8.86e-12 Skin colour saturation; CESC cis rs1008375 0.902 rs12503164 chr4:17656107 C/T cg15017067 chr4:17643749 FAM184B 0.36 5.17 0.3 4.73e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg22823121 chr1:150693482 HORMAD1 0.47 7.05 0.4 1.54e-11 Tonsillectomy; CESC cis rs12142240 0.698 rs6679898 chr1:46820589 A/C cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.15 0.4 8.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7264396 0.561 rs6060753 chr20:34598430 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -6.82 -0.39 6.33e-11 Total cholesterol levels; CESC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg18252515 chr7:66147081 NA -0.47 -6.41 -0.37 6.57e-10 Aortic root size; CESC cis rs12956009 0.583 rs16951972 chr18:44898600 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.49 0.37 4.11e-10 Educational attainment (years of education); CESC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg07936489 chr17:37558343 FBXL20 -0.8 -11.95 -0.59 1.31e-26 Glomerular filtration rate (creatinine); CESC cis rs4704187 0.687 rs10462354 chr5:74453027 T/G cg03227963 chr5:74354835 NA 0.3 5.5 0.32 8.75e-8 Response to amphetamines; CESC cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg14416269 chr4:6271139 WFS1 0.47 7.87 0.44 8.86e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg11764359 chr7:65958608 NA 0.66 8.47 0.46 1.66e-15 Aortic root size; CESC cis rs2797160 1.000 rs6904992 chr6:126016003 G/A cg05901451 chr6:126070800 HEY2 0.46 6.55 0.37 2.89e-10 Endometrial cancer; CESC cis rs116095464 0.558 rs62347683 chr5:230331 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.65 -0.47 5.2e-16 Breast cancer; CESC cis rs7264396 0.563 rs2425103 chr20:34312329 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.86 0.39 4.8e-11 Total cholesterol levels; CESC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg22920501 chr2:26401640 FAM59B -0.85 -10.05 -0.53 2.42e-20 Gut microbiome composition (summer); CESC cis rs6088580 0.602 rs6059834 chr20:33019299 A/G cg08999081 chr20:33150536 PIGU 0.65 11.36 0.57 1.22e-24 Glomerular filtration rate (creatinine); CESC cis rs317689 0.690 rs547827 chr12:69669703 G/A cg14784868 chr12:69753453 YEATS4 0.47 5.16 0.3 4.75e-7 Response to diuretic therapy; CESC cis rs6840258 1.000 rs72667752 chr4:87939531 G/A cg08197287 chr4:87952173 AFF1 -0.41 -5.57 -0.32 6.14e-8 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs748404 0.660 rs548704 chr15:43791706 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.21 0.45 9.59e-15 Lung cancer; CESC cis rs561341 0.883 rs2074102 chr17:30228884 G/A cg00745463 chr17:30367425 LRRC37B -0.64 -6.28 -0.36 1.38e-9 Hip circumference adjusted for BMI; CESC cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.46 -6.05 -0.35 4.83e-9 Tonsillectomy; CESC cis rs6748734 1.000 rs4293565 chr2:241834770 A/G cg07537917 chr2:241836409 C2orf54 -0.26 -5.72 -0.33 2.95e-8 Urinary metabolites; CESC cis rs4076764 0.846 rs7525724 chr1:163426372 G/A cg24596788 chr1:163392923 NA -0.41 -5.81 -0.34 1.76e-8 Motion sickness; CESC cis rs4253772 0.591 rs73886791 chr22:46687212 A/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.55 5.66 0.33 3.89e-8 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg03188948 chr7:1209495 NA 0.44 5.6 0.33 5.48e-8 Longevity;Endometriosis; CESC cis rs2243480 1.000 rs781157 chr7:65478311 G/A cg18252515 chr7:66147081 NA -1.12 -10.8 -0.55 9.01e-23 Diabetic kidney disease; CESC cis rs6582630 0.555 rs8189479 chr12:38308240 C/T cg26384229 chr12:38710491 ALG10B -0.44 -5.7 -0.33 3.17e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs4648845 0.777 rs2477689 chr1:2395538 G/C cg11214544 chr1:2391121 NA -0.38 -5.99 -0.35 6.83e-9 Schizophrenia; CESC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg22823121 chr1:150693482 HORMAD1 -0.41 -6.39 -0.37 7.49e-10 Tonsillectomy; CESC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.55 0.46 1.01e-15 Menopause (age at onset); CESC cis rs11252926 0.931 rs4881399 chr10:567325 A/G cg18196295 chr10:418757 DIP2C 0.42 5.05 0.3 8.08e-7 Psychosis in Alzheimer's disease; CESC cis rs12541635 0.966 rs62525734 chr8:106984056 T/C cg10147462 chr8:107024639 NA 0.41 5.62 0.33 4.88e-8 Age of smoking initiation; CESC cis rs9486719 1.000 rs12190507 chr6:96898265 T/G cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.21e-15 Migraine;Coronary artery disease; CESC trans rs4906172 0.773 rs11844113 chr14:102513596 A/G cg17920195 chr4:129149383 NA 0.32 6.1 0.35 3.66e-9 Menopause (age at onset); CESC cis rs7772486 0.692 rs2265915 chr6:146194332 A/T cg23711669 chr6:146136114 FBXO30 1.02 15.84 0.7 3.24e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs7116495 0.619 rs7116188 chr11:71841753 A/G cg10381502 chr11:71823885 C11orf51 0.7 5.7 0.33 3.22e-8 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22277887 chr6:75994754 TMEM30A 0.52 6.22 0.36 1.91e-9 Gut microbiome composition (summer); CESC cis rs6141600 0.760 rs6060794 chr20:34682864 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -5.52 -0.32 8.06e-8 Height;Hip circumference; CESC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg10541313 chr22:46663664 TTC38 0.74 5.91 0.34 1.05e-8 LDL cholesterol;Cholesterol, total; CESC cis rs2637266 0.935 rs7393727 chr10:78365977 T/A cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC cis rs4076764 1.000 rs4469696 chr1:163424565 C/T cg24596788 chr1:163392923 NA -0.47 -6.89 -0.39 4.15e-11 Motion sickness; CESC cis rs4481887 0.800 rs4278391 chr1:248450495 C/T cg00666640 chr1:248458726 OR2T12 0.38 6.23 0.36 1.8e-9 Common traits (Other); CESC cis rs8077889 0.703 rs72836567 chr17:41945776 G/A cg26893861 chr17:41843967 DUSP3 0.74 6.82 0.39 6.31e-11 Triglycerides; CESC cis rs631288 0.793 rs6681716 chr1:146707824 A/C cg25205988 chr1:146714368 CHD1L 0.77 7.38 0.41 1.99e-12 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs7296418 0.816 rs1790096 chr12:123710364 C/T cg00376283 chr12:123451042 ABCB9 0.67 9.59 0.51 6.84e-19 Platelet count; CESC cis rs473651 0.935 rs578510 chr2:239343140 C/T cg18131467 chr2:239335373 ASB1 1.03 21.24 0.79 3.76e-59 Multiple system atrophy; CESC cis rs34734847 0.766 rs3794214 chr12:121168245 C/T cg21892295 chr12:121157589 UNC119B 0.35 5.71 0.33 3.03e-8 Mean corpuscular volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18014789 chr12:123717788 C12orf65 -0.47 -6.41 -0.37 6.6e-10 Gut microbiota (bacterial taxa); CESC cis rs765787 0.530 rs2413786 chr15:45525394 C/A cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg18350739 chr11:68623251 NA 0.43 6.77 0.38 8.48e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11792861 0.926 rs72607166 chr9:111821530 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 5.4 0.31 1.48e-7 Menarche (age at onset); CESC cis rs9611565 0.649 rs5758344 chr22:41817685 G/A cg03806693 chr22:41940476 POLR3H 1.2 14.5 0.67 1.86e-35 Vitiligo; CESC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg17971929 chr21:40555470 PSMG1 -0.54 -7.0 -0.4 2.04e-11 Menarche (age at onset); CESC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg23978390 chr7:1156363 C7orf50 0.42 5.63 0.33 4.49e-8 Longevity;Endometriosis; CESC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg15445000 chr17:37608096 MED1 -0.41 -6.8 -0.39 6.8e-11 Glomerular filtration rate (creatinine); CESC cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg00255919 chr5:131827918 IRF1 0.35 5.2 0.3 3.91e-7 Breast cancer;Mosquito bite size; CESC cis rs7818688 1.000 rs16917224 chr8:96030110 T/C cg16049864 chr8:95962084 TP53INP1 0.61 5.74 0.33 2.58e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.98 0.34 7.35e-9 Tonsillectomy; CESC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg00310523 chr12:86230176 RASSF9 0.41 6.18 0.36 2.36e-9 Major depressive disorder; CESC cis rs7819412 1.000 rs7819412 chr8:11045161 A/G cg21775007 chr8:11205619 TDH 0.38 5.36 0.31 1.79e-7 Triglycerides; CESC cis rs2860975 0.905 rs10786182 chr10:96789775 C/T cg09036531 chr10:96991505 NA -0.36 -5.23 -0.31 3.42e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs72781680 0.706 rs72794290 chr2:23896106 A/T cg20701182 chr2:24300061 SF3B14 0.81 7.06 0.4 1.5e-11 Lymphocyte counts; CESC cis rs13385 0.769 rs34994530 chr5:139558669 C/T cg26211634 chr5:139558579 C5orf32 0.47 5.16 0.3 4.77e-7 Atrial fibrillation; CESC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.33 6.0 0.35 6.29e-9 Electroencephalogram traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23098168 chr1:109801427 CELSR2 0.5 7.05 0.4 1.51e-11 Fibrinogen levels; CESC trans rs561341 1.000 rs55959993 chr17:30254771 C/G cg20587970 chr11:113659929 NA -1.43 -17.6 -0.73 1.89e-46 Hip circumference adjusted for BMI; CESC trans rs6460942 0.591 rs10262667 chr7:12385391 C/T cg16269144 chr1:2003326 PRKCZ 0.52 6.26 0.36 1.54e-9 Coronary artery disease; CESC cis rs9948 0.786 rs62152783 chr2:97457389 T/A cg01990225 chr2:97406019 LMAN2L -0.92 -7.51 -0.42 9.04e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs2119480 0.762 rs401084 chr13:111310086 C/G cg02866700 chr13:111333333 CARS2 -0.37 -5.18 -0.3 4.32e-7 Diastolic blood pressure; CESC cis rs919433 1.000 rs919433 chr2:198166565 G/A cg03934865 chr2:198174659 NA -0.45 -6.7 -0.38 1.24e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs3126085 0.560 rs3120665 chr1:152316590 A/G cg03465714 chr1:152285911 FLG 0.42 5.05 0.3 8.42e-7 Atopic dermatitis; CESC cis rs72781680 1.000 rs12616899 chr2:24165235 A/G cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.54 7.95 0.44 5.39e-14 Intelligence (multi-trait analysis); CESC trans rs853679 0.599 rs202906 chr6:28011652 C/T cg06606381 chr12:133084897 FBRSL1 0.77 7.04 0.4 1.64e-11 Depression; CESC cis rs6674970 0.748 rs56299877 chr1:151115645 C/T cg11822372 chr1:151115635 SEMA6C -0.87 -12.11 -0.6 3.82e-27 Childhood ear infection; CESC cis rs9858542 0.953 rs9827021 chr3:49514764 C/A cg07274523 chr3:49395745 GPX1 0.66 8.05 0.44 2.82e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7267979 0.966 rs2261795 chr20:25263136 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.48 0.75 1.44e-49 Liver enzyme levels (alkaline phosphatase); CESC cis rs6582630 0.555 rs11182202 chr12:38476451 C/G cg26384229 chr12:38710491 ALG10B 0.71 10.82 0.55 7.82e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs7605827 0.930 rs13410044 chr2:15602535 A/G cg19274914 chr2:15703543 NA 0.36 6.42 0.37 6.2e-10 Educational attainment (years of education); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19586645 chr17:73266642 MIF4GD 0.53 6.93 0.39 3.16e-11 Gut microbiota (bacterial taxa); CESC cis rs2645694 0.651 rs2703144 chr4:77830505 C/G cg10057126 chr4:77819792 ANKRD56 0.6 8.46 0.46 1.86e-15 Emphysema distribution in smoking; CESC cis rs2549003 1.000 rs7734334 chr5:131815004 C/A cg02551604 chr5:131831745 NA -0.36 -5.08 -0.3 7.22e-7 Asthma (sex interaction); CESC cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg03433033 chr1:76189801 ACADM 0.72 10.0 0.52 3.53e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs854765 0.929 rs2955360 chr17:17974887 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.46 -5.95 -0.34 8.48e-9 Total body bone mineral density; CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg07092213 chr7:1199455 ZFAND2A -0.45 -5.92 -0.34 1e-8 Longevity;Endometriosis; CESC cis rs7089973 0.585 rs7907837 chr10:116610690 G/T cg23260525 chr10:116636907 FAM160B1 0.43 8.28 0.45 6.14e-15 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg09359103 chr1:154839909 KCNN3 -0.68 -13.03 -0.62 2.48e-30 Prostate cancer; CESC cis rs854765 0.964 rs854813 chr17:18003845 C/T cg09796270 chr17:17721594 SREBF1 -0.38 -5.13 -0.3 5.62e-7 Total body bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11769841 chr22:38795061 LOC400927 0.44 6.51 0.37 3.79e-10 Gut microbiota (bacterial taxa); CESC cis rs10751667 0.961 rs7943115 chr11:973885 T/C cg06064525 chr11:970664 AP2A2 -0.36 -6.32 -0.36 1.09e-9 Alzheimer's disease (late onset); CESC cis rs8180040 0.620 rs11715121 chr3:47072621 T/A cg27129171 chr3:47204927 SETD2 -0.66 -9.82 -0.52 1.32e-19 Colorectal cancer; CESC cis rs6502050 0.835 rs4789731 chr17:80145904 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.25 -0.31 3.18e-7 Life satisfaction; CESC cis rs12681288 0.754 rs4735975 chr8:1000470 T/C cg15309053 chr8:964076 NA 0.32 5.46 0.32 1.11e-7 Schizophrenia; CESC cis rs644799 0.562 rs515546 chr11:95588756 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.47 6.06 0.35 4.71e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7582720 1.000 rs72926782 chr2:203811628 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs708547 0.874 rs1315006 chr4:57858193 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.71 7.63 0.42 4.22e-13 Response to bleomycin (chromatid breaks); CESC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg18446336 chr7:2847575 GNA12 -0.37 -5.71 -0.33 3e-8 Height; CESC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg06634786 chr22:41940651 POLR3H 0.69 6.8 0.39 6.88e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs2380220 0.720 rs9398251 chr6:95984709 C/T cg15832292 chr6:96025679 MANEA 0.61 6.85 0.39 5.26e-11 Behavioural disinhibition (generation interaction); CESC cis rs722599 0.639 rs12882676 chr14:75272433 A/G cg08847533 chr14:75593920 NEK9 0.46 5.63 0.33 4.66e-8 IgG glycosylation; CESC cis rs1153858 1.000 rs4395020 chr15:45652889 A/C cg21132104 chr15:45694354 SPATA5L1 0.86 11.64 0.58 1.49e-25 Homoarginine levels; CESC cis rs17539620 0.624 rs871068 chr6:154837514 C/A cg17771515 chr6:154831774 CNKSR3 0.59 5.85 0.34 1.43e-8 Lipoprotein (a) levels; CESC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg18876405 chr7:65276391 NA -0.53 -7.16 -0.4 7.93e-12 Aortic root size; CESC cis rs8060686 0.641 rs1074143 chr16:68127278 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 4.92e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs9300255 0.739 rs1980252 chr12:123745178 C/G cg19016782 chr12:123741754 C12orf65 -0.5 -7.26 -0.41 4.23e-12 Neutrophil percentage of white cells; CESC cis rs11864453 0.713 rs7191127 chr16:72123992 G/T cg01557791 chr16:72042693 DHODH -0.46 -5.92 -0.34 9.98e-9 Fibrinogen levels; CESC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg24250549 chr1:154909240 PMVK 0.74 11.08 0.56 1.06e-23 Prostate cancer; CESC cis rs116095464 0.558 rs10058428 chr5:235608 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.23 0.31 3.39e-7 Breast cancer; CESC trans rs9858542 1.000 rs11718165 chr3:49696797 A/G cg21659725 chr3:3221576 CRBN -0.54 -6.47 -0.37 4.79e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2408955 0.522 rs10875721 chr12:48413593 A/G cg04545296 chr12:48745243 ZNF641 -0.35 -5.89 -0.34 1.17e-8 Glycated hemoglobin levels; CESC cis rs4319547 0.661 rs10773172 chr12:122939655 G/A cg05707623 chr12:122985044 ZCCHC8 -0.5 -6.31 -0.36 1.19e-9 Body mass index; CESC cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg25405998 chr7:65216604 CCT6P1 0.51 5.46 0.32 1.09e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01509715 chr16:31073567 ZNF668 0.47 6.12 0.35 3.28e-9 Fibrinogen levels; CESC cis rs4242434 0.854 rs3735893 chr8:22452704 A/G cg03733263 chr8:22462867 KIAA1967 0.87 14.03 0.65 8.13e-34 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.36 -6.77 -0.38 8.3e-11 Bipolar disorder; CESC cis rs79349575 0.783 rs4794000 chr17:47022755 C/G cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs35110281 0.720 rs162393 chr21:44942692 G/A cg21573476 chr21:45109991 RRP1B -0.41 -5.72 -0.33 2.81e-8 Mean corpuscular volume; CESC cis rs2425143 1.000 rs11696369 chr20:34378629 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.79 -0.43 1.54e-13 Blood protein levels; CESC cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg02297831 chr4:17616191 MED28 0.61 7.82 0.43 1.26e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9527 0.590 rs3740386 chr10:104931051 C/T cg04362960 chr10:104952993 NT5C2 0.42 5.25 0.31 3.09e-7 Arsenic metabolism; CESC trans rs4332037 0.552 rs11773627 chr7:2002733 A/G cg11693508 chr17:37793320 STARD3 0.64 6.49 0.37 4.29e-10 Bipolar disorder; CESC cis rs2952156 0.920 rs9675194 chr17:37833805 A/G cg20243544 chr17:37824526 PNMT 0.64 8.63 0.47 5.86e-16 Asthma; CESC cis rs3820928 0.874 rs2229813 chr2:227892720 C/T cg05526886 chr2:227700861 RHBDD1 -0.45 -5.82 -0.34 1.71e-8 Pulmonary function; CESC cis rs4822044 0.561 rs132781 chr22:42046122 T/G cg06634786 chr22:41940651 POLR3H 0.59 5.93 0.34 9.66e-9 Cannabis dependence symptom count; CESC cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.27e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2072499 1.000 rs2540173 chr1:156188214 A/G cg24450063 chr1:156163899 SLC25A44 1.08 21.15 0.79 8.02e-59 Testicular germ cell tumor; CESC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs2979489 0.773 rs2915617 chr8:30272310 C/G cg26383811 chr8:30366931 RBPMS 0.51 6.48 0.37 4.4e-10 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs476633 0.691 rs28568756 chr15:41539371 G/A cg18705301 chr15:41695430 NDUFAF1 -0.47 -6.94 -0.39 3.01e-11 Glomerular filtration rate (creatinine); CESC trans rs11098499 0.954 rs3733519 chr4:120423448 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.85 0.52 1.03e-19 Corneal astigmatism; CESC cis rs7274811 0.554 rs35556109 chr20:32133489 G/A cg21523528 chr20:32077966 CBFA2T2 0.63 7.25 0.41 4.68e-12 Height; CESC cis rs1580019 0.587 rs6951955 chr7:32548761 A/T cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.39 0.37 7.42e-10 Cognitive ability; CESC cis rs2235642 0.717 rs9937922 chr16:1658154 C/G cg03771183 chr16:1608904 IFT140 0.4 5.91 0.34 1.04e-8 Coronary artery disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15645344 chr4:165109574 MARCH1 -0.45 -6.13 -0.35 3.21e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs35096708 1.000 rs35096708 chr16:89887249 G/A cg04287289 chr16:89883240 FANCA -0.52 -5.81 -0.34 1.76e-8 Skin aging (microtopography measurement); CESC cis rs18122 0.846 rs11885548 chr2:67628593 G/A cg09028215 chr2:67624308 ETAA1 -0.43 -5.28 -0.31 2.73e-7 Waist-to-hip ratio adjusted for body mass index; CESC trans rs1814175 0.754 rs28663627 chr11:50048829 C/T cg15704280 chr7:45808275 SEPT13 -1.06 -21.45 -0.8 7.56e-60 Height; CESC cis rs10465746 0.967 rs12140068 chr1:84394286 A/C cg10977910 chr1:84465055 TTLL7 0.46 6.32 0.36 1.13e-9 Obesity-related traits; CESC cis rs7914558 1.000 rs11191541 chr10:104824199 A/G cg08650961 chr10:104748594 CNNM2 0.31 5.19 0.3 4.18e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg04166393 chr7:2884313 GNA12 -0.6 -8.23 -0.45 8.48e-15 Height; CESC cis rs6964587 0.692 rs10271430 chr7:91710466 G/C cg01689657 chr7:91764605 CYP51A1 0.27 5.28 0.31 2.64e-7 Breast cancer; CESC cis rs9970334 0.596 rs709209 chr1:6278414 A/G cg15892785 chr1:6309343 GPR153 -0.62 -9.02 -0.48 4.04e-17 Resting heart rate; CESC cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg05347473 chr6:146136440 FBXO30 -0.57 -7.36 -0.41 2.27e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7914558 1.000 rs1890184 chr10:104748459 A/C cg15744005 chr10:104629667 AS3MT -0.34 -5.51 -0.32 8.51e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12220238 0.730 rs11000899 chr10:75913055 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.65 6.18 0.36 2.35e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs6598955 0.670 rs6598942 chr1:26531034 C/T cg00852783 chr1:26633632 UBXN11 0.41 5.9 0.34 1.09e-8 Obesity-related traits; CESC cis rs62408225 1.000 rs17513415 chr6:90947867 C/T cg06866423 chr6:90926672 BACH2 0.49 5.9 0.34 1.13e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs10865541 0.571 rs4854187 chr2:3384196 C/G cg11855769 chr2:3383351 TTC15 -0.44 -5.41 -0.32 1.4e-7 Obesity-related traits; CESC cis rs10089 0.953 rs1036171 chr5:127402798 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.17 0.53 9.96e-21 Ileal carcinoids; CESC cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.38 5.47 0.32 1.02e-7 Schizophrenia; CESC cis rs4689388 0.581 rs4476672 chr4:6281496 A/G cg00701064 chr4:6280414 WFS1 0.61 7.51 0.42 8.84e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs858239 0.601 rs4599714 chr7:23168801 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.73 0.43 2.27e-13 Cerebrospinal fluid biomarker levels; CESC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg20887711 chr4:1340912 KIAA1530 0.84 11.4 0.57 9.5e-25 Longevity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01228352 chr3:150329615 SELT 0.47 6.28 0.36 1.37e-9 Fibrinogen levels; CESC cis rs12142240 0.698 rs17361763 chr1:46810670 T/C cg00530320 chr1:46809349 NSUN4 0.6 7.97 0.44 4.86e-14 Menopause (age at onset); CESC cis rs1538970 0.781 rs10890330 chr1:45920406 G/A cg03146154 chr1:46216737 IPP 0.47 5.44 0.32 1.23e-7 Platelet count; CESC cis rs7937682 0.632 rs57414412 chr11:111769431 G/A cg09085632 chr11:111637200 PPP2R1B 0.87 11.02 0.56 1.67e-23 Primary sclerosing cholangitis; CESC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg11965913 chr1:205819406 PM20D1 0.83 13.0 0.62 3.29e-30 Menarche (age at onset); CESC cis rs2070488 0.699 rs6599205 chr3:38529440 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.77 11.72 0.58 7.5e-26 Electrocardiographic conduction measures; CESC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg01017244 chr2:74357527 NA 0.77 9.87 0.52 9.02e-20 Gestational age at birth (maternal effect); CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg09033563 chr22:24373618 LOC391322 0.44 5.77 0.33 2.25e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg20243544 chr17:37824526 PNMT -0.44 -5.45 -0.32 1.13e-7 Glomerular filtration rate (creatinine); CESC cis rs4253772 0.678 rs9627281 chr22:46644168 A/G cg09491104 chr22:46646882 C22orf40 -0.56 -8.71 -0.47 3.38e-16 LDL cholesterol;Cholesterol, total; CESC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg04414720 chr1:150670196 GOLPH3L 0.55 7.44 0.42 1.37e-12 Melanoma; CESC cis rs6032067 0.929 rs6032070 chr20:43869795 A/T cg10761708 chr20:43804764 PI3 0.5 6.06 0.35 4.71e-9 Blood protein levels; CESC cis rs7818688 0.578 rs4355737 chr8:95827173 C/T cg16049864 chr8:95962084 TP53INP1 0.56 5.65 0.33 4.24e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.2e-17 Prudent dietary pattern; CESC cis rs2228479 0.850 rs62056102 chr16:89941438 T/C cg14709524 chr16:89940631 TCF25 0.88 6.44 0.37 5.5e-10 Skin colour saturation; CESC cis rs7937682 0.737 rs682239 chr11:111425105 A/G cg09085632 chr11:111637200 PPP2R1B 0.75 10.16 0.53 1.1e-20 Primary sclerosing cholangitis; CESC trans rs9929218 1.000 rs28549017 chr16:68758828 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -9.72 -0.51 2.7e-19 Colorectal cancer; CESC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg26335602 chr6:28129616 ZNF389 0.49 6.74 0.38 9.99e-11 Depression; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02470565 chr22:29702866 GAS2L1 -0.48 -6.01 -0.35 6.09e-9 Ulcerative colitis; CESC cis rs1448094 0.654 rs7133797 chr12:86294184 G/C cg02569458 chr12:86230093 RASSF9 0.36 5.14 0.3 5.46e-7 Major depressive disorder; CESC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.05e-8 Lung cancer; CESC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.73 9.48 0.5 1.53e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7949030 0.588 rs2512562 chr11:62312156 A/G cg13298116 chr11:62369859 EML3;MTA2 0.58 8.58 0.47 8.21e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7903847 0.642 rs11189204 chr10:99164394 C/T cg20016023 chr10:99160130 RRP12 -0.3 -5.19 -0.3 4.12e-7 Granulocyte percentage of myeloid white cells; CESC cis rs1669338 0.588 rs73009149 chr3:3220473 G/C cg16797762 chr3:3221439 CRBN -0.53 -5.18 -0.3 4.5e-7 White matter integrity; CESC cis rs1801251 1.000 rs2675974 chr2:233727071 A/G cg08000102 chr2:233561755 GIGYF2 0.66 9.67 0.51 3.91e-19 Coronary artery disease; CESC cis rs2742234 0.955 rs2435385 chr10:43665750 A/G cg15436174 chr10:43711423 RASGEF1A -0.43 -5.44 -0.32 1.2e-7 Hirschsprung disease; CESC cis rs3020736 0.500 rs6002614 chr22:42501802 G/A cg15557168 chr22:42548783 NA 0.45 6.51 0.37 3.78e-10 Autism spectrum disorder or schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg27194998 chr19:47217554 PRKD2 -0.51 -6.41 -0.37 6.52e-10 Ulcerative colitis; CESC cis rs722599 0.683 rs8022046 chr14:75278302 G/A cg11812906 chr14:75593930 NEK9 0.45 5.44 0.32 1.24e-7 IgG glycosylation; CESC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg08888203 chr3:10149979 C3orf24 0.49 5.5 0.32 8.81e-8 Alzheimer's disease; CESC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg19077165 chr18:44547161 KATNAL2 -0.55 -7.89 -0.44 8.21e-14 Personality dimensions; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23567369 chr14:24036565 AP1G2 -0.48 -6.4 -0.37 6.85e-10 Fibrinogen levels; CESC cis rs62103177 0.810 rs62096746 chr18:77619556 T/A cg12964065 chr18:77638022 KCNG2 0.58 5.68 0.33 3.5e-8 Opioid sensitivity; CESC cis rs6695640 0.819 rs2800697 chr1:17731751 C/T cg01904812 chr1:17746340 RCC2 0.36 5.26 0.31 2.97e-7 Mean platelet volume; CESC cis rs6754311 0.509 rs10188066 chr2:136539513 G/A cg07169764 chr2:136633963 MCM6 -0.72 -9.3 -0.5 5.58e-18 Mosquito bite size; CESC cis rs6063312 0.935 rs6066827 chr20:47341005 T/C cg18078177 chr20:47281410 PREX1 0.56 5.7 0.33 3.2e-8 Tonometry; CESC cis rs6582630 0.547 rs1589388 chr12:38416025 C/T cg26384229 chr12:38710491 ALG10B -0.44 -5.99 -0.35 6.77e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs1879734 0.731 rs10888805 chr1:54160571 A/G cg23596471 chr1:54105337 GLIS1 0.35 5.66 0.33 3.96e-8 Mitral valve prolapse; CESC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg02772935 chr3:125709198 NA -0.47 -5.5 -0.32 8.75e-8 Blood pressure (smoking interaction); CESC cis rs4595586 0.545 rs61939641 chr12:39378001 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs3733418 0.799 rs35680343 chr4:165953134 T/G cg10852876 chr4:165953100 TRIM60 -0.48 -5.76 -0.33 2.31e-8 Obesity-related traits; CESC cis rs6752107 0.967 rs36001488 chr2:234185267 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.69 0.38 1.3e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.31e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11122272 0.525 rs2739517 chr1:231537914 C/A cg06096015 chr1:231504339 EGLN1 0.43 6.08 0.35 4.28e-9 Hemoglobin concentration; CESC cis rs55871839 0.559 rs7834158 chr8:59843813 C/A cg07426533 chr8:59803705 TOX 0.4 5.28 0.31 2.73e-7 Pneumonia; CESC cis rs4555082 0.834 rs2735822 chr14:105712734 C/T cg06808227 chr14:105710500 BRF1 -0.51 -5.65 -0.33 4.08e-8 Mean platelet volume;Platelet distribution width; CESC cis rs722599 0.748 rs61978948 chr14:75363369 G/A cg08847533 chr14:75593920 NEK9 -0.46 -5.49 -0.32 9.57e-8 IgG glycosylation; CESC cis rs4409675 0.576 rs2815707 chr1:28238880 T/C cg23691781 chr1:28212827 C1orf38 0.28 5.59 0.32 5.61e-8 Corneal astigmatism; CESC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg07395648 chr5:131743802 NA -0.43 -5.74 -0.33 2.6e-8 Acylcarnitine levels; CESC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg04369109 chr6:150039330 LATS1 -0.39 -5.38 -0.31 1.63e-7 Lung cancer; CESC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg23978390 chr7:1156363 C7orf50 -0.52 -6.71 -0.38 1.2e-10 Longevity;Endometriosis; CESC cis rs524281 0.861 rs3953856 chr11:65965908 T/A cg14036092 chr11:66035641 RAB1B -0.6 -6.1 -0.35 3.77e-9 Electroencephalogram traits; CESC cis rs7666738 0.830 rs1869897 chr4:98730997 C/T cg17366294 chr4:99064904 C4orf37 0.55 7.43 0.42 1.47e-12 Colonoscopy-negative controls vs population controls; CESC cis rs12618769 0.597 rs12617721 chr2:99083892 G/T cg10123293 chr2:99228465 UNC50 -0.4 -5.45 -0.32 1.18e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17881958 chr10:50747314 ERCC6 0.61 6.56 0.37 2.79e-10 Gut microbiome composition (summer); CESC cis rs9291683 0.595 rs13145442 chr4:10037261 C/A cg11266682 chr4:10021025 SLC2A9 0.7 13.8 0.65 5.02e-33 Bone mineral density; CESC cis rs9660992 0.573 rs1172158 chr1:205208948 G/A cg21643547 chr1:205240462 TMCC2 -0.39 -5.37 -0.31 1.76e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs7648466 0.544 rs2172247 chr3:46214670 T/C cg08033130 chr3:45983597 CXCR6;FYCO1 0.37 5.16 0.3 4.77e-7 Eotaxin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22857999 chr1:24127039 GALE 0.58 6.48 0.37 4.53e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.649 rs5758442 chr22:42133060 T/C cg03806693 chr22:41940476 POLR3H 0.78 9.54 0.51 9.81e-19 Vitiligo; CESC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg08859206 chr1:53392774 SCP2 -0.65 -9.31 -0.5 5.23e-18 Monocyte count; CESC cis rs7647973 0.626 rs1586827 chr3:49671224 T/C cg06212747 chr3:49208901 KLHDC8B 0.64 7.69 0.43 2.83e-13 Menarche (age at onset); CESC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg12311346 chr5:56204834 C5orf35 -0.74 -8.87 -0.48 1.09e-16 Initial pursuit acceleration; CESC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg12311346 chr5:56204834 C5orf35 -0.64 -8.78 -0.47 2.01e-16 Initial pursuit acceleration; CESC cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.69 6.62 0.38 2e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs6674176 0.597 rs12127737 chr1:44402565 G/A cg13606994 chr1:44402422 ARTN -0.41 -6.52 -0.37 3.47e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 6.8 0.39 6.75e-11 Electroencephalogram traits; CESC cis rs11696501 0.694 rs6130870 chr20:44263263 T/C cg11783356 chr20:44313418 WFDC10B -0.34 -5.29 -0.31 2.54e-7 Brain structure; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg00405494 chr9:7797524 C9orf123 0.51 6.08 0.35 4.23e-9 Lung cancer in ever smokers; CESC cis rs12477438 0.765 rs2309454 chr2:99595418 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs703842 1.000 rs11172351 chr12:58213485 C/T cg00677455 chr12:58241039 CTDSP2 0.55 7.1 0.4 1.18e-11 Multiple sclerosis; CESC cis rs2304069 0.545 rs12153714 chr5:149395254 A/G cg12661370 chr5:149340060 SLC26A2 0.43 5.67 0.33 3.75e-8 HIV-1 control; CESC cis rs796364 0.951 rs12620298 chr2:201047184 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.62 -5.91 -0.34 1.05e-8 Schizophrenia; CESC cis rs748404 0.697 rs554001 chr15:43551919 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.09 0.44 2.22e-14 Lung cancer; CESC cis rs11078597 0.731 rs12944946 chr17:1649486 C/G cg18436246 chr17:1640651 WDR81 0.62 7.63 0.42 4.25e-13 Serum albumin level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09820183 chr1:222886073 C1orf58;AIDA 0.56 6.79 0.38 7.3e-11 Gut microbiome composition (summer); CESC cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg16850897 chr7:100343110 ZAN -0.58 -6.23 -0.36 1.83e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8014204 0.762 rs10139018 chr14:75274292 T/C cg08847533 chr14:75593920 NEK9 0.4 5.15 0.3 5.11e-7 Caffeine consumption; CESC cis rs3845702 0.866 rs3914458 chr2:180862606 A/G cg01881094 chr2:180872142 CWC22 -0.66 -7.11 -0.4 1.05e-11 Schizophrenia; CESC cis rs826838 0.809 rs11169666 chr12:39211300 T/C cg13010199 chr12:38710504 ALG10B 0.59 8.25 0.45 7.6e-15 Heart rate; CESC cis rs6887276 0.538 rs35897671 chr5:127349745 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.45 -5.56 -0.32 6.52e-8 Height; CESC cis rs9858542 0.953 rs11710037 chr3:49675334 C/G cg03060546 chr3:49711283 APEH -0.57 -6.68 -0.38 1.42e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs317689 0.918 rs689415 chr12:69738139 A/G cg14784868 chr12:69753453 YEATS4 -0.64 -7.26 -0.41 4.35e-12 Response to diuretic therapy; CESC cis rs75477785 0.590 rs79880650 chr1:209913916 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.84 5.39 0.31 1.54e-7 Cleft lip with or without cleft palate; CESC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg24549020 chr5:56110836 MAP3K1 0.64 7.38 0.41 2.08e-12 Initial pursuit acceleration; CESC cis rs7267979 0.933 rs2387887 chr20:25427081 G/T cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.4e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg27266027 chr21:40555129 PSMG1 0.45 5.3 0.31 2.47e-7 Cognitive function; CESC cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg09323728 chr8:95962352 TP53INP1 0.35 6.18 0.36 2.34e-9 Type 2 diabetes; CESC cis rs6942756 1.000 rs2103232 chr7:128951232 G/T cg02491457 chr7:128862824 NA -0.68 -9.28 -0.5 6.2e-18 White matter hyperintensity burden; CESC cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg22862634 chr11:62369728 EML3;MTA2 0.6 8.48 0.46 1.58e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14182682 chr14:57857589 NAA30 -0.45 -6.1 -0.35 3.77e-9 Gut microbiota (bacterial taxa); CESC trans rs116095464 0.681 rs10060016 chr5:241100 T/C cg00938859 chr5:1591904 SDHAP3 0.64 6.98 0.39 2.36e-11 Breast cancer; CESC cis rs736801 0.808 rs6866614 chr5:131787137 A/G cg21138405 chr5:131827807 IRF1 0.39 5.66 0.33 3.88e-8 Breast cancer;Mosquito bite size; CESC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg22907277 chr7:1156413 C7orf50 0.47 5.3 0.31 2.48e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs295137 0.798 rs1900706 chr2:201214071 A/C cg23649088 chr2:200775458 C2orf69 0.41 5.32 0.31 2.26e-7 Asthma (bronchodilator response); CESC cis rs1580019 0.961 rs11768506 chr7:32494788 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.72 10.07 0.53 2.04e-20 Cognitive ability; CESC cis rs7107174 0.892 rs7115850 chr11:78045071 C/G cg02023728 chr11:77925099 USP35 0.38 5.45 0.32 1.14e-7 Testicular germ cell tumor; CESC cis rs7580658 0.857 rs17015199 chr2:128094053 A/G cg10021288 chr2:128175891 PROC -0.41 -6.37 -0.36 8.11e-10 Protein C levels; CESC cis rs2154427 0.938 rs113791275 chr21:34202806 A/C cg21871883 chr21:34145043 C21orf49;C21orf66 0.62 5.15 0.3 5.15e-7 Bilirubin levels; CESC cis rs71403859 0.730 rs17347255 chr16:71587225 C/T cg08717414 chr16:71523259 ZNF19 -0.84 -7.51 -0.42 9.26e-13 Post bronchodilator FEV1; CESC cis rs116095464 0.558 rs10076655 chr5:239464 G/C cg10591111 chr5:226296 SDHA -0.51 -6.26 -0.36 1.53e-9 Breast cancer; CESC trans rs3780486 0.846 rs3780490 chr9:33129839 A/G cg20290983 chr6:43655470 MRPS18A 0.99 18.34 0.75 4.45e-49 IgG glycosylation; CESC cis rs9815354 0.761 rs12186109 chr3:41836920 T/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7267979 1.000 rs1047171 chr20:25428786 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 3e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs714031 0.902 rs4820388 chr22:40070642 C/G cg21377881 chr22:40064566 CACNA1I -0.35 -5.75 -0.33 2.49e-8 Schizophrenia; CESC trans rs73242632 1.000 rs12511480 chr4:57748143 C/T cg16182707 chr12:105478090 ALDH1L2 0.72 6.05 0.35 4.88e-9 Congenital heart disease (maternal effect); CESC trans rs7944735 0.507 rs7114598 chr11:48101766 C/T cg03929089 chr4:120376271 NA 0.55 6.53 0.37 3.38e-10 Intraocular pressure; CESC cis rs7072216 0.763 rs6584200 chr10:100170037 A/G cg26618903 chr10:100175079 PYROXD2 -0.37 -5.76 -0.33 2.33e-8 Metabolite levels; CESC cis rs7089973 0.966 rs55711292 chr10:116604870 T/G cg25233709 chr10:116636983 FAM160B1 0.38 5.49 0.32 9.46e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6445797 0.662 rs17216671 chr3:56582551 C/G cg13792233 chr3:56591045 CCDC66 -0.39 -5.11 -0.3 6.19e-7 Gastritis; CESC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg17211192 chr8:82754475 SNX16 -0.52 -6.64 -0.38 1.73e-10 Diastolic blood pressure; CESC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg10053473 chr17:62856997 LRRC37A3 0.65 7.33 0.41 2.74e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.82 0.59 3.55e-26 Platelet count; CESC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg10053473 chr17:62856997 LRRC37A3 -0.6 -6.63 -0.38 1.84e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg11366901 chr6:160182831 ACAT2 0.76 9.51 0.5 1.21e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs9929218 1.000 rs4783570 chr16:68806539 G/T cg02972257 chr16:68554789 NA 0.43 5.12 0.3 5.89e-7 Colorectal cancer; CESC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg00484396 chr16:3507460 NAT15 -0.58 -6.29 -0.36 1.32e-9 Tuberculosis; CESC cis rs77741769 0.571 rs11065324 chr12:121346795 C/G cg02419362 chr12:121203948 SPPL3 -0.34 -5.5 -0.32 8.83e-8 Mean corpuscular volume; CESC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg02398342 chr17:80708632 TBCD;FN3K 0.43 5.09 0.3 6.66e-7 Glycated hemoglobin levels; CESC cis rs1878931 0.507 rs8054222 chr16:3413477 C/T cg22508957 chr16:3507546 NAT15 0.38 5.2 0.3 3.96e-7 Body mass index (adult); CESC cis rs7555523 1.000 rs7555523 chr1:165718979 C/A cg24409356 chr1:165738333 TMCO1 0.92 8.21 0.45 9.56e-15 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs1256061 0.603 rs1256041 chr14:64738029 A/G cg21174375 chr14:64681225 SYNE2 0.51 6.82 0.39 6.15e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg21251018 chr6:28226885 NKAPL 0.37 6.21 0.36 2.04e-9 Cardiac Troponin-T levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26681016 chr1:43424924 SLC2A1 0.64 7.57 0.42 6.09e-13 Gut microbiome composition (summer); CESC cis rs2425143 0.514 rs8114246 chr20:34581979 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -5.77 -0.33 2.18e-8 Blood protein levels; CESC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg23048001 chr7:2026167 MAD1L1 0.4 5.17 0.3 4.54e-7 Bipolar disorder and schizophrenia; CESC cis rs9902453 0.845 rs116840018 chr17:28232049 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.2 0.45 1.05e-14 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04865506 chr17:29422776 NF1 -0.52 -6.03 -0.35 5.47e-9 Gut microbiome composition (summer); CESC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg06505273 chr16:24850292 NA 0.51 6.1 0.35 3.64e-9 Intelligence (multi-trait analysis); CESC cis rs12474201 0.928 rs13025984 chr2:46938789 T/C cg06386533 chr2:46925753 SOCS5 0.92 12.74 0.62 2.57e-29 Height; CESC trans rs60843830 0.928 rs55742348 chr2:217563 T/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 7.99 0.44 4.26e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs2946505 0.516 rs2954193 chr8:12818373 T/C cg09851072 chr16:4749498 ANKS3 -0.62 -6.01 -0.35 6.19e-9 Migraine; CESC cis rs6540556 0.769 rs6540553 chr1:209929044 C/G cg05527609 chr1:210001259 C1orf107 -0.47 -5.73 -0.33 2.7e-8 Red blood cell count; CESC cis rs11920090 0.860 rs7638998 chr3:170741015 A/G cg09710316 chr3:170744871 SLC2A2 0.43 5.16 0.3 4.81e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs10504229 0.773 rs60466370 chr8:58171248 A/C cg22535103 chr8:58192502 C8orf71 -0.87 -11.17 -0.57 5.43e-24 Developmental language disorder (linguistic errors); CESC cis rs7223966 1.000 rs16947042 chr17:61766457 T/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.35 -0.31 1.9e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7772486 0.875 rs2492855 chr6:146296926 A/G cg05347473 chr6:146136440 FBXO30 0.48 6.56 0.37 2.89e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9908102 0.740 rs58700278 chr17:12907128 A/C cg26162695 chr17:12921313 ELAC2 0.51 5.86 0.34 1.37e-8 Schizophrenia; CESC trans rs11264799 0.765 rs67805319 chr1:157622853 G/A cg22691776 chr3:15032403 NR2C2 0.33 6.1 0.35 3.7e-9 IgA nephropathy; CESC cis rs4950322 0.570 rs76236344 chr1:146769674 G/A cg22381352 chr1:146742008 CHD1L -0.46 -5.05 -0.3 8.32e-7 Protein quantitative trait loci; CESC cis rs2235642 0.928 rs1057610 chr16:1605537 T/C cg09080909 chr16:1797204 MAPK8IP3 -0.37 -5.08 -0.3 7.16e-7 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14588027 chr1:212872986 BATF3 -0.39 -5.99 -0.35 6.71e-9 Gambling; CESC cis rs2832191 0.720 rs2832194 chr21:30494250 T/C cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.63e-20 Dental caries; CESC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg26338869 chr17:61819248 STRADA 0.69 9.18 0.49 1.23e-17 Prudent dietary pattern; CESC cis rs2963155 0.518 rs712189 chr5:142631258 C/T cg17617527 chr5:142782415 NR3C1 0.83 7.26 0.41 4.29e-12 Breast cancer; CESC cis rs9457247 1.000 rs2769354 chr6:167379771 G/T cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.62e-7 Crohn's disease; CESC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg20503657 chr10:835505 NA 0.67 6.11 0.35 3.56e-9 Eosinophil percentage of granulocytes; CESC trans rs11098499 0.644 rs2389880 chr4:120559870 T/A cg25214090 chr10:38739885 LOC399744 0.64 9.04 0.49 3.3e-17 Corneal astigmatism; CESC cis rs7656342 0.686 rs1401440 chr4:9832512 C/T cg11266682 chr4:10021025 SLC2A9 0.33 5.26 0.31 3e-7 Gut microbiota (bacterial taxa); CESC cis rs7605827 0.930 rs7608831 chr2:15605029 A/G cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs3008870 0.917 rs12044492 chr1:67461667 T/C cg02640540 chr1:67518911 SLC35D1 -0.51 -5.58 -0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs3733585 0.736 rs4543113 chr4:10008305 G/A cg11266682 chr4:10021025 SLC2A9 0.66 12.55 0.61 1.14e-28 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg15017067 chr4:17643749 FAM184B 0.37 5.2 0.3 3.95e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6430585 0.878 rs9677760 chr2:136538939 T/A cg07169764 chr2:136633963 MCM6 -0.96 -13.08 -0.63 1.64e-30 Corneal structure; CESC cis rs17407555 0.821 rs17198197 chr4:10139157 A/G cg00071950 chr4:10020882 SLC2A9 0.61 5.49 0.32 9.37e-8 Schizophrenia (age at onset); CESC cis rs3733585 0.725 rs10939636 chr4:9972640 T/G cg02734326 chr4:10020555 SLC2A9 -0.42 -5.86 -0.34 1.39e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1023500 0.551 rs133355 chr22:42440285 G/A cg04733989 chr22:42467013 NAGA 0.8 11.74 0.59 6.47e-26 Schizophrenia; CESC cis rs74181299 0.712 rs2241160 chr2:65291546 A/G cg05010058 chr2:65284262 CEP68 0.31 5.19 0.3 4.24e-7 Pulse pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04382627 chr10:134351046 INPP5A 0.62 7.12 0.4 1.04e-11 Gut microbiome composition (summer); CESC cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg00376283 chr12:123451042 ABCB9 -0.62 -8.06 -0.44 2.66e-14 Height;Educational attainment;Head circumference (infant); CESC cis rs7107174 1.000 rs114142124 chr11:78047537 T/C cg02023728 chr11:77925099 USP35 0.48 6.16 0.35 2.71e-9 Testicular germ cell tumor; CESC cis rs793571 0.502 rs688756 chr15:59076272 A/C cg05156742 chr15:59063176 FAM63B 0.78 11.19 0.57 4.54e-24 Schizophrenia; CESC cis rs7267979 0.966 rs6083855 chr20:25405118 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -17.76 -0.74 5.21e-47 Liver enzyme levels (alkaline phosphatase); CESC cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg26769984 chr7:1090371 C7orf50 0.67 7.83 0.43 1.16e-13 Bronchopulmonary dysplasia; CESC cis rs858239 0.539 rs6461695 chr7:23197784 C/A cg23682824 chr7:23144976 KLHL7 0.44 5.8 0.34 1.88e-8 Cerebrospinal fluid biomarker levels; CESC cis rs1009170 1.000 rs1009170 chr14:92636713 A/T cg10324096 chr14:92587714 CPSF2;NDUFB1 -0.46 -5.15 -0.3 5.14e-7 Dialysis-related mortality; CESC cis rs17376456 0.877 rs66696214 chr5:93424533 G/A cg21475434 chr5:93447410 FAM172A 0.88 7.67 0.43 3.29e-13 Diabetic retinopathy; CESC cis rs9303280 0.806 rs11870965 chr17:38030205 T/A cg20243544 chr17:37824526 PNMT 0.5 6.43 0.37 5.86e-10 Self-reported allergy; CESC cis rs1949733 0.523 rs62287455 chr4:8544994 A/T cg11789530 chr4:8429930 ACOX3 -0.56 -7.03 -0.4 1.79e-11 Response to antineoplastic agents; CESC cis rs155076 1.000 rs566364 chr13:21837583 T/C cg11317459 chr13:21872234 NA -1.01 -10.78 -0.55 1.07e-22 White matter hyperintensity burden; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17274881 chr4:79103244 FRAS1 -0.44 -6.26 -0.36 1.53e-9 Gut microbiota (bacterial taxa); CESC cis rs8135665 0.625 rs34385006 chr22:38450291 C/T cg13116946 chr22:38479732 SLC16A8 0.42 5.14 0.3 5.31e-7 Advanced age-related macular degeneration;Age-related macular degeneration; CESC trans rs9858542 0.953 rs9853683 chr3:49512588 A/G cg21659725 chr3:3221576 CRBN -0.55 -6.49 -0.37 4.22e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26220061 chr1:70819839 HHLA3;ANKRD13C 0.57 6.16 0.35 2.75e-9 Gut microbiome composition (summer); CESC cis rs17433780 0.964 rs10493821 chr1:89475135 C/T cg09516651 chr1:89888402 LOC400759 0.69 9.44 0.5 2.04e-18 Carotid intima media thickness; CESC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg11764359 chr7:65958608 NA -0.78 -10.74 -0.55 1.44e-22 Aortic root size; CESC cis rs1707322 1.000 rs12124847 chr1:46380850 T/A cg05343316 chr1:45956843 TESK2 0.5 6.07 0.35 4.35e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs4843747 0.803 rs72818522 chr16:88059144 C/T cg06915872 chr16:87998081 BANP 0.5 5.89 0.34 1.17e-8 Menopause (age at onset); CESC cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg08085267 chr17:45401833 C17orf57 -0.43 -5.41 -0.32 1.41e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.32 -0.31 2.25e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs208520 0.754 rs851593 chr6:66875783 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.0 12.55 0.61 1.12e-28 Exhaled nitric oxide output; CESC cis rs4803468 0.763 rs17318596 chr19:41937095 A/G cg08639244 chr19:41945921 ATP5SL -0.44 -5.35 -0.31 1.92e-7 Height; CESC cis rs1348850 0.514 rs4893974 chr2:178497026 A/G cg22681709 chr2:178499509 PDE11A -0.45 -5.37 -0.31 1.69e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs854765 0.583 rs950966 chr17:17783748 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.53 -7.3 -0.41 3.29e-12 Total body bone mineral density; CESC cis rs854765 0.583 rs5002487 chr17:17832460 A/G cg09796270 chr17:17721594 SREBF1 0.43 6.12 0.35 3.39e-9 Total body bone mineral density; CESC cis rs4243830 0.850 rs4908911 chr1:6599523 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.86 -7.53 -0.42 7.77e-13 Body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08255233 chr6:87607178 NA -0.43 -6.68 -0.38 1.44e-10 Gut microbiota (bacterial taxa); CESC cis rs6460942 1.000 rs62448565 chr7:12400458 G/A cg02935154 chr7:12443704 VWDE -0.56 -6.06 -0.35 4.71e-9 Coronary artery disease; CESC cis rs796364 0.806 rs115717210 chr2:201006247 T/C cg23649088 chr2:200775458 C2orf69 -0.55 -5.04 -0.3 8.69e-7 Schizophrenia; CESC cis rs763121 0.962 rs6001159 chr22:38966487 A/G cg06544989 chr22:39130855 UNC84B 0.46 8.25 0.45 7.4e-15 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11539992 chr17:74497631 RHBDF2 -0.51 -6.48 -0.37 4.47e-10 Ulcerative colitis; CESC cis rs4689388 0.926 rs1801214 chr4:6303022 C/T cg00701064 chr4:6280414 WFS1 0.69 12.03 0.59 6.81e-27 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4604732 0.578 rs12040725 chr1:247644697 T/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.62 8.07 0.44 2.41e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2985684 0.895 rs3007033 chr14:50103816 T/C cg02151108 chr14:50098012 C14orf104 -0.42 -5.45 -0.32 1.17e-7 Carotid intima media thickness; CESC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg04369109 chr6:150039330 LATS1 -0.37 -5.08 -0.3 6.98e-7 Lung cancer; CESC cis rs11098499 0.863 rs1010740 chr4:120463409 C/T cg09307838 chr4:120376055 NA -0.89 -12.0 -0.59 8.4e-27 Corneal astigmatism; CESC cis rs847577 0.722 rs1013887 chr7:97709345 G/T cg21770322 chr7:97807741 LMTK2 0.63 10.36 0.54 2.53e-21 Breast cancer; CESC cis rs4604732 0.588 rs7549495 chr1:247627806 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.09 0.3 6.91e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs3105593 0.605 rs3131562 chr15:50772479 C/T cg05456662 chr15:50716270 USP8 0.44 5.94 0.34 8.97e-9 QT interval; CESC trans rs1275468 0.798 rs2366987 chr12:75930126 G/A cg01020758 chr17:39643308 KRT36 -0.44 -6.15 -0.35 2.79e-9 Polycystic ovary syndrome; CESC cis rs17001868 0.568 rs9607702 chr22:40739177 A/G cg07138101 chr22:40742427 ADSL 0.57 5.38 0.31 1.66e-7 Mammographic density (dense area); CESC cis rs1008375 0.932 rs4698629 chr4:17608884 C/G cg02297831 chr4:17616191 MED28 0.48 5.39 0.31 1.56e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7107174 0.901 rs866901 chr11:77926309 C/T cg02023728 chr11:77925099 USP35 0.47 5.97 0.34 7.71e-9 Testicular germ cell tumor; CESC cis rs8078723 1.000 rs59925331 chr17:38169273 C/G cg17467752 chr17:38218738 THRA 0.67 9.97 0.52 4.3e-20 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg14664628 chr15:75095509 CSK -0.53 -6.69 -0.38 1.29e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs35146811 0.520 rs1015538 chr7:99626035 A/G cg22906224 chr7:99728672 NA -0.48 -5.73 -0.33 2.7e-8 Coronary artery disease; CESC trans rs35110281 0.748 rs2838324 chr21:44999820 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 7.45 0.42 1.29e-12 Mean corpuscular volume; CESC cis rs6662572 0.737 rs7533750 chr1:46558434 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.17 0.3 4.73e-7 Blood protein levels; CESC cis rs9948 0.529 rs62152773 chr2:97448073 T/C cg01990225 chr2:97406019 LMAN2L -0.92 -7.51 -0.42 9.04e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs7336332 0.598 rs12018313 chr13:28012266 C/A cg01674679 chr13:27998804 GTF3A -0.58 -5.34 -0.31 2.04e-7 Weight; CESC cis rs12142240 0.660 rs72890715 chr1:46852077 A/G cg10495392 chr1:46806563 NSUN4 0.56 6.15 0.35 2.86e-9 Menopause (age at onset); CESC cis rs9443189 0.950 rs276698 chr6:76473071 T/C cg01950844 chr6:76311363 SENP6 0.63 6.19 0.36 2.26e-9 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06130365 chr10:135122020 TUBGCP2;ZNF511 -0.47 -6.33 -0.36 1.02e-9 Fibrinogen levels; CESC cis rs1950626 0.833 rs35151884 chr14:101394196 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.81 10.85 0.55 5.99e-23 Pelvic organ prolapse (moderate/severe); CESC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg11905131 chr22:24372483 LOC391322 -0.74 -10.64 -0.55 2.97e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1499972 0.941 rs2860308 chr3:117690309 T/G cg07612923 chr3:117604196 NA -0.86 -7.19 -0.4 6.63e-12 Schizophrenia; CESC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg22143856 chr6:28129313 ZNF389 0.42 5.24 0.31 3.23e-7 Parkinson's disease; CESC cis rs9811920 0.799 rs9832134 chr3:99836722 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 5.98 0.34 7.36e-9 Axial length; CESC cis rs2228479 0.850 rs11640209 chr16:89807828 C/A cg14709524 chr16:89940631 TCF25 0.92 6.97 0.39 2.55e-11 Skin colour saturation; CESC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC trans rs7937682 0.924 rs495460 chr11:111504777 G/A cg18187862 chr3:45730750 SACM1L 0.51 6.47 0.37 4.81e-10 Primary sclerosing cholangitis; CESC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.78 0.33 2.14e-8 Menopause (age at onset); CESC cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs72627123 0.656 rs117129791 chr14:74520871 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.36 0.31 1.81e-7 Morning vs. evening chronotype; CESC cis rs2637266 0.967 rs6480826 chr10:78356154 A/G cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs2228479 0.850 rs62056068 chr16:89909737 C/T cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg10691866 chr7:65817282 TPST1 -0.32 -5.27 -0.31 2.87e-7 Aortic root size; CESC cis rs4969178 0.965 rs2292642 chr17:76395430 C/T cg05887092 chr17:76393375 PGS1 0.58 9.14 0.49 1.64e-17 HDL cholesterol levels; CESC cis rs1355223 0.506 rs11032894 chr11:34865544 T/C cg11622362 chr11:34938112 PDHX;APIP 0.44 5.29 0.31 2.52e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg24562669 chr7:97807699 LMTK2 0.53 7.91 0.44 7e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs8103278 0.507 rs522769 chr19:46284520 G/A cg14061069 chr19:46274453 DMPK 0.51 8.02 0.44 3.46e-14 Coronary artery disease; CESC cis rs5769765 0.773 rs11090920 chr22:50320105 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.54 -5.05 -0.3 8.4e-7 Schizophrenia; CESC cis rs796364 0.806 rs1106400 chr2:201004089 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -6.43 -0.37 5.87e-10 Schizophrenia; CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg14893161 chr1:205819251 PM20D1 0.98 18.76 0.76 1.49e-50 Menarche (age at onset); CESC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg13628971 chr7:2884303 GNA12 0.62 8.04 0.44 2.94e-14 Height; CESC cis rs8017423 0.967 rs11621045 chr14:90714003 C/T cg14092571 chr14:90743983 NA -0.58 -8.72 -0.47 3.01e-16 Mortality in heart failure; CESC cis rs6430585 0.528 rs12474975 chr2:136702118 A/T cg07169764 chr2:136633963 MCM6 1.27 17.82 0.74 3.19e-47 Corneal structure; CESC cis rs7584330 0.518 rs74478860 chr2:238437364 C/G cg14458575 chr2:238380390 NA 0.72 6.85 0.39 5.03e-11 Prostate cancer; CESC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg00750074 chr16:89608354 SPG7 -0.43 -6.23 -0.36 1.78e-9 Multiple myeloma (IgH translocation); CESC cis rs1003719 0.688 rs2000416 chr21:38540089 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.7 -0.43 2.7e-13 Eye color traits; CESC cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.75 -12.21 -0.6 1.7e-27 Personality dimensions; CESC cis rs12681288 0.823 rs12681230 chr8:994422 G/A cg04851639 chr8:1020857 NA -0.35 -7.84 -0.43 1.09e-13 Schizophrenia; CESC cis rs9467711 0.606 rs35307327 chr6:26370474 C/T cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg11494091 chr17:61959527 GH2 0.74 13.02 0.62 2.62e-30 Prudent dietary pattern; CESC cis rs9399137 0.507 rs7745289 chr6:135380327 A/G cg22676075 chr6:135203613 NA 0.53 7.01 0.4 1.95e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17697381 chr3:148709363 GYG1 0.54 6.2 0.36 2.14e-9 Gut microbiome composition (summer); CESC cis rs12477438 0.765 rs9710648 chr2:99673129 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg11965913 chr1:205819406 PM20D1 0.46 6.26 0.36 1.53e-9 Menarche (age at onset); CESC cis rs7927771 1.000 rs4752873 chr11:47857520 C/T cg05585544 chr11:47624801 NA -0.49 -7.71 -0.43 2.62e-13 Subjective well-being; CESC cis rs6587515 0.748 rs4970970 chr1:150637953 A/C cg13175981 chr1:150552382 MCL1 0.62 5.67 0.33 3.75e-8 Pericardial adipose tissue adjusted for height and weight; CESC cis rs963731 0.579 rs6739568 chr2:39287550 G/T cg04010122 chr2:39346883 SOS1 -0.71 -5.67 -0.33 3.76e-8 Corticobasal degeneration; CESC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg11941060 chr3:133502564 NA -0.45 -6.02 -0.35 5.76e-9 Iron status biomarkers; CESC cis rs28386778 0.700 rs12449555 chr17:62003982 T/A cg26338869 chr17:61819248 STRADA -0.65 -8.1 -0.45 2.04e-14 Prudent dietary pattern; CESC cis rs7605827 0.930 rs10189180 chr2:15685949 T/C cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs4835473 0.932 rs1877235 chr4:144908114 A/G cg25736465 chr4:144833511 NA -0.39 -5.95 -0.34 8.51e-9 Immature fraction of reticulocytes; CESC cis rs7481584 1.000 rs12789474 chr11:3024139 T/G cg25174290 chr11:3078921 CARS -0.43 -5.43 -0.32 1.27e-7 Calcium levels; CESC cis rs7107174 0.892 rs11237477 chr11:78095069 A/T cg02023728 chr11:77925099 USP35 0.38 5.19 0.3 4.18e-7 Testicular germ cell tumor; CESC cis rs8072100 0.713 rs4968318 chr17:45451894 G/A cg25173405 chr17:45401733 C17orf57 -0.42 -5.27 -0.31 2.8e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs12079745 0.793 rs12089602 chr1:169180898 T/A cg09363564 chr1:169337483 NME7;BLZF1 -1.0 -6.14 -0.35 3e-9 QT interval; CESC cis rs10242455 0.702 rs73403286 chr7:99154865 A/C cg18809830 chr7:99032528 PTCD1 -0.66 -5.21 -0.3 3.84e-7 Blood metabolite levels; CESC cis rs2839186 0.706 rs2839188 chr21:47692798 C/T cg12379764 chr21:47803548 PCNT -0.51 -6.53 -0.37 3.42e-10 Testicular germ cell tumor; CESC cis rs3820928 0.874 rs1054413 chr2:227867719 A/G cg11843606 chr2:227700838 RHBDD1 0.44 5.61 0.33 5.01e-8 Pulmonary function; CESC cis rs3768617 0.510 rs2296291 chr1:183079509 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 14.14 0.66 3.44e-34 Fuchs's corneal dystrophy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01399255 chr7:100271274 GNB2 -0.45 -6.38 -0.36 7.73e-10 Fibrinogen levels; CESC trans rs1814175 0.817 rs2866545 chr11:49630824 A/C cg15704280 chr7:45808275 SEPT13 -1.01 -19.13 -0.76 7.6900000000000007e-52 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01190323 chr16:2498952 CCNF 0.49 6.77 0.38 8.07e-11 Fibrinogen levels; CESC cis rs12477438 0.520 rs6756650 chr2:99801800 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 15.36 0.69 1.63e-38 Chronic sinus infection; CESC cis rs662064 0.748 rs2026792 chr1:10594790 A/G cg20482658 chr1:10539492 PEX14 0.41 8.38 0.46 3.21e-15 Asthma; CESC cis rs2070997 0.607 rs7037741 chr9:133675110 C/A cg11464064 chr9:133710261 ABL1 0.62 7.24 0.41 4.73e-12 Response to amphetamines; CESC cis rs9633740 0.578 rs11185951 chr10:82301536 G/C cg00277334 chr10:82204260 NA 0.57 5.03 0.3 9.18e-7 Post bronchodilator FEV1; CESC cis rs4689388 0.926 rs4343789 chr4:6285228 C/G cg25554036 chr4:6271136 WFS1 0.57 9.52 0.5 1.15e-18 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6500395 1.000 rs9937610 chr16:48671274 C/G cg04672837 chr16:48644449 N4BP1 0.5 6.27 0.36 1.45e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2070488 0.662 rs7375040 chr3:38469116 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 8.73 0.47 2.85e-16 Electrocardiographic conduction measures; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22839093 chr8:144668199 EEF1D -0.43 -6.3 -0.36 1.22e-9 Gut microbiota (bacterial taxa); CESC cis rs7927771 1.000 rs4752856 chr11:47648042 C/T cg18512352 chr11:47633146 NA -0.63 -9.93 -0.52 5.79e-20 Subjective well-being; CESC cis rs910316 0.503 rs4903273 chr14:75441795 G/A cg08847533 chr14:75593920 NEK9 -0.7 -10.31 -0.53 3.67e-21 Height; CESC cis rs1568889 0.838 rs6484347 chr11:28040969 G/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.77 -12.7 -0.62 3.39e-29 Bipolar disorder; CESC cis rs854765 0.547 rs6502632 chr17:17913057 A/G cg04398451 chr17:18023971 MYO15A -0.66 -9.54 -0.51 9.59e-19 Total body bone mineral density; CESC cis rs10744422 0.920 rs3896871 chr12:123333610 G/T cg25930673 chr12:123319894 HIP1R -0.73 -5.73 -0.33 2.68e-8 Schizophrenia; CESC cis rs7385804 0.761 rs1734910 chr7:100309544 A/G cg20848291 chr7:100343083 ZAN 0.48 6.46 0.37 5.08e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs4664304 0.903 rs72957578 chr2:160754133 G/C cg03641300 chr2:160917029 PLA2R1 -0.48 -6.85 -0.39 5.03e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs9309473 0.519 rs35421685 chr2:73910138 T/C cg20560298 chr2:73613845 ALMS1 0.49 6.94 0.39 3.06e-11 Metabolite levels; CESC cis rs62064224 0.703 rs62065493 chr17:30822620 C/G cg25809561 chr17:30822961 MYO1D 0.63 9.17 0.49 1.41e-17 Schizophrenia; CESC cis rs4803455 0.586 rs4803457 chr19:41861359 T/C cg08477640 chr19:41863820 B9D2 0.49 6.87 0.39 4.65e-11 Migraine;Coronary artery disease; CESC cis rs9916302 0.904 rs57399933 chr17:37551189 A/G cg07936489 chr17:37558343 FBXL20 0.8 11.5 0.58 4.2e-25 Glomerular filtration rate (creatinine); CESC cis rs7914558 0.966 rs10786724 chr10:104668942 A/G cg15744005 chr10:104629667 AS3MT -0.34 -5.46 -0.32 1.09e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7178909 0.872 rs7179633 chr15:90434877 T/C cg19708238 chr15:90437601 AP3S2 0.43 6.13 0.35 3.11e-9 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03253314 chr19:17445711 ANO8 0.57 6.59 0.38 2.31e-10 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg12463550 chr7:65579703 CRCP -0.47 -6.08 -0.35 4.28e-9 Aortic root size; CESC cis rs870825 0.616 rs10428373 chr4:185639002 A/T cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17508018 chr19:40854374 C19orf47;PLD3 -0.69 -8.33 -0.46 4.45e-15 Gut microbiome composition (summer); CESC cis rs9486719 1.000 rs12208124 chr6:97027942 C/T cg18709589 chr6:96969512 KIAA0776 -0.49 -5.3 -0.31 2.46e-7 Migraine;Coronary artery disease; CESC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.17 0.3 4.63e-7 Menopause (age at onset); CESC cis rs2243480 1.000 rs387676 chr7:65598220 C/T cg18252515 chr7:66147081 NA -1.41 -14.36 -0.66 5.44e-35 Diabetic kidney disease; CESC cis rs9913156 0.793 rs55974786 chr17:4567564 T/C cg00122941 chr17:4613640 ARRB2 0.86 10.13 0.53 1.34e-20 Lymphocyte counts; CESC cis rs1865721 0.771 rs7236311 chr18:73137450 A/G cg26385618 chr18:73139727 C18orf62 -0.53 -8.81 -0.48 1.69e-16 Intelligence; CESC cis rs12142240 0.698 rs1475388 chr1:46816465 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg12590608 chr7:158785262 NA 0.32 5.46 0.32 1.07e-7 Facial morphology (factor 20); CESC cis rs13242816 1.000 rs2188243 chr7:116109293 G/A cg04696780 chr7:116139425 CAV2 -0.63 -5.71 -0.33 2.98e-8 P wave duration; CESC cis rs7274811 0.744 rs6141411 chr20:32157934 G/A cg21523528 chr20:32077966 CBFA2T2 0.45 5.43 0.32 1.25e-7 Height; CESC cis rs6570726 0.791 rs6902404 chr6:145905254 G/A cg05347473 chr6:146136440 FBXO30 0.48 6.32 0.36 1.08e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.09 -0.35 3.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6484504 0.576 rs11031320 chr11:31242545 C/T cg14844989 chr11:31128820 NA -0.43 -5.99 -0.35 6.7e-9 Red blood cell count; CESC cis rs4450798 0.793 rs28541501 chr3:13757636 G/T cg23332027 chr3:13681764 NA 0.38 5.26 0.31 2.99e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs733175 0.857 rs751092 chr4:10005897 C/T cg00071950 chr4:10020882 SLC2A9 0.51 5.79 0.33 2.03e-8 Psychosis and Alzheimer's disease; CESC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.83 -11.88 -0.59 2.17e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2180341 1.000 rs9321073 chr6:127609691 C/T cg24812749 chr6:127587940 RNF146 1.06 15.35 0.69 1.74e-38 Breast cancer; CESC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.91 13.93 0.65 1.85e-33 Prudent dietary pattern; CESC cis rs7520050 0.933 rs6694340 chr1:46289416 C/T cg24296786 chr1:45957014 TESK2 0.42 5.42 0.32 1.33e-7 Red blood cell count;Reticulocyte count; CESC cis rs1451375 0.652 rs7779110 chr7:50625651 T/C cg14593290 chr7:50529359 DDC 0.44 5.37 0.31 1.71e-7 Malaria; CESC cis rs67311347 1.000 rs7631893 chr3:40440869 C/T cg24209194 chr3:40518798 ZNF619 0.5 6.9 0.39 3.84e-11 Renal cell carcinoma; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg22741997 chr17:6900356 ALOX12 0.43 6.84 0.39 5.59e-11 Tonsillectomy; CESC cis rs476633 0.691 rs2164996 chr15:41536624 A/G cg20272979 chr15:41787780 ITPKA 0.34 5.12 0.3 5.94e-7 Glomerular filtration rate (creatinine); CESC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg12463550 chr7:65579703 CRCP 0.55 6.9 0.39 3.78e-11 Aortic root size; CESC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg23172400 chr8:95962367 TP53INP1 -0.44 -9.04 -0.49 3.45e-17 Type 2 diabetes; CESC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -7.65 -0.43 3.81e-13 Personality dimensions; CESC cis rs2576037 0.583 rs680018 chr18:44409167 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.98 0.62 3.75e-30 Personality dimensions; CESC cis rs1215050 0.740 rs9994227 chr4:98767094 T/G cg05340658 chr4:99064831 C4orf37 0.53 6.85 0.39 5.29e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 10.95 0.56 2.82e-23 Platelet count; CESC trans rs8073060 0.586 rs2428464 chr17:34021994 C/G cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs3733585 0.638 rs6449155 chr4:9956547 T/G cg00071950 chr4:10020882 SLC2A9 -0.7 -11.52 -0.58 3.7e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs10851478 0.500 rs36023246 chr15:49699311 A/G cg08060515 chr15:49448048 GALK2;COPS2 0.52 6.63 0.38 1.87e-10 Oral cavity cancer; CESC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg01238044 chr22:24384105 GSTT1 0.52 6.63 0.38 1.93e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs61931739 0.782 rs1197569 chr12:34186733 A/T cg26384229 chr12:38710491 ALG10B 0.48 6.59 0.38 2.39e-10 Morning vs. evening chronotype; CESC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 7.2 0.4 6.18e-12 Depression; CESC cis rs10504229 1.000 rs57378064 chr8:58169844 C/G cg22535103 chr8:58192502 C8orf71 -0.87 -11.04 -0.56 1.45e-23 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.07 -0.35 4.3e-9 Depression; CESC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg18758796 chr5:131593413 PDLIM4 0.41 5.54 0.32 7.27e-8 Acylcarnitine levels; CESC cis rs2180341 1.000 rs9398838 chr6:127635285 C/T cg27446573 chr6:127587934 RNF146 1.09 16.38 0.71 3.79e-42 Breast cancer; CESC cis rs7917772 0.503 rs1409310 chr10:104282265 T/C cg22532475 chr10:104410764 TRIM8 -0.33 -5.67 -0.33 3.77e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2276314 0.857 rs8087539 chr18:33631537 C/T cg05985134 chr18:33552581 C18orf21 0.63 7.59 0.42 5.58e-13 Endometriosis;Drug-induced torsades de pointes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19026356 chr22:50624276 TRABD 0.62 7.22 0.41 5.38e-12 Gut microbiome composition (summer); CESC trans rs12599106 0.715 rs34006830 chr16:34878550 C/A cg01171360 chr6:293285 DUSP22 -0.66 -8.29 -0.45 5.83e-15 Menopause (age at onset); CESC cis rs2180341 1.000 rs3798850 chr6:127613966 C/T cg24812749 chr6:127587940 RNF146 1.06 15.35 0.69 1.74e-38 Breast cancer; CESC cis rs4728302 0.869 rs6978170 chr7:133603838 C/T cg10665199 chr7:133106180 EXOC4 0.4 5.56 0.32 6.62e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs10791097 0.694 rs4459316 chr11:130756176 T/C cg12179176 chr11:130786555 SNX19 0.65 10.22 0.53 6.73e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2929278 0.588 rs688009 chr15:44156302 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.5 6.52 0.37 3.44e-10 Schizophrenia; CESC cis rs6460942 0.556 rs10228123 chr7:12374025 A/C cg06484146 chr7:12443880 VWDE -0.51 -7.17 -0.4 7.48e-12 Coronary artery disease; CESC cis rs2933343 0.951 rs789217 chr3:128593201 C/T cg25356066 chr3:128598488 ACAD9 0.55 6.9 0.39 3.73e-11 IgG glycosylation; CESC cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg20891283 chr12:69753455 YEATS4 0.97 16.63 0.71 4.93e-43 Cerebrospinal fluid biomarker levels; CESC trans rs9388451 0.559 rs1777210 chr6:126098916 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.57 -7.45 -0.42 1.28e-12 Brugada syndrome; CESC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.44 6.59 0.38 2.31e-10 Total body bone mineral density; CESC cis rs7178572 0.568 rs11072643 chr15:77415508 T/A cg22256960 chr15:77711686 NA 0.52 6.32 0.36 1.1e-9 Type 2 diabetes; CESC trans rs561341 0.609 rs4795659 chr17:30187139 C/G cg20587970 chr11:113659929 NA 0.57 6.96 0.39 2.65e-11 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04958845 chr8:101170202 SPAG1 0.69 7.87 0.44 9.06e-14 Gut microbiome composition (summer); CESC cis rs4523957 0.928 rs216176 chr17:2168509 G/C cg16513277 chr17:2031491 SMG6 0.6 8.09 0.45 2.16e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7662987 0.517 rs2602878 chr4:100039953 T/G cg13256891 chr4:100009986 ADH5 0.75 8.06 0.44 2.6e-14 Smoking initiation; CESC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg01448562 chr3:133502909 NA 0.58 8.44 0.46 2.06e-15 Iron status biomarkers; CESC cis rs6598955 0.724 rs12132137 chr1:26631243 C/T cg19743891 chr1:26644573 UBXN11;CD52 -0.27 -5.21 -0.3 3.84e-7 Obesity-related traits; CESC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg00149659 chr3:10157352 C3orf10 0.73 8.73 0.47 2.9e-16 Alzheimer's disease; CESC trans rs877282 0.520 rs12360072 chr10:813082 C/T cg22713356 chr15:30763199 NA 0.63 7.37 0.41 2.15e-12 Uric acid levels; CESC cis rs9457247 0.612 rs2237273 chr6:167443017 T/C cg07741184 chr6:167504864 NA 0.33 5.78 0.33 2.04e-8 Crohn's disease; CESC cis rs854765 0.547 rs2955380 chr17:17944349 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.81 -0.48 1.7e-16 Total body bone mineral density; CESC cis rs963731 0.571 rs4670270 chr2:39230351 G/A cg04010122 chr2:39346883 SOS1 -0.69 -5.14 -0.3 5.41e-7 Corticobasal degeneration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02396668 chr19:50528878 VRK3;ZNF473 -0.47 -6.86 -0.39 4.98e-11 Gambling; CESC cis rs6964587 1.000 rs12530646 chr7:91588036 A/G cg17063962 chr7:91808500 NA -0.56 -7.77 -0.43 1.72e-13 Breast cancer; CESC cis rs611744 0.563 rs7815105 chr8:109298794 C/T cg21045802 chr8:109455806 TTC35 0.52 6.19 0.36 2.33e-9 Dupuytren's disease; CESC cis rs9309473 1.000 rs13428235 chr2:73633430 G/A cg20560298 chr2:73613845 ALMS1 -0.51 -6.72 -0.38 1.13e-10 Metabolite levels; CESC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg19163074 chr7:65112434 INTS4L2 0.52 5.35 0.31 1.87e-7 Aortic root size; CESC cis rs17401966 0.898 rs1396 chr1:10247143 C/A cg15208524 chr1:10270712 KIF1B 0.51 6.43 0.37 5.92e-10 Hepatocellular carcinoma; CESC cis rs1670533 0.872 rs11727136 chr4:1051804 G/A cg27284194 chr4:1044797 NA 0.42 5.17 0.3 4.53e-7 Recombination rate (females); CESC trans rs17685 0.753 rs1637039 chr7:75693009 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 12.37 0.61 4.74e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs6088590 0.687 rs8115656 chr20:33282780 G/C cg08999081 chr20:33150536 PIGU 0.66 10.88 0.56 5.07e-23 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14929913 chr10:1147979 WDR37 0.52 7.05 0.4 1.6e-11 Fibrinogen levels; CESC cis rs6456156 0.586 rs2345753 chr6:167484344 T/A cg07741184 chr6:167504864 NA 0.37 6.36 0.36 8.83e-10 Primary biliary cholangitis; CESC cis rs344364 0.636 rs344363 chr16:1972548 C/T cg03013636 chr16:1946785 NA 0.4 5.06 0.3 7.98e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs7267979 0.586 rs11087505 chr20:25196520 T/A cg24626310 chr20:25276739 ABHD12;PYGB 0.71 11.99 0.59 9.41e-27 Liver enzyme levels (alkaline phosphatase); CESC cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.3 0.31 2.41e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9486719 1.000 rs2145535 chr6:97034715 G/A cg18709589 chr6:96969512 KIAA0776 -0.5 -5.44 -0.32 1.21e-7 Migraine;Coronary artery disease; CESC cis rs5769707 0.609 rs135861 chr22:49998118 A/G cg05373962 chr22:49881684 NA -0.35 -5.21 -0.3 3.75e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs17666538 0.710 rs12716640 chr8:645376 A/C cg26554054 chr8:600488 NA 0.61 5.36 0.31 1.81e-7 IgG glycosylation; CESC cis rs2439831 0.850 rs2277531 chr15:44069069 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.7 6.79 0.38 7.39e-11 Lung cancer in ever smokers; CESC cis rs9815354 1.000 rs9857175 chr3:41822054 T/G cg03022575 chr3:42003672 ULK4 0.47 5.16 0.3 4.95e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7714584 1.000 rs61270113 chr5:150226263 G/A cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg06808227 chr14:105710500 BRF1 0.6 7.35 0.41 2.43e-12 Mean platelet volume;Platelet distribution width; CESC cis rs62229266 0.557 rs4817761 chr21:37395556 C/T cg12218747 chr21:37451666 NA -0.43 -5.91 -0.34 1.06e-8 Mitral valve prolapse; CESC cis rs7851660 0.809 rs10818241 chr9:100661972 A/G cg13688889 chr9:100608707 NA -0.62 -8.87 -0.48 1.11e-16 Strep throat; CESC cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.7 -7.93 -0.44 6.33e-14 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17575087 chr5:154237720 CNOT8 -0.49 -6.48 -0.37 4.52e-10 Fibrinogen levels; CESC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg17221315 chr6:27791827 HIST1H4J 0.43 5.47 0.32 1.03e-7 Cardiac Troponin-T levels; CESC trans rs66573146 0.656 rs57454756 chr4:6958582 C/T cg07817883 chr1:32538562 TMEM39B 1.43 8.7 0.47 3.61e-16 Granulocyte percentage of myeloid white cells; CESC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 5.76 0.33 2.35e-8 Bipolar disorder; CESC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.21 0.53 7.62e-21 Prudent dietary pattern; CESC cis rs6456156 0.586 rs9457261 chr6:167467679 A/G cg07741184 chr6:167504864 NA 0.36 6.17 0.35 2.48e-9 Primary biliary cholangitis; CESC cis rs860295 0.580 rs6672284 chr1:155277963 C/T cg02153340 chr1:155202674 NA -0.36 -5.07 -0.3 7.47e-7 Body mass index; CESC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg18230493 chr5:56204884 C5orf35 -0.72 -8.27 -0.45 6.38e-15 Initial pursuit acceleration; CESC cis rs3859192 0.599 rs34342173 chr17:38161507 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.61 9.08 0.49 2.59e-17 White blood cell count; CESC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg22143856 chr6:28129313 ZNF389 0.45 5.97 0.34 7.71e-9 Depression; CESC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg24250549 chr1:154909240 PMVK 0.62 8.99 0.48 4.74e-17 Prostate cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17622922 chr11:119187849 MCAM -0.47 -6.27 -0.36 1.44e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg23161317 chr6:28129485 ZNF389 0.51 6.38 0.36 7.9e-10 Parkinson's disease; CESC cis rs4629180 0.586 rs2048252 chr2:102138384 C/T cg04415270 chr2:102091202 RFX8 -0.31 -5.35 -0.31 1.86e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg02375832 chr11:62437615 C11orf48 -0.39 -5.45 -0.32 1.15e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7833790 1.000 rs28696138 chr8:82770794 G/A cg27398817 chr8:82754497 SNX16 0.56 6.44 0.37 5.68e-10 Diastolic blood pressure; CESC cis rs2735413 0.881 rs12923218 chr16:78080274 C/G cg04733911 chr16:78082701 NA -0.54 -9.15 -0.49 1.54e-17 Systolic blood pressure (alcohol consumption interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16181848 chr18:2913135 EMILIN2 -0.62 -7.21 -0.4 5.79e-12 Gut microbiome composition (summer); CESC cis rs8005677 0.962 rs11157931 chr14:23403193 A/C cg25600027 chr14:23388339 RBM23 -0.43 -5.23 -0.31 3.43e-7 Cognitive ability (multi-trait analysis); CESC cis rs1448094 0.872 rs4919777 chr12:86358491 C/T cg02569458 chr12:86230093 RASSF9 0.36 5.44 0.32 1.19e-7 Major depressive disorder; CESC cis rs898097 0.528 rs2243523 chr17:80680449 G/T cg20271620 chr17:80763330 TBCD 0.42 5.51 0.32 8.65e-8 Breast cancer; CESC cis rs208520 0.690 rs207091 chr6:66799847 G/T cg07460842 chr6:66804631 NA -1.0 -13.43 -0.64 1.05e-31 Exhaled nitric oxide output; CESC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg24399712 chr22:39784796 NA -0.88 -10.98 -0.56 2.3e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs68170813 0.559 rs7794598 chr7:106826381 C/T cg02696742 chr7:106810147 HBP1 -0.57 -5.63 -0.33 4.54e-8 Coronary artery disease; CESC cis rs2732480 0.577 rs2634680 chr12:48734564 T/C cg24011408 chr12:48396354 COL2A1 0.44 5.94 0.34 9.12e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9925964 0.804 rs4889606 chr16:31011183 C/T cg02466173 chr16:30829666 NA -0.36 -5.47 -0.32 1.05e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6032067 0.777 rs34073275 chr20:43788917 C/T cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs73001065 0.591 rs2285626 chr19:19467545 C/T cg03709012 chr19:19516395 GATAD2A 1.03 8.92 0.48 7.63e-17 LDL cholesterol; CESC trans rs561341 0.602 rs114562703 chr17:30233899 G/T cg20587970 chr11:113659929 NA -0.64 -8.12 -0.45 1.74e-14 Hip circumference adjusted for BMI; CESC cis rs453301 0.686 rs17702602 chr8:8908596 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -5.33 -0.31 2.14e-7 Joint mobility (Beighton score); CESC cis rs1538970 0.884 rs781226 chr1:45872662 T/C cg24296786 chr1:45957014 TESK2 0.44 5.41 0.32 1.41e-7 Platelet count; CESC cis rs2456568 0.867 rs4753111 chr11:93658410 A/G cg26875233 chr11:93583750 C11orf90 -0.32 -5.56 -0.32 6.54e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs7100689 0.646 rs11202725 chr10:82136276 A/G cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg07701084 chr6:150067640 NUP43 0.46 6.45 0.37 5.22e-10 Lung cancer; CESC cis rs10924309 0.882 rs10924306 chr1:245857065 G/A cg00036263 chr1:245852353 KIF26B -0.42 -5.09 -0.3 6.65e-7 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg15445000 chr17:37608096 MED1 -0.4 -6.46 -0.37 4.97e-10 Glomerular filtration rate (creatinine); CESC cis rs3767633 0.925 rs10733044 chr1:161903534 A/G cg09175582 chr1:161736000 ATF6 -0.84 -7.12 -0.4 1.01e-11 IgG glycosylation; CESC cis rs858239 0.632 rs6952947 chr7:23121042 C/G cg23682824 chr7:23144976 KLHL7 -0.55 -7.75 -0.43 1.96e-13 Cerebrospinal fluid biomarker levels; CESC cis rs7089973 0.604 rs11196937 chr10:116589500 G/C cg23260525 chr10:116636907 FAM160B1 0.4 7.19 0.4 6.76e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9488822 0.596 rs13206506 chr6:116324460 A/G cg26893134 chr6:116381904 FRK 0.22 5.13 0.3 5.7e-7 Cholesterol, total;LDL cholesterol; CESC cis rs561341 0.739 rs8070554 chr17:30216868 A/T cg13647721 chr17:30228624 UTP6 -0.76 -9.22 -0.49 9.53e-18 Hip circumference adjusted for BMI; CESC cis rs1062177 0.756 rs2964588 chr5:151118386 C/T cg00977110 chr5:151150581 G3BP1 -0.62 -6.36 -0.36 8.61e-10 Preschool internalizing problems; CESC cis rs7824557 0.602 rs11784544 chr8:11204503 G/C cg21775007 chr8:11205619 TDH 0.58 8.98 0.48 5.08e-17 Retinal vascular caliber; CESC cis rs60871478 0.898 rs4725241 chr7:796883 C/T cg05535760 chr7:792225 HEATR2 0.85 10.45 0.54 1.26e-21 Cerebrospinal P-tau181p levels; CESC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.28 -0.36 1.4e-9 Developmental language disorder (linguistic errors); CESC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg23161317 chr6:28129485 ZNF389 0.5 6.24 0.36 1.69e-9 Depression; CESC cis rs4654899 0.743 rs17409373 chr1:21188871 C/A cg05370193 chr1:21551575 ECE1 0.39 5.65 0.33 4.12e-8 Superior frontal gyrus grey matter volume; CESC cis rs6088590 0.965 rs6058108 chr20:33288655 A/G cg08999081 chr20:33150536 PIGU 0.59 9.22 0.49 9.93e-18 Coronary artery disease; CESC cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg12923728 chr3:195709715 SDHAP1 -0.68 -9.13 -0.49 1.76e-17 Pancreatic cancer; CESC cis rs1050631 0.592 rs1789527 chr18:33712229 C/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.52 7.14 0.4 9.15e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs2898681 0.561 rs58577680 chr4:53734294 C/T cg00791764 chr4:53727839 RASL11B 0.44 5.16 0.3 4.81e-7 Optic nerve measurement (cup area); CESC cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg25554036 chr4:6271136 WFS1 0.52 8.45 0.46 1.93e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs10791097 0.694 rs876641 chr11:130752040 A/C cg12179176 chr11:130786555 SNX19 0.66 10.4 0.54 1.79e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs834811 0.829 rs6980107 chr7:135900757 C/T cg01726295 chr7:135938950 NA -0.37 -6.24 -0.36 1.73e-9 Post-traumatic stress disorder; CESC cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg18180107 chr4:99064573 C4orf37 0.42 5.41 0.32 1.44e-7 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07898632 chr15:73345666 NEO1 -0.5 -6.03 -0.35 5.58e-9 Ulcerative colitis; CESC cis rs7216064 0.532 rs3890640 chr17:66053028 C/T cg12091567 chr17:66097778 LOC651250 0.92 12.28 0.6 9.74e-28 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7267979 1.000 rs6083825 chr20:25366424 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.23e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs116095464 0.558 rs10076655 chr5:239464 G/C cg22857025 chr5:266934 NA -1.29 -18.85 -0.76 7.31e-51 Breast cancer; CESC cis rs9324022 0.858 rs1004572 chr14:101178330 G/A cg18089426 chr14:101175970 NA 0.59 7.51 0.42 9.29e-13 Plateletcrit; CESC cis rs3733585 0.637 rs6850684 chr4:9964380 G/T cg02734326 chr4:10020555 SLC2A9 -0.44 -6.15 -0.35 2.85e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2880765 0.835 rs4843063 chr15:86048748 G/T cg19183879 chr15:85880815 NA -0.26 -5.29 -0.31 2.52e-7 Coronary artery disease; CESC cis rs1371867 0.846 rs1692007 chr8:101268343 T/C cg11906718 chr8:101322791 RNF19A -0.42 -5.47 -0.32 1.06e-7 Atrioventricular conduction; CESC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg06108461 chr20:60628389 TAF4 -0.92 -14.55 -0.67 1.22e-35 Body mass index; CESC cis rs8044868 0.530 rs12932845 chr16:72122765 G/A cg16558253 chr16:72132732 DHX38 -0.4 -6.23 -0.36 1.79e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs2549003 0.966 rs839 chr5:131819126 C/T cg00255919 chr5:131827918 IRF1 0.51 8.59 0.47 7.76e-16 Asthma (sex interaction); CESC cis rs17376456 0.542 rs10070350 chr5:93103753 C/G cg25358565 chr5:93447407 FAM172A 0.68 7.25 0.41 4.53e-12 Diabetic retinopathy; CESC cis rs6964587 1.000 rs12536529 chr7:91684086 C/T cg17063962 chr7:91808500 NA -0.57 -7.93 -0.44 6.23e-14 Breast cancer; CESC cis rs7219021 0.961 rs9901447 chr17:46872346 C/T cg16584676 chr17:46985605 UBE2Z -0.72 -8.09 -0.44 2.23e-14 Schizophrenia or bipolar disorder; CESC cis rs2302729 0.578 rs10774052 chr12:2772171 C/T cg19945202 chr12:2788847 CACNA1C -0.49 -7.28 -0.41 3.89e-12 Sleep quality; CESC cis rs4561483 0.624 rs2215928 chr16:11927918 A/T cg08843971 chr16:11963173 GSPT1 -0.44 -6.16 -0.35 2.72e-9 Testicular germ cell tumor; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07464025 chr10:13482639 BEND7 -0.46 -6.13 -0.35 3.11e-9 Fibrinogen levels; CESC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg04944784 chr2:26401820 FAM59B -0.7 -8.24 -0.45 8.15e-15 Gut microbiome composition (summer); CESC cis rs61996546 0.622 rs34661562 chr15:26849631 A/G cg15066197 chr15:26874202 GABRB3 -0.35 -5.19 -0.3 4.1e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10039444 chr14:56233676 RPL13AP3 0.47 7.17 0.4 7.29e-12 Ulcerative colitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05889321 chr10:97416837 ALDH18A1 -0.44 -6.32 -0.36 1.12e-9 Gambling; CESC cis rs10504229 0.679 rs16921683 chr8:58053270 T/C cg24829409 chr8:58192753 C8orf71 -0.5 -6.27 -0.36 1.43e-9 Developmental language disorder (linguistic errors); CESC cis rs637571 0.546 rs10791827 chr11:65596546 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.66 -8.39 -0.46 2.86e-15 Eosinophil percentage of white cells; CESC cis rs1153858 1.000 rs11070457 chr15:45686943 A/C cg21132104 chr15:45694354 SPATA5L1 0.86 11.67 0.58 1.14e-25 Homoarginine levels; CESC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg22467129 chr15:76604101 ETFA -0.37 -5.66 -0.33 3.94e-8 Blood metabolite levels; CESC cis rs11122272 0.735 rs2790897 chr1:231491712 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.48 -0.42 1.1e-12 Hemoglobin concentration; CESC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg11663144 chr21:46675770 NA -0.63 -9.94 -0.52 5.62e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs941764 0.965 rs941765 chr14:91841358 G/C cg10511902 chr14:91842949 CCDC88C 0.54 8.3 0.45 5.2e-15 Breast cancer; CESC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg17971929 chr21:40555470 PSMG1 1.08 16.46 0.71 2e-42 Cognitive function; CESC cis rs9796 0.689 rs692195 chr15:41444894 G/C cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.36 -0.36 8.97e-10 Menopause (age at onset); CESC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.91 10.67 0.55 2.33e-22 Platelet count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23819836 chr6:15663134 DTNBP1 -0.48 -6.44 -0.37 5.45e-10 Ulcerative colitis; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.8 -0.39 6.98e-11 Electroencephalogram traits; CESC cis rs854765 0.583 rs950966 chr17:17783748 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.47 -6.05 -0.35 5.01e-9 Total body bone mineral density; CESC cis rs11122272 0.701 rs1009227 chr1:231480507 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.23 -0.41 5.18e-12 Hemoglobin concentration; CESC cis rs75804782 0.641 rs3769123 chr2:239349328 C/G cg18131467 chr2:239335373 ASB1 -0.66 -5.83 -0.34 1.58e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs910316 0.763 rs175014 chr14:75456927 A/G cg08847533 chr14:75593920 NEK9 -0.86 -14.07 -0.65 6.01e-34 Height; CESC cis rs12586317 0.547 rs10145723 chr14:35460954 G/A cg05294307 chr14:35346193 BAZ1A -0.51 -5.48 -0.32 1e-7 Psoriasis; CESC cis rs6582630 0.555 rs7294313 chr12:38323603 G/A cg26384229 chr12:38710491 ALG10B -0.42 -5.42 -0.32 1.32e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs3020736 0.500 rs1801311 chr22:42486723 G/A cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC cis rs1055129 0.682 rs7217432 chr17:73834604 A/G cg08125733 chr17:73851984 WBP2 0.52 7.21 0.41 5.8e-12 White matter hyperintensity burden; CESC cis rs6963495 0.818 rs73192143 chr7:105202415 A/G cg13798780 chr7:105162888 PUS7 0.77 7.64 0.42 4.08e-13 Bipolar disorder (body mass index interaction); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg05335107 chr2:109400084 RANBP2 0.38 6.14 0.35 2.95e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4253772 0.515 rs7287164 chr22:46781008 T/C cg00784671 chr22:46762841 CELSR1 -0.66 -6.13 -0.35 3.13e-9 LDL cholesterol;Cholesterol, total; CESC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg24733560 chr20:60626293 TAF4 0.43 6.24 0.36 1.76e-9 Body mass index; CESC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg01448562 chr3:133502909 NA 0.44 6.0 0.35 6.37e-9 Iron status biomarkers; CESC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg05863683 chr7:1912471 MAD1L1 0.43 6.38 0.36 8.03e-10 Bipolar disorder and schizophrenia; CESC cis rs11608355 0.515 rs2270361 chr12:109935894 G/C cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs6484504 0.532 rs2761589 chr11:31311429 C/G cg14844989 chr11:31128820 NA 0.38 5.34 0.31 2.02e-7 Red blood cell count; CESC cis rs1348850 0.567 rs1527401 chr2:178522104 C/T cg23306229 chr2:178417860 TTC30B 0.54 7.13 0.4 9.28e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7666738 0.830 rs34916200 chr4:98851593 C/T cg17366294 chr4:99064904 C4orf37 0.55 7.72 0.43 2.38e-13 Colonoscopy-negative controls vs population controls; CESC cis rs9486715 0.867 rs9373887 chr6:96957004 C/T cg18709589 chr6:96969512 KIAA0776 0.46 6.52 0.37 3.49e-10 Headache; CESC cis rs76917914 0.820 rs4743158 chr9:100821275 T/C cg03040243 chr9:100819229 NANS 0.5 5.6 0.33 5.33e-8 Immature fraction of reticulocytes; CESC cis rs4481887 0.893 rs10788774 chr1:248471712 T/C cg00666640 chr1:248458726 OR2T12 0.39 6.38 0.37 7.75e-10 Common traits (Other); CESC cis rs57221529 0.825 rs72703051 chr5:582997 G/A cg16447950 chr5:562315 NA -0.63 -5.84 -0.34 1.5e-8 Lung disease severity in cystic fibrosis; CESC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg12463550 chr7:65579703 CRCP -0.49 -6.42 -0.37 6.41e-10 Aortic root size; CESC cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg16339924 chr4:17578868 LAP3 0.6 7.51 0.42 8.84e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7605827 0.930 rs7574879 chr2:15698083 C/G cg19274914 chr2:15703543 NA 0.37 6.58 0.37 2.43e-10 Educational attainment (years of education); CESC cis rs17384381 1.000 rs12140457 chr1:85860170 G/A cg16011679 chr1:85725395 C1orf52 0.8 8.15 0.45 1.47e-14 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04528624 chr13:60738126 DIAPH3 0.62 6.82 0.39 6.24e-11 Gut microbiome composition (summer); CESC cis rs2439831 0.850 rs2957637 chr15:43951118 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.98 0.44 4.41e-14 Lung cancer in ever smokers; CESC cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg02297831 chr4:17616191 MED28 -0.5 -5.74 -0.33 2.59e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs113835537 0.877 rs3867132 chr11:66309269 C/T cg22134325 chr11:66188745 NPAS4 0.52 5.96 0.34 8.14e-9 Airway imaging phenotypes; CESC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg01516881 chr6:292596 DUSP22 -0.49 -6.45 -0.37 5.17e-10 Menopause (age at onset); CESC cis rs116095464 0.558 rs73029475 chr5:206969 T/C cg22496380 chr5:211416 CCDC127 -0.95 -10.05 -0.53 2.34e-20 Breast cancer; CESC cis rs9430161 0.611 rs72644043 chr1:11033051 T/A cg27631724 chr1:11040367 C1orf127 0.38 6.21 0.36 2.02e-9 Ewing sarcoma; CESC cis rs7089973 0.966 rs61867966 chr10:116584362 T/C cg25233709 chr10:116636983 FAM160B1 0.37 5.3 0.31 2.47e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs72634258 0.945 rs12730860 chr1:8132462 T/C cg00042356 chr1:8021962 PARK7 0.78 7.36 0.41 2.34e-12 Inflammatory bowel disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06310300 chr7:100076089 TSC22D4 0.44 6.01 0.35 6.1e-9 Systemic lupus erythematosus; CESC cis rs4595586 0.545 rs12826080 chr12:39387772 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.6 0.42 4.97e-13 Morning vs. evening chronotype; CESC cis rs2072732 0.861 rs56398543 chr1:2950237 G/A cg15211996 chr1:2936768 ACTRT2 0.34 5.97 0.34 7.52e-9 Plateletcrit; CESC cis rs1348850 0.914 rs1975544 chr2:178465423 G/A cg23306229 chr2:178417860 TTC30B 0.56 6.72 0.38 1.08e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1595825 0.891 rs16866980 chr2:198513009 A/C cg10820045 chr2:198174542 NA 0.4 5.03 0.3 9.19e-7 Ulcerative colitis; CESC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.56 -6.94 -0.39 3e-11 Prudent dietary pattern; CESC cis rs870825 0.616 rs36022027 chr4:185639192 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.07 0.4 1.39e-11 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17978844 chr19:40854664 PLD3;C19orf47 -0.61 -6.77 -0.38 8.13e-11 Gut microbiome composition (summer); CESC cis rs12540874 0.698 rs3823674 chr7:50571996 C/T cg18232548 chr7:50535776 DDC -0.4 -5.7 -0.33 3.26e-8 Systemic sclerosis; CESC cis rs3015497 0.543 rs3015493 chr14:51124353 G/A cg26011998 chr14:51135199 SAV1 -0.6 -6.3 -0.36 1.26e-9 Mean platelet volume; CESC cis rs9894429 0.608 rs8477 chr17:79618059 C/T cg18240062 chr17:79603768 NPLOC4 0.51 6.53 0.37 3.32e-10 Eye color traits; CESC cis rs863345 0.604 rs10908674 chr1:158503920 A/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18342900 chr16:46865048 C16orf87 0.5 6.66 0.38 1.54e-10 Systemic lupus erythematosus; CESC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.99 -0.56 2.15e-23 Alzheimer's disease; CESC cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg17366294 chr4:99064904 C4orf37 0.58 8.14 0.45 1.52e-14 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.801 rs12798028 chr11:47604639 C/T cg05585544 chr11:47624801 NA -0.41 -6.44 -0.37 5.57e-10 Subjective well-being; CESC cis rs501120 0.925 rs492152 chr10:44757677 C/T cg09554077 chr10:44749378 NA 0.52 6.73 0.38 1.02e-10 Coronary artery disease;Coronary heart disease; CESC cis rs7116495 0.609 rs567026 chr11:71769952 C/T cg07596299 chr11:71824057 C11orf51 0.85 5.46 0.32 1.07e-7 Severe influenza A (H1N1) infection; CESC cis rs17253792 0.822 rs78824140 chr14:56042715 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.73 0.33 2.76e-8 Putamen volume; CESC cis rs78456975 0.527 rs10184112 chr2:1571112 A/G cg12573674 chr2:1569213 NA -0.47 -5.35 -0.31 1.93e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg21285383 chr16:89894308 SPIRE2 0.32 5.73 0.33 2.66e-8 Vitiligo; CESC cis rs4689592 0.587 rs3822269 chr4:7069901 T/C cg06697600 chr4:7070879 GRPEL1 -0.51 -7.32 -0.41 2.95e-12 Monocyte percentage of white cells; CESC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg11644478 chr21:40555479 PSMG1 -0.84 -12.62 -0.61 6.4e-29 Cognitive function; CESC cis rs8062405 1.000 rs62036621 chr16:28833299 C/A cg08761264 chr16:28874980 SH2B1 -0.47 -5.84 -0.34 1.55e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6558174 0.930 rs12676084 chr8:22493350 C/T cg03733263 chr8:22462867 KIAA1967 0.47 6.14 0.35 3.03e-9 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15004027 chr11:71823924 C11orf51 0.64 7.39 0.41 1.88e-12 Gut microbiome composition (summer); CESC cis rs1728785 1.000 rs1645928 chr16:68590610 G/T cg02972257 chr16:68554789 NA -0.67 -7.61 -0.42 4.84e-13 Ulcerative colitis; CESC cis rs1775715 0.870 rs1755084 chr10:32253709 C/T cg04359828 chr10:32216031 ARHGAP12 0.36 5.15 0.3 5.14e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6088580 0.634 rs6088512 chr20:33095891 G/A cg08999081 chr20:33150536 PIGU 0.65 11.45 0.58 6.19e-25 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16538604 chr4:2010703 WHSC2 0.63 7.6 0.42 5.18e-13 Gut microbiome composition (summer); CESC cis rs7592578 0.766 rs62182885 chr2:191437024 A/G cg27211696 chr2:191398769 TMEM194B -0.62 -5.43 -0.32 1.26e-7 Diastolic blood pressure; CESC cis rs10751667 0.600 rs4076915 chr11:1012464 C/G cg06064525 chr11:970664 AP2A2 -0.33 -5.58 -0.32 6.04e-8 Alzheimer's disease (late onset); CESC cis rs2404602 0.536 rs12915248 chr15:76765615 A/T cg26408565 chr15:76604113 ETFA -0.44 -6.6 -0.38 2.24e-10 Blood metabolite levels; CESC cis rs1413885 0.516 rs1591364 chr1:65842364 T/G cg14976592 chr1:65886160 LEPROT;LEPR 0.49 6.41 0.37 6.71e-10 Anticoagulant levels; CESC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.6 6.74 0.38 9.57e-11 IgG glycosylation; CESC trans rs629535 0.783 rs658407 chr8:70035247 T/C cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.02 11.26 0.57 2.8e-24 Platelet count; CESC cis rs2637266 0.875 rs12783253 chr10:78378108 A/G cg18941641 chr10:78392320 NA 0.42 7.97 0.44 4.89e-14 Pulmonary function; CESC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg07507251 chr3:52567010 NT5DC2 0.41 7.26 0.41 4.17e-12 Bipolar disorder; CESC cis rs1847202 0.859 rs4490296 chr3:72949197 C/A cg10804678 chr3:72788309 NA -0.39 -5.25 -0.31 3.19e-7 Motion sickness; CESC cis rs6460942 0.630 rs17670901 chr7:12386622 G/A cg20607287 chr7:12443886 VWDE -0.59 -6.42 -0.37 6.19e-10 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17956819 chr17:22191704 NA -0.51 -7.25 -0.41 4.62e-12 Gut microbiome composition (summer); CESC cis rs4835473 0.838 rs4583708 chr4:144656763 A/G cg25736465 chr4:144833511 NA -0.33 -5.21 -0.3 3.82e-7 Immature fraction of reticulocytes; CESC cis rs10242455 0.702 rs112475236 chr7:99044679 A/G cg18809830 chr7:99032528 PTCD1 -0.62 -5.14 -0.3 5.28e-7 Blood metabolite levels; CESC cis rs11608355 0.545 rs2302705 chr12:109898716 C/T cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs7100689 0.784 rs7895042 chr10:82095276 G/A cg09936400 chr10:82049201 MAT1A 0.37 5.28 0.31 2.63e-7 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07701033 chr12:49110781 CCNT1 0.57 6.62 0.38 1.94e-10 Gut microbiome composition (summer); CESC cis rs4718428 0.960 rs6460317 chr7:66390255 A/G cg12165864 chr7:66369176 NA -0.47 -5.57 -0.32 6.29e-8 Corneal structure; CESC cis rs7246657 0.943 rs10409204 chr19:37917692 G/A cg23950597 chr19:37808831 NA -0.62 -6.35 -0.36 9.22e-10 Coronary artery calcification; CESC cis rs12220238 1.000 rs10824151 chr10:76092179 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.08 0.3 7.3e-7 Soluble interleukin-2 receptor subunit alpha; CESC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg23590916 chr17:43697445 MGC57346 -0.6 -6.3 -0.36 1.23e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg25019033 chr10:957182 NA -0.6 -6.53 -0.37 3.42e-10 Eosinophil percentage of granulocytes; CESC cis rs6973256 0.569 rs9649595 chr7:133385921 G/C cg10665199 chr7:133106180 EXOC4 0.45 6.2 0.36 2.12e-9 Intelligence (multi-trait analysis); CESC cis rs4722166 0.630 rs4722169 chr7:22785419 C/T cg05472934 chr7:22766657 IL6 0.86 10.84 0.55 6.66e-23 Lung cancer; CESC cis rs617791 0.530 rs10791835 chr11:65750924 C/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.53 6.38 0.36 8.01e-10 Breast cancer; CESC cis rs15676 0.783 rs2977995 chr9:131584245 A/G cg00228799 chr9:131580591 ENDOG 0.55 7.13 0.4 9.74e-12 Blood metabolite levels; CESC cis rs10751667 0.714 rs7395879 chr11:963855 G/C cg20946044 chr11:1010712 AP2A2 -0.38 -5.35 -0.31 1.92e-7 Alzheimer's disease (late onset); CESC cis rs7481584 0.961 rs729662 chr11:3028140 G/A cg25174290 chr11:3078921 CARS -0.44 -5.53 -0.32 7.86e-8 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21722680 chr12:64846210 TBK1 -0.59 -6.36 -0.36 8.81e-10 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg12311346 chr5:56204834 C5orf35 -0.7 -8.66 -0.47 4.67e-16 Initial pursuit acceleration; CESC cis rs9487051 0.676 rs1608042 chr6:109595631 G/A cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg04518342 chr5:131593106 PDLIM4 -0.36 -5.21 -0.3 3.8e-7 Breast cancer; CESC trans rs3780486 0.846 rs73484568 chr9:33132492 G/A cg04842962 chr6:43655489 MRPS18A 1.01 19.52 0.77 3.23e-53 IgG glycosylation; CESC cis rs9796 0.870 rs11855248 chr15:41276158 G/A cg18705301 chr15:41695430 NDUFAF1 -0.47 -7.08 -0.4 1.29e-11 Menopause (age at onset); CESC cis rs1707322 1.000 rs4660905 chr1:46461587 C/T cg05343316 chr1:45956843 TESK2 -0.44 -5.42 -0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22264975 chr6:90121670 RRAGD -0.49 -6.37 -0.36 8.42e-10 Ulcerative colitis; CESC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg26343298 chr8:95960752 TP53INP1 0.35 5.76 0.33 2.29e-8 Type 2 diabetes; CESC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.17 -22.95 -0.82 6.46e-65 Prudent dietary pattern; CESC cis rs13034020 0.522 rs12998880 chr2:61240882 G/A cg18625361 chr2:61244694 PEX13;PUS10 0.66 5.9 0.34 1.13e-8 Hodgkin's lymphoma; CESC cis rs10883723 0.810 rs7090276 chr10:104281239 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.59 0.42 5.46e-13 Allergic disease (asthma, hay fever or eczema); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10937591 chr1:112532966 KCND3 0.43 6.21 0.36 2.08e-9 Fibrinogen levels; CESC cis rs832540 0.806 rs10039322 chr5:56260259 A/C cg12311346 chr5:56204834 C5orf35 -0.41 -5.29 -0.31 2.51e-7 Coronary artery disease; CESC cis rs863345 0.967 rs951135 chr1:158531633 A/T cg12129480 chr1:158549410 OR10X1 0.33 6.71 0.38 1.14e-10 Pneumococcal bacteremia; CESC cis rs16858210 0.874 rs73177525 chr3:183570286 G/C cg03417191 chr3:183542750 MAP6D1 -0.43 -5.54 -0.32 7.15e-8 Menopause (age at onset); CESC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.15 -0.4 8.37e-12 Total body bone mineral density; CESC trans rs7937682 0.814 rs1784788 chr11:111486136 T/G cg18187862 chr3:45730750 SACM1L 0.48 6.1 0.35 3.75e-9 Primary sclerosing cholangitis; CESC cis rs1950626 0.532 rs61991120 chr14:101455222 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.67 8.97 0.48 5.38e-17 Pelvic organ prolapse (moderate/severe); CESC trans rs561341 0.882 rs111484028 chr17:30287701 G/A cg27661571 chr11:113659931 NA -0.72 -7.36 -0.41 2.36e-12 Hip circumference adjusted for BMI; CESC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg27266027 chr21:40555129 PSMG1 -0.4 -5.13 -0.3 5.5e-7 Cognitive function; CESC cis rs6714710 0.603 rs17489984 chr2:98421364 A/G cg26665480 chr2:98280029 ACTR1B 0.6 8.26 0.45 6.99e-15 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs4474465 0.833 rs7934912 chr11:78218556 A/T cg27205649 chr11:78285834 NARS2 0.43 5.29 0.31 2.62e-7 Alzheimer's disease (survival time); CESC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg08736216 chr1:53307985 ZYG11A -0.37 -6.19 -0.36 2.27e-9 Monocyte count; CESC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg04511125 chr2:88470314 THNSL2 -0.54 -7.88 -0.44 8.42e-14 Response to metformin (IC50); CESC cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg23711669 chr6:146136114 FBXO30 -1.0 -15.05 -0.68 1.98e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs7246657 0.943 rs10422967 chr19:37850137 T/C cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg23803603 chr1:2058230 PRKCZ 0.3 5.21 0.31 3.73e-7 Height; CESC cis rs1185460 1.000 rs1784305 chr11:118942048 G/A cg23280166 chr11:118938394 VPS11 0.57 7.83 0.43 1.2e-13 Coronary artery disease; CESC cis rs11785693 0.862 rs62491202 chr8:5001470 C/A cg26367366 chr8:4980734 NA 0.83 7.77 0.43 1.77e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs11051970 0.592 rs11051987 chr12:32555406 C/T cg24626660 chr12:32551988 NA 0.36 5.27 0.31 2.77e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg09127314 chr1:152161683 NA 0.4 5.11 0.3 6.09e-7 Inflammatory skin disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03325406 chr16:74641227 GLG1 -0.43 -6.04 -0.35 5.13e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg25036284 chr2:26402008 FAM59B -0.61 -7.08 -0.4 1.31e-11 Gut microbiome composition (summer); CESC cis rs1348850 0.561 rs57986285 chr2:178468663 C/T cg23306229 chr2:178417860 TTC30B 0.8 7.71 0.43 2.61e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1448094 0.511 rs17279338 chr12:86162874 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.61 0.33 5.01e-8 Major depressive disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03013188 chr16:2126939 TSC2 0.46 6.03 0.35 5.34e-9 Fibrinogen levels; CESC cis rs7605827 0.930 rs4668926 chr2:15704944 C/T cg19274914 chr2:15703543 NA 0.3 5.27 0.31 2.86e-7 Educational attainment (years of education); CESC cis rs2276314 0.857 rs56230698 chr18:33628885 A/G cg19628046 chr18:33552617 C18orf21 0.49 5.38 0.31 1.63e-7 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7640424 0.649 rs11917909 chr3:107864673 G/A cg09227934 chr3:107805635 CD47 -0.42 -5.49 -0.32 9.25e-8 Body mass index; CESC cis rs6465657 0.903 rs11767962 chr7:97778576 C/T cg21770322 chr7:97807741 LMTK2 0.83 13.85 0.65 3.33e-33 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs62408225 0.890 rs2134814 chr6:90987512 C/G cg06866423 chr6:90926672 BACH2 0.45 5.41 0.32 1.42e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs6951245 0.678 rs28600085 chr7:1169636 C/T cg13565492 chr6:43139072 SRF -0.61 -6.51 -0.37 3.65e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3747547 0.892 rs3763637 chr9:38037956 T/A cg13774184 chr9:37916125 SHB -0.68 -5.72 -0.33 2.87e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs11785400 0.762 rs1137522 chr8:143739020 A/C cg24634471 chr8:143751801 JRK 0.45 5.75 0.33 2.41e-8 Schizophrenia; CESC cis rs12956009 0.518 rs3902716 chr18:44889441 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 7.0 0.39 2.11e-11 Educational attainment (years of education); CESC trans rs11722228 0.521 rs62288520 chr4:10099674 G/A cg26043149 chr18:55253948 FECH 0.92 10.95 0.56 2.93e-23 Gout;Urate levels;Serum uric acid levels; CESC cis rs9486715 0.838 rs9386576 chr6:96954717 C/T cg06623918 chr6:96969491 KIAA0776 0.93 14.38 0.66 4.75e-35 Headache; CESC cis rs9513627 1.000 rs3928270 chr13:100184268 A/G cg25919922 chr13:100150906 NA 0.65 5.12 0.3 5.9e-7 Obesity-related traits; CESC cis rs1691799 0.899 rs1168303 chr12:66738586 A/G cg16791601 chr12:66731901 HELB -0.75 -13.03 -0.62 2.51e-30 White blood cell count (basophil); CESC trans rs7615952 0.800 rs11915699 chr3:125632684 A/G cg07211511 chr3:129823064 LOC729375 -1.07 -14.66 -0.67 4.7e-36 Blood pressure (smoking interaction); CESC cis rs11711311 1.000 rs9865965 chr3:113450495 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.27 0.53 4.81e-21 IgG glycosylation; CESC cis rs7851660 0.967 rs12348691 chr9:100608682 G/A cg13688889 chr9:100608707 NA -0.68 -10.61 -0.55 3.8e-22 Strep throat; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12736146 chr10:116391608 ABLIM1 0.38 6.01 0.35 6.1e-9 Gambling; CESC cis rs72901758 0.768 rs11657271 chr17:76249682 A/T cg23302638 chr17:76210176 BIRC5 0.45 5.05 0.3 8.29e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs11608355 0.545 rs11612500 chr12:109897136 T/C cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs4835473 0.897 rs4423826 chr4:144913318 A/G cg25736465 chr4:144833511 NA 0.43 6.43 0.37 6.04e-10 Immature fraction of reticulocytes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10384294 chr12:57636980 NA 0.46 6.69 0.38 1.29e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs61931739 0.782 rs1197569 chr12:34186733 A/T cg19457237 chr12:34500585 NA -0.37 -5.19 -0.3 4.25e-7 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22395299 chr21:47706029 MCM3AP;C21orf57 -0.46 -6.25 -0.36 1.67e-9 Fibrinogen levels; CESC cis rs6964587 0.967 rs4626516 chr7:91807153 G/C cg17063962 chr7:91808500 NA 0.53 7.13 0.4 9.73e-12 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11809123 chr19:1584870 MBD3 0.5 6.41 0.37 6.51e-10 Fibrinogen levels; CESC cis rs10751667 0.600 rs1128413 chr11:1010694 C/T cg06064525 chr11:970664 AP2A2 -0.37 -6.23 -0.36 1.87e-9 Alzheimer's disease (late onset); CESC cis rs9911578 0.967 rs12603238 chr17:57130785 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -5.09 -0.3 6.91e-7 Intelligence (multi-trait analysis); CESC cis rs1879734 0.521 rs1879731 chr1:54175861 G/A cg23596471 chr1:54105337 GLIS1 0.32 5.17 0.3 4.7e-7 Mitral valve prolapse; CESC cis rs55883249 1.000 rs10495571 chr2:9736066 A/G cg23886495 chr2:9695866 ADAM17 0.57 5.41 0.32 1.39e-7 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs2562152 0.654 rs216600 chr16:110165 T/C cg02949481 chr16:131562 MPG 0.63 6.41 0.37 6.65e-10 Glioblastoma; CESC cis rs9457247 0.508 rs6941355 chr6:167506238 A/G cg07741184 chr6:167504864 NA 0.34 5.81 0.34 1.78e-8 Crohn's disease; CESC cis rs476633 0.691 rs28409265 chr15:41539404 G/A cg20272979 chr15:41787780 ITPKA 0.38 5.63 0.33 4.61e-8 Glomerular filtration rate (creatinine); CESC cis rs11098499 0.863 rs3822192 chr4:120445720 A/C cg09307838 chr4:120376055 NA 0.91 12.34 0.6 5.91e-28 Corneal astigmatism; CESC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.89 0.48 9.63e-17 Bipolar disorder; CESC cis rs919433 0.926 rs12618567 chr2:198148191 A/T cg10820045 chr2:198174542 NA -0.36 -5.17 -0.3 4.67e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7208859 0.623 rs9891166 chr17:29111902 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4319547 1.000 rs6489071 chr12:123025576 C/G cg05707623 chr12:122985044 ZCCHC8 -0.57 -6.72 -0.38 1.09e-10 Body mass index; CESC cis rs10789491 1.000 rs1371834 chr1:47176894 G/A cg15501359 chr1:47185051 KIAA0494 0.77 8.56 0.47 9.21e-16 Response to hepatitis C treatment; CESC cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg17211192 chr8:82754475 SNX16 -0.58 -7.38 -0.41 2.04e-12 Diastolic blood pressure; CESC cis rs3026101 0.671 rs1806256 chr17:5314357 A/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.47 0.32 1.04e-7 Body mass index; CESC cis rs3859192 0.561 rs34453912 chr17:38180352 T/A cg17344932 chr17:38183730 MED24;SNORD124 0.64 9.62 0.51 5.38e-19 White blood cell count; CESC cis rs9814567 1.000 rs6763093 chr3:134254995 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs10865397 0.506 rs6546807 chr2:73386212 C/T cg01422370 chr2:73384389 NA 0.46 7.35 0.41 2.47e-12 Intelligence (multi-trait analysis); CESC cis rs807669 0.524 rs11089258 chr22:19162276 C/T cg02655711 chr22:19163373 SLC25A1 0.43 6.32 0.36 1.09e-9 Metabolite levels; CESC cis rs4481887 0.893 rs28451623 chr1:248509783 G/A cg00666640 chr1:248458726 OR2T12 0.35 6.04 0.35 5.22e-9 Common traits (Other); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg18710692 chr13:20437712 ZMYM5 -0.48 -6.06 -0.35 4.63e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18986332 chr3:33759647 CLASP2 0.55 6.14 0.35 3.08e-9 Gut microbiome composition (summer); CESC cis rs1348850 0.567 rs3770009 chr2:178536544 C/T cg23306229 chr2:178417860 TTC30B 0.49 5.71 0.33 2.97e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg11494091 chr17:61959527 GH2 0.74 12.87 0.62 8.73e-30 Prudent dietary pattern; CESC trans rs1382269 0.551 rs1461514 chr3:136945045 G/A cg16900796 chr19:10755136 SLC44A2 -0.42 -6.32 -0.36 1.07e-9 Metabolite levels; CESC cis rs11711311 1.000 rs16861312 chr3:113492402 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.71 9.99 0.52 3.74e-20 IgG glycosylation; CESC cis rs12048904 0.595 rs10493937 chr1:101342650 A/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.46 -5.9 -0.34 1.11e-8 Multiple sclerosis; CESC cis rs10489202 1.000 rs2272911 chr1:167936302 C/T cg24449463 chr1:168025552 DCAF6 -0.46 -5.38 -0.31 1.63e-7 Schizophrenia; CESC cis rs11997175 0.766 rs4273817 chr8:33702686 C/T ch.8.33884649F chr8:33765107 NA 0.44 5.64 0.33 4.37e-8 Body mass index; CESC cis rs28489187 0.617 rs233124 chr1:85791658 A/G cg16011679 chr1:85725395 C1orf52 0.43 5.23 0.31 3.51e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs2066819 0.901 rs1274490 chr12:56649601 A/G cg26714650 chr12:56694279 CS 1.27 16.13 0.7 3.13e-41 Psoriasis vulgaris; CESC cis rs2243480 1.000 rs1499614 chr7:65730798 A/T cg13147721 chr7:65941812 NA -0.93 -8.87 -0.48 1.14e-16 Diabetic kidney disease; CESC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg06873352 chr17:61820015 STRADA 0.48 6.83 0.39 5.84e-11 Height; CESC cis rs79976124 0.837 rs74327235 chr6:66648353 T/A cg07460842 chr6:66804631 NA 0.75 8.76 0.47 2.33e-16 Type 2 diabetes; CESC cis rs9894429 0.646 rs6565612 chr17:79602820 C/T cg13777783 chr17:79615861 NA 0.37 6.26 0.36 1.55e-9 Eye color traits; CESC cis rs644799 0.965 rs549695 chr11:95617788 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.47 5.69 0.33 3.38e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.97 15.27 0.68 3.46e-38 Subjective well-being; CESC cis rs561341 1.000 rs8064843 chr17:30245744 A/G cg12193833 chr17:30244370 NA -0.55 -6.06 -0.35 4.53e-9 Hip circumference adjusted for BMI; CESC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.33 -0.31 2.07e-7 Developmental language disorder (linguistic errors); CESC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg03676636 chr4:99064102 C4orf37 0.37 5.67 0.33 3.68e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs11690935 0.632 rs12052246 chr2:172895606 G/T cg13550731 chr2:172543902 DYNC1I2 0.49 6.66 0.38 1.57e-10 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03849780 chr1:7816037 CAMTA1 0.41 6.21 0.36 2.06e-9 Fibrinogen levels; CESC cis rs2637266 0.655 rs846584 chr10:78495419 G/A cg18941641 chr10:78392320 NA 0.42 7.9 0.44 7.48e-14 Pulmonary function; CESC cis rs3947 1.000 rs709821 chr8:11702594 G/C cg00262122 chr8:11665843 FDFT1 -0.5 -5.1 -0.3 6.58e-7 Blood protein levels; CESC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg21951975 chr1:209979733 IRF6 -0.41 -7.2 -0.4 6.33e-12 Monobrow; CESC cis rs870825 0.655 rs28555435 chr4:185647300 C/A cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs6088590 0.561 rs6088528 chr20:33156742 G/A cg24642439 chr20:33292090 TP53INP2 0.64 8.54 0.46 1.05e-15 Coronary artery disease; CESC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg11764359 chr7:65958608 NA 0.89 13.11 0.63 1.31e-30 Aortic root size; CESC cis rs77861329 1.000 rs17051957 chr3:52099441 A/G cg08692210 chr3:52188851 WDR51A 0.71 6.75 0.38 9.45e-11 Macrophage inflammatory protein 1b levels; CESC trans rs1814175 0.935 rs7925863 chr11:49615802 C/A cg15704280 chr7:45808275 SEPT13 -1.01 -17.69 -0.74 8.95e-47 Height; CESC cis rs977987 0.872 rs4888422 chr16:75470576 A/G cg03315344 chr16:75512273 CHST6 0.4 5.91 0.34 1.07e-8 Dupuytren's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03258011 chr17:54857409 NA -0.44 -6.2 -0.36 2.18e-9 Gambling; CESC cis rs1707322 0.681 rs12048866 chr1:46117492 T/G cg05343316 chr1:45956843 TESK2 0.51 6.24 0.36 1.7e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2108225 0.872 rs2051955 chr7:107441154 C/T cg18560240 chr7:107437656 SLC26A3 -0.41 -5.67 -0.33 3.67e-8 Ulcerative colitis; CESC cis rs965469 0.779 rs6037568 chr20:3333245 C/T cg17110299 chr20:3385021 C20orf194 0.4 5.25 0.31 3.1e-7 IFN-related cytopenia; CESC cis rs11719291 0.915 rs1048940 chr3:48725707 C/T cg00383909 chr3:49044727 WDR6 0.85 5.26 0.31 2.96e-7 Cognitive function; CESC cis rs2228479 0.850 rs45524643 chr16:89815824 G/A cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs4566357 0.615 rs10178260 chr2:227914458 G/T cg11843606 chr2:227700838 RHBDD1 -0.46 -6.28 -0.36 1.38e-9 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25825740 chr17:80036910 FASN 0.34 6.35 0.36 9.3e-10 Gambling; CESC cis rs909002 0.830 rs10914460 chr1:32113216 T/C cg13919466 chr1:32135498 COL16A1 -0.47 -8.63 -0.47 5.6e-16 Intelligence (multi-trait analysis); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg01332181 chr19:47290716 SLC1A5 -0.44 -6.06 -0.35 4.66e-9 Recombination measurement; CESC cis rs752010 0.662 rs10890154 chr1:42106740 C/T cg06885757 chr1:42089581 HIVEP3 0.53 8.29 0.45 5.6e-15 Lupus nephritis in systemic lupus erythematosus; CESC cis rs6028335 0.674 rs16987712 chr20:37601243 A/G cg16355469 chr20:37678765 NA 0.52 5.14 0.3 5.28e-7 Alcohol and nicotine co-dependence; CESC cis rs34779708 0.931 rs4351760 chr10:35280254 A/G cg04310649 chr10:35416472 CREM -0.5 -6.06 -0.35 4.78e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7927771 0.965 rs1064608 chr11:47640429 G/C cg20307385 chr11:47447363 PSMC3 -0.49 -5.98 -0.34 7.21e-9 Subjective well-being; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05800723 chr4:79103126 FRAS1 -0.45 -6.04 -0.35 5.24e-9 Gut microbiota (bacterial taxa); CESC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.65 -8.68 -0.47 4.16e-16 Total body bone mineral density; CESC cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.18 0.3 4.42e-7 Colonoscopy-negative controls vs population controls; CESC cis rs78456975 0.527 rs11884165 chr2:1561052 A/G cg26248373 chr2:1572462 NA -0.58 -6.93 -0.39 3.29e-11 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg17294928 chr15:75287854 SCAMP5 0.52 6.64 0.38 1.77e-10 Caffeine consumption; CESC cis rs6446731 0.593 rs6446728 chr4:3275650 A/G cg08886695 chr4:3369023 RGS12 -0.39 -5.62 -0.33 4.77e-8 Mean platelet volume; CESC cis rs2070433 0.800 rs2073380 chr21:47863757 A/C cg12379764 chr21:47803548 PCNT 0.65 7.24 0.41 4.98e-12 Lymphocyte counts; CESC cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg26408565 chr15:76604113 ETFA -0.43 -6.19 -0.36 2.32e-9 Blood metabolite levels; CESC cis rs2243480 1.000 rs778729 chr7:65824419 T/C cg12463550 chr7:65579703 CRCP 0.71 5.49 0.32 9.37e-8 Diabetic kidney disease; CESC cis rs6500395 1.000 rs55671623 chr16:48631154 A/G cg04672837 chr16:48644449 N4BP1 0.51 6.51 0.37 3.71e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs12912251 0.591 rs2624272 chr15:39003409 A/G cg10631289 chr15:39006617 NA -0.45 -5.13 -0.3 5.5e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs5850 0.602 rs1005786 chr7:23145837 G/C cg23682824 chr7:23144976 KLHL7 0.46 6.2 0.36 2.13e-9 Blood protein levels; CESC cis rs7089973 0.966 rs12772800 chr10:116630962 A/G cg25233709 chr10:116636983 FAM160B1 0.38 5.42 0.32 1.36e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7264396 0.563 rs17092980 chr20:34289005 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.9 -10.87 -0.56 5.11e-23 Total cholesterol levels; CESC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg24562669 chr7:97807699 LMTK2 -0.49 -7.16 -0.4 8.14e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs11249608 0.548 rs34054398 chr5:178458371 A/G cg21905437 chr5:178450457 ZNF879 0.58 8.03 0.44 3.12e-14 Pubertal anthropometrics; CESC cis rs9303401 0.614 rs34900851 chr17:56566399 G/A cg25039879 chr17:56429692 SUPT4H1 0.51 5.08 0.3 7.18e-7 Cognitive test performance; CESC cis rs2710642 0.586 rs62180020 chr2:62819915 C/G cg17519650 chr2:63277830 OTX1 0.49 6.41 0.37 6.46e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs2243480 1.000 rs1723269 chr7:65472786 C/G cg18252515 chr7:66147081 NA -1.25 -12.29 -0.6 9.28e-28 Diabetic kidney disease; CESC cis rs12145833 0.538 rs61833885 chr1:243397188 C/A cg02356786 chr1:243265016 LOC731275 0.78 6.34 0.36 9.66e-10 Obesity (early onset extreme); CESC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg04369109 chr6:150039330 LATS1 -0.45 -6.17 -0.35 2.54e-9 Lung cancer; CESC cis rs9291683 0.546 rs4529049 chr4:10045389 C/T cg02734326 chr4:10020555 SLC2A9 0.45 6.27 0.36 1.46e-9 Bone mineral density; CESC cis rs7296418 0.699 rs11057219 chr12:123750073 T/C cg00376283 chr12:123451042 ABCB9 0.61 8.4 0.46 2.77e-15 Platelet count; CESC cis rs7246657 0.943 rs1373991 chr19:37838911 T/C cg23950597 chr19:37808831 NA -0.55 -6.09 -0.35 3.96e-9 Coronary artery calcification; CESC cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg13175981 chr1:150552382 MCL1 0.58 8.45 0.46 1.93e-15 Tonsillectomy; CESC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg11247378 chr22:39784982 NA -0.6 -8.99 -0.48 4.97e-17 Intelligence (multi-trait analysis); CESC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg07507251 chr3:52567010 NT5DC2 0.4 7.1 0.4 1.15e-11 Bipolar disorder; CESC cis rs3096299 0.967 rs11648663 chr16:89466307 C/T cg02187348 chr16:89574699 SPG7 0.51 6.81 0.39 6.62e-11 Multiple myeloma (IgH translocation); CESC cis rs2243480 1.000 rs2707844 chr7:66059509 G/A cg18252515 chr7:66147081 NA -1.39 -14.25 -0.66 1.31e-34 Diabetic kidney disease; CESC cis rs7914558 0.966 rs7921574 chr10:104840970 T/C cg15744005 chr10:104629667 AS3MT -0.32 -5.04 -0.3 8.72e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs910316 0.726 rs12882664 chr14:75446778 C/T cg08847533 chr14:75593920 NEK9 0.91 15.46 0.69 7.14e-39 Height; CESC cis rs1707322 0.752 rs12027622 chr1:46130252 A/C cg03146154 chr1:46216737 IPP 0.82 11.51 0.58 3.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11250098 0.574 rs7015168 chr8:10772210 G/C cg27411982 chr8:10470053 RP1L1 -0.43 -5.23 -0.31 3.43e-7 Morning vs. evening chronotype; CESC cis rs1957429 0.808 rs1951492 chr14:65346895 G/A cg23373153 chr14:65346875 NA 0.96 11.51 0.58 4.06e-25 Pediatric areal bone mineral density (radius); CESC cis rs3105593 1.000 rs2292174 chr15:50924956 A/G cg08437265 chr15:50716283 USP8 0.41 5.23 0.31 3.37e-7 QT interval; CESC cis rs2485892 0.553 rs4844954 chr1:210337043 A/G cg23283495 chr1:209979779 IRF6 0.47 5.77 0.33 2.21e-8 Manic episodes in bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07805240 chr7:8008383 GLCCI1 0.66 8.19 0.45 1.12e-14 Gut microbiome composition (summer); CESC cis rs10791323 0.569 rs5019134 chr11:133713082 G/C cg06766960 chr11:133703094 NA -0.4 -5.67 -0.33 3.7e-8 Childhood ear infection; CESC cis rs9479482 0.648 rs912557 chr6:150385977 C/T cg03788504 chr6:150331562 NA -0.31 -6.16 -0.35 2.74e-9 Alopecia areata; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg21959181 chr7:150755243 CDK5;SLC4A2 0.45 6.04 0.35 5.2e-9 Breast cancer;Type 2 diabetes; CESC cis rs13064411 0.696 rs13325046 chr3:113104444 C/T cg18753928 chr3:113234510 CCDC52 -0.47 -5.24 -0.31 3.31e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC trans rs1945213 0.694 rs7106894 chr11:55877315 T/C cg03929089 chr4:120376271 NA 0.73 6.95 0.39 2.82e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs2742234 0.541 rs61268333 chr10:43721370 G/A cg07801480 chr10:43725741 RASGEF1A -0.4 -5.24 -0.31 3.22e-7 Hirschsprung disease; CESC trans rs9929218 0.817 rs3118228 chr16:68710737 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -10.44 -0.54 1.35e-21 Colorectal cancer; CESC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg04181038 chr4:183730758 NA 0.63 7.08 0.4 1.26e-11 Pediatric autoimmune diseases; CESC cis rs3008870 1.000 rs2985797 chr1:67431499 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.1 -15.07 -0.68 1.75e-37 Lymphocyte percentage of white cells; CESC cis rs2072732 0.904 rs9661525 chr1:2952840 A/C cg15211996 chr1:2936768 ACTRT2 0.35 6.0 0.35 6.39e-9 Plateletcrit; CESC cis rs8070624 0.543 rs4299203 chr17:17878159 T/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.13 0.45 1.68e-14 Total body bone mineral density; CESC cis rs4604732 0.631 rs80319072 chr1:247626835 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.5.2119577R chr5:115940196 NA -0.56 -6.24 -0.36 1.71e-9 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg10691866 chr7:65817282 TPST1 0.33 5.49 0.32 9.61e-8 Aortic root size; CESC cis rs10504229 0.834 rs7015674 chr8:58153166 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -8.28 -0.45 6.05e-15 Developmental language disorder (linguistic errors); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01811315 chr17:4890515 CAMTA2 -0.5 -6.37 -0.36 8.35e-10 Ulcerative colitis; CESC cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg26818010 chr10:134567672 INPP5A -0.85 -10.65 -0.55 2.77e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2996428 0.667 rs113120570 chr1:3770450 G/C cg13057898 chr1:3703894 LRRC47 0.45 6.09 0.35 3.87e-9 Red cell distribution width; CESC cis rs3008870 0.755 rs1925410 chr1:67365230 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.63 -8.27 -0.45 6.4e-15 Lymphocyte percentage of white cells; CESC cis rs425277 0.916 rs414777 chr1:2101687 G/A cg04315214 chr1:2043799 PRKCZ -0.37 -5.26 -0.31 2.99e-7 Height; CESC cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg10556349 chr10:835070 NA 0.76 6.35 0.36 9.42e-10 Eosinophil percentage of granulocytes; CESC cis rs1355223 0.506 rs1509659 chr11:34865133 A/G cg11622362 chr11:34938112 PDHX;APIP 0.44 5.29 0.31 2.52e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg22039839 chr20:60777952 NA -0.47 -6.06 -0.35 4.59e-9 Systemic lupus erythematosus; CESC cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.04 10.15 0.53 1.18e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3806843 1.000 rs10053586 chr5:140210760 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.16 -0.3 4.84e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6691722 0.503 rs6667695 chr1:24707669 G/A cg02336364 chr1:24764700 NIPAL3 0.32 6.58 0.37 2.48e-10 Response to interferon beta in multiple sclerosis; CESC cis rs7666738 0.830 rs7678250 chr4:98922109 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC trans rs9929218 1.000 rs12443730 chr16:68804342 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -8.18 -0.45 1.17e-14 Colorectal cancer; CESC cis rs2439831 1.000 rs690316 chr15:43737880 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.81 11.74 0.59 6.47e-26 Lung cancer in ever smokers; CESC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.84 -9.27 -0.49 6.81e-18 Gut microbiome composition (summer); CESC cis rs35306767 0.904 rs35667562 chr10:950630 G/A cg20503657 chr10:835505 NA 1.07 9.84 0.52 1.13e-19 Eosinophil percentage of granulocytes; CESC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg14893161 chr1:205819251 PM20D1 0.88 14.7 0.67 3.54e-36 Menarche (age at onset); CESC cis rs36051895 0.530 rs7036833 chr9:5226484 G/A cg02405213 chr9:5042618 JAK2 -0.58 -6.95 -0.39 2.86e-11 Pediatric autoimmune diseases; CESC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg12463550 chr7:65579703 CRCP -0.48 -6.17 -0.35 2.6e-9 Aortic root size; CESC cis rs8077889 0.871 rs16940243 chr17:41900003 C/G cg26893861 chr17:41843967 DUSP3 0.77 10.22 0.53 6.78e-21 Triglycerides; CESC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.6 0.47 7.02e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg08027265 chr7:2291960 NA -0.45 -6.9 -0.39 3.88e-11 Bipolar disorder and schizophrenia; CESC cis rs4561483 0.843 rs35153773 chr16:11936317 C/T cg08843971 chr16:11963173 GSPT1 0.54 7.74 0.43 2.1e-13 Testicular germ cell tumor; CESC cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg19193384 chr17:30244184 NA -0.68 -6.43 -0.37 5.9e-10 Hip circumference adjusted for BMI; CESC cis rs2439831 0.702 rs3784275 chr15:44091386 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.66 6.51 0.37 3.73e-10 Lung cancer in ever smokers; CESC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg23283495 chr1:209979779 IRF6 0.53 6.17 0.35 2.58e-9 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27308707 chr10:91461150 KIF20B 0.59 6.54 0.37 3.22e-10 Gut microbiome composition (summer); CESC cis rs10242455 0.867 rs2687143 chr7:99320469 C/T cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs7927771 0.507 rs10838754 chr11:47758532 A/C cg20307385 chr11:47447363 PSMC3 0.61 8.65 0.47 5.14e-16 Subjective well-being; CESC cis rs2243480 1.000 rs1039664 chr7:65449716 T/G cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg17279839 chr7:150038598 RARRES2 0.52 6.07 0.35 4.36e-9 Blood protein levels;Circulating chemerin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15778497 chr17:80011823 GPS1 -0.46 -6.11 -0.35 3.47e-9 Gut microbiome composition (summer); CESC cis rs9902453 0.904 rs4528633 chr17:28356136 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.69 -0.47 3.79e-16 Coffee consumption (cups per day); CESC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg04756594 chr16:24857601 SLC5A11 -0.5 -5.81 -0.34 1.82e-8 Intelligence (multi-trait analysis); CESC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg06718696 chr17:78121285 EIF4A3 0.79 9.64 0.51 4.84e-19 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16761550 chr16:3029823 PKMYT1 -0.42 -6.58 -0.37 2.47e-10 Gambling; CESC cis rs3106136 0.933 rs34383543 chr4:95163792 T/C cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.8 -0.39 6.92e-11 Capecitabine sensitivity; CESC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg24879335 chr3:133465180 TF 0.38 6.48 0.37 4.34e-10 Iron status biomarkers; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08207256 chr19:10828848 DNM2;MIR638 -0.46 -6.52 -0.37 3.51e-10 Fibrinogen levels; CESC cis rs7264396 0.528 rs3787174 chr20:34487921 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -9.33 -0.5 4.49e-18 Total cholesterol levels; CESC cis rs2933343 0.649 rs2638845 chr3:128587369 A/G cg25356066 chr3:128598488 ACAD9 0.59 8.35 0.46 3.8e-15 IgG glycosylation; CESC cis rs8072100 1.000 rs4794016 chr17:45725931 T/A cg08085267 chr17:45401833 C17orf57 0.42 5.57 0.32 6.33e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6938 0.618 rs12901190 chr15:75231452 T/C cg09165964 chr15:75287851 SCAMP5 0.49 6.64 0.38 1.81e-10 Breast cancer; CESC cis rs2730245 0.510 rs2788471 chr7:158649786 G/T cg14689365 chr7:158441557 NCAPG2 0.42 5.21 0.31 3.71e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02176407 chr6:99282754 POU3F2 -0.64 -7.76 -0.43 1.83e-13 Gut microbiome composition (summer); CESC cis rs17539620 0.624 rs62432740 chr6:154836054 C/T cg20019720 chr6:154832845 CNKSR3 0.46 6.04 0.35 5.16e-9 Lipoprotein (a) levels; CESC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg03452623 chr4:187889614 NA -0.83 -14.22 -0.66 1.8e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg23281280 chr6:28129359 ZNF389 0.45 6.41 0.37 6.46e-10 Parkinson's disease; CESC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.87 0.44 9.16e-14 Menopause (age at onset); CESC cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg08392591 chr16:89556376 ANKRD11 0.61 8.29 0.45 5.92e-15 Multiple myeloma (IgH translocation); CESC cis rs11190604 1.000 rs79831012 chr10:102237059 T/C cg07080220 chr10:102295463 HIF1AN 0.55 5.59 0.33 5.51e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7605827 0.930 rs3732004 chr2:15713783 C/T cg19274914 chr2:15703543 NA 0.36 6.51 0.37 3.68e-10 Educational attainment (years of education); CESC cis rs7666738 0.830 rs10009206 chr4:99056900 A/C cg17366294 chr4:99064904 C4orf37 -0.41 -5.63 -0.33 4.56e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11601239 0.646 rs495498 chr11:105575774 C/T cg15315312 chr2:176867285 KIAA1715 -0.46 -6.17 -0.35 2.5e-9 Refractive error; CESC cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg25427524 chr10:38739819 LOC399744 -0.65 -9.48 -0.5 1.51e-18 Extrinsic epigenetic age acceleration; CESC cis rs11190604 1.000 rs3750629 chr10:102275727 A/G cg07080220 chr10:102295463 HIF1AN 0.67 6.49 0.37 4.31e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg23048001 chr7:2026167 MAD1L1 0.44 5.8 0.34 1.93e-8 Bipolar disorder and schizophrenia; CESC trans rs875971 0.508 rs10950045 chr7:66066373 T/C cg26939375 chr7:64535504 NA -0.53 -7.37 -0.41 2.22e-12 Aortic root size; CESC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.36 5.78 0.33 2.08e-8 Personality dimensions; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15985338 chr7:6048868 PMS2;AIMP2 -0.4 -6.15 -0.35 2.83e-9 Gambling; CESC cis rs60154123 0.772 rs701944 chr1:210417098 G/A cg25204440 chr1:209979598 IRF6 0.5 5.08 0.3 7.09e-7 Coronary artery disease; CESC cis rs4865169 0.934 rs3796531 chr4:57850846 A/G cg25525207 chr4:57843836 C4orf14;POLR2B 0.44 5.77 0.33 2.2e-8 Breast cancer; CESC cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.592 rs5758406 chr22:42076641 A/G cg06481639 chr22:41940642 POLR3H 0.6 6.3 0.36 1.21e-9 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18502306 chr4:8376764 ACOX3 -0.52 -6.07 -0.35 4.51e-9 Gut microbiome composition (summer); CESC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg13607699 chr17:42295918 UBTF 0.63 8.36 0.46 3.49e-15 Total body bone mineral density; CESC trans rs9945268 0.706 rs1452589 chr18:59336601 C/T cg24536146 chr1:207997166 NA 0.38 6.2 0.36 2.21e-9 Glomerular filtration rate (creatinine); CESC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg11890956 chr21:40555474 PSMG1 -0.93 -15.07 -0.68 1.72e-37 Cognitive function; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21451265 chr1:97187319 PTBP2 -0.46 -6.14 -0.35 3.05e-9 Ulcerative colitis; CESC trans rs17508449 0.821 rs1419231 chr1:114126218 C/G cg23028848 chr11:57092561 TNKS1BP1 -0.79 -6.17 -0.35 2.57e-9 Leprosy; CESC cis rs7089973 0.604 rs7914792 chr10:116591391 T/C cg23260525 chr10:116636907 FAM160B1 0.4 7.19 0.4 6.76e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20861091 chr8:144881744 SCRIB 0.44 6.63 0.38 1.88e-10 Fibrinogen levels; CESC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg04414720 chr1:150670196 GOLPH3L 0.58 7.56 0.42 6.44e-13 Melanoma; CESC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs3820068 0.603 rs927207 chr1:15990552 A/G cg18133145 chr1:16060689 PLEKHM2 -0.41 -5.22 -0.31 3.64e-7 Systolic blood pressure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06090383 chr4:174292579 SAP30 0.51 6.58 0.37 2.48e-10 Gut microbiota (bacterial taxa); CESC cis rs933688 1.000 rs2839728 chr5:90727412 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.1 14.79 0.67 1.76e-36 Smoking behavior; CESC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg22920501 chr2:26401640 FAM59B 0.86 9.98 0.52 3.93e-20 Gut microbiome composition (summer); CESC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg22903657 chr4:1355424 KIAA1530 -0.38 -5.23 -0.31 3.48e-7 Obesity-related traits; CESC cis rs6459788 0.605 rs887628 chr7:157237589 G/A cg06271696 chr7:157225062 NA -0.39 -5.45 -0.32 1.13e-7 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.42 5.68 0.33 3.55e-8 Bipolar disorder; CESC cis rs7116495 0.881 rs7128974 chr11:71677032 C/G cg26138937 chr11:71823887 C11orf51 0.84 6.8 0.39 6.89e-11 Severe influenza A (H1N1) infection; CESC cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.681 rs2270461 chr16:89972345 C/T cg04013166 chr16:89971882 TCF25 -0.74 -9.23 -0.49 8.91e-18 Skin colour saturation; CESC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg21226059 chr5:178986404 RUFY1 0.45 6.49 0.37 4.22e-10 Lung cancer; CESC cis rs6546537 0.550 rs2312202 chr2:69775104 A/C cg10773587 chr2:69614142 GFPT1 0.4 5.12 0.3 6.02e-7 Serum thyroid-stimulating hormone levels; CESC cis rs7264396 0.836 rs6088880 chr20:34165582 G/C cg04508476 chr20:34239394 CPNE1;RBM12 0.57 7.05 0.4 1.52e-11 Total cholesterol levels; CESC cis rs6088580 0.634 rs11700221 chr20:32940320 T/C cg24642439 chr20:33292090 TP53INP2 -0.52 -6.79 -0.38 7.44e-11 Glomerular filtration rate (creatinine); CESC cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg23324259 chr8:82754387 SNX16 -0.42 -5.17 -0.3 4.62e-7 Diastolic blood pressure; CESC cis rs35306767 0.903 rs12764024 chr10:922861 A/G cg26597838 chr10:835615 NA 0.82 8.91 0.48 8.55e-17 Eosinophil percentage of granulocytes; CESC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg01448562 chr3:133502909 NA -0.47 -6.26 -0.36 1.59e-9 Iron status biomarkers; CESC cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg12386194 chr3:101231763 SENP7 0.58 6.54 0.37 3.24e-10 Colonoscopy-negative controls vs population controls; CESC trans rs10435719 0.902 rs6601633 chr8:11805173 C/T cg15556689 chr8:8085844 FLJ10661 -0.53 -6.68 -0.38 1.38e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg25987502 chr17:6899865 ALOX12 0.45 7.4 0.41 1.86e-12 Tonsillectomy; CESC trans rs1003719 0.715 rs762139 chr21:38568475 A/T cg05556477 chr5:131705319 SLC22A5 -0.43 -6.09 -0.35 3.98e-9 Eye color traits; CESC cis rs225245 0.765 rs226428 chr17:34049950 C/T cg05299278 chr17:33885742 SLFN14 -0.37 -5.2 -0.3 3.91e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC trans rs2727020 0.521 rs937430 chr11:49542457 A/G cg15704280 chr7:45808275 SEPT13 0.85 10.76 0.55 1.2e-22 Coronary artery disease; CESC cis rs262150 0.851 rs2527224 chr7:158769198 G/A cg19418458 chr7:158789849 NA -0.49 -7.9 -0.44 7.61e-14 Facial morphology (factor 20); CESC cis rs9660180 0.839 rs12040826 chr1:1705287 A/C cg05132306 chr1:1846340 CALML6 -0.32 -6.73 -0.38 1.03e-10 Body mass index; CESC cis rs2742234 0.910 rs2505505 chr10:43648221 G/T cg07801480 chr10:43725741 RASGEF1A 0.39 5.65 0.33 4.23e-8 Hirschsprung disease; CESC cis rs6424115 1.000 rs974698 chr1:24132785 C/T cg15997130 chr1:24165203 NA 0.44 6.22 0.36 1.89e-9 Immature fraction of reticulocytes; CESC cis rs4689592 0.622 rs2276968 chr4:7070118 T/G cg06697600 chr4:7070879 GRPEL1 -0.59 -8.07 -0.44 2.46e-14 Monocyte percentage of white cells; CESC cis rs1790761 0.587 rs4930430 chr11:67294198 A/G cg14500267 chr11:67383377 NA 0.31 5.19 0.3 4.09e-7 Mean corpuscular volume; CESC cis rs7659604 0.592 rs56077950 chr4:122721412 C/T cg19748678 chr4:122722346 EXOSC9 0.76 9.57 0.51 7.84e-19 Type 2 diabetes; CESC cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg12365402 chr11:9010492 NRIP3 0.41 6.48 0.37 4.48e-10 Hemoglobin concentration; CESC cis rs11864453 0.713 rs9926156 chr16:72142895 G/C cg16558253 chr16:72132732 DHX38 -0.55 -8.69 -0.47 3.9e-16 Fibrinogen levels; CESC cis rs2228479 0.557 rs34420680 chr16:89809171 C/T cg00800038 chr16:89945340 TCF25 -0.9 -7.34 -0.41 2.63e-12 Skin colour saturation; CESC cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.9 0.34 1.09e-8 Colonoscopy-negative controls vs population controls; CESC cis rs34638657 0.872 rs2911423 chr16:82188801 C/T cg09439754 chr16:82129088 HSD17B2 -0.35 -5.22 -0.31 3.56e-7 Lung adenocarcinoma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00910521 chr17:75484950 SEPT9 0.46 6.14 0.35 2.99e-9 Fibrinogen levels; CESC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg06601766 chr17:61851465 DDX42;CCDC47 -0.54 -6.77 -0.38 8.1e-11 Prudent dietary pattern; CESC cis rs10876993 0.890 rs774891 chr12:58068571 G/A cg18357645 chr12:58087776 OS9 0.64 10.4 0.54 1.84e-21 Celiac disease or Rheumatoid arthritis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10733145 chr11:60673895 PRPF19 -0.41 -6.13 -0.35 3.09e-9 Gambling; CESC cis rs7918232 0.662 rs10764662 chr10:27300643 T/A cg14240646 chr10:27532245 ACBD5 -0.49 -5.26 -0.31 2.91e-7 Breast cancer; CESC cis rs4268898 0.662 rs72793967 chr2:24422902 C/T cg20701182 chr2:24300061 SF3B14 0.68 7.2 0.4 6.23e-12 Asthma; CESC cis rs8062405 0.755 rs17640009 chr16:28595700 A/G cg07382826 chr16:28625726 SULT1A1 0.4 6.52 0.37 3.55e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs79839061 0.610 rs11733713 chr4:869169 A/G cg07828340 chr4:882639 GAK 1.07 8.24 0.45 7.96e-15 Intelligence (multi-trait analysis); CESC cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg00033643 chr7:134001901 SLC35B4 0.44 5.59 0.32 5.6e-8 Mean platelet volume; CESC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.42 -5.47 -0.32 1.05e-7 Menarche (age at onset); CESC cis rs4835473 0.868 rs4350958 chr4:144665809 A/G cg25736465 chr4:144833511 NA 0.42 6.09 0.35 3.98e-9 Immature fraction of reticulocytes; CESC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg03709012 chr19:19516395 GATAD2A 0.96 13.95 0.65 1.59e-33 Tonsillectomy; CESC cis rs7772486 0.790 rs1062068 chr6:146207465 A/G cg23711669 chr6:146136114 FBXO30 0.94 13.72 0.64 9.92e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs6831352 0.918 rs13112733 chr4:100050319 A/T cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs8067354 0.574 rs1292033 chr17:57990597 A/T cg02344993 chr17:57696989 CLTC 0.52 5.45 0.32 1.15e-7 Hemoglobin concentration; CESC cis rs2425143 1.000 rs6060639 chr20:34438183 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.72 0.33 2.88e-8 Blood protein levels; CESC cis rs568617 1.000 rs694994 chr11:65653309 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.66 6.97 0.39 2.5e-11 Crohn's disease; CESC cis rs1707322 0.964 rs796773 chr1:46564475 C/T cg03146154 chr1:46216737 IPP -0.69 -9.13 -0.49 1.84e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg12365402 chr11:9010492 NRIP3 0.33 5.15 0.3 5.08e-7 Hemoglobin concentration; CESC cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.56 0.32 6.75e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4974559 0.947 rs28711287 chr4:1346682 G/C cg02980000 chr4:1222292 CTBP1 0.7 6.44 0.37 5.66e-10 Systolic blood pressure; CESC cis rs225245 0.782 rs225272 chr17:33969911 T/C cg05299278 chr17:33885742 SLFN14 0.38 5.48 0.32 1e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs561341 1.000 rs8077092 chr17:30281992 T/C cg00745463 chr17:30367425 LRRC37B -0.7 -7.02 -0.4 1.9e-11 Hip circumference adjusted for BMI; CESC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg16325326 chr1:53192061 ZYG11B 0.81 12.79 0.62 1.76e-29 Monocyte count; CESC cis rs950776 0.518 rs28438420 chr15:78836288 A/T cg24631222 chr15:78858424 CHRNA5 0.4 5.4 0.31 1.51e-7 Sudden cardiac arrest; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03981592 chr3:86061698 CADM2 0.46 6.54 0.37 3.08e-10 Fibrinogen levels; CESC cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg04455712 chr21:45112962 RRP1B 0.34 5.08 0.3 7.2e-7 Mean corpuscular volume; CESC cis rs3820068 0.559 rs6675334 chr1:15923580 A/T cg16988262 chr1:15930761 NA 0.34 5.46 0.32 1.12e-7 Systolic blood pressure; CESC cis rs9611565 0.921 rs2281332 chr22:41746212 T/C cg03806693 chr22:41940476 POLR3H -0.71 -8.5 -0.46 1.39e-15 Vitiligo; CESC cis rs929354 0.772 rs1182365 chr7:157017255 A/T cg05182265 chr7:156933206 UBE3C 0.5 7.32 0.41 2.97e-12 Body mass index; CESC cis rs11997175 0.583 rs12680755 chr8:33815282 G/A ch.8.33884649F chr8:33765107 NA 0.45 5.69 0.33 3.31e-8 Body mass index; CESC cis rs7727544 0.735 rs4705933 chr5:131678412 G/A cg24060327 chr5:131705240 SLC22A5 -0.67 -9.0 -0.48 4.57e-17 Blood metabolite levels; CESC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg11494091 chr17:61959527 GH2 0.72 12.33 0.6 6.37e-28 Prudent dietary pattern; CESC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg11890956 chr21:40555474 PSMG1 1.21 24.48 0.83 5.49e-70 Cognitive function; CESC trans rs4843747 0.708 rs11866437 chr16:88072279 A/G cg26811252 chr16:29126840 RRN3P2 -0.6 -8.5 -0.46 1.37e-15 Menopause (age at onset); CESC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12545109 0.700 rs2670045 chr8:57393695 A/G cg09654669 chr8:57350985 NA -0.57 -7.31 -0.41 3.08e-12 Obesity-related traits; CESC trans rs1814175 0.647 rs10839394 chr11:49844747 T/C cg03929089 chr4:120376271 NA -0.92 -15.46 -0.69 6.97e-39 Height; CESC cis rs9899728 0.520 rs12936866 chr17:73052050 A/G cg27626185 chr17:73056755 KCTD2 -0.95 -8.43 -0.46 2.23e-15 Alzheimer's disease or small vessel stroke; CESC trans rs1814175 0.817 rs11040474 chr11:49708441 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.23 -0.76 3.56e-52 Height; CESC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.06 -12.34 -0.6 5.85e-28 Gut microbiome composition (summer); CESC cis rs2404602 0.530 rs12915184 chr15:76965922 G/A cg00316803 chr15:76480434 C15orf27 0.44 5.94 0.34 8.86e-9 Blood metabolite levels; CESC cis rs12477438 1.000 rs17760953 chr2:99859863 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -7.71 -0.43 2.5e-13 Chronic sinus infection; CESC cis rs72781680 1.000 rs963725 chr2:24148231 T/C cg20701182 chr2:24300061 SF3B14 0.78 6.73 0.38 1.07e-10 Lymphocyte counts; CESC cis rs5758659 0.594 rs739292 chr22:42368857 G/A cg04733989 chr22:42467013 NAGA 0.44 5.82 0.34 1.72e-8 Cognitive function; CESC cis rs2228479 0.850 rs17233664 chr16:89810628 C/T cg19635926 chr16:89946313 TCF25 0.66 5.04 0.3 8.52e-7 Skin colour saturation; CESC cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.82 0.34 1.74e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg17376030 chr22:41985996 PMM1 0.75 8.07 0.44 2.45e-14 Vitiligo; CESC cis rs8050907 0.590 rs1362627 chr16:4551505 C/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.8 5.41 0.32 1.44e-7 Obesity-related traits; CESC cis rs28489187 0.617 rs233118 chr1:85787967 C/T cg16011679 chr1:85725395 C1orf52 -0.47 -5.79 -0.33 2.03e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.22 -0.31 3.6e-7 Total body bone mineral density; CESC cis rs6662572 0.686 rs72690855 chr1:46266210 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.04 0.3 8.63e-7 Blood protein levels; CESC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.6 0.47 6.99e-16 Menopause (age at onset); CESC cis rs561341 0.714 rs474455 chr17:30312465 A/T cg12193833 chr17:30244370 NA -0.58 -5.88 -0.34 1.21e-8 Hip circumference adjusted for BMI; CESC cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg05639522 chr1:247681581 NA 0.46 6.02 0.35 5.84e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs11711311 1.000 rs4362695 chr3:113534856 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.56 7.46 0.42 1.25e-12 IgG glycosylation; CESC cis rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05883489 chr16:57334690 NA -0.39 -5.66 -0.33 3.85e-8 Gambling; CESC trans rs7829975 0.774 rs11775523 chr8:8679176 A/G cg21775007 chr8:11205619 TDH 0.41 6.04 0.35 5.3e-9 Mood instability; CESC cis rs7208859 0.623 rs56095789 chr17:29060170 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4268898 0.862 rs11125549 chr2:24576240 C/T cg20701182 chr2:24300061 SF3B14 -0.46 -5.55 -0.32 6.95e-8 Asthma; CESC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg21784768 chr11:537496 LRRC56 -0.54 -5.1 -0.3 6.36e-7 Body mass index; CESC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg02353165 chr6:42928485 GNMT 0.86 13.71 0.64 1.03e-32 Alzheimer's disease in APOE e4+ carriers; CESC cis rs73206853 0.841 rs9783428 chr12:111068096 C/T cg12870014 chr12:110450643 ANKRD13A 0.62 5.14 0.3 5.45e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs447 0.943 rs10808306 chr7:83767093 G/A cg22846510 chr7:83753280 SEMA3A -0.47 -5.74 -0.33 2.53e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7267979 0.866 rs2424698 chr20:25256106 C/T cg08601574 chr20:25228251 PYGB 0.4 5.71 0.33 3.01e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7267979 0.903 rs6050481 chr20:25224580 C/T cg08601574 chr20:25228251 PYGB 0.44 6.36 0.36 8.57e-10 Liver enzyme levels (alkaline phosphatase); CESC cis rs17376456 0.877 rs28418572 chr5:93144161 A/C cg25358565 chr5:93447407 FAM172A 1.09 10.74 0.55 1.41e-22 Diabetic retinopathy; CESC cis rs5753618 0.509 rs5749229 chr22:31587218 T/C cg13145458 chr22:31556086 RNF185 0.49 5.52 0.32 7.94e-8 Colorectal cancer; CESC trans rs801193 1.000 rs2055682 chr7:66260289 A/G cg26939375 chr7:64535504 NA 0.61 7.96 0.44 4.99e-14 Aortic root size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09129563 chr1:179198950 ABL2 -0.52 -6.38 -0.36 8.05e-10 Ulcerative colitis; CESC cis rs881375 0.669 rs73541868 chr9:123639264 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.17 0.4 7.35e-12 Rheumatoid arthritis; CESC cis rs2070488 0.804 rs13092164 chr3:38458533 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.81 13.01 0.62 2.92e-30 Electrocardiographic conduction measures; CESC cis rs1005224 0.864 rs11625011 chr14:76144828 G/A cg25116370 chr14:76127843 TTLL5;C14orf1 -0.41 -5.65 -0.33 4.13e-8 Large artery stroke; CESC cis rs12410462 0.581 rs12402691 chr1:227543693 G/A cg10327440 chr1:227177885 CDC42BPA -0.68 -5.72 -0.33 2.8e-8 Major depressive disorder; CESC cis rs1580019 0.961 rs4357201 chr7:32496333 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.15 0.53 1.14e-20 Cognitive ability; CESC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg13647721 chr17:30228624 UTP6 -0.65 -6.26 -0.36 1.57e-9 Hip circumference adjusted for BMI; CESC cis rs1691799 0.899 rs4762091 chr12:66747863 A/G cg16791601 chr12:66731901 HELB -0.79 -14.26 -0.66 1.23e-34 White blood cell count (basophil); CESC cis rs2243480 1.000 rs58062456 chr7:65394852 G/T cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs2072732 0.706 rs112690788 chr1:2954055 A/G cg03976712 chr1:2946727 NA 0.34 5.63 0.33 4.57e-8 Plateletcrit; CESC cis rs3540 0.512 rs17263706 chr15:91078803 G/T cg10434728 chr15:90938212 IQGAP1 0.38 6.48 0.37 4.35e-10 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs9534288 0.797 rs2404729 chr13:46617368 C/T cg11225435 chr1:211849015 NEK2 0.46 6.04 0.35 5.27e-9 Blood protein levels; CESC cis rs7296418 0.961 rs10773921 chr12:123541606 C/T cg05973401 chr12:123451056 ABCB9 0.58 7.67 0.43 3.25e-13 Platelet count; CESC cis rs929354 1.000 rs8101 chr7:157061474 A/G cg05182265 chr7:156933206 UBE3C 0.42 5.77 0.33 2.25e-8 Body mass index; CESC cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 5.99 0.35 6.79e-9 Eosinophil percentage of white cells; CESC cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg11752832 chr7:134001865 SLC35B4 -0.52 -6.66 -0.38 1.57e-10 Mean platelet volume; CESC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg00339695 chr16:24857497 SLC5A11 0.52 6.26 0.36 1.5e-9 Intelligence (multi-trait analysis); CESC cis rs2730245 0.527 rs2657362 chr7:158685095 A/G cg24397884 chr7:158709396 WDR60 0.85 8.84 0.48 1.41e-16 Height; CESC cis rs7524258 0.868 rs6693725 chr1:7307810 G/T cg07173049 chr1:7289937 CAMTA1 0.39 6.21 0.36 2.05e-9 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs9399135 0.935 rs949547 chr6:135343499 C/G cg22676075 chr6:135203613 NA 0.51 7.36 0.41 2.34e-12 Red blood cell count; CESC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs712039 0.652 rs1616371 chr17:35773799 A/G cg16670864 chr17:35848621 DUSP14 0.42 5.31 0.31 2.32e-7 Tuberculosis; CESC trans rs208515 0.525 rs12204706 chr6:66669930 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.87 -11.26 -0.57 2.77e-24 Exhaled nitric oxide levels; CESC cis rs2204008 0.640 rs11520199 chr12:38211026 T/C cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs790123 1.000 rs2650950 chr3:122382048 C/T cg17380795 chr3:122379686 NA 0.35 5.19 0.3 4.17e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs17347800 1.000 rs17347800 chr7:18517279 A/G cg12093519 chr7:19146441 NA 0.64 5.31 0.31 2.34e-7 Stroke; CESC cis rs9911578 0.967 rs2611781 chr17:56703124 C/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.06 -0.4 1.44e-11 Intelligence (multi-trait analysis); CESC cis rs6546550 0.935 rs13017134 chr2:70090579 C/G cg02498382 chr2:70120550 SNRNP27 -0.35 -6.07 -0.35 4.29e-9 Prevalent atrial fibrillation; CESC cis rs7520050 0.966 rs61102033 chr1:46382441 G/T cg24296786 chr1:45957014 TESK2 0.43 5.43 0.32 1.25e-7 Red blood cell count;Reticulocyte count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17805752 chr15:40675029 C15orf23 -0.49 -6.22 -0.36 1.88e-9 Ulcerative colitis; CESC cis rs1707322 1.000 rs3922886 chr1:46473902 A/T cg06784218 chr1:46089804 CCDC17 0.34 5.75 0.33 2.49e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg05617483 chr15:76483344 C15orf27 0.43 5.97 0.34 7.67e-9 Blood metabolite levels; CESC cis rs73110464 0.609 rs11170348 chr12:53355588 A/G cg05393297 chr12:53359155 NA -0.71 -10.18 -0.53 9.24e-21 Cancer (pleiotropy); CESC cis rs7851660 0.679 rs7033765 chr9:100591705 A/T cg13688889 chr9:100608707 NA 0.57 8.86 0.48 1.2e-16 Strep throat; CESC cis rs765787 0.505 rs1648302 chr15:45494238 A/G cg24006582 chr15:45444508 DUOX1 -0.53 -6.66 -0.38 1.56e-10 Uric acid levels; CESC cis rs933688 0.938 rs7708782 chr5:90718517 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 12.44 0.61 2.82e-28 Smoking behavior; CESC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg06481639 chr22:41940642 POLR3H -0.65 -6.66 -0.38 1.54e-10 Vitiligo; CESC trans rs7246657 0.943 rs10405407 chr19:37839164 C/T cg24637308 chr11:6592297 DNHD1 0.53 6.17 0.35 2.55e-9 Coronary artery calcification; CESC cis rs10242455 0.702 rs73711280 chr7:99039604 C/T cg18809830 chr7:99032528 PTCD1 -0.63 -5.13 -0.3 5.68e-7 Blood metabolite levels; CESC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg03188948 chr7:1209495 NA 0.57 5.52 0.32 7.89e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs79057730 0.639 rs6463933 chr7:793954 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.66 5.82 0.34 1.73e-8 Initial pursuit acceleration; CESC cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg11752832 chr7:134001865 SLC35B4 0.55 7.23 0.41 5.27e-12 Mean platelet volume; CESC cis rs67311347 1.000 rs7633809 chr3:40517737 A/G cg01475735 chr3:40494733 NA 0.42 5.24 0.31 3.33e-7 Renal cell carcinoma; CESC cis rs4699052 0.599 rs11938459 chr4:104233989 T/C cg16532752 chr4:104119610 CENPE -0.37 -5.23 -0.31 3.45e-7 Testicular germ cell tumor; CESC cis rs1882538 0.538 rs9649587 chr7:133104569 A/C cg10665199 chr7:133106180 EXOC4 0.6 8.33 0.46 4.47e-15 Intelligence (multi-trait analysis); CESC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.76 0.38 8.98e-11 Bipolar disorder; CESC cis rs18122 0.846 rs6743811 chr2:67620157 C/A cg09028215 chr2:67624308 ETAA1 -0.43 -5.41 -0.32 1.39e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7589342 0.791 rs4438504 chr2:106461035 A/C cg16077055 chr2:106428750 NCK2 0.51 7.19 0.4 6.6e-12 Addiction; CESC cis rs9908102 0.710 rs8072647 chr17:12914516 T/C cg26162695 chr17:12921313 ELAC2 0.51 5.47 0.32 1.03e-7 Schizophrenia; CESC cis rs2276314 0.857 rs28435069 chr18:33628475 A/G cg05985134 chr18:33552581 C18orf21 0.63 7.59 0.42 5.58e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs933688 1.000 rs35712350 chr5:90679519 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 1.02 14.19 0.66 2.26e-34 Smoking behavior; CESC cis rs6460942 0.908 rs73301032 chr7:12256799 C/G cg06484146 chr7:12443880 VWDE -0.55 -5.68 -0.33 3.58e-8 Coronary artery disease; CESC cis rs7100689 0.622 rs1890890 chr10:82090643 A/T cg00277334 chr10:82204260 NA -0.6 -7.88 -0.44 8.54e-14 Post bronchodilator FEV1; CESC cis rs7927771 1.000 rs2290850 chr11:47807774 T/C cg18512352 chr11:47633146 NA -0.61 -9.7 -0.51 3.18e-19 Subjective well-being; CESC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg14393609 chr7:65229607 NA -0.44 -5.82 -0.34 1.67e-8 Aortic root size; CESC cis rs2439831 0.850 rs28696802 chr15:44140395 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.46 0.42 1.21e-12 Lung cancer in ever smokers; CESC cis rs896854 0.517 rs10112447 chr8:95955701 C/T cg13393036 chr8:95962371 TP53INP1 -0.45 -8.26 -0.45 6.81e-15 Type 2 diabetes; CESC cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg01017244 chr2:74357527 NA 0.67 9.66 0.51 4.19e-19 Gestational age at birth (maternal effect); CESC cis rs7666738 0.830 rs11947578 chr4:98930462 T/G cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.05 -0.4 1.54e-11 Total body bone mineral density; CESC cis rs7223966 0.961 rs35844156 chr17:61837568 G/A cg11494091 chr17:61959527 GH2 0.4 5.3 0.31 2.42e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg17724175 chr1:150552817 MCL1 0.44 7.23 0.41 5.25e-12 Tonsillectomy; CESC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg11764359 chr7:65958608 NA -0.95 -14.12 -0.66 3.94e-34 Aortic root size; CESC cis rs4820539 1.000 rs5759595 chr22:23471624 G/A cg14186256 chr22:23484241 RTDR1 0.83 15.0 0.68 3.09e-37 Bone mineral density; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg18402987 chr7:1209562 NA 0.44 5.74 0.33 2.56e-8 Longevity;Endometriosis; CESC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg12641515 chr19:46296257 DMWD 0.74 9.95 0.52 5e-20 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01908177 chr3:113005203 BOC -0.52 -6.16 -0.35 2.67e-9 Gut microbiome composition (summer); CESC cis rs9818941 0.824 rs2712318 chr3:157776053 C/T cg08654915 chr3:157813417 NA -0.49 -7.64 -0.43 3.87e-13 Height; CESC cis rs4919087 0.926 rs7072078 chr10:99026509 G/A cg25902810 chr10:99078978 FRAT1 0.67 9.75 0.51 2.23e-19 Monocyte count; CESC cis rs2204008 0.905 rs8189449 chr12:38437377 C/A cg26384229 chr12:38710491 ALG10B 0.64 9.46 0.5 1.69e-18 Bladder cancer; CESC cis rs4253772 0.530 rs9627387 chr22:46684678 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.78 9.5 0.5 1.27e-18 LDL cholesterol;Cholesterol, total; CESC trans rs11098499 0.754 rs12507565 chr4:120251121 G/A cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg05535760 chr7:792225 HEATR2 0.92 10.51 0.54 7.81e-22 Cerebrospinal P-tau181p levels; CESC cis rs2404602 0.692 rs35395069 chr15:76986334 C/T cg26408565 chr15:76604113 ETFA -0.39 -5.56 -0.32 6.68e-8 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15162335 chr12:21654546 RECQL;GOLT1B 0.63 6.82 0.39 5.98e-11 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg07507251 chr3:52567010 NT5DC2 0.32 5.61 0.33 5.12e-8 Bipolar disorder; CESC cis rs9640161 0.789 rs11767409 chr7:150058043 C/T cg10018233 chr7:150070692 REPIN1 0.39 5.59 0.32 5.7e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.58 -8.91 -0.48 8.26e-17 Breast cancer; CESC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.9 0.39 3.79e-11 Bipolar disorder; CESC cis rs7666738 0.791 rs10013680 chr4:99023030 G/C cg17366294 chr4:99064904 C4orf37 0.55 7.57 0.42 6.3e-13 Colonoscopy-negative controls vs population controls; CESC cis rs7223966 1.000 rs11079511 chr17:61858537 C/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.19 -0.3 4.24e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg18876405 chr7:65276391 NA -0.46 -6.23 -0.36 1.86e-9 Aortic root size; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06666157 chr19:4791552 FEM1A 0.52 6.87 0.39 4.68e-11 Systemic lupus erythematosus; CESC cis rs61990749 0.597 rs1008988 chr14:78260795 A/G cg23188588 chr14:78226832 SNW1;C14orf178 0.5 5.17 0.3 4.53e-7 Fibroblast growth factor basic levels; CESC trans rs17685 0.712 rs1637049 chr7:75729975 C/G cg19862616 chr7:65841803 NCRNA00174 0.86 12.59 0.61 8.1e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg25427524 chr10:38739819 LOC399744 -0.67 -9.71 -0.51 2.79e-19 Extrinsic epigenetic age acceleration; CESC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg06873352 chr17:61820015 STRADA 0.73 13.12 0.63 1.2e-30 Prudent dietary pattern; CESC cis rs9611565 0.765 rs132920 chr22:41810170 T/C cg17376030 chr22:41985996 PMM1 -0.59 -6.24 -0.36 1.69e-9 Vitiligo; CESC cis rs748404 0.631 rs11070399 chr15:43646347 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.54 0.46 1.07e-15 Lung cancer; CESC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg07507251 chr3:52567010 NT5DC2 0.43 7.33 0.41 2.73e-12 Bipolar disorder; CESC cis rs11249608 0.548 rs2047354 chr5:178455247 T/C cg21905437 chr5:178450457 ZNF879 0.6 8.74 0.47 2.75e-16 Pubertal anthropometrics; CESC cis rs12618769 0.597 rs3754880 chr2:99132215 G/C cg10123293 chr2:99228465 UNC50 0.41 5.44 0.32 1.24e-7 Bipolar disorder; CESC cis rs9549367 0.865 rs3861721 chr13:113906308 C/T cg18105134 chr13:113819100 PROZ -0.68 -8.25 -0.45 7.53e-15 Platelet distribution width; CESC cis rs8020095 0.571 rs723432 chr14:67379015 A/C cg19548862 chr14:67692701 FAM71D -0.49 -6.07 -0.35 4.46e-9 Depression (quantitative trait); CESC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs1348850 0.872 rs2084233 chr2:178331206 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.89 12.83 0.62 1.21e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg17971929 chr21:40555470 PSMG1 -0.53 -6.8 -0.39 6.76e-11 Menarche (age at onset); CESC cis rs796364 0.774 rs112564437 chr2:201074048 G/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.47 -5.15 -0.3 5.04e-7 Schizophrenia; CESC cis rs6088580 0.505 rs6141503 chr20:33274469 G/A cg24642439 chr20:33292090 TP53INP2 -0.46 -5.48 -0.32 9.84e-8 Glomerular filtration rate (creatinine); CESC cis rs2011503 1.000 rs77427798 chr19:19652982 T/C cg11584989 chr19:19387371 SF4 0.58 6.63 0.38 1.87e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17999743 chr8:38239693 WHSC1L1 0.54 6.13 0.35 3.22e-9 Gut microbiome composition (summer); CESC cis rs6500395 0.926 rs1120275 chr16:48598737 T/G cg04672837 chr16:48644449 N4BP1 0.46 5.54 0.32 7.22e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1570884 0.516 rs7330830 chr13:50167929 T/A cg03651054 chr13:50194643 NA 0.31 5.11 0.3 6.14e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs1215050 0.791 rs1605259 chr4:98799732 T/C cg05340658 chr4:99064831 C4orf37 0.52 6.88 0.39 4.36e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2625529 0.590 rs8023703 chr15:72504059 G/A cg16672083 chr15:72433130 SENP8 0.43 6.03 0.35 5.59e-9 Red blood cell count; CESC cis rs7085104 0.632 rs7097872 chr10:104606636 C/T cg04362960 chr10:104952993 NT5C2 0.5 6.63 0.38 1.83e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs1957429 0.808 rs11158564 chr14:65335082 G/A cg23373153 chr14:65346875 NA 0.89 9.19 0.49 1.19e-17 Pediatric areal bone mineral density (radius); CESC cis rs2857078 0.772 rs2079008 chr17:42322132 C/A cg13607699 chr17:42295918 UBTF -0.76 -10.48 -0.54 1.03e-21 Red cell distribution width;Reticulocyte count; CESC cis rs2425143 1.000 rs8115150 chr20:34397189 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.2 -0.4 6.33e-12 Blood protein levels; CESC cis rs1215050 0.755 rs2952911 chr4:98850666 T/C cg05340658 chr4:99064831 C4orf37 -0.5 -6.59 -0.38 2.32e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs5750830 0.645 rs4821890 chr22:39777523 G/A cg11247378 chr22:39784982 NA -0.5 -7.85 -0.43 1.02e-13 Intelligence (multi-trait analysis); CESC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg17178900 chr1:205818956 PM20D1 0.8 13.21 0.63 5.93e-31 Menarche (age at onset); CESC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg04944784 chr2:26401820 FAM59B -0.63 -7.23 -0.41 5.06e-12 Gut microbiome composition (summer); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg12836313 chr7:156733574 NA 0.44 6.05 0.35 5.04e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7246657 0.943 rs10424574 chr19:37838393 A/G cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs7762018 0.891 rs3749882 chr6:170151766 C/T cg05834625 chr6:170176447 C6orf70 0.65 7.17 0.4 7.57e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04184623 chr2:217277352 SMARCAL1 0.57 6.97 0.39 2.47e-11 Gut microbiome composition (summer); CESC cis rs6502050 0.761 rs62078754 chr17:80058666 C/T cg11859384 chr17:80120422 CCDC57 0.39 5.09 0.3 6.86e-7 Life satisfaction; CESC cis rs9457247 1.000 rs2149091 chr6:167372786 C/T cg25258033 chr6:167368657 RNASET2 -0.41 -6.2 -0.36 2.17e-9 Crohn's disease; CESC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg25072359 chr17:41440525 NA 0.44 6.07 0.35 4.52e-9 Menopause (age at onset); CESC cis rs9362426 0.708 rs9342112 chr6:88092491 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.52 6.31 0.36 1.14e-9 Depressive episodes in bipolar disorder; CESC cis rs7267979 1.000 rs2297497 chr20:25297909 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -17.92 -0.74 1.36e-47 Liver enzyme levels (alkaline phosphatase); CESC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.88e-8 Lung cancer; CESC cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg09165964 chr15:75287851 SCAMP5 0.73 8.62 0.47 6.29e-16 Blood trace element (Zn levels); CESC cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg13628971 chr7:2884303 GNA12 0.4 5.16 0.3 4.91e-7 Height; CESC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg07507251 chr3:52567010 NT5DC2 0.32 5.58 0.32 5.82e-8 Bipolar disorder; CESC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 5.99 0.35 6.86e-9 Personality dimensions; CESC trans rs9354352 0.935 rs9345749 chr6:66699892 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.51 -6.35 -0.36 9.49e-10 Initial pursuit acceleration in psychotic disorders; CESC cis rs1144713 0.743 rs2668273 chr12:32246494 T/C cg01321189 chr12:32259338 BICD1 0.42 5.96 0.34 8.16e-9 Obesity-related traits; CESC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg23048001 chr7:2026167 MAD1L1 0.44 5.54 0.32 7.24e-8 Bipolar disorder and schizophrenia; CESC cis rs2243480 1.000 rs59794892 chr7:65415873 G/A cg18252515 chr7:66147081 NA -1.04 -9.61 -0.51 6.15e-19 Diabetic kidney disease; CESC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 11.7 0.58 8.86e-26 Platelet count; CESC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.94 9.49 0.5 1.42e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20762182 chr15:69727293 KIF23 -0.68 -7.76 -0.43 1.83e-13 Gut microbiome composition (summer); CESC cis rs35110281 0.744 rs230646 chr21:44918788 A/G cg21573476 chr21:45109991 RRP1B -0.38 -5.15 -0.3 5.18e-7 Mean corpuscular volume; CESC cis rs858239 0.600 rs4321896 chr7:23128056 G/A cg23682824 chr7:23144976 KLHL7 0.54 7.34 0.41 2.63e-12 Cerebrospinal fluid biomarker levels; CESC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg04317338 chr11:64019027 PLCB3 0.77 7.82 0.43 1.26e-13 Mean platelet volume; CESC cis rs1267303 0.798 rs1267302 chr1:46990545 G/C cg25110126 chr1:46999211 NA -0.78 -9.2 -0.49 1.09e-17 Monobrow; CESC cis rs60843830 1.000 rs62114505 chr2:242426 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.89 11.99 0.59 9.15e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg24879335 chr3:133465180 TF 0.31 5.13 0.3 5.62e-7 Iron status biomarkers; CESC cis rs7772486 0.686 rs1292336 chr6:145967818 T/C cg23711669 chr6:146136114 FBXO30 -0.89 -13.32 -0.63 2.51e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg10523679 chr1:76189770 ACADM 0.67 6.74 0.38 9.82e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2000999 0.514 rs12928056 chr16:72225574 C/A cg04254540 chr16:71951199 KIAA0174 -0.7 -5.91 -0.34 1.03e-8 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC trans rs2530545 0.851 rs2609234 chr7:34688425 G/A cg14080982 chr15:71736038 THSD4 -0.49 -6.01 -0.35 6.25e-9 IgG glycosylation; CESC cis rs6545883 0.965 rs766447 chr2:61735569 C/T cg15711740 chr2:61764176 XPO1 -0.42 -5.29 -0.31 2.58e-7 Tuberculosis; CESC cis rs12478296 1.000 rs4973685 chr2:243019089 A/C cg06360820 chr2:242988706 NA -0.89 -9.19 -0.49 1.16e-17 Obesity-related traits; CESC cis rs7666738 0.830 rs7696686 chr4:98938445 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC trans rs4596713 0.538 rs10781440 chr9:71762766 A/G cg16512924 chr15:28394682 HERC2 -0.5 -6.32 -0.36 1.11e-9 Headache; CESC cis rs17253792 0.822 rs76201070 chr14:56063604 A/C cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC cis rs698833 0.886 rs2053454 chr2:44550290 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.58 7.2 0.4 6.12e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs6840258 1.000 rs72667753 chr4:87941012 C/T cg08197287 chr4:87952173 AFF1 -0.41 -5.52 -0.32 8.12e-8 Mean corpuscular volume;Basophil percentage of granulocytes; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg07545636 chr2:10262820 RRM2 -0.45 -6.22 -0.36 1.97e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2228479 0.850 rs11641552 chr16:89838700 C/A cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg09359103 chr1:154839909 KCNN3 -0.65 -12.33 -0.6 6.58e-28 Prostate cancer; CESC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg18876405 chr7:65276391 NA 0.53 7.06 0.4 1.42e-11 Aortic root size; CESC cis rs9611519 0.929 rs9611474 chr22:41434858 G/A cg03806693 chr22:41940476 POLR3H -0.57 -5.92 -0.34 1.01e-8 Neuroticism; CESC cis rs7927771 0.542 rs11039336 chr11:47706141 A/G cg20307385 chr11:47447363 PSMC3 -0.57 -7.85 -0.43 1.02e-13 Subjective well-being; CESC cis rs2380220 0.808 rs72922390 chr6:95934317 G/A cg15832292 chr6:96025679 MANEA -0.64 -5.71 -0.33 2.99e-8 Behavioural disinhibition (generation interaction); CESC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg21770322 chr7:97807741 LMTK2 0.56 8.63 0.47 5.86e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs929354 0.742 rs2051877 chr7:157008813 A/T cg05182265 chr7:156933206 UBE3C -0.5 -7.29 -0.41 3.54e-12 Body mass index; CESC cis rs7089973 0.604 rs2181563 chr10:116604344 T/C cg23260525 chr10:116636907 FAM160B1 0.41 7.99 0.44 4.06e-14 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs3785574 0.962 rs2727280 chr17:61918082 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.57 6.75 0.38 9.14e-11 Height; CESC cis rs4481887 1.000 rs7513161 chr1:248453422 A/T cg00666640 chr1:248458726 OR2T12 0.39 6.51 0.37 3.71e-10 Common traits (Other); CESC cis rs652260 0.663 rs580984 chr19:7881030 C/T cg26014689 chr19:7917955 EVI5L -0.4 -5.57 -0.32 6.33e-8 Menarche (age at onset); CESC cis rs909674 0.731 rs6001594 chr22:39837472 C/T cg24399712 chr22:39784796 NA -0.83 -10.9 -0.56 4.11e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg18099408 chr3:52552593 STAB1 -0.34 -5.54 -0.32 7.37e-8 Bipolar disorder; CESC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg14983838 chr19:29218262 NA 0.5 6.16 0.35 2.67e-9 Methadone dose in opioid dependence; CESC cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg00149659 chr3:10157352 C3orf10 1.01 12.53 0.61 1.33e-28 Alzheimer's disease; CESC cis rs7100689 0.577 rs1143694 chr10:82040052 C/T cg09936400 chr10:82049201 MAT1A -0.41 -6.19 -0.36 2.33e-9 Post bronchodilator FEV1; CESC trans rs561341 0.941 rs4795664 chr17:30233467 C/T cg20587970 chr11:113659929 NA -1.09 -13.14 -0.63 1.04e-30 Hip circumference adjusted for BMI; CESC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg24549020 chr5:56110836 MAP3K1 -0.58 -6.28 -0.36 1.37e-9 Initial pursuit acceleration; CESC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg16325326 chr1:53192061 ZYG11B 0.97 16.59 0.71 7.31e-43 Monocyte count; CESC cis rs7903847 0.642 rs7909345 chr10:99150794 T/C cg20016023 chr10:99160130 RRP12 -0.3 -5.1 -0.3 6.33e-7 Granulocyte percentage of myeloid white cells; CESC cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg23711669 chr6:146136114 FBXO30 -1.0 -15.53 -0.69 4.13e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.905 rs1355146 chr6:145781741 A/C cg05347473 chr6:146136440 FBXO30 -0.41 -5.49 -0.32 9.46e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.935 rs399169 chr6:145836353 C/A cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs2228479 0.850 rs17226973 chr16:89825248 T/C cg06558623 chr16:89946397 TCF25 1.17 9.38 0.5 3.19e-18 Skin colour saturation; CESC cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg22875332 chr1:76189707 ACADM -0.55 -6.07 -0.35 4.37e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2425143 1.000 rs17093027 chr20:34319118 A/T cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.31 0.31 2.37e-7 Blood protein levels; CESC cis rs3780486 0.505 rs10217267 chr9:33146528 T/C cg13443165 chr9:33130375 B4GALT1 0.48 7.33 0.41 2.74e-12 IgG glycosylation; CESC cis rs2760061 0.583 rs708123 chr1:228220495 A/G cg02753203 chr1:228287806 NA 0.83 12.88 0.62 8.61e-30 Diastolic blood pressure; CESC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg17427002 chr7:12443146 VWDE -0.56 -5.85 -0.34 1.42e-8 Coronary artery disease; CESC cis rs896854 0.517 rs10112447 chr8:95955701 C/T cg16049864 chr8:95962084 TP53INP1 -0.53 -7.69 -0.43 2.86e-13 Type 2 diabetes; CESC cis rs763014 0.931 rs7192508 chr16:630367 C/T cg07343612 chr16:622815 PIGQ -0.58 -8.47 -0.46 1.72e-15 Height; CESC cis rs897984 0.683 rs8050330 chr16:30824970 C/T cg00531865 chr16:30841666 NA -0.54 -7.66 -0.43 3.46e-13 Dementia with Lewy bodies; CESC trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21659725 chr3:3221576 CRBN -0.82 -13.56 -0.64 3.55e-32 Intelligence (multi-trait analysis); CESC cis rs6121246 0.559 rs6060621 chr20:30261562 G/C cg13852791 chr20:30311386 BCL2L1 0.82 10.64 0.55 3.02e-22 Mean corpuscular hemoglobin; CESC cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1048238 0.506 rs10737911 chr1:16167855 C/T cg21385522 chr1:16154831 NA -0.46 -6.09 -0.35 3.91e-9 Systolic blood pressure; CESC trans rs61931739 0.517 rs1843738 chr12:34056935 C/T cg26384229 chr12:38710491 ALG10B 0.6 8.36 0.46 3.68e-15 Morning vs. evening chronotype; CESC cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg05340658 chr4:99064831 C4orf37 0.75 10.87 0.56 5.36e-23 Colonoscopy-negative controls vs population controls; CESC cis rs2262909 1.000 rs2359821 chr19:22208314 C/T cg11619707 chr19:22235551 ZNF257 -0.35 -5.7 -0.33 3.19e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs67460515 0.892 rs35310734 chr3:160943209 T/G cg03342759 chr3:160939853 NMD3 -0.53 -7.56 -0.42 6.54e-13 Parkinson's disease; CESC cis rs55788414 0.505 rs7190949 chr16:81189583 C/T cg06400318 chr16:81190750 PKD1L2 0.47 6.56 0.37 2.8e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs10088262 0.629 rs7015861 chr8:124795613 C/T cg02993010 chr8:124780839 FAM91A1 -0.67 -8.48 -0.46 1.56e-15 Pancreatic cancer; CESC trans rs877282 1.000 rs71494928 chr10:769134 A/G cg22713356 chr15:30763199 NA 1.22 12.0 0.59 8.77e-27 Uric acid levels; CESC cis rs7520050 0.931 rs11211213 chr1:46342517 G/A cg03146154 chr1:46216737 IPP -0.48 -6.22 -0.36 1.98e-9 Red blood cell count;Reticulocyte count; CESC cis rs2404602 0.536 rs1587381 chr15:76769620 G/A cg26408565 chr15:76604113 ETFA -0.43 -6.4 -0.37 7.01e-10 Blood metabolite levels; CESC cis rs34779708 0.966 rs10827487 chr10:35406878 T/A cg04310649 chr10:35416472 CREM -0.55 -6.77 -0.38 8.07e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 0.545 rs10261710 chr7:65714189 T/A cg11764359 chr7:65958608 NA 0.75 8.29 0.45 5.68e-15 Aortic root size; CESC cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg12386194 chr3:101231763 SENP7 0.57 6.55 0.37 3e-10 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg03452623 chr4:187889614 NA -0.88 -15.91 -0.7 1.82e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs3771570 1.000 rs56363214 chr2:242227157 A/G cg21155796 chr2:242212141 HDLBP 0.62 5.18 0.3 4.34e-7 Prostate cancer; CESC cis rs881375 0.678 rs10739581 chr9:123696871 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.45 6.47 0.37 4.63e-10 Rheumatoid arthritis; CESC cis rs6460942 1.000 rs79659770 chr7:12326371 T/C cg02935154 chr7:12443704 VWDE -0.6 -5.95 -0.34 8.36e-9 Coronary artery disease; CESC cis rs3820068 0.603 rs998032 chr1:15989918 T/C cg18133145 chr1:16060689 PLEKHM2 -0.39 -5.05 -0.3 8.06e-7 Systolic blood pressure; CESC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg24308560 chr3:49941425 MST1R 0.57 7.87 0.44 9.02e-14 Body mass index; CESC trans rs9929218 0.954 rs12599393 chr16:68829021 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -7.99 -0.44 4.18e-14 Colorectal cancer; CESC cis rs12477438 0.559 rs6733285 chr2:99725575 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 12.74 0.62 2.5e-29 Chronic sinus infection; CESC cis rs714031 1.000 rs714031 chr22:40070234 C/T cg21377881 chr22:40064566 CACNA1I 0.33 5.46 0.32 1.09e-7 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11970458 chr16:31213481 PYCARD -0.45 -6.49 -0.37 4.16e-10 Gambling; CESC cis rs911555 0.511 rs2296483 chr14:104029792 G/A cg12935359 chr14:103987150 CKB -0.46 -6.81 -0.39 6.46e-11 Intelligence (multi-trait analysis); CESC cis rs6499255 0.951 rs12232410 chr16:69736851 G/A cg15192750 chr16:69999425 NA 0.47 5.74 0.33 2.62e-8 IgE levels; CESC cis rs2011503 1.000 rs7256028 chr19:19628240 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.45 0.32 1.15e-7 Bipolar disorder; CESC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.34 0.31 2.05e-7 Cognitive function; CESC cis rs11718455 0.960 rs13081767 chr3:44004468 T/C cg08738300 chr3:44038990 NA 0.46 6.07 0.35 4.34e-9 Coronary artery disease; CESC cis rs9388451 0.626 rs1343116 chr6:126069702 C/A cg05901451 chr6:126070800 HEY2 -0.61 -9.27 -0.49 6.65e-18 Brugada syndrome; CESC cis rs10779751 1.000 rs4845859 chr1:11304873 A/G cg08854313 chr1:11322531 MTOR 0.8 10.83 0.55 6.99e-23 Body mass index; CESC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg18876405 chr7:65276391 NA -0.53 -7.22 -0.41 5.6e-12 Aortic root size; CESC cis rs7296418 0.961 rs1790122 chr12:123606739 G/A cg05973401 chr12:123451056 ABCB9 0.55 7.08 0.4 1.29e-11 Platelet count; CESC cis rs7208859 0.623 rs9898084 chr17:29082334 C/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10832963 0.686 rs11024743 chr11:18653712 A/G cg09201001 chr11:18656081 SPTY2D1 0.83 12.37 0.6 4.94e-28 Breast cancer; CESC cis rs6964587 1.000 rs10245095 chr7:91710845 A/G cg01689657 chr7:91764605 CYP51A1 0.28 5.08 0.3 7.2e-7 Breast cancer; CESC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -12.68 -0.61 3.95e-29 Gut microbiome composition (summer); CESC cis rs2637266 0.703 rs11001861 chr10:78473552 A/C cg18941641 chr10:78392320 NA 0.39 7.28 0.41 3.8e-12 Pulmonary function; CESC cis rs4253772 0.744 rs4253760 chr22:46622384 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.51 5.55 0.32 7.01e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7267979 1.000 rs2258135 chr20:25272323 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.62 0.75 4.72e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs807669 0.557 rs712958 chr22:19167409 T/C cg02655711 chr22:19163373 SLC25A1 0.77 11.28 0.57 2.36e-24 Metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02081925 chr5:176931394 DOK3 0.48 6.81 0.39 6.34e-11 Fibrinogen levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03872745 chr12:109125505 CORO1C -0.39 -6.34 -0.36 9.92e-10 Gambling; CESC cis rs3806843 1.000 rs6870764 chr5:140171790 C/T cg26395211 chr5:140044315 WDR55 -0.41 -5.26 -0.31 2.97e-7 Depressive symptoms (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07934232 chr19:36619082 NA 0.61 6.9 0.39 3.91e-11 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.22 0.63 5.56e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg11764359 chr7:65958608 NA -0.78 -11.64 -0.58 1.47e-25 Aortic root size; CESC cis rs7824557 0.593 rs11774673 chr8:11191537 T/C cg21775007 chr8:11205619 TDH 0.55 8.63 0.47 5.8e-16 Retinal vascular caliber; CESC cis rs1256061 0.624 rs1152582 chr14:64692630 G/C cg23250157 chr14:64679961 SYNE2 0.53 7.53 0.42 8.07e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs561341 1.000 rs501312 chr17:30329066 A/G cg27661571 chr11:113659931 NA -0.82 -7.6 -0.42 5.24e-13 Hip circumference adjusted for BMI; CESC cis rs55883249 1.000 rs56372340 chr2:9741536 A/G cg23886495 chr2:9695866 ADAM17 0.61 5.55 0.32 7.08e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs6582630 0.555 rs11504385 chr12:38285085 G/A cg26384229 chr12:38710491 ALG10B -0.45 -5.75 -0.33 2.43e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg23905817 chr15:57884033 GCOM1 0.52 6.37 0.36 8.32e-10 Psoriatic arthritis; CESC cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg11161846 chr1:160990452 F11R -0.44 -6.06 -0.35 4.53e-9 Granulocyte percentage of myeloid white cells; CESC cis rs1005277 0.505 rs10827836 chr10:38215441 A/G cg00409905 chr10:38381863 ZNF37A 0.57 8.02 0.44 3.52e-14 Extrinsic epigenetic age acceleration; CESC cis rs9900062 0.586 rs12600679 chr17:62687327 T/G cg02097616 chr17:62675921 NA 0.46 5.63 0.33 4.56e-8 QT interval; CESC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.34 0.31 2.02e-7 Electroencephalogram traits; CESC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.54 -0.32 7.2e-8 Lung cancer; CESC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.53 -0.32 7.81e-8 Huntington's disease progression; CESC cis rs6460942 0.915 rs2216051 chr7:12304054 G/A cg02935154 chr7:12443704 VWDE -0.4 -5.54 -0.32 7.3e-8 Coronary artery disease; CESC cis rs10492096 1.000 rs12427239 chr12:6590626 C/T cg13857086 chr12:6580257 VAMP1 0.52 5.22 0.31 3.57e-7 Hip geometry; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24722749 chr1:24969476 SRRM1 0.53 6.01 0.35 6.19e-9 Gut microbiome composition (summer); CESC trans rs61931739 0.534 rs11053021 chr12:34111157 C/T cg26384229 chr12:38710491 ALG10B 0.6 8.45 0.46 1.98e-15 Morning vs. evening chronotype; CESC cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg06697600 chr4:7070879 GRPEL1 -0.47 -7.02 -0.4 1.84e-11 Monocyte percentage of white cells; CESC cis rs66530629 0.874 rs6600274 chr1:25162444 T/G cg22509179 chr1:25234806 RUNX3 -0.42 -5.58 -0.32 6.02e-8 Plateletcrit; CESC cis rs7914558 0.966 rs10450373 chr10:104728616 T/C cg08650961 chr10:104748594 CNNM2 0.31 5.06 0.3 7.7300000000000005e-07 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs10927875 0.632 rs4661666 chr1:16162471 C/A cg18973939 chr1:16164122 FLJ37453 0.36 5.5 0.32 9e-8 Dilated cardiomyopathy; CESC cis rs1506636 1.000 rs646753 chr7:123401237 G/T cg03229431 chr7:123269106 ASB15 0.53 6.98 0.39 2.43e-11 Plateletcrit;Platelet count; CESC cis rs992157 0.767 rs2014615 chr2:219171191 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.64 8.75 0.47 2.53e-16 Colorectal cancer; CESC cis rs752010 0.714 rs10789403 chr1:42085869 G/A cg06885757 chr1:42089581 HIVEP3 0.51 8.9 0.48 8.84e-17 Lupus nephritis in systemic lupus erythematosus; CESC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg04756594 chr16:24857601 SLC5A11 -0.45 -5.52 -0.32 8.21e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs7819412 0.549 rs28887839 chr8:11000413 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -6.0 -0.35 6.55e-9 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07223164 chr4:109571402 OSTC -0.53 -6.48 -0.37 4.48e-10 Gut microbiome composition (summer); CESC cis rs2732480 0.517 rs2634676 chr12:48738236 A/G cg24011408 chr12:48396354 COL2A1 0.44 5.99 0.35 6.99e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg02079420 chr8:82753780 SNX16 0.52 7.74 0.43 2.04e-13 Diastolic blood pressure; CESC cis rs10883723 0.962 rs10883726 chr10:104236276 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.34 0.41 2.67e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs8133932 0.654 rs10854474 chr21:47332700 A/G cg14185626 chr21:47401492 COL6A1 0.46 5.12 0.3 5.88e-7 Schizophrenia; CESC cis rs17376456 1.000 rs9968749 chr5:93509559 A/G cg21475434 chr5:93447410 FAM172A 0.86 7.71 0.43 2.49e-13 Diabetic retinopathy; CESC trans rs2727020 0.553 rs10839295 chr11:49527345 A/C cg15704280 chr7:45808275 SEPT13 -0.94 -16.06 -0.7 5.27e-41 Coronary artery disease; CESC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg07090678 chr1:91966139 CDC7 0.39 5.61 0.33 5.02e-8 Breast cancer; CESC trans rs11098499 0.909 rs28571712 chr4:120375980 G/A cg25214090 chr10:38739885 LOC399744 0.71 9.96 0.52 4.62e-20 Corneal astigmatism; CESC cis rs2288912 0.807 rs7251501 chr19:45455706 C/T cg09555818 chr19:45449301 APOC2 0.41 6.54 0.37 3.08e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7599312 0.532 rs16848751 chr2:213389346 A/G cg20637307 chr2:213403960 ERBB4 0.4 5.51 0.32 8.68e-8 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2227631 0.505 rs4729662 chr7:100765559 C/T cg18465962 chr7:100767262 NA 0.49 7.22 0.41 5.67e-12 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg07507251 chr3:52567010 NT5DC2 0.35 5.94 0.34 8.88e-9 Bipolar disorder; CESC cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg14440974 chr22:39074834 NA 0.39 5.29 0.31 2.53e-7 Menopause (age at onset); CESC cis rs8180040 0.701 rs7625067 chr3:47095305 T/C cg27129171 chr3:47204927 SETD2 0.7 10.49 0.54 9.21e-22 Colorectal cancer; CESC cis rs1577917 1.000 rs12199516 chr6:86726221 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.24 -0.36 1.74e-9 Response to antipsychotic treatment; CESC cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 6.99 0.39 2.25e-11 Colorectal cancer; CESC cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.611 rs72783619 chr2:24311607 G/A cg06627628 chr2:24431161 ITSN2 -0.67 -6.48 -0.37 4.54e-10 Lymphocyte counts; CESC cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.48 5.3 0.31 2.39e-7 Osteoporosis; CESC cis rs3213545 0.700 rs2260445 chr12:121468863 C/A cg15155738 chr12:121454335 C12orf43 0.5 6.13 0.35 3.13e-9 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs12220238 1.000 rs10824103 chr10:75949415 A/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.06 0.3 7.92e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg06600287 chr1:53387719 ECHDC2 -0.31 -5.74 -0.33 2.64e-8 Monocyte count; CESC cis rs2980439 0.818 rs2945249 chr8:8094726 G/A cg15556689 chr8:8085844 FLJ10661 0.66 8.26 0.45 6.9e-15 Neuroticism; CESC trans rs35110281 0.774 rs1003280 chr21:44997322 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.55 0.37 2.95e-10 Mean corpuscular volume; CESC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg03709012 chr19:19516395 GATAD2A 1.02 15.58 0.69 2.79e-39 Tonsillectomy; CESC cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg18180107 chr4:99064573 C4orf37 0.42 5.23 0.31 3.42e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 10.49 0.54 9.53e-22 Platelet count; CESC cis rs8077889 1.000 rs4793035 chr17:41887753 C/T cg26893861 chr17:41843967 DUSP3 0.84 9.77 0.51 1.89e-19 Triglycerides; CESC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs11785400 0.928 rs750529 chr8:143744877 G/C cg24634471 chr8:143751801 JRK 0.47 6.25 0.36 1.61e-9 Schizophrenia; CESC trans rs2727020 0.514 rs4980444 chr11:49550764 T/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.08 -0.7 4.42e-41 Coronary artery disease; CESC cis rs478304 0.654 rs11227260 chr11:65461158 G/T cg27068330 chr11:65405492 SIPA1 -0.46 -5.38 -0.31 1.63e-7 Acne (severe); CESC cis rs2742234 0.554 rs1270015 chr10:43698240 G/T cg07801480 chr10:43725741 RASGEF1A -0.42 -5.34 -0.31 2.05e-7 Hirschsprung disease; CESC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg26354017 chr1:205819088 PM20D1 -0.4 -5.2 -0.3 4.07e-7 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg26850624 chr5:429559 AHRR -0.5 -6.67 -0.38 1.52e-10 Cystic fibrosis severity; CESC cis rs17401966 0.931 rs2236678 chr1:10471789 A/T cg15208524 chr1:10270712 KIF1B 0.41 5.12 0.3 5.94e-7 Hepatocellular carcinoma; CESC cis rs9911578 1.000 rs12947785 chr17:57045160 A/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.96 -0.39 2.66e-11 Intelligence (multi-trait analysis); CESC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg19318889 chr4:1322082 MAEA -0.46 -6.04 -0.35 5.19e-9 Obesity-related traits; CESC cis rs9549367 0.707 rs9549353 chr13:113843427 G/A cg00898013 chr13:113819073 PROZ -0.56 -7.55 -0.42 7.02e-13 Platelet distribution width; CESC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg03806693 chr22:41940476 POLR3H -1.24 -16.8 -0.72 1.25e-43 Vitiligo; CESC cis rs367615 0.704 rs72802966 chr5:108846754 T/G cg17395555 chr5:108820864 NA 0.61 10.98 0.56 2.33e-23 Colorectal cancer (SNP x SNP interaction); CESC cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg12193833 chr17:30244370 NA -0.74 -6.71 -0.38 1.19e-10 Hip circumference adjusted for BMI; CESC cis rs36051895 0.632 rs10815164 chr9:5131312 T/A cg02405213 chr9:5042618 JAK2 -0.49 -5.86 -0.34 1.35e-8 Pediatric autoimmune diseases; CESC cis rs8051149 0.793 rs12445334 chr16:87871213 G/A cg01829163 chr16:87871160 SLC7A5 -0.47 -5.48 -0.32 1e-7 Blood metabolite levels; CESC cis rs1005277 0.522 rs9417256 chr10:37976990 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -9.67 -0.51 3.87e-19 Extrinsic epigenetic age acceleration; CESC cis rs2933343 0.729 rs1680781 chr3:128612830 C/A cg25356066 chr3:128598488 ACAD9 0.63 8.61 0.47 6.83e-16 IgG glycosylation; CESC cis rs2299587 0.554 rs11778309 chr8:17747433 T/C cg08627089 chr8:17753878 FGL1 -0.41 -5.87 -0.34 1.33e-8 Economic and political preferences; CESC cis rs9788682 0.706 rs924840 chr15:78731808 A/T cg24631222 chr15:78858424 CHRNA5 0.64 7.58 0.42 5.73e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7937682 0.847 rs500163 chr11:111462649 T/G cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC cis rs8133932 0.654 rs407651 chr21:47350587 C/T cg14185626 chr21:47401492 COL6A1 -0.47 -5.34 -0.31 2.04e-7 Schizophrenia; CESC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs727505 0.721 rs17327715 chr7:124760611 G/C cg23710748 chr7:124431027 NA -0.37 -6.13 -0.35 3.2e-9 Lewy body disease; CESC cis rs7666738 0.761 rs1456210 chr4:98645932 T/G cg05340658 chr4:99064831 C4orf37 0.73 10.65 0.55 2.7e-22 Colonoscopy-negative controls vs population controls; CESC cis rs6088580 0.634 rs4142007 chr20:32990050 G/T cg24642439 chr20:33292090 TP53INP2 -0.52 -6.9 -0.39 3.82e-11 Glomerular filtration rate (creatinine); CESC cis rs761746 0.882 rs5998032 chr22:31928890 T/G cg25791279 chr22:32026902 PISD -0.54 -6.15 -0.35 2.79e-9 Intelligence; CESC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg08888203 chr3:10149979 C3orf24 0.55 7.2 0.4 6.16e-12 Alzheimer's disease; CESC cis rs9303401 0.614 rs62084387 chr17:57148027 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.98 11.04 0.56 1.43e-23 Cognitive test performance; CESC cis rs2439831 0.867 rs2251844 chr15:43836478 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.79 8.5 0.46 1.39e-15 Lung cancer in ever smokers; CESC cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2294693 0.898 rs6458195 chr6:40972498 A/T cg14418226 chr6:40996092 UNC5CL -0.47 -5.75 -0.33 2.42e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs11155671 0.530 rs7758020 chr6:150208111 T/C cg09699651 chr6:150184138 LRP11 0.56 7.79 0.43 1.56e-13 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17748287 chr17:36762518 SRCIN1 0.64 7.2 0.4 6.14e-12 Gut microbiome composition (summer); CESC cis rs854765 0.693 rs12936037 chr17:17777245 A/G cg16928487 chr17:17741425 SREBF1 0.61 11.07 0.56 1.2e-23 Total body bone mineral density; CESC cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.65 -8.78 -0.47 2.08e-16 Hip circumference adjusted for BMI; CESC cis rs7772486 0.686 rs9386131 chr6:146121608 G/A cg23711669 chr6:146136114 FBXO30 0.87 13.02 0.62 2.64e-30 Lobe attachment (rater-scored or self-reported); CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg04407233 chr1:10042538 NMNAT1 0.49 6.19 0.36 2.29e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC trans rs1728785 1.000 rs1645923 chr16:68581051 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs748404 0.697 rs554001 chr15:43551919 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.61 8.12 0.45 1.76e-14 Lung cancer; CESC cis rs3617 0.559 rs11915546 chr3:52866845 A/C cg11645453 chr3:52864694 ITIH4 -0.26 -5.18 -0.3 4.48e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs959260 0.925 rs7207506 chr17:73409410 T/C cg12999837 chr17:73267436 MIF4GD -0.47 -5.48 -0.32 9.95e-8 Systemic lupus erythematosus; CESC cis rs9303401 0.659 rs35797125 chr17:56736547 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.04 13.0 0.62 3.27e-30 Cognitive test performance; CESC cis rs1801251 0.778 rs2250654 chr2:233752376 A/T cg08000102 chr2:233561755 GIGYF2 -0.57 -7.79 -0.43 1.52e-13 Coronary artery disease; CESC cis rs7937682 0.824 rs577044 chr11:111490420 G/T cg22437258 chr11:111473054 SIK2 0.72 9.81 0.52 1.37e-19 Primary sclerosing cholangitis; CESC cis rs7107174 1.000 rs2510055 chr11:77961912 C/T cg02023728 chr11:77925099 USP35 0.51 6.76 0.38 8.54e-11 Testicular germ cell tumor; CESC cis rs11405769 1 rs11405769 chr2:63658293 A/AT cg17519650 chr2:63277830 OTX1 -0.47 -5.25 -0.31 3.09e-7 Childhood ear infection; CESC cis rs10088262 0.629 rs12541177 chr8:124800273 G/T cg20713898 chr8:124780851 FAM91A1 -0.67 -9.11 -0.49 2.02e-17 Pancreatic cancer; CESC cis rs2228479 0.557 rs11648881 chr16:89862434 T/C cg00800038 chr16:89945340 TCF25 -0.9 -7.39 -0.41 1.98e-12 Skin colour saturation; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg16189954 chr22:29138267 HSCB;CHEK2 -0.45 -6.02 -0.35 5.87e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24368588 chr20:61903974 ARFGAP1 0.61 7.39 0.41 1.9e-12 Gut microbiome composition (summer); CESC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg22535103 chr8:58192502 C8orf71 -0.67 -7.23 -0.41 5.31e-12 Developmental language disorder (linguistic errors); CESC cis rs6582630 0.519 rs11495724 chr12:38337507 T/C cg13010199 chr12:38710504 ALG10B 0.47 5.92 0.34 1.01e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs2073300 0.609 rs6137914 chr20:23358364 C/T cg12062639 chr20:23401060 NAPB 1.08 8.67 0.47 4.32e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs13130787 0.567 rs1438382 chr4:94907750 A/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -5.64 -0.33 4.3e-8 Colorectal cancer; CESC cis rs1348850 0.874 rs1348848 chr2:178358233 A/C cg23306229 chr2:178417860 TTC30B -0.65 -8.33 -0.46 4.51e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs7124681 0.584 rs1471712 chr11:47912150 G/A cg18512352 chr11:47633146 NA -0.4 -6.34 -0.36 9.97e-10 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs66573146 0.572 rs66734745 chr4:6948765 T/C cg26116260 chr4:7069785 GRPEL1 -0.79 -5.25 -0.31 3.06e-7 Granulocyte percentage of myeloid white cells; CESC cis rs4803468 1.000 rs4674 chr19:41930396 A/G cg08639244 chr19:41945921 ATP5SL -0.42 -5.07 -0.3 7.34e-7 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04742505 chr7:72936528 BAZ1B -0.43 -6.18 -0.35 2.36e-9 Gambling; CESC cis rs748404 0.631 rs2467745 chr15:43722742 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.3 0.45 5.47e-15 Lung cancer; CESC cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.05 10.33 0.54 2.97e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9287719 0.967 rs963831 chr2:10745184 T/C cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC cis rs926938 0.618 rs6693491 chr1:115371061 A/G cg12756093 chr1:115239321 AMPD1 -0.45 -6.12 -0.35 3.44e-9 Autism; CESC cis rs7116495 0.609 rs73543643 chr11:71835596 C/T cg07596299 chr11:71824057 C11orf51 0.79 5.03 0.3 9.07e-7 Severe influenza A (H1N1) infection; CESC trans rs11098499 0.775 rs10029303 chr4:120286755 T/A cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs16854884 0.632 rs4446205 chr3:143682607 A/G cg06585982 chr3:143692056 C3orf58 0.48 5.92 0.34 1.01e-8 Economic and political preferences (feminism/equality); CESC cis rs3820928 0.874 rs3769646 chr2:227896330 C/T cg11843606 chr2:227700838 RHBDD1 -0.49 -6.47 -0.37 4.59e-10 Pulmonary function; CESC cis rs12477438 0.798 rs7606635 chr2:99644782 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs7647973 0.566 rs57630346 chr3:49086215 T/C cg06212747 chr3:49208901 KLHDC8B 0.49 5.47 0.32 1.02e-7 Menarche (age at onset); CESC cis rs55728055 0.661 rs58365021 chr22:32060838 G/C cg01338084 chr22:32026380 PISD 1.26 8.36 0.46 3.6e-15 Age-related hearing impairment; CESC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.06 0.3 7.83e-7 Bipolar disorder; CESC cis rs7904368 0.806 rs1130684 chr10:16859335 C/G cg23933602 chr10:16859644 RSU1 0.74 7.53 0.42 8.2e-13 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs10851478 0.872 rs35698479 chr15:49797119 A/G cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg18099408 chr3:52552593 STAB1 -0.34 -6.21 -0.36 2.06e-9 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.16.692127F chr16:22223399 EEF2K -0.64 -7.66 -0.43 3.49e-13 Gut microbiome composition (summer); CESC cis rs10979 0.965 rs7754452 chr6:143889028 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs13385 0.769 rs4913072 chr5:139608353 T/C cg26211634 chr5:139558579 C5orf32 0.47 5.16 0.3 4.78e-7 Atrial fibrillation; CESC cis rs2658782 0.789 rs2658773 chr11:93126914 A/G cg15737290 chr11:93063684 CCDC67 0.49 6.14 0.35 3.01e-9 Pulmonary function decline; CESC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg12373951 chr3:133503437 NA 0.44 6.42 0.37 6.42e-10 Iron status biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14373579 chr9:133455264 LOC100272217;FUBP3 0.58 6.65 0.38 1.64e-10 Gut microbiome composition (summer); CESC cis rs4803468 0.935 rs13346603 chr19:41945837 T/A cg09537434 chr19:41945824 ATP5SL 1.12 21.49 0.8 5.38e-60 Height; CESC cis rs34172651 0.917 rs7202252 chr16:24741686 T/C cg06028605 chr16:24865363 SLC5A11 -0.42 -6.3 -0.36 1.23e-9 Intelligence (multi-trait analysis); CESC cis rs6063312 1.000 rs11699576 chr20:47349878 A/C cg18078177 chr20:47281410 PREX1 0.58 5.71 0.33 3.07e-8 Tonometry; CESC cis rs72781680 1.000 rs72781653 chr2:24215633 T/C cg20701182 chr2:24300061 SF3B14 0.66 5.84 0.34 1.56e-8 Lymphocyte counts; CESC cis rs4588572 0.601 rs6867673 chr5:77779125 A/G cg11547950 chr5:77652471 NA -0.48 -6.07 -0.35 4.39e-9 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07549551 chr6:158487608 SYNJ2 -0.59 -6.76 -0.38 8.99e-11 Gut microbiome composition (summer); CESC cis rs11098499 0.954 rs10006525 chr4:120408931 T/G cg09160332 chr4:120329925 NA -0.38 -5.06 -0.3 7.89e-7 Corneal astigmatism; CESC cis rs6736093 0.966 rs11674883 chr2:112713069 C/T cg12686935 chr2:112915763 FBLN7 0.43 5.44 0.32 1.2e-7 Coronary artery disease; CESC cis rs36051895 0.594 rs10115464 chr9:5144268 C/T cg02405213 chr9:5042618 JAK2 -0.51 -6.46 -0.37 5.04e-10 Pediatric autoimmune diseases; CESC trans rs629535 0.814 rs652483 chr8:70055083 G/A cg21567404 chr3:27674614 NA 0.91 10.65 0.55 2.9e-22 Dupuytren's disease; CESC cis rs7998202 0.667 rs99126 chr13:113359336 C/G cg02820901 chr13:113351484 ATP11A -0.65 -5.73 -0.33 2.74e-8 Glycated hemoglobin levels; CESC cis rs9300255 0.544 rs1716174 chr12:123660717 T/C cg00376283 chr12:123451042 ABCB9 0.61 6.2 0.36 2.2e-9 Neutrophil percentage of white cells; CESC cis rs1665050 0.842 rs1665049 chr15:59290652 G/A cg05156742 chr15:59063176 FAM63B -0.45 -5.2 -0.3 4.05e-7 Atopic dermatitis; CESC cis rs9399137 0.507 rs11753673 chr6:135316476 T/C cg24558204 chr6:135376177 HBS1L 0.72 10.08 0.53 1.92e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs66573146 0.831 rs1048009 chr4:6988677 G/A cg00086871 chr4:6988644 TBC1D14 1.21 8.92 0.48 7.85e-17 Granulocyte percentage of myeloid white cells; CESC cis rs11997175 0.574 rs4446694 chr8:33654978 A/G ch.8.33884649F chr8:33765107 NA 0.66 8.38 0.46 3.14e-15 Body mass index; CESC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg07701084 chr6:150067640 NUP43 0.42 5.74 0.33 2.61e-8 Lung cancer; CESC cis rs7917772 0.582 rs10748826 chr10:104354804 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.63 0.33 4.48e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1152591 0.562 rs1262242 chr14:64653869 C/T cg23250157 chr14:64679961 SYNE2 0.4 5.71 0.33 2.97e-8 Atrial fibrillation; CESC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg00149659 chr3:10157352 C3orf10 0.71 8.56 0.47 9.48e-16 Alzheimer's disease; CESC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg05234568 chr11:5960015 NA -0.65 -8.75 -0.47 2.53e-16 DNA methylation (variation); CESC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg24060327 chr5:131705240 SLC22A5 0.74 10.22 0.53 6.96e-21 Breast cancer; CESC cis rs6502050 0.761 rs12150321 chr17:80061558 T/C cg11859384 chr17:80120422 CCDC57 0.38 5.1 0.3 6.51e-7 Life satisfaction; CESC cis rs6088590 1.000 rs910870 chr20:33292893 T/C cg24642439 chr20:33292090 TP53INP2 0.77 10.33 0.54 2.96e-21 Coronary artery disease; CESC cis rs17209837 0.607 rs2109505 chr7:87079406 T/A cg00919237 chr7:87102261 ABCB4 -0.53 -6.76 -0.38 8.95e-11 Gallbladder cancer; CESC trans rs9929218 1.000 rs11865026 chr16:68774283 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -9.86 -0.52 9.59e-20 Colorectal cancer; CESC cis rs2228479 0.850 rs62056069 chr16:89912000 C/T cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg18904891 chr8:8559673 CLDN23 0.66 7.63 0.42 4.23e-13 Obesity-related traits; CESC cis rs2904967 0.636 rs514076 chr11:64990041 G/C cg23743554 chr11:65321226 LTBP3 -0.42 -5.36 -0.31 1.79e-7 Mean corpuscular volume; CESC cis rs3091242 0.933 rs35530120 chr1:25785451 A/G cg12412775 chr1:25698385 RHCE 0.29 5.19 0.3 4.23e-7 Erythrocyte sedimentation rate; CESC trans rs9354308 0.866 rs2814095 chr6:66535706 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 6.67 0.38 1.5e-10 Metabolite levels; CESC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg06873352 chr17:61820015 STRADA 0.72 12.76 0.62 2.21e-29 Prudent dietary pattern; CESC cis rs3126085 0.877 rs7535536 chr1:152193544 A/G cg26876637 chr1:152193138 HRNR 0.47 5.43 0.32 1.28e-7 Atopic dermatitis; CESC cis rs858239 0.600 rs1115941 chr7:23137188 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.72 0.43 2.44e-13 Cerebrospinal fluid biomarker levels; CESC cis rs2204008 0.683 rs12370288 chr12:38127740 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.55 0.54 5.91e-22 Bladder cancer; CESC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs4561483 0.556 rs11570136 chr16:12058832 T/A cg08843971 chr16:11963173 GSPT1 -0.43 -5.72 -0.33 2.87e-8 Testicular germ cell tumor; CESC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg22800045 chr5:56110881 MAP3K1 0.85 10.2 0.53 8.13e-21 Initial pursuit acceleration; CESC cis rs9733 0.744 rs12758227 chr1:150844583 C/A cg13175981 chr1:150552382 MCL1 0.5 6.82 0.39 5.97e-11 Tonsillectomy; CESC cis rs8020095 0.528 rs6573760 chr14:67677375 G/T cg19548862 chr14:67692701 FAM71D -0.47 -5.68 -0.33 3.48e-8 Depression (quantitative trait); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16196077 chr10:64028521 RTKN2 0.44 6.13 0.35 3.25e-9 Asthma; CESC cis rs1003719 0.788 rs2835589 chr21:38463342 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs863345 0.565 rs10908671 chr1:158502160 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs12136530 0.774 rs12140338 chr1:19766430 C/G cg01832549 chr1:19774989 CAPZB -0.47 -6.51 -0.37 3.82e-10 Lead levels in blood; CESC cis rs9300255 0.770 rs28683528 chr12:123845351 C/T cg00376283 chr12:123451042 ABCB9 -0.58 -6.75 -0.38 9.12e-11 Neutrophil percentage of white cells; CESC cis rs1799949 0.965 rs4793234 chr17:41436183 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.55 0.32 6.85e-8 Menopause (age at onset); CESC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg18252515 chr7:66147081 NA -0.46 -6.05 -0.35 5e-9 Aortic root size; CESC cis rs116095464 0.558 rs10055354 chr5:243794 G/A cg22857025 chr5:266934 NA -1.27 -18.37 -0.75 3.49e-49 Breast cancer; CESC trans rs61931739 0.500 rs11053282 chr12:34561151 T/C cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC cis rs10129255 0.957 rs10141009 chr14:107184934 A/G cg07958169 chr14:107095056 NA -0.42 -5.87 -0.34 1.28e-8 Kawasaki disease; CESC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg18240062 chr17:79603768 NPLOC4 -0.72 -10.27 -0.53 4.71e-21 Eye color traits; CESC cis rs17376456 0.877 rs13165147 chr5:93422214 G/A cg21475434 chr5:93447410 FAM172A 0.83 7.47 0.42 1.17e-12 Diabetic retinopathy; CESC cis rs10465746 0.780 rs12139191 chr1:84387871 A/C cg10977910 chr1:84465055 TTLL7 0.5 6.8 0.39 6.77e-11 Obesity-related traits; CESC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg07701084 chr6:150067640 NUP43 0.43 5.85 0.34 1.45e-8 Lung cancer; CESC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs1568889 0.838 rs7952717 chr11:28261658 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.85 0.65 3.36e-33 Bipolar disorder; CESC cis rs60843830 1.000 rs62114544 chr2:269679 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.88 11.83 0.59 3.33e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9815354 0.812 rs17215183 chr3:41812334 T/C cg03022575 chr3:42003672 ULK4 0.7 6.14 0.35 2.98e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.11 0.49 2.03e-17 Tonsillectomy; CESC cis rs10479542 0.503 rs12719865 chr5:178993566 C/T cg21226059 chr5:178986404 RUFY1 0.52 7.8 0.43 1.4e-13 Lung cancer; CESC trans rs1973993 0.691 rs1980683 chr1:96890379 A/G cg10631902 chr5:14652156 NA 0.59 8.95 0.48 6.56e-17 Weight; CESC cis rs7208859 0.614 rs28758251 chr17:29223312 A/T cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs25645 0.830 rs4072639 chr17:38189049 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.61 8.67 0.47 4.48e-16 Myeloid white cell count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23286353 chr2:97523832 ANKRD39 -0.46 -6.1 -0.35 3.83e-9 Ulcerative colitis; CESC cis rs12893668 0.581 rs34843146 chr14:104079864 G/A cg08213375 chr14:104286397 PPP1R13B 0.33 5.16 0.3 4.79e-7 Reticulocyte count; CESC cis rs2760061 0.569 rs621631 chr1:228114728 A/G cg02753203 chr1:228287806 NA -0.5 -7.24 -0.41 4.83e-12 Diastolic blood pressure; CESC cis rs9309473 0.519 rs2421667 chr2:73832459 T/C cg20560298 chr2:73613845 ALMS1 0.52 7.31 0.41 3.18e-12 Metabolite levels; CESC cis rs12449964 0.524 rs897457 chr17:17572987 A/T cg04398451 chr17:18023971 MYO15A 0.37 5.05 0.3 8.13e-7 Coronary artery disease or ischemic stroke; CESC cis rs3749237 0.595 rs3870338 chr3:49557051 A/G cg06212747 chr3:49208901 KLHDC8B 0.47 6.44 0.37 5.58e-10 Resting heart rate; CESC trans rs12310956 0.532 rs7979535 chr12:33947450 A/C cg26384229 chr12:38710491 ALG10B -0.58 -8.08 -0.44 2.32e-14 Morning vs. evening chronotype; CESC cis rs67311347 0.956 rs11714871 chr3:40428938 T/G cg24209194 chr3:40518798 ZNF619 0.47 6.0 0.35 6.55e-9 Renal cell carcinoma; CESC trans rs877282 0.853 rs11595510 chr10:756757 C/G cg22713356 chr15:30763199 NA 0.91 8.68 0.47 4.21e-16 Uric acid levels; CESC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg23590916 chr17:43697445 MGC57346 0.62 6.23 0.36 1.87e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs75804782 0.521 rs72993065 chr2:239409001 C/T cg18131467 chr2:239335373 ASB1 -0.7 -5.49 -0.32 9.55e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs15676 0.947 rs2759009 chr9:131599008 C/T cg00228799 chr9:131580591 ENDOG 0.45 5.56 0.32 6.67e-8 Blood metabolite levels; CESC cis rs2797160 0.967 rs28629380 chr6:126004197 A/G cg05901451 chr6:126070800 HEY2 -0.45 -6.47 -0.37 4.83e-10 Endometrial cancer; CESC cis rs2380220 0.574 rs9374322 chr6:95998994 G/A cg23517279 chr6:96025343 MANEA 0.54 5.8 0.34 1.85e-8 Behavioural disinhibition (generation interaction); CESC cis rs7666738 0.715 rs61114099 chr4:98931270 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4555082 0.718 rs2816619 chr14:105732551 G/C cg27165867 chr14:105738592 BRF1 -0.53 -5.68 -0.33 3.55e-8 Mean platelet volume;Platelet distribution width; CESC cis rs11642862 0.901 rs112190455 chr16:30971437 C/T cg02466173 chr16:30829666 NA -0.57 -5.21 -0.3 3.81e-7 Tonsillectomy; CESC cis rs36051895 0.659 rs3780366 chr9:5068596 T/C cg02405213 chr9:5042618 JAK2 -0.5 -6.18 -0.36 2.37e-9 Pediatric autoimmune diseases; CESC cis rs3820068 0.608 rs11544523 chr1:15904318 C/T cg17385448 chr1:15911702 AGMAT 0.39 5.96 0.34 8.2e-9 Systolic blood pressure; CESC cis rs34779708 0.931 rs4934710 chr10:35350416 T/C cg03585969 chr10:35415529 CREM 0.75 9.67 0.51 3.92e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs2108622 0.668 rs62106153 chr19:15978507 C/T cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs2280018 0.526 rs2941257 chr16:15166445 T/C cg27102117 chr16:15229624 NA 0.54 8.13 0.45 1.7e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7927592 0.731 rs2156463 chr11:68386311 T/C cg01657329 chr11:68192670 LRP5 -0.47 -6.1 -0.35 3.65e-9 Total body bone mineral density; CESC cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg19052272 chr2:3704530 ALLC -0.47 -5.73 -0.33 2.72e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs17826219 0.706 rs609472 chr17:28951427 T/C cg17105886 chr17:28927953 LRRC37B2 0.64 5.65 0.33 4.15e-8 Body mass index; CESC cis rs9814567 1.000 rs4572812 chr3:134291177 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.1 0.35 3.71e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7666738 0.546 rs7699578 chr4:98838893 T/C cg05340658 chr4:99064831 C4orf37 0.51 5.21 0.3 3.79e-7 Colonoscopy-negative controls vs population controls; CESC cis rs17125944 0.505 rs3783447 chr14:53191647 G/A cg13660082 chr14:53194042 PSMC6 -0.64 -5.73 -0.33 2.66e-8 Alzheimer's disease (late onset); CESC cis rs763014 0.898 rs8060585 chr16:635794 C/G cg00908189 chr16:619842 PIGQ 0.65 9.02 0.48 4.04e-17 Height; CESC cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg12193833 chr17:30244370 NA -0.75 -6.92 -0.39 3.36e-11 Hip circumference adjusted for BMI; CESC cis rs12586317 0.547 rs10142667 chr14:35445090 A/G cg16230307 chr14:35515116 FAM177A1 0.9 10.17 0.53 9.99e-21 Psoriasis; CESC cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC trans rs10510776 0.875 rs11710973 chr3:55217512 C/T cg21860029 chr14:82000536 SEL1L 0.62 6.18 0.35 2.44e-9 Cancer; CESC cis rs56104184 0.725 rs1466896 chr19:49385253 C/G cg15549821 chr19:49342101 PLEKHA4 -0.61 -6.24 -0.36 1.72e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg03609598 chr5:56110824 MAP3K1 0.48 5.4 0.31 1.5e-7 Initial pursuit acceleration; CESC cis rs17407555 0.779 rs6851524 chr4:10155041 C/A cg00071950 chr4:10020882 SLC2A9 -0.55 -5.46 -0.32 1.12e-7 Schizophrenia (age at onset); CESC cis rs2120019 0.638 rs12050628 chr15:75333494 G/A cg00629941 chr15:75287862 SCAMP5 0.54 6.42 0.37 6.39e-10 Blood trace element (Zn levels); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02957340 chr14:100070899 CCDC85C -0.5 -6.2 -0.36 2.1e-9 Ulcerative colitis; CESC cis rs4906332 1.000 rs17617307 chr14:103904965 C/G cg09975044 chr14:104007538 NA 0.47 6.53 0.37 3.32e-10 Coronary artery disease; CESC cis rs10088262 0.629 rs9918907 chr8:124816862 A/G cg15047889 chr8:124780837 FAM91A1 -0.49 -6.11 -0.35 3.62e-9 Pancreatic cancer; CESC cis rs2204008 0.560 rs4129033 chr12:38301897 A/T cg26384229 chr12:38710491 ALG10B -0.44 -5.7 -0.33 3.17e-8 Bladder cancer; CESC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg10691866 chr7:65817282 TPST1 -0.34 -5.61 -0.33 5.14e-8 Aortic root size; CESC cis rs1843834 0.505 rs2140508 chr2:225355839 G/T cg12698349 chr2:225449008 CUL3 0.62 8.74 0.47 2.75e-16 IgE levels in asthmatics (D.p. specific); CESC cis rs2549003 1.000 rs2549007 chr5:131826875 T/C cg00255919 chr5:131827918 IRF1 -0.58 -10.12 -0.53 1.41e-20 Asthma (sex interaction); CESC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.71 0.43 2.57e-13 Prudent dietary pattern; CESC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg04944784 chr2:26401820 FAM59B -0.8 -9.34 -0.5 4.19e-18 Gut microbiome composition (summer); CESC cis rs11098499 0.779 rs7674500 chr4:120303593 C/T cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs1707322 1.000 rs7547284 chr1:46319565 C/G cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs60154123 0.772 rs701944 chr1:210417098 G/A cg21951975 chr1:209979733 IRF6 0.5 6.09 0.35 3.87e-9 Coronary artery disease; CESC cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.75 0.47 2.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg02297831 chr4:17616191 MED28 0.51 6.26 0.36 1.5e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9303280 0.806 rs4795399 chr17:38061439 T/C cg19468946 chr17:37922297 IKZF3 -0.39 -5.2 -0.3 4.07e-7 Self-reported allergy; CESC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg17971929 chr21:40555470 PSMG1 1.04 15.91 0.7 1.8e-40 Cognitive function; CESC cis rs6952809 0.532 rs10272548 chr7:2439467 G/A cg23289794 chr7:2394357 EIF3B -0.79 -7.29 -0.41 3.64e-12 Multiple sclerosis; CESC cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg19077165 chr18:44547161 KATNAL2 -0.53 -7.61 -0.42 4.89e-13 Personality dimensions; CESC trans rs9467711 0.606 rs9393713 chr6:26373678 C/T cg06606381 chr12:133084897 FBRSL1 -0.73 -6.91 -0.39 3.57e-11 Autism spectrum disorder or schizophrenia; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg18538332 chr22:24372958 LOC391322 -0.7 -9.9 -0.52 7.45e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg14829155 chr15:31115871 NA -0.77 -10.1 -0.53 1.69e-20 Huntington's disease progression; CESC cis rs4803468 1.000 rs2241710 chr19:41912092 G/C cg09537434 chr19:41945824 ATP5SL -1.09 -19.11 -0.76 9.32e-52 Height; CESC cis rs7089973 0.523 rs7099590 chr10:116749706 G/A cg23260525 chr10:116636907 FAM160B1 0.3 5.15 0.3 5.12e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7020830 0.931 rs13288178 chr9:37107799 A/G cg14294708 chr9:37120828 ZCCHC7 1.27 24.82 0.84 4.28e-71 Schizophrenia; CESC cis rs61935443 0.720 rs10859783 chr12:95285339 A/G cg21533806 chr12:95267307 NA 0.55 6.71 0.38 1.17e-10 Schizophrenia; CESC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg08470875 chr2:26401718 FAM59B 0.65 6.79 0.38 7.44e-11 Gut microbiome composition (summer); CESC cis rs71403859 0.803 rs8063455 chr16:71599977 G/A cg08717414 chr16:71523259 ZNF19 -0.81 -7.08 -0.4 1.26e-11 Post bronchodilator FEV1; CESC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg18350739 chr11:68623251 NA -0.43 -6.72 -0.38 1.09e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9467711 0.606 rs68072215 chr6:26377927 T/C cg14345882 chr6:26364793 BTN3A2 0.64 6.38 0.36 7.8e-10 Autism spectrum disorder or schizophrenia; CESC cis rs2880765 0.835 rs7162502 chr15:86044473 G/T cg10818794 chr15:86012489 AKAP13 -0.34 -5.22 -0.31 3.68e-7 Coronary artery disease; CESC cis rs1401999 1.000 rs2313217 chr3:183635997 A/G cg01324343 chr3:183735012 ABCC5 0.63 13.45 0.64 8.71e-32 Anterior chamber depth; CESC trans rs10506458 0.834 rs55966529 chr12:63384114 A/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.3 -17.35 -0.73 1.38e-45 Hemostatic factors and hematological phenotypes; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg19639873 chr12:49716966 TROAP 0.47 6.03 0.35 5.58e-9 Obesity-related traits; CESC cis rs7918232 0.505 rs788221 chr10:27442247 G/C cg14240646 chr10:27532245 ACBD5 0.73 5.6 0.33 5.24e-8 Breast cancer; CESC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg17427002 chr7:12443146 VWDE -0.48 -5.33 -0.31 2.06e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25936770 chr7:122321411 CADPS2 -0.72 -8.75 -0.47 2.48e-16 Gut microbiome composition (summer); CESC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg14703610 chr5:56206110 C5orf35 -0.4 -5.1 -0.3 6.52e-7 Initial pursuit acceleration; CESC cis rs4253772 0.591 rs7291444 chr22:46656246 T/G cg24881330 chr22:46731750 TRMU 0.85 9.61 0.51 5.92e-19 LDL cholesterol;Cholesterol, total; CESC cis rs2439831 0.681 rs956391 chr15:43617493 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.93 -13.41 -0.64 1.24e-31 Lung cancer in ever smokers; CESC cis rs7714584 1.000 rs11951694 chr5:150254338 G/A cg22134413 chr5:150180641 NA 0.51 5.92 0.34 9.88e-9 Crohn's disease; CESC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01014486 chr7:2598706 IQCE 0.6 7.24 0.41 4.9e-12 Gut microbiome composition (summer); CESC cis rs2235544 0.565 rs634532 chr1:54468947 G/C cg25741118 chr1:54482237 LDLRAD1 0.24 5.77 0.33 2.2e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs72781680 0.898 rs6712175 chr2:24023431 T/G cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs3733585 0.673 rs7376505 chr4:9952744 C/A cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.44e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4561483 0.583 rs11075030 chr16:11976414 C/A cg08843971 chr16:11963173 GSPT1 0.47 6.57 0.37 2.59e-10 Testicular germ cell tumor; CESC cis rs1559088 0.948 rs3760893 chr19:33597930 C/A cg27124370 chr19:33622961 WDR88 0.46 6.11 0.35 3.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs113835537 0.529 rs3816492 chr11:66297363 C/T cg22134325 chr11:66188745 NPAS4 0.45 6.75 0.38 9.12e-11 Airway imaging phenotypes; CESC cis rs2933343 0.700 rs1683787 chr3:128627021 C/T cg24203234 chr3:128598194 ACAD9 -0.41 -5.64 -0.33 4.39e-8 IgG glycosylation; CESC cis rs2637266 1.000 rs7896379 chr10:78366247 C/T cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg09359103 chr1:154839909 KCNN3 -0.65 -12.19 -0.6 1.91e-27 Prostate cancer; CESC cis rs7044106 0.708 rs2416760 chr9:123374639 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.87 0.34 1.31e-8 Hip circumference adjusted for BMI; CESC cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg00255919 chr5:131827918 IRF1 0.51 8.59 0.47 7.76e-16 Asthma (sex interaction); CESC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs7824557 0.527 rs11785394 chr8:11238029 C/T cg15556689 chr8:8085844 FLJ10661 -0.51 -6.03 -0.35 5.45e-9 Retinal vascular caliber; CESC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg07936489 chr17:37558343 FBXL20 -0.58 -7.38 -0.41 2e-12 Asthma; CESC trans rs10486722 0.575 rs11770999 chr7:41812252 C/T cg16202970 chr6:99283201 POU3F2 -0.48 -6.17 -0.35 2.48e-9 Pit-and-Fissure caries; CESC cis rs763121 0.853 rs138706 chr22:39137834 C/G cg21395723 chr22:39101663 GTPBP1 0.48 6.59 0.38 2.39e-10 Menopause (age at onset); CESC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg18032046 chr6:28092343 ZSCAN16 -0.44 -5.83 -0.34 1.58e-8 Cardiac Troponin-T levels; CESC trans rs2688325 0.520 rs10107710 chr8:3761737 C/T cg00283030 chr2:132056444 LOC440910 0.32 6.14 0.35 3.08e-9 Menarche (age at onset); CESC cis rs9359856 0.510 rs6454775 chr6:90465000 A/T cg13799429 chr6:90582589 CASP8AP2 0.69 7.74 0.43 2.11e-13 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02433498 chr17:36904779 PCGF2 0.57 6.13 0.35 3.14e-9 Gut microbiome composition (summer); CESC cis rs1707322 0.827 rs6683274 chr1:46241638 T/G cg03146154 chr1:46216737 IPP 0.78 10.44 0.54 1.38e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs722599 0.748 rs731952 chr14:75366447 A/G cg11812906 chr14:75593930 NEK9 0.43 5.2 0.3 3.93e-7 IgG glycosylation; CESC cis rs282587 0.560 rs375527 chr13:113417589 A/G cg02820901 chr13:113351484 ATP11A -0.64 -5.33 -0.31 2.09e-7 Glycated hemoglobin levels; CESC cis rs61931739 0.500 rs12829125 chr12:34314789 A/G cg19457237 chr12:34500585 NA -0.38 -5.15 -0.3 5.03e-7 Morning vs. evening chronotype; CESC cis rs74181299 0.784 rs2723082 chr2:65289623 C/T cg05010058 chr2:65284262 CEP68 0.34 5.68 0.33 3.57e-8 Pulse pressure; CESC cis rs2742417 0.603 rs6807438 chr3:45778623 G/A cg04837898 chr3:45731254 SACM1L -0.47 -6.2 -0.36 2.19e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs6500395 1.000 rs7196823 chr16:48616278 G/A cg04672837 chr16:48644449 N4BP1 0.51 6.5 0.37 3.95e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs78456975 0.739 rs11891867 chr2:1517894 C/T cg01028140 chr2:1542097 TPO -0.51 -5.61 -0.33 5.01e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9888739 1.000 rs11860650 chr16:31326706 C/T cg15817542 chr16:31343056 ITGAM -0.46 -5.46 -0.32 1.11e-7 Systemic lupus erythematosus; CESC cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg12311346 chr5:56204834 C5orf35 0.64 8.44 0.46 2.06e-15 Initial pursuit acceleration; CESC cis rs2806561 0.765 rs2776815 chr1:23510584 C/T cg12483005 chr1:23474871 LUZP1 -0.38 -5.97 -0.34 7.41e-9 Height; CESC trans rs11098499 0.909 rs11098530 chr4:120413154 C/T cg25214090 chr10:38739885 LOC399744 0.72 10.08 0.53 1.97e-20 Corneal astigmatism; CESC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.72 0.33 2.87e-8 Menopause (age at onset); CESC cis rs4835473 0.932 rs62337619 chr4:144663236 C/T cg25736465 chr4:144833511 NA -0.42 -6.35 -0.36 9.11e-10 Immature fraction of reticulocytes; CESC cis rs35110281 0.805 rs2838319 chr21:44991901 A/G cg21573476 chr21:45109991 RRP1B -0.43 -5.94 -0.34 8.72e-9 Mean corpuscular volume; CESC cis rs6976053 0.541 rs314359 chr7:100411278 T/C cg03098644 chr7:100410630 EPHB4 -0.51 -6.76 -0.38 8.92e-11 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs5769765 1.000 rs5769760 chr22:50259696 A/G cg26441486 chr22:50317300 CRELD2 -0.4 -5.56 -0.32 6.48e-8 Schizophrenia; CESC cis rs3820068 0.603 rs35509554 chr1:15993514 C/T cg16988262 chr1:15930761 NA 0.33 5.32 0.31 2.2e-7 Systolic blood pressure; CESC cis rs4642101 0.618 rs11128614 chr3:12819212 A/G cg24848339 chr3:12840334 CAND2 0.4 6.05 0.35 4.93e-9 QRS complex (12-leadsum); CESC cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.11 0.3 6.22e-7 Hip circumference adjusted for BMI; CESC cis rs2228479 0.702 rs17177891 chr16:89799950 C/T cg00800038 chr16:89945340 TCF25 -0.76 -6.19 -0.36 2.29e-9 Skin colour saturation; CESC cis rs6500395 1.000 rs9936454 chr16:48617782 T/G cg04672837 chr16:48644449 N4BP1 0.51 6.31 0.36 1.14e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4728302 0.559 rs12707093 chr7:133200817 C/T cg10665199 chr7:133106180 EXOC4 0.5 6.65 0.38 1.71e-10 Intelligence;Intelligence (multi-trait analysis); CESC cis rs6460942 1.000 rs79659770 chr7:12326371 T/C cg10578991 chr7:12443926 VWDE -0.61 -6.33 -0.36 1.04e-9 Coronary artery disease; CESC cis rs9911578 0.935 rs302873 chr17:56769481 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.13 0.3 5.66e-7 Intelligence (multi-trait analysis); CESC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg13126279 chr21:47581558 C21orf56 -0.48 -6.54 -0.37 3.09e-10 Testicular germ cell tumor; CESC cis rs1451375 0.572 rs68011952 chr7:50638128 C/T cg14593290 chr7:50529359 DDC 0.44 5.36 0.31 1.82e-7 Malaria; CESC cis rs55692411 0.537 rs13071931 chr3:50062878 G/A cg03060546 chr3:49711283 APEH -0.45 -5.22 -0.31 3.6e-7 Intelligence (multi-trait analysis); CESC cis rs2742234 0.590 rs2742237 chr10:43621323 C/G cg07801480 chr10:43725741 RASGEF1A 0.42 5.37 0.31 1.69e-7 Hirschsprung disease; CESC cis rs7772486 0.624 rs6930154 chr6:146025662 C/T cg23711669 chr6:146136114 FBXO30 -0.9 -13.53 -0.64 4.75e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs1448094 0.817 rs10779220 chr12:86323543 T/A cg02569458 chr12:86230093 RASSF9 0.45 6.43 0.37 5.79e-10 Major depressive disorder; CESC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg13393036 chr8:95962371 TP53INP1 -0.51 -11.06 -0.56 1.28e-23 Type 2 diabetes; CESC cis rs8062405 0.964 rs62036614 chr16:28824685 T/C cg08761264 chr16:28874980 SH2B1 -0.45 -5.47 -0.32 1.05e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2652834 0.851 rs4238370 chr15:63347363 T/G cg05507819 chr15:63340323 TPM1 0.59 5.9 0.34 1.12e-8 HDL cholesterol; CESC cis rs3136441 1.000 rs2306033 chr11:46897446 G/A cg25783544 chr11:47291846 MADD 0.55 5.18 0.3 4.43e-7 HDL cholesterol; CESC cis rs710865 0.516 rs12062540 chr1:19529204 A/G cg13387374 chr1:19411106 UBR4 0.51 7.13 0.4 9.35e-12 Brain structure; CESC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg25985355 chr7:65971099 NA -0.32 -5.29 -0.31 2.61e-7 Aortic root size; CESC cis rs870825 0.860 rs55974219 chr4:185600733 G/A cg04058563 chr4:185651563 MLF1IP 0.57 5.29 0.31 2.54e-7 Blood protein levels; CESC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -6.78 -0.38 7.61e-11 Bipolar disorder; CESC cis rs9581857 0.725 rs1924074 chr13:28015387 C/G cg01674679 chr13:27998804 GTF3A 0.68 5.43 0.32 1.3e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14797243 chr11:68671428 IGHMBP2;MRPL21 -0.49 -7.08 -0.4 1.27e-11 Gambling; CESC trans rs11098499 0.866 rs3756156 chr4:120524841 G/A cg25214090 chr10:38739885 LOC399744 0.67 9.36 0.5 3.52e-18 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25411849 chr6:89855994 PM20D2 0.63 7.69 0.43 2.93e-13 Gut microbiome composition (summer); CESC cis rs9611565 0.649 rs5751108 chr22:41858035 T/C cg06634786 chr22:41940651 POLR3H 0.72 7.39 0.41 1.94e-12 Vitiligo; CESC cis rs7917772 0.560 rs4919664 chr10:104363408 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 5.66 0.33 4.02e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9322193 0.566 rs12528243 chr6:150219627 G/A cg01145232 chr6:150245071 RAET1G 0.53 6.64 0.38 1.79e-10 Lung cancer; CESC cis rs9815354 0.812 rs55748698 chr3:41805233 G/A cg03022575 chr3:42003672 ULK4 0.7 6.18 0.35 2.42e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6580649 0.941 rs17122611 chr12:48458149 C/T cg05342945 chr12:48394962 COL2A1 0.5 5.85 0.34 1.47e-8 Lung cancer; CESC cis rs2204008 0.567 rs2703685 chr12:38081423 G/C cg26384229 chr12:38710491 ALG10B 0.44 5.93 0.34 9.45e-9 Bladder cancer; CESC cis rs7918232 0.941 rs788220 chr10:27447205 T/C cg14442939 chr10:27389572 ANKRD26 -0.68 -6.47 -0.37 4.8e-10 Breast cancer; CESC cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.63 0.61 6.21e-29 Personality dimensions; CESC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg19046167 chr17:80928561 B3GNTL1 0.39 5.26 0.31 2.93e-7 Breast cancer; CESC cis rs6500395 1.000 rs2354579 chr16:48601521 T/C cg04672837 chr16:48644449 N4BP1 0.5 6.28 0.36 1.36e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg02297831 chr4:17616191 MED28 0.6 7.7 0.43 2.71e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3740713 1.000 rs73438695 chr11:18462101 A/G cg23797887 chr11:18477753 LDHAL6A -0.54 -5.28 -0.31 2.63e-7 Amyotrophic lateral sclerosis (sporadic); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21808837 chr5:176778472 LMAN2 0.46 6.29 0.36 1.33e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7809950 0.862 rs58391518 chr7:107030787 T/C cg23024343 chr7:107201750 COG5 -0.42 -5.84 -0.34 1.49e-8 Coronary artery disease; CESC cis rs34172651 0.545 rs9302428 chr16:24717600 C/G cg06028605 chr16:24865363 SLC5A11 -0.38 -5.98 -0.34 7.39e-9 Intelligence (multi-trait analysis); CESC cis rs4132509 0.779 rs4515770 chr1:243686913 A/G cg21452805 chr1:244014465 NA 0.41 5.03 0.3 8.93e-7 RR interval (heart rate); CESC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg23978390 chr7:1156363 C7orf50 0.6 8.4 0.46 2.68e-15 Longevity;Endometriosis; CESC cis rs6952808 0.931 rs12537430 chr7:1868761 A/G cg13880726 chr7:1868755 MAD1L1 -0.52 -7.03 -0.4 1.77e-11 Bipolar disorder and schizophrenia; CESC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg08470875 chr2:26401718 FAM59B -0.48 -5.26 -0.31 2.94e-7 Gut microbiome composition (summer); CESC trans rs1413020 0.660 rs708957 chr20:12771339 C/T cg19784816 chr3:52812520 ITIH1 0.63 6.05 0.35 4.88e-9 Body mass index (recreational physical activity interaction); CESC cis rs11864453 0.928 rs3213420 chr16:72042433 C/T cg01557791 chr16:72042693 DHODH -0.67 -9.27 -0.49 6.64e-18 Fibrinogen levels; CESC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg00684032 chr4:1343700 KIAA1530 0.43 6.12 0.35 3.36e-9 Obesity-related traits; CESC cis rs12824058 0.767 rs4759654 chr12:130815559 A/G cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC trans rs3087243 0.755 rs10490516 chr2:204695788 T/C cg01841312 chr10:38069945 NA -0.38 -6.28 -0.36 1.35e-9 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs3096299 0.748 rs2965822 chr16:89444677 A/T cg16743903 chr16:89593216 SPG7 -0.44 -5.54 -0.32 7.28e-8 Multiple myeloma (IgH translocation); CESC cis rs6456156 0.586 rs12213801 chr6:167474084 T/A cg23791538 chr6:167370224 RNASET2 -0.52 -6.7 -0.38 1.24e-10 Primary biliary cholangitis; CESC cis rs7762018 1.000 rs4716375 chr6:170071218 A/C cg13891659 chr6:170190454 C6orf122;C6orf208 0.53 5.41 0.32 1.43e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs11608355 0.521 rs6606704 chr12:109814036 T/C cg19025524 chr12:109796872 NA -0.53 -7.76 -0.43 1.83e-13 Neuroticism; CESC trans rs2415984 0.846 rs10146907 chr14:46853617 G/T cg14945696 chr3:52713679 PBRM1 -0.4 -6.03 -0.35 5.55e-9 Number of children ever born; CESC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg13393036 chr8:95962371 TP53INP1 -0.49 -10.52 -0.54 7.38e-22 Type 2 diabetes; CESC cis rs7818688 0.614 rs12056517 chr8:95877285 C/T cg16049864 chr8:95962084 TP53INP1 0.51 5.28 0.31 2.7e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg06221963 chr1:154839813 KCNN3 0.65 10.91 0.56 3.88e-23 Prostate cancer; CESC cis rs2730245 0.592 rs2657385 chr7:158649373 A/G cg14689365 chr7:158441557 NCAPG2 0.45 5.65 0.33 4.04e-8 Height; CESC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg07701084 chr6:150067640 NUP43 0.46 6.25 0.36 1.64e-9 Lung cancer; CESC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg12311346 chr5:56204834 C5orf35 0.64 8.43 0.46 2.26e-15 Initial pursuit acceleration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10932289 chr17:55038442 COIL -0.51 -6.61 -0.38 2.06e-10 Fibrinogen levels; CESC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg09455208 chr3:40491958 NA -0.48 -8.27 -0.45 6.6e-15 Renal cell carcinoma; CESC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10832476 chr1:28476863 PTAFR -0.6 -7.36 -0.41 2.37e-12 Gut microbiome composition (summer); CESC cis rs78456975 1.000 rs111935361 chr2:1554192 C/A cg26248373 chr2:1572462 NA -0.58 -5.22 -0.31 3.68e-7 Placebo response in major depressive disorder (% change in symptom score); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00345621 chr19:1277218 C19orf24 0.48 6.8 0.39 6.75e-11 Fibrinogen levels; CESC cis rs11997175 0.583 rs7464599 chr8:33817572 G/A ch.8.33884649F chr8:33765107 NA 0.44 5.39 0.31 1.59e-7 Body mass index; CESC cis rs453301 0.686 rs7017868 chr8:8873293 G/A cg15556689 chr8:8085844 FLJ10661 -0.47 -5.62 -0.33 4.95e-8 Joint mobility (Beighton score); CESC cis rs78456975 0.941 rs13423300 chr2:1553809 C/A cg26248373 chr2:1572462 NA -0.58 -5.48 -0.32 9.71e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.34 0.63 2.04e-31 Prudent dietary pattern; CESC cis rs62408225 0.962 rs1604830 chr6:90969221 T/C cg06866423 chr6:90926672 BACH2 0.45 5.35 0.31 1.9e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.43 0.32 1.27e-7 Bipolar disorder; CESC cis rs10751667 0.643 rs10902244 chr11:949981 A/G cg20946044 chr11:1010712 AP2A2 -0.39 -5.35 -0.31 1.86e-7 Alzheimer's disease (late onset); CESC cis rs2629540 0.889 rs10901808 chr10:126399159 A/C cg08799069 chr10:126477246 METTL10 0.59 7.56 0.42 6.73e-13 Cocaine dependence; CESC cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg17366294 chr4:99064904 C4orf37 0.56 7.71 0.43 2.56e-13 Colonoscopy-negative controls vs population controls; CESC cis rs2637266 0.783 rs12268496 chr10:78487192 G/A cg18941641 chr10:78392320 NA 0.42 8.05 0.44 2.88e-14 Pulmonary function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08892416 chr16:89800313 ZNF276 0.41 6.13 0.35 3.25e-9 Fibrinogen levels; CESC cis rs7680126 0.585 rs34768406 chr4:10118350 C/A cg11266682 chr4:10021025 SLC2A9 -0.48 -5.76 -0.33 2.31e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg25072359 chr17:41440525 NA 0.46 6.24 0.36 1.76e-9 Menopause (age at onset); CESC cis rs78366141 0.649 rs7674009 chr4:89683324 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 -0.68 -5.24 -0.31 3.2e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs698833 1.000 rs698834 chr2:44736957 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.44 5.1 0.3 6.4e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs2637266 0.905 rs2579772 chr10:78406555 A/G cg18941641 chr10:78392320 NA 0.44 8.55 0.47 9.68e-16 Pulmonary function; CESC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg07395648 chr5:131743802 NA 0.39 5.05 0.3 8.31e-7 Acylcarnitine levels; CESC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs10504229 0.593 rs7000752 chr8:58026980 C/G cg22535103 chr8:58192502 C8orf71 -0.57 -6.51 -0.37 3.67e-10 Developmental language disorder (linguistic errors); CESC cis rs7927771 0.864 rs10838724 chr11:47527052 G/T cg05585544 chr11:47624801 NA -0.54 -8.38 -0.46 3.09e-15 Subjective well-being; CESC trans rs61931739 0.500 rs6488222 chr12:34526289 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.31e-22 Morning vs. evening chronotype; CESC cis rs74181299 0.717 rs11893423 chr2:65350949 G/A cg05010058 chr2:65284262 CEP68 -0.32 -5.19 -0.3 4.14e-7 Pulse pressure; CESC cis rs9443189 0.737 rs2842553 chr6:76456632 A/T cg01950844 chr6:76311363 SENP6 -0.62 -6.7 -0.38 1.27e-10 Prostate cancer; CESC trans rs1814175 0.645 rs4411280 chr11:49962750 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -19.0 -0.76 2.27e-51 Height; CESC cis rs6540559 0.673 rs17015309 chr1:210007218 C/T cg23283495 chr1:209979779 IRF6 0.47 5.24 0.31 3.24e-7 Cleft lip with or without cleft palate; CESC cis rs1707322 1.000 rs1588663 chr1:46548825 G/A cg03146154 chr1:46216737 IPP -0.69 -9.04 -0.49 3.51e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1707322 1.000 rs4660335 chr1:46474718 C/T cg05343316 chr1:45956843 TESK2 0.48 5.79 0.33 2.03e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs116095464 0.558 rs10077076 chr5:231940 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.43 0.32 1.3e-7 Breast cancer; CESC cis rs7223966 1.000 rs7214312 chr17:61870863 A/G cg11494091 chr17:61959527 GH2 0.38 5.17 0.3 4.56e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg18252515 chr7:66147081 NA -0.41 -5.29 -0.31 2.55e-7 Aortic root size; CESC cis rs11247915 0.501 rs34209692 chr1:26608782 C/T cg04990556 chr1:26633338 UBXN11 -0.62 -6.88 -0.39 4.24e-11 Obesity-related traits; CESC cis rs7208859 0.623 rs122898 chr17:28905254 C/T cg13385521 chr17:29058706 SUZ12P -0.74 -5.59 -0.32 5.64e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg05564831 chr3:52568323 NT5DC2 0.42 6.17 0.35 2.54e-9 Bipolar disorder; CESC cis rs677665 0.537 rs72641835 chr1:9336748 C/T cg25755851 chr1:9335794 NA 0.95 13.63 0.64 2.08e-32 Eosinophil percentage of white cells; CESC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg05368731 chr17:41323189 NBR1 0.76 10.35 0.54 2.73e-21 Menopause (age at onset); CESC cis rs7020830 0.825 rs7036132 chr9:37317241 A/G cg14294708 chr9:37120828 ZCCHC7 1.23 22.88 0.81 1.06e-64 Schizophrenia; CESC cis rs7727544 0.735 rs273913 chr5:131661156 A/G cg24060327 chr5:131705240 SLC22A5 -0.65 -8.4 -0.46 2.78e-15 Blood metabolite levels; CESC cis rs6500602 0.727 rs12443748 chr16:4541831 C/T cg08645402 chr16:4508243 NA 0.57 9.16 0.49 1.5e-17 Schizophrenia; CESC cis rs10883723 0.810 rs6584508 chr10:104258567 A/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.09 0.3 6.82e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs8017423 0.967 rs8022531 chr14:90729931 T/C cg14092571 chr14:90743983 NA -0.56 -8.38 -0.46 3.07e-15 Mortality in heart failure; CESC cis rs9399135 0.967 rs1041481 chr6:135335063 G/A cg22676075 chr6:135203613 NA 0.52 7.4 0.41 1.84e-12 Red blood cell count; CESC cis rs71403859 0.614 rs12149533 chr16:71801946 C/T cg08717414 chr16:71523259 ZNF19 -0.71 -5.96 -0.34 8.03e-9 Post bronchodilator FEV1; CESC cis rs2239547 0.522 rs9831409 chr3:52985711 A/T cg11645453 chr3:52864694 ITIH4 -0.32 -5.39 -0.31 1.53e-7 Schizophrenia; CESC cis rs6912958 0.559 rs183599 chr6:88061024 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.33 5.46 0.32 1.09e-7 Monocyte percentage of white cells; CESC cis rs9611565 0.840 rs4822025 chr22:41776646 C/G cg06634786 chr22:41940651 POLR3H -0.7 -7.43 -0.42 1.53e-12 Vitiligo; CESC cis rs9486719 0.948 rs11152953 chr6:96894305 C/T cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs9611565 0.802 rs4822028 chr22:41789408 A/G cg06481639 chr22:41940642 POLR3H -0.58 -6.36 -0.36 8.92e-10 Vitiligo; CESC cis rs12824058 0.831 rs4759452 chr12:130812799 G/A cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs116095464 0.542 rs28650039 chr5:273954 C/A cg22496380 chr5:211416 CCDC127 -0.75 -8.66 -0.47 4.78e-16 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03573187 chr11:62439866 C11orf48 -0.45 -6.55 -0.37 3.04e-10 Gambling; CESC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg18350739 chr11:68623251 NA -0.47 -6.93 -0.39 3.29e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs644799 0.511 rs1016030 chr11:95472693 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.41 5.18 0.3 4.33e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs116095464 0.558 rs7731089 chr5:290422 A/C cg10591111 chr5:226296 SDHA -0.53 -6.43 -0.37 6.03e-10 Breast cancer; CESC cis rs10489202 0.632 rs202259 chr1:167962072 G/A cg24449463 chr1:168025552 DCAF6 -0.43 -5.53 -0.32 7.55e-8 Schizophrenia; CESC cis rs6662572 1.000 rs7517111 chr1:46122140 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.53 5.83 0.34 1.65e-8 Blood protein levels; CESC trans rs747782 0.527 rs75915859 chr11:48232931 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.34 0.36 1e-9 Intraocular pressure; CESC cis rs17253792 0.915 rs78089630 chr14:56178584 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.73 5.13 0.3 5.7e-7 Putamen volume; CESC cis rs4974559 0.947 rs28509315 chr4:1358107 C/T cg02980000 chr4:1222292 CTBP1 0.75 6.84 0.39 5.52e-11 Systolic blood pressure; CESC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg08470875 chr2:26401718 FAM59B -0.61 -6.52 -0.37 3.54e-10 Gut microbiome composition (summer); CESC cis rs6446731 0.517 rs2858086 chr4:3270611 A/G cg08886695 chr4:3369023 RGS12 0.38 5.61 0.33 5.03e-8 Mean platelet volume; CESC cis rs2486288 0.656 rs11632752 chr15:45551140 A/G cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs7208859 0.623 rs73269916 chr17:29096326 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.56 0.37 2.85e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs73110464 0.609 rs11170348 chr12:53355588 A/G cg16329197 chr12:53359506 NA -0.71 -10.31 -0.53 3.6e-21 Cancer (pleiotropy); CESC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.76 6.69 0.38 1.3e-10 Platelet count; CESC cis rs11574514 1.000 rs9928374 chr16:67811930 A/G cg01866162 chr16:67596514 CTCF -0.94 -5.88 -0.34 1.26e-8 Crohn's disease; CESC cis rs7167736 0.637 rs2467748 chr15:101206130 A/G cg09499109 chr15:101097659 NA 0.4 5.06 0.3 7.97e-7 Chin dimples; CESC trans rs2235573 0.551 rs139893 chr22:38393608 G/A cg19894588 chr14:64061835 NA 0.59 7.71 0.43 2.55e-13 Glioblastoma;Glioma; CESC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg07677032 chr17:61819896 STRADA 0.47 6.23 0.36 1.83e-9 Prudent dietary pattern; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20149956 chr1:249132233 ZNF672 -0.44 -6.01 -0.35 6.23e-9 Ulcerative colitis; CESC cis rs2180341 0.960 rs7766942 chr6:127691323 G/T cg27446573 chr6:127587934 RNF146 1.05 15.58 0.69 2.65e-39 Breast cancer; CESC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg20203395 chr5:56204925 C5orf35 -0.39 -5.27 -0.31 2.86e-7 Initial pursuit acceleration; CESC cis rs6740322 0.895 rs6711966 chr2:43561989 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.58 -6.39 -0.37 7.6e-10 Coronary artery disease; CESC cis rs1775715 0.870 rs11008700 chr10:32236937 A/G cg18675610 chr10:32216311 ARHGAP12 0.33 5.18 0.3 4.45e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs8072100 0.713 rs8074451 chr17:45477573 C/T cg25173405 chr17:45401733 C17orf57 -0.44 -5.48 -0.32 9.72e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs56235845 0.694 rs6876677 chr5:176755342 T/C cg16006841 chr5:176797999 RGS14 0.48 6.19 0.36 2.26e-9 Hemoglobin concentration;Hematocrit; CESC cis rs9796 0.835 rs3100807 chr15:41292206 G/A cg18705301 chr15:41695430 NDUFAF1 0.43 6.36 0.36 8.58e-10 Menopause (age at onset); CESC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg19318889 chr4:1322082 MAEA 0.46 6.33 0.36 1.04e-9 Longevity; CESC cis rs7772486 0.748 rs2748484 chr6:146333653 C/T cg23711669 chr6:146136114 FBXO30 0.78 11.1 0.56 8.97e-24 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11817453 chr19:8464850 RAB11B 0.46 6.25 0.36 1.6e-9 Fibrinogen levels; CESC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg23708337 chr7:1209742 NA 0.52 5.14 0.3 5.37e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6429082 0.715 rs9793740 chr1:235595590 T/C cg26050004 chr1:235667680 B3GALNT2 -0.53 -6.73 -0.38 1.03e-10 Adiposity; CESC cis rs8002861 0.875 rs12428432 chr13:44464043 A/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.47 -6.02 -0.35 5.84e-9 Leprosy; CESC cis rs225245 0.817 rs225299 chr17:33922742 T/C cg05299278 chr17:33885742 SLFN14 0.37 5.31 0.31 2.27e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg05283184 chr6:79620031 NA -0.41 -6.34 -0.36 9.98e-10 Intelligence (multi-trait analysis); CESC cis rs6582630 0.519 rs1607882 chr12:38361657 G/A cg26384229 chr12:38710491 ALG10B 0.67 9.9 0.52 7.06e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs7605378 0.658 rs4673507 chr2:200710167 G/C cg17644776 chr2:200775616 C2orf69 0.42 5.44 0.32 1.22e-7 Osteoporosis; CESC cis rs7580658 0.724 rs6712213 chr2:127998230 G/A cg10021288 chr2:128175891 PROC -0.4 -6.23 -0.36 1.83e-9 Protein C levels; CESC cis rs1387259 0.929 rs11168484 chr12:48633589 A/C cg04545296 chr12:48745243 ZNF641 0.41 6.86 0.39 4.97e-11 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs1707322 0.963 rs4553121 chr1:46375253 G/A cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10204999 chr14:103057895 RCOR1 -0.4 -6.24 -0.36 1.71e-9 Gambling; CESC cis rs644799 1.000 rs534497 chr11:95562868 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 14.05 0.65 6.75e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg27478167 chr7:817139 HEATR2 -0.46 -5.38 -0.31 1.68e-7 Cerebrospinal P-tau181p levels; CESC cis rs9303280 0.901 rs12103884 chr17:38045725 C/T cg20243544 chr17:37824526 PNMT 0.52 6.83 0.39 5.73e-11 Self-reported allergy; CESC cis rs12541635 0.966 rs114386112 chr8:107036340 G/A cg10147462 chr8:107024639 NA 0.43 6.04 0.35 5.26e-9 Age of smoking initiation; CESC cis rs1568889 0.667 rs16917914 chr11:28459909 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 7.57 0.42 6.32e-13 Bipolar disorder; CESC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.61 0.42 4.89e-13 Prudent dietary pattern; CESC cis rs7395581 0.918 rs7120957 chr11:47340649 A/G cg25783544 chr11:47291846 MADD 0.61 7.9 0.44 7.43e-14 HDL cholesterol; CESC cis rs9549367 0.789 rs2287251 chr13:113889499 A/G cg00898013 chr13:113819073 PROZ -0.5 -6.86 -0.39 4.95e-11 Platelet distribution width; CESC cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg02079420 chr8:82753780 SNX16 0.58 7.63 0.42 4.14e-13 Diastolic blood pressure; CESC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs936229 0.626 rs3765066 chr15:75140854 G/A cg14664628 chr15:75095509 CSK -0.64 -9.28 -0.5 6.27e-18 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs763121 0.853 rs8142098 chr22:39058757 T/G cg14440974 chr22:39074834 NA -0.4 -5.5 -0.32 9.03e-8 Menopause (age at onset); CESC cis rs9811920 0.609 rs6765027 chr3:99687730 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.6 -7.21 -0.4 5.96e-12 Axial length; CESC cis rs9287719 0.967 rs728134 chr2:10745187 A/G cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg09658497 chr7:2847517 GNA12 -0.33 -5.08 -0.3 7.14e-7 Height; CESC cis rs1348850 0.914 rs12469386 chr2:178358281 A/G cg23306229 chr2:178417860 TTC30B -0.64 -8.35 -0.46 3.79e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4555082 0.957 rs2735818 chr14:105714751 A/G cg27165867 chr14:105738592 BRF1 -0.46 -5.27 -0.31 2.82e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7123876 0.553 rs10898868 chr11:72431679 A/G cg04827223 chr11:72435913 ARAP1 -0.62 -10.36 -0.54 2.37e-21 Body mass index; CESC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg02569458 chr12:86230093 RASSF9 0.57 8.39 0.46 3e-15 Major depressive disorder; CESC cis rs56104184 0.775 rs55737338 chr19:49403141 A/G cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg17949981 chr6:28129498 ZNF389 0.45 5.71 0.33 3.07e-8 Depression; CESC cis rs4481887 0.732 rs6703399 chr1:248416343 T/C cg00666640 chr1:248458726 OR2T12 0.4 6.53 0.37 3.27e-10 Common traits (Other); CESC cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg10556349 chr10:835070 NA 0.61 5.86 0.34 1.35e-8 Eosinophil percentage of granulocytes; CESC cis rs317689 0.819 rs317685 chr12:69715457 A/G cg20891283 chr12:69753455 YEATS4 -0.47 -5.1 -0.3 6.38e-7 Response to diuretic therapy; CESC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg04944784 chr2:26401820 FAM59B 0.74 8.26 0.45 7e-15 Gut microbiome composition (summer); CESC cis rs2302190 0.882 rs7226008 chr17:56644633 T/C cg25885038 chr17:56607967 SEPT4 -0.4 -5.43 -0.32 1.27e-7 Vitamin D levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26871885 chr11:207525 RIC8A;BET1L -0.44 -6.08 -0.35 4.1e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7084402 1.000 rs7917717 chr10:60269100 C/A cg07615347 chr10:60278583 BICC1 -0.57 -8.73 -0.47 2.82e-16 Refractive error; CESC cis rs4835473 0.750 rs12498381 chr4:144715081 G/A cg25736465 chr4:144833511 NA -0.35 -5.83 -0.34 1.59e-8 Immature fraction of reticulocytes; CESC cis rs763014 0.833 rs916415 chr16:632115 G/A cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.73 0.38 1.02e-10 Prudent dietary pattern; CESC cis rs3096299 0.900 rs2911258 chr16:89480760 A/G cg08392591 chr16:89556376 ANKRD11 0.42 5.47 0.32 1.03e-7 Multiple myeloma (IgH translocation); CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg21086083 chr2:157191261 NA -0.57 -6.86 -0.39 4.79e-11 Gut microbiota (bacterial taxa); CESC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 4.97e-9 Prudent dietary pattern; CESC cis rs10242455 0.867 rs2687144 chr7:99318808 C/T cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg11965913 chr1:205819406 PM20D1 0.51 7.64 0.42 4.07e-13 Menarche (age at onset); CESC cis rs752010 0.543 rs7545381 chr1:42044183 T/A cg06885757 chr1:42089581 HIVEP3 0.46 7.46 0.42 1.28e-12 Lupus nephritis in systemic lupus erythematosus; CESC cis rs1018836 0.923 rs2105967 chr8:91587522 A/G cg16814680 chr8:91681699 NA -0.65 -8.72 -0.47 3.08e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1348850 0.526 rs2178017 chr2:178374788 G/T cg23306229 chr2:178417860 TTC30B 0.78 6.93 0.39 3.16e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11098499 0.954 rs11935596 chr4:120412457 G/C cg24375607 chr4:120327624 NA 0.46 5.63 0.33 4.52e-8 Corneal astigmatism; CESC cis rs9303401 0.614 rs66480139 chr17:57101538 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.87 10.87 0.56 5.18e-23 Cognitive test performance; CESC cis rs147858478 1 rs147858478 chr5:131682785 CCTGAGTT/C cg24060327 chr5:131705240 SLC22A5 -0.67 -8.91 -0.48 8.52e-17 High light scatter reticulocyte percentage of red cells; CESC cis rs11997175 0.713 rs4327826 chr8:33654807 T/G ch.8.33884649F chr8:33765107 NA 0.57 7.3 0.41 3.26e-12 Body mass index; CESC trans rs7246657 0.882 rs10412043 chr19:37826626 A/C cg24637308 chr11:6592297 DNHD1 0.53 6.19 0.36 2.22e-9 Coronary artery calcification; CESC cis rs478304 0.651 rs11604451 chr11:65551710 C/T cg10518572 chr11:65560635 OVOL1 -0.3 -5.69 -0.33 3.38e-8 Acne (severe); CESC cis rs7592578 0.679 rs62181019 chr2:191325414 A/G cg27211696 chr2:191398769 TMEM194B -0.53 -5.42 -0.32 1.36e-7 Diastolic blood pressure; CESC trans rs7246760 0.867 rs68041339 chr19:9818851 A/G cg02900749 chr2:68251473 NA -0.81 -7.26 -0.41 4.4e-12 Pursuit maintenance gain; CESC cis rs2731664 0.792 rs163199 chr5:176890067 A/G cg23176889 chr5:176863531 GRK6 -0.61 -10.72 -0.55 1.61e-22 Intelligence (multi-trait analysis); CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg18099408 chr3:52552593 STAB1 -0.34 -6.3 -0.36 1.22e-9 Bipolar disorder; CESC trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21659725 chr3:3221576 CRBN -0.83 -13.35 -0.63 1.98e-31 Intelligence (multi-trait analysis); CESC cis rs3733585 0.775 rs13124007 chr4:10043931 G/C cg00071950 chr4:10020882 SLC2A9 0.81 13.65 0.64 1.7e-32 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2841277 0.741 rs9672139 chr14:105408182 T/G cg15352829 chr14:105391018 PLD4 -0.58 -10.02 -0.52 3.07e-20 Rheumatoid arthritis; CESC cis rs4481887 0.861 rs10788778 chr1:248481551 T/C cg00666640 chr1:248458726 OR2T12 0.41 6.56 0.37 2.84e-10 Common traits (Other); CESC cis rs2425143 1.000 rs7273174 chr20:34350306 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -6.85 -0.39 5.04e-11 Blood protein levels; CESC cis rs4919044 0.740 rs73319304 chr10:94777045 A/G cg26979504 chr10:94451518 HHEX -0.47 -5.15 -0.3 5.16e-7 Coronary artery disease; CESC cis rs17539620 0.624 rs62432736 chr6:154834401 A/G cg20019720 chr6:154832845 CNKSR3 0.48 6.37 0.36 8.3e-10 Lipoprotein (a) levels; CESC cis rs10465746 0.570 rs6658559 chr1:84467412 A/G cg10977910 chr1:84465055 TTLL7 0.44 5.62 0.33 4.89e-8 Obesity-related traits; CESC cis rs9902453 0.791 rs3115086 chr17:28025949 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.4 0.54 1.88e-21 Coffee consumption (cups per day); CESC cis rs2228479 0.717 rs17233678 chr16:89809962 T/C cg14709524 chr16:89940631 TCF25 0.94 7.08 0.4 1.27e-11 Skin colour saturation; CESC cis rs911555 0.755 rs2273702 chr14:103918182 C/G cg12935359 chr14:103987150 CKB 0.55 7.97 0.44 4.66e-14 Intelligence (multi-trait analysis); CESC cis rs9796 0.689 rs692511 chr15:41446252 A/C cg12426344 chr15:41135900 SPINT1 -0.24 -5.35 -0.31 1.93e-7 Menopause (age at onset); CESC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg07677032 chr17:61819896 STRADA 0.42 5.37 0.31 1.74e-7 Prudent dietary pattern; CESC cis rs897984 0.806 rs10782002 chr16:30946506 A/G cg00531865 chr16:30841666 NA 0.49 6.71 0.38 1.17e-10 Dementia with Lewy bodies; CESC cis rs12579753 0.917 rs11115058 chr12:82263427 T/C cg24719984 chr12:82153464 PPFIA2 -0.35 -5.16 -0.3 4.96e-7 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14227996 chr4:17616232 MED28 0.57 6.01 0.35 6.28e-9 Gut microbiome composition (summer); CESC cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg26597838 chr10:835615 NA 0.83 8.76 0.47 2.39e-16 Eosinophil percentage of granulocytes; CESC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg05368731 chr17:41323189 NBR1 0.61 8.44 0.46 2.11e-15 Menopause (age at onset); CESC cis rs11190604 1.000 rs2489043 chr10:102334327 T/C cg07080220 chr10:102295463 HIF1AN 0.6 5.87 0.34 1.28e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs6991838 0.584 rs73236948 chr8:66521411 T/G cg13398993 chr8:66546079 ARMC1 -0.46 -5.45 -0.32 1.14e-7 Intelligence (multi-trait analysis); CESC cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg06138931 chr13:21896616 NA 0.47 5.94 0.34 8.88e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9486715 0.867 rs1127175 chr6:96999725 C/T cg06623918 chr6:96969491 KIAA0776 -0.84 -12.28 -0.6 9.84e-28 Headache; CESC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.91e-10 Bipolar disorder; CESC cis rs3008870 1.000 rs2985824 chr1:67410171 C/T cg02640540 chr1:67518911 SLC35D1 -0.51 -5.53 -0.32 7.82e-8 Lymphocyte percentage of white cells; CESC cis rs2290159 0.800 rs3773345 chr3:12642945 G/C cg23032965 chr3:12705835 RAF1 0.5 5.47 0.32 1.05e-7 Cholesterol, total; CESC cis rs7259376 0.902 rs10420380 chr19:22600624 C/T cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.79e-7 Menopause (age at onset); CESC cis rs3862260 0.509 rs10923879 chr1:120163831 A/G cg16322792 chr1:120165303 ZNF697 0.58 10.95 0.56 2.82e-23 Systemic lupus erythematosus; CESC cis rs911555 0.755 rs17841064 chr14:103900609 A/G cg24130564 chr14:104152367 KLC1 -0.5 -6.68 -0.38 1.43e-10 Intelligence (multi-trait analysis); CESC cis rs7116495 1.000 rs12283462 chr11:71835406 T/G cg26138937 chr11:71823887 C11orf51 0.8 6.42 0.37 6.17e-10 Severe influenza A (H1N1) infection; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26877631 chr10:21823297 MLLT10 0.47 6.56 0.37 2.75e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7789940 0.904 rs73140040 chr7:75936240 C/T cg10167463 chr7:75959203 YWHAG -0.44 -5.22 -0.31 3.66e-7 Multiple sclerosis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04408576 chr16:1524927 CLCN7 -0.51 -6.52 -0.37 3.48e-10 Ulcerative colitis; CESC cis rs1538970 0.816 rs12029322 chr1:45970446 C/T cg24296786 chr1:45957014 TESK2 -0.46 -5.15 -0.3 4.97e-7 Platelet count; CESC cis rs11722228 1.000 rs4697695 chr4:9915850 C/T cg11266682 chr4:10021025 SLC2A9 0.45 7.61 0.42 4.69e-13 Gout;Urate levels;Serum uric acid levels; CESC cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.864 rs755555 chr11:47431966 C/T cg20307385 chr11:47447363 PSMC3 -0.64 -7.72 -0.43 2.41e-13 Subjective well-being; CESC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.81 0.39 6.5e-11 Platelet count; CESC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg06873352 chr17:61820015 STRADA 0.45 6.57 0.37 2.6e-10 Height; CESC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg13880726 chr7:1868755 MAD1L1 0.52 7.0 0.4 2.07e-11 Bipolar disorder and schizophrenia; CESC cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg12386194 chr3:101231763 SENP7 0.44 5.38 0.31 1.64e-7 Colorectal cancer; CESC cis rs3096299 0.933 rs3096297 chr16:89453155 T/G cg00750074 chr16:89608354 SPG7 -0.38 -5.36 -0.31 1.79e-7 Multiple myeloma (IgH translocation); CESC cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg10556349 chr10:835070 NA 0.76 6.26 0.36 1.54e-9 Eosinophil percentage of granulocytes; CESC cis rs2070488 0.965 rs6599209 chr3:38558197 A/G cg24069376 chr3:38537580 EXOG -0.46 -8.5 -0.46 1.42e-15 Electrocardiographic conduction measures; CESC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -7.95 -0.44 5.57e-14 Personality dimensions; CESC cis rs12995491 0.933 rs13008732 chr2:88528771 G/A cg04511125 chr2:88470314 THNSL2 -0.51 -7.35 -0.41 2.42e-12 Response to metformin (IC50); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08007338 chr1:180123948 QSOX1 0.56 6.33 0.36 1.04e-9 Gut microbiome composition (summer); CESC cis rs75477785 1.000 rs17015255 chr1:209982738 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 -0.93 -5.84 -0.34 1.51e-8 Cleft lip with or without cleft palate; CESC cis rs4253772 0.530 rs6008662 chr22:46713917 G/A cg24881330 chr22:46731750 TRMU 0.86 9.19 0.49 1.18e-17 LDL cholesterol;Cholesterol, total; CESC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg03388025 chr16:89894329 SPIRE2 0.41 8.2 0.45 1.06e-14 Vitiligo; CESC cis rs9346455 1.000 rs9360447 chr6:72023223 T/G cg27238071 chr6:71998145 OGFRL1 0.62 5.58 0.32 6.05e-8 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg00802000 chr16:706648 WDR90 -0.4 -6.1 -0.35 3.76e-9 Height; CESC cis rs7520050 0.778 rs2991985 chr1:46080530 T/C cg06784218 chr1:46089804 CCDC17 -0.33 -6.08 -0.35 4.15e-9 Red blood cell count;Reticulocyte count; CESC cis rs6121246 0.559 rs6060599 chr20:30257754 T/G cg13852791 chr20:30311386 BCL2L1 0.8 10.27 0.53 4.64e-21 Mean corpuscular hemoglobin; CESC cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.72 0.33 2.91e-8 Colonoscopy-negative controls vs population controls; CESC trans rs629535 0.814 rs56301437 chr8:70108518 C/T cg21567404 chr3:27674614 NA -0.87 -10.05 -0.53 2.43e-20 Dupuytren's disease; CESC cis rs2439831 0.702 rs3759791 chr15:44090798 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.79 0.43 1.52e-13 Lung cancer in ever smokers; CESC cis rs7264396 0.563 rs2050729 chr20:34294409 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.62 -6.65 -0.38 1.71e-10 Total cholesterol levels; CESC cis rs8180040 0.620 rs56217494 chr3:47048452 T/G cg27129171 chr3:47204927 SETD2 -0.66 -9.61 -0.51 5.83e-19 Colorectal cancer; CESC cis rs6732160 0.684 rs2043095 chr2:73407442 T/C cg01422370 chr2:73384389 NA 0.45 7.68 0.43 3.02e-13 Intelligence (multi-trait analysis); CESC cis rs9309473 0.948 rs10170849 chr2:73747932 G/A cg20560298 chr2:73613845 ALMS1 -0.45 -6.04 -0.35 5.24e-9 Metabolite levels; CESC cis rs208515 0.525 rs12204706 chr6:66669930 A/G cg07460842 chr6:66804631 NA -0.84 -10.98 -0.56 2.26e-23 Exhaled nitric oxide levels; CESC cis rs561341 0.883 rs7406056 chr17:30220224 C/T cg00745463 chr17:30367425 LRRC37B -0.62 -6.24 -0.36 1.68e-9 Hip circumference adjusted for BMI; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03768513 chr22:24552594 CABIN1 0.46 6.16 0.35 2.66e-9 Gut microbiota (bacterial taxa); CESC cis rs7177699 0.557 rs4380028 chr15:79111093 C/T cg04896959 chr15:78267971 NA 0.32 5.04 0.3 8.54e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25346583 chr19:16296095 FAM32A -0.43 -6.26 -0.36 1.55e-9 Gambling; CESC cis rs938554 0.558 rs4697701 chr4:9946095 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -6.79 -0.39 7.18e-11 Blood metabolite levels; CESC cis rs11098499 0.954 rs4309825 chr4:120314881 C/T cg09160332 chr4:120329925 NA 0.38 5.16 0.3 4.82e-7 Corneal astigmatism; CESC trans rs11252926 0.550 rs10795122 chr10:466830 C/T cg00953403 chr17:74099816 EXOC7 0.53 6.59 0.38 2.3e-10 Psychosis in Alzheimer's disease; CESC cis rs9309473 0.950 rs6546847 chr2:73785358 A/G cg20560298 chr2:73613845 ALMS1 -0.48 -6.44 -0.37 5.5e-10 Metabolite levels; CESC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg07677032 chr17:61819896 STRADA 0.46 6.1 0.35 3.83e-9 Prudent dietary pattern; CESC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg18404041 chr3:52824283 ITIH1 -0.41 -6.78 -0.38 7.75e-11 Bipolar disorder; CESC cis rs9303401 0.659 rs17822735 chr17:56620167 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.54e-29 Cognitive test performance; CESC cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg06636001 chr8:8085503 FLJ10661 0.43 5.42 0.32 1.37e-7 Mood instability; CESC cis rs7131987 0.903 rs2194520 chr12:29423712 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -5.4 -0.31 1.51e-7 QT interval; CESC cis rs765787 0.530 rs2413782 chr15:45538490 A/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17906179 chr3:194991500 C3orf21 -0.41 -6.43 -0.37 5.93e-10 Gambling; CESC trans rs1814175 0.781 rs12286395 chr11:49954062 C/G cg15704280 chr7:45808275 SEPT13 -1.03 -20.41 -0.78 2.75e-56 Height; CESC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg17724175 chr1:150552817 MCL1 0.33 5.08 0.3 7.11e-7 Melanoma; CESC cis rs11997175 0.766 rs56803376 chr8:33687676 T/C ch.8.33884649F chr8:33765107 NA 0.46 5.94 0.34 8.83e-9 Body mass index; CESC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.6e-11 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.51 0.46 1.3e-15 Colonoscopy-negative controls vs population controls; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00492233 chr7:135242493 NUP205 0.48 6.06 0.35 4.57e-9 Systemic lupus erythematosus; CESC cis rs10465746 0.967 rs11163861 chr1:84354282 T/C cg10977910 chr1:84465055 TTLL7 0.48 6.52 0.37 3.63e-10 Obesity-related traits; CESC cis rs35306767 0.953 rs12259801 chr10:959306 C/G cg26597838 chr10:835615 NA 0.84 9.84 0.52 1.15e-19 Eosinophil percentage of granulocytes; CESC cis rs9611519 0.929 rs12484477 chr22:41429084 G/A cg03806693 chr22:41940476 POLR3H -0.58 -6.02 -0.35 5.67e-9 Neuroticism; CESC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg11644478 chr21:40555479 PSMG1 -0.77 -11.36 -0.57 1.25e-24 Cognitive function; CESC cis rs3741151 0.686 rs7112924 chr11:73106408 C/T cg17517138 chr11:73019481 ARHGEF17 0.82 6.54 0.37 3.21e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs4481887 0.927 rs10749651 chr1:248472930 T/C cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs116095464 0.558 rs62344300 chr5:246336 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.63 -0.47 5.66e-16 Breast cancer; CESC cis rs798766 1.000 rs4865463 chr4:1742400 T/C cg10756475 chr4:1757242 NA 0.48 6.56 0.37 2.85e-10 Bladder cancer;Urinary bladder cancer; CESC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg14393609 chr7:65229607 NA 0.49 6.63 0.38 1.92e-10 Aortic root size; CESC cis rs11871801 0.517 rs645692 chr17:40701073 C/T cg11629889 chr17:40839022 CNTNAP1 0.4 5.11 0.3 6.07e-7 Crohn's disease; CESC cis rs60871478 1.000 rs4719314 chr7:822523 A/G cg05535760 chr7:792225 HEATR2 0.81 8.4 0.46 2.8e-15 Cerebrospinal P-tau181p levels; CESC cis rs2479724 0.846 rs2251084 chr6:41838119 T/C cg08135965 chr6:41755394 TOMM6 0.41 5.5 0.32 9.15e-8 Menarche (age at onset); CESC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg11764359 chr7:65958608 NA 0.73 10.55 0.54 5.73e-22 Aortic root size; CESC cis rs11122272 0.735 rs973254 chr1:231521149 T/A cg06096015 chr1:231504339 EGLN1 0.41 5.85 0.34 1.46e-8 Hemoglobin concentration; CESC cis rs1620921 0.505 rs13216458 chr6:161204262 T/C cg01280913 chr6:161186852 NA -0.36 -5.26 -0.31 2.94e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.735 rs12903874 chr15:76693318 A/T cg23625390 chr15:77176239 SCAPER -0.43 -5.9 -0.34 1.12e-8 Blood metabolite levels; CESC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg04553112 chr3:125709451 NA -0.51 -5.53 -0.32 7.63e-8 Blood pressure (smoking interaction); CESC cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg18357645 chr12:58087776 OS9 -0.43 -5.98 -0.34 7.09e-9 Multiple sclerosis; CESC cis rs3820928 0.874 rs1949807 chr2:227891861 A/G cg11843606 chr2:227700838 RHBDD1 -0.48 -6.39 -0.37 7.49e-10 Pulmonary function; CESC cis rs2066819 1.000 rs773664 chr12:56702176 C/T cg26714650 chr12:56694279 CS 1.28 15.86 0.7 2.7e-40 Psoriasis vulgaris; CESC cis rs4955124 0.558 rs62244392 chr3:32020530 T/C cg05935571 chr3:32023257 ZNF860;OSBPL10 1.0 8.35 0.46 3.75e-15 Schizophrenia; CESC cis rs61996546 0.622 rs17560717 chr15:26834211 G/C cg14859324 chr15:26874363 GABRB3 -0.38 -5.12 -0.3 6e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs763121 0.853 rs5757200 chr22:39043491 T/G cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC cis rs7512552 0.839 rs3896342 chr1:150411312 T/C cg15654264 chr1:150340011 RPRD2 0.39 5.18 0.3 4.42e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs747782 0.702 rs17790804 chr11:47447202 T/C cg25783544 chr11:47291846 MADD 0.63 5.23 0.31 3.4e-7 Intraocular pressure; CESC cis rs16854884 0.837 rs13083068 chr3:143801642 G/T cg06585982 chr3:143692056 C3orf58 0.42 5.29 0.31 2.6e-7 Economic and political preferences (feminism/equality); CESC cis rs7301826 0.651 rs7299281 chr12:131303132 G/A cg11011512 chr12:131303247 STX2 -0.44 -5.36 -0.31 1.81e-7 Plasma plasminogen activator levels; CESC cis rs617791 0.678 rs551659 chr11:65749645 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.74 10.63 0.55 3.14e-22 Breast cancer; CESC cis rs10788264 0.504 rs10749452 chr10:124028141 A/G cg09507567 chr10:124027408 NA 0.39 5.41 0.32 1.42e-7 Total body bone mineral density; CESC cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg00031303 chr3:195681400 NA 0.45 5.65 0.33 4.21e-8 Pancreatic cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04312752 chr5:1801320 NDUFS6;MRPL36 0.52 6.77 0.38 8.46e-11 Gut microbiota (bacterial taxa); CESC cis rs854765 0.623 rs9893690 chr17:17753846 A/T cg04398451 chr17:18023971 MYO15A 0.66 9.82 0.52 1.33e-19 Total body bone mineral density; CESC cis rs1669338 0.588 rs3864049 chr3:3186719 T/G cg16797762 chr3:3221439 CRBN -0.61 -6.42 -0.37 6.21e-10 White matter integrity; CESC cis rs6141600 0.661 rs1001043 chr20:34730674 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -5.14 -0.3 5.21e-7 Height;Hip circumference; CESC cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg19717773 chr7:2847554 GNA12 -0.56 -8.68 -0.47 4.11e-16 Height; CESC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.38 -6.64 -0.38 1.79e-10 Bipolar disorder; CESC cis rs748404 0.631 rs560191 chr15:43767774 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.21 0.45 9.59e-15 Lung cancer; CESC cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg18850127 chr7:39170497 POU6F2 0.37 5.18 0.3 4.43e-7 IgG glycosylation; CESC cis rs10504229 0.871 rs56048296 chr8:58163781 C/T cg22535103 chr8:58192502 C8orf71 -0.86 -11.2 -0.57 4.33e-24 Developmental language disorder (linguistic errors); CESC cis rs9640161 0.750 rs4395803 chr7:150025367 A/C cg10018233 chr7:150070692 REPIN1 0.46 6.99 0.39 2.28e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs9831754 0.704 rs1512492 chr3:78471190 A/C cg06138941 chr3:78371609 NA -0.41 -5.37 -0.31 1.72e-7 Calcium levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg17774058 chr20:6748719 BMP2 -0.42 -6.11 -0.35 3.59e-9 Height; CESC trans rs4596713 0.508 rs7467352 chr9:71766081 G/A cg16512924 chr15:28394682 HERC2 0.5 6.38 0.36 7.96e-10 Headache; CESC trans rs1814175 0.715 rs11040586 chr11:49858432 T/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.98 -0.78 8.73e-55 Height; CESC cis rs3733585 0.648 rs28513781 chr4:9959334 G/C cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21416968 chr1:44441199 ATP6V0B -0.41 -6.33 -0.36 1.06e-9 Gambling; CESC cis rs11098499 0.954 rs11940028 chr4:120411907 T/C cg09307838 chr4:120376055 NA 0.92 12.96 0.62 4.27e-30 Corneal astigmatism; CESC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Parkinson's disease; CESC cis rs2425143 0.643 rs6058324 chr20:34388789 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 7.72e-12 Blood protein levels; CESC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg08470875 chr2:26401718 FAM59B -0.62 -6.69 -0.38 1.35e-10 Gut microbiome composition (summer); CESC cis rs9584850 0.874 rs3742136 chr13:99102607 C/T cg22223119 chr13:99095684 FARP1 -0.37 -5.26 -0.31 2.94e-7 Neuroticism; CESC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg27170947 chr2:26402098 FAM59B -0.59 -7.07 -0.4 1.36e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08541880 chr3:137833983 DZIP1L 0.63 7.22 0.41 5.56e-12 Gut microbiome composition (summer); CESC cis rs8031584 1.000 rs35607976 chr15:31277788 T/C cg08704250 chr15:31115839 NA -0.69 -8.45 -0.46 2e-15 Huntington's disease progression; CESC cis rs7827545 1.000 rs7823948 chr8:135566580 G/A cg17885191 chr8:135476712 NA 0.48 6.28 0.36 1.35e-9 Hypertension (SNP x SNP interaction); CESC cis rs7267979 0.549 rs6138536 chr20:25182648 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.66 10.55 0.54 6.11e-22 Liver enzyme levels (alkaline phosphatase); CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg05157120 chr14:69727352 GALNTL1 -0.53 -6.3 -0.36 1.26e-9 Lung cancer in ever smokers; CESC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg24578937 chr1:2090814 PRKCZ -0.32 -5.56 -0.32 6.55e-8 Height; CESC cis rs959260 0.623 rs7207618 chr17:73321687 T/C cg12999837 chr17:73267436 MIF4GD -0.42 -5.15 -0.3 5.03e-7 Systemic lupus erythematosus; CESC cis rs6690583 0.623 rs12042018 chr1:85436937 T/C cg22153463 chr1:85462885 MCOLN2 0.77 7.23 0.41 5.04e-12 Serum sulfate level; CESC cis rs2742417 0.587 rs2742375 chr3:45784602 G/A cg04837898 chr3:45731254 SACM1L -0.46 -6.02 -0.35 5.82e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs2228479 0.850 rs62052660 chr16:89847420 T/A cg14709524 chr16:89940631 TCF25 0.94 7.07 0.4 1.41e-11 Skin colour saturation; CESC cis rs2797160 0.904 rs1777197 chr6:126007401 G/A cg05901451 chr6:126070800 HEY2 0.46 6.48 0.37 4.35e-10 Endometrial cancer; CESC cis rs6831352 0.918 rs29001203 chr4:100053091 A/G cg13256891 chr4:100009986 ADH5 -0.73 -8.31 -0.45 4.94e-15 Alcohol dependence; CESC cis rs7639513 0.767 rs2348201 chr3:12711696 A/G cg23032965 chr3:12705835 RAF1 0.75 10.39 0.54 2.02e-21 Itch intensity from mosquito bite; CESC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg24324837 chr19:49891574 CCDC155 0.49 5.56 0.32 6.47e-8 Multiple sclerosis; CESC cis rs36051895 0.623 rs2146040 chr9:5260039 C/G cg02405213 chr9:5042618 JAK2 0.51 6.44 0.37 5.68e-10 Pediatric autoimmune diseases; CESC cis rs929354 0.742 rs3808317 chr7:156944460 A/G cg05182265 chr7:156933206 UBE3C -0.5 -7.29 -0.41 3.49e-12 Body mass index; CESC cis rs708547 0.533 rs3806746 chr4:57773330 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.52 -6.66 -0.38 1.59e-10 Response to bleomycin (chromatid breaks); CESC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg22143856 chr6:28129313 ZNF389 0.44 5.49 0.32 9.24e-8 Parkinson's disease; CESC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg03605463 chr16:89740564 NA 0.63 7.57 0.42 6.39e-13 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04407233 chr1:10042538 NMNAT1 0.48 6.6 0.38 2.28e-10 Fibrinogen levels; CESC cis rs35955747 0.869 rs8143002 chr22:31587191 T/C cg25791279 chr22:32026902 PISD -0.48 -5.79 -0.33 2.01e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs9303280 0.685 rs9916765 chr17:38005595 T/C cg19468946 chr17:37922297 IKZF3 -0.38 -5.31 -0.31 2.33e-7 Self-reported allergy; CESC cis rs3806843 0.868 rs2531349 chr5:140120953 G/A cg16179182 chr5:140090404 VTRNA1-1 0.38 5.04 0.3 8.79e-7 Depressive symptoms (multi-trait analysis); CESC cis rs79387448 0.614 rs6719130 chr2:102958236 C/T cg09003973 chr2:102972529 NA 1.13 8.98 0.48 5.2e-17 Gut microbiota (bacterial taxa); CESC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg24399712 chr22:39784796 NA -0.84 -11.79 -0.59 4.45e-26 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9488822 0.702 rs12196154 chr6:116327471 T/G cg15226275 chr6:116381976 FRK 0.25 6.18 0.35 2.39e-9 Cholesterol, total;LDL cholesterol; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24541279 chr10:71993373 PPA1 -0.49 -6.44 -0.37 5.7e-10 Fibrinogen levels; CESC cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg15017067 chr4:17643749 FAM184B 0.41 5.94 0.34 8.84e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7980687 0.638 rs7299943 chr12:123593485 A/T cg00376283 chr12:123451042 ABCB9 0.74 8.85 0.48 1.32e-16 Height;Educational attainment;Head circumference (infant); CESC cis rs2996428 0.667 rs16824230 chr1:3766240 A/G cg13057898 chr1:3703894 LRRC47 0.47 6.77 0.38 8.42e-11 Red cell distribution width; CESC cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg05585544 chr11:47624801 NA -0.49 -7.25 -0.41 4.56e-12 Subjective well-being; CESC cis rs2204008 0.639 rs7311462 chr12:38278130 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.26 0.53 5.3e-21 Bladder cancer; CESC cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg08917208 chr2:24149416 ATAD2B 0.66 6.39 0.37 7.45e-10 Lymphocyte counts; CESC cis rs6748734 1.000 rs4675868 chr2:241828542 A/C cg04034577 chr2:241836375 C2orf54 -0.48 -8.18 -0.45 1.17e-14 Urinary metabolites; CESC cis rs914615 0.508 rs7535292 chr1:155127749 T/C cg02153340 chr1:155202674 NA -0.37 -5.51 -0.32 8.71e-8 Urinary albumin-to-creatinine ratio; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03991333 chr1:2458120 PANK4 -0.44 -6.11 -0.35 3.47e-9 Asthma; CESC cis rs763121 0.819 rs5757126 chr22:38923675 T/C cg06022373 chr22:39101656 GTPBP1 0.82 11.77 0.59 5.07e-26 Menopause (age at onset); CESC cis rs7927771 0.542 rs7102205 chr11:47745374 C/T cg18512352 chr11:47633146 NA 0.35 5.41 0.32 1.38e-7 Subjective well-being; CESC cis rs12541635 0.934 rs4734893 chr8:106990275 T/G cg10147462 chr8:107024639 NA 0.4 5.68 0.33 3.54e-8 Age of smoking initiation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10500953 chr16:346518 AXIN1 -0.67 -7.94 -0.44 5.94e-14 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg05368731 chr17:41323189 NBR1 0.75 10.35 0.54 2.72e-21 Menopause (age at onset); CESC cis rs7605827 0.780 rs2287278 chr2:15667771 C/G cg19274914 chr2:15703543 NA 0.38 6.68 0.38 1.38e-10 Educational attainment (years of education); CESC cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg12365402 chr11:9010492 NRIP3 0.34 5.3 0.31 2.42e-7 Hemoglobin concentration; CESC cis rs9443189 0.526 rs775060 chr6:76373567 G/A cg01950844 chr6:76311363 SENP6 -0.87 -9.27 -0.49 6.59e-18 Prostate cancer; CESC cis rs2463822 1.000 rs2513744 chr11:62077785 C/A cg06239285 chr11:62104954 ASRGL1 0.98 9.25 0.49 7.5e-18 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs13082711 0.911 rs4973769 chr3:27425746 T/C cg02860705 chr3:27208620 NA 0.52 6.53 0.37 3.36e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs992157 0.710 rs10169718 chr2:219103580 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.69 -9.77 -0.51 1.88e-19 Colorectal cancer; CESC cis rs1707322 1.000 rs10789479 chr1:46352500 T/C cg05343316 chr1:45956843 TESK2 0.49 5.96 0.34 7.98e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11098499 0.955 rs1511019 chr4:120166007 T/G cg24375607 chr4:120327624 NA 0.43 5.21 0.31 3.72e-7 Corneal astigmatism; CESC cis rs28437878 1 rs28437878 chr15:78807872 C/T cg06917634 chr15:78832804 PSMA4 -0.52 -5.71 -0.33 2.99e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.8 0.39 6.78e-11 Bipolar disorder; CESC cis rs763121 0.889 rs9607557 chr22:39040279 G/A cg06544989 chr22:39130855 UNC84B 0.52 9.57 0.51 7.89e-19 Menopause (age at onset); CESC cis rs1008375 1.000 rs2109522 chr4:17658645 T/A cg02297831 chr4:17616191 MED28 0.53 6.75 0.38 9.49e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg27121462 chr16:89883253 FANCA 0.59 7.64 0.42 4.1e-13 Vitiligo; CESC cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7144547 0.950 rs8004137 chr14:81884857 A/G cg23690444 chr14:81902736 NA 0.64 6.75 0.38 9.06e-11 Prudent dietary pattern; CESC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg14298792 chr15:30685198 CHRFAM7A -0.45 -5.36 -0.31 1.81e-7 Huntington's disease progression; CESC cis rs6754311 0.731 rs748841 chr2:136558157 C/T cg15123519 chr2:136567270 LCT 0.33 5.74 0.33 2.61e-8 Mosquito bite size; CESC cis rs7953249 0.807 rs7970695 chr12:121423376 G/A cg02403541 chr12:121454288 C12orf43 -0.51 -6.84 -0.39 5.58e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.48 0.81 2.38e-63 Prudent dietary pattern; CESC cis rs7267979 0.966 rs6083818 chr20:25346082 G/A cg08601574 chr20:25228251 PYGB -0.38 -5.46 -0.32 1.12e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs962856 0.592 rs6546296 chr2:67578422 A/G cg09028215 chr2:67624308 ETAA1 -0.44 -5.32 -0.31 2.2e-7 Pancreatic cancer; CESC cis rs7116495 0.881 rs598835 chr11:71797727 C/T cg10381502 chr11:71823885 C11orf51 -0.66 -5.4 -0.31 1.51e-7 Severe influenza A (H1N1) infection; CESC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg27170947 chr2:26402098 FAM59B -0.72 -8.31 -0.45 5.18e-15 Gut microbiome composition (summer); CESC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg19046167 chr17:80928561 B3GNTL1 -0.41 -5.03 -0.3 8.92e-7 Breast cancer; CESC cis rs9303401 0.573 rs34097494 chr17:57171917 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.88 11.1 0.56 8.94e-24 Cognitive test performance; CESC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.52 -0.37 3.57e-10 Bipolar disorder; CESC cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg00745463 chr17:30367425 LRRC37B -0.83 -7.54 -0.42 7.69e-13 Hip circumference adjusted for BMI; CESC trans rs35110281 0.627 rs11701746 chr21:44975137 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 7.11 0.4 1.1e-11 Mean corpuscular volume; CESC cis rs1797081 0.967 rs811912 chr10:16859618 G/C cg23933602 chr10:16859644 RSU1 1.14 24.21 0.83 4.13e-69 Platelet distribution width; CESC cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg10523679 chr1:76189770 ACADM 0.66 6.37 0.36 8.19e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7795096 0.806 rs10277655 chr7:151540697 T/C cg17008978 chr7:151542804 PRKAG2 0.39 7.25 0.41 4.53e-12 Bipolar disorder (age of onset and psychotic symptoms); CESC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.53 5.94 0.34 9.08e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10779751 0.690 rs743577 chr1:11119135 G/A cg08854313 chr1:11322531 MTOR 0.8 10.92 0.56 3.55e-23 Body mass index; CESC cis rs4917385 1 rs4917385 chr10:105003721 T/G cg04362960 chr10:104952993 NT5C2 0.47 5.56 0.32 6.45e-8 Systemic lupus erythematosus; CESC trans rs4904167 0.737 rs10873355 chr14:84681944 T/C cg06870609 chr15:89787223 FANCI 0.46 6.06 0.35 4.73e-9 Autism spectrum disorder or schizophrenia; CESC cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 7.66 0.43 3.61e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs854765 0.522 rs63721860 chr17:17829576 T/C cg04398451 chr17:18023971 MYO15A -0.71 -10.41 -0.54 1.66e-21 Total body bone mineral density; CESC cis rs9297145 0.724 rs6954584 chr7:98766930 G/A cg05967295 chr7:98741636 SMURF1 0.9 9.34 0.5 4.06e-18 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs9911578 1.000 rs9898916 chr17:57048660 C/T cg12560992 chr17:57184187 TRIM37 0.92 15.24 0.68 4.34e-38 Intelligence (multi-trait analysis); CESC cis rs3540 0.574 rs2526000 chr15:90962626 C/T cg22089800 chr15:90895588 ZNF774 0.6 7.96 0.44 4.96e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg11764359 chr7:65958608 NA 0.79 9.51 0.5 1.18e-18 Aortic root size; CESC cis rs2276314 0.857 rs28651028 chr18:33638910 G/A cg19628046 chr18:33552617 C18orf21 0.5 5.66 0.33 3.84e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.75 -0.33 2.42e-8 Total body bone mineral density; CESC cis rs55871839 0.708 rs7000535 chr8:59804351 T/C cg07426533 chr8:59803705 TOX -0.51 -7.39 -0.41 1.95e-12 Pneumonia; CESC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg12963246 chr6:28129442 ZNF389 0.57 7.78 0.43 1.65e-13 Depression; CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg23978390 chr7:1156363 C7orf50 0.5 6.79 0.38 7.43e-11 Longevity;Endometriosis; CESC cis rs6088590 0.965 rs13040449 chr20:33358901 T/A cg06115741 chr20:33292138 TP53INP2 0.63 7.77 0.43 1.77e-13 Coronary artery disease; CESC cis rs7980687 0.596 rs1727319 chr12:123701353 T/C cg05973401 chr12:123451056 ABCB9 0.46 5.67 0.33 3.65e-8 Height;Educational attainment;Head circumference (infant); CESC cis rs56104184 0.775 rs56349331 chr19:49403009 T/A cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10498100 chr11:121163245 SC5DL 0.52 6.0 0.35 6.37e-9 Gut microbiome composition (summer); CESC cis rs5758659 1.000 rs134902 chr22:42683997 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.28 -5.03 -0.3 8.85e-7 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10848882 chr20:39765963 PLCG1 0.56 6.55 0.37 3.02e-10 Gut microbiome composition (summer); CESC cis rs9649213 0.614 rs1006169 chr7:97938443 A/G cg09267113 chr7:98030324 BAIAP2L1 0.43 5.85 0.34 1.47e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7940866 0.903 rs7940465 chr11:130861339 C/T cg12179176 chr11:130786555 SNX19 0.63 9.11 0.49 2.05e-17 Schizophrenia; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg09379601 chr19:12992224 DNASE2 -0.47 -6.32 -0.36 1.13e-9 Height; CESC cis rs7223966 1.000 rs2854219 chr17:61942682 C/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.48 -5.4 -0.31 1.49e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg18350739 chr11:68623251 NA -0.45 -6.93 -0.39 3.15e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3825199 0.515 rs2072593 chr12:93970026 T/C cg18151635 chr12:93972918 NA -0.44 -5.89 -0.34 1.19e-8 Height; CESC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg12658694 chr1:38397304 INPP5B 0.64 9.33 0.5 4.39e-18 Coronary artery disease; CESC cis rs72781680 1.000 rs72781632 chr2:24198342 A/C cg08917208 chr2:24149416 ATAD2B 1.11 10.02 0.52 3.07e-20 Lymphocyte counts; CESC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg17971929 chr21:40555470 PSMG1 -0.55 -7.12 -0.4 1.01e-11 Menarche (age at onset); CESC cis rs9470366 0.816 rs1321311 chr6:36622900 C/A cg08179530 chr6:36648295 CDKN1A 0.55 6.59 0.38 2.41e-10 QRS duration; CESC cis rs897080 0.589 rs1085448 chr2:44663805 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.03 0.3 8.86e-7 Height; CESC cis rs17021463 0.902 rs34465979 chr4:95257554 C/A cg11021082 chr4:95130006 SMARCAD1 0.53 7.88 0.44 8.35e-14 Testicular germ cell tumor; CESC trans rs11722228 0.549 rs62288521 chr4:10099772 G/A cg26043149 chr18:55253948 FECH 0.92 10.86 0.55 5.93e-23 Gout;Urate levels;Serum uric acid levels; CESC cis rs9354308 0.899 rs2802055 chr6:66545756 T/C cg07460842 chr6:66804631 NA 0.57 6.4 0.37 6.89e-10 Metabolite levels; CESC trans rs61931739 0.534 rs1608911 chr12:34010249 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.21 0.45 9.45e-15 Morning vs. evening chronotype; CESC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg02931644 chr1:25747376 RHCE 0.47 8.18 0.45 1.17e-14 Erythrocyte sedimentation rate; CESC cis rs6736093 1.000 rs7349221 chr2:112668341 A/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.37 -0.31 1.72e-7 Coronary artery disease; CESC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg17376030 chr22:41985996 PMM1 -0.73 -7.85 -0.43 1e-13 Vitiligo; CESC cis rs7659604 0.628 rs6838153 chr4:122720999 A/G cg19748678 chr4:122722346 EXOSC9 0.76 9.57 0.51 7.84e-19 Type 2 diabetes; CESC cis rs7937682 0.562 rs630002 chr11:111377758 G/A cg22437258 chr11:111473054 SIK2 0.45 5.64 0.33 4.35e-8 Primary sclerosing cholangitis; CESC cis rs11122272 0.701 rs11122273 chr1:231476789 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.45 -6.48 -0.37 4.38e-10 Hemoglobin concentration; CESC trans rs629535 0.862 rs598548 chr8:70032438 C/T cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs910316 1.000 rs7142235 chr14:75559963 T/C cg11812906 chr14:75593930 NEK9 0.91 15.5 0.69 5.27e-39 Height; CESC cis rs10781543 0.776 rs11145760 chr9:139382594 G/A cg14019695 chr9:139328340 INPP5E 0.38 5.73 0.33 2.71e-8 Monocyte percentage of white cells; CESC cis rs9811920 0.638 rs793440 chr3:99643176 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.57 7.02 0.4 1.84e-11 Axial length; CESC cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg16262614 chr3:133464971 TF 0.43 8.6 0.47 7.12e-16 Iron status biomarkers (transferrin levels); CESC cis rs2953174 0.507 rs2953172 chr2:241525316 C/T cg03371404 chr2:241525653 CAPN10 -0.56 -6.0 -0.35 6.41e-9 Bipolar disorder; CESC cis rs897080 0.515 rs698818 chr2:44709769 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.37 0.31 1.72e-7 Height; CESC cis rs7301826 0.627 rs7978987 chr12:131281494 G/A cg11011512 chr12:131303247 STX2 -0.44 -5.36 -0.31 1.81e-7 Plasma plasminogen activator levels; CESC trans rs9419702 0.806 rs10872832 chr10:133531090 A/G cg22110973 chr15:91499626 RCCD1 -0.47 -6.23 -0.36 1.78e-9 Survival in rectal cancer; CESC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg21782813 chr7:2030301 MAD1L1 0.47 6.65 0.38 1.64e-10 Bipolar disorder and schizophrenia; CESC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg25036284 chr2:26402008 FAM59B -0.85 -9.25 -0.49 7.86e-18 Gut microbiome composition (summer); CESC cis rs6565180 1.000 rs11863150 chr16:30385503 C/T cg17640201 chr16:30407289 ZNF48 0.93 15.58 0.69 2.74e-39 Tonsillectomy; CESC cis rs8070128 0.600 rs8071238 chr17:17900990 T/C cg16928487 chr17:17741425 SREBF1 -0.5 -8.12 -0.45 1.77e-14 Total body bone mineral density; CESC cis rs6728642 1.000 rs7580504 chr2:97605597 C/G cg26665480 chr2:98280029 ACTR1B -0.75 -6.14 -0.35 3.08e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02872018 chr2:192746213 NA -0.42 -6.26 -0.36 1.51e-9 Gut microbiota (bacterial taxa); CESC cis rs4237845 0.591 rs10747788 chr12:58315338 C/T cg00677455 chr12:58241039 CTDSP2 0.54 6.42 0.37 6.15e-10 Intelligence (multi-trait analysis); CESC cis rs963731 0.522 rs4670907 chr2:39278066 C/T cg04010122 chr2:39346883 SOS1 -0.75 -5.66 -0.33 3.91e-8 Corticobasal degeneration; CESC cis rs4076764 0.801 rs6698738 chr1:163359918 G/A cg06092702 chr1:163392909 NA -0.37 -5.22 -0.31 3.65e-7 Motion sickness; CESC cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg20307385 chr11:47447363 PSMC3 -0.45 -5.41 -0.32 1.42e-7 Subjective well-being; CESC cis rs7084402 0.967 rs1623568 chr10:60320446 T/C cg07615347 chr10:60278583 BICC1 0.63 10.12 0.53 1.48e-20 Refractive error; CESC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg04369109 chr6:150039330 LATS1 -0.46 -6.31 -0.36 1.16e-9 Lung cancer; CESC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg23283495 chr1:209979779 IRF6 0.46 6.62 0.38 1.98e-10 Cleft lip with or without cleft palate; CESC cis rs3820928 0.904 rs6735069 chr2:227893660 A/G cg05526886 chr2:227700861 RHBDD1 -0.44 -5.47 -0.32 1.03e-7 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08187845 chr17:1420199 LOC100306951;INPP5K 0.61 6.94 0.39 3.08e-11 Gut microbiome composition (summer); CESC cis rs12478296 1.000 rs55732177 chr2:243040006 C/T cg06360820 chr2:242988706 NA -0.66 -7.52 -0.42 8.51e-13 Obesity-related traits; CESC cis rs7267979 1.000 rs2258617 chr20:25274318 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs7568458 0.709 rs11895399 chr2:85753806 C/A cg02493740 chr2:85810744 VAMP5 -0.57 -8.48 -0.46 1.57e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs2439831 0.850 rs524417 chr15:43772374 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.47 0.54 1.08e-21 Lung cancer in ever smokers; CESC cis rs17854409 1.000 rs16983290 chr20:61478894 A/G cg07645718 chr20:61493192 TCFL5 -0.83 -6.11 -0.35 3.45e-9 Obesity-related traits; CESC cis rs910316 0.699 rs175039 chr14:75468950 G/C cg08847533 chr14:75593920 NEK9 -0.87 -14.68 -0.67 4.1e-36 Height; CESC cis rs763121 0.853 rs2205802 chr22:39046327 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg25072359 chr17:41440525 NA 0.5 6.46 0.37 4.89e-10 Menopause (age at onset); CESC cis rs7267979 1.000 rs2387884 chr20:25379069 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.07 -0.74 4.08e-48 Liver enzyme levels (alkaline phosphatase); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23811096 chr1:33502772 AK2 -0.45 -6.11 -0.35 3.61e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs951366 0.538 rs56276813 chr1:205730573 G/T cg17178900 chr1:205818956 PM20D1 -0.41 -5.2 -0.3 4.06e-7 Menarche (age at onset); CESC cis rs28647808 1.000 rs35348753 chr9:136270070 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.91 5.71 0.33 3.03e-8 Blood protein levels; CESC cis rs7666738 0.578 rs1989109 chr4:98881246 T/A cg05340658 chr4:99064831 C4orf37 0.78 11.7 0.58 9.27e-26 Colonoscopy-negative controls vs population controls; CESC cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg18351406 chr4:77819688 ANKRD56 0.53 6.57 0.37 2.68e-10 Emphysema distribution in smoking; CESC trans rs11098499 0.775 rs2002049 chr4:120257417 A/G cg25214090 chr10:38739885 LOC399744 0.64 9.06 0.49 2.97e-17 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21454386 chr13:114292018 TFDP1 -0.68 -7.85 -0.43 1.04e-13 Gut microbiome composition (summer); CESC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg04166393 chr7:2884313 GNA12 -0.59 -7.62 -0.42 4.47e-13 Height; CESC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.38 0.54 2.06e-21 Prudent dietary pattern; CESC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg26408565 chr15:76604113 ETFA -0.4 -5.93 -0.34 9.44e-9 Blood metabolite levels; CESC cis rs155076 1.000 rs261406 chr13:21855854 G/A cg11317459 chr13:21872234 NA -1.06 -11.89 -0.59 1.99e-26 White matter hyperintensity burden; CESC cis rs28374715 0.662 rs111522288 chr15:41480169 C/T cg18705301 chr15:41695430 NDUFAF1 -0.79 -10.3 -0.53 3.96e-21 Ulcerative colitis; CESC cis rs1707322 1.000 rs1768800 chr1:46549188 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.57 -0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9309473 0.948 rs10173534 chr2:73813432 C/T cg20560298 chr2:73613845 ALMS1 -0.54 -7.25 -0.41 4.47e-12 Metabolite levels; CESC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg25517755 chr10:38738941 LOC399744 -0.49 -6.35 -0.36 9.09e-10 Extrinsic epigenetic age acceleration; CESC cis rs9549367 0.789 rs9549708 chr13:113891887 A/G cg18105134 chr13:113819100 PROZ -0.66 -7.93 -0.44 6.05e-14 Platelet distribution width; CESC cis rs9467711 0.720 rs9348716 chr6:26375658 G/A cg12826209 chr6:26865740 GUSBL1 0.64 5.25 0.31 3.2e-7 Autism spectrum disorder or schizophrenia; CESC cis rs3741151 1.000 rs7949364 chr11:73041077 A/G cg17517138 chr11:73019481 ARHGEF17 0.63 5.25 0.31 3.19e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg08736216 chr1:53307985 ZYG11A 0.37 5.99 0.35 6.8e-9 Monocyte count; CESC cis rs6831352 0.918 rs29001209 chr4:100052340 C/A cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg08499158 chr17:42289980 UBTF -0.5 -6.32 -0.36 1.1e-9 Total body bone mineral density; CESC cis rs909002 0.819 rs4949457 chr1:32140053 C/T cg13919466 chr1:32135498 COL16A1 0.39 6.09 0.35 3.87e-9 Intelligence (multi-trait analysis); CESC cis rs1707322 0.827 rs10890347 chr1:46242332 A/T cg05343316 chr1:45956843 TESK2 -0.48 -5.8 -0.34 1.86e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7809950 0.678 rs7788271 chr7:106985873 A/G cg23024343 chr7:107201750 COG5 -0.52 -6.73 -0.38 1.02e-10 Coronary artery disease; CESC cis rs4919087 0.810 rs1468069 chr10:98988759 A/C cg25902810 chr10:99078978 FRAT1 0.61 8.33 0.46 4.42e-15 Monocyte count; CESC cis rs8141529 0.719 rs5762825 chr22:29223642 A/G cg02153584 chr22:29168773 CCDC117 0.64 9.16 0.49 1.46e-17 Lymphocyte counts; CESC cis rs3916 0.955 rs12828810 chr12:121152017 T/G cg21892295 chr12:121157589 UNC119B -0.36 -5.23 -0.31 3.47e-7 Urinary metabolites (H-NMR features); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg27138088 chr11:842605 TSPAN4;POLR2L 0.52 6.87 0.39 4.62e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs10870270 1.000 rs4880246 chr10:133764064 C/T cg17892150 chr10:133769511 PPP2R2D -0.87 -12.78 -0.62 1.87e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs6502050 0.871 rs62079998 chr17:80077245 A/C cg11859384 chr17:80120422 CCDC57 0.41 5.62 0.33 4.75e-8 Life satisfaction; CESC cis rs8014204 0.967 rs2359240 chr14:75328247 T/C cg08847533 chr14:75593920 NEK9 -0.47 -5.81 -0.34 1.79e-8 Caffeine consumption; CESC cis rs6580649 0.941 rs60681522 chr12:48464195 T/C cg05342945 chr12:48394962 COL2A1 0.51 5.91 0.34 1.07e-8 Lung cancer; CESC cis rs4803468 1.000 rs284658 chr19:41929988 G/A cg14132834 chr19:41945861 ATP5SL -0.58 -7.12 -0.4 9.92e-12 Height; CESC cis rs17376456 0.877 rs34673483 chr5:93315079 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.65 5.62 0.33 4.95e-8 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01023808 chr7:97857492 TECPR1 -0.57 -6.65 -0.38 1.66e-10 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs28595532 0.668 rs56410164 chr4:119331625 A/G cg21605333 chr4:119757512 SEC24D 1.01 5.58 0.32 5.87e-8 Cannabis dependence symptom count; CESC cis rs7246657 0.943 rs28373708 chr19:37976659 C/T cg23950597 chr19:37808831 NA -0.58 -6.39 -0.37 7.52e-10 Coronary artery calcification; CESC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg22903657 chr4:1355424 KIAA1530 -0.37 -5.13 -0.3 5.63e-7 Obesity-related traits; CESC cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg05340658 chr4:99064831 C4orf37 0.76 11.26 0.57 2.63e-24 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.603 rs4506967 chr17:17990474 A/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 5.96 0.34 8.22e-9 Total body bone mineral density; CESC cis rs7560272 0.695 rs780393 chr2:73701669 T/A cg20560298 chr2:73613845 ALMS1 0.5 7.15 0.4 8.3e-12 Schizophrenia; CESC cis rs2014572 0.967 rs7248000 chr19:57762139 C/T cg12963866 chr19:57752005 ZNF805 -0.49 -6.6 -0.38 2.28e-10 Hyperactive-impulsive symptoms; CESC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.62 0.33 4.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg17949981 chr6:28129498 ZNF389 0.42 5.23 0.31 3.39e-7 Depression; CESC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg13628971 chr7:2884303 GNA12 0.62 8.11 0.45 1.84e-14 Height; CESC cis rs6922893 1.000 rs6455393 chr6:71681558 A/G cg10766373 chr6:71666121 B3GAT2 -0.34 -5.29 -0.31 2.56e-7 Obesity-related traits; CESC cis rs798766 1.000 rs798767 chr4:1734281 A/G cg05874882 chr4:1763078 NA -0.59 -7.71 -0.43 2.5e-13 Bladder cancer;Urinary bladder cancer; CESC cis rs7044106 0.537 rs4434680 chr9:123489688 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 9.65 0.51 4.31e-19 Hip circumference adjusted for BMI; CESC cis rs5758659 0.622 rs6519298 chr22:42364997 C/T cg19513890 chr22:42538836 CYP2D7P1 -0.36 -5.13 -0.3 5.73e-7 Cognitive function; CESC cis rs2204008 0.687 rs2320523 chr12:38251397 T/C cg26384229 chr12:38710491 ALG10B 0.65 9.03 0.49 3.55e-17 Bladder cancer; CESC cis rs1355223 0.752 rs286893 chr11:34674882 C/G cg11058730 chr11:34937778 PDHX;APIP 0.5 6.51 0.37 3.67e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg04944784 chr2:26401820 FAM59B -0.67 -7.65 -0.43 3.71e-13 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.13 0.53 1.3e-20 Prudent dietary pattern; CESC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.6 0.38 2.23e-10 Prudent dietary pattern; CESC cis rs9814567 0.964 rs1534028 chr3:134284639 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.05 -0.35 4.79e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2979489 0.891 rs4537262 chr8:30306757 T/A cg26383811 chr8:30366931 RBPMS 0.84 9.92 0.52 6.18e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs7762018 1.000 rs6459657 chr6:170136454 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.61 6.2 0.36 2.12e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6582630 0.519 rs11520262 chr12:38333051 A/G cg26384229 chr12:38710491 ALG10B 0.73 10.9 0.56 4.29e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs8017423 0.967 rs2277517 chr14:90722778 G/A cg14092571 chr14:90743983 NA -0.55 -8.31 -0.45 5.06e-15 Mortality in heart failure; CESC cis rs1707322 0.686 rs2991987 chr1:46081422 C/G cg03146154 chr1:46216737 IPP -0.81 -11.13 -0.56 7.28e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs28493229 0.522 rs2233152 chr19:41281016 C/T cg21869046 chr19:41225005 ITPKC 0.49 6.39 0.37 7.49e-10 Kawasaki disease; CESC cis rs10751667 1.000 rs10794349 chr11:945678 T/C cg06064525 chr11:970664 AP2A2 -0.42 -7.63 -0.42 4.21e-13 Alzheimer's disease (late onset); CESC cis rs34779708 0.966 rs11010095 chr10:35395948 A/G cg03585969 chr10:35415529 CREM 0.78 10.17 0.53 1e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.34 -5.4 -0.31 1.5e-7 Monocyte percentage of white cells; CESC cis rs933688 1.000 rs7720132 chr5:90745105 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 13.7 0.64 1.17e-32 Smoking behavior; CESC cis rs7312933 0.558 rs1796384 chr12:42780568 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.51 -6.73 -0.38 1.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs2742417 1.000 rs2742432 chr3:45737467 G/T cg10512202 chr3:45649293 LIMD1 0.35 5.06 0.3 7.85e-7 Response to anti-depressant treatment in major depressive disorder; CESC cis rs7592578 0.766 rs12472081 chr2:191398545 G/A cg10560079 chr2:191398806 TMEM194B -0.63 -5.32 -0.31 2.21e-7 Diastolic blood pressure; CESC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Parkinson's disease; CESC cis rs3126085 0.935 rs10888473 chr1:152220235 G/A cg03465714 chr1:152285911 FLG -0.44 -5.34 -0.31 1.96e-7 Atopic dermatitis; CESC cis rs2599510 0.744 rs4952212 chr2:32618493 G/C cg02381751 chr2:32503542 YIPF4 -0.49 -6.21 -0.36 1.99e-9 Interleukin-18 levels; CESC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg13047869 chr3:10149882 C3orf24 0.4 5.03 0.3 8.89e-7 Alzheimer's disease; CESC cis rs7582720 1.000 rs72928609 chr2:203837573 G/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs1843834 0.898 rs12623277 chr2:225548072 T/G cg22455342 chr2:225449267 CUL3 0.51 6.55 0.37 3.01e-10 IgE levels in asthmatics (D.p. specific); CESC trans rs4376189 0.681 rs13136101 chr4:186624184 G/A cg21381065 chr18:49866304 DCC -0.4 -6.29 -0.36 1.34e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs854765 0.520 rs7219324 chr17:17909775 C/T cg04398451 chr17:18023971 MYO15A 0.6 8.23 0.45 8.57e-15 Total body bone mineral density; CESC cis rs10791097 0.609 rs3751039 chr11:130773076 A/G cg14779329 chr11:130786720 SNX19 -0.33 -5.32 -0.31 2.19e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs758324 0.898 rs11958749 chr5:131166014 T/C cg06307176 chr5:131281290 NA 0.42 5.04 0.3 8.69e-7 Alzheimer's disease in APOE e4- carriers; CESC cis rs4454254 1.000 rs4454254 chr8:141060027 C/T cg06693505 chr8:141057453 TRAPPC9 -0.32 -5.17 -0.3 4.53e-7 Pulse pressure; CESC cis rs17092148 0.636 rs6058107 chr20:33288546 T/C cg24642439 chr20:33292090 TP53INP2 0.5 5.21 0.31 3.72e-7 Neuroticism; CESC cis rs9325144 0.671 rs35817541 chr12:38975001 T/C cg26384229 chr12:38710491 ALG10B -0.53 -7.38 -0.41 2.09e-12 Morning vs. evening chronotype; CESC cis rs3736485 0.932 rs4775946 chr15:51775930 A/G cg08986416 chr15:51914746 DMXL2 -0.42 -5.54 -0.32 7.22e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg08736216 chr1:53307985 ZYG11A 0.32 5.66 0.33 4e-8 Monocyte count; CESC cis rs11969893 0.649 rs1321204 chr6:101468591 A/G cg12253828 chr6:101329408 ASCC3 0.63 5.15 0.3 4.97e-7 Economic and political preferences (immigration/crime); CESC cis rs3749237 0.595 rs885592 chr3:49497883 T/G cg07636037 chr3:49044803 WDR6 0.61 8.86 0.48 1.19e-16 Resting heart rate; CESC cis rs2688608 0.592 rs11000759 chr10:75493726 G/A cg23231163 chr10:75533350 FUT11 -0.36 -5.42 -0.32 1.36e-7 Inflammatory bowel disease; CESC trans rs61931739 0.620 rs708143 chr12:33719962 A/C cg26384229 chr12:38710491 ALG10B 0.55 8.21 0.45 9.66e-15 Morning vs. evening chronotype; CESC cis rs847577 0.515 rs10953238 chr7:97676259 C/T cg21770322 chr7:97807741 LMTK2 0.79 13.74 0.64 8.64e-33 Breast cancer; CESC cis rs7923452 0.688 rs117895480 chr10:30788921 A/G cg18806716 chr10:30721971 MAP3K8 0.46 5.61 0.33 5.02e-8 Itch intensity from mosquito bite; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05617300 chr19:59093449 MGC2752 0.47 6.26 0.36 1.55e-9 Fibrinogen levels; CESC cis rs2425143 1.000 rs73902908 chr20:34365112 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.69 5.95 0.34 8.54e-9 Blood protein levels; CESC cis rs116095464 0.558 rs57335027 chr5:262907 A/G cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.51e-10 Breast cancer; CESC cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg27121462 chr16:89883253 FANCA -0.55 -6.87 -0.39 4.44e-11 Vitiligo; CESC cis rs17253792 0.731 rs28587929 chr14:56097492 C/T cg01858014 chr14:56050164 KTN1 -0.83 -7.03 -0.4 1.7e-11 Putamen volume; CESC cis rs2952156 0.920 rs14050 chr17:37828072 C/T cg07936489 chr17:37558343 FBXL20 -0.55 -6.84 -0.39 5.53e-11 Asthma; CESC cis rs2124969 0.527 rs56040145 chr2:160983850 A/G cg03641300 chr2:160917029 PLA2R1 -0.56 -5.77 -0.33 2.19e-8 Waist circumference adjusted for body mass index; CESC cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg12365402 chr11:9010492 NRIP3 -0.46 -7.82 -0.43 1.23e-13 Hemoglobin concentration; CESC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.95 0.52 5.14e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9916302 0.904 rs11078898 chr17:37536480 A/G cg20243544 chr17:37824526 PNMT -0.51 -6.43 -0.37 5.87e-10 Glomerular filtration rate (creatinine); CESC cis rs9549367 0.789 rs34568744 chr13:113894564 G/T cg18105134 chr13:113819100 PROZ -0.66 -7.97 -0.44 4.85e-14 Platelet distribution width; CESC cis rs568617 0.953 rs658938 chr11:65651830 A/G cg19792802 chr11:65647270 CTSW -0.35 -5.31 -0.31 2.33e-7 Crohn's disease; CESC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg19717773 chr7:2847554 GNA12 -0.52 -7.42 -0.41 1.57e-12 Height; CESC cis rs116095464 0.614 rs78905930 chr5:246560 G/A cg10591111 chr5:226296 SDHA -0.51 -6.17 -0.35 2.49e-9 Breast cancer; CESC cis rs1832871 0.672 rs56115227 chr6:158773884 G/A cg07165851 chr6:158734300 TULP4 0.59 6.35 0.36 9.19e-10 Height; CESC cis rs7568458 0.709 rs1446669 chr2:85762209 T/C cg02493740 chr2:85810744 VAMP5 -0.58 -8.52 -0.46 1.19e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg22508957 chr16:3507546 NAT15 0.54 8.53 0.46 1.11e-15 Tuberculosis; CESC cis rs17376456 0.569 rs10057664 chr5:93182274 C/T cg25358565 chr5:93447407 FAM172A -0.71 -7.64 -0.43 3.86e-13 Diabetic retinopathy; CESC cis rs4268898 0.662 rs12052954 chr2:24425620 C/T cg06627628 chr2:24431161 ITSN2 0.94 10.38 0.54 2.18e-21 Asthma; CESC cis rs950169 0.649 rs12905952 chr15:84691261 G/A cg17507749 chr15:85114479 UBE2QP1 0.58 5.77 0.33 2.21e-8 Schizophrenia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12623088 chr15:66585521 DIS3L -0.49 -6.21 -0.36 2.06e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg14196790 chr5:131705035 SLC22A5 -0.34 -5.1 -0.3 6.5e-7 Blood metabolite levels; CESC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.35 -5.7 -0.33 3.13e-8 Bipolar disorder; CESC cis rs634534 0.563 rs470192 chr11:65724291 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.65 0.38 1.71e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs2599510 0.755 rs67257914 chr2:32804018 G/A cg02381751 chr2:32503542 YIPF4 0.45 5.46 0.32 1.1e-7 Interleukin-18 levels; CESC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg27266027 chr21:40555129 PSMG1 0.43 5.13 0.3 5.5e-7 Cognitive function; CESC cis rs2243480 1.000 rs7787230 chr7:65629099 G/A cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.25e-32 Diabetic kidney disease; CESC cis rs11190604 0.832 rs2489041 chr10:102333635 G/C cg07080220 chr10:102295463 HIF1AN 0.64 5.4 0.31 1.5e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg05025164 chr4:1340916 KIAA1530 0.86 11.74 0.59 6.48e-26 Longevity; CESC cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg11366901 chr6:160182831 ACAT2 0.78 9.48 0.5 1.56e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg20891283 chr12:69753455 YEATS4 0.9 14.78 0.67 1.84e-36 Blood protein levels; CESC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13470919 chr12:108955320 ISCU;SART3 -0.54 -6.56 -0.37 2.77e-10 Gut microbiome composition (summer); CESC cis rs9467711 0.606 rs9379852 chr6:26357278 A/G cg14345882 chr6:26364793 BTN3A2 0.59 6.06 0.35 4.66e-9 Autism spectrum disorder or schizophrenia; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg04297258 chr16:88772664 RNF166;CTU2 0.61 6.14 0.35 2.94e-9 Diastolic blood pressure; CESC cis rs6736093 0.700 rs4848958 chr2:112785775 T/C cg12686935 chr2:112915763 FBLN7 -0.4 -5.49 -0.32 9.27e-8 Coronary artery disease; CESC cis rs6499255 0.951 rs2361838 chr16:69676086 T/C cg15192750 chr16:69999425 NA 0.46 5.34 0.31 2.04e-7 IgE levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12926404 chr11:72145533 CLPB 0.57 6.57 0.37 2.6200000000000003e-10 Gut microbiome composition (summer); CESC cis rs9487051 0.676 rs9398193 chr6:109593134 G/T cg21918786 chr6:109611834 NA -0.37 -5.41 -0.32 1.39e-7 Reticulocyte fraction of red cells; CESC cis rs763121 0.853 rs3788545 chr22:39065172 A/G cg21395723 chr22:39101663 GTPBP1 0.43 5.36 0.31 1.77e-7 Menopause (age at onset); CESC cis rs10979 1.000 rs9390112 chr6:143896147 G/A cg25407410 chr6:143891975 LOC285740 -0.58 -8.64 -0.47 5.28e-16 Hypospadias; CESC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 5.35 0.31 1.94e-7 Tonsillectomy; CESC cis rs7855088 1.000 rs7855077 chr9:100742225 C/T cg13688889 chr9:100608707 NA -0.37 -5.52 -0.32 8.28e-8 Serum thyroid-stimulating hormone levels; CESC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.36 0.31 1.85e-7 Bipolar disorder; CESC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg13607699 chr17:42295918 UBTF 0.56 7.08 0.4 1.31e-11 Total body bone mineral density; CESC cis rs28374715 0.662 rs113913466 chr15:41483100 A/G cg18705301 chr15:41695430 NDUFAF1 -0.8 -10.46 -0.54 1.15e-21 Ulcerative colitis; CESC cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs9660992 0.710 rs1172138 chr1:205246019 G/A cg21643547 chr1:205240462 TMCC2 -0.46 -6.16 -0.35 2.74e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg11890956 chr21:40555474 PSMG1 -0.61 -8.26 -0.45 7.14e-15 Menarche (age at onset); CESC cis rs17818399 1.000 rs62136864 chr2:46829124 G/A cg02822958 chr2:46747628 ATP6V1E2 0.47 5.85 0.34 1.42e-8 Height; CESC cis rs113835537 0.569 rs17496586 chr11:66315512 G/C cg22134325 chr11:66188745 NPAS4 0.46 6.79 0.38 7.33e-11 Airway imaging phenotypes; CESC cis rs7829975 0.714 rs11777085 chr8:8672429 G/C cg15556689 chr8:8085844 FLJ10661 0.44 5.55 0.32 6.91e-8 Mood instability; CESC trans rs724568 0.521 rs1430760 chr2:67947592 C/T cg19718508 chr5:176831858 F12 -0.48 -6.03 -0.35 5.37e-9 Major depressive disorder (broad); CESC cis rs6580649 0.941 rs72644841 chr12:48411987 A/G cg05342945 chr12:48394962 COL2A1 0.49 5.64 0.33 4.44e-8 Lung cancer; CESC cis rs2070997 0.756 rs3134875 chr9:133710072 G/C cg11464064 chr9:133710261 ABL1 0.58 5.74 0.33 2.59e-8 Response to amphetamines; CESC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg08470875 chr2:26401718 FAM59B -0.52 -5.8 -0.34 1.93e-8 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs1800331 chr16:89858417 C/A cg04013166 chr16:89971882 TCF25 0.77 6.61 0.38 2.05e-10 Skin colour saturation; CESC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.02 0.4 1.91e-11 Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14064766 chr2:239344455 ASB1 -0.46 -6.03 -0.35 5.5e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs67311347 0.577 rs2371129 chr3:40248393 C/T cg09455208 chr3:40491958 NA -0.36 -5.74 -0.33 2.52e-8 Renal cell carcinoma; CESC cis rs12579753 1.000 rs2400979 chr12:82197353 T/C cg24719984 chr12:82153464 PPFIA2 -0.36 -5.07 -0.3 7.59e-7 Resting heart rate; CESC cis rs3820068 0.581 rs16851876 chr1:15950628 A/T cg17385448 chr1:15911702 AGMAT -0.41 -6.68 -0.38 1.4e-10 Systolic blood pressure; CESC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg03264133 chr6:25882463 NA 0.47 6.69 0.38 1.32e-10 Intelligence (multi-trait analysis); CESC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg23758822 chr17:41437982 NA 0.99 16.77 0.72 1.6700000000000001e-43 Menopause (age at onset); CESC cis rs7927592 0.731 rs11228275 chr11:68303980 G/A cg01657329 chr11:68192670 LRP5 0.48 6.6 0.38 2.19e-10 Total body bone mineral density; CESC cis rs9913156 0.748 rs55959711 chr17:4562581 C/A cg00122941 chr17:4613640 ARRB2 0.85 9.99 0.52 3.79e-20 Lymphocyte counts; CESC cis rs13108904 0.870 rs3775092 chr4:1240962 C/G cg00684032 chr4:1343700 KIAA1530 0.39 5.51 0.32 8.54e-8 Obesity-related traits; CESC cis rs1559088 0.948 rs7247748 chr19:33594023 T/C cg17764715 chr19:33622953 WDR88 0.49 6.45 0.37 5.37e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs854765 0.583 rs7503334 chr17:17779458 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.49 -6.26 -0.36 1.58e-9 Total body bone mineral density; CESC cis rs12190007 0.846 rs9505962 chr6:169726667 A/G cg16388071 chr6:169726476 NA 0.43 6.06 0.35 4.69e-9 Obesity-related traits; CESC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.47 -0.32 1.06e-7 Aortic root size; CESC cis rs9303280 0.806 rs12232498 chr17:38040363 T/C cg20243544 chr17:37824526 PNMT 0.5 6.54 0.37 3.21e-10 Self-reported allergy; CESC cis rs1912483 0.505 rs3760372 chr17:45380002 T/C cg25173405 chr17:45401733 C17orf57 -0.5 -5.78 -0.33 2.09e-8 Coronary artery disease; CESC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg06453172 chr10:134556979 INPP5A -0.39 -5.08 -0.3 7.01e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg11301795 chr4:187892539 NA -0.74 -11.49 -0.58 4.63e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs2625529 0.652 rs1481862 chr15:72245648 G/A cg16672083 chr15:72433130 SENP8 0.4 6.1 0.35 3.78e-9 Red blood cell count; CESC cis rs9324022 0.790 rs56011271 chr14:101167732 C/T cg18089426 chr14:101175970 NA 0.56 5.88 0.34 1.25e-8 Plateletcrit; CESC cis rs12586317 0.620 rs2295104 chr14:35579927 A/G cg16230307 chr14:35515116 FAM177A1 -0.83 -9.13 -0.49 1.76e-17 Psoriasis; CESC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.2 -0.3 3.97e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs11098499 0.954 rs11722872 chr4:120233030 G/C cg25214090 chr10:38739885 LOC399744 0.7 9.63 0.51 5.2e-19 Corneal astigmatism; CESC cis rs1707322 0.752 rs11211171 chr1:46168642 A/G cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12973672 1.000 rs12975284 chr19:35770962 G/C cg12095397 chr19:35769544 USF2 0.54 7.35 0.41 2.49e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs35306767 0.714 rs67696450 chr10:1090684 C/T cg26597838 chr10:835615 NA 0.63 5.95 0.34 8.67e-9 Eosinophil percentage of granulocytes; CESC cis rs9487051 0.676 rs7775206 chr6:109597222 A/G cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs6740322 1.000 rs11693666 chr2:43562479 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.59 6.65 0.38 1.66e-10 Coronary artery disease; CESC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.88 0.39 4.18e-11 Bipolar disorder; CESC cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg25019033 chr10:957182 NA -0.6 -5.9 -0.34 1.14e-8 Eosinophil percentage of granulocytes; CESC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg14159672 chr1:205819179 PM20D1 0.48 6.78 0.38 7.83e-11 Prostate cancer; CESC cis rs2228479 0.717 rs34027607 chr16:89808939 T/C cg04287289 chr16:89883240 FANCA 0.71 6.53 0.37 3.42e-10 Skin colour saturation; CESC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg11764359 chr7:65958608 NA -0.79 -12.0 -0.59 9.01e-27 Aortic root size; CESC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg00310523 chr12:86230176 RASSF9 0.43 6.48 0.37 4.4e-10 Major depressive disorder; CESC cis rs67478160 0.643 rs11626377 chr14:104234357 G/A cg08213375 chr14:104286397 PPP1R13B 0.55 11.09 0.56 9.71e-24 Schizophrenia; CESC trans rs2727020 0.681 rs2866362 chr11:49379316 A/G cg15704280 chr7:45808275 SEPT13 -0.87 -14.48 -0.66 2.03e-35 Coronary artery disease; CESC cis rs3815700 0.920 rs10426856 chr19:33096406 A/G cg24916020 chr19:33096688 ANKRD27 0.61 6.1 0.35 3.64e-9 Eosinophilic esophagitis; CESC trans rs4950322 0.570 rs79810882 chr1:146707223 G/T cg04954894 chr8:38089920 DDHD2 -0.59 -6.17 -0.35 2.59e-9 Protein quantitative trait loci; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13171016 chr1:40219054 PPIE -0.65 -7.86 -0.43 9.72e-14 Gut microbiome composition (summer); CESC cis rs344364 0.511 rs1742472 chr16:1953040 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.52 -5.87 -0.34 1.29e-8 Glomerular filtration rate in chronic kidney disease; CESC cis rs7267979 1.000 rs2258769 chr20:25276680 G/C cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs3091242 0.933 rs35148262 chr1:25766623 A/G cg03538708 chr1:25844672 NA -0.42 -6.34 -0.36 9.58e-10 Erythrocyte sedimentation rate; CESC cis rs2732480 0.557 rs2732454 chr12:48719677 T/C cg04545296 chr12:48745243 ZNF641 0.36 6.27 0.36 1.49e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg00475322 chr7:917719 C7orf20 0.44 6.49 0.37 4.2e-10 Perceived unattractiveness to mosquitoes; CESC cis rs10791323 0.569 rs5019134 chr11:133713082 G/C cg15485101 chr11:133734466 NA 0.4 6.59 0.38 2.34e-10 Childhood ear infection; CESC cis rs9611565 0.694 rs5751107 chr22:41857812 A/G cg17376030 chr22:41985996 PMM1 -0.74 -7.87 -0.44 9.15e-14 Vitiligo; CESC cis rs9287719 0.967 rs6432119 chr2:10753687 A/T cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs6570726 0.935 rs387965 chr6:145869366 A/G cg23711669 chr6:146136114 FBXO30 0.78 11.34 0.57 1.42e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs7809950 1.000 rs7778270 chr7:107224667 A/G cg23024343 chr7:107201750 COG5 0.4 5.58 0.32 5.8e-8 Coronary artery disease; CESC cis rs4472734 0.932 rs6540833 chr1:214627389 T/G cg00063699 chr1:214624242 PTPN14 -0.33 -5.05 -0.3 8.33e-7 Height; CESC cis rs6860806 0.531 rs274556 chr5:131722075 A/G cg24060327 chr5:131705240 SLC22A5 0.77 10.88 0.56 4.95e-23 Breast cancer; CESC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg05457628 chr5:178986728 RUFY1 0.54 8.23 0.45 8.35e-15 Lung cancer; CESC cis rs7520050 0.931 rs785472 chr1:46518288 T/A cg03146154 chr1:46216737 IPP -0.44 -5.72 -0.33 2.88e-8 Red blood cell count;Reticulocyte count; CESC cis rs858239 0.539 rs6955726 chr7:23186691 A/G cg23682824 chr7:23144976 KLHL7 0.5 6.58 0.37 2.5e-10 Cerebrospinal fluid biomarker levels; CESC cis rs3892630 0.878 rs7246451 chr19:33209614 C/G cg22980127 chr19:33182716 NUDT19 1.06 11.32 0.57 1.71e-24 Red blood cell traits; CESC cis rs763121 0.819 rs5750658 chr22:39060917 C/T cg21395723 chr22:39101663 GTPBP1 0.43 5.37 0.31 1.74e-7 Menopause (age at onset); CESC cis rs2952156 0.920 rs732083 chr17:37834367 G/A cg20243544 chr17:37824526 PNMT 0.62 8.34 0.46 4.13e-15 Asthma; CESC cis rs11583043 0.546 rs6688545 chr1:101590335 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 5.43 0.32 1.28e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs17376456 0.877 rs10055340 chr5:93317644 T/C cg25358565 chr5:93447407 FAM172A 1.07 10.7 0.55 1.86e-22 Diabetic retinopathy; CESC cis rs2243480 1.000 rs313807 chr7:65499481 C/T cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.77 0.33 2.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Parkinson's disease; CESC cis rs362272 0.505 rs60208975 chr4:3364530 A/G cg14583973 chr4:3374767 RGS12 0.32 5.57 0.32 6.25e-8 Serum sulfate level; CESC cis rs12476592 0.602 rs2166497 chr2:63800159 C/T cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs9399137 0.507 rs13209780 chr6:135344795 G/C cg24558204 chr6:135376177 HBS1L 0.7 9.93 0.52 5.68e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs6456156 0.528 rs6936261 chr6:167469676 A/C cg23791538 chr6:167370224 RNASET2 -0.52 -6.73 -0.38 1.06e-10 Primary biliary cholangitis; CESC cis rs7927771 0.524 rs4752798 chr11:47886364 T/C cg18512352 chr11:47633146 NA -0.36 -5.57 -0.32 6.3e-8 Subjective well-being; CESC cis rs9910055 0.529 rs228748 chr17:42174390 G/A cg13607699 chr17:42295918 UBTF -0.55 -7.05 -0.4 1.58e-11 Total body bone mineral density; CESC cis rs8141529 0.956 rs469989 chr22:29303595 G/C cg15103426 chr22:29168792 CCDC117 -0.53 -6.29 -0.36 1.34e-9 Lymphocyte counts; CESC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.37 -0.31 1.76e-7 Life satisfaction; CESC cis rs5769765 0.728 rs6520064 chr22:50294469 A/G cg02269571 chr22:50332266 NA -0.45 -6.03 -0.35 5.63e-9 Schizophrenia; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09219196 chr12:53901441 NPFF -0.45 -6.25 -0.36 1.6e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2731664 0.792 rs385981 chr5:176886539 C/T cg23176889 chr5:176863531 GRK6 -0.62 -10.96 -0.56 2.64e-23 Intelligence (multi-trait analysis); CESC cis rs2290159 0.571 rs7637392 chr3:12696433 A/G cg23032965 chr3:12705835 RAF1 0.53 5.7 0.33 3.12e-8 Cholesterol, total; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20650035 chr12:29542837 NA -0.45 -6.36 -0.36 8.68e-10 Gut microbiota (bacterial taxa); CESC cis rs11098499 0.697 rs10020027 chr4:120381879 G/C cg24375607 chr4:120327624 NA 0.44 5.51 0.32 8.65e-8 Corneal astigmatism; CESC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg00129232 chr17:37814104 STARD3 -0.51 -6.41 -0.37 6.79e-10 Urinary metabolites; CESC cis rs4148883 0.713 rs3828541 chr4:100042262 A/G cg12011299 chr4:100065546 ADH4 0.66 9.79 0.52 1.56e-19 Alcohol dependence; CESC cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.95 8.85 0.48 1.3e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs708547 0.871 rs2687238 chr4:57880474 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 7.91 0.44 6.86e-14 Response to bleomycin (chromatid breaks); CESC cis rs738322 0.839 rs9607517 chr22:38596100 G/A cg17652424 chr22:38574118 PLA2G6 0.3 5.21 0.3 3.84e-7 Cutaneous nevi; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11053272 chr21:42540868 BACE2 0.56 6.0 0.35 6.31e-9 Gut microbiome composition (summer); CESC cis rs796364 0.806 rs1509832 chr2:200874443 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 7.76 0.43 1.81e-13 Schizophrenia; CESC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg27535305 chr1:53392650 SCP2 0.35 6.19 0.36 2.25e-9 Monocyte count; CESC cis rs9309473 0.519 rs6730785 chr2:73642403 A/C cg20560298 chr2:73613845 ALMS1 0.48 6.82 0.39 6.22e-11 Metabolite levels; CESC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg21782813 chr7:2030301 MAD1L1 0.46 6.45 0.37 5.27e-10 Bipolar disorder and schizophrenia; CESC cis rs11711311 0.955 rs12636536 chr3:113474226 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.04 0.52 2.67e-20 IgG glycosylation; CESC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg26335602 chr6:28129616 ZNF389 0.38 5.53 0.32 7.72e-8 Cardiac Troponin-T levels; CESC cis rs7909074 0.899 rs2026428 chr10:45389452 T/C cg05187965 chr10:45406764 TMEM72 -0.33 -5.06 -0.3 7.83e-7 Mean corpuscular volume; CESC cis rs2295499 0.673 rs4690016 chr4:2707132 G/A cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.24 -0.31 3.34e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs7385804 0.766 rs1734909 chr7:100309582 C/G cg20848291 chr7:100343083 ZAN 0.48 6.46 0.37 5.08e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg24531977 chr5:56204891 C5orf35 -0.88 -11.52 -0.58 3.54e-25 Initial pursuit acceleration; CESC cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg03433033 chr1:76189801 ACADM 0.59 5.78 0.33 2.13e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg24531977 chr5:56204891 C5orf35 -0.82 -11.08 -0.56 1.05e-23 Initial pursuit acceleration; CESC cis rs1580019 0.961 rs4320456 chr7:32496003 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.15 0.53 1.14e-20 Cognitive ability; CESC cis rs7267979 1.000 rs2258563 chr20:25273435 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.66 0.75 3.33e-50 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03092607 chr2:96068514 FAHD2A 0.52 6.23 0.36 1.87e-9 Gut microbiome composition (summer); CESC cis rs977987 0.806 rs4888386 chr16:75389740 A/G cg03315344 chr16:75512273 CHST6 0.41 5.88 0.34 1.21e-8 Dupuytren's disease; CESC cis rs6967414 0.786 rs7804259 chr7:6755448 C/G cg09896999 chr7:6746977 ZNF12 -0.54 -6.37 -0.36 8.11e-10 Hematocrit;Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08117032 chr8:38325144 FGFR1 0.52 6.07 0.35 4.48e-9 Gut microbiome composition (summer); CESC cis rs3736485 0.932 rs4774592 chr15:51778879 C/T cg08986416 chr15:51914746 DMXL2 -0.42 -5.48 -0.32 9.91e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6991838 0.584 rs61083799 chr8:66487103 C/T cg13398993 chr8:66546079 ARMC1 -0.46 -5.54 -0.32 7.22e-8 Intelligence (multi-trait analysis); CESC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg19163074 chr7:65112434 INTS4L2 0.41 5.18 0.3 4.32e-7 Aortic root size; CESC cis rs9908102 0.740 rs73981611 chr17:12904084 C/T cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg23161317 chr6:28129485 ZNF389 0.47 5.89 0.34 1.18e-8 Depression; CESC cis rs2408955 0.521 rs7301003 chr12:48550227 A/G cg24011408 chr12:48396354 COL2A1 0.5 7.48 0.42 1.12e-12 Glycated hemoglobin levels; CESC cis rs2306032 0.575 rs7111517 chr11:46803708 A/C cg25783544 chr11:47291846 MADD -0.43 -5.09 -0.3 6.64e-7 Total body bone mineral density; CESC cis rs654950 0.934 rs654220 chr1:42002556 A/T cg06885757 chr1:42089581 HIVEP3 -0.65 -10.46 -0.54 1.14e-21 Airway imaging phenotypes; CESC cis rs7937682 0.575 rs34888817 chr11:111756455 C/T cg22437258 chr11:111473054 SIK2 -0.48 -5.31 -0.31 2.31e-7 Primary sclerosing cholangitis; CESC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg06456125 chr7:65229604 NA -0.38 -5.04 -0.3 8.73e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21275663 chr21:45744644 PFKL -0.51 -6.12 -0.35 3.33e-9 Gut microbiome composition (summer); CESC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg17971929 chr21:40555470 PSMG1 -0.58 -7.57 -0.42 6.01e-13 Menarche (age at onset); CESC cis rs9905704 0.813 rs304269 chr17:56802059 A/G cg12560992 chr17:57184187 TRIM37 -0.6 -7.56 -0.42 6.51e-13 Testicular germ cell tumor; CESC cis rs7208859 0.725 rs7342938 chr17:29189830 A/G cg19761014 chr17:28927070 LRRC37B2 0.57 5.71 0.33 2.96e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10896135 0.526 rs12795774 chr11:66381517 T/C cg24851651 chr11:66362959 CCS -0.54 -7.2 -0.4 6.06e-12 Bipolar disorder; CESC cis rs8180040 0.805 rs17410853 chr3:47363971 G/T cg27129171 chr3:47204927 SETD2 -0.66 -9.99 -0.52 3.66e-20 Colorectal cancer; CESC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg10691866 chr7:65817282 TPST1 -0.34 -5.46 -0.32 1.08e-7 Aortic root size; CESC cis rs10504229 0.679 rs16921676 chr8:58052386 G/T cg22535103 chr8:58192502 C8orf71 -0.69 -7.45 -0.42 1.33e-12 Developmental language disorder (linguistic errors); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00577969 chr11:122156457 NA -0.4 -6.51 -0.37 3.7e-10 Gambling; CESC cis rs9811920 0.809 rs4577503 chr3:99657922 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.42 -5.41 -0.32 1.44e-7 Axial length; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11094161 chr14:57736037 MUDENG;EXOC5 -0.43 -6.31 -0.36 1.15e-9 Gut microbiota (bacterial taxa); CESC cis rs3820928 1.000 rs4675119 chr2:227774635 A/C cg05526886 chr2:227700861 RHBDD1 -0.39 -5.15 -0.3 5.02e-7 Pulmonary function; CESC cis rs7727544 0.735 rs270605 chr5:131651811 C/T cg24060327 chr5:131705240 SLC22A5 -0.65 -8.74 -0.47 2.8e-16 Blood metabolite levels; CESC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg14393609 chr7:65229607 NA -0.41 -5.77 -0.33 2.21e-8 Aortic root size; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg04306489 chr17:16593582 CCDC144A -0.47 -6.37 -0.36 8.48e-10 Thyroid stimulating hormone; CESC cis rs13091206 1 rs13091206 chr3:49238718 A/G cg07636037 chr3:49044803 WDR6 0.84 10.06 0.53 2.18e-20 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1448094 0.781 rs7959093 chr12:86335502 C/A cg02569458 chr12:86230093 RASSF9 0.44 6.29 0.36 1.3e-9 Major depressive disorder; CESC cis rs3793683 0.545 rs12784407 chr10:134589631 A/G cg26818010 chr10:134567672 INPP5A -0.91 -11.05 -0.56 1.3e-23 Migraine; CESC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.77 11.06 0.56 1.26e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs9815354 1.000 rs1612124 chr3:41967893 C/A cg03022575 chr3:42003672 ULK4 -0.46 -5.37 -0.31 1.76e-7 Pulse pressure;Diastolic blood pressure; CESC trans rs208520 0.690 rs1351867 chr6:66760995 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 12.07 0.6 5.01e-27 Exhaled nitric oxide output; CESC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg22963979 chr7:1858916 MAD1L1 -0.38 -5.14 -0.3 5.29e-7 Bipolar disorder and schizophrenia; CESC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg11764359 chr7:65958608 NA -0.78 -11.38 -0.57 1.07e-24 Aortic root size; CESC cis rs35955747 0.870 rs7289189 chr22:31657182 C/T cg25791279 chr22:32026902 PISD -0.49 -5.79 -0.34 1.99e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs9325144 0.600 rs12227663 chr12:38734922 C/T cg26384229 chr12:38710491 ALG10B -0.56 -7.82 -0.43 1.27e-13 Morning vs. evening chronotype; CESC cis rs2249694 0.960 rs2515642 chr10:135352013 C/T cg20169779 chr10:135381914 SYCE1 0.4 5.28 0.31 2.76e-7 Obesity-related traits; CESC cis rs7084402 0.565 rs7912792 chr10:60335179 C/T cg07615347 chr10:60278583 BICC1 0.4 5.83 0.34 1.57e-8 Refractive error; CESC trans rs2727020 0.521 rs10839285 chr11:49496852 T/G cg03929089 chr4:120376271 NA 0.72 8.84 0.48 1.35e-16 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08328324 chr8:33370759 C8orf41 0.49 6.78 0.38 8.01e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg19770292 chr5:1868693 NA 0.3 5.09 0.3 6.71e-7 Cardiovascular disease risk factors; CESC cis rs1215050 0.791 rs10856931 chr4:98819306 C/T cg05340658 chr4:99064831 C4orf37 0.51 6.62 0.38 1.98e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs6500602 0.627 rs709632 chr16:4587811 C/G cg08645402 chr16:4508243 NA -0.4 -6.12 -0.35 3.36e-9 Schizophrenia; CESC cis rs2806561 0.514 rs10917360 chr1:23539010 C/T cg19743168 chr1:23544995 NA 0.37 5.6 0.33 5.37e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05341670 chr1:54518153 TMEM59;C1orf83 -0.56 -6.31 -0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs9354352 0.935 rs9354354 chr6:66699333 A/G cg07460842 chr6:66804631 NA -0.66 -9.83 -0.52 1.18e-19 Initial pursuit acceleration in psychotic disorders; CESC cis rs2882667 0.858 rs11956159 chr5:138408568 T/C cg04439458 chr5:138467593 SIL1 -0.36 -5.74 -0.33 2.59e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1801251 1.000 rs6738386 chr2:233602028 T/C cg08000102 chr2:233561755 GIGYF2 0.64 9.1 0.49 2.29e-17 Coronary artery disease; CESC cis rs12701220 0.553 rs34062359 chr7:1139076 C/T cg23978390 chr7:1156363 C7orf50 0.59 5.29 0.31 2.6e-7 Bronchopulmonary dysplasia; CESC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.03 -0.35 5.59e-9 Total body bone mineral density; CESC cis rs1983891 0.673 rs9381083 chr6:41570250 T/A cg20194872 chr6:41519635 FOXP4 0.44 6.32 0.36 1.09e-9 Prostate cancer; CESC cis rs2433610 1 rs2433610 chr15:45686091 C/T cg21523688 chr15:45319037 SORD -0.77 -5.17 -0.3 4.7e-7 Serum metabolite levels; CESC cis rs722599 0.628 rs12896360 chr14:75278181 A/C cg11812906 chr14:75593930 NEK9 0.42 5.16 0.3 4.83e-7 IgG glycosylation; CESC cis rs8072100 0.713 rs2292346 chr17:45455473 G/A cg08085267 chr17:45401833 C17orf57 -0.51 -6.49 -0.37 4.12e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01089395 chr6:139094051 CCDC28A 0.46 6.29 0.36 1.3e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4466137 0.953 rs6869030 chr5:83007311 C/T cg16102102 chr5:83017553 HAPLN1 -0.49 -7.05 -0.4 1.56e-11 Prostate cancer; CESC cis rs6968419 0.755 rs2402057 chr7:115897096 C/T cg02561103 chr7:115862891 TES 0.41 5.28 0.31 2.7e-7 Intraocular pressure; CESC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg10253484 chr15:75165896 SCAMP2 -0.53 -7.11 -0.4 1.09e-11 Breast cancer; CESC cis rs12711979 0.509 rs13005405 chr2:3826324 C/T cg17052675 chr2:3827356 NA -0.67 -11.05 -0.56 1.35e-23 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs2050392 0.792 rs9338188 chr10:30721963 G/C cg18806716 chr10:30721971 MAP3K8 -0.41 -5.8 -0.34 1.85e-8 Inflammatory bowel disease; CESC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg22823121 chr1:150693482 HORMAD1 0.47 6.6 0.38 2.22e-10 Melanoma; CESC cis rs8180040 0.966 rs1872164 chr3:47415100 G/A cg27129171 chr3:47204927 SETD2 -0.64 -10.03 -0.52 2.77e-20 Colorectal cancer; CESC cis rs4237845 0.537 rs10877031 chr12:58266695 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.5 5.62 0.33 4.83e-8 Intelligence (multi-trait analysis); CESC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg21951975 chr1:209979733 IRF6 0.46 8.16 0.45 1.32e-14 Monobrow; CESC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.08 20.46 0.78 1.77e-56 Prudent dietary pattern; CESC cis rs748404 0.697 rs473554 chr15:43568207 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.83 0.43 1.19e-13 Lung cancer; CESC cis rs477692 0.967 rs496692 chr10:131429100 C/T cg05714579 chr10:131428358 MGMT 0.51 6.88 0.39 4.41e-11 Response to temozolomide; CESC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg26343298 chr8:95960752 TP53INP1 0.37 6.1 0.35 3.7e-9 Type 2 diabetes; CESC cis rs17102884 0.506 rs887746 chr14:75403817 C/T cg08847533 chr14:75593920 NEK9 -0.42 -5.29 -0.31 2.59e-7 Neuroticism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17902007 chr13:101184847 A2LD1 0.49 6.61 0.38 2.05e-10 Fibrinogen levels; CESC cis rs2243480 1.000 rs13247184 chr7:65358928 A/G cg18252515 chr7:66147081 NA -1.18 -11.4 -0.57 9.2e-25 Diabetic kidney disease; CESC cis rs875971 0.564 rs313804 chr7:65514622 A/G cg11764359 chr7:65958608 NA 0.88 13.01 0.62 3.05e-30 Aortic root size; CESC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg14403583 chr14:105418241 AHNAK2 -0.57 -7.86 -0.43 9.9e-14 Rheumatoid arthritis; CESC cis rs6582630 0.513 rs1596446 chr12:38282160 C/T cg26384229 chr12:38710491 ALG10B -0.66 -9.14 -0.49 1.69e-17 Drug-induced liver injury (flucloxacillin); CESC cis rs2880765 0.743 rs4551990 chr15:86015287 A/C cg10818794 chr15:86012489 AKAP13 -0.36 -5.61 -0.33 5.16e-8 Coronary artery disease; CESC cis rs2304069 0.954 rs9324638 chr5:149400718 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.82 -9.76 -0.51 2.06e-19 HIV-1 control; CESC cis rs796364 0.951 rs6722092 chr2:201059371 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.1 0.35 3.68e-9 Schizophrenia; CESC trans rs35110281 0.744 rs162396 chr21:44947807 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.57 0.37 2.65e-10 Mean corpuscular volume; CESC cis rs863345 0.967 rs2317957 chr1:158467487 A/C cg12129480 chr1:158549410 OR10X1 -0.32 -6.27 -0.36 1.42e-9 Pneumococcal bacteremia; CESC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg13206674 chr6:150067644 NUP43 0.46 6.63 0.38 1.84e-10 Lung cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23959119 chr19:42806179 PRR19;PAFAH1B3 -0.48 -6.25 -0.36 1.67e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15042806 chr16:23652268 DCTN5;PALB2 -0.45 -6.5 -0.37 4.04e-10 Gambling; CESC cis rs3741151 1.000 rs7122825 chr11:73061324 C/T cg17517138 chr11:73019481 ARHGEF17 1.02 6.92 0.39 3.3e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs1153858 1.000 rs3759899 chr15:45655903 T/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.96 0.34 7.92e-9 Homoarginine levels; CESC cis rs72945132 0.882 rs12278741 chr11:70135742 A/G cg14191688 chr11:70257035 CTTN 0.41 5.27 0.31 2.9e-7 Coronary artery disease; CESC cis rs1375194 0.606 rs935625 chr2:33811516 C/G cg04131969 chr2:33951647 MYADML -0.52 -6.43 -0.37 6.09e-10 Response to antidepressants in depression; CESC cis rs748404 0.660 rs493377 chr15:43773467 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.9 0.44 7.27e-14 Lung cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13088374 chr7:43965618 URGCP;UBE2D4 -0.5 -6.0 -0.35 6.42e-9 Ulcerative colitis; CESC cis rs66887589 0.934 rs6817317 chr4:120542827 A/G cg09307838 chr4:120376055 NA -0.46 -6.27 -0.36 1.46e-9 Diastolic blood pressure; CESC cis rs7845219 0.544 rs7001535 chr8:95921090 C/G cg13393036 chr8:95962371 TP53INP1 -0.42 -7.77 -0.43 1.69e-13 Type 2 diabetes; CESC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.5 0.32 9.14e-8 Bipolar disorder; CESC trans rs4349753 0.663 rs10065677 chr5:144070311 C/T cg22407458 chr6:35109121 TCP11 0.5 6.28 0.36 1.37e-9 Photic sneeze reflex; CESC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg17376030 chr22:41985996 PMM1 0.75 7.88 0.44 8.52e-14 Crohn's disease;Inflammatory bowel disease; CESC cis rs12142240 0.692 rs7529674 chr1:46818508 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs963731 0.649 rs297150 chr2:39326164 C/T cg04010122 chr2:39346883 SOS1 -0.67 -5.4 -0.31 1.47e-7 Corticobasal degeneration; CESC cis rs34779708 0.931 rs4934719 chr10:35376769 T/C cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs875971 0.638 rs6460305 chr7:66060408 G/A cg26939375 chr7:64535504 NA -0.64 -8.62 -0.47 6.24e-16 Aortic root size; CESC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg03351412 chr1:154909251 PMVK 0.58 7.66 0.43 3.41e-13 Prostate cancer; CESC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.33 0.36 1.04e-9 Bipolar disorder; CESC cis rs7267979 1.000 rs2482940 chr20:25349830 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -15.92 -0.7 1.72e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs11676348 0.818 rs4674256 chr2:218987893 A/T cg00012203 chr2:219082015 ARPC2 -0.56 -7.31 -0.41 3.19e-12 Ulcerative colitis; CESC cis rs6831352 0.505 rs11722561 chr4:100088737 T/A cg12011299 chr4:100065546 ADH4 0.41 5.76 0.33 2.39e-8 Alcohol dependence; CESC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg13770153 chr20:60521292 NA -0.44 -5.7 -0.33 3.2e-8 Body mass index; CESC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg04546413 chr19:29218101 NA 0.45 6.77 0.38 8.24e-11 Methadone dose in opioid dependence; CESC trans rs459571 0.959 rs392134 chr9:136909008 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.66 -8.6 -0.47 7.24e-16 Platelet distribution width; CESC cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg23283495 chr1:209979779 IRF6 0.48 5.59 0.32 5.57e-8 Cleft lip with or without cleft palate; CESC cis rs6942756 0.876 rs28636722 chr7:129015151 C/T cg02491457 chr7:128862824 NA -0.58 -8.07 -0.44 2.49e-14 White matter hyperintensity burden; CESC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg24829409 chr8:58192753 C8orf71 -0.65 -7.36 -0.41 2.29e-12 Developmental language disorder (linguistic errors); CESC cis rs473651 0.935 rs477041 chr2:239355995 C/G cg18131467 chr2:239335373 ASB1 -1.03 -20.53 -0.78 1.08e-56 Multiple system atrophy; CESC cis rs916888 0.821 rs199505 chr17:44859410 A/G cg14517863 chr17:44321492 NA -0.4 -5.16 -0.3 4.79e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3747547 1.000 rs11790880 chr9:37918219 A/T cg13774184 chr9:37916125 SHB -0.73 -6.14 -0.35 2.96e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg17971929 chr21:40555470 PSMG1 -0.58 -7.54 -0.42 7.55e-13 Menarche (age at onset); CESC cis rs7429990 0.901 rs7431567 chr3:48027832 G/T cg11946769 chr3:48343235 NME6 -0.5 -6.07 -0.35 4.4e-9 Educational attainment (years of education); CESC cis rs7084402 0.523 rs10740730 chr10:60334939 T/C cg07615347 chr10:60278583 BICC1 0.4 5.84 0.34 1.53e-8 Refractive error; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02239891 chr2:214016774 IKZF2 -0.45 -6.04 -0.35 5.09e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8062405 1.000 rs4788102 chr16:28873398 G/A cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs28489187 0.706 rs12124170 chr1:85811182 A/G cg16011679 chr1:85725395 C1orf52 0.55 6.37 0.36 8.25e-10 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs7224314 1.000 rs8075952 chr17:65381358 C/T cg01507342 chr17:65387096 PITPNC1 -0.48 -5.68 -0.33 3.45e-8 Diisocyanate-induced asthma; CESC cis rs61931739 0.500 rs7303318 chr12:34467789 T/C cg23762105 chr12:34175262 ALG10 -0.4 -5.11 -0.3 6.06e-7 Morning vs. evening chronotype; CESC cis rs10927875 0.632 rs1122068 chr1:16127480 G/C cg05821634 chr1:16164109 FLJ37453 0.35 5.04 0.3 8.77e-7 Dilated cardiomyopathy; CESC cis rs6456156 0.565 rs7750209 chr6:167482895 T/G cg07741184 chr6:167504864 NA 0.37 6.36 0.36 8.83e-10 Primary biliary cholangitis; CESC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg05872129 chr22:39784769 NA -0.83 -11.38 -0.57 1.05e-24 Intelligence (multi-trait analysis); CESC cis rs11676348 0.846 rs4674259 chr2:218991005 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.48 -6.25 -0.36 1.61e-9 Ulcerative colitis; CESC cis rs10751667 0.621 rs7394862 chr11:927500 T/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.26 -0.31 2.96e-7 Alzheimer's disease (late onset); CESC cis rs35082559 1 rs35082559 chr2:23896606 CA/C cg08917208 chr2:24149416 ATAD2B 0.73 8.0 0.44 3.79e-14 Granulocyte percentage of myeloid white cells; CESC cis rs2236918 0.643 rs3121389 chr1:242020264 C/T cg17736920 chr1:242011382 EXO1 0.5 6.23 0.36 1.8e-9 Menopause (age at onset); CESC cis rs1178968 1.000 rs757939 chr7:72778108 T/C cg25889504 chr7:72793014 NA 0.51 5.42 0.32 1.36e-7 Triglyceride levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25425078 chr12:4381777 CCND2 -0.6 -7.64 -0.42 4.02e-13 Gut microbiome composition (summer); CESC cis rs6938 0.618 rs62029167 chr15:75228350 G/A cg09165964 chr15:75287851 SCAMP5 0.46 6.24 0.36 1.74e-9 Breast cancer; CESC cis rs11122272 0.735 rs2790890 chr1:231514567 C/T cg06096015 chr1:231504339 EGLN1 0.42 6.11 0.35 3.53e-9 Hemoglobin concentration; CESC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.08 -13.24 -0.63 4.53e-31 Gut microbiome composition (summer); CESC cis rs453301 0.653 rs7005133 chr8:8901222 T/G cg06636001 chr8:8085503 FLJ10661 0.51 6.4 0.37 6.84e-10 Joint mobility (Beighton score); CESC cis rs7927771 0.839 rs59360790 chr11:47669175 T/C cg18512352 chr11:47633146 NA -0.46 -7.27 -0.41 4.04e-12 Subjective well-being; CESC cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg06484146 chr7:12443880 VWDE -0.78 -8.78 -0.47 2.01e-16 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07503211 chr7:5402297 TNRC18 -0.56 -6.92 -0.39 3.4e-11 Gut microbiome composition (summer); CESC cis rs965513 1.000 rs965513 chr9:100556109 A/G cg13688889 chr9:100608707 NA -0.58 -8.26 -0.45 6.88e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs13253111 0.624 rs7832318 chr8:28110414 A/G cg26534493 chr8:28060551 NA 0.45 6.84 0.39 5.47e-11 Childhood body mass index; CESC cis rs72627123 0.867 rs73301500 chr14:74473413 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.8 5.79 0.34 1.99e-8 Morning vs. evening chronotype; CESC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg17372223 chr3:52568218 NT5DC2 0.38 5.19 0.3 4.14e-7 Bipolar disorder; CESC cis rs919433 0.963 rs2043016 chr2:198146381 C/T cg10820045 chr2:198174542 NA -0.44 -6.87 -0.39 4.66e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2637266 0.807 rs2579762 chr10:78318879 A/C cg18941641 chr10:78392320 NA 0.33 5.85 0.34 1.41e-8 Pulmonary function; CESC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg00800038 chr16:89945340 TCF25 -0.92 -7.62 -0.42 4.38e-13 Skin colour saturation; CESC cis rs7617773 0.817 rs6796490 chr3:48237104 A/C cg11946769 chr3:48343235 NME6 0.63 8.7 0.47 3.5e-16 Coronary artery disease; CESC cis rs4865169 0.934 rs3796531 chr4:57850846 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.49 -6.91 -0.39 3.56e-11 Breast cancer; CESC cis rs854765 0.547 rs2955359 chr17:17946730 T/C cg04398451 chr17:18023971 MYO15A 0.73 10.55 0.54 5.95e-22 Total body bone mineral density; CESC cis rs1707322 0.682 rs28490344 chr1:46197948 C/T cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3126085 0.877 rs12133847 chr1:152170101 T/G cg03465714 chr1:152285911 FLG -0.45 -5.5 -0.32 8.8e-8 Atopic dermatitis; CESC cis rs7130144 0.541 rs73572221 chr11:130459948 A/G cg26307797 chr11:130446613 NA -0.74 -6.36 -0.36 8.72e-10 Urate levels in lean individuals; CESC cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg25204440 chr1:209979598 IRF6 0.59 5.92 0.34 9.82e-9 Cleft lip with or without cleft palate; CESC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg06873352 chr17:61820015 STRADA 0.71 12.39 0.61 4.07e-28 Prudent dietary pattern; CESC cis rs1568889 1.000 rs7112860 chr11:28151609 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.81 0.55 8.22e-23 Bipolar disorder; CESC cis rs17253792 0.822 rs10136155 chr14:56049129 G/A cg01858014 chr14:56050164 KTN1 -0.89 -7.05 -0.4 1.58e-11 Putamen volume; CESC cis rs708547 0.599 rs2948348 chr4:57848772 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.59 8.56 0.47 9.53e-16 Response to bleomycin (chromatid breaks); CESC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg24675658 chr1:53192096 ZYG11B 0.53 6.78 0.38 7.96e-11 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17461271 chr1:172717683 NA -0.72 -8.39 -0.46 2.87e-15 Gut microbiome composition (summer); CESC cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg10556349 chr10:835070 NA 0.54 5.32 0.31 2.2e-7 Eosinophil percentage of granulocytes; CESC cis rs8114671 0.562 rs6120757 chr20:33488771 C/T cg24642439 chr20:33292090 TP53INP2 0.44 5.32 0.31 2.22e-7 Height; CESC cis rs78456975 1.000 rs13422995 chr2:1553554 C/A cg26248373 chr2:1572462 NA -0.57 -5.31 -0.31 2.29e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs1707322 0.691 rs61784803 chr1:46179271 C/A cg05343316 chr1:45956843 TESK2 -0.51 -6.2 -0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg04055107 chr11:65626734 MUS81;CFL1 -0.46 -5.28 -0.31 2.65e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21605566 chr1:14075549 PRDM2 -0.6 -6.91 -0.39 3.59e-11 Gut microbiome composition (summer); CESC cis rs2425143 1.000 rs6058303 chr20:34290281 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -7.08 -0.4 1.31e-11 Blood protein levels; CESC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg00409905 chr10:38381863 ZNF37A -0.52 -7.13 -0.4 9.33e-12 Extrinsic epigenetic age acceleration; CESC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.77 0.38 8.38e-11 Bipolar disorder; CESC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg03709012 chr19:19516395 GATAD2A -0.96 -14.11 -0.66 4.09e-34 Tonsillectomy; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg25748391 chr11:1330779 TOLLIP;LOC255512 0.46 6.49 0.37 4.24e-10 Thyroid stimulating hormone; CESC cis rs12142240 0.698 rs966907 chr1:46817125 C/G cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg26314531 chr2:26401878 FAM59B -0.62 -6.9 -0.39 3.92e-11 Gut microbiome composition (summer); CESC cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg11366901 chr6:160182831 ACAT2 0.69 8.21 0.45 9.67e-15 Age-related macular degeneration (geographic atrophy); CESC cis rs6736093 1.000 rs79688911 chr2:112657907 C/T cg12686935 chr2:112915763 FBLN7 -0.42 -5.17 -0.3 4.56e-7 Coronary artery disease; CESC cis rs8060686 0.641 rs76984161 chr16:68139423 C/A cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 4.92e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs7592578 0.679 rs62181020 chr2:191325601 A/C cg10560079 chr2:191398806 TMEM194B -0.59 -5.69 -0.33 3.43e-8 Diastolic blood pressure; CESC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.19 0.49 1.18e-17 Platelet count; CESC cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.51 0.46 1.33e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15005908 chr6:114292723 HDAC2 0.55 6.32 0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs12893668 0.543 rs12147645 chr14:104100208 T/A cg08213375 chr14:104286397 PPP1R13B 0.33 5.36 0.31 1.83e-7 Reticulocyte count; CESC cis rs637571 0.522 rs491973 chr11:65727301 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.65 0.38 1.71e-10 Eosinophil percentage of white cells; CESC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg02428538 chr16:24856791 SLC5A11 0.47 5.03 0.3 9.12e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03533382 chr5:126853128 PRRC1 -0.48 -6.91 -0.39 3.54e-11 Gambling; CESC cis rs7084402 0.935 rs7474570 chr10:60343085 C/G cg07615347 chr10:60278583 BICC1 0.56 8.67 0.47 4.26e-16 Refractive error; CESC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg00933542 chr6:150070202 PCMT1 0.3 5.26 0.31 2.96e-7 Lung cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03592283 chr3:44666723 ZNF197 -0.42 -6.61 -0.38 2.12e-10 Gambling; CESC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg25517755 chr10:38738941 LOC399744 -0.49 -6.35 -0.36 9.08e-10 Extrinsic epigenetic age acceleration; CESC cis rs2882667 0.756 rs11957953 chr5:138479377 G/T cg04439458 chr5:138467593 SIL1 -0.38 -5.84 -0.34 1.52e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs62432291 0.614 rs452112 chr6:159658028 A/G cg14500486 chr6:159655392 FNDC1 -0.61 -6.2 -0.36 2.19e-9 Joint mobility (Beighton score); CESC cis rs4588572 0.643 rs3922654 chr5:77684726 G/A cg11547950 chr5:77652471 NA 0.45 5.71 0.33 3.06e-8 Triglycerides; CESC cis rs7772486 0.875 rs1331640 chr6:146427250 G/A cg05347473 chr6:146136440 FBXO30 0.51 6.57 0.37 2.68e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs897080 0.552 rs1067388 chr2:44642482 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.89 0.34 1.14e-8 Height; CESC cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg01579765 chr21:45077557 HSF2BP -0.53 -9.24 -0.49 8.22e-18 Mean corpuscular volume; CESC cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg17143192 chr8:8559678 CLDN23 0.77 8.87 0.48 1.09e-16 Obesity-related traits; CESC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg13770153 chr20:60521292 NA 0.81 11.91 0.59 1.75e-26 Obesity-related traits; CESC cis rs7605827 0.930 rs7595512 chr2:15678368 C/T cg19274914 chr2:15703543 NA 0.36 6.33 0.36 1.04e-9 Educational attainment (years of education); CESC cis rs9303542 0.625 rs7207109 chr17:46607817 C/T cg04904318 chr17:46607828 HOXB1 -0.68 -7.42 -0.41 1.62e-12 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg22875332 chr1:76189707 ACADM 0.63 6.32 0.36 1.11e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9611565 0.592 rs8779 chr22:42070276 T/C cg06481639 chr22:41940642 POLR3H 0.57 5.74 0.33 2.58e-8 Vitiligo; CESC cis rs11252926 0.510 rs4881371 chr10:554514 G/A cg03684893 chr10:554711 DIP2C -0.47 -7.29 -0.41 3.64e-12 Psychosis in Alzheimer's disease; CESC cis rs9287719 0.578 rs10175555 chr2:10703233 T/C cg00105475 chr2:10696890 NA 0.41 5.64 0.33 4.3e-8 Prostate cancer; CESC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg24578937 chr1:2090814 PRKCZ -0.35 -6.06 -0.35 4.65e-9 Height; CESC cis rs6674176 0.628 rs3791119 chr1:44431362 C/G cg13606994 chr1:44402422 ARTN -0.39 -5.8 -0.34 1.87e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7772486 0.686 rs1292334 chr6:145968288 A/G cg23711669 chr6:146136114 FBXO30 0.98 14.83 0.67 1.26e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.954 rs10518331 chr4:120323595 C/T cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg24399712 chr22:39784796 NA -0.81 -10.81 -0.55 8.15e-23 Intelligence (multi-trait analysis); CESC cis rs2070433 0.752 rs2839220 chr21:47774330 G/C cg12379764 chr21:47803548 PCNT 0.65 6.99 0.39 2.24e-11 Lymphocyte counts; CESC cis rs7216064 1.000 rs8074078 chr17:65838743 A/C cg07042672 chr17:66097459 LOC651250 -0.57 -6.69 -0.38 1.32e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg05863683 chr7:1912471 MAD1L1 0.42 6.21 0.36 2.02e-9 Bipolar disorder and schizophrenia; CESC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.28 -0.31 2.72e-7 Developmental language disorder (linguistic errors); CESC trans rs60843830 1.000 rs55946380 chr2:268293 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.69 8.58 0.47 8.3e-16 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs116095464 0.558 rs28636067 chr5:199415 G/A cg22857025 chr5:266934 NA -1.26 -13.82 -0.65 4.44e-33 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20157693 chr1:1419379 ATAD3B -0.5 -6.4 -0.37 7e-10 Gut microbiome composition (summer); CESC cis rs2777491 0.574 rs2730056 chr15:41735785 A/G cg18705301 chr15:41695430 NDUFAF1 -1.07 -17.08 -0.72 1.34e-44 Ulcerative colitis; CESC cis rs6460942 0.630 rs62451487 chr7:12390464 G/A cg02935154 chr7:12443704 VWDE -0.51 -5.27 -0.31 2.78e-7 Coronary artery disease; CESC cis rs963731 0.579 rs12712630 chr2:39284582 A/G cg04010122 chr2:39346883 SOS1 -0.7 -5.54 -0.32 7.4e-8 Corticobasal degeneration; CESC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg22823121 chr1:150693482 HORMAD1 0.47 7.0 0.39 2.13e-11 Tonsillectomy; CESC cis rs7927771 0.725 rs11570094 chr11:47359706 A/C cg05585544 chr11:47624801 NA 0.41 5.81 0.34 1.77e-8 Subjective well-being; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg07185584 chr20:19997881 NAA20 -0.55 -6.07 -0.35 4.38e-9 Lung cancer in ever smokers; CESC cis rs854765 0.583 rs11078404 chr17:17820487 A/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.34 0.41 2.67e-12 Total body bone mineral density; CESC trans rs9858542 0.953 rs9818590 chr3:49525096 A/G cg21659725 chr3:3221576 CRBN -0.54 -6.37 -0.36 8.2e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs959260 1.000 rs4788892 chr17:73391277 A/G cg12999837 chr17:73267436 MIF4GD -0.48 -5.54 -0.32 7.21e-8 Systemic lupus erythematosus; CESC cis rs11650494 0.908 rs73340392 chr17:47358308 G/A cg08112188 chr17:47440006 ZNF652 1.07 7.53 0.42 7.96e-13 Prostate cancer; CESC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg09359103 chr1:154839909 KCNN3 -0.49 -7.75 -0.43 1.92e-13 Prostate cancer; CESC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg03467027 chr4:99064603 C4orf37 0.48 6.05 0.35 4.87e-9 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg20151795 chr6:28129481 ZNF389 0.4 5.39 0.31 1.58e-7 Depression; CESC cis rs4835473 0.932 rs1580002 chr4:144687660 G/A cg25736465 chr4:144833511 NA -0.43 -6.5 -0.37 4.07e-10 Immature fraction of reticulocytes; CESC cis rs412050 1.000 rs75599828 chr22:22333062 G/C cg17089214 chr22:22089827 YPEL1 0.68 5.57 0.32 6.35e-8 Attention deficit hyperactivity disorder; CESC cis rs1957429 0.520 rs17102258 chr14:65332369 G/A cg23373153 chr14:65346875 NA -0.76 -5.85 -0.34 1.42e-8 Pediatric areal bone mineral density (radius); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08448040 chr3:13521693 HDAC11 0.53 6.93 0.39 3.27e-11 Gut microbiota (bacterial taxa); CESC cis rs599083 0.530 rs2508834 chr11:68175354 C/T cg01657329 chr11:68192670 LRP5 0.45 5.42 0.32 1.37e-7 Bone mineral density (spine); CESC cis rs2370759 0.945 rs10508773 chr10:32575444 C/T cg18270830 chr10:32634957 EPC1 0.73 7.22 0.41 5.35e-12 Sexual dysfunction (female); CESC cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg13628971 chr7:2884303 GNA12 0.41 5.41 0.32 1.39e-7 Height; CESC cis rs9926296 0.546 rs9935541 chr16:89905925 G/C cg04287289 chr16:89883240 FANCA 0.66 8.55 0.46 1.02e-15 Vitiligo; CESC cis rs1729951 0.575 rs361241 chr3:136699561 C/A cg25687071 chr3:136751404 NA 0.38 5.03 0.3 9.06e-7 Neuroticism; CESC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.04 0.4 1.62e-11 Bipolar disorder; CESC cis rs7523050 0.730 rs12734623 chr1:109442654 A/G cg08274380 chr1:109419600 GPSM2 0.91 6.41 0.37 6.51e-10 Fat distribution (HIV); CESC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.21 -0.53 7.17e-21 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15559398 chr3:179322454 NDUFB5;MRPL47 0.65 7.03 0.4 1.79e-11 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg25517755 chr10:38738941 LOC399744 0.43 5.42 0.32 1.32e-7 Extrinsic epigenetic age acceleration; CESC cis rs7259376 0.936 rs7255829 chr19:22537311 C/T cg02657401 chr19:22469223 NA -0.27 -5.29 -0.31 2.63e-7 Menopause (age at onset); CESC cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.03e-7 Colorectal cancer; CESC cis rs9322193 0.962 rs35031906 chr6:149998574 T/C cg07701084 chr6:150067640 NUP43 0.4 5.4 0.31 1.51e-7 Lung cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09199072 chr6:116692265 DSE 0.46 6.07 0.35 4.49e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg27347728 chr4:17578864 LAP3 0.46 5.47 0.32 1.03e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9796 0.745 rs2947493 chr15:41375694 G/A cg12426344 chr15:41135900 SPINT1 -0.23 -5.1 -0.3 6.45e-7 Menopause (age at onset); CESC cis rs4718428 0.705 rs62465692 chr7:66295745 T/C cg18252515 chr7:66147081 NA -0.47 -5.23 -0.31 3.38e-7 Corneal structure; CESC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg27170947 chr2:26402098 FAM59B 0.66 7.37 0.41 2.12e-12 Gut microbiome composition (summer); CESC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg18490616 chr2:88469792 THNSL2 0.55 5.25 0.31 3.06e-7 Plasma clusterin levels; CESC cis rs858239 0.600 rs7341483 chr7:23127657 G/T cg23682824 chr7:23144976 KLHL7 -0.56 -7.83 -0.43 1.18e-13 Cerebrospinal fluid biomarker levels; CESC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg25405998 chr7:65216604 CCT6P1 0.45 5.06 0.3 7.71e-7 Aortic root size; CESC cis rs950776 0.745 rs36045869 chr15:78929498 C/T cg06917634 chr15:78832804 PSMA4 0.56 6.61 0.38 2.14e-10 Sudden cardiac arrest; CESC cis rs9815354 1.000 rs1716997 chr3:41924333 A/G cg03022575 chr3:42003672 ULK4 -0.46 -5.37 -0.31 1.75e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs938554 0.513 rs3775946 chr4:9995256 A/G cg02734326 chr4:10020555 SLC2A9 0.43 5.09 0.3 6.8e-7 Blood metabolite levels; CESC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg20151795 chr6:28129481 ZNF389 0.44 5.34 0.31 1.96e-7 Parkinson's disease; CESC trans rs9831754 1.000 rs9831754 chr3:78353591 A/C cg06416733 chr12:103344890 NA 0.36 6.15 0.35 2.79e-9 Calcium levels; CESC cis rs2415984 0.579 rs1389606 chr14:46964226 T/C cg14871534 chr14:47121158 RPL10L 0.35 5.32 0.31 2.24e-7 Number of children ever born; CESC cis rs7937682 0.961 rs1784784 chr11:111483185 C/T cg22437258 chr11:111473054 SIK2 0.7 9.55 0.51 9.3e-19 Primary sclerosing cholangitis; CESC cis rs7208859 0.623 rs9914499 chr17:29107588 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11190604 1.000 rs3763695 chr10:102269206 A/G cg07080220 chr10:102295463 HIF1AN 0.67 6.22 0.36 1.91e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs4242434 0.889 rs11785755 chr8:22453223 C/A cg03733263 chr8:22462867 KIAA1967 0.9 13.45 0.64 8.72e-32 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs4450798 0.793 rs28687597 chr3:13757613 T/C cg05589046 chr3:13742034 LOC285375 0.37 5.23 0.31 3.46e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg04414720 chr1:150670196 GOLPH3L 0.58 7.89 0.44 7.87e-14 Melanoma; CESC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg09359103 chr1:154839909 KCNN3 -0.68 -12.74 -0.62 2.56e-29 Prostate cancer; CESC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg00310523 chr12:86230176 RASSF9 0.36 5.55 0.32 6.85e-8 Major depressive disorder; CESC cis rs17407555 0.606 rs59871456 chr4:10014441 G/A cg00071950 chr4:10020882 SLC2A9 -0.6 -6.13 -0.35 3.09e-9 Schizophrenia (age at onset); CESC cis rs7193541 0.640 rs4072222 chr16:74706736 A/C cg01733217 chr16:74700730 RFWD3 1.03 20.47 0.78 1.73e-56 Multiple myeloma; CESC cis rs2204008 0.774 rs4534658 chr12:38246783 G/A cg13010199 chr12:38710504 ALG10B 0.46 5.79 0.33 2.02e-8 Bladder cancer; CESC cis rs2228479 0.702 rs12599561 chr16:89894358 C/G cg04013166 chr16:89971882 TCF25 0.73 5.77 0.33 2.2e-8 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26759515 chr16:67515027 ATP6V0D1 0.63 7.33 0.41 2.76e-12 Gut microbiome composition (summer); CESC cis rs854765 0.583 rs11656840 chr17:17837354 C/T cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.89e-9 Total body bone mineral density; CESC cis rs7202877 0.611 rs4888395 chr16:75413715 T/G cg04384234 chr16:75411784 CFDP1 -0.49 -5.89 -0.34 1.16e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs539096 0.501 rs713191 chr1:44314553 A/G cg12908607 chr1:44402522 ARTN -0.46 -6.6 -0.38 2.26e-10 Intelligence (multi-trait analysis); CESC cis rs1178968 1.000 rs1178968 chr7:72767451 T/C cg25889504 chr7:72793014 NA 0.5 5.1 0.3 6.62e-7 Triglyceride levels; CESC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg11301795 chr4:187892539 NA -0.74 -12.36 -0.6 5.13e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs8060686 0.545 rs75229939 chr16:68164949 G/A cg26727032 chr16:67993705 SLC12A4 -0.5 -5.47 -0.32 1.03e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs7914558 0.966 rs3902934 chr10:104746649 A/G cg15744005 chr10:104629667 AS3MT -0.33 -5.26 -0.31 3.02e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4253772 0.744 rs1134224 chr22:46633371 A/T cg24881330 chr22:46731750 TRMU 0.74 8.05 0.44 2.75e-14 LDL cholesterol;Cholesterol, total; CESC cis rs1008375 0.898 rs4698623 chr4:17594702 T/C cg04450456 chr4:17643702 FAM184B 0.37 5.23 0.31 3.44e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7772486 0.875 rs9373483 chr6:146364194 A/G cg23711669 chr6:146136114 FBXO30 0.83 12.12 0.6 3.46e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg05132306 chr1:1846340 CALML6 -0.31 -6.57 -0.37 2.6e-10 Body mass index; CESC cis rs2997447 0.802 rs72884792 chr1:26436688 G/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs6502050 0.871 rs6502056 chr17:80070912 C/G cg11859384 chr17:80120422 CCDC57 0.38 5.24 0.31 3.24e-7 Life satisfaction; CESC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg12963246 chr6:28129442 ZNF389 0.41 5.56 0.32 6.7e-8 Parkinson's disease; CESC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg11764359 chr7:65958608 NA 0.81 11.89 0.59 2.11e-26 Aortic root size; CESC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg18876405 chr7:65276391 NA -0.51 -7.1 -0.4 1.15e-11 Aortic root size; CESC cis rs7100689 0.577 rs2185427 chr10:82056667 G/T cg09936400 chr10:82049201 MAT1A -0.4 -6.12 -0.35 3.35e-9 Post bronchodilator FEV1; CESC cis rs2439831 0.867 rs3809481 chr15:43662829 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.88 9.41 0.5 2.56e-18 Lung cancer in ever smokers; CESC cis rs796364 0.806 rs77853713 chr2:201006880 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -6.48 -0.37 4.47e-10 Schizophrenia; CESC trans rs8073060 0.572 rs1634683 chr17:33941560 G/C cg19694781 chr19:47549865 TMEM160 -0.69 -6.76 -0.38 8.53e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11342277 chr1:116915598 ATP1A1 0.58 6.49 0.37 4.12e-10 Gut microbiome composition (summer); CESC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -7.41 -0.41 1.68e-12 Developmental language disorder (linguistic errors); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg16419620 chr12:48214187 HDAC7 -0.41 -6.4 -0.37 6.92e-10 Vertical cup-disc ratio; CESC cis rs1577917 0.771 rs6454486 chr6:86433587 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.36 5.05 0.3 8.36e-7 Response to antipsychotic treatment; CESC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs4808199 0.894 rs9304960 chr19:19465529 G/A cg03709012 chr19:19516395 GATAD2A 1.14 12.44 0.61 2.65e-28 Nonalcoholic fatty liver disease; CESC cis rs1865721 1.000 rs62089508 chr18:73193344 C/T cg26385618 chr18:73139727 C18orf62 -0.51 -7.56 -0.42 6.81e-13 Intelligence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06832064 chr1:150551018 MCL1 0.58 6.25 0.36 1.62e-9 Gut microbiome composition (summer); CESC cis rs8005677 1.000 rs4982709 chr14:23394699 C/T cg25600027 chr14:23388339 RBM23 -0.42 -5.15 -0.3 5.16e-7 Cognitive ability (multi-trait analysis); CESC cis rs4595586 0.545 rs925828 chr12:39364222 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg26597838 chr10:835615 NA 0.86 9.05 0.49 3.21e-17 Eosinophil percentage of granulocytes; CESC trans rs34198350 0.687 rs11683689 chr2:48423881 A/C cg04747634 chr16:71264451 HYDIN 0.61 6.08 0.35 4.18e-9 QT interval in Tripanosoma cruzi seropositivity; CESC cis rs4642101 0.686 rs9822382 chr3:12828828 T/G cg24848339 chr3:12840334 CAND2 0.35 5.3 0.31 2.48e-7 QRS complex (12-leadsum); CESC cis rs739401 0.611 rs572373 chr11:3055361 T/C cg25174290 chr11:3078921 CARS 0.55 7.74 0.43 2.14e-13 Longevity; CESC cis rs11577318 0.853 rs7416513 chr1:26647949 G/C cg00852783 chr1:26633632 UBXN11 0.48 6.61 0.38 2.15e-10 Granulocyte percentage of myeloid white cells; CESC cis rs9888739 0.844 rs41476751 chr16:31335906 T/C cg15817542 chr16:31343056 ITGAM -0.42 -5.82 -0.34 1.71e-8 Systemic lupus erythematosus; CESC cis rs2070488 0.861 rs1858740 chr3:38438372 T/C cg24069376 chr3:38537580 EXOG 0.46 8.17 0.45 1.26e-14 Electrocardiographic conduction measures; CESC cis rs854765 0.583 rs8078583 chr17:17811465 C/T cg16928487 chr17:17741425 SREBF1 -0.58 -9.9 -0.52 7.14e-20 Total body bone mineral density; CESC cis rs4664304 0.772 rs10183731 chr2:160740989 A/G cg03641300 chr2:160917029 PLA2R1 0.41 5.72 0.33 2.89e-8 Crohn's disease;Inflammatory bowel disease; CESC trans rs698833 0.669 rs1584885 chr2:44647038 A/C cg02849725 chr11:114310121 REXO2 -0.45 -6.13 -0.35 3.13e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9908102 0.740 rs58842254 chr17:12906222 A/G cg26162695 chr17:12921313 ELAC2 0.46 5.3 0.31 2.43e-7 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03093995 chr9:114393414 DNAJC25-GNG10;DNAJC25 0.49 6.19 0.36 2.34e-9 Gut microbiota (bacterial taxa); CESC cis rs13191362 0.507 rs1954806 chr6:163051858 G/C cg21926612 chr6:163149169 PACRG;PARK2 -0.57 -6.97 -0.39 2.57e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg15664640 chr17:80829946 TBCD -0.62 -8.98 -0.48 5.17e-17 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04282497 chr4:82350883 RASGEF1B 0.56 7.77 0.43 1.73e-13 Fibrinogen levels; CESC cis rs1879734 0.731 rs6661728 chr1:54162471 G/A cg23596471 chr1:54105337 GLIS1 0.35 5.56 0.32 6.52e-8 Mitral valve prolapse; CESC cis rs7605827 0.930 rs12692264 chr2:15539229 T/A cg19274914 chr2:15703543 NA 0.34 6.12 0.35 3.44e-9 Educational attainment (years of education); CESC cis rs12618769 0.597 rs3754883 chr2:99129451 T/C cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs6088580 0.634 rs4911419 chr20:32995873 G/A cg24642439 chr20:33292090 TP53INP2 -0.53 -6.99 -0.39 2.17e-11 Glomerular filtration rate (creatinine); CESC cis rs2933343 0.621 rs728838 chr3:128589013 A/G cg24203234 chr3:128598194 ACAD9 0.41 5.72 0.33 2.91e-8 IgG glycosylation; CESC cis rs6696846 0.905 rs12117194 chr1:205040943 C/G cg00857998 chr1:205179979 DSTYK -0.48 -6.79 -0.38 7.45e-11 Red blood cell count; CESC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg05025164 chr4:1340916 KIAA1530 0.52 7.3 0.41 3.26e-12 Longevity; CESC cis rs2816062 0.786 rs2745320 chr1:18893592 G/A cg18795169 chr1:18902165 NA -0.94 -19.08 -0.76 1.16e-51 Urate levels in lean individuals; CESC cis rs2929278 0.589 rs7174732 chr15:44038463 C/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.55 -7.28 -0.41 3.82e-12 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20159072 chr3:48936248 SLC25A20 0.46 6.02 0.35 5.79e-9 Gut microbiota (bacterial taxa); CESC cis rs863345 0.604 rs10797018 chr1:158490112 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC trans rs7947523 0.813 rs4999940 chr11:80942337 C/T cg21227347 chr9:117374170 C9orf91 0.46 6.08 0.35 4.26e-9 Emphysema imaging phenotypes; CESC cis rs7264396 0.790 rs6060582 chr20:34313297 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.64 -7.6 -0.42 4.97e-13 Total cholesterol levels; CESC cis rs2046867 0.818 rs62249860 chr3:72866073 T/G cg25664220 chr3:72788482 NA -0.45 -6.62 -0.38 2e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs12956009 0.583 rs11663646 chr18:44862895 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.47 -5.98 -0.34 7.27e-9 Educational attainment (years of education); CESC cis rs910316 1.000 rs1047418 chr14:75605792 A/G cg11812906 chr14:75593930 NEK9 0.89 15.02 0.68 2.58e-37 Height; CESC cis rs11642862 1.000 rs11642603 chr16:30886221 C/G cg02466173 chr16:30829666 NA -0.58 -5.67 -0.33 3.72e-8 Tonsillectomy; CESC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.62 0.8 1.92e-60 Prudent dietary pattern; CESC cis rs4268898 0.662 rs2303297 chr2:24432937 C/T cg08917208 chr2:24149416 ATAD2B 0.55 5.27 0.31 2.89e-7 Asthma; CESC cis rs6701037 0.566 rs1883102 chr1:175136793 T/A cg00321850 chr1:175162397 KIAA0040 0.44 6.32 0.36 1.12e-9 Alcohol dependence; CESC cis rs2635047 0.935 rs2635050 chr18:44664131 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 6.4 0.37 6.95e-10 Educational attainment; CESC cis rs4780401 0.609 rs16958588 chr16:11819330 G/A cg01061890 chr16:11836724 TXNDC11 -0.55 -7.56 -0.42 6.67e-13 Rheumatoid arthritis; CESC cis rs72945132 0.882 rs55758686 chr11:70172204 C/T cg00319359 chr11:70116639 PPFIA1 0.76 7.4 0.41 1.86e-12 Coronary artery disease; CESC cis rs72781680 0.821 rs113014365 chr2:24159903 C/T cg08917208 chr2:24149416 ATAD2B 0.63 6.24 0.36 1.73e-9 Lymphocyte counts; CESC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg13206674 chr6:150067644 NUP43 0.43 6.17 0.35 2.58e-9 Lung cancer; CESC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg20203395 chr5:56204925 C5orf35 -0.39 -5.24 -0.31 3.23e-7 Initial pursuit acceleration; CESC cis rs17253792 0.822 rs10083499 chr14:56066590 T/A cg01858014 chr14:56050164 KTN1 -0.85 -6.79 -0.38 7.45e-11 Putamen volume; CESC cis rs2243480 1.000 rs35391607 chr7:65360829 G/A cg18252515 chr7:66147081 NA -1.01 -9.32 -0.5 4.6e-18 Diabetic kidney disease; CESC cis rs11625487 0.609 rs74063377 chr14:77951431 C/G cg20045696 chr14:77926864 AHSA1 -0.71 -5.63 -0.33 4.67e-8 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs2625529 0.689 rs12898868 chr15:72112918 A/G cg16672083 chr15:72433130 SENP8 0.48 7.26 0.41 4.23e-12 Red blood cell count; CESC cis rs920590 0.758 rs17091534 chr8:19670651 C/T cg01411142 chr8:19674711 INTS10 0.49 5.4 0.31 1.48e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs1642645 0.831 rs11210563 chr1:42494633 G/T cg16685388 chr1:42384056 HIVEP3 0.37 5.61 0.33 5.2e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs1788820 1.000 rs1788820 chr18:21101944 A/G cg14672496 chr18:21087552 C18orf8 0.5 6.9 0.39 3.93e-11 Body mass index; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg25752527 chr2:136499146 UBXN4 0.45 6.14 0.35 2.92e-9 Weight; CESC cis rs7605827 0.897 rs10084390 chr2:15597662 C/A cg19274914 chr2:15703543 NA 0.33 5.95 0.34 8.67e-9 Educational attainment (years of education); CESC cis rs910316 1.000 rs175449 chr14:75590846 A/T cg08847533 chr14:75593920 NEK9 -0.97 -18.7 -0.75 2.51e-50 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05628496 chr17:17991167 DRG2 0.52 6.8 0.39 6.75e-11 Gut microbiota (bacterial taxa); CESC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg21724239 chr8:58056113 NA 0.57 5.87 0.34 1.3e-8 Developmental language disorder (linguistic errors); CESC cis rs4692589 0.965 rs6842442 chr4:170933203 C/T cg19918862 chr4:170955249 NA 0.37 5.83 0.34 1.59e-8 Anxiety disorder; CESC cis rs7666738 0.716 rs7656233 chr4:99079237 G/A cg05340658 chr4:99064831 C4orf37 0.75 10.74 0.55 1.38e-22 Colonoscopy-negative controls vs population controls; CESC cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg18351406 chr4:77819688 ANKRD56 0.54 6.76 0.38 8.77e-11 Emphysema distribution in smoking; CESC cis rs11711311 1.000 rs3806641 chr3:113465761 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.74 10.5 0.54 8.57e-22 IgG glycosylation; CESC cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg27478167 chr7:817139 HEATR2 -0.46 -5.4 -0.31 1.52e-7 Cerebrospinal P-tau181p levels; CESC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg22520471 chr17:61851767 DDX42;CCDC47 -0.81 -11.78 -0.59 4.88e-26 Prudent dietary pattern; CESC cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg00031303 chr3:195681400 NA -0.46 -5.91 -0.34 1.06e-8 Pancreatic cancer; CESC cis rs7647973 0.925 rs9881860 chr3:49352522 A/T cg06212747 chr3:49208901 KLHDC8B 0.57 7.17 0.4 7.69e-12 Menarche (age at onset); CESC cis rs9733 0.744 rs4970976 chr1:150779524 T/A cg22823121 chr1:150693482 HORMAD1 -0.4 -6.1 -0.35 3.81e-9 Tonsillectomy; CESC cis rs1878931 0.501 rs9635563 chr16:3416940 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.77 10.42 0.54 1.58e-21 Body mass index (adult); CESC cis rs9457247 0.967 rs447042 chr6:167405435 C/T cg23791538 chr6:167370224 RNASET2 -0.59 -8.54 -0.46 1.09e-15 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22337509 chr1:204093899 SOX13 -0.48 -6.4 -0.37 6.86e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg23711669 chr6:146136114 FBXO30 0.95 12.44 0.61 2.75e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs4716602 0.828 rs10270046 chr7:156159047 T/C cg04090468 chr7:156181990 NA 0.4 5.15 0.3 5.18e-7 Anti-saccade response; CESC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg11764359 chr7:65958608 NA -0.81 -11.13 -0.56 7.19e-24 Aortic root size; CESC cis rs7208859 0.623 rs78071511 chr17:29128154 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs897984 0.609 rs4889609 chr16:31026427 A/G cg00531865 chr16:30841666 NA -0.4 -5.58 -0.32 5.95e-8 Dementia with Lewy bodies; CESC cis rs113835537 0.529 rs75685325 chr11:66235242 A/G cg22134325 chr11:66188745 NPAS4 0.43 6.48 0.37 4.41e-10 Airway imaging phenotypes; CESC cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg24308560 chr3:49941425 MST1R 0.62 9.01 0.48 4.25e-17 Intelligence (multi-trait analysis); CESC cis rs7904368 0.754 rs12246217 chr10:16853349 G/C cg23933602 chr10:16859644 RSU1 0.72 6.52 0.37 3.52e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs2637266 0.714 rs11594217 chr10:78385088 G/T cg18941641 chr10:78392320 NA -0.35 -5.76 -0.33 2.29e-8 Pulmonary function; CESC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg07677032 chr17:61819896 STRADA 0.45 5.91 0.34 1.03e-8 Prudent dietary pattern; CESC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg11764359 chr7:65958608 NA 0.79 11.32 0.57 1.67e-24 Aortic root size; CESC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg06494592 chr3:125709126 NA -0.48 -5.11 -0.3 6.1e-7 Blood pressure (smoking interaction); CESC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg26939375 chr7:64535504 NA 0.5 6.47 0.37 4.83e-10 Aortic root size; CESC cis rs4727963 0.846 rs10237575 chr7:122706184 A/G cg03640110 chr7:122635026 TAS2R16 -0.37 -5.7 -0.33 3.11e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs12220238 0.915 rs11000945 chr10:76030739 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.04 0.3 8.74e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg17372223 chr3:52568218 NT5DC2 0.44 6.61 0.38 2.12e-10 Bipolar disorder; CESC cis rs7107174 1.000 rs72931639 chr11:78036703 C/T cg02023728 chr11:77925099 USP35 0.51 6.82 0.39 6.24e-11 Testicular germ cell tumor; CESC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg23758822 chr17:41437982 NA 1.03 14.48 0.66 2.1e-35 Menopause (age at onset); CESC trans rs8073060 0.586 rs225292 chr17:33926383 G/A cg19694781 chr19:47549865 TMEM160 -0.63 -6.92 -0.39 3.31e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs2228479 0.850 rs12600051 chr16:89992072 G/T cg06558623 chr16:89946397 TCF25 1.17 9.0 0.48 4.39e-17 Skin colour saturation; CESC cis rs9951602 0.850 rs56367211 chr18:76677563 G/T cg00806245 chr18:76673096 NA 0.52 6.24 0.36 1.71e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01500421 chr5:140070872 HARS2;HARS 0.53 6.24 0.36 1.73e-9 Gut microbiome composition (summer); CESC trans rs8073060 0.586 rs2626625 chr17:34027607 C/G cg19694781 chr19:47549865 TMEM160 -0.72 -6.47 -0.37 4.69e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs910316 0.763 rs175016 chr14:75459633 C/T cg11812906 chr14:75593930 NEK9 -0.82 -13.27 -0.63 3.75e-31 Height; CESC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg24829409 chr8:58192753 C8orf71 -0.59 -7.34 -0.41 2.64e-12 Developmental language disorder (linguistic errors); CESC trans rs10411161 0.702 rs10403189 chr19:52400673 A/G cg22319618 chr22:45562946 NUP50 0.78 7.81 0.43 1.37e-13 Breast cancer; CESC cis rs9457247 1.000 rs422694 chr6:167406074 G/T cg25258033 chr6:167368657 RNASET2 0.39 5.89 0.34 1.15e-8 Crohn's disease; CESC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg18016565 chr1:150552671 MCL1 -0.33 -5.57 -0.32 6.22e-8 Tonsillectomy; CESC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg08736216 chr1:53307985 ZYG11A 0.34 5.9 0.34 1.08e-8 Monocyte count; CESC cis rs4689388 0.609 rs1046319 chr4:6304286 C/T cg25554036 chr4:6271136 WFS1 0.42 5.56 0.32 6.7e-8 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs3096299 0.967 rs2911253 chr16:89488587 T/G cg08392591 chr16:89556376 ANKRD11 0.44 5.73 0.33 2.77e-8 Multiple myeloma (IgH translocation); CESC cis rs589448 1.000 rs589448 chr12:69752200 A/G cg20891283 chr12:69753455 YEATS4 0.99 17.16 0.73 6.54e-45 Cerebrospinal fluid biomarker levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T ch.22.1008279F chr22:48731367 NA -0.46 -6.35 -0.36 9.18e-10 Gut microbiota (bacterial taxa); CESC cis rs57504626 1 rs57504626 chr19:19720399 C/T cg03709012 chr19:19516395 GATAD2A 0.92 6.36 0.36 9.03e-10 Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg17724175 chr1:150552817 MCL1 0.33 5.08 0.3 7.16e-7 Tonsillectomy; CESC cis rs1801251 0.963 rs35362030 chr2:233612845 A/G cg25237894 chr2:233734115 C2orf82 0.45 7.91 0.44 6.96e-14 Coronary artery disease; CESC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg24531977 chr5:56204891 C5orf35 -0.49 -6.01 -0.35 6.13e-9 Coronary artery disease; CESC cis rs1153858 1.000 rs4774578 chr15:45646051 G/A cg21132104 chr15:45694354 SPATA5L1 0.84 11.4 0.57 9.5e-25 Homoarginine levels; CESC cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg19717773 chr7:2847554 GNA12 -0.54 -8.57 -0.47 8.85e-16 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23597041 chr15:42840898 LRRC57;HAUS2 0.56 6.22 0.36 1.92e-9 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs8079891 chr17:29058863 G/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8060686 0.641 rs9923710 chr16:68224018 C/T cg26727032 chr16:67993705 SLC12A4 -0.51 -6.18 -0.36 2.35e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg04414720 chr1:150670196 GOLPH3L 0.58 7.57 0.42 6.07e-13 Melanoma; CESC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs1200821 0.535 rs1208784 chr10:37768433 A/G cg25427524 chr10:38739819 LOC399744 -0.41 -5.29 -0.31 2.59e-7 Hemostatic factors and hematological phenotypes; CESC cis rs17125944 0.686 rs2357946 chr14:53345266 G/C cg00686598 chr14:53173677 PSMC6 -0.6 -5.24 -0.31 3.3e-7 Alzheimer's disease (late onset); CESC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg14159672 chr1:205819179 PM20D1 0.44 5.73 0.33 2.77e-8 Parkinson's disease; CESC cis rs12681366 0.663 rs2919660 chr8:95470697 C/A cg13257157 chr8:95487014 RAD54B 0.39 5.34 0.31 2.04e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg08499158 chr17:42289980 UBTF 0.42 5.24 0.31 3.22e-7 Total body bone mineral density; CESC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs12325245 0.536 rs35908812 chr16:58587426 T/C cg05725404 chr16:58534157 NDRG4 -0.61 -5.24 -0.31 3.21e-7 Schizophrenia; CESC cis rs754466 0.651 rs7895188 chr10:79623378 C/G cg17075019 chr10:79541650 NA 0.85 13.27 0.63 3.61e-31 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7178572 1.000 rs12904938 chr15:77721225 A/G cg22256960 chr15:77711686 NA -0.59 -7.96 -0.44 5e-14 Type 2 diabetes; CESC cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg08508325 chr11:3079039 CARS -0.58 -10.87 -0.56 5.22e-23 Longevity; CESC cis rs7208859 0.673 rs73263755 chr17:29198972 A/G cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg20476274 chr7:133979776 SLC35B4 0.67 9.8 0.52 1.46e-19 Mean platelet volume; CESC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -10.66 -0.55 2.62e-22 Alzheimer's disease; CESC cis rs30380 0.632 rs27640 chr5:96127905 T/C cg16492584 chr5:96139282 ERAP1 -0.47 -6.59 -0.38 2.33e-10 Cerebrospinal fluid biomarker levels; CESC trans rs1973993 0.967 rs11165643 chr1:96924097 C/T cg10631902 chr5:14652156 NA 0.5 6.71 0.38 1.18e-10 Weight; CESC cis rs9796 0.870 rs2412572 chr15:41264426 G/C cg18705301 chr15:41695430 NDUFAF1 0.43 6.32 0.36 1.12e-9 Menopause (age at onset); CESC trans rs6600671 1.000 rs6600671 chr1:121200490 T/G cg17023122 chr1:144479586 NA -0.49 -6.68 -0.38 1.42e-10 Hip geometry; CESC cis rs5753618 0.539 rs2106294 chr22:31645759 C/T cg13145458 chr22:31556086 RNF185 0.44 5.07 0.3 7.33e-7 Colorectal cancer; CESC trans rs561341 0.883 rs7406056 chr17:30220224 C/T cg27661571 chr11:113659931 NA -0.6 -6.15 -0.35 2.83e-9 Hip circumference adjusted for BMI; CESC cis rs9584850 0.874 rs3742136 chr13:99102607 C/T cg20750642 chr13:99100586 FARP1 -0.38 -5.71 -0.33 3.01e-8 Neuroticism; CESC cis rs61935443 0.666 rs11107780 chr12:95299142 G/A cg21533806 chr12:95267307 NA 0.48 5.22 0.31 3.55e-7 Schizophrenia; CESC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.51 0.37 3.65e-10 Prudent dietary pattern; CESC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs3806843 1.000 rs4404730 chr5:140162610 G/A cg26395211 chr5:140044315 WDR55 -0.43 -5.59 -0.32 5.59e-8 Depressive symptoms (multi-trait analysis); CESC trans rs11039798 0.512 rs3974936 chr11:49005012 C/T cg03929089 chr4:120376271 NA 0.61 6.22 0.36 1.88e-9 Axial length; CESC cis rs2929282 1 rs2929282 chr15:44245931 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.64 5.37 0.31 1.76e-7 Triglycerides;Triglyceride levels; CESC cis rs1509123 0.609 rs75742091 chr17:6703870 C/T cg12642237 chr17:6703447 TEKT1 -0.62 -5.08 -0.3 7.26e-7 Blood metabolite levels; CESC cis rs12586317 0.534 rs1568200 chr14:35419592 C/T cg05294307 chr14:35346193 BAZ1A -0.57 -6.88 -0.39 4.18e-11 Psoriasis; CESC cis rs6087990 0.701 rs1997797 chr20:31387954 C/G cg13636640 chr20:31349939 DNMT3B 0.77 12.28 0.6 9.43e-28 Ulcerative colitis; CESC cis rs12142240 0.698 rs10158572 chr1:46822440 G/T cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs9911578 1.000 rs7207693 chr17:57016525 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -6.83 -0.39 5.73e-11 Intelligence (multi-trait analysis); CESC cis rs208520 0.690 rs2144081 chr6:66824972 G/A cg07460842 chr6:66804631 NA -1.01 -13.46 -0.64 8.19e-32 Exhaled nitric oxide output; CESC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg03576123 chr11:487126 PTDSS2 -1.16 -11.28 -0.57 2.36e-24 Body mass index; CESC cis rs7605827 0.930 rs2111456 chr2:15560118 A/G cg19274914 chr2:15703543 NA 0.35 6.24 0.36 1.72e-9 Educational attainment (years of education); CESC cis rs10197940 0.624 rs13393122 chr2:152413315 A/G cg19508488 chr2:152266495 RIF1 0.48 5.26 0.31 2.96e-7 Lung cancer; CESC cis rs6541297 0.887 rs4846906 chr1:230284257 C/A cg20703242 chr1:230279135 GALNT2 0.65 8.65 0.47 4.89e-16 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19419581 chr17:79482410 NA 0.51 6.43 0.37 5.88e-10 Gut microbiota (bacterial taxa); CESC cis rs11711311 0.668 rs11718061 chr3:113341826 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.49 -6.47 -0.37 4.73e-10 IgG glycosylation; CESC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.43 -0.37 5.97e-10 Bipolar disorder; CESC cis rs6456156 0.586 rs7762156 chr6:167485831 A/T cg07741184 chr6:167504864 NA 0.37 6.28 0.36 1.39e-9 Primary biliary cholangitis; CESC trans rs1728785 0.901 rs1170438 chr16:68608256 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.67 8.16 0.45 1.4e-14 Ulcerative colitis; CESC trans rs57221529 0.766 rs72706610 chr5:561111 G/A cg25482853 chr8:67687455 SGK3 1.12 11.92 0.59 1.58e-26 Lung disease severity in cystic fibrosis; CESC cis rs1707322 0.928 rs7527244 chr1:46368772 A/G cg05343316 chr1:45956843 TESK2 0.43 5.23 0.31 3.41e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg22920501 chr2:26401640 FAM59B -0.78 -9.18 -0.49 1.26e-17 Gut microbiome composition (summer); CESC cis rs9549367 0.713 rs9549691 chr13:113861606 A/C cg18105134 chr13:113819100 PROZ -0.72 -9.0 -0.48 4.5e-17 Platelet distribution width; CESC cis rs6141600 0.760 rs6060794 chr20:34682864 T/C cg07747181 chr20:34652970 NA -0.38 -5.2 -0.3 3.99e-7 Height;Hip circumference; CESC cis rs2367563 1.000 rs8699 chr12:96051883 A/G cg19013339 chr12:96052514 NTN4 0.36 5.09 0.3 6.73e-7 Allergic dermatitis (nickel); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05152629 chr11:207881 BET1L;RIC8A -0.62 -7.18 -0.4 7.22e-12 Gut microbiome composition (summer); CESC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.09 -0.3 6.87e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09737499 chr11:126301004 KIRREL3 -0.41 -6.37 -0.36 8.3e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs6695640 0.820 rs2762891 chr1:17750552 T/C cg01904812 chr1:17746340 RCC2 0.35 5.11 0.3 6.14e-7 Mean platelet volume; CESC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg17971929 chr21:40555470 PSMG1 -0.93 -12.87 -0.62 8.95e-30 Cognitive function; CESC cis rs11083475 0.557 rs2368519 chr19:39259241 C/T cg26703956 chr19:39260304 NA -0.35 -6.7 -0.38 1.23e-10 Heart rate; CESC trans rs708224 0.587 rs184469 chr12:32400298 A/G cg16470816 chr12:58566565 NA 0.37 6.42 0.37 6.33e-10 Pancreatic cancer; CESC cis rs7659604 0.540 rs11934307 chr4:122677514 G/A cg19671926 chr4:122722719 EXOSC9 0.53 6.7 0.38 1.21e-10 Type 2 diabetes; CESC cis rs6831352 0.879 rs29001212 chr4:100051877 T/C cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs6088580 0.634 rs6058073 chr20:33116483 T/C cg24642439 chr20:33292090 TP53INP2 0.51 6.63 0.38 1.89e-10 Glomerular filtration rate (creatinine); CESC cis rs7937682 0.889 rs7948236 chr11:111499933 C/A cg22437258 chr11:111473054 SIK2 0.69 9.07 0.49 2.75e-17 Primary sclerosing cholangitis; CESC cis rs4523957 0.590 rs9899427 chr17:2063550 A/T cg16513277 chr17:2031491 SMG6 -0.69 -9.59 -0.51 6.97e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9486719 1.000 rs4077932 chr6:96905144 C/T cg18709589 chr6:96969512 KIAA0776 -0.54 -5.97 -0.34 7.42e-9 Migraine;Coronary artery disease; CESC cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg02187348 chr16:89574699 SPG7 -0.49 -6.42 -0.37 6.39e-10 Multiple myeloma (IgH translocation); CESC cis rs60154123 0.772 rs664072 chr1:210422160 G/A cg21951975 chr1:209979733 IRF6 0.47 5.92 0.34 9.94e-9 Coronary artery disease; CESC cis rs28489187 0.660 rs3949301 chr1:85863383 G/A cg16011679 chr1:85725395 C1orf52 -0.46 -5.55 -0.32 6.87e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg11836949 chr1:1812359 GNB1 -0.37 -5.21 -0.3 3.88e-7 Body mass index; CESC cis rs7089973 0.604 rs765174 chr10:116601888 C/T cg23260525 chr10:116636907 FAM160B1 0.4 7.2 0.4 6.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg10351095 chr21:47802916 PCNT -0.48 -6.54 -0.37 3.24e-10 Testicular germ cell tumor; CESC cis rs1707322 0.721 rs61784800 chr1:46178112 A/G cg06784218 chr1:46089804 CCDC17 -0.42 -7.58 -0.42 5.82e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6582630 0.598 rs11182207 chr12:38477514 T/C cg26384229 chr12:38710491 ALG10B -0.43 -5.85 -0.34 1.44e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs7264396 0.790 rs6060582 chr20:34313297 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.88 11.93 0.59 1.49e-26 Total cholesterol levels; CESC cis rs1816752 1.000 rs7999554 chr13:25009769 C/A cg02811702 chr13:24901961 NA 0.38 5.62 0.33 4.91e-8 Obesity-related traits; CESC cis rs4780401 0.755 rs2868981 chr16:11765518 T/C cg01061890 chr16:11836724 TXNDC11 -0.39 -5.07 -0.3 7.41e-7 Rheumatoid arthritis; CESC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg24562669 chr7:97807699 LMTK2 0.53 7.91 0.44 7e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs11792861 0.591 rs2282206 chr9:111746267 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.63 9.56 0.51 8.41e-19 Menarche (age at onset); CESC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg06221963 chr1:154839813 KCNN3 -0.68 -11.73 -0.58 7.43e-26 Prostate cancer; CESC cis rs5769707 0.935 rs1109320 chr22:49989106 G/A cg20744362 chr22:50050164 C22orf34 0.41 6.87 0.39 4.66e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg12311346 chr5:56204834 C5orf35 -0.66 -8.0 -0.44 3.92e-14 Initial pursuit acceleration; CESC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.51 -0.32 8.59e-8 Huntington's disease progression; CESC cis rs9660992 0.710 rs1668864 chr1:205248799 T/C cg00857998 chr1:205179979 DSTYK 0.46 5.21 0.3 3.77e-7 Mean corpuscular volume;Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21560157 chr11:71212402 NADSYN1 0.48 6.87 0.39 4.69e-11 Fibrinogen levels; CESC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg06808227 chr14:105710500 BRF1 -0.58 -6.77 -0.38 8.26e-11 Mean platelet volume;Platelet distribution width; CESC cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg10523679 chr1:76189770 ACADM 0.64 6.1 0.35 3.73e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs727505 1.000 rs28523990 chr7:124436139 C/T cg23710748 chr7:124431027 NA -0.48 -7.83 -0.43 1.21e-13 Lewy body disease; CESC cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg04450456 chr4:17643702 FAM184B 0.36 5.04 0.3 8.67e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7827545 0.545 rs6578228 chr8:135562422 G/A cg17885191 chr8:135476712 NA 0.54 5.84 0.34 1.56e-8 Hypertension (SNP x SNP interaction); CESC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg18876405 chr7:65276391 NA 0.69 9.37 0.5 3.34e-18 Aortic root size; CESC cis rs2282802 0.685 rs6889283 chr5:139653439 G/T cg26211634 chr5:139558579 C5orf32 0.52 7.5 0.42 9.6e-13 Intelligence (multi-trait analysis); CESC cis rs15676 0.783 rs10988121 chr9:131564926 A/T cg00228799 chr9:131580591 ENDOG -0.49 -6.09 -0.35 3.93e-9 Blood metabolite levels; CESC cis rs7523050 0.730 rs72984614 chr1:109435848 T/C cg08274380 chr1:109419600 GPSM2 0.91 6.41 0.37 6.51e-10 Fat distribution (HIV); CESC cis rs765787 0.530 rs10467979 chr15:45521270 G/A cg24006582 chr15:45444508 DUOX1 -0.57 -6.88 -0.39 4.36e-11 Uric acid levels; CESC cis rs6493487 0.512 rs71471585 chr15:51262700 C/G cg02338191 chr15:51200825 AP4E1 0.61 5.58 0.32 6.04e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.66 0.43 3.4e-13 Prudent dietary pattern; CESC cis rs1371867 0.846 rs1788182 chr8:101334620 C/T cg11906718 chr8:101322791 RNF19A 0.46 5.91 0.34 1.03e-8 Atrioventricular conduction; CESC cis rs9467711 0.606 rs9379871 chr6:26375854 C/G cg14345882 chr6:26364793 BTN3A2 0.6 5.99 0.35 6.82e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg13607699 chr17:42295918 UBTF -0.49 -5.92 -0.34 9.99e-9 Total body bone mineral density; CESC cis rs962856 0.575 rs632700 chr2:67664874 G/A cg09028215 chr2:67624308 ETAA1 -0.44 -5.36 -0.31 1.84e-7 Pancreatic cancer; CESC cis rs4561483 0.582 rs35063476 chr16:12044301 A/G cg08843971 chr16:11963173 GSPT1 -0.41 -5.39 -0.31 1.55e-7 Testicular germ cell tumor; CESC cis rs1348850 0.872 rs12991272 chr2:178457339 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.93 0.44 6.22e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg26354017 chr1:205819088 PM20D1 0.84 13.1 0.63 1.48e-30 Menarche (age at onset); CESC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.96 -0.34 7.97e-9 Parkinson's disease; CESC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg17372223 chr3:52568218 NT5DC2 0.42 6.4 0.37 7.03e-10 Bipolar disorder; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00734800 chr3:50388182 TUSC4;CYB561D2 0.46 6.21 0.36 2.06e-9 Systemic lupus erythematosus; CESC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.91e-10 Bipolar disorder; CESC trans rs6570726 0.791 rs7765687 chr6:145915100 A/C cg03826317 chr10:25465503 LOC100128811;GPR158 0.3 6.02 0.35 5.89e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs3820928 0.874 rs10210997 chr2:227859108 C/T cg11843606 chr2:227700838 RHBDD1 -0.45 -5.72 -0.33 2.94e-8 Pulmonary function; CESC cis rs1557765 0.527 rs11024272 chr11:17395760 T/C cg15432903 chr11:17409602 KCNJ11 0.43 6.3 0.36 1.23e-9 Body mass index;Social communication problems; CESC cis rs2637266 1.000 rs6480824 chr10:78355705 G/A cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs10791323 0.569 rs10750553 chr11:133740251 T/C cg15485101 chr11:133734466 NA 0.3 5.12 0.3 5.99e-7 Childhood ear infection; CESC cis rs559928 0.606 rs56311067 chr11:63931607 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.84 0.34 1.55e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg26818010 chr10:134567672 INPP5A -0.7 -8.77 -0.47 2.19e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg27121462 chr16:89883253 FANCA -0.71 -10.7 -0.55 1.88e-22 Vitiligo; CESC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg18337363 chr3:52569053 NT5DC2 0.28 5.14 0.3 5.31e-7 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12445461 chr9:6681608 NA -0.42 -6.02 -0.35 5.69e-9 Gambling; CESC cis rs13242816 0.881 rs12706091 chr7:116130783 G/C cg04696780 chr7:116139425 CAV2 -0.61 -5.56 -0.32 6.58e-8 P wave duration; CESC cis rs8038465 0.638 rs12591473 chr15:73967485 A/T cg15420318 chr15:73925796 NPTN 0.49 7.43 0.42 1.54e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9359856 0.623 rs1179903 chr6:90321736 G/T cg13799429 chr6:90582589 CASP8AP2 -0.47 -5.5 -0.32 9.16e-8 Bipolar disorder; CESC cis rs4654899 0.758 rs10218584 chr1:21474480 C/G cg05370193 chr1:21551575 ECE1 -0.36 -5.4 -0.31 1.47e-7 Superior frontal gyrus grey matter volume; CESC trans rs1814175 0.511 rs61905634 chr11:49819736 G/A cg03929089 chr4:120376271 NA -0.91 -15.23 -0.68 4.84e-38 Height; CESC cis rs1355223 0.506 rs7131229 chr11:34869328 A/G cg11622362 chr11:34938112 PDHX;APIP -0.43 -5.08 -0.3 7.07e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg06784218 chr1:46089804 CCDC17 -0.29 -5.07 -0.3 7.56e-7 High light scatter reticulocyte count; CESC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg02564969 chr6:151773285 C6orf211;RMND1 0.6 8.29 0.45 5.79e-15 Menarche (age at onset); CESC cis rs853679 1.000 rs68141011 chr6:28217797 G/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.74 7.3 0.41 3.39e-12 Depression; CESC cis rs7208859 0.623 rs11657369 chr17:29136468 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7587476 0.784 rs13026390 chr2:215687075 C/T cg04004882 chr2:215674386 BARD1 -0.49 -5.53 -0.32 7.73e-8 Neuroblastoma; CESC cis rs1707322 0.963 rs4660900 chr1:46419605 T/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs870825 0.616 rs6552808 chr4:185642865 G/T cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27345282 chr3:196295526 WDR53;FBXO45 -0.44 -6.48 -0.37 4.49e-10 Gambling; CESC cis rs738322 0.718 rs2899297 chr22:38594668 A/G cg25457927 chr22:38595422 NA -0.35 -6.63 -0.38 1.82e-10 Cutaneous nevi; CESC cis rs1163251 0.902 rs640195 chr1:120217650 T/A cg19096424 chr1:120255104 PHGDH 0.43 5.22 0.31 3.62e-7 Blood metabolite levels; CESC cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg06634786 chr22:41940651 POLR3H 0.66 6.98 0.39 2.34e-11 Vitiligo; CESC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg12963246 chr6:28129442 ZNF389 0.55 7.26 0.41 4.27e-12 Depression; CESC cis rs2286503 0.752 rs2286504 chr7:22854847 G/T cg13679077 chr7:22862647 TOMM7 0.51 6.51 0.37 3.78e-10 Fibrinogen; CESC cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg06212747 chr3:49208901 KLHDC8B 0.73 9.73 0.51 2.47e-19 Parkinson's disease; CESC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg22433210 chr17:43662623 NA -0.6 -7.89 -0.44 8.04e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6598955 0.670 rs7522905 chr1:26609259 C/T cg04990556 chr1:26633338 UBXN11 -0.76 -10.79 -0.55 9.37e-23 Obesity-related traits; CESC cis rs1790761 0.587 rs4930431 chr11:67294308 C/T cg23188684 chr11:67383651 NA -0.36 -5.69 -0.33 3.27e-8 Mean corpuscular volume; CESC cis rs2073499 1.000 rs79499880 chr3:50259551 A/G cg05260129 chr3:50388622 TUSC4;CYB561D2 0.7 5.36 0.31 1.84e-7 Schizophrenia; CESC cis rs965469 0.619 rs6037565 chr20:3330308 T/C cg17110299 chr20:3385021 C20orf194 0.4 5.25 0.31 3.1e-7 IFN-related cytopenia; CESC cis rs5758511 0.689 rs56906457 chr22:42628335 A/G cg00645731 chr22:42541494 CYP2D7P1 0.53 7.04 0.4 1.63e-11 Birth weight; CESC cis rs9486719 1.000 rs2971603 chr6:97035418 C/T cg06623918 chr6:96969491 KIAA0776 -0.89 -10.55 -0.54 6.12e-22 Migraine;Coronary artery disease; CESC cis rs7927592 0.913 rs3824850 chr11:68341873 A/G cg20283391 chr11:68216788 NA -0.61 -7.29 -0.41 3.48e-12 Total body bone mineral density; CESC cis rs77741769 0.529 rs7137504 chr12:121221628 C/T cg02419362 chr12:121203948 SPPL3 0.35 5.72 0.33 2.87e-8 Mean corpuscular volume; CESC cis rs6500395 1.000 rs9928051 chr16:48557316 T/A cg04672837 chr16:48644449 N4BP1 0.45 5.11 0.3 6.18e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg10691866 chr7:65817282 TPST1 0.31 5.34 0.31 2e-7 Aortic root size; CESC cis rs5758659 0.714 rs5758589 chr22:42518382 A/G cg19513890 chr22:42538836 CYP2D7P1 0.36 5.28 0.31 2.71e-7 Cognitive function; CESC cis rs116095464 0.558 rs7703803 chr5:292311 A/G cg20965017 chr5:231967 SDHA -0.48 -5.41 -0.32 1.41e-7 Breast cancer; CESC cis rs7917772 0.582 rs7075269 chr10:104365724 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.72 0.33 2.8e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.83 0.39 5.77e-11 Bipolar disorder; CESC cis rs12545109 1.000 rs1975284 chr8:57314663 A/G cg09654669 chr8:57350985 NA -0.52 -6.21 -0.36 2.08e-9 Obesity-related traits; CESC cis rs8060686 0.546 rs8047978 chr16:68143598 T/G cg26727032 chr16:67993705 SLC12A4 -0.59 -8.15 -0.45 1.45e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs6772849 0.930 rs9873888 chr3:128360987 G/A cg16766828 chr3:128327626 NA -0.31 -5.03 -0.3 8.89e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs561341 0.739 rs1978116 chr17:30220978 A/C cg13647721 chr17:30228624 UTP6 0.79 9.88 0.52 8.14e-20 Hip circumference adjusted for BMI; CESC cis rs2933343 0.700 rs1680779 chr3:128614770 G/A cg11901034 chr3:128598214 ACAD9 -0.39 -5.53 -0.32 7.53e-8 IgG glycosylation; CESC cis rs9611565 0.506 rs2024567 chr22:41699206 G/C cg06634786 chr22:41940651 POLR3H -0.51 -5.53 -0.32 7.85e-8 Vitiligo; CESC cis rs820218 0.886 rs2165634 chr17:73663297 T/G cg01592526 chr17:73663357 RECQL5;SAP30BP 0.43 5.52 0.32 7.91e-8 Rotator cuff tears; CESC cis rs9911578 1.000 rs12936058 chr17:57017420 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.9 -0.39 3.85e-11 Intelligence (multi-trait analysis); CESC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg09177884 chr7:1199841 ZFAND2A -0.52 -6.88 -0.39 4.4e-11 Longevity;Endometriosis; CESC cis rs796364 1.000 rs796364 chr2:200716119 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.89 8.75 0.47 2.48e-16 Schizophrenia; CESC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg18135555 chr8:22132992 PIWIL2 0.25 5.48 0.32 1.01e-7 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01949614 chr16:1359397 UBE2I 0.5 6.04 0.35 5.28e-9 Gut microbiome composition (summer); CESC trans rs35110281 0.837 rs2838342 chr21:45077865 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 6.74 0.38 1.01e-10 Mean corpuscular volume; CESC cis rs6141600 0.760 rs2590986 chr20:34686496 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.4 5.31 0.31 2.28e-7 Height;Hip circumference; CESC cis rs9868809 0.772 rs9877501 chr3:48718390 C/G cg06212747 chr3:49208901 KLHDC8B -0.6 -5.18 -0.3 4.36e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg08736216 chr1:53307985 ZYG11A -0.42 -6.78 -0.38 7.89e-11 Monocyte count; CESC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.24 -0.31 3.26e-7 Life satisfaction; CESC cis rs1949733 1.000 rs6837429 chr4:8502374 A/G cg11789530 chr4:8429930 ACOX3 0.76 10.74 0.55 1.45e-22 Response to antineoplastic agents; CESC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg11890956 chr21:40555474 PSMG1 -0.92 -14.5 -0.67 1.81e-35 Cognitive function; CESC cis rs7208859 0.673 rs216435 chr17:28922737 G/T cg04154034 chr17:28927549 LRRC37B2 0.66 5.83 0.34 1.57e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2470135 1 rs2470135 chr15:43995789 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.47 7.13 0.4 9.48e-12 Diastolic blood pressure; CESC cis rs12142240 0.698 rs17357676 chr1:46812444 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.85 0.43 1.05e-13 Menopause (age at onset); CESC cis rs9902453 0.817 rs55758314 chr17:28173978 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.22 0.45 9.05e-15 Coffee consumption (cups per day); CESC cis rs4648845 0.579 rs4592207 chr1:2369498 A/G cg07700843 chr1:2391317 NA -0.37 -6.55 -0.37 2.94e-10 Schizophrenia; CESC cis rs6088580 0.524 rs1321306 chr20:33266379 T/A cg24642439 chr20:33292090 TP53INP2 -0.47 -5.48 -0.32 9.79e-8 Glomerular filtration rate (creatinine); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06285312 chr8:144776160 ZNF707 0.47 6.13 0.35 3.17e-9 Fibrinogen levels; CESC cis rs7845219 0.544 rs6987400 chr8:95921295 T/C cg09323728 chr8:95962352 TP53INP1 -0.32 -6.23 -0.36 1.8e-9 Type 2 diabetes; CESC cis rs698833 0.926 rs786622 chr2:44606598 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 6.56 0.37 2.83e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00832928 chr3:150329458 SELT -0.71 -8.21 -0.45 9.99e-15 Gut microbiome composition (summer); CESC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg06873352 chr17:61820015 STRADA 0.72 12.84 0.62 1.18e-29 Prudent dietary pattern; CESC cis rs6912958 0.712 rs4707383 chr6:88330602 T/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.3 -5.03 -0.3 8.91e-7 Monocyte percentage of white cells; CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg18765753 chr7:1198926 ZFAND2A -0.47 -5.84 -0.34 1.55e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8067545 0.532 rs12449914 chr17:20003969 T/C cg12073167 chr17:19770448 ULK2 -0.44 -5.28 -0.31 2.71e-7 Schizophrenia; CESC cis rs748404 0.660 rs542898 chr15:43719392 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.13 0.45 1.61e-14 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13975730 chr9:139329735 INPP5E 0.45 6.02 0.35 5.78e-9 Fibrinogen levels; CESC cis rs11676348 0.846 rs7607437 chr2:219008392 A/G cg00012203 chr2:219082015 ARPC2 -0.57 -7.18 -0.4 6.85e-12 Ulcerative colitis; CESC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg08109568 chr15:31115862 NA 0.66 9.24 0.49 8.06e-18 Huntington's disease progression; CESC trans rs12265790 1.000 rs11253674 chr10:15929002 T/C cg03460745 chr3:171966142 FNDC3B 0.75 6.02 0.35 5.81e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; CESC cis rs9911578 0.967 rs405684 chr17:56777148 T/C cg12560992 chr17:57184187 TRIM37 0.92 15.4 0.69 1.18e-38 Intelligence (multi-trait analysis); CESC cis rs362272 0.505 rs10155132 chr4:3369500 A/G cg14583973 chr4:3374767 RGS12 0.31 5.54 0.32 7.35e-8 Serum sulfate level; CESC cis rs1707322 0.721 rs12045096 chr1:46114428 A/G cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11608355 0.597 rs2304548 chr12:109795166 T/G cg19025524 chr12:109796872 NA -0.54 -7.99 -0.44 4.03e-14 Neuroticism; CESC cis rs8060686 0.545 rs3815173 chr16:68160289 T/G cg26727032 chr16:67993705 SLC12A4 -0.5 -5.47 -0.32 1.03e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs12142240 0.621 rs13374968 chr1:46843908 T/G cg00530320 chr1:46809349 NSUN4 0.6 8.32 0.46 4.75e-15 Menopause (age at onset); CESC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg26335602 chr6:28129616 ZNF389 0.52 6.84 0.39 5.58e-11 Depression; CESC cis rs763121 0.853 rs3747172 chr22:39067524 A/G cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs68170813 0.559 rs6951639 chr7:106817639 A/G cg02696742 chr7:106810147 HBP1 -0.53 -5.07 -0.3 7.37e-7 Coronary artery disease; CESC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.43 -5.58 -0.32 5.81e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7762018 1.000 rs4509126 chr6:170068058 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.52 5.34 0.31 2e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03574882 chr7:151574332 PRKAG2 0.6 7.18 0.4 7e-12 Gut microbiome composition (summer); CESC cis rs9815354 0.812 rs56728371 chr3:41999381 T/A cg03022575 chr3:42003672 ULK4 0.64 5.69 0.33 3.42e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs11098499 0.954 rs12505469 chr4:120249585 C/T cg24375607 chr4:120327624 NA 0.46 5.64 0.33 4.35e-8 Corneal astigmatism; CESC cis rs12477438 0.520 rs2964969 chr2:99782811 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.41 0.69 1.09e-38 Chronic sinus infection; CESC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.26 -0.49 7.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg07701084 chr6:150067640 NUP43 0.43 5.85 0.34 1.45e-8 Lung cancer; CESC cis rs10751667 0.666 rs7123912 chr11:963936 T/C cg06064525 chr11:970664 AP2A2 -0.47 -9.32 -0.5 4.88e-18 Alzheimer's disease (late onset); CESC cis rs367943 0.799 rs2115209 chr5:112973494 A/G cg12552261 chr5:112820674 MCC 0.54 6.14 0.35 3.08e-9 Type 2 diabetes; CESC cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.47 0.46 1.72e-15 Colonoscopy-negative controls vs population controls; CESC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg18876405 chr7:65276391 NA -0.54 -7.11 -0.4 1.11e-11 Aortic root size; CESC cis rs10504229 0.813 rs6999878 chr8:58197243 C/G cg24829409 chr8:58192753 C8orf71 -0.44 -5.67 -0.33 3.65e-8 Developmental language disorder (linguistic errors); CESC cis rs4076764 0.914 rs4638099 chr1:163365521 A/G cg06092702 chr1:163392909 NA 0.44 6.49 0.37 4.29e-10 Motion sickness; CESC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg04369109 chr6:150039330 LATS1 -0.39 -5.27 -0.31 2.82e-7 Lung cancer; CESC cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg10556349 chr10:835070 NA 0.57 5.47 0.32 1.04e-7 Eosinophil percentage of granulocytes; CESC cis rs17039065 0.920 rs73838432 chr4:109434153 A/C cg16022748 chr4:109541635 LOC285456;RPL34 0.62 5.17 0.3 4.7e-7 Gut microbiome composition (summer); CESC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg00802000 chr16:706648 WDR90 -0.4 -6.06 -0.35 4.57e-9 Height; CESC cis rs28647808 1.000 rs4962142 chr9:136274883 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs56046484 0.956 rs35204319 chr15:85650477 C/T cg08123816 chr15:85640762 PDE8A -0.44 -5.31 -0.31 2.29e-7 Testicular germ cell tumor; CESC cis rs1008375 0.966 rs4698636 chr4:17632834 T/C cg02297831 chr4:17616191 MED28 0.55 6.95 0.39 2.82e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26667821 chr1:155099774 EFNA1 0.48 6.34 0.36 9.84e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg26116260 chr4:7069785 GRPEL1 -0.86 -8.98 -0.48 5.25e-17 Monocyte percentage of white cells; CESC cis rs8072100 0.817 rs7213086 chr17:45752310 C/G cg08085267 chr17:45401833 C17orf57 -0.4 -5.04 -0.3 8.76e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs5753618 0.539 rs5753596 chr22:31787472 C/T cg13145458 chr22:31556086 RNF185 0.45 5.57 0.32 6.29e-8 Colorectal cancer; CESC cis rs11190604 0.697 rs12355942 chr10:102201320 T/C cg07080220 chr10:102295463 HIF1AN -0.53 -5.38 -0.31 1.66e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs10870270 0.956 rs10430618 chr10:133748996 C/T cg08754478 chr10:133766260 PPP2R2D -0.61 -7.93 -0.44 6.27e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7577696 0.568 rs462878 chr2:32438655 A/G cg02381751 chr2:32503542 YIPF4 0.46 5.16 0.3 4.77e-7 Inflammatory biomarkers; CESC trans rs3942852 0.868 rs7118232 chr11:48106274 T/C cg03929089 chr4:120376271 NA -0.56 -6.13 -0.35 3.19e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.72 -0.38 1.1e-10 Developmental language disorder (linguistic errors); CESC cis rs6582630 0.555 rs11181684 chr12:38388000 T/C cg26384229 chr12:38710491 ALG10B 0.69 10.49 0.54 8.95e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs9457247 0.967 rs402191 chr6:167405553 T/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.54 -0.46 1.09e-15 Crohn's disease; CESC cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg21573476 chr21:45109991 RRP1B -0.48 -6.66 -0.38 1.61e-10 Mean corpuscular volume; CESC cis rs6740322 0.895 rs10172375 chr2:43572047 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -7.14 -0.4 8.99e-12 Coronary artery disease; CESC cis rs35955747 0.934 rs5994397 chr22:31826150 G/C cg25791279 chr22:32026902 PISD -0.44 -5.29 -0.31 2.53e-7 Neutrophil count;Sum basophil neutrophil counts; CESC trans rs8073060 0.586 rs4796104 chr17:34046832 T/C cg19694781 chr19:47549865 TMEM160 0.72 6.47 0.37 4.78e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs9457247 0.935 rs401260 chr6:167405888 T/C cg07741184 chr6:167504864 NA 0.29 5.31 0.31 2.32e-7 Crohn's disease; CESC cis rs3020736 0.500 rs2839708 chr22:42500745 A/G cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg08736216 chr1:53307985 ZYG11A 0.32 5.72 0.33 2.87e-8 Monocyte count; CESC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg00106254 chr7:1943704 MAD1L1 -0.51 -6.34 -0.36 9.84e-10 Bipolar disorder and schizophrenia; CESC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg08736216 chr1:53307985 ZYG11A -0.38 -6.0 -0.35 6.43e-9 Monocyte count; CESC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg06481639 chr22:41940642 POLR3H 0.59 5.84 0.34 1.51e-8 Vitiligo; CESC cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg21573476 chr21:45109991 RRP1B -0.5 -6.94 -0.39 3.09e-11 Mean corpuscular volume; CESC cis rs7824557 0.564 rs2736301 chr8:11236413 C/T cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.52e-14 Retinal vascular caliber; CESC cis rs11997175 0.545 rs7818001 chr8:33807682 G/T ch.8.33884649F chr8:33765107 NA 0.47 6.0 0.35 6.54e-9 Body mass index; CESC cis rs12220238 0.818 rs115350439 chr10:75899365 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.63 6.15 0.35 2.9e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg25934064 chr3:52569026 NT5DC2 0.26 5.31 0.31 2.27e-7 Electroencephalogram traits; CESC cis rs763121 0.925 rs5750654 chr22:39051428 T/C cg06022373 chr22:39101656 GTPBP1 0.9 15.29 0.68 2.79e-38 Menopause (age at onset); CESC cis rs4568518 0.619 rs9648238 chr7:18005237 A/G cg03009463 chr7:17980271 SNX13 0.42 5.54 0.32 7.18e-8 Measles; CESC trans rs79976124 0.842 rs1548154 chr6:66624910 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 8.36 0.46 3.49e-15 Type 2 diabetes; CESC cis rs6728642 0.561 rs58984980 chr2:97570759 T/A cg26665480 chr2:98280029 ACTR1B -0.58 -5.22 -0.31 3.69e-7 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs2200578 1.000 rs2200578 chr2:99876244 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.48 5.11 0.3 6.16e-7 IgG glycosylation; CESC cis rs597539 0.690 rs615644 chr11:68621806 G/C cg01988459 chr11:68622903 NA -0.4 -5.22 -0.31 3.62e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs936229 0.749 rs7497201 chr15:75190690 A/G cg10253484 chr15:75165896 SCAMP2 -0.44 -5.03 -0.3 9.07e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg10691866 chr7:65817282 TPST1 0.32 5.42 0.32 1.35e-7 Aortic root size; CESC cis rs4722585 0.764 rs4259314 chr7:26182214 A/G cg07876897 chr7:26191696 NFE2L3 -0.42 -5.42 -0.32 1.31e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); CESC cis rs36051895 0.632 rs10974979 chr9:5131731 C/A cg02405213 chr9:5042618 JAK2 -0.49 -5.86 -0.34 1.35e-8 Pediatric autoimmune diseases; CESC cis rs8058578 1.000 rs3747481 chr16:30666367 C/T cg00531865 chr16:30841666 NA -0.43 -5.56 -0.32 6.6e-8 Multiple myeloma; CESC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.08 0.3 7.02e-7 Personality dimensions; CESC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg11965913 chr1:205819406 PM20D1 0.47 7.11 0.4 1.05e-11 Menarche (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09235050 chr20:57599210 TUBB1 0.5 7.36 0.41 2.29e-12 Fibrinogen levels; CESC cis rs7786808 0.705 rs1377373 chr7:158215549 A/C cg09998033 chr7:158218633 PTPRN2 0.46 7.05 0.4 1.51e-11 Obesity-related traits; CESC cis rs6545883 0.859 rs13004855 chr2:61505072 C/T cg15711740 chr2:61764176 XPO1 0.39 5.05 0.3 8.17e-7 Tuberculosis; CESC cis rs3820928 1.000 rs3820928 chr2:227773466 A/G cg05526886 chr2:227700861 RHBDD1 -0.4 -5.34 -0.31 2.05e-7 Pulmonary function; CESC cis rs938554 0.736 rs13125646 chr4:9982330 A/G cg11266682 chr4:10021025 SLC2A9 0.37 5.09 0.3 6.89e-7 Blood metabolite levels; CESC cis rs1775715 0.870 rs1775731 chr10:32253512 A/G cg18675610 chr10:32216311 ARHGAP12 0.33 5.14 0.3 5.37e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4319547 0.695 rs4758662 chr12:122924778 G/A cg05707623 chr12:122985044 ZCCHC8 -0.54 -6.14 -0.35 2.93e-9 Body mass index; CESC cis rs317689 0.718 rs315130 chr12:69761444 T/C cg14784868 chr12:69753453 YEATS4 0.64 7.44 0.42 1.36e-12 Response to diuretic therapy; CESC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg26335602 chr6:28129616 ZNF389 0.37 5.29 0.31 2.58e-7 Parkinson's disease; CESC cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs863345 0.604 rs2054993 chr1:158505968 T/G cg12129480 chr1:158549410 OR10X1 -0.33 -6.61 -0.38 2.11e-10 Pneumococcal bacteremia; CESC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs77106637 0.858 rs117819392 chr11:72514503 C/T cg04827223 chr11:72435913 ARAP1 -0.57 -5.82 -0.34 1.67e-8 Type 2 diabetes; CESC cis rs9916302 0.718 rs7219909 chr17:37706243 C/T cg00129232 chr17:37814104 STARD3 -0.57 -7.46 -0.42 1.22e-12 Glomerular filtration rate (creatinine); CESC cis rs11760633 0.672 rs12669620 chr7:1826878 G/C cg23422044 chr7:1970798 MAD1L1 -0.44 -5.26 -0.31 3.02e-7 Coronary artery disease; CESC cis rs225245 0.791 rs2285742 chr17:34018682 C/T cg05299278 chr17:33885742 SLFN14 0.4 5.6 0.33 5.35e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg11764359 chr7:65958608 NA 0.96 15.06 0.68 1.89e-37 Aortic root size; CESC cis rs17376456 0.825 rs10064368 chr5:93266396 C/A cg25358565 chr5:93447407 FAM172A 1.12 10.4 0.54 1.88e-21 Diabetic retinopathy; CESC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg10351095 chr21:47802916 PCNT -0.5 -6.86 -0.39 4.96e-11 Testicular germ cell tumor; CESC cis rs2274273 0.624 rs8005450 chr14:55799165 A/T cg04306507 chr14:55594613 LGALS3 0.29 5.11 0.3 6.15e-7 Protein biomarker; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18707867 chr19:3971272 DAPK3 0.54 6.01 0.35 6.08e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02986938 chr1:174968958 CACYBP -0.45 -6.11 -0.35 3.51e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3096299 0.781 rs2965819 chr16:89501030 G/T cg02187348 chr16:89574699 SPG7 -0.56 -7.45 -0.42 1.29e-12 Multiple myeloma (IgH translocation); CESC cis rs3762637 1.000 rs9867429 chr3:122232668 T/C cg24169773 chr3:122142474 KPNA1 -0.6 -6.97 -0.39 2.53e-11 LDL cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20121920 chr12:124833935 NCOR2 -0.5 -6.45 -0.37 5.19e-10 Gut microbiome composition (summer); CESC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg24562669 chr7:97807699 LMTK2 0.47 6.61 0.38 2.13e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs2230307 0.536 rs700533 chr1:100483822 A/G cg24955406 chr1:100503596 HIAT1 0.54 5.44 0.32 1.19e-7 Carotid intima media thickness; CESC cis rs6089584 0.526 rs6089619 chr20:60610916 C/T cg06108461 chr20:60628389 TAF4 -0.59 -7.88 -0.44 8.57e-14 Body mass index; CESC cis rs921968 0.509 rs626432 chr2:219355658 C/A cg02176678 chr2:219576539 TTLL4 0.51 9.13 0.49 1.86e-17 Mean corpuscular hemoglobin concentration; CESC cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg25405998 chr7:65216604 CCT6P1 0.51 5.53 0.32 7.63e-8 Aortic root size; CESC cis rs4132509 0.793 rs10803161 chr1:243990770 T/C cg21452805 chr1:244014465 NA 0.51 6.35 0.36 9.47e-10 RR interval (heart rate); CESC cis rs2637266 0.756 rs846609 chr10:78551718 A/G cg18941641 chr10:78392320 NA 0.41 7.93 0.44 6.26e-14 Pulmonary function; CESC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg13902645 chr11:5959945 NA -0.67 -9.11 -0.49 2.14e-17 DNA methylation (variation); CESC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg23018236 chr17:30244563 NA -0.52 -5.59 -0.32 5.65e-8 Hip circumference adjusted for BMI; CESC trans rs6677604 1.000 rs7519758 chr1:196825287 C/T cg02859443 chr16:53737878 RPGRIP1L;FTO -0.62 -6.07 -0.35 4.34e-9 IgA nephropathy;Nephropathy;Blood protein levels; CESC cis rs10411936 1.000 rs11878602 chr19:16555153 A/C cg10248733 chr19:16607483 C19orf44;CALR3 -0.45 -5.4 -0.31 1.48e-7 White blood cell count;Multiple sclerosis; CESC trans rs12659622 0.703 rs17602097 chr5:15688927 C/T cg22457238 chr19:58570995 ZNF135 -0.49 -6.25 -0.36 1.59e-9 Obesity-related traits; CESC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs916888 0.773 rs538628 chr17:44787313 G/C cg27589368 chr17:43923255 LOC100128977;IMP5 -0.38 -5.25 -0.31 3.06e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs61931739 0.500 rs1843736 chr12:34012080 C/G cg26384229 chr12:38710491 ALG10B 0.59 8.21 0.45 9.45e-15 Morning vs. evening chronotype; CESC cis rs1256061 0.603 rs10148269 chr14:64736924 A/G cg21174375 chr14:64681225 SYNE2 0.51 6.82 0.39 6.15e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18052878 chr11:61276087 LRRC10B 0.53 6.02 0.35 5.89e-9 Gut microbiome composition (summer); CESC cis rs2531992 1.000 rs2531992 chr16:4021734 A/G cg05927578 chr16:4029543 ADCY9 0.44 5.5 0.32 8.93e-8 Waist circumference; CESC cis rs7116495 0.609 rs7115513 chr11:71664495 T/A cg07596299 chr11:71824057 C11orf51 -0.76 -5.21 -0.3 3.85e-7 Severe influenza A (H1N1) infection; CESC cis rs3015497 0.789 rs10133849 chr14:51121700 A/G cg09863266 chr14:51125203 SAV1 -0.36 -5.71 -0.33 3e-8 Mean platelet volume; CESC cis rs473651 0.935 rs559579 chr2:239339501 G/C cg18131467 chr2:239335373 ASB1 0.94 14.13 0.66 3.57e-34 Multiple system atrophy; CESC cis rs4474465 0.833 rs11606128 chr11:78156960 T/C cg27205649 chr11:78285834 NARS2 -0.41 -5.16 -0.3 4.79e-7 Alzheimer's disease (survival time); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg20641355 chr8:90992387 NBN 0.39 6.14 0.35 3.03e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs72945132 0.825 rs72947052 chr11:70188575 A/G cg00319359 chr11:70116639 PPFIA1 0.76 6.19 0.36 2.3e-9 Coronary artery disease; CESC cis rs2295499 0.700 rs59425183 chr4:2721199 G/A cg08330972 chr4:2403930 ZFYVE28 -0.33 -5.53 -0.32 7.5e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs1387259 0.929 rs2956703 chr12:48670294 C/T cg04545296 chr12:48745243 ZNF641 0.42 7.06 0.4 1.47e-11 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs6484504 0.576 rs441975 chr11:31233351 C/T cg14844989 chr11:31128820 NA -0.43 -6.12 -0.35 3.26e-9 Red blood cell count; CESC cis rs12621445 1 rs12621445 chr2:24154964 C/T cg08917208 chr2:24149416 ATAD2B 1.12 10.14 0.53 1.21e-20 Immature fraction of reticulocytes; CESC cis rs4629180 0.675 rs908132 chr2:102093096 A/G cg21388029 chr2:102003306 CREG2 0.32 5.04 0.3 8.68e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs10870270 1.000 rs72636963 chr10:133771271 C/T cg26149184 chr10:133730230 NA 0.38 5.16 0.3 4.87e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7116495 0.609 rs6592457 chr11:71738086 G/C cg10381502 chr11:71823885 C11orf51 -1.16 -6.94 -0.39 3.1e-11 Severe influenza A (H1N1) infection; CESC cis rs1832871 0.655 rs6920121 chr6:158678504 C/T cg07165851 chr6:158734300 TULP4 -0.58 -6.32 -0.36 1.12e-9 Height; CESC cis rs2295499 0.782 rs4690053 chr4:2736579 G/C cg27239842 chr4:2403781 ZFYVE28 -0.32 -5.15 -0.3 5.12e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg02896835 chr1:92012615 NA 0.49 6.42 0.37 6.41e-10 Breast cancer; CESC cis rs11718455 0.767 rs4682924 chr3:43992760 G/A cg08738300 chr3:44038990 NA 0.44 5.86 0.34 1.34e-8 Coronary artery disease; CESC cis rs3762637 1.000 rs12633461 chr3:122135897 C/G cg24169773 chr3:122142474 KPNA1 -0.51 -6.03 -0.35 5.56e-9 LDL cholesterol levels; CESC cis rs60843830 1.000 rs7566279 chr2:281178 C/G cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.15 0.53 1.14e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs8020095 0.528 rs6573758 chr14:67667906 A/G cg19548862 chr14:67692701 FAM71D -0.47 -5.75 -0.33 2.39e-8 Depression (quantitative trait); CESC cis rs6088580 0.634 rs6059779 chr20:32950325 C/T cg06115741 chr20:33292138 TP53INP2 -0.44 -5.7 -0.33 3.14e-8 Glomerular filtration rate (creatinine); CESC cis rs7512552 0.839 rs2264418 chr1:150368579 G/A cg15654264 chr1:150340011 RPRD2 0.4 5.28 0.31 2.65e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs782590 0.967 rs1823893 chr2:55788921 T/C cg18811423 chr2:55921094 PNPT1 0.77 12.37 0.6 4.82e-28 Metabolic syndrome; CESC cis rs7937682 0.575 rs7107213 chr11:111750430 A/G cg22437258 chr11:111473054 SIK2 -0.45 -5.05 -0.3 8.14e-7 Primary sclerosing cholangitis; CESC cis rs10924970 0.624 rs12755851 chr1:235477806 G/C cg26050004 chr1:235667680 B3GALNT2 0.44 5.1 0.3 6.52e-7 Asthma; CESC cis rs7639513 0.767 rs9878151 chr3:12703714 G/C cg23032965 chr3:12705835 RAF1 0.76 10.61 0.55 3.68e-22 Itch intensity from mosquito bite; CESC cis rs2072732 0.808 rs74048148 chr1:2954031 A/G cg15211996 chr1:2936768 ACTRT2 0.35 6.02 0.35 5.76e-9 Plateletcrit; CESC trans rs7824557 0.527 rs2572449 chr8:11239137 A/G cg15556689 chr8:8085844 FLJ10661 0.49 6.28 0.36 1.38e-9 Retinal vascular caliber; CESC cis rs9487051 0.714 rs7744284 chr6:109616218 C/T cg12927641 chr6:109611667 NA -0.36 -5.36 -0.31 1.83e-7 Reticulocyte fraction of red cells; CESC cis rs9815354 0.767 rs73830585 chr3:42003698 T/A cg03022575 chr3:42003672 ULK4 0.66 5.77 0.33 2.17e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.22 0.31 3.62e-7 Menopause (age at onset); CESC cis rs208520 0.690 rs851458 chr6:66813279 T/G cg07460842 chr6:66804631 NA -0.98 -13.55 -0.64 3.82e-32 Exhaled nitric oxide output; CESC cis rs7605827 0.930 rs11682580 chr2:15533272 T/C cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs36093924 0.646 rs5996092 chr22:42344408 A/G cg15557168 chr22:42548783 NA 0.37 5.39 0.31 1.57e-7 Intelligence; CESC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg11494091 chr17:61959527 GH2 0.73 12.58 0.61 8.77e-29 Prudent dietary pattern; CESC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.12e-10 Bipolar disorder; CESC cis rs7833986 0.501 rs2976038 chr8:57028864 G/A cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.41 0.32 1.42e-7 Height; CESC cis rs2439831 1.000 rs2254321 chr15:43707542 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.79 11.67 0.58 1.11e-25 Lung cancer in ever smokers; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12565914 chr11:47270322 ACP2;NR1H3 0.49 6.19 0.36 2.29e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9911578 0.933 rs2632508 chr17:56533235 G/A cg12560992 chr17:57184187 TRIM37 0.91 15.16 0.68 8.27e-38 Intelligence (multi-trait analysis); CESC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg12419862 chr22:24373484 LOC391322 -0.7 -9.61 -0.51 6.14e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7927592 0.956 rs10896334 chr11:68281494 C/T cg20283391 chr11:68216788 NA -0.5 -5.99 -0.35 6.77e-9 Total body bone mineral density; CESC cis rs1190552 0.846 rs3783382 chr14:102965437 A/T cg18135206 chr14:102964638 TECPR2 0.42 5.32 0.31 2.22e-7 Blood protein levels; CESC cis rs55665837 0.559 rs11023210 chr11:14422762 A/G cg19336497 chr11:14380999 RRAS2 0.35 5.16 0.3 4.9e-7 Vitamin D levels; CESC cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg03467027 chr4:99064603 C4orf37 0.41 5.63 0.33 4.48e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9303401 0.632 rs9915267 chr17:57244907 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.56 7.14 0.4 9.15e-12 Cognitive test performance; CESC trans rs7615952 0.932 rs11922218 chr3:125631289 C/T cg07211511 chr3:129823064 LOC729375 -1.07 -14.34 -0.66 6.43e-35 Blood pressure (smoking interaction); CESC cis rs6456156 0.586 rs2001115 chr6:167486218 A/C cg23791538 chr6:167370224 RNASET2 -0.5 -6.37 -0.36 8.51e-10 Primary biliary cholangitis; CESC cis rs2235642 0.717 rs9937922 chr16:1658154 C/G cg03715980 chr16:1756201 MAPK8IP3 0.42 5.61 0.33 5.02e-8 Coronary artery disease; CESC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg19622623 chr12:86230825 RASSF9 -0.47 -6.05 -0.35 4.94e-9 Major depressive disorder; CESC trans rs11039798 0.588 rs12294395 chr11:48476860 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.84 0.39 5.37e-11 Axial length; CESC trans rs9354308 0.899 rs2814099 chr6:66555130 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.63 7.03 0.4 1.75e-11 Metabolite levels; CESC cis rs8180040 0.966 rs7651762 chr3:47470484 G/A cg27129171 chr3:47204927 SETD2 -0.63 -9.64 -0.51 4.71e-19 Colorectal cancer; CESC trans rs55704346 0.566 rs2292408 chr4:25394078 A/G cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg06873352 chr17:61820015 STRADA 0.72 12.74 0.62 2.58e-29 Prudent dietary pattern; CESC cis rs4253772 0.637 rs6008339 chr22:46650846 C/T cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.48 5.11 0.3 6.16e-7 LDL cholesterol;Cholesterol, total; CESC cis rs8002861 0.905 rs12875052 chr13:44449368 G/C cg14210620 chr13:44453864 C13orf31;CCDC122 -0.44 -5.49 -0.32 9.44e-8 Leprosy; CESC cis rs4253772 0.550 rs9615951 chr22:46728056 C/A cg18190219 chr22:46762943 CELSR1 -0.62 -6.51 -0.37 3.73e-10 LDL cholesterol;Cholesterol, total; CESC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.08e-10 Bipolar disorder; CESC cis rs12477438 0.520 rs2516835 chr2:99779131 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.84 0.62 1.16e-29 Chronic sinus infection; CESC trans rs9388451 0.626 rs3799712 chr6:126075103 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.66 -9.3 -0.5 5.38e-18 Brugada syndrome; CESC cis rs7818688 0.697 rs17665737 chr8:95986306 A/G cg16049864 chr8:95962084 TP53INP1 0.58 5.71 0.33 2.99e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs6540559 0.543 rs664097 chr1:210422179 C/T cg25204440 chr1:209979598 IRF6 0.47 5.31 0.31 2.33e-7 Cleft lip with or without cleft palate; CESC cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.78 8.92 0.48 7.63e-17 Alzheimer's disease; CESC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg25036284 chr2:26402008 FAM59B 0.86 9.36 0.5 3.44e-18 Gut microbiome composition (summer); CESC cis rs7089973 0.624 rs10885613 chr10:116589400 G/A cg25233709 chr10:116636983 FAM160B1 0.38 5.9 0.34 1.12e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7208859 0.623 rs56018041 chr17:29059985 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs1814175 0.817 rs1818890 chr11:49856882 T/C cg03929089 chr4:120376271 NA -0.91 -15.11 -0.68 1.3e-37 Height; CESC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.27 -0.31 2.78e-7 Lung cancer; CESC cis rs72781680 0.752 rs12616649 chr2:23890913 G/A cg08917208 chr2:24149416 ATAD2B 1.18 10.39 0.54 1.89e-21 Lymphocyte counts; CESC cis rs977987 0.806 rs1544810 chr16:75411163 A/T cg03315344 chr16:75512273 CHST6 0.4 5.72 0.33 2.88e-8 Dupuytren's disease; CESC cis rs2243480 1.000 rs316315 chr7:65591205 C/T cg13147721 chr7:65941812 NA 0.8 8.67 0.47 4.4e-16 Diabetic kidney disease; CESC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.48 0.32 9.87e-8 Electroencephalogram traits; CESC cis rs6088580 0.524 rs2378251 chr20:33276750 C/T cg08999081 chr20:33150536 PIGU -0.43 -6.18 -0.35 2.44e-9 Glomerular filtration rate (creatinine); CESC cis rs360798 0.512 rs2710637 chr2:63173450 G/A cg17519650 chr2:63277830 OTX1 0.52 6.63 0.38 1.87e-10 Coronary artery disease; CESC cis rs300703 0.515 rs364431 chr2:191399 C/A cg21211680 chr2:198530 NA 0.91 10.48 0.54 1e-21 Blood protein levels; CESC cis rs2066819 1.000 rs74496027 chr12:56726340 C/T cg26734620 chr12:56694298 CS 0.98 5.95 0.34 8.45e-9 Psoriasis vulgaris; CESC cis rs1927790 0.727 rs4771932 chr13:96950542 G/A cg02571835 chr13:96230311 CLDN10 -0.36 -5.11 -0.3 6.13e-7 Body mass index; CESC cis rs6963495 0.818 rs55691539 chr7:105165774 T/C cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs9660992 0.710 rs1668867 chr1:205240251 C/T cg00857998 chr1:205179979 DSTYK 0.46 5.4 0.31 1.51e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs9908102 0.770 rs73298508 chr17:12904223 A/G cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs4450798 0.602 rs4431090 chr3:13791700 A/C cg23332027 chr3:13681764 NA 0.4 5.52 0.32 8.21e-8 Bipolar disorder with mood-incongruent psychosis; CESC trans rs11764590 0.694 rs11773643 chr7:2104063 A/G cg11693508 chr17:37793320 STARD3 0.54 6.1 0.35 3.8e-9 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22459051 chr7:44058729 POLR2J4 -0.58 -6.32 -0.36 1.13e-9 Gut microbiome composition (summer); CESC cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 6.89 0.39 3.98e-11 Colorectal cancer; CESC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.16 -0.3 4.76e-7 Developmental language disorder (linguistic errors); CESC cis rs35160687 0.644 rs11680025 chr2:86545338 C/T cg01119172 chr2:86362222 SNORD94;PTCD3 -0.38 -5.29 -0.31 2.57e-7 Night sleep phenotypes; CESC cis rs72949976 0.864 rs10176806 chr2:214022596 T/G cg08319019 chr2:214017104 IKZF2 -0.46 -5.7 -0.33 3.2e-8 Lung cancer;Squamous cell lung carcinoma; CESC cis rs9611565 0.559 rs5751160 chr22:42175695 A/G cg06481639 chr22:41940642 POLR3H 0.59 5.76 0.33 2.35e-8 Vitiligo; CESC cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.35 5.08 0.3 7.22e-7 Schizophrenia; CESC cis rs2658782 0.724 rs1869914 chr11:93112492 C/G cg15737290 chr11:93063684 CCDC67 0.53 6.9 0.39 3.81e-11 Pulmonary function decline; CESC trans rs4332037 0.851 rs28728306 chr7:1961814 C/A cg11693508 chr17:37793320 STARD3 0.7 6.8 0.39 7e-11 Bipolar disorder; CESC cis rs2070488 0.699 rs13078966 chr3:38517914 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 13.35 0.63 2.01e-31 Electrocardiographic conduction measures; CESC cis rs7100689 0.577 rs9420349 chr10:82031160 T/C cg00277334 chr10:82204260 NA -0.51 -6.6 -0.38 2.28e-10 Post bronchodilator FEV1; CESC cis rs2625529 0.730 rs2957373 chr15:72340929 T/C cg16672083 chr15:72433130 SENP8 0.43 6.37 0.36 8.26e-10 Red blood cell count; CESC cis rs12142240 0.698 rs72890727 chr1:46860237 G/A cg00530320 chr1:46809349 NSUN4 0.6 8.27 0.45 6.54e-15 Menopause (age at onset); CESC cis rs3733585 0.699 rs17245723 chr4:9962218 A/T cg11266682 chr4:10021025 SLC2A9 -0.6 -11.15 -0.57 6.33e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9837602 1.000 rs2291495 chr3:99782227 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.5 7.11 0.4 1.1e-11 Breast cancer; CESC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg23161317 chr6:28129485 ZNF389 0.53 6.4 0.37 7.05e-10 Parkinson's disease; CESC cis rs8072100 0.667 rs1912485 chr17:45515678 T/G cg25173405 chr17:45401733 C17orf57 -0.43 -5.43 -0.32 1.26e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs561341 0.714 rs111760509 chr17:30304320 A/G cg27661571 chr11:113659931 NA -0.82 -7.68 -0.43 3.16e-13 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21959316 chr1:85040158 CTBS 0.67 7.43 0.42 1.54e-12 Gut microbiome composition (summer); CESC cis rs79349575 0.783 rs4793998 chr17:47019899 C/T cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg18225595 chr11:63971243 STIP1 -0.48 -6.72 -0.38 1.13e-10 Platelet count; CESC cis rs9902453 0.765 rs2259857 chr17:28097780 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.41 -0.54 1.71e-21 Coffee consumption (cups per day); CESC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg06221963 chr1:154839813 KCNN3 -0.66 -11.39 -0.57 1.03e-24 Prostate cancer; CESC cis rs17253792 0.822 rs10147431 chr14:56091841 G/A cg01858014 chr14:56050164 KTN1 -0.83 -7.03 -0.4 1.7e-11 Putamen volume; CESC cis rs1801251 1.000 rs778166 chr2:233664097 A/T cg08000102 chr2:233561755 GIGYF2 0.67 9.77 0.51 1.93e-19 Coronary artery disease; CESC cis rs72901758 0.768 rs11657271 chr17:76249682 A/T cg26068271 chr17:76253126 NA 0.44 6.45 0.37 5.4e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg21724239 chr8:58056113 NA 0.6 5.56 0.32 6.59e-8 Developmental language disorder (linguistic errors); CESC cis rs1568889 0.941 rs35357280 chr11:28322745 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 7.67 0.43 3.3e-13 Bipolar disorder; CESC cis rs11711311 1.000 rs9809850 chr3:113429010 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.66 8.98 0.48 5.02e-17 IgG glycosylation; CESC cis rs8114671 0.562 rs4911163 chr20:33470694 C/T cg07148914 chr20:33460835 GGT7 0.46 6.11 0.35 3.46e-9 Height; CESC cis rs3750965 0.920 rs10896421 chr11:68863048 T/C cg01403660 chr11:68851641 TPCN2 0.4 5.48 0.32 9.89e-8 Hair color; CESC cis rs7666738 0.830 rs62318470 chr4:98925846 A/C cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs3820928 0.904 rs4439949 chr2:227764954 T/G cg05526886 chr2:227700861 RHBDD1 -0.44 -5.55 -0.32 6.93e-8 Pulmonary function; CESC cis rs7116495 1.000 rs2298456 chr11:71730715 A/T cg26138937 chr11:71823887 C11orf51 0.76 6.47 0.37 4.63e-10 Severe influenza A (H1N1) infection; CESC cis rs854765 0.647 rs854763 chr17:18010095 C/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.0 0.35 6.41e-9 Total body bone mineral density; CESC cis rs6963495 0.538 rs55967123 chr7:105163678 C/A cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs4253772 0.575 rs9615979 chr22:46789021 G/T cg09491104 chr22:46646882 C22orf40 -0.55 -5.04 -0.3 8.54e-7 LDL cholesterol;Cholesterol, total; CESC cis rs3812762 0.912 rs4929936 chr11:8792622 C/T cg03980550 chr11:8754370 ST5 -0.39 -5.33 -0.31 2.12e-7 Hypospadias; CESC cis rs67478160 0.654 rs4906365 chr14:104229230 G/C cg08213375 chr14:104286397 PPP1R13B 0.55 10.87 0.56 5.17e-23 Schizophrenia; CESC cis rs807669 0.505 rs28651174 chr22:19236489 C/T cg02655711 chr22:19163373 SLC25A1 0.41 6.01 0.35 6.26e-9 Metabolite levels; CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg01238044 chr22:24384105 GSTT1 -0.67 -8.84 -0.48 1.4e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3126085 0.877 rs3120672 chr1:152255575 A/G cg03465714 chr1:152285911 FLG -0.45 -5.54 -0.32 7.12e-8 Atopic dermatitis; CESC cis rs2274273 0.870 rs7158768 chr14:55763612 A/C cg04306507 chr14:55594613 LGALS3 0.31 6.09 0.35 4.01e-9 Protein biomarker; CESC cis rs4474465 1.000 rs2373199 chr11:78142982 G/A cg27205649 chr11:78285834 NARS2 -0.42 -5.1 -0.3 6.41e-7 Alzheimer's disease (survival time); CESC cis rs447735 0.565 rs10852626 chr16:89914633 T/G cg04287289 chr16:89883240 FANCA 0.58 7.5 0.42 9.56e-13 Hemoglobin concentration; CESC trans rs9929218 0.861 rs3114409 chr16:68732049 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -10.29 -0.53 4.24e-21 Colorectal cancer; CESC cis rs6912958 0.702 rs6906769 chr6:88235949 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.08 -0.3 7.21e-7 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06467587 chr16:15808736 MYH11;NDE1 -0.56 -6.32 -0.36 1.13e-9 Gut microbiome composition (summer); CESC trans rs11098499 0.909 rs7659501 chr4:120371552 G/T cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs42648 0.935 rs42660 chr7:89982522 C/T cg23697855 chr7:89950296 NA 0.28 5.31 0.31 2.27e-7 Homocysteine levels; CESC cis rs4728302 0.583 rs12707091 chr7:133185749 A/G cg10665199 chr7:133106180 EXOC4 0.53 7.18 0.4 6.94e-12 Intelligence;Intelligence (multi-trait analysis); CESC cis rs2204008 0.702 rs3849999 chr12:38483498 G/A cg26384229 chr12:38710491 ALG10B -0.41 -5.41 -0.32 1.42e-7 Bladder cancer; CESC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg26335602 chr6:28129616 ZNF389 0.44 5.7 0.33 3.25e-8 Parkinson's disease; CESC cis rs2735413 0.918 rs12924772 chr16:78083115 T/C cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs6088590 1.000 rs6120747 chr20:33449769 T/C cg06115741 chr20:33292138 TP53INP2 0.63 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs3741151 1.000 rs75004180 chr11:73024739 A/G cg17517138 chr11:73019481 ARHGEF17 1.12 7.86 0.43 9.43e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs11098499 0.821 rs10032151 chr4:120391628 C/T cg24375607 chr4:120327624 NA 0.45 5.59 0.32 5.56e-8 Corneal astigmatism; CESC cis rs7927592 0.763 rs10896351 chr11:68386896 G/A cg01657329 chr11:68192670 LRP5 -0.47 -6.1 -0.35 3.69e-9 Total body bone mineral density; CESC cis rs13266463 0.830 rs6983790 chr8:143406575 A/G cg06454464 chr8:143427921 TSNARE1 0.41 5.41 0.32 1.41e-7 Schizophrenia; CESC cis rs7635838 0.718 rs2594981 chr3:11380638 C/G cg00170343 chr3:11313890 ATG7 0.56 8.19 0.45 1.15e-14 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00744550 chr2:242609941 ATG4B -0.53 -6.13 -0.35 3.12e-9 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs12137403 chr1:67437043 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.03 -14.53 -0.67 1.38e-35 Lymphocyte percentage of white cells; CESC cis rs854765 0.583 rs4341796 chr17:17839024 C/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.51 6.57 0.37 2.65e-10 Total body bone mineral density; CESC cis rs9911578 0.835 rs2301867 chr17:56480074 T/A cg12560992 chr17:57184187 TRIM37 -0.87 -14.52 -0.67 1.57e-35 Intelligence (multi-trait analysis); CESC cis rs2486288 0.656 rs8024620 chr15:45574329 C/T cg09092052 chr15:45571596 NA 0.44 5.26 0.31 2.98e-7 Glomerular filtration rate; CESC cis rs12545109 0.613 rs10958480 chr8:57278717 A/T cg09654669 chr8:57350985 NA -0.46 -5.82 -0.34 1.66e-8 Obesity-related traits; CESC cis rs10911251 0.546 rs12034436 chr1:183114797 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 13.23 0.63 5.03e-31 Colorectal cancer; CESC cis rs3733585 0.563 rs881971 chr4:9930962 A/G cg02734326 chr4:10020555 SLC2A9 -0.4 -5.76 -0.33 2.36e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11122272 0.735 rs2486743 chr1:231506928 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.03 -0.4 1.77e-11 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14528254 chr7:5862839 ZNF815 0.6 6.97 0.39 2.47e-11 Gut microbiome composition (summer); CESC cis rs7827545 1.000 rs2119879 chr8:135549042 T/C cg17885191 chr8:135476712 NA 0.49 6.87 0.39 4.45e-11 Hypertension (SNP x SNP interaction); CESC cis rs11231420 1 rs11231420 chr11:55644734 T/C cg09684106 chr11:55640291 NA -0.31 -5.2 -0.3 3.96e-7 Pelvic organ prolapse (moderate/severe); CESC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg08859206 chr1:53392774 SCP2 0.56 7.29 0.41 3.54e-12 Monocyte count; CESC cis rs9911578 0.835 rs9788975 chr17:56460800 G/A cg25039879 chr17:56429692 SUPT4H1 -0.39 -5.23 -0.31 3.39e-7 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14888445 chr13:101184494 A2LD1 0.49 6.59 0.38 2.34e-10 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00872270 chr16:3190814 ZNF213 0.45 6.3 0.36 1.23e-9 Fibrinogen levels; CESC cis rs2777491 0.574 rs1757468 chr15:41743574 T/A cg18705301 chr15:41695430 NDUFAF1 -1.06 -16.93 -0.72 4.47e-44 Ulcerative colitis; CESC cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg22834771 chr12:69754056 YEATS4 -0.48 -6.46 -0.37 4.96e-10 Blood protein levels; CESC cis rs6540556 0.769 rs9430017 chr1:209925058 C/T cg05527609 chr1:210001259 C1orf107 -0.66 -7.66 -0.43 3.56e-13 Red blood cell count; CESC cis rs1355223 0.583 rs1396881 chr11:34870506 G/T cg11058730 chr11:34937778 PDHX;APIP 0.82 12.62 0.61 6.79e-29 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs73206853 0.764 rs7314552 chr12:110618890 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.62 0.33 4.79e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2463822 1.000 rs115395195 chr11:62100353 G/A cg06239285 chr11:62104954 ASRGL1 -1.1 -9.26 -0.49 7.36e-18 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs3733585 0.699 rs62294332 chr4:9959989 T/C cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 6.05 0.35 4.83e-9 Tonsillectomy; CESC cis rs4604732 0.631 rs10925044 chr1:247627071 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.43 5.38 0.31 1.66e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs698813 0.614 rs811494 chr2:44725047 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.23 0.31 3.42e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs4253311 0.593 rs1511802 chr4:187150806 T/C cg24794857 chr4:187113578 CYP4V2 0.44 5.53 0.32 7.52e-8 Plasma renin activity levels;Circulating chromogranin peptide levels;Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06096824 chr1:51443952 NA 0.62 6.69 0.38 1.34e-10 Gut microbiome composition (summer); CESC cis rs3768617 1.000 rs3820697 chr1:183100226 T/C ch.1.3577855R chr1:183094577 LAMC1 0.65 9.05 0.49 3.07e-17 Fuchs's corneal dystrophy; CESC cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg22875332 chr1:76189707 ACADM 0.66 7.81 0.43 1.31e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs561341 0.660 rs7406043 chr17:30220152 C/G cg19193384 chr17:30244184 NA -0.55 -5.82 -0.34 1.65e-8 Hip circumference adjusted for BMI; CESC cis rs838147 0.534 rs2638280 chr19:49209318 G/A cg21064579 chr19:49206444 FUT2 0.5 6.82 0.39 6e-11 Dietary macronutrient intake; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27466766 chr8:144679319 EEF1D;TIGD5 -0.49 -6.81 -0.39 6.61e-11 Fibrinogen levels; CESC cis rs17490626 0.568 rs12413529 chr10:71211644 G/T cg12610070 chr10:71211762 TSPAN15 -0.32 -6.91 -0.39 3.55e-11 Thrombosis; CESC cis rs9399135 0.967 rs4896119 chr6:135293391 C/T cg22676075 chr6:135203613 NA 0.52 7.12 0.4 9.93e-12 Red blood cell count; CESC cis rs710216 0.957 rs12041787 chr1:43432275 G/C cg07803811 chr1:43423981 SLC2A1 0.47 5.05 0.3 8.26e-7 Red cell distribution width; CESC trans rs1003719 0.715 rs762139 chr21:38568475 A/T cg05290708 chr7:140372864 ADCK2 -0.45 -6.1 -0.35 3.76e-9 Eye color traits; CESC cis rs7659604 0.628 rs3828485 chr4:122722368 G/A cg19748678 chr4:122722346 EXOSC9 0.76 9.57 0.51 7.95e-19 Type 2 diabetes; CESC cis rs950027 0.549 rs12909409 chr15:45608582 T/G cg21132104 chr15:45694354 SPATA5L1 -0.59 -7.2 -0.4 6.4e-12 Response to fenofibrate (adiponectin levels); CESC cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg00255919 chr5:131827918 IRF1 0.51 8.68 0.47 4.19e-16 Asthma (sex interaction); CESC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs2777491 0.957 rs8026197 chr15:41711447 C/T cg20272979 chr15:41787780 ITPKA 0.45 6.69 0.38 1.3100000000000001e-10 Ulcerative colitis; CESC trans rs1945213 0.694 rs1384088 chr11:55848713 G/C cg15704280 chr7:45808275 SEPT13 -0.76 -7.3 -0.41 3.45e-12 Acute lymphoblastic leukemia (childhood); CESC trans rs1368304 0.850 rs17107992 chr5:147617065 A/C cg06836181 chr2:64995545 NA -0.63 -6.05 -0.35 4.84e-9 IgG glycosylation; CESC cis rs17270561 0.609 rs7754296 chr6:25744878 A/G cg17691542 chr6:26056736 HIST1H1C 0.4 5.22 0.31 3.55e-7 Iron status biomarkers; CESC cis rs2204008 0.703 rs12818324 chr12:38213871 G/A cg26384229 chr12:38710491 ALG10B -0.41 -5.5 -0.32 9.03e-8 Bladder cancer; CESC cis rs4969178 0.965 rs4969179 chr17:76391454 A/C cg05887092 chr17:76393375 PGS1 0.58 9.11 0.49 2.01e-17 HDL cholesterol levels; CESC cis rs2180341 0.920 rs1073931 chr6:127681762 A/T cg27446573 chr6:127587934 RNF146 1.06 15.88 0.7 2.39e-40 Breast cancer; CESC cis rs12971120 0.947 rs8084410 chr18:72168486 T/C cg25817165 chr18:72167213 CNDP2 -0.56 -7.84 -0.43 1.09e-13 Refractive error; CESC cis rs36051895 0.632 rs7036536 chr9:5181610 T/C cg02405213 chr9:5042618 JAK2 -0.52 -6.72 -0.38 1.11e-10 Pediatric autoimmune diseases; CESC cis rs6570726 0.935 rs379164 chr6:145829093 A/T cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs72781680 1.000 rs72796316 chr2:24132272 T/C cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -7.04 -0.4 1.69e-11 Extrinsic epigenetic age acceleration; CESC cis rs9457247 1.000 rs2149090 chr6:167372764 T/C cg25258033 chr6:167368657 RNASET2 -0.41 -6.2 -0.36 2.17e-9 Crohn's disease; CESC cis rs9611565 0.525 rs9611548 chr22:41704143 G/T cg03806693 chr22:41940476 POLR3H -0.84 -9.48 -0.5 1.53e-18 Vitiligo; CESC trans rs801193 0.935 rs3800820 chr7:66147178 C/T cg26939375 chr7:64535504 NA -0.63 -8.5 -0.46 1.4e-15 Aortic root size; CESC cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg10018233 chr7:150070692 REPIN1 0.45 6.88 0.39 4.2e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs28489187 0.643 rs1884139 chr1:85845998 G/T cg16011679 chr1:85725395 C1orf52 0.49 5.8 0.34 1.84e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs73001065 0.818 rs10500212 chr19:19723215 C/T cg03709012 chr19:19516395 GATAD2A 0.92 6.24 0.36 1.7e-9 LDL cholesterol; CESC cis rs1707322 1.000 rs9429186 chr1:46539687 C/T cg03146154 chr1:46216737 IPP -0.7 -9.2 -0.49 1.08e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs887829 0.569 rs3821242 chr2:234637803 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.54 -7.47 -0.42 1.2e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs2204008 0.774 rs11514062 chr12:38332297 A/C cg13010199 chr12:38710504 ALG10B 0.42 5.34 0.31 2.02e-7 Bladder cancer; CESC cis rs116095464 0.510 rs10057501 chr5:239545 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.21 0.3 3.76e-7 Breast cancer; CESC cis rs6991838 0.584 rs60023200 chr8:66486782 C/T cg13398993 chr8:66546079 ARMC1 -0.46 -5.54 -0.32 7.22e-8 Intelligence (multi-trait analysis); CESC cis rs6580649 1.000 rs10783227 chr12:48400617 C/T cg05342945 chr12:48394962 COL2A1 -0.56 -6.78 -0.38 7.56e-11 Lung cancer; CESC cis rs10479542 0.929 rs10078796 chr5:178978883 T/A cg19626725 chr5:178986131 RUFY1 0.39 6.35 0.36 9.27e-10 Lung cancer; CESC cis rs155076 1.000 rs261407 chr13:21855213 C/A cg11317459 chr13:21872234 NA -1.06 -11.89 -0.59 1.99e-26 White matter hyperintensity burden; CESC cis rs6430585 0.702 rs1042712 chr2:136545844 C/G cg07169764 chr2:136633963 MCM6 -1.19 -17.44 -0.73 7.09e-46 Corneal structure; CESC cis rs2228479 0.850 rs17233448 chr16:89816424 G/T cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg18225595 chr11:63971243 STIP1 0.74 10.31 0.53 3.67e-21 Platelet count; CESC trans rs10517270 0.744 rs10028228 chr4:33212652 A/G cg25767985 chr11:43965591 NA 0.62 6.12 0.35 3.28e-9 Alzheimer's disease (age of onset); CESC cis rs4243830 0.850 rs12563717 chr1:6599557 T/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.84 7.28 0.41 3.87e-12 Body mass index; CESC cis rs1018836 0.851 rs7014073 chr8:91618548 T/C cg16814680 chr8:91681699 NA -0.77 -11.99 -0.59 9.6e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs113835537 0.529 rs11227503 chr11:66275242 G/C cg22134325 chr11:66188745 NPAS4 0.36 5.66 0.33 3.82e-8 Airway imaging phenotypes; CESC cis rs897984 0.571 rs7184567 chr16:31021078 C/T cg02466173 chr16:30829666 NA -0.4 -6.71 -0.38 1.16e-10 Dementia with Lewy bodies; CESC cis rs7829975 0.511 rs1401390 chr8:8136410 C/T cg15556689 chr8:8085844 FLJ10661 0.54 6.32 0.36 1.13e-9 Mood instability; CESC cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg02297831 chr4:17616191 MED28 0.44 5.35 0.31 1.92e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8017423 0.935 rs11626869 chr14:90788985 A/G cg14092571 chr14:90743983 NA 0.55 8.47 0.46 1.76e-15 Mortality in heart failure; CESC cis rs616402 0.527 rs10779737 chr1:10580275 C/G cg07384165 chr1:10488281 NA -0.49 -7.21 -0.41 5.8e-12 Breast size; CESC cis rs6582630 0.555 rs1906260 chr12:38601013 T/G cg26384229 chr12:38710491 ALG10B 0.74 11.14 0.56 7.02e-24 Drug-induced liver injury (flucloxacillin); CESC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg14393609 chr7:65229607 NA 0.43 6.03 0.35 5.38e-9 Aortic root size; CESC cis rs10896135 0.526 rs1987169 chr11:66448044 A/G cg24851651 chr11:66362959 CCS -0.55 -7.27 -0.41 3.98e-12 Bipolar disorder; CESC cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4237845 0.537 rs10747786 chr12:58260601 G/T cg04478727 chr12:58166393 METTL1;FAM119B 0.48 5.37 0.31 1.7e-7 Intelligence (multi-trait analysis); CESC cis rs62158211 0.565 rs57611236 chr2:114103804 A/T cg17784749 chr2:114082611 LOC440839 0.51 6.34 0.36 1e-9 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CESC cis rs9584850 0.562 rs17471066 chr13:99164699 A/G cg20750642 chr13:99100586 FARP1 -0.4 -5.55 -0.32 6.99e-8 Neuroticism; CESC cis rs2108622 0.711 rs12609820 chr19:15978057 T/C cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24954670 chr3:50337092 HYAL3;NAT6 0.55 6.38 0.36 7.84e-10 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg14440974 chr22:39074834 NA 0.38 5.15 0.3 5.06e-7 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23676784 chr1:22968681 C1QC 0.59 6.78 0.38 7.79e-11 Gut microbiome composition (summer); CESC cis rs2979489 0.580 rs73245347 chr8:30448213 T/G cg26383811 chr8:30366931 RBPMS -0.66 -7.8 -0.43 1.4e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs7219021 0.705 rs11079842 chr17:47002762 G/A cg16584676 chr17:46985605 UBE2Z -0.62 -7.22 -0.41 5.5e-12 Schizophrenia or bipolar disorder; CESC trans rs7837860 0.588 rs16880580 chr8:89287763 A/G cg04391754 chr17:18022714 MYO15A 0.52 6.12 0.35 3.35e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9715521 0.775 rs67846233 chr4:59848576 G/A cg11281224 chr4:60001000 NA -0.5 -6.52 -0.37 3.51e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25184507 chr17:7760147 CYB5D1;LSMD1 0.51 6.52 0.37 3.55e-10 Gut microbiota (bacterial taxa); CESC trans rs116095464 0.558 rs10057626 chr5:239720 T/G cg00938859 chr5:1591904 SDHAP3 0.64 6.99 0.39 2.27e-11 Breast cancer; CESC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs13631 0.965 rs9411307 chr9:139994947 C/T cg14289826 chr9:140003911 NA 0.34 6.44 0.37 5.61e-10 Cerebrospinal fluid biomarker levels; CESC cis rs12618769 0.652 rs1062847 chr2:99226173 T/A cg10123293 chr2:99228465 UNC50 0.4 5.31 0.31 2.33e-7 Bipolar disorder; CESC cis rs6831352 0.760 rs1311616 chr4:100012303 T/G cg13256891 chr4:100009986 ADH5 0.74 7.97 0.44 4.75e-14 Alcohol dependence; CESC cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 11.39 0.57 1.01e-24 Hip circumference adjusted for BMI; CESC cis rs6500395 0.962 rs9937134 chr16:48577683 T/A cg04672837 chr16:48644449 N4BP1 0.45 5.43 0.32 1.3e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs8067354 0.831 rs2333617 chr17:57896220 T/A cg02344993 chr17:57696989 CLTC -0.48 -6.15 -0.35 2.86e-9 Hemoglobin concentration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17484976 chr20:60982411 CABLES2 0.44 6.2 0.36 2.19e-9 Gut microbiota (bacterial taxa); CESC cis rs6430585 0.527 rs1900306 chr2:136416533 G/A cg07169764 chr2:136633963 MCM6 1.14 12.87 0.62 9.12e-30 Corneal structure; CESC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.02 0.52 2.97e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs748404 0.660 rs690446 chr15:43761264 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.5 0.42 9.94e-13 Lung cancer; CESC cis rs2243480 0.908 rs55876148 chr7:65379800 G/A cg18252515 chr7:66147081 NA -1.18 -10.88 -0.56 5.02e-23 Diabetic kidney disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20723414 chr7:157207071 DNAJB6 0.48 6.27 0.36 1.46e-9 Fibrinogen levels; CESC cis rs4604732 0.536 rs78019731 chr1:247626430 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg08132940 chr7:1081526 C7orf50 -0.49 -5.04 -0.3 8.63e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6598955 0.670 rs7520517 chr1:26556385 A/C cg19743891 chr1:26644573 UBXN11;CD52 -0.27 -5.16 -0.3 4.86e-7 Obesity-related traits; CESC cis rs7208859 0.623 rs12103440 chr17:29086657 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6866344 0.697 rs11742808 chr5:178131658 G/A cg10224037 chr5:178157518 ZNF354A 0.67 7.35 0.41 2.46e-12 Neutrophil percentage of white cells; CESC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg03806693 chr22:41940476 POLR3H 1.14 13.61 0.64 2.45e-32 Vitiligo; CESC cis rs11690935 0.788 rs6715929 chr2:172877507 A/G cg13550731 chr2:172543902 DYNC1I2 -0.62 -8.82 -0.48 1.55e-16 Schizophrenia; CESC cis rs2806561 0.765 rs652783 chr1:23514313 G/T cg12483005 chr1:23474871 LUZP1 0.38 6.0 0.35 6.44e-9 Height; CESC cis rs6546550 0.743 rs6546548 chr2:70017022 A/G cg02498382 chr2:70120550 SNRNP27 -0.29 -5.07 -0.3 7.61e-7 Prevalent atrial fibrillation; CESC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg15369054 chr17:80825471 TBCD -0.51 -7.22 -0.41 5.36e-12 Breast cancer; CESC cis rs7809950 0.731 rs2712196 chr7:107128797 G/T cg23024343 chr7:107201750 COG5 -0.57 -7.42 -0.41 1.55e-12 Coronary artery disease; CESC cis rs36715 0.904 rs36701 chr5:127552529 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 7.55 0.42 7.15e-13 Breast cancer; CESC cis rs8180040 0.739 rs11719306 chr3:47184182 G/A cg27129171 chr3:47204927 SETD2 0.7 10.87 0.56 5.19e-23 Colorectal cancer; CESC cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg11366901 chr6:160182831 ACAT2 0.84 11.06 0.56 1.28e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs9430161 0.564 rs12081176 chr1:11034145 T/C cg27631724 chr1:11040367 C1orf127 0.38 6.21 0.36 2.02e-9 Ewing sarcoma; CESC cis rs453301 0.571 rs2929452 chr8:9084465 G/A cg15556689 chr8:8085844 FLJ10661 -0.51 -6.39 -0.37 7.51e-10 Joint mobility (Beighton score); CESC cis rs6460942 0.597 rs62449509 chr7:12515013 C/T cg20607287 chr7:12443886 VWDE -0.7 -7.61 -0.42 4.88e-13 Coronary artery disease; CESC cis rs1670533 0.746 rs688008 chr4:1082829 T/C cg27284194 chr4:1044797 NA 0.48 6.07 0.35 4.52e-9 Recombination rate (females); CESC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg06219351 chr7:158114137 PTPRN2 -0.5 -7.84 -0.43 1.1e-13 Calcium levels; CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.47 0.37 4.7e-10 Electroencephalogram traits; CESC cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.03e-7 Colorectal cancer; CESC cis rs57221529 0.766 rs12521988 chr5:556421 C/T cg09021430 chr5:549028 NA -0.42 -5.26 -0.31 2.92e-7 Lung disease severity in cystic fibrosis; CESC cis rs16854884 0.657 rs10513235 chr3:143698664 T/C cg06585982 chr3:143692056 C3orf58 0.45 5.62 0.33 4.88e-8 Economic and political preferences (feminism/equality); CESC cis rs2070997 0.607 rs10901284 chr9:133668799 T/C cg11464064 chr9:133710261 ABL1 0.55 6.28 0.36 1.38e-9 Response to amphetamines; CESC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg21782813 chr7:2030301 MAD1L1 -0.39 -5.48 -0.32 9.92e-8 Bipolar disorder and schizophrenia; CESC cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg22875332 chr1:76189707 ACADM 0.64 6.42 0.37 6.23e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11150038 0.826 rs7203483 chr16:78085836 C/T cg04733911 chr16:78082701 NA 0.42 5.24 0.31 3.21e-7 Colorectal or endometrial cancer; CESC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.44 0.5 1.97e-18 Menopause (age at onset); CESC cis rs2880765 0.835 rs4536419 chr15:86039471 C/T cg19183879 chr15:85880815 NA -0.26 -5.36 -0.31 1.78e-7 Coronary artery disease; CESC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg02931644 chr1:25747376 RHCE -0.4 -6.7 -0.38 1.27e-10 Erythrocyte sedimentation rate; CESC cis rs863345 0.604 rs11265015 chr1:158503252 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.89 -0.39 4.12e-11 Pneumococcal bacteremia; CESC cis rs55882075 0.634 rs12518476 chr5:179110850 A/G cg14593053 chr5:179126677 CANX 0.52 6.68 0.38 1.38e-10 Monocyte percentage of white cells; CESC cis rs4919044 0.808 rs2486687 chr10:94778283 T/C cg00487187 chr10:94451625 HHEX -0.45 -5.05 -0.3 8.21e-7 Coronary artery disease; CESC cis rs561341 1.000 rs537166 chr17:30326827 C/T cg19193384 chr17:30244184 NA -0.61 -6.39 -0.37 7.37e-10 Hip circumference adjusted for BMI; CESC cis rs965469 0.779 rs6051830 chr20:3373397 T/C cg25506879 chr20:3388711 C20orf194 -0.49 -5.28 -0.31 2.63e-7 IFN-related cytopenia; CESC cis rs1707322 0.656 rs3014210 chr1:46066608 A/G cg05343316 chr1:45956843 TESK2 -0.54 -6.69 -0.38 1.32e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06434972 chr7:44122219 POLM -0.45 -6.56 -0.37 2.78e-10 Gambling; CESC trans rs2727020 0.576 rs12293522 chr11:49558425 T/A cg03929089 chr4:120376271 NA -0.85 -13.62 -0.64 2.22e-32 Coronary artery disease; CESC cis rs593982 0.920 rs563427 chr11:65484569 A/G cg08755490 chr11:65554678 OVOL1 1.17 10.68 0.55 2.27e-22 Atopic dermatitis; CESC cis rs9929218 0.954 rs4420522 chr16:68822971 A/G cg02972257 chr16:68554789 NA 0.45 5.39 0.31 1.58e-7 Colorectal cancer; CESC cis rs72627509 0.904 rs781663 chr4:57781754 A/G cg26694713 chr4:57773883 REST 0.57 5.56 0.32 6.47e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg00129232 chr17:37814104 STARD3 -0.57 -7.72 -0.43 2.35e-13 Glomerular filtration rate (creatinine); CESC cis rs7662987 0.517 rs2851286 chr4:100014976 A/G cg13256891 chr4:100009986 ADH5 -0.82 -8.61 -0.47 6.51e-16 Smoking initiation; CESC cis rs7772486 0.686 rs857877 chr6:145976230 A/C cg23711669 chr6:146136114 FBXO30 -0.98 -15.19 -0.68 6.34e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs863345 0.564 rs12145401 chr1:158494693 A/G cg12129480 chr1:158549410 OR10X1 -0.34 -7.02 -0.4 1.84e-11 Pneumococcal bacteremia; CESC cis rs7568458 0.684 rs3731828 chr2:85806266 C/T cg02493740 chr2:85810744 VAMP5 -0.56 -8.31 -0.45 4.99e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs5753618 0.583 rs5753612 chr22:31821479 T/C cg00478049 chr22:31556069 RNF185 -0.43 -5.11 -0.3 6.22e-7 Colorectal cancer; CESC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg18904891 chr8:8559673 CLDN23 0.67 7.49 0.42 1.01e-12 Obesity-related traits; CESC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg06456125 chr7:65229604 NA 0.41 5.37 0.31 1.76e-7 Aortic root size; CESC cis rs7312933 0.558 rs11181501 chr12:42822671 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.45 0.37 5.25e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg04025307 chr7:1156635 C7orf50 0.42 5.28 0.31 2.76e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7809799 1.000 rs6465739 chr7:98764248 A/C cg05967295 chr7:98741636 SMURF1 -0.75 -5.29 -0.31 2.56e-7 Ulcerative colitis; CESC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg21144161 chr5:423903 AHRR 0.37 5.98 0.34 7.12e-9 Cystic fibrosis severity; CESC cis rs11249608 0.548 rs17078988 chr5:178459283 A/G cg21905437 chr5:178450457 ZNF879 0.58 8.06 0.44 2.69e-14 Pubertal anthropometrics; CESC cis rs8177179 0.967 rs4287912 chr3:133437778 A/G cg17775713 chr3:133465469 TF 0.31 5.59 0.32 5.77e-8 Iron status biomarkers (transferrin levels); CESC cis rs9467711 0.606 rs71557334 chr6:26365913 G/T cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.59e-7 Autism spectrum disorder or schizophrenia; CESC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 12.74 0.62 2.53e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs870825 0.616 rs28666955 chr4:185631338 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.0 0.4 2.05e-11 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16063617 chr5:128430663 ISOC1 -0.52 -6.96 -0.39 2.62e-11 Fibrinogen levels; CESC trans rs10518765 0.786 rs17818441 chr15:54638829 A/G cg09098624 chr8:11558334 NA 0.56 6.05 0.35 4.98e-9 Select biomarker traits; CESC cis rs4674676 1 rs4674676 chr2:223529112 A/G cg25565276 chr2:223520875 FARSB 1.06 14.94 0.68 4.85e-37 Chin dimples; CESC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg24060327 chr5:131705240 SLC22A5 -0.62 -8.03 -0.44 3.17e-14 Blood metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01623343 chr16:354374 AXIN1 0.49 6.84 0.39 5.42e-11 Fibrinogen levels; CESC cis rs4979906 1.000 rs4979786 chr10:79444965 T/C cg00983440 chr10:79422392 NA -0.48 -5.12 -0.3 5.83e-7 Mortality in heart failure; CESC cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg02773041 chr1:40204384 PPIE 0.51 7.24 0.41 4.72e-12 Blood protein levels; CESC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg13206674 chr6:150067644 NUP43 0.43 5.94 0.34 8.74e-9 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14831746 chr12:49961631 MCRS1 -0.57 -6.66 -0.38 1.61e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg25036284 chr2:26402008 FAM59B -0.58 -6.57 -0.37 2.69e-10 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg19077165 chr18:44547161 KATNAL2 -0.53 -7.82 -0.43 1.22e-13 Personality dimensions; CESC cis rs72634258 0.838 rs10489450 chr1:8079301 C/T cg00042356 chr1:8021962 PARK7 0.82 7.53 0.42 7.8e-13 Inflammatory bowel disease; CESC cis rs9486719 0.895 rs12190520 chr6:96928620 A/C cg18709589 chr6:96969512 KIAA0776 -0.54 -5.97 -0.34 7.42e-9 Migraine;Coronary artery disease; CESC cis rs4780401 0.728 rs8191335 chr16:11771353 C/A cg01061890 chr16:11836724 TXNDC11 -0.49 -6.63 -0.38 1.88e-10 Rheumatoid arthritis; CESC trans rs7726839 0.526 rs11960158 chr5:568665 C/T cg25482853 chr8:67687455 SGK3 0.97 10.85 0.55 6.23e-23 Obesity-related traits; CESC cis rs2286503 0.901 rs2286505 chr7:22854840 G/A cg13679077 chr7:22862647 TOMM7 0.41 5.21 0.3 3.75e-7 Fibrinogen; CESC trans rs5769765 0.773 rs9616206 chr22:50310847 G/T cg09872104 chr7:134855509 C7orf49 -0.57 -6.47 -0.37 4.78e-10 Schizophrenia; CESC cis rs733175 0.951 rs6826764 chr4:10030794 C/G cg00071950 chr4:10020882 SLC2A9 -0.47 -5.38 -0.31 1.6e-7 Psychosis and Alzheimer's disease; CESC cis rs6460942 0.915 rs10488158 chr7:12508894 C/T cg20607287 chr7:12443886 VWDE -0.76 -8.53 -0.46 1.16e-15 Coronary artery disease; CESC cis rs9438901 0.592 rs1293259 chr1:25695835 G/A cg12421513 chr1:25599066 RHD -0.43 -5.16 -0.3 4.94e-7 Red cell distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02846228 chr16:31102495 VKORC1 -0.54 -6.38 -0.36 8.05e-10 Gut microbiome composition (summer); CESC cis rs3820068 0.603 rs10492986 chr1:15988702 T/C cg16988262 chr1:15930761 NA 0.35 5.67 0.33 3.64e-8 Systolic blood pressure; CESC cis rs10882165 0.547 rs4918904 chr10:94961320 A/T cg00992348 chr10:94926053 NA 0.31 5.48 0.32 9.91e-8 Refractive error; CESC cis rs4253772 0.591 rs113101219 chr22:46659186 C/A cg00784671 chr22:46762841 CELSR1 -0.51 -5.48 -0.32 9.94e-8 LDL cholesterol;Cholesterol, total; CESC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg24675658 chr1:53192096 ZYG11B 0.53 6.69 0.38 1.29e-10 Monocyte count; CESC cis rs11853189 0.873 rs117636273 chr15:78556895 G/A cg22935921 chr15:78556834 DNAJA4 0.61 5.1 0.3 6.35e-7 Red cell distribution width; CESC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg06873352 chr17:61820015 STRADA 0.47 6.92 0.39 3.31e-11 Height; CESC cis rs921968 0.565 rs3731876 chr2:219602819 G/A cg02176678 chr2:219576539 TTLL4 -0.45 -7.81 -0.43 1.36e-13 Mean corpuscular hemoglobin concentration; CESC cis rs2346177 0.542 rs13020043 chr2:46698431 A/T cg02822958 chr2:46747628 ATP6V1E2 0.45 5.59 0.32 5.67e-8 HDL cholesterol; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06995880 chr1:61516444 NA -0.44 -6.28 -0.36 1.4e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs710216 0.843 rs710220 chr1:43415346 G/T cg03128534 chr1:43423976 SLC2A1 0.59 7.25 0.41 4.55e-12 Red cell distribution width; CESC cis rs62158211 1.000 rs62158211 chr2:114106139 G/T cg17784749 chr2:114082611 LOC440839 0.72 7.71 0.43 2.57e-13 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CESC cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg03538708 chr1:25844672 NA -0.41 -6.29 -0.36 1.29e-9 Plateletcrit;Mean corpuscular volume; CESC cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs4588572 0.581 rs4235706 chr5:77644512 G/A cg11547950 chr5:77652471 NA 0.45 6.03 0.35 5.49e-9 Triglycerides; CESC cis rs6487679 0.526 rs7305336 chr12:9375089 C/A cg08997352 chr12:9597637 DDX12 -0.51 -5.62 -0.33 4.77e-8 Non-alcoholic fatty liver disease histology (AST); CESC cis rs2832077 0.527 rs2250141 chr21:30241984 A/T cg03476357 chr21:30257390 N6AMT1 0.46 5.79 0.34 1.94e-8 Cognitive test performance; CESC cis rs9487051 0.676 rs1608041 chr6:109595903 G/A cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10500953 chr16:346518 AXIN1 0.46 6.37 0.36 8.29e-10 Fibrinogen levels; CESC trans rs802075 0.905 rs2396917 chr6:49635987 G/A cg06254729 chr2:28550422 BRE -0.36 -6.13 -0.35 3.15e-9 Bone mineral density (hip) and age at menarche; CESC cis rs7786877 0.626 rs11770389 chr7:100221218 T/G cg27028030 chr7:100209634 MOSPD3 0.59 5.65 0.33 4.13e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2929278 0.736 rs2412823 chr15:44227270 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.39 -5.07 -0.3 7.58e-7 Schizophrenia; CESC cis rs3733585 0.673 rs6849729 chr4:9958732 T/C cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7116495 1.000 rs560777 chr11:71770602 C/T cg10381502 chr11:71823885 C11orf51 0.67 5.73 0.33 2.79e-8 Severe influenza A (H1N1) infection; CESC cis rs8018808 0.935 rs11159261 chr14:77921120 A/G cg20045696 chr14:77926864 AHSA1 0.47 6.59 0.38 2.35e-10 Myeloid white cell count; CESC cis rs1538970 0.781 rs10890330 chr1:45920406 G/A cg06784218 chr1:46089804 CCDC17 0.35 5.52 0.32 8.19e-8 Platelet count; CESC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.62 6.4 0.37 7.19e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28374715 0.532 rs3204853 chr15:41689166 C/A cg18705301 chr15:41695430 NDUFAF1 -1.07 -17.69 -0.74 8.95e-47 Ulcerative colitis; CESC cis rs2249625 0.508 rs114505309 chr6:72892383 G/A cg18830697 chr6:72922368 RIMS1 0.42 5.99 0.35 6.73e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs4835473 0.932 rs1450236 chr4:144704222 G/A cg25736465 chr4:144833511 NA -0.33 -5.36 -0.31 1.81e-7 Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19769989 chr1:43353266 NA -0.52 -6.03 -0.35 5.34e-9 Gut microbiome composition (summer); CESC trans rs7819412 0.740 rs11250119 chr8:11037034 C/T cg06636001 chr8:8085503 FLJ10661 -0.6 -8.14 -0.45 1.53e-14 Triglycerides; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00187635 chr16:83986795 OSGIN1 0.39 6.04 0.35 5.13e-9 Gambling; CESC cis rs7824557 0.564 rs2572379 chr8:11237480 A/G cg21775007 chr8:11205619 TDH -0.54 -7.98 -0.44 4.52e-14 Retinal vascular caliber; CESC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg11764359 chr7:65958608 NA 0.7 9.9 0.52 7.02e-20 Aortic root size; CESC cis rs1843834 0.574 rs6436499 chr2:225456551 A/T cg12698349 chr2:225449008 CUL3 0.55 7.89 0.44 7.83e-14 IgE levels in asthmatics (D.p. specific); CESC cis rs12477438 0.798 rs7570657 chr2:99654281 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -8.45 -0.46 2.02e-15 Chronic sinus infection; CESC cis rs7267979 0.966 rs2257233 chr20:25265984 A/C cg08601574 chr20:25228251 PYGB -0.39 -5.59 -0.33 5.51e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs3105593 1.000 rs7167138 chr15:50958998 C/G cg08437265 chr15:50716283 USP8 0.46 6.07 0.35 4.49e-9 QT interval; CESC cis rs804280 0.525 rs1004712 chr8:11622293 C/T cg12395012 chr8:11607386 GATA4 -0.37 -5.48 -0.32 9.78e-8 Myopia (pathological); CESC cis rs26868 0.690 rs26835 chr16:2237549 C/T cg07587117 chr16:2239488 CASKIN1 0.51 9.28 0.5 6.12e-18 Height; CESC cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg24110177 chr3:50126178 RBM5 0.53 7.25 0.41 4.51e-12 Intelligence (multi-trait analysis); CESC cis rs6120849 0.754 rs3746446 chr20:33574765 T/C cg24642439 chr20:33292090 TP53INP2 0.68 6.74 0.38 9.91e-11 Protein C levels; CESC cis rs3733585 0.699 rs6834893 chr4:9959123 C/T cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03865041 chr16:71842666 AP1G1 -0.47 -6.5 -0.37 4.05e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs16858210 0.874 rs1879256 chr3:183609061 A/G cg25686905 chr3:183603175 PARL -0.33 -5.99 -0.35 6.69e-9 Menopause (age at onset); CESC cis rs6963495 0.818 rs73190161 chr7:105156871 C/T cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs12995491 0.902 rs6737641 chr2:88529471 A/T cg07952391 chr2:88470173 THNSL2 -0.55 -8.33 -0.46 4.44e-15 Response to metformin (IC50); CESC trans rs561341 0.714 rs55925849 chr17:30253085 C/T cg20587970 chr11:113659929 NA -1.43 -17.6 -0.73 1.89e-46 Hip circumference adjusted for BMI; CESC cis rs265548 0.608 rs36690 chr19:17910483 C/T cg04517722 chr19:17905589 B3GNT3 0.43 5.61 0.33 5.12e-8 Tumor biomarkers; CESC cis rs61931739 0.782 rs451940 chr12:34196005 T/C cg19457237 chr12:34500585 NA -0.38 -5.37 -0.31 1.69e-7 Morning vs. evening chronotype; CESC cis rs918629 0.798 rs7705279 chr5:95324375 C/T cg16656078 chr5:95278638 ELL2 -0.38 -5.52 -0.32 8.22e-8 IgG glycosylation; CESC cis rs6690583 0.623 rs898036 chr1:85521904 A/T cg11262906 chr1:85462892 MCOLN2 0.54 5.06 0.3 7.79e-7 Serum sulfate level; CESC cis rs854765 0.647 rs6502637 chr17:17986098 A/G cg16928487 chr17:17741425 SREBF1 -0.53 -8.64 -0.47 5.33e-16 Total body bone mineral density; CESC cis rs6032067 0.852 rs2233882 chr20:43835683 T/A cg11264863 chr20:43835661 SEMG1 0.48 5.26 0.31 2.99e-7 Blood protein levels; CESC cis rs67478160 0.643 rs4900594 chr14:104251006 C/T cg08213375 chr14:104286397 PPP1R13B 0.55 10.97 0.56 2.52e-23 Schizophrenia; CESC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg11742103 chr11:62369870 EML3;MTA2 0.56 8.11 0.45 1.94e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg18876405 chr7:65276391 NA -0.53 -7.18 -0.4 7e-12 Aortic root size; CESC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg13770153 chr20:60521292 NA -0.44 -5.7 -0.33 3.2e-8 Body mass index; CESC cis rs12540874 0.522 rs4947641 chr7:50489038 C/T cg18232548 chr7:50535776 DDC -0.46 -6.67 -0.38 1.49e-10 Systemic sclerosis; CESC cis rs8064299 0.967 rs878905 chr17:72769411 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.63 8.98 0.48 5.27e-17 Monocyte count; CESC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.95 10.25 0.53 5.58e-21 Platelet count; CESC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg26343298 chr8:95960752 TP53INP1 0.37 6.22 0.36 1.96e-9 Type 2 diabetes; CESC cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg09035930 chr12:129282057 SLC15A4 0.69 9.2 0.49 1.1e-17 Systemic lupus erythematosus; CESC cis rs7927771 0.524 rs7932703 chr11:47769936 A/C cg18512352 chr11:47633146 NA 0.34 5.24 0.31 3.22e-7 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21394442 chr8:110346440 ENY2;NUDCD1 -0.59 -6.97 -0.39 2.49e-11 Gut microbiome composition (summer); CESC cis rs1003719 0.667 rs73201942 chr21:38475164 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 6.62 0.38 1.99e-10 Eye color traits; CESC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg04317338 chr11:64019027 PLCB3 0.49 5.9 0.34 1.11e-8 Platelet count; CESC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.71 0.38 1.2e-10 Prudent dietary pattern; CESC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.71 -0.33 2.98e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg04369109 chr6:150039330 LATS1 -0.43 -5.89 -0.34 1.19e-8 Lung cancer; CESC cis rs36051895 0.695 rs7851556 chr9:5022807 C/T cg02405213 chr9:5042618 JAK2 -0.46 -5.52 -0.32 7.88e-8 Pediatric autoimmune diseases; CESC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.09 0.3 6.84e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8060686 0.516 rs9939821 chr16:68167787 T/A cg26727032 chr16:67993705 SLC12A4 -0.55 -7.65 -0.43 3.84e-13 HDL cholesterol;Metabolic syndrome; CESC cis rs2191566 0.576 rs381759 chr19:44495145 A/G cg20607764 chr19:44506953 ZNF230 -0.43 -5.36 -0.31 1.78e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.96e-10 Bipolar disorder; CESC cis rs55794721 0.509 rs12027135 chr1:25775733 A/T cg03538708 chr1:25844672 NA -0.4 -5.96 -0.34 7.96e-9 Plateletcrit;Mean corpuscular volume; CESC cis rs8071756 1.000 rs11078563 chr17:1576369 A/G ch.17.72133F chr17:1577994 PRPF8 -0.49 -5.15 -0.3 5.09e-7 Blood protein levels; CESC cis rs425277 0.917 rs262656 chr1:2088754 A/C cg16545954 chr1:2118288 C1orf86 0.33 5.47 0.32 1.02e-7 Height; CESC cis rs67478160 0.619 rs10083367 chr14:104314183 C/G cg08213375 chr14:104286397 PPP1R13B -0.54 -10.67 -0.55 2.33e-22 Schizophrenia; CESC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg26839252 chr6:160211577 TCP1;MRPL18 0.47 5.86 0.34 1.38e-8 Age-related macular degeneration (geographic atrophy); CESC cis rs752010 0.714 rs2182606 chr1:42082375 T/C cg12614395 chr1:42085415 HIVEP3 0.3 5.26 0.31 3.01e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs3820068 0.677 rs72643691 chr1:15856251 T/C cg17385448 chr1:15911702 AGMAT 0.36 5.75 0.33 2.43e-8 Systolic blood pressure; CESC cis rs3740540 0.530 rs2362507 chr10:126290820 A/G cg04949429 chr10:126290192 LHPP 0.4 5.61 0.33 5.19e-8 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs17376456 0.757 rs1031424 chr5:93139706 G/C cg25358565 chr5:93447407 FAM172A 1.11 10.66 0.55 2.6e-22 Diabetic retinopathy; CESC cis rs4253772 0.591 rs6008546 chr22:46686377 T/G cg18190219 chr22:46762943 CELSR1 -0.46 -5.16 -0.3 4.87e-7 LDL cholesterol;Cholesterol, total; CESC cis rs10465746 0.682 rs882897 chr1:84426049 A/T cg10977910 chr1:84465055 TTLL7 0.51 6.99 0.39 2.23e-11 Obesity-related traits; CESC cis rs2070488 0.965 rs13097628 chr3:38521156 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.92 16.74 0.72 2.01e-43 Electrocardiographic conduction measures; CESC cis rs17095355 1.000 rs4565840 chr10:111717140 A/G cg00817464 chr10:111662876 XPNPEP1 -0.44 -5.28 -0.31 2.72e-7 Biliary atresia; CESC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.59 -7.65 -0.43 3.69e-13 Total body bone mineral density; CESC cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg03676636 chr4:99064102 C4orf37 0.36 5.36 0.31 1.78e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 1.000 rs4815418 chr20:25382211 T/G cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.85e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2074977 0.550 rs11085020 chr19:3446107 C/T cg08380311 chr19:3435252 NFIC -0.45 -5.96 -0.34 7.81e-9 Height; CESC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg24642844 chr7:1081250 C7orf50 -0.67 -8.0 -0.44 3.82e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08130813 chr19:46195655 QPCTL;SNRPD2 -0.42 -6.02 -0.35 5.85e-9 Fibrinogen levels; CESC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg11764359 chr7:65958608 NA 0.7 9.18 0.49 1.3e-17 Aortic root size; CESC cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg21573476 chr21:45109991 RRP1B -0.5 -7.01 -0.4 1.95e-11 Mean corpuscular volume; CESC cis rs6088580 0.634 rs1205338 chr20:32925625 C/G cg24642439 chr20:33292090 TP53INP2 -0.52 -6.79 -0.38 7.53e-11 Glomerular filtration rate (creatinine); CESC cis rs72945132 0.619 rs61887436 chr11:70243337 C/T cg14191688 chr11:70257035 CTTN 0.5 5.69 0.33 3.39e-8 Coronary artery disease; CESC cis rs644148 0.704 rs2686761 chr19:44989752 T/C cg15540054 chr19:45004280 ZNF180 -0.58 -6.26 -0.36 1.54e-9 Personality dimensions; CESC trans rs17685 0.796 rs3757594 chr7:75678644 G/A cg19862616 chr7:65841803 NCRNA00174 -0.82 -11.78 -0.59 5.04e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs4975709 0.959 rs9312959 chr5:1877008 G/A cg12288994 chr5:1860383 NA 0.37 6.14 0.35 3.01e-9 Cardiovascular disease risk factors; CESC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg02896835 chr1:92012615 NA -0.51 -6.62 -0.38 1.95e-10 Breast cancer; CESC cis rs15676 0.783 rs7044955 chr9:131567152 C/T cg00228799 chr9:131580591 ENDOG -0.49 -6.09 -0.35 3.93e-9 Blood metabolite levels; CESC cis rs9399137 0.507 rs4594969 chr6:135285586 A/T cg22676075 chr6:135203613 NA 0.53 6.87 0.39 4.46e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs11997175 0.935 rs6990082 chr8:33708034 C/A ch.8.33884649F chr8:33765107 NA 0.62 7.94 0.44 5.75e-14 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03917423 chr1:156339011 RHBG 0.6 6.75 0.38 9.51e-11 Gut microbiome composition (summer); CESC cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg24308560 chr3:49941425 MST1R -0.58 -8.09 -0.44 2.23e-14 Body mass index; CESC cis rs12681288 0.823 rs2701907 chr8:1003292 A/G cg04851639 chr8:1020857 NA -0.29 -6.26 -0.36 1.57e-9 Schizophrenia; CESC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg21782813 chr7:2030301 MAD1L1 0.44 6.13 0.35 3.23e-9 Bipolar disorder and schizophrenia; CESC cis rs2070997 0.667 rs2260323 chr9:133700786 C/T cg11464064 chr9:133710261 ABL1 -0.65 -7.37 -0.41 2.2e-12 Response to amphetamines; CESC trans rs7943203 1.000 rs10890839 chr11:108306236 C/A cg24643211 chr18:11851603 GNAL;CHMP1B -0.48 -6.14 -0.35 3.07e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs1801251 0.963 rs7562712 chr2:233606580 A/G cg08000102 chr2:233561755 GIGYF2 0.66 9.34 0.5 4.05e-18 Coronary artery disease; CESC cis rs1538970 0.962 rs9429160 chr1:45827968 G/T cg05343316 chr1:45956843 TESK2 0.83 11.22 0.57 3.55e-24 Platelet count; CESC cis rs7481584 0.961 rs12797969 chr11:3019216 C/T cg25174290 chr11:3078921 CARS -0.44 -5.4 -0.32 1.46e-7 Calcium levels; CESC cis rs1642645 0.872 rs238675 chr1:42470274 C/T cg16685388 chr1:42384056 HIVEP3 0.37 5.04 0.3 8.55e-7 Left ventricular obstructive tract defect (maternal effect); CESC cis rs4595586 0.566 rs7135104 chr12:39411086 C/T cg26384229 chr12:38710491 ALG10B 0.42 6.03 0.35 5.43e-9 Morning vs. evening chronotype; CESC cis rs9937943 0.667 rs12919002 chr16:74612377 A/G cg01733217 chr16:74700730 RFWD3 0.62 5.53 0.32 7.68e-8 Neutrophil percentage of white cells; CESC cis rs8062405 0.688 rs3924376 chr16:28925978 T/C cg05966235 chr16:28915196 ATP2A1 -0.4 -5.77 -0.33 2.23e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs9914544 0.602 rs4924929 chr17:18714241 G/A cg04702396 chr17:15466718 FAM18B2 0.52 6.42 0.37 6.21e-10 Educational attainment (years of education); CESC cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg14784868 chr12:69753453 YEATS4 0.87 13.54 0.64 4.34e-32 Cerebrospinal fluid biomarker levels; CESC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.96e-7 Life satisfaction; CESC cis rs9435341 0.965 rs2335077 chr1:107573565 A/G cg09367891 chr1:107599246 PRMT6 0.61 7.32 0.41 3.01e-12 Facial morphology (factor 21, depth of nasal alae); CESC cis rs2191566 0.960 rs11083733 chr19:44520919 G/C cg20607764 chr19:44506953 ZNF230 -0.58 -7.58 -0.42 5.8e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs4901869 0.966 rs425764 chr14:59334997 A/G cg02291164 chr14:59296302 NA 0.44 7.5 0.42 9.74e-13 Panic disorder; CESC cis rs9309473 0.579 rs6728128 chr2:73595982 T/C cg20560298 chr2:73613845 ALMS1 -0.49 -6.79 -0.39 7.27e-11 Metabolite levels; CESC cis rs2228479 0.850 rs17232630 chr16:89851179 C/T cg04013166 chr16:89971882 TCF25 0.78 6.68 0.38 1.43e-10 Skin colour saturation; CESC trans rs1814175 0.615 rs11040654 chr11:49939485 T/G cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16605187 chr1:156252484 TMEM79;SMG5 0.48 6.48 0.37 4.34e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg16339924 chr4:17578868 LAP3 0.64 8.09 0.44 2.21e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg06481639 chr22:41940642 POLR3H 0.59 5.84 0.34 1.51e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs12474201 0.928 rs12998762 chr2:46938393 A/C cg06386533 chr2:46925753 SOCS5 0.91 12.52 0.61 1.51e-28 Height; CESC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg14393609 chr7:65229607 NA 0.48 6.5 0.37 4e-10 Aortic root size; CESC cis rs12042938 0.600 rs1094655 chr1:231774362 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.41 5.48 0.32 9.81e-8 Neuranatomic and neurocognitive phenotypes; CESC cis rs2066819 1.000 rs2306694 chr12:56680636 C/T cg26714650 chr12:56694279 CS 1.52 10.39 0.54 1.95e-21 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23112213 chr5:137549144 CDC23 -0.59 -7.18 -0.4 6.86e-12 Gut microbiome composition (summer); CESC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg07701084 chr6:150067640 NUP43 0.42 5.77 0.33 2.22e-8 Lung cancer; CESC cis rs8177253 0.514 rs6790668 chr3:133442481 T/A cg16262614 chr3:133464971 TF 0.28 5.38 0.31 1.66e-7 Iron status biomarkers; CESC cis rs5753618 0.583 rs5753601 chr22:31798259 G/T cg02404636 chr22:31891804 SFI1 0.39 5.37 0.31 1.71e-7 Colorectal cancer; CESC cis rs10911251 0.546 rs7473 chr1:183114634 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 13.54 0.64 4.24e-32 Colorectal cancer; CESC cis rs1008375 0.866 rs2109518 chr4:17572162 G/A cg16339924 chr4:17578868 LAP3 0.74 9.62 0.51 5.34e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.88 0.52 8.11e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11098499 0.569 rs55845118 chr4:120290913 T/C cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22371845 chr8:140718096 NA 0.55 7.2 0.4 6.4e-12 Gut microbiota (bacterial taxa); CESC cis rs2243480 1.000 rs431076 chr7:65600320 A/C cg18252515 chr7:66147081 NA -1.42 -14.5 -0.67 1.8e-35 Diabetic kidney disease; CESC cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg08847533 chr14:75593920 NEK9 -0.93 -16.57 -0.71 8.58e-43 Height; CESC cis rs10899021 0.920 rs61901540 chr11:74314865 A/G cg25880958 chr11:74394337 NA -0.76 -7.95 -0.44 5.53e-14 Response to metformin (IC50); CESC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs6582630 0.513 rs1596446 chr12:38282160 C/T cg13010199 chr12:38710504 ALG10B -0.47 -5.85 -0.34 1.46e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs67311347 1.000 rs9841335 chr3:40475858 G/A cg01475735 chr3:40494733 NA -0.4 -5.08 -0.3 7.14e-7 Renal cell carcinoma; CESC cis rs1355223 0.902 rs1588353 chr11:34730814 A/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.33 -0.36 1.05e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg04944784 chr2:26401820 FAM59B -0.66 -7.53 -0.42 8.04e-13 Gut microbiome composition (summer); CESC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg06212747 chr3:49208901 KLHDC8B 0.72 10.88 0.56 4.82e-23 Menarche (age at onset); CESC cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.21e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9297145 0.715 rs62473008 chr7:98751541 A/G cg05967295 chr7:98741636 SMURF1 0.85 8.66 0.47 4.65e-16 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.67 0.47 4.35e-16 Colonoscopy-negative controls vs population controls; CESC trans rs2727020 0.688 rs11040338 chr11:49360601 A/G cg15704280 chr7:45808275 SEPT13 0.87 14.45 0.66 2.59e-35 Coronary artery disease; CESC trans rs1728785 0.901 rs1170437 chr16:68607943 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.67 8.11 0.45 1.92e-14 Ulcerative colitis; CESC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg23172400 chr8:95962367 TP53INP1 0.4 7.44 0.42 1.38e-12 Type 2 diabetes; CESC cis rs9611565 0.592 rs5751129 chr22:42015765 C/T cg06634786 chr22:41940651 POLR3H 0.54 5.94 0.34 8.8e-9 Vitiligo; CESC cis rs765787 0.530 rs2554454 chr15:45521536 A/G cg24006582 chr15:45444508 DUOX1 -0.48 -5.63 -0.33 4.5e-8 Uric acid levels; CESC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.78 0.8 5.33e-61 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04939749 chr2:178417898 TTC30B -0.6 -7.05 -0.4 1.56e-11 Gut microbiome composition (summer); CESC cis rs1348850 0.793 rs13020788 chr2:178480714 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.53 6.87 0.39 4.53e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs17401966 0.838 rs12737239 chr1:10323973 C/G cg15208524 chr1:10270712 KIF1B 0.39 5.07 0.3 7.62e-7 Hepatocellular carcinoma; CESC cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg10896456 chr17:42255109 ASB16;C17orf65 0.5 7.45 0.42 1.3e-12 Total body bone mineral density; CESC cis rs9911578 0.935 rs9893351 chr17:57023326 G/A cg12560992 chr17:57184187 TRIM37 0.8 12.5 0.61 1.75e-28 Intelligence (multi-trait analysis); CESC cis rs9325144 0.581 rs2730929 chr12:38942739 T/C cg13010199 chr12:38710504 ALG10B -0.51 -7.04 -0.4 1.64e-11 Morning vs. evening chronotype; CESC cis rs6460942 1.000 rs79964328 chr7:12319392 A/C cg20607287 chr7:12443886 VWDE -0.79 -8.51 -0.46 1.32e-15 Coronary artery disease; CESC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.27 0.31 2.8e-7 Menopause (age at onset); CESC cis rs71191701 1.000 rs71191701 chr9:139322257 G/C cg14019695 chr9:139328340 INPP5E 0.4 5.14 0.3 5.37e-7 Myeloid white cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; CESC cis rs61841072 0.961 rs73113549 chr1:243126414 A/G cg02356786 chr1:243265016 LOC731275 0.4 5.07 0.3 7.42e-7 Schizophrenia; CESC trans rs208520 1.000 rs9453663 chr6:66976077 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 7.87 0.44 9.16e-14 Exhaled nitric oxide output; CESC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg27121462 chr16:89883253 FANCA 0.81 12.1 0.6 4e-27 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07644571 chr22:22307395 PPM1F 0.63 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg18446336 chr7:2847575 GNA12 -0.34 -5.4 -0.31 1.49e-7 Height; CESC cis rs701145 0.556 rs355771 chr3:154039385 G/C cg16511985 chr3:153974050 SGEF 0.41 5.76 0.33 2.38e-8 Coronary artery disease; CESC cis rs5750830 0.594 rs9611166 chr22:39775268 T/C cg11247378 chr22:39784982 NA -0.51 -7.72 -0.43 2.36e-13 Intelligence (multi-trait analysis); CESC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg04414720 chr1:150670196 GOLPH3L 0.52 6.88 0.39 4.32e-11 Melanoma; CESC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9788682 1.000 rs9788682 chr15:78802586 A/G cg24631222 chr15:78858424 CHRNA5 -0.82 -10.99 -0.56 2.06e-23 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg22344139 chr1:44435583 DPH2 -0.49 -6.44 -0.37 5.56e-10 Height; CESC cis rs17253792 0.822 rs8007065 chr14:56081272 A/G cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg02935154 chr7:12443704 VWDE -0.6 -6.82 -0.39 6.02e-11 Coronary artery disease; CESC trans rs1814175 0.817 rs1851858 chr11:49855638 G/A cg03929089 chr4:120376271 NA -0.92 -15.77 -0.7 5.68e-40 Height; CESC cis rs10779751 1.000 rs7526649 chr1:11278163 C/T cg08854313 chr1:11322531 MTOR 0.77 10.45 0.54 1.23e-21 Body mass index; CESC cis rs66573146 0.656 rs56094305 chr4:6956086 C/T cg00086871 chr4:6988644 TBC1D14 1.05 6.88 0.39 4.25e-11 Granulocyte percentage of myeloid white cells; CESC cis rs10504229 0.636 rs115738451 chr8:58055133 A/T cg02725872 chr8:58115012 NA -0.43 -6.2 -0.36 2.16e-9 Developmental language disorder (linguistic errors); CESC cis rs2637266 0.905 rs7076442 chr10:78360480 A/C cg18941641 chr10:78392320 NA -0.35 -6.24 -0.36 1.74e-9 Pulmonary function; CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg23131131 chr22:24373011 LOC391322 -0.71 -9.76 -0.51 2.07e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9814567 0.896 rs7653880 chr3:134345788 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.67 -0.33 3.63e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg15383120 chr6:291909 DUSP22 -0.69 -8.92 -0.48 7.68e-17 Menopause (age at onset); CESC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg12311346 chr5:56204834 C5orf35 -0.4 -5.16 -0.3 4.91e-7 Breast cancer;Breast cancer (early onset); CESC cis rs2836633 0.929 rs2836602 chr21:40039169 A/T cg12884169 chr21:40033163 ERG -0.36 -5.88 -0.34 1.2e-8 Coronary artery disease; CESC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg11890956 chr21:40555474 PSMG1 1.18 22.96 0.82 5.84e-65 Cognitive function; CESC cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg24308560 chr3:49941425 MST1R 0.63 9.25 0.49 7.75e-18 Intelligence (multi-trait analysis); CESC cis rs933688 1.000 rs6869717 chr5:90694797 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.87 0.59 2.36e-26 Smoking behavior; CESC cis rs10465746 0.967 rs11163868 chr1:84397013 T/G cg10977910 chr1:84465055 TTLL7 0.46 6.29 0.36 1.29e-9 Obesity-related traits; CESC cis rs7312933 0.558 rs1051453 chr12:42852217 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 5.92 0.34 9.98e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg21285383 chr16:89894308 SPIRE2 0.31 5.6 0.33 5.44e-8 Vitiligo; CESC cis rs6545883 0.929 rs6545877 chr2:61741947 T/C cg15711740 chr2:61764176 XPO1 -0.44 -5.4 -0.31 1.47e-7 Tuberculosis; CESC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg09699651 chr6:150184138 LRP11 0.4 5.18 0.3 4.32e-7 Lung cancer; CESC cis rs1348850 0.668 rs13034886 chr2:178493301 G/T cg23306229 chr2:178417860 TTC30B 0.54 6.33 0.36 1.02e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs7927592 0.731 rs10896350 chr11:68386373 A/C cg20283391 chr11:68216788 NA -0.42 -5.09 -0.3 6.65e-7 Total body bone mineral density; CESC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7429990 0.965 rs777015 chr3:47937072 A/G cg11946769 chr3:48343235 NME6 0.42 5.27 0.31 2.89e-7 Educational attainment (years of education); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24830314 chr6:83775579 UBE2CBP -0.39 -6.16 -0.35 2.62e-9 Gambling; CESC cis rs9768139 0.733 rs13309363 chr7:158122179 C/A cg27057461 chr7:158136379 PTPRN2 -0.35 -5.43 -0.32 1.27e-7 Calcium levels; CESC trans rs9467711 0.606 rs9393714 chr6:26373740 G/T cg06606381 chr12:133084897 FBRSL1 -0.76 -7.09 -0.4 1.23e-11 Autism spectrum disorder or schizophrenia; CESC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg26528311 chr1:38462546 FHL3 0.36 5.86 0.34 1.34e-8 Coronary artery disease; CESC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg23131131 chr22:24373011 LOC391322 0.56 7.44 0.42 1.4e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9611565 0.512 rs4820446 chr22:42215684 C/T cg17376030 chr22:41985996 PMM1 0.76 8.01 0.44 3.63e-14 Vitiligo; CESC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg03452623 chr4:187889614 NA -0.86 -14.21 -0.66 1.82e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs4006360 0.614 rs6416914 chr17:39262850 A/G cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.41 -5.18 -0.3 4.33e-7 Bipolar disorder and schizophrenia; CESC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs1030877 0.515 rs3828300 chr2:105901107 G/A cg02079111 chr2:105885981 TGFBRAP1 -0.51 -6.37 -0.36 8.17e-10 Obesity-related traits; CESC cis rs7116495 0.609 rs4944243 chr11:71674354 T/C cg18441811 chr11:71824068 C11orf51 -0.81 -5.3 -0.31 2.48e-7 Severe influenza A (H1N1) infection; CESC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs11608355 0.545 rs2302709 chr12:109893697 A/G cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.06 0.35 4.63e-9 Bipolar disorder; CESC cis rs6088590 1.000 rs10048849 chr20:33419680 C/T cg06115741 chr20:33292138 TP53INP2 0.61 7.6 0.42 5.11e-13 Coronary artery disease; CESC cis rs9462846 0.841 rs66541797 chr6:42825942 C/T cg02353165 chr6:42928485 GNMT 0.47 5.48 0.32 1.01e-7 Blood protein levels; CESC cis rs6429082 0.818 rs291386 chr1:235647050 C/T cg26050004 chr1:235667680 B3GALNT2 0.61 7.62 0.42 4.63e-13 Adiposity; CESC trans rs2727020 0.595 rs7924311 chr11:49507573 G/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.43 -0.71 2.51e-42 Coronary artery disease; CESC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.03 -0.35 5.62e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs12824058 0.831 rs4759450 chr12:130812732 G/A cg26677194 chr12:130822605 PIWIL1 0.51 6.72 0.38 1.13e-10 Menopause (age at onset); CESC cis rs9303401 0.538 rs8078280 chr17:56473132 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.91 10.78 0.55 1.02e-22 Cognitive test performance; CESC cis rs506597 0.850 rs221774 chr7:100298984 A/G cg10426581 chr7:100472382 SRRT -0.66 -5.15 -0.3 5.14e-7 Pursuit maintenance gain in psychotic disorders; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26742440 chr11:73472391 RAB6A 0.48 6.03 0.35 5.41e-9 Gut microbiota (bacterial taxa); CESC cis rs701145 0.556 rs355756 chr3:154021063 G/A cg16511985 chr3:153974050 SGEF 0.43 6.1 0.35 3.71e-9 Coronary artery disease; CESC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.64 0.47 5.42e-16 Electroencephalogram traits; CESC cis rs1003719 0.715 rs7280251 chr21:38567911 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.61e-15 Eye color traits; CESC cis rs892961 0.932 rs7216116 chr17:75405078 C/T cg05865280 chr17:75406074 SEPT9 0.59 10.95 0.56 2.82e-23 Airflow obstruction; CESC cis rs9303401 0.614 rs56284918 chr17:57178838 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.88 11.1 0.56 8.94e-24 Cognitive test performance; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg21237687 chr17:6899380 ALOX12 -0.52 -9.09 -0.49 2.38e-17 Tonsillectomy; CESC cis rs10781543 0.839 rs10870071 chr9:139382184 T/C cg14169450 chr9:139327907 INPP5E 0.49 7.53 0.42 7.75e-13 Monocyte percentage of white cells; CESC cis rs3820068 0.603 rs59475085 chr1:15911131 G/A cg17385448 chr1:15911702 AGMAT 0.43 6.67 0.38 1.45e-10 Systolic blood pressure; CESC trans rs28549925 0.590 rs17136920 chr7:16991550 G/A cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.83e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs2066819 1.000 rs79101914 chr12:56729739 A/G cg26734620 chr12:56694298 CS 0.98 5.95 0.34 8.45e-9 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26239930 chr14:52455994 C14orf166 -0.65 -8.09 -0.45 2.15e-14 Gut microbiome composition (summer); CESC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg21724239 chr8:58056113 NA 0.63 5.77 0.33 2.16e-8 Developmental language disorder (linguistic errors); CESC cis rs5769707 0.967 rs2071904 chr22:50034477 C/T cg05373962 chr22:49881684 NA -0.4 -6.91 -0.39 3.65e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg08859206 chr1:53392774 SCP2 -0.54 -7.18 -0.4 7e-12 Monocyte count; CESC cis rs1707322 1.000 rs785469 chr1:46521091 C/T cg03146154 chr1:46216737 IPP -0.72 -9.73 -0.51 2.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg21951975 chr1:209979733 IRF6 0.59 7.16 0.4 8.01e-12 Cleft lip with or without cleft palate; CESC cis rs3820928 1.000 rs4673173 chr2:227769493 A/C cg11843606 chr2:227700838 RHBDD1 -0.44 -5.9 -0.34 1.09e-8 Pulmonary function; CESC cis rs12618769 0.543 rs72819980 chr2:99040522 A/G cg10123293 chr2:99228465 UNC50 0.41 5.43 0.32 1.27e-7 Bipolar disorder; CESC cis rs11098499 0.657 rs71614442 chr4:120379346 C/T cg24375607 chr4:120327624 NA 0.45 5.54 0.32 7.19e-8 Corneal astigmatism; CESC cis rs763121 0.853 rs2281021 chr22:39064667 T/C cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.58e-7 Menopause (age at onset); CESC cis rs2439831 0.702 rs8033995 chr15:44013509 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.73 8.48 0.46 1.6e-15 Lung cancer in ever smokers; CESC cis rs3741151 1.000 rs112628073 chr11:73013626 C/T cg17517138 chr11:73019481 ARHGEF17 1.2 8.42 0.46 2.32e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs36051895 0.664 rs2274649 chr9:5090934 A/T cg02405213 chr9:5042618 JAK2 -0.51 -5.94 -0.34 9.11e-9 Pediatric autoimmune diseases; CESC cis rs11122272 0.705 rs2491411 chr1:231533448 C/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs7589342 0.598 rs7602442 chr2:106402795 C/T cg16077055 chr2:106428750 NCK2 -0.36 -5.17 -0.3 4.61e-7 Addiction; CESC trans rs1814175 0.708 rs10839464 chr11:49981386 T/C cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.85e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg08888203 chr3:10149979 C3orf24 0.49 6.07 0.35 4.32e-9 Alzheimer's disease; CESC cis rs9914988 0.943 rs4795459 chr17:27113726 G/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg05283184 chr6:79620031 NA -0.41 -6.38 -0.36 7.79e-10 Intelligence (multi-trait analysis); CESC cis rs12476592 0.602 rs4671516 chr2:63790555 G/T cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs17253792 0.822 rs77990307 chr14:56070049 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs7192750 0.617 rs9929256 chr16:72040032 A/C cg14768367 chr16:72042858 DHODH 0.82 6.22 0.36 1.94e-9 LDL cholesterol levels;Total cholesterol levels; CESC cis rs713587 0.713 rs4665276 chr2:25213333 C/T cg01884057 chr2:25150051 NA -0.38 -7.17 -0.4 7.39e-12 Body mass index in non-asthmatics; CESC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg26338869 chr17:61819248 STRADA 0.68 8.97 0.48 5.62e-17 Prudent dietary pattern; CESC cis rs35306767 0.903 rs12764024 chr10:922861 A/G cg25019033 chr10:957182 NA -0.51 -5.69 -0.33 3.3e-8 Eosinophil percentage of granulocytes; CESC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Parkinson's disease; CESC cis rs11098499 0.863 rs3775843 chr4:120427844 T/C cg09307838 chr4:120376055 NA 0.95 13.11 0.63 1.3e-30 Corneal astigmatism; CESC cis rs17407555 0.821 rs17198197 chr4:10139157 A/G cg11266682 chr4:10021025 SLC2A9 0.53 5.64 0.33 4.44e-8 Schizophrenia (age at onset); CESC cis rs7259376 0.936 rs6511350 chr19:22594697 A/G cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.94e-7 Menopause (age at onset); CESC cis rs66887589 0.616 rs11098498 chr4:120187119 T/C cg09307838 chr4:120376055 NA 0.69 9.61 0.51 5.93e-19 Diastolic blood pressure; CESC cis rs2841277 0.509 rs11850949 chr14:105408827 A/C cg17340268 chr14:105411764 AHNAK2 -0.53 -6.97 -0.39 2.57e-11 Rheumatoid arthritis; CESC cis rs950169 0.922 rs12911223 chr15:84831671 G/A cg17507749 chr15:85114479 UBE2QP1 -0.55 -6.25 -0.36 1.66e-9 Schizophrenia; CESC cis rs2404602 0.692 rs56193230 chr15:76934472 C/T cg22467129 chr15:76604101 ETFA -0.36 -5.24 -0.31 3.26e-7 Blood metabolite levels; CESC cis rs7605827 0.930 rs1024869 chr2:15549043 G/C cg19274914 chr2:15703543 NA 0.34 6.12 0.35 3.38e-9 Educational attainment (years of education); CESC cis rs9457247 0.935 rs2149093 chr6:167373045 T/C cg25258033 chr6:167368657 RNASET2 -0.4 -6.05 -0.35 4.91e-9 Crohn's disease; CESC cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg00255919 chr5:131827918 IRF1 0.51 8.68 0.47 4.19e-16 Asthma (sex interaction); CESC cis rs7917772 0.582 rs7087984 chr10:104380686 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.38 5.18 0.3 4.44e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs4243830 0.850 rs12760251 chr1:6601336 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.88 -8.87 -0.48 1.12e-16 Body mass index; CESC cis rs597583 0.715 rs4938399 chr11:117398399 C/T cg27161313 chr11:117392002 DSCAML1 -0.54 -6.37 -0.36 8.18e-10 Putamen volume; CESC cis rs763121 0.853 rs2064088 chr22:39053382 A/G cg14440974 chr22:39074834 NA -0.4 -5.49 -0.32 9.53e-8 Menopause (age at onset); CESC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg24562669 chr7:97807699 LMTK2 0.51 7.35 0.41 2.45e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs72772090 0.539 rs114006288 chr5:96118004 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.21 -0.3 3.74e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs826838 0.967 rs73096706 chr12:38860563 G/A cg26384229 chr12:38710491 ALG10B 0.83 14.35 0.66 6.2e-35 Heart rate; CESC cis rs1185460 0.967 rs1184902 chr11:118945337 A/G cg23280166 chr11:118938394 VPS11 0.58 7.73 0.43 2.18e-13 Coronary artery disease; CESC cis rs931127 0.505 rs2306362 chr11:65405510 G/T cg27068330 chr11:65405492 SIPA1 -0.51 -5.58 -0.32 5.94e-8 Systemic lupus erythematosus; CESC cis rs2290159 0.848 rs6771385 chr3:12639419 A/G cg23032965 chr3:12705835 RAF1 0.49 5.45 0.32 1.14e-7 Cholesterol, total; CESC cis rs12410462 0.681 rs113316536 chr1:227547033 T/G cg04117972 chr1:227635322 NA 0.62 5.31 0.31 2.27e-7 Major depressive disorder; CESC cis rs1976403 0.659 rs10799699 chr1:21820961 C/T cg21906605 chr1:21766650 NBPF3 0.41 5.39 0.31 1.59e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs4629180 0.917 rs34217240 chr2:102136682 G/A cg01388757 chr2:102091195 RFX8 0.41 6.05 0.35 4.87e-9 Chronic rhinosinusitis with nasal polyps; CESC cis rs7296418 0.517 rs73231928 chr12:123724325 T/C cg00376283 chr12:123451042 ABCB9 0.63 8.78 0.47 2.04e-16 Platelet count; CESC cis rs6426558 0.515 rs7412928 chr1:227332148 C/T cg10327440 chr1:227177885 CDC42BPA -0.47 -5.69 -0.33 3.4e-8 Neutrophil percentage of white cells; CESC cis rs28374715 0.662 rs16971558 chr15:41458619 G/A cg18705301 chr15:41695430 NDUFAF1 -0.79 -10.4 -0.54 1.82e-21 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02260482 chr12:104359603 TDG 0.7 8.3 0.45 5.28e-15 Gut microbiome composition (summer); CESC trans rs875971 1.000 rs35149210 chr7:65929925 T/C cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs1506636 1.000 rs7779099 chr7:123295964 C/T cg03229431 chr7:123269106 ASB15 -0.53 -6.83 -0.39 5.87e-11 Plateletcrit;Platelet count; CESC cis rs950169 0.614 rs12911536 chr15:84673030 G/T cg17507749 chr15:85114479 UBE2QP1 0.6 5.93 0.34 9.65e-9 Schizophrenia; CESC cis rs72781680 0.846 rs55770503 chr2:24030126 A/T cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22505778 chr3:113822317 NA -0.68 -7.95 -0.44 5.27e-14 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.37 -0.5 3.35e-18 Alzheimer's disease; CESC trans rs78049276 0.736 rs77028772 chr4:148364920 G/A cg13149281 chr14:23389818 RBM23;PRMT5 -0.62 -6.35 -0.36 9.55e-10 Pulse pressure; CESC cis rs17401966 1.000 rs12734551 chr1:10391536 A/C cg15208524 chr1:10270712 KIF1B 0.5 6.48 0.37 4.52e-10 Hepatocellular carcinoma; CESC cis rs939658 0.805 rs11630571 chr15:79432992 C/A cg17916960 chr15:79447300 NA -0.38 -6.3 -0.36 1.21e-9 Refractive error; CESC cis rs763121 0.853 rs9622833 chr22:39000397 G/A cg06544989 chr22:39130855 UNC84B 0.49 8.25 0.45 7.34e-15 Menopause (age at onset); CESC cis rs2933343 0.553 rs789212 chr3:128686912 A/C cg25356066 chr3:128598488 ACAD9 0.56 6.85 0.39 5.2e-11 IgG glycosylation; CESC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg18404041 chr3:52824283 ITIH1 0.45 7.25 0.41 4.7e-12 Bipolar disorder; CESC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg11742103 chr11:62369870 EML3;MTA2 0.55 7.97 0.44 4.71e-14 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs412050 0.649 rs117808805 chr22:22246629 C/T cg17089214 chr22:22089827 YPEL1 0.71 6.13 0.35 3.09e-9 Attention deficit hyperactivity disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08744097 chr16:1550264 TELO2 0.51 7.11 0.4 1.09e-11 Fibrinogen levels; CESC cis rs11587400 0.574 rs2268696 chr1:115219083 T/A cg12756093 chr1:115239321 AMPD1 -0.45 -6.18 -0.35 2.42e-9 Autism; CESC cis rs12765878 1.000 rs11191846 chr10:105649813 A/G cg24587175 chr10:105670608 OBFC1 0.32 5.36 0.31 1.81e-7 Coronary artery disease; CESC cis rs9487051 0.768 rs9480910 chr6:109521707 T/C cg01475377 chr6:109611718 NA -0.46 -6.93 -0.39 3.18e-11 Reticulocyte fraction of red cells; CESC cis rs6998277 0.830 rs6468838 chr8:103609336 T/C cg10187029 chr8:103597600 NA 0.73 9.39 0.5 2.94e-18 Migraine; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02442526 chr22:46973514 NA -0.5 -6.49 -0.37 4.14e-10 Fibrinogen levels; CESC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs7267979 0.932 rs6132848 chr20:25561645 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.73 12.77 0.62 1.93e-29 Liver enzyme levels (alkaline phosphatase); CESC cis rs9300255 0.602 rs1727306 chr12:123665695 A/G cg00376283 chr12:123451042 ABCB9 0.71 8.71 0.47 3.27e-16 Neutrophil percentage of white cells; CESC cis rs7208859 0.673 rs9913782 chr17:29237384 A/G cg19761014 chr17:28927070 LRRC37B2 0.71 5.63 0.33 4.48e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15936439 chr13:20767183 GJB2 0.55 6.19 0.36 2.26e-9 Gut microbiome composition (summer); CESC cis rs2274273 0.588 rs7158791 chr14:55828607 A/G cg04306507 chr14:55594613 LGALS3 0.3 5.26 0.31 2.92e-7 Protein biomarker; CESC cis rs2404602 0.503 rs284909 chr15:76736628 C/T cg00316803 chr15:76480434 C15orf27 -0.39 -5.88 -0.34 1.25e-8 Blood metabolite levels; CESC cis rs7772486 0.754 rs6910790 chr6:146255330 G/A cg23711669 chr6:146136114 FBXO30 -0.92 -13.3 -0.63 2.94e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.43 0.32 1.27e-7 Depression; CESC cis rs8027181 0.839 rs8025333 chr15:73025121 A/G cg25632853 chr15:73088954 NA 0.31 5.46 0.32 1.1e-7 Triglyceride levels; CESC cis rs67397200 0.632 rs11666308 chr19:17437744 T/C cg22549504 chr19:17448937 GTPBP3 0.51 6.35 0.36 9.42e-10 Breast cancer;Breast Cancer in BRCA1 mutation carriers;Breast cancer (estrogen-receptor negative); CESC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg22535103 chr8:58192502 C8orf71 -0.81 -9.14 -0.49 1.65e-17 Developmental language disorder (linguistic errors); CESC cis rs3780486 0.505 rs10758188 chr9:33123386 C/T cg13443165 chr9:33130375 B4GALT1 -0.47 -7.06 -0.4 1.49e-11 IgG glycosylation; CESC cis rs9910055 0.529 rs368328 chr17:42170289 G/A cg13607699 chr17:42295918 UBTF -0.44 -5.3 -0.31 2.41e-7 Total body bone mineral density; CESC cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg05347473 chr6:146136440 FBXO30 -0.57 -7.53 -0.42 8.04e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs12477438 0.684 rs6756880 chr2:99676991 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs11711311 1.000 rs9288983 chr3:113488699 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.68 9.34 0.5 4.24e-18 IgG glycosylation; CESC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg03188948 chr7:1209495 NA 0.73 7.02 0.4 1.85e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs72781680 0.716 rs2712056 chr2:23959131 C/T cg08917208 chr2:24149416 ATAD2B 0.61 5.92 0.34 9.71e-9 Lymphocyte counts; CESC cis rs9457247 0.508 rs9457268 chr6:167503639 A/T cg07741184 chr6:167504864 NA 0.33 5.73 0.33 2.76e-8 Crohn's disease; CESC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg27170947 chr2:26402098 FAM59B -0.6 -7.25 -0.41 4.7e-12 Gut microbiome composition (summer); CESC cis rs9522267 0.535 rs4644738 chr13:112235995 G/A cg10483660 chr13:112241077 NA -0.33 -5.78 -0.33 2.14e-8 Hepatitis; CESC cis rs116095464 0.558 rs10057626 chr5:239720 T/G cg22496380 chr5:211416 CCDC127 -0.75 -8.78 -0.47 2.13e-16 Breast cancer; CESC cis rs2011503 0.882 rs4808933 chr19:19363812 T/A cg20644253 chr19:19431407 KIAA0892;SF4 0.54 5.73 0.33 2.76e-8 Bipolar disorder; CESC trans rs6964833 0.935 rs34630792 chr7:74061197 G/C cg07504079 chr7:72649617 NCF1B -0.54 -6.15 -0.35 2.87e-9 Menarche (age at onset); CESC cis rs3820068 0.581 rs16851841 chr1:15922713 A/G cg13390004 chr1:15929781 NA 0.34 5.3 0.31 2.41e-7 Systolic blood pressure; CESC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.51 -0.32 8.3e-8 Aortic root size; CESC cis rs9487051 0.676 rs6568566 chr6:109596792 G/A cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC cis rs6502050 0.871 rs8080366 chr17:80067298 A/G cg23985595 chr17:80112537 CCDC57 0.35 5.44 0.32 1.24e-7 Life satisfaction; CESC cis rs2737618 0.674 rs2258280 chr1:200097648 G/A cg21825944 chr1:200113062 NR5A2 -0.42 -6.21 -0.36 2.01e-9 Uric acid levels; CESC cis rs13082711 0.911 rs13077400 chr3:27473066 A/G cg02860705 chr3:27208620 NA 0.5 6.54 0.37 3.15e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs2072499 0.695 rs112223391 chr1:156156094 G/A cg25208724 chr1:156163844 SLC25A44 1.0 12.73 0.62 2.65e-29 Testicular germ cell tumor; CESC cis rs4629180 0.586 rs290773 chr2:102125930 G/A cg04415270 chr2:102091202 RFX8 0.35 5.91 0.34 1.02e-8 Chronic rhinosinusitis with nasal polyps; CESC cis rs13082711 0.558 rs1844983 chr3:27370203 C/T cg02860705 chr3:27208620 NA -0.51 -6.63 -0.38 1.88e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7927771 1.000 rs4752797 chr11:47874364 C/T cg20307385 chr11:47447363 PSMC3 -0.44 -5.41 -0.32 1.43e-7 Subjective well-being; CESC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg08859206 chr1:53392774 SCP2 -0.62 -8.41 -0.46 2.57e-15 Monocyte count; CESC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.93 10.15 0.53 1.2e-20 Platelet count; CESC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg11644478 chr21:40555479 PSMG1 0.94 13.54 0.64 4.14e-32 Cognitive function; CESC trans rs744016 0.645 rs5761630 chr22:27006698 A/G cg26539023 chr1:201369031 LAD1 -0.4 -6.02 -0.35 5.67e-9 RR interval (heart rate); CESC trans rs9325144 0.671 rs7486919 chr12:38767997 A/G cg10679878 chr6:156759499 NA -0.34 -6.09 -0.35 4.05e-9 Morning vs. evening chronotype; CESC cis rs9457247 0.967 rs424185 chr6:167410907 C/T cg25258033 chr6:167368657 RNASET2 0.4 6.14 0.35 2.93e-9 Crohn's disease; CESC cis rs2933343 0.649 rs789214 chr3:128594995 A/G cg25356066 chr3:128598488 ACAD9 0.63 8.94 0.48 6.95e-17 IgG glycosylation; CESC cis rs6831352 0.842 rs1230156 chr4:99989626 C/T cg21548116 chr4:100009993 ADH5 0.52 5.43 0.32 1.27e-7 Alcohol dependence; CESC cis rs67478160 0.643 rs7156697 chr14:104211136 G/A cg08213375 chr14:104286397 PPP1R13B 0.54 10.85 0.55 6.32e-23 Schizophrenia; CESC trans rs7615952 0.688 rs12638240 chr3:125541238 G/A cg07211511 chr3:129823064 LOC729375 -0.84 -9.55 -0.51 9.43e-19 Blood pressure (smoking interaction); CESC cis rs11190604 0.943 rs11190568 chr10:102224277 C/T cg07080220 chr10:102295463 HIF1AN 0.58 5.27 0.31 2.81e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs3733585 0.673 rs4235348 chr4:9951968 T/C cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs12476592 0.571 rs4671505 chr2:63644303 G/T cg17519650 chr2:63277830 OTX1 -0.47 -5.26 -0.31 2.99e-7 Childhood ear infection; CESC cis rs2180341 0.597 rs11154397 chr6:127646649 G/C cg24812749 chr6:127587940 RNF146 0.6 8.02 0.44 3.42e-14 Breast cancer; CESC cis rs9322193 0.607 rs12204653 chr6:150213021 C/G cg01145232 chr6:150245071 RAET1G 0.5 6.22 0.36 1.92e-9 Lung cancer; CESC trans rs11088226 0.581 rs2236430 chr21:33973408 A/G cg09050820 chr6:167586206 TCP10L2 -0.49 -6.22 -0.36 1.97e-9 Gastritis; CESC cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 12.62 0.61 6.8e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs16854884 0.586 rs6782789 chr3:143746691 G/A cg06585982 chr3:143692056 C3orf58 0.51 6.92 0.39 3.46e-11 Economic and political preferences (feminism/equality); CESC cis rs3806843 0.619 rs2569160 chr5:140028774 T/C cg16179182 chr5:140090404 VTRNA1-1 0.42 5.45 0.32 1.17e-7 Depressive symptoms (multi-trait analysis); CESC cis rs858239 0.932 rs858272 chr7:23276785 A/G cg23682824 chr7:23144976 KLHL7 0.47 6.37 0.36 8.19e-10 Cerebrospinal fluid biomarker levels; CESC cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg06577658 chr19:46296270 DMWD 0.42 5.03 0.3 9.2e-7 Coronary artery disease; CESC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg22823121 chr1:150693482 HORMAD1 0.39 5.47 0.32 1.05e-7 Melanoma; CESC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg20151795 chr6:28129481 ZNF389 0.41 5.3 0.31 2.46e-7 Depression; CESC trans rs1116547 0.531 rs73247445 chr5:112848230 G/A cg10115368 chr14:100435663 NA 0.52 6.13 0.35 3.21e-9 Cerebral amyloid angiopathy; CESC cis rs4654899 0.772 rs61778530 chr1:21087363 G/C cg05370193 chr1:21551575 ECE1 0.34 5.04 0.3 8.63e-7 Superior frontal gyrus grey matter volume; CESC cis rs6061231 0.798 rs2427308 chr20:60969451 C/T cg22601191 chr20:60968625 CABLES2 0.53 6.24 0.36 1.73e-9 Colorectal cancer; CESC cis rs3741798 0.908 rs61922046 chr12:12495675 A/T cg08615371 chr12:12503544 MANSC1 0.86 6.13 0.35 3.12e-9 Cerebrospinal fluid biomarker levels; CESC cis rs6893300 0.785 rs6887507 chr5:179186237 A/G cg14593053 chr5:179126677 CANX -0.49 -5.79 -0.34 1.94e-8 Resting heart rate; CESC cis rs225245 0.782 rs178649 chr17:33908197 C/G cg05299278 chr17:33885742 SLFN14 0.36 5.18 0.3 4.4e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs10089 1.000 rs17764954 chr5:127514436 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 9.61 0.51 5.97e-19 Ileal carcinoids; CESC cis rs17764205 0.777 rs10424519 chr19:3253532 C/G cg02612712 chr19:3985498 EEF2 -0.63 -5.17 -0.3 4.69e-7 Bipolar disorder and schizophrenia; CESC cis rs2070488 0.775 rs6599208 chr3:38558104 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.78 -12.57 -0.61 9.53e-29 Electrocardiographic conduction measures; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24528297 chr14:103995361 TRMT61A -0.43 -6.0 -0.35 6.29e-9 Gambling; CESC cis rs6061231 0.505 rs13037253 chr20:60928724 G/A cg22307297 chr20:60903441 LAMA5 0.38 5.26 0.31 3.03e-7 Colorectal cancer; CESC cis rs7772486 0.686 rs6933161 chr6:146081369 G/A cg05347473 chr6:146136440 FBXO30 -0.52 -6.86 -0.39 4.95e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg20573242 chr4:122745356 CCNA2 0.54 6.55 0.37 3.06e-10 Type 2 diabetes; CESC cis rs9287719 0.967 rs12692417 chr2:10745718 C/G cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC cis rs2228479 0.850 rs3785281 chr16:89824263 G/C cg00800038 chr16:89945340 TCF25 -0.92 -7.67 -0.43 3.37e-13 Skin colour saturation; CESC cis rs4908768 0.501 rs7530745 chr1:8557691 A/C cg00120948 chr1:8484417 RERE -0.34 -5.29 -0.31 2.61e-7 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CESC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg18350739 chr11:68623251 NA -0.46 -7.02 -0.4 1.88e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs561341 1.000 rs564714 chr17:30318404 C/T cg12193833 chr17:30244370 NA -0.76 -6.95 -0.39 2.87e-11 Hip circumference adjusted for BMI; CESC cis rs2832077 0.506 rs2832085 chr21:30155258 G/T cg24692254 chr21:30365293 RNF160 -0.49 -5.86 -0.34 1.34e-8 Cognitive test performance; CESC cis rs1707322 0.752 rs11211146 chr1:46109794 T/C cg06784218 chr1:46089804 CCDC17 0.4 7.04 0.4 1.69e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3126085 0.935 rs6587666 chr1:152296863 C/T cg03465714 chr1:152285911 FLG 0.5 5.71 0.33 2.96e-8 Atopic dermatitis; CESC cis rs950776 0.507 rs12912673 chr15:78810216 T/C cg24631222 chr15:78858424 CHRNA5 -0.4 -5.09 -0.3 6.79e-7 Sudden cardiac arrest; CESC cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15369419 chr2:207945905 KLF7 0.48 6.3 0.36 1.21e-9 Fibrinogen levels; CESC cis rs4474465 0.790 rs10751295 chr11:78266047 T/A cg27205649 chr11:78285834 NARS2 0.44 5.65 0.33 4.22e-8 Alzheimer's disease (survival time); CESC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg18301423 chr5:131593218 PDLIM4 0.38 5.54 0.32 7.36e-8 Breast cancer; CESC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.24 0.53 6.03e-21 Prudent dietary pattern; CESC cis rs7927771 1.000 rs12363232 chr11:47623890 C/T cg18512352 chr11:47633146 NA -0.6 -9.08 -0.49 2.54e-17 Subjective well-being; CESC cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg07636037 chr3:49044803 WDR6 1.05 19.61 0.77 1.63e-53 Parkinson's disease; CESC cis rs616402 0.527 rs11121581 chr1:10577740 A/G cg20482658 chr1:10539492 PEX14 -0.29 -5.94 -0.34 8.75e-9 Breast size; CESC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Tonsillectomy; CESC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg27170947 chr2:26402098 FAM59B 0.73 8.33 0.46 4.5e-15 Gut microbiome composition (summer); CESC cis rs4930561 0.714 rs7950452 chr11:67962407 C/A cg16338278 chr11:67432957 ALDH3B2 0.42 5.27 0.31 2.77e-7 Breast cancer in childhood cancer survivors;IgG glycosylation; CESC cis rs2479724 0.901 rs6458244 chr6:41790455 C/T cg08135965 chr6:41755394 TOMM6 -0.43 -5.87 -0.34 1.29e-8 Menarche (age at onset); CESC cis rs858239 0.601 rs6969733 chr7:23168377 T/C cg23682824 chr7:23144976 KLHL7 0.54 7.37 0.41 2.14e-12 Cerebrospinal fluid biomarker levels; CESC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg07701084 chr6:150067640 NUP43 0.42 5.71 0.33 3.08e-8 Lung cancer; CESC cis rs11122272 0.735 rs2749716 chr1:231486908 T/C cg06096015 chr1:231504339 EGLN1 0.42 6.05 0.35 4.99e-9 Hemoglobin concentration; CESC trans rs801193 0.805 rs12532355 chr7:66070584 C/G cg26939375 chr7:64535504 NA -0.54 -7.43 -0.42 1.52e-12 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10451977 chr15:45507901 NA -0.66 -7.4 -0.41 1.81e-12 Gut microbiome composition (summer); CESC trans rs35110281 0.591 rs86139 chr21:44932802 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.62 0.38 2.03e-10 Mean corpuscular volume; CESC cis rs2276314 0.857 rs28396546 chr18:33639024 T/C cg19628046 chr18:33552617 C18orf21 0.5 5.49 0.32 9.61e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs11997175 0.624 rs4733175 chr8:33679744 T/A ch.8.33884649F chr8:33765107 NA 0.57 7.4 0.41 1.84e-12 Body mass index; CESC cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg22875332 chr1:76189707 ACADM -0.54 -5.79 -0.34 1.94e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.01 9.85 0.52 1.05e-19 Platelet count; CESC trans rs1728785 1.000 rs8058145 chr16:68584090 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.48 0.42 1.11e-12 Ulcerative colitis; CESC cis rs1348850 0.513 rs6730406 chr2:178492722 C/T cg22681709 chr2:178499509 PDE11A -0.41 -5.69 -0.33 3.41e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7845219 0.544 rs6987400 chr8:95921295 T/C cg23172400 chr8:95962367 TP53INP1 -0.37 -6.78 -0.38 7.89e-11 Type 2 diabetes; CESC cis rs11792861 0.926 rs72607172 chr9:111876523 A/G cg05043794 chr9:111880884 C9orf5 -0.42 -6.94 -0.39 3.07e-11 Menarche (age at onset); CESC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg25767906 chr1:53392781 SCP2 0.43 5.99 0.35 6.77e-9 Monocyte count; CESC cis rs8067545 0.611 rs12603372 chr17:20181566 C/T cg13482628 chr17:19912719 NA 0.42 5.54 0.32 7.4e-8 Schizophrenia; CESC cis rs858239 0.670 rs6967526 chr7:23159241 C/A cg27449745 chr7:23145252 KLHL7 -0.48 -6.31 -0.36 1.16e-9 Cerebrospinal fluid biomarker levels; CESC cis rs9399401 0.601 rs9321870 chr6:142800758 A/T cg04461802 chr6:142623433 GPR126 0.41 6.24 0.36 1.72e-9 Chronic obstructive pulmonary disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18040997 chr19:47551898 TMEM160 0.48 6.26 0.36 1.54e-9 Systemic lupus erythematosus; CESC cis rs634534 0.561 rs613924 chr11:65769295 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.75 10.97 0.56 2.48e-23 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.09 11.08 0.56 1.09e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs13205180 0.550 rs4711997 chr6:51984771 C/A cg14179581 chr1:50881502 NA -0.28 -6.09 -0.35 4.05e-9 Diastolic blood pressure; CESC cis rs35110281 0.840 rs7276633 chr21:45078800 C/T cg04455712 chr21:45112962 RRP1B 0.39 5.9 0.34 1.08e-8 Mean corpuscular volume; CESC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg08704250 chr15:31115839 NA 0.64 8.95 0.48 6.48e-17 Huntington's disease progression; CESC cis rs7147624 0.882 rs7141367 chr14:65938641 C/T cg03016385 chr14:66212404 NA -0.49 -5.11 -0.3 6.05e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 5.52 0.32 8.07e-8 Osteoporosis; CESC cis rs17209837 0.607 rs45553044 chr7:87085613 A/G cg00919237 chr7:87102261 ABCB4 -0.51 -6.58 -0.37 2.45e-10 Gallbladder cancer; CESC cis rs12701220 0.948 rs12690826 chr7:1081618 A/G cg26769984 chr7:1090371 C7orf50 0.66 7.42 0.41 1.57e-12 Bronchopulmonary dysplasia; CESC cis rs3087591 0.960 rs9903754 chr17:29634468 G/A cg24425628 chr17:29625626 OMG;NF1 -0.41 -5.05 -0.3 8.18e-7 Hip circumference; CESC cis rs367943 0.901 rs171180 chr5:112817093 A/C cg12552261 chr5:112820674 MCC -0.62 -7.78 -0.43 1.58e-13 Type 2 diabetes; CESC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg14298792 chr15:30685198 CHRFAM7A -0.45 -5.39 -0.31 1.55e-7 Huntington's disease progression; CESC cis rs6540559 0.543 rs664097 chr1:210422179 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.54 6.11 0.35 3.53e-9 Cleft lip with or without cleft palate; CESC cis rs4730250 0.670 rs9641380 chr7:106868151 C/G cg02696742 chr7:106810147 HBP1 -0.53 -5.08 -0.3 7.18e-7 Osteoarthritis; CESC cis rs2228479 0.850 rs62052212 chr16:89981960 G/A cg14709524 chr16:89940631 TCF25 0.85 6.08 0.35 4.28e-9 Skin colour saturation; CESC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg19729930 chr2:74357872 NA 0.85 12.96 0.62 4.55e-30 Gestational age at birth (maternal effect); CESC cis rs9611565 0.694 rs5758324 chr22:41787950 G/T cg06481639 chr22:41940642 POLR3H -0.43 -5.12 -0.3 5.95e-7 Vitiligo; CESC cis rs7312933 0.670 rs2406568 chr12:42552297 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.25 0.36 1.64e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6089829 0.692 rs6122349 chr20:61664096 T/C cg03213289 chr20:61660250 NA 0.42 5.68 0.33 3.57e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06424138 chr8:102701376 NCALD 0.49 6.35 0.36 9.26e-10 Fibrinogen levels; CESC cis rs17376456 0.877 rs13173952 chr5:93307557 A/T cg25358565 chr5:93447407 FAM172A 1.08 10.73 0.55 1.54e-22 Diabetic retinopathy; CESC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg11644478 chr21:40555479 PSMG1 -0.8 -11.9 -0.59 1.9e-26 Cognitive function; CESC cis rs317689 0.718 rs315122 chr12:69771073 G/T cg14784868 chr12:69753453 YEATS4 0.65 7.63 0.42 4.24e-13 Response to diuretic therapy; CESC cis rs4237845 0.591 rs10431506 chr12:58311524 G/A cg02175503 chr12:58329896 NA 0.8 10.49 0.54 9.11e-22 Intelligence (multi-trait analysis); CESC trans rs747782 0.528 rs4370963 chr11:48433943 C/G cg15704280 chr7:45808275 SEPT13 0.68 6.21 0.36 2.09e-9 Intraocular pressure; CESC trans rs61931739 0.534 rs10844816 chr12:34248533 C/A cg26384229 chr12:38710491 ALG10B 0.64 9.16 0.49 1.47e-17 Morning vs. evening chronotype; CESC cis rs10751667 0.666 rs10902249 chr11:958566 C/T cg20946044 chr11:1010712 AP2A2 0.42 5.94 0.34 8.97e-9 Alzheimer's disease (late onset); CESC cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg23158103 chr7:148848205 ZNF398 -0.36 -5.35 -0.31 1.87e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs763014 0.931 rs3752568 chr16:628302 A/G cg07256732 chr16:621771 PIGQ -0.3 -5.13 -0.3 5.63e-7 Height; CESC cis rs4949454 0.542 rs10914457 chr1:32094261 A/C cg13919466 chr1:32135498 COL16A1 0.43 7.13 0.4 9.75e-12 Intelligence (multi-trait analysis); CESC cis rs12477438 0.765 rs6754843 chr2:99680485 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs3105593 1.000 rs3131585 chr15:50845796 C/G cg08437265 chr15:50716283 USP8 0.41 5.35 0.31 1.94e-7 QT interval; CESC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg11494091 chr17:61959527 GH2 -0.68 -11.19 -0.57 4.74e-24 Prudent dietary pattern; CESC cis rs12142240 0.698 rs72677599 chr1:46834251 G/A cg10495392 chr1:46806563 NSUN4 0.58 6.24 0.36 1.68e-9 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12898849 chr1:178511736 C1orf220 -0.46 -6.14 -0.35 3.04e-9 Fibrinogen levels; CESC cis rs9815354 0.812 rs73071304 chr3:41797504 G/C cg03022575 chr3:42003672 ULK4 0.72 6.35 0.36 9.1e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg18350739 chr11:68623251 NA -0.44 -6.44 -0.37 5.72e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg25072359 chr17:41440525 NA 0.48 7.1 0.4 1.15e-11 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04946948 chr11:71196653 NADSYN1 -0.67 -8.11 -0.45 1.87e-14 Gut microbiome composition (summer); CESC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg16680214 chr1:154839983 KCNN3 0.45 7.09 0.4 1.21e-11 Prostate cancer; CESC cis rs344364 0.518 rs1657129 chr16:1945826 G/A cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg18305652 chr10:134549665 INPP5A 0.48 6.75 0.38 9.22e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2637266 0.967 rs2579760 chr10:78321768 A/C cg18941641 chr10:78392320 NA 0.4 7.36 0.41 2.38e-12 Pulmonary function; CESC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.07 0.3 7.37e-7 Schizophrenia; CESC cis rs1729951 0.575 rs361243 chr3:136697786 C/T cg04103450 chr3:136751342 NA 0.4 5.35 0.31 1.94e-7 Neuroticism; CESC cis rs8038465 0.622 rs62004587 chr15:73859016 A/C cg15420318 chr15:73925796 NPTN 0.47 6.55 0.37 2.96e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1499972 0.887 rs6799997 chr3:117520297 A/C cg07612923 chr3:117604196 NA 0.72 6.36 0.36 8.93e-10 Schizophrenia; CESC cis rs62064224 0.530 rs8073708 chr17:30680493 T/C cg18200150 chr17:30822561 MYO1D 0.39 5.14 0.3 5.45e-7 Schizophrenia; CESC cis rs13040088 1.000 rs2295000 chr20:61536938 A/G cg23096297 chr20:61557774 DIDO1 -0.96 -10.72 -0.55 1.67e-22 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23411981 chr14:105940377 CRIP2 -0.45 -6.08 -0.35 4.24e-9 Gut microbiota (bacterial taxa); CESC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg06108461 chr20:60628389 TAF4 -0.89 -14.08 -0.65 5.56e-34 Body mass index; CESC cis rs10911232 0.507 rs10737239 chr1:183030170 A/C ch.1.3577855R chr1:183094577 LAMC1 0.87 13.57 0.64 3.18e-32 Hypertriglyceridemia; CESC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg12311346 chr5:56204834 C5orf35 -0.7 -8.58 -0.47 8.33e-16 Initial pursuit acceleration; CESC cis rs9467711 0.606 rs2073530 chr6:26375243 T/C cg14345882 chr6:26364793 BTN3A2 0.63 6.39 0.37 7.52e-10 Autism spectrum disorder or schizophrenia; CESC cis rs1728785 1.000 rs11075680 chr16:68565700 G/C cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs6032067 1.000 rs13041304 chr20:43811697 G/A cg10761708 chr20:43804764 PI3 0.54 6.5 0.37 3.97e-10 Blood protein levels; CESC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.38 5.15 0.3 5.18e-7 Lymphocyte counts; CESC cis rs9513593 0.901 rs7330165 chr13:99889427 C/T cg21788972 chr13:99853209 UBAC2 -0.59 -6.75 -0.38 9.46e-11 Psoriasis; CESC cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg21573476 chr21:45109991 RRP1B 0.41 5.9 0.34 1.09e-8 Mean corpuscular volume; CESC cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs10838687 0.800 rs10838686 chr11:47311367 G/T cg25783544 chr11:47291846 MADD 0.56 6.44 0.37 5.67e-10 Proinsulin levels; CESC cis rs9868809 0.772 rs9841602 chr3:48713570 A/G cg03060546 chr3:49711283 APEH -0.63 -5.6 -0.33 5.46e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.76 -10.28 -0.53 4.3e-21 Mean platelet volume; CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07148535 chr4:100010082 ADH5 0.61 6.57 0.37 2.68e-10 Gut microbiome composition (summer); CESC cis rs4417704 0.525 rs12694990 chr2:241883621 C/G cg05025159 chr2:241905733 NA 0.35 5.06 0.3 7.71e-7 Joint mobility (Beighton score); CESC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg18876405 chr7:65276391 NA 0.46 5.9 0.34 1.11e-8 Calcium levels; CESC cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg20503657 chr10:835505 NA 1.09 10.01 0.52 3.32e-20 Eosinophil percentage of granulocytes; CESC trans rs61931739 0.500 rs7977186 chr12:34431486 C/G cg26384229 chr12:38710491 ALG10B 0.69 10.37 0.54 2.3e-21 Morning vs. evening chronotype; CESC cis rs9916302 0.904 rs2338797 chr17:37548241 G/A cg00129232 chr17:37814104 STARD3 0.56 7.31 0.41 3.17e-12 Glomerular filtration rate (creatinine); CESC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg12463550 chr7:65579703 CRCP -0.45 -5.72 -0.33 2.86e-8 Aortic root size; CESC cis rs4253772 0.591 rs6008362 chr22:46652737 G/A cg24881330 chr22:46731750 TRMU 0.89 10.15 0.53 1.19e-20 LDL cholesterol;Cholesterol, total; CESC cis rs2228479 0.717 rs1007932 chr16:89838541 C/T cg14709524 chr16:89940631 TCF25 0.66 5.51 0.32 8.35e-8 Skin colour saturation; CESC cis rs1670533 1.000 rs10084888 chr4:1053814 G/T cg27284194 chr4:1044797 NA 0.46 5.86 0.34 1.35e-8 Recombination rate (females); CESC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg19717773 chr7:2847554 GNA12 -0.58 -7.89 -0.44 7.78e-14 Height; CESC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg13390004 chr1:15929781 NA 0.38 6.01 0.35 6.03e-9 Systolic blood pressure; CESC cis rs9905704 0.846 rs372648 chr17:56736785 A/C cg12560992 chr17:57184187 TRIM37 0.62 7.73 0.43 2.17e-13 Testicular germ cell tumor; CESC cis rs473651 0.837 rs563458 chr2:239345613 T/A cg18131467 chr2:239335373 ASB1 1.01 20.78 0.79 1.41e-57 Multiple system atrophy; CESC cis rs7223966 0.960 rs11659013 chr17:61869559 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.74 0.38 9.84e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg10845886 chr2:3471009 TTC15 -0.65 -9.01 -0.48 4.18e-17 Neurofibrillary tangles; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg26650007 chr19:14065157 DCAF15;PODNL1 0.38 6.1 0.35 3.8e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs589448 0.900 rs588493 chr12:69751986 G/A cg14784868 chr12:69753453 YEATS4 0.91 14.57 0.67 1.05e-35 Cerebrospinal fluid biomarker levels; CESC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Depression; CESC cis rs66887589 0.616 rs1052633 chr4:120215314 A/G cg09307838 chr4:120376055 NA 0.67 9.36 0.5 3.47e-18 Diastolic blood pressure; CESC cis rs17407555 0.520 rs4292327 chr4:9943700 G/A cg00071950 chr4:10020882 SLC2A9 -0.59 -6.33 -0.36 1.05e-9 Schizophrenia (age at onset); CESC trans rs35110281 0.811 rs9980185 chr21:45057905 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 6.82 0.39 6.32e-11 Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04250904 chr19:12623422 ZNF709 0.48 6.79 0.38 7.45e-11 Fibrinogen levels; CESC cis rs4253772 0.591 rs11704614 chr22:46691936 A/G cg24881330 chr22:46731750 TRMU 0.73 5.24 0.31 3.32e-7 LDL cholesterol;Cholesterol, total; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02621907 chr5:93954419 ANKRD32;C5orf36 0.46 5.99 0.35 6.65e-9 Gut microbiota (bacterial taxa); CESC trans rs722599 0.748 rs20578 chr14:75367807 C/T cg00095594 chr1:236228625 NID1 -0.4 -6.19 -0.36 2.31e-9 IgG glycosylation; CESC cis rs2120019 1.000 rs8033837 chr15:75353975 A/C cg17294928 chr15:75287854 SCAMP5 -0.65 -7.04 -0.4 1.67e-11 Blood trace element (Zn levels); CESC cis rs10751667 0.600 rs1128419 chr11:1010750 G/A cg06064525 chr11:970664 AP2A2 -0.33 -5.55 -0.32 7.1e-8 Alzheimer's disease (late onset); CESC cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9660992 0.710 rs1668873 chr1:205235990 G/A cg00857998 chr1:205179979 DSTYK 0.46 5.25 0.31 3.08e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg11663144 chr21:46675770 NA -0.62 -9.45 -0.5 1.84e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs72634258 0.945 rs6577459 chr1:8100173 G/T cg00042356 chr1:8021962 PARK7 0.76 6.78 0.38 7.86e-11 Inflammatory bowel disease; CESC cis rs3015497 0.603 rs3015450 chr14:51072713 C/T cg26011998 chr14:51135199 SAV1 -0.46 -5.22 -0.31 3.6e-7 Mean platelet volume; CESC cis rs4727027 0.704 rs4727031 chr7:148908305 T/C cg23583168 chr7:148888333 NA -0.88 -14.24 -0.66 1.49e-34 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs11098499 0.780 rs12504773 chr4:120562149 G/C cg09307838 chr4:120376055 NA 0.85 11.51 0.58 4.09e-25 Corneal astigmatism; CESC cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg06808227 chr14:105710500 BRF1 0.65 7.61 0.42 4.82e-13 Mean platelet volume;Platelet distribution width; CESC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg27572855 chr1:25598939 RHD 0.43 7.23 0.41 5.06e-12 Erythrocyte sedimentation rate; CESC cis rs1003719 0.715 rs2835657 chr21:38565064 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.18 -0.45 1.19e-14 Eye color traits; CESC cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9911578 0.900 rs4793593 chr17:56892699 C/G cg12560992 chr17:57184187 TRIM37 -0.91 -15.27 -0.68 3.41e-38 Intelligence (multi-trait analysis); CESC cis rs796364 0.616 rs2689765 chr2:200696352 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.56 5.37 0.31 1.74e-7 Schizophrenia; CESC cis rs1577917 1.000 rs12213740 chr6:86656733 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -5.61 -0.33 5.17e-8 Response to antipsychotic treatment; CESC cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg18225595 chr11:63971243 STIP1 0.68 9.54 0.51 9.82e-19 Platelet count; CESC cis rs2361718 0.521 rs2361724 chr17:78099114 G/A cg23534315 chr17:78082725 GAA 0.37 5.21 0.3 3.87e-7 Yeast infection; CESC cis rs9906944 0.933 rs35051752 chr17:47089908 G/A cg16584676 chr17:46985605 UBE2Z -0.45 -5.09 -0.3 6.8e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs9863 0.828 rs7311969 chr12:124470333 C/T cg17562584 chr12:124393655 DNAH10 -0.31 -5.28 -0.31 2.75e-7 White blood cell count; CESC cis rs9296736 1.000 rs9296736 chr6:53924697 A/G cg04374786 chr6:53939321 C6orf142 0.33 5.09 0.3 6.69e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs2727020 0.796 rs7131672 chr11:49274421 A/C cg15704280 chr7:45808275 SEPT13 0.78 10.0 0.52 3.38e-20 Coronary artery disease; CESC cis rs262150 0.851 rs2527224 chr7:158769198 G/A cg09640425 chr7:158790006 NA -0.35 -5.25 -0.31 3.16e-7 Facial morphology (factor 20); CESC cis rs17818399 1.000 rs17818399 chr2:46826026 A/C cg06386533 chr2:46925753 SOCS5 0.49 5.72 0.33 2.91e-8 Height; CESC cis rs1729951 0.575 rs10935213 chr3:136693459 A/G cg25687071 chr3:136751404 NA 0.4 5.3 0.31 2.47e-7 Neuroticism; CESC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.92 -0.52 6.14e-20 Developmental language disorder (linguistic errors); CESC cis rs12701220 0.842 rs10236293 chr7:1032637 G/A cg26769984 chr7:1090371 C7orf50 0.6 6.84 0.39 5.5e-11 Bronchopulmonary dysplasia; CESC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs68170813 0.570 rs7794915 chr7:106849393 C/T cg02696742 chr7:106810147 HBP1 -0.58 -5.19 -0.3 4.26e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12550816 chr19:47163979 DACT3 0.58 6.88 0.39 4.2e-11 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs3924498 chr6:146233338 A/T cg23711669 chr6:146136114 FBXO30 -0.94 -13.73 -0.64 9.31e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs12586317 0.547 rs77262907 chr14:35495734 C/G cg05294307 chr14:35346193 BAZ1A -0.51 -5.4 -0.31 1.49e-7 Psoriasis; CESC cis rs2191566 0.959 rs7255623 chr19:44510906 G/C cg20607764 chr19:44506953 ZNF230 -0.6 -7.8 -0.43 1.4e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs752092 1.000 rs11636578 chr15:101787969 T/C cg19997662 chr15:101784653 CHSY1 -0.57 -7.73 -0.43 2.24e-13 Corneal structure; CESC cis rs12079745 0.793 rs12067139 chr1:169254507 C/T cg09363564 chr1:169337483 NME7;BLZF1 -0.94 -6.2 -0.36 2.13e-9 QT interval; CESC cis rs2898681 0.519 rs73814886 chr4:53733251 C/T cg00791764 chr4:53727839 RASL11B 0.42 5.03 0.3 8.85e-7 Optic nerve measurement (cup area); CESC cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg12656391 chr1:43425156 SLC2A1 -0.57 -6.36 -0.36 8.67e-10 Monocyte count; CESC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg08736216 chr1:53307985 ZYG11A 0.4 6.73 0.38 1.07e-10 Monocyte count; CESC cis rs2197308 0.565 rs12809769 chr12:37909968 C/T cg26384229 chr12:38710491 ALG10B 0.75 11.12 0.56 8.21e-24 Morning vs. evening chronotype; CESC cis rs1707322 0.963 rs10789478 chr1:46350506 C/T cg05343316 chr1:45956843 TESK2 0.49 5.94 0.34 8.87e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9291683 0.554 rs7668175 chr4:10125782 T/C cg11266682 chr4:10021025 SLC2A9 -0.48 -8.58 -0.47 8.08e-16 Bone mineral density; CESC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg07701084 chr6:150067640 NUP43 0.45 6.27 0.36 1.42e-9 Lung cancer; CESC cis rs10779751 1.000 rs7524202 chr1:11297762 T/C cg08854313 chr1:11322531 MTOR 0.79 10.78 0.55 1.06e-22 Body mass index; CESC cis rs3820928 0.874 rs10183633 chr2:227887828 A/G cg11843606 chr2:227700838 RHBDD1 -0.45 -5.93 -0.34 9.66e-9 Pulmonary function; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19627653 chr12:133365649 GOLGA3 -0.45 -6.05 -0.35 4.97e-9 Systemic lupus erythematosus; CESC cis rs67311347 1.000 rs2168111 chr3:40395325 T/G cg09455208 chr3:40491958 NA 0.46 8.08 0.44 2.35e-14 Renal cell carcinoma; CESC cis rs854765 0.551 rs8070748 chr17:17859421 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs6674176 0.935 rs4314918 chr1:44377503 G/A cg12908607 chr1:44402522 ARTN -0.48 -6.67 -0.38 1.52e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7772486 0.597 rs9285508 chr6:146262697 G/T cg23711669 chr6:146136114 FBXO30 -0.87 -9.58 -0.51 7.49e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs4888262 0.545 rs4243108 chr16:74692453 A/G cg01733217 chr16:74700730 RFWD3 -0.91 -12.31 -0.6 7.71e-28 Testicular germ cell tumor; CESC trans rs9858542 1.000 rs4283605 chr3:49678651 A/G cg21659725 chr3:3221576 CRBN -0.53 -6.38 -0.36 7.75e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7666738 0.570 rs1869351 chr4:99077286 T/C cg17366294 chr4:99064904 C4orf37 0.45 6.03 0.35 5.39e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg22800045 chr5:56110881 MAP3K1 0.81 9.66 0.51 4.1e-19 Initial pursuit acceleration; CESC cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg11279151 chr3:101281821 RG9MTD1 -0.46 -5.12 -0.3 5.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2652822 0.525 rs1910094 chr15:63485527 G/C cg02713581 chr15:63449717 RPS27L 0.5 6.44 0.37 5.72e-10 Metabolic traits; CESC cis rs7927771 0.524 rs11039377 chr11:47789776 C/T cg20307385 chr11:47447363 PSMC3 0.62 8.69 0.47 3.96e-16 Subjective well-being; CESC cis rs6748734 1.000 rs4675863 chr2:241830763 A/T cg04034577 chr2:241836375 C2orf54 -0.48 -8.29 -0.45 5.55e-15 Urinary metabolites; CESC cis rs7208859 0.673 rs11649765 chr17:29233888 T/A cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs55883249 0.957 rs17453675 chr2:9754407 A/G cg23886495 chr2:9695866 ADAM17 0.65 5.89 0.34 1.19e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs7923609 0.967 rs7896783 chr10:65162153 G/A cg01631684 chr10:65280961 REEP3 -0.44 -5.48 -0.32 9.84e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs4699052 0.662 rs6848593 chr4:104250113 G/T cg16532752 chr4:104119610 CENPE -0.41 -5.85 -0.34 1.44e-8 Testicular germ cell tumor; CESC cis rs1322639 0.575 rs9294966 chr6:169565318 G/T cg03254818 chr6:169586852 NA 0.53 5.78 0.33 2.09e-8 Pulse pressure; CESC cis rs11098499 0.954 rs35091806 chr4:120325529 G/A cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg22029157 chr1:209979665 IRF6 -0.48 -7.75 -0.43 2.03e-13 Monobrow; CESC trans rs9325144 0.555 rs4882279 chr12:38688918 C/A cg23762105 chr12:34175262 ALG10 -0.46 -6.15 -0.35 2.77e-9 Morning vs. evening chronotype; CESC cis rs72945132 0.825 rs7941965 chr11:70213182 T/C cg14191688 chr11:70257035 CTTN 0.43 5.38 0.31 1.62e-7 Coronary artery disease; CESC cis rs6580649 0.941 rs60681522 chr12:48464195 T/C cg24011408 chr12:48396354 COL2A1 -0.41 -5.27 -0.31 2.86e-7 Lung cancer; CESC cis rs9584850 0.609 rs17574495 chr13:99155113 C/T cg20750642 chr13:99100586 FARP1 -0.4 -5.58 -0.32 5.99e-8 Neuroticism; CESC cis rs9486715 1.000 rs9486725 chr6:97061159 C/T cg06623918 chr6:96969491 KIAA0776 -0.95 -14.42 -0.66 3.43e-35 Headache; CESC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg19770292 chr5:1868693 NA 0.31 5.19 0.3 4.26e-7 Cardiovascular disease risk factors; CESC cis rs1595825 0.891 rs80178661 chr2:198582442 A/G cg00982548 chr2:198649783 BOLL -0.49 -5.28 -0.31 2.69e-7 Ulcerative colitis; CESC cis rs7607369 0.648 rs17470271 chr2:219651995 A/T cg02176678 chr2:219576539 TTLL4 0.51 9.21 0.49 1.06e-17 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs753307 0.676 rs753308 chr19:49518575 C/T cg20610492 chr19:49520450 LHB 0.36 5.87 0.34 1.27e-8 Blood protein levels; CESC cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.48 7.83 0.43 1.21e-13 Hemoglobin concentration; CESC cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg15541040 chr2:3486749 NA -0.43 -5.38 -0.31 1.64e-7 Neurofibrillary tangles; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26790879 chr11:58939953 DTX4 0.62 7.06 0.4 1.47e-11 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13762887 chr9:131517731 ZER1 0.45 6.59 0.38 2.4e-10 Fibrinogen levels; CESC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.7 0.38 1.22e-10 Bipolar disorder; CESC cis rs1595825 0.891 rs73054819 chr2:198625744 G/T cg00982548 chr2:198649783 BOLL -0.47 -5.08 -0.3 7.12e-7 Ulcerative colitis; CESC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg23131131 chr22:24373011 LOC391322 -0.68 -9.31 -0.5 5.2e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 10.34 0.54 2.91e-21 Platelet count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05598539 chr7:128695331 TNPO3;LOC286016 -0.49 -7.04 -0.4 1.68e-11 Gambling; CESC cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg06212747 chr3:49208901 KLHDC8B 0.67 9.18 0.49 1.28e-17 Parkinson's disease; CESC cis rs2933343 0.700 rs1680779 chr3:128614770 G/A cg24203234 chr3:128598194 ACAD9 0.42 5.55 0.32 6.75e-8 IgG glycosylation; CESC cis rs2425143 1.000 rs6058304 chr20:34299851 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.14 0.3 5.33e-7 Blood protein levels; CESC cis rs11122272 0.735 rs2749708 chr1:231529610 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg00745463 chr17:30367425 LRRC37B 0.58 5.72 0.33 2.86e-8 Hip circumference adjusted for BMI; CESC cis rs6570726 0.935 rs366621 chr6:145861275 A/G cg23711669 chr6:146136114 FBXO30 0.79 11.57 0.58 2.41e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs8060686 0.544 rs1124993 chr16:68114626 T/C cg26727032 chr16:67993705 SLC12A4 -0.56 -6.61 -0.38 2.06e-10 HDL cholesterol;Metabolic syndrome; CESC trans rs10506458 1.000 rs1495013 chr12:63428188 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -17.74 -0.74 6.16e-47 Hemostatic factors and hematological phenotypes; CESC cis rs1865721 0.728 rs8087297 chr18:73136221 T/A cg26385618 chr18:73139727 C18orf62 -0.49 -7.96 -0.44 5.22e-14 Intelligence; CESC cis rs12477438 0.520 rs6542866 chr2:99764592 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.4 0.64 1.33e-31 Chronic sinus infection; CESC cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg01579765 chr21:45077557 HSF2BP -0.56 -9.34 -0.5 4.18e-18 Mean corpuscular volume; CESC cis rs477692 0.905 rs509041 chr10:131424948 A/G cg05714579 chr10:131428358 MGMT 0.58 8.4 0.46 2.66e-15 Response to temozolomide; CESC cis rs12541635 0.739 rs1896915 chr8:107083520 G/T cg10147462 chr8:107024639 NA 0.36 5.06 0.3 7.86e-7 Age of smoking initiation; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08647641 chr7:91763896 CYP51A1 -0.46 -6.18 -0.35 2.47e-9 Ulcerative colitis; CESC cis rs4974559 0.947 rs28418481 chr4:1330975 C/G cg02980000 chr4:1222292 CTBP1 0.64 7.58 0.42 5.76e-13 Systolic blood pressure; CESC trans rs60843830 0.964 rs7584915 chr2:264227 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 8.3 0.45 5.3e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg17949981 chr6:28129498 ZNF389 0.43 5.58 0.32 5.97e-8 Depression; CESC cis rs3806843 0.733 rs801181 chr5:140092814 C/T cg26395211 chr5:140044315 WDR55 0.45 6.04 0.35 5.08e-9 Depressive symptoms (multi-trait analysis); CESC cis rs9911578 0.839 rs1871751 chr17:57190368 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.87 -0.39 4.59e-11 Intelligence (multi-trait analysis); CESC cis rs7223966 1.000 rs9895920 chr17:61852719 T/C cg11494091 chr17:61959527 GH2 0.38 5.32 0.31 2.26e-7 Hip circumference adjusted for BMI;Body mass index; CESC trans rs526821 0.595 rs517627 chr11:55356489 C/T cg15704280 chr7:45808275 SEPT13 -0.52 -6.55 -0.37 2.99e-10 Pediatric bone mineral density (spine); CESC cis rs3126085 1.000 rs3126092 chr1:152307955 T/A cg03465714 chr1:152285911 FLG 0.43 5.22 0.31 3.62e-7 Atopic dermatitis; CESC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg03452623 chr4:187889614 NA -0.89 -16.23 -0.71 1.34e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs863345 0.625 rs4609418 chr1:158464728 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.9 -0.39 3.83e-11 Pneumococcal bacteremia; CESC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg14403583 chr14:105418241 AHNAK2 0.59 8.24 0.45 7.91e-15 Rheumatoid arthritis; CESC cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg02221750 chr19:17393354 ANKLE1 -0.54 -6.5 -0.37 4.05e-10 Systemic lupus erythematosus; CESC cis rs17376456 0.597 rs10064158 chr5:93095186 C/T cg25358565 chr5:93447407 FAM172A 0.67 7.16 0.4 7.97e-12 Diabetic retinopathy; CESC cis rs9611565 0.729 rs132902 chr22:41797758 A/G cg06634786 chr22:41940651 POLR3H -0.62 -6.85 -0.39 5.17e-11 Vitiligo; CESC cis rs7923609 0.967 rs10761766 chr10:65190327 G/A cg01631684 chr10:65280961 REEP3 -0.44 -5.48 -0.32 9.84e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs9863706 0.619 rs2118592 chr3:72504654 A/G cg22685502 chr3:72496851 RYBP -0.25 -5.28 -0.31 2.69e-7 Height; CESC cis rs7085104 0.660 rs7902804 chr10:104585405 A/T cg04362960 chr10:104952993 NT5C2 0.47 6.17 0.35 2.48e-9 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs9457247 0.905 rs453184 chr6:167387404 A/C cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs7762018 0.891 rs73242950 chr6:170144737 C/T cg05834625 chr6:170176447 C6orf70 0.65 7.37 0.41 2.19e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7772486 0.686 rs9376956 chr6:145949844 T/C cg05347473 chr6:146136440 FBXO30 0.53 6.91 0.39 3.53e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.23 0.31 3.44e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19871361 chr10:11505280 USP6NL -0.53 -6.08 -0.35 4.25e-9 Gut microbiome composition (summer); CESC cis rs11792861 0.926 rs75472294 chr9:111804239 G/A cg13535736 chr9:111863775 C9orf5 -0.5 -6.6 -0.38 2.29e-10 Menarche (age at onset); CESC cis rs4450798 0.649 rs4073434 chr3:13787501 C/T cg23332027 chr3:13681764 NA 0.38 5.14 0.3 5.41e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs3008870 1.000 rs58680688 chr1:67443751 C/G cg02640540 chr1:67518911 SLC35D1 -0.52 -5.66 -0.33 3.9e-8 Lymphocyte percentage of white cells; CESC cis rs11098499 0.779 rs80242894 chr4:120375752 G/A cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.19e-8 Corneal astigmatism; CESC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.93 0.39 3.13e-11 Bipolar disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22295628 chr17:1733433 RPA1;SMYD4 -0.48 -6.15 -0.35 2.9e-9 Ulcerative colitis; CESC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg07677032 chr17:61819896 STRADA 0.46 6.08 0.35 4.17e-9 Prudent dietary pattern; CESC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg12412775 chr1:25698385 RHCE 0.28 5.19 0.3 4.26e-7 Erythrocyte sedimentation rate; CESC cis rs477692 0.935 rs554458 chr10:131427372 A/G cg05714579 chr10:131428358 MGMT 0.6 8.83 0.48 1.43e-16 Response to temozolomide; CESC cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg24296786 chr1:45957014 TESK2 0.68 9.37 0.5 3.33e-18 High light scatter reticulocyte count; CESC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.46 -0.32 1.08e-7 Aortic root size; CESC cis rs2115630 1.000 rs11854291 chr15:85363708 T/C cg12501888 chr15:85177176 SCAND2 -0.4 -5.3 -0.31 2.49e-7 P wave terminal force; CESC cis rs7246657 0.943 rs713256 chr19:37865365 C/T cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs9488822 0.636 rs12524932 chr6:116330266 G/A cg26893134 chr6:116381904 FRK 0.25 6.0 0.35 6.32e-9 Cholesterol, total;LDL cholesterol; CESC cis rs11098499 0.954 rs7656252 chr4:120404268 T/C cg09307838 chr4:120376055 NA 0.93 13.07 0.63 1.78e-30 Corneal astigmatism; CESC cis rs9611565 0.592 rs5996039 chr22:41981957 A/G cg06634786 chr22:41940651 POLR3H -0.57 -6.28 -0.36 1.35e-9 Vitiligo; CESC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg17143192 chr8:8559678 CLDN23 -0.79 -9.63 -0.51 5.02e-19 Obesity-related traits; CESC cis rs7605827 0.930 rs13398393 chr2:15602804 T/G cg19274914 chr2:15703543 NA 0.37 6.61 0.38 2.16e-10 Educational attainment (years of education); CESC cis rs2120019 0.938 rs8033925 chr15:75311959 A/G cg17294928 chr15:75287854 SCAMP5 -0.73 -8.69 -0.47 3.87e-16 Blood trace element (Zn levels); CESC cis rs1912483 0.505 rs3760372 chr17:45380002 T/C cg08085267 chr17:45401833 C17orf57 -0.63 -7.47 -0.42 1.17e-12 Coronary artery disease; CESC cis rs1808579 0.904 rs1788761 chr18:21133084 A/G cg14672496 chr18:21087552 C18orf8 0.41 5.92 0.34 1e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg00684032 chr4:1343700 KIAA1530 0.4 5.56 0.32 6.51e-8 Obesity-related traits; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg01165297 chr16:475440 RAB11FIP3 -0.51 -6.17 -0.35 2.61e-9 Gut microbiota (bacterial taxa); CESC cis rs12079745 0.793 rs12561922 chr1:169265794 G/A cg09363564 chr1:169337483 NME7;BLZF1 -1.02 -6.24 -0.36 1.7e-9 QT interval; CESC cis rs2439831 0.681 rs2278859 chr15:43632960 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.85 12.6 0.61 7.52e-29 Lung cancer in ever smokers; CESC cis rs7927592 0.912 rs55767696 chr11:68375120 C/G cg20283391 chr11:68216788 NA -0.47 -5.76 -0.33 2.35e-8 Total body bone mineral density; CESC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg05863683 chr7:1912471 MAD1L1 0.42 6.24 0.36 1.69e-9 Bipolar disorder and schizophrenia; CESC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg05617483 chr15:76483344 C15orf27 0.39 5.16 0.3 4.9e-7 Blood metabolite levels; CESC cis rs763121 0.853 rs1056610 chr22:39080078 C/T cg14440974 chr22:39074834 NA 0.36 5.16 0.3 4.76e-7 Menopause (age at onset); CESC cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg20307385 chr11:47447363 PSMC3 0.63 7.92 0.44 6.71e-14 Subjective well-being; CESC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg23048001 chr7:2026167 MAD1L1 0.46 5.93 0.34 9.41e-9 Bipolar disorder and schizophrenia; CESC cis rs60733400 0.667 rs4385650 chr1:2499898 G/A cg18854424 chr1:2615690 NA 0.28 5.4 0.31 1.5e-7 Multiple sclerosis; CESC cis rs911555 0.723 rs4906320 chr14:103876925 T/C cg12935359 chr14:103987150 CKB 0.6 8.75 0.47 2.59e-16 Intelligence (multi-trait analysis); CESC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg08684580 chr7:98029266 BAIAP2L1 0.35 5.77 0.33 2.19e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg05347473 chr6:146136440 FBXO30 -0.56 -7.15 -0.4 8.5e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg18225595 chr11:63971243 STIP1 0.51 5.13 0.3 5.58e-7 Mean platelet volume; CESC cis rs2769264 0.546 rs12071705 chr1:151430504 G/C cg18801370 chr1:151430492 POGZ 0.84 10.7 0.55 1.86e-22 Blood trace element (Cu levels); CESC cis rs2050392 0.517 rs593400 chr10:30762088 A/G cg25182066 chr10:30743637 MAP3K8 0.5 7.22 0.41 5.41e-12 Inflammatory bowel disease; CESC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.12e-20 Prudent dietary pattern; CESC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg24399712 chr22:39784796 NA -0.8 -10.59 -0.55 4.24e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs2228479 0.850 rs62052212 chr16:89981960 G/A cg06558623 chr16:89946397 TCF25 1.14 8.8 0.48 1.83e-16 Skin colour saturation; CESC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg16278512 chr7:12443529 VWDE -0.5 -5.08 -0.3 7.3e-7 Coronary artery disease; CESC cis rs10028773 0.700 rs35653026 chr4:120248378 A/G cg09307838 chr4:120376055 NA 0.74 9.42 0.5 2.28e-18 Educational attainment; CESC cis rs9611565 0.802 rs132916 chr22:41806768 C/G cg03806693 chr22:41940476 POLR3H 0.77 9.34 0.5 3.97e-18 Vitiligo; CESC trans rs7945705 0.869 rs7925728 chr11:9013002 A/G cg07894846 chr19:1981143 CSNK1G2 0.39 6.11 0.35 3.61e-9 Hemoglobin concentration; CESC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg20607287 chr7:12443886 VWDE -0.71 -8.7 -0.47 3.54e-16 Coronary artery disease; CESC cis rs12500824 0.564 rs7660542 chr4:77234758 A/C cg20311846 chr4:77356250 SHROOM3 -0.38 -6.99 -0.39 2.2e-11 Coronary artery disease; CESC cis rs3820928 0.605 rs4675124 chr2:227802354 G/A cg05526886 chr2:227700861 RHBDD1 -0.53 -7.21 -0.41 5.72e-12 Pulmonary function; CESC trans rs629535 0.748 rs58675625 chr8:70034924 T/C cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs11779988 0.598 rs13255037 chr8:17911046 A/G cg18067069 chr8:17937731 ASAH1 -0.4 -5.27 -0.31 2.84e-7 Breast cancer; CESC cis rs9916302 0.861 rs3889368 chr17:37683231 C/T cg00129232 chr17:37814104 STARD3 -0.59 -7.77 -0.43 1.71e-13 Glomerular filtration rate (creatinine); CESC cis rs910316 0.737 rs175499 chr14:75535927 G/A cg11812906 chr14:75593930 NEK9 -0.84 -13.56 -0.64 3.55e-32 Height; CESC cis rs6968419 0.755 rs1141470 chr7:115898442 G/C cg02561103 chr7:115862891 TES -0.41 -5.42 -0.32 1.37e-7 Intraocular pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04370476 chr3:49761188 GMPPB -0.46 -6.4 -0.37 7.17e-10 Fibrinogen levels; CESC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg19046167 chr17:80928561 B3GNTL1 0.48 5.72 0.33 2.84e-8 Glycated hemoglobin levels; CESC cis rs7582720 1.000 rs72932590 chr2:203884308 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.71 9.83 0.52 1.19e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12344600 chr6:89769123 NA 0.43 6.0 0.35 6.41e-9 Fibrinogen levels; CESC cis rs11098499 0.909 rs17046118 chr4:120387496 T/G cg24375607 chr4:120327624 NA 0.44 5.48 0.32 9.91e-8 Corneal astigmatism; CESC cis rs2425143 1.000 rs2295356 chr20:34252856 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.14 0.3 5.43e-7 Blood protein levels; CESC cis rs6594499 0.872 rs10045255 chr5:110438357 C/T cg04022379 chr5:110408740 TSLP -0.33 -6.02 -0.35 5.81e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg24399712 chr22:39784796 NA -0.83 -10.24 -0.53 6.16e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs12971120 1.000 rs2278161 chr18:72176083 T/C cg25817165 chr18:72167213 CNDP2 -0.63 -7.9 -0.44 7.44e-14 Refractive error; CESC cis rs7223966 1.000 rs11657306 chr17:61704822 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.2 0.4 6.24e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1570884 0.516 rs9535268 chr13:50175478 C/A cg03651054 chr13:50194643 NA 0.31 5.1 0.3 6.6e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg02788857 chr8:22132959 PIWIL2 0.31 5.49 0.32 9.44e-8 Hypertriglyceridemia; CESC cis rs1421811 0.532 rs72740626 chr5:32692220 G/C cg16267343 chr5:32710456 NPR3 0.56 6.13 0.35 3.24e-9 Blood pressure; CESC cis rs8072100 0.738 rs9900123 chr17:45549055 T/C cg25173405 chr17:45401733 C17orf57 -0.45 -5.76 -0.33 2.38e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2014572 0.967 rs7259978 chr19:57756129 C/T cg24459738 chr19:57751996 ZNF805 -0.54 -7.74 -0.43 2.08e-13 Hyperactive-impulsive symptoms; CESC cis rs6831352 0.918 rs29001194 chr4:100054844 A/G cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs3892630 0.878 rs114224536 chr19:33211232 A/G cg13157960 chr19:33183277 NUDT19 0.55 5.06 0.3 7.79e-7 Red blood cell traits; CESC cis rs853679 0.769 rs7752608 chr6:28301195 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.78 6.51 0.37 3.69e-10 Depression; CESC cis rs7666738 0.546 rs10007424 chr4:98885450 C/T cg05340658 chr4:99064831 C4orf37 0.57 7.14 0.4 9.23e-12 Colonoscopy-negative controls vs population controls; CESC cis rs2880765 0.835 rs4526974 chr15:86024284 C/T cg10818794 chr15:86012489 AKAP13 -0.33 -5.12 -0.3 5.89e-7 Coronary artery disease; CESC cis rs11098499 0.863 rs10004484 chr4:120442428 C/T cg24375607 chr4:120327624 NA 0.42 5.06 0.3 7.67e-7 Corneal astigmatism; CESC cis rs6546537 0.550 rs4852272 chr2:69776730 C/T cg10773587 chr2:69614142 GFPT1 -0.51 -6.67 -0.38 1.48e-10 Serum thyroid-stimulating hormone levels; CESC trans rs10411161 0.702 rs7250193 chr19:52385520 C/T cg22319618 chr22:45562946 NUP50 0.7 7.14 0.4 8.99e-12 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06751603 chr19:11152063 SMARCA4 -0.62 -6.68 -0.38 1.44e-10 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09319706 chr4:75024153 MTHFD2L -0.51 -6.47 -0.37 4.79e-10 Ulcerative colitis; CESC cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.1 0.3 6.39e-7 Personality dimensions; CESC cis rs11677416 1.000 rs1878321 chr2:113544434 A/G cg27083787 chr2:113543245 IL1A 0.42 5.28 0.31 2.72e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs3749237 0.595 rs6784820 chr3:49450864 C/T cg02487422 chr3:49467188 NICN1 -0.55 -8.01 -0.44 3.62e-14 Resting heart rate; CESC cis rs1152591 0.543 rs1152590 chr14:64681193 C/T cg21174375 chr14:64681225 SYNE2 0.58 8.47 0.46 1.7e-15 Atrial fibrillation; CESC cis rs35110281 0.633 rs4819292 chr21:45125223 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -9.12 -0.49 1.93e-17 Mean corpuscular volume; CESC cis rs9400271 0.632 rs9386784 chr6:109591208 C/A cg01475377 chr6:109611718 NA -0.45 -7.02 -0.4 1.9e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.63 0.38 1.83e-10 Bipolar disorder; CESC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs62064224 0.902 rs35830939 chr17:30627564 A/C cg25809561 chr17:30822961 MYO1D 0.42 5.54 0.32 7.26e-8 Schizophrenia; CESC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.74 10.23 0.53 6.5e-21 Prudent dietary pattern; CESC cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg24308560 chr3:49941425 MST1R -0.64 -9.19 -0.49 1.17e-17 Intelligence (multi-trait analysis); CESC cis rs1957429 0.520 rs7144515 chr14:65333725 G/A cg23373153 chr14:65346875 NA -0.76 -5.81 -0.34 1.77e-8 Pediatric areal bone mineral density (radius); CESC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs950776 0.518 rs12903129 chr15:78819606 C/T cg06917634 chr15:78832804 PSMA4 0.79 12.0 0.59 9.02e-27 Sudden cardiac arrest; CESC cis rs116095464 0.558 rs6869925 chr5:264036 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.86e-15 Breast cancer; CESC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg03647317 chr4:187891568 NA -0.44 -6.92 -0.39 3.31e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg04518342 chr5:131593106 PDLIM4 0.39 5.8 0.34 1.86e-8 Breast cancer; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg21370966 chr3:149771534 NA 0.4 6.29 0.36 1.32e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7589728 0.858 rs1914734 chr2:88529509 T/C cg07952391 chr2:88470173 THNSL2 0.44 5.44 0.32 1.22e-7 Plasma clusterin levels; CESC cis rs9318086 0.578 rs2077709 chr13:24476073 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.44 -6.34 -0.36 9.71e-10 Myopia (pathological); CESC cis rs13102973 0.965 rs4864244 chr4:135866959 A/G cg14419869 chr4:135874104 NA 0.41 6.52 0.37 3.45e-10 Subjective well-being; CESC cis rs67478160 0.619 rs8018062 chr14:104281954 C/T cg08213375 chr14:104286397 PPP1R13B 0.54 10.7 0.55 1.97e-22 Schizophrenia; CESC cis rs644799 1.000 rs2508289 chr11:95624669 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.6 7.36 0.41 2.31e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg08968635 chr6:28129556 ZNF389 0.4 5.21 0.3 3.88e-7 Depression; CESC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg18876405 chr7:65276391 NA -0.53 -6.89 -0.39 3.98e-11 Aortic root size; CESC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg23161317 chr6:28129485 ZNF389 0.49 6.17 0.35 2.51e-9 Parkinson's disease; CESC cis rs4243830 0.850 rs1010584 chr1:6579843 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.76 -8.23 -0.45 8.77e-15 Body mass index; CESC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg18357526 chr6:26021779 HIST1H4A 0.56 7.47 0.42 1.18e-12 Intelligence (multi-trait analysis); CESC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg04155289 chr7:94953770 PON1 -0.51 -7.04 -0.4 1.61e-11 Paraoxonase activity; CESC cis rs1707322 0.789 rs10789473 chr1:46248131 C/T cg05343316 chr1:45956843 TESK2 0.47 5.73 0.33 2.75e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.31 0.76 1.74e-52 Height; CESC cis rs8141529 0.764 rs5762854 chr22:29246278 T/C cg15103426 chr22:29168792 CCDC117 0.7 9.78 0.52 1.7e-19 Lymphocyte counts; CESC cis rs11583043 1.000 rs12567858 chr1:101517688 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 5.63 0.33 4.64e-8 Ulcerative colitis;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07334509 chr8:74361129 STAU2 -0.59 -6.9 -0.39 3.92e-11 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg04369109 chr6:150039330 LATS1 -0.43 -5.96 -0.34 7.91e-9 Lung cancer; CESC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg06634786 chr22:41940651 POLR3H 0.71 6.94 0.39 3.02e-11 Vitiligo; CESC cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.86 7.32 0.41 2.88e-12 Initial pursuit acceleration; CESC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg15782153 chr7:917662 C7orf20 -0.49 -5.41 -0.32 1.4e-7 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06191580 chr17:35870477 DUSP14 -0.54 -6.82 -0.39 6.04e-11 Gut microbiome composition (summer); CESC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg08736216 chr1:53307985 ZYG11A -0.43 -7.08 -0.4 1.29e-11 Monocyte count; CESC trans rs4714888 1.000 rs3777562 chr6:45895815 C/T cg22014887 chr4:2749539 TNIP2 0.84 6.09 0.35 3.95e-9 Age-related macular degeneration; CESC trans rs9325144 0.555 rs7968322 chr12:38792348 T/C cg10679878 chr6:156759499 NA -0.33 -6.0 -0.35 6.32e-9 Morning vs. evening chronotype; CESC cis rs7937682 0.663 rs35581942 chr11:111756286 C/T cg22437258 chr11:111473054 SIK2 -0.5 -5.53 -0.32 7.6e-8 Primary sclerosing cholangitis; CESC trans rs60380162 0.963 rs55838834 chr1:87727640 G/T cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.03 -0.35 5.48e-9 Loneliness (linear analysis); CESC cis rs8027181 0.839 rs4777532 chr15:73041767 A/G cg25632853 chr15:73088954 NA 0.31 5.52 0.32 8.02e-8 Triglyceride levels; CESC cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg00825309 chr19:58991885 ZNF446 -0.54 -7.89 -0.44 8.09e-14 Uric acid clearance; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01911186 chr12:12765398 CREBL2 -0.44 -6.41 -0.37 6.8e-10 Gambling; CESC cis rs9291683 0.588 rs3756237 chr4:10013378 G/A cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.5e-12 Bone mineral density; CESC cis rs3747547 0.685 rs11791354 chr9:38125173 G/C cg13774184 chr9:37916125 SHB -0.63 -5.19 -0.3 4.17e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs3942852 0.774 rs10838814 chr11:48187178 G/A cg15704280 chr7:45808275 SEPT13 -0.73 -8.25 -0.45 7.61e-15 Acute lymphoblastic leukemia (childhood); CESC cis rs5769765 0.740 rs2103932 chr22:50272515 A/G cg02269571 chr22:50332266 NA 0.44 5.98 0.35 7.02e-9 Schizophrenia; CESC cis rs9911578 1.000 rs9911578 chr17:56953147 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.16 0.3 4.87e-7 Intelligence (multi-trait analysis); CESC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC cis rs13064411 0.696 rs13066742 chr3:113208423 T/C cg18753928 chr3:113234510 CCDC52 -0.5 -5.9 -0.34 1.11e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25336731 chr2:70520884 SNRPG 0.57 6.74 0.38 1.01e-10 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.07 0.35 4.37e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12530845 1.000 rs4291212 chr7:135335465 C/T cg23117316 chr7:135346802 PL-5283 -0.41 -5.21 -0.31 3.72e-7 Red blood cell traits; CESC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg00310523 chr12:86230176 RASSF9 0.38 5.98 0.34 7.37e-9 Major depressive disorder; CESC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs6424115 0.800 rs4649123 chr1:24197696 A/G cg10978503 chr1:24200527 CNR2 0.31 6.21 0.36 2e-9 Immature fraction of reticulocytes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg00974835 chr14:74960278 NPC2;ISCA2 0.49 6.52 0.37 3.62e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs763121 0.853 rs5757213 chr22:39053888 C/T cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.54e-7 Menopause (age at onset); CESC cis rs8017423 0.647 rs12883844 chr14:90820519 T/C cg14092571 chr14:90743983 NA 0.43 6.55 0.37 2.91e-10 Mortality in heart failure; CESC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 10.14 0.53 1.22e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4692589 1.000 rs7688417 chr4:170938732 C/T cg19918862 chr4:170955249 NA 0.36 5.5 0.32 8.93e-8 Anxiety disorder; CESC cis rs881375 0.678 rs4836834 chr9:123665901 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.63 0.42 4.26e-13 Rheumatoid arthritis; CESC cis rs34779708 0.931 rs35126129 chr10:35452141 G/A cg03585969 chr10:35415529 CREM 0.77 10.27 0.53 4.68e-21 Inflammatory bowel disease;Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09377882 chr17:43139021 NMT1;DCAKD 0.43 6.04 0.35 5.12e-9 Fibrinogen levels; CESC cis rs11098499 0.954 rs10006877 chr4:120242793 C/T cg24375607 chr4:120327624 NA 0.46 5.6 0.33 5.39e-8 Corneal astigmatism; CESC trans rs8073060 0.544 rs225249 chr17:33942540 T/C cg19694781 chr19:47549865 TMEM160 -0.71 -6.99 -0.39 2.2e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs1707322 1.000 rs3922886 chr1:46473902 A/T cg05343316 chr1:45956843 TESK2 0.44 5.35 0.31 1.9e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3812762 0.871 rs2173999 chr11:8778077 G/A cg03980550 chr11:8754370 ST5 0.37 5.32 0.31 2.22e-7 Hypospadias; CESC cis rs7208859 0.623 rs11651858 chr17:29170718 A/G cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg07677032 chr17:61819896 STRADA 0.44 5.81 0.34 1.81e-8 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27254601 chr16:29817104 MAZ -0.56 -6.4 -0.37 7.14e-10 Gut microbiome composition (summer); CESC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg24675658 chr1:53192096 ZYG11B 0.54 6.84 0.39 5.57e-11 Monocyte count; CESC cis rs10789491 1.000 rs12794 chr1:47141718 T/C cg15501359 chr1:47185051 KIAA0494 0.8 8.63 0.47 5.59e-16 Response to hepatitis C treatment; CESC cis rs9640161 0.789 rs34728606 chr7:150054694 G/A cg17279839 chr7:150038598 RARRES2 0.49 5.78 0.33 2.11e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs17253792 0.822 rs79291233 chr14:56065302 G/C cg01858014 chr14:56050164 KTN1 -0.96 -7.13 -0.4 9.72e-12 Putamen volume; CESC cis rs929354 0.772 rs1182448 chr7:157021415 G/A cg05182265 chr7:156933206 UBE3C 0.52 7.62 0.42 4.53e-13 Body mass index; CESC cis rs1499972 1.000 rs1499972 chr3:117719538 A/C cg07612923 chr3:117604196 NA -0.77 -5.71 -0.33 3.06e-8 Schizophrenia; CESC cis rs2637266 0.967 rs12254242 chr10:78352934 T/C cg18941641 chr10:78392320 NA 0.41 7.55 0.42 7.02e-13 Pulmonary function; CESC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg20243544 chr17:37824526 PNMT 0.5 6.25 0.36 1.64e-9 Glomerular filtration rate (creatinine); CESC cis rs35146811 0.586 rs6946168 chr7:99598286 C/T cg22906224 chr7:99728672 NA 0.44 5.19 0.3 4.24e-7 Coronary artery disease; CESC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.56 7.53 0.42 8.02e-13 Lymphocyte counts; CESC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg25036284 chr2:26402008 FAM59B -0.74 -8.4 -0.46 2.72e-15 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02884346 chr4:6271501 WFS1 0.65 7.83 0.43 1.16e-13 Gut microbiome composition (summer); CESC cis rs2346177 0.542 rs1900591 chr2:46697968 C/T cg02822958 chr2:46747628 ATP6V1E2 0.43 5.34 0.31 2e-7 HDL cholesterol; CESC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.93 0.44 6.13e-14 Electroencephalogram traits; CESC cis rs6456156 0.806 rs11967165 chr6:167529936 T/C cg07741184 chr6:167504864 NA -0.31 -5.12 -0.3 5.75e-7 Primary biliary cholangitis; CESC cis rs17401966 0.931 rs11121545 chr1:10411211 A/G cg15208524 chr1:10270712 KIF1B 0.4 5.11 0.3 6.13e-7 Hepatocellular carcinoma; CESC cis rs6800768 0.633 rs60635484 chr3:24101328 G/A cg10674438 chr3:24145617 LOC152024 -0.4 -5.38 -0.31 1.61e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1568889 0.838 rs11030265 chr11:28296168 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 13.35 0.63 1.98e-31 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17484976 chr20:60982411 CABLES2 -0.38 -6.01 -0.35 6e-9 Gambling; CESC cis rs643506 0.845 rs607327 chr11:111695709 C/T cg17089665 chr11:111648010 NA -0.36 -5.19 -0.3 4.21e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14064455 chr7:22862514 TOMM7 0.57 6.22 0.36 1.93e-9 Gut microbiome composition (summer); CESC cis rs4664304 0.966 rs3792198 chr2:160760338 G/A cg03641300 chr2:160917029 PLA2R1 -0.48 -6.78 -0.38 8.02e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg22800045 chr5:56110881 MAP3K1 0.49 5.83 0.34 1.58e-8 Coronary artery disease; CESC cis rs7116495 1.000 rs1939242 chr11:71753582 C/T cg26138937 chr11:71823887 C11orf51 -0.71 -5.95 -0.34 8.35e-9 Severe influenza A (H1N1) infection; CESC cis rs6060717 0.536 rs8125393 chr20:34496162 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -6.73 -0.38 1.07e-10 Hip circumference adjusted for BMI; CESC cis rs41271473 0.500 rs4606285 chr1:228887544 G/T cg00850481 chr1:228891306 NA -0.44 -6.1 -0.35 3.76e-9 Chronic lymphocytic leukemia; CESC cis rs672059 1.000 rs549844 chr1:183158143 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.54 -7.04 -0.4 1.64e-11 Hypertriglyceridemia; CESC cis rs708547 0.830 rs1713983 chr4:57883084 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -6.19 -0.36 2.34e-9 Response to bleomycin (chromatid breaks); CESC cis rs863345 0.608 rs11265013 chr1:158499625 G/A cg12129480 chr1:158549410 OR10X1 -0.32 -6.15 -0.35 2.82e-9 Pneumococcal bacteremia; CESC cis rs854765 0.724 rs2955371 chr17:17967397 G/A cg09796270 chr17:17721594 SREBF1 -0.44 -6.06 -0.35 4.57e-9 Total body bone mineral density; CESC cis rs9549367 0.789 rs6577034 chr13:113879900 T/C cg00898013 chr13:113819073 PROZ -0.51 -7.46 -0.42 1.21e-12 Platelet distribution width; CESC cis rs9611565 0.659 rs11090049 chr22:41915329 C/T cg17376030 chr22:41985996 PMM1 0.76 8.25 0.45 7.51e-15 Vitiligo; CESC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.54 -0.32 7.16e-8 Lung cancer; CESC cis rs2066819 1.000 rs2695782 chr12:56722830 C/T cg26714650 chr12:56694279 CS 1.34 15.3 0.68 2.7e-38 Psoriasis vulgaris; CESC trans rs4349753 0.663 rs62402074 chr5:144083358 A/C cg22407458 chr6:35109121 TCP11 0.5 6.31 0.36 1.18e-9 Photic sneeze reflex; CESC cis rs9611565 0.512 rs139571 chr22:42214238 G/A cg03806693 chr22:41940476 POLR3H -1.15 -13.11 -0.63 1.33e-30 Vitiligo; CESC cis rs4474465 0.920 rs908002 chr11:78144753 T/A cg27205649 chr11:78285834 NARS2 -0.41 -5.14 -0.3 5.25e-7 Alzheimer's disease (survival time); CESC cis rs9399135 0.933 rs41294852 chr6:135376379 T/G cg22676075 chr6:135203613 NA 0.53 7.45 0.42 1.36e-12 Red blood cell count; CESC cis rs7786808 0.608 rs6978352 chr7:158209802 T/C cg09998033 chr7:158218633 PTPRN2 0.37 5.45 0.32 1.17e-7 Obesity-related traits; CESC trans rs35883536 0.935 rs3904674 chr1:101138932 C/T cg16931499 chr17:42786676 DBF4B 0.41 6.09 0.35 3.98e-9 Monocyte count; CESC cis rs7264396 0.635 rs7263302 chr20:34545858 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -11.49 -0.58 4.75e-25 Total cholesterol levels; CESC cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.05e-7 Colonoscopy-negative controls vs population controls; CESC trans rs921968 0.541 rs578450 chr2:219401237 C/T cg15547669 chr20:2781122 CPXM1 0.35 6.0 0.35 6.31e-9 Mean corpuscular hemoglobin concentration; CESC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg05025164 chr4:1340916 KIAA1530 -0.64 -8.8 -0.48 1.8e-16 Obesity-related traits; CESC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg11859384 chr17:80120422 CCDC57 0.38 5.11 0.3 6.32e-7 Life satisfaction; CESC cis rs1371867 0.846 rs1660326 chr8:101290447 G/A cg11906718 chr8:101322791 RNF19A 0.5 6.34 0.36 9.95e-10 Atrioventricular conduction; CESC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg24531977 chr5:56204891 C5orf35 0.69 9.36 0.5 3.49e-18 Initial pursuit acceleration; CESC cis rs9905704 0.718 rs8072379 chr17:56615997 C/A cg12560992 chr17:57184187 TRIM37 -0.63 -6.02 -0.35 5.95e-9 Testicular germ cell tumor; CESC cis rs2637266 0.703 rs846591 chr10:78506321 A/C cg18941641 chr10:78392320 NA 0.38 7.49 0.42 1.06e-12 Pulmonary function; CESC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 11.93 0.59 1.55e-26 Platelet count; CESC cis rs932287 0.536 rs10840160 chr11:9053536 C/T cg12365402 chr11:9010492 NRIP3 -0.35 -5.39 -0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.583 rs9912895 chr17:17826020 C/T cg16928487 chr17:17741425 SREBF1 0.55 9.58 0.51 7.61e-19 Total body bone mineral density; CESC cis rs9303401 0.659 rs12600349 chr17:57054245 A/G cg12560992 chr17:57184187 TRIM37 -0.51 -5.06 -0.3 7.95e-7 Cognitive test performance; CESC cis rs6570726 0.791 rs9373466 chr6:145912016 T/C cg23711669 chr6:146136114 FBXO30 0.92 13.58 0.64 3.16e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs7178572 0.889 rs7177055 chr15:77832762 A/G cg22256960 chr15:77711686 NA 0.47 6.49 0.37 4.28e-10 Type 2 diabetes; CESC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg10800226 chr5:1850261 NA 0.32 5.21 0.3 3.84e-7 Cardiovascular disease risk factors; CESC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg22968622 chr17:43663579 NA 1.36 18.72 0.75 2.16e-50 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs62408225 1.000 rs11752685 chr6:90966415 A/C cg06866423 chr6:90926672 BACH2 0.45 5.43 0.32 1.29e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7208859 0.623 rs8068645 chr17:29104342 T/A cg13385521 chr17:29058706 SUZ12P 0.77 6.15 0.35 2.81e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11098499 0.863 rs13134665 chr4:120426430 T/C cg09307838 chr4:120376055 NA 0.95 13.07 0.63 1.87e-30 Corneal astigmatism; CESC cis rs7246657 0.943 rs10415937 chr19:37830064 T/G cg23950597 chr19:37808831 NA -0.55 -6.09 -0.35 3.96e-9 Coronary artery calcification; CESC cis rs9910055 0.659 rs8079310 chr17:42270291 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.44 6.37 0.36 8.52e-10 Total body bone mineral density; CESC cis rs1707322 1.000 rs10789485 chr1:46407308 C/T cg06784218 chr1:46089804 CCDC17 0.36 6.01 0.35 5.95e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7560272 0.589 rs34874205 chr2:73875458 G/A cg20560298 chr2:73613845 ALMS1 0.52 7.23 0.41 5.12e-12 Schizophrenia; CESC cis rs6460942 0.915 rs7803056 chr7:12306913 A/C cg02935154 chr7:12443704 VWDE -0.42 -5.58 -0.32 5.91e-8 Coronary artery disease; CESC cis rs2730245 0.592 rs2657385 chr7:158649373 A/G cg01943577 chr7:158741284 NA -0.44 -5.77 -0.33 2.19e-8 Height; CESC trans rs11722228 1.000 rs11722228 chr4:9915741 C/T cg26043149 chr18:55253948 FECH 0.48 6.49 0.37 4.22e-10 Gout;Urate levels;Serum uric acid levels; CESC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg08470875 chr2:26401718 FAM59B -0.74 -7.66 -0.43 3.41e-13 Gut microbiome composition (summer); CESC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg06634786 chr22:41940651 POLR3H -0.69 -6.71 -0.38 1.17e-10 Vitiligo; CESC cis rs2228479 0.850 rs57267516 chr16:89903552 G/A cg14709524 chr16:89940631 TCF25 0.75 5.35 0.31 1.95e-7 Skin colour saturation; CESC cis rs28374715 0.662 rs11852419 chr15:41456374 A/T cg18705301 chr15:41695430 NDUFAF1 0.75 10.38 0.54 2.13e-21 Ulcerative colitis; CESC cis rs17095355 0.786 rs58096078 chr10:111734286 C/G cg00817464 chr10:111662876 XPNPEP1 -0.45 -5.41 -0.32 1.42e-7 Biliary atresia; CESC cis rs5758659 0.714 rs133376 chr22:42466905 C/T cg05082376 chr22:42548792 NA -0.36 -5.21 -0.3 3.85e-7 Cognitive function; CESC cis rs754466 0.651 rs2004382 chr10:79650351 G/C cg17075019 chr10:79541650 NA -0.83 -12.1 -0.6 3.96e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2439831 0.850 rs12441861 chr15:44060883 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.72 6.94 0.39 3.08e-11 Lung cancer in ever smokers; CESC cis rs7208859 0.623 rs28556733 chr17:29083945 T/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs116161686 0.500 rs55871867 chr1:210051029 A/G cg21951975 chr1:209979733 IRF6 0.56 6.37 0.36 8.42e-10 Coronary artery disease; CESC cis rs854765 0.718 rs12943500 chr17:17790588 C/T cg09796270 chr17:17721594 SREBF1 -0.43 -5.76 -0.33 2.35e-8 Total body bone mineral density; CESC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.19 -0.4 6.61e-12 Personality dimensions; CESC cis rs5769765 1.000 rs764813 chr22:50286172 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.2 -0.3 4.05e-7 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16600432 chr14:64970085 ZBTB1;ZBTB25 -0.43 -6.37 -0.36 8.26e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7267979 1.000 rs6050602 chr20:25401203 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.03 -0.74 5.66e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs6088590 0.561 rs3891369 chr20:33161127 C/T cg24642439 chr20:33292090 TP53INP2 0.62 8.27 0.45 6.46e-15 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21367838 chr20:47805154 STAU1 0.56 6.42 0.37 6.38e-10 Gut microbiome composition (summer); CESC cis rs3733585 0.699 rs6449202 chr4:9974043 T/C cg02734326 chr4:10020555 SLC2A9 -0.4 -5.65 -0.33 4.11e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10129255 0.957 rs12590799 chr14:107187952 G/A cg23076370 chr14:107095027 NA -0.48 -6.13 -0.35 3.23e-9 Kawasaki disease; CESC cis rs4853012 0.941 rs7571083 chr2:74342260 C/G cg19729930 chr2:74357872 NA 0.77 10.48 0.54 9.92e-22 Gestational age at birth (maternal effect); CESC cis rs17539620 0.624 rs12665520 chr6:154835273 C/T cg17771515 chr6:154831774 CNKSR3 0.57 5.73 0.33 2.73e-8 Lipoprotein (a) levels; CESC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg20243544 chr17:37824526 PNMT 0.51 6.15 0.35 2.82e-9 Glomerular filtration rate (creatinine); CESC cis rs854765 0.583 rs8078105 chr17:17853782 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC cis rs6088580 0.668 rs1205340 chr20:32923871 G/A cg24642439 chr20:33292090 TP53INP2 -0.51 -6.66 -0.38 1.53e-10 Glomerular filtration rate (creatinine); CESC cis rs2200578 1.000 rs12053519 chr2:99875018 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.51 5.67 0.33 3.71e-8 IgG glycosylation; CESC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.76e-18 Skin colour saturation; CESC cis rs12136530 0.744 rs12090885 chr1:19779781 G/A cg01832549 chr1:19774989 CAPZB -0.48 -6.95 -0.39 2.8e-11 Lead levels in blood; CESC trans rs7781266 0.790 rs2113565 chr7:133185211 A/G cg06524120 chr15:77841106 NA 0.34 6.15 0.35 2.91e-9 Educational attainment (college completion); CESC cis rs4835473 0.932 rs17018500 chr4:144746002 A/G cg25736465 chr4:144833511 NA -0.34 -5.44 -0.32 1.21e-7 Immature fraction of reticulocytes; CESC cis rs344364 0.511 rs1742473 chr16:1953095 T/C cg26617929 chr16:1858877 NA -0.5 -5.21 -0.3 3.74e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs12956009 0.518 rs71352652 chr18:44869536 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.75 0.38 9.47e-11 Educational attainment (years of education); CESC cis rs1775715 0.737 rs12256714 chr10:32216262 A/G cg18675610 chr10:32216311 ARHGAP12 -0.36 -5.46 -0.32 1.08e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.0 0.39 2.15e-11 Colorectal cancer; CESC cis rs67311347 0.955 rs9821036 chr3:40379007 A/G cg24209194 chr3:40518798 ZNF619 0.42 5.36 0.31 1.82e-7 Renal cell carcinoma; CESC cis rs752010 0.545 rs6600379 chr1:42053497 T/C cg06885757 chr1:42089581 HIVEP3 0.48 7.59 0.42 5.35e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs17826219 0.568 rs2626985 chr17:29077437 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Body mass index; CESC trans rs208520 1.000 rs9453671 chr6:66991208 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 8.51 0.46 1.34e-15 Exhaled nitric oxide output; CESC cis rs929354 0.772 rs6971896 chr7:156978412 C/T cg05182265 chr7:156933206 UBE3C -0.51 -7.5 -0.42 9.58e-13 Body mass index; CESC cis rs3736485 0.966 rs8031903 chr15:51838161 C/T cg08986416 chr15:51914746 DMXL2 -0.39 -5.03 -0.3 9.11e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg11890956 chr21:40555474 PSMG1 -0.97 -16.63 -0.71 4.94e-43 Cognitive function; CESC trans rs3741489 1.000 rs10161328 chr12:133481884 C/A cg24132527 chr5:140019269 TMCO6 0.99 6.15 0.35 2.86e-9 Cognitive function; CESC cis rs13082711 0.911 rs11708710 chr3:27457348 A/C cg02860705 chr3:27208620 NA 0.59 7.39 0.41 1.94e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs12971120 0.891 rs2278159 chr18:72178161 T/C cg26446133 chr18:72167187 CNDP2 -0.74 -9.14 -0.49 1.69e-17 Refractive error; CESC cis rs9403521 1.000 rs6907410 chr6:143995142 A/G cg18240653 chr6:144019428 PHACTR2 -0.49 -5.57 -0.32 6.22e-8 Obesity-related traits; CESC cis rs941873 0.868 rs1483733 chr10:81130036 A/G cg09469691 chr10:81107165 PPIF 0.54 7.6 0.42 5.22e-13 Height; CESC cis rs7605827 0.930 rs13001923 chr2:15521264 A/T cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg08859206 chr1:53392774 SCP2 -0.59 -7.66 -0.43 3.5e-13 Monocyte count; CESC trans rs8073060 0.586 rs226084 chr17:34019582 T/A cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7666738 0.830 rs10031751 chr4:98939134 G/A cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2806561 0.765 rs1738469 chr1:23511407 G/C cg12483005 chr1:23474871 LUZP1 0.38 6.04 0.35 5.25e-9 Height; CESC cis rs9914988 0.832 rs4795462 chr17:27130991 C/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.46 -5.93 -0.34 9.36e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs17253792 0.915 rs75296402 chr14:56182491 C/T cg01858014 chr14:56050164 KTN1 -0.9 -7.2 -0.4 6.15e-12 Putamen volume; CESC trans rs2235573 0.625 rs3026677 chr22:38432725 C/G cg19894588 chr14:64061835 NA 0.48 6.13 0.35 3.14e-9 Glioblastoma;Glioma; CESC cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg18876405 chr7:65276391 NA -0.57 -7.63 -0.42 4.24e-13 Aortic root size; CESC cis rs7084402 0.967 rs1593672 chr10:60294379 T/C cg07615347 chr10:60278583 BICC1 0.62 9.85 0.52 1.05e-19 Refractive error; CESC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.15 -0.35 2.85e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01553388 chr7:158703170 WDR60 0.48 6.13 0.35 3.19e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13720 0.722 rs163800 chr20:57578508 C/T cg23907860 chr20:57583709 CTSZ 0.46 5.45 0.32 1.16e-7 Platelet distribution width; CESC cis rs826838 0.967 rs7299170 chr12:38789536 G/A cg13010199 chr12:38710504 ALG10B 0.6 8.53 0.46 1.1e-15 Heart rate; CESC cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg25427524 chr10:38739819 LOC399744 -0.65 -9.48 -0.5 1.51e-18 Extrinsic epigenetic age acceleration; CESC cis rs2286503 0.839 rs2240728 chr7:22852499 C/T cg13679077 chr7:22862647 TOMM7 0.45 5.77 0.33 2.2e-8 Fibrinogen; CESC cis rs11574514 1.000 rs8058835 chr16:67814865 C/T cg26727032 chr16:67993705 SLC12A4 -0.58 -5.23 -0.31 3.37e-7 Crohn's disease; CESC cis rs739401 0.595 rs6578304 chr11:2998279 A/G cg08508325 chr11:3079039 CARS 0.46 8.25 0.45 7.39e-15 Longevity; CESC cis rs2637266 0.685 rs2395427 chr10:78462535 G/A cg18941641 chr10:78392320 NA 0.4 7.17 0.4 7.65e-12 Pulmonary function; CESC cis rs2880765 0.835 rs12324277 chr15:86041735 G/A cg10818794 chr15:86012489 AKAP13 -0.33 -5.09 -0.3 6.94e-7 Coronary artery disease; CESC cis rs2066819 1.000 rs2306694 chr12:56680636 C/T cg26804944 chr12:56660921 COQ10A 0.85 5.19 0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs11122272 0.735 rs2247124 chr1:231493687 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.13 0.35 3.23e-9 Hemoglobin concentration; CESC trans rs55704346 0.566 rs28656285 chr4:25397026 C/A cg01822600 chr1:245751692 KIF26B 0.42 6.12 0.35 3.41e-9 Tonsillectomy; CESC cis rs1707322 0.686 rs2050376 chr1:46078630 C/T cg03146154 chr1:46216737 IPP 0.76 10.41 0.54 1.69e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7605827 0.930 rs4668898 chr2:15511502 T/C cg19274914 chr2:15703543 NA 0.31 5.51 0.32 8.66e-8 Educational attainment (years of education); CESC cis rs5769765 0.542 rs5769751 chr22:50242733 T/G cg02269571 chr22:50332266 NA 0.76 6.49 0.37 4.16e-10 Schizophrenia; CESC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg23754390 chr11:835074 CD151 0.33 5.99 0.35 6.68e-9 Mean platelet volume; CESC cis rs2456568 0.835 rs7936182 chr11:93665532 T/A cg26875233 chr11:93583750 C11orf90 -0.31 -5.44 -0.32 1.23e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs6426558 0.559 rs2813947 chr1:227459413 G/T cg10327440 chr1:227177885 CDC42BPA 0.49 6.09 0.35 4.02e-9 Neutrophil percentage of white cells; CESC cis rs11532322 1 rs11532322 chr12:123731423 A/G cg19016782 chr12:123741754 C12orf65 -0.36 -5.38 -0.31 1.66e-7 Schizophrenia; CESC cis rs11078597 0.731 rs8065251 chr17:1637458 G/A cg18436246 chr17:1640651 WDR81 0.61 7.43 0.42 1.46e-12 Serum albumin level; CESC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.37 -0.5 3.42e-18 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16435601 chr17:65822392 BPTF 0.56 6.16 0.35 2.75e-9 Gut microbiome composition (summer); CESC cis rs1044826 0.667 rs2083336 chr3:139201272 T/G cg00490450 chr3:139108681 COPB2 0.43 5.34 0.31 2.03e-7 Obesity-related traits; CESC cis rs10504073 0.669 rs341802 chr8:50039313 C/T cg00325661 chr8:49890786 NA 0.5 7.28 0.41 3.77e-12 Blood metabolite ratios; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13929079 chr12:49246153 DDX23 -0.43 -6.21 -0.36 2e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4319547 0.774 rs7959238 chr12:123131498 A/T cg05707623 chr12:122985044 ZCCHC8 -0.47 -5.7 -0.33 3.26e-8 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21192376 chr14:53020168 GPR137C;TXNDC16 0.6 6.61 0.38 2.13e-10 Gut microbiome composition (summer); CESC cis rs62432291 0.681 rs7757530 chr6:159647929 G/A cg14500486 chr6:159655392 FNDC1 0.6 6.01 0.35 6.09e-9 Joint mobility (Beighton score); CESC cis rs6815814 0.851 rs9715769 chr4:38774489 A/C cg02016764 chr4:38805732 TLR1 -0.68 -8.1 -0.45 2.06e-14 Breast cancer; CESC cis rs2980439 0.818 rs2945249 chr8:8094726 G/A cg06636001 chr8:8085503 FLJ10661 0.63 8.0 0.44 4.01e-14 Neuroticism; CESC cis rs3540 0.574 rs2657946 chr15:90967513 G/C cg22089800 chr15:90895588 ZNF774 0.62 8.16 0.45 1.36e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs826838 0.585 rs12296822 chr12:38625829 A/T cg26384229 chr12:38710491 ALG10B -0.43 -5.65 -0.33 4.09e-8 Heart rate; CESC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg22029157 chr1:209979665 IRF6 0.7 9.83 0.52 1.17e-19 Cleft lip with or without cleft palate; CESC cis rs28830936 1.000 rs4923905 chr15:41909889 G/A cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.36 -5.14 -0.3 5.26e-7 Diastolic blood pressure; CESC cis rs9488822 0.651 rs3798228 chr6:116321156 T/C cg18764771 chr6:116381957 FRK 0.22 5.44 0.32 1.21e-7 Cholesterol, total;LDL cholesterol; CESC cis rs4253772 0.938 rs45550937 chr22:46638128 C/G cg00784671 chr22:46762841 CELSR1 -0.51 -5.27 -0.31 2.87e-7 LDL cholesterol;Cholesterol, total; CESC cis rs55728055 0.661 rs16989334 chr22:32016092 A/G cg01338084 chr22:32026380 PISD 1.15 8.07 0.44 2.41e-14 Age-related hearing impairment; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg02284982 chr2:128145269 NA -0.45 -6.31 -0.36 1.19e-9 Recombination measurement; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17930852 chr1:45957182 TESK2 0.49 6.21 0.36 2e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs796364 0.616 rs7574313 chr2:200681040 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.57 5.23 0.31 3.39e-7 Schizophrenia; CESC cis rs3106136 1.000 rs2664871 chr4:95146281 A/G cg11021082 chr4:95130006 SMARCAD1 0.45 6.82 0.39 5.98e-11 Capecitabine sensitivity; CESC cis rs2070488 0.804 rs13100195 chr3:38482539 A/G cg24069376 chr3:38537580 EXOG 0.35 5.99 0.35 6.93e-9 Electrocardiographic conduction measures; CESC cis rs9790314 1.000 rs163328 chr3:161073599 A/G cg04691961 chr3:161091175 C3orf57 -0.41 -5.22 -0.31 3.68e-7 Morning vs. evening chronotype; CESC cis rs7512552 0.809 rs698923 chr1:150379159 G/A cg15654264 chr1:150340011 RPRD2 0.4 5.2 0.3 4.06e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.91 13.74 0.64 8.64e-33 Prudent dietary pattern; CESC cis rs854765 0.603 rs4506967 chr17:17990474 A/C cg04398451 chr17:18023971 MYO15A -0.75 -11.07 -0.56 1.18e-23 Total body bone mineral density; CESC cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg13902645 chr11:5959945 NA -0.62 -7.3 -0.41 3.35e-12 DNA methylation (variation); CESC cis rs7408868 1.000 rs1548554 chr19:15277938 C/T cg14696996 chr19:15285081 NOTCH3 1.11 11.94 0.59 1.43e-26 Pulse pressure; CESC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg07952391 chr2:88470173 THNSL2 -0.46 -6.76 -0.38 8.53e-11 Response to metformin (IC50); CESC cis rs829883 0.714 rs249847 chr12:98867716 C/T cg25150519 chr12:98850993 NA 0.85 14.78 0.67 1.79e-36 Colorectal adenoma (advanced); CESC cis rs2243480 1.000 rs316322 chr7:65611233 G/C cg13147721 chr7:65941812 NA -0.97 -9.15 -0.49 1.52e-17 Diabetic kidney disease; CESC cis rs9911578 1.000 rs4793950 chr17:56593111 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -5.31 -0.31 2.38e-7 Intelligence (multi-trait analysis); CESC cis rs1707322 1.000 rs6657720 chr1:46386269 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg17724175 chr1:150552817 MCL1 0.42 6.82 0.39 6.06e-11 Tonsillectomy; CESC cis rs6964587 1.000 rs10228800 chr7:91610111 T/G cg17063962 chr7:91808500 NA 0.57 7.74 0.43 2.11e-13 Breast cancer; CESC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs1062177 0.826 rs2915873 chr5:151156658 G/A cg00977110 chr5:151150581 G3BP1 0.62 6.76 0.38 8.65e-11 Preschool internalizing problems; CESC cis rs7818688 0.614 rs73269199 chr8:95841713 C/T cg16049864 chr8:95962084 TP53INP1 0.49 5.17 0.3 4.64e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg00800038 chr16:89945340 TCF25 -0.92 -7.62 -0.42 4.38e-13 Skin colour saturation; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00748821 chr4:83932227 LIN54 -0.45 -6.03 -0.35 5.37e-9 Height; CESC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg23708337 chr7:1209742 NA 0.49 5.36 0.31 1.77e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7072216 0.763 rs733346 chr10:100164325 A/C cg26618903 chr10:100175079 PYROXD2 -0.35 -5.33 -0.31 2.1e-7 Metabolite levels; CESC cis rs34779708 0.966 rs11010129 chr10:35510822 T/C cg03585969 chr10:35415529 CREM 0.75 9.46 0.5 1.78e-18 Inflammatory bowel disease;Crohn's disease; CESC cis rs13102973 0.965 rs4864240 chr4:135856737 T/C cg14419869 chr4:135874104 NA -0.38 -6.02 -0.35 5.82e-9 Subjective well-being; CESC cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 5.91 0.34 1.07e-8 Colonoscopy-negative controls vs population controls; CESC cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg25019033 chr10:957182 NA -0.6 -6.19 -0.36 2.24e-9 Eosinophil percentage of granulocytes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16075951 chr14:24899050 CBLN3;KHNYN -0.47 -6.72 -0.38 1.1e-10 Fibrinogen levels; CESC cis rs1927790 0.727 rs12867783 chr13:96974576 A/T cg02571835 chr13:96230311 CLDN10 -0.36 -5.21 -0.3 3.83e-7 Body mass index; CESC trans rs4650994 0.525 rs4993304 chr1:178535144 A/G cg05059571 chr16:84539110 KIAA1609 -0.4 -6.18 -0.35 2.36e-9 HDL cholesterol levels;HDL cholesterol; CESC cis rs2070997 0.667 rs7042528 chr9:133686717 T/G cg11464064 chr9:133710261 ABL1 0.57 6.36 0.36 8.71e-10 Response to amphetamines; CESC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg11890956 chr21:40555474 PSMG1 0.65 9.2 0.49 1.11e-17 Menarche (age at onset); CESC cis rs9911578 0.935 rs6503878 chr17:56884581 T/G cg12560992 chr17:57184187 TRIM37 0.92 15.58 0.69 2.71e-39 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.22e-17 Prudent dietary pattern; CESC cis rs4812048 0.901 rs151355 chr20:57607645 G/C cg14073986 chr20:57617431 SLMO2 0.55 5.79 0.33 2.01e-8 Mean platelet volume; CESC cis rs2276314 0.793 rs77590522 chr18:33629410 C/G cg05985134 chr18:33552581 C18orf21 0.64 7.27 0.41 4.15e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg26338869 chr17:61819248 STRADA 0.67 8.8 0.48 1.77e-16 Prudent dietary pattern; CESC cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg10523679 chr1:76189770 ACADM -0.69 -7.15 -0.4 8.47e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3126085 0.825 rs7535078 chr1:152222915 T/C cg03465714 chr1:152285911 FLG -0.43 -5.43 -0.32 1.27e-7 Atopic dermatitis; CESC cis rs35146811 0.622 rs6946204 chr7:99589125 T/C cg14163444 chr7:99595348 NA -0.39 -5.24 -0.31 3.3e-7 Coronary artery disease; CESC cis rs642803 0.613 rs565427 chr11:65532825 G/A cg08755490 chr11:65554678 OVOL1 0.43 5.55 0.32 6.76e-8 Urate levels; CESC cis rs12586317 0.547 rs10146699 chr14:35483577 G/A cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.22e-22 Psoriasis; CESC cis rs992157 0.560 rs4674275 chr2:219097738 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.57 -7.45 -0.42 1.29e-12 Colorectal cancer; CESC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg12740337 chr6:28058973 ZSCAN12L1 0.34 5.04 0.3 8.76e-7 Depression; CESC cis rs7258465 0.965 rs10409003 chr19:18543054 C/T cg25828334 chr19:18545568 ISYNA1 -0.32 -5.21 -0.3 3.84e-7 Breast cancer; CESC cis rs1729951 0.575 rs35289288 chr3:136680568 C/T cg25687071 chr3:136751404 NA 0.39 5.17 0.3 4.72e-7 Neuroticism; CESC cis rs2120019 0.938 rs2120020 chr15:75316845 T/C cg17294928 chr15:75287854 SCAMP5 -0.76 -8.73 -0.47 3e-16 Blood trace element (Zn levels); CESC cis rs9815354 0.812 rs78342280 chr3:41948810 G/A cg03022575 chr3:42003672 ULK4 0.71 6.45 0.37 5.42e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs965469 1.000 rs2281503 chr20:3263636 G/A cg25506879 chr20:3388711 C20orf194 -0.55 -5.98 -0.35 7.01e-9 IFN-related cytopenia; CESC cis rs16957304 1.000 rs8050745 chr16:67311767 G/A cg26727032 chr16:67993705 SLC12A4 -0.54 -5.33 -0.31 2.09e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs9640161 0.871 rs56156367 chr7:150047201 A/T cg21361702 chr7:150065534 REPIN1 0.48 5.12 0.3 5.96e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs853679 1.000 rs853694 chr6:28279100 A/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.68 7.27 0.41 4.07e-12 Depression; CESC cis rs7589342 0.899 rs10185551 chr2:106492201 A/C cg16077055 chr2:106428750 NCK2 0.47 6.94 0.39 2.94e-11 Addiction; CESC cis rs568617 1.000 rs568617 chr11:65653242 C/T cg00576331 chr11:65640516 EFEMP2 -0.45 -5.35 -0.31 1.95e-7 Crohn's disease; CESC cis rs2050392 0.894 rs2480277 chr10:30703513 G/T cg18806716 chr10:30721971 MAP3K8 0.43 6.12 0.35 3.26e-9 Inflammatory bowel disease; CESC cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg21214613 chr1:16344536 HSPB7 0.37 5.25 0.31 3.1e-7 Dilated cardiomyopathy; CESC cis rs9911578 1.000 rs12947785 chr17:57045160 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.08 0.3 7.21e-7 Intelligence (multi-trait analysis); CESC cis rs9611565 0.559 rs132771 chr22:42025350 A/G cg06634786 chr22:41940651 POLR3H 0.59 6.01 0.35 6.19e-9 Vitiligo; CESC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04624059 chr7:99063424 ATP5J2 0.49 6.2 0.36 2.21e-9 Gut microbiota (bacterial taxa); CESC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Tonsillectomy; CESC cis rs2294693 0.945 rs9369255 chr6:40989503 T/C cg14418226 chr6:40996092 UNC5CL 0.53 6.34 0.36 9.61e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs6120849 0.754 rs6120788 chr20:33583716 C/T cg24642439 chr20:33292090 TP53INP2 0.66 6.52 0.37 3.59e-10 Protein C levels; CESC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg18876405 chr7:65276391 NA 0.5 6.68 0.38 1.43e-10 Aortic root size; CESC cis rs62458065 0.513 rs9655340 chr7:32535920 A/G cg20159608 chr7:32802032 NA 0.55 6.16 0.35 2.74e-9 Metabolite levels (HVA/MHPG ratio); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16424138 chr5:14581771 FAM105A -0.4 -6.23 -0.36 1.86e-9 Gambling; CESC cis rs9913156 0.589 rs7213481 chr17:4547906 C/T cg19197139 chr17:4613644 ARRB2 0.93 10.3 0.53 3.78e-21 Lymphocyte counts; CESC cis rs116095464 0.558 rs10055993 chr5:264296 A/C cg22496380 chr5:211416 CCDC127 -0.98 -9.81 -0.52 1.42e-19 Breast cancer; CESC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg21782813 chr7:2030301 MAD1L1 0.42 6.13 0.35 3.12e-9 Bipolar disorder and schizophrenia; CESC cis rs9287719 0.967 rs6709466 chr2:10748257 T/C cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC trans rs7628583 0.877 rs12494731 chr3:64082003 G/T cg08723793 chr12:861752 WNK1 -0.59 -6.02 -0.35 5.81e-9 Parental extreme longevity (95 years and older); CESC cis rs2463822 1.000 rs12279819 chr11:62137245 G/A cg06239285 chr11:62104954 ASRGL1 -0.96 -8.49 -0.46 1.54e-15 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs637571 0.524 rs674363 chr11:65699134 G/A cg02427764 chr11:65769310 BANF1;EIF1AD -0.63 -8.23 -0.45 8.45e-15 Eosinophil percentage of white cells; CESC cis rs1707322 1.000 rs1768800 chr1:46549188 A/G cg03146154 chr1:46216737 IPP -0.69 -9.04 -0.49 3.51e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11857246 chr1:11741390 MAD2L2 -0.47 -6.08 -0.35 4.18e-9 Fibrinogen levels; CESC cis rs1949733 1.000 rs6447875 chr4:8503206 T/C cg11789530 chr4:8429930 ACOX3 0.74 10.46 0.54 1.14e-21 Response to antineoplastic agents; CESC cis rs7662987 0.517 rs2851256 chr4:100039549 G/A cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.2 -0.36 2.21e-9 Parkinson's disease; CESC cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg07697082 chr8:82753677 SNX16 -0.39 -6.12 -0.35 3.32e-9 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02331450 chr3:33155354 CRTAP 0.66 8.14 0.45 1.52e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04158140 chr7:71407448 CALN1 -0.53 -6.09 -0.35 4.03e-9 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.73 0.38 1.07e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03786933 chr16:69760418 NQO1 0.56 6.03 0.35 5.57e-9 Gut microbiome composition (summer); CESC trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg03929089 chr4:120376271 NA 0.78 11.75 0.59 5.9e-26 Coronary artery disease; CESC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg14159672 chr1:205819179 PM20D1 0.79 12.05 0.59 6.01e-27 Menarche (age at onset); CESC cis rs1707322 1.000 rs6429580 chr1:46275648 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.7 0.33 3.24e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6987853 0.787 rs2974335 chr8:42417272 C/T cg09913449 chr8:42400586 C8orf40 0.45 7.44 0.42 1.39e-12 Mean corpuscular hemoglobin concentration; CESC cis rs12042052 1.000 rs6669303 chr1:232912728 G/A cg00951395 chr1:232941775 KIAA1383 0.7 6.94 0.39 3.02e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.74 7.36 0.41 2.29e-12 Platelet count; CESC cis rs7605827 0.930 rs11692377 chr2:15659848 C/T cg19274914 chr2:15703543 NA 0.36 6.31 0.36 1.18e-9 Educational attainment (years of education); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg11038604 chr10:14996337 DCLRE1C -0.47 -6.04 -0.35 5.3e-9 Thyroid stimulating hormone; CESC cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg15017067 chr4:17643749 FAM184B 0.38 5.35 0.31 1.86e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 12.0 0.59 9.03e-27 Alzheimer's disease; CESC cis rs11122272 0.735 rs11122281 chr1:231519842 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.11 0.35 3.47e-9 Hemoglobin concentration; CESC cis rs9894429 0.646 rs8080391 chr17:79566319 A/T cg13777783 chr17:79615861 NA 0.34 5.39 0.31 1.53e-7 Eye color traits; CESC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg08470875 chr2:26401718 FAM59B -0.47 -5.22 -0.31 3.6e-7 Gut microbiome composition (summer); CESC cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.45 -5.4 -0.31 1.49e-7 Schizophrenia; CESC cis rs6500395 1.000 rs9933329 chr16:48646572 T/C cg04672837 chr16:48644449 N4BP1 0.5 6.07 0.35 4.3e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs2832077 0.527 rs2832116 chr21:30228368 C/A cg14791747 chr16:20752902 THUMPD1 0.53 7.48 0.42 1.12e-12 Cognitive test performance; CESC cis rs7772486 0.720 rs9403757 chr6:146261271 C/T cg05347473 chr6:146136440 FBXO30 -0.55 -7.0 -0.39 2.12e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.719 rs4699323 chr4:98967484 G/A cg05340658 chr4:99064831 C4orf37 0.5 5.61 0.33 5.04e-8 Colonoscopy-negative controls vs population controls; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg25192855 chr1:209979283 IRF6 0.32 6.01 0.35 6.04e-9 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs6460942 0.915 rs62447641 chr7:12488764 G/A cg20607287 chr7:12443886 VWDE -0.76 -8.61 -0.47 6.79e-16 Coronary artery disease; CESC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg26314531 chr2:26401878 FAM59B 0.85 9.23 0.49 8.65e-18 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg14893161 chr1:205819251 PM20D1 0.98 18.76 0.76 1.49e-50 Menarche (age at onset); CESC cis rs9902453 0.868 rs11080118 chr17:28475379 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.74 -0.43 2.11e-13 Coffee consumption (cups per day); CESC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg05890377 chr2:74357713 NA 0.56 6.58 0.37 2.51e-10 Gestational age at birth (maternal effect); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12733656 chr7:6388695 C7orf70 0.58 6.11 0.35 3.62e-9 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs76612185 chr14:56037706 T/C cg01858014 chr14:56050164 KTN1 -0.94 -6.77 -0.38 8.05e-11 Putamen volume; CESC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg16405210 chr4:1374714 KIAA1530 -0.49 -6.2 -0.36 2.2e-9 Obesity-related traits; CESC cis rs5758659 0.652 rs133340 chr22:42417687 A/T cg04733989 chr22:42467013 NAGA -0.4 -5.36 -0.31 1.85e-7 Cognitive function; CESC cis rs2797685 1.000 rs2640908 chr1:7889941 C/T cg04725166 chr1:7887271 PER3 -0.47 -6.42 -0.37 6.44e-10 Crohn's disease; CESC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg00149659 chr3:10157352 C3orf10 0.71 8.45 0.46 2.01e-15 Alzheimer's disease; CESC cis rs7191700 0.674 rs12597893 chr16:11426331 A/G cg00044050 chr16:11439710 C16orf75 0.46 5.71 0.33 3.02e-8 Multiple sclerosis; CESC cis rs4704187 0.687 rs9293643 chr5:74365053 C/T cg03227963 chr5:74354835 NA -0.3 -5.6 -0.33 5.45e-8 Response to amphetamines; CESC cis rs965469 1.000 rs6139068 chr20:3284393 G/A cg25506879 chr20:3388711 C20orf194 -0.58 -6.15 -0.35 2.79e-9 IFN-related cytopenia; CESC cis rs9291683 0.595 rs13150928 chr4:10052961 G/T cg02734326 chr4:10020555 SLC2A9 0.48 6.82 0.39 6.29e-11 Bone mineral density; CESC cis rs6912958 0.559 rs242270 chr6:88062190 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.71 -10.74 -0.55 1.42e-22 Monocyte percentage of white cells; CESC cis rs2011503 0.882 rs10401714 chr19:19363630 G/A cg11584989 chr19:19387371 SF4 0.53 6.41 0.37 6.52e-10 Bipolar disorder; CESC cis rs7584330 0.554 rs10178682 chr2:238433818 T/G cg14458575 chr2:238380390 NA 0.49 5.42 0.32 1.35e-7 Prostate cancer; CESC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg05564831 chr3:52568323 NT5DC2 0.46 7.38 0.41 2.06e-12 Bipolar disorder; CESC cis rs10992471 0.756 rs2516568 chr9:95187380 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -5.73 -0.33 2.77e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg25072359 chr17:41440525 NA 0.52 7.53 0.42 8e-13 Menopause (age at onset); CESC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.44 0.42 1.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1153858 1.000 rs4775909 chr15:45643042 T/C cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19942813 chr3:187463496 BCL6 0.44 6.01 0.35 6e-9 Gut microbiota (bacterial taxa); CESC cis rs1395 0.778 rs2580761 chr2:27426362 G/A cg22903471 chr2:27725779 GCKR -0.42 -5.21 -0.3 3.81e-7 Blood metabolite levels; CESC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg26314531 chr2:26401878 FAM59B -0.85 -9.04 -0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.52 0.37 3.63e-10 Prudent dietary pattern; CESC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.71e-16 Initial pursuit acceleration; CESC cis rs858239 0.632 rs1985769 chr7:23122506 T/G cg23682824 chr7:23144976 KLHL7 0.54 7.54 0.42 7.42e-13 Cerebrospinal fluid biomarker levels; CESC cis rs17253792 0.822 rs76055105 chr14:56069127 A/G cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs847577 1.000 rs847577 chr7:97694858 T/A cg24562669 chr7:97807699 LMTK2 -0.64 -10.43 -0.54 1.45e-21 Breast cancer; CESC cis rs9987353 0.544 rs2929470 chr8:9062490 A/G cg15556689 chr8:8085844 FLJ10661 -0.43 -5.03 -0.3 9.18e-7 Recombination measurement; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01594214 chr6:123110554 SMPDL3A 0.61 7.13 0.4 9.49e-12 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9486719 0.895 rs34051754 chr6:97007754 A/T cg06623918 chr6:96969491 KIAA0776 -0.8 -8.3 -0.45 5.39e-15 Migraine;Coronary artery disease; CESC cis rs1950626 0.623 rs4402490 chr14:101445453 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.67 -9.14 -0.49 1.7e-17 Pelvic organ prolapse (moderate/severe); CESC cis rs6424115 0.830 rs2502994 chr1:24199363 T/C cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC cis rs9486719 0.843 rs3849198 chr6:97036539 C/A cg18709589 chr6:96969512 KIAA0776 -0.5 -5.44 -0.32 1.21e-7 Migraine;Coronary artery disease; CESC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.93 0.39 3.18e-11 Electroencephalogram traits; CESC trans rs875971 0.964 rs778723 chr7:65829497 T/C cg26939375 chr7:64535504 NA 0.47 6.14 0.35 3e-9 Aortic root size; CESC cis rs916888 0.779 rs430685 chr17:44859148 T/C cg01570182 chr17:44337453 NA -0.88 -10.64 -0.55 2.96e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10131894 0.611 rs175002 chr14:75436466 C/G cg11812906 chr14:75593930 NEK9 0.64 9.79 0.52 1.68e-19 Coronary artery disease; CESC cis rs7103648 0.864 rs10769264 chr11:47423340 C/T cg20307385 chr11:47447363 PSMC3 0.97 16.8 0.72 1.29e-43 Diastolic blood pressure;Systolic blood pressure; CESC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.38 5.28 0.31 2.73e-7 Lymphocyte counts; CESC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs7843479 0.582 rs11135743 chr8:21803008 A/G cg17168535 chr8:21777572 XPO7 0.73 12.01 0.59 8.24e-27 Mean corpuscular volume; CESC cis rs17376456 0.757 rs10066431 chr5:93198204 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.37 0.31 1.74e-7 Diabetic retinopathy; CESC cis rs10851478 0.872 rs55904469 chr15:49789971 G/A cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.22 0.31 3.56e-7 Oral cavity cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00692971 chr15:101142510 ASB7;LINS1 -0.47 -6.32 -0.36 1.12e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3820068 0.581 rs74054797 chr1:15926217 G/A cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs3733585 0.699 rs7699609 chr4:9961059 A/G cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs12142240 0.698 rs17357621 chr1:46807697 C/T cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg24324837 chr19:49891574 CCDC155 0.5 5.97 0.34 7.77e-9 Multiple sclerosis; CESC cis rs7843479 0.543 rs10866823 chr8:21781629 C/T cg17168535 chr8:21777572 XPO7 0.75 12.02 0.59 7.62e-27 Mean corpuscular volume; CESC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg00149659 chr3:10157352 C3orf10 0.72 9.05 0.49 3.14e-17 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01335785 chr19:7505029 ARHGEF18 -0.55 -6.14 -0.35 2.99e-9 Gut microbiome composition (summer); CESC cis rs11741688 0.557 rs6897783 chr5:178330574 G/A cg20935368 chr5:178288625 ZNF354B 0.34 5.4 0.32 1.45e-7 Sleep duration; CESC cis rs2404602 0.692 rs7163397 chr15:76940315 A/G cg26408565 chr15:76604113 ETFA -0.39 -5.56 -0.32 6.72e-8 Blood metabolite levels; CESC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg14893161 chr1:205819251 PM20D1 0.89 15.4 0.69 1.2e-38 Menarche (age at onset); CESC cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg02297831 chr4:17616191 MED28 0.6 7.59 0.42 5.34e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10823500 0.640 rs7077538 chr10:71993094 T/G cg04118878 chr10:71993077 PPA1 0.53 6.33 0.36 1.02e-9 Blood protein levels; CESC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg16680214 chr1:154839983 KCNN3 -0.51 -8.02 -0.44 3.39e-14 Prostate cancer; CESC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg05861140 chr6:150128134 PCMT1 -0.38 -5.43 -0.32 1.29e-7 Lung cancer; CESC cis rs4423214 1.000 rs2276361 chr11:71169648 A/G cg05163923 chr11:71159392 DHCR7 0.85 11.46 0.58 5.81e-25 Vitamin D levels; CESC cis rs7680126 0.633 rs55766779 chr4:10287039 C/T cg11266682 chr4:10021025 SLC2A9 -0.45 -5.69 -0.33 3.42e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs4835473 0.770 rs4835096 chr4:144881838 G/C cg25736465 chr4:144833511 NA 0.39 5.87 0.34 1.31e-8 Immature fraction of reticulocytes; CESC cis rs7474896 0.583 rs7071147 chr10:38003376 T/C cg25427524 chr10:38739819 LOC399744 -0.48 -5.6 -0.33 5.35e-8 Obesity (extreme); CESC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg14159672 chr1:205819179 PM20D1 0.73 10.65 0.55 2.73e-22 Menarche (age at onset); CESC cis rs72781680 0.752 rs72796116 chr2:23913769 C/T cg20701182 chr2:24300061 SF3B14 0.8 6.89 0.39 3.98e-11 Lymphocyte counts; CESC cis rs3741151 0.686 rs7129990 chr11:73124441 A/G cg17517138 chr11:73019481 ARHGEF17 0.57 5.45 0.32 1.13e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs2228479 0.557 rs62054639 chr16:89821489 C/T cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs796364 1.000 rs281788 chr2:200783705 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.89 8.76 0.47 2.43e-16 Schizophrenia; CESC cis rs6546550 0.901 rs13028508 chr2:70118427 A/T cg02498382 chr2:70120550 SNRNP27 0.41 7.26 0.41 4.4e-12 Prevalent atrial fibrillation; CESC cis rs12477438 0.501 rs7349217 chr2:99815146 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 15.87 0.7 2.51e-40 Chronic sinus infection; CESC cis rs1568889 1.000 rs58502944 chr11:28060943 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 10.82 0.55 7.89e-23 Bipolar disorder; CESC cis rs12451471 0.559 rs1042396 chr17:78084769 G/A cg06718696 chr17:78121285 EIF4A3 0.79 9.46 0.5 1.75e-18 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs11098499 1.000 rs28374891 chr4:120183550 G/A cg09307838 chr4:120376055 NA 0.87 11.56 0.58 2.66e-25 Corneal astigmatism; CESC cis rs9640161 0.830 rs6722 chr7:150068933 T/C cg10018233 chr7:150070692 REPIN1 0.5 9.5 0.5 1.32e-18 Blood protein levels;Circulating chemerin levels; CESC cis rs2070433 0.799 rs7279002 chr21:47910523 C/T cg12379764 chr21:47803548 PCNT -0.48 -5.79 -0.34 1.95e-8 Lymphocyte counts; CESC cis rs265548 0.608 rs36690 chr19:17910483 C/T cg16744531 chr19:17905626 B3GNT3 0.59 8.25 0.45 7.64e-15 Tumor biomarkers; CESC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg04166393 chr7:2884313 GNA12 0.61 8.37 0.46 3.4e-15 Height; CESC cis rs7605827 0.930 rs11687702 chr2:15682857 T/C cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs7091068 0.616 rs1409336 chr10:95479674 T/G cg20715218 chr10:95462985 C10orf4 0.55 5.55 0.32 6.92e-8 Urinary tract infection frequency; CESC cis rs926938 0.527 rs360681 chr1:115496741 C/G cg12756093 chr1:115239321 AMPD1 0.44 6.13 0.35 3.24e-9 Autism; CESC cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.19 0.3 4.29e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7847628 0.550 rs12343516 chr9:123603469 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 7.87 0.44 8.87e-14 Birth weight; CESC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs6460942 0.915 rs7803051 chr7:12306904 A/T cg06484146 chr7:12443880 VWDE -0.47 -6.41 -0.37 6.52e-10 Coronary artery disease; CESC cis rs2204008 0.606 rs1581358 chr12:38391582 G/T cg13010199 chr12:38710504 ALG10B 0.53 6.42 0.37 6.13e-10 Bladder cancer; CESC cis rs6582630 0.519 rs11495699 chr12:38286219 G/T cg26384229 chr12:38710491 ALG10B 0.71 9.77 0.51 1.9e-19 Drug-induced liver injury (flucloxacillin); CESC cis rs4718428 0.705 rs4717328 chr7:66352665 T/C cg25985355 chr7:65971099 NA -0.35 -5.11 -0.3 6.03e-7 Corneal structure; CESC cis rs644799 0.625 rs1255177 chr11:95471495 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.5 6.94 0.39 2.96e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7546094 1.000 rs2999155 chr1:113221658 G/A cg22162597 chr1:113214053 CAPZA1 -0.39 -5.95 -0.34 8.53e-9 Platelet distribution width; CESC cis rs12541635 0.934 rs62527400 chr8:107054229 G/A cg10147462 chr8:107024639 NA 0.43 6.01 0.35 6.12e-9 Age of smoking initiation; CESC cis rs7927592 0.956 rs7113287 chr11:68372186 A/T cg20283391 chr11:68216788 NA -0.47 -5.94 -0.34 8.73e-9 Total body bone mineral density; CESC cis rs6089584 0.566 rs6061963 chr20:60607480 C/G cg24733560 chr20:60626293 TAF4 0.45 6.66 0.38 1.55e-10 Body mass index; CESC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg13206674 chr6:150067644 NUP43 0.44 6.31 0.36 1.16e-9 Lung cancer; CESC trans rs526821 0.595 rs499446 chr11:55355722 A/G cg03929089 chr4:120376271 NA -0.5 -6.07 -0.35 4.33e-9 Pediatric bone mineral density (spine); CESC cis rs11155671 0.530 rs4869763 chr6:150211684 T/C cg09699651 chr6:150184138 LRP11 0.55 7.64 0.42 3.95e-13 Testicular germ cell tumor; CESC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg11905131 chr22:24372483 LOC391322 -0.82 -12.08 -0.6 4.77e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13866129 chr11:62623438 SNORD27;SLC3A2;SNORD28;SNORD25;SNORD26;SNHG1 0.43 6.06 0.35 4.74e-9 Gut microbiota (bacterial taxa); CESC cis rs3820068 0.603 rs56032936 chr1:15970953 T/C cg13390004 chr1:15929781 NA 0.36 5.74 0.33 2.61e-8 Systolic blood pressure; CESC cis rs763014 0.931 rs2071982 chr16:630405 T/G cg00908189 chr16:619842 PIGQ 0.67 9.39 0.5 2.81e-18 Height; CESC cis rs4253772 0.614 rs11090859 chr22:46687460 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.78 9.17 0.49 1.32e-17 LDL cholesterol;Cholesterol, total; CESC cis rs7084402 0.935 rs10763553 chr10:60274049 C/A cg07615347 chr10:60278583 BICC1 -0.57 -9.01 -0.48 4.08e-17 Refractive error; CESC cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg24296786 chr1:45957014 TESK2 -0.58 -7.71 -0.43 2.58e-13 Red blood cell count;Reticulocyte count; CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06045062 chr4:100009749 ADH5 0.63 7.54 0.42 7.69e-13 Gut microbiome composition (summer); CESC cis rs644799 1.000 rs644799 chr11:95564259 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.66 0.38 1.6e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7833986 0.501 rs2953898 chr8:56980803 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 6.89e-13 Height; CESC cis rs3008870 0.755 rs1925410 chr1:67365230 C/T cg02640540 chr1:67518911 SLC35D1 -0.47 -5.71 -0.33 3.03e-8 Lymphocyte percentage of white cells; CESC cis rs4595586 0.505 rs11615603 chr12:39409450 C/G cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11228005 chr3:197477097 FYTTD1;KIAA0226 0.67 7.39 0.41 1.92e-12 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg08888203 chr3:10149979 C3orf24 0.45 5.71 0.33 3.04e-8 Alzheimer's disease; CESC cis rs72829446 0.530 rs11869864 chr17:7407766 C/A cg02795151 chr17:7402630 POLR2A 0.6 6.56 0.37 2.83e-10 Androgen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09265274 chr17:48585635 MYCBPAP -0.59 -7.21 -0.4 6.02e-12 Gut microbiome composition (summer); CESC cis rs4629180 0.586 rs1509495 chr2:102134834 C/T cg04415270 chr2:102091202 RFX8 -0.32 -5.33 -0.31 2.1e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs6915183 1.000 rs6934656 chr6:166706121 A/G cg14022523 chr6:166756177 SFT2D1 -0.53 -7.05 -0.4 1.54e-11 Longevity; CESC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg05313129 chr8:58192883 C8orf71 -0.53 -6.13 -0.35 3.11e-9 Developmental language disorder (linguistic errors); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02951695 chr10:134400351 INPP5A 0.49 6.3 0.36 1.21e-9 Fibrinogen levels; CESC cis rs10905065 0.965 rs10795520 chr10:5764160 G/A cg11519256 chr10:5708881 ASB13 0.46 6.23 0.36 1.84e-9 Menopause (age at onset); CESC cis rs7208859 0.623 rs9915546 chr17:29132144 G/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg22875332 chr1:76189707 ACADM 0.58 5.73 0.33 2.66e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7503807 0.837 rs9915667 chr17:78754340 A/G cg09596252 chr17:78655493 RPTOR -0.43 -5.82 -0.34 1.66e-8 Obesity; CESC cis rs7666738 0.546 rs11727151 chr4:98837353 A/C cg05340658 chr4:99064831 C4orf37 0.52 6.33 0.36 1.04e-9 Colonoscopy-negative controls vs population controls; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg23285320 chr19:36546349 THAP8;WDR62 -0.57 -6.42 -0.37 6.35e-10 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10771518 chr10:115439279 CASP7 0.58 6.89 0.39 4.03e-11 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.2 0.3 3.96e-7 Menopause (age at onset); CESC cis rs2760061 0.626 rs591582 chr1:228117360 C/A cg01973587 chr1:228161476 NA 0.36 5.44 0.32 1.22e-7 Diastolic blood pressure; CESC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg13628971 chr7:2884303 GNA12 0.64 8.78 0.47 2.11e-16 Height; CESC cis rs66887589 0.967 rs59516282 chr4:120502016 G/A cg09307838 chr4:120376055 NA -0.52 -7.05 -0.4 1.56e-11 Diastolic blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22967283 chr7:4815538 KIAA0415 -0.45 -6.09 -0.35 3.94e-9 Fibrinogen levels; CESC cis rs6032067 0.929 rs17424668 chr20:43809647 C/T cg11264863 chr20:43835661 SEMG1 -0.48 -5.37 -0.31 1.7e-7 Blood protein levels; CESC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg18225595 chr11:63971243 STIP1 0.52 5.19 0.3 4.19e-7 Mean platelet volume; CESC cis rs8062405 0.755 rs4788080 chr16:28558081 C/T cg01378222 chr16:28622494 SULT1A1 0.3 5.14 0.3 5.27e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg11890956 chr21:40555474 PSMG1 1.18 24.03 0.83 1.59e-68 Cognitive function; CESC cis rs2839186 0.934 rs13046494 chr21:47707430 A/C cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 7.02e-11 Testicular germ cell tumor; CESC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg00149659 chr3:10157352 C3orf10 0.75 9.05 0.49 3.07e-17 Alzheimer's disease; CESC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg02187348 chr16:89574699 SPG7 0.64 8.84 0.48 1.39e-16 Multiple myeloma (IgH translocation); CESC cis rs6570726 0.846 rs371186 chr6:145886971 T/C cg23711669 chr6:146136114 FBXO30 0.85 12.88 0.62 8.09e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs9457247 0.561 rs916331 chr6:167470559 T/G cg07741184 chr6:167504864 NA 0.38 6.7 0.38 1.22e-10 Crohn's disease; CESC trans rs7618501 0.572 rs4688756 chr3:50040194 T/A cg21659725 chr3:3221576 CRBN 0.49 6.9 0.39 3.78e-11 Intelligence (multi-trait analysis); CESC cis rs3020736 0.500 rs11090076 chr22:42514190 T/C cg15557168 chr22:42548783 NA 0.45 6.51 0.37 3.78e-10 Autism spectrum disorder or schizophrenia; CESC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg23161317 chr6:28129485 ZNF389 0.38 5.2 0.3 3.97e-7 Parkinson's disease; CESC cis rs3091242 0.836 rs34997029 chr1:25783823 A/G cg03538708 chr1:25844672 NA 0.4 5.95 0.34 8.36e-9 Erythrocyte sedimentation rate; CESC cis rs12410462 1.000 rs75637482 chr1:227622944 A/T cg04117972 chr1:227635322 NA 0.62 6.34 0.36 9.91e-10 Major depressive disorder; CESC cis rs1682361 1 rs1682361 chr3:136734014 G/C cg03617693 chr3:136751559 NA 0.45 6.53 0.37 3.35e-10 Schizophrenia; CESC cis rs72781680 0.898 rs72780125 chr2:24000145 T/C cg08917208 chr2:24149416 ATAD2B 1.13 10.18 0.53 9.42e-21 Lymphocyte counts; CESC cis rs10870270 1.000 rs6560694 chr10:133773448 G/A cg17892150 chr10:133769511 PPP2R2D -0.86 -12.56 -0.61 1.08e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1538970 0.816 rs3790583 chr1:45956828 C/G cg24296786 chr1:45957014 TESK2 -0.46 -5.15 -0.3 4.97e-7 Platelet count; CESC cis rs71403859 0.502 rs35981926 chr16:71500755 A/T cg08717414 chr16:71523259 ZNF19 -1.07 -9.15 -0.49 1.6e-17 Post bronchodilator FEV1; CESC cis rs2072732 0.861 rs12408197 chr1:2951511 C/T cg03976712 chr1:2946727 NA 0.33 5.45 0.32 1.17e-7 Plateletcrit; CESC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.6 -0.33 5.4e-8 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04189705 chr9:77502517 TRPM6 -0.55 -7.18 -0.4 6.9e-12 Gut microbiome composition (summer); CESC cis rs858239 0.539 rs2141306 chr7:23191664 G/A cg23682824 chr7:23144976 KLHL7 0.51 6.77 0.38 8.05e-11 Cerebrospinal fluid biomarker levels; CESC cis rs959260 1.000 rs4789184 chr17:73383314 A/G cg12999837 chr17:73267436 MIF4GD -0.48 -5.58 -0.32 5.89e-8 Systemic lupus erythematosus; CESC cis rs9581857 0.725 rs9581853 chr13:28016236 T/C cg01674679 chr13:27998804 GTF3A -0.69 -5.52 -0.32 7.89e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs4242434 0.889 rs11783129 chr8:22453426 G/A cg03733263 chr8:22462867 KIAA1967 0.89 14.47 0.66 2.37e-35 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16143763 chr17:41116517 AARSD1 -0.49 -6.46 -0.37 5.03e-10 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26428032 chr11:67387935 NA 0.43 7.08 0.4 1.3e-11 Fibrinogen levels; CESC cis rs17431357 1.000 rs14017 chr12:120941444 T/C cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Tonsillectomy; CESC cis rs35306767 0.904 rs35667562 chr10:950630 G/A cg26597838 chr10:835615 NA 1.16 11.23 0.57 3.36e-24 Eosinophil percentage of granulocytes; CESC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg04267008 chr7:1944627 MAD1L1 -0.75 -10.01 -0.52 3.22e-20 Bipolar disorder and schizophrenia; CESC cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg26597838 chr10:835615 NA 0.9 9.51 0.5 1.2e-18 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21036766 chr6:112683796 NA -0.53 -6.23 -0.36 1.86e-9 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -10.93 -0.56 3.43e-23 Extrinsic epigenetic age acceleration; CESC cis rs7707921 0.752 rs2406910 chr5:81308719 C/T cg15871215 chr5:81402204 ATG10 0.47 6.67 0.38 1.5e-10 Breast cancer; CESC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg17372223 chr3:52568218 NT5DC2 0.44 6.62 0.38 1.95e-10 Bipolar disorder; CESC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg12419862 chr22:24373484 LOC391322 0.85 10.3 0.53 3.72e-21 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs2742234 0.541 rs1879310 chr10:43734775 A/G cg07801480 chr10:43725741 RASGEF1A -0.41 -5.39 -0.31 1.58e-7 Hirschsprung disease; CESC cis rs7666738 0.546 rs2098935 chr4:98914376 A/G cg05340658 chr4:99064831 C4orf37 0.6 7.49 0.42 1.06e-12 Colonoscopy-negative controls vs population controls; CESC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.68 -8.71 -0.47 3.44e-16 Mean platelet volume; CESC cis rs1046896 0.520 rs9895409 chr17:80902719 C/T cg19046167 chr17:80928561 B3GNTL1 0.55 6.73 0.38 1.04e-10 Glycated hemoglobin levels; CESC cis rs12530845 1.000 rs6979391 chr7:135328873 C/T cg23117316 chr7:135346802 PL-5283 -0.41 -5.29 -0.31 2.52e-7 Red blood cell traits; CESC cis rs11098499 0.954 rs6848389 chr4:120402622 A/G cg09307838 chr4:120376055 NA 0.93 12.91 0.62 6.5e-30 Corneal astigmatism; CESC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg21951975 chr1:209979733 IRF6 0.58 7.22 0.41 5.67e-12 Cleft lip with or without cleft palate; CESC cis rs709400 0.930 rs61996717 chr14:104048571 T/C cg24130564 chr14:104152367 KLC1 -0.43 -5.07 -0.3 7.4e-7 Body mass index; CESC cis rs9796 0.558 rs7166905 chr15:41514876 G/C cg18705301 chr15:41695430 NDUFAF1 -0.47 -7.09 -0.4 1.2e-11 Menopause (age at onset); CESC cis rs13095912 0.719 rs7625483 chr3:185297113 T/C cg11274856 chr3:185301563 NA 0.4 6.09 0.35 4.01e-9 Systolic blood pressure; CESC cis rs12142240 0.660 rs72890715 chr1:46852077 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.3 0.45 5.19e-15 Menopause (age at onset); CESC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg07507251 chr3:52567010 NT5DC2 0.32 5.57 0.32 6.34e-8 Bipolar disorder; CESC cis rs2228479 0.618 rs34689166 chr16:89860697 C/T cg06558623 chr16:89946397 TCF25 1.18 9.47 0.5 1.65e-18 Skin colour saturation; CESC cis rs17490626 0.568 rs12413525 chr10:71211721 C/A cg12610070 chr10:71211762 TSPAN15 -0.32 -6.91 -0.39 3.55e-11 Thrombosis; CESC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.62 0.38 2.04e-10 Bipolar disorder; CESC cis rs1832871 0.672 rs9456295 chr6:158772078 G/A cg07165851 chr6:158734300 TULP4 0.58 6.19 0.36 2.31e-9 Height; CESC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg11890956 chr21:40555474 PSMG1 1.18 23.93 0.83 3.5e-68 Cognitive function; CESC cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg05347473 chr6:146136440 FBXO30 0.57 7.26 0.41 4.21e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02847760 chr15:40453199 BUB1B -0.49 -6.23 -0.36 1.81e-9 Ulcerative colitis; CESC cis rs6430585 0.583 rs61253125 chr2:136618178 T/C cg07169764 chr2:136633963 MCM6 1.29 19.97 0.78 9.47e-55 Corneal structure; CESC cis rs1577917 1.000 rs12192992 chr6:86609915 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -5.9 -0.34 1.13e-8 Response to antipsychotic treatment; CESC cis rs2404602 0.716 rs7174953 chr15:76906847 A/C cg22467129 chr15:76604101 ETFA -0.36 -5.28 -0.31 2.7e-7 Blood metabolite levels; CESC cis rs1018836 0.828 rs4734250 chr8:91591239 C/G cg16814680 chr8:91681699 NA 0.66 9.79 0.52 1.56e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7607369 0.714 rs55900247 chr2:219618708 T/C cg02176678 chr2:219576539 TTLL4 -0.5 -8.59 -0.47 7.43e-16 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs12822507 0.868 rs12580006 chr12:12789646 C/T cg09462578 chr12:12878428 APOLD1 -0.44 -5.62 -0.33 4.73e-8 Systemic lupus erythematosus; CESC cis rs933688 0.938 rs7708782 chr5:90718517 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.98 11.78 0.59 5.05e-26 Smoking behavior; CESC cis rs7771547 0.573 rs546353 chr6:36398597 C/A cg07856975 chr6:36356162 ETV7 0.36 5.38 0.31 1.67e-7 Platelet distribution width; CESC cis rs909002 0.586 rs2297684 chr1:32146764 A/G cg13919466 chr1:32135498 COL16A1 0.33 5.55 0.32 6.97e-8 Intelligence (multi-trait analysis); CESC cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.6e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19343861 chr12:123481935 PITPNM2 0.48 6.32 0.36 1.09e-9 Fibrinogen levels; CESC cis rs854765 0.583 rs9890341 chr17:17823175 G/C cg16928487 chr17:17741425 SREBF1 -0.57 -9.74 -0.51 2.41e-19 Total body bone mineral density; CESC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.32 0.36 1.13e-9 Bipolar disorder; CESC cis rs854765 0.583 rs4414547 chr17:17859052 G/T cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC trans rs1814175 0.650 rs6486000 chr11:49659090 T/A cg15704280 chr7:45808275 SEPT13 -0.98 -15.6 -0.69 2.26e-39 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06397424 chr16:15737279 NDE1;KIAA0430 -0.47 -6.34 -0.36 9.72e-10 Gut microbiota (bacterial taxa); CESC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg11644478 chr21:40555479 PSMG1 1.02 16.09 0.7 4.04e-41 Cognitive function; CESC cis rs77741769 0.571 rs73415720 chr12:121344515 T/C cg02419362 chr12:121203948 SPPL3 0.35 5.6 0.33 5.35e-8 Mean corpuscular volume; CESC cis rs4664308 0.935 rs58354887 chr2:160927112 C/T cg03641300 chr2:160917029 PLA2R1 -0.67 -9.79 -0.52 1.61e-19 Idiopathic membranous nephropathy; CESC cis rs7246657 0.943 rs9304566 chr19:37845504 T/C cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs4450798 0.649 rs73137996 chr3:13771796 C/A cg23332027 chr3:13681764 NA 0.38 5.21 0.3 3.81e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg00784671 chr22:46762841 CELSR1 -0.48 -5.61 -0.33 5.12e-8 LDL cholesterol;Cholesterol, total; CESC cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -9.51 -0.5 1.19e-18 Extrinsic epigenetic age acceleration; CESC cis rs2708240 0.936 rs4140925 chr7:147578597 G/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.78 -0.33 2.12e-8 QT interval (drug interaction); CESC trans rs7944735 0.545 rs4752805 chr11:48018355 A/G cg03929089 chr4:120376271 NA 0.56 6.43 0.37 5.85e-10 Intraocular pressure; CESC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.81 0.43 1.33e-13 Prudent dietary pattern; CESC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg02475777 chr4:1388615 CRIPAK 0.71 8.64 0.47 5.57e-16 Longevity; CESC cis rs7818345 0.967 rs7004435 chr8:19282732 G/A cg11303988 chr8:19266685 CSGALNACT1 0.33 5.83 0.34 1.58e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs3820068 0.580 rs12760698 chr1:16009814 G/A cg17385448 chr1:15911702 AGMAT 0.38 5.97 0.34 7.55e-9 Systolic blood pressure; CESC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg06634786 chr22:41940651 POLR3H -0.72 -7.6 -0.42 5.14e-13 Vitiligo; CESC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg11663144 chr21:46675770 NA -0.63 -10.04 -0.53 2.57e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs72781680 0.528 rs56258075 chr2:24104256 C/G cg08917208 chr2:24149416 ATAD2B 0.93 8.63 0.47 5.68e-16 Lymphocyte counts; CESC cis rs897984 0.762 rs4889604 chr16:30985994 G/T cg00531865 chr16:30841666 NA 0.5 6.8 0.39 6.84e-11 Dementia with Lewy bodies; CESC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.08e-20 Prudent dietary pattern; CESC cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg05340658 chr4:99064831 C4orf37 0.6 7.91 0.44 6.96e-14 Colonoscopy-negative controls vs population controls; CESC cis rs7918232 0.941 rs788210 chr10:27476948 T/C cg14442939 chr10:27389572 ANKRD26 -0.66 -6.44 -0.37 5.58e-10 Breast cancer; CESC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg07936489 chr17:37558343 FBXL20 -0.78 -11.15 -0.57 6.4e-24 Glomerular filtration rate (creatinine); CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg09177884 chr7:1199841 ZFAND2A -0.55 -6.16 -0.35 2.67e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs478304 0.651 rs948493 chr11:65552154 C/T cg27068330 chr11:65405492 SIPA1 -0.48 -5.76 -0.33 2.32e-8 Acne (severe); CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg12419862 chr22:24373484 LOC391322 -0.84 -12.38 -0.61 4.49e-28 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14400389 chr17:73201327 NUP85 0.45 6.09 0.35 3.95e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2645424 0.519 rs17154027 chr8:11713852 C/T cg21281001 chr8:11725306 CTSB -0.45 -5.51 -0.32 8.29e-8 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); CESC cis rs12477438 0.834 rs1563106 chr2:99701381 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -9.91 -0.52 6.61e-20 Chronic sinus infection; CESC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg27266027 chr21:40555129 PSMG1 0.45 5.13 0.3 5.52e-7 Cognitive function; CESC cis rs796364 0.951 rs971232 chr2:200792881 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.87 8.72 0.47 3.16e-16 Schizophrenia; CESC cis rs2932538 0.922 rs34531155 chr1:113141550 C/T cg22162597 chr1:113214053 CAPZA1 0.6 7.36 0.41 2.33e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg24250549 chr1:154909240 PMVK -0.63 -8.8 -0.48 1.84e-16 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15340270 chr11:62420901 INTS5 -0.64 -7.66 -0.43 3.48e-13 Gut microbiome composition (summer); CESC cis rs7546094 1.000 rs1001494 chr1:113110619 T/C cg22162597 chr1:113214053 CAPZA1 0.37 5.67 0.33 3.69e-8 Platelet distribution width; CESC cis rs2832077 0.527 rs2705690 chr21:30239245 T/A cg03476357 chr21:30257390 N6AMT1 0.48 6.05 0.35 5.02e-9 Cognitive test performance; CESC cis rs72945132 1.000 rs72945127 chr11:70107650 A/G cg00319359 chr11:70116639 PPFIA1 0.82 7.94 0.44 5.65e-14 Coronary artery disease; CESC cis rs10129255 0.500 rs59939897 chr14:107191651 A/G cg23076370 chr14:107095027 NA -0.65 -9.59 -0.51 6.94e-19 Kawasaki disease; CESC cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg20135002 chr11:47629003 NA -0.39 -5.03 -0.3 9.04e-7 Subjective well-being; CESC cis rs1185460 0.967 rs1784459 chr11:118938388 C/A cg01677386 chr11:118938358 VPS11 -0.44 -5.6 -0.33 5.29e-8 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05093860 chr3:132441075 NPHP3;NCRNA00119 0.54 6.93 0.39 3.15e-11 Gut microbiota (bacterial taxa); CESC cis rs9486719 1.000 rs2205755 chr6:96864704 A/G cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs8072100 0.727 rs4794052 chr17:45769236 T/C cg08085267 chr17:45401833 C17orf57 -0.43 -5.43 -0.32 1.27e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs4810685 0.526 rs6018685 chr20:46410809 A/G cg08288986 chr20:46415360 SULF2 -0.47 -5.37 -0.31 1.71e-7 Attention deficit hyperactivity disorder (time to onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23039201 chr2:27851887 GPN1;CCDC121 -0.51 -6.84 -0.39 5.44e-11 Ulcerative colitis; CESC cis rs10883723 0.810 rs7912901 chr10:104277440 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.18 0.3 4.34e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs4588572 0.688 rs4590164 chr5:77671870 A/G cg11547950 chr5:77652471 NA -0.39 -5.47 -0.32 1.05e-7 Triglycerides; CESC cis rs9443645 0.527 rs2105143 chr6:79742947 G/A cg05283184 chr6:79620031 NA -0.38 -5.48 -0.32 1.01e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.648 rs33988750 chr4:98985386 T/C cg03676636 chr4:99064102 C4orf37 0.41 5.11 0.3 6.23e-7 Colonoscopy-negative controls vs population controls; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg26084319 chr14:21905280 CHD8 -0.51 -6.82 -0.39 6e-11 Height; CESC cis rs3768617 0.811 rs4366285 chr1:183013672 T/G ch.1.3577855R chr1:183094577 LAMC1 0.65 8.89 0.48 9.94e-17 Fuchs's corneal dystrophy; CESC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg11764359 chr7:65958608 NA -0.78 -11.17 -0.57 5.37e-24 Aortic root size; CESC cis rs6974235 0.806 rs42073 chr7:95713880 G/A cg21022364 chr7:95948586 SLC25A13 0.37 5.35 0.31 1.92e-7 Total body bone mineral density; CESC cis rs10927875 0.550 rs12121918 chr1:16183556 C/A cg21385522 chr1:16154831 NA -0.92 -10.54 -0.54 6.39e-22 Dilated cardiomyopathy; CESC cis rs8060686 0.668 rs8046355 chr16:68205214 T/A cg26727032 chr16:67993705 SLC12A4 -0.56 -7.64 -0.42 4.1e-13 HDL cholesterol;Metabolic syndrome; CESC cis rs2019216 0.564 rs1518053 chr17:21924272 G/T cg22648282 chr17:21454238 C17orf51 -0.43 -5.67 -0.33 3.72e-8 Pelvic organ prolapse; CESC cis rs611744 0.503 rs13282220 chr8:109263043 T/C cg21045802 chr8:109455806 TTC35 0.48 5.56 0.32 6.55e-8 Dupuytren's disease; CESC cis rs634534 0.622 rs501353 chr11:65739549 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 6.44 0.37 5.64e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC trans rs877282 1.000 rs11253367 chr10:773389 G/A cg22713356 chr15:30763199 NA 1.11 11.3 0.57 2e-24 Uric acid levels; CESC cis rs2197308 0.765 rs7295711 chr12:37903631 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.76 0.38 8.79e-11 Morning vs. evening chronotype; CESC cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg10523679 chr1:76189770 ACADM 0.71 9.2 0.49 1.13e-17 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7116495 0.609 rs6592447 chr11:71641093 A/T cg26138937 chr11:71823887 C11orf51 -1.23 -8.55 -0.47 9.86e-16 Severe influenza A (H1N1) infection; CESC cis rs6912958 0.605 rs2754247 chr6:88383571 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.52 -6.91 -0.39 3.62e-11 Monocyte percentage of white cells; CESC trans rs1728785 0.901 rs3087783 chr16:68599668 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.71 8.43 0.46 2.17e-15 Ulcerative colitis; CESC cis rs2573652 0.722 rs968412 chr15:100544512 C/G cg00587665 chr15:100533223 ADAMTS17 -0.33 -5.22 -0.31 3.56e-7 Height; CESC cis rs9300255 0.739 rs1533703 chr12:123742093 T/G cg19016782 chr12:123741754 C12orf65 -0.48 -6.9 -0.39 3.71e-11 Neutrophil percentage of white cells; CESC cis rs453301 0.624 rs6987558 chr8:8862521 C/G cg06636001 chr8:8085503 FLJ10661 0.41 5.43 0.32 1.26e-7 Joint mobility (Beighton score); CESC cis rs34779708 0.966 rs4934734 chr10:35434373 T/C cg04310649 chr10:35416472 CREM -0.51 -6.14 -0.35 3.02e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7116495 0.867 rs510925 chr11:71809500 C/T cg26138937 chr11:71823887 C11orf51 1.22 7.84 0.43 1.12e-13 Severe influenza A (H1N1) infection; CESC cis rs7760535 0.656 rs1883136 chr6:111907023 G/T cg22127309 chr6:111907043 TRAF3IP2 -0.51 -7.87 -0.44 8.94e-14 Metabolic traits; CESC cis rs10131894 0.611 rs175000 chr14:75436367 T/C cg11812906 chr14:75593930 NEK9 -0.66 -10.16 -0.53 1.08e-20 Coronary artery disease; CESC cis rs634534 0.561 rs14157 chr11:65769780 T/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.47 6.31 0.36 1.14e-9 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs4319547 0.695 rs4758666 chr12:122902840 C/T cg05707623 chr12:122985044 ZCCHC8 -0.49 -6.07 -0.35 4.4e-9 Body mass index; CESC cis rs2439831 0.850 rs16977798 chr15:44151948 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.47 0.42 1.19e-12 Lung cancer in ever smokers; CESC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg12373951 chr3:133503437 NA -0.43 -6.38 -0.36 7.8e-10 Iron status biomarkers; CESC cis rs1065852 0.526 rs1062753 chr22:42392811 G/A cg22189786 chr22:42395067 WBP2NL 0.44 5.47 0.32 1.03e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs7197653 0.586 rs55856208 chr16:68324210 A/T cg26727032 chr16:67993705 SLC12A4 -0.55 -5.39 -0.31 1.57e-7 Magnesium levels; CESC cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg20891283 chr12:69753455 YEATS4 0.91 15.03 0.68 2.41e-37 Blood protein levels; CESC cis rs6580649 1.000 rs7132668 chr12:48405860 C/T cg05342945 chr12:48394962 COL2A1 -0.56 -6.56 -0.37 2.79e-10 Lung cancer; CESC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg21951975 chr1:209979733 IRF6 0.62 7.75 0.43 2.01e-13 Cleft lip with or without cleft palate; CESC trans rs9354308 0.834 rs12212376 chr6:66598879 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.63 7.15 0.4 8.59e-12 Metabolite levels; CESC cis rs2718058 0.692 rs2718041 chr7:37783944 A/G cg15028436 chr7:37888078 TXNDC3 0.39 5.51 0.32 8.63e-8 Alzheimer's disease (late onset); CESC cis rs7937682 0.921 rs4534611 chr11:111440425 C/G cg09085632 chr11:111637200 PPP2R1B -0.89 -12.05 -0.6 5.72e-27 Primary sclerosing cholangitis; CESC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg10883421 chr6:151773342 RMND1;C6orf211 0.86 14.41 0.66 3.84e-35 Menarche (age at onset); CESC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg23281280 chr6:28129359 ZNF389 0.53 7.06 0.4 1.5e-11 Parkinson's disease; CESC cis rs12579753 0.833 rs12579530 chr12:82163930 A/C cg24719984 chr12:82153464 PPFIA2 -0.36 -5.25 -0.31 3.12e-7 Resting heart rate; CESC cis rs8070740 0.898 rs8074617 chr17:5323989 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.35 0.36 9.3e-10 Menopause (age at onset); CESC cis rs7312933 0.558 rs11181507 chr12:42844763 T/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.43 0.37 5.82e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg25447359 chr22:30790057 NA -0.45 -6.32 -0.36 1.12e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg18305652 chr10:134549665 INPP5A 0.49 7.22 0.41 5.53e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2637266 1.000 rs7896831 chr10:78366649 A/T cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg24308560 chr3:49941425 MST1R -0.64 -9.35 -0.5 3.91e-18 Intelligence (multi-trait analysis); CESC cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg25405998 chr7:65216604 CCT6P1 -0.48 -5.19 -0.3 4.24e-7 Aortic root size; CESC cis rs12681288 0.782 rs2123055 chr8:1029500 T/G cg15309053 chr8:964076 NA 0.37 5.82 0.34 1.68e-8 Schizophrenia; CESC cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg18512352 chr11:47633146 NA -0.51 -7.43 -0.42 1.46e-12 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20539961 chr2:106497812 NCK2 -0.58 -6.42 -0.37 6.34e-10 Gut microbiome composition (summer); CESC cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.94 0.34 8.86e-9 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06581840 chr11:113644397 ZW10 0.58 6.22 0.36 1.98e-9 Gut microbiome composition (summer); CESC cis rs16858210 0.874 rs10937153 chr3:183562925 A/G cg03417191 chr3:183542750 MAP6D1 0.44 5.66 0.33 3.97e-8 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04504578 chr17:36831313 C17orf96 0.43 5.99 0.35 6.68e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg06074448 chr4:187884817 NA 0.48 7.49 0.42 1.02e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9430161 0.579 rs11121667 chr1:11038476 C/T cg27631724 chr1:11040367 C1orf127 0.46 8.39 0.46 3.01e-15 Ewing sarcoma; CESC cis rs8092503 0.904 rs12606230 chr18:52492252 T/C cg12377874 chr18:52495404 RAB27B 0.37 6.13 0.35 3.13e-9 Childhood body mass index; CESC cis rs11168618 0.626 rs11609074 chr12:48819335 C/A cg24011408 chr12:48396354 COL2A1 0.36 5.53 0.32 7.49e-8 Adiponectin levels; CESC cis rs897080 0.552 rs1085442 chr2:44635454 C/A cg04920474 chr2:44395004 PPM1B 0.37 5.12 0.3 5.97e-7 Height; CESC cis rs3733585 0.673 rs4292332 chr4:9953830 C/A cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs710216 1.000 rs710216 chr1:43428757 A/G cg03128534 chr1:43423976 SLC2A1 0.54 6.36 0.36 8.78e-10 Red cell distribution width; CESC cis rs1707322 0.752 rs8179402 chr1:46142466 C/A cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6088580 0.634 rs6088475 chr20:32964987 T/C cg06115741 chr20:33292138 TP53INP2 -0.47 -6.02 -0.35 5.66e-9 Glomerular filtration rate (creatinine); CESC cis rs8017423 0.967 rs2282030 chr14:90730265 G/A cg14092571 chr14:90743983 NA -0.57 -8.53 -0.46 1.14e-15 Mortality in heart failure; CESC cis rs8077889 0.871 rs72836549 chr17:41904360 G/T cg26893861 chr17:41843967 DUSP3 0.83 9.9 0.52 7.45e-20 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04719420 chr1:183441464 SMG7 -0.54 -6.32 -0.36 1.11e-9 Gut microbiome composition (summer); CESC cis rs9815354 0.767 rs6805140 chr3:41995791 A/G cg03022575 chr3:42003672 ULK4 0.65 5.93 0.34 9.31e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg09359103 chr1:154839909 KCNN3 -0.66 -12.18 -0.6 2.2e-27 Prostate cancer; CESC cis rs6439153 0.933 rs9822511 chr3:128705567 G/A cg24203234 chr3:128598194 ACAD9 0.42 5.45 0.32 1.17e-7 Pneumococcal bacteremia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26313349 chr1:145589328 NUDT17 -0.42 -6.41 -0.37 6.77e-10 Gambling; CESC cis rs7208859 0.623 rs11657662 chr17:29076347 A/G cg13385521 chr17:29058706 SUZ12P -0.87 -6.66 -0.38 1.53e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11997175 0.574 rs10954931 chr8:33631066 A/T ch.8.33884649F chr8:33765107 NA 0.64 8.22 0.45 9.32e-15 Body mass index; CESC cis rs9715521 0.900 rs4860450 chr4:59827819 G/A cg11281224 chr4:60001000 NA -0.5 -6.57 -0.37 2.6200000000000003e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7208859 0.623 rs35916850 chr17:29011173 G/A cg13385521 chr17:29058706 SUZ12P 0.72 5.63 0.33 4.63e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9611565 0.921 rs761366 chr22:41744022 C/G cg06634786 chr22:41940651 POLR3H -0.63 -6.46 -0.37 5.02e-10 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20046119 chr8:145981207 ZNF251 -0.52 -6.24 -0.36 1.75e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27194998 chr19:47217554 PRKD2 0.66 7.55 0.42 7.25e-13 Gut microbiome composition (summer); CESC cis rs1707322 0.752 rs7541962 chr1:46235117 G/A cg06784218 chr1:46089804 CCDC17 0.39 6.84 0.39 5.31e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4664308 0.810 rs59019419 chr2:161061287 G/A cg03641300 chr2:160917029 PLA2R1 -0.63 -9.23 -0.49 8.91e-18 Idiopathic membranous nephropathy; CESC cis rs826838 0.616 rs7966266 chr12:38626138 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.65 -0.33 4.09e-8 Heart rate; CESC cis rs62432291 0.681 rs2932987 chr6:159655673 C/G cg14500486 chr6:159655392 FNDC1 0.6 6.31 0.36 1.18e-9 Joint mobility (Beighton score); CESC cis rs9303401 0.659 rs12944971 chr17:56988801 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.98 10.73 0.55 1.47e-22 Cognitive test performance; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24972377 chr12:122326574 PSMD9 0.61 7.27 0.41 3.95e-12 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.53 7.21 0.41 5.73e-12 Bipolar disorder; CESC cis rs36051895 0.664 rs3780370 chr9:5095167 A/C cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.61e-9 Pediatric autoimmune diseases; CESC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg16145915 chr7:1198662 ZFAND2A -0.63 -9.61 -0.51 6.08e-19 Longevity;Endometriosis; CESC cis rs35146811 0.771 rs1060544 chr7:99613476 C/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.49 6.06 0.35 4.59e-9 Coronary artery disease; CESC cis rs3815700 1.000 rs8104328 chr19:33094371 G/A cg02997394 chr19:33096574 ANKRD27 0.73 7.32 0.41 2.97e-12 Eosinophilic esophagitis; CESC cis rs17376456 0.825 rs17372615 chr5:93124768 C/T cg21475434 chr5:93447410 FAM172A 0.8 7.22 0.41 5.48e-12 Diabetic retinopathy; CESC cis rs4253772 0.832 rs6008259 chr22:46633782 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.57 6.51 0.37 3.7e-10 LDL cholesterol;Cholesterol, total; CESC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg02018176 chr4:1364513 KIAA1530 0.61 7.94 0.44 5.93e-14 Longevity; CESC cis rs4253772 0.744 rs4253760 chr22:46622384 T/G cg24881330 chr22:46731750 TRMU 0.64 6.45 0.37 5.33e-10 LDL cholesterol;Cholesterol, total; CESC cis rs57506017 0.585 rs13229988 chr7:12267837 A/G cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.58e-7 Neuroticism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12551462 chr6:153304904 FBXO5 -0.5 -6.28 -0.36 1.36e-9 Ulcerative colitis; CESC cis rs6484504 0.576 rs286649 chr11:31230468 C/T cg14844989 chr11:31128820 NA -0.42 -5.97 -0.34 7.57e-9 Red blood cell count; CESC cis rs9905704 0.914 rs2643120 chr17:56826949 A/T cg12560992 chr17:57184187 TRIM37 0.61 7.09 0.4 1.25e-11 Testicular germ cell tumor; CESC cis rs870825 0.616 rs28524599 chr4:185647414 A/G cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs9640161 0.830 rs6722 chr7:150068933 T/C cg21361702 chr7:150065534 REPIN1 0.49 6.48 0.37 4.5e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs941873 0.868 rs2181080 chr10:81121960 A/G cg09469691 chr10:81107165 PPIF 0.58 7.78 0.43 1.67e-13 Height; CESC cis rs3820068 0.581 rs16851819 chr1:15918739 C/T cg17385448 chr1:15911702 AGMAT -0.44 -7.26 -0.41 4.38e-12 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21623633 chr19:14492003 CD97 0.52 6.29 0.36 1.31e-9 Gut microbiome composition (summer); CESC cis rs7635838 0.785 rs2606738 chr3:11396562 T/C cg00170343 chr3:11313890 ATG7 0.49 6.89 0.39 4.1e-11 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07050772 chr17:48423262 XYLT2 0.56 6.8 0.39 6.74e-11 Gut microbiome composition (summer); CESC cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg06970220 chr1:156163860 SLC25A44 0.39 5.18 0.3 4.32e-7 Testicular germ cell tumor; CESC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.07 -0.3 7.39e-7 Total body bone mineral density; CESC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg22963979 chr7:1858916 MAD1L1 -0.43 -5.87 -0.34 1.31e-8 Bipolar disorder and schizophrenia; CESC cis rs6460942 0.597 rs17448193 chr7:12525641 G/A cg02935154 chr7:12443704 VWDE -0.55 -5.53 -0.32 7.71e-8 Coronary artery disease; CESC cis rs9611565 0.607 rs132792 chr22:42062822 C/T cg17376030 chr22:41985996 PMM1 -0.46 -5.39 -0.31 1.53e-7 Vitiligo; CESC cis rs4450798 0.793 rs28581168 chr3:13740488 A/C cg23332027 chr3:13681764 NA 0.4 5.36 0.31 1.81e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.59 0.32 5.58e-8 Bipolar disorder; CESC cis rs3540 0.597 rs12708583 chr15:91050271 C/T cg22089800 chr15:90895588 ZNF774 0.67 9.44 0.5 2.08e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1577917 0.739 rs9344532 chr6:86234070 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.56 7.53 0.42 8.17e-13 Response to antipsychotic treatment; CESC trans rs1814175 0.615 rs4545557 chr11:50027329 A/C cg15704280 chr7:45808275 SEPT13 -1.0 -18.54 -0.75 9.01e-50 Height; CESC cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg03433033 chr1:76189801 ACADM -0.67 -7.91 -0.44 7.05e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs793571 0.523 rs7161889 chr15:58983425 C/G cg05156742 chr15:59063176 FAM63B 0.58 7.77 0.43 1.74e-13 Schizophrenia; CESC cis rs1348850 0.958 rs4893965 chr2:178463852 G/T cg23306229 chr2:178417860 TTC30B 0.57 7.52 0.42 8.3e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs17293817 0.618 rs58703400 chr10:1430346 A/G cg04271617 chr10:1416546 ADARB2 0.34 5.27 0.31 2.9e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2742234 0.955 rs2435384 chr10:43673731 G/T cg15436174 chr10:43711423 RASGEF1A -0.42 -5.34 -0.31 2.01e-7 Hirschsprung disease; CESC trans rs7980799 0.772 rs6488162 chr12:33593127 T/C cg26384229 chr12:38710491 ALG10B -0.52 -6.85 -0.39 5.26e-11 Heart rate;Heart rate variability traits (RMSSD); CESC trans rs4129059 0.765 rs57047137 chr1:214708900 C/T cg08158662 chr12:34489995 NA 0.56 6.45 0.37 5.31e-10 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1915146 0.546 rs9422857 chr10:126861278 C/G cg17191109 chr10:126851326 NA 0.42 6.76 0.38 8.55e-11 Menarche (age at onset); CESC cis rs2070488 0.804 rs13092164 chr3:38458533 G/A cg24069376 chr3:38537580 EXOG 0.35 6.02 0.35 5.94e-9 Electrocardiographic conduction measures; CESC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -5.94 -0.34 8.89e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3008870 0.755 rs4486425 chr1:67460791 T/C cg02640540 chr1:67518911 SLC35D1 -0.46 -5.58 -0.32 5.81e-8 Lymphocyte percentage of white cells; CESC cis rs2074585 0.839 rs11638780 chr15:91041896 G/T cg10434728 chr15:90938212 IQGAP1 -0.42 -7.64 -0.42 4.06e-13 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs2573652 1.000 rs7163481 chr15:100516916 C/G cg00587665 chr15:100533223 ADAMTS17 0.32 5.03 0.3 9.08e-7 Height; CESC cis rs34779708 0.733 rs3936503 chr10:35549257 A/G cg04310649 chr10:35416472 CREM 0.45 5.31 0.31 2.32e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs9611565 0.592 rs5996039 chr22:41981957 A/G cg06481639 chr22:41940642 POLR3H -0.56 -6.32 -0.36 1.13e-9 Vitiligo; CESC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg26343298 chr8:95960752 TP53INP1 0.36 5.96 0.34 7.8e-9 Type 2 diabetes; CESC cis rs7208859 0.623 rs73269913 chr17:29092183 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6693567 0.545 rs2012751 chr1:150438266 T/C cg09579323 chr1:150459698 TARS2 0.48 6.08 0.35 4.13e-9 Migraine; CESC cis rs1864400 0.645 rs2249005 chr10:43627280 A/G cg15436174 chr10:43711423 RASGEF1A -0.49 -5.6 -0.33 5.32e-8 Hirschsprung disease; CESC cis rs7149337 0.805 rs7146561 chr14:51608889 C/G cg23942311 chr14:51606299 NA 0.48 8.36 0.46 3.56e-15 Cancer; CESC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg06028808 chr11:68637592 NA 0.45 5.31 0.31 2.37e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9486719 0.947 rs11153071 chr6:97039741 G/A cg06623918 chr6:96969491 KIAA0776 -0.79 -8.13 -0.45 1.64e-14 Migraine;Coronary artery disease; CESC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg00784671 chr22:46762841 CELSR1 -0.48 -5.59 -0.32 5.72e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9815354 0.672 rs12107296 chr3:41892503 C/G cg03022575 chr3:42003672 ULK4 0.45 5.2 0.3 3.99e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs4253772 0.591 rs9615935 chr22:46686115 T/G cg24881330 chr22:46731750 TRMU 0.75 5.43 0.32 1.25e-7 LDL cholesterol;Cholesterol, total; CESC cis rs11997175 0.655 rs72630923 chr8:33662404 C/A ch.8.33884649F chr8:33765107 NA 0.47 5.96 0.34 7.88e-9 Body mass index; CESC cis rs9457247 1.000 rs416131 chr6:167406544 A/C cg07741184 chr6:167504864 NA -0.32 -5.73 -0.33 2.66e-8 Crohn's disease; CESC trans rs9467711 0.659 rs66941101 chr6:26530376 C/T cg06606381 chr12:133084897 FBRSL1 -0.93 -7.16 -0.4 8.07e-12 Autism spectrum disorder or schizophrenia; CESC cis rs2072499 0.750 rs10159384 chr1:156160822 C/T cg24450063 chr1:156163899 SLC25A44 0.98 11.99 0.59 9.64e-27 Testicular germ cell tumor; CESC cis rs6540559 0.543 rs664097 chr1:210422179 C/T cg21951975 chr1:209979733 IRF6 0.46 6.18 0.35 2.41e-9 Cleft lip with or without cleft palate; CESC cis rs763121 0.785 rs6001203 chr22:39099602 T/C cg06022373 chr22:39101656 GTPBP1 0.94 17.4 0.73 9.39e-46 Menopause (age at onset); CESC cis rs939658 0.805 rs11631590 chr15:79446199 C/T cg17916960 chr15:79447300 NA -0.36 -5.83 -0.34 1.65e-8 Refractive error; CESC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21962918 chr5:134094454 DDX46 0.59 6.8 0.39 6.91e-11 Gut microbiome composition (summer); CESC cis rs6546537 0.911 rs13027712 chr2:69891367 C/T cg10773587 chr2:69614142 GFPT1 -0.59 -6.86 -0.39 4.74e-11 Serum thyroid-stimulating hormone levels; CESC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg24881330 chr22:46731750 TRMU 0.86 7.93 0.44 6.15e-14 LDL cholesterol;Cholesterol, total; CESC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg04944784 chr2:26401820 FAM59B -0.75 -8.97 -0.48 5.69e-17 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20593868 chr20:62588672 UCKL1;ZNF512B -0.38 -6.34 -0.36 1.01e-9 Gambling; CESC cis rs8177253 0.665 rs8177178 chr3:133463272 G/A cg24879335 chr3:133465180 TF 0.31 5.22 0.31 3.63e-7 Iron status biomarkers; CESC cis rs9309473 1.000 rs13383871 chr2:73631779 T/C cg20560298 chr2:73613845 ALMS1 -0.53 -6.93 -0.39 3.18e-11 Metabolite levels; CESC cis rs936229 0.705 rs936227 chr15:75131959 A/G cg14664628 chr15:75095509 CSK -0.57 -7.51 -0.42 8.83e-13 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs989128 0.600 rs73338243 chr17:48631324 T/C cg24438145 chr17:48624694 SPATA20 0.45 5.31 0.31 2.36e-7 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08072980 chr7:50450320 IKZF1 -0.42 -6.15 -0.35 2.88e-9 Gut microbiota (bacterial taxa); CESC cis rs9815354 0.680 rs73075204 chr3:42030392 G/A cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg27535305 chr1:53392650 SCP2 -0.31 -5.35 -0.31 1.89e-7 Monocyte count; CESC trans rs11039798 0.920 rs9667596 chr11:48691193 T/C cg15704280 chr7:45808275 SEPT13 0.7 6.42 0.37 6.38e-10 Axial length; CESC cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg02551604 chr5:131831745 NA -0.37 -5.27 -0.31 2.81e-7 Asthma (sex interaction); CESC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg27266027 chr21:40555129 PSMG1 0.43 5.15 0.3 5.06e-7 Cognitive function; CESC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg22467129 chr15:76604101 ETFA -0.39 -6.02 -0.35 5.84e-9 Blood metabolite levels; CESC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.51 6.31 0.36 1.13e-9 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10557320 chr6:12012551 HIVEP1 -0.52 -6.14 -0.35 2.96e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.21 0.31 3.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg18876405 chr7:65276391 NA 0.48 6.31 0.36 1.16e-9 Aortic root size; CESC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg24531977 chr5:56204891 C5orf35 -0.47 -5.87 -0.34 1.29e-8 Coronary artery disease; CESC cis rs453301 0.686 rs6748 chr8:8890802 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -6.19 -0.36 2.27e-9 Joint mobility (Beighton score); CESC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg15445000 chr17:37608096 MED1 -0.42 -6.66 -0.38 1.57e-10 Glomerular filtration rate (creatinine); CESC cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg22875332 chr1:76189707 ACADM 0.63 7.34 0.41 2.59e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9584850 0.874 rs7988959 chr13:99104004 T/C cg20750642 chr13:99100586 FARP1 -0.4 -6.02 -0.35 5.73e-9 Neuroticism; CESC cis rs2637266 0.935 rs2252661 chr10:78404793 A/G cg18941641 chr10:78392320 NA 0.45 8.65 0.47 4.94e-16 Pulmonary function; CESC cis rs12979813 0.901 rs10421795 chr19:11344406 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.38 5.31 0.31 2.27e-7 HDL cholesterol; CESC cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.48 0.32 1.01e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs12142240 0.660 rs112560929 chr1:46822297 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs6831352 0.819 rs1154401 chr4:100009738 G/C cg21548116 chr4:100009993 ADH5 0.46 5.19 0.3 4.27e-7 Alcohol dependence; CESC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg11890956 chr21:40555474 PSMG1 1.2 22.3 0.81 9.49e-63 Cognitive function; CESC cis rs3820928 0.874 rs12467261 chr2:227888838 T/C cg11843606 chr2:227700838 RHBDD1 -0.47 -6.25 -0.36 1.66e-9 Pulmonary function; CESC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg18357526 chr6:26021779 HIST1H4A -0.4 -5.97 -0.34 7.65e-9 Blood metabolite levels; CESC cis rs6991838 0.584 rs11985628 chr8:66542739 T/C cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs2228479 0.702 rs2074903 chr16:89811663 T/C cg04013166 chr16:89971882 TCF25 0.79 6.78 0.38 7.83e-11 Skin colour saturation; CESC cis rs6541297 0.703 rs652108 chr1:230312704 C/T cg20703242 chr1:230279135 GALNT2 -0.43 -5.59 -0.32 5.66e-8 Coronary artery disease; CESC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg14926445 chr8:58193284 C8orf71 -0.5 -5.38 -0.31 1.62e-7 Developmental language disorder (linguistic errors); CESC cis rs12325245 0.536 rs3169293 chr16:58552959 A/G cg01152986 chr16:58549298 SETD6 0.89 5.38 0.31 1.62e-7 Schizophrenia; CESC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg27266060 chr8:22091797 NA 0.38 7.81 0.43 1.33e-13 Hypertriglyceridemia; CESC cis rs4728302 0.934 rs4129572 chr7:133636888 T/C cg10665199 chr7:133106180 EXOC4 -0.37 -5.04 -0.3 8.52e-7 Intelligence;Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04127825 chr1:167503222 NA -0.46 -6.77 -0.38 8.44e-11 Gambling; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg15433164 chr3:25824899 NGLY1 0.39 6.33 0.36 1.02e-9 Vertical cup-disc ratio; CESC cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg08564027 chr20:61660810 NA 0.9 15.37 0.69 1.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs12369635 0.929 rs3851667 chr12:129550552 G/T cg01909103 chr12:129572610 TMEM132D 0.67 6.1 0.35 3.73e-9 Schizophrenia (inflammation and infection response interaction); CESC cis rs2072732 0.861 rs67872056 chr1:2954165 C/T cg03976712 chr1:2946727 NA 0.33 5.53 0.32 7.83e-8 Plateletcrit; CESC cis rs2425143 1.000 rs2425149 chr20:34359587 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.73 6.75 0.38 9.36e-11 Blood protein levels; CESC cis rs3820068 0.562 rs10927841 chr1:16045261 T/C cg17385448 chr1:15911702 AGMAT 0.38 5.95 0.34 8.35e-9 Systolic blood pressure; CESC cis rs116095464 0.558 rs2288459 chr5:231143 T/C cg10591111 chr5:226296 SDHA -0.51 -6.18 -0.35 2.44e-9 Breast cancer; CESC cis rs1348850 0.608 rs10176632 chr2:178225934 G/T cg22681709 chr2:178499509 PDE11A -0.36 -5.33 -0.31 2.12e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.45 0.32 1.15e-7 Bipolar disorder; CESC cis rs7274811 0.625 rs293734 chr20:31924680 T/A cg21523528 chr20:32077966 CBFA2T2 -0.5 -5.62 -0.33 4.71e-8 Height; CESC cis rs2455799 0.574 rs2102212 chr3:15704223 C/T cg16303742 chr3:15540471 COLQ -0.42 -6.58 -0.37 2.48e-10 Mean platelet volume; CESC cis rs12477438 0.501 rs12619780 chr2:99707307 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.85 0.62 1.04e-29 Chronic sinus infection; CESC cis rs7659604 0.521 rs4833235 chr4:122695136 C/A cg19671926 chr4:122722719 EXOSC9 0.64 8.55 0.46 1.02e-15 Type 2 diabetes; CESC cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg23711669 chr6:146136114 FBXO30 0.97 14.72 0.67 3.09e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs7107174 0.681 rs881337 chr11:78128335 G/C cg02023728 chr11:77925099 USP35 0.43 5.48 0.32 1.01e-7 Testicular germ cell tumor; CESC cis rs7944584 0.545 rs7118178 chr11:47659135 G/A cg20307385 chr11:47447363 PSMC3 0.8 11.09 0.56 9.91e-24 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs3733585 0.588 rs6449154 chr4:9956404 C/T cg00071950 chr4:10020882 SLC2A9 -0.7 -11.52 -0.58 3.7e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg09491104 chr22:46646882 C22orf40 -0.49 -5.89 -0.34 1.14e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9291683 0.546 rs6820188 chr4:10051655 C/T cg11266682 chr4:10021025 SLC2A9 0.64 12.67 0.61 4.55e-29 Bone mineral density; CESC cis rs910316 1.000 rs10146482 chr14:75574087 C/T cg08847533 chr14:75593920 NEK9 1.02 20.98 0.79 2.94e-58 Height; CESC cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg02551604 chr5:131831745 NA -0.37 -5.27 -0.31 2.81e-7 Asthma (sex interaction); CESC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg23803603 chr1:2058230 PRKCZ -0.38 -6.9 -0.39 3.81e-11 Height; CESC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs7914558 1.000 rs11191539 chr10:104819770 A/G cg08650961 chr10:104748594 CNNM2 0.31 5.19 0.3 4.18e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg22920501 chr2:26401640 FAM59B -0.7 -8.4 -0.46 2.77e-15 Gut microbiome composition (summer); CESC cis rs739496 0.542 rs7306529 chr12:111780644 A/G cg10833066 chr12:111807467 FAM109A 0.34 5.24 0.31 3.34e-7 Platelet count; CESC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC trans rs9929218 0.551 rs2274240 chr16:68725486 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.97 16.37 0.71 4.18e-42 Colorectal cancer; CESC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg13206674 chr6:150067644 NUP43 0.39 5.5 0.32 9.04e-8 Lung cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09926380 chr3:10052611 LOC401052 0.42 6.27 0.36 1.45e-9 Asthma; CESC cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg21573476 chr21:45109991 RRP1B -0.58 -8.44 -0.46 2.17e-15 Mean corpuscular volume; CESC cis rs763014 0.865 rs710924 chr16:633353 T/C cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC trans rs7395662 0.591 rs4882012 chr11:48560597 T/A cg00717180 chr2:96193071 NA -0.45 -6.19 -0.36 2.32e-9 HDL cholesterol; CESC cis rs3733585 0.631 rs3822236 chr4:10119961 T/G cg11266682 chr4:10021025 SLC2A9 -0.55 -10.3 -0.53 3.87e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9291683 0.530 rs11723970 chr4:9980462 T/C cg02734326 chr4:10020555 SLC2A9 0.46 6.92 0.39 3.38e-11 Bone mineral density; CESC cis rs41271473 0.519 rs9660783 chr1:228886880 C/T cg00850481 chr1:228891306 NA -0.46 -6.19 -0.36 2.32e-9 Chronic lymphocytic leukemia; CESC cis rs1878931 0.597 rs37816 chr16:3456371 G/A cg02880119 chr16:3481970 NA 0.43 5.32 0.31 2.24e-7 Body mass index (adult); CESC cis rs9300255 0.543 rs1260294 chr12:123560289 T/C cg00376283 chr12:123451042 ABCB9 -0.69 -7.14 -0.4 8.92e-12 Neutrophil percentage of white cells; CESC trans rs1814175 0.587 rs7948538 chr11:50021353 A/C cg15704280 chr7:45808275 SEPT13 -1.0 -18.53 -0.75 9.55e-50 Height; CESC cis rs7818688 0.932 rs6471506 chr8:96028700 T/C cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7605827 0.930 rs6718736 chr2:15525875 C/T cg19274914 chr2:15703543 NA 0.36 6.45 0.37 5.37e-10 Educational attainment (years of education); CESC cis rs7523050 0.643 rs12736534 chr1:109399934 T/C cg08274380 chr1:109419600 GPSM2 0.83 5.58 0.32 5.89e-8 Fat distribution (HIV); CESC trans rs7849270 1.000 rs10819469 chr9:131882067 G/T cg05583848 chr6:35265411 DEF6 -0.44 -6.06 -0.35 4.54e-9 Blood metabolite ratios; CESC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg18876405 chr7:65276391 NA 0.56 7.48 0.42 1.1e-12 Aortic root size; CESC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.94 10.67 0.55 2.43e-22 Platelet count; CESC cis rs1451375 0.652 rs7803440 chr7:50625632 C/T cg14593290 chr7:50529359 DDC 0.44 5.37 0.31 1.71e-7 Malaria; CESC cis rs6912958 0.967 rs6905947 chr6:88161949 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.61 -8.44 -0.46 2.16e-15 Monocyte percentage of white cells; CESC cis rs12477438 0.765 rs1115756 chr2:99659845 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs11203032 0.831 rs9651424 chr10:90932935 A/G cg16672925 chr10:90967113 CH25H 0.69 6.48 0.37 4.53e-10 Heart failure; CESC cis rs6088590 0.687 rs6088580 chr20:33285053 G/C cg24642439 chr20:33292090 TP53INP2 0.68 9.04 0.49 3.51e-17 Coronary artery disease; CESC cis rs637571 0.522 rs606978 chr11:65711517 A/C cg04055107 chr11:65626734 MUS81;CFL1 0.43 5.27 0.31 2.89e-7 Eosinophil percentage of white cells; CESC cis rs17376456 0.877 rs17083460 chr5:93462354 A/G cg25358565 chr5:93447407 FAM172A 1.15 11.8 0.59 4.11e-26 Diabetic retinopathy; CESC trans rs427691 0.625 rs845740 chr5:109018902 C/T cg00054525 chr16:88717587 CYBA -0.61 -6.33 -0.36 1.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs684232 0.583 rs17677436 chr17:520314 T/C cg12384639 chr17:618140 VPS53 0.43 5.46 0.32 1.12e-7 Prostate cancer; CESC cis rs2963155 0.590 rs258757 chr5:142620736 A/G cg17617527 chr5:142782415 NR3C1 -0.78 -7.25 -0.41 4.67e-12 Breast cancer; CESC cis rs7851660 0.967 rs12348304 chr9:100611233 T/C cg13688889 chr9:100608707 NA -0.68 -10.64 -0.55 3.08e-22 Strep throat; CESC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs6500395 1.000 rs11644518 chr16:48616789 A/G cg04672837 chr16:48644449 N4BP1 0.51 6.5 0.37 3.95e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9487051 0.621 rs351721 chr6:109551109 G/T cg01475377 chr6:109611718 NA -0.38 -5.14 -0.3 5.22e-7 Reticulocyte fraction of red cells; CESC cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.92 0.34 1.01e-8 Tonsillectomy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21271961 chr1:95285780 SLC44A3 0.48 6.2 0.36 2.2e-9 Gut microbiota (bacterial taxa); CESC cis rs7336332 0.598 rs75439483 chr13:28010512 A/G cg22138327 chr13:27999177 GTF3A 0.62 5.82 0.34 1.71e-8 Weight; CESC cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg22875332 chr1:76189707 ACADM 0.62 6.31 0.36 1.17e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg08847533 chr14:75593920 NEK9 0.99 18.38 0.75 3.34e-49 Height; CESC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg07648498 chr16:89883185 FANCA 0.44 5.56 0.32 6.73e-8 Vitiligo; CESC trans rs4824093 0.610 rs4824113 chr22:50284974 C/T cg09872104 chr7:134855509 C7orf49 -0.94 -6.17 -0.35 2.52e-9 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6460942 1.000 rs6970095 chr7:12403840 G/A cg06484146 chr7:12443880 VWDE -0.7 -8.15 -0.45 1.5e-14 Coronary artery disease; CESC cis rs8014204 0.544 rs2286913 chr14:75386576 G/A cg26191576 chr14:75389716 RPS6KL1 -0.39 -5.5 -0.32 8.89e-8 Caffeine consumption; CESC cis rs7580658 0.613 rs12463538 chr2:128196854 G/T cg10021288 chr2:128175891 PROC -0.4 -5.93 -0.34 9.32e-9 Protein C levels; CESC cis rs10791323 0.569 rs1944734 chr11:133720077 G/A cg15485101 chr11:133734466 NA 0.36 5.8 0.34 1.89e-8 Childhood ear infection; CESC cis rs6887276 0.504 rs1003136 chr5:127347815 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.4 5.04 0.3 8.54e-7 Height; CESC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg06420487 chr17:61919686 SMARCD2 0.46 5.53 0.32 7.63e-8 Height; CESC cis rs4835473 0.932 rs34257944 chr4:144657596 A/G cg25736465 chr4:144833511 NA -0.33 -5.2 -0.3 3.99e-7 Immature fraction of reticulocytes; CESC cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg12386194 chr3:101231763 SENP7 0.45 5.52 0.32 8.09e-8 Colorectal cancer; CESC cis rs9549260 0.755 rs9566553 chr13:41174231 A/G cg21288729 chr13:41239152 FOXO1 0.61 7.67 0.43 3.32e-13 Red blood cell count; CESC cis rs4253772 0.591 rs739165 chr22:46684528 C/T cg18190219 chr22:46762943 CELSR1 -0.59 -5.61 -0.33 5.16e-8 LDL cholesterol;Cholesterol, total; CESC cis rs763121 0.853 rs6001182 chr22:39047443 A/G cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC cis rs2652822 0.509 rs7163254 chr15:63439403 G/T cg02713581 chr15:63449717 RPS27L 0.51 5.61 0.33 4.98e-8 Metabolic traits; CESC cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg20476274 chr7:133979776 SLC35B4 0.6 8.33 0.46 4.39e-15 Mean platelet volume; CESC cis rs950776 0.593 rs6495306 chr15:78865893 C/T cg24631222 chr15:78858424 CHRNA5 0.43 5.41 0.32 1.4e-7 Sudden cardiac arrest; CESC cis rs9549367 0.713 rs3024746 chr13:113821777 G/A cg00898013 chr13:113819073 PROZ -0.49 -6.96 -0.39 2.69e-11 Platelet distribution width; CESC cis rs11638352 1.000 rs11854312 chr15:44279709 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.63 -5.6 -0.33 5.48e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg10351095 chr21:47802916 PCNT -0.43 -5.75 -0.33 2.48e-8 Testicular germ cell tumor; CESC cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -7.55 -0.42 6.89e-13 Personality dimensions; CESC cis rs9611565 0.649 rs202625 chr22:41827082 G/A cg03806693 chr22:41940476 POLR3H 1.2 14.53 0.67 1.4e-35 Vitiligo; CESC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 12.2 0.6 1.88e-27 Platelet count; CESC cis rs3092073 0.624 rs11696196 chr20:44574533 C/T cg00125455 chr20:44574271 PCIF1 0.38 5.96 0.34 8.15e-9 Intelligence (multi-trait analysis); CESC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.7 -0.33 3.17e-8 Total body bone mineral density; CESC cis rs67311347 1.000 rs17078916 chr3:40445438 C/T cg09455208 chr3:40491958 NA 0.52 8.59 0.47 7.51e-16 Renal cell carcinoma; CESC cis rs8018808 0.905 rs11159259 chr14:77892393 C/T cg20045696 chr14:77926864 AHSA1 0.42 5.84 0.34 1.55e-8 Myeloid white cell count; CESC cis rs10918270 1.000 rs3795649 chr1:161931562 G/A cg19735514 chr1:161762739 ATF6 -0.35 -5.19 -0.3 4.16e-7 Parkinson's disease (age of onset); CESC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19742111 chr11:66460113 SPTBN2 -0.62 -7.04 -0.4 1.61e-11 Gut microbiome composition (summer); CESC cis rs9814567 1.000 rs4368544 chr3:134300014 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.06 0.35 4.58e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9549260 0.753 rs9549254 chr13:41234763 G/A cg21288729 chr13:41239152 FOXO1 0.55 5.4 0.31 1.49e-7 Red blood cell count; CESC cis rs28374715 0.532 rs7164211 chr15:41705041 A/T cg02330683 chr15:41787940 ITPKA 0.44 5.44 0.32 1.2e-7 Ulcerative colitis; CESC cis rs7000551 0.751 rs2449340 chr8:22389900 T/G cg12081754 chr8:22256438 SLC39A14 0.41 5.54 0.32 7.46e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs3820068 0.580 rs34426856 chr1:16006315 C/T cg13390004 chr1:15929781 NA 0.34 5.18 0.3 4.33e-7 Systolic blood pressure; CESC cis rs7940866 0.809 rs11222410 chr11:130833994 A/G cg12179176 chr11:130786555 SNX19 0.62 8.55 0.47 9.71e-16 Schizophrenia; CESC cis rs7520050 0.902 rs4626927 chr1:46248645 C/T cg24296786 chr1:45957014 TESK2 0.44 5.57 0.32 6.14e-8 Red blood cell count;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17079530 chr11:117014700 PAFAH1B2 -0.63 -7.44 -0.42 1.43e-12 Gut microbiome composition (summer); CESC cis rs1983170 0.736 rs4484968 chr1:92012005 C/A cg02896835 chr1:92012615 NA 0.59 6.22 0.36 1.88e-9 Eosinophil percentage of white cells; CESC trans rs11971186 1.000 rs12534101 chr7:126419412 C/A cg10894441 chr11:111169905 C11orf92;C11orf93 0.47 5.99 0.35 6.66e-9 Chemerin levels; CESC cis rs17376456 0.877 rs10040648 chr5:93490301 G/C cg21475434 chr5:93447410 FAM172A 0.85 7.58 0.42 5.88e-13 Diabetic retinopathy; CESC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg14393609 chr7:65229607 NA 0.47 6.29 0.36 1.29e-9 Calcium levels; CESC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.29e-7 Life satisfaction; CESC cis rs7188697 0.922 rs37039 chr16:58578091 C/T cg21335942 chr16:58549945 SETD6 0.46 5.48 0.32 1.01e-7 QT interval; CESC cis rs9814567 0.806 rs4535271 chr3:134321669 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.39 -5.13 -0.3 5.64e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs11039798 0.623 rs594615 chr11:48402804 T/C cg15704280 chr7:45808275 SEPT13 -0.69 -6.75 -0.38 9.03e-11 Axial length; CESC cis rs4975616 0.869 rs380286 chr5:1320247 G/A cg07493874 chr5:1342172 CLPTM1L -0.41 -7.75 -0.43 2.03e-13 Lung cancer; CESC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg23978390 chr7:1156363 C7orf50 0.64 8.91 0.48 8.43e-17 Longevity;Endometriosis; CESC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.42 -0.37 6.1e-10 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05678175 chr19:59056626 TRIM28 -0.56 -6.36 -0.36 8.78e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22586474 chr7:931148 C7orf20 0.5 6.82 0.39 6.04e-11 Fibrinogen levels; CESC cis rs7264396 0.790 rs3787166 chr20:34229072 A/T cg23207816 chr20:34252616 CPNE1;RBM12 0.55 5.64 0.33 4.26e-8 Total cholesterol levels; CESC cis rs72945132 0.882 rs56368190 chr11:70204328 T/G cg00319359 chr11:70116639 PPFIA1 0.73 6.96 0.39 2.63e-11 Coronary artery disease; CESC trans rs35110281 0.807 rs4818850 chr21:45028071 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 6.52 0.37 3.47e-10 Mean corpuscular volume; CESC cis rs2932538 0.922 rs6698030 chr1:113138318 G/A cg22162597 chr1:113214053 CAPZA1 0.6 7.33 0.41 2.75e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs10911232 0.507 rs4129857 chr1:183004547 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 13.48 0.64 6.62e-32 Hypertriglyceridemia; CESC trans rs2055011 1.000 rs1491784 chr21:19481664 C/T cg21339533 chr7:23221367 NUPL2 -0.53 -6.25 -0.36 1.68e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CESC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.86 -9.71 -0.51 2.82e-19 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07089834 chr17:79239572 SLC38A10 -0.66 -7.54 -0.42 7.55e-13 Gut microbiome composition (summer); CESC cis rs11958404 0.932 rs72816584 chr5:157433190 G/A cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs6137287 0.574 rs11696663 chr20:21065004 C/T cg13880779 chr20:21376337 NKX2-4 0.33 5.13 0.3 5.47e-7 Height; CESC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg07507251 chr3:52567010 NT5DC2 0.41 7.17 0.4 7.64e-12 Bipolar disorder; CESC cis rs8114671 0.586 rs6087634 chr20:33413809 G/A cg07148914 chr20:33460835 GGT7 0.42 5.29 0.31 2.63e-7 Height; CESC cis rs6662572 1.000 rs11587982 chr1:46161868 A/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 5.46 0.32 1.1e-7 Blood protein levels; CESC cis rs2439831 0.681 rs2242067 chr15:43699303 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.76 9.29 0.5 5.64e-18 Lung cancer in ever smokers; CESC trans rs9951602 0.512 rs8084836 chr18:76647841 A/G cg02800362 chr5:177631904 HNRNPAB 0.63 8.4 0.46 2.7e-15 Obesity-related traits; CESC cis rs1595825 0.891 rs6733834 chr2:198518709 C/G cg00982548 chr2:198649783 BOLL 0.47 5.03 0.3 9.03e-7 Ulcerative colitis; CESC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg23758822 chr17:41437982 NA -1.02 -15.85 -0.7 2.99e-40 Menopause (age at onset); CESC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg18230493 chr5:56204884 C5orf35 -0.66 -8.28 -0.45 6.32e-15 Initial pursuit acceleration; CESC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg17372223 chr3:52568218 NT5DC2 0.4 5.94 0.34 8.86e-9 Electroencephalogram traits; CESC cis rs7617773 0.539 rs13069884 chr3:48381148 T/A cg11946769 chr3:48343235 NME6 0.66 8.34 0.46 4.12e-15 Coronary artery disease; CESC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg04414720 chr1:150670196 GOLPH3L 0.62 8.8 0.48 1.76e-16 Tonsillectomy; CESC cis rs1538970 0.962 rs3219472 chr1:45804050 A/G cg05343316 chr1:45956843 TESK2 -0.83 -10.41 -0.54 1.72e-21 Platelet count; CESC cis rs7833986 0.534 rs2667972 chr8:56906661 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.09 0.4 1.2e-11 Height; CESC cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg05347473 chr6:146136440 FBXO30 0.72 8.95 0.48 6.27e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs66887589 0.967 rs7678973 chr4:120511817 T/C cg09307838 chr4:120376055 NA -0.53 -7.07 -0.4 1.35e-11 Diastolic blood pressure; CESC cis rs2197308 0.765 rs12370231 chr12:37917881 T/C cg13010199 chr12:38710504 ALG10B 0.54 6.81 0.39 6.5e-11 Morning vs. evening chronotype; CESC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg03806693 chr22:41940476 POLR3H -1.14 -13.12 -0.63 1.26e-30 Crohn's disease;Inflammatory bowel disease; CESC cis rs60843830 1.000 rs10193373 chr2:281886 T/G cg25945732 chr2:264204 ACP1;SH3YL1 0.87 11.49 0.58 4.68e-25 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9788682 0.747 rs2915695 chr15:78739471 T/C cg24631222 chr15:78858424 CHRNA5 -0.63 -7.51 -0.42 9.21e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs56804039 0.895 rs11776995 chr8:8385547 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -5.42 -0.32 1.35e-7 Cervical cancer; CESC cis rs12134245 0.747 rs11164929 chr1:92012836 G/C cg25838465 chr1:92012736 NA -0.64 -10.07 -0.53 2.12e-20 Breast cancer; CESC trans rs8056446 0.710 rs8059793 chr16:78189298 A/C cg05022673 chr6:56819429 DST;BEND6 0.46 6.12 0.35 3.44e-9 Pulmonary function (smoking interaction); CESC cis rs1788820 0.717 rs1788823 chr18:21114917 A/G cg14672496 chr18:21087552 C18orf8 0.43 5.86 0.34 1.37e-8 Body mass index; CESC cis rs367615 0.918 rs10067984 chr5:108872684 C/T cg17395555 chr5:108820864 NA 0.55 8.2 0.45 1.06e-14 Colorectal cancer (SNP x SNP interaction); CESC cis rs796364 0.806 rs6435040 chr2:200861161 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.83 7.49 0.42 1e-12 Schizophrenia; CESC cis rs4423214 1.000 rs12419279 chr11:71139061 T/A cg05163923 chr11:71159392 DHCR7 0.78 10.47 0.54 1.04e-21 Vitamin D levels; CESC cis rs67311347 1.000 rs2085115 chr3:40497540 G/T cg24209194 chr3:40518798 ZNF619 0.51 6.07 0.35 4.48e-9 Renal cell carcinoma; CESC cis rs7116495 1.000 rs4945426 chr11:71748146 A/C cg26138937 chr11:71823887 C11orf51 0.79 6.88 0.39 4.3e-11 Severe influenza A (H1N1) infection; CESC cis rs9399135 0.967 rs2327578 chr6:135329969 C/T cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs6088580 0.634 rs6142157 chr20:32984172 C/G cg08999081 chr20:33150536 PIGU -0.64 -11.25 -0.57 2.81e-24 Glomerular filtration rate (creatinine); CESC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg12412775 chr1:25698385 RHCE -0.33 -5.97 -0.34 7.79e-9 Erythrocyte sedimentation rate; CESC cis rs3733418 0.860 rs35449092 chr4:165949676 C/G cg10852876 chr4:165953100 TRIM60 -0.47 -5.5 -0.32 8.73e-8 Obesity-related traits; CESC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg11890956 chr21:40555474 PSMG1 1.17 21.83 0.8 3.83e-61 Cognitive function; CESC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg14393609 chr7:65229607 NA -0.45 -6.02 -0.35 5.91e-9 Aortic root size; CESC cis rs2730245 1.000 rs2252502 chr7:158738634 G/C cg24397884 chr7:158709396 WDR60 -0.89 -13.66 -0.64 1.65e-32 Height; CESC cis rs1707322 0.716 rs6694889 chr1:46101806 A/C cg03146154 chr1:46216737 IPP 0.81 11.48 0.58 5.05e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1538970 0.961 rs7543428 chr1:45839643 A/G cg05343316 chr1:45956843 TESK2 0.84 11.83 0.59 3.26e-26 Platelet count; CESC trans rs2573652 0.755 rs1469830 chr15:100517403 G/T cg02378063 chr4:22913868 NA -0.38 -6.0 -0.35 6.28e-9 Height; CESC cis rs360798 0.532 rs12713468 chr2:62983213 G/A cg17519650 chr2:63277830 OTX1 -0.59 -7.61 -0.42 4.72e-13 Coronary artery disease; CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg18099408 chr3:52552593 STAB1 -0.43 -8.03 -0.44 3.23e-14 Electroencephalogram traits; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23712980 chr20:30795555 POFUT1;PLAGL2 -0.49 -6.61 -0.38 2.15e-10 Asthma; CESC cis rs10465746 0.725 rs10127737 chr1:84368642 G/A cg10977910 chr1:84465055 TTLL7 0.56 7.74 0.43 2.07e-13 Obesity-related traits; CESC trans rs11989744 0.500 rs7844903 chr8:23568464 T/C cg03492747 chr16:86543808 FOXF1 -0.85 -13.64 -0.64 1.83e-32 Waist-hip ratio; CESC cis rs4141404 0.582 rs5753630 chr22:31861950 A/G cg00478049 chr22:31556069 RNF185 -0.41 -5.06 -0.3 8.02e-7 Paclitaxel-induced neuropathy; CESC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg19717773 chr7:2847554 GNA12 -0.46 -6.47 -0.37 4.83e-10 Height; CESC cis rs4561483 0.801 rs251723 chr16:11953080 G/C cg08843971 chr16:11963173 GSPT1 -0.56 -8.06 -0.44 2.56e-14 Testicular germ cell tumor; CESC cis rs2273669 0.510 rs11757590 chr6:109370003 T/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC trans rs28735056 0.572 rs4799100 chr18:77640207 A/G cg05926928 chr17:57297772 GDPD1 -0.62 -7.71 -0.43 2.55e-13 Schizophrenia; CESC cis rs9900062 0.560 rs11656678 chr17:62681505 G/A cg02097616 chr17:62675921 NA 0.44 5.51 0.32 8.34e-8 QT interval; CESC cis rs7173419 0.607 rs12915936 chr15:28223836 A/G cg20906524 chr15:28200668 OCA2 -0.38 -5.21 -0.31 3.72e-7 Eye color; CESC trans rs524281 0.731 rs12576969 chr11:65802478 A/G cg03887094 chr16:67198826 HSF4 0.51 6.02 0.35 5.82e-9 Electroencephalogram traits; CESC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg23048001 chr7:2026167 MAD1L1 0.45 5.79 0.33 2.02e-8 Bipolar disorder and schizophrenia; CESC cis rs9625935 0.518 rs5752972 chr22:30250312 A/T cg01021169 chr22:30184971 ASCC2 0.4 6.31 0.36 1.19e-9 Tonsillectomy; CESC cis rs2463822 0.614 rs117699706 chr11:62161659 T/C cg06239285 chr11:62104954 ASRGL1 -1.07 -9.26 -0.49 7.43e-18 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs36051895 0.589 rs62543573 chr9:5201675 A/G cg02405213 chr9:5042618 JAK2 -0.53 -6.18 -0.35 2.45e-9 Pediatric autoimmune diseases; CESC trans rs526821 0.595 rs517627 chr11:55356489 C/T cg03929089 chr4:120376271 NA -0.5 -6.07 -0.35 4.33e-9 Pediatric bone mineral density (spine); CESC cis rs8077577 0.747 rs11868708 chr17:18244613 T/C cg16794390 chr17:18148240 FLII 0.41 6.38 0.36 8.03e-10 Obesity-related traits; CESC cis rs870825 0.655 rs28604350 chr4:185638723 G/A cg04058563 chr4:185651563 MLF1IP 0.63 6.93 0.39 3.17e-11 Blood protein levels; CESC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.623 rs7212991 chr17:29143749 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3768617 0.510 rs12078729 chr1:183060072 T/A ch.1.3577855R chr1:183094577 LAMC1 0.88 13.97 0.65 1.34e-33 Fuchs's corneal dystrophy; CESC cis rs7267979 0.873 rs6132822 chr20:25228695 C/T cg08601574 chr20:25228251 PYGB 0.42 5.81 0.34 1.82e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs6500395 0.963 rs6500405 chr16:48690486 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.54 -5.73 -0.33 2.72e-8 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24173921 chr3:44690229 ZNF35 -0.51 -6.5 -0.37 4.01e-10 Ulcerative colitis; CESC cis rs2342371 0.565 rs11185543 chr3:196215660 G/A cg15048948 chr3:196158458 UBXN7 -0.39 -5.36 -0.31 1.81e-7 Fat distribution (HIV); CESC cis rs7927771 0.524 rs12362318 chr11:47682671 T/C cg18512352 chr11:47633146 NA 0.34 5.21 0.31 3.73e-7 Subjective well-being; CESC cis rs1348850 0.958 rs4528793 chr2:178464271 C/T cg23306229 chr2:178417860 TTC30B 0.57 7.52 0.42 8.3e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6942756 0.806 rs10257620 chr7:128901429 C/A cg02491457 chr7:128862824 NA 0.65 9.65 0.51 4.39e-19 White matter hyperintensity burden; CESC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg07701084 chr6:150067640 NUP43 0.43 5.95 0.34 8.47e-9 Lung cancer; CESC cis rs6121246 0.559 rs6121243 chr20:30415094 C/G cg13852791 chr20:30311386 BCL2L1 0.85 11.11 0.56 8.34e-24 Mean corpuscular hemoglobin; CESC cis rs7635838 0.617 rs346074 chr3:11294310 T/C cg00170343 chr3:11313890 ATG7 0.59 8.61 0.47 6.6e-16 HDL cholesterol; CESC cis rs12586317 0.576 rs10130047 chr14:35633580 C/A cg16230307 chr14:35515116 FAM177A1 0.4 5.09 0.3 6.79e-7 Psoriasis; CESC cis rs9790314 1.000 rs336579 chr3:161086610 G/A cg03342759 chr3:160939853 NMD3 -0.44 -5.61 -0.33 5.11e-8 Morning vs. evening chronotype; CESC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.03e-9 Aortic root size; CESC cis rs3806843 0.771 rs2563334 chr5:140107065 C/G cg26395211 chr5:140044315 WDR55 0.47 5.95 0.34 8.5e-9 Depressive symptoms (multi-trait analysis); CESC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg25985355 chr7:65971099 NA 0.31 5.11 0.3 6.09e-7 Aortic root size; CESC cis rs6740322 0.748 rs6544636 chr2:43487486 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.8 -8.73 -0.47 2.84e-16 Coronary artery disease; CESC cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg10523679 chr1:76189770 ACADM -0.58 -6.0 -0.35 6.31e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg17372223 chr3:52568218 NT5DC2 0.44 6.56 0.37 2.88e-10 Bipolar disorder; CESC cis rs300703 0.515 rs300695 chr2:182644 C/A cg21211680 chr2:198530 NA -0.91 -10.69 -0.55 2.11e-22 Blood protein levels; CESC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg22143856 chr6:28129313 ZNF389 0.44 5.83 0.34 1.57e-8 Depression; CESC cis rs929596 0.561 rs6431625 chr2:234637912 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.62 -8.34 -0.46 4.2e-15 Total bilirubin levels in HIV-1 infection; CESC cis rs55728055 0.661 rs12165609 chr22:32036332 T/C cg01338084 chr22:32026380 PISD 1.21 8.55 0.47 9.91e-16 Age-related hearing impairment; CESC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.59 7.71 0.43 2.62e-13 Menopause (age at onset); CESC cis rs1707322 0.721 rs6697821 chr1:46216722 A/G cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs6136813 0.556 rs66649546 chr20:19656150 C/T cg10180406 chr1:186649877 PTGS2 0.61 6.01 0.35 6.15e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg24101359 chr6:42928495 GNMT 0.59 9.13 0.49 1.84e-17 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg22800045 chr5:56110881 MAP3K1 0.59 7.69 0.43 2.8e-13 Initial pursuit acceleration; CESC cis rs2652822 0.967 rs4775633 chr15:63437746 G/A cg02713581 chr15:63449717 RPS27L 0.59 7.71 0.43 2.49e-13 Metabolic traits; CESC cis rs7116495 0.609 rs7942626 chr11:71703849 G/A cg10381502 chr11:71823885 C11orf51 -1.16 -7.94 -0.44 5.77e-14 Severe influenza A (H1N1) infection; CESC cis rs4423214 1.000 rs12793530 chr11:71161656 G/A cg05163923 chr11:71159392 DHCR7 0.76 10.35 0.54 2.66e-21 Vitamin D levels; CESC cis rs3820928 0.605 rs4281898 chr2:227855493 A/C cg11843606 chr2:227700838 RHBDD1 -0.5 -6.92 -0.39 3.44e-11 Pulmonary function; CESC cis rs6120849 0.754 rs6120828 chr20:33674460 A/G cg24642439 chr20:33292090 TP53INP2 0.64 6.48 0.37 4.38e-10 Protein C levels; CESC cis rs10899021 1.000 rs61900636 chr11:74359591 G/T cg25880958 chr11:74394337 NA -0.76 -7.25 -0.41 4.55e-12 Response to metformin (IC50); CESC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.66 -7.47 -0.42 1.15e-12 Gut microbiome composition (summer); CESC cis rs643506 0.874 rs582465 chr11:111668585 C/T cg09085632 chr11:111637200 PPP2R1B 0.39 5.12 0.3 5.9e-7 Breast cancer; CESC cis rs11168351 0.864 rs12228750 chr12:48496997 G/A cg24011408 chr12:48396354 COL2A1 -0.5 -7.58 -0.42 5.74e-13 Bipolar disorder and schizophrenia; CESC cis rs7267979 0.934 rs2261753 chr20:25262291 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.21e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs1152591 0.811 rs1255984 chr14:64654431 C/T cg21174375 chr14:64681225 SYNE2 -0.47 -6.31 -0.36 1.17e-9 Atrial fibrillation; CESC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg00149659 chr3:10157352 C3orf10 0.76 9.49 0.5 1.4e-18 Alzheimer's disease; CESC cis rs910316 0.737 rs175072 chr14:75502827 T/C cg08847533 chr14:75593920 NEK9 -0.91 -16.32 -0.71 6.26e-42 Height; CESC cis rs2072732 0.861 rs12409277 chr1:2957600 A/G cg03976712 chr1:2946727 NA 0.32 5.55 0.32 7.06e-8 Plateletcrit; CESC cis rs17293817 0.589 rs34788429 chr10:1422208 A/G cg04271617 chr10:1416546 ADARB2 0.35 5.48 0.32 1e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg16489826 chr6:160211363 TCP1;MRPL18 0.73 8.91 0.48 8.29e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.94e-9 Extrinsic epigenetic age acceleration; CESC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.34 -5.45 -0.32 1.17e-7 Cystic fibrosis severity; CESC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg13880726 chr7:1868755 MAD1L1 0.53 7.11 0.4 1.08e-11 Bipolar disorder and schizophrenia; CESC cis rs6594499 0.872 rs10043631 chr5:110443228 C/T cg04022379 chr5:110408740 TSLP 0.33 5.9 0.34 1.1e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs6582630 0.537 rs35336822 chr12:38346251 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.81 0.34 1.75e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs3820928 0.874 rs10199655 chr2:227892428 T/C cg11843606 chr2:227700838 RHBDD1 -0.48 -6.4 -0.37 7.05e-10 Pulmonary function; CESC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg08968635 chr6:28129556 ZNF389 0.33 5.04 0.3 8.57e-7 Cardiac Troponin-T levels; CESC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg22143856 chr6:28129313 ZNF389 0.46 5.83 0.34 1.58e-8 Depression; CESC cis rs4891159 0.790 rs11872411 chr18:74132051 C/T cg24786174 chr18:74118243 ZNF516 -0.76 -12.06 -0.6 5.35e-27 Longevity; CESC cis rs13385 0.769 rs722437 chr5:139545729 A/T cg26211634 chr5:139558579 C5orf32 0.47 5.16 0.3 4.77e-7 Atrial fibrillation; CESC cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg16339924 chr4:17578868 LAP3 0.51 6.57 0.37 2.67e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7582720 1.000 rs72934765 chr2:203758551 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.4 0.41 1.85e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg10351095 chr21:47802916 PCNT 0.43 5.55 0.32 7.02e-8 Testicular germ cell tumor; CESC cis rs4409675 0.576 rs12062621 chr1:28230404 A/G cg23691781 chr1:28212827 C1orf38 0.28 5.65 0.33 4.16e-8 Corneal astigmatism; CESC trans rs10841784 0.958 rs7962263 chr12:21466117 A/G cg19907483 chr19:6040198 RFX2 0.5 6.35 0.36 9.44e-10 Childhood ear infection; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09516144 chr16:15982637 C16orf63 -0.5 -6.2 -0.36 2.1e-9 Ulcerative colitis; CESC cis rs4253772 0.550 rs739164 chr22:46684558 C/T cg24881330 chr22:46731750 TRMU -0.84 -8.92 -0.48 7.58e-17 LDL cholesterol;Cholesterol, total; CESC cis rs1953600 0.837 rs2819946 chr10:81951635 G/A cg00277334 chr10:82204260 NA 0.45 6.26 0.36 1.56e-9 Sarcoidosis; CESC trans rs1545843 0.564 rs2446669 chr12:84888478 G/T cg03015433 chr16:56623111 MT3 0.34 6.04 0.35 5.19e-9 Major depressive disorder; CESC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg06221963 chr1:154839813 KCNN3 -0.65 -10.78 -0.55 1.09e-22 Prostate cancer; CESC cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg24308560 chr3:49941425 MST1R -0.64 -9.19 -0.49 1.17e-17 Intelligence (multi-trait analysis); CESC cis rs4006360 0.524 rs6503601 chr17:39280487 A/C cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.43 -5.42 -0.32 1.36e-7 Bipolar disorder and schizophrenia; CESC cis rs916888 0.821 rs199509 chr17:44858728 G/A cg15921436 chr17:44337874 NA -0.7 -7.95 -0.44 5.35e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg22920501 chr2:26401640 FAM59B -0.64 -7.75 -0.43 2.03e-13 Gut microbiome composition (summer); CESC cis rs6570726 0.818 rs952405 chr6:145925952 T/C cg23711669 chr6:146136114 FBXO30 0.83 12.33 0.6 6.39e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs4700695 0.640 rs27083 chr5:65435865 C/T cg21114390 chr5:65439923 SFRS12 -0.49 -5.88 -0.34 1.21e-8 Facial morphology (factor 19); CESC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg11663144 chr21:46675770 NA -0.49 -7.59 -0.42 5.62e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9457247 0.565 rs2239824 chr6:167511799 T/A cg23791538 chr6:167370224 RNASET2 -0.53 -6.98 -0.39 2.32e-11 Crohn's disease; CESC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg06808227 chr14:105710500 BRF1 -0.56 -6.33 -0.36 1.04e-9 Mean platelet volume;Platelet distribution width; CESC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 11.48 0.58 4.99e-25 Platelet count; CESC cis rs5758659 0.652 rs133324 chr22:42406371 C/A cg04733989 chr22:42467013 NAGA 0.44 5.86 0.34 1.37e-8 Cognitive function; CESC cis rs7174348 1 rs7174348 chr15:78792439 G/A cg24631222 chr15:78858424 CHRNA5 0.63 7.48 0.42 1.07e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs2204008 0.744 rs11495519 chr12:38060546 C/A cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs67478160 0.643 rs3742369 chr14:104251276 T/C cg01849466 chr14:104193079 ZFYVE21 -0.5 -6.96 -0.39 2.72e-11 Schizophrenia; CESC cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg20503657 chr10:835505 NA 0.78 7.74 0.43 2.14e-13 Eosinophil percentage of granulocytes; CESC cis rs2718058 0.519 rs2598054 chr7:37884640 C/T cg15028436 chr7:37888078 TXNDC3 0.52 7.38 0.41 2.01e-12 Alzheimer's disease (late onset); CESC cis rs854765 0.547 rs8069811 chr17:17922280 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.55 7.83 0.43 1.16e-13 Total body bone mineral density; CESC cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg06212747 chr3:49208901 KLHDC8B 0.71 9.31 0.5 4.93e-18 Parkinson's disease; CESC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg18252515 chr7:66147081 NA 0.4 5.14 0.3 5.38e-7 Aortic root size; CESC cis rs11083475 0.557 rs2368519 chr19:39259241 C/T cg07905965 chr19:39260460 NA 0.46 7.25 0.41 4.68e-12 Heart rate; CESC cis rs4654899 1.000 rs4654899 chr1:21410231 G/T cg05370193 chr1:21551575 ECE1 0.38 5.79 0.34 1.97e-8 Superior frontal gyrus grey matter volume; CESC cis rs9486715 0.867 rs4240553 chr6:96965324 T/C cg06623918 chr6:96969491 KIAA0776 0.95 14.61 0.67 7.22e-36 Headache; CESC cis rs1538970 0.924 rs1007858 chr1:45912005 C/T cg06784218 chr1:46089804 CCDC17 0.35 5.54 0.32 7.26e-8 Platelet count; CESC cis rs18122 0.781 rs2156717 chr2:67616977 A/T cg09028215 chr2:67624308 ETAA1 -0.46 -5.55 -0.32 6.91e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs244293 0.965 rs2214980 chr17:53207061 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.09 -0.3 6.87e-7 Menarche (age at onset); CESC cis rs1559088 0.948 rs10408093 chr19:33597816 T/C cg27124370 chr19:33622961 WDR88 0.45 5.99 0.35 6.77e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs559928 0.606 rs56207008 chr11:63883215 C/T cg18225595 chr11:63971243 STIP1 0.63 5.66 0.33 4e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs12579753 0.719 rs4418885 chr12:82275845 A/T cg21193143 chr12:82153300 PPFIA2 -0.35 -5.35 -0.31 1.92e-7 Resting heart rate; CESC cis rs4901847 0.577 rs11158199 chr14:58585354 T/C cg15908186 chr14:58618357 C14orf37 0.34 5.13 0.3 5.61e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs2479724 0.905 rs2274578 chr6:41888827 C/G cg17623882 chr6:41773611 USP49 -0.41 -5.84 -0.34 1.5e-8 Menarche (age at onset); CESC cis rs763121 0.651 rs738249 chr22:39037979 T/C cg06022373 chr22:39101656 GTPBP1 0.86 13.01 0.62 3.03e-30 Menopause (age at onset); CESC cis rs703842 1.000 rs11172349 chr12:58212528 G/A cg00677455 chr12:58241039 CTDSP2 0.54 6.94 0.39 3.05e-11 Multiple sclerosis; CESC cis rs748404 0.723 rs573169 chr15:43550581 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.62 7.94 0.44 5.82e-14 Lung cancer; CESC cis rs7223966 1.000 rs11657081 chr17:61792339 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.36 0.41 2.27e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.58 0.61 9.12e-29 Colonoscopy-negative controls vs population controls; CESC cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg23711669 chr6:146136114 FBXO30 0.97 14.77 0.67 2.05e-36 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27150598 chr12:124325933 DNAH10 -0.51 -6.28 -0.36 1.4e-9 Gut microbiome composition (summer); CESC cis rs6594713 0.717 rs10065790 chr5:112911165 C/T cg12552261 chr5:112820674 MCC 0.57 5.55 0.32 6.94e-8 Brain cytoarchitecture; CESC cis rs9309473 0.851 rs6546850 chr2:73831147 A/T cg20560298 chr2:73613845 ALMS1 -0.45 -6.03 -0.35 5.44e-9 Metabolite levels; CESC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.03 -0.4 1.73e-11 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20430870 chr10:52487619 NA -0.63 -7.21 -0.4 5.79e-12 Gut microbiome composition (summer); CESC cis rs734999 0.545 rs9970196 chr1:2574078 T/C cg20673091 chr1:2541236 MMEL1 -0.49 -8.06 -0.44 2.61e-14 Ulcerative colitis; CESC cis rs9303401 0.614 rs12950028 chr17:56510140 A/G cg25039879 chr17:56429692 SUPT4H1 0.52 5.44 0.32 1.19e-7 Cognitive test performance; CESC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg07677032 chr17:61819896 STRADA 0.43 5.49 0.32 9.42e-8 Height; CESC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.66 9.09 0.49 2.43e-17 Menopause (age at onset); CESC cis rs1950626 0.699 rs12896504 chr14:101467948 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.84 -10.98 -0.56 2.37e-23 Pelvic organ prolapse (moderate/severe); CESC cis rs2735413 0.846 rs12923626 chr16:78080139 A/C cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.13e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs6693567 0.526 rs834239 chr1:150375458 C/A cg09579323 chr1:150459698 TARS2 0.48 6.01 0.35 6.23e-9 Migraine; CESC cis rs4253772 0.637 rs9627295 chr22:46650100 C/T cg24881330 chr22:46731750 TRMU 0.89 10.09 0.53 1.86e-20 LDL cholesterol;Cholesterol, total; CESC cis rs728616 0.614 rs56147535 chr10:82027625 G/T cg27171509 chr10:82033454 MAT1A -0.41 -5.05 -0.3 8.39e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs10779751 0.881 rs2744815 chr1:11360957 C/T cg08854313 chr1:11322531 MTOR 0.79 11.54 0.58 3.16e-25 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.8.1993893R chr8:98864783 LAPTM4B -0.55 -6.33 -0.36 1.02e-9 Gut microbiome composition (summer); CESC cis rs7259376 0.837 rs1368476 chr19:22586192 A/G cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.76e-7 Menopause (age at onset); CESC cis rs2243480 1.000 rs34703416 chr7:65300642 A/G cg13147721 chr7:65941812 NA -0.87 -8.59 -0.47 7.36e-16 Diabetic kidney disease; CESC cis rs6598163 0.517 rs10902453 chr12:132297091 G/T cg22244940 chr12:132335942 MMP17 -0.52 -7.06 -0.4 1.43e-11 Migraine; CESC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg06481639 chr22:41940642 POLR3H 0.59 5.84 0.34 1.51e-8 Vitiligo; CESC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg16545954 chr1:2118288 C1orf86 -0.34 -6.64 -0.38 1.73e-10 Height; CESC cis rs344364 0.511 rs1742473 chr16:1953095 T/C cg03013636 chr16:1946785 NA 0.47 6.37 0.36 8.23e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs698833 0.501 rs35347977 chr2:44506921 C/T cg04920474 chr2:44395004 PPM1B 0.48 6.88 0.39 4.37e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg02475777 chr4:1388615 CRIPAK 0.73 9.28 0.5 6.07e-18 Longevity; CESC cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg10523679 chr1:76189770 ACADM 0.72 8.33 0.46 4.31e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs13385 0.769 rs13175751 chr5:139601097 C/G cg26211634 chr5:139558579 C5orf32 0.46 5.12 0.3 5.97e-7 Atrial fibrillation; CESC cis rs3754214 0.857 rs9126 chr1:150259400 A/C cg09579323 chr1:150459698 TARS2 -0.44 -5.56 -0.32 6.43e-8 Cerebrospinal fluid biomarker levels; CESC cis rs4319547 0.656 rs6488951 chr12:122873928 A/G cg05707623 chr12:122985044 ZCCHC8 -0.54 -6.17 -0.35 2.48e-9 Body mass index; CESC cis rs10870270 0.784 rs10430614 chr10:133748640 C/T cg08754478 chr10:133766260 PPP2R2D 0.5 6.55 0.37 3.01e-10 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1975974 1.000 rs4889703 chr17:21721663 T/C cg18423549 chr17:21743878 NA -0.51 -7.02 -0.4 1.81e-11 Psoriasis; CESC cis rs2243480 1.000 rs34560516 chr7:65404092 A/T cg25894440 chr7:65020034 NA -0.62 -5.16 -0.3 4.73e-7 Diabetic kidney disease; CESC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg25405998 chr7:65216604 CCT6P1 0.45 5.35 0.31 1.86e-7 Aortic root size; CESC cis rs9467711 0.606 rs9379899 chr6:26603015 T/A cg12826209 chr6:26865740 GUSBL1 0.66 5.86 0.34 1.4e-8 Autism spectrum disorder or schizophrenia; CESC cis rs72627123 0.867 rs78496651 chr14:74480070 C/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.81 5.36 0.31 1.78e-7 Morning vs. evening chronotype; CESC trans rs4942242 0.663 rs9590779 chr13:44234886 A/G cg19169023 chr15:41853346 TYRO3 0.66 8.48 0.46 1.57e-15 Response to tocilizumab in rheumatoid arthritis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22683624 chr12:133352552 GOLGA3 0.52 6.78 0.38 7.58e-11 Fibrinogen levels; CESC cis rs765787 0.530 rs12323957 chr15:45490773 C/T cg24006582 chr15:45444508 DUOX1 0.57 6.78 0.38 7.92e-11 Uric acid levels; CESC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg07343612 chr16:622815 PIGQ -0.52 -7.52 -0.42 8.53e-13 Height; CESC cis rs8060686 0.641 rs12598274 chr16:68084099 G/A cg26727032 chr16:67993705 SLC12A4 -0.54 -6.16 -0.35 2.65e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs4919087 0.715 rs2484881 chr10:98998266 C/T cg25902810 chr10:99078978 FRAT1 -0.46 -5.2 -0.3 4.03e-7 Monocyte count; CESC cis rs10751667 0.666 rs7394427 chr11:970405 G/A cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.49e-7 Alzheimer's disease (late onset); CESC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs7726839 0.507 rs72703100 chr5:614291 C/T cg16447950 chr5:562315 NA -0.58 -5.93 -0.34 9.42e-9 Obesity-related traits; CESC cis rs11098499 0.955 rs11931312 chr4:120159023 T/C cg24375607 chr4:120327624 NA 0.43 5.21 0.31 3.71e-7 Corneal astigmatism; CESC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg11764359 chr7:65958608 NA -0.74 -10.23 -0.53 6.36e-21 Aortic root size; CESC cis rs1707322 0.717 rs28752166 chr1:46213309 G/A cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs864537 1.000 rs864537 chr1:167411384 A/G cg09179987 chr1:167433047 CD247 0.36 5.43 0.32 1.26e-7 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs921968 0.565 rs586194 chr2:219610433 A/G cg02176678 chr2:219576539 TTLL4 -0.42 -7.44 -0.42 1.43e-12 Mean corpuscular hemoglobin concentration; CESC cis rs11166629 1.000 rs6981735 chr8:135635730 T/C cg27224718 chr8:135614730 ZFAT 0.55 6.8 0.39 6.9e-11 Smoking quantity; CESC cis rs225245 0.782 rs321617 chr17:33915246 A/G cg05299278 chr17:33885742 SLFN14 0.37 5.39 0.31 1.6e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg11644478 chr21:40555479 PSMG1 -0.51 -6.94 -0.39 3.03e-11 Menarche (age at onset); CESC cis rs5769707 0.656 rs135875 chr22:50012419 T/G cg20744362 chr22:50050164 C22orf34 0.35 5.12 0.3 5.92e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg16325326 chr1:53192061 ZYG11B -0.53 -7.96 -0.44 5.13e-14 Monocyte count; CESC cis rs1371867 0.846 rs1660312 chr8:101330634 C/G cg11906718 chr8:101322791 RNF19A 0.53 6.76 0.38 8.54e-11 Atrioventricular conduction; CESC cis rs77216612 0.840 rs11055030 chr12:12878349 G/C cg24098013 chr12:12878779 APOLD1 0.56 6.86 0.39 4.78e-11 Lymphocyte counts; CESC cis rs708547 0.647 rs1403233 chr4:57885053 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.43 5.56 0.32 6.56e-8 Response to bleomycin (chromatid breaks); CESC cis rs4237845 0.788 rs6581157 chr12:58288793 C/T cg00677455 chr12:58241039 CTDSP2 0.63 7.68 0.43 3.1400000000000003e-13 Intelligence (multi-trait analysis); CESC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg14393609 chr7:65229607 NA 0.47 6.21 0.36 2e-9 Calcium levels; CESC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg11764359 chr7:65958608 NA -0.78 -11.22 -0.57 3.73e-24 Aortic root size; CESC cis rs362272 0.545 rs2749782 chr4:3339761 A/G cg14583973 chr4:3374767 RGS12 0.34 5.92 0.34 1.01e-8 Serum sulfate level; CESC trans rs11722228 0.522 rs12503195 chr4:10082772 T/C cg26043149 chr18:55253948 FECH 0.51 6.72 0.38 1.13e-10 Gout;Urate levels;Serum uric acid levels; CESC cis rs854765 0.565 rs4072738 chr17:17884547 A/C cg16928487 chr17:17741425 SREBF1 -0.48 -8.15 -0.45 1.43e-14 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21490161 chr5:180647246 NA 0.48 6.46 0.37 5.01e-10 Fibrinogen levels; CESC cis rs6867032 1.000 rs2129471 chr5:2016236 C/G cg26168224 chr5:2018326 NA 0.96 19.64 0.77 1.3e-53 Gut microbiome composition (winter); CESC cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg11752832 chr7:134001865 SLC35B4 0.54 6.93 0.39 3.22e-11 Mean platelet volume; CESC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11098499 0.865 rs9994730 chr4:120381564 A/C cg24375607 chr4:120327624 NA 0.45 5.51 0.32 8.64e-8 Corneal astigmatism; CESC cis rs7296418 0.663 rs4553407 chr12:123750748 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.12 -0.3 6.01e-7 Platelet count; CESC cis rs12477438 0.520 rs13018891 chr2:99755099 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.46 0.69 7.45e-39 Chronic sinus infection; CESC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.65 -0.38 1.62e-10 Life satisfaction; CESC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg12463550 chr7:65579703 CRCP 0.51 6.36 0.36 8.66e-10 Aortic root size; CESC cis rs4836694 0.574 rs67899211 chr9:132935614 G/A cg13414629 chr9:132935646 FREQ 0.43 5.37 0.31 1.75e-7 Alzheimer's disease (cognitive decline); CESC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg16680214 chr1:154839983 KCNN3 -0.44 -6.79 -0.38 7.4e-11 Prostate cancer; CESC cis rs6430585 0.527 rs2278731 chr2:136396300 T/C cg07169764 chr2:136633963 MCM6 1.03 11.87 0.59 2.4e-26 Corneal structure; CESC cis rs2243480 1.000 rs13235972 chr7:65883605 C/T cg12463550 chr7:65579703 CRCP 0.71 5.49 0.32 9.37e-8 Diabetic kidney disease; CESC trans rs8026198 0.568 rs1678984 chr15:42616332 T/G cg13954090 chr10:73533106 CDH23;C10orf54 -0.69 -6.02 -0.35 5.7e-9 Fibrinogen levels; CESC cis rs1055129 0.681 rs7221792 chr17:73834690 T/G cg02397686 chr17:73851076 WBP2 0.35 5.12 0.3 5.79e-7 White matter hyperintensity burden; CESC cis rs1797081 0.646 rs7090256 chr10:16851949 T/G cg23933602 chr10:16859644 RSU1 0.87 12.75 0.62 2.26e-29 Platelet distribution width; CESC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.51 -0.32 8.3e-8 Aortic root size; CESC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg21784768 chr11:537496 LRRC56 -0.57 -5.38 -0.31 1.65e-7 Body mass index; CESC cis rs4253772 0.550 rs55926596 chr22:46682955 C/T cg00784671 chr22:46762841 CELSR1 -0.61 -5.98 -0.34 7.22e-9 LDL cholesterol;Cholesterol, total; CESC cis rs10911232 0.507 rs10797821 chr1:183012559 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.67 0.64 1.52e-32 Hypertriglyceridemia; CESC cis rs7020830 0.931 rs6476613 chr9:37084340 A/G cg14294708 chr9:37120828 ZCCHC7 1.22 23.54 0.82 6.97e-67 Schizophrenia; CESC trans rs10506458 0.915 rs998505 chr12:63400018 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.34 -18.35 -0.75 4.19e-49 Hemostatic factors and hematological phenotypes; CESC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.22 -0.41 5.5e-12 Total body bone mineral density; CESC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg18404041 chr3:52824283 ITIH1 -0.49 -8.13 -0.45 1.61e-14 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25341937 chr6:17706893 NUP153 -0.46 -6.44 -0.37 5.63e-10 Fibrinogen levels; CESC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg07701084 chr6:150067640 NUP43 0.47 6.73 0.38 1.06e-10 Lung cancer; CESC cis rs1707322 0.752 rs11211147 chr1:46110094 A/G cg03146154 chr1:46216737 IPP 0.82 11.48 0.58 5.01e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2439831 0.850 rs11070408 chr15:44034788 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.97 0.44 4.82e-14 Lung cancer in ever smokers; CESC trans rs17181170 0.574 rs56378315 chr3:87206488 G/C ch.2.199792288R chr2:200084043 NA -0.46 -6.1 -0.35 3.78e-9 Prostate cancer; CESC cis rs748404 0.690 rs2924369 chr15:43777985 G/A cg02155558 chr15:43621948 ADAL;LCMT2 -0.5 -7.74 -0.43 2.06e-13 Lung cancer; CESC cis rs4722166 0.532 rs4719711 chr7:22755688 A/G cg05472934 chr7:22766657 IL6 -0.52 -6.86 -0.39 4.96e-11 Lung cancer; CESC trans rs9870718 0.541 rs35613967 chr3:36245304 T/C cg17530152 chr10:90692333 NA 0.56 6.1 0.35 3.83e-9 Asthma; CESC trans rs6456042 0.893 rs3127440 chr6:166558950 C/T cg01261503 chr17:62493599 POLG2 -0.44 -6.36 -0.36 8.89e-10 Asthma; CESC cis rs2760061 0.819 rs708112 chr1:228192452 G/A cg02753203 chr1:228287806 NA 0.52 7.7 0.43 2.71e-13 Diastolic blood pressure; CESC cis rs7560272 0.538 rs2001436 chr2:73928965 A/T cg20560298 chr2:73613845 ALMS1 0.46 6.35 0.36 9.43e-10 Schizophrenia; CESC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg06456125 chr7:65229604 NA -0.43 -5.44 -0.32 1.21e-7 Cotinine glucuronidation; CESC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg07701084 chr6:150067640 NUP43 0.43 5.71 0.33 3.1e-8 Lung cancer; CESC cis rs17095355 0.901 rs6584964 chr10:111759160 G/C cg00817464 chr10:111662876 XPNPEP1 -0.48 -5.6 -0.33 5.27e-8 Biliary atresia; CESC cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg22467129 chr15:76604101 ETFA -0.38 -5.81 -0.34 1.81e-8 Blood metabolite levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03084103 chr4:38869707 MIR574;FAM114A1 -0.41 -6.02 -0.35 5.79e-9 Gut microbiota (bacterial taxa); CESC cis rs2180341 0.782 rs6912196 chr6:127722732 C/G cg24812749 chr6:127587940 RNF146 0.83 11.9 0.59 1.86e-26 Breast cancer; CESC cis rs9309473 1.000 rs6755241 chr2:73641364 C/T cg20560298 chr2:73613845 ALMS1 -0.53 -7.01 -0.4 2.03e-11 Metabolite levels; CESC cis rs9325144 0.555 rs1813392 chr12:38692203 C/T cg26384229 chr12:38710491 ALG10B -0.58 -8.31 -0.45 5.07e-15 Morning vs. evening chronotype; CESC cis rs3733585 0.624 rs76574510 chr4:9953252 T/A cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7107174 1.000 rs7939352 chr11:78003151 G/A cg27205649 chr11:78285834 NARS2 -0.4 -5.04 -0.3 8.5e-7 Testicular germ cell tumor; CESC cis rs9911578 1.000 rs7215808 chr17:56940742 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.07 0.3 7.54e-7 Intelligence (multi-trait analysis); CESC cis rs116095464 0.558 rs3213838 chr5:223890 G/C cg22496380 chr5:211416 CCDC127 -0.74 -8.72 -0.47 3.15e-16 Breast cancer; CESC cis rs3092073 0.624 rs34293711 chr20:44587186 C/T cg00125455 chr20:44574271 PCIF1 0.35 5.8 0.34 1.84e-8 Intelligence (multi-trait analysis); CESC trans rs17764205 0.777 rs17696630 chr19:3261995 A/G cg03776506 chr16:30581384 ZNF688 0.8 6.45 0.37 5.25e-10 Bipolar disorder and schizophrenia; CESC cis rs6740322 0.748 rs6544634 chr2:43471528 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.77 -8.83 -0.48 1.49e-16 Coronary artery disease; CESC cis rs2228479 0.867 rs34272502 chr16:89949000 G/C cg04013166 chr16:89971882 TCF25 0.77 7.14 0.4 8.86e-12 Skin colour saturation; CESC cis rs9300255 0.782 rs12809602 chr12:123768916 T/G cg19016782 chr12:123741754 C12orf65 0.43 5.31 0.31 2.34e-7 Neutrophil percentage of white cells; CESC cis rs2425143 1.000 rs17093026 chr20:34318911 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.61 -5.37 -0.31 1.77e-7 Blood protein levels; CESC cis rs8031584 1.000 rs35607976 chr15:31277788 T/C cg08109568 chr15:31115862 NA -0.75 -9.43 -0.5 2.12e-18 Huntington's disease progression; CESC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.71 0.38 1.15e-10 Bipolar disorder; CESC cis rs7084402 0.967 rs1582827 chr10:60297102 T/C cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.35e-18 Refractive error; CESC cis rs7772486 0.790 rs6570724 chr6:146151283 T/C cg05347473 chr6:146136440 FBXO30 0.55 7.26 0.41 4.4e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg10691866 chr7:65817282 TPST1 0.31 5.32 0.31 2.25e-7 Aortic root size; CESC cis rs4580814 0.869 rs4535497 chr5:1107428 G/T cg18655438 chr5:1077845 SLC12A7 0.37 5.38 0.31 1.66e-7 Mean corpuscular hemoglobin concentration; CESC cis rs7208859 0.623 rs56325146 chr17:29151024 T/C cg19761014 chr17:28927070 LRRC37B2 0.72 6.08 0.35 4.21e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2228479 0.850 rs17226980 chr16:89825065 G/A cg06558623 chr16:89946397 TCF25 1.17 9.38 0.5 3.19e-18 Skin colour saturation; CESC cis rs7408868 0.764 rs45504393 chr19:15277010 A/G cg14696996 chr19:15285081 NOTCH3 1.11 11.51 0.58 3.92e-25 Pulse pressure; CESC cis rs7044106 0.791 rs10985001 chr9:123484232 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 13.03 0.63 2.43e-30 Hip circumference adjusted for BMI; CESC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.7 10.7 0.55 1.95e-22 Personality dimensions; CESC cis rs4253772 0.575 rs74879643 chr22:46660014 T/C cg18190219 chr22:46762943 CELSR1 -0.56 -5.43 -0.32 1.29e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4423214 1.000 rs12278461 chr11:71182185 C/T cg05163923 chr11:71159392 DHCR7 0.82 10.82 0.55 7.9399999999999994e-23 Vitamin D levels; CESC cis rs10129255 0.500 rs7157975 chr14:107212287 G/A cg07958169 chr14:107095056 NA -0.54 -8.28 -0.45 6.02e-15 Kawasaki disease; CESC cis rs6570726 0.967 rs9497316 chr6:145792387 G/T cg05347473 chr6:146136440 FBXO30 -0.4 -5.48 -0.32 9.96e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg14393609 chr7:65229607 NA 0.52 7.08 0.4 1.3e-11 Aortic root size; CESC cis rs3793683 0.928 rs10781585 chr10:134553369 C/A cg27286337 chr10:134555280 INPP5A -0.92 -15.17 -0.68 7.5e-38 Migraine; CESC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg18099408 chr3:52552593 STAB1 -0.33 -5.45 -0.32 1.17e-7 Bipolar disorder; CESC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg25767906 chr1:53392781 SCP2 -0.45 -5.84 -0.34 1.49e-8 Monocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09429435 chr19:12914994 NA 0.46 6.0 0.35 6.47e-9 Fibrinogen levels; CESC cis rs9916302 0.861 rs3889368 chr17:37683231 C/T cg15445000 chr17:37608096 MED1 0.4 6.56 0.37 2.79e-10 Glomerular filtration rate (creatinine); CESC cis rs2594989 0.943 rs77630528 chr3:11314041 A/G cg00170343 chr3:11313890 ATG7 0.58 5.13 0.3 5.47e-7 Circulating chemerin levels; CESC cis rs6674970 0.541 rs2902811 chr1:151010521 G/C cg03258749 chr1:151040405 MLLT11 -0.41 -5.45 -0.32 1.13e-7 Childhood ear infection; CESC cis rs9815354 0.812 rs73081372 chr3:41917993 C/T cg03022575 chr3:42003672 ULK4 0.66 5.78 0.33 2.09e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg11764359 chr7:65958608 NA -0.72 -9.68 -0.51 3.48e-19 Aortic root size; CESC cis rs2933343 0.700 rs789239 chr3:128633808 T/C cg25356066 chr3:128598488 ACAD9 0.58 7.95 0.44 5.32e-14 IgG glycosylation; CESC cis rs12887734 0.546 rs12886637 chr14:104222892 A/G cg08213375 chr14:104286397 PPP1R13B -0.41 -6.87 -0.39 4.65e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs7077164 1.000 rs1227776 chr10:71580893 G/A cg07630274 chr10:71583235 COL13A1 -0.39 -7.65 -0.43 3.62e-13 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs2274273 0.588 rs9919923 chr14:55813899 A/G cg04306507 chr14:55594613 LGALS3 0.29 5.13 0.3 5.66e-7 Protein biomarker; CESC cis rs2439831 0.850 rs544122 chr15:43775732 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.81 10.65 0.55 2.78e-22 Lung cancer in ever smokers; CESC cis rs2120019 0.608 rs8042558 chr15:75320433 G/T cg17294928 chr15:75287854 SCAMP5 -0.73 -9.09 -0.49 2.31e-17 Blood trace element (Zn levels); CESC cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg19193384 chr17:30244184 NA -0.71 -6.63 -0.38 1.92e-10 Hip circumference adjusted for BMI; CESC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 11.73 0.58 7.11e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9467711 0.659 rs13216828 chr6:26373507 G/A cg14345882 chr6:26364793 BTN3A2 0.61 6.45 0.37 5.32e-10 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07181902 chr2:85829892 TMEM150A 0.71 7.72 0.43 2.35e-13 Gut microbiome composition (summer); CESC cis rs9457247 0.730 rs9459841 chr6:167431949 G/A cg23791538 chr6:167370224 RNASET2 -0.52 -7.15 -0.4 8.6e-12 Crohn's disease; CESC cis rs1018836 1.000 rs1018836 chr8:91570362 A/G cg16814680 chr8:91681699 NA -0.6 -8.39 -0.46 2.97e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs12900413 0.562 rs11631438 chr15:90300620 C/T cg24249390 chr15:90295951 MESP1 -0.41 -5.46 -0.32 1.12e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs909674 0.514 rs7423 chr22:39781429 C/T cg01416388 chr22:39784598 NA -0.49 -6.5 -0.37 3.93e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs2279817 0.818 rs34421778 chr1:17984859 C/G cg21791023 chr1:18019539 ARHGEF10L -0.66 -7.97 -0.44 4.73e-14 Neuroticism; CESC cis rs9611565 0.729 rs202654 chr22:41841034 G/A cg03806693 chr22:41940476 POLR3H 0.77 9.9 0.52 7.28e-20 Vitiligo; CESC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg18305652 chr10:134549665 INPP5A 0.45 6.26 0.36 1.53e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6674176 0.597 rs9326136 chr1:44390392 A/G cg23954153 chr1:44402353 ARTN 0.36 5.83 0.34 1.63e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6912958 0.712 rs7755167 chr6:88338752 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.72 -0.38 1.09e-10 Monocyte percentage of white cells; CESC cis rs8002861 0.905 rs12873099 chr13:44396247 G/A cg19180546 chr13:44453867 C13orf31;CCDC122 -0.45 -5.58 -0.32 6.02e-8 Leprosy; CESC cis rs6088580 0.634 rs6088478 chr20:32971719 T/C cg24642439 chr20:33292090 TP53INP2 -0.52 -6.9 -0.39 3.82e-11 Glomerular filtration rate (creatinine); CESC cis rs6120849 0.901 rs6060278 chr20:33753262 T/C cg24642439 chr20:33292090 TP53INP2 0.58 6.31 0.36 1.18e-9 Protein C levels; CESC cis rs793571 0.544 rs12912699 chr15:58917021 T/C cg05156742 chr15:59063176 FAM63B 0.79 11.47 0.58 5.31e-25 Schizophrenia; CESC cis rs7224314 1.000 rs62084077 chr17:65386837 G/A cg01507342 chr17:65387096 PITPNC1 -0.47 -5.72 -0.33 2.83e-8 Diisocyanate-induced asthma; CESC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.93e-7 Lung cancer; CESC cis rs7714584 0.793 rs2161363 chr5:150182079 G/C cg22134413 chr5:150180641 NA 0.62 5.79 0.34 1.96e-8 Crohn's disease; CESC cis rs1707322 0.928 rs61785614 chr1:46446047 A/G cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6811802 1 rs6811802 chr4:78932838 G/C cg07207937 chr4:78783799 MRPL1 -0.83 -8.89 -0.48 9.66e-17 Left ventricular obstructive tract defect (inherited effect); CESC cis rs6736093 0.966 rs34705448 chr2:112730089 C/T cg12686935 chr2:112915763 FBLN7 -0.44 -5.72 -0.33 2.86e-8 Coronary artery disease; CESC trans rs748404 0.631 rs6493084 chr15:43647627 A/G cg24053811 chr14:70265306 SLC10A1 0.43 6.06 0.35 4.72e-9 Lung cancer; CESC trans rs2391518 0.639 rs2969003 chr4:130781879 A/T cg04981619 chr2:43328122 NA 0.38 6.0 0.35 6.59e-9 Body mass index; CESC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg16325326 chr1:53192061 ZYG11B 0.94 16.56 0.71 9.15e-43 Monocyte count; CESC cis rs4423214 0.840 rs1790343 chr11:71177207 T/C cg05163923 chr11:71159392 DHCR7 -0.65 -7.55 -0.42 6.91e-13 Vitamin D levels; CESC cis rs6963495 1.000 rs6963495 chr7:105166853 T/C cg13798780 chr7:105162888 PUS7 0.73 6.59 0.38 2.34e-10 Bipolar disorder (body mass index interaction); CESC cis rs12142240 0.698 rs17357676 chr1:46812444 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.29 0.36 1.33e-9 Menopause (age at onset); CESC cis rs1178968 1.000 rs6460041 chr7:72757671 A/G cg25889504 chr7:72793014 NA 0.48 5.08 0.3 7.22e-7 Triglyceride levels; CESC cis rs660498 0.507 rs11015783 chr10:27729745 A/G cg25705717 chr10:27608719 NA 0.49 5.84 0.34 1.49e-8 Asthma (childhood onset); CESC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg18876405 chr7:65276391 NA -0.66 -9.1 -0.49 2.16e-17 Aortic root size; CESC cis rs9790314 1.000 rs9846756 chr3:160983809 A/C cg04691961 chr3:161091175 C3orf57 -0.41 -5.22 -0.31 3.56e-7 Morning vs. evening chronotype; CESC cis rs4253772 0.591 rs113101219 chr22:46659186 C/A cg24881330 chr22:46731750 TRMU 0.8 6.6 0.38 2.24e-10 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04672650 chr10:96943563 NA 0.53 6.4 0.37 7.13e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs13148324 chr4:98833616 G/A cg05340658 chr4:99064831 C4orf37 0.72 10.37 0.54 2.25e-21 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg08736216 chr1:53307985 ZYG11A 0.39 6.68 0.38 1.42e-10 Monocyte count; CESC cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg02551604 chr5:131831745 NA -0.37 -5.27 -0.31 2.81e-7 Asthma (sex interaction); CESC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg11890956 chr21:40555474 PSMG1 -0.67 -9.25 -0.49 7.56e-18 Menarche (age at onset); CESC cis rs7845219 0.544 rs7015841 chr8:95920193 A/C cg09323728 chr8:95962352 TP53INP1 -0.34 -6.59 -0.38 2.41e-10 Type 2 diabetes; CESC cis rs1642645 0.757 rs6600394 chr1:42472453 T/C cg16685388 chr1:42384056 HIVEP3 0.37 5.6 0.33 5.26e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs3105593 1.000 rs3131589 chr15:50841053 G/C cg08437265 chr15:50716283 USP8 0.43 5.53 0.32 7.62e-8 QT interval; CESC cis rs2795502 1.000 rs2744090 chr10:43339614 G/C cg20628663 chr10:43360327 NA -0.63 -7.47 -0.42 1.16e-12 Blood protein levels; CESC cis rs10129255 0.957 rs6576228 chr14:107186640 A/G cg07958169 chr14:107095056 NA -0.42 -5.88 -0.34 1.26e-8 Kawasaki disease; CESC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg03188948 chr7:1209495 NA 0.72 6.91 0.39 3.61e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25586305 chr2:234281690 DGKD 0.45 6.01 0.35 6.09e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs524281 0.861 rs7942894 chr11:65976525 T/C cg14036092 chr11:66035641 RAB1B -0.5 -5.38 -0.31 1.64e-7 Electroencephalogram traits; CESC cis rs6866344 0.697 rs11748495 chr5:178130000 A/G cg03877680 chr5:178157825 ZNF354A -0.75 -8.59 -0.47 7.68e-16 Neutrophil percentage of white cells; CESC cis rs4654899 0.865 rs7541923 chr1:21403582 G/C cg05370193 chr1:21551575 ECE1 0.43 6.61 0.38 2.05e-10 Superior frontal gyrus grey matter volume; CESC cis rs5758659 0.714 rs133376 chr22:42466905 C/T cg19513890 chr22:42538836 CYP2D7P1 -0.38 -5.62 -0.33 4.73e-8 Cognitive function; CESC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg22143856 chr6:28129313 ZNF389 0.41 5.22 0.31 3.64e-7 Parkinson's disease; CESC cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18900838 chr17:28804337 GOSR1 -0.63 -7.39 -0.41 1.92e-12 Gut microbiome composition (summer); CESC cis rs9303401 0.573 rs35104446 chr17:57180234 A/C cg12560992 chr17:57184187 TRIM37 0.51 5.28 0.31 2.68e-7 Cognitive test performance; CESC cis rs9457247 0.663 rs12526548 chr6:167431147 C/T cg07741184 chr6:167504864 NA 0.34 6.12 0.35 3.27e-9 Crohn's disease; CESC cis rs11122272 0.701 rs971533 chr1:231522097 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg03709012 chr19:19516395 GATAD2A 1.01 16.05 0.7 5.61e-41 Tonsillectomy; CESC cis rs8062405 1.000 rs62037369 chr16:28883841 C/T cg08761264 chr16:28874980 SH2B1 -0.45 -5.49 -0.32 9.61e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs67311347 1.000 rs66841330 chr3:40531123 G/A cg09455208 chr3:40491958 NA 0.46 7.34 0.41 2.69e-12 Renal cell carcinoma; CESC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg13777783 chr17:79615861 NA -0.34 -5.75 -0.33 2.49e-8 Eye color traits; CESC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg09365446 chr1:150670422 GOLPH3L 0.39 5.35 0.31 1.92e-7 Tonsillectomy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09068198 chr2:65357064 RAB1A 0.48 6.19 0.36 2.25e-9 Gut microbiota (bacterial taxa); CESC cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg20503657 chr10:835505 NA 1.09 10.01 0.52 3.32e-20 Eosinophil percentage of granulocytes; CESC cis rs1670533 0.818 rs643484 chr4:1085826 A/G cg27284194 chr4:1044797 NA 0.48 6.17 0.35 2.6e-9 Recombination rate (females); CESC cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.86 8.98 0.48 5.03e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs56104184 0.775 rs56317021 chr19:49395960 C/T cg21252483 chr19:49399788 TULP2 -0.53 -5.72 -0.33 2.94e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs8072100 0.817 rs9892497 chr17:45545919 G/A cg25173405 chr17:45401733 C17orf57 -0.47 -6.16 -0.35 2.68e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg17724175 chr1:150552817 MCL1 0.33 5.18 0.3 4.49e-7 Melanoma; CESC cis rs7914558 0.966 rs10786725 chr10:104682357 T/C cg04362960 chr10:104952993 NT5C2 0.43 5.54 0.32 7.17e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg10691866 chr7:65817282 TPST1 -0.33 -5.42 -0.32 1.34e-7 Aortic root size; CESC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg18404041 chr3:52824283 ITIH1 -0.42 -7.13 -0.4 9.59e-12 Bipolar disorder; CESC cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs62103177 0.810 rs62103195 chr18:77629693 T/C cg12964065 chr18:77638022 KCNG2 0.59 5.51 0.32 8.57e-8 Opioid sensitivity; CESC cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg22903471 chr2:27725779 GCKR -0.56 -7.62 -0.42 4.62e-13 Total body bone mineral density; CESC cis rs3091242 0.933 rs35403885 chr1:25784551 G/A cg12412775 chr1:25698385 RHCE 0.28 5.12 0.3 5.94e-7 Erythrocyte sedimentation rate; CESC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg11861562 chr11:117069780 TAGLN -0.31 -5.38 -0.31 1.64e-7 Blood protein levels; CESC cis rs6598955 0.543 rs3795689 chr1:26560366 C/G cg04990556 chr1:26633338 UBXN11 0.84 9.59 0.51 6.82e-19 Obesity-related traits; CESC cis rs10097731 1.000 rs10097731 chr8:82027672 G/T cg25230327 chr8:82042993 NA -0.61 -6.99 -0.39 2.27e-11 Serum total protein level; CESC cis rs12410462 0.681 rs4614224 chr1:227574966 C/T cg04117972 chr1:227635322 NA 0.75 6.22 0.36 1.93e-9 Major depressive disorder; CESC cis rs28498503 0.867 rs28536126 chr18:76649586 G/A cg00806245 chr18:76673096 NA -0.52 -5.31 -0.31 2.29e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs1891275 0.513 rs1539041 chr10:93577141 T/G cg12805727 chr10:93557676 TNKS2 0.49 5.68 0.33 3.58e-8 Intelligence (multi-trait analysis); CESC cis rs7671266 0.668 rs6834055 chr4:10158511 A/T cg00071950 chr4:10020882 SLC2A9 -0.55 -5.97 -0.34 7.54e-9 Cardiovascular disease risk factors; CESC trans rs11098499 0.629 rs28369518 chr4:120271630 T/C cg25214090 chr10:38739885 LOC399744 0.6 8.3 0.45 5.33e-15 Corneal astigmatism; CESC cis rs6840258 1.000 rs56390363 chr4:87943087 G/A cg08197287 chr4:87952173 AFF1 -0.41 -5.47 -0.32 1.02e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs7107174 1.000 rs2510040 chr11:77944548 T/A cg02023728 chr11:77925099 USP35 0.53 7.08 0.4 1.26e-11 Testicular germ cell tumor; CESC cis rs116095464 0.558 rs56081398 chr5:247318 C/T cg22857025 chr5:266934 NA -1.29 -14.08 -0.65 5.3e-34 Breast cancer; CESC cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg03146154 chr1:46216737 IPP 0.48 6.32 0.36 1.12e-9 Red blood cell count;Reticulocyte count; CESC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg11764359 chr7:65958608 NA 0.81 11.89 0.59 2.11e-26 Aortic root size; CESC cis rs7647973 1.000 rs2312462 chr3:49601255 A/G cg07636037 chr3:49044803 WDR6 0.61 8.73 0.47 2.98e-16 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21528136 chr17:73901016 MRPL38 0.56 6.43 0.37 5.93e-10 Gut microbiome composition (summer); CESC cis rs7089973 0.604 rs2420069 chr10:116605103 A/G cg03647239 chr10:116582469 FAM160B1 0.43 5.35 0.31 1.94e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs963731 0.579 rs1454226 chr2:39246862 A/G cg04010122 chr2:39346883 SOS1 -0.72 -5.37 -0.31 1.7e-7 Corticobasal degeneration; CESC trans rs3780486 0.522 rs10217770 chr9:33146393 C/A cg20290983 chr6:43655470 MRPS18A 0.73 11.18 0.57 4.97e-24 IgG glycosylation; CESC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg03709012 chr19:19516395 GATAD2A -0.98 -14.29 -0.66 1.02e-34 Tonsillectomy; CESC cis rs6963495 0.818 rs818619 chr7:105172505 A/T cg19920283 chr7:105172520 RINT1 0.72 8.05 0.44 2.75e-14 Bipolar disorder (body mass index interaction); CESC cis rs896854 0.738 rs481887 chr8:95967838 A/G cg13393036 chr8:95962371 TP53INP1 0.47 9.03 0.49 3.59e-17 Type 2 diabetes; CESC cis rs826838 1.000 rs6582619 chr12:38729904 A/G cg13010199 chr12:38710504 ALG10B 0.62 8.73 0.47 2.87e-16 Heart rate; CESC cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg00701064 chr4:6280414 WFS1 0.69 11.74 0.58 6.7e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00139389 chr7:150741207 ABCB8 -0.58 -6.1 -0.35 3.64e-9 Gut microbiome composition (summer); CESC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg19046167 chr17:80928561 B3GNTL1 0.41 5.48 0.32 9.72e-8 Breast cancer; CESC cis rs561341 1.000 rs15654 chr17:30326360 A/C cg23018236 chr17:30244563 NA -0.52 -5.11 -0.3 6.12e-7 Hip circumference adjusted for BMI; CESC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg13770153 chr20:60521292 NA -0.5 -6.17 -0.35 2.54e-9 Body mass index; CESC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg10691866 chr7:65817282 TPST1 -0.35 -5.95 -0.34 8.45e-9 Aortic root size; CESC cis rs992157 0.717 rs3817266 chr2:219142594 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.67 -8.69 -0.47 3.72e-16 Colorectal cancer; CESC cis rs7666738 0.830 rs17027102 chr4:98919221 A/G cg03467027 chr4:99064603 C4orf37 -0.41 -5.13 -0.3 5.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs919433 0.889 rs12693816 chr2:198208420 T/A cg20885578 chr2:198174922 NA -0.38 -5.06 -0.3 7.87e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9486719 0.656 rs4839826 chr6:96853616 A/G cg18709589 chr6:96969512 KIAA0776 -0.44 -5.25 -0.31 3.09e-7 Migraine;Coronary artery disease; CESC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.14 -0.4 8.75e-12 Personality dimensions; CESC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg09658497 chr7:2847517 GNA12 -0.42 -5.85 -0.34 1.44e-8 Height; CESC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg06873352 chr17:61820015 STRADA 0.72 12.93 0.62 5.79e-30 Prudent dietary pattern; CESC cis rs66569888 0.754 rs6719028 chr2:106895212 T/C cg15412446 chr2:106886593 NA 0.68 8.02 0.44 3.34e-14 Facial morphology (factor 23); CESC cis rs75887402 1.000 rs10519724 chr5:122712563 G/A cg27033705 chr5:122759302 CEP120 0.93 6.19 0.36 2.28e-9 Breast cancer; CESC cis rs7246657 0.943 rs7408563 chr19:37808585 G/C cg23950597 chr19:37808831 NA -0.6 -6.4 -0.37 6.98e-10 Coronary artery calcification; CESC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 10.91 0.56 3.82e-23 Platelet count; CESC cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg03213289 chr20:61660250 NA 0.39 6.16 0.35 2.7e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs11098499 0.863 rs10009626 chr4:120470005 T/C cg24375607 chr4:120327624 NA 0.44 5.36 0.31 1.84e-7 Corneal astigmatism; CESC cis rs11893307 0.507 rs1465304 chr2:191585398 A/G cg10560079 chr2:191398806 TMEM194B -0.45 -5.59 -0.32 5.55e-8 Mean platelet volume; CESC cis rs11122272 0.735 rs11122279 chr1:231519804 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.11 0.35 3.47e-9 Hemoglobin concentration; CESC cis rs9611565 0.722 rs202635 chr22:41809637 C/T cg06481639 chr22:41940642 POLR3H 0.62 6.52 0.37 3.49e-10 Vitiligo; CESC cis rs10737909 1.000 rs10803369 chr1:15550525 G/T cg21012057 chr1:15538911 TMEM51 -0.43 -6.09 -0.35 3.98e-9 Migraine; CESC cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2204008 0.627 rs11176531 chr12:38152166 T/G cg26384229 chr12:38710491 ALG10B 0.73 10.02 0.52 3.02e-20 Bladder cancer; CESC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg11764359 chr7:65958608 NA 0.97 15.58 0.69 2.77e-39 Aortic root size; CESC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg24562669 chr7:97807699 LMTK2 0.48 6.8 0.39 6.74e-11 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11913218 chr1:10754156 CASZ1 0.52 6.0 0.35 6.52e-9 Gut microbiome composition (summer); CESC cis rs6496667 0.533 rs7172909 chr15:90991416 C/T cg10434728 chr15:90938212 IQGAP1 0.31 5.45 0.32 1.13e-7 Rheumatoid arthritis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10824722 chr1:206506826 NA -0.47 -6.95 -0.39 2.87e-11 Gut microbiota (bacterial taxa); CESC cis rs9911578 0.967 rs4598970 chr17:57076893 T/A cg12560992 chr17:57184187 TRIM37 -0.99 -16.91 -0.72 5.06e-44 Intelligence (multi-trait analysis); CESC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg22143856 chr6:28129313 ZNF389 0.49 6.18 0.35 2.47e-9 Depression; CESC cis rs8013055 0.898 rs8014913 chr14:105977313 T/C cg23356831 chr14:105996513 TMEM121 0.37 5.13 0.3 5.53e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC cis rs11969893 0.850 rs9498414 chr6:101322976 C/T cg12253828 chr6:101329408 ASCC3 0.92 7.84 0.43 1.12e-13 Economic and political preferences (immigration/crime); CESC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg02951883 chr7:2050386 MAD1L1 -0.44 -5.62 -0.33 4.93e-8 Bipolar disorder and schizophrenia; CESC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg05368731 chr17:41323189 NBR1 0.6 8.37 0.46 3.43e-15 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24601517 chr6:5004202 RPP40 0.56 6.32 0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg18230493 chr5:56204884 C5orf35 0.61 7.98 0.44 4.33e-14 Initial pursuit acceleration; CESC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg08704611 chr17:80376099 HEXDC;C17orf101 -0.45 -5.16 -0.3 4.79e-7 Breast cancer; CESC cis rs796364 0.950 rs188146 chr2:200750444 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.87 8.64 0.47 5.23e-16 Schizophrenia; CESC cis rs9291683 0.618 rs13137343 chr4:10043028 C/A cg00071950 chr4:10020882 SLC2A9 0.83 14.41 0.66 3.63e-35 Bone mineral density; CESC cis rs42648 0.870 rs7783199 chr7:89999305 G/A cg23697855 chr7:89950296 NA -0.27 -5.12 -0.3 5.74e-7 Homocysteine levels; CESC cis rs748404 0.560 rs2255663 chr15:43829008 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.48 -7.34 -0.41 2.67e-12 Lung cancer; CESC cis rs17666538 0.710 rs11987001 chr8:630755 T/C cg07234876 chr8:600039 NA 0.78 5.48 0.32 1.01e-7 IgG glycosylation; CESC cis rs7524258 0.835 rs2412150 chr1:7303343 A/C cg07173049 chr1:7289937 CAMTA1 0.42 6.24 0.36 1.74e-9 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs6088580 0.634 rs4911423 chr20:32999386 T/A cg06115741 chr20:33292138 TP53INP2 -0.47 -6.03 -0.35 5.36e-9 Glomerular filtration rate (creatinine); CESC cis rs7255436 0.965 rs11666003 chr19:8452102 G/A cg16745616 chr19:8428856 ANGPTL4 -0.36 -5.49 -0.32 9.22e-8 HDL cholesterol; CESC cis rs9399137 0.507 rs56164974 chr6:135288716 C/T cg24558204 chr6:135376177 HBS1L 0.7 9.61 0.51 5.91e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs17362650 0.653 rs12474647 chr2:9554280 A/T cg12832956 chr2:9616023 IAH1 -0.57 -6.63 -0.38 1.89e-10 Alcohol dependence (age at onset); CESC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg24101359 chr6:42928495 GNMT 0.62 9.51 0.5 1.22e-18 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7107174 1.000 rs2510047 chr11:77988668 C/T cg02023728 chr11:77925099 USP35 -0.35 -5.18 -0.3 4.45e-7 Testicular germ cell tumor; CESC cis rs6032067 0.598 rs2741500 chr20:43944958 G/T cg10761708 chr20:43804764 PI3 0.44 5.32 0.31 2.17e-7 Blood protein levels; CESC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg00745463 chr17:30367425 LRRC37B -0.6 -5.81 -0.34 1.8e-8 Hip circumference adjusted for BMI; CESC cis rs7264396 0.635 rs6121073 chr20:34457513 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.4 0.41 1.75e-12 Total cholesterol levels; CESC cis rs597583 0.664 rs4938395 chr11:117384673 C/T cg27161313 chr11:117392002 DSCAML1 0.5 6.22 0.36 1.93e-9 Putamen volume; CESC cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg27478167 chr7:817139 HEATR2 -0.49 -5.35 -0.31 1.87e-7 Cerebrospinal P-tau181p levels; CESC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg23131131 chr22:24373011 LOC391322 -0.65 -8.86 -0.48 1.15e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs11785400 1.000 rs11780221 chr8:143748215 T/A cg10596483 chr8:143751796 JRK 0.44 5.72 0.33 2.8e-8 Schizophrenia; CESC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg05863683 chr7:1912471 MAD1L1 0.5 7.75 0.43 2.02e-13 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07491375 chr4:71705274 GRSF1 0.56 7.11 0.4 1.06e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17099683 chr14:96969243 PAPOLA -0.58 -6.42 -0.37 6.18e-10 Gut microbiome composition (summer); CESC cis rs926938 0.584 rs1299780 chr1:115366014 G/A cg12756093 chr1:115239321 AMPD1 0.45 6.04 0.35 5.1e-9 Autism; CESC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg18225595 chr11:63971243 STIP1 0.53 5.57 0.32 6.17e-8 Mean platelet volume; CESC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs35740288 0.539 rs34362339 chr15:86337628 C/T cg20737812 chr15:86336631 KLHL25 -0.42 -5.28 -0.31 2.71e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs9811920 0.609 rs793460 chr3:99615733 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs7660520 0.557 rs76004373 chr4:183731011 C/G cg04526738 chr4:183727387 NA 0.7 6.58 0.37 2.5e-10 Pediatric autoimmune diseases; CESC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg12963246 chr6:28129442 ZNF389 0.49 6.35 0.36 9.29e-10 Parkinson's disease; CESC cis rs67311347 0.911 rs6775936 chr3:40377399 T/G cg24209194 chr3:40518798 ZNF619 0.42 5.36 0.31 1.83e-7 Renal cell carcinoma; CESC trans rs875971 1.000 rs11971949 chr7:65626014 A/G cg26939375 chr7:64535504 NA -0.47 -6.16 -0.35 2.69e-9 Aortic root size; CESC cis rs3820928 0.874 rs10207404 chr2:227794420 T/C cg05526886 chr2:227700861 RHBDD1 -0.4 -5.12 -0.3 5.87e-7 Pulmonary function; CESC cis rs5758659 0.652 rs4822084 chr22:42435868 A/G cg04733989 chr22:42467013 NAGA -0.44 -5.92 -0.34 9.79e-9 Cognitive function; CESC cis rs113835537 0.877 rs3867132 chr11:66309269 C/T cg24851651 chr11:66362959 CCS 0.61 5.52 0.32 8.26e-8 Airway imaging phenotypes; CESC cis rs2425143 0.908 rs75331436 chr20:34391052 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.93 0.34 9.19e-9 Blood protein levels; CESC cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg25019033 chr10:957182 NA -0.59 -6.32 -0.36 1.08e-9 Eosinophil percentage of granulocytes; CESC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs11514810 1.000 rs9648620 chr7:1427980 T/C cg24899294 chr7:1481343 MICALL2 -0.62 -5.37 -0.31 1.74e-7 Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder; CESC cis rs6496667 1.000 rs7182544 chr15:90897480 G/C cg22089800 chr15:90895588 ZNF774 0.57 5.76 0.33 2.27e-8 Rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18228282 chr17:46703908 HOXB9 0.52 6.27 0.36 1.47e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16352085 chr1:859719 SAMD11 0.61 6.41 0.37 6.72e-10 Gut microbiome composition (summer); CESC cis rs7116495 0.737 rs7126838 chr11:71826237 A/G cg10381502 chr11:71823885 C11orf51 0.65 5.45 0.32 1.15e-7 Severe influenza A (H1N1) infection; CESC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -5.42 -0.32 1.35e-7 Developmental language disorder (linguistic errors); CESC cis rs79057730 0.599 rs112891948 chr7:816059 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.91 7.83 0.43 1.15e-13 Initial pursuit acceleration; CESC cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg22834771 chr12:69754056 YEATS4 -0.48 -6.46 -0.37 4.87e-10 Blood protein levels; CESC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg12463550 chr7:65579703 CRCP 0.57 7.15 0.4 8.68e-12 Aortic root size; CESC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg25985355 chr7:65971099 NA -0.31 -5.04 -0.3 8.47e-7 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04260516 chr14:24630327 IRF9 0.51 6.57 0.37 2.66e-10 Gut microbiota (bacterial taxa); CESC cis rs708547 0.915 rs28605409 chr4:57766261 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.67 7.33 0.41 2.78e-12 Response to bleomycin (chromatid breaks); CESC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg19678392 chr7:94953810 PON1 -0.48 -7.73 -0.43 2.31e-13 Paraoxonase activity; CESC cis rs2228479 0.867 rs62056110 chr16:89946388 A/C cg14709524 chr16:89940631 TCF25 0.74 5.75 0.33 2.43e-8 Skin colour saturation; CESC cis rs7216064 0.953 rs1966410 chr17:65837215 T/C cg12091567 chr17:66097778 LOC651250 -0.8 -9.08 -0.49 2.62e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs72781680 1.000 rs72796339 chr2:24143063 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg00166722 chr3:10149974 C3orf24 0.49 6.28 0.36 1.35e-9 Alzheimer's disease; CESC cis rs6815814 0.950 rs55903115 chr4:38786474 C/A cg02016764 chr4:38805732 TLR1 -0.64 -7.93 -0.44 6.35e-14 Breast cancer; CESC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.79 0.39 7.14e-11 Bipolar disorder; CESC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg11644478 chr21:40555479 PSMG1 1.05 16.84 0.72 9.02e-44 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02469457 chr2:242254758 SEPT2;HDLBP 0.59 6.38 0.36 7.83e-10 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg08888203 chr3:10149979 C3orf24 0.47 6.03 0.35 5.4e-9 Alzheimer's disease; CESC cis rs36051895 0.695 rs60221565 chr9:5029077 T/G cg02405213 chr9:5042618 JAK2 -0.49 -5.78 -0.33 2.05e-8 Pediatric autoimmune diseases; CESC cis rs7084402 0.967 rs1649030 chr10:60279830 G/A cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.83e-18 Refractive error; CESC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg07701084 chr6:150067640 NUP43 0.46 6.3 0.36 1.24e-9 Lung cancer; CESC cis rs6500395 1.000 rs1558817 chr16:48730722 G/A cg04672837 chr16:48644449 N4BP1 0.47 5.58 0.32 6.02e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7264396 0.563 rs2425116 chr20:34323553 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.86 0.39 4.77e-11 Total cholesterol levels; CESC cis rs208520 0.739 rs1935894 chr6:66891434 A/G cg07460842 chr6:66804631 NA -0.93 -11.85 -0.59 2.81e-26 Exhaled nitric oxide output; CESC cis rs754466 0.580 rs10824576 chr10:79566040 G/C cg17075019 chr10:79541650 NA -0.82 -13.42 -0.64 1.14e-31 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7412746 0.658 rs10888397 chr1:150886752 A/G cg18016565 chr1:150552671 MCL1 -0.33 -5.07 -0.3 7.34e-7 Melanoma; CESC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg02807482 chr3:125708958 NA -0.39 -5.08 -0.3 7.17e-7 Blood pressure (smoking interaction); CESC cis rs8049040 0.609 rs7188858 chr16:71468895 T/C cg08717414 chr16:71523259 ZNF19 -0.56 -6.39 -0.37 7.37e-10 Blood protein levels; CESC cis rs72781680 1.000 rs7355559 chr2:24256946 G/T cg20701182 chr2:24300061 SF3B14 -0.74 -7.36 -0.41 2.37e-12 Lymphocyte counts; CESC cis rs7949030 0.626 rs61296092 chr11:62320838 T/C cg11742103 chr11:62369870 EML3;MTA2 0.65 9.81 0.52 1.35e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg06481639 chr22:41940642 POLR3H 0.62 6.06 0.35 4.65e-9 Vitiligo; CESC cis rs6831352 0.703 rs3133152 chr4:100031721 C/G cg13256891 chr4:100009986 ADH5 0.69 8.13 0.45 1.61e-14 Alcohol dependence; CESC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg03806693 chr22:41940476 POLR3H -1.21 -15.69 -0.69 1.07e-39 Vitiligo; CESC cis rs7617773 0.780 rs13085251 chr3:48340045 C/T cg11946769 chr3:48343235 NME6 0.89 12.11 0.6 3.63e-27 Coronary artery disease; CESC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg02187348 chr16:89574699 SPG7 -0.64 -9.02 -0.48 3.94e-17 Multiple myeloma (IgH translocation); CESC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg03517284 chr6:25882590 NA -0.42 -5.81 -0.34 1.8e-8 Intelligence (multi-trait analysis); CESC cis rs9911578 0.967 rs57869245 chr17:57106630 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -5.25 -0.31 3.12e-7 Intelligence (multi-trait analysis); CESC cis rs12220238 1.000 rs10824075 chr10:75880254 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.65 6.42 0.37 6.1e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs12369635 1.000 rs12372807 chr12:129561332 C/T cg01909103 chr12:129572610 TMEM132D -0.65 -5.95 -0.34 8.64e-9 Schizophrenia (inflammation and infection response interaction); CESC cis rs1801251 1.000 rs7578299 chr2:233573469 G/T cg25237894 chr2:233734115 C2orf82 0.5 8.49 0.46 1.45e-15 Coronary artery disease; CESC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs9937943 0.721 rs8059315 chr16:74506447 C/G cg01733217 chr16:74700730 RFWD3 0.62 5.69 0.33 3.37e-8 Neutrophil percentage of white cells; CESC trans rs3741489 1.000 rs2062162 chr12:133432744 C/T cg24132527 chr5:140019269 TMCO6 1.19 8.86 0.48 1.16e-16 Cognitive function; CESC cis rs2228479 0.867 rs57940434 chr16:89975496 G/A cg04013166 chr16:89971882 TCF25 0.7 6.91 0.39 3.7e-11 Skin colour saturation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22792938 chr2:228337242 AGFG1 -0.41 -6.64 -0.38 1.81e-10 Gambling; CESC cis rs10905065 0.827 rs10752111 chr10:5837286 T/C cg11519256 chr10:5708881 ASB13 0.44 6.12 0.35 3.39e-9 Menopause (age at onset); CESC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.09 10.29 0.53 4.06e-21 Platelet count; CESC cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg24562669 chr7:97807699 LMTK2 -0.6 -8.38 -0.46 3.18e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs9911578 1.000 rs304299 chr17:56838472 C/G cg12560992 chr17:57184187 TRIM37 0.92 15.29 0.68 2.77e-38 Intelligence (multi-trait analysis); CESC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg04414720 chr1:150670196 GOLPH3L -0.37 -5.2 -0.3 4.06e-7 Tonsillectomy; CESC cis rs258892 0.895 rs16901131 chr5:72054836 C/T cg21869765 chr5:72125136 TNPO1 -0.42 -5.32 -0.31 2.2e-7 Small cell lung carcinoma; CESC cis rs67478160 0.572 rs8016014 chr14:104293798 G/C cg08213375 chr14:104286397 PPP1R13B 0.52 10.42 0.54 1.54e-21 Schizophrenia; CESC cis rs3092073 0.624 rs3848719 chr20:44596545 G/A cg00981651 chr20:44574847 PCIF1 0.38 5.59 0.33 5.51e-8 Intelligence (multi-trait analysis); CESC cis rs7267979 0.966 rs2151144 chr20:25414924 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.22 -0.71 1.47e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs3820068 0.581 rs16851851 chr1:15929628 C/G cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC trans rs7307889 0.793 rs10161529 chr12:6013122 G/A cg18407955 chr7:158110685 PTPRN2 -0.72 -6.67 -0.38 1.45e-10 Obesity-related traits; CESC cis rs2797160 0.967 rs2747715 chr6:126007719 A/T cg05901451 chr6:126070800 HEY2 0.45 6.53 0.37 3.4e-10 Endometrial cancer; CESC cis rs950776 0.518 rs11630349 chr15:78824608 C/T cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg22823121 chr1:150693482 HORMAD1 0.44 6.15 0.35 2.85e-9 Melanoma; CESC cis rs2276314 0.857 rs59649576 chr18:33616075 G/T cg19628046 chr18:33552617 C18orf21 0.53 5.97 0.34 7.5e-9 Endometriosis;Drug-induced torsades de pointes; CESC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg14703610 chr5:56206110 C5orf35 0.42 5.22 0.31 3.54e-7 Coronary artery disease; CESC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 9.59 0.51 6.76e-19 Platelet count; CESC cis rs9837602 0.810 rs9854260 chr3:99850212 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 5.04 0.3 8.6e-7 Breast cancer; CESC cis rs2797160 0.967 rs1739355 chr6:126018114 A/G cg05901451 chr6:126070800 HEY2 0.45 6.38 0.36 7.82e-10 Endometrial cancer; CESC cis rs1178968 0.901 rs7783232 chr7:72765171 C/G cg25889504 chr7:72793014 NA 0.48 5.11 0.3 6.25e-7 Triglyceride levels; CESC cis rs10411936 0.626 rs8113060 chr19:16596795 G/C cg10248733 chr19:16607483 C19orf44;CALR3 0.58 6.9 0.39 3.75e-11 White blood cell count;Multiple sclerosis; CESC cis rs25645 0.760 rs11870683 chr17:38129841 T/A cg17467752 chr17:38218738 THRA -0.42 -5.47 -0.32 1.06e-7 Myeloid white cell count; CESC cis rs7039377 0.513 rs7854134 chr9:38672523 C/T cg14625731 chr9:38672608 NA -0.42 -5.53 -0.32 7.62e-8 Obesity-related traits; CESC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.88 0.34 1.23e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs45535039 1.000 rs10892342 chr11:119135814 T/C cg16724696 chr11:118992527 HINFP 0.4 5.11 0.3 6.21e-7 Plateletcrit; CESC cis rs763121 0.853 rs2281021 chr22:39064667 T/C cg06022373 chr22:39101656 GTPBP1 0.88 13.95 0.65 1.51e-33 Menopause (age at onset); CESC cis rs9837602 1.000 rs17379739 chr3:99724792 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.48 7.04 0.4 1.66e-11 Breast cancer; CESC cis rs12477438 0.520 rs13012481 chr2:99754290 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.92 0.7 1.72e-40 Chronic sinus infection; CESC trans rs3741578 0.702 rs10506348 chr12:57331370 A/G cg14720773 chr17:17603531 RAI1 0.47 6.21 0.36 2.02e-9 Asthma; CESC cis rs2299587 0.897 rs3850744 chr8:17784203 A/G cg08627089 chr8:17753878 FGL1 -0.36 -5.04 -0.3 8.69e-7 Economic and political preferences; CESC cis rs2070488 0.775 rs1073506 chr3:38566235 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.72 -10.94 -0.56 3.14e-23 Electrocardiographic conduction measures; CESC cis rs3733585 0.699 rs6823361 chr4:9963127 A/G cg00071950 chr4:10020882 SLC2A9 -0.73 -11.91 -0.59 1.82e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs34638657 0.673 rs67661146 chr16:82199669 G/A cg09439754 chr16:82129088 HSD17B2 -0.37 -6.42 -0.37 6.31e-10 Lung adenocarcinoma; CESC cis rs1499614 0.522 rs13247442 chr7:66188858 T/C cg13147721 chr7:65941812 NA -0.86 -6.2 -0.36 2.1e-9 Gout; CESC cis rs7089973 0.604 rs11196924 chr10:116571796 A/C cg23260525 chr10:116636907 FAM160B1 -0.35 -6.0 -0.35 6.45e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg10691866 chr7:65817282 TPST1 -0.37 -6.17 -0.35 2.5e-9 Aortic root size; CESC cis rs7666738 0.546 rs10461174 chr4:98698293 G/A cg05340658 chr4:99064831 C4orf37 0.54 6.56 0.37 2.81e-10 Colonoscopy-negative controls vs population controls; CESC cis rs9660992 0.573 rs1172159 chr1:205207512 T/C cg00857998 chr1:205179979 DSTYK 0.56 6.94 0.39 2.95e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs6032067 0.704 rs62208390 chr20:43794844 A/C cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg17949981 chr6:28129498 ZNF389 0.47 5.86 0.34 1.37e-8 Depression; CESC cis rs8060686 0.641 rs8060893 chr16:68191608 A/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.02 -0.35 5.67e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs5757673 1 rs5757673 chr22:39837920 T/C cg24399712 chr22:39784796 NA -0.87 -10.71 -0.55 1.79e-22 Post bronchodilator FEV1; CESC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03142634 chr7:45151369 TBRG4 -0.46 -6.12 -0.35 3.31e-9 Fibrinogen levels; CESC cis rs116095464 0.558 rs62347678 chr5:227496 A/G cg22857025 chr5:266934 NA -1.26 -18.2 -0.75 1.38e-48 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10255097 chr10:114711603 TCF7L2 -0.47 -6.9 -0.39 3.77e-11 Gambling; CESC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg04944784 chr2:26401820 FAM59B -0.96 -10.83 -0.55 7.34e-23 Gut microbiome composition (summer); CESC cis rs6087990 0.735 rs2424922 chr20:31386449 T/C cg13636640 chr20:31349939 DNMT3B 0.8 13.01 0.62 2.87e-30 Ulcerative colitis; CESC cis rs7312774 0.618 rs57361179 chr12:107337483 T/C cg16260113 chr12:107380972 MTERFD3 0.82 7.53 0.42 8.11e-13 Severe influenza A (H1N1) infection; CESC cis rs763014 1.000 rs763014 chr16:675680 T/C cg00802000 chr16:706648 WDR90 -0.43 -6.55 -0.37 2.94e-10 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23428725 chr14:36278532 RALGAPA1 -0.46 -6.2 -0.36 2.14e-9 Gut microbiota (bacterial taxa); CESC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg18876405 chr7:65276391 NA 0.51 5.96 0.34 8.21e-9 Aortic root size; CESC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.15 -0.35 2.85e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11078597 0.614 rs62090057 chr17:1645526 C/T cg18436246 chr17:1640651 WDR81 0.62 7.59 0.42 5.36e-13 Serum albumin level; CESC cis rs6120849 0.707 rs3746444 chr20:33578251 A/G cg24642439 chr20:33292090 TP53INP2 0.67 6.72 0.38 1.12e-10 Protein C levels; CESC cis rs11190604 1.000 rs4919472 chr10:102315864 T/A cg07080220 chr10:102295463 HIF1AN 0.64 6.08 0.35 4.28e-9 Palmitoleic acid (16:1n-7) levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26230390 chr2:203130314 NOP58 0.53 6.2 0.36 2.2e-9 Gut microbiome composition (summer); CESC cis rs7429990 0.965 rs1550914 chr3:47995168 A/C cg11946769 chr3:48343235 NME6 0.45 5.59 0.32 5.78e-8 Educational attainment (years of education); CESC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.7 0.43 2.77e-13 Prudent dietary pattern; CESC cis rs17125944 0.505 rs28568967 chr14:53223060 A/G cg00686598 chr14:53173677 PSMC6 1.35 11.65 0.58 1.3e-25 Alzheimer's disease (late onset); CESC cis rs1153858 1.000 rs1049503 chr15:45653707 T/C cg21132104 chr15:45694354 SPATA5L1 0.85 11.64 0.58 1.47e-25 Homoarginine levels; CESC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg07167872 chr1:205819463 PM20D1 0.75 12.71 0.62 3.22e-29 Menarche (age at onset); CESC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04466995 chr11:65421839 RELA -0.56 -6.73 -0.38 1.05e-10 Gut microbiome composition (summer); CESC cis rs17608059 1.000 rs17608059 chr17:13910549 C/T cg11395062 chr17:14139857 CDRT15 0.5 5.88 0.34 1.23e-8 Temperament; CESC cis rs6430585 0.528 rs309158 chr2:136680534 A/G cg07169764 chr2:136633963 MCM6 1.08 16.51 0.71 1.41e-42 Corneal structure; CESC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg03351412 chr1:154909251 PMVK 0.69 9.38 0.5 3.14e-18 Prostate cancer; CESC cis rs12618769 0.652 rs7595120 chr2:99231805 C/G cg10123293 chr2:99228465 UNC50 0.4 5.27 0.31 2.79e-7 Bipolar disorder; CESC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.66 -0.38 1.57e-10 Parkinson's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26566046 chr12:80083628 PAWR -0.4 -6.25 -0.36 1.64e-9 Gambling; CESC cis rs7640424 0.649 rs35710439 chr3:107913059 C/A cg09227934 chr3:107805635 CD47 -0.45 -5.67 -0.33 3.73e-8 Body mass index; CESC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg00166722 chr3:10149974 C3orf24 0.5 6.2 0.36 2.2e-9 Alzheimer's disease; CESC cis rs2050392 1.000 rs2183176 chr10:30698544 C/T cg18806716 chr10:30721971 MAP3K8 0.43 6.26 0.36 1.51e-9 Inflammatory bowel disease; CESC cis rs1005277 0.540 rs289638 chr10:37923731 G/A cg00409905 chr10:38381863 ZNF37A -0.48 -6.58 -0.37 2.57e-10 Extrinsic epigenetic age acceleration; CESC cis rs854765 0.647 rs2974999 chr17:17997547 T/G cg16928487 chr17:17741425 SREBF1 -0.53 -8.7 -0.47 3.61e-16 Total body bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17882028 chr5:140070892 HARS;HARS2 -0.45 -6.06 -0.35 4.71e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs959260 1.000 rs9909076 chr17:73384809 G/T cg20590849 chr17:73267439 MIF4GD -0.58 -6.86 -0.39 4.77e-11 Systemic lupus erythematosus; CESC trans rs10905099 0.708 rs7084114 chr10:7097364 T/C cg05230642 chr15:25439252 SNORD115-14 -0.73 -6.17 -0.35 2.6e-9 Orofacial clefts; CESC cis rs7542091 0.579 rs34638782 chr1:210032055 C/G cg22029157 chr1:209979665 IRF6 0.36 5.16 0.3 4.8e-7 Monobrow; CESC cis rs7605827 0.930 rs1019358 chr2:15524042 A/G cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs10883723 0.962 rs1056738 chr10:104236481 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.34 0.41 2.67e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs7777754 0.512 rs11238131 chr7:50538589 T/C cg14593290 chr7:50529359 DDC -0.38 -5.38 -0.31 1.61e-7 Response to zileuton treatment in asthma (FEV1 change interaction); CESC cis rs798766 1.000 rs798719 chr4:1698183 C/T cg10756475 chr4:1757242 NA 0.43 5.67 0.33 3.75e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs6088590 1.000 rs6088590 chr20:33313566 T/C cg24642439 chr20:33292090 TP53INP2 0.83 11.61 0.58 1.81e-25 Coronary artery disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07508260 chr11:111742291 ALG9 -0.5 -6.72 -0.38 1.09e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg06873352 chr17:61820015 STRADA 0.48 7.07 0.4 1.37e-11 Height; CESC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12136530 0.593 rs881246 chr1:19733255 C/A cg01832549 chr1:19774989 CAPZB -0.48 -6.33 -0.36 1.05e-9 Lead levels in blood; CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.5 -6.29 -0.36 1.31e-9 Prudent dietary pattern; CESC cis rs2070433 0.559 rs11089057 chr21:47721228 T/A cg12379764 chr21:47803548 PCNT 0.58 6.21 0.36 2.03e-9 Lymphocyte counts; CESC trans rs561341 1.000 rs521919 chr17:30298039 G/T cg27661571 chr11:113659931 NA -0.69 -6.94 -0.39 2.95e-11 Hip circumference adjusted for BMI; CESC cis rs10794720 0.748 rs11250275 chr10:1171823 A/G cg08668510 chr10:1095578 IDI1 -0.68 -5.11 -0.3 6.3e-7 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease; CESC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg21963583 chr11:68658836 MRPL21 0.42 5.75 0.33 2.47e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs75477785 0.590 rs4844938 chr1:210180988 T/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.23 0.36 1.82e-9 Cleft lip with or without cleft palate; CESC cis rs4423214 0.650 rs2186777 chr11:71219803 C/A cg24826892 chr11:71159390 DHCR7 0.5 5.65 0.33 4.07e-8 Vitamin D levels; CESC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg21770322 chr7:97807741 LMTK2 0.58 8.86 0.48 1.18e-16 Prostate cancer (SNP x SNP interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25274881 chr12:49761165 SPATS2 -0.43 -6.08 -0.35 4.16e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs116979167 0.575 rs67661063 chr7:105187259 T/G cg19920283 chr7:105172520 RINT1 0.51 5.8 0.34 1.91e-8 Bipolar disorder (body mass index interaction); CESC cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg03213289 chr20:61660250 NA 0.39 6.16 0.35 2.7e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg06634786 chr22:41940651 POLR3H 0.71 7.03 0.4 1.75e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg00033643 chr7:134001901 SLC35B4 0.42 5.41 0.32 1.41e-7 Mean platelet volume; CESC cis rs765787 0.530 rs28815867 chr15:45526805 G/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg15664640 chr17:80829946 TBCD 0.42 6.07 0.35 4.3e-9 Breast cancer; CESC cis rs11785400 1.000 rs11785400 chr8:143730456 C/T cg24634471 chr8:143751801 JRK 0.45 5.89 0.34 1.15e-8 Schizophrenia; CESC cis rs6032067 0.538 rs6017489 chr20:43731932 C/T cg10761708 chr20:43804764 PI3 0.45 5.22 0.31 3.53e-7 Blood protein levels; CESC cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg11742103 chr11:62369870 EML3;MTA2 0.65 9.8 0.52 1.49e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg19077165 chr18:44547161 KATNAL2 0.6 9.22 0.49 9.27e-18 Personality dimensions; CESC cis rs9486719 0.948 rs2499817 chr6:96878321 C/T cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.73 9.02 0.48 3.82e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Tonsillectomy; CESC cis rs2243480 1.000 rs56016656 chr7:65383481 C/T cg25894440 chr7:65020034 NA -0.62 -5.16 -0.3 4.73e-7 Diabetic kidney disease; CESC cis rs2250402 0.510 rs6492926 chr15:40325829 T/G cg10636054 chr15:40330586 SRP14 1.03 7.47 0.42 1.13e-12 Corneal curvature; CESC cis rs561341 0.714 rs7218466 chr17:30263314 A/G cg00745463 chr17:30367425 LRRC37B -0.48 -5.21 -0.3 3.74e-7 Hip circumference adjusted for BMI; CESC cis rs9623117 1.000 rs6001728 chr22:40434757 A/G cg05033341 chr22:40419857 FAM83F -0.38 -5.03 -0.3 8.97e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs2294693 0.947 rs9349176 chr6:40989525 C/T cg14418226 chr6:40996092 UNC5CL 0.52 6.5 0.37 4.04e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs11711311 0.784 rs13081931 chr3:113349928 G/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.41 5.21 0.3 3.75e-7 IgG glycosylation; CESC cis rs10242455 0.702 rs78218664 chr7:99154381 C/A cg25640893 chr7:99214727 ZNF498 0.79 5.62 0.33 4.84e-8 Blood metabolite levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19138250 chr10:69524126 NA 0.47 6.39 0.37 7.28e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12477438 0.765 rs6754843 chr2:99680485 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs1941023 0.503 rs10750936 chr11:60144180 G/A cg08716584 chr11:60157161 MS4A7 -0.57 -9.51 -0.5 1.18e-18 Congenital heart disease (maternal effect); CESC cis rs7131987 0.903 rs10843367 chr12:29408380 G/A cg09582351 chr12:29534625 ERGIC2 -0.36 -5.67 -0.33 3.66e-8 QT interval; CESC cis rs2115536 1.000 rs7163338 chr15:80198408 C/G cg00225070 chr15:80189496 MTHFS 0.55 7.45 0.42 1.3e-12 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs3749237 0.636 rs1568662 chr3:49521263 A/G cg06212747 chr3:49208901 KLHDC8B 0.48 6.38 0.36 7.79e-10 Resting heart rate; CESC cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg24879335 chr3:133465180 TF 0.45 8.61 0.47 6.73e-16 Iron status biomarkers (transferrin levels); CESC cis rs2882667 0.824 rs13189485 chr5:138475401 C/T cg04439458 chr5:138467593 SIL1 -0.36 -5.52 -0.32 7.93e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7116495 0.609 rs2508860 chr11:71805052 C/T cg26138937 chr11:71823887 C11orf51 1.29 7.99 0.44 4.16e-14 Severe influenza A (H1N1) infection; CESC cis rs727505 0.563 rs73227531 chr7:124800221 T/A cg23710748 chr7:124431027 NA -0.4 -6.13 -0.35 3.13e-9 Lewy body disease; CESC cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg00255919 chr5:131827918 IRF1 -0.57 -9.72 -0.51 2.75e-19 Asthma (sex interaction); CESC trans rs79976124 0.797 rs74995761 chr6:66640216 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 8.29 0.45 5.56e-15 Type 2 diabetes; CESC cis rs2439831 1.000 rs2245054 chr15:43751909 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.57 0.54 5.08e-22 Lung cancer in ever smokers; CESC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg14926445 chr8:58193284 C8orf71 -0.5 -5.38 -0.31 1.62e-7 Developmental language disorder (linguistic errors); CESC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg17179660 chr6:151773299 C6orf211;RMND1 -0.42 -5.45 -0.32 1.13e-7 Menarche (age at onset); CESC cis rs7828089 0.582 rs7825938 chr8:22266866 G/A cg12081754 chr8:22256438 SLC39A14 0.63 8.91 0.48 8.53e-17 Verbal declarative memory; CESC trans rs10002492 0.666 rs1481185 chr4:12580757 A/G cg25106635 chr16:2510001 C16orf59 0.5 6.27 0.36 1.46e-9 IgG glycosylation; CESC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg20744362 chr22:50050164 C22orf34 0.47 8.12 0.45 1.8e-14 Monocyte count;Monocyte percentage of white cells; CESC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg14393609 chr7:65229607 NA -0.47 -6.56 -0.37 2.86e-10 Calcium levels; CESC cis rs6061231 0.544 rs2427314 chr20:60973666 C/T cg22601191 chr20:60968625 CABLES2 0.38 5.2 0.3 4.07e-7 Colorectal cancer; CESC cis rs8014204 0.762 rs10138360 chr14:75293386 A/G cg08847533 chr14:75593920 NEK9 -0.39 -5.06 -0.3 7.94e-7 Caffeine consumption; CESC cis rs7312933 0.558 rs1669886 chr12:42838240 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.5 -6.67 -0.38 1.45e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7833986 0.501 rs2719259 chr8:56941630 A/G cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.27 0.31 2.81e-7 Height; CESC cis rs4253772 0.514 rs11704878 chr22:46714664 C/T cg24881330 chr22:46731750 TRMU 0.79 6.02 0.35 5.79e-9 LDL cholesterol;Cholesterol, total; CESC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg18876405 chr7:65276391 NA -0.57 -7.75 -0.43 1.97e-13 Aortic root size; CESC cis rs2836633 0.929 rs58120977 chr21:40037346 C/T cg12884169 chr21:40033163 ERG 0.39 6.17 0.35 2.53e-9 Coronary artery disease; CESC cis rs11098499 0.644 rs2389880 chr4:120559870 T/A cg09307838 chr4:120376055 NA 0.73 9.59 0.51 7.04e-19 Corneal astigmatism; CESC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg03188948 chr7:1209495 NA 0.7 6.57 0.37 2.65e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs61931739 0.929 rs2389274 chr12:34075149 T/C cg26384229 chr12:38710491 ALG10B -0.47 -6.61 -0.38 2.16e-10 Morning vs. evening chronotype; CESC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.43 -0.37 5.9e-10 Depression; CESC cis rs3820928 0.904 rs4129884 chr2:227820943 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.68 -0.33 3.57e-8 Pulmonary function; CESC cis rs6840258 1.000 rs56201818 chr4:87952633 T/C cg08197287 chr4:87952173 AFF1 -0.39 -5.3 -0.31 2.39e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs910316 0.783 rs11850751 chr14:75590113 A/T cg08847533 chr14:75593920 NEK9 1.0 18.45 0.75 1.83e-49 Height; CESC cis rs2425143 0.915 rs74355238 chr20:34441541 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.67 6.06 0.35 4.6e-9 Blood protein levels; CESC cis rs34779708 0.931 rs11010083 chr10:35351531 C/G cg04310649 chr10:35416472 CREM -0.52 -6.21 -0.36 2.07e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs3749237 0.557 rs7631908 chr3:49425707 T/G cg02487422 chr3:49467188 NICN1 0.55 7.99 0.44 4.23e-14 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04217776 chr1:173794059 CENPL;DARS2 0.58 6.15 0.35 2.78e-9 Gut microbiome composition (summer); CESC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg23283495 chr1:209979779 IRF6 0.55 6.3 0.36 1.24e-9 Cleft lip with or without cleft palate; CESC trans rs1814175 0.803 rs11040451 chr11:49650639 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -17.65 -0.74 1.25e-46 Height; CESC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg02269571 chr22:50332266 NA -0.52 -6.56 -0.37 2.88e-10 Schizophrenia; CESC cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg05776053 chr2:74358815 NA 0.41 5.12 0.3 5.76e-7 Gestational age at birth (maternal effect); CESC cis rs10208940 0.920 rs12713643 chr2:68724129 C/G cg12452813 chr2:68675892 NA 0.52 5.24 0.31 3.26e-7 Urate levels in lean individuals; CESC cis rs9583531 0.600 rs9555724 chr13:111354110 C/T cg15841412 chr13:111365552 ING1 -0.44 -5.96 -0.34 8.22e-9 Coronary artery disease; CESC trans rs7824557 0.564 rs2736293 chr8:11234613 T/A cg06636001 chr8:8085503 FLJ10661 -0.48 -6.0 -0.35 6.44e-9 Retinal vascular caliber; CESC cis rs9911578 0.692 rs412000 chr17:56709058 G/C cg05425664 chr17:57184151 TRIM37 -0.4 -5.47 -0.32 1.05e-7 Intelligence (multi-trait analysis); CESC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 9.66 0.51 4.01e-19 Platelet count; CESC cis rs4911259 0.533 rs6058931 chr20:31471012 C/T cg13636640 chr20:31349939 DNMT3B -0.51 -6.94 -0.39 3.05e-11 Inflammatory bowel disease; CESC cis rs11166629 1.000 rs894349 chr8:135638055 T/C cg27224718 chr8:135614730 ZFAT 0.55 6.77 0.38 8.28e-11 Smoking quantity; CESC cis rs9303401 0.580 rs12603808 chr17:56578508 T/G cg10487724 chr17:56770010 TEX14;RAD51C 0.98 10.76 0.55 1.19e-22 Cognitive test performance; CESC cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg08645402 chr16:4508243 NA 0.44 6.43 0.37 5.76e-10 Schizophrenia; CESC cis rs2072732 0.861 rs67289919 chr1:2954208 G/A cg15211996 chr1:2936768 ACTRT2 0.34 6.04 0.35 5.27e-9 Plateletcrit; CESC cis rs9908102 0.740 rs73981621 chr17:12914832 C/T cg26162695 chr17:12921313 ELAC2 0.52 5.67 0.33 3.69e-8 Schizophrenia; CESC cis rs1728785 1.000 rs1728780 chr16:68567642 G/C cg02972257 chr16:68554789 NA -0.55 -6.36 -0.36 8.6e-10 Ulcerative colitis; CESC cis rs57502260 0.704 rs72936570 chr11:68307139 A/G cg20283391 chr11:68216788 NA -0.71 -5.78 -0.33 2.1e-8 Total body bone mineral density (age 45-60); CESC cis rs561341 1.000 rs530209 chr17:30315287 A/G cg00745463 chr17:30367425 LRRC37B -0.78 -7.09 -0.4 1.2e-11 Hip circumference adjusted for BMI; CESC cis rs3096299 0.933 rs2965939 chr16:89493043 G/A cg08392591 chr16:89556376 ANKRD11 0.47 6.04 0.35 5.28e-9 Multiple myeloma (IgH translocation); CESC cis rs1878931 0.580 rs7194596 chr16:3404408 T/A cg00484396 chr16:3507460 NAT15 -0.36 -5.54 -0.32 7.37e-8 Body mass index (adult); CESC cis rs10129255 0.518 rs12590732 chr14:107187851 C/T cg23076370 chr14:107095027 NA 0.65 9.84 0.52 1.14e-19 Kawasaki disease; CESC cis rs1003719 0.715 rs2835649 chr21:38552230 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.38 0.46 3.2e-15 Eye color traits; CESC cis rs858239 0.539 rs6461694 chr7:23187779 G/A cg23682824 chr7:23144976 KLHL7 0.46 5.85 0.34 1.45e-8 Cerebrospinal fluid biomarker levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25346720 chr7:73184981 CLDN3 0.56 6.33 0.36 1.07e-9 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg17949981 chr6:28129498 ZNF389 0.45 5.49 0.32 9.35e-8 Depression; CESC cis rs17826219 0.706 rs8075107 chr17:29106649 C/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24512544 chr8:141588943 EIF2C2 0.5 6.77 0.38 8.14e-11 Fibrinogen levels; CESC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg15352829 chr14:105391018 PLD4 -0.6 -10.53 -0.54 6.87e-22 Rheumatoid arthritis; CESC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1577917 1.000 rs12199784 chr6:86726808 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.03 -0.35 5.34e-9 Response to antipsychotic treatment; CESC cis rs7582720 1.000 rs79642273 chr2:203830851 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs2710642 0.815 rs6545971 chr2:63074986 A/T cg17519650 chr2:63277830 OTX1 0.59 7.72 0.43 2.4e-13 LDL cholesterol levels;LDL cholesterol; CESC cis rs6952808 0.931 rs12537430 chr7:1868761 A/G cg23102388 chr7:1867652 MAD1L1 0.36 5.54 0.32 7.34e-8 Bipolar disorder and schizophrenia; CESC cis rs889398 0.802 rs8050414 chr16:69886813 T/A cg09409435 chr16:70099608 PDXDC2 0.41 5.07 0.3 7.55e-7 Body mass index; CESC cis rs7208859 0.673 rs73265624 chr17:29232066 G/A cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs68170813 0.559 rs76843318 chr7:106863173 A/G cg02696742 chr7:106810147 HBP1 -0.52 -5.09 -0.3 6.89e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12066592 chr14:34931026 C14orf147 0.55 6.1 0.35 3.68e-9 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs4821810 chr22:39072098 C/G cg21395723 chr22:39101663 GTPBP1 0.49 6.73 0.38 1.07e-10 Menopause (age at onset); CESC cis rs1670533 1.000 rs6857085 chr4:1095920 C/A cg04106633 chr4:1044584 NA -0.4 -5.18 -0.3 4.5e-7 Recombination rate (females); CESC cis rs2228479 0.681 rs4287569 chr16:89957815 A/G cg04013166 chr16:89971882 TCF25 0.72 8.95 0.48 6.37e-17 Skin colour saturation; CESC cis rs4148883 0.645 rs2851264 chr4:100029715 C/T cg13256891 chr4:100009986 ADH5 0.54 7.11 0.4 1.07e-11 Alcohol dependence; CESC cis rs858239 0.670 rs3807452 chr7:23162081 C/T cg27449745 chr7:23145252 KLHL7 0.49 6.63 0.38 1.9e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7726839 0.507 rs56282020 chr5:596701 T/C cg16447950 chr5:562315 NA -0.59 -6.01 -0.35 6.18e-9 Obesity-related traits; CESC cis rs2228479 0.867 rs57492102 chr16:89975572 A/G cg04013166 chr16:89971882 TCF25 0.7 6.91 0.39 3.7e-11 Skin colour saturation; CESC cis rs8114671 0.839 rs6142290 chr20:33654672 A/C cg24642439 chr20:33292090 TP53INP2 -0.47 -5.7 -0.33 3.19e-8 Height; CESC cis rs17253792 0.822 rs75991559 chr14:56092419 A/T cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs826838 0.967 rs1719852 chr12:39128531 A/G cg13010199 chr12:38710504 ALG10B -0.44 -5.97 -0.34 7.74e-9 Heart rate; CESC cis rs13102973 0.864 rs7442176 chr4:135899575 C/A cg14419869 chr4:135874104 NA -0.34 -5.18 -0.3 4.49e-7 Subjective well-being; CESC cis rs1178968 1.000 rs757938 chr7:72778573 A/G cg25889504 chr7:72793014 NA 0.49 5.26 0.31 2.91e-7 Triglyceride levels; CESC cis rs12497850 0.931 rs4974082 chr3:48999323 G/A cg02487422 chr3:49467188 NICN1 0.43 5.53 0.32 7.78e-8 Parkinson's disease; CESC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg09509183 chr1:209979624 IRF6 0.47 5.9 0.34 1.08e-8 Cleft lip with or without cleft palate; CESC cis rs9858542 1.000 rs13316695 chr3:49684917 C/G cg03060546 chr3:49711283 APEH -0.59 -6.94 -0.39 2.96e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs3733585 0.699 rs7657340 chr4:9966772 A/T cg00071950 chr4:10020882 SLC2A9 -0.7 -11.44 -0.57 6.82e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9921222 0.509 rs3743883 chr16:404750 T/C cg26944245 chr16:421049 TMEM8A;MRPL28 0.48 7.75 0.43 1.99e-13 Bone mineral density (spine);Bone mineral density; CESC trans rs7246760 0.867 rs61011126 chr19:9814421 A/C cg02900749 chr2:68251473 NA -0.86 -7.65 -0.43 3.79e-13 Pursuit maintenance gain; CESC cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg15921436 chr17:44337874 NA 0.78 9.07 0.49 2.84e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6691722 0.583 rs7532539 chr1:24694427 A/G cg02336364 chr1:24764700 NIPAL3 0.28 5.68 0.33 3.59e-8 Response to interferon beta in multiple sclerosis; CESC cis rs11240408 1 rs11240408 chr1:205264536 A/T cg21643547 chr1:205240462 TMCC2 0.51 7.47 0.42 1.14e-12 Platelet count; CESC cis rs2050392 0.517 rs603072 chr10:30755778 C/T cg18806716 chr10:30721971 MAP3K8 0.53 8.06 0.44 2.57e-14 Inflammatory bowel disease; CESC cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg05340658 chr4:99064831 C4orf37 0.81 12.43 0.61 3.07e-28 Colonoscopy-negative controls vs population controls; CESC cis rs8092503 1.000 rs11152003 chr18:52476469 A/G cg12377874 chr18:52495404 RAB27B 0.38 6.27 0.36 1.46e-9 Childhood body mass index; CESC cis rs17818399 0.533 rs4384837 chr2:46789514 A/G cg02822958 chr2:46747628 ATP6V1E2 0.41 5.3 0.31 2.44e-7 Height; CESC cis rs11098499 0.863 rs3822194 chr4:120471648 A/G cg09307838 chr4:120376055 NA 0.9 12.48 0.61 1.95e-28 Corneal astigmatism; CESC cis rs9359856 0.564 rs72915946 chr6:90447924 C/T cg13799429 chr6:90582589 CASP8AP2 -0.61 -5.59 -0.32 5.75e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21521250 chr18:43753889 C18orf25 0.53 6.02 0.35 5.8e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs11725477 chr4:98803266 G/T cg24818145 chr4:99064322 C4orf37 0.4 5.18 0.3 4.34e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1801251 1.000 rs283469 chr2:233656997 G/T cg08000102 chr2:233561755 GIGYF2 0.66 9.49 0.5 1.46e-18 Coronary artery disease; CESC cis rs6120849 0.754 rs6120790 chr20:33599090 A/T cg06115741 chr20:33292138 TP53INP2 0.53 5.11 0.3 6.15e-7 Protein C levels; CESC cis rs2070488 0.766 rs6808093 chr3:38498160 T/C cg24069376 chr3:38537580 EXOG 0.33 5.59 0.32 5.58e-8 Electrocardiographic conduction measures; CESC cis rs4242434 0.854 rs4872007 chr8:22538879 G/A cg03733263 chr8:22462867 KIAA1967 -0.94 -13.23 -0.63 5.15e-31 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs9818758 0.607 rs67060340 chr3:48915321 C/T cg00383909 chr3:49044727 WDR6 0.9 6.78 0.38 7.86e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs12900413 0.687 rs13343248 chr15:90311226 A/T cg24249390 chr15:90295951 MESP1 -0.4 -5.5 -0.32 9.05e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs11166629 1.000 rs2315838 chr8:135645968 C/T cg27224718 chr8:135614730 ZFAT 0.49 6.3 0.36 1.26e-9 Smoking quantity; CESC cis rs6460942 0.555 rs7803268 chr7:12306793 G/A cg10578991 chr7:12443926 VWDE -0.59 -6.16 -0.35 2.63e-9 Coronary artery disease; CESC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.08 10.67 0.55 2.41e-22 Platelet count; CESC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg05754148 chr16:3507555 NAT15 0.57 8.57 0.47 8.86e-16 Tuberculosis; CESC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg07157834 chr1:205819609 PM20D1 0.72 11.05 0.56 1.35e-23 Menarche (age at onset); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg19586661 chr11:66079705 NA 0.45 6.13 0.35 3.11e-9 Bronchopulmonary dysplasia; CESC cis rs4909189 1.000 rs62493649 chr7:158135556 C/G cg06219351 chr7:158114137 PTPRN2 -0.6 -8.1 -0.45 2e-14 Response to amphetamines; CESC cis rs2011503 1.000 rs45631651 chr19:19638743 A/G cg11584989 chr19:19387371 SF4 0.61 7.03 0.4 1.79e-11 Bipolar disorder; CESC cis rs2839186 0.933 rs4818832 chr21:47708634 C/T cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 7.02e-11 Testicular germ cell tumor; CESC cis rs2839186 0.706 rs2839188 chr21:47692798 C/T cg13012494 chr21:47604986 C21orf56 0.45 5.64 0.33 4.32e-8 Testicular germ cell tumor; CESC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg05535760 chr7:792225 HEATR2 -0.39 -5.03 -0.3 9.07e-7 Perceived unattractiveness to mosquitoes; CESC cis rs2204008 0.522 rs117743143 chr12:38030824 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.63 0.42 4.16e-13 Bladder cancer; CESC cis rs1878931 0.501 rs28735976 chr16:3418419 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.77 10.42 0.54 1.58e-21 Body mass index (adult); CESC cis rs7605827 0.930 rs11893272 chr2:15613796 C/T cg19274914 chr2:15703543 NA 0.38 6.75 0.38 9.33e-11 Educational attainment (years of education); CESC cis rs7923609 0.967 rs2393966 chr10:65134814 T/G cg01631684 chr10:65280961 REEP3 -0.42 -5.18 -0.3 4.35e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7527798 0.592 rs6657161 chr1:207847128 C/T cg21110645 chr1:207815933 NA -0.33 -5.63 -0.33 4.66e-8 Erythrocyte sedimentation rate; CESC cis rs72627123 0.656 rs4646864 chr14:74526703 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.36 0.31 1.81e-7 Morning vs. evening chronotype; CESC cis rs2735413 0.875 rs8053987 chr16:78084834 G/A cg04733911 chr16:78082701 NA 0.54 9.15 0.49 1.57e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7208859 0.673 rs450585 chr17:28951039 G/A cg17105886 chr17:28927953 LRRC37B2 0.61 5.44 0.32 1.19e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs911555 0.692 rs7145753 chr14:103866100 G/A cg12935359 chr14:103987150 CKB 0.59 8.63 0.47 5.97e-16 Intelligence (multi-trait analysis); CESC cis rs3733585 0.699 rs12498956 chr4:9950705 G/T cg02734326 chr4:10020555 SLC2A9 -0.4 -5.68 -0.33 3.49e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.69 0.38 1.3e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs72634258 0.842 rs6577463 chr1:8169485 T/G cg00042356 chr1:8021962 PARK7 -0.56 -5.99 -0.35 6.97e-9 Inflammatory bowel disease; CESC cis rs258324 0.790 rs2162944 chr16:89717670 G/C cg04240660 chr16:89714849 CHMP1A -0.55 -5.3 -0.31 2.39e-7 Height; CESC cis rs35146811 0.807 rs10228764 chr7:99608029 A/G cg14163444 chr7:99595348 NA -0.39 -5.14 -0.3 5.32e-7 Coronary artery disease; CESC cis rs9549260 0.564 rs7998086 chr13:41268924 T/C cg21288729 chr13:41239152 FOXO1 0.58 7.43 0.42 1.48e-12 Red blood cell count; CESC cis rs963731 0.579 rs2168042 chr2:39273536 C/T cg04010122 chr2:39346883 SOS1 -0.68 -5.33 -0.31 2.1e-7 Corticobasal degeneration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04738447 chr16:708575 WDR90 -0.58 -6.31 -0.36 1.14e-9 Gut microbiome composition (summer); CESC cis rs1707322 0.896 rs946528 chr1:46485562 C/T cg03146154 chr1:46216737 IPP -0.71 -9.65 -0.51 4.43e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3820068 0.603 rs59558854 chr1:15971399 T/G cg17385448 chr1:15911702 AGMAT 0.42 6.75 0.38 9.26e-11 Systolic blood pressure; CESC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg16325326 chr1:53192061 ZYG11B -0.54 -8.02 -0.44 3.49e-14 Monocyte count; CESC cis rs2228479 0.850 rs17226666 chr16:89835401 G/A cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg11644478 chr21:40555479 PSMG1 0.96 13.84 0.65 3.74e-33 Cognitive function; CESC cis rs7107174 1.000 rs2292573 chr11:78053139 A/G cg02023728 chr11:77925099 USP35 0.38 5.4 0.31 1.47e-7 Testicular germ cell tumor; CESC cis rs684232 0.602 rs331014 chr17:532103 C/T cg12384639 chr17:618140 VPS53 0.41 5.31 0.31 2.36e-7 Prostate cancer; CESC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg05861140 chr6:150128134 PCMT1 -0.38 -5.43 -0.32 1.29e-7 Lung cancer; CESC cis rs72781680 0.898 rs72780123 chr2:23996009 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs2242194 0.816 rs6671688 chr1:154994265 T/C cg09359103 chr1:154839909 KCNN3 -0.41 -6.62 -0.38 2.01e-10 Schizophrenia; CESC cis rs9937943 0.667 rs35126294 chr16:74651005 T/C cg01733217 chr16:74700730 RFWD3 0.6 5.64 0.33 4.45e-8 Neutrophil percentage of white cells; CESC cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg00149659 chr3:10157352 C3orf10 0.95 11.38 0.57 1.05e-24 Alzheimer's disease; CESC cis rs3733585 0.673 rs6840802 chr4:9965633 C/G cg00071950 chr4:10020882 SLC2A9 0.73 11.3 0.57 1.93e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09744376 chr3:53080176 SFMBT1 -0.43 -6.05 -0.35 4.83e-9 Fibrinogen levels; CESC cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg18230493 chr5:56204884 C5orf35 0.68 7.88 0.44 8.77e-14 Initial pursuit acceleration; CESC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg05564831 chr3:52568323 NT5DC2 0.44 6.83 0.39 5.68e-11 Bipolar disorder; CESC cis rs3540 0.554 rs12443252 chr15:91064690 C/T cg10434728 chr15:90938212 IQGAP1 -0.41 -7.07 -0.4 1.37e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs11764590 0.715 rs11760737 chr7:2104055 T/C cg11693508 chr17:37793320 STARD3 0.67 6.38 0.36 8.07e-10 Neuroticism; CESC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg08027265 chr7:2291960 NA -0.33 -5.06 -0.3 7.8e-7 Bipolar disorder and schizophrenia; CESC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg01939980 chr4:1354348 KIAA1530 0.43 5.08 0.3 7e-7 Longevity; CESC cis rs1421811 0.606 rs981001 chr5:32721545 G/A cg16267343 chr5:32710456 NPR3 0.54 5.85 0.34 1.42e-8 Blood pressure; CESC cis rs5758659 0.652 rs5758553 chr22:42431429 G/A cg05082376 chr22:42548792 NA -0.38 -5.59 -0.32 5.78e-8 Cognitive function; CESC cis rs1005277 0.540 rs1987431 chr10:37988887 T/C cg00409905 chr10:38381863 ZNF37A -0.51 -7.12 -0.4 9.95e-12 Extrinsic epigenetic age acceleration; CESC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg02725872 chr8:58115012 NA -0.41 -5.82 -0.34 1.69e-8 Developmental language disorder (linguistic errors); CESC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg18876405 chr7:65276391 NA -0.52 -7.03 -0.4 1.71e-11 Aortic root size; CESC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.53 -7.07 -0.4 1.35e-11 Menarche (age at onset); CESC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg00149659 chr3:10157352 C3orf10 0.63 6.44 0.37 5.66e-10 Alzheimer's disease; CESC cis rs7762018 1.000 rs73242927 chr6:170129573 T/A cg05834625 chr6:170176447 C6orf70 0.66 7.76 0.43 1.9e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs8180040 0.654 rs11714373 chr3:47214817 G/A cg27129171 chr3:47204927 SETD2 -0.68 -9.97 -0.52 4.2e-20 Colorectal cancer; CESC cis rs9616064 0.506 rs2073275 chr22:47070432 G/C cg05621596 chr22:47072043 GRAMD4 -0.74 -11.13 -0.56 7.47e-24 Urate levels in obese individuals; CESC cis rs2658782 0.756 rs3019223 chr11:93084182 G/A cg15737290 chr11:93063684 CCDC67 0.59 7.43 0.42 1.52e-12 Pulmonary function decline; CESC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg11764359 chr7:65958608 NA -0.78 -11.64 -0.58 1.45e-25 Aortic root size; CESC cis rs8072100 0.713 rs8074451 chr17:45477573 C/T cg08085267 chr17:45401833 C17orf57 -0.53 -6.64 -0.38 1.77e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs3768617 0.565 rs10752901 chr1:183089327 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.49 0.64 6.22e-32 Fuchs's corneal dystrophy; CESC cis rs9303401 0.614 rs8081058 chr17:57160513 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.92 11.49 0.58 4.47e-25 Cognitive test performance; CESC cis rs796364 0.789 rs176008 chr2:200814720 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.89 8.87 0.48 1.08e-16 Schizophrenia; CESC cis rs12220238 1.000 rs10824098 chr10:75943579 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.75 0.33 2.43e-8 Soluble interleukin-2 receptor subunit alpha; CESC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg11764359 chr7:65958608 NA 0.81 11.74 0.58 6.73e-26 Aortic root size; CESC cis rs898097 0.841 rs8180 chr17:80901036 C/G cg05255149 chr17:80675120 FN3KRP 0.45 5.39 0.31 1.58e-7 Breast cancer; CESC cis rs2228479 0.867 rs2270459 chr16:89979851 A/C cg06558623 chr16:89946397 TCF25 -0.87 -8.01 -0.44 3.6e-14 Skin colour saturation; CESC cis rs6691722 0.503 rs4140519 chr1:24708304 C/T cg02336364 chr1:24764700 NIPAL3 0.32 6.55 0.37 2.91e-10 Response to interferon beta in multiple sclerosis; CESC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg07507251 chr3:52567010 NT5DC2 0.32 5.56 0.32 6.75e-8 Bipolar disorder; CESC cis rs870825 0.616 rs7674952 chr4:185622327 A/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs854765 0.647 rs854767 chr17:18018263 A/C cg16928487 chr17:17741425 SREBF1 0.45 7.11 0.4 1.07e-11 Total body bone mineral density; CESC cis rs7520050 0.931 rs6688365 chr1:46329884 G/C cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.4e-7 Red blood cell count;Reticulocyte count; CESC trans rs12891047 1.000 rs7160196 chr14:68265744 C/T cg12499123 chr5:10250085 CCT5;FAM173B 0.51 6.06 0.35 4.6e-9 Amyotrophic lateral sclerosis (sporadic); CESC trans rs1814175 0.645 rs1721996 chr11:49915527 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg08027265 chr7:2291960 NA -0.39 -5.87 -0.34 1.29e-8 Bipolar disorder and schizophrenia; CESC cis rs67311347 1.000 rs9842564 chr3:40405810 A/G cg24209194 chr3:40518798 ZNF619 -0.45 -5.81 -0.34 1.76e-8 Renal cell carcinoma; CESC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg09359103 chr1:154839909 KCNN3 0.66 12.27 0.6 1.03e-27 Prostate cancer; CESC cis rs6964587 1.000 rs10245095 chr7:91710845 A/G cg17063962 chr7:91808500 NA 0.55 7.68 0.43 3.06e-13 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03779880 chr21:44395779 PKNOX1 0.61 7.12 0.4 1.01e-11 Gut microbiome composition (summer); CESC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg24846343 chr22:24311635 DDTL -0.48 -7.69 -0.43 2.98e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4805272 0.512 rs4805279 chr19:29336966 A/G cg12756686 chr19:29218302 NA 0.41 5.32 0.31 2.17e-7 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs11098499 0.754 rs878376 chr4:120237702 G/A cg09307838 chr4:120376055 NA 0.81 10.96 0.56 2.61e-23 Corneal astigmatism; CESC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg17376030 chr22:41985996 PMM1 -0.78 -8.23 -0.45 8.32e-15 Vitiligo; CESC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg09877947 chr5:131593287 PDLIM4 0.47 6.15 0.35 2.86e-9 Breast cancer; CESC cis rs796364 0.806 rs74266490 chr2:201005995 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -6.48 -0.37 4.47e-10 Schizophrenia; CESC trans rs208520 0.633 rs7738469 chr6:66807446 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.78 -0.62 1.78e-29 Exhaled nitric oxide output; CESC cis rs2070488 0.931 rs6599212 chr3:38558906 T/C cg24069376 chr3:38537580 EXOG -0.46 -8.45 -0.46 1.91e-15 Electrocardiographic conduction measures; CESC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg23978390 chr7:1156363 C7orf50 0.47 6.41 0.37 6.75e-10 Longevity;Endometriosis; CESC cis rs1691799 0.899 rs1168329 chr12:66731864 C/A cg16791601 chr12:66731901 HELB -0.79 -14.29 -0.66 9.69e-35 White blood cell count (basophil); CESC cis rs60871478 1.000 rs7795258 chr7:795227 A/G cg05535760 chr7:792225 HEATR2 0.85 10.7 0.55 1.91e-22 Cerebrospinal P-tau181p levels; CESC cis rs9300255 0.550 rs10772997 chr12:123719880 C/A cg19016782 chr12:123741754 C12orf65 -0.36 -5.3 -0.31 2.45e-7 Neutrophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03353863 chr19:52618714 ZNF616 0.48 6.04 0.35 5.14e-9 Fibrinogen levels; CESC cis rs9291683 0.588 rs34501273 chr4:9996996 C/T cg11266682 chr4:10021025 SLC2A9 0.66 13.36 0.63 1.79e-31 Bone mineral density; CESC cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7937682 0.889 rs10749984 chr11:111492861 T/C cg09085632 chr11:111637200 PPP2R1B -0.95 -14.6 -0.67 8.26e-36 Primary sclerosing cholangitis; CESC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg27266027 chr21:40555129 PSMG1 0.43 5.11 0.3 6.04e-7 Cognitive function; CESC cis rs3015497 0.603 rs2356453 chr14:51049648 C/T cg26011998 chr14:51135199 SAV1 -0.46 -5.25 -0.31 3.2e-7 Mean platelet volume; CESC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg21724239 chr8:58056113 NA 0.6 5.56 0.32 6.59e-8 Developmental language disorder (linguistic errors); CESC cis rs115344852 0.598 rs2191035 chr6:28434943 A/G cg14547644 chr6:28411285 ZSCAN23 -0.32 -5.07 -0.3 7.31e-7 Epithelial ovarian cancer; CESC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.95 14.87 0.67 9.16e-37 Prudent dietary pattern; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10044839 chr6:13487863 GFOD1;C6orf114 -0.51 -6.4 -0.37 7.07e-10 Ulcerative colitis; CESC cis rs698813 0.763 rs786615 chr2:44590608 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.9 0.34 1.1e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs778371 0.522 rs10205801 chr2:233597196 G/A cg08000102 chr2:233561755 GIGYF2 0.8 13.08 0.63 1.72e-30 Schizophrenia; CESC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg25036284 chr2:26402008 FAM59B -0.74 -8.4 -0.46 2.72e-15 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23540748 chr19:8455165 RAB11B 0.56 6.27 0.36 1.44e-9 Gut microbiome composition (summer); CESC cis rs826838 0.967 rs11183022 chr12:38652519 G/A cg13010199 chr12:38710504 ALG10B 0.59 8.31 0.45 4.93e-15 Heart rate; CESC trans rs61931739 0.500 rs11053189 chr12:34433455 G/A cg13010199 chr12:38710504 ALG10B 0.49 6.3 0.36 1.24e-9 Morning vs. evening chronotype; CESC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg08968635 chr6:28129556 ZNF389 0.41 5.53 0.32 7.61e-8 Depression; CESC cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg03433033 chr1:76189801 ACADM 0.71 9.78 0.52 1.68e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1003719 0.715 rs2835639 chr21:38537016 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.98 -0.44 4.49e-14 Eye color traits; CESC trans rs7839040 0.698 rs7825067 chr8:82929707 T/C cg14472086 chr9:107730925 NA -0.48 -6.33 -0.36 1.03e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs35306767 0.951 rs55742421 chr10:961037 A/C cg26597838 chr10:835615 NA 0.98 10.69 0.55 2.06e-22 Eosinophil percentage of granulocytes; CESC cis rs7208859 0.623 rs9897728 chr17:29108804 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg05368731 chr17:41323189 NBR1 0.78 11.15 0.57 6.28e-24 Menopause (age at onset); CESC cis rs7193541 0.684 rs9929496 chr16:74668473 G/A cg05580060 chr16:74700937 RFWD3 -0.48 -6.26 -0.36 1.57e-9 Multiple myeloma; CESC cis rs9611565 0.729 rs505533 chr22:41864216 A/C cg06634786 chr22:41940651 POLR3H 0.45 5.31 0.31 2.3e-7 Vitiligo; CESC cis rs2243480 1.000 rs35735127 chr7:65300423 G/T cg18252515 chr7:66147081 NA -1.01 -9.72 -0.51 2.6e-19 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00861839 chr18:23670297 SS18 -0.55 -6.27 -0.36 1.48e-9 Gut microbiome composition (summer); CESC cis rs911555 0.655 rs10141157 chr14:104018105 T/C cg24130564 chr14:104152367 KLC1 -0.58 -8.27 -0.45 6.5e-15 Intelligence (multi-trait analysis); CESC cis rs9787249 0.957 rs11206754 chr1:40216234 A/G cg19912559 chr1:40204330 PPIE 0.44 6.76 0.38 8.9e-11 Blood protein levels; CESC cis rs738322 0.935 rs133014 chr22:38571087 T/G cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC cis rs4919044 0.688 rs59539045 chr10:94776594 C/A cg16508068 chr10:94451736 HHEX -0.5 -5.49 -0.32 9.61e-8 Coronary artery disease; CESC cis rs9549367 0.789 rs2302757 chr13:113909339 A/G cg00898013 chr13:113819073 PROZ -0.56 -7.74 -0.43 2.08e-13 Platelet distribution width; CESC trans rs877282 0.755 rs2486579 chr10:785647 G/A cg22713356 chr15:30763199 NA 1.09 11.81 0.59 3.82e-26 Uric acid levels; CESC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg06873352 chr17:61820015 STRADA 0.71 12.16 0.6 2.5e-27 Prudent dietary pattern; CESC trans rs89107 0.549 rs4945623 chr6:118980556 G/C cg15017278 chr16:127449 MPG -0.32 -6.0 -0.35 6.53e-9 Cardiac structure and function; CESC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg09365446 chr1:150670422 GOLPH3L 0.39 5.13 0.3 5.7e-7 Melanoma; CESC cis rs2294693 0.945 rs9369252 chr6:40986028 C/T cg14418226 chr6:40996092 UNC5CL -0.57 -6.67 -0.38 1.48e-10 Gastric cancer;Non-cardia gastric cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14136810 chr15:40213326 GPR176 0.55 6.52 0.37 3.49e-10 Gut microbiome composition (summer); CESC cis rs7317038 0.745 rs75590443 chr13:114015421 A/T cg24344662 chr13:114018021 GRTP1 -0.5 -6.19 -0.36 2.27e-9 Mean platelet volume; CESC cis rs4919087 0.923 rs11189037 chr10:98974707 C/G cg25902810 chr10:99078978 FRAT1 0.67 9.67 0.51 3.88e-19 Monocyte count; CESC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg06713675 chr4:122721982 EXOSC9 -0.51 -7.02 -0.4 1.9e-11 Type 2 diabetes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05205664 chr11:73694566 UCP2 -0.46 -6.11 -0.35 3.47e-9 Asthma; CESC cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg17143192 chr8:8559678 CLDN23 -0.42 -5.03 -0.3 9.02e-7 Mood instability; CESC trans rs1223629 1.000 rs11187800 chr10:95936892 A/G cg16346422 chr11:2920819 SLC22A18;SLC22A18AS 0.67 6.02 0.35 5.67e-9 Glucose homeostasis traits; CESC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.6 0.33 5.36e-8 Menopause (age at onset); CESC cis rs7208859 0.673 rs11650305 chr17:29229361 A/C cg19761014 chr17:28927070 LRRC37B2 0.64 5.32 0.31 2.2e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6073597 1.000 rs6031980 chr20:43714384 C/T cg26270411 chr20:43514327 YWHAB -0.35 -5.08 -0.3 7.27e-7 Positive affect; CESC cis rs116095464 0.558 rs9312977 chr5:221916 G/C cg22496380 chr5:211416 CCDC127 -0.72 -8.57 -0.47 8.59e-16 Breast cancer; CESC cis rs3768617 0.510 rs6666259 chr1:183102855 T/C ch.1.3577855R chr1:183094577 LAMC1 0.88 14.27 0.66 1.19e-34 Fuchs's corneal dystrophy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14405528 chr22:47372700 TBC1D22A 0.49 6.57 0.37 2.59e-10 Fibrinogen levels; CESC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg17143192 chr8:8559678 CLDN23 0.74 8.83 0.48 1.51e-16 Obesity-related traits; CESC cis rs9549367 0.774 rs9549696 chr13:113875062 C/T cg18105134 chr13:113819100 PROZ -0.69 -8.91 -0.48 8.28e-17 Platelet distribution width; CESC cis rs1775715 0.870 rs1615256 chr10:32254101 T/C cg04359828 chr10:32216031 ARHGAP12 0.35 5.17 0.3 4.72e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs8114671 0.662 rs3761143 chr20:33545745 C/T cg07148914 chr20:33460835 GGT7 0.42 5.38 0.31 1.64e-7 Height; CESC cis rs2718058 0.639 rs2597270 chr7:37762014 A/G cg15028436 chr7:37888078 TXNDC3 -0.44 -6.24 -0.36 1.69e-9 Alzheimer's disease (late onset); CESC cis rs425277 1.000 rs262654 chr1:2089526 G/A cg16545954 chr1:2118288 C1orf86 0.33 5.52 0.32 7.93e-8 Height; CESC cis rs3931020 0.508 rs4145871 chr1:75218704 C/T cg10128416 chr1:75198403 TYW3;CRYZ 0.44 5.34 0.31 1.97e-7 Resistin levels; CESC cis rs8042849 1 rs8042849 chr15:78817929 C/T cg18825076 chr15:78729989 IREB2 0.43 5.58 0.32 5.91e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Parental lifespan;Post bronchodilator FEV1/FVC ratio in COPD; CESC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg22823121 chr1:150693482 HORMAD1 0.36 5.1 0.3 6.36e-7 Melanoma; CESC cis rs9614461 0.826 rs9614649 chr22:45746097 C/A cg01808030 chr22:45809952 RIBC2;SMC1B 0.67 7.24 0.41 4.83e-12 Tonsillectomy; CESC trans rs7824557 0.527 rs4631425 chr8:11239054 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.23 -0.36 1.83e-9 Retinal vascular caliber; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07580707 chr3:14220061 XPC;LSM3 0.56 6.71 0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs12476592 0.571 rs10171223 chr2:63687700 A/G cg17519650 chr2:63277830 OTX1 -0.48 -5.41 -0.32 1.39e-7 Childhood ear infection; CESC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.47 -0.37 4.81e-10 Life satisfaction; CESC cis rs739401 0.611 rs450817 chr11:3056712 A/G cg05729581 chr11:3078854 CARS -0.38 -5.08 -0.3 7.26e-7 Longevity; CESC cis rs3105593 0.575 rs3098174 chr15:50778853 C/T cg08437265 chr15:50716283 USP8 0.49 6.41 0.37 6.65e-10 QT interval; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg04025307 chr7:1156635 C7orf50 0.5 8.5 0.46 1.36e-15 Longevity;Endometriosis; CESC cis rs7680126 0.596 rs10020887 chr4:10140751 C/G cg11266682 chr4:10021025 SLC2A9 -0.46 -5.95 -0.34 8.27e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs4474465 0.688 rs4275650 chr11:78284822 T/A cg27205649 chr11:78285834 NARS2 0.47 6.17 0.35 2.6e-9 Alzheimer's disease (survival time); CESC cis rs4812048 0.689 rs151357 chr20:57609055 A/G cg14073986 chr20:57617431 SLMO2 0.54 5.18 0.3 4.3e-7 Mean platelet volume; CESC cis rs4594175 1.000 rs4594175 chr14:51606541 C/A cg23942311 chr14:51606299 NA 0.39 5.96 0.34 8.22e-9 Cancer; CESC cis rs977987 0.931 rs8057084 chr16:75492706 G/T cg03315344 chr16:75512273 CHST6 -0.52 -7.49 -0.42 1.03e-12 Dupuytren's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06149389 chr14:77499875 NA 0.48 6.04 0.35 5.08e-9 Gut microbiota (bacterial taxa); CESC cis rs7659604 0.540 rs10004284 chr4:122699222 A/T cg19671926 chr4:122722719 EXOSC9 0.66 9.02 0.48 3.96e-17 Type 2 diabetes; CESC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg24531977 chr5:56204891 C5orf35 1.0 13.11 0.63 1.35e-30 Initial pursuit acceleration; CESC cis rs916888 0.779 rs430685 chr17:44859148 T/C cg14517863 chr17:44321492 NA -0.4 -5.17 -0.3 4.56e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg23463467 chr20:60627584 TAF4 0.35 5.06 0.3 7.99e-7 Body mass index; CESC cis rs727563 0.636 rs2413653 chr22:42106996 T/C cg06634786 chr22:41940651 POLR3H 0.67 6.72 0.38 1.12e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs4604732 0.642 rs10925047 chr1:247640143 A/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.35 5.11 0.3 6.11e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg06634786 chr22:41940651 POLR3H 0.7 7.03 0.4 1.8e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.59 0.47 7.62e-16 Colonoscopy-negative controls vs population controls; CESC cis rs367943 0.799 rs10478135 chr5:112976905 C/A cg12552261 chr5:112820674 MCC 0.54 6.14 0.35 2.99e-9 Type 2 diabetes; CESC cis rs1448094 0.717 rs7137122 chr12:86290702 T/C cg02569458 chr12:86230093 RASSF9 0.38 5.49 0.32 9.45e-8 Major depressive disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06583696 chr2:26101536 ASXL2 -0.49 -7.15 -0.4 8.32e-12 Gambling; CESC cis rs72634258 0.554 rs12723500 chr1:7857374 G/C cg26816564 chr1:7831052 VAMP3 0.68 6.12 0.35 3.32e-9 Inflammatory bowel disease; CESC cis rs208515 0.556 rs12214562 chr6:66681011 T/A cg07460842 chr6:66804631 NA 0.86 10.87 0.56 5.19e-23 Exhaled nitric oxide levels; CESC cis rs2276314 0.857 rs6507157 chr18:33631703 A/C cg05985134 chr18:33552581 C18orf21 0.62 7.16 0.4 8.06e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs2228479 0.850 rs62052711 chr16:89855100 C/A cg06558623 chr16:89946397 TCF25 1.18 9.44 0.5 1.97e-18 Skin colour saturation; CESC cis rs7953249 0.564 rs1183910 chr12:121420807 G/A cg25281562 chr12:121454272 C12orf43 0.55 6.58 0.37 2.53e-10 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg23463467 chr20:60627584 TAF4 -0.35 -5.1 -0.3 6.56e-7 Body mass index; CESC cis rs748404 0.578 rs576557 chr15:43597737 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.63 8.4 0.46 2.68e-15 Lung cancer; CESC cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg17376030 chr22:41985996 PMM1 0.74 8.34 0.46 4.24e-15 Vitiligo; CESC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg22800045 chr5:56110881 MAP3K1 0.83 9.98 0.52 3.92e-20 Initial pursuit acceleration; CESC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.87 9.04 0.49 3.44e-17 Platelet count; CESC cis rs2243480 1.000 rs316317 chr7:65613637 G/T cg18252515 chr7:66147081 NA -1.41 -14.48 -0.66 2.11e-35 Diabetic kidney disease; CESC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg18761221 chr20:60518478 NA -0.53 -7.68 -0.43 3.04e-13 Obesity-related traits; CESC cis rs9926296 0.572 rs2079671 chr16:89884981 T/C cg27121462 chr16:89883253 FANCA 0.62 8.02 0.44 3.5e-14 Vitiligo; CESC cis rs12142240 0.698 rs6703374 chr1:46862332 C/G cg10495392 chr1:46806563 NSUN4 0.56 6.17 0.35 2.61e-9 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25959527 chr3:195163920 ACAP2 0.58 6.21 0.36 2.05e-9 Gut microbiome composition (summer); CESC cis rs3793683 0.965 rs3829131 chr10:134564627 A/G cg26818010 chr10:134567672 INPP5A 0.51 6.3 0.36 1.2e-9 Migraine; CESC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg09455208 chr3:40491958 NA 0.49 8.1 0.45 1.99e-14 Renal cell carcinoma; CESC cis rs7524258 0.835 rs7543228 chr1:7306538 G/C cg07173049 chr1:7289937 CAMTA1 0.36 5.62 0.33 4.83e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 6.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC trans rs208520 0.770 rs2153941 chr6:66885521 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.49 -0.58 4.62e-25 Exhaled nitric oxide output; CESC cis rs881375 0.715 rs10760119 chr9:123646060 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 6.09 0.35 4.05e-9 Rheumatoid arthritis; CESC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg19077165 chr18:44547161 KATNAL2 -0.49 -6.67 -0.38 1.51e-10 Personality dimensions; CESC cis rs35110281 0.626 rs162389 chr21:44936227 T/C cg21573476 chr21:45109991 RRP1B -0.35 -5.15 -0.3 5.01e-7 Mean corpuscular volume; CESC cis rs2204008 0.811 rs2139752 chr12:38370398 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.26 0.36 1.57e-9 Bladder cancer; CESC cis rs67460515 0.892 rs35100811 chr3:161084046 A/C cg03342759 chr3:160939853 NMD3 -0.55 -7.74 -0.43 2.15e-13 Parkinson's disease; CESC cis rs763014 0.966 rs4144003 chr16:645968 C/T cg09263875 chr16:632152 PIGQ 0.68 11.71 0.58 8.63e-26 Height; CESC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg08736216 chr1:53307985 ZYG11A -0.42 -7.0 -0.4 2.05e-11 Monocyte count; CESC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg10691866 chr7:65817282 TPST1 0.32 5.36 0.31 1.79e-7 Aortic root size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21810621 chr11:1331345 LOC255512;TOLLIP -0.5 -6.49 -0.37 4.22e-10 Ulcerative colitis; CESC trans rs7938889 0.517 rs505689 chr11:95930072 A/G cg20372048 chr12:82752172 CCDC59;C12orf26 0.45 5.99 0.35 6.71e-9 Methadone dose in opioid dependence; CESC cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.16 0.3 4.84e-7 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16902244 chr1:24117464 LYPLA2 -0.54 -6.47 -0.37 4.78e-10 Gut microbiome composition (summer); CESC trans rs1945213 0.694 rs1384099 chr11:55866040 A/C cg03929089 chr4:120376271 NA 0.73 6.92 0.39 3.43e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs9640161 0.830 rs17173681 chr7:150059414 A/G cg10018233 chr7:150070692 REPIN1 -0.37 -5.78 -0.33 2.14e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg13206674 chr6:150067644 NUP43 0.39 5.34 0.31 2.02e-7 Lung cancer; CESC cis rs228769 0.673 rs375677 chr17:42108974 A/C cg19774624 chr17:42201019 HDAC5 0.54 6.12 0.35 3.39e-9 Bone mineral density (hip);Bone mineral density (spine); CESC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg13395646 chr4:1353034 KIAA1530 -0.49 -6.32 -0.36 1.08e-9 Obesity-related traits; CESC cis rs4730250 0.707 rs3729877 chr7:106787065 T/G cg02696742 chr7:106810147 HBP1 0.56 5.3 0.31 2.47e-7 Osteoarthritis; CESC cis rs9611565 0.506 rs4822020 chr22:41700203 C/T cg06481639 chr22:41940642 POLR3H -0.52 -5.74 -0.33 2.57e-8 Vitiligo; CESC cis rs3733585 0.673 rs4697914 chr4:9952266 G/A cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs738322 0.967 rs6001038 chr22:38570585 A/G cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC cis rs362272 0.545 rs3135146 chr4:3307638 C/G cg08886695 chr4:3369023 RGS12 0.41 5.58 0.32 6e-8 Serum sulfate level; CESC cis rs6580649 0.941 rs6580651 chr12:48429933 A/T cg05342945 chr12:48394962 COL2A1 0.51 5.87 0.34 1.3e-8 Lung cancer; CESC cis rs6570726 0.935 rs367612 chr6:145828987 A/G cg23711669 chr6:146136114 FBXO30 0.76 11.31 0.57 1.84e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs11690935 0.851 rs7573003 chr2:172741415 T/A cg13550731 chr2:172543902 DYNC1I2 -0.84 -12.82 -0.62 1.36e-29 Schizophrenia; CESC cis rs11514810 1.000 rs7812242 chr7:1431747 C/T cg24899294 chr7:1481343 MICALL2 -0.65 -5.36 -0.31 1.79e-7 Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder; CESC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 -0.42 -5.8 -0.34 1.89e-8 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg11494091 chr17:61959527 GH2 0.73 12.56 0.61 1.04e-28 Prudent dietary pattern; CESC cis rs67478160 0.634 rs2295140 chr14:104216293 C/T cg01849466 chr14:104193079 ZFYVE21 -0.54 -7.89 -0.44 7.99e-14 Schizophrenia; CESC cis rs1059312 0.932 rs11059916 chr12:129287609 C/A cg09035930 chr12:129282057 SLC15A4 0.78 10.94 0.56 3.13e-23 Systemic lupus erythematosus; CESC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg27121462 chr16:89883253 FANCA 0.76 11.18 0.57 5.09e-24 Vitiligo; CESC cis rs7296418 0.961 rs1790106 chr12:123591596 G/T cg05973401 chr12:123451056 ABCB9 0.57 7.51 0.42 9.17e-13 Platelet count; CESC cis rs2732480 0.538 rs2468943 chr12:48747249 G/T cg24011408 chr12:48396354 COL2A1 -0.37 -5.08 -0.3 6.97e-7 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg17971929 chr21:40555470 PSMG1 1.03 15.23 0.68 4.85e-38 Cognitive function; CESC cis rs2463822 0.583 rs72917379 chr11:62026112 T/C cg06239285 chr11:62104954 ASRGL1 -1.05 -7.91 -0.44 7.04e-14 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs362272 0.524 rs881816 chr4:3365366 A/G cg08886695 chr4:3369023 RGS12 -0.43 -5.86 -0.34 1.35e-8 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10985993 chr2:166810260 TTC21B 0.6 7.14 0.4 9.14e-12 Gut microbiome composition (summer); CESC cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg23711669 chr6:146136114 FBXO30 0.95 12.72 0.62 2.95e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs7086627 0.515 rs10887900 chr10:82210265 A/G cg00277334 chr10:82204260 NA -0.89 -14.86 -0.67 9.67e-37 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23497857 chr14:24685372 MDP1 -0.65 -8.14 -0.45 1.53e-14 Gut microbiome composition (summer); CESC cis rs1801251 1.000 rs283474 chr2:233654627 A/G cg08000102 chr2:233561755 GIGYF2 0.68 9.74 0.51 2.4e-19 Coronary artery disease; CESC cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg25019033 chr10:957182 NA -0.59 -6.23 -0.36 1.86e-9 Eosinophil percentage of granulocytes; CESC cis rs116095464 0.558 rs9312979 chr5:222057 A/C cg22496380 chr5:211416 CCDC127 -0.96 -10.08 -0.53 1.95e-20 Breast cancer; CESC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg04267008 chr7:1944627 MAD1L1 -0.59 -7.26 -0.41 4.18e-12 Bipolar disorder and schizophrenia; CESC cis rs7267979 0.866 rs437635 chr20:25456888 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.78 0.67 1.87e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs7829975 0.535 rs17683510 chr8:8500724 A/G cg06636001 chr8:8085503 FLJ10661 0.4 5.2 0.3 3.98e-7 Mood instability; CESC cis rs397969 0.596 rs12453720 chr17:19895202 A/G cg12073167 chr17:19770448 ULK2 0.46 5.39 0.31 1.55e-7 Platelet count; CESC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg24549020 chr5:56110836 MAP3K1 0.57 6.18 0.35 2.45e-9 Initial pursuit acceleration; CESC cis rs597539 0.654 rs7107137 chr11:68623712 A/G cg01988459 chr11:68622903 NA -0.41 -5.3 -0.31 2.4e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg04234412 chr22:24373322 LOC391322 -0.62 -9.19 -0.49 1.18e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs17428041 0.521 rs13255951 chr8:21722998 T/C cg17168535 chr8:21777572 XPO7 -0.44 -5.83 -0.34 1.61e-8 Neuropathic pain in type 2 diabetes; CESC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs694739 0.628 rs617051 chr11:64133638 C/A cg23796481 chr11:64053134 BAD;GPR137 0.56 6.87 0.39 4.63e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs116095464 0.558 rs6866776 chr5:264495 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.49 0.32 9.44e-8 Breast cancer; CESC cis rs56104184 0.775 rs56317021 chr19:49395960 C/T cg15549821 chr19:49342101 PLEKHA4 -0.58 -5.8 -0.34 1.9e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7312774 0.618 rs61061573 chr12:107372758 T/C cg16260113 chr12:107380972 MTERFD3 0.95 7.37 0.41 2.16e-12 Severe influenza A (H1N1) infection; CESC cis rs3741151 1.000 rs3741151 chr11:73020846 G/T cg17517138 chr11:73019481 ARHGEF17 1.16 8.06 0.44 2.63e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.2 -0.36 2.21e-9 Parkinson's disease; CESC cis rs12801636 0.739 rs12790427 chr11:65384727 C/T cg01685242 chr11:65405760 SIPA1 0.46 5.07 0.3 7.63e-7 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; CESC cis rs3749237 0.595 rs2878298 chr3:49406080 T/C cg07636037 chr3:49044803 WDR6 0.62 8.99 0.48 4.79e-17 Resting heart rate; CESC cis rs2282802 0.617 rs10477348 chr5:139666906 A/T cg26211634 chr5:139558579 C5orf32 0.5 7.08 0.4 1.28e-11 Intelligence (multi-trait analysis); CESC cis rs1728785 1.000 rs7195979 chr16:68586801 G/A cg02972257 chr16:68554789 NA -0.66 -7.38 -0.41 2.03e-12 Ulcerative colitis; CESC cis rs4253772 0.637 rs8135997 chr22:46651366 G/A cg24881330 chr22:46731750 TRMU 0.89 10.09 0.53 1.86e-20 LDL cholesterol;Cholesterol, total; CESC cis rs709400 0.663 rs17617941 chr14:103953032 T/C cg12935359 chr14:103987150 CKB -0.57 -8.39 -0.46 2.88e-15 Body mass index; CESC cis rs6163 0.588 rs12763284 chr10:104508202 C/T cg04362960 chr10:104952993 NT5C2 -0.37 -5.14 -0.3 5.37e-7 Waist circumference;Hip circumference; CESC cis rs6426558 0.537 rs689094 chr1:227308909 G/A cg10327440 chr1:227177885 CDC42BPA 0.46 5.77 0.33 2.19e-8 Neutrophil percentage of white cells; CESC cis rs748404 0.697 rs475227 chr15:43546446 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.61 8.07 0.44 2.39e-14 Lung cancer; CESC cis rs12618769 0.652 rs13402379 chr2:99209314 G/A cg10123293 chr2:99228465 UNC50 0.39 5.1 0.3 6.61e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09847284 chr11:45907071 MAPK8IP1 0.67 7.28 0.41 3.77e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17282910 chr5:89825494 LYSMD3 -0.54 -6.04 -0.35 5.28e-9 Gut microbiome composition (summer); CESC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg25767906 chr1:53392781 SCP2 -0.52 -7.16 -0.4 7.76e-12 Monocyte count; CESC cis rs7903847 0.642 rs7896100 chr10:99156994 C/T cg20016023 chr10:99160130 RRP12 -0.3 -5.19 -0.3 4.18e-7 Granulocyte percentage of myeloid white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17358899 chr7:148580458 EZH2 -0.48 -6.77 -0.38 8.09e-11 Gambling; CESC cis rs11122272 0.701 rs2486725 chr1:231540288 G/C cg06096015 chr1:231504339 EGLN1 0.42 6.05 0.35 4.97e-9 Hemoglobin concentration; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg06508976 chr9:131940586 IER5L 0.46 6.18 0.35 2.43e-9 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19731367 chr10:95256484 CEP55 -0.49 -7.18 -0.4 6.88e-12 Fibrinogen levels; CESC trans rs11098499 0.863 rs1480939 chr4:120456927 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.47e-19 Corneal astigmatism; CESC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg03609598 chr5:56110824 MAP3K1 -0.51 -5.5 -0.32 9.11e-8 Initial pursuit acceleration; CESC cis rs8044868 0.606 rs7189591 chr16:72099011 G/T cg16558253 chr16:72132732 DHX38 -0.41 -6.44 -0.37 5.61e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs4975709 0.838 rs4975753 chr5:1880865 T/C cg17650747 chr5:1873721 NA 0.38 5.19 0.3 4.24e-7 Cardiovascular disease risk factors; CESC cis rs372883 0.506 rs2832300 chr21:30749315 A/G cg24692254 chr21:30365293 RNF160 0.47 5.89 0.34 1.14e-8 Pancreatic cancer; CESC cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg12193833 chr17:30244370 NA -0.58 -6.22 -0.36 1.95e-9 Hip circumference adjusted for BMI; CESC trans rs61931739 0.534 rs10844840 chr12:34364517 C/T cg26384229 chr12:38710491 ALG10B 0.68 10.06 0.53 2.22e-20 Morning vs. evening chronotype; CESC cis rs1670533 1.000 rs652063 chr4:1084137 T/C cg04106633 chr4:1044584 NA 0.4 5.08 0.3 6.98e-7 Recombination rate (females); CESC trans rs116095464 0.558 rs9312956 chr5:201812 T/C cg00938859 chr5:1591904 SDHAP3 0.62 6.01 0.35 6.17e-9 Breast cancer; CESC cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg26597838 chr10:835615 NA 0.91 9.95 0.52 5.15e-20 Eosinophil percentage of granulocytes; CESC cis rs8072100 0.764 rs4794371 chr17:45627693 G/C cg08085267 chr17:45401833 C17orf57 0.4 5.22 0.31 3.64e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7927771 0.524 rs9633830 chr11:47849470 T/G cg18512352 chr11:47633146 NA 0.35 5.33 0.31 2.05e-7 Subjective well-being; CESC cis rs116095464 0.558 rs6866632 chr5:264429 C/G cg22857025 chr5:266934 NA -1.29 -16.06 -0.7 5.35e-41 Breast cancer; CESC cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg05585544 chr11:47624801 NA -0.49 -7.12 -0.4 1.03e-11 Subjective well-being; CESC cis rs55894533 0.597 rs2645408 chr8:11746358 A/G cg21281001 chr8:11725306 CTSB 0.48 5.82 0.34 1.69e-8 Leprosy; CESC trans rs2282526 0.615 rs463738 chr21:44921166 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.49 -6.18 -0.35 2.35e-9 Mean corpuscular hemoglobin; CESC cis rs1371867 0.839 rs1788186 chr8:101335686 T/C cg11906718 chr8:101322791 RNF19A 0.46 5.91 0.34 1.03e-8 Atrioventricular conduction; CESC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.66 0.64 1.57e-32 Prudent dietary pattern; CESC cis rs3818285 0.632 rs536343 chr10:111632879 T/C cg00817464 chr10:111662876 XPNPEP1 0.44 6.7 0.38 1.21e-10 Superior crus of antihelix expression; CESC cis rs7937682 0.632 rs4935811 chr11:111679262 C/T cg09085632 chr11:111637200 PPP2R1B 0.85 10.45 0.54 1.21e-21 Primary sclerosing cholangitis; CESC cis rs7089973 0.872 rs34064819 chr10:116621154 C/A cg23260525 chr10:116636907 FAM160B1 0.38 6.35 0.36 9.27e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9309473 1.000 rs11893881 chr2:73824373 T/A cg20560298 chr2:73613845 ALMS1 -0.54 -7.01 -0.4 2e-11 Metabolite levels; CESC cis rs6424115 1.000 rs2256179 chr1:24132305 A/G cg15997130 chr1:24165203 NA -0.42 -5.8 -0.34 1.89e-8 Immature fraction of reticulocytes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19318450 chr21:34852305 TMEM50B -0.48 -6.04 -0.35 5.1e-9 Ulcerative colitis; CESC cis rs72781680 1.000 rs72798408 chr2:24181845 G/C cg08917208 chr2:24149416 ATAD2B 1.11 10.02 0.52 3.07e-20 Lymphocyte counts; CESC cis rs12900413 0.687 rs28435184 chr15:90306732 T/C cg24249390 chr15:90295951 MESP1 -0.42 -5.69 -0.33 3.34e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs7772486 0.902 rs1125462 chr6:146417832 A/G cg23711669 chr6:146136114 FBXO30 0.73 10.72 0.55 1.59e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg09323728 chr8:95962352 TP53INP1 -0.41 -8.98 -0.48 5.27e-17 Type 2 diabetes; CESC cis rs9611519 0.780 rs2235852 chr22:41661154 G/T cg03806693 chr22:41940476 POLR3H -0.55 -6.43 -0.37 5.78e-10 Neuroticism; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14837817 chr8:144692253 PYCRL -0.46 -6.05 -0.35 4.9e-9 Asthma; CESC cis rs9611565 0.512 rs5758439 chr22:42131762 C/T cg03806693 chr22:41940476 POLR3H 1.16 13.59 0.64 2.85e-32 Vitiligo; CESC cis rs2072732 0.821 rs60287244 chr1:2943668 A/G cg15211996 chr1:2936768 ACTRT2 0.35 5.74 0.33 2.65e-8 Plateletcrit; CESC cis rs9399135 0.967 rs4896121 chr6:135293645 T/C cg22676075 chr6:135203613 NA 0.52 7.12 0.4 1e-11 Red blood cell count; CESC cis rs7833986 0.501 rs72653986 chr8:57035048 T/C cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.41 0.32 1.42e-7 Height; CESC cis rs10129255 0.500 rs6576231 chr14:107191930 T/C cg07958169 chr14:107095056 NA -0.54 -8.32 -0.46 4.65e-15 Kawasaki disease; CESC cis rs3762637 1.000 rs12638866 chr3:122194382 T/C cg24169773 chr3:122142474 KPNA1 -0.54 -6.33 -0.36 1.04e-9 LDL cholesterol levels; CESC cis rs67478160 0.595 rs12879501 chr14:104272634 G/T cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.07 -0.4 1.39e-11 Schizophrenia; CESC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg27170947 chr2:26402098 FAM59B -0.89 -10.77 -0.55 1.17e-22 Gut microbiome composition (summer); CESC cis rs2070488 0.965 rs7372849 chr3:38524328 G/C cg24069376 chr3:38537580 EXOG 0.47 8.57 0.47 8.51e-16 Electrocardiographic conduction measures; CESC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg18337363 chr3:52569053 NT5DC2 0.28 5.2 0.3 3.94e-7 Bipolar disorder; CESC cis rs7872515 0.887 rs7029539 chr9:94864322 A/G cg01248375 chr9:94877805 SPTLC1 0.56 6.1 0.35 3.81e-9 Bipolar disorder and schizophrenia; CESC trans rs7618501 1.000 rs60205400 chr3:49800272 C/T cg21659725 chr3:3221576 CRBN 0.83 13.56 0.64 3.67e-32 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01945625 chr16:1437845 NA -0.54 -6.48 -0.37 4.33e-10 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs56378576 chr17:29010120 C/T cg14008862 chr17:28927542 LRRC37B2 0.73 5.82 0.34 1.67e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.82e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.5 0.42 9.93e-13 Prudent dietary pattern; CESC cis rs561341 0.709 rs8068049 chr17:30183857 T/C cg19193384 chr17:30244184 NA 0.57 5.31 0.31 2.37e-7 Hip circumference adjusted for BMI; CESC trans rs1814175 0.781 rs12286395 chr11:49954062 C/G cg03929089 chr4:120376271 NA -0.93 -15.75 -0.7 6.66e-40 Height; CESC cis rs17253792 0.822 rs76164147 chr14:56140369 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs1642645 0.872 rs7550500 chr1:42505522 T/C cg16685388 chr1:42384056 HIVEP3 0.4 5.87 0.34 1.31e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs4654899 1.000 rs7543126 chr1:21406088 T/G cg05370193 chr1:21551575 ECE1 0.37 5.56 0.32 6.48e-8 Superior frontal gyrus grey matter volume; CESC cis rs2760061 0.603 rs697762 chr1:228192410 G/A cg02753203 chr1:228287806 NA 0.72 11.27 0.57 2.57e-24 Diastolic blood pressure; CESC cis rs2116941 1.000 rs7250265 chr19:10339818 G/C cg01850179 chr19:10340795 S1PR2 -0.59 -7.61 -0.42 4.9e-13 Pulse pressure; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg09311052 chr1:154531418 UBE2Q1 0.49 6.62 0.38 2e-10 Obesity-related traits; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22546437 chr19:47987707 KPTN -0.49 -6.09 -0.35 3.89e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6028335 0.674 rs6028234 chr20:37607869 A/C cg16355469 chr20:37678765 NA 0.51 5.09 0.3 6.82e-7 Alcohol and nicotine co-dependence; CESC cis rs7432375 0.609 rs835637 chr3:136673157 A/T cg15507776 chr3:136538369 TMEM22 0.56 7.17 0.4 7.5e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13852536 chr9:32567045 NDUFB6 0.54 7.67 0.43 3.22e-13 Fibrinogen levels; CESC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.35 -0.31 1.91e-7 Lung cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12897370 chr6:155055079 RBM16 -0.49 -6.15 -0.35 2.8e-9 Ulcerative colitis; CESC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg27170947 chr2:26402098 FAM59B 0.56 6.87 0.39 4.58e-11 Gut microbiome composition (summer); CESC trans rs8073060 0.586 rs225300 chr17:33922428 C/T cg19694781 chr19:47549865 TMEM160 -0.72 -6.95 -0.39 2.85e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs36051895 0.623 rs2208685 chr9:5251758 T/C cg02405213 chr9:5042618 JAK2 -0.53 -6.27 -0.36 1.43e-9 Pediatric autoimmune diseases; CESC cis rs7254114 0.645 rs57681847 chr19:11300648 G/T cg02815516 chr19:11306319 KANK2 -0.38 -5.85 -0.34 1.44e-8 Immature fraction of reticulocytes; CESC cis rs7296418 0.885 rs1790104 chr12:123709409 C/T cg05973401 chr12:123451056 ABCB9 0.51 6.63 0.38 1.88e-10 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13499067 chr11:10879629 ZBED5 0.63 7.11 0.4 1.11e-11 Gut microbiome composition (summer); CESC trans rs61931739 0.500 rs12146843 chr12:34451738 T/G cg26384229 chr12:38710491 ALG10B 0.54 7.5 0.42 9.79e-13 Morning vs. evening chronotype; CESC trans rs7615952 0.800 rs13086460 chr3:125646417 C/T cg07211511 chr3:129823064 LOC729375 -1.14 -15.22 -0.68 5.24e-38 Blood pressure (smoking interaction); CESC cis rs9660992 0.573 rs4400674 chr1:205218425 A/C cg00857998 chr1:205179979 DSTYK -0.56 -6.84 -0.39 5.5e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs10754283 0.967 rs10737708 chr1:90119804 A/G cg21401794 chr1:90099060 LRRC8C 0.66 8.77 0.47 2.18e-16 Amyotrophic lateral sclerosis (sporadic); CESC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.53 -6.48 -0.37 4.48e-10 Prudent dietary pattern; CESC cis rs2204008 0.540 rs3908193 chr12:38410907 G/T cg26384229 chr12:38710491 ALG10B -0.45 -6.09 -0.35 4.05e-9 Bladder cancer; CESC cis rs6964587 1.000 rs9784993 chr7:91672403 G/A cg17063962 chr7:91808500 NA 0.59 8.15 0.45 1.48e-14 Breast cancer; CESC cis rs6542838 0.611 rs1976766 chr2:99522754 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.23 -0.31 3.53e-7 Fear of minor pain; CESC cis rs9902453 0.967 rs12450956 chr17:28529025 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 7.06 0.4 1.43e-11 Coffee consumption (cups per day); CESC cis rs72781680 0.898 rs12620558 chr2:23936022 G/A cg08917208 chr2:24149416 ATAD2B 1.1 10.15 0.53 1.18e-20 Lymphocyte counts; CESC cis rs2281558 0.833 rs12480853 chr20:25522959 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.55 7.61 0.42 4.83e-13 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg24562669 chr7:97807699 LMTK2 0.51 7.53 0.42 7.86e-13 Prostate cancer (SNP x SNP interaction); CESC trans rs28735056 0.903 rs56185453 chr18:77638297 A/G cg05926928 chr17:57297772 GDPD1 -0.62 -7.79 -0.43 1.49e-13 Schizophrenia; CESC cis rs12142240 0.698 rs12385695 chr1:46819021 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs9905704 0.624 rs6503891 chr17:57065924 A/C cg12560992 chr17:57184187 TRIM37 0.66 8.09 0.44 2.21e-14 Testicular germ cell tumor; CESC cis rs1609391 0.561 rs9817967 chr3:136629490 G/A cg15507776 chr3:136538369 TMEM22 0.81 11.89 0.59 2.08e-26 Neuroticism; CESC cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg13628971 chr7:2884303 GNA12 0.39 5.07 0.3 7.49e-7 Height; CESC cis rs3820068 0.603 rs7537618 chr1:15977682 G/A cg17385448 chr1:15911702 AGMAT 0.43 7.04 0.4 1.66e-11 Systolic blood pressure; CESC cis rs7584330 0.740 rs11891348 chr2:238440449 T/G cg14458575 chr2:238380390 NA 0.71 10.15 0.53 1.19e-20 Prostate cancer; CESC cis rs9660992 0.674 rs1151784 chr1:205232447 C/T cg00857998 chr1:205179979 DSTYK 0.47 5.35 0.31 1.87e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs644799 0.965 rs11021310 chr11:95502106 A/C cg25622487 chr11:95524042 FAM76B;CEP57 0.72 9.53 0.51 1.05e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs61774743 0.557 rs4660192 chr1:41842350 C/T cg08462924 chr1:41848221 NA 0.4 5.43 0.32 1.27e-7 Intelligence (multi-trait analysis); CESC cis rs3008870 1.000 rs12740884 chr1:67459855 C/A cg02640540 chr1:67518911 SLC35D1 -0.51 -5.58 -0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.79 8.31 0.45 5.17e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11048434 0.761 rs12827988 chr12:9130287 A/G cg23795048 chr12:9217529 LOC144571 0.34 5.05 0.3 8.31e-7 Sjögren's syndrome; CESC cis rs228437 1.000 rs985121 chr6:134930893 C/T cg24504307 chr6:134963096 NA 0.55 5.93 0.34 9.31e-9 Melanoma; CESC cis rs4253772 0.591 rs11704586 chr22:46685274 T/C cg24881330 chr22:46731750 TRMU 0.75 5.43 0.32 1.25e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg21782813 chr7:2030301 MAD1L1 0.51 7.2 0.4 6.27e-12 Bipolar disorder and schizophrenia; CESC cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg13298116 chr11:62369859 EML3;MTA2 0.66 9.93 0.52 5.98e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17146150 chr15:56657437 TEX9 0.48 6.05 0.35 5.03e-9 Gut microbiota (bacterial taxa); CESC cis rs9911578 1.000 rs8071280 chr17:57010225 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.13 0.3 5.67e-7 Intelligence (multi-trait analysis); CESC trans rs11098499 0.691 rs10028773 chr4:120265259 C/G cg25214090 chr10:38739885 LOC399744 -0.58 -7.81 -0.43 1.31e-13 Corneal astigmatism; CESC cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg07636037 chr3:49044803 WDR6 1.05 18.48 0.75 1.44e-49 Parkinson's disease; CESC cis rs11997175 0.653 rs7817167 chr8:33633088 A/C ch.8.33884649F chr8:33765107 NA 0.55 6.86 0.39 4.88e-11 Body mass index; CESC cis rs4808199 0.948 rs11085261 chr19:19462606 G/A cg03709012 chr19:19516395 GATAD2A 1.08 12.28 0.6 9.85e-28 Nonalcoholic fatty liver disease; CESC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg11247378 chr22:39784982 NA 0.63 9.48 0.5 1.53e-18 Intelligence (multi-trait analysis); CESC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg08109568 chr15:31115862 NA -0.68 -9.22 -0.49 9.92e-18 Huntington's disease progression; CESC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg00166722 chr3:10149974 C3orf24 0.45 5.63 0.33 4.62e-8 Alzheimer's disease; CESC cis rs1707322 1.000 rs3922886 chr1:46473902 A/T cg03146154 chr1:46216737 IPP 0.73 9.95 0.52 5.12e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17645130 chr1:115053969 TRIM33 0.57 6.46 0.37 5.03e-10 Gut microbiome composition (summer); CESC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg26338869 chr17:61819248 STRADA 0.7 9.25 0.49 7.94e-18 Prudent dietary pattern; CESC cis rs7520050 0.933 rs12045165 chr1:46256022 C/A cg24296786 chr1:45957014 TESK2 0.44 5.64 0.33 4.37e-8 Red blood cell count;Reticulocyte count; CESC cis rs561341 0.609 rs2051810 chr17:30195841 C/T cg13647721 chr17:30228624 UTP6 -0.74 -8.55 -0.46 9.94e-16 Hip circumference adjusted for BMI; CESC trans rs35110281 0.744 rs230646 chr21:44918788 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 7.1 0.4 1.12e-11 Mean corpuscular volume; CESC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg23758822 chr17:41437982 NA 1.03 16.08 0.7 4.57e-41 Menopause (age at onset); CESC cis rs10905065 1.000 rs2380199 chr10:5803689 C/T cg11519256 chr10:5708881 ASB13 0.38 5.08 0.3 7.12e-7 Menopause (age at onset); CESC cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg03676636 chr4:99064102 C4orf37 0.33 5.1 0.3 6.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8005677 1.000 rs8014936 chr14:23375145 A/G cg25600027 chr14:23388339 RBM23 -0.41 -5.04 -0.3 8.45e-7 Cognitive ability (multi-trait analysis); CESC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg06808227 chr14:105710500 BRF1 0.43 5.43 0.32 1.26e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7084402 0.967 rs11817440 chr10:60272369 T/C cg07615347 chr10:60278583 BICC1 -0.57 -8.87 -0.48 1.12e-16 Refractive error; CESC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg05863683 chr7:1912471 MAD1L1 0.38 5.63 0.33 4.63e-8 Schizophrenia; CESC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg12311346 chr5:56204834 C5orf35 -0.6 -7.95 -0.44 5.23e-14 Coronary artery disease; CESC cis rs7208859 0.573 rs73267872 chr17:29067207 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.14e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3008870 0.755 rs2815363 chr1:67497221 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.6 -7.93 -0.44 6.25e-14 Lymphocyte percentage of white cells; CESC cis rs7208859 0.573 rs11654035 chr17:29136426 T/C cg14008862 chr17:28927542 LRRC37B2 0.69 5.37 0.31 1.7e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs76419734 0.510 rs2544402 chr4:106687733 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.61 -6.29 -0.36 1.31e-9 Post bronchodilator FEV1; CESC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg19257562 chr1:2043853 PRKCZ 0.4 6.55 0.37 2.99e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13652281 chr17:80393504 HEXDC -0.5 -6.15 -0.35 2.82e-9 Gut microbiome composition (summer); CESC cis rs11098499 0.722 rs17595727 chr4:120262074 C/T cg09307838 chr4:120376055 NA -0.75 -9.99 -0.52 3.85e-20 Corneal astigmatism; CESC cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg22509189 chr2:225307070 NA -0.41 -5.29 -0.31 2.51e-7 IgE levels in asthmatics (D.p. specific); CESC cis rs9300255 0.602 rs1106241 chr12:123627016 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.58 0.47 8.2e-16 Neutrophil percentage of white cells; CESC cis rs113835537 0.877 rs77239910 chr11:66329639 G/A cg22134325 chr11:66188745 NPAS4 0.52 6.0 0.35 6.58e-9 Airway imaging phenotypes; CESC cis rs25645 0.830 rs3935281 chr17:38188419 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.61 8.68 0.47 4.23e-16 Myeloid white cell count; CESC cis rs9815354 0.716 rs73087368 chr3:41930379 A/G cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs5769765 0.671 rs138832 chr22:50178082 A/G cg26441486 chr22:50317300 CRELD2 0.4 5.2 0.3 3.96e-7 Schizophrenia; CESC cis rs2425143 1.000 rs57963833 chr20:34344225 T/A cg23207816 chr20:34252616 CPNE1;RBM12 0.67 5.92 0.34 1.01e-8 Blood protein levels; CESC cis rs3820928 1.000 rs6752707 chr2:227766822 C/G cg05526886 chr2:227700861 RHBDD1 -0.43 -5.63 -0.33 4.53e-8 Pulmonary function; CESC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg07507251 chr3:52567010 NT5DC2 0.4 7.11 0.4 1.1e-11 Bipolar disorder; CESC cis rs9303401 0.614 rs34683543 chr17:56520036 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.95 11.71 0.58 8.62e-26 Cognitive test performance; CESC cis rs6540556 0.678 rs11119330 chr1:209889659 A/G cg05527609 chr1:210001259 C1orf107 -0.68 -7.38 -0.41 2.11e-12 Red blood cell count; CESC cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.9 0.62 7.31e-30 Colonoscopy-negative controls vs population controls; CESC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg13628971 chr7:2884303 GNA12 0.65 8.39 0.46 2.85e-15 Height; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg22377913 chr1:26758610 DHDDS -0.49 -6.05 -0.35 5e-9 Recombination measurement; CESC cis rs6456156 0.586 rs9457266 chr6:167482555 T/C cg23791538 chr6:167370224 RNASET2 -0.51 -6.44 -0.37 5.67e-10 Primary biliary cholangitis; CESC cis rs4253772 0.938 rs14842 chr22:46639457 A/T cg18190219 chr22:46762943 CELSR1 -0.61 -5.82 -0.34 1.66e-8 LDL cholesterol;Cholesterol, total; CESC cis rs17253792 0.822 rs28681420 chr14:56088403 G/T cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07195508 chr1:67390935 MIER1;WDR78 0.59 6.27 0.36 1.46e-9 Gut microbiome composition (summer); CESC cis rs6088580 0.634 rs6088488 chr20:32992631 T/C cg24642439 chr20:33292090 TP53INP2 -0.52 -6.9 -0.39 3.82e-11 Glomerular filtration rate (creatinine); CESC cis rs7524258 0.901 rs11120884 chr1:7305361 C/A cg07173049 chr1:7289937 CAMTA1 0.37 5.69 0.33 3.32e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00529053 chr6:158589440 GTF2H5;SERAC1 -0.48 -6.28 -0.36 1.38e-9 Ulcerative colitis; CESC cis rs34779708 0.966 rs11592567 chr10:35409369 C/T cg03585969 chr10:35415529 CREM 0.77 10.1 0.53 1.71e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg04455712 chr21:45112962 RRP1B 0.4 5.93 0.34 9.32e-9 Mean corpuscular volume; CESC cis rs10129255 0.642 rs11624918 chr14:107120688 T/C cg23076370 chr14:107095027 NA -0.54 -7.11 -0.4 1.05e-11 Kawasaki disease; CESC cis rs921968 0.541 rs3731867 chr2:219472734 G/A cg02176678 chr2:219576539 TTLL4 -0.53 -9.13 -0.49 1.85e-17 Mean corpuscular hemoglobin concentration; CESC cis rs9457247 0.565 rs12178491 chr6:167512474 C/T cg23791538 chr6:167370224 RNASET2 -0.54 -7.03 -0.4 1.73e-11 Crohn's disease; CESC cis rs2732480 0.557 rs2732484 chr12:48737245 A/C cg04545296 chr12:48745243 ZNF641 0.44 7.22 0.41 5.44e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg27266027 chr21:40555129 PSMG1 0.47 5.63 0.33 4.62e-8 Cognitive function; CESC cis rs933688 1.000 rs10041402 chr5:90738948 A/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 14.03 0.65 8.31e-34 Smoking behavior; CESC cis rs59918340 0.764 rs2304282 chr8:142229543 A/G cg23750338 chr8:142222470 SLC45A4 0.61 9.16 0.49 1.45e-17 Immature fraction of reticulocytes; CESC cis rs62158211 0.691 rs1964463 chr2:114069021 C/T cg17784749 chr2:114082611 LOC440839 -0.66 -7.45 -0.42 1.36e-12 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CESC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC cis rs7100689 0.622 rs1340379 chr10:82121455 G/A cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC trans rs7839040 0.698 rs10504746 chr8:82928476 C/A cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs921968 0.565 rs1079177 chr2:219605929 G/A cg02176678 chr2:219576539 TTLL4 -0.46 -8.21 -0.45 9.84e-15 Mean corpuscular hemoglobin concentration; CESC trans rs875971 0.964 rs778708 chr7:65856319 T/C cg26939375 chr7:64535504 NA 0.47 6.14 0.35 3.07e-9 Aortic root size; CESC cis rs2806561 0.704 rs6680974 chr1:23376233 A/G cg12483005 chr1:23474871 LUZP1 0.34 5.22 0.31 3.61e-7 Height; CESC cis rs727505 0.721 rs11536526 chr7:124749441 G/A cg23710748 chr7:124431027 NA -0.38 -6.26 -0.36 1.54e-9 Lewy body disease; CESC trans rs2727020 0.521 rs2088526 chr11:49531968 G/A cg15704280 chr7:45808275 SEPT13 0.82 9.96 0.52 4.58e-20 Coronary artery disease; CESC cis rs1059312 1.000 rs3825180 chr12:129279242 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.73 10.1 0.53 1.74e-20 Systemic lupus erythematosus; CESC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.95 0.65 1.55e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs1728785 0.688 rs698729 chr16:68624205 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.72 0.43 2.35e-13 Ulcerative colitis; CESC cis rs6570726 0.935 rs384453 chr6:145815145 G/C cg23711669 chr6:146136114 FBXO30 0.82 12.29 0.6 8.74e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs9902453 0.808 rs76515799 chr17:28169491 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.37 0.46 3.33e-15 Coffee consumption (cups per day); CESC cis rs4237845 0.742 rs6650219 chr12:58289100 T/C cg00677455 chr12:58241039 CTDSP2 0.44 5.78 0.33 2.09e-8 Intelligence (multi-trait analysis); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13819485 chr11:118868642 CCDC84 0.48 6.42 0.37 6.2e-10 Systemic lupus erythematosus; CESC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg27121462 chr16:89883253 FANCA 0.61 8.1 0.45 2.06e-14 Vitiligo; CESC cis rs614226 0.872 rs12307148 chr12:120903179 T/C cg27489772 chr12:121021490 NA -0.5 -5.1 -0.3 6.48e-7 Type 1 diabetes nephropathy; CESC cis rs4654899 1.000 rs6669102 chr1:21355543 A/G cg05370193 chr1:21551575 ECE1 0.4 6.14 0.35 2.95e-9 Superior frontal gyrus grey matter volume; CESC cis rs17253792 0.822 rs80174205 chr14:56058694 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.62 0.33 4.81e-8 Putamen volume; CESC cis rs2235544 0.588 rs664758 chr1:54461263 C/T cg25741118 chr1:54482237 LDLRAD1 0.24 6.0 0.35 6.31e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs911555 0.755 rs4143998 chr14:103955247 T/C cg09975044 chr14:104007538 NA 0.43 5.28 0.31 2.68e-7 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.75 10.62 0.55 3.37e-22 Prudent dietary pattern; CESC cis rs7191439 0.790 rs8060966 chr16:88777329 A/G cg27087555 chr16:88793112 FAM38A -0.92 -7.61 -0.42 4.75e-13 Plateletcrit; CESC cis rs9796 0.621 rs691702 chr15:41474399 C/G cg12386646 chr15:41787261 ITPKA 0.33 5.08 0.3 7.11e-7 Menopause (age at onset); CESC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg10883421 chr6:151773342 RMND1;C6orf211 0.87 15.14 0.68 9.75e-38 Menarche (age at onset); CESC cis rs847577 0.569 rs35101190 chr7:97695888 G/A cg24562669 chr7:97807699 LMTK2 0.78 13.23 0.63 5.22e-31 Breast cancer; CESC trans rs6934970 0.556 rs62414949 chr6:112986802 T/G cg05146922 chr2:10634174 NA -0.37 -6.17 -0.35 2.53e-9 Bipolar disorder (body mass index interaction); CESC cis rs7923609 0.967 rs3956912 chr10:65205881 C/T cg01631684 chr10:65280961 REEP3 -0.43 -5.39 -0.31 1.55e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs9916302 0.706 rs8069074 chr17:37685401 C/T cg00129232 chr17:37814104 STARD3 0.49 5.05 0.3 8.34e-7 Glomerular filtration rate (creatinine); CESC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg10691866 chr7:65817282 TPST1 -0.33 -5.39 -0.31 1.58e-7 Aortic root size; CESC cis rs1976403 0.659 rs10799701 chr1:21820990 A/G cg21906605 chr1:21766650 NBPF3 0.39 5.15 0.3 5.13e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs4727027 0.782 rs10245343 chr7:148796333 T/C cg23583168 chr7:148888333 NA -0.72 -9.39 -0.5 2.92e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3806843 0.735 rs801183 chr5:140091115 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.42 -5.58 -0.32 5.9e-8 Depressive symptoms (multi-trait analysis); CESC cis rs2072510 0.569 rs7970524 chr12:96390152 A/G cg09636302 chr12:96389483 HAL -0.47 -5.87 -0.34 1.3e-8 Metabolite levels (small molecules and protein measures); CESC cis rs3825932 1.000 rs3825932 chr15:79235446 A/G cg25744700 chr15:79237217 CTSH 0.46 6.25 0.36 1.6e-9 Type 1 diabetes; CESC cis rs2180341 1.000 rs2144743 chr6:127633810 A/T cg27446573 chr6:127587934 RNF146 1.09 16.38 0.71 3.79e-42 Breast cancer; CESC cis rs67311347 0.866 rs9826419 chr3:40352051 G/A cg09455208 chr3:40491958 NA 0.46 7.61 0.42 4.93e-13 Renal cell carcinoma; CESC cis rs2404602 0.709 rs11072591 chr15:76649562 A/G cg23625390 chr15:77176239 SCAPER 0.41 5.66 0.33 3.94e-8 Blood metabolite levels; CESC cis rs208520 0.690 rs207118 chr6:66788948 T/A cg07460842 chr6:66804631 NA -1.0 -13.33 -0.63 2.21e-31 Exhaled nitric oxide output; CESC cis rs6942756 1.000 rs1473236 chr7:128880831 G/T cg02491457 chr7:128862824 NA -0.69 -9.9 -0.52 7.04e-20 White matter hyperintensity burden; CESC cis rs9649465 0.561 rs609953 chr7:123422444 T/A cg03229431 chr7:123269106 ASB15 0.42 5.69 0.33 3.28e-8 Migraine; CESC cis rs6963495 0.818 rs6955796 chr7:105170321 T/G cg02135003 chr7:105160482 PUS7 -0.46 -5.5 -0.32 9.1e-8 Bipolar disorder (body mass index interaction); CESC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.56 0.58 2.62e-25 Platelet count; CESC cis rs9768139 0.524 rs7779175 chr7:158136918 C/T cg06219351 chr7:158114137 PTPRN2 0.53 7.26 0.41 4.21e-12 Calcium levels; CESC cis rs9902453 0.967 rs8067576 chr17:28444254 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.73 0.43 2.21e-13 Coffee consumption (cups per day); CESC cis rs1707322 1.000 rs12133129 chr1:46373348 C/T cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg01238044 chr22:24384105 GSTT1 -0.66 -8.67 -0.47 4.41e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs681343 1.000 rs492602 chr19:49206417 A/G cg21064579 chr19:49206444 FUT2 0.52 7.39 0.41 1.98e-12 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CESC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg05564831 chr3:52568323 NT5DC2 0.45 6.76 0.38 8.65e-11 Bipolar disorder; CESC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg27266027 chr21:40555129 PSMG1 0.44 5.18 0.3 4.48e-7 Cognitive function; CESC cis rs1348850 0.539 rs1453371 chr2:178227862 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.66 8.94 0.48 6.68e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7727544 0.606 rs11950562 chr5:131652529 A/C cg14196790 chr5:131705035 SLC22A5 0.41 6.29 0.36 1.34e-9 Blood metabolite levels; CESC cis rs6430585 0.528 rs12464050 chr2:136663110 G/T cg07169764 chr2:136633963 MCM6 1.23 16.56 0.71 8.67e-43 Corneal structure; CESC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.17e-9 Developmental language disorder (linguistic errors); CESC cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg00290607 chr11:67383545 NA -0.38 -5.33 -0.31 2.09e-7 Mean corpuscular volume; CESC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.66 -9.18 -0.49 1.25e-17 Alzheimer's disease; CESC cis rs6545883 0.929 rs2593627 chr2:61618574 T/C cg15711740 chr2:61764176 XPO1 0.39 5.03 0.3 9.02e-7 Tuberculosis; CESC cis rs6088590 0.561 rs11167239 chr20:33140472 G/A cg24642439 chr20:33292090 TP53INP2 0.61 8.15 0.45 1.5e-14 Coronary artery disease; CESC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.2 -0.63 6.43e-31 Developmental language disorder (linguistic errors); CESC cis rs6060717 0.536 rs11699815 chr20:34543125 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.11 -0.4 1.1e-11 Hip circumference adjusted for BMI; CESC cis rs6087990 0.735 rs6087420 chr20:31359391 G/A cg13636640 chr20:31349939 DNMT3B 0.79 13.4 0.64 1.27e-31 Ulcerative colitis; CESC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg00166722 chr3:10149974 C3orf24 0.5 6.31 0.36 1.19e-9 Alzheimer's disease; CESC cis rs858239 0.670 rs6967526 chr7:23159241 C/A cg23682824 chr7:23144976 KLHL7 0.48 6.69 0.38 1.33e-10 Cerebrospinal fluid biomarker levels; CESC cis rs3026101 0.671 rs28437236 chr17:5319214 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.22 0.31 3.64e-7 Body mass index; CESC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.25 0.53 5.39e-21 Prudent dietary pattern; CESC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.75 0.38 9.1e-11 Bipolar disorder; CESC cis rs3741151 0.881 rs79623427 chr11:73094896 C/T cg17517138 chr11:73019481 ARHGEF17 0.98 6.98 0.39 2.4e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs12477438 0.798 rs1349779 chr2:99645055 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.6 -0.55 4.17e-22 Chronic sinus infection; CESC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg10494973 chr17:80897199 TBCD -0.47 -5.88 -0.34 1.24e-8 Breast cancer; CESC cis rs6831352 0.918 rs13112176 chr4:100055825 G/A cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC trans rs11039798 0.623 rs584851 chr11:48416321 A/G cg15704280 chr7:45808275 SEPT13 -0.68 -6.25 -0.36 1.61e-9 Axial length; CESC cis rs7927771 1.000 rs35902101 chr11:47795169 C/T cg18512352 chr11:47633146 NA -0.61 -9.59 -0.51 6.7e-19 Subjective well-being; CESC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4253772 0.678 rs1053332 chr22:46640179 A/G cg24881330 chr22:46731750 TRMU 0.75 8.28 0.45 6.28e-15 LDL cholesterol;Cholesterol, total; CESC cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.24e-9 Extrinsic epigenetic age acceleration; CESC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs6714710 0.603 rs2044459 chr2:98447004 T/C cg26665480 chr2:98280029 ACTR1B 0.6 8.23 0.45 8.31e-15 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg26597838 chr10:835615 NA 1.18 11.47 0.58 5.21e-25 Eosinophil percentage of granulocytes; CESC cis rs909674 0.690 rs1972280 chr22:39831986 T/A cg02038168 chr22:39784481 NA -0.66 -8.65 -0.47 5.03e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs2404602 0.692 rs34478400 chr15:76923510 C/T cg22467129 chr15:76604101 ETFA -0.36 -5.32 -0.31 2.25e-7 Blood metabolite levels; CESC cis rs10851478 0.872 rs12902960 chr15:49925041 T/C cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.2 0.3 3.95e-7 Oral cavity cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02111299 chr17:17068273 MPRIP 0.42 6.0 0.35 6.4e-9 Fibrinogen levels; CESC cis rs17376456 0.877 rs10476598 chr5:93367281 C/T cg25358565 chr5:93447407 FAM172A -1.1 -11.03 -0.56 1.54e-23 Diabetic retinopathy; CESC cis rs7259376 0.905 rs1975172 chr19:22534603 A/G cg02657401 chr19:22469223 NA -0.28 -5.42 -0.32 1.34e-7 Menopause (age at onset); CESC cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg23711669 chr6:146136114 FBXO30 0.99 15.01 0.68 2.93e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.51 6.48 0.37 4.48e-10 Personality dimensions; CESC cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg04450456 chr4:17643702 FAM184B 0.36 5.06 0.3 7.87e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.36 -0.31 1.8e-7 Developmental language disorder (linguistic errors); CESC cis rs2742234 0.541 rs7098236 chr10:43740508 T/C cg07801480 chr10:43725741 RASGEF1A -0.41 -5.21 -0.3 3.75e-7 Hirschsprung disease; CESC cis rs79057730 0.599 rs6951032 chr7:794092 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.87 7.2 0.4 6.39e-12 Initial pursuit acceleration; CESC cis rs4141404 0.851 rs9606833 chr22:31750013 T/C cg13145458 chr22:31556086 RNF185 -0.58 -6.16 -0.35 2.68e-9 Paclitaxel-induced neuropathy; CESC cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg18016565 chr1:150552671 MCL1 -0.35 -5.82 -0.34 1.73e-8 Tonsillectomy; CESC cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC cis rs921968 0.643 rs2278529 chr2:219502132 C/T cg02176678 chr2:219576539 TTLL4 0.35 6.13 0.35 3.16e-9 Mean corpuscular hemoglobin concentration; CESC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg12463550 chr7:65579703 CRCP 0.59 7.52 0.42 8.29e-13 Aortic root size; CESC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg25405998 chr7:65216604 CCT6P1 0.46 5.11 0.3 6.26e-7 Aortic root size; CESC cis rs473651 0.935 rs515412 chr2:239345394 A/T cg21699342 chr2:239360505 ASB1 0.46 7.59 0.42 5.56e-13 Multiple system atrophy; CESC cis rs8114671 0.562 rs725521 chr20:33516071 T/C cg07148914 chr20:33460835 GGT7 0.46 6.13 0.35 3.19e-9 Height; CESC trans rs9325144 0.555 rs2387855 chr12:38687964 T/G cg23762105 chr12:34175262 ALG10 -0.46 -6.15 -0.35 2.77e-9 Morning vs. evening chronotype; CESC cis rs2070488 0.804 rs13063978 chr3:38476538 A/G cg24069376 chr3:38537580 EXOG 0.35 5.92 0.34 9.72e-9 Electrocardiographic conduction measures; CESC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg24829409 chr8:58192753 C8orf71 -0.69 -7.68 -0.43 3.13e-13 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg26587870 chr6:27730563 NA -0.59 -5.26 -0.31 3e-7 Depression; CESC cis rs8133932 0.654 rs425232 chr21:47346525 G/T cg14185626 chr21:47401492 COL6A1 -0.48 -5.33 -0.31 2.07e-7 Schizophrenia; CESC cis rs7089973 0.604 rs7897937 chr10:116591318 A/G cg23260525 chr10:116636907 FAM160B1 0.4 7.19 0.4 6.76e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg24675658 chr1:53192096 ZYG11B 0.6 7.55 0.42 7.13e-13 Monocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05714672 chr3:15469004 METTL6;EAF1 -0.4 -6.02 -0.35 5.94e-9 Gambling; CESC cis rs738322 0.839 rs9607517 chr22:38596100 G/A cg25457927 chr22:38595422 NA 0.35 6.58 0.37 2.47e-10 Cutaneous nevi; CESC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.29 0.36 1.31e-9 Cystic fibrosis severity; CESC cis rs9811920 0.809 rs6440967 chr3:99722396 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.43 7.18 0.4 7.21e-12 Axial length; CESC cis rs3087591 0.879 rs59015798 chr17:29580882 G/A cg24425628 chr17:29625626 OMG;NF1 -0.44 -5.09 -0.3 6.75e-7 Hip circumference; CESC cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg22307297 chr20:60903441 LAMA5 0.4 5.38 0.31 1.62e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs6502050 0.835 rs11077971 chr17:80090629 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.16 -0.3 4.95e-7 Life satisfaction; CESC cis rs367943 0.712 rs7734061 chr5:112700175 A/G cg12552261 chr5:112820674 MCC 0.42 5.54 0.32 7.2e-8 Type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07156929 chr6:34856927 ANKS1A;TAF11 -0.46 -6.05 -0.35 4.79e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01027365 chr2:191184571 HIBCH 0.59 6.92 0.39 3.34e-11 Gut microbiome composition (summer); CESC cis rs916888 0.773 rs169201 chr17:44790203 A/G cg15921436 chr17:44337874 NA 0.74 7.76 0.43 1.82e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg06970220 chr1:156163860 SLC25A44 0.39 5.18 0.3 4.32e-7 Testicular germ cell tumor; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg21271767 chr15:63449808 RPS27L -0.47 -6.23 -0.36 1.82e-9 Recombination measurement; CESC cis rs2439831 0.557 rs13329084 chr15:44151063 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.7 -6.98 -0.39 2.43e-11 Lung cancer in ever smokers; CESC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg11494091 chr17:61959527 GH2 0.73 12.49 0.61 1.88e-28 Prudent dietary pattern; CESC cis rs8070740 0.617 rs1058115 chr17:5323269 A/G cg25236894 chr17:5323110 RPAIN;NUP88 -0.54 -7.39 -0.41 1.95e-12 Menopause (age at onset); CESC cis rs2404602 0.692 rs7163397 chr15:76940315 A/G cg22467129 chr15:76604101 ETFA -0.35 -5.15 -0.3 5.1e-7 Blood metabolite levels; CESC cis rs5753037 0.653 rs131271 chr22:30151582 A/G cg01021169 chr22:30184971 ASCC2 -0.44 -6.2 -0.36 2.12e-9 Type 1 diabetes; CESC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg22800045 chr5:56110881 MAP3K1 0.51 6.16 0.35 2.73e-9 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15120237 chr17:7747620 KDM6B -0.47 -6.73 -0.38 1.02e-10 Gambling; CESC cis rs17376456 0.877 rs34673483 chr5:93315079 C/A cg25358565 chr5:93447407 FAM172A 1.1 10.7 0.55 1.98e-22 Diabetic retinopathy; CESC cis rs344364 0.511 rs911392 chr16:1947259 A/G cg03013636 chr16:1946785 NA 0.46 6.4 0.37 7.09e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs116095464 0.558 rs7713524 chr5:276200 C/T cg12570787 chr5:219185 SDHA;CCDC127 -0.53 -5.63 -0.33 4.62e-8 Breast cancer; CESC cis rs9486719 0.857 rs9285393 chr6:97020917 C/A cg06623918 chr6:96969491 KIAA0776 -0.75 -8.14 -0.45 1.51e-14 Migraine;Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25430995 chr10:73611082 PSAP 0.55 6.5 0.37 3.89e-10 Gut microbiome composition (summer); CESC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg06873352 chr17:61820015 STRADA 0.74 13.19 0.63 7.17e-31 Prudent dietary pattern; CESC cis rs17376456 0.825 rs6877030 chr5:93201841 C/A cg21475434 chr5:93447410 FAM172A 0.84 7.45 0.42 1.35e-12 Diabetic retinopathy; CESC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg22907277 chr7:1156413 C7orf50 0.45 5.11 0.3 6.12e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4268898 0.560 rs78711174 chr2:24496531 G/A cg20701182 chr2:24300061 SF3B14 0.62 6.64 0.38 1.81e-10 Asthma; CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg24503407 chr1:205819492 PM20D1 0.92 16.78 0.72 1.49e-43 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04050850 chr2:219536800 STK36;RNF25 0.53 6.1 0.35 3.75e-9 Gut microbiome composition (summer); CESC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg00800038 chr16:89945340 TCF25 -0.92 -7.62 -0.42 4.38e-13 Skin colour saturation; CESC trans rs561341 1.000 rs554078 chr17:30330109 A/C cg27661571 chr11:113659931 NA -0.87 -8.03 -0.44 3.16e-14 Hip circumference adjusted for BMI; CESC cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg04455712 chr21:45112962 RRP1B 0.46 7.4 0.41 1.77e-12 Mean corpuscular volume; CESC trans rs208520 0.837 rs208489 chr6:66927584 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -9.9 -0.52 7.1e-20 Exhaled nitric oxide output; CESC cis rs61841072 1.000 rs61841073 chr1:243129519 A/G cg02356786 chr1:243265016 LOC731275 0.41 5.26 0.31 2.97e-7 Schizophrenia; CESC cis rs7927771 0.965 rs1064608 chr11:47640429 G/C cg18512352 chr11:47633146 NA -0.63 -10.06 -0.53 2.25e-20 Subjective well-being; CESC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg21951975 chr1:209979733 IRF6 0.62 7.75 0.43 2.01e-13 Cleft lip with or without cleft palate; CESC cis rs9549260 0.560 rs61963353 chr13:41327301 C/T cg21288729 chr13:41239152 FOXO1 0.63 5.24 0.31 3.36e-7 Red blood cell count; CESC cis rs6541297 1.000 rs4846909 chr1:230285372 G/A cg20703242 chr1:230279135 GALNT2 0.72 11.12 0.56 8.03e-24 Coronary artery disease; CESC cis rs10905065 1.000 rs10795488 chr10:5755207 C/A cg11519256 chr10:5708881 ASB13 0.43 5.59 0.32 5.52e-8 Menopause (age at onset); CESC cis rs12079745 0.793 rs3766094 chr1:169288264 T/A cg09363564 chr1:169337483 NME7;BLZF1 -1.0 -5.7 -0.33 3.17e-8 QT interval; CESC cis rs35123781 1.000 rs34510678 chr5:139064835 C/T cg10513866 chr5:139070639 NA 0.39 5.75 0.33 2.41e-8 Schizophrenia; CESC cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg03433033 chr1:76189801 ACADM 0.7 9.38 0.5 2.99e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs12136530 0.774 rs10442635 chr1:19775492 C/T cg01832549 chr1:19774989 CAPZB 0.4 5.81 0.34 1.75e-8 Lead levels in blood; CESC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC trans rs9325144 0.560 rs7980358 chr12:38640396 C/G cg23762105 chr12:34175262 ALG10 -0.48 -6.25 -0.36 1.63e-9 Morning vs. evening chronotype; CESC cis rs748404 0.601 rs489964 chr15:43517554 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.43 -5.18 -0.3 4.34e-7 Lung cancer; CESC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg17971929 chr21:40555470 PSMG1 1.04 16.4 0.71 3.38e-42 Cognitive function; CESC cis rs4891159 0.548 rs660342 chr18:74130896 C/G cg24786174 chr18:74118243 ZNF516 0.83 15.82 0.7 3.9e-40 Longevity; CESC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg08736216 chr1:53307985 ZYG11A -0.39 -6.42 -0.37 6.21e-10 Monocyte count; CESC cis rs8005677 1.000 rs4981446 chr14:23381413 A/G cg25600027 chr14:23388339 RBM23 -0.43 -5.33 -0.31 2.08e-7 Cognitive ability (multi-trait analysis); CESC trans rs1814175 0.817 rs4881623 chr11:49804991 C/T cg03929089 chr4:120376271 NA -0.9 -14.97 -0.68 4.06e-37 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05606948 chr13:24408286 MIPEP -0.6 -6.46 -0.37 4.98e-10 Gut microbiome composition (summer); CESC cis rs631288 0.793 rs894473 chr1:146687789 A/G cg25205988 chr1:146714368 CHD1L 1.17 6.69 0.38 1.34e-10 PR interval in Tripanosoma cruzi seropositivity; CESC trans rs11098499 0.863 rs34868248 chr4:120442430 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.63 0.51 5.06e-19 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15793417 chr19:38573135 SIPA1L3 -0.56 -6.7 -0.38 1.23e-10 Gut microbiome composition (summer); CESC cis rs2073300 0.609 rs2281428 chr20:23400050 C/T cg12062639 chr20:23401060 NAPB 1.08 8.41 0.46 2.6e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs2207136 0.868 rs9381906 chr6:50830691 G/T cg06522515 chr3:184090630 THPO -0.38 -6.63 -0.38 1.9e-10 Myopia; CESC cis rs9682041 0.696 rs11927807 chr3:170096623 A/G cg11886554 chr3:170076028 SKIL 0.7 6.46 0.37 4.94e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs208520 0.690 rs7764570 chr6:66827600 G/C cg07460842 chr6:66804631 NA -0.84 -11.39 -0.57 9.72e-25 Exhaled nitric oxide output; CESC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg22535103 chr8:58192502 C8orf71 -0.81 -9.14 -0.49 1.65e-17 Developmental language disorder (linguistic errors); CESC cis rs6463523 0.898 rs66892628 chr7:759374 T/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.96 14.73 0.67 2.83e-36 Subjective well-being; CESC cis rs1475911 0.708 rs8129075 chr21:43523430 G/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.55 -8.53 -0.46 1.18e-15 IgG glycosylation; CESC cis rs4843747 0.671 rs72818577 chr16:88111181 G/A cg17633681 chr16:88106987 BANP 0.76 10.48 0.54 1.02e-21 Menopause (age at onset); CESC cis rs9486715 0.867 rs1855533 chr6:97050265 T/C cg18709589 chr6:96969512 KIAA0776 -0.45 -6.21 -0.36 2.05e-9 Headache; CESC cis rs644799 1.000 rs611020 chr11:95567905 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.49 0.37 4.26e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10870270 1.000 rs9971066 chr10:133788233 G/A cg26149184 chr10:133730230 NA 0.4 5.42 0.32 1.35e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs6754311 0.731 rs2322660 chr2:136557319 A/G cg07169764 chr2:136633963 MCM6 0.67 8.2 0.45 1.03e-14 Mosquito bite size; CESC cis rs7178909 0.872 rs61345389 chr15:90435885 T/C cg19708238 chr15:90437601 AP3S2 0.43 6.23 0.36 1.86e-9 Common traits (Other); CESC cis rs6060717 0.653 rs2590962 chr20:34615363 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -7.86 -0.43 9.46e-14 Hip circumference adjusted for BMI; CESC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg06481639 chr22:41940642 POLR3H -0.62 -6.41 -0.37 6.55e-10 Vitiligo; CESC cis rs4927850 0.709 rs6765762 chr3:195652851 G/A cg01181863 chr3:195395398 SDHAP2 -0.69 -7.75 -0.43 1.94e-13 Pancreatic cancer; CESC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg20203395 chr5:56204925 C5orf35 -0.43 -5.21 -0.3 3.87e-7 Type 2 diabetes; CESC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg12963246 chr6:28129442 ZNF389 0.5 6.4 0.37 6.93e-10 Parkinson's disease; CESC cis rs11997175 0.624 rs4355732 chr8:33676920 A/C ch.8.33884649F chr8:33765107 NA 0.58 7.4 0.41 1.85e-12 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04141094 chr2:54785178 SPTBN1 -0.45 -6.07 -0.35 4.5e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6952809 0.516 rs6952959 chr7:2440722 C/T cg23289794 chr7:2394357 EIF3B -0.79 -7.29 -0.41 3.64e-12 Multiple sclerosis; CESC cis rs5167 0.506 rs7257916 chr19:45482884 T/C cg09555818 chr19:45449301 APOC2 -0.47 -6.99 -0.39 2.26e-11 Blood protein levels; CESC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg15445000 chr17:37608096 MED1 -0.41 -6.81 -0.39 6.37e-11 Glomerular filtration rate (creatinine); CESC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg18357526 chr6:26021779 HIST1H4A 0.7 9.42 0.5 2.24e-18 Intelligence (multi-trait analysis); CESC cis rs7937682 0.564 rs10891277 chr11:111373103 A/G cg09085632 chr11:111637200 PPP2R1B 0.45 5.45 0.32 1.15e-7 Primary sclerosing cholangitis; CESC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.44 0.61 2.67e-28 Gut microbiome composition (summer); CESC cis rs8031584 1.000 rs35607976 chr15:31277788 T/C cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.16 -0.3 4.81e-7 Huntington's disease progression; CESC cis rs73110464 0.609 rs4919752 chr12:53359229 G/C cg14581129 chr12:53358946 NA -0.58 -7.84 -0.43 1.07e-13 Cancer (pleiotropy); CESC cis rs9640161 0.830 rs7800196 chr7:150061534 C/G cg27494647 chr7:150038898 RARRES2 0.42 5.9 0.34 1.1e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg06494592 chr3:125709126 NA -0.51 -5.51 -0.32 8.32e-8 Blood pressure (smoking interaction); CESC cis rs863345 0.967 rs12080815 chr1:158533140 A/G cg12129480 chr1:158549410 OR10X1 -0.31 -6.6 -0.38 2.22e-10 Pneumococcal bacteremia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15008879 chr10:22292810 DNAJC1 0.52 6.75 0.38 9.45e-11 Gut microbiota (bacterial taxa); CESC trans rs9856151 1.000 rs13063979 chr3:131564741 G/T cg07970948 chr7:149543165 ZNF862 -0.47 -6.02 -0.35 5.73e-9 Body mass index; CESC trans rs1814175 0.817 rs10839401 chr11:49876144 C/T cg03929089 chr4:120376271 NA -0.9 -14.88 -0.67 8.24e-37 Height; CESC cis rs6598955 0.671 rs58038522 chr1:26582713 C/T cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23561934 chr2:121199920 NA 0.57 6.39 0.37 7.25e-10 Gut microbiome composition (summer); CESC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg15369054 chr17:80825471 TBCD 0.57 7.96 0.44 5.16e-14 Breast cancer; CESC cis rs8070740 1.000 rs4790772 chr17:5330959 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.56 6.77 0.38 8.23e-11 Menopause (age at onset); CESC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03800765 chr3:11313984 ATG7 0.56 6.14 0.35 3.02e-9 Gut microbiome composition (summer); CESC cis rs77741769 0.571 rs11065300 chr12:121298512 G/C cg02419362 chr12:121203948 SPPL3 0.34 5.59 0.32 5.6e-8 Mean corpuscular volume; CESC cis rs1499972 0.938 rs2925312 chr3:117720473 C/T cg07612923 chr3:117604196 NA -0.77 -5.71 -0.33 3.06e-8 Schizophrenia; CESC cis rs9868809 0.881 rs7631574 chr3:48663046 A/G cg07636037 chr3:49044803 WDR6 0.62 5.71 0.33 3e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs933688 1.000 rs6867219 chr5:90718008 T/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 12.44 0.61 2.82e-28 Smoking behavior; CESC cis rs2731664 0.756 rs4976695 chr5:176862963 T/A cg23176889 chr5:176863531 GRK6 -0.64 -10.92 -0.56 3.67e-23 Intelligence (multi-trait analysis); CESC cis rs7772486 0.846 rs9373482 chr6:146363123 A/C cg23711669 chr6:146136114 FBXO30 0.85 12.56 0.61 1.02e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs116988415 0.584 rs2269306 chr14:65245417 A/G cg25083366 chr14:65239357 SPTB -0.67 -5.04 -0.3 8.56e-7 Daytime sleep phenotypes; CESC cis rs34779708 0.931 rs4934697 chr10:35287192 C/T cg04310649 chr10:35416472 CREM -0.49 -5.91 -0.34 1.03e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs17023223 0.508 rs12096448 chr1:119683390 G/A cg05756136 chr1:119680316 WARS2 -0.45 -5.42 -0.32 1.31e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs2204008 0.777 rs11179774 chr12:38219559 A/C cg13010199 chr12:38710504 ALG10B 0.53 6.65 0.38 1.69e-10 Bladder cancer; CESC cis rs13191362 0.935 rs34268859 chr6:162934731 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.73 6.4 0.37 6.88e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9902453 0.845 rs10853135 chr17:28188675 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.21 0.45 9.9e-15 Coffee consumption (cups per day); CESC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Depression; CESC cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg22496339 chr2:162101262 NA -0.51 -6.71 -0.38 1.2e-10 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26773803 chr7:148958927 ZNF783 0.55 6.51 0.37 3.7e-10 Gut microbiome composition (summer); CESC trans rs10242455 0.571 rs45593341 chr7:99304911 C/A cg09045935 chr12:6379348 NA 0.78 6.33 0.36 1.07e-9 Blood metabolite levels; CESC cis rs8005677 1.000 rs1043209 chr14:23373986 A/G cg01529538 chr14:23388837 RBM23 -0.53 -7.13 -0.4 9.35e-12 Cognitive ability (multi-trait analysis); CESC cis rs12048904 0.595 rs2295280 chr1:101342497 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.66 9.55 0.51 9.28e-19 Multiple sclerosis; CESC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg25072359 chr17:41440525 NA 0.43 5.78 0.33 2.04e-8 Menopause (age at onset); CESC cis rs9303401 0.659 rs34426768 chr17:56683385 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.02 11.73 0.58 7.25e-26 Cognitive test performance; CESC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg09658497 chr7:2847517 GNA12 -0.39 -5.53 -0.32 7.81e-8 Height; CESC cis rs962856 0.756 rs4671800 chr2:67622348 T/C cg09028215 chr2:67624308 ETAA1 -0.44 -5.6 -0.33 5.35e-8 Pancreatic cancer; CESC trans rs35110281 0.627 rs7283362 chr21:44973667 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 7.11 0.4 1.09e-11 Mean corpuscular volume; CESC cis rs8114671 0.562 rs6087653 chr20:33522054 T/C cg07148914 chr20:33460835 GGT7 0.46 6.13 0.35 3.19e-9 Height; CESC cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg08847533 chr14:75593920 NEK9 -0.98 -17.76 -0.74 5e-47 Height; CESC cis rs72781680 1.000 rs55773155 chr2:24255081 A/G cg08917208 chr2:24149416 ATAD2B 1.06 8.75 0.47 2.62e-16 Lymphocyte counts; CESC cis rs9399135 0.967 rs7773126 chr6:135318390 A/G cg22676075 chr6:135203613 NA 0.5 6.87 0.39 4.48e-11 Red blood cell count; CESC cis rs963731 0.579 rs1454220 chr2:39277108 G/A cg04010122 chr2:39346883 SOS1 -0.71 -5.66 -0.33 3.89e-8 Corticobasal degeneration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10083149 chr2:3321068 TSSC1 -0.64 -7.44 -0.42 1.43e-12 Gut microbiome composition (summer); CESC cis rs728616 0.764 rs56122289 chr10:81746027 G/A cg05935833 chr10:81318306 SFTPA2 -0.54 -5.16 -0.3 4.93e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs11608355 0.515 rs7976796 chr12:109928013 C/T cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs7772486 0.790 rs9497431 chr6:146248177 T/C cg05347473 chr6:146136440 FBXO30 -0.55 -7.03 -0.4 1.78e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs16957304 1.000 rs16957304 chr16:67334969 C/T cg01866162 chr16:67596514 CTCF -0.73 -5.2 -0.3 3.9e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg03060546 chr3:49711283 APEH -0.51 -6.94 -0.39 3.07e-11 Menarche (age at onset); CESC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC cis rs72781680 0.898 rs56216411 chr2:23934533 G/A cg08917208 chr2:24149416 ATAD2B 1.1 10.15 0.53 1.18e-20 Lymphocyte counts; CESC cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.27 0.6 1.03e-27 Colonoscopy-negative controls vs population controls; CESC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg06877462 chr1:205807181 PM20D1 0.39 5.82 0.34 1.69e-8 Menarche (age at onset); CESC cis rs28647808 1.000 rs28690644 chr9:136269669 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs858239 0.539 rs4295546 chr7:23191021 C/T cg23682824 chr7:23144976 KLHL7 0.49 6.46 0.37 5.12e-10 Cerebrospinal fluid biomarker levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23396974 chr7:45151349 TBRG4 0.58 6.31 0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs959260 1.000 rs4789181 chr17:73374640 T/A cg12999837 chr17:73267436 MIF4GD -0.51 -5.8 -0.34 1.91e-8 Systemic lupus erythematosus; CESC cis rs10927875 0.541 rs1048237 chr1:16341733 T/C cg22431228 chr1:16359049 CLCNKA -0.52 -9.9 -0.52 7.22e-20 Dilated cardiomyopathy; CESC trans rs1814175 0.791 rs11040513 chr11:49778153 G/C cg03929089 chr4:120376271 NA -0.9 -14.97 -0.68 4.06e-37 Height; CESC cis rs11098499 0.865 rs28634456 chr4:120375778 A/G cg09307838 chr4:120376055 NA 0.93 13.29 0.63 3.24e-31 Corneal astigmatism; CESC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg17724175 chr1:150552817 MCL1 0.33 5.23 0.31 3.44e-7 Melanoma; CESC cis rs17376456 1.000 rs12187701 chr5:93522290 A/G cg21475434 chr5:93447410 FAM172A 0.9 7.81 0.43 1.38e-13 Diabetic retinopathy; CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg09033563 chr22:24373618 LOC391322 -0.52 -7.07 -0.4 1.36e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg07395648 chr5:131743802 NA 0.41 5.35 0.31 1.86e-7 Blood metabolite levels; CESC cis rs12477438 0.765 rs62154861 chr2:99590235 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.73 -10.26 -0.53 5.33e-21 Chronic sinus infection; CESC cis rs3760982 0.565 rs8104300 chr19:44293144 T/C cg11993925 chr19:44307056 LYPD5 0.32 5.39 0.31 1.57e-7 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs34638657 0.827 rs3829548 chr16:82206238 C/G cg07918374 chr16:82182319 MPHOSPH6 -0.62 -7.49 -0.42 1.06e-12 Lung adenocarcinoma; CESC cis rs2415984 0.600 rs61993295 chr14:46932614 T/C cg14871534 chr14:47121158 RPL10L -0.34 -5.14 -0.3 5.44e-7 Number of children ever born; CESC cis rs7216064 1.000 rs6504555 chr17:65940727 A/G cg12091567 chr17:66097778 LOC651250 0.71 8.07 0.44 2.47e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4481887 0.893 rs4244186 chr1:248493319 A/G cg00666640 chr1:248458726 OR2T12 0.36 6.17 0.35 2.56e-9 Common traits (Other); CESC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.73 -0.33 2.72e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs67460515 0.892 rs11718905 chr3:161051793 G/A cg03342759 chr3:160939853 NMD3 -0.52 -7.26 -0.41 4.28e-12 Parkinson's disease; CESC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.53 7.88 0.44 8.44e-14 Bipolar disorder; CESC cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.55 0.32 6.89e-8 Diabetic retinopathy; CESC cis rs9611565 0.545 rs5758432 chr22:42111693 T/C cg06481639 chr22:41940642 POLR3H 0.62 6.06 0.35 4.57e-9 Vitiligo; CESC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg27532560 chr4:187881888 NA -0.4 -6.14 -0.35 2.92e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs2011503 0.941 rs56278919 chr19:19367190 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 5.06 0.3 7.87e-7 Bipolar disorder; CESC cis rs9467773 0.595 rs7767847 chr6:26597893 A/T cg20266910 chr6:26577678 NA 0.35 5.85 0.34 1.44e-8 Intelligence (multi-trait analysis); CESC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg06492744 chr11:65406254 SIPA1 0.42 5.09 0.3 6.67e-7 Blood pressure (age interaction); CESC cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg03467027 chr4:99064603 C4orf37 0.48 5.98 0.35 7.02e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6831352 0.918 rs35662508 chr4:100050974 C/G cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs7255436 0.965 rs7249624 chr19:8446135 G/A cg10174797 chr19:8464628 RAB11B 0.41 5.96 0.34 8.11e-9 HDL cholesterol; CESC cis rs3820928 0.874 rs10166456 chr2:227900113 G/A cg11843606 chr2:227700838 RHBDD1 -0.48 -6.43 -0.37 5.78e-10 Pulmonary function; CESC cis rs9527 0.615 rs11191401 chr10:104573403 A/G cg04362960 chr10:104952993 NT5C2 0.45 5.32 0.31 2.2e-7 Arsenic metabolism; CESC cis rs7760535 0.656 rs7766190 chr6:111905066 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.34 -5.38 -0.31 1.66e-7 Metabolic traits; CESC cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg19052272 chr2:3704530 ALLC -0.5 -5.83 -0.34 1.64e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs34779708 0.966 rs35146199 chr10:35460939 T/C cg04310649 chr10:35416472 CREM -0.51 -6.2 -0.36 2.13e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs3780486 1.000 rs10813951 chr9:33128021 C/T cg20290983 chr6:43655470 MRPS18A -0.86 -12.61 -0.61 6.96e-29 IgG glycosylation; CESC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg04414720 chr1:150670196 GOLPH3L 0.45 5.92 0.34 1.01e-8 Melanoma; CESC cis rs881375 0.654 rs10760126 chr9:123662618 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.63 0.42 4.26e-13 Rheumatoid arthritis; CESC trans rs9929218 0.954 rs4552018 chr16:68822854 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.13 -0.45 1.69e-14 Colorectal cancer; CESC cis rs4780401 0.933 rs12926451 chr16:11819569 A/C cg01061890 chr16:11836724 TXNDC11 0.4 5.32 0.31 2.26e-7 Rheumatoid arthritis; CESC cis rs911186 0.740 rs6938200 chr6:27231150 A/G cg12292205 chr6:26970375 C6orf41 -0.57 -5.99 -0.35 6.8e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2635047 0.811 rs9965170 chr18:44788274 C/T cg24371990 chr18:44770781 NA 0.39 6.31 0.36 1.14e-9 Educational attainment; CESC cis rs10899021 1.000 rs11236190 chr11:74366755 G/T cg25880958 chr11:74394337 NA -0.79 -6.51 -0.37 3.71e-10 Response to metformin (IC50); CESC cis rs7937682 0.855 rs571462 chr11:111487106 C/G cg22437258 chr11:111473054 SIK2 0.72 9.66 0.51 4.24e-19 Primary sclerosing cholangitis; CESC cis rs12458462 0.892 rs2242174 chr18:77458037 T/C cg23301140 chr18:77439876 CTDP1 0.56 7.5 0.42 9.67e-13 Monocyte count; CESC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg05340658 chr4:99064831 C4orf37 0.85 12.97 0.62 4.01e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.66 9.22 0.49 9.73e-18 Menopause (age at onset); CESC cis rs897984 0.609 rs732173 chr16:31050023 C/A cg02466173 chr16:30829666 NA -0.44 -7.68 -0.43 3.08e-13 Dementia with Lewy bodies; CESC cis rs963731 0.579 rs1377863 chr2:39238854 T/C cg04010122 chr2:39346883 SOS1 -0.59 -5.23 -0.31 3.39e-7 Corticobasal degeneration; CESC cis rs11792861 0.926 rs12686736 chr9:111888739 A/G cg05043794 chr9:111880884 C9orf5 -0.43 -7.08 -0.4 1.3e-11 Menarche (age at onset); CESC cis rs763014 0.966 rs7198877 chr16:661439 A/G cg07343612 chr16:622815 PIGQ -0.56 -8.17 -0.45 1.28e-14 Height; CESC cis rs3825932 0.961 rs11856301 chr15:79232330 T/C cg25744700 chr15:79237217 CTSH 0.48 6.58 0.37 2.45e-10 Type 1 diabetes; CESC cis rs2243480 1.000 rs313799 chr7:65494330 A/G cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC cis rs6142102 0.602 rs2300209 chr20:32643100 T/C cg08999081 chr20:33150536 PIGU 0.33 5.13 0.3 5.64e-7 Skin pigmentation; CESC cis rs7927771 0.524 rs4539273 chr11:47694699 C/T cg18512352 chr11:47633146 NA -0.37 -5.73 -0.33 2.74e-8 Subjective well-being; CESC cis rs2204008 0.660 rs2874343 chr12:38239096 C/T cg26384229 chr12:38710491 ALG10B 0.73 10.35 0.54 2.55e-21 Bladder cancer; CESC trans rs1728785 0.901 rs933713 chr16:68581378 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg20151795 chr6:28129481 ZNF389 0.46 5.83 0.34 1.65e-8 Depression; CESC trans rs11098499 0.691 rs9995716 chr4:120264996 T/C cg25214090 chr10:38739885 LOC399744 0.6 8.26 0.45 6.87e-15 Corneal astigmatism; CESC cis rs8070624 0.502 rs12951376 chr17:17752809 C/T cg04398451 chr17:18023971 MYO15A -0.58 -7.73 -0.43 2.18e-13 Total body bone mineral density; CESC cis rs2282802 0.685 rs2337081 chr5:139642414 A/C cg26211634 chr5:139558579 C5orf32 0.53 7.66 0.43 3.55e-13 Intelligence (multi-trait analysis); CESC cis rs1401999 0.966 rs2292998 chr3:183663833 T/C cg01324343 chr3:183735012 ABCC5 0.63 13.49 0.64 6.42e-32 Anterior chamber depth; CESC cis rs2012796 0.661 rs59969857 chr14:81841579 A/G cg02996355 chr14:81879375 NA 0.62 7.59 0.42 5.34e-13 Night sleep phenotypes; CESC cis rs4423214 0.879 rs1792283 chr11:71135136 T/C cg05163923 chr11:71159392 DHCR7 -0.59 -6.82 -0.39 6e-11 Vitamin D levels; CESC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs1580019 0.813 rs2044839 chr7:32500805 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.9 12.81 0.62 1.49e-29 Cognitive ability; CESC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg04025307 chr7:1156635 C7orf50 0.46 7.33 0.41 2.78e-12 Longevity;Endometriosis; CESC cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg23158103 chr7:148848205 ZNF398 -0.35 -5.22 -0.31 3.65e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs35110281 0.565 rs7278003 chr21:44966069 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 8.09 0.45 2.12e-14 Mean corpuscular volume; CESC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg01341218 chr17:43662625 NA -0.85 -10.25 -0.53 5.55e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2072732 0.904 rs2993481 chr1:2973433 A/T cg03976712 chr1:2946727 NA 0.32 5.2 0.3 3.99e-7 Plateletcrit; CESC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg18350739 chr11:68623251 NA -0.44 -6.45 -0.37 5.25e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4242434 0.927 rs35952885 chr8:22491622 T/G cg03733263 chr8:22462867 KIAA1967 0.98 14.23 0.66 1.6e-34 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01380634 chr19:4046108 ZBTB7A -0.54 -6.44 -0.37 5.44e-10 Gut microbiome composition (summer); CESC cis rs10504229 0.679 rs73681882 chr8:58030038 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -5.93 -0.34 9.43e-9 Developmental language disorder (linguistic errors); CESC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg21963583 chr11:68658836 MRPL21 0.42 5.73 0.33 2.78e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg00409905 chr10:38381863 ZNF37A -0.45 -5.96 -0.34 8.1e-9 Extrinsic epigenetic age acceleration; CESC cis rs12950390 0.853 rs8071192 chr17:45856141 A/G cg00777063 chr17:45855553 NA -0.4 -5.8 -0.34 1.84e-8 IgG glycosylation; CESC cis rs2749592 0.505 rs7915670 chr10:37870212 T/C cg00409905 chr10:38381863 ZNF37A 0.43 5.7 0.33 3.24e-8 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17482927 chr17:63133259 RGS9 0.47 6.3 0.36 1.21e-9 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg11941060 chr3:133502564 NA -0.46 -6.46 -0.37 5.02e-10 Iron status biomarkers; CESC cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC cis rs8180040 0.620 rs11709660 chr3:47074927 G/A cg27129171 chr3:47204927 SETD2 -0.66 -9.82 -0.52 1.32e-19 Colorectal cancer; CESC cis rs1003719 0.762 rs34273703 chr21:38475019 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.4 -0.31 1.46e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23411318 chr17:27939327 ANKRD13B 0.46 6.14 0.35 3.09e-9 Fibrinogen levels; CESC cis rs735396 1.000 rs1169306 chr12:121438311 C/T cg25281562 chr12:121454272 C12orf43 0.4 5.17 0.3 4.6e-7 N-glycan levels; CESC cis rs12586317 0.547 rs28589276 chr14:35478865 A/G cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC cis rs6570726 0.935 rs12663205 chr6:145818378 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs12928939 0.517 rs8049508 chr16:71978313 C/T cg03805757 chr16:71968109 PKD1L3 -0.56 -6.33 -0.36 1.04e-9 Post bronchodilator FEV1; CESC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg24399712 chr22:39784796 NA -0.83 -10.98 -0.56 2.21e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg04772025 chr11:68637568 NA 0.51 6.18 0.36 2.36e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg27503950 chr6:160024002 NA 0.35 5.08 0.3 7.22e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs8112211 0.816 rs80248244 chr19:38841714 A/C cg14299480 chr19:38876666 GGN -0.43 -5.28 -0.31 2.74e-7 Blood protein levels; CESC cis rs13130787 0.606 rs13134681 chr4:94943706 C/T cg11021082 chr4:95130006 SMARCAD1 0.42 5.88 0.34 1.25e-8 Colorectal cancer; CESC cis rs4662945 0.525 rs28819474 chr2:130264623 T/C cg05962382 chr2:130345044 NA -0.47 -7.06 -0.4 1.47e-11 Response to cytidine analogues (gemcitabine); CESC cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg15017067 chr4:17643749 FAM184B 0.37 5.2 0.3 3.95e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1949733 1.000 rs2631745 chr4:8490530 T/C cg11789530 chr4:8429930 ACOX3 -0.79 -11.25 -0.57 2.91e-24 Response to antineoplastic agents; CESC trans rs3784262 0.669 rs3784257 chr15:58262974 C/T cg20199333 chr11:46740790 F2 0.37 6.11 0.35 3.62e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs10911363 0.573 rs2761580 chr1:183516989 A/T cg09173681 chr1:183549694 NCF2 0.52 7.67 0.43 3.24e-13 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg03467027 chr4:99064603 C4orf37 -0.47 -5.95 -0.34 8.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg04166393 chr7:2884313 GNA12 0.6 7.6 0.42 5.22e-13 Height; CESC trans rs7726839 0.540 rs7558 chr5:660491 C/T cg25482853 chr8:67687455 SGK3 0.98 10.12 0.53 1.43e-20 Obesity-related traits; CESC cis rs2204008 0.505 rs11182550 chr12:38570061 A/T cg26384229 chr12:38710491 ALG10B 0.47 6.8 0.39 6.95e-11 Bladder cancer; CESC cis rs17666538 0.585 rs10090260 chr8:608034 T/C cg23958373 chr8:599963 NA 0.85 6.57 0.37 2.69e-10 IgG glycosylation; CESC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg23708337 chr7:1209742 NA 0.54 5.4 0.31 1.48e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4561483 0.831 rs2018199 chr16:11940968 C/T cg08843971 chr16:11963173 GSPT1 -0.38 -5.37 -0.31 1.68e-7 Testicular germ cell tumor; CESC cis rs6543140 0.964 rs6543136 chr2:103065547 G/A cg04239558 chr2:103089729 SLC9A4 0.43 5.39 0.31 1.54e-7 Blood protein levels; CESC cis rs72848980 0.512 rs61151381 chr10:105370496 C/G cg00126946 chr10:105363258 SH3PXD2A 0.6 8.53 0.46 1.14e-15 White matter hyperintensity burden; CESC trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg03929089 chr4:120376271 NA -0.85 -13.4 -0.64 1.35e-31 Coronary artery disease; CESC cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.16e-8 Colonoscopy-negative controls vs population controls; CESC trans rs2066819 1.000 rs808919 chr12:56647911 C/G cg23245485 chr12:6484219 SCNN1A -0.42 -6.0 -0.35 6.62e-9 Psoriasis vulgaris; CESC trans rs8073060 0.614 rs225279 chr17:33974214 A/G cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8027181 0.617 rs4777541 chr15:73082240 C/T cg25632853 chr15:73088954 NA 0.36 5.86 0.34 1.37e-8 Triglyceride levels; CESC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg26839252 chr6:160211577 TCP1;MRPL18 0.46 5.46 0.32 1.12e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs34779708 0.966 rs7077242 chr10:35481965 A/C cg03585969 chr10:35415529 CREM -0.75 -9.82 -0.52 1.3e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.6 0.33 5.36e-8 Menopause (age at onset); CESC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg17971929 chr21:40555470 PSMG1 -0.5 -6.26 -0.36 1.55e-9 Cognitive function; CESC cis rs9329289 0.603 rs2458698 chr10:2548452 C/T cg18171855 chr10:2543474 NA 0.39 5.75 0.33 2.49e-8 Age-related hearing impairment; CESC cis rs731174 0.959 rs11264092 chr1:38190625 T/C cg12339802 chr1:38156545 C1orf109 -0.54 -6.29 -0.36 1.31e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg04267008 chr7:1944627 MAD1L1 -0.65 -8.02 -0.44 3.47e-14 Bipolar disorder and schizophrenia; CESC cis rs2273669 0.667 rs12210444 chr6:109305743 T/C cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC cis rs9549260 0.604 rs9532587 chr13:41302694 A/T cg21288729 chr13:41239152 FOXO1 0.57 5.14 0.3 5.42e-7 Red blood cell count; CESC cis rs1348850 0.645 rs13431091 chr2:178434615 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 6.3 0.36 1.26e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.32 -0.31 2.25e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs2594989 0.895 rs2606759 chr3:11349494 T/C cg00170343 chr3:11313890 ATG7 0.56 5.14 0.3 5.26e-7 Circulating chemerin levels; CESC cis rs11696501 0.739 rs6104250 chr20:44251479 C/T cg11783356 chr20:44313418 WFDC10B -0.35 -5.42 -0.32 1.35e-7 Brain structure; CESC cis rs10089 1.000 rs72794401 chr5:127517626 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.77 9.64 0.51 4.67e-19 Ileal carcinoids; CESC cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 0.82 12.04 0.59 6.48e-27 Systemic lupus erythematosus; CESC cis rs12450688 1 rs12450688 chr17:38144229 G/A cg17467752 chr17:38218738 THRA -0.56 -8.22 -0.45 8.91e-15 Sum eosinophil basophil counts; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26828131 chr1:249106207 SH3BP5L 0.49 6.29 0.36 1.29e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06320606 chr5:60139941 ELOVL7 0.63 7.64 0.42 3.86e-13 Gut microbiome composition (summer); CESC cis rs6546550 0.901 rs6721891 chr2:70146121 A/G cg02498382 chr2:70120550 SNRNP27 -0.41 -7.36 -0.41 2.35e-12 Prevalent atrial fibrillation; CESC cis rs67478160 0.644 rs7159810 chr14:104294117 T/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.1 -0.4 1.12e-11 Schizophrenia; CESC cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg27347728 chr4:17578864 LAP3 0.49 5.63 0.33 4.53e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9640161 0.659 rs11974980 chr7:150009838 C/T cg10018233 chr7:150070692 REPIN1 0.46 7.32 0.41 2.89e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs9457247 0.967 rs2769355 chr6:167380493 G/A cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.65e-7 Crohn's disease; CESC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg18099408 chr3:52552593 STAB1 0.36 5.93 0.34 9.21e-9 Bipolar disorder; CESC cis rs1003719 0.788 rs1155785 chr21:38447939 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.64 0.47 5.56e-16 Eye color traits; CESC cis rs916888 0.773 rs199451 chr17:44801784 G/A cg15921436 chr17:44337874 NA 0.74 7.81 0.43 1.35e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs72781680 0.898 rs113522526 chr2:24018476 C/T cg08917208 chr2:24149416 ATAD2B 0.95 8.55 0.46 1.03e-15 Lymphocyte counts; CESC trans rs116095464 0.558 rs73024831 chr5:257192 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.35e-11 Breast cancer; CESC cis rs1957429 0.901 rs3813423 chr14:65347475 C/A cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC cis rs2721195 0.874 rs2721173 chr8:145744429 C/T cg11211951 chr8:145729740 GPT 0.43 7.63 0.42 4.3e-13 Age at first birth; CESC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg09323728 chr8:95962352 TP53INP1 -0.45 -9.86 -0.52 9.98e-20 Type 2 diabetes; CESC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg11859384 chr17:80120422 CCDC57 0.4 5.5 0.32 8.88e-8 Life satisfaction; CESC cis rs1062177 0.855 rs6884630 chr5:151268997 A/T cg12924095 chr5:151150029 G3BP1 0.41 5.53 0.32 7.54e-8 Preschool internalizing problems; CESC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg14664628 chr15:75095509 CSK -0.52 -6.85 -0.39 5.26e-11 Breast cancer; CESC cis rs10751667 0.643 rs7396046 chr11:937176 T/C cg06064525 chr11:970664 AP2A2 -0.5 -10.04 -0.52 2.7e-20 Alzheimer's disease (late onset); CESC cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg05347473 chr6:146136440 FBXO30 0.57 7.3 0.41 3.36e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.65 0.38 1.7e-10 Prudent dietary pattern; CESC cis rs16854884 0.632 rs34071449 chr3:143662861 C/T cg06585982 chr3:143692056 C3orf58 0.53 6.6 0.38 2.26e-10 Economic and political preferences (feminism/equality); CESC cis rs854765 0.583 rs6502622 chr17:17834691 A/G cg04398451 chr17:18023971 MYO15A -0.67 -9.75 -0.51 2.19e-19 Total body bone mineral density; CESC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg03806693 chr22:41940476 POLR3H -1.06 -12.46 -0.61 2.35e-28 Vitiligo; CESC cis rs1790761 0.667 rs598811 chr11:67311676 C/T cg24690094 chr11:67383802 NA 0.35 5.74 0.33 2.59e-8 Mean corpuscular volume; CESC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg15052019 chr19:19431593 KIAA0892;SF4 -0.41 -5.2 -0.3 3.93e-7 Tonsillectomy; CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.68 0.38 1.42e-10 Bipolar disorder; CESC cis rs10788264 0.569 rs3901289 chr10:124027433 T/C cg09507567 chr10:124027408 NA 0.43 6.64 0.38 1.75e-10 Total body bone mineral density; CESC cis rs9916302 0.904 rs55660616 chr17:37684990 C/A cg07936489 chr17:37558343 FBXL20 -0.8 -11.57 -0.58 2.46e-25 Glomerular filtration rate (creatinine); CESC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.74 -0.33 2.57e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs34779708 0.897 rs4934527 chr10:35281118 T/A cg04310649 chr10:35416472 CREM -0.52 -6.37 -0.36 8.48e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs977987 0.806 rs2903033 chr16:75389606 T/A cg03315344 chr16:75512273 CHST6 0.4 5.83 0.34 1.61e-8 Dupuytren's disease; CESC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.39 -5.12 -0.3 5.79e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7818345 1.000 rs6984145 chr8:19294111 A/G cg11303988 chr8:19266685 CSGALNACT1 0.35 6.32 0.36 1.12e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg21770322 chr7:97807741 LMTK2 0.55 8.08 0.44 2.32e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg17949981 chr6:28129498 ZNF389 0.48 6.14 0.35 3.05e-9 Depression; CESC cis rs67478160 0.634 rs941475 chr14:104240618 A/C cg01849466 chr14:104193079 ZFYVE21 -0.53 -7.8 -0.43 1.41e-13 Schizophrenia; CESC cis rs7208859 0.673 rs9891413 chr17:29208209 G/C cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs713587 0.571 rs2918630 chr2:25314186 A/G cg10045137 chr2:25383940 POMC -0.34 -5.08 -0.3 7.05e-7 Body mass index in non-asthmatics; CESC trans rs7615952 0.512 rs4646765 chr3:125820707 G/A cg07211511 chr3:129823064 LOC729375 -0.57 -6.28 -0.36 1.38e-9 Blood pressure (smoking interaction); CESC cis rs13191362 0.507 rs1954806 chr6:163051858 G/C cg06582575 chr6:163149167 PACRG;PARK2 -0.51 -6.09 -0.35 3.91e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04740264 chr16:3632588 BTBD12 -0.55 -6.28 -0.36 1.37e-9 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs763121 0.819 rs5757133 chr22:38947835 A/G cg06022373 chr22:39101656 GTPBP1 -0.79 -11.61 -0.58 1.83e-25 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24623068 chr5:154317667 GEMIN5 0.68 7.96 0.44 5e-14 Gut microbiome composition (summer); CESC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.87 0.34 1.27e-8 Electroencephalogram traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18247177 chr17:7745472 KDM6B 0.48 6.19 0.36 2.31e-9 Gut microbiota (bacterial taxa); CESC cis rs6912958 0.712 rs6454638 chr6:88329427 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.51 6.79 0.38 7.55e-11 Monocyte percentage of white cells; CESC cis rs1707322 1.000 rs4134387 chr1:46395158 A/T cg06784218 chr1:46089804 CCDC17 0.36 6.01 0.35 5.95e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9486719 0.948 rs6920913 chr6:96874297 A/G cg18709589 chr6:96969512 KIAA0776 0.49 5.55 0.32 6.82e-8 Migraine;Coronary artery disease; CESC cis rs36051895 0.664 rs12340866 chr9:5094185 G/A cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.61e-9 Pediatric autoimmune diseases; CESC cis rs67311347 1.000 rs1047855 chr3:40468896 A/G cg24209194 chr3:40518798 ZNF619 -0.54 -6.69 -0.38 1.3e-10 Renal cell carcinoma; CESC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg05564831 chr3:52568323 NT5DC2 -0.46 -7.14 -0.4 8.9e-12 Bipolar disorder; CESC cis rs7208859 0.673 rs999798 chr17:29158840 A/G cg19761014 chr17:28927070 LRRC37B2 0.59 6.03 0.35 5.62e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg26314531 chr2:26401878 FAM59B -0.78 -8.82 -0.48 1.6e-16 Gut microbiome composition (summer); CESC cis rs1580019 0.713 rs2122632 chr7:32524686 A/G cg06627557 chr7:32535165 LSM5;AVL9 -1.01 -16.42 -0.71 2.93e-42 Cognitive ability; CESC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg18876405 chr7:65276391 NA 0.53 7.27 0.41 4.11e-12 Aortic root size; CESC trans rs12310956 0.532 rs1525897 chr12:33941033 C/T cg26384229 chr12:38710491 ALG10B 0.57 7.99 0.44 4.13e-14 Morning vs. evening chronotype; CESC cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.17 0.6 2.3e-27 Colonoscopy-negative controls vs population controls; CESC cis rs7582180 0.700 rs1437971 chr2:100986964 A/C cg16145071 chr2:101727897 TBC1D8 -0.5 -5.31 -0.31 2.35e-7 Intelligence (multi-trait analysis); CESC cis rs7618501 1.000 rs11709680 chr3:49745188 C/T cg24308560 chr3:49941425 MST1R 0.51 6.95 0.39 2.87e-11 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10042178 chr1:87794589 LMO4 -0.45 -6.25 -0.36 1.66e-9 Gambling; CESC trans rs11992162 0.967 rs10112888 chr8:11830208 G/C cg15556689 chr8:8085844 FLJ10661 0.54 6.44 0.37 5.7e-10 Monocyte count; CESC cis rs244293 0.795 rs12940239 chr17:53068930 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.47 -6.14 -0.35 3.07e-9 Menarche (age at onset); CESC cis rs11166927 0.967 rs56343024 chr8:140803580 G/A cg16909799 chr8:140841666 TRAPPC9 0.62 8.98 0.48 5.1e-17 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.34 0.5 3.98e-18 Menopause (age at onset); CESC cis rs2645694 0.651 rs2703128 chr4:77819187 C/G cg18351406 chr4:77819688 ANKRD56 0.53 6.45 0.37 5.2e-10 Emphysema distribution in smoking; CESC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.11 19.58 0.77 2.06e-53 Height; CESC cis rs7927771 0.524 rs11039419 chr11:47851354 C/T cg18512352 chr11:47633146 NA 0.34 5.29 0.31 2.55e-7 Subjective well-being; CESC cis rs11031096 0.727 rs2268168 chr11:4142069 C/T cg18678763 chr11:4115507 RRM1 -0.46 -6.32 -0.36 1.12e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs2412208 0.509 rs7546792 chr1:7124346 C/T cg20434152 chr1:7120926 CAMTA1 -0.36 -5.81 -0.34 1.75e-8 Survival in sporadic amyotrophic lateral sclerosis; CESC cis rs793571 0.662 rs964285 chr15:59170964 A/G cg05156742 chr15:59063176 FAM63B -0.52 -6.95 -0.39 2.84e-11 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00995911 chr19:45004602 ZNF180 0.59 7.23 0.41 5.06e-12 Gut microbiome composition (summer); CESC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg26343298 chr8:95960752 TP53INP1 0.36 5.98 0.34 7.06e-9 Type 2 diabetes; CESC cis rs250677 1.000 rs40525 chr5:148432932 G/T cg18129178 chr5:148520854 ABLIM3 0.45 5.04 0.3 8.78e-7 Breast cancer; CESC cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg23978390 chr7:1156363 C7orf50 0.61 7.4 0.41 1.82e-12 Bronchopulmonary dysplasia; CESC cis rs3741151 1.000 rs60924672 chr11:73098724 A/C cg17517138 chr11:73019481 ARHGEF17 0.98 7.01 0.4 1.99e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs2406342 0.528 rs75536638 chr18:74499060 G/T cg16472389 chr18:74514291 NA 0.45 5.15 0.3 5.11e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); CESC cis rs4604732 0.574 rs111928142 chr1:247625229 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 7.52 0.42 8.51e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg12419862 chr22:24373484 LOC391322 -0.8 -11.73 -0.58 7.06e-26 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00356213 chr9:35103430 STOML2 -0.58 -6.81 -0.39 6.35e-11 Gut microbiome composition (summer); CESC cis rs9926296 0.632 rs2011925 chr16:89814064 T/G cg27121462 chr16:89883253 FANCA 0.58 7.01 0.4 1.98e-11 Vitiligo; CESC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg04414720 chr1:150670196 GOLPH3L 0.45 6.02 0.35 5.91e-9 Melanoma; CESC cis rs854765 0.619 rs4561528 chr17:17979099 C/T cg09796270 chr17:17721594 SREBF1 0.42 5.75 0.33 2.48e-8 Total body bone mineral density; CESC cis rs9469578 1.000 rs9469580 chr6:33715837 A/G cg18708504 chr6:33715942 IP6K3 -0.61 -7.43 -0.42 1.52e-12 Phosphorus levels; CESC cis rs3008870 1.000 rs3008888 chr1:67368965 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.02 14.11 0.65 4.39e-34 Lymphocyte percentage of white cells; CESC cis rs3091242 0.836 rs34997029 chr1:25783823 A/G cg27572855 chr1:25598939 RHD -0.46 -7.68 -0.43 3.17e-13 Erythrocyte sedimentation rate; CESC cis rs7551222 0.691 rs4951077 chr1:204482262 G/A cg20240347 chr1:204465584 NA -0.28 -5.65 -0.33 4.03e-8 Schizophrenia; CESC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg07701084 chr6:150067640 NUP43 0.39 5.16 0.3 4.78e-7 Lung cancer; CESC cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg10523679 chr1:76189770 ACADM 0.72 8.33 0.46 4.38e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11264213 0.901 rs645123 chr1:36458075 T/C cg27506609 chr1:36549197 TEKT2 0.49 5.15 0.3 5.03e-7 Schizophrenia; CESC cis rs12900413 0.603 rs11629982 chr15:90300272 G/A cg24249390 chr15:90295951 MESP1 -0.4 -5.38 -0.31 1.61e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.75e-12 Tonsillectomy; CESC cis rs6963495 0.932 rs55700120 chr7:105148460 G/T cg19920283 chr7:105172520 RINT1 0.66 6.28 0.36 1.36e-9 Bipolar disorder (body mass index interaction); CESC cis rs9486719 1.000 rs12208449 chr6:96903253 A/G cg18709589 chr6:96969512 KIAA0776 0.52 5.64 0.33 4.45e-8 Migraine;Coronary artery disease; CESC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg10295955 chr4:187884368 NA -1.01 -16.88 -0.72 6.4e-44 Lobe attachment (rater-scored or self-reported); CESC cis rs1879734 0.731 rs6691833 chr1:54159079 C/G cg23596471 chr1:54105337 GLIS1 0.35 5.67 0.33 3.77e-8 Mitral valve prolapse; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19886106 chr8:144776541 ZNF707 -0.53 -6.25 -0.36 1.66e-9 Gut microbiome composition (summer); CESC cis rs6963495 0.769 rs11556986 chr7:105177041 A/T cg13798780 chr7:105162888 PUS7 0.73 7.98 0.44 4.55e-14 Bipolar disorder (body mass index interaction); CESC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg13206674 chr6:150067644 NUP43 0.45 6.44 0.37 5.7e-10 Lung cancer; CESC cis rs193541 0.593 rs1035372 chr5:122169448 C/A cg19412675 chr5:122181750 SNX24 0.45 5.22 0.31 3.63e-7 Glucose homeostasis traits; CESC cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg24733560 chr20:60626293 TAF4 -0.45 -6.8 -0.39 6.95e-11 Body mass index; CESC cis rs9479482 0.967 rs763574 chr6:150349415 G/C cg03788504 chr6:150331562 NA -0.38 -7.1 -0.4 1.13e-11 Alopecia areata; CESC cis rs35110281 0.837 rs2838340 chr21:45076373 A/G cg04455712 chr21:45112962 RRP1B 0.39 6.09 0.35 3.85e-9 Mean corpuscular volume; CESC cis rs62244186 0.520 rs2372828 chr3:44784949 A/G cg15225532 chr3:44803084 KIF15;KIAA1143 -0.49 -6.47 -0.37 4.72e-10 Depressive symptoms; CESC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.89 0.52 7.86e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg19482086 chr6:160211437 TCP1;MRPL18 -0.69 -8.96 -0.48 5.78e-17 Age-related macular degeneration (geographic atrophy); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21511036 chr2:227663538 IRS1 0.45 6.13 0.35 3.23e-9 Gut microbiota (bacterial taxa); CESC cis rs17818399 0.653 rs34050156 chr2:46777646 A/G cg02822958 chr2:46747628 ATP6V1E2 0.48 5.83 0.34 1.65e-8 Height; CESC cis rs9911578 1.000 rs2611782 chr17:56717956 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16349277 chr4:83323642 NA -0.47 -6.56 -0.37 2.83e-10 Gut microbiota (bacterial taxa); CESC cis rs7149337 0.836 rs12588488 chr14:51660217 C/A cg23942311 chr14:51606299 NA 0.45 7.8 0.43 1.45e-13 Cancer; CESC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.13 -0.35 3.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg07936489 chr17:37558343 FBXL20 0.75 10.64 0.55 2.9e-22 Glomerular filtration rate (creatinine); CESC cis rs7582720 0.945 rs2351524 chr2:203880992 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 -0.78 -7.13 -0.4 9.69e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg24733560 chr20:60626293 TAF4 0.47 6.72 0.38 1.09e-10 Body mass index; CESC trans rs7618501 0.603 rs72942333 chr3:49986118 T/C cg21659725 chr3:3221576 CRBN 0.55 7.6 0.42 5.29e-13 Intelligence (multi-trait analysis); CESC trans rs3780486 0.846 rs10971419 chr9:33124161 T/C cg20290983 chr6:43655470 MRPS18A 0.99 18.4 0.75 2.85e-49 IgG glycosylation; CESC cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.51 -5.91 -0.34 1.02e-8 Osteoporosis; CESC cis rs4523957 0.583 rs1565763 chr17:2055300 T/C cg16513277 chr17:2031491 SMG6 -0.76 -11.02 -0.56 1.68e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs854765 0.551 rs8070748 chr17:17859421 A/G cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14607407 chr21:34638535 IL10RB -0.59 -6.54 -0.37 3.06e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.512 rs7291736 chr22:42124874 C/A cg03806693 chr22:41940476 POLR3H 1.14 13.61 0.64 2.45e-32 Vitiligo; CESC cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs910316 1.000 rs12889309 chr14:75593902 C/T cg16144293 chr14:75469539 EIF2B2 -0.39 -5.08 -0.3 7.04e-7 Height; CESC cis rs7605827 0.930 rs11684395 chr2:15530870 A/G cg19274914 chr2:15703543 NA 0.35 6.2 0.36 2.12e-9 Educational attainment (years of education); CESC cis rs4727027 1.000 rs4727027 chr7:148869277 C/T cg23583168 chr7:148888333 NA -0.8 -12.42 -0.61 3.23e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2109514 0.650 rs12531767 chr7:116129005 T/A cg12739419 chr7:116140593 CAV2 -0.38 -6.77 -0.38 8.45e-11 Prevalent atrial fibrillation; CESC trans rs3780486 0.846 rs10813948 chr9:33121570 G/A cg20290983 chr6:43655470 MRPS18A 0.98 18.13 0.74 2.59e-48 IgG glycosylation; CESC cis rs6570726 0.935 rs382910 chr6:145865941 G/A cg05347473 chr6:146136440 FBXO30 0.46 6.16 0.35 2.72e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs7927771 0.524 rs7943464 chr11:47886639 T/A cg18512352 chr11:47633146 NA 0.35 5.43 0.32 1.29e-7 Subjective well-being; CESC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg11890956 chr21:40555474 PSMG1 0.96 15.73 0.69 7.86e-40 Cognitive function; CESC cis rs6429082 0.967 rs704710 chr1:235621026 A/G cg26050004 chr1:235667680 B3GALNT2 0.47 6.34 0.36 1e-9 Adiposity; CESC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.37 -0.5 3.42e-18 Alzheimer's disease; CESC cis rs72945132 0.882 rs7932431 chr11:70166059 A/T cg00319359 chr11:70116639 PPFIA1 0.78 7.75 0.43 1.98e-13 Coronary artery disease; CESC cis rs2075371 0.835 rs1646724 chr7:134001875 T/G cg20476274 chr7:133979776 SLC35B4 0.64 9.07 0.49 2.71e-17 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25372841 chr8:145675454 CYHR1 0.48 6.84 0.39 5.61e-11 Fibrinogen levels; CESC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg26343298 chr8:95960752 TP53INP1 0.36 5.95 0.34 8.49e-9 Type 2 diabetes; CESC trans rs6951245 0.554 rs76243429 chr7:1152543 C/T cg13565492 chr6:43139072 SRF -0.74 -8.72 -0.47 3.11e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs57143961 1 rs57143961 chr19:16533225 C/CT cg10248733 chr19:16607483 C19orf44;CALR3 -0.62 -6.65 -0.38 1.64e-10 Lymphocyte percentage of white cells; CESC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg11366901 chr6:160182831 ACAT2 0.82 10.5 0.54 8.86e-22 Age-related macular degeneration (geographic atrophy); CESC cis rs9549260 0.683 rs35594717 chr13:41240783 G/A cg21288729 chr13:41239152 FOXO1 0.57 5.55 0.32 7.09e-8 Red blood cell count; CESC cis rs425277 0.583 rs925905 chr1:2044037 T/C cg16545954 chr1:2118288 C1orf86 -0.32 -6.08 -0.35 4.14e-9 Height; CESC cis rs4909189 0.915 rs11773551 chr7:158136146 C/T cg06219351 chr7:158114137 PTPRN2 -0.58 -7.18 -0.4 6.86e-12 Response to amphetamines; CESC trans rs7618501 0.635 rs34080578 chr3:50026029 A/C cg21659725 chr3:3221576 CRBN 0.53 7.37 0.41 2.19e-12 Intelligence (multi-trait analysis); CESC cis rs3762637 1.000 rs7617042 chr3:122190985 C/T cg24169773 chr3:122142474 KPNA1 -0.54 -6.33 -0.36 1.04e-9 LDL cholesterol levels; CESC cis rs11785400 0.793 rs7459963 chr8:143737129 C/T cg24634471 chr8:143751801 JRK 0.46 5.94 0.34 9.01e-9 Schizophrenia; CESC cis rs17376456 0.504 rs7702649 chr5:93065149 C/A cg25358565 chr5:93447407 FAM172A 0.67 7.24 0.41 4.89e-12 Diabetic retinopathy; CESC cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.22e-15 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg22823121 chr1:150693482 HORMAD1 0.36 5.04 0.3 8.54e-7 Melanoma; CESC cis rs7727544 0.709 rs272852 chr5:131688767 G/A cg07395648 chr5:131743802 NA -0.4 -5.3 -0.31 2.48e-7 Blood metabolite levels; CESC cis rs826838 0.967 rs12823908 chr12:38845686 T/C cg13010199 chr12:38710504 ALG10B 0.6 8.53 0.46 1.18e-15 Heart rate; CESC cis rs6088590 0.561 rs6087600 chr20:33157217 T/C cg24642439 chr20:33292090 TP53INP2 0.62 8.42 0.46 2.42e-15 Coronary artery disease; CESC trans rs875971 1.000 rs778726 chr7:65828731 C/T cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.66e-9 Aortic root size; CESC cis rs4423214 0.802 rs2276358 chr11:71184498 G/A cg05163923 chr11:71159392 DHCR7 -0.68 -7.76 -0.43 1.82e-13 Vitamin D levels; CESC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg16405210 chr4:1374714 KIAA1530 -0.7 -9.68 -0.51 3.46e-19 Longevity; CESC trans rs561341 0.825 rs2008368 chr17:30347397 T/C cg20587970 chr11:113659929 NA -1.47 -18.13 -0.74 2.44e-48 Hip circumference adjusted for BMI; CESC cis rs3091242 0.933 rs7541095 chr1:25761291 T/C cg27572855 chr1:25598939 RHD 0.43 7.2 0.4 6.13e-12 Erythrocyte sedimentation rate; CESC cis rs2929278 0.617 rs11070410 chr15:44057045 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -7.54 -0.42 7.29e-13 Schizophrenia; CESC cis rs7918232 0.505 rs788221 chr10:27442247 G/C cg14442939 chr10:27389572 ANKRD26 -0.66 -5.03 -0.3 8.92e-7 Breast cancer; CESC cis rs7949030 0.588 rs2509982 chr11:62312318 C/T cg02375832 chr11:62437615 C11orf48 -0.36 -5.27 -0.31 2.83e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs12477438 0.666 rs10179910 chr2:99658503 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.57 -7.83 -0.43 1.19e-13 Chronic sinus infection; CESC cis rs4722166 0.598 rs4722178 chr7:22798650 T/C cg05472934 chr7:22766657 IL6 0.43 5.79 0.34 1.97e-8 Lung cancer; CESC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg24675658 chr1:53192096 ZYG11B 0.57 7.82 0.43 1.23e-13 Monocyte count; CESC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11792861 0.851 rs4542004 chr9:111814478 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.5 6.75 0.38 9.43e-11 Menarche (age at onset); CESC cis rs7843479 0.601 rs11781959 chr8:21841863 C/G cg17168535 chr8:21777572 XPO7 0.73 11.87 0.59 2.35e-26 Mean corpuscular volume; CESC cis rs12368653 0.840 rs10877020 chr12:58188014 G/A cg00677455 chr12:58241039 CTDSP2 -0.47 -6.16 -0.35 2.67e-9 Multiple sclerosis; CESC cis rs17253792 0.822 rs17746033 chr14:56061837 G/A cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC cis rs1322639 0.614 rs6925950 chr6:169563958 A/G cg03254818 chr6:169586852 NA 0.48 5.22 0.31 3.57e-7 Pulse pressure; CESC cis rs2228479 0.681 rs3212346 chr16:89982358 G/A cg00800038 chr16:89945340 TCF25 -0.63 -6.6 -0.38 2.19e-10 Skin colour saturation; CESC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC cis rs2439831 0.867 rs2447196 chr15:43893818 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.82 -8.56 -0.47 9.6e-16 Lung cancer in ever smokers; CESC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg23172400 chr8:95962367 TP53INP1 -0.44 -9.16 -0.49 1.49e-17 Type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09302448 chr16:67562672 FAM65A 0.51 7.04 0.4 1.6e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg10556349 chr10:835070 NA 0.76 6.39 0.37 7.22e-10 Eosinophil percentage of granulocytes; CESC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg13647721 chr17:30228624 UTP6 0.59 5.28 0.31 2.69e-7 Hip circumference adjusted for BMI; CESC cis rs2243480 1.000 rs10807702 chr7:65767843 C/T cg12463550 chr7:65579703 CRCP 0.77 5.93 0.34 9.18e-9 Diabetic kidney disease; CESC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg11987759 chr7:65425863 GUSB -0.48 -6.62 -0.38 1.93e-10 Aortic root size; CESC cis rs787274 1.000 rs1711739 chr9:115464474 G/A cg13803584 chr9:115635662 SNX30 0.52 5.14 0.3 5.29e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg00933542 chr6:150070202 PCMT1 0.31 5.42 0.32 1.33e-7 Lung cancer; CESC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg05564831 chr3:52568323 NT5DC2 0.45 6.78 0.38 7.87e-11 Bipolar disorder; CESC cis rs2180341 0.814 rs6940933 chr6:127732740 C/G cg27446573 chr6:127587934 RNF146 0.83 11.83 0.59 3.26e-26 Breast cancer; CESC cis rs2243480 1.000 rs34192067 chr7:65887657 C/A cg13147721 chr7:65941812 NA -0.95 -8.95 -0.48 6.27e-17 Diabetic kidney disease; CESC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg05564831 chr3:52568323 NT5DC2 0.47 7.33 0.41 2.81e-12 Electroencephalogram traits; CESC cis rs7772486 0.686 rs6570701 chr6:145954090 A/G cg23711669 chr6:146136114 FBXO30 0.91 13.45 0.64 8.62e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs1620921 0.505 rs1549741 chr6:161204783 G/T cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs10779751 0.960 rs2076657 chr1:11318763 C/G cg08854313 chr1:11322531 MTOR 0.91 14.45 0.66 2.77e-35 Body mass index; CESC cis rs9549367 0.601 rs558869 chr13:113849932 G/T cg00898013 chr13:113819073 PROZ 0.45 6.84 0.39 5.48e-11 Platelet distribution width; CESC cis rs9325144 0.505 rs6582691 chr12:38806894 T/C cg26384229 chr12:38710491 ALG10B -0.67 -11.36 -0.57 1.23e-24 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.51 0.42 9.06e-13 Prudent dietary pattern; CESC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg23034840 chr1:205782522 SLC41A1 0.66 7.89 0.44 8.02e-14 Menarche (age at onset); CESC cis rs11077773 1.000 rs11077773 chr17:73060073 C/T cg27626185 chr17:73056755 KCTD2 0.57 6.0 0.35 6.39e-9 Information processing speed; CESC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg13770153 chr20:60521292 NA -0.44 -5.7 -0.33 3.2e-8 Body mass index; CESC cis rs10089 1.000 rs3805606 chr5:127470813 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.74 -9.78 -0.51 1.74e-19 Ileal carcinoids; CESC cis rs7903847 0.642 rs3814553 chr10:99155984 G/A cg20016023 chr10:99160130 RRP12 -0.3 -5.16 -0.3 4.77e-7 Granulocyte percentage of myeloid white cells; CESC cis rs56399783 0.803 rs17132665 chr7:2802173 T/C cg19731401 chr7:2775893 GNA12 0.63 5.59 0.33 5.51e-8 Childhood ear infection; CESC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg04369109 chr6:150039330 LATS1 -0.41 -5.81 -0.34 1.82e-8 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04486506 chr20:62577863 UCKL1 0.45 6.46 0.37 5.05e-10 Fibrinogen levels; CESC cis rs13315871 0.929 rs13082278 chr3:58318224 A/G cg20936604 chr3:58311152 NA -0.51 -5.13 -0.3 5.57e-7 Cholesterol, total; CESC cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7116495 0.529 rs575871 chr11:71778822 A/G cg26138937 chr11:71823887 C11orf51 -0.92 -6.95 -0.39 2.9100000000000002e-11 Severe influenza A (H1N1) infection; CESC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg19680485 chr15:31195859 MTMR15 0.5 6.05 0.35 4.83e-9 Huntington's disease progression; CESC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.03 -0.49 3.55e-17 Developmental language disorder (linguistic errors); CESC cis rs2086824 0.702 rs3114896 chr16:89393562 C/T cg08822215 chr16:89438651 ANKRD11 0.39 5.51 0.32 8.31e-8 Multiple myeloma (IgH translocation); CESC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg00612595 chr21:47717864 NA -0.37 -5.21 -0.3 3.81e-7 Testicular germ cell tumor; CESC cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg04166393 chr7:2884313 GNA12 0.39 5.14 0.3 5.3e-7 Height; CESC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg19163074 chr7:65112434 INTS4L2 -0.46 -5.05 -0.3 8.17e-7 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19313758 chr11:64889193 FAU;MRPL49 0.49 6.42 0.37 6.34e-10 Gut microbiota (bacterial taxa); CESC cis rs3820928 0.874 rs6717168 chr2:227901342 C/T cg11843606 chr2:227700838 RHBDD1 -0.46 -6.12 -0.35 3.36e-9 Pulmonary function; CESC cis rs11792861 0.926 rs72607163 chr9:111803128 G/T cg14384093 chr9:111878565 C9orf5 -0.41 -5.12 -0.3 5.85e-7 Menarche (age at onset); CESC cis rs1545257 0.537 rs4581852 chr2:24638256 C/A cg06627628 chr2:24431161 ITSN2 -0.48 -5.88 -0.34 1.21e-8 Sjögren's syndrome; CESC cis rs713587 0.776 rs3731623 chr2:25163783 T/C cg01884057 chr2:25150051 NA 0.39 7.38 0.41 1.99e-12 Body mass index in non-asthmatics; CESC cis rs11711311 0.868 rs13091621 chr3:113481977 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.59 7.77 0.43 1.71e-13 IgG glycosylation; CESC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg21770322 chr7:97807741 LMTK2 0.56 8.63 0.47 5.86e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs10870270 0.957 rs7074604 chr10:133740373 G/C cg17892150 chr10:133769511 PPP2R2D -0.86 -12.69 -0.61 3.83e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs835154 0.900 rs835153 chr5:14877474 A/G cg18064842 chr5:14874549 NA -0.34 -5.21 -0.31 3.71e-7 Blood metabolite levels; CESC cis rs672059 1.000 rs483783 chr1:183162152 G/T ch.1.3577855R chr1:183094577 LAMC1 0.55 7.22 0.41 5.37e-12 Hypertriglyceridemia; CESC cis rs7666738 0.830 rs35644814 chr4:98886111 G/C cg17366294 chr4:99064904 C4orf37 0.55 7.65 0.43 3.72e-13 Colonoscopy-negative controls vs population controls; CESC trans rs561341 1.000 rs560132 chr17:30320019 C/T cg27661571 chr11:113659931 NA -0.87 -8.01 -0.44 3.71e-14 Hip circumference adjusted for BMI; CESC cis rs6032067 0.929 rs45461302 chr20:43805274 G/A cg10761708 chr20:43804764 PI3 0.53 6.33 0.36 1.04e-9 Blood protein levels; CESC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg27572855 chr1:25598939 RHD 0.44 7.23 0.41 5.28e-12 Erythrocyte sedimentation rate; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06745235 chr1:180471494 ACBD6 0.48 6.73 0.38 1.06e-10 Systemic lupus erythematosus; CESC cis rs3806843 0.966 rs4141841 chr5:140203432 C/T cg26395211 chr5:140044315 WDR55 -0.44 -5.49 -0.32 9.2e-8 Depressive symptoms (multi-trait analysis); CESC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.32 -0.31 2.17e-7 Total body bone mineral density; CESC cis rs703842 1.000 rs703842 chr12:58162739 C/T cg00599273 chr12:58146742 CDK4 -0.33 -5.05 -0.3 8.12e-7 Multiple sclerosis; CESC cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -7.6 -0.42 5.23e-13 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21652505 chr19:40023540 EID2B 0.57 6.64 0.38 1.77e-10 Gut microbiome composition (summer); CESC cis rs72945132 0.882 rs58039907 chr11:70183336 C/T cg00319359 chr11:70116639 PPFIA1 0.72 6.97 0.39 2.51e-11 Coronary artery disease; CESC cis rs1153858 0.943 rs11070454 chr15:45680252 C/T cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs3859192 0.577 rs25645 chr17:38173143 G/A cg17467752 chr17:38218738 THRA -0.45 -5.94 -0.34 8.9e-9 White blood cell count; CESC cis rs6547741 1.000 rs6749052 chr2:27772879 A/T cg21248554 chr2:27665150 KRTCAP3 0.25 5.24 0.31 3.28e-7 Oral cavity cancer; CESC cis rs9987353 0.566 rs34389718 chr8:9065525 A/G cg15556689 chr8:8085844 FLJ10661 -0.53 -6.19 -0.36 2.22e-9 Recombination measurement; CESC cis rs5758511 0.514 rs5751240 chr22:42595258 G/C cg00645731 chr22:42541494 CYP2D7P1 0.59 8.88 0.48 1.02e-16 Birth weight; CESC cis rs9287719 0.967 rs6719701 chr2:10748283 G/A cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs4423214 0.959 rs12800438 chr11:71171003 G/A cg05163923 chr11:71159392 DHCR7 0.83 11.29 0.57 2.17e-24 Vitamin D levels; CESC cis rs7267979 1.000 rs6050542 chr20:25318879 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -18.7 -0.75 2.52e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg22143856 chr6:28129313 ZNF389 0.51 6.55 0.37 3e-10 Depression; CESC trans rs9325144 0.600 rs61931871 chr12:38829889 G/A cg23762105 chr12:34175262 ALG10 0.47 6.09 0.35 3.93e-9 Morning vs. evening chronotype; CESC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg20295408 chr7:1910781 MAD1L1 -0.4 -5.03 -0.3 9.13e-7 Bipolar disorder and schizophrenia; CESC cis rs12142240 0.698 rs6683192 chr1:46830257 C/T cg10495392 chr1:46806563 NSUN4 0.58 6.3 0.36 1.24e-9 Menopause (age at onset); CESC cis rs1559088 1.000 rs7245404 chr19:33550589 C/T cg27124370 chr19:33622961 WDR88 0.42 5.34 0.31 1.99e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09279412 chr7:101459283 CUX1 0.56 6.55 0.37 2.96e-10 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg17372223 chr3:52568218 NT5DC2 0.42 6.29 0.36 1.32e-9 Bipolar disorder; CESC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg16680214 chr1:154839983 KCNN3 -0.5 -7.67 -0.43 3.27e-13 Prostate cancer; CESC cis rs7560272 0.695 rs10190002 chr2:73794054 C/T cg20560298 chr2:73613845 ALMS1 -0.5 -7.17 -0.4 7.49e-12 Schizophrenia; CESC cis rs7402982 0.934 rs8028620 chr15:99202875 C/T cg03437748 chr15:99193247 IGF1R 0.73 11.64 0.58 1.49e-25 Birth weight; CESC cis rs17253792 0.822 rs7145064 chr14:56088860 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.03 0.3 9.02e-7 Putamen volume; CESC cis rs7824557 0.628 rs11994376 chr8:11202960 G/A cg21775007 chr8:11205619 TDH 0.58 8.89 0.48 9.39e-17 Retinal vascular caliber; CESC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.18e-7 Aortic root size; CESC cis rs7647973 1.000 rs3866330 chr3:49582994 T/C cg06212747 chr3:49208901 KLHDC8B 0.6 8.13 0.45 1.66e-14 Menarche (age at onset); CESC cis rs7555523 0.887 rs4657477 chr1:165736175 C/T cg24409356 chr1:165738333 TMCO1 1.01 8.98 0.48 5.17e-17 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.55 -0.42 6.87e-13 Alzheimer's disease; CESC cis rs7621025 0.542 rs71336078 chr3:136489602 G/A cg15507776 chr3:136538369 TMEM22 -0.77 -7.16 -0.4 8.06e-12 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs2795502 1.000 rs2744092 chr10:43339343 T/C cg20628663 chr10:43360327 NA -0.63 -7.47 -0.42 1.16e-12 Blood protein levels; CESC cis rs148734725 1 rs148734725 chr3:49406708 G/A cg03060546 chr3:49711283 APEH -0.54 -6.1 -0.35 3.73e-9 Educational attainment (college completion); CESC cis rs9399401 0.667 rs12213892 chr6:142702234 A/G cg03128060 chr6:142623767 GPR126 0.37 6.5 0.37 4e-10 Chronic obstructive pulmonary disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11315179 chr8:103876601 AZIN1 0.57 6.35 0.36 9.23e-10 Gut microbiome composition (summer); CESC cis rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06181531 chr16:57023355 NLRC5 0.34 5.15 0.3 5.14e-7 Gambling; CESC cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg18016565 chr1:150552671 MCL1 -0.43 -7.2 -0.4 6.08e-12 Tonsillectomy; CESC cis rs854765 0.693 rs12936037 chr17:17777245 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.5 -6.96 -0.39 2.63e-11 Total body bone mineral density; CESC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg18479299 chr3:125709523 NA -0.48 -5.24 -0.31 3.29e-7 Blood pressure (smoking interaction); CESC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.17e-12 Tonsillectomy; CESC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg08219700 chr8:58056026 NA 0.41 5.38 0.31 1.62e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20526205 chr7:96339258 SHFM1 0.58 6.51 0.37 3.7e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs1813251 chr4:98921170 A/G cg17366294 chr4:99064904 C4orf37 0.57 7.89 0.44 8.07e-14 Colonoscopy-negative controls vs population controls; CESC cis rs7091068 0.616 rs4322326 chr10:95483382 A/T cg20715218 chr10:95462985 C10orf4 0.49 5.04 0.3 8.66e-7 Urinary tract infection frequency; CESC cis rs11677416 1.000 rs1800587 chr2:113542960 C/T cg27083787 chr2:113543245 IL1A 0.41 5.23 0.31 3.53e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs6728642 1.000 rs113934577 chr2:97888047 G/A cg26665480 chr2:98280029 ACTR1B -0.92 -6.97 -0.39 2.47e-11 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs9913156 0.793 rs8074545 chr17:4567337 C/G cg00122941 chr17:4613640 ARRB2 -0.82 -9.66 -0.51 4.06e-19 Lymphocyte counts; CESC cis rs3087591 1.000 rs7216033 chr17:29574642 A/G cg24425628 chr17:29625626 OMG;NF1 -0.46 -5.82 -0.34 1.69e-8 Hip circumference; CESC cis rs8180040 0.726 rs4078466 chr3:47126543 C/T cg27129171 chr3:47204927 SETD2 0.72 11.05 0.56 1.37e-23 Colorectal cancer; CESC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg13012494 chr21:47604986 C21orf56 0.48 6.29 0.36 1.32e-9 Testicular germ cell tumor; CESC cis rs9902453 0.845 rs7209622 chr17:28256807 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.2 0.53 7.85e-21 Coffee consumption (cups per day); CESC cis rs6540559 0.673 rs17015309 chr1:210007218 C/T cg21951975 chr1:209979733 IRF6 0.58 6.68 0.38 1.39e-10 Cleft lip with or without cleft palate; CESC cis rs4700695 0.719 rs1643415 chr5:65447087 T/C cg21114390 chr5:65439923 SFRS12 -0.49 -6.04 -0.35 5.09e-9 Facial morphology (factor 19); CESC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs798554 0.591 rs1713913 chr7:2895627 C/T cg18446336 chr7:2847575 GNA12 -0.31 -5.05 -0.3 8.06e-7 Height; CESC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg21092303 chr7:65958667 NA -0.4 -5.21 -0.3 3.81e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19594360 chr1:151255303 ZNF687 0.56 6.57 0.37 2.73e-10 Gut microbiome composition (summer); CESC cis rs2109514 0.902 rs7810505 chr7:116111078 G/T cg12739419 chr7:116140593 CAV2 -0.38 -6.83 -0.39 5.8200000000000003e-11 Prevalent atrial fibrillation; CESC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg09359103 chr1:154839909 KCNN3 -0.65 -12.24 -0.6 1.38e-27 Prostate cancer; CESC cis rs2760061 0.626 rs592736 chr1:228116831 A/G cg02753203 chr1:228287806 NA -0.51 -7.71 -0.43 2.57e-13 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25277630 chr1:53662708 CPT2 -0.53 -6.15 -0.35 2.82e-9 Gut microbiome composition (summer); CESC cis rs7044106 0.718 rs1981021 chr9:123388393 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.8 12.55 0.61 1.17e-28 Hip circumference adjusted for BMI; CESC cis rs9611565 0.592 rs5996038 chr22:41965300 T/C cg06634786 chr22:41940651 POLR3H -0.62 -6.75 -0.38 9.16e-11 Vitiligo; CESC cis rs7714584 0.793 rs12653039 chr5:150252631 G/A cg22134413 chr5:150180641 NA 0.63 6.38 0.36 7.8e-10 Crohn's disease; CESC cis rs9926296 0.632 rs7184315 chr16:89799373 C/G cg03388025 chr16:89894329 SPIRE2 -0.3 -5.17 -0.3 4.55e-7 Vitiligo; CESC cis rs10883723 0.810 rs1056857 chr10:104240003 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.75 -0.33 2.48e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg00310523 chr12:86230176 RASSF9 0.42 6.35 0.36 9.52e-10 Major depressive disorder; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg02748427 chr1:92764574 RPAP2;GLMN -0.49 -6.59 -0.38 2.34e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6912958 0.712 rs6908386 chr6:88354746 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.22 -0.31 3.56e-7 Monocyte percentage of white cells; CESC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg00310523 chr12:86230176 RASSF9 0.35 5.38 0.31 1.67e-7 Major depressive disorder; CESC cis rs1538970 0.924 rs11211118 chr1:45930270 A/C cg06784218 chr1:46089804 CCDC17 0.34 5.45 0.32 1.14e-7 Platelet count; CESC cis rs1018836 0.886 rs4734246 chr8:91569028 A/C cg16814680 chr8:91681699 NA -0.72 -10.29 -0.53 4.01e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2204008 0.604 rs2320521 chr12:38253789 A/G cg13010199 chr12:38710504 ALG10B 0.48 6.04 0.35 5.23e-9 Bladder cancer; CESC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 1.000 rs1472288 chr17:56910720 G/A cg12560992 chr17:57184187 TRIM37 0.94 15.75 0.7 6.57e-40 Intelligence (multi-trait analysis); CESC cis rs11785693 0.865 rs7815144 chr8:4970788 G/T cg26367366 chr8:4980734 NA -0.68 -6.47 -0.37 4.62e-10 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs2243480 1.000 rs160652 chr7:65538431 A/G cg18252515 chr7:66147081 NA -1.37 -13.35 -0.63 1.91e-31 Diabetic kidney disease; CESC cis rs10129255 0.646 rs55995061 chr14:107207547 A/G cg23076370 chr14:107095027 NA -0.62 -8.49 -0.46 1.45e-15 Kawasaki disease; CESC cis rs763014 0.931 rs7199839 chr16:636126 T/C cg07343612 chr16:622815 PIGQ -0.55 -7.99 -0.44 4.25e-14 Height; CESC cis rs4604732 0.536 rs12037221 chr1:247631212 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 5.96 0.34 7.9e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2777491 1.000 rs11631770 chr15:41737059 T/C cg18705301 chr15:41695430 NDUFAF1 -0.64 -9.62 -0.51 5.41e-19 Ulcerative colitis; CESC cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg09997546 chr11:8931473 C11orf17;ST5 0.32 5.29 0.31 2.58e-7 Hemoglobin concentration; CESC cis rs6546550 0.933 rs6546555 chr2:70135760 A/G cg02498382 chr2:70120550 SNRNP27 -0.39 -6.82 -0.39 5.98e-11 Prevalent atrial fibrillation; CESC cis rs4243830 0.850 rs1064835 chr1:6585539 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.65 6.57 0.37 2.68e-10 Body mass index; CESC trans rs208520 0.661 rs704519 chr6:66801136 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.8 -0.62 1.63e-29 Exhaled nitric oxide output; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01830674 chr2:219433148 RQCD1;USP37 0.48 6.49 0.37 4.12e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6963495 0.818 rs56268110 chr7:105166712 T/C cg02135003 chr7:105160482 PUS7 -0.46 -5.51 -0.32 8.38e-8 Bipolar disorder (body mass index interaction); CESC cis rs3008870 0.755 rs2815374 chr1:67507387 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.65 8.39 0.46 2.95e-15 Lymphocyte percentage of white cells; CESC cis rs2070488 1.000 rs2268757 chr3:38505853 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.94 17.63 0.73 1.48e-46 Electrocardiographic conduction measures; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16902244 chr1:24117464 LYPLA2 0.45 6.47 0.37 4.81e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs281302 0.621 rs421853 chr15:47744331 C/T cg15377044 chr10:47688638 ANTXRL -0.43 -6.2 -0.36 2.1e-9 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14112570 chr9:131644312 CCBL1;LRRC8A -0.44 -6.14 -0.35 3.03e-9 Fibrinogen levels; CESC cis rs5758659 0.652 rs1063392 chr22:42454950 C/T cg19513890 chr22:42538836 CYP2D7P1 0.39 5.92 0.34 9.92e-9 Cognitive function; CESC cis rs933688 1.000 rs332544 chr5:90778848 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.94 11.49 0.58 4.76e-25 Smoking behavior; CESC cis rs684232 0.644 rs2657613 chr17:623902 T/C cg15660573 chr17:549704 VPS53 -0.65 -8.83 -0.48 1.47e-16 Prostate cancer; CESC cis rs9039 1.000 rs17567434 chr16:9221447 C/G cg08831531 chr16:9218945 NA -0.53 -7.02 -0.4 1.87e-11 Menopause (age at onset); CESC cis rs9549367 0.826 rs9549713 chr13:113905308 G/T cg00898013 chr13:113819073 PROZ -0.53 -7.21 -0.41 5.74e-12 Platelet distribution width; CESC cis rs644799 0.710 rs11021309 chr11:95501898 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.77 11.59 0.58 2.21e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4900538 0.855 rs1190537 chr14:102887816 C/T cg18135206 chr14:102964638 TECPR2 -0.75 -9.5 -0.5 1.29e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg06212747 chr3:49208901 KLHDC8B 0.7 9.05 0.49 3.26e-17 Parkinson's disease; CESC cis rs4253772 0.701 rs9627280 chr22:46643964 T/C cg09491104 chr22:46646882 C22orf40 -0.56 -8.71 -0.47 3.38e-16 LDL cholesterol;Cholesterol, total; CESC cis rs10465746 0.570 rs11163887 chr1:84474718 C/T cg10977910 chr1:84465055 TTLL7 0.43 5.46 0.32 1.12e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06362048 chr16:15051589 NA -0.61 -7.04 -0.4 1.6e-11 Gut microbiome composition (summer); CESC cis rs9905704 0.560 rs2450509 chr17:56446150 T/C cg12560992 chr17:57184187 TRIM37 0.64 5.49 0.32 9.54e-8 Testicular germ cell tumor; CESC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg15782153 chr7:917662 C7orf20 0.46 6.63 0.38 1.89e-10 Perceived unattractiveness to mosquitoes; CESC cis rs7660520 0.524 rs4862100 chr4:183732709 G/T cg04526738 chr4:183727387 NA 0.7 6.47 0.37 4.61e-10 Pediatric autoimmune diseases; CESC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg13206674 chr6:150067644 NUP43 0.43 5.98 0.34 7.33e-9 Lung cancer; CESC cis rs1847505 0.716 rs7321236 chr13:61516730 C/T cg14094164 chr13:61491000 NA 0.36 5.33 0.31 2.06e-7 Polychlorinated biphenyl levels; CESC cis rs35123781 0.654 rs356443 chr5:139077829 G/C cg10513866 chr5:139070639 NA 0.42 5.83 0.34 1.6e-8 Schizophrenia; CESC cis rs1665050 0.534 rs4600408 chr15:59246800 T/C cg05156742 chr15:59063176 FAM63B 0.49 6.15 0.35 2.92e-9 Atopic dermatitis; CESC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg07677032 chr17:61819896 STRADA 0.42 5.41 0.32 1.44e-7 Height; CESC cis rs2180341 0.842 rs7739679 chr6:127545428 G/A cg27446573 chr6:127587934 RNF146 0.96 11.83 0.59 3.2e-26 Breast cancer; CESC cis rs7301826 0.610 rs7961690 chr12:131296880 G/T cg11011512 chr12:131303247 STX2 -0.45 -5.49 -0.32 9.37e-8 Plasma plasminogen activator levels; CESC cis rs6546550 0.901 rs7419837 chr2:70146625 T/C cg02498382 chr2:70120550 SNRNP27 -0.41 -7.26 -0.41 4.34e-12 Prevalent atrial fibrillation; CESC cis rs17001868 0.568 rs9611325 chr22:40782490 G/A cg07138101 chr22:40742427 ADSL 0.59 5.78 0.33 2.09e-8 Mammographic density (dense area); CESC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg24675658 chr1:53192096 ZYG11B -0.56 -6.98 -0.39 2.36e-11 Monocyte count; CESC cis rs1580019 0.665 rs34147895 chr7:32531796 G/C cg06627557 chr7:32535165 LSM5;AVL9 1.02 16.48 0.71 1.73e-42 Cognitive ability; CESC cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg14393609 chr7:65229607 NA -0.4 -5.2 -0.3 3.97e-7 Aortic root size; CESC cis rs2749592 0.550 rs9733309 chr10:37882405 G/A cg00409905 chr10:38381863 ZNF37A 0.43 5.79 0.33 2.02e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg27028030 chr7:100209634 MOSPD3 0.57 5.58 0.32 6.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1348850 0.914 rs1374437 chr2:178363423 T/C cg22681709 chr2:178499509 PDE11A -0.43 -6.31 -0.36 1.2e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10979 0.597 rs9403515 chr6:143908013 A/G cg25407410 chr6:143891975 LOC285740 -0.49 -6.31 -0.36 1.16e-9 Hypospadias; CESC cis rs1707322 1.000 rs11211236 chr1:46443767 C/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg17376030 chr22:41985996 PMM1 -0.79 -8.18 -0.45 1.18e-14 Vitiligo; CESC cis rs2070488 0.965 rs2051215 chr3:38560345 A/G cg24069376 chr3:38537580 EXOG -0.44 -8.24 -0.45 7.75e-15 Electrocardiographic conduction measures; CESC cis rs9916302 0.821 rs11078916 chr17:37746307 T/C cg15445000 chr17:37608096 MED1 0.34 5.17 0.3 4.63e-7 Glomerular filtration rate (creatinine); CESC cis rs962856 0.619 rs6714988 chr2:67595789 A/G cg09028215 chr2:67624308 ETAA1 -0.44 -5.31 -0.31 2.37e-7 Pancreatic cancer; CESC cis rs7647973 0.848 rs4292260 chr3:49148890 T/C cg06212747 chr3:49208901 KLHDC8B 0.55 6.36 0.36 8.72e-10 Menarche (age at onset); CESC cis rs897984 0.645 rs58726213 chr16:31044683 A/G cg02466173 chr16:30829666 NA -0.41 -7.03 -0.4 1.73e-11 Dementia with Lewy bodies; CESC cis rs9894429 0.966 rs6565605 chr17:79589359 C/T cg21984481 chr17:79567631 NPLOC4 -0.44 -7.08 -0.4 1.26e-11 Eye color traits; CESC trans rs10208443 0.647 rs10203930 chr2:72340402 C/T cg04832019 chr5:28928735 NA -0.45 -6.05 -0.35 4.81e-9 Colorectal adenoma (advanced); CESC cis rs9768139 0.733 rs13309408 chr7:158122261 C/T cg25566285 chr7:158114605 PTPRN2 0.48 7.79 0.43 1.48e-13 Calcium levels; CESC cis rs9658691 0.607 rs9658766 chr10:90771612 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -5.34 -0.31 2e-7 Mosquito bite size; CESC trans rs9467711 0.606 rs9348726 chr6:26605206 G/A cg01620082 chr3:125678407 NA -0.62 -6.25 -0.36 1.59e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2404602 0.692 rs4641709 chr15:77047736 C/T cg22467129 chr15:76604101 ETFA 0.35 5.29 0.31 2.53e-7 Blood metabolite levels; CESC cis rs9584850 0.794 rs17574433 chr13:99138057 A/G cg22223119 chr13:99095684 FARP1 0.4 5.86 0.34 1.4e-8 Neuroticism; CESC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg00149659 chr3:10157352 C3orf10 0.67 7.44 0.42 1.43e-12 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00978910 chr1:172502140 C1orf9 0.57 6.44 0.37 5.74e-10 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.66 9.87 0.52 9.16e-20 Personality dimensions; CESC cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg03433033 chr1:76189801 ACADM 0.76 10.66 0.55 2.64e-22 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1983891 1.000 rs9381080 chr6:41527698 G/C cg20194872 chr6:41519635 FOXP4 0.56 8.09 0.45 2.16e-14 Prostate cancer; CESC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg21784768 chr11:537496 LRRC56 -0.54 -5.08 -0.3 7.13e-7 Body mass index; CESC cis rs17376456 1.000 rs13154249 chr5:93550508 C/T cg21475434 chr5:93447410 FAM172A 0.86 7.53 0.42 7.93e-13 Diabetic retinopathy; CESC cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg11663144 chr21:46675770 NA -0.49 -7.23 -0.41 5.1e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2295359 1.000 rs11465754 chr1:67631431 A/G cg17031739 chr1:67600172 NA 0.37 5.04 0.3 8.77e-7 Psoriasis; CESC cis rs10875746 0.729 rs11168355 chr12:48410978 A/G cg24011408 chr12:48396354 COL2A1 0.42 5.13 0.3 5.74e-7 Longevity (90 years and older); CESC cis rs6964587 1.000 rs9690208 chr7:91735613 T/A cg17063962 chr7:91808500 NA 0.55 7.54 0.42 7.58e-13 Breast cancer; CESC cis rs7267979 0.966 rs2261720 chr20:25260641 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.21e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs9303401 0.646 rs7213269 chr17:57237796 C/T cg12560992 chr17:57184187 TRIM37 0.43 5.13 0.3 5.62e-7 Cognitive test performance; CESC cis rs11077998 0.840 rs9894993 chr17:80481088 T/C cg10255544 chr17:80519551 FOXK2 0.52 8.6 0.47 7.06e-16 Reticulocyte fraction of red cells; CESC cis rs12410462 0.681 rs4486420 chr1:227572321 T/A cg04117972 chr1:227635322 NA 0.74 6.17 0.35 2.52e-9 Major depressive disorder; CESC cis rs9303401 0.614 rs35308719 chr17:57163501 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.92 11.43 0.57 7.38e-25 Cognitive test performance; CESC cis rs35110281 0.616 rs2236666 chr21:45109856 T/C cg01579765 chr21:45077557 HSF2BP -0.53 -8.58 -0.47 8.21e-16 Mean corpuscular volume; CESC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg23758822 chr17:41437982 NA 1.02 15.61 0.69 2.04e-39 Menopause (age at onset); CESC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg26314531 chr2:26401878 FAM59B -0.49 -5.38 -0.31 1.66e-7 Gut microbiome composition (summer); CESC cis rs3845702 1.000 rs3768839 chr2:180835992 G/A cg01881094 chr2:180872142 CWC22 -0.64 -6.76 -0.38 8.55e-11 Schizophrenia; CESC cis rs6032067 1.000 rs6017519 chr20:43854677 C/T cg10761708 chr20:43804764 PI3 0.5 6.15 0.35 2.83e-9 Blood protein levels; CESC cis rs7130144 0.541 rs28875239 chr11:130459571 A/G cg26307797 chr11:130446613 NA -0.74 -6.35 -0.36 9.2e-10 Urate levels in lean individuals; CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg02869306 chr7:64672164 INTS4L1 -0.33 -5.24 -0.31 3.3e-7 Calcium levels; CESC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.6 -7.95 -0.44 5.42e-14 Prudent dietary pattern; CESC cis rs939574 1.000 rs11689596 chr2:220093423 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.63 -6.26 -0.36 1.53e-9 Platelet distribution width; CESC cis rs11676348 0.755 rs6436026 chr2:218951738 T/A cg20019365 chr2:219134978 PNKD;AAMP -0.41 -5.48 -0.32 9.9e-8 Ulcerative colitis; CESC cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg14711859 chr11:8959438 ASCL3 0.31 5.09 0.3 6.89e-7 Hemoglobin concentration; CESC cis rs1003719 0.788 rs9981226 chr21:38452127 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.63 0.47 5.94e-16 Eye color traits; CESC cis rs2688608 0.592 rs7076585 chr10:75503692 T/C cg23231163 chr10:75533350 FUT11 -0.37 -5.57 -0.32 6.38e-8 Inflammatory bowel disease; CESC cis rs367943 0.965 rs463249 chr5:112797430 A/C cg12552261 chr5:112820674 MCC -0.61 -7.57 -0.42 6.33e-13 Type 2 diabetes; CESC cis rs938554 0.571 rs7696092 chr4:10025320 C/A cg00071950 chr4:10020882 SLC2A9 0.71 8.77 0.47 2.19e-16 Blood metabolite levels; CESC cis rs61990749 0.597 rs1477260 chr14:78256818 G/C cg23188588 chr14:78226832 SNW1;C14orf178 0.5 5.14 0.3 5.27e-7 Fibroblast growth factor basic levels; CESC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.16e-7 Aortic root size; CESC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg16049864 chr8:95962084 TP53INP1 -0.63 -10.8 -0.55 9.14e-23 Type 2 diabetes; CESC cis rs425277 0.583 rs925905 chr1:2044037 T/C cg19257562 chr1:2043853 PRKCZ 0.39 6.35 0.36 9.47e-10 Height; CESC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg11965913 chr1:205819406 PM20D1 -0.38 -5.16 -0.3 4.89e-7 Parkinson's disease; CESC cis rs2243480 0.711 rs2420172 chr7:65635341 T/C cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.25e-32 Diabetic kidney disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17697381 chr3:148709363 GYG1 -0.45 -6.25 -0.36 1.62e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6866344 0.697 rs11748497 chr5:178130012 C/G cg03877680 chr5:178157825 ZNF354A 0.76 8.68 0.47 4.16e-16 Neutrophil percentage of white cells; CESC cis rs8062405 0.755 rs55792032 chr16:28599411 A/G cg01378222 chr16:28622494 SULT1A1 0.31 5.24 0.31 3.28e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs7246760 0.867 rs59616842 chr19:9792245 G/A cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs4253772 0.550 rs9615951 chr22:46728056 C/A cg09491104 chr22:46646882 C22orf40 -0.54 -6.11 -0.35 3.62e-9 LDL cholesterol;Cholesterol, total; CESC cis rs4594175 0.847 rs17252303 chr14:51632246 C/T cg23942311 chr14:51606299 NA 0.37 5.53 0.32 7.79e-8 Cancer; CESC cis rs2228479 0.717 rs34027607 chr16:89808939 T/C cg00800038 chr16:89945340 TCF25 -0.71 -7.24 -0.41 4.76e-12 Skin colour saturation; CESC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg03188948 chr7:1209495 NA 0.7 7.31 0.41 3.1e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs8073060 0.586 rs225303 chr17:33922149 A/G cg19694781 chr19:47549865 TMEM160 0.69 6.82 0.39 6.13e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs1559088 0.895 rs7246562 chr19:33546088 T/G cg27124370 chr19:33622961 WDR88 0.48 5.89 0.34 1.17e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs798554 0.704 rs798512 chr7:2782592 C/G cg19717773 chr7:2847554 GNA12 -0.55 -8.64 -0.47 5.3e-16 Height; CESC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC cis rs7432375 0.610 rs56695781 chr3:136510601 G/T cg15507776 chr3:136538369 TMEM22 0.6 8.03 0.44 3.19e-14 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22331096 chr8:128749328 MYC -0.45 -6.2 -0.36 2.11e-9 Fibrinogen levels; CESC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg27170947 chr2:26402098 FAM59B -0.6 -7.11 -0.4 1.08e-11 Gut microbiome composition (summer); CESC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg01448562 chr3:133502909 NA -0.45 -6.22 -0.36 1.92e-9 Iron status biomarkers; CESC cis rs17331151 0.573 rs13080929 chr3:52885112 A/C cg04865290 chr3:52927548 TMEM110 -0.5 -5.31 -0.31 2.3e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs12042938 0.600 rs1094656 chr1:231773675 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.42 5.38 0.31 1.67e-7 Neuranatomic and neurocognitive phenotypes; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00699235 chr12:49962218 MCRS1 -0.47 -6.24 -0.36 1.75e-9 Height; CESC cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg02551604 chr5:131831745 NA -0.37 -5.31 -0.31 2.3e-7 Asthma (sex interaction); CESC cis rs2239908 0.718 rs241776 chr17:26644308 C/T cg10494684 chr17:26645200 TMEM97 0.37 5.12 0.3 5.85e-7 Blood protein levels; CESC cis rs3820928 0.934 rs1366756 chr2:227772038 G/A cg05526886 chr2:227700861 RHBDD1 -0.42 -5.54 -0.32 7.19e-8 Pulmonary function; CESC cis rs2204008 0.805 rs11514348 chr12:38243427 T/C cg13010199 chr12:38710504 ALG10B 0.51 6.3 0.36 1.24e-9 Bladder cancer; CESC cis rs2858942 0.602 rs1211375 chr16:240280 G/T cg00126636 chr16:237282 NA 0.44 6.29 0.36 1.3e-9 Mean corpuscular hemoglobin; CESC cis rs7560272 0.723 rs62153184 chr2:73773869 G/C cg20560298 chr2:73613845 ALMS1 -0.51 -7.31 -0.41 3.21e-12 Schizophrenia; CESC cis rs1707322 1.000 rs11211217 chr1:46348229 C/G cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6736093 0.796 rs13001162 chr2:112805997 C/T cg12686935 chr2:112915763 FBLN7 -0.45 -5.93 -0.34 9.41e-9 Coronary artery disease; CESC cis rs6541297 0.703 rs627702 chr1:230324119 A/G cg20703242 chr1:230279135 GALNT2 0.38 5.13 0.3 5.74e-7 Coronary artery disease; CESC cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg18850127 chr7:39170497 POU6F2 0.39 5.51 0.32 8.29e-8 IgG glycosylation; CESC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg11890956 chr21:40555474 PSMG1 1.15 22.11 0.81 4.18e-62 Cognitive function; CESC cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg18512352 chr11:47633146 NA -0.55 -7.83 -0.43 1.15e-13 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16712549 chr7:39773156 LOC349114 0.59 6.35 0.36 9.26e-10 Gut microbiome composition (summer); CESC cis rs9858542 0.953 rs34363169 chr3:49537712 G/A cg07274523 chr3:49395745 GPX1 0.66 8.05 0.44 2.78e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.5 -7.43 -0.42 1.53e-12 Total body bone mineral density; CESC cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg03709012 chr19:19516395 GATAD2A -0.99 -15.8 -0.7 4.37e-40 Tonsillectomy; CESC cis rs17826219 0.500 rs2874724 chr17:29072433 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Body mass index; CESC cis rs8092503 0.951 rs1833281 chr18:52498801 C/G cg12377874 chr18:52495404 RAB27B 0.37 6.19 0.36 2.23e-9 Childhood body mass index; CESC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg09658497 chr7:2847517 GNA12 -0.41 -5.68 -0.33 3.53e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11367502 chr7:22862612 TOMM7 -0.59 -6.65 -0.38 1.71e-10 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 7.87 0.44 8.99e-14 Menopause (age at onset); CESC cis rs4722166 0.597 rs2069845 chr7:22770149 G/A cg05472934 chr7:22766657 IL6 0.66 9.07 0.49 2.79e-17 Lung cancer; CESC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg03452623 chr4:187889614 NA -0.88 -16.16 -0.7 2.39e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs11608355 0.618 rs60819157 chr12:109795766 G/A cg19025524 chr12:109796872 NA -0.53 -7.65 -0.43 3.83e-13 Neuroticism; CESC cis rs3820068 0.581 rs6666373 chr1:15939884 A/T cg17385448 chr1:15911702 AGMAT 0.41 6.59 0.38 2.42e-10 Systolic blood pressure; CESC cis rs1538970 0.924 rs11211111 chr1:45908782 C/T cg05343316 chr1:45956843 TESK2 0.89 12.04 0.59 6.22e-27 Platelet count; CESC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.83 0.39 5.96e-11 Bipolar disorder; CESC cis rs10484885 0.680 rs72921943 chr6:90581542 A/C cg13799429 chr6:90582589 CASP8AP2 -0.9 -11.56 -0.58 2.77e-25 QRS interval (sulfonylurea treatment interaction); CESC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg00684032 chr4:1343700 KIAA1530 0.39 5.45 0.32 1.15e-7 Obesity-related traits; CESC cis rs2295499 0.754 rs12499320 chr4:2703081 C/T cg08330972 chr4:2403930 ZFYVE28 -0.35 -5.65 -0.33 4.07e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs6088590 0.735 rs6088618 chr20:33409350 G/A cg24642439 chr20:33292090 TP53INP2 0.71 9.4 0.5 2.72e-18 Coronary artery disease; CESC cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 1.97e-28 Colonoscopy-negative controls vs population controls; CESC trans rs7734156 0.500 rs6878067 chr5:115700721 C/G cg17756860 chr4:110510374 CCDC109B 0.42 5.99 0.35 6.67e-9 IgG glycosylation; CESC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg23281280 chr6:28129359 ZNF389 0.56 7.61 0.42 4.91e-13 Depression; CESC cis rs11098499 0.955 rs35434465 chr4:120169378 C/G cg24375607 chr4:120327624 NA 0.44 5.25 0.31 3.14e-7 Corneal astigmatism; CESC cis rs4423214 0.918 rs11233789 chr11:71181085 A/G cg05163923 chr11:71159392 DHCR7 0.82 10.84 0.55 6.81e-23 Vitamin D levels; CESC trans rs11098499 0.866 rs6857892 chr4:120282696 G/T cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC trans rs726288 1.000 rs75164680 chr10:81686133 A/G cg22160595 chr7:72769274 FKBP6 0.97 6.11 0.35 3.52e-9 Rheumatoid arthritis; CESC cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg18512352 chr11:47633146 NA -0.53 -7.95 -0.44 5.27e-14 Subjective well-being; CESC cis rs1008375 0.900 rs10019460 chr4:17686337 T/C cg16339924 chr4:17578868 LAP3 -0.58 -7.01 -0.4 1.92e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9527 0.590 rs1541213 chr10:104885330 A/G cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs4523957 0.579 rs57130712 chr17:2089035 A/G cg16513277 chr17:2031491 SMG6 -0.64 -8.86 -0.48 1.16e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs546131 0.928 rs483976 chr11:34840167 C/G cg06937548 chr11:34938143 PDHX;APIP 0.52 6.41 0.37 6.63e-10 Lung disease severity in cystic fibrosis; CESC trans rs2099077 0.867 rs77180512 chr5:102795939 C/G cg07434438 chr16:72961899 ZFHX3 0.49 6.67 0.38 1.5e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs12079745 0.793 rs78277513 chr1:169414777 A/C cg09363564 chr1:169337483 NME7;BLZF1 -1.11 -6.44 -0.37 5.56e-10 QT interval; CESC cis rs17826219 0.568 rs59858012 chr17:29078582 C/T cg19761014 chr17:28927070 LRRC37B2 0.88 6.51 0.37 3.71e-10 Body mass index; CESC cis rs4727027 0.745 rs10952801 chr7:148864757 T/C cg23583168 chr7:148888333 NA -0.81 -12.7 -0.62 3.49e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg18876405 chr7:65276391 NA -0.53 -7.25 -0.41 4.64e-12 Aortic root size; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02948236 chr16:66864732 NAE1 -0.44 -6.39 -0.37 7.43e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2963155 0.518 rs853179 chr5:142634773 G/T cg17617527 chr5:142782415 NR3C1 0.88 7.89 0.44 7.84e-14 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14569778 chr17:28952111 LRRC37B2 -0.53 -7.05 -0.4 1.57e-11 Gut microbiome composition (summer); CESC cis rs9905704 0.918 rs302858 chr17:56692800 G/T cg12560992 chr17:57184187 TRIM37 0.59 7.02 0.4 1.86e-11 Testicular germ cell tumor; CESC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7216064 0.906 rs78452260 chr17:65848522 G/T cg12091567 chr17:66097778 LOC651250 -0.84 -8.47 -0.46 1.68e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg22920501 chr2:26401640 FAM59B -0.86 -10.17 -0.53 1.03e-20 Gut microbiome composition (summer); CESC cis rs8180040 0.701 rs7617689 chr3:46996442 C/T cg27129171 chr3:47204927 SETD2 -0.66 -9.51 -0.5 1.18e-18 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20719122 chr6:35523700 NA -0.57 -6.46 -0.37 5.07e-10 Gut microbiome composition (summer); CESC cis rs244293 0.965 rs171513 chr17:53190426 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.06 -0.3 7.95e-7 Menarche (age at onset); CESC cis rs754466 0.606 rs3740250 chr10:79580101 C/T cg17075019 chr10:79541650 NA -0.87 -13.65 -0.64 1.81e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg05754148 chr16:3507555 NAT15 -0.64 -6.12 -0.35 3.34e-9 Tuberculosis; CESC cis rs9457247 0.967 rs2149084 chr6:167370988 G/C cg25258033 chr6:167368657 RNASET2 -0.41 -6.12 -0.35 3.35e-9 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26345216 chr11:117747030 FXYD6 -0.55 -6.31 -0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs2370759 1.000 rs11597888 chr10:32635834 G/A cg05361325 chr10:32636312 EPC1 -0.56 -5.21 -0.3 3.82e-7 Sexual dysfunction (female); CESC cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -9.52 -0.5 1.15e-18 Extrinsic epigenetic age acceleration; CESC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg24549020 chr5:56110836 MAP3K1 -0.5 -6.24 -0.36 1.76e-9 Initial pursuit acceleration; CESC cis rs72945132 0.714 rs72947077 chr11:70197431 A/G cg14191688 chr11:70257035 CTTN 0.45 5.31 0.31 2.29e-7 Coronary artery disease; CESC cis rs9309473 0.519 rs2421583 chr2:73898785 C/G cg20560298 chr2:73613845 ALMS1 0.53 7.23 0.41 5.11e-12 Metabolite levels; CESC cis rs10752881 1.000 rs10797807 chr1:182978873 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Colorectal cancer; CESC cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg11752832 chr7:134001865 SLC35B4 0.55 7.21 0.4 6.03e-12 Mean platelet volume; CESC cis rs4555082 0.874 rs11622166 chr14:105759763 C/A cg06808227 chr14:105710500 BRF1 -0.49 -5.28 -0.31 2.72e-7 Mean platelet volume;Platelet distribution width; CESC cis rs2644899 0.859 rs2545757 chr19:41297302 A/G cg10585486 chr19:41304133 EGLN2 -0.36 -5.06 -0.3 7.81e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg21664854 chr7:1097933 C7orf50;GPR146 0.46 6.02 0.35 5.72e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07100957 chr19:58982330 ZNF324 -0.59 -7.36 -0.41 2.28e-12 Gut microbiome composition (summer); CESC cis rs7044106 0.537 rs4434680 chr9:123489688 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 8.1 0.45 2.07e-14 Hip circumference adjusted for BMI; CESC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg14773178 chr5:1868261 NA 0.34 5.96 0.34 7.89e-9 Cardiovascular disease risk factors; CESC cis rs11122272 0.735 rs2486745 chr1:231505717 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.23e-13 Hemoglobin concentration; CESC cis rs12545109 0.879 rs2670015 chr8:57376607 T/A cg09654669 chr8:57350985 NA -0.57 -6.67 -0.38 1.46e-10 Obesity-related traits; CESC cis rs2228479 0.850 rs79244293 chr16:89896220 T/C cg14709524 chr16:89940631 TCF25 0.85 5.79 0.34 1.98e-8 Skin colour saturation; CESC cis rs2354432 1.000 rs2354432 chr1:146693229 C/T cg25205988 chr1:146714368 CHD1L 1.12 12.27 0.6 1.07e-27 Mitochondrial DNA levels; CESC cis rs60871478 1.000 rs62432250 chr7:801792 C/G cg27478167 chr7:817139 HEATR2 -0.5 -5.94 -0.34 9.02e-9 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00567190 chr1:211556508 C1orf97 -0.55 -6.67 -0.38 1.47e-10 Gut microbiome composition (summer); CESC cis rs9948 0.655 rs2280356 chr2:97366324 C/T cg01990225 chr2:97406019 LMAN2L 0.85 7.66 0.43 3.59e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs977987 0.771 rs8048527 chr16:75422054 C/A cg03315344 chr16:75512273 CHST6 0.4 5.75 0.33 2.45e-8 Dupuytren's disease; CESC cis rs1557765 0.527 rs2018218 chr11:17390855 A/G cg15432903 chr11:17409602 KCNJ11 0.43 6.25 0.36 1.64e-9 Body mass index;Social communication problems; CESC cis rs3091242 0.902 rs36003018 chr1:25784318 A/G cg03538708 chr1:25844672 NA 0.38 5.82 0.34 1.66e-8 Erythrocyte sedimentation rate; CESC cis rs9611565 0.649 rs79005 chr22:41835544 G/A cg06634786 chr22:41940651 POLR3H 0.58 6.31 0.36 1.14e-9 Vitiligo; CESC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg07092213 chr7:1199455 ZFAND2A -0.43 -5.68 -0.33 3.61e-8 Longevity;Endometriosis; CESC cis rs7577696 0.597 rs17011801 chr2:32298072 A/T cg02381751 chr2:32503542 YIPF4 -0.42 -5.05 -0.3 8.32e-7 Inflammatory biomarkers; CESC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg05863683 chr7:1912471 MAD1L1 0.36 5.04 0.3 8.49e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4604732 0.588 rs4925551 chr1:247631724 T/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.52 6.44 0.37 5.54e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2415984 0.629 rs7158003 chr14:46919042 T/C cg14871534 chr14:47121158 RPL10L 0.33 5.12 0.3 5.89e-7 Number of children ever born; CESC cis rs1728785 0.688 rs698718 chr16:68560185 A/G cg02972257 chr16:68554789 NA -0.55 -6.38 -0.36 7.91e-10 Ulcerative colitis; CESC cis rs3796352 0.892 rs2581807 chr3:53088844 G/A cg15956490 chr3:53032818 SFMBT1 -0.58 -5.34 -0.31 2.02e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs4843747 0.605 rs4072779 chr16:88107290 C/T cg17633681 chr16:88106987 BANP 0.76 10.51 0.54 8.01e-22 Menopause (age at onset); CESC cis rs11098499 0.738 rs28408407 chr4:120376030 C/G cg09307838 chr4:120376055 NA 0.95 13.84 0.65 3.83e-33 Corneal astigmatism; CESC cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg10556349 chr10:835070 NA 0.63 6.16 0.35 2.76e-9 Eosinophil percentage of granulocytes; CESC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg04944784 chr2:26401820 FAM59B -0.64 -7.3 -0.41 3.46e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03232484 chr7:93633800 BET1 -0.65 -7.85 -0.43 1e-13 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21808837 chr5:176778472 LMAN2 -0.49 -6.49 -0.37 4.24e-10 Asthma; CESC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg12463550 chr7:65579703 CRCP -0.5 -6.41 -0.37 6.59e-10 Aortic root size; CESC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg05332525 chr7:65337924 VKORC1L1 -0.5 -6.12 -0.35 3.44e-9 Aortic root size; CESC cis rs7789940 1.000 rs758944 chr7:75953297 G/T cg10167463 chr7:75959203 YWHAG -0.55 -6.92 -0.39 3.49e-11 Multiple sclerosis; CESC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg04267008 chr7:1944627 MAD1L1 -0.56 -6.59 -0.38 2.37e-10 Bipolar disorder and schizophrenia; CESC cis rs28673728 0.868 rs28380108 chr1:38409103 G/C cg17077180 chr1:38461687 NA 0.46 6.9 0.39 3.83e-11 Red cell distribution width; CESC cis rs11098499 0.954 rs13133522 chr4:120324424 A/T cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs6732160 0.613 rs59979991 chr2:73384422 G/A cg01422370 chr2:73384389 NA 0.56 8.65 0.47 5.08e-16 Intelligence (multi-trait analysis); CESC cis rs7762018 0.891 rs4716343 chr6:170143817 C/G cg05834625 chr6:170176447 C6orf70 0.64 7.17 0.4 7.47e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg15352829 chr14:105391018 PLD4 -0.6 -10.3 -0.53 3.96e-21 Rheumatoid arthritis; CESC cis rs36051895 0.603 rs10123980 chr9:5130363 T/C cg02405213 chr9:5042618 JAK2 -0.49 -6.13 -0.35 3.15e-9 Pediatric autoimmune diseases; CESC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg02725872 chr8:58115012 NA -0.41 -5.49 -0.32 9.22e-8 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg22143856 chr6:28129313 ZNF389 0.51 6.62 0.38 2e-10 Depression; CESC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.91 -0.34 1.05e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs12142240 0.698 rs1057534 chr1:46815880 A/C cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs73001065 0.901 rs8107974 chr19:19388500 A/T cg03709012 chr19:19516395 GATAD2A 0.86 5.57 0.32 6.3e-8 LDL cholesterol; CESC cis rs7131987 0.868 rs11050151 chr12:29403008 T/A cg09582351 chr12:29534625 ERGIC2 -0.34 -5.45 -0.32 1.14e-7 QT interval; CESC cis rs7551222 0.752 rs4252718 chr1:204512195 A/T cg20240347 chr1:204465584 NA 0.27 5.48 0.32 9.92e-8 Schizophrenia; CESC cis rs6754311 0.731 rs2164210 chr2:136580287 T/C cg07169764 chr2:136633963 MCM6 -0.66 -7.98 -0.44 4.39e-14 Mosquito bite size; CESC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg02574844 chr11:5959923 NA -0.43 -5.66 -0.33 3.96e-8 DNA methylation (variation); CESC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg13206674 chr6:150067644 NUP43 0.44 6.42 0.37 6.24e-10 Lung cancer; CESC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg12463550 chr7:65579703 CRCP -0.49 -6.05 -0.35 4.83e-9 Aortic root size; CESC cis rs6570726 0.967 rs450973 chr6:145863065 C/A cg23711669 chr6:146136114 FBXO30 0.73 10.52 0.54 7.61e-22 Lobe attachment (rater-scored or self-reported); CESC trans rs1814175 0.817 rs10839397 chr11:49857074 C/T cg03929089 chr4:120376271 NA -0.91 -15.11 -0.68 1.3e-37 Height; CESC cis rs79057730 0.599 rs4721086 chr7:821123 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.71 6.66 0.38 1.56e-10 Initial pursuit acceleration; CESC cis rs763121 0.853 rs6001204 chr22:39100239 T/C cg06544989 chr22:39130855 UNC84B 0.52 9.9 0.52 7.02e-20 Menopause (age at onset); CESC cis rs826838 1.000 rs11609286 chr12:38875511 A/G cg26384229 chr12:38710491 ALG10B -0.82 -14.2 -0.66 2e-34 Heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11530293 chr8:54935097 TCEA1 0.59 6.44 0.37 5.69e-10 Gut microbiome composition (summer); CESC cis rs7937682 0.883 rs542831 chr11:111471392 T/A cg09085632 chr11:111637200 PPP2R1B -0.93 -13.56 -0.64 3.46e-32 Primary sclerosing cholangitis; CESC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.79 -0.39 7.19e-11 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12478296 0.591 rs4973646 chr2:243001373 C/T cg06360820 chr2:242988706 NA 0.59 7.5 0.42 9.62e-13 Obesity-related traits; CESC cis rs2380220 0.541 rs72928273 chr6:96079360 C/T cg23517279 chr6:96025343 MANEA -0.55 -5.38 -0.31 1.6e-7 Behavioural disinhibition (generation interaction); CESC cis rs9322193 0.884 rs9688858 chr6:149959047 C/A cg07701084 chr6:150067640 NUP43 0.42 5.73 0.33 2.67e-8 Lung cancer; CESC cis rs870825 0.616 rs28500698 chr4:185627746 A/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg19163074 chr7:65112434 INTS4L2 0.43 5.4 0.31 1.5e-7 Aortic root size; CESC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg18252515 chr7:66147081 NA 0.4 5.21 0.3 3.77e-7 Aortic root size; CESC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg18032046 chr6:28092343 ZSCAN16 -0.61 -6.96 -0.39 2.6e-11 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00405494 chr9:7797524 C9orf123 -0.55 -6.32 -0.36 1.08e-9 Gut microbiome composition (summer); CESC cis rs2070433 0.948 rs2839304 chr21:47952650 C/G cg12379764 chr21:47803548 PCNT -0.62 -7.08 -0.4 1.27e-11 Lymphocyte counts; CESC cis rs990171 0.607 rs3917246 chr2:102775164 T/C cg22835712 chr2:102737379 NA 0.42 5.7 0.33 3.18e-8 Lymphocyte counts; CESC cis rs472402 0.623 rs7707877 chr5:6635946 C/G cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.47 -6.26 -0.36 1.51e-9 Response to amphetamines; CESC cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC cis rs12142240 0.698 rs1057534 chr1:46815880 A/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg17971929 chr21:40555470 PSMG1 1.04 15.58 0.69 2.81e-39 Cognitive function; CESC cis rs116979167 0.575 rs818470 chr7:105165350 A/C cg19920283 chr7:105172520 RINT1 0.48 5.41 0.32 1.39e-7 Bipolar disorder (body mass index interaction); CESC cis rs1005277 0.505 rs10827836 chr10:38215441 A/G cg25517755 chr10:38738941 LOC399744 0.39 5.04 0.3 8.48e-7 Extrinsic epigenetic age acceleration; CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg18337363 chr3:52569053 NT5DC2 0.29 5.75 0.33 2.5e-8 Bipolar disorder; CESC cis rs614226 0.935 rs3887875 chr12:120895749 A/G cg27489772 chr12:121021490 NA -0.5 -5.1 -0.3 6.48e-7 Type 1 diabetes nephropathy; CESC cis rs7824557 0.510 rs1435274 chr8:11235910 G/A cg21775007 chr8:11205619 TDH -0.54 -8.05 -0.44 2.9e-14 Retinal vascular caliber; CESC trans rs6089829 0.855 rs4809459 chr20:61661345 C/T cg23505145 chr19:12996616 KLF1 0.52 6.7 0.38 1.24e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs7100689 0.725 rs2487074 chr10:82064104 A/G cg09936400 chr10:82049201 MAT1A 0.36 5.13 0.3 5.74e-7 Post bronchodilator FEV1; CESC cis rs7560272 0.501 rs6755500 chr2:73942233 C/T cg20560298 chr2:73613845 ALMS1 0.43 6.06 0.35 4.77e-9 Schizophrenia; CESC cis rs7208859 0.623 rs6505207 chr17:29076571 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2295499 0.610 rs2239726 chr4:2697089 A/C cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.29 -0.31 2.55e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs13272623 0.502 rs268594 chr8:71513130 C/T cg23757474 chr8:71581111 LACTB2;XKR9 0.42 5.21 0.3 3.89e-7 IgG glycosylation; CESC cis rs3768617 0.811 rs6674729 chr1:183059143 C/T ch.1.3577855R chr1:183094577 LAMC1 0.67 9.27 0.49 6.9e-18 Fuchs's corneal dystrophy; CESC cis rs9527 0.615 rs1556960 chr10:104726673 A/G cg04362960 chr10:104952993 NT5C2 0.42 5.25 0.31 3.14e-7 Arsenic metabolism; CESC cis rs933688 1.000 rs61612071 chr5:90741470 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 12.13 0.6 3.17e-27 Smoking behavior; CESC cis rs11190604 1.000 rs2495747 chr10:102328247 C/T cg07080220 chr10:102295463 HIF1AN 0.56 5.43 0.32 1.31e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs7631605 0.870 rs6775008 chr3:37179031 A/G cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.14 -0.3 5.27e-7 Cerebrospinal P-tau181p levels; CESC cis rs7537052 0.669 rs4652903 chr1:36642858 C/T cg24686825 chr1:36642396 MAP7D1 -0.57 -8.29 -0.45 5.68e-15 Schizophrenia; CESC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg11764359 chr7:65958608 NA -0.78 -11.17 -0.57 5.37e-24 Aortic root size; CESC cis rs9640161 0.659 rs11974980 chr7:150009838 C/T cg21361702 chr7:150065534 REPIN1 0.54 6.29 0.36 1.3e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs8072100 0.744 rs34537623 chr17:45530203 A/G cg25173405 chr17:45401733 C17orf57 -0.42 -5.59 -0.32 5.75e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs796364 0.806 rs203766 chr2:200902672 T/C cg23649088 chr2:200775458 C2orf69 -0.57 -5.24 -0.31 3.23e-7 Schizophrenia; CESC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg03676636 chr4:99064102 C4orf37 -0.4 -5.82 -0.34 1.68e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2559856 0.967 rs2695290 chr12:102087844 A/G cg12213457 chr12:102090980 CHPT1 0.34 5.13 0.3 5.59e-7 Blood protein levels; CESC cis rs2380220 0.541 rs72928273 chr6:96079360 C/T cg04719120 chr6:96025338 MANEA -0.64 -6.74 -0.38 1.01e-10 Behavioural disinhibition (generation interaction); CESC cis rs1580019 0.539 rs11769109 chr7:32571352 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.93 0.76 3.76e-51 Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20175760 chr8:125486985 RNF139 0.54 6.15 0.35 2.92e-9 Gut microbiome composition (summer); CESC cis rs9902453 0.791 rs9904051 chr17:28244122 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.87 0.48 1.08e-16 Coffee consumption (cups per day); CESC cis rs9287719 0.967 rs10454738 chr2:10742049 G/A cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs6032067 0.777 rs13037651 chr20:43782230 C/G cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs2273669 0.667 rs76732622 chr6:109318280 A/T cg05315195 chr6:109294784 ARMC2 -0.66 -5.71 -0.33 3.03e-8 Prostate cancer; CESC cis rs1048238 0.506 rs12039892 chr1:16167974 A/G cg22431228 chr1:16359049 CLCNKA -0.35 -6.1 -0.35 3.76e-9 Systolic blood pressure; CESC cis rs757110 0.770 rs2051772 chr11:17389850 G/A cg15432903 chr11:17409602 KCNJ11 0.58 8.14 0.45 1.5e-14 Type 2 diabetes; CESC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg08470875 chr2:26401718 FAM59B 0.73 7.81 0.43 1.37e-13 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs1860591 chr4:17577329 A/G cg02297831 chr4:17616191 MED28 0.45 5.51 0.32 8.4e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs238295 0.805 rs6053499 chr20:5542546 C/T cg24001556 chr20:5591874 RP5-1022P6.2 -0.46 -5.49 -0.32 9.48e-8 Occipital cortical area (total cortical area interaction); CESC cis rs9815354 0.812 rs17218264 chr3:41975847 C/T cg03022575 chr3:42003672 ULK4 -0.73 -6.33 -0.36 1.02e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs1950626 0.699 rs12880855 chr14:101468382 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.82 10.28 0.53 4.42e-21 Pelvic organ prolapse (moderate/severe); CESC cis rs9300255 0.544 rs1790130 chr12:123701270 A/C cg05973401 chr12:123451056 ABCB9 0.49 5.63 0.33 4.65e-8 Neutrophil percentage of white cells; CESC trans rs4332037 0.539 rs56180486 chr7:2050747 C/T cg11693508 chr17:37793320 STARD3 0.68 6.8 0.39 7.12e-11 Bipolar disorder; CESC trans rs1814175 0.646 rs61904497 chr11:49883449 A/T cg11707556 chr5:10655725 ANKRD33B -0.43 -6.27 -0.36 1.42e-9 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04669830 chr20:1306048 SDCBP2 -0.47 -6.0 -0.35 6.36e-9 Fibrinogen levels; CESC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg04546413 chr19:29218101 NA 0.48 7.53 0.42 7.81e-13 Methadone dose in opioid dependence; CESC cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 6.1e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs3204270 0.684 rs62080212 chr17:79642500 G/A cg18367735 chr17:79674897 NA 0.62 5.34 0.31 2e-7 Dental caries; CESC cis rs2243480 1.000 rs316326 chr7:65609453 T/C cg12463550 chr7:65579703 CRCP 0.75 5.84 0.34 1.56e-8 Diabetic kidney disease; CESC cis rs1983891 1.000 rs1983891 chr6:41536427 A/G cg20194872 chr6:41519635 FOXP4 -0.54 -7.75 -0.43 1.91e-13 Prostate cancer; CESC cis rs9300255 0.596 rs10732573 chr12:123743883 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.33 -5.04 -0.3 8.7e-7 Neutrophil percentage of white cells; CESC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg17911788 chr17:44343683 NA 0.43 6.78 0.38 7.61e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2777491 0.957 rs8027626 chr15:41711514 T/G cg02330683 chr15:41787940 ITPKA 0.48 7.01 0.4 2.03e-11 Ulcerative colitis; CESC cis rs501120 1.000 rs479596 chr10:44760473 C/T cg09554077 chr10:44749378 NA 0.54 6.01 0.35 6.28e-9 Coronary artery disease;Coronary heart disease; CESC cis rs826838 0.967 rs6580726 chr12:39108623 T/C cg26384229 chr12:38710491 ALG10B -0.63 -10.23 -0.53 6.29e-21 Heart rate; CESC cis rs2425143 0.818 rs2378414 chr20:34534374 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.58 0.32 6.02e-8 Blood protein levels; CESC cis rs2933343 0.859 rs789247 chr3:128580585 C/A cg25356066 chr3:128598488 ACAD9 0.56 7.08 0.4 1.26e-11 IgG glycosylation; CESC cis rs3741151 1.000 rs74795285 chr11:73033387 A/G cg17517138 chr11:73019481 ARHGEF17 0.98 7.03 0.4 1.72e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07496882 chr10:112631570 LOC282997;PDCD4 -0.39 -6.11 -0.35 3.54e-9 Gambling; CESC cis rs698813 0.573 rs6544750 chr2:44490780 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.63 0.33 4.62e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg00149659 chr3:10157352 C3orf10 -0.74 -9.41 -0.5 2.42e-18 Alzheimer's disease; CESC cis rs3020736 0.500 rs1801311 chr22:42486723 G/A cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11427898 chr15:38544983 SPRED1 0.59 6.45 0.37 5.16e-10 Gut microbiome composition (summer); CESC cis rs8016982 0.633 rs4363794 chr14:81674327 C/A cg01989461 chr14:81687754 GTF2A1 0.71 10.37 0.54 2.35e-21 Schizophrenia; CESC trans rs7980799 0.933 rs11052705 chr12:33588388 T/C cg26384229 chr12:38710491 ALG10B -0.53 -7.19 -0.4 6.53e-12 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs13095912 1.000 rs13100229 chr3:185343200 C/T cg11274856 chr3:185301563 NA 0.34 5.49 0.32 9.47e-8 Systolic blood pressure; CESC cis rs713587 0.875 rs6746013 chr2:25143649 C/G cg01884057 chr2:25150051 NA 0.42 7.97 0.44 4.79e-14 Body mass index in non-asthmatics; CESC cis rs7843479 0.526 rs34802507 chr8:21773853 C/T cg17168535 chr8:21777572 XPO7 0.66 9.78 0.51 1.76e-19 Mean corpuscular volume; CESC cis rs4561483 0.801 rs33631 chr16:11995387 G/C cg08843971 chr16:11963173 GSPT1 -0.55 -8.04 -0.44 3.03e-14 Testicular germ cell tumor; CESC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg02951883 chr7:2050386 MAD1L1 -0.52 -6.84 -0.39 5.42e-11 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs921968 0.540 rs10190250 chr2:219457731 C/T cg02176678 chr2:219576539 TTLL4 -0.52 -9.12 -0.49 1.94e-17 Mean corpuscular hemoglobin concentration; CESC cis rs7794273 0.723 rs2588638 chr7:18844596 C/T cg13420273 chr7:18810212 HDAC9 0.37 5.12 0.3 5.91e-7 Night sleep phenotypes; CESC cis rs7274811 0.711 rs291697 chr20:31985248 T/C cg21523528 chr20:32077966 CBFA2T2 -0.49 -5.66 -0.33 3.98e-8 Height; CESC cis rs11247915 0.561 rs12750420 chr1:26608649 G/A cg00852783 chr1:26633632 UBXN11 0.41 5.12 0.3 5.9e-7 Obesity-related traits; CESC cis rs2625529 0.627 rs12898585 chr15:72473928 T/C cg16672083 chr15:72433130 SENP8 -0.39 -5.25 -0.31 3.16e-7 Red blood cell count; CESC cis rs754466 0.580 rs2289311 chr10:79565655 G/A cg17075019 chr10:79541650 NA -0.83 -12.74 -0.62 2.47e-29 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2070488 0.804 rs13092539 chr3:38458725 G/A cg24069376 chr3:38537580 EXOG 0.35 6.01 0.35 6.11e-9 Electrocardiographic conduction measures; CESC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg20151795 chr6:28129481 ZNF389 0.39 5.25 0.31 3.17e-7 Depression; CESC cis rs9611565 0.625 rs12483991 chr22:41935285 A/G cg06481639 chr22:41940642 POLR3H -0.5 -5.69 -0.33 3.37e-8 Vitiligo; CESC cis rs7020830 0.931 rs1388978 chr9:37144062 G/T cg14294708 chr9:37120828 ZCCHC7 1.14 21.7 0.8 9.94e-61 Schizophrenia; CESC cis rs12142240 0.698 rs28578741 chr1:46825176 T/C cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs11690935 0.851 rs10174055 chr2:172858214 C/T cg13550731 chr2:172543902 DYNC1I2 -0.8 -10.87 -0.56 5.4e-23 Schizophrenia; CESC cis rs6088580 0.634 rs4911423 chr20:32999386 T/A cg08999081 chr20:33150536 PIGU -0.65 -11.34 -0.57 1.5e-24 Glomerular filtration rate (creatinine); CESC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg18876405 chr7:65276391 NA -0.53 -6.89 -0.39 3.98e-11 Aortic root size; CESC cis rs79349575 0.715 rs999474 chr17:46987665 G/A cg16584676 chr17:46985605 UBE2Z -0.71 -9.25 -0.49 8.03e-18 Type 2 diabetes; CESC cis rs4727963 0.846 rs953563 chr7:122714001 A/C cg03640110 chr7:122635026 TAS2R16 -0.36 -5.64 -0.33 4.46e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs9303280 0.806 rs62067034 chr17:38063738 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.53 -0.32 7.55e-8 Self-reported allergy; CESC cis rs7843479 0.544 rs7839925 chr8:21792983 G/C cg17168535 chr8:21777572 XPO7 0.7 11.35 0.57 1.4e-24 Mean corpuscular volume; CESC cis rs1801251 1.000 rs71421663 chr2:233619131 A/G cg25237894 chr2:233734115 C2orf82 0.45 7.9 0.44 7.6e-14 Coronary artery disease; CESC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs9796 0.663 rs11853192 chr15:41368515 G/A cg12426344 chr15:41135900 SPINT1 -0.24 -5.28 -0.31 2.69e-7 Menopause (age at onset); CESC cis rs826838 0.935 rs3886109 chr12:39189243 C/T cg26384229 chr12:38710491 ALG10B 0.78 13.13 0.63 1.09e-30 Heart rate; CESC cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg21395723 chr22:39101663 GTPBP1 -0.44 -5.33 -0.31 2.14e-7 Menopause (age at onset); CESC cis rs8014204 0.657 rs2884668 chr14:75281576 T/A cg08847533 chr14:75593920 NEK9 0.4 5.25 0.31 3.13e-7 Caffeine consumption; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16075951 chr14:24899050 CBLN3;KHNYN 0.56 6.53 0.37 3.37e-10 Gut microbiome composition (summer); CESC cis rs2367563 0.927 rs2367562 chr12:96057213 G/A cg19013339 chr12:96052514 NTN4 0.36 5.19 0.3 4.22e-7 Allergic dermatitis (nickel); CESC trans rs6084875 0.538 rs2093389 chr20:4723262 T/C cg10192164 chr16:30419175 ZNF771 -0.51 -6.18 -0.35 2.44e-9 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs861020 0.771 rs1962735 chr1:210012102 A/G cg05527609 chr1:210001259 C1orf107 0.89 12.02 0.59 7.35e-27 Orofacial clefts; CESC trans rs2764766 0.789 rs245313 chr5:127165481 A/G cg15764593 chr10:829463 NA 0.4 6.27 0.36 1.46e-9 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21028292 chr3:129158769 IFT122;MBD4 0.56 6.65 0.38 1.65e-10 Gut microbiome composition (summer); CESC trans rs7944735 0.817 rs747782 chr11:47940925 A/G cg15704280 chr7:45808275 SEPT13 0.56 6.07 0.35 4.45e-9 Intraocular pressure; CESC cis rs7772486 0.846 rs1331636 chr6:146338826 T/C cg05347473 chr6:146136440 FBXO30 0.52 6.71 0.38 1.17e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs12220238 1.000 rs12220238 chr10:75952670 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.64 5.45 0.32 1.16e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg21918786 chr6:109611834 NA -0.35 -5.03 -0.3 8.9e-7 Reticulocyte fraction of red cells; CESC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg17949981 chr6:28129498 ZNF389 0.39 5.1 0.3 6.36e-7 Parkinson's disease; CESC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.31e-9 Developmental language disorder (linguistic errors); CESC cis rs4142995 0.962 rs1917368 chr7:17911752 G/T cg03009463 chr7:17980271 SNX13 -0.37 -5.04 -0.3 8.51e-7 HDL cholesterol;HDL cholesterol levels; CESC trans rs7937682 0.889 rs542424 chr11:111477698 T/C cg18187862 chr3:45730750 SACM1L 0.48 6.1 0.35 3.71e-9 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10937591 chr1:112532966 KCND3 -0.54 -6.32 -0.36 1.08e-9 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg05368731 chr17:41323189 NBR1 0.77 10.06 0.53 2.31e-20 Menopause (age at onset); CESC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg00166722 chr3:10149974 C3orf24 0.51 6.31 0.36 1.19e-9 Alzheimer's disease; CESC cis rs854765 0.583 rs6502619 chr17:17779704 C/G cg04398451 chr17:18023971 MYO15A 0.64 8.99 0.48 4.72e-17 Total body bone mineral density; CESC cis rs2075371 1.000 rs2598297 chr7:133993001 T/G cg11752832 chr7:134001865 SLC35B4 0.55 7.12 0.4 1.03e-11 Mean platelet volume; CESC cis rs7103648 0.735 rs3824869 chr11:47378245 T/C cg20307385 chr11:47447363 PSMC3 -0.9 -12.82 -0.62 1.39e-29 Diastolic blood pressure;Systolic blood pressure; CESC cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg06544989 chr22:39130855 UNC84B 0.52 9.08 0.49 2.57e-17 Menopause (age at onset); CESC cis rs4642101 0.793 rs56082700 chr3:12833833 T/C cg05775895 chr3:12838266 CAND2 0.36 5.4 0.31 1.49e-7 QRS complex (12-leadsum); CESC cis rs11785400 1.000 rs13266249 chr8:143732433 A/C cg24634471 chr8:143751801 JRK 0.46 6.05 0.35 4.84e-9 Schizophrenia; CESC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg25767906 chr1:53392781 SCP2 -0.49 -6.21 -0.36 2.04e-9 Monocyte count; CESC trans rs1728785 0.901 rs1645934 chr16:68564490 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs1633360 1 rs1633360 chr12:58108052 C/T cg18357645 chr12:58087776 OS9 0.55 9.25 0.49 8e-18 Rheumatoid arthritis; CESC cis rs694739 1.000 rs11231757 chr11:64106317 C/T cg23796481 chr11:64053134 BAD;GPR137 0.67 8.68 0.47 4.13e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs6674176 0.542 rs3011225 chr1:44319373 G/A cg12908607 chr1:44402522 ARTN -0.4 -5.48 -0.32 9.78e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs13095912 0.962 rs12374077 chr3:185317674 G/C cg11274856 chr3:185301563 NA 0.36 5.87 0.34 1.33e-8 Systolic blood pressure; CESC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg00149659 chr3:10157352 C3orf10 0.76 9.52 0.5 1.17e-18 Alzheimer's disease; CESC cis rs6665290 0.904 rs11587443 chr1:227187896 T/C cg10327440 chr1:227177885 CDC42BPA -1.21 -32.66 -0.89 6.96e-95 Myeloid white cell count; CESC cis rs9291683 0.566 rs13115776 chr4:10040189 C/G cg02734326 chr4:10020555 SLC2A9 0.46 6.33 0.36 1.02e-9 Bone mineral density; CESC cis rs11792861 0.591 rs7044275 chr9:111717138 T/C cg13535736 chr9:111863775 C9orf5 -0.39 -5.72 -0.33 2.88e-8 Menarche (age at onset); CESC cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg24110177 chr3:50126178 RBM5 0.58 8.14 0.45 1.55e-14 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04039414 chr16:27280154 NSMCE1 0.58 6.35 0.36 9.38e-10 Gut microbiome composition (summer); CESC cis rs3820068 0.603 rs6429769 chr1:15968610 C/G cg17385448 chr1:15911702 AGMAT 0.4 6.77 0.38 8.36e-11 Systolic blood pressure; CESC cis rs3916 0.641 rs7964786 chr12:121132100 C/T cg00257296 chr12:120799373 MSI1 0.35 5.38 0.31 1.67e-7 Urinary metabolites (H-NMR features); CESC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.79 -0.55 9.49e-23 Alzheimer's disease; CESC cis rs7511006 0.798 rs11703673 chr22:50652427 A/G cg16473166 chr22:50639996 SELO -0.49 -5.59 -0.32 5.55e-8 Obesity-related traits; CESC cis rs2228479 0.702 rs78331410 chr16:89917775 C/T cg00800038 chr16:89945340 TCF25 -0.91 -6.93 -0.39 3.21e-11 Skin colour saturation; CESC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg24578937 chr1:2090814 PRKCZ 0.36 6.52 0.37 3.48e-10 Height; CESC cis rs2243480 1.000 rs462853 chr7:65558167 G/C cg18252515 chr7:66147081 NA -1.39 -13.81 -0.65 4.83e-33 Diabetic kidney disease; CESC cis rs941408 0.515 rs1640262 chr19:2779134 C/T cg02580895 chr19:2754563 NA 0.47 6.55 0.37 2.94e-10 Total cholesterol levels; CESC cis rs9611565 0.694 rs202641 chr22:41833116 C/T cg06634786 chr22:41940651 POLR3H 0.56 6.12 0.35 3.39e-9 Vitiligo; CESC cis rs2228479 0.618 rs34689166 chr16:89860697 C/T cg19635926 chr16:89946313 TCF25 0.68 5.17 0.3 4.65e-7 Skin colour saturation; CESC cis rs9908102 0.740 rs733890 chr17:12918054 C/T cg26162695 chr17:12921313 ELAC2 0.54 5.91 0.34 1.06e-8 Schizophrenia; CESC cis rs9902453 0.808 rs76039587 chr17:28233760 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.2 0.45 1.05e-14 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23203684 chr5:76326465 AGGF1 0.53 6.03 0.35 5.51e-9 Gut microbiome composition (summer); CESC cis rs2730245 0.527 rs2527197 chr7:158735260 G/A cg24397884 chr7:158709396 WDR60 -0.86 -9.09 -0.49 2.37e-17 Height; CESC cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg00033643 chr7:134001901 SLC35B4 0.42 5.38 0.31 1.61e-7 Mean platelet volume; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg19524972 chr12:121647936 P2RX4 0.53 6.26 0.36 1.52e-9 Psoriatic arthritis; CESC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg16325326 chr1:53192061 ZYG11B 0.83 12.87 0.62 8.73e-30 Monocyte count; CESC cis rs3806843 0.966 rs2563265 chr5:140137005 C/T cg26395211 chr5:140044315 WDR55 0.45 5.79 0.34 1.97e-8 Depressive symptoms (multi-trait analysis); CESC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg21285383 chr16:89894308 SPIRE2 -0.28 -5.05 -0.3 8.36e-7 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24723716 chr1:244998845 FAM36A 0.59 6.11 0.35 3.47e-9 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg19077165 chr18:44547161 KATNAL2 -0.55 -8.14 -0.45 1.51e-14 Personality dimensions; CESC cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg00684032 chr4:1343700 KIAA1530 0.36 5.18 0.3 4.32e-7 Obesity-related traits; CESC cis rs9790314 0.875 rs459515 chr3:161092351 T/C cg03342759 chr3:160939853 NMD3 -0.41 -5.4 -0.31 1.49e-7 Morning vs. evening chronotype; CESC cis rs9911578 0.874 rs302874 chr17:56767996 A/G cg12560992 chr17:57184187 TRIM37 0.94 15.2 0.68 6.12e-38 Intelligence (multi-trait analysis); CESC cis rs9911578 1.000 rs302859 chr17:56693132 C/T cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC cis rs75477785 1.000 rs12563527 chr1:210054211 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.8 5.19 0.3 4.2e-7 Cleft lip with or without cleft palate; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24336590 chr1:120396074 NA 0.5 6.98 0.39 2.34e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg25072359 chr17:41440525 NA 0.48 6.35 0.36 9.3e-10 Menopause (age at onset); CESC cis rs17376456 0.825 rs17314762 chr5:93231200 C/T cg21475434 chr5:93447410 FAM172A 0.82 6.99 0.39 2.2e-11 Diabetic retinopathy; CESC cis rs6066835 0.572 rs12329434 chr20:47260191 T/C cg18078177 chr20:47281410 PREX1 0.67 5.03 0.3 8.94e-7 Multiple myeloma; CESC trans rs1728785 1.000 rs1170442 chr16:68574064 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC trans rs7246760 1.000 rs56754106 chr19:9937789 T/A cg02900749 chr2:68251473 NA -0.82 -6.85 -0.39 5.23e-11 Pursuit maintenance gain; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12784848 chr8:23081957 TNFRSF10A -0.48 -6.07 -0.35 4.39e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg20962211 chr2:183580829 DNAJC10 0.5 6.59 0.38 2.32e-10 Breast cancer;Type 2 diabetes; CESC cis rs736801 0.780 rs2188962 chr5:131770805 C/T cg21138405 chr5:131827807 IRF1 -0.36 -5.23 -0.31 3.37e-7 Breast cancer;Mosquito bite size; CESC cis rs7100689 0.646 rs7899791 chr10:82091950 A/T cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 4.91e-14 Post bronchodilator FEV1; CESC cis rs873946 0.564 rs12242672 chr10:134555609 A/T cg18305652 chr10:134549665 INPP5A 0.5 7.58 0.42 5.94e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs950776 0.518 rs28438420 chr15:78836288 A/T cg06917634 chr15:78832804 PSMA4 -0.68 -10.17 -0.53 9.91e-21 Sudden cardiac arrest; CESC trans rs208520 0.770 rs1342960 chr6:66883514 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.49 -0.58 4.62e-25 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08697244 chr7:6487510 DAGLB 0.55 6.01 0.35 6.15e-9 Gut microbiome composition (summer); CESC cis rs7692995 1.000 rs16896312 chr4:18030853 C/T cg08925142 chr4:18023851 LCORL -0.43 -5.03 -0.3 9e-7 Height; CESC cis rs2247341 0.965 rs2854917 chr4:1720550 T/C cg07465881 chr4:1713556 SLBP -0.53 -6.58 -0.37 2.51e-10 Hip circumference adjusted for BMI;Height; CESC cis rs1008375 1.000 rs3815414 chr4:17606659 A/G cg02297831 chr4:17616191 MED28 -0.49 -6.18 -0.35 2.43e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9324022 0.656 rs72698711 chr14:101167563 C/T cg18089426 chr14:101175970 NA 0.56 5.88 0.34 1.25e-8 Plateletcrit; CESC cis rs1559088 0.749 rs10405757 chr19:33616526 C/A cg17764715 chr19:33622953 WDR88 0.45 5.85 0.34 1.45e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs644799 0.710 rs3017756 chr11:95537358 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.76 10.93 0.56 3.47e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7116495 0.609 rs7113520 chr11:71691946 G/A cg07596299 chr11:71824057 C11orf51 -0.87 -5.46 -0.32 1.08e-7 Severe influenza A (H1N1) infection; CESC cis rs11719291 0.833 rs11713694 chr3:48833615 G/T cg00383909 chr3:49044727 WDR6 0.92 6.66 0.38 1.62e-10 Cognitive function; CESC cis rs9902453 0.967 rs1906451 chr17:28515479 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 7.44 0.42 1.38e-12 Coffee consumption (cups per day); CESC cis rs1790761 0.587 rs7934075 chr11:67295949 T/C cg24690094 chr11:67383802 NA -0.34 -5.91 -0.34 1.05e-8 Mean corpuscular volume; CESC cis rs1707322 0.929 rs785513 chr1:46538320 T/C cg06784218 chr1:46089804 CCDC17 -0.35 -5.93 -0.34 9.27e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3026101 0.624 rs1065483 chr17:5284770 C/T cg24500398 chr17:5266808 RABEP1 -0.41 -5.92 -0.34 9.97e-9 Body mass index; CESC cis rs477692 1.000 rs506274 chr10:131409392 T/A cg05714579 chr10:131428358 MGMT 0.49 6.54 0.37 3.2e-10 Response to temozolomide; CESC cis rs7560272 0.512 rs12998980 chr2:73930726 A/C cg20560298 chr2:73613845 ALMS1 0.46 6.35 0.36 9.43e-10 Schizophrenia; CESC cis rs8077577 0.747 rs62072511 chr17:18193157 G/A cg16794390 chr17:18148240 FLII 0.41 6.45 0.37 5.26e-10 Obesity-related traits; CESC cis rs1927790 0.637 rs7337506 chr13:96936978 G/A cg02571835 chr13:96230311 CLDN10 -0.39 -5.51 -0.32 8.55e-8 Body mass index; CESC cis rs7674212 0.570 rs2251634 chr4:104082349 C/T cg16532752 chr4:104119610 CENPE -0.45 -6.18 -0.36 2.37e-9 Type 2 diabetes; CESC cis rs4481887 0.927 rs10888344 chr1:248446655 T/C cg00666640 chr1:248458726 OR2T12 0.37 6.47 0.37 4.71e-10 Common traits (Other); CESC cis rs7250872 0.568 rs749109 chr19:1819736 G/A cg05970437 chr19:1864622 KLF16 0.49 5.7 0.33 3.2e-8 Bipolar disorder; CESC cis rs642803 0.613 rs489574 chr11:65542739 C/T cg02870584 chr11:65547924 DKFZp761E198 0.54 6.83 0.39 5.85e-11 Urate levels; CESC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg22920501 chr2:26401640 FAM59B -0.67 -8.12 -0.45 1.72e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26010175 chr3:135969053 PCCB 0.61 7.05 0.4 1.59e-11 Gut microbiome composition (summer); CESC cis rs910316 1.000 rs12897094 chr14:75579416 C/T cg08847533 chr14:75593920 NEK9 1.0 19.67 0.77 9.95e-54 Height; CESC trans rs73660619 0.818 rs3943652 chr8:3084216 C/T cg21503148 chr8:786831 NA 0.55 6.09 0.35 3.85e-9 Alzheimer's disease (cognitive decline); CESC cis rs1728785 0.901 rs933713 chr16:68581378 C/A cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs6598955 0.671 rs6658935 chr1:26568912 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.38 5.44 0.32 1.21e-7 Obesity-related traits; CESC cis rs977987 0.843 rs10871312 chr16:75486202 C/T cg03315344 chr16:75512273 CHST6 0.46 6.53 0.37 3.27e-10 Dupuytren's disease; CESC cis rs6570726 0.526 rs9376928 chr6:145724403 T/G cg23711669 chr6:146136114 FBXO30 -0.53 -7.12 -0.4 1.01e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs7726839 0.540 rs72703080 chr5:595238 A/G cg25482853 chr8:67687455 SGK3 1.01 8.93 0.48 7.38e-17 Obesity-related traits; CESC cis rs7524258 1.000 rs7524258 chr1:7292229 T/C cg07173049 chr1:7289937 CAMTA1 0.41 6.47 0.37 4.67e-10 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg23048001 chr7:2026167 MAD1L1 0.44 5.9 0.34 1.11e-8 Schizophrenia; CESC cis rs12681288 0.676 rs2701927 chr8:995886 G/A cg04851639 chr8:1020857 NA -0.35 -7.48 -0.42 1.12e-12 Schizophrenia; CESC trans rs877282 0.891 rs34652870 chr10:772218 T/C cg22713356 chr15:30763199 NA 1.26 12.75 0.62 2.39e-29 Uric acid levels; CESC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.42 -5.79 -0.33 2.02e-8 Bipolar disorder; CESC cis rs7264396 0.676 rs6060729 chr20:34557004 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.29 -0.53 4.22e-21 Total cholesterol levels; CESC cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg08847533 chr14:75593920 NEK9 -0.92 -15.1 -0.68 1.37e-37 Height; CESC cis rs4909189 1.000 rs4909189 chr7:158136986 A/T cg25566285 chr7:158114605 PTPRN2 -0.45 -6.22 -0.36 1.93e-9 Response to amphetamines; CESC cis rs7917772 0.582 rs4919665 chr10:104366042 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -5.79 -0.34 1.97e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2439831 0.867 rs2584702 chr15:43684914 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.91 11.14 0.56 6.61e-24 Lung cancer in ever smokers; CESC cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg05283184 chr6:79620031 NA -0.43 -6.84 -0.39 5.35e-11 Intelligence (multi-trait analysis); CESC cis rs6121246 0.908 rs17093657 chr20:30428894 G/A cg13852791 chr20:30311386 BCL2L1 0.75 7.48 0.42 1.09e-12 Mean corpuscular hemoglobin; CESC cis rs9811920 0.609 rs13317017 chr3:99665521 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.58 -7.0 -0.39 2.14e-11 Axial length; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg08619119 chr6:13575098 SIRT5 0.52 6.56 0.37 2.75e-10 Retinol levels; CESC cis rs3126085 0.935 rs4511113 chr1:152222192 G/A cg03465714 chr1:152285911 FLG -0.42 -5.17 -0.3 4.56e-7 Atopic dermatitis; CESC cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7020830 0.898 rs506981 chr9:37351348 A/T cg14294708 chr9:37120828 ZCCHC7 -1.0 -17.3 -0.73 2.23e-45 Schizophrenia; CESC cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg07636037 chr3:49044803 WDR6 1.07 19.04 0.76 1.57e-51 Parkinson's disease; CESC cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg05347473 chr6:146136440 FBXO30 0.56 7.17 0.4 7.56e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs116095464 0.558 rs59113266 chr5:279965 T/C cg10591111 chr5:226296 SDHA -0.53 -6.43 -0.37 6.03e-10 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12857652 chr6:64289969 PTP4A1 -0.67 -7.85 -0.43 1.05e-13 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17967426 chr5:168006763 PANK3 -0.53 -7.04 -0.4 1.63e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6570726 0.935 rs380433 chr6:145859601 A/T cg23711669 chr6:146136114 FBXO30 0.8 11.74 0.58 6.58e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs7267979 0.933 rs6138571 chr20:25435388 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.57 0.73 2.33e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs476633 0.691 rs6492997 chr15:41541171 G/A cg18705301 chr15:41695430 NDUFAF1 -0.47 -6.78 -0.38 7.93e-11 Glomerular filtration rate (creatinine); CESC cis rs2735413 0.914 rs2262658 chr16:78060267 A/G cg04733911 chr16:78082701 NA -0.45 -7.04 -0.4 1.69e-11 Systolic blood pressure (alcohol consumption interaction); CESC trans rs6951245 0.507 rs11976805 chr7:1138716 C/T cg13565492 chr6:43139072 SRF -0.6 -7.26 -0.41 4.42e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg18252515 chr7:66147081 NA -1.25 -12.55 -0.61 1.18e-28 Diabetic kidney disease; CESC cis rs9902453 0.933 rs7224199 chr17:28523726 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 7.34 0.41 2.67e-12 Coffee consumption (cups per day); CESC cis rs2191566 0.959 rs7256345 chr19:44510905 T/G cg20607764 chr19:44506953 ZNF230 -0.6 -7.8 -0.43 1.4e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg20607287 chr7:12443886 VWDE -0.68 -9.85 -0.52 1.04e-19 Coronary artery disease; CESC cis rs847577 0.630 rs3801294 chr7:97822210 G/A cg21770322 chr7:97807741 LMTK2 0.86 14.68 0.67 4.05e-36 Breast cancer; CESC cis rs6580649 0.783 rs1635526 chr12:48396785 C/T cg05342945 chr12:48394962 COL2A1 -0.54 -6.54 -0.37 3.07e-10 Lung cancer; CESC trans rs561341 0.505 rs548298 chr17:30297494 C/A cg27661571 chr11:113659931 NA -0.72 -7.36 -0.41 2.36e-12 Hip circumference adjusted for BMI; CESC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg07936489 chr17:37558343 FBXL20 0.82 11.93 0.59 1.54e-26 Glomerular filtration rate (creatinine); CESC cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg20503657 chr10:835505 NA 1.1 9.65 0.51 4.39e-19 Eosinophil percentage of granulocytes; CESC cis rs1707322 1.000 rs11211244 chr1:46456673 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7520050 0.933 rs9787208 chr1:46314616 C/A cg24296786 chr1:45957014 TESK2 0.42 5.42 0.32 1.33e-7 Red blood cell count;Reticulocyte count; CESC cis rs11098499 0.954 rs7436506 chr4:120393769 T/C cg24375607 chr4:120327624 NA 0.45 5.74 0.33 2.61e-8 Corneal astigmatism; CESC cis rs643506 0.874 rs663511 chr11:111710034 T/C cg09085632 chr11:111637200 PPP2R1B 0.42 5.38 0.31 1.61e-7 Breast cancer; CESC cis rs12347191 0.500 rs907578 chr9:100622883 A/G cg13688889 chr9:100608707 NA -0.89 -13.0 -0.62 3.11e-30 Orofacial clefts; CESC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg08888203 chr3:10149979 C3orf24 0.49 6.29 0.36 1.3e-9 Alzheimer's disease; CESC cis rs9457247 0.624 rs9457260 chr6:167466665 C/T cg07741184 chr6:167504864 NA 0.37 6.49 0.37 4.2e-10 Crohn's disease; CESC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg08499158 chr17:42289980 UBTF 0.49 6.16 0.35 2.69e-9 Total body bone mineral density; CESC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg07936489 chr17:37558343 FBXL20 -0.79 -11.25 -0.57 3.02e-24 Glomerular filtration rate (creatinine); CESC cis rs7131987 0.903 rs67150462 chr12:29393325 T/C cg09582351 chr12:29534625 ERGIC2 -0.32 -5.1 -0.3 6.58e-7 QT interval; CESC cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg05347473 chr6:146136440 FBXO30 0.74 9.49 0.5 1.41e-18 Lobe attachment (rater-scored or self-reported); CESC cis rs7267979 1.000 rs2259873 chr20:25280781 A/G cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7772486 0.875 rs2814871 chr6:146312274 G/T cg05347473 chr6:146136440 FBXO30 0.53 7.1 0.4 1.18e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs8064299 0.574 rs1879455 chr17:72774738 C/G cg25054828 chr17:72772726 NAT9;TMEM104 0.83 13.9 0.65 2.3e-33 Monocyte count; CESC cis rs9815354 0.951 rs9849393 chr3:41875369 G/C cg03022575 chr3:42003672 ULK4 0.58 6.01 0.35 5.96e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs909674 0.690 rs5750825 chr22:39831278 A/G cg02038168 chr22:39784481 NA -0.66 -8.52 -0.46 1.24e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7095944 0.614 rs11245354 chr10:126450125 C/A cg08799069 chr10:126477246 METTL10 -0.35 -5.15 -0.3 5.19e-7 Asthma; CESC cis rs7794273 0.821 rs2520343 chr7:18843808 C/A cg13420273 chr7:18810212 HDAC9 0.37 5.22 0.31 3.55e-7 Night sleep phenotypes; CESC cis rs55794721 0.509 rs2982358 chr1:25745204 G/T cg12412775 chr1:25698385 RHCE -0.29 -5.13 -0.3 5.68e-7 Plateletcrit;Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10545644 chr17:40719582 MLX -0.38 -6.11 -0.35 3.52e-9 Gambling; CESC cis rs2228479 0.850 rs17233567 chr16:89813821 G/A cg14709524 chr16:89940631 TCF25 0.95 7.1 0.4 1.18e-11 Skin colour saturation; CESC cis rs9486715 0.867 rs7451950 chr6:96879974 T/C cg18709589 chr6:96969512 KIAA0776 0.45 6.46 0.37 5.05e-10 Headache; CESC cis rs698813 0.674 rs11680456 chr2:44497544 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.34 0.31 2e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2486288 0.656 rs10519018 chr15:45549265 C/T cg21132104 chr15:45694354 SPATA5L1 -0.55 -6.71 -0.38 1.2e-10 Glomerular filtration rate; CESC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg06221963 chr1:154839813 KCNN3 -0.66 -11.12 -0.56 8.2e-24 Prostate cancer; CESC cis rs17384381 1.000 rs12123745 chr1:85884772 T/C cg16011679 chr1:85725395 C1orf52 0.74 7.58 0.42 5.98e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs911555 0.755 rs9671414 chr14:103967299 C/T cg09975044 chr14:104007538 NA -0.47 -5.53 -0.32 7.53e-8 Intelligence (multi-trait analysis); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg09140281 chr5:131563492 P4HA2 0.52 6.41 0.37 6.66e-10 Psoriatic arthritis; CESC cis rs34779708 0.966 rs2045915 chr10:35418616 G/C cg03585969 chr10:35415529 CREM 0.77 10.03 0.52 2.75e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs2072499 0.865 rs2758608 chr1:156202860 A/T cg25208724 chr1:156163844 SLC25A44 0.84 13.27 0.63 3.75e-31 Testicular germ cell tumor; CESC cis rs1697139 0.583 rs17289614 chr5:66541592 G/A cg11553311 chr5:66541588 NA 0.38 5.37 0.31 1.75e-7 Breast cancer; CESC cis rs10411936 1.000 rs10411936 chr19:16548375 C/T cg10248733 chr19:16607483 C19orf44;CALR3 -0.5 -6.02 -0.35 5.81e-9 White blood cell count;Multiple sclerosis; CESC cis rs3820068 0.608 rs58140482 chr1:16043979 A/G cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.35 4.28e-9 Systolic blood pressure; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06471548 chr7:192006 FAM20C -0.5 -6.74 -0.38 9.92e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4253772 0.938 rs10154348 chr22:46638159 C/A cg00784671 chr22:46762841 CELSR1 -0.51 -5.27 -0.31 2.87e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4836694 0.574 rs67899211 chr9:132935614 G/A cg05251000 chr9:132935664 FREQ 0.43 5.68 0.33 3.47e-8 Alzheimer's disease (cognitive decline); CESC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg11247378 chr22:39784982 NA -0.64 -9.68 -0.51 3.5e-19 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.74e-9 Prudent dietary pattern; CESC cis rs7965445 0.803 rs61937080 chr12:131929054 C/A cg08164151 chr12:131118432 NA 0.63 5.15 0.3 5.11e-7 Mortality in heart failure; CESC cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs1784581 0.588 rs9885762 chr6:162411954 G/A cg17173639 chr6:162384350 PARK2 0.58 8.71 0.47 3.3e-16 Itch intensity from mosquito bite; CESC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg14789911 chr21:47582049 C21orf56 0.35 5.18 0.3 4.36e-7 Testicular germ cell tumor; CESC cis rs67478160 0.619 rs1187416 chr14:104311465 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.18 -0.4 7.24e-12 Schizophrenia; CESC cis rs8067354 0.645 rs2102507 chr17:57875907 A/G cg13753209 chr17:57696993 CLTC 0.66 8.34 0.46 4.12e-15 Hemoglobin concentration; CESC cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg03467027 chr4:99064603 C4orf37 0.44 5.37 0.31 1.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs698813 0.572 rs13424464 chr2:44482263 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.41 0.32 1.41e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs637571 0.522 rs542332 chr11:65744421 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 6.05 0.35 5.01e-9 Eosinophil percentage of white cells; CESC cis rs7772486 0.686 rs9485019 chr6:146046381 C/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.99 -0.39 2.21e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7267979 0.933 rs11699203 chr20:25435169 G/C cg08601574 chr20:25228251 PYGB 0.37 5.31 0.31 2.31e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7605827 0.930 rs12692267 chr2:15572834 A/G cg19274914 chr2:15703543 NA -0.32 -5.93 -0.34 9.24e-9 Educational attainment (years of education); CESC cis rs473651 1.000 rs473651 chr2:239335401 A/C cg18131467 chr2:239335373 ASB1 1.04 20.93 0.79 4.5e-58 Multiple system atrophy; CESC cis rs6061231 0.561 rs67072353 chr20:60940702 G/A cg24112000 chr20:60950667 NA -0.59 -6.16 -0.35 2.66e-9 Colorectal cancer; CESC trans rs7178375 0.941 rs4779796 chr15:31208050 C/T cg04373760 chr16:53404718 NA 0.53 7.2 0.4 6.18e-12 Hypertriglyceridemia; CESC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg14893161 chr1:205819251 PM20D1 -0.47 -6.47 -0.37 4.7e-10 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs1387259 0.929 rs11168460 chr12:48597365 A/G cg04545296 chr12:48745243 ZNF641 0.4 6.74 0.38 9.66e-11 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs17253792 0.822 rs28481586 chr14:56053863 C/G cg01858014 chr14:56050164 KTN1 -0.82 -6.45 -0.37 5.37e-10 Putamen volume; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg08946332 chr17:6899888 ALOX12 0.44 6.43 0.37 5.99e-10 Tonsillectomy; CESC cis rs4803468 0.967 rs13344547 chr19:41945848 G/T cg14132834 chr19:41945861 ATP5SL 0.6 7.5 0.42 9.48e-13 Height; CESC cis rs4588572 0.601 rs10942855 chr5:77737529 G/A cg11547950 chr5:77652471 NA -0.44 -5.54 -0.32 7.21e-8 Triglycerides; CESC cis rs6582630 0.555 rs7969922 chr12:38529491 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.95 0.34 8.41e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7586673 0.857 rs16845580 chr2:161920884 T/C cg08807892 chr2:162101083 NA 0.45 6.1 0.35 3.83e-9 Intelligence (multi-trait analysis); CESC cis rs7267979 1.000 rs2257982 chr20:25269630 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs709400 0.526 rs11622835 chr14:103967504 G/A cg12935359 chr14:103987150 CKB -0.63 -6.89 -0.39 4.02e-11 Body mass index; CESC cis rs12618769 0.597 rs3769737 chr2:99088873 C/G cg10123293 chr2:99228465 UNC50 -0.39 -5.13 -0.3 5.6e-7 Bipolar disorder; CESC trans rs10743315 0.643 rs75189071 chr12:19329505 C/T cg09562322 chr12:119419143 SRRM4 -0.49 -6.18 -0.35 2.45e-9 Gut microbiota (bacterial taxa); CESC cis rs2243480 0.908 rs2460431 chr7:65622846 A/G cg12463550 chr7:65579703 CRCP -0.73 -5.71 -0.33 3.1e-8 Diabetic kidney disease; CESC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg21724239 chr8:58056113 NA 0.57 5.76 0.33 2.29e-8 Developmental language disorder (linguistic errors); CESC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg16145915 chr7:1198662 ZFAND2A -0.5 -6.31 -0.36 1.18e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4727963 0.869 rs10953973 chr7:122793182 T/C cg03640110 chr7:122635026 TAS2R16 0.33 5.11 0.3 6.2e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg11890956 chr21:40555474 PSMG1 -0.67 -9.42 -0.5 2.35e-18 Menarche (age at onset); CESC cis rs8060686 0.844 rs7196076 chr16:67887494 T/A cg26727032 chr16:67993705 SLC12A4 -0.55 -5.63 -0.33 4.53e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs1975974 0.872 rs66502681 chr17:21722119 T/A cg18423549 chr17:21743878 NA -0.51 -7.02 -0.4 1.81e-11 Psoriasis; CESC cis rs6500395 0.926 rs1039344 chr16:48577569 A/G cg04672837 chr16:48644449 N4BP1 0.45 5.43 0.32 1.3e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs425277 1.000 rs55826501 chr1:2059143 G/A cg04315214 chr1:2043799 PRKCZ -0.43 -5.95 -0.34 8.56e-9 Height; CESC cis rs8058578 0.832 rs3812999 chr16:30773605 G/T cg02466173 chr16:30829666 NA -0.41 -6.68 -0.38 1.43e-10 Multiple myeloma; CESC cis rs11792861 0.962 rs3829084 chr9:111801724 C/G cg14384093 chr9:111878565 C9orf5 0.42 5.26 0.31 2.93e-7 Menarche (age at onset); CESC cis rs10871290 0.881 rs3863439 chr16:74470644 T/C cg01733217 chr16:74700730 RFWD3 -0.67 -8.98 -0.48 5.28e-17 Breast cancer; CESC cis rs739401 0.611 rs401707 chr11:3050965 T/C cg08508325 chr11:3079039 CARS -0.56 -10.89 -0.56 4.52e-23 Longevity; CESC cis rs9291683 0.551 rs2276961 chr4:10022981 C/T cg00071950 chr4:10020882 SLC2A9 0.89 17.02 0.72 2.12e-44 Bone mineral density; CESC cis rs7944584 0.511 rs10838725 chr11:47557871 T/C cg10504702 chr11:47789108 FNBP4 0.42 5.2 0.3 4.01e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24429881 chr1:166809343 POGK -0.45 -6.08 -0.35 4.24e-9 Fibrinogen levels; CESC cis rs1371867 0.846 rs1692006 chr8:101252462 C/T cg11906718 chr8:101322791 RNF19A -0.45 -5.64 -0.33 4.46e-8 Atrioventricular conduction; CESC cis rs7772486 0.774 rs6930181 chr6:146180974 A/T cg23711669 chr6:146136114 FBXO30 -0.7 -10.36 -0.54 2.37e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg00684032 chr4:1343700 KIAA1530 0.41 5.72 0.33 2.95e-8 Obesity-related traits; CESC cis rs2635047 0.967 rs1119005 chr18:44725605 A/G cg19077165 chr18:44547161 KATNAL2 -0.46 -6.26 -0.36 1.54e-9 Educational attainment; CESC cis rs4927850 0.723 rs7630825 chr3:195753740 T/C cg01181863 chr3:195395398 SDHAP2 -0.55 -6.66 -0.38 1.53e-10 Pancreatic cancer; CESC cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00173170 chr1:214779122 CENPF -0.56 -6.61 -0.38 2.08e-10 Gut microbiome composition (summer); CESC cis rs34779708 0.931 rs9663401 chr10:35278849 G/T cg04310649 chr10:35416472 CREM -0.5 -5.97 -0.34 7.61e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.56 5.5 0.32 8.88e-8 Depression; CESC cis rs10504229 0.861 rs67966192 chr8:58188172 A/C cg24829409 chr8:58192753 C8orf71 -0.62 -8.61 -0.47 6.43e-16 Developmental language disorder (linguistic errors); CESC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.31e-9 Developmental language disorder (linguistic errors); CESC cis rs763014 0.898 rs8060921 chr16:635988 C/A cg00802000 chr16:706648 WDR90 -0.41 -6.19 -0.36 2.26e-9 Height; CESC cis rs7264396 0.635 rs6058375 chr20:34531997 T/A cg23207816 chr20:34252616 CPNE1;RBM12 0.55 6.67 0.38 1.53e-10 Total cholesterol levels; CESC cis rs1843834 0.539 rs12694643 chr2:225446603 A/G cg22509189 chr2:225307070 NA -0.41 -5.59 -0.32 5.63e-8 IgE levels in asthmatics (D.p. specific); CESC cis rs2928148 0.522 rs11858278 chr15:41416276 T/C cg18705301 chr15:41695430 NDUFAF1 -0.76 -9.87 -0.52 9.03e-20 Glomerular filtration rate in non diabetics (creatinine); CESC cis rs11122272 0.735 rs2739518 chr1:231537633 C/T cg06096015 chr1:231504339 EGLN1 0.42 6.07 0.35 4.33e-9 Hemoglobin concentration; CESC cis rs10242455 0.571 rs11734 chr7:99229768 C/G cg07338983 chr7:99679036 ZNF3 -0.63 -5.04 -0.3 8.69e-7 Blood metabolite levels; CESC cis rs13106227 0.576 rs10031136 chr4:77407344 A/G cg20311846 chr4:77356250 SHROOM3 -0.31 -6.04 -0.35 5.26e-9 Eosinophilic esophagitis (pediatric); CESC cis rs7208859 0.623 rs9899268 chr17:29150255 T/C cg13385521 chr17:29058706 SUZ12P 0.8 6.42 0.37 6.22e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg24675658 chr1:53192096 ZYG11B 0.53 6.68 0.38 1.43e-10 Monocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11310125 chr2:113239311 TTL -0.46 -6.57 -0.37 2.68e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg11764359 chr7:65958608 NA 0.68 8.53 0.46 1.15e-15 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23260799 chr11:451101 PTDSS2 0.54 7.0 0.4 2.08e-11 Gut microbiota (bacterial taxa); CESC cis rs9486719 1.000 rs13202675 chr6:97028427 C/T cg18709589 chr6:96969512 KIAA0776 -0.5 -5.43 -0.32 1.28e-7 Migraine;Coronary artery disease; CESC cis rs4975616 0.869 rs466502 chr5:1325767 C/T cg07493874 chr5:1342172 CLPTM1L 0.41 7.95 0.44 5.54e-14 Lung cancer; CESC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg11494091 chr17:61959527 GH2 0.74 12.57 0.61 9.52e-29 Prudent dietary pattern; CESC cis rs2066819 0.892 rs112931321 chr12:56667894 C/T cg26734620 chr12:56694298 CS 1.07 6.56 0.37 2.85e-10 Psoriasis vulgaris; CESC cis rs919433 0.889 rs787998 chr2:198216092 A/G cg10820045 chr2:198174542 NA 0.4 6.05 0.35 4.95e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs752010 0.967 rs10890153 chr1:42102060 C/A cg06885757 chr1:42089581 HIVEP3 0.5 8.07 0.44 2.49e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs2050392 0.517 rs7096279 chr10:30759608 C/T cg25182066 chr10:30743637 MAP3K8 -0.52 -7.65 -0.43 3.71e-13 Inflammatory bowel disease; CESC cis rs2235642 0.826 rs8053605 chr16:1594158 G/A cg07639376 chr16:1584516 IFT140;TMEM204 -0.32 -5.21 -0.3 3.88e-7 Coronary artery disease; CESC cis rs796364 0.950 rs56155997 chr2:200768491 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.95 -7.48 -0.42 1.09e-12 Schizophrenia; CESC cis rs6933660 0.536 rs3800274 chr6:151759192 T/G cg14262678 chr6:151773367 RMND1;C6orf211 0.58 7.19 0.4 6.66e-12 Menarche (age at onset); CESC cis rs72781680 0.846 rs72782114 chr2:24025740 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.62 0.33 4.86e-8 Lymphocyte counts; CESC cis rs11098499 0.863 rs6534139 chr4:120449456 A/G cg09307838 chr4:120376055 NA -0.91 -12.17 -0.6 2.32e-27 Corneal astigmatism; CESC cis rs11853189 0.938 rs113594982 chr15:78557392 C/T cg22935921 chr15:78556834 DNAJA4 0.61 5.1 0.3 6.35e-7 Red cell distribution width; CESC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg18446336 chr7:2847575 GNA12 -0.4 -5.75 -0.33 2.45e-8 Height; CESC cis rs7809950 0.678 rs2395868 chr7:106897500 C/T cg23024343 chr7:107201750 COG5 0.54 7.09 0.4 1.24e-11 Coronary artery disease; CESC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg00149659 chr3:10157352 C3orf10 0.61 6.61 0.38 2.1e-10 Alzheimer's disease; CESC cis rs9467711 0.516 rs1324087 chr6:25841408 A/G cg21479132 chr6:26055353 NA -0.61 -6.47 -0.37 4.69e-10 Autism spectrum disorder or schizophrenia; CESC cis rs6964587 1.000 rs12537846 chr7:91721581 C/T cg17063962 chr7:91808500 NA -0.58 -7.87 -0.44 8.99e-14 Breast cancer; CESC cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9987353 0.566 rs13260067 chr8:9071033 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -6.46 -0.37 4.99e-10 Recombination measurement; CESC cis rs7551222 0.752 rs4328119 chr1:204564986 C/T cg20240347 chr1:204465584 NA -0.26 -5.39 -0.31 1.57e-7 Schizophrenia; CESC cis rs7149337 0.805 rs2999361 chr14:51605358 G/A cg23942311 chr14:51606299 NA 0.48 8.34 0.46 4.23e-15 Cancer; CESC cis rs6912958 0.781 rs4707379 chr6:88310623 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.69 -0.38 1.35e-10 Monocyte percentage of white cells; CESC cis rs7582720 1.000 rs114393235 chr2:203795987 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs9560113 0.573 rs1888304 chr13:112242454 A/G cg10483660 chr13:112241077 NA 0.44 7.31 0.41 3.18e-12 Menarche (age at onset); CESC cis rs5753037 0.547 rs140134 chr22:30163332 G/A cg01021169 chr22:30184971 ASCC2 -0.57 -8.56 -0.47 9.24e-16 Type 1 diabetes; CESC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC trans rs1814175 0.645 rs7123448 chr11:49764865 T/G cg15704280 chr7:45808275 SEPT13 -1.0 -17.38 -0.73 1.13e-45 Height; CESC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg12463550 chr7:65579703 CRCP -0.53 -6.74 -0.38 9.87e-11 Aortic root size; CESC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg00684032 chr4:1343700 KIAA1530 0.35 5.45 0.32 1.17e-7 Longevity; CESC cis rs8103278 0.507 rs62111759 chr19:46296230 A/T cg20908204 chr19:46285434 DMPK 0.35 5.58 0.32 6.09e-8 Coronary artery disease; CESC cis rs698833 0.780 rs11124986 chr2:44508835 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.52 6.61 0.38 2.11e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs2050392 0.624 rs303447 chr10:30728464 T/C cg25182066 chr10:30743637 MAP3K8 -0.45 -5.91 -0.34 1.04e-8 Inflammatory bowel disease; CESC cis rs763014 0.931 rs3752568 chr16:628302 A/G cg09263875 chr16:632152 PIGQ 0.67 11.07 0.56 1.14e-23 Height; CESC trans rs1814175 0.935 rs7479914 chr11:49661351 T/C cg03929089 chr4:120376271 NA -0.87 -13.36 -0.63 1.83e-31 Height; CESC cis rs7927771 1.000 rs4752856 chr11:47648042 C/T cg05585544 chr11:47624801 NA -0.53 -8.38 -0.46 3.1e-15 Subjective well-being; CESC cis rs4919044 0.808 rs835256 chr10:94779550 C/T cg26979504 chr10:94451518 HHEX -0.47 -5.15 -0.3 5.16e-7 Coronary artery disease; CESC cis rs2180341 1.000 rs6569477 chr6:127589302 T/A cg24812749 chr6:127587940 RNF146 1.06 15.28 0.68 3.03e-38 Breast cancer; CESC cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg10523679 chr1:76189770 ACADM 0.7 8.12 0.45 1.73e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1008375 0.932 rs13109475 chr4:17677565 C/G cg16339924 chr4:17578868 LAP3 -0.57 -6.87 -0.39 4.5e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg11764359 chr7:65958608 NA 0.8 11.64 0.58 1.39e-25 Aortic root size; CESC cis rs3845702 0.736 rs12693214 chr2:180825685 G/A cg01881094 chr2:180872142 CWC22 -1.06 -9.19 -0.49 1.18e-17 Schizophrenia; CESC cis rs2279817 1.000 rs2354290 chr1:18019861 A/G cg21791023 chr1:18019539 ARHGEF10L 0.55 8.17 0.45 1.27e-14 Neuroticism; CESC cis rs5758659 0.652 rs133305 chr22:42395960 C/T cg04733989 chr22:42467013 NAGA 0.44 5.81 0.34 1.78e-8 Cognitive function; CESC cis rs6973256 0.569 rs6944149 chr7:133381365 A/C cg10665199 chr7:133106180 EXOC4 0.45 6.11 0.35 3.54e-9 Intelligence (multi-trait analysis); CESC cis rs9926296 0.632 rs4785717 chr16:89801133 A/G cg04287289 chr16:89883240 FANCA 0.65 8.79 0.48 1.88e-16 Vitiligo; CESC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg08736216 chr1:53307985 ZYG11A 0.4 6.45 0.37 5.35e-10 Monocyte count; CESC cis rs9487051 0.837 rs2356817 chr6:109642675 G/A cg12927641 chr6:109611667 NA -0.4 -5.92 -0.34 1e-8 Reticulocyte fraction of red cells; CESC cis rs6460942 1.000 rs6460938 chr7:12406808 T/G cg06484146 chr7:12443880 VWDE -0.8 -9.02 -0.48 3.94e-17 Coronary artery disease; CESC cis rs10242455 0.867 rs1818797 chr7:99296195 G/A cg07715041 chr7:99302981 CYP3A7 -0.44 -5.56 -0.32 6.73e-8 Blood metabolite levels; CESC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg22433210 chr17:43662623 NA -0.91 -10.49 -0.54 9.15e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2882667 0.754 rs11746434 chr5:138435303 A/G cg04439458 chr5:138467593 SIL1 -0.41 -6.37 -0.36 8.13e-10 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08317834 chr8:26148868 PPP2R2A 0.55 6.84 0.39 5.51e-11 Gut microbiome composition (summer); CESC cis rs17001868 0.568 rs55769635 chr22:40790101 G/A cg07138101 chr22:40742427 ADSL 0.52 5.32 0.31 2.17e-7 Mammographic density (dense area); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14093289 chr19:33622866 WDR88 -0.5 -6.36 -0.36 8.66e-10 Asthma; CESC cis rs4319547 0.915 rs7316734 chr12:123117425 A/G cg05707623 chr12:122985044 ZCCHC8 -0.59 -6.95 -0.39 2.76e-11 Body mass index; CESC trans rs3008870 0.583 rs2031495 chr1:67421714 G/T cg19754094 chr2:74055942 STAMBP 0.62 6.0 0.35 6.49e-9 Lymphocyte percentage of white cells; CESC cis rs9488822 0.636 rs11153592 chr6:116330574 T/C cg26893134 chr6:116381904 FRK 0.25 6.0 0.35 6.32e-9 Cholesterol, total;LDL cholesterol; CESC cis rs9583531 0.600 rs7986286 chr13:111357207 A/G cg15841412 chr13:111365552 ING1 0.5 6.51 0.37 3.78e-10 Coronary artery disease; CESC cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.65 7.85 0.43 1.05e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs11190604 1.000 rs2489047 chr10:102347028 A/G cg07080220 chr10:102295463 HIF1AN 0.52 5.07 0.3 7.52e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs6693567 0.565 rs4926395 chr1:150405298 T/C cg09579323 chr1:150459698 TARS2 0.46 5.89 0.34 1.15e-8 Migraine; CESC cis rs1372520 0.564 rs356197 chr4:90682750 G/A cg15133208 chr4:90757351 SNCA 0.43 5.12 0.3 5.78e-7 Neuroticism; CESC cis rs9486715 1.000 rs2273621 chr6:97058553 A/G cg18709589 chr6:96969512 KIAA0776 -0.46 -6.33 -0.36 1.04e-9 Headache; CESC cis rs2404602 0.684 rs11072600 chr15:76867915 T/C cg23625390 chr15:77176239 SCAPER -0.44 -6.14 -0.35 3.01e-9 Blood metabolite levels; CESC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.15 0.4 8.44e-12 Electroencephalogram traits; CESC cis rs13096760 1 rs13096760 chr3:49476806 T/C cg06212747 chr3:49208901 KLHDC8B 0.49 6.7 0.38 1.21e-10 Intelligence (multi-trait analysis); CESC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.02e-11 Tonsillectomy; CESC cis rs644799 0.544 rs1254935 chr11:95631470 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.52 6.69 0.38 1.29e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6121246 0.609 rs6060843 chr20:30297047 G/C cg13852791 chr20:30311386 BCL2L1 0.82 10.57 0.54 5.11e-22 Mean corpuscular hemoglobin; CESC cis rs2295499 0.643 rs3733215 chr4:2698364 C/T cg08330972 chr4:2403930 ZFYVE28 -0.31 -5.1 -0.3 6.62e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg12927641 chr6:109611667 NA -0.43 -6.75 -0.38 9.5e-11 Reticulocyte fraction of red cells; CESC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg18876405 chr7:65276391 NA 0.5 5.81 0.34 1.75e-8 Aortic root size; CESC cis rs17376456 0.825 rs17372649 chr5:93126096 C/G cg25358565 chr5:93447407 FAM172A 1.11 10.66 0.55 2.6e-22 Diabetic retinopathy; CESC cis rs1728785 0.901 rs1728787 chr16:68593042 G/C cg02972257 chr16:68554789 NA -0.59 -6.7 -0.38 1.23e-10 Ulcerative colitis; CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg01238044 chr22:24384105 GSTT1 0.74 10.18 0.53 8.97e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs561341 0.941 rs7215147 chr17:30266711 G/A cg27661571 chr11:113659931 NA -0.57 -6.42 -0.37 6.14e-10 Hip circumference adjusted for BMI; CESC cis rs561341 0.825 rs2008368 chr17:30347397 T/C cg12193833 chr17:30244370 NA -0.73 -6.51 -0.37 3.83e-10 Hip circumference adjusted for BMI; CESC cis rs9902453 0.967 rs12602258 chr17:28317657 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 8.08 0.44 2.36e-14 Coffee consumption (cups per day); CESC cis rs11122272 0.735 rs2790892 chr1:231512771 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs79349575 0.679 rs9894239 chr17:46997959 C/T cg16584676 chr17:46985605 UBE2Z -0.71 -9.25 -0.49 8.03e-18 Type 2 diabetes; CESC trans rs10488821 0.953 rs1458727 chr11:30517996 C/T cg04407762 chr4:113442791 NA -0.45 -6.61 -0.38 2.07e-10 QRS complex (12-leadsum); CESC cis rs7546094 0.967 rs1032312 chr1:113112746 G/A cg22162597 chr1:113214053 CAPZA1 0.37 5.67 0.33 3.69e-8 Platelet distribution width; CESC trans rs1459104 0.778 rs12797173 chr11:55506548 C/T cg10201141 chr12:7032793 ENO2;ATN1 -0.74 -6.46 -0.37 4.88e-10 Body mass index; CESC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg12379764 chr21:47803548 PCNT 0.47 6.04 0.35 5.07e-9 Testicular germ cell tumor; CESC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg23161317 chr6:28129485 ZNF389 0.51 6.32 0.36 1.08e-9 Parkinson's disease; CESC cis rs8114671 0.869 rs66535333 chr20:33656666 G/A cg24642439 chr20:33292090 TP53INP2 -0.47 -5.7 -0.33 3.19e-8 Height; CESC cis rs9486719 0.741 rs976356 chr6:96849437 T/A cg06623918 chr6:96969491 KIAA0776 0.77 7.27 0.41 4.05e-12 Migraine;Coronary artery disease; CESC cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26447919 chr20:17949531 C20orf72;SNX5 0.56 6.47 0.37 4.61e-10 Gut microbiome composition (summer); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg27434890 chr6:135517041 MYB 0.4 6.23 0.36 1.81e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 11.71 0.58 8.43e-26 Platelet count; CESC cis rs8062405 1.000 rs11861174 chr16:28871989 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7660520 0.524 rs4862101 chr4:183733177 T/C cg04181038 chr4:183730758 NA 0.64 6.96 0.39 2.71e-11 Pediatric autoimmune diseases; CESC cis rs763121 0.853 rs1569492 chr22:38975511 A/G cg06022373 chr22:39101656 GTPBP1 -0.72 -11.35 -0.57 1.39e-24 Menopause (age at onset); CESC cis rs734999 0.545 rs12730932 chr1:2559589 T/G cg18854424 chr1:2615690 NA -0.3 -5.88 -0.34 1.2e-8 Ulcerative colitis; CESC cis rs9733 0.744 rs11204725 chr1:150742700 T/C cg22823121 chr1:150693482 HORMAD1 -0.39 -5.83 -0.34 1.63e-8 Tonsillectomy; CESC cis rs2439831 1.000 rs690436 chr15:43761205 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.85 12.48 0.61 1.94e-28 Lung cancer in ever smokers; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27152661 chr10:99052555 ARHGAP19 -0.48 -6.63 -0.38 1.84e-10 Gut microbiota (bacterial taxa); CESC cis rs2066819 1.000 rs78121408 chr12:56684798 C/T cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27135125 chr7:23510082 IGF2BP3 0.56 6.41 0.37 6.8e-10 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg17949981 chr6:28129498 ZNF389 0.49 6.18 0.35 2.4e-9 Depression; CESC cis rs2228479 0.557 rs62054639 chr16:89821489 C/T cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg18876405 chr7:65276391 NA 0.47 5.71 0.33 3.05e-8 Aortic root size; CESC cis rs4417704 0.551 rs6753109 chr2:241877597 C/T cg05025159 chr2:241905733 NA -0.35 -5.18 -0.3 4.39e-7 Joint mobility (Beighton score); CESC cis rs752010 1.000 rs4999015 chr1:42093547 G/A cg06885757 chr1:42089581 HIVEP3 0.5 8.22 0.45 9.25e-15 Lupus nephritis in systemic lupus erythematosus; CESC cis rs1915146 0.546 rs2681919 chr10:126859029 A/G cg05090351 chr10:126851162 NA 0.6 9.24 0.49 8.52e-18 Menarche (age at onset); CESC cis rs2963155 0.518 rs72801054 chr5:142687742 T/C cg17617527 chr5:142782415 NR3C1 0.79 6.76 0.38 8.65e-11 Breast cancer; CESC cis rs6430585 0.583 rs12472293 chr2:136648077 T/C cg07169764 chr2:136633963 MCM6 1.3 20.37 0.78 3.82e-56 Corneal structure; CESC cis rs763121 0.925 rs9611008 chr22:39098787 T/C cg21395723 chr22:39101663 GTPBP1 0.44 5.89 0.34 1.19e-8 Menopause (age at onset); CESC cis rs3780486 0.522 rs1328898 chr9:33163271 A/G cg13443165 chr9:33130375 B4GALT1 0.48 7.29 0.41 3.61e-12 IgG glycosylation; CESC cis rs10129255 0.719 rs7156660 chr14:107129187 T/C cg07958169 chr14:107095056 NA -0.41 -6.01 -0.35 6.26e-9 Kawasaki disease; CESC cis rs12079745 0.793 rs12074013 chr1:169133621 C/T cg09363564 chr1:169337483 NME7;BLZF1 -1.07 -6.67 -0.38 1.52e-10 QT interval; CESC cis rs7680126 0.596 rs12503603 chr4:10313757 T/G cg11266682 chr4:10021025 SLC2A9 -0.43 -5.29 -0.31 2.54e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs7474896 0.583 rs12783272 chr10:38024885 T/G cg00409905 chr10:38381863 ZNF37A -0.48 -5.2 -0.3 4.06e-7 Obesity (extreme); CESC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.81 0.34 1.79e-8 Intelligence (multi-trait analysis); CESC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg13628971 chr7:2884303 GNA12 0.64 8.03 0.44 3.22e-14 Height; CESC cis rs922182 0.599 rs34409256 chr15:64270314 G/T cg24729988 chr15:64271149 DAPK2 -0.48 -6.86 -0.39 4.91e-11 Blood protein levels; CESC cis rs9287719 0.967 rs7592691 chr2:10737426 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs2952156 0.920 rs2952152 chr17:37832735 T/C cg20243544 chr17:37824526 PNMT 0.62 7.95 0.44 5.42e-14 Asthma; CESC cis rs4728302 0.869 rs6966403 chr7:133614421 A/C cg10665199 chr7:133106180 EXOC4 -0.39 -5.35 -0.31 1.87e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs34779708 0.966 rs4934735 chr10:35496730 C/T cg04310649 chr10:35416472 CREM 0.49 5.91 0.34 1.07e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs4604732 0.527 rs60444724 chr1:247623164 T/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.42 5.27 0.31 2.9e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs8060686 0.516 rs2290700 chr16:68288983 T/G cg26727032 chr16:67993705 SLC12A4 -0.55 -7.2 -0.4 6.16e-12 HDL cholesterol;Metabolic syndrome; CESC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -5.9 -0.34 1.13e-8 Tonsillectomy; CESC cis rs9527 0.590 rs7920868 chr10:104795409 C/T cg04362960 chr10:104952993 NT5C2 0.42 5.44 0.32 1.24e-7 Arsenic metabolism; CESC cis rs2952156 0.920 rs907090 chr17:37833632 T/C cg00129232 chr17:37814104 STARD3 -0.74 -10.58 -0.55 4.66e-22 Asthma; CESC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg08736216 chr1:53307985 ZYG11A -0.39 -6.7 -0.38 1.23e-10 Monocyte count; CESC cis rs6893300 0.961 rs730012 chr5:179220638 A/C cg14593053 chr5:179126677 CANX -0.51 -5.66 -0.33 3.92e-8 Resting heart rate; CESC cis rs847577 0.677 rs951988 chr7:97762474 C/G cg21770322 chr7:97807741 LMTK2 -0.5 -7.3 -0.41 3.36e-12 Breast cancer; CESC cis rs2797685 0.755 rs41402249 chr1:7822723 C/G cg04725166 chr1:7887271 PER3 0.45 5.21 0.3 3.84e-7 Crohn's disease; CESC cis rs9796 0.636 rs1983400 chr15:41373029 T/C cg12426344 chr15:41135900 SPINT1 -0.23 -5.1 -0.3 6.45e-7 Menopause (age at onset); CESC cis rs6121246 0.567 rs6058197 chr20:30194899 A/G cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg00376283 chr12:123451042 ABCB9 0.78 11.46 0.58 5.84e-25 Platelet count; CESC cis rs662064 0.962 rs607941 chr1:10539543 C/T cg20482658 chr1:10539492 PEX14 -0.42 -8.64 -0.47 5.55e-16 Asthma; CESC cis rs10851478 0.590 rs12591300 chr15:49704741 A/G cg08060515 chr15:49448048 GALK2;COPS2 -0.56 -7.09 -0.4 1.18e-11 Oral cavity cancer; CESC cis rs4906332 1.000 rs35224956 chr14:103900481 A/G cg09975044 chr14:104007538 NA 0.47 6.49 0.37 4.16e-10 Coronary artery disease; CESC cis rs7851660 0.844 rs12342417 chr9:100639065 G/A cg13688889 chr9:100608707 NA -0.61 -8.69 -0.47 3.77e-16 Strep throat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20138264 chr17:48585640 MYCBPAP -0.6 -6.83 -0.39 5.83e-11 Gut microbiome composition (summer); CESC cis rs761746 0.882 rs4820978 chr22:31912119 G/A cg25791279 chr22:32026902 PISD -0.49 -5.52 -0.32 7.93e-8 Intelligence; CESC cis rs2228479 0.850 rs62056063 chr16:89903680 C/T cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs910316 0.737 rs108621 chr14:75480637 T/C cg11812906 chr14:75593930 NEK9 -0.79 -12.68 -0.61 4.02e-29 Height; CESC cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg03060546 chr3:49711283 APEH 0.45 5.46 0.32 1.08e-7 Parkinson's disease; CESC cis rs10256972 0.527 rs2949170 chr7:1216438 A/G cg23978390 chr7:1156363 C7orf50 0.58 7.68 0.43 3.12e-13 Longevity;Endometriosis; CESC cis rs472109 0.565 rs441293 chr11:9786136 T/C cg03108697 chr11:9732066 SWAP70 -0.36 -5.15 -0.3 5.18e-7 Coronary artery disease; CESC cis rs9311474 0.713 rs352165 chr3:52242902 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.26 0.31 2.93e-7 Electroencephalogram traits; CESC cis rs7937682 0.961 rs552387 chr11:111490047 T/G cg22437258 chr11:111473054 SIK2 0.72 9.81 0.52 1.37e-19 Primary sclerosing cholangitis; CESC cis rs2573652 0.657 rs2573668 chr15:100541776 C/T cg00587665 chr15:100533223 ADAMTS17 0.35 5.48 0.32 1.01e-7 Height; CESC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg12463550 chr7:65579703 CRCP -0.49 -6.21 -0.36 2.06e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04779640 chr3:108307951 DZIP3;KIAA1524 -0.55 -6.75 -0.38 9.56e-11 Gut microbiome composition (summer); CESC cis rs2806561 0.734 rs7548692 chr1:23354877 T/A cg12483005 chr1:23474871 LUZP1 0.35 5.29 0.31 2.58e-7 Height; CESC cis rs2408955 0.521 rs1476607 chr12:48524804 A/G cg04545296 chr12:48745243 ZNF641 -0.36 -6.19 -0.36 2.27e-9 Glycated hemoglobin levels; CESC cis rs524023 0.874 rs7102344 chr11:64396569 A/T cg07220939 chr11:64358617 SLC22A12 -0.36 -5.45 -0.32 1.17e-7 Urate levels in obese individuals; CESC cis rs10791097 0.690 rs12284487 chr11:130729705 T/C cg09137382 chr11:130731461 NA 0.39 5.69 0.33 3.36e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.65 0.47 4.88e-16 Menopause (age at onset); CESC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg07677032 chr17:61819896 STRADA 0.45 5.69 0.33 3.36e-8 Height; CESC cis rs7301826 0.651 rs1554807 chr12:131280417 C/T cg11011512 chr12:131303247 STX2 -0.5 -6.15 -0.35 2.88e-9 Plasma plasminogen activator levels; CESC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs6032067 0.929 rs56168207 chr20:43803971 C/T cg11264863 chr20:43835661 SEMG1 0.51 5.58 0.32 5.85e-8 Blood protein levels; CESC trans rs11098499 0.863 rs13140391 chr4:120503437 A/G cg25214090 chr10:38739885 LOC399744 0.66 8.85 0.48 1.28e-16 Corneal astigmatism; CESC cis rs6088580 0.634 rs6087580 chr20:32992592 A/G cg06115741 chr20:33292138 TP53INP2 -0.49 -6.42 -0.37 6.13e-10 Glomerular filtration rate (creatinine); CESC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.28 -0.31 2.72e-7 Developmental language disorder (linguistic errors); CESC cis rs6537837 1.000 rs3525 chr1:110136846 T/A cg05049280 chr1:110155535 GNAT2 0.38 5.3 0.31 2.42e-7 Major depressive disorder; CESC cis rs2635047 0.967 rs9960264 chr18:44606996 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.56 7.64 0.42 3.98e-13 Educational attainment; CESC cis rs2228479 0.850 rs3785281 chr16:89824263 G/C cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.34e-11 Skin colour saturation; CESC cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg10523679 chr1:76189770 ACADM 0.55 6.21 0.36 2.04e-9 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12475106 chr4:503275 PIGG -0.68 -7.59 -0.42 5.63e-13 Gut microbiome composition (summer); CESC cis rs4604732 0.631 rs11490199 chr1:247625737 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12530845 0.945 rs73725433 chr7:135313251 C/T cg23117316 chr7:135346802 PL-5283 -0.44 -5.6 -0.33 5.48e-8 Red blood cell traits; CESC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg00339695 chr16:24857497 SLC5A11 -0.5 -6.57 -0.37 2.58e-10 Intelligence (multi-trait analysis); CESC cis rs11264213 0.901 rs631202 chr1:36449099 G/C cg27506609 chr1:36549197 TEKT2 0.49 5.19 0.3 4.1e-7 Schizophrenia; CESC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.62 -0.38 1.93e-10 Depression; CESC cis rs4594175 0.926 rs4349056 chr14:51625819 A/G cg23942311 chr14:51606299 NA 0.39 5.9 0.34 1.1e-8 Cancer; CESC cis rs9911578 1.000 rs12453459 chr17:56624291 C/T cg12560992 chr17:57184187 TRIM37 -0.93 -15.59 -0.69 2.43e-39 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19268579 chr10:43904406 HNRNPF -0.48 -6.81 -0.39 6.65e-11 Fibrinogen levels; CESC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg00815214 chr21:47717953 NA -0.48 -6.6 -0.38 2.17e-10 Testicular germ cell tumor; CESC trans rs1814175 0.645 rs1722000 chr11:49917928 A/C cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09912005 chr4:123300640 ADAD1 0.5 6.61 0.38 2.07e-10 Fibrinogen levels; CESC trans rs970548 0.657 rs11239572 chr10:46088061 C/T cg16175941 chr6:154779103 CNKSR3 -0.56 -6.52 -0.37 3.59e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CESC cis rs2012796 1.000 rs10450939 chr14:81825202 A/T cg02996355 chr14:81879375 NA 0.5 5.86 0.34 1.34e-8 Night sleep phenotypes; CESC cis rs1003719 0.708 rs3787788 chr21:38502804 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.47 -0.46 1.69e-15 Eye color traits; CESC cis rs3771570 1.000 rs59536819 chr2:242272388 A/G cg21155796 chr2:242212141 HDLBP 0.6 5.04 0.3 8.44e-7 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14036097 chr4:190862158 FRG1 0.57 6.89 0.39 3.94e-11 Gut microbiome composition (summer); CESC cis rs10918270 1.000 rs10918270 chr1:161915501 G/A cg19735514 chr1:161762739 ATF6 -0.37 -5.35 -0.31 1.94e-7 Parkinson's disease (age of onset); CESC cis rs9322193 0.962 rs2275046 chr6:150157001 A/G cg13206674 chr6:150067644 NUP43 0.42 5.81 0.34 1.8e-8 Lung cancer; CESC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg20712883 chr12:51590929 POU6F1 0.47 5.57 0.32 6.33e-8 Cisplatin-induced ototoxicity; CESC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg17724175 chr1:150552817 MCL1 0.38 5.9 0.34 1.13e-8 Melanoma; CESC cis rs2294693 0.947 rs10456496 chr6:40988840 A/G cg14769373 chr6:40998127 UNC5CL 0.4 5.91 0.34 1.02e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs9287719 0.967 rs7570118 chr2:10718007 G/T cg00105475 chr2:10696890 NA 0.4 5.79 0.33 2.02e-8 Prostate cancer; CESC trans rs61931739 0.500 rs34080094 chr12:34547952 G/A cg13010199 chr12:38710504 ALG10B 0.5 6.51 0.37 3.79e-10 Morning vs. evening chronotype; CESC cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.62 -7.25 -0.41 4.71e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1185460 0.967 rs1177563 chr11:118949083 C/T cg01677386 chr11:118938358 VPS11 -0.43 -5.56 -0.32 6.57e-8 Coronary artery disease; CESC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg09365446 chr1:150670422 GOLPH3L 0.4 5.26 0.31 3.03e-7 Melanoma; CESC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg08859206 chr1:53392774 SCP2 -0.64 -8.55 -0.47 9.9e-16 Monocyte count; CESC cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg21573476 chr21:45109991 RRP1B -0.54 -8.07 -0.44 2.41e-14 Mean corpuscular volume; CESC cis rs6752107 1.000 rs12994971 chr2:234178453 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.47 6.36 0.36 8.89e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs7680126 0.596 rs4698009 chr4:10284993 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -5.15 -0.3 5.14e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg00745463 chr17:30367425 LRRC37B -0.85 -7.68 -0.43 3.12e-13 Hip circumference adjusted for BMI; CESC cis rs6686643 0.762 rs9333432 chr1:165611159 A/G cg19407955 chr1:165599744 MGST3 -0.54 -5.68 -0.33 3.55e-8 Total ventricular volume; CESC cis rs2073300 1.000 rs74273799 chr20:23444492 T/C cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9921222 0.509 rs3743883 chr16:404750 T/C cg10349874 chr16:420996 TMEM8A;MRPL28 -0.38 -5.21 -0.3 3.79e-7 Bone mineral density (spine);Bone mineral density; CESC trans rs427691 0.625 rs845733 chr5:109023401 A/G cg00054525 chr16:88717587 CYBA -0.58 -6.37 -0.36 8.16e-10 Autism spectrum disorder or schizophrenia; CESC cis rs8077577 0.895 rs62072465 chr17:18114494 C/G cg16794390 chr17:18148240 FLII 0.41 5.63 0.33 4.55e-8 Obesity-related traits; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06821919 chr20:16710653 SNRPB2 -0.5 -6.62 -0.38 2.01e-10 Ulcerative colitis; CESC cis rs10905065 0.766 rs11598374 chr10:5826986 T/C cg11519256 chr10:5708881 ASB13 -0.39 -5.15 -0.3 4.97e-7 Menopause (age at onset); CESC cis rs3092073 0.669 rs11697323 chr20:44551579 C/T cg00125455 chr20:44574271 PCIF1 0.38 6.06 0.35 4.7e-9 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25094149 chr1:32253906 NA -0.61 -7.54 -0.42 7.61e-13 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs4660318 chr1:46334876 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12142240 0.698 rs6667861 chr1:46815749 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs8141529 0.636 rs5762799 chr22:29187380 G/T cg02153584 chr22:29168773 CCDC117 0.47 5.13 0.3 5.59e-7 Lymphocyte counts; CESC cis rs7822232 1.000 rs7822232 chr8:145145687 A/C cg06495924 chr8:145149574 CYC1 -0.83 -7.44 -0.42 1.42e-12 Blood metabolite levels; CESC cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg13628971 chr7:2884303 GNA12 0.39 5.11 0.3 6.31e-7 Height; CESC cis rs11677416 1.000 rs1516789 chr2:113531024 C/T cg27083787 chr2:113543245 IL1A 0.5 6.28 0.36 1.35e-9 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs7107174 0.901 rs11237487 chr11:78126754 G/C cg02023728 chr11:77925099 USP35 0.44 5.64 0.33 4.28e-8 Testicular germ cell tumor; CESC cis rs4319547 0.956 rs10744275 chr12:123048618 A/G cg23029597 chr12:123009494 RSRC2 -0.51 -5.44 -0.32 1.22e-7 Body mass index; CESC cis rs17376456 0.877 rs10076052 chr5:93317762 C/T cg25358565 chr5:93447407 FAM172A 1.07 10.61 0.55 3.7e-22 Diabetic retinopathy; CESC cis rs3733585 0.638 rs6414766 chr4:9956474 G/A cg00071950 chr4:10020882 SLC2A9 -0.7 -11.45 -0.58 6.33e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11711311 1.000 rs12637066 chr3:113527574 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.17 0.53 1.02e-20 IgG glycosylation; CESC cis rs3087591 1.000 rs2051506 chr17:29699860 T/A cg24425628 chr17:29625626 OMG;NF1 -0.46 -5.86 -0.34 1.38e-8 Hip circumference; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08355537 chr1:245026452 HNRNPU 0.62 6.7 0.38 1.27e-10 Gut microbiome composition (summer); CESC cis rs7274811 0.744 rs34489266 chr20:32223040 A/G cg21523528 chr20:32077966 CBFA2T2 0.64 7.44 0.42 1.41e-12 Height; CESC cis rs6580649 0.941 rs57054831 chr12:48486892 C/T cg24011408 chr12:48396354 COL2A1 -0.4 -5.04 -0.3 8.67e-7 Lung cancer; CESC trans rs12659622 0.850 rs17601883 chr5:15675883 G/A cg22457238 chr19:58570995 ZNF135 -0.51 -6.01 -0.35 6.11e-9 Obesity-related traits; CESC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg22800045 chr5:56110881 MAP3K1 0.84 10.35 0.54 2.56e-21 Initial pursuit acceleration; CESC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg13395646 chr4:1353034 KIAA1530 0.46 5.98 0.35 7.03e-9 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26316544 chr3:52188418 WDR51A -0.47 -6.51 -0.37 3.82e-10 Fibrinogen levels; CESC cis rs72634258 0.945 rs17523802 chr1:8021740 G/A cg00042356 chr1:8021962 PARK7 0.71 6.91 0.39 3.59e-11 Inflammatory bowel disease; CESC cis rs3768617 0.510 rs10797835 chr1:183072908 T/C ch.1.3577855R chr1:183094577 LAMC1 0.88 14.27 0.66 1.19e-34 Fuchs's corneal dystrophy; CESC cis rs7089973 0.604 rs2420069 chr10:116605103 A/G cg25233709 chr10:116636983 FAM160B1 0.38 6.08 0.35 4.13e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs10870270 0.913 rs4880326 chr10:133745547 C/A cg26149184 chr10:133730230 NA 0.37 5.09 0.3 6.85e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2576037 0.583 rs578451 chr18:44404525 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.76 12.39 0.61 3.92e-28 Personality dimensions; CESC cis rs4919694 1.000 rs77505796 chr10:104647774 A/T cg04362960 chr10:104952993 NT5C2 0.76 6.03 0.35 5.63e-9 Arsenic metabolism; CESC cis rs1832871 0.711 rs9459918 chr6:158703604 A/C cg07165851 chr6:158734300 TULP4 0.6 6.45 0.37 5.23e-10 Height; CESC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg16405210 chr4:1374714 KIAA1530 -0.59 -8.14 -0.45 1.56e-14 Longevity; CESC cis rs7044106 0.708 rs10760113 chr9:123474050 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.85 13.79 0.65 5.58e-33 Hip circumference adjusted for BMI; CESC cis rs10129255 0.556 rs8010005 chr14:107186226 A/G cg23076370 chr14:107095027 NA -0.65 -9.62 -0.51 5.59e-19 Kawasaki disease; CESC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg12463550 chr7:65579703 CRCP 0.51 6.36 0.36 8.66e-10 Aortic root size; CESC trans rs4689592 0.513 rs3857178 chr4:7066516 G/A cg07817883 chr1:32538562 TMEM39B -0.53 -6.09 -0.35 3.89e-9 Monocyte percentage of white cells; CESC cis rs2721195 0.719 rs4925812 chr8:145808035 C/T cg15320075 chr8:145703422 NA 0.46 6.03 0.35 5.56e-9 Age at first birth; CESC cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.55 6.81 0.39 6.44e-11 Tonsillectomy; CESC cis rs9790314 0.543 rs1349352 chr3:161118486 C/T cg03342759 chr3:160939853 NMD3 -0.44 -5.71 -0.33 2.99e-8 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11333835 chr1:23495430 LUZP1 0.43 6.14 0.35 3.01e-9 Fibrinogen levels; CESC trans rs55704346 0.566 rs12509787 chr4:25385512 C/T cg01822600 chr1:245751692 KIF26B 0.43 6.26 0.36 1.55e-9 Tonsillectomy; CESC cis rs523516 0.645 rs16525 chr17:37321605 C/T cg20555674 chr17:37321631 ARL5C 0.38 6.35 0.36 9.36e-10 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26782824 chr11:82867961 PCF11 -0.56 -6.64 -0.38 1.76e-10 Gut microbiome composition (summer); CESC cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg01579765 chr21:45077557 HSF2BP -0.55 -9.22 -0.49 9.75e-18 Mean corpuscular volume; CESC cis rs75920871 0.589 rs115787357 chr11:117064506 T/G cg01368799 chr11:117014884 PAFAH1B2 -0.8 -5.72 -0.33 2.94e-8 Subjective well-being; CESC cis rs6951245 0.515 rs78461900 chr7:1007033 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.6 -5.54 -0.32 7.41e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6736093 0.965 rs4264571 chr2:112674149 T/C cg12686935 chr2:112915763 FBLN7 -0.41 -5.18 -0.3 4.49e-7 Coronary artery disease; CESC cis rs4423214 1.000 rs1044482 chr11:71155171 C/T cg05163923 chr11:71159392 DHCR7 0.88 12.71 0.62 3.28e-29 Vitamin D levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21959316 chr1:85040158 CTBS -0.48 -6.35 -0.36 9.29e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10771431 0.935 rs1988852 chr12:9372862 G/A cg00504896 chr12:9437009 LOC642846 -0.41 -5.45 -0.32 1.15e-7 Breast size; CESC cis rs6496667 0.532 rs2601207 chr15:90963542 C/G cg22089800 chr15:90895588 ZNF774 -0.43 -5.44 -0.32 1.18e-7 Rheumatoid arthritis; CESC cis rs3760982 0.585 rs67648499 chr19:44294055 G/A cg11993925 chr19:44307056 LYPD5 0.34 5.84 0.34 1.56e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs6484504 0.576 rs2616792 chr11:31324298 T/G cg14844989 chr11:31128820 NA 0.39 5.47 0.32 1.04e-7 Red blood cell count; CESC cis rs9815354 0.638 rs73073302 chr3:42029879 T/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs7408868 1.000 rs2074617 chr19:15276055 C/G cg14696996 chr19:15285081 NOTCH3 1.12 11.59 0.58 2.09e-25 Pulse pressure; CESC cis rs3916 0.955 rs2066938 chr12:121160615 A/G cg21892295 chr12:121157589 UNC119B -0.36 -5.26 -0.31 2.96e-7 Urinary metabolites (H-NMR features); CESC cis rs9858542 0.953 rs9814873 chr3:49454112 A/G cg07274523 chr3:49395745 GPX1 0.61 7.92 0.44 6.75e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs201673768 1 rs201673768 chr12:48699606 TGTTTTGTTTTG/T cg24011408 chr12:48396354 COL2A1 0.42 6.68 0.38 1.42e-10 Platelet count; CESC cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg19912559 chr1:40204330 PPIE -0.41 -6.27 -0.36 1.44e-9 Blood protein levels; CESC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg21770322 chr7:97807741 LMTK2 0.55 8.34 0.46 4.02e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg19539972 chr4:7069911 GRPEL1 -0.66 -8.23 -0.45 8.59e-15 Monocyte percentage of white cells; CESC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg22823121 chr1:150693482 HORMAD1 -0.41 -6.3 -0.36 1.24e-9 Tonsillectomy; CESC cis rs7605827 0.930 rs6723785 chr2:15688314 T/C cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg16743903 chr16:89593216 SPG7 -0.42 -5.42 -0.32 1.31e-7 Multiple myeloma (IgH translocation); CESC trans rs4332037 0.539 rs55988458 chr7:2059761 G/A cg11693508 chr17:37793320 STARD3 0.66 6.63 0.38 1.84e-10 Bipolar disorder; CESC cis rs17023223 0.537 rs61806983 chr1:119731524 G/C cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs11871801 0.517 rs10454087 chr17:40735641 C/T cg14558262 chr17:40713999 COASY 0.51 5.89 0.34 1.19e-8 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17198369 chr8:144883931 SCRIB -0.52 -6.07 -0.35 4.37e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.729 rs203320 chr22:41913477 T/C cg17376030 chr22:41985996 PMM1 0.43 5.14 0.3 5.39e-7 Vitiligo; CESC cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.54 5.08 0.3 7.08e-7 Lung cancer in ever smokers; CESC cis rs9715521 0.935 rs62301184 chr4:59836168 A/G cg11281224 chr4:60001000 NA -0.5 -6.45 -0.37 5.19e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs12750249 0.658 rs4148045 chr1:94947655 A/G cg15462887 chr11:27744049 BDNF -0.46 -6.06 -0.35 4.56e-9 IgG glycosylation; CESC cis rs6831352 0.918 rs29001202 chr4:100053782 T/A cg13256891 chr4:100009986 ADH5 -0.77 -8.49 -0.46 1.5e-15 Alcohol dependence; CESC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.81 0.34 1.74e-8 Personality dimensions; CESC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.48 -0.5 1.49e-18 Alzheimer's disease; CESC cis rs113835537 0.529 rs4542420 chr11:66277610 G/C cg22134325 chr11:66188745 NPAS4 0.36 5.66 0.33 3.82e-8 Airway imaging phenotypes; CESC cis rs7605827 0.930 rs6710456 chr2:15669939 C/T cg19274914 chr2:15703543 NA -0.32 -5.78 -0.33 2.14e-8 Educational attainment (years of education); CESC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg09365446 chr1:150670422 GOLPH3L 0.43 6.02 0.35 5.89e-9 Tonsillectomy; CESC cis rs7216064 0.953 rs58141639 chr17:65864902 C/T cg07042672 chr17:66097459 LOC651250 -0.54 -5.59 -0.32 5.61e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10823500 1.000 rs10823500 chr10:72005190 A/G cg04118878 chr10:71993077 PPA1 0.45 5.5 0.32 9.13e-8 Blood protein levels; CESC cis rs2652834 0.904 rs2937859 chr15:63366282 C/T cg05507819 chr15:63340323 TPM1 0.68 7.16 0.4 8.17e-12 HDL cholesterol; CESC cis rs7527798 0.592 rs960086 chr1:207827069 A/G cg21110645 chr1:207815933 NA -0.33 -5.87 -0.34 1.31e-8 Erythrocyte sedimentation rate; CESC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg17724175 chr1:150552817 MCL1 0.45 7.41 0.41 1.71e-12 Tonsillectomy; CESC cis rs4595586 0.505 rs12823590 chr12:39399750 A/T cg13010199 chr12:38710504 ALG10B 0.42 5.07 0.3 7.58e-7 Morning vs. evening chronotype; CESC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg07507251 chr3:52567010 NT5DC2 0.41 7.15 0.4 8.25e-12 Bipolar disorder; CESC cis rs35110281 0.667 rs9941787 chr21:45116042 A/G cg04455712 chr21:45112962 RRP1B 0.49 7.37 0.41 2.19e-12 Mean corpuscular volume; CESC cis rs425277 0.565 rs61775448 chr1:2045376 A/G cg24578937 chr1:2090814 PRKCZ -0.34 -6.01 -0.35 5.99e-9 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23469219 chr7:128116967 METTL2B -0.53 -7.01 -0.4 1.94e-11 Fibrinogen levels; CESC cis rs73001065 0.818 rs73004966 chr19:19716558 C/T cg03709012 chr19:19516395 GATAD2A 0.94 6.55 0.37 2.96e-10 LDL cholesterol; CESC cis rs77972916 0.505 rs6736400 chr2:43500804 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.61 -5.88 -0.34 1.2e-8 Granulocyte percentage of myeloid white cells; CESC cis rs6066835 0.572 rs6066804 chr20:47262322 G/A cg18078177 chr20:47281410 PREX1 0.69 5.14 0.3 5.45e-7 Multiple myeloma; CESC cis rs1801251 1.000 rs6714245 chr2:233580505 T/C cg08000102 chr2:233561755 GIGYF2 0.67 9.05 0.49 3.1e-17 Coronary artery disease; CESC cis rs7408868 1.000 rs757472 chr19:15273221 T/C cg14696996 chr19:15285081 NOTCH3 1.02 10.91 0.56 3.94e-23 Pulse pressure; CESC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg11494091 chr17:61959527 GH2 0.68 11.47 0.58 5.36e-25 Prudent dietary pattern; CESC cis rs1348850 0.626 rs1901825 chr2:178225331 A/T cg22681709 chr2:178499509 PDE11A -0.38 -5.73 -0.33 2.73e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6460942 0.511 rs13245890 chr7:12543134 A/C cg20607287 chr7:12443886 VWDE -0.7 -7.34 -0.41 2.7e-12 Coronary artery disease; CESC cis rs9925964 0.687 rs12917722 chr16:30948397 A/G cg02466173 chr16:30829666 NA 0.37 5.56 0.32 6.6e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7666738 0.716 rs9994641 chr4:99101605 C/T cg17366294 chr4:99064904 C4orf37 0.55 7.28 0.41 3.77e-12 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.623 rs7219361 chr17:29080393 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.57 0.37 2.73e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7508 0.694 rs7830490 chr8:17922414 A/G cg18067069 chr8:17937731 ASAH1 -0.4 -5.47 -0.32 1.05e-7 Atrial fibrillation; CESC cis rs9291683 0.546 rs6829727 chr4:10051672 A/C cg02734326 chr4:10020555 SLC2A9 0.44 6.14 0.35 3.03e-9 Bone mineral density; CESC cis rs67311347 1.000 rs6801185 chr3:40505060 C/T cg01475735 chr3:40494733 NA 0.44 5.68 0.33 3.47e-8 Renal cell carcinoma; CESC cis rs7100689 0.599 rs946892 chr10:82127551 C/T cg00277334 chr10:82204260 NA -0.58 -7.63 -0.42 4.2e-13 Post bronchodilator FEV1; CESC cis rs13114435 0.723 rs13148414 chr4:183817674 C/G cg00486011 chr4:183851557 NA -0.36 -5.55 -0.32 7.06e-8 Obesity-related traits; CESC cis rs8062405 0.895 rs62036658 chr16:28850371 T/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.39 -0.31 1.58e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2274273 1.000 rs7493394 chr14:55617755 A/T cg04306507 chr14:55594613 LGALS3 0.28 5.26 0.31 2.94e-7 Protein biomarker; CESC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg22920501 chr2:26401640 FAM59B -0.84 -10.28 -0.53 4.45e-21 Gut microbiome composition (summer); CESC cis rs36051895 0.659 rs62541556 chr9:5049092 G/T cg02405213 chr9:5042618 JAK2 -0.48 -5.79 -0.34 1.96e-8 Pediatric autoimmune diseases; CESC cis rs12121840 0.790 rs74120755 chr1:165520392 A/T cg16553119 chr1:165599451 MGST3 -0.45 -5.07 -0.3 7.64e-7 Interleukin-1-receptor antagonist levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11621667 chr7:39662995 RALA -0.44 -6.22 -0.36 1.96e-9 Fibrinogen levels; CESC cis rs10927875 0.619 rs1806991 chr1:16129441 T/C cg21385522 chr1:16154831 NA -0.76 -10.68 -0.55 2.15e-22 Dilated cardiomyopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00881440 chr7:2595255 C7orf27 0.52 6.07 0.35 4.42e-9 Gut microbiome composition (summer); CESC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg18402987 chr7:1209562 NA 0.75 7.76 0.43 1.88e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg15595755 chr5:1867978 NA 0.53 8.63 0.47 5.92e-16 Cardiovascular disease risk factors; CESC cis rs7208859 0.623 rs11656844 chr17:29060597 G/T cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21845580 chr12:53472882 SPRYD3 0.61 6.7 0.38 1.22e-10 Gut microbiome composition (summer); CESC cis rs10791323 0.628 rs10750543 chr11:133718467 G/A cg06766960 chr11:133703094 NA -0.35 -5.11 -0.3 6.03e-7 Childhood ear infection; CESC cis rs4843747 0.636 rs4075597 chr16:88107590 C/A cg06915872 chr16:87998081 BANP 0.46 5.47 0.32 1.07e-7 Menopause (age at onset); CESC cis rs1401999 0.690 rs6768149 chr3:183636195 T/C cg01324343 chr3:183735012 ABCC5 0.46 8.94 0.48 6.6e-17 Anterior chamber depth; CESC cis rs12586317 0.547 rs28569331 chr14:35473584 T/C cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC cis rs9640161 0.789 rs34495356 chr7:150057791 A/G cg10018233 chr7:150070692 REPIN1 0.39 5.51 0.32 8.63e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg08470875 chr2:26401718 FAM59B 0.76 8.06 0.44 2.69e-14 Gut microbiome composition (summer); CESC cis rs9612 1.000 rs1058 chr19:44268325 C/G cg08581076 chr19:44259116 C19orf61 0.5 5.87 0.34 1.27e-8 Exhaled nitric oxide output; CESC cis rs1691799 0.867 rs1168338 chr12:66759369 T/C cg16791601 chr12:66731901 HELB -0.78 -13.96 -0.65 1.46e-33 White blood cell count (basophil); CESC cis rs10484885 0.824 rs72921954 chr6:90586656 A/G cg13799429 chr6:90582589 CASP8AP2 -0.8 -7.65 -0.43 3.69e-13 QRS interval (sulfonylurea treatment interaction); CESC cis rs9287719 0.967 rs10203664 chr2:10752377 T/C cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg00129232 chr17:37814104 STARD3 -0.56 -7.49 -0.42 1.02e-12 Glomerular filtration rate (creatinine); CESC cis rs8114671 0.662 rs6088664 chr20:33551100 G/A cg24642439 chr20:33292090 TP53INP2 0.42 5.05 0.3 8.2e-7 Height; CESC cis rs965513 0.965 rs10759944 chr9:100556972 A/G cg13688889 chr9:100608707 NA -0.58 -8.26 -0.45 6.88e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs9457247 0.765 rs10455982 chr6:167448728 C/T cg07741184 chr6:167504864 NA 0.36 6.48 0.37 4.57e-10 Crohn's disease; CESC cis rs911555 0.755 rs11627446 chr14:103946450 G/C cg24130564 chr14:104152367 KLC1 -0.5 -6.55 -0.37 2.94e-10 Intelligence (multi-trait analysis); CESC cis rs7904368 0.754 rs7076955 chr10:16852781 G/A cg14835575 chr10:16859367 RSU1 0.48 5.1 0.3 6.4e-7 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs11098499 0.955 rs1551 chr4:120158500 T/G cg09307838 chr4:120376055 NA 0.87 11.52 0.58 3.6e-25 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13379827 chr1:65468782 NA 0.57 6.35 0.36 9.13e-10 Gut microbiome composition (summer); CESC cis rs113835537 0.559 rs11227498 chr11:66269714 A/G cg22134325 chr11:66188745 NPAS4 0.37 5.78 0.33 2.11e-8 Airway imaging phenotypes; CESC cis rs8044995 0.706 rs73612697 chr16:68162016 G/A cg26727032 chr16:67993705 SLC12A4 -0.49 -5.41 -0.32 1.43e-7 Schizophrenia; CESC cis rs7216064 0.954 rs9907491 chr17:65949993 G/A cg07042672 chr17:66097459 LOC651250 0.62 7.67 0.43 3.21e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1371867 0.817 rs1788179 chr8:101333345 A/G cg11906718 chr8:101322791 RNF19A 0.53 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg04166393 chr7:2884313 GNA12 0.59 6.78 0.38 7.85e-11 Height; CESC cis rs6598955 0.585 rs6659822 chr1:26626408 C/A cg19743891 chr1:26644573 UBXN11;CD52 0.35 5.12 0.3 5.89e-7 Obesity-related traits; CESC cis rs713587 0.571 rs2438679 chr2:25317653 C/T cg10045137 chr2:25383940 POMC -0.34 -5.03 -0.3 9.15e-7 Body mass index in non-asthmatics; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19222080 chr17:61523511 CYB561 -0.45 -6.22 -0.36 1.9e-9 Fibrinogen levels; CESC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.47 0.46 1.74e-15 Bipolar disorder; CESC cis rs17401966 0.931 rs1555849 chr1:10400602 G/T cg15208524 chr1:10270712 KIF1B -0.41 -5.27 -0.31 2.87e-7 Hepatocellular carcinoma; CESC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC cis rs11785400 0.793 rs4467920 chr8:143736846 C/T cg24634471 chr8:143751801 JRK 0.46 5.91 0.34 1.06e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13522835 chr17:61905166 FTSJ3;PSMC5 0.55 6.01 0.35 6.2e-9 Gut microbiome composition (summer); CESC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg24399712 chr22:39784796 NA 0.69 9.48 0.5 1.47e-18 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05062814 chr6:39083007 C6orf64 0.52 6.24 0.36 1.69e-9 Gut microbiome composition (summer); CESC cis rs7660520 0.557 rs76004373 chr4:183731011 C/G cg04181038 chr4:183730758 NA 0.63 6.91 0.39 3.55e-11 Pediatric autoimmune diseases; CESC cis rs921968 0.519 rs72966020 chr2:219642620 C/G cg02176678 chr2:219576539 TTLL4 -0.5 -8.51 -0.46 1.34e-15 Mean corpuscular hemoglobin concentration; CESC cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg12386194 chr3:101231763 SENP7 0.41 5.12 0.3 5.89e-7 Colorectal cancer; CESC cis rs6540556 0.906 rs6540554 chr1:209932297 A/T cg23920097 chr1:209922102 NA 0.35 5.24 0.31 3.25e-7 Red blood cell count; CESC cis rs5167 0.504 rs4803779 chr19:45456497 T/C cg09555818 chr19:45449301 APOC2 0.41 6.54 0.37 3.08e-10 Blood protein levels; CESC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg13607699 chr17:42295918 UBTF 0.61 7.01 0.4 1.93e-11 Total body bone mineral density; CESC cis rs911555 0.519 rs8014069 chr14:104004311 A/C cg24130564 chr14:104152367 KLC1 -0.47 -6.58 -0.37 2.52e-10 Intelligence (multi-trait analysis); CESC cis rs8078723 1.000 rs8070454 chr17:38160754 C/T cg17467752 chr17:38218738 THRA 0.69 10.55 0.54 5.78e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs2573652 0.722 rs11852383 chr15:100542765 C/T cg00587665 chr15:100533223 ADAMTS17 -0.38 -6.0 -0.35 6.3e-9 Height; CESC cis rs782590 0.967 rs6545506 chr2:55798108 A/G cg18811423 chr2:55921094 PNPT1 -0.77 -12.45 -0.61 2.48e-28 Metabolic syndrome; CESC cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg22834771 chr12:69754056 YEATS4 -0.48 -6.37 -0.36 8.22e-10 Blood protein levels; CESC cis rs9811920 0.609 rs812657 chr3:99566329 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.63 -10.36 -0.54 2.45e-21 Axial length; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18451310 chr22:42017231 PPPDE2;XRCC6 -0.68 -8.35 -0.46 3.74e-15 Gut microbiome composition (summer); CESC cis rs8077577 0.708 rs2290503 chr17:18135753 T/C cg16794390 chr17:18148240 FLII -0.45 -6.69 -0.38 1.33e-10 Obesity-related traits; CESC cis rs782590 0.620 rs4322879 chr2:55797033 G/T cg18811423 chr2:55921094 PNPT1 -0.62 -8.26 -0.45 7.09e-15 Metabolic syndrome; CESC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg03352830 chr11:487213 PTDSS2 0.76 7.2 0.4 6.21e-12 Body mass index; CESC trans rs4843747 0.749 rs13333619 chr16:88072076 C/T cg26811252 chr16:29126840 RRN3P2 0.73 10.49 0.54 9.35e-22 Menopause (age at onset); CESC cis rs2439831 0.681 rs540388 chr15:43606494 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.73 0.55 1.49e-22 Lung cancer in ever smokers; CESC cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg07507251 chr3:52567010 NT5DC2 0.32 5.64 0.33 4.4e-8 Intelligence (multi-trait analysis); CESC cis rs1215050 0.740 rs783945 chr4:99014394 G/A cg05340658 chr4:99064831 C4orf37 -0.57 -7.68 -0.43 3.05e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1008375 0.863 rs10003291 chr4:17600728 A/C cg16339924 chr4:17578868 LAP3 0.76 9.5 0.5 1.31e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg23978390 chr7:1156363 C7orf50 0.51 6.68 0.38 1.41e-10 Longevity;Endometriosis; CESC cis rs4927850 0.723 rs7630825 chr3:195753740 T/C cg12923728 chr3:195709715 SDHAP1 -0.68 -9.28 -0.5 6.46e-18 Pancreatic cancer; CESC cis rs2204008 0.754 rs11181643 chr12:38380553 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.02 0.35 5.68e-9 Bladder cancer; CESC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg25036284 chr2:26402008 FAM59B -0.57 -6.58 -0.37 2.57e-10 Gut microbiome composition (summer); CESC cis rs11711311 1.000 rs9879760 chr3:113457948 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.27 0.53 4.81e-21 IgG glycosylation; CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg03762994 chr17:6899332 ALOX12 0.4 7.03 0.4 1.77e-11 Tonsillectomy; CESC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg03526776 chr6:41159608 TREML2 0.39 6.5 0.37 4.03e-10 Alzheimer's disease (late onset); CESC cis rs11583043 1.000 rs11583043 chr1:101466054 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.53 5.89 0.34 1.17e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs9611565 0.559 rs6002408 chr22:41967870 C/T cg06481639 chr22:41940642 POLR3H -0.57 -6.18 -0.35 2.4e-9 Vitiligo; CESC cis rs897984 0.542 rs7294 chr16:31102321 A/G cg02466173 chr16:30829666 NA 0.42 7.24 0.41 4.91e-12 Dementia with Lewy bodies; CESC cis rs8114671 0.562 rs6058120 chr20:33402829 A/G cg08999081 chr20:33150536 PIGU 0.4 5.64 0.33 4.3e-8 Height; CESC cis rs7927592 0.672 rs10501398 chr11:68331715 C/G cg16797656 chr11:68205561 LRP5 -0.5 -7.85 -0.43 1.03e-13 Total body bone mineral density; CESC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg21951975 chr1:209979733 IRF6 -0.49 -8.15 -0.45 1.46e-14 Orofacial clefts; CESC cis rs6540556 0.859 rs12079960 chr1:209937168 A/C cg05527609 chr1:210001259 C1orf107 -0.48 -6.05 -0.35 4.95e-9 Red blood cell count; CESC trans rs9850225 0.719 rs4856616 chr3:80466481 A/C cg18067127 chr19:3767310 MRPL54 0.38 6.09 0.35 4.04e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg24846343 chr22:24311635 DDTL 0.68 11.41 0.57 8.24e-25 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00219956 chr16:30794205 ZNF629 -0.45 -6.18 -0.35 2.43e-9 Gut microbiota (bacterial taxa); CESC cis rs3091242 0.933 rs11249251 chr1:25770188 C/G cg12412775 chr1:25698385 RHCE -0.28 -5.13 -0.3 5.65e-7 Erythrocyte sedimentation rate; CESC cis rs896854 0.517 rs2013597 chr8:95951807 G/A cg13393036 chr8:95962371 TP53INP1 -0.46 -8.3 -0.45 5.34e-15 Type 2 diabetes; CESC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.76 10.81 0.55 8.12e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.16 0.45 1.32e-14 Menopause (age at onset); CESC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg14949292 chr17:78079608 GAA -0.33 -5.08 -0.3 6.97e-7 Yeast infection; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17808901 chr3:39093368 WDR48 0.5 6.47 0.37 4.59e-10 Gut microbiota (bacterial taxa); CESC cis rs35110281 0.607 rs4819212 chr21:44977455 G/A cg04455712 chr21:45112962 RRP1B 0.35 5.09 0.3 6.86e-7 Mean corpuscular volume; CESC cis rs67397200 0.590 rs12327712 chr19:17424947 T/G cg22549504 chr19:17448937 GTPBP3 0.49 6.14 0.35 2.92e-9 Breast cancer;Breast Cancer in BRCA1 mutation carriers;Breast cancer (estrogen-receptor negative); CESC cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg24879335 chr3:133465180 TF 0.47 9.11 0.49 2.14e-17 Iron status biomarkers (transferrin levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17208363 chr15:41851964 TYRO3 -0.56 -6.2 -0.36 2.21e-9 Gut microbiome composition (summer); CESC cis rs854765 0.575 rs7207821 chr17:17891781 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.63 9.08 0.49 2.57e-17 Total body bone mineral density; CESC cis rs12136530 0.593 rs12136926 chr1:19710794 G/A cg01832549 chr1:19774989 CAPZB -0.36 -5.33 -0.31 2.08e-7 Lead levels in blood; CESC cis rs7584330 0.695 rs77922291 chr2:238366317 T/G cg14458575 chr2:238380390 NA 0.62 8.43 0.46 2.19e-15 Prostate cancer; CESC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg05255149 chr17:80675120 FN3KRP -0.46 -5.32 -0.31 2.17e-7 Breast cancer; CESC cis rs67366981 1.000 rs17105547 chr14:77698358 G/A cg22824376 chr14:77648248 TMEM63C 0.68 5.72 0.33 2.9e-8 Obsessive-compulsive symptoms; CESC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg20203395 chr5:56204925 C5orf35 -0.4 -5.21 -0.3 3.79e-7 Initial pursuit acceleration; CESC cis rs2274273 0.967 rs11622740 chr14:55617844 G/A cg04306507 chr14:55594613 LGALS3 0.28 5.23 0.31 3.42e-7 Protein biomarker; CESC cis rs2625529 0.730 rs4511483 chr15:72138590 G/A cg16672083 chr15:72433130 SENP8 -0.4 -5.93 -0.34 9.45e-9 Red blood cell count; CESC cis rs854765 0.547 rs2955353 chr17:17948979 T/C cg04398451 chr17:18023971 MYO15A 0.73 10.55 0.54 5.95e-22 Total body bone mineral density; CESC cis rs3126085 0.877 rs4415568 chr1:152181207 G/A cg03465714 chr1:152285911 FLG -0.43 -5.16 -0.3 4.81e-7 Atopic dermatitis; CESC cis rs2637266 1.000 rs7897348 chr10:78359620 G/A cg18941641 chr10:78392320 NA 0.42 7.87 0.44 9.04e-14 Pulmonary function; CESC cis rs6540556 0.769 rs12030655 chr1:209922123 G/T cg05527609 chr1:210001259 C1orf107 -0.48 -5.8 -0.34 1.85e-8 Red blood cell count; CESC cis rs1003719 0.586 rs2298685 chr21:38533390 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.06 -0.44 2.72e-14 Eye color traits; CESC cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg04455712 chr21:45112962 RRP1B 0.39 5.72 0.33 2.86e-8 Mean corpuscular volume; CESC cis rs17407555 1.000 rs17407555 chr4:10274994 A/G cg11266682 chr4:10021025 SLC2A9 -0.48 -5.94 -0.34 8.93e-9 Schizophrenia (age at onset); CESC cis rs929354 0.742 rs7806775 chr7:156947199 A/G cg05182265 chr7:156933206 UBE3C -0.5 -7.18 -0.4 7.24e-12 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17297071 chr21:26934424 MIR155HG 0.45 6.34 0.36 1e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06564473 chr11:601660 PHRF1 -0.57 -7.24 -0.41 4.77e-12 Gut microbiome composition (summer); CESC cis rs2625529 0.730 rs2957737 chr15:72265410 A/G cg16672083 chr15:72433130 SENP8 0.41 5.96 0.34 8.23e-9 Red blood cell count; CESC cis rs9308433 0.529 rs867445 chr1:214502230 C/G cg06198575 chr1:214491504 SMYD2 0.48 5.78 0.33 2.1e-8 IgG glycosylation; CESC cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.39 0.31 1.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7508 0.668 rs10087428 chr8:17918454 G/T cg18067069 chr8:17937731 ASAH1 -0.4 -5.21 -0.3 3.88e-7 Atrial fibrillation; CESC cis rs847577 0.748 rs55784506 chr7:97718201 G/A cg24562669 chr7:97807699 LMTK2 0.63 10.23 0.53 6.29e-21 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08889949 chr3:49044473 P4HTM;WDR6 -0.46 -6.12 -0.35 3.37e-9 Gut microbiota (bacterial taxa); CESC cis rs4466137 0.909 rs4466136 chr5:82985576 T/G cg16102102 chr5:83017553 HAPLN1 -0.41 -6.18 -0.35 2.44e-9 Prostate cancer; CESC cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.68 7.98 0.44 4.34e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs748404 0.587 rs9920879 chr15:43639770 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.54 8.4 0.46 2.66e-15 Lung cancer; CESC cis rs735396 1.000 rs1169313 chr12:121442670 C/T cg02403541 chr12:121454288 C12orf43 -0.62 -8.97 -0.48 5.62e-17 N-glycan levels; CESC cis rs9611565 0.546 rs2092274 chr22:42123737 A/G cg06634786 chr22:41940651 POLR3H 0.66 6.7 0.38 1.24e-10 Vitiligo; CESC cis rs4132509 0.696 rs12023642 chr1:243767826 T/G cg21452805 chr1:244014465 NA 0.64 6.83 0.39 5.74e-11 RR interval (heart rate); CESC cis rs7586879 0.616 rs10203386 chr2:25136866 T/A cg01884057 chr2:25150051 NA 0.37 6.82 0.39 6.11e-11 Body mass index; CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg01516881 chr6:292596 DUSP22 -0.84 -11.26 -0.57 2.69e-24 Menopause (age at onset); CESC trans rs17508449 0.819 rs79220465 chr1:114171341 A/T cg23028848 chr11:57092561 TNKS1BP1 -0.75 -6.1 -0.35 3.7e-9 Leprosy; CESC trans rs11098499 0.754 rs878376 chr4:120237702 G/A cg25214090 chr10:38739885 LOC399744 0.64 8.86 0.48 1.19e-16 Corneal astigmatism; CESC cis rs2404602 0.692 rs1471780 chr15:77026526 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs7122539 0.603 rs508443 chr11:66509369 C/T cg24851651 chr11:66362959 CCS -0.49 -6.96 -0.39 2.63e-11 HIV-1 susceptibility; CESC cis rs1729951 0.575 rs16844325 chr3:136678161 C/G cg03617693 chr3:136751559 NA 0.37 5.21 0.3 3.77e-7 Neuroticism; CESC cis rs1707322 0.893 rs9919275 chr1:46441360 A/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8111998 0.826 rs4932774 chr19:22766593 G/T cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs910316 0.737 rs175048 chr14:75479894 A/T cg11812906 chr14:75593930 NEK9 -0.8 -13.2 -0.63 6.54e-31 Height; CESC trans rs7937682 0.889 rs10749984 chr11:111492861 T/C cg18187862 chr3:45730750 SACM1L 0.48 6.01 0.35 6.26e-9 Primary sclerosing cholangitis; CESC cis rs9399135 0.967 rs6915770 chr6:135369214 G/A cg24558204 chr6:135376177 HBS1L 0.51 6.99 0.39 2.27e-11 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21853250 chr8:681212 ERICH1 0.58 6.32 0.36 1.08e-9 Gut microbiome composition (summer); CESC cis rs9287719 0.967 rs2884233 chr2:10745303 G/A cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg07153921 chr17:41440717 NA -0.38 -5.19 -0.3 4.23e-7 Menopause (age at onset); CESC cis rs1878047 0.702 rs12972903 chr19:51775738 C/T cg14884932 chr19:51774451 NA -0.37 -5.16 -0.3 4.87e-7 Body mass index; CESC cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg22875332 chr1:76189707 ACADM -0.62 -6.27 -0.36 1.47e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3736485 0.934 rs28393906 chr15:51867605 T/A cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12500824 0.564 rs34078673 chr4:77232408 A/G cg20311846 chr4:77356250 SHROOM3 0.4 7.77 0.43 1.71e-13 Coronary artery disease; CESC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg19592336 chr6:28129416 ZNF389 0.59 7.78 0.43 1.63e-13 Depression; CESC cis rs57244997 0.725 rs73785320 chr6:162439590 A/C cg17173639 chr6:162384350 PARK2 -0.46 -5.27 -0.31 2.78e-7 Mosquito bite size; CESC trans rs208520 1.000 rs12189683 chr6:66977716 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.83 -9.32 -0.5 4.61e-18 Exhaled nitric oxide output; CESC cis rs4423214 1.000 rs4944956 chr11:71167765 C/T cg24826892 chr11:71159390 DHCR7 0.44 5.08 0.3 7.05e-7 Vitamin D levels; CESC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg24562669 chr7:97807699 LMTK2 0.48 6.8 0.39 6.74e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs7914558 0.966 rs10786727 chr10:104698523 G/A cg15744005 chr10:104629667 AS3MT -0.35 -5.48 -0.32 9.76e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg05234568 chr11:5960015 NA -0.64 -9.02 -0.48 3.81e-17 DNA methylation (variation); CESC cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.15 0.3 5.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2732480 0.577 rs2634691 chr12:48708259 G/T cg04545296 chr12:48745243 ZNF641 0.43 7.3 0.41 3.34e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9549260 0.712 rs9532564 chr13:41160579 C/G cg21288729 chr13:41239152 FOXO1 0.55 5.04 0.3 8.81e-7 Red blood cell count; CESC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg03452623 chr4:187889614 NA -0.88 -16.15 -0.7 2.59e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs13191362 0.507 rs2023036 chr6:163122736 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.53 6.38 0.37 7.67e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06697439 chr19:59031463 ZBTB45 -0.43 -6.01 -0.35 6.27e-9 Gut microbiota (bacterial taxa); CESC cis rs2997447 0.761 rs61776596 chr1:26454968 T/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.16 0.3 4.76e-7 QRS complex (12-leadsum); CESC cis rs1153858 0.621 rs1719237 chr15:45579822 G/A cg21132104 chr15:45694354 SPATA5L1 0.75 9.05 0.49 3.22e-17 Homoarginine levels; CESC cis rs66887589 0.934 rs41464847 chr4:120532401 A/G cg09307838 chr4:120376055 NA -0.46 -6.17 -0.35 2.55e-9 Diastolic blood pressure; CESC cis rs11734570 0.581 rs79354477 chr4:38597448 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.6 7.34 0.41 2.7e-12 Inflammatory bowel disease;Crohn's disease; CESC cis rs881375 0.934 rs1468671 chr9:123657502 C/G cg14580859 chr9:123691850 NA 0.29 5.15 0.3 5.17e-7 Rheumatoid arthritis; CESC cis rs9916302 0.706 rs2879259 chr17:37410892 C/G cg07936489 chr17:37558343 FBXL20 -0.94 -10.92 -0.56 3.58e-23 Glomerular filtration rate (creatinine); CESC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg13880726 chr7:1868755 MAD1L1 0.44 6.03 0.35 5.39e-9 Bipolar disorder and schizophrenia; CESC cis rs1874326 0.504 rs7793703 chr7:138113421 T/G cg18008034 chr7:138118925 NA -0.41 -5.22 -0.31 3.63e-7 Quantitative traits; CESC cis rs9329221 0.512 rs7843924 chr8:9976540 C/T cg21625330 chr8:9911636 MSRA -0.41 -5.26 -0.31 3.04e-7 Neuroticism; CESC cis rs7267979 0.966 rs2482923 chr20:25308981 T/C cg08601574 chr20:25228251 PYGB -0.36 -5.06 -0.3 7.89e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs6163 0.727 rs284854 chr10:104574562 T/G cg04362960 chr10:104952993 NT5C2 -0.49 -6.78 -0.38 7.89e-11 Waist circumference;Hip circumference; CESC cis rs870825 0.616 rs4610378 chr4:185624220 C/T cg04058563 chr4:185651563 MLF1IP -0.63 -7.46 -0.42 1.24e-12 Blood protein levels; CESC cis rs4950322 0.857 rs7522219 chr1:146838619 T/C cg22381352 chr1:146742008 CHD1L -0.45 -5.19 -0.3 4.12e-7 Protein quantitative trait loci; CESC trans rs3780486 0.713 rs3780489 chr9:33129844 G/T cg20290983 chr6:43655470 MRPS18A 0.99 18.34 0.75 4.45e-49 IgG glycosylation; CESC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg21963583 chr11:68658836 MRPL21 0.37 5.41 0.32 1.39e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9640161 0.742 rs2159235 chr7:150017228 T/C cg10018233 chr7:150070692 REPIN1 0.45 7.22 0.41 5.48e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg09658497 chr7:2847517 GNA12 -0.43 -5.87 -0.34 1.27e-8 Height; CESC cis rs12545109 0.807 rs13263281 chr8:57346582 C/A cg09654669 chr8:57350985 NA -0.51 -6.48 -0.37 4.41e-10 Obesity-related traits; CESC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg08470875 chr2:26401718 FAM59B 0.75 7.79 0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs10504073 0.669 rs818560 chr8:50035417 C/T cg00325661 chr8:49890786 NA 0.51 7.5 0.42 9.61e-13 Blood metabolite ratios; CESC cis rs7267979 0.833 rs4619688 chr20:25244101 C/G cg08601574 chr20:25228251 PYGB 0.42 5.92 0.34 1.01e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2204008 0.754 rs11181244 chr12:38302454 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Bladder cancer; CESC cis rs7940866 0.774 rs2162059 chr11:130831224 C/T cg12179176 chr11:130786555 SNX19 0.67 10.28 0.53 4.38e-21 Schizophrenia; CESC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs9303401 0.659 rs7225896 chr17:56637337 T/C cg10487724 chr17:56770010 TEX14;RAD51C 1.01 11.43 0.57 7.19e-25 Cognitive test performance; CESC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg11890956 chr21:40555474 PSMG1 -0.66 -9.23 -0.49 9.1e-18 Menarche (age at onset); CESC cis rs2050392 0.624 rs303436 chr10:30731893 G/T cg25182066 chr10:30743637 MAP3K8 -0.44 -5.78 -0.33 2.07e-8 Inflammatory bowel disease; CESC cis rs1020064 0.636 rs2576750 chr2:105916635 A/T cg02079111 chr2:105885981 TGFBRAP1 0.39 5.2 0.3 3.96e-7 AIDS; CESC cis rs6964587 0.626 rs10243083 chr7:91552530 G/A cg17063962 chr7:91808500 NA -0.45 -6.29 -0.36 1.29e-9 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10891888 chr12:46765615 SLC38A2 0.48 6.78 0.38 7.87e-11 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14378659 chr8:8860465 ERI1 0.69 7.83 0.43 1.2e-13 Gut microbiome composition (summer); CESC cis rs8049040 0.609 rs9940485 chr16:71486105 C/T cg08717414 chr16:71523259 ZNF19 -0.58 -6.66 -0.38 1.57e-10 Blood protein levels; CESC cis rs9325144 0.647 rs34963631 chr12:38912260 T/A cg26384229 chr12:38710491 ALG10B -0.56 -7.75 -0.43 2.02e-13 Morning vs. evening chronotype; CESC cis rs11969893 0.850 rs9791284 chr6:101353886 G/A cg12253828 chr6:101329408 ASCC3 0.91 6.53 0.37 3.33e-10 Economic and political preferences (immigration/crime); CESC cis rs7829975 0.742 rs882462 chr8:8678530 G/A cg06636001 chr8:8085503 FLJ10661 0.45 5.83 0.34 1.58e-8 Mood instability; CESC cis rs9649465 0.967 rs6950373 chr7:123361773 C/T cg04330084 chr7:123175371 IQUB -0.39 -5.23 -0.31 3.47e-7 Migraine; CESC cis rs7666738 0.800 rs2865988 chr4:99067807 T/C cg05340658 chr4:99064831 C4orf37 0.83 12.82 0.62 1.36e-29 Colonoscopy-negative controls vs population controls; CESC cis rs4664308 0.710 rs13001911 chr2:161020703 G/C cg03641300 chr2:160917029 PLA2R1 -0.54 -7.75 -0.43 2.01e-13 Idiopathic membranous nephropathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24047259 chr14:65347275 NA 0.53 6.28 0.36 1.35e-9 Gut microbiome composition (summer); CESC cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.56 -6.35 -0.36 9.23e-10 Multiple sclerosis; CESC trans rs17764205 0.568 rs72987040 chr19:3251116 C/A cg02013146 chr16:89452259 ANKRD11 -0.77 -6.05 -0.35 5.04e-9 Bipolar disorder and schizophrenia; CESC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg00149659 chr3:10157352 C3orf10 0.69 8.03 0.44 3.14e-14 Alzheimer's disease; CESC cis rs4629180 0.675 rs13388183 chr2:102111912 A/G cg04415270 chr2:102091202 RFX8 -0.31 -5.45 -0.32 1.18e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg04414720 chr1:150670196 GOLPH3L -0.5 -6.55 -0.37 2.93e-10 Urate levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07151560 chr1:111991897 WDR77;ATP5F1 0.53 6.0 0.35 6.36e-9 Gut microbiome composition (summer); CESC cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg24549020 chr5:56110836 MAP3K1 -0.52 -6.46 -0.37 4.87e-10 Initial pursuit acceleration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05922971 chr5:43121458 ZNF131 -0.42 -6.06 -0.35 4.54e-9 Fibrinogen levels; CESC cis rs8180040 0.967 rs17411375 chr3:47395135 C/T cg27129171 chr3:47204927 SETD2 -0.68 -10.45 -0.54 1.24e-21 Colorectal cancer; CESC cis rs12579753 0.719 rs10862377 chr12:82270172 C/T cg23701643 chr12:82153290 PPFIA2 -0.36 -5.29 -0.31 2.57e-7 Resting heart rate; CESC trans rs10028773 0.568 rs6838457 chr4:120267367 A/G cg25214090 chr10:38739885 LOC399744 0.59 8.14 0.45 1.55e-14 Educational attainment; CESC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg25019033 chr10:957182 NA -0.55 -6.18 -0.36 2.38e-9 Eosinophil percentage of granulocytes; CESC cis rs9790314 1.000 rs336589 chr3:161080358 C/T cg03342759 chr3:160939853 NMD3 -0.45 -5.97 -0.34 7.5e-9 Morning vs. evening chronotype; CESC cis rs12541635 0.677 rs7460291 chr8:107057861 A/G cg10147462 chr8:107024639 NA 0.43 6.41 0.37 6.55e-10 Age of smoking initiation; CESC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC cis rs4481887 0.927 rs4472779 chr1:248474603 G/A cg00666640 chr1:248458726 OR2T12 0.34 5.89 0.34 1.18e-8 Common traits (Other); CESC cis rs10751667 0.666 rs10902247 chr11:953686 G/A cg06064525 chr11:970664 AP2A2 -0.48 -9.52 -0.5 1.15e-18 Alzheimer's disease (late onset); CESC cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg10523679 chr1:76189770 ACADM 0.63 6.03 0.35 5.41e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9487051 0.700 rs9400266 chr6:109596193 T/A cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs977987 0.806 rs2865530 chr16:75414376 G/T cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.78e-8 Dupuytren's disease; CESC cis rs3087591 1.000 rs2525578 chr17:29711411 A/G cg24425628 chr17:29625626 OMG;NF1 -0.49 -6.09 -0.35 4.05e-9 Hip circumference; CESC cis rs367615 0.506 rs2914680 chr5:108787146 A/G cg17395555 chr5:108820864 NA -0.6 -10.07 -0.53 2.11e-20 Colorectal cancer (SNP x SNP interaction); CESC cis rs17376456 0.825 rs36042718 chr5:93180997 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.37 0.31 1.74e-7 Diabetic retinopathy; CESC cis rs6690583 0.623 rs898036 chr1:85521904 A/T cg22488158 chr1:85528044 WDR63 0.58 5.57 0.32 6.27e-8 Serum sulfate level; CESC cis rs7520050 0.966 rs12144263 chr1:46352446 G/A cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.42e-7 Red blood cell count;Reticulocyte count; CESC trans rs6479874 0.831 rs2456758 chr10:52738018 A/G cg02905881 chr2:48009730 MSH6 0.79 6.19 0.36 2.26e-9 Migraine; CESC cis rs4604732 0.631 rs1106720 chr1:247624681 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs5753618 0.504 rs9609296 chr22:31891784 T/G cg02404636 chr22:31891804 SFI1 0.42 5.44 0.32 1.23e-7 Colorectal cancer; CESC cis rs1878931 0.543 rs1129568 chr16:3483475 G/A cg22508957 chr16:3507546 NAT15 -0.42 -6.13 -0.35 3.23e-9 Body mass index (adult); CESC cis rs8180040 1.000 rs295442 chr3:47335881 A/C cg27129171 chr3:47204927 SETD2 0.64 9.57 0.51 7.8e-19 Colorectal cancer; CESC cis rs17021463 0.673 rs57939388 chr4:95282365 A/G cg11021082 chr4:95130006 SMARCAD1 0.5 6.91 0.39 3.66e-11 Testicular germ cell tumor; CESC cis rs616402 0.527 rs589151 chr1:10567711 C/T cg17425144 chr1:10567563 PEX14 0.38 6.09 0.35 4.02e-9 Breast size; CESC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg27170947 chr2:26402098 FAM59B 0.64 7.8 0.43 1.39e-13 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.48e-10 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17008164 chr15:31507824 NA 0.6 7.02 0.4 1.87e-11 Gut microbiome composition (summer); CESC trans rs853679 0.599 rs149949 chr6:28011516 T/C cg06606381 chr12:133084897 FBRSL1 -0.74 -6.49 -0.37 4.27e-10 Depression; CESC cis rs1129187 0.837 rs4714634 chr6:42901120 G/A cg14338887 chr6:42928500 GNMT 0.37 5.26 0.31 2.93e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg20503657 chr10:835505 NA 0.76 7.88 0.44 8.52e-14 Eosinophil percentage of granulocytes; CESC cis rs6500395 0.962 rs1039341 chr16:48574869 C/T cg04672837 chr16:48644449 N4BP1 0.45 5.4 0.31 1.51e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2354432 0.556 rs2883319 chr1:146838177 A/G cg25205988 chr1:146714368 CHD1L -1.02 -8.38 -0.46 3.08e-15 Mitochondrial DNA levels; CESC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg01988459 chr11:68622903 NA 0.4 5.68 0.33 3.54e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs116095464 0.558 rs6872854 chr5:209038 G/T cg22857025 chr5:266934 NA -1.25 -18.53 -0.75 9.96e-50 Breast cancer; CESC cis rs863345 0.901 rs2213947 chr1:158445699 A/G cg12129480 chr1:158549410 OR10X1 -0.31 -6.07 -0.35 4.42e-9 Pneumococcal bacteremia; CESC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.3 0.36 1.23e-9 Bipolar disorder; CESC cis rs10484885 0.715 rs2585013 chr6:90553402 T/G cg13799429 chr6:90582589 CASP8AP2 -0.86 -10.96 -0.56 2.66e-23 QRS interval (sulfonylurea treatment interaction); CESC cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg10556349 chr10:835070 NA 0.76 6.35 0.36 9.42e-10 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19230709 chr19:4933046 UHRF1 -0.63 -6.92 -0.39 3.35e-11 Gut microbiome composition (summer); CESC cis rs9318086 0.712 rs66683041 chr13:24442090 T/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.6 6.82 0.39 6.2e-11 Myopia (pathological); CESC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.66 9.32 0.5 4.58e-18 Menarche (age at onset); CESC cis rs7267979 0.586 rs6050432 chr20:25184028 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.66 10.78 0.55 1.07e-22 Liver enzyme levels (alkaline phosphatase); CESC cis rs561341 0.689 rs578635 chr17:30289897 A/C cg23018236 chr17:30244563 NA -0.38 -5.1 -0.3 6.62e-7 Hip circumference adjusted for BMI; CESC cis rs9911578 0.967 rs302843 chr17:56727986 C/T cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC cis rs9291683 0.679 rs3756225 chr4:10094133 G/C cg00071950 chr4:10020882 SLC2A9 -0.59 -9.59 -0.51 7.06e-19 Bone mineral density; CESC cis rs6032067 0.925 rs62208424 chr20:43813341 G/A cg10761708 chr20:43804764 PI3 0.53 6.38 0.36 7.98e-10 Blood protein levels; CESC cis rs4803468 1.000 rs2569754 chr19:41936734 A/G cg14132834 chr19:41945861 ATP5SL -0.69 -8.69 -0.47 3.72e-16 Height; CESC cis rs9399137 0.507 rs11759062 chr6:135381248 A/C cg24558204 chr6:135376177 HBS1L 0.69 9.52 0.5 1.12e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs4909189 1.000 rs71547530 chr7:158135503 A/G cg25566285 chr7:158114605 PTPRN2 0.43 5.42 0.32 1.36e-7 Response to amphetamines; CESC trans rs208520 0.690 rs1563929 chr6:66702108 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.97 12.46 0.61 2.35e-28 Exhaled nitric oxide output; CESC cis rs7520050 0.966 rs34102169 chr1:46424864 G/T cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.74e-9 Red blood cell count;Reticulocyte count; CESC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg00074818 chr8:8560427 CLDN23 0.36 5.22 0.31 3.64e-7 Obesity-related traits; CESC trans rs1814175 0.669 rs12364577 chr11:49707361 A/C cg15704280 chr7:45808275 SEPT13 -0.84 -11.66 -0.58 1.23e-25 Height; CESC cis rs60843830 1.000 rs56321614 chr2:268191 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.88 12.15 0.6 2.6e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg03467027 chr4:99064603 C4orf37 0.42 5.11 0.3 6.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.840 rs9607799 chr22:41777558 A/G cg06634786 chr22:41940651 POLR3H -0.68 -7.28 -0.41 3.87e-12 Vitiligo; CESC cis rs30380 0.632 rs26489 chr5:96133427 C/T cg16492584 chr5:96139282 ERAP1 -0.49 -6.84 -0.39 5.49e-11 Cerebrospinal fluid biomarker levels; CESC cis rs7666738 0.830 rs2903152 chr4:99067992 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.5 0.46 1.41e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2281845 0.507 rs12025414 chr1:201100496 A/G cg06714761 chr1:201096289 NA 0.44 6.83 0.39 5.8200000000000003e-11 Permanent tooth development; CESC trans rs7246760 0.867 rs2287843 chr19:9769913 G/A cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs977987 0.806 rs4993969 chr16:75411521 A/T cg03315344 chr16:75512273 CHST6 0.38 5.5 0.32 8.89e-8 Dupuytren's disease; CESC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg06808227 chr14:105710500 BRF1 -0.51 -5.78 -0.33 2.08e-8 Mean platelet volume;Platelet distribution width; CESC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg24399712 chr22:39784796 NA -0.83 -11.47 -0.58 5.45e-25 Intelligence (multi-trait analysis); CESC cis rs7919006 1.000 rs6480766 chr10:76803880 G/A cg01390419 chr10:76803856 DUPD1 0.39 5.56 0.32 6.59e-8 Weight; CESC cis rs7618501 0.933 rs3811695 chr3:49761613 C/T cg24308560 chr3:49941425 MST1R 0.51 7.05 0.4 1.58e-11 Intelligence (multi-trait analysis); CESC cis rs250677 0.687 rs384979 chr5:148459267 C/T cg12140854 chr5:148520817 ABLIM3 0.41 5.13 0.3 5.52e-7 Breast cancer; CESC cis rs7633770 0.805 rs11130098 chr3:46661926 A/G cg11219411 chr3:46661640 NA -0.47 -7.42 -0.41 1.63e-12 Coronary artery disease; CESC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg14926445 chr8:58193284 C8orf71 -0.54 -5.16 -0.3 4.76e-7 Developmental language disorder (linguistic errors); CESC cis rs7914558 0.966 rs12571568 chr10:104891396 C/G cg04362960 chr10:104952993 NT5C2 0.46 5.92 0.34 9.98e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2243480 0.522 rs12698511 chr7:65474919 G/T cg25894440 chr7:65020034 NA -0.78 -5.63 -0.33 4.69e-8 Diabetic kidney disease; CESC cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6963495 0.818 rs55922564 chr7:105155890 G/A cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg21984481 chr17:79567631 NPLOC4 -0.49 -8.04 -0.44 2.97e-14 Eye color traits; CESC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.16 0.3 4.78e-7 Bipolar disorder; CESC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.43 0.32 1.24e-7 Bipolar disorder; CESC cis rs10949662 1.000 rs10949662 chr7:157534105 A/G cg11757124 chr7:157526947 PTPRN2 0.43 5.09 0.3 6.69e-7 Intelligence (multi-trait analysis); CESC cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.03 0.3 8.86e-7 Personality dimensions; CESC cis rs6460942 0.915 rs62448620 chr7:12458170 C/T cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC trans rs5756813 0.754 rs34848977 chr22:38165587 G/A cg19894588 chr14:64061835 NA -0.71 -8.82 -0.48 1.52e-16 Optic cup area;Vertical cup-disc ratio; CESC cis rs1577917 0.727 rs9444361 chr6:86400900 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 7.41 0.41 1.69e-12 Response to antipsychotic treatment; CESC cis rs2066819 1.000 rs2371454 chr12:56647243 A/G cg26734620 chr12:56694298 CS -1.07 -6.58 -0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg00310523 chr12:86230176 RASSF9 0.36 5.55 0.32 6.85e-8 Major depressive disorder; CESC cis rs4819052 0.679 rs2838860 chr21:46684904 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 9.47 0.5 1.67e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6570726 1.000 rs6570699 chr6:145920732 G/A cg23711669 chr6:146136114 FBXO30 0.67 9.61 0.51 5.87e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs3857067 1.000 rs1509940 chr4:95018758 C/T cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.05e-14 QT interval; CESC cis rs950027 0.549 rs1719250 chr15:45609773 A/G cg21132104 chr15:45694354 SPATA5L1 0.61 7.38 0.41 2.06e-12 Response to fenofibrate (adiponectin levels); CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg23708337 chr7:1209742 NA 0.5 5.57 0.32 6.3e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17280624 chr4:129208725 PGRMC2 -0.61 -7.05 -0.4 1.59e-11 Gut microbiome composition (summer); CESC cis rs2832191 0.679 rs2705659 chr21:30363908 G/C cg08807101 chr21:30365312 RNF160 0.96 14.93 0.68 5.23e-37 Dental caries; CESC cis rs367943 1.000 rs348925 chr5:112817533 T/A cg12552261 chr5:112820674 MCC -0.62 -7.78 -0.43 1.58e-13 Type 2 diabetes; CESC cis rs7809950 1.000 rs2057837 chr7:107222725 C/G cg23024343 chr7:107201750 COG5 0.4 5.54 0.32 7.44e-8 Coronary artery disease; CESC cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg10556349 chr10:835070 NA 0.56 5.32 0.31 2.16e-7 Eosinophil percentage of granulocytes; CESC cis rs2797160 1.000 rs1418948 chr6:126007018 C/T cg05901451 chr6:126070800 HEY2 0.45 6.54 0.37 3.11e-10 Endometrial cancer; CESC cis rs10905065 0.833 rs6602259 chr10:5844628 C/T cg11519256 chr10:5708881 ASB13 0.43 5.99 0.35 6.82e-9 Menopause (age at onset); CESC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 10.75 0.55 1.29e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4654899 0.680 rs12407731 chr1:21254789 C/T cg05370193 chr1:21551575 ECE1 0.34 5.22 0.31 3.64e-7 Superior frontal gyrus grey matter volume; CESC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.54 0.42 7.65e-13 Prudent dietary pattern; CESC cis rs6088580 0.634 rs6141465 chr20:32967314 T/C cg06115741 chr20:33292138 TP53INP2 -0.47 -6.08 -0.35 4.22e-9 Glomerular filtration rate (creatinine); CESC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.718 rs10445306 chr17:37591422 A/G cg20243544 chr17:37824526 PNMT 0.52 6.53 0.37 3.3e-10 Glomerular filtration rate (creatinine); CESC cis rs240110 0.539 rs6934256 chr6:101338728 G/A cg09795085 chr6:101329169 ASCC3 0.46 6.0 0.35 6.5e-9 Neuroticism; CESC cis rs4803468 1.000 rs11883104 chr19:41923799 T/C cg08639244 chr19:41945921 ATP5SL -0.41 -5.03 -0.3 9.08e-7 Height; CESC cis rs854765 0.583 rs8075965 chr17:17853180 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.07 0.44 2.47e-14 Total body bone mineral density; CESC cis rs4718428 0.705 rs13231140 chr7:66361618 C/G cg18252515 chr7:66147081 NA -0.46 -5.17 -0.3 4.51e-7 Corneal structure; CESC cis rs3091242 0.933 rs1534954 chr1:25761924 A/T cg03538708 chr1:25844672 NA -0.42 -6.33 -0.36 1.07e-9 Erythrocyte sedimentation rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12141457 chr10:126182012 LHPP -0.55 -6.11 -0.35 3.55e-9 Gut microbiome composition (summer); CESC cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg04248312 chr19:17393744 ANKLE1 -0.86 -12.84 -0.62 1.15e-29 Systemic lupus erythematosus; CESC cis rs9487051 0.708 rs378447 chr6:109526823 G/A cg01475377 chr6:109611718 NA -0.44 -6.67 -0.38 1.45e-10 Reticulocyte fraction of red cells; CESC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg18876405 chr7:65276391 NA 0.5 5.98 0.34 7.33e-9 Aortic root size; CESC cis rs9457247 0.967 rs443570 chr6:167389925 G/A cg25258033 chr6:167368657 RNASET2 0.39 5.77 0.33 2.19e-8 Crohn's disease; CESC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg00290607 chr11:67383545 NA -0.44 -6.77 -0.38 8.09e-11 Mean corpuscular volume; CESC cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg03060546 chr3:49711283 APEH 0.44 5.38 0.31 1.61e-7 Parkinson's disease; CESC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg05564831 chr3:52568323 NT5DC2 0.44 6.84 0.39 5.53e-11 Bipolar disorder; CESC cis rs7937682 0.632 rs11608193 chr11:111732215 T/C cg22437258 chr11:111473054 SIK2 -0.49 -5.38 -0.31 1.64e-7 Primary sclerosing cholangitis; CESC cis rs11264213 0.901 rs72661636 chr1:36426483 T/C cg27506609 chr1:36549197 TEKT2 0.67 5.55 0.32 6.97e-8 Schizophrenia; CESC cis rs9788682 1.000 rs12438181 chr15:78812098 G/A cg06917634 chr15:78832804 PSMA4 -0.57 -6.59 -0.38 2.39e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs911555 0.755 rs1116095 chr14:103931879 A/G cg12935359 chr14:103987150 CKB 0.66 9.68 0.51 3.48e-19 Intelligence (multi-trait analysis); CESC cis rs9457247 0.624 rs17524252 chr6:167466978 T/G cg07741184 chr6:167504864 NA 0.37 6.49 0.37 4.2e-10 Crohn's disease; CESC cis rs4132509 0.895 rs6674314 chr1:243920895 A/G cg21452805 chr1:244014465 NA 0.42 5.26 0.31 2.9e-7 RR interval (heart rate); CESC cis rs6912958 0.712 rs7746465 chr6:88348996 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.72 -0.38 1.09e-10 Monocyte percentage of white cells; CESC cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg03467027 chr4:99064603 C4orf37 0.43 5.47 0.32 1.02e-7 Colonoscopy-negative controls vs population controls; CESC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg18350739 chr11:68623251 NA -0.48 -6.99 -0.39 2.22e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs1857353 0.520 rs17567748 chr1:75701159 A/G cg14377739 chr9:139699037 KIAA1984;LOC100131193 -0.78 -6.38 -0.36 7.95e-10 Whole-brain volume (Alzheimer's disease interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09606015 chr3:182511586 ATP11B -0.46 -6.58 -0.37 2.51e-10 Gut microbiota (bacterial taxa); CESC cis rs2243480 1.000 rs465359 chr7:65558164 C/T cg18252515 chr7:66147081 NA -1.39 -13.81 -0.65 4.83e-33 Diabetic kidney disease; CESC cis rs36051895 0.695 rs11794708 chr9:5023441 G/A cg02405213 chr9:5042618 JAK2 -0.5 -5.63 -0.33 4.66e-8 Pediatric autoimmune diseases; CESC trans rs79976124 0.879 rs17432710 chr6:66621744 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.75 8.58 0.47 7.94e-16 Type 2 diabetes; CESC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg19592336 chr6:28129416 ZNF389 0.53 6.84 0.39 5.4e-11 Parkinson's disease; CESC trans rs208520 0.690 rs12213575 chr6:66735989 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.22 0.6 1.51e-27 Exhaled nitric oxide output; CESC cis rs5753618 0.555 rs5749291 chr22:31907523 C/G cg02404636 chr22:31891804 SFI1 0.43 5.9 0.34 1.08e-8 Colorectal cancer; CESC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg17747265 chr1:1875780 NA -0.57 -9.25 -0.49 7.58e-18 Body mass index; CESC cis rs4588572 0.643 rs10440686 chr5:77688331 A/G cg11547950 chr5:77652471 NA 0.45 5.71 0.33 3.06e-8 Triglycerides; CESC cis rs854765 0.583 rs4553680 chr17:17857722 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.22 0.36 1.97e-9 Total body bone mineral density; CESC cis rs4604732 0.578 rs12038656 chr1:247623816 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.55 6.86 0.39 4.77e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.63 -9.12 -0.49 1.9e-17 Personality dimensions; CESC cis rs3020736 0.500 rs5996109 chr22:42493098 A/G cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC cis rs11098499 0.954 rs878373 chr4:120237484 A/T cg24375607 chr4:120327624 NA 0.46 5.6 0.33 5.42e-8 Corneal astigmatism; CESC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg26318627 chr11:63887540 MACROD1 0.33 5.08 0.3 7.24e-7 Platelet count; CESC cis rs7586879 0.616 rs6722587 chr2:25132192 C/A cg01884057 chr2:25150051 NA 0.36 7.02 0.4 1.82e-11 Body mass index; CESC trans rs10743315 0.557 rs77194694 chr12:19354075 A/G cg09562322 chr12:119419143 SRRM4 -0.47 -6.01 -0.35 6.01e-9 Gut microbiota (bacterial taxa); CESC trans rs208520 0.526 rs7776413 chr6:66783241 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -24.14 -0.83 7.13e-69 Exhaled nitric oxide output; CESC cis rs977987 0.645 rs34904236 chr16:75498253 G/T cg03315344 chr16:75512273 CHST6 0.52 7.64 0.42 3.9e-13 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02138756 chr12:685505 NINJ2 0.53 6.1 0.35 3.78e-9 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg13206674 chr6:150067644 NUP43 0.43 6.27 0.36 1.44e-9 Lung cancer; CESC cis rs11792861 0.926 rs72607163 chr9:111803128 G/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.48 6.03 0.35 5.57e-9 Menarche (age at onset); CESC cis rs9905704 0.718 rs62083527 chr17:56667853 T/C cg12560992 chr17:57184187 TRIM37 0.64 5.98 0.34 7.36e-9 Testicular germ cell tumor; CESC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg16405210 chr4:1374714 KIAA1530 -0.5 -6.69 -0.38 1.34e-10 Longevity; CESC cis rs2228479 0.702 rs62056100 chr16:89939753 C/T cg14709524 chr16:89940631 TCF25 0.88 6.36 0.36 8.79e-10 Skin colour saturation; CESC cis rs13082711 0.911 rs923941 chr3:27458914 A/G cg02860705 chr3:27208620 NA 0.58 7.29 0.41 3.49e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7116495 0.737 rs7101553 chr11:71753903 C/T cg07596299 chr11:71824057 C11orf51 -0.85 -5.35 -0.31 1.89e-7 Severe influenza A (H1N1) infection; CESC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg19729930 chr2:74357872 NA 0.93 12.29 0.6 8.99e-28 Gestational age at birth (maternal effect); CESC cis rs7772486 0.727 rs10223508 chr6:146285205 C/T cg23711669 chr6:146136114 FBXO30 -0.8 -10.95 -0.56 2.86e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.17 0.3 4.55e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.623 rs11651857 chr17:28926362 G/T cg19761014 chr17:28927070 LRRC37B2 0.85 6.59 0.38 2.33e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg19468946 chr17:37922297 IKZF3 -0.4 -5.45 -0.32 1.17e-7 Glomerular filtration rate (creatinine); CESC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -8.18 -0.45 1.19e-14 Developmental language disorder (linguistic errors); CESC cis rs3126085 0.935 rs4845426 chr1:152195359 A/G cg03465714 chr1:152285911 FLG -0.44 -5.43 -0.32 1.25e-7 Atopic dermatitis; CESC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg07424592 chr7:64974309 NA -0.4 -5.71 -0.33 2.95e-8 Calcium levels; CESC cis rs2933343 0.700 rs883602 chr3:128653952 A/G cg11901034 chr3:128598214 ACAD9 -0.36 -5.3 -0.31 2.38e-7 IgG glycosylation; CESC cis rs9796 0.866 rs66818965 chr15:41402279 G/A cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.23 -0.36 1.78e-9 Menopause (age at onset); CESC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg05313129 chr8:58192883 C8orf71 -0.54 -6.24 -0.36 1.76e-9 Developmental language disorder (linguistic errors); CESC cis rs3771570 1.000 rs62186400 chr2:242226700 A/G cg21155796 chr2:242212141 HDLBP 0.62 5.19 0.3 4.18e-7 Prostate cancer; CESC cis rs909674 0.734 rs5757675 chr22:39838892 G/T cg02038168 chr22:39784481 NA -0.66 -8.55 -0.47 9.78e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs2262909 0.853 rs56207853 chr19:22292357 C/T cg11619707 chr19:22235551 ZNF257 0.34 5.56 0.32 6.54e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs2997447 0.761 rs55960411 chr1:26437741 G/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs228769 0.543 rs170634 chr17:42175821 C/A cg13607699 chr17:42295918 UBTF -0.59 -7.76 -0.43 1.82e-13 Bone mineral density (hip);Bone mineral density (spine); CESC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg18032046 chr6:28092343 ZSCAN16 -0.54 -5.98 -0.34 7.07e-9 Parkinson's disease; CESC cis rs4974559 0.895 rs10004411 chr4:1354306 T/G cg02980000 chr4:1222292 CTBP1 0.63 6.21 0.36 2.06e-9 Systolic blood pressure; CESC cis rs4604732 0.536 rs10925056 chr1:247650472 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.61 8.04 0.44 3.06e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7937682 0.737 rs542275 chr11:111431614 C/T cg22437258 chr11:111473054 SIK2 0.64 8.2 0.45 1.04e-14 Primary sclerosing cholangitis; CESC cis rs9937943 0.720 rs112685216 chr16:74609517 G/A cg01733217 chr16:74700730 RFWD3 0.62 5.53 0.32 7.68e-8 Neutrophil percentage of white cells; CESC cis rs2522056 1.000 rs2706381 chr5:131810619 C/T cg24060327 chr5:131705240 SLC22A5 0.59 6.68 0.38 1.38e-10 Lymphocyte counts;Fibrinogen; CESC cis rs4423214 1.000 rs1981412 chr11:71138710 T/C cg05163923 chr11:71159392 DHCR7 0.78 10.47 0.54 1.04e-21 Vitamin D levels; CESC cis rs8067354 1.000 rs8067354 chr17:57821430 G/A cg02344993 chr17:57696989 CLTC 0.49 6.31 0.36 1.14e-9 Hemoglobin concentration; CESC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg14893161 chr1:205819251 PM20D1 0.87 14.89 0.68 7.26e-37 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23010568 chr17:568212 VPS53 -0.53 -6.42 -0.37 6.1e-10 Gut microbiome composition (summer); CESC cis rs9814567 0.929 rs9855013 chr3:134240414 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.08 -0.35 4.26e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg15485101 chr11:133734466 NA 0.41 6.54 0.37 3.09e-10 Childhood ear infection; CESC cis rs4629180 0.538 rs6746761 chr2:102122390 G/T cg21388029 chr2:102003306 CREG2 0.32 5.24 0.31 3.33e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs4969178 0.930 rs11077363 chr17:76397309 C/T cg20026190 chr17:76395443 PGS1 0.49 7.81 0.43 1.34e-13 HDL cholesterol levels; CESC cis rs4237845 0.611 rs10877036 chr12:58321650 A/G cg00677455 chr12:58241039 CTDSP2 -0.43 -5.58 -0.32 6.03e-8 Intelligence (multi-trait analysis); CESC cis rs17666538 0.535 rs896522 chr8:616991 A/G cg23958373 chr8:599963 NA 0.83 6.1 0.35 3.7e-9 IgG glycosylation; CESC trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -8.5 -0.46 1.4e-15 Intelligence (multi-trait analysis); CESC cis rs2011503 0.941 rs6511027 chr19:19391851 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.4 0.31 1.48e-7 Bipolar disorder; CESC cis rs8018808 0.967 rs10133896 chr14:77853806 C/T cg20045696 chr14:77926864 AHSA1 -0.38 -5.18 -0.3 4.46e-7 Myeloid white cell count; CESC cis rs9916302 0.706 rs6503504 chr17:37514412 A/G cg07936489 chr17:37558343 FBXL20 0.89 9.69 0.51 3.45e-19 Glomerular filtration rate (creatinine); CESC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg03806693 chr22:41940476 POLR3H -1.24 -16.78 -0.72 1.44e-43 Vitiligo; CESC cis rs3820928 0.934 rs16822890 chr2:227761477 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -5.72 -0.33 2.92e-8 Pulmonary function; CESC cis rs7666738 0.719 rs4699323 chr4:98967484 G/A cg03676636 chr4:99064102 C4orf37 0.41 5.49 0.32 9.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg10883421 chr6:151773342 RMND1;C6orf211 0.87 14.29 0.66 1e-34 Menarche (age at onset); CESC cis rs763121 0.925 rs4821815 chr22:39105707 G/A cg21395723 chr22:39101663 GTPBP1 0.45 6.08 0.35 4.28e-9 Menopause (age at onset); CESC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.83 -9.25 -0.49 7.55e-18 Gut microbiome composition (summer); CESC cis rs244293 0.730 rs12945579 chr17:53022714 A/T cg19360675 chr17:53046073 COX11;STXBP4 -0.44 -5.85 -0.34 1.48e-8 Menarche (age at onset); CESC cis rs17021463 0.645 rs12651347 chr4:95334650 G/A cg11021082 chr4:95130006 SMARCAD1 0.48 6.25 0.36 1.62e-9 Testicular germ cell tumor; CESC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs34779708 0.931 rs35136660 chr10:35385973 C/A cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6486730 1.000 rs6486730 chr12:129275027 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.39 -5.46 -0.32 1.08e-7 Systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03047724 chr7:139477895 TBXAS1;HIPK2 -0.45 -6.05 -0.35 4.95e-9 Fibrinogen levels; CESC cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg20607287 chr7:12443886 VWDE -0.79 -9.27 -0.49 6.78e-18 Coronary artery disease; CESC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg01988459 chr11:68622903 NA -0.38 -5.14 -0.3 5.45e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs478304 0.651 rs11227281 chr11:65496558 T/C cg10518572 chr11:65560635 OVOL1 -0.33 -6.61 -0.38 2.09e-10 Acne (severe); CESC cis rs3820068 0.603 rs3795763 chr1:15959977 C/T cg16988262 chr1:15930761 NA 0.34 5.48 0.32 9.82e-8 Systolic blood pressure; CESC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg03709012 chr19:19516395 GATAD2A 0.96 14.18 0.66 2.35e-34 Tonsillectomy; CESC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg14403583 chr14:105418241 AHNAK2 -0.54 -7.3 -0.41 3.35e-12 Rheumatoid arthritis; CESC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg04414720 chr1:150670196 GOLPH3L 0.55 7.08 0.4 1.27e-11 Melanoma; CESC cis rs684232 0.602 rs394747 chr17:562495 C/G cg12384639 chr17:618140 VPS53 -0.42 -5.47 -0.32 1.02e-7 Prostate cancer; CESC cis rs4523957 0.859 rs9891227 chr17:2164311 G/A cg16513277 chr17:2031491 SMG6 -0.6 -8.18 -0.45 1.22e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2073300 0.609 rs6137917 chr20:23360369 G/A cg16736954 chr20:23401023 NAPB 0.8 6.09 0.35 3.89e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1023500 0.551 rs61665536 chr22:42512613 A/G cg15557168 chr22:42548783 NA 0.45 6.51 0.37 3.78e-10 Schizophrenia; CESC cis rs8060686 0.641 rs76419201 chr16:68153553 G/A cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 5.04e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs2011503 0.941 rs2074302 chr19:19381728 G/C cg20644253 chr19:19431407 KIAA0892;SF4 0.51 5.18 0.3 4.38e-7 Bipolar disorder; CESC cis rs193541 0.632 rs39821 chr5:122295472 T/C cg19412675 chr5:122181750 SNX24 0.45 5.34 0.31 2.03e-7 Glucose homeostasis traits; CESC cis rs3956705 0.762 rs13437980 chr7:32997749 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.46 5.39 0.31 1.56e-7 Red cell distribution width; CESC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg07507251 chr3:52567010 NT5DC2 0.41 7.11 0.4 1.05e-11 Bipolar disorder; CESC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg18252515 chr7:66147081 NA 0.4 5.2 0.3 4e-7 Aortic root size; CESC cis rs11098499 0.691 rs9995716 chr4:120264996 T/C cg09307838 chr4:120376055 NA 0.75 9.88 0.52 8.38e-20 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24542046 chr7:102782124 NAPEPLD;RPL19P12 -0.49 -6.14 -0.35 3.02e-9 Gut microbiome composition (summer); CESC cis rs796364 0.616 rs6710393 chr2:200697246 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.65 6.36 0.36 9.05e-10 Schizophrenia; CESC cis rs4141404 0.757 rs5749272 chr22:31830351 C/T cg13145458 chr22:31556086 RNF185 0.49 6.07 0.35 4.33e-9 Paclitaxel-induced neuropathy; CESC cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg26677194 chr12:130822605 PIWIL1 0.53 6.98 0.39 2.31e-11 Menopause (age at onset); CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg22741997 chr17:6900356 ALOX12 -0.46 -7.12 -0.4 1.03e-11 Tonsillectomy; CESC cis rs7188697 0.922 rs37055 chr16:58560775 C/T cg02549819 chr16:58548995 SETD6 -0.42 -5.23 -0.31 3.45e-7 QT interval; CESC cis rs796364 0.568 rs11890894 chr2:201072055 C/T cg23649088 chr2:200775458 C2orf69 0.49 5.72 0.33 2.81e-8 Schizophrenia; CESC cis rs6695640 0.819 rs2762887 chr1:17731440 A/G cg01904812 chr1:17746340 RCC2 0.35 5.18 0.3 4.32e-7 Mean platelet volume; CESC cis rs1003719 0.788 rs2835584 chr21:38460338 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.68 0.47 4.19e-16 Eye color traits; CESC cis rs7582720 1.000 rs115953525 chr2:203744445 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs561341 0.883 rs1034627 chr17:30219569 C/T cg27661571 chr11:113659931 NA -0.63 -6.89 -0.39 4e-11 Hip circumference adjusted for BMI; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg00747290 chr2:42721154 KCNG3 0.48 6.02 0.35 5.88e-9 Breast cancer;Type 2 diabetes; CESC trans rs11098499 0.954 rs3733524 chr4:120423729 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.61 0.51 6.02e-19 Corneal astigmatism; CESC cis rs1878931 0.580 rs3848355 chr16:3407489 A/C cg22508957 chr16:3507546 NAT15 -0.37 -5.31 -0.31 2.31e-7 Body mass index (adult); CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg03760483 chr17:6899297 ALOX12 -0.37 -6.28 -0.36 1.4e-9 Tonsillectomy; CESC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg04518342 chr5:131593106 PDLIM4 0.41 6.21 0.36 2.08e-9 Breast cancer; CESC cis rs6964587 0.692 rs7807490 chr7:91773359 A/G cg01689657 chr7:91764605 CYP51A1 0.27 5.24 0.31 3.24e-7 Breast cancer; CESC cis rs2795502 1.000 rs2185717 chr10:43343875 G/A cg20628663 chr10:43360327 NA 0.61 7.23 0.41 5.03e-12 Blood protein levels; CESC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg19346786 chr7:2764209 NA -0.43 -6.48 -0.37 4.51e-10 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs10927875 0.722 rs6660685 chr1:16346988 A/G cg22431228 chr1:16359049 CLCNKA -0.5 -8.33 -0.46 4.4e-15 Dilated cardiomyopathy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06766273 chr11:62521983 ZBTB3 -0.48 -7.13 -0.4 9.64e-12 Gambling; CESC cis rs9467711 0.606 rs2073527 chr6:26374978 T/C cg12826209 chr6:26865740 GUSBL1 0.65 5.35 0.31 1.88e-7 Autism spectrum disorder or schizophrenia; CESC cis rs3806843 0.735 rs778596 chr5:140037272 G/A cg16179182 chr5:140090404 VTRNA1-1 0.39 5.1 0.3 6.44e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg03433033 chr1:76189801 ACADM 0.68 8.14 0.45 1.54e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg27535305 chr1:53392650 SCP2 -0.33 -5.42 -0.32 1.31e-7 Monocyte count; CESC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.73 11.64 0.58 1.46e-25 Personality dimensions; CESC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg17366294 chr4:99064904 C4orf37 0.62 8.98 0.48 5.15e-17 Colonoscopy-negative controls vs population controls; CESC cis rs79349575 0.783 rs9747646 chr17:47016882 C/T cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs2070997 0.607 rs9695221 chr9:133660295 A/G cg11464064 chr9:133710261 ABL1 0.56 6.65 0.38 1.68e-10 Response to amphetamines; CESC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs881375 0.678 rs9886724 chr9:123665019 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.66 0.43 3.56e-13 Rheumatoid arthritis; CESC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg14159672 chr1:205819179 PM20D1 0.48 6.94 0.39 3.01e-11 Menarche (age at onset); CESC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg01988459 chr11:68622903 NA -0.45 -6.43 -0.37 5.81e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg20503657 chr10:835505 NA 0.69 6.31 0.36 1.19e-9 Eosinophil percentage of granulocytes; CESC cis rs3087591 0.922 rs757383 chr17:29596045 C/G cg24425628 chr17:29625626 OMG;NF1 0.42 5.14 0.3 5.26e-7 Hip circumference; CESC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg20573242 chr4:122745356 CCNA2 0.62 7.46 0.42 1.22e-12 Type 2 diabetes; CESC cis rs9303401 0.614 rs35057477 chr17:57097064 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.98 12.37 0.61 4.77e-28 Cognitive test performance; CESC cis rs1030877 0.515 rs2679893 chr2:105909554 A/G cg02079111 chr2:105885981 TGFBRAP1 0.47 6.21 0.36 2.08e-9 Obesity-related traits; CESC cis rs5769765 0.908 rs4824109 chr22:50271460 T/C cg22709217 chr22:50311962 ALG12;CRELD2 0.44 5.07 0.3 7.31e-7 Schizophrenia; CESC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg18099408 chr3:52552593 STAB1 -0.3 -5.24 -0.31 3.35e-7 Electroencephalogram traits; CESC cis rs6728642 0.572 rs13403225 chr2:97600827 A/G cg26665480 chr2:98280029 ACTR1B -0.69 -8.45 -0.46 1.95e-15 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg14159672 chr1:205819179 PM20D1 0.68 10.79 0.55 9.86e-23 Monocyte percentage of white cells; CESC cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg22467129 chr15:76604101 ETFA -0.36 -5.48 -0.32 1e-7 Blood metabolite levels; CESC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg04756594 chr16:24857601 SLC5A11 -0.48 -5.77 -0.33 2.22e-8 Intelligence (multi-trait analysis); CESC cis rs2228479 0.850 rs17226428 chr16:89842884 T/A cg14709524 chr16:89940631 TCF25 0.9 6.7 0.38 1.25e-10 Skin colour saturation; CESC cis rs35306767 0.903 rs12778891 chr10:950130 T/A cg26597838 chr10:835615 NA 0.91 9.79 0.52 1.66e-19 Eosinophil percentage of granulocytes; CESC cis rs6912958 0.684 rs2787893 chr6:88387359 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.53 -7.08 -0.4 1.31e-11 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18767321 chr22:39096505 JOSD1 0.67 7.86 0.43 9.98e-14 Gut microbiome composition (summer); CESC trans rs561341 0.941 rs2428338 chr17:30299629 T/C cg27661571 chr11:113659931 NA -0.69 -6.97 -0.39 2.54e-11 Hip circumference adjusted for BMI; CESC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg07507251 chr3:52567010 NT5DC2 0.41 7.2 0.4 6.38e-12 Bipolar disorder; CESC cis rs12137294 0.829 rs1172154 chr1:205220639 T/G cg21643547 chr1:205240462 TMCC2 -0.34 -5.46 -0.32 1.1e-7 Red cell distribution width; CESC cis rs2204008 0.728 rs12369538 chr12:38443942 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.9 0.34 1.1e-8 Bladder cancer; CESC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg24549020 chr5:56110836 MAP3K1 0.46 5.67 0.33 3.64e-8 Initial pursuit acceleration; CESC cis rs6963495 0.818 rs73190187 chr7:105164401 A/T cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs61869271 0.871 rs6585309 chr10:116730337 A/G cg23260525 chr10:116636907 FAM160B1 -0.29 -5.21 -0.31 3.73e-7 Tonsillectomy; CESC cis rs2235642 0.592 rs743963 chr16:1657350 A/T cg03771183 chr16:1608904 IFT140 0.39 5.45 0.32 1.14e-7 Coronary artery disease; CESC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg18477163 chr1:228402036 OBSCN -0.31 -5.31 -0.31 2.31e-7 Diastolic blood pressure; CESC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.706 rs4516267 chr17:37471482 G/T cg07936489 chr17:37558343 FBXL20 0.92 10.37 0.54 2.23e-21 Glomerular filtration rate (creatinine); CESC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg16325326 chr1:53192061 ZYG11B 0.89 14.86 0.67 9.59e-37 Monocyte count; CESC cis rs67311347 1.000 rs4973989 chr3:40451543 C/T cg24209194 chr3:40518798 ZNF619 0.5 6.13 0.35 3.1e-9 Renal cell carcinoma; CESC cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg06627628 chr2:24431161 ITSN2 -0.65 -6.09 -0.35 3.92e-9 Lymphocyte counts; CESC cis rs897984 0.762 rs11150601 chr16:30977799 G/A cg02466173 chr16:30829666 NA 0.47 7.92 0.44 6.36e-14 Dementia with Lewy bodies; CESC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 6.0 0.35 6.5e-9 Electroencephalogram traits; CESC cis rs6460942 1.000 rs17668923 chr7:12302873 A/T cg02935154 chr7:12443704 VWDE -0.51 -5.53 -0.32 7.73e-8 Coronary artery disease; CESC cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg14500267 chr11:67383377 NA -0.35 -5.53 -0.32 7.74e-8 Mean corpuscular volume; CESC cis rs6032067 0.852 rs6032053 chr20:43829935 G/T cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.56e-7 Blood protein levels; CESC cis rs1552244 0.554 rs7638846 chr3:10048601 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.57 -7.44 -0.42 1.37e-12 Alzheimer's disease; CESC cis rs6665290 0.904 rs1343744 chr1:227183022 C/T cg10327440 chr1:227177885 CDC42BPA -1.17 -26.61 -0.85 8.35e-77 Myeloid white cell count; CESC cis rs763014 0.898 rs8060585 chr16:635794 C/G cg09263875 chr16:632152 PIGQ 0.68 11.61 0.58 1.81e-25 Height; CESC cis rs4849845 0.849 rs3889224 chr2:121024419 A/G cg24070213 chr2:121070622 NA 0.39 5.04 0.3 8.71e-7 Mean platelet volume; CESC cis rs611744 0.870 rs685358 chr8:109161413 T/C cg21045802 chr8:109455806 TTC35 0.47 5.8 0.34 1.92e-8 Dupuytren's disease; CESC cis rs7666738 0.830 rs6843777 chr4:98866635 T/A cg17366294 chr4:99064904 C4orf37 0.54 7.36 0.41 2.3e-12 Colonoscopy-negative controls vs population controls; CESC cis rs6714710 0.580 rs11692470 chr2:98520564 T/C cg26665480 chr2:98280029 ACTR1B 0.6 8.14 0.45 1.57e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs10791097 0.694 rs4457753 chr11:130755575 A/G cg12179176 chr11:130786555 SNX19 0.65 10.12 0.53 1.49e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg06456125 chr7:65229604 NA -0.44 -5.77 -0.33 2.23e-8 Calcium levels; CESC cis rs2635047 0.811 rs12956009 chr18:44768024 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 5.95 0.34 8.42e-9 Educational attainment; CESC trans rs1728785 1.000 rs698712 chr16:68561879 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.23 0.41 5.24e-12 Ulcerative colitis; CESC cis rs13382862 0.823 rs12710743 chr2:20880714 T/C cg12334488 chr2:20871173 GDF7 -0.37 -5.58 -0.32 5.86e-8 Abdominal aortic aneurysm; CESC cis rs1153858 1.000 rs1719247 chr15:45620985 C/T cg21132104 chr15:45694354 SPATA5L1 0.78 10.38 0.54 2.12e-21 Homoarginine levels; CESC cis rs11122272 0.735 rs2749717 chr1:231489353 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.47 -6.27 -0.36 1.48e-9 Hemoglobin concentration; CESC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.51e-24 Menopause (age at onset); CESC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.16 0.3 4.85e-7 Personality dimensions; CESC trans rs17116334 1.000 rs17116334 chr11:113961762 C/T cg12368752 chr11:117800233 TMPRSS13 0.32 6.28 0.36 1.37e-9 Conduct disorder (maternal expressed emotions interaction); CESC cis rs79387448 0.638 rs116055209 chr2:103032189 C/T cg09003973 chr2:102972529 NA 0.97 7.69 0.43 2.98e-13 Gut microbiota (bacterial taxa); CESC cis rs36051895 0.658 rs10974914 chr9:5014332 C/T cg02405213 chr9:5042618 JAK2 -0.46 -5.72 -0.33 2.82e-8 Pediatric autoimmune diseases; CESC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.61 0.42 4.95e-13 Prudent dietary pattern; CESC cis rs1003719 0.762 rs3787780 chr21:38462614 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.62 0.47 6.19e-16 Eye color traits; CESC cis rs2635047 0.638 rs16954999 chr18:44610718 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 5.53 0.32 7.48e-8 Educational attainment; CESC cis rs6967414 0.786 rs6948965 chr7:6758547 G/A cg00387323 chr7:6746715 ZNF12 0.61 5.77 0.33 2.21e-8 Hematocrit;Hemoglobin concentration; CESC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.65 0.38 1.71e-10 Prudent dietary pattern; CESC trans rs1421898 0.685 rs6556362 chr5:158157593 A/T cg19069039 chr12:52238665 NA -0.51 -6.07 -0.35 4.31e-9 Inflammatory skin disease; CESC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.02 0.8 8.62e-62 Prudent dietary pattern; CESC cis rs897984 0.609 rs17839567 chr16:31057945 A/G cg00531865 chr16:30841666 NA -0.38 -5.43 -0.32 1.29e-7 Dementia with Lewy bodies; CESC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg26338869 chr17:61819248 STRADA 0.73 9.65 0.51 4.47e-19 Prudent dietary pattern; CESC cis rs7527798 0.592 rs960088 chr1:207827067 A/C cg21110645 chr1:207815933 NA -0.33 -5.87 -0.34 1.31e-8 Erythrocyte sedimentation rate; CESC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg11764359 chr7:65958608 NA 0.74 10.72 0.55 1.66e-22 Aortic root size; CESC cis rs2243480 1.000 rs35421653 chr7:65363429 C/A cg12463550 chr7:65579703 CRCP 0.7 5.42 0.32 1.33e-7 Diabetic kidney disease; CESC cis rs910316 0.935 rs175076 chr14:75505486 A/G cg11812906 chr14:75593930 NEK9 -0.86 -14.27 -0.66 1.16e-34 Height; CESC cis rs524023 0.629 rs480617 chr11:64478320 C/T cg07220939 chr11:64358617 SLC22A12 -0.34 -5.11 -0.3 6.05e-7 Urate levels in obese individuals; CESC cis rs1538970 0.774 rs67683090 chr1:45977803 T/G cg06784218 chr1:46089804 CCDC17 0.37 5.9 0.34 1.11e-8 Platelet count; CESC cis rs2066819 1.000 rs11575232 chr12:56744422 G/A cg26734620 chr12:56694298 CS 0.98 5.94 0.34 8.73e-9 Psoriasis vulgaris; CESC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg00339695 chr16:24857497 SLC5A11 -0.49 -6.04 -0.35 5.17e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2299587 0.545 rs12543739 chr8:17756229 C/T cg08627089 chr8:17753878 FGL1 -0.38 -5.52 -0.32 8.01e-8 Economic and political preferences; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03361557 chr19:19774500 ATP13A1 0.55 6.82 0.39 6.3e-11 Gut microbiome composition (summer); CESC cis rs7264396 0.563 rs2425094 chr20:34306974 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.75 0.38 9.35e-11 Total cholesterol levels; CESC cis rs6701037 1.000 rs12747817 chr1:175118895 C/T cg00321850 chr1:175162397 KIAA0040 -0.42 -5.91 -0.34 1.02e-8 Alcohol dependence; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04013959 chr19:16739443 MED26 -0.51 -6.3 -0.36 1.21e-9 Asthma; CESC cis rs17253792 0.822 rs76264681 chr14:56060447 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs72945132 0.825 rs58532402 chr11:70189491 C/T cg14191688 chr11:70257035 CTTN 0.41 5.13 0.3 5.6e-7 Coronary artery disease; CESC cis rs761746 0.881 rs12484606 chr22:31937476 C/T cg25791279 chr22:32026902 PISD -0.52 -6.01 -0.35 6.1e-9 Intelligence; CESC cis rs9595066 0.627 rs4942287 chr13:44734696 C/T cg04068111 chr13:44716778 NA 0.4 5.59 0.33 5.51e-8 Schizophrenia; CESC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg05863683 chr7:1912471 MAD1L1 0.48 7.08 0.4 1.29e-11 Bipolar disorder and schizophrenia; CESC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg22467129 chr15:76604101 ETFA -0.37 -5.64 -0.33 4.4e-8 Blood metabolite levels; CESC cis rs36051895 0.623 rs10120337 chr9:5243511 G/A cg02405213 chr9:5042618 JAK2 -0.6 -7.21 -0.41 5.78e-12 Pediatric autoimmune diseases; CESC cis rs13191362 1.000 rs67747005 chr6:163150845 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.71 7.37 0.41 2.11e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4948102 0.731 rs7800001 chr7:56072010 T/C cg09872392 chr7:56161020 PHKG1 -0.42 -6.46 -0.37 4.96e-10 Plasma homocysteine levels (post-methionine load test); CESC cis rs6430585 0.527 rs6753232 chr2:136436317 C/T cg07169764 chr2:136633963 MCM6 -1.02 -11.43 -0.57 7.47e-25 Corneal structure; CESC cis rs3733585 0.664 rs28602527 chr4:9958327 G/A cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs763121 0.819 rs5750658 chr22:39060917 C/T cg14440974 chr22:39074834 NA -0.4 -5.5 -0.32 9.03e-8 Menopause (age at onset); CESC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg01988459 chr11:68622903 NA -0.4 -5.25 -0.31 3.13e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13095912 0.925 rs11924016 chr3:185307879 A/T cg11274856 chr3:185301563 NA 0.37 5.83 0.34 1.57e-8 Systolic blood pressure; CESC trans rs7672847 0.547 rs72974775 chr4:170524429 G/C cg19308436 chr1:237949471 RYR2 0.57 6.33 0.36 1.04e-9 Subjective well-being; CESC cis rs9393777 0.623 rs9358948 chr6:26483806 G/A cg12826209 chr6:26865740 GUSBL1 0.65 6.85 0.39 5.16e-11 Intelligence (multi-trait analysis); CESC cis rs3008870 1.000 rs2815351 chr1:67477980 A/G cg02640540 chr1:67518911 SLC35D1 0.48 5.27 0.31 2.77e-7 Lymphocyte percentage of white cells; CESC cis rs4588572 0.643 rs1560195 chr5:77701913 A/G cg11547950 chr5:77652471 NA 0.46 5.95 0.34 8.49e-9 Triglycerides; CESC cis rs7762018 1.000 rs6904601 chr6:170131905 T/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.58 6.0 0.35 6.55e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs589448 0.538 rs622656 chr12:69753595 C/T cg20891283 chr12:69753455 YEATS4 0.77 10.24 0.53 5.78e-21 Cerebrospinal fluid biomarker levels; CESC cis rs4888262 0.545 rs7193959 chr16:74664969 T/A cg01733217 chr16:74700730 RFWD3 0.92 12.54 0.61 1.21e-28 Testicular germ cell tumor; CESC cis rs2243480 1.000 rs7795242 chr7:65390094 T/C cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs12477438 0.520 rs7605843 chr2:99811894 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.91 15.7 0.69 1.04e-39 Chronic sinus infection; CESC cis rs10751667 0.714 rs7933889 chr11:972270 C/T cg06064525 chr11:970664 AP2A2 -0.47 -9.13 -0.49 1.87e-17 Alzheimer's disease (late onset); CESC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg24829409 chr8:58192753 C8orf71 -0.62 -8.39 -0.46 3.01e-15 Developmental language disorder (linguistic errors); CESC cis rs1348850 0.519 rs4144275 chr2:178523368 C/T cg22681709 chr2:178499509 PDE11A -0.49 -7.08 -0.4 1.29e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26547359 chr10:16859530 RSU1 0.68 8.08 0.44 2.33e-14 Gut microbiome composition (summer); CESC cis rs12530845 1.000 rs77068811 chr7:135334571 A/G cg23117316 chr7:135346802 PL-5283 -0.4 -5.15 -0.3 4.98e-7 Red blood cell traits; CESC cis rs13266463 0.830 rs7014552 chr8:143410423 A/G cg06454464 chr8:143427921 TSNARE1 0.4 5.27 0.31 2.8e-7 Schizophrenia; CESC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg18230493 chr5:56204884 C5orf35 0.61 8.27 0.45 6.7e-15 Initial pursuit acceleration; CESC cis rs2777491 0.957 rs6493002 chr15:41709195 C/G cg20272979 chr15:41787780 ITPKA 0.45 6.66 0.38 1.54e-10 Ulcerative colitis; CESC cis rs9902453 0.934 rs7211246 chr17:28485762 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.67 0.43 3.35e-13 Coffee consumption (cups per day); CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg16618282 chr3:47018402 CCDC12 0.42 6.03 0.35 5.41e-9 Positive affect; CESC cis rs7618501 1.000 rs11130219 chr3:49752427 C/T cg24308560 chr3:49941425 MST1R 0.5 6.94 0.39 3.08e-11 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg03467027 chr4:99064603 C4orf37 0.48 6.21 0.36 2.02e-9 Colonoscopy-negative controls vs population controls; CESC cis rs57083693 0.536 rs10745911 chr12:101695105 T/C cg22051763 chr12:101673672 UTP20 -0.44 -5.5 -0.32 8.8e-8 Alcohol dependence (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16242888 chr9:34179479 UBAP1 -0.45 -6.42 -0.37 6.37e-10 Gambling; CESC cis rs7906315 0.967 rs3814573 chr10:114898093 C/T cg14665389 chr10:114710815 TCF7L2 0.45 5.36 0.31 1.78e-7 Breast cancer; CESC cis rs11785400 1.000 rs6997670 chr8:143737915 G/A cg24634471 chr8:143751801 JRK 0.47 6.21 0.36 2e-9 Schizophrenia; CESC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg26587870 chr6:27730563 NA 0.43 5.57 0.32 6.12e-8 Parkinson's disease; CESC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg23281280 chr6:28129359 ZNF389 0.43 6.41 0.37 6.55e-10 Cardiac Troponin-T levels; CESC cis rs4423214 0.959 rs12793224 chr11:71168710 G/A cg05163923 chr11:71159392 DHCR7 0.77 10.41 0.54 1.69e-21 Vitamin D levels; CESC trans rs3942852 0.524 rs7118665 chr11:48078427 C/A cg15704280 chr7:45808275 SEPT13 0.77 9.66 0.51 4.23e-19 Acute lymphoblastic leukemia (childhood); CESC cis rs7091068 0.616 rs10748611 chr10:95482761 A/C cg20715218 chr10:95462985 C10orf4 0.5 5.29 0.31 2.5e-7 Urinary tract infection frequency; CESC cis rs4409675 0.576 rs6564 chr1:28212975 A/G cg23691781 chr1:28212827 C1orf38 -0.29 -5.69 -0.33 3.31e-8 Corneal astigmatism; CESC cis rs863345 0.584 rs1342949 chr1:158463295 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs926392 0.572 rs6129157 chr20:37672247 G/T cg16355469 chr20:37678765 NA 0.54 6.53 0.37 3.31e-10 Dialysis-related mortality; CESC cis rs5167 0.506 rs11669173 chr19:45492559 G/A cg09555818 chr19:45449301 APOC2 -0.44 -6.55 -0.37 2.92e-10 Blood protein levels; CESC cis rs11676348 0.846 rs4674257 chr2:218988774 A/G cg00012203 chr2:219082015 ARPC2 -0.56 -7.31 -0.41 3.19e-12 Ulcerative colitis; CESC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Parkinson's disease; CESC cis rs1577917 0.958 rs12207374 chr6:86656645 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.86 -0.34 1.4e-8 Response to antipsychotic treatment; CESC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.85 -10.36 -0.54 2.52e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg05483915 chr17:80145575 CCDC57 0.43 5.23 0.31 3.48e-7 Breast cancer; CESC cis rs1348850 0.872 rs4893959 chr2:178400204 G/A cg23306229 chr2:178417860 TTC30B 0.63 7.84 0.43 1.08e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs13082711 0.911 rs11718991 chr3:27452944 A/G cg02860705 chr3:27208620 NA 0.59 7.39 0.41 1.94e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs4450798 0.739 rs3856823 chr3:13742350 A/G cg05589046 chr3:13742034 LOC285375 0.34 5.47 0.32 1.05e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1707322 0.682 rs3014241 chr1:46087879 A/G cg03146154 chr1:46216737 IPP -0.81 -11.24 -0.57 3.26e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03389907 chr1:54954187 NA -0.42 -6.06 -0.35 4.72e-9 Gambling; CESC cis rs3845702 0.736 rs72958863 chr2:180808144 C/T cg01881094 chr2:180872142 CWC22 1.04 8.75 0.47 2.56e-16 Schizophrenia; CESC cis rs478304 0.651 rs948494 chr11:65552118 G/A cg27068330 chr11:65405492 SIPA1 -0.48 -5.76 -0.33 2.32e-8 Acne (severe); CESC cis rs62432291 0.681 rs431205 chr6:159662499 A/G cg14500486 chr6:159655392 FNDC1 -0.58 -5.82 -0.34 1.69e-8 Joint mobility (Beighton score); CESC cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.71 8.96 0.48 5.78e-17 Multiple sclerosis; CESC trans rs4332037 0.539 rs3823624 chr7:2110346 T/C cg11693508 chr17:37793320 STARD3 0.67 6.79 0.38 7.32e-11 Bipolar disorder; CESC cis rs9457247 1.000 rs2757047 chr6:167374489 C/T cg07741184 chr6:167504864 NA -0.3 -5.44 -0.32 1.19e-7 Crohn's disease; CESC trans rs6499129 0.571 rs9940665 chr16:67289841 C/T cg17013778 chr10:135130084 NA -0.75 -6.17 -0.35 2.56e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1215050 0.791 rs165241 chr4:98681112 C/T cg05340658 chr4:99064831 C4orf37 0.47 6.04 0.35 5.08e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1878931 0.535 rs10852706 chr16:3412582 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.73 9.08 0.49 2.54e-17 Body mass index (adult); CESC cis rs12200560 0.505 rs4839849 chr6:97076673 T/C cg06623918 chr6:96969491 KIAA0776 0.5 6.42 0.37 6.42e-10 Coronary heart disease; CESC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg05340658 chr4:99064831 C4orf37 0.81 12.59 0.61 8.13e-29 Colonoscopy-negative controls vs population controls; CESC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg07308232 chr7:1071921 C7orf50 -0.59 -8.46 -0.46 1.88e-15 Longevity;Endometriosis; CESC cis rs8180040 0.726 rs4682844 chr3:46982737 T/C cg27129171 chr3:47204927 SETD2 -0.64 -9.04 -0.49 3.43e-17 Colorectal cancer; CESC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.7 0.38 1.23e-10 Bipolar disorder; CESC cis rs4604732 0.631 rs76761880 chr1:247626377 T/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg06108461 chr20:60628389 TAF4 -0.84 -12.48 -0.61 1.92e-28 Body mass index; CESC cis rs7107174 1.000 rs1318241 chr11:77930792 C/T cg02023728 chr11:77925099 USP35 0.52 6.68 0.38 1.38e-10 Testicular germ cell tumor; CESC cis rs6424115 0.965 rs2502986 chr1:24135292 G/T cg15997130 chr1:24165203 NA 0.43 5.94 0.34 9.1e-9 Immature fraction of reticulocytes; CESC cis rs2991971 0.810 rs2036021 chr1:45901370 G/A cg24296786 chr1:45957014 TESK2 0.59 8.38 0.46 3.24e-15 High light scatter reticulocyte count; CESC cis rs7818688 1.000 rs28378156 chr8:96027127 C/T cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12506980 chr3:20227397 SGOL1 -0.47 -6.32 -0.36 1.07e-9 Gut microbiota (bacterial taxa); CESC cis rs4835473 0.932 rs11721700 chr4:144745417 G/C cg25736465 chr4:144833511 NA -0.35 -5.43 -0.32 1.28e-7 Immature fraction of reticulocytes; CESC cis rs10504229 0.679 rs16921687 chr8:58053514 T/C cg24829409 chr8:58192753 C8orf71 -0.5 -6.27 -0.36 1.43e-9 Developmental language disorder (linguistic errors); CESC cis rs9899728 0.539 rs12938889 chr17:73039929 A/C cg27626185 chr17:73056755 KCTD2 0.97 8.53 0.46 1.14e-15 Alzheimer's disease or small vessel stroke; CESC cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg05283184 chr6:79620031 NA -0.43 -6.56 -0.37 2.85e-10 Intelligence (multi-trait analysis); CESC cis rs17253792 0.822 rs113350960 chr14:56087713 G/A cg01858014 chr14:56050164 KTN1 -0.83 -7.03 -0.4 1.7e-11 Putamen volume; CESC cis rs2072732 0.861 rs77840846 chr1:2968983 G/C cg15211996 chr1:2936768 ACTRT2 0.33 5.21 0.3 3.74e-7 Plateletcrit; CESC trans rs1814175 0.935 rs28586931 chr11:49693872 G/A cg03929089 chr4:120376271 NA -0.87 -13.35 -0.63 1.93e-31 Height; CESC cis rs854765 0.647 rs2974998 chr17:17995619 A/G cg16928487 chr17:17741425 SREBF1 -0.53 -8.7 -0.47 3.48e-16 Total body bone mineral density; CESC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg22963979 chr7:1858916 MAD1L1 -0.38 -5.27 -0.31 2.81e-7 Bipolar disorder and schizophrenia; CESC cis rs7772486 0.790 rs6917135 chr6:146152426 T/C cg05347473 chr6:146136440 FBXO30 0.55 7.26 0.41 4.4e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9443645 0.869 rs10943585 chr6:79502409 G/C cg05283184 chr6:79620031 NA -0.43 -6.67 -0.38 1.52e-10 Intelligence (multi-trait analysis); CESC cis rs4604732 0.631 rs12039642 chr1:247624898 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg06420487 chr17:61919686 SMARCD2 0.48 5.54 0.32 7.15e-8 Height; CESC cis rs854765 0.693 rs9907287 chr17:17774118 C/T cg16928487 chr17:17741425 SREBF1 0.55 9.59 0.51 7.06e-19 Total body bone mineral density; CESC cis rs3008870 0.755 rs10749766 chr1:67376921 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.64 8.41 0.46 2.52e-15 Lymphocyte percentage of white cells; CESC cis rs13256369 0.826 rs7846050 chr8:8575669 A/G cg18904891 chr8:8559673 CLDN23 0.67 7.92 0.44 6.42e-14 Obesity-related traits; CESC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg23131131 chr22:24373011 LOC391322 -0.69 -9.69 -0.51 3.38e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9858542 0.953 rs9827021 chr3:49514764 C/A cg03060546 chr3:49711283 APEH -0.55 -6.28 -0.36 1.34e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg18876405 chr7:65276391 NA -0.53 -7.27 -0.41 4.11e-12 Aortic root size; CESC cis rs208520 0.690 rs12202805 chr6:66703903 A/G cg07460842 chr6:66804631 NA -0.94 -13.0 -0.62 3.26e-30 Exhaled nitric oxide output; CESC cis rs1797081 0.542 rs2603796 chr10:16871456 C/T cg23933602 chr10:16859644 RSU1 0.72 10.3 0.53 3.93e-21 Platelet distribution width; CESC cis rs2425143 1.000 rs17093026 chr20:34318911 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.73 6.78 0.38 7.95e-11 Blood protein levels; CESC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg18402987 chr7:1209562 NA 0.75 7.5 0.42 9.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11122272 0.701 rs2790887 chr1:231523724 G/C cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7542091 0.635 rs985431 chr1:210043948 A/T cg09509183 chr1:209979624 IRF6 0.4 5.78 0.33 2.12e-8 Monobrow; CESC cis rs1348850 0.574 rs4893834 chr2:178442288 C/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.52 -5.13 -0.3 5.66e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7089973 0.624 rs17586888 chr10:116598121 T/C cg25233709 chr10:116636983 FAM160B1 0.38 5.97 0.34 7.44e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9905704 0.718 rs193391 chr17:56672944 T/C cg12560992 chr17:57184187 TRIM37 0.64 5.98 0.34 7.36e-9 Testicular germ cell tumor; CESC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg25204440 chr1:209979598 IRF6 0.65 6.65 0.38 1.67e-10 Cleft lip with or without cleft palate; CESC cis rs11785400 1.000 rs4736342 chr8:143735190 A/G cg10596483 chr8:143751796 JRK 0.43 5.51 0.32 8.49e-8 Schizophrenia; CESC cis rs7786877 0.723 rs11764045 chr7:100212754 C/T cg16850897 chr7:100343110 ZAN -0.56 -5.87 -0.34 1.29e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs16958440 1.000 rs60228288 chr18:44640412 G/A cg19380001 chr1:50889427 DMRTA2 -0.88 -6.07 -0.35 4.47e-9 Sitting height ratio; CESC cis rs4971059 0.654 rs10157801 chr1:155120012 A/G cg22049894 chr1:155113146 DPM3 0.43 5.68 0.33 3.5e-8 Breast cancer; CESC cis rs7772486 0.686 rs9403746 chr6:146103768 C/A cg05347473 chr6:146136440 FBXO30 -0.53 -6.93 -0.39 3.25e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs72781680 0.898 rs72788214 chr2:24087621 A/C cg20701182 chr2:24300061 SF3B14 0.62 5.68 0.33 3.54e-8 Lymphocyte counts; CESC cis rs11168618 0.626 rs11514105 chr12:48820934 G/C cg24011408 chr12:48396354 COL2A1 0.36 5.53 0.32 7.49e-8 Adiponectin levels; CESC cis rs7580658 0.864 rs4150454 chr2:128038544 T/C cg10021288 chr2:128175891 PROC -0.39 -6.24 -0.36 1.74e-9 Protein C levels; CESC cis rs807669 0.869 rs1061325 chr22:19184095 T/C cg02655711 chr22:19163373 SLC25A1 0.44 6.76 0.38 8.99e-11 Metabolite levels; CESC cis rs7833986 0.501 rs2976012 chr8:56974343 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 6.89e-13 Height; CESC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg14829155 chr15:31115871 NA 0.72 10.47 0.54 1.05e-21 Huntington's disease progression; CESC trans rs11148252 0.532 rs9536185 chr13:53179801 G/A cg18335740 chr13:41363409 SLC25A15 0.56 7.46 0.42 1.27e-12 Lewy body disease; CESC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg01238044 chr22:24384105 GSTT1 -0.51 -6.42 -0.37 6.25e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1448094 0.817 rs11117115 chr12:86331021 A/G cg02569458 chr12:86230093 RASSF9 0.45 6.43 0.37 5.79e-10 Major depressive disorder; CESC cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg23649088 chr2:200775458 C2orf69 0.74 9.34 0.5 4.04e-18 Osteoporosis; CESC cis rs17376456 0.825 rs10064368 chr5:93266396 C/A cg21475434 chr5:93447410 FAM172A 0.74 6.16 0.35 2.67e-9 Diabetic retinopathy; CESC cis rs116095464 0.558 rs6962 chr5:256509 G/A cg22857025 chr5:266934 NA -1.28 -15.48 -0.69 6.35e-39 Breast cancer; CESC cis rs727505 0.954 rs1383748 chr7:124638201 A/T cg23710748 chr7:124431027 NA -0.44 -6.9 -0.39 3.88e-11 Lewy body disease; CESC cis rs2898681 0.642 rs11538878 chr4:53728524 T/C cg21521518 chr4:53727714 RASL11B 0.36 5.17 0.3 4.6e-7 Optic nerve measurement (cup area); CESC cis rs9488822 0.651 rs3798228 chr6:116321156 T/C cg05304507 chr6:116381966 FRK 0.26 6.56 0.37 2.82e-10 Cholesterol, total;LDL cholesterol; CESC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg02071572 chr4:1403502 NA -0.37 -5.69 -0.33 3.36e-8 Longevity; CESC cis rs7267979 0.844 rs6076343 chr20:25376663 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -14.54 -0.67 1.28e-35 Liver enzyme levels (alkaline phosphatase); CESC cis rs761746 0.960 rs5753686 chr22:31947948 G/A cg25791279 chr22:32026902 PISD 0.49 5.61 0.33 5.09e-8 Intelligence; CESC cis rs916888 0.773 rs199439 chr17:44793503 A/G cg27589368 chr17:43923255 LOC100128977;IMP5 -0.38 -5.26 -0.31 3.01e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg16132339 chr22:24313637 DDTL;DDT 0.41 6.35 0.36 9.31e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10871290 0.650 rs12600126 chr16:74489732 A/T cg01733217 chr16:74700730 RFWD3 -0.69 -9.37 -0.5 3.29e-18 Breast cancer; CESC cis rs8114671 0.586 rs6087634 chr20:33413809 G/A cg08999081 chr20:33150536 PIGU 0.39 5.41 0.32 1.4e-7 Height; CESC trans rs1373453 0.808 rs77141535 chr12:70070304 T/G cg19702771 chr4:82058885 PRKG2 0.75 6.12 0.35 3.4e-9 Orofacial clefts; CESC cis rs7336332 0.569 rs7988412 chr13:28000282 C/T cg22138327 chr13:27999177 GTF3A 0.66 6.48 0.37 4.53e-10 Weight; CESC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg18538332 chr22:24372958 LOC391322 -0.71 -10.2 -0.53 7.94e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg03576123 chr11:487126 PTDSS2 -1.08 -10.51 -0.54 7.9e-22 Body mass index; CESC cis rs367943 0.698 rs7728525 chr5:112972215 C/G cg12552261 chr5:112820674 MCC 0.44 5.63 0.33 4.63e-8 Type 2 diabetes; CESC cis rs6831352 0.879 rs1984362 chr4:100070973 G/A cg12011299 chr4:100065546 ADH4 -0.56 -6.0 -0.35 6.4e-9 Alcohol dependence; CESC cis rs4699052 0.662 rs6825489 chr4:104250184 T/C cg16532752 chr4:104119610 CENPE -0.41 -5.85 -0.34 1.44e-8 Testicular germ cell tumor; CESC cis rs962856 0.575 rs644032 chr2:67659656 C/A cg09028215 chr2:67624308 ETAA1 -0.41 -5.06 -0.3 7.68e-7 Pancreatic cancer; CESC cis rs854765 0.618 rs9908017 chr17:17774422 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.73 -0.38 1.02e-10 Total body bone mineral density; CESC cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg05585544 chr11:47624801 NA -0.48 -7.04 -0.4 1.67e-11 Subjective well-being; CESC trans rs2727020 0.757 rs7924526 chr11:49267043 G/A cg03929089 chr4:120376271 NA 0.75 9.68 0.51 3.66e-19 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18732869 chr19:6739680 TRIP10 0.58 6.72 0.38 1.14e-10 Gut microbiome composition (summer); CESC cis rs4253772 1.000 rs4253772 chr22:46627603 C/T cg00784671 chr22:46762841 CELSR1 -0.56 -5.06 -0.3 8.02e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 7.08 0.4 1.28e-11 Platelet count; CESC cis rs7264396 1.000 rs224418 chr20:34142527 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -7.04 -0.4 1.65e-11 Total cholesterol levels; CESC trans rs4950322 0.580 rs4950371 chr1:146585825 C/T cg04954894 chr8:38089920 DDHD2 -0.58 -6.12 -0.35 3.31e-9 Protein quantitative trait loci; CESC cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg24578937 chr1:2090814 PRKCZ 0.33 5.87 0.34 1.31e-8 Height; CESC cis rs2635047 0.967 rs12960378 chr18:44614090 A/C cg19077165 chr18:44547161 KATNAL2 -0.48 -6.64 -0.38 1.78e-10 Educational attainment; CESC cis rs929354 0.772 rs3802117 chr7:156987000 C/T cg05182265 chr7:156933206 UBE3C -0.51 -7.5 -0.42 9.58e-13 Body mass index; CESC cis rs9910055 0.530 rs2269906 chr17:42294337 G/T cg13607699 chr17:42295918 UBTF -0.8 -12.25 -0.6 1.23e-27 Total body bone mineral density; CESC cis rs9287719 0.967 rs6721739 chr2:10751246 G/T cg00105475 chr2:10696890 NA -0.38 -5.48 -0.32 9.71e-8 Prostate cancer; CESC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg27125505 chr17:43679177 LOC644172 0.47 6.14 0.35 3.08e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1538970 0.962 rs7544178 chr1:45819069 C/T cg05343316 chr1:45956843 TESK2 0.81 11.05 0.56 1.38e-23 Platelet count; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg08946332 chr17:6899888 ALOX12 -0.47 -6.59 -0.38 2.42e-10 Tonsillectomy; CESC cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg11812906 chr14:75593930 NEK9 0.86 13.72 0.64 9.57e-33 Height; CESC cis rs9359856 0.564 rs72915903 chr6:90420190 A/C cg13799429 chr6:90582589 CASP8AP2 -0.66 -6.62 -0.38 1.95e-10 Bipolar disorder; CESC cis rs6433857 0.594 rs736019 chr2:181526568 A/C cg23363182 chr2:181467187 NA 0.44 6.12 0.35 3.43e-9 Body mass index; CESC cis rs3820068 0.581 rs2861387 chr1:15951296 G/A cg16988262 chr1:15930761 NA 0.33 5.21 0.31 3.73e-7 Systolic blood pressure; CESC cis rs6460942 0.915 rs6460907 chr7:12304449 G/A cg20607287 chr7:12443886 VWDE -0.41 -5.96 -0.34 7.94e-9 Coronary artery disease; CESC cis rs2710642 0.821 rs2710639 chr2:63138963 C/T cg17519650 chr2:63277830 OTX1 0.45 5.52 0.32 8.2e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs9611565 0.592 rs80477 chr22:42001183 C/T cg17376030 chr22:41985996 PMM1 -0.5 -5.48 -0.32 1.01e-7 Vitiligo; CESC cis rs9303401 0.615 rs35288118 chr17:56600748 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.98 11.09 0.56 1.02e-23 Cognitive test performance; CESC cis rs6912958 0.935 rs2179844 chr6:88165773 C/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.3 -0.31 2.44e-7 Monocyte percentage of white cells; CESC cis rs950169 1.000 rs12915234 chr15:84758301 G/A cg17507749 chr15:85114479 UBE2QP1 0.64 7.04 0.4 1.64e-11 Schizophrenia; CESC cis rs887829 0.569 rs4663963 chr2:234650193 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.5 -6.58 -0.37 2.54e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs9926296 0.656 rs2376881 chr16:89827011 C/G cg27121462 chr16:89883253 FANCA 0.54 6.6 0.38 2.26e-10 Vitiligo; CESC trans rs3780486 0.846 rs10813954 chr9:33137596 A/C cg20290983 chr6:43655470 MRPS18A 0.98 18.17 0.74 1.8e-48 IgG glycosylation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05673432 chr3:15919505 NA 0.51 6.56 0.37 2.75e-10 Fibrinogen levels; CESC cis rs965469 1.000 rs6051708 chr20:3262493 A/G cg25506879 chr20:3388711 C20orf194 -0.57 -5.88 -0.34 1.24e-8 IFN-related cytopenia; CESC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.15 -0.3 5.15e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7772486 0.712 rs6570726 chr6:146159460 T/C cg05347473 chr6:146136440 FBXO30 0.46 6.48 0.37 4.39e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9291683 0.588 rs3756236 chr4:10013463 T/A cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.16e-46 Bone mineral density; CESC cis rs9811920 0.809 rs7649349 chr3:99725629 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -7.99 -0.44 4.26e-14 Axial length; CESC cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg08508325 chr11:3079039 CARS -0.57 -10.83 -0.55 7.32e-23 Longevity; CESC cis rs7188861 0.768 rs1646025 chr16:11379938 A/G cg01510278 chr16:11456238 NA 0.34 5.23 0.31 3.45e-7 HDL cholesterol; CESC cis rs4664308 0.618 rs17830940 chr2:160891768 T/C cg03641300 chr2:160917029 PLA2R1 -0.59 -8.54 -0.46 1.04e-15 Idiopathic membranous nephropathy; CESC cis rs561341 1.000 rs550264 chr17:30317540 G/T cg00745463 chr17:30367425 LRRC37B -0.8 -7.25 -0.41 4.55e-12 Hip circumference adjusted for BMI; CESC cis rs36051895 0.632 rs10118930 chr9:5148278 C/T cg02405213 chr9:5042618 JAK2 -0.53 -6.79 -0.39 7.2e-11 Pediatric autoimmune diseases; CESC cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs36051895 0.593 rs12340303 chr9:5176147 C/T cg02405213 chr9:5042618 JAK2 -0.51 -6.5 -0.37 4.02e-10 Pediatric autoimmune diseases; CESC cis rs9911578 0.967 rs4932693 chr17:57110327 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.04 -0.3 8.43e-7 Intelligence (multi-trait analysis); CESC cis rs2243480 0.803 rs35480979 chr7:65357084 A/G cg12463550 chr7:65579703 CRCP 0.68 5.73 0.33 2.72e-8 Diabetic kidney disease; CESC cis rs1256061 0.654 rs1256033 chr14:64745399 A/G cg23250157 chr14:64679961 SYNE2 0.47 6.63 0.38 1.88e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs4664293 1.000 rs6745766 chr2:160454795 G/A cg08347373 chr2:160653686 CD302 -0.34 -5.47 -0.32 1.06e-7 Monocyte percentage of white cells; CESC cis rs11608355 0.515 rs12822282 chr12:109923207 G/A cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs9818941 0.824 rs1574064 chr3:157801204 C/G cg08654915 chr3:157813417 NA -0.43 -7.34 -0.41 2.58e-12 Height; CESC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg02569458 chr12:86230093 RASSF9 0.52 7.41 0.41 1.67e-12 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10226922 chr1:153895448 GATAD2B 0.54 6.16 0.35 2.67e-9 Gut microbiome composition (summer); CESC cis rs8114671 0.836 rs2038504 chr20:33648187 T/C cg06115741 chr20:33292138 TP53INP2 -0.43 -5.15 -0.3 5.03e-7 Height; CESC cis rs2236918 0.710 rs1776159 chr1:242018583 C/G cg17736920 chr1:242011382 EXO1 0.56 7.16 0.4 8.01e-12 Menopause (age at onset); CESC cis rs9399137 0.507 rs7768278 chr6:135274957 T/C cg22676075 chr6:135203613 NA 0.53 6.83 0.39 5.83e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs116095464 0.558 rs7736600 chr5:231337 A/C cg22857025 chr5:266934 NA -1.28 -18.2 -0.75 1.47e-48 Breast cancer; CESC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg12463550 chr7:65579703 CRCP -0.45 -5.72 -0.33 2.86e-8 Aortic root size; CESC cis rs208520 0.690 rs1885100 chr6:66871047 C/G cg07460842 chr6:66804631 NA -0.99 -13.52 -0.64 4.76e-32 Exhaled nitric oxide output; CESC cis rs73019876 0.901 rs2666453 chr19:22129287 A/G cg11619707 chr19:22235551 ZNF257 -0.29 -5.45 -0.32 1.15e-7 Testicular germ cell tumor; CESC cis rs919433 0.750 rs788012 chr2:198229856 A/T cg20885578 chr2:198174922 NA 0.4 5.2 0.3 4.09e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg09359103 chr1:154839909 KCNN3 -0.65 -12.31 -0.6 7.76e-28 Prostate cancer; CESC cis rs9911578 0.835 rs10853006 chr17:56489076 G/A cg05425664 chr17:57184151 TRIM37 0.46 6.35 0.36 9.56e-10 Intelligence (multi-trait analysis); CESC cis rs8112211 0.834 rs3178327 chr19:38798086 T/C cg14299480 chr19:38876666 GGN -0.38 -5.1 -0.3 6.56e-7 Blood protein levels; CESC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg07092213 chr7:1199455 ZFAND2A -0.48 -5.04 -0.3 8.48e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01085137 chr16:48278085 LONP2 -0.45 -6.05 -0.35 4.9e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11098499 0.954 rs11734241 chr4:120416872 A/G cg09307838 chr4:120376055 NA 0.93 13.06 0.63 2.03e-30 Corneal astigmatism; CESC cis rs1008375 0.932 rs6814465 chr4:17659034 C/T cg02297831 chr4:17616191 MED28 0.63 8.03 0.44 3.3e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6088580 0.570 rs6058057 chr20:33065283 G/A cg06115741 chr20:33292138 TP53INP2 0.47 6.09 0.35 4.03e-9 Glomerular filtration rate (creatinine); CESC cis rs735396 0.770 rs2464196 chr12:121435427 G/A cg02403541 chr12:121454288 C12orf43 0.73 10.33 0.54 2.99e-21 N-glycan levels; CESC cis rs4718428 0.705 rs4717331 chr7:66378886 C/T cg18252515 chr7:66147081 NA -0.45 -5.09 -0.3 6.82e-7 Corneal structure; CESC cis rs12477438 0.765 rs7605734 chr2:99644068 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05904283 chr16:716021 WDR90 0.46 6.26 0.36 1.56e-9 Fibrinogen levels; CESC cis rs17021463 0.555 rs7664979 chr4:95325397 A/G cg11021082 chr4:95130006 SMARCAD1 -0.43 -5.82 -0.34 1.65e-8 Testicular germ cell tumor; CESC cis rs10791097 0.703 rs11222360 chr11:130730871 C/T cg09137382 chr11:130731461 NA 0.39 5.99 0.35 6.65e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9549367 0.713 rs2146750 chr13:113822530 A/G cg00898013 chr13:113819073 PROZ 0.45 6.0 0.35 6.52e-9 Platelet distribution width; CESC cis rs9612 1.000 rs8105041 chr19:44258458 A/G cg08581076 chr19:44259116 C19orf61 0.52 6.19 0.36 2.33e-9 Exhaled nitric oxide output; CESC cis rs9389248 0.690 rs6569982 chr6:135256495 C/G cg24558204 chr6:135376177 HBS1L 0.66 9.54 0.51 9.64e-19 High light scatter reticulocyte percentage of red cells; CESC cis rs1707322 1.000 rs785467 chr1:46521559 A/T cg05343316 chr1:45956843 TESK2 -0.49 -5.89 -0.34 1.19e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8018808 0.935 rs11159263 chr14:77930188 G/C cg20045696 chr14:77926864 AHSA1 0.43 5.9 0.34 1.13e-8 Myeloid white cell count; CESC cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg10645314 chr2:3704589 ALLC -0.46 -5.09 -0.3 6.83e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg14562523 chr21:43528734 C21orf128;UMODL1 -0.4 -5.78 -0.33 2.08e-8 IgG glycosylation; CESC cis rs2742234 0.518 rs2505514 chr10:43633248 A/G cg07801480 chr10:43725741 RASGEF1A 0.44 5.51 0.32 8.67e-8 Hirschsprung disease; CESC cis rs5753037 0.754 rs41158 chr22:30405983 A/G cg01021169 chr22:30184971 ASCC2 -0.37 -5.8 -0.34 1.84e-8 Type 1 diabetes; CESC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg07691484 chr11:842764 TSPAN4;POLR2L -0.69 -9.14 -0.49 1.68e-17 Mean platelet volume; CESC cis rs977987 0.778 rs4888426 chr16:75476451 G/A cg03315344 chr16:75512273 CHST6 0.43 6.13 0.35 3.23e-9 Dupuytren's disease; CESC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg17971929 chr21:40555470 PSMG1 -0.58 -7.4 -0.41 1.79e-12 Menarche (age at onset); CESC cis rs4268898 1.000 rs10165445 chr2:24441698 C/T cg20701182 chr2:24300061 SF3B14 -0.43 -5.28 -0.31 2.67e-7 Asthma; CESC cis rs72945132 0.769 rs3781645 chr11:70190374 T/C cg00319359 chr11:70116639 PPFIA1 0.71 6.87 0.39 4.68e-11 Coronary artery disease; CESC cis rs265548 0.646 rs36692 chr19:17906839 C/T cg16024904 chr19:17905718 B3GNT3 0.41 5.55 0.32 6.96e-8 Tumor biomarkers; CESC cis rs9457247 0.663 rs12526548 chr6:167431147 C/T cg23791538 chr6:167370224 RNASET2 -0.54 -7.26 -0.41 4.27e-12 Crohn's disease; CESC cis rs854765 0.927 rs12943914 chr17:17980671 A/G cg04398451 chr17:18023971 MYO15A -0.65 -9.38 -0.5 3.06e-18 Total body bone mineral density; CESC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg18337363 chr3:52569053 NT5DC2 0.29 5.29 0.31 2.62e-7 Bipolar disorder; CESC cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg17366294 chr4:99064904 C4orf37 0.6 8.29 0.45 5.78e-15 Colonoscopy-negative controls vs population controls; CESC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg09323728 chr8:95962352 TP53INP1 -0.43 -9.53 -0.51 1.07e-18 Type 2 diabetes; CESC cis rs858239 0.539 rs3950345 chr7:23191114 T/C cg23682824 chr7:23144976 KLHL7 0.51 6.77 0.38 8.05e-11 Cerebrospinal fluid biomarker levels; CESC cis rs73206853 0.764 rs73205079 chr12:110599953 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.62 0.33 4.79e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9325144 0.534 rs1843887 chr12:38692380 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.76 0.47 2.33e-16 Morning vs. evening chronotype; CESC cis rs6952808 0.578 rs6949478 chr7:1841342 A/G cg04267008 chr7:1944627 MAD1L1 0.45 5.17 0.3 4.53e-7 Bipolar disorder and schizophrenia; CESC cis rs2242116 0.592 rs2290545 chr3:46967040 C/T cg27129171 chr3:47204927 SETD2 0.47 5.31 0.31 2.36e-7 Birth weight; CESC cis rs8077577 0.895 rs16960983 chr17:18104568 A/T cg16794390 chr17:18148240 FLII 0.38 5.12 0.3 5.95e-7 Obesity-related traits; CESC cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs748404 0.697 rs530188 chr15:43545314 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.51 8.01 0.44 3.59e-14 Lung cancer; CESC cis rs8077889 1.000 rs17742905 chr17:41891143 C/A cg26893861 chr17:41843967 DUSP3 0.82 9.77 0.51 1.89e-19 Triglycerides; CESC cis rs9916302 0.707 rs11078903 chr17:37631924 G/A cg15445000 chr17:37608096 MED1 0.41 6.77 0.38 8.24e-11 Glomerular filtration rate (creatinine); CESC cis rs2273669 0.667 rs7759014 chr6:109351125 A/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs3106136 0.901 rs17623135 chr4:95213091 C/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.73 -0.38 1.02e-10 Capecitabine sensitivity; CESC cis rs3096299 0.874 rs3102342 chr16:89451575 T/C cg16743903 chr16:89593216 SPG7 -0.4 -5.1 -0.3 6.48e-7 Multiple myeloma (IgH translocation); CESC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg16680214 chr1:154839983 KCNN3 -0.44 -6.69 -0.38 1.28e-10 Prostate cancer; CESC cis rs74181299 0.750 rs1420185 chr2:65315903 A/G cg05010058 chr2:65284262 CEP68 0.31 5.19 0.3 4.11e-7 Pulse pressure; CESC cis rs7772486 0.686 rs9403739 chr6:146015357 A/G cg05347473 chr6:146136440 FBXO30 -0.57 -7.17 -0.4 7.53e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs4595586 0.563 rs2388178 chr12:39364366 T/G cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC cis rs12926788 0.689 rs7186308 chr16:24848471 A/G cg06028605 chr16:24865363 SLC5A11 0.47 6.7 0.38 1.26e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs936229 0.861 rs7180484 chr15:75115416 G/T cg14664628 chr15:75095509 CSK 1.03 16.93 0.72 4.22e-44 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs1023500 0.505 rs134887 chr22:42674239 A/G cg15557168 chr22:42548783 NA -0.4 -6.09 -0.35 3.97e-9 Schizophrenia; CESC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.22 0.36 1.9e-9 Menopause (age at onset); CESC cis rs796364 0.760 rs55906940 chr2:201049386 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -6.04 -0.35 5.34e-9 Schizophrenia; CESC cis rs1707322 1.000 rs4390216 chr1:46266456 C/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12973672 1.000 rs10410675 chr19:35768828 T/C cg12095397 chr19:35769544 USF2 0.54 7.35 0.41 2.49e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9916302 0.706 rs8075737 chr17:37727316 C/T cg07936489 chr17:37558343 FBXL20 0.94 11.48 0.58 4.98e-25 Glomerular filtration rate (creatinine); CESC cis rs2228479 1.000 rs62052180 chr16:89963289 C/G cg14709524 chr16:89940631 TCF25 0.72 5.45 0.32 1.16e-7 Skin colour saturation; CESC cis rs2952156 1.000 rs2643194 chr17:37853048 C/T cg00129232 chr17:37814104 STARD3 -0.68 -8.53 -0.46 1.15e-15 Asthma; CESC cis rs11608355 0.508 rs12822899 chr12:109800978 A/G cg19025524 chr12:109796872 NA -0.43 -5.37 -0.31 1.76e-7 Neuroticism; CESC trans rs2965280 0.793 rs11879050 chr19:34823233 G/T cg05799317 chr6:165723796 C6orf118 0.81 6.0 0.35 6.45e-9 Colorectal cancer; CESC cis rs4561483 0.831 rs8052900 chr16:11940390 T/C cg08843971 chr16:11963173 GSPT1 0.38 5.09 0.3 6.71e-7 Testicular germ cell tumor; CESC cis rs3733585 0.588 rs6449154 chr4:9956404 C/T cg11266682 chr4:10021025 SLC2A9 -0.59 -11.16 -0.57 5.9e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs12220238 0.822 rs7919517 chr10:76111355 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.21 0.3 3.89e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg24110177 chr3:50126178 RBM5 0.53 7.42 0.41 1.6e-12 Intelligence (multi-trait analysis); CESC cis rs9905704 0.647 rs9898048 chr17:57108543 C/T cg12560992 chr17:57184187 TRIM37 0.56 6.93 0.39 3.25e-11 Testicular germ cell tumor; CESC cis rs12369635 1.000 rs11060121 chr12:129564206 C/T cg01909103 chr12:129572610 TMEM132D -0.68 -5.96 -0.34 8.2e-9 Schizophrenia (inflammation and infection response interaction); CESC cis rs8141529 0.956 rs469989 chr22:29303595 G/C cg02153584 chr22:29168773 CCDC117 -0.46 -5.45 -0.32 1.18e-7 Lymphocyte counts; CESC cis rs9584850 0.718 rs6491427 chr13:99113166 A/G cg22223119 chr13:99095684 FARP1 -0.37 -5.3 -0.31 2.44e-7 Neuroticism; CESC cis rs2066819 1.000 rs78495928 chr12:56635080 G/C cg26734620 chr12:56694298 CS 1.05 6.75 0.38 9.35e-11 Psoriasis vulgaris; CESC cis rs36051895 0.659 rs7045342 chr9:5183892 T/C cg02405213 chr9:5042618 JAK2 -0.54 -6.51 -0.37 3.81e-10 Pediatric autoimmune diseases; CESC cis rs9443189 0.570 rs6931578 chr6:76272310 C/T cg01950844 chr6:76311363 SENP6 0.88 9.38 0.5 3e-18 Prostate cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00416492 chr6:14211855 NA -0.44 -6.24 -0.36 1.72e-9 Gambling; CESC cis rs2455799 0.613 rs2654654 chr3:15789242 C/T cg09340198 chr3:15902540 ANKRD28 -0.33 -5.16 -0.3 4.94e-7 Mean platelet volume; CESC cis rs9457247 1.000 rs415890 chr6:167406633 C/G cg07741184 chr6:167504864 NA -0.3 -5.34 -0.31 2.04e-7 Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26673286 chr19:49458596 BAX 0.49 6.19 0.36 2.24e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs5756813 0.754 rs8137848 chr22:38185994 T/G cg19894588 chr14:64061835 NA -0.64 -8.24 -0.45 7.83e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs9905704 0.633 rs2680694 chr17:56469869 T/C cg12560992 chr17:57184187 TRIM37 -0.61 -5.75 -0.33 2.49e-8 Testicular germ cell tumor; CESC cis rs68170813 0.559 rs77671232 chr7:106939202 A/G cg02696742 chr7:106810147 HBP1 -0.54 -5.26 -0.31 2.98e-7 Coronary artery disease; CESC cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg20503657 chr10:835505 NA 0.73 6.43 0.37 5.79e-10 Eosinophil percentage of granulocytes; CESC cis rs7264396 0.563 rs2425079 chr20:34298191 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.64 -0.55 3.06e-22 Total cholesterol levels; CESC cis rs763121 0.853 rs7289855 chr22:39042221 G/T cg06022373 chr22:39101656 GTPBP1 0.88 13.45 0.64 8.75e-32 Menopause (age at onset); CESC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Depression; CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg09033563 chr22:24373618 LOC391322 -0.43 -5.59 -0.32 5.66e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg26335602 chr6:28129616 ZNF389 0.46 6.09 0.35 3.87e-9 Parkinson's disease; CESC cis rs3857067 0.806 rs72665627 chr4:95111824 A/G cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC cis rs2979489 0.945 rs11992441 chr8:30313649 A/G cg26383811 chr8:30366931 RBPMS 0.82 10.01 0.52 3.21e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs9905704 0.846 rs304268 chr17:56799907 T/C cg12560992 chr17:57184187 TRIM37 0.62 7.78 0.43 1.6e-13 Testicular germ cell tumor; CESC cis rs116095464 0.558 rs6555058 chr5:226376 C/T cg22857025 chr5:266934 NA 1.25 17.78 0.74 4.46e-47 Breast cancer; CESC trans rs10242455 0.702 rs73711294 chr7:99088714 G/A cg09045935 chr12:6379348 NA 0.88 6.81 0.39 6.62e-11 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15265785 chr3:156877897 CCNL1 0.56 6.76 0.38 8.52e-11 Gut microbiome composition (summer); CESC cis rs9902453 0.817 rs1842026 chr17:28188111 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.21 0.45 9.9e-15 Coffee consumption (cups per day); CESC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg11764359 chr7:65958608 NA -0.77 -10.96 -0.56 2.63e-23 Aortic root size; CESC cis rs6696846 0.777 rs6664397 chr1:205051871 C/T cg00857998 chr1:205179979 DSTYK 0.5 6.72 0.38 1.1e-10 Red blood cell count; CESC cis rs7927592 0.701 rs12226585 chr11:68257861 A/T cg20283391 chr11:68216788 NA 0.47 6.08 0.35 4.18e-9 Total body bone mineral density; CESC cis rs7236492 0.532 rs8090536 chr18:77195553 C/T cg15644404 chr18:77186268 NFATC1 -0.49 -5.57 -0.32 6.16e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs9399135 0.967 rs6569990 chr6:135365818 C/T cg22676075 chr6:135203613 NA 0.5 7.06 0.4 1.49e-11 Red blood cell count; CESC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.47 6.05 0.35 5.05e-9 Tonsillectomy; CESC cis rs12477438 0.520 rs1453563 chr2:99720267 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 12.74 0.62 2.5e-29 Chronic sinus infection; CESC cis rs798766 1.000 rs3752749 chr4:1737262 T/C cg05874882 chr4:1763078 NA -0.56 -7.28 -0.41 3.86e-12 Bladder cancer;Urinary bladder cancer; CESC cis rs6120849 1.000 rs6120849 chr20:33730387 C/T cg24642439 chr20:33292090 TP53INP2 0.66 7.05 0.4 1.57e-11 Protein C levels; CESC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.64 6.68 0.38 1.44e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11702503 chr19:6215254 MLLT1 -0.65 -7.34 -0.41 2.6e-12 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs10076655 chr5:239464 G/C cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.32 0.31 2.18e-7 Breast cancer; CESC trans rs1814175 0.817 rs80244685 chr11:49763292 C/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.05 -0.35 4.99e-9 Height; CESC cis rs12360000 0.797 rs12768776 chr10:1901587 C/T cg26364871 chr10:1889757 NA -0.39 -5.16 -0.3 4.81e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs2857078 0.772 rs4793086 chr17:42320751 C/T cg13607699 chr17:42295918 UBTF -0.77 -10.62 -0.55 3.61e-22 Red cell distribution width;Reticulocyte count; CESC cis rs6963495 0.818 rs73192143 chr7:105202415 A/G cg19920283 chr7:105172520 RINT1 0.68 6.27 0.36 1.47e-9 Bipolar disorder (body mass index interaction); CESC cis rs4076764 0.914 rs4638099 chr1:163365521 A/G cg24596788 chr1:163392923 NA 0.52 7.65 0.43 3.66e-13 Motion sickness; CESC cis rs4704187 0.640 rs1600075 chr5:74418304 G/A cg03227963 chr5:74354835 NA 0.31 5.7 0.33 3.22e-8 Response to amphetamines; CESC cis rs10465746 0.704 rs6667468 chr1:84479507 G/A cg10977910 chr1:84465055 TTLL7 0.41 5.09 0.3 6.72e-7 Obesity-related traits; CESC cis rs9682041 0.569 rs11914970 chr3:170112307 T/G cg11886554 chr3:170076028 SKIL 0.57 5.72 0.33 2.82e-8 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg11663144 chr21:46675770 NA -0.61 -9.5 -0.5 1.27e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00419759 chr1:114301964 PHTF1 0.5 6.47 0.37 4.71e-10 Systemic lupus erythematosus; CESC cis rs7208859 0.623 rs11652631 chr17:29060766 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs1814175 0.585 rs4881661 chr11:50000117 A/G cg03929089 chr4:120376271 NA -0.91 -14.65 -0.67 5.08e-36 Height; CESC cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg10578991 chr7:12443926 VWDE -0.49 -5.53 -0.32 7.51e-8 Coronary artery disease; CESC trans rs11722228 0.522 rs73212817 chr4:10064011 T/C cg26043149 chr18:55253948 FECH 0.88 10.22 0.53 6.8e-21 Gout;Urate levels;Serum uric acid levels; CESC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg19163074 chr7:65112434 INTS4L2 0.46 5.05 0.3 8.07e-7 Aortic root size; CESC cis rs3733585 0.699 rs6449176 chr4:9967843 G/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.58 -0.32 5.96e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7680126 0.585 rs34768406 chr4:10118350 C/A cg00071950 chr4:10020882 SLC2A9 -0.58 -6.05 -0.35 4.9e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs3096299 0.781 rs2965819 chr16:89501030 G/T cg08822215 chr16:89438651 ANKRD11 0.35 5.3 0.31 2.49e-7 Multiple myeloma (IgH translocation); CESC cis rs17433780 0.808 rs7541867 chr1:89513537 G/A cg09516651 chr1:89888402 LOC400759 0.7 10.7 0.55 1.94e-22 Carotid intima media thickness; CESC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs2425143 1.000 rs4504072 chr20:34448773 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.62 0.33 4.72e-8 Blood protein levels; CESC cis rs921968 0.643 rs711186 chr2:219346102 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.81 -0.39 6.53e-11 Mean corpuscular hemoglobin concentration; CESC cis rs2228479 0.850 rs62052660 chr16:89847420 T/A cg06558623 chr16:89946397 TCF25 1.17 9.37 0.5 3.31e-18 Skin colour saturation; CESC cis rs6500395 0.925 rs6500396 chr16:48625458 A/T cg04672837 chr16:48644449 N4BP1 0.51 6.5 0.37 3.95e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs116095464 0.510 rs55750776 chr5:230467 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.69 0.33 3.34e-8 Breast cancer; CESC cis rs9858542 1.000 rs9812791 chr3:49682311 G/A cg07274523 chr3:49395745 GPX1 0.67 8.56 0.47 9.19e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2730245 0.527 rs2036582 chr7:158701708 A/T cg24397884 chr7:158709396 WDR60 0.68 7.16 0.4 8.17e-12 Height; CESC cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.26 0.31 2.9e-7 Personality dimensions; CESC cis rs4450131 0.522 rs2272005 chr10:126402100 C/T cg20435097 chr10:126320824 FAM53B 0.28 5.08 0.3 7.28e-7 White blood cell count (basophil); CESC cis rs35955747 0.738 rs2012451 chr22:31844373 A/C cg25791279 chr22:32026902 PISD -0.43 -5.33 -0.31 2.11e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs9430161 0.579 rs10864486 chr1:11040979 A/G cg27631724 chr1:11040367 C1orf127 0.44 7.61 0.42 4.72e-13 Ewing sarcoma; CESC cis rs2735413 0.881 rs4888727 chr16:78077038 T/C cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs72781680 0.752 rs7578606 chr2:23902360 T/C cg08917208 chr2:24149416 ATAD2B 1.17 10.72 0.55 1.61e-22 Lymphocyte counts; CESC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs5758659 0.652 rs133303 chr22:42395242 C/G cg04733989 chr22:42467013 NAGA 0.42 5.59 0.32 5.71e-8 Cognitive function; CESC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg16325326 chr1:53192061 ZYG11B -0.72 -11.9 -0.59 1.88e-26 Monocyte count; CESC cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11190604 1.000 rs2495754 chr10:102324812 C/T cg07080220 chr10:102295463 HIF1AN 0.63 5.98 0.34 7.11e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs7539409 0.651 rs969724 chr1:84300712 T/G cg10977910 chr1:84465055 TTLL7 0.8 7.62 0.42 4.64e-13 Alzheimer's disease; CESC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg11644478 chr21:40555479 PSMG1 -0.54 -7.14 -0.4 9.04e-12 Menarche (age at onset); CESC cis rs4642101 0.765 rs3901665 chr3:12824610 C/A cg05775895 chr3:12838266 CAND2 0.39 6.0 0.35 6.55e-9 QRS complex (12-leadsum); CESC cis rs763121 0.962 rs1980455 chr22:38925719 A/C cg06544989 chr22:39130855 UNC84B 0.44 7.91 0.44 7.2e-14 Menopause (age at onset); CESC cis rs3858526 0.883 rs10769326 chr11:5934358 C/T cg13902645 chr11:5959945 NA -0.55 -6.56 -0.37 2.87e-10 DNA methylation (variation); CESC trans rs9929218 1.000 rs4500718 chr16:68754312 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.72 -9.46 -0.5 1.72e-18 Colorectal cancer; CESC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.69 0.38 1.3100000000000001e-10 Prudent dietary pattern; CESC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg20933634 chr6:27740509 NA -0.52 -5.95 -0.34 8.45e-9 Depression; CESC cis rs1546924 0.692 rs197374 chr1:112289983 C/T cg23955903 chr1:112298873 DDX20;C1orf183 0.42 5.52 0.32 8.09e-8 Body mass index; CESC cis rs17376456 0.825 rs13357713 chr5:93145423 T/C cg25358565 chr5:93447407 FAM172A 1.11 10.65 0.55 2.72e-22 Diabetic retinopathy; CESC cis rs4664304 0.802 rs17830307 chr2:160871799 T/C cg03641300 chr2:160917029 PLA2R1 -0.53 -7.47 -0.42 1.2e-12 Crohn's disease;Inflammatory bowel disease; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg06429195 chr3:16646582 DAZL 0.47 6.28 0.36 1.39e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.48 -5.86 -0.34 1.34e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2742417 0.935 rs2673028 chr3:45759654 A/G cg10512202 chr3:45649293 LIMD1 0.35 5.04 0.3 8.62e-7 Response to anti-depressant treatment in major depressive disorder; CESC cis rs7692995 0.844 rs16895971 chr4:17884986 A/G cg08925142 chr4:18023851 LCORL -0.46 -5.07 -0.3 7.32e-7 Height; CESC cis rs7178572 0.633 rs4886877 chr15:77838535 C/G cg22256960 chr15:77711686 NA -0.59 -7.65 -0.43 3.74e-13 Type 2 diabetes; CESC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg03647317 chr4:187891568 NA -0.44 -6.42 -0.37 6.16e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs932287 0.666 rs10840161 chr11:9053824 G/A cg12365402 chr11:9010492 NRIP3 0.37 6.16 0.35 2.71e-9 Colonoscopy-negative controls vs population controls; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg13355623 chr17:26898935 PIGS -0.43 -6.36 -0.36 8.61e-10 Vertical cup-disc ratio; CESC cis rs6500395 0.962 rs9921737 chr16:48589873 G/T cg04672837 chr16:48644449 N4BP1 0.46 5.61 0.33 5.16e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg10074409 chr1:209979377 IRF6 0.38 5.99 0.35 6.7e-9 Cleft lip with or without cleft palate; CESC trans rs61931739 0.500 rs9919726 chr12:34510783 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.55 0.42 7.05e-13 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06917548 chr19:16643283 CHERP -0.57 -6.57 -0.37 2.65e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11664809 chr8:146126282 ZNF250 -0.6 -7.1 -0.4 1.13e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.785 rs11944120 chr4:99079932 A/C cg05340658 chr4:99064831 C4orf37 0.61 7.11 0.4 1.1e-11 Colonoscopy-negative controls vs population controls; CESC cis rs4680748 0.661 rs6800659 chr3:28270669 A/G cg15038811 chr3:28283857 CMC1 -0.36 -5.41 -0.32 1.41e-7 Colonoscopy-negative controls vs population controls; CESC trans rs1728785 0.901 rs12929568 chr16:68596689 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 7.08 0.4 1.3e-11 Ulcerative colitis; CESC cis rs6736093 0.966 rs13003919 chr2:112753950 A/G cg12686935 chr2:112915763 FBLN7 0.42 5.44 0.32 1.22e-7 Coronary artery disease; CESC cis rs7605827 0.930 rs2010881 chr2:15624646 T/A cg19274914 chr2:15703543 NA 0.36 6.49 0.37 4.08e-10 Educational attainment (years of education); CESC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.41 6.86 0.39 4.74e-11 Personality dimensions; CESC cis rs8005677 1.000 rs8016061 chr14:23375809 A/G cg01529538 chr14:23388837 RBM23 0.51 6.99 0.39 2.25e-11 Cognitive ability (multi-trait analysis); CESC cis rs1878931 0.513 rs35160989 chr16:3405506 G/A cg22508957 chr16:3507546 NAT15 -0.36 -5.22 -0.31 3.66e-7 Body mass index (adult); CESC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.76 0.33 2.3e-8 Menopause (age at onset); CESC cis rs763121 0.853 rs5757162 chr22:38993370 C/T cg06544989 chr22:39130855 UNC84B 0.5 8.26 0.45 6.86e-15 Menopause (age at onset); CESC cis rs4664308 1.000 rs6759836 chr2:160912802 C/T cg03641300 chr2:160917029 PLA2R1 -0.67 -10.16 -0.53 1.11e-20 Idiopathic membranous nephropathy; CESC trans rs1945213 0.694 rs12222077 chr11:55848116 T/A cg03929089 chr4:120376271 NA 0.76 7.26 0.41 4.31e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs7264396 0.635 rs6060696 chr20:34522060 C/T cg17201900 chr20:34330562 RBM39 0.49 5.13 0.3 5.62e-7 Total cholesterol levels; CESC cis rs873946 0.564 rs2803992 chr10:134550882 T/C cg18305652 chr10:134549665 INPP5A 0.49 7.55 0.42 6.96e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs6547741 1.000 rs13026621 chr2:27807624 G/A cg21248554 chr2:27665150 KRTCAP3 0.25 5.08 0.3 7.23e-7 Oral cavity cancer; CESC trans rs4129059 0.765 rs57047137 chr1:214708900 C/T cg08821431 chr12:34491090 NA 0.63 6.97 0.39 2.54e-11 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg23422044 chr7:1970798 MAD1L1 -0.48 -5.21 -0.31 3.73e-7 Bipolar disorder; CESC cis rs6582630 0.519 rs8189549 chr12:38245752 A/G cg26384229 chr12:38710491 ALG10B 0.71 10.11 0.53 1.52e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs9549367 0.789 rs9577220 chr13:113908294 T/A cg00898013 chr13:113819073 PROZ -0.52 -7.45 -0.42 1.31e-12 Platelet distribution width; CESC cis rs6032067 0.777 rs13037651 chr20:43782230 C/G cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs7395581 0.959 rs59663860 chr11:47276350 G/C cg25783544 chr11:47291846 MADD 0.6 7.8 0.43 1.47e-13 HDL cholesterol; CESC cis rs67311347 1.000 rs13095055 chr3:40505666 G/T cg24209194 chr3:40518798 ZNF619 -0.58 -7.88 -0.44 8.41e-14 Renal cell carcinoma; CESC cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg26597838 chr10:835615 NA 0.83 9.08 0.49 2.65e-17 Eosinophil percentage of granulocytes; CESC cis rs938554 0.692 rs6449213 chr4:9994215 A/G cg11266682 chr4:10021025 SLC2A9 -0.48 -6.15 -0.35 2.83e-9 Blood metabolite levels; CESC cis rs1568889 0.838 rs7943538 chr11:28288955 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 12.47 0.61 2.16e-28 Bipolar disorder; CESC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg06456125 chr7:65229604 NA -0.48 -6.34 -0.36 9.96e-10 Aortic root size; CESC cis rs6665290 0.935 rs1929863 chr1:227195728 C/T cg10327440 chr1:227177885 CDC42BPA -1.23 -34.09 -0.9 6.84e-99 Myeloid white cell count; CESC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.51 0.37 3.85e-10 Bipolar disorder; CESC cis rs7727544 0.684 rs272874 chr5:131675046 A/G cg24060327 chr5:131705240 SLC22A5 0.53 5.44 0.32 1.21e-7 Blood metabolite levels; CESC cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg11764359 chr7:65958608 NA 0.66 8.2 0.45 1.03e-14 Aortic root size; CESC cis rs748404 0.660 rs689767 chr15:43722077 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.13 0.45 1.61e-14 Lung cancer; CESC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg11890956 chr21:40555474 PSMG1 -0.65 -8.96 -0.48 5.97e-17 Menarche (age at onset); CESC cis rs11264213 0.681 rs79419570 chr1:36210279 G/A cg27506609 chr1:36549197 TEKT2 0.64 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs643506 0.874 rs10789849 chr11:111716070 A/C cg17089665 chr11:111648010 NA -0.38 -5.58 -0.32 5.97e-8 Breast cancer; CESC cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg00409905 chr10:38381863 ZNF37A -0.47 -6.22 -0.36 1.91e-9 Extrinsic epigenetic age acceleration; CESC cis rs2066819 1.000 rs2066808 chr12:56737973 A/G cg26714650 chr12:56694279 CS -1.22 -14.6 -0.67 8.06e-36 Psoriasis vulgaris; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25680105 chr8:82434497 NA 0.5 6.37 0.36 8.32e-10 Fibrinogen levels; CESC cis rs35275482 0.607 rs2965331 chr15:60113632 A/G cg11160654 chr15:60369068 NA 0.34 5.05 0.3 8.14e-7 Gut microbiota (bacterial taxa); CESC cis rs748404 0.697 rs491804 chr15:43560825 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.71 0.43 2.46e-13 Lung cancer; CESC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg22535103 chr8:58192502 C8orf71 -0.77 -8.78 -0.47 2.12e-16 Developmental language disorder (linguistic errors); CESC cis rs3740713 1.000 rs73438690 chr11:18461214 A/C cg23797887 chr11:18477753 LDHAL6A -0.54 -5.28 -0.31 2.63e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs12541635 0.934 rs10955407 chr8:107020648 G/A cg10147462 chr8:107024639 NA 0.41 5.94 0.34 8.76e-9 Age of smoking initiation; CESC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg18252515 chr7:66147081 NA -0.47 -6.14 -0.35 3.09e-9 Aortic root size; CESC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg15145296 chr3:125709740 NA -0.49 -5.42 -0.32 1.31e-7 Blood pressure (smoking interaction); CESC cis rs17253792 0.822 rs17683656 chr14:56053361 C/T cg01858014 chr14:56050164 KTN1 0.86 6.8 0.39 6.73e-11 Putamen volume; CESC cis rs11958404 0.932 rs72816571 chr5:157429759 C/T cg05962755 chr5:157440814 NA 0.62 6.53 0.37 3.41e-10 IgG glycosylation; CESC cis rs4919694 0.908 rs11191523 chr10:104792400 A/G cg04362960 chr10:104952993 NT5C2 0.77 6.69 0.38 1.34e-10 Arsenic metabolism; CESC cis rs2479724 0.792 rs7739064 chr6:41834037 C/A cg08135965 chr6:41755394 TOMM6 0.4 5.46 0.32 1.07e-7 Menarche (age at onset); CESC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg03033257 chr22:50311977 ALG12;CRELD2 0.52 5.25 0.31 3.11e-7 Schizophrenia; CESC cis rs6964587 1.000 rs2888851 chr7:91648341 G/A cg17063962 chr7:91808500 NA 0.58 8.02 0.44 3.36e-14 Breast cancer; CESC cis rs7605378 0.964 rs2689763 chr2:200689555 G/A cg23649088 chr2:200775458 C2orf69 0.53 6.88 0.39 4.19e-11 Osteoporosis; CESC cis rs17376456 0.825 rs55724660 chr5:93276636 A/G cg21475434 chr5:93447410 FAM172A 0.77 6.36 0.36 8.6e-10 Diabetic retinopathy; CESC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg17971929 chr21:40555470 PSMG1 -0.85 -12.37 -0.6 4.79e-28 Cognitive function; CESC cis rs6952809 0.504 rs1978169 chr7:2434522 G/A cg25507518 chr7:2405875 EIF3B 0.44 5.04 0.3 8.58e-7 Multiple sclerosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21940081 chr2:131103235 IMP4 0.49 6.42 0.37 6.18e-10 Fibrinogen levels; CESC trans rs2727020 0.554 rs7111711 chr11:49557880 G/A cg15704280 chr7:45808275 SEPT13 -0.82 -9.94 -0.52 5.55e-20 Coronary artery disease; CESC cis rs3820068 0.608 rs10927840 chr1:16045250 A/G cg13390004 chr1:15929781 NA 0.34 5.23 0.31 3.48e-7 Systolic blood pressure; CESC cis rs12597458 0.763 rs3213422 chr16:72042682 A/C cg16558253 chr16:72132732 DHX38 0.41 5.82 0.34 1.66e-8 Prostate cancer; CESC cis rs921968 0.565 rs35358516 chr2:219625723 A/C cg02176678 chr2:219576539 TTLL4 -0.45 -7.83 -0.43 1.15e-13 Mean corpuscular hemoglobin concentration; CESC cis rs854765 0.647 rs854808 chr17:18006634 C/T cg16928487 chr17:17741425 SREBF1 -0.54 -8.8 -0.48 1.78e-16 Total body bone mineral density; CESC cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg10556349 chr10:835070 NA 0.75 6.28 0.36 1.34e-9 Eosinophil percentage of granulocytes; CESC cis rs9796 0.621 rs2899013 chr15:41492283 G/T cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.61 -0.38 2.13e-10 Menopause (age at onset); CESC cis rs6695640 0.820 rs2800686 chr1:17763312 C/T cg01904812 chr1:17746340 RCC2 -0.35 -5.15 -0.3 5.12e-7 Mean platelet volume; CESC cis rs9300255 0.639 rs1716171 chr12:123716376 C/T cg19016782 chr12:123741754 C12orf65 -0.5 -7.1 -0.4 1.18e-11 Neutrophil percentage of white cells; CESC cis rs3733585 0.673 rs6449156 chr4:9956712 G/C cg11266682 chr4:10021025 SLC2A9 -0.58 -10.84 -0.55 6.77e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10771431 1.000 rs10771431 chr12:9380859 C/T cg08997352 chr12:9597637 DDX12 -0.61 -8.1 -0.45 2e-14 Breast size; CESC cis rs1395 0.744 rs1122227 chr2:27544285 C/T cg22903471 chr2:27725779 GCKR -0.51 -6.25 -0.36 1.66e-9 Blood metabolite levels; CESC trans rs11722228 0.522 rs2241468 chr4:10113905 G/A cg26043149 chr18:55253948 FECH 0.99 11.73 0.58 7.34e-26 Gout;Urate levels;Serum uric acid levels; CESC cis rs72615157 0.539 rs2261360 chr7:99692993 G/T cg22004693 chr7:99632812 ZKSCAN1 0.43 5.41 0.32 1.44e-7 Lung function (FEV1/FVC); CESC cis rs12410462 0.681 rs12401677 chr1:227608577 T/C cg23173402 chr1:227635558 NA 0.74 6.78 0.38 7.82e-11 Major depressive disorder; CESC cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.39 0.31 1.59e-7 Personality dimensions; CESC cis rs10489202 1.000 rs7538581 chr1:167979347 A/G cg24449463 chr1:168025552 DCAF6 -0.45 -5.18 -0.3 4.45e-7 Schizophrenia; CESC cis rs7772486 0.790 rs2249147 chr6:146184999 T/C cg05347473 chr6:146136440 FBXO30 0.55 7.21 0.4 5.88e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg13126279 chr21:47581558 C21orf56 -0.51 -6.91 -0.39 3.64e-11 Testicular germ cell tumor; CESC cis rs7914558 0.966 rs3977751 chr10:104920232 A/G cg04362960 chr10:104952993 NT5C2 0.45 5.88 0.34 1.21e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs11190604 1.000 rs12355721 chr10:102244911 C/T cg07080220 chr10:102295463 HIF1AN 0.55 5.44 0.32 1.21e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs12479064 0.724 rs737094 chr2:100089078 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.53 -6.07 -0.35 4.53e-9 Chronic sinus infection; CESC cis rs9388451 0.805 rs1028481 chr6:126106573 G/T cg05901451 chr6:126070800 HEY2 -0.63 -9.17 -0.49 1.35e-17 Brugada syndrome; CESC cis rs698813 0.604 rs1596009 chr2:44492102 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.6 0.33 5.26e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs8002861 0.905 rs12430629 chr13:44415919 T/A cg19180546 chr13:44453867 C13orf31;CCDC122 -0.41 -5.2 -0.3 4.01e-7 Leprosy; CESC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg25319279 chr11:5960081 NA -0.35 -5.47 -0.32 1.02e-7 DNA methylation (variation); CESC cis rs9640161 0.830 rs17173682 chr7:150059602 A/G cg10018233 chr7:150070692 REPIN1 0.36 5.63 0.33 4.57e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs2228479 0.850 rs62056102 chr16:89941438 T/C cg00800038 chr16:89945340 TCF25 -0.94 -7.79 -0.43 1.52e-13 Skin colour saturation; CESC trans rs12599106 0.715 rs34006830 chr16:34878550 C/A cg01516881 chr6:292596 DUSP22 -0.84 -10.82 -0.55 7.53e-23 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24343413 chr1:151735844 OAZ3;MRPL9 -0.37 -6.17 -0.35 2.57e-9 Gambling; CESC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg27165867 chr14:105738592 BRF1 -0.51 -5.4 -0.31 1.46e-7 Mean platelet volume;Platelet distribution width; CESC cis rs916888 0.738 rs199515 chr17:44856641 C/G cg17911788 chr17:44343683 NA 0.54 7.56 0.42 6.81e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7264396 0.635 rs6121102 chr20:34544274 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.57 6.97 0.39 2.48e-11 Total cholesterol levels; CESC cis rs7385804 0.761 rs504141 chr7:100309125 G/A cg16850897 chr7:100343110 ZAN 0.47 6.41 0.37 6.69e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs4948102 0.686 rs11771788 chr7:56158040 T/C cg09872392 chr7:56161020 PHKG1 -0.47 -7.49 -0.42 1.05e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs5769765 0.908 rs9616216 chr22:50318927 T/C cg02269571 chr22:50332266 NA -0.55 -6.42 -0.37 6.1e-10 Schizophrenia; CESC cis rs7474896 0.515 rs2749582 chr10:38275284 A/G cg25427524 chr10:38739819 LOC399744 0.49 5.63 0.33 4.63e-8 Obesity (extreme); CESC cis rs11098499 0.754 rs12510269 chr4:120241646 A/G cg09307838 chr4:120376055 NA 0.79 10.62 0.55 3.55e-22 Corneal astigmatism; CESC trans rs3780486 0.505 rs959749 chr9:33147858 T/C cg20290983 chr6:43655470 MRPS18A 0.73 11.46 0.58 5.66e-25 IgG glycosylation; CESC cis rs4315565 0.688 rs4608564 chr2:69266804 C/T cg12800200 chr2:69260302 ANTXR1 -0.4 -5.58 -0.32 5.88e-8 Height; CESC cis rs739401 0.611 rs401707 chr11:3050965 T/C cg25174290 chr11:3078921 CARS 0.55 7.58 0.42 5.71e-13 Longevity; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg07292445 chr17:27055725 NEK8 -0.44 -6.12 -0.35 3.28e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7223966 1.000 rs7223672 chr17:61720565 T/C cg11494091 chr17:61959527 GH2 0.38 5.06 0.3 7.81e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs8099014 0.906 rs4940696 chr18:56106596 C/T cg19312305 chr18:56117016 MIR122 0.26 5.15 0.3 5.02e-7 Platelet count; CESC cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg24110177 chr3:50126178 RBM5 -0.52 -7.06 -0.4 1.42e-11 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03981592 chr3:86061698 CADM2 -0.58 -6.83 -0.39 5.78e-11 Gut microbiome composition (summer); CESC cis rs9788682 0.747 rs2568497 chr15:78721397 G/T cg24631222 chr15:78858424 CHRNA5 -0.61 -7.04 -0.4 1.67e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg07090678 chr1:91966139 CDC7 -0.44 -5.84 -0.34 1.49e-8 Breast cancer; CESC cis rs4595586 0.655 rs11831502 chr12:39310127 A/T cg26384229 chr12:38710491 ALG10B 0.42 6.11 0.35 3.51e-9 Morning vs. evening chronotype; CESC cis rs34638657 0.656 rs2911429 chr16:82203443 T/C cg09439754 chr16:82129088 HSD17B2 -0.36 -5.93 -0.34 9.32e-9 Lung adenocarcinoma; CESC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg19346786 chr7:2764209 NA -0.48 -7.08 -0.4 1.31e-11 Height; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19309549 chr1:100435460 SLC35A3 0.48 6.16 0.35 2.65e-9 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13598790 chr5:55007947 SLC38A9 0.61 7.13 0.4 9.62e-12 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg25072359 chr17:41440525 NA 0.44 6.04 0.35 5.21e-9 Menopause (age at onset); CESC cis rs9926296 0.632 rs9935559 chr16:89800529 C/T cg04287289 chr16:89883240 FANCA -0.64 -8.44 -0.46 2.15e-15 Vitiligo; CESC cis rs1355223 0.507 rs11032903 chr11:34876176 C/T cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.59 -0.38 2.37e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7192380 0.630 rs2965749 chr16:69771914 C/T cg15192750 chr16:69999425 NA -0.37 -5.11 -0.3 6.03e-7 Sjögren's syndrome; CESC cis rs1707322 0.682 rs10890335 chr1:46100394 G/C cg06784218 chr1:46089804 CCDC17 0.4 6.99 0.39 2.23e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs911555 0.511 rs8007489 chr14:104054572 A/G cg12935359 chr14:103987150 CKB 0.43 6.48 0.37 4.35e-10 Intelligence (multi-trait analysis); CESC cis rs7927592 0.913 rs7104345 chr11:68316772 G/A cg20283391 chr11:68216788 NA -0.61 -7.36 -0.41 2.26e-12 Total body bone mineral density; CESC cis rs11690935 0.879 rs908671 chr2:172690265 C/G cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.1 -0.65 4.75e-34 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15951691 chr7:150065937 REPIN1 0.48 5.99 0.35 6.66e-9 Gut microbiota (bacterial taxa); CESC cis rs9611519 0.507 rs12484525 chr22:41443877 G/C cg03806693 chr22:41940476 POLR3H -0.5 -5.99 -0.35 6.73e-9 Neuroticism; CESC cis rs748404 0.660 rs690446 chr15:43761264 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.21 0.45 9.59e-15 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06807593 chr18:51795886 POLI 0.59 6.25 0.36 1.65e-9 Gut microbiome composition (summer); CESC cis rs3741151 0.686 rs73546735 chr11:73256797 C/T cg17517138 chr11:73019481 ARHGEF17 1.05 7.72 0.43 2.46e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23932593 chr6:133135524 RPS12;SNORD101 0.52 6.19 0.36 2.24e-9 Gut microbiome composition (summer); CESC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg25036284 chr2:26402008 FAM59B -0.83 -9.85 -0.52 1.01e-19 Gut microbiome composition (summer); CESC cis rs2933343 0.621 rs789249 chr3:128578453 T/C cg24203234 chr3:128598194 ACAD9 0.41 5.66 0.33 4e-8 IgG glycosylation; CESC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg08968635 chr6:28129556 ZNF389 0.41 5.51 0.32 8.4e-8 Parkinson's disease; CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg18538332 chr22:24372958 LOC391322 -0.78 -11.72 -0.58 7.97e-26 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10979 1.000 rs12212011 chr6:143894694 C/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs2797160 1.000 rs1739377 chr6:126012236 T/C cg05901451 chr6:126070800 HEY2 0.46 6.63 0.38 1.87e-10 Endometrial cancer; CESC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC cis rs7084402 0.967 rs1649059 chr10:60312599 T/C cg07615347 chr10:60278583 BICC1 0.61 9.6 0.51 6.58e-19 Refractive error; CESC cis rs11630290 0.736 rs2197259 chr15:64154156 T/C cg12036633 chr15:63758958 NA 0.52 5.64 0.33 4.32e-8 Iris characteristics; CESC cis rs9868809 0.772 rs9809222 chr3:48714411 C/T cg03060546 chr3:49711283 APEH -0.67 -5.73 -0.33 2.68e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs6831352 0.703 rs2602862 chr4:100033221 A/G cg13256891 chr4:100009986 ADH5 0.69 8.13 0.45 1.61e-14 Alcohol dependence; CESC cis rs4950322 0.857 rs55790545 chr1:146838364 C/A cg22381352 chr1:146742008 CHD1L -0.45 -5.19 -0.3 4.12e-7 Protein quantitative trait loci; CESC cis rs13108904 0.775 rs2279282 chr4:1216033 G/C cg16405210 chr4:1374714 KIAA1530 -0.45 -5.48 -0.32 1.01e-7 Obesity-related traits; CESC cis rs9905704 0.881 rs12942879 chr17:56861253 G/A cg12560992 chr17:57184187 TRIM37 0.61 7.15 0.4 8.7e-12 Testicular germ cell tumor; CESC cis rs9640161 0.789 rs28439010 chr7:150046276 C/T cg17279839 chr7:150038598 RARRES2 0.49 5.92 0.34 9.88e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg01475377 chr6:109611718 NA -0.51 -8.56 -0.47 9.09e-16 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24000912 chr8:8082819 NA -0.49 -6.57 -0.37 2.73e-10 Gut microbiome composition (summer); CESC cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg13902645 chr11:5959945 NA -0.61 -7.19 -0.4 6.77e-12 DNA methylation (variation); CESC cis rs2243480 1.000 rs410128 chr7:65603173 C/T cg18252515 chr7:66147081 NA -1.4 -13.69 -0.64 1.22e-32 Diabetic kidney disease; CESC cis rs796364 0.806 rs35200468 chr2:201110368 G/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.31 -0.36 1.14e-9 Schizophrenia; CESC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.36 0.5 3.44e-18 Menopause (age at onset); CESC cis rs1153858 1.000 rs66528868 chr15:45668547 A/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9814567 1.000 rs9876658 chr3:134179453 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.35 5.03 0.3 9.23e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9291683 0.546 rs13146686 chr4:10034933 A/G cg00071950 chr4:10020882 SLC2A9 0.77 12.79 0.62 1.73e-29 Bone mineral density; CESC cis rs977987 0.778 rs12929908 chr16:75462071 C/T cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg17143192 chr8:8559678 CLDN23 0.71 8.18 0.45 1.16e-14 Obesity-related traits; CESC cis rs7103648 0.897 rs2278890 chr11:47399602 G/A cg20307385 chr11:47447363 PSMC3 0.95 14.26 0.66 1.26e-34 Diastolic blood pressure;Systolic blood pressure; CESC cis rs9303280 0.776 rs9891174 chr17:38031802 T/A cg19468946 chr17:37922297 IKZF3 -0.4 -5.31 -0.31 2.28e-7 Self-reported allergy; CESC cis rs11657217 0.638 rs4313839 chr17:77698619 C/T cg06901238 chr17:77706717 ENPP7 -0.44 -6.43 -0.37 6.08e-10 Diastolic blood pressure response to hydrochlorothiazide in hypertension; CESC cis rs6964587 0.626 rs6951795 chr7:91543764 T/C cg17063962 chr7:91808500 NA -0.46 -6.64 -0.38 1.8e-10 Breast cancer; CESC cis rs7605827 0.930 rs12991640 chr2:15505789 T/C cg19274914 chr2:15703543 NA 0.32 5.76 0.33 2.33e-8 Educational attainment (years of education); CESC cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg17366294 chr4:99064904 C4orf37 0.57 7.96 0.44 4.98e-14 Colonoscopy-negative controls vs population controls; CESC cis rs4704187 0.687 rs10051422 chr5:74502573 G/A cg03227963 chr5:74354835 NA 0.28 5.18 0.3 4.33e-7 Response to amphetamines; CESC cis rs9916302 0.861 rs7503514 chr17:37669884 G/C cg07936489 chr17:37558343 FBXL20 -0.8 -11.82 -0.59 3.49e-26 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08242217 chr21:40752130 WRB 0.55 6.29 0.36 1.34e-9 Gut microbiome composition (summer); CESC cis rs916888 0.821 rs199507 chr17:44858855 A/G cg14517863 chr17:44321492 NA -0.4 -5.16 -0.3 4.82e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs17666538 0.585 rs4448252 chr8:615597 A/G cg02524346 chr8:600233 NA 0.83 6.05 0.35 4.92e-9 IgG glycosylation; CESC cis rs2404602 0.735 rs11637490 chr15:76759565 A/G cg23625390 chr15:77176239 SCAPER -0.42 -5.81 -0.34 1.83e-8 Blood metabolite levels; CESC cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg20476274 chr7:133979776 SLC35B4 0.69 10.36 0.54 2.5e-21 Mean platelet volume; CESC cis rs477692 0.637 rs10829598 chr10:131319774 C/G cg24747557 chr10:131355152 MGMT -0.37 -5.09 -0.3 6.87e-7 Response to temozolomide; CESC cis rs8133932 0.654 rs402039 chr21:47358809 A/G cg14185626 chr21:47401492 COL6A1 -0.46 -5.19 -0.3 4.22e-7 Schizophrenia; CESC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.23 0.31 3.48e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg27094323 chr7:1216898 NA -0.38 -5.18 -0.3 4.49e-7 Longevity;Endometriosis; CESC cis rs2832191 0.597 rs8127842 chr21:30516461 G/A cg08807101 chr21:30365312 RNF160 -0.56 -6.41 -0.37 6.63e-10 Dental caries; CESC cis rs11098499 0.863 rs1480936 chr4:120462861 C/T cg24375607 chr4:120327624 NA 0.44 5.31 0.31 2.31e-7 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10018778 chr12:58138402 TSPAN31 -0.61 -6.93 -0.39 3.16e-11 Gut microbiome composition (summer); CESC cis rs6088765 0.606 rs2425024 chr20:33844938 G/T cg08999081 chr20:33150536 PIGU -0.4 -5.86 -0.34 1.34e-8 Ulcerative colitis; CESC cis rs11864453 0.826 rs8062041 chr16:72088964 C/T cg01557791 chr16:72042693 DHODH -0.61 -7.91 -0.44 6.83e-14 Fibrinogen levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05380570 chr1:17866686 ARHGEF10L -0.43 -6.07 -0.35 4.38e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02237855 chr2:74329332 TET3 -0.74 -8.51 -0.46 1.28e-15 Gut microbiome composition (summer); CESC cis rs2933343 0.649 rs789219 chr3:128592520 G/A cg24203234 chr3:128598194 ACAD9 0.43 5.91 0.34 1.04e-8 IgG glycosylation; CESC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg12034118 chr1:209979487 IRF6 -0.46 -5.61 -0.33 5.13e-8 Cleft lip with or without cleft palate; CESC cis rs7799006 0.606 rs7792045 chr7:2316852 C/T cg08027265 chr7:2291960 NA -0.57 -9.39 -0.5 2.97e-18 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9788682 1.000 rs61204066 chr15:78815298 G/A cg24631222 chr15:78858424 CHRNA5 0.76 9.69 0.51 3.35e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs116095464 0.558 rs7356561 chr5:284381 G/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.41 0.32 1.38e-7 Breast cancer; CESC cis rs769267 0.629 rs7245672 chr19:19699963 T/C cg03709012 chr19:19516395 GATAD2A -0.65 -7.87 -0.44 8.95e-14 Tonsillectomy; CESC cis rs4722166 0.597 rs1554606 chr7:22768707 T/G cg05265849 chr7:22767390 IL6 0.41 5.69 0.33 3.32e-8 Lung cancer; CESC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg04944784 chr2:26401820 FAM59B -0.95 -10.38 -0.54 2.13e-21 Gut microbiome composition (summer); CESC cis rs763121 0.889 rs1837988 chr22:38901094 A/G cg06544989 chr22:39130855 UNC84B 0.45 7.36 0.41 2.26e-12 Menopause (age at onset); CESC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg18904891 chr8:8559673 CLDN23 0.68 7.73 0.43 2.27e-13 Obesity-related traits; CESC cis rs67311347 0.713 rs9861194 chr3:40309225 C/T cg09455208 chr3:40491958 NA 0.44 7.36 0.41 2.38e-12 Renal cell carcinoma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25946722 chr6:105307729 HACE1 -0.42 -6.07 -0.35 4.42e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4803468 1.000 rs1473248 chr19:41923314 C/T cg08639244 chr19:41945921 ATP5SL 0.41 5.03 0.3 9.08e-7 Height; CESC cis rs933688 1.000 rs11950530 chr5:90688740 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 12.36 0.6 5.17e-28 Smoking behavior; CESC cis rs8067545 0.611 rs9902032 chr17:20015178 G/C cg13482628 chr17:19912719 NA 0.41 5.34 0.31 2e-7 Schizophrenia; CESC cis rs7520050 0.966 rs785491 chr1:46583418 G/A cg03146154 chr1:46216737 IPP -0.43 -5.57 -0.32 6.33e-8 Red blood cell count;Reticulocyte count; CESC cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg24110177 chr3:50126178 RBM5 0.59 8.32 0.46 4.75e-15 Body mass index; CESC cis rs7264396 0.580 rs6119655 chr20:34412049 G/A cg17201900 chr20:34330562 RBM39 0.52 5.2 0.3 3.98e-7 Total cholesterol levels; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg01766191 chr11:57103423 SSRP1 -0.45 -6.64 -0.38 1.77e-10 Breast cancer; CESC cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg04267008 chr7:1944627 MAD1L1 -0.48 -5.67 -0.33 3.68e-8 Schizophrenia; CESC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg06456125 chr7:65229604 NA -0.39 -5.09 -0.3 6.82e-7 Aortic root size; CESC cis rs3820068 0.603 rs3766163 chr1:15986547 T/C cg18133145 chr1:16060689 PLEKHM2 -0.4 -5.21 -0.3 3.86e-7 Systolic blood pressure; CESC cis rs4423214 0.840 rs1792233 chr11:71182179 G/A cg05163923 chr11:71159392 DHCR7 -0.65 -7.66 -0.43 3.55e-13 Vitamin D levels; CESC cis rs938554 0.779 rs7442295 chr4:9966380 A/G cg00071950 chr4:10020882 SLC2A9 -0.47 -5.55 -0.32 7.04e-8 Blood metabolite levels; CESC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg01238044 chr22:24384105 GSTT1 0.48 6.03 0.35 5.47e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4568518 0.710 rs6966083 chr7:18016544 G/T cg03009463 chr7:17980271 SNX13 0.44 5.76 0.33 2.3e-8 Measles; CESC trans rs4245128 0.930 rs9666469 chr11:112787696 C/G cg10894232 chr8:11772343 NA 0.37 6.04 0.35 5.15e-9 Life satisfaction; CESC cis rs3733585 0.631 rs4697924 chr4:10124239 A/G cg00071950 chr4:10020882 SLC2A9 -0.63 -9.18 -0.49 1.25e-17 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10883723 0.810 rs10786669 chr10:104256094 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs13106227 0.550 rs11723732 chr4:77370557 A/G cg27417997 chr4:77356416 SHROOM3 -0.33 -5.08 -0.3 7.19e-7 Eosinophilic esophagitis (pediatric); CESC cis rs2439831 0.850 rs544122 chr15:43775732 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 9.72 0.51 2.7e-19 Lung cancer in ever smokers; CESC cis rs829661 0.947 rs829665 chr2:30724701 T/A cg07150166 chr2:30669952 LCLAT1 0.86 7.36 0.41 2.38e-12 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs4076764 0.957 rs4443867 chr1:163434917 T/C cg24596788 chr1:163392923 NA -0.47 -6.88 -0.39 4.18e-11 Motion sickness; CESC cis rs3820068 0.603 rs67349836 chr1:15966176 T/C cg13390004 chr1:15929781 NA 0.36 5.66 0.33 3.95e-8 Systolic blood pressure; CESC cis rs796364 0.806 rs74724807 chr2:201005109 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -6.83 -0.39 5.71e-11 Schizophrenia; CESC cis rs7208859 0.623 rs55811708 chr17:29104731 G/T cg19761014 chr17:28927070 LRRC37B2 0.75 6.17 0.35 2.49e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4727027 0.704 rs7784122 chr7:148904624 A/G cg23583168 chr7:148888333 NA 0.95 16.99 0.72 2.7e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg11494091 chr17:61959527 GH2 0.72 12.37 0.61 4.59e-28 Prudent dietary pattern; CESC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs9902453 1.000 rs4350617 chr17:28423088 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 7.93 0.44 6.25e-14 Coffee consumption (cups per day); CESC cis rs61931739 0.500 rs7963282 chr12:34535255 A/C cg06521331 chr12:34319734 NA -0.37 -5.15 -0.3 5.19e-7 Morning vs. evening chronotype; CESC trans rs1814175 0.817 rs11040700 chr11:50023832 C/T cg03929089 chr4:120376271 NA -0.94 -16.01 -0.7 7.75e-41 Height; CESC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg16325326 chr1:53192061 ZYG11B -0.9 -15.33 -0.69 2.02e-38 Monocyte count; CESC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.6 0.38 2.27e-10 Bipolar disorder; CESC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs2859741 0.967 rs535876 chr1:37484052 C/G cg09363841 chr1:37513479 NA -0.61 -9.61 -0.51 5.8e-19 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg15369054 chr17:80825471 TBCD 0.58 8.17 0.45 1.24e-14 Breast cancer; CESC cis rs6061231 0.631 rs2427318 chr20:60975727 G/T cg23531748 chr20:60969906 CABLES2 0.39 5.41 0.32 1.41e-7 Colorectal cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16973203 chr2:230876010 FBXO36 0.41 6.07 0.35 4.51e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.81 0.34 1.79e-8 Intelligence (multi-trait analysis); CESC cis rs2075371 0.644 rs1643041 chr7:134012211 C/T cg20476274 chr7:133979776 SLC35B4 0.51 6.63 0.38 1.87e-10 Mean platelet volume; CESC cis rs637571 0.522 rs538954 chr11:65756808 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 10.61 0.55 3.86e-22 Eosinophil percentage of white cells; CESC trans rs8073060 0.586 rs8074800 chr17:33979148 A/G cg19694781 chr19:47549865 TMEM160 0.67 7.05 0.4 1.51e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04215179 chr7:23719682 C7orf46 0.55 6.53 0.37 3.42e-10 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25547957 chr6:73972768 KHDC1 -0.51 -6.28 -0.36 1.4e-9 Ulcerative colitis; CESC cis rs2228479 0.702 rs62053702 chr16:89860688 G/T cg00800038 chr16:89945340 TCF25 -0.9 -7.49 -0.42 1.01e-12 Skin colour saturation; CESC cis rs1538970 0.924 rs12097497 chr1:45880669 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.36 0.31 1.85e-7 Platelet count; CESC cis rs3736485 0.966 rs7182977 chr15:51854130 C/G cg08986416 chr15:51914746 DMXL2 -0.4 -5.13 -0.3 5.5e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs287982 0.800 rs9973905 chr2:9960855 G/C cg10881225 chr2:9984929 TAF1B 0.41 5.25 0.31 3.05e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg17279839 chr7:150038598 RARRES2 0.5 5.91 0.34 1.04e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs11098499 0.909 rs28571712 chr4:120375980 G/A cg09307838 chr4:120376055 NA 0.92 12.73 0.62 2.68e-29 Corneal astigmatism; CESC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg02475777 chr4:1388615 CRIPAK -0.46 -5.98 -0.34 7.12e-9 Obesity-related traits; CESC cis rs7107174 1.000 rs2511158 chr11:77973980 C/T cg02023728 chr11:77925099 USP35 0.48 6.34 0.36 9.87e-10 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25605771 chr1:44466601 SLC6A9 -0.63 -6.97 -0.39 2.53e-11 Gut microbiome composition (summer); CESC cis rs5753037 0.702 rs140100 chr22:30128240 C/T cg01021169 chr22:30184971 ASCC2 -0.46 -6.17 -0.35 2.55e-9 Type 1 diabetes; CESC cis rs9916302 0.652 rs9903269 chr17:37742383 A/T cg07936489 chr17:37558343 FBXL20 -0.87 -8.8 -0.48 1.82e-16 Glomerular filtration rate (creatinine); CESC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg17340268 chr14:105411764 AHNAK2 -0.52 -6.85 -0.39 5.2e-11 Rheumatoid arthritis; CESC cis rs11098499 0.909 rs28884220 chr4:120307211 A/G cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg22433210 chr17:43662623 NA -0.58 -7.35 -0.41 2.52e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg05340658 chr4:99064831 C4orf37 0.84 12.86 0.62 1.01e-29 Colonoscopy-negative controls vs population controls; CESC cis rs1003719 0.680 rs2835670 chr21:38581114 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.07 -0.44 2.45e-14 Eye color traits; CESC cis rs116095464 0.558 rs62347678 chr5:227496 A/G cg22496380 chr5:211416 CCDC127 -0.72 -8.45 -0.46 1.92e-15 Breast cancer; CESC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg17376030 chr22:41985996 PMM1 0.69 7.53 0.42 8.22e-13 Vitiligo; CESC cis rs4919694 1.000 rs11191545 chr10:104829793 C/T cg04362960 chr10:104952993 NT5C2 0.76 6.71 0.38 1.19e-10 Arsenic metabolism; CESC cis rs3806843 0.518 rs2563310 chr5:140015741 A/G cg26395211 chr5:140044315 WDR55 0.41 5.19 0.3 4.13e-7 Depressive symptoms (multi-trait analysis); CESC cis rs644799 0.710 rs12273579 chr11:95524421 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.14 0.56 6.71e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9796 0.689 rs8032195 chr15:41448790 G/A cg20272979 chr15:41787780 ITPKA 0.34 5.14 0.3 5.42e-7 Menopause (age at onset); CESC cis rs7512552 0.780 rs2794681 chr1:150321951 C/T cg15654264 chr1:150340011 RPRD2 0.39 5.12 0.3 5.94e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25936770 chr7:122321411 CADPS2 0.47 6.55 0.37 2.89e-10 Fibrinogen levels; CESC trans rs2727020 0.729 rs2299650 chr11:49174007 A/C cg03929089 chr4:120376271 NA -0.78 -11.88 -0.59 2.2e-26 Coronary artery disease; CESC cis rs1534166 0.647 rs9853615 chr3:133519981 C/T cg12373951 chr3:133503437 NA 0.35 5.26 0.31 3.04e-7 Alcohol consumption (transferrin glycosylation); CESC cis rs9487051 0.676 rs1608044 chr6:109594076 T/C cg12927641 chr6:109611667 NA -0.37 -5.57 -0.32 6.16e-8 Reticulocyte fraction of red cells; CESC cis rs708547 0.581 rs6554400 chr4:57805306 A/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.52 -7.03 -0.4 1.71e-11 Response to bleomycin (chromatid breaks); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19268579 chr10:43904406 HNRNPF -0.47 -6.01 -0.35 5.97e-9 Ulcerative colitis; CESC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.65 0.38 1.71e-10 Prudent dietary pattern; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg19757253 chr2:32853039 TTC27 -0.52 -6.22 -0.36 1.97e-9 Lung cancer in ever smokers; CESC cis rs12042938 0.935 rs1094657 chr1:231773407 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.45 6.18 0.35 2.39e-9 Neuranatomic and neurocognitive phenotypes; CESC cis rs546131 0.928 rs558967 chr11:34827168 T/A cg11058730 chr11:34937778 PDHX;APIP 0.46 5.82 0.34 1.65e-8 Lung disease severity in cystic fibrosis; CESC cis rs6088580 0.634 rs6579165 chr20:32994715 A/G cg08999081 chr20:33150536 PIGU -0.65 -11.29 -0.57 2.22e-24 Glomerular filtration rate (creatinine); CESC cis rs6088590 1.000 rs11698977 chr20:33449691 C/T cg08999081 chr20:33150536 PIGU 0.58 8.91 0.48 8.59e-17 Coronary artery disease; CESC trans rs61931739 0.517 rs1586409 chr12:34046614 C/A cg26384229 chr12:38710491 ALG10B 0.53 7.22 0.41 5.44e-12 Morning vs. evening chronotype; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12536451 chr10:99496852 ZFYVE27 0.5 6.75 0.38 9.24e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg04234412 chr22:24373322 LOC391322 -0.63 -9.2 -0.49 1.11e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4604732 0.588 rs7552443 chr1:247628583 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 6.01 0.35 6.07e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9911578 0.933 rs2531726 chr17:56522533 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.14 -0.3 5.35e-7 Intelligence (multi-trait analysis); CESC cis rs36051895 0.632 rs12349918 chr9:5125250 A/G cg02405213 chr9:5042618 JAK2 -0.54 -6.47 -0.37 4.66e-10 Pediatric autoimmune diseases; CESC cis rs4660261 0.561 rs11210934 chr1:44369435 G/A cg12908607 chr1:44402522 ARTN -0.49 -7.52 -0.42 8.28e-13 Intelligence (multi-trait analysis); CESC cis rs6032067 0.673 rs36019441 chr20:43892401 G/A cg10761708 chr20:43804764 PI3 0.41 5.14 0.3 5.43e-7 Blood protein levels; CESC cis rs1348850 0.567 rs3770005 chr2:178528874 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 6.95 0.39 2.88e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.68 0.61 4e-29 Gut microbiome composition (summer); CESC cis rs12188164 0.582 rs72700694 chr5:483267 T/C cg15813090 chr5:442598 EXOC3;C5orf55 0.4 5.64 0.33 4.32e-8 Cystic fibrosis severity; CESC cis rs933688 0.556 rs4916855 chr5:90596345 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.52 -6.22 -0.36 1.89e-9 Smoking behavior; CESC cis rs1348850 0.914 rs10170667 chr2:178336878 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.89 12.75 0.62 2.42e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4843747 0.671 rs13334603 chr16:88116016 T/C cg03395651 chr16:88107091 BANP 0.45 5.12 0.3 5.76e-7 Menopause (age at onset); CESC cis rs4689388 0.581 rs1801212 chr4:6302519 C/T cg00701064 chr4:6280414 WFS1 0.55 7.0 0.4 2.05e-11 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9911578 1.000 rs9901181 chr17:56964271 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -6.95 -0.39 2.9100000000000002e-11 Intelligence (multi-trait analysis); CESC cis rs4654899 0.802 rs10916903 chr1:21247944 T/C cg05370193 chr1:21551575 ECE1 0.39 5.63 0.33 4.62e-8 Superior frontal gyrus grey matter volume; CESC cis rs9916302 0.904 rs1966916 chr17:37425238 T/G cg20243544 chr17:37824526 PNMT 0.46 5.76 0.33 2.31e-8 Glomerular filtration rate (creatinine); CESC cis rs858239 0.669 rs10950940 chr7:23196816 C/T cg27449745 chr7:23145252 KLHL7 0.41 5.22 0.31 3.6e-7 Cerebrospinal fluid biomarker levels; CESC cis rs11098499 0.863 rs13140391 chr4:120503437 A/G cg09307838 chr4:120376055 NA 0.95 12.98 0.62 3.72e-30 Corneal astigmatism; CESC cis rs938554 0.736 rs4475146 chr4:9946656 C/A cg00071950 chr4:10020882 SLC2A9 -0.51 -5.95 -0.34 8.36e-9 Blood metabolite levels; CESC cis rs926938 0.618 rs360624 chr1:115409476 A/C cg12756093 chr1:115239321 AMPD1 0.51 7.34 0.41 2.61e-12 Autism; CESC cis rs2404602 0.669 rs17367297 chr15:77158026 A/C cg22467129 chr15:76604101 ETFA -0.35 -5.27 -0.31 2.8e-7 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17513182 chr1:153894941 GATAD2B 0.57 6.19 0.36 2.26e-9 Gut microbiome composition (summer); CESC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg11644478 chr21:40555479 PSMG1 -0.75 -10.59 -0.55 4.51e-22 Cognitive function; CESC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg24308560 chr3:49941425 MST1R -0.5 -6.87 -0.39 4.66e-11 Body mass index; CESC cis rs10883723 0.518 rs10786679 chr10:104315667 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.46 5.61 0.33 5.12e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs12936587 0.535 rs6502615 chr17:17612023 C/T cg04398451 chr17:18023971 MYO15A 0.38 5.15 0.3 5.19e-7 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CESC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg10074409 chr1:209979377 IRF6 -0.37 -5.87 -0.34 1.32e-8 Cleft lip with or without cleft palate; CESC cis rs868036 1.000 rs1026731 chr15:68095018 G/A cg08079166 chr15:68083412 MAP2K5 0.44 6.94 0.39 2.94e-11 Restless legs syndrome; CESC cis rs6584283 0.846 rs7917446 chr10:101286207 T/C cg09788492 chr10:101292477 NKX2-3 0.33 6.15 0.35 2.87e-9 Ulcerative colitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00093436 chr1:36172279 NA -0.4 -6.1 -0.35 3.66e-9 Gambling; CESC cis rs11997175 0.587 rs72612118 chr8:33695225 T/C ch.8.33884649F chr8:33765107 NA 0.56 7.33 0.41 2.82e-12 Body mass index; CESC cis rs11030122 0.673 rs4910597 chr11:4094923 G/A cg18678763 chr11:4115507 RRM1 -0.53 -6.97 -0.39 2.51e-11 Mean platelet volume;Platelet distribution width; CESC cis rs7923609 0.967 rs2393977 chr10:65247609 A/C cg01631684 chr10:65280961 REEP3 -0.43 -5.4 -0.31 1.49e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs1018697 0.518 rs2790914 chr10:104568018 C/T cg04362960 chr10:104952993 NT5C2 -0.58 -6.42 -0.37 6.35e-10 Colorectal adenoma (advanced); CESC trans rs9329221 0.537 rs6995859 chr8:9975709 T/A cg06636001 chr8:8085503 FLJ10661 0.49 6.2 0.36 2.18e-9 Neuroticism; CESC cis rs9796 0.621 rs2928142 chr15:41470449 T/C cg18705301 chr15:41695430 NDUFAF1 0.44 6.46 0.37 4.86e-10 Menopause (age at onset); CESC cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg19077165 chr18:44547161 KATNAL2 0.65 10.03 0.52 2.79e-20 Personality dimensions; CESC cis rs1707322 0.721 rs4415615 chr1:46132109 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.12 0.4 1.04e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1593 0.734 rs4862670 chr4:187145423 A/T cg09526685 chr4:187126073 CYP4V2 0.61 5.03 0.3 9e-7 Activated partial thromboplastin time; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg04407147 chr2:160606257 MARCH7 0.41 6.38 0.36 7.79e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9815354 1.000 rs73081353 chr3:41906448 T/A cg03022575 chr3:42003672 ULK4 0.57 5.88 0.34 1.2e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs8067545 1.000 rs28807825 chr17:19942850 G/A cg13482628 chr17:19912719 NA 0.43 5.78 0.33 2.07e-8 Schizophrenia; CESC cis rs765787 0.530 rs1706764 chr15:45524256 T/A cg24006582 chr15:45444508 DUOX1 -0.58 -7.08 -0.4 1.26e-11 Uric acid levels; CESC cis rs9611565 0.694 rs2142505 chr22:41820541 A/G cg03806693 chr22:41940476 POLR3H 1.21 14.54 0.67 1.31e-35 Vitiligo; CESC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg11663144 chr21:46675770 NA 0.63 9.94 0.52 5.51e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15322430 chr1:40157251 HPCAL4 0.58 6.39 0.37 7.23e-10 Gut microbiome composition (summer); CESC cis rs9894429 1.000 rs12948099 chr17:79600799 C/G cg21984481 chr17:79567631 NPLOC4 -0.49 -7.96 -0.44 4.9e-14 Eye color traits; CESC cis rs6587515 0.901 rs12045807 chr1:150584834 C/T cg13175981 chr1:150552382 MCL1 0.59 5.62 0.33 4.75e-8 Pericardial adipose tissue adjusted for height and weight; CESC cis rs1506636 0.720 rs633590 chr7:123442156 G/A cg03229431 chr7:123269106 ASB15 0.39 5.19 0.3 4.15e-7 Plateletcrit;Platelet count; CESC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg03388025 chr16:89894329 SPIRE2 0.41 7.8 0.43 1.45e-13 Vitiligo; CESC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.48 6.05 0.35 4.83e-9 Tonsillectomy; CESC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg01416388 chr22:39784598 NA -0.58 -7.11 -0.4 1.1e-11 Intelligence (multi-trait analysis); CESC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg05863683 chr7:1912471 MAD1L1 0.37 5.49 0.32 9.51e-8 Bipolar disorder and schizophrenia; CESC cis rs11958404 0.719 rs72818153 chr5:157487035 T/C cg05962755 chr5:157440814 NA 0.63 7.31 0.41 3.13e-12 IgG glycosylation; CESC cis rs9911578 1.000 rs3744109 chr17:56594197 C/T cg12560992 chr17:57184187 TRIM37 -0.93 -15.59 -0.69 2.43e-39 Intelligence (multi-trait analysis); CESC cis rs2845885 0.793 rs56241103 chr11:63882364 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.81 9.49 0.5 1.39e-18 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16411216 chr1:9340507 NA 0.55 6.23 0.36 1.8e-9 Gut microbiome composition (summer); CESC cis rs7918232 0.830 rs7915902 chr10:27410734 T/C cg14240646 chr10:27532245 ACBD5 -0.66 -6.43 -0.37 5.89e-10 Breast cancer; CESC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs72781680 1.000 rs74704838 chr2:24158270 C/A cg20701182 chr2:24300061 SF3B14 0.65 5.81 0.34 1.79e-8 Lymphocyte counts; CESC cis rs7680126 0.536 rs3796841 chr4:10007904 C/T cg00071950 chr4:10020882 SLC2A9 0.58 5.75 0.33 2.41e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1577917 1.000 rs10944169 chr6:86683036 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.07 -0.35 4.5e-9 Response to antipsychotic treatment; CESC cis rs709400 0.663 rs10141388 chr14:103939679 A/G cg12935359 chr14:103987150 CKB -0.47 -6.87 -0.39 4.58e-11 Body mass index; CESC cis rs3733585 0.699 rs28610447 chr4:9971517 T/C cg00071950 chr4:10020882 SLC2A9 -0.69 -11.32 -0.57 1.7e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 5.97 0.34 7.58e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs116095464 0.558 rs56127718 chr5:270273 G/T cg20965017 chr5:231967 SDHA -0.48 -5.44 -0.32 1.22e-7 Breast cancer; CESC cis rs6570726 0.791 rs414297 chr6:145887556 C/T cg05347473 chr6:146136440 FBXO30 0.54 7.09 0.4 1.24e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7296418 0.699 rs11057254 chr12:123794581 A/C cg00376283 chr12:123451042 ABCB9 0.57 7.82 0.43 1.23e-13 Platelet count; CESC trans rs9325144 0.723 rs3887436 chr12:39189526 A/C cg23762105 chr12:34175262 ALG10 0.45 6.14 0.35 3.01e-9 Morning vs. evening chronotype; CESC cis rs921968 0.643 rs833083 chr2:219336959 A/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.99 -0.39 2.26e-11 Mean corpuscular hemoglobin concentration; CESC cis rs2463822 1.000 rs2513074 chr11:62100880 A/C cg06239285 chr11:62104954 ASRGL1 0.89 8.97 0.48 5.69e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2228479 0.867 rs57492102 chr16:89975572 A/G cg06558623 chr16:89946397 TCF25 0.9 7.89 0.44 7.95e-14 Skin colour saturation; CESC cis rs9908102 0.740 rs73298506 chr17:12904119 G/A cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs11098499 0.909 rs28668716 chr4:120309875 T/C cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs9911578 1.000 rs12952832 chr17:56906254 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.53e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2425143 0.908 rs6060632 chr20:34422601 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -6.14 -0.35 3.05e-9 Blood protein levels; CESC cis rs12079745 0.590 rs12095526 chr1:169401827 A/G cg09363564 chr1:169337483 NME7;BLZF1 -1.26 -7.33 -0.41 2.72e-12 QT interval; CESC cis rs9488822 0.636 rs12201275 chr6:116314563 C/G cg05304507 chr6:116381966 FRK 0.24 6.26 0.36 1.53e-9 Cholesterol, total;LDL cholesterol; CESC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg17372223 chr3:52568218 NT5DC2 0.42 6.42 0.37 6.09e-10 Bipolar disorder; CESC cis rs728616 0.867 rs4387301 chr10:81736399 C/T cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs763014 0.838 rs4984670 chr16:641044 A/G cg07597022 chr16:675116 RAB40C -0.31 -5.03 -0.3 8.85e-7 Height; CESC cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg05347473 chr6:146136440 FBXO30 0.59 7.56 0.42 6.43e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg18180107 chr4:99064573 C4orf37 0.42 5.23 0.31 3.45e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4835473 0.932 rs7690428 chr4:144706553 A/G cg25736465 chr4:144833511 NA -0.33 -5.43 -0.32 1.28e-7 Immature fraction of reticulocytes; CESC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg00149659 chr3:10157352 C3orf10 0.72 9.05 0.49 3.26e-17 Alzheimer's disease; CESC cis rs67311347 1.000 rs9874499 chr3:40441908 C/T cg24209194 chr3:40518798 ZNF619 0.43 5.42 0.32 1.35e-7 Renal cell carcinoma; CESC cis rs62064224 0.554 rs9901737 chr17:30681354 C/G cg18200150 chr17:30822561 MYO1D 0.38 5.11 0.3 6.22e-7 Schizophrenia; CESC cis rs9815354 0.723 rs61182696 chr3:42032511 C/T cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.48 6.11 0.35 3.49e-9 Tonsillectomy; CESC cis rs12476592 0.602 rs10168545 chr2:63734284 C/A cg17519650 chr2:63277830 OTX1 -0.48 -5.59 -0.32 5.6e-8 Childhood ear infection; CESC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg25204440 chr1:209979598 IRF6 0.67 7.93 0.44 6.35e-14 Cleft lip with or without cleft palate; CESC cis rs6570726 0.791 rs6570693 chr6:145910841 C/T cg23711669 chr6:146136114 FBXO30 0.92 13.58 0.64 3.16e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs1707322 0.638 rs1707302 chr1:46600917 A/G cg06784218 chr1:46089804 CCDC17 -0.32 -5.16 -0.3 4.84e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs208520 0.526 rs1385219 chr6:66754476 C/T cg07460842 chr6:66804631 NA 1.01 21.14 0.79 8.4e-59 Exhaled nitric oxide output; CESC cis rs1577917 1.000 rs12207305 chr6:86723502 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.03 -0.35 5.34e-9 Response to antipsychotic treatment; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14393411 chr19:13067586 GADD45GIP1 0.5 6.75 0.38 9.21e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs732765 0.602 rs2359192 chr14:75410523 A/C cg06642626 chr14:75180534 FCF1;KIAA0317 0.36 5.31 0.31 2.37e-7 Non-small cell lung cancer; CESC cis rs8180040 0.726 rs11130110 chr3:47000606 T/C cg27129171 chr3:47204927 SETD2 0.66 9.63 0.51 4.97e-19 Colorectal cancer; CESC cis rs6964587 0.967 rs28399886 chr7:91638451 A/G cg17063962 chr7:91808500 NA 0.58 8.01 0.44 3.65e-14 Breast cancer; CESC cis rs9325144 0.577 rs12314639 chr12:39119869 T/C cg26384229 chr12:38710491 ALG10B -0.54 -7.43 -0.42 1.48e-12 Morning vs. evening chronotype; CESC cis rs5758659 1.000 rs134882 chr22:42670965 A/G cg15557168 chr22:42548783 NA -0.5 -8.05 -0.44 2.74e-14 Cognitive function; CESC cis rs7208859 0.623 rs28627615 chr17:29145817 G/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7937682 1.000 rs7128353 chr11:111538875 A/G cg09085632 chr11:111637200 PPP2R1B -0.98 -15.54 -0.69 3.81e-39 Primary sclerosing cholangitis; CESC cis rs5763662 1.000 rs34474867 chr22:30563301 C/T cg21388335 chr22:29999516 NF2 -0.74 -5.04 -0.3 8.8e-7 LDL cholesterol levels;LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11587315 chr1:223254976 NA 0.6 6.88 0.39 4.33e-11 Gut microbiome composition (summer); CESC cis rs2625529 0.652 rs2957735 chr15:72265173 T/C cg16672083 chr15:72433130 SENP8 0.46 6.78 0.38 7.68e-11 Red blood cell count; CESC trans rs61931739 0.500 rs7311302 chr12:34557211 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.74e-12 Morning vs. evening chronotype; CESC cis rs8077889 1.000 rs2342310 chr17:41866199 T/C cg26893861 chr17:41843967 DUSP3 0.85 9.86 0.52 1e-19 Triglycerides; CESC cis rs4253772 0.530 rs9615958 chr22:46751122 A/G cg24881330 chr22:46731750 TRMU 0.75 5.75 0.33 2.46e-8 LDL cholesterol;Cholesterol, total; CESC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg26939375 chr7:64535504 NA 0.66 9.52 0.5 1.17e-18 Calcium levels; CESC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg11644478 chr21:40555479 PSMG1 0.95 14.21 0.66 1.96e-34 Cognitive function; CESC cis rs1570884 0.516 rs9316462 chr13:50176321 A/G cg08779649 chr13:50194554 NA 0.39 6.71 0.38 1.17e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs2066819 0.901 rs1274490 chr12:56649601 A/G cg26316697 chr12:56727976 PAN2 -0.7 -6.79 -0.39 7.22e-11 Psoriasis vulgaris; CESC cis rs7267979 0.549 rs11698185 chr20:25181998 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.66 10.57 0.54 4.93e-22 Liver enzyme levels (alkaline phosphatase); CESC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.42 0.32 1.32e-7 Menopause (age at onset); CESC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg19163074 chr7:65112434 INTS4L2 0.41 5.24 0.31 3.26e-7 Aortic root size; CESC cis rs910316 0.763 rs2080201 chr14:75629972 C/T cg11812906 chr14:75593930 NEK9 -0.79 -12.24 -0.6 1.36e-27 Height; CESC cis rs722599 0.683 rs17102847 chr14:75324780 A/G cg11812906 chr14:75593930 NEK9 -0.46 -5.68 -0.33 3.46e-8 IgG glycosylation; CESC cis rs4253772 0.575 rs9615364 chr22:46797503 G/A cg24881330 chr22:46731750 TRMU 0.67 5.27 0.31 2.76e-7 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg24829409 chr8:58192753 C8orf71 -0.75 -9.95 -0.52 5.19e-20 Developmental language disorder (linguistic errors); CESC cis rs11711311 1.000 rs12736 chr3:113530211 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.68 9.39 0.5 2.79e-18 IgG glycosylation; CESC cis rs11190604 1.000 rs10883493 chr10:102208188 A/T cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs17536732 0.685 rs79983181 chr4:162859282 C/A cg12177677 chr2:158300475 CYTIP -0.63 -6.2 -0.36 2.17e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs4561483 0.549 rs33657 chr16:11969724 G/C cg08843971 chr16:11963173 GSPT1 -0.53 -7.56 -0.42 6.61e-13 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00098451 chr1:16370634 CLCNKB -0.56 -7.29 -0.41 3.62e-12 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs4835473 0.932 rs17763107 chr4:144749665 A/G cg25736465 chr4:144833511 NA -0.45 -6.75 -0.38 9.22e-11 Immature fraction of reticulocytes; CESC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg19318889 chr4:1322082 MAEA 0.59 7.05 0.4 1.53e-11 Longevity; CESC cis rs6912958 1.000 rs6937823 chr6:88160386 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.32 -0.45 4.79e-15 Monocyte percentage of white cells; CESC cis rs4955124 0.558 rs62244396 chr3:32023779 T/C cg05935571 chr3:32023257 ZNF860;OSBPL10 0.99 7.96 0.44 5.07e-14 Schizophrenia; CESC cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg00409905 chr10:38381863 ZNF37A -0.48 -6.39 -0.37 7.55e-10 Extrinsic epigenetic age acceleration; CESC cis rs2243480 0.901 rs58207111 chr7:65486723 C/T cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC trans rs116095464 0.558 rs1971229 chr5:268187 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.38e-11 Breast cancer; CESC cis rs4888262 0.526 rs4887772 chr16:74537591 C/T cg01733217 chr16:74700730 RFWD3 0.81 11.32 0.57 1.68e-24 Testicular germ cell tumor; CESC cis rs12325245 0.536 rs35832551 chr16:58591444 G/T cg02549819 chr16:58548995 SETD6 0.96 6.42 0.37 6.42e-10 Schizophrenia; CESC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg14820908 chr5:178986412 RUFY1 0.5 7.84 0.43 1.12e-13 Lung cancer; CESC cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.64 8.08 0.44 2.36e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.59 0.47 7.62e-16 Colonoscopy-negative controls vs population controls; CESC cis rs13256369 0.802 rs13280101 chr8:8562773 G/A cg17143192 chr8:8559678 CLDN23 0.77 8.67 0.47 4.32e-16 Obesity-related traits; CESC cis rs7727544 0.606 rs10060615 chr5:131708877 T/C cg14196790 chr5:131705035 SLC22A5 0.36 5.44 0.32 1.18e-7 Blood metabolite levels; CESC cis rs10751667 0.643 rs10794352 chr11:946294 T/C cg06064525 chr11:970664 AP2A2 -0.49 -9.82 -0.52 1.26e-19 Alzheimer's disease (late onset); CESC cis rs9905704 0.918 rs186221 chr17:56695967 C/T cg12560992 chr17:57184187 TRIM37 0.59 6.98 0.39 2.34e-11 Testicular germ cell tumor; CESC cis rs1941023 0.503 rs7952244 chr11:60132164 G/A cg08716584 chr11:60157161 MS4A7 -0.55 -8.95 -0.48 6.42e-17 Congenital heart disease (maternal effect); CESC cis rs1538970 0.924 rs2088100 chr1:45877575 C/T cg24296786 chr1:45957014 TESK2 -0.45 -5.22 -0.31 3.64e-7 Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10113582 chr4:905918 GAK 0.45 6.06 0.35 4.6e-9 Fibrinogen levels; CESC cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg09060608 chr5:178986726 RUFY1 0.51 7.79 0.43 1.5700000000000001e-13 Lung cancer; CESC cis rs9527 1.000 rs9527 chr10:104623578 C/T cg04362960 chr10:104952993 NT5C2 0.51 5.48 0.32 9.8e-8 Arsenic metabolism; CESC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg08822215 chr16:89438651 ANKRD11 -0.34 -5.11 -0.3 6.26e-7 Multiple myeloma (IgH translocation); CESC cis rs72634258 0.554 rs4562654 chr1:7934423 A/T cg00042356 chr1:8021962 PARK7 0.6 5.95 0.34 8.6e-9 Inflammatory bowel disease; CESC cis rs5769707 0.616 rs135869 chr22:50008366 T/C cg20744362 chr22:50050164 C22orf34 0.38 5.26 0.31 2.97e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs116095464 0.558 rs6555055 chr5:226160 A/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.58 0.32 5.88e-8 Breast cancer; CESC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg08888203 chr3:10149979 C3orf24 0.42 5.1 0.3 6.38e-7 Alzheimer's disease; CESC cis rs12464559 0.522 rs11676866 chr2:152628858 G/C cg01189475 chr2:152685088 ARL5A 0.72 7.17 0.4 7.48e-12 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs2637266 0.935 rs12259550 chr10:78352843 A/G cg18941641 chr10:78392320 NA 0.41 7.55 0.42 7.02e-13 Pulmonary function; CESC cis rs8060686 0.920 rs2292316 chr16:67861134 C/G cg26727032 chr16:67993705 SLC12A4 0.58 6.39 0.37 7.27e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs861020 0.630 rs657861 chr1:210006884 C/G cg05527609 chr1:210001259 C1orf107 0.72 9.41 0.5 2.51e-18 Orofacial clefts; CESC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg27121462 chr16:89883253 FANCA 0.82 12.35 0.6 5.75e-28 Vitiligo; CESC cis rs13095912 1.000 rs10937226 chr3:185302885 G/A cg11274856 chr3:185301563 NA 0.35 5.7 0.33 3.24e-8 Systolic blood pressure; CESC cis rs959260 0.925 rs9901434 chr17:73388770 A/G cg12999837 chr17:73267436 MIF4GD -0.51 -5.74 -0.33 2.57e-8 Systemic lupus erythematosus; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18046570 chr17:26368374 NLK 0.46 6.44 0.37 5.6e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6691722 0.503 rs3765427 chr1:24705567 G/A cg18323236 chr1:24743029 NIPAL3 0.39 5.7 0.33 3.12e-8 Response to interferon beta in multiple sclerosis; CESC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg11644478 chr21:40555479 PSMG1 -0.5 -6.82 -0.39 6.23e-11 Menarche (age at onset); CESC cis rs2243480 1.000 rs316322 chr7:65611233 G/C cg18252515 chr7:66147081 NA -1.41 -14.47 -0.66 2.25e-35 Diabetic kidney disease; CESC cis rs11255291 0.668 rs4749169 chr10:7737661 G/C cg26051552 chr10:7670683 ITIH5 0.36 5.15 0.3 5e-7 Ovarian reserve; CESC cis rs4889855 0.530 rs4477776 chr17:78581765 G/A cg16591659 chr17:78472290 NA -0.31 -5.15 -0.3 5.08e-7 Fractional excretion of uric acid; CESC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg21782813 chr7:2030301 MAD1L1 0.49 7.01 0.4 1.98e-11 Bipolar disorder and schizophrenia; CESC cis rs9896933 0.723 rs7224189 chr17:80782227 C/T cg20578329 chr17:80767326 TBCD -0.61 -6.69 -0.38 1.35e-10 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs1707322 1.000 rs10890381 chr1:46451771 T/G cg03146154 chr1:46216737 IPP 0.78 10.77 0.55 1.17e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg26859690 chr20:3869672 PANK2 0.46 6.25 0.36 1.63e-9 Bronchopulmonary dysplasia; CESC cis rs9902453 0.836 rs62070337 chr17:28466257 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 8.02 0.44 3.41e-14 Coffee consumption (cups per day); CESC cis rs4835473 0.838 rs56033497 chr4:144713494 A/T cg25736465 chr4:144833511 NA -0.36 -5.86 -0.34 1.4e-8 Immature fraction of reticulocytes; CESC cis rs10045504 0.502 rs17456198 chr5:38732005 A/G cg15396434 chr5:38725168 NA -0.66 -6.41 -0.37 6.49e-10 Night sleep phenotypes; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg15312298 chr8:127570908 FAM84B -0.43 -6.01 -0.35 6.09e-9 Height; CESC cis rs7927771 0.524 rs10838775 chr11:47856382 C/G cg18512352 chr11:47633146 NA 0.35 5.39 0.31 1.53e-7 Subjective well-being; CESC cis rs7267979 0.844 rs2474780 chr20:25285835 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.79 14.56 0.67 1.07e-35 Liver enzyme levels (alkaline phosphatase); CESC cis rs1707322 1.000 rs10890360 chr1:46338444 C/T cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs17407555 0.821 rs55851451 chr4:10139189 G/A cg00071950 chr4:10020882 SLC2A9 -0.62 -5.6 -0.33 5.37e-8 Schizophrenia (age at onset); CESC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg14773178 chr5:1868261 NA 0.32 5.58 0.32 6e-8 Cardiovascular disease risk factors; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21159473 chr9:15510228 PSIP1 0.57 6.92 0.39 3.33e-11 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg22800045 chr5:56110881 MAP3K1 0.81 9.74 0.51 2.33e-19 Initial pursuit acceleration; CESC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.1 -0.35 3.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8114671 0.527 rs3736802 chr20:33604042 T/C cg24642439 chr20:33292090 TP53INP2 -0.5 -6.2 -0.36 2.2e-9 Height; CESC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 10.1 0.53 1.71e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14677014 chr10:15001504 MEIG1 -0.46 -6.19 -0.36 2.23e-9 Fibrinogen levels; CESC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.58 0.55 4.6e-22 Prudent dietary pattern; CESC cis rs9911578 1.000 rs437732 chr17:56675861 A/C cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2361718 0.568 rs1042397 chr17:78092063 G/A cg27427491 chr17:78079615 GAA -0.37 -5.71 -0.33 3.09e-8 Yeast infection; CESC cis rs710216 0.917 rs1681859 chr1:43411829 G/A cg07803811 chr1:43423981 SLC2A1 0.49 5.19 0.3 4.12e-7 Red cell distribution width; CESC cis rs2380220 0.541 rs9285413 chr6:96023439 G/A cg04719120 chr6:96025338 MANEA 0.65 6.94 0.39 3.08e-11 Behavioural disinhibition (generation interaction); CESC cis rs1348850 0.567 rs880898 chr2:178532470 C/T cg22681709 chr2:178499509 PDE11A -0.48 -7.75 -0.43 1.95e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg18876405 chr7:65276391 NA -0.57 -7.55 -0.42 6.85e-13 Aortic root size; CESC cis rs9859260 0.744 rs557527 chr3:195780709 G/A cg12923728 chr3:195709715 SDHAP1 0.54 6.96 0.39 2.68e-11 Mean corpuscular volume; CESC cis rs7589342 0.628 rs9646959 chr2:106412191 A/G cg16077055 chr2:106428750 NCK2 -0.52 -6.57 -0.37 2.71e-10 Addiction; CESC cis rs892961 0.932 rs7224116 chr17:75413177 A/G cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs672059 0.513 rs572977 chr1:183164991 C/G cg05929019 chr1:183155154 LAMC2 -0.29 -5.37 -0.31 1.71e-7 Hypertriglyceridemia; CESC cis rs7917772 0.508 rs2252147 chr10:104467774 G/A cg04362960 chr10:104952993 NT5C2 -0.46 -5.04 -0.3 8.82e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs864537 0.646 rs1723016 chr1:167433056 T/C cg22356347 chr1:167427500 CD247 -0.37 -7.65 -0.43 3.84e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs8064299 0.655 rs734232 chr17:72765731 C/T cg25054828 chr17:72772726 NAT9;TMEM104 0.49 6.24 0.36 1.7e-9 Monocyte count; CESC cis rs2108225 0.934 rs2301989 chr7:107443871 G/A cg18560240 chr7:107437656 SLC26A3 -0.37 -5.13 -0.3 5.61e-7 Ulcerative colitis; CESC cis rs7726839 0.540 rs72703079 chr5:595173 T/C cg16447950 chr5:562315 NA -0.6 -6.08 -0.35 4.21e-9 Obesity-related traits; CESC cis rs9300255 0.544 rs1727310 chr12:123660510 A/G cg00376283 chr12:123451042 ABCB9 0.61 6.17 0.35 2.57e-9 Neutrophil percentage of white cells; CESC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg11764359 chr7:65958608 NA 0.96 15.03 0.68 2.41e-37 Aortic root size; CESC trans rs11098499 0.863 rs10004484 chr4:120442428 C/T cg25214090 chr10:38739885 LOC399744 0.71 9.82 0.52 1.35e-19 Corneal astigmatism; CESC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg26338869 chr17:61819248 STRADA 0.69 9.47 0.5 1.66e-18 Prudent dietary pattern; CESC cis rs10949834 0.540 rs810552 chr7:73489298 A/G cg07137043 chr7:73588983 EIF4H 0.59 7.05 0.4 1.59e-11 Verbal memory performance (residualized delayed recall change); CESC cis rs9931543 0.504 rs4784650 chr16:56306640 A/G cg02433656 chr16:56322654 GNAO1 0.39 5.06 0.3 7.68e-7 Subjective well-being; CESC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1559088 0.573 rs1270591 chr19:33622942 C/T cg27124370 chr19:33622961 WDR88 -0.52 -7.35 -0.41 2.41e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs372883 0.554 rs10154065 chr21:30749480 G/C cg24692254 chr21:30365293 RNF160 0.51 6.38 0.37 7.69e-10 Pancreatic cancer; CESC cis rs7659604 0.540 rs11098643 chr4:122701507 C/A cg19748678 chr4:122722346 EXOSC9 -0.43 -5.36 -0.31 1.84e-7 Type 2 diabetes; CESC cis rs367943 0.966 rs348924 chr5:112817930 T/G cg12552261 chr5:112820674 MCC -0.62 -7.78 -0.43 1.58e-13 Type 2 diabetes; CESC cis rs425277 0.565 rs61775448 chr1:2045376 A/G cg04315214 chr1:2043799 PRKCZ 0.62 11.23 0.57 3.43e-24 Height; CESC cis rs2267137 0.836 rs2283855 chr22:29796775 T/C cg07256473 chr22:29710276 RASL10A 0.39 5.57 0.32 6.1e-8 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs4588572 0.643 rs6453396 chr5:77785387 T/C cg11547950 chr5:77652471 NA -0.48 -6.09 -0.35 3.93e-9 Triglycerides; CESC cis rs2439831 0.867 rs6493082 chr15:43634808 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.31 0.6 7.84e-28 Lung cancer in ever smokers; CESC cis rs11645898 0.622 rs4788463 chr16:72223716 G/T cg14768367 chr16:72042858 DHODH -0.67 -5.04 -0.3 8.59e-7 Blood protein levels; CESC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg10691866 chr7:65817282 TPST1 -0.34 -5.65 -0.33 4.03e-8 Aortic root size; CESC cis rs9388451 0.839 rs10457469 chr6:126083658 G/A cg05901451 chr6:126070800 HEY2 -0.63 -8.86 -0.48 1.22e-16 Brugada syndrome; CESC cis rs11167764 1.000 rs3761757 chr5:141488219 A/C cg08523384 chr5:141488047 NDFIP1 -0.37 -5.43 -0.32 1.25e-7 Crohn's disease; CESC cis rs637571 0.522 rs503524 chr11:65751764 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.61 0.38 2.11e-10 Eosinophil percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03368399 chr8:22102556 POLR3D;MIR320A -0.38 -6.21 -0.36 1.99e-9 Gambling; CESC cis rs757110 0.834 rs1002226 chr11:17405617 C/T cg11839944 chr11:17409644 KCNJ11 0.39 5.38 0.31 1.66e-7 Type 2 diabetes; CESC cis rs9768139 0.524 rs7779175 chr7:158136918 C/T cg25566285 chr7:158114605 PTPRN2 -0.45 -6.23 -0.36 1.77e-9 Calcium levels; CESC cis rs637571 0.544 rs617791 chr11:65702523 C/G cg04055107 chr11:65626734 MUS81;CFL1 0.54 6.73 0.38 1.06e-10 Eosinophil percentage of white cells; CESC cis rs4969178 0.965 rs16971105 chr17:76393975 G/T cg20026190 chr17:76395443 PGS1 0.47 7.58 0.42 5.9e-13 HDL cholesterol levels; CESC cis rs713587 0.563 rs7591460 chr2:25103967 A/C cg01884057 chr2:25150051 NA 0.33 6.3 0.36 1.24e-9 Body mass index in non-asthmatics; CESC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg23283495 chr1:209979779 IRF6 0.46 5.66 0.33 3.89e-8 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06211794 chr20:48330587 B4GALT5 0.66 7.73 0.43 2.3e-13 Gut microbiome composition (summer); CESC cis rs12136530 0.681 rs6426798 chr1:19719728 C/T cg01832549 chr1:19774989 CAPZB -0.4 -5.74 -0.33 2.53e-8 Lead levels in blood; CESC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.77 9.64 0.51 4.76e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.17e-12 Tonsillectomy; CESC cis rs864745 0.579 rs849336 chr7:28224053 A/G cg23620719 chr7:28220237 JAZF1 -0.44 -5.2 -0.3 3.91e-7 Crohn's disease;Type 2 diabetes; CESC cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg17376030 chr22:41985996 PMM1 -0.73 -7.85 -0.43 1e-13 Vitiligo; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24340029 chr9:136039283 GBGT1 -0.35 -6.0 -0.35 6.34e-9 Gambling; CESC cis rs2235544 0.565 rs620907 chr1:54468166 T/G cg25741118 chr1:54482237 LDLRAD1 0.24 5.82 0.34 1.72e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs11608355 0.545 rs1073779 chr12:109894721 C/T cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs11190604 1.000 rs10509744 chr10:102271579 C/T cg07080220 chr10:102295463 HIF1AN 0.66 6.13 0.35 3.24e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs8017423 0.967 rs11844225 chr14:90726676 G/A cg14092571 chr14:90743983 NA -0.55 -8.29 -0.45 5.82e-15 Mortality in heart failure; CESC cis rs10949834 0.793 rs810532 chr7:73505188 A/G cg07137043 chr7:73588983 EIF4H -0.68 -7.39 -0.41 1.89e-12 Verbal memory performance (residualized delayed recall change); CESC cis rs4563143 0.514 rs73029081 chr19:29295583 C/G cg14983838 chr19:29218262 NA 0.5 5.52 0.32 8.22e-8 Methadone dose in opioid dependence; CESC cis rs6815814 0.950 rs67206233 chr4:38807853 T/C cg02016764 chr4:38805732 TLR1 -0.63 -7.26 -0.41 4.22e-12 Breast cancer; CESC cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg23158103 chr7:148848205 ZNF398 -0.41 -6.47 -0.37 4.71e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg07092213 chr7:1199455 ZFAND2A -0.46 -6.35 -0.36 9.42e-10 Longevity;Endometriosis; CESC cis rs4481887 1.000 rs4916124 chr1:248466495 T/C cg00666640 chr1:248458726 OR2T12 0.39 6.37 0.36 8.47e-10 Common traits (Other); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05007375 chr14:92588364 NDUFB1;CPSF2 -0.43 -6.26 -0.36 1.51e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4523957 0.579 rs903162 chr17:2092200 C/T cg16513277 chr17:2031491 SMG6 -0.61 -8.48 -0.46 1.59e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs3820068 0.608 rs7519899 chr1:16045579 A/G cg13390004 chr1:15929781 NA 0.34 5.21 0.3 3.79e-7 Systolic blood pressure; CESC cis rs6537837 0.838 rs71657105 chr1:110114122 G/A cg05049280 chr1:110155535 GNAT2 0.38 5.39 0.31 1.55e-7 Major depressive disorder; CESC trans rs3942852 0.606 rs10734561 chr11:48097480 C/T cg15704280 chr7:45808275 SEPT13 -0.61 -7.51 -0.42 8.79e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC cis rs6545883 1.000 rs778762 chr2:61782921 G/T cg15711740 chr2:61764176 XPO1 -0.42 -5.14 -0.3 5.46e-7 Tuberculosis; CESC cis rs6690583 0.623 rs893620 chr1:85425821 T/C cg22488158 chr1:85528044 WDR63 0.57 5.5 0.32 8.98e-8 Serum sulfate level; CESC cis rs727505 0.754 rs55859595 chr7:124783083 G/T cg23710748 chr7:124431027 NA -0.38 -6.2 -0.36 2.14e-9 Lewy body disease; CESC cis rs6674176 0.569 rs34830883 chr1:44405339 T/C cg13606994 chr1:44402422 ARTN -0.39 -6.06 -0.35 4.68e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7923609 1.000 rs1935 chr10:64927823 C/G cg01631684 chr10:65280961 REEP3 -0.46 -5.71 -0.33 3.06e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg05585544 chr11:47624801 NA -0.52 -7.82 -0.43 1.27e-13 Subjective well-being; CESC cis rs6540556 0.723 rs6679099 chr1:209895852 T/G cg05527609 chr1:210001259 C1orf107 -0.66 -7.32 -0.41 2.95e-12 Red blood cell count; CESC cis rs7267979 1.000 rs6115140 chr20:25285507 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 16.82 0.72 1.06e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg03433033 chr1:76189801 ACADM -0.8 -12.71 -0.62 3.18e-29 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9858542 0.953 rs9837341 chr3:49664767 A/G cg07274523 chr3:49395745 GPX1 0.68 8.7 0.47 3.66e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7666738 0.830 rs9996098 chr4:98867740 T/C cg17366294 chr4:99064904 C4orf37 0.54 7.48 0.42 1.1e-12 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.623 rs55724095 chr17:29153058 A/G cg13385521 chr17:29058706 SUZ12P 0.75 5.95 0.34 8.3e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7107174 1.000 rs2511171 chr11:77930935 G/A cg02023728 chr11:77925099 USP35 0.52 6.76 0.38 8.53e-11 Testicular germ cell tumor; CESC cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg04455712 chr21:45112962 RRP1B 0.39 5.76 0.33 2.31e-8 Mean corpuscular volume; CESC cis rs4450798 0.793 rs9855726 chr3:13741475 T/A cg23332027 chr3:13681764 NA 0.41 5.45 0.32 1.12e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7474896 0.609 rs11011336 chr10:37985316 A/G cg00409905 chr10:38381863 ZNF37A -0.47 -5.47 -0.32 1.06e-7 Obesity (extreme); CESC cis rs6088590 0.561 rs6088527 chr20:33155841 C/T cg24642439 chr20:33292090 TP53INP2 0.63 8.5 0.46 1.36e-15 Coronary artery disease; CESC cis rs6942756 1.000 rs6974155 chr7:128914545 C/G cg02491457 chr7:128862824 NA -0.7 -10.36 -0.54 2.47e-21 White matter hyperintensity burden; CESC cis rs478304 0.651 rs7110576 chr11:65512057 T/G cg10518572 chr11:65560635 OVOL1 -0.32 -6.53 -0.37 3.33e-10 Acne (severe); CESC cis rs2304069 0.954 rs2276983 chr5:149424966 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.84 10.86 0.55 5.76e-23 HIV-1 control; CESC cis rs360798 0.532 rs189671 chr2:62959308 T/A cg17519650 chr2:63277830 OTX1 -0.55 -6.94 -0.39 2.96e-11 Coronary artery disease; CESC cis rs752092 0.894 rs8043243 chr15:101771453 C/T cg19997662 chr15:101784653 CHSY1 -0.46 -5.98 -0.34 7.3e-9 Corneal structure; CESC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.34 -0.31 2.02e-7 Lung cancer; CESC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs4971059 0.654 rs4971078 chr1:155129023 A/G cg22049894 chr1:155113146 DPM3 0.47 6.07 0.35 4.4e-9 Breast cancer; CESC cis rs2286503 0.780 rs2240727 chr7:22852512 C/T cg13679077 chr7:22862647 TOMM7 0.52 6.58 0.37 2.57e-10 Fibrinogen; CESC cis rs6088580 0.634 rs6120666 chr20:33090718 A/G cg06115741 chr20:33292138 TP53INP2 0.45 5.8 0.34 1.9e-8 Glomerular filtration rate (creatinine); CESC cis rs9790314 0.628 rs1599381 chr3:160867680 G/A cg03342759 chr3:160939853 NMD3 -0.42 -5.86 -0.34 1.4e-8 Morning vs. evening chronotype; CESC cis rs7223966 0.655 rs6504165 chr17:61630076 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 5.66 0.33 3.92e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg14416269 chr4:6271139 WFS1 0.46 7.45 0.42 1.35e-12 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs28489187 0.617 rs233097 chr1:85825473 G/C cg16011679 chr1:85725395 C1orf52 0.45 5.31 0.31 2.35e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg12923728 chr3:195709715 SDHAP1 -0.67 -8.79 -0.48 1.88e-16 Pancreatic cancer; CESC cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg19539972 chr4:7069911 GRPEL1 -0.69 -6.88 -0.39 4.34e-11 Monocyte percentage of white cells; CESC cis rs61931739 0.500 rs11519123 chr12:34436478 A/G cg06521331 chr12:34319734 NA -0.37 -5.12 -0.3 5.98e-7 Morning vs. evening chronotype; CESC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg00933542 chr6:150070202 PCMT1 0.29 5.11 0.3 6.31e-7 Lung cancer; CESC cis rs7301826 0.560 rs12829294 chr12:131309972 A/G cg11011512 chr12:131303247 STX2 -0.45 -5.49 -0.32 9.37e-8 Plasma plasminogen activator levels; CESC cis rs12725198 1.000 rs12725198 chr1:16080171 A/G cg18133145 chr1:16060689 PLEKHM2 0.5 5.53 0.32 7.81e-8 Cardiac Troponin-T levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09828580 chr10:103868007 LDB1 0.45 6.44 0.37 5.53e-10 Fibrinogen levels; CESC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.29 0.41 3.54e-12 Height; CESC cis rs2073300 0.609 rs6137919 chr20:23363163 T/C cg16736954 chr20:23401023 NAPB 0.8 6.09 0.35 3.89e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs5769765 0.955 rs8135963 chr22:50301476 T/C cg26441486 chr22:50317300 CRELD2 0.4 5.38 0.31 1.6e-7 Schizophrenia; CESC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs1506636 1.000 rs652497 chr7:123423671 G/T cg03229431 chr7:123269106 ASB15 0.49 6.59 0.38 2.41e-10 Plateletcrit;Platelet count; CESC cis rs11122272 0.705 rs2572260 chr1:231486189 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.21 0.36 2.03e-9 Hemoglobin concentration; CESC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg04025307 chr7:1156635 C7orf50 -0.45 -6.94 -0.39 3.01e-11 Longevity;Endometriosis; CESC cis rs36051895 0.664 rs4593605 chr9:5107278 C/A cg02405213 chr9:5042618 JAK2 -0.49 -6.04 -0.35 5.3e-9 Pediatric autoimmune diseases; CESC cis rs1707322 0.789 rs10789473 chr1:46248131 C/T cg03146154 chr1:46216737 IPP 0.8 11.14 0.56 6.98e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs13064411 0.627 rs9872168 chr3:113233132 A/C cg18753928 chr3:113234510 CCDC52 -0.48 -5.72 -0.33 2.92e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg25934064 chr3:52569026 NT5DC2 0.25 5.25 0.31 3.08e-7 Electroencephalogram traits; CESC cis rs477692 0.699 rs509017 chr10:131367174 T/G cg24747557 chr10:131355152 MGMT -0.37 -5.1 -0.3 6.56e-7 Response to temozolomide; CESC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.43 0.32 1.27e-7 Bipolar disorder; CESC cis rs62064224 0.791 rs11653160 chr17:30717222 A/G cg25809561 chr17:30822961 MYO1D 0.59 8.31 0.45 4.87e-15 Schizophrenia; CESC cis rs9457247 0.510 rs6456151 chr6:167471851 A/C cg07741184 chr6:167504864 NA 0.36 6.21 0.36 2.01e-9 Crohn's disease; CESC cis rs9389248 0.500 rs116273677 chr6:135339135 A/C cg24558204 chr6:135376177 HBS1L 0.52 7.18 0.4 7.17e-12 High light scatter reticulocyte percentage of red cells; CESC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg27266027 chr21:40555129 PSMG1 0.48 5.73 0.33 2.74e-8 Cognitive function; CESC cis rs3749237 0.595 rs10865955 chr3:49499829 G/A cg06212747 chr3:49208901 KLHDC8B 0.49 6.6 0.38 2.26e-10 Resting heart rate; CESC cis rs3026101 0.624 rs60116755 chr17:5303215 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs9486715 0.867 rs4839842 chr6:96955387 A/T cg06623918 chr6:96969491 KIAA0776 0.93 14.38 0.66 4.75e-35 Headache; CESC cis rs67311347 1.000 rs28536038 chr3:40496382 A/C cg24209194 chr3:40518798 ZNF619 0.5 6.11 0.35 3.59e-9 Renal cell carcinoma; CESC cis rs854765 0.583 rs12603148 chr17:17865257 C/T cg16928487 chr17:17741425 SREBF1 -0.52 -8.66 -0.47 4.86e-16 Total body bone mineral density; CESC cis rs875971 0.651 rs313829 chr7:65552497 A/G cg05332525 chr7:65337924 VKORC1L1 -0.45 -5.18 -0.3 4.41e-7 Aortic root size; CESC cis rs7617773 0.817 rs3731534 chr3:48211777 C/T cg11946769 chr3:48343235 NME6 0.88 11.37 0.57 1.18e-24 Coronary artery disease; CESC cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg03676636 chr4:99064102 C4orf37 0.34 5.1 0.3 6.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2011503 0.943 rs2965195 chr19:19463032 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.51 -5.17 -0.3 4.66e-7 Bipolar disorder; CESC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg24829409 chr8:58192753 C8orf71 -0.5 -6.08 -0.35 4.13e-9 Developmental language disorder (linguistic errors); CESC cis rs4319547 0.656 rs4997380 chr12:122838956 A/G cg05707623 chr12:122985044 ZCCHC8 -0.45 -5.25 -0.31 3.06e-7 Body mass index; CESC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg25985355 chr7:65971099 NA 0.32 5.23 0.31 3.53e-7 Aortic root size; CESC cis rs7927771 1.000 rs12418852 chr11:47868853 C/G cg20307385 chr11:47447363 PSMC3 -0.49 -6.0 -0.35 6.54e-9 Subjective well-being; CESC cis rs9443645 0.775 rs9359359 chr6:79700980 T/C cg05283184 chr6:79620031 NA -0.38 -5.9 -0.34 1.13e-8 Intelligence (multi-trait analysis); CESC cis rs4472734 0.863 rs5028966 chr1:214618908 C/A cg00063699 chr1:214624242 PTPN14 -0.34 -5.28 -0.31 2.68e-7 Height; CESC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg18404041 chr3:52824283 ITIH1 -0.36 -5.97 -0.34 7.76e-9 Bipolar disorder; CESC cis rs9911578 1.000 rs2531732 chr17:56548420 T/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.52 -0.32 7.9e-8 Intelligence (multi-trait analysis); CESC cis rs2996428 0.643 rs6424056 chr1:3722486 G/A cg22529645 chr1:3704559 LRRC47 0.4 5.12 0.3 6.01e-7 Red cell distribution width; CESC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg17911788 chr17:44343683 NA -0.43 -6.79 -0.39 7.27e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2858942 0.575 rs2858011 chr16:247938 C/T cg00126636 chr16:237282 NA -0.45 -6.16 -0.35 2.75e-9 Mean corpuscular hemoglobin; CESC cis rs1153858 1.000 rs66714503 chr15:45648038 G/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.45e-9 Homoarginine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02239082 chr19:48972844 CYTH2 0.66 7.99 0.44 4.06e-14 Gut microbiome composition (summer); CESC cis rs7843479 1.000 rs1032094 chr8:21820479 A/T cg17168535 chr8:21777572 XPO7 0.49 6.73 0.38 1.03e-10 Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13483603 chr12:113344754 OAS1 0.43 6.12 0.35 3.41e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6089584 0.893 rs6089305 chr20:60571817 T/C cg13770153 chr20:60521292 NA -0.48 -6.37 -0.36 8.11e-10 Body mass index; CESC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg27165867 chr14:105738592 BRF1 -0.57 -6.06 -0.35 4.74e-9 Mean platelet volume;Platelet distribution width; CESC cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg25554036 chr4:6271136 WFS1 0.52 8.44 0.46 2.12e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6500395 1.000 rs4493038 chr16:48683920 A/G cg04672837 chr16:48644449 N4BP1 0.51 6.36 0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs11690935 0.655 rs12052995 chr2:172537212 A/G cg13550731 chr2:172543902 DYNC1I2 0.59 8.3 0.45 5.24e-15 Schizophrenia; CESC cis rs6580649 0.941 rs58046797 chr12:48487619 T/C cg24011408 chr12:48396354 COL2A1 -0.4 -5.04 -0.3 8.67e-7 Lung cancer; CESC cis rs2228479 0.850 rs11641147 chr16:89813589 C/T cg04013166 chr16:89971882 TCF25 0.79 6.78 0.38 7.83e-11 Skin colour saturation; CESC cis rs9733 0.744 rs4970976 chr1:150779524 T/A cg18016565 chr1:150552671 MCL1 -0.36 -5.93 -0.34 9.63e-9 Tonsillectomy; CESC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg22920501 chr2:26401640 FAM59B 0.8 9.08 0.49 2.61e-17 Gut microbiome composition (summer); CESC cis rs57083693 0.518 rs6538980 chr12:101692966 A/G cg22051763 chr12:101673672 UTP20 -0.44 -5.51 -0.32 8.71e-8 Alcohol dependence (age at onset); CESC cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg17366294 chr4:99064904 C4orf37 0.54 7.24 0.41 5.01e-12 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg23048001 chr7:2026167 MAD1L1 0.41 5.46 0.32 1.11e-7 Bipolar disorder and schizophrenia; CESC cis rs3857067 1.000 rs3857067 chr4:95026434 A/T cg11021082 chr4:95130006 SMARCAD1 -0.54 -8.29 -0.45 5.72e-15 QT interval; CESC cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg00701064 chr4:6280414 WFS1 0.66 10.99 0.56 2.16e-23 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2051211 0.895 rs2300670 chr3:38555815 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.62 -7.13 -0.4 9.69e-12 QRS duration; CESC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -5.75 -0.33 2.43e-8 Extrinsic epigenetic age acceleration; CESC cis rs2249625 0.545 rs2496487 chr6:72875226 G/C cg18830697 chr6:72922368 RIMS1 -0.48 -7.16 -0.4 7.86e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04405926 chr1:150208726 ANP32E 0.45 6.14 0.35 3.03e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2760061 0.626 rs2527614 chr1:228126470 A/G cg02753203 chr1:228287806 NA -0.5 -7.22 -0.41 5.54e-12 Diastolic blood pressure; CESC cis rs6662572 1.000 rs1053941 chr1:46084383 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.5 5.55 0.32 6.81e-8 Blood protein levels; CESC cis rs7582720 0.945 rs72936875 chr2:203791912 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs4888262 0.545 rs58136167 chr16:74700628 G/A cg01733217 chr16:74700730 RFWD3 0.9 12.8 0.62 1.6e-29 Testicular germ cell tumor; CESC trans rs2727020 0.554 rs7111711 chr11:49557880 G/A cg03929089 chr4:120376271 NA -0.7 -7.93 -0.44 6.31e-14 Coronary artery disease; CESC trans rs826838 0.654 rs7977738 chr12:38722460 G/A cg23762105 chr12:34175262 ALG10 -0.46 -6.03 -0.35 5.55e-9 Heart rate; CESC cis rs1568889 1.000 rs12797689 chr11:28076042 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.7 8.15 0.45 1.44e-14 Bipolar disorder; CESC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg07507251 chr3:52567010 NT5DC2 0.4 7.1 0.4 1.14e-11 Bipolar disorder; CESC cis rs3093024 0.935 rs10946216 chr6:167538897 T/C cg07741184 chr6:167504864 NA -0.33 -5.56 -0.32 6.49e-8 Rheumatoid arthritis; CESC cis rs2880765 0.545 rs17553734 chr15:86013059 C/G cg10818794 chr15:86012489 AKAP13 0.37 5.11 0.3 6.09e-7 Coronary artery disease; CESC cis rs727505 0.754 rs56056794 chr7:124783027 C/T cg23710748 chr7:124431027 NA -0.38 -6.2 -0.36 2.14e-9 Lewy body disease; CESC cis rs155076 1.000 rs2478824 chr13:21844144 G/C cg11317459 chr13:21872234 NA -1.01 -11.12 -0.56 7.88e-24 White matter hyperintensity burden; CESC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg14061069 chr19:46274453 DMPK 0.51 8.19 0.45 1.11e-14 Coronary artery disease; CESC cis rs4423214 1.000 rs732934 chr11:71186476 G/A cg05163923 chr11:71159392 DHCR7 0.8 10.68 0.55 2.29e-22 Vitamin D levels; CESC cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg03433033 chr1:76189801 ACADM 0.7 9.38 0.5 2.99e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.21 0.41 5.71e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg01341218 chr17:43662625 NA 0.92 11.18 0.57 5.1900000000000004e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3126085 0.877 rs868304 chr1:152178568 G/A cg26876637 chr1:152193138 HRNR 0.48 5.44 0.32 1.21e-7 Atopic dermatitis; CESC cis rs4253772 0.550 rs739164 chr22:46684558 C/T cg10231785 chr22:46692440 CN5H6.4;GTSE1 -0.61 -6.42 -0.37 6.38e-10 LDL cholesterol;Cholesterol, total; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25365794 chr17:8022404 ALOXE3 0.47 6.19 0.36 2.26e-9 Systemic lupus erythematosus; CESC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg19592336 chr6:28129416 ZNF389 0.61 8.24 0.45 8.13e-15 Depression; CESC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.67 0.38 1.47e-10 Bipolar disorder; CESC cis rs9584850 0.874 rs7988959 chr13:99104004 T/C cg22223119 chr13:99095684 FARP1 -0.38 -5.33 -0.31 2.06e-7 Neuroticism; CESC cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg06636001 chr8:8085503 FLJ10661 0.61 7.84 0.43 1.11e-13 Neuroticism; CESC cis rs35160687 0.623 rs2276625 chr2:86481835 A/G cg01119172 chr2:86362222 SNORD94;PTCD3 0.41 5.49 0.32 9.61e-8 Night sleep phenotypes; CESC cis rs2066819 1.000 rs41363748 chr12:56696056 C/T cg26714650 chr12:56694279 CS 1.5 10.42 0.54 1.53e-21 Psoriasis vulgaris; CESC cis rs909002 0.789 rs3817398 chr1:32119431 C/T cg13919466 chr1:32135498 COL16A1 0.44 7.95 0.44 5.54e-14 Intelligence (multi-trait analysis); CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg18538332 chr22:24372958 LOC391322 -0.76 -11.21 -0.57 4.11e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1506636 0.889 rs619075 chr7:123426317 A/T cg03229431 chr7:123269106 ASB15 0.5 6.65 0.38 1.71e-10 Plateletcrit;Platelet count; CESC cis rs910316 0.967 rs2024653 chr14:75595154 G/A cg11812906 chr14:75593930 NEK9 0.89 15.03 0.68 2.4e-37 Height; CESC cis rs568617 0.716 rs17854357 chr11:65601560 G/C cg04055107 chr11:65626734 MUS81;CFL1 1.0 8.35 0.46 3.71e-15 Crohn's disease; CESC cis rs782590 0.935 rs2627779 chr2:55892356 A/G cg18811423 chr2:55921094 PNPT1 0.79 12.54 0.61 1.25e-28 Metabolic syndrome; CESC cis rs3960554 0.599 rs56090527 chr7:75762125 A/C cg17325771 chr7:75508891 RHBDD2 -0.34 -5.23 -0.31 3.5e-7 Eotaxin levels; CESC cis rs295140 0.605 rs295149 chr2:201175244 A/G cg23649088 chr2:200775458 C2orf69 -0.43 -5.72 -0.33 2.9e-8 QT interval; CESC cis rs11098499 0.866 rs12513310 chr4:120288039 T/A cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs863345 0.604 rs10797020 chr1:158490324 A/G cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC cis rs13256369 0.802 rs2280560 chr8:8560602 C/T cg00074818 chr8:8560427 CLDN23 0.36 5.22 0.31 3.68e-7 Obesity-related traits; CESC cis rs7927771 0.965 rs35985502 chr11:47847428 G/A cg18512352 chr11:47633146 NA -0.6 -9.57 -0.51 8.16e-19 Subjective well-being; CESC trans rs1814175 0.676 rs11040647 chr11:49935947 A/C cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs9899728 0.764 rs9660 chr17:73038746 A/G cg27626185 chr17:73056755 KCTD2 -0.56 -5.64 -0.33 4.28e-8 Alzheimer's disease or small vessel stroke; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08477215 chr7:75072259 POM121C -0.62 -7.53 -0.42 8.09e-13 Gut microbiome composition (summer); CESC cis rs1045902 0.967 rs10207625 chr2:73464808 T/C cg01422370 chr2:73384389 NA 0.43 7.29 0.41 3.57e-12 Intelligence (multi-trait analysis); CESC trans rs9325144 0.602 rs10785590 chr12:38694145 C/T cg23762105 chr12:34175262 ALG10 -0.49 -6.56 -0.37 2.76e-10 Morning vs. evening chronotype; CESC cis rs909002 0.849 rs2271933 chr1:32092525 C/T cg13919466 chr1:32135498 COL16A1 0.46 8.21 0.45 9.83e-15 Intelligence (multi-trait analysis); CESC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg11494091 chr17:61959527 GH2 0.76 13.29 0.63 3.18e-31 Prudent dietary pattern; CESC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg09781414 chr16:715207 WDR90 -0.35 -5.34 -0.31 1.95e-7 Height; CESC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg09177884 chr7:1199841 ZFAND2A -0.52 -6.74 -0.38 9.71e-11 Longevity;Endometriosis; CESC cis rs9790314 1.000 rs189270 chr3:161063504 T/C cg03342759 chr3:160939853 NMD3 -0.5 -6.54 -0.37 3.13e-10 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09770068 chr12:52294251 NA -0.55 -6.8 -0.39 7.12e-11 Gut microbiome composition (summer); CESC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg24768116 chr2:27665128 KRTCAP3 -0.31 -5.96 -0.34 8.08e-9 Total body bone mineral density; CESC cis rs477692 0.544 rs12251589 chr10:131417354 C/A cg24747557 chr10:131355152 MGMT 0.43 5.93 0.34 9.25e-9 Response to temozolomide; CESC cis rs10870270 1.000 rs7077744 chr10:133770201 C/T cg26149184 chr10:133730230 NA 0.38 5.14 0.3 5.22e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.57 0.37 2.63e-10 Bipolar disorder; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg27094323 chr7:1216898 NA -0.43 -6.03 -0.35 5.61e-9 Longevity;Endometriosis; CESC cis rs1008375 1.000 rs3733579 chr4:17694943 A/G cg16339924 chr4:17578868 LAP3 0.57 7.11 0.4 1.06e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11098499 0.863 rs3775854 chr4:120471971 C/T cg24375607 chr4:120327624 NA 0.45 5.5 0.32 9.09e-8 Corneal astigmatism; CESC cis rs7826238 0.502 rs10503377 chr8:8378422 C/T cg15556689 chr8:8085844 FLJ10661 0.45 5.5 0.32 8.8e-8 Systolic blood pressure; CESC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg09509183 chr1:209979624 IRF6 0.51 6.42 0.37 6.24e-10 Cleft lip with or without cleft palate; CESC cis rs61996546 0.622 rs56031087 chr15:26847834 A/C cg15066197 chr15:26874202 GABRB3 -0.35 -5.19 -0.3 4.1e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs9815354 0.812 rs17283243 chr3:41914792 C/T cg03022575 chr3:42003672 ULK4 0.7 6.18 0.36 2.38e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg21770322 chr7:97807741 LMTK2 0.55 8.1 0.45 2.02e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.48 0.42 1.1e-12 Tonsillectomy; CESC cis rs7124681 0.546 rs7941399 chr11:47890421 A/T cg20307385 chr11:47447363 PSMC3 0.63 8.82 0.48 1.52e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs17023223 0.537 rs4590715 chr1:119750201 C/T cg05756136 chr1:119680316 WARS2 -0.48 -5.79 -0.33 2.03e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs4689388 0.824 rs6446482 chr4:6295693 C/G cg14416269 chr4:6271139 WFS1 0.46 7.71 0.43 2.6e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2370759 0.898 rs113412621 chr10:32579306 C/T cg01819863 chr10:32635814 EPC1 1.16 13.25 0.63 4.48e-31 Sexual dysfunction (female); CESC cis rs1005277 0.540 rs7903942 chr10:37929276 C/T cg25427524 chr10:38739819 LOC399744 0.62 8.98 0.48 5.15e-17 Extrinsic epigenetic age acceleration; CESC cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs10851478 0.842 rs34146550 chr15:49790877 T/C cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs9611519 0.780 rs2235849 chr22:41653540 T/G cg03806693 chr22:41940476 POLR3H -0.56 -6.56 -0.37 2.75e-10 Neuroticism; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg15717258 chr5:140537705 PCDHB17 -0.47 -6.64 -0.38 1.78e-10 Psoriatic arthritis; CESC cis rs4654899 1.000 rs6426660 chr1:21361640 A/G cg05370193 chr1:21551575 ECE1 0.39 5.85 0.34 1.47e-8 Superior frontal gyrus grey matter volume; CESC cis rs7296418 0.961 rs4148863 chr12:123569375 A/G cg00376283 chr12:123451042 ABCB9 0.74 10.75 0.55 1.3e-22 Platelet count; CESC cis rs1832871 0.683 rs9459852 chr6:158687250 T/G cg07165851 chr6:158734300 TULP4 0.59 6.23 0.36 1.87e-9 Height; CESC cis rs1055129 0.560 rs2608880 chr17:73938957 C/T cg08125733 chr17:73851984 WBP2 0.5 6.74 0.38 9.73e-11 White matter hyperintensity burden; CESC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg08027265 chr7:2291960 NA -0.36 -5.48 -0.32 1.01e-7 Bipolar disorder and schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16866257 chr17:61905183 FTSJ3;PSMC5 0.49 6.2 0.36 2.18e-9 Gut microbiota (bacterial taxa); CESC cis rs28830936 0.510 rs7174099 chr15:42099059 A/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.32 -5.05 -0.3 8.06e-7 Diastolic blood pressure; CESC cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.56 6.89 0.39 4.14e-11 Tonsillectomy; CESC cis rs17666538 0.636 rs10107345 chr8:603700 G/T cg07234876 chr8:600039 NA 0.79 6.63 0.38 1.83e-10 IgG glycosylation; CESC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg24250549 chr1:154909240 PMVK -0.76 -11.29 -0.57 2.19e-24 Prostate cancer; CESC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg06481639 chr22:41940642 POLR3H -0.56 -6.14 -0.35 2.93e-9 Vitiligo; CESC cis rs2075371 0.611 rs35428392 chr7:134019645 G/A cg20476274 chr7:133979776 SLC35B4 0.55 7.38 0.41 2.01e-12 Mean platelet volume; CESC cis rs7592578 0.771 rs4258824 chr2:191395027 C/T cg10560079 chr2:191398806 TMEM194B -0.55 -5.04 -0.3 8.66e-7 Diastolic blood pressure; CESC cis rs10504229 0.817 rs55891651 chr8:58167600 C/T cg05313129 chr8:58192883 C8orf71 -0.46 -5.85 -0.34 1.46e-8 Developmental language disorder (linguistic errors); CESC cis rs9790314 0.521 rs13084746 chr3:161086038 G/A cg03342759 chr3:160939853 NMD3 -0.41 -5.74 -0.33 2.52e-8 Morning vs. evening chronotype; CESC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg06108461 chr20:60628389 TAF4 -0.81 -11.72 -0.58 7.56e-26 Body mass index; CESC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg25072359 chr17:41440525 NA 0.46 6.12 0.35 3.4e-9 Menopause (age at onset); CESC cis rs2282802 0.635 rs397463 chr5:139584275 C/G cg26211634 chr5:139558579 C5orf32 -0.5 -7.41 -0.41 1.68e-12 Intelligence (multi-trait analysis); CESC cis rs4253772 0.591 rs11703848 chr22:46685131 A/G cg24881330 chr22:46731750 TRMU 0.75 5.43 0.32 1.25e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2635047 0.512 rs9962436 chr18:44599109 A/G cg19077165 chr18:44547161 KATNAL2 -0.42 -5.91 -0.34 1.07e-8 Educational attainment; CESC cis rs141759085 1 rs141759085 chr16:530967 A/G cg00676925 chr16:540266 RAB11FIP3 -0.65 -7.38 -0.41 2.03e-12 Platelet count; CESC cis rs143000161 1 rs143000161 chr2:165710540 A/T cg03182029 chr2:165697222 COBLL1 0.72 5.64 0.33 4.36e-8 Heschl's gyrus morphology; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04135372 chr2:99061383 INPP4A 0.46 6.46 0.37 4.89e-10 Gut microbiota (bacterial taxa); CESC cis rs9863 0.861 rs7958691 chr12:124440743 G/T cg17562584 chr12:124393655 DNAH10 0.32 5.56 0.32 6.59e-8 White blood cell count; CESC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg17949981 chr6:28129498 ZNF389 0.44 5.53 0.32 7.84e-8 Depression; CESC trans rs6934970 0.860 rs4354190 chr6:112981624 T/C cg05146922 chr2:10634174 NA -0.36 -6.01 -0.35 5.97e-9 Bipolar disorder (body mass index interaction); CESC cis rs6087990 0.584 rs6058897 chr20:31398105 G/T cg13636640 chr20:31349939 DNMT3B -0.73 -11.61 -0.58 1.86e-25 Ulcerative colitis; CESC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.09 -0.35 3.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7555523 0.779 rs6662839 chr1:165722646 T/G cg24409356 chr1:165738333 TMCO1 0.97 8.67 0.47 4.48e-16 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs9715521 0.900 rs72634620 chr4:59822396 C/T cg11281224 chr4:60001000 NA -0.51 -6.67 -0.38 1.45e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7772486 0.686 rs1337841 chr6:146059487 A/G cg23711669 chr6:146136114 FBXO30 -0.89 -13.12 -0.63 1.2e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs8017423 0.647 rs12882575 chr14:90820454 C/G cg14092571 chr14:90743983 NA 0.43 6.55 0.37 2.91e-10 Mortality in heart failure; CESC cis rs6540559 0.673 rs114467813 chr1:210017785 G/A cg21951975 chr1:209979733 IRF6 0.6 6.65 0.38 1.63e-10 Cleft lip with or without cleft palate; CESC cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg02551604 chr5:131831745 NA -0.37 -5.27 -0.31 2.81e-7 Asthma (sex interaction); CESC cis rs72792276 1.000 rs56657382 chr5:127387338 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.68 5.24 0.31 3.26e-7 Red cell distribution width; CESC cis rs11958404 0.932 rs72816543 chr5:157416464 A/G cg05962755 chr5:157440814 NA 0.62 6.64 0.38 1.74e-10 IgG glycosylation; CESC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg20243544 chr17:37824526 PNMT -0.46 -5.66 -0.33 3.97e-8 Glomerular filtration rate (creatinine); CESC cis rs2404602 0.598 rs11855999 chr15:76627333 A/C cg06336613 chr15:77223807 RCN2 0.41 5.09 0.3 6.72e-7 Blood metabolite levels; CESC cis rs225245 0.782 rs321599 chr17:33905745 C/T cg05299278 chr17:33885742 SLFN14 0.38 5.46 0.32 1.08e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs116095464 0.558 rs2288458 chr5:231260 C/T cg22857025 chr5:266934 NA -1.28 -18.2 -0.75 1.47e-48 Breast cancer; CESC cis rs4423214 0.592 rs10898234 chr11:71236684 A/G cg05163923 chr11:71159392 DHCR7 -0.55 -5.89 -0.34 1.17e-8 Vitamin D levels; CESC cis rs6089584 0.586 rs4925216 chr20:60599923 G/A cg06108461 chr20:60628389 TAF4 -0.58 -7.7 -0.43 2.68e-13 Body mass index; CESC cis rs4919694 1.000 rs112809537 chr10:104670346 C/T cg04362960 chr10:104952993 NT5C2 0.78 6.58 0.37 2.5e-10 Arsenic metabolism; CESC trans rs1814175 0.817 rs10839318 chr11:49657511 G/C cg15704280 chr7:45808275 SEPT13 -1.04 -20.31 -0.78 6.22e-56 Height; CESC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg03351412 chr1:154909251 PMVK 0.7 9.54 0.51 9.98e-19 Prostate cancer; CESC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg00277769 chr7:97922759 BAIAP2L1 0.32 5.34 0.31 2.05e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs2797160 1.000 rs1777183 chr6:126011995 A/C cg05901451 chr6:126070800 HEY2 0.46 6.55 0.37 2.91e-10 Endometrial cancer; CESC cis rs7267979 1.000 rs397119 chr20:25440187 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.9 0.7 1.91e-40 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09019002 chr7:102715232 ARMC10;FBXL13 0.62 7.68 0.43 3.18e-13 Gut microbiome composition (summer); CESC trans rs17685 0.558 rs60787921 chr7:75792844 C/A cg19862616 chr7:65841803 NCRNA00174 0.84 12.03 0.59 6.77e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.54 -0.37 3.21e-10 Life satisfaction; CESC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -7.04 -0.4 1.69e-11 Extrinsic epigenetic age acceleration; CESC cis rs9911578 1.000 rs999431 chr17:56854441 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.2 0.68 6.06e-38 Intelligence (multi-trait analysis); CESC cis rs10465746 0.725 rs1359331 chr1:84360301 C/A cg10977910 chr1:84465055 TTLL7 0.56 7.74 0.43 2.07e-13 Obesity-related traits; CESC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg24642844 chr7:1081250 C7orf50 -0.75 -9.03 -0.49 3.61e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4474465 0.850 rs4387376 chr11:78257662 T/C cg27205649 chr11:78285834 NARS2 0.42 5.4 0.31 1.49e-7 Alzheimer's disease (survival time); CESC cis rs3015497 0.603 rs1494178 chr14:51072210 A/C cg26011998 chr14:51135199 SAV1 -0.46 -5.22 -0.31 3.6e-7 Mean platelet volume; CESC cis rs854765 0.583 rs7503334 chr17:17779458 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.52 -7.21 -0.41 5.78e-12 Total body bone mineral density; CESC cis rs10870270 1.000 rs11146354 chr10:133774757 A/G cg17892150 chr10:133769511 PPP2R2D -0.86 -12.56 -0.61 1.08e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg09365446 chr1:150670422 GOLPH3L 0.4 5.45 0.32 1.14e-7 Melanoma; CESC cis rs4423214 0.840 rs1123007 chr11:71185357 G/A cg05163923 chr11:71159392 DHCR7 -0.7 -7.97 -0.44 4.79e-14 Vitamin D levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04371633 chr14:65381025 CHURC1 -0.46 -6.34 -0.36 9.89e-10 Height; CESC cis rs4689388 0.750 rs10001190 chr4:6284633 C/T cg25554036 chr4:6271136 WFS1 -0.49 -7.36 -0.41 2.25e-12 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9467773 0.587 rs9467722 chr6:26352566 T/C cg14345882 chr6:26364793 BTN3A2 0.29 5.06 0.3 7.96e-7 Intelligence (multi-trait analysis); CESC cis rs870825 0.616 rs4437299 chr4:185643223 T/A cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs854765 0.547 rs28537385 chr17:17902135 G/A cg04398451 chr17:18023971 MYO15A -0.71 -10.42 -0.54 1.54e-21 Total body bone mineral density; CESC cis rs7592578 0.679 rs62181020 chr2:191325601 A/C cg27211696 chr2:191398769 TMEM194B -0.59 -5.9 -0.34 1.13e-8 Diastolic blood pressure; CESC cis rs6714710 0.603 rs11692010 chr2:98397301 C/T cg26665480 chr2:98280029 ACTR1B 0.56 7.87 0.44 8.84e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs2262909 0.925 rs73019900 chr19:22286680 G/A cg11619707 chr19:22235551 ZNF257 0.34 5.58 0.32 6.06e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs13191362 0.935 rs7767254 chr6:162954674 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.79 7.79 0.43 1.52e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs9287719 0.578 rs13425171 chr2:10731966 C/G cg00105475 chr2:10696890 NA 0.39 5.27 0.31 2.83e-7 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05645997 chr2:108443466 LOC729121;RGPD4 0.53 7.38 0.41 2.08e-12 Fibrinogen levels; CESC cis rs8002861 0.727 rs9525850 chr13:44402100 C/T cg19180546 chr13:44453867 C13orf31;CCDC122 -0.4 -5.13 -0.3 5.7e-7 Leprosy; CESC cis rs2299587 0.554 rs2073565 chr8:17743649 T/C cg08627089 chr8:17753878 FGL1 -0.4 -5.76 -0.33 2.37e-8 Economic and political preferences; CESC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg01341218 chr17:43662625 NA 0.56 7.5 0.42 9.66e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs709400 0.859 rs942863 chr14:104021268 C/T cg12935359 chr14:103987150 CKB -0.49 -6.3 -0.36 1.21e-9 Body mass index; CESC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg23462726 chr11:62437636 C11orf83;C11orf48 -0.44 -5.87 -0.34 1.33e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs8072100 0.666 rs9913014 chr17:45460189 C/T cg25173405 chr17:45401733 C17orf57 -0.43 -5.42 -0.32 1.36e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg08859206 chr1:53392774 SCP2 0.53 7.09 0.4 1.19e-11 Monocyte count; CESC cis rs703842 1.000 rs3825079 chr12:58203354 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.71 9.12 0.49 1.96e-17 Multiple sclerosis; CESC cis rs5753618 0.539 rs2228619 chr22:31663842 C/G cg00478049 chr22:31556069 RNF185 0.45 5.16 0.3 4.89e-7 Colorectal cancer; CESC cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg18252515 chr7:66147081 NA -0.56 -5.61 -0.33 5.16e-8 Diabetic kidney disease; CESC cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg15369054 chr17:80825471 TBCD 0.37 5.28 0.31 2.69e-7 Breast cancer; CESC cis rs2795502 1.000 rs2744090 chr10:43339614 G/C cg27426351 chr10:43362370 NA -0.45 -5.5 -0.32 8.91e-8 Blood protein levels; CESC cis rs7107174 0.892 rs2512548 chr11:77962116 A/G cg02023728 chr11:77925099 USP35 0.45 6.36 0.36 8.61e-10 Testicular germ cell tumor; CESC cis rs2115536 0.935 rs11854390 chr15:80224817 C/T cg11839771 chr15:80205821 ST20 -0.35 -5.09 -0.3 6.8e-7 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs9486719 1.000 rs12201449 chr6:96959382 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -8.21 -0.45 9.67e-15 Migraine;Coronary artery disease; CESC cis rs1707322 1.000 rs11211200 chr1:46288352 A/G cg06784218 chr1:46089804 CCDC17 0.31 5.34 0.31 2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2073300 0.609 rs6137931 chr20:23376875 G/C cg12062639 chr20:23401060 NAPB 1.07 8.85 0.48 1.29e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2075371 0.674 rs11771785 chr7:134013249 A/G cg11752832 chr7:134001865 SLC35B4 -0.43 -5.05 -0.3 8.14e-7 Mean platelet volume; CESC cis rs832540 0.519 rs10036895 chr5:56273693 G/A cg12311346 chr5:56204834 C5orf35 -0.44 -5.44 -0.32 1.19e-7 Coronary artery disease; CESC cis rs1707322 1.000 rs4134387 chr1:46395158 A/T cg05343316 chr1:45956843 TESK2 0.5 6.13 0.35 3.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9876781 0.530 rs11708617 chr3:48396309 C/T cg11946769 chr3:48343235 NME6 0.4 5.25 0.31 3.13e-7 Longevity; CESC cis rs12477438 0.520 rs13035311 chr2:99717322 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 15.55 0.69 3.41e-39 Chronic sinus infection; CESC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg03467027 chr4:99064603 C4orf37 0.48 6.06 0.35 4.54e-9 Colonoscopy-negative controls vs population controls; CESC cis rs754466 0.606 rs11002315 chr10:79617385 T/G cg17075019 chr10:79541650 NA -0.87 -13.72 -0.64 1.01e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7927771 1.000 rs12419692 chr11:47624714 A/C cg05585544 chr11:47624801 NA 0.49 7.64 0.42 4.01e-13 Subjective well-being; CESC cis rs8067354 0.574 rs1292050 chr17:57965169 T/C cg02344993 chr17:57696989 CLTC 0.53 5.56 0.32 6.43e-8 Hemoglobin concentration; CESC cis rs3026101 0.624 rs62072673 chr17:5317669 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.12 0.3 5.75e-7 Body mass index; CESC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg14061069 chr19:46274453 DMPK 0.51 8.12 0.45 1.76e-14 Coronary artery disease; CESC cis rs733175 0.855 rs6853437 chr4:10005435 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -5.2 -0.3 3.91e-7 Psychosis and Alzheimer's disease; CESC cis rs7259376 0.905 rs116632927 chr19:22562520 C/T cg02657401 chr19:22469223 NA -0.26 -5.18 -0.3 4.47e-7 Menopause (age at onset); CESC cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.29 0.45 5.87e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.73 -11.55 -0.58 2.97e-25 Personality dimensions; CESC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg08736216 chr1:53307985 ZYG11A 0.35 6.17 0.35 2.52e-9 Monocyte count; CESC cis rs96067 0.711 rs272827 chr1:36627191 C/T cg24686825 chr1:36642396 MAP7D1 0.64 8.2 0.45 1.05e-14 Corneal structure; CESC cis rs4604732 0.631 rs7546720 chr1:247627229 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs28489187 0.706 rs18582 chr1:85794819 A/G cg16011679 chr1:85725395 C1orf52 0.48 5.83 0.34 1.62e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs412050 1.000 rs239919 chr22:22313128 C/T cg17089214 chr22:22089827 YPEL1 0.64 5.93 0.34 9.33e-9 Attention deficit hyperactivity disorder; CESC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs826838 1.000 rs7299124 chr12:39002661 T/C cg26384229 chr12:38710491 ALG10B 0.82 14.29 0.66 1.01e-34 Heart rate; CESC cis rs7917772 0.604 rs7908249 chr10:104373300 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.39 5.41 0.32 1.43e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg19622623 chr12:86230825 RASSF9 -0.47 -6.05 -0.35 5.05e-9 Major depressive disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05214047 chr5:56112645 MAP3K1 -0.44 -6.42 -0.37 6.11e-10 Gambling; CESC cis rs7937682 0.889 rs479667 chr11:111484034 C/T cg22437258 chr11:111473054 SIK2 0.71 9.61 0.51 6.16e-19 Primary sclerosing cholangitis; CESC cis rs2979489 0.891 rs17551512 chr8:30330109 A/G cg26383811 chr8:30366931 RBPMS -0.83 -9.92 -0.52 6.32e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC cis rs950169 0.810 rs62029594 chr15:84955252 T/C cg17507749 chr15:85114479 UBE2QP1 0.59 6.54 0.37 3.11e-10 Schizophrenia; CESC cis rs6714710 0.603 rs11679828 chr2:98517626 G/A cg26665480 chr2:98280029 ACTR1B 0.6 8.14 0.45 1.57e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg21395723 chr22:39101663 GTPBP1 0.43 5.29 0.31 2.55e-7 Menopause (age at onset); CESC cis rs72781680 1.000 rs17711825 chr2:24124578 A/G cg20701182 chr2:24300061 SF3B14 0.62 5.58 0.32 5.85e-8 Lymphocyte counts; CESC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg05255149 chr17:80675120 FN3KRP -0.45 -5.23 -0.31 3.49e-7 Breast cancer; CESC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.94 0.59 1.43e-26 Alzheimer's disease; CESC cis rs2072732 0.756 rs7514166 chr1:2949607 G/C cg15211996 chr1:2936768 ACTRT2 0.35 6.12 0.35 3.42e-9 Plateletcrit; CESC cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 1.000 rs4752797 chr11:47874364 C/T cg05585544 chr11:47624801 NA -0.45 -6.93 -0.39 3.15e-11 Subjective well-being; CESC cis rs2932538 0.922 rs6537744 chr1:113096746 C/G cg22162597 chr1:113214053 CAPZA1 0.56 7.02 0.4 1.82e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs75477785 0.590 rs4844501 chr1:210104598 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.94 6.89 0.39 4.04e-11 Cleft lip with or without cleft palate; CESC cis rs921968 0.541 rs588770 chr2:219494638 T/C cg02176678 chr2:219576539 TTLL4 0.43 7.47 0.42 1.14e-12 Mean corpuscular hemoglobin concentration; CESC cis rs11098499 0.954 rs17006190 chr4:120418838 C/G cg09307838 chr4:120376055 NA 0.92 12.86 0.62 9.72e-30 Corneal astigmatism; CESC cis rs2764980 1.000 rs2764980 chr10:3284007 C/T cg11630169 chr10:3283847 NA 0.37 5.24 0.31 3.21e-7 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs6430585 0.591 rs309118 chr2:136746224 G/C cg07169764 chr2:136633963 MCM6 1.12 16.81 0.72 1.2e-43 Corneal structure; CESC cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg04546413 chr19:29218101 NA 0.56 7.91 0.44 6.84e-14 Methadone dose in opioid dependence; CESC cis rs7100689 0.784 rs10749562 chr10:82108253 G/T cg09936400 chr10:82049201 MAT1A 0.37 5.28 0.31 2.73e-7 Post bronchodilator FEV1; CESC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg08888203 chr3:10149979 C3orf24 0.48 6.08 0.35 4.18e-9 Alzheimer's disease; CESC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg06582575 chr6:163149167 PACRG;PARK2 1.02 10.2 0.53 7.92e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12393716 chr11:62495049 TTC9C;HNRNPUL2 0.52 7.2 0.4 6.18e-12 Systemic lupus erythematosus; CESC cis rs863345 0.967 rs1342944 chr1:158512923 T/C cg12129480 chr1:158549410 OR10X1 -0.32 -6.48 -0.37 4.53e-10 Pneumococcal bacteremia; CESC cis rs6547741 0.935 rs12714204 chr2:27787540 T/C cg27432699 chr2:27873401 GPN1 0.48 6.84 0.39 5.6e-11 Oral cavity cancer; CESC cis rs6815814 0.768 rs2013740 chr4:38891737 A/G cg02016764 chr4:38805732 TLR1 -0.51 -6.97 -0.39 2.55e-11 Breast cancer; CESC cis rs9457247 0.555 rs2247325 chr6:167369992 A/G cg23791538 chr6:167370224 RNASET2 0.66 9.47 0.5 1.64e-18 Crohn's disease; CESC cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.5 0.46 1.41e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11098499 0.754 rs10518300 chr4:120249499 G/T cg25214090 chr10:38739885 LOC399744 -0.59 -8.03 -0.44 3.2e-14 Corneal astigmatism; CESC cis rs1847202 0.826 rs1979884 chr3:72948515 T/C cg25664220 chr3:72788482 NA -0.37 -5.49 -0.32 9.43e-8 Motion sickness; CESC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg20891558 chr2:74357851 NA 0.82 10.24 0.53 5.88e-21 Gestational age at birth (maternal effect); CESC cis rs34779708 0.931 rs7923217 chr10:35309589 A/G cg03585969 chr10:35415529 CREM 0.76 10.11 0.53 1.57e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs9902453 0.740 rs2244247 chr17:28110174 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs11638352 0.661 rs2706488 chr15:44389897 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.66 -0.33 3.84e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs727563 0.593 rs132770 chr22:42017264 A/G cg06634786 chr22:41940651 POLR3H 0.61 5.99 0.35 6.94e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.49 -6.19 -0.36 2.31e-9 Prudent dietary pattern; CESC cis rs2404602 0.662 rs908817 chr15:76639191 G/A cg23625390 chr15:77176239 SCAPER -0.44 -5.99 -0.35 6.98e-9 Blood metabolite levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09444120 chr8:107227878 NA -0.44 -6.11 -0.35 3.53e-9 Asthma; CESC cis rs250677 0.687 rs2963484 chr5:148451127 A/T cg18129178 chr5:148520854 ABLIM3 -0.51 -5.84 -0.34 1.54e-8 Breast cancer; CESC cis rs6087990 0.965 rs2424904 chr20:31352316 T/C cg13636640 chr20:31349939 DNMT3B 0.92 16.25 0.71 1.16e-41 Ulcerative colitis; CESC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg09060608 chr5:178986726 RUFY1 0.56 8.69 0.47 3.87e-16 Lung cancer; CESC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.81 0.39 6.56e-11 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09719331 chr20:44486197 ZSWIM3;ACOT8 -0.5 -6.13 -0.35 3.17e-9 Gut microbiome composition (summer); CESC cis rs1580019 0.563 rs34201720 chr7:32568935 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.61 0.38 2.16e-10 Cognitive ability; CESC cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.61 7.3 0.41 3.27e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs853679 0.505 rs200992 chr6:27814677 A/G cg06606381 chr12:133084897 FBRSL1 -0.86 -7.85 -0.43 1.03e-13 Depression; CESC cis rs2295499 0.754 rs3864117 chr4:2626569 G/A cg27239842 chr4:2403781 ZFYVE28 -0.34 -5.65 -0.33 4.05e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs6912958 0.712 rs4707383 chr6:88330602 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.74 -0.38 1.01e-10 Monocyte percentage of white cells; CESC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg26314531 chr2:26401878 FAM59B -0.6 -6.79 -0.38 7.45e-11 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg04414720 chr1:150670196 GOLPH3L 0.63 9.04 0.49 3.47e-17 Tonsillectomy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03413328 chr12:8851234 RIMKLB 0.46 6.18 0.35 2.36e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs5753618 0.504 rs5753659 chr22:31893613 A/G cg02404636 chr22:31891804 SFI1 0.41 5.21 0.31 3.73e-7 Colorectal cancer; CESC cis rs3020736 0.500 rs6002623 chr22:42513761 G/A cg04733989 chr22:42467013 NAGA -0.78 -11.9 -0.59 1.87e-26 Autism spectrum disorder or schizophrenia; CESC cis rs7193541 0.684 rs4887783 chr16:74700743 G/C cg01733217 chr16:74700730 RFWD3 1.09 22.56 0.81 1.32e-63 Multiple myeloma; CESC cis rs6714710 0.627 rs11680883 chr2:98472610 T/C cg26665480 chr2:98280029 ACTR1B 0.68 9.13 0.49 1.75e-17 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs17376456 0.778 rs10440717 chr5:93424852 C/A cg25358565 chr5:93447407 FAM172A 1.14 11.74 0.58 6.72e-26 Diabetic retinopathy; CESC cis rs1788820 0.917 rs1788826 chr18:21154024 G/A cg14672496 chr18:21087552 C18orf8 0.54 7.36 0.41 2.32e-12 Body mass index; CESC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg14829155 chr15:31115871 NA -0.73 -9.8 -0.52 1.51e-19 Huntington's disease progression; CESC cis rs7666738 0.830 rs1869082 chr4:98841254 T/A cg17366294 chr4:99064904 C4orf37 0.52 7.14 0.4 9e-12 Colonoscopy-negative controls vs population controls; CESC cis rs4595586 0.655 rs7953715 chr12:39325539 T/C cg26384229 chr12:38710491 ALG10B 0.41 5.93 0.34 9.53e-9 Morning vs. evening chronotype; CESC cis rs2055729 0.507 rs814424 chr8:9942924 C/T cg21625330 chr8:9911636 MSRA 0.5 5.77 0.33 2.26e-8 Multiple myeloma (hyperdiploidy); CESC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg11890956 chr21:40555474 PSMG1 1.18 22.82 0.81 1.7600000000000002e-64 Cognitive function; CESC cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 5.86e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 1.000 rs1796220 chr7:66062100 C/T cg12463550 chr7:65579703 CRCP 0.74 5.83 0.34 1.61e-8 Diabetic kidney disease; CESC cis rs7666738 0.791 rs2081622 chr4:98927369 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7917772 0.503 rs7093285 chr10:104374815 G/C ch.10.2196322F chr10:104248062 ACTR1A 0.46 5.38 0.31 1.66e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs3796352 1.000 rs35174175 chr3:53041509 T/C cg12962167 chr3:53033115 SFMBT1 0.65 5.17 0.3 4.52e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg08470875 chr2:26401718 FAM59B -0.73 -7.96 -0.44 4.94e-14 Gut microbiome composition (summer); CESC cis rs12545109 0.765 rs2576594 chr8:57412126 T/G cg09654669 chr8:57350985 NA -0.53 -6.23 -0.36 1.84e-9 Obesity-related traits; CESC cis rs3768617 0.510 rs7549768 chr1:183097382 T/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.27 0.66 1.13e-34 Fuchs's corneal dystrophy; CESC cis rs2276314 0.857 rs7237599 chr18:33639396 T/C cg05985134 chr18:33552581 C18orf21 0.62 7.54 0.42 7.57e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs11249608 0.789 rs1969025 chr5:178425192 A/G cg21905437 chr5:178450457 ZNF879 0.53 7.11 0.4 1.11e-11 Pubertal anthropometrics; CESC cis rs9595066 0.627 rs4942290 chr13:44757339 C/T cg04068111 chr13:44716778 NA -0.44 -5.59 -0.32 5.7e-8 Schizophrenia; CESC cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg00033643 chr7:134001901 SLC35B4 0.42 5.28 0.31 2.73e-7 Mean platelet volume; CESC cis rs6062302 0.522 rs11696202 chr20:62246292 G/C cg06363034 chr20:62225388 GMEB2 -0.5 -6.35 -0.36 9.49e-10 Glioblastoma; CESC cis rs10911232 0.507 rs10732271 chr1:183025898 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 13.5 0.64 5.97e-32 Hypertriglyceridemia; CESC cis rs12477438 0.520 rs34252185 chr2:99737646 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.18 0.68 6.85e-38 Chronic sinus infection; CESC cis rs763121 0.853 rs4821808 chr22:39065739 A/G cg14440974 chr22:39074834 NA -0.41 -5.59 -0.32 5.61e-8 Menopause (age at onset); CESC cis rs909002 0.925 rs7524405 chr1:32108579 A/C cg13919466 chr1:32135498 COL16A1 0.48 8.51 0.46 1.27e-15 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16662489 chr10:14541114 NA -0.52 -6.11 -0.35 3.64e-9 Gut microbiome composition (summer); CESC cis rs561341 0.700 rs8079471 chr17:30218317 A/G cg13647721 chr17:30228624 UTP6 0.81 10.14 0.53 1.28e-20 Hip circumference adjusted for BMI; CESC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg17328964 chr8:145687451 CYHR1 0.41 5.98 0.34 7.19e-9 Age at first birth; CESC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg11663144 chr21:46675770 NA -0.63 -9.74 -0.51 2.3e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2576037 0.796 rs2576038 chr18:44582200 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -5.16 -0.3 4.9e-7 Personality dimensions; CESC cis rs2274273 0.870 rs3783650 chr14:55848972 A/C cg04306507 chr14:55594613 LGALS3 0.31 6.09 0.35 4.04e-9 Protein biomarker; CESC cis rs9611565 0.512 rs139573 chr22:42214785 G/A cg17376030 chr22:41985996 PMM1 0.77 8.15 0.45 1.47e-14 Vitiligo; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04148091 chr16:81348876 GAN 0.55 7.26 0.41 4.43e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2576037 0.796 rs2576038 chr18:44582200 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.45 5.87 0.34 1.33e-8 Personality dimensions; CESC cis rs1185460 0.967 rs1784460 chr11:118938371 A/T cg23280166 chr11:118938394 VPS11 -0.64 -9.58 -0.51 7.25e-19 Coronary artery disease; CESC cis rs753778 0.570 rs6578154 chr8:142210057 G/A cg18755752 chr8:142205143 DENND3 -0.63 -9.19 -0.49 1.2e-17 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27559595 chr15:79237381 CTSH 0.68 8.22 0.45 8.99e-15 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg08470875 chr2:26401718 FAM59B -0.62 -6.69 -0.38 1.35e-10 Gut microbiome composition (summer); CESC cis rs854765 0.547 rs4925135 chr17:17952868 T/C cg04398451 chr17:18023971 MYO15A 0.73 10.55 0.54 5.95e-22 Total body bone mineral density; CESC cis rs1008375 1.000 rs28545485 chr4:17645376 C/T cg02297831 chr4:17616191 MED28 0.53 6.71 0.38 1.2e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg15145296 chr3:125709740 NA -0.55 -6.63 -0.38 1.91e-10 Blood pressure (smoking interaction); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg27010136 chr7:1131122 GPER;C7orf50 -0.51 -6.37 -0.36 8.45e-10 Psoriatic arthritis; CESC cis rs9682041 0.932 rs1525362 chr3:170070702 C/T cg11886554 chr3:170076028 SKIL 0.82 6.83 0.39 5.75e-11 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.36 0.41 2.29e-12 Tonsillectomy; CESC cis rs7635838 0.892 rs754015 chr3:11493945 T/C cg00170343 chr3:11313890 ATG7 0.45 6.14 0.35 2.98e-9 HDL cholesterol; CESC cis rs644799 1.000 rs472231 chr11:95532166 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2952156 0.876 rs903504 chr17:37829570 C/G cg07936489 chr17:37558343 FBXL20 -0.59 -7.52 -0.42 8.39e-13 Asthma; CESC cis rs11711311 0.736 rs2278941 chr3:113350508 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.6 7.63 0.42 4.25e-13 IgG glycosylation; CESC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg04944784 chr2:26401820 FAM59B -0.79 -8.77 -0.47 2.26e-16 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.73 -9.22 -0.49 9.33e-18 Alzheimer's disease; CESC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg09491104 chr22:46646882 C22orf40 -0.49 -5.84 -0.34 1.53e-8 LDL cholesterol;Cholesterol, total; CESC cis rs738322 0.935 rs133014 chr22:38571087 T/G cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC cis rs2408955 0.541 rs11168428 chr12:48547128 A/G cg24011408 chr12:48396354 COL2A1 -0.49 -7.31 -0.41 3.2e-12 Glycated hemoglobin levels; CESC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.42 5.25 0.31 3.06e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9359856 0.600 rs11961825 chr6:90482250 T/A cg13799429 chr6:90582589 CASP8AP2 -0.64 -6.06 -0.35 4.56e-9 Bipolar disorder; CESC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.46 -0.54 1.15e-21 Alzheimer's disease; CESC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC trans rs11039798 0.623 rs588700 chr11:48449889 T/C cg15704280 chr7:45808275 SEPT13 -0.69 -6.7 -0.38 1.26e-10 Axial length; CESC cis rs9300255 0.664 rs7306755 chr12:123767929 G/A cg00376283 chr12:123451042 ABCB9 -0.62 -6.4 -0.37 7.02e-10 Neutrophil percentage of white cells; CESC cis rs35306767 0.903 rs11253504 chr10:956046 A/G cg26597838 chr10:835615 NA 0.98 10.69 0.55 2.06e-22 Eosinophil percentage of granulocytes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00222982 chr11:125439225 EI24 -0.39 -6.12 -0.35 3.37e-9 Gambling; CESC cis rs2479724 0.870 rs3747753 chr6:41753380 G/T cg17623882 chr6:41773611 USP49 0.42 5.99 0.35 6.95e-9 Menarche (age at onset); CESC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg00106254 chr7:1943704 MAD1L1 -0.49 -6.04 -0.35 5.23e-9 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13263114 chr17:37857070 ERBB2 -0.52 -6.21 -0.36 2.09e-9 Gut microbiome composition (summer); CESC cis rs959260 1.000 rs7211915 chr17:73379872 A/G cg12999837 chr17:73267436 MIF4GD -0.48 -5.58 -0.32 5.89e-8 Systemic lupus erythematosus; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03069383 chr2:18741691 RDH14 -0.46 -6.0 -0.35 6.59e-9 Ulcerative colitis; CESC cis rs2228479 0.850 rs12597299 chr16:89822364 C/A cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg13393036 chr8:95962371 TP53INP1 -0.47 -9.97 -0.52 4.26e-20 Type 2 diabetes; CESC cis rs9911578 1.000 rs1057068 chr17:56598439 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.27 -0.31 2.79e-7 Intelligence (multi-trait analysis); CESC cis rs4699052 0.662 rs6848091 chr4:104250101 A/G cg16532752 chr4:104119610 CENPE -0.41 -5.85 -0.34 1.43e-8 Testicular germ cell tumor; CESC trans rs3749237 1.000 rs2307021 chr3:49765483 C/G cg21659725 chr3:3221576 CRBN 0.55 6.62 0.38 1.93e-10 Resting heart rate; CESC cis rs4481887 0.830 rs6686474 chr1:248477116 A/C cg00666640 chr1:248458726 OR2T12 0.36 5.98 0.34 7.16e-9 Common traits (Other); CESC trans rs9929218 1.000 rs7186084 chr16:68816260 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.54 6.92 0.39 3.38e-11 Colorectal cancer; CESC cis rs916888 0.821 rs199504 chr17:44861003 C/T cg14517863 chr17:44321492 NA -0.41 -5.15 -0.3 5.15e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg22800045 chr5:56110881 MAP3K1 0.81 9.96 0.52 4.58e-20 Initial pursuit acceleration; CESC cis rs3796352 0.892 rs9756317 chr3:53088815 T/C cg07884673 chr3:53033167 SFMBT1 -0.64 -6.12 -0.35 3.42e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs4595586 0.545 rs11615718 chr12:39395335 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs8060686 0.641 rs75909028 chr16:68089578 A/C cg26727032 chr16:67993705 SLC12A4 -0.55 -6.15 -0.35 2.9e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs1878931 0.582 rs27238 chr16:3441223 G/A cg02880119 chr16:3481970 NA 0.42 5.26 0.31 2.94e-7 Body mass index (adult); CESC cis rs1775715 0.678 rs2778649 chr10:32146803 C/G cg18675610 chr10:32216311 ARHGAP12 0.35 5.51 0.32 8.38e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs2455799 0.613 rs4467435 chr3:15791671 A/G cg09340198 chr3:15902540 ANKRD28 -0.33 -5.16 -0.3 4.94e-7 Mean platelet volume; CESC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg04756594 chr16:24857601 SLC5A11 0.45 5.38 0.31 1.68e-7 Intelligence (multi-trait analysis); CESC cis rs72781680 1.000 rs6710426 chr2:24159288 A/G cg20701182 chr2:24300061 SF3B14 0.65 5.81 0.34 1.79e-8 Lymphocyte counts; CESC cis rs67311347 1.000 rs7634375 chr3:40431946 C/T cg09455208 chr3:40491958 NA 0.49 7.91 0.44 6.79e-14 Renal cell carcinoma; CESC cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.53e-8 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg23281280 chr6:28129359 ZNF389 0.59 8.07 0.44 2.52e-14 Depression; CESC cis rs7605827 0.930 rs2058868 chr2:15679609 A/T cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs6500602 0.893 rs8061742 chr16:4489436 T/C cg08645402 chr16:4508243 NA 0.38 5.36 0.31 1.84e-7 Schizophrenia; CESC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg08027265 chr7:2291960 NA -0.35 -5.07 -0.3 7.38e-7 Bipolar disorder and schizophrenia; CESC cis rs17376456 1.000 rs34854140 chr5:93538169 G/A cg21475434 chr5:93447410 FAM172A 0.86 7.69 0.43 2.82e-13 Diabetic retinopathy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10538454 chr17:48238843 NA -0.5 -6.61 -0.38 2.1e-10 Fibrinogen levels; CESC cis rs131805 0.794 rs131813 chr22:50961169 A/G cg25309564 chr22:51001381 C22orf41 0.67 6.94 0.39 3.03e-11 Granulocyte percentage of myeloid white cells; CESC trans rs5752128 1 rs5752128 chr22:25718623 T/C cg18115658 chr5:138720490 SLC23A1 0.52 6.44 0.37 5.6e-10 Monokine induced by gamma interferon levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16142977 chr19:3985688 EEF2 -0.62 -7.33 -0.41 2.84e-12 Gut microbiome composition (summer); CESC cis rs2204008 0.754 rs11514074 chr12:38401128 C/T cg13010199 chr12:38710504 ALG10B 0.54 6.83 0.39 5.71e-11 Bladder cancer; CESC trans rs8073060 0.586 rs72829927 chr17:34049992 A/G cg19694781 chr19:47549865 TMEM160 0.72 6.47 0.37 4.78e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs3820068 0.603 rs3795763 chr1:15959977 C/T cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.3100000000000001e-10 Systolic blood pressure; CESC cis rs4604732 0.631 rs80319072 chr1:247626835 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1971256 0.500 rs1971255 chr6:151816094 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.61 -5.92 -0.34 9.71e-9 Endometriosis; CESC cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg17366294 chr4:99064904 C4orf37 0.57 7.83 0.43 1.21e-13 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18948967 chr14:52119097 FRMD6 0.54 6.17 0.35 2.6e-9 Gut microbiome composition (summer); CESC cis rs2742234 0.541 rs10793422 chr10:43703874 G/A cg07801480 chr10:43725741 RASGEF1A -0.42 -5.37 -0.31 1.73e-7 Hirschsprung disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03232484 chr7:93633800 BET1 -0.44 -6.21 -0.36 2.07e-9 Gut microbiota (bacterial taxa); CESC cis rs2191566 0.960 rs12232810 chr19:44525122 A/G cg20607764 chr19:44506953 ZNF230 -0.58 -7.58 -0.42 5.8e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg03433033 chr1:76189801 ACADM 0.63 6.47 0.37 4.6e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs644799 1.000 rs632388 chr11:95563775 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.76 0.38 8.51e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg04317338 chr11:64019027 PLCB3 0.9 10.09 0.53 1.82e-20 Mean platelet volume; CESC cis rs9612 0.948 rs189408 chr19:44268006 T/C cg08581076 chr19:44259116 C19orf61 0.44 5.26 0.31 2.93e-7 Exhaled nitric oxide output; CESC cis rs8060686 0.545 rs9931987 chr16:68256639 G/A cg26727032 chr16:67993705 SLC12A4 -0.46 -5.4 -0.32 1.45e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs7130144 0.541 rs56097840 chr11:130462749 C/T cg26307797 chr11:130446613 NA -0.74 -6.5 -0.37 3.95e-10 Urate levels in lean individuals; CESC cis rs1371867 0.846 rs1788206 chr8:101306966 A/G cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.24e-11 Atrioventricular conduction; CESC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.49 0.37 4.1e-10 Bipolar disorder; CESC cis rs7296418 0.922 rs1790134 chr12:123697898 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.07 -0.3 7.34e-7 Platelet count; CESC cis rs36051895 0.659 rs12348771 chr9:5083634 T/C cg02405213 chr9:5042618 JAK2 -0.55 -6.66 -0.38 1.58e-10 Pediatric autoimmune diseases; CESC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.1e-18 Prudent dietary pattern; CESC trans rs4906172 0.898 rs10135027 chr14:102497772 A/G cg17920195 chr4:129149383 NA 0.33 6.52 0.37 3.6e-10 Menopause (age at onset); CESC cis rs854765 0.583 rs9913724 chr17:17819101 A/G cg04398451 chr17:18023971 MYO15A -0.67 -9.74 -0.51 2.33e-19 Total body bone mineral density; CESC cis rs10857712 0.950 rs7906765 chr10:135225460 G/T cg01444801 chr10:135216882 MTG1 -0.45 -5.32 -0.31 2.24e-7 Systemic lupus erythematosus; CESC cis rs644799 1.000 rs593665 chr11:95574302 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.94 13.75 0.65 7.53e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9790314 0.521 rs1376122 chr3:161087857 A/G cg03342759 chr3:160939853 NMD3 -0.41 -5.74 -0.33 2.52e-8 Morning vs. evening chronotype; CESC cis rs2795502 0.873 rs3123753 chr10:43404899 C/T cg27426351 chr10:43362370 NA 0.49 6.03 0.35 5.54e-9 Blood protein levels; CESC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg23048001 chr7:2026167 MAD1L1 0.48 6.26 0.36 1.57e-9 Bipolar disorder and schizophrenia; CESC cis rs8020095 0.571 rs7156119 chr14:67650115 C/T cg19548862 chr14:67692701 FAM71D -0.46 -5.53 -0.32 7.72e-8 Depression (quantitative trait); CESC cis rs7219021 0.669 rs35584414 chr17:47022727 C/G cg16584676 chr17:46985605 UBE2Z -0.64 -7.14 -0.4 9.18e-12 Schizophrenia or bipolar disorder; CESC cis rs9486719 0.948 rs6920913 chr6:96874297 A/G cg06623918 chr6:96969491 KIAA0776 0.9 10.2 0.53 8.21e-21 Migraine;Coronary artery disease; CESC cis rs7829975 0.840 rs555617 chr8:8592845 C/G cg06636001 chr8:8085503 FLJ10661 -0.46 -5.96 -0.34 8.13e-9 Mood instability; CESC cis rs523522 0.923 rs1048830 chr12:120882217 G/T cg27279351 chr12:120934652 DYNLL1 0.65 7.94 0.44 5.74e-14 High light scatter reticulocyte count; CESC cis rs6701037 0.748 rs2685 chr1:175127771 A/G cg00321850 chr1:175162397 KIAA0040 0.4 5.76 0.33 2.37e-8 Alcohol dependence; CESC cis rs8180040 1.000 rs1076394 chr3:47322781 G/A cg27129171 chr3:47204927 SETD2 -0.66 -10.07 -0.53 2.14e-20 Colorectal cancer; CESC trans rs57221529 0.600 rs11750269 chr5:666270 G/A cg25482853 chr8:67687455 SGK3 1.03 10.1 0.53 1.7e-20 Lung disease severity in cystic fibrosis; CESC cis rs7586879 0.551 rs7565460 chr2:25130073 C/T cg01884057 chr2:25150051 NA 0.37 7.08 0.4 1.27e-11 Body mass index; CESC cis rs7589342 0.895 rs2033008 chr2:106502585 T/A cg14210321 chr2:106509881 NCK2 -0.47 -5.37 -0.31 1.75e-7 Addiction; CESC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg14393609 chr7:65229607 NA -0.47 -6.28 -0.36 1.39e-9 Aortic root size; CESC cis rs7769051 0.522 rs34688576 chr6:133118214 C/T cg22852734 chr6:133119734 C6orf192 1.06 7.13 0.4 9.46e-12 Type 2 diabetes nephropathy; CESC cis rs2637266 1.000 rs2637270 chr10:78336901 C/T cg18941641 chr10:78392320 NA 0.41 7.62 0.42 4.6e-13 Pulmonary function; CESC cis rs8072100 0.738 rs9900123 chr17:45549055 T/C cg08085267 chr17:45401833 C17orf57 -0.54 -6.85 -0.39 5.15e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs3845702 0.736 rs2678936 chr2:180872179 G/C cg01881094 chr2:180872142 CWC22 1.11 10.12 0.53 1.45e-20 Schizophrenia; CESC trans rs801193 1.000 rs2707836 chr7:66160435 A/C cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC cis rs75804782 0.641 rs6715311 chr2:239363321 A/G cg18131467 chr2:239335373 ASB1 -0.68 -5.65 -0.33 4.08e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg23758822 chr17:41437982 NA 0.98 17.37 0.73 1.23e-45 Menopause (age at onset); CESC cis rs72781680 0.533 rs34668726 chr2:23895901 C/G cg20701182 chr2:24300061 SF3B14 0.74 6.96 0.39 2.61e-11 Lymphocyte counts; CESC cis rs2505675 0.665 rs234932 chr6:2220520 C/T cg16550324 chr6:2245327 GMDS 0.41 5.19 0.3 4.19e-7 Tuberculosis; CESC cis rs7089973 0.624 rs17586888 chr10:116598121 T/C cg03647239 chr10:116582469 FAM160B1 0.44 5.55 0.32 6.83e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6728642 0.908 rs10207116 chr2:98018281 G/A cg26665480 chr2:98280029 ACTR1B -0.81 -7.49 -0.42 1e-12 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs11958404 0.932 rs72816580 chr5:157432221 A/T cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg00310523 chr12:86230176 RASSF9 0.34 5.43 0.32 1.27e-7 Major depressive disorder; CESC trans rs7824557 0.564 rs7834572 chr8:11236685 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -6.15 -0.35 2.9e-9 Retinal vascular caliber; CESC cis rs4803468 1.000 rs284663 chr19:41932612 C/T cg14132834 chr19:41945861 ATP5SL -0.68 -8.4 -0.46 2.68e-15 Height; CESC cis rs35306767 0.953 rs12357633 chr10:957246 C/T cg26597838 chr10:835615 NA 0.98 10.69 0.55 2.06e-22 Eosinophil percentage of granulocytes; CESC cis rs4808199 0.895 rs12981405 chr19:19651577 C/T cg03709012 chr19:19516395 GATAD2A 1.0 9.88 0.52 8.15e-20 Nonalcoholic fatty liver disease; CESC cis rs2836950 0.501 rs2070865 chr21:40715519 C/T cg17971929 chr21:40555470 PSMG1 -0.51 -6.31 -0.36 1.16e-9 Menarche (age at onset); CESC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg09699651 chr6:150184138 LRP11 0.4 5.1 0.3 6.34e-7 Lung cancer; CESC cis rs9549367 0.789 rs2025247 chr13:113882564 C/G cg00898013 chr13:113819073 PROZ -0.49 -6.73 -0.38 1.05e-10 Platelet distribution width; CESC cis rs4704187 0.687 rs6453112 chr5:74389901 A/C cg03227963 chr5:74354835 NA 0.32 5.92 0.34 9.97e-9 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07371452 chr16:139780 C16orf35 -0.55 -5.99 -0.35 6.71e-9 Gut microbiome composition (summer); CESC cis rs1348850 0.526 rs1345138 chr2:178387100 A/T cg23306229 chr2:178417860 TTC30B 0.78 6.92 0.39 3.32e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.02 0.56 1.64e-23 Alzheimer's disease; CESC cis rs9303401 0.659 rs12600349 chr17:57054245 A/G cg10487724 chr17:56770010 TEX14;RAD51C -1.01 -12.41 -0.61 3.56e-28 Cognitive test performance; CESC cis rs9814567 0.752 rs6779326 chr3:134330027 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.09 -0.3 6.84e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs76878669 0.561 rs6591215 chr11:66170611 A/C cg18002602 chr11:66138449 SLC29A2 -0.3 -5.1 -0.3 6.39e-7 Educational attainment (years of education); CESC cis rs858239 0.601 rs6461702 chr7:23249273 C/G cg23682824 chr7:23144976 KLHL7 0.44 5.63 0.33 4.51e-8 Cerebrospinal fluid biomarker levels; CESC cis rs17253792 0.731 rs28587929 chr14:56097492 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.98 0.34 7.23e-9 Putamen volume; CESC cis rs875971 0.545 rs12671152 chr7:65776127 G/T cg18876405 chr7:65276391 NA 0.5 5.54 0.32 7.2e-8 Aortic root size; CESC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg19748678 chr4:122722346 EXOSC9 0.78 9.69 0.51 3.45e-19 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15995771 chr1:59250858 JUN 0.57 6.25 0.36 1.6e-9 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03066081 chr17:77784036 NA 0.49 6.61 0.38 2.11e-10 Systemic lupus erythematosus; CESC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg14159672 chr1:205819179 PM20D1 0.43 5.93 0.34 9.36e-9 Menarche (age at onset); CESC cis rs2456568 0.709 rs1546400 chr11:93639203 G/A cg26875233 chr11:93583750 C11orf90 0.3 5.27 0.31 2.77e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs7208859 0.623 rs6505207 chr17:29076571 T/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11785400 0.793 rs4403386 chr8:143736770 C/G cg10596483 chr8:143751796 JRK 0.43 5.41 0.32 1.37e-7 Schizophrenia; CESC cis rs7656342 0.686 rs10031303 chr4:9841690 A/T cg11266682 chr4:10021025 SLC2A9 0.33 5.22 0.31 3.55e-7 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11844697 chr17:80935769 B3GNTL1 -0.53 -6.07 -0.35 4.3e-9 Gut microbiome composition (summer); CESC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg25811766 chr13:21894605 NA 0.58 5.83 0.34 1.59e-8 White matter hyperintensity burden; CESC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg25405998 chr7:65216604 CCT6P1 -0.46 -5.22 -0.31 3.71e-7 Aortic root size; CESC cis rs1832871 0.672 rs9457362 chr6:158772052 C/T cg07165851 chr6:158734300 TULP4 0.58 6.19 0.36 2.31e-9 Height; CESC cis rs8050907 0.744 rs1362625 chr16:4526310 G/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs916888 0.610 rs199452 chr17:44801340 C/T cg01570182 chr17:44337453 NA 0.63 8.63 0.47 5.75e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10927875 0.632 rs4661667 chr1:16162731 C/T cg21385522 chr1:16154831 NA -1.02 -16.92 -0.72 4.74e-44 Dilated cardiomyopathy; CESC cis rs7129220 0.588 rs72860548 chr11:10128679 C/G cg01453529 chr11:10209919 SBF2 -0.47 -5.37 -0.31 1.7e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs2014572 0.967 rs7248000 chr19:57762139 C/T cg24459738 chr19:57751996 ZNF805 -0.56 -7.97 -0.44 4.64e-14 Hyperactive-impulsive symptoms; CESC cis rs4268898 0.662 rs35624938 chr2:24576651 T/C cg20701182 chr2:24300061 SF3B14 0.65 6.93 0.39 3.15e-11 Asthma; CESC cis rs4911259 0.552 rs2014837 chr20:31461082 C/T cg13636640 chr20:31349939 DNMT3B 0.57 7.97 0.44 4.66e-14 Inflammatory bowel disease; CESC cis rs6088813 1.000 rs6088821 chr20:33987576 G/A cg14752227 chr20:34000481 UQCC -0.4 -5.08 -0.3 7.17e-7 Height; CESC cis rs6736093 0.966 rs870763 chr2:112745481 C/T cg12686935 chr2:112915763 FBLN7 0.43 5.62 0.33 4.9e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15289517 chr15:65809633 DPP8 0.56 6.55 0.37 3.04e-10 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg27589368 chr17:43923255 LOC100128977;IMP5 -0.38 -5.35 -0.31 1.89e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg19622623 chr12:86230825 RASSF9 -0.47 -6.06 -0.35 4.65e-9 Major depressive disorder; CESC cis rs17253792 0.558 rs10083353 chr14:56066370 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.09 0.35 4.01e-9 Putamen volume; CESC cis rs2108622 0.727 rs7253684 chr19:15981126 C/T cg13772218 chr19:15982569 NA 0.3 5.87 0.34 1.27e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs4253772 0.591 rs6520010 chr22:46721223 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.78 9.23 0.49 8.88e-18 LDL cholesterol;Cholesterol, total; CESC cis rs4972806 0.849 rs2071581 chr2:177026148 G/T cg13092806 chr2:177043255 NA 0.46 6.72 0.38 1.12e-10 IgG glycosylation; CESC cis rs75477785 1.000 rs10489343 chr1:209984824 G/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg05368731 chr17:41323189 NBR1 -0.61 -8.42 -0.46 2.36e-15 Menopause (age at onset); CESC cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg19077165 chr18:44547161 KATNAL2 -0.53 -7.75 -0.43 1.94e-13 Personality dimensions; CESC cis rs17401966 0.838 rs4846197 chr1:10282166 G/A cg15208524 chr1:10270712 KIF1B 0.41 5.23 0.31 3.43e-7 Hepatocellular carcinoma; CESC cis rs1348850 0.914 rs6710575 chr2:178377311 C/T cg22681709 chr2:178499509 PDE11A -0.39 -5.47 -0.32 1.02e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7216064 0.684 rs8182243 chr17:66018505 T/C cg07042672 chr17:66097459 LOC651250 0.61 7.95 0.44 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7000551 0.715 rs7828610 chr8:22307326 C/T cg12081754 chr8:22256438 SLC39A14 0.44 5.91 0.34 1.07e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs55692411 0.537 rs71326904 chr3:49991060 C/T cg24110177 chr3:50126178 RBM5 -0.43 -5.1 -0.3 6.39e-7 Intelligence (multi-trait analysis); CESC trans rs8135828 0.770 rs2188120 chr22:29920819 A/C cg00674024 chr14:102829918 TECPR2;CINP 0.56 6.36 0.36 8.76e-10 Lipid traits; CESC cis rs965469 0.779 rs6037541 chr20:3287704 G/C cg25506879 chr20:3388711 C20orf194 -0.48 -5.31 -0.31 2.36e-7 IFN-related cytopenia; CESC cis rs7659604 0.605 rs1396080 chr4:122740454 T/G cg20573242 chr4:122745356 CCNA2 0.75 10.17 0.53 1e-20 Type 2 diabetes; CESC cis rs2011503 1.000 rs34067609 chr19:19653524 G/A cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs798766 1.000 rs2236786 chr4:1719294 T/C cg05874882 chr4:1763078 NA 0.61 7.32 0.41 3.06e-12 Bladder cancer;Urinary bladder cancer; CESC cis rs2243480 1.000 rs316322 chr7:65611233 G/C cg12463550 chr7:65579703 CRCP 0.74 5.79 0.33 2.02e-8 Diabetic kidney disease; CESC cis rs854765 0.583 rs4244602 chr17:17841456 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.53 7.27 0.41 3.96e-12 Total body bone mineral density; CESC cis rs8049040 0.609 rs16972805 chr16:71478249 A/G cg08717414 chr16:71523259 ZNF19 0.64 7.25 0.41 4.65e-12 Blood protein levels; CESC cis rs763121 0.853 rs5757253 chr22:39104320 C/T cg21395723 chr22:39101663 GTPBP1 0.5 6.82 0.39 6.16e-11 Menopause (age at onset); CESC cis rs2243480 0.708 rs35310401 chr7:65390359 A/G cg12463550 chr7:65579703 CRCP 0.7 5.58 0.32 5.87e-8 Diabetic kidney disease; CESC cis rs7940866 0.903 rs10750457 chr11:130850277 T/C cg12179176 chr11:130786555 SNX19 0.59 8.43 0.46 2.23e-15 Schizophrenia; CESC cis rs7267979 1.000 rs6050631 chr20:25431749 C/T cg08601574 chr20:25228251 PYGB 0.38 5.57 0.32 6.24e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs763121 0.853 rs2413545 chr22:39092524 C/T cg06544989 chr22:39130855 UNC84B 0.5 8.24 0.45 8.07e-15 Menopause (age at onset); CESC cis rs12618769 0.597 rs17504774 chr2:99135627 A/G cg10123293 chr2:99228465 UNC50 -0.38 -5.16 -0.3 4.92e-7 Bipolar disorder; CESC cis rs9291683 0.507 rs6849273 chr4:10021595 C/T cg02734326 chr4:10020555 SLC2A9 0.42 5.84 0.34 1.52e-8 Bone mineral density; CESC trans rs11770686 0.967 rs4728289 chr7:75348505 C/T cg16600432 chr14:64970085 ZBTB1;ZBTB25 -0.39 -6.02 -0.35 5.82e-9 Essential tremor; CESC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg05368731 chr17:41323189 NBR1 0.54 7.43 0.42 1.52e-12 Menopause (age at onset); CESC cis rs10206020 0.885 rs13411553 chr2:1574018 A/G cg26248373 chr2:1572462 NA -0.58 -6.78 -0.38 7.78e-11 IgG glycosylation; CESC cis rs4604732 0.812 rs6663238 chr1:247624971 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.39 -5.42 -0.32 1.31e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9814567 1.000 rs7433663 chr3:134235790 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.08 -0.35 4.09e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg02297831 chr4:17616191 MED28 0.44 5.64 0.33 4.43e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1153858 1.000 rs10519022 chr15:45663684 C/T cg14582100 chr15:45693742 SPATA5L1 -0.43 -6.1 -0.35 3.81e-9 Homoarginine levels; CESC cis rs738322 0.967 rs133013 chr22:38570912 C/T cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC trans rs1116547 0.531 rs7707443 chr5:112790219 C/T cg10115368 chr14:100435663 NA 0.5 6.01 0.35 6.04e-9 Cerebral amyloid angiopathy; CESC cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg24450063 chr1:156163899 SLC25A44 1.11 23.64 0.82 3.21e-67 Testicular germ cell tumor; CESC cis rs12681288 0.823 rs4735974 chr8:1000218 T/G cg04851639 chr8:1020857 NA -0.32 -7.17 -0.4 7.66e-12 Schizophrenia; CESC cis rs11785693 0.862 rs17351027 chr8:4987098 A/G cg26367366 chr8:4980734 NA -0.61 -5.95 -0.34 8.47e-9 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs7828089 0.934 rs12544427 chr8:22263115 C/T cg13512537 chr8:22265999 SLC39A14 0.37 5.31 0.31 2.31e-7 Verbal declarative memory; CESC cis rs12130219 1.000 rs12130219 chr1:152162106 A/G cg17718321 chr1:152188247 HRNR 0.41 5.45 0.32 1.18e-7 Inflammatory skin disease; CESC cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg14703610 chr5:56206110 C5orf35 -0.45 -5.46 -0.32 1.07e-7 Coronary artery disease; CESC cis rs962856 0.575 rs1486134 chr2:67639769 G/T cg09028215 chr2:67624308 ETAA1 -0.41 -5.1 -0.3 6.58e-7 Pancreatic cancer; CESC cis rs9814567 1.000 rs2373865 chr3:134291556 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.1 0.35 3.71e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4925386 1.000 rs6121990 chr20:60919263 G/A cg24112000 chr20:60950667 NA 0.51 7.59 0.42 5.58e-13 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs11792861 0.816 rs113624314 chr9:111689953 G/A cg13535736 chr9:111863775 C9orf5 -0.46 -6.08 -0.35 4.28e-9 Menarche (age at onset); CESC cis rs10751667 0.621 rs11246345 chr11:934924 T/C cg20946044 chr11:1010712 AP2A2 -0.4 -5.43 -0.32 1.26e-7 Alzheimer's disease (late onset); CESC cis rs72781680 1.000 rs72796359 chr2:24160545 T/C cg20701182 chr2:24300061 SF3B14 0.78 6.82 0.39 5.98e-11 Lymphocyte counts; CESC cis rs711245 0.573 rs7570763 chr2:36800589 A/C cg15105969 chr2:36825350 FEZ2 -0.45 -5.18 -0.3 4.37e-7 Height; CESC cis rs561341 1.000 rs1557731 chr17:30321567 T/G cg19193384 chr17:30244184 NA -0.61 -6.39 -0.37 7.37e-10 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25371038 chr22:22337141 TOP3B 0.68 7.3 0.41 3.35e-12 Gut microbiome composition (summer); CESC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg18446336 chr7:2847575 GNA12 -0.44 -7.38 -0.41 2.04e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg16339924 chr4:17578868 LAP3 0.71 9.08 0.49 2.58e-17 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs72772090 0.539 rs55996659 chr5:96114150 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.68 -0.33 3.57e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs921968 0.541 rs581013 chr2:219432040 G/T cg15547669 chr20:2781122 CPXM1 0.36 6.01 0.35 5.97e-9 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25940730 chr4:16228647 TAPT1;FLJ39653 0.57 6.39 0.37 7.57e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs11642010 chr16:89845111 T/C cg14709524 chr16:89940631 TCF25 0.75 5.07 0.3 7.38e-7 Skin colour saturation; CESC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg07936489 chr17:37558343 FBXL20 0.8 11.69 0.58 9.64e-26 Glomerular filtration rate (creatinine); CESC cis rs704 0.605 rs2071379 chr17:26695832 A/G cg10342447 chr17:26645325 TMEM97 -0.42 -6.04 -0.35 5.17e-9 Osteoprotegerin levels; CESC cis rs748404 0.660 rs2439845 chr15:43722610 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.62 0.42 4.42e-13 Lung cancer; CESC cis rs4243830 0.737 rs11581831 chr1:6609958 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -8.42 -0.46 2.37e-15 Body mass index; CESC cis rs1570884 0.857 rs9535263 chr13:50137363 T/A cg08779649 chr13:50194554 NA 0.32 5.2 0.3 3.93e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg27094323 chr7:1216898 NA -0.37 -5.36 -0.31 1.81e-7 Longevity;Endometriosis; CESC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg26314531 chr2:26401878 FAM59B -0.61 -6.85 -0.39 5.02e-11 Gut microbiome composition (summer); CESC cis rs2806561 0.808 rs1413974 chr1:23347125 C/T cg12483005 chr1:23474871 LUZP1 -0.35 -5.41 -0.32 1.43e-7 Height; CESC cis rs367943 0.712 rs9326887 chr5:112728581 T/A cg12552261 chr5:112820674 MCC 0.38 5.08 0.3 7.02e-7 Type 2 diabetes; CESC cis rs7179456 0.547 rs6494035 chr15:59015888 C/G cg05156742 chr15:59063176 FAM63B 0.57 7.3 0.41 3.33e-12 Asperger disorder; CESC cis rs4718428 0.672 rs13241598 chr7:66300652 A/G cg18252515 chr7:66147081 NA -0.47 -5.24 -0.31 3.23e-7 Corneal structure; CESC cis rs2228479 0.850 rs62054601 chr16:89811751 C/G cg04013166 chr16:89971882 TCF25 0.78 6.74 0.38 9.93e-11 Skin colour saturation; CESC cis rs752010 0.746 rs11210499 chr1:42089703 C/T cg12614395 chr1:42085415 HIVEP3 -0.31 -5.31 -0.31 2.28e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs10465746 0.846 rs9700285 chr1:84336685 G/A cg10977910 chr1:84465055 TTLL7 0.48 6.5 0.37 3.92e-10 Obesity-related traits; CESC cis rs727563 0.636 rs2413653 chr22:42106996 T/C cg06481639 chr22:41940642 POLR3H 0.6 6.04 0.35 5.18e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs698833 0.886 rs786654 chr2:44581007 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.8 0.34 1.84e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg14562523 chr21:43528734 C21orf128;UMODL1 -0.46 -7.18 -0.4 7.07e-12 IgG glycosylation; CESC cis rs6696846 0.765 rs11577406 chr1:205065733 G/T cg00857998 chr1:205179979 DSTYK 0.56 7.36 0.41 2.27e-12 Red blood cell count; CESC cis rs10883723 0.810 rs12265877 chr10:104247247 C/G cg22532475 chr10:104410764 TRIM8 -0.34 -5.72 -0.33 2.86e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs1371867 0.875 rs1660344 chr8:101324659 A/G cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.1e-11 Atrioventricular conduction; CESC cis rs11098499 0.569 rs55845118 chr4:120290913 T/C cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg06627628 chr2:24431161 ITSN2 -0.66 -6.24 -0.36 1.69e-9 Lymphocyte counts; CESC cis rs4953318 0.619 rs13406773 chr2:46362868 T/C cg12428440 chr2:46370979 PRKCE 0.49 6.59 0.38 2.31e-10 Red blood cell count;Hematocrit;Red blood cell traits; CESC cis rs6088580 0.713 rs1884669 chr20:33171287 G/A cg06115741 chr20:33292138 TP53INP2 0.51 6.51 0.37 3.71e-10 Glomerular filtration rate (creatinine); CESC cis rs17253792 0.822 rs80321745 chr14:56162947 T/A cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg10556349 chr10:835070 NA 0.76 6.39 0.37 7.22e-10 Eosinophil percentage of granulocytes; CESC cis rs8067354 0.645 rs2645467 chr17:57854783 C/T cg02344993 chr17:57696989 CLTC 0.67 8.32 0.46 4.71e-15 Hemoglobin concentration; CESC cis rs742614 0.533 rs6059499 chr20:32447920 C/T cg06304546 chr20:32448765 NA 0.47 6.01 0.35 5.96e-9 Stearic acid (18:0) levels; CESC cis rs7608623 0.679 rs4665652 chr2:24250023 G/A cg20701182 chr2:24300061 SF3B14 -0.4 -5.34 -0.31 2.01e-7 Obesity-related traits; CESC cis rs10276381 0.579 rs73072539 chr7:28146255 C/G cg23620719 chr7:28220237 JAZF1 0.65 5.19 0.3 4.13e-7 Crohn's disease; CESC cis rs208520 0.821 rs9363572 chr6:67012231 C/T cg07460842 chr6:66804631 NA 0.84 8.13 0.45 1.67e-14 Exhaled nitric oxide output; CESC cis rs7607369 0.714 rs4674338 chr2:219647487 A/G cg02176678 chr2:219576539 TTLL4 0.46 8.14 0.45 1.51e-14 Red blood cell count;Amyotrophic lateral sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21099326 chr8:27168591 TRIM35;PTK2B 0.57 6.57 0.37 2.67e-10 Gut microbiome composition (summer); CESC trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.4 -0.46 2.71e-15 Intelligence (multi-trait analysis); CESC cis rs4835473 0.932 rs1450250 chr4:144653026 A/G cg25736465 chr4:144833511 NA 0.37 5.67 0.33 3.72e-8 Immature fraction of reticulocytes; CESC trans rs9467711 0.606 rs68112369 chr6:26365759 T/C cg06606381 chr12:133084897 FBRSL1 -0.77 -6.97 -0.39 2.57e-11 Autism spectrum disorder or schizophrenia; CESC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg18230493 chr5:56204884 C5orf35 -0.66 -8.28 -0.45 6.32e-15 Initial pursuit acceleration; CESC cis rs11252926 0.599 rs11252213 chr10:454694 C/T cg18196295 chr10:418757 DIP2C 0.52 7.06 0.4 1.49e-11 Psychosis in Alzheimer's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06825833 chr13:111566802 ANKRD10 0.51 6.57 0.37 2.66e-10 Gut microbiota (bacterial taxa); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24294857 chr1:20812821 CAMK2N1 -0.43 -6.18 -0.35 2.46e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg21782813 chr7:2030301 MAD1L1 0.4 5.83 0.34 1.57e-8 Bipolar disorder and schizophrenia; CESC cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg06627628 chr2:24431161 ITSN2 0.68 6.46 0.37 4.88e-10 Lymphocyte counts; CESC cis rs10791323 0.582 rs2851120 chr11:133708065 A/G cg15485101 chr11:133734466 NA 0.37 6.26 0.36 1.55e-9 Childhood ear infection; CESC cis rs116095464 0.558 rs56298907 chr5:283280 C/A cg22496380 chr5:211416 CCDC127 -0.99 -10.19 -0.53 8.71e-21 Breast cancer; CESC cis rs9584850 0.718 rs6491427 chr13:99113166 A/G cg20750642 chr13:99100586 FARP1 -0.39 -5.91 -0.34 1.05e-8 Neuroticism; CESC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg04756594 chr16:24857601 SLC5A11 0.5 5.82 0.34 1.7e-8 Intelligence (multi-trait analysis); CESC cis rs59698941 0.943 rs997633 chr5:132219304 A/T cg02081065 chr5:132209139 LEAP2 -0.52 -5.11 -0.3 6.08e-7 Apolipoprotein A-IV levels; CESC cis rs34734847 0.750 rs3915 chr12:121176679 C/T cg21892295 chr12:121157589 UNC119B -0.34 -5.29 -0.31 2.53e-7 Mean corpuscular volume; CESC cis rs7726839 0.794 rs10053310 chr5:595661 C/G cg16447950 chr5:562315 NA -0.49 -5.75 -0.33 2.39e-8 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11923054 chr4:4250051 TMEM128 -0.57 -6.71 -0.38 1.17e-10 Gut microbiome composition (summer); CESC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg15369054 chr17:80825471 TBCD -0.47 -6.74 -0.38 1.01e-10 Breast cancer; CESC cis rs9611519 0.780 rs9611546 chr22:41698542 C/G cg03806693 chr22:41940476 POLR3H -0.78 -8.82 -0.48 1.58e-16 Neuroticism; CESC cis rs3126085 0.867 rs36033453 chr1:152221226 T/G cg03465714 chr1:152285911 FLG 0.45 5.37 0.31 1.73e-7 Atopic dermatitis; CESC cis rs2625529 0.652 rs2930069 chr15:72226977 G/A cg16672083 chr15:72433130 SENP8 0.41 6.24 0.36 1.72e-9 Red blood cell count; CESC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs7851660 0.772 rs6478471 chr9:100664382 A/G cg13688889 chr9:100608707 NA -0.62 -8.83 -0.48 1.5e-16 Strep throat; CESC cis rs1729951 0.575 rs12494558 chr3:136678781 C/G cg03617693 chr3:136751559 NA 0.38 5.33 0.31 2.08e-7 Neuroticism; CESC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg26335602 chr6:28129616 ZNF389 0.45 5.57 0.32 6.23e-8 Parkinson's disease; CESC cis rs11650494 0.908 rs77247327 chr17:47411493 T/C cg08112188 chr17:47440006 ZNF652 1.31 8.52 0.46 1.22e-15 Prostate cancer; CESC cis rs5769707 0.967 rs9616701 chr22:50025546 G/A cg05373962 chr22:49881684 NA -0.39 -6.81 -0.39 6.45e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs863345 0.967 rs12121983 chr1:158510273 A/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.59 -0.38 2.3e-10 Pneumococcal bacteremia; CESC cis rs16866061 1.000 rs72974203 chr2:225408430 G/A cg12698349 chr2:225449008 CUL3 0.74 11.36 0.57 1.3e-24 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg06420487 chr17:61919686 SMARCD2 0.47 5.59 0.32 5.68e-8 Height; CESC cis rs7071206 0.947 rs1877998 chr10:79411740 C/T cg00983440 chr10:79422392 NA -0.66 -7.97 -0.44 4.74e-14 Bone mineral density; CESC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg03576123 chr11:487126 PTDSS2 -1.11 -11.13 -0.56 7.09e-24 Body mass index; CESC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg06481639 chr22:41940642 POLR3H -0.61 -6.39 -0.37 7.34e-10 Vitiligo; CESC cis rs7267979 1.000 rs2257420 chr20:25275890 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs921968 0.541 rs620596 chr2:219462419 G/A cg02176678 chr2:219576539 TTLL4 0.48 8.45 0.46 2e-15 Mean corpuscular hemoglobin concentration; CESC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.52 7.86 0.43 9.89e-14 Bipolar disorder; CESC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.61 0.38 2.05e-10 Prudent dietary pattern; CESC cis rs7843479 0.965 rs733543 chr8:21835465 A/G cg17168535 chr8:21777572 XPO7 0.51 7.2 0.4 6.27e-12 Mean corpuscular volume; CESC cis rs7208859 0.673 rs1347359 chr17:28914529 T/C cg19761014 chr17:28927070 LRRC37B2 0.79 7.2 0.4 6.08e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.68 0.61 4e-29 Gut microbiome composition (summer); CESC cis rs7615952 0.932 rs13314869 chr3:125644669 G/A cg05084668 chr3:125655381 ALG1L -0.52 -6.14 -0.35 3.02e-9 Blood pressure (smoking interaction); CESC cis rs703842 0.928 rs724834 chr12:58180416 G/C cg00677455 chr12:58241039 CTDSP2 0.52 6.57 0.37 2.68e-10 Multiple sclerosis; CESC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg10128416 chr1:75198403 TYW3;CRYZ 0.48 6.5 0.37 4.07e-10 Resistin levels; CESC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg03188948 chr7:1209495 NA 0.7 6.78 0.38 7.86e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs854765 0.619 rs4561528 chr17:17979099 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.64 0.47 5.5e-16 Total body bone mineral density; CESC cis rs3126085 0.935 rs12409762 chr1:152175398 G/A cg03465714 chr1:152285911 FLG 0.49 5.98 0.34 7.36e-9 Atopic dermatitis; CESC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs2735413 0.881 rs12919672 chr16:78082760 C/G cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs453301 0.686 rs11787026 chr8:8902371 A/T cg15556689 chr8:8085844 FLJ10661 0.47 5.9 0.34 1.1e-8 Joint mobility (Beighton score); CESC cis rs4660306 0.614 rs781057 chr1:45936017 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.2 0.3 3.91e-7 Homocysteine levels; CESC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL -0.55 -5.63 -0.33 4.62e-8 Depression; CESC cis rs2243480 1.000 rs56016656 chr7:65383481 C/T cg13147721 chr7:65941812 NA -0.88 -8.15 -0.45 1.47e-14 Diabetic kidney disease; CESC cis rs2820292 0.619 rs41299585 chr1:201853165 G/T cg06775570 chr1:201857621 SHISA4 -0.33 -5.31 -0.31 2.32e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs2760061 0.583 rs3094911 chr1:228210179 A/G cg02753203 chr1:228287806 NA 0.76 11.42 0.57 7.89e-25 Diastolic blood pressure; CESC cis rs710865 0.627 rs10799710 chr1:19483209 A/G cg13387374 chr1:19411106 UBR4 0.55 7.48 0.42 1.08e-12 Brain structure; CESC cis rs2239547 0.522 rs6445550 chr3:52983434 G/A cg11645453 chr3:52864694 ITIH4 0.32 5.33 0.31 2.06e-7 Schizophrenia; CESC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.56 0.37 2.83e-10 Prudent dietary pattern; CESC cis rs2991971 0.810 rs2356413 chr1:45914048 A/T cg05343316 chr1:45956843 TESK2 0.59 8.4 0.46 2.68e-15 High light scatter reticulocyte count; CESC cis rs9291683 0.526 rs6827785 chr4:10018205 C/T cg00071950 chr4:10020882 SLC2A9 0.82 13.82 0.65 4.37e-33 Bone mineral density; CESC cis rs9611565 0.694 rs7285041 chr22:41829149 G/T cg06481639 chr22:41940642 POLR3H 0.63 6.29 0.36 1.27e-9 Vitiligo; CESC cis rs72781680 0.799 rs2712084 chr2:24003051 A/G cg08917208 chr2:24149416 ATAD2B 0.61 5.99 0.35 6.76e-9 Lymphocyte counts; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11498079 chr5:173043766 BOD1 -0.48 -6.57 -0.37 2.6200000000000003e-10 Fibrinogen levels; CESC cis rs763014 0.931 rs2071982 chr16:630405 T/G cg00802000 chr16:706648 WDR90 -0.42 -6.36 -0.36 8.74e-10 Height; CESC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg19774624 chr17:42201019 HDAC5 0.71 10.48 0.54 1.01e-21 Total body bone mineral density; CESC cis rs72781680 0.752 rs72796138 chr2:23926233 C/T cg20701182 chr2:24300061 SF3B14 0.79 7.0 0.39 2.12e-11 Lymphocyte counts; CESC cis rs12887734 0.546 rs12886637 chr14:104222892 A/G cg01849466 chr14:104193079 ZFYVE21 0.43 5.48 0.32 9.92e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs722599 0.748 rs55707505 chr14:75362552 T/C cg08847533 chr14:75593920 NEK9 -0.47 -5.72 -0.33 2.88e-8 IgG glycosylation; CESC cis rs7659604 0.605 rs67772833 chr4:122723106 G/A cg19671926 chr4:122722719 EXOSC9 -0.51 -6.1 -0.35 3.65e-9 Type 2 diabetes; CESC cis rs1501550 0.541 rs11119666 chr1:211201592 G/A cg23086161 chr1:211307217 KCNH1 -0.33 -5.15 -0.3 5.1e-7 Circulating vasoactive peptide levels; CESC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg18446336 chr7:2847575 GNA12 -0.36 -5.43 -0.32 1.29e-7 Height; CESC cis rs78456975 0.628 rs13426896 chr2:1554768 C/T cg01028140 chr2:1542097 TPO -0.47 -5.29 -0.31 2.6e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs6089584 0.528 rs881994 chr20:60623931 G/A cg06108461 chr20:60628389 TAF4 -0.6 -8.03 -0.44 3.26e-14 Body mass index; CESC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg19592336 chr6:28129416 ZNF389 0.57 7.41 0.41 1.68e-12 Parkinson's disease; CESC cis rs3096299 0.566 rs4129126 chr16:89561475 A/C cg08392591 chr16:89556376 ANKRD11 0.42 5.09 0.3 6.66e-7 Multiple myeloma (IgH translocation); CESC cis rs9916302 0.904 rs4795359 chr17:37573146 C/T cg15445000 chr17:37608096 MED1 0.41 6.74 0.38 9.67e-11 Glomerular filtration rate (creatinine); CESC cis rs2760061 0.599 rs849903 chr1:228137659 T/C cg01973587 chr1:228161476 NA 0.37 5.64 0.33 4.43e-8 Diastolic blood pressure; CESC cis rs4243830 0.850 rs12410405 chr1:6581283 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.86 9.39 0.5 2.85e-18 Body mass index; CESC cis rs9790314 1.000 rs9790314 chr3:161019558 T/C cg03342759 chr3:160939853 NMD3 -0.5 -6.9 -0.39 3.8e-11 Morning vs. evening chronotype; CESC cis rs8020095 0.571 rs10138865 chr14:67606802 C/T cg19548862 chr14:67692701 FAM71D -0.48 -5.7 -0.33 3.12e-8 Depression (quantitative trait); CESC cis rs11098499 0.909 rs7659501 chr4:120371552 G/T cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg10074409 chr1:209979377 IRF6 0.37 5.98 0.35 7.05e-9 Cleft lip with or without cleft palate; CESC cis rs1348850 0.789 rs13027959 chr2:178275887 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.75 10.73 0.55 1.57e-22 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg03433033 chr1:76189801 ACADM -0.63 -6.01 -0.35 6.27e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg23281280 chr6:28129359 ZNF389 0.59 7.91 0.44 7.14e-14 Depression; CESC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.64 8.72 0.47 3.02e-16 Menarche (age at onset); CESC cis rs858239 0.676 rs274032 chr7:23374559 C/G cg23682824 chr7:23144976 KLHL7 0.45 6.04 0.35 5.24e-9 Cerebrospinal fluid biomarker levels; CESC trans rs561341 0.941 rs17780080 chr17:30343146 G/A cg20587970 chr11:113659929 NA -1.5 -18.59 -0.75 5.81e-50 Hip circumference adjusted for BMI; CESC cis rs9905704 0.846 rs11079356 chr17:56864242 C/A cg12560992 chr17:57184187 TRIM37 0.62 7.8 0.43 1.45e-13 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.85 0.48 1.3e-16 Colonoscopy-negative controls vs population controls; CESC trans rs66573146 0.656 rs41410847 chr4:6957332 C/T cg07817883 chr1:32538562 TMEM39B 0.89 7.36 0.41 2.29e-12 Granulocyte percentage of myeloid white cells; CESC trans rs2018683 0.768 rs10282015 chr7:29022138 G/A cg19402173 chr7:128379420 CALU -0.6 -7.48 -0.42 1.13e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg24250549 chr1:154909240 PMVK 0.62 8.68 0.47 4.03e-16 Prostate cancer; CESC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg08704250 chr15:31115839 NA -0.68 -9.07 -0.49 2.76e-17 Huntington's disease progression; CESC cis rs12824058 0.831 rs11616174 chr12:130814503 A/G cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg14440974 chr22:39074834 NA 0.45 6.2 0.36 2.15e-9 Menopause (age at onset); CESC cis rs36051895 0.632 rs7038813 chr9:5177685 A/G cg02405213 chr9:5042618 JAK2 -0.51 -6.55 -0.37 2.91e-10 Pediatric autoimmune diseases; CESC cis rs6775745 0.654 rs2141572 chr3:131788366 G/A cg12213930 chr3:131751605 CPNE4 0.46 5.25 0.31 3.08e-7 Neutrophil count; CESC cis rs1801251 1.000 rs1446308 chr2:233639309 T/C cg08000102 chr2:233561755 GIGYF2 0.66 9.35 0.5 3.7e-18 Coronary artery disease; CESC cis rs7605378 1.000 rs10194076 chr2:200677663 T/C cg23649088 chr2:200775458 C2orf69 0.5 6.45 0.37 5.39e-10 Osteoporosis; CESC cis rs9811920 0.609 rs793462 chr3:99616461 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05922971 chr5:43121458 ZNF131 0.6 7.34 0.41 2.64e-12 Gut microbiome composition (summer); CESC trans rs11696739 1.000 rs11696739 chr20:1600925 A/G cg13912702 chr13:113520917 ATP11A 0.47 6.11 0.35 3.49e-9 Mean platelet volume; CESC cis rs9457247 0.765 rs9457249 chr6:167426438 A/G cg07741184 chr6:167504864 NA 0.35 6.44 0.37 5.64e-10 Crohn's disease; CESC cis rs9948 1.000 rs59244622 chr2:97501632 C/T cg01990225 chr2:97406019 LMAN2L -0.69 -5.03 -0.3 8.93e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs11792861 0.926 rs118011482 chr9:111770626 G/C cg13535736 chr9:111863775 C9orf5 -0.49 -6.35 -0.36 9.42e-10 Menarche (age at onset); CESC cis rs365132 1.000 rs402511 chr5:176434440 G/A cg16309518 chr5:176445507 NA -0.37 -5.35 -0.31 1.9e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg25036284 chr2:26402008 FAM59B 0.86 9.36 0.5 3.44e-18 Gut microbiome composition (summer); CESC cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg10556349 chr10:835070 NA 0.51 5.43 0.32 1.3e-7 Eosinophil percentage of granulocytes; CESC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg04944784 chr2:26401820 FAM59B 0.93 10.26 0.53 5.24e-21 Gut microbiome composition (summer); CESC cis rs524281 0.861 rs11227410 chr11:65873396 G/C cg14036092 chr11:66035641 RAB1B -0.62 -6.35 -0.36 9.06e-10 Electroencephalogram traits; CESC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg06877462 chr1:205807181 PM20D1 0.37 5.34 0.31 1.98e-7 Menarche (age at onset); CESC trans rs61931739 0.749 rs11053093 chr12:34231095 A/G cg26384229 chr12:38710491 ALG10B 0.49 6.73 0.38 1.02e-10 Morning vs. evening chronotype; CESC cis rs933688 0.532 rs13164949 chr5:90538489 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.45 -5.16 -0.3 4.73e-7 Smoking behavior; CESC cis rs6088580 0.634 rs6088502 chr20:33037644 A/T cg24642439 chr20:33292090 TP53INP2 0.51 6.74 0.38 9.69e-11 Glomerular filtration rate (creatinine); CESC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg06456125 chr7:65229604 NA -0.4 -5.15 -0.3 5.11e-7 Aortic root size; CESC cis rs12900413 0.603 rs2351493 chr15:90299536 A/G cg24249390 chr15:90295951 MESP1 -0.38 -5.08 -0.3 7.22e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs2944591 0.505 rs2592118 chr2:233792425 C/T cg11972305 chr2:233791962 NGEF -0.38 -6.18 -0.35 2.41e-9 Autism spectrum disorder or schizophrenia; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg01953317 chr2:55642894 CCDC88A 0.44 6.88 0.39 4.35e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7335046 0.536 rs61970284 chr13:99918771 C/T cg21788972 chr13:99853209 UBAC2 -0.43 -5.4 -0.31 1.49e-7 Basal cell carcinoma; CESC cis rs914615 0.552 rs7556304 chr1:155139509 T/C cg02153340 chr1:155202674 NA -0.37 -5.39 -0.31 1.56e-7 Urinary albumin-to-creatinine ratio; CESC cis rs7267979 1.000 rs4815426 chr20:25405186 A/C cg08601574 chr20:25228251 PYGB -0.37 -5.39 -0.31 1.53e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs1448094 0.765 rs4919773 chr12:86337559 C/T cg02569458 chr12:86230093 RASSF9 0.45 6.34 0.36 9.64e-10 Major depressive disorder; CESC cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.01 0.35 6.09e-9 Colorectal cancer; CESC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg10800226 chr5:1850261 NA 0.34 5.62 0.33 4.84e-8 Cardiovascular disease risk factors; CESC cis rs1050631 1.000 rs1785919 chr18:33691964 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.44 5.7 0.33 3.22e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs10911232 0.560 rs6697320 chr1:183037377 T/G ch.1.3577855R chr1:183094577 LAMC1 0.82 12.63 0.61 6.02e-29 Hypertriglyceridemia; CESC cis rs6963495 0.818 rs73192105 chr7:105167945 T/C cg19920283 chr7:105172520 RINT1 0.68 6.44 0.37 5.53e-10 Bipolar disorder (body mass index interaction); CESC cis rs826838 0.933 rs980573 chr12:39127811 T/C cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.44 -0.32 1.2e-7 Huntington's disease progression; CESC cis rs662064 0.748 rs2506892 chr1:10598216 G/A cg20482658 chr1:10539492 PEX14 0.41 8.41 0.46 2.64e-15 Asthma; CESC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 8.23 0.45 8.74e-15 Bipolar disorder; CESC cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg24531977 chr5:56204891 C5orf35 -0.9 -11.69 -0.58 1.01e-25 Initial pursuit acceleration; CESC cis rs6831352 0.918 rs1042365 chr4:100045500 G/T cg12011299 chr4:100065546 ADH4 -0.59 -6.72 -0.38 1.09e-10 Alcohol dependence; CESC cis rs9486719 1.000 rs12530462 chr6:97053514 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -8.43 -0.46 2.29e-15 Migraine;Coronary artery disease; CESC trans rs9467711 0.606 rs9379855 chr6:26364930 C/T cg06606381 chr12:133084897 FBRSL1 0.74 7.28 0.41 3.86e-12 Autism spectrum disorder or schizophrenia; CESC trans rs11098499 0.687 rs71610270 chr4:120287436 A/G cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs875971 0.545 rs7810213 chr7:65946579 G/C cg11764359 chr7:65958608 NA 0.82 9.18 0.49 1.27e-17 Aortic root size; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02205181 chr10:104154811 NFKB2 0.46 6.21 0.36 2.08e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05924212 chr2:30455114 LBH -0.57 -6.58 -0.37 2.52e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.79 8.79 0.47 1.98e-16 Alzheimer's disease; CESC cis rs854765 0.547 rs2955372 chr17:17970229 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.49 -6.2 -0.36 2.1e-9 Total body bone mineral density; CESC cis rs11638352 0.661 rs2114422 chr15:44420244 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -5.29 -0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg02592271 chr2:27665507 KRTCAP3 -0.3 -6.02 -0.35 5.84e-9 Total body bone mineral density; CESC cis rs1044826 0.642 rs7624321 chr3:139220159 C/A cg00490450 chr3:139108681 COPB2 0.45 5.53 0.32 7.8e-8 Obesity-related traits; CESC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs12410462 0.581 rs6675521 chr1:227544702 C/T cg04117972 chr1:227635322 NA 0.62 5.31 0.31 2.27e-7 Major depressive disorder; CESC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg07870213 chr5:140052090 DND1 -0.6 -6.8 -0.39 7.02e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10751667 1.000 rs6597972 chr11:928402 C/T cg20946044 chr11:1010712 AP2A2 -0.42 -5.53 -0.32 7.87e-8 Alzheimer's disease (late onset); CESC cis rs916888 0.773 rs199534 chr17:44824213 T/G cg01570182 chr17:44337453 NA 0.91 10.31 0.53 3.6e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.86 -0.34 1.4e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7116495 1.000 rs7124000 chr11:71754338 T/C cg26138937 chr11:71823887 C11orf51 -0.71 -6.19 -0.36 2.33e-9 Severe influenza A (H1N1) infection; CESC cis rs2952156 0.920 rs732084 chr17:37834357 A/C cg00129232 chr17:37814104 STARD3 -0.73 -10.6 -0.55 4.07e-22 Asthma; CESC cis rs365132 1.000 rs353490 chr5:176433063 C/T cg16309518 chr5:176445507 NA -0.37 -5.35 -0.31 1.9e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.47 -0.37 4.81e-10 Life satisfaction; CESC cis rs10791097 0.694 rs4436551 chr11:130755739 A/G cg09137382 chr11:130731461 NA -0.37 -5.66 -0.33 3.87e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00114383 chr16:28962172 NFATC2IP -0.52 -6.26 -0.36 1.52e-9 Gut microbiome composition (summer); CESC cis rs2197308 0.765 rs11182992 chr12:37935572 G/C cg26384229 chr12:38710491 ALG10B 0.75 11.15 0.57 6.28e-24 Morning vs. evening chronotype; CESC cis rs9660992 0.710 rs4951184 chr1:205240659 A/T cg00857998 chr1:205179979 DSTYK 0.43 5.03 0.3 9.21e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs933688 1.000 rs2059207 chr5:90731931 C/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.08 13.94 0.65 1.63e-33 Smoking behavior; CESC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg17971929 chr21:40555470 PSMG1 1.06 16.48 0.71 1.79e-42 Cognitive function; CESC cis rs11122272 0.735 rs2011357 chr1:231480208 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -6.41 -0.37 6.56e-10 Hemoglobin concentration; CESC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg21280719 chr6:42927975 GNMT -0.29 -6.47 -0.37 4.76e-10 Alzheimer's disease in APOE e4+ carriers; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07274998 chr10:126107781 OAT -0.43 -6.25 -0.36 1.67e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.14 -0.35 3e-9 Schizophrenia; CESC trans rs35146811 0.735 rs858505 chr7:99819577 G/A cg13215871 chr17:75784724 NA -0.34 -6.33 -0.36 1.07e-9 Coronary artery disease; CESC cis rs7937682 0.847 rs11213948 chr11:111464401 G/A cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC cis rs6076065 0.748 rs2236023 chr20:23373043 A/C cg11657817 chr20:23433608 CST11 0.4 6.11 0.35 3.46e-9 Facial morphology (factor 15, philtrum width); CESC cis rs4523957 0.928 rs12453323 chr17:2160214 T/C cg16513277 chr17:2031491 SMG6 0.6 8.18 0.45 1.22e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs3749237 0.964 rs2352967 chr3:49871641 C/T cg21659725 chr3:3221576 CRBN 0.54 6.4 0.37 7.12e-10 Resting heart rate; CESC cis rs3617 0.625 rs7652667 chr3:52866535 C/A cg07507251 chr3:52567010 NT5DC2 -0.32 -5.43 -0.32 1.27e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs2710642 0.721 rs1038572 chr2:62902019 G/T cg17519650 chr2:63277830 OTX1 0.58 6.88 0.39 4.23e-11 LDL cholesterol levels;LDL cholesterol; CESC cis rs7264396 0.790 rs6121020 chr20:34252006 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.81 0.43 1.36e-13 Total cholesterol levels; CESC cis rs6570726 0.935 rs422540 chr6:145837815 G/T cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs10411161 0.702 rs8113768 chr19:52383938 C/T cg22319618 chr22:45562946 NUP50 -0.7 -6.78 -0.38 7.84e-11 Breast cancer; CESC cis rs829883 0.659 rs11109524 chr12:98939172 G/A cg25150519 chr12:98850993 NA -0.64 -7.87 -0.44 8.8e-14 Colorectal adenoma (advanced); CESC cis rs6493487 0.512 rs8032550 chr15:51178313 A/C cg02338191 chr15:51200825 AP4E1 0.6 5.58 0.32 5.79e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6547741 1.000 rs11127071 chr2:27838058 C/A cg27432699 chr2:27873401 GPN1 0.49 6.93 0.39 3.21e-11 Oral cavity cancer; CESC cis rs2228479 0.717 rs11644967 chr16:89806614 T/A cg06558623 chr16:89946397 TCF25 0.81 7.38 0.41 2e-12 Skin colour saturation; CESC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg17650747 chr5:1873721 NA 0.44 6.06 0.35 4.62e-9 Cardiovascular disease risk factors; CESC cis rs10870270 0.957 rs3829156 chr10:133789386 C/G cg17892150 chr10:133769511 PPP2R2D -0.84 -12.23 -0.6 1.43e-27 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7264396 0.561 rs6142474 chr20:34574914 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.63 6.97 0.39 2.45e-11 Total cholesterol levels; CESC cis rs7818688 0.614 rs60171840 chr8:95832520 C/A cg16049864 chr8:95962084 TP53INP1 0.55 5.64 0.33 4.28e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs6460942 0.597 rs17544637 chr7:12521871 T/C cg06484146 chr7:12443880 VWDE -0.64 -7.13 -0.4 9.4e-12 Coronary artery disease; CESC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.55 0.64 3.83e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9303401 0.538 rs35454383 chr17:56475599 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 9.33 0.5 4.31e-18 Cognitive test performance; CESC cis rs2070488 0.775 rs2070489 chr3:38519424 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.8 12.57 0.61 1.01e-28 Electrocardiographic conduction measures; CESC cis rs7923609 0.967 rs7082470 chr10:65277026 G/A cg01631684 chr10:65280961 REEP3 -0.44 -5.47 -0.32 1.05e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs6547741 1.000 rs6718128 chr2:27833752 A/G cg27432699 chr2:27873401 GPN1 -0.48 -6.83 -0.39 5.64e-11 Oral cavity cancer; CESC cis rs75887402 0.744 rs2303720 chr5:122682334 A/G cg27033705 chr5:122759302 CEP120 -0.84 -6.36 -0.36 8.95e-10 Breast cancer; CESC cis rs2985684 1.000 rs2147712 chr14:50091684 G/A cg02151108 chr14:50098012 C14orf104 -0.45 -5.85 -0.34 1.43e-8 Carotid intima media thickness; CESC cis rs910316 0.737 rs108622 chr14:75481908 A/G cg11812906 chr14:75593930 NEK9 -0.81 -13.05 -0.63 2.11e-30 Height; CESC cis rs208515 0.525 rs12193034 chr6:66677866 C/T cg07460842 chr6:66804631 NA 0.86 10.87 0.56 5.19e-23 Exhaled nitric oxide levels; CESC cis rs1878931 0.559 rs1968055 chr16:3392053 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.71 8.92 0.48 7.73e-17 Body mass index (adult); CESC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg23161317 chr6:28129485 ZNF389 0.49 6.19 0.36 2.28e-9 Parkinson's disease; CESC cis rs8099014 0.906 rs4940695 chr18:56106483 T/G cg19312305 chr18:56117016 MIR122 -0.29 -5.58 -0.32 6.08e-8 Platelet count; CESC cis rs9596863 0.950 rs1379827 chr13:54395414 A/C ch.13.53330881F chr13:54432880 NA 0.66 5.36 0.31 1.84e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC trans rs17227506 0.538 rs71522360 chr8:13463811 A/G cg19797304 chr14:24732234 TGM1 -0.4 -6.23 -0.36 1.78e-9 Nonsyndromic cleft lip with cleft palate; CESC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg27170947 chr2:26402098 FAM59B -0.87 -10.16 -0.53 1.05e-20 Gut microbiome composition (summer); CESC cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg23711669 chr6:146136114 FBXO30 0.92 12.35 0.6 5.59e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs10788264 0.504 rs4751886 chr10:124020396 T/C cg09507567 chr10:124027408 NA 0.42 5.73 0.33 2.77e-8 Total body bone mineral density; CESC cis rs807669 0.548 rs885978 chr22:19198226 A/G cg02655711 chr22:19163373 SLC25A1 0.79 11.96 0.59 1.24e-26 Metabolite levels; CESC trans rs113577745 0.673 rs17364519 chr2:10142819 A/G cg12379383 chr15:96896940 NA -0.59 -6.11 -0.35 3.53e-9 Breast cancer; CESC trans rs9858542 0.953 rs7623659 chr3:49414791 C/T cg21659725 chr3:3221576 CRBN -0.54 -6.47 -0.37 4.62e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7617773 0.817 rs34225441 chr3:48308891 T/A cg11946769 chr3:48343235 NME6 0.87 11.65 0.58 1.3e-25 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19275838 chr7:45115588 CCM2 0.48 6.42 0.37 6.17e-10 Fibrinogen levels; CESC cis rs11785400 1.000 rs13265663 chr8:143732255 A/C cg10596483 chr8:143751796 JRK 0.41 5.39 0.31 1.56e-7 Schizophrenia; CESC cis rs6912958 0.547 rs451089 chr6:88041859 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.74 11.37 0.57 1.18e-24 Monocyte percentage of white cells; CESC cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.22 0.31 3.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs60843830 1.000 rs3828165 chr2:220889 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.88 11.57 0.58 2.48e-25 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1865721 1.000 rs8091890 chr18:73197242 T/C cg26385618 chr18:73139727 C18orf62 -0.51 -7.54 -0.42 7.49e-13 Intelligence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02532014 chr15:85114169 UBE2QP1 -0.54 -6.42 -0.37 6.25e-10 Gut microbiome composition (summer); CESC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.57 0.32 6.32e-8 Personality dimensions; CESC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg04772025 chr11:68637568 NA 0.53 6.44 0.37 5.59e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4243830 0.850 rs10779787 chr1:6599755 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.86 -7.53 -0.42 7.77e-13 Body mass index; CESC cis rs6460942 0.818 rs73299043 chr7:12251595 C/G cg20607287 chr7:12443886 VWDE -0.54 -5.53 -0.32 7.51e-8 Coronary artery disease; CESC cis rs12291225 0.585 rs10832246 chr11:14380828 G/A cg19336497 chr11:14380999 RRAS2 -0.45 -6.59 -0.38 2.32e-10 Sense of smell; CESC cis rs7937682 0.921 rs12806479 chr11:111443192 G/C cg22437258 chr11:111473054 SIK2 -0.66 -7.16 -0.4 7.79e-12 Primary sclerosing cholangitis; CESC cis rs1975974 0.539 rs58796614 chr17:21733767 C/T cg18423549 chr17:21743878 NA -0.61 -8.75 -0.47 2.48e-16 Psoriasis; CESC cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4700695 0.719 rs27084 chr5:65435286 G/A cg21114390 chr5:65439923 SFRS12 -0.48 -5.74 -0.33 2.54e-8 Facial morphology (factor 19); CESC cis rs654950 0.934 rs665223 chr1:42000654 A/T cg06885757 chr1:42089581 HIVEP3 -0.64 -10.2 -0.53 7.82e-21 Airway imaging phenotypes; CESC cis rs10206020 0.921 rs4072986 chr2:1547734 C/G cg26248373 chr2:1572462 NA -0.58 -6.59 -0.38 2.38e-10 IgG glycosylation; CESC cis rs7044106 0.762 rs1886337 chr9:123443776 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 12.82 0.62 1.3e-29 Hip circumference adjusted for BMI; CESC cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg11752832 chr7:134001865 SLC35B4 0.51 6.56 0.37 2.87e-10 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22393360 chr14:81902974 NA 0.58 6.27 0.36 1.42e-9 Gut microbiome composition (summer); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg24722365 chr1:10270654 KIF1B -0.46 -6.24 -0.36 1.75e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC cis rs9287719 0.967 rs7566767 chr2:10754663 T/C cg00105475 chr2:10696890 NA 0.38 5.4 0.31 1.5e-7 Prostate cancer; CESC cis rs9595066 0.715 rs9567366 chr13:44682973 A/C cg04068111 chr13:44716778 NA 0.39 5.56 0.32 6.71e-8 Schizophrenia; CESC cis rs2439831 0.867 rs2260160 chr15:43895643 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.78 8.59 0.47 7.41e-16 Lung cancer in ever smokers; CESC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg13393036 chr8:95962371 TP53INP1 -0.52 -11.64 -0.58 1.41e-25 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27612744 chr5:16465883 ZNF622 0.57 6.48 0.37 4.58e-10 Gut microbiome composition (summer); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg12951224 chr8:38126910 PPAPDC1B -0.47 -6.26 -0.36 1.51e-9 Height; CESC cis rs3762637 1.000 rs11932 chr3:122141135 A/G cg24169773 chr3:122142474 KPNA1 0.52 6.38 0.36 7.77e-10 LDL cholesterol levels; CESC cis rs35306767 0.668 rs12784928 chr10:1083617 A/C cg26597838 chr10:835615 NA 0.51 5.4 0.31 1.47e-7 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9611519 0.780 rs1535048 chr22:41684093 C/T cg17376030 chr22:41985996 PMM1 0.47 5.29 0.31 2.61e-7 Neuroticism; CESC cis rs1559088 0.649 rs4528686 chr19:33556074 A/G cg17764715 chr19:33622953 WDR88 0.46 5.73 0.33 2.7e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg14500267 chr11:67383377 NA -0.31 -5.35 -0.31 1.9e-7 Mean corpuscular volume; CESC cis rs1023500 0.573 rs133378 chr22:42467695 G/C cg04733989 chr22:42467013 NAGA 0.79 12.0 0.59 8.9e-27 Schizophrenia; CESC cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg15485101 chr11:133734466 NA -0.4 -7.09 -0.4 1.21e-11 Childhood ear infection; CESC cis rs9611565 0.546 rs2092274 chr22:42123737 A/G cg17376030 chr22:41985996 PMM1 -0.72 -7.79 -0.43 1.55e-13 Vitiligo; CESC cis rs7762018 0.882 rs4716342 chr6:170137959 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.61 5.87 0.34 1.31e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs3857536 0.813 rs1029399 chr6:66952476 G/C cg07460842 chr6:66804631 NA -0.42 -5.11 -0.3 6.32e-7 Blood trace element (Cu levels); CESC cis rs10751667 0.857 rs6597961 chr11:976677 T/C cg20946044 chr11:1010712 AP2A2 -0.42 -5.6 -0.33 5.23e-8 Alzheimer's disease (late onset); CESC cis rs7149337 0.837 rs4296182 chr14:51662167 A/C cg23942311 chr14:51606299 NA 0.4 6.73 0.38 1.06e-10 Cancer; CESC cis rs2644899 0.750 rs2604869 chr19:41283693 G/A cg24958765 chr19:41283667 RAB4B 0.59 6.56 0.37 2.73e-10 Post bronchodilator FEV1/FVC ratio; CESC cis rs4654899 0.714 rs12123093 chr1:21114416 C/T cg05370193 chr1:21551575 ECE1 0.34 5.05 0.3 8.36e-7 Superior frontal gyrus grey matter volume; CESC cis rs477692 0.583 rs12415589 chr10:131428336 C/G cg26102564 chr10:131424627 MGMT -0.35 -5.22 -0.31 3.59e-7 Response to temozolomide; CESC trans rs2727020 0.530 rs7113153 chr11:49457957 G/A cg03929089 chr4:120376271 NA -0.67 -7.52 -0.42 8.71e-13 Coronary artery disease; CESC cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2865126 0.743 rs1941551 chr18:10744620 G/T cg21165219 chr18:10698044 FAM38B -0.52 -5.42 -0.32 1.31e-7 Metabolite levels (5-HIAA/ MHPG Ratio); CESC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg10800226 chr5:1850261 NA 0.36 5.9 0.34 1.13e-8 Cardiovascular disease risk factors; CESC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg10691866 chr7:65817282 TPST1 0.31 5.37 0.31 1.75e-7 Aortic root size; CESC cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg02487422 chr3:49467188 NICN1 0.46 5.74 0.33 2.54e-8 Parkinson's disease; CESC cis rs11723261 0.582 rs7679573 chr4:151605 G/C cg12746427 chr4:53362 ZNF718;ZNF595 0.47 6.15 0.35 2.91e-9 Immune response to smallpox vaccine (IL-6); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02896403 chr1:155231989 SCAMP3 -0.48 -6.52 -0.37 3.6e-10 Fibrinogen levels; CESC cis rs7789940 0.951 rs73140055 chr7:75975777 A/T cg10167463 chr7:75959203 YWHAG -0.54 -6.8 -0.39 6.91e-11 Multiple sclerosis; CESC cis rs12200560 0.505 rs984520 chr6:97076454 A/G cg06623918 chr6:96969491 KIAA0776 -0.49 -6.22 -0.36 1.89e-9 Coronary heart disease; CESC cis rs919433 1.000 rs112572902 chr2:198175179 G/C cg03934865 chr2:198174659 NA -0.48 -7.4 -0.41 1.83e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg17308151 chr11:8703888 RPL27A -0.54 -6.02 -0.35 5.81e-9 Subjective well-being; CESC cis rs1005277 0.505 rs7069702 chr10:38247359 G/T cg00409905 chr10:38381863 ZNF37A 0.57 8.02 0.44 3.47e-14 Extrinsic epigenetic age acceleration; CESC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg26441486 chr22:50317300 CRELD2 0.42 5.24 0.31 3.33e-7 Schizophrenia; CESC cis rs9457247 1.000 rs405553 chr6:167395058 A/G cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs2731664 0.792 rs465670 chr5:176877624 C/T cg23176889 chr5:176863531 GRK6 -0.63 -11.03 -0.56 1.52e-23 Intelligence (multi-trait analysis); CESC trans rs11992162 0.597 rs6996342 chr8:11784541 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -6.08 -0.35 4.21e-9 Monocyte count; CESC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.47 -5.78 -0.33 2.1e-8 Bipolar disorder; CESC cis rs2204008 0.689 rs1581357 chr12:38391479 C/G cg13010199 chr12:38710504 ALG10B 0.47 5.91 0.34 1.03e-8 Bladder cancer; CESC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg02951883 chr7:2050386 MAD1L1 -0.45 -5.81 -0.34 1.77e-8 Schizophrenia; CESC cis rs748404 0.631 rs560191 chr15:43767774 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.5 0.42 9.94e-13 Lung cancer; CESC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.6 0.47 6.99e-16 Menopause (age at onset); CESC cis rs8062405 1.000 rs62036616 chr16:28826307 A/G cg08761264 chr16:28874980 SH2B1 -0.43 -5.31 -0.31 2.32e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg07395648 chr5:131743802 NA -0.4 -5.16 -0.3 4.79e-7 Blood metabolite levels; CESC cis rs9549260 0.569 rs117615233 chr13:41309223 G/A cg21288729 chr13:41239152 FOXO1 0.58 5.26 0.31 2.92e-7 Red blood cell count; CESC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg14558114 chr2:88469736 THNSL2 -0.43 -6.17 -0.35 2.54e-9 Response to metformin (IC50); CESC cis rs589448 0.902 rs315134 chr12:69762713 G/A cg20891283 chr12:69753455 YEATS4 0.98 16.88 0.72 6.73e-44 Cerebrospinal fluid biomarker levels; CESC cis rs7666738 0.830 rs13148324 chr4:98833616 G/A cg17366294 chr4:99064904 C4orf37 0.54 7.42 0.41 1.61e-12 Colonoscopy-negative controls vs population controls; CESC cis rs8027181 0.839 rs7176235 chr15:72999104 A/G cg25632853 chr15:73088954 NA 0.3 5.26 0.31 3.04e-7 Triglyceride levels; CESC cis rs3733585 0.673 rs6814664 chr4:9956228 C/T cg02734326 chr4:10020555 SLC2A9 -0.41 -5.87 -0.34 1.32e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.13 -0.35 3.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs524281 0.861 rs471484 chr11:65955144 A/G cg14036092 chr11:66035641 RAB1B -0.49 -5.5 -0.32 9.06e-8 Electroencephalogram traits; CESC cis rs921968 0.541 rs58650092 chr2:219304851 C/A cg02176678 chr2:219576539 TTLL4 -0.47 -8.22 -0.45 9.4e-15 Mean corpuscular hemoglobin concentration; CESC cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg15556689 chr8:8085844 FLJ10661 0.49 6.09 0.35 3.93e-9 Mood instability; CESC cis rs10129255 0.500 rs1974468 chr14:107142166 A/G cg07470598 chr14:107239068 NA 0.38 5.42 0.32 1.34e-7 Kawasaki disease; CESC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg12641515 chr19:46296257 DMWD 0.81 10.79 0.55 9.66e-23 Coronary artery disease; CESC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg08470875 chr2:26401718 FAM59B 0.67 6.99 0.39 2.28e-11 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09287164 chr2:220462681 STK11IP -0.45 -6.57 -0.37 2.61e-10 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00995584 chr10:75757877 VCL 0.55 6.21 0.36 2.04e-9 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.79 10.32 0.54 3.26e-21 Height; CESC cis rs72781680 1.000 rs72796357 chr2:24160131 A/G cg20701182 chr2:24300061 SF3B14 0.66 5.88 0.34 1.25e-8 Lymphocyte counts; CESC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.32 5.82 0.34 1.72e-8 Electroencephalogram traits; CESC cis rs7584330 0.910 rs12465081 chr2:238401784 A/G cg14458575 chr2:238380390 NA 0.55 8.1 0.45 1.99e-14 Prostate cancer; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg03771185 chr4:775700 NA -0.48 -6.19 -0.36 2.24e-9 Height; CESC cis rs9790314 0.936 rs336572 chr3:161068014 G/A cg03342759 chr3:160939853 NMD3 -0.42 -5.65 -0.33 4.08e-8 Morning vs. evening chronotype; CESC cis rs832540 0.931 rs832534 chr5:56213672 G/A cg14703610 chr5:56206110 C5orf35 0.55 7.24 0.41 4.82e-12 Coronary artery disease; CESC cis rs910316 0.712 rs175074 chr14:75504454 G/A cg16144293 chr14:75469539 EIF2B2 0.4 5.36 0.31 1.8e-7 Height; CESC cis rs34779708 0.966 rs12782948 chr10:35450607 G/A cg04310649 chr10:35416472 CREM -0.55 -6.85 -0.39 5.16e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs72781680 0.716 rs2675363 chr2:24080003 G/C cg08917208 chr2:24149416 ATAD2B 0.54 5.49 0.32 9.3e-8 Lymphocyte counts; CESC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.17e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4474465 0.920 rs12222907 chr11:78219726 C/T cg27205649 chr11:78285834 NARS2 0.44 5.28 0.31 2.69e-7 Alzheimer's disease (survival time); CESC cis rs1023500 0.551 rs2854837 chr22:42458481 G/A cg15557168 chr22:42548783 NA -0.4 -5.56 -0.32 6.75e-8 Schizophrenia; CESC cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg22862634 chr11:62369728 EML3;MTA2 0.59 8.25 0.45 7.72e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs7267979 1.000 rs6037121 chr20:25428311 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 3e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg21963583 chr11:68658836 MRPL21 0.39 5.66 0.33 3.86e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18342900 chr16:46865048 C16orf87 0.49 6.28 0.36 1.39e-9 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10132348 chr4:6784379 KIAA0232 0.67 7.9 0.44 7.63e-14 Gut microbiome composition (summer); CESC cis rs11711311 0.822 rs9850256 chr3:113408382 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 6.68 0.38 1.42e-10 IgG glycosylation; CESC trans rs9949291 0.565 rs60236554 chr18:61362259 A/G cg18704691 chr1:221052468 HLX -0.39 -6.11 -0.35 3.46e-9 Eosinophil percentage of white cells; CESC trans rs7819412 0.594 rs7460507 chr8:10969075 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.22 -0.36 1.95e-9 Triglycerides; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16701105 chr15:66084815 DENND4A -0.47 -6.17 -0.35 2.51e-9 Asthma; CESC cis rs8060686 0.623 rs255049 chr16:68013471 T/C cg26727032 chr16:67993705 SLC12A4 -0.58 -8.27 -0.45 6.54e-15 HDL cholesterol;Metabolic syndrome; CESC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg22535103 chr8:58192502 C8orf71 -0.92 -10.16 -0.53 1.04e-20 Developmental language disorder (linguistic errors); CESC cis rs950776 0.518 rs12594391 chr15:78816240 A/G cg24631222 chr15:78858424 CHRNA5 -0.4 -5.18 -0.3 4.45e-7 Sudden cardiac arrest; CESC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg07507251 chr3:52567010 NT5DC2 0.4 6.98 0.39 2.43e-11 Bipolar disorder; CESC cis rs35110281 0.548 rs2838350 chr21:45109972 T/C cg01579765 chr21:45077557 HSF2BP -0.51 -8.4 -0.46 2.7e-15 Mean corpuscular volume; CESC cis rs6460942 0.591 rs7800823 chr7:12378697 G/T cg02935154 chr7:12443704 VWDE -0.4 -5.99 -0.35 6.76e-9 Coronary artery disease; CESC cis rs9487051 1.000 rs1341271 chr6:109617542 A/T cg01475377 chr6:109611718 NA -0.42 -6.43 -0.37 6e-10 Reticulocyte fraction of red cells; CESC cis rs9549367 0.762 rs9549694 chr13:113870510 G/A cg00898013 chr13:113819073 PROZ -0.53 -7.88 -0.44 8.46e-14 Platelet distribution width; CESC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg14298792 chr15:30685198 CHRFAM7A 0.46 5.59 0.33 5.51e-8 Huntington's disease progression; CESC cis rs965469 0.779 rs6037571 chr20:3334322 C/T cg17110299 chr20:3385021 C20orf194 0.4 5.24 0.31 3.22e-7 IFN-related cytopenia; CESC cis rs4764487 0.735 rs2159521 chr12:6349328 A/G cg08284733 chr12:6341482 CD9 0.42 6.17 0.35 2.54e-9 Mean platelet volume; CESC cis rs8044868 0.541 rs7202268 chr16:72086746 A/G cg16558253 chr16:72132732 DHX38 -0.41 -6.4 -0.37 7.21e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs9522267 0.535 rs9522302 chr13:112236874 C/T cg10483660 chr13:112241077 NA -0.33 -5.78 -0.33 2.14e-8 Hepatitis; CESC cis rs1707322 1.000 rs10890375 chr1:46406581 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9300255 0.537 rs2695482 chr12:123623174 C/T cg00376283 chr12:123451042 ABCB9 0.7 8.58 0.47 8.2e-16 Neutrophil percentage of white cells; CESC cis rs11048434 0.649 rs11613650 chr12:9060396 T/C cg23795048 chr12:9217529 LOC144571 0.36 5.69 0.33 3.32e-8 Sjögren's syndrome; CESC cis rs8067354 0.645 rs56236317 chr17:57822125 C/T cg02344993 chr17:57696989 CLTC 0.68 8.07 0.44 2.5e-14 Hemoglobin concentration; CESC cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg05347473 chr6:146136440 FBXO30 0.58 7.43 0.42 1.48e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6460942 0.915 rs62447642 chr7:12489147 T/C cg06484146 chr7:12443880 VWDE -0.77 -8.63 -0.47 5.59e-16 Coronary artery disease; CESC cis rs9768139 0.903 rs28503558 chr7:158119568 C/T cg25566285 chr7:158114605 PTPRN2 -0.52 -8.82 -0.48 1.51e-16 Calcium levels; CESC cis rs2204008 0.689 rs1581357 chr12:38391479 C/G cg26384229 chr12:38710491 ALG10B 0.72 10.54 0.54 6.34e-22 Bladder cancer; CESC cis rs1707322 0.691 rs61784803 chr1:46179271 C/A cg03146154 chr1:46216737 IPP -0.82 -11.54 -0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4979906 1.000 rs7098023 chr10:79449665 A/C cg07817648 chr10:79422355 NA -0.49 -5.8 -0.34 1.88e-8 Mortality in heart failure; CESC cis rs6540559 0.673 rs7525951 chr1:210018306 C/T cg25204440 chr1:209979598 IRF6 -0.53 -5.32 -0.31 2.22e-7 Cleft lip with or without cleft palate; CESC cis rs7296418 0.630 rs7974099 chr12:123771475 A/G cg00376283 chr12:123451042 ABCB9 0.59 7.94 0.44 5.64e-14 Platelet count; CESC cis rs116095464 0.558 rs2288458 chr5:231260 C/T cg10591111 chr5:226296 SDHA -0.51 -6.18 -0.35 2.44e-9 Breast cancer; CESC cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.51 9.05 0.49 3.09e-17 Monocyte percentage of white cells; CESC cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.25 0.31 3.12e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7020830 0.931 rs13295115 chr9:37157964 T/G cg14294708 chr9:37120828 ZCCHC7 1.24 23.33 0.82 3.31e-66 Schizophrenia; CESC cis rs11249608 0.590 rs36051170 chr5:178447971 T/C cg01312482 chr5:178451176 ZNF879 -0.41 -5.63 -0.33 4.59e-8 Pubertal anthropometrics; CESC cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg17376030 chr22:41985996 PMM1 0.68 7.58 0.42 5.82e-13 Vitiligo; CESC cis rs561341 1.000 rs554078 chr17:30330109 A/C cg12193833 chr17:30244370 NA -0.76 -6.98 -0.39 2.3e-11 Hip circumference adjusted for BMI; CESC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg06028808 chr11:68637592 NA 0.43 5.12 0.3 5.87e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs752092 0.894 rs8036083 chr15:101767822 T/G cg19997662 chr15:101784653 CHSY1 -0.42 -5.68 -0.33 3.58e-8 Corneal structure; CESC cis rs4891159 0.660 rs4891160 chr18:74102135 C/T cg24786174 chr18:74118243 ZNF516 0.66 10.28 0.53 4.41e-21 Longevity; CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg22907277 chr7:1156413 C7orf50 0.43 6.04 0.35 5.09e-9 Longevity;Endometriosis; CESC cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.42 -0.32 1.37e-7 Developmental language disorder (linguistic errors); CESC cis rs919433 0.783 rs788011 chr2:198230771 A/G cg03934865 chr2:198174659 NA 0.43 6.21 0.36 2.01e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs637571 0.522 rs550435 chr11:65732651 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 10.63 0.55 3.36e-22 Eosinophil percentage of white cells; CESC cis rs734999 0.505 rs10910108 chr1:2539532 A/G cg18854424 chr1:2615690 NA 0.29 5.87 0.34 1.29e-8 Ulcerative colitis; CESC cis rs67460515 0.500 rs9832109 chr3:160723364 T/C cg03342759 chr3:160939853 NMD3 -0.43 -5.4 -0.32 1.45e-7 Parkinson's disease; CESC cis rs933688 1.000 rs6867091 chr5:90734333 C/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.84 11.02 0.56 1.72e-23 Smoking behavior; CESC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.74 0.55 1.38e-22 Height; CESC cis rs4728302 0.869 rs10231102 chr7:133573310 G/A cg10665199 chr7:133106180 EXOC4 0.39 5.36 0.31 1.84e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs854765 0.964 rs854810 chr17:18006421 G/C cg09796270 chr17:17721594 SREBF1 -0.38 -5.13 -0.3 5.62e-7 Total body bone mineral density; CESC cis rs67311347 0.956 rs9822870 chr3:40514890 A/C cg09455208 chr3:40491958 NA -0.48 -8.23 -0.45 8.51e-15 Renal cell carcinoma; CESC cis rs4268898 0.636 rs72787385 chr2:24585820 G/A cg06627628 chr2:24431161 ITSN2 -1.03 -11.63 -0.58 1.53e-25 Asthma; CESC cis rs9303401 0.659 rs35928756 chr17:56702652 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.04 13.0 0.62 3.27e-30 Cognitive test performance; CESC cis rs1707322 1.000 rs10890375 chr1:46406581 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6967414 0.681 rs2881352 chr7:6753511 T/A cg00387323 chr7:6746715 ZNF12 0.65 6.12 0.35 3.39e-9 Hematocrit;Hemoglobin concentration; CESC cis rs9302635 0.513 rs8061282 chr16:72155938 C/T cg01557791 chr16:72042693 DHODH -0.57 -6.65 -0.38 1.66e-10 Blood protein levels; CESC cis rs9400271 0.609 rs9386782 chr6:109588643 G/T cg01475377 chr6:109611718 NA -0.46 -7.18 -0.4 7.24e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs8180040 0.739 rs12488225 chr3:47235107 G/A cg27129171 chr3:47204927 SETD2 0.68 10.33 0.54 3.02e-21 Colorectal cancer; CESC cis rs7666738 0.546 rs10026181 chr4:98814118 C/T cg17366294 chr4:99064904 C4orf37 -0.46 -5.52 -0.32 8.01e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7312933 0.501 rs7296357 chr12:42729891 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.49 -6.37 -0.36 8.5e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs11098499 0.820 rs28394116 chr4:120524283 T/G cg09307838 chr4:120376055 NA 0.88 12.11 0.6 3.6e-27 Corneal astigmatism; CESC cis rs4835473 0.932 rs1375987 chr4:144700775 G/C cg25736465 chr4:144833511 NA -0.33 -5.23 -0.31 3.48e-7 Immature fraction of reticulocytes; CESC cis rs9811920 0.742 rs2316263 chr3:99900096 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.38 5.95 0.34 8.5e-9 Axial length; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25622317 chr11:1002295 AP2A2 0.4 6.24 0.36 1.71e-9 Fibrinogen levels; CESC cis rs4964805 0.526 rs934845 chr12:104185257 T/G cg02344784 chr12:104178138 NT5DC3 0.48 6.91 0.39 3.55e-11 Attention deficit hyperactivity disorder; CESC cis rs9914988 0.943 rs4262997 chr17:27129562 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs7130144 0.541 rs57898590 chr11:130462913 G/A cg26307797 chr11:130446613 NA -0.74 -6.5 -0.37 3.95e-10 Urate levels in lean individuals; CESC cis rs2625529 0.529 rs7183055 chr15:72377048 C/T cg16672083 chr15:72433130 SENP8 0.46 7.12 0.4 1.03e-11 Red blood cell count; CESC trans rs10009321 1.000 rs4525996 chr4:130246216 C/G cg05721189 chr3:14308081 NA -0.48 -6.04 -0.35 5.25e-9 Neurofibrillary tangles; CESC cis rs684232 0.602 rs416662 chr17:535699 A/G cg12384639 chr17:618140 VPS53 0.41 5.28 0.31 2.7e-7 Prostate cancer; CESC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.93e-12 Total body bone mineral density; CESC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg14829155 chr15:31115871 NA 0.74 10.59 0.55 4.45e-22 Huntington's disease progression; CESC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg05863683 chr7:1912471 MAD1L1 0.38 5.54 0.32 7.31e-8 Bipolar disorder and schizophrenia; CESC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg04369109 chr6:150039330 LATS1 -0.39 -5.34 -0.31 2.01e-7 Lung cancer; CESC cis rs897984 0.572 rs112906665 chr16:31040139 T/C cg00531865 chr16:30841666 NA -0.38 -5.36 -0.31 1.84e-7 Dementia with Lewy bodies; CESC cis rs1152591 1.000 rs2738413 chr14:64679960 A/G cg21174375 chr14:64681225 SYNE2 0.46 6.23 0.36 1.84e-9 Atrial fibrillation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22032789 chr5:149512529 PDGFRB -0.38 -6.0 -0.35 6.54e-9 Gambling; CESC cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg27165867 chr14:105738592 BRF1 -0.55 -6.22 -0.36 1.98e-9 Mean platelet volume;Platelet distribution width; CESC cis rs9790314 0.791 rs6809256 chr3:161026513 G/A cg03342759 chr3:160939853 NMD3 -0.51 -7.32 -0.41 2.89e-12 Morning vs. evening chronotype; CESC trans rs9467711 0.606 rs9379863 chr6:26372427 A/G cg06606381 chr12:133084897 FBRSL1 -0.76 -6.89 -0.39 4.1e-11 Autism spectrum disorder or schizophrenia; CESC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.99 10.2 0.53 8.22e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs837841 0.864 rs1660903 chr2:130046679 C/G cg26516701 chr12:53845683 PCBP2 -0.55 -7.06 -0.4 1.44e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg14926445 chr8:58193284 C8orf71 -0.53 -5.04 -0.3 8.54e-7 Developmental language disorder (linguistic errors); CESC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg02711726 chr17:80685570 FN3KRP -0.44 -5.73 -0.33 2.72e-8 Glycated hemoglobin levels; CESC cis rs778371 0.958 rs2675968 chr2:233736244 A/G cg08000102 chr2:233561755 GIGYF2 0.82 13.33 0.63 2.3e-31 Schizophrenia; CESC cis rs116095464 0.614 rs62344339 chr5:252995 T/G cg22857025 chr5:266934 NA -1.29 -18.21 -0.75 1.29e-48 Breast cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04580897 chr3:39448698 SNORA6;RPSA -0.47 -6.28 -0.36 1.36e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2635047 0.566 rs8092050 chr18:44796323 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.07 0.3 7.35e-7 Educational attainment; CESC cis rs2415984 0.622 rs12437018 chr14:46937149 A/G cg14871534 chr14:47121158 RPL10L -0.34 -5.17 -0.3 4.55e-7 Number of children ever born; CESC cis rs6748734 1.000 rs4344931 chr2:241818527 A/C cg07537917 chr2:241836409 C2orf54 -0.25 -5.36 -0.31 1.84e-7 Urinary metabolites; CESC cis rs2274273 1.000 rs7140872 chr14:55612744 C/T cg04306507 chr14:55594613 LGALS3 0.28 5.26 0.31 2.94e-7 Protein biomarker; CESC cis rs3806843 0.832 rs2531360 chr5:140116664 G/A cg26395211 chr5:140044315 WDR55 0.44 5.79 0.33 2.02e-8 Depressive symptoms (multi-trait analysis); CESC cis rs2072438 0.503 rs4837810 chr9:123881199 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.44 0.32 1.19e-7 Rheumatoid arthritis; CESC trans rs2727020 0.894 rs1917328 chr11:49359606 G/A cg03929089 chr4:120376271 NA -0.64 -7.48 -0.42 1.13e-12 Coronary artery disease; CESC cis rs2282802 0.660 rs6873248 chr5:139683762 A/G cg26211634 chr5:139558579 C5orf32 -0.48 -7.0 -0.39 2.14e-11 Intelligence (multi-trait analysis); CESC cis rs13256369 0.802 rs13280101 chr8:8562773 G/A cg00074818 chr8:8560427 CLDN23 0.36 5.17 0.3 4.58e-7 Obesity-related traits; CESC cis rs13242816 1.000 rs62471184 chr7:116090300 G/A cg04696780 chr7:116139425 CAV2 -0.63 -5.64 -0.33 4.39e-8 P wave duration; CESC cis rs4253772 0.591 rs11705624 chr22:46685380 C/T cg10541313 chr22:46663664 TTC38 0.72 5.15 0.3 5.01e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7772486 0.790 rs9376970 chr6:146241472 A/C cg05347473 chr6:146136440 FBXO30 -0.56 -7.4 -0.41 1.82e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1401999 0.966 rs2139560 chr3:183653869 A/G cg01324343 chr3:183735012 ABCC5 0.66 14.04 0.65 7.57e-34 Anterior chamber depth; CESC cis rs3026101 0.671 rs8077472 chr17:5299359 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg11764359 chr7:65958608 NA -0.53 -7.1 -0.4 1.13e-11 Aortic root size; CESC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg23743428 chr13:21893420 NA -0.38 -6.1 -0.35 3.69e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2901656 0.677 rs2269615 chr1:172415451 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.52 8.0 0.44 3.88e-14 Red cell distribution width;Platelet distribution width; CESC cis rs10779751 1.000 rs2300094 chr1:11266044 C/T cg08854313 chr1:11322531 MTOR 0.91 14.32 0.66 7.99e-35 Body mass index; CESC cis rs714031 0.934 rs2235342 chr22:40068853 T/C cg21377881 chr22:40064566 CACNA1I -0.32 -5.16 -0.3 4.96e-7 Schizophrenia; CESC cis rs7605827 0.897 rs6734288 chr2:15526222 T/G cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02250553 chr10:134511404 INPP5A 0.49 6.47 0.37 4.78e-10 Fibrinogen levels; CESC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg04369109 chr6:150039330 LATS1 -0.4 -5.47 -0.32 1.04e-7 Lung cancer; CESC cis rs10979 1.000 rs9403504 chr6:143885430 G/A cg25407410 chr6:143891975 LOC285740 -0.62 -9.51 -0.5 1.21e-18 Hypospadias; CESC cis rs11608355 0.545 rs7139106 chr12:109908640 G/A cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs4819052 0.580 rs419322 chr21:46551702 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.52 5.6 0.33 5.39e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs13130787 0.802 rs10030952 chr4:94938117 C/T cg11021082 chr4:95130006 SMARCAD1 0.38 5.1 0.3 6.56e-7 Colorectal cancer; CESC cis rs8180040 0.620 rs749511 chr3:47035735 A/C cg27129171 chr3:47204927 SETD2 -0.67 -9.95 -0.52 5.18e-20 Colorectal cancer; CESC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.44 0.32 1.21e-7 Major depressive disorder; CESC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00298675 chr2:73612788 ALMS1 0.57 6.45 0.37 5.4e-10 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.59 7.71 0.43 2.62e-13 Menopause (age at onset); CESC cis rs7589342 0.899 rs10185551 chr2:106492201 A/C cg14210321 chr2:106509881 NCK2 -0.48 -5.61 -0.33 5.2100000000000003e-08 Addiction; CESC cis rs4906332 1.000 rs10459573 chr14:103925457 A/C cg09975044 chr14:104007538 NA 0.47 6.45 0.37 5.25e-10 Coronary artery disease; CESC cis rs6831352 0.918 rs35784540 chr4:100061692 T/A cg12011299 chr4:100065546 ADH4 -0.6 -6.61 -0.38 2.09e-10 Alcohol dependence; CESC cis rs7917772 0.536 rs17783771 chr10:104410736 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.58 7.1 0.4 1.12e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2262909 0.962 rs12609368 chr19:22263996 T/C cg11619707 chr19:22235551 ZNF257 0.34 5.44 0.32 1.24e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs9322193 0.607 rs7764677 chr6:150227333 C/T cg01145232 chr6:150245071 RAET1G 0.51 6.63 0.38 1.88e-10 Lung cancer; CESC cis rs1728785 1.000 rs1645936 chr16:68563743 A/G cg02972257 chr16:68554789 NA -0.49 -5.93 -0.34 9.24e-9 Ulcerative colitis; CESC cis rs72945132 0.882 rs61260732 chr11:70162145 G/A cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs9300255 0.602 rs10846486 chr12:123709927 G/A cg00376283 chr12:123451042 ABCB9 0.7 8.89 0.48 9.66e-17 Neutrophil percentage of white cells; CESC cis rs6426558 0.537 rs7512409 chr1:227484038 A/G cg10327440 chr1:227177885 CDC42BPA -0.41 -5.24 -0.31 3.24e-7 Neutrophil percentage of white cells; CESC cis rs7267979 0.966 rs2257233 chr20:25265984 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.9 -18.45 -0.75 1.86e-49 Liver enzyme levels (alkaline phosphatase); CESC cis rs847577 0.609 rs6465658 chr7:97816638 C/G cg21770322 chr7:97807741 LMTK2 0.83 13.36 0.63 1.74e-31 Breast cancer; CESC cis rs11690935 0.959 rs2674484 chr2:172574612 G/A cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.77 -0.67 2.06e-36 Schizophrenia; CESC cis rs6500395 1.000 rs9931737 chr16:48623539 C/T cg04672837 chr16:48644449 N4BP1 0.52 6.64 0.38 1.81e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9457247 1.000 rs421214 chr6:167396629 A/G cg25258033 chr6:167368657 RNASET2 0.4 5.95 0.34 8.36e-9 Crohn's disease; CESC cis rs7165102 1.000 rs590958 chr15:65735707 T/G cg11441148 chr15:65824328 PTPLAD1 0.33 5.48 0.32 1e-7 Mean corpuscular hemoglobin; CESC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg03188948 chr7:1209495 NA 0.73 7.05 0.4 1.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7772486 0.790 rs9399571 chr6:146282061 A/G cg05347473 chr6:146136440 FBXO30 -0.56 -7.11 -0.4 1.09e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2180341 0.521 rs12203812 chr6:127617816 A/T cg24812749 chr6:127587940 RNF146 0.49 6.36 0.36 8.77e-10 Breast cancer; CESC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg21644426 chr2:191273491 MFSD6 -0.49 -6.68 -0.38 1.42e-10 Pulse pressure; CESC cis rs13336428 0.730 rs28653458 chr16:1525850 T/C cg26690334 chr16:1524521 CLCN7 -0.37 -5.35 -0.31 1.87e-7 Bone mineral density; CESC cis rs12893668 0.703 rs55751606 chr14:104028806 G/A cg08213375 chr14:104286397 PPP1R13B 0.32 5.04 0.3 8.58e-7 Reticulocyte count; CESC cis rs1534166 0.601 rs13324779 chr3:133510413 G/A cg12373951 chr3:133503437 NA -0.35 -5.26 -0.31 2.9e-7 Alcohol consumption (transferrin glycosylation); CESC cis rs12478296 0.685 rs35577962 chr2:242993575 A/G cg06360820 chr2:242988706 NA -0.81 -9.49 -0.5 1.38e-18 Obesity-related traits; CESC cis rs8062405 1.000 rs56358680 chr16:28843118 A/G cg08761264 chr16:28874980 SH2B1 -0.45 -5.67 -0.33 3.78e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs826838 0.967 rs4768329 chr12:39129394 T/C cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg25838465 chr1:92012736 NA 0.6 8.88 0.48 1.07e-16 Breast cancer; CESC trans rs9929218 0.529 rs17715450 chr16:68729785 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.86 13.93 0.65 1.8e-33 Colorectal cancer; CESC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg11366901 chr6:160182831 ACAT2 0.82 10.61 0.55 3.82e-22 Age-related macular degeneration (geographic atrophy); CESC cis rs7927771 1.000 rs7947730 chr11:47786184 C/T cg05585544 chr11:47624801 NA -0.5 -7.88 -0.44 8.28e-14 Subjective well-being; CESC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg02896835 chr1:92012615 NA -0.57 -7.98 -0.44 4.45e-14 Breast cancer; CESC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg01570182 chr17:44337453 NA -0.65 -8.65 -0.47 5.14e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6499255 0.857 rs8060588 chr16:69656500 A/G cg15192750 chr16:69999425 NA 0.51 5.87 0.34 1.33e-8 IgE levels; CESC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg12564285 chr5:131593104 PDLIM4 0.37 5.57 0.32 6.26e-8 Breast cancer; CESC cis rs1364705 1.000 rs13262685 chr8:120226145 A/G cg09273054 chr8:120220131 MAL2 0.5 5.71 0.33 3.05e-8 Hippocampal atrophy; CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.74 0.38 9.81e-11 Bipolar disorder; CESC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg12463550 chr7:65579703 CRCP -0.5 -6.34 -0.36 9.71e-10 Aortic root size; CESC cis rs3008870 1.000 rs12740884 chr1:67459855 C/A cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.19 -0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs4900538 0.787 rs11704 chr14:102808655 C/G cg18135206 chr14:102964638 TECPR2 0.69 8.36 0.46 3.51e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7726839 1.000 rs7726839 chr5:618586 A/G cg03128945 chr5:622914 CEP72 -0.39 -5.29 -0.31 2.59e-7 Obesity-related traits; CESC cis rs10242455 0.702 rs45451992 chr7:99041416 C/A cg18809830 chr7:99032528 PTCD1 -0.93 -5.77 -0.33 2.19e-8 Blood metabolite levels; CESC cis rs11674184 0.525 rs4669755 chr2:11748585 A/C cg07314298 chr2:11723111 GREB1 0.57 8.17 0.45 1.25e-14 Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24531267 chr20:34043122 CEP250 0.62 7.19 0.4 6.5e-12 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16139199 chr18:19180362 ESCO1 0.53 7.85 0.43 1.02e-13 Systemic lupus erythematosus; CESC cis rs4843747 0.708 rs11866437 chr16:88072279 A/G cg06915872 chr16:87998081 BANP -0.45 -5.63 -0.33 4.6e-8 Menopause (age at onset); CESC cis rs9916302 0.904 rs2338797 chr17:37548241 G/A cg15445000 chr17:37608096 MED1 -0.41 -6.75 -0.38 9.08e-11 Glomerular filtration rate (creatinine); CESC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg19622623 chr12:86230825 RASSF9 -0.44 -5.61 -0.33 4.98e-8 Major depressive disorder; CESC cis rs9487051 0.714 rs7744284 chr6:109616218 C/T cg21918786 chr6:109611834 NA -0.38 -5.55 -0.32 6.89e-8 Reticulocyte fraction of red cells; CESC cis rs897984 0.537 rs8045637 chr16:30818662 C/T cg02466173 chr16:30829666 NA -0.6 -11.78 -0.59 4.82e-26 Dementia with Lewy bodies; CESC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg06074448 chr4:187884817 NA -0.37 -5.22 -0.31 3.6e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs4843747 0.636 rs11864872 chr16:88105966 A/G cg06915872 chr16:87998081 BANP 0.44 5.25 0.31 3.11e-7 Menopause (age at onset); CESC cis rs67079557 1 rs67079557 chr15:75930300 ATAATAAG/A cg20655648 chr15:75932815 IMP3 0.53 6.55 0.37 3.06e-10 Breast cancer; CESC cis rs1215050 0.740 rs10025482 chr4:99053277 T/C cg05340658 chr4:99064831 C4orf37 0.61 8.27 0.45 6.57e-15 Waist-to-hip ratio adjusted for body mass index; CESC cis rs10927875 0.965 rs3961710 chr1:16313172 C/T cg21385522 chr1:16154831 NA -0.77 -9.68 -0.51 3.51e-19 Dilated cardiomyopathy; CESC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg10691866 chr7:65817282 TPST1 -0.31 -5.25 -0.31 3.18e-7 Aortic root size; CESC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg04166393 chr7:2884313 GNA12 0.43 5.73 0.33 2.75e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs6088580 0.634 rs4911151 chr20:32932273 T/C cg06115741 chr20:33292138 TP53INP2 -0.44 -5.65 -0.33 4.16e-8 Glomerular filtration rate (creatinine); CESC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.65 9.04 0.49 3.33e-17 Menopause (age at onset); CESC trans rs35110281 0.806 rs1454649 chr21:45032982 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 7.25 0.41 4.58e-12 Mean corpuscular volume; CESC cis rs9399135 0.967 rs9376077 chr6:135299713 C/G cg24558204 chr6:135376177 HBS1L 0.5 6.66 0.38 1.58e-10 Red blood cell count; CESC cis rs8078723 0.738 rs4065321 chr17:38143548 C/T cg17467752 chr17:38218738 THRA -0.56 -8.48 -0.46 1.63e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs6445797 0.632 rs9842283 chr3:56609469 G/T cg13792233 chr3:56591045 CCDC66 0.39 5.13 0.3 5.61e-7 Gastritis; CESC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.49 0.64 6.45e-32 Prudent dietary pattern; CESC cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg01579765 chr21:45077557 HSF2BP -0.54 -9.3 -0.5 5.56e-18 Mean corpuscular volume; CESC cis rs909002 0.849 rs3753611 chr1:32082486 C/T cg13919466 chr1:32135498 COL16A1 -0.46 -8.05 -0.44 2.89e-14 Intelligence (multi-trait analysis); CESC cis rs8114671 0.562 rs1018447 chr20:33401707 A/G cg07148914 chr20:33460835 GGT7 -0.42 -5.64 -0.33 4.29e-8 Height; CESC cis rs4237845 0.537 rs11172369 chr12:58280592 T/C cg02175503 chr12:58329896 NA 0.5 5.92 0.34 9.68e-9 Intelligence (multi-trait analysis); CESC cis rs2806561 0.808 rs4654834 chr1:23364919 T/C cg12483005 chr1:23474871 LUZP1 -0.33 -5.36 -0.31 1.8e-7 Height; CESC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg17747265 chr1:1875780 NA -0.6 -9.81 -0.52 1.42e-19 Body mass index; CESC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg11366901 chr6:160182831 ACAT2 0.76 9.31 0.5 4.95e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs644799 0.930 rs631099 chr11:95563482 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.27 0.66 1.19e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7044106 0.762 rs1886337 chr9:123443776 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.09 0.53 1.84e-20 Hip circumference adjusted for BMI; CESC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg25985355 chr7:65971099 NA -0.32 -5.28 -0.31 2.71e-7 Aortic root size; CESC cis rs2836633 0.929 rs11702165 chr21:40035313 C/T cg05519781 chr21:40033154 ERG 0.79 13.91 0.65 2.1e-33 Coronary artery disease; CESC cis rs365132 0.818 rs6879982 chr5:176351330 A/T cg16309518 chr5:176445507 NA -0.37 -5.39 -0.31 1.59e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs11122272 0.735 rs2749711 chr1:231537543 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.44 -0.42 1.38e-12 Hemoglobin concentration; CESC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg13393036 chr8:95962371 TP53INP1 -0.49 -10.52 -0.54 7.38e-22 Type 2 diabetes; CESC cis rs4919687 0.550 rs11191372 chr10:104462187 T/C cg04362960 chr10:104952993 NT5C2 0.45 5.36 0.31 1.82e-7 Colorectal cancer; CESC cis rs561341 0.883 rs886224 chr17:30229902 T/C cg13647721 chr17:30228624 UTP6 0.59 5.34 0.31 1.99e-7 Hip circumference adjusted for BMI; CESC cis rs7258465 1.000 rs2303695 chr19:18562624 C/T cg25828334 chr19:18545568 ISYNA1 -0.32 -5.16 -0.3 4.81e-7 Breast cancer; CESC cis rs9611565 0.921 rs4822021 chr22:41726053 G/A cg06481639 chr22:41940642 POLR3H -0.59 -6.39 -0.37 7.32e-10 Vitiligo; CESC cis rs6963495 0.818 rs73190155 chr7:105153535 T/A cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs6444746 1.000 rs2008918 chr3:193499512 A/G cg22553634 chr3:193489233 NA -0.47 -5.53 -0.32 7.78e-8 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); CESC cis rs796364 0.625 rs13035260 chr2:201132377 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.49 -5.14 -0.3 5.38e-7 Schizophrenia; CESC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg24060327 chr5:131705240 SLC22A5 0.76 10.57 0.54 5.15e-22 Breast cancer; CESC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24608144 chr20:62398219 ZBTB46 0.58 7.71 0.43 2.55e-13 Fibrinogen levels; CESC cis rs644799 1.000 rs560854 chr11:95584905 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.67 8.18 0.45 1.16e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2243480 1.000 rs13237037 chr7:65997882 T/C cg18252515 chr7:66147081 NA -1.4 -14.3 -0.66 9.38e-35 Diabetic kidney disease; CESC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.41e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7520050 0.807 rs3013595 chr1:46153203 G/A cg24296786 chr1:45957014 TESK2 -0.48 -6.14 -0.35 2.96e-9 Red blood cell count;Reticulocyte count; CESC cis rs11723261 0.582 rs11735742 chr4:142550 C/T cg12746427 chr4:53362 ZNF718;ZNF595 -0.46 -6.0 -0.35 6.48e-9 Immune response to smallpox vaccine (IL-6); CESC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg05552183 chr6:42928497 GNMT 0.8 13.69 0.64 1.23e-32 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg23711669 chr6:146136114 FBXO30 -0.91 -12.26 -0.6 1.1e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27169379 chr21:43274834 PRDM15 -0.6 -6.44 -0.37 5.65e-10 Gut microbiome composition (summer); CESC trans rs4650994 0.525 rs2493858 chr1:178541210 A/G cg05059571 chr16:84539110 KIAA1609 -0.39 -6.01 -0.35 5.99e-9 HDL cholesterol levels;HDL cholesterol; CESC cis rs7267979 1.000 rs4815424 chr20:25390284 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.35 -0.71 4.94e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs36051895 0.664 rs3780371 chr9:5095191 T/A cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.61e-9 Pediatric autoimmune diseases; CESC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg22549504 chr19:17448937 GTPBP3 0.5 5.56 0.32 6.74e-8 Systemic lupus erythematosus; CESC cis rs1971256 0.500 rs9479050 chr6:151806338 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.61 5.62 0.33 4.85e-8 Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26088104 chr5:43515152 C5orf34 -0.53 -6.21 -0.36 2e-9 Gut microbiome composition (summer); CESC cis rs4319547 0.794 rs61954972 chr12:123074167 T/G cg05707623 chr12:122985044 ZCCHC8 -0.58 -6.75 -0.38 9.5e-11 Body mass index; CESC cis rs1387259 0.929 rs2634666 chr12:48663670 G/T cg24011408 chr12:48396354 COL2A1 0.43 6.07 0.35 4.46e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC trans rs60180747 1.000 rs35510028 chr15:66612079 C/G cg01218494 chr17:71160864 SSTR2 0.45 6.03 0.35 5.59e-9 Testicular germ cell tumor; CESC cis rs12438659 1 rs12438659 chr15:78824924 G/A cg24631222 chr15:78858424 CHRNA5 0.76 9.6 0.51 6.48e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7772486 0.875 rs2777483 chr6:146329235 A/G cg05347473 chr6:146136440 FBXO30 0.53 6.96 0.39 2.7e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2540647 0.908 rs2540654 chr22:18973671 C/T cg12798833 chr22:18958832 DGCR5 0.73 7.34 0.41 2.56e-12 Blood metabolite ratios; CESC cis rs34891900 0.507 rs2008085 chr22:18204316 T/G cg19898043 chr22:18121309 BCL2L13 0.57 6.78 0.38 7.99e-11 Sum neutrophil eosinophil counts; CESC cis rs863345 0.584 rs10908676 chr1:158506163 C/G cg12129480 chr1:158549410 OR10X1 -0.33 -6.54 -0.37 3.17e-10 Pneumococcal bacteremia; CESC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg12658694 chr1:38397304 INPP5B -0.61 -7.96 -0.44 5.03e-14 Coronary artery disease; CESC cis rs11098499 0.909 rs71614422 chr4:120359340 G/A cg09307838 chr4:120376055 NA 0.95 13.68 0.64 1.38e-32 Corneal astigmatism; CESC cis rs1801251 1.000 rs12990821 chr2:233617585 C/G cg08000102 chr2:233561755 GIGYF2 0.67 9.48 0.5 1.53e-18 Coronary artery disease; CESC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs2304069 0.545 rs11167492 chr5:149403101 G/A cg12661370 chr5:149340060 SLC26A2 0.43 5.62 0.33 4.77e-8 HIV-1 control; CESC cis rs7659604 0.540 rs11098643 chr4:122701507 C/A cg19671926 chr4:122722719 EXOSC9 0.65 8.61 0.47 6.55e-16 Type 2 diabetes; CESC trans rs4957048 0.891 rs11960196 chr5:568857 C/A cg25482853 chr8:67687455 SGK3 0.97 10.84 0.55 6.55e-23 Ulcerative colitis; CESC cis rs3091242 0.933 rs11249250 chr1:25767609 G/A cg03538708 chr1:25844672 NA -0.39 -5.93 -0.34 9.62e-9 Erythrocyte sedimentation rate; CESC cis rs769267 0.629 rs7245672 chr19:19699963 T/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.42 -5.03 -0.3 9.08e-7 Tonsillectomy; CESC cis rs6502050 0.835 rs4789678 chr17:80101078 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.15 -0.3 5.06e-7 Life satisfaction; CESC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.34 0.41 2.56e-12 Tonsillectomy; CESC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg27266027 chr21:40555129 PSMG1 0.48 5.82 0.34 1.68e-8 Cognitive function; CESC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg04518342 chr5:131593106 PDLIM4 -0.36 -5.05 -0.3 8.21e-7 Blood metabolite levels; CESC cis rs7100689 0.577 rs4934038 chr10:82057334 C/A cg09936400 chr10:82049201 MAT1A 0.4 6.04 0.35 5.32e-9 Post bronchodilator FEV1; CESC cis rs58785573 0.624 rs2126526 chr4:38618689 A/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.41 5.34 0.31 1.96e-7 Lymphocyte percentage of white cells; CESC cis rs9682041 0.825 rs6785326 chr3:170095145 T/C cg11886554 chr3:170076028 SKIL 1.05 8.52 0.46 1.25e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs7116495 1.000 rs2511114 chr11:71792147 T/C cg10381502 chr11:71823885 C11orf51 -0.7 -5.7 -0.33 3.19e-8 Severe influenza A (H1N1) infection; CESC cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg17211192 chr8:82754475 SNX16 -0.7 -8.37 -0.46 3.35e-15 Diastolic blood pressure; CESC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg08859206 chr1:53392774 SCP2 0.56 7.11 0.4 1.1e-11 Monocyte count; CESC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg19717773 chr7:2847554 GNA12 -0.56 -7.94 -0.44 5.68e-14 Height; CESC cis rs854765 0.583 rs4925126 chr17:17798633 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.46 5.93 0.34 9.52e-9 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19413799 chr1:32645788 TXLNA 0.57 6.73 0.38 1.07e-10 Gut microbiome composition (summer); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg14705778 chr4:174254825 HMGB2 0.48 6.29 0.36 1.27e-9 Thyroid stimulating hormone; CESC cis rs748404 0.697 rs555001 chr15:43545728 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.86 0.43 9.6e-14 Lung cancer; CESC cis rs8141529 0.764 rs5752809 chr22:29225500 G/A cg02153584 chr22:29168773 CCDC117 0.64 9.16 0.49 1.46e-17 Lymphocyte counts; CESC cis rs7116495 1.000 rs517837 chr11:71802359 A/G cg26138937 chr11:71823887 C11orf51 -0.86 -7.03 -0.4 1.75e-11 Severe influenza A (H1N1) infection; CESC cis rs614226 0.935 rs7137953 chr12:120894685 C/T cg27489772 chr12:121021490 NA -0.5 -5.1 -0.3 6.48e-7 Type 1 diabetes nephropathy; CESC cis rs6584283 0.875 rs1548962 chr10:101289735 C/G cg09788492 chr10:101292477 NKX2-3 -0.32 -5.86 -0.34 1.35e-8 Ulcerative colitis; CESC cis rs6740322 0.895 rs28456986 chr2:43553321 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.7 -7.43 -0.42 1.52e-12 Coronary artery disease; CESC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg09877947 chr5:131593287 PDLIM4 0.45 5.96 0.34 7.83e-9 Breast cancer; CESC cis rs2239547 0.618 rs4687658 chr3:52860366 C/G cg11645453 chr3:52864694 ITIH4 0.32 5.89 0.34 1.15e-8 Schizophrenia; CESC cis rs72829446 0.530 rs7217492 chr17:7396049 C/G cg02795151 chr17:7402630 POLR2A 0.58 6.04 0.35 5.08e-9 Androgen levels; CESC cis rs6138458 1.000 rs227658 chr20:24932028 A/G cg06937882 chr20:24974362 C20orf3 -0.35 -5.11 -0.3 6.15e-7 Blood protein levels; CESC cis rs61931739 0.571 rs4001689 chr12:34243271 C/T cg19457237 chr12:34500585 NA -0.38 -5.38 -0.31 1.61e-7 Morning vs. evening chronotype; CESC cis rs9581857 0.579 rs3759433 chr13:27997999 C/T cg01674679 chr13:27998804 GTF3A -0.58 -6.05 -0.35 4.82e-9 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg12963246 chr6:28129442 ZNF389 0.54 7.18 0.4 6.92e-12 Depression; CESC cis rs933688 1.000 rs6867219 chr5:90718008 T/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.98 11.78 0.59 5.05e-26 Smoking behavior; CESC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg14393609 chr7:65229607 NA 0.52 6.97 0.39 2.47e-11 Calcium levels; CESC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg09658497 chr7:2847517 GNA12 -0.42 -5.96 -0.34 8.2e-9 Height; CESC cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg26874164 chr19:58962979 ZNF324B 0.52 7.02 0.4 1.81e-11 Uric acid clearance; CESC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 11.04 0.56 1.49e-23 Platelet count; CESC cis rs7246657 0.943 rs7246993 chr19:37890154 C/T cg23950597 chr19:37808831 NA -0.61 -6.19 -0.36 2.31e-9 Coronary artery calcification; CESC cis rs3733585 0.664 rs28602527 chr4:9958327 G/A cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs35110281 0.591 rs86138 chr21:44932398 G/A cg21573476 chr21:45109991 RRP1B -0.39 -5.62 -0.33 4.71e-8 Mean corpuscular volume; CESC cis rs763121 0.853 rs5757181 chr22:39013522 G/A cg06544989 chr22:39130855 UNC84B 0.49 7.99 0.44 4.07e-14 Menopause (age at onset); CESC cis rs3857067 0.967 rs5019896 chr4:95035751 C/T cg11021082 chr4:95130006 SMARCAD1 0.51 7.76 0.43 1.82e-13 QT interval; CESC cis rs965513 0.524 rs6478413 chr9:100582024 A/G cg13688889 chr9:100608707 NA -0.53 -7.69 -0.43 2.87e-13 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs9300255 0.679 rs12817892 chr12:123728702 G/A cg00376283 chr12:123451042 ABCB9 -0.63 -6.54 -0.37 3.21e-10 Neutrophil percentage of white cells; CESC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs9815354 0.857 rs9852020 chr3:41830206 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg12463550 chr7:65579703 CRCP 0.59 7.45 0.42 1.29e-12 Aortic root size; CESC cis rs2072732 0.861 rs66693767 chr1:2955930 A/G cg03976712 chr1:2946727 NA 0.33 5.53 0.32 7.83e-8 Plateletcrit; CESC cis rs7772486 0.727 rs12190966 chr6:146146820 T/G cg23711669 chr6:146136114 FBXO30 0.88 12.62 0.61 6.34e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs1499614 1.000 rs2659903 chr7:66180931 G/A cg18252515 chr7:66147081 NA -1.42 -14.62 -0.67 6.69e-36 Gout; CESC cis rs2996428 0.709 rs12127399 chr1:3721609 G/A cg13057898 chr1:3703894 LRRC47 0.47 6.46 0.37 4.86e-10 Red cell distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05697969 chr19:590413 HCN2 0.51 6.17 0.35 2.59e-9 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02923393 chr16:1543003 TELO2 0.52 6.78 0.38 7.95e-11 Gut microbiota (bacterial taxa); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00575769 chr8:22079255 PHYHIP 0.46 6.06 0.35 4.74e-9 Fibrinogen levels; CESC trans rs6445797 0.821 rs57800049 chr3:56665015 A/T cg15444621 chr13:113611794 NA 0.33 6.15 0.35 2.85e-9 Gastritis; CESC cis rs2204008 0.807 rs4123933 chr12:37973539 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.84 0.55 6.46e-23 Bladder cancer; CESC cis rs6089584 0.566 rs55881457 chr20:60608424 G/A cg06108461 chr20:60628389 TAF4 -0.62 -8.21 -0.45 9.98e-15 Body mass index; CESC cis rs7192750 0.652 rs152828 chr16:72123886 T/C cg14768367 chr16:72042858 DHODH 0.7 5.57 0.32 6.23e-8 LDL cholesterol levels;Total cholesterol levels; CESC cis rs36051895 0.659 rs57204002 chr9:5062610 T/C cg02405213 chr9:5042618 JAK2 -0.49 -5.96 -0.34 7.96e-9 Pediatric autoimmune diseases; CESC cis rs12220238 1.000 rs6480723 chr10:75966366 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.45 0.32 1.13e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs72945132 1.000 rs56913804 chr11:70114673 G/A cg14191688 chr11:70257035 CTTN 0.41 5.04 0.3 8.65e-7 Coronary artery disease; CESC cis rs9911578 0.967 rs7503190 chr17:57184162 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.07 0.3 7.47e-7 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20769334 chr22:50913335 SBF1 -0.44 -6.59 -0.38 2.43e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs60843830 1.000 rs56167434 chr2:282137 G/C cg25945732 chr2:264204 ACP1;SH3YL1 0.87 11.53 0.58 3.43e-25 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs763121 0.853 rs5757213 chr22:39053888 C/T cg14440974 chr22:39074834 NA -0.4 -5.49 -0.32 9.53e-8 Menopause (age at onset); CESC cis rs193541 0.632 rs30023 chr5:122285299 T/G cg19412675 chr5:122181750 SNX24 0.46 5.49 0.32 9.32e-8 Glucose homeostasis traits; CESC cis rs1707322 0.752 rs61784793 chr1:46149285 G/A cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4835473 0.897 rs7657088 chr4:144623030 G/A cg25736465 chr4:144833511 NA -0.35 -5.24 -0.31 3.23e-7 Immature fraction of reticulocytes; CESC cis rs1003719 0.788 rs2835576 chr21:38457393 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.67 0.47 4.41e-16 Eye color traits; CESC cis rs1707322 0.721 rs10749856 chr1:46164846 A/T cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs67311347 0.826 rs9863679 chr3:40439614 G/A cg24209194 chr3:40518798 ZNF619 0.52 6.48 0.37 4.46e-10 Renal cell carcinoma; CESC cis rs3733585 0.699 rs6815001 chr4:9958662 G/C cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9905704 0.918 rs4132924 chr17:56937653 C/T cg12560992 chr17:57184187 TRIM37 0.61 7.05 0.4 1.54e-11 Testicular germ cell tumor; CESC cis rs2573652 1.000 rs2581341 chr15:100514494 T/C cg00587665 chr15:100533223 ADAMTS17 -0.36 -5.65 -0.33 4.06e-8 Height; CESC cis rs763121 0.853 rs5757204 chr22:39046700 A/C cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs832540 0.656 rs702689 chr5:56177443 G/A cg24531977 chr5:56204891 C5orf35 -0.48 -5.88 -0.34 1.26e-8 Coronary artery disease; CESC cis rs7560272 0.538 rs4852972 chr2:73916672 C/T cg20560298 chr2:73613845 ALMS1 0.45 6.14 0.35 3.03e-9 Schizophrenia; CESC cis rs11098499 0.866 rs6824111 chr4:120285968 T/A cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs9611519 0.894 rs4821990 chr22:41438710 A/C cg03806693 chr22:41940476 POLR3H -0.55 -5.82 -0.34 1.65e-8 Neuroticism; CESC cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs858239 0.601 rs6971002 chr7:23172304 C/G cg23682824 chr7:23144976 KLHL7 0.55 7.57 0.42 6.22e-13 Cerebrospinal fluid biomarker levels; CESC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg17509989 chr5:176798049 RGS14 -0.75 -8.4 -0.46 2.71e-15 Hemoglobin concentration;Hematocrit; CESC cis rs3820068 0.581 rs72645888 chr1:15929922 C/A cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs7223966 1.000 rs6504170 chr17:61709168 C/T cg11494091 chr17:61959527 GH2 0.41 5.84 0.34 1.53e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg11890956 chr21:40555474 PSMG1 -0.61 -8.44 -0.46 2.16e-15 Menarche (age at onset); CESC cis rs4268898 0.931 rs60716082 chr2:24526265 T/A cg06627628 chr2:24431161 ITSN2 -0.71 -8.6 -0.47 7.33e-16 Asthma; CESC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.49 6.97 0.39 2.44e-11 Bipolar disorder; CESC cis rs1801251 0.656 rs10211596 chr2:233699415 C/T cg08000102 chr2:233561755 GIGYF2 -0.73 -11.94 -0.59 1.42e-26 Coronary artery disease; CESC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg18016565 chr1:150552671 MCL1 0.33 5.13 0.3 5.67e-7 Tonsillectomy; CESC cis rs400736 0.896 rs225126 chr1:8090615 A/G cg25007680 chr1:8021821 PARK7 0.71 10.05 0.53 2.34e-20 Response to antidepressants and depression; CESC cis rs7089973 0.604 rs11196929 chr10:116582080 G/C cg25233709 chr10:116636983 FAM160B1 0.34 5.31 0.31 2.31e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs3780486 0.505 rs7868663 chr9:33141229 A/G cg20290983 chr6:43655470 MRPS18A 0.76 12.2 0.6 1.82e-27 IgG glycosylation; CESC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg11890956 chr21:40555474 PSMG1 -0.97 -15.94 -0.7 1.46e-40 Cognitive function; CESC cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg06212747 chr3:49208901 KLHDC8B 0.74 9.86 0.52 9.48e-20 Parkinson's disease; CESC cis rs4253772 0.550 rs11703564 chr22:46722194 G/A cg00784671 chr22:46762841 CELSR1 -0.56 -5.69 -0.33 3.35e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4141404 0.640 rs9606854 chr22:31930567 C/T cg02404636 chr22:31891804 SFI1 0.44 5.33 0.31 2.13e-7 Paclitaxel-induced neuropathy; CESC cis rs7267979 0.509 rs6115218 chr20:25566485 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.57 8.11 0.45 1.88e-14 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22762088 chr20:33581493 MYH7B -0.5 -6.06 -0.35 4.55e-9 Gut microbiome composition (summer); CESC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg07870213 chr5:140052090 DND1 0.64 6.75 0.38 9.18e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11031096 0.711 rs10835694 chr11:4178757 G/C cg18678763 chr11:4115507 RRM1 -0.43 -5.95 -0.34 8.38e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs2953174 1.000 rs2953176 chr2:241520754 T/A cg07929629 chr2:241523174 NA 0.62 5.82 0.34 1.73e-8 Bipolar disorder; CESC cis rs1707322 0.613 rs1473840 chr1:46601197 A/G cg03146154 chr1:46216737 IPP -0.61 -7.28 -0.41 3.76e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4466137 0.830 rs6886695 chr5:82994293 T/A cg16102102 chr5:83017553 HAPLN1 -0.42 -6.15 -0.35 2.81e-9 Prostate cancer; CESC cis rs12142240 0.698 rs56344958 chr1:46814518 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg03934478 chr11:495069 RNH1 0.56 5.27 0.31 2.88e-7 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22212156 chr20:32031449 SNTA1 0.59 6.71 0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg03351412 chr1:154909251 PMVK 0.69 9.15 0.49 1.62e-17 Prostate cancer; CESC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.73 0.38 1.05e-10 Prudent dietary pattern; CESC cis rs12497850 0.966 rs6792510 chr3:48723302 G/C cg03060546 chr3:49711283 APEH 0.44 5.39 0.31 1.58e-7 Parkinson's disease; CESC cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.09 0.3 6.96e-7 Colonoscopy-negative controls vs population controls; CESC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg25124228 chr12:125621409 AACS 0.6 8.24 0.45 7.8e-15 Post bronchodilator FEV1/FVC ratio; CESC trans rs4709783 0.738 rs9364708 chr6:164309316 A/G cg26167625 chr4:7770639 AFAP1;LOC84740 0.42 6.0 0.35 6.58e-9 Parental longevity (mother's age at death); CESC trans rs829883 1.000 rs249839 chr12:98872364 T/C cg04550079 chr16:67212681 KIAA0895L -0.38 -6.2 -0.36 2.1e-9 Colorectal adenoma (advanced); CESC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -6.96 -0.39 2.62e-11 Total body bone mineral density; CESC cis rs7819412 0.521 rs11777887 chr8:11036799 C/G cg21775007 chr8:11205619 TDH 0.39 5.07 0.3 7.32e-7 Triglycerides; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24058025 chr1:44412156 IPO13 -0.5 -6.09 -0.35 3.95e-9 Ulcerative colitis; CESC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3820068 0.603 rs56032936 chr1:15970953 T/C cg18133145 chr1:16060689 PLEKHM2 -0.39 -5.04 -0.3 8.81e-7 Systolic blood pressure; CESC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg14196790 chr5:131705035 SLC22A5 0.4 5.68 0.33 3.53e-8 Blood metabolite levels; CESC cis rs11630290 0.592 rs1912049 chr15:64155606 G/T cg12036633 chr15:63758958 NA 0.45 5.45 0.32 1.13e-7 Iris characteristics; CESC cis rs2404602 0.608 rs12911035 chr15:76606591 T/C cg26408565 chr15:76604113 ETFA -0.42 -6.16 -0.35 2.64e-9 Blood metabolite levels; CESC cis rs9858542 1.000 rs9836291 chr3:49697459 G/A cg03060546 chr3:49711283 APEH -0.58 -6.9 -0.39 3.87e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9914544 1.000 rs7223231 chr17:18811846 C/T cg26378065 chr17:18585709 ZNF286B 0.46 6.03 0.35 5.61e-9 Educational attainment (years of education); CESC cis rs3806843 0.657 rs2563283 chr5:140105978 C/A cg26395211 chr5:140044315 WDR55 0.47 6.05 0.35 4.82e-9 Depressive symptoms (multi-trait analysis); CESC cis rs2645694 0.626 rs2703143 chr4:77830441 A/G cg10057126 chr4:77819792 ANKRD56 0.6 8.45 0.46 1.91e-15 Emphysema distribution in smoking; CESC cis rs12765878 1.000 rs35223321 chr10:105646395 C/T cg24587175 chr10:105670608 OBFC1 0.32 5.22 0.31 3.58e-7 Coronary artery disease; CESC cis rs1178968 1.000 rs4717756 chr7:72765458 C/G cg25889504 chr7:72793014 NA -0.47 -5.07 -0.3 7.47e-7 Triglyceride levels; CESC cis rs911555 0.755 rs6575988 chr14:103900827 G/T cg12935359 chr14:103987150 CKB 0.52 7.62 0.42 4.4e-13 Intelligence (multi-trait analysis); CESC cis rs367615 0.704 rs7726991 chr5:108847434 C/T cg17395555 chr5:108820864 NA 0.63 11.15 0.57 6.1e-24 Colorectal cancer (SNP x SNP interaction); CESC cis rs9811920 0.609 rs793463 chr3:99620252 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs2204008 0.713 rs11173567 chr12:38089375 T/C cg26384229 chr12:38710491 ALG10B 0.65 8.86 0.48 1.23e-16 Bladder cancer; CESC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.49 -0.32 9.46e-8 Menopause (age at onset); CESC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg12667521 chr19:29218732 NA 0.48 6.4 0.37 6.97e-10 Methadone dose in opioid dependence; CESC cis rs561341 0.883 rs7406056 chr17:30220224 C/T cg19193384 chr17:30244184 NA -0.55 -5.82 -0.34 1.65e-8 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.59 -7.36 -0.41 2.29e-12 Prudent dietary pattern; CESC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg22920501 chr2:26401640 FAM59B 0.91 10.33 0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs1267820 chr7:66050295 C/G cg12463550 chr7:65579703 CRCP 0.72 5.62 0.33 4.87e-8 Diabetic kidney disease; CESC cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg11645453 chr3:52864694 ITIH4 -0.28 -5.65 -0.33 4.13e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg00166722 chr3:10149974 C3orf24 0.48 5.98 0.34 7.12e-9 Alzheimer's disease; CESC cis rs9911578 1.000 rs4398153 chr17:56968181 T/C cg05425664 chr17:57184151 TRIM37 0.49 6.71 0.38 1.19e-10 Intelligence (multi-trait analysis); CESC cis rs698833 0.710 rs1441048 chr2:44511929 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.43 5.27 0.31 2.8e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs10870270 0.956 rs11146425 chr10:133734261 C/T cg08754478 chr10:133766260 PPP2R2D -0.62 -8.06 -0.44 2.63e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs56235845 0.665 rs4976685 chr5:176766177 C/T cg17509989 chr5:176798049 RGS14 -0.52 -6.89 -0.39 4.16e-11 Hemoglobin concentration;Hematocrit; CESC cis rs113835537 0.597 rs10896129 chr11:66338300 T/C cg22134325 chr11:66188745 NPAS4 0.37 5.56 0.32 6.61e-8 Airway imaging phenotypes; CESC cis rs6484504 0.600 rs12796587 chr11:31266443 T/C cg14844989 chr11:31128820 NA -0.41 -5.82 -0.34 1.73e-8 Red blood cell count; CESC cis rs868036 0.645 rs4776972 chr15:68083436 A/C cg08079166 chr15:68083412 MAP2K5 0.43 5.88 0.34 1.23e-8 Restless legs syndrome; CESC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg23590916 chr17:43697445 MGC57346 -0.61 -6.51 -0.37 3.66e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg02487422 chr3:49467188 NICN1 0.4 5.15 0.3 5.11e-7 Parkinson's disease; CESC cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.77 8.79 0.48 1.96e-16 Alzheimer's disease; CESC cis rs5750830 0.594 rs9611165 chr22:39775250 A/G cg24399712 chr22:39784796 NA -0.77 -11.05 -0.56 1.34e-23 Intelligence (multi-trait analysis); CESC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg24531977 chr5:56204891 C5orf35 0.48 5.78 0.33 2.09e-8 Coronary artery disease; CESC cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg02079420 chr8:82753780 SNX16 0.57 7.64 0.42 3.93e-13 Diastolic blood pressure; CESC cis rs6060717 0.529 rs6060535 chr20:34235522 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -7.54 -0.42 7.43e-13 Hip circumference adjusted for BMI; CESC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg26354017 chr1:205819088 PM20D1 -0.41 -5.42 -0.32 1.31e-7 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs6484504 0.553 rs7113880 chr11:31279557 A/G cg14844989 chr11:31128820 NA -0.37 -5.25 -0.31 3.12e-7 Red blood cell count; CESC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg11890956 chr21:40555474 PSMG1 -0.62 -7.96 -0.44 4.92e-14 Menarche (age at onset); CESC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg17971929 chr21:40555470 PSMG1 -0.6 -8.02 -0.44 3.31e-14 Menarche (age at onset); CESC cis rs4629180 0.544 rs7595274 chr2:102140086 T/C cg04415270 chr2:102091202 RFX8 -0.31 -5.36 -0.31 1.81e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.42 -6.98 -0.39 2.33e-11 Personality dimensions; CESC cis rs3213545 0.700 rs2260399 chr12:121469653 C/T cg15155738 chr12:121454335 C12orf43 0.51 6.23 0.36 1.79e-9 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs4268898 0.529 rs4426488 chr2:24372815 A/G cg06627628 chr2:24431161 ITSN2 0.6 8.23 0.45 8.28e-15 Asthma; CESC cis rs34779708 0.733 rs7087099 chr10:35541982 C/T cg03585969 chr10:35415529 CREM 0.56 6.48 0.37 4.34e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg12516959 chr21:47718080 NA -0.38 -5.32 -0.31 2.22e-7 Testicular germ cell tumor; CESC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg05368731 chr17:41323189 NBR1 0.6 8.36 0.46 3.63e-15 Menopause (age at onset); CESC cis rs72781680 0.566 rs6713979 chr2:23899876 A/G cg08917208 chr2:24149416 ATAD2B 0.7 6.86 0.39 4.99e-11 Lymphocyte counts; CESC cis rs2777491 0.957 rs8026197 chr15:41711447 C/T cg02330683 chr15:41787940 ITPKA 0.48 7.12 0.4 1.01e-11 Ulcerative colitis; CESC cis rs8112211 0.834 rs11881305 chr19:38804218 A/G cg14299480 chr19:38876666 GGN -0.43 -5.85 -0.34 1.46e-8 Blood protein levels; CESC trans rs1973993 0.903 rs2038646 chr1:96940371 C/G cg10631902 chr5:14652156 NA 0.5 6.7 0.38 1.28e-10 Weight; CESC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg18876405 chr7:65276391 NA 0.51 5.91 0.34 1.04e-8 Aortic root size; CESC cis rs9788682 0.624 rs518425 chr15:78883813 A/G cg24631222 chr15:78858424 CHRNA5 0.67 8.24 0.45 7.82e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs12155623 0.619 rs17641604 chr8:49842784 C/T cg22283653 chr8:49824208 NA 0.36 5.44 0.32 1.19e-7 Sudden cardiac arrest; CESC cis rs9811920 0.609 rs6440938 chr3:99652092 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.59 -7.22 -0.41 5.61e-12 Axial length; CESC cis rs6500395 1.000 rs11641458 chr16:48670845 C/T cg04672837 chr16:48644449 N4BP1 0.51 6.43 0.37 6.06e-10 Response to tocilizumab in rheumatoid arthritis; CESC trans rs3008706 0.790 rs2987040 chr9:16002275 G/C cg09705784 chr17:76565232 DNAH17 0.56 6.01 0.35 6.16e-9 Bilirubin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04386144 chr6:43970475 C6orf223 0.74 8.35 0.46 3.8e-15 Gut microbiome composition (summer); CESC cis rs2439831 0.702 rs2467402 chr15:44024490 A/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.58 -6.15 -0.35 2.81e-9 Lung cancer in ever smokers; CESC cis rs2404602 0.647 rs11631959 chr15:77040048 T/C cg23625390 chr15:77176239 SCAPER -0.47 -6.52 -0.37 3.54e-10 Blood metabolite levels; CESC cis rs2625529 0.617 rs2929509 chr15:72239272 T/C cg16672083 chr15:72433130 SENP8 0.4 6.04 0.35 5.3300000000000004e-09 Red blood cell count; CESC cis rs2635047 0.530 rs4986228 chr18:44595259 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 5.81 0.34 1.82e-8 Educational attainment; CESC cis rs9309473 0.500 rs2421664 chr2:73858881 C/T cg20560298 chr2:73613845 ALMS1 0.49 6.88 0.39 4.43e-11 Metabolite levels; CESC cis rs17376456 0.877 rs10050465 chr5:93349963 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.2 0.3 3.97e-7 Diabetic retinopathy; CESC cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg22875332 chr1:76189707 ACADM 0.59 6.78 0.38 7.6e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs763121 0.853 rs5750627 chr22:38982321 A/G cg06544989 chr22:39130855 UNC84B 0.5 9.13 0.49 1.8e-17 Menopause (age at onset); CESC trans rs35110281 0.782 rs1584917 chr21:45042365 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 6.87 0.39 4.49e-11 Mean corpuscular volume; CESC cis rs698813 0.604 rs10865200 chr2:44482884 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.59 0.32 5.78e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg04315214 chr1:2043799 PRKCZ 0.64 11.39 0.57 9.85e-25 Height; CESC cis rs3026101 0.671 rs3944127 chr17:5297766 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs12973672 1.000 rs2280747 chr19:35770064 C/T cg12095397 chr19:35769544 USF2 0.54 7.35 0.41 2.49e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs916888 0.610 rs199452 chr17:44801340 C/T cg17911788 chr17:44343683 NA -0.44 -7.03 -0.4 1.77e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1580019 0.568 rs2122633 chr7:32523870 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.41 0.37 6.82e-10 Cognitive ability; CESC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs6500602 0.673 rs4786513 chr16:4576423 T/C cg08645402 chr16:4508243 NA 0.39 6.03 0.35 5.36e-9 Schizophrenia; CESC cis rs12530845 0.673 rs4073627 chr7:135312572 A/G cg23117316 chr7:135346802 PL-5283 0.52 6.16 0.35 2.68e-9 Red blood cell traits; CESC cis rs2832077 0.527 rs2738953 chr21:30238363 G/C cg08807101 chr21:30365312 RNF160 0.53 6.54 0.37 3.13e-10 Cognitive test performance; CESC cis rs2243480 1.000 rs58669269 chr7:65951953 T/C cg13147721 chr7:65941812 NA -0.94 -8.74 -0.47 2.71e-16 Diabetic kidney disease; CESC cis rs6570726 0.935 rs12663204 chr6:145818373 G/A cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg17911788 chr17:44343683 NA 0.43 6.87 0.39 4.55e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07113549 chr3:98312651 CPOX -0.42 -6.05 -0.35 4.93e-9 Gambling; CESC cis rs2228479 0.717 rs1800358 chr16:89809319 T/C cg27121462 chr16:89883253 FANCA 0.63 5.51 0.32 8.36e-8 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21300382 chr19:13248092 NACC1 -0.55 -6.29 -0.36 1.29e-9 Gut microbiome composition (summer); CESC cis rs2439831 0.571 rs689883 chr15:43812596 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.8 8.57 0.47 8.59e-16 Lung cancer in ever smokers; CESC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg22535103 chr8:58192502 C8orf71 -0.76 -8.74 -0.47 2.65e-16 Developmental language disorder (linguistic errors); CESC cis rs12425451 0.552 rs10848765 chr12:3141495 C/T cg05389053 chr12:3131226 TEAD4 0.52 6.17 0.35 2.48e-9 Narcolepsy with cataplexy; CESC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg05754148 chr16:3507555 NAT15 -0.63 -6.18 -0.35 2.46e-9 Tuberculosis; CESC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.71 0.33 2.98e-8 Bipolar disorder; CESC cis rs7474896 0.515 rs624359 chr10:38299132 T/C cg00409905 chr10:38381863 ZNF37A 0.46 5.15 0.3 5.06e-7 Obesity (extreme); CESC cis rs761746 0.960 rs5753734 chr22:32028721 A/C cg25791279 chr22:32026902 PISD 0.55 6.66 0.38 1.55e-10 Intelligence; CESC cis rs60154123 0.730 rs689248 chr1:210463122 A/G cg25204440 chr1:209979598 IRF6 -0.47 -5.27 -0.31 2.87e-7 Coronary artery disease; CESC cis rs11122272 0.735 rs2486737 chr1:231520523 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs7605827 0.930 rs11903302 chr2:15706286 C/T cg19274914 chr2:15703543 NA 0.34 5.96 0.34 8.13e-9 Educational attainment (years of education); CESC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg08470875 chr2:26401718 FAM59B 0.47 5.1 0.3 6.57e-7 Gut microbiome composition (summer); CESC cis rs7662987 0.517 rs1377689 chr4:100021787 A/G cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.21e-14 Smoking initiation; CESC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg24101359 chr6:42928495 GNMT 0.56 7.93 0.44 6.17e-14 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2635047 0.625 rs1836259 chr18:44732389 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 5.42 0.32 1.31e-7 Educational attainment; CESC cis rs34734847 0.766 rs3794214 chr12:121168245 C/T cg26008908 chr12:120799332 MSI1 -0.33 -5.19 -0.3 4.21e-7 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25428156 chr4:119556601 NA -0.58 -8.42 -0.46 2.42e-15 Gut microbiome composition (summer); CESC cis rs8170 0.603 rs11086068 chr19:17420165 T/C cg04749549 chr19:17459798 NA -0.34 -5.56 -0.32 6.61e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CESC cis rs9543976 0.623 rs7139740 chr13:76166942 C/T cg01531495 chr13:76123901 UCHL3 0.5 5.03 0.3 9.04e-7 Diabetic retinopathy; CESC cis rs67311347 0.955 rs6782746 chr3:40510592 A/G cg01475735 chr3:40494733 NA 0.41 5.17 0.3 4.71e-7 Renal cell carcinoma; CESC cis rs1153858 1.000 rs8032904 chr15:45651309 C/T cg21132104 chr15:45694354 SPATA5L1 0.85 11.57 0.58 2.4e-25 Homoarginine levels; CESC trans rs1814175 0.533 rs4528310 chr11:49983106 C/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.24 -0.36 1.75e-9 Height; CESC cis rs2066819 1.000 rs744051 chr12:56667298 C/T cg26734620 chr12:56694298 CS -1.0 -6.49 -0.37 4.12e-10 Psoriasis vulgaris; CESC cis rs7044106 1.000 rs7044106 chr9:123494062 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.72 8.55 0.46 1.02e-15 Hip circumference adjusted for BMI; CESC cis rs9612 0.718 rs346532 chr19:44248878 A/G cg08581076 chr19:44259116 C19orf61 0.46 5.56 0.32 6.54e-8 Exhaled nitric oxide output; CESC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg23758822 chr17:41437982 NA 0.97 17.29 0.73 2.39e-45 Menopause (age at onset); CESC cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg24531977 chr5:56204891 C5orf35 0.57 6.87 0.39 4.44e-11 Coronary artery disease; CESC cis rs1267303 0.642 rs1267301 chr1:46992853 C/G cg25110126 chr1:46999211 NA -1.04 -10.98 -0.56 2.23e-23 Monobrow; CESC cis rs72781680 0.756 rs2712059 chr2:24020539 T/C cg08917208 chr2:24149416 ATAD2B 0.61 5.99 0.35 6.76e-9 Lymphocyte counts; CESC cis rs3096299 0.702 rs2086825 chr16:89471542 C/T cg00750074 chr16:89608354 SPG7 -0.39 -5.36 -0.31 1.81e-7 Multiple myeloma (IgH translocation); CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg18876405 chr7:65276391 NA 0.48 6.48 0.37 4.51e-10 Calcium levels; CESC trans rs11039798 1.000 rs11039904 chr11:48682597 T/A cg15704280 chr7:45808275 SEPT13 0.7 6.38 0.36 7.68e-10 Axial length; CESC cis rs3749237 0.555 rs7637665 chr3:49552295 T/C cg03060546 chr3:49711283 APEH 0.76 11.62 0.58 1.73e-25 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17709466 chr12:56618184 OBFC2B 0.61 6.31 0.36 1.16e-9 Gut microbiome composition (summer); CESC cis rs7918232 1.000 rs6482595 chr10:27380261 A/G cg14442939 chr10:27389572 ANKRD26 -0.57 -6.03 -0.35 5.51e-9 Breast cancer; CESC cis rs9403521 1.000 rs116980222 chr6:143998987 C/T cg18240653 chr6:144019428 PHACTR2 -0.48 -5.36 -0.31 1.81e-7 Obesity-related traits; CESC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg27121462 chr16:89883253 FANCA -0.44 -5.31 -0.31 2.37e-7 Vitiligo; CESC cis rs250677 1.000 rs36080 chr5:148430451 A/G cg18129178 chr5:148520854 ABLIM3 -0.48 -5.56 -0.32 6.72e-8 Breast cancer; CESC cis rs561341 1.000 rs550264 chr17:30317540 G/T cg12193833 chr17:30244370 NA -0.72 -6.64 -0.38 1.78e-10 Hip circumference adjusted for BMI; CESC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg17372223 chr3:52568218 NT5DC2 0.43 6.51 0.37 3.76e-10 Bipolar disorder; CESC cis rs17854409 0.764 rs8116995 chr20:61475824 A/G cg07645718 chr20:61493192 TCFL5 0.79 5.68 0.33 3.48e-8 Obesity-related traits; CESC cis rs34779708 0.766 rs7897088 chr10:35551567 G/T cg03585969 chr10:35415529 CREM 0.54 6.14 0.35 2.99e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs17401966 0.964 rs34215045 chr1:10361679 G/A cg15208524 chr1:10270712 KIF1B 0.51 6.55 0.37 2.91e-10 Hepatocellular carcinoma; CESC cis rs926938 0.841 rs11588144 chr1:115239355 G/A cg12756093 chr1:115239321 AMPD1 -0.72 -11.49 -0.58 4.71e-25 Autism; CESC cis rs34779708 0.733 rs4444023 chr10:35548354 G/A cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg12288994 chr5:1860383 NA 0.43 7.13 0.4 9.62e-12 Cardiovascular disease risk factors; CESC cis rs6831352 0.819 rs2851274 chr4:100025866 G/C cg12011299 chr4:100065546 ADH4 0.65 8.28 0.45 6.2e-15 Alcohol dependence; CESC cis rs9322193 0.962 rs4870048 chr6:150155460 A/G cg07701084 chr6:150067640 NUP43 0.4 5.26 0.31 2.97e-7 Lung cancer; CESC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg01741372 chr11:783889 NA -0.55 -8.24 -0.45 8.17e-15 Breast cancer; CESC cis rs7927771 1.000 rs12787330 chr11:47812311 C/T cg18512352 chr11:47633146 NA -0.6 -9.57 -0.51 8.16e-19 Subjective well-being; CESC trans rs9467711 0.606 rs9379900 chr6:26603811 A/C cg01620082 chr3:125678407 NA -0.64 -6.33 -0.36 1.03e-9 Autism spectrum disorder or schizophrenia; CESC cis rs4704187 0.663 rs56012051 chr5:74551828 A/G cg03227963 chr5:74354835 NA 0.29 5.43 0.32 1.27e-7 Response to amphetamines; CESC cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.32 0.31 2.18e-7 Colonoscopy-negative controls vs population controls; CESC trans rs1814175 0.619 rs10769623 chr11:49865926 C/T cg03929089 chr4:120376271 NA -0.88 -14.39 -0.66 4.31e-35 Height; CESC cis rs17253792 0.822 rs12100753 chr14:56042870 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.93 0.34 9.48e-9 Putamen volume; CESC cis rs250677 1.000 rs36082 chr5:148428844 C/G cg18129178 chr5:148520854 ABLIM3 -0.5 -5.43 -0.32 1.3e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18568647 chr15:90174826 KIF7 -0.66 -8.05 -0.44 2.76e-14 Gut microbiome composition (summer); CESC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg03452623 chr4:187889614 NA -0.89 -14.8 -0.67 1.53e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs7727544 0.684 rs2516788 chr5:131715565 G/C cg07395648 chr5:131743802 NA 0.45 5.93 0.34 9.66e-9 Blood metabolite levels; CESC cis rs2191566 0.691 rs56182773 chr19:44588325 G/T cg20607764 chr19:44506953 ZNF230 -0.4 -5.31 -0.31 2.28e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.606 rs10006454 chr4:99080361 G/A cg05340658 chr4:99064831 C4orf37 0.65 8.94 0.48 6.63e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2239547 0.657 rs4687672 chr3:52880543 G/A cg11645453 chr3:52864694 ITIH4 0.33 6.12 0.35 3.3e-9 Schizophrenia; CESC cis rs763014 0.931 rs10903017 chr16:627920 T/C cg00802000 chr16:706648 WDR90 -0.42 -6.36 -0.36 8.74e-10 Height; CESC cis rs8060686 0.516 rs7187202 chr16:68273895 T/C cg26727032 chr16:67993705 SLC12A4 -0.53 -7.01 -0.4 2.01e-11 HDL cholesterol;Metabolic syndrome; CESC cis rs12681288 0.676 rs2701913 chr8:999982 A/T cg04851639 chr8:1020857 NA -0.32 -6.79 -0.38 7.37e-11 Schizophrenia; CESC cis rs4268898 0.552 rs35331966 chr2:24367828 C/T cg06627628 chr2:24431161 ITSN2 0.59 8.19 0.45 1.15e-14 Asthma; CESC cis rs8111998 0.826 rs4932777 chr19:22766764 C/T cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg25987502 chr17:6899865 ALOX12 -0.41 -6.66 -0.38 1.55e-10 Tonsillectomy; CESC cis rs858239 0.669 rs1990365 chr7:23115966 T/C cg27449745 chr7:23145252 KLHL7 -0.49 -6.39 -0.37 7.54e-10 Cerebrospinal fluid biomarker levels; CESC cis rs2274273 0.686 rs11624679 chr14:55624244 G/A cg04306507 chr14:55594613 LGALS3 0.31 5.26 0.31 2.99e-7 Protein biomarker; CESC cis rs854765 1.000 rs854765 chr17:18012730 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.46 -5.6 -0.33 5.44e-8 Total body bone mineral density; CESC cis rs10927875 0.722 rs945425 chr1:16348412 T/C cg21385522 chr1:16154831 NA 0.59 6.95 0.39 2.89e-11 Dilated cardiomyopathy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26947572 chr2:10442852 HPCAL1 -0.45 -6.11 -0.35 3.48e-9 Fibrinogen levels; CESC cis rs1799949 0.965 rs7223952 chr17:41194885 T/C cg25072359 chr17:41440525 NA 0.51 7.39 0.41 1.91e-12 Menopause (age at onset); CESC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg00166722 chr3:10149974 C3orf24 0.47 6.05 0.35 4.96e-9 Alzheimer's disease; CESC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg01017244 chr2:74357527 NA 0.71 10.57 0.54 4.91e-22 Gestational age at birth (maternal effect); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10717766 chr19:5134118 KDM4B 0.45 6.23 0.36 1.78e-9 Fibrinogen levels; CESC cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC trans rs8073060 0.586 rs6505485 chr17:33996102 C/T cg19694781 chr19:47549865 TMEM160 -0.74 -6.49 -0.37 4.23e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs10791097 0.694 rs10791103 chr11:130757161 G/A cg09137382 chr11:130731461 NA 0.37 5.58 0.32 6.01e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs8141529 0.636 rs5762799 chr22:29187380 G/T cg15103426 chr22:29168792 CCDC117 0.48 5.11 0.3 6.09e-7 Lymphocyte counts; CESC cis rs9916302 0.904 rs1966916 chr17:37425238 T/G cg15445000 chr17:37608096 MED1 0.4 6.45 0.37 5.35e-10 Glomerular filtration rate (creatinine); CESC trans rs453301 0.624 rs330056 chr8:9089695 A/T cg15556689 chr8:8085844 FLJ10661 -0.53 -6.6 -0.38 2.25e-10 Joint mobility (Beighton score); CESC trans rs10242455 0.571 rs45527841 chr7:99310965 C/T cg09045935 chr12:6379348 NA 0.76 6.38 0.36 7.87e-10 Blood metabolite levels; CESC cis rs763121 0.853 rs10135 chr22:39082174 C/T cg21395723 chr22:39101663 GTPBP1 -0.48 -6.44 -0.37 5.45e-10 Menopause (age at onset); CESC cis rs1538970 0.781 rs12049503 chr1:46021556 G/T cg06784218 chr1:46089804 CCDC17 0.37 5.83 0.34 1.61e-8 Platelet count; CESC cis rs2070677 0.597 rs1410898 chr10:135295455 G/T cg20169779 chr10:135381914 SYCE1 0.42 5.4 0.32 1.46e-7 Gout; CESC cis rs2204008 0.683 rs7305703 chr12:38138381 T/C cg13010199 chr12:38710504 ALG10B 0.49 5.99 0.35 6.72e-9 Bladder cancer; CESC cis rs4919694 1.000 rs77969925 chr10:104649357 C/T cg04362960 chr10:104952993 NT5C2 0.74 6.45 0.37 5.32e-10 Arsenic metabolism; CESC cis rs1062177 1.000 rs2964571 chr5:151171256 C/T cg00977110 chr5:151150581 G3BP1 0.66 7.11 0.4 1.06e-11 Preschool internalizing problems; CESC cis rs2228479 0.681 rs10153055 chr16:89965842 C/T cg04013166 chr16:89971882 TCF25 0.71 8.56 0.47 9.33e-16 Skin colour saturation; CESC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg03806693 chr22:41940476 POLR3H -0.99 -11.88 -0.59 2.25e-26 Vitiligo; CESC cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg04398451 chr17:18023971 MYO15A -0.67 -9.46 -0.5 1.75e-18 Total body bone mineral density; CESC cis rs12618769 0.597 rs1587835 chr2:99041269 A/C cg10123293 chr2:99228465 UNC50 0.39 5.1 0.3 6.52e-7 Bipolar disorder; CESC cis rs4523957 0.855 rs9896535 chr17:2133205 C/T cg16513277 chr17:2031491 SMG6 -0.63 -8.99 -0.48 4.73e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1451375 0.572 rs896309 chr7:50545022 A/G cg14593290 chr7:50529359 DDC -0.54 -6.6 -0.38 2.25e-10 Malaria; CESC cis rs1707322 0.686 rs2050376 chr1:46078630 C/T cg05343316 chr1:45956843 TESK2 0.5 6.13 0.35 3.17e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1008375 0.900 rs12650220 chr4:17595365 A/T cg02297831 chr4:17616191 MED28 0.46 5.72 0.33 2.82e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg07157834 chr1:205819609 PM20D1 -0.41 -5.51 -0.32 8.62e-8 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.52 -5.85 -0.34 1.41e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg15369054 chr17:80825471 TBCD -0.37 -5.42 -0.32 1.34e-7 Breast cancer; CESC cis rs853679 0.546 rs17695758 chr6:27837183 T/C cg18032046 chr6:28092343 ZSCAN16 -0.75 -5.22 -0.31 3.68e-7 Depression; CESC cis rs1448094 0.511 rs2405623 chr12:86153466 G/A cg02569458 chr12:86230093 RASSF9 -0.42 -6.46 -0.37 4.89e-10 Major depressive disorder; CESC cis rs4523957 0.614 rs1563966 chr17:2095954 A/G cg16513277 chr17:2031491 SMG6 0.56 7.34 0.41 2.68e-12 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7246657 0.943 rs7253091 chr19:37967214 C/T cg23950597 chr19:37808831 NA -0.57 -6.22 -0.36 1.96e-9 Coronary artery calcification; CESC cis rs11958404 0.932 rs72816550 chr5:157418457 A/T cg05962755 chr5:157440814 NA 0.58 6.53 0.37 3.31e-10 IgG glycosylation; CESC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg19592336 chr6:28129416 ZNF389 -0.63 -8.8 -0.48 1.82e-16 Depression; CESC cis rs7914558 0.869 rs10883842 chr10:104941589 C/T cg15744005 chr10:104629667 AS3MT -0.31 -5.04 -0.3 8.72e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs737337 0.623 rs4804154 chr19:11334179 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.54 5.66 0.33 4.02e-8 HDL cholesterol;HDL cholesterol levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11891431 chr5:178209272 NA -0.38 -6.0 -0.35 6.55e-9 Systemic lupus erythematosus; CESC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg12648201 chr2:27665141 KRTCAP3 0.3 5.32 0.31 2.19e-7 Total body bone mineral density; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg14172412 chr1:87797008 LMO4 -0.44 -6.58 -0.37 2.54e-10 Vertical cup-disc ratio; CESC cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg24531977 chr5:56204891 C5orf35 0.69 9.25 0.49 8.04e-18 Initial pursuit acceleration; CESC cis rs941408 0.515 rs1005556 chr19:2778543 G/T cg00079169 chr19:2811669 THOP1 0.39 5.44 0.32 1.19e-7 Total cholesterol levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26583560 chr16:896768 NA 0.37 6.04 0.35 5.1e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22233523 chr18:44497604 PIAS2 0.66 7.78 0.43 1.59e-13 Gut microbiome composition (summer); CESC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg02564969 chr6:151773285 C6orf211;RMND1 -0.61 -8.46 -0.46 1.83e-15 Menarche (age at onset); CESC cis rs10752881 1.000 rs12133714 chr1:182988252 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.79e-31 Colorectal cancer; CESC cis rs751837 0.518 rs17101146 chr14:103463599 A/G cg10087771 chr14:103399429 CDC42BPB -0.59 -5.42 -0.32 1.35e-7 Large B-cell lymphoma; CESC cis rs2228479 0.850 rs12596934 chr16:89841605 T/G cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14477673 chr9:6835001 KDM4C -0.59 -6.75 -0.38 9.23e-11 Gut microbiome composition (summer); CESC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg24060327 chr5:131705240 SLC22A5 -0.73 -10.13 -0.53 1.36e-20 Breast cancer; CESC cis rs6088590 0.901 rs6087631 chr20:33403509 T/C cg24642439 chr20:33292090 TP53INP2 0.84 11.74 0.58 6.85e-26 Coronary artery disease; CESC cis rs826838 1.000 rs10875717 chr12:38911174 T/C cg26384229 chr12:38710491 ALG10B 0.82 14.52 0.67 1.49e-35 Heart rate; CESC trans rs877282 0.682 rs2265092 chr10:780293 C/T cg22713356 chr15:30763199 NA -0.55 -6.02 -0.35 5.89e-9 Uric acid levels; CESC cis rs2637266 0.967 rs12246605 chr10:78352994 G/A cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC trans rs35110281 0.774 rs141521 chr21:44963686 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 6.37 0.36 8.35e-10 Mean corpuscular volume; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg10150615 chr22:24372951 LOC391322 -0.49 -6.29 -0.36 1.32e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9399135 0.967 rs7750300 chr6:135350950 C/G cg22676075 chr6:135203613 NA 0.5 7.12 0.4 1.04e-11 Red blood cell count; CESC cis rs6546537 0.550 rs4241252 chr2:69777065 C/A cg10773587 chr2:69614142 GFPT1 -0.44 -5.73 -0.33 2.74e-8 Serum thyroid-stimulating hormone levels; CESC cis rs2276314 0.947 rs3898595 chr18:33565885 T/A cg19628046 chr18:33552617 C18orf21 0.55 6.03 0.35 5.49e-9 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7772486 0.686 rs9497395 chr6:146013592 A/G cg23711669 chr6:146136114 FBXO30 -0.89 -12.51 -0.61 1.62e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs80130819 0.688 rs10783233 chr12:48590899 C/G cg07561017 chr12:48398056 COL2A1 0.39 5.29 0.31 2.62e-7 Prostate cancer; CESC cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg04025307 chr7:1156635 C7orf50 0.37 5.57 0.32 6.18e-8 Bronchopulmonary dysplasia; CESC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs6500602 0.893 rs6500598 chr16:4470964 G/T cg08645402 chr16:4508243 NA 0.37 5.25 0.31 3.17e-7 Schizophrenia; CESC cis rs10883723 0.810 rs10883728 chr10:104269301 A/G cg22532475 chr10:104410764 TRIM8 0.34 5.74 0.33 2.62e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs4268898 0.662 rs9784114 chr2:24437517 C/T cg20701182 chr2:24300061 SF3B14 0.68 7.16 0.4 7.75e-12 Asthma; CESC cis rs116095464 0.558 rs10036253 chr5:238519 A/C cg22857025 chr5:266934 NA -1.29 -18.85 -0.76 7.29e-51 Breast cancer; CESC cis rs796364 0.951 rs7565005 chr2:201013277 A/G cg23649088 chr2:200775458 C2orf69 -0.58 -5.92 -0.34 9.75e-9 Schizophrenia; CESC cis rs7212590 0.618 rs56142307 chr17:57878149 A/G cg20303301 chr17:57937339 TUBD1 -0.54 -5.22 -0.31 3.66e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14183313 chr9:130007677 NA -0.46 -6.12 -0.35 3.28e-9 Fibrinogen levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02904235 chr14:91527369 RPS6KA5 -0.55 -6.88 -0.39 4.43e-11 Asthma; CESC cis rs5753618 0.555 rs5749291 chr22:31907523 C/G cg13145458 chr22:31556086 RNF185 -0.48 -5.68 -0.33 3.51e-8 Colorectal cancer; CESC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg22029157 chr1:209979665 IRF6 0.77 8.52 0.46 1.23e-15 Cleft lip with or without cleft palate; CESC cis rs2730245 0.510 rs2788471 chr7:158649786 G/T cg24397884 chr7:158709396 WDR60 0.68 9.86 0.52 1e-19 Height; CESC cis rs780096 1.000 rs780096 chr2:27741072 C/G cg21248554 chr2:27665150 KRTCAP3 -0.26 -5.1 -0.3 6.52e-7 Total body bone mineral density; CESC cis rs9488822 0.676 rs873879 chr6:116391259 A/G cg26893134 chr6:116381904 FRK 0.25 6.24 0.36 1.71e-9 Cholesterol, total;LDL cholesterol; CESC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.4 0.54 1.84e-21 Prudent dietary pattern; CESC cis rs4253772 0.637 rs8135997 chr22:46651366 G/A cg09491104 chr22:46646882 C22orf40 -0.59 -9.15 -0.49 1.58e-17 LDL cholesterol;Cholesterol, total; CESC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.53 -0.42 7.92e-13 Gut microbiome composition (summer); CESC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg25566285 chr7:158114605 PTPRN2 0.5 8.19 0.45 1.11e-14 Calcium levels; CESC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg17949981 chr6:28129498 ZNF389 0.44 5.58 0.32 5.97e-8 Depression; CESC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg09359103 chr1:154839909 KCNN3 -0.56 -9.62 -0.51 5.59e-19 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14093526 chr11:134094620 VPS26B;NCAPD3 0.53 6.52 0.37 3.6e-10 Gut microbiome composition (summer); CESC cis rs56046484 0.956 rs35045545 chr15:85664951 A/G cg08123816 chr15:85640762 PDE8A -0.5 -6.19 -0.36 2.23e-9 Testicular germ cell tumor; CESC cis rs3733585 0.673 rs9993410 chr4:9951264 C/T cg11266682 chr4:10021025 SLC2A9 -0.59 -11.11 -0.56 8.58e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg23982607 chr1:1823379 GNB1 -0.76 -12.19 -0.6 2.02e-27 Body mass index; CESC cis rs9486715 1.000 rs9486715 chr6:97059769 A/C cg18709589 chr6:96969512 KIAA0776 -0.46 -6.4 -0.37 6.94e-10 Headache; CESC cis rs12497850 0.864 rs4521268 chr3:49137904 G/T cg07636037 chr3:49044803 WDR6 1.05 18.71 0.75 2.36e-50 Parkinson's disease; CESC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 10.97 0.56 2.56e-23 Platelet count; CESC cis rs4566357 0.595 rs6707286 chr2:227911400 A/G cg11843606 chr2:227700838 RHBDD1 -0.47 -6.49 -0.37 4.32e-10 Coronary artery disease; CESC cis rs6732160 0.624 rs10865397 chr2:73358292 C/T cg01422370 chr2:73384389 NA 0.33 5.45 0.32 1.16e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03632145 chr6:24403130 MRS2 0.57 6.38 0.36 7.78e-10 Gut microbiome composition (summer); CESC cis rs9309473 0.519 rs1815027 chr2:73831840 T/C cg20560298 chr2:73613845 ALMS1 0.49 7.07 0.4 1.39e-11 Metabolite levels; CESC cis rs6456156 0.792 rs2039321 chr6:167516299 C/T cg07741184 chr6:167504864 NA 0.36 6.39 0.37 7.38e-10 Primary biliary cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09284707 chr11:107799080 RAB39 0.46 6.59 0.38 2.41e-10 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.5 0.37 3.95e-10 Bipolar disorder; CESC cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg17366294 chr4:99064904 C4orf37 0.62 8.54 0.46 1.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7560272 0.723 rs6744697 chr2:73765438 T/C cg20560298 chr2:73613845 ALMS1 -0.49 -6.92 -0.39 3.47e-11 Schizophrenia; CESC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Depression; CESC cis rs6545883 1.000 rs778763 chr2:61785639 C/G cg15711740 chr2:61764176 XPO1 -0.43 -5.2 -0.3 3.98e-7 Tuberculosis; CESC cis rs9916302 0.784 rs4795382 chr17:37700860 A/G cg07936489 chr17:37558343 FBXL20 -0.8 -11.62 -0.58 1.73e-25 Glomerular filtration rate (creatinine); CESC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg19046167 chr17:80928561 B3GNTL1 0.39 5.26 0.31 2.93e-7 Breast cancer; CESC cis rs56399783 0.614 rs55776032 chr7:2762255 T/C cg19731401 chr7:2775893 GNA12 0.63 5.33 0.31 2.11e-7 Childhood ear infection; CESC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg08968635 chr6:28129556 ZNF389 0.41 5.28 0.31 2.68e-7 Depression; CESC cis rs12476592 0.543 rs12105140 chr2:63797218 A/G cg17519650 chr2:63277830 OTX1 -0.49 -5.45 -0.32 1.16e-7 Childhood ear infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07494914 chr16:46461571 NA -0.52 -6.03 -0.35 5.4e-9 Gut microbiome composition (summer); CESC cis rs9840812 0.610 rs34967300 chr3:136268818 A/G cg15507776 chr3:136538369 TMEM22 -0.5 -5.33 -0.31 2.08e-7 Fibrinogen levels; CESC cis rs7914558 0.901 rs1926034 chr10:104829102 G/A cg04362960 chr10:104952993 NT5C2 0.46 6.18 0.35 2.39e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs916888 0.773 rs199447 chr17:44812188 C/T cg01570182 chr17:44337453 NA 0.88 9.87 0.52 8.81e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs524023 0.914 rs526338 chr11:64418900 G/A cg07220939 chr11:64358617 SLC22A12 -0.36 -5.45 -0.32 1.17e-7 Urate levels in obese individuals; CESC cis rs9303401 0.614 rs12950028 chr17:56510140 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.96 11.77 0.59 5.09e-26 Cognitive test performance; CESC cis rs2742234 0.590 rs1254965 chr10:43689853 C/T cg07801480 chr10:43725741 RASGEF1A -0.41 -5.29 -0.31 2.56e-7 Hirschsprung disease; CESC cis rs6582630 0.502 rs11182760 chr12:38606273 A/T cg26384229 chr12:38710491 ALG10B 0.74 11.15 0.57 6.39e-24 Drug-induced liver injury (flucloxacillin); CESC cis rs17376456 0.825 rs34967135 chr5:93221785 G/A cg21475434 chr5:93447410 FAM172A 0.79 7.07 0.4 1.38e-11 Diabetic retinopathy; CESC cis rs7635838 0.859 rs6768611 chr3:11434465 G/A cg00170343 chr3:11313890 ATG7 0.44 5.6 0.33 5.34e-8 HDL cholesterol; CESC cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg12386194 chr3:101231763 SENP7 0.41 5.16 0.3 4.92e-7 Colorectal cancer; CESC cis rs2603127 0.768 rs6769587 chr3:108502836 A/C cg03329597 chr3:108125523 MYH15 0.58 5.15 0.3 5.2e-7 Hemostatic factors and hematological phenotypes; CESC cis rs9911578 0.967 rs1588322 chr17:56990099 T/C cg12560992 chr17:57184187 TRIM37 0.93 15.26 0.68 3.55e-38 Intelligence (multi-trait analysis); CESC cis rs7116495 0.881 rs1892921 chr11:71702138 G/A cg26138937 chr11:71823887 C11orf51 -0.81 -6.87 -0.39 4.57e-11 Severe influenza A (H1N1) infection; CESC cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg21518248 chr2:162101506 NA -0.47 -6.39 -0.37 7.63e-10 Intelligence (multi-trait analysis); CESC cis rs10754283 0.967 rs2390763 chr1:90105688 A/G cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs35079454 1 rs35079454 chr1:85780863 AG/A cg16011679 chr1:85725395 C1orf52 0.52 6.16 0.35 2.67e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg12365402 chr11:9010492 NRIP3 -0.47 -7.97 -0.44 4.86e-14 Hemoglobin concentration; CESC cis rs561341 1.000 rs510264 chr17:30323414 A/G cg23018236 chr17:30244563 NA -0.55 -5.3 -0.31 2.42e-7 Hip circumference adjusted for BMI; CESC cis rs13191362 0.507 rs2846519 chr6:163045463 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.52 -6.53 -0.37 3.33e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg21433313 chr16:3507492 NAT15 0.5 7.85 0.43 1.02e-13 Tuberculosis; CESC cis rs2797160 0.547 rs9388442 chr6:125972608 G/C cg05901451 chr6:126070800 HEY2 -0.38 -5.27 -0.31 2.83e-7 Endometrial cancer; CESC cis rs5769765 0.954 rs910799 chr22:50278568 A/G cg02269571 chr22:50332266 NA 0.45 6.14 0.35 2.97e-9 Schizophrenia; CESC cis rs2637266 0.739 rs2579736 chr10:78427688 G/A cg18941641 chr10:78392320 NA 0.41 7.51 0.42 9.03e-13 Pulmonary function; CESC cis rs9549367 0.789 rs12584008 chr13:113881228 C/T cg18105134 chr13:113819100 PROZ -0.66 -8.19 -0.45 1.12e-14 Platelet distribution width; CESC cis rs6691722 0.506 rs11587667 chr1:24715435 C/G cg02336364 chr1:24764700 NIPAL3 0.32 6.4 0.37 7.05e-10 Response to interferon beta in multiple sclerosis; CESC cis rs9457247 1.000 rs430293 chr6:167404958 A/G cg25258033 chr6:167368657 RNASET2 0.39 5.88 0.34 1.26e-8 Crohn's disease; CESC cis rs4835473 0.932 rs34525847 chr4:144656123 T/C cg25736465 chr4:144833511 NA -0.34 -5.45 -0.32 1.15e-7 Immature fraction of reticulocytes; CESC cis rs778371 0.748 rs2675953 chr2:233749565 G/C cg08000102 chr2:233561755 GIGYF2 -0.82 -13.22 -0.63 5.6e-31 Schizophrenia; CESC cis rs77216612 0.840 rs11055030 chr12:12878349 G/C cg09462578 chr12:12878428 APOLD1 -1.01 -15.36 -0.69 1.66e-38 Lymphocyte counts; CESC trans rs11971186 0.793 rs1361987 chr7:126489310 T/A cg10894441 chr11:111169905 C11orf92;C11orf93 -0.48 -6.3 -0.36 1.22e-9 Chemerin levels; CESC cis rs7542091 0.635 rs985431 chr1:210043948 A/T cg21951975 chr1:209979733 IRF6 0.47 8.25 0.45 7.51e-15 Monobrow; CESC cis rs13108904 0.870 rs4974577 chr4:1266046 G/A cg00684032 chr4:1343700 KIAA1530 0.42 5.89 0.34 1.16e-8 Obesity-related traits; CESC cis rs6459804 1.000 rs6459806 chr7:157510483 C/G cg05731713 chr7:157510257 PTPRN2 0.41 6.98 0.39 2.3e-11 Bipolar disorder and schizophrenia; CESC cis rs17021463 0.902 rs2016483 chr4:95229039 A/T cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.66 -0.51 4.01e-19 Testicular germ cell tumor; CESC cis rs7267979 0.934 rs2257464 chr20:25265872 C/T cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs6752107 1.000 rs12994971 chr2:234178453 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.39 5.81 0.34 1.76e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs6701037 0.681 rs6664840 chr1:175128726 A/G cg00321850 chr1:175162397 KIAA0040 -0.42 -6.14 -0.35 3.03e-9 Alcohol dependence; CESC trans rs17536732 0.685 rs41461449 chr4:162858888 A/C cg12177677 chr2:158300475 CYTIP 0.62 6.19 0.36 2.3e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs2228479 0.850 rs62054601 chr16:89811751 C/G cg14709524 chr16:89940631 TCF25 0.89 6.6 0.38 2.22e-10 Skin colour saturation; CESC cis rs13095912 0.962 rs1568664 chr3:185312231 T/C cg11274856 chr3:185301563 NA 0.36 5.78 0.33 2.11e-8 Systolic blood pressure; CESC cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.78 11.18 0.57 4.88e-24 Monocyte percentage of white cells; CESC cis rs11098499 0.954 rs1480931 chr4:120395809 G/T cg24375607 chr4:120327624 NA 0.43 5.34 0.31 2e-7 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07997682 chr22:41418886 NA -0.72 -9.27 -0.49 6.8e-18 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs5750621 chr22:38956166 C/T cg14440974 chr22:39074834 NA -0.4 -5.27 -0.31 2.82e-7 Menopause (age at onset); CESC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg26441486 chr22:50317300 CRELD2 0.42 5.24 0.31 3.33e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08517072 chr5:141258709 PCDH1 -0.55 -6.73 -0.38 1.05e-10 Gut microbiome composition (summer); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg12857786 chr4:83934023 LIN54 -0.53 -7.05 -0.4 1.53e-11 Height; CESC cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg05283184 chr6:79620031 NA -0.44 -6.84 -0.39 5.47e-11 Intelligence (multi-trait analysis); CESC cis rs734999 0.545 rs7368072 chr1:2556125 C/T cg20673091 chr1:2541236 MMEL1 0.48 8.03 0.44 3.11e-14 Ulcerative colitis; CESC cis rs12142240 0.698 rs1053628 chr1:46827769 C/T cg00530320 chr1:46809349 NSUN4 0.6 8.01 0.44 3.75e-14 Menopause (age at onset); CESC cis rs3126085 0.935 rs10888483 chr1:152252789 T/A cg03465714 chr1:152285911 FLG 0.49 5.43 0.32 1.24e-7 Atopic dermatitis; CESC cis rs2204008 0.654 rs1290325 chr12:38152910 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.18 -0.4 6.82e-12 Bladder cancer; CESC cis rs6546550 0.904 rs3771537 chr2:70038792 A/C cg02498382 chr2:70120550 SNRNP27 -0.36 -6.29 -0.36 1.29e-9 Prevalent atrial fibrillation; CESC cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg20503657 chr10:835505 NA 0.74 6.69 0.38 1.28e-10 Eosinophil percentage of granulocytes; CESC cis rs6009527 0.752 rs7286232 chr22:49568490 A/G cg12746016 chr22:49560550 NA 0.4 6.88 0.39 4.4e-11 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); CESC cis rs8060686 0.516 rs8044995 chr16:68189340 G/A cg26727032 chr16:67993705 SLC12A4 -0.55 -7.63 -0.42 4.17e-13 HDL cholesterol;Metabolic syndrome; CESC trans rs1814175 0.588 rs10839463 chr11:49971643 A/G cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg21951975 chr1:209979733 IRF6 0.66 9.95 0.52 5.01e-20 Cleft lip with or without cleft palate; CESC cis rs9796 0.621 rs2899013 chr15:41492283 G/T cg20272979 chr15:41787780 ITPKA 0.35 5.23 0.31 3.5e-7 Menopause (age at onset); CESC cis rs2952156 0.959 rs2941504 chr17:37830900 A/G cg07936489 chr17:37558343 FBXL20 -0.5 -6.04 -0.35 5.14e-9 Asthma; CESC cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.81 7.71 0.43 2.49e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1003719 0.591 rs9636914 chr21:38589732 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.48 6.11 0.35 3.63e-9 Eye color traits; CESC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg00277769 chr7:97922759 BAIAP2L1 0.33 5.5 0.32 9.17e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg11494091 chr17:61959527 GH2 -0.8 -15.09 -0.68 1.42e-37 Prudent dietary pattern; CESC cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg12292205 chr6:26970375 C6orf41 -0.53 -5.84 -0.34 1.53e-8 Intelligence (multi-trait analysis); CESC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg24829409 chr8:58192753 C8orf71 -0.75 -9.96 -0.52 4.74e-20 Developmental language disorder (linguistic errors); CESC cis rs9467711 0.606 rs9379863 chr6:26372427 A/G cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.07e-9 Autism spectrum disorder or schizophrenia; CESC cis rs6032067 0.929 rs17424696 chr20:43810734 G/A cg11264863 chr20:43835661 SEMG1 0.49 5.33 0.31 2.06e-7 Blood protein levels; CESC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg11494091 chr17:61959527 GH2 -0.71 -12.41 -0.61 3.42e-28 Prudent dietary pattern; CESC cis rs724767 1.000 rs724767 chr3:193722330 C/T cg01524723 chr3:193718032 NA -0.64 -6.52 -0.37 3.5e-10 Estradiol plasma levels (breast cancer); CESC cis rs7520050 0.966 rs12021587 chr1:46472759 G/T cg03146154 chr1:46216737 IPP -0.46 -5.87 -0.34 1.31e-8 Red blood cell count;Reticulocyte count; CESC cis rs2637266 0.756 rs846631 chr10:78536928 T/G cg18941641 chr10:78392320 NA 0.41 8.21 0.45 1.01e-14 Pulmonary function; CESC cis rs10510653 0.522 rs62244401 chr3:32033509 G/A cg05935571 chr3:32023257 ZNF860;OSBPL10 0.98 7.16 0.4 8.14e-12 Schizophrenia; CESC cis rs7945705 0.967 rs10840148 chr11:8923528 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.38 6.0 0.35 6.57e-9 Hemoglobin concentration; CESC cis rs2070433 1.000 rs11701310 chr21:47962836 G/C cg12379764 chr21:47803548 PCNT 0.6 6.99 0.39 2.19e-11 Lymphocyte counts; CESC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg11764359 chr7:65958608 NA 0.8 12.03 0.59 6.98e-27 Aortic root size; CESC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg04315214 chr1:2043799 PRKCZ -0.46 -7.35 -0.41 2.5e-12 Height; CESC cis rs10129255 0.518 rs8009612 chr14:107185749 G/T cg23076370 chr14:107095027 NA -0.67 -10.03 -0.52 2.81e-20 Kawasaki disease; CESC cis rs8027181 0.617 rs6495017 chr15:73089625 T/A cg25632853 chr15:73088954 NA -0.38 -5.44 -0.32 1.24e-7 Triglyceride levels; CESC cis rs11958404 0.932 rs11950297 chr5:157419938 T/G cg05962755 chr5:157440814 NA 0.63 6.75 0.38 9.02e-11 IgG glycosylation; CESC cis rs829883 0.659 rs11109520 chr12:98928646 C/T cg25150519 chr12:98850993 NA 0.65 8.0 0.44 3.78e-14 Colorectal adenoma (advanced); CESC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg24250549 chr1:154909240 PMVK 0.74 10.98 0.56 2.38e-23 Prostate cancer; CESC cis rs7216064 1.000 rs4791299 chr17:65930937 A/G cg12091567 chr17:66097778 LOC651250 -0.72 -8.28 -0.45 6.01e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg15604190 chr1:6052593 NPHP4 -0.5 -6.1 -0.35 3.75e-9 Lung cancer in ever smokers; CESC cis rs2012796 0.957 rs8016255 chr14:81816121 C/G cg02996355 chr14:81879375 NA 0.49 5.68 0.33 3.53e-8 Night sleep phenotypes; CESC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg11764359 chr7:65958608 NA -0.95 -14.42 -0.66 3.33e-35 Aortic root size; CESC cis rs244293 0.795 rs11079151 chr17:53095366 G/A cg19360675 chr17:53046073 COX11;STXBP4 0.4 5.11 0.3 6.18e-7 Menarche (age at onset); CESC cis rs73206853 0.563 rs1107652 chr12:111176213 A/G cg12870014 chr12:110450643 ANKRD13A 0.66 5.92 0.34 1e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg19622623 chr12:86230825 RASSF9 -0.45 -5.91 -0.34 1.06e-8 Major depressive disorder; CESC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg23281280 chr6:28129359 ZNF389 0.59 8.16 0.45 1.34e-14 Depression; CESC trans rs875971 1.000 rs10215948 chr7:65747786 G/A cg26939375 chr7:64535504 NA -0.45 -6.06 -0.35 4.54e-9 Aortic root size; CESC cis rs7264396 0.790 rs1040695 chr20:34244829 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.82 0.43 1.25e-13 Total cholesterol levels; CESC cis rs6062302 0.522 rs13043255 chr20:62218916 C/G cg09650180 chr20:62225654 GMEB2 -0.81 -9.29 -0.5 5.66e-18 Glioblastoma; CESC cis rs9911578 0.904 rs7209253 chr17:56908987 C/T cg12560992 chr17:57184187 TRIM37 0.94 15.75 0.7 6.57e-40 Intelligence (multi-trait analysis); CESC cis rs3733585 0.673 rs9994266 chr4:9954450 C/T cg11266682 chr4:10021025 SLC2A9 -0.6 -11.54 -0.58 3.03e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs561341 0.941 rs8066558 chr17:30272879 G/T cg19193384 chr17:30244184 NA -0.63 -6.55 -0.37 3.01e-10 Hip circumference adjusted for BMI; CESC cis rs113835537 0.529 rs57691879 chr11:66236604 C/T cg24851651 chr11:66362959 CCS 0.47 5.83 0.34 1.62e-8 Airway imaging phenotypes; CESC cis rs12477438 1.000 rs17760953 chr2:99859863 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.73 -8.78 -0.47 2.13e-16 Chronic sinus infection; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20099018 chr17:40169396 DNAJC7;NKIRAS2 0.48 6.4 0.37 6.9e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg20476274 chr7:133979776 SLC35B4 0.67 9.79 0.52 1.65e-19 Mean platelet volume; CESC cis rs1797885 1.000 rs2589673 chr3:12516501 T/C cg26432171 chr3:12704882 RAF1 -0.5 -6.47 -0.37 4.75e-10 Immature fraction of reticulocytes; CESC cis rs6964587 0.773 rs38793 chr7:92027187 A/G cg17063962 chr7:91808500 NA -0.56 -7.19 -0.4 6.44e-12 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06208661 chr6:26660150 ZNF322A -0.58 -6.2 -0.36 2.2e-9 Gut microbiome composition (summer); CESC cis rs3110496 0.685 rs550818 chr17:27901975 A/G cg00032419 chr17:27895566 TP53I13 0.52 5.43 0.32 1.3e-7 Height; CESC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg19257562 chr1:2043853 PRKCZ 0.41 6.72 0.38 1.08e-10 Height; CESC cis rs2806561 0.704 rs636940 chr1:23522967 A/T cg12483005 chr1:23474871 LUZP1 0.43 6.55 0.37 2.93e-10 Height; CESC cis rs225245 0.817 rs225284 chr17:33933006 A/C cg05299278 chr17:33885742 SLFN14 0.39 5.51 0.32 8.59e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs7618501 0.521 rs11130222 chr3:49901060 A/T cg24110177 chr3:50126178 RBM5 -0.51 -6.73 -0.38 1.06e-10 Intelligence (multi-trait analysis); CESC cis rs12530845 1.000 rs6979439 chr7:135329004 A/G cg23117316 chr7:135346802 PL-5283 -0.41 -5.29 -0.31 2.52e-7 Red blood cell traits; CESC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg05863683 chr7:1912471 MAD1L1 0.4 5.84 0.34 1.49e-8 Schizophrenia, schizoaffective disorder or bipolar disorder; CESC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg23131131 chr22:24373011 LOC391322 0.7 9.57 0.51 8.02e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6582630 0.502 rs7311700 chr12:38463232 T/A cg13010199 chr12:38710504 ALG10B 0.53 6.74 0.38 9.64e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg05343316 chr1:45956843 TESK2 -0.48 -6.08 -0.35 4.21e-9 High light scatter reticulocyte count; CESC cis rs4888262 0.526 rs7205258 chr16:74642539 C/T cg01733217 chr16:74700730 RFWD3 0.86 12.18 0.6 2.06e-27 Testicular germ cell tumor; CESC cis rs7312774 0.881 rs7297923 chr12:107305573 T/C cg16260113 chr12:107380972 MTERFD3 0.64 6.08 0.35 4.15e-9 Severe influenza A (H1N1) infection; CESC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg02569458 chr12:86230093 RASSF9 0.51 7.69 0.43 2.85e-13 Major depressive disorder; CESC cis rs4849845 0.678 rs3896632 chr2:121023496 C/T cg24070213 chr2:121070622 NA 0.45 6.48 0.37 4.45e-10 Mean platelet volume; CESC cis rs561341 0.883 rs886224 chr17:30229902 T/C cg00745463 chr17:30367425 LRRC37B -0.64 -6.26 -0.36 1.57e-9 Hip circumference adjusted for BMI; CESC cis rs8114671 0.562 rs4911449 chr20:33512236 T/G cg07148914 chr20:33460835 GGT7 0.45 5.9 0.34 1.09e-8 Height; CESC trans rs9325144 0.560 rs11182952 chr12:38636278 C/A cg23762105 chr12:34175262 ALG10 0.48 6.31 0.36 1.16e-9 Morning vs. evening chronotype; CESC cis rs9457247 0.935 rs9348211 chr6:167375173 G/C cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.66e-7 Crohn's disease; CESC cis rs1322639 0.614 rs6908401 chr6:169564716 A/C cg03254818 chr6:169586852 NA -0.49 -5.45 -0.32 1.14e-7 Pulse pressure; CESC cis rs2635047 1.000 rs2277717 chr18:44702718 C/A cg19077165 chr18:44547161 KATNAL2 -0.45 -6.12 -0.35 3.31e-9 Educational attainment; CESC cis rs9811920 0.809 rs793475 chr3:99543764 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.43 -7.02 -0.4 1.9e-11 Axial length; CESC cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg27588902 chr6:42928151 GNMT -0.27 -5.09 -0.3 6.92e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.41 7.34 0.41 2.62e-12 Bipolar disorder; CESC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg27286337 chr10:134555280 INPP5A 0.68 7.69 0.43 2.81e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg18252515 chr7:66147081 NA 0.44 5.78 0.33 2.14e-8 Aortic root size; CESC cis rs2075371 0.501 rs1646652 chr7:134024515 A/T cg20476274 chr7:133979776 SLC35B4 0.4 5.2 0.3 3.98e-7 Mean platelet volume; CESC cis rs2072499 1.000 rs2241108 chr1:156181007 C/G cg24450063 chr1:156163899 SLC25A44 1.07 22.09 0.8 5.03e-62 Testicular germ cell tumor; CESC cis rs1729951 0.546 rs12054218 chr3:136677496 C/G cg25687071 chr3:136751404 NA 0.39 5.23 0.31 3.44e-7 Neuroticism; CESC cis rs11997175 0.550 rs7459534 chr8:33836623 G/C ch.8.33884649F chr8:33765107 NA 0.59 7.16 0.4 7.74e-12 Body mass index; CESC trans rs7615952 0.932 rs13086087 chr3:125646281 A/C cg07211511 chr3:129823064 LOC729375 -1.13 -15.07 -0.68 1.8e-37 Blood pressure (smoking interaction); CESC cis rs2617583 0.904 rs2937639 chr5:1443728 A/G cg07151155 chr5:1473589 LPCAT1 -0.35 -5.37 -0.31 1.72e-7 Breast cancer; CESC cis rs412050 0.512 rs79497006 chr22:22254137 G/A cg17089214 chr22:22089827 YPEL1 0.75 5.14 0.3 5.4e-7 Attention deficit hyperactivity disorder; CESC cis rs3733585 0.673 rs4447861 chr4:9953940 C/T cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7089973 0.604 rs11196941 chr10:116596258 A/G cg25233709 chr10:116636983 FAM160B1 0.38 5.98 0.34 7.26e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg04455712 chr21:45112962 RRP1B 0.5 7.58 0.42 5.84e-13 Mean corpuscular volume; CESC cis rs14403 1.000 rs12134270 chr1:243662668 T/G cg21452805 chr1:244014465 NA 0.46 5.42 0.32 1.31e-7 Schizophrenia; CESC cis rs854765 0.647 rs7212447 chr17:17987067 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.67 0.47 4.44e-16 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07154196 chr1:29214064 EPB41 0.57 6.45 0.37 5.15e-10 Gut microbiome composition (summer); CESC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg13866156 chr1:1669148 SLC35E2 0.41 5.45 0.32 1.16e-7 Body mass index; CESC cis rs6547741 0.935 rs4666004 chr2:27855052 T/A cg21248554 chr2:27665150 KRTCAP3 0.26 5.31 0.31 2.34e-7 Oral cavity cancer; CESC cis rs826838 0.651 rs1843896 chr12:38612913 G/C cg26384229 chr12:38710491 ALG10B 0.55 8.11 0.45 1.93e-14 Heart rate; CESC cis rs7959452 0.640 rs12370042 chr12:69692420 C/G cg20891283 chr12:69753455 YEATS4 0.77 11.34 0.57 1.43e-24 Blood protein levels; CESC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07775675 chr17:74379922 SPHK1 -0.46 -6.11 -0.35 3.55e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4704187 0.663 rs6897274 chr5:74426103 T/A cg03227963 chr5:74354835 NA 0.31 5.68 0.33 3.52e-8 Response to amphetamines; CESC cis rs832540 0.519 rs10036895 chr5:56273693 G/A cg14703610 chr5:56206110 C5orf35 0.52 6.76 0.38 8.68e-11 Coronary artery disease; CESC cis rs2304069 0.954 rs216127 chr5:149428890 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.92 11.75 0.59 6.29e-26 HIV-1 control; CESC cis rs796364 0.951 rs59695400 chr2:201021325 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -6.41 -0.37 6.74e-10 Schizophrenia; CESC cis rs72772090 0.539 rs56120748 chr5:96110622 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.03 -0.3 8.86e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs72945132 0.882 rs17853270 chr11:70200529 C/T cg00319359 chr11:70116639 PPFIA1 0.78 7.27 0.41 3.99e-12 Coronary artery disease; CESC cis rs7786808 0.741 rs7789415 chr7:158227617 C/T cg01191920 chr7:158217561 PTPRN2 -0.41 -7.31 -0.41 3.1e-12 Obesity-related traits; CESC cis rs2535633 0.631 rs11915851 chr3:53096047 C/T cg07507251 chr3:52567010 NT5DC2 0.35 5.19 0.3 4.13e-7 Body mass index; CESC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg10800226 chr5:1850261 NA 0.34 5.68 0.33 3.55e-8 Cardiovascular disease risk factors; CESC cis rs4604732 0.578 rs12038656 chr1:247623816 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.1 0.3 6.5e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.56 -6.48 -0.37 4.47e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11640734 0.609 rs11647746 chr16:89806343 C/A cg04013166 chr16:89971882 TCF25 0.78 8.27 0.45 6.77e-15 Interleukin-17 levels; CESC cis rs637571 0.584 rs594689 chr11:65635559 G/A cg26695010 chr11:65641043 EFEMP2 0.59 7.37 0.41 2.14e-12 Eosinophil percentage of white cells; CESC cis rs7408868 1.000 rs7249525 chr19:15277309 G/A cg14696996 chr19:15285081 NOTCH3 1.11 11.39 0.57 1.03e-24 Pulse pressure; CESC cis rs7107174 1.000 rs4944195 chr11:78003499 T/C cg02023728 chr11:77925099 USP35 0.5 6.69 0.38 1.33e-10 Testicular germ cell tumor; CESC trans rs7246760 1.000 rs17849496 chr19:9922223 G/A cg02900749 chr2:68251473 NA -0.83 -7.08 -0.4 1.3e-11 Pursuit maintenance gain; CESC cis rs2439831 0.850 rs7179388 chr15:44123945 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.36 0.41 2.32e-12 Lung cancer in ever smokers; CESC cis rs7089973 0.604 rs1359079 chr10:116582502 A/G cg25233709 chr10:116636983 FAM160B1 0.35 5.47 0.32 1.05e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2109514 0.902 rs926197 chr7:116118330 A/C cg12739419 chr7:116140593 CAV2 0.34 6.26 0.36 1.53e-9 Prevalent atrial fibrillation; CESC cis rs9611565 0.512 rs139572 chr22:42214532 C/T cg06481639 chr22:41940642 POLR3H -0.53 -5.11 -0.3 6.3e-7 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22580712 chr15:99191230 NA -0.59 -6.79 -0.38 7.36e-11 Gut microbiome composition (summer); CESC cis rs3736485 0.934 rs4143721 chr15:51866781 A/G cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs60515486 0.527 rs10769255 chr11:47367371 C/T cg25783544 chr11:47291846 MADD 0.62 6.14 0.35 2.99e-9 Lymphocyte counts; CESC cis rs7560272 0.501 rs10191988 chr2:73947787 A/G cg20560298 chr2:73613845 ALMS1 0.42 5.68 0.33 3.57e-8 Schizophrenia; CESC cis rs8017423 0.935 rs3737035 chr14:90745422 T/C cg14092571 chr14:90743983 NA 0.56 8.5 0.46 1.42e-15 Mortality in heart failure; CESC cis rs4689388 0.926 rs1801214 chr4:6303022 C/T cg14416269 chr4:6271139 WFS1 0.47 7.91 0.44 7.13e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7824557 0.564 rs13274106 chr8:11233958 A/G cg21775007 chr8:11205619 TDH -0.52 -7.67 -0.43 3.23e-13 Retinal vascular caliber; CESC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.45 7.4 0.41 1.77e-12 Personality dimensions; CESC cis rs490234 0.616 rs2648318 chr9:128163447 T/C cg14078157 chr9:128172775 NA -0.3 -5.22 -0.31 3.56e-7 Mean arterial pressure; CESC cis rs7503807 0.967 rs12939549 chr17:78611724 C/T cg09596252 chr17:78655493 RPTOR -0.5 -7.35 -0.41 2.4e-12 Obesity; CESC cis rs12190007 0.547 rs3006184 chr6:169805128 C/T cg15038512 chr6:170123185 PHF10 -0.48 -6.81 -0.39 6.6e-11 Obesity-related traits; CESC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg13206674 chr6:150067644 NUP43 0.42 5.89 0.34 1.19e-8 Lung cancer; CESC cis rs7085104 0.572 rs284858 chr10:104573936 T/C cg04362960 chr10:104952993 NT5C2 -0.47 -6.17 -0.35 2.58e-9 Immature fraction of reticulocytes;Schizophrenia; CESC trans rs875971 0.617 rs810400 chr7:66022889 G/C cg26939375 chr7:64535504 NA -0.64 -8.7 -0.47 3.62e-16 Aortic root size; CESC cis rs3106136 0.967 rs66581998 chr4:95196901 T/C cg11021082 chr4:95130006 SMARCAD1 -0.48 -7.19 -0.4 6.65e-12 Capecitabine sensitivity; CESC cis rs58235267 0.656 rs13410889 chr2:63087778 T/C cg17519650 chr2:63277830 OTX1 0.65 9.15 0.49 1.54e-17 Prostate-specific antigen levels (conditioned on lead SNPs); CESC cis rs4925386 0.681 rs2427294 chr20:60927257 G/A cg22633769 chr20:60982531 CABLES2 0.54 5.68 0.33 3.55e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC trans rs9329221 0.506 rs17689674 chr8:9981854 C/A cg15556689 chr8:8085844 FLJ10661 0.51 6.18 0.35 2.45e-9 Neuroticism; CESC trans rs2727020 0.786 rs10839263 chr11:49354462 A/G cg03929089 chr4:120376271 NA -0.64 -7.4 -0.41 1.82e-12 Coronary artery disease; CESC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg18305652 chr10:134549665 INPP5A 0.48 7.05 0.4 1.54e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.36 -5.74 -0.33 2.54e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7178909 0.831 rs1910587 chr15:90440487 A/C cg19708238 chr15:90437601 AP3S2 0.46 6.52 0.37 3.52e-10 Common traits (Other); CESC cis rs1707322 1.000 rs4660903 chr1:46457601 A/G cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11039798 0.623 rs635632 chr11:48399532 T/C cg15704280 chr7:45808275 SEPT13 -0.69 -6.75 -0.38 9.03e-11 Axial length; CESC trans rs9561428 0.850 rs7319499 chr13:94419894 T/G cg17039369 chr21:46341006 ITGB2 0.5 6.11 0.35 3.5e-9 Bipolar disorder and schizophrenia; CESC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg03388025 chr16:89894329 SPIRE2 0.4 7.51 0.42 9.13e-13 Vitiligo; CESC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg10691866 chr7:65817282 TPST1 -0.33 -5.43 -0.32 1.3e-7 Aortic root size; CESC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs6912958 1.000 rs9294379 chr6:88152535 C/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -5.36 -0.31 1.81e-7 Monocyte percentage of white cells; CESC cis rs6500395 1.000 rs7184144 chr16:48606077 C/T cg04672837 chr16:48644449 N4BP1 0.52 6.51 0.37 3.72e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs751728 1.000 rs3806108 chr6:33767579 C/G cg15252951 chr6:33757062 LEMD2 0.47 6.02 0.35 5.76e-9 Crohn's disease; CESC cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg24130564 chr14:104152367 KLC1 -0.48 -6.36 -0.36 8.88e-10 Reticulocyte count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24686684 chr20:48330546 B4GALT5 -0.47 -6.12 -0.35 3.32e-9 Ulcerative colitis; CESC cis rs9811920 0.514 rs1287283 chr3:99515750 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.56 -8.51 -0.46 1.35e-15 Axial length; CESC cis rs2000999 0.515 rs2854956 chr16:72115238 A/T cg01557791 chr16:72042693 DHODH -0.57 -7.5 -0.42 9.36e-13 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg25272121 chr1:152190972 HRNR -0.41 -6.0 -0.35 6.32e-9 Inflammatory skin disease; CESC cis rs920590 0.684 rs59565447 chr8:19668430 A/T cg01411142 chr8:19674711 INTS10 0.55 6.1 0.35 3.65e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs7582720 1.000 rs72936834 chr2:203771260 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs2090104 0.739 rs7663339 chr4:128481449 T/C cg21894728 chr21:47453656 NA -0.4 -6.01 -0.35 6.22e-9 IgG glycosylation; CESC cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg13628971 chr7:2884303 GNA12 0.43 5.79 0.34 1.96e-8 Height; CESC cis rs7586673 1.000 rs7586673 chr2:161923520 C/A cg16506815 chr2:162101123 NA 0.43 5.89 0.34 1.16e-8 Intelligence (multi-trait analysis); CESC cis rs11864453 0.826 rs8062041 chr16:72088964 C/T cg16558253 chr16:72132732 DHX38 -0.56 -8.42 -0.46 2.4e-15 Fibrinogen levels; CESC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg18446336 chr7:2847575 GNA12 -0.34 -5.4 -0.31 1.49e-7 Height; CESC cis rs3733585 0.577 rs5014939 chr4:9953253 T/A cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs941873 0.772 rs1892498 chr10:81103862 A/G cg08514558 chr10:81106712 PPIF 0.33 5.61 0.33 5.02e-8 Height; CESC cis rs936229 0.749 rs8031937 chr15:75181121 A/G cg10253484 chr15:75165896 SCAMP2 -0.45 -5.14 -0.3 5.28e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs7044106 0.762 rs10739570 chr9:123381222 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 9.89 0.52 7.98e-20 Hip circumference adjusted for BMI; CESC cis rs921968 0.565 rs6436072 chr2:219598095 C/T cg02176678 chr2:219576539 TTLL4 -0.45 -8.06 -0.44 2.61e-14 Mean corpuscular hemoglobin concentration; CESC cis rs4319547 0.656 rs10744209 chr12:122931568 G/A cg23029597 chr12:123009494 RSRC2 -0.45 -5.08 -0.3 7.04e-7 Body mass index; CESC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.84 9.06 0.49 2.98e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs7615952 0.932 rs7630077 chr3:125649676 T/C cg07211511 chr3:129823064 LOC729375 -1.07 -14.03 -0.65 8.08e-34 Blood pressure (smoking interaction); CESC cis rs35110281 0.782 rs9981790 chr21:45045052 G/C cg21573476 chr21:45109991 RRP1B -0.47 -6.6 -0.38 2.19e-10 Mean corpuscular volume; CESC cis rs7833986 0.501 rs72653981 chr8:57027814 G/A cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.41 0.32 1.42e-7 Height; CESC cis rs748404 0.690 rs2244981 chr15:43752751 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.49 0.42 1.01e-12 Lung cancer; CESC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg12718519 chr1:2058417 PRKCZ -0.24 -5.16 -0.3 4.91e-7 Height; CESC cis rs7116495 0.609 rs501308 chr11:71581325 C/G cg26138937 chr11:71823887 C11orf51 1.15 7.68 0.43 3.09e-13 Severe influenza A (H1N1) infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22704915 chr10:73079101 SLC29A3 -0.5 -6.56 -0.37 2.81e-10 Fibrinogen levels; CESC cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg26597838 chr10:835615 NA -0.46 -5.83 -0.34 1.57e-8 Eosinophil percentage of granulocytes; CESC cis rs17001868 0.568 rs9611315 chr22:40736900 A/T cg07138101 chr22:40742427 ADSL 0.57 5.38 0.31 1.66e-7 Mammographic density (dense area); CESC cis rs16917546 1.000 rs7094595 chr10:64415413 T/A cg03961010 chr10:64397487 ZNF365 -0.38 -6.22 -0.36 1.91e-9 Basal cell carcinoma; CESC trans rs11159647 0.636 rs12431785 chr14:84729859 T/G cg19838074 chr2:242149865 ANO7 0.41 6.01 0.35 6.27e-9 Alzheimer's disease; CESC trans rs629535 0.814 rs62513378 chr8:70095788 G/C cg21567404 chr3:27674614 NA -0.86 -9.86 -0.52 9.8e-20 Dupuytren's disease; CESC cis rs11958404 0.932 rs11950881 chr5:157410550 C/T cg05962755 chr5:157440814 NA 0.56 6.16 0.35 2.74e-9 IgG glycosylation; CESC cis rs2180341 0.618 rs12529077 chr6:127634244 G/T cg27446573 chr6:127587934 RNF146 0.62 8.56 0.47 9.22e-16 Breast cancer; CESC cis rs2573652 0.755 rs6598286 chr15:100515985 G/T cg09918751 chr15:100517450 ADAMTS17 -0.43 -8.48 -0.46 1.63e-15 Height; CESC cis rs7762018 1.000 rs73242927 chr6:170129573 T/A cg13891659 chr6:170190454 C6orf122;C6orf208 0.56 5.6 0.33 5.38e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg26314531 chr2:26401878 FAM59B -0.61 -6.85 -0.39 5.26e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg03060546 chr3:49711283 APEH -0.73 -10.88 -0.56 4.83e-23 Resting heart rate; CESC cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg10556349 chr10:835070 NA 0.62 5.93 0.34 9.61e-9 Eosinophil percentage of granulocytes; CESC cis rs6674176 0.518 rs917294 chr1:44249485 A/G cg12908607 chr1:44402522 ARTN -0.4 -5.4 -0.31 1.5e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2243480 1.000 rs34637256 chr7:65360131 G/A cg13147721 chr7:65941812 NA -0.85 -8.15 -0.45 1.41e-14 Diabetic kidney disease; CESC cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg12826209 chr6:26865740 GUSBL1 0.75 8.82 0.48 1.62e-16 Intelligence (multi-trait analysis); CESC cis rs3857067 0.772 rs4692999 chr4:95107644 T/C cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.05 -0.49 3.25e-17 QT interval; CESC cis rs4906332 0.811 rs2296487 chr14:103996205 T/C cg04998671 chr14:104000505 TRMT61A -0.47 -5.63 -0.33 4.58e-8 Coronary artery disease; CESC cis rs10128251 0.746 rs9424194 chr10:5724073 A/G cg24097872 chr10:5724021 NA 0.38 5.55 0.32 6.76e-8 Childhood ear infection; CESC cis rs7274811 0.711 rs291698 chr20:31982250 A/T cg21523528 chr20:32077966 CBFA2T2 -0.45 -5.32 -0.31 2.21e-7 Height; CESC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg14829155 chr15:31115871 NA -0.76 -10.62 -0.55 3.5e-22 Huntington's disease progression; CESC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg20887711 chr4:1340912 KIAA1530 0.5 6.95 0.39 2.76e-11 Longevity; CESC cis rs75804782 0.557 rs3769118 chr2:239342542 C/G cg18131467 chr2:239335373 ASB1 -0.69 -6.69 -0.38 1.35e-10 Morning vs. evening chronotype;Chronotype; CESC cis rs616402 0.527 rs589151 chr1:10567711 C/T cg20482658 chr1:10539492 PEX14 -0.28 -5.84 -0.34 1.54e-8 Breast size; CESC trans rs7088969 0.627 rs6585460 chr10:119552567 C/T cg11827998 chr14:105995685 TMEM121 -0.41 -6.02 -0.35 5.83e-9 Homeostasis model assessment of beta-cell function (dietary factor interaction); CESC cis rs644799 0.763 rs2950521 chr11:95536870 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.61 0.38 2.07e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11970458 chr16:31213481 PYCARD 0.49 6.38 0.36 7.83e-10 Gut microbiota (bacterial taxa); CESC cis rs644799 0.965 rs534488 chr11:95562327 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.76 0.38 8.51e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg14393609 chr7:65229607 NA 0.53 7.23 0.41 5.11e-12 Aortic root size; CESC trans rs1814175 0.588 rs10466497 chr11:49864381 A/T cg15704280 chr7:45808275 SEPT13 -1.0 -18.47 -0.75 1.63e-49 Height; CESC cis rs3026101 0.671 rs1806249 chr17:5311143 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.28e-8 Body mass index; CESC trans rs208520 0.690 rs3843513 chr6:66836797 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -12.94 -0.62 5.29e-30 Exhaled nitric oxide output; CESC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg00310523 chr12:86230176 RASSF9 0.35 5.44 0.32 1.22e-7 Major depressive disorder; CESC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.93 0.52 5.7e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs66573146 0.831 rs56081162 chr4:6989718 C/T cg00086871 chr4:6988644 TBC1D14 1.18 7.59 0.42 5.52e-13 Granulocyte percentage of myeloid white cells; CESC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC cis rs1707322 0.716 rs10890342 chr1:46157087 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7837860 0.588 rs28630437 chr8:89298359 A/G cg04391754 chr17:18022714 MYO15A 0.53 6.14 0.35 2.98e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg25566285 chr7:158114605 PTPRN2 0.49 8.13 0.45 1.64e-14 Calcium levels; CESC cis rs7824557 0.564 rs7821459 chr8:11236681 T/G cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.52e-14 Retinal vascular caliber; CESC cis rs9487051 0.676 rs7775206 chr6:109597222 A/G cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC trans rs1814175 0.645 rs1851853 chr11:49953434 C/T cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs2180341 1.000 rs9388561 chr6:127634921 C/T cg27446573 chr6:127587934 RNF146 1.09 16.38 0.71 3.79e-42 Breast cancer; CESC cis rs7923452 0.938 rs34930615 chr10:30761051 G/A cg18806716 chr10:30721971 MAP3K8 0.5 6.0 0.35 6.45e-9 Itch intensity from mosquito bite; CESC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg10691866 chr7:65817282 TPST1 -0.33 -5.39 -0.31 1.58e-7 Aortic root size; CESC cis rs2249694 0.503 rs9418982 chr10:135320622 C/T cg20169779 chr10:135381914 SYCE1 0.41 5.4 0.31 1.49e-7 Obesity-related traits; CESC cis rs10789491 1.000 rs11211342 chr1:47163098 T/C cg15501359 chr1:47185051 KIAA0494 0.79 8.81 0.48 1.66e-16 Response to hepatitis C treatment; CESC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg20887711 chr4:1340912 KIAA1530 -0.84 -11.42 -0.57 8.04e-25 Longevity; CESC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg27572855 chr1:25598939 RHD 0.42 6.97 0.39 2.49e-11 Erythrocyte sedimentation rate; CESC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg24324837 chr19:49891574 CCDC155 0.5 5.97 0.34 7.77e-9 Multiple sclerosis; CESC cis rs965469 0.779 rs2236109 chr20:3286439 C/A cg25506879 chr20:3388711 C20orf194 -0.47 -5.23 -0.31 3.51e-7 IFN-related cytopenia; CESC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg14393609 chr7:65229607 NA -0.45 -6.02 -0.35 5.91e-9 Aortic root size; CESC cis rs4891159 0.757 rs11665018 chr18:74123589 C/T cg24786174 chr18:74118243 ZNF516 -0.72 -11.28 -0.57 2.31e-24 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16526961 chr12:43965849 NA -0.6 -7.71 -0.43 2.59e-13 Gut microbiome composition (summer); CESC trans rs116095464 0.614 rs62344339 chr5:252995 T/G cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.35e-11 Breast cancer; CESC cis rs7219021 0.739 rs1800632 chr17:46970509 G/A cg16584676 chr17:46985605 UBE2Z -0.64 -7.31 -0.41 3.24e-12 Schizophrenia or bipolar disorder; CESC trans rs9325144 0.600 rs7312522 chr12:38730423 A/G cg23762105 chr12:34175262 ALG10 -0.45 -6.01 -0.35 6.11e-9 Morning vs. evening chronotype; CESC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg10295955 chr4:187884368 NA -1.08 -23.01 -0.82 4.07e-65 Lobe attachment (rater-scored or self-reported); CESC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg02569458 chr12:86230093 RASSF9 0.53 7.76 0.43 1.89e-13 Major depressive disorder; CESC cis rs2952156 0.959 rs2952151 chr17:37828496 T/C cg00129232 chr17:37814104 STARD3 -0.74 -9.86 -0.52 9.77e-20 Asthma; CESC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg05368731 chr17:41323189 NBR1 0.75 9.96 0.52 4.62e-20 Menopause (age at onset); CESC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg04315214 chr1:2043799 PRKCZ -0.44 -7.18 -0.4 7.17e-12 Height; CESC cis rs3106136 0.546 rs2664881 chr4:95143484 A/G cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Capecitabine sensitivity; CESC cis rs1256061 0.646 rs1256056 chr14:64712626 A/G cg23250157 chr14:64679961 SYNE2 0.51 7.36 0.41 2.3e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7703051 0.775 rs7702895 chr5:74612893 G/A cg03227963 chr5:74354835 NA 0.28 5.1 0.3 6.48e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs888194 0.934 rs3742015 chr12:110017125 T/C cg19025524 chr12:109796872 NA -0.35 -5.24 -0.31 3.3e-7 Neuroticism; CESC cis rs9908102 0.746 rs8071456 chr17:12914458 C/A cg26162695 chr17:12921313 ELAC2 0.52 5.66 0.33 4.01e-8 Schizophrenia; CESC trans rs9330316 0.609 rs7579996 chr2:110371692 C/A cg02059952 chr17:8384595 MYH10 -0.49 -6.06 -0.35 4.66e-9 Schizophrenia; CESC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg18099408 chr3:52552593 STAB1 -0.32 -5.4 -0.31 1.46e-7 Electroencephalogram traits; CESC cis rs9457247 1.000 rs10946199 chr6:167404492 G/A cg25258033 chr6:167368657 RNASET2 0.39 5.9 0.34 1.13e-8 Crohn's disease; CESC cis rs1552244 0.554 rs7638846 chr3:10048601 A/G cg00149659 chr3:10157352 C3orf10 0.53 6.5 0.37 3.93e-10 Alzheimer's disease; CESC cis rs11190604 1.000 rs74650218 chr10:102293830 C/T cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs807669 0.903 rs1780640 chr22:19174597 C/T cg02655711 chr22:19163373 SLC25A1 0.97 15.0 0.68 2.98e-37 Metabolite levels; CESC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg13628971 chr7:2884303 GNA12 0.61 7.69 0.43 2.95e-13 Height; CESC cis rs2243480 0.901 rs57126451 chr7:65416306 T/C cg25894440 chr7:65020034 NA -0.63 -5.53 -0.32 7.48e-8 Diabetic kidney disease; CESC cis rs7149337 0.869 rs7159770 chr14:51691835 G/A cg23942311 chr14:51606299 NA 0.47 7.77 0.43 1.78e-13 Cancer; CESC cis rs9584850 0.874 rs3742137 chr13:99102449 C/T cg22223119 chr13:99095684 FARP1 -0.37 -5.22 -0.31 3.63e-7 Neuroticism; CESC cis rs7666738 0.579 rs7672718 chr4:98645122 A/G cg17366294 chr4:99064904 C4orf37 0.53 6.6 0.38 2.26e-10 Colonoscopy-negative controls vs population controls; CESC cis rs11958404 0.858 rs72818142 chr5:157474934 C/T cg05962755 chr5:157440814 NA 0.62 7.22 0.41 5.45e-12 IgG glycosylation; CESC cis rs6426558 0.502 rs6697665 chr1:227474665 T/C cg10327440 chr1:227177885 CDC42BPA 0.48 6.02 0.35 5.76e-9 Neutrophil percentage of white cells; CESC cis rs61996546 0.622 rs34916314 chr15:26833559 A/G cg14859324 chr15:26874363 GABRB3 -0.38 -5.1 -0.3 6.45e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs713587 0.713 rs1982200 chr2:25205427 C/T cg01884057 chr2:25150051 NA -0.37 -6.94 -0.39 2.96e-11 Body mass index in non-asthmatics; CESC cis rs12545109 0.800 rs2670055 chr8:57421575 T/C cg09654669 chr8:57350985 NA -0.45 -6.11 -0.35 3.5e-9 Obesity-related traits; CESC cis rs3733585 0.579 rs4235353 chr4:10122934 C/T cg00071950 chr4:10020882 SLC2A9 -0.65 -9.64 -0.51 4.77e-19 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6662572 0.806 rs11211133 chr1:45991079 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.53 5.85 0.34 1.48e-8 Blood protein levels; CESC cis rs6502050 0.835 rs4789731 chr17:80145904 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.48 -0.37 4.56e-10 Life satisfaction; CESC cis rs2243480 1.000 rs313814 chr7:65503293 C/A cg25894440 chr7:65020034 NA -0.62 -5.24 -0.31 3.26e-7 Diabetic kidney disease; CESC cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.68 0.47 4.24e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.673 rs4131618 chr17:29204801 C/T cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17004975 chr10:81743287 NA 0.43 6.43 0.37 6.06e-10 Fibrinogen levels; CESC cis rs9399135 0.967 rs6902438 chr6:135336587 C/T cg22676075 chr6:135203613 NA 0.52 7.42 0.41 1.61e-12 Red blood cell count; CESC cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg23711669 chr6:146136114 FBXO30 0.94 12.32 0.6 7.27e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs12477438 0.765 rs2309520 chr2:99570477 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.61 8.58 0.47 8.15e-16 Chronic sinus infection; CESC cis rs2412488 0.853 rs12507739 chr4:54352768 C/T cg22241045 chr4:54363911 LNX1 0.38 5.29 0.31 2.54e-7 DNA methylation (variation); CESC cis rs7617773 0.780 rs11706277 chr3:48360433 A/G cg20734569 chr3:48348370 SPINK8 -0.4 -5.37 -0.31 1.69e-7 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg27337021 chr5:139947627 SLC35A4 0.46 6.01 0.35 5.98e-9 Ulcerative colitis; CESC cis rs9443645 0.527 rs9359360 chr6:79702796 C/T cg05283184 chr6:79620031 NA -0.36 -5.17 -0.3 4.64e-7 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg25072359 chr17:41440525 NA 0.45 6.03 0.35 5.61e-9 Menopause (age at onset); CESC cis rs7937682 0.960 rs480293 chr11:111469132 A/C cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs2274273 0.840 rs2341622 chr14:55737243 C/A cg04306507 chr14:55594613 LGALS3 0.29 5.59 0.33 5.51e-8 Protein biomarker; CESC trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg15556689 chr8:8085844 FLJ10661 0.49 6.15 0.35 2.8e-9 Retinal vascular caliber; CESC cis rs2380220 0.574 rs7766765 chr6:95997362 G/A cg04719120 chr6:96025338 MANEA 0.47 5.39 0.31 1.6e-7 Behavioural disinhibition (generation interaction); CESC cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg12193833 chr17:30244370 NA -0.76 -6.94 -0.39 2.92e-11 Hip circumference adjusted for BMI; CESC cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg26116260 chr4:7069785 GRPEL1 0.99 14.35 0.66 5.85e-35 Monocyte percentage of white cells; CESC cis rs1400745 0.718 rs1200414 chr14:35330893 G/A cg16230307 chr14:35515116 FAM177A1 0.45 5.2 0.3 4.05e-7 Monocyte count; CESC cis rs909674 0.662 rs2899318 chr22:39837625 A/G cg01416388 chr22:39784598 NA -0.62 -7.64 -0.42 4.05e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1707322 0.752 rs12024590 chr1:46127496 A/C cg06784218 chr1:46089804 CCDC17 0.41 7.12 0.4 1.04e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg18016565 chr1:150552671 MCL1 -0.42 -6.96 -0.39 2.64e-11 Tonsillectomy; CESC cis rs1348850 0.914 rs4893950 chr2:178304885 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.88 12.63 0.61 5.96e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2243480 1.000 rs56985706 chr7:65394562 C/T cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg17158414 chr2:27665306 KRTCAP3 0.32 6.14 0.35 2.98e-9 Total body bone mineral density; CESC cis rs1568889 0.592 rs11828877 chr11:28384030 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.54 5.33 0.31 2.1e-7 Bipolar disorder; CESC cis rs7089973 0.966 rs12772800 chr10:116630962 A/G cg23260525 chr10:116636907 FAM160B1 0.37 6.08 0.35 4.22e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19552494 chr11:60674271 PRPF19 -0.43 -6.03 -0.35 5.56e-9 Gambling; CESC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg08109568 chr15:31115862 NA -0.71 -9.63 -0.51 5.02e-19 Huntington's disease progression; CESC cis rs30380 0.632 rs27434 chr5:96129512 A/G cg16492584 chr5:96139282 ERAP1 -0.48 -6.82 -0.39 6.04e-11 Cerebrospinal fluid biomarker levels; CESC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg11663144 chr21:46675770 NA -0.64 -10.11 -0.53 1.55e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs763121 0.853 rs1043441 chr22:39130964 C/T cg06022373 chr22:39101656 GTPBP1 0.89 14.59 0.67 8.89e-36 Menopause (age at onset); CESC cis rs2070488 0.965 rs7372386 chr3:38484175 C/G cg24069376 chr3:38537580 EXOG 0.46 8.19 0.45 1.15e-14 Electrocardiographic conduction measures; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.14.1124768F chr14:75910539 JDP2 -0.66 -8.3 -0.45 5.3e-15 Gut microbiome composition (summer); CESC cis rs7818688 1.000 rs10110635 chr8:96025069 C/A cg16049864 chr8:95962084 TP53INP1 0.6 5.76 0.33 2.31e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs4654899 0.796 rs77366434 chr1:21520069 C/T cg05370193 chr1:21551575 ECE1 0.45 7.03 0.4 1.76e-11 Superior frontal gyrus grey matter volume; CESC cis rs9894429 0.716 rs7405578 chr17:79588306 C/A cg21984481 chr17:79567631 NPLOC4 -0.57 -9.34 -0.5 4.18e-18 Eye color traits; CESC cis rs611744 0.839 rs672552 chr8:109164223 A/G cg21045802 chr8:109455806 TTC35 0.45 5.49 0.32 9.39e-8 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10082991 chr5:175964280 RNF44 -0.64 -7.4 -0.41 1.78e-12 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs9323289 chr14:56106784 G/C cg01858014 chr14:56050164 KTN1 -0.85 -7.03 -0.4 1.73e-11 Putamen volume; CESC cis rs9902453 1.000 rs4239227 chr17:28389103 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.87 -0.44 9.09e-14 Coffee consumption (cups per day); CESC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg23248424 chr5:179741104 GFPT2 -0.7 -9.8 -0.52 1.47e-19 Height; CESC cis rs9581857 0.547 rs9579087 chr13:28059780 G/A cg01674679 chr13:27998804 GTF3A -0.64 -5.34 -0.31 2.03e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg24675658 chr1:53192096 ZYG11B -0.52 -6.6 -0.38 2.19e-10 Monocyte count; CESC cis rs4253772 0.638 rs6007845 chr22:46718417 A/T cg18190219 chr22:46762943 CELSR1 0.4 5.27 0.31 2.86e-7 LDL cholesterol;Cholesterol, total; CESC cis rs3091242 0.933 rs9438904 chr1:25756860 T/C cg03538708 chr1:25844672 NA -0.41 -6.25 -0.36 1.67e-9 Erythrocyte sedimentation rate; CESC cis rs62005083 1.000 rs55714624 chr14:74483344 C/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.69 5.12 0.3 6.01e-7 Mean corpuscular volume; CESC cis rs7824557 0.767 rs2164273 chr8:11168499 A/G cg21775007 chr8:11205619 TDH 0.47 6.79 0.39 7.18e-11 Retinal vascular caliber; CESC cis rs8111998 0.826 rs16999362 chr19:22764825 A/C cg19914732 chr19:22715077 NA -0.37 -5.09 -0.3 6.68e-7 Corneal structure; CESC trans rs11098499 0.954 rs12507964 chr4:120413061 T/A cg25214090 chr10:38739885 LOC399744 0.72 10.08 0.53 1.97e-20 Corneal astigmatism; CESC cis rs208520 0.770 rs2224422 chr6:66883993 G/A cg07460842 chr6:66804631 NA -0.94 -12.15 -0.6 2.75e-27 Exhaled nitric oxide output; CESC cis rs7617773 0.817 rs13094727 chr3:48323489 G/A cg11946769 chr3:48343235 NME6 0.88 11.71 0.58 8.57e-26 Coronary artery disease; CESC cis rs1003719 0.715 rs9974494 chr21:38566566 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.27 -0.45 6.41e-15 Eye color traits; CESC cis rs933688 0.938 rs7720235 chr5:90659329 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.19 16.79 0.72 1.39e-43 Smoking behavior; CESC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg27121462 chr16:89883253 FANCA 0.74 10.32 0.54 3.3e-21 Vitiligo; CESC cis rs9815354 1.000 rs1716669 chr3:41908681 A/G cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7662987 0.517 rs2602883 chr4:100040914 A/T cg13256891 chr4:100009986 ADH5 0.74 7.89 0.44 7.94e-14 Smoking initiation; CESC cis rs7264396 0.563 rs6060558 chr20:34271092 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.9 -9.83 -0.52 1.23e-19 Total cholesterol levels; CESC cis rs7301826 0.651 rs7971046 chr12:131286807 G/A cg11011512 chr12:131303247 STX2 0.47 5.85 0.34 1.48e-8 Plasma plasminogen activator levels; CESC cis rs28374715 0.532 rs28584379 chr15:41670408 C/G cg18705301 chr15:41695430 NDUFAF1 -1.08 -17.72 -0.74 7.19e-47 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14899563 chr17:80656473 RAB40B 0.66 7.8 0.43 1.4e-13 Gut microbiome composition (summer); CESC cis rs681343 1.000 rs516246 chr19:49206172 C/T cg21064579 chr19:49206444 FUT2 0.52 7.35 0.41 2.4e-12 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CESC cis rs3820068 0.603 rs6660234 chr1:15962590 T/C cg16988262 chr1:15930761 NA 0.34 5.48 0.32 9.82e-8 Systolic blood pressure; CESC cis rs7561273 0.609 rs10189243 chr2:24293756 C/T cg20701182 chr2:24300061 SF3B14 0.45 6.03 0.35 5.41e-9 Quantitative traits; CESC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.85 12.03 0.59 6.76e-27 Alzheimer's disease; CESC cis rs3820068 0.705 rs4646109 chr1:15817319 T/C cg17385448 chr1:15911702 AGMAT 0.41 6.43 0.37 5.93e-10 Systolic blood pressure; CESC cis rs12142240 0.698 rs79490411 chr1:46813568 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.45 0.42 1.31e-12 Menopause (age at onset); CESC cis rs13385 0.769 rs9042 chr5:139625347 A/C cg26211634 chr5:139558579 C5orf32 0.49 5.36 0.31 1.86e-7 Atrial fibrillation; CESC cis rs34779708 0.801 rs12246600 chr10:35538121 A/C cg03585969 chr10:35415529 CREM 0.57 6.57 0.37 2.6200000000000003e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs561341 1.000 rs55959993 chr17:30254771 C/G cg19193384 chr17:30244184 NA -0.7 -6.41 -0.37 6.77e-10 Hip circumference adjusted for BMI; CESC cis rs477692 0.699 rs471357 chr10:131389373 C/G cg05714579 chr10:131428358 MGMT 0.47 6.16 0.35 2.74e-9 Response to temozolomide; CESC cis rs8077889 0.826 rs60085355 chr17:41847415 T/C cg26893861 chr17:41843967 DUSP3 0.74 8.79 0.48 1.87e-16 Triglycerides; CESC cis rs3796352 1.000 rs13072457 chr3:53102389 G/A cg12962167 chr3:53033115 SFMBT1 0.7 6.17 0.35 2.6e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs2985684 0.841 rs2281836 chr14:50065717 G/C cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.45 -5.35 -0.31 1.92e-7 Carotid intima media thickness; CESC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg08392591 chr16:89556376 ANKRD11 0.4 5.1 0.3 6.46e-7 Multiple myeloma (IgH translocation); CESC cis rs11122272 0.735 rs2250704 chr1:231486647 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.06 -0.4 1.44e-11 Hemoglobin concentration; CESC cis rs55728055 0.661 rs7293143 chr22:32013365 A/G cg01338084 chr22:32026380 PISD -1.03 -7.29 -0.41 3.65e-12 Age-related hearing impairment; CESC cis rs7666738 0.830 rs62318470 chr4:98925846 A/C cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.908 rs73677573 chr7:12283598 G/A cg20607287 chr7:12443886 VWDE -0.57 -6.07 -0.35 4.48e-9 Coronary artery disease; CESC cis rs7116495 0.786 rs1573501 chr11:71735693 C/T cg18441811 chr11:71824068 C11orf51 -0.86 -5.19 -0.3 4.21e-7 Severe influenza A (H1N1) infection; CESC cis rs36051895 0.589 rs7869015 chr9:5199750 C/T cg02405213 chr9:5042618 JAK2 -0.58 -7.15 -0.4 8.26e-12 Pediatric autoimmune diseases; CESC cis rs1048257 0.553 rs2819421 chr14:105408811 A/G cg14403583 chr14:105418241 AHNAK2 -0.57 -7.87 -0.44 9.27e-14 Systemic lupus erythematosus; CESC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.38 -6.13 -0.35 3.15e-9 Cystic fibrosis severity; CESC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.53 7.26 0.41 4.23e-12 Lymphocyte counts; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08907850 chr10:1094976 IDI1 -0.43 -6.29 -0.36 1.29e-9 Gambling; CESC cis rs116095464 0.558 rs61689490 chr5:224904 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.72 -0.47 3.15e-16 Breast cancer; CESC cis rs9828933 1.000 rs1060897 chr3:63997872 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.53 5.78 0.33 2.07e-8 Type 2 diabetes; CESC cis rs734999 0.588 rs4648562 chr1:2535613 C/A cg20673091 chr1:2541236 MMEL1 0.43 7.16 0.4 7.78e-12 Ulcerative colitis; CESC trans rs7672847 0.547 rs73864703 chr4:170434337 C/A cg19308436 chr1:237949471 RYR2 0.64 6.86 0.39 4.99e-11 Subjective well-being; CESC cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg13877915 chr19:58951672 ZNF132 -0.35 -5.32 -0.31 2.16e-7 Uric acid clearance; CESC cis rs66573146 0.831 rs6851488 chr4:6987412 C/T cg00086871 chr4:6988644 TBC1D14 1.11 8.24 0.45 8.17e-15 Granulocyte percentage of myeloid white cells; CESC cis rs11722228 0.522 rs7662229 chr4:10133014 A/T cg14348967 chr4:10160060 NA -0.39 -5.06 -0.3 7.9e-7 Gout;Urate levels;Serum uric acid levels; CESC cis rs854765 0.583 rs4534911 chr17:17852330 A/G cg04398451 chr17:18023971 MYO15A -0.7 -9.67 -0.51 3.92e-19 Total body bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26820922 chr2:32503023 YIPF4 -0.47 -6.79 -0.38 7.37e-11 Gut microbiota (bacterial taxa); CESC cis rs9393777 0.513 rs9379893 chr6:26584668 A/G cg12826209 chr6:26865740 GUSBL1 -0.63 -7.18 -0.4 7.13e-12 Intelligence (multi-trait analysis); CESC cis rs8044868 0.586 rs7190994 chr16:72099241 T/A cg01557791 chr16:72042693 DHODH -0.43 -5.89 -0.34 1.17e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7481584 0.962 rs11603638 chr11:2990526 G/A cg25174290 chr11:3078921 CARS -0.51 -6.24 -0.36 1.75e-9 Calcium levels; CESC cis rs1355223 0.902 rs680727 chr11:34704446 A/C cg11058730 chr11:34937778 PDHX;APIP 0.49 6.62 0.38 1.99e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2832191 0.740 rs6516890 chr21:30476812 T/A cg08807101 chr21:30365312 RNF160 0.76 11.01 0.56 1.88e-23 Dental caries; CESC cis rs3026101 0.587 rs8066000 chr17:5310033 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs2742234 0.541 rs61845684 chr10:43744983 T/C cg15436174 chr10:43711423 RASGEF1A 0.46 5.33 0.31 2.14e-7 Hirschsprung disease; CESC cis rs2637266 1.000 rs4979784 chr10:78355476 T/A cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.76 9.54 0.51 1e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4144743 0.941 rs10438782 chr17:45323892 G/A cg18085866 chr17:45331354 ITGB3 -0.66 -7.64 -0.43 3.87e-13 Body mass index; CESC cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg10792982 chr14:105748885 BRF1 0.43 5.67 0.33 3.65e-8 Mean platelet volume;Platelet distribution width; CESC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg05552183 chr6:42928497 GNMT 0.75 11.18 0.57 4.84e-24 Alzheimer's disease in APOE e4+ carriers; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg27304813 chr3:120068385 LRRC58 -0.45 -5.99 -0.35 6.64e-9 Height; CESC cis rs1348850 0.914 rs1374437 chr2:178363423 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.86 12.28 0.6 9.65e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4692589 0.802 rs1480542 chr4:170953614 C/T cg19918862 chr4:170955249 NA 0.43 6.62 0.38 2e-10 Anxiety disorder; CESC trans rs11039798 0.660 rs717897 chr11:48375604 A/G cg15704280 chr7:45808275 SEPT13 -0.62 -6.13 -0.35 3.22e-9 Axial length; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16555184 chr1:149982714 OTUD7B 0.61 6.76 0.38 8.66e-11 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg18876405 chr7:65276391 NA 0.49 6.51 0.37 3.76e-10 Aortic root size; CESC cis rs2066819 1.000 rs2066818 chr12:56753822 C/A cg26714650 chr12:56694279 CS -1.39 -9.05 -0.49 3.12e-17 Psoriasis vulgaris; CESC cis rs1577917 1.000 rs1995688 chr6:86632319 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -5.53 -0.32 7.75e-8 Response to antipsychotic treatment; CESC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg00149659 chr3:10157352 C3orf10 0.7 8.47 0.46 1.68e-15 Alzheimer's disease; CESC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.13 0.4 9.67e-12 Electroencephalogram traits; CESC cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs4843747 0.671 rs28465438 chr16:88103714 G/A cg17633681 chr16:88106987 BANP 0.71 9.35 0.5 3.79e-18 Menopause (age at onset); CESC cis rs870825 0.616 rs28463742 chr4:185611005 G/A cg04058563 chr4:185651563 MLF1IP 0.67 7.38 0.41 2.09e-12 Blood protein levels; CESC cis rs864537 0.646 rs1773542 chr1:167432949 T/C cg09179987 chr1:167433047 CD247 0.53 8.2 0.45 1.07e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14457132 chr6:7389888 CAGE1;RIOK1 -0.48 -6.0 -0.35 6.56e-9 Ulcerative colitis; CESC cis rs10870270 1.000 rs7078692 chr10:133775370 T/A cg08754478 chr10:133766260 PPP2R2D -0.59 -7.57 -0.42 6.29e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs7618501 1.000 rs11716575 chr3:49744890 A/G cg21659725 chr3:3221576 CRBN -0.82 -13.57 -0.64 3.35e-32 Intelligence (multi-trait analysis); CESC cis rs4535700 0.504 rs66528253 chr7:55996763 C/T cg09872392 chr7:56161020 PHKG1 0.41 5.86 0.34 1.41e-8 Macular telangiectasia type 2; CESC trans rs561341 1.000 rs72823785 chr17:30273784 C/T cg20587970 chr11:113659929 NA -1.44 -18.65 -0.75 3.63e-50 Hip circumference adjusted for BMI; CESC cis rs2011503 1.000 rs1036215 chr19:19657198 C/T cg11584989 chr19:19387371 SF4 0.56 5.96 0.34 8.06e-9 Bipolar disorder; CESC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.17e-9 Menopause (age at onset); CESC cis rs11871801 1.000 rs78594996 chr17:40570109 A/G cg21433558 chr17:40837037 CNTNAP1 0.46 5.12 0.3 5.77e-7 Crohn's disease; CESC cis rs561341 0.629 rs7216107 chr17:30224419 G/A cg13647721 chr17:30228624 UTP6 0.73 9.24 0.49 8.1e-18 Hip circumference adjusted for BMI; CESC cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg05347473 chr6:146136440 FBXO30 0.57 7.21 0.4 5.99e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7831492 0.564 rs6981979 chr8:41612255 C/T cg17182837 chr8:41585554 ANK1 -0.42 -6.42 -0.37 6.25e-10 Colorectal cancer; CESC cis rs2898290 0.540 rs12677146 chr8:11450737 C/G cg21775007 chr8:11205619 TDH -0.46 -6.7 -0.38 1.25e-10 Systolic blood pressure; CESC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg26314531 chr2:26401878 FAM59B -0.77 -8.56 -0.47 9.38e-16 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14413721 chr9:86322043 UBQLN1 -0.59 -6.6 -0.38 2.25e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7980687 0.628 rs1727332 chr12:123718301 C/T cg19016782 chr12:123741754 C12orf65 -0.37 -5.49 -0.32 9.58e-8 Height;Educational attainment;Head circumference (infant); CESC cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg17971929 chr21:40555470 PSMG1 0.71 7.24 0.41 4.94e-12 Cognitive function; CESC cis rs735396 1.000 rs1169311 chr12:121440731 C/T cg25281562 chr12:121454272 C12orf43 0.39 5.08 0.3 7.26e-7 N-glycan levels; CESC cis rs1124769 0.871 rs2619695 chr15:51160090 C/G cg21246271 chr15:51200259 AP4E1 0.54 5.15 0.3 5.16e-7 Cognitive performance; CESC cis rs8103278 0.864 rs2070737 chr19:46282890 A/T cg14061069 chr19:46274453 DMPK -0.4 -5.44 -0.32 1.22e-7 Coronary artery disease; CESC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg17372223 chr3:52568218 NT5DC2 0.39 5.6 0.33 5.45e-8 Bipolar disorder; CESC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs62005083 1.000 rs56073585 chr14:74490045 C/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.69 5.12 0.3 6.01e-7 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14748682 chr11:6624841 ILK;RRP8 0.61 6.52 0.37 3.45e-10 Gut microbiome composition (summer); CESC cis rs36051895 0.623 rs7043634 chr9:5263146 G/A cg02405213 chr9:5042618 JAK2 -0.55 -6.72 -0.38 1.1e-10 Pediatric autoimmune diseases; CESC cis rs854765 0.964 rs854813 chr17:18003845 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.46 -6.09 -0.35 3.92e-9 Total body bone mineral density; CESC cis rs3008870 1.000 rs12117131 chr1:67451922 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -14.57 -0.67 9.76e-36 Lymphocyte percentage of white cells; CESC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.62 6.09 0.35 3.88e-9 Cerebrospinal P-tau181p levels; CESC cis rs9611565 0.694 rs7285041 chr22:41829149 G/T cg06634786 chr22:41940651 POLR3H 0.71 7.08 0.4 1.28e-11 Vitiligo; CESC cis rs2228479 0.717 rs2286392 chr16:89809549 A/G cg06558623 chr16:89946397 TCF25 0.79 7.45 0.42 1.32e-12 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05446253 chr17:73498127 CASKIN2 -0.53 -6.03 -0.35 5.34e-9 Gut microbiome composition (summer); CESC cis rs826838 1.000 rs11168676 chr12:38977304 A/G cg26384229 chr12:38710491 ALG10B 0.82 14.24 0.66 1.47e-34 Heart rate; CESC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg17650747 chr5:1873721 NA 0.41 5.69 0.33 3.31e-8 Cardiovascular disease risk factors; CESC trans rs10751667 0.961 rs7480178 chr11:927108 T/C cg00159523 chr10:114713187 TCF7L2 -0.41 -6.13 -0.35 3.1e-9 Alzheimer's disease (late onset); CESC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg03709012 chr19:19516395 GATAD2A 0.95 13.98 0.65 1.22e-33 Tonsillectomy; CESC cis rs7188861 0.813 rs1794021 chr16:11377234 G/A cg01510278 chr16:11456238 NA 0.33 5.18 0.3 4.49e-7 HDL cholesterol; CESC cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg21573476 chr21:45109991 RRP1B -0.56 -8.01 -0.44 3.56e-14 Mean corpuscular volume; CESC cis rs12579753 0.917 rs76240969 chr12:82195236 C/A cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs959260 1.000 rs2033608 chr17:73367208 T/C cg12999837 chr17:73267436 MIF4GD -0.51 -5.73 -0.33 2.73e-8 Systemic lupus erythematosus; CESC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg05564831 chr3:52568323 NT5DC2 0.45 6.78 0.38 7.86e-11 Bipolar disorder; CESC cis rs12995491 1.000 rs12995491 chr2:88527414 C/T cg18490616 chr2:88469792 THNSL2 0.51 7.69 0.43 2.86e-13 Response to metformin (IC50); CESC cis rs9611565 0.765 rs132905 chr22:41799106 C/A cg06634786 chr22:41940651 POLR3H 0.71 7.51 0.42 9.15e-13 Vitiligo; CESC cis rs12681288 0.792 rs4735972 chr8:998618 A/C cg04851639 chr8:1020857 NA -0.29 -6.55 -0.37 2.9e-10 Schizophrenia; CESC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg18099408 chr3:52552593 STAB1 -0.32 -5.19 -0.3 4.2e-7 Bipolar disorder; CESC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg08859206 chr1:53392774 SCP2 -0.67 -9.86 -0.52 9.57e-20 Monocyte count; CESC cis rs11642862 1.000 rs75231191 chr16:30788601 C/T cg02466173 chr16:30829666 NA -0.59 -5.92 -0.34 9.76e-9 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12037538 chr1:25664880 TMEM50A -0.66 -7.52 -0.42 8.47e-13 Gut microbiome composition (summer); CESC cis rs6088580 0.561 rs3761147 chr20:32996689 G/T cg06115741 chr20:33292138 TP53INP2 -0.45 -5.72 -0.33 2.85e-8 Glomerular filtration rate (creatinine); CESC trans rs10838801 1 rs10838801 chr11:48098280 G/A cg15704280 chr7:45808275 SEPT13 -0.71 -9.29 -0.5 6.03e-18 Height; CESC trans rs73568641 0.583 rs73572674 chr6:154098476 A/G cg08374472 chr16:87445639 ZCCHC14 -0.45 -6.13 -0.35 3.22e-9 Methadone dose in opioid dependence; CESC cis rs9487051 0.676 rs9374077 chr6:109600194 C/T cg01475377 chr6:109611718 NA -0.43 -6.82 -0.39 6.19e-11 Reticulocyte fraction of red cells; CESC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg02951883 chr7:2050386 MAD1L1 -0.41 -5.44 -0.32 1.18e-7 Schizophrenia; CESC cis rs9868809 0.772 rs12107418 chr3:48689787 A/G cg07636037 chr3:49044803 WDR6 -0.73 -6.57 -0.37 2.71e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs1882538 0.901 rs35284403 chr7:132948884 T/C cg10665199 chr7:133106180 EXOC4 0.51 6.23 0.36 1.82e-9 Intelligence (multi-trait analysis); CESC cis rs7131987 0.903 rs11050163 chr12:29420398 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -5.51 -0.32 8.63e-8 QT interval; CESC cis rs7980687 0.627 rs1727325 chr12:123698332 G/C cg00376283 chr12:123451042 ABCB9 0.7 8.83 0.48 1.41e-16 Height;Educational attainment;Head circumference (infant); CESC cis rs6691722 0.543 rs12034846 chr1:24699589 G/A cg02336364 chr1:24764700 NIPAL3 0.35 7.07 0.4 1.41e-11 Response to interferon beta in multiple sclerosis; CESC cis rs4803468 0.967 rs892044 chr19:41903671 A/G cg14132834 chr19:41945861 ATP5SL -0.61 -7.74 -0.43 2.09e-13 Height; CESC cis rs62084913 0.511 rs895690 chr17:72784649 C/T cg25054828 chr17:72772726 NAT9;TMEM104 0.52 7.32 0.41 3.03e-12 Breast cancer; CESC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg21963583 chr11:68658836 MRPL21 0.4 5.66 0.33 3.88e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg19592336 chr6:28129416 ZNF389 0.51 6.92 0.39 3.39e-11 Depression; CESC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.73 0.38 1.02e-10 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24557248 chr1:155990769 SSR2 0.63 7.19 0.4 6.63e-12 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12655452 chr1:77685094 PIGK -0.49 -6.42 -0.37 6.42e-10 Fibrinogen levels; CESC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg18016565 chr1:150552671 MCL1 0.34 5.28 0.31 2.67e-7 Tonsillectomy; CESC cis rs2274273 0.638 rs11622636 chr14:55647840 C/T cg04306507 chr14:55594613 LGALS3 0.31 5.3 0.31 2.42e-7 Protein biomarker; CESC cis rs7107770 0.739 rs4936994 chr11:125081440 G/C cg27629782 chr11:125073726 PKNOX2 0.34 5.06 0.3 7.96e-7 Photic sneeze reflex; CESC cis rs7267979 1.000 rs6115140 chr20:25285507 C/A cg08601574 chr20:25228251 PYGB 0.37 5.2 0.3 3.93e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs12971120 1.000 rs734559 chr18:72179579 G/A cg26446133 chr18:72167187 CNDP2 -0.75 -9.67 -0.51 3.83e-19 Refractive error; CESC cis rs733592 0.507 rs7304428 chr12:48494275 T/G cg04545296 chr12:48745243 ZNF641 -0.29 -5.37 -0.31 1.69e-7 Plateletcrit; CESC trans rs4689592 0.503 rs59640165 chr4:7051661 G/A cg07817883 chr1:32538562 TMEM39B 0.68 6.45 0.37 5.33e-10 Monocyte percentage of white cells; CESC cis rs9926296 0.632 rs1800286 chr16:89869761 T/C cg27121462 chr16:89883253 FANCA 0.56 6.57 0.37 2.66e-10 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10205151 chr7:931109 C7orf20 0.48 6.43 0.37 6.01e-10 Fibrinogen levels; CESC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg19774624 chr17:42201019 HDAC5 -0.67 -10.02 -0.52 3.09e-20 Bone mineral density (hip);Bone mineral density; CESC cis rs6723226 0.766 rs398290 chr2:32503526 T/C cg02381751 chr2:32503542 YIPF4 0.9 12.99 0.62 3.45e-30 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07610776 chr16:1832675 SPSB3;NUBP2 -0.42 -6.13 -0.35 3.22e-9 Gambling; CESC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg11890956 chr21:40555474 PSMG1 -0.65 -8.96 -0.48 5.81e-17 Menarche (age at onset); CESC cis rs748404 0.631 rs4296223 chr15:43645246 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.78 0.43 1.64e-13 Lung cancer; CESC cis rs6693567 0.565 rs12093148 chr1:150265173 G/A cg09579323 chr1:150459698 TARS2 -0.48 -5.93 -0.34 9.32e-9 Migraine; CESC cis rs4243830 0.522 rs11122086 chr1:6601246 T/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.99 -9.93 -0.52 5.89e-20 Body mass index; CESC cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg16325326 chr1:53192061 ZYG11B -0.7 -11.18 -0.57 4.87e-24 Monocyte count; CESC cis rs4664304 0.629 rs62175466 chr2:160852308 C/T cg03641300 chr2:160917029 PLA2R1 -0.43 -5.8 -0.34 1.86e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs9486715 0.867 rs3860243 chr6:96905303 T/G cg06623918 chr6:96969491 KIAA0776 0.93 14.55 0.67 1.23e-35 Headache; CESC cis rs734999 0.505 rs60687045 chr1:2539603 G/A cg18854424 chr1:2615690 NA 0.29 5.69 0.33 3.33e-8 Ulcerative colitis; CESC trans rs1814175 0.645 rs1851845 chr11:49982396 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg12311346 chr5:56204834 C5orf35 0.45 5.85 0.34 1.48e-8 Coronary artery disease; CESC cis rs6142102 0.517 rs6142046 chr20:32514061 C/T cg08999081 chr20:33150536 PIGU 0.34 5.25 0.31 3.06e-7 Skin pigmentation; CESC cis rs4481887 1.000 rs6697863 chr1:248495588 G/A cg00666640 chr1:248458726 OR2T12 0.41 6.57 0.37 2.64e-10 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16900589 chr2:238617188 LRRFIP1 -0.55 -6.0 -0.35 6.57e-9 Gut microbiome composition (summer); CESC cis rs367943 0.712 rs6594707 chr5:112700503 C/T cg12552261 chr5:112820674 MCC 0.42 5.59 0.32 5.75e-8 Type 2 diabetes; CESC cis rs870825 0.616 rs4386643 chr4:185624281 A/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs875971 0.658 rs432667 chr7:65514633 A/G cg26939375 chr7:64535504 NA 0.48 6.19 0.36 2.32e-9 Aortic root size; CESC cis rs3008870 1.000 rs3008873 chr1:67425770 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg01475377 chr6:109611718 NA 0.5 8.25 0.45 7.57e-15 Reticulocyte fraction of red cells; CESC cis rs7772486 0.875 rs9322048 chr6:146400439 A/G cg05347473 chr6:146136440 FBXO30 0.51 7.03 0.4 1.78e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg24733560 chr20:60626293 TAF4 -0.44 -6.06 -0.35 4.69e-9 Body mass index; CESC cis rs6088590 1.000 rs2076668 chr20:33437621 G/A cg06115741 chr20:33292138 TP53INP2 0.61 7.68 0.43 3.01e-13 Coronary artery disease; CESC cis rs2404602 0.532 rs284892 chr15:76721037 A/G cg00316803 chr15:76480434 C15orf27 -0.35 -5.28 -0.31 2.71e-7 Blood metabolite levels; CESC cis rs78456975 1.000 rs55761535 chr2:1561450 A/G cg26248373 chr2:1572462 NA -0.59 -5.73 -0.33 2.74e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9649465 1.000 rs2299985 chr7:123369044 T/C cg04330084 chr7:123175371 IQUB -0.38 -5.13 -0.3 5.55e-7 Migraine; CESC cis rs13082711 0.911 rs923940 chr3:27459341 C/G cg02860705 chr3:27208620 NA 0.53 6.8 0.39 7.04e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg18180107 chr4:99064573 C4orf37 0.42 5.44 0.32 1.2e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4237845 0.844 rs4630335 chr12:58302258 A/G cg00677455 chr12:58241039 CTDSP2 0.56 7.38 0.41 2.09e-12 Intelligence (multi-trait analysis); CESC cis rs864537 0.618 rs2988277 chr1:167431352 A/G cg09179987 chr1:167433047 CD247 -0.56 -8.49 -0.46 1.49e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs13256369 0.802 rs13281933 chr8:8562665 C/A cg18904891 chr8:8559673 CLDN23 0.69 7.74 0.43 2.13e-13 Obesity-related traits; CESC cis rs1800469 1.000 rs2241712 chr19:41869756 C/T cg09537434 chr19:41945824 ATP5SL -0.67 -8.31 -0.45 5.12e-15 Colorectal cancer; CESC cis rs2072732 0.808 rs67758087 chr1:2937031 A/G cg15211996 chr1:2936768 ACTRT2 0.34 5.6 0.33 5.36e-8 Plateletcrit; CESC cis rs3806843 0.706 rs2563302 chr5:140079051 T/C cg16179182 chr5:140090404 VTRNA1-1 0.39 5.03 0.3 9.22e-7 Depressive symptoms (multi-trait analysis); CESC cis rs8067354 0.789 rs4622571 chr17:57884397 T/A cg13753209 chr17:57696993 CLTC 0.47 6.5 0.37 3.9e-10 Hemoglobin concentration; CESC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg03806693 chr22:41940476 POLR3H 1.13 15.27 0.68 3.52e-38 Vitiligo; CESC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.68 -0.33 3.49e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7918232 0.941 rs4749228 chr10:27433618 C/T cg14442939 chr10:27389572 ANKRD26 -0.72 -6.71 -0.38 1.16e-10 Breast cancer; CESC cis rs2075671 0.903 rs11520986 chr7:100276994 A/G cg20848291 chr7:100343083 ZAN -0.81 -10.52 -0.54 7.29e-22 Other erythrocyte phenotypes; CESC cis rs9911578 1.000 rs9892062 chr17:56976981 G/A cg05425664 chr17:57184151 TRIM37 -0.5 -6.81 -0.39 6.5500000000000006e-11 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.25e-30 Prudent dietary pattern; CESC cis rs4973397 0.601 rs2034412 chr2:232288061 C/G cg09339159 chr2:232260559 B3GNT7 -0.47 -5.62 -0.33 4.91e-8 Anti-saccade response; CESC cis rs2243480 1.000 rs313813 chr7:65503500 C/T cg13147721 chr7:65941812 NA -0.87 -8.22 -0.45 8.94e-15 Diabetic kidney disease; CESC cis rs6499255 0.904 rs60010276 chr16:69674805 C/T cg15192750 chr16:69999425 NA 0.46 5.34 0.31 2.04e-7 IgE levels; CESC cis rs35110281 0.837 rs2838342 chr21:45077865 G/A cg01579765 chr21:45077557 HSF2BP -0.58 -10.02 -0.52 3.09e-20 Mean corpuscular volume; CESC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.45 5.14 0.3 5.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.81 0.34 1.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1707322 1.000 rs10890380 chr1:46449469 A/G cg03146154 chr1:46216737 IPP 0.75 10.29 0.53 4.13e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6424115 0.867 rs2501432 chr1:24201920 T/C cg10978503 chr1:24200527 CNR2 0.33 6.6 0.38 2.2e-10 Immature fraction of reticulocytes; CESC trans rs7716219 0.731 rs7704138 chr5:54944262 C/T cg20755408 chr12:498145 KDM5A;CCDC77 -0.39 -6.0 -0.35 6.44e-9 Height; CESC cis rs12711979 0.765 rs7559461 chr2:3818623 G/A cg17052675 chr2:3827356 NA -0.42 -6.45 -0.37 5.34e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg07308232 chr7:1071921 C7orf50 -0.45 -6.34 -0.36 9.83e-10 Longevity;Endometriosis; CESC cis rs7089973 0.872 rs35622181 chr10:116631976 C/T cg23260525 chr10:116636907 FAM160B1 0.37 6.15 0.35 2.84e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs75477785 1.000 rs2235377 chr1:209975392 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.88 5.74 0.33 2.62e-8 Cleft lip with or without cleft palate; CESC cis rs910316 0.935 rs175422 chr14:75627319 T/A cg11812906 chr14:75593930 NEK9 -0.87 -14.35 -0.66 5.82e-35 Height; CESC cis rs7044106 0.791 rs10985000 chr9:123484115 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.3 0.53 3.82e-21 Hip circumference adjusted for BMI; CESC cis rs478304 0.651 rs10896038 chr11:65505528 G/C cg27068330 chr11:65405492 SIPA1 -0.45 -5.46 -0.32 1.08e-7 Acne (severe); CESC trans rs427691 0.625 rs372062 chr5:109010527 G/A cg00054525 chr16:88717587 CYBA -0.61 -6.8 -0.39 7.05e-11 Autism spectrum disorder or schizophrenia; CESC cis rs2243480 0.901 rs57126451 chr7:65416306 T/C cg13147721 chr7:65941812 NA -0.87 -8.57 -0.47 8.79e-16 Diabetic kidney disease; CESC cis rs2835872 0.758 rs1787394 chr21:39036176 C/A cg06728970 chr21:39037746 KCNJ6 0.3 5.57 0.32 6.2e-8 Electroencephalographic traits in alcoholism; CESC cis rs736408 0.677 rs678 chr3:52820981 A/T cg07507251 chr3:52567010 NT5DC2 0.37 5.98 0.34 7.16e-9 Bipolar disorder; CESC cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg05234568 chr11:5960015 NA -0.52 -5.92 -0.34 9.79e-9 DNA methylation (variation); CESC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg14829155 chr15:31115871 NA -0.76 -10.54 -0.54 6.55e-22 Huntington's disease progression; CESC trans rs35110281 0.591 rs162366 chr21:44935383 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.48 -6.53 -0.37 3.41e-10 Mean corpuscular volume; CESC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg12963246 chr6:28129442 ZNF389 0.5 6.58 0.37 2.51e-10 Parkinson's disease; CESC cis rs636291 0.500 rs655271 chr1:10536635 G/A cg07384165 chr1:10488281 NA -0.58 -8.61 -0.47 6.84e-16 Prostate cancer; CESC cis rs7793919 0.691 rs4077986 chr7:4766676 A/G cg09789173 chr7:4769017 FOXK1 0.63 9.17 0.49 1.34e-17 Mosquito bite size; CESC cis rs2274273 0.905 rs17128183 chr14:55579513 C/T cg04306507 chr14:55594613 LGALS3 -0.31 -6.31 -0.36 1.15e-9 Protein biomarker; CESC cis rs9430161 0.645 rs12081186 chr1:11034195 T/C cg27631724 chr1:11040367 C1orf127 0.38 6.21 0.36 2.02e-9 Ewing sarcoma; CESC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg08027265 chr7:2291960 NA -0.45 -6.99 -0.39 2.21e-11 Bipolar disorder and schizophrenia; CESC cis rs9790314 0.586 rs1839491 chr3:161126429 C/A cg03342759 chr3:160939853 NMD3 -0.45 -5.77 -0.33 2.21e-8 Morning vs. evening chronotype; CESC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.29 0.57 2.21e-24 Alzheimer's disease; CESC cis rs17376456 0.877 rs67066109 chr5:93494101 G/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.04 0.3 8.6e-7 Diabetic retinopathy; CESC cis rs727563 0.594 rs132807 chr22:42071584 T/C cg17376030 chr22:41985996 PMM1 -0.79 -8.55 -0.47 9.65e-16 Crohn's disease;Inflammatory bowel disease; CESC trans rs11039798 0.620 rs10838833 chr11:48238880 C/T cg15704280 chr7:45808275 SEPT13 0.71 6.65 0.38 1.68e-10 Axial length; CESC cis rs561341 0.783 rs512698 chr17:30292507 G/T cg00745463 chr17:30367425 LRRC37B -0.81 -7.36 -0.41 2.38e-12 Hip circumference adjusted for BMI; CESC cis rs9467160 1.000 rs6922631 chr6:24438734 G/A cg20631270 chr6:24437470 GPLD1 0.42 5.18 0.3 4.49e-7 Liver enzyme levels; CESC cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg16489826 chr6:160211363 TCP1;MRPL18 0.65 7.47 0.42 1.17e-12 Age-related macular degeneration (geographic atrophy); CESC cis rs6933660 0.760 rs6904364 chr6:151754273 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.62 8.55 0.46 1.02e-15 Menarche (age at onset); CESC cis rs2228479 0.850 rs11644526 chr16:89898660 C/T cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs9287719 0.967 rs2110776 chr2:10748810 A/G cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg09365446 chr1:150670422 GOLPH3L 0.4 5.7 0.33 3.11e-8 Melanoma; CESC cis rs10857712 0.754 rs2297032 chr10:135234580 C/T cg01444801 chr10:135216882 MTG1 -0.46 -5.24 -0.31 3.29e-7 Systemic lupus erythematosus; CESC cis rs2228479 0.850 rs2302162 chr16:89845287 A/G cg00800038 chr16:89945340 TCF25 -0.92 -7.65 -0.43 3.63e-13 Skin colour saturation; CESC cis rs8077577 0.945 rs62073609 chr17:18071843 T/C cg16794390 chr17:18148240 FLII 0.4 5.26 0.31 3.04e-7 Obesity-related traits; CESC trans rs78049276 0.736 rs73855814 chr4:148397751 G/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.64 -6.73 -0.38 1.02e-10 Pulse pressure; CESC cis rs1375194 0.509 rs62150473 chr2:33822320 G/A cg04131969 chr2:33951647 MYADML -0.53 -6.71 -0.38 1.21e-10 Response to antidepressants in depression; CESC cis rs2282802 0.685 rs11745502 chr5:139558808 G/A cg26211634 chr5:139558579 C5orf32 -0.48 -7.04 -0.4 1.68e-11 Intelligence (multi-trait analysis); CESC cis rs7631605 0.875 rs56180213 chr3:37109633 C/A cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.08 -0.3 7.09e-7 Cerebrospinal P-tau181p levels; CESC cis rs72772090 0.539 rs11135480 chr5:96110582 T/G cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.03 -0.3 8.86e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4835473 0.932 rs35947975 chr4:144700122 G/A cg25736465 chr4:144833511 NA -0.33 -5.23 -0.31 3.48e-7 Immature fraction of reticulocytes; CESC cis rs1707322 0.928 rs10732844 chr1:46372688 T/C cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9910055 0.530 rs11656758 chr17:42301541 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.35 5.14 0.3 5.27e-7 Total body bone mineral density; CESC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg19077165 chr18:44547161 KATNAL2 -0.54 -7.54 -0.42 7.52e-13 Personality dimensions; CESC cis rs6732160 0.845 rs11894833 chr2:73388418 G/T cg01422370 chr2:73384389 NA -0.43 -7.35 -0.41 2.43e-12 Intelligence (multi-trait analysis); CESC cis rs10979 1.000 rs10979 chr6:143890039 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs8038465 0.516 rs8037836 chr15:73859855 G/A cg15420318 chr15:73925796 NPTN 0.55 8.05 0.44 2.75e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9487051 0.735 rs1146246 chr6:109519741 C/T cg01475377 chr6:109611718 NA -0.37 -5.55 -0.32 6.99e-8 Reticulocyte fraction of red cells; CESC cis rs7124681 0.584 rs7950674 chr11:47871017 T/C cg18512352 chr11:47633146 NA 0.35 5.45 0.32 1.17e-7 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg27535305 chr1:53392650 SCP2 -0.34 -5.56 -0.32 6.66e-8 Monocyte count; CESC cis rs6032067 0.777 rs2868237 chr20:43794189 C/T cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs2273669 0.667 rs2273668 chr6:109323519 G/T cg05315195 chr6:109294784 ARMC2 -0.66 -6.01 -0.35 6.04e-9 Prostate cancer; CESC cis rs977987 0.843 rs4887820 chr16:75397287 C/T cg03315344 chr16:75512273 CHST6 0.39 5.63 0.33 4.61e-8 Dupuytren's disease; CESC cis rs1372520 0.684 rs2583979 chr4:90750588 A/T cg15133208 chr4:90757351 SNCA -0.4 -5.37 -0.31 1.71e-7 Neuroticism; CESC trans rs4596713 0.538 rs4592105 chr9:71754305 T/G cg16512924 chr15:28394682 HERC2 0.5 6.27 0.36 1.43e-9 Headache; CESC cis rs10979 0.679 rs9403510 chr6:143892174 C/T cg25407410 chr6:143891975 LOC285740 -0.55 -7.7 -0.43 2.68e-13 Hypospadias; CESC cis rs7592578 0.825 rs12477369 chr2:191455624 G/T cg27211696 chr2:191398769 TMEM194B 0.56 5.1 0.3 6.48e-7 Diastolic blood pressure; CESC cis rs10214930 0.647 rs7791369 chr7:27912080 C/T cg05786569 chr7:27702416 HIBADH 0.44 5.2 0.3 4.05e-7 Hypospadias; CESC cis rs2066819 1.000 rs77853814 chr12:56687572 G/T cg26714650 chr12:56694279 CS -1.44 -9.83 -0.52 1.25e-19 Psoriasis vulgaris; CESC cis rs9611565 0.546 rs739129 chr22:42118249 G/A cg06481639 chr22:41940642 POLR3H 0.59 5.95 0.34 8.35e-9 Vitiligo; CESC cis rs941873 0.805 rs10824747 chr10:81118464 T/C cg08514558 chr10:81106712 PPIF 0.35 5.92 0.34 9.89e-9 Height; CESC cis rs7666738 0.606 rs7663216 chr4:99088385 A/C cg05340658 chr4:99064831 C4orf37 0.64 9.0 0.48 4.38e-17 Colonoscopy-negative controls vs population controls; CESC cis rs447 1.000 rs7783472 chr7:83751882 G/A cg22846510 chr7:83753280 SEMA3A -0.45 -5.67 -0.33 3.8e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2304069 0.779 rs245050 chr5:149346960 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.72 -9.33 -0.5 4.38e-18 HIV-1 control; CESC cis rs6693567 0.545 rs12049177 chr1:150474337 G/A cg09579323 chr1:150459698 TARS2 0.45 5.54 0.32 7.24e-8 Migraine; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg27200190 chr17:35766714 ACACA;TADA2A -0.46 -6.33 -0.36 1.05e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs11614062 0.761 rs11107115 chr12:93972987 A/G cg18151635 chr12:93972918 NA -0.45 -5.92 -0.34 9.99e-9 Height; CESC cis rs7267979 0.816 rs1044573 chr20:25206654 A/G cg08601574 chr20:25228251 PYGB 0.37 5.28 0.31 2.71e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg03760483 chr17:6899297 ALOX12 -0.43 -7.84 -0.43 1.08e-13 Tonsillectomy; CESC cis rs78456975 0.506 rs6756310 chr2:1549809 A/G cg01028140 chr2:1542097 TPO -0.47 -5.93 -0.34 9.62e-9 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs736801 0.729 rs1050152 chr5:131676320 C/T cg21138405 chr5:131827807 IRF1 -0.36 -5.13 -0.3 5.71e-7 Breast cancer;Mosquito bite size; CESC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg25427524 chr10:38739819 LOC399744 -0.71 -10.42 -0.54 1.54e-21 Extrinsic epigenetic age acceleration; CESC cis rs7714584 1.000 rs2004711 chr5:150225068 C/T cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs4660306 0.961 rs4660862 chr1:45955056 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.86e-13 Homocysteine levels; CESC cis rs2074585 0.802 rs2589940 chr15:90931363 C/T cg22089800 chr15:90895588 ZNF774 0.68 9.5 0.5 1.35e-18 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs61931739 0.534 rs35056575 chr12:34142914 A/T cg19457237 chr12:34500585 NA -0.38 -5.16 -0.3 4.82e-7 Morning vs. evening chronotype; CESC cis rs3768617 0.510 rs1413389 chr1:183096668 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs7100689 0.556 rs3120976 chr10:82025682 C/A cg09936400 chr10:82049201 MAT1A 0.35 5.17 0.3 4.62e-7 Post bronchodilator FEV1; CESC cis rs2404602 0.669 rs8036703 chr15:76951040 A/G cg22467129 chr15:76604101 ETFA -0.35 -5.18 -0.3 4.46e-7 Blood metabolite levels; CESC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.52 0.42 8.66e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg11764359 chr7:65958608 NA 0.8 9.75 0.51 2.17e-19 Aortic root size; CESC cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -10.25 -0.53 5.55e-21 Chronic sinus infection; CESC cis rs7828089 0.504 rs12676477 chr8:22266425 T/C cg23129673 chr8:22266227 SLC39A14 0.35 5.17 0.3 4.64e-7 Verbal declarative memory; CESC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg14393609 chr7:65229607 NA 0.52 7.08 0.4 1.33e-11 Aortic root size; CESC trans rs9329221 0.683 rs4598253 chr8:9890304 A/T cg15556689 chr8:8085844 FLJ10661 -0.56 -7.35 -0.41 2.5e-12 Neuroticism; CESC cis rs9911578 0.867 rs4793941 chr17:56472366 G/A cg12560992 chr17:57184187 TRIM37 -0.87 -14.37 -0.66 5.07e-35 Intelligence (multi-trait analysis); CESC cis rs7017914 0.934 rs7814274 chr8:71570411 C/T cg23757474 chr8:71581111 LACTB2;XKR9 0.41 5.22 0.31 3.58e-7 Bone mineral density; CESC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.04 -0.56 1.41e-23 Alzheimer's disease; CESC cis rs7084402 0.935 rs10740732 chr10:60352888 G/A cg07615347 chr10:60278583 BICC1 0.54 8.25 0.45 7.48e-15 Refractive error; CESC cis rs10979 0.597 rs9496684 chr6:143908687 C/A cg25407410 chr6:143891975 LOC285740 -0.49 -6.57 -0.37 2.58e-10 Hypospadias; CESC cis rs1707322 1.000 rs10890381 chr1:46451771 T/G cg05343316 chr1:45956843 TESK2 0.5 6.13 0.35 3.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17253792 0.545 rs12886406 chr14:56027605 G/A cg01858014 chr14:56050164 KTN1 -0.88 -6.42 -0.37 6.21e-10 Putamen volume; CESC cis rs11785400 0.793 rs4567014 chr8:143737690 G/C cg10596483 chr8:143751796 JRK 0.43 5.41 0.32 1.37e-7 Schizophrenia; CESC trans rs11098499 0.954 rs1546505 chr4:120241224 A/G cg25214090 chr10:38739885 LOC399744 0.71 9.9 0.52 7.1e-20 Corneal astigmatism; CESC cis rs9300255 0.596 rs10734900 chr12:123743445 G/A cg00376283 chr12:123451042 ABCB9 0.66 8.97 0.48 5.43e-17 Neutrophil percentage of white cells; CESC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg21724239 chr8:58056113 NA 0.58 6.07 0.35 4.37e-9 Developmental language disorder (linguistic errors); CESC cis rs3008870 1.000 rs2755245 chr1:67487964 C/G cg02640540 chr1:67518911 SLC35D1 0.47 5.14 0.3 5.3e-7 Lymphocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05556477 chr5:131705319 SLC22A5 0.47 6.08 0.35 4.2e-9 Gut microbiota (bacterial taxa); CESC cis rs10129255 1.000 rs10129407 chr14:107176199 G/C cg23076370 chr14:107095027 NA -0.42 -5.03 -0.3 9.05e-7 Kawasaki disease; CESC cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg11987759 chr7:65425863 GUSB 0.38 5.1 0.3 6.48e-7 Aortic root size; CESC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg15445000 chr17:37608096 MED1 0.39 6.38 0.36 7.82e-10 Glomerular filtration rate (creatinine); CESC cis rs10489202 1.000 rs12407660 chr1:167954363 C/T cg24449463 chr1:168025552 DCAF6 -0.46 -5.34 -0.31 2.02e-7 Schizophrenia; CESC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg07936489 chr17:37558343 FBXL20 -0.78 -11.38 -0.57 1.08e-24 Glomerular filtration rate (creatinine); CESC cis rs6424115 0.830 rs1106 chr1:24200772 C/G cg10978503 chr1:24200527 CNR2 0.33 6.62 0.38 1.93e-10 Immature fraction of reticulocytes; CESC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg06601766 chr17:61851465 DDX42;CCDC47 -0.46 -5.61 -0.33 5.06e-8 Prudent dietary pattern; CESC cis rs3796352 0.892 rs9756317 chr3:53088815 T/C cg15956490 chr3:53032818 SFMBT1 -0.58 -5.34 -0.31 2.02e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs748404 0.697 rs564946 chr15:43556272 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.85 0.43 1.01e-13 Lung cancer; CESC trans rs8073060 0.586 rs188959 chr17:34021307 C/A cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs2228479 0.717 rs9282682 chr16:89805794 A/G cg14709524 chr16:89940631 TCF25 0.56 5.06 0.3 7.85e-7 Skin colour saturation; CESC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg04511125 chr2:88470314 THNSL2 0.69 6.76 0.38 8.71e-11 Plasma clusterin levels; CESC cis rs2243480 1.000 rs35542501 chr7:65431215 T/C cg13147721 chr7:65941812 NA -0.86 -8.55 -0.47 9.73e-16 Diabetic kidney disease; CESC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg06456125 chr7:65229604 NA 0.44 5.67 0.33 3.71e-8 Aortic root size; CESC cis rs11252926 0.550 rs10904148 chr10:454551 G/T cg03684893 chr10:554711 DIP2C -0.37 -5.36 -0.31 1.79e-7 Psychosis in Alzheimer's disease; CESC cis rs9430161 0.611 rs12081181 chr1:11034165 T/G cg27631724 chr1:11040367 C1orf127 0.37 5.92 0.34 1.01e-8 Ewing sarcoma; CESC cis rs7665939 1.000 rs72727637 chr4:190106678 G/T cg09826759 chr4:190284978 NA -0.86 -7.15 -0.4 8.52e-12 Amyotrophic lateral sclerosis; CESC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.59 0.38 2.35e-10 Bipolar disorder; CESC trans rs3942852 0.696 rs4597030 chr11:48176573 G/A cg03929089 chr4:120376271 NA -0.66 -7.24 -0.41 4.83e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs1005277 0.638 rs1005278 chr10:38218748 G/A cg00409905 chr10:38381863 ZNF37A 0.4 5.16 0.3 4.78e-7 Extrinsic epigenetic age acceleration; CESC cis rs965469 0.671 rs6139076 chr20:3305210 T/C cg25506879 chr20:3388711 C20orf194 -0.49 -5.36 -0.31 1.79e-7 IFN-related cytopenia; CESC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.61 0.42 4.95e-13 Prudent dietary pattern; CESC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg03388025 chr16:89894329 SPIRE2 -0.38 -7.34 -0.41 2.6e-12 Vitiligo; CESC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg02475777 chr4:1388615 CRIPAK 0.71 8.99 0.48 4.82e-17 Longevity; CESC cis rs9457247 0.765 rs10484531 chr6:167454434 G/A cg07741184 chr6:167504864 NA 0.36 6.56 0.37 2.74e-10 Crohn's disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg01764079 chr8:144718741 ZNF623 -0.46 -6.29 -0.36 1.32e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02073954 chr6:28193080 ZNF193 0.64 7.27 0.41 3.97e-12 Gut microbiome composition (summer); CESC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg22029157 chr1:209979665 IRF6 0.69 10.12 0.53 1.44e-20 Cleft lip with or without cleft palate; CESC trans rs2727020 0.702 rs609054 chr11:49219725 C/G cg15704280 chr7:45808275 SEPT13 0.85 13.98 0.65 1.19e-33 Coronary artery disease; CESC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg11663144 chr21:46675770 NA -0.47 -7.06 -0.4 1.5e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11190604 1.000 rs11190578 chr10:102238953 C/T cg07080220 chr10:102295463 HIF1AN 0.56 5.59 0.32 5.61e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7000551 0.638 rs2469771 chr8:22376627 T/C cg12081754 chr8:22256438 SLC39A14 0.4 5.35 0.31 1.88e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg19622623 chr12:86230825 RASSF9 -0.42 -5.23 -0.31 3.51e-7 Major depressive disorder; CESC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.42 -5.35 -0.31 1.91e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg12963246 chr6:28129442 ZNF389 0.58 7.62 0.42 4.61e-13 Depression; CESC cis rs807669 0.903 rs1018764 chr22:19172006 T/C cg02655711 chr22:19163373 SLC25A1 0.97 15.0 0.68 3.01e-37 Metabolite levels; CESC cis rs10791323 0.569 rs10736608 chr11:133740048 C/T cg15485101 chr11:133734466 NA 0.3 5.18 0.3 4.45e-7 Childhood ear infection; CESC cis rs11098499 0.754 rs11732087 chr4:120239831 A/G cg09307838 chr4:120376055 NA 0.79 10.63 0.55 3.17e-22 Corneal astigmatism; CESC cis rs4563143 0.675 rs55849754 chr19:29279665 G/A cg12667521 chr19:29218732 NA 0.48 6.19 0.36 2.22e-9 Methadone dose in opioid dependence; CESC cis rs7772486 0.875 rs2814863 chr6:146347299 C/T cg23711669 chr6:146136114 FBXO30 -0.79 -11.35 -0.57 1.37e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs2228479 0.850 rs17233455 chr16:89816407 A/G cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs7267979 1.000 rs2482927 chr20:25327151 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -15.72 -0.69 8.65e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs1784581 0.588 rs7451121 chr6:162412344 A/G cg17173639 chr6:162384350 PARK2 0.56 8.43 0.46 2.21e-15 Itch intensity from mosquito bite; CESC cis rs2637266 0.783 rs2588333 chr10:78538952 A/G cg18941641 chr10:78392320 NA 0.39 7.75 0.43 1.99e-13 Pulmonary function; CESC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg22638593 chr5:131593259 PDLIM4 0.39 5.07 0.3 7.56e-7 Acylcarnitine levels; CESC cis rs9487051 0.768 rs463916 chr6:109520538 A/G cg01475377 chr6:109611718 NA -0.45 -6.81 -0.39 6.35e-11 Reticulocyte fraction of red cells; CESC cis rs10129255 0.912 rs8009135 chr14:107185767 A/G cg23076370 chr14:107095027 NA -0.49 -6.26 -0.36 1.56e-9 Kawasaki disease; CESC trans rs2842169 0.558 rs11597150 chr10:128292604 A/G cg10374248 chr10:99083645 NA -0.74 -6.28 -0.36 1.41e-9 Response to radiotherapy in prostate cancer (overall toxicity); CESC cis rs7560272 0.538 rs1806683 chr2:73939812 C/T cg20560298 chr2:73613845 ALMS1 -0.41 -5.62 -0.33 4.81e-8 Schizophrenia; CESC cis rs1691799 0.899 rs1168293 chr12:66733904 G/A cg16791601 chr12:66731901 HELB -0.62 -9.95 -0.52 4.98e-20 White blood cell count (basophil); CESC cis rs7246657 0.765 rs7247259 chr19:37851090 T/C cg23950597 chr19:37808831 NA -0.55 -6.09 -0.35 3.96e-9 Coronary artery calcification; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21348586 chr8:141461100 TRAPPC9 -0.59 -6.92 -0.39 3.37e-11 Gut microbiome composition (summer); CESC cis rs3857536 0.813 rs9354403 chr6:66943426 A/G cg07460842 chr6:66804631 NA -0.41 -5.28 -0.31 2.71e-7 Blood trace element (Cu levels); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06901790 chr16:31712112 C16orf67 -0.51 -6.73 -0.38 1.03e-10 Fibrinogen levels; CESC cis rs2439831 0.867 rs2245715 chr15:43818052 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.72 9.43 0.5 2.23e-18 Lung cancer in ever smokers; CESC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.16 0.45 1.32e-14 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11611950 chr6:24667276 ACOT13;TTRAP 0.53 6.05 0.35 4.89e-9 Gut microbiome composition (summer); CESC cis rs12681366 0.734 rs4735292 chr8:95408731 C/T cg13257157 chr8:95487014 RAD54B 0.37 5.04 0.3 8.46e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs35146811 0.555 rs2527898 chr7:99534030 C/G cg22531904 chr7:99595276 NA -0.4 -5.04 -0.3 8.8e-7 Coronary artery disease; CESC cis rs6762477 0.505 rs17304079 chr3:50085153 A/G cg24308560 chr3:49941425 MST1R -0.55 -6.76 -0.38 8.93e-11 Menarche (age at onset); CESC cis rs13082711 0.911 rs2370995 chr3:27428216 C/T cg02860705 chr3:27208620 NA 0.52 6.49 0.37 4.14e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs9359856 0.636 rs4706345 chr6:90301565 C/T cg13799429 chr6:90582589 CASP8AP2 -0.46 -5.2 -0.3 3.93e-7 Bipolar disorder; CESC cis rs1865721 0.682 rs1561080 chr18:73145847 A/G cg26385618 chr18:73139727 C18orf62 -0.46 -7.43 -0.42 1.48e-12 Intelligence; CESC cis rs34779708 0.733 rs11010146 chr10:35541561 T/A cg03585969 chr10:35415529 CREM 0.56 6.42 0.37 6.15e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs77972916 0.536 rs6751209 chr2:43588302 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -5.17 -0.3 4.57e-7 Granulocyte percentage of myeloid white cells; CESC cis rs10752881 1.000 rs12126434 chr1:182988414 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.86 -13.62 -0.64 2.2e-32 Colorectal cancer; CESC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs11645898 0.810 rs72787060 chr16:72105371 T/C cg14768367 chr16:72042858 DHODH -0.77 -6.17 -0.35 2.48e-9 Blood protein levels; CESC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg11663144 chr21:46675770 NA -0.56 -8.8 -0.48 1.82e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8067545 0.750 rs4925072 chr17:19956899 C/T cg13482628 chr17:19912719 NA -0.38 -5.08 -0.3 7.27e-7 Schizophrenia; CESC cis rs12822507 0.868 rs61915599 chr12:12768409 A/G cg04607235 chr12:12878440 APOLD1 -0.49 -6.11 -0.35 3.56e-9 Systemic lupus erythematosus; CESC cis rs75477785 1.000 rs78355191 chr1:210042077 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.82 5.27 0.31 2.79e-7 Cleft lip with or without cleft palate; CESC cis rs7727544 0.581 rs10075801 chr5:131677642 A/G cg14196790 chr5:131705035 SLC22A5 0.36 5.42 0.32 1.33e-7 Blood metabolite levels; CESC cis rs7635838 0.617 rs2606731 chr3:11291615 A/C cg00170343 chr3:11313890 ATG7 0.62 8.68 0.47 4.01e-16 HDL cholesterol; CESC cis rs11112613 0.713 rs11112592 chr12:105951702 C/T cg03607813 chr12:105948248 NA -0.57 -7.09 -0.4 1.2e-11 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg22823121 chr1:150693482 HORMAD1 -0.41 -6.29 -0.36 1.33e-9 Lymphocyte counts; CESC cis rs7592578 0.771 rs62181034 chr2:191354963 C/A cg10560079 chr2:191398806 TMEM194B -0.63 -5.62 -0.33 4.81e-8 Diastolic blood pressure; CESC cis rs116095464 0.558 rs6874745 chr5:264527 A/G cg22857025 chr5:266934 NA -1.3 -18.55 -0.75 8.05e-50 Breast cancer; CESC cis rs7703051 0.901 rs4604177 chr5:74808880 C/T cg03227963 chr5:74354835 NA 0.3 5.36 0.31 1.85e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs8060686 0.545 rs12597573 chr16:68167521 A/C cg26727032 chr16:67993705 SLC12A4 0.5 5.46 0.32 1.11e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg12463550 chr7:65579703 CRCP -0.54 -6.65 -0.38 1.65e-10 Aortic root size; CESC cis rs7577696 0.626 rs212754 chr2:32421628 A/G cg02381751 chr2:32503542 YIPF4 0.45 5.41 0.32 1.4e-7 Inflammatory biomarkers; CESC cis rs1008375 1.000 rs6449323 chr4:17683916 A/T cg02297831 chr4:17616191 MED28 0.45 5.51 0.32 8.62e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12887734 0.524 rs4900599 chr14:104283444 G/T cg01849466 chr14:104193079 ZFYVE21 -0.44 -5.62 -0.33 4.74e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs367615 0.591 rs4530812 chr5:108858587 A/C cg17395555 chr5:108820864 NA -0.43 -6.93 -0.39 3.29e-11 Colorectal cancer (SNP x SNP interaction); CESC cis rs9902453 0.838 rs9646438 chr17:28209091 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.08 0.44 2.31e-14 Coffee consumption (cups per day); CESC cis rs6496667 0.557 rs2589951 chr15:90958392 T/C cg10434728 chr15:90938212 IQGAP1 0.31 5.5 0.32 9.17e-8 Rheumatoid arthritis; CESC cis rs250677 0.687 rs40522 chr5:148442295 G/A cg18129178 chr5:148520854 ABLIM3 -0.51 -5.87 -0.34 1.33e-8 Breast cancer; CESC cis rs896854 0.517 rs9643353 chr8:95957063 A/G cg16049864 chr8:95962084 TP53INP1 0.54 7.92 0.44 6.44e-14 Type 2 diabetes; CESC trans rs2727020 0.595 rs10769583 chr11:49483193 G/A cg03929089 chr4:120376271 NA -0.85 -13.45 -0.64 8.77e-32 Coronary artery disease; CESC cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg19912559 chr1:40204330 PPIE 0.42 6.48 0.37 4.37e-10 Blood protein levels; CESC cis rs7020830 1.000 rs7020830 chr9:37085184 A/T cg14294708 chr9:37120828 ZCCHC7 1.22 23.54 0.82 6.97e-67 Schizophrenia; CESC cis rs67478160 0.619 rs3742365 chr14:104198251 A/G cg08213375 chr14:104286397 PPP1R13B 0.47 9.08 0.49 2.53e-17 Schizophrenia; CESC cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.06 0.3 7.71e-7 Tonsillectomy; CESC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg15556689 chr8:8085844 FLJ10661 0.52 6.68 0.38 1.43e-10 Mood instability; CESC cis rs1467026 0.719 rs17037220 chr3:12818103 A/G cg24848339 chr3:12840334 CAND2 0.42 6.64 0.38 1.76e-10 P wave duration; CESC cis rs4727027 0.870 rs11524138 chr7:148799125 G/A cg23583168 chr7:148888333 NA -0.78 -12.16 -0.6 2.45e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4919694 1.000 rs76255497 chr10:104651955 T/C cg04362960 chr10:104952993 NT5C2 0.74 6.45 0.37 5.32e-10 Arsenic metabolism; CESC cis rs941873 0.868 rs12780295 chr10:81115438 G/A cg11057378 chr10:81107060 PPIF 0.32 5.24 0.31 3.25e-7 Height; CESC trans rs10841784 0.959 rs34249976 chr12:21469942 T/C cg00566759 chr18:28682345 DSC2 0.48 6.4 0.37 6.85e-10 Childhood ear infection; CESC cis rs68170813 0.559 rs4730223 chr7:106814234 A/T cg02696742 chr7:106810147 HBP1 0.55 5.31 0.31 2.28e-7 Coronary artery disease; CESC cis rs4076764 0.958 rs11580702 chr1:163385523 C/G cg06092702 chr1:163392909 NA -0.4 -5.89 -0.34 1.18e-8 Motion sickness; CESC cis rs12477438 1.000 rs6542873 chr2:99824965 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.37 -0.41 2.12e-12 Chronic sinus infection; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19519331 chr10:91403645 PANK1 -0.44 -6.12 -0.35 3.26e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg18099408 chr3:52552593 STAB1 -0.36 -6.02 -0.35 5.76e-9 Electroencephalogram traits; CESC cis rs17376456 0.569 rs7736892 chr5:93205597 G/A cg21475434 chr5:93447410 FAM172A -0.52 -5.25 -0.31 3.13e-7 Diabetic retinopathy; CESC cis rs2952156 0.920 rs1565920 chr17:37831613 G/A cg20243544 chr17:37824526 PNMT 0.64 8.3 0.45 5.36e-15 Asthma; CESC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg22105103 chr4:187893119 NA 0.51 7.69 0.43 2.88e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs1941023 0.503 rs4939350 chr11:60136243 C/G cg08716584 chr11:60157161 MS4A7 -0.54 -8.74 -0.47 2.67e-16 Congenital heart disease (maternal effect); CESC cis rs36051895 0.659 rs12337134 chr9:5061578 G/A cg02405213 chr9:5042618 JAK2 -0.5 -6.13 -0.35 3.19e-9 Pediatric autoimmune diseases; CESC cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg25427524 chr10:38739819 LOC399744 -0.68 -9.78 -0.51 1.74e-19 Extrinsic epigenetic age acceleration; CESC cis rs9325144 0.581 rs2653758 chr12:38946233 G/T cg13010199 chr12:38710504 ALG10B -0.39 -5.18 -0.3 4.47e-7 Morning vs. evening chronotype; CESC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg08888203 chr3:10149979 C3orf24 0.55 7.2 0.4 6.16e-12 Alzheimer's disease; CESC cis rs2573652 1.000 rs11634977 chr15:100516472 G/A cg09918751 chr15:100517450 ADAMTS17 -0.4 -7.73 -0.43 2.29e-13 Height; CESC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -7.25 -0.41 4.44e-12 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19901191 chr1:33005091 ZBTB8A 0.58 6.45 0.37 5.22e-10 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10316662 chr8:93156389 NA -0.48 -6.49 -0.37 4.31e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9796 0.870 rs7169375 chr15:41311046 A/G cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.79 -0.38 7.49e-11 Menopause (age at onset); CESC cis rs3126085 1.000 rs3126085 chr1:152300817 G/A cg03465714 chr1:152285911 FLG 0.43 5.22 0.31 3.62e-7 Atopic dermatitis; CESC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg08470875 chr2:26401718 FAM59B -0.47 -5.22 -0.31 3.55e-7 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs73267858 chr17:29059737 A/G cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1050631 0.592 rs1789548 chr18:33724296 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.53 7.16 0.4 7.87e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs765787 0.530 rs55920042 chr15:45541577 G/A cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs7208859 0.623 rs7208441 chr17:29143863 C/T cg13385521 chr17:29058706 SUZ12P 0.82 6.57 0.37 2.6200000000000003e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05290695 chr8:119634602 SAMD12 0.4 6.34 0.36 9.65e-10 Gambling; CESC cis rs7923609 1.000 rs12355784 chr10:65121565 G/T cg01631684 chr10:65280961 REEP3 -0.42 -5.29 -0.31 2.59e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs79349575 0.681 rs56080003 chr17:47019049 A/T cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23333220 chr15:64679825 TRIP4 -0.56 -7.46 -0.42 1.2e-12 Height; CESC cis rs11690935 0.959 rs11904009 chr2:172627343 T/G cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.95 -0.68 4.66e-37 Schizophrenia; CESC cis rs460214 0.528 rs4817954 chr21:40023857 C/T cg05519781 chr21:40033154 ERG -0.45 -5.58 -0.32 6.08e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg19592336 chr6:28129416 ZNF389 0.47 6.44 0.37 5.49e-10 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03885022 chr7:92158293 C7orf64;PEX1 -0.6 -7.06 -0.4 1.49e-11 Gut microbiome composition (summer); CESC cis rs2243480 0.901 rs58207111 chr7:65486723 C/T cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs3820068 0.581 rs16851851 chr1:15929628 C/G cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs9911578 1.000 rs9898626 chr17:56698219 C/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23204345 chr6:108882184 FOXO3 0.6 6.87 0.39 4.5e-11 Gut microbiome composition (summer); CESC cis rs2486288 0.656 rs11631021 chr15:45556829 A/G cg21132104 chr15:45694354 SPATA5L1 -0.63 -7.54 -0.42 7.58e-13 Glomerular filtration rate; CESC cis rs2011503 1.000 rs58074958 chr19:19570555 G/C cg11584989 chr19:19387371 SF4 0.62 7.22 0.41 5.54e-12 Bipolar disorder; CESC cis rs2070488 0.965 rs1984312 chr3:38538466 G/T cg24069376 chr3:38537580 EXOG -0.43 -7.87 -0.44 9.09e-14 Electrocardiographic conduction measures; CESC trans rs7726839 0.540 rs72703079 chr5:595173 T/C cg25482853 chr8:67687455 SGK3 1.04 10.11 0.53 1.55e-20 Obesity-related traits; CESC cis rs9583531 0.689 rs6492308 chr13:111377829 T/C cg15841412 chr13:111365552 ING1 0.45 5.6 0.33 5.46e-8 Coronary artery disease; CESC cis rs11098499 0.754 rs11724409 chr4:120252361 A/G cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05135541 chr1:150039387 VPS45 0.62 7.48 0.42 1.07e-12 Gut microbiome composition (summer); CESC cis rs72901758 0.768 rs11650317 chr17:76251306 A/T cg23302638 chr17:76210176 BIRC5 0.47 5.06 0.3 7.71e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs2463822 1.000 rs2463825 chr11:62094493 G/A cg06239285 chr11:62104954 ASRGL1 0.89 8.97 0.48 5.69e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs1801251 1.000 rs1947105 chr2:233721455 A/G cg08000102 chr2:233561755 GIGYF2 0.71 10.38 0.54 2.12e-21 Coronary artery disease; CESC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg02807482 chr3:125708958 NA -0.39 -5.11 -0.3 6.29e-7 Blood pressure (smoking interaction); CESC cis rs11078597 0.731 rs12937244 chr17:1646317 T/C cg18436246 chr17:1640651 WDR81 0.62 7.59 0.42 5.36e-13 Serum albumin level; CESC cis rs3762637 1.000 rs9836309 chr3:122135195 G/A cg24169773 chr3:122142474 KPNA1 -0.51 -6.03 -0.35 5.56e-9 LDL cholesterol levels; CESC cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12759997 chr1:54518742 TMEM59;C1orf83 0.68 7.86 0.43 9.88e-14 Gut microbiome composition (summer); CESC cis rs7085104 0.700 rs743572 chr10:104597152 A/G cg15744005 chr10:104629667 AS3MT -0.34 -5.32 -0.31 2.17e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs16973500 0.808 rs72801786 chr16:71955085 C/T cg09427745 chr16:71932006 KIAA0174 -0.52 -5.3 -0.31 2.39e-7 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs36051895 0.659 rs1159782 chr9:5078117 T/C cg02405213 chr9:5042618 JAK2 -0.51 -6.18 -0.35 2.45e-9 Pediatric autoimmune diseases; CESC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.82 0.48 1.53e-16 Bipolar disorder; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg09686635 chr1:210001418 C1orf107 -0.48 -6.45 -0.37 5.28e-10 Thyroid stimulating hormone; CESC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg12373951 chr3:133503437 NA -0.36 -5.36 -0.31 1.79e-7 Iron status biomarkers; CESC cis rs938554 0.570 rs7696983 chr4:9995829 A/C cg00071950 chr4:10020882 SLC2A9 0.67 7.76 0.43 1.81e-13 Blood metabolite levels; CESC cis rs854765 0.603 rs4506967 chr17:17990474 A/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.56 0.47 9.59e-16 Total body bone mineral density; CESC cis rs9300255 0.568 rs1627724 chr12:123638580 T/A cg05973401 chr12:123451056 ABCB9 0.5 5.79 0.34 1.98e-8 Neutrophil percentage of white cells; CESC cis rs6543140 0.855 rs4851591 chr2:103077423 T/C cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04838709 chr14:21151782 ANG;RNASE4 0.47 6.65 0.38 1.68e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs870825 0.860 rs60022249 chr4:185600772 T/C cg04058563 chr4:185651563 MLF1IP 0.52 5.13 0.3 5.69e-7 Blood protein levels; CESC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg27170947 chr2:26402098 FAM59B -0.87 -9.81 -0.52 1.41e-19 Gut microbiome composition (summer); CESC cis rs9611565 0.729 rs202654 chr22:41841034 G/A cg06481639 chr22:41940642 POLR3H 0.42 5.03 0.3 9e-7 Vitiligo; CESC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.13 -0.35 3.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs847577 0.646 rs10270222 chr7:97781799 C/T cg21770322 chr7:97807741 LMTK2 -0.5 -7.34 -0.41 2.65e-12 Breast cancer; CESC cis rs7078219 0.714 rs10883363 chr10:101287580 C/T cg09788492 chr10:101292477 NKX2-3 0.31 5.03 0.3 8.88e-7 Dental caries; CESC cis rs11155671 0.530 rs2342767 chr6:150209717 C/G cg09699651 chr6:150184138 LRP11 0.54 7.56 0.42 6.82e-13 Testicular germ cell tumor; CESC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4423214 1.000 rs7944926 chr11:71165625 A/G cg05163923 chr11:71159392 DHCR7 0.76 10.16 0.53 1.05e-20 Vitamin D levels; CESC cis rs3767633 0.502 rs2499845 chr1:161933066 G/C cg09175582 chr1:161736000 ATF6 0.48 5.17 0.3 4.72e-7 IgG glycosylation; CESC cis rs8071756 1.000 rs8076644 chr17:1574548 T/C ch.17.72133F chr17:1577994 PRPF8 0.49 5.31 0.31 2.36e-7 Blood protein levels; CESC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg23161317 chr6:28129485 ZNF389 0.38 5.33 0.31 2.07e-7 Parkinson's disease; CESC trans rs7246657 0.943 rs1035479 chr19:37893300 G/T cg24637308 chr11:6592297 DNHD1 -0.55 -6.32 -0.36 1.1e-9 Coronary artery calcification; CESC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg12463550 chr7:65579703 CRCP -0.56 -7.23 -0.41 5.19e-12 Aortic root size; CESC cis rs523522 0.892 rs4767916 chr12:121024032 T/C cg12219531 chr12:120966889 COQ5 0.76 10.1 0.53 1.68e-20 High light scatter reticulocyte count; CESC cis rs12477438 0.520 rs4340581 chr2:99725025 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.18 0.68 6.85e-38 Chronic sinus infection; CESC cis rs8072100 0.713 rs2136750 chr17:45456100 A/G cg08085267 chr17:45401833 C17orf57 -0.52 -6.54 -0.37 3.11e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2651899 0.865 rs2817126 chr1:3083246 T/G cg22674798 chr1:3096360 PRDM16 0.34 6.57 0.37 2.72e-10 Migraine; CESC cis rs7809799 1.000 rs2395048 chr7:98765552 T/C cg05967295 chr7:98741636 SMURF1 -0.77 -5.41 -0.32 1.37e-7 Ulcerative colitis; CESC cis rs9611565 0.921 rs761366 chr22:41744022 C/G cg17376030 chr22:41985996 PMM1 0.56 5.85 0.34 1.42e-8 Vitiligo; CESC cis rs9611519 0.780 rs9611546 chr22:41698542 C/G cg06634786 chr22:41940651 POLR3H -0.5 -5.36 -0.31 1.83e-7 Neuroticism; CESC cis rs1144333 0.850 rs1251274 chr1:76288587 T/C cg10523679 chr1:76189770 ACADM -0.56 -5.28 -0.31 2.65e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs9457247 1.000 rs421214 chr6:167396629 A/G cg23791538 chr6:167370224 RNASET2 -0.6 -8.48 -0.46 1.57e-15 Crohn's disease; CESC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.83 0.34 1.59e-8 Bipolar disorder; CESC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg07701084 chr6:150067640 NUP43 0.44 6.06 0.35 4.63e-9 Lung cancer; CESC trans rs748404 0.676 rs4401024 chr15:43650335 C/T cg24053811 chr14:70265306 SLC10A1 0.43 6.01 0.35 6.15e-9 Lung cancer; CESC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg02038168 chr22:39784481 NA -0.63 -8.12 -0.45 1.71e-14 Intelligence (multi-trait analysis); CESC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg23161317 chr6:28129485 ZNF389 0.49 6.17 0.35 2.49e-9 Parkinson's disease; CESC cis rs9811920 0.609 rs704583 chr3:99643693 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg05368731 chr17:41323189 NBR1 0.79 10.92 0.56 3.52e-23 Menopause (age at onset); CESC cis rs9549367 0.713 rs2480949 chr13:113853149 T/C cg18105134 chr13:113819100 PROZ 0.55 7.17 0.4 7.52e-12 Platelet distribution width; CESC cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.84 11.38 0.57 1.04e-24 Multiple sclerosis; CESC cis rs6831352 1.000 rs1126673 chr4:100045616 C/T cg12011299 chr4:100065546 ADH4 0.7 8.55 0.47 9.67e-16 Alcohol dependence; CESC cis rs2070488 0.699 rs13078966 chr3:38517914 T/G cg24069376 chr3:38537580 EXOG 0.36 6.09 0.35 4.04e-9 Electrocardiographic conduction measures; CESC cis rs11696501 0.739 rs6073821 chr20:44251791 A/G cg11783356 chr20:44313418 WFDC10B -0.35 -5.42 -0.32 1.35e-7 Brain structure; CESC cis rs6541297 0.703 rs611701 chr1:230324173 C/T cg20703242 chr1:230279135 GALNT2 -0.4 -5.26 -0.31 2.96e-7 Coronary artery disease; CESC cis rs11098499 0.865 rs11098513 chr4:120316075 A/G cg09307838 chr4:120376055 NA 0.92 12.35 0.6 5.56e-28 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24451422 chr1:23751210 TCEA3 0.59 6.43 0.37 5.95e-10 Gut microbiome composition (summer); CESC cis rs2227631 1.000 rs2227631 chr7:100769538 A/G cg08053846 chr7:100769605 SERPINE1 -0.42 -5.9 -0.34 1.11e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17533847 chr17:77812622 CBX4 0.48 6.23 0.36 1.83e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2180341 0.842 rs9372860 chr6:127546605 G/A cg24812749 chr6:127587940 RNF146 0.9 10.7 0.55 1.95e-22 Breast cancer; CESC cis rs1728785 0.901 rs1728797 chr16:68570989 A/T cg02972257 chr16:68554789 NA -0.55 -6.34 -0.36 9.7e-10 Ulcerative colitis; CESC cis rs6430585 0.527 rs1446586 chr2:136407445 C/T cg07169764 chr2:136633963 MCM6 -1.03 -12.54 -0.61 1.21e-28 Corneal structure; CESC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg08392591 chr16:89556376 ANKRD11 0.55 7.5 0.42 9.86e-13 Multiple myeloma (IgH translocation); CESC cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg24110177 chr3:50126178 RBM5 0.53 7.55 0.42 7.24e-13 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17817474 chr15:90809403 NGRN -0.43 -6.31 -0.36 1.17e-9 Gambling; CESC cis rs854765 0.964 rs2230316 chr17:17997209 C/T cg04398451 chr17:18023971 MYO15A 0.68 9.06 0.49 2.91e-17 Total body bone mineral density; CESC cis rs3747547 0.818 rs16934640 chr9:37943164 C/T cg13774184 chr9:37916125 SHB -0.54 -5.58 -0.32 5.79e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs9309473 0.519 rs12991161 chr2:73871371 G/A cg20560298 chr2:73613845 ALMS1 0.51 7.13 0.4 9.62e-12 Metabolite levels; CESC cis rs2730245 0.618 rs859781 chr7:158661758 G/A cg14689365 chr7:158441557 NCAPG2 0.42 5.18 0.3 4.35e-7 Height; CESC cis rs1707322 1.000 rs1707338 chr1:46511981 T/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.65 -0.33 4.08e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg04775059 chr7:64541387 NA -0.41 -5.08 -0.3 7.07e-7 Calcium levels; CESC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg22638593 chr5:131593259 PDLIM4 0.39 5.06 0.3 7.78e-7 Breast cancer; CESC cis rs7845219 0.544 rs4735331 chr8:95917958 C/T cg23172400 chr8:95962367 TP53INP1 -0.38 -7.08 -0.4 1.3e-11 Type 2 diabetes; CESC cis rs6121246 0.567 rs6060344 chr20:30207316 A/G cg13852791 chr20:30311386 BCL2L1 0.57 5.29 0.31 2.54e-7 Mean corpuscular hemoglobin; CESC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg05368731 chr17:41323189 NBR1 0.79 11.1 0.56 9.39e-24 Menopause (age at onset); CESC cis rs7714584 1.000 rs10041072 chr5:150259642 A/G cg22134413 chr5:150180641 NA 0.49 5.38 0.31 1.68e-7 Crohn's disease; CESC cis rs7635838 0.892 rs9823197 chr3:11503133 A/T cg00170343 chr3:11313890 ATG7 0.42 5.67 0.33 3.64e-8 HDL cholesterol; CESC cis rs2637266 1.000 rs7101318 chr10:78379780 T/C cg18941641 chr10:78392320 NA 0.43 8.11 0.45 1.86e-14 Pulmonary function; CESC cis rs941873 0.805 rs10824747 chr10:81118464 T/C cg11057378 chr10:81107060 PPIF 0.36 5.7 0.33 3.22e-8 Height; CESC cis rs9329289 0.851 rs61835719 chr10:2543390 A/G cg18171855 chr10:2543474 NA 0.35 5.26 0.31 2.9e-7 Age-related hearing impairment; CESC trans rs17764205 0.777 rs112570652 chr19:3255789 G/A cg03776506 chr16:30581384 ZNF688 -0.78 -6.03 -0.35 5.44e-9 Bipolar disorder and schizophrenia; CESC cis rs10744422 1.000 rs7972447 chr12:123354545 C/G cg25930673 chr12:123319894 HIP1R -0.65 -5.1 -0.3 6.44e-7 Schizophrenia; CESC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg05564831 chr3:52568323 NT5DC2 0.46 6.93 0.39 3.15e-11 Bipolar disorder; CESC cis rs35146811 0.844 rs13223792 chr7:99675659 T/G cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.45 5.89 0.34 1.16e-8 Coronary artery disease; CESC cis rs4722166 0.630 rs7781534 chr7:22778592 A/C cg05472934 chr7:22766657 IL6 0.87 10.94 0.56 3.06e-23 Lung cancer; CESC cis rs561341 1.000 rs7216102 chr17:30259450 A/G cg12193833 chr17:30244370 NA -0.47 -5.41 -0.32 1.38e-7 Hip circumference adjusted for BMI; CESC cis rs7762018 0.607 rs6907814 chr6:170058206 G/A cg19338460 chr6:170058176 WDR27 -0.84 -7.07 -0.4 1.39e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs74181299 0.892 rs2249105 chr2:65287896 C/T cg05010058 chr2:65284262 CEP68 -0.33 -5.82 -0.34 1.68e-8 Pulse pressure; CESC cis rs6582630 0.519 rs1607882 chr12:38361657 G/A cg13010199 chr12:38710504 ALG10B 0.43 5.48 0.32 9.9e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs3942852 0.910 rs10742831 chr11:48119691 G/A cg15704280 chr7:45808275 SEPT13 -0.62 -6.74 -0.38 1e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs6690583 0.623 rs11588160 chr1:85444226 T/G cg22153463 chr1:85462885 MCOLN2 0.75 7.17 0.4 7.47e-12 Serum sulfate level; CESC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg20243544 chr17:37824526 PNMT -0.47 -5.94 -0.34 9.04e-9 Glomerular filtration rate (creatinine); CESC cis rs7100689 0.784 rs10736341 chr10:82061206 C/G cg09936400 chr10:82049201 MAT1A 0.37 5.3 0.31 2.41e-7 Post bronchodilator FEV1; CESC cis rs9457247 1.000 rs408918 chr6:167399282 G/T cg25258033 chr6:167368657 RNASET2 0.4 6.04 0.35 5.12e-9 Crohn's disease; CESC cis rs992157 0.798 rs7587220 chr2:219160864 C/A cg00012203 chr2:219082015 ARPC2 -0.74 -9.46 -0.5 1.7e-18 Colorectal cancer; CESC cis rs9318086 0.648 rs9507184 chr13:24473642 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.44 6.27 0.36 1.44e-9 Myopia (pathological); CESC cis rs9341808 0.718 rs9294171 chr6:80839815 C/T cg08355045 chr6:80787529 NA 0.34 5.41 0.32 1.41e-7 Sitting height ratio; CESC cis rs7264396 0.635 rs6060688 chr20:34516731 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.75 10.38 0.54 2.12e-21 Total cholesterol levels; CESC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs4237845 0.816 rs61935769 chr12:58294344 G/A cg02175503 chr12:58329896 NA 0.64 7.73 0.43 2.3e-13 Intelligence (multi-trait analysis); CESC trans rs7618501 0.633 rs2856234 chr3:50139142 A/G cg21659725 chr3:3221576 CRBN -0.49 -6.75 -0.38 9.22e-11 Intelligence (multi-trait analysis); CESC cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg26818010 chr10:134567672 INPP5A -0.86 -10.64 -0.55 3.04e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs12325245 0.536 rs71375919 chr16:58547522 C/T cg05725404 chr16:58534157 NDRG4 -0.63 -5.44 -0.32 1.22e-7 Schizophrenia; CESC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg18876405 chr7:65276391 NA 0.72 10.04 0.52 2.67e-20 Calcium levels; CESC cis rs9388451 1.000 rs9388451 chr6:126090377 A/G cg05901451 chr6:126070800 HEY2 -0.64 -9.12 -0.49 1.9e-17 Brugada syndrome; CESC trans rs1493916 1.000 rs12457802 chr18:31389865 A/G cg27147174 chr7:100797783 AP1S1 0.5 6.83 0.39 5.71e-11 Life satisfaction; CESC cis rs6460942 0.597 rs12699381 chr7:12527026 G/A cg06484146 chr7:12443880 VWDE -0.71 -7.7 -0.43 2.7e-13 Coronary artery disease; CESC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg22800045 chr5:56110881 MAP3K1 0.84 10.23 0.53 6.66e-21 Initial pursuit acceleration; CESC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.7 0.43 2.77e-13 Prudent dietary pattern; CESC cis rs7267979 1.000 rs404394 chr20:25447896 A/G cg08601574 chr20:25228251 PYGB 0.37 5.31 0.31 2.31e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7582720 1.000 rs72936842 chr2:203773686 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs9443645 0.901 rs9352667 chr6:79572296 A/G cg05283184 chr6:79620031 NA 0.44 6.82 0.39 6.32e-11 Intelligence (multi-trait analysis); CESC cis rs9814567 1.000 rs9985356 chr3:134232920 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.42 6.17 0.35 2.56e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9318086 0.600 rs9507185 chr13:24473734 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.44 6.28 0.36 1.35e-9 Myopia (pathological); CESC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.715 rs11525003 chr12:38332359 G/A cg13010199 chr12:38710504 ALG10B 0.48 6.11 0.35 3.53e-9 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20117626 chr22:32150034 DEPDC5 0.59 7.27 0.41 4.17e-12 Gut microbiome composition (summer); CESC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg16405210 chr4:1374714 KIAA1530 -0.42 -5.69 -0.33 3.39e-8 Obesity-related traits; CESC cis rs17253792 0.822 rs78615025 chr14:56168012 G/A cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs7666738 0.519 rs11732209 chr4:98801643 A/G cg17366294 chr4:99064904 C4orf37 0.49 6.09 0.35 3.92e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 0.646 rs239934 chr6:167412048 G/A cg07741184 chr6:167504864 NA 0.29 5.26 0.31 2.98e-7 Crohn's disease; CESC cis rs826838 0.967 rs11168299 chr12:38902028 G/T cg26384229 chr12:38710491 ALG10B 0.82 14.52 0.67 1.49e-35 Heart rate; CESC cis rs2303759 0.676 rs7248378 chr19:49908144 C/A cg22590775 chr19:49891494 CCDC155 0.52 6.11 0.35 3.47e-9 Multiple sclerosis; CESC cis rs1707322 0.928 rs6681068 chr1:46398382 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24189559 chr3:12851674 CAND2 0.59 7.24 0.41 4.79e-12 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.79 8.26 0.45 6.82e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6942756 0.806 rs2694572 chr7:128911721 A/G cg02491457 chr7:128862824 NA 0.65 9.51 0.5 1.23e-18 White matter hyperintensity burden; CESC cis rs8020095 0.571 rs9323483 chr14:67239607 C/T cg19548862 chr14:67692701 FAM71D -0.5 -6.2 -0.36 2.13e-9 Depression (quantitative trait); CESC cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg06108461 chr20:60628389 TAF4 -0.63 -8.37 -0.46 3.37e-15 Body mass index; CESC cis rs7847628 0.587 rs1060817 chr9:123583192 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.82 13.32 0.63 2.43e-31 Birth weight; CESC cis rs2425143 0.558 rs7274724 chr20:34539466 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.59 0.32 5.74e-8 Blood protein levels; CESC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg04553112 chr3:125709451 NA -0.55 -6.36 -0.36 8.75e-10 Blood pressure (smoking interaction); CESC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg22963979 chr7:1858916 MAD1L1 -0.38 -5.15 -0.3 5e-7 Bipolar disorder and schizophrenia; CESC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg05368731 chr17:41323189 NBR1 0.78 11.14 0.56 6.78e-24 Menopause (age at onset); CESC cis rs9911578 1.000 rs9892795 chr17:57023054 G/C cg12560992 chr17:57184187 TRIM37 0.92 15.18 0.68 7.1e-38 Intelligence (multi-trait analysis); CESC cis rs16866061 1.000 rs10498163 chr2:225434445 A/G cg12698349 chr2:225449008 CUL3 0.75 11.51 0.58 4.07e-25 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 6.5 0.37 4.07e-10 LDL cholesterol;Cholesterol, total; CESC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg16049864 chr8:95962084 TP53INP1 -0.68 -12.14 -0.6 2.91e-27 Type 2 diabetes; CESC cis rs1256061 0.624 rs1152582 chr14:64692630 G/C cg21174375 chr14:64681225 SYNE2 0.49 6.48 0.37 4.42e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs317689 0.819 rs317685 chr12:69715457 A/G cg14784868 chr12:69753453 YEATS4 -0.48 -5.2 -0.3 3.92e-7 Response to diuretic therapy; CESC cis rs7385804 0.796 rs221801 chr7:100290031 C/A cg20848291 chr7:100343083 ZAN 0.55 7.38 0.41 2.05e-12 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs9457247 0.663 rs1894603 chr6:167434686 C/T cg07741184 chr6:167504864 NA -0.33 -5.81 -0.34 1.83e-8 Crohn's disease; CESC cis rs4950322 0.570 rs72691033 chr1:146732921 C/T cg16700924 chr1:146552102 NA -0.41 -5.12 -0.3 5.98e-7 Protein quantitative trait loci; CESC cis rs2447097 0.935 rs2447094 chr17:2294048 A/C cg04477101 chr17:2275030 SGSM2 0.34 5.03 0.3 8.91e-7 Autism spectrum disorder; CESC cis rs11252926 0.562 rs11252792 chr10:544369 G/A cg03684893 chr10:554711 DIP2C 0.37 5.57 0.32 6.32e-8 Psychosis in Alzheimer's disease; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg09041756 chr7:5570314 ACTB 0.46 6.01 0.35 6.12e-9 Bronchopulmonary dysplasia; CESC cis rs8062405 0.824 rs7191618 chr16:28565667 C/G cg07382826 chr16:28625726 SULT1A1 0.31 5.05 0.3 8.11e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs28489187 0.683 rs1498373 chr1:85790633 G/A cg16011679 chr1:85725395 C1orf52 0.54 6.29 0.36 1.31e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs1945213 0.625 rs7128190 chr11:55858550 A/T cg03929089 chr4:120376271 NA 0.77 7.35 0.41 2.48e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs2658782 0.826 rs1975820 chr11:93081815 G/A cg15737290 chr11:93063684 CCDC67 0.6 7.57 0.42 6.32e-13 Pulmonary function decline; CESC cis rs7662987 0.540 rs2851278 chr4:100021253 G/C cg13256891 chr4:100009986 ADH5 0.75 8.06 0.44 2.6e-14 Smoking initiation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08585351 chr13:22178326 EFHA1 0.57 6.78 0.38 7.59e-11 Gut microbiome composition (summer); CESC cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.18 0.35 2.43e-9 Colorectal cancer; CESC cis rs2637266 0.579 rs10824424 chr10:78321443 A/G cg18941641 chr10:78392320 NA 0.33 5.11 0.3 6.22e-7 Pulmonary function; CESC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Depression; CESC cis rs8141529 0.702 rs469992 chr22:29314899 T/C cg15103426 chr22:29168792 CCDC117 -0.61 -7.81 -0.43 1.33e-13 Lymphocyte counts; CESC trans rs1545843 0.623 rs4326842 chr12:84797890 C/A cg03015433 chr16:56623111 MT3 -0.34 -6.14 -0.35 3.04e-9 Major depressive disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16328610 chr6:83777335 DOPEY1 -0.5 -6.13 -0.35 3.14e-9 Ulcerative colitis; CESC cis rs477692 0.905 rs570967 chr10:131421330 T/G cg05714579 chr10:131428358 MGMT 0.55 7.89 0.44 7.86e-14 Response to temozolomide; CESC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg05132306 chr1:1846340 CALML6 -0.3 -6.24 -0.36 1.77e-9 Body mass index; CESC cis rs9649465 1.000 rs11765478 chr7:123362872 A/C cg04330084 chr7:123175371 IQUB -0.38 -5.13 -0.3 5.55e-7 Migraine; CESC cis rs888194 0.714 rs7308864 chr12:109871179 A/G cg19025524 chr12:109796872 NA -0.35 -5.21 -0.3 3.84e-7 Neuroticism; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg27071285 chr11:62559100 TMEM223 -0.5 -6.24 -0.36 1.74e-9 Asthma; CESC cis rs807669 0.903 rs762527 chr22:19183470 A/G cg02655711 chr22:19163373 SLC25A1 0.97 15.0 0.68 2.98e-37 Metabolite levels; CESC cis rs8067545 1.000 rs4925066 chr17:19915292 A/G cg13482628 chr17:19912719 NA 0.43 5.81 0.34 1.78e-8 Schizophrenia; CESC cis rs1401999 0.628 rs6798870 chr3:183740350 G/A cg01324343 chr3:183735012 ABCC5 0.54 10.75 0.55 1.28e-22 Anterior chamber depth; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18796520 chr12:4758272 NDUFA9 0.48 6.02 0.35 5.73e-9 Gut microbiota (bacterial taxa); CESC cis rs933688 1.000 rs6865495 chr5:90746424 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 12.03 0.59 6.82e-27 Smoking behavior; CESC cis rs7188697 0.922 rs7186997 chr16:58603348 A/G cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC cis rs7188697 0.885 rs246194 chr16:58573901 G/A cg21335942 chr16:58549945 SETD6 0.46 5.36 0.31 1.84e-7 QT interval; CESC cis rs75804782 0.641 rs72983853 chr2:239324210 C/T cg18131467 chr2:239335373 ASB1 -0.69 -5.73 -0.33 2.75e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs9911578 0.874 rs302865 chr17:56756977 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.2 -0.4 6.21e-12 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23709988 chr14:23772096 PPP1R3E -0.46 -6.44 -0.37 5.58e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs950776 0.616 rs647041 chr15:78880481 T/C cg24631222 chr15:78858424 CHRNA5 0.46 5.74 0.33 2.65e-8 Sudden cardiac arrest; CESC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg18230493 chr5:56204884 C5orf35 -0.67 -8.08 -0.44 2.36e-14 Initial pursuit acceleration; CESC cis rs12142240 0.698 rs1475389 chr1:46816429 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC trans rs9833726 0.799 rs13325775 chr3:86137307 C/G cg10416071 chr15:75628863 COMMD4 0.59 6.12 0.35 3.37e-9 Breast cancer; CESC cis rs9611565 0.569 rs6002328 chr22:41710034 T/C cg06481639 chr22:41940642 POLR3H -0.47 -5.41 -0.32 1.37e-7 Vitiligo; CESC cis rs1008375 0.932 rs4698626 chr4:17605821 G/C cg02297831 chr4:17616191 MED28 0.52 6.61 0.38 2.1e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs832540 0.931 rs2662040 chr5:56246610 A/G cg14703610 chr5:56206110 C5orf35 -0.52 -6.88 -0.39 4.41e-11 Coronary artery disease; CESC cis rs8067545 0.532 rs35915823 chr17:19973397 A/G cg12073167 chr17:19770448 ULK2 -0.43 -5.21 -0.3 3.88e-7 Schizophrenia; CESC cis rs9611565 0.918 rs9611561 chr22:41757234 C/G cg06634786 chr22:41940651 POLR3H -0.66 -6.76 -0.38 8.78e-11 Vitiligo; CESC cis rs672059 0.513 rs572977 chr1:183164991 C/G cg01949993 chr1:183155116 LAMC2 -0.29 -5.26 -0.31 2.91e-7 Hypertriglyceridemia; CESC cis rs2991971 0.747 rs2492841 chr1:45894891 G/T cg05343316 chr1:45956843 TESK2 0.61 8.6 0.47 6.97e-16 High light scatter reticulocyte count; CESC cis rs2439831 0.681 rs825739 chr15:43592428 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.89 13.39 0.64 1.43e-31 Lung cancer in ever smokers; CESC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs847577 0.630 rs2132276 chr7:97826340 G/A cg24562669 chr7:97807699 LMTK2 0.83 13.83 0.65 4.09e-33 Breast cancer; CESC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg19592336 chr6:28129416 ZNF389 0.54 6.94 0.39 3e-11 Parkinson's disease; CESC cis rs72634258 0.503 rs34177663 chr1:7833228 A/G cg26816564 chr1:7831052 VAMP3 0.69 6.39 0.37 7.6e-10 Inflammatory bowel disease; CESC cis rs11098499 0.863 rs1552092 chr4:120488496 C/T cg09307838 chr4:120376055 NA 0.91 12.68 0.61 4e-29 Corneal astigmatism; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg01008097 chr4:110267632 NA -0.34 -6.07 -0.35 4.51e-9 Thyroid stimulating hormone; CESC cis rs5753037 0.676 rs6006267 chr22:30216982 C/A cg01021169 chr22:30184971 ASCC2 -0.47 -6.64 -0.38 1.74e-10 Type 1 diabetes; CESC cis rs9915657 0.660 rs982534 chr17:70081366 T/G cg09344028 chr17:70110421 NA 0.38 6.95 0.39 2.89e-11 Thyroid hormone levels; CESC cis rs7116495 1.000 rs659513 chr11:71812411 C/T cg10381502 chr11:71823885 C11orf51 0.72 6.21 0.36 2.06e-9 Severe influenza A (H1N1) infection; CESC cis rs9916302 0.706 rs12947506 chr17:37707592 A/G cg07936489 chr17:37558343 FBXL20 -0.97 -11.4 -0.57 9.06e-25 Glomerular filtration rate (creatinine); CESC cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg08213375 chr14:104286397 PPP1R13B 0.33 5.41 0.32 1.42e-7 Reticulocyte count; CESC trans rs10489896 0.541 rs2065143 chr1:234568613 T/C cg23817893 chr11:86085932 CCDC81 -0.45 -6.21 -0.36 2.04e-9 Cognitive test performance; CESC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg17422500 chr1:249152952 ZNF692 -0.41 -6.28 -0.36 1.36e-9 Vertical cup-disc ratio; CESC cis rs2439831 1.000 rs2253708 chr15:43797273 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.85 12.03 0.59 7.01e-27 Lung cancer in ever smokers; CESC cis rs10752881 0.935 rs10911197 chr1:182995399 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Colorectal cancer; CESC cis rs7259376 0.905 rs7258446 chr19:22550341 A/T cg02657401 chr19:22469223 NA -0.25 -5.05 -0.3 8.18e-7 Menopause (age at onset); CESC cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg02487422 chr3:49467188 NICN1 0.4 5.04 0.3 8.72e-7 Parkinson's disease; CESC cis rs9929218 1.000 rs12930371 chr16:68802936 A/G cg02972257 chr16:68554789 NA -0.44 -5.26 -0.31 2.92e-7 Colorectal cancer; CESC cis rs2204008 0.683 rs11522927 chr12:38137537 C/T cg26384229 chr12:38710491 ALG10B 0.75 10.66 0.55 2.52e-22 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16442450 chr15:69111511 ANP32A 0.55 6.64 0.38 1.79e-10 Gut microbiome composition (summer); CESC cis rs17253792 0.571 rs112129578 chr14:56028415 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.41 0.32 1.38e-7 Putamen volume; CESC cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg12386194 chr3:101231763 SENP7 0.41 5.16 0.3 4.78e-7 Colorectal cancer; CESC cis rs2439831 0.867 rs16957630 chr15:43642780 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.37 0.54 2.22e-21 Lung cancer in ever smokers; CESC cis rs11098499 0.954 rs13151285 chr4:120314741 C/A cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13724827 chr9:126030353 STRBP 0.5 6.67 0.38 1.52e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9926296 0.712 rs2437957 chr16:89715648 G/A cg03605463 chr16:89740564 NA 0.66 7.87 0.44 9.23e-14 Vitiligo; CESC trans rs9929218 0.954 rs7198799 chr16:68818390 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -8.5 -0.46 1.44e-15 Colorectal cancer; CESC cis rs9399401 0.961 rs1342060 chr6:142663177 T/C cg03128060 chr6:142623767 GPR126 0.26 5.07 0.3 7.44e-7 Chronic obstructive pulmonary disease; CESC cis rs4604732 0.631 rs34443739 chr1:247626913 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg00166722 chr3:10149974 C3orf24 0.48 5.92 0.34 9.76e-9 Alzheimer's disease; CESC cis rs6987853 0.933 rs6980507 chr8:42383084 A/G cg09913449 chr8:42400586 C8orf40 0.38 6.03 0.35 5.38e-9 Mean corpuscular hemoglobin concentration; CESC trans rs9858542 1.000 rs2172252 chr3:49678307 A/T cg21659725 chr3:3221576 CRBN -0.53 -6.39 -0.37 7.25e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg08109568 chr15:31115862 NA 0.68 9.49 0.5 1.38e-18 Huntington's disease progression; CESC cis rs9487051 0.676 rs6913093 chr6:109636205 T/C cg01475377 chr6:109611718 NA -0.45 -7.05 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg11890956 chr21:40555474 PSMG1 1.12 18.25 0.75 9.24e-49 Cognitive function; CESC cis rs11792861 0.781 rs11793272 chr9:111762102 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 6.7 0.38 1.23e-10 Menarche (age at onset); CESC cis rs9325144 0.534 rs4882350 chr12:38686979 A/G cg26384229 chr12:38710491 ALG10B 0.58 8.59 0.47 7.74e-16 Morning vs. evening chronotype; CESC cis rs4604732 0.574 rs111928142 chr1:247625229 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.51 0.32 8.54e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs60843830 1.000 rs2290911 chr2:224919 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.86 11.39 0.57 9.82e-25 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs55728055 0.661 rs8139560 chr22:32003798 C/T cg01338084 chr22:32026380 PISD 1.22 8.02 0.44 3.48e-14 Age-related hearing impairment; CESC cis rs3106136 0.837 rs2289186 chr4:95255637 T/G cg11021082 chr4:95130006 SMARCAD1 0.39 5.58 0.32 6.03e-8 Capecitabine sensitivity; CESC trans rs1814175 0.645 rs1851857 chr11:49855589 A/C cg11707556 chr5:10655725 ANKRD33B -0.43 -6.28 -0.36 1.35e-9 Height; CESC cis rs9905704 0.624 rs11652761 chr17:56986095 C/T cg12560992 chr17:57184187 TRIM37 0.62 7.6 0.42 4.98e-13 Testicular germ cell tumor; CESC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg00149659 chr3:10157352 C3orf10 0.71 8.29 0.45 5.85e-15 Alzheimer's disease; CESC cis rs1707322 0.964 rs6675259 chr1:46502295 G/A cg05343316 chr1:45956843 TESK2 -0.49 -5.66 -0.33 3.83e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6940638 0.688 rs9393791 chr6:27132529 C/G cg12292205 chr6:26970375 C6orf41 -0.41 -5.44 -0.32 1.22e-7 Intelligence (multi-trait analysis); CESC cis rs6500395 1.000 rs2354578 chr16:48593298 T/C cg04672837 chr16:48644449 N4BP1 0.51 6.36 0.36 8.56e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs10416265 0.527 rs11084699 chr19:33538393 A/T cg27124370 chr19:33622961 WDR88 0.54 7.38 0.41 1.99e-12 Bone properties (heel); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg10731192 chr6:35436023 RPL10A 0.51 6.17 0.35 2.5e-9 Psoriatic arthritis; CESC cis rs9858542 0.953 rs6803222 chr3:49665976 T/G cg07274523 chr3:49395745 GPX1 0.68 8.59 0.47 7.34e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg00684032 chr4:1343700 KIAA1530 0.34 5.16 0.3 4.89e-7 Longevity; CESC cis rs9768139 0.901 rs56113702 chr7:158117938 C/T cg25566285 chr7:158114605 PTPRN2 -0.52 -8.87 -0.48 1.1e-16 Calcium levels; CESC trans rs921968 0.541 rs687747 chr2:219399627 T/C cg15547669 chr20:2781122 CPXM1 0.35 6.0 0.35 6.31e-9 Mean corpuscular hemoglobin concentration; CESC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.13 0.53 1.35e-20 Prudent dietary pattern; CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03900664 chr4:99917553 METAP1 0.47 5.03 0.3 9.06e-7 Gut microbiome composition (summer); CESC cis rs6062302 0.522 rs2282157 chr20:62227180 C/G cg06363034 chr20:62225388 GMEB2 -0.52 -6.6 -0.38 2.21e-10 Glioblastoma; CESC cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.86 8.47 0.46 1.75e-15 Schizophrenia; CESC cis rs3087591 0.960 rs2952976 chr17:29486152 G/A cg24425628 chr17:29625626 OMG;NF1 0.41 5.13 0.3 5.71e-7 Hip circumference; CESC cis rs559928 0.606 rs11231710 chr11:63925743 A/G cg18225595 chr11:63971243 STIP1 0.65 5.97 0.34 7.73e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs7119 0.717 rs10519167 chr15:77723027 G/T cg17802220 chr15:77601643 NA -0.53 -7.36 -0.41 2.31e-12 Type 2 diabetes; CESC cis rs17270561 0.583 rs12662869 chr6:25784481 A/C cg17691542 chr6:26056736 HIST1H1C -0.47 -6.31 -0.36 1.19e-9 Iron status biomarkers; CESC cis rs34172651 0.583 rs4787649 chr16:24700215 C/T cg04756594 chr16:24857601 SLC5A11 -0.53 -6.79 -0.38 7.37e-11 Intelligence (multi-trait analysis); CESC cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg20476274 chr7:133979776 SLC35B4 0.68 10.07 0.53 2.09e-20 Mean platelet volume; CESC cis rs12618769 0.652 rs72823796 chr2:99227812 C/T cg10123293 chr2:99228465 UNC50 0.4 5.21 0.31 3.72e-7 Bipolar disorder; CESC cis rs4268898 0.686 rs2042468 chr2:24398446 A/T cg06627628 chr2:24431161 ITSN2 0.54 7.25 0.41 4.45e-12 Asthma; CESC cis rs5769765 1.000 rs5770728 chr22:50259984 G/A cg02269571 chr22:50332266 NA 0.46 6.24 0.36 1.76e-9 Schizophrenia; CESC cis rs10276381 0.786 rs10272155 chr7:28246989 A/G cg23620719 chr7:28220237 JAZF1 0.74 7.68 0.43 3.18e-13 Crohn's disease; CESC cis rs7666738 0.606 rs13108868 chr4:99083753 C/T cg24818145 chr4:99064322 C4orf37 0.39 5.13 0.3 5.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6500395 1.000 rs4785536 chr16:48712980 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9900062 0.507 rs7225993 chr17:62708284 C/G cg02097616 chr17:62675921 NA 0.44 5.54 0.32 7.19e-8 QT interval; CESC cis rs2439831 0.850 rs60883262 chr15:44076503 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.83 0.43 1.17e-13 Lung cancer in ever smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11713664 chr1:202995853 NA 0.54 6.42 0.37 6.25e-10 Gut microbiome composition (summer); CESC cis rs7264396 0.790 rs12480622 chr20:34234620 T/G cg23207816 chr20:34252616 CPNE1;RBM12 0.59 6.45 0.37 5.14e-10 Total cholesterol levels; CESC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg06494592 chr3:125709126 NA -0.51 -5.51 -0.32 8.32e-8 Blood pressure (smoking interaction); CESC cis rs6062302 0.522 rs6089929 chr20:62219679 C/T cg06363034 chr20:62225388 GMEB2 -0.52 -6.6 -0.38 2.22e-10 Glioblastoma; CESC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg04546413 chr19:29218101 NA 0.56 7.91 0.44 6.84e-14 Methadone dose in opioid dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24480577 chr20:62169334 PTK6 0.56 6.82 0.39 6.16e-11 Gut microbiome composition (summer); CESC cis rs7202877 0.706 rs2059257 chr16:75396376 G/A cg04384234 chr16:75411784 CFDP1 -0.47 -5.78 -0.33 2.13e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs3768617 0.510 rs4651142 chr1:183097386 A/T ch.1.3577855R chr1:183094577 LAMC1 0.89 14.27 0.66 1.13e-34 Fuchs's corneal dystrophy; CESC cis rs2816062 0.813 rs2816057 chr1:18902257 G/C cg18795169 chr1:18902165 NA -0.94 -17.58 -0.73 2.19e-46 Urate levels in lean individuals; CESC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg17376030 chr22:41985996 PMM1 0.66 7.2 0.4 6.32e-12 Vitiligo; CESC cis rs698833 0.962 rs1067386 chr2:44644257 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.91 0.34 1.02e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs17638544 0.881 rs7326472 chr13:42979951 C/T cg01287592 chr8:142139839 DENND3 0.72 6.09 0.35 3.85e-9 Bone mineral density; CESC cis rs9457247 1.000 rs408040 chr6:167398903 A/T cg23791538 chr6:167370224 RNASET2 -0.59 -8.41 -0.46 2.56e-15 Crohn's disease; CESC cis rs11997175 0.562 rs58955533 chr8:33829692 C/T ch.8.33884649F chr8:33765107 NA 0.46 5.8 0.34 1.86e-8 Body mass index; CESC cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg11752832 chr7:134001865 SLC35B4 0.55 7.23 0.41 5.27e-12 Mean platelet volume; CESC cis rs9308433 0.529 rs6660335 chr1:214501855 C/T cg06198575 chr1:214491504 SMYD2 0.43 5.18 0.3 4.35e-7 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22065367 chr18:60382639 PHLPP1 0.58 6.37 0.36 8.48e-10 Gut microbiome composition (summer); CESC cis rs17376456 0.877 rs7734897 chr5:93305402 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.64 5.63 0.33 4.56e-8 Diabetic retinopathy; CESC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg23283495 chr1:209979779 IRF6 0.51 7.52 0.42 8.25e-13 Cleft lip with or without cleft palate; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04095345 chr6:34857663 ANKS1A -0.43 -6.11 -0.35 3.45e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs61931739 0.500 rs11053274 chr12:34547605 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.51 0.54 8.1e-22 Morning vs. evening chronotype; CESC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg05564831 chr3:52568323 NT5DC2 0.45 7.15 0.4 8.3e-12 Bipolar disorder; CESC cis rs7847628 0.666 rs2031974 chr9:123527521 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.51 6.12 0.35 3.41e-9 Birth weight; CESC cis rs2603127 0.768 rs6797831 chr3:108463025 G/A cg03329597 chr3:108125523 MYH15 0.6 5.42 0.32 1.33e-7 Hemostatic factors and hematological phenotypes; CESC cis rs9815354 0.812 rs10510731 chr3:41853310 C/T cg03022575 chr3:42003672 ULK4 0.7 6.32 0.36 1.08e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7395581 0.918 rs326214 chr11:47298360 G/A cg25783544 chr11:47291846 MADD -0.57 -7.59 -0.42 5.46e-13 HDL cholesterol; CESC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.59 -0.38 2.36e-10 Depression; CESC cis rs12325245 0.536 rs35908812 chr16:58587426 T/C cg01152986 chr16:58549298 SETD6 0.89 5.4 0.32 1.45e-7 Schizophrenia; CESC cis rs428668 0.523 rs3926389 chr5:150677806 C/T cg11125805 chr5:150678162 SLC36A3 0.71 11.3 0.57 1.99e-24 Skin aging (microtopography measurement); CESC cis rs7520050 0.931 rs7526678 chr1:46374159 A/G cg03146154 chr1:46216737 IPP -0.48 -6.19 -0.36 2.33e-9 Red blood cell count;Reticulocyte count; CESC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.16 -0.3 4.89e-7 Lung cancer; CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg10819733 chr22:24237672 NA 0.39 5.57 0.32 6.25e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9325144 0.600 rs12297194 chr12:38735803 A/G cg26384229 chr12:38710491 ALG10B -0.54 -7.83 -0.43 1.14e-13 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 3.92e-7 Colonoscopy-negative controls vs population controls; CESC trans rs5769765 0.773 rs9616383 chr22:50313014 T/C cg09872104 chr7:134855509 C7orf49 -0.55 -6.31 -0.36 1.19e-9 Schizophrenia; CESC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg13918804 chr1:2043761 PRKCZ 0.27 5.26 0.31 3e-7 Height; CESC cis rs34421088 0.678 rs35726503 chr8:11591916 A/T cg13293535 chr8:11597251 GATA4 0.3 5.7 0.33 3.26e-8 Neuroticism; CESC cis rs858239 0.862 rs1728292 chr7:23263474 C/G cg23682824 chr7:23144976 KLHL7 0.43 5.77 0.33 2.16e-8 Cerebrospinal fluid biomarker levels; CESC cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg06212747 chr3:49208901 KLHDC8B 0.66 8.74 0.47 2.71e-16 Parkinson's disease; CESC cis rs2228479 0.867 rs12930056 chr16:89946649 C/A cg00800038 chr16:89945340 TCF25 -0.88 -7.85 -0.43 1.01e-13 Skin colour saturation; CESC cis rs7927771 1.000 rs4752873 chr11:47857520 C/T cg18512352 chr11:47633146 NA -0.6 -9.57 -0.51 8.16e-19 Subjective well-being; CESC cis rs62283056 0.636 rs62283057 chr4:6276805 C/T cg00701064 chr4:6280414 WFS1 -0.58 -5.34 -0.31 1.95e-7 Cisplatin-induced ototoxicity; CESC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg18876405 chr7:65276391 NA 0.51 5.96 0.34 8.21e-9 Aortic root size; CESC cis rs9902453 1.000 rs9891871 chr17:28370191 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.09e-13 Coffee consumption (cups per day); CESC cis rs7084402 0.967 rs2917949 chr10:60329166 G/A cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs1475911 1.000 rs17114359 chr21:43510437 A/C cg24372256 chr21:43528868 UMODL1;C21orf128 -0.41 -5.88 -0.34 1.22e-8 IgG glycosylation; CESC cis rs2353275 0.655 rs7080866 chr10:88152150 C/T cg07322936 chr10:88137208 NA 1.04 6.26 0.36 1.54e-9 Asthma (childhood onset);Asthma; CESC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg24531977 chr5:56204891 C5orf35 0.71 9.52 0.5 1.11e-18 Initial pursuit acceleration; CESC cis rs7084402 0.529 rs7912116 chr10:60335389 G/C cg07615347 chr10:60278583 BICC1 0.4 5.83 0.34 1.57e-8 Refractive error; CESC cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.08 0.3 7.23e-7 Hip circumference adjusted for BMI; CESC cis rs2012796 0.785 rs61986593 chr14:81840659 G/A cg02996355 chr14:81879375 NA 0.67 8.11 0.45 1.91e-14 Night sleep phenotypes; CESC cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg27266027 chr21:40555129 PSMG1 0.43 5.08 0.3 7.22e-7 Cognitive function; CESC cis rs12681366 0.537 rs10956914 chr8:95483723 G/T cg13257157 chr8:95487014 RAD54B -0.43 -5.25 -0.31 3.11e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs12477438 0.765 rs2309521 chr2:99592069 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs116095464 0.558 rs2288457 chr5:231270 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.22 0.31 3.68e-7 Breast cancer; CESC cis rs763014 0.833 rs916415 chr16:632115 G/A cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg25036284 chr2:26402008 FAM59B -0.86 -9.36 -0.5 3.44e-18 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg24642844 chr7:1081250 C7orf50 -0.74 -8.9 -0.48 8.74e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg07648498 chr16:89883185 FANCA 0.46 5.62 0.33 4.84e-8 Vitiligo; CESC cis rs344364 0.511 rs1742462 chr16:1946062 A/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs2637266 1.000 rs1907317 chr10:78337849 C/A cg18941641 chr10:78392320 NA 0.42 7.61 0.42 4.9e-13 Pulmonary function; CESC cis rs7851660 0.967 rs13288000 chr9:100608980 A/G cg13688889 chr9:100608707 NA -0.69 -10.7 -0.55 1.96e-22 Strep throat; CESC cis rs3091242 0.933 rs932372 chr1:25755014 G/A cg03538708 chr1:25844672 NA -0.42 -6.4 -0.37 6.9e-10 Erythrocyte sedimentation rate; CESC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg18099408 chr3:52552593 STAB1 -0.3 -5.09 -0.3 6.67e-7 Bipolar disorder; CESC cis rs735396 0.770 rs1169315 chr12:121443753 T/G cg25281562 chr12:121454272 C12orf43 0.52 6.5 0.37 3.91e-10 N-glycan levels; CESC cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg00745463 chr17:30367425 LRRC37B -0.83 -7.62 -0.42 4.42e-13 Hip circumference adjusted for BMI; CESC cis rs6495122 0.699 rs1378941 chr15:75080150 C/A cg09165964 chr15:75287851 SCAMP5 0.4 5.23 0.31 3.46e-7 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC trans rs2727020 0.521 rs11039902 chr11:48679467 A/G cg00717180 chr2:96193071 NA -0.44 -6.01 -0.35 6e-9 Coronary artery disease; CESC cis rs977987 0.815 rs11646677 chr16:75408981 T/C cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.78e-8 Dupuytren's disease; CESC cis rs6831352 0.918 rs7689753 chr4:100055575 A/G cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26880806 chr2:98262454 COX5B 0.58 6.09 0.35 3.86e-9 Gut microbiome composition (summer); CESC cis rs2439831 1.000 rs2444032 chr15:43755346 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.83 11.98 0.59 1.04e-26 Lung cancer in ever smokers; CESC trans rs6951245 0.608 rs10252234 chr7:1114381 C/T cg13565492 chr6:43139072 SRF -0.54 -6.07 -0.35 4.44e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs820218 0.926 rs820206 chr17:73641714 G/A cg01592526 chr17:73663357 RECQL5;SAP30BP 0.42 5.48 0.32 9.69e-8 Rotator cuff tears; CESC cis rs2228479 0.702 rs3819574 chr16:89826630 G/A cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.76e-18 Skin colour saturation; CESC cis rs6714710 0.603 rs35255677 chr2:98567820 G/A cg26665480 chr2:98280029 ACTR1B 0.59 8.04 0.44 2.97e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs9863 0.861 rs3789967 chr12:124447339 T/G cg00084347 chr12:124393913 DNAH10 0.27 5.3 0.31 2.46e-7 White blood cell count; CESC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg25072359 chr17:41440525 NA 0.43 5.83 0.34 1.61e-8 Menopause (age at onset); CESC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg15782153 chr7:917662 C7orf20 0.48 5.29 0.31 2.57e-7 Cerebrospinal P-tau181p levels; CESC cis rs7223966 1.000 rs8075257 chr17:61728750 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.16 0.4 8.13e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs12220238 0.915 rs10824074 chr10:75876457 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.66 6.56 0.37 2.83e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs501120 1.000 rs607760 chr10:44756236 A/G cg09554077 chr10:44749378 NA 0.53 6.85 0.39 5.25e-11 Coronary artery disease;Coronary heart disease; CESC cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg07697082 chr8:82753677 SNX16 -0.39 -5.32 -0.31 2.19e-7 Diastolic blood pressure; CESC cis rs10752881 0.743 rs10737244 chr1:183098417 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Colorectal cancer; CESC cis rs11696501 0.688 rs8123346 chr20:44309987 A/T cg11783356 chr20:44313418 WFDC10B -0.33 -5.25 -0.31 3.07e-7 Brain structure; CESC cis rs1046896 0.503 rs12947062 chr17:80686370 A/G cg02711726 chr17:80685570 FN3KRP 0.6 9.12 0.49 1.91e-17 Glycated hemoglobin levels; CESC cis rs8017423 0.904 rs11848894 chr14:90723660 C/A cg14092571 chr14:90743983 NA -0.55 -8.31 -0.45 5.06e-15 Mortality in heart failure; CESC cis rs11958404 0.932 rs113494689 chr5:157428078 G/T cg05962755 chr5:157440814 NA 0.59 6.45 0.37 5.28e-10 IgG glycosylation; CESC cis rs6460942 0.915 rs62447642 chr7:12489147 T/C cg20607287 chr7:12443886 VWDE -0.77 -8.71 -0.47 3.35e-16 Coronary artery disease; CESC cis rs4253772 0.637 rs9627350 chr22:46663017 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.68 8.04 0.44 3.08e-14 LDL cholesterol;Cholesterol, total; CESC cis rs941408 0.515 rs1005556 chr19:2778543 G/T cg02580895 chr19:2754563 NA -0.48 -6.7 -0.38 1.27e-10 Total cholesterol levels; CESC cis rs3087591 0.887 rs12150521 chr17:29595108 C/T cg24425628 chr17:29625626 OMG;NF1 0.47 6.04 0.35 5.07e-9 Hip circumference; CESC cis rs2652822 0.935 rs2292038 chr15:63449680 C/G cg02713581 chr15:63449717 RPS27L -0.59 -7.72 -0.43 2.41e-13 Metabolic traits; CESC cis rs228769 0.562 rs228779 chr17:42091213 A/G cg19774624 chr17:42201019 HDAC5 0.51 5.66 0.33 3.93e-8 Bone mineral density (hip);Bone mineral density (spine); CESC cis rs11649653 0.502 rs4889490 chr16:30823047 A/C cg00531865 chr16:30841666 NA -0.43 -5.49 -0.32 9.52e-8 Triglycerides; CESC cis rs2795502 1.000 rs1852959 chr10:43359636 T/C cg27426351 chr10:43362370 NA 0.49 6.09 0.35 4.06e-9 Blood protein levels; CESC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs9457247 0.967 rs1211447 chr6:167381979 C/T cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 5.12e-16 Crohn's disease; CESC cis rs2463822 1.000 rs72921501 chr11:62115622 A/T cg06239285 chr11:62104954 ASRGL1 -0.99 -8.49 -0.46 1.48e-15 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs629535 0.814 rs78813708 chr8:70073977 A/G cg21567404 chr3:27674614 NA 0.86 10.06 0.53 2.32e-20 Dupuytren's disease; CESC cis rs9300255 0.602 rs1616131 chr12:123619838 G/A cg00376283 chr12:123451042 ABCB9 0.71 8.71 0.47 3.37e-16 Neutrophil percentage of white cells; CESC cis rs2228479 0.702 rs11076621 chr16:89837927 A/G cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg07092213 chr7:1199455 ZFAND2A -0.42 -5.75 -0.33 2.48e-8 Longevity;Endometriosis; CESC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg22143856 chr6:28129313 ZNF389 0.52 6.76 0.38 8.79e-11 Depression; CESC cis rs897984 0.609 rs11862744 chr16:31057800 G/A cg02466173 chr16:30829666 NA -0.39 -6.77 -0.38 8.15e-11 Dementia with Lewy bodies; CESC cis rs2070997 0.607 rs4504691 chr9:133663852 T/C cg11464064 chr9:133710261 ABL1 0.58 6.8 0.39 6.9e-11 Response to amphetamines; CESC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -6.76 -0.38 8.51e-11 Bipolar disorder; CESC cis rs12142240 0.698 rs17357635 chr1:46808668 G/A cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs7208859 0.623 rs7220999 chr17:29149298 C/T cg19761014 chr17:28927070 LRRC37B2 0.79 6.47 0.37 4.6e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2354432 0.505 rs72691009 chr1:146708397 C/T cg25205988 chr1:146714368 CHD1L -1.02 -8.03 -0.44 3.16e-14 Mitochondrial DNA levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14518868 chr12:69864352 FRS2 0.53 6.16 0.35 2.71e-9 Gut microbiome composition (summer); CESC cis rs4899260 0.911 rs194713 chr14:69295469 T/C cg03189333 chr14:69283534 NA 0.47 5.13 0.3 5.5e-7 Celiac disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26071963 chr14:88945568 PTPN21 -0.58 -6.43 -0.37 5.99e-10 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg15017067 chr4:17643749 FAM184B 0.41 5.82 0.34 1.7e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs902774 0.515 rs2363635 chr12:53354622 T/C cg14581129 chr12:53358946 NA -0.52 -7.01 -0.4 2.01e-11 Prostate cancer; CESC cis rs4925386 1.000 rs4925389 chr20:60922512 G/A cg24112000 chr20:60950667 NA 0.51 7.42 0.41 1.62e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg15254786 chr2:207630414 MDH1B;FASTKD2 0.47 6.16 0.35 2.75e-9 Tetralogy of Fallot; CESC cis rs4604732 0.527 rs60444724 chr1:247623164 T/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.46 0.37 5.02e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs5753618 0.583 rs8141150 chr22:31800336 C/T cg13145458 chr22:31556086 RNF185 -0.49 -5.83 -0.34 1.62e-8 Colorectal cancer; CESC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.87 0.44 8.87e-14 Electroencephalogram traits; CESC cis rs77956314 0.515 rs10850733 chr12:117380961 G/A cg02017074 chr12:117425053 FBXW8 0.8 8.81 0.48 1.69e-16 Subcortical brain region volumes;Hippocampal volume; CESC cis rs453301 0.653 rs2956244 chr8:8885166 A/G cg15556689 chr8:8085844 FLJ10661 0.49 6.3 0.36 1.22e-9 Joint mobility (Beighton score); CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg15908398 chr12:112037868 ATXN2 0.5 6.4 0.37 7.03e-10 Retinol levels; CESC cis rs72781680 0.559 rs72796103 chr2:23900382 G/A cg20701182 chr2:24300061 SF3B14 0.8 6.92 0.39 3.33e-11 Lymphocyte counts; CESC cis rs965513 1.000 rs7030241 chr9:100550375 T/A cg13688889 chr9:100608707 NA -0.6 -8.62 -0.47 6.31e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs911555 0.755 rs12436729 chr14:103929889 G/C cg24130564 chr14:104152367 KLC1 0.49 6.32 0.36 1.11e-9 Intelligence (multi-trait analysis); CESC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg15445000 chr17:37608096 MED1 0.4 6.47 0.37 4.81e-10 Glomerular filtration rate (creatinine); CESC cis rs17641971 0.684 rs4873310 chr8:49990006 A/T cg00325661 chr8:49890786 NA 0.39 5.5 0.32 8.94e-8 Blood metabolite levels; CESC cis rs887829 0.569 rs10179091 chr2:234657983 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -6.02 -0.35 5.88e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs2637266 0.935 rs7921790 chr10:78368253 T/C cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC cis rs7512552 0.646 rs1694367 chr1:150329469 T/A cg15654264 chr1:150340011 RPRD2 0.39 5.24 0.31 3.25e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg11764359 chr7:65958608 NA 0.6 7.4 0.41 1.85e-12 Calcium levels; CESC cis rs694739 1.000 rs1783521 chr11:64106291 T/C cg23796481 chr11:64053134 BAD;GPR137 0.66 8.5 0.46 1.36e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs2732480 0.537 rs1061986 chr12:48736439 T/C cg04545296 chr12:48745243 ZNF641 0.44 7.22 0.41 5.44e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg19318889 chr4:1322082 MAEA 0.43 5.96 0.34 8.03e-9 Longevity; CESC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg00933542 chr6:150070202 PCMT1 0.3 5.26 0.31 2.96e-7 Lung cancer; CESC cis rs7223966 1.000 rs7211213 chr17:61769456 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.47 -5.76 -0.33 2.37e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9611565 0.559 rs7290990 chr22:41964357 C/A cg03806693 chr22:41940476 POLR3H -0.97 -12.07 -0.6 4.96e-27 Vitiligo; CESC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg18099408 chr3:52552593 STAB1 -0.3 -5.14 -0.3 5.45e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26216002 chr1:10093067 UBE4B -0.53 -6.14 -0.35 2.96e-9 Gut microbiome composition (summer); CESC cis rs8072100 0.713 rs9807106 chr17:45457102 G/T cg08085267 chr17:45401833 C17orf57 -0.51 -6.49 -0.37 4.12e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs2727020 0.636 rs10839275 chr11:49438962 T/A cg03929089 chr4:120376271 NA -0.81 -12.55 -0.61 1.11e-28 Coronary artery disease; CESC cis rs911555 0.755 rs35233301 chr14:103885291 A/G cg24130564 chr14:104152367 KLC1 0.49 6.36 0.36 9e-10 Intelligence (multi-trait analysis); CESC trans rs1814175 0.588 rs1794144 chr11:49918233 A/G cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs4888262 0.508 rs7189123 chr16:74540097 C/A cg01733217 chr16:74700730 RFWD3 0.81 11.31 0.57 1.89e-24 Testicular germ cell tumor; CESC trans rs9858542 0.903 rs9875617 chr3:49634696 G/A cg21659725 chr3:3221576 CRBN -0.53 -6.46 -0.37 4.86e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2635047 0.638 rs2571006 chr18:44718515 G/T cg24371990 chr18:44770781 NA 0.32 5.06 0.3 7.89e-7 Educational attainment; CESC trans rs1814175 0.645 rs1721995 chr11:49915488 A/G cg03929089 chr4:120376271 NA -0.89 -14.83 -0.67 1.17e-36 Height; CESC cis rs2933343 0.621 rs789242 chr3:128585707 T/C cg24203234 chr3:128598194 ACAD9 0.38 5.14 0.3 5.33e-7 IgG glycosylation; CESC cis rs12541635 0.639 rs10955408 chr8:107020789 G/A cg10147462 chr8:107024639 NA 0.47 7.08 0.4 1.27e-11 Age of smoking initiation; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18756868 chr18:19284803 ABHD3 -0.49 -6.13 -0.35 3.24e-9 Ulcerative colitis; CESC cis rs6665290 0.904 rs2297418 chr1:227192579 A/C cg10327440 chr1:227177885 CDC42BPA -1.22 -32.59 -0.89 1.07e-94 Myeloid white cell count; CESC cis rs55823223 0.648 rs936394 chr17:73852008 C/A cg08125733 chr17:73851984 WBP2 0.91 11.81 0.59 3.71e-26 Psoriasis; CESC cis rs4595586 0.756 rs7137139 chr12:39364013 C/T cg26384229 chr12:38710491 ALG10B 0.42 6.05 0.35 4.8e-9 Morning vs. evening chronotype; CESC cis rs1023500 0.573 rs133377 chr22:42466950 C/T cg15557168 chr22:42548783 NA -0.45 -6.3 -0.36 1.26e-9 Schizophrenia; CESC cis rs2455799 0.573 rs2470523 chr3:15768091 G/C cg16303742 chr3:15540471 COLQ -0.39 -6.24 -0.36 1.76e-9 Mean platelet volume; CESC cis rs9549367 0.713 rs4907598 chr13:113861385 C/T cg18105134 chr13:113819100 PROZ 0.55 7.39 0.41 1.87e-12 Platelet distribution width; CESC cis rs4953076 0.573 rs7595470 chr2:44402467 A/G cg04920474 chr2:44395004 PPM1B 0.55 7.09 0.4 1.23e-11 Height; CESC cis rs6540559 0.611 rs61747285 chr1:210004332 G/A cg22029157 chr1:209979665 IRF6 0.71 7.61 0.42 4.72e-13 Cleft lip with or without cleft palate; CESC cis rs7851660 0.809 rs7034249 chr9:100653821 C/T cg13688889 chr9:100608707 NA -0.63 -8.96 -0.48 5.96e-17 Strep throat; CESC cis rs6484504 0.625 rs796341 chr11:31414151 G/A cg14844989 chr11:31128820 NA 0.39 5.58 0.32 6.03e-8 Red blood cell count; CESC cis rs3096299 1.000 rs3096299 chr16:89448663 G/A cg16743903 chr16:89593216 SPG7 -0.42 -5.36 -0.31 1.82e-7 Multiple myeloma (IgH translocation); CESC cis rs919433 0.889 rs787998 chr2:198216092 A/G cg03934865 chr2:198174659 NA 0.45 6.81 0.39 6.4e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs933688 1.000 rs1964292 chr5:90743608 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 12.13 0.6 3.17e-27 Smoking behavior; CESC cis rs7208859 0.524 rs8069400 chr17:29075967 G/T cg19761014 chr17:28927070 LRRC37B2 0.81 6.64 0.38 1.81e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10045504 0.502 rs17352898 chr5:38745498 C/T cg15396434 chr5:38725168 NA -0.73 -6.82 -0.39 6.32e-11 Night sleep phenotypes; CESC cis rs1559088 0.576 rs7251626 chr19:33578470 C/A cg17764715 chr19:33622953 WDR88 0.59 8.48 0.46 1.61e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07853919 chr18:77711868 PQLC1 0.55 7.01 0.4 1.97e-11 Gut microbiome composition (summer); CESC trans rs35110281 0.626 rs162367 chr21:44934857 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 6.11 0.35 3.58e-9 Mean corpuscular volume; CESC trans rs2016266 0.929 rs7486393 chr12:53652885 C/T cg08421126 chr2:43019854 HAAO -0.46 -6.1 -0.35 3.83e-9 Bone mineral density (spine);Bone mineral density; CESC cis rs9815354 1.000 rs9823254 chr3:41894768 G/C cg03022575 chr3:42003672 ULK4 0.58 5.94 0.34 9.04e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs57221529 0.766 rs72703065 chr5:588123 C/A cg25482853 chr8:67687455 SGK3 1.01 9.99 0.52 3.67e-20 Lung disease severity in cystic fibrosis; CESC cis rs6912958 0.500 rs2025486 chr6:87796886 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -7.84 -0.43 1.12e-13 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08467400 chr7:44646271 OGDH 0.69 7.91 0.44 6.94e-14 Gut microbiome composition (summer); CESC cis rs2816062 0.813 rs2816053 chr1:18895819 A/G cg18795169 chr1:18902165 NA -0.91 -17.81 -0.74 3.44e-47 Urate levels in lean individuals; CESC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.86 9.12 0.49 1.95e-17 Platelet count; CESC cis rs6831352 0.801 rs2602897 chr4:100046293 A/T cg12011299 chr4:100065546 ADH4 0.59 6.52 0.37 3.62e-10 Alcohol dependence; CESC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.73 0.33 2.7e-8 Electroencephalogram traits; CESC cis rs5769765 0.704 rs138837 chr22:50180714 A/G cg02269571 chr22:50332266 NA -0.46 -5.94 -0.34 9.04e-9 Schizophrenia; CESC cis rs977987 0.843 rs4888415 chr16:75448921 C/T cg03315344 chr16:75512273 CHST6 0.42 6.11 0.35 3.62e-9 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21150049 chr12:50677498 LIMA1 0.56 6.68 0.38 1.42e-10 Gut microbiome composition (summer); CESC cis rs6582630 0.519 rs12582285 chr12:38298753 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Depression; CESC cis rs62432291 0.681 rs404461 chr6:159640709 T/C cg14500486 chr6:159655392 FNDC1 0.57 5.73 0.33 2.68e-8 Joint mobility (Beighton score); CESC cis rs1124376 0.935 rs9855900 chr3:20147172 C/T cg05072819 chr3:20081367 KAT2B 0.47 5.14 0.3 5.39e-7 Bipolar disorder and schizophrenia; CESC cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg06212747 chr3:49208901 KLHDC8B 0.74 9.72 0.51 2.73e-19 Parkinson's disease; CESC cis rs2985684 0.948 rs11623263 chr14:50083295 A/G cg02151108 chr14:50098012 C14orf104 -0.41 -5.4 -0.31 1.51e-7 Carotid intima media thickness; CESC cis rs4595586 0.679 rs1878228 chr12:39355595 T/C cg26384229 chr12:38710491 ALG10B 0.42 6.07 0.35 4.3e-9 Morning vs. evening chronotype; CESC trans rs7618501 0.633 rs2526751 chr3:50064867 T/C cg21659725 chr3:3221576 CRBN -0.53 -7.45 -0.42 1.33e-12 Intelligence (multi-trait analysis); CESC cis rs728616 0.867 rs116994688 chr10:81738137 G/C cg05935833 chr10:81318306 SFTPA2 -0.52 -5.06 -0.3 7.72e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6963495 0.818 rs6973974 chr7:105170629 C/T cg19920283 chr7:105172520 RINT1 0.69 6.54 0.37 3.15e-10 Bipolar disorder (body mass index interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00322698 chr6:41069048 NFYA;LOC221442 -0.62 -7.0 -0.4 2.09e-11 Gut microbiome composition (summer); CESC cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg14345882 chr6:26364793 BTN3A2 0.41 5.35 0.31 1.94e-7 Intelligence (multi-trait analysis); CESC cis rs34779708 0.766 rs7913451 chr10:35551525 T/C cg03585969 chr10:35415529 CREM 0.54 6.14 0.35 2.99e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs2228479 0.850 rs11644526 chr16:89898660 C/T cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg23131131 chr22:24373011 LOC391322 0.64 8.8 0.48 1.76e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7582720 0.943 rs72932559 chr2:203847382 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05694744 chr17:8191820 RANGRF;SLC25A35 -0.49 -6.44 -0.37 5.66e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2204008 0.837 rs11612125 chr12:38213212 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg02487422 chr3:49467188 NICN1 0.38 5.17 0.3 4.51e-7 Menarche (age at onset); CESC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg05863683 chr7:1912471 MAD1L1 0.45 6.75 0.38 9.09e-11 Bipolar disorder and schizophrenia; CESC cis rs5769765 1.000 rs768619 chr22:50287266 C/T cg02269571 chr22:50332266 NA -0.46 -6.26 -0.36 1.53e-9 Schizophrenia; CESC cis rs959260 1.000 rs959260 chr17:73369422 C/T cg12999837 chr17:73267436 MIF4GD -0.47 -5.5 -0.32 8.8e-8 Systemic lupus erythematosus; CESC cis rs2769264 0.546 rs12047617 chr1:151392597 G/A cg18801370 chr1:151430492 POGZ 0.55 6.9 0.39 3.8e-11 Blood trace element (Cu levels); CESC cis rs992157 0.835 rs4674283 chr2:219144254 G/A cg00012203 chr2:219082015 ARPC2 -0.76 -9.55 -0.51 9.45e-19 Colorectal cancer; CESC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs1670533 1.000 rs6837145 chr4:1071067 T/C cg27284194 chr4:1044797 NA 0.45 5.76 0.33 2.27e-8 Recombination rate (females); CESC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg27170947 chr2:26402098 FAM59B -0.84 -10.08 -0.53 1.98e-20 Gut microbiome composition (summer); CESC trans rs7246760 0.867 rs2336089 chr19:9849972 C/T cg02900749 chr2:68251473 NA -0.84 -7.32 -0.41 2.99e-12 Pursuit maintenance gain; CESC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg26338869 chr17:61819248 STRADA 0.67 8.66 0.47 4.55e-16 Prudent dietary pattern; CESC cis rs3749237 0.576 rs3877784 chr3:49539417 C/T cg07636037 chr3:49044803 WDR6 0.61 8.81 0.48 1.66e-16 Resting heart rate; CESC cis rs748404 0.578 rs552701 chr15:43613810 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.6 8.0 0.44 3.9e-14 Lung cancer; CESC trans rs2727020 0.688 rs11040338 chr11:49360601 A/G cg03929089 chr4:120376271 NA 0.79 11.98 0.59 1.01e-26 Coronary artery disease; CESC cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg20476274 chr7:133979776 SLC35B4 0.66 9.48 0.5 1.52e-18 Mean platelet volume; CESC cis rs12410462 0.681 rs6682883 chr1:227635598 G/A cg04117972 chr1:227635322 NA 0.75 6.71 0.38 1.18e-10 Major depressive disorder; CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg24846343 chr22:24311635 DDTL -0.65 -11.02 -0.56 1.66e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg26879891 chr1:152191343 HRNR -0.42 -6.57 -0.37 2.71e-10 Inflammatory skin disease; CESC cis rs4975616 0.714 rs37007 chr5:1352372 G/C cg26373071 chr5:1325741 CLPTM1L 0.45 7.11 0.4 1.1e-11 Lung cancer; CESC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg18337363 chr3:52569053 NT5DC2 0.31 5.24 0.31 3.31e-7 Bipolar disorder; CESC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg14393609 chr7:65229607 NA -0.48 -6.31 -0.36 1.18e-9 Aortic root size; CESC cis rs599083 0.573 rs3018713 chr11:68390986 A/G cg16797656 chr11:68205561 LRP5 0.49 7.44 0.42 1.4e-12 Bone mineral density (spine); CESC cis rs4689388 0.750 rs10755148 chr4:6295064 A/G cg00701064 chr4:6280414 WFS1 0.65 9.71 0.51 2.92e-19 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg07507251 chr3:52567010 NT5DC2 0.4 6.96 0.39 2.7e-11 Bipolar disorder; CESC cis rs12995491 0.933 rs12995212 chr2:88527184 C/T cg14558114 chr2:88469736 THNSL2 -0.47 -6.71 -0.38 1.2e-10 Response to metformin (IC50); CESC cis rs10256972 0.528 rs7784607 chr7:1178694 A/G cg07308232 chr7:1071921 C7orf50 -0.42 -5.66 -0.33 3.97e-8 Longevity;Endometriosis; CESC cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg18876405 chr7:65276391 NA -0.48 -5.4 -0.31 1.47e-7 Aortic root size; CESC trans rs17685 0.753 rs11982200 chr7:75714883 T/C cg19862616 chr7:65841803 NCRNA00174 0.87 12.7 0.62 3.58e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg25036284 chr2:26402008 FAM59B 0.83 9.07 0.49 2.67e-17 Gut microbiome composition (summer); CESC cis rs258892 0.895 rs463250 chr5:72144463 G/C cg21869765 chr5:72125136 TNPO1 0.43 5.43 0.32 1.26e-7 Small cell lung carcinoma; CESC cis rs6430585 0.759 rs4954623 chr2:136535876 G/A cg07169764 chr2:136633963 MCM6 -1.17 -16.7 -0.72 2.81e-43 Corneal structure; CESC cis rs71277158 0.688 rs2255256 chr3:169785903 G/A cg04067573 chr3:169899625 PHC3 0.72 7.1 0.4 1.16e-11 Prostate cancer; CESC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg18357526 chr6:26021779 HIST1H4A 0.77 10.81 0.55 8.06e-23 Intelligence (multi-trait analysis); CESC cis rs7188697 0.922 rs37053 chr16:58558707 T/C cg21335942 chr16:58549945 SETD6 0.47 5.5 0.32 9.04e-8 QT interval; CESC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg24642844 chr7:1081250 C7orf50 -0.65 -8.14 -0.45 1.54e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2952156 0.920 rs732083 chr17:37834367 G/A cg07936489 chr17:37558343 FBXL20 -0.61 -8.16 -0.45 1.39e-14 Asthma; CESC cis rs34779708 0.931 rs11597483 chr10:35285117 A/G cg03585969 chr10:35415529 CREM 0.77 10.3 0.53 3.84e-21 Inflammatory bowel disease;Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11437374 chr5:169010780 CCDC99 -0.45 -6.3 -0.36 1.24e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2880765 0.835 rs4536419 chr15:86039471 C/T cg10818794 chr15:86012489 AKAP13 -0.35 -5.46 -0.32 1.07e-7 Coronary artery disease; CESC trans rs7726839 0.574 rs11739866 chr5:636299 C/T cg25482853 chr8:67687455 SGK3 1.0 9.64 0.51 4.75e-19 Obesity-related traits; CESC cis rs9611565 0.802 rs4822028 chr22:41789408 A/G cg06634786 chr22:41940651 POLR3H -0.63 -6.86 -0.39 4.77e-11 Vitiligo; CESC cis rs7267979 0.873 rs6115093 chr20:25210730 C/T cg08601574 chr20:25228251 PYGB 0.44 6.12 0.35 3.41e-9 Liver enzyme levels (alkaline phosphatase); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12958836 chr12:8185024 FOXJ2 -0.42 -6.0 -0.35 6.45e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12616745 chr2:191273000 MFSD6 0.53 6.04 0.35 5.3e-9 Gut microbiome composition (summer); CESC cis rs17376456 1.000 rs17323433 chr5:93551028 G/A cg25358565 chr5:93447407 FAM172A 1.15 11.09 0.56 1.02e-23 Diabetic retinopathy; CESC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.81e-11 Glomerular filtration rate (creatinine); CESC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg25838465 chr1:92012736 NA -0.62 -8.93 -0.48 7.55e-17 Breast cancer; CESC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg11764359 chr7:65958608 NA 0.67 8.62 0.47 6.29e-16 Aortic root size; CESC trans rs35110281 0.713 rs1378079 chr21:45011187 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.46 6.13 0.35 3.22e-9 Mean corpuscular volume; CESC cis rs4629710 0.645 rs34601891 chr6:131551238 C/T cg12606694 chr6:131520996 AKAP7 0.48 5.92 0.34 9.77e-9 Multiple myeloma (IgH translocation); CESC trans rs6951245 0.554 rs35126802 chr7:1134842 C/T cg13565492 chr6:43139072 SRF -0.72 -8.79 -0.48 1.98e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs116095464 0.558 rs11959126 chr5:283880 T/G cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.77e-15 Breast cancer; CESC trans rs12265790 1.000 rs11253673 chr10:15928921 G/A cg03460745 chr3:171966142 FNDC3B 0.75 6.02 0.35 5.81e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; CESC cis rs116095464 0.558 rs13357299 chr5:242211 T/C cg20965017 chr5:231967 SDHA -0.45 -5.18 -0.3 4.46e-7 Breast cancer; CESC cis rs2066819 1.000 rs76430365 chr12:56699993 A/C cg26714650 chr12:56694279 CS -1.48 -9.9 -0.52 7.03e-20 Psoriasis vulgaris; CESC cis rs1023500 0.505 rs134899 chr22:42683030 T/G cg15557168 chr22:42548783 NA -0.44 -6.85 -0.39 5.27e-11 Schizophrenia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10671167 chr7:39988923 CDK13 0.5 6.79 0.38 7.42e-11 Systemic lupus erythematosus; CESC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg13206674 chr6:150067644 NUP43 0.41 5.74 0.33 2.62e-8 Lung cancer; CESC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg12463550 chr7:65579703 CRCP -0.49 -6.42 -0.37 6.41e-10 Aortic root size; CESC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg26939375 chr7:64535504 NA 0.76 10.85 0.55 6.19e-23 Aortic root size; CESC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg22974920 chr21:40686053 BRWD1 0.48 5.47 0.32 1.06e-7 Cognitive function; CESC cis rs7772486 0.738 rs2246334 chr6:146183635 G/A cg23711669 chr6:146136114 FBXO30 1.0 14.88 0.67 8.44e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs61931739 0.517 rs11053063 chr12:34181011 C/T cg19457237 chr12:34500585 NA -0.39 -5.39 -0.31 1.53e-7 Morning vs. evening chronotype; CESC cis rs477692 0.692 rs7905095 chr10:131448143 C/T cg05714579 chr10:131428358 MGMT -0.59 -8.34 -0.46 3.98e-15 Response to temozolomide; CESC cis rs2806561 0.704 rs667330 chr1:23515257 A/G cg12483005 chr1:23474871 LUZP1 0.38 6.0 0.35 6.44e-9 Height; CESC cis rs5753618 0.509 rs4820951 chr22:31586248 G/A cg13145458 chr22:31556086 RNF185 0.49 5.52 0.32 7.94e-8 Colorectal cancer; CESC cis rs910316 0.763 rs13712 chr14:75483812 T/C cg08847533 chr14:75593920 NEK9 0.92 16.82 0.72 1.12e-43 Height; CESC cis rs643506 1.000 rs1788955 chr11:111630998 C/G cg17089665 chr11:111648010 NA -0.37 -5.22 -0.31 3.55e-7 Breast cancer; CESC cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg16339924 chr4:17578868 LAP3 0.74 9.66 0.51 4.03e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1707322 0.752 rs11211168 chr1:46163647 C/T cg05343316 chr1:45956843 TESK2 0.51 6.26 0.36 1.54e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg18337363 chr3:52569053 NT5DC2 0.28 5.13 0.3 5.53e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22998610 chr11:62538411 TAF6L 0.56 6.86 0.39 4.94e-11 Gut microbiome composition (summer); CESC cis rs514406 0.893 rs1242315 chr1:53417181 A/G cg24675658 chr1:53192096 ZYG11B -0.53 -6.4 -0.37 6.86e-10 Monocyte count; CESC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg23262073 chr20:60523788 NA -0.38 -5.15 -0.3 5.03e-7 Body mass index; CESC cis rs950169 0.919 rs12915589 chr15:84734464 T/C cg17507749 chr15:85114479 UBE2QP1 0.64 7.1 0.4 1.17e-11 Schizophrenia; CESC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs4481887 1.000 rs4306162 chr1:248468509 C/T cg00666640 chr1:248458726 OR2T12 0.39 6.36 0.36 8.71e-10 Common traits (Other); CESC cis rs7635838 0.859 rs9875414 chr3:11453559 A/G cg00170343 chr3:11313890 ATG7 0.42 5.55 0.32 6.87e-8 HDL cholesterol; CESC cis rs11792861 0.926 rs58795279 chr9:111851902 A/T cg05043794 chr9:111880884 C9orf5 -0.41 -6.86 -0.39 4.76e-11 Menarche (age at onset); CESC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg19717773 chr7:2847554 GNA12 -0.56 -7.74 -0.43 2.11e-13 Height; CESC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg04369109 chr6:150039330 LATS1 -0.43 -5.97 -0.34 7.5e-9 Lung cancer; CESC cis rs9911578 1.000 rs9901181 chr17:56964271 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.17 0.3 4.64e-7 Intelligence (multi-trait analysis); CESC cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg20476274 chr7:133979776 SLC35B4 0.65 9.4 0.5 2.63e-18 Mean platelet volume; CESC cis rs2055729 0.591 rs6987670 chr8:9883177 C/T cg21625330 chr8:9911636 MSRA -0.5 -6.39 -0.37 7.63e-10 Multiple myeloma (hyperdiploidy); CESC cis rs7508 0.521 rs4377998 chr8:17923339 C/T cg18067069 chr8:17937731 ASAH1 -0.4 -5.71 -0.33 2.95e-8 Atrial fibrillation; CESC cis rs6142102 0.625 rs6142061 chr20:32548335 A/G cg08999081 chr20:33150536 PIGU 0.34 5.1 0.3 6.35e-7 Skin pigmentation; CESC cis rs10751667 1.000 rs12798036 chr11:947585 T/C cg20946044 chr11:1010712 AP2A2 -0.42 -5.68 -0.33 3.61e-8 Alzheimer's disease (late onset); CESC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg14893161 chr1:205819251 PM20D1 0.5 6.76 0.38 8.77e-11 Menarche (age at onset); CESC trans rs11088226 0.645 rs2833904 chr21:33941089 T/C cg09050820 chr6:167586206 TCP10L2 0.82 7.6 0.42 5.16e-13 Gastritis; CESC cis rs4654899 0.833 rs3816454 chr1:21191416 T/G cg05370193 chr1:21551575 ECE1 -0.37 -5.36 -0.31 1.77e-7 Superior frontal gyrus grey matter volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03553080 chr16:88697695 ZC3H18 -0.53 -6.23 -0.36 1.79e-9 Gut microbiome composition (summer); CESC cis rs7949030 0.653 rs2849030 chr11:62366986 G/A cg23462726 chr11:62437636 C11orf83;C11orf48 0.41 5.41 0.32 1.4e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2274273 0.638 rs3825614 chr14:55729387 G/A cg04306507 chr14:55594613 LGALS3 0.3 5.04 0.3 8.61e-7 Protein biomarker; CESC cis rs3820928 0.904 rs4414671 chr2:227816200 T/A cg05526886 chr2:227700861 RHBDD1 -0.44 -5.68 -0.33 3.56e-8 Pulmonary function; CESC cis rs4604732 0.527 rs7546805 chr1:247627259 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.2 0.4 6.34e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg20891558 chr2:74357851 NA 0.82 11.92 0.59 1.58e-26 Gestational age at birth (maternal effect); CESC cis rs11155671 0.530 rs7764376 chr6:150210344 A/G cg09699651 chr6:150184138 LRP11 0.55 7.7 0.43 2.78e-13 Testicular germ cell tumor; CESC cis rs2742234 0.590 rs2505557 chr10:43666016 C/T cg15436174 chr10:43711423 RASGEF1A -0.51 -5.84 -0.34 1.54e-8 Hirschsprung disease; CESC cis rs11122272 0.735 rs2486729 chr1:231535584 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.12 0.35 3.39e-9 Hemoglobin concentration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21167072 chr6:90539455 CASP8AP2 0.45 6.17 0.35 2.55e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9325144 0.554 rs7960616 chr12:39096664 T/A cg26384229 chr12:38710491 ALG10B -0.5 -7.04 -0.4 1.6e-11 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00990635 chr19:19745667 GMIP 0.47 6.15 0.35 2.9e-9 Fibrinogen levels; CESC cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg15485101 chr11:133734466 NA 0.4 6.6 0.38 2.21e-10 Childhood ear infection; CESC cis rs4835473 0.864 rs13145791 chr4:144656841 T/C cg25736465 chr4:144833511 NA -0.33 -5.17 -0.3 4.65e-7 Immature fraction of reticulocytes; CESC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.08 -13.27 -0.63 3.74e-31 Gut microbiome composition (summer); CESC cis rs1355223 0.872 rs7116409 chr11:34751007 T/G cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.12 -0.35 3.3e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2477686 0.526 rs2477690 chr1:2395563 G/A cg02275930 chr1:2372054 NA -0.5 -8.02 -0.44 3.35e-14 Non-obstructive azoospermia; CESC cis rs2731664 0.792 rs335468 chr5:176892349 A/G cg23176889 chr5:176863531 GRK6 0.64 11.34 0.57 1.52e-24 Intelligence (multi-trait analysis); CESC cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg20307385 chr11:47447363 PSMC3 -0.62 -7.61 -0.42 4.69e-13 Subjective well-being; CESC cis rs2832191 0.791 rs7283853 chr21:30498515 G/A cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.5e-20 Dental caries; CESC cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg16386425 chr10:429943 DIP2C -0.57 -7.24 -0.41 4.97e-12 Psychosis in Alzheimer's disease; CESC cis rs35955747 0.777 rs5997895 chr22:31566173 T/G cg25791279 chr22:32026902 PISD -0.42 -5.1 -0.3 6.35e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs10129255 0.500 rs6576229 chr14:107186773 G/A cg23076370 chr14:107095027 NA -0.66 -10.03 -0.52 2.9e-20 Kawasaki disease; CESC cis rs9430161 0.579 rs7542158 chr1:11040193 G/A cg27631724 chr1:11040367 C1orf127 0.44 7.63 0.42 4.18e-13 Ewing sarcoma; CESC cis rs72781680 0.898 rs72780111 chr2:23991146 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs6580649 0.843 rs3803184 chr12:48398002 G/C cg05342945 chr12:48394962 COL2A1 -0.55 -6.61 -0.38 2.16e-10 Lung cancer; CESC trans rs61931739 0.500 rs56404399 chr12:34543101 A/G cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC cis rs1153858 1.000 rs11858495 chr15:45637662 A/G cg21132104 chr15:45694354 SPATA5L1 -0.75 -9.34 -0.5 4.19e-18 Homoarginine levels; CESC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg24250549 chr1:154909240 PMVK 0.64 9.28 0.5 6.44e-18 Prostate cancer; CESC cis rs72901758 0.768 rs76962230 chr17:76251920 A/G cg26068271 chr17:76253126 NA 0.46 6.47 0.37 4.69e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs10927875 0.619 rs12121764 chr1:16138059 A/T cg21385522 chr1:16154831 NA -0.75 -10.77 -0.55 1.16e-22 Dilated cardiomyopathy; CESC cis rs12145833 0.538 rs4658547 chr1:243391131 T/G cg02356786 chr1:243265016 LOC731275 -0.79 -6.57 -0.37 2.71e-10 Obesity (early onset extreme); CESC cis rs4664304 0.710 rs9636280 chr2:160717852 C/T cg03641300 chr2:160917029 PLA2R1 -0.42 -5.57 -0.32 6.19e-8 Crohn's disease;Inflammatory bowel disease; CESC trans rs10242455 0.557 rs59672032 chr7:99058697 T/C cg09045935 chr12:6379348 NA 0.9 7.78 0.43 1.67e-13 Blood metabolite levels; CESC cis rs9303401 0.538 rs8078280 chr17:56473132 A/G cg12560992 chr17:57184187 TRIM37 0.51 5.17 0.3 4.71e-7 Cognitive test performance; CESC cis rs2073499 0.872 rs41291724 chr3:50294066 C/G cg05260129 chr3:50388622 TUSC4;CYB561D2 0.72 5.88 0.34 1.21e-8 Schizophrenia; CESC cis rs7264396 0.508 rs6060739 chr20:34567592 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.7 -8.91 -0.48 8.56e-17 Total cholesterol levels; CESC cis rs1018836 0.828 rs2105968 chr8:91591825 A/G cg16814680 chr8:91681699 NA -0.68 -9.99 -0.52 3.84e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg03188948 chr7:1209495 NA 0.73 7.02 0.4 1.85e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10556830 chr5:68462986 CCNB1 -0.42 -6.06 -0.35 4.55e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00004979 chr12:111885466 SH2B3 -0.5 -6.23 -0.36 1.79e-9 Gut microbiome composition (summer); CESC cis rs7940866 0.874 rs10894306 chr11:130873882 A/C cg12179176 chr11:130786555 SNX19 0.68 9.96 0.52 4.78e-20 Schizophrenia; CESC cis rs360798 0.512 rs2430388 chr2:63106784 T/C cg17519650 chr2:63277830 OTX1 0.55 7.07 0.4 1.39e-11 Coronary artery disease; CESC cis rs155076 0.702 rs482731 chr13:21846075 G/A cg11317459 chr13:21872234 NA -1.04 -11.45 -0.58 6.22e-25 White matter hyperintensity burden; CESC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 10.1 0.53 1.68e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19321730 chr11:63996766 NUDT22;DNAJC4 0.47 6.66 0.38 1.55e-10 Fibrinogen levels; CESC cis rs2180341 1.000 rs9398837 chr6:127635217 G/A cg27446573 chr6:127587934 RNF146 1.09 16.38 0.71 3.79e-42 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12588476 chr7:99647494 ZSCAN21 -0.5 -6.43 -0.37 5.85e-10 Ulcerative colitis; CESC cis rs1832871 0.672 rs62437399 chr6:158784251 C/A cg07165851 chr6:158734300 TULP4 0.56 5.49 0.32 9.27e-8 Height; CESC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs7512552 0.809 rs9436108 chr1:150360930 A/G cg15654264 chr1:150340011 RPRD2 0.4 5.28 0.31 2.65e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC trans rs6951245 0.706 rs1133116 chr7:1195215 A/C cg13565492 chr6:43139072 SRF -0.59 -6.09 -0.35 4.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1062177 0.855 rs1346489 chr5:151266534 C/T cg00977110 chr5:151150581 G3BP1 0.54 6.22 0.36 1.89e-9 Preschool internalizing problems; CESC cis rs4474465 0.850 rs4441045 chr11:78220436 G/T cg27205649 chr11:78285834 NARS2 0.44 5.27 0.31 2.83e-7 Alzheimer's disease (survival time); CESC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg04315214 chr1:2043799 PRKCZ 0.54 9.38 0.5 3.02e-18 Height; CESC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22918914 chr5:6378597 MED10 -0.51 -6.22 -0.36 1.93e-9 Gut microbiome composition (summer); CESC cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.13 0.3 5.57e-7 Personality dimensions; CESC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg08392591 chr16:89556376 ANKRD11 0.6 8.15 0.45 1.47e-14 Multiple myeloma (IgH translocation); CESC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg18337363 chr3:52569053 NT5DC2 0.3 5.57 0.32 6.28e-8 Electroencephalogram traits; CESC cis rs35160687 0.644 rs57270703 chr2:86516873 T/C cg01119172 chr2:86362222 SNORD94;PTCD3 -0.38 -5.1 -0.3 6.57e-7 Night sleep phenotypes; CESC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.39 -0.37 7.41e-10 Depression; CESC cis rs7705819 1.000 rs6887996 chr5:172870964 A/T cg14746387 chr5:172879299 NA 0.37 5.07 0.3 7.44e-7 Stroke; CESC trans rs1814175 0.765 rs1722003 chr11:49895896 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -20.88 -0.79 6.44e-58 Height; CESC cis rs4906332 1.000 rs8012127 chr14:103942762 G/A cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.49e-10 Coronary artery disease; CESC cis rs10883723 0.810 rs7092622 chr10:104249919 T/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.1 0.3 6.33e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg24549020 chr5:56110836 MAP3K1 0.47 5.82 0.34 1.66e-8 Initial pursuit acceleration; CESC cis rs1707322 0.827 rs12125508 chr1:46246010 A/G cg06784218 chr1:46089804 CCDC17 0.36 6.14 0.35 3e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17826219 0.500 rs57005940 chr17:29066329 C/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Body mass index; CESC cis rs7959452 0.640 rs4761233 chr12:69722880 T/C cg22834771 chr12:69754056 YEATS4 -0.39 -5.07 -0.3 7.31e-7 Blood protein levels; CESC cis rs2191566 0.960 rs367209 chr19:44506249 A/G cg20607764 chr19:44506953 ZNF230 0.6 7.98 0.44 4.5e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs425277 1.000 rs262670 chr1:2082458 C/T cg04315214 chr1:2043799 PRKCZ -0.38 -5.3 -0.31 2.42e-7 Height; CESC cis rs854765 0.647 rs7212447 chr17:17987067 G/A cg16928487 chr17:17741425 SREBF1 -0.53 -8.68 -0.47 4.24e-16 Total body bone mineral density; CESC cis rs12545109 0.800 rs2670028 chr8:57423673 G/A cg09654669 chr8:57350985 NA -0.45 -5.84 -0.34 1.5e-8 Obesity-related traits; CESC cis rs8077889 0.700 rs28571770 chr17:41904066 A/T cg26893861 chr17:41843967 DUSP3 0.74 9.39 0.5 2.82e-18 Triglycerides; CESC cis rs6866344 0.697 rs17184344 chr5:178129281 A/G cg10224037 chr5:178157518 ZNF354A 0.69 7.75 0.43 1.96e-13 Neutrophil percentage of white cells; CESC cis rs9467711 0.606 rs12174639 chr6:26373121 G/A cg12826209 chr6:26865740 GUSBL1 0.62 5.31 0.31 2.31e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9868809 0.772 rs12107252 chr3:48691316 T/C cg07636037 chr3:49044803 WDR6 -0.72 -6.6 -0.38 2.26e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs4523957 0.614 rs2316512 chr17:2064710 A/T cg16513277 chr17:2031491 SMG6 -0.72 -10.2 -0.53 8.12e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1448094 0.791 rs10863124 chr12:86352548 A/T cg02569458 chr12:86230093 RASSF9 0.4 5.99 0.35 6.8e-9 Major depressive disorder; CESC cis rs11048434 0.698 rs10842537 chr12:9066158 T/C cg23795048 chr12:9217529 LOC144571 0.36 5.71 0.33 2.99e-8 Sjögren's syndrome; CESC cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg10523679 chr1:76189770 ACADM -0.58 -6.24 -0.36 1.73e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg06873352 chr17:61820015 STRADA -0.73 -12.95 -0.62 4.86e-30 Prudent dietary pattern; CESC cis rs7959452 1.000 rs2168029 chr12:69734641 A/C cg22834771 chr12:69754056 YEATS4 -0.43 -5.59 -0.32 5.53e-8 Blood protein levels; CESC cis rs7223966 1.000 rs11079508 chr17:61750066 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.16 -0.3 4.73e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs5758659 0.652 rs133349 chr22:42428727 A/T cg04733989 chr22:42467013 NAGA 0.47 6.62 0.38 2e-10 Cognitive function; CESC cis rs4523957 0.928 rs422632 chr17:2162049 G/A cg16513277 chr17:2031491 SMG6 0.6 8.18 0.45 1.22e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7918232 0.882 rs788237 chr10:27457932 C/T cg14442939 chr10:27389572 ANKRD26 -0.67 -6.43 -0.37 5.92e-10 Breast cancer; CESC cis rs6088590 0.561 rs6059918 chr20:33150503 C/T cg08999081 chr20:33150536 PIGU 0.69 12.05 0.59 5.92e-27 Coronary artery disease; CESC cis rs9916302 0.861 rs4795376 chr17:37669043 T/C cg20243544 chr17:37824526 PNMT 0.48 6.1 0.35 3.71e-9 Glomerular filtration rate (creatinine); CESC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg25427524 chr10:38739819 LOC399744 -0.7 -10.24 -0.53 6.01e-21 Extrinsic epigenetic age acceleration; CESC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg24562669 chr7:97807699 LMTK2 0.48 7.08 0.4 1.31e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs27434 0.510 rs27038 chr5:96112954 A/G cg16492584 chr5:96139282 ERAP1 -0.48 -5.84 -0.34 1.52e-8 Ankylosing spondylitis; CESC cis rs7631605 0.905 rs7649344 chr3:37006396 C/T cg22985146 chr3:37219077 LRRFIP2 0.35 5.43 0.32 1.27e-7 Cerebrospinal P-tau181p levels; CESC cis rs8005677 1.000 rs4981446 chr14:23381413 A/G cg01529538 chr14:23388837 RBM23 0.51 6.87 0.39 4.64e-11 Cognitive ability (multi-trait analysis); CESC cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg18230493 chr5:56204884 C5orf35 -0.71 -8.21 -0.45 9.61e-15 Initial pursuit acceleration; CESC cis rs2708240 0.539 rs2538994 chr7:147574509 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.42 -6.36 -0.36 8.59e-10 QT interval (drug interaction); CESC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg05064044 chr6:292385 DUSP22 -0.69 -8.96 -0.48 6.05e-17 Menopause (age at onset); CESC cis rs3820928 0.692 rs17416354 chr2:227770844 A/G cg05526886 chr2:227700861 RHBDD1 -0.56 -7.4 -0.41 1.85e-12 Pulmonary function; CESC cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4835473 0.932 rs1973608 chr4:144834210 A/C cg25736465 chr4:144833511 NA 0.42 6.4 0.37 6.94e-10 Immature fraction of reticulocytes; CESC cis rs12142240 0.698 rs10158130 chr1:46822600 T/C cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs6964587 0.967 rs34344935 chr7:91835436 G/A cg17063962 chr7:91808500 NA 0.58 7.81 0.43 1.35e-13 Breast cancer; CESC cis rs77861329 0.925 rs72964042 chr3:52088485 A/C cg08692210 chr3:52188851 WDR51A 0.81 7.23 0.41 5.25e-12 Macrophage inflammatory protein 1b levels; CESC cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg22903471 chr2:27725779 GCKR -0.56 -7.71 -0.43 2.59e-13 Total body bone mineral density; CESC cis rs2439831 1.000 rs690263 chr15:43704465 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.87 10.58 0.55 4.62e-22 Lung cancer in ever smokers; CESC cis rs17376456 0.825 rs6874766 chr5:93213807 C/G cg21475434 chr5:93447410 FAM172A -0.83 -7.09 -0.4 1.2e-11 Diabetic retinopathy; CESC trans rs35110281 0.591 rs230642 chr21:44915533 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.5 -7.08 -0.4 1.29e-11 Mean corpuscular volume; CESC cis rs8067354 0.645 rs2173120 chr17:57892640 A/T cg13753209 chr17:57696993 CLTC 0.56 6.3 0.36 1.21e-9 Hemoglobin concentration; CESC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg06808227 chr14:105710500 BRF1 -0.61 -7.38 -0.41 2.01e-12 Mean platelet volume;Platelet distribution width; CESC cis rs6690583 0.623 rs893618 chr1:85513770 C/T cg22153463 chr1:85462885 MCOLN2 0.74 7.68 0.43 3.05e-13 Serum sulfate level; CESC cis rs9611565 0.559 rs5758412 chr22:42080803 T/A cg17376030 chr22:41985996 PMM1 -0.79 -8.55 -0.47 9.65e-16 Vitiligo; CESC cis rs6500395 1.000 rs1872654 chr16:48671050 C/T cg04672837 chr16:48644449 N4BP1 0.51 6.43 0.37 6.06e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.53 -6.69 -0.38 1.33e-10 Prudent dietary pattern; CESC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg00106254 chr7:1943704 MAD1L1 -0.5 -6.22 -0.36 1.88e-9 Bipolar disorder and schizophrenia; CESC cis rs36051895 0.626 rs9695934 chr9:5153108 C/G cg02405213 chr9:5042618 JAK2 -0.54 -6.88 -0.39 4.4e-11 Pediatric autoimmune diseases; CESC cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg23711669 chr6:146136114 FBXO30 -0.92 -12.44 -0.61 2.84e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs4642101 0.512 rs9813960 chr3:12818205 A/G cg24848339 chr3:12840334 CAND2 0.43 6.96 0.39 2.7e-11 QRS complex (12-leadsum); CESC cis rs7818688 0.653 rs11786088 chr8:95836140 C/T cg16049864 chr8:95962084 TP53INP1 0.54 5.7 0.33 3.15e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg18099408 chr3:52552593 STAB1 -0.33 -5.34 -0.31 2.02e-7 Bipolar disorder; CESC trans rs561341 1.000 rs537166 chr17:30326827 C/T cg20587970 chr11:113659929 NA -1.13 -14.25 -0.66 1.39e-34 Hip circumference adjusted for BMI; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg21941105 chr19:10491405 TYK2 0.47 6.14 0.35 3.08e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18483322 chr2:97523826 ANKRD39 0.42 6.0 0.35 6.6e-9 Gut microbiota (bacterial taxa); CESC cis rs7044106 0.762 rs10760115 chr9:123476952 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.0 0.62 3.26e-30 Hip circumference adjusted for BMI; CESC cis rs761746 0.921 rs12171042 chr22:32011225 T/C cg25791279 chr22:32026902 PISD 0.57 6.67 0.38 1.49e-10 Intelligence; CESC cis rs5753618 0.583 rs5753631 chr22:31863022 A/C cg02404636 chr22:31891804 SFI1 0.39 5.29 0.31 2.59e-7 Colorectal cancer; CESC cis rs3796352 1.000 rs11714876 chr3:53101640 C/G cg12962167 chr3:53033115 SFMBT1 -0.62 -5.65 -0.33 4.09e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs61931739 0.500 rs12146843 chr12:34451738 T/G cg23762105 chr12:34175262 ALG10 -0.4 -5.22 -0.31 3.7e-7 Morning vs. evening chronotype; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02837703 chr11:67236413 TMEM134 -0.45 -6.13 -0.35 3.22e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4835473 0.932 rs28668841 chr4:144903683 A/T cg25736465 chr4:144833511 NA -0.43 -6.49 -0.37 4.21e-10 Immature fraction of reticulocytes; CESC cis rs208520 1.000 rs12192261 chr6:66985268 A/G cg07460842 chr6:66804631 NA 0.87 10.14 0.53 1.25e-20 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25075503 chr6:89673509 RNGTT 0.52 6.01 0.35 5.96e-9 Gut microbiome composition (summer); CESC cis rs6831352 0.918 rs13127153 chr4:100058121 C/T cg13256891 chr4:100009986 ADH5 -0.77 -8.49 -0.46 1.5e-15 Alcohol dependence; CESC cis rs644799 0.610 rs1255179 chr11:95472097 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.43 5.98 0.34 7.37e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg22638593 chr5:131593259 PDLIM4 0.4 5.04 0.3 8.6e-7 Breast cancer; CESC cis rs7618501 0.933 rs6809431 chr3:49804119 A/G cg24308560 chr3:49941425 MST1R -0.52 -7.18 -0.4 7.15e-12 Intelligence (multi-trait analysis); CESC cis rs7605827 0.930 rs4668921 chr2:15672071 T/C cg19274914 chr2:15703543 NA 0.39 6.93 0.39 3.15e-11 Educational attainment (years of education); CESC cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg19748678 chr4:122722346 EXOSC9 0.79 10.03 0.52 2.85e-20 Type 2 diabetes; CESC cis rs595982 0.559 rs17206714 chr19:49362001 T/A cg15549821 chr19:49342101 PLEKHA4 -0.69 -7.74 -0.43 2.11e-13 Red cell distribution width; CESC cis rs2576037 0.796 rs2576043 chr18:44573476 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.6 -8.52 -0.46 1.19e-15 Personality dimensions; CESC cis rs9659323 0.539 rs1750331 chr1:119494973 A/G cg05756136 chr1:119680316 WARS2 -0.45 -6.17 -0.35 2.56e-9 Body mass index; CESC cis rs863345 0.836 rs10908652 chr1:158453924 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -5.97 -0.34 7.47e-9 Pneumococcal bacteremia; CESC cis rs9858542 1.000 rs9882740 chr3:49702484 T/C cg03060546 chr3:49711283 APEH -0.57 -6.8 -0.39 7.07e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9549260 0.755 rs17061503 chr13:41246758 A/G cg21288729 chr13:41239152 FOXO1 -0.67 -8.27 -0.45 6.49e-15 Red blood cell count; CESC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg23708337 chr7:1209742 NA 0.55 5.42 0.32 1.33e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.765 rs202659 chr22:41811620 T/C cg17376030 chr22:41985996 PMM1 -0.59 -6.24 -0.36 1.69e-9 Vitiligo; CESC cis rs704 0.605 rs2227736 chr17:26693231 G/C cg10494684 chr17:26645200 TMEM97 -0.38 -5.32 -0.31 2.25e-7 Osteoprotegerin levels; CESC cis rs722599 0.639 rs2193596 chr14:75234101 A/C cg11812906 chr14:75593930 NEK9 0.45 5.17 0.3 4.52e-7 IgG glycosylation; CESC cis rs137699 1.000 rs2049986 chr22:39756854 C/G cg24399712 chr22:39784796 NA 0.39 5.29 0.31 2.54e-7 IgG glycosylation; CESC cis rs2274273 0.840 rs7153110 chr14:55820628 A/G cg04306507 chr14:55594613 LGALS3 0.32 6.26 0.36 1.58e-9 Protein biomarker; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg24862861 chr10:976594 NA -0.45 -6.01 -0.35 6.23e-9 Height; CESC cis rs4808199 0.947 rs2099333 chr19:19605963 C/T cg03709012 chr19:19516395 GATAD2A 1.15 13.01 0.62 3.04e-30 Nonalcoholic fatty liver disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05898482 chr7:152373203 XRCC2 -0.46 -6.24 -0.36 1.72e-9 Asthma; CESC cis rs2777491 0.957 rs316614 chr15:41746625 A/G cg20272979 chr15:41787780 ITPKA 0.44 6.5 0.37 4.02e-10 Ulcerative colitis; CESC cis rs3806843 0.676 rs2245643 chr5:140029780 C/T cg26395211 chr5:140044315 WDR55 0.52 6.81 0.39 6.4e-11 Depressive symptoms (multi-trait analysis); CESC cis rs2276314 0.857 rs62101394 chr18:33592299 C/T cg19628046 chr18:33552617 C18orf21 0.51 5.76 0.33 2.3e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs72634258 0.786 rs9434991 chr1:8178708 G/C cg00042356 chr1:8021962 PARK7 0.5 5.39 0.31 1.55e-7 Inflammatory bowel disease; CESC cis rs60843830 1.000 rs55946380 chr2:268293 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.78 10.02 0.52 2.91e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs17023223 0.537 rs66715579 chr1:119725432 G/A cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs17666538 0.535 rs168062 chr8:632444 T/A cg07234876 chr8:600039 NA 0.8 5.98 0.34 7.33e-9 IgG glycosylation; CESC cis rs17253792 0.915 rs28375514 chr14:56179941 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.73 5.13 0.3 5.7e-7 Putamen volume; CESC cis rs9581857 0.579 rs75326986 chr13:27997758 C/T cg01674679 chr13:27998804 GTF3A -0.66 -5.49 -0.32 9.61e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs2204008 0.837 rs11168504 chr12:37964922 G/T cg13010199 chr12:38710504 ALG10B 0.52 6.51 0.37 3.74e-10 Bladder cancer; CESC cis rs2479724 1.000 rs2479724 chr6:41890982 T/C cg08135965 chr6:41755394 TOMM6 0.37 5.07 0.3 7.6e-7 Menarche (age at onset); CESC cis rs2243480 1.000 rs2465120 chr7:65620974 C/G cg13147721 chr7:65941812 NA -0.97 -9.19 -0.49 1.2e-17 Diabetic kidney disease; CESC cis rs7572263 0.724 rs12986551 chr2:209052303 T/C cg23998903 chr2:209048830 C2orf80 -0.39 -5.14 -0.3 5.4e-7 Glioma;Non-glioblastoma glioma; CESC cis rs10857712 0.904 rs7918164 chr10:135223323 G/A cg01444801 chr10:135216882 MTG1 -0.47 -5.67 -0.33 3.75e-8 Systemic lupus erythematosus; CESC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg05368731 chr17:41323189 NBR1 0.76 10.52 0.54 7.29e-22 Menopause (age at onset); CESC cis rs7100689 0.577 rs2236569 chr10:82043576 G/A cg09936400 chr10:82049201 MAT1A 0.4 6.16 0.35 2.72e-9 Post bronchodilator FEV1; CESC cis rs1348850 0.567 rs880899 chr2:178532416 A/G cg23306229 chr2:178417860 TTC30B 0.54 7.16 0.4 8.11e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg17376030 chr22:41985996 PMM1 0.77 8.3 0.45 5.53e-15 Vitiligo; CESC cis rs11098499 0.697 rs11941899 chr4:120382758 C/A cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.05e-8 Corneal astigmatism; CESC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg26314531 chr2:26401878 FAM59B -0.44 -5.06 -0.3 7.91e-7 Gut microbiome composition (summer); CESC cis rs897080 0.552 rs1067392 chr2:44639097 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 5.97 0.34 7.74e-9 Height; CESC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg07092213 chr7:1199455 ZFAND2A -0.5 -5.18 -0.3 4.36e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg27266027 chr21:40555129 PSMG1 0.48 5.71 0.33 2.99e-8 Cognitive function; CESC cis rs2073300 0.609 rs6137919 chr20:23363163 T/C cg12062639 chr20:23401060 NAPB 1.08 8.67 0.47 4.32e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2777491 0.957 rs3743038 chr15:41694743 C/T cg02330683 chr15:41787940 ITPKA 0.48 7.1 0.4 1.14e-11 Ulcerative colitis; CESC trans rs722599 0.748 rs2300599 chr14:75359441 A/G cg00095594 chr1:236228625 NID1 -0.39 -6.01 -0.35 6.01e-9 IgG glycosylation; CESC cis rs9894429 0.966 rs10871499 chr17:79589006 G/A cg18240062 chr17:79603768 NPLOC4 0.73 10.36 0.54 2.38e-21 Eye color traits; CESC cis rs7267979 1.000 rs2500418 chr20:25382268 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -15.95 -0.7 1.31e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg05585544 chr11:47624801 NA -0.52 -8.03 -0.44 3.23e-14 Subjective well-being; CESC cis rs9549260 0.755 rs12585875 chr13:41199531 A/G cg21288729 chr13:41239152 FOXO1 0.64 8.26 0.45 7.14e-15 Red blood cell count; CESC cis rs4924935 0.851 rs966811 chr17:18830287 G/A cg26378065 chr17:18585709 ZNF286B -0.47 -5.3 -0.31 2.39e-7 Pancreatic cancer; CESC cis rs25645 0.800 rs11078935 chr17:38192137 T/G cg17467752 chr17:38218738 THRA -0.55 -7.09 -0.4 1.24e-11 Myeloid white cell count; CESC cis rs870825 0.616 rs2090590 chr4:185647850 A/C cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs9487051 0.676 rs9400268 chr6:109600550 C/T cg21918786 chr6:109611834 NA -0.39 -5.74 -0.33 2.55e-8 Reticulocyte fraction of red cells; CESC cis rs1003719 0.646 rs2835672 chr21:38581234 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.22 -0.45 8.86e-15 Eye color traits; CESC cis rs910316 0.737 rs424120 chr14:75482828 G/T cg08847533 chr14:75593920 NEK9 -0.9 -15.43 -0.69 9.04e-39 Height; CESC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg19163074 chr7:65112434 INTS4L2 -0.46 -5.18 -0.3 4.47e-7 Aortic root size; CESC cis rs6570726 0.791 rs1509213 chr6:145783360 G/A cg05347473 chr6:146136440 FBXO30 -0.55 -7.13 -0.4 9.41e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg09658497 chr7:2847517 GNA12 -0.38 -5.37 -0.31 1.72e-7 Height; CESC cis rs9399401 0.710 rs12190271 chr6:142681409 A/G cg03128060 chr6:142623767 GPR126 -0.4 -6.87 -0.39 4.55e-11 Chronic obstructive pulmonary disease; CESC cis rs10791323 0.517 rs1120247 chr11:133745180 T/G cg15485101 chr11:133734466 NA 0.3 5.13 0.3 5.52e-7 Childhood ear infection; CESC cis rs904092 0.720 rs1230028 chr4:100182886 C/G cg12011299 chr4:100065546 ADH4 0.53 6.11 0.35 3.48e-9 Alcohol dependence; CESC cis rs17666538 0.585 rs336437 chr8:636251 A/C cg23958373 chr8:599963 NA 0.81 6.15 0.35 2.91e-9 IgG glycosylation; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg24228800 chr13:113863762 CUL4A;PCID2 -0.46 -6.08 -0.35 4.14e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg04518342 chr5:131593106 PDLIM4 0.4 5.94 0.34 8.79e-9 Breast cancer; CESC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg22823121 chr1:150693482 HORMAD1 0.45 6.24 0.36 1.76e-9 Urate levels; CESC cis rs7582720 1.000 rs72926796 chr2:203827480 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg13114125 chr14:105738426 BRF1 -0.88 -10.73 -0.55 1.49e-22 Mean platelet volume;Platelet distribution width; CESC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs6831352 0.840 rs17817868 chr4:100060623 C/T cg13256891 chr4:100009986 ADH5 -0.75 -8.21 -0.45 9.89e-15 Alcohol dependence; CESC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg18305652 chr10:134549665 INPP5A 0.47 6.64 0.38 1.79e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -6.26 -0.36 1.56e-9 Developmental language disorder (linguistic errors); CESC cis rs116095464 0.558 rs2288459 chr5:231143 T/C cg22857025 chr5:266934 NA -1.28 -18.2 -0.75 1.47e-48 Breast cancer; CESC trans rs10411161 0.702 rs11879336 chr19:52389627 C/T cg22319618 chr22:45562946 NUP50 -0.79 -7.76 -0.43 1.81e-13 Breast cancer; CESC cis rs4595586 0.525 rs7972595 chr12:39338000 G/A cg26384229 chr12:38710491 ALG10B 0.64 9.0 0.48 4.59e-17 Morning vs. evening chronotype; CESC cis rs12474201 0.963 rs3829835 chr2:46925789 C/T cg06386533 chr2:46925753 SOCS5 0.92 12.79 0.62 1.66e-29 Height; CESC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg08859206 chr1:53392774 SCP2 -0.68 -9.87 -0.52 9.2e-20 Monocyte count; CESC cis rs13385 0.769 rs7727069 chr5:139573265 A/G cg26211634 chr5:139558579 C5orf32 0.47 5.28 0.31 2.75e-7 Atrial fibrillation; CESC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg04287289 chr16:89883240 FANCA 0.87 14.3 0.66 8.95e-35 Vitiligo; CESC cis rs11252926 0.537 rs61836851 chr10:447231 T/C cg16386425 chr10:429943 DIP2C -0.56 -7.23 -0.41 5.02e-12 Psychosis in Alzheimer's disease; CESC cis rs9341808 0.500 rs2322629 chr6:80811540 C/T cg08355045 chr6:80787529 NA 0.37 5.51 0.32 8.3e-8 Sitting height ratio; CESC cis rs1348850 0.526 rs935426 chr2:178369433 T/C cg23306229 chr2:178417860 TTC30B 0.8 7.39 0.41 1.96e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9399135 0.967 rs4896122 chr6:135295081 T/C cg22676075 chr6:135203613 NA 0.52 7.21 0.4 5.94e-12 Red blood cell count; CESC trans rs1814175 0.817 rs1615305 chr11:49895222 T/A cg15704280 chr7:45808275 SEPT13 -1.03 -20.9 -0.79 5.71e-58 Height; CESC cis rs3857067 0.806 rs4693002 chr4:95115302 A/G cg11021082 chr4:95130006 SMARCAD1 -0.58 -8.57 -0.47 8.86e-16 QT interval; CESC cis rs7762018 1.000 rs4716378 chr6:170086568 G/C cg13891659 chr6:170190454 C6orf122;C6orf208 0.53 5.52 0.32 8.28e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7078219 0.505 rs4129132 chr10:101284637 T/G cg09788492 chr10:101292477 NKX2-3 0.33 6.35 0.36 9.52e-10 Dental caries; CESC cis rs4654899 0.802 rs17416732 chr1:21256368 T/C cg05370193 chr1:21551575 ECE1 0.38 5.51 0.32 8.58e-8 Superior frontal gyrus grey matter volume; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg10579840 chr8:99306110 NIPAL2 -0.48 -6.24 -0.36 1.69e-9 Height; CESC cis rs977987 0.806 rs17696696 chr16:75393352 G/T cg03315344 chr16:75512273 CHST6 -0.4 -5.67 -0.33 3.65e-8 Dupuytren's disease; CESC cis rs3096299 0.933 rs2965938 chr16:89491336 C/T cg02187348 chr16:89574699 SPG7 0.59 8.01 0.44 3.73e-14 Multiple myeloma (IgH translocation); CESC cis rs6942756 1.000 rs6971917 chr7:128976919 G/A cg02491457 chr7:128862824 NA -0.68 -9.24 -0.49 8.31e-18 White matter hyperintensity burden; CESC cis rs644799 0.544 rs1727165 chr11:95521648 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.49 6.47 0.37 4.68e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs9354308 0.899 rs2802056 chr6:66546219 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 6.62 0.38 1.93e-10 Metabolite levels; CESC cis rs72829446 0.530 rs11869899 chr17:7407915 C/T cg02795151 chr17:7402630 POLR2A 0.61 6.59 0.38 2.32e-10 Androgen levels; CESC cis rs2857078 0.720 rs9901595 chr17:42305699 G/A cg09913183 chr17:42254507 C17orf65;ASB16 0.41 5.1 0.3 6.35e-7 Red cell distribution width;Reticulocyte count; CESC cis rs5760092 0.618 rs4461358 chr22:24260106 T/C cg24846343 chr22:24311635 DDTL -0.45 -6.39 -0.37 7.51e-10 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs8092503 1.000 rs3764513 chr18:52495089 A/G cg12377874 chr18:52495404 RAB27B 0.37 6.14 0.35 3.02e-9 Childhood body mass index; CESC cis rs11864453 0.826 rs2240243 chr16:72137561 A/G cg16558253 chr16:72132732 DHX38 0.63 9.99 0.52 3.84e-20 Fibrinogen levels; CESC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.56 -5.93 -0.34 9.34e-9 Schizophrenia; CESC trans rs1814175 0.935 rs10839317 chr11:49657228 A/C cg15704280 chr7:45808275 SEPT13 -1.01 -17.87 -0.74 2.03e-47 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11939075 chr4:83956728 COPS4 -0.61 -6.82 -0.39 6.29e-11 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs457287 0.772 rs691772 chr9:4825117 C/T cg20099147 chr19:56652066 ZNF444 0.5 6.05 0.35 5.04e-9 Platelet count; CESC cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg23711669 chr6:146136114 FBXO30 1.0 15.28 0.68 3.05e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs6831352 0.819 rs13832 chr4:99993075 C/A cg12011299 chr4:100065546 ADH4 0.68 8.5 0.46 1.35e-15 Alcohol dependence; CESC trans rs9467711 0.659 rs35680819 chr6:26455814 T/C cg01620082 chr3:125678407 NA -0.81 -6.27 -0.36 1.44e-9 Autism spectrum disorder or schizophrenia; CESC cis rs6088813 1.000 rs6087703 chr20:33996433 T/C cg14752227 chr20:34000481 UQCC -0.4 -5.08 -0.3 7.17e-7 Height; CESC cis rs6088580 0.634 rs4258875 chr20:32924895 C/A cg08999081 chr20:33150536 PIGU -0.64 -11.02 -0.56 1.75e-23 Glomerular filtration rate (creatinine); CESC cis rs1784581 0.569 rs9365357 chr6:162414913 A/G cg17173639 chr6:162384350 PARK2 0.58 8.71 0.47 3.3e-16 Itch intensity from mosquito bite; CESC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 10.69 0.55 2.05e-22 Alzheimer's disease; CESC cis rs5760092 0.755 rs4585126 chr22:24270005 T/C cg09033563 chr22:24373618 LOC391322 0.45 5.53 0.32 7.63e-8 Urinary 1,3-butadiene metabolite levels in smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20545551 chr22:18560636 PEX26 0.68 7.37 0.41 2.24e-12 Gut microbiome composition (summer); CESC cis rs11683229 0.704 rs13027462 chr2:63154816 A/G cg17519650 chr2:63277830 OTX1 -0.66 -5.47 -0.32 1.04e-7 Protein quantitative trait loci; CESC cis rs9815354 0.812 rs73071330 chr3:41810553 T/G cg03022575 chr3:42003672 ULK4 0.68 6.06 0.35 4.7e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs67311347 0.955 rs6773383 chr3:40377412 A/T cg09455208 chr3:40491958 NA 0.45 7.9 0.44 7.28e-14 Renal cell carcinoma; CESC trans rs9951602 0.512 rs8085719 chr18:76649111 A/G cg02800362 chr5:177631904 HNRNPAB 0.65 8.62 0.47 6.15e-16 Obesity-related traits; CESC cis rs881375 0.967 rs10733648 chr9:123700779 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.38 5.05 0.3 8.12e-7 Rheumatoid arthritis; CESC cis rs7116495 0.609 rs73543612 chr11:71820350 C/T cg26138937 chr11:71823887 C11orf51 1.29 7.98 0.44 4.34e-14 Severe influenza A (H1N1) infection; CESC cis rs9487051 0.698 rs4301336 chr6:109650140 A/T cg01475377 chr6:109611718 NA 0.39 5.29 0.31 2.5e-7 Reticulocyte fraction of red cells; CESC cis rs8018808 0.935 rs7146595 chr14:77932017 A/C cg20045696 chr14:77926864 AHSA1 0.43 5.9 0.34 1.13e-8 Myeloid white cell count; CESC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg03351412 chr1:154909251 PMVK 0.51 6.1 0.35 3.81e-9 Prostate cancer; CESC cis rs2130392 0.926 rs7679215 chr4:185635311 C/T cg21366198 chr4:185655624 MLF1IP 0.46 6.55 0.37 3.01e-10 Kawasaki disease; CESC trans rs61931739 0.500 rs11836198 chr12:34552782 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.39 0.41 1.9e-12 Morning vs. evening chronotype; CESC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg21782813 chr7:2030301 MAD1L1 0.41 5.72 0.33 2.9e-8 Bipolar disorder and schizophrenia; CESC cis rs9790314 0.905 rs1154701 chr3:161008025 T/A cg03342759 chr3:160939853 NMD3 -0.46 -6.12 -0.35 3.41e-9 Morning vs. evening chronotype; CESC cis rs13095912 0.752 rs13092283 chr3:185338005 T/C cg11274856 chr3:185301563 NA 0.37 5.51 0.32 8.61e-8 Systolic blood pressure; CESC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.08e-10 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19419581 chr17:79482410 NA -0.47 -6.68 -0.38 1.36e-10 Gambling; CESC cis rs9399401 0.626 rs3817928 chr6:142750516 A/G cg04461802 chr6:142623433 GPR126 0.39 5.69 0.33 3.29e-8 Chronic obstructive pulmonary disease; CESC cis rs4730250 0.708 rs74983157 chr7:106823951 A/G cg02696742 chr7:106810147 HBP1 -0.53 -5.07 -0.3 7.37e-7 Osteoarthritis; CESC cis rs894734 0.567 rs7138907 chr12:54324576 C/T cg12374095 chr12:54320830 NA -0.42 -5.93 -0.34 9.48e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CESC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg12963246 chr6:28129442 ZNF389 0.59 7.68 0.43 3e-13 Depression; CESC cis rs7107174 0.901 rs10899500 chr11:78125246 A/G cg02023728 chr11:77925099 USP35 0.45 5.83 0.34 1.58e-8 Testicular germ cell tumor; CESC cis rs1018836 0.699 rs13271657 chr8:91474599 C/G cg16814680 chr8:91681699 NA -0.54 -7.09 -0.4 1.2e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs10751667 0.643 rs7394524 chr11:933865 T/C cg20946044 chr11:1010712 AP2A2 -0.4 -5.43 -0.32 1.26e-7 Alzheimer's disease (late onset); CESC cis rs2486288 0.656 rs7171312 chr15:45570225 C/G cg09092052 chr15:45571596 NA 0.45 5.33 0.31 2.14e-7 Glomerular filtration rate; CESC cis rs10911232 0.507 rs10797820 chr1:183011366 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.67 0.64 1.52e-32 Hypertriglyceridemia; CESC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg20203395 chr5:56204925 C5orf35 -0.43 -5.06 -0.3 7.66e-7 Initial pursuit acceleration; CESC cis rs9902453 0.902 rs4075014 chr17:28305674 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 8.08 0.44 2.36e-14 Coffee consumption (cups per day); CESC cis rs2180341 0.814 rs9385424 chr6:127726796 A/G cg24812749 chr6:127587940 RNF146 0.84 12.05 0.59 5.93e-27 Breast cancer; CESC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg18350739 chr11:68623251 NA -0.48 -7.14 -0.4 9.06e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06877860 chr20:55043471 C20orf43 -0.5 -6.09 -0.35 4.01e-9 Ulcerative colitis; CESC cis rs3820068 0.603 rs932602 chr1:15986087 A/G cg17385448 chr1:15911702 AGMAT 0.44 7.31 0.41 3.13e-12 Systolic blood pressure; CESC cis rs7666738 0.753 rs1527520 chr4:98929164 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7605827 0.930 rs3805102 chr2:15518312 G/A cg19274914 chr2:15703543 NA 0.35 6.11 0.35 3.61e-9 Educational attainment (years of education); CESC cis rs5757676 1.000 rs5757676 chr22:39841700 T/C cg11247378 chr22:39784982 NA -0.6 -7.16 -0.4 8.03e-12 IgG glycosylation; CESC cis rs763014 0.898 rs1981484 chr16:630710 A/G cg07256732 chr16:621771 PIGQ -0.31 -5.38 -0.31 1.61e-7 Height; CESC cis rs1707322 0.682 rs10890335 chr1:46100394 G/C cg03146154 chr1:46216737 IPP 0.81 11.48 0.58 5.05e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg10523679 chr1:76189770 ACADM 0.55 6.17 0.35 2.53e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2011503 1.000 rs11085264 chr19:19621780 A/G cg11584989 chr19:19387371 SF4 0.61 7.06 0.4 1.45e-11 Bipolar disorder; CESC cis rs7809950 0.724 rs1858888 chr7:107046062 T/A cg23024343 chr7:107201750 COG5 -0.59 -7.45 -0.42 1.35e-12 Coronary artery disease; CESC cis rs7078219 0.505 rs4409764 chr10:101284237 T/G cg09788492 chr10:101292477 NKX2-3 0.34 6.42 0.37 6.25e-10 Dental caries; CESC cis rs4689388 0.581 rs11727100 chr4:6281458 A/C cg00701064 chr4:6280414 WFS1 0.61 7.51 0.42 8.84e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9581857 0.512 rs9581866 chr13:28063176 G/A cg01674679 chr13:27998804 GTF3A -0.64 -5.36 -0.31 1.8e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg05340658 chr4:99064831 C4orf37 0.75 10.74 0.55 1.42e-22 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21679509 chr7:28219613 JAZF1 0.51 6.32 0.36 1.13e-9 Gut microbiome composition (summer); CESC cis rs6540556 0.723 rs6672256 chr1:209894043 A/T cg23920097 chr1:209922102 NA 0.42 5.19 0.3 4.13e-7 Red blood cell count; CESC cis rs1707322 0.752 rs61784793 chr1:46149285 G/A cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg26597838 chr10:835615 NA 1.18 11.37 0.57 1.12e-24 Eosinophil percentage of granulocytes; CESC trans rs10743315 0.557 rs16915108 chr12:19290406 T/C cg09562322 chr12:119419143 SRRM4 -0.48 -6.18 -0.35 2.4e-9 Gut microbiota (bacterial taxa); CESC cis rs2832191 0.967 rs2832216 chr21:30521921 C/T cg08807101 chr21:30365312 RNF160 0.68 9.35 0.5 3.88e-18 Dental caries; CESC cis rs2050392 0.517 rs2771242 chr10:30762973 C/T cg25182066 chr10:30743637 MAP3K8 -0.49 -6.87 -0.39 4.44e-11 Inflammatory bowel disease; CESC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg06877462 chr1:205807181 PM20D1 0.39 5.84 0.34 1.51e-8 Menarche (age at onset); CESC cis rs4727027 0.933 rs6961605 chr7:148870108 G/A cg23583168 chr7:148888333 NA -0.8 -12.19 -0.6 1.96e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.43 0.37 6.07e-10 Prudent dietary pattern; CESC cis rs6542838 0.641 rs12712042 chr2:99534401 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -5.95 -0.34 8.33e-9 Fear of minor pain; CESC cis rs3749237 0.595 rs2878298 chr3:49406080 T/C cg06212747 chr3:49208901 KLHDC8B 0.53 7.21 0.4 5.85e-12 Resting heart rate; CESC cis rs6570726 0.791 rs6918814 chr6:145906028 G/A cg05347473 chr6:146136440 FBXO30 0.55 7.37 0.41 2.13e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1642645 0.757 rs3845574 chr1:42476574 C/A cg16685388 chr1:42384056 HIVEP3 0.38 5.68 0.33 3.57e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg00149659 chr3:10157352 C3orf10 0.73 8.73 0.47 2.94e-16 Alzheimer's disease; CESC cis rs6963495 0.745 rs73192153 chr7:105212418 A/T cg02135003 chr7:105160482 PUS7 -0.48 -5.51 -0.32 8.52e-8 Bipolar disorder (body mass index interaction); CESC cis rs116095464 0.558 rs62347683 chr5:230331 C/T cg20965017 chr5:231967 SDHA -0.45 -5.08 -0.3 7.29e-7 Breast cancer; CESC cis rs921968 0.643 rs508157 chr2:219435288 G/A cg02176678 chr2:219576539 TTLL4 0.41 7.08 0.4 1.27e-11 Mean corpuscular hemoglobin concentration; CESC cis rs910316 1.000 rs7303 chr14:75520065 T/C cg08847533 chr14:75593920 NEK9 0.99 18.49 0.75 1.4e-49 Height; CESC trans rs877282 0.733 rs7092976 chr10:756358 G/A cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs1865721 1.000 rs11659761 chr18:73186974 A/G cg26385618 chr18:73139727 C18orf62 -0.53 -7.94 -0.44 5.65e-14 Intelligence; CESC cis rs4568518 0.710 rs12699930 chr7:18012258 T/C cg03009463 chr7:17980271 SNX13 0.46 6.0 0.35 6.38e-9 Measles; CESC cis rs7296418 0.961 rs11608811 chr12:123529056 A/G cg05973401 chr12:123451056 ABCB9 0.6 7.85 0.43 1.01e-13 Platelet count; CESC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg24147428 chr11:65409760 SIPA1 -0.41 -5.84 -0.34 1.49e-8 Blood pressure (age interaction); CESC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg01448562 chr3:133502909 NA -0.56 -7.78 -0.43 1.66e-13 Iron status biomarkers; CESC cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg23711669 chr6:146136114 FBXO30 -0.93 -12.62 -0.61 6.62e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs2072732 0.861 rs67630839 chr1:2951989 C/T cg15211996 chr1:2936768 ACTRT2 0.33 5.61 0.33 4.97e-8 Plateletcrit; CESC cis rs6570726 0.935 rs9390329 chr6:145828026 T/C cg05347473 chr6:146136440 FBXO30 0.44 5.99 0.35 6.71e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs57506017 0.585 rs7809700 chr7:12267734 G/A cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.58e-7 Neuroticism; CESC cis rs9818941 0.824 rs2712325 chr3:157787473 G/C cg08654915 chr3:157813417 NA -0.45 -7.3 -0.41 3.41e-12 Height; CESC cis rs7524258 0.835 rs75096060 chr1:7270248 G/C cg07173049 chr1:7289937 CAMTA1 0.37 5.61 0.33 5.15e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg02891314 chr5:179741120 GFPT2 -0.58 -7.86 -0.43 1e-13 Height; CESC cis rs1005277 0.522 rs1208767 chr10:38042295 G/T cg00409905 chr10:38381863 ZNF37A -0.5 -6.82 -0.39 6.2e-11 Extrinsic epigenetic age acceleration; CESC cis rs919433 1.000 rs1560277 chr2:198187903 C/T cg10820045 chr2:198174542 NA 0.39 5.72 0.33 2.91e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg03467027 chr4:99064603 C4orf37 0.45 5.61 0.33 4.97e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11690935 0.550 rs4280427 chr2:172813218 G/A cg13550731 chr2:172543902 DYNC1I2 0.46 6.37 0.36 8.38e-10 Schizophrenia; CESC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg21724239 chr8:58056113 NA 0.57 5.84 0.34 1.49e-8 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.863 rs1155576 chr4:120450159 A/C cg09307838 chr4:120376055 NA 0.9 12.26 0.6 1.15e-27 Corneal astigmatism; CESC cis rs16895831 0.519 rs62414629 chr6:42598898 G/A cg10605015 chr6:42532144 UBR2 -0.52 -5.91 -0.34 1.07e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs11048434 0.661 rs34791180 chr12:9110919 T/C cg23795048 chr12:9217529 LOC144571 0.35 5.36 0.31 1.78e-7 Sjögren's syndrome; CESC cis rs7044106 0.791 rs735109 chr9:123488879 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.85 13.76 0.65 7.24e-33 Hip circumference adjusted for BMI; CESC cis rs763014 0.931 rs2071981 chr16:630025 C/G cg00908189 chr16:619842 PIGQ 0.66 9.26 0.49 7.42e-18 Height; CESC cis rs7923609 1.000 rs4379723 chr10:64963449 T/C cg01631684 chr10:65280961 REEP3 -0.45 -5.56 -0.32 6.51e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25187967 chr11:77024606 NA 0.49 6.9 0.39 3.93e-11 Fibrinogen levels; CESC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.17e-12 Tonsillectomy; CESC cis rs1023500 0.573 rs13057094 chr22:42470317 T/C cg04733989 chr22:42467013 NAGA 0.8 11.49 0.58 4.5e-25 Schizophrenia; CESC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg18876405 chr7:65276391 NA -0.51 -5.96 -0.34 8.21e-9 Aortic root size; CESC cis rs3733585 0.753 rs12500805 chr4:10017979 C/T cg11266682 chr4:10021025 SLC2A9 0.69 13.9 0.65 2.39e-33 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg07414643 chr4:187882934 NA 0.55 7.99 0.44 4.15e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs28647808 1.000 rs28489061 chr9:136270319 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs2011503 1.000 rs61744761 chr19:19656615 C/T cg11584989 chr19:19387371 SF4 0.56 6.26 0.36 1.55e-9 Bipolar disorder; CESC cis rs7772486 0.875 rs969694 chr6:146394655 A/G cg23711669 chr6:146136114 FBXO30 0.77 11.48 0.58 4.79e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg10523679 chr1:76189770 ACADM -0.65 -7.22 -0.41 5.56e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs12586317 0.547 rs74243586 chr14:35477325 C/T cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC cis rs644799 1.000 rs7749 chr11:95565789 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.94 14.0 0.65 1.01e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1008375 1.000 rs555 chr4:17625658 A/G cg16339924 chr4:17578868 LAP3 0.56 6.97 0.39 2.49e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9479482 0.967 rs61730071 chr6:150342232 G/A cg03788504 chr6:150331562 NA -0.35 -6.93 -0.39 3.15e-11 Alopecia areata; CESC cis rs7542091 0.704 rs1883331 chr1:210043483 A/G cg23283495 chr1:209979779 IRF6 0.35 5.8 0.34 1.84e-8 Monobrow; CESC cis rs7085104 0.552 rs11191414 chr10:104601565 A/T cg04362960 chr10:104952993 NT5C2 0.5 6.62 0.38 2e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs15676 0.783 rs10819442 chr9:131564750 C/G cg00228799 chr9:131580591 ENDOG -0.49 -6.09 -0.35 3.93e-9 Blood metabolite levels; CESC cis rs9896933 0.775 rs79299098 chr17:80830944 G/A cg19500275 chr17:80737654 TBCD 0.62 5.88 0.34 1.23e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs10870270 0.830 rs11146269 chr10:133761820 G/A cg08754478 chr10:133766260 PPP2R2D -0.58 -7.54 -0.42 7.44e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2228479 0.850 rs12598316 chr16:89916600 C/A cg14709524 chr16:89940631 TCF25 0.87 5.91 0.34 1.04e-8 Skin colour saturation; CESC cis rs77972916 0.536 rs7562101 chr2:43592756 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.5 -5.12 -0.3 5.76e-7 Granulocyte percentage of myeloid white cells; CESC cis rs9308731 0.644 rs3789064 chr2:111915322 T/C cg04202892 chr2:111875749 ACOXL 0.44 6.34 0.36 1.01e-9 Chronic lymphocytic leukemia; CESC cis rs11581903 0.568 rs11205978 chr1:53076057 G/A cg19751897 chr1:52520827 TXNDC12;BTF3L4 0.73 5.47 0.32 1.06e-7 Joint mobility (Beighton score); CESC cis rs796364 0.539 rs6738494 chr2:200697058 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.64 6.22 0.36 1.97e-9 Schizophrenia; CESC cis rs8050907 0.744 rs80031922 chr16:4538185 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.89 5.66 0.33 3.84e-8 Obesity-related traits; CESC cis rs9815354 0.767 rs73071337 chr3:41822518 G/C cg03022575 chr3:42003672 ULK4 0.7 6.2 0.36 2.11e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9611565 0.694 rs9611591 chr22:41830212 G/A cg17376030 chr22:41985996 PMM1 -0.42 -5.1 -0.3 6.56e-7 Vitiligo; CESC cis rs4803468 1.000 rs17318666 chr19:41940342 T/G cg08639244 chr19:41945921 ATP5SL 0.43 5.33 0.31 2.07e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04158115 chr1:36863305 LSM10 0.62 7.07 0.4 1.42e-11 Gut microbiome composition (summer); CESC cis rs10927875 0.632 rs1122068 chr1:16127480 G/C cg18973939 chr1:16164122 FLJ37453 0.37 5.52 0.32 8.2e-8 Dilated cardiomyopathy; CESC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg05368731 chr17:41323189 NBR1 0.76 10.38 0.54 2.05e-21 Menopause (age at onset); CESC trans rs16949788 1.000 rs41315964 chr15:66779698 C/T cg23949574 chr2:240302855 HDAC4 0.44 6.0 0.35 6.53e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7818688 0.653 rs16893774 chr8:95895976 C/G cg16049864 chr8:95962084 TP53INP1 -0.51 -5.14 -0.3 5.47e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg00149659 chr3:10157352 C3orf10 0.73 8.5 0.46 1.35e-15 Alzheimer's disease; CESC cis rs7927592 0.956 rs7116899 chr11:68385535 G/T cg20283391 chr11:68216788 NA -0.48 -5.82 -0.34 1.69e-8 Total body bone mineral density; CESC cis rs2204008 0.837 rs12370891 chr12:37984531 A/G cg26384229 chr12:38710491 ALG10B 0.74 10.84 0.55 6.46e-23 Bladder cancer; CESC cis rs9287719 0.747 rs1534400 chr2:10696833 T/C cg00105475 chr2:10696890 NA 0.44 6.69 0.38 1.29e-10 Prostate cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22966973 chr7:35077753 DPY19L1 -0.53 -6.47 -0.37 4.82e-10 Ulcerative colitis; CESC cis rs763014 0.898 rs35666389 chr16:629458 A/G cg07343612 chr16:622815 PIGQ -0.58 -8.41 -0.46 2.55e-15 Height; CESC trans rs61931739 0.927 rs12315970 chr12:34038535 A/G cg26384229 chr12:38710491 ALG10B -0.47 -6.26 -0.36 1.51e-9 Morning vs. evening chronotype; CESC cis rs7249142 0.506 rs8101388 chr19:19293938 A/C cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.29 5.1 0.3 6.51e-7 IgG glycosylation; CESC cis rs7659604 0.702 rs61217486 chr4:122693973 T/C cg06713675 chr4:122721982 EXOSC9 -0.43 -6.05 -0.35 5.01e-9 Type 2 diabetes; CESC cis rs17253792 0.822 rs76264681 chr14:56060447 T/C cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09214955 chr7:139025759 C7orf55 -0.53 -6.1 -0.35 3.83e-9 Gut microbiome composition (summer); CESC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg11941060 chr3:133502564 NA 0.4 5.27 0.31 2.77e-7 Iron status biomarkers; CESC cis rs4820294 1.000 rs62236668 chr22:38063870 G/A cg21798802 chr22:38057573 PDXP 0.46 7.99 0.44 4.16e-14 Fat distribution (HIV); CESC cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.03e-7 Colorectal cancer; CESC cis rs6088590 0.965 rs6120730 chr20:33385102 G/C cg06115741 chr20:33292138 TP53INP2 0.62 7.52 0.42 8.73e-13 Coronary artery disease; CESC cis rs11718455 0.960 rs11921995 chr3:44017301 C/A cg08738300 chr3:44038990 NA 0.48 6.07 0.35 4.32e-9 Coronary artery disease; CESC cis rs9549367 0.713 rs9549352 chr13:113833221 A/G cg00898013 chr13:113819073 PROZ -0.55 -7.5 -0.42 9.59e-13 Platelet distribution width; CESC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.71 0.43 2.57e-13 Prudent dietary pattern; CESC cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg27347728 chr4:17578864 LAP3 -0.48 -5.42 -0.32 1.34e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9399137 0.507 rs7748708 chr6:135275142 G/A cg22676075 chr6:135203613 NA 0.54 6.88 0.39 4.31e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg02487422 chr3:49467188 NICN1 0.4 5.08 0.3 6.98e-7 Parkinson's disease; CESC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6688613 0.694 rs3820387 chr1:166820284 A/T cg07049167 chr1:166818506 POGK 0.51 6.27 0.36 1.47e-9 Refractive astigmatism; CESC cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.03 0.3 9.1e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04490136 chr11:34073216 CAPRIN1 0.56 6.15 0.35 2.86e-9 Gut microbiome composition (summer); CESC cis rs5997397 0.967 rs5762777 chr22:29150044 T/C cg02153584 chr22:29168773 CCDC117 0.54 7.41 0.41 1.65e-12 Red cell distribution width; CESC cis rs9300255 0.739 rs4759415 chr12:123743674 C/T cg19016782 chr12:123741754 C12orf65 0.5 7.24 0.41 4.8e-12 Neutrophil percentage of white cells; CESC cis rs8114671 0.562 rs6088646 chr20:33505937 T/C cg07148914 chr20:33460835 GGT7 0.45 5.9 0.34 1.09e-8 Height; CESC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 10.0 0.52 3.59e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10781543 0.775 rs10870194 chr9:139327034 A/G cg14169450 chr9:139327907 INPP5E 0.54 8.21 0.45 9.94e-15 Monocyte percentage of white cells; CESC cis rs7259376 0.807 rs7254434 chr19:22500033 G/A cg02657401 chr19:22469223 NA -0.26 -5.27 -0.31 2.84e-7 Menopause (age at onset); CESC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg08888203 chr3:10149979 C3orf24 0.49 6.17 0.35 2.49e-9 Alzheimer's disease; CESC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs901683 1.000 rs34566829 chr10:45973598 G/T cg16031567 chr10:46195673 NA -0.75 -5.04 -0.3 8.78e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs7267979 1.000 rs3002702 chr20:25268920 T/C cg08601574 chr20:25228251 PYGB 0.4 5.74 0.33 2.64e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs8044868 0.530 rs2550870 chr16:72070129 C/T cg01557791 chr16:72042693 DHODH -0.45 -6.26 -0.36 1.54e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7223966 1.000 rs8069687 chr17:61883023 C/T cg11494091 chr17:61959527 GH2 -0.38 -5.18 -0.3 4.41e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs17253792 0.822 rs75555677 chr14:56096429 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs4699052 0.625 rs11097808 chr4:104263130 G/A cg16532752 chr4:104119610 CENPE -0.42 -5.99 -0.35 6.75e-9 Testicular germ cell tumor; CESC cis rs57677839 1 rs57677839 chr11:17028189 G/A cg15378786 chr11:17036137 PLEKHA7 1.1 19.7 0.77 7.94e-54 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17973889 chr20:2644865 IDH3B 0.57 6.19 0.36 2.33e-9 Gut microbiome composition (summer); CESC cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg18351406 chr4:77819688 ANKRD56 0.52 6.44 0.37 5.65e-10 Emphysema distribution in smoking; CESC cis rs4594175 0.926 rs4243570 chr14:51624243 C/T cg23942311 chr14:51606299 NA 0.39 5.93 0.34 9.29e-9 Cancer; CESC cis rs79349575 0.783 rs2088139 chr17:47000110 C/T cg26022315 chr17:47021804 SNF8 0.39 5.3 0.31 2.5e-7 Type 2 diabetes; CESC cis rs1559088 0.947 rs7259879 chr19:33549462 T/C cg17764715 chr19:33622953 WDR88 0.46 5.74 0.33 2.57e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs372883 0.613 rs1153289 chr21:30686212 G/T cg24692254 chr21:30365293 RNF160 -0.53 -6.83 -0.39 5.77e-11 Pancreatic cancer; CESC cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg21573476 chr21:45109991 RRP1B -0.49 -6.88 -0.39 4.4e-11 Mean corpuscular volume; CESC cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg12641515 chr19:46296257 DMWD 0.78 10.2 0.53 7.99e-21 Coronary artery disease; CESC cis rs854765 0.663 rs4925120 chr17:17754633 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.67 -0.38 1.48e-10 Total body bone mineral density; CESC cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg18512352 chr11:47633146 NA -0.51 -7.27 -0.41 4.03e-12 Subjective well-being; CESC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg05332525 chr7:65337924 VKORC1L1 0.49 6.1 0.35 3.67e-9 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16713009 chr19:44223436 IRGC 0.42 6.06 0.35 4.76e-9 Fibrinogen levels; CESC cis rs921968 0.643 rs3931102 chr2:219520405 C/T cg02176678 chr2:219576539 TTLL4 0.44 7.82 0.43 1.29e-13 Mean corpuscular hemoglobin concentration; CESC cis rs9911578 1.000 rs2079703 chr17:56603978 G/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.53 -0.32 7.63e-8 Intelligence (multi-trait analysis); CESC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg22907277 chr7:1156413 C7orf50 0.45 6.36 0.36 8.57e-10 Longevity;Endometriosis; CESC cis rs28489187 0.505 rs7525786 chr1:85884076 C/T cg16011679 chr1:85725395 C1orf52 -0.42 -5.11 -0.3 6.27e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg04254159 chr8:66701461 PDE7A 0.37 6.17 0.35 2.5e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs56104184 0.775 rs56146968 chr19:49398847 A/G cg21252483 chr19:49399788 TULP2 -0.52 -5.64 -0.33 4.45e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.83 10.32 0.54 3.36e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg22535103 chr8:58192502 C8orf71 -0.92 -10.22 -0.53 6.79e-21 Developmental language disorder (linguistic errors); CESC cis rs4975616 0.773 rs414965 chr5:1324121 G/A cg26373071 chr5:1325741 CLPTM1L 0.44 6.9 0.39 3.85e-11 Lung cancer; CESC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.69 -0.33 3.29e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2425143 1.000 rs6060524 chr20:34221155 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -7.96 -0.44 5.22e-14 Blood protein levels; CESC cis rs561341 1.000 rs7210970 chr17:30262169 G/A cg00745463 chr17:30367425 LRRC37B -0.49 -5.29 -0.31 2.57e-7 Hip circumference adjusted for BMI; CESC cis rs709400 1.000 rs58133129 chr14:104104759 A/G cg24130564 chr14:104152367 KLC1 -0.42 -5.37 -0.31 1.73e-7 Body mass index; CESC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg00310523 chr12:86230176 RASSF9 0.37 5.71 0.33 3.06e-8 Major depressive disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23981150 chr1:161111090 NA -0.49 -6.72 -0.38 1.09e-10 Asthma; CESC cis rs8060686 0.920 rs2292318 chr16:67985706 C/T cg26727032 chr16:67993705 SLC12A4 -0.56 -6.18 -0.36 2.36e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs818427 0.820 rs712666 chr5:112227939 T/C cg07820702 chr5:112228657 REEP5 -0.42 -5.24 -0.31 3.32e-7 Total body bone mineral density; CESC cis rs7216064 0.953 rs4790905 chr17:65863350 C/A cg12091567 chr17:66097778 LOC651250 -0.8 -9.03 -0.49 3.62e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9325144 0.647 rs11169258 chr12:39113040 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.47 -0.42 1.14e-12 Morning vs. evening chronotype; CESC cis rs4930103 0.935 rs4930110 chr11:2026701 G/C cg23202291 chr11:1979235 NA 0.37 5.3 0.31 2.5e-7 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg05343316 chr1:45956843 TESK2 -0.5 -6.51 -0.37 3.79e-10 High light scatter reticulocyte count; CESC cis rs1348850 0.872 rs4893959 chr2:178400204 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.78 10.75 0.55 1.28e-22 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs710865 0.541 rs2273046 chr1:19566296 C/T cg13387374 chr1:19411106 UBR4 -0.49 -5.88 -0.34 1.21e-8 Brain structure; CESC cis rs11583043 0.668 rs6681915 chr1:101558521 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.54 0.32 7.3e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg07157834 chr1:205819609 PM20D1 0.7 10.53 0.54 6.73e-22 Menarche (age at onset); CESC cis rs80130819 0.688 rs7313023 chr12:48584179 T/C cg07561017 chr12:48398056 COL2A1 0.39 5.19 0.3 4.22e-7 Prostate cancer; CESC cis rs12705054 1.000 rs17161618 chr7:98801704 A/G cg08595433 chr7:98102096 NA 0.44 5.57 0.32 6.34e-8 Facial emotion recognition (sad faces); CESC cis rs8013055 0.846 rs12717698 chr14:105979015 G/A cg23356831 chr14:105996513 TMEM121 0.38 5.2 0.3 4.03e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC cis rs9486719 0.948 rs2499813 chr6:96875338 T/C cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.76e-8 Migraine;Coronary artery disease; CESC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.55 0.37 2.98e-10 Prudent dietary pattern; CESC cis rs4566357 0.615 rs12328876 chr2:227918899 G/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.02 -0.4 1.84e-11 Coronary artery disease; CESC cis rs2637266 0.669 rs2395426 chr10:78462328 T/C cg18941641 chr10:78392320 NA 0.38 6.66 0.38 1.56e-10 Pulmonary function; CESC cis rs78456975 0.527 rs11886696 chr2:1567841 A/G cg26248373 chr2:1572462 NA -0.57 -6.52 -0.37 3.61e-10 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9910055 0.593 rs58392387 chr17:42297889 A/G cg08499158 chr17:42289980 UBTF -0.49 -6.04 -0.35 5.06e-9 Total body bone mineral density; CESC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg24549020 chr5:56110836 MAP3K1 0.63 6.69 0.38 1.3100000000000001e-10 Initial pursuit acceleration; CESC cis rs9435341 0.930 rs2232015 chr1:107599258 A/T cg09367891 chr1:107599246 PRMT6 0.7 8.42 0.46 2.38e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs72634030 0.510 rs2641244 chr17:5140385 T/C cg24500398 chr17:5266808 RABEP1 -0.63 -5.13 -0.3 5.67e-7 Rheumatoid arthritis; CESC cis rs9549367 0.713 rs3024743 chr13:113821430 C/T cg18105134 chr13:113819100 PROZ -0.65 -8.04 -0.44 2.96e-14 Platelet distribution width; CESC cis rs10887741 0.646 rs4934355 chr10:89425411 G/A cg13926569 chr10:89418898 PAPSS2 0.52 8.18 0.45 1.22e-14 Exercise (leisure time); CESC cis rs9811920 0.638 rs7629426 chr3:99652577 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 5.38 0.31 1.67e-7 Axial length; CESC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg18876405 chr7:65276391 NA -0.54 -7.59 -0.42 5.49e-13 Aortic root size; CESC cis rs870825 0.616 rs12498890 chr4:185636096 C/G cg04058563 chr4:185651563 MLF1IP -0.63 -7.07 -0.4 1.37e-11 Blood protein levels; CESC cis rs2370759 0.945 rs3740237 chr10:32557592 G/C cg01819863 chr10:32635814 EPC1 1.15 9.68 0.51 3.48e-19 Sexual dysfunction (female); CESC cis rs7937682 0.575 rs12808601 chr11:111776066 G/A cg09085632 chr11:111637200 PPP2R1B 0.94 13.08 0.63 1.67e-30 Primary sclerosing cholangitis; CESC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.23 0.41 5.29e-12 Height; CESC cis rs1062177 1.000 rs2016409 chr5:151126324 G/T cg12924095 chr5:151150029 G3BP1 -0.48 -5.84 -0.34 1.53e-8 Preschool internalizing problems; CESC cis rs7520050 0.966 rs785481 chr1:46554518 G/A cg03146154 chr1:46216737 IPP -0.44 -5.69 -0.33 3.34e-8 Red blood cell count;Reticulocyte count; CESC cis rs2997447 0.846 rs61775428 chr1:26409126 G/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.23 0.31 3.44e-7 QRS complex (12-leadsum); CESC cis rs9660992 0.573 rs7531256 chr1:205191202 T/G cg00857998 chr1:205179979 DSTYK 0.54 6.63 0.38 1.93e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg02297831 chr4:17616191 MED28 0.61 7.82 0.43 1.26e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.56 0.32 6.67e-8 Bipolar disorder; CESC cis rs7586673 0.578 rs6723841 chr2:161879616 G/T cg08807892 chr2:162101083 NA 0.4 5.09 0.3 6.64e-7 Intelligence (multi-trait analysis); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg08748207 chr12:46777589 NA -0.45 -6.09 -0.35 3.89e-9 Height; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg21237687 chr17:6899380 ALOX12 0.51 8.9 0.48 9.29e-17 Tonsillectomy; CESC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg25036284 chr2:26402008 FAM59B -0.58 -6.73 -0.38 1.04e-10 Gut microbiome composition (summer); CESC cis rs8017423 0.630 rs12589687 chr14:90819570 C/G cg14092571 chr14:90743983 NA 0.44 6.62 0.38 1.93e-10 Mortality in heart failure; CESC cis rs7927592 0.913 rs10896330 chr11:68254998 A/G cg16797656 chr11:68205561 LRP5 0.41 5.66 0.33 3.96e-8 Total body bone mineral density; CESC cis rs5753618 0.555 rs9609304 chr22:31897795 T/C cg13145458 chr22:31556086 RNF185 -0.53 -6.2 -0.36 2.11e-9 Colorectal cancer; CESC cis rs453301 0.571 rs2929305 chr8:9085217 G/A cg15556689 chr8:8085844 FLJ10661 -0.52 -6.59 -0.38 2.31e-10 Joint mobility (Beighton score); CESC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg19592336 chr6:28129416 ZNF389 0.61 7.97 0.44 4.74e-14 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14510504 chr13:77566830 CLN5 -0.54 -6.38 -0.36 7.65e-10 Gut microbiome composition (summer); CESC trans rs7839040 0.672 rs1507095 chr8:82927310 A/T cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs6088580 0.524 rs6088570 chr20:33268295 T/C cg08999081 chr20:33150536 PIGU -0.44 -6.19 -0.36 2.32e-9 Glomerular filtration rate (creatinine); CESC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg23758822 chr17:41437982 NA 1.01 15.76 0.7 6.41e-40 Menopause (age at onset); CESC cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg11366901 chr6:160182831 ACAT2 0.81 9.81 0.52 1.44e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs1062177 1.000 rs892006 chr5:151180890 G/T cg00977110 chr5:151150581 G3BP1 0.66 7.27 0.41 4.05e-12 Preschool internalizing problems; CESC cis rs6500395 1.000 rs3848322 chr16:48620964 C/A cg04672837 chr16:48644449 N4BP1 0.52 6.56 0.37 2.82e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg05872129 chr22:39784769 NA -0.84 -11.68 -0.58 1.03e-25 Intelligence (multi-trait analysis); CESC cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg20503657 chr10:835505 NA 0.7 6.33 0.36 1.02e-9 Eosinophil percentage of granulocytes; CESC cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg09455208 chr3:40491958 NA 0.42 7.11 0.4 1.1e-11 Renal cell carcinoma; CESC cis rs7666738 0.753 rs10029372 chr4:98859002 T/C cg17366294 chr4:99064904 C4orf37 0.54 7.48 0.42 1.1e-12 Colonoscopy-negative controls vs population controls; CESC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.43 0.37 6.02e-10 Bipolar disorder; CESC cis rs2952156 0.684 rs881844 chr17:37810218 C/G cg00129232 chr17:37814104 STARD3 -0.8 -11.79 -0.59 4.6e-26 Asthma; CESC cis rs1878931 0.543 rs1129568 chr16:3483475 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.98 15.31 0.69 2.38e-38 Body mass index (adult); CESC cis rs67478160 0.619 rs12878682 chr14:104233627 G/C cg08213375 chr14:104286397 PPP1R13B 0.55 11.09 0.56 9.71e-24 Schizophrenia; CESC trans rs7715474 0.706 rs7728674 chr5:120097719 G/C cg12384126 chr1:185285600 IVNS1ABP -0.46 -6.02 -0.35 5.66e-9 Post bronchodilator FEV1/FVC ratio; CESC cis rs11792861 0.888 rs75543406 chr9:111816903 A/T cg05043794 chr9:111880884 C9orf5 -0.39 -6.4 -0.37 6.82e-10 Menarche (age at onset); CESC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg24675658 chr1:53192096 ZYG11B 0.68 8.64 0.47 5.45e-16 Monocyte count; CESC cis rs10949834 0.504 rs77541100 chr7:73555605 C/T cg07137043 chr7:73588983 EIF4H -0.64 -6.94 -0.39 2.98e-11 Verbal memory performance (residualized delayed recall change); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg17164693 chr10:124913828 BUB3 -0.47 -6.16 -0.35 2.65e-9 Height; CESC cis rs965469 0.948 rs6139079 chr20:3314374 C/T cg25506879 chr20:3388711 C20orf194 0.49 5.28 0.31 2.71e-7 IFN-related cytopenia; CESC cis rs863345 0.604 rs12064489 chr1:158499449 T/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs11031096 0.503 rs67065286 chr11:4105273 A/C cg18678763 chr11:4115507 RRM1 -0.53 -7.13 -0.4 9.42e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7395581 0.959 rs901746 chr11:47260319 A/G cg25783544 chr11:47291846 MADD 0.56 7.2 0.4 6.35e-12 HDL cholesterol; CESC cis rs763121 0.853 rs6001185 chr22:39052155 G/A cg06022373 chr22:39101656 GTPBP1 0.88 13.91 0.65 2.06e-33 Menopause (age at onset); CESC cis rs2952156 0.920 rs2934953 chr17:37832315 T/A cg20243544 chr17:37824526 PNMT 0.6 7.35 0.41 2.46e-12 Asthma; CESC cis rs2425143 1.000 rs8124505 chr20:34307247 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.28 0.31 2.7e-7 Blood protein levels; CESC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg22823121 chr1:150693482 HORMAD1 -0.38 -5.95 -0.34 8.59e-9 Tonsillectomy; CESC cis rs35110281 0.837 rs7279958 chr21:45016016 C/A cg04455712 chr21:45112962 RRP1B 0.39 5.88 0.34 1.24e-8 Mean corpuscular volume; CESC cis rs7959452 0.535 rs10878953 chr12:69674187 A/G cg14784868 chr12:69753453 YEATS4 0.66 9.07 0.49 2.78e-17 Blood protein levels; CESC cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg08885076 chr2:99613938 TSGA10 -0.38 -5.06 -0.3 7.82e-7 Chronic sinus infection; CESC cis rs7659604 0.702 rs6815790 chr4:122695385 A/C cg06713675 chr4:122721982 EXOSC9 -0.43 -6.13 -0.35 3.16e-9 Type 2 diabetes; CESC cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2243480 1.000 rs7787230 chr7:65629099 G/A cg12463550 chr7:65579703 CRCP -0.73 -5.71 -0.33 3.1e-8 Diabetic kidney disease; CESC cis rs4835473 0.900 rs67600034 chr4:144655823 C/A cg25736465 chr4:144833511 NA -0.33 -5.22 -0.31 3.68e-7 Immature fraction of reticulocytes; CESC cis rs2932538 0.922 rs11102508 chr1:113141175 T/C cg22162597 chr1:113214053 CAPZA1 0.49 6.48 0.37 4.46e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06538998 chr16:28503160 CLN3 0.54 6.82 0.39 6.01e-11 Gut microbiome composition (summer); CESC cis rs10887741 0.646 rs11202499 chr10:89433211 C/G cg13926569 chr10:89418898 PAPSS2 0.46 6.86 0.39 4.96e-11 Exercise (leisure time); CESC cis rs74181299 0.964 rs2540949 chr2:65284231 A/T cg05010058 chr2:65284262 CEP68 0.34 6.14 0.35 2.99e-9 Pulse pressure; CESC cis rs17666538 0.792 rs7820788 chr8:601846 C/T cg07234876 chr8:600039 NA 0.83 6.53 0.37 3.39e-10 IgG glycosylation; CESC cis rs7923609 0.967 rs10761752 chr10:65160321 T/C cg01631684 chr10:65280961 REEP3 -0.43 -5.41 -0.32 1.41e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg06028605 chr16:24865363 SLC5A11 0.55 7.29 0.41 3.51e-12 Intelligence (multi-trait analysis); CESC cis rs7692995 1.000 rs73098848 chr4:17941027 G/C cg08925142 chr4:18023851 LCORL -0.46 -5.29 -0.31 2.59e-7 Height; CESC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg19729930 chr2:74357872 NA -0.72 -10.19 -0.53 8.94e-21 Gestational age at birth (maternal effect); CESC cis rs13102973 0.965 rs6838419 chr4:135875682 T/C cg14419869 chr4:135874104 NA -0.37 -5.78 -0.33 2.06e-8 Subjective well-being; CESC cis rs1018836 0.847 rs4735225 chr8:91569100 G/C cg16814680 chr8:91681699 NA -0.72 -10.29 -0.53 4.01e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs208520 0.779 rs208451 chr6:66906155 G/A cg07460842 chr6:66804631 NA -0.86 -10.11 -0.53 1.55e-20 Exhaled nitric oxide output; CESC cis rs8058578 0.945 rs885107 chr16:30672719 T/C cg00531865 chr16:30841666 NA -0.44 -5.88 -0.34 1.25e-8 Multiple myeloma; CESC cis rs7937682 0.961 rs7119563 chr11:111543916 T/A cg09085632 chr11:111637200 PPP2R1B 1.02 13.65 0.64 1.69e-32 Primary sclerosing cholangitis; CESC cis rs589448 0.902 rs315113 chr12:69786543 G/T cg20891283 chr12:69753455 YEATS4 -0.85 -13.98 -0.65 1.18e-33 Cerebrospinal fluid biomarker levels; CESC cis rs3768617 0.510 rs10752895 chr1:183068505 C/G ch.1.3577855R chr1:183094577 LAMC1 0.88 14.25 0.66 1.3600000000000001e-34 Fuchs's corneal dystrophy; CESC cis rs447 1.000 rs2067693 chr7:83759570 C/T cg22846510 chr7:83753280 SEMA3A -0.44 -5.38 -0.31 1.64e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12155623 0.619 rs11775403 chr8:49877323 A/T cg22283653 chr8:49824208 NA 0.36 5.34 0.31 2.04e-7 Sudden cardiac arrest; CESC cis rs11792861 0.619 rs2289481 chr9:111712924 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.62 9.52 0.5 1.17e-18 Menarche (age at onset); CESC cis rs2243480 1.000 rs2177703 chr7:65391717 C/A cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs9814567 1.000 rs12637751 chr3:134266124 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg21573476 chr21:45109991 RRP1B -0.56 -7.99 -0.44 4.19e-14 Mean corpuscular volume; CESC cis rs6484504 0.532 rs12222329 chr11:31274340 T/C cg14844989 chr11:31128820 NA -0.41 -5.69 -0.33 3.43e-8 Red blood cell count; CESC cis rs6032067 0.852 rs17333180 chr20:43803708 C/A cg11264863 chr20:43835661 SEMG1 0.5 5.41 0.32 1.41e-7 Blood protein levels; CESC cis rs919433 1.000 rs1346649 chr2:198166117 C/A cg03934865 chr2:198174659 NA -0.45 -6.82 -0.39 6.16e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg08470875 chr2:26401718 FAM59B -0.55 -6.0 -0.35 6.49e-9 Gut microbiome composition (summer); CESC cis rs1348850 0.872 rs4893825 chr2:178298687 A/G cg22681709 chr2:178499509 PDE11A -0.38 -5.26 -0.31 2.98e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7216064 1.000 rs9913471 chr17:65874495 C/T cg12091567 chr17:66097778 LOC651250 -0.81 -9.16 -0.49 1.48e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11785400 0.963 rs6990126 chr8:143728387 T/C cg24634471 chr8:143751801 JRK 0.45 5.84 0.34 1.5e-8 Schizophrenia; CESC cis rs7829975 0.514 rs2976926 chr8:8261624 T/C cg15556689 chr8:8085844 FLJ10661 0.59 7.71 0.43 2.59e-13 Mood instability; CESC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg11764359 chr7:65958608 NA 0.76 9.55 0.51 9.29e-19 Aortic root size; CESC cis rs9815354 0.761 rs73079307 chr3:41862273 A/C cg03022575 chr3:42003672 ULK4 0.69 6.07 0.35 4.53e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9486719 0.843 rs2499789 chr6:96844510 T/C cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg26441486 chr22:50317300 CRELD2 0.42 5.24 0.31 3.33e-7 Schizophrenia; CESC cis rs3820068 0.580 rs12760698 chr1:16009814 G/A cg18133145 chr1:16060689 PLEKHM2 -0.4 -5.05 -0.3 8.31e-7 Systolic blood pressure; CESC cis rs8114671 0.562 rs4911450 chr20:33512406 C/T cg07148914 chr20:33460835 GGT7 0.52 6.8 0.39 6.88e-11 Height; CESC cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg26116260 chr4:7069785 GRPEL1 0.98 14.45 0.66 2.76e-35 Monocyte percentage of white cells; CESC cis rs7147624 0.882 rs1956008 chr14:66085429 G/T cg03016385 chr14:66212404 NA -0.52 -5.26 -0.31 3.01e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs561341 1.000 rs546519 chr17:30297682 T/G cg00745463 chr17:30367425 LRRC37B -0.7 -7.02 -0.4 1.85e-11 Hip circumference adjusted for BMI; CESC cis rs1707322 0.752 rs12047629 chr1:46162802 G/A cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4727027 0.933 rs1044358 chr7:148879951 C/A cg23158103 chr7:148848205 ZNF398 -0.41 -6.54 -0.37 3.15e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs10197940 0.901 rs2290367 chr2:152266731 T/A cg19508488 chr2:152266495 RIF1 0.62 8.28 0.45 6.1e-15 Lung cancer; CESC cis rs17376456 0.877 rs13156865 chr5:93390908 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.36 0.31 1.81e-7 Diabetic retinopathy; CESC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.57 5.61 0.33 4.98e-8 Cerebrospinal P-tau181p levels; CESC cis rs2280018 0.526 rs2966128 chr16:15153389 G/T cg27102117 chr16:15229624 NA 0.53 7.89 0.44 7.75e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg18876405 chr7:65276391 NA 0.5 6.87 0.39 4.63e-11 Aortic root size; CESC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg20887711 chr4:1340912 KIAA1530 0.45 6.07 0.35 4.4e-9 Longevity; CESC cis rs2243480 0.614 rs34032527 chr7:65565141 C/G cg18252515 chr7:66147081 NA -1.39 -13.81 -0.65 4.83e-33 Diabetic kidney disease; CESC cis rs9916302 0.904 rs8065963 chr17:37681332 C/T cg15445000 chr17:37608096 MED1 0.42 6.99 0.39 2.21e-11 Glomerular filtration rate (creatinine); CESC cis rs798766 1.000 rs4865463 chr4:1742400 T/C cg05874882 chr4:1763078 NA -0.58 -8.03 -0.44 3.23e-14 Bladder cancer;Urinary bladder cancer; CESC cis rs6991838 0.551 rs7007505 chr8:66533954 C/G cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs6460942 0.915 rs7803051 chr7:12306904 A/T cg02935154 chr7:12443704 VWDE -0.42 -5.58 -0.32 5.91e-8 Coronary artery disease; CESC cis rs17253792 0.822 rs76612185 chr14:56037706 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.86 5.67 0.33 3.75e-8 Putamen volume; CESC cis rs1538970 0.924 rs12037201 chr1:45941349 G/T cg05343316 chr1:45956843 TESK2 0.9 12.39 0.61 4.15e-28 Platelet count; CESC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg00129232 chr17:37814104 STARD3 0.51 6.35 0.36 9.57e-10 Glomerular filtration rate (creatinine); CESC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg15445000 chr17:37608096 MED1 -0.42 -6.81 -0.39 6.69e-11 Glomerular filtration rate (creatinine); CESC cis rs12545109 0.800 rs1467124 chr8:57418862 T/G cg09654669 chr8:57350985 NA -0.45 -6.27 -0.36 1.47e-9 Obesity-related traits; CESC cis rs6496667 0.865 rs7171617 chr15:90904858 G/A cg22089800 chr15:90895588 ZNF774 0.55 5.58 0.32 5.8e-8 Rheumatoid arthritis; CESC cis rs13385 0.769 rs6878006 chr5:139595751 T/C cg26211634 chr5:139558579 C5orf32 0.46 5.13 0.3 5.68e-7 Atrial fibrillation; CESC cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg07697082 chr8:82753677 SNX16 0.41 6.22 0.36 1.92e-9 Diastolic blood pressure; CESC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg27266027 chr21:40555129 PSMG1 -0.4 -5.13 -0.3 5.63e-7 Cognitive function; CESC cis rs9596863 1.000 rs9536557 chr13:54433190 A/G ch.13.53330881F chr13:54432880 NA -0.63 -5.37 -0.31 1.74e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs6693567 0.545 rs7553647 chr1:150472666 C/T cg09579323 chr1:150459698 TARS2 0.47 5.73 0.33 2.76e-8 Migraine; CESC cis rs2251381 0.778 rs2471947 chr21:30534219 G/T cg24692254 chr21:30365293 RNF160 0.77 10.32 0.54 3.25e-21 Selective IgA deficiency; CESC trans rs698833 0.669 rs1584885 chr2:44647038 A/C cg02851237 chr16:84650990 COTL1 -0.46 -6.07 -0.35 4.39e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs3540 0.554 rs12900987 chr15:91071776 T/C cg22089800 chr15:90895588 ZNF774 -0.64 -8.42 -0.46 2.39e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg17724175 chr1:150552817 MCL1 -0.33 -5.38 -0.31 1.6e-7 Tonsillectomy; CESC cis rs7107174 0.892 rs11601195 chr11:78073501 A/G cg02023728 chr11:77925099 USP35 0.47 6.23 0.36 1.82e-9 Testicular germ cell tumor; CESC cis rs3008870 0.958 rs12143044 chr1:67460054 A/T cg02640540 chr1:67518911 SLC35D1 -0.51 -5.58 -0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg08470875 chr2:26401718 FAM59B -0.48 -5.23 -0.31 3.44e-7 Gut microbiome composition (summer); CESC cis rs4787484 1.000 rs7189750 chr16:29911416 G/A cg01827781 chr16:29875145 LOC440356;CDIPT 0.36 5.05 0.3 8.21e-7 Response to taxane treatment (placlitaxel); CESC cis rs1879734 0.731 rs7512093 chr1:54163207 T/G cg23596471 chr1:54105337 GLIS1 0.33 5.41 0.32 1.38e-7 Mitral valve prolapse; CESC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.72 0.64 9.9e-33 Prudent dietary pattern; CESC cis rs9403521 1.000 rs12208927 chr6:143993634 A/G cg21026257 chr6:143998961 PHACTR2 0.49 5.34 0.31 2.05e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14328907 chr9:125590265 PDCL 0.58 6.52 0.37 3.58e-10 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg00409905 chr10:38381863 ZNF37A -0.51 -6.91 -0.39 3.63e-11 Extrinsic epigenetic age acceleration; CESC cis rs9309473 0.898 rs11126404 chr2:73796924 T/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.51 -0.37 3.74e-10 Metabolite levels; CESC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.9 9.78 0.51 1.73e-19 Platelet count; CESC trans rs2121875 0.667 rs10043545 chr5:44220474 T/A cg07292773 chr6:156718177 NA -0.47 -6.01 -0.35 6.16e-9 Prostate cancer; CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg01516881 chr6:292596 DUSP22 -0.84 -11.29 -0.57 2.11e-24 Menopause (age at onset); CESC cis rs17253792 0.822 rs17253744 chr14:56161950 C/G cg01858014 chr14:56050164 KTN1 -0.98 -7.55 -0.42 6.95e-13 Putamen volume; CESC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs12477438 0.520 rs4851188 chr2:99745898 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.4 0.64 1.33e-31 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14410072 chr9:139838381 C8G;FBXW5 0.56 6.55 0.37 3.06e-10 Gut microbiome composition (summer); CESC cis rs6831352 1.000 rs6532798 chr4:100054827 C/T cg12011299 chr4:100065546 ADH4 0.69 8.57 0.47 8.82e-16 Alcohol dependence; CESC cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg03146154 chr1:46216737 IPP -0.44 -5.5 -0.32 8.79e-8 High light scatter reticulocyte count; CESC cis rs7116495 0.609 rs6592457 chr11:71738086 G/C cg07596299 chr11:71824057 C11orf51 -0.85 -5.06 -0.3 7.92e-7 Severe influenza A (H1N1) infection; CESC cis rs910316 0.712 rs175037 chr14:75465038 T/C cg16144293 chr14:75469539 EIF2B2 0.41 5.43 0.32 1.24e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10681125 chr19:18316102 RAB3A -0.56 -6.42 -0.37 6.13e-10 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg08888203 chr3:10149979 C3orf24 0.53 6.83 0.39 5.8200000000000003e-11 Alzheimer's disease; CESC cis rs9910055 0.529 rs228766 chr17:42186813 A/G cg13607699 chr17:42295918 UBTF -0.45 -5.49 -0.32 9.28e-8 Total body bone mineral density; CESC cis rs2276314 1.000 rs62101367 chr18:33550884 C/T cg19628046 chr18:33552617 C18orf21 0.6 6.7 0.38 1.28e-10 Endometriosis;Drug-induced torsades de pointes; CESC cis rs71277158 0.688 rs2287478 chr3:169788105 A/C cg04067573 chr3:169899625 PHC3 0.72 7.1 0.4 1.16e-11 Prostate cancer; CESC cis rs4604732 0.578 rs12038656 chr1:247623816 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.49 6.04 0.35 5.16e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12444081 chr17:16521159 NA -0.66 -7.9 -0.44 7.47e-14 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs2256998 chr6:146207657 A/C cg23711669 chr6:146136114 FBXO30 0.92 13.35 0.63 1.96e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs1034435 0.755 rs5768680 chr22:48892919 T/C cg05992904 chr22:48892994 FAM19A5 -0.57 -9.8 -0.52 1.53e-19 Late-onset Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11122301 chr12:122255844 SETD1B 0.46 6.15 0.35 2.91e-9 Fibrinogen levels; CESC cis rs6690583 1.000 rs2304641 chr1:85513398 C/T cg11262906 chr1:85462892 MCOLN2 0.51 5.28 0.31 2.71e-7 Serum sulfate level; CESC cis rs10885582 0.781 rs10159857 chr10:116294870 C/A cg17056676 chr10:116301354 ABLIM1 -0.28 -5.14 -0.3 5.47e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs12912251 0.500 rs2643204 chr15:39007171 C/T cg10631289 chr15:39006617 NA -0.49 -5.31 -0.31 2.27e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs4568518 0.616 rs13223642 chr7:18004975 C/T cg03009463 chr7:17980271 SNX13 0.43 5.66 0.33 3.88e-8 Measles; CESC cis rs7267979 0.903 rs1118963 chr20:25247449 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.08 0.68 1.65e-37 Liver enzyme levels (alkaline phosphatase); CESC cis rs3026101 0.671 rs3026128 chr17:5293962 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs829883 0.934 rs249814 chr12:98892964 A/G cg25150519 chr12:98850993 NA 0.71 9.74 0.51 2.31e-19 Colorectal adenoma (advanced); CESC cis rs977987 0.800 rs4888378 chr16:75332041 A/G cg03315344 chr16:75512273 CHST6 0.38 5.47 0.32 1.06e-7 Dupuytren's disease; CESC cis rs6500395 0.928 rs2080509 chr16:48690915 T/C cg04672837 chr16:48644449 N4BP1 -0.51 -6.37 -0.36 8.27e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg02297831 chr4:17616191 MED28 0.63 7.97 0.44 4.82e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12575136 chr18:32820987 ZNF397 0.53 6.25 0.36 1.6e-9 Gut microbiome composition (summer); CESC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg14159672 chr1:205819179 PM20D1 -0.72 -9.63 -0.51 5.21e-19 Menarche (age at onset); CESC cis rs950776 0.706 rs11636753 chr15:78928946 G/T cg06917634 chr15:78832804 PSMA4 0.51 6.44 0.37 5.49e-10 Sudden cardiac arrest; CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg03188948 chr7:1209495 NA 0.69 7.66 0.43 3.45e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3845702 0.736 rs6722147 chr2:180829704 G/A cg01881094 chr2:180872142 CWC22 -1.06 -9.19 -0.49 1.18e-17 Schizophrenia; CESC cis rs7178572 0.568 rs12909924 chr15:77551445 T/G cg22256960 chr15:77711686 NA -0.53 -6.78 -0.38 7.79e-11 Type 2 diabetes; CESC cis rs12928939 0.517 rs9940234 chr16:71964805 C/T cg03805757 chr16:71968109 PKD1L3 -0.56 -6.37 -0.36 8.44e-10 Post bronchodilator FEV1; CESC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg19592336 chr6:28129416 ZNF389 0.43 6.21 0.36 2.05e-9 Cardiac Troponin-T levels; CESC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg18825119 chr6:163149453 PACRG;PARK2 0.51 5.07 0.3 7.6e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.34 0.31 2.01e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs684232 0.623 rs391002 chr17:535441 T/G cg15660573 chr17:549704 VPS53 -0.8 -11.72 -0.58 7.73e-26 Prostate cancer; CESC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs4704187 0.687 rs4447963 chr5:74376309 A/C cg03227963 chr5:74354835 NA 0.32 5.95 0.34 8.68e-9 Response to amphetamines; CESC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg19346786 chr7:2764209 NA -0.46 -6.72 -0.38 1.14e-10 Height; CESC cis rs7584330 0.554 rs13431733 chr2:238430275 A/G cg14458575 chr2:238380390 NA 0.48 5.3 0.31 2.4e-7 Prostate cancer; CESC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg24829409 chr8:58192753 C8orf71 -0.67 -8.18 -0.45 1.19e-14 Developmental language disorder (linguistic errors); CESC cis rs3096299 0.967 rs28575874 chr16:89469890 C/T cg16743903 chr16:89593216 SPG7 -0.41 -5.2 -0.3 4.03e-7 Multiple myeloma (IgH translocation); CESC cis rs748404 0.660 rs2439846 chr15:43740970 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.23 0.45 8.36e-15 Lung cancer; CESC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg04553112 chr3:125709451 NA -0.48 -5.38 -0.31 1.65e-7 Blood pressure (smoking interaction); CESC cis rs9818758 0.607 rs12715434 chr3:49295025 G/C cg00383909 chr3:49044727 WDR6 0.8 6.18 0.36 2.36e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg06221963 chr1:154839813 KCNN3 -0.66 -10.93 -0.56 3.29e-23 Prostate cancer; CESC cis rs11098499 0.909 rs9994810 chr4:120381590 A/G cg09307838 chr4:120376055 NA 0.96 13.95 0.65 1.6e-33 Corneal astigmatism; CESC cis rs763121 0.853 rs35522482 chr22:39063015 C/A cg06022373 chr22:39101656 GTPBP1 0.88 13.95 0.65 1.51e-33 Menopause (age at onset); CESC cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg17775713 chr3:133465469 TF 0.33 5.85 0.34 1.44e-8 Iron status biomarkers (transferrin levels); CESC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg11247378 chr22:39784982 NA -0.6 -8.25 -0.45 7.72e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs2235544 0.579 rs1537321 chr1:54482236 C/A cg09175620 chr1:54484536 LDLRAD1 -0.3 -5.49 -0.32 9.48e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg18404041 chr3:52824283 ITIH1 -0.35 -6.36 -0.36 8.79e-10 Bipolar disorder; CESC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg09177884 chr7:1199841 ZFAND2A -0.45 -5.64 -0.33 4.44e-8 Longevity;Endometriosis; CESC cis rs4836694 0.574 rs3824542 chr9:132936132 C/T cg05251000 chr9:132935664 FREQ 0.48 6.16 0.35 2.68e-9 Alzheimer's disease (cognitive decline); CESC cis rs10242455 0.571 rs11972210 chr7:99206943 A/C cg25640893 chr7:99214727 ZNF498 0.74 5.69 0.33 3.4e-8 Blood metabolite levels; CESC cis rs7264396 0.676 rs58372200 chr20:34555445 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.18 0.36 2.37e-9 Total cholesterol levels; CESC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg17949981 chr6:28129498 ZNF389 -0.39 -5.15 -0.3 5.2e-7 Depression; CESC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg10691866 chr7:65817282 TPST1 -0.33 -5.64 -0.33 4.41e-8 Aortic root size; CESC cis rs668210 0.739 rs1151511 chr11:65756283 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.69 7.56 0.42 6.56e-13 Cerebrospinal fluid biomarker levels; CESC cis rs763121 0.819 rs5757160 chr22:38989646 T/C cg06544989 chr22:39130855 UNC84B 0.5 9.21 0.49 1e-17 Menopause (age at onset); CESC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg26850624 chr5:429559 AHRR -0.5 -6.67 -0.38 1.52e-10 Cystic fibrosis severity; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg19294448 chr17:6900799 ALOX12 -0.33 -5.23 -0.31 3.41e-7 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13825663 chr2:96873994 STARD7 -0.45 -6.0 -0.35 6.56e-9 Fibrinogen levels; CESC cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg22875332 chr1:76189707 ACADM 0.7 9.65 0.51 4.56e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs5498 0.809 rs2075742 chr19:10401607 G/C cg22910295 chr19:10403862 ICAM5 0.42 5.93 0.34 9.22e-9 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs9309473 0.898 rs10185080 chr2:73797507 C/A cg20560298 chr2:73613845 ALMS1 -0.54 -7.11 -0.4 1.1e-11 Metabolite levels; CESC cis rs7208859 0.623 rs216436 chr17:28922900 G/A cg14008862 chr17:28927542 LRRC37B2 0.76 5.62 0.33 4.85e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2425143 1.000 rs56904633 chr20:34400757 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.2 -0.4 6.33e-12 Blood protein levels; CESC cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg27347728 chr4:17578864 LAP3 0.46 5.49 0.32 9.24e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6736093 0.966 rs13020304 chr2:112741535 A/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.45 -0.32 1.17e-7 Coronary artery disease; CESC cis rs3936840 0.539 rs3742441 chr14:102970581 C/G cg18135206 chr14:102964638 TECPR2 0.4 5.07 0.3 7.37e-7 Plateletcrit; CESC cis rs1316952 0.667 rs76411891 chr12:124388236 A/G cg00084347 chr12:124393913 DNAH10 0.4 5.55 0.32 6.78e-8 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg00149659 chr3:10157352 C3orf10 0.7 8.25 0.45 7.27e-15 Alzheimer's disease; CESC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.45e-21 Prudent dietary pattern; CESC cis rs8092503 1.000 rs2009198 chr18:52480795 A/G cg12377874 chr18:52495404 RAB27B 0.38 6.2 0.36 2.13e-9 Childhood body mass index; CESC cis rs7917772 0.636 rs7088981 chr10:104520423 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -5.1 -0.3 6.44e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg03188948 chr7:1209495 NA 0.53 5.98 0.35 7.04e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6460942 0.731 rs7799372 chr7:12233784 T/A cg06484146 chr7:12443880 VWDE -0.47 -5.22 -0.31 3.54e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03425468 chr1:155164676 MIR92B 0.59 7.12 0.4 1e-11 Gut microbiome composition (summer); CESC cis rs11098499 0.909 rs11723757 chr4:120299669 C/T cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg06873352 chr17:61820015 STRADA 0.72 12.61 0.61 7.14e-29 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10024446 chr10:22048429 DNAJC1 -0.58 -6.13 -0.35 3.1e-9 Gut microbiome composition (summer); CESC cis rs644799 1.000 rs644799 chr11:95564259 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.85 0.48 1.3e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6752107 0.967 rs10210302 chr2:234158839 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.35 5.46 0.32 1.11e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs7225537 0.559 rs3744138 chr17:17045861 C/T cg20098446 chr17:17120238 FLCN 0.33 5.13 0.3 5.68e-7 Mean platelet volume; CESC cis rs10131894 0.611 rs175000 chr14:75436367 T/C cg08847533 chr14:75593920 NEK9 -0.76 -12.23 -0.6 1.43e-27 Coronary artery disease; CESC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg08736216 chr1:53307985 ZYG11A -0.42 -7.07 -0.4 1.34e-11 Monocyte count; CESC cis rs13067593 1.000 rs67563589 chr3:188564574 G/C cg17809494 chr3:188572244 LPP 0.35 5.13 0.3 5.74e-7 Immune reponse to smallpox (secreted IFN-alpha); CESC cis rs870825 0.616 rs61653735 chr4:185630025 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.02 0.4 1.86e-11 Blood protein levels; CESC cis rs9303401 0.625 rs34963822 chr17:56988424 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.99 12.05 0.59 5.91e-27 Cognitive test performance; CESC cis rs1707322 0.752 rs28438704 chr1:46170544 G/A cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs17116334 1.000 rs17116334 chr11:113961762 C/T cg21254083 chr11:119598909 PVRL1 0.56 6.48 0.37 4.52e-10 Conduct disorder (maternal expressed emotions interaction); CESC cis rs7208859 0.623 rs76633166 chr17:29113365 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8067354 0.645 rs2102507 chr17:57875907 A/G cg02344993 chr17:57696989 CLTC 0.67 8.28 0.45 6.3e-15 Hemoglobin concentration; CESC cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.23e-9 Extrinsic epigenetic age acceleration; CESC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg07256732 chr16:621771 PIGQ -0.31 -5.38 -0.31 1.67e-7 Height; CESC cis rs910316 0.712 rs175074 chr14:75504454 G/A cg11812906 chr14:75593930 NEK9 -0.8 -13.04 -0.63 2.33e-30 Height; CESC trans rs11039798 0.925 rs7482967 chr11:48613527 T/A cg15704280 chr7:45808275 SEPT13 0.65 6.28 0.36 1.39e-9 Axial length; CESC cis rs11608355 0.705 rs6663 chr12:109886603 G/A cg05360138 chr12:110035743 NA 0.53 5.9 0.34 1.08e-8 Neuroticism; CESC cis rs6500395 0.890 rs9936445 chr16:48617754 T/G cg04672837 chr16:48644449 N4BP1 0.47 5.82 0.34 1.72e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs761746 0.672 rs2236033 chr22:32001050 A/G cg25791279 chr22:32026902 PISD -0.55 -5.78 -0.33 2.1e-8 Intelligence; CESC cis rs7772486 0.902 rs2144476 chr6:146322484 G/A cg23711669 chr6:146136114 FBXO30 0.72 10.34 0.54 2.76e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs2734839 0.964 rs1107162 chr11:113289037 A/G cg14159747 chr11:113255604 NA -0.34 -5.84 -0.34 1.51e-8 Information processing speed; CESC cis rs72627123 0.867 rs58102735 chr14:74467531 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.79 5.74 0.33 2.6e-8 Morning vs. evening chronotype; CESC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg12463550 chr7:65579703 CRCP 0.57 7.22 0.41 5.6e-12 Aortic root size; CESC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg08859206 chr1:53392774 SCP2 0.54 7.12 0.4 1.03e-11 Monocyte count; CESC cis rs1728785 0.892 rs4783562 chr16:68562963 A/G cg02972257 chr16:68554789 NA -0.62 -7.02 -0.4 1.83e-11 Ulcerative colitis; CESC cis rs9814567 0.964 rs9815983 chr3:134222507 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.98 -0.34 7.14e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg17514098 chr12:125302114 SCARB1 -0.49 -6.23 -0.36 1.84e-9 Tetralogy of Fallot; CESC cis rs16866061 1.000 rs1568750 chr2:225342597 A/T cg12698349 chr2:225449008 CUL3 0.73 11.05 0.56 1.37e-23 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC trans rs2018683 1.000 rs4719963 chr7:29011064 A/G cg19402173 chr7:128379420 CALU 0.65 9.23 0.49 8.86e-18 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs11718455 0.960 rs11720974 chr3:43999111 G/C cg08738300 chr3:44038990 NA 0.46 6.22 0.36 1.96e-9 Coronary artery disease; CESC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.28 -0.31 2.7e-7 Life satisfaction; CESC cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg20503657 chr10:835505 NA 1.09 9.88 0.52 8.32e-20 Eosinophil percentage of granulocytes; CESC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg02475777 chr4:1388615 CRIPAK 0.72 9.28 0.5 6.11e-18 Longevity; CESC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg17376030 chr22:41985996 PMM1 0.73 8.0 0.44 3.9e-14 Crohn's disease;Inflammatory bowel disease; CESC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg12193833 chr17:30244370 NA -0.61 -6.18 -0.36 2.36e-9 Hip circumference adjusted for BMI; CESC cis rs79976124 0.842 rs74881738 chr6:66621825 T/G cg07460842 chr6:66804631 NA 0.72 8.33 0.46 4.49e-15 Type 2 diabetes; CESC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg04944784 chr2:26401820 FAM59B -0.93 -10.76 -0.55 1.26e-22 Gut microbiome composition (summer); CESC cis rs17023223 0.537 rs61319010 chr1:119743011 T/A cg05756136 chr1:119680316 WARS2 -0.47 -5.59 -0.32 5.56e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs7100689 0.646 rs7903701 chr10:82129268 T/C cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs7312933 0.703 rs10880259 chr12:42558003 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.47 6.17 0.35 2.57e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs2295499 0.700 rs59425183 chr4:2721199 G/A cg27239842 chr4:2403781 ZFYVE28 -0.3 -5.17 -0.3 4.53e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs8060686 0.565 rs8044328 chr16:68146859 G/C cg26727032 chr16:67993705 SLC12A4 -0.52 -6.3 -0.36 1.24e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10755512 chr3:44666543 ZNF197 -0.52 -6.09 -0.35 3.85e-9 Ulcerative colitis; CESC cis rs2011503 0.941 rs4808944 chr19:19426613 A/C cg11584989 chr19:19387371 SF4 0.67 8.03 0.44 3.2e-14 Bipolar disorder; CESC cis rs9916302 0.629 rs9972882 chr17:37807698 A/C cg20243544 chr17:37824526 PNMT 0.54 6.39 0.37 7.57e-10 Glomerular filtration rate (creatinine); CESC cis rs1832871 0.711 rs9459954 chr6:158709345 G/T cg07165851 chr6:158734300 TULP4 0.56 6.29 0.36 1.27e-9 Height; CESC cis rs3126085 1.000 rs12567463 chr1:152180128 T/A cg03465714 chr1:152285911 FLG 0.43 5.04 0.3 8.56e-7 Atopic dermatitis; CESC cis rs477692 0.549 rs7098548 chr10:131455028 A/G cg05714579 chr10:131428358 MGMT -0.41 -5.58 -0.32 5.97e-8 Response to temozolomide; CESC cis rs1941023 0.584 rs7935082 chr11:60155000 T/C cg08716584 chr11:60157161 MS4A7 -0.6 -10.18 -0.53 9e-21 Congenital heart disease (maternal effect); CESC cis rs7980687 0.628 rs2851443 chr12:123694250 C/T cg00376283 chr12:123451042 ABCB9 0.67 9.21 0.49 1.02e-17 Height;Educational attainment;Head circumference (infant); CESC cis rs9309473 1.000 rs10175180 chr2:73673123 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.22 -0.36 1.95e-9 Metabolite levels; CESC cis rs7786808 0.615 rs4909209 chr7:158194329 C/T cg01191920 chr7:158217561 PTPRN2 -0.32 -5.43 -0.32 1.29e-7 Obesity-related traits; CESC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg23758822 chr17:41437982 NA 1.02 15.6 0.69 2.35e-39 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01413268 chr19:51602462 CTU1 0.4 6.54 0.37 3.2e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10599693 chr2:24300242 SF3B14 0.7 8.21 0.45 9.88e-15 Gut microbiome composition (summer); CESC cis rs9787249 0.957 rs7548120 chr1:40204424 A/T cg02773041 chr1:40204384 PPIE 0.54 7.73 0.43 2.17e-13 Blood protein levels; CESC cis rs2236918 0.687 rs1776176 chr1:242012554 C/T cg17736920 chr1:242011382 EXO1 0.58 7.48 0.42 1.08e-12 Menopause (age at onset); CESC trans rs66573146 0.656 rs66517061 chr4:6935163 C/G cg07817883 chr1:32538562 TMEM39B 1.2 6.85 0.39 5.26e-11 Granulocyte percentage of myeloid white cells; CESC cis rs2455799 0.613 rs7614204 chr3:15792748 A/G cg16303742 chr3:15540471 COLQ -0.39 -6.14 -0.35 3.01e-9 Mean platelet volume; CESC cis rs2635047 0.811 rs12962421 chr18:44787498 A/G cg24371990 chr18:44770781 NA 0.41 6.53 0.37 3.34e-10 Educational attainment; CESC cis rs523522 0.962 rs55848094 chr12:120966659 G/A cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs12348691 0.503 rs10739513 chr9:100592705 C/T cg13688889 chr9:100608707 NA -0.91 -13.3 -0.63 2.87e-31 Alopecia areata; CESC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg17372223 chr3:52568218 NT5DC2 0.44 6.57 0.37 2.69e-10 Bipolar disorder; CESC cis rs17023223 0.537 rs3934789 chr1:119683063 G/A cg05756136 chr1:119680316 WARS2 -0.45 -5.45 -0.32 1.17e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs1568889 1.000 rs12803655 chr11:28060785 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.96 0.56 2.77e-23 Bipolar disorder; CESC trans rs61931739 0.929 rs3912551 chr12:34076696 C/T cg26384229 chr12:38710491 ALG10B -0.47 -6.61 -0.38 2.16e-10 Morning vs. evening chronotype; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06333435 chr8:22102724 POLR3D;MIR320A 0.44 6.07 0.35 4.36e-9 Intelligence (multi-trait analysis); CESC cis rs6691722 0.503 rs3765431 chr1:24706410 T/C cg02336364 chr1:24764700 NIPAL3 0.33 6.8 0.39 6.86e-11 Response to interferon beta in multiple sclerosis; CESC cis rs2777491 1.000 rs7168177 chr15:41715585 A/G cg02330683 chr15:41787940 ITPKA 0.48 7.09 0.4 1.21e-11 Ulcerative colitis; CESC cis rs2154427 0.752 rs79114597 chr21:34200730 C/A cg03746930 chr21:34165763 C21orf62;C21orf49 -0.53 -5.32 -0.31 2.17e-7 Bilirubin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19260885 chr1:113162159 ST7L;CAPZA1 0.56 6.2 0.36 2.2e-9 Gut microbiome composition (summer); CESC trans rs3780486 0.846 rs10758192 chr9:33131651 G/A cg04842962 chr6:43655489 MRPS18A 1.01 19.64 0.77 1.24e-53 IgG glycosylation; CESC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg11941060 chr3:133502564 NA -0.47 -6.5 -0.37 4e-10 Iron status biomarkers; CESC cis rs501120 1.000 rs579058 chr10:44755104 A/G cg09554077 chr10:44749378 NA 0.52 6.89 0.39 3.96e-11 Coronary artery disease;Coronary heart disease; CESC cis rs6835098 1.000 rs1054496 chr4:174089080 A/G cg08422745 chr4:174089978 GALNT7 -0.78 -10.7 -0.55 1.89e-22 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs7095944 0.614 rs7099316 chr10:126469005 G/A cg08799069 chr10:126477246 METTL10 -0.36 -5.22 -0.31 3.53e-7 Asthma; CESC cis rs11098499 0.566 rs17051356 chr4:120585308 C/T cg09307838 chr4:120376055 NA 0.71 8.87 0.48 1.07e-16 Corneal astigmatism; CESC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg21017887 chr14:105400489 NA 0.42 6.87 0.39 4.54e-11 Rheumatoid arthritis; CESC cis rs9660992 0.710 rs7367930 chr1:205235512 A/G cg00857998 chr1:205179979 DSTYK 0.47 5.37 0.31 1.69e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs3126085 0.935 rs12742573 chr1:152260103 A/C cg03465714 chr1:152285911 FLG 0.5 5.75 0.33 2.47e-8 Atopic dermatitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16864825 chr17:37183552 NA 0.42 6.0 0.35 6.48e-9 Gut microbiota (bacterial taxa); CESC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.43 -5.73 -0.33 2.74e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7116495 0.609 rs10751191 chr11:71680920 C/T cg26138937 chr11:71823887 C11orf51 -1.25 -7.99 -0.44 4.19e-14 Severe influenza A (H1N1) infection; CESC cis rs2730245 0.569 rs1188955 chr7:158690866 A/G cg24397884 chr7:158709396 WDR60 0.66 9.39 0.5 2.79e-18 Height; CESC cis rs3749237 0.595 rs6784820 chr3:49450864 C/T cg06212747 chr3:49208901 KLHDC8B -0.51 -6.96 -0.39 2.67e-11 Resting heart rate; CESC cis rs11690935 0.921 rs7594711 chr2:172895637 T/G cg13550731 chr2:172543902 DYNC1I2 -0.9 -12.2 -0.6 1.82e-27 Schizophrenia; CESC cis rs7824557 0.734 rs2293856 chr8:11177447 C/T cg21775007 chr8:11205619 TDH 0.5 7.22 0.41 5.58e-12 Retinal vascular caliber; CESC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.43e-21 Prudent dietary pattern; CESC cis rs6598955 0.671 rs11247910 chr1:26645666 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.35 5.09 0.3 6.68e-7 Obesity-related traits; CESC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg02228329 chr11:64053129 BAD;GPR137 -0.46 -5.67 -0.33 3.67e-8 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs7818345 0.967 rs4549789 chr8:19284015 C/A cg11303988 chr8:19266685 CSGALNACT1 0.35 6.42 0.37 6.41e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs7772486 0.875 rs9403770 chr6:146423334 C/T cg23711669 chr6:146136114 FBXO30 0.86 12.72 0.62 2.98e-29 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04381043 chr16:89341467 ANKRD11 0.48 6.48 0.37 4.34e-10 Fibrinogen levels; CESC cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg05283184 chr6:79620031 NA -0.44 -6.8 -0.39 6.75e-11 Intelligence (multi-trait analysis); CESC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.71 8.87 0.48 1.09e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3736485 0.844 rs8041197 chr15:51865877 T/C cg08986416 chr15:51914746 DMXL2 -0.4 -5.07 -0.3 7.63e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8062405 0.723 rs113208333 chr16:28606160 G/T cg07382826 chr16:28625726 SULT1A1 0.4 6.5 0.37 4.06e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg25019033 chr10:957182 NA 0.59 6.12 0.35 3.41e-9 Eosinophil percentage of granulocytes; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg26594331 chr5:178053244 CLK4 0.47 6.07 0.35 4.4e-9 Neuroticism; CESC cis rs7208859 0.623 rs9894709 chr17:29078454 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg27549887 chr15:48623952 DUT -0.54 -7.19 -0.4 6.46e-12 Ulcerative colitis; CESC cis rs9715521 0.868 rs12650159 chr4:59818550 C/T cg11281224 chr4:60001000 NA -0.52 -6.72 -0.38 1.13e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.34 -6.13 -0.35 3.25e-9 Bipolar disorder; CESC cis rs55823223 0.648 rs936393 chr17:73847613 A/G cg02397686 chr17:73851076 WBP2 0.56 7.18 0.4 6.83e-12 Psoriasis; CESC cis rs6795744 0.901 rs112911837 chr3:13906925 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 -0.52 -5.05 -0.3 8.25e-7 Glomerular filtration rate (creatinine); CESC cis rs4253772 0.591 rs6007740 chr22:46654323 A/G cg09491104 chr22:46646882 C22orf40 0.56 8.65 0.47 5.19e-16 LDL cholesterol;Cholesterol, total; CESC cis rs977987 0.836 rs8055974 chr16:75470986 C/G cg03315344 chr16:75512273 CHST6 0.42 6.07 0.35 4.42e-9 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09423610 chr7:902986 UNC84A -0.55 -6.31 -0.36 1.16e-9 Gut microbiome composition (summer); CESC cis rs4803468 1.000 rs284655 chr19:41928765 C/T cg08639244 chr19:41945921 ATP5SL -0.42 -5.11 -0.3 6.32e-7 Height; CESC cis rs9916302 0.904 rs602688 chr17:37439496 C/T cg07936489 chr17:37558343 FBXL20 -0.77 -11.31 -0.57 1.84e-24 Glomerular filtration rate (creatinine); CESC cis rs3741151 1.000 rs75007932 chr11:73080336 G/A cg17517138 chr11:73019481 ARHGEF17 0.97 6.53 0.37 3.3e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs710216 0.957 rs710215 chr1:43429105 T/C cg03128534 chr1:43423976 SLC2A1 0.53 6.09 0.35 4.06e-9 Red cell distribution width; CESC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.51 -0.32 8.3e-8 Aortic root size; CESC cis rs6460942 0.749 rs79221452 chr7:12202897 T/C cg20607287 chr7:12443886 VWDE -0.56 -5.38 -0.31 1.64e-7 Coronary artery disease; CESC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg03709012 chr19:19516395 GATAD2A 0.95 13.92 0.65 1.92e-33 Tonsillectomy; CESC cis rs933688 1.000 rs61612071 chr5:90741470 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 13.7 0.64 1.17e-32 Smoking behavior; CESC cis rs12477438 0.798 rs9308816 chr2:99637230 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.25 -0.53 5.39e-21 Chronic sinus infection; CESC cis rs36715 0.953 rs2617613 chr5:127552589 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.44 5.12 0.3 5.83e-7 Breast cancer; CESC cis rs1943345 0.686 rs10898088 chr11:82874970 G/A cg07047830 chr11:82868014 PCF11 0.59 7.9 0.44 7.61e-14 Obesity-related traits; CESC cis rs7640424 0.649 rs13094403 chr3:107930210 G/T cg09227934 chr3:107805635 CD47 -0.45 -5.82 -0.34 1.66e-8 Body mass index; CESC cis rs9287719 0.967 rs6735074 chr2:10734766 G/T cg00105475 chr2:10696890 NA -0.37 -5.39 -0.31 1.55e-7 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02786269 chr8:140927326 TRAPPC9 0.51 6.56 0.37 2.73e-10 Fibrinogen levels; CESC cis rs3125734 0.633 rs10740068 chr10:63982254 A/C cg09941381 chr10:64027924 RTKN2 -0.31 -5.09 -0.3 6.96e-7 Rheumatoid arthritis; CESC cis rs7044106 0.791 rs12554440 chr9:123485333 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.86 0.34 1.35e-8 Hip circumference adjusted for BMI; CESC cis rs7546094 1.000 rs2932536 chr1:113202417 G/A cg22162597 chr1:113214053 CAPZA1 -0.39 -6.01 -0.35 6.14e-9 Platelet distribution width; CESC cis rs11122272 0.735 rs10489610 chr1:231517765 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs17125944 0.505 rs17125762 chr14:53289288 A/G cg00686598 chr14:53173677 PSMC6 1.39 10.01 0.52 3.3e-20 Alzheimer's disease (late onset); CESC cis rs72945132 0.882 rs58039907 chr11:70183336 C/T cg14191688 chr11:70257035 CTTN 0.43 5.47 0.32 1.04e-7 Coronary artery disease; CESC cis rs3781458 0.803 rs7088656 chr10:126324077 G/A cg20435097 chr10:126320824 FAM53B 0.3 5.67 0.33 3.65e-8 Male-pattern baldness; CESC cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg18446336 chr7:2847575 GNA12 -0.4 -5.52 -0.32 8.23e-8 Height; CESC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg23281280 chr6:28129359 ZNF389 0.5 6.56 0.37 2.75e-10 Parkinson's disease; CESC cis rs7607369 0.536 rs11892469 chr2:219669488 A/T cg02176678 chr2:219576539 TTLL4 -0.36 -6.16 -0.35 2.75e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC trans rs9858542 0.953 rs6809216 chr3:49412559 G/A cg21659725 chr3:3221576 CRBN -0.54 -6.47 -0.37 4.62e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg00166722 chr3:10149974 C3orf24 0.53 6.52 0.37 3.49e-10 Alzheimer's disease; CESC cis rs6424115 0.830 rs2503000 chr1:24197898 C/G cg10978503 chr1:24200527 CNR2 0.34 6.72 0.38 1.11e-10 Immature fraction of reticulocytes; CESC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg18230493 chr5:56204884 C5orf35 -0.72 -8.57 -0.47 8.6e-16 Initial pursuit acceleration; CESC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg06634786 chr22:41940651 POLR3H -0.73 -7.55 -0.42 6.84e-13 Vitiligo; CESC trans rs17081231 0.590 rs17081545 chr13:67165163 A/T cg20557801 chr15:68121177 LBXCOR1 -0.68 -6.2 -0.36 2.13e-9 Obesity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10029411 chr13:50746245 FAM10A4 -0.47 -6.71 -0.38 1.2e-10 Gut microbiota (bacterial taxa); CESC cis rs2243480 1.000 rs6460260 chr7:65215455 T/C cg18252515 chr7:66147081 NA 1.26 11.9 0.59 1.98e-26 Diabetic kidney disease; CESC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg07701084 chr6:150067640 NUP43 0.44 6.26 0.36 1.5e-9 Lung cancer; CESC cis rs7274811 0.516 rs3213141 chr20:32274380 G/A cg21523528 chr20:32077966 CBFA2T2 0.58 5.92 0.34 9.99e-9 Height; CESC cis rs35110281 0.807 rs9976441 chr21:45046591 G/A cg01579765 chr21:45077557 HSF2BP -0.58 -9.94 -0.52 5.28e-20 Mean corpuscular volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24663683 chr5:39721720 NA -0.52 -7.09 -0.4 1.23e-11 Gut microbiota (bacterial taxa); CESC cis rs72781680 0.898 rs72796171 chr2:23942667 G/C cg20701182 chr2:24300061 SF3B14 0.69 6.2 0.36 2.18e-9 Lymphocyte counts; CESC cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg05283184 chr6:79620031 NA -0.43 -6.5 -0.37 3.94e-10 Intelligence (multi-trait analysis); CESC cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg16339924 chr4:17578868 LAP3 0.63 8.03 0.44 3.19e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2046867 0.862 rs6788139 chr3:72835630 A/G cg25664220 chr3:72788482 NA 0.39 5.21 0.3 3.81e-7 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs11249608 0.548 rs7707587 chr5:178462590 G/C cg01312482 chr5:178451176 ZNF879 -0.45 -6.09 -0.35 3.85e-9 Pubertal anthropometrics; CESC cis rs7659604 0.502 rs13104233 chr4:122672473 T/C cg19671926 chr4:122722719 EXOSC9 0.53 6.61 0.38 2.09e-10 Type 2 diabetes; CESC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg04315214 chr1:2043799 PRKCZ 0.54 9.38 0.5 3.1e-18 Height; CESC cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg18512352 chr11:47633146 NA 0.5 7.15 0.4 8.63e-12 Subjective well-being; CESC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.34 5.96 0.34 8e-9 Bipolar disorder; CESC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg13114125 chr14:105738426 BRF1 -0.9 -11.19 -0.57 4.61e-24 Mean platelet volume;Platelet distribution width; CESC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg09324608 chr17:30823087 MYO1D 0.47 7.03 0.4 1.78e-11 Schizophrenia; CESC cis rs7568458 0.684 rs7608074 chr2:85809703 T/G cg02493740 chr2:85810744 VAMP5 -0.56 -8.24 -0.45 8.01e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs36051895 0.632 rs62541899 chr9:5143291 C/T cg02405213 chr9:5042618 JAK2 -0.5 -6.07 -0.35 4.52e-9 Pediatric autoimmune diseases; CESC cis rs4835473 0.932 rs7687151 chr4:144702834 C/T cg25736465 chr4:144833511 NA -0.33 -5.25 -0.31 3.18e-7 Immature fraction of reticulocytes; CESC cis rs34891900 0.507 rs2535707 chr22:18181869 C/T cg19898043 chr22:18121309 BCL2L13 -0.58 -7.04 -0.4 1.62e-11 Sum neutrophil eosinophil counts; CESC cis rs4722166 0.630 rs4722168 chr7:22779002 G/A cg05472934 chr7:22766657 IL6 0.87 10.94 0.56 3.06e-23 Lung cancer; CESC cis rs13392177 0.660 rs12988046 chr2:219073804 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.52 -6.44 -0.37 5.46e-10 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs11264213 0.591 rs408986 chr1:36551895 C/T cg27506609 chr1:36549197 TEKT2 0.69 6.94 0.39 3.03e-11 Schizophrenia; CESC cis rs35849525 0.814 rs7635601 chr3:50044006 A/T cg03060546 chr3:49711283 APEH -0.47 -5.63 -0.33 4.56e-8 Intelligence (multi-trait analysis); CESC cis rs1055129 0.560 rs2608880 chr17:73938957 C/T cg02678768 chr17:74002944 EVPL 0.38 5.25 0.31 3.07e-7 White matter hyperintensity burden; CESC cis rs916888 0.773 rs199447 chr17:44812188 C/T cg15921436 chr17:44337874 NA 0.75 8.04 0.44 3.04e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7665147 1 rs7665147 chr4:57767327 T/A cg26694713 chr4:57773883 REST 0.58 5.67 0.33 3.77e-8 Platelet count; CESC cis rs10883723 0.775 rs2296579 chr10:104241375 A/G ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.22 0.31 3.57e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs12142240 0.698 rs17413694 chr1:46818416 A/C cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs9788721 0.630 rs77681598 chr15:78906103 C/A cg06917634 chr15:78832804 PSMA4 -0.55 -7.25 -0.41 4.54e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CESC trans rs11098499 0.954 rs6847248 chr4:120225955 A/G cg25214090 chr10:38739885 LOC399744 0.72 9.5 0.5 1.33e-18 Corneal astigmatism; CESC cis rs9583531 0.550 rs7985098 chr13:111386416 G/A cg15841412 chr13:111365552 ING1 0.53 7.08 0.4 1.3e-11 Coronary artery disease; CESC cis rs1348850 0.514 rs4893974 chr2:178497026 A/G cg23306229 chr2:178417860 TTC30B 0.62 6.2 0.36 2.11e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4975709 0.569 rs931509 chr5:1858821 A/T cg15595755 chr5:1867978 NA 0.5 7.79 0.43 1.53e-13 Cardiovascular disease risk factors; CESC cis rs9581857 0.579 rs2780341 chr13:27996401 C/T cg22138327 chr13:27999177 GTF3A -0.65 -5.46 -0.32 1.12e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7772486 0.875 rs6930975 chr6:146387111 C/T cg05347473 chr6:146136440 FBXO30 0.5 6.88 0.39 4.28e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs909674 0.690 rs1972280 chr22:39831986 T/A cg11247378 chr22:39784982 NA -0.58 -8.63 -0.47 5.83e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1008375 0.872 rs2315552 chr4:17627294 A/G cg02297831 chr4:17616191 MED28 0.55 6.97 0.39 2.51e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg22535103 chr8:58192502 C8orf71 -0.96 -9.81 -0.52 1.45e-19 Developmental language disorder (linguistic errors); CESC cis rs2439831 0.702 rs3759791 chr15:44090798 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.73 6.87 0.39 4.58e-11 Lung cancer in ever smokers; CESC cis rs1153858 1.000 rs1049508 chr15:45653592 A/G cg21132104 chr15:45694354 SPATA5L1 0.76 10.2 0.53 8.01e-21 Homoarginine levels; CESC cis rs10463316 0.894 rs12153347 chr5:150765471 C/T cg03212797 chr5:150827313 SLC36A1 -0.46 -6.04 -0.35 5.23e-9 Metabolite levels (Pyroglutamine); CESC cis rs2180341 0.960 rs9398842 chr6:127674662 T/C cg24812749 chr6:127587940 RNF146 1.05 15.15 0.68 9.37e-38 Breast cancer; CESC cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg25783544 chr11:47291846 MADD -0.44 -5.06 -0.3 8e-7 Subjective well-being; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg05323904 chr16:691677 FAM195A 0.48 6.25 0.36 1.67e-9 Systemic lupus erythematosus; CESC cis rs6540559 0.543 rs672819 chr1:210436404 T/A cg25204440 chr1:209979598 IRF6 0.49 5.14 0.3 5.43e-7 Cleft lip with or without cleft palate; CESC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg18350739 chr11:68623251 NA -0.48 -7.53 -0.42 7.98e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9640161 0.750 rs59211922 chr7:150023790 T/G cg10018233 chr7:150070692 REPIN1 0.45 7.41 0.41 1.72e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs2415984 0.562 rs4306423 chr14:46915671 G/A cg14871534 chr14:47121158 RPL10L 0.42 5.94 0.34 9e-9 Number of children ever born; CESC cis rs6088580 0.524 rs6088570 chr20:33268295 T/C cg24642439 chr20:33292090 TP53INP2 -0.45 -5.3 -0.31 2.38e-7 Glomerular filtration rate (creatinine); CESC cis rs9303401 0.538 rs3785493 chr17:56472119 G/T cg10487724 chr17:56770010 TEX14;RAD51C -0.9 -9.5 -0.5 1.3e-18 Cognitive test performance; CESC cis rs7605827 0.930 rs12692261 chr2:15511967 T/G cg19274914 chr2:15703543 NA 0.31 5.5 0.32 8.99e-8 Educational attainment (years of education); CESC cis rs2070997 0.607 rs2261468 chr9:133708873 T/C cg11464064 chr9:133710261 ABL1 0.68 8.07 0.44 2.52e-14 Response to amphetamines; CESC cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg16339924 chr4:17578868 LAP3 -0.59 -7.1 -0.4 1.13e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12477438 0.520 rs10865029 chr2:99718298 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.87 0.7 2.48e-40 Chronic sinus infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14527942 chr3:10276383 IRAK2 0.42 6.35 0.36 9.14e-10 Fibrinogen levels; CESC cis rs2243480 1.000 rs73142162 chr7:65374296 A/T cg18252515 chr7:66147081 NA -1.23 -11.49 -0.58 4.61e-25 Diabetic kidney disease; CESC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs8114671 0.562 rs6088636 chr20:33469746 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.21 0.3 3.79e-7 Height; CESC cis rs7208859 0.673 rs9896095 chr17:29187497 A/G cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg08508325 chr11:3079039 CARS -0.49 -8.42 -0.46 2.38e-15 Longevity; CESC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg27170947 chr2:26402098 FAM59B -0.58 -6.89 -0.39 4.08e-11 Gut microbiome composition (summer); CESC cis rs1552244 0.554 rs17050705 chr3:10046398 G/C cg00149659 chr3:10157352 C3orf10 0.54 6.55 0.37 2.98e-10 Alzheimer's disease; CESC cis rs4566357 1.000 rs6436649 chr2:227923952 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -5.37 -0.31 1.72e-7 Coronary artery disease; CESC cis rs6060717 0.536 rs6060669 chr20:34480557 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -6.89 -0.39 4e-11 Hip circumference adjusted for BMI; CESC cis rs6500395 1.000 rs1420704 chr16:48716902 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs11190604 1.000 rs17746014 chr10:102315354 T/C cg07080220 chr10:102295463 HIF1AN 0.64 6.08 0.35 4.28e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs4727963 0.846 rs1525487 chr7:122710189 G/T cg03640110 chr7:122635026 TAS2R16 -0.38 -5.89 -0.34 1.15e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs748404 0.660 rs693510 chr15:43714625 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.58 7.68 0.43 3.04e-13 Lung cancer; CESC cis rs9611565 0.559 rs132771 chr22:42025350 A/G cg17376030 chr22:41985996 PMM1 -0.8 -9.14 -0.49 1.64e-17 Vitiligo; CESC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg26343298 chr8:95960752 TP53INP1 0.37 5.94 0.34 8.73e-9 Type 2 diabetes; CESC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg24399712 chr22:39784796 NA -0.83 -11.77 -0.59 5.37e-26 Intelligence (multi-trait analysis); CESC trans rs875971 0.660 rs801190 chr7:66033033 C/T cg26939375 chr7:64535504 NA -0.64 -8.8 -0.48 1.77e-16 Aortic root size; CESC cis rs9488822 0.676 rs12202641 chr6:116314634 A/G cg15226275 chr6:116381976 FRK -0.25 -6.37 -0.36 8.17e-10 Cholesterol, total;LDL cholesterol; CESC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.68 0.47 4.11e-16 Menopause (age at onset); CESC cis rs4803468 0.967 rs11670583 chr19:41920440 A/T cg09537434 chr19:41945824 ATP5SL -1.08 -18.9 -0.76 4.86e-51 Height; CESC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.52 0.42 8.58e-13 Prudent dietary pattern; CESC cis rs2191566 0.664 rs62115489 chr19:44578585 A/G cg20607764 chr19:44506953 ZNF230 -0.44 -5.59 -0.32 5.7e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs7584330 0.554 rs6740722 chr2:238393288 T/C cg14458575 chr2:238380390 NA 0.7 6.14 0.35 2.99e-9 Prostate cancer; CESC cis rs11792861 0.926 rs12683988 chr9:111867290 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.41 5.15 0.3 5.08e-7 Menarche (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23956071 chr17:4710044 PLD2 -0.48 -6.34 -0.36 9.65e-10 Ulcerative colitis; CESC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg00310523 chr12:86230176 RASSF9 0.4 6.0 0.35 6.34e-9 Major depressive disorder; CESC cis rs28595532 0.748 rs55949457 chr4:119336174 A/G cg21605333 chr4:119757512 SEC24D 0.94 5.82 0.34 1.7e-8 Cannabis dependence symptom count; CESC cis rs916888 0.773 rs199445 chr17:44817408 C/T cg27589368 chr17:43923255 LOC100128977;IMP5 -0.39 -5.46 -0.32 1.11e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs367943 0.966 rs455435 chr5:112799412 T/C cg12552261 chr5:112820674 MCC -0.62 -7.85 -0.43 1.05e-13 Type 2 diabetes; CESC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg22535103 chr8:58192502 C8orf71 -1.04 -13.38 -0.63 1.56e-31 Developmental language disorder (linguistic errors); CESC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg03188948 chr7:1209495 NA 0.72 6.93 0.39 3.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg12463550 chr7:65579703 CRCP -0.53 -6.77 -0.38 8.05e-11 Aortic root size; CESC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg17971929 chr21:40555470 PSMG1 1.07 16.28 0.71 8.83e-42 Cognitive function; CESC cis rs2637266 0.749 rs4979831 chr10:78457588 G/T cg18941641 chr10:78392320 NA 0.4 7.33 0.41 2.74e-12 Pulmonary function; CESC cis rs2559856 1.000 rs2695284 chr12:102089318 A/G cg12213457 chr12:102090980 CHPT1 0.36 5.48 0.32 9.99e-8 Blood protein levels; CESC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.6 0.55 4.05e-22 Height; CESC cis rs933688 0.536 rs332537 chr5:90794973 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 -0.62 -5.97 -0.34 7.61e-9 Smoking behavior; CESC trans rs55704346 0.566 rs17605267 chr4:25395674 C/A cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs7149337 0.780 rs4369569 chr14:51689181 C/G cg23942311 chr14:51606299 NA -0.52 -8.82 -0.48 1.55e-16 Cancer; CESC cis rs4132509 0.793 rs10927046 chr1:243801190 T/C cg21452805 chr1:244014465 NA 0.61 6.46 0.37 4.94e-10 RR interval (heart rate); CESC cis rs9549260 0.755 rs2755219 chr13:41169625 A/G cg21288729 chr13:41239152 FOXO1 0.61 7.67 0.43 3.32e-13 Red blood cell count; CESC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg12463550 chr7:65579703 CRCP -0.47 -5.83 -0.34 1.58e-8 Aortic root size; CESC cis rs10791097 0.677 rs11222359 chr11:130730648 A/G cg12179176 chr11:130786555 SNX19 0.56 8.12 0.45 1.72e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg12311346 chr5:56204834 C5orf35 -0.64 -8.94 -0.48 7.05e-17 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04190776 chr16:89614921 SPG7 -0.68 -7.86 -0.43 9.82e-14 Gut microbiome composition (summer); CESC cis rs4076764 0.958 rs6691127 chr1:163384831 T/C cg06092702 chr1:163392909 NA -0.4 -5.82 -0.34 1.73e-8 Motion sickness; CESC cis rs654950 0.806 rs10749832 chr1:42041806 C/T cg06885757 chr1:42089581 HIVEP3 0.64 10.41 0.54 1.7e-21 Airway imaging phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10130314 chr10:71993273 PPA1 0.73 8.68 0.47 4.06e-16 Gut microbiome composition (summer); CESC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.67 6.51 0.37 3.73e-10 LDL cholesterol;Cholesterol, total; CESC cis rs11122272 0.735 rs2246645 chr1:231497393 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.76 -0.43 1.87e-13 Hemoglobin concentration; CESC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg13628971 chr7:2884303 GNA12 0.59 7.67 0.43 3.35e-13 Height; CESC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 7.52 0.42 8.66e-13 Cognitive function; CESC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg23161317 chr6:28129485 ZNF389 -0.44 -5.6 -0.33 5.36e-8 Depression; CESC cis rs7937682 0.564 rs11600652 chr11:111754368 A/T cg09085632 chr11:111637200 PPP2R1B 0.92 12.04 0.59 6.56e-27 Primary sclerosing cholangitis; CESC cis rs589448 0.902 rs528974 chr12:69765918 A/T cg20891283 chr12:69753455 YEATS4 0.98 16.88 0.72 6.74e-44 Cerebrospinal fluid biomarker levels; CESC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg20243544 chr17:37824526 PNMT -0.51 -6.87 -0.39 4.53e-11 Self-reported allergy; CESC cis rs6088590 1.000 rs6119530 chr20:33403930 A/G cg06115741 chr20:33292138 TP53INP2 0.62 7.52 0.42 8.6e-13 Coronary artery disease; CESC cis rs28374715 0.578 rs8036026 chr15:41630499 C/G cg02330683 chr15:41787940 ITPKA 0.48 5.65 0.33 4.21e-8 Ulcerative colitis; CESC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg24372256 chr21:43528868 UMODL1;C21orf128 -0.43 -6.17 -0.35 2.59e-9 IgG glycosylation; CESC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg12963246 chr6:28129442 ZNF389 0.59 8.0 0.44 3.89e-14 Depression; CESC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg00339695 chr16:24857497 SLC5A11 0.54 6.33 0.36 1.04e-9 Intelligence (multi-trait analysis); CESC cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg12923728 chr3:195709715 SDHAP1 0.68 9.25 0.49 7.57e-18 Pancreatic cancer; CESC cis rs9915657 0.773 rs9896360 chr17:70099469 C/G cg09344028 chr17:70110421 NA 0.39 7.66 0.43 3.57e-13 Thyroid hormone levels; CESC cis rs7666738 0.609 rs28833816 chr4:98868866 T/C cg17366294 chr4:99064904 C4orf37 0.52 6.68 0.38 1.36e-10 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.686 rs8065497 chr17:17782649 A/G cg09796270 chr17:17721594 SREBF1 -0.43 -5.77 -0.33 2.21e-8 Total body bone mineral density; CESC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg07701084 chr6:150067640 NUP43 0.44 5.95 0.34 8.59e-9 Lung cancer; CESC cis rs9905704 0.846 rs302878 chr17:56762964 G/A cg12560992 chr17:57184187 TRIM37 0.62 7.79 0.43 1.53e-13 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18493449 chr17:74467972 RHBDF2 -0.55 -6.16 -0.35 2.69e-9 Gut microbiome composition (summer); CESC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg03609598 chr5:56110824 MAP3K1 -0.51 -5.32 -0.31 2.22e-7 Initial pursuit acceleration; CESC cis rs4835473 0.932 rs17018238 chr4:144703890 A/T cg25736465 chr4:144833511 NA -0.32 -5.16 -0.3 4.85e-7 Immature fraction of reticulocytes; CESC cis rs6087990 0.899 rs4911262 chr20:31393352 G/A cg13636640 chr20:31349939 DNMT3B 0.92 15.76 0.7 6.03e-40 Ulcerative colitis; CESC cis rs1348850 0.507 rs10186934 chr2:178425998 T/C cg23306229 chr2:178417860 TTC30B 0.7 5.59 0.32 5.72e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs753778 0.602 rs9792 chr8:142205237 C/T cg18755752 chr8:142205143 DENND3 0.69 10.31 0.54 3.54e-21 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs2075371 0.932 rs1862048 chr7:133978167 C/G cg18939928 chr19:1407468 DAZAP1 0.47 6.06 0.35 4.56e-9 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10083149 chr2:3321068 TSSC1 0.45 6.12 0.35 3.3e-9 Fibrinogen levels; CESC cis rs2832191 0.933 rs2832236 chr21:30547602 C/T cg24692254 chr21:30365293 RNF160 -0.65 -9.49 -0.5 1.39e-18 Dental caries; CESC cis rs847577 0.677 rs1495525 chr7:97826232 G/A cg21770322 chr7:97807741 LMTK2 -0.52 -7.44 -0.42 1.44e-12 Breast cancer; CESC cis rs4604732 0.631 rs75320597 chr1:247626751 T/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs60154123 0.505 rs1319435 chr1:210047618 C/T cg25204440 chr1:209979598 IRF6 -0.68 -6.31 -0.36 1.2e-9 Coronary artery disease; CESC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg22508957 chr16:3507546 NAT15 0.7 7.5 0.42 9.39e-13 Tuberculosis; CESC cis rs3749237 0.615 rs6792911 chr3:49429856 C/T cg02487422 chr3:49467188 NICN1 0.53 7.71 0.43 2.55e-13 Resting heart rate; CESC cis rs10242455 0.571 rs6955162 chr7:99184400 T/G cg18809830 chr7:99032528 PTCD1 -0.75 -5.25 -0.31 3.12e-7 Blood metabolite levels; CESC cis rs5769765 0.955 rs8138687 chr22:50291869 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.2 -0.3 4.01e-7 Schizophrenia; CESC cis rs3736485 0.966 rs8042221 chr15:51774613 A/G cg08986416 chr15:51914746 DMXL2 -0.42 -5.54 -0.32 7.22e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11098499 0.779 rs7699346 chr4:120310542 C/T cg09307838 chr4:120376055 NA 0.93 12.77 0.62 2.01e-29 Corneal astigmatism; CESC cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg25019033 chr10:957182 NA -0.61 -6.67 -0.38 1.48e-10 Eosinophil percentage of granulocytes; CESC cis rs9303401 0.625 rs66508449 chr17:56691034 T/C cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.49 0.61 1.91e-28 Cognitive test performance; CESC cis rs1413885 0.549 rs10889546 chr1:65851759 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.48 6.32 0.36 1.13e-9 Anticoagulant levels; CESC cis rs11792861 0.555 rs4978767 chr9:111762925 C/T cg13535736 chr9:111863775 C9orf5 -0.39 -5.59 -0.32 5.77e-8 Menarche (age at onset); CESC cis rs11190604 0.945 rs2495735 chr10:102338609 G/A cg07080220 chr10:102295463 HIF1AN 0.57 5.84 0.34 1.51e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs10744422 1.000 rs897386 chr12:123341289 A/C cg25930673 chr12:123319894 HIP1R -0.69 -5.43 -0.32 1.28e-7 Schizophrenia; CESC cis rs763121 0.853 rs3761454 chr22:39066820 C/T cg21395723 chr22:39101663 GTPBP1 0.42 5.33 0.31 2.15e-7 Menopause (age at onset); CESC cis rs5758511 0.680 rs1107554 chr22:42667594 C/G cg00645731 chr22:42541494 CYP2D7P1 0.58 8.88 0.48 1.02e-16 Birth weight; CESC cis rs11871801 1.000 rs7223784 chr17:40577580 A/C cg21433558 chr17:40837037 CNTNAP1 0.45 5.04 0.3 8.46e-7 Crohn's disease; CESC cis rs523522 0.962 rs4766966 chr12:120942911 G/C cg12219531 chr12:120966889 COQ5 0.75 9.95 0.52 5.02e-20 High light scatter reticulocyte count; CESC cis rs11997175 0.574 rs4364597 chr8:33653729 G/C ch.8.33884649F chr8:33765107 NA 0.66 8.38 0.46 3.14e-15 Body mass index; CESC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg16145915 chr7:1198662 ZFAND2A -0.49 -6.28 -0.36 1.38e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19705215 chr14:61747501 TMEM30B -0.44 -6.02 -0.35 5.93e-9 Ulcerative colitis; CESC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.98 0.39 2.38e-11 Bipolar disorder; CESC cis rs62012628 0.527 rs12438008 chr15:79084680 C/T cg22753661 chr15:79092743 ADAMTS7 -0.44 -5.75 -0.33 2.4e-8 Diastolic blood pressure; CESC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.84 0.34 1.51e-8 Tonsillectomy; CESC cis rs9649465 0.967 rs2299986 chr7:123369539 T/C cg04330084 chr7:123175371 IQUB -0.38 -5.13 -0.3 5.59e-7 Migraine; CESC cis rs9303401 0.614 rs12947982 chr17:57140301 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.9 11.19 0.57 4.72e-24 Cognitive test performance; CESC cis rs644799 0.601 rs662168 chr11:95586982 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.58 8.31 0.45 5.15e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs12604637 0.536 rs16953742 chr18:8555808 C/T ch.18.196065F chr18:8819933 KIAA0802 -0.77 -5.21 -0.3 3.74e-7 Colorectal cancer; CESC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg11987759 chr7:65425863 GUSB -0.48 -6.51 -0.37 3.74e-10 Aortic root size; CESC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg07167872 chr1:205819463 PM20D1 0.75 12.43 0.61 3.05e-28 Menarche (age at onset); CESC cis rs6088590 1.000 rs2295354 chr20:33356541 T/C cg08999081 chr20:33150536 PIGU 0.61 9.39 0.5 2.97e-18 Coronary artery disease; CESC cis rs4629180 0.606 rs13390891 chr2:102111943 T/C cg21388029 chr2:102003306 CREG2 0.32 5.17 0.3 4.65e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.55 0.64 3.99e-32 Prudent dietary pattern; CESC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg10862848 chr6:42927986 GNMT -0.29 -7.09 -0.4 1.2e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9308433 0.529 rs17022608 chr1:214500907 A/C cg06198575 chr1:214491504 SMYD2 0.5 6.01 0.35 6.23e-9 IgG glycosylation; CESC cis rs854765 0.583 rs4553680 chr17:17857722 A/G cg04398451 chr17:18023971 MYO15A -0.67 -9.28 -0.5 6.3e-18 Total body bone mineral density; CESC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg04025307 chr7:1156635 C7orf50 0.45 7.44 0.42 1.41e-12 Longevity;Endometriosis; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg07431429 chr13:21750645 MRP63;SKA3 0.46 6.6 0.38 2.18e-10 Myopia (pathological); CESC cis rs4822044 0.568 rs1883370 chr22:42143740 C/A cg06481639 chr22:41940642 POLR3H 0.58 5.71 0.33 3.05e-8 Cannabis dependence symptom count; CESC cis rs929354 0.772 rs2023975 chr7:157012096 G/A cg05182265 chr7:156933206 UBE3C -0.52 -7.61 -0.42 4.91e-13 Body mass index; CESC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg26338869 chr17:61819248 STRADA 0.69 9.21 0.49 1.04e-17 Prudent dietary pattern; CESC cis rs17039065 0.920 rs59486913 chr4:109384333 T/C cg16022748 chr4:109541635 LOC285456;RPL34 0.6 5.1 0.3 6.35e-7 Gut microbiome composition (summer); CESC cis rs17407555 0.606 rs73229818 chr4:10019884 C/T cg11266682 chr4:10021025 SLC2A9 -0.51 -6.08 -0.35 4.18e-9 Schizophrenia (age at onset); CESC cis rs12134040 0.646 rs12734378 chr1:236511354 A/G cg21399712 chr1:236511386 NA 0.37 5.13 0.3 5.47e-7 Urate levels (BMI interaction); CESC cis rs55794721 0.509 rs7554255 chr1:25778106 C/T cg27572855 chr1:25598939 RHD 0.49 8.31 0.45 4.97e-15 Plateletcrit;Mean corpuscular volume; CESC cis rs2286503 0.780 rs2286506 chr7:22854815 T/C cg13679077 chr7:22862647 TOMM7 0.51 6.51 0.37 3.78e-10 Fibrinogen; CESC cis rs8018808 0.935 rs760257 chr14:77935145 G/A cg20045696 chr14:77926864 AHSA1 0.43 5.91 0.34 1.08e-8 Myeloid white cell count; CESC cis rs8049040 0.586 rs13333985 chr16:71550853 T/C cg08717414 chr16:71523259 ZNF19 -0.62 -6.78 -0.38 7.92e-11 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24541279 chr10:71993373 PPA1 0.62 6.83 0.39 5.85e-11 Gut microbiome composition (summer); CESC cis rs1949733 0.701 rs2688222 chr4:8473735 C/A cg11789530 chr4:8429930 ACOX3 0.65 7.49 0.42 1.01e-12 Response to antineoplastic agents; CESC cis rs754466 0.580 rs10430529 chr10:79582623 C/A cg17075019 chr10:79541650 NA -0.88 -13.79 -0.65 5.74e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg16988008 chr11:108463728 EXPH5 0.45 6.16 0.35 2.68e-9 Bronchopulmonary dysplasia; CESC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg03352830 chr11:487213 PTDSS2 0.74 7.21 0.4 5.99e-12 Body mass index; CESC cis rs4727027 0.704 rs12537763 chr7:148903984 G/A cg23158103 chr7:148848205 ZNF398 -0.31 -5.04 -0.3 8.44e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg18230493 chr5:56204884 C5orf35 0.59 8.03 0.44 3.23e-14 Initial pursuit acceleration; CESC cis rs12142240 0.628 rs56126529 chr1:46808860 C/T cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22345911 chr17:80231263 CSNK1D -0.47 -6.86 -0.39 4.8e-11 Fibrinogen levels; CESC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg22903657 chr4:1355424 KIAA1530 0.41 5.59 0.32 5.69e-8 Obesity-related traits; CESC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg03609598 chr5:56110824 MAP3K1 -0.53 -5.62 -0.33 4.78e-8 Initial pursuit acceleration; CESC cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.38 -5.05 -0.3 8.29e-7 Axial length; CESC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg05564831 chr3:52568323 NT5DC2 0.46 6.93 0.39 3.15e-11 Bipolar disorder; CESC cis rs478304 0.593 rs4645933 chr11:65485120 C/T cg27068330 chr11:65405492 SIPA1 -0.44 -5.07 -0.3 7.43e-7 Acne (severe); CESC cis rs864537 0.676 rs2056626 chr1:167420425 T/G cg09179987 chr1:167433047 CD247 0.51 7.66 0.43 3.45e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs8067545 0.693 rs8066150 chr17:19886948 G/A cg13482628 chr17:19912719 NA 0.4 5.06 0.3 7.98e-7 Schizophrenia; CESC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.82 10.38 0.54 2.04e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs67478160 0.643 rs4906369 chr14:104242458 T/C cg01849466 chr14:104193079 ZFYVE21 -0.52 -7.2 -0.4 6.3e-12 Schizophrenia; CESC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs7223966 1.000 rs61360320 chr17:61800392 C/T cg11494091 chr17:61959527 GH2 0.38 5.17 0.3 4.56e-7 Hip circumference adjusted for BMI;Body mass index; CESC trans rs629535 0.767 rs72654070 chr8:70079369 G/A cg21567404 chr3:27674614 NA -0.89 -10.61 -0.55 3.89e-22 Dupuytren's disease; CESC cis rs6460942 0.908 rs6948654 chr7:12418546 T/A cg10578991 chr7:12443926 VWDE -0.47 -5.42 -0.32 1.34e-7 Coronary artery disease; CESC cis rs7223966 1.000 rs3817181 chr17:61776538 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 6.13 0.35 3.21e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs10028773 0.506 rs12374346 chr4:120281705 G/A cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Educational attainment; CESC cis rs854765 0.583 rs4257260 chr17:17857003 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC cis rs5753618 0.561 rs4141404 chr22:31675185 A/C cg13145458 chr22:31556086 RNF185 0.51 5.68 0.33 3.46e-8 Colorectal cancer; CESC cis rs6088590 1.000 rs2378256 chr20:33292127 G/C cg06115741 chr20:33292138 TP53INP2 0.61 7.45 0.42 1.34e-12 Coronary artery disease; CESC cis rs919433 0.963 rs4850786 chr2:198178608 A/G cg03934865 chr2:198174659 NA 0.43 5.9 0.34 1.09e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs983392 0.679 rs10736701 chr11:60031476 C/T cg13921652 chr1:144931966 PDE4DIP 0.48 6.15 0.35 2.91e-9 Alzheimer's disease (late onset); CESC cis rs2011503 0.943 rs79370636 chr19:19614289 G/A cg11584989 chr19:19387371 SF4 0.62 7.13 0.4 9.66e-12 Bipolar disorder; CESC cis rs9457247 1.000 rs448060 chr6:167382622 A/G cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 5.12e-16 Crohn's disease; CESC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg13902645 chr11:5959945 NA -0.65 -8.98 -0.48 5.31e-17 DNA methylation (variation); CESC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.29 0.57 2.21e-24 Alzheimer's disease; CESC cis rs425277 0.527 rs3107144 chr1:2045380 C/A cg19257562 chr1:2043853 PRKCZ 0.38 6.38 0.37 7.7e-10 Height; CESC cis rs7617773 0.539 rs13087050 chr3:48392800 C/T cg11946769 chr3:48343235 NME6 0.6 7.53 0.42 7.97e-13 Coronary artery disease; CESC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg24531977 chr5:56204891 C5orf35 -0.82 -8.05 -0.44 2.72e-14 Type 2 diabetes; CESC cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg20503657 chr10:835505 NA 1.06 10.03 0.52 2.79e-20 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16098064 chr2:43823287 THADA 0.56 6.57 0.37 2.63e-10 Gut microbiome composition (summer); CESC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg14983838 chr19:29218262 NA 0.5 6.16 0.35 2.67e-9 Methadone dose in opioid dependence; CESC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.29e-7 Life satisfaction; CESC cis rs60871478 0.735 rs4721501 chr7:862166 G/T cg13798912 chr7:905769 UNC84A -0.59 -5.82 -0.34 1.73e-8 Cerebrospinal P-tau181p levels; CESC trans rs208520 0.909 rs58958359 chr6:67021381 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.81 7.68 0.43 3.1400000000000003e-13 Exhaled nitric oxide output; CESC cis rs741677 0.507 rs2075443 chr17:465775 G/A cg15660573 chr17:549704 VPS53 0.56 7.01 0.4 1.98e-11 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); CESC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg13777783 chr17:79615861 NA -0.36 -6.04 -0.35 5.09e-9 Eye color traits; CESC cis rs17608059 0.524 rs9897978 chr17:13900256 G/T cg11395062 chr17:14139857 CDRT15 -0.48 -5.84 -0.34 1.49e-8 Temperament; CESC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 1.000 rs59275611 chr8:58195191 G/A cg05313129 chr8:58192883 C8orf71 -0.59 -6.66 -0.38 1.6e-10 Developmental language disorder (linguistic errors); CESC cis rs67460515 0.563 rs6794882 chr3:160851849 G/A cg03342759 chr3:160939853 NMD3 -0.52 -6.73 -0.38 1.02e-10 Parkinson's disease; CESC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg12463550 chr7:65579703 CRCP -0.49 -6.42 -0.37 6.36e-10 Aortic root size; CESC trans rs2018683 0.584 rs4722880 chr7:28999197 C/T cg19402173 chr7:128379420 CALU -0.58 -7.07 -0.4 1.36e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs8092503 1.000 rs12965081 chr18:52479039 G/A cg12377874 chr18:52495404 RAB27B 0.38 6.27 0.36 1.46e-9 Childhood body mass index; CESC cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg05585544 chr11:47624801 NA -0.47 -6.88 -0.39 4.42e-11 Subjective well-being; CESC cis rs9300255 0.639 rs941306 chr12:123715113 C/T cg00376283 chr12:123451042 ABCB9 0.72 8.84 0.48 1.34e-16 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02046226 chr10:121410475 BAG3 -0.63 -7.31 -0.41 3.08e-12 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15946545 chr13:41345183 MRPS31 0.49 6.19 0.36 2.23e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05899741 chr4:43901084 NA -0.4 -6.35 -0.36 9.51e-10 Gut microbiota (bacterial taxa); CESC cis rs36051895 0.632 rs9657576 chr9:5183028 T/G cg02405213 chr9:5042618 JAK2 -0.53 -6.82 -0.39 6.16e-11 Pediatric autoimmune diseases; CESC trans rs2727020 0.619 rs1829979 chr11:49436875 T/G cg15704280 chr7:45808275 SEPT13 -0.81 -9.74 -0.51 2.41e-19 Coronary artery disease; CESC cis rs926938 0.557 rs6667218 chr1:115238982 G/A cg12756093 chr1:115239321 AMPD1 -0.49 -6.14 -0.35 2.94e-9 Autism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16489582 chr16:28223388 XPO6 0.43 6.1 0.35 3.65e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6938 0.618 rs62029167 chr15:75228350 G/A cg14664628 chr15:75095509 CSK -0.55 -7.17 -0.4 7.52e-12 Breast cancer; CESC cis rs55871839 0.708 rs6651298 chr8:59808307 C/G cg07426533 chr8:59803705 TOX -0.47 -6.74 -0.38 1.01e-10 Pneumonia; CESC cis rs7089973 0.604 rs11196941 chr10:116596258 A/G cg03647239 chr10:116582469 FAM160B1 0.44 5.54 0.32 7.14e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 9.58 0.51 7.12e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10585161 chr5:115420544 COMMD10 -0.45 -6.18 -0.35 2.41e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs2727020 0.617 rs7102702 chr11:49401125 T/G cg15704280 chr7:45808275 SEPT13 -0.82 -10.68 -0.55 2.29e-22 Coronary artery disease; CESC cis rs6061231 1.000 rs11696991 chr20:60959694 G/T cg22633769 chr20:60982531 CABLES2 0.46 5.16 0.3 4.93e-7 Colorectal cancer; CESC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg17971929 chr21:40555470 PSMG1 -0.54 -6.98 -0.39 2.39e-11 Menarche (age at onset); CESC cis rs7208859 0.623 rs2035494 chr17:29130393 T/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs66887589 0.616 rs6843509 chr4:120220196 G/A cg25214090 chr10:38739885 LOC399744 0.43 6.04 0.35 5.13e-9 Diastolic blood pressure; CESC trans rs10242455 0.717 rs2687133 chr7:99332083 C/T cg09045935 chr12:6379348 NA -0.58 -6.08 -0.35 4.15e-9 Blood metabolite levels; CESC cis rs8070740 0.898 rs9303192 chr17:5324836 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.35 0.36 9.3e-10 Menopause (age at onset); CESC cis rs2180341 1.000 rs6569478 chr6:127598619 G/A cg24812749 chr6:127587940 RNF146 1.06 15.23 0.68 4.52e-38 Breast cancer; CESC cis rs35110281 0.805 rs8131005 chr21:45041954 T/C cg01579765 chr21:45077557 HSF2BP -0.51 -8.79 -0.47 1.98e-16 Mean corpuscular volume; CESC cis rs7216064 0.700 rs4791295 chr17:65997317 G/A cg12091567 chr17:66097778 LOC651250 -0.82 -9.07 -0.49 2.67e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6570726 0.935 rs419854 chr6:145844085 A/C cg23711669 chr6:146136114 FBXO30 0.79 11.85 0.59 2.77e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs13385 0.769 rs7722986 chr5:139617386 G/A cg26211634 chr5:139558579 C5orf32 0.48 5.27 0.31 2.79e-7 Atrial fibrillation; CESC cis rs12477438 0.765 rs2309521 chr2:99592069 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg18230493 chr5:56204884 C5orf35 -0.73 -8.57 -0.47 8.93e-16 Initial pursuit acceleration; CESC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg20243544 chr17:37824526 PNMT -0.47 -5.94 -0.34 9.04e-9 Glomerular filtration rate (creatinine); CESC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg07952391 chr2:88470173 THNSL2 0.63 6.17 0.35 2.55e-9 Plasma clusterin levels; CESC cis rs6977660 0.652 rs12673842 chr7:19747437 T/C cg05791153 chr7:19748676 TWISTNB 0.78 6.75 0.38 9.56e-11 Thyroid stimulating hormone; CESC cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg08213375 chr14:104286397 PPP1R13B 0.33 5.46 0.32 1.07e-7 Reticulocyte count; CESC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg22903471 chr2:27725779 GCKR -0.45 -6.26 -0.36 1.53e-9 Total body bone mineral density; CESC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.79 13.19 0.63 6.86e-31 Personality dimensions; CESC cis rs67311347 1.000 rs897117 chr3:40437294 C/T cg24209194 chr3:40518798 ZNF619 -0.41 -5.42 -0.32 1.34e-7 Renal cell carcinoma; CESC cis rs7666738 0.830 rs7689495 chr4:98920152 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.32 0.31 2.17e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2262909 0.962 rs11673195 chr19:22313814 T/C cg11619707 chr19:22235551 ZNF257 0.33 5.31 0.31 2.35e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs9291683 0.597 rs11722989 chr4:10126139 A/G cg11266682 chr4:10021025 SLC2A9 -0.46 -8.32 -0.45 4.84e-15 Bone mineral density; CESC cis rs7937682 0.632 rs4936834 chr11:111764017 T/A cg22437258 chr11:111473054 SIK2 -0.5 -5.53 -0.32 7.78e-8 Primary sclerosing cholangitis; CESC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg27121462 chr16:89883253 FANCA -0.49 -5.82 -0.34 1.69e-8 Vitiligo; CESC cis rs10754283 0.967 rs6428559 chr1:90099036 C/T cg21401794 chr1:90099060 LRRC8C 0.7 9.26 0.49 7.18e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.73 9.9 0.52 7.25e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg07701084 chr6:150067640 NUP43 0.41 5.37 0.31 1.72e-7 Lung cancer; CESC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.26 0.31 3.02e-7 Electroencephalogram traits; CESC cis rs6598955 0.670 rs6598942 chr1:26531034 C/T cg04990556 chr1:26633338 UBXN11 -0.75 -10.55 -0.54 5.96e-22 Obesity-related traits; CESC cis rs941873 0.868 rs2181080 chr10:81121960 A/G cg08514558 chr10:81106712 PPIF 0.36 6.15 0.35 2.77e-9 Height; CESC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg26338869 chr17:61819248 STRADA 0.73 9.64 0.51 4.77e-19 Prudent dietary pattern; CESC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg24562669 chr7:97807699 LMTK2 0.52 7.41 0.41 1.7e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs832540 0.519 rs10036895 chr5:56273693 G/A cg24531977 chr5:56204891 C5orf35 -0.42 -5.23 -0.31 3.53e-7 Coronary artery disease; CESC cis rs10504229 0.516 rs7821160 chr8:57986281 C/T cg24829409 chr8:58192753 C8orf71 0.36 5.18 0.3 4.35e-7 Developmental language disorder (linguistic errors); CESC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 11.46 0.58 5.94e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7267979 0.932 rs446649 chr20:25467359 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.75 14.46 0.66 2.46e-35 Liver enzyme levels (alkaline phosphatase); CESC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg11890956 chr21:40555474 PSMG1 -1.01 -15.8 -0.7 4.48e-40 Cognitive function; CESC cis rs3008870 0.727 rs4582760 chr1:67464394 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.63 -8.34 -0.46 4.02e-15 Lymphocyte percentage of white cells; CESC cis rs9291683 0.610 rs993173 chr4:10323935 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -8.6 -0.47 7.15e-16 Bone mineral density; CESC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg04414720 chr1:150670196 GOLPH3L 0.44 5.84 0.34 1.49e-8 Melanoma; CESC cis rs55692411 0.537 rs71326904 chr3:49991060 C/T cg03060546 chr3:49711283 APEH -0.47 -5.43 -0.32 1.3e-7 Intelligence (multi-trait analysis); CESC cis rs12973672 1.000 rs10421768 chr19:35772899 A/G cg12095397 chr19:35769544 USF2 0.51 7.12 0.4 1.01e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7216064 1.000 rs3935969 chr17:65881959 A/G cg07042672 chr17:66097459 LOC651250 -0.57 -6.54 -0.37 3.09e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9291683 0.566 rs13144709 chr4:10044182 C/T cg00071950 chr4:10020882 SLC2A9 0.81 13.65 0.64 1.7e-32 Bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05542295 chr17:55162876 AKAP1 -0.42 -6.06 -0.35 4.55e-9 Gambling; CESC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg03388025 chr16:89894329 SPIRE2 0.4 7.89 0.44 7.74e-14 Vitiligo; CESC cis rs11676348 0.791 rs4133195 chr2:218951245 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.4 5.42 0.32 1.33e-7 Ulcerative colitis; CESC cis rs4237845 0.636 rs11172371 chr12:58286188 C/T cg00677455 chr12:58241039 CTDSP2 0.74 9.25 0.49 7.78e-18 Intelligence (multi-trait analysis); CESC cis rs6087990 0.899 rs4911110 chr20:31392366 C/T cg13636640 chr20:31349939 DNMT3B -0.89 -15.81 -0.7 4.09e-40 Ulcerative colitis; CESC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg12463550 chr7:65579703 CRCP 0.59 7.52 0.42 8.29e-13 Aortic root size; CESC cis rs3820068 0.705 rs72645808 chr1:15870118 G/C cg17385448 chr1:15911702 AGMAT 0.4 6.03 0.35 5.62e-9 Systolic blood pressure; CESC cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg11752832 chr7:134001865 SLC35B4 -0.52 -6.61 -0.38 2.15e-10 Mean platelet volume; CESC trans rs208520 0.690 rs10944872 chr6:66708239 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.55 0.58 2.9e-25 Exhaled nitric oxide output; CESC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg00484396 chr16:3507460 NAT15 0.44 7.27 0.41 4.08e-12 Tuberculosis; CESC cis rs6061231 0.631 rs2427318 chr20:60975727 G/T cg24112000 chr20:60950667 NA -0.54 -8.45 -0.46 1.94e-15 Colorectal cancer; CESC cis rs193541 0.632 rs119449 chr5:122283741 T/G cg19412675 chr5:122181750 SNX24 0.48 5.59 0.32 5.57e-8 Glucose homeostasis traits; CESC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs660498 0.507 rs34773871 chr10:27727645 G/A cg11203244 chr10:27609286 NA 0.38 5.09 0.3 6.82e-7 Asthma (childhood onset); CESC cis rs15676 0.783 rs7860949 chr9:131586883 C/T cg00228799 chr9:131580591 ENDOG -0.55 -7.07 -0.4 1.41e-11 Blood metabolite levels; CESC cis rs1707322 0.656 rs2991981 chr1:46057144 A/G cg03146154 chr1:46216737 IPP -0.75 -10.01 -0.52 3.19e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9549367 0.789 rs2287244 chr13:113887173 C/G cg18105134 chr13:113819100 PROZ 0.59 7.38 0.41 2.03e-12 Platelet distribution width; CESC cis rs7845219 0.544 rs34208552 chr8:95908067 C/G cg09323728 chr8:95962352 TP53INP1 -0.34 -6.53 -0.37 3.36e-10 Type 2 diabetes; CESC cis rs2046867 0.862 rs62251657 chr3:72832076 C/T cg25664220 chr3:72788482 NA -0.44 -6.22 -0.36 1.9e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg23978390 chr7:1156363 C7orf50 0.52 6.89 0.39 4.14e-11 Longevity;Endometriosis; CESC cis rs4969178 0.622 rs11657987 chr17:76387363 G/T cg05887092 chr17:76393375 PGS1 0.66 10.94 0.56 3.05e-23 HDL cholesterol levels; CESC cis rs4523957 0.647 rs12950603 chr17:2194937 T/A cg16513277 chr17:2031491 SMG6 0.6 8.1 0.45 1.97e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.62 -0.33 4.88e-8 Menopause (age at onset); CESC cis rs6547741 1.000 rs1972669 chr2:27767107 T/G cg21248554 chr2:27665150 KRTCAP3 0.24 5.06 0.3 7.83e-7 Oral cavity cancer; CESC cis rs10883723 0.773 rs715439 chr10:104257809 A/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Allergic disease (asthma, hay fever or eczema); CESC trans rs55704346 0.566 rs13434763 chr4:25388590 T/C cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs4900538 0.821 rs12586673 chr14:102827643 C/T cg18135206 chr14:102964638 TECPR2 -0.72 -8.71 -0.47 3.32e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs742614 0.533 rs2747541 chr20:32418772 G/T cg06304546 chr20:32448765 NA -0.42 -5.38 -0.31 1.67e-7 Stearic acid (18:0) levels; CESC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg05564831 chr3:52568323 NT5DC2 0.44 6.58 0.37 2.57e-10 Bipolar disorder; CESC cis rs1143633 0.530 rs4538207 chr2:113701863 G/T cg12858261 chr2:113808755 IL1F8 0.45 5.47 0.32 1.03e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs9443189 0.570 rs775072 chr6:76377998 G/A cg01950844 chr6:76311363 SENP6 -0.87 -9.27 -0.49 6.59e-18 Prostate cancer; CESC trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg15704280 chr7:45808275 SEPT13 -0.57 -6.94 -0.39 3.04e-11 Coronary artery disease; CESC cis rs1729951 0.546 rs12054408 chr3:136677645 T/C cg04103450 chr3:136751342 NA 0.4 5.28 0.31 2.66e-7 Neuroticism; CESC cis rs7618501 0.966 rs7372966 chr3:49788969 T/C cg24308560 chr3:49941425 MST1R 0.51 6.95 0.39 2.89e-11 Intelligence (multi-trait analysis); CESC cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg18305652 chr10:134549665 INPP5A 0.5 7.59 0.42 5.45e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs881375 0.678 rs7021049 chr9:123683982 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.44 6.21 0.36 2.04e-9 Rheumatoid arthritis; CESC cis rs6939532 0.517 rs733528 chr6:26374903 A/G cg14345882 chr6:26364793 BTN3A2 0.38 6.0 0.35 6.37e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9612 0.718 rs173202 chr19:44253588 C/T cg08581076 chr19:44259116 C19orf61 0.46 5.71 0.33 3e-8 Exhaled nitric oxide output; CESC cis rs2559856 1.000 rs2695285 chr12:102089043 G/A cg15068132 chr12:102092402 CHPT1 -0.43 -5.71 -0.33 3.02e-8 Blood protein levels; CESC cis rs10465746 0.570 rs2147950 chr1:84465545 C/T cg10977910 chr1:84465055 TTLL7 0.45 5.85 0.34 1.41e-8 Obesity-related traits; CESC cis rs10744422 0.858 rs4759389 chr12:123308615 A/G cg25930673 chr12:123319894 HIP1R -0.65 -5.23 -0.31 3.4e-7 Schizophrenia; CESC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg03538708 chr1:25844672 NA -0.36 -5.29 -0.31 2.62e-7 Erythrocyte sedimentation rate; CESC cis rs10504073 0.647 rs10105794 chr8:50012793 G/C cg00325661 chr8:49890786 NA 0.5 7.68 0.43 3.16e-13 Blood metabolite ratios; CESC cis rs6866344 0.697 rs62392831 chr5:178134365 A/G cg10224037 chr5:178157518 ZNF354A 0.67 7.34 0.41 2.64e-12 Neutrophil percentage of white cells; CESC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg04287289 chr16:89883240 FANCA -0.92 -16.4 -0.71 3.2e-42 Vitiligo; CESC cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.73 9.02 0.48 3.82e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg04450456 chr4:17643702 FAM184B 0.36 5.15 0.3 5.16e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg01988459 chr11:68622903 NA -0.39 -5.21 -0.3 3.76e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg07507251 chr3:52567010 NT5DC2 0.47 9.07 0.49 2.67e-17 Electroencephalogram traits; CESC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg17178900 chr1:205818956 PM20D1 0.38 5.12 0.3 5.81e-7 Parkinson's disease; CESC cis rs59918340 0.548 rs10102728 chr8:142205964 G/A cg23750338 chr8:142222470 SLC45A4 0.42 5.97 0.34 7.43e-9 Immature fraction of reticulocytes; CESC cis rs698833 0.780 rs9309115 chr2:44510146 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 6.17 0.35 2.61e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs9457247 0.646 rs239934 chr6:167412048 G/A cg25258033 chr6:167368657 RNASET2 0.39 6.01 0.35 6.04e-9 Crohn's disease; CESC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg22800045 chr5:56110881 MAP3K1 0.8 10.05 0.53 2.5e-20 Initial pursuit acceleration; CESC cis rs4888262 0.526 rs4887776 chr16:74635632 A/G cg01733217 chr16:74700730 RFWD3 0.86 11.84 0.59 2.98e-26 Testicular germ cell tumor; CESC cis rs2274273 0.805 rs10131926 chr14:55713246 T/C cg04306507 chr14:55594613 LGALS3 0.29 5.83 0.34 1.65e-8 Protein biomarker; CESC cis rs7786808 0.615 rs1563066 chr7:158194935 A/C cg09998033 chr7:158218633 PTPRN2 -0.39 -5.65 -0.33 4.05e-8 Obesity-related traits; CESC cis rs9303401 0.659 rs62081316 chr17:56781499 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg20476274 chr7:133979776 SLC35B4 0.68 10.07 0.53 2.09e-20 Mean platelet volume; CESC cis rs12477438 0.798 rs6736064 chr2:99658201 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.01 0.56 1.89e-23 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02764006 chr17:65029280 CACNG4 -0.51 -6.38 -0.36 8.01e-10 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs6866632 chr5:264429 C/G cg22496380 chr5:211416 CCDC127 -0.82 -8.86 -0.48 1.18e-16 Breast cancer; CESC cis rs2243480 0.901 rs73148097 chr7:65431787 A/C cg12463550 chr7:65579703 CRCP 0.69 5.5 0.32 9.16e-8 Diabetic kidney disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12187437 chr12:66524584 LLPH -0.44 -6.33 -0.36 1.04e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25824265 chr7:132766817 CHCHD3 0.59 6.43 0.37 5.85e-10 Gut microbiome composition (summer); CESC cis rs10752881 0.933 rs2027086 chr1:183057933 G/A ch.1.3577855R chr1:183094577 LAMC1 0.85 13.71 0.64 1.08e-32 Colorectal cancer; CESC cis rs1355223 0.867 rs11821793 chr11:34681462 A/G cg11058730 chr11:34937778 PDHX;APIP -0.49 -6.41 -0.37 6.59e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs12220238 1.000 rs10824128 chr10:76007903 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.1 0.35 3.7e-9 Soluble interleukin-2 receptor subunit alpha; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg19491415 chr10:32217948 ARHGAP12 0.43 6.07 0.35 4.32e-9 Bronchopulmonary dysplasia; CESC cis rs7647973 0.769 rs4974081 chr3:49070499 A/G cg06212747 chr3:49208901 KLHDC8B -0.47 -5.59 -0.32 5.75e-8 Menarche (age at onset); CESC cis rs4727963 0.777 rs7781708 chr7:122719076 G/T cg03640110 chr7:122635026 TAS2R16 -0.35 -5.36 -0.31 1.82e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs7772486 0.875 rs1412080 chr6:146417304 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.87 0.39 4.66e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6598955 0.724 rs3924934 chr1:26644079 A/G cg04990556 chr1:26633338 UBXN11 -0.72 -9.8 -0.52 1.49e-19 Obesity-related traits; CESC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg09359103 chr1:154839909 KCNN3 -0.67 -12.81 -0.62 1.45e-29 Prostate cancer; CESC cis rs997295 0.520 rs4776971 chr15:68081097 C/A cg08079166 chr15:68083412 MAP2K5 0.4 6.42 0.37 6.19e-10 Motion sickness; CESC cis rs4654899 0.802 rs3767247 chr1:21227338 T/C cg05370193 chr1:21551575 ECE1 0.39 5.63 0.33 4.63e-8 Superior frontal gyrus grey matter volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04995826 chr11:43333458 API5 -0.41 -6.09 -0.35 3.97e-9 Gambling; CESC cis rs2070488 0.775 rs13098946 chr3:38517784 C/G cg24069376 chr3:38537580 EXOG 0.35 5.88 0.34 1.22e-8 Electrocardiographic conduction measures; CESC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg00149659 chr3:10157352 C3orf10 0.71 8.4 0.46 2.72e-15 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09662798 chr17:73498302 CASKIN2 0.41 6.17 0.35 2.5e-9 Fibrinogen levels; CESC cis rs10751667 1.000 rs10902246 chr11:953674 T/C cg20946044 chr11:1010712 AP2A2 -0.41 -5.48 -0.32 9.89e-8 Alzheimer's disease (late onset); CESC cis rs2273669 0.667 rs78383792 chr6:109312498 A/G cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs7666738 0.819 rs13120307 chr4:99036100 A/C cg03467027 chr4:99064603 C4orf37 0.48 5.92 0.34 9.73e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3733585 0.699 rs10001964 chr4:9959275 C/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.83 -0.59 3.28e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.93 10.91 0.56 4.02e-23 Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12091641 chr8:145180933 NA 0.45 6.49 0.37 4.16e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23143233 chr20:57465864 GNAS -0.56 -6.16 -0.35 2.68e-9 Gut microbiome composition (summer); CESC cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg04362960 chr10:104952993 NT5C2 -0.48 -6.09 -0.35 4e-9 Immature fraction of reticulocytes;Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17983724 chr7:72298804 TYW1B;SBDSP -0.45 -6.17 -0.35 2.5e-9 Fibrinogen levels; CESC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg26314531 chr2:26401878 FAM59B -0.75 -8.29 -0.45 5.77e-15 Gut microbiome composition (summer); CESC cis rs57506017 0.585 rs6460897 chr7:12252741 T/G cg23422036 chr7:12250390 TMEM106B 0.38 5.12 0.3 5.83e-7 Neuroticism; CESC cis rs4835473 0.900 rs10025455 chr4:144919570 C/G cg25736465 chr4:144833511 NA -0.46 -6.94 -0.39 2.96e-11 Immature fraction of reticulocytes; CESC cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg25208724 chr1:156163844 SLC25A44 1.01 18.98 0.76 2.67e-51 Testicular germ cell tumor; CESC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg15782153 chr7:917662 C7orf20 0.52 5.72 0.33 2.91e-8 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00737992 chr20:55098859 GCNT7;C20orf106 -0.51 -6.08 -0.35 4.2e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24261754 chr3:193310895 OPA1 0.62 6.72 0.38 1.12e-10 Gut microbiome composition (summer); CESC cis rs703842 1.000 rs6581155 chr12:58178162 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.71 9.33 0.5 4.47e-18 Multiple sclerosis; CESC cis rs4889855 0.556 rs4508465 chr17:78543368 G/A cg16591659 chr17:78472290 NA 0.38 6.32 0.36 1.08e-9 Fractional excretion of uric acid; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23486179 chr3:49466665 NICN1 -0.47 -6.2 -0.36 2.19e-9 Fibrinogen levels; CESC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg18876405 chr7:65276391 NA 0.51 7.02 0.4 1.9e-11 Aortic root size; CESC cis rs9911578 0.967 rs12603238 chr17:57130785 C/T cg05425664 chr17:57184151 TRIM37 0.53 7.36 0.41 2.26e-12 Intelligence (multi-trait analysis); CESC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg07691484 chr11:842764 TSPAN4;POLR2L -0.7 -9.75 -0.51 2.1e-19 Mean platelet volume; CESC cis rs6460942 0.915 rs72584550 chr7:12304990 G/A cg06484146 chr7:12443880 VWDE -0.4 -5.59 -0.32 5.57e-8 Coronary artery disease; CESC cis rs1451375 0.617 rs880029 chr7:50569927 G/C cg14593290 chr7:50529359 DDC -0.53 -6.67 -0.38 1.48e-10 Malaria; CESC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg17372223 chr3:52568218 NT5DC2 0.42 6.34 0.36 1e-9 Intelligence (multi-trait analysis); CESC cis rs7647973 1.000 rs6805609 chr3:49471522 C/G cg06212747 chr3:49208901 KLHDC8B -0.55 -6.45 -0.37 5.2400000000000005e-10 Menarche (age at onset); CESC cis rs72781680 0.898 rs72780191 chr2:24007122 T/C cg08917208 chr2:24149416 ATAD2B 1.13 10.18 0.53 9.42e-21 Lymphocyte counts; CESC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg00149659 chr3:10157352 C3orf10 0.62 7.37 0.41 2.2e-12 Alzheimer's disease; CESC cis rs8067545 1.000 rs8065337 chr17:19941879 C/A cg13482628 chr17:19912719 NA 0.43 5.72 0.33 2.9e-8 Schizophrenia; CESC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg02569458 chr12:86230093 RASSF9 0.49 7.22 0.41 5.67e-12 Major depressive disorder; CESC cis rs4077515 0.935 rs3088081 chr9:139270149 A/G cg14169450 chr9:139327907 INPP5E 0.41 5.88 0.34 1.24e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07925619 chr17:39913753 JUP 0.44 6.0 0.35 6.58e-9 Fibrinogen levels; CESC cis rs7246657 1.000 rs34544865 chr19:37801242 G/C cg23950597 chr19:37808831 NA -0.63 -5.85 -0.34 1.47e-8 Coronary artery calcification; CESC cis rs12956009 0.518 rs10164267 chr18:44820032 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.45 -5.95 -0.34 8.24e-9 Educational attainment (years of education); CESC cis rs4746818 0.793 rs2008541 chr10:70860599 A/G cg11621586 chr10:70884670 VPS26A 0.83 8.65 0.47 5.14e-16 Left atrial antero-posterior diameter; CESC cis rs11711311 1.000 rs13061150 chr3:113506734 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.59 7.83 0.43 1.14e-13 IgG glycosylation; CESC cis rs72781680 0.559 rs72796103 chr2:23900382 G/A cg08917208 chr2:24149416 ATAD2B 1.17 10.72 0.55 1.61e-22 Lymphocyte counts; CESC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 4.97e-9 Prudent dietary pattern; CESC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg17971929 chr21:40555470 PSMG1 1.01 13.92 0.65 1.92e-33 Cognitive function; CESC cis rs3762318 1.000 rs3762318 chr1:67597119 A/G cg17031739 chr1:67600172 NA -0.55 -6.21 -0.36 2.07e-9 Leprosy; CESC cis rs524281 0.861 rs11227409 chr11:65870938 A/G cg14036092 chr11:66035641 RAB1B -0.62 -6.29 -0.36 1.27e-9 Electroencephalogram traits; CESC cis rs2658782 0.789 rs3019206 chr11:93111073 A/G cg15737290 chr11:93063684 CCDC67 0.52 6.73 0.38 1.04e-10 Pulmonary function decline; CESC cis rs7296418 0.961 rs4148863 chr12:123569375 A/G cg05973401 chr12:123451056 ABCB9 0.59 7.84 0.43 1.12e-13 Platelet count; CESC cis rs9549367 0.713 rs556990 chr13:113845059 T/C cg00898013 chr13:113819073 PROZ 0.46 6.89 0.39 4.03e-11 Platelet distribution width; CESC trans rs1908814 0.516 rs35391955 chr8:11796728 A/C cg15556689 chr8:8085844 FLJ10661 0.52 6.44 0.37 5.68e-10 Neuroticism; CESC cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg02297831 chr4:17616191 MED28 0.51 6.18 0.35 2.44e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2836974 0.830 rs2735309 chr21:40715313 C/T cg11644478 chr21:40555479 PSMG1 0.93 13.51 0.64 5.27e-32 Cognitive function; CESC cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg07636037 chr3:49044803 WDR6 0.99 18.11 0.74 3.06e-48 Parkinson's disease; CESC cis rs12474201 0.507 rs6714451 chr2:47017743 G/C cg06386533 chr2:46925753 SOCS5 0.48 6.29 0.36 1.3e-9 Height; CESC trans rs1814175 0.645 rs1874969 chr11:49826700 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -6.25 -0.36 1.64e-9 Height; CESC cis rs5758659 1.000 rs134900 chr22:42683343 C/G cg05082376 chr22:42548792 NA -0.36 -5.51 -0.32 8.44e-8 Cognitive function; CESC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg20243544 chr17:37824526 PNMT 0.5 6.37 0.36 8.22e-10 Glomerular filtration rate (creatinine); CESC cis rs2016266 0.859 rs10783575 chr12:53742885 C/T cg26875137 chr12:53738046 NA -0.37 -5.49 -0.32 9.17e-8 Bone mineral density (spine);Bone mineral density; CESC cis rs7772486 0.875 rs6570738 chr6:146412695 G/A cg05347473 chr6:146136440 FBXO30 0.5 6.87 0.39 4.66e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4253772 0.591 rs739165 chr22:46684528 C/T cg24881330 chr22:46731750 TRMU 0.77 5.78 0.33 2.15e-8 LDL cholesterol;Cholesterol, total; CESC cis rs524281 0.861 rs6591208 chr11:65949689 A/C cg14036092 chr11:66035641 RAB1B -0.58 -5.91 -0.34 1.07e-8 Electroencephalogram traits; CESC cis rs2249625 0.874 rs2463745 chr6:72876135 A/G cg18830697 chr6:72922368 RIMS1 -0.4 -5.86 -0.34 1.36e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs12579753 1.000 rs17749267 chr12:82178308 A/G cg23701643 chr12:82153290 PPFIA2 0.37 5.14 0.3 5.44e-7 Resting heart rate; CESC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg08109568 chr15:31115862 NA -0.72 -9.73 -0.51 2.44e-19 Huntington's disease progression; CESC cis rs722599 0.715 rs11851433 chr14:75339450 C/T cg08847533 chr14:75593920 NEK9 0.47 6.02 0.35 5.74e-9 IgG glycosylation; CESC cis rs9596863 1.000 rs9591538 chr13:54407573 A/C ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs17608059 0.679 rs9898056 chr17:13951966 C/G cg27005118 chr17:13972210 COX10 -0.37 -5.62 -0.33 4.93e-8 Temperament; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24434368 chr7:116593263 ST7;ST7OT4;ST7OT1 -0.58 -7.04 -0.4 1.64e-11 Gut microbiome composition (summer); CESC trans rs10411161 0.702 rs892039 chr19:52396541 G/A cg22319618 chr22:45562946 NUP50 -0.77 -7.77 -0.43 1.78e-13 Breast cancer; CESC cis rs2273669 0.667 rs75671532 chr6:109341298 A/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC trans rs79976124 0.837 rs11751994 chr6:66644028 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 8.26 0.45 6.99e-15 Type 2 diabetes; CESC cis rs9911578 0.967 rs6503893 chr17:57149695 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.06 0.3 8.02e-7 Intelligence (multi-trait analysis); CESC cis rs71327718 1 rs71327718 chr3:125592857 C/G cg05084668 chr3:125655381 ALG1L -0.77 -7.79 -0.43 1.55e-13 Metabolite levels (HVA/5-HIAA ratio); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22610194 chr7:77045539 PION 0.57 6.18 0.35 2.45e-9 Gut microbiome composition (summer); CESC cis rs11214589 0.774 rs7107223 chr11:113255574 A/T cg14159747 chr11:113255604 NA 0.37 6.88 0.39 4.2e-11 Neuroticism; CESC cis rs1707322 1.000 rs12403666 chr1:46431621 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.67 0.33 3.8e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg24879335 chr3:133465180 TF -0.31 -5.05 -0.3 8.16e-7 Iron status biomarkers; CESC cis rs10463316 0.747 rs10077700 chr5:150768324 A/T cg03212797 chr5:150827313 SLC36A1 -0.45 -5.88 -0.34 1.24e-8 Metabolite levels (Pyroglutamine); CESC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.65 9.04 0.49 3.33e-17 Menopause (age at onset); CESC cis rs8141529 0.664 rs5762861 chr22:29250505 T/G cg02153584 chr22:29168773 CCDC117 0.52 6.47 0.37 4.59e-10 Lymphocyte counts; CESC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg07677032 chr17:61819896 STRADA 0.45 5.96 0.34 8.19e-9 Prudent dietary pattern; CESC cis rs854765 0.547 rs2955359 chr17:17946730 T/C cg09796270 chr17:17721594 SREBF1 -0.38 -5.07 -0.3 7.66e-7 Total body bone mineral density; CESC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.89 0.34 1.18e-8 Electroencephalogram traits; CESC cis rs1538970 0.884 rs61788261 chr1:45899114 G/A cg03146154 chr1:46216737 IPP 0.44 5.11 0.3 6.13e-7 Platelet count; CESC cis rs4065321 0.522 rs3744245 chr17:38146542 C/G cg17467752 chr17:38218738 THRA -0.45 -5.91 -0.34 1.04e-8 White blood cell count (basophil);White blood cell count; CESC cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg19539972 chr4:7069911 GRPEL1 -0.76 -7.49 -0.42 9.98e-13 Monocyte percentage of white cells; CESC cis rs11711311 1.000 rs10212375 chr3:113471336 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.59 7.81 0.43 1.33e-13 IgG glycosylation; CESC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.35 -0.31 1.89e-7 Total body bone mineral density; CESC cis rs7071206 0.853 rs57420220 chr10:79428886 C/T cg23888215 chr10:79422304 NA -0.53 -5.68 -0.33 3.5e-8 Bone mineral density; CESC cis rs1395 0.744 rs62130714 chr2:27532870 A/G cg22903471 chr2:27725779 GCKR -0.48 -5.74 -0.33 2.57e-8 Blood metabolite levels; CESC cis rs6714710 0.603 rs717417 chr2:98416850 T/G cg26665480 chr2:98280029 ACTR1B 0.68 9.4 0.5 2.59e-18 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs2404602 0.692 rs35195096 chr15:76938447 C/T cg22467129 chr15:76604101 ETFA -0.35 -5.21 -0.3 3.89e-7 Blood metabolite levels; CESC cis rs1559088 0.895 rs7246562 chr19:33546088 T/G cg17764715 chr19:33622953 WDR88 0.5 6.04 0.35 5.08e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7188697 0.922 rs246258 chr16:58579274 A/G cg02549819 chr16:58548995 SETD6 0.4 5.03 0.3 8.98e-7 QT interval; CESC cis rs6500395 1.000 rs11076578 chr16:48714520 C/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9457247 0.967 rs376097 chr6:167410878 A/G cg25258033 chr6:167368657 RNASET2 0.4 6.14 0.35 2.93e-9 Crohn's disease; CESC cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg05343316 chr1:45956843 TESK2 -0.51 -6.5 -0.37 3.93e-10 High light scatter reticulocyte count; CESC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg04944784 chr2:26401820 FAM59B 0.96 10.55 0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs9379850 0.527 rs9393704 chr6:26358775 T/C cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.52e-7 Intelligence (multi-trait analysis); CESC cis rs2354432 0.607 rs7516430 chr1:146767062 A/G cg25205988 chr1:146714368 CHD1L -0.96 -10.35 -0.54 2.56e-21 Mitochondrial DNA levels; CESC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg21951975 chr1:209979733 IRF6 0.53 8.71 0.47 3.44e-16 Cleft lip with or without cleft palate; CESC cis rs6570726 1.000 rs374464 chr6:145846679 A/C cg23711669 chr6:146136114 FBXO30 0.76 11.22 0.57 3.63e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs595982 0.527 rs73061656 chr19:49372355 G/A cg15549821 chr19:49342101 PLEKHA4 -0.65 -6.96 -0.39 2.63e-11 Red cell distribution width; CESC cis rs4423214 0.840 rs1790344 chr11:71176897 A/G cg05163923 chr11:71159392 DHCR7 -0.65 -7.55 -0.42 6.91e-13 Vitamin D levels; CESC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.41 -5.26 -0.31 2.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2573652 1.000 rs2573650 chr15:100514097 A/G cg00587665 chr15:100533223 ADAMTS17 0.32 5.05 0.3 8.08e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17446216 chr1:32480239 KHDRBS1 -0.58 -7.22 -0.41 5.64e-12 Gut microbiome composition (summer); CESC cis rs3820068 0.581 rs72645889 chr1:15930251 T/G cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs3859192 0.599 rs2270401 chr17:38176256 A/T cg17467752 chr17:38218738 THRA -0.44 -5.8 -0.34 1.93e-8 White blood cell count; CESC cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg11812906 chr14:75593930 NEK9 -0.84 -13.95 -0.65 1.57e-33 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15309264 chr2:58274034 VRK2 0.48 6.13 0.35 3.2e-9 Gut microbiota (bacterial taxa); CESC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg19717773 chr7:2847554 GNA12 -0.63 -10.09 -0.53 1.75e-20 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs501120 0.657 rs646890 chr10:44741710 C/T cg09554077 chr10:44749378 NA 0.43 5.19 0.3 4.27e-7 Coronary artery disease;Coronary heart disease; CESC cis rs367615 0.512 rs246105 chr5:108672946 C/T cg17395555 chr5:108820864 NA 0.48 7.88 0.44 8.54e-14 Colorectal cancer (SNP x SNP interaction); CESC cis rs9560113 0.509 rs4771758 chr13:112201573 C/G cg10483660 chr13:112241077 NA 0.42 7.19 0.4 6.68e-12 Menarche (age at onset); CESC cis rs6570726 0.935 rs401888 chr6:145831535 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2073300 0.609 rs6137929 chr20:23376357 G/A cg16736954 chr20:23401023 NAPB 0.8 6.25 0.36 1.67e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1957429 0.634 rs7143541 chr14:65419777 G/T cg23373153 chr14:65346875 NA -0.78 -7.97 -0.44 4.89e-14 Pediatric areal bone mineral density (radius); CESC cis rs6582630 0.622 rs11182005 chr12:38441292 G/A cg26384229 chr12:38710491 ALG10B -0.44 -5.95 -0.34 8.28e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs5753037 0.676 rs737945 chr22:30202774 G/C cg01021169 chr22:30184971 ASCC2 -0.46 -6.44 -0.37 5.61e-10 Type 1 diabetes; CESC cis rs7084402 0.967 rs1427199 chr10:60274941 C/T cg07615347 chr10:60278583 BICC1 -0.57 -8.96 -0.48 6.01e-17 Refractive error; CESC cis rs9457247 1.000 rs422562 chr6:167406318 A/G cg07741184 chr6:167504864 NA 0.31 5.59 0.33 5.5e-8 Crohn's disease; CESC cis rs9388451 0.839 rs9401845 chr6:126104118 A/G cg05901451 chr6:126070800 HEY2 -0.63 -9.23 -0.49 8.85e-18 Brugada syndrome; CESC trans rs116095464 0.558 rs7725227 chr5:233517 G/A cg00938859 chr5:1591904 SDHAP3 0.64 7.04 0.4 1.68e-11 Breast cancer; CESC cis rs992157 0.835 rs2271543 chr2:219142491 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.67 -8.69 -0.47 3.72e-16 Colorectal cancer; CESC cis rs6964587 0.900 rs7783674 chr7:91784212 T/A cg17063962 chr7:91808500 NA 0.58 8.19 0.45 1.13e-14 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27326469 chr22:47133964 CERK 0.56 6.65 0.38 1.63e-10 Gut microbiome composition (summer); CESC cis rs9322193 0.567 rs7747457 chr6:150213502 T/A cg09699651 chr6:150184138 LRP11 0.54 7.44 0.42 1.38e-12 Lung cancer; CESC trans rs11098499 0.754 rs28643450 chr4:120245242 G/A cg25214090 chr10:38739885 LOC399744 0.62 8.71 0.47 3.41e-16 Corneal astigmatism; CESC cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg11742103 chr11:62369870 EML3;MTA2 0.64 9.7 0.51 3.09e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs4330281 0.740 rs4611850 chr3:17798649 A/C cg20981856 chr3:17787350 NA 0.36 5.36 0.31 1.81e-7 Schizophrenia; CESC cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg12927641 chr6:109611667 NA -0.43 -6.78 -0.38 7.62e-11 Reticulocyte fraction of red cells; CESC cis rs12926788 0.689 rs7186308 chr16:24848471 A/G cg00339695 chr16:24857497 SLC5A11 0.52 6.85 0.39 5.05e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg11366901 chr6:160182831 ACAT2 0.82 10.61 0.55 3.82e-22 Age-related macular degeneration (geographic atrophy); CESC cis rs2735413 0.914 rs2707604 chr16:78054853 A/G cg04733911 chr16:78082701 NA -0.44 -6.58 -0.37 2.44e-10 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7605827 0.930 rs7601661 chr2:15597409 A/G cg19274914 chr2:15703543 NA 0.32 5.67 0.33 3.71e-8 Educational attainment (years of education); CESC cis rs1707322 1.000 rs4074225 chr1:46392364 G/C cg05343316 chr1:45956843 TESK2 0.5 6.13 0.35 3.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18509271 chr14:77494952 C14orf4 0.58 6.22 0.36 1.95e-9 Gut microbiome composition (summer); CESC cis rs1983170 0.736 rs745731 chr1:92011467 G/T cg02896835 chr1:92012615 NA 0.59 6.22 0.36 1.88e-9 Eosinophil percentage of white cells; CESC cis rs7726839 0.540 rs7434 chr5:660804 A/G cg16447950 chr5:562315 NA 0.61 6.66 0.38 1.57e-10 Obesity-related traits; CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.37 -5.41 -0.32 1.39e-7 Electroencephalogram traits; CESC cis rs12142240 0.698 rs12385696 chr1:46818836 A/G cg10495392 chr1:46806563 NSUN4 0.56 6.22 0.36 1.93e-9 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10880863 chr7:132937862 EXOC4 0.47 6.11 0.35 3.57e-9 Gut microbiota (bacterial taxa); CESC cis rs12479064 0.724 rs112900993 chr2:99948805 C/G cg09787394 chr2:99771194 LIPT1;TSGA10 0.48 5.06 0.3 7.78e-7 Chronic sinus infection; CESC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.26 0.31 3e-7 Menopause (age at onset); CESC cis rs2415984 0.579 rs8010773 chr14:46956863 T/C cg14871534 chr14:47121158 RPL10L -0.36 -5.45 -0.32 1.15e-7 Number of children ever born; CESC cis rs4604732 0.631 rs1106719 chr1:247624713 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 -0.5 -6.44 -0.37 5.56e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9611565 0.559 rs7290991 chr22:41964361 C/G cg17376030 chr22:41985996 PMM1 0.53 5.88 0.34 1.25e-8 Vitiligo; CESC cis rs1707322 0.752 rs11211146 chr1:46109794 T/C cg03146154 chr1:46216737 IPP 0.82 11.48 0.58 5.01e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7107174 1.000 rs2511187 chr11:77985849 T/A cg02023728 chr11:77925099 USP35 0.47 6.49 0.37 4.19e-10 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15606692 chr11:124669480 C11orf61 -0.59 -7.1 -0.4 1.15e-11 Gut microbiome composition (summer); CESC cis rs7071206 0.947 rs10509391 chr10:79422369 G/A cg00983440 chr10:79422392 NA -0.69 -8.22 -0.45 9.07e-15 Bone mineral density; CESC cis rs17854409 0.764 rs12625513 chr20:61475661 G/A cg07645718 chr20:61493192 TCFL5 0.94 5.03 0.3 9.14e-7 Obesity-related traits; CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg11639397 chr19:46010716 VASP 0.59 6.44 0.37 5.63e-10 Endometrial cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01248421 chr18:32924572 ZNF24 -0.6 -7.08 -0.4 1.32e-11 Gut microbiome composition (summer); CESC cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg24733560 chr20:60626293 TAF4 0.44 6.57 0.37 2.65e-10 Body mass index; CESC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.41e-28 Prudent dietary pattern; CESC cis rs2985684 0.846 rs10150624 chr14:50051565 A/G cg04989706 chr14:50066350 PPIL5 -0.45 -5.05 -0.3 8.24e-7 Carotid intima media thickness; CESC cis rs2204008 0.652 rs11520002 chr12:38022179 G/T cg13010199 chr12:38710504 ALG10B 0.54 6.63 0.38 1.87e-10 Bladder cancer; CESC cis rs1425132 0.805 rs718015 chr7:37563478 G/T cg15028436 chr7:37888078 TXNDC3 -0.31 -5.2 -0.3 4.09e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin); CESC cis rs722599 0.748 rs3742783 chr14:75377008 C/T cg08847533 chr14:75593920 NEK9 -0.45 -5.37 -0.31 1.72e-7 IgG glycosylation; CESC cis rs7267979 1.000 rs7018 chr20:25278261 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.85 16.94 0.72 3.97e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs68170813 0.559 rs7779062 chr7:106880195 T/A cg02696742 chr7:106810147 HBP1 -0.52 -5.13 -0.3 5.57e-7 Coronary artery disease; CESC cis rs17431357 0.867 rs117548673 chr12:120968889 G/A cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs854765 0.583 rs11650649 chr17:17790319 C/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.48 -6.2 -0.36 2.14e-9 Total body bone mineral density; CESC cis rs1348850 0.634 rs1534304 chr2:178489264 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 5.37 0.31 1.74e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7772486 0.875 rs854145 chr6:146349650 C/T cg05347473 chr6:146136440 FBXO30 0.48 6.27 0.36 1.46e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs757110 0.866 rs5215 chr11:17408630 C/T cg01153817 chr11:17409509 KCNJ11 0.35 5.1 0.3 6.53e-7 Type 2 diabetes; CESC cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg27398817 chr8:82754497 SNX16 -0.42 -5.32 -0.31 2.24e-7 Diastolic blood pressure; CESC cis rs4243830 0.850 rs4908558 chr1:6584101 A/G cg05709478 chr1:6581295 PLEKHG5 -0.47 -5.17 -0.3 4.72e-7 Body mass index; CESC cis rs1003719 0.680 rs2187577 chr21:38533341 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.94 -0.44 5.62e-14 Eye color traits; CESC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.67 6.51 0.37 3.73e-10 LDL cholesterol;Cholesterol, total; CESC cis rs5758659 0.714 rs6002626 chr22:42517989 C/G cg04733989 chr22:42467013 NAGA -0.4 -5.41 -0.32 1.39e-7 Cognitive function; CESC cis rs1348850 0.914 rs10497503 chr2:178371739 G/T cg23306229 chr2:178417860 TTC30B 0.67 8.82 0.48 1.59e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg11663144 chr21:46675770 NA -0.49 -6.62 -0.38 1.99e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg07648498 chr16:89883185 FANCA 0.49 6.21 0.36 2.01e-9 Vitiligo; CESC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg12648201 chr2:27665141 KRTCAP3 -0.33 -6.09 -0.35 3.86e-9 Total body bone mineral density; CESC cis rs11098499 0.955 rs1397608 chr4:120161744 A/G cg24375607 chr4:120327624 NA 0.43 5.24 0.31 3.34e-7 Corneal astigmatism; CESC cis rs634534 0.622 rs531612 chr11:65705432 C/T cg26695010 chr11:65641043 EFEMP2 0.47 5.9 0.34 1.12e-8 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg25405998 chr7:65216604 CCT6P1 0.49 5.26 0.31 2.97e-7 Aortic root size; CESC trans rs3942852 0.568 rs10769313 chr11:48097466 A/G cg15704280 chr7:45808275 SEPT13 -0.72 -9.39 -0.5 2.86e-18 Acute lymphoblastic leukemia (childhood); CESC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg22823121 chr1:150693482 HORMAD1 0.36 5.12 0.3 5.88e-7 Melanoma; CESC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg12463550 chr7:65579703 CRCP 0.49 6.35 0.36 9.51e-10 Aortic root size; CESC cis rs727563 0.594 rs5758408 chr22:42077737 A/C cg06481639 chr22:41940642 POLR3H 0.57 5.74 0.33 2.58e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg02931644 chr1:25747376 RHCE 0.38 6.37 0.36 8.43e-10 Plateletcrit;Mean corpuscular volume; CESC cis rs9921192 0.967 rs3747571 chr16:4323983 A/G cg00021532 chr16:4324280 TFAP4 0.9 13.94 0.65 1.69e-33 Prostate-specific antigen levels; CESC cis rs5498 0.869 rs2569702 chr19:10403947 A/G cg08845333 chr19:10403403 ICAM5 0.4 5.51 0.32 8.48e-8 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs7666738 0.716 rs35195511 chr4:98859660 G/A cg03467027 chr4:99064603 C4orf37 0.42 5.17 0.3 4.56e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7772486 0.840 rs2474355 chr6:146312540 C/G cg23711669 chr6:146136114 FBXO30 0.9 13.07 0.63 1.79e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs2953145 0.568 rs2975752 chr2:241521327 A/G cg07929629 chr2:241523174 NA 0.57 7.23 0.41 5.03e-12 Bipolar disorder; CESC cis rs7666738 0.830 rs6819047 chr4:98866902 G/A cg17366294 chr4:99064904 C4orf37 0.55 7.72 0.43 2.38e-13 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.77 -9.88 -0.52 8.65e-20 Alzheimer's disease; CESC cis rs1348850 0.668 rs12618542 chr2:178494520 A/G cg22681709 chr2:178499509 PDE11A -0.46 -6.28 -0.36 1.41e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs636291 0.517 rs11121579 chr1:10541824 G/C cg07384165 chr1:10488281 NA -0.58 -8.51 -0.46 1.33e-15 Prostate cancer; CESC cis rs4700695 0.668 rs253214 chr5:65499401 A/G cg21114390 chr5:65439923 SFRS12 -0.49 -5.98 -0.34 7.07e-9 Facial morphology (factor 19); CESC cis rs7474896 0.559 rs1208779 chr10:38077729 A/C cg25427524 chr10:38739819 LOC399744 -0.47 -5.24 -0.31 3.34e-7 Obesity (extreme); CESC cis rs921968 0.612 rs496908 chr2:219357742 A/T cg02176678 chr2:219576539 TTLL4 0.44 7.69 0.43 2.92e-13 Mean corpuscular hemoglobin concentration; CESC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg27170947 chr2:26402098 FAM59B -0.59 -7.1 -0.4 1.13e-11 Gut microbiome composition (summer); CESC cis rs3806933 0.522 rs12515367 chr5:110447853 A/G cg04022379 chr5:110408740 TSLP 0.46 7.39 0.41 1.98e-12 Eosinophilic esophagitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04267851 chr20:377134 TRIB3 0.47 6.8 0.39 6.93e-11 Fibrinogen levels; CESC cis rs2274273 1.000 rs3742566 chr14:55595839 T/A cg04306507 chr14:55594613 LGALS3 0.28 5.28 0.31 2.63e-7 Protein biomarker; CESC trans rs6089829 0.962 rs6062777 chr20:61663748 G/A cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg09323728 chr8:95962352 TP53INP1 -0.26 -5.09 -0.3 6.67e-7 Type 2 diabetes; CESC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.48 -6.39 -0.37 7.49e-10 Personality dimensions; CESC trans rs13098911 0.540 rs34324101 chr3:46000728 T/G cg10236987 chr1:228114221 WNT9A 0.57 6.07 0.35 4.38e-9 Celiac disease; CESC cis rs11577318 0.796 rs4625269 chr1:26626967 C/A cg19743891 chr1:26644573 UBXN11;CD52 -0.28 -5.11 -0.3 6.05e-7 Granulocyte percentage of myeloid white cells; CESC cis rs34779708 0.966 rs7070427 chr10:35485689 A/T cg04310649 chr10:35416472 CREM -0.52 -6.34 -0.36 9.86e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs8060686 0.641 rs36086450 chr16:68046996 A/C cg26727032 chr16:67993705 SLC12A4 -0.54 -6.15 -0.35 2.78e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs35110281 0.712 rs1454648 chr21:45053815 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 7.08 0.4 1.32e-11 Mean corpuscular volume; CESC cis rs858239 0.600 rs28646184 chr7:23139595 T/C cg23682824 chr7:23144976 KLHL7 0.55 7.73 0.43 2.23e-13 Cerebrospinal fluid biomarker levels; CESC cis rs6831352 0.918 rs2851249 chr4:100044822 T/C cg13256891 chr4:100009986 ADH5 0.74 8.21 0.45 9.57e-15 Alcohol dependence; CESC cis rs3126085 0.877 rs4845742 chr1:152183949 G/A cg03465714 chr1:152285911 FLG -0.43 -5.16 -0.3 4.81e-7 Atopic dermatitis; CESC cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg24110177 chr3:50126178 RBM5 0.52 6.99 0.39 2.2e-11 Body mass index; CESC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg00149659 chr3:10157352 C3orf10 -0.73 -9.15 -0.49 1.59e-17 Alzheimer's disease; CESC cis rs7980687 0.574 rs10744149 chr12:123708490 T/A cg00376283 chr12:123451042 ABCB9 0.68 8.46 0.46 1.81e-15 Height;Educational attainment;Head circumference (infant); CESC cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg27028030 chr7:100209634 MOSPD3 0.56 5.49 0.32 9.51e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs854765 0.583 rs6502619 chr17:17779704 C/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.49 -6.26 -0.36 1.58e-9 Total body bone mineral density; CESC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg23803603 chr1:2058230 PRKCZ -0.31 -5.25 -0.31 3.14e-7 Height; CESC cis rs9788682 0.747 rs8042374 chr15:78908032 A/G cg24631222 chr15:78858424 CHRNA5 0.78 9.59 0.51 6.67e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs2832077 0.506 rs2832081 chr21:30152992 A/C cg24692254 chr21:30365293 RNF160 0.5 6.13 0.35 3.22e-9 Cognitive test performance; CESC cis rs7617480 0.648 rs4974083 chr3:49000626 A/G cg06212747 chr3:49208901 KLHDC8B 0.49 5.34 0.31 1.99e-7 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs4555082 0.834 rs2735819 chr14:105713449 C/T cg06808227 chr14:105710500 BRF1 -0.51 -5.78 -0.33 2.13e-8 Mean platelet volume;Platelet distribution width; CESC cis rs920590 0.721 rs67989257 chr8:19660278 G/A cg03894339 chr8:19674705 INTS10 0.64 7.31 0.41 3.24e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs2710642 0.721 rs12328837 chr2:62896544 G/A cg17519650 chr2:63277830 OTX1 0.57 7.06 0.4 1.46e-11 LDL cholesterol levels;LDL cholesterol; CESC cis rs11645898 0.748 rs72787042 chr16:72067522 A/G cg14768367 chr16:72042858 DHODH -0.84 -6.92 -0.39 3.43e-11 Blood protein levels; CESC cis rs17125944 0.686 rs7149638 chr14:53346931 T/C cg00686598 chr14:53173677 PSMC6 -0.61 -5.36 -0.31 1.84e-7 Alzheimer's disease (late onset); CESC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg09699651 chr6:150184138 LRP11 0.4 5.04 0.3 8.58e-7 Lung cancer; CESC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.58 5.69 0.33 3.34e-8 Cerebrospinal P-tau181p levels; CESC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg08027265 chr7:2291960 NA -0.48 -7.49 -0.42 1.04e-12 Bipolar disorder and schizophrenia; CESC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg23758822 chr17:41437982 NA 1.03 14.77 0.67 2.05e-36 Menopause (age at onset); CESC trans rs9325144 0.555 rs7968322 chr12:38792348 T/C cg23762105 chr12:34175262 ALG10 0.46 6.09 0.35 4e-9 Morning vs. evening chronotype; CESC cis rs938554 0.612 rs7669607 chr4:9997801 C/T cg00071950 chr4:10020882 SLC2A9 -0.59 -7.38 -0.41 2.06e-12 Blood metabolite levels; CESC trans rs7615952 0.866 rs6438949 chr3:125650064 G/C cg07211511 chr3:129823064 LOC729375 -1.09 -14.38 -0.66 4.86e-35 Blood pressure (smoking interaction); CESC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.03 0.3 8.89e-7 Bipolar disorder; CESC cis rs7246865 0.510 rs34833670 chr19:17172983 T/C cg16202187 chr19:17186497 HAUS8;MYO9B 0.48 6.28 0.36 1.38e-9 Reticulocyte fraction of red cells; CESC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg26769984 chr7:1090371 C7orf50 0.54 6.18 0.35 2.47e-9 Bronchopulmonary dysplasia; CESC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg03709012 chr19:19516395 GATAD2A -0.99 -15.45 -0.69 7.62e-39 Tonsillectomy; CESC cis rs7827545 1.000 rs7832857 chr8:135565477 A/G cg17885191 chr8:135476712 NA 0.48 6.28 0.36 1.39e-9 Hypertension (SNP x SNP interaction); CESC cis rs698833 0.518 rs4953085 chr2:44554724 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.55 5.83 0.34 1.57e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs12681366 0.734 rs10102496 chr8:95398181 G/A cg13257157 chr8:95487014 RAD54B 0.38 5.14 0.3 5.22e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs9399401 0.710 rs7765770 chr6:142687305 C/T cg03128060 chr6:142623767 GPR126 0.37 6.51 0.37 3.66e-10 Chronic obstructive pulmonary disease; CESC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg05564831 chr3:52568323 NT5DC2 0.43 6.65 0.38 1.71e-10 Bipolar disorder; CESC cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.45 5.91 0.34 1.04e-8 Personality dimensions; CESC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs11155671 0.530 rs4870080 chr6:150202644 T/C cg09699651 chr6:150184138 LRP11 0.57 7.71 0.43 2.57e-13 Testicular germ cell tumor; CESC cis rs7208859 0.524 rs73263982 chr17:28920624 T/C cg17105886 chr17:28927953 LRRC37B2 0.61 5.4 0.31 1.47e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9929218 0.954 rs34097984 chr16:68824148 T/G cg02972257 chr16:68554789 NA 0.45 5.38 0.31 1.66e-7 Colorectal cancer; CESC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg24503407 chr1:205819492 PM20D1 -0.44 -6.03 -0.35 5.37e-9 Menarche (age at onset); CESC cis rs9916302 0.706 rs12950186 chr17:37393395 A/C cg07936489 chr17:37558343 FBXL20 -0.93 -10.49 -0.54 9.21e-22 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26407100 chr8:11726043 CTSB -0.59 -6.53 -0.37 3.32e-10 Gut microbiome composition (summer); CESC cis rs698813 0.674 rs7590224 chr2:44501209 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.07 0.3 7.5e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs12928939 0.517 rs10852507 chr16:71971900 G/A cg03805757 chr16:71968109 PKD1L3 -0.57 -6.49 -0.37 4.16e-10 Post bronchodilator FEV1; CESC trans rs11039798 0.511 rs2047812 chr11:48162042 A/G cg15704280 chr7:45808275 SEPT13 -0.7 -7.05 -0.4 1.52e-11 Axial length; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg02315113 chr1:173684045 KLHL20 -0.46 -6.35 -0.36 9.27e-10 Height; CESC cis rs60843830 1.000 rs7595075 chr2:264019 C/A cg25945732 chr2:264204 ACP1;SH3YL1 0.89 12.12 0.6 3.46e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg22823121 chr1:150693482 HORMAD1 0.48 7.1 0.4 1.14e-11 Tonsillectomy; CESC cis rs2243480 0.908 rs313822 chr7:65573939 G/A cg25894440 chr7:65020034 NA -0.61 -5.04 -0.3 8.52e-7 Diabetic kidney disease; CESC cis rs9303542 0.625 rs9905940 chr17:46614102 A/C cg04904318 chr17:46607828 HOXB1 0.49 5.35 0.31 1.95e-7 Ovarian cancer;Epithelial ovarian cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14949694 chr7:66367000 NA 0.51 6.86 0.39 4.91e-11 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14702927 chr19:46366445 FOXA3;SYMPK -0.49 -6.65 -0.38 1.65e-10 Fibrinogen levels; CESC cis rs1538970 0.781 rs12049503 chr1:46021556 G/T cg03146154 chr1:46216737 IPP 0.49 5.59 0.32 5.62e-8 Platelet count; CESC cis rs870825 0.929 rs2310102 chr4:185595141 C/G cg04058563 chr4:185651563 MLF1IP -0.52 -5.15 -0.3 5.03e-7 Blood protein levels; CESC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg08470875 chr2:26401718 FAM59B -0.47 -5.24 -0.31 3.31e-7 Gut microbiome composition (summer); CESC cis rs45535039 1.000 rs3794073 chr11:119146129 T/C cg16724696 chr11:118992527 HINFP 0.43 5.42 0.32 1.31e-7 Plateletcrit; CESC cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg14784868 chr12:69753453 YEATS4 0.83 12.69 0.61 3.9e-29 Blood protein levels; CESC cis rs2933343 0.729 rs813945 chr3:128660937 A/G cg24203234 chr3:128598194 ACAD9 0.4 5.43 0.32 1.24e-7 IgG glycosylation; CESC cis rs2273669 0.667 rs12197912 chr6:109338147 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs1801251 1.000 rs6437074 chr2:233712296 C/T cg25237894 chr2:233734115 C2orf82 -0.46 -8.07 -0.44 2.53e-14 Coronary artery disease; CESC cis rs8067545 0.935 rs7209734 chr17:19988543 C/A cg13482628 chr17:19912719 NA 0.46 6.28 0.36 1.36e-9 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22690212 chr1:145438435 TXNIP -0.49 -6.46 -0.37 5.07e-10 Fibrinogen levels; CESC cis rs117623576 0.590 rs2988084 chr10:32398653 C/T cg03047570 chr10:32398778 NA 0.4 5.26 0.31 2.98e-7 Anti-saccade response; CESC cis rs13082711 0.516 rs13084067 chr3:27358935 A/T cg02860705 chr3:27208620 NA 0.57 6.92 0.39 3.44e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs12545109 0.613 rs6998873 chr8:57299697 A/G cg09654669 chr8:57350985 NA 0.56 6.42 0.37 6.14e-10 Obesity-related traits; CESC cis rs2242194 0.844 rs11264295 chr1:154987526 C/T cg06221963 chr1:154839813 KCNN3 -0.37 -5.41 -0.32 1.38e-7 Schizophrenia; CESC cis rs2635047 0.542 rs2668768 chr18:44783447 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.32 5.06 0.3 7.93e-7 Educational attainment; CESC cis rs28830936 0.510 rs2412640 chr15:42124082 C/T cg17847044 chr15:42102381 MAPKBP1 0.41 6.82 0.39 6.21e-11 Diastolic blood pressure; CESC cis rs7917772 0.536 rs17783771 chr10:104410736 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.51 5.56 0.32 6.58e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs3741151 0.892 rs7105681 chr11:73059341 G/A cg17517138 chr11:73019481 ARHGEF17 0.63 5.32 0.31 2.18e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg19774624 chr17:42201019 HDAC5 -0.89 -14.51 -0.67 1.63e-35 Total body bone mineral density; CESC cis rs78889164 0.956 rs999503 chr19:33851730 C/T cg02272751 chr19:33882848 PEPD -0.5 -6.43 -0.37 5.81e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg20503657 chr10:835505 NA 0.74 7.62 0.42 4.46e-13 Eosinophil percentage of granulocytes; CESC cis rs2228479 0.850 rs12597296 chr16:89822331 C/T cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg18876405 chr7:65276391 NA 0.48 5.3 0.31 2.47e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11120115 chr7:98649861 SMURF1 -0.59 -6.43 -0.37 5.77e-10 Gut microbiome composition (summer); CESC cis rs2953174 1.000 rs2975754 chr2:241522634 G/A cg07929629 chr2:241523174 NA 0.63 6.11 0.35 3.49e-9 Bipolar disorder; CESC cis rs854765 0.647 rs854814 chr17:18003648 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.62 8.83 0.48 1.51e-16 Total body bone mineral density; CESC cis rs17095355 1.000 rs11194920 chr10:111695412 G/T cg00817464 chr10:111662876 XPNPEP1 -0.45 -5.25 -0.31 3.18e-7 Biliary atresia; CESC cis rs7107174 1.000 rs10899476 chr11:78051794 A/G cg02023728 chr11:77925099 USP35 0.47 6.23 0.36 1.82e-9 Testicular germ cell tumor; CESC trans rs17685 0.593 rs56265719 chr7:75796269 C/T cg19862616 chr7:65841803 NCRNA00174 0.79 11.08 0.56 1.09e-23 Coffee consumption;Coffee consumption (cups per day); CESC cis rs10392 0.516 rs4141892 chr20:37590758 T/C cg27552599 chr20:37590471 DHX35 0.38 5.76 0.33 2.37e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs6500395 0.775 rs8050844 chr16:48665696 A/G cg04672837 chr16:48644449 N4BP1 0.49 6.27 0.36 1.46e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24937796 chr17:45918691 SCRN2 0.59 6.54 0.37 3.15e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01382281 chr19:56104340 FIZ1 -0.59 -6.43 -0.37 5.94e-10 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs778729 chr7:65824419 T/C cg18252515 chr7:66147081 NA -1.39 -14.18 -0.66 2.5e-34 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01604348 chr19:54663591 LENG1 -0.56 -6.43 -0.37 5.99e-10 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs7654345 chr4:17691796 A/G cg16339924 chr4:17578868 LAP3 0.63 7.67 0.43 3.27e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs965469 0.708 rs80050989 chr20:3297881 A/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.39 -0.31 1.59e-7 IFN-related cytopenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14851846 chr7:99716985 TAF6;CNPY4 -0.4 -6.01 -0.35 6.01e-9 Gambling; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18001435 chr13:111291955 CARKD 0.53 7.73 0.43 2.21e-13 Fibrinogen levels; CESC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.07 12.72 0.62 3.02e-29 Gut microbiome composition (summer); CESC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg06634786 chr22:41940651 POLR3H -0.69 -6.78 -0.38 7.77e-11 Vitiligo; CESC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg04944784 chr2:26401820 FAM59B 0.96 10.83 0.55 7.34e-23 Gut microbiome composition (summer); CESC cis rs8017423 0.647 rs10132599 chr14:90815342 C/T cg14092571 chr14:90743983 NA 0.43 6.62 0.38 1.93e-10 Mortality in heart failure; CESC cis rs12586317 0.620 rs76293361 chr14:35570889 G/A cg16230307 chr14:35515116 FAM177A1 0.92 9.84 0.52 1.12e-19 Psoriasis; CESC cis rs1707322 0.716 rs28370457 chr1:46172062 C/T cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7202877 0.610 rs8053632 chr16:75364940 C/T cg04384234 chr16:75411784 CFDP1 -0.45 -5.37 -0.31 1.68e-7 Type 2 diabetes;Type 1 diabetes; CESC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg10053473 chr17:62856997 LRRC37A3 0.69 7.65 0.43 3.82e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs8031584 0.958 rs34909055 chr15:31284170 C/T cg14298792 chr15:30685198 CHRFAM7A -0.44 -5.23 -0.31 3.52e-7 Huntington's disease progression; CESC cis rs80282103 0.618 rs59377495 chr10:1157019 C/T cg08668510 chr10:1095578 IDI1 0.74 6.04 0.35 5.2e-9 Glomerular filtration rate (creatinine); CESC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg10691866 chr7:65817282 TPST1 0.33 5.53 0.32 7.81e-8 Aortic root size; CESC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg18252515 chr7:66147081 NA 0.39 5.2 0.3 4.09e-7 Aortic root size; CESC cis rs2204008 0.774 rs10400552 chr12:38393577 C/G cg13010199 chr12:38710504 ALG10B 0.47 5.88 0.34 1.25e-8 Bladder cancer; CESC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6e-10 Life satisfaction; CESC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg02725872 chr8:58115012 NA -0.42 -5.74 -0.33 2.62e-8 Developmental language disorder (linguistic errors); CESC cis rs9325144 0.647 rs7957185 chr12:38909710 G/A cg26384229 chr12:38710491 ALG10B -0.55 -7.73 -0.43 2.2e-13 Morning vs. evening chronotype; CESC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg21724239 chr8:58056113 NA -0.59 -5.9 -0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs854765 0.647 rs2974999 chr17:17997547 T/G cg04398451 chr17:18023971 MYO15A -0.77 -11.4 -0.57 8.88e-25 Total body bone mineral density; CESC cis rs6537837 1.000 rs2301229 chr1:110136678 C/T cg05049280 chr1:110155535 GNAT2 0.38 5.3 0.31 2.42e-7 Major depressive disorder; CESC cis rs12900413 0.673 rs35308090 chr15:90308026 G/T cg24249390 chr15:90295951 MESP1 -0.42 -5.69 -0.33 3.37e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs2204008 0.777 rs2049130 chr12:38444837 G/A cg26384229 chr12:38710491 ALG10B 0.64 9.46 0.5 1.69e-18 Bladder cancer; CESC trans rs10841784 1.000 rs10841789 chr12:21467666 A/C cg00566759 chr18:28682345 DSC2 0.48 6.37 0.36 8.16e-10 Childhood ear infection; CESC cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg20476274 chr7:133979776 SLC35B4 0.64 9.22 0.49 9.9e-18 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15650170 chr7:150783791 AGAP3 0.61 6.84 0.39 5.39e-11 Gut microbiome composition (summer); CESC cis rs34779708 0.733 rs61449529 chr10:35543914 T/C cg03585969 chr10:35415529 CREM 0.56 6.54 0.37 3.22e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg15017067 chr4:17643749 FAM184B 0.39 5.47 0.32 1.02e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10353388 chr11:93474820 C11orf54;TAF1D 0.55 6.33 0.36 1.02e-9 Gut microbiome composition (summer); CESC cis rs9902453 1.000 rs55971458 chr17:28427016 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 7.94 0.44 5.85e-14 Coffee consumption (cups per day); CESC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.05 0.59 5.93e-27 Alzheimer's disease; CESC cis rs16854884 0.657 rs35877644 chr3:143701755 A/G cg06585982 chr3:143692056 C3orf58 0.48 6.2 0.36 2.11e-9 Economic and political preferences (feminism/equality); CESC cis rs523522 0.962 rs10744752 chr12:120900554 T/G cg12219531 chr12:120966889 COQ5 0.74 9.31 0.5 5.13e-18 High light scatter reticulocyte count; CESC cis rs7572263 0.724 rs7579275 chr2:209053080 A/C cg23998903 chr2:209048830 C2orf80 -0.39 -5.4 -0.31 1.47e-7 Glioma;Non-glioblastoma glioma; CESC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg20151795 chr6:28129481 ZNF389 0.48 6.24 0.36 1.73e-9 Depression; CESC cis rs8067545 0.750 rs11871651 chr17:19997425 T/C cg13482628 chr17:19912719 NA 0.41 5.52 0.32 7.93e-8 Schizophrenia; CESC cis rs3761847 0.500 rs10760132 chr9:123739993 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 5.16 0.3 4.86e-7 Rheumatoid arthritis; CESC cis rs910316 0.737 rs175055 chr14:75488946 T/G cg15467112 chr14:75489610 MLH3 -0.33 -5.14 -0.3 5.25e-7 Height; CESC cis rs7904368 0.707 rs12253979 chr10:16853415 T/C cg23933602 chr10:16859644 RSU1 0.74 7.11 0.4 1.05e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg11644478 chr21:40555479 PSMG1 -0.78 -11.54 -0.58 3.11e-25 Cognitive function; CESC cis rs4727027 0.933 rs28767030 chr7:148825918 T/G cg23158103 chr7:148848205 ZNF398 -0.4 -6.34 -0.36 9.68e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs11677416 1.000 rs3783559 chr2:113529837 A/G cg27083787 chr2:113543245 IL1A 0.43 5.37 0.31 1.73e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs2742234 0.590 rs2435376 chr10:43684963 A/G cg07801480 chr10:43725741 RASGEF1A 0.41 5.29 0.31 2.56e-7 Hirschsprung disease; CESC cis rs12618769 0.572 rs4851141 chr2:99112966 A/C cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs6570726 0.935 rs425717 chr6:145838620 A/T cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg23711669 chr6:146136114 FBXO30 0.8 10.85 0.55 6.3e-23 Lobe attachment (rater-scored or self-reported); CESC trans rs864643 0.678 rs500507 chr3:39534377 C/T cg21413947 chr1:165329957 NA 0.42 6.05 0.35 4.92e-9 Attention deficit hyperactivity disorder; CESC cis rs698813 0.604 rs58667148 chr2:44481443 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.38 0.31 1.62e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs8099014 0.861 rs6566974 chr18:56131156 A/G cg19312305 chr18:56117016 MIR122 -0.27 -5.27 -0.31 2.81e-7 Platelet count; CESC cis rs9359856 0.564 rs41273329 chr6:90393483 G/A cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.73 -0.33 2.7e-8 Bipolar disorder; CESC cis rs8020095 0.528 rs2319777 chr14:67810033 C/T cg19548862 chr14:67692701 FAM71D -0.45 -5.3 -0.31 2.41e-7 Depression (quantitative trait); CESC cis rs9527 0.590 rs7089680 chr10:104802071 C/T cg04362960 chr10:104952993 NT5C2 -0.42 -5.38 -0.31 1.66e-7 Arsenic metabolism; CESC cis rs2985684 0.948 rs6572592 chr14:50080871 G/A cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.47 -5.61 -0.33 5.18e-8 Carotid intima media thickness; CESC cis rs7818688 0.697 rs11781397 chr8:95974506 G/T cg16049864 chr8:95962084 TP53INP1 0.57 5.73 0.33 2.79e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs8141529 0.748 rs6519766 chr22:29269991 A/G cg15103426 chr22:29168792 CCDC117 -0.61 -8.32 -0.46 4.64e-15 Lymphocyte counts; CESC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg10560079 chr2:191398806 TMEM194B 0.5 7.11 0.4 1.08e-11 Pulse pressure; CESC cis rs17021463 0.902 rs10516950 chr4:95254730 C/T cg11021082 chr4:95130006 SMARCAD1 0.52 8.09 0.45 2.11e-14 Testicular germ cell tumor; CESC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.45 6.23 0.36 1.83e-9 Bipolar disorder; CESC cis rs3540 0.514 rs2601194 chr15:90937051 T/A cg22089800 chr15:90895588 ZNF774 0.66 8.91 0.48 8.58e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs5753618 0.504 rs9606848 chr22:31901867 G/A cg13145458 chr22:31556086 RNF185 -0.48 -5.69 -0.33 3.28e-8 Colorectal cancer; CESC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg12963246 chr6:28129442 ZNF389 0.51 7.07 0.4 1.36e-11 Depression; CESC cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg05347473 chr6:146136440 FBXO30 0.58 7.44 0.42 1.39e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.64 7.51 0.42 9.22e-13 Multiple sclerosis; CESC cis rs7091068 0.518 rs4144097 chr10:95432480 A/C cg20715218 chr10:95462985 C10orf4 0.45 5.79 0.34 1.96e-8 Urinary tract infection frequency; CESC cis rs2243480 1.000 rs2177703 chr7:65391717 C/A cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC cis rs36051895 0.632 rs62541959 chr9:5175687 G/C cg02405213 chr9:5042618 JAK2 -0.48 -5.5 -0.32 8.93e-8 Pediatric autoimmune diseases; CESC cis rs2797160 1.000 rs1578794 chr6:126015469 T/C cg05901451 chr6:126070800 HEY2 0.46 6.55 0.37 2.89e-10 Endometrial cancer; CESC cis rs9457247 1.000 rs2149090 chr6:167372764 T/C cg23791538 chr6:167370224 RNASET2 0.6 8.49 0.46 1.53e-15 Crohn's disease; CESC cis rs9303401 0.614 rs12948536 chr17:56580413 G/T cg12560992 chr17:57184187 TRIM37 0.52 5.08 0.3 7.01e-7 Cognitive test performance; CESC cis rs864537 0.584 rs7523907 chr1:167427247 A/G cg09179987 chr1:167433047 CD247 0.43 6.58 0.37 2.51e-10 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs9640161 0.658 rs74348353 chr7:150053655 C/A cg21361702 chr7:150065534 REPIN1 0.61 6.73 0.38 1.05e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs7746199 0.736 rs58616630 chr6:27474715 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 5.83 0.34 1.61e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs3793683 0.597 rs2182620 chr10:134590715 C/T cg26818010 chr10:134567672 INPP5A -0.91 -11.2 -0.57 4.4e-24 Migraine; CESC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg12463550 chr7:65579703 CRCP 0.56 7.07 0.4 1.39e-11 Aortic root size; CESC cis rs864537 0.646 rs2995091 chr1:167434277 T/C cg09179987 chr1:167433047 CD247 0.56 8.37 0.46 3.4e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs1153858 1.000 rs2467863 chr15:45641880 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.93 0.34 9.4e-9 Homoarginine levels; CESC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg19163074 chr7:65112434 INTS4L2 0.43 5.37 0.31 1.71e-7 Aortic root size; CESC cis rs4986811 1.000 rs5030172 chr11:32449274 G/C cg27409910 chr11:32454216 WT1 0.46 5.79 0.33 2.02e-8 Rubella-specific interleukin-6 secretion; CESC cis rs2952156 0.920 rs2247862 chr17:37829129 A/G cg07936489 chr17:37558343 FBXL20 -0.5 -6.1 -0.35 3.69e-9 Asthma; CESC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg26939375 chr7:64535504 NA -0.75 -10.67 -0.55 2.46e-22 Aortic root size; CESC cis rs9948 0.521 rs62156206 chr2:97357108 G/A cg01990225 chr2:97406019 LMAN2L -0.92 -7.06 -0.4 1.46e-11 Erectile dysfunction and prostate cancer treatment; CESC cis rs10504073 0.584 rs10957337 chr8:49959027 G/T cg00325661 chr8:49890786 NA 0.59 8.65 0.47 5.19e-16 Blood metabolite ratios; CESC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg25036284 chr2:26402008 FAM59B 0.86 9.4 0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs10208940 0.764 rs6546420 chr2:68799454 G/A cg12452813 chr2:68675892 NA 0.52 5.18 0.3 4.47e-7 Urate levels in lean individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05989775 chr11:2906934 CDKN1C 0.62 7.45 0.42 1.31e-12 Gut microbiome composition (summer); CESC cis rs1348850 0.608 rs2364845 chr2:178226240 T/C cg22681709 chr2:178499509 PDE11A -0.38 -5.73 -0.33 2.73e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs910316 0.503 rs12894709 chr14:75441734 G/A cg08847533 chr14:75593920 NEK9 0.75 11.51 0.58 3.86e-25 Height; CESC cis rs12541635 0.739 rs7833595 chr8:107089603 G/T cg10147462 chr8:107024639 NA -0.38 -5.44 -0.32 1.2e-7 Age of smoking initiation; CESC trans rs13160161 0.533 rs13179322 chr5:38986557 A/G cg09550024 chr10:96698366 CYP2C9 -0.46 -6.05 -0.35 5.05e-9 Obesity-related traits; CESC cis rs9388451 0.626 rs3734637 chr6:126081319 G/T cg05901451 chr6:126070800 HEY2 -0.59 -8.89 -0.48 9.86e-17 Brugada syndrome; CESC cis rs11122272 0.735 rs2491403 chr1:231511185 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg20503657 chr10:835505 NA 1.09 9.88 0.52 8.32e-20 Eosinophil percentage of granulocytes; CESC cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg11752832 chr7:134001865 SLC35B4 0.57 7.41 0.41 1.74e-12 Mean platelet volume; CESC cis rs1878931 0.858 rs3760083 chr16:3450052 C/T cg00484396 chr16:3507460 NAT15 0.38 5.92 0.34 1.02e-8 Body mass index (adult); CESC cis rs7264396 0.570 rs6060717 chr20:34544647 T/C cg17201900 chr20:34330562 RBM39 0.5 5.21 0.3 3.88e-7 Total cholesterol levels; CESC cis rs116095464 0.558 rs9654453 chr5:299621 T/C cg22496380 chr5:211416 CCDC127 -0.99 -10.2 -0.53 8.02e-21 Breast cancer; CESC cis rs722599 0.651 rs12887044 chr14:75255659 C/T cg08847533 chr14:75593920 NEK9 0.49 6.01 0.35 6.21e-9 IgG glycosylation; CESC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg13047869 chr3:10149882 C3orf24 0.4 5.03 0.3 8.89e-7 Alzheimer's disease; CESC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg09323728 chr8:95962352 TP53INP1 0.36 6.98 0.39 2.32e-11 Type 2 diabetes; CESC cis rs4930103 0.534 rs2063550 chr11:1979223 G/C cg23202291 chr11:1979235 NA 0.43 6.25 0.36 1.66e-9 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs1003719 1.000 rs1003719 chr21:38491095 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.65 8.87 0.48 1.12e-16 Eye color traits; CESC cis rs2108622 0.683 rs6512067 chr19:15982951 G/T cg13772218 chr19:15982569 NA 0.3 5.85 0.34 1.42e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC trans rs3087243 0.755 rs2162606 chr2:204705157 G/C cg01841312 chr10:38069945 NA -0.38 -6.3 -0.36 1.23e-9 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg22535103 chr8:58192502 C8orf71 -1.05 -12.98 -0.62 3.88e-30 Developmental language disorder (linguistic errors); CESC cis rs6493487 0.512 rs35114758 chr15:51371419 C/G cg02338191 chr15:51200825 AP4E1 0.58 5.42 0.32 1.35e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs250677 0.522 rs998304 chr5:148382365 C/A cg18129178 chr5:148520854 ABLIM3 -0.46 -5.14 -0.3 5.39e-7 Breast cancer; CESC cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg01475377 chr6:109611718 NA -0.42 -6.43 -0.37 6.01e-10 Reticulocyte fraction of red cells; CESC cis rs8002861 0.905 rs12430629 chr13:44415919 T/A cg14210620 chr13:44453864 C13orf31;CCDC122 -0.42 -5.41 -0.32 1.41e-7 Leprosy; CESC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg17366294 chr4:99064904 C4orf37 0.54 7.22 0.41 5.38e-12 Colonoscopy-negative controls vs population controls; CESC cis rs2380220 0.872 rs66723559 chr6:95956338 T/C cg15832292 chr6:96025679 MANEA -0.64 -5.66 -0.33 3.83e-8 Behavioural disinhibition (generation interaction); CESC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg24549020 chr5:56110836 MAP3K1 0.6 6.64 0.38 1.75e-10 Initial pursuit acceleration; CESC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg18305652 chr10:134549665 INPP5A 0.44 6.15 0.35 2.85e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs3858526 0.642 rs55732658 chr11:5894602 A/C cg05234568 chr11:5960015 NA -0.51 -6.1 -0.35 3.71e-9 DNA methylation (variation); CESC cis rs477895 1.000 rs12785488 chr11:64107521 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.61 5.03 0.3 9.08e-7 Mean platelet volume; CESC cis rs372883 0.648 rs2832296 chr21:30741454 C/T cg08807101 chr21:30365312 RNF160 -0.44 -5.14 -0.3 5.34e-7 Pancreatic cancer; CESC cis rs644148 0.902 rs12982159 chr19:44964300 C/T cg15540054 chr19:45004280 ZNF180 -0.69 -8.35 -0.46 3.86e-15 Personality dimensions; CESC cis rs11785693 0.862 rs7009771 chr8:4990189 C/T cg26367366 chr8:4980734 NA 0.63 6.29 0.36 1.33e-9 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs55728055 0.661 rs8142821 chr22:31941240 A/C cg01338084 chr22:32026380 PISD 1.26 8.11 0.45 1.91e-14 Age-related hearing impairment; CESC cis rs2425143 0.730 rs6060626 chr20:34415073 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -6.2 -0.36 2.14e-9 Blood protein levels; CESC cis rs7216064 1.000 rs56404791 chr17:65893019 T/G cg07042672 chr17:66097459 LOC651250 -0.62 -7.65 -0.43 3.74e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs72781680 0.799 rs17508218 chr2:23976536 C/T cg20701182 chr2:24300061 SF3B14 0.63 5.54 0.32 7.13e-8 Lymphocyte counts; CESC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.87 0.39 4.46e-11 Platelet count; CESC trans rs324780 0.544 rs3103500 chr12:83888032 A/G cg22140261 chr22:42466895 NAGA 0.47 6.03 0.35 5.38e-9 Vertical cup-disc ratio; CESC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg02524346 chr8:600233 NA -0.91 -6.74 -0.38 9.72e-11 IgG glycosylation; CESC cis rs6687430 0.526 rs7555790 chr1:10613167 A/G cg07384165 chr1:10488281 NA 0.47 6.64 0.38 1.74e-10 Hand grip strength; CESC cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg05340658 chr4:99064831 C4orf37 0.82 12.56 0.61 1.09e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2273669 0.667 rs74582170 chr6:109312689 C/T cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs7085104 0.700 rs6163 chr10:104596924 C/A cg15744005 chr10:104629667 AS3MT -0.35 -5.44 -0.32 1.23e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs56046484 0.871 rs12900736 chr15:85558140 C/T cg08123816 chr15:85640762 PDE8A -0.5 -5.94 -0.34 9.11e-9 Testicular germ cell tumor; CESC cis rs2342371 0.883 rs11185542 chr3:196187927 G/C cg15048948 chr3:196158458 UBXN7 -0.49 -6.52 -0.37 3.56e-10 Fat distribution (HIV); CESC cis rs752010 0.714 rs7515948 chr1:42079046 T/G cg06885757 chr1:42089581 HIVEP3 0.51 8.71 0.47 3.32e-16 Lupus nephritis in systemic lupus erythematosus; CESC cis rs10771431 0.738 rs11049697 chr12:9385339 T/C cg08997352 chr12:9597637 DDX12 -0.77 -10.22 -0.53 6.96e-21 Breast size; CESC cis rs67311347 1.000 rs13073003 chr3:40504326 C/T cg24209194 chr3:40518798 ZNF619 -0.58 -7.8 -0.43 1.41e-13 Renal cell carcinoma; CESC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg13628971 chr7:2884303 GNA12 0.61 7.63 0.42 4.13e-13 Height; CESC cis rs5769765 0.908 rs9616211 chr22:50317676 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.63 -6.44 -0.37 5.53e-10 Schizophrenia; CESC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 11.99 0.59 9.47e-27 Platelet count; CESC cis rs11785400 0.793 rs7000765 chr8:143722457 G/A cg24634471 chr8:143751801 JRK 0.41 5.13 0.3 5.59e-7 Schizophrenia; CESC cis rs2439831 0.867 rs689616 chr15:43761901 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.17 0.6 2.26e-27 Lung cancer in ever smokers; CESC cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg05283184 chr6:79620031 NA -0.44 -6.88 -0.39 4.39e-11 Intelligence (multi-trait analysis); CESC trans rs7839040 0.662 rs7812509 chr8:82931291 C/G cg14472086 chr9:107730925 NA -0.48 -6.45 -0.37 5.4e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs2120019 1.000 rs7162900 chr15:75368017 T/C cg17294928 chr15:75287854 SCAMP5 -0.59 -6.7 -0.38 1.28e-10 Blood trace element (Zn levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08118649 chr12:99038419 APAF1;IKBIP 0.6 6.57 0.37 2.64e-10 Gut microbiome composition (summer); CESC cis rs6901004 0.935 rs9487602 chr6:111560946 C/T cg15721981 chr6:111408429 SLC16A10 0.39 5.88 0.34 1.25e-8 Blood metabolite levels; CESC cis rs7267979 1.000 rs6083813 chr20:25337671 A/G cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.85e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9549260 0.569 rs73174811 chr13:41315998 T/G cg21288729 chr13:41239152 FOXO1 0.64 5.8 0.34 1.91e-8 Red blood cell count; CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg09177884 chr7:1199841 ZFAND2A -0.66 -8.88 -0.48 1e-16 Longevity;Endometriosis; CESC cis rs7520050 0.778 rs2088102 chr1:46032974 T/C cg06784218 chr1:46089804 CCDC17 -0.34 -5.95 -0.34 8.46e-9 Red blood cell count;Reticulocyte count; CESC trans rs6084875 0.641 rs2093388 chr20:4724219 A/G cg10192164 chr16:30419175 ZNF771 -0.51 -6.18 -0.35 2.46e-9 Systemic lupus erythematosus; CESC cis rs12780046 0.572 rs2796764 chr10:100960710 T/C cg27143070 chr10:101087766 CNNM1 0.39 5.66 0.33 3.94e-8 Non-glioblastoma glioma; CESC cis rs35123781 1.000 rs600848 chr5:139057270 T/C cg10513866 chr5:139070639 NA 0.37 5.37 0.31 1.75e-7 Schizophrenia; CESC cis rs62432291 0.681 rs436277 chr6:159634142 G/A cg14500486 chr6:159655392 FNDC1 0.57 5.99 0.35 6.78e-9 Joint mobility (Beighton score); CESC cis rs4481887 0.927 rs10888340 chr1:248440381 C/T cg00666640 chr1:248458726 OR2T12 0.41 6.81 0.39 6.41e-11 Common traits (Other); CESC cis rs539096 0.540 rs3011219 chr1:44306120 A/G cg13606994 chr1:44402422 ARTN -0.34 -5.1 -0.3 6.42e-7 Intelligence (multi-trait analysis); CESC cis rs7607369 0.618 rs62193298 chr2:219655211 T/G cg02176678 chr2:219576539 TTLL4 -0.47 -8.21 -0.45 9.61e-15 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg23161317 chr6:28129485 ZNF389 0.48 5.97 0.34 7.7e-9 Depression; CESC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg18876405 chr7:65276391 NA -0.55 -6.01 -0.35 6.19e-9 Aortic root size; CESC cis rs6460942 0.597 rs4721105 chr7:12534881 C/T cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg04287289 chr16:89883240 FANCA -0.48 -5.89 -0.34 1.16e-8 Vitiligo; CESC cis rs765787 0.530 rs7167731 chr15:45510900 T/C cg24006582 chr15:45444508 DUOX1 0.52 6.34 0.36 9.88e-10 Uric acid levels; CESC cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg14393609 chr7:65229607 NA 0.42 5.47 0.32 1.05e-7 Aortic root size; CESC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg03609598 chr5:56110824 MAP3K1 -0.51 -5.32 -0.31 2.22e-7 Initial pursuit acceleration; CESC cis rs61931739 0.534 rs11053131 chr12:34282109 A/G cg06521331 chr12:34319734 NA -0.43 -6.01 -0.35 6.16e-9 Morning vs. evening chronotype; CESC cis rs6687430 0.532 rs17035305 chr1:10616505 C/A cg20482658 chr1:10539492 PEX14 0.39 8.06 0.44 2.69e-14 Hand grip strength; CESC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.87 12.45 0.61 2.52e-28 Prudent dietary pattern; CESC cis rs3749237 0.595 rs3870338 chr3:49557051 A/G cg02487422 chr3:49467188 NICN1 0.56 8.22 0.45 9.05e-15 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19224713 chr8:119634283 SAMD12 0.55 6.33 0.36 1.03e-9 Gut microbiome composition (summer); CESC cis rs67478160 0.634 rs2368559 chr14:104230535 C/T cg08213375 chr14:104286397 PPP1R13B 0.46 9.0 0.48 4.6e-17 Schizophrenia; CESC trans rs6951245 0.580 rs77101766 chr7:1122438 A/G cg13565492 chr6:43139072 SRF -0.73 -8.6 -0.47 7.12e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg06550200 chr5:1325588 CLPTM1L -0.68 -10.37 -0.54 2.33e-21 Lung cancer; CESC trans rs1443125 0.901 rs16903272 chr8:129631541 A/G cg18172051 chr1:29189940 OPRD1 0.56 6.04 0.35 5.06e-9 Perceived unattractiveness to mosquitoes; CESC cis rs17253792 0.822 rs80085988 chr14:56096173 A/G cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs9811920 0.638 rs793474 chr3:99544380 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.63 10.34 0.54 2.93e-21 Axial length; CESC cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg02487422 chr3:49467188 NICN1 0.39 5.05 0.3 8.06e-7 Parkinson's disease; CESC cis rs72781680 1.000 rs72781663 chr2:24221694 C/G cg20701182 chr2:24300061 SF3B14 0.65 5.68 0.33 3.52e-8 Lymphocyte counts; CESC cis rs9303401 0.614 rs62084384 chr17:57126842 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.98 12.19 0.6 1.95e-27 Cognitive test performance; CESC cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg13298116 chr11:62369859 EML3;MTA2 0.65 9.46 0.5 1.75e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs1814175 0.740 rs10839439 chr11:49918240 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -20.27 -0.78 8.31e-56 Height; CESC cis rs684232 0.602 rs2160955 chr17:560604 T/C cg12384639 chr17:618140 VPS53 0.42 5.38 0.31 1.61e-7 Prostate cancer; CESC cis rs10089 0.953 rs17164427 chr5:127361736 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.74 -9.89 -0.52 7.84e-20 Ileal carcinoids; CESC cis rs7089973 0.604 rs7903663 chr10:116609904 G/A cg25233709 chr10:116636983 FAM160B1 0.38 6.14 0.35 3.07e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs854765 0.583 rs9904163 chr17:17830553 C/T cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.93e-9 Total body bone mineral density; CESC cis rs7178572 1.000 rs34591043 chr15:77713586 A/G cg22256960 chr15:77711686 NA -0.58 -7.92 -0.44 6.36e-14 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26735824 chr11:121163657 SC5DL 0.59 6.9 0.39 3.84e-11 Gut microbiome composition (summer); CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg09033563 chr22:24373618 LOC391322 -0.4 -5.27 -0.31 2.79e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4423214 1.000 rs2852853 chr11:71150217 C/T cg05163923 chr11:71159392 DHCR7 0.71 9.5 0.5 1.31e-18 Vitamin D levels; CESC cis rs2050392 0.894 rs303430 chr10:30706235 C/A cg25182066 chr10:30743637 MAP3K8 -0.4 -5.36 -0.31 1.77e-7 Inflammatory bowel disease; CESC cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.85 7.34 0.41 2.57e-12 Initial pursuit acceleration; CESC cis rs11792861 0.855 rs72607165 chr9:111814498 C/T cg05043794 chr9:111880884 C9orf5 -0.39 -6.4 -0.37 6.82e-10 Menarche (age at onset); CESC cis rs1707322 0.963 rs4630155 chr1:46257110 G/C cg05343316 chr1:45956843 TESK2 0.51 6.25 0.36 1.59e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg00339695 chr16:24857497 SLC5A11 -0.53 -6.58 -0.37 2.56e-10 Intelligence (multi-trait analysis); CESC cis rs796364 0.806 rs76568708 chr2:200929531 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.86 -7.87 -0.44 9.02e-14 Schizophrenia; CESC cis rs10931896 0.531 rs295118 chr2:201144004 C/T cg23649088 chr2:200775458 C2orf69 0.53 7.38 0.41 2.06e-12 Systolic blood pressure; CESC cis rs2901656 1.000 rs2901656 chr1:172434812 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.41 6.41 0.37 6.45e-10 Red cell distribution width;Platelet distribution width; CESC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg24675658 chr1:53192096 ZYG11B -0.56 -6.9 -0.39 3.75e-11 Monocyte count; CESC cis rs2832191 0.755 rs55671430 chr21:30492421 G/C cg24692254 chr21:30365293 RNF160 -0.79 -12.11 -0.6 3.54e-27 Dental caries; CESC cis rs4566357 1.000 rs4296417 chr2:227921941 G/A cg11843606 chr2:227700838 RHBDD1 -0.41 -5.27 -0.31 2.77e-7 Coronary artery disease; CESC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg18099408 chr3:52552593 STAB1 -0.32 -5.36 -0.31 1.78e-7 Bipolar disorder; CESC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg18876405 chr7:65276391 NA -0.51 -7.01 -0.4 1.94e-11 Aortic root size; CESC cis rs72945132 0.882 rs4567496 chr11:70193208 A/T cg00319359 chr11:70116639 PPFIA1 0.82 7.36 0.41 2.35e-12 Coronary artery disease; CESC cis rs6502050 0.835 rs9891962 chr17:80153594 T/C cg23985595 chr17:80112537 CCDC57 -0.39 -6.19 -0.36 2.23e-9 Life satisfaction; CESC cis rs1728785 0.591 rs10775305 chr16:68656460 A/G cg02972257 chr16:68554789 NA -0.63 -7.02 -0.4 1.86e-11 Ulcerative colitis; CESC cis rs4450798 0.649 rs9878907 chr3:13791196 T/C cg23332027 chr3:13681764 NA 0.38 5.13 0.3 5.63e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7944584 1.000 rs7944584 chr11:47336320 A/T cg20307385 chr11:47447363 PSMC3 0.69 8.04 0.44 3.02e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs3733585 0.638 rs7377625 chr4:9953099 T/C cg00071950 chr4:10020882 SLC2A9 -0.69 -11.27 -0.57 2.44e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs5758511 0.680 rs5758688 chr22:42662501 T/C cg00645731 chr22:42541494 CYP2D7P1 0.58 8.76 0.47 2.43e-16 Birth weight; CESC cis rs7589342 0.801 rs13031068 chr2:106455021 A/G cg16077055 chr2:106428750 NCK2 0.49 6.99 0.39 2.27e-11 Addiction; CESC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg22143856 chr6:28129313 ZNF389 0.42 5.34 0.31 1.98e-7 Parkinson's disease; CESC cis rs1451375 0.652 rs7803788 chr7:50625898 A/G cg14593290 chr7:50529359 DDC -0.44 -5.28 -0.31 2.65e-7 Malaria; CESC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4953076 0.573 rs7602070 chr2:44388614 G/A cg04920474 chr2:44395004 PPM1B 0.51 6.36 0.36 9.01e-10 Height; CESC cis rs2243480 0.808 rs12698508 chr7:65411958 A/T cg25894440 chr7:65020034 NA -0.63 -5.26 -0.31 2.91e-7 Diabetic kidney disease; CESC cis rs709400 0.628 rs11622320 chr14:103912194 A/T cg12935359 chr14:103987150 CKB -0.57 -8.42 -0.46 2.43e-15 Body mass index; CESC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg08859206 chr1:53392774 SCP2 -0.6 -8.02 -0.44 3.43e-14 Monocyte count; CESC cis rs5743618 0.537 rs11466661 chr4:38774482 G/T cg02016764 chr4:38805732 TLR1 -0.32 -5.04 -0.3 8.7e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs79839061 0.610 rs73207794 chr4:872020 T/C cg07828340 chr4:882639 GAK 1.07 8.28 0.45 6.23e-15 Intelligence (multi-trait analysis); CESC cis rs11785693 0.819 rs6994891 chr8:4989856 T/A cg26367366 chr8:4980734 NA 0.94 8.56 0.47 9.04e-16 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs13256369 0.853 rs13256216 chr8:8577883 C/T cg17143192 chr8:8559678 CLDN23 0.7 7.73 0.43 2.25e-13 Obesity-related traits; CESC cis rs1943345 0.642 rs11233500 chr11:82881407 C/T cg07047830 chr11:82868014 PCF11 -0.61 -8.39 -0.46 2.87e-15 Obesity-related traits; CESC cis rs11958404 0.932 rs112993559 chr5:157414712 A/C cg05962755 chr5:157440814 NA 0.62 6.72 0.38 1.08e-10 IgG glycosylation; CESC cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg02079420 chr8:82753780 SNX16 0.52 7.77 0.43 1.71e-13 Diastolic blood pressure; CESC cis rs2050392 0.517 rs687036 chr10:30761249 G/A cg25182066 chr10:30743637 MAP3K8 -0.49 -6.93 -0.39 3.24e-11 Inflammatory bowel disease; CESC cis rs1577917 1.000 rs13196930 chr6:86652245 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.33 -0.36 1.04e-9 Response to antipsychotic treatment; CESC cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg05283184 chr6:79620031 NA -0.44 -6.79 -0.39 7.19e-11 Intelligence (multi-trait analysis); CESC cis rs12887734 0.546 rs12885509 chr14:104273325 T/C cg08213375 chr14:104286397 PPP1R13B 0.41 6.84 0.39 5.38e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs17023223 0.537 rs12083510 chr1:119746620 T/G cg05756136 chr1:119680316 WARS2 -0.48 -5.7 -0.33 3.25e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04558166 chr1:210001279 C1orf107 -0.45 -7.38 -0.41 2.06e-12 Gambling; CESC cis rs6831352 0.918 rs17218288 chr4:100058030 A/T cg13256891 chr4:100009986 ADH5 -0.77 -8.46 -0.46 1.82e-15 Alcohol dependence; CESC cis rs1005277 0.505 rs200910 chr10:38108176 C/T cg00409905 chr10:38381863 ZNF37A -0.55 -7.63 -0.42 4.18e-13 Extrinsic epigenetic age acceleration; CESC trans rs11098499 0.913 rs68128210 chr4:120137819 T/G cg25214090 chr10:38739885 LOC399744 0.63 8.33 0.46 4.44e-15 Corneal astigmatism; CESC cis rs7932354 0.528 rs4752952 chr11:47082858 T/C cg25783544 chr11:47291846 MADD -0.41 -5.47 -0.32 1.05e-7 Bone mineral density (hip);Bone mineral density; CESC cis rs7071206 0.947 rs10824560 chr10:79416901 C/T cg00983440 chr10:79422392 NA -0.67 -8.17 -0.45 1.3e-14 Bone mineral density; CESC cis rs3733585 0.648 rs7376155 chr4:9952588 C/T cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1707322 0.752 rs6703748 chr1:46095976 G/A cg03146154 chr1:46216737 IPP 0.81 11.43 0.57 7.16e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7412746 0.658 rs10888397 chr1:150886752 A/G cg17724175 chr1:150552817 MCL1 -0.39 -6.12 -0.35 3.28e-9 Melanoma; CESC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg10295955 chr4:187884368 NA -1.08 -23.01 -0.82 4.07e-65 Lobe attachment (rater-scored or self-reported); CESC cis rs6032067 1.000 rs35284867 chr20:43845836 A/T cg11264863 chr20:43835661 SEMG1 0.48 5.19 0.3 4.24e-7 Blood protein levels; CESC cis rs2742417 0.603 rs2742371 chr3:45782763 G/A cg04837898 chr3:45731254 SACM1L -0.46 -6.04 -0.35 5.31e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg03433033 chr1:76189801 ACADM -0.62 -7.15 -0.4 8.57e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.86 -8.67 -0.47 4.32e-16 Schizophrenia; CESC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 11.77 0.59 5.44e-26 Platelet count; CESC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg24675658 chr1:53192096 ZYG11B -0.56 -6.9 -0.39 3.75e-11 Monocyte count; CESC cis rs1784581 0.802 rs7768986 chr6:162427890 G/C cg17173639 chr6:162384350 PARK2 0.61 9.55 0.51 9.38e-19 Itch intensity from mosquito bite; CESC cis rs67257959 0.708 rs1979261 chr19:17193518 C/T cg16202187 chr19:17186497 HAUS8;MYO9B -0.46 -5.58 -0.32 6.04e-8 Selective IgA deficiency; CESC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 5.26 0.31 3.03e-7 Electroencephalogram traits; CESC cis rs4319547 1.000 rs7295397 chr12:123116209 C/T cg23029597 chr12:123009494 RSRC2 -0.49 -5.37 -0.31 1.74e-7 Body mass index; CESC cis rs4843747 0.605 rs28399183 chr16:88107277 G/A cg03395651 chr16:88107091 BANP 0.45 5.26 0.31 2.98e-7 Menopause (age at onset); CESC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg17724175 chr1:150552817 MCL1 0.44 7.23 0.41 5.25e-12 Tonsillectomy; CESC cis rs4727027 0.835 rs11767810 chr7:148774433 T/A cg23158103 chr7:148848205 ZNF398 -0.41 -6.53 -0.37 3.38e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.97 10.28 0.53 4.51e-21 Platelet count; CESC cis rs3126085 0.935 rs11204980 chr1:152296191 G/C cg03465714 chr1:152285911 FLG 0.5 5.71 0.33 2.96e-8 Atopic dermatitis; CESC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg05332525 chr7:65337924 VKORC1L1 0.51 6.35 0.36 9.52e-10 Calcium levels; CESC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg11890956 chr21:40555474 PSMG1 1.16 20.96 0.79 3.6e-58 Cognitive function; CESC cis rs4243830 1.000 rs11811007 chr1:6584657 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 0.69 5.88 0.34 1.24e-8 Body mass index; CESC cis rs2806561 0.704 rs664301 chr1:23522522 C/T cg12483005 chr1:23474871 LUZP1 0.43 6.55 0.37 2.93e-10 Height; CESC trans rs11098499 0.615 rs28551750 chr4:120264901 C/T cg25214090 chr10:38739885 LOC399744 0.6 8.26 0.45 6.87e-15 Corneal astigmatism; CESC cis rs9479482 0.935 rs5017315 chr6:150333574 C/T cg03788504 chr6:150331562 NA -0.35 -7.05 -0.4 1.54e-11 Alopecia areata; CESC cis rs34526934 0.608 rs7591820 chr2:177028144 G/T cg14324370 chr2:177042789 NA -0.5 -6.1 -0.35 3.65e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs68170813 0.559 rs3801959 chr7:106955666 A/G cg02696742 chr7:106810147 HBP1 -0.54 -5.17 -0.3 4.72e-7 Coronary artery disease; CESC cis rs8103278 0.507 rs62111759 chr19:46296230 A/T cg02376097 chr19:46275166 DMPK 0.38 5.64 0.33 4.26e-8 Coronary artery disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg22328890 chr16:68298258 SLC7A6 0.5 6.83 0.39 5.71e-11 Systemic lupus erythematosus; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg24555065 chr12:6977392 TPI1 -0.47 -6.22 -0.36 1.92e-9 Height; CESC cis rs2274273 0.638 rs58269011 chr14:55684388 A/G cg04306507 chr14:55594613 LGALS3 0.31 5.26 0.31 3.03e-7 Protein biomarker; CESC cis rs208520 0.837 rs208486 chr6:66926255 A/T cg07460842 chr6:66804631 NA -0.88 -10.55 -0.54 6.07e-22 Exhaled nitric oxide output; CESC trans rs637571 0.676 rs1151523 chr11:65665200 C/T cg17712092 chr4:129076599 LARP1B -0.75 -10.22 -0.53 6.83e-21 Eosinophil percentage of white cells; CESC cis rs6448317 0.539 rs13113895 chr4:24932077 T/C cg21108841 chr4:24914750 CCDC149 -0.57 -8.04 -0.44 3e-14 Heschl's gyrus morphology; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20708961 chr19:22235256 ZNF257 0.42 6.31 0.36 1.2e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9479482 1.000 rs9479481 chr6:150357944 A/G cg03788504 chr6:150331562 NA -0.38 -7.22 -0.41 5.37e-12 Alopecia areata; CESC cis rs10078 0.510 rs2278248 chr5:469570 G/T cg08916839 chr5:415575 AHRR 0.51 6.01 0.35 6.26e-9 Fat distribution (HIV); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09228562 chr1:182808478 DHX9 0.54 6.17 0.35 2.56e-9 Gut microbiome composition (summer); CESC cis rs9815354 0.812 rs4434125 chr3:42004681 A/G cg03022575 chr3:42003672 ULK4 0.65 5.73 0.33 2.75e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs950169 0.650 rs12902052 chr15:85125838 A/T cg17507749 chr15:85114479 UBE2QP1 0.54 6.09 0.35 3.99e-9 Schizophrenia; CESC cis rs116095464 0.558 rs1971229 chr5:268187 A/G cg20965017 chr5:231967 SDHA -0.48 -5.43 -0.32 1.25e-7 Breast cancer; CESC cis rs7762018 0.655 rs2184194 chr6:170148394 C/T cg13891659 chr6:170190454 C6orf122;C6orf208 0.67 6.53 0.37 3.28e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs75477785 0.590 rs10863789 chr1:209987919 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.03 -0.35 5.5e-9 Parkinson's disease; CESC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg08736216 chr1:53307985 ZYG11A -0.4 -6.55 -0.37 2.93e-10 Monocyte count; CESC cis rs2235642 0.891 rs2281231 chr16:1601879 A/G cg03771183 chr16:1608904 IFT140 0.4 5.84 0.34 1.52e-8 Coronary artery disease; CESC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg12193833 chr17:30244370 NA 0.54 5.46 0.32 1.09e-7 Hip circumference adjusted for BMI; CESC cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg07636037 chr3:49044803 WDR6 1.03 19.1 0.76 1e-51 Parkinson's disease; CESC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg10691866 chr7:65817282 TPST1 0.32 5.42 0.32 1.35e-7 Aortic root size; CESC trans rs2797160 0.967 rs4897151 chr6:125993202 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.01 -0.35 6.16e-9 Endometrial cancer; CESC cis rs9916302 0.861 rs11658219 chr17:37709782 G/A cg07936489 chr17:37558343 FBXL20 -0.81 -11.66 -0.58 1.27e-25 Glomerular filtration rate (creatinine); CESC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.5 -6.23 -0.36 1.78e-9 Tonsillectomy; CESC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg27121462 chr16:89883253 FANCA -0.81 -12.17 -0.6 2.33e-27 Vitiligo; CESC cis rs6500602 0.929 rs6500603 chr16:4497537 G/C cg08645402 chr16:4508243 NA 0.46 6.96 0.39 2.72e-11 Schizophrenia; CESC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg26335602 chr6:28129616 ZNF389 0.52 6.85 0.39 5.22e-11 Depression; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15543284 chr2:54785307 SPTBN1 -0.45 -6.12 -0.35 3.31e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1008375 1.000 rs555 chr4:17625658 A/G cg02297831 chr4:17616191 MED28 0.54 6.9 0.39 3.75e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg14413466 chr17:79170920 AZI1 -0.44 -6.72 -0.38 1.12e-10 Frontotemporal dementia; CESC cis rs4727963 0.811 rs7458859 chr7:122711358 C/T cg03640110 chr7:122635026 TAS2R16 0.37 5.87 0.34 1.33e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs61861422 0.516 rs12412216 chr10:134393338 C/T cg26818010 chr10:134567672 INPP5A -0.59 -5.45 -0.32 1.15e-7 Primary sclerosing cholangitis; CESC cis rs8050907 0.744 rs8063084 chr16:4536555 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.71 5.05 0.3 8.06e-7 Obesity-related traits; CESC cis rs1018836 0.923 rs4734266 chr8:91628147 C/T cg16814680 chr8:91681699 NA -0.72 -9.98 -0.52 3.92e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1986734 0.619 rs13106413 chr4:77418698 G/T cg20311846 chr4:77356250 SHROOM3 -0.27 -5.47 -0.32 1.06e-7 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC cis rs10751667 0.580 rs7395515 chr11:1005160 C/T cg06064525 chr11:970664 AP2A2 -0.32 -5.5 -0.32 9.11e-8 Alzheimer's disease (late onset); CESC cis rs7659604 0.540 rs4833775 chr4:122716826 T/C cg19671926 chr4:122722719 EXOSC9 0.67 8.93 0.48 7.16e-17 Type 2 diabetes; CESC cis rs965469 1.000 rs6051713 chr20:3265779 C/T cg25506879 chr20:3388711 C20orf194 0.51 5.47 0.32 1.04e-7 IFN-related cytopenia; CESC cis rs7772486 0.846 rs6908063 chr6:146403618 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.59 0.38 2.4e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.49 0.32 9.27e-8 Bipolar disorder; CESC cis rs2797160 1.000 rs61299898 chr6:126007651 G/C cg05901451 chr6:126070800 HEY2 0.45 6.53 0.37 3.43e-10 Endometrial cancer; CESC cis rs35110281 0.837 rs2838343 chr21:45078035 C/T cg04455712 chr21:45112962 RRP1B 0.41 6.09 0.35 3.89e-9 Mean corpuscular volume; CESC cis rs4253772 0.591 rs9615934 chr22:46682310 C/G cg00784671 chr22:46762841 CELSR1 -0.56 -6.04 -0.35 5.06e-9 LDL cholesterol;Cholesterol, total; CESC cis rs1707322 1.000 rs6672115 chr1:46272879 T/C cg03146154 chr1:46216737 IPP 0.78 10.71 0.55 1.78e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs748404 0.697 rs475261 chr15:43546456 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.86 0.43 9.6e-14 Lung cancer; CESC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.62 0.38 1.93e-10 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05397629 chr11:3848986 RHOG 0.43 6.12 0.35 3.37e-9 Fibrinogen levels; CESC cis rs9549260 0.564 rs9577107 chr13:41271676 A/T cg21288729 chr13:41239152 FOXO1 0.59 7.68 0.43 2.99e-13 Red blood cell count; CESC trans rs9329221 0.683 rs525726 chr8:9887797 G/C cg15556689 chr8:8085844 FLJ10661 -0.54 -7.05 -0.4 1.54e-11 Neuroticism; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00788375 chr19:7745377 TRAPPC5 -0.39 -6.47 -0.37 4.72e-10 Gambling; CESC cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg02297831 chr4:17616191 MED28 -0.64 -7.7 -0.43 2.75e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05226292 chr8:71520850 TRAM1 0.58 7.03 0.4 1.77e-11 Gut microbiome composition (summer); CESC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC trans rs877282 0.898 rs71489279 chr10:760510 T/C cg22713356 chr15:30763199 NA 1.14 11.28 0.57 2.37e-24 Uric acid levels; CESC cis rs62432291 0.681 rs1699442 chr6:159655918 A/C cg14500486 chr6:159655392 FNDC1 0.6 5.98 0.34 7.22e-9 Joint mobility (Beighton score); CESC cis rs4803468 1.000 rs166925 chr19:41926098 T/C cg14132834 chr19:41945861 ATP5SL -0.67 -8.35 -0.46 3.83e-15 Height; CESC cis rs9287719 0.934 rs4371336 chr2:10755723 C/A cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg24531977 chr5:56204891 C5orf35 0.4 5.03 0.3 9.23e-7 Coronary artery disease; CESC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg24296786 chr1:45957014 TESK2 0.63 8.21 0.45 9.97e-15 High light scatter reticulocyte count; CESC cis rs3806843 0.750 rs2563285 chr5:140126137 T/C cg16179182 chr5:140090404 VTRNA1-1 0.39 5.1 0.3 6.59e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6582630 0.584 rs12832156 chr12:38419435 C/T cg26384229 chr12:38710491 ALG10B -0.42 -5.52 -0.32 8.2e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg08968635 chr6:28129556 ZNF389 0.42 5.72 0.33 2.86e-8 Depression; CESC cis rs1570884 0.516 rs2146144 chr13:50170245 C/T cg03651054 chr13:50194643 NA 0.31 5.08 0.3 7.07e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg20151795 chr6:28129481 ZNF389 0.46 5.81 0.34 1.76e-8 Depression; CESC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg26732615 chr19:19648335 CILP2;YJEFN3 -0.41 -5.24 -0.31 3.25e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08195029 chr19:9695212 ZNF121 0.55 6.0 0.35 6.3e-9 Gut microbiome composition (summer); CESC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg01341218 chr17:43662625 NA 0.92 10.64 0.55 3.07e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.72 9.89 0.52 7.62e-20 Total body bone mineral density; CESC cis rs3540 0.574 rs2657947 chr15:90968977 C/T cg10434728 chr15:90938212 IQGAP1 -0.4 -7.05 -0.4 1.52e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs17608059 0.710 rs8080167 chr17:13949828 G/A cg11395062 chr17:14139857 CDRT15 0.48 6.27 0.36 1.45e-9 Temperament; CESC cis rs116095464 0.850 rs6896163 chr5:303686 A/G cg22857025 chr5:266934 NA -1.2 -10.61 -0.55 3.75e-22 Breast cancer; CESC trans rs9929218 0.861 rs4783667 chr16:68752878 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -10.48 -0.54 1.03e-21 Colorectal cancer; CESC cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg05340658 chr4:99064831 C4orf37 0.78 11.87 0.59 2.5e-26 Colonoscopy-negative controls vs population controls; CESC cis rs9287719 0.601 rs12692412 chr2:10720054 A/G cg00105475 chr2:10696890 NA -0.39 -5.42 -0.32 1.36e-7 Prostate cancer; CESC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg24578937 chr1:2090814 PRKCZ 0.38 6.62 0.38 2.03e-10 Height; CESC cis rs6460942 0.915 rs62447642 chr7:12489147 T/C cg10578991 chr7:12443926 VWDE -0.49 -5.22 -0.31 3.59e-7 Coronary artery disease; CESC cis rs2294693 0.945 rs9369253 chr6:40986538 A/G cg14418226 chr6:40996092 UNC5CL 0.54 6.44 0.37 5.51e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs6728861 1 rs6728861 chr2:203873743 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.83 7.17 0.4 7.34e-12 Coronary artery disease; CESC trans rs7944735 0.507 rs17198607 chr11:48028343 A/C cg15704280 chr7:45808275 SEPT13 -0.71 -6.41 -0.37 6.71e-10 Intraocular pressure; CESC trans rs11039798 0.588 rs11039818 chr11:48562120 C/T cg03929089 chr4:120376271 NA 0.6 6.12 0.35 3.35e-9 Axial length; CESC cis rs4771122 0.500 rs1049302 chr13:27998769 T/C cg22138327 chr13:27999177 GTF3A -0.88 -11.9 -0.59 1.96e-26 Body mass index; CESC cis rs2204008 0.623 rs1607878 chr12:38376000 A/G cg26384229 chr12:38710491 ALG10B 0.67 9.88 0.52 8.42e-20 Bladder cancer; CESC cis rs6088580 0.608 rs8114616 chr20:32969092 G/T cg06115741 chr20:33292138 TP53INP2 -0.46 -5.9 -0.34 1.09e-8 Glomerular filtration rate (creatinine); CESC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg16145915 chr7:1198662 ZFAND2A -0.48 -7.15 -0.4 8.52e-12 Longevity;Endometriosis; CESC cis rs7927771 1.000 rs7927771 chr11:47781306 A/G cg18512352 chr11:47633146 NA -0.61 -9.64 -0.51 4.87e-19 Subjective well-being; CESC cis rs193541 0.632 rs30036 chr5:122278260 A/G cg19412675 chr5:122181750 SNX24 0.42 5.03 0.3 9.19e-7 Glucose homeostasis traits; CESC cis rs616402 0.527 rs2274985 chr1:10573867 G/A cg07384165 chr1:10488281 NA -0.58 -8.57 -0.47 8.45e-16 Breast size; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19862918 chr17:40761350 FAM134C;TUBG1 -0.49 -6.11 -0.35 3.59e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg07395648 chr5:131743802 NA -0.46 -6.12 -0.35 3.41e-9 Breast cancer; CESC cis rs6963495 0.818 rs73190181 chr7:105162907 A/C cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs9309711 0.770 rs13409323 chr2:3488184 C/T cg10845886 chr2:3471009 TTC15 -0.84 -11.56 -0.58 2.71e-25 Neurofibrillary tangles; CESC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.94 -0.56 3.04e-23 Alzheimer's disease; CESC cis rs2637266 0.703 rs846593 chr10:78504258 T/C cg18941641 chr10:78392320 NA 0.38 7.53 0.42 7.77e-13 Pulmonary function; CESC cis rs2979489 0.533 rs62505280 chr8:30448124 C/T cg26383811 chr8:30366931 RBPMS -0.66 -7.8 -0.43 1.4e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs4319547 0.774 rs7307233 chr12:123124301 C/G cg23029597 chr12:123009494 RSRC2 -0.45 -5.2 -0.3 4.02e-7 Body mass index; CESC cis rs1355223 0.902 rs448016 chr11:34706593 A/C cg11058730 chr11:34937778 PDHX;APIP 0.5 6.79 0.38 7.5e-11 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs763121 0.853 rs6001214 chr22:39149155 C/T cg06022373 chr22:39101656 GTPBP1 0.92 15.76 0.7 6.4e-40 Menopause (age at onset); CESC cis rs4910157 1 rs4910157 chr11:8941215 A/G cg12365402 chr11:9010492 NRIP3 0.37 5.76 0.33 2.32e-8 Tonsillectomy; CESC cis rs2204008 0.837 rs11181857 chr12:38413255 C/G cg13010199 chr12:38710504 ALG10B 0.42 5.52 0.32 8.24e-8 Bladder cancer; CESC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg06456125 chr7:65229604 NA 0.42 5.28 0.31 2.74e-7 Aortic root size; CESC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg27170947 chr2:26402098 FAM59B -0.71 -8.27 -0.45 6.5e-15 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.19 0.3 4.29e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11098499 0.691 rs9996494 chr4:120238880 C/A cg09307838 chr4:120376055 NA 0.78 10.46 0.54 1.15e-21 Corneal astigmatism; CESC cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg01475377 chr6:109611718 NA -0.51 -8.56 -0.47 9.01e-16 Reticulocyte fraction of red cells; CESC cis rs9611565 0.592 rs5758405 chr22:42076381 C/A cg03806693 chr22:41940476 POLR3H 1.01 11.96 0.59 1.19e-26 Vitiligo; CESC cis rs10823500 0.674 rs7089860 chr10:71992848 C/G cg02100629 chr10:71892760 AIFM2 -0.35 -5.52 -0.32 7.91e-8 Blood protein levels; CESC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg09658497 chr7:2847517 GNA12 0.37 5.27 0.31 2.79e-7 Height; CESC cis rs7927592 0.763 rs10896340 chr11:68312645 A/G cg16797656 chr11:68205561 LRP5 -0.48 -7.41 -0.41 1.7e-12 Total body bone mineral density; CESC cis rs2839186 0.933 rs56955294 chr21:47708953 A/G cg10351095 chr21:47802916 PCNT -0.5 -6.69 -0.38 1.35e-10 Testicular germ cell tumor; CESC cis rs8027181 0.839 rs7176223 chr15:73077742 T/G cg25632853 chr15:73088954 NA 0.31 5.48 0.32 1e-7 Triglyceride levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09242721 chr3:3168535 TRNT1 -0.45 -6.1 -0.35 3.73e-9 Fibrinogen levels; CESC cis rs7605827 0.930 rs7596951 chr2:15513473 G/C cg19274914 chr2:15703543 NA 0.32 5.56 0.32 6.52e-8 Educational attainment (years of education); CESC cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.37 -5.65 -0.33 4.09e-8 Personality dimensions; CESC cis rs72848980 0.512 rs12359556 chr10:105390677 C/T cg00126946 chr10:105363258 SH3PXD2A 0.59 8.47 0.46 1.66e-15 White matter hyperintensity burden; CESC cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg01181863 chr3:195395398 SDHAP2 -0.47 -5.45 -0.32 1.15e-7 Pancreatic cancer; CESC cis rs12545109 0.800 rs2118260 chr8:57393481 T/C cg09654669 chr8:57350985 NA -0.54 -6.56 -0.37 2.86e-10 Obesity-related traits; CESC cis rs7264396 0.635 rs6121073 chr20:34457513 G/A cg17201900 chr20:34330562 RBM39 0.52 5.3 0.31 2.44e-7 Total cholesterol levels; CESC cis rs7561273 0.609 rs10197527 chr2:24352398 A/C cg20701182 chr2:24300061 SF3B14 0.46 6.01 0.35 6.27e-9 Quantitative traits; CESC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg07870213 chr5:140052090 DND1 -0.61 -6.87 -0.39 4.47e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg11890956 chr21:40555474 PSMG1 -0.98 -15.85 -0.7 2.96e-40 Cognitive function; CESC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg06074448 chr4:187884817 NA 0.38 5.18 0.3 4.33e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs1144333 1.000 rs5745343 chr1:76273805 A/G cg03433033 chr1:76189801 ACADM -0.51 -5.41 -0.32 1.41e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs950776 0.518 rs4887062 chr15:78837801 G/A cg06917634 chr15:78832804 PSMA4 -0.76 -11.22 -0.57 3.72e-24 Sudden cardiac arrest; CESC cis rs9311474 0.713 rs352165 chr3:52242902 A/G cg07507251 chr3:52567010 NT5DC2 0.35 6.25 0.36 1.67e-9 Electroencephalogram traits; CESC cis rs72634258 0.519 rs4908487 chr1:7937437 C/T cg00042356 chr1:8021962 PARK7 0.6 5.73 0.33 2.72e-8 Inflammatory bowel disease; CESC trans rs11098499 0.866 rs12374352 chr4:120281977 C/T cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs67460515 0.892 rs7648279 chr3:160979646 G/A cg03342759 chr3:160939853 NMD3 -0.54 -7.71 -0.43 2.55e-13 Parkinson's disease; CESC cis rs9837602 0.938 rs17393059 chr3:99761908 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 7.14 0.4 8.96e-12 Breast cancer; CESC cis rs6484504 0.576 rs11031324 chr11:31250299 T/C cg14844989 chr11:31128820 NA -0.42 -5.94 -0.34 9.07e-9 Red blood cell count; CESC cis rs6582630 0.555 rs10880421 chr12:38423015 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.51 0.54 7.9e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs7130144 0.541 rs7110730 chr11:130457867 C/T cg26307797 chr11:130446613 NA -0.8 -6.52 -0.37 3.61e-10 Urate levels in lean individuals; CESC cis rs847577 0.609 rs6977321 chr7:97774859 A/G cg21770322 chr7:97807741 LMTK2 0.84 14.14 0.66 3.26e-34 Breast cancer; CESC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.66 0.38 1.54e-10 Bipolar disorder; CESC cis rs365132 0.875 rs2962842 chr5:176338955 A/G cg16309518 chr5:176445507 NA -0.39 -5.66 -0.33 3.95e-8 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg27211696 chr2:191398769 TMEM194B -0.5 -7.58 -0.42 5.86e-13 Pulse pressure; CESC cis rs3733585 0.673 rs4560411 chr4:9953361 A/G cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg24846343 chr22:24311635 DDTL 0.64 11.14 0.56 6.74e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4727963 0.811 rs1404837 chr7:122696659 A/T cg03640110 chr7:122635026 TAS2R16 0.37 5.81 0.34 1.76e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs1707322 0.721 rs12043945 chr1:46106922 T/A cg03146154 chr1:46216737 IPP 0.82 11.48 0.58 4.81e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg09177884 chr7:1199841 ZFAND2A -0.41 -5.13 -0.3 5.62e-7 Longevity;Endometriosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15564865 chr6:4021423 PRPF4B 0.47 6.15 0.35 2.79e-9 Gut microbiota (bacterial taxa); CESC cis rs77741769 0.571 rs1542859 chr12:121336766 A/G cg02419362 chr12:121203948 SPPL3 0.35 5.6 0.33 5.35e-8 Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14872693 chr11:65190203 NEAT1 -0.43 -6.02 -0.35 5.69e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg24549020 chr5:56110836 MAP3K1 0.66 7.45 0.42 1.29e-12 Initial pursuit acceleration; CESC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg25204440 chr1:209979598 IRF6 0.66 6.52 0.37 3.63e-10 Cleft lip with or without cleft palate; CESC cis rs9325144 0.555 rs61929925 chr12:38698828 C/A cg26384229 chr12:38710491 ALG10B -0.6 -8.5 -0.46 1.43e-15 Morning vs. evening chronotype; CESC cis rs9611565 0.546 rs34077262 chr22:42061639 A/G cg06481639 chr22:41940642 POLR3H 0.59 6.51 0.37 3.8e-10 Vitiligo; CESC cis rs7267979 0.844 rs6132824 chr20:25238173 T/C cg08601574 chr20:25228251 PYGB 0.42 5.81 0.34 1.77e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs6502050 0.835 rs4523985 chr17:80154466 C/A cg23985595 chr17:80112537 CCDC57 -0.39 -6.24 -0.36 1.77e-9 Life satisfaction; CESC cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg08564027 chr20:61660810 NA 0.92 15.61 0.69 2.2e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs9926296 0.681 rs12923946 chr16:89821080 C/T cg04287289 chr16:89883240 FANCA 0.62 8.04 0.44 3.07e-14 Vitiligo; CESC cis rs9583531 0.574 rs61971615 chr13:111353111 C/T cg15841412 chr13:111365552 ING1 -0.5 -6.38 -0.36 7.91e-10 Coronary artery disease; CESC cis rs2292864 0.764 rs35265764 chr17:45363546 G/T cg18085866 chr17:45331354 ITGB3 -0.63 -5.46 -0.32 1.09e-7 Left atrial antero-posterior diameter; CESC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg09177884 chr7:1199841 ZFAND2A -0.57 -7.48 -0.42 1.1e-12 Longevity;Endometriosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08262876 chr10:102757026 LZTS2 0.46 6.26 0.36 1.57e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 20.88 0.79 6.44e-58 Prudent dietary pattern; CESC cis rs61931739 0.500 rs11053140 chr12:34316122 T/C cg19457237 chr12:34500585 NA -0.37 -5.06 -0.3 7.75e-7 Morning vs. evening chronotype; CESC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.15 0.3 5e-7 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24848437 chr7:2645542 IQCE -0.51 -6.04 -0.35 5.06e-9 Gut microbiome composition (summer); CESC cis rs4835473 0.932 rs10030428 chr4:144683852 C/T cg25736465 chr4:144833511 NA 0.33 5.22 0.31 3.71e-7 Immature fraction of reticulocytes; CESC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg17971929 chr21:40555470 PSMG1 -0.86 -12.5 -0.61 1.69e-28 Cognitive function; CESC cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17472953 chr4:130014042 SCLT1;C4orf33 -0.57 -6.84 -0.39 5.5e-11 Gut microbiome composition (summer); CESC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg11941060 chr3:133502564 NA -0.49 -6.81 -0.39 6.41e-11 Iron status biomarkers; CESC cis rs2046867 0.818 rs6789061 chr3:72888690 C/T cg25664220 chr3:72788482 NA -0.46 -6.35 -0.36 9.09e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg13628971 chr7:2884303 GNA12 0.42 5.68 0.33 3.5e-8 Height; CESC cis rs12477438 0.765 rs72957180 chr2:99694452 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg22590775 chr19:49891494 CCDC155 0.58 6.97 0.39 2.46e-11 Multiple sclerosis; CESC cis rs11214589 0.905 rs1078 chr11:113241877 C/T cg14159747 chr11:113255604 NA 0.33 5.86 0.34 1.35e-8 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12227505 chr17:78194145 SLC26A11;SGSH 0.54 6.45 0.37 5.32e-10 Gut microbiome composition (summer); CESC cis rs6430585 0.583 rs6728946 chr2:136635343 C/G cg07169764 chr2:136633963 MCM6 1.31 20.8 0.79 1.22e-57 Corneal structure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16278828 chr15:75648574 MAN2C1 -0.55 -6.92 -0.39 3.45e-11 Gut microbiome composition (summer); CESC cis rs7959452 0.535 rs11615712 chr12:69619736 A/T cg14784868 chr12:69753453 YEATS4 -0.66 -9.17 -0.49 1.34e-17 Blood protein levels; CESC cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg03467027 chr4:99064603 C4orf37 0.45 5.67 0.33 3.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs703842 0.616 rs10877024 chr12:58226709 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.58 6.88 0.39 4.37e-11 Multiple sclerosis; CESC cis rs2806561 0.780 rs12117752 chr1:23360223 T/C cg12483005 chr1:23474871 LUZP1 -0.34 -5.37 -0.31 1.71e-7 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10971895 chr1:201438445 PHLDA3 -0.49 -6.04 -0.35 5.07e-9 Ulcerative colitis; CESC cis rs1707322 0.686 rs3014239 chr1:46089801 G/A cg05343316 chr1:45956843 TESK2 -0.52 -6.4 -0.37 7.03e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05062679 chr10:94000186 CPEB3 0.47 6.53 0.37 3.35e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg08645402 chr16:4508243 NA 0.42 5.92 0.34 1.01e-8 Schizophrenia; CESC cis rs28647808 1.000 rs4962145 chr9:136275188 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs7980687 0.506 rs1611973 chr12:123622731 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.07 -0.3 7.48e-7 Height;Educational attainment;Head circumference (infant); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg00529697 chr5:75013131 C5orf37 0.41 6.15 0.35 2.87e-9 Vertical cup-disc ratio; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20594226 chr2:87035716 CD8A -0.5 -6.39 -0.37 7.25e-10 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09538139 chr9:127532208 NR6A1 -0.56 -6.55 -0.37 3.04e-10 Gut microbiome composition (summer); CESC cis rs17376456 0.877 rs17315943 chr5:93442830 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.11 0.3 6.27e-7 Diabetic retinopathy; CESC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.51e-7 Life satisfaction; CESC cis rs11674184 0.743 rs12470971 chr2:11725241 A/G cg07314298 chr2:11723111 GREB1 0.65 10.02 0.52 3.02e-20 Endometriosis; CESC cis rs7116495 0.881 rs673478 chr11:71799104 G/A cg26138937 chr11:71823887 C11orf51 -0.87 -7.06 -0.4 1.42e-11 Severe influenza A (H1N1) infection; CESC cis rs12477438 0.520 rs4347885 chr2:99804007 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 12.28 0.6 9.55e-28 Chronic sinus infection; CESC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg19729930 chr2:74357872 NA 0.85 12.84 0.62 1.15e-29 Gestational age at birth (maternal effect); CESC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg18765753 chr7:1198926 ZFAND2A -0.39 -5.62 -0.33 4.77e-8 Longevity;Endometriosis; CESC cis rs3820928 0.874 rs11685983 chr2:227799853 A/G cg05526886 chr2:227700861 RHBDD1 -0.39 -5.07 -0.3 7.46e-7 Pulmonary function; CESC cis rs9346455 0.568 rs9354994 chr6:72030632 C/T cg27238071 chr6:71998145 OGFRL1 0.55 5.21 0.3 3.81e-7 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC trans rs61931739 0.500 rs11053236 chr12:34507962 C/G cg13010199 chr12:38710504 ALG10B 0.5 6.42 0.37 6.3e-10 Morning vs. evening chronotype; CESC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.61e-7 Blood metabolite levels; CESC cis rs1256061 0.624 rs1152586 chr14:64690784 T/C cg21174375 chr14:64681225 SYNE2 0.49 6.43 0.37 5.95e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24511898 chr2:242576823 ATG4B;THAP4 0.46 6.3 0.36 1.26e-9 Gut microbiota (bacterial taxa); CESC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg00080972 chr5:178986291 RUFY1 0.37 5.61 0.33 5.16e-8 Lung cancer; CESC cis rs34779708 0.931 rs35388511 chr10:35296616 A/G cg04310649 chr10:35416472 CREM -0.49 -5.93 -0.34 9.63e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs17384381 0.634 rs11801146 chr1:85915374 C/T cg16011679 chr1:85725395 C1orf52 0.66 6.65 0.38 1.63e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6424115 0.800 rs4649123 chr1:24197696 A/G cg15997130 chr1:24165203 NA 0.4 5.25 0.31 3.1e-7 Immature fraction of reticulocytes; CESC cis rs155076 0.666 rs9509640 chr13:21872880 T/C cg25811766 chr13:21894605 NA 0.54 5.41 0.32 1.39e-7 White matter hyperintensity burden; CESC cis rs72627123 0.867 rs74395411 chr14:74478584 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.63 0.33 4.49e-8 Morning vs. evening chronotype; CESC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg00166722 chr3:10149974 C3orf24 0.5 6.31 0.36 1.19e-9 Alzheimer's disease; CESC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg06873352 chr17:61820015 STRADA -0.6 -9.63 -0.51 5.11e-19 Prudent dietary pattern; CESC trans rs7937682 0.889 rs1789359 chr11:111475995 T/A cg18187862 chr3:45730750 SACM1L 0.48 6.11 0.35 3.49e-9 Primary sclerosing cholangitis; CESC cis rs870825 0.550 rs35981185 chr4:185639720 A/C cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC cis rs7833986 0.501 rs72653917 chr8:56892844 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.16 0.4 8.04e-12 Height; CESC trans rs6089829 1.000 rs6089829 chr20:61669036 C/T cg23505145 chr19:12996616 KLF1 -0.54 -7.03 -0.4 1.7e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs7551222 0.752 rs11240754 chr1:204477977 A/G cg20240347 chr1:204465584 NA -0.28 -5.61 -0.33 5.15e-8 Schizophrenia; CESC cis rs7847628 0.587 rs1060817 chr9:123583192 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 7.78 0.43 1.61e-13 Birth weight; CESC cis rs9911578 0.967 rs302842 chr17:56728102 C/G cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.59 0.32 5.76e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6762 0.692 rs7928925 chr11:839155 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.68 -8.44 -0.46 2.13e-15 Mean platelet volume; CESC cis rs7937682 0.575 rs7107213 chr11:111750430 A/G cg09085632 chr11:111637200 PPP2R1B 0.92 12.4 0.61 3.78e-28 Primary sclerosing cholangitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07355262 chr7:5347698 TNRC18 -0.39 -6.01 -0.35 6.09e-9 Gut microbiota (bacterial taxa); CESC trans rs11098499 0.863 rs7669520 chr4:120515278 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.26 0.49 7.05e-18 Corneal astigmatism; CESC cis rs1018836 0.886 rs10283086 chr8:91616651 G/A cg16814680 chr8:91681699 NA -0.76 -11.84 -0.59 3.08e-26 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs17376456 0.825 rs10075217 chr5:93176774 C/G cg25358565 chr5:93447407 FAM172A 1.06 10.37 0.54 2.34e-21 Diabetic retinopathy; CESC cis rs1006703 0.544 rs35443604 chr17:3833972 G/A cg06463185 chr17:3833770 ATP2A3 -0.54 -5.89 -0.34 1.18e-8 Glucose homeostasis traits; CESC cis rs1729951 0.545 rs1097288 chr3:136693721 C/T cg25687071 chr3:136751404 NA 0.39 5.19 0.3 4.27e-7 Neuroticism; CESC cis rs7560272 0.501 rs4852978 chr2:73943110 G/A cg20560298 chr2:73613845 ALMS1 0.41 5.69 0.33 3.43e-8 Schizophrenia; CESC cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg20476274 chr7:133979776 SLC35B4 0.67 9.8 0.52 1.45e-19 Mean platelet volume; CESC cis rs9308731 0.556 rs10166773 chr2:111936935 G/T cg04202892 chr2:111875749 ACOXL 0.37 5.18 0.3 4.34e-7 Chronic lymphocytic leukemia; CESC cis rs9814567 1.000 rs7433991 chr3:134312292 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.44 -0.32 1.21e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7959452 0.640 rs12370042 chr12:69692420 C/G cg14784868 chr12:69753453 YEATS4 0.74 10.68 0.55 2.15e-22 Blood protein levels; CESC cis rs11098499 0.954 rs7687843 chr4:120421211 C/T cg24375607 chr4:120327624 NA 0.46 5.64 0.33 4.3e-8 Corneal astigmatism; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11884792 chr2:192542902 OBFC2A -0.46 -6.05 -0.35 4.99e-9 Asthma; CESC cis rs3806843 0.735 rs778595 chr5:140036681 G/A cg26395211 chr5:140044315 WDR55 0.48 6.19 0.36 2.27e-9 Depressive symptoms (multi-trait analysis); CESC cis rs2832191 0.903 rs11700687 chr21:30486767 A/G cg24692254 chr21:30365293 RNF160 -0.73 -10.87 -0.56 5.11e-23 Dental caries; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09138430 chr7:44084267 DBNL -0.46 -6.05 -0.35 4.98e-9 Ulcerative colitis; CESC cis rs35110281 0.807 rs28840140 chr21:45039163 T/C cg21573476 chr21:45109991 RRP1B -0.46 -6.38 -0.37 7.77e-10 Mean corpuscular volume; CESC cis rs6688363 0.943 rs1016732 chr1:160086968 A/G cg22802111 chr1:160068614 IGSF8 0.52 5.17 0.3 4.65e-7 Response to antipsychotic treatment; CESC cis rs881375 0.933 rs4837804 chr9:123705304 C/G cg14580859 chr9:123691850 NA 0.28 5.12 0.3 5.88e-7 Rheumatoid arthritis; CESC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.26 -0.49 7.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg11764359 chr7:65958608 NA -0.93 -14.62 -0.67 6.62e-36 Aortic root size; CESC trans rs61931739 0.534 rs11053047 chr12:34161084 C/T cg26384229 chr12:38710491 ALG10B 0.64 9.08 0.49 2.54e-17 Morning vs. evening chronotype; CESC cis rs8064299 0.967 rs3744208 chr17:72767565 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.65 9.3 0.5 5.28e-18 Monocyte count; CESC cis rs1728785 0.901 rs12929568 chr16:68596689 A/G cg02972257 chr16:68554789 NA -0.51 -6.05 -0.35 4.98e-9 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09928813 chr16:30794679 ZNF629 0.48 6.73 0.38 1.06e-10 Fibrinogen levels; CESC cis rs45535039 1.000 rs11217194 chr11:119097568 T/C cg16724696 chr11:118992527 HINFP 0.42 5.28 0.31 2.69e-7 Plateletcrit; CESC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg06505273 chr16:24850292 NA 0.54 6.51 0.37 3.66e-10 Intelligence (multi-trait analysis); CESC cis rs9329289 0.888 rs11251273 chr10:2540300 G/C cg15501526 chr10:2543763 NA 0.63 11.27 0.57 2.43e-24 Age-related hearing impairment; CESC cis rs854765 0.583 rs8073001 chr17:17831716 A/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.53 -6.98 -0.39 2.41e-11 Total body bone mineral density; CESC cis rs425277 1.000 rs381664 chr1:2088104 A/G cg24578937 chr1:2090814 PRKCZ 0.55 9.47 0.5 1.63e-18 Height; CESC trans rs2727020 0.930 rs1164688 chr11:49290604 C/G cg15704280 chr7:45808275 SEPT13 0.8 11.17 0.57 5.5e-24 Coronary artery disease; CESC cis rs2880765 0.835 rs2170735 chr15:86043485 G/A cg19183879 chr15:85880815 NA -0.25 -5.1 -0.3 6.47e-7 Coronary artery disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06348081 chr3:182511312 ATP11B -0.49 -6.27 -0.36 1.45e-9 Asthma; CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg12419862 chr22:24373484 LOC391322 -0.9 -13.91 -0.65 2.15e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs72781680 0.898 rs72798041 chr2:23953076 T/C cg20701182 chr2:24300061 SF3B14 0.77 6.7 0.38 1.28e-10 Lymphocyte counts; CESC cis rs10197940 0.624 rs6724796 chr2:152412813 C/T cg06191203 chr2:152266755 RIF1 -0.44 -5.56 -0.32 6.44e-8 Lung cancer; CESC cis rs412050 0.502 rs8136405 chr22:22148021 A/C cg17089214 chr22:22089827 YPEL1 0.69 5.8 0.34 1.85e-8 Attention deficit hyperactivity disorder; CESC cis rs16854884 0.526 rs7643341 chr3:143726980 C/T cg01302019 chr3:143689584 C3orf58 -0.38 -5.94 -0.34 9.06e-9 Economic and political preferences (feminism/equality); CESC cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg02079420 chr8:82753780 SNX16 -0.53 -8.2 -0.45 1.01e-14 Diastolic blood pressure; CESC cis rs9303401 0.527 rs34835800 chr17:56764990 G/A cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.47 0.61 2.14e-28 Cognitive test performance; CESC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.69 6.11 0.35 3.54e-9 Platelet count; CESC cis rs1355223 0.867 rs2281908 chr11:34683578 C/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.25 -0.36 1.61e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg08470875 chr2:26401718 FAM59B 0.48 5.74 0.33 2.59e-8 Gut microbiome composition (summer); CESC cis rs61931739 0.817 rs10772144 chr12:34242463 A/C cg19457237 chr12:34500585 NA -0.42 -5.79 -0.33 2.01e-8 Morning vs. evening chronotype; CESC cis rs1707322 0.682 rs28508523 chr1:46189625 G/A cg06784218 chr1:46089804 CCDC17 0.42 7.58 0.42 5.82e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs453301 0.571 rs330054 chr8:9088291 G/A cg17143192 chr8:8559678 CLDN23 -0.44 -5.34 -0.31 1.99e-7 Joint mobility (Beighton score); CESC cis rs35146811 0.844 rs4729576 chr7:99692594 G/A cg13334819 chr7:99746414 C7orf59 -0.44 -5.19 -0.3 4.13e-7 Coronary artery disease; CESC cis rs7829975 0.617 rs4841071 chr8:8791144 G/T cg06636001 chr8:8085503 FLJ10661 0.41 5.18 0.3 4.46e-7 Mood instability; CESC cis rs4889855 0.578 rs7216808 chr17:78484187 A/G cg16591659 chr17:78472290 NA -0.51 -7.57 -0.42 6.27e-13 Fractional excretion of uric acid; CESC cis rs7851660 0.874 rs7868534 chr9:100632606 G/A cg13688889 chr9:100608707 NA -0.6 -8.55 -0.47 9.84e-16 Strep throat; CESC cis rs1506636 0.708 rs7788702 chr7:123237421 C/T cg03229431 chr7:123269106 ASB15 0.38 5.13 0.3 5.71e-7 Plateletcrit;Platelet count; CESC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg13628971 chr7:2884303 GNA12 0.64 8.78 0.47 2.11e-16 Height; CESC cis rs9303401 0.659 rs12952325 chr17:56899371 G/A cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.68 0.61 4.11e-29 Cognitive test performance; CESC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg27572855 chr1:25598939 RHD -0.43 -7.24 -0.41 4.99e-12 Erythrocyte sedimentation rate; CESC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.41 -6.06 -0.35 4.7e-9 Total body bone mineral density; CESC cis rs8072100 0.790 rs1962307 chr17:45707871 A/G cg08085267 chr17:45401833 C17orf57 -0.45 -5.65 -0.33 4.17e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs798554 0.704 rs798513 chr7:2782493 C/T cg19717773 chr7:2847554 GNA12 -0.55 -8.64 -0.47 5.3e-16 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11204671 chr14:24583351 DCAF11 0.53 6.05 0.35 5.02e-9 Gut microbiome composition (summer); CESC trans rs10242455 0.702 rs73403290 chr7:99157828 C/T cg09045935 chr12:6379348 NA 0.92 7.54 0.42 7.67e-13 Blood metabolite levels; CESC cis rs28498503 0.573 rs9945815 chr18:76654224 A/G cg00806245 chr18:76673096 NA -0.69 -5.66 -0.33 3.92e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs965469 0.947 rs6051773 chr20:3330382 C/G cg25506879 chr20:3388711 C20orf194 -0.54 -5.78 -0.33 2.14e-8 IFN-related cytopenia; CESC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg08027265 chr7:2291960 NA -0.4 -5.81 -0.34 1.78e-8 Bipolar disorder and schizophrenia; CESC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg02353165 chr6:42928485 GNMT 0.81 12.31 0.6 7.7e-28 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9346455 0.614 rs1322759 chr6:72013023 A/G cg27238071 chr6:71998145 OGFRL1 0.64 6.17 0.35 2.52e-9 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg06219351 chr7:158114137 PTPRN2 -0.5 -7.84 -0.43 1.1e-13 Calcium levels; CESC trans rs12681287 0.547 rs9942793 chr8:87509091 C/T cg27317242 chr8:23145699 R3HCC1 -0.53 -6.35 -0.36 9.05e-10 Caudate activity during reward; CESC cis rs12130219 1.000 rs34428306 chr1:152184316 G/C cg17718321 chr1:152188247 HRNR 0.41 5.53 0.32 7.77e-8 Inflammatory skin disease; CESC cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs80282103 0.618 rs11250249 chr10:1116999 T/C cg08668510 chr10:1095578 IDI1 0.83 5.06 0.3 7.71e-7 Glomerular filtration rate (creatinine); CESC cis rs1729951 0.575 rs35289288 chr3:136680568 C/T cg04103450 chr3:136751342 NA 0.4 5.28 0.31 2.67e-7 Neuroticism; CESC cis rs7107174 1.000 rs2510048 chr11:77987464 T/C cg02023728 chr11:77925099 USP35 0.48 6.63 0.38 1.82e-10 Testicular germ cell tumor; CESC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg18876405 chr7:65276391 NA -0.5 -6.78 -0.38 7.91e-11 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00746487 chr13:99293520 NA -0.54 -6.29 -0.36 1.3e-9 Gut microbiome composition (summer); CESC cis rs1670533 1.000 rs652063 chr4:1084137 T/C cg27284194 chr4:1044797 NA 0.48 6.17 0.35 2.6e-9 Recombination rate (females); CESC cis rs1256061 0.646 rs1256059 chr14:64710417 A/G cg21174375 chr14:64681225 SYNE2 0.49 6.68 0.38 1.43e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.84 0.48 1.34e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg10792982 chr14:105748885 BRF1 0.41 5.26 0.31 2.96e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7000551 0.681 rs2461488 chr8:22371858 G/A cg12081754 chr8:22256438 SLC39A14 0.38 5.11 0.3 6.32e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg10150615 chr22:24372951 LOC391322 -0.61 -8.37 -0.46 3.35e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg24531977 chr5:56204891 C5orf35 -0.5 -6.01 -0.35 6.01e-9 Coronary artery disease; CESC cis rs959260 1.000 rs4789193 chr17:73404796 A/T cg12999837 chr17:73267436 MIF4GD 0.48 5.46 0.32 1.07e-7 Systemic lupus erythematosus; CESC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg21856205 chr7:94953877 PON1 -0.43 -6.97 -0.39 2.59e-11 Paraoxonase activity; CESC cis rs4561483 0.801 rs40311 chr16:11963190 C/G cg08843971 chr16:11963173 GSPT1 0.57 8.58 0.47 7.98e-16 Testicular germ cell tumor; CESC cis rs12079745 0.590 rs12065030 chr1:169258201 A/G cg09363564 chr1:169337483 NME7;BLZF1 0.91 5.87 0.34 1.29e-8 QT interval; CESC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs8020095 0.528 rs6573724 chr14:67240565 T/C cg19548862 chr14:67692701 FAM71D -0.49 -5.97 -0.34 7.66e-9 Depression (quantitative trait); CESC cis rs4423214 0.840 rs4435028 chr11:71183690 C/A cg05163923 chr11:71159392 DHCR7 -0.68 -7.76 -0.43 1.82e-13 Vitamin D levels; CESC cis rs2594989 0.943 rs2594970 chr3:11400877 C/T cg00170343 chr3:11313890 ATG7 0.55 5.03 0.3 9.09e-7 Circulating chemerin levels; CESC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg06808227 chr14:105710500 BRF1 -0.58 -6.77 -0.38 8.26e-11 Mean platelet volume;Platelet distribution width; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg09033563 chr22:24373618 LOC391322 -0.45 -5.76 -0.33 2.29e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg02564969 chr6:151773285 C6orf211;RMND1 0.62 8.49 0.46 1.51e-15 Menarche (age at onset); CESC trans rs982100 0.596 rs933759 chr2:118469325 C/T cg24863536 chr7:75889570 SRRM3 0.76 6.07 0.35 4.35e-9 Alzheimer disease and age of onset; CESC cis rs8017423 0.967 rs61592400 chr14:90703252 T/C cg14092571 chr14:90743983 NA -0.57 -8.44 -0.46 2.09e-15 Mortality in heart failure; CESC cis rs6812193 0.518 rs7662031 chr4:77205338 T/C cg20311846 chr4:77356250 SHROOM3 -0.31 -5.58 -0.32 5.82e-8 Parkinson's disease; CESC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg21747405 chr11:67723411 NA -0.44 -6.69 -0.38 1.3100000000000001e-10 Blood pressure (smoking interaction); CESC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg19468946 chr17:37922297 IKZF3 0.41 5.22 0.31 3.59e-7 Glomerular filtration rate (creatinine); CESC cis rs8180040 0.966 rs2291298 chr3:47555142 C/A cg27129171 chr3:47204927 SETD2 0.59 8.48 0.46 1.57e-15 Colorectal cancer; CESC cis rs1355223 0.902 rs12801509 chr11:34747336 G/T cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.08 -0.35 4.14e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs853679 0.545 rs35949109 chr6:28025926 T/C cg18032046 chr6:28092343 ZSCAN16 -0.67 -5.12 -0.3 5.9e-7 Depression; CESC cis rs8017423 1.000 rs2183189 chr14:90670057 A/G cg14092571 chr14:90743983 NA -0.56 -8.28 -0.45 5.95e-15 Mortality in heart failure; CESC cis rs4423214 0.840 rs1792224 chr11:71176141 C/T cg05163923 chr11:71159392 DHCR7 -0.65 -7.55 -0.42 6.91e-13 Vitamin D levels; CESC cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.87 0.34 1.31e-8 Tonsillectomy; CESC cis rs9311474 0.713 rs352165 chr3:52242902 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.32 5.75 0.33 2.47e-8 Electroencephalogram traits; CESC cis rs7647973 0.710 rs2029591 chr3:49646981 C/T cg13072238 chr3:49761600 GMPPB 0.51 5.93 0.34 9.53e-9 Menarche (age at onset); CESC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg24562669 chr7:97807699 LMTK2 0.48 7.01 0.4 1.98e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs11514810 1.000 rs9648619 chr7:1427949 G/T cg24899294 chr7:1481343 MICALL2 -0.69 -5.78 -0.33 2.07e-8 Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder; CESC cis rs7044106 0.762 rs1547267 chr9:123408736 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.14 0.3 5.26e-7 Hip circumference adjusted for BMI; CESC cis rs6540556 0.608 rs7548781 chr1:209915795 A/G cg05527609 chr1:210001259 C1orf107 0.57 6.67 0.38 1.5e-10 Red blood cell count; CESC cis rs9488822 0.636 rs10872142 chr6:116369052 C/A cg26893134 chr6:116381904 FRK 0.25 6.08 0.35 4.07e-9 Cholesterol, total;LDL cholesterol; CESC cis rs79349575 0.721 rs9904645 chr17:46969665 A/T cg16584676 chr17:46985605 UBE2Z 0.54 6.62 0.38 2.03e-10 Type 2 diabetes; CESC cis rs1707322 0.717 rs1135850 chr1:46093692 G/A cg03146154 chr1:46216737 IPP 0.79 11.05 0.56 1.36e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7618501 0.633 rs6771546 chr3:49968572 T/C cg21659725 chr3:3221576 CRBN 0.49 6.8 0.39 6.8e-11 Intelligence (multi-trait analysis); CESC trans rs3942852 0.712 rs2174129 chr11:48108557 A/C cg15704280 chr7:45808275 SEPT13 -0.73 -8.8 -0.48 1.75e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg15112475 chr7:1198522 ZFAND2A -0.38 -5.96 -0.34 8.22e-9 Longevity;Endometriosis; CESC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg18758796 chr5:131593413 PDLIM4 0.38 5.07 0.3 7.43e-7 Blood metabolite levels; CESC cis rs6598955 0.670 rs10794525 chr1:26537193 C/A cg04990556 chr1:26633338 UBXN11 -0.75 -10.63 -0.55 3.15e-22 Obesity-related traits; CESC cis rs9487051 0.768 rs351742 chr6:109527325 C/T cg01475377 chr6:109611718 NA 0.43 6.44 0.37 5.44e-10 Reticulocyte fraction of red cells; CESC cis rs7193541 0.684 rs9923145 chr16:74686166 G/A cg01733217 chr16:74700730 RFWD3 1.05 20.17 0.78 1.79e-55 Multiple myeloma; CESC cis rs2228479 0.702 rs11076621 chr16:89837927 A/G cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg12311346 chr5:56204834 C5orf35 -0.57 -7.57 -0.42 6.09e-13 Coronary artery disease; CESC trans rs7937682 0.924 rs875257 chr11:111530453 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.08 0.35 4.15e-9 Primary sclerosing cholangitis; CESC cis rs78366141 0.536 rs78517451 chr4:89650437 C/A cg01026744 chr4:89619053 NAP1L5;HERC3 0.86 5.39 0.31 1.56e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs9911578 0.967 rs12944948 chr17:56951474 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.17 0.3 4.57e-7 Intelligence (multi-trait analysis); CESC cis rs9287719 0.967 rs1541573 chr2:10773385 T/G cg02196655 chr2:10830764 NOL10 -0.36 -5.36 -0.31 1.79e-7 Prostate cancer; CESC cis rs1707322 0.963 rs4508055 chr1:46257731 A/T cg03146154 chr1:46216737 IPP 0.8 11.02 0.56 1.72e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2901656 0.502 rs9425602 chr1:172383686 T/A cg03748243 chr1:172413542 C1orf105;PIGC -0.38 -5.18 -0.3 4.43e-7 Red cell distribution width;Platelet distribution width; CESC cis rs6963495 0.818 rs75116202 chr7:105160059 C/T cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs7312774 0.881 rs79048355 chr12:107311169 G/T cg16260113 chr12:107380972 MTERFD3 0.64 6.08 0.35 4.08e-9 Severe influenza A (H1N1) infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14633757 chr17:80231324 CSNK1D -0.47 -6.36 -0.36 8.78e-10 Fibrinogen levels; CESC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg11644478 chr21:40555479 PSMG1 1.04 16.98 0.72 2.99e-44 Cognitive function; CESC cis rs67311347 0.910 rs7651204 chr3:40512835 C/T cg24209194 chr3:40518798 ZNF619 -0.53 -6.88 -0.39 4.25e-11 Renal cell carcinoma; CESC cis rs11098499 0.722 rs28713555 chr4:120251995 C/T cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg00166722 chr3:10149974 C3orf24 0.46 5.94 0.34 9.04e-9 Alzheimer's disease; CESC cis rs672059 1.000 rs510642 chr1:183162776 A/C ch.1.3577855R chr1:183094577 LAMC1 0.56 7.17 0.4 7.56e-12 Hypertriglyceridemia; CESC cis rs8070624 0.502 rs12951376 chr17:17752809 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.45 5.93 0.34 9.52e-9 Total body bone mineral density; CESC cis rs6088580 0.584 rs2378203 chr20:32993846 A/T cg24642439 chr20:33292090 TP53INP2 -0.53 -6.98 -0.39 2.31e-11 Glomerular filtration rate (creatinine); CESC cis rs11760633 0.607 rs11760284 chr7:1827569 C/T cg23422044 chr7:1970798 MAD1L1 -0.43 -5.14 -0.3 5.27e-7 Coronary artery disease; CESC cis rs41271951 0.558 rs79671334 chr1:151115887 C/G cg11822372 chr1:151115635 SEMA6C -0.87 -6.23 -0.36 1.83e-9 Blood protein levels; CESC cis rs9549260 0.876 rs9549258 chr13:41248026 T/C cg21288729 chr13:41239152 FOXO1 0.62 5.89 0.34 1.15e-8 Red blood cell count; CESC cis rs5753618 0.504 rs5753661 chr22:31899797 C/A cg00478049 chr22:31556069 RNF185 -0.46 -5.53 -0.32 7.55e-8 Colorectal cancer; CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.53 7.73 0.43 2.19e-13 Bipolar disorder; CESC cis rs7845219 0.544 rs4735330 chr8:95917770 A/C cg16049864 chr8:95962084 TP53INP1 -0.49 -7.22 -0.41 5.48e-12 Type 2 diabetes; CESC cis rs722599 0.748 rs17102884 chr14:75374899 C/T cg08847533 chr14:75593920 NEK9 -0.45 -5.47 -0.32 1.02e-7 IgG glycosylation; CESC trans rs8073060 0.586 rs226087 chr17:34017652 T/C cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs4253772 0.591 rs6007795 chr22:46686792 C/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.55 5.66 0.33 3.89e-8 LDL cholesterol;Cholesterol, total; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09225973 chr6:150232183 NA -0.46 -6.45 -0.37 5.35e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs35110281 0.666 rs2838348 chr21:45107285 C/G cg01579765 chr21:45077557 HSF2BP 0.51 8.54 0.46 1.09e-15 Mean corpuscular volume; CESC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg10295955 chr4:187884368 NA -1.08 -23.24 -0.82 6.56e-66 Lobe attachment (rater-scored or self-reported); CESC cis rs116095464 0.558 rs73029475 chr5:206969 T/C cg16372103 chr5:203701 NA 0.49 5.29 0.31 2.6e-7 Breast cancer; CESC cis rs1707322 1.000 rs6675222 chr1:46326576 G/T cg03146154 chr1:46216737 IPP 0.72 9.91 0.52 6.71e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.91e-10 Bipolar disorder; CESC cis rs9400271 0.632 rs6899616 chr6:109584885 A/G cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10211485 chr17:655108 ELP2P;GEMIN4 -0.45 -6.13 -0.35 3.18e-9 Asthma; CESC cis rs2688608 0.592 rs11814282 chr10:75490217 T/C cg23231163 chr10:75533350 FUT11 -0.35 -5.27 -0.31 2.81e-7 Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08914378 chr7:98923334 ARPC1A 0.58 7.09 0.4 1.25e-11 Gut microbiome composition (summer); CESC trans rs1814175 0.519 rs10839291 chr11:49514321 G/A cg03929089 chr4:120376271 NA 0.68 7.7 0.43 2.66e-13 Height; CESC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg02891314 chr5:179741120 GFPT2 -0.58 -7.86 -0.43 1e-13 Height; CESC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg18876405 chr7:65276391 NA -0.54 -7.06 -0.4 1.46e-11 Aortic root size; CESC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs3768617 0.510 rs3818417 chr1:183079376 G/A ch.1.3577855R chr1:183094577 LAMC1 0.88 14.14 0.66 3.44e-34 Fuchs's corneal dystrophy; CESC trans rs66573146 1.000 rs66519732 chr4:6990569 C/G cg07817883 chr1:32538562 TMEM39B 1.33 7.93 0.44 6.25e-14 Granulocyte percentage of myeloid white cells; CESC cis rs8028182 0.636 rs8029112 chr15:75808972 T/C cg20655648 chr15:75932815 IMP3 0.48 5.91 0.34 1.06e-8 Sudden cardiac arrest; CESC cis rs2742234 0.955 rs1800861 chr10:43613843 G/T cg15436174 chr10:43711423 RASGEF1A -0.4 -5.11 -0.3 6.04e-7 Hirschsprung disease; CESC cis rs10504229 0.679 rs7840100 chr8:58036662 T/G cg24829409 chr8:58192753 C8orf71 -0.46 -5.83 -0.34 1.59e-8 Developmental language disorder (linguistic errors); CESC cis rs1538970 0.961 rs4660854 chr1:45854087 A/T cg05343316 chr1:45956843 TESK2 0.8 11.55 0.58 2.96e-25 Platelet count; CESC cis rs11098499 0.954 rs28685688 chr4:120420334 T/C cg24375607 chr4:120327624 NA 0.46 5.61 0.33 5.16e-8 Corneal astigmatism; CESC trans rs7937682 0.889 rs497111 chr11:111499512 G/A cg18187862 chr3:45730750 SACM1L 0.51 6.5 0.37 3.97e-10 Primary sclerosing cholangitis; CESC cis rs9549260 0.564 rs4245402 chr13:41287540 C/T cg21288729 chr13:41239152 FOXO1 0.58 7.81 0.43 1.36e-13 Red blood cell count; CESC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg05863683 chr7:1912471 MAD1L1 0.45 6.87 0.39 4.55e-11 Bipolar disorder and schizophrenia; CESC cis rs4588572 0.643 rs1019739 chr5:77770241 G/C cg11547950 chr5:77652471 NA -0.45 -5.63 -0.33 4.53e-8 Triglycerides; CESC cis rs748404 0.697 rs546722 chr15:43580819 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.54 8.49 0.46 1.51e-15 Lung cancer; CESC cis rs11098499 0.691 rs10010355 chr4:120261043 A/G cg09307838 chr4:120376055 NA 0.76 10.31 0.54 3.54e-21 Corneal astigmatism; CESC cis rs11997175 0.646 rs7005018 chr8:33700210 A/G ch.8.33884649F chr8:33765107 NA 0.56 7.34 0.41 2.56e-12 Body mass index; CESC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.08 0.79 1.35e-58 Prudent dietary pattern; CESC trans rs7319075 0.657 rs9533543 chr13:44173400 A/G cg03952484 chr1:149899818 SF3B4 0.5 6.19 0.36 2.3e-9 Photic sneeze reflex; CESC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 12.96 0.62 4.51e-30 Platelet count; CESC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg18099408 chr3:52552593 STAB1 -0.3 -5.05 -0.3 8.22e-7 Bipolar disorder; CESC cis rs1055129 0.516 rs7218498 chr17:73931847 C/G cg08125733 chr17:73851984 WBP2 0.51 7.05 0.4 1.51e-11 White matter hyperintensity burden; CESC cis rs2066819 1.000 rs11575231 chr12:56744445 T/C cg26734620 chr12:56694298 CS 0.98 5.94 0.34 8.73e-9 Psoriasis vulgaris; CESC cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg05340658 chr4:99064831 C4orf37 0.83 12.91 0.62 6.52e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7089973 0.604 rs61596353 chr10:116597763 T/C cg03647239 chr10:116582469 FAM160B1 0.44 5.55 0.32 6.83e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg18876405 chr7:65276391 NA 0.7 9.83 0.52 1.18e-19 Aortic root size; CESC cis rs933688 1.000 rs1895448 chr5:90743854 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.9 11.74 0.58 6.72e-26 Smoking behavior; CESC cis rs1003719 0.667 rs8127148 chr21:38481292 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.61 8.02 0.44 3.44e-14 Eye color traits; CESC cis rs1421811 0.606 rs62369523 chr5:32713365 T/G cg16267343 chr5:32710456 NPR3 0.57 6.16 0.35 2.73e-9 Blood pressure; CESC cis rs454510 0.726 rs376910 chr1:120181277 A/C cg16322792 chr1:120165303 ZNF697 -0.4 -6.62 -0.38 2.04e-10 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg17330251 chr7:94953956 PON1 -0.65 -9.86 -0.52 9.59e-20 Paraoxonase activity; CESC cis rs7520050 0.966 rs11211241 chr1:46452683 T/A cg24296786 chr1:45957014 TESK2 0.44 5.5 0.32 8.98e-8 Red blood cell count;Reticulocyte count; CESC cis rs9479482 0.678 rs3903885 chr6:150364128 G/A cg03788504 chr6:150331562 NA -0.36 -6.99 -0.39 2.17e-11 Alopecia areata; CESC cis rs854765 0.506 rs7210400 chr17:17949957 C/T cg16928487 chr17:17741425 SREBF1 0.57 9.8 0.52 1.45e-19 Total body bone mineral density; CESC cis rs1784581 0.588 rs9346894 chr6:162430763 T/C cg17173639 chr6:162384350 PARK2 0.56 8.46 0.46 1.87e-15 Itch intensity from mosquito bite; CESC cis rs1983891 0.643 rs3800284 chr6:41558365 G/C cg20194872 chr6:41519635 FOXP4 0.45 6.3 0.36 1.22e-9 Prostate cancer; CESC cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg22764044 chr5:178986830 RUFY1 0.45 6.78 0.38 7.76e-11 Lung cancer; CESC cis rs3749237 0.576 rs4241406 chr3:49600426 C/T cg03060546 chr3:49711283 APEH 0.77 11.73 0.58 7.34e-26 Resting heart rate; CESC cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg05340658 chr4:99064831 C4orf37 0.69 9.46 0.5 1.69e-18 Colonoscopy-negative controls vs population controls; CESC cis rs55788414 0.932 rs8048115 chr16:81182554 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -7.02 -0.4 1.84e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs12681366 0.647 rs12545262 chr8:95405041 C/T cg13257157 chr8:95487014 RAD54B 0.39 5.21 0.3 3.82e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs11792861 0.816 rs2275637 chr9:111696043 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.53 6.77 0.38 8.2e-11 Menarche (age at onset); CESC cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg00409905 chr10:38381863 ZNF37A -0.45 -6.0 -0.35 6.61e-9 Extrinsic epigenetic age acceleration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22584335 chr2:27806067 ZNF512 -0.41 -6.07 -0.35 4.4e-9 Gambling; CESC cis rs2455799 0.613 rs4685260 chr3:15832417 C/T cg16303742 chr3:15540471 COLQ -0.41 -6.22 -0.36 1.88e-9 Mean platelet volume; CESC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -11.0 -0.56 1.9e-23 Alzheimer's disease; CESC cis rs2075371 0.966 rs2544225 chr7:133995838 A/C cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 2.99e-8 Mean platelet volume; CESC cis rs3820928 0.874 rs1917123 chr2:227889783 T/G cg05526886 chr2:227700861 RHBDD1 -0.41 -5.12 -0.3 5.78e-7 Pulmonary function; CESC cis rs950169 0.881 rs34117475 chr15:85108443 T/C cg17507749 chr15:85114479 UBE2QP1 0.55 6.18 0.35 2.42e-9 Schizophrenia; CESC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.77 11.05 0.56 1.35e-23 Age-related macular degeneration (geographic atrophy); CESC trans rs9929218 0.581 rs7203337 chr16:68774800 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.88 14.99 0.68 3.36e-37 Colorectal cancer; CESC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg00409905 chr10:38381863 ZNF37A -0.45 -5.96 -0.34 7.89e-9 Extrinsic epigenetic age acceleration; CESC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg13393036 chr8:95962371 TP53INP1 -0.48 -10.36 -0.54 2.51e-21 Type 2 diabetes; CESC cis rs9837602 1.000 rs35669453 chr3:99766063 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.56 0.42 6.43e-13 Breast cancer; CESC cis rs4727963 0.792 rs2402627 chr7:122728102 T/C cg03640110 chr7:122635026 TAS2R16 0.4 6.29 0.36 1.3e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.76 0.33 2.3e-8 Tonsillectomy; CESC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg18350739 chr11:68623251 NA -0.44 -6.98 -0.39 2.31e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6493487 0.512 rs2414054 chr15:51129827 A/G cg02338191 chr15:51200825 AP4E1 0.51 5.19 0.3 4.29e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs34891900 0.507 rs738133 chr22:18205557 C/T cg19898043 chr22:18121309 BCL2L13 0.56 6.73 0.38 1.02e-10 Sum neutrophil eosinophil counts; CESC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg22764044 chr5:178986830 RUFY1 0.38 5.49 0.32 9.45e-8 Lung cancer; CESC cis rs9926296 0.609 rs4785710 chr16:89796756 C/T cg04287289 chr16:89883240 FANCA -0.64 -8.66 -0.47 4.86e-16 Vitiligo; CESC cis rs10276381 0.892 rs7786444 chr7:28154384 C/T cg23620719 chr7:28220237 JAZF1 0.59 6.27 0.36 1.5e-9 Crohn's disease; CESC cis rs7927771 0.697 rs11039307 chr11:47611152 C/T cg20307385 chr11:47447363 PSMC3 -0.42 -5.18 -0.3 4.36e-7 Subjective well-being; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17578755 chr11:1299291 TOLLIP 0.38 6.11 0.35 3.48e-9 Fibrinogen levels; CESC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.71 11.36 0.57 1.22e-24 Personality dimensions; CESC cis rs2439831 0.867 rs2245176 chr15:43750762 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.57 0.54 5.08e-22 Lung cancer in ever smokers; CESC cis rs7605827 0.930 rs2160692 chr2:15637496 C/G cg19274914 chr2:15703543 NA 0.36 6.32 0.36 1.13e-9 Educational attainment (years of education); CESC cis rs67311347 1.000 rs6599102 chr3:40468406 G/A cg09455208 chr3:40491958 NA 0.44 7.5 0.42 9.61e-13 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23373626 chr5:141031295 FCHSD1 -0.62 -6.67 -0.38 1.53e-10 Gut microbiome composition (summer); CESC cis rs9291683 0.588 rs12647117 chr4:10022059 T/C cg11266682 chr4:10021025 SLC2A9 0.7 14.67 0.67 4.52e-36 Bone mineral density; CESC cis rs7264396 0.790 rs6060516 chr20:34214368 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.65 0.43 3.84e-13 Total cholesterol levels; CESC cis rs2204008 0.837 rs7301679 chr12:37989629 T/C cg26384229 chr12:38710491 ALG10B -0.55 -7.8 -0.43 1.39e-13 Bladder cancer; CESC trans rs5756813 0.754 rs4821708 chr22:38164106 C/T cg19894588 chr14:64061835 NA -0.69 -9.22 -0.49 9.91e-18 Optic cup area;Vertical cup-disc ratio; CESC cis rs6088580 0.634 rs6059850 chr20:33044784 C/G cg24642439 chr20:33292090 TP53INP2 0.53 7.1 0.4 1.11e-11 Glomerular filtration rate (creatinine); CESC cis rs9911578 0.967 rs405684 chr17:56777148 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.15 0.3 5.01e-7 Intelligence (multi-trait analysis); CESC cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.43 5.31 0.31 2.36e-7 Eosinophil percentage of white cells; CESC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg00815214 chr21:47717953 NA 0.36 5.31 0.31 2.36e-7 Testicular germ cell tumor; CESC cis rs10791097 0.547 rs1050078 chr11:130746146 T/C cg12179176 chr11:130786555 SNX19 0.68 10.08 0.53 1.97e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs10089 0.951 rs1864923 chr5:127420843 G/C cg19767477 chr5:127420684 SLC12A2 -0.41 -5.52 -0.32 7.88e-8 Ileal carcinoids; CESC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg11494091 chr17:61959527 GH2 0.71 11.59 0.58 2.1e-25 Prudent dietary pattern; CESC cis rs4595586 0.545 rs6580889 chr12:39369742 T/C cg26384229 chr12:38710491 ALG10B 0.49 7.0 0.4 2.1e-11 Morning vs. evening chronotype; CESC cis rs7809799 1.000 rs10266364 chr7:98764779 T/C cg05967295 chr7:98741636 SMURF1 -0.77 -5.41 -0.32 1.37e-7 Ulcerative colitis; CESC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg08704250 chr15:31115839 NA -0.63 -8.07 -0.44 2.48e-14 Huntington's disease progression; CESC trans rs11039798 0.528 rs10839208 chr11:49030456 C/T cg15704280 chr7:45808275 SEPT13 0.66 7.08 0.4 1.3e-11 Axial length; CESC cis rs6584283 0.713 rs1332100 chr10:101301346 C/T cg09788492 chr10:101292477 NKX2-3 -0.3 -5.17 -0.3 4.54e-7 Ulcerative colitis; CESC cis rs9902453 0.900 rs56195309 chr17:28453753 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 8.01 0.44 3.58e-14 Coffee consumption (cups per day); CESC cis rs11587400 0.656 rs6689415 chr1:115107469 G/T cg12756093 chr1:115239321 AMPD1 0.44 6.14 0.35 2.94e-9 Autism; CESC cis rs35110281 0.805 rs4818855 chr21:45038951 C/T cg04455712 chr21:45112962 RRP1B 0.4 6.2 0.36 2.16e-9 Mean corpuscular volume; CESC cis rs9828933 0.938 rs7617036 chr3:64002995 G/A cg16258503 chr3:63850278 ATXN7;THOC7 -0.52 -5.21 -0.3 3.74e-7 Type 2 diabetes; CESC cis rs7165102 1.000 rs12906196 chr15:65884888 T/C cg11441148 chr15:65824328 PTPLAD1 0.32 5.39 0.31 1.53e-7 Mean corpuscular hemoglobin; CESC cis rs858239 0.601 rs764533 chr7:23153875 C/T cg23682824 chr7:23144976 KLHL7 0.54 7.44 0.42 1.45e-12 Cerebrospinal fluid biomarker levels; CESC cis rs12410462 1.000 rs12410462 chr1:227667790 A/G cg04117972 chr1:227635322 NA -0.66 -6.58 -0.37 2.56e-10 Major depressive disorder; CESC cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg03709012 chr19:19516395 GATAD2A -0.99 -15.04 -0.68 2.25e-37 Tonsillectomy; CESC cis rs9790314 0.846 rs9815222 chr3:160994897 C/T cg03342759 chr3:160939853 NMD3 -0.51 -7.37 -0.41 2.23e-12 Morning vs. evening chronotype; CESC cis rs847577 0.550 rs12670686 chr7:97708397 A/G cg21770322 chr7:97807741 LMTK2 0.82 14.54 0.67 1.31e-35 Breast cancer; CESC cis rs7100689 0.622 rs7082093 chr10:82134954 T/G cg00277334 chr10:82204260 NA -0.58 -7.52 -0.42 8.77e-13 Post bronchodilator FEV1; CESC cis rs1153858 1.000 rs4775907 chr15:45638647 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs11676348 0.774 rs4672870 chr2:218941916 C/T cg00012203 chr2:219082015 ARPC2 -0.46 -5.73 -0.33 2.71e-8 Ulcerative colitis; CESC cis rs643506 1.000 rs643506 chr11:111636627 T/G cg17089665 chr11:111648010 NA -0.36 -5.05 -0.3 8.24e-7 Breast cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg22004443 chr2:10953237 PDIA6 -0.44 -6.2 -0.36 2.18e-9 Asthma; CESC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg08499158 chr17:42289980 UBTF -0.53 -6.66 -0.38 1.59e-10 Total body bone mineral density; CESC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg22508957 chr16:3507546 NAT15 0.57 9.5 0.5 1.31e-18 Tuberculosis; CESC cis rs2070677 0.935 rs4335491 chr10:135422460 T/G cg20169779 chr10:135381914 SYCE1 -0.74 -9.88 -0.52 8.58e-20 Gout; CESC cis rs116095464 0.558 rs57335027 chr5:262907 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.86e-15 Breast cancer; CESC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg06634786 chr22:41940651 POLR3H 0.58 6.31 0.36 1.14e-9 Vitiligo; CESC cis rs2732480 0.500 rs2732461 chr12:48692802 C/A cg24011408 chr12:48396354 COL2A1 0.42 5.86 0.34 1.4e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg16680214 chr1:154839983 KCNN3 0.36 5.34 0.31 2.02e-7 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05636869 chr5:52777880 FST 0.55 6.02 0.35 5.73e-9 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg06873352 chr17:61820015 STRADA 0.47 6.81 0.39 6.42e-11 Height; CESC cis rs7130144 0.541 rs73572230 chr11:130460843 G/A cg26307797 chr11:130446613 NA -0.8 -6.53 -0.37 3.43e-10 Urate levels in lean individuals; CESC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg02524346 chr8:600233 NA 0.83 6.81 0.39 6.47e-11 IgG glycosylation; CESC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg16325326 chr1:53192061 ZYG11B 0.61 9.29 0.5 5.81e-18 Monocyte count; CESC cis rs8072100 0.840 rs4968319 chr17:45464967 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -5.62 -0.33 4.91e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.12 0.3 5.96e-7 Colonoscopy-negative controls vs population controls; CESC cis rs75477785 0.590 rs72649937 chr1:210205055 C/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.91 6.32 0.36 1.09e-9 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07988989 chr2:120981274 TMEM185B -0.63 -7.16 -0.4 7.81e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02468154 chr11:43755634 HSD17B12 -0.5 -6.15 -0.35 2.88e-9 Gut microbiome composition (summer); CESC cis rs9291683 0.588 rs2240724 chr4:10021290 G/C cg00071950 chr4:10020882 SLC2A9 0.89 17.23 0.73 3.88e-45 Bone mineral density; CESC cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg00701064 chr4:6280414 WFS1 0.72 11.88 0.59 2.22e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6460942 0.915 rs10267801 chr7:12451931 G/A cg17427002 chr7:12443146 VWDE -0.46 -5.1 -0.3 6.52e-7 Coronary artery disease; CESC cis rs1941023 0.584 rs2233253 chr11:60157166 C/T cg08716584 chr11:60157161 MS4A7 -0.6 -10.18 -0.53 9e-21 Congenital heart disease (maternal effect); CESC cis rs977987 0.806 rs12917651 chr16:75466696 G/T cg03315344 chr16:75512273 CHST6 0.41 5.94 0.34 8.69e-9 Dupuytren's disease; CESC cis rs4849845 0.584 rs3896630 chr2:121037018 A/G cg24070213 chr2:121070622 NA 0.43 6.33 0.36 1.07e-9 Mean platelet volume; CESC cis rs11792861 0.926 rs118011482 chr9:111770626 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.49 6.18 0.35 2.4e-9 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22442180 chr1:1684399 NADK -0.48 -6.07 -0.35 4.53e-9 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs8079891 chr17:29058863 G/A cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.61 -0.33 4.97e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.712 rs11731393 chr4:98859070 G/C cg17366294 chr4:99064904 C4orf37 0.57 5.87 0.34 1.3e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 0.967 rs7502208 chr17:57165097 G/A cg05425664 chr17:57184151 TRIM37 -0.52 -7.23 -0.41 5.23e-12 Intelligence (multi-trait analysis); CESC cis rs66573146 0.831 rs67602077 chr4:7024244 A/G cg12726927 chr4:7941431 AFAP1 -0.88 -5.19 -0.3 4.26e-7 Granulocyte percentage of myeloid white cells; CESC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg05564831 chr3:52568323 NT5DC2 0.45 7.04 0.4 1.68e-11 Electroencephalogram traits; CESC cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg26597838 chr10:835615 NA 0.86 8.97 0.48 5.53e-17 Eosinophil percentage of granulocytes; CESC trans rs116095464 0.558 rs62347678 chr5:227496 A/G cg00938859 chr5:1591904 SDHAP3 0.61 6.75 0.38 9.06e-11 Breast cancer; CESC cis rs35110281 0.506 rs13051661 chr21:45111518 A/T cg01579765 chr21:45077557 HSF2BP -0.53 -8.87 -0.48 1.12e-16 Mean corpuscular volume; CESC cis rs4423214 0.765 rs2002064 chr11:71163420 A/G cg05163923 chr11:71159392 DHCR7 -0.63 -7.38 -0.41 2.01e-12 Vitamin D levels; CESC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs67460515 0.563 rs13256 chr3:160796505 G/A cg03342759 chr3:160939853 NMD3 -0.51 -6.25 -0.36 1.65e-9 Parkinson's disease; CESC cis rs3809863 0.646 rs9899121 chr17:45395144 C/T cg25173405 chr17:45401733 C17orf57 -0.54 -6.99 -0.39 2.17e-11 Glaucoma (primary open-angle); CESC cis rs2282802 0.685 rs10051345 chr5:139670932 C/G cg26211634 chr5:139558579 C5orf32 -0.49 -7.03 -0.4 1.72e-11 Intelligence (multi-trait analysis); CESC cis rs9399135 0.967 rs9389253 chr6:135329755 T/C cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs524281 1.000 rs475805 chr11:65848738 G/A cg14036092 chr11:66035641 RAB1B 0.53 6.04 0.35 5.32e-9 Electroencephalogram traits; CESC cis rs4148883 0.651 rs2851301 chr4:100010127 C/T cg13256891 chr4:100009986 ADH5 0.53 6.87 0.39 4.44e-11 Alcohol dependence; CESC trans rs11039798 0.623 rs6485879 chr11:48587984 G/T cg15704280 chr7:45808275 SEPT13 0.61 6.16 0.35 2.65e-9 Axial length; CESC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg25767906 chr1:53392781 SCP2 0.5 7.37 0.41 2.22e-12 Monocyte count; CESC cis rs9898189 1 rs9898189 chr17:80480516 C/G cg10255544 chr17:80519551 FOXK2 0.37 5.46 0.32 1.07e-7 Red cell distribution width; CESC cis rs4547160 0.821 rs951359 chr12:63482309 G/A cg26727693 chr12:63544175 AVPR1A -0.41 -5.67 -0.33 3.74e-8 Morning vs. evening chronotype; CESC cis rs3749237 0.595 rs7621003 chr3:49411404 T/C cg02487422 chr3:49467188 NICN1 0.55 7.98 0.44 4.56e-14 Resting heart rate; CESC cis rs11638352 0.661 rs2412855 chr15:44340480 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.65 -6.0 -0.35 6.43e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs7937682 0.889 rs487985 chr11:111517908 G/A cg22437258 chr11:111473054 SIK2 0.7 9.35 0.5 3.83e-18 Primary sclerosing cholangitis; CESC cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg23711669 chr6:146136114 FBXO30 -0.92 -12.44 -0.61 2.84e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs2425143 1.000 rs6058311 chr20:34321895 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.51 -0.42 9.02e-13 Blood protein levels; CESC cis rs1003719 0.680 rs2835620 chr21:38505581 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.47 -0.46 1.69e-15 Eye color traits; CESC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg10494973 chr17:80897199 TBCD -0.44 -5.3 -0.31 2.41e-7 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11118681 chr3:39149366 TTC21A;GORASP1 -0.48 -6.16 -0.35 2.65e-9 Ulcerative colitis; CESC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg05234568 chr11:5960015 NA -0.65 -8.8 -0.48 1.77e-16 DNA methylation (variation); CESC cis rs2952156 0.684 rs1877031 chr17:37814080 G/A cg20243544 chr17:37824526 PNMT 0.65 8.75 0.47 2.47e-16 Asthma; CESC cis rs2243480 1.000 rs35825738 chr7:65318027 A/G cg12463550 chr7:65579703 CRCP 0.68 5.73 0.33 2.72e-8 Diabetic kidney disease; CESC cis rs4319547 0.688 rs10847242 chr12:123079020 T/G cg05707623 chr12:122985044 ZCCHC8 -0.43 -5.36 -0.31 1.77e-7 Body mass index; CESC cis rs6502050 0.835 rs35070385 chr17:80128447 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.97e-7 Life satisfaction; CESC cis rs1008375 1.000 rs4698648 chr4:17692715 C/G cg02297831 chr4:17616191 MED28 0.46 5.62 0.33 4.91e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs77106637 1.000 rs11605166 chr11:72669777 T/C cg04827223 chr11:72435913 ARAP1 -0.54 -5.71 -0.33 3.08e-8 Type 2 diabetes; CESC cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg00033643 chr7:134001901 SLC35B4 0.42 5.42 0.32 1.36e-7 Mean platelet volume; CESC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg18876405 chr7:65276391 NA 0.49 6.38 0.36 7.93e-10 Aortic root size; CESC cis rs2777491 0.957 rs16971798 chr15:41657144 A/T cg18705301 chr15:41695430 NDUFAF1 0.58 8.67 0.47 4.41e-16 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05522145 chr7:53255065 NA -0.53 -6.45 -0.37 5.41e-10 Gut microbiome composition (summer); CESC cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg19717773 chr7:2847554 GNA12 -0.68 -11.76 -0.59 5.77e-26 Height; CESC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg06108461 chr20:60628389 TAF4 -0.92 -14.34 -0.66 6.58e-35 Body mass index; CESC cis rs7927771 1.000 rs7927771 chr11:47781306 A/G cg20307385 chr11:47447363 PSMC3 -0.51 -6.23 -0.36 1.79e-9 Subjective well-being; CESC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg05872129 chr22:39784769 NA -0.8 -11.24 -0.57 3.28e-24 Intelligence (multi-trait analysis); CESC cis rs35110281 0.805 rs3788062 chr21:44991159 C/T cg21573476 chr21:45109991 RRP1B -0.43 -5.96 -0.34 8.16e-9 Mean corpuscular volume; CESC cis rs3733585 0.699 rs6844316 chr4:9958977 A/G cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11168618 0.567 rs12372687 chr12:48811799 G/T cg24011408 chr12:48396354 COL2A1 0.36 5.68 0.33 3.52e-8 Adiponectin levels; CESC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.69 0.38 1.3100000000000001e-10 Electroencephalogram traits; CESC cis rs10911232 0.507 rs3934697 chr1:183027512 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.49 0.64 6.27e-32 Hypertriglyceridemia; CESC cis rs75804782 0.641 rs1030786 chr2:239361150 A/G cg18131467 chr2:239335373 ASB1 -0.7 -5.88 -0.34 1.26e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs4332037 0.624 rs11764337 chr7:1892309 A/G cg23422044 chr7:1970798 MAD1L1 0.49 5.5 0.32 8.94e-8 Bipolar disorder; CESC cis rs2456568 0.803 rs10831138 chr11:93640468 T/C cg26875233 chr11:93583750 C11orf90 -0.29 -5.06 -0.3 7.7e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs10751667 0.961 rs7396670 chr11:929269 A/G cg01483505 chr11:975446 AP2A2 0.39 5.07 0.3 7.63e-7 Alzheimer's disease (late onset); CESC cis rs6570726 1.000 rs374464 chr6:145846679 A/C cg05347473 chr6:146136440 FBXO30 0.42 5.63 0.33 4.5e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs2832191 0.716 rs2692625 chr21:30446360 C/G cg24692254 chr21:30365293 RNF160 0.99 17.29 0.73 2.32e-45 Dental caries; CESC cis rs870825 0.616 rs9715644 chr4:185632965 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.89 0.39 3.95e-11 Blood protein levels; CESC cis rs7208859 0.673 rs56846352 chr17:29119188 C/T cg13385521 chr17:29058706 SUZ12P 0.59 5.49 0.32 9.51e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.08 0.53 1.99e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs10089 1.000 rs10060390 chr5:127452947 C/T cg19767477 chr5:127420684 SLC12A2 -0.4 -5.32 -0.31 2.18e-7 Ileal carcinoids; CESC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg08470875 chr2:26401718 FAM59B -0.62 -6.71 -0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs13242816 1.000 rs2191499 chr7:116138599 C/T cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC trans rs3741404 0.665 rs12418535 chr11:63910980 A/G cg15268290 chr11:83690587 DLG2 0.43 6.04 0.35 5.23e-9 Platelet count; CESC cis rs78456975 1.000 rs10208340 chr2:1563100 G/A cg01028140 chr2:1542097 TPO -0.5 -5.35 -0.31 1.89e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.76 9.46 0.5 1.71e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6456156 0.792 rs7775443 chr6:167513252 A/C cg07741184 chr6:167504864 NA -0.39 -7.0 -0.39 2.13e-11 Primary biliary cholangitis; CESC cis rs7178572 0.962 rs1022172 chr15:77793359 A/G cg22256960 chr15:77711686 NA -0.58 -7.68 -0.43 3.02e-13 Type 2 diabetes; CESC cis rs11792861 0.926 rs72607169 chr9:111832471 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 5.26 0.31 3.04e-7 Menarche (age at onset); CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg03188948 chr7:1209495 NA 0.61 6.98 0.39 2.32e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13672103 chr12:57985290 PIP4K2C -0.42 -6.07 -0.35 4.36e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05214679 chr19:36630902 CAPNS1 0.54 6.23 0.36 1.82e-9 Gut microbiome composition (summer); CESC cis rs12497850 0.931 rs7623023 chr3:48914238 G/A cg03060546 chr3:49711283 APEH 0.45 5.75 0.33 2.44e-8 Parkinson's disease; CESC cis rs6120849 0.951 rs55670307 chr20:33720494 T/C cg24642439 chr20:33292090 TP53INP2 0.62 6.49 0.37 4.3e-10 Protein C levels; CESC cis rs3106136 0.967 rs11722476 chr4:95170839 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.76 -0.38 8.54e-11 Capecitabine sensitivity; CESC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs6570726 0.935 rs369458 chr6:145812809 A/G cg23711669 chr6:146136114 FBXO30 0.83 12.23 0.6 1.41e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs12900413 0.562 rs2118849 chr15:90302399 G/T cg24249390 chr15:90295951 MESP1 -0.4 -5.37 -0.31 1.75e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs7772486 0.875 rs2180192 chr6:146322284 T/C cg05347473 chr6:146136440 FBXO30 0.52 6.7 0.38 1.25e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg25204440 chr1:209979598 IRF6 0.6 6.23 0.36 1.86e-9 Cleft lip with or without cleft palate; CESC cis rs4654899 0.802 rs7517642 chr1:21252696 T/C cg05370193 chr1:21551575 ECE1 0.38 5.51 0.32 8.58e-8 Superior frontal gyrus grey matter volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13296916 chr12:117348627 FBXW8 0.53 6.98 0.39 2.37e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs36051895 0.623 rs1555476 chr9:5233054 T/C cg02405213 chr9:5042618 JAK2 -0.58 -6.32 -0.36 1.12e-9 Pediatric autoimmune diseases; CESC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg19766460 chr21:43528205 UMODL1;C21orf128 0.59 6.63 0.38 1.82e-10 IgG glycosylation; CESC cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg19539972 chr4:7069911 GRPEL1 0.75 10.0 0.52 3.44e-20 Monocyte percentage of white cells; CESC cis rs1178968 1.000 rs7802062 chr7:72757812 T/C cg25889504 chr7:72793014 NA 0.48 5.08 0.3 7.22e-7 Triglyceride levels; CESC cis rs8114671 0.527 rs6060068 chr20:33415820 T/A cg24642439 chr20:33292090 TP53INP2 0.46 5.45 0.32 1.14e-7 Height; CESC cis rs7216064 0.861 rs62084252 chr17:65879578 G/C cg07042672 chr17:66097459 LOC651250 -0.62 -7.3 -0.41 3.34e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg02426739 chr12:132285352 NA 0.37 5.27 0.31 2.86e-7 Migraine; CESC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.61 0.38 2.05e-10 Prudent dietary pattern; CESC cis rs6460942 1.000 rs77010200 chr7:12290724 G/A cg20607287 chr7:12443886 VWDE -0.74 -7.82 -0.43 1.24e-13 Coronary artery disease; CESC cis rs684232 0.602 rs401592 chr17:551316 T/C cg15660573 chr17:549704 VPS53 -0.8 -11.67 -0.58 1.16e-25 Prostate cancer; CESC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg16405210 chr4:1374714 KIAA1530 -0.44 -5.87 -0.34 1.33e-8 Obesity-related traits; CESC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg19622623 chr12:86230825 RASSF9 -0.46 -5.93 -0.34 9.45e-9 Major depressive disorder; CESC cis rs9291683 0.551 rs62295971 chr4:9978142 G/A cg11266682 chr4:10021025 SLC2A9 0.61 12.55 0.61 1.12e-28 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14288281 chr1:1093457 NA 0.55 6.18 0.35 2.45e-9 Gut microbiome composition (summer); CESC cis rs854765 0.547 rs4072739 chr17:17884660 G/A cg04398451 chr17:18023971 MYO15A -0.6 -8.63 -0.47 5.68e-16 Total body bone mineral density; CESC cis rs870825 0.616 rs6844588 chr4:185644517 T/G cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs1879734 0.731 rs11206195 chr1:54164156 T/C cg23596471 chr1:54105337 GLIS1 0.33 5.45 0.32 1.17e-7 Mitral valve prolapse; CESC cis rs2952156 0.959 rs1495101 chr17:37832103 C/A cg20243544 chr17:37824526 PNMT 0.6 7.38 0.41 2.01e-12 Asthma; CESC cis rs4704187 0.687 rs13360638 chr5:74433258 G/A cg03227963 chr5:74354835 NA 0.3 5.46 0.32 1.07e-7 Response to amphetamines; CESC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.69 0.38 1.33e-10 Bipolar disorder; CESC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg24209194 chr3:40518798 ZNF619 0.5 6.3 0.36 1.21e-9 Renal cell carcinoma; CESC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg10800226 chr5:1850261 NA 0.33 5.34 0.31 2.04e-7 Cardiovascular disease risk factors; CESC cis rs6580649 0.941 rs4589362 chr12:48478664 T/C cg05342945 chr12:48394962 COL2A1 0.5 5.74 0.33 2.59e-8 Lung cancer; CESC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg19257562 chr1:2043853 PRKCZ 0.41 6.72 0.38 1.08e-10 Height; CESC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg16325326 chr1:53192061 ZYG11B 0.95 16.94 0.72 4.11e-44 Monocyte count; CESC cis rs3540 0.512 rs17263706 chr15:91078803 G/T cg22089800 chr15:90895588 ZNF774 0.61 7.91 0.44 6.88e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs977987 0.806 rs4146809 chr16:75415775 A/G cg03315344 chr16:75512273 CHST6 -0.4 -5.83 -0.34 1.56e-8 Dupuytren's disease; CESC cis rs10791097 0.694 rs4456262 chr11:130755813 C/T cg12179176 chr11:130786555 SNX19 -0.69 -9.76 -0.51 1.95e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs12142240 0.698 rs17357683 chr1:46815378 C/T cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.35 -0.31 1.92e-7 Total body bone mineral density; CESC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg25072359 chr17:41440525 NA -0.49 -7.39 -0.41 1.92e-12 Menopause (age at onset); CESC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.74 -9.92 -0.52 6.35e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7814319 0.966 rs10955069 chr8:97253788 C/T cg20787634 chr8:97240163 UQCRB -0.6 -7.96 -0.44 5.1e-14 Lung function (FVC); CESC cis rs763121 0.962 rs2071887 chr22:38879010 A/T cg14440974 chr22:39074834 NA -0.39 -5.42 -0.32 1.37e-7 Menopause (age at onset); CESC trans rs4950322 0.570 rs72691012 chr1:146711400 G/C cg04954894 chr8:38089920 DDHD2 -0.6 -6.38 -0.36 7.74e-10 Protein quantitative trait loci; CESC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg13628971 chr7:2884303 GNA12 0.65 8.32 0.45 4.79e-15 Height; CESC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs13272623 0.502 rs268601 chr8:71518548 C/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.44 -5.55 -0.32 7.08e-8 IgG glycosylation; CESC cis rs2286503 0.752 rs59538378 chr7:22877097 G/A cg13679077 chr7:22862647 TOMM7 0.58 7.49 0.42 1.05e-12 Fibrinogen; CESC trans rs11252926 0.527 rs10904093 chr10:436848 A/G cg00953403 chr17:74099816 EXOC7 -0.56 -7.2 -0.4 6.38e-12 Psychosis in Alzheimer's disease; CESC cis rs2074585 0.806 rs8033813 chr15:90999715 A/T cg10434728 chr15:90938212 IQGAP1 0.41 7.32 0.41 3.03e-12 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs71403859 0.803 rs7203606 chr16:71590511 A/C cg08717414 chr16:71523259 ZNF19 -0.79 -7.11 -0.4 1.09e-11 Post bronchodilator FEV1; CESC trans rs561341 1.000 rs542132 chr17:30307193 A/T cg27661571 chr11:113659931 NA -0.83 -7.76 -0.43 1.9e-13 Hip circumference adjusted for BMI; CESC cis rs12190007 0.514 rs2984462 chr6:169843903 A/T cg15038512 chr6:170123185 PHF10 -0.52 -7.37 -0.41 2.16e-12 Obesity-related traits; CESC cis rs2635047 0.905 rs7504798 chr18:44610879 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 6.54 0.37 3.21e-10 Educational attainment; CESC cis rs6582630 0.555 rs34145279 chr12:38405588 T/C cg13010199 chr12:38710504 ALG10B 0.54 6.87 0.39 4.7e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs1808579 0.904 rs1652344 chr18:21128857 T/C cg14672496 chr18:21087552 C18orf8 0.43 6.05 0.35 4.82e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs950027 0.620 rs1153855 chr15:45660758 C/G cg21132104 chr15:45694354 SPATA5L1 0.67 8.55 0.46 1.01e-15 Response to fenofibrate (adiponectin levels); CESC cis rs9303542 0.559 rs12946931 chr17:46614080 T/C cg04904318 chr17:46607828 HOXB1 -0.6 -5.74 -0.33 2.54e-8 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg13114125 chr14:105738426 BRF1 -0.83 -10.25 -0.53 5.5e-21 Mean platelet volume;Platelet distribution width; CESC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg13126279 chr21:47581558 C21orf56 -0.49 -6.68 -0.38 1.43e-10 Testicular germ cell tumor; CESC cis rs6662572 0.737 rs56316933 chr1:46266725 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.04 0.3 8.63e-7 Blood protein levels; CESC trans rs7937682 0.924 rs6589244 chr11:111534333 T/C cg18187862 chr3:45730750 SACM1L 0.48 6.0 0.35 6.32e-9 Primary sclerosing cholangitis; CESC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg06219351 chr7:158114137 PTPRN2 -0.49 -7.5 -0.42 9.58e-13 Calcium levels; CESC cis rs6142102 0.625 rs6142056 chr20:32541155 T/C cg08999081 chr20:33150536 PIGU 0.34 5.12 0.3 5.84e-7 Skin pigmentation; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg20662616 chr2:30454643 LBH 0.46 6.24 0.36 1.73e-9 Obesity-related traits; CESC cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg02034447 chr16:89574710 SPG7 0.41 5.18 0.3 4.4e-7 Multiple myeloma (IgH translocation); CESC cis rs1062177 1.000 rs2915887 chr5:151205504 C/T cg00977110 chr5:151150581 G3BP1 0.63 6.62 0.38 2.01e-10 Preschool internalizing problems; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23260255 chr3:187871479 LPP 0.48 6.11 0.35 3.47e-9 Gut microbiota (bacterial taxa); CESC cis rs9287719 0.967 rs6761678 chr2:10746341 T/C cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.86 0.34 1.41e-8 Bipolar disorder; CESC cis rs6575793 0.553 rs7154024 chr14:101031710 G/T cg18516195 chr14:101012996 BEGAIN 0.43 5.28 0.31 2.63e-7 Menarche (age at onset); CESC cis rs11245387 0.564 rs7915429 chr10:126510089 T/C cg08799069 chr10:126477246 METTL10 -0.55 -6.52 -0.37 3.64e-10 Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1); CESC cis rs2816062 0.813 rs2816044 chr1:18892826 A/G cg18795169 chr1:18902165 NA -0.91 -17.5 -0.73 4.31e-46 Urate levels in lean individuals; CESC cis rs9389248 0.690 rs6939543 chr6:135255143 A/G cg24558204 chr6:135376177 HBS1L -0.63 -8.71 -0.47 3.23e-16 High light scatter reticulocyte percentage of red cells; CESC cis rs16910800 0.689 rs7101737 chr11:23165031 C/T cg20040320 chr11:23191996 NA -0.65 -6.17 -0.35 2.51e-9 Cancer; CESC cis rs854765 0.663 rs12941550 chr17:17753828 C/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.47 -6.57 -0.37 2.67e-10 Total body bone mineral density; CESC cis rs274567 0.599 rs11242110 chr5:131743777 A/C cg24060327 chr5:131705240 SLC22A5 0.5 6.42 0.37 6.12e-10 Blood metabolite levels; CESC cis rs7246865 0.954 rs1060367 chr19:17215202 G/A cg19418318 chr19:17219073 MYO9B 0.36 6.03 0.35 5.63e-9 Reticulocyte fraction of red cells; CESC cis rs11190604 1.000 rs7079136 chr10:102292709 T/C cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs523522 0.962 rs2168319 chr12:120933217 C/T cg27279351 chr12:120934652 DYNLL1 0.68 8.7 0.47 3.6e-16 High light scatter reticulocyte count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26106524 chr19:19517029 GATAD2A 0.47 6.36 0.36 9.03e-10 Gut microbiota (bacterial taxa); CESC trans rs35110281 0.659 rs11702544 chr21:45091861 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.45 6.05 0.35 4.83e-9 Mean corpuscular volume; CESC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg18876405 chr7:65276391 NA 0.51 5.89 0.34 1.18e-8 Aortic root size; CESC cis rs4566357 0.595 rs10206912 chr2:227921095 A/T cg11843606 chr2:227700838 RHBDD1 -0.52 -7.3 -0.41 3.33e-12 Coronary artery disease; CESC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg19318889 chr4:1322082 MAEA 0.59 7.02 0.4 1.91e-11 Longevity; CESC cis rs8063160 0.799 rs1805007 chr16:89986117 A/G cg07984980 chr16:89898383 SPIRE2 -0.9 -6.11 -0.35 3.45e-9 Red vs non-red hair color;Light vs. dark hair color;Brown vs. non-brown hair color; CESC cis rs796364 0.951 rs281769 chr2:200809709 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.83 8.38 0.46 3.17e-15 Schizophrenia; CESC cis rs2228479 0.541 rs13335395 chr16:89952843 T/A cg00800038 chr16:89945340 TCF25 -0.62 -6.76 -0.38 8.88e-11 Skin colour saturation; CESC cis rs4423214 0.840 rs1629220 chr11:71174553 C/T cg05163923 chr11:71159392 DHCR7 -0.65 -7.55 -0.42 6.91e-13 Vitamin D levels; CESC cis rs9287719 0.967 rs6432120 chr2:10753771 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg27266027 chr21:40555129 PSMG1 0.46 5.58 0.32 6.08e-8 Cognitive function; CESC cis rs734999 0.588 rs3748818 chr1:2525660 G/A cg18854424 chr1:2615690 NA 0.27 5.06 0.3 7.78e-7 Ulcerative colitis; CESC cis rs806215 0.901 rs989100 chr7:127220918 T/C cg25922125 chr7:127225783 GCC1 -0.5 -5.69 -0.33 3.31e-8 Type 2 diabetes; CESC cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg21214613 chr1:16344536 HSPB7 0.37 5.34 0.31 2.03e-7 Dilated cardiomyopathy; CESC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6456156 0.819 rs9457273 chr6:167520749 A/T cg07741184 chr6:167504864 NA -0.39 -7.0 -0.39 2.13e-11 Primary biliary cholangitis; CESC trans rs3942852 0.910 rs10742829 chr11:48115837 C/T cg15704280 chr7:45808275 SEPT13 0.63 7.08 0.4 1.31e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg22875332 chr1:76189707 ACADM 0.69 9.21 0.49 1.01e-17 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7188697 0.922 rs37041 chr16:58579886 T/C cg02549819 chr16:58548995 SETD6 -0.43 -5.35 -0.31 1.9e-7 QT interval; CESC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg19077165 chr18:44547161 KATNAL2 -0.54 -7.94 -0.44 5.81e-14 Personality dimensions; CESC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg10494973 chr17:80897199 TBCD 0.53 6.93 0.39 3.11e-11 Breast cancer; CESC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.68 0.33 3.6e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2594989 1.000 rs2606752 chr3:11360170 A/G cg00170343 chr3:11313890 ATG7 0.59 5.18 0.3 4.42e-7 Circulating chemerin levels; CESC cis rs826838 1.000 rs826851 chr12:39112639 A/G cg13010199 chr12:38710504 ALG10B -0.48 -6.58 -0.37 2.53e-10 Heart rate; CESC cis rs1707322 0.686 rs2275085 chr1:46085852 C/T cg06784218 chr1:46089804 CCDC17 -0.42 -7.26 -0.41 4.44e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2797685 0.898 rs3753503 chr1:7841971 G/A cg04725166 chr1:7887271 PER3 -0.45 -6.09 -0.35 4e-9 Crohn's disease; CESC cis rs992157 0.697 rs13384682 chr2:219069137 G/A cg00012203 chr2:219082015 ARPC2 0.86 12.41 0.61 3.6e-28 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17436946 chr4:39699568 UBE2K 0.57 6.42 0.37 6.44e-10 Gut microbiome composition (summer); CESC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg08859206 chr1:53392774 SCP2 0.55 7.28 0.41 3.86e-12 Monocyte count; CESC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg08470875 chr2:26401718 FAM59B 0.75 7.79 0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs12476592 0.571 rs4671512 chr2:63753095 A/G cg17519650 chr2:63277830 OTX1 -0.47 -5.36 -0.31 1.83e-7 Childhood ear infection; CESC cis rs1348850 0.598 rs1405717 chr2:178500101 G/T cg23306229 chr2:178417860 TTC30B 0.6 7.53 0.42 7.93e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2710642 0.962 rs2058567 chr2:63091426 T/C cg17519650 chr2:63277830 OTX1 0.49 6.18 0.36 2.36e-9 LDL cholesterol levels;LDL cholesterol; CESC cis rs7666738 0.830 rs921521 chr4:98838339 A/G cg05340658 chr4:99064831 C4orf37 0.71 10.13 0.53 1.34e-20 Colonoscopy-negative controls vs population controls; CESC cis rs7124681 0.528 rs74608150 chr11:47696214 A/T cg18512352 chr11:47633146 NA 0.34 5.25 0.31 3.15e-7 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs6032067 0.777 rs116517830 chr20:43784872 G/A cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.89e-7 Blood protein levels; CESC cis rs7020830 0.931 rs13297576 chr9:37142189 A/C cg14294708 chr9:37120828 ZCCHC7 1.25 25.19 0.84 2.66e-72 Schizophrenia; CESC cis rs7264396 0.790 rs2425096 chr20:34308588 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.52 -0.58 3.56e-25 Total cholesterol levels; CESC cis rs12048904 0.595 rs10493937 chr1:101342650 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.65 -9.39 -0.5 2.83e-18 Multiple sclerosis; CESC cis rs34172651 0.917 rs2343606 chr16:24793741 C/T cg06028605 chr16:24865363 SLC5A11 0.41 6.22 0.36 1.94e-9 Intelligence (multi-trait analysis); CESC cis rs6963495 0.818 rs73190149 chr7:105152793 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.5 -0.32 9.08e-8 Bipolar disorder (body mass index interaction); CESC cis rs8077577 1.000 rs62073606 chr17:18069142 G/A cg16794390 chr17:18148240 FLII 0.47 6.04 0.35 5.22e-9 Obesity-related traits; CESC trans rs3780486 0.813 rs3780488 chr9:33133812 T/C cg20290983 chr6:43655470 MRPS18A 0.99 17.78 0.74 4.34e-47 IgG glycosylation; CESC cis rs2439831 0.681 rs956391 chr15:43617493 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.88 -9.72 -0.51 2.77e-19 Lung cancer in ever smokers; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03648789 chr2:38304037 CYP1B1 -0.49 -6.43 -0.37 5.82e-10 Ulcerative colitis; CESC cis rs10752881 0.935 rs10797834 chr1:183048749 T/G ch.1.3577855R chr1:183094577 LAMC1 0.86 13.61 0.64 2.32e-32 Colorectal cancer; CESC cis rs1983170 1.000 rs483532 chr1:91980447 A/G cg02896835 chr1:92012615 NA -0.53 -6.1 -0.35 3.8e-9 Eosinophil percentage of white cells; CESC cis rs929596 0.785 rs17862875 chr2:234649302 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.68 -8.31 -0.45 5.09e-15 Total bilirubin levels in HIV-1 infection; CESC trans rs1814175 0.817 rs10839351 chr11:49758153 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.89 -0.77 1.79e-54 Height; CESC cis rs2011503 1.000 rs4808962 chr19:19579557 A/G cg11584989 chr19:19387371 SF4 0.62 7.22 0.41 5.54e-12 Bipolar disorder; CESC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.61e-7 Life satisfaction; CESC cis rs7098414 0.511 rs4934134 chr10:82160582 C/T cg00277334 chr10:82204260 NA -0.52 -7.68 -0.43 3.1400000000000003e-13 Post bronchodilator FEV1; CESC cis rs796364 0.760 rs2881594 chr2:201026183 T/A cg23649088 chr2:200775458 C2orf69 -0.6 -5.16 -0.3 4.78e-7 Schizophrenia; CESC cis rs2985684 0.894 rs7152110 chr14:50018218 T/C cg02151108 chr14:50098012 C14orf104 -0.39 -5.09 -0.3 6.78e-7 Carotid intima media thickness; CESC cis rs4595586 0.525 rs17467376 chr12:39377551 T/G cg13010199 chr12:38710504 ALG10B 0.44 5.51 0.32 8.37e-8 Morning vs. evening chronotype; CESC cis rs11577318 0.853 rs11803933 chr1:26629465 G/C cg00852783 chr1:26633632 UBXN11 0.5 6.99 0.39 2.17e-11 Granulocyte percentage of myeloid white cells; CESC cis rs262150 1.000 rs262150 chr7:158777934 G/A cg19418458 chr7:158789849 NA -0.48 -7.58 -0.42 5.94e-13 Facial morphology (factor 20); CESC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 12.23 0.6 1.42e-27 Alzheimer's disease; CESC cis rs477692 0.905 rs7905466 chr10:131438937 A/T cg05714579 chr10:131428358 MGMT -0.57 -8.14 -0.45 1.57e-14 Response to temozolomide; CESC cis rs1707322 0.691 rs61784799 chr1:46177748 A/G cg05343316 chr1:45956843 TESK2 -0.51 -6.32 -0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7552167 0.925 rs11249020 chr1:24512804 A/G cg01960748 chr1:24522592 NA -0.42 -5.34 -0.31 2.01e-7 Psoriasis vulgaris; CESC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs3015497 0.753 rs4643225 chr14:51122205 G/C cg09863266 chr14:51125203 SAV1 -0.35 -5.4 -0.31 1.51e-7 Mean platelet volume; CESC cis rs4423214 1.000 rs12422045 chr11:71154820 C/T cg24826892 chr11:71159390 DHCR7 0.45 5.32 0.31 2.25e-7 Vitamin D levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00185004 chr17:55752472 MSI2 -0.59 -6.9 -0.39 3.8e-11 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg12311346 chr5:56204834 C5orf35 -0.71 -8.58 -0.47 8.07e-16 Initial pursuit acceleration; CESC cis rs11122272 0.735 rs1076804 chr1:231498460 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.65 -0.43 3.62e-13 Hemoglobin concentration; CESC cis rs1153858 1.000 rs4775937 chr15:45678614 C/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs559928 0.556 rs734762 chr11:63912189 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 6.06 0.35 4.55e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg03806693 chr22:41940476 POLR3H -1.13 -13.58 -0.64 3.04e-32 Vitiligo; CESC trans rs3942852 0.868 rs58407618 chr11:48104167 T/G cg15704280 chr7:45808275 SEPT13 -0.61 -6.84 -0.39 5.37e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs35110281 0.743 rs230640 chr21:44914815 A/T cg01579765 chr21:45077557 HSF2BP 0.51 8.7 0.47 3.61e-16 Mean corpuscular volume; CESC cis rs9308731 0.623 rs6708784 chr2:111927379 A/G cg04202892 chr2:111875749 ACOXL 0.42 5.93 0.34 9.43e-9 Chronic lymphocytic leukemia; CESC cis rs10924309 0.889 rs10802247 chr1:245858508 G/A cg00036263 chr1:245852353 KIF26B -0.41 -5.18 -0.3 4.4e-7 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs11764590 0.756 rs17132130 chr7:2108036 G/C cg21782813 chr7:2030301 MAD1L1 -0.4 -5.07 -0.3 7.46e-7 Neuroticism; CESC cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg25554036 chr4:6271136 WFS1 0.52 8.51 0.46 1.34e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2549003 0.966 rs10072571 chr5:131816711 A/C cg21138405 chr5:131827807 IRF1 0.54 9.24 0.49 8.12e-18 Asthma (sex interaction); CESC cis rs8028182 0.636 rs7171507 chr15:75737287 T/C cg20655648 chr15:75932815 IMP3 0.49 6.04 0.35 5.28e-9 Sudden cardiac arrest; CESC cis rs3857067 0.806 rs10008044 chr4:95092850 A/G cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.04 -0.49 3.47e-17 QT interval; CESC trans rs877282 0.853 rs7079450 chr10:755932 T/A cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs593982 0.925 rs603509 chr11:65507605 C/T cg08755490 chr11:65554678 OVOL1 -1.27 -19.88 -0.77 1.83e-54 Atopic dermatitis; CESC cis rs9302635 0.513 rs8044555 chr16:72152755 T/C cg16558253 chr16:72132732 DHX38 -0.46 -6.04 -0.35 5.19e-9 Blood protein levels; CESC cis rs6121246 0.909 rs6060633 chr20:30263317 G/T cg13852791 chr20:30311386 BCL2L1 0.77 8.18 0.45 1.17e-14 Mean corpuscular hemoglobin; CESC cis rs4253772 0.530 rs9627387 chr22:46684678 A/G cg18190219 chr22:46762943 CELSR1 -0.46 -6.01 -0.35 6.25e-9 LDL cholesterol;Cholesterol, total; CESC cis rs796364 0.760 rs74993507 chr2:201068684 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.82 -6.63 -0.38 1.86e-10 Schizophrenia; CESC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg10691866 chr7:65817282 TPST1 0.33 5.55 0.32 6.96e-8 Aortic root size; CESC cis rs7940866 0.646 rs10894293 chr11:130824213 C/T cg12179176 chr11:130786555 SNX19 -0.61 -8.46 -0.46 1.87e-15 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00593699 chr11:472782 PTDSS2 0.51 7.16 0.4 7.99e-12 Fibrinogen levels; CESC cis rs9309473 1.000 rs6724782 chr2:73679990 T/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.17 -0.35 2.53e-9 Metabolite levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19273467 chr1:32110819 PEF1 0.48 6.21 0.36 2.03e-9 Systemic lupus erythematosus; CESC cis rs3806843 0.900 rs2337984 chr5:140136811 G/A cg16179182 chr5:140090404 VTRNA1-1 0.42 5.43 0.32 1.3e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6570726 0.935 rs397418 chr6:145842362 C/T cg23711669 chr6:146136114 FBXO30 0.79 11.78 0.59 4.77e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -5.72 -0.33 2.85e-8 Extrinsic epigenetic age acceleration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18179305 chr5:89705894 CETN3 -0.48 -6.79 -0.38 7.33e-11 Gut microbiota (bacterial taxa); CESC cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg04317338 chr11:64019027 PLCB3 0.7 5.96 0.34 8.22e-9 Mean platelet volume; CESC cis rs17376456 0.877 rs9314101 chr5:93461593 A/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.44 0.32 1.23e-7 Diabetic retinopathy; CESC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg04944784 chr2:26401820 FAM59B -0.79 -8.87 -0.48 1.09e-16 Gut microbiome composition (summer); CESC cis rs12618769 0.652 rs3754872 chr2:99223925 A/T cg10123293 chr2:99228465 UNC50 0.41 5.35 0.31 1.88e-7 Bipolar disorder; CESC cis rs2295499 0.678 rs12503560 chr4:2714482 T/C cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.28 -0.31 2.66e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs11098499 0.738 rs34566984 chr4:120361270 G/A cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs1707322 1.000 rs7539800 chr1:46262129 C/G cg03146154 chr1:46216737 IPP -0.78 -10.71 -0.55 1.78e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg22903471 chr2:27725779 GCKR -0.5 -7.08 -0.4 1.32e-11 Menopause (age at onset); CESC cis rs17854409 0.881 rs1046784 chr20:61472808 G/C cg07645718 chr20:61493192 TCFL5 0.81 5.37 0.31 1.69e-7 Obesity-related traits; CESC cis rs2486288 0.656 rs11637920 chr15:45550905 T/C cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg04317338 chr11:64019027 PLCB3 0.89 9.26 0.49 6.99e-18 Mean platelet volume; CESC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg11764359 chr7:65958608 NA -0.8 -12.02 -0.59 7.52e-27 Aortic root size; CESC cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg19748678 chr4:122722346 EXOSC9 0.8 10.1 0.53 1.66e-20 Type 2 diabetes; CESC cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg06481639 chr22:41940642 POLR3H 0.59 6.25 0.36 1.61e-9 Vitiligo; CESC cis rs2290159 0.800 rs9809947 chr3:12655944 T/C cg23032965 chr3:12705835 RAF1 0.55 6.04 0.35 5.13e-9 Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23084309 chr19:6280164 MLLT1 0.55 6.28 0.36 1.35e-9 Gut microbiome composition (summer); CESC cis rs7247513 0.930 rs34321000 chr19:12713088 C/T cg01871581 chr19:12707946 ZNF490 -0.89 -15.12 -0.68 1.12e-37 Bipolar disorder; CESC trans rs66573146 0.572 rs66819208 chr4:6946128 A/G cg07817883 chr1:32538562 TMEM39B 1.25 8.66 0.47 4.59e-16 Granulocyte percentage of myeloid white cells; CESC cis rs425277 0.606 rs3128295 chr1:2068480 C/T cg23803603 chr1:2058230 PRKCZ -0.31 -5.24 -0.31 3.2e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19612890 chr12:131356591 RAN 0.54 6.0 0.35 6.36e-9 Gut microbiome composition (summer); CESC cis rs7605827 0.836 rs9287659 chr2:15595755 C/T cg19274914 chr2:15703543 NA 0.33 5.97 0.34 7.72e-9 Educational attainment (years of education); CESC cis rs9911578 0.967 rs12603238 chr17:57130785 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -5.19 -0.3 4.23e-7 Intelligence (multi-trait analysis); CESC cis rs959260 0.623 rs7207618 chr17:73321687 T/C cg20590849 chr17:73267439 MIF4GD -0.44 -5.38 -0.31 1.63e-7 Systemic lupus erythematosus; CESC cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg26116260 chr4:7069785 GRPEL1 -0.87 -9.28 -0.5 6.45e-18 Monocyte percentage of white cells; CESC cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg00677455 chr12:58241039 CTDSP2 0.52 6.62 0.38 2.03e-10 Multiple sclerosis; CESC cis rs561341 0.943 rs508566 chr17:30289861 G/C cg00745463 chr17:30367425 LRRC37B -0.81 -7.19 -0.4 6.78e-12 Hip circumference adjusted for BMI; CESC cis rs8114671 0.562 rs2889861 chr20:33405664 C/T cg06115741 chr20:33292138 TP53INP2 0.44 5.41 0.32 1.41e-7 Height; CESC cis rs16858210 0.874 rs34113436 chr3:183573836 G/A cg03417191 chr3:183542750 MAP6D1 -0.4 -5.11 -0.3 6.11e-7 Menopause (age at onset); CESC cis rs2070433 0.539 rs2839314 chr21:47961067 A/G cg12379764 chr21:47803548 PCNT 0.62 8.21 0.45 9.85e-15 Lymphocyte counts; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00459447 chr7:108210006 THAP5;DNAJB9 -0.45 -6.07 -0.35 4.3e-9 Ulcerative colitis; CESC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg16680214 chr1:154839983 KCNN3 -0.48 -7.31 -0.41 3.09e-12 Prostate cancer; CESC trans rs12681287 0.517 rs34596274 chr8:87517679 C/T cg27317242 chr8:23145699 R3HCC1 -0.52 -6.13 -0.35 3.12e-9 Caudate activity during reward; CESC cis rs832540 0.519 rs10940518 chr5:56270794 C/T cg12311346 chr5:56204834 C5orf35 -0.45 -5.62 -0.33 4.74e-8 Coronary artery disease; CESC cis rs7216064 0.773 rs74541577 chr17:65853651 C/T cg07042672 chr17:66097459 LOC651250 -0.54 -5.62 -0.33 4.77e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11676348 0.729 rs13013361 chr2:218947515 A/T cg00012203 chr2:219082015 ARPC2 -0.5 -6.37 -0.36 8.46e-10 Ulcerative colitis; CESC trans rs1814175 0.647 rs4881649 chr11:49845560 A/G cg15704280 chr7:45808275 SEPT13 -0.81 -11.37 -0.57 1.15e-24 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12232852 chr3:69129018 UBA3 0.51 6.69 0.38 1.34e-10 Gut microbiota (bacterial taxa); CESC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg12463550 chr7:65579703 CRCP 0.57 7.19 0.4 6.54e-12 Aortic root size; CESC trans rs4650994 0.507 rs12141152 chr1:178514165 C/T cg05059571 chr16:84539110 KIAA1609 -0.4 -6.22 -0.36 1.93e-9 HDL cholesterol levels;HDL cholesterol; CESC cis rs3733585 0.579 rs4235353 chr4:10122934 C/T cg02734326 chr4:10020555 SLC2A9 -0.37 -5.03 -0.3 8.89e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4594175 0.926 rs116372620 chr14:51599682 T/C cg23942311 chr14:51606299 NA 0.4 6.02 0.35 5.87e-9 Cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26542412 chr1:92350568 TGFBR3 -0.62 -7.59 -0.42 5.31e-13 Gut microbiome composition (summer); CESC cis rs344364 0.511 rs911391 chr16:1947016 C/A cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs7247513 1.000 rs8104385 chr19:12700284 G/A cg01871581 chr19:12707946 ZNF490 -0.88 -15.42 -0.69 9.87e-39 Bipolar disorder; CESC cis rs72781680 0.611 rs7596820 chr2:24335036 G/C cg06627628 chr2:24431161 ITSN2 -0.67 -6.51 -0.37 3.7e-10 Lymphocyte counts; CESC cis rs2932538 0.922 rs112363416 chr1:113107543 T/C cg22162597 chr1:113214053 CAPZA1 0.6 7.33 0.41 2.75e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg01579765 chr21:45077557 HSF2BP 0.52 9.13 0.49 1.86e-17 Mean corpuscular volume; CESC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg26314531 chr2:26401878 FAM59B 0.57 6.58 0.37 2.5e-10 Gut microbiome composition (summer); CESC cis rs6831352 0.760 rs1311616 chr4:100012303 T/G cg12011299 chr4:100065546 ADH4 0.61 6.71 0.38 1.17e-10 Alcohol dependence; CESC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC cis rs11690935 0.959 rs11897196 chr2:172585595 G/A cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.97 -0.68 4e-37 Schizophrenia; CESC cis rs3008870 0.959 rs4655658 chr1:67389608 C/T cg02640540 chr1:67518911 SLC35D1 0.47 5.05 0.3 8.1e-7 Lymphocyte percentage of white cells; CESC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg10560079 chr2:191398806 TMEM194B 0.47 6.77 0.38 8.47e-11 Pulse pressure; CESC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg26939375 chr7:64535504 NA 0.76 10.88 0.56 5.07e-23 Calcium levels; CESC trans rs7944735 0.786 rs7123436 chr11:48013484 G/A cg15704280 chr7:45808275 SEPT13 0.64 6.51 0.37 3.79e-10 Intraocular pressure; CESC cis rs2637266 0.678 rs2583060 chr10:78558893 C/T cg18941641 chr10:78392320 NA 0.4 7.57 0.42 6.04e-13 Pulmonary function; CESC cis rs55788414 1.000 rs67345347 chr16:81185125 G/C cg06400318 chr16:81190750 PKD1L2 -0.61 -6.81 -0.39 6.38e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg04450456 chr4:17643702 FAM184B 0.4 5.69 0.33 3.35e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7412746 0.658 rs12405726 chr1:150956128 G/A cg04414720 chr1:150670196 GOLPH3L 0.51 6.64 0.38 1.79e-10 Melanoma; CESC cis rs12476592 0.602 rs10865338 chr2:63732509 A/G cg17519650 chr2:63277830 OTX1 -0.47 -5.4 -0.31 1.46e-7 Childhood ear infection; CESC cis rs7772486 0.875 rs1929523 chr6:146339989 T/A cg05347473 chr6:146136440 FBXO30 0.52 6.71 0.38 1.17e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4253772 0.513 rs6008700 chr22:46722560 C/T cg09491104 chr22:46646882 C22orf40 -0.55 -7.99 -0.44 4.14e-14 LDL cholesterol;Cholesterol, total; CESC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg25072359 chr17:41440525 NA -0.49 -7.21 -0.41 5.7e-12 Menopause (age at onset); CESC cis rs1371867 0.875 rs1788168 chr8:101324960 G/T cg11906718 chr8:101322791 RNF19A 0.46 5.92 0.34 1.02e-8 Atrioventricular conduction; CESC cis rs11864453 0.560 rs6499561 chr16:72148404 A/G cg16558253 chr16:72132732 DHX38 -0.54 -8.58 -0.47 8.07e-16 Fibrinogen levels; CESC cis rs6460942 0.597 rs12699388 chr7:12536336 T/C cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06131143 chr2:48757612 NA -0.42 -6.05 -0.35 4.82e-9 Asthma; CESC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg19163074 chr7:65112434 INTS4L2 -0.43 -5.34 -0.31 2e-7 Aortic root size; CESC trans rs9858542 1.000 rs9823546 chr3:49705512 T/A cg21659725 chr3:3221576 CRBN -0.53 -6.6 -0.38 2.27e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs10743315 0.557 rs77194694 chr12:19354075 A/G cg02471346 chr12:19282374 PLEKHA5 0.7 5.25 0.31 3.2e-7 Gut microbiota (bacterial taxa); CESC cis rs1865721 1.000 rs62089511 chr18:73197629 C/T cg26385618 chr18:73139727 C18orf62 -0.51 -7.54 -0.42 7.49e-13 Intelligence; CESC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -10.3 -0.53 3.72e-21 Extrinsic epigenetic age acceleration; CESC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg08704250 chr15:31115839 NA -0.61 -7.86 -0.43 9.71e-14 Huntington's disease progression; CESC cis rs62432291 0.681 rs420054 chr6:159655084 C/G cg14500486 chr6:159655392 FNDC1 -0.6 -5.92 -0.34 9.83e-9 Joint mobility (Beighton score); CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg16329901 chr2:220094343 ATG9A;ANKZF1 -0.52 -6.34 -0.36 1e-9 Gut microbiota (bacterial taxa); CESC cis rs1348850 1.000 rs1348850 chr2:178418575 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.7 9.45 0.5 1.89e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1023500 0.573 rs133370 chr22:42465260 T/C cg04733989 chr22:42467013 NAGA 0.79 12.05 0.59 5.98e-27 Schizophrenia; CESC trans rs208520 0.802 rs4710315 chr6:66887594 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.49 -0.58 4.62e-25 Exhaled nitric oxide output; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13709765 chr18:3451484 TGIF1 -0.46 -6.21 -0.36 2.02e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg11890956 chr21:40555474 PSMG1 -0.66 -9.44 -0.5 1.99e-18 Menarche (age at onset); CESC cis rs763121 0.853 rs35522482 chr22:39063015 C/A cg14440974 chr22:39074834 NA -0.42 -5.82 -0.34 1.69e-8 Menopause (age at onset); CESC cis rs6912958 0.781 rs7761814 chr6:88188309 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -5.82 -0.34 1.68e-8 Monocyte percentage of white cells; CESC cis rs4950322 0.748 rs17356680 chr1:146826644 C/T cg22381352 chr1:146742008 CHD1L -0.47 -5.04 -0.3 8.64e-7 Protein quantitative trait loci; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11066750 chr2:120125096 C2orf76;DBI 0.58 6.73 0.38 1.07e-10 Gut microbiome composition (summer); CESC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg03351412 chr1:154909251 PMVK 0.65 8.71 0.47 3.36e-16 Prostate cancer; CESC cis rs7615952 0.932 rs13065725 chr3:125632289 C/A cg05084668 chr3:125655381 ALG1L -0.49 -5.61 -0.33 5.14e-8 Blood pressure (smoking interaction); CESC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg24642844 chr7:1081250 C7orf50 -0.62 -8.1 -0.45 1.97e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2274273 0.638 rs17672364 chr14:55705904 G/T cg04306507 chr14:55594613 LGALS3 0.31 5.15 0.3 5.01e-7 Protein biomarker; CESC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.51e-24 Menopause (age at onset); CESC cis rs7582720 1.000 rs72934738 chr2:203740861 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs28830936 0.966 rs17678552 chr15:42066190 T/C cg17847044 chr15:42102381 MAPKBP1 -0.34 -5.08 -0.3 7.07e-7 Diastolic blood pressure; CESC cis rs4835473 0.897 rs35162238 chr4:144614671 A/G cg25736465 chr4:144833511 NA -0.36 -5.45 -0.32 1.17e-7 Immature fraction of reticulocytes; CESC cis rs6545883 0.831 rs9309336 chr2:61763165 T/C cg15711740 chr2:61764176 XPO1 -0.44 -5.34 -0.31 1.95e-7 Tuberculosis; CESC cis rs2717559 0.542 rs34147336 chr8:143884869 A/G cg17252645 chr8:143867129 LY6D -0.32 -5.47 -0.32 1.06e-7 Urinary tract infection frequency; CESC cis rs7917772 0.503 rs746552 chr10:104342501 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.47 0.42 1.15e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg09913183 chr17:42254507 C17orf65;ASB16 0.74 10.2 0.53 8.14e-21 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13195218 chr1:223900468 CAPN2 0.55 6.19 0.36 2.23e-9 Gut microbiome composition (summer); CESC cis rs8060686 0.641 rs9674047 chr16:68045046 G/A cg26727032 chr16:67993705 SLC12A4 -0.53 -6.48 -0.37 4.39e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs2651899 0.902 rs1624023 chr1:3079337 C/T cg22674798 chr1:3096360 PRDM16 0.38 7.42 0.41 1.56e-12 Migraine; CESC cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.5 8.46 0.46 1.84e-15 Monocyte percentage of white cells; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg05979741 chr2:110873485 MALL -0.45 -6.07 -0.35 4.31e-9 Height; CESC cis rs6541297 0.699 rs966333 chr1:230305477 T/C cg20703242 chr1:230279135 GALNT2 0.62 6.93 0.39 3.14e-11 Coronary artery disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05306856 chr1:89357390 GTF2B -0.43 -6.26 -0.36 1.5e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.64 -8.23 -0.45 8.51e-15 Tonsillectomy; CESC cis rs367943 1.000 rs191553 chr5:112823659 A/G cg12552261 chr5:112820674 MCC -0.63 -7.96 -0.44 4.96e-14 Type 2 diabetes; CESC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.45 -0.32 1.17e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs28830936 1.000 rs9672360 chr15:41912411 T/C cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.36 -5.08 -0.3 6.99e-7 Diastolic blood pressure; CESC cis rs2845885 1.000 rs11231698 chr11:63877163 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.88 7.33 0.41 2.72e-12 Body mass index; CESC cis rs8072100 0.544 rs9284377 chr17:45386412 C/T cg08085267 chr17:45401833 C17orf57 -0.53 -6.72 -0.38 1.11e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs34172651 0.917 rs200532 chr16:24756148 C/T cg06028605 chr16:24865363 SLC5A11 -0.35 -5.49 -0.32 9.48e-8 Intelligence (multi-trait analysis); CESC trans rs208520 0.690 rs12198297 chr6:66714665 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.36 0.6 5.09e-28 Exhaled nitric oxide output; CESC cis rs7772486 0.790 rs4314514 chr6:146260010 A/G cg05347473 chr6:146136440 FBXO30 -0.55 -7.0 -0.39 2.12e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6942756 1.000 rs67997229 chr7:128957366 G/C cg02491457 chr7:128862824 NA -0.67 -9.07 -0.49 2.8e-17 White matter hyperintensity burden; CESC cis rs6598955 0.724 rs10902737 chr1:26635716 G/A cg00852783 chr1:26633632 UBXN11 0.43 6.24 0.36 1.76e-9 Obesity-related traits; CESC cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.91e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7520050 0.966 rs6661910 chr1:46290632 A/T cg03146154 chr1:46216737 IPP -0.47 -6.12 -0.35 3.29e-9 Red blood cell count;Reticulocyte count; CESC cis rs6867032 0.958 rs4975795 chr5:2015390 G/A cg26168224 chr5:2018326 NA 0.96 19.34 0.77 1.46e-52 Gut microbiome composition (winter); CESC cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.69 9.01 0.48 4.25e-17 Age-related macular degeneration (geographic atrophy); CESC trans rs3780486 1.000 rs10813957 chr9:33153527 G/T cg04842962 chr6:43655489 MRPS18A 0.93 13.03 0.62 2.49e-30 IgG glycosylation; CESC cis rs2430386 1.000 rs2430386 chr2:63178111 C/T cg17519650 chr2:63277830 OTX1 0.58 8.18 0.45 1.16e-14 Prostate cancer; CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg26668828 chr6:292823 DUSP22 -0.71 -9.3 -0.5 5.31e-18 Menopause (age at onset); CESC cis rs9291683 0.632 rs11734786 chr4:10041499 A/C cg02734326 chr4:10020555 SLC2A9 0.47 6.53 0.37 3.29e-10 Bone mineral density; CESC cis rs926938 0.618 rs3121506 chr1:115363207 T/G cg12756093 chr1:115239321 AMPD1 0.43 5.83 0.34 1.58e-8 Autism; CESC cis rs12477438 0.765 rs6735801 chr2:99657995 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs568617 1.000 rs656980 chr11:65656282 G/A cg00576331 chr11:65640516 EFEMP2 -0.45 -5.35 -0.31 1.95e-7 Crohn's disease; CESC cis rs7103648 0.966 rs896817 chr11:47394305 A/G cg20307385 chr11:47447363 PSMC3 -0.94 -14.48 -0.66 2.09e-35 Diastolic blood pressure;Systolic blood pressure; CESC cis rs13242816 1.000 rs12672717 chr7:116128270 G/A cg04696780 chr7:116139425 CAV2 -0.61 -5.56 -0.32 6.58e-8 P wave duration; CESC cis rs959260 1.000 rs2033607 chr17:73367288 A/G cg20590849 chr17:73267439 MIF4GD -0.53 -6.46 -0.37 5.01e-10 Systemic lupus erythematosus; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14816013 chr12:56618154 OBFC2B -0.41 -6.01 -0.35 6.25e-9 Gambling; CESC cis rs28374715 0.578 rs10518717 chr15:41623368 C/G cg20272979 chr15:41787780 ITPKA 0.45 5.35 0.31 1.89e-7 Ulcerative colitis; CESC cis rs11168351 0.591 rs4258439 chr12:48468652 A/G cg04545296 chr12:48745243 ZNF641 -0.29 -5.44 -0.32 1.18e-7 Bipolar disorder and schizophrenia; CESC cis rs10242455 0.867 rs2037498 chr7:99311550 G/A cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs9916302 0.706 rs801427 chr17:37436711 A/G cg07936489 chr17:37558343 FBXL20 -0.92 -10.41 -0.54 1.65e-21 Glomerular filtration rate (creatinine); CESC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.36 -0.31 1.82e-7 Total body bone mineral density; CESC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs4566357 0.615 rs2272204 chr2:227915601 G/T cg11843606 chr2:227700838 RHBDD1 -0.51 -6.99 -0.39 2.29e-11 Coronary artery disease; CESC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg27094323 chr7:1216898 NA -0.39 -5.53 -0.32 7.74e-8 Longevity;Endometriosis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg26011156 chr1:156183096 PMF1 0.47 6.12 0.35 3.32e-9 Systemic lupus erythematosus; CESC cis rs6598955 0.671 rs17163749 chr1:26568165 A/G cg19743891 chr1:26644573 UBXN11;CD52 0.38 5.38 0.31 1.68e-7 Obesity-related traits; CESC trans rs34132583 0.614 rs74847445 chr4:146367961 A/G cg20655644 chr15:79254454 RASGRF1 0.69 6.14 0.35 2.94e-9 Hippocampal sclerosis; CESC cis rs2228479 0.702 rs12599561 chr16:89894358 C/G cg00800038 chr16:89945340 TCF25 -0.89 -6.88 -0.39 4.34e-11 Skin colour saturation; CESC cis rs12122100 0.507 rs1925343 chr1:146505535 A/T cg03526459 chr1:146549940 NA -0.36 -5.78 -0.33 2.1e-8 HIV-1 control; CESC cis rs11650494 0.831 rs11650886 chr17:47449193 G/A cg08112188 chr17:47440006 ZNF652 1.07 7.52 0.42 8.54e-13 Prostate cancer; CESC cis rs796364 0.951 rs13029537 chr2:200998950 T/C cg23649088 chr2:200775458 C2orf69 -0.52 -5.09 -0.3 6.77e-7 Schizophrenia; CESC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg24549020 chr5:56110836 MAP3K1 -0.5 -6.23 -0.36 1.87e-9 Initial pursuit acceleration; CESC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg06074448 chr4:187884817 NA -0.37 -5.45 -0.32 1.16e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7216064 1.000 rs8067892 chr17:65837983 A/G cg12091567 chr17:66097778 LOC651250 -0.8 -9.08 -0.49 2.62e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs870825 0.616 rs7678864 chr4:185635158 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.89 0.39 3.95e-11 Blood protein levels; CESC cis rs72781680 1.000 rs17762102 chr2:24085606 A/G cg08917208 chr2:24149416 ATAD2B 0.92 8.46 0.46 1.78e-15 Lymphocyte counts; CESC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg18240062 chr17:79603768 NPLOC4 0.54 7.05 0.4 1.56e-11 Eye color traits; CESC cis rs3796352 1.000 rs7622420 chr3:53111069 A/G cg07884673 chr3:53033167 SFMBT1 0.5 5.31 0.31 2.3e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg05863683 chr7:1912471 MAD1L1 0.41 5.93 0.34 9.29e-9 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05318600 chr7:6695121 NA -0.56 -6.25 -0.36 1.63e-9 Gut microbiome composition (summer); CESC cis rs7586879 0.639 rs7580081 chr2:25097072 G/C cg01884057 chr2:25150051 NA 0.38 7.4 0.41 1.85e-12 Body mass index; CESC cis rs854765 0.547 rs8075189 chr17:17901946 C/G cg09796270 chr17:17721594 SREBF1 0.39 5.47 0.32 1.06e-7 Total body bone mineral density; CESC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg25405998 chr7:65216604 CCT6P1 0.52 5.79 0.34 1.99e-8 Aortic root size; CESC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs9287719 0.967 rs9679581 chr2:10751736 G/A cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs7714584 1.000 rs7705542 chr5:150228318 G/A cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs2288912 0.838 rs7251503 chr19:45455715 C/G cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.23e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6800768 0.604 rs75990679 chr3:24155774 G/C cg10674438 chr3:24145617 LOC152024 -0.46 -6.04 -0.35 5.08e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2865126 0.743 rs1941550 chr18:10747590 T/C cg21165219 chr18:10698044 FAM38B -0.51 -5.16 -0.3 4.83e-7 Metabolite levels (5-HIAA/ MHPG Ratio); CESC cis rs1577917 0.958 rs11754330 chr6:86455070 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.53 -6.89 -0.39 4.05e-11 Response to antipsychotic treatment; CESC cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg14393609 chr7:65229607 NA -0.42 -5.49 -0.32 9.38e-8 Aortic root size; CESC cis rs1707322 1.000 rs4660896 chr1:46372416 A/G cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7267979 0.932 rs6115215 chr20:25562500 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.73 12.77 0.62 1.93e-29 Liver enzyme levels (alkaline phosphatase); CESC cis rs16854884 0.586 rs6796460 chr3:143756367 G/A cg06585982 chr3:143692056 C3orf58 0.48 6.6 0.38 2.28e-10 Economic and political preferences (feminism/equality); CESC cis rs2075671 0.855 rs62483567 chr7:100286435 G/A cg20848291 chr7:100343083 ZAN -0.8 -10.07 -0.53 2.04e-20 Other erythrocyte phenotypes; CESC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.48 0.32 9.98e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9325144 0.624 rs7309400 chr12:39150369 G/C cg26384229 chr12:38710491 ALG10B -0.52 -7.12 -0.4 1.02e-11 Morning vs. evening chronotype; CESC cis rs7267979 0.966 rs2227892 chr20:25264814 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.68 8.01 0.44 3.59e-14 Age-related macular degeneration (geographic atrophy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07204069 chr17:72772514 TMEM104;NAT9 0.53 6.12 0.35 3.32e-9 Gut microbiome composition (summer); CESC trans rs61931739 0.534 rs814669 chr12:34102459 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.06 0.4 1.45e-11 Morning vs. evening chronotype; CESC cis rs4835473 0.932 rs4835278 chr4:144709586 T/C cg25736465 chr4:144833511 NA -0.33 -5.35 -0.31 1.87e-7 Immature fraction of reticulocytes; CESC cis rs12042052 0.590 rs72752167 chr1:232922414 G/A cg00951395 chr1:232941775 KIAA1383 0.71 6.48 0.37 4.51e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs2979489 0.699 rs17554116 chr8:30419334 C/T cg26383811 chr8:30366931 RBPMS -0.75 -8.98 -0.48 5.12e-17 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs317689 0.819 rs317667 chr12:69703754 G/T cg14784868 chr12:69753453 YEATS4 0.49 5.22 0.31 3.68e-7 Response to diuretic therapy; CESC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg08888203 chr3:10149979 C3orf24 0.48 6.0 0.35 6.49e-9 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27003951 chr16:11350045 SOCS1 -0.46 -6.46 -0.37 5.12e-10 Fibrinogen levels; CESC cis rs12142240 0.698 rs57267378 chr1:46816644 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs5753037 0.754 rs4820824 chr22:30360915 G/A cg01021169 chr22:30184971 ASCC2 -0.38 -5.91 -0.34 1.02e-8 Type 1 diabetes; CESC cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg02297831 chr4:17616191 MED28 0.44 5.4 0.32 1.45e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9287719 0.967 rs2110776 chr2:10748810 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg17724175 chr1:150552817 MCL1 -0.33 -5.35 -0.31 1.9e-7 Tonsillectomy; CESC cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg20891283 chr12:69753455 YEATS4 0.84 13.12 0.63 1.24e-30 Blood protein levels; CESC cis rs6831352 0.918 rs13140423 chr4:100050400 T/C cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs4820539 0.933 rs2267004 chr22:23459863 G/A cg14186256 chr22:23484241 RTDR1 0.81 14.18 0.66 2.33e-34 Bone mineral density; CESC cis rs6062302 0.522 rs3787112 chr20:62222411 G/A cg06363034 chr20:62225388 GMEB2 -0.52 -6.73 -0.38 1.05e-10 Glioblastoma; CESC trans rs2121875 0.667 rs1550939 chr5:44221712 A/G cg07292773 chr6:156718177 NA -0.47 -6.03 -0.35 5.62e-9 Prostate cancer; CESC cis rs1153858 1.000 rs28679834 chr15:45616206 C/T cg14582100 chr15:45693742 SPATA5L1 0.39 5.47 0.32 1.02e-7 Homoarginine levels; CESC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg23803603 chr1:2058230 PRKCZ -0.34 -5.79 -0.34 1.97e-8 Height; CESC cis rs9287719 0.967 rs7570118 chr2:10718007 G/T cg02196655 chr2:10830764 NOL10 -0.37 -5.64 -0.33 4.43e-8 Prostate cancer; CESC cis rs7617773 0.817 rs4131361 chr3:48328812 T/C cg11946769 chr3:48343235 NME6 0.8 10.89 0.56 4.71e-23 Coronary artery disease; CESC cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg05347473 chr6:146136440 FBXO30 -0.52 -6.29 -0.36 1.32e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs2439831 1.000 rs689781 chr15:43792097 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.17 0.6 2.26e-27 Lung cancer in ever smokers; CESC cis rs1003719 0.788 rs7276917 chr21:38451334 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.63 0.47 5.94e-16 Eye color traits; CESC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg06074448 chr4:187884817 NA -0.38 -5.43 -0.32 1.27e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7429990 0.965 rs4858871 chr3:47953405 A/C cg11946769 chr3:48343235 NME6 0.42 5.13 0.3 5.71e-7 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06103301 chr3:23987730 NR1D2 0.61 7.15 0.4 8.38e-12 Gut microbiome composition (summer); CESC cis rs8027181 0.958 rs4776614 chr15:73082468 C/G cg25632853 chr15:73088954 NA 0.37 6.37 0.36 8.47e-10 Triglyceride levels; CESC cis rs1008375 0.843 rs59112113 chr4:17685336 A/T cg02297831 chr4:17616191 MED28 0.41 5.23 0.31 3.5e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg19468946 chr17:37922297 IKZF3 0.4 5.22 0.31 3.56e-7 Glomerular filtration rate (creatinine); CESC cis rs2243480 1.000 rs4718309 chr7:65627764 G/C cg12463550 chr7:65579703 CRCP -0.73 -5.71 -0.33 3.1e-8 Diabetic kidney disease; CESC cis rs1050631 0.592 rs1010955 chr18:33710610 T/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.19 0.45 1.15e-14 Esophageal squamous cell cancer (length of survival); CESC cis rs7208859 0.623 rs11658022 chr17:29085359 A/T cg19761014 chr17:28927070 LRRC37B2 0.79 6.28 0.36 1.37e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg06766960 chr11:133703094 NA -0.41 -5.87 -0.34 1.28e-8 Childhood ear infection; CESC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg24634471 chr8:143751801 JRK -0.45 -5.06 -0.3 7.96e-7 Urinary tract infection frequency; CESC cis rs9660180 0.620 rs34298494 chr1:1663402 A/C cg13866156 chr1:1669148 SLC35E2 0.49 6.43 0.37 5.98e-10 Body mass index; CESC cis rs367943 0.666 rs10064031 chr5:112970924 C/G cg12552261 chr5:112820674 MCC 0.44 5.63 0.33 4.63e-8 Type 2 diabetes; CESC cis rs8072100 0.738 rs9895509 chr17:45549618 A/T cg08085267 chr17:45401833 C17orf57 0.52 6.65 0.38 1.67e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7116495 1.000 rs12293885 chr11:71816092 T/A cg26138937 chr11:71823887 C11orf51 0.85 6.85 0.39 5.03e-11 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26386643 chr15:74753645 UBL7 0.55 6.02 0.35 5.81e-9 Gut microbiome composition (summer); CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg18337363 chr3:52569053 NT5DC2 0.34 6.66 0.38 1.61e-10 Electroencephalogram traits; CESC cis rs672059 0.513 rs572977 chr1:183164991 C/G ch.1.3577855R chr1:183094577 LAMC1 0.51 6.42 0.37 6.1e-10 Hypertriglyceridemia; CESC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg14159672 chr1:205819179 PM20D1 -0.43 -5.85 -0.34 1.46e-8 Parkinson's disease; CESC cis rs9811920 0.609 rs6765027 chr3:99687730 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.64 -10.1 -0.53 1.73e-20 Axial length; CESC cis rs7772486 0.875 rs2748502 chr6:146298239 A/G cg05347473 chr6:146136440 FBXO30 0.53 7.12 0.4 1.02e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9287719 0.967 rs4669593 chr2:10701908 C/T cg00105475 chr2:10696890 NA 0.39 5.71 0.33 3.1e-8 Prostate cancer; CESC cis rs4909189 1.000 rs62493651 chr7:158135592 T/C cg24154853 chr7:158122151 PTPRN2 0.46 6.2 0.36 2.22e-9 Response to amphetamines; CESC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg13206674 chr6:150067644 NUP43 0.39 5.5 0.32 9.12e-8 Lung cancer; CESC cis rs6433857 0.505 rs1542036 chr2:181350009 A/C cg23363182 chr2:181467187 NA -0.41 -5.94 -0.34 9.11e-9 Body mass index; CESC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg04267008 chr7:1944627 MAD1L1 -0.47 -5.65 -0.33 4.05e-8 Schizophrenia; CESC cis rs9790314 0.967 rs7623206 chr3:160971518 G/A cg04691961 chr3:161091175 C3orf57 -0.4 -5.08 -0.3 7.19e-7 Morning vs. evening chronotype; CESC cis rs6912958 0.781 rs6940150 chr6:88287114 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.58 -0.37 2.55e-10 Monocyte percentage of white cells; CESC cis rs2228479 0.850 rs45567439 chr16:89814604 G/A cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg13206674 chr6:150067644 NUP43 0.43 6.27 0.36 1.44e-9 Lung cancer; CESC cis rs4803468 1.000 rs4803468 chr19:41922352 A/G cg14132834 chr19:41945861 ATP5SL -0.68 -8.41 -0.46 2.55e-15 Height; CESC cis rs2439831 1.000 rs2439850 chr15:43784854 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.25 0.53 5.49e-21 Lung cancer in ever smokers; CESC trans rs12599106 0.707 rs2163977 chr16:34916134 A/G cg05064044 chr6:292385 DUSP22 -0.6 -7.44 -0.42 1.37e-12 Menopause (age at onset); CESC cis rs6480314 0.656 rs2394459 chr10:69981436 C/T cg06988349 chr10:69991859 ATOH7 0.32 5.11 0.3 6.22e-7 Optic nerve measurement (disc area); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12344600 chr6:89769123 NA -0.66 -7.96 -0.44 5.17e-14 Gut microbiome composition (summer); CESC cis rs4642101 0.793 rs56082700 chr3:12833833 T/C cg24848339 chr3:12840334 CAND2 0.34 5.24 0.31 3.28e-7 QRS complex (12-leadsum); CESC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.89 9.93 0.52 5.96e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12545109 0.876 rs4738494 chr8:57327438 G/T cg09654669 chr8:57350985 NA -0.58 -7.07 -0.4 1.37e-11 Obesity-related traits; CESC cis rs9420 0.961 rs71484461 chr11:57488890 G/A cg19752551 chr11:57585705 CTNND1 -0.36 -5.07 -0.3 7.55e-7 Schizophrenia; CESC cis rs887829 0.569 rs4399719 chr2:234666461 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -6.16 -0.35 2.62e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs2594989 0.943 rs2454500 chr3:11500103 C/T cg00170343 chr3:11313890 ATG7 0.56 5.1 0.3 6.55e-7 Circulating chemerin levels; CESC cis rs8017423 0.967 rs4904657 chr14:90721600 A/G cg14092571 chr14:90743983 NA -0.55 -8.25 -0.45 7.71e-15 Mortality in heart failure; CESC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg18016565 chr1:150552671 MCL1 0.34 5.28 0.31 2.67e-7 Tonsillectomy; CESC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg19077165 chr18:44547161 KATNAL2 -0.6 -9.11 -0.49 2.13e-17 Personality dimensions; CESC cis rs863345 0.564 rs11265014 chr1:158503221 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.89 -0.39 4.12e-11 Pneumococcal bacteremia; CESC cis rs9291683 0.609 rs3796836 chr4:10011345 A/G cg02734326 chr4:10020555 SLC2A9 0.5 7.27 0.41 4.15e-12 Bone mineral density; CESC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC trans rs61931739 0.517 rs12367881 chr12:34175508 T/C cg26384229 chr12:38710491 ALG10B 0.66 9.12 0.49 1.89e-17 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03031583 chr16:21964721 UQCRC2 -0.47 -6.69 -0.38 1.3e-10 Gambling; CESC cis rs12142240 0.959 rs12137934 chr1:46728913 A/G cg00530320 chr1:46809349 NSUN4 0.54 6.81 0.39 6.47e-11 Menopause (age at onset); CESC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.9 0.52 7.05e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs9300255 0.722 rs11830103 chr12:123823546 A/G cg00376283 chr12:123451042 ABCB9 -0.58 -6.75 -0.38 9.12e-11 Neutrophil percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22833807 chr22:36925177 EIF3D -0.48 -7.05 -0.4 1.59e-11 Gambling; CESC cis rs1707322 1.000 rs4606257 chr1:46307268 G/A cg05343316 chr1:45956843 TESK2 0.49 5.94 0.34 8.87e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7210086 1.000 rs7210086 chr17:70641698 A/C cg04206342 chr17:70636940 NA -0.35 -5.81 -0.34 1.79e-8 Ulcerative colitis; CESC cis rs7666738 0.819 rs62318904 chr4:99036101 A/T cg18180107 chr4:99064573 C4orf37 0.43 5.4 0.31 1.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs684232 0.583 rs4968094 chr17:507120 A/T cg12384639 chr17:618140 VPS53 0.43 5.57 0.32 6.3e-8 Prostate cancer; CESC cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg23281280 chr6:28129359 ZNF389 -0.52 -6.88 -0.39 4.4e-11 Parkinson's disease; CESC cis rs959260 0.858 rs2053156 chr17:73378440 G/T cg12999837 chr17:73267436 MIF4GD -0.48 -5.57 -0.32 6.3e-8 Systemic lupus erythematosus; CESC cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg18180107 chr4:99064573 C4orf37 0.43 5.07 0.3 7.33e-7 Colonoscopy-negative controls vs population controls; CESC cis rs68170813 0.523 rs11762152 chr7:106811374 G/A cg02696742 chr7:106810147 HBP1 -0.58 -5.75 -0.33 2.45e-8 Coronary artery disease; CESC cis rs7927592 0.956 rs11228251 chr11:68244558 G/T cg20283391 chr11:68216788 NA -0.5 -6.4 -0.37 7e-10 Total body bone mineral density; CESC cis rs9815354 1.000 rs6763829 chr3:41897046 A/G cg03022575 chr3:42003672 ULK4 0.45 5.2 0.3 3.99e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg07167872 chr1:205819463 PM20D1 0.79 12.48 0.61 2.06e-28 Menarche (age at onset); CESC cis rs7560272 0.588 rs4852965 chr2:73911169 T/C cg20560298 chr2:73613845 ALMS1 0.49 6.88 0.39 4.23e-11 Schizophrenia; CESC trans rs11098499 0.954 rs6822679 chr4:120402702 A/C cg25214090 chr10:38739885 LOC399744 0.72 10.21 0.53 7.58e-21 Corneal astigmatism; CESC cis rs225245 0.755 rs226441 chr17:34033072 C/T cg05299278 chr17:33885742 SLFN14 0.38 5.43 0.32 1.27e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs3087591 0.887 rs2905796 chr17:29537586 G/A cg24425628 chr17:29625626 OMG;NF1 0.42 5.03 0.3 9.22e-7 Hip circumference; CESC cis rs10832963 1.000 rs10832962 chr11:18656271 C/T cg20219074 chr11:18656078 SPTY2D1 0.8 11.7 0.58 9.24e-26 Breast cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14161438 chr18:72920197 ZADH2 0.48 6.78 0.38 7.81e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.55 0.37 2.91e-10 Prudent dietary pattern; CESC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg17971929 chr21:40555470 PSMG1 -0.84 -12.15 -0.6 2.69e-27 Cognitive function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02196227 chr4:89080292 ABCG2 0.42 6.16 0.35 2.69e-9 Gut microbiota (bacterial taxa); CESC cis rs1348850 0.567 rs3770011 chr2:178537890 C/T cg23306229 chr2:178417860 TTC30B 0.51 6.16 0.35 2.68e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11098499 0.780 rs7680914 chr4:120563053 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.47 0.5 1.66e-18 Corneal astigmatism; CESC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg14562523 chr21:43528734 C21orf128;UMODL1 -0.46 -7.17 -0.4 7.32e-12 IgG glycosylation; CESC cis rs34779708 0.931 rs35848945 chr10:35287561 G/T cg04310649 chr10:35416472 CREM -0.48 -5.78 -0.33 2.07e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs10751667 0.666 rs7943140 chr11:973824 T/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.32 -0.31 2.24e-7 Alzheimer's disease (late onset); CESC cis rs17407555 0.647 rs55811736 chr4:10014221 G/A cg11266682 chr4:10021025 SLC2A9 -0.51 -6.08 -0.35 4.18e-9 Schizophrenia (age at onset); CESC cis rs1348850 0.574 rs13431105 chr2:178434674 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 5.39 0.31 1.57e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15232450 chr3:4345438 SETMAR -0.41 -6.1 -0.35 3.66e-9 Gambling; CESC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Tonsillectomy; CESC cis rs73206853 0.841 rs28480627 chr12:110834659 T/C cg12870014 chr12:110450643 ANKRD13A 0.63 5.23 0.31 3.48e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs8002861 0.754 rs7330760 chr13:44403088 A/T cg19180546 chr13:44453867 C13orf31;CCDC122 -0.39 -5.12 -0.3 6.01e-7 Leprosy; CESC cis rs10789491 1.000 rs1545206 chr1:47185082 C/G cg15501359 chr1:47185051 KIAA0494 0.82 9.02 0.48 3.92e-17 Response to hepatitis C treatment; CESC cis rs2295499 0.673 rs55688738 chr4:2704628 G/C cg27239842 chr4:2403781 ZFYVE28 -0.33 -5.54 -0.32 7.32e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs1580019 0.523 rs9791770 chr7:32582252 C/A cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.45 0.37 5.36e-10 Cognitive ability; CESC cis rs4654899 1.000 rs6659152 chr1:21355841 C/G cg05370193 chr1:21551575 ECE1 0.4 6.14 0.35 3.03e-9 Superior frontal gyrus grey matter volume; CESC cis rs11718455 0.960 rs13083325 chr3:44005333 T/C cg08738300 chr3:44038990 NA 0.46 6.12 0.35 3.34e-9 Coronary artery disease; CESC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg25036284 chr2:26402008 FAM59B -0.58 -6.73 -0.38 1.04e-10 Gut microbiome composition (summer); CESC cis rs10129255 0.785 rs10150044 chr14:107183934 T/A cg23076370 chr14:107095027 NA -0.47 -6.15 -0.35 2.81e-9 Kawasaki disease; CESC cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg21854759 chr1:92012499 NA -0.52 -5.71 -0.33 3.02e-8 Eosinophil percentage of white cells; CESC cis rs4727027 0.901 rs11760293 chr7:148811725 A/G cg23583168 chr7:148888333 NA -0.79 -12.22 -0.6 1.51e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs523522 0.892 rs4767916 chr12:121024032 T/C cg27279351 chr12:120934652 DYNLL1 0.69 8.86 0.48 1.2e-16 High light scatter reticulocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03925809 chr19:6393419 GTF2F1 0.47 6.6 0.38 2.22e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4237845 0.804 rs11172372 chr12:58286273 T/C cg02175503 chr12:58329896 NA 0.62 8.94 0.48 6.68e-17 Intelligence (multi-trait analysis); CESC cis rs12451471 0.637 rs7567 chr17:78093549 G/T cg24585782 chr17:78113791 EIF4A3 -0.61 -7.91 -0.44 6.83e-14 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs7762018 0.556 rs78233989 chr6:170102041 C/G cg19338460 chr6:170058176 WDR27 -1.04 -8.47 -0.46 1.75e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.92 -0.34 1e-8 Parkinson's disease; CESC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg14393609 chr7:65229607 NA 0.52 6.98 0.39 2.33e-11 Calcium levels; CESC cis rs7084402 0.934 rs1658471 chr10:60291911 A/T cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs7809950 0.678 rs2107317 chr7:106899685 T/C cg23024343 chr7:107201750 COG5 -0.54 -6.86 -0.39 4.86e-11 Coronary artery disease; CESC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg24562669 chr7:97807699 LMTK2 0.48 7.1 0.4 1.13e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs611744 0.538 rs13257548 chr8:109273185 G/A cg21045802 chr8:109455806 TTC35 0.56 6.95 0.39 2.89e-11 Dupuytren's disease; CESC cis rs2243480 0.522 rs12698511 chr7:65474919 G/T cg13147721 chr7:65941812 NA -0.84 -6.4 -0.37 6.86e-10 Diabetic kidney disease; CESC cis rs477692 0.905 rs576560 chr10:131420697 C/A cg05714579 chr10:131428358 MGMT 0.55 7.88 0.44 8.39e-14 Response to temozolomide; CESC cis rs9611565 0.592 rs5996038 chr22:41965300 T/C cg17376030 chr22:41985996 PMM1 0.54 5.98 0.35 7.02e-9 Vitiligo; CESC cis rs909002 0.800 rs11589306 chr1:32082822 C/G cg13919466 chr1:32135498 COL16A1 -0.46 -8.26 -0.45 6.82e-15 Intelligence (multi-trait analysis); CESC cis rs17376456 0.757 rs6859757 chr5:93206042 C/T cg21475434 chr5:93447410 FAM172A 0.86 7.46 0.42 1.2e-12 Diabetic retinopathy; CESC cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg23711669 chr6:146136114 FBXO30 1.02 15.96 0.7 1.2e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.875 rs2224121 chr6:146343214 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.36 0.36 8.84e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs763121 0.853 rs35565791 chr22:39063011 C/A cg14440974 chr22:39074834 NA -0.42 -5.82 -0.34 1.69e-8 Menopause (age at onset); CESC cis rs6570726 0.935 rs447818 chr6:145868996 C/T cg05347473 chr6:146136440 FBXO30 0.46 6.16 0.35 2.72e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs920590 0.684 rs59259846 chr8:19669468 C/G cg01411142 chr8:19674711 INTS10 0.56 6.19 0.36 2.24e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs9900062 1.000 rs2521879 chr17:62742678 A/G cg02598441 chr17:62777298 LOC146880 -0.5 -5.27 -0.31 2.87e-7 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20149956 chr1:249132233 ZNF672 0.55 6.71 0.38 1.18e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13520342 chr11:18230799 LOC494141 -0.43 -6.1 -0.35 3.72e-9 Gut microbiome composition (summer); CESC cis rs1707322 0.752 rs11211145 chr1:46108491 A/C cg05343316 chr1:45956843 TESK2 0.47 5.39 0.31 1.57e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9660992 0.674 rs72745219 chr1:205262271 G/A cg00857998 chr1:205179979 DSTYK 0.49 5.51 0.32 8.52e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs10876993 0.928 rs2928053 chr12:58063475 T/C cg18357645 chr12:58087776 OS9 0.64 10.4 0.54 1.75e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs2204008 0.811 rs11520277 chr12:38359611 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.77 0.33 2.24e-8 Bladder cancer; CESC cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg02079420 chr8:82753780 SNX16 -0.58 -7.74 -0.43 2.15e-13 Diastolic blood pressure; CESC cis rs7639513 0.767 rs7617041 chr3:12709167 A/G cg23032965 chr3:12705835 RAF1 0.76 10.86 0.55 5.83e-23 Itch intensity from mosquito bite; CESC cis rs12950390 0.853 rs12450729 chr17:45855363 A/G cg00777063 chr17:45855553 NA -0.39 -5.74 -0.33 2.62e-8 IgG glycosylation; CESC cis rs10883723 0.810 rs10748823 chr10:104274465 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.58 0.42 5.73e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs1801251 1.000 rs1801251 chr2:233633460 G/A cg25237894 chr2:233734115 C2orf82 0.45 7.9 0.44 7.6e-14 Coronary artery disease; CESC cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg19193384 chr17:30244184 NA -0.7 -6.34 -0.36 9.87e-10 Hip circumference adjusted for BMI; CESC trans rs8060598 0.548 rs4785453 chr16:50842162 C/T cg00849365 chr16:5074999 NAGPA -0.38 -6.16 -0.35 2.71e-9 Leprosy; CESC cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2073300 0.609 rs6137938 chr20:23389127 C/G cg16736954 chr20:23401023 NAPB 0.76 6.0 0.35 6.44e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6460942 1.000 rs17274870 chr7:12406221 G/T cg02935154 chr7:12443704 VWDE -0.57 -5.89 -0.34 1.16e-8 Coronary artery disease; CESC cis rs17826219 0.636 rs12946563 chr17:29103166 C/G cg13385521 chr17:29058706 SUZ12P 0.77 6.15 0.35 2.81e-9 Body mass index; CESC trans rs5756813 0.754 rs762982 chr22:38144235 A/G cg19894588 chr14:64061835 NA 0.66 7.67 0.43 3.21e-13 Optic cup area;Vertical cup-disc ratio; CESC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg04944784 chr2:26401820 FAM59B -0.66 -7.62 -0.42 4.62e-13 Gut microbiome composition (summer); CESC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 8.38 0.46 3.05e-15 Intelligence (multi-trait analysis); CESC cis rs4969178 0.965 rs12451715 chr17:76397334 A/C cg20026190 chr17:76395443 PGS1 0.49 7.81 0.43 1.34e-13 HDL cholesterol levels; CESC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.84 -11.65 -0.58 1.38e-25 Alzheimer's disease; CESC cis rs6831352 0.840 rs17817868 chr4:100060623 C/T cg12011299 chr4:100065546 ADH4 -0.59 -6.59 -0.38 2.35e-10 Alcohol dependence; CESC cis rs4727027 0.522 rs6956736 chr7:148893472 G/C cg23583168 chr7:148888333 NA -0.81 -10.14 -0.53 1.28e-20 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs992157 0.560 rs6436048 chr2:219109033 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.58 7.26 0.41 4.4e-12 Colorectal cancer; CESC cis rs4835937 0.670 rs10064559 chr5:127329683 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.56 5.08 0.3 7.26e-7 Cancer; CESC cis rs6952808 0.931 rs12537479 chr7:1868995 A/G cg04267008 chr7:1944627 MAD1L1 0.55 6.72 0.38 1.11e-10 Bipolar disorder and schizophrenia; CESC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg09323728 chr8:95962352 TP53INP1 -0.43 -9.53 -0.51 1.07e-18 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19155557 chr3:41240643 CTNNB1 -0.52 -7.34 -0.41 2.61e-12 Gut microbiota (bacterial taxa); CESC cis rs9581857 0.579 rs76657892 chr13:27997604 A/G cg22138327 chr13:27999177 GTF3A 0.64 5.43 0.32 1.26e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg11366901 chr6:160182831 ACAT2 -0.84 -10.96 -0.56 2.59e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs1707322 0.758 rs10789474 chr1:46250040 G/T cg06784218 chr1:46089804 CCDC17 0.37 6.34 0.36 1e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21314839 chr13:114782035 RASA3 0.44 6.29 0.36 1.31e-9 Fibrinogen levels; CESC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.47 0.64 7.58e-32 Prudent dietary pattern; CESC cis rs9457247 0.565 rs2239823 chr6:167512131 T/C cg23791538 chr6:167370224 RNASET2 -0.54 -7.06 -0.4 1.48e-11 Crohn's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09698166 chr20:21106763 PLK1S1 -0.42 -6.3 -0.36 1.21e-9 Gambling; CESC cis rs1461503 0.932 rs10892944 chr11:122843895 T/C cg27398637 chr11:122830231 C11orf63 -0.55 -8.26 -0.45 7.22e-15 Menarche (age at onset); CESC cis rs7666738 0.830 rs9884501 chr4:98893721 A/C cg17366294 chr4:99064904 C4orf37 0.55 7.59 0.42 5.41e-13 Colonoscopy-negative controls vs population controls; CESC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.76 0.55 1.2e-22 Height; CESC cis rs854765 0.964 rs854810 chr17:18006421 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.47 -5.98 -0.34 7.09e-9 Total body bone mineral density; CESC cis rs9322193 0.886 rs9767555 chr6:149968158 T/C cg13206674 chr6:150067644 NUP43 0.37 5.18 0.3 4.36e-7 Lung cancer; CESC cis rs17293817 0.618 rs35057480 chr10:1430947 A/T cg04271617 chr10:1416546 ADARB2 0.33 5.05 0.3 8.1e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 14.1 0.65 4.76e-34 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01849047 chr16:3646322 BTBD12 -0.52 -6.14 -0.35 3.07e-9 Gut microbiome composition (summer); CESC cis rs4899260 0.779 rs4899261 chr14:69283375 C/T cg03189333 chr14:69283534 NA -0.44 -5.03 -0.3 8.88e-7 Celiac disease; CESC cis rs763121 0.853 rs4821816 chr22:39113134 G/A cg14440974 chr22:39074834 NA -0.35 -5.13 -0.3 5.71e-7 Menopause (age at onset); CESC cis rs34779708 0.966 rs4934734 chr10:35434373 T/C cg03585969 chr10:35415529 CREM 0.75 9.84 0.52 1.09e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs7923609 1.000 rs10761723 chr10:64955581 C/T cg01631684 chr10:65280961 REEP3 -0.45 -5.56 -0.32 6.51e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02621907 chr5:93954419 ANKRD32;C5orf36 -0.46 -6.74 -0.38 1e-10 Gambling; CESC cis rs909002 0.742 rs12032291 chr1:32129041 A/G cg13919466 chr1:32135498 COL16A1 0.43 7.47 0.42 1.19e-12 Intelligence (multi-trait analysis); CESC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg08888203 chr3:10149979 C3orf24 0.41 5.77 0.33 2.15e-8 Alzheimer's disease; CESC cis rs11098499 0.954 rs56270433 chr4:120406030 C/T cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.1e-8 Corneal astigmatism; CESC cis rs3857067 0.806 rs6532471 chr4:95108584 T/C cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.05 -0.49 3.25e-17 QT interval; CESC cis rs7927771 0.507 rs10838759 chr11:47785347 T/C cg18512352 chr11:47633146 NA 0.34 5.3 0.31 2.38e-7 Subjective well-being; CESC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg22920501 chr2:26401640 FAM59B -0.66 -7.93 -0.44 6.28e-14 Gut microbiome composition (summer); CESC cis rs12618769 0.652 rs4851146 chr2:99237439 A/G cg10123293 chr2:99228465 UNC50 0.42 5.58 0.32 6.08e-8 Bipolar disorder; CESC trans rs5756813 0.754 rs5750495 chr22:38179120 T/A cg19894588 chr14:64061835 NA 0.67 8.47 0.46 1.76e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg11764359 chr7:65958608 NA -0.92 -14.66 -0.67 5e-36 Aortic root size; CESC cis rs1048257 0.553 rs2819421 chr14:105408811 A/G cg15352829 chr14:105391018 PLD4 -0.58 -9.88 -0.52 8.19e-20 Systemic lupus erythematosus; CESC trans rs10895547 0.527 rs559828 chr11:103790829 C/T cg23613023 chr12:115353932 NA -0.38 -6.22 -0.36 1.96e-9 LDL cholesterol; CESC cis rs1348850 0.958 rs11684320 chr2:178456346 T/C cg23306229 chr2:178417860 TTC30B 0.57 7.44 0.42 1.43e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7666738 0.830 rs4699580 chr4:98930673 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC cis rs3862030 0.720 rs7341995 chr10:104223831 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.38 -5.23 -0.31 3.51e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs10781543 0.817 rs1128874 chr9:139323424 T/C cg14169450 chr9:139327907 INPP5E 0.55 8.62 0.47 6.16e-16 Monocyte percentage of white cells; CESC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg12648201 chr2:27665141 KRTCAP3 -0.31 -5.76 -0.33 2.37e-8 Total body bone mineral density; CESC cis rs847577 0.609 rs11768309 chr7:97773812 G/T cg24562669 chr7:97807699 LMTK2 0.85 14.61 0.67 7.13e-36 Breast cancer; CESC cis rs113835537 0.529 rs11227511 chr11:66281244 A/C cg24851651 chr11:66362959 CCS 0.43 5.38 0.31 1.63e-7 Airway imaging phenotypes; CESC trans rs11098499 1.000 rs11726229 chr4:120211580 C/T cg25214090 chr10:38739885 LOC399744 0.68 9.37 0.5 3.4e-18 Corneal astigmatism; CESC cis rs11098499 0.863 rs3733525 chr4:120447048 A/G cg09307838 chr4:120376055 NA 0.92 12.61 0.61 7.4e-29 Corneal astigmatism; CESC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.79 -0.39 7.19e-11 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg08968635 chr6:28129556 ZNF389 0.39 5.14 0.3 5.33e-7 Depression; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03239202 chr2:68694299 FBXO48;APLF 0.49 6.09 0.35 4e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7520050 0.751 rs2230657 chr1:46073489 G/A cg24296786 chr1:45957014 TESK2 0.47 5.78 0.33 2.05e-8 Red blood cell count;Reticulocyte count; CESC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.34 0.5 3.98e-18 Menopause (age at onset); CESC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg17143192 chr8:8559678 CLDN23 0.74 8.73 0.47 2.86e-16 Obesity-related traits; CESC cis rs7129220 0.512 rs2119991 chr11:10226268 A/G cg01453529 chr11:10209919 SBF2 -0.47 -5.79 -0.33 2.01e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs12599106 0.707 rs2163977 chr16:34916134 A/G cg01171360 chr6:293285 DUSP22 -0.63 -8.12 -0.45 1.81e-14 Menopause (age at onset); CESC cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg06212747 chr3:49208901 KLHDC8B 0.73 10.06 0.53 2.28e-20 Parkinson's disease; CESC cis rs950776 0.518 rs12902493 chr15:78819275 C/G cg06917634 chr15:78832804 PSMA4 0.76 11.15 0.57 6.26e-24 Sudden cardiac arrest; CESC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg08888203 chr3:10149979 C3orf24 -0.43 -5.71 -0.33 3.08e-8 Alzheimer's disease; CESC cis rs1451375 0.794 rs11238133 chr7:50542914 A/C cg18232548 chr7:50535776 DDC -0.42 -5.34 -0.31 2e-7 Malaria; CESC cis rs12477438 0.798 rs17708218 chr2:99696284 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -10.79 -0.55 9.43e-23 Chronic sinus infection; CESC cis rs910316 0.737 rs175055 chr14:75488946 T/G cg16144293 chr14:75469539 EIF2B2 0.4 5.36 0.31 1.81e-7 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21702128 chr5:142784721 NR3C1 -0.44 -6.21 -0.36 2.03e-9 Gambling; CESC cis rs7481584 0.962 rs11024759 chr11:2982092 T/C cg25174290 chr11:3078921 CARS -0.49 -5.94 -0.34 8.74e-9 Calcium levels; CESC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg19163074 chr7:65112434 INTS4L2 -0.43 -5.34 -0.31 2e-7 Aortic root size; CESC cis rs765787 0.530 rs2554455 chr15:45521304 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -6.88 -0.39 4.36e-11 Uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12126796 chr10:123687380 ATE1 0.64 7.01 0.4 2.02e-11 Gut microbiome composition (summer); CESC trans rs11098499 0.818 rs12498599 chr4:120468503 C/T cg25214090 chr10:38739885 LOC399744 0.67 9.21 0.49 1.05e-17 Corneal astigmatism; CESC cis rs6484504 0.553 rs413067 chr11:31223497 T/C cg14844989 chr11:31128820 NA -0.42 -5.96 -0.34 7.83e-9 Red blood cell count; CESC cis rs2282802 0.685 rs2337082 chr5:139649201 G/A cg26211634 chr5:139558579 C5orf32 0.52 7.49 0.42 1.05e-12 Intelligence (multi-trait analysis); CESC cis rs7191700 0.836 rs28502009 chr16:11426541 G/A cg00044050 chr16:11439710 C16orf75 0.48 5.65 0.33 4.2e-8 Multiple sclerosis; CESC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg03351412 chr1:154909251 PMVK -0.49 -6.11 -0.35 3.45e-9 Prostate cancer; CESC cis rs8141529 0.732 rs5762815 chr22:29205076 A/G cg02153584 chr22:29168773 CCDC117 0.68 9.65 0.51 4.34e-19 Lymphocyte counts; CESC trans rs9325144 0.555 rs7960411 chr12:38703019 A/G cg23762105 chr12:34175262 ALG10 0.49 6.38 0.36 7.75e-10 Morning vs. evening chronotype; CESC trans rs9325144 0.723 rs1586373 chr12:39181582 G/A cg23762105 chr12:34175262 ALG10 0.45 6.14 0.35 3.01e-9 Morning vs. evening chronotype; CESC cis rs2354432 0.607 rs1530336 chr1:146685121 G/A cg25205988 chr1:146714368 CHD1L 1.15 8.65 0.47 4.98e-16 Mitochondrial DNA levels; CESC cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg05585544 chr11:47624801 NA 0.41 6.06 0.35 4.76e-9 Subjective well-being; CESC cis rs950169 0.922 rs4842946 chr15:84942331 G/A cg17507749 chr15:85114479 UBE2QP1 0.59 6.52 0.37 3.46e-10 Schizophrenia; CESC cis rs9815354 0.627 rs80120812 chr3:42021760 C/T cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg05863683 chr7:1912471 MAD1L1 0.37 5.39 0.31 1.56e-7 Bipolar disorder and schizophrenia; CESC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg03806693 chr22:41940476 POLR3H -1.07 -13.69 -0.64 1.25e-32 Vitiligo; CESC cis rs763121 0.853 rs5750649 chr22:39036769 T/C cg06022373 chr22:39101656 GTPBP1 0.95 17.36 0.73 1.37e-45 Menopause (age at onset); CESC cis rs9926296 0.609 rs4785709 chr16:89796665 G/A cg27121462 chr16:89883253 FANCA -0.58 -7.04 -0.4 1.62e-11 Vitiligo; CESC cis rs501120 0.925 rs1746049 chr10:44776310 C/T cg09554077 chr10:44749378 NA 0.57 6.56 0.37 2.84e-10 Coronary artery disease;Coronary heart disease; CESC cis rs6912958 0.781 rs9450712 chr6:88193175 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -5.92 -0.34 1e-8 Monocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24027378 chr17:46103806 COPZ2 -0.42 -6.06 -0.35 4.67e-9 Gut microbiota (bacterial taxa); CESC cis rs1832871 0.711 rs9457264 chr6:158689367 G/A cg07165851 chr6:158734300 TULP4 0.59 6.23 0.36 1.87e-9 Height; CESC cis rs67311347 1.000 rs12630072 chr3:40517190 T/G cg24209194 chr3:40518798 ZNF619 0.5 6.15 0.35 2.84e-9 Renal cell carcinoma; CESC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg04944784 chr2:26401820 FAM59B 0.64 7.09 0.4 1.24e-11 Gut microbiome composition (summer); CESC cis rs763512 0.504 rs58201617 chr17:35865451 G/T cg16670864 chr17:35848621 DUSP14 0.46 5.76 0.33 2.35e-8 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs854765 0.718 rs6502629 chr17:17869642 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.48 6.28 0.36 1.39e-9 Total body bone mineral density; CESC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg19346786 chr7:2764209 NA 0.51 7.51 0.42 8.81e-13 Height; CESC cis rs7914558 0.966 rs11191471 chr10:104702050 T/A cg08650961 chr10:104748594 CNNM2 0.32 5.06 0.3 7.88e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs3733585 0.605 rs4235355 chr4:10123078 C/A cg11266682 chr4:10021025 SLC2A9 -0.57 -10.59 -0.55 4.39e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9911578 1.000 rs654778 chr17:56736473 A/C cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC cis rs62005083 1.000 rs72725916 chr14:74508858 A/G cg05179529 chr14:74551516 LIN52;ALDH6A1 0.7 5.22 0.31 3.68e-7 Mean corpuscular volume; CESC cis rs9527 0.637 rs12219247 chr10:104613361 A/G cg04362960 chr10:104952993 NT5C2 0.51 6.36 0.36 8.64e-10 Arsenic metabolism; CESC cis rs10791323 0.572 rs4412766 chr11:133742811 A/C cg15485101 chr11:133734466 NA 0.32 5.5 0.32 8.87e-8 Childhood ear infection; CESC cis rs2204008 0.728 rs12369538 chr12:38443942 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.28 0.53 4.42e-21 Bladder cancer; CESC cis rs7223966 1.000 rs9899788 chr17:61756384 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.42 0.41 1.55e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs763121 0.853 rs5757203 chr22:39044152 G/C cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.79 12.22 0.6 1.56e-27 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1941023 0.584 rs2014121 chr11:60156297 T/C cg08716584 chr11:60157161 MS4A7 -0.6 -10.18 -0.53 9e-21 Congenital heart disease (maternal effect); CESC cis rs34779708 0.733 rs12249814 chr10:35542757 T/C cg04310649 chr10:35416472 CREM -0.47 -5.39 -0.31 1.59e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs1152591 0.524 rs1255991 chr14:64661642 G/A cg21174375 chr14:64681225 SYNE2 0.55 7.84 0.43 1.13e-13 Atrial fibrillation; CESC cis rs9929218 1.000 rs17772363 chr16:68788909 G/T cg02972257 chr16:68554789 NA 0.53 6.08 0.35 4.07e-9 Colorectal cancer; CESC trans rs208520 0.690 rs2144081 chr6:66824972 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -12.92 -0.62 5.99e-30 Exhaled nitric oxide output; CESC cis rs2070488 0.775 rs11926767 chr3:38527913 A/G cg24069376 chr3:38537580 EXOG -0.33 -5.47 -0.32 1.05e-7 Electrocardiographic conduction measures; CESC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg22143856 chr6:28129313 ZNF389 0.46 5.83 0.34 1.58e-8 Depression; CESC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg19717773 chr7:2847554 GNA12 0.42 6.19 0.36 2.25e-9 Height; CESC cis rs854765 0.647 rs854770 chr17:18019048 A/G cg16928487 chr17:17741425 SREBF1 -0.46 -7.29 -0.41 3.49e-12 Total body bone mineral density; CESC cis rs2228479 0.557 rs34420680 chr16:89809171 C/T cg14709524 chr16:89940631 TCF25 0.94 6.97 0.39 2.46e-11 Skin colour saturation; CESC cis rs727563 0.636 rs2413653 chr22:42106996 T/C cg17376030 chr22:41985996 PMM1 -0.78 -8.43 -0.46 2.23e-15 Crohn's disease;Inflammatory bowel disease; CESC cis rs5769765 1.000 rs5770742 chr22:50270309 T/C cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs6991838 0.584 rs14213 chr8:66514954 C/T cg13398993 chr8:66546079 ARMC1 0.45 5.39 0.31 1.58e-7 Intelligence (multi-trait analysis); CESC cis rs10876993 0.855 rs1689601 chr12:58049557 G/A cg18357645 chr12:58087776 OS9 0.6 9.28 0.5 6.25e-18 Celiac disease or Rheumatoid arthritis; CESC cis rs6674176 0.628 rs12145999 chr1:44428632 C/T cg13606994 chr1:44402422 ARTN -0.38 -5.64 -0.33 4.28e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg08888203 chr3:10149979 C3orf24 0.55 7.2 0.4 6.16e-12 Alzheimer's disease; CESC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg22823121 chr1:150693482 HORMAD1 0.4 5.7 0.33 3.2e-8 Melanoma; CESC cis rs2710642 0.564 rs9989741 chr2:62828377 T/A cg17519650 chr2:63277830 OTX1 0.48 6.38 0.36 7.95e-10 LDL cholesterol levels;LDL cholesterol; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G ch.12.74620632F chr12:76334365 NA 0.47 6.21 0.36 2.01e-9 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22416051 chr7:157455196 PTPRN2 -0.48 -6.49 -0.37 4.2e-10 Gut microbiome composition (summer); CESC cis rs55728055 0.661 rs9619215 chr22:32042732 A/G cg01338084 chr22:32026380 PISD 1.06 7.93 0.44 6.25e-14 Age-related hearing impairment; CESC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg12963246 chr6:28129442 ZNF389 0.59 7.68 0.43 3e-13 Parkinson's disease; CESC cis rs7208859 0.623 rs6505207 chr17:29076571 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9815354 0.904 rs73073368 chr3:41843391 A/G cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs977987 0.843 rs28655617 chr16:75489642 G/A cg03315344 chr16:75512273 CHST6 0.44 6.4 0.37 7.1e-10 Dupuytren's disease; CESC cis rs4595586 0.545 rs1607042 chr12:39368028 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03402994 chr4:984131 SLC26A1;IDUA 0.45 6.19 0.36 2.25e-9 Fibrinogen levels; CESC trans rs2388082 1.000 rs75787187 chr13:29962905 G/T cg18754342 chr12:14849268 GUCY2C -0.66 -6.18 -0.35 2.44e-9 Insomnia (caffeine-induced); CESC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg22590775 chr19:49891494 CCDC155 0.59 7.01 0.4 2e-11 Multiple sclerosis; CESC cis rs2286503 0.752 rs6461669 chr7:22858066 T/G cg13679077 chr7:22862647 TOMM7 0.52 6.72 0.38 1.11e-10 Fibrinogen; CESC cis rs4253772 0.530 rs715518 chr22:46754177 C/G cg24881330 chr22:46731750 TRMU 0.8 5.71 0.33 3.03e-8 LDL cholesterol;Cholesterol, total; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01736252 chr1:55181557 TTC4 -0.4 -6.3 -0.36 1.26e-9 Gambling; CESC cis rs742614 0.533 rs6059496 chr20:32446931 T/C cg06304546 chr20:32448765 NA -0.49 -6.22 -0.36 1.92e-9 Stearic acid (18:0) levels; CESC cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg23711669 chr6:146136114 FBXO30 0.99 14.93 0.68 5.61e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs9894429 0.809 rs9889642 chr17:79591762 T/C cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.98e-8 Eye color traits; CESC cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg04455712 chr21:45112962 RRP1B 0.4 6.09 0.35 3.98e-9 Mean corpuscular volume; CESC trans rs16949788 1.000 rs41306345 chr15:66782048 C/T cg23949574 chr2:240302855 HDAC4 0.44 6.0 0.35 6.53e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4853012 0.838 rs2177707 chr2:74356850 A/G cg19729930 chr2:74357872 NA 0.91 12.88 0.62 8.64e-30 Gestational age at birth (maternal effect); CESC cis rs9815354 1.000 rs1016669 chr3:41894440 T/C cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.48e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7208859 0.623 rs9893422 chr17:29111715 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg23958373 chr8:599963 NA 0.81 5.88 0.34 1.26e-8 IgG glycosylation; CESC cis rs9640161 0.789 rs60283368 chr7:150023258 G/A cg21361702 chr7:150065534 REPIN1 0.46 5.4 0.31 1.46e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs1775715 0.644 rs2799022 chr10:32137198 C/T cg18675610 chr10:32216311 ARHGAP12 0.33 5.09 0.3 6.66e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg14893161 chr1:205819251 PM20D1 0.88 14.21 0.66 1.84e-34 Menarche (age at onset); CESC cis rs3106136 0.967 rs35670996 chr4:95199479 C/G cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.13 -0.4 9.29e-12 Capecitabine sensitivity; CESC cis rs34779708 0.966 rs10827491 chr10:35427395 G/A cg03585969 chr10:35415529 CREM 0.76 10.3 0.53 3.72e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg12463550 chr7:65579703 CRCP 0.44 5.75 0.33 2.48e-8 Aortic root size; CESC cis rs2302777 0.507 rs9889716 chr17:38108298 A/G cg17467752 chr17:38218738 THRA 0.41 5.11 0.3 6.17e-7 Multiple myeloma (hyperdiploidy); CESC cis rs6933660 0.720 rs6913515 chr6:151753470 G/C cg10883421 chr6:151773342 RMND1;C6orf211 0.83 13.61 0.64 2.37e-32 Menarche (age at onset); CESC cis rs4891159 0.584 rs690397 chr18:74117767 C/T cg24786174 chr18:74118243 ZNF516 0.85 16.07 0.7 4.75e-41 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01554580 chr3:47324306 KIF9;KLHL18 0.56 6.02 0.35 5.7e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00291003 chr10:75541506 CHCHD1 0.45 6.1 0.35 3.78e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7084402 0.967 rs1658438 chr10:60326583 A/G cg07615347 chr10:60278583 BICC1 -0.61 -9.62 -0.51 5.36e-19 Refractive error; CESC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg17724175 chr1:150552817 MCL1 -0.51 -8.12 -0.45 1.73e-14 Urate levels; CESC cis rs2243480 1.000 rs313832 chr7:65550891 G/T cg13147721 chr7:65941812 NA -1.02 -9.75 -0.51 2.11e-19 Diabetic kidney disease; CESC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg26335602 chr6:28129616 ZNF389 0.54 7.2 0.4 6.09e-12 Depression; CESC cis rs4969178 1.000 rs4969178 chr17:76388202 C/T cg20026190 chr17:76395443 PGS1 -0.4 -6.3 -0.36 1.21e-9 HDL cholesterol levels; CESC cis rs9902453 0.765 rs1531553 chr17:28066752 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.76 -10.21 -0.53 7.5e-21 Coffee consumption (cups per day); CESC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg06481639 chr22:41940642 POLR3H -0.62 -6.44 -0.37 5.63e-10 Vitiligo; CESC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg11644478 chr21:40555479 PSMG1 -0.53 -6.76 -0.38 8.71e-11 Menarche (age at onset); CESC cis rs7527798 0.592 rs10746386 chr1:207855095 C/T cg21110645 chr1:207815933 NA -0.33 -5.86 -0.34 1.33e-8 Erythrocyte sedimentation rate; CESC cis rs12477438 0.605 rs4585080 chr2:99557327 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.91 -0.48 8.15e-17 Chronic sinus infection; CESC cis rs2295499 0.715 rs2282766 chr4:2658327 G/A cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.22 -0.31 3.58e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs11785400 0.793 rs3735993 chr8:143741170 G/A cg10596483 chr8:143751796 JRK 0.42 5.23 0.31 3.39e-7 Schizophrenia; CESC trans rs2155929 0.627 rs9304531 chr18:26605972 C/T cg25413575 chr17:80870577 TBCD -0.39 -6.06 -0.35 4.66e-9 Temperament (bipolar disorder); CESC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg03709012 chr19:19516395 GATAD2A 1.0 15.82 0.7 3.95e-40 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17168242 chr1:149982704 OTUD7B 0.66 7.72 0.43 2.36e-13 Gut microbiome composition (summer); CESC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.79 13.17 0.63 7.92e-31 Personality dimensions; CESC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg11764359 chr7:65958608 NA 0.8 9.99 0.52 3.86e-20 Aortic root size; CESC trans rs7839040 0.698 rs12548655 chr8:82932088 A/G cg14472086 chr9:107730925 NA -0.48 -6.45 -0.37 5.4e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs2727020 0.553 rs4980447 chr11:49591662 T/C cg03929089 chr4:120376271 NA -0.71 -8.18 -0.45 1.21e-14 Coronary artery disease; CESC cis rs9486715 0.838 rs9386576 chr6:96954717 C/T cg18709589 chr6:96969512 KIAA0776 0.46 6.48 0.37 4.41e-10 Headache; CESC cis rs10743315 0.643 rs17505214 chr12:19307139 A/G cg02471346 chr12:19282374 PLEKHA5 0.78 5.94 0.34 9.04e-9 Gut microbiota (bacterial taxa); CESC cis rs1790761 0.505 rs17593068 chr11:67350932 G/T cg14500267 chr11:67383377 NA -0.31 -5.12 -0.3 5.81e-7 Mean corpuscular volume; CESC cis rs34938134 0.686 rs7541633 chr1:245503899 C/G cg15057323 chr1:245496060 KIF26B 0.4 5.12 0.3 5.79e-7 Daytime sleep phenotypes; CESC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg03188948 chr7:1209495 NA 0.7 6.88 0.39 4.39e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17125944 0.615 rs12590862 chr14:53297008 A/G cg00686598 chr14:53173677 PSMC6 -0.69 -5.97 -0.34 7.62e-9 Alzheimer's disease (late onset); CESC cis rs4589502 1.000 rs2414925 chr15:67129986 A/G cg12317470 chr15:67143691 NA 0.67 5.62 0.33 4.71e-8 Lung cancer (smoking interaction); CESC trans rs11039798 0.623 rs7294273 chr11:48705374 T/C cg15704280 chr7:45808275 SEPT13 0.65 6.5 0.37 4.05e-10 Axial length; CESC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg17724175 chr1:150552817 MCL1 0.43 6.96 0.39 2.67e-11 Tonsillectomy; CESC cis rs116095464 0.558 rs62344345 chr5:257420 C/T cg10591111 chr5:226296 SDHA -0.51 -6.15 -0.35 2.84e-9 Breast cancer; CESC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.42 5.63 0.33 4.54e-8 Menopause (age at onset); CESC cis rs6982240 0.514 rs72681579 chr8:142263074 G/A cg00131261 chr8:142287264 NA -0.53 -7.39 -0.41 1.97e-12 Tonsillectomy; CESC cis rs782590 0.967 rs35504023 chr2:55806503 C/T cg18811423 chr2:55921094 PNPT1 -0.77 -12.36 -0.6 5.23e-28 Metabolic syndrome; CESC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg12436631 chr1:155007014 DCST1;DCST2 -0.46 -8.08 -0.44 2.37e-14 Schizophrenia; CESC cis rs10504229 0.680 rs16921675 chr8:58052082 A/G cg22535103 chr8:58192502 C8orf71 -0.63 -7.09 -0.4 1.25e-11 Developmental language disorder (linguistic errors); CESC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg07414643 chr4:187882934 NA 0.59 8.57 0.47 8.61e-16 Lobe attachment (rater-scored or self-reported); CESC trans rs11098499 0.909 rs28555550 chr4:120211040 C/G cg25214090 chr10:38739885 LOC399744 0.68 9.37 0.5 3.4e-18 Corneal astigmatism; CESC cis rs7296418 0.961 rs11613937 chr12:123520071 C/T cg00376283 chr12:123451042 ABCB9 0.77 11.23 0.57 3.44e-24 Platelet count; CESC cis rs2073300 0.609 rs3746737 chr20:23424638 C/T cg16736954 chr20:23401023 NAPB 0.73 5.23 0.31 3.38e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7524258 0.868 rs1304711 chr1:7270320 G/T cg07173049 chr1:7289937 CAMTA1 -0.39 -5.81 -0.34 1.77e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg18765753 chr7:1198926 ZFAND2A -0.41 -5.17 -0.3 4.71e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs265548 0.646 rs36689 chr19:17910639 A/G cg00024989 chr19:17902242 NA 0.44 7.52 0.42 8.31e-13 Tumor biomarkers; CESC cis rs2777491 0.874 rs7161772 chr15:41611066 A/T cg20272979 chr15:41787780 ITPKA 0.36 5.16 0.3 4.84e-7 Ulcerative colitis; CESC cis rs2243480 1.000 rs160652 chr7:65538431 A/G cg13147721 chr7:65941812 NA -1.02 -9.64 -0.51 4.9e-19 Diabetic kidney disease; CESC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg10295955 chr4:187884368 NA -1.08 -22.71 -0.81 3.93e-64 Lobe attachment (rater-scored or self-reported); CESC cis rs2439831 0.681 rs2242067 chr15:43699303 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.9 9.42 0.5 2.25e-18 Lung cancer in ever smokers; CESC cis rs2273669 0.667 rs12212402 chr6:109306681 T/C cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00810945 chr16:21964237 UQCRC2 -0.47 -6.33 -0.36 1.03e-9 Height; CESC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg16325326 chr1:53192061 ZYG11B -0.63 -9.58 -0.51 7.64e-19 Monocyte count; CESC cis rs6964587 1.000 rs2285333 chr7:91667692 T/G cg17063962 chr7:91808500 NA 0.6 8.31 0.45 4.96e-15 Breast cancer; CESC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.96 0.39 2.64e-11 Bipolar disorder; CESC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg03806693 chr22:41940476 POLR3H 1.18 13.88 0.65 2.76e-33 Vitiligo; CESC cis rs2439831 0.850 rs28413881 chr15:44174099 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.61 5.19 0.3 4.12e-7 Lung cancer in ever smokers; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23029715 chr19:42363959 RPS19 -0.45 -6.32 -0.36 1.13e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs763014 0.931 rs59476302 chr16:629006 C/T cg07256732 chr16:621771 PIGQ -0.3 -5.18 -0.3 4.3e-7 Height; CESC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.84 10.79 0.55 9.54e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25802871 chr7:2282184 FTSJ2;NUDT1 -0.47 -6.73 -0.38 1.04e-10 Gambling; CESC cis rs2204008 0.603 rs4397954 chr12:38089157 T/C cg13010199 chr12:38710504 ALG10B 0.53 6.43 0.37 5.77e-10 Bladder cancer; CESC cis rs854765 0.663 rs12941550 chr17:17753828 C/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.72 -0.38 1.1e-10 Total body bone mineral density; CESC cis rs4253772 0.614 rs11090859 chr22:46687460 T/G cg07012999 chr22:46692446 CN5H6.4;GTSE1 0.52 5.34 0.31 2.04e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2228479 0.557 rs11641726 chr16:89891619 G/A cg04013166 chr16:89971882 TCF25 0.73 5.77 0.33 2.2e-8 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22377913 chr1:26758610 DHDDS 0.64 6.89 0.39 4.13e-11 Gut microbiome composition (summer); CESC trans rs7618501 0.633 rs12496973 chr3:50002245 T/C cg21659725 chr3:3221576 CRBN 0.49 6.79 0.38 7.26e-11 Intelligence (multi-trait analysis); CESC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg02353165 chr6:42928485 GNMT 0.85 13.12 0.63 1.23e-30 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg23711669 chr6:146136114 FBXO30 -0.99 -15.07 -0.68 1.76e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs6899676 0.539 rs16870736 chr6:10878371 C/G cg03320827 chr6:10887367 SYCP2L 0.51 5.89 0.34 1.14e-8 Menopause (age at onset); CESC cis rs9660992 0.590 rs1779411 chr1:205238530 C/T cg21643547 chr1:205240462 TMCC2 -0.47 -6.34 -0.36 1.01e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs6690583 1.000 rs6690464 chr1:85466369 A/G cg22153463 chr1:85462885 MCOLN2 -0.77 -9.26 -0.49 7.39e-18 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22748698 chr17:7146447 GABARAP 0.56 6.6 0.38 2.26e-10 Gut microbiome composition (summer); CESC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg10691866 chr7:65817282 TPST1 0.31 5.22 0.31 3.55e-7 Aortic root size; CESC cis rs7582720 1.000 rs72936326 chr2:204054141 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.84 7.17 0.4 7.7e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs11252926 0.650 rs4880678 chr10:490472 G/A cg18196295 chr10:418757 DIP2C 0.41 5.54 0.32 7.31e-8 Psychosis in Alzheimer's disease; CESC cis rs8017423 0.935 rs716122 chr14:90792313 A/C cg14092571 chr14:90743983 NA 0.54 8.19 0.45 1.11e-14 Mortality in heart failure; CESC cis rs710865 1.000 rs710866 chr1:19568722 G/C cg13387374 chr1:19411106 UBR4 0.56 7.44 0.42 1.44e-12 Brain structure; CESC cis rs2227631 0.505 rs12530730 chr7:100758591 T/A cg18465962 chr7:100767262 NA 0.56 9.16 0.49 1.51e-17 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs11122272 0.766 rs1435166 chr1:231502310 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.04 -0.44 2.95e-14 Hemoglobin concentration; CESC cis rs2274273 0.870 rs1109170 chr14:55785788 A/C cg04306507 chr14:55594613 LGALS3 0.31 6.07 0.35 4.34e-9 Protein biomarker; CESC cis rs7223966 0.960 rs2319990 chr17:61705397 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.37 -0.31 1.75e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.66 0.38 1.54e-10 Bipolar disorder; CESC cis rs2303759 0.709 rs2278405 chr19:49812403 A/C cg22307029 chr19:49891270 CCDC155 -0.55 -5.96 -0.34 8.11e-9 Multiple sclerosis; CESC cis rs1215050 0.791 rs968854 chr4:98837863 T/C cg05340658 chr4:99064831 C4orf37 0.5 6.44 0.37 5.57e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg22633769 chr20:60982531 CABLES2 0.52 5.52 0.32 8.23e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs12136530 0.593 rs10917443 chr1:19724079 A/C cg01832549 chr1:19774989 CAPZB -0.43 -6.21 -0.36 2.09e-9 Lead levels in blood; CESC cis rs2732480 0.500 rs7297824 chr12:48598650 T/C cg24011408 chr12:48396354 COL2A1 0.43 6.11 0.35 3.5e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs4688759 0.719 rs73079018 chr3:49875327 T/C cg00383909 chr3:49044727 WDR6 0.85 5.49 0.32 9.46e-8 Blood protein levels; CESC cis rs67460515 0.892 rs6780536 chr3:161058726 T/C cg03342759 chr3:160939853 NMD3 -0.54 -7.86 -0.43 9.59e-14 Parkinson's disease; CESC cis rs5769707 0.967 rs17182154 chr22:49990470 A/G cg05373962 chr22:49881684 NA -0.36 -6.18 -0.35 2.44e-9 Monocyte count;Monocyte percentage of white cells; CESC cis rs6426558 0.537 rs6682642 chr1:227244600 G/T cg10327440 chr1:227177885 CDC42BPA 0.45 5.78 0.33 2.08e-8 Neutrophil percentage of white cells; CESC cis rs10927875 0.562 rs10803401 chr1:16147377 G/A cg21385522 chr1:16154831 NA -1.02 -16.41 -0.71 2.97e-42 Dilated cardiomyopathy; CESC cis rs863345 1.000 rs863353 chr1:158541270 C/A cg12129480 chr1:158549410 OR10X1 -0.32 -6.46 -0.37 5.08e-10 Pneumococcal bacteremia; CESC trans rs875971 0.638 rs10249404 chr7:66046724 G/A cg26939375 chr7:64535504 NA -0.63 -8.52 -0.46 1.25e-15 Aortic root size; CESC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg22143856 chr6:28129313 ZNF389 0.52 6.77 0.38 8.31e-11 Parkinson's disease; CESC cis rs4629710 0.645 rs35561719 chr6:131551244 G/A cg12606694 chr6:131520996 AKAP7 0.48 5.92 0.34 9.77e-9 Multiple myeloma (IgH translocation); CESC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg18240062 chr17:79603768 NPLOC4 0.72 10.27 0.53 4.71e-21 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07160044 chr13:24735301 SPATA13;MIR2276 0.61 7.26 0.41 4.22e-12 Gut microbiome composition (summer); CESC cis rs478304 0.651 rs11227279 chr11:65495211 G/A cg10518572 chr11:65560635 OVOL1 -0.32 -6.19 -0.36 2.31e-9 Acne (severe); CESC cis rs9303401 0.659 rs12602389 chr17:56779778 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC trans rs875971 0.895 rs778700 chr7:65866450 C/T cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.77e-9 Aortic root size; CESC trans rs11098499 0.779 rs10016060 chr4:120298412 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg18876405 chr7:65276391 NA -0.54 -7.41 -0.41 1.7e-12 Aortic root size; CESC cis rs6459804 0.844 rs76501205 chr7:157508941 A/T cg05731713 chr7:157510257 PTPRN2 0.4 6.55 0.37 2.93e-10 Bipolar disorder and schizophrenia; CESC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.22 -0.36 1.98e-9 Total body bone mineral density; CESC cis rs938554 0.736 rs11734219 chr4:9977154 C/T cg00071950 chr4:10020882 SLC2A9 0.48 5.68 0.33 3.49e-8 Blood metabolite levels; CESC cis rs3733585 0.726 rs4306953 chr4:9955776 G/A cg00071950 chr4:10020882 SLC2A9 -0.69 -11.31 -0.57 1.83e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs941408 1.000 rs1736180 chr19:2796021 C/T cg06609049 chr19:2785107 THOP1 0.74 10.87 0.56 5.35e-23 Total cholesterol levels; CESC cis rs1865721 1.000 rs72977890 chr18:73198776 C/A cg26385618 chr18:73139727 C18orf62 -0.52 -7.73 -0.43 2.26e-13 Intelligence; CESC cis rs6570726 0.935 rs390252 chr6:145856896 A/G cg05347473 chr6:146136440 FBXO30 0.48 6.44 0.37 5.7e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9303401 0.659 rs34878689 chr17:56694330 G/A cg02118635 chr17:56770003 RAD51C;TEX14 1.0 11.58 0.58 2.27e-25 Cognitive test performance; CESC cis rs1879734 0.773 rs7518284 chr1:54150890 A/T cg23596471 chr1:54105337 GLIS1 0.33 5.24 0.31 3.27e-7 Mitral valve prolapse; CESC cis rs3733585 0.699 rs10017674 chr4:9967053 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.58 -0.32 5.96e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1865760 0.566 rs9358904 chr6:26068566 C/T cg16482183 chr6:26056742 HIST1H1C 0.4 5.4 0.31 1.49e-7 Height; CESC cis rs12971120 0.891 rs4891558 chr18:72170359 A/G cg26446133 chr18:72167187 CNDP2 -0.76 -9.29 -0.5 6.04e-18 Refractive error; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg16830545 chr17:17120324 FLCN -0.45 -6.03 -0.35 5.46e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs13082711 0.863 rs77135084 chr3:27423549 A/C cg02860705 chr3:27208620 NA 0.58 7.2 0.4 6.4e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09015484 chr9:96929106 NA 0.46 6.4 0.37 7.15e-10 Systemic lupus erythematosus; CESC cis rs9487051 0.639 rs2884012 chr6:109598221 C/T cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs6951245 0.572 rs73264028 chr7:1045455 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.61 -5.44 -0.32 1.23e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 0.534 rs1130033 chr6:167385623 C/T cg25258033 chr6:167368657 RNASET2 0.37 5.14 0.3 5.31e-7 Crohn's disease; CESC cis rs3820068 0.581 rs72645864 chr1:15921153 C/T cg16988262 chr1:15930761 NA 0.35 5.63 0.33 4.6e-8 Systolic blood pressure; CESC cis rs523522 1.000 rs1563333 chr12:120934407 C/T cg27279351 chr12:120934652 DYNLL1 0.69 8.94 0.48 6.79e-17 High light scatter reticulocyte count; CESC cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg26116260 chr4:7069785 GRPEL1 0.96 13.91 0.65 2.11e-33 Monocyte percentage of white cells; CESC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -7.05 -0.4 1.58e-11 Bipolar disorder and schizophrenia; CESC cis rs4268898 0.552 rs12621083 chr2:24367540 C/T cg06627628 chr2:24431161 ITSN2 0.59 8.19 0.45 1.12e-14 Asthma; CESC cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 1.000 rs11079365 chr17:56945430 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.96 -0.39 2.6e-11 Intelligence (multi-trait analysis); CESC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg07157834 chr1:205819609 PM20D1 0.73 10.38 0.54 2.17e-21 Menarche (age at onset); CESC cis rs4604732 0.527 rs12031949 chr1:247624463 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.58 7.26 0.41 4.23e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9660992 0.624 rs72745217 chr1:205261482 C/G cg21643547 chr1:205240462 TMCC2 -0.47 -6.25 -0.36 1.6e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs3820068 0.581 rs59991988 chr1:15950552 T/A cg16988262 chr1:15930761 NA 0.34 5.47 0.32 1.04e-7 Systolic blood pressure; CESC cis rs561341 1.000 rs8077092 chr17:30281992 T/C cg19193384 chr17:30244184 NA -0.62 -6.45 -0.37 5.21e-10 Hip circumference adjusted for BMI; CESC cis rs4481887 0.861 rs6681336 chr1:248482756 C/T cg00666640 chr1:248458726 OR2T12 0.34 5.64 0.33 4.3e-8 Common traits (Other); CESC cis rs6496932 0.563 rs2344083 chr15:85897432 T/C cg19183879 chr15:85880815 NA -0.34 -6.16 -0.35 2.76e-9 Central corneal thickness;Corneal structure; CESC cis rs2742234 0.910 rs2505513 chr10:43633537 C/G cg07801480 chr10:43725741 RASGEF1A 0.39 5.64 0.33 4.27e-8 Hirschsprung disease; CESC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg14664628 chr15:75095509 CSK -0.53 -6.93 -0.39 3.29e-11 Breast cancer; CESC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg18876405 chr7:65276391 NA 0.44 6.08 0.35 4.21e-9 Aortic root size; CESC cis rs4808199 0.948 rs8108647 chr19:19427623 A/G cg03709012 chr19:19516395 GATAD2A 1.08 11.69 0.58 9.9e-26 Nonalcoholic fatty liver disease; CESC cis rs6460942 1.000 rs75333414 chr7:12303829 T/A cg02935154 chr7:12443704 VWDE -0.52 -5.52 -0.32 8.01e-8 Coronary artery disease; CESC cis rs9291683 0.935 rs1860910 chr4:10275470 T/G cg11266682 chr4:10021025 SLC2A9 0.47 8.4 0.46 2.71e-15 Bone mineral density; CESC cis rs524281 0.731 rs6591203 chr11:65806229 G/A cg14036092 chr11:66035641 RAB1B 0.5 5.08 0.3 7.08e-7 Electroencephalogram traits; CESC cis rs2073300 0.609 rs17757442 chr20:23421101 A/G cg12062639 chr20:23401060 NAPB -1.06 -8.8 -0.48 1.81e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.47 0.46 1.69e-15 Bipolar disorder; CESC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg03452623 chr4:187889614 NA -0.88 -16.39 -0.71 3.66e-42 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00804338 chr13:114239234 TFDP1 -0.4 -6.09 -0.35 4.05e-9 Fibrinogen levels; CESC cis rs11711311 0.955 rs9881563 chr3:113414031 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.65 -8.83 -0.48 1.45e-16 IgG glycosylation; CESC trans rs7246657 0.882 rs4803539 chr19:37897522 A/C cg24637308 chr11:6592297 DNHD1 0.54 6.3 0.36 1.21e-9 Coronary artery calcification; CESC cis rs35306767 0.714 rs7075188 chr10:1088746 G/T cg26597838 chr10:835615 NA -0.48 -5.28 -0.31 2.74e-7 Eosinophil percentage of granulocytes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14898140 chr17:66031871 KPNA2 -0.48 -6.62 -0.38 1.99e-10 Fibrinogen levels; CESC cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg14440974 chr22:39074834 NA 0.41 5.43 0.32 1.27e-7 Menopause (age at onset); CESC cis rs9287719 0.967 rs6759740 chr2:10747271 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18313530 chr11:111749763 C11orf1;FDXACB1 0.6 6.99 0.39 2.26e-11 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg04944784 chr2:26401820 FAM59B -0.96 -10.55 -0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs8044868 0.586 rs8182213 chr16:72080005 C/T cg16558253 chr16:72132732 DHX38 -0.4 -6.32 -0.36 1.12e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs4642101 0.765 rs9871991 chr3:12827525 C/A cg05775895 chr3:12838266 CAND2 0.38 5.69 0.33 3.31e-8 QRS complex (12-leadsum); CESC trans rs11098499 0.863 rs1552095 chr4:120460306 A/G cg25214090 chr10:38739885 LOC399744 0.69 9.12 0.49 2e-17 Corneal astigmatism; CESC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg07092213 chr7:1199455 ZFAND2A -0.49 -5.17 -0.3 4.65e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs533581 0.844 rs548591 chr16:88974516 A/G cg16701003 chr16:89028210 CBFA2T3 0.55 8.27 0.45 6.73e-15 Social autistic-like traits; CESC cis rs9908102 0.710 rs41494747 chr17:12914920 A/G cg26162695 chr17:12921313 ELAC2 0.52 6.0 0.35 6.29e-9 Schizophrenia; CESC trans rs875971 1.000 rs2077593 chr7:65892530 A/G cg26939375 chr7:64535504 NA 0.47 6.05 0.35 4.96e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21167072 chr6:90539455 CASP8AP2 -0.56 -6.29 -0.36 1.34e-9 Gut microbiome composition (summer); CESC cis rs7605827 0.930 rs6753645 chr2:15539556 G/C cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs3780486 0.846 rs10124479 chr9:33136233 T/G cg13443165 chr9:33130375 B4GALT1 0.46 6.78 0.38 7.98e-11 IgG glycosylation; CESC cis rs2228479 0.850 rs1108063 chr16:89893983 A/G cg14709524 chr16:89940631 TCF25 0.89 6.42 0.37 6.21e-10 Skin colour saturation; CESC cis rs9894429 0.869 rs9748184 chr17:79596280 A/G cg21984481 chr17:79567631 NPLOC4 -0.49 -7.86 -0.43 9.77e-14 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05534213 chr10:43932466 ZNF487 0.55 6.23 0.36 1.83e-9 Gut microbiome composition (summer); CESC cis rs9527 0.622 rs12779263 chr10:104886533 G/T cg04362960 chr10:104952993 NT5C2 0.46 5.54 0.32 7.43e-8 Arsenic metabolism; CESC cis rs12541635 0.677 rs2163124 chr8:107058862 G/T cg10147462 chr8:107024639 NA 0.48 7.19 0.4 6.78e-12 Age of smoking initiation; CESC cis rs6502050 0.736 rs12150322 chr17:80061582 T/G cg11859384 chr17:80120422 CCDC57 0.38 5.1 0.3 6.51e-7 Life satisfaction; CESC cis rs962856 0.575 rs661435 chr2:67654113 A/G cg09028215 chr2:67624308 ETAA1 0.46 5.59 0.32 5.67e-8 Pancreatic cancer; CESC cis rs2243480 0.764 rs2460423 chr7:65601216 A/T cg18252515 chr7:66147081 NA -1.41 -14.46 -0.66 2.54e-35 Diabetic kidney disease; CESC trans rs12310956 0.532 rs7967627 chr12:33974669 G/T cg26384229 chr12:38710491 ALG10B 0.51 6.98 0.39 2.42e-11 Morning vs. evening chronotype; CESC cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs6812193 0.518 rs28597785 chr4:77188288 G/C cg20311846 chr4:77356250 SHROOM3 0.28 5.14 0.3 5.41e-7 Parkinson's disease; CESC cis rs35110281 0.782 rs9981790 chr21:45045052 G/C cg04455712 chr21:45112962 RRP1B 0.42 6.36 0.36 8.8e-10 Mean corpuscular volume; CESC cis rs6496667 0.510 rs16944405 chr15:90975517 A/G cg22089800 chr15:90895588 ZNF774 0.5 6.36 0.36 8.64e-10 Rheumatoid arthritis; CESC cis rs7605827 0.930 rs4133515 chr2:15696655 A/G cg19274914 chr2:15703543 NA 0.37 6.48 0.37 4.42e-10 Educational attainment (years of education); CESC cis rs763121 0.815 rs12168758 chr22:38997269 C/G cg06022373 chr22:39101656 GTPBP1 0.8 12.95 0.62 4.88e-30 Menopause (age at onset); CESC cis rs4713675 0.565 rs4713659 chr6:33667839 A/G cg14003231 chr6:33640908 ITPR3 0.34 6.04 0.35 5.08e-9 Plateletcrit; CESC cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg05347473 chr6:146136440 FBXO30 0.75 9.51 0.5 1.19e-18 Lobe attachment (rater-scored or self-reported); CESC cis rs4925325 0.876 rs6089560 chr20:60517325 T/G cg13770153 chr20:60521292 NA -0.84 -12.35 -0.6 5.54e-28 Obesity-related traits; CESC cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg08564027 chr20:61660810 NA 0.9 15.37 0.69 1.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs7937682 0.883 rs512669 chr11:111467893 G/A cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC cis rs208520 0.690 rs12201156 chr6:66720874 G/T cg07460842 chr6:66804631 NA 0.94 12.59 0.61 8.06e-29 Exhaled nitric oxide output; CESC cis rs11098499 0.866 rs9991221 chr4:120292107 G/C cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs763121 0.819 rs4560233 chr22:38982442 A/T cg14440974 chr22:39074834 NA -0.39 -5.24 -0.31 3.33e-7 Menopause (age at onset); CESC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.38 0.31 1.66e-7 Personality dimensions; CESC cis rs72901758 0.768 rs55782477 chr17:76250703 G/C cg26068271 chr17:76253126 NA 0.46 6.6 0.38 2.25e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs524023 0.914 rs11606370 chr11:64378452 C/A cg07220939 chr11:64358617 SLC22A12 -0.35 -5.35 -0.31 1.94e-7 Urate levels in obese individuals; CESC cis rs28374715 0.733 rs9568 chr15:41573612 G/T cg18705301 chr15:41695430 NDUFAF1 -0.89 -12.61 -0.61 7.18e-29 Ulcerative colitis; CESC cis rs2629540 0.765 rs11245387 chr10:126537825 C/T cg08799069 chr10:126477246 METTL10 -0.53 -7.49 -0.42 1.04e-12 Cocaine dependence; CESC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg21963583 chr11:68658836 MRPL21 0.39 5.75 0.33 2.47e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1577917 1.000 rs6936048 chr6:86702608 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.79 -0.33 2.02e-8 Response to antipsychotic treatment; CESC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.53 3.63e-21 Prudent dietary pattern; CESC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.67 0.38 1.45e-10 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25752797 chr13:25670228 PABPC3 -0.52 -7.08 -0.4 1.3e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.753 rs13122897 chr4:98936185 C/A cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2835872 0.758 rs1709820 chr21:39035971 A/C cg06728970 chr21:39037746 KCNJ6 0.3 5.58 0.32 5.99e-8 Electroencephalographic traits in alcoholism; CESC cis rs9527 0.571 rs7096249 chr10:104618524 G/A cg04362960 chr10:104952993 NT5C2 0.47 6.04 0.35 5.12e-9 Arsenic metabolism; CESC cis rs2425143 1.000 rs733609 chr20:34393074 A/T cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.93 0.34 9.19e-9 Blood protein levels; CESC trans rs1814175 0.645 rs6486022 chr11:49776137 A/G cg15704280 chr7:45808275 SEPT13 -0.99 -17.45 -0.73 6.41e-46 Height; CESC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg02569458 chr12:86230093 RASSF9 0.48 7.23 0.41 5.05e-12 Major depressive disorder; CESC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg22307029 chr19:49891270 CCDC155 0.71 8.2 0.45 1.06e-14 Multiple sclerosis; CESC cis rs11785400 0.762 rs7007349 chr8:143722673 T/C cg10596483 chr8:143751796 JRK 0.42 5.35 0.31 1.86e-7 Schizophrenia; CESC cis rs7208859 0.562 rs216408 chr17:28907757 C/G cg04154034 chr17:28927549 LRRC37B2 -0.7 -6.45 -0.37 5.3e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12614633 chr1:22110289 USP48 -0.48 -6.72 -0.38 1.12e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs832540 1.000 rs252913 chr5:56195846 C/T cg14703610 chr5:56206110 C5orf35 -0.52 -7.03 -0.4 1.75e-11 Coronary artery disease; CESC cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.47 0.46 1.72e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg15674680 chr20:60982522 CABLES2 -0.48 -6.07 -0.35 4.5e-9 Colorectal cancer; CESC cis rs6963495 0.818 rs818621 chr7:105173029 T/C cg19920283 chr7:105172520 RINT1 0.72 7.94 0.44 5.6e-14 Bipolar disorder (body mass index interaction); CESC cis rs12545109 0.800 rs2609979 chr8:57390066 G/A cg09654669 chr8:57350985 NA -0.57 -7.21 -0.41 5.71e-12 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12672205 chr22:39101803 GTPBP1 0.56 6.25 0.36 1.59e-9 Gut microbiome composition (summer); CESC cis rs10876993 0.855 rs10877007 chr12:58100058 T/A cg18357645 chr12:58087776 OS9 0.63 10.47 0.54 1.11e-21 Celiac disease or Rheumatoid arthritis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05508478 chr11:9482677 ZNF143 0.45 6.03 0.35 5.49e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6569992 0.636 rs55683605 chr6:135487107 C/T cg22676075 chr6:135203613 NA 0.56 5.45 0.32 1.14e-7 Red blood cell traits; CESC cis rs11792861 0.926 rs77567374 chr9:111835034 T/C cg05043794 chr9:111880884 C9orf5 -0.4 -6.51 -0.37 3.67e-10 Menarche (age at onset); CESC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.68 0.33 3.49e-8 Menopause (age at onset); CESC cis rs7703051 0.760 rs34341 chr5:74934009 A/T cg03227963 chr5:74354835 NA -0.28 -5.11 -0.3 6.15e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg20151795 chr6:28129481 ZNF389 0.35 5.06 0.3 7.95e-7 Cardiac Troponin-T levels; CESC cis rs7917772 0.546 rs10883743 chr10:104338389 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.61 0.33 5.05e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg27266027 chr21:40555129 PSMG1 0.46 5.59 0.32 5.69e-8 Cognitive function; CESC cis rs5769765 0.954 rs5769762 chr22:50264042 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16207528 chr7:48964051 CDC14C -0.62 -7.62 -0.42 4.59e-13 Gut microbiome composition (summer); CESC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg06494592 chr3:125709126 NA -0.5 -5.66 -0.33 3.89e-8 Blood pressure (smoking interaction); CESC cis rs1707322 1.000 rs1768801 chr1:46549137 C/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.57 -0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1808579 0.874 rs1788817 chr18:21097460 A/G cg14672496 chr18:21087552 C18orf8 0.45 6.48 0.37 4.35e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs651907 0.557 rs11917569 chr3:101355063 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 5.84 0.34 1.56e-8 Colorectal cancer; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20203792 chr4:20701925 PACRGL -0.46 -6.23 -0.36 1.87e-9 Height; CESC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg20203395 chr5:56204925 C5orf35 0.51 5.83 0.34 1.6e-8 Initial pursuit acceleration; CESC cis rs9487051 0.676 rs9400267 chr6:109600164 T/C cg12927641 chr6:109611667 NA -0.36 -5.28 -0.31 2.66e-7 Reticulocyte fraction of red cells; CESC cis rs6500395 0.962 rs9937568 chr16:48612361 C/T cg04672837 chr16:48644449 N4BP1 -0.44 -5.34 -0.31 2.04e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7927771 0.524 rs12785949 chr11:47729770 C/T cg20307385 chr11:47447363 PSMC3 0.62 8.6 0.47 7.23e-16 Subjective well-being; CESC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 8.88 0.48 1.02e-16 Platelet count; CESC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg13393036 chr8:95962371 TP53INP1 -0.54 -11.91 -0.59 1.74e-26 Type 2 diabetes; CESC cis rs10242455 0.702 rs73405247 chr7:99159174 C/G cg18809830 chr7:99032528 PTCD1 -0.66 -5.21 -0.3 3.84e-7 Blood metabolite levels; CESC cis rs9583531 0.600 rs7330080 chr13:111367115 C/T cg15841412 chr13:111365552 ING1 0.47 6.27 0.36 1.48e-9 Coronary artery disease; CESC cis rs6582630 0.555 rs4601853 chr12:38435569 G/A cg26384229 chr12:38710491 ALG10B 0.69 10.57 0.54 5e-22 Drug-induced liver injury (flucloxacillin); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00822591 chr3:16306489 DPH3;OXNAD1 -0.52 -6.98 -0.39 2.38e-11 Fibrinogen levels; CESC cis rs868036 0.609 rs28742003 chr15:68127769 C/T cg24579218 chr15:68104479 NA -0.39 -5.47 -0.32 1.05e-7 Restless legs syndrome; CESC cis rs4242434 0.747 rs6986550 chr8:22467870 T/A cg03733263 chr8:22462867 KIAA1967 0.88 14.76 0.67 2.2e-36 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs3892630 0.588 rs7248798 chr19:33303684 G/T cg22980127 chr19:33182716 NUDT19 1.15 15.15 0.68 8.77e-38 Red blood cell traits; CESC cis rs2282802 0.660 rs7726176 chr5:139547971 T/A cg26211634 chr5:139558579 C5orf32 -0.46 -6.65 -0.38 1.65e-10 Intelligence (multi-trait analysis); CESC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg18230493 chr5:56204884 C5orf35 -0.7 -8.55 -0.47 9.85e-16 Initial pursuit acceleration; CESC cis rs12681288 0.676 rs17740799 chr8:1014327 C/T cg04851639 chr8:1020857 NA 0.35 7.54 0.42 7.43e-13 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10705503 chr12:102513685 C12orf48;NUP37 -0.4 -6.15 -0.35 2.89e-9 Gambling; CESC cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg09796270 chr17:17721594 SREBF1 -0.38 -5.1 -0.3 6.41e-7 Total body bone mineral density; CESC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg19901468 chr14:105411992 AHNAK2 -0.6 -8.68 -0.47 4.07e-16 Rheumatoid arthritis; CESC cis rs4268898 0.552 rs11125444 chr2:24367205 G/T cg06627628 chr2:24431161 ITSN2 0.59 8.19 0.45 1.12e-14 Asthma; CESC cis rs3020736 0.500 rs4147638 chr22:42487900 G/A cg04733989 chr22:42467013 NAGA -0.83 -12.68 -0.61 3.98e-29 Autism spectrum disorder or schizophrenia; CESC cis rs2180341 1.000 rs6910763 chr6:127630925 T/C cg27446573 chr6:127587934 RNF146 1.09 16.33 0.71 5.73e-42 Breast cancer; CESC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 9.57 0.51 8.02e-19 Alzheimer's disease; CESC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg19163074 chr7:65112434 INTS4L2 0.43 5.49 0.32 9.47e-8 Aortic root size; CESC cis rs2859741 0.546 rs2133910 chr1:37478785 G/T cg09363841 chr1:37513479 NA -0.49 -7.17 -0.4 7.42e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22335246 chr12:120763591 PLA2G1B 0.49 6.92 0.39 3.49e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2933343 1.000 rs1683776 chr3:128622760 G/T cg25356066 chr3:128598488 ACAD9 0.59 7.16 0.4 7.76e-12 IgG glycosylation; CESC trans rs4332037 0.851 rs34040190 chr7:1920356 G/A cg11693508 chr17:37793320 STARD3 0.68 6.43 0.37 5.94e-10 Bipolar disorder; CESC cis rs6831352 0.918 rs17817958 chr4:100061245 A/C cg12011299 chr4:100065546 ADH4 0.53 5.62 0.33 4.89e-8 Alcohol dependence; CESC cis rs2404602 0.692 rs35138393 chr15:76977617 G/A cg22467129 chr15:76604101 ETFA -0.34 -5.15 -0.3 5.13e-7 Blood metabolite levels; CESC cis rs2290159 0.898 rs2290160 chr3:12633083 A/G cg23032965 chr3:12705835 RAF1 0.49 5.48 0.32 9.8e-8 Cholesterol, total; CESC cis rs3829251 0.786 rs7103591 chr11:71237619 T/C cg05163923 chr11:71159392 DHCR7 -0.54 -5.61 -0.33 5.1e-8 Vitamin D levels; CESC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg24060327 chr5:131705240 SLC22A5 -0.49 -6.26 -0.36 1.56e-9 Acylcarnitine levels; CESC cis rs11122272 0.701 rs2486725 chr1:231540288 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.47 -0.42 1.14e-12 Hemoglobin concentration; CESC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg25985355 chr7:65971099 NA 0.32 5.38 0.31 1.63e-7 Aortic root size; CESC cis rs6582630 0.598 rs10880614 chr12:38509766 G/A cg26384229 chr12:38710491 ALG10B -0.41 -5.44 -0.32 1.23e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs735396 0.595 rs1169279 chr12:121455873 C/T cg15155738 chr12:121454335 C12orf43 0.45 5.24 0.31 3.31e-7 N-glycan levels; CESC cis rs7208859 0.623 rs9915566 chr17:29132158 G/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2228479 0.717 rs17233678 chr16:89809962 T/C cg19635926 chr16:89946313 TCF25 0.66 5.04 0.3 8.52e-7 Skin colour saturation; CESC cis rs9868809 0.542 rs9873726 chr3:48712367 C/T cg07636037 chr3:49044803 WDR6 -0.61 -5.53 -0.32 7.82e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.87 0.34 1.3e-8 Hip circumference adjusted for BMI; CESC cis rs9948 0.655 rs78424221 chr2:97410399 A/G cg01990225 chr2:97406019 LMAN2L -0.98 -7.35 -0.41 2.39e-12 Erectile dysfunction and prostate cancer treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00482020 chr16:25026850 ARHGAP17 0.58 7.09 0.4 1.25e-11 Gut microbiome composition (summer); CESC cis rs9858542 0.953 rs34588335 chr3:49407660 G/C cg07274523 chr3:49395745 GPX1 0.68 8.49 0.46 1.55e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs1493916 0.905 rs4799727 chr18:31393095 T/G cg27147174 chr7:100797783 AP1S1 -0.52 -6.92 -0.39 3.32e-11 Life satisfaction; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07473634 chr13:113647389 MCF2L -0.38 -6.06 -0.35 4.62e-9 Gut microbiota (bacterial taxa); CESC trans rs12310956 0.515 rs11052934 chr12:33970381 T/C cg26384229 chr12:38710491 ALG10B 0.45 6.21 0.36 1.99e-9 Morning vs. evening chronotype; CESC cis rs3749237 0.615 rs6792911 chr3:49429856 C/T cg03060546 chr3:49711283 APEH 0.75 11.32 0.57 1.71e-24 Resting heart rate; CESC cis rs9325144 0.671 rs7486919 chr12:38767997 A/G cg26384229 chr12:38710491 ALG10B -0.56 -7.9 -0.44 7.48e-14 Morning vs. evening chronotype; CESC cis rs9467711 0.659 rs34605993 chr6:26454363 C/T cg14345882 chr6:26364793 BTN3A2 0.67 5.41 0.32 1.42e-7 Autism spectrum disorder or schizophrenia; CESC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg01341218 chr17:43662625 NA -0.86 -10.99 -0.56 2.19e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2749592 0.550 rs9733309 chr10:37882405 G/A cg25427524 chr10:38739819 LOC399744 0.55 7.65 0.43 3.64e-13 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs854765 0.565 rs4072738 chr17:17884547 A/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.69 0.38 1.3100000000000001e-10 Total body bone mineral density; CESC cis rs7714584 1.000 rs76548544 chr5:150223515 T/A cg22134413 chr5:150180641 NA 0.53 5.75 0.33 2.47e-8 Crohn's disease; CESC cis rs10203711 0.966 rs4998692 chr2:239564772 T/G cg14580085 chr2:239553406 NA 0.34 5.16 0.3 4.74e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs77741769 0.571 rs34009825 chr12:121326183 A/G cg02419362 chr12:121203948 SPPL3 0.34 5.58 0.32 5.97e-8 Mean corpuscular volume; CESC cis rs2304069 0.779 rs245080 chr5:149354805 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.71 -9.1 -0.49 2.23e-17 HIV-1 control; CESC trans rs1814175 0.645 rs847632 chr11:49926097 C/T cg03929089 chr4:120376271 NA -0.89 -14.83 -0.67 1.17e-36 Height; CESC cis rs9894429 0.646 rs12948797 chr17:79617384 G/A cg18240062 chr17:79603768 NPLOC4 0.48 6.12 0.35 3.28e-9 Eye color traits; CESC cis rs9399401 0.626 rs4304190 chr6:142778912 A/G cg03128060 chr6:142623767 GPR126 0.3 5.03 0.3 8.92e-7 Chronic obstructive pulmonary disease; CESC cis rs10927875 0.894 rs10927878 chr1:16319957 C/T cg21214613 chr1:16344536 HSPB7 -0.38 -5.78 -0.33 2.1e-8 Dilated cardiomyopathy; CESC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg13206674 chr6:150067644 NUP43 0.38 5.12 0.3 5.87e-7 Lung cancer; CESC cis rs35306767 0.714 rs10508206 chr10:1075777 A/C cg20503657 chr10:835505 NA 0.5 5.13 0.3 5.68e-7 Eosinophil percentage of granulocytes; CESC cis rs35146811 0.586 rs10267231 chr7:99595480 T/C cg14163444 chr7:99595348 NA -0.39 -5.11 -0.3 6.28e-7 Coronary artery disease; CESC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg05890377 chr2:74357713 NA 0.78 9.11 0.49 2.07e-17 Gestational age at birth (maternal effect); CESC cis rs2439831 0.850 rs3736180 chr15:44106624 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.66 5.97 0.34 7.58e-9 Lung cancer in ever smokers; CESC cis rs116095464 0.558 rs6878061 chr5:223072 A/G cg22496380 chr5:211416 CCDC127 -0.72 -8.57 -0.47 8.59e-16 Breast cancer; CESC cis rs9916302 0.645 rs1053651 chr17:37822311 A/C cg00129232 chr17:37814104 STARD3 -0.75 -10.23 -0.53 6.33e-21 Glomerular filtration rate (creatinine); CESC cis rs12142240 0.698 rs77185326 chr1:46818417 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs7020830 0.867 rs1339553 chr9:37266123 C/G cg14294708 chr9:37120828 ZCCHC7 1.21 22.97 0.82 5.23e-65 Schizophrenia; CESC cis rs9916302 0.706 rs7503377 chr17:37708841 A/G cg07936489 chr17:37558343 FBXL20 -0.98 -10.93 -0.56 3.28e-23 Glomerular filtration rate (creatinine); CESC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg00934597 chr7:893267 UNC84A -0.53 -7.19 -0.4 6.66e-12 Perceived unattractiveness to mosquitoes; CESC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg12311346 chr5:56204834 C5orf35 0.65 8.47 0.46 1.68e-15 Initial pursuit acceleration; CESC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg12288994 chr5:1860383 NA 0.42 7.0 0.4 2.04e-11 Cardiovascular disease risk factors; CESC cis rs7917772 0.503 rs11191330 chr10:104306160 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.56 7.87 0.44 9.28e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs4604732 0.631 rs12039596 chr1:247624766 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg06212747 chr3:49208901 KLHDC8B 0.68 8.98 0.48 5.01e-17 Parkinson's disease; CESC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg11941060 chr3:133502564 NA -0.48 -6.64 -0.38 1.79e-10 Iron status biomarkers; CESC cis rs7312933 0.531 rs2406674 chr12:42720150 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.4 -0.37 7.09e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs11864453 0.713 rs2241412 chr16:72144284 A/G cg01557791 chr16:72042693 DHODH -0.48 -6.35 -0.36 9.29e-10 Fibrinogen levels; CESC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg27588902 chr6:42928151 GNMT 0.29 5.52 0.32 8.05e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs3947 0.906 rs709822 chr8:11702313 C/G cg00262122 chr8:11665843 FDFT1 -0.48 -5.36 -0.31 1.82e-7 Blood protein levels; CESC cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg10523679 chr1:76189770 ACADM 0.73 8.74 0.47 2.81e-16 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg22535103 chr8:58192502 C8orf71 -1.04 -12.83 -0.62 1.26e-29 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19329146 chr7:30544921 GGCT 0.66 7.35 0.41 2.47e-12 Gut microbiome composition (summer); CESC cis rs34779708 0.897 rs4934716 chr10:35369299 A/G cg04310649 chr10:35416472 CREM -0.52 -6.4 -0.37 7.03e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs1950626 0.751 rs12883799 chr14:101396850 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.8 10.73 0.55 1.57e-22 Pelvic organ prolapse (moderate/severe); CESC cis rs644799 0.622 rs1255167 chr11:95500213 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.64 8.59 0.47 7.64e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6694270 0.529 rs4076925 chr1:19113026 C/T cg19637330 chr1:19110922 NA 0.55 7.02 0.4 1.91e-11 Drug-induced liver injury (nitrofurantoin); CESC cis rs6545883 0.965 rs9989775 chr2:61761774 A/G cg15711740 chr2:61764176 XPO1 -0.44 -5.37 -0.31 1.73e-7 Tuberculosis; CESC cis rs6426558 0.514 rs3754418 chr1:227348473 T/C cg10327440 chr1:227177885 CDC42BPA -0.46 -5.72 -0.33 2.86e-8 Neutrophil percentage of white cells; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg18044720 chr4:87857031 AFF1 -0.43 -6.05 -0.35 4.9e-9 Vertical cup-disc ratio; CESC cis rs2180341 1.000 rs2038378 chr6:127590400 C/T cg24812749 chr6:127587940 RNF146 1.06 15.28 0.68 3.03e-38 Breast cancer; CESC cis rs2075671 0.810 rs12531792 chr7:100280624 G/A cg16850897 chr7:100343110 ZAN -0.7 -8.9 -0.48 9.03e-17 Other erythrocyte phenotypes; CESC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg02018176 chr4:1364513 KIAA1530 0.5 7.0 0.39 2.14e-11 Longevity; CESC cis rs2730245 0.636 rs2657382 chr7:158650941 G/A cg01943577 chr7:158741284 NA -0.41 -5.25 -0.31 3.07e-7 Height; CESC cis rs9911578 1.000 rs12936058 chr17:57017420 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.14 0.3 5.41e-7 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08039701 chr5:74063125 NSA2;GFM2 -0.36 -6.08 -0.35 4.25e-9 Gambling; CESC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg02564969 chr6:151773285 C6orf211;RMND1 0.61 8.46 0.46 1.89e-15 Menarche (age at onset); CESC cis rs1153858 1.000 rs10519022 chr15:45663684 C/T cg21132104 chr15:45694354 SPATA5L1 -0.86 -11.63 -0.58 1.6e-25 Homoarginine levels; CESC cis rs9902453 0.765 rs8079209 chr17:28186773 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 8.77 0.47 2.28e-16 Coffee consumption (cups per day); CESC cis rs7818345 1.000 rs12675717 chr8:19293177 G/A cg11303988 chr8:19266685 CSGALNACT1 0.35 6.31 0.36 1.17e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs7824557 0.583 rs2736306 chr8:11239762 A/T cg21775007 chr8:11205619 TDH 0.5 7.52 0.42 8.43e-13 Retinal vascular caliber; CESC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.59 -0.32 5.57e-8 Aortic root size; CESC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg22535103 chr8:58192502 C8orf71 -0.96 -9.81 -0.52 1.45e-19 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15464645 chr15:28380110 HERC2 -0.61 -6.63 -0.38 1.85e-10 Gut microbiome composition (summer); CESC cis rs244293 0.831 rs11079149 chr17:53095046 A/G cg19360675 chr17:53046073 COX11;STXBP4 0.4 5.11 0.3 6.18e-7 Menarche (age at onset); CESC cis rs56804039 1.000 rs11780966 chr8:8383396 T/G cg15556689 chr8:8085844 FLJ10661 -0.49 -5.31 -0.31 2.27e-7 Cervical cancer; CESC cis rs10743315 0.778 rs10841184 chr12:19370768 T/G cg02471346 chr12:19282374 PLEKHA5 -0.48 -5.2 -0.3 4.07e-7 Gut microbiota (bacterial taxa); CESC cis rs9388451 0.874 rs1159974 chr6:126090277 C/T cg10911889 chr6:126070802 HEY2 -0.39 -5.26 -0.31 3e-7 Brugada syndrome; CESC cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg06577658 chr19:46296270 DMWD 0.49 5.75 0.33 2.45e-8 Coronary artery disease; CESC cis rs2456568 0.548 rs4753113 chr11:93660974 G/A cg26875233 chr11:93583750 C11orf90 -0.32 -5.66 -0.33 3.88e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs10992471 0.575 rs1152759 chr9:95129359 T/C cg13798575 chr9:95087839 CENPP;NOL8 0.4 5.04 0.3 8.5e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs8114671 0.562 rs6120758 chr20:33492523 C/T cg06115741 chr20:33292138 TP53INP2 0.48 5.79 0.34 1.97e-8 Height; CESC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -6.84 -0.39 5.61e-11 Bipolar disorder and schizophrenia; CESC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg07507251 chr3:52567010 NT5DC2 0.41 7.12 0.4 1.02e-11 Bipolar disorder; CESC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.32 0.41 2.95e-12 Electroencephalogram traits; CESC cis rs875971 0.545 rs12671152 chr7:65776127 G/T cg25405998 chr7:65216604 CCT6P1 0.51 5.54 0.32 7.38e-8 Aortic root size; CESC cis rs2404602 0.716 rs4886817 chr15:76877702 C/T cg26408565 chr15:76604113 ETFA -0.4 -5.65 -0.33 4.24e-8 Blood metabolite levels; CESC cis rs4568518 0.710 rs13230836 chr7:18013895 A/T cg03009463 chr7:17980271 SNX13 0.47 6.29 0.36 1.33e-9 Measles; CESC cis rs6912958 1.000 rs9294380 chr6:88152667 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -5.36 -0.31 1.81e-7 Monocyte percentage of white cells; CESC cis rs761746 0.921 rs761747 chr22:32001835 C/A cg25791279 chr22:32026902 PISD 0.58 6.85 0.39 5.13e-11 Intelligence; CESC cis rs12579753 0.879 rs7971664 chr12:82264101 T/C cg24719984 chr12:82153464 PPFIA2 -0.35 -5.16 -0.3 4.96e-7 Resting heart rate; CESC cis rs2228479 0.702 rs17233441 chr16:89817998 C/G cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs2243480 0.901 rs778732 chr7:65822360 C/T cg12463550 chr7:65579703 CRCP 0.71 5.39 0.31 1.57e-7 Diabetic kidney disease; CESC trans rs61931739 0.500 rs3922568 chr12:34560107 A/C cg26384229 chr12:38710491 ALG10B 0.53 7.4 0.41 1.81e-12 Morning vs. evening chronotype; CESC cis rs6662572 0.906 rs76438782 chr1:46240425 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.2 0.3 3.91e-7 Blood protein levels; CESC cis rs5769765 0.954 rs5770709 chr22:50245196 G/T cg02269571 chr22:50332266 NA 0.45 6.04 0.35 5.28e-9 Schizophrenia; CESC cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg04455712 chr21:45112962 RRP1B 0.39 6.12 0.35 3.44e-9 Mean corpuscular volume; CESC cis rs3126085 0.935 rs4534386 chr1:152251714 A/G cg03465714 chr1:152285911 FLG -0.46 -5.75 -0.33 2.42e-8 Atopic dermatitis; CESC cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg21573476 chr21:45109991 RRP1B -0.53 -8.01 -0.44 3.68e-14 Mean corpuscular volume; CESC cis rs651907 0.557 rs11917682 chr3:101355427 G/A cg12386194 chr3:101231763 SENP7 0.44 5.37 0.31 1.71e-7 Colorectal cancer; CESC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg17971929 chr21:40555470 PSMG1 -0.6 -7.82 -0.43 1.24e-13 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07017209 chr1:220263177 BPNT1 0.65 7.79 0.43 1.5700000000000001e-13 Gut microbiome composition (summer); CESC cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 10.02 0.52 2.95e-20 Platelet count; CESC cis rs9467711 0.606 rs9379901 chr6:26603866 T/C cg12826209 chr6:26865740 GUSBL1 0.66 5.86 0.34 1.4e-8 Autism spectrum disorder or schizophrenia; CESC cis rs9303401 0.614 rs2240719 chr17:56582477 G/C cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.14 0.6 2.94e-27 Cognitive test performance; CESC cis rs9287719 0.967 rs7355649 chr2:10748094 C/A cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.36e-7 Prostate cancer; CESC cis rs11718455 0.960 rs11920021 chr3:44000856 T/C cg08738300 chr3:44038990 NA 0.46 6.14 0.35 3.03e-9 Coronary artery disease; CESC cis rs6032067 0.929 rs17334064 chr20:43839197 T/C cg11264863 chr20:43835661 SEMG1 0.48 5.26 0.31 2.98e-7 Blood protein levels; CESC trans rs1945213 0.694 rs7116741 chr11:55862620 C/T cg03929089 chr4:120376271 NA 0.77 7.35 0.41 2.48e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs2073300 0.609 rs6137939 chr20:23390206 C/T cg12062639 chr20:23401060 NAPB -1.05 -9.01 -0.48 4.22e-17 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs854765 0.647 rs854814 chr17:18003648 G/A cg09796270 chr17:17721594 SREBF1 0.38 5.15 0.3 5.05e-7 Total body bone mineral density; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24109975 chr19:59055787 TRIM28 -0.45 -6.11 -0.35 3.59e-9 Ulcerative colitis; CESC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg06481639 chr22:41940642 POLR3H -0.64 -6.58 -0.37 2.54e-10 Vitiligo; CESC cis rs1957429 0.808 rs7149922 chr14:65334541 C/T cg23373153 chr14:65346875 NA 0.89 9.19 0.49 1.19e-17 Pediatric areal bone mineral density (radius); CESC cis rs367943 0.698 rs10046061 chr5:112976533 A/G cg12552261 chr5:112820674 MCC 0.43 5.46 0.32 1.09e-7 Type 2 diabetes; CESC cis rs4664308 0.618 rs3792192 chr2:160886875 G/A cg03641300 chr2:160917029 PLA2R1 -0.59 -8.54 -0.46 1.06e-15 Idiopathic membranous nephropathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25588969 chr20:25388199 GINS1 0.59 6.35 0.36 9.45e-10 Gut microbiome composition (summer); CESC cis rs2380220 0.541 rs72928277 chr6:96079745 G/T cg23517279 chr6:96025343 MANEA -0.55 -5.38 -0.31 1.6e-7 Behavioural disinhibition (generation interaction); CESC cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2286503 0.780 rs12113458 chr7:22855628 G/T cg11367502 chr7:22862612 TOMM7 0.4 5.32 0.31 2.26e-7 Fibrinogen; CESC cis rs9611565 0.921 rs8137373 chr22:41729216 A/G cg17376030 chr22:41985996 PMM1 -0.52 -5.68 -0.33 3.63e-8 Vitiligo; CESC cis rs7089973 0.584 rs6585300 chr10:116639889 A/C cg03647239 chr10:116582469 FAM160B1 0.46 5.97 0.34 7.42e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs116095464 0.558 rs6874745 chr5:264527 A/G cg20965017 chr5:231967 SDHA -0.48 -5.43 -0.32 1.25e-7 Breast cancer; CESC cis rs6754311 0.597 rs2278544 chr2:136546110 A/G cg07169764 chr2:136633963 MCM6 -0.74 -9.4 -0.5 2.65e-18 Mosquito bite size; CESC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg11764359 chr7:65958608 NA 0.93 14.69 0.67 3.92e-36 Aortic root size; CESC cis rs73001065 0.901 rs73004926 chr19:19671266 C/T cg03709012 chr19:19516395 GATAD2A 0.97 5.93 0.34 9.39e-9 LDL cholesterol; CESC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg22638593 chr5:131593259 PDLIM4 -0.41 -5.36 -0.31 1.82e-7 Breast cancer; CESC cis rs6964587 0.869 rs11769726 chr7:91485231 A/G cg17063962 chr7:91808500 NA -0.5 -6.56 -0.37 2.77e-10 Breast cancer; CESC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg26850624 chr5:429559 AHRR -0.49 -6.62 -0.38 1.98e-10 Cystic fibrosis severity; CESC cis rs208520 0.609 rs208436 chr6:66897470 G/A cg07460842 chr6:66804631 NA -0.7 -8.83 -0.48 1.47e-16 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23496400 chr2:17721775 VSNL1 0.51 6.97 0.39 2.5e-11 Gut microbiome composition (summer); CESC trans rs1116547 0.501 rs67020702 chr5:112897619 A/G cg10115368 chr14:100435663 NA 0.5 6.1 0.35 3.72e-9 Cerebral amyloid angiopathy; CESC cis rs6662572 0.950 rs111971542 chr1:46235998 A/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 5.34 0.31 2.04e-7 Blood protein levels; CESC cis rs734999 0.588 rs2764841 chr1:2529360 G/A cg20673091 chr1:2541236 MMEL1 -0.44 -7.5 -0.42 9.48e-13 Ulcerative colitis; CESC cis rs1580019 0.587 rs34488151 chr7:32548146 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.39 0.37 7.42e-10 Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15233126 chr3:40566533 ZNF621 0.6 7.34 0.41 2.57e-12 Gut microbiome composition (summer); CESC cis rs12911832 0.701 rs452698 chr15:59105571 A/G cg05156742 chr15:59063176 FAM63B 0.72 10.04 0.52 2.61e-20 Schizophrenia; CESC trans rs7839040 0.698 rs13273019 chr8:82925431 T/C cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07132517 chr11:842517 TSPAN4;POLR2L -0.48 -6.23 -0.36 1.83e-9 Ulcerative colitis; CESC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg11764359 chr7:65958608 NA -0.48 -6.06 -0.35 4.55e-9 Calcium levels; CESC cis rs9914988 0.887 rs12947735 chr17:27156866 A/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09026875 chr17:60501189 METTL2A 0.64 7.88 0.44 8.32e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08663669 chr6:70506547 LMBRD1 -0.6 -7.24 -0.41 4.76e-12 Gut microbiome composition (summer); CESC cis rs7107174 1.000 rs948662 chr11:77979829 A/G cg02023728 chr11:77925099 USP35 0.48 6.86 0.39 4.75e-11 Testicular germ cell tumor; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01918552 chr6:163521371 PACRG 0.41 6.64 0.38 1.79e-10 Fibrinogen levels; CESC cis rs72627123 0.867 rs8019192 chr14:74471267 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.8 5.77 0.33 2.2e-8 Morning vs. evening chronotype; CESC cis rs11190604 1.000 rs3750720 chr10:102248884 C/T cg07080220 chr10:102295463 HIF1AN 0.62 5.93 0.34 9.36e-9 Palmitoleic acid (16:1n-7) levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20449327 chr14:59951241 C14orf149;JKAMP 0.56 6.05 0.35 4.95e-9 Gut microbiome composition (summer); CESC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg00080972 chr5:178986291 RUFY1 0.47 7.26 0.41 4.23e-12 Lung cancer; CESC cis rs2180341 1.000 rs6569480 chr6:127621748 A/G cg27446573 chr6:127587934 RNF146 1.02 15.87 0.7 2.5e-40 Breast cancer; CESC cis rs4835473 0.742 rs7695853 chr4:144804396 G/C cg25736465 chr4:144833511 NA 0.41 6.3 0.36 1.26e-9 Immature fraction of reticulocytes; CESC cis rs8180040 0.726 rs4682842 chr3:46982773 C/G cg27129171 chr3:47204927 SETD2 -0.64 -9.04 -0.49 3.43e-17 Colorectal cancer; CESC cis rs11098499 0.866 rs12501602 chr4:120287935 A/T cg24375607 chr4:120327624 NA 0.41 5.13 0.3 5.7e-7 Corneal astigmatism; CESC cis rs962856 0.619 rs1032158 chr2:67601028 A/C cg09028215 chr2:67624308 ETAA1 -0.42 -5.1 -0.3 6.49e-7 Pancreatic cancer; CESC cis rs6089584 0.526 rs6061965 chr20:60607858 A/C cg24733560 chr20:60626293 TAF4 0.44 6.58 0.37 2.46e-10 Body mass index; CESC cis rs11583043 0.957 rs6667932 chr1:101503755 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 5.26 0.31 2.91e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs933688 0.938 rs6866923 chr5:90669352 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 1.02 14.19 0.66 2.24e-34 Smoking behavior; CESC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg24531977 chr5:56204891 C5orf35 1.0 13.17 0.63 8.1e-31 Initial pursuit acceleration; CESC cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg22875332 chr1:76189707 ACADM 0.72 10.03 0.52 2.87e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9487051 0.676 rs9386788 chr6:109600523 C/T cg21918786 chr6:109611834 NA 0.37 5.46 0.32 1.12e-7 Reticulocyte fraction of red cells; CESC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg06873352 chr17:61820015 STRADA 0.72 12.78 0.62 1.79e-29 Prudent dietary pattern; CESC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg20243544 chr17:37824526 PNMT 0.49 6.17 0.35 2.58e-9 Glomerular filtration rate (creatinine); CESC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg25204440 chr1:209979598 IRF6 0.7 8.66 0.47 4.75e-16 Cleft lip with or without cleft palate; CESC cis rs12220238 0.554 rs10824192 chr10:76251573 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.09 0.3 6.95e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs433852 0.718 rs550455 chr19:49136515 A/G cg06677660 chr19:49140777 SEC1;DBP -0.45 -5.49 -0.32 9.3e-8 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; CESC cis rs4727027 0.933 rs62505074 chr7:148834780 C/T cg23583168 chr7:148888333 NA -0.73 -10.82 -0.55 7.76e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg07414643 chr4:187882934 NA 0.49 7.0 0.39 2.16e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.898 rs8072297 chr17:37478048 A/T cg15445000 chr17:37608096 MED1 -0.45 -7.43 -0.42 1.47e-12 Glomerular filtration rate (creatinine); CESC cis rs909674 0.662 rs2899318 chr22:39837625 A/G cg05872129 chr22:39784769 NA -0.8 -10.41 -0.54 1.75e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9322193 0.884 rs7769115 chr6:150169932 C/T cg09699651 chr6:150184138 LRP11 0.5 6.29 0.36 1.31e-9 Lung cancer; CESC cis rs7772486 0.632 rs9386128 chr6:146049053 G/A cg05347473 chr6:146136440 FBXO30 -0.52 -6.93 -0.39 3.22e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14538439 chr10:90750381 FAS;ACTA2 -0.47 -6.45 -0.37 5.28e-10 Fibrinogen levels; CESC cis rs11031096 0.711 rs1348309 chr11:4202000 A/T cg18678763 chr11:4115507 RRM1 -0.39 -5.06 -0.3 7.72e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs4700695 0.719 rs27085 chr5:65435063 C/T cg21114390 chr5:65439923 SFRS12 0.47 5.8 0.34 1.9e-8 Facial morphology (factor 19); CESC cis rs6580649 0.831 rs4760620 chr12:48559642 A/G cg05342945 chr12:48394962 COL2A1 -0.54 -6.17 -0.35 2.56e-9 Lung cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10784777 chr12:56552019 MYL6 -0.44 -6.08 -0.35 4.15e-9 Asthma; CESC cis rs6977955 1.000 rs917117 chr7:28176305 G/A cg23620719 chr7:28220237 JAZF1 0.52 5.88 0.34 1.23e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs2066819 1.000 rs2371454 chr12:56647243 A/G cg26804944 chr12:56660921 COQ10A 0.85 5.19 0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs75887402 0.744 rs4836002 chr5:122676161 A/G cg27033705 chr5:122759302 CEP120 -0.74 -5.07 -0.3 7.39e-7 Breast cancer; CESC cis rs4843747 0.749 rs72818535 chr16:88074039 G/A cg17633681 chr16:88106987 BANP 0.69 9.01 0.48 4.24e-17 Menopause (age at onset); CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg08327423 chr16:84150746 MBTPS1 -0.52 -5.99 -0.35 6.64e-9 Subjective well-being; CESC cis rs4728302 0.869 rs958405 chr7:133597151 A/G cg10665199 chr7:133106180 EXOC4 0.42 5.89 0.34 1.16e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg01448562 chr3:133502909 NA -0.58 -8.45 -0.46 1.9e-15 Iron status biomarkers; CESC cis rs6460942 0.732 rs73677575 chr7:12286532 A/G cg20607287 chr7:12443886 VWDE -0.59 -6.43 -0.37 5.83e-10 Coronary artery disease; CESC cis rs2380220 0.541 rs72928277 chr6:96079745 G/T cg15832292 chr6:96025679 MANEA -0.77 -8.1 -0.45 2.07e-14 Behavioural disinhibition (generation interaction); CESC trans rs7980799 1.000 rs7980799 chr12:33576990 A/C cg26384229 chr12:38710491 ALG10B -0.53 -7.24 -0.41 4.75e-12 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs10489525 0.599 rs7526323 chr1:115604241 G/A cg12756093 chr1:115239321 AMPD1 -0.45 -5.44 -0.32 1.19e-7 Autism; CESC cis rs4660306 0.744 rs11211114 chr1:45926243 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.11 0.3 6.24e-7 Homocysteine levels; CESC cis rs933688 0.532 rs11740007 chr5:90545498 C/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.46 -5.49 -0.32 9.43e-8 Smoking behavior; CESC trans rs9929218 0.954 rs72785165 chr16:68755635 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -9.95 -0.52 5.04e-20 Colorectal cancer; CESC cis rs3106136 0.967 rs2129595 chr4:95224454 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.73 -0.38 1.02e-10 Capecitabine sensitivity; CESC cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17142371 chr1:155278522 FDPS 0.67 7.22 0.41 5.47e-12 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg26314531 chr2:26401878 FAM59B -0.77 -8.56 -0.47 9.38e-16 Gut microbiome composition (summer); CESC cis rs698833 0.892 rs1067322 chr2:44630107 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 6.47 0.37 4.61e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg10691866 chr7:65817282 TPST1 0.32 5.36 0.31 1.8e-7 Aortic root size; CESC cis rs826838 0.935 rs11169547 chr12:39185625 C/A cg26384229 chr12:38710491 ALG10B 0.78 13.13 0.63 1.09e-30 Heart rate; CESC cis rs1008375 0.835 rs9760627 chr4:17651508 C/T cg27347728 chr4:17578864 LAP3 0.43 5.08 0.3 7e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9549367 0.789 rs9549361 chr13:113898329 C/T cg18105134 chr13:113819100 PROZ 0.66 7.92 0.44 6.44e-14 Platelet distribution width; CESC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg26335602 chr6:28129616 ZNF389 0.48 6.63 0.38 1.9e-10 Depression; CESC cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg23711669 chr6:146136114 FBXO30 0.9 13.27 0.63 3.71e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg24308560 chr3:49941425 MST1R 0.61 9.02 0.48 4.04e-17 Intelligence (multi-trait analysis); CESC cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.21 0.53 7.18e-21 Monocyte percentage of white cells; CESC cis rs2243480 0.901 rs58207111 chr7:65486723 C/T cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC cis rs9914544 1.000 rs1037036 chr17:18764077 C/T cg26378065 chr17:18585709 ZNF286B 0.43 5.06 0.3 7.84e-7 Educational attainment (years of education); CESC cis rs2228479 0.867 rs75110337 chr16:89962635 C/A cg00800038 chr16:89945340 TCF25 -0.84 -7.29 -0.41 3.49e-12 Skin colour saturation; CESC cis rs713587 0.967 rs6752378 chr2:25150116 C/A cg01884057 chr2:25150051 NA 0.43 8.02 0.44 3.42e-14 Body mass index in non-asthmatics; CESC cis rs7851660 0.870 rs55960649 chr9:100598695 C/A cg13688889 chr9:100608707 NA -0.69 -10.74 -0.55 1.39e-22 Strep throat; CESC cis rs9911578 1.000 rs304299 chr17:56838472 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.16 0.3 4.76e-7 Intelligence (multi-trait analysis); CESC cis rs11098499 0.865 rs4001305 chr4:120359236 G/T cg09307838 chr4:120376055 NA 0.95 13.78 0.65 6.32e-33 Corneal astigmatism; CESC cis rs11864453 0.614 rs12445586 chr16:72126276 C/T cg01557791 chr16:72042693 DHODH -0.46 -5.92 -0.34 9.98e-9 Fibrinogen levels; CESC cis rs397969 0.596 rs17668529 chr17:19899788 G/T cg12073167 chr17:19770448 ULK2 -0.47 -5.34 -0.31 2.04e-7 Platelet count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00336706 chr5:43064908 NA -0.52 -6.21 -0.36 2.05e-9 Ulcerative colitis; CESC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg16405210 chr4:1374714 KIAA1530 0.44 5.53 0.32 7.67e-8 Obesity-related traits; CESC cis rs644799 0.648 rs1255176 chr11:95471465 A/T cg03916912 chr11:95522834 CEP57;FAM76B 0.47 6.74 0.38 9.72e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7264396 0.790 rs6060542 chr20:34249061 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.77 0.43 1.78e-13 Total cholesterol levels; CESC cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.79 13.08 0.63 1.72e-30 Personality dimensions; CESC cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg06453172 chr10:134556979 INPP5A -0.4 -5.43 -0.32 1.3e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg20887711 chr4:1340912 KIAA1530 0.52 6.72 0.38 1.13e-10 Obesity-related traits; CESC cis rs2066819 1.000 rs2306693 chr12:56680531 T/C cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs17376456 0.569 rs11135394 chr5:93187135 C/T cg25358565 chr5:93447407 FAM172A -0.44 -5.05 -0.3 8.12e-7 Diabetic retinopathy; CESC cis rs10479542 0.503 rs12719865 chr5:178993566 C/T cg19723775 chr5:179050963 HNRNPH1 0.41 5.32 0.31 2.23e-7 Lung cancer; CESC trans rs2235573 0.527 rs5756853 chr22:38329524 G/A cg19894588 chr14:64061835 NA -0.58 -7.5 -0.42 9.69e-13 Glioblastoma;Glioma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14946105 chr17:8021876 ALOXE3 -0.59 -7.01 -0.4 2.02e-11 Gut microbiome composition (summer); CESC trans rs9929218 0.551 rs2296406 chr16:68721340 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.97 17.13 0.72 8.49e-45 Colorectal cancer; CESC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.42e-7 Life satisfaction; CESC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg23172400 chr8:95962367 TP53INP1 -0.43 -8.96 -0.48 6e-17 Type 2 diabetes; CESC cis rs2806561 0.828 rs944509 chr1:23542242 C/T cg12483005 chr1:23474871 LUZP1 -0.33 -5.33 -0.31 2.07e-7 Height; CESC cis rs7998202 0.720 rs914020 chr13:113352848 C/G cg02820901 chr13:113351484 ATP11A 0.63 6.04 0.35 5.07e-9 Glycated hemoglobin levels; CESC cis rs2243480 1.000 rs778679 chr7:65840911 A/G cg18252515 chr7:66147081 NA -1.39 -14.18 -0.66 2.5e-34 Diabetic kidney disease; CESC cis rs3820068 0.603 rs16851884 chr1:15961871 A/G cg16988262 chr1:15930761 NA 0.34 5.45 0.32 1.16e-7 Systolic blood pressure; CESC cis rs3862030 0.503 rs10786673 chr10:104280537 G/A cg22532475 chr10:104410764 TRIM8 -0.33 -5.67 -0.33 3.77e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs60154123 0.505 rs76101197 chr1:210044089 T/C cg25204440 chr1:209979598 IRF6 0.69 6.5 0.37 3.96e-10 Coronary artery disease; CESC cis rs7927771 0.965 rs11039416 chr11:47846711 G/A cg18512352 chr11:47633146 NA -0.6 -9.57 -0.51 8.16e-19 Subjective well-being; CESC cis rs1178968 1.000 rs2353062 chr7:72740048 C/T cg25889504 chr7:72793014 NA 0.47 5.03 0.3 8.91e-7 Triglyceride levels; CESC cis rs4268898 0.662 rs714531 chr2:24399877 G/A cg20701182 chr2:24300061 SF3B14 0.72 7.23 0.41 5.21e-12 Asthma; CESC cis rs4722166 0.695 rs35779989 chr7:22800314 A/C cg05472934 chr7:22766657 IL6 0.63 8.25 0.45 7.5e-15 Lung cancer; CESC cis rs6570726 0.902 rs973855 chr6:145781850 C/T cg23711669 chr6:146136114 FBXO30 -0.73 -10.75 -0.55 1.35e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs963731 0.649 rs297149 chr2:39324469 G/C cg04010122 chr2:39346883 SOS1 -0.74 -5.39 -0.31 1.53e-7 Corticobasal degeneration; CESC cis rs4716602 0.896 rs4716427 chr7:156166490 C/T cg04090468 chr7:156181990 NA -0.39 -5.17 -0.3 4.54e-7 Anti-saccade response; CESC cis rs7208859 0.673 rs12103588 chr17:29197460 C/T cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg03647317 chr4:187891568 NA -0.39 -5.83 -0.34 1.57e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs13064411 0.696 rs6799610 chr3:113248748 A/C cg18753928 chr3:113234510 CCDC52 0.46 5.3 0.31 2.5e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs6439153 0.933 rs1871951 chr3:128720487 A/G cg24203234 chr3:128598194 ACAD9 0.42 5.48 0.32 9.9e-8 Pneumococcal bacteremia; CESC cis rs2109514 0.870 rs6976316 chr7:116122943 G/A cg12739419 chr7:116140593 CAV2 -0.38 -6.75 -0.38 9.22e-11 Prevalent atrial fibrillation; CESC cis rs2228479 0.717 rs1061647 chr16:89806063 G/C cg06558623 chr16:89946397 TCF25 1.12 8.63 0.47 5.8e-16 Skin colour saturation; CESC cis rs2243480 1.000 rs1167613 chr7:65487439 C/T cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs66887589 0.616 rs6843509 chr4:120220196 G/A cg09307838 chr4:120376055 NA 0.67 9.16 0.49 1.51e-17 Diastolic blood pressure; CESC cis rs1355223 0.583 rs2941057 chr11:34882220 G/A cg11058730 chr11:34937778 PDHX;APIP 0.84 13.04 0.63 2.37e-30 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs75229567 0.618 rs11177849 chr12:70182473 C/T cg10114359 chr12:70132523 RAB3IP -1.02 -7.08 -0.4 1.31e-11 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg22903657 chr4:1355424 KIAA1530 -0.41 -5.77 -0.33 2.22e-8 Obesity-related traits; CESC cis rs7639513 0.545 rs55977822 chr3:12704438 C/A cg23032965 chr3:12705835 RAF1 0.7 7.82 0.43 1.29e-13 Itch intensity from mosquito bite; CESC cis rs1348850 0.914 rs4893938 chr2:178250095 T/C cg22681709 chr2:178499509 PDE11A -0.44 -6.55 -0.37 3.02e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg22903471 chr2:27725779 GCKR -0.5 -7.15 -0.4 8.58e-12 Total body bone mineral density; CESC cis rs12971120 0.685 rs34780792 chr18:72173278 G/A cg25817165 chr18:72167213 CNDP2 -0.62 -7.22 -0.41 5.48e-12 Refractive error; CESC cis rs863345 0.604 rs10908665 chr1:158499889 T/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg21782813 chr7:2030301 MAD1L1 0.44 6.31 0.36 1.14e-9 Bipolar disorder and schizophrenia; CESC cis rs425277 0.958 rs262687 chr1:2117155 G/A cg16545954 chr1:2118288 C1orf86 0.32 5.3 0.31 2.5e-7 Height; CESC cis rs10870270 1.000 rs7078692 chr10:133775370 T/A cg17892150 chr10:133769511 PPP2R2D -0.86 -12.56 -0.61 1.08e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs9900062 1.000 rs9900062 chr17:62739574 G/A cg02598441 chr17:62777298 LOC146880 -0.51 -5.33 -0.31 2.11e-7 QT interval; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg13445258 chr3:128369860 RPN1 0.51 6.67 0.38 1.45e-10 Obesity-related traits; CESC cis rs2625529 0.617 rs2957365 chr15:72348106 C/T cg16672083 chr15:72433130 SENP8 0.46 7.08 0.4 1.26e-11 Red blood cell count; CESC cis rs362296 0.661 rs3095078 chr4:3265479 C/T cg08886695 chr4:3369023 RGS12 0.38 5.24 0.31 3.34e-7 Parental longevity (mother's age at death); CESC cis rs12136530 0.562 rs12125959 chr1:19735262 A/G cg01832549 chr1:19774989 CAPZB -0.45 -6.28 -0.36 1.4e-9 Lead levels in blood; CESC cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg08873628 chr1:175162347 KIAA0040 -0.45 -5.64 -0.33 4.39e-8 Diastolic blood pressure; CESC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg00074818 chr8:8560427 CLDN23 0.36 5.22 0.31 3.65e-7 Obesity-related traits; CESC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg08736216 chr1:53307985 ZYG11A 0.3 5.05 0.3 8.32e-7 Monocyte count; CESC cis rs7301826 0.651 rs10734981 chr12:131297895 C/G cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC trans rs57221529 0.563 rs4957057 chr5:569230 C/G cg25482853 chr8:67687455 SGK3 0.97 10.18 0.53 9.16e-21 Lung disease severity in cystic fibrosis; CESC cis rs7084402 0.967 rs1626532 chr10:60294685 A/T cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.35e-18 Refractive error; CESC cis rs2066819 1.000 rs41423244 chr12:56693520 A/C cg26734620 chr12:56694298 CS -1.02 -6.2 -0.36 2.16e-9 Psoriasis vulgaris; CESC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.99 0.35 6.63e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.59 -0.38 2.43e-10 Life satisfaction; CESC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg11890956 chr21:40555474 PSMG1 -0.9 -13.98 -0.65 1.17e-33 Cognitive function; CESC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg24503407 chr1:205819492 PM20D1 0.78 12.28 0.6 1e-27 Menarche (age at onset); CESC cis rs7208859 0.623 rs9896603 chr17:29078512 C/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg18350739 chr11:68623251 NA -0.44 -6.8 -0.39 6.75e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg24110177 chr3:50126178 RBM5 -0.54 -7.23 -0.41 5.19e-12 Intelligence (multi-trait analysis); CESC cis rs854765 0.583 rs6502627 chr17:17849671 C/T cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg19748678 chr4:122722346 EXOSC9 0.72 9.33 0.5 4.51e-18 Type 2 diabetes; CESC cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg01579765 chr21:45077557 HSF2BP -0.55 -9.2 -0.49 1.07e-17 Mean corpuscular volume; CESC cis rs9329289 0.510 rs9733402 chr10:2551532 G/A cg15501526 chr10:2543763 NA 0.47 7.56 0.42 6.51e-13 Age-related hearing impairment; CESC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg11742103 chr11:62369870 EML3;MTA2 0.63 9.22 0.49 9.6e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2832191 0.636 rs8131283 chr21:30516796 A/G cg24692254 chr21:30365293 RNF160 -0.63 -7.76 -0.43 1.87e-13 Dental caries; CESC cis rs1707322 1.000 rs1707338 chr1:46511981 T/G cg03146154 chr1:46216737 IPP -0.72 -9.73 -0.51 2.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22219489 chr4:122745136 CCNA2 0.55 6.34 0.36 9.69e-10 Gut microbiome composition (summer); CESC cis rs2404602 0.692 rs12910382 chr15:77053442 A/C cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg23758822 chr17:41437982 NA 1.0 15.37 0.69 1.56e-38 Menopause (age at onset); CESC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg06808227 chr14:105710500 BRF1 -0.61 -7.85 -0.43 1.07e-13 Mean platelet volume;Platelet distribution width; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11380830 chr10:96123085 NOC3L 0.46 6.26 0.36 1.53e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.5 0.37 3.97e-10 Bipolar disorder; CESC cis rs1198430 0.636 rs2811963 chr1:23824242 A/C cg22040403 chr1:23858016 E2F2 0.64 5.74 0.33 2.63e-8 Total cholesterol levels; CESC cis rs4555082 0.718 rs75139030 chr14:105710853 A/AG cg13114125 chr14:105738426 BRF1 -0.86 -10.3 -0.53 3.86e-21 Mean platelet volume;Platelet distribution width; CESC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs7726839 0.540 rs4957083 chr5:659343 T/C cg16447950 chr5:562315 NA -0.59 -6.46 -0.37 4.92e-10 Obesity-related traits; CESC cis rs7818688 0.697 rs17665714 chr8:95982542 T/C cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs4867766 0.789 rs17781920 chr5:173955939 G/A cg20434911 chr5:173954559 NA -0.59 -6.34 -0.36 9.87e-10 Stroke; CESC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg19592336 chr6:28129416 ZNF389 0.52 7.19 0.4 6.45e-12 Depression; CESC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg07936489 chr17:37558343 FBXL20 -0.82 -12.22 -0.6 1.6e-27 Glomerular filtration rate (creatinine); CESC cis rs4481887 1.000 rs7517319 chr1:248466408 C/A cg00666640 chr1:248458726 OR2T12 0.39 6.37 0.36 8.47e-10 Common traits (Other); CESC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg13393036 chr8:95962371 TP53INP1 -0.55 -12.75 -0.62 2.44e-29 Type 2 diabetes; CESC cis rs7914558 1.000 rs10883824 chr10:104812897 A/G cg08650961 chr10:104748594 CNNM2 0.31 5.17 0.3 4.67e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg08645402 chr16:4508243 NA 0.43 6.25 0.36 1.64e-9 Schizophrenia; CESC trans rs35110281 0.776 rs2838338 chr21:45075582 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 6.82 0.39 6.27e-11 Mean corpuscular volume; CESC cis rs3762637 1.000 rs9968189 chr3:122175136 G/A cg24169773 chr3:122142474 KPNA1 -0.54 -6.33 -0.36 1.04e-9 LDL cholesterol levels; CESC cis rs10779751 0.960 rs1883965 chr1:11322156 A/G cg08854313 chr1:11322531 MTOR 0.81 11.1 0.56 9.33e-24 Body mass index; CESC cis rs6831352 0.819 rs1230158 chr4:99990186 T/C cg21548116 chr4:100009993 ADH5 0.49 5.39 0.31 1.58e-7 Alcohol dependence; CESC cis rs6736093 0.871 rs35471545 chr2:112756711 T/G cg12686935 chr2:112915763 FBLN7 -0.41 -5.56 -0.32 6.64e-8 Coronary artery disease; CESC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 12.62 0.61 6.7200000000000006e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6598955 0.724 rs3924934 chr1:26644079 A/G cg00852783 chr1:26633632 UBXN11 0.43 6.24 0.36 1.75e-9 Obesity-related traits; CESC cis rs6499129 0.867 rs8056770 chr16:67416730 A/C cg26727032 chr16:67993705 SLC12A4 -0.52 -5.87 -0.34 1.27e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.47 -7.89 -0.44 7.88e-14 Hemoglobin concentration; CESC cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7917772 0.503 rs7915589 chr10:104299264 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.19 0.3 4.1e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs34779708 0.733 rs12240638 chr10:35542610 G/T cg03585969 chr10:35415529 CREM 0.56 6.42 0.37 6.15e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs9858542 0.953 rs9859556 chr3:49455986 G/T cg21659725 chr3:3221576 CRBN -0.56 -6.6 -0.38 2.17e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.17 -0.35 2.51e-9 Mood instability; CESC cis rs6120849 0.754 rs17319032 chr20:33643296 T/C cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg18099408 chr3:52552593 STAB1 -0.3 -5.11 -0.3 6.18e-7 Bipolar disorder; CESC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.6 -8.36 -0.46 3.59e-15 Platelet count; CESC cis rs2736345 0.516 rs9657551 chr8:11398183 A/G cg09528494 chr8:11338675 NA 0.32 6.03 0.35 5.34e-9 Sjögren's syndrome;Systemic lupus erythematosus; CESC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg14196790 chr5:131705035 SLC22A5 -0.34 -5.36 -0.31 1.81e-7 Breast cancer; CESC cis rs1707322 0.835 rs946525 chr1:46487277 A/T cg05343316 chr1:45956843 TESK2 -0.45 -5.54 -0.32 7.32e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs76878669 0.561 rs1892940 chr11:66111251 A/G cg18002602 chr11:66138449 SLC29A2 -0.41 -6.68 -0.38 1.39e-10 Educational attainment (years of education); CESC cis rs4148883 0.629 rs2602899 chr4:100010128 C/T cg12011299 chr4:100065546 ADH4 0.66 9.57 0.51 7.76e-19 Alcohol dependence; CESC cis rs10883723 0.810 rs913025 chr10:104276043 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -5.9 -0.34 1.13e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg11764359 chr7:65958608 NA 0.68 8.69 0.47 3.76e-16 Calcium levels; CESC cis rs4595586 0.545 rs4411311 chr12:39363612 C/G cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs5753618 0.555 rs9609302 chr22:31895987 A/C cg02404636 chr22:31891804 SFI1 0.42 5.64 0.33 4.35e-8 Colorectal cancer; CESC cis rs35079168 0.961 rs66475113 chr9:137284381 C/T cg13941235 chr9:137270186 RXRA -0.31 -5.55 -0.32 7e-8 Intelligence; CESC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg17372223 chr3:52568218 NT5DC2 0.43 6.43 0.37 5.84e-10 Bipolar disorder; CESC cis rs7072216 0.763 rs7910247 chr10:100172252 C/T cg26618903 chr10:100175079 PYROXD2 -0.38 -5.86 -0.34 1.38e-8 Metabolite levels; CESC cis rs35146811 0.844 rs13223792 chr7:99675659 T/G cg13334819 chr7:99746414 C7orf59 -0.42 -5.14 -0.3 5.27e-7 Coronary artery disease; CESC cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg11752832 chr7:134001865 SLC35B4 0.51 6.52 0.37 3.54e-10 Mean platelet volume; CESC cis rs11166629 1.000 rs894349 chr8:135638055 T/C cg21672855 chr8:135614777 ZFAT 0.4 5.03 0.3 9.18e-7 Smoking quantity; CESC cis rs7927771 0.524 rs12362318 chr11:47682671 T/C cg20307385 chr11:47447363 PSMC3 0.63 8.7 0.47 3.61e-16 Subjective well-being; CESC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg07870213 chr5:140052090 DND1 -0.47 -6.07 -0.35 4.45e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2279817 0.955 rs2270977 chr1:18023509 T/C cg21791023 chr1:18019539 ARHGEF10L 0.58 8.23 0.45 8.3e-15 Neuroticism; CESC cis rs9457247 0.534 rs4710149 chr6:167386346 T/C cg25258033 chr6:167368657 RNASET2 -0.38 -5.38 -0.31 1.66e-7 Crohn's disease; CESC cis rs10911232 0.507 rs10797815 chr1:182996827 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs10851478 0.872 rs1818308 chr15:49815650 T/A cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg04450456 chr4:17643702 FAM184B 0.37 5.18 0.3 4.46e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs13082711 0.863 rs35797268 chr3:27418862 T/C cg02860705 chr3:27208620 NA 0.62 7.44 0.42 1.43e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs2294693 0.945 rs13216361 chr6:41007046 C/T cg14418226 chr6:40996092 UNC5CL 0.54 6.3 0.36 1.2e-9 Gastric cancer;Non-cardia gastric cancer; CESC cis rs916888 0.821 rs415430 chr17:44859144 C/T cg01570182 chr17:44337453 NA -0.88 -10.64 -0.55 2.96e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11098499 0.644 rs10009566 chr4:120558608 A/G cg09307838 chr4:120376055 NA 0.73 9.81 0.52 1.36e-19 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00140813 chr16:28857836 TUFM 0.54 6.26 0.36 1.55e-9 Gut microbiome composition (summer); CESC cis rs7584330 0.554 rs112402109 chr2:238429058 A/G cg14458575 chr2:238380390 NA 0.53 5.68 0.33 3.53e-8 Prostate cancer; CESC cis rs3015497 0.543 rs1565834 chr14:51011528 C/T cg26011998 chr14:51135199 SAV1 0.49 5.59 0.32 5.55e-8 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20696752 chr17:42143797 LSM12 0.57 6.27 0.36 1.47e-9 Gut microbiome composition (summer); CESC cis rs1609391 0.543 rs1347209 chr3:136626697 G/T cg15507776 chr3:136538369 TMEM22 0.82 11.97 0.59 1.08e-26 Neuroticism; CESC cis rs1062177 0.756 rs2964591 chr5:151117397 A/G cg12924095 chr5:151150029 G3BP1 -0.4 -5.11 -0.3 6.32e-7 Preschool internalizing problems; CESC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.35 -0.31 1.87e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs13102973 0.965 rs13106621 chr4:135854975 A/T cg14419869 chr4:135874104 NA 0.33 5.13 0.3 5.55e-7 Subjective well-being; CESC cis rs9527 0.568 rs1926036 chr10:104883812 C/T cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC trans rs79976124 0.797 rs78317899 chr6:66652896 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 8.75 0.47 2.61e-16 Type 2 diabetes; CESC cis rs11718455 0.960 rs17076255 chr3:44002093 C/T cg08738300 chr3:44038990 NA 0.45 6.03 0.35 5.48e-9 Coronary artery disease; CESC cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs807669 0.525 rs2282684 chr22:19184244 C/T cg02655711 chr22:19163373 SLC25A1 0.42 6.29 0.36 1.3e-9 Metabolite levels; CESC trans rs4424809 0.614 rs75435370 chr13:85572867 A/C cg05918002 chr17:5019452 ZNF232 -0.63 -6.08 -0.35 4.29e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs213032 1.000 rs213030 chr1:21653847 C/T cg16416158 chr1:21652298 ECE1 0.31 5.04 0.3 8.78e-7 Obesity-related traits; CESC cis rs67478160 0.654 rs1535097 chr14:104216649 C/T cg01849466 chr14:104193079 ZFYVE21 -0.49 -6.87 -0.39 4.53e-11 Schizophrenia; CESC cis rs11098499 0.955 rs13113112 chr4:120156040 C/T cg09307838 chr4:120376055 NA 0.86 11.38 0.57 1.05e-24 Corneal astigmatism; CESC cis rs8114671 0.839 rs2104084 chr20:33649217 G/C cg07148914 chr20:33460835 GGT7 -0.4 -5.11 -0.3 6.21e-7 Height; CESC cis rs2242194 0.844 rs11264295 chr1:154987526 C/T cg12436631 chr1:155007014 DCST1;DCST2 0.47 8.12 0.45 1.72e-14 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06196466 chr12:124933388 NCOR2 -0.55 -6.66 -0.38 1.53e-10 Gut microbiome composition (summer); CESC cis rs9462846 0.959 rs9471958 chr6:42883669 C/T cg02353165 chr6:42928485 GNMT 0.5 5.62 0.33 4.88e-8 Blood protein levels; CESC trans rs4756846 1.000 rs4756846 chr11:16403511 C/T cg26608174 chr17:46711035 MIR196A1 0.49 6.11 0.35 3.58e-9 Obesity and osteoporosis; CESC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg16132339 chr22:24313637 DDTL;DDT 0.34 5.08 0.3 7.12e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1372520 0.684 rs2572318 chr4:90718719 C/T cg15133208 chr4:90757351 SNCA -0.42 -5.71 -0.33 3.03e-8 Neuroticism; CESC cis rs6088580 0.634 rs6088512 chr20:33095891 G/A cg24642439 chr20:33292090 TP53INP2 0.5 6.55 0.37 3.05e-10 Glomerular filtration rate (creatinine); CESC cis rs765787 0.530 rs1706834 chr15:45517854 G/A cg24006582 chr15:45444508 DUOX1 -0.53 -6.47 -0.37 4.75e-10 Uric acid levels; CESC cis rs4737010 0.570 rs7823138 chr8:41644861 C/T cg08923054 chr8:41654455 ANK1 -0.52 -6.53 -0.37 3.3e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs1003719 0.788 rs7277657 chr21:38469523 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg15782153 chr7:917662 C7orf20 0.48 6.95 0.39 2.78e-11 Perceived unattractiveness to mosquitoes; CESC trans rs722599 0.562 rs2287400 chr14:75182937 G/A cg00095594 chr1:236228625 NID1 0.39 6.02 0.35 5.67e-9 IgG glycosylation; CESC cis rs67311347 0.544 rs9868700 chr3:40345408 G/A cg09455208 chr3:40491958 NA 0.37 6.51 0.37 3.77e-10 Renal cell carcinoma; CESC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs1878931 0.559 rs11643501 chr16:3392752 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.71 8.96 0.48 5.91e-17 Body mass index (adult); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03747177 chr16:23568683 EARS2;UBFD1 -0.44 -6.18 -0.35 2.41e-9 Gambling; CESC trans rs8073060 0.586 rs117573546 chr17:33909588 G/A cg19694781 chr19:47549865 TMEM160 0.73 7.01 0.4 1.96e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs2370759 1.000 rs79806114 chr10:32618022 T/C cg01819863 chr10:32635814 EPC1 1.16 12.46 0.61 2.26e-28 Sexual dysfunction (female); CESC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 9.97 0.52 4.3e-20 Prudent dietary pattern; CESC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg12412775 chr1:25698385 RHCE -0.3 -5.49 -0.32 9.37e-8 Erythrocyte sedimentation rate; CESC cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC trans rs4332037 1.000 rs62442899 chr7:1948454 C/T cg11693508 chr17:37793320 STARD3 0.68 6.51 0.37 3.77e-10 Bipolar disorder; CESC cis rs4604732 0.631 rs11490199 chr1:247625737 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg18252515 chr7:66147081 NA -0.47 -6.11 -0.35 3.53e-9 Aortic root size; CESC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.32 -5.62 -0.33 4.92e-8 Bipolar disorder; CESC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg26939375 chr7:64535504 NA 0.76 10.78 0.55 1.03e-22 Aortic root size; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg16635483 chr3:96338407 NA 0.48 6.3 0.36 1.23e-9 Recombination measurement; CESC cis rs3768617 0.811 rs12138049 chr1:182979546 C/T ch.1.3577855R chr1:183094577 LAMC1 0.66 9.0 0.48 4.41e-17 Fuchs's corneal dystrophy; CESC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg09323728 chr8:95962352 TP53INP1 -0.36 -7.64 -0.42 4.1e-13 Type 2 diabetes; CESC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg24642844 chr7:1081250 C7orf50 -0.67 -8.14 -0.45 1.59e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7953249 0.656 rs1732391 chr12:121392341 C/T cg02403541 chr12:121454288 C12orf43 -0.53 -6.88 -0.39 4.43e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs13385 0.769 rs35400561 chr5:139622265 G/A cg26211634 chr5:139558579 C5orf32 0.51 5.57 0.32 6.11e-8 Atrial fibrillation; CESC cis rs1593 0.734 rs4862670 chr4:187145423 A/T cg23442198 chr4:187126114 CYP4V2 0.64 5.15 0.3 5.16e-7 Activated partial thromboplastin time; CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg18402987 chr7:1209562 NA 0.63 7.37 0.41 2.16e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.36 0.5 3.44e-18 Menopause (age at onset); CESC trans rs1814175 0.817 rs10128730 chr11:50023369 G/T cg03929089 chr4:120376271 NA -0.94 -16.01 -0.7 7.75e-41 Height; CESC cis rs1009170 0.794 rs112924085 chr14:92581713 C/T cg10324096 chr14:92587714 CPSF2;NDUFB1 0.54 5.07 0.3 7.38e-7 Dialysis-related mortality; CESC cis rs72781680 1.000 rs17762102 chr2:24085606 A/G cg20701182 chr2:24300061 SF3B14 0.63 5.63 0.33 4.49e-8 Lymphocyte counts; CESC cis rs3733585 0.624 rs7376154 chr4:9952587 C/A cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1348850 0.668 rs2365619 chr2:178497366 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.45 -5.11 -0.3 6.23e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs428668 0.523 rs10060607 chr5:150679304 A/C cg14086364 chr5:150678334 SLC36A3 0.49 7.06 0.4 1.49e-11 Skin aging (microtopography measurement); CESC trans rs3780486 0.757 rs10121987 chr9:33119818 A/G cg04842962 chr6:43655489 MRPS18A 0.98 18.32 0.75 5.56e-49 IgG glycosylation; CESC cis rs9902453 0.765 rs2874505 chr17:28037923 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.73 9.61 0.51 5.87e-19 Coffee consumption (cups per day); CESC cis rs9486715 0.838 rs9486275 chr6:96901187 C/T cg06623918 chr6:96969491 KIAA0776 0.91 14.06 0.65 6.39e-34 Headache; CESC cis rs1692580 0.846 rs377599 chr1:2164699 C/T cg21194808 chr1:2205498 SKI 0.37 5.19 0.3 4.22e-7 Coronary artery disease; CESC cis rs11209002 0.522 rs2224502 chr1:67539439 A/G cg02640540 chr1:67518911 SLC35D1 0.47 5.39 0.31 1.52e-7 Crohn's disease; CESC cis rs4423214 0.559 rs10898201 chr11:71201527 C/A cg05163923 chr11:71159392 DHCR7 -0.65 -6.55 -0.37 2.95e-10 Vitamin D levels; CESC cis rs7799006 0.723 rs2270052 chr7:2291399 C/T cg08027265 chr7:2291960 NA -0.57 -9.9 -0.52 7.5e-20 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs300703 0.515 rs300694 chr2:182277 G/T cg21211680 chr2:198530 NA -0.89 -10.36 -0.54 2.36e-21 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21382589 chr2:8785969 NA 0.49 6.32 0.36 1.08e-9 Fibrinogen levels; CESC cis rs2832077 0.943 rs11701777 chr21:30155828 T/C cg03476357 chr21:30257390 N6AMT1 -0.5 -5.51 -0.32 8.42e-8 Cognitive test performance; CESC trans rs1814175 0.669 rs11040455 chr11:49669829 G/C cg15704280 chr7:45808275 SEPT13 -0.82 -11.49 -0.58 4.55e-25 Height; CESC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.94 12.52 0.61 1.44e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2228479 0.867 rs76885005 chr16:89966668 A/G cg06558623 chr16:89946397 TCF25 1.06 9.08 0.49 2.48e-17 Skin colour saturation; CESC cis rs2404602 0.716 rs7169394 chr15:76913274 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.49 -0.32 9.6e-8 Blood metabolite levels; CESC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg02725872 chr8:58115012 NA -0.42 -5.98 -0.34 7.21e-9 Developmental language disorder (linguistic errors); CESC cis rs1371867 0.846 rs1692006 chr8:101252462 C/T cg06002616 chr8:101225028 SPAG1 0.33 5.3 0.31 2.48e-7 Atrioventricular conduction; CESC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.62 -7.97 -0.44 4.59e-14 Tonsillectomy; CESC cis rs3540 0.597 rs1978150 chr15:91037041 A/G cg10434728 chr15:90938212 IQGAP1 -0.42 -7.53 -0.42 8.14e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1003719 0.680 rs2835668 chr21:38580151 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.22 -0.45 9.27e-15 Eye color traits; CESC cis rs7246657 0.943 rs2045908 chr19:37979768 C/G cg23950597 chr19:37808831 NA -0.59 -6.63 -0.38 1.86e-10 Coronary artery calcification; CESC cis rs4253772 0.591 rs6008546 chr22:46686377 T/G cg10541313 chr22:46663664 TTC38 0.63 5.6 0.33 5.27e-8 LDL cholesterol;Cholesterol, total; CESC cis rs3092073 0.624 rs3848719 chr20:44596545 G/A cg00125455 chr20:44574271 PCIF1 0.39 6.15 0.35 2.81e-9 Intelligence (multi-trait analysis); CESC cis rs4727963 0.846 rs1581561 chr7:122705273 C/G cg03640110 chr7:122635026 TAS2R16 -0.37 -5.7 -0.33 3.11e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs8077889 0.957 rs17742929 chr17:41891437 C/T cg26893861 chr17:41843967 DUSP3 0.77 8.82 0.48 1.53e-16 Triglycerides; CESC cis rs34779708 0.931 rs4934724 chr10:35393669 C/T cg03585969 chr10:35415529 CREM 0.77 10.1 0.53 1.62e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs4481887 0.927 rs6666903 chr1:248465582 T/A cg00666640 chr1:248458726 OR2T12 0.32 5.46 0.32 1.07e-7 Common traits (Other); CESC cis rs7927592 0.913 rs2282563 chr11:68333200 C/T cg20283391 chr11:68216788 NA -0.61 -7.36 -0.41 2.26e-12 Total body bone mineral density; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11522767 chr6:157342961 ARID1B 0.47 6.25 0.36 1.67e-9 Systemic lupus erythematosus; CESC cis rs644799 0.540 rs10831419 chr11:95478037 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.65 9.05 0.49 3.06e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9303401 0.659 rs34170300 chr17:56789905 G/C cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC trans rs4349753 0.640 rs72804498 chr5:144083143 T/C cg22407458 chr6:35109121 TCP11 0.5 6.31 0.36 1.18e-9 Photic sneeze reflex; CESC cis rs2040771 0.804 rs1091013 chr22:19248587 C/T cg02655711 chr22:19163373 SLC25A1 0.42 6.08 0.35 4.1e-9 Metabolite levels (small molecules and protein measures); CESC cis rs9611565 0.681 rs5751094 chr22:41803279 C/T cg17376030 chr22:41985996 PMM1 -0.59 -6.24 -0.36 1.69e-9 Vitiligo; CESC cis rs965469 1.000 rs3310 chr20:3237232 C/T cg25506879 chr20:3388711 C20orf194 -0.6 -6.45 -0.37 5.14e-10 IFN-related cytopenia; CESC cis rs1371867 0.817 rs1788208 chr8:101312515 T/C cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.1e-11 Atrioventricular conduction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07874155 chr5:138089656 CTNNA1 -0.55 -6.21 -0.36 2.08e-9 Gut microbiome composition (summer); CESC cis rs7089973 0.604 rs11819372 chr10:116594934 A/G cg03647239 chr10:116582469 FAM160B1 0.44 5.76 0.33 2.28e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25240468 chr2:62115958 CCT4 0.54 6.17 0.35 2.53e-9 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg16339924 chr4:17578868 LAP3 0.65 8.27 0.45 6.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg18350739 chr11:68623251 NA -0.45 -6.96 -0.39 2.67e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2228479 0.867 rs12919804 chr16:89945369 G/A cg14709524 chr16:89940631 TCF25 0.74 5.75 0.33 2.43e-8 Skin colour saturation; CESC cis rs2991971 0.810 rs12738318 chr1:45929589 A/G cg24296786 chr1:45957014 TESK2 -0.61 -8.72 -0.47 3.1e-16 High light scatter reticulocyte count; CESC cis rs748404 0.697 rs531910 chr15:43560607 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.84 0.43 1.08e-13 Lung cancer; CESC cis rs4805272 0.539 rs11883172 chr19:29318536 C/T cg12756686 chr19:29218302 NA 0.51 5.94 0.34 8.77e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23374814 chr5:72292757 FCHO2 -0.65 -7.31 -0.41 3.07e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01010380 chr5:32313163 MTMR12 0.56 6.48 0.37 4.56e-10 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg23758822 chr17:41437982 NA 1.04 15.74 0.7 7.3e-40 Menopause (age at onset); CESC cis rs3850699 0.666 rs7905481 chr10:104476292 T/C cg04362960 chr10:104952993 NT5C2 0.47 5.41 0.32 1.42e-7 Prostate cancer; CESC cis rs4891159 0.790 rs1056714 chr18:74149526 A/G cg24786174 chr18:74118243 ZNF516 -0.73 -11.02 -0.56 1.72e-23 Longevity; CESC cis rs2932538 0.922 rs6671645 chr1:113129128 A/G cg22162597 chr1:113214053 CAPZA1 0.47 6.35 0.36 9.56e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg17372223 chr3:52568218 NT5DC2 0.42 6.41 0.37 6.55e-10 Bipolar disorder; CESC cis rs7605827 0.930 rs11675805 chr2:15578274 C/T cg19274914 chr2:15703543 NA 0.34 6.07 0.35 4.38e-9 Educational attainment (years of education); CESC cis rs10876993 0.928 rs7136269 chr12:58075937 G/A cg18357645 chr12:58087776 OS9 0.63 10.35 0.54 2.58e-21 Celiac disease or Rheumatoid arthritis; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg02405619 chr13:111906946 ARHGEF7 0.48 6.88 0.39 4.37e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg07677032 chr17:61819896 STRADA 0.44 5.88 0.34 1.2e-8 Prudent dietary pattern; CESC cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg05639522 chr1:247681581 NA 0.46 6.02 0.35 5.84e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg11494091 chr17:61959527 GH2 0.75 13.12 0.63 1.23e-30 Prudent dietary pattern; CESC cis rs2204008 0.805 rs2874289 chr12:38258420 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.7 0.38 1.27e-10 Bladder cancer; CESC cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg11952622 chr19:58962976 ZNF324B 0.52 6.94 0.39 3.06e-11 Uric acid clearance; CESC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg04025307 chr7:1156635 C7orf50 0.58 9.91 0.52 6.75e-20 Longevity;Endometriosis; CESC cis rs6582630 0.572 rs7315897 chr12:38449081 C/T cg26384229 chr12:38710491 ALG10B -0.44 -5.94 -0.34 9.08e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg07157834 chr1:205819609 PM20D1 -0.57 -8.74 -0.47 2.81e-16 Monocyte percentage of white cells; CESC cis rs3820068 0.553 rs7545782 chr1:15955227 G/C cg13390004 chr1:15929781 NA 0.37 5.9 0.34 1.12e-8 Systolic blood pressure; CESC cis rs796364 0.951 rs12996313 chr2:200997916 C/T cg23649088 chr2:200775458 C2orf69 -0.52 -5.09 -0.3 6.95e-7 Schizophrenia; CESC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg09699651 chr6:150184138 LRP11 0.41 5.14 0.3 5.44e-7 Lung cancer; CESC cis rs208520 1.000 rs208523 chr6:66954195 G/C cg07460842 chr6:66804631 NA -0.9 -10.34 -0.54 2.79e-21 Exhaled nitric oxide output; CESC cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg27478167 chr7:817139 HEATR2 -0.47 -5.61 -0.33 5.18e-8 Cerebrospinal P-tau181p levels; CESC cis rs6964587 0.967 rs10246036 chr7:91558523 G/A cg17063962 chr7:91808500 NA -0.59 -7.88 -0.44 8.67e-14 Breast cancer; CESC cis rs10887741 0.690 rs4934357 chr10:89439533 G/A cg13926569 chr10:89418898 PAPSS2 0.4 6.08 0.35 4.2e-9 Exercise (leisure time); CESC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs4704187 0.687 rs7711762 chr5:74461675 C/T cg03227963 chr5:74354835 NA 0.29 5.32 0.31 2.25e-7 Response to amphetamines; CESC trans rs4942242 0.663 rs34595450 chr13:44221245 A/G cg19169023 chr15:41853346 TYRO3 -0.61 -7.78 -0.43 1.67e-13 Response to tocilizumab in rheumatoid arthritis; CESC cis rs367615 0.680 rs816542 chr5:108982624 A/G cg17395555 chr5:108820864 NA 0.38 5.39 0.31 1.58e-7 Colorectal cancer (SNP x SNP interaction); CESC cis rs7116495 0.881 rs6592451 chr11:71674937 G/A cg26138937 chr11:71823887 C11orf51 -0.79 -6.51 -0.37 3.77e-10 Severe influenza A (H1N1) infection; CESC cis rs12681288 0.823 rs2701903 chr8:1004029 A/G cg15309053 chr8:964076 NA -0.35 -6.18 -0.36 2.38e-9 Schizophrenia; CESC cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg23711669 chr6:146136114 FBXO30 -0.93 -12.2 -0.6 1.79e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg12311346 chr5:56204834 C5orf35 -0.64 -8.78 -0.47 2.01e-16 Initial pursuit acceleration; CESC cis rs9611565 0.592 rs5996039 chr22:41981957 A/G cg17376030 chr22:41985996 PMM1 0.49 5.49 0.32 9.33e-8 Vitiligo; CESC cis rs2011503 0.941 rs6511027 chr19:19391851 C/T cg11584989 chr19:19387371 SF4 0.58 6.98 0.39 2.42e-11 Bipolar disorder; CESC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg13777783 chr17:79615861 NA -0.37 -6.16 -0.35 2.72e-9 Eye color traits; CESC cis rs12476592 0.543 rs1446569 chr2:63818314 C/G cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC cis rs12530845 0.561 rs73725182 chr7:135291001 C/T cg23117316 chr7:135346802 PL-5283 -0.5 -5.59 -0.32 5.59e-8 Red blood cell traits; CESC cis rs2066819 1.000 rs77447765 chr12:56690662 G/A cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs11809207 0.523 rs2783707 chr1:26504196 C/G cg00147160 chr1:26503991 CNKSR1 0.28 5.23 0.31 3.42e-7 Height; CESC cis rs2304069 1.000 rs7737689 chr5:149396159 C/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.75 9.38 0.5 3.04e-18 HIV-1 control; CESC cis rs6674176 0.597 rs3762422 chr1:44400532 T/A cg12908607 chr1:44402522 ARTN -0.51 -8.0 -0.44 3.92e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs8141529 0.702 rs5762870 chr22:29261159 C/T cg02153584 chr22:29168773 CCDC117 0.58 7.78 0.43 1.61e-13 Lymphocyte counts; CESC cis rs9486719 1.000 rs4343922 chr6:96876903 C/T cg06623918 chr6:96969491 KIAA0776 0.89 10.0 0.52 3.56e-20 Migraine;Coronary artery disease; CESC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg07424592 chr7:64974309 NA -0.39 -5.69 -0.33 3.43e-8 Calcium levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13639345 chr22:39052718 CBY1;LOC646851 0.46 6.24 0.36 1.75e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7561273 0.586 rs11896092 chr2:24317827 G/A cg01493198 chr2:24299560 SF3B14 0.42 5.13 0.3 5.69e-7 Quantitative traits; CESC cis rs55788414 0.932 rs12103303 chr16:81181497 A/G cg06400318 chr16:81190750 PKD1L2 -0.6 -7.07 -0.4 1.38e-11 Left ventricular obstructive tract defect (maternal effect); CESC trans rs9325144 0.560 rs10785562 chr12:38637419 A/C cg23762105 chr12:34175262 ALG10 0.48 6.36 0.36 8.78e-10 Morning vs. evening chronotype; CESC trans rs10411161 0.702 rs7251755 chr19:52388948 G/A cg22319618 chr22:45562946 NUP50 -0.75 -7.56 -0.42 6.61e-13 Breast cancer; CESC cis rs16867321 0.627 rs1009998 chr2:181579313 G/C cg23363182 chr2:181467187 NA 0.43 6.25 0.36 1.6e-9 Obesity; CESC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -5.18 -0.3 4.41e-7 Developmental language disorder (linguistic errors); CESC cis rs6748734 1.000 rs11898716 chr2:241828311 A/G cg07537917 chr2:241836409 C2orf54 -0.24 -5.04 -0.3 8.46e-7 Urinary metabolites; CESC trans rs875971 0.964 rs778721 chr7:65845397 C/G cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.69e-9 Aortic root size; CESC cis rs7659604 0.702 rs6815790 chr4:122695385 A/C cg19748678 chr4:122722346 EXOSC9 0.7 9.12 0.49 1.92e-17 Type 2 diabetes; CESC cis rs2777491 1.000 rs316610 chr15:41752852 C/T cg02330683 chr15:41787940 ITPKA 0.47 7.04 0.4 1.64e-11 Ulcerative colitis; CESC cis rs3892630 0.612 rs10413282 chr19:33182751 A/G cg22980127 chr19:33182716 NUDT19 1.06 14.82 0.67 1.33e-36 Red blood cell traits; CESC cis rs7789940 0.904 rs6948661 chr7:75961647 T/C cg10167463 chr7:75959203 YWHAG -0.56 -7.09 -0.4 1.23e-11 Multiple sclerosis; CESC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.31 -5.88 -0.34 1.23e-8 Bipolar disorder; CESC cis rs6500395 0.962 rs13331902 chr16:48644989 A/G cg04672837 chr16:48644449 N4BP1 0.47 5.57 0.32 6.4e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7512552 0.839 rs6662108 chr1:150420541 G/T cg15654264 chr1:150340011 RPRD2 0.39 5.14 0.3 5.23e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg02018176 chr4:1364513 KIAA1530 0.61 7.8 0.43 1.42e-13 Longevity; CESC cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg00033643 chr7:134001901 SLC35B4 0.44 5.6 0.33 5.33e-8 Mean platelet volume; CESC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg24550644 chr17:30846204 MYO1D -0.39 -5.61 -0.33 5e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00380150 chr22:31885763 EIF4ENIF1 0.55 6.06 0.35 4.66e-9 Gut microbiome composition (summer); CESC cis rs9303542 0.559 rs62066693 chr17:46617530 G/C cg04904318 chr17:46607828 HOXB1 -0.58 -5.67 -0.33 3.64e-8 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs11711311 0.824 rs35952547 chr3:113352501 G/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.63 8.13 0.45 1.68e-14 IgG glycosylation; CESC cis rs4589502 0.800 rs4147433 chr15:67201152 G/A cg12317470 chr15:67143691 NA -0.73 -8.7 -0.47 3.56e-16 Lung cancer (smoking interaction); CESC cis rs1355223 0.545 rs7123029 chr11:34874815 G/A cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.59 -0.38 2.37e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7665939 0.929 rs13353755 chr4:190100646 T/C cg09826759 chr4:190284978 NA -0.72 -7.55 -0.42 6.96e-13 Amyotrophic lateral sclerosis; CESC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.42 0.64 1.1e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7178572 0.633 rs11857860 chr15:77839761 T/C cg22256960 chr15:77711686 NA -0.52 -6.62 -0.38 2e-10 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17250947 chr3:42642016 NKTR 0.53 6.33 0.36 1.05e-9 Gut microbiome composition (summer); CESC cis rs4588572 0.644 rs1159930 chr5:77768943 C/T cg11547950 chr5:77652471 NA 0.45 6.33 0.36 1.03e-9 Triglycerides; CESC cis rs6582630 0.519 rs8189549 chr12:38245752 A/G cg13010199 chr12:38710504 ALG10B 0.51 6.3 0.36 1.24e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs2346177 0.542 rs6757564 chr2:46702619 G/C cg02822958 chr2:46747628 ATP6V1E2 0.45 5.75 0.33 2.45e-8 HDL cholesterol; CESC cis rs9291683 0.609 rs4622999 chr4:10003395 C/G cg11266682 chr4:10021025 SLC2A9 0.65 12.98 0.62 3.63e-30 Bone mineral density; CESC cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg05283184 chr6:79620031 NA -0.43 -6.61 -0.38 2.06e-10 Intelligence (multi-trait analysis); CESC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg23161317 chr6:28129485 ZNF389 0.37 5.15 0.3 5.04e-7 Cardiac Troponin-T levels; CESC cis rs7607369 0.536 rs4674345 chr2:219671598 A/G cg02176678 chr2:219576539 TTLL4 -0.34 -5.95 -0.34 8.27e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs9911578 1.000 rs304296 chr17:56834229 G/T cg12560992 chr17:57184187 TRIM37 0.92 15.29 0.68 2.77e-38 Intelligence (multi-trait analysis); CESC cis rs1975974 0.511 rs112710683 chr17:21741695 C/A cg18423549 chr17:21743878 NA -0.7 -10.07 -0.53 2.12e-20 Psoriasis; CESC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg18758796 chr5:131593413 PDLIM4 0.38 5.17 0.3 4.69e-7 Breast cancer; CESC cis rs1048238 0.545 rs848199 chr1:16292742 C/T cg22431228 chr1:16359049 CLCNKA 0.37 6.39 0.37 7.54e-10 Systolic blood pressure; CESC cis rs2304069 0.837 rs10041451 chr5:149385197 A/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.9 11.48 0.58 4.92e-25 HIV-1 control; CESC cis rs6582630 0.519 rs2387812 chr12:38381480 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.73 0.33 2.68e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9611565 0.681 rs6002372 chr22:41801299 A/T cg17376030 chr22:41985996 PMM1 -0.68 -7.12 -0.4 1.02e-11 Vitiligo; CESC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg07507251 chr3:52567010 NT5DC2 0.4 6.96 0.39 2.7e-11 Bipolar disorder; CESC cis rs68170813 0.559 rs17429146 chr7:106964281 A/G cg02696742 chr7:106810147 HBP1 -0.55 -5.17 -0.3 4.51e-7 Coronary artery disease; CESC cis rs3818285 0.504 rs4917547 chr10:111652285 T/C cg00817464 chr10:111662876 XPNPEP1 -0.55 -7.61 -0.42 4.84e-13 Superior crus of antihelix expression; CESC trans rs3780486 0.846 rs10813948 chr9:33121570 G/A cg04842962 chr6:43655489 MRPS18A 1.0 19.07 0.76 1.21e-51 IgG glycosylation; CESC cis rs9303401 0.659 rs35564417 chr17:56718286 G/T cg10487724 chr17:56770010 TEX14;RAD51C 1.04 13.0 0.62 3.27e-30 Cognitive test performance; CESC cis rs2408955 0.521 rs1476607 chr12:48524804 A/G cg24011408 chr12:48396354 COL2A1 -0.51 -7.49 -0.42 1.01e-12 Glycated hemoglobin levels; CESC cis rs7617480 0.544 rs6442129 chr3:48735256 T/C cg07636037 chr3:49044803 WDR6 0.76 9.8 0.52 1.47e-19 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg19705215 chr14:61747501 TMEM30B 0.43 6.05 0.35 4.79e-9 Bronchopulmonary dysplasia; CESC cis rs3008870 1.000 rs3008894 chr1:67377739 A/G cg02640540 chr1:67518911 SLC35D1 0.5 5.29 0.31 2.55e-7 Lymphocyte percentage of white cells; CESC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg03452623 chr4:187889614 NA -0.89 -15.18 -0.68 7.11e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs1707322 1.000 rs11211237 chr1:46447329 G/C cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg24073613 chr1:210424721 NA 0.5 6.42 0.37 6.32e-10 Breast cancer;Type 2 diabetes; CESC cis rs11764590 0.694 rs10241537 chr7:2083358 A/G cg21782813 chr7:2030301 MAD1L1 -0.39 -5.3 -0.31 2.48e-7 Neuroticism; CESC cis rs55788414 0.860 rs1806875 chr16:81184069 T/C cg06400318 chr16:81190750 PKD1L2 -0.6 -6.82 -0.39 6.19e-11 Left ventricular obstructive tract defect (maternal effect); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05092304 chr11:107047494 NA -0.57 -6.98 -0.39 2.36e-11 Gut microbiome composition (summer); CESC cis rs7560272 0.501 rs12713793 chr2:73956114 T/C cg20560298 chr2:73613845 ALMS1 0.43 5.89 0.34 1.14e-8 Schizophrenia; CESC cis rs1005277 0.522 rs289647 chr10:37968278 A/G cg25427524 chr10:38739819 LOC399744 -0.59 -8.61 -0.47 6.69e-16 Extrinsic epigenetic age acceleration; CESC cis rs10242455 0.557 rs59672032 chr7:99058697 T/C cg18809830 chr7:99032528 PTCD1 -0.59 -5.17 -0.3 4.59e-7 Blood metabolite levels; CESC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg00149659 chr3:10157352 C3orf10 0.75 9.42 0.5 2.25e-18 Alzheimer's disease; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg15783703 chr7:70209588 AUTS2 -0.44 -6.15 -0.35 2.91e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg24110177 chr3:50126178 RBM5 0.54 7.47 0.42 1.2e-12 Body mass index; CESC cis rs4974559 0.501 rs1732115 chr4:1244416 C/T cg02980000 chr4:1222292 CTBP1 0.76 7.84 0.43 1.12e-13 Systolic blood pressure; CESC cis rs35110281 0.666 rs2236665 chr21:45108987 C/A cg04455712 chr21:45112962 RRP1B 0.49 7.59 0.42 5.37e-13 Mean corpuscular volume; CESC cis rs9488822 0.636 rs6937104 chr6:116375302 A/G cg15226275 chr6:116381976 FRK 0.26 6.55 0.37 2.95e-10 Cholesterol, total;LDL cholesterol; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04579211 chr15:41221939 DLL4 0.43 6.01 0.35 6.24e-9 Systemic lupus erythematosus; CESC cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg05347473 chr6:146136440 FBXO30 0.59 7.63 0.42 4.24e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs11098499 0.820 rs2389885 chr4:120533931 C/T cg25214090 chr10:38739885 LOC399744 0.66 8.57 0.47 8.55e-16 Corneal astigmatism; CESC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.52 6.18 0.35 2.47e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg16145915 chr7:1198662 ZFAND2A -0.47 -6.6 -0.38 2.2e-10 Longevity;Endometriosis; CESC cis rs9896933 0.732 rs590886 chr17:80767350 A/G cg15369054 chr17:80825471 TBCD -0.45 -5.11 -0.3 6.18e-7 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs453301 0.571 rs2929453 chr8:9084341 A/G cg17143192 chr8:8559678 CLDN23 -0.47 -5.82 -0.34 1.67e-8 Joint mobility (Beighton score); CESC cis rs9916302 0.904 rs34363096 chr17:37594294 G/A cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 4.03e-10 Glomerular filtration rate (creatinine); CESC cis rs11711311 1.000 rs11711311 chr3:113430599 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.32 0.54 3.4e-21 IgG glycosylation; CESC cis rs4664308 0.935 rs4520993 chr2:160937673 G/A cg03641300 chr2:160917029 PLA2R1 -0.67 -9.84 -0.52 1.11e-19 Idiopathic membranous nephropathy; CESC cis rs4072980 0.545 rs12120737 chr1:38422544 C/T cg17077180 chr1:38461687 NA 0.41 5.8 0.34 1.93e-8 Coronary artery disease; CESC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs55788414 0.932 rs28583467 chr16:81186428 G/C cg06400318 chr16:81190750 PKD1L2 -0.58 -6.44 -0.37 5.6e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.12 0.53 1.43e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07294870 chr20:44044586 PIGT -0.6 -7.24 -0.41 4.89e-12 Gut microbiome composition (summer); CESC cis rs7635838 0.819 rs7637414 chr3:11522228 C/G cg00170343 chr3:11313890 ATG7 0.41 5.55 0.32 6.97e-8 HDL cholesterol; CESC cis rs16867321 0.590 rs1528453 chr2:181581272 A/G cg23363182 chr2:181467187 NA 0.44 6.48 0.37 4.5e-10 Obesity; CESC cis rs8133932 0.555 rs374331 chr21:47338218 A/G cg14185626 chr21:47401492 COL6A1 -0.45 -5.09 -0.3 6.84e-7 Schizophrenia; CESC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -6.06 -0.35 4.64e-9 Mood instability; CESC cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg05585544 chr11:47624801 NA -0.46 -6.81 -0.39 6.58e-11 Subjective well-being; CESC trans rs9929218 1.000 rs12921546 chr16:68780069 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -9.67 -0.51 3.83e-19 Colorectal cancer; CESC cis rs1042058 0.565 rs650110 chr10:30753132 A/G cg18806716 chr10:30721971 MAP3K8 -0.54 -8.15 -0.45 1.46e-14 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs7618501 0.521 rs6774354 chr3:49961780 G/A cg24110177 chr3:50126178 RBM5 -0.55 -7.72 -0.43 2.38e-13 Intelligence (multi-trait analysis); CESC cis rs17376456 0.877 rs17083455 chr5:93446380 A/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.66 0.33 4.02e-8 Diabetic retinopathy; CESC cis rs2603127 0.768 rs9833239 chr3:108478131 G/C cg03329597 chr3:108125523 MYH15 0.6 5.35 0.31 1.91e-7 Hemostatic factors and hematological phenotypes; CESC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg22920501 chr2:26401640 FAM59B -0.79 -9.3 -0.5 5.61e-18 Gut microbiome composition (summer); CESC trans rs61931739 0.613 rs61927728 chr12:33667690 T/C cg26384229 chr12:38710491 ALG10B -0.45 -6.34 -0.36 9.58e-10 Morning vs. evening chronotype; CESC cis rs11098499 0.954 rs3890049 chr4:120326283 T/A cg09307838 chr4:120376055 NA 0.92 12.77 0.62 2.08e-29 Corneal astigmatism; CESC cis rs7605827 0.930 rs11893253 chr2:15606618 A/G cg19274914 chr2:15703543 NA 0.33 5.96 0.34 8.22e-9 Educational attainment (years of education); CESC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg04166393 chr7:2884313 GNA12 0.59 8.08 0.44 2.29e-14 Height; CESC cis rs11741688 0.557 rs6898923 chr5:178330559 C/T cg20935368 chr5:178288625 ZNF354B 0.34 5.4 0.32 1.45e-7 Sleep duration; CESC cis rs703842 0.963 rs2069506 chr12:58142854 C/A cg00677455 chr12:58241039 CTDSP2 0.52 6.68 0.38 1.41e-10 Multiple sclerosis; CESC cis rs10779751 1.000 rs12032364 chr1:11286872 G/T cg08854313 chr1:11322531 MTOR 0.79 10.52 0.54 7.46e-22 Body mass index; CESC cis rs1707322 0.826 rs10890349 chr1:46249955 T/C cg05343316 chr1:45956843 TESK2 0.47 5.7 0.33 3.21e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs360071 0.528 rs360093 chr1:226064745 G/T cg17950169 chr1:226067900 TMEM63A 0.35 5.35 0.31 1.9e-7 Response to radiotherapy in prostate cancer (toxicity, rectal bleeding); CESC cis rs763014 0.931 rs710925 chr16:633354 G/A cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg11965913 chr1:205819406 PM20D1 0.92 17.0 0.72 2.46e-44 Menarche (age at onset); CESC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg17724175 chr1:150552817 MCL1 0.46 7.55 0.42 7.08e-13 Tonsillectomy; CESC cis rs317689 0.680 rs315140 chr12:69790780 A/T cg14784868 chr12:69753453 YEATS4 0.58 6.69 0.38 1.29e-10 Response to diuretic therapy; CESC cis rs2439831 1.000 rs28666488 chr15:43741090 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.56 0.54 5.55e-22 Lung cancer in ever smokers; CESC cis rs2243480 1.000 rs73142166 chr7:65375832 A/G cg13147721 chr7:65941812 NA -0.88 -8.09 -0.45 2.17e-14 Diabetic kidney disease; CESC cis rs6429082 0.633 rs1416473 chr1:235563259 C/T cg26050004 chr1:235667680 B3GALNT2 -0.54 -6.77 -0.38 8.47e-11 Adiposity; CESC cis rs7617480 0.616 rs9873227 chr3:48773108 G/C cg07636037 chr3:49044803 WDR6 0.79 10.66 0.55 2.61e-22 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.76e-28 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.955 rs7685268 chr4:120162188 G/A cg09307838 chr4:120376055 NA 0.86 11.44 0.58 6.63e-25 Corneal astigmatism; CESC cis rs6964587 1.000 rs7805077 chr7:91644553 A/G cg17063962 chr7:91808500 NA 0.56 7.76 0.43 1.79e-13 Breast cancer; CESC cis rs10870270 0.956 rs7894 chr10:133769482 G/C cg26149184 chr10:133730230 NA 0.37 5.1 0.3 6.63e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg20307385 chr11:47447363 PSMC3 -0.62 -7.5 -0.42 9.54e-13 Subjective well-being; CESC cis rs5758659 0.622 rs6519298 chr22:42364997 C/T cg04733989 chr22:42467013 NAGA 0.42 5.55 0.32 6.94e-8 Cognitive function; CESC cis rs1018836 0.663 rs4735190 chr8:91509601 A/G cg16814680 chr8:91681699 NA -0.58 -7.68 -0.43 3e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs478222 0.930 rs510107 chr2:25319471 G/A cg01884057 chr2:25150051 NA -0.3 -5.15 -0.3 5.02e-7 Type 1 diabetes; CESC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg24642844 chr7:1081250 C7orf50 -0.76 -9.45 -0.5 1.94e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4853012 0.793 rs6723185 chr2:74344884 T/A cg01017244 chr2:74357527 NA 0.7 10.07 0.53 2.09e-20 Gestational age at birth (maternal effect); CESC cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg05283184 chr6:79620031 NA -0.44 -6.88 -0.39 4.39e-11 Intelligence (multi-trait analysis); CESC cis rs929596 0.793 rs13009407 chr2:234652347 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.55 -5.58 -0.32 6.03e-8 Total bilirubin levels in HIV-1 infection; CESC cis rs600231 0.542 rs10896009 chr11:65246054 A/G cg17120908 chr11:65337727 SSSCA1 0.55 5.32 0.31 2.19e-7 Bone mineral density; CESC cis rs6933660 0.720 rs6913515 chr6:151753470 G/C cg02564969 chr6:151773285 C6orf211;RMND1 0.59 8.01 0.44 3.54e-14 Menarche (age at onset); CESC cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.33 5.53 0.32 7.8e-8 Hemoglobin concentration; CESC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg17372223 chr3:52568218 NT5DC2 0.34 5.2 0.3 3.98e-7 Electroencephalogram traits; CESC cis rs6963495 0.818 rs73192141 chr7:105201129 T/G cg02135003 chr7:105160482 PUS7 -0.48 -5.55 -0.32 7.01e-8 Bipolar disorder (body mass index interaction); CESC cis rs7520050 0.966 rs61102033 chr1:46382441 G/T cg03146154 chr1:46216737 IPP -0.48 -6.27 -0.36 1.48e-9 Red blood cell count;Reticulocyte count; CESC cis rs3857536 0.813 rs6903411 chr6:66938288 T/C cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC trans rs2502399 0.689 rs4945490 chr6:113493299 C/T cg00285294 chr7:1089767 C7orf50 -0.33 -6.2 -0.36 2.2e-9 Plasma clusterin levels; CESC cis rs9399401 0.710 rs10484733 chr6:142710988 C/G cg04461802 chr6:142623433 GPR126 0.42 6.05 0.35 4.81e-9 Chronic obstructive pulmonary disease; CESC cis rs1707322 0.963 rs1768815 chr1:46528603 G/A cg06784218 chr1:46089804 CCDC17 -0.33 -5.57 -0.32 6.38e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs4335177 0.963 rs7858774 chr9:109359345 A/C cg12580783 chr12:49362475 WNT10B -0.32 -6.0 -0.35 6.3e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs9611565 0.605 rs202638 chr22:41855458 A/G cg03806693 chr22:41940476 POLR3H 0.81 9.57 0.51 7.93e-19 Vitiligo; CESC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg11764359 chr7:65958608 NA 0.79 9.47 0.5 1.64e-18 Aortic root size; CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.43 -5.39 -0.31 1.59e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08393828 chr14:102228221 PPP2R5C -0.45 -6.38 -0.36 7.83e-10 Gambling; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02488887 chr5:176830915 F12 -0.47 -6.97 -0.39 2.5e-11 Gambling; CESC cis rs6088580 0.602 rs6059840 chr20:33030405 G/A cg06115741 chr20:33292138 TP53INP2 0.48 6.14 0.35 3.02e-9 Glomerular filtration rate (creatinine); CESC cis rs7527798 0.592 rs11118337 chr1:207852693 G/C cg21110645 chr1:207815933 NA -0.33 -5.76 -0.33 2.39e-8 Erythrocyte sedimentation rate; CESC cis rs13102973 0.899 rs7442212 chr4:135899800 A/G cg14419869 chr4:135874104 NA -0.34 -5.06 -0.3 8.02e-7 Subjective well-being; CESC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg18240062 chr17:79603768 NPLOC4 0.54 7.05 0.4 1.55e-11 Eye color traits; CESC cis rs4148883 0.603 rs1893883 chr4:100124716 C/G cg12011299 chr4:100065546 ADH4 0.5 7.24 0.41 4.84e-12 Alcohol dependence; CESC trans rs2273788 1.000 rs2273788 chr9:114348617 C/T cg02412050 chr6:35995429 MAPK14 -0.63 -6.36 -0.36 8.96e-10 Monocyte count; CESC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg27266027 chr21:40555129 PSMG1 0.45 5.07 0.3 7.64e-7 Cognitive function; CESC cis rs1707322 1.000 rs785467 chr1:46521559 A/T cg06784218 chr1:46089804 CCDC17 -0.35 -5.96 -0.34 7.81e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1348850 0.914 rs3813259 chr2:178257214 G/A cg23306229 chr2:178417860 TTC30B 0.63 7.77 0.43 1.69e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3749237 0.557 rs7631908 chr3:49425707 T/G cg03060546 chr3:49711283 APEH 0.75 11.31 0.57 1.91e-24 Resting heart rate; CESC cis rs7336332 0.598 rs9581852 chr13:28013748 A/G cg22138327 chr13:27999177 GTF3A 0.62 5.66 0.33 3.95e-8 Weight; CESC cis rs8141529 0.748 rs5762882 chr22:29290680 C/A cg02153584 chr22:29168773 CCDC117 0.59 7.62 0.42 4.46e-13 Lymphocyte counts; CESC trans rs853679 0.546 rs200953 chr6:27837267 T/C cg06606381 chr12:133084897 FBRSL1 -0.8 -7.56 -0.42 6.58e-13 Depression; CESC cis rs7903847 0.642 rs10786339 chr10:99153076 A/G cg20016023 chr10:99160130 RRP12 -0.3 -5.12 -0.3 5.99e-7 Granulocyte percentage of myeloid white cells; CESC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg07701084 chr6:150067640 NUP43 0.48 6.7 0.38 1.26e-10 Lung cancer; CESC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.52 0.37 3.64e-10 Depression; CESC trans rs9307551 0.817 rs11098766 chr4:80500420 G/T cg02747103 chr19:603718 HCN2 -0.42 -6.55 -0.37 2.98e-10 Refractive error; CESC cis rs9287719 0.639 rs2357649 chr2:10696788 C/T cg00105475 chr2:10696890 NA -0.45 -6.75 -0.38 9.11e-11 Prostate cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11114063 chr6:147524085 STXBP5 -0.51 -6.14 -0.35 2.99e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03773226 chr17:37353657 CACNB1 -0.54 -6.43 -0.37 6.02e-10 Gut microbiome composition (summer); CESC cis rs7927592 0.913 rs66752716 chr11:68273626 C/T cg20283391 chr11:68216788 NA -0.62 -7.54 -0.42 7.45e-13 Total body bone mineral density; CESC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.55 0.37 3.03e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2243480 1.000 rs4718315 chr7:65648541 T/C cg13147721 chr7:65941812 NA 0.97 9.16 0.49 1.47e-17 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00332212 chr4:48908696 OCIAD2 0.6 6.32 0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs72781680 1.000 rs56104215 chr2:24133590 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs1003719 0.708 rs8126491 chr21:38551219 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.13 -0.45 1.66e-14 Eye color traits; CESC cis rs3126085 0.935 rs74127901 chr1:152195579 G/A cg03465714 chr1:152285911 FLG 0.45 5.11 0.3 6.27e-7 Atopic dermatitis; CESC cis rs4919694 1.000 rs11191525 chr10:104793435 G/C cg04362960 chr10:104952993 NT5C2 0.77 6.69 0.38 1.34e-10 Arsenic metabolism; CESC cis rs892961 0.932 rs35657663 chr17:75412482 T/C cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs6570726 0.791 rs9403730 chr6:145907233 C/T cg23711669 chr6:146136114 FBXO30 0.92 13.73 0.64 9.24e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs9818941 0.824 rs2712320 chr3:157770116 A/G cg08654915 chr3:157813417 NA -0.46 -7.39 -0.41 1.96e-12 Height; CESC cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.47 0.46 1.72e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9908102 0.710 rs8071445 chr17:12914480 A/G cg26162695 chr17:12921313 ELAC2 0.51 5.55 0.32 7.03e-8 Schizophrenia; CESC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg23754390 chr11:835074 CD151 0.32 5.69 0.33 3.32e-8 Mean platelet volume; CESC cis rs7605827 0.930 rs11676198 chr2:15603097 G/A cg19274914 chr2:15703543 NA 0.35 6.28 0.36 1.39e-9 Educational attainment (years of education); CESC cis rs10751667 0.666 rs4074234 chr11:977715 C/G cg06064525 chr11:970664 AP2A2 -0.47 -9.12 -0.49 1.9e-17 Alzheimer's disease (late onset); CESC cis rs2204008 0.714 rs11520135 chr12:38114863 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.72 0.55 1.6400000000000001e-22 Bladder cancer; CESC cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 8.83 0.48 1.43e-16 Hip circumference adjusted for BMI; CESC cis rs6540556 0.769 rs909710 chr1:209930694 A/G cg05527609 chr1:210001259 C1orf107 0.65 7.67 0.43 3.35e-13 Red blood cell count; CESC cis rs854765 0.547 rs2955370 chr17:17966945 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.88 -0.48 1.06e-16 Total body bone mineral density; CESC cis rs6500602 0.653 rs4786488 chr16:4442527 C/T cg08645402 chr16:4508243 NA 0.4 5.67 0.33 3.72e-8 Schizophrenia; CESC cis rs7259376 0.936 rs1865073 chr19:22554980 T/G cg02657401 chr19:22469223 NA -0.26 -5.07 -0.3 7.61e-7 Menopause (age at onset); CESC cis rs959260 0.858 rs2053156 chr17:73378440 G/T cg20590849 chr17:73267439 MIF4GD -0.57 -6.67 -0.38 1.53e-10 Systemic lupus erythematosus; CESC cis rs8114671 0.528 rs6119542 chr20:33484545 G/T cg06115741 chr20:33292138 TP53INP2 0.48 5.79 0.34 1.97e-8 Height; CESC cis rs7809950 0.678 rs62483640 chr7:106900214 T/G cg23024343 chr7:107201750 COG5 -0.54 -6.81 -0.39 6.51e-11 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17784606 chr1:1190558 UBE2J2 -0.57 -6.43 -0.37 6.01e-10 Gut microbiome composition (summer); CESC cis rs12701220 0.522 rs12701455 chr7:1055409 A/G cg20821713 chr7:1055600 C7orf50 -0.47 -6.13 -0.35 3.23e-9 Bronchopulmonary dysplasia; CESC cis rs3617 0.625 rs2535633 chr3:52859630 C/G cg11645453 chr3:52864694 ITIH4 -0.25 -5.05 -0.3 8.43e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg16325326 chr1:53192061 ZYG11B 0.61 9.09 0.49 2.38e-17 Monocyte count; CESC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg20243544 chr17:37824526 PNMT -0.45 -5.57 -0.32 6.16e-8 Glomerular filtration rate (creatinine); CESC cis rs17431357 0.609 rs73225229 chr12:120962627 T/A cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg20135002 chr11:47629003 NA -0.4 -5.1 -0.3 6.41e-7 Subjective well-being; CESC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg02038168 chr22:39784481 NA -0.61 -7.93 -0.44 6.21e-14 Intelligence (multi-trait analysis); CESC cis rs17376456 0.825 rs55947981 chr5:93278104 G/T cg21475434 chr5:93447410 FAM172A 0.77 6.39 0.37 7.61e-10 Diabetic retinopathy; CESC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg12311346 chr5:56204834 C5orf35 -0.77 -9.27 -0.49 6.75e-18 Initial pursuit acceleration; CESC cis rs7772486 0.790 rs10223507 chr6:146285204 C/A cg23711669 chr6:146136114 FBXO30 -0.83 -11.54 -0.58 3.22e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs7937682 0.881 rs4936678 chr11:111625085 C/T cg09085632 chr11:111637200 PPP2R1B 1.1 12.18 0.6 2.08e-27 Primary sclerosing cholangitis; CESC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg17376030 chr22:41985996 PMM1 -0.79 -8.37 -0.46 3.43e-15 Vitiligo; CESC cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg01579765 chr21:45077557 HSF2BP -0.49 -7.96 -0.44 5.21e-14 Mean corpuscular volume; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23946709 chr14:23527317 CDH24 0.52 6.87 0.39 4.44e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs637571 0.607 rs589253 chr11:65693080 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 5.78 0.33 2.07e-8 Eosinophil percentage of white cells; CESC cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.05 0.3 8.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.908 rs6948654 chr7:12418546 T/A cg06484146 chr7:12443880 VWDE -0.74 -8.98 -0.48 5.25e-17 Coronary artery disease; CESC cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg02297831 chr4:17616191 MED28 0.62 7.91 0.44 7.23e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2991971 0.810 rs6657237 chr1:45920108 A/T cg05343316 chr1:45956843 TESK2 0.57 8.04 0.44 2.93e-14 High light scatter reticulocyte count; CESC cis rs2249625 0.874 rs1819063 chr6:72908180 A/G cg18830697 chr6:72922368 RIMS1 -0.37 -5.22 -0.31 3.69e-7 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05657488 chr16:23689988 PLK1 0.68 7.81 0.43 1.35e-13 Gut microbiome composition (summer); CESC cis rs7590368 0.673 rs72779425 chr2:10940601 C/G cg15705551 chr2:10952987 PDIA6 0.54 5.2 0.3 4.09e-7 Educational attainment (years of education); CESC cis rs6662572 0.737 rs4423055 chr1:46259980 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.06 -0.3 7.83e-7 Blood protein levels; CESC cis rs9325144 0.600 rs34138871 chr12:38735261 A/G cg26384229 chr12:38710491 ALG10B 0.56 8.04 0.44 3.07e-14 Morning vs. evening chronotype; CESC cis rs3780486 1.000 rs3780480 chr9:33163486 G/T cg13443165 chr9:33130375 B4GALT1 0.42 5.61 0.33 5.2100000000000003e-08 IgG glycosylation; CESC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.21 0.3 3.78e-7 Menopause (age at onset); CESC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg25204440 chr1:209979598 IRF6 -0.42 -5.58 -0.32 5.82e-8 Monobrow; CESC cis rs7818688 0.697 rs77402106 chr8:95970484 C/T cg16049864 chr8:95962084 TP53INP1 0.57 5.64 0.33 4.29e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg00149659 chr3:10157352 C3orf10 0.74 8.94 0.48 6.91e-17 Alzheimer's disease; CESC cis rs919433 0.926 rs12618567 chr2:198148191 A/T cg03934865 chr2:198174659 NA -0.42 -6.02 -0.35 5.86e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2243480 1.000 rs2243480 chr7:65599196 C/T cg13147721 chr7:65941812 NA -0.84 -7.86 -0.43 9.9e-14 Diabetic kidney disease; CESC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg04025307 chr7:1156635 C7orf50 0.46 7.15 0.4 8.62e-12 Longevity;Endometriosis; CESC cis rs57506017 0.585 rs3800843 chr7:12264297 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.37e-7 Neuroticism; CESC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -6.78 -0.38 7.92e-11 Bipolar disorder; CESC cis rs7100689 0.556 rs3120976 chr10:82025682 C/A cg00277334 chr10:82204260 NA -0.5 -6.4 -0.37 7.14e-10 Post bronchodilator FEV1; CESC cis rs9818941 0.826 rs2670286 chr3:157638213 C/G cg08654915 chr3:157813417 NA 0.43 6.99 0.39 2.3e-11 Height; CESC cis rs11958404 0.932 rs72816552 chr5:157422376 G/A cg05962755 chr5:157440814 NA 0.63 6.86 0.39 4.87e-11 IgG glycosylation; CESC cis rs910316 0.712 rs175074 chr14:75504454 G/A cg08847533 chr14:75593920 NEK9 -0.91 -16.32 -0.71 6.26e-42 Height; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15459342 chr1:228296991 MRPL55 0.48 6.4 0.37 7.06e-10 Systemic lupus erythematosus; CESC cis rs826838 0.935 rs4583043 chr12:38645147 T/G cg26384229 chr12:38710491 ALG10B 0.82 14.3 0.66 8.87e-35 Heart rate; CESC cis rs6835098 0.924 rs2332669 chr4:174163398 G/A cg08422745 chr4:174089978 GALNT7 -0.69 -9.85 -0.52 1.07e-19 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg06456125 chr7:65229604 NA 0.46 6.0 0.35 6.31e-9 Calcium levels; CESC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC trans rs2236231 0.914 rs10138094 chr14:68037895 A/C cg02340083 chr1:50882006 NA 0.4 6.15 0.35 2.81e-9 Plasma kynurenine levels in major depressive disorder; CESC trans rs2235573 0.551 rs139891 chr22:38387914 G/T cg19894588 chr14:64061835 NA 0.57 7.45 0.42 1.31e-12 Glioblastoma;Glioma; CESC cis rs9894429 0.538 rs9747080 chr17:79606704 A/G cg18240062 chr17:79603768 NPLOC4 0.69 9.09 0.49 2.43e-17 Eye color traits; CESC cis rs2425143 1.000 rs6060572 chr20:34294015 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.63 -0.42 4.14e-13 Blood protein levels; CESC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg22800045 chr5:56110881 MAP3K1 0.82 10.18 0.53 9.04e-21 Initial pursuit acceleration; CESC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg03647317 chr4:187891568 NA -0.38 -5.73 -0.33 2.75e-8 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19349143 chr22:47189686 TBC1D22A 0.45 6.3 0.36 1.23e-9 Fibrinogen levels; CESC cis rs2250402 0.510 rs7535 chr15:40328575 G/C cg16127683 chr15:40268777 EIF2AK4 -0.63 -5.67 -0.33 3.82e-8 Corneal curvature; CESC cis rs9399135 0.967 rs11756988 chr6:135347595 A/G cg24558204 chr6:135376177 HBS1L 0.52 7.29 0.41 3.48e-12 Red blood cell count; CESC cis rs3105593 1.000 rs1986074 chr15:50857452 T/C cg08437265 chr15:50716283 USP8 0.4 5.11 0.3 6.15e-7 QT interval; CESC cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg03433033 chr1:76189801 ACADM -0.52 -5.63 -0.33 4.58e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg27170947 chr2:26402098 FAM59B 0.76 8.48 0.46 1.63e-15 Gut microbiome composition (summer); CESC cis rs17376456 0.825 rs17372649 chr5:93126096 C/G cg21475434 chr5:93447410 FAM172A 0.83 7.39 0.41 1.91e-12 Diabetic retinopathy; CESC cis rs55794721 0.509 rs6699896 chr1:25762902 A/T cg03538708 chr1:25844672 NA -0.41 -6.16 -0.35 2.64e-9 Plateletcrit;Mean corpuscular volume; CESC cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg16545954 chr1:2118288 C1orf86 0.36 7.06 0.4 1.46e-11 Height; CESC cis rs2204008 0.744 rs11514071 chr12:38392076 C/T cg13010199 chr12:38710504 ALG10B 0.47 5.89 0.34 1.15e-8 Bladder cancer; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg12498409 chr7:40174463 C7orf10;C7orf11 0.46 6.19 0.36 2.26e-9 Thyroid stimulating hormone; CESC cis rs10927875 0.541 rs1739844 chr1:16343322 T/C cg22431228 chr1:16359049 CLCNKA -0.52 -9.9 -0.52 7.22e-20 Dilated cardiomyopathy; CESC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg17724175 chr1:150552817 MCL1 0.38 5.9 0.34 1.11e-8 Melanoma; CESC cis rs2404602 0.679 rs12908421 chr15:76881794 T/G cg22467129 chr15:76604101 ETFA -0.36 -5.33 -0.31 2.11e-7 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06135480 chr16:85644718 KIAA0182 0.53 6.39 0.37 7.58e-10 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20088969 chr10:74032886 DDIT4 -0.4 -6.31 -0.36 1.15e-9 Gambling; CESC cis rs2832077 1.000 rs12329875 chr21:30137796 C/T cg03476357 chr21:30257390 N6AMT1 -0.5 -5.46 -0.32 1.07e-7 Cognitive test performance; CESC cis rs698833 0.848 rs696596 chr2:44718058 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.88 0.34 1.23e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs2243480 1.000 rs35046236 chr7:65408613 T/C cg18252515 chr7:66147081 NA -1.06 -9.79 -0.52 1.67e-19 Diabetic kidney disease; CESC cis rs13418410 0.539 rs1545399 chr2:33843801 A/G cg04131969 chr2:33951647 MYADML -0.65 -8.03 -0.44 3.12e-14 Non-response to antidepressants and depression; CESC trans rs2727020 0.894 rs11040333 chr11:49346332 G/A cg03929089 chr4:120376271 NA -0.62 -7.04 -0.4 1.66e-11 Coronary artery disease; CESC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg18876405 chr7:65276391 NA -0.55 -6.32 -0.36 1.1e-9 Aortic root size; CESC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.98 0.34 7.35e-9 Tonsillectomy; CESC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.55 0.46 1.01e-15 Menopause (age at onset); CESC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg02711726 chr17:80685570 FN3KRP -0.43 -5.69 -0.33 3.41e-8 Glycated hemoglobin levels; CESC cis rs2204008 0.774 rs11520273 chr12:38354075 A/T cg26384229 chr12:38710491 ALG10B 0.69 10.42 0.54 1.6e-21 Bladder cancer; CESC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg14500267 chr11:67383377 NA 0.33 5.36 0.31 1.83e-7 Mean corpuscular volume; CESC cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg06697600 chr4:7070879 GRPEL1 -0.48 -7.23 -0.41 5.24e-12 Monocyte percentage of white cells; CESC cis rs920590 0.758 rs1826420 chr8:19664878 G/T cg01411142 chr8:19674711 INTS10 0.51 5.89 0.34 1.17e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg08564027 chr20:61660810 NA 0.9 15.44 0.69 8.75e-39 Prostate cancer (SNP x SNP interaction); CESC trans rs9858542 1.000 rs9858542 chr3:49701983 A/G cg21659725 chr3:3221576 CRBN 0.52 6.38 0.36 7.9e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2070997 0.607 rs2855191 chr9:133708441 C/T cg11464064 chr9:133710261 ABL1 -0.68 -7.64 -0.42 4e-13 Response to amphetamines; CESC cis rs7918232 1.000 rs7918232 chr10:27369162 A/G cg14442939 chr10:27389572 ANKRD26 0.57 5.98 0.34 7.19e-9 Breast cancer; CESC cis rs4237845 0.761 rs11172378 chr12:58298161 C/T cg02175503 chr12:58329896 NA 0.62 7.83 0.43 1.18e-13 Intelligence (multi-trait analysis); CESC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg25566285 chr7:158114605 PTPRN2 0.49 7.94 0.44 5.95e-14 Calcium levels; CESC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg01416388 chr22:39784598 NA -0.62 -7.88 -0.44 8.63e-14 Intelligence (multi-trait analysis); CESC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg17376030 chr22:41985996 PMM1 -0.78 -8.33 -0.46 4.43e-15 Crohn's disease;Inflammatory bowel disease; CESC cis rs4948102 1.000 rs4948102 chr7:56097265 C/G cg09872392 chr7:56161020 PHKG1 -0.43 -6.47 -0.37 4.79e-10 Plasma homocysteine levels (post-methionine load test); CESC trans rs11764590 0.950 rs11514731 chr7:2051503 C/G cg11693508 chr17:37793320 STARD3 0.68 6.87 0.39 4.65e-11 Neuroticism; CESC cis rs2644899 0.859 rs2545755 chr19:41293162 T/G cg24958765 chr19:41283667 RAB4B -0.57 -6.44 -0.37 5.56e-10 Post bronchodilator FEV1/FVC ratio; CESC cis rs7259376 0.936 rs1865074 chr19:22554949 G/C cg02657401 chr19:22469223 NA -0.26 -5.07 -0.3 7.61e-7 Menopause (age at onset); CESC trans rs17685 0.753 rs13240404 chr7:75675719 C/T cg19862616 chr7:65841803 NCRNA00174 -0.84 -12.47 -0.61 2.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs12410462 0.681 rs78978081 chr1:227571619 G/A cg23173402 chr1:227635558 NA 0.68 5.73 0.33 2.78e-8 Major depressive disorder; CESC cis rs7116495 1.000 rs1939245 chr11:71742532 C/T cg26138937 chr11:71823887 C11orf51 -0.83 -6.72 -0.38 1.14e-10 Severe influenza A (H1N1) infection; CESC cis rs11677370 0.603 rs10178523 chr2:3854169 G/A cg17052675 chr2:3827356 NA -0.45 -5.71 -0.33 2.95e-8 Type 2 diabetes; CESC trans rs35110281 0.774 rs162344 chr21:44954522 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 6.34 0.36 9.67e-10 Mean corpuscular volume; CESC cis rs208520 0.690 rs2208442 chr6:66867004 T/C cg07460842 chr6:66804631 NA -1.0 -13.45 -0.64 8.77e-32 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04381898 chr2:219082190 ARPC2 0.57 6.7 0.38 1.26e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg06481639 chr22:41940642 POLR3H -0.63 -6.6 -0.38 2.22e-10 Vitiligo; CESC cis rs7927592 0.717 rs7126451 chr11:68257386 A/G cg01657329 chr11:68192670 LRP5 0.4 5.36 0.31 1.77e-7 Total body bone mineral density; CESC trans rs875971 0.862 rs12698521 chr7:65939489 T/C cg26939375 chr7:64535504 NA 0.47 6.09 0.35 4.06e-9 Aortic root size; CESC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg07648498 chr16:89883185 FANCA 0.44 5.42 0.32 1.32e-7 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25424237 chr12:123718121 C12orf65 -0.51 -6.64 -0.38 1.78e-10 Fibrinogen levels; CESC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg26441486 chr22:50317300 CRELD2 0.43 5.12 0.3 5.81e-7 Schizophrenia; CESC cis rs11155671 0.530 rs2342769 chr6:150216507 T/C cg09699651 chr6:150184138 LRP11 0.54 7.5 0.42 9.91e-13 Testicular germ cell tumor; CESC cis rs1801251 0.727 rs6437071 chr2:233568793 G/A cg08000102 chr2:233561755 GIGYF2 0.65 9.43 0.5 2.23e-18 Coronary artery disease; CESC cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg22764044 chr5:178986830 RUFY1 0.44 6.25 0.36 1.62e-9 Lung cancer; CESC cis rs9287719 0.967 rs7587231 chr2:10740093 C/T cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs733592 0.723 rs10875766 chr12:48593580 G/C cg24011408 chr12:48396354 COL2A1 0.44 6.73 0.38 1.05e-10 Plateletcrit; CESC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.13 0.3 5.72e-7 Menopause (age at onset); CESC cis rs10129255 0.536 rs10139058 chr14:107141916 C/T cg07958169 chr14:107095056 NA -0.46 -6.92 -0.39 3.33e-11 Kawasaki disease; CESC cis rs11083475 0.557 rs2368519 chr19:39259241 C/T cg20002381 chr19:39279703 LGALS7B -0.24 -5.19 -0.3 4.12e-7 Heart rate; CESC cis rs13102973 0.965 rs4469136 chr4:135850051 C/T cg14419869 chr4:135874104 NA 0.33 5.19 0.3 4.29e-7 Subjective well-being; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27612744 chr5:16465883 ZNF622 -0.44 -6.63 -0.38 1.85e-10 Gambling; CESC cis rs4704187 0.687 rs10035303 chr5:74505495 A/C cg03227963 chr5:74354835 NA 0.28 5.18 0.3 4.33e-7 Response to amphetamines; CESC cis rs7607369 0.559 rs4674341 chr2:219659911 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -7.1 -0.4 1.18e-11 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs7923452 0.507 rs103441 chr10:30778184 C/T cg25182066 chr10:30743637 MAP3K8 -0.46 -6.21 -0.36 2.04e-9 Itch intensity from mosquito bite; CESC trans rs9858542 0.953 rs6779524 chr3:49450449 C/T cg21659725 chr3:3221576 CRBN -0.54 -6.42 -0.37 6.43e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6546550 0.935 rs6546551 chr2:70073703 C/T cg02498382 chr2:70120550 SNRNP27 -0.38 -6.49 -0.37 4.2e-10 Prevalent atrial fibrillation; CESC cis rs10883723 0.773 rs11191303 chr10:104255158 T/C cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs2708240 0.967 rs2708239 chr7:147575961 G/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.23e-8 QT interval (drug interaction); CESC cis rs1707322 0.686 rs2991979 chr1:46055858 A/G cg03146154 chr1:46216737 IPP -0.77 -10.4 -0.54 1.77e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05168378 chr7:100425517 EPHB4 0.58 6.92 0.39 3.38e-11 Gut microbiome composition (summer); CESC cis rs1865721 0.958 rs72977878 chr18:73193037 T/G cg26385618 chr18:73139727 C18orf62 -0.5 -7.4 -0.41 1.83e-12 Intelligence; CESC cis rs6500602 0.634 rs2270365 chr16:4526758 G/A cg08645402 chr16:4508243 NA 0.55 8.69 0.47 3.72e-16 Schizophrenia; CESC cis rs4423214 1.000 rs11606631 chr11:71164121 C/A cg05163923 chr11:71159392 DHCR7 0.76 10.16 0.53 1.05e-20 Vitamin D levels; CESC cis rs9309473 0.607 rs11686504 chr2:73579812 T/C cg20560298 chr2:73613845 ALMS1 -0.45 -6.09 -0.35 3.94e-9 Metabolite levels; CESC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.28 -0.31 2.67e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs453301 0.719 rs34004903 chr8:8892604 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -6.27 -0.36 1.43e-9 Joint mobility (Beighton score); CESC cis rs56116382 0.604 rs9858428 chr3:49877585 G/T cg00383909 chr3:49044727 WDR6 0.82 5.31 0.31 2.3e-7 Intelligence (multi-trait analysis);High light scatter reticulocyte count; CESC cis rs2273669 0.667 rs75942063 chr6:109352545 G/A cg05315195 chr6:109294784 ARMC2 -0.67 -6.06 -0.35 4.74e-9 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23421970 chr18:33552539 C18orf21 -0.47 -6.04 -0.35 5.09e-9 Fibrinogen levels; CESC trans rs35146811 0.624 rs1727134 chr7:99813672 T/C cg13215871 chr17:75784724 NA -0.35 -6.39 -0.37 7.48e-10 Coronary artery disease; CESC cis rs644799 1.000 rs534497 chr11:95562868 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.06 0.49 2.9e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7044106 0.762 rs12003646 chr9:123470621 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 8.54 0.46 1.05e-15 Hip circumference adjusted for BMI; CESC cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.47 7.82 0.43 1.26e-13 Hemoglobin concentration; CESC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs2066819 1.000 rs808919 chr12:56647911 C/G cg26316697 chr12:56727976 PAN2 -0.67 -6.46 -0.37 4.99e-10 Psoriasis vulgaris; CESC cis rs7208859 0.673 rs73277964 chr17:29179201 A/T cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs17021463 0.902 rs2865352 chr4:95253263 A/G cg11021082 chr4:95130006 SMARCAD1 -0.58 -9.07 -0.49 2.75e-17 Testicular germ cell tumor; CESC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg04166393 chr7:2884313 GNA12 0.58 7.58 0.42 5.85e-13 Height; CESC cis rs2479724 0.846 rs1536702 chr6:41869950 T/A cg17623882 chr6:41773611 USP49 -0.41 -5.68 -0.33 3.53e-8 Menarche (age at onset); CESC cis rs7666738 0.791 rs10022061 chr4:98926821 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs524023 1.000 rs10792441 chr11:64360629 C/T cg07220939 chr11:64358617 SLC22A12 -0.36 -5.58 -0.32 5.95e-8 Urate levels in obese individuals; CESC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg19592336 chr6:28129416 ZNF389 0.62 8.11 0.45 1.84e-14 Depression; CESC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg03517284 chr6:25882590 NA 0.42 5.68 0.33 3.46e-8 Intelligence (multi-trait analysis); CESC cis rs7267979 1.000 rs2500432 chr20:25290512 A/C cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.76 0.7 6.3e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs2204008 0.515 rs11495471 chr12:38027178 G/A cg26384229 chr12:38710491 ALG10B 0.75 10.72 0.55 1.61e-22 Bladder cancer; CESC cis rs6835098 0.961 rs2078475 chr4:174098226 A/C cg08422745 chr4:174089978 GALNT7 0.73 9.33 0.5 4.31e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs9916302 0.904 rs2338800 chr17:37498149 C/G cg20243544 chr17:37824526 PNMT -0.48 -6.13 -0.35 3.15e-9 Glomerular filtration rate (creatinine); CESC cis rs1538970 0.847 rs781230 chr1:45880751 C/T cg05343316 chr1:45956843 TESK2 -0.79 -11.27 -0.57 2.43e-24 Platelet count; CESC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.94 12.55 0.61 1.16e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs61931739 0.534 rs1844526 chr12:34102780 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.18 0.45 1.17e-14 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.5 0.46 1.36e-15 Colonoscopy-negative controls vs population controls; CESC cis rs13191362 0.935 rs34268859 chr6:162934731 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.69 5.97 0.34 7.56e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg12963246 chr6:28129442 ZNF389 0.54 7.12 0.4 1.02e-11 Depression; CESC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg23161317 chr6:28129485 ZNF389 0.49 6.2 0.36 2.14e-9 Parkinson's disease; CESC cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg10523679 chr1:76189770 ACADM -0.68 -6.82 -0.39 6.01e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs919433 0.890 rs979020 chr2:198169749 T/C cg03934865 chr2:198174659 NA -0.46 -6.85 -0.39 5.2e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2191566 0.881 rs1996408 chr19:44532732 G/A cg20607764 chr19:44506953 ZNF230 -0.65 -8.55 -0.47 9.84e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs2011503 1.000 rs1557723 chr19:19443033 A/G cg11584989 chr19:19387371 SF4 -0.63 -7.42 -0.41 1.55e-12 Bipolar disorder; CESC cis rs3785574 0.743 rs2727334 chr17:61969063 A/T cg06873352 chr17:61820015 STRADA 0.48 6.88 0.39 4.26e-11 Height; CESC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg23172400 chr8:95962367 TP53INP1 -0.5 -10.43 -0.54 1.43e-21 Type 2 diabetes; CESC cis rs6460942 1.000 rs6460938 chr7:12406808 T/G cg20607287 chr7:12443886 VWDE -0.8 -9.07 -0.49 2.85e-17 Coronary artery disease; CESC cis rs7208859 0.623 rs59447372 chr17:29057585 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg18402987 chr7:1209562 NA 0.64 6.6 0.38 2.28e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7914558 0.966 rs943035 chr10:104839152 T/C cg04362960 chr10:104952993 NT5C2 0.47 6.12 0.35 3.36e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg03396347 chr1:1875803 NA -0.43 -6.69 -0.38 1.29e-10 Body mass index; CESC trans rs6794880 0.673 rs75690303 chr3:84419526 A/G cg03554283 chr8:76319451 NA 0.57 6.07 0.35 4.44e-9 Body mass index (joint analysis main effects and smoking interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg11742103 chr11:62369870 EML3;MTA2 0.65 9.89 0.52 7.57e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs57506017 0.540 rs1435525 chr7:12262717 T/C cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.51e-7 Neuroticism; CESC cis rs9715521 0.775 rs62301198 chr4:59848776 C/T cg11281224 chr4:60001000 NA -0.5 -6.55 -0.37 2.9e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4253772 0.637 rs9627295 chr22:46650100 C/T cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.48 5.11 0.3 6.16e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7772486 0.743 rs2092262 chr6:146037105 C/T cg05347473 chr6:146136440 FBXO30 -0.48 -6.45 -0.37 5.16e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4555082 0.830 rs3803319 chr14:105752458 G/A cg13114125 chr14:105738426 BRF1 -0.86 -10.51 -0.54 8.21e-22 Mean platelet volume;Platelet distribution width; CESC cis rs2213920 0.516 rs71505546 chr9:118158372 G/A cg13918206 chr9:118159781 DEC1 -0.69 -5.52 -0.32 8.06e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CESC cis rs1348850 0.540 rs10172355 chr2:178443225 A/G cg22681709 chr2:178499509 PDE11A -0.44 -5.14 -0.3 5.3e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg18350739 chr11:68623251 NA -0.45 -6.9 -0.39 3.91e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6062302 0.522 rs2236503 chr20:62224595 G/A cg09650180 chr20:62225654 GMEB2 -0.81 -9.23 -0.49 9e-18 Glioblastoma; CESC cis rs6459788 0.692 rs10807645 chr7:157258979 T/C cg06271696 chr7:157225062 NA 0.36 5.83 0.34 1.65e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg21138405 chr5:131827807 IRF1 0.54 9.24 0.49 8.12e-18 Asthma (sex interaction); CESC cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg21395723 chr22:39101663 GTPBP1 -0.41 -5.07 -0.3 7.51e-7 Menopause (age at onset); CESC cis rs4704187 0.687 rs4627970 chr5:74528776 G/A cg03227963 chr5:74354835 NA 0.28 5.08 0.3 7.28e-7 Response to amphetamines; CESC cis rs1005277 0.522 rs9417256 chr10:37976990 A/G cg00409905 chr10:38381863 ZNF37A -0.51 -7.12 -0.4 1.04e-11 Extrinsic epigenetic age acceleration; CESC cis rs6089584 0.566 rs6061964 chr20:60607536 G/A cg24733560 chr20:60626293 TAF4 0.49 7.28 0.41 3.85e-12 Body mass index; CESC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg03576123 chr11:487126 PTDSS2 -1.12 -11.1 -0.56 9.13e-24 Body mass index; CESC cis rs10654220 1 rs10654220 chr12:123703422 A/AGTT cg00376283 chr12:123451042 ABCB9 0.61 6.37 0.36 8.43e-10 Platelet count; CESC cis rs3126085 0.935 rs6681433 chr1:152277396 T/C cg03465714 chr1:152285911 FLG 0.5 5.77 0.33 2.2e-8 Atopic dermatitis; CESC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC trans rs7839040 0.698 rs10110295 chr8:82921482 C/T cg14472086 chr9:107730925 NA -0.48 -6.53 -0.37 3.31e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs9796 0.870 rs2927061 chr15:41302219 A/G cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.21 -0.36 2.05e-9 Menopause (age at onset); CESC cis rs12142240 0.698 rs6667861 chr1:46815749 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs4925386 0.959 rs6121989 chr20:60916713 A/T cg24112000 chr20:60950667 NA 0.51 7.39 0.41 1.94e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.82 10.01 0.52 3.34e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10927875 0.688 rs2009371 chr1:16348083 A/T cg21385522 chr1:16154831 NA 0.59 6.95 0.39 2.89e-11 Dilated cardiomyopathy; CESC cis rs1577917 1.000 rs10944161 chr6:86630376 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.33 2.14e-8 Response to antipsychotic treatment; CESC cis rs116095464 0.558 rs7703803 chr5:292311 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.17 0.3 4.68e-7 Breast cancer; CESC cis rs11958404 0.615 rs10058832 chr5:157431866 T/A cg05962755 chr5:157440814 NA 0.4 5.74 0.33 2.54e-8 IgG glycosylation; CESC cis rs9914988 0.887 rs9895625 chr17:27108516 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs6741892 0.536 rs7590835 chr2:38893950 A/G cg08308459 chr2:38893161 GALM 0.52 6.59 0.38 2.34e-10 5-HTT brain serotonin transporter levels; CESC cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg03709012 chr19:19516395 GATAD2A 0.99 15.75 0.7 6.65e-40 Tonsillectomy; CESC cis rs7188697 0.885 rs246194 chr16:58573901 G/A cg02549819 chr16:58548995 SETD6 -0.42 -5.3 -0.31 2.46e-7 QT interval; CESC cis rs4664293 0.967 rs10803758 chr2:160548219 T/C cg08347373 chr2:160653686 CD302 -0.31 -5.12 -0.3 5.88e-7 Monocyte percentage of white cells; CESC cis rs3750965 0.959 rs3376 chr11:68856680 G/A cg01403660 chr11:68851641 TPCN2 0.4 5.21 0.3 3.74e-7 Hair color; CESC cis rs62064224 0.765 rs62065463 chr17:30732405 G/T cg12855166 chr17:30846586 MYO1D 0.4 5.16 0.3 4.76e-7 Schizophrenia; CESC cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg25554036 chr4:6271136 WFS1 0.54 8.64 0.47 5.27e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs61931739 0.534 rs11052983 chr12:34045787 C/A cg26384229 chr12:38710491 ALG10B 0.53 7.22 0.41 5.44e-12 Morning vs. evening chronotype; CESC cis rs926392 0.666 rs912179 chr20:37710775 G/A cg16355469 chr20:37678765 NA 0.53 6.05 0.35 4.87e-9 Dialysis-related mortality; CESC cis rs763121 0.853 rs4821816 chr22:39113134 G/A cg21395723 chr22:39101663 GTPBP1 0.51 7.11 0.4 1.08e-11 Menopause (age at onset); CESC cis rs7084402 0.967 rs1649039 chr10:60330041 C/T cg07615347 chr10:60278583 BICC1 0.59 9.29 0.5 5.85e-18 Refractive error; CESC cis rs2576037 0.583 rs9960463 chr18:44522808 T/A cg19077165 chr18:44547161 KATNAL2 -0.63 -9.5 -0.5 1.35e-18 Personality dimensions; CESC cis rs4077515 1.000 rs10870077 chr9:139263891 C/G cg14169450 chr9:139327907 INPP5E 0.35 5.08 0.3 7.21e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs9911578 0.967 rs11079368 chr17:57086473 C/T cg12560992 chr17:57184187 TRIM37 -1.01 -17.88 -0.74 1.96e-47 Intelligence (multi-trait analysis); CESC cis rs11602339 1 rs11602339 chr11:47761471 C/T cg18512352 chr11:47633146 NA -0.6 -9.5 -0.5 1.32e-18 Body mass index; CESC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.34 0.5 3.98e-18 Menopause (age at onset); CESC cis rs7107174 1.000 rs2511185 chr11:77982496 C/A cg02023728 chr11:77925099 USP35 0.39 5.77 0.33 2.17e-8 Testicular germ cell tumor; CESC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg14703610 chr5:56206110 C5orf35 -0.51 -6.51 -0.37 3.8e-10 Coronary artery disease; CESC cis rs116095464 0.614 rs4371799 chr5:268192 C/A cg22857025 chr5:266934 NA -1.28 -18.52 -0.75 1.03e-49 Breast cancer; CESC cis rs12541635 0.701 rs2029878 chr8:107025283 A/G cg10147462 chr8:107024639 NA 0.4 6.25 0.36 1.61e-9 Age of smoking initiation; CESC cis rs3762637 0.941 rs60222267 chr3:122179632 G/T cg24169773 chr3:122142474 KPNA1 -0.54 -6.33 -0.36 1.04e-9 LDL cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06264183 chr20:35202306 TGIF2 -0.58 -6.65 -0.38 1.69e-10 Gut microbiome composition (summer); CESC cis rs9527 0.590 rs10509766 chr10:104926334 T/C cg04362960 chr10:104952993 NT5C2 0.42 5.25 0.31 3.11e-7 Arsenic metabolism; CESC cis rs10883723 0.810 rs2296586 chr10:104245575 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.48 5.83 0.34 1.64e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg08027265 chr7:2291960 NA 0.35 5.4 0.31 1.49e-7 Bipolar disorder and schizophrenia; CESC cis rs6840258 1.000 rs56395939 chr4:87963633 T/G cg08197287 chr4:87952173 AFF1 -0.4 -5.52 -0.32 8.06e-8 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs2072732 0.821 rs12034573 chr1:2948020 C/T cg15211996 chr1:2936768 ACTRT2 0.29 5.12 0.3 5.88e-7 Plateletcrit; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09092161 chr9:130639739 AK1 -0.45 -6.09 -0.35 3.91e-9 Gut microbiota (bacterial taxa); CESC cis rs644799 0.896 rs4430471 chr11:95646774 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.44 5.31 0.31 2.32e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs8092503 1.000 rs8092503 chr18:52479487 A/G cg12377874 chr18:52495404 RAB27B 0.38 6.27 0.36 1.46e-9 Childhood body mass index; CESC cis rs2404602 0.684 rs11072602 chr15:76873467 T/C cg23625390 chr15:77176239 SCAPER -0.43 -5.85 -0.34 1.44e-8 Blood metabolite levels; CESC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg22920501 chr2:26401640 FAM59B -0.7 -8.39 -0.46 2.85e-15 Gut microbiome composition (summer); CESC cis rs2777491 0.507 rs34040639 chr15:41760807 A/G cg18705301 chr15:41695430 NDUFAF1 -1.01 -15.93 -0.7 1.59e-40 Ulcerative colitis; CESC cis rs933688 0.532 rs13164949 chr5:90538489 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.44 -5.13 -0.3 5.63e-7 Smoking behavior; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg00930706 chr16:88752925 MGC23284;SNAI3 0.46 6.5 0.37 4.01e-10 Thyroid stimulating hormone; CESC cis rs7927771 0.542 rs7122217 chr11:47777920 G/C cg05585544 chr11:47624801 NA -0.32 -5.11 -0.3 6.09e-7 Subjective well-being; CESC cis rs6540559 0.673 rs17015361 chr1:210018901 C/G cg21951975 chr1:209979733 IRF6 0.55 6.64 0.38 1.75e-10 Cleft lip with or without cleft palate; CESC cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.2 0.3 3.94e-7 Electroencephalogram traits; CESC cis rs55788414 0.932 rs4365300 chr16:81184460 C/T cg06400318 chr16:81190750 PKD1L2 -0.6 -6.82 -0.39 6.19e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs6582630 0.593 rs7299329 chr12:38447943 G/C cg13010199 chr12:38710504 ALG10B 0.46 6.0 0.35 6.56e-9 Drug-induced liver injury (flucloxacillin); CESC trans rs11098499 0.863 rs3775854 chr4:120471971 C/T cg25214090 chr10:38739885 LOC399744 0.67 9.15 0.49 1.55e-17 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27535044 chr8:82633568 ZFAND1 0.54 6.82 0.39 6.2e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02098460 chr2:114196058 CBWD2;LOC440839 0.59 6.96 0.39 2.63e-11 Gut microbiome composition (summer); CESC cis rs7937682 1.000 rs11608149 chr11:111535102 G/A cg09085632 chr11:111637200 PPP2R1B 1.04 15.08 0.68 1.63e-37 Primary sclerosing cholangitis; CESC cis rs8062405 0.721 rs151303 chr16:28492510 C/A cg05966235 chr16:28915196 ATP2A1 0.37 5.2 0.3 4.04e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg04369109 chr6:150039330 LATS1 -0.37 -5.07 -0.3 7.56e-7 Lung cancer; CESC cis rs7584330 0.554 rs10173100 chr2:238433040 A/G cg14458575 chr2:238380390 NA 0.49 5.42 0.32 1.35e-7 Prostate cancer; CESC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg10018233 chr7:150070692 REPIN1 0.41 5.66 0.33 3.85e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs11608355 0.545 rs4766604 chr12:109892179 T/C cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs9929218 1.000 rs28549017 chr16:68758828 G/C cg02972257 chr16:68554789 NA 0.55 6.4 0.37 6.95e-10 Colorectal cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18684905 chr19:1822532 REXO1 0.42 6.18 0.35 2.42e-9 Gambling; CESC cis rs765787 0.530 rs12905246 chr15:45500841 C/T cg24006582 chr15:45444508 DUOX1 0.52 6.37 0.36 8.32e-10 Uric acid levels; CESC cis rs2243480 1.000 rs73142121 chr7:65311206 C/T cg12463550 chr7:65579703 CRCP 0.68 5.61 0.33 5.08e-8 Diabetic kidney disease; CESC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg08499158 chr17:42289980 UBTF -0.52 -6.56 -0.37 2.85e-10 Total body bone mineral density; CESC cis rs9399135 0.967 rs2327580 chr6:135364417 A/C cg24558204 chr6:135376177 HBS1L 0.52 7.14 0.4 9.15e-12 Red blood cell count; CESC cis rs35110281 0.805 rs2838318 chr21:44991825 G/A cg21573476 chr21:45109991 RRP1B -0.38 -5.34 -0.31 1.99e-7 Mean corpuscular volume; CESC cis rs6695640 0.854 rs1555660 chr1:17731117 T/C cg01904812 chr1:17746340 RCC2 0.35 5.19 0.3 4.15e-7 Mean platelet volume; CESC cis rs59698941 0.943 rs73259116 chr5:132218461 A/G cg02081065 chr5:132209139 LEAP2 -0.52 -5.11 -0.3 6.08e-7 Apolipoprotein A-IV levels; CESC cis rs7703051 0.901 rs5744672 chr5:74877803 T/C cg03227963 chr5:74354835 NA 0.3 5.4 0.31 1.46e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs950776 0.752 rs62010328 chr15:78894971 C/T cg06917634 chr15:78832804 PSMA4 0.6 6.97 0.39 2.5e-11 Sudden cardiac arrest; CESC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg13126279 chr21:47581558 C21orf56 -0.49 -6.61 -0.38 2.13e-10 Testicular germ cell tumor; CESC cis rs9287719 0.967 rs11687023 chr2:10741412 G/A cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11817453 chr19:8464850 RAB11B -0.56 -6.26 -0.36 1.58e-9 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg27170947 chr2:26402098 FAM59B -0.6 -7.25 -0.41 4.7e-12 Gut microbiome composition (summer); CESC cis rs17362650 1.000 rs66835002 chr2:9655260 T/C cg12832956 chr2:9616023 IAH1 -0.52 -5.09 -0.3 6.69e-7 Alcohol dependence (age at onset); CESC cis rs8005677 1.000 rs4982706 chr14:23381697 C/T cg25600027 chr14:23388339 RBM23 -0.43 -5.33 -0.31 2.08e-7 Cognitive ability (multi-trait analysis); CESC cis rs9611565 0.840 rs2234052 chr22:41777241 A/G cg03806693 chr22:41940476 POLR3H -1.07 -13.24 -0.63 4.71e-31 Vitiligo; CESC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.43 -0.37 5.88e-10 Electroencephalogram traits; CESC cis rs1799949 0.965 rs1842147 chr17:41435192 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.92 0.44 6.6e-14 Menopause (age at onset); CESC trans rs12367822 0.956 rs9706160 chr12:57184903 G/A cg26462586 chr2:11164677 NA 0.38 6.02 0.35 5.82e-9 Platelet aggregation; CESC trans rs4471313 1.000 rs10919388 chr1:170372503 A/C cg14876685 chr7:99177937 NA 0.43 6.47 0.37 4.67e-10 Waist-hip ratio; CESC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg00166722 chr3:10149974 C3orf24 0.45 5.91 0.34 1.07e-8 Alzheimer's disease; CESC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg21782813 chr7:2030301 MAD1L1 -0.48 -6.99 -0.39 2.18e-11 Bipolar disorder and schizophrenia; CESC cis rs12142240 0.667 rs12062 chr1:46830447 G/T cg00530320 chr1:46809349 NSUN4 -0.61 -8.23 -0.45 8.56e-15 Menopause (age at onset); CESC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg19717773 chr7:2847554 GNA12 -0.57 -7.91 -0.44 7.21e-14 Height; CESC cis rs75804782 0.641 rs72987304 chr2:239345532 C/T cg18131467 chr2:239335373 ASB1 -0.66 -5.48 -0.32 9.84e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs1348850 0.914 rs4893823 chr2:178285811 C/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.86 -12.8 -0.62 1.61e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2361710 0.668 rs4889830 chr17:78114528 G/A cg06718696 chr17:78121285 EIF4A3 0.45 5.36 0.31 1.82e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CESC cis rs8060686 0.641 rs2107369 chr16:68116018 A/C cg26727032 chr16:67993705 SLC12A4 -0.55 -6.58 -0.37 2.51e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs6998277 0.830 rs12543046 chr8:103603809 A/G cg10187029 chr8:103597600 NA -0.74 -10.06 -0.53 2.33e-20 Migraine; CESC cis rs9457247 1.000 rs2149085 chr6:167371110 T/C cg07741184 chr6:167504864 NA -0.3 -5.28 -0.31 2.64e-7 Crohn's disease; CESC cis rs10791097 0.694 rs1050071 chr11:130747231 C/G cg12179176 chr11:130786555 SNX19 0.69 10.2 0.53 8.25e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg26597838 chr10:835615 NA 0.68 6.26 0.36 1.56e-9 Eosinophil percentage of granulocytes; CESC cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg08564027 chr20:61660810 NA 0.9 15.36 0.69 1.69e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.95 9.46 0.5 1.79e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7312774 0.748 rs10492214 chr12:107294758 T/C cg16260113 chr12:107380972 MTERFD3 0.63 5.84 0.34 1.51e-8 Severe influenza A (H1N1) infection; CESC cis rs523522 0.962 rs9040 chr12:120900274 C/T cg27279351 chr12:120934652 DYNLL1 0.68 8.55 0.47 9.73e-16 High light scatter reticulocyte count; CESC cis rs6542838 0.609 rs12712043 chr2:99541494 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.26 -0.31 3.04e-7 Fear of minor pain; CESC cis rs561341 1.000 rs564714 chr17:30318404 C/T cg23018236 chr17:30244563 NA -0.55 -5.3 -0.31 2.42e-7 Hip circumference adjusted for BMI; CESC cis rs9858542 0.537 rs34514189 chr3:49373045 A/G cg00383909 chr3:49044727 WDR6 0.57 5.2 0.3 4.07e-7 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02514519 chr11:61348922 SYT7 -0.45 -6.04 -0.35 5.15e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7584330 0.666 rs7600317 chr2:238353513 C/T cg14458575 chr2:238380390 NA 0.71 9.55 0.51 9.12e-19 Prostate cancer; CESC cis rs35146811 0.586 rs1076237 chr7:99585441 A/C cg22906224 chr7:99728672 NA 0.42 5.06 0.3 7.83e-7 Coronary artery disease; CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg02869306 chr7:64672164 INTS4L1 -0.34 -5.45 -0.32 1.16e-7 Calcium levels; CESC cis rs863345 0.967 rs10908681 chr1:158522712 C/T cg12129480 chr1:158549410 OR10X1 -0.32 -6.5 -0.37 3.89e-10 Pneumococcal bacteremia; CESC cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg17143192 chr8:8559678 CLDN23 -0.43 -5.15 -0.3 5.12e-7 Neuroticism; CESC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg19163074 chr7:65112434 INTS4L2 0.41 5.1 0.3 6.46e-7 Aortic root size; CESC cis rs938554 0.513 rs3775948 chr4:9995182 G/C cg00071950 chr4:10020882 SLC2A9 0.66 8.52 0.46 1.19e-15 Blood metabolite levels; CESC cis rs1046896 1.000 rs1046875 chr17:80685426 A/G cg02711726 chr17:80685570 FN3KRP 0.6 9.04 0.49 3.37e-17 Glycated hemoglobin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01988550 chr7:28966659 NA 0.63 6.81 0.39 6.38e-11 Gut microbiome composition (summer); CESC cis rs9420 0.925 rs488769 chr11:57450720 A/C cg23127183 chr11:57508653 C11orf31 -0.44 -5.23 -0.31 3.51e-7 Schizophrenia; CESC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs5498 0.809 rs2075742 chr19:10401607 G/C cg21994045 chr19:10403936 ICAM5 0.43 6.13 0.35 3.13e-9 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg12927641 chr6:109611667 NA -0.42 -6.59 -0.38 2.42e-10 Reticulocyte fraction of red cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00442658 chr21:18885041 CXADR -0.47 -6.05 -0.35 4.89e-9 Fibrinogen levels; CESC cis rs17539620 0.624 rs62432739 chr6:154835926 A/G cg20019720 chr6:154832845 CNKSR3 0.47 6.13 0.35 3.21e-9 Lipoprotein (a) levels; CESC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg13393036 chr8:95962371 TP53INP1 -0.49 -10.7 -0.55 1.94e-22 Type 2 diabetes; CESC cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.35 0.31 1.93e-7 Personality dimensions; CESC cis rs2730245 0.618 rs859781 chr7:158661758 G/A cg24397884 chr7:158709396 WDR60 0.69 10.16 0.53 1.1e-20 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05221264 chr1:15783513 CELA2A -0.53 -6.4 -0.37 6.88e-10 Gut microbiome composition (summer); CESC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg04267008 chr7:1944627 MAD1L1 -0.65 -7.85 -0.43 1.05e-13 Bipolar disorder and schizophrenia; CESC trans rs35110281 0.744 rs162373 chr21:44927107 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.46 -6.2 -0.36 2.19e-9 Mean corpuscular volume; CESC cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg06108461 chr20:60628389 TAF4 -0.58 -7.59 -0.42 5.33e-13 Body mass index; CESC cis rs7631605 0.905 rs61489663 chr3:37261734 T/A cg22985146 chr3:37219077 LRRFIP2 -0.35 -5.44 -0.32 1.22e-7 Cerebrospinal P-tau181p levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26631329 chr19:19496517 GATAD2A -0.37 -6.03 -0.35 5.39e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12525736 chr1:228269915 ARF1 0.55 6.07 0.35 4.4e-9 Gut microbiome composition (summer); CESC cis rs710216 0.912 rs11537640 chr1:43424519 T/G cg07803811 chr1:43423981 SLC2A1 0.49 5.25 0.31 3.19e-7 Red cell distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16282910 chr9:112296723 NA -0.71 -8.51 -0.46 1.3e-15 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg07677032 chr17:61819896 STRADA 0.46 6.21 0.36 2.06e-9 Prudent dietary pattern; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25386820 chr18:21242428 ANKRD29 0.43 6.05 0.35 4.92e-9 Systemic lupus erythematosus; CESC cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg10556349 chr10:835070 NA 0.57 5.48 0.32 9.88e-8 Eosinophil percentage of granulocytes; CESC cis rs8072100 0.713 rs9807106 chr17:45457102 G/T cg25173405 chr17:45401733 C17orf57 -0.43 -5.42 -0.32 1.36e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs56046484 0.871 rs62021203 chr15:85564077 C/T cg08123816 chr15:85640762 PDE8A -0.48 -5.67 -0.33 3.82e-8 Testicular germ cell tumor; CESC cis rs2832191 0.903 rs11700687 chr21:30486767 A/G cg08807101 chr21:30365312 RNF160 -0.66 -9.01 -0.48 4.11e-17 Dental caries; CESC cis rs17253792 0.822 rs10150498 chr14:56064124 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.83 6.18 0.36 2.36e-9 Putamen volume; CESC trans rs11098499 0.863 rs2291185 chr4:120434833 C/A cg25214090 chr10:38739885 LOC399744 0.69 9.45 0.5 1.84e-18 Corneal astigmatism; CESC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 6.77 0.38 8.17e-11 Bipolar disorder; CESC cis rs7772486 0.686 rs9399564 chr6:146078907 C/T cg05347473 chr6:146136440 FBXO30 -0.53 -6.97 -0.39 2.49e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg04317338 chr11:64019027 PLCB3 0.88 9.18 0.49 1.29e-17 Mean platelet volume; CESC cis rs6547741 0.788 rs7595739 chr2:27874563 G/T cg27432699 chr2:27873401 GPN1 -0.55 -7.99 -0.44 4.19e-14 Oral cavity cancer; CESC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.16 0.81 2.75e-62 Prudent dietary pattern; CESC cis rs8020095 0.571 rs8018750 chr14:67435567 T/G cg19548862 chr14:67692701 FAM71D -0.49 -6.02 -0.35 5.66e-9 Depression (quantitative trait); CESC cis rs748404 0.578 rs573615 chr15:43614281 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.6 8.0 0.44 3.9e-14 Lung cancer; CESC cis rs12478296 0.892 rs11897561 chr2:243014976 C/A cg06360820 chr2:242988706 NA -0.77 -9.5 -0.5 1.33e-18 Obesity-related traits; CESC cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg02297831 chr4:17616191 MED28 0.47 5.79 0.33 2.02e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg18876405 chr7:65276391 NA -0.68 -9.5 -0.5 1.27e-18 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10736404 chr2:62115920 CCT4 0.51 6.19 0.36 2.29e-9 Gut microbiome composition (summer); CESC cis rs6762 0.719 rs7936806 chr11:839186 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.66 -8.51 -0.46 1.28e-15 Mean platelet volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13686143 chr2:201828163 ORC2L -0.51 -7.44 -0.42 1.37e-12 Gambling; CESC cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.22e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg10883421 chr6:151773342 RMND1;C6orf211 0.87 15.14 0.68 9.75e-38 Menarche (age at onset); CESC cis rs6831352 0.879 rs56272995 chr4:100060882 A/G cg12011299 chr4:100065546 ADH4 -0.59 -6.59 -0.38 2.35e-10 Alcohol dependence; CESC cis rs34375054 0.738 rs3751181 chr12:125626535 A/G cg21269045 chr12:125625041 AACS -0.34 -5.21 -0.3 3.74e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs9807841 0.538 rs892086 chr19:10837677 C/T cg17710535 chr19:10819994 QTRT1 0.4 5.92 0.34 1.02e-8 Inflammatory skin disease; CESC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg18402987 chr7:1209562 NA 0.73 7.77 0.43 1.71e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7107174 0.688 rs869202 chr11:78127914 A/G cg02023728 chr11:77925099 USP35 0.43 5.48 0.32 1.01e-7 Testicular germ cell tumor; CESC cis rs4953076 0.573 rs6726680 chr2:44406686 C/G cg04920474 chr2:44395004 PPM1B 0.56 7.12 0.4 1.02e-11 Height; CESC cis rs5769765 0.954 rs5770707 chr22:50244533 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.47 5.47 0.32 1.07e-7 Schizophrenia; CESC cis rs7843479 0.965 rs4636204 chr8:21823206 T/G cg17168535 chr8:21777572 XPO7 0.47 6.3 0.36 1.24e-9 Mean corpuscular volume; CESC trans rs3087243 0.755 rs231796 chr2:204704702 G/A cg01841312 chr10:38069945 NA 0.38 6.35 0.36 9.06e-10 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC trans rs7395662 0.591 rs4882110 chr11:48558249 G/T cg00717180 chr2:96193071 NA -0.44 -6.06 -0.35 4.58e-9 HDL cholesterol; CESC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.21 -0.41 5.76e-12 Developmental language disorder (linguistic errors); CESC cis rs7851660 0.809 rs7032086 chr9:100656402 T/G cg13688889 chr9:100608707 NA -0.63 -8.84 -0.48 1.4e-16 Strep throat; CESC cis rs2841277 0.741 rs9672139 chr14:105408182 T/G cg14403583 chr14:105418241 AHNAK2 -0.65 -9.24 -0.49 8.54e-18 Rheumatoid arthritis; CESC cis rs10089 1.000 rs72794396 chr5:127501386 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 9.53 0.51 1.09e-18 Ileal carcinoids; CESC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg08888203 chr3:10149979 C3orf24 0.47 5.91 0.34 1.05e-8 Alzheimer's disease; CESC cis rs6089584 0.586 rs4925216 chr20:60599923 G/A cg24733560 chr20:60626293 TAF4 0.42 6.17 0.35 2.59e-9 Body mass index; CESC trans rs208520 1.000 rs12199876 chr6:66989469 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 9.4 0.5 2.73e-18 Exhaled nitric oxide output; CESC cis rs826838 0.616 rs10880754 chr12:38628154 C/T cg26384229 chr12:38710491 ALG10B -0.44 -5.93 -0.34 9.67e-9 Heart rate; CESC cis rs838147 0.537 rs504963 chr19:49208865 G/A cg21064579 chr19:49206444 FUT2 0.44 6.16 0.35 2.76e-9 Dietary macronutrient intake; CESC cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg02990361 chr1:107599529 PRMT6 -0.44 -5.03 -0.3 8.9e-7 Facial morphology (factor 21, depth of nasal alae); CESC cis rs8072100 0.738 rs3736438 chr17:45486651 T/G cg08085267 chr17:45401833 C17orf57 -0.52 -6.64 -0.38 1.81e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7208859 0.510 rs216402 chr17:28917126 A/T cg19761014 chr17:28927070 LRRC37B2 0.87 6.68 0.38 1.41e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7560272 0.588 rs4852959 chr2:73880601 C/A cg20560298 chr2:73613845 ALMS1 0.49 6.83 0.39 5.79e-11 Schizophrenia; CESC cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg15017067 chr4:17643749 FAM184B 0.36 5.16 0.3 4.78e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3096299 0.933 rs3114848 chr16:89452771 G/A cg08822215 chr16:89438651 ANKRD11 -0.43 -6.7 -0.38 1.25e-10 Multiple myeloma (IgH translocation); CESC cis rs9308731 0.591 rs9808225 chr2:111943514 A/G cg04202892 chr2:111875749 ACOXL 0.37 5.17 0.3 4.61e-7 Chronic lymphocytic leukemia; CESC cis rs2249625 0.564 rs2496489 chr6:72877338 G/A cg18830697 chr6:72922368 RIMS1 -0.47 -6.84 -0.39 5.38e-11 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs9581857 0.579 rs9581843 chr13:27980507 T/G cg01674679 chr13:27998804 GTF3A -0.66 -5.26 -0.31 2.91e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs12681288 0.823 rs2701906 chr8:1003316 T/C cg15309053 chr8:964076 NA 0.36 6.27 0.36 1.42e-9 Schizophrenia; CESC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg19468946 chr17:37922297 IKZF3 -0.39 -5.13 -0.3 5.47e-7 Glomerular filtration rate (creatinine); CESC cis rs4563143 0.675 rs56407818 chr19:29279379 G/A cg04546413 chr19:29218101 NA 0.55 7.35 0.41 2.45e-12 Methadone dose in opioid dependence; CESC cis rs11112613 0.609 rs6539218 chr12:105934875 C/T cg03607813 chr12:105948248 NA 0.53 5.98 0.34 7.15e-9 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs7255436 0.965 rs11666233 chr19:8452045 G/T cg16745616 chr19:8428856 ANGPTL4 -0.37 -5.56 -0.32 6.47e-8 HDL cholesterol; CESC cis rs258892 0.895 rs266424 chr5:72122660 G/A cg21869765 chr5:72125136 TNPO1 -0.44 -5.65 -0.33 4.05e-8 Small cell lung carcinoma; CESC cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.24e-9 Extrinsic epigenetic age acceleration; CESC cis rs854765 0.663 rs16960744 chr17:17755259 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.66 -0.38 1.55e-10 Total body bone mineral density; CESC cis rs8077889 0.871 rs11079838 chr17:41898971 G/A cg26893861 chr17:41843967 DUSP3 0.77 10.14 0.53 1.23e-20 Triglycerides; CESC cis rs9611565 0.559 rs5758397 chr22:42019251 C/T cg17376030 chr22:41985996 PMM1 -0.81 -8.97 -0.48 5.53e-17 Vitiligo; CESC cis rs459571 0.959 rs408307 chr9:136892523 A/G cg13789015 chr9:136890014 NCRNA00094 -0.49 -7.14 -0.4 8.86e-12 Platelet distribution width; CESC cis rs7662987 1.000 rs17595424 chr4:99993869 G/T cg13256891 chr4:100009986 ADH5 -0.76 -5.58 -0.32 5.86e-8 Smoking initiation; CESC trans rs61931739 0.534 rs11052991 chr12:34059018 G/T cg26384229 chr12:38710491 ALG10B -0.51 -6.9 -0.39 3.79e-11 Morning vs. evening chronotype; CESC cis rs4423214 1.000 rs4944946 chr11:71159429 G/A cg24826892 chr11:71159390 DHCR7 0.47 5.55 0.32 6.97e-8 Vitamin D levels; CESC cis rs754466 0.510 rs55893027 chr10:79588209 C/T cg17075019 chr10:79541650 NA -0.75 -12.07 -0.6 4.96e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3733585 0.673 rs7378340 chr4:9955198 C/T cg11266682 chr4:10021025 SLC2A9 -0.57 -10.74 -0.55 1.39e-22 Cleft plate (environmental tobacco smoke interaction); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg01723929 chr2:61645604 SNORA70B;USP34 0.4 6.44 0.37 5.51e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2732480 0.538 rs2732462 chr12:48696384 A/G cg24011408 chr12:48396354 COL2A1 0.41 5.62 0.33 4.74e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs8067545 0.611 rs2703777 chr17:20138891 C/T cg13482628 chr17:19912719 NA -0.42 -5.52 -0.32 8.04e-8 Schizophrenia; CESC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg11211951 chr8:145729740 GPT 0.43 6.95 0.39 2.82e-11 Age at first birth; CESC cis rs6089584 0.586 rs1079755 chr20:60615262 G/A cg24733560 chr20:60626293 TAF4 0.45 6.74 0.38 9.7e-11 Body mass index; CESC trans rs79976124 0.837 rs74327235 chr6:66648353 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 8.71 0.47 3.31e-16 Type 2 diabetes; CESC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg16928487 chr17:17741425 SREBF1 0.45 6.84 0.39 5.58e-11 Total body bone mineral density; CESC cis rs2485892 0.581 rs2484032 chr1:210317225 G/A cg12034118 chr1:209979487 IRF6 0.46 5.07 0.3 7.42e-7 Manic episodes in bipolar disorder; CESC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg18876405 chr7:65276391 NA 0.52 6.87 0.39 4.49e-11 Aortic root size; CESC cis rs4604732 0.536 rs12058821 chr1:247649651 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.63 8.34 0.46 3.98e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6987853 0.814 rs2167338 chr8:42455079 A/G cg09913449 chr8:42400586 C8orf40 0.41 6.97 0.39 2.57e-11 Mean corpuscular hemoglobin concentration; CESC cis rs11098499 0.954 rs56270433 chr4:120406030 C/T cg09307838 chr4:120376055 NA 0.93 13.07 0.63 1.78e-30 Corneal astigmatism; CESC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg02221750 chr19:17393354 ANKLE1 -0.5 -6.0 -0.35 6.45e-9 Systemic lupus erythematosus; CESC cis rs6089584 1.000 rs6089585 chr20:60564395 G/A cg06108461 chr20:60628389 TAF4 -0.78 -11.36 -0.57 1.25e-24 Body mass index; CESC cis rs7267979 0.903 rs2500400 chr20:25354705 A/G cg08601574 chr20:25228251 PYGB -0.36 -5.05 -0.3 8.13e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs17539620 0.624 rs62432735 chr6:154834055 T/C cg17771515 chr6:154831774 CNKSR3 0.59 5.65 0.33 4.23e-8 Lipoprotein (a) levels; CESC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg03576123 chr11:487126 PTDSS2 -1.1 -10.88 -0.56 5.02e-23 Body mass index; CESC cis rs763121 0.853 rs5757196 chr22:39039855 G/C cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs7927771 0.832 rs10838699 chr11:47386073 T/C cg05585544 chr11:47624801 NA 0.49 7.13 0.4 9.38e-12 Subjective well-being; CESC cis rs2637266 0.655 rs846595 chr10:78531300 C/T cg18941641 chr10:78392320 NA 0.41 7.81 0.43 1.34e-13 Pulmonary function; CESC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs2243480 1.000 rs160644 chr7:65558186 C/T cg12463550 chr7:65579703 CRCP 0.74 5.71 0.33 3.02e-8 Diabetic kidney disease; CESC cis rs911555 0.755 rs10144051 chr14:103885931 A/C cg24130564 chr14:104152367 KLC1 -0.52 -7.05 -0.4 1.56e-11 Intelligence (multi-trait analysis); CESC cis rs2952156 0.959 rs2517956 chr17:37843859 G/A cg20243544 chr17:37824526 PNMT 0.64 7.91 0.44 6.98e-14 Asthma; CESC cis rs1008375 0.966 rs28441502 chr4:17598384 G/A cg15017067 chr4:17643749 FAM184B 0.36 5.15 0.3 5.2e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg22920501 chr2:26401640 FAM59B 0.73 8.12 0.45 1.78e-14 Gut microbiome composition (summer); CESC cis rs9790314 0.934 rs9290074 chr3:160997823 T/C cg04691961 chr3:161091175 C3orf57 -0.41 -5.27 -0.31 2.87e-7 Morning vs. evening chronotype; CESC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg08499158 chr17:42289980 UBTF -0.52 -6.54 -0.37 3.23e-10 Total body bone mineral density; CESC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg26335602 chr6:28129616 ZNF389 0.36 5.23 0.31 3.53e-7 Cardiac Troponin-T levels; CESC cis rs6964587 1.000 rs4727266 chr7:91570129 C/T cg17063962 chr7:91808500 NA -0.57 -7.62 -0.42 4.53e-13 Breast cancer; CESC cis rs77216612 0.835 rs10845621 chr12:12887977 C/T cg04607235 chr12:12878440 APOLD1 -1.0 -15.12 -0.68 1.12e-37 Lymphocyte counts; CESC cis rs9910055 0.573 rs113184718 chr17:42206543 A/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.48 -7.22 -0.41 5.57e-12 Total body bone mineral density; CESC cis rs8027181 0.839 rs11072385 chr15:73020839 A/G cg25632853 chr15:73088954 NA 0.31 5.52 0.32 7.91e-8 Triglyceride levels; CESC cis rs4481887 0.927 rs7521689 chr1:248435831 G/T cg00666640 chr1:248458726 OR2T12 0.41 6.91 0.39 3.65e-11 Common traits (Other); CESC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs1707322 0.963 rs11211238 chr1:46449415 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02951021 chr12:120934296 DYNLL1 0.51 7.29 0.41 3.51e-12 Gut microbiota (bacterial taxa); CESC cis rs1882538 0.569 rs11562037 chr7:133076885 A/G cg10665199 chr7:133106180 EXOC4 0.56 7.75 0.43 1.92e-13 Intelligence (multi-trait analysis); CESC cis rs10979 0.557 rs9403517 chr6:143909400 T/C cg25407410 chr6:143891975 LOC285740 -0.49 -6.47 -0.37 4.64e-10 Hypospadias; CESC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg18876405 chr7:65276391 NA 0.51 5.96 0.34 8.21e-9 Aortic root size; CESC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg18252515 chr7:66147081 NA -0.47 -6.08 -0.35 4.25e-9 Aortic root size; CESC cis rs17401966 0.798 rs12408435 chr1:10323342 T/A cg15208524 chr1:10270712 KIF1B 0.49 6.23 0.36 1.86e-9 Hepatocellular carcinoma; CESC cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg21918786 chr6:109611834 NA -0.39 -5.98 -0.34 7.14e-9 Reticulocyte fraction of red cells; CESC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.56 6.31 0.36 1.16e-9 Total body bone mineral density; CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 6.89 0.39 3.98e-11 Bipolar disorder; CESC cis rs2839186 0.749 rs62226489 chr21:47710519 T/C cg10351095 chr21:47802916 PCNT -0.5 -6.75 -0.38 9.55e-11 Testicular germ cell tumor; CESC cis rs7527798 0.592 rs1323720 chr1:207823161 T/C cg21110645 chr1:207815933 NA -0.33 -5.94 -0.34 9.12e-9 Erythrocyte sedimentation rate; CESC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg04944784 chr2:26401820 FAM59B -0.78 -8.86 -0.48 1.18e-16 Gut microbiome composition (summer); CESC cis rs7107174 1.000 rs7113042 chr11:78035832 C/T cg02023728 chr11:77925099 USP35 -0.42 -5.9 -0.34 1.11e-8 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02092590 chr10:3827595 KLF6 0.54 6.43 0.37 6.03e-10 Gut microbiome composition (summer); CESC cis rs4699052 0.507 rs7662107 chr4:104258396 C/T cg16532752 chr4:104119610 CENPE -0.54 -7.05 -0.4 1.53e-11 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.10.1676711F chr10:79552784 DLG5 -0.53 -6.15 -0.35 2.92e-9 Gut microbiome composition (summer); CESC cis rs2859741 1.000 rs1773575 chr1:37505129 T/C cg09363841 chr1:37513479 NA -0.67 -10.84 -0.55 6.41e-23 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs41271473 0.607 rs10916361 chr1:228859971 A/T cg00850481 chr1:228891306 NA -0.4 -5.15 -0.3 5.04e-7 Chronic lymphocytic leukemia; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg18401262 chr18:12672632 CEP76 0.4 6.1 0.35 3.78e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.07 0.3 7.33e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg07701084 chr6:150067640 NUP43 0.45 6.34 0.36 9.76e-10 Lung cancer; CESC cis rs9522267 1.000 rs9522265 chr13:112195182 A/G cg10483660 chr13:112241077 NA -0.3 -5.04 -0.3 8.69e-7 Hepatitis; CESC trans rs875971 1.000 rs6945843 chr7:65734783 G/A cg26939375 chr7:64535504 NA -0.46 -6.04 -0.35 5.27e-9 Aortic root size; CESC cis rs10206020 0.885 rs11897246 chr2:1574541 A/C cg26248373 chr2:1572462 NA -0.6 -6.96 -0.39 2.75e-11 IgG glycosylation; CESC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs7116495 0.609 rs628025 chr11:71802351 A/C cg07596299 chr11:71824057 C11orf51 -0.82 -5.15 -0.3 5.06e-7 Severe influenza A (H1N1) infection; CESC cis rs7640424 0.589 rs7612356 chr3:107811037 C/G cg09227934 chr3:107805635 CD47 -0.44 -5.32 -0.31 2.2e-7 Body mass index; CESC cis rs8062405 0.965 rs7359397 chr16:28885659 C/T cg05966235 chr16:28915196 ATP2A1 0.34 5.03 0.3 9.05e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg00166722 chr3:10149974 C3orf24 0.51 6.38 0.37 7.76e-10 Alzheimer's disease; CESC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.67 0.38 1.49e-10 Bipolar disorder; CESC cis rs7246865 0.954 rs10427132 chr19:17207156 T/G cg19418318 chr19:17219073 MYO9B 0.36 5.77 0.33 2.23e-8 Reticulocyte fraction of red cells; CESC cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg05313129 chr8:58192883 C8orf71 -0.57 -6.47 -0.37 4.59e-10 Developmental language disorder (linguistic errors); CESC cis rs12148488 0.816 rs4886655 chr15:75385568 C/T cg09165964 chr15:75287851 SCAMP5 0.58 7.7 0.43 2.71e-13 Caffeine consumption; CESC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg23161317 chr6:28129485 ZNF389 0.37 5.15 0.3 5.08e-7 Cardiac Troponin-T levels; CESC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg23248424 chr5:179741104 GFPT2 -0.7 -9.54 -0.51 1.01e-18 Height; CESC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.59 -0.38 2.36e-10 Parkinson's disease; CESC cis rs4253772 0.591 rs9615938 chr22:46689468 G/A cg00784671 chr22:46762841 CELSR1 -0.58 -5.61 -0.33 4.99e-8 LDL cholesterol;Cholesterol, total; CESC cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg08213375 chr14:104286397 PPP1R13B 0.31 5.1 0.3 6.45e-7 Reticulocyte count; CESC cis rs4969178 0.620 rs7219625 chr17:76390080 C/T cg05887092 chr17:76393375 PGS1 0.68 11.26 0.57 2.77e-24 HDL cholesterol levels; CESC cis rs72781680 0.821 rs2176265 chr2:24158638 C/G cg08917208 chr2:24149416 ATAD2B 0.59 5.9 0.34 1.12e-8 Lymphocyte counts; CESC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg16145915 chr7:1198662 ZFAND2A -0.56 -8.66 -0.47 4.79e-16 Longevity;Endometriosis; CESC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg17376030 chr22:41985996 PMM1 0.71 7.74 0.43 2.12e-13 Vitiligo; CESC cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg06212747 chr3:49208901 KLHDC8B 0.64 8.59 0.47 7.6e-16 Parkinson's disease; CESC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg03806693 chr22:41940476 POLR3H 1.19 14.07 0.65 6.09e-34 Crohn's disease;Inflammatory bowel disease; CESC cis rs66887589 0.592 rs62320740 chr4:120279486 C/A cg09307838 chr4:120376055 NA 0.66 9.16 0.49 1.47e-17 Diastolic blood pressure; CESC cis rs72781680 1.000 rs56068891 chr2:24230633 A/G cg20701182 chr2:24300061 SF3B14 0.82 6.96 0.39 2.66e-11 Lymphocyte counts; CESC cis rs4851870 0.874 rs7589902 chr2:106454419 C/G cg16077055 chr2:106428750 NCK2 -0.39 -5.06 -0.3 7.74e-7 Addiction; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08399230 chr16:4665037 FAM100A -0.47 -6.57 -0.37 2.61e-10 Fibrinogen levels; CESC cis rs7084402 0.817 rs7099496 chr10:60265242 G/A cg07615347 chr10:60278583 BICC1 -0.57 -8.7 -0.47 3.68e-16 Refractive error; CESC cis rs4704187 0.687 rs7720620 chr5:74366023 A/G cg03227963 chr5:74354835 NA 0.31 5.68 0.33 3.62e-8 Response to amphetamines; CESC cis rs9911578 1.000 rs11869828 chr17:56609525 G/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.53 -0.32 7.63e-8 Intelligence (multi-trait analysis); CESC cis rs36051895 0.659 rs10974935 chr9:5050307 C/T cg02405213 chr9:5042618 JAK2 -0.44 -5.36 -0.31 1.8e-7 Pediatric autoimmune diseases; CESC cis rs9911578 0.967 rs2429369 chr17:56501420 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.35 0.31 1.87e-7 Intelligence (multi-trait analysis); CESC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg10691866 chr7:65817282 TPST1 -0.31 -5.16 -0.3 4.78e-7 Aortic root size; CESC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg27535305 chr1:53392650 SCP2 -0.33 -5.48 -0.32 1e-7 Monocyte count; CESC cis rs698813 0.774 rs1085492 chr2:44609371 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.53 0.32 7.62e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs826838 1.000 rs826892 chr12:39100790 T/C cg26384229 chr12:38710491 ALG10B -0.62 -9.93 -0.52 5.65e-20 Heart rate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07355551 chr20:2489285 ZNF343 -0.44 -6.29 -0.36 1.31e-9 Gambling; CESC cis rs963731 0.579 rs963730 chr2:39216773 T/C cg04010122 chr2:39346883 SOS1 -0.57 -5.13 -0.3 5.66e-7 Corticobasal degeneration; CESC cis rs644799 0.965 rs11021317 chr11:95517576 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.57 0.51 8.21e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2882667 0.858 rs11949916 chr5:138396277 T/G cg04439458 chr5:138467593 SIL1 -0.37 -5.84 -0.34 1.56e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs72945132 0.769 rs3781645 chr11:70190374 T/C cg14191688 chr11:70257035 CTTN 0.43 5.5 0.32 8.9e-8 Coronary artery disease; CESC cis rs9788682 0.747 rs11072766 chr15:78771546 C/T cg24631222 chr15:78858424 CHRNA5 0.62 7.26 0.41 4.19e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs116095464 0.614 rs10061564 chr5:271329 T/C cg22496380 chr5:211416 CCDC127 -0.75 -8.59 -0.47 7.5e-16 Breast cancer; CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg05332525 chr7:65337924 VKORC1L1 0.47 5.95 0.34 8.31e-9 Calcium levels; CESC cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2249694 0.959 rs4129223 chr10:135403948 A/G cg20169779 chr10:135381914 SYCE1 -0.4 -5.77 -0.33 2.15e-8 Obesity-related traits; CESC cis rs920590 0.684 rs57462676 chr8:19670848 G/C cg03894339 chr8:19674705 INTS10 0.63 7.11 0.4 1.08e-11 Acute lymphoblastic leukemia (childhood); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01737507 chr5:122372093 PPIC -0.41 -6.62 -0.38 2.03e-10 Gambling; CESC cis rs897984 0.542 rs6565217 chr16:31083324 C/T cg02466173 chr16:30829666 NA -0.4 -7.02 -0.4 1.89e-11 Dementia with Lewy bodies; CESC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg26335602 chr6:28129616 ZNF389 0.47 6.41 0.37 6.65e-10 Depression; CESC cis rs921665 0.680 rs76494865 chr2:3191204 G/A cg02624386 chr2:3182749 NA 0.53 5.24 0.31 3.23e-7 World class endurance athleticism; CESC cis rs6546550 0.658 rs10186725 chr2:70015491 A/G cg02498382 chr2:70120550 SNRNP27 -0.32 -5.5 -0.32 8.82e-8 Prevalent atrial fibrillation; CESC trans rs801193 1.000 rs2659906 chr7:66165310 T/C cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC cis rs12464559 0.649 rs4450595 chr2:152622603 T/C cg01189475 chr2:152685088 ARL5A 0.66 5.77 0.33 2.26e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs1707322 0.717 rs11211161 chr1:46148138 A/C cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17818399 0.547 rs4952831 chr2:46761181 G/A cg02822958 chr2:46747628 ATP6V1E2 0.44 5.19 0.3 4.14e-7 Height; CESC cis rs6582630 0.519 rs2387812 chr12:38381480 A/G cg26384229 chr12:38710491 ALG10B 0.69 10.38 0.54 2.09e-21 Drug-induced liver injury (flucloxacillin); CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg06766273 chr11:62521983 ZBTB3 0.47 6.13 0.35 3.26e-9 Obesity-related traits; CESC cis rs8062405 0.964 rs11864107 chr16:28885931 T/C cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6754311 0.510 rs1374329 chr2:136421323 A/G cg07169764 chr2:136633963 MCM6 0.81 9.94 0.52 5.26e-20 Mosquito bite size; CESC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg04369109 chr6:150039330 LATS1 -0.38 -5.32 -0.31 2.22e-7 Lung cancer; CESC cis rs897984 0.762 rs7204459 chr16:30984212 G/A cg00531865 chr16:30841666 NA 0.51 7.03 0.4 1.76e-11 Dementia with Lewy bodies; CESC cis rs8067354 0.574 rs1292033 chr17:57990597 A/T cg13753209 chr17:57696993 CLTC 0.51 5.47 0.32 1.04e-7 Hemoglobin concentration; CESC cis rs3126085 0.935 rs10888468 chr1:152181539 C/T cg26876637 chr1:152193138 HRNR 0.48 5.44 0.32 1.21e-7 Atopic dermatitis; CESC cis rs6484504 0.600 rs1323738 chr11:31344898 T/C cg14844989 chr11:31128820 NA 0.39 5.47 0.32 1.06e-7 Red blood cell count; CESC cis rs4974559 0.739 rs10029534 chr4:1322908 C/A cg02980000 chr4:1222292 CTBP1 0.83 7.49 0.42 1.04e-12 Systolic blood pressure; CESC cis rs3799379 0.530 rs10456045 chr6:26404958 A/G cg12826209 chr6:26865740 GUSBL1 -0.44 -5.36 -0.31 1.81e-7 Intelligence (multi-trait analysis); CESC cis rs155076 1.000 rs155076 chr13:21870114 A/G cg11317459 chr13:21872234 NA -1.15 -12.75 -0.62 2.31e-29 White matter hyperintensity burden; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26346718 chr17:79482045 NA 0.55 6.15 0.35 2.81e-9 Gut microbiome composition (summer); CESC cis rs9858542 0.903 rs35999162 chr3:49597230 C/G cg03060546 chr3:49711283 APEH -0.49 -5.77 -0.33 2.18e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg00166722 chr3:10149974 C3orf24 0.54 6.89 0.39 4.08e-11 Alzheimer's disease; CESC trans rs4671386 0.901 rs2110402 chr2:60522038 T/C cg24386296 chr4:1723849 TMEM129;TACC3 0.51 6.39 0.37 7.28e-10 Acne (severe); CESC cis rs708547 0.792 rs7667084 chr4:57727435 T/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.56 -6.13 -0.35 3.12e-9 Response to bleomycin (chromatid breaks); CESC cis rs9633740 1.000 rs7910643 chr10:82251769 G/A cg00277334 chr10:82204260 NA -0.57 -5.73 -0.33 2.69e-8 Post bronchodilator FEV1; CESC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg07930192 chr7:1003750 NA 0.41 5.53 0.32 7.54e-8 Longevity;Endometriosis; CESC cis rs2880765 0.566 rs17553790 chr15:86013665 C/T cg19183879 chr15:85880815 NA 0.32 6.05 0.35 5.04e-9 Coronary artery disease; CESC cis rs1348850 0.914 rs2060929 chr2:178280031 T/C cg23306229 chr2:178417860 TTC30B 0.65 8.41 0.46 2.59e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1506636 0.962 rs1472808 chr7:123354536 A/G cg03229431 chr7:123269106 ASB15 -0.52 -6.91 -0.39 3.58e-11 Plateletcrit;Platelet count; CESC cis rs9443645 0.527 rs10943588 chr6:79510994 A/C cg05283184 chr6:79620031 NA -0.35 -5.05 -0.3 8.26e-7 Intelligence (multi-trait analysis); CESC cis rs910316 1.000 rs175426 chr14:75624134 C/T cg08847533 chr14:75593920 NEK9 -0.98 -18.95 -0.76 3.4e-51 Height; CESC cis rs10129255 0.536 rs8004835 chr14:107142378 A/C cg23076370 chr14:107095027 NA -0.53 -7.54 -0.42 7.43e-13 Kawasaki disease; CESC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg07936489 chr17:37558343 FBXL20 -0.81 -12.02 -0.59 7.28e-27 Glomerular filtration rate (creatinine); CESC cis rs17376456 0.877 rs12716460 chr5:93416733 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.59 5.04 0.3 8.45e-7 Diabetic retinopathy; CESC cis rs6831352 0.918 rs29001194 chr4:100054844 A/G cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs7044106 0.762 rs10760112 chr9:123467570 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.86 14.18 0.66 2.38e-34 Hip circumference adjusted for BMI; CESC cis rs9902453 0.967 rs6505155 chr17:28372783 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.09e-13 Coffee consumption (cups per day); CESC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg00409905 chr10:38381863 ZNF37A -0.47 -6.33 -0.36 1.04e-9 Extrinsic epigenetic age acceleration; CESC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs7772486 0.790 rs4075694 chr6:146251108 G/C cg05347473 chr6:146136440 FBXO30 -0.57 -7.26 -0.41 4.32e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1707322 0.686 rs3014242 chr1:46087577 G/A cg05343316 chr1:45956843 TESK2 -0.52 -6.36 -0.36 8.77e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg20503657 chr10:835505 NA 0.76 7.62 0.42 4.4e-13 Eosinophil percentage of granulocytes; CESC cis rs3105593 1.000 rs56015123 chr15:50977228 G/A cg08437265 chr15:50716283 USP8 0.46 6.06 0.35 4.64e-9 QT interval; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15450734 chr14:103541957 NA 0.47 6.11 0.35 3.54e-9 Systemic lupus erythematosus; CESC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg20243544 chr17:37824526 PNMT 0.45 5.51 0.32 8.31e-8 Glomerular filtration rate (creatinine); CESC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg06808227 chr14:105710500 BRF1 -0.55 -6.4 -0.37 6.84e-10 Mean platelet volume;Platelet distribution width; CESC cis rs116095464 0.558 rs112343653 chr5:257174 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.28 0.31 2.76e-7 Breast cancer; CESC cis rs1669338 0.588 rs55959448 chr3:3204000 C/T cg16797762 chr3:3221439 CRBN -0.63 -6.72 -0.38 1.09e-10 White matter integrity; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg02306730 chr19:39109456 MAP4K1;EIF3K 0.49 6.29 0.36 1.28e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg17211192 chr8:82754475 SNX16 -0.68 -8.13 -0.45 1.65e-14 Diastolic blood pressure; CESC cis rs7520050 0.966 rs4660321 chr1:46366760 A/G cg03146154 chr1:46216737 IPP -0.48 -6.34 -0.36 1e-9 Red blood cell count;Reticulocyte count; CESC cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg22455342 chr2:225449267 CUL3 -0.68 -9.35 -0.5 3.86e-18 IgE levels in asthmatics (D.p. specific); CESC cis rs1707322 0.721 rs10749856 chr1:46164846 A/T cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs57221529 0.563 rs4957057 chr5:569230 C/G cg09021430 chr5:549028 NA -0.46 -6.02 -0.35 5.64e-9 Lung disease severity in cystic fibrosis; CESC cis rs1801251 0.644 rs283473 chr2:233654847 A/G cg08000102 chr2:233561755 GIGYF2 0.66 9.71 0.51 2.84e-19 Coronary artery disease; CESC cis rs3733585 0.699 rs6823361 chr4:9963127 A/G cg02734326 chr4:10020555 SLC2A9 -0.44 -6.11 -0.35 3.58e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2797160 0.651 rs1268092 chr6:126029043 A/G cg05901451 chr6:126070800 HEY2 -0.5 -7.19 -0.4 6.75e-12 Endometrial cancer; CESC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.59 0.32 5.53e-8 Bipolar disorder; CESC cis rs7259376 0.936 rs11085524 chr19:22536422 G/C cg02657401 chr19:22469223 NA -0.26 -5.16 -0.3 4.84e-7 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18140683 chr11:2950620 PHLDA2 0.58 6.35 0.36 9.08e-10 Gut microbiome composition (summer); CESC cis rs7267979 1.000 rs2856 chr20:25433536 T/C cg08601574 chr20:25228251 PYGB 0.38 5.55 0.32 6.93e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg22875332 chr1:76189707 ACADM 0.67 7.93 0.44 6.22e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1348850 0.668 rs6734426 chr2:178493770 C/T cg23306229 chr2:178417860 TTC30B 0.59 6.8 0.39 6.78e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9911578 1.000 rs9902994 chr17:56948722 T/A cg12560992 chr17:57184187 TRIM37 0.94 15.65 0.69 1.5e-39 Intelligence (multi-trait analysis); CESC cis rs7592578 0.679 rs62181018 chr2:191323295 C/T cg27211696 chr2:191398769 TMEM194B -0.59 -5.91 -0.34 1.03e-8 Diastolic blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17014947 chr15:35529521 LOC723972 0.48 6.65 0.38 1.69e-10 Fibrinogen levels; CESC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg04267008 chr7:1944627 MAD1L1 0.58 6.99 0.39 2.18e-11 Bipolar disorder and schizophrenia; CESC cis rs6842047 1.000 rs1877320 chr4:187131279 G/A cg23442198 chr4:187126114 CYP4V2 0.72 5.83 0.34 1.62e-8 Blood protein levels; CESC cis rs709400 0.633 rs2296484 chr14:104003094 C/T cg12935359 chr14:103987150 CKB -0.52 -7.4 -0.41 1.81e-12 Body mass index; CESC cis rs1864400 0.690 rs2565200 chr10:43622933 A/G cg07801480 chr10:43725741 RASGEF1A 0.39 5.24 0.31 3.31e-7 Hirschsprung disease; CESC trans rs9858542 1.000 rs9812791 chr3:49682311 G/A cg21659725 chr3:3221576 CRBN -0.53 -6.45 -0.37 5.37e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.86 0.34 1.36e-8 Menopause (age at onset); CESC cis rs3791556 0.898 rs3791549 chr2:240109024 A/G cg03281426 chr2:240109471 HDAC4 -0.55 -7.09 -0.4 1.24e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg10057126 chr4:77819792 ANKRD56 0.55 7.92 0.44 6.47e-14 Emphysema distribution in smoking; CESC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg08704611 chr17:80376099 HEXDC;C17orf101 -0.44 -5.08 -0.3 7.2e-7 Breast cancer; CESC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg23758822 chr17:41437982 NA 1.03 15.83 0.7 3.6e-40 Menopause (age at onset); CESC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg22823121 chr1:150693482 HORMAD1 0.47 6.96 0.39 2.6e-11 Tonsillectomy; CESC cis rs2594989 1.000 rs2606747 chr3:11374955 T/C cg00170343 chr3:11313890 ATG7 0.56 5.04 0.3 8.81e-7 Circulating chemerin levels; CESC cis rs7647973 1.000 rs4241407 chr3:49600319 C/T cg06212747 chr3:49208901 KLHDC8B 0.58 7.74 0.43 2.1e-13 Menarche (age at onset); CESC cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg19748678 chr4:122722346 EXOSC9 0.79 10.06 0.53 2.23e-20 Type 2 diabetes; CESC cis rs854765 0.623 rs9893690 chr17:17753846 A/T cg09796270 chr17:17721594 SREBF1 -0.43 -6.23 -0.36 1.81e-9 Total body bone mineral density; CESC cis rs11577318 0.853 rs1071849 chr1:26646726 A/G cg00852783 chr1:26633632 UBXN11 0.49 6.82 0.39 6.07e-11 Granulocyte percentage of myeloid white cells; CESC cis rs3733585 0.699 rs7676733 chr4:9966956 G/A cg00071950 chr4:10020882 SLC2A9 -0.7 -11.44 -0.58 6.69e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10779751 0.770 rs6701524 chr1:11198502 A/G cg08854313 chr1:11322531 MTOR -0.75 -9.34 -0.5 4.11e-18 Body mass index; CESC cis rs6121246 0.697 rs6060912 chr20:30325755 C/A cg13852791 chr20:30311386 BCL2L1 0.82 8.74 0.47 2.63e-16 Mean corpuscular hemoglobin; CESC cis rs71277158 0.688 rs6781454 chr3:169823096 T/C cg04067573 chr3:169899625 PHC3 0.7 7.05 0.4 1.57e-11 Prostate cancer; CESC cis rs9488822 0.636 rs10872142 chr6:116369052 C/A cg15226275 chr6:116381976 FRK 0.25 6.35 0.36 9.34e-10 Cholesterol, total;LDL cholesterol; CESC cis rs6546550 0.868 rs12713682 chr2:70154134 G/A cg02498382 chr2:70120550 SNRNP27 -0.4 -6.95 -0.39 2.78e-11 Prevalent atrial fibrillation; CESC cis rs7917772 0.503 rs1409310 chr10:104282265 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.18 0.3 4.34e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs11971186 0.824 rs1204513 chr7:126499977 C/T cg10894441 chr11:111169905 C11orf92;C11orf93 -0.49 -6.22 -0.36 1.93e-9 Chemerin levels; CESC cis rs1559088 0.847 rs10423531 chr19:33600140 T/C cg27124370 chr19:33622961 WDR88 0.45 5.86 0.34 1.34e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7130144 0.686 rs10894216 chr11:130433733 A/G cg26307797 chr11:130446613 NA -0.56 -5.19 -0.3 4.16e-7 Urate levels in lean individuals; CESC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg23978390 chr7:1156363 C7orf50 0.45 6.0 0.35 6.45e-9 Longevity;Endometriosis; CESC cis rs4819052 0.851 rs2838867 chr21:46713092 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.5 6.12 0.35 3.39e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2933343 0.700 rs2249514 chr3:128643812 C/T cg24203234 chr3:128598194 ACAD9 0.43 5.8 0.34 1.93e-8 IgG glycosylation; CESC cis rs9611565 0.921 rs2235846 chr22:41741042 G/C cg06634786 chr22:41940651 POLR3H -0.45 -5.14 -0.3 5.43e-7 Vitiligo; CESC cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg10523679 chr1:76189770 ACADM 0.76 10.48 0.54 1e-21 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7904368 0.806 rs3858182 chr10:16855094 C/T cg14835575 chr10:16859367 RSU1 0.52 5.26 0.31 2.91e-7 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs7208859 0.673 rs55658077 chr17:29156519 A/G cg13385521 chr17:29058706 SUZ12P 0.75 6.0 0.35 6.29e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.63 0.64 2.03e-32 Prudent dietary pattern; CESC cis rs67311347 1.000 rs73076035 chr3:40439881 G/C cg09455208 chr3:40491958 NA 0.52 8.56 0.47 9.02e-16 Renal cell carcinoma; CESC cis rs951366 0.677 rs1775140 chr1:205672107 C/A cg14893161 chr1:205819251 PM20D1 0.86 13.57 0.64 3.44e-32 Menarche (age at onset); CESC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg10691866 chr7:65817282 TPST1 -0.31 -5.03 -0.3 9.12e-7 Aortic root size; CESC cis rs11696845 0.776 rs6073538 chr20:43379264 A/C cg25301532 chr20:43378953 KCNK15 0.41 6.7 0.38 1.24e-10 Obesity-related traits; CESC cis rs9467711 0.606 rs12174623 chr6:26373086 C/T cg12826209 chr6:26865740 GUSBL1 0.61 5.28 0.31 2.72e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg13206674 chr6:150067644 NUP43 0.41 5.31 0.31 2.29e-7 Lung cancer; CESC cis rs7762018 1.000 rs6941766 chr6:170131653 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.58 5.99 0.35 6.64e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs11711311 0.911 rs28577577 chr3:113447276 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.27 0.53 4.81e-21 IgG glycosylation; CESC cis rs9790314 0.846 rs4856738 chr3:160986637 C/G cg03342759 chr3:160939853 NMD3 -0.45 -6.21 -0.36 2e-9 Morning vs. evening chronotype; CESC cis rs7100689 0.725 rs10736340 chr10:82061071 C/T cg00277334 chr10:82204260 NA -0.58 -7.31 -0.41 3.1e-12 Post bronchodilator FEV1; CESC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg07677032 chr17:61819896 STRADA 0.46 6.06 0.35 4.71e-9 Prudent dietary pattern; CESC cis rs9611565 0.559 rs132771 chr22:42025350 A/G cg03806693 chr22:41940476 POLR3H 1.05 12.5 0.61 1.69e-28 Vitiligo; CESC cis rs6964587 0.541 rs6947170 chr7:91451471 A/G cg17063962 chr7:91808500 NA 0.42 5.77 0.33 2.23e-8 Breast cancer; CESC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg19163074 chr7:65112434 INTS4L2 -0.46 -5.05 -0.3 8.07e-7 Aortic root size; CESC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg04369109 chr6:150039330 LATS1 -0.4 -5.23 -0.31 3.43e-7 Lung cancer; CESC cis rs17253792 0.822 rs75115817 chr14:56069537 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC trans rs60843830 0.662 rs6721594 chr2:305203 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.58 -7.39 -0.41 1.86e-12 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1008375 1.000 rs60178264 chr4:17685308 G/T cg02297831 chr4:17616191 MED28 0.42 5.44 0.32 1.2e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9660992 0.573 rs1172161 chr1:205206495 C/T cg21643547 chr1:205240462 TMCC2 -0.39 -5.37 -0.31 1.76e-7 Mean corpuscular volume;Mean platelet volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10800280 chr6:36646508 CDKN1A -0.44 -6.32 -0.36 1.13e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6066835 0.702 rs6122709 chr20:47278938 C/A cg18078177 chr20:47281410 PREX1 0.76 5.41 0.32 1.41e-7 Multiple myeloma; CESC cis rs12477438 0.520 rs6717723 chr2:99756930 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 16.02 0.7 7.14e-41 Chronic sinus infection; CESC cis rs7474896 0.583 rs10827817 chr10:37997974 A/G cg00409905 chr10:38381863 ZNF37A -0.44 -5.04 -0.3 8.59e-7 Obesity (extreme); CESC cis rs4654899 0.802 rs1530946 chr1:21182540 A/G cg05370193 chr1:21551575 ECE1 -0.37 -5.43 -0.32 1.26e-7 Superior frontal gyrus grey matter volume; CESC cis rs4481887 1.000 rs10788781 chr1:248494262 C/T cg00666640 chr1:248458726 OR2T12 0.41 6.71 0.38 1.17e-10 Common traits (Other); CESC cis rs1256061 0.624 rs1152577 chr14:64697485 T/G cg21174375 chr14:64681225 SYNE2 0.48 6.36 0.36 8.86e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6088590 0.965 rs6120727 chr20:33374102 T/C cg08999081 chr20:33150536 PIGU 0.59 8.99 0.48 4.71e-17 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02123667 chr8:127570702 FAM84B 0.59 7.03 0.4 1.8e-11 Gut microbiome composition (summer); CESC cis rs2304069 0.545 rs11167492 chr5:149403101 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.46 6.26 0.36 1.5e-9 HIV-1 control; CESC cis rs9303280 0.836 rs11557467 chr17:38028634 G/T cg20243544 chr17:37824526 PNMT 0.51 6.68 0.38 1.38e-10 Self-reported allergy; CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg10819733 chr22:24237672 NA -0.51 -7.44 -0.42 1.41e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.51e-11 Developmental language disorder (linguistic errors); CESC cis rs35110281 0.811 rs9980185 chr21:45057905 A/G cg04455712 chr21:45112962 RRP1B 0.41 5.84 0.34 1.51e-8 Mean corpuscular volume; CESC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.76 -10.09 -0.53 1.79e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6570726 0.935 rs434298 chr6:145846873 G/A cg05347473 chr6:146136440 FBXO30 0.48 6.45 0.37 5.39e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10979 1.000 rs9386038 chr6:143896358 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg22823121 chr1:150693482 HORMAD1 0.4 5.79 0.34 1.98e-8 Melanoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02084811 chr12:49524778 TUBA1B 0.64 7.62 0.42 4.57e-13 Gut microbiome composition (summer); CESC cis rs6964587 1.000 rs60147309 chr7:91736098 C/G cg17063962 chr7:91808500 NA 0.55 7.54 0.42 7.58e-13 Breast cancer; CESC cis rs116095464 0.558 rs6878087 chr5:223117 C/T cg12570787 chr5:219185 SDHA;CCDC127 -0.52 -5.8 -0.34 1.93e-8 Breast cancer; CESC cis rs9790314 0.521 rs13084731 chr3:161086020 G/A cg03342759 chr3:160939853 NMD3 -0.41 -5.74 -0.33 2.52e-8 Morning vs. evening chronotype; CESC cis rs7809950 0.648 rs114452520 chr7:107176780 C/T cg23024343 chr7:107201750 COG5 -0.43 -6.01 -0.35 6.18e-9 Coronary artery disease; CESC cis rs6540556 0.769 rs6679405 chr1:209926468 A/C cg05527609 chr1:210001259 C1orf107 -0.5 -6.05 -0.35 4.84e-9 Red blood cell count; CESC cis rs72949976 1.000 rs62186568 chr2:214033955 G/A cg08319019 chr2:214017104 IKZF2 -0.43 -5.34 -0.31 2.05e-7 Lung cancer;Squamous cell lung carcinoma; CESC cis rs9388451 0.839 rs3799709 chr6:126078361 A/G cg05901451 chr6:126070800 HEY2 -0.65 -9.22 -0.49 9.86e-18 Brugada syndrome; CESC cis rs1499614 1.000 rs1638731 chr7:66144679 C/T cg18252515 chr7:66147081 NA -1.42 -14.52 -0.67 1.58e-35 Gout; CESC trans rs877282 0.797 rs7079164 chr10:756363 A/G cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17095167 chr13:21833918 NA -0.61 -7.06 -0.4 1.45e-11 Gut microbiome composition (summer); CESC cis rs709400 1.000 rs8018979 chr14:104109087 G/A cg24130564 chr14:104152367 KLC1 -0.42 -5.39 -0.31 1.56e-7 Body mass index; CESC cis rs6690583 0.697 rs2012369 chr1:85520845 T/C cg22153463 chr1:85462885 MCOLN2 -0.66 -8.3 -0.45 5.4e-15 Serum sulfate level; CESC cis rs1215050 0.791 rs1727278 chr4:98853576 A/G cg05340658 chr4:99064831 C4orf37 -0.5 -6.59 -0.38 2.32e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs8141529 0.509 rs6005927 chr22:29255884 A/G cg02153584 chr22:29168773 CCDC117 0.59 7.91 0.44 6.92e-14 Lymphocyte counts; CESC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.85 -0.34 1.41e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2898681 0.519 rs76606067 chr4:53728221 G/T cg00791764 chr4:53727839 RASL11B 0.45 5.28 0.31 2.63e-7 Optic nerve measurement (cup area); CESC cis rs739401 1.000 rs739401 chr11:3036324 C/T cg25174290 chr11:3078921 CARS -0.49 -6.81 -0.39 6.53e-11 Longevity; CESC cis rs7659604 0.540 rs34445121 chr4:122710889 G/A cg19748678 chr4:122722346 EXOSC9 -0.42 -5.26 -0.31 2.97e-7 Type 2 diabetes; CESC cis rs113835537 0.529 rs11227500 chr11:66273233 T/C cg24851651 chr11:66362959 CCS 0.43 5.35 0.31 1.94e-7 Airway imaging phenotypes; CESC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg02475777 chr4:1388615 CRIPAK 0.65 8.38 0.46 3.11e-15 Longevity; CESC cis rs8141529 0.732 rs6005881 chr22:29183133 A/G cg02153584 chr22:29168773 CCDC117 0.66 9.5 0.5 1.34e-18 Lymphocyte counts; CESC cis rs1847202 0.826 rs13063441 chr3:72952400 A/G cg25664220 chr3:72788482 NA -0.41 -5.93 -0.34 9.21e-9 Motion sickness; CESC cis rs3126085 0.935 rs12408581 chr1:152175211 A/G cg03465714 chr1:152285911 FLG 0.46 5.22 0.31 3.65e-7 Atopic dermatitis; CESC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg13777783 chr17:79615861 NA -0.37 -6.15 -0.35 2.83e-9 Eye color traits; CESC cis rs1847202 0.826 rs11925587 chr3:72952227 A/G cg10804678 chr3:72788309 NA 0.39 5.1 0.3 6.45e-7 Motion sickness; CESC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg22823121 chr1:150693482 HORMAD1 0.46 6.76 0.38 8.54e-11 Tonsillectomy; CESC cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg17971929 chr21:40555470 PSMG1 1.02 15.02 0.68 2.54e-37 Cognitive function; CESC cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.91 7.91 0.44 7.15e-14 Initial pursuit acceleration; CESC cis rs425277 0.917 rs12410859 chr1:2038732 C/T cg24578937 chr1:2090814 PRKCZ 0.55 9.06 0.49 2.89e-17 Height; CESC cis rs67460515 0.528 rs11915989 chr3:160902259 A/G cg03342759 chr3:160939853 NMD3 -0.54 -7.19 -0.4 6.62e-12 Parkinson's disease; CESC cis rs2404602 0.692 rs3816266 chr15:76993835 T/G cg22467129 chr15:76604101 ETFA -0.34 -5.11 -0.3 6.27e-7 Blood metabolite levels; CESC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg27297192 chr10:134578999 INPP5A 0.4 5.13 0.3 5.54e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg16325326 chr1:53192061 ZYG11B -0.98 -16.91 -0.72 5.34e-44 Monocyte count; CESC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg21984481 chr17:79567631 NPLOC4 0.35 5.52 0.32 8.09e-8 Eye color traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15627457 chr8:141535348 NA 0.53 6.98 0.39 2.34e-11 Fibrinogen levels; CESC cis rs12477438 1.000 rs1922624 chr2:99909958 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.12 -0.4 9.89e-12 Chronic sinus infection; CESC trans rs10028773 0.632 rs34481394 chr4:120248374 C/T cg25214090 chr10:38739885 LOC399744 0.62 8.36 0.46 3.48e-15 Educational attainment; CESC cis rs708547 0.599 rs1718864 chr4:57887471 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -5.52 -0.32 8.06e-8 Response to bleomycin (chromatid breaks); CESC cis rs34779708 0.966 rs17591857 chr10:35499043 A/G cg03585969 chr10:35415529 CREM -0.75 -9.86 -0.52 9.73e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs1008375 1.000 rs10939738 chr4:17604295 G/C cg27347728 chr4:17578864 LAP3 0.43 5.29 0.31 2.51e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3008870 0.583 rs2147838 chr1:67399466 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.99 11.11 0.56 8.58e-24 Lymphocyte percentage of white cells; CESC cis rs734999 0.549 rs60733400 chr1:2516781 G/A cg18854424 chr1:2615690 NA 0.27 5.21 0.31 3.72e-7 Ulcerative colitis; CESC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.95 -0.34 8.41e-9 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24158363 chr17:73401717 GRB2 0.56 6.52 0.37 3.53e-10 Gut microbiome composition (summer); CESC cis rs4595586 0.545 rs1562729 chr12:39406179 T/G cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.9 -13.68 -0.64 1.35e-32 Prudent dietary pattern; CESC cis rs3733585 0.699 rs4408959 chr4:9948868 C/T cg11266682 chr4:10021025 SLC2A9 -0.59 -11.14 -0.56 6.82e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4654899 0.802 rs17410008 chr1:21220701 G/C cg05370193 chr1:21551575 ECE1 0.4 5.77 0.33 2.24e-8 Superior frontal gyrus grey matter volume; CESC cis rs7216064 0.953 rs9890629 chr17:65871559 G/A cg07042672 chr17:66097459 LOC651250 -0.57 -6.56 -0.37 2.81e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7617480 0.648 rs9859473 chr3:48837182 A/G cg06212747 chr3:49208901 KLHDC8B 0.45 5.19 0.3 4.27e-7 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.35 0.31 1.86e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9399135 0.967 rs13218642 chr6:135309940 A/G cg24558204 chr6:135376177 HBS1L 0.5 6.74 0.38 1.01e-10 Red blood cell count; CESC cis rs796364 0.806 rs12619136 chr2:200910347 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg25517755 chr10:38738941 LOC399744 -0.49 -6.35 -0.36 9.09e-10 Extrinsic epigenetic age acceleration; CESC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg11301795 chr4:187892539 NA -0.75 -12.17 -0.6 2.31e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs728616 0.614 rs1538818 chr10:82122793 G/A cg05935833 chr10:81318306 SFTPA2 -0.45 -5.74 -0.33 2.59e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs1728785 0.786 rs1728770 chr16:68564124 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.39 0.41 1.96e-12 Ulcerative colitis; CESC cis rs7772486 0.790 rs4435956 chr6:146232403 G/C cg23711669 chr6:146136114 FBXO30 -0.92 -13.36 -0.63 1.78e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg09359103 chr1:154839909 KCNN3 -0.65 -12.57 -0.61 9.63e-29 Prostate cancer; CESC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg04414720 chr1:150670196 GOLPH3L 0.63 9.0 0.48 4.53e-17 Tonsillectomy; CESC trans rs561341 1.000 rs8069199 chr17:30281845 A/G cg27661571 chr11:113659931 NA -0.72 -7.36 -0.41 2.36e-12 Hip circumference adjusted for BMI; CESC cis rs548181 0.736 rs543389 chr11:125464841 A/G cg03464685 chr11:125439445 EI24 1.22 9.63 0.51 5.23e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs11098499 0.863 rs9884402 chr4:120489982 A/G cg09307838 chr4:120376055 NA 0.9 12.28 0.6 9.3e-28 Corneal astigmatism; CESC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs9790314 0.521 rs60625846 chr3:161084525 G/T cg03342759 chr3:160939853 NMD3 -0.41 -5.74 -0.33 2.63e-8 Morning vs. evening chronotype; CESC cis rs7312774 0.748 rs7295619 chr12:107316934 T/A cg16260113 chr12:107380972 MTERFD3 0.68 6.35 0.36 9.08e-10 Severe influenza A (H1N1) infection; CESC cis rs7845219 0.544 rs10956932 chr8:95948202 C/T cg13393036 chr8:95962371 TP53INP1 0.39 7.31 0.41 3.14e-12 Type 2 diabetes; CESC cis rs7208859 0.573 rs28779471 chr17:29084369 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs5769707 0.933 rs2157444 chr22:49994292 A/G cg05373962 chr22:49881684 NA -0.35 -5.85 -0.34 1.43e-8 Monocyte count;Monocyte percentage of white cells; CESC cis rs1568889 0.938 rs7128045 chr11:28190180 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.58 0.54 4.76e-22 Bipolar disorder; CESC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg22823121 chr1:150693482 HORMAD1 0.45 6.26 0.36 1.52e-9 Melanoma; CESC cis rs10885582 0.781 rs10159807 chr10:116293790 C/G cg17056676 chr10:116301354 ABLIM1 -0.28 -5.14 -0.3 5.47e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs2859741 0.546 rs10489413 chr1:37513906 C/T cg09363841 chr1:37513479 NA -0.57 -8.69 -0.47 3.96e-16 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC trans rs1553477 1.000 rs6875907 chr5:53112624 C/T cg02960488 chr3:178863507 NA 0.36 6.24 0.36 1.72e-9 Monobrow; CESC cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg00745463 chr17:30367425 LRRC37B -0.88 -7.97 -0.44 4.86e-14 Hip circumference adjusted for BMI; CESC cis rs12995491 0.933 rs12995212 chr2:88527184 C/T cg18490616 chr2:88469792 THNSL2 -0.5 -7.27 -0.41 4.04e-12 Response to metformin (IC50); CESC cis rs919433 0.927 rs1429412 chr2:198190894 A/G cg03934865 chr2:198174659 NA -0.49 -6.94 -0.39 3.06e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2204008 0.744 rs8186814 chr12:38335169 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.11 0.35 3.53e-9 Bladder cancer; CESC cis rs10883723 0.810 rs6584504 chr10:104253507 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.1 0.3 6.38e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs208520 1.000 rs72884017 chr6:66992513 T/G cg07460842 chr6:66804631 NA 0.88 9.99 0.52 3.87e-20 Exhaled nitric oxide output; CESC cis rs11711311 0.955 rs67550112 chr3:113401988 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.7 9.03 0.49 3.62e-17 IgG glycosylation; CESC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg06108461 chr20:60628389 TAF4 -0.92 -14.41 -0.66 3.85e-35 Body mass index; CESC cis rs863345 0.625 rs6427439 chr1:158460357 C/A cg12129480 chr1:158549410 OR10X1 -0.36 -7.14 -0.4 8.93e-12 Pneumococcal bacteremia; CESC cis rs3820928 1.000 rs1346618 chr2:227771988 C/T cg05526886 chr2:227700861 RHBDD1 0.41 5.39 0.31 1.57e-7 Pulmonary function; CESC cis rs7617773 0.784 rs9850672 chr3:48301172 C/A cg11946769 chr3:48343235 NME6 0.8 10.73 0.55 1.57e-22 Coronary artery disease; CESC cis rs12586317 0.586 rs74243590 chr14:35513246 G/A cg16230307 chr14:35515116 FAM177A1 1.13 11.81 0.59 3.79e-26 Psoriasis; CESC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg12463550 chr7:65579703 CRCP 0.49 6.21 0.36 2.07e-9 Aortic root size; CESC cis rs881375 0.933 rs7031096 chr9:123694942 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.2 0.3 4.07e-7 Rheumatoid arthritis; CESC cis rs6815814 0.950 rs5743566 chr4:38805942 G/C cg02016764 chr4:38805732 TLR1 -0.63 -7.26 -0.41 4.22e-12 Breast cancer; CESC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg18337363 chr3:52569053 NT5DC2 -0.28 -5.39 -0.31 1.52e-7 Electroencephalogram traits; CESC cis rs2629540 0.765 rs4962687 chr10:126404141 G/A cg08799069 chr10:126477246 METTL10 -0.51 -7.37 -0.41 2.16e-12 Cocaine dependence; CESC cis rs7086627 0.515 rs12245180 chr10:82211897 C/G cg00277334 chr10:82204260 NA -0.91 -16.25 -0.71 1.13e-41 Post bronchodilator FEV1; CESC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg02725872 chr8:58115012 NA -0.42 -5.87 -0.34 1.28e-8 Developmental language disorder (linguistic errors); CESC cis rs921968 0.643 rs600057 chr2:219456737 A/G cg02176678 chr2:219576539 TTLL4 0.42 7.28 0.41 3.73e-12 Mean corpuscular hemoglobin concentration; CESC trans rs17764205 0.929 rs10424718 chr19:3253630 G/T cg19557190 chr5:56469727 GPBP1 0.62 6.27 0.36 1.48e-9 Bipolar disorder and schizophrenia; CESC cis rs4950322 0.802 rs72694705 chr1:146834025 G/A cg22381352 chr1:146742008 CHD1L -0.45 -5.19 -0.3 4.12e-7 Protein quantitative trait loci; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02384530 chr12:6961868 USP5;CDCA3 0.53 6.14 0.35 3.04e-9 Gut microbiome composition (summer); CESC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg22920501 chr2:26401640 FAM59B -0.7 -8.4 -0.46 2.75e-15 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23800573 chr21:45114399 RRP1B 0.45 6.39 0.37 7.38e-10 Fibrinogen levels; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg01105932 chr5:158635248 RNF145 -0.49 -6.22 -0.36 1.88e-9 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21097105 chr17:19265900 B9D1 0.64 7.24 0.41 4.86e-12 Gut microbiome composition (summer); CESC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg11663144 chr21:46675770 NA -0.48 -6.52 -0.37 3.49e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8114671 0.562 rs6088640 chr20:33472509 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.17 0.3 4.52e-7 Height; CESC cis rs3862030 0.839 rs7078679 chr10:104284017 C/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.38 -5.26 -0.31 2.92e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.94 -0.34 9.01e-9 Total body bone mineral density; CESC cis rs1153858 1.000 rs56669689 chr15:45637729 A/C cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs763121 0.925 rs5757251 chr22:39100128 G/A cg06022373 chr22:39101656 GTPBP1 0.71 11.21 0.57 3.95e-24 Menopause (age at onset); CESC cis rs3026101 0.671 rs1806242 chr17:5304763 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06564803 chr16:70100193 PDXDC2 0.52 6.33 0.36 1.04e-9 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04936639 chr11:48922035 NA -0.37 -6.03 -0.35 5.35e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.34 0.31 1.96e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3845702 0.736 rs6733426 chr2:180830958 A/G cg01881094 chr2:180872142 CWC22 -0.98 -9.07 -0.49 2.78e-17 Schizophrenia; CESC cis rs9948 0.655 rs62156228 chr2:97420335 A/G cg01990225 chr2:97406019 LMAN2L -1.02 -7.83 -0.43 1.17e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs7301826 0.967 rs4759790 chr12:131296390 T/G cg11011512 chr12:131303247 STX2 0.4 5.09 0.3 6.77e-7 Plasma plasminogen activator levels; CESC cis rs7084402 0.967 rs1658454 chr10:60306770 G/A cg07615347 chr10:60278583 BICC1 0.59 9.34 0.5 4.23e-18 Refractive error; CESC cis rs933688 1.000 rs10058025 chr5:90689052 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 14.27 0.66 1.16e-34 Smoking behavior; CESC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg19346786 chr7:2764209 NA -0.48 -6.48 -0.37 4.51e-10 Height; CESC cis rs2249694 0.960 rs7075572 chr10:135404358 T/C cg19469447 chr10:135341870 CYP2E1 0.36 5.03 0.3 9.2e-7 Obesity-related traits; CESC cis rs9479482 0.967 rs3860823 chr6:150356526 A/G cg03788504 chr6:150331562 NA -0.31 -6.23 -0.36 1.79e-9 Alopecia areata; CESC cis rs9814567 1.000 rs9829092 chr3:134229866 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.77 -0.33 2.24e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg20503657 chr10:835505 NA 0.74 6.75 0.38 9.51e-11 Eosinophil percentage of granulocytes; CESC cis rs3784262 0.904 rs17820823 chr15:58239358 A/G cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.11 -0.3 6.29e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg03709012 chr19:19516395 GATAD2A -1.01 -15.85 -0.7 3.09e-40 Tonsillectomy; CESC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg17143192 chr8:8559678 CLDN23 0.71 7.92 0.44 6.78e-14 Obesity-related traits; CESC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg21782813 chr7:2030301 MAD1L1 0.49 7.05 0.4 1.58e-11 Bipolar disorder and schizophrenia; CESC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg02428538 chr16:24856791 SLC5A11 -0.48 -5.04 -0.3 8.45e-7 Intelligence (multi-trait analysis); CESC cis rs7208859 0.623 rs7212991 chr17:29143749 T/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -11.44 -0.58 6.61e-25 Alzheimer's disease; CESC cis rs7267005 0.661 rs2425099 chr20:34309643 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.9 -5.69 -0.33 3.35e-8 Response to paliperidone in schizophrenia (Multivariate); CESC cis rs7089973 0.604 rs7914792 chr10:116591391 T/C cg25233709 chr10:116636983 FAM160B1 0.38 5.9 0.34 1.12e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.75 0.47 2.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7647973 0.600 rs35174559 chr3:49287759 T/C cg07636037 chr3:49044803 WDR6 0.78 13.03 0.63 2.43e-30 Menarche (age at onset); CESC cis rs929354 0.742 rs7784442 chr7:156934475 G/C cg05182265 chr7:156933206 UBE3C -0.49 -7.04 -0.4 1.69e-11 Body mass index; CESC cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg22633769 chr20:60982531 CABLES2 -0.53 -5.5 -0.32 8.96e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs9291683 0.588 rs35866697 chr4:10018604 C/A cg02734326 chr4:10020555 SLC2A9 0.52 7.42 0.41 1.61e-12 Bone mineral density; CESC cis rs7937682 0.961 rs11601674 chr11:111634354 C/T cg09085632 chr11:111637200 PPP2R1B -1.09 -14.84 -0.67 1.15e-36 Primary sclerosing cholangitis; CESC cis rs9309473 1.000 rs7607014 chr2:73730174 C/T cg20560298 chr2:73613845 ALMS1 0.48 6.76 0.38 8.51e-11 Metabolite levels; CESC cis rs28647808 1.000 rs2285481 chr9:136271744 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs75804782 0.521 rs72982590 chr2:239451826 T/C cg18131467 chr2:239335373 ASB1 -0.68 -5.47 -0.32 1.04e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs11155671 0.530 rs1334510 chr6:150201179 A/G cg09699651 chr6:150184138 LRP11 0.57 7.73 0.43 2.21e-13 Testicular germ cell tumor; CESC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg24531977 chr5:56204891 C5orf35 -0.83 -11.11 -0.56 8.79e-24 Initial pursuit acceleration; CESC cis rs11792861 0.926 rs17729523 chr9:111773317 T/C cg13535736 chr9:111863775 C9orf5 -0.49 -6.42 -0.37 6.44e-10 Menarche (age at onset); CESC cis rs870825 0.616 rs4437295 chr4:185643336 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg06665941 chr21:34602869 IFNAR2 0.47 6.5 0.37 3.89e-10 Obesity-related traits; CESC cis rs6500395 0.775 rs13331298 chr16:48661489 G/A cg04672837 chr16:48644449 N4BP1 0.49 6.25 0.36 1.59e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7937682 0.921 rs4534611 chr11:111440425 C/G cg22437258 chr11:111473054 SIK2 0.6 7.22 0.41 5.47e-12 Primary sclerosing cholangitis; CESC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg11890956 chr21:40555474 PSMG1 1.2 22.3 0.81 9.49e-63 Cognitive function; CESC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg10053473 chr17:62856997 LRRC37A3 0.65 7.26 0.41 4.26e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4727027 0.866 rs3927307 chr7:148774869 C/T cg23158103 chr7:148848205 ZNF398 -0.4 -6.42 -0.37 6.38e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg03576123 chr11:487126 PTDSS2 -1.09 -10.84 -0.55 6.44e-23 Body mass index; CESC cis rs7582720 0.943 rs72926799 chr2:203828192 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.92 0.39 3.39e-11 Bipolar disorder; CESC trans rs11039798 0.545 rs7118670 chr11:48532056 C/T cg03929089 chr4:120376271 NA 0.61 6.02 0.35 5.81e-9 Axial length; CESC cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg18230493 chr5:56204884 C5orf35 0.61 7.97 0.44 4.79e-14 Initial pursuit acceleration; CESC cis rs561341 1.000 rs498391 chr17:30328704 G/A cg19193384 chr17:30244184 NA -0.62 -5.95 -0.34 8.48e-9 Hip circumference adjusted for BMI; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05666423 chr13:60970705 TDRD3 0.45 6.04 0.35 5.26e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9300255 0.679 rs4759420 chr12:123794871 G/C cg19016782 chr12:123741754 C12orf65 -0.43 -6.0 -0.35 6.54e-9 Neutrophil percentage of white cells; CESC cis rs3733585 0.631 rs4697924 chr4:10124239 A/G cg11266682 chr4:10021025 SLC2A9 -0.55 -9.43 -0.5 2.21e-18 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.13 -0.4 9.42e-12 Personality dimensions; CESC cis rs4654899 0.802 rs10916906 chr1:21255675 C/A cg05370193 chr1:21551575 ECE1 0.39 5.65 0.33 4.09e-8 Superior frontal gyrus grey matter volume; CESC cis rs9790314 0.521 rs13084746 chr3:161086038 G/A cg04691961 chr3:161091175 C3orf57 -0.37 -5.09 -0.3 6.66e-7 Morning vs. evening chronotype; CESC cis rs6570726 0.935 rs369458 chr6:145812809 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.49 0.37 4.31e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9815354 0.812 rs73071325 chr3:41809989 T/G cg03022575 chr3:42003672 ULK4 0.68 6.06 0.35 4.7e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg19163074 chr7:65112434 INTS4L2 -0.41 -5.11 -0.3 6.13e-7 Aortic root size; CESC cis rs2463822 0.925 rs1528730 chr11:62081181 A/C cg06239285 chr11:62104954 ASRGL1 0.94 8.82 0.48 1.61e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs3820068 0.581 rs3940061 chr1:15941276 C/T cg17385448 chr1:15911702 AGMAT 0.41 6.59 0.38 2.42e-10 Systolic blood pressure; CESC cis rs75804782 0.521 rs55657931 chr2:239422072 A/G cg18131467 chr2:239335373 ASB1 -0.68 -5.66 -0.33 3.87e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs35110281 0.805 rs2838330 chr21:45023876 T/A cg01579765 chr21:45077557 HSF2BP -0.61 -10.41 -0.54 1.7e-21 Mean corpuscular volume; CESC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg17143192 chr8:8559678 CLDN23 0.76 8.9 0.48 9.21e-17 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10015802 chr19:3492440 DOHH 0.51 7.15 0.4 8.62e-12 Fibrinogen levels; CESC cis rs7818345 0.935 rs6991212 chr8:19276522 C/T cg11303988 chr8:19266685 CSGALNACT1 0.32 5.85 0.34 1.45e-8 Language performance in older adults (adjusted for episodic memory); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg14887563 chr7:86849180 C7orf23 -0.43 -6.19 -0.36 2.32e-9 Breast cancer; CESC cis rs1048238 0.846 rs945420 chr1:16345208 G/A cg21214613 chr1:16344536 HSPB7 0.33 5.4 0.31 1.48e-7 Systolic blood pressure; CESC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.77 6.42 0.37 6.32e-10 Platelet count; CESC cis rs2742234 0.656 rs1864400 chr10:43610366 G/A cg07801480 chr10:43725741 RASGEF1A 0.43 5.61 0.33 5.14e-8 Hirschsprung disease; CESC cis rs6693567 0.545 rs1260391 chr1:150373077 T/C cg09579323 chr1:150459698 TARS2 0.48 5.98 0.34 7.23e-9 Migraine; CESC cis rs2239547 0.657 rs4687554 chr3:52864135 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.37 0.36 8.36e-10 Schizophrenia; CESC cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg16506815 chr2:162101123 NA -0.43 -5.9 -0.34 1.11e-8 Intelligence (multi-trait analysis); CESC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.14 -0.3 5.22e-7 Lung cancer; CESC cis rs1003719 0.680 rs767998 chr21:38525652 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.95 -0.44 5.41e-14 Eye color traits; CESC cis rs344364 0.511 rs1742464 chr16:1947335 A/G cg03013636 chr16:1946785 NA -0.47 -6.46 -0.37 5.05e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs3820068 0.705 rs57440988 chr1:15879034 T/C cg17385448 chr1:15911702 AGMAT 0.37 5.88 0.34 1.24e-8 Systolic blood pressure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09293122 chr7:99811980 GATS;STAG3 -0.4 -6.1 -0.35 3.68e-9 Gut microbiota (bacterial taxa); CESC cis rs863345 0.604 rs1342954 chr1:158464548 C/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC trans rs12915820 1 rs12915820 chr15:82009111 T/G cg07747791 chr7:27498134 NA -0.4 -6.02 -0.35 5.91e-9 Response to paliperidone in schizophrenia (PANSS score); CESC cis rs4642101 0.765 rs9871991 chr3:12827525 C/A cg24848339 chr3:12840334 CAND2 0.35 5.37 0.31 1.73e-7 QRS complex (12-leadsum); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02952972 chr11:972247 AP2A2 0.49 6.65 0.38 1.7e-10 Fibrinogen levels; CESC cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg13628971 chr7:2884303 GNA12 0.41 5.45 0.32 1.18e-7 Height; CESC cis rs477692 0.673 rs1078847 chr10:131352115 T/C cg05714579 chr10:131428358 MGMT 0.4 5.14 0.3 5.3e-7 Response to temozolomide; CESC cis rs1865721 0.958 rs11663060 chr18:73172806 T/C cg26385618 chr18:73139727 C18orf62 -0.44 -6.59 -0.38 2.3e-10 Intelligence; CESC cis rs7078219 0.505 rs11190140 chr10:101291593 T/C cg09788492 chr10:101292477 NKX2-3 0.33 6.18 0.35 2.45e-9 Dental caries; CESC cis rs2249625 0.504 rs2496508 chr6:72891398 A/G cg18830697 chr6:72922368 RIMS1 -0.47 -7.02 -0.4 1.89e-11 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs728616 0.867 rs75447386 chr10:81739647 G/A cg05935833 chr10:81318306 SFTPA2 -0.52 -5.06 -0.3 7.72e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs8067545 0.611 rs2107565 chr17:20088492 C/T cg13482628 chr17:19912719 NA -0.42 -5.74 -0.33 2.6e-8 Schizophrenia; CESC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg12463550 chr7:65579703 CRCP 0.63 5.98 0.34 7.1e-9 Diabetic kidney disease; CESC cis rs9467711 0.606 rs9379856 chr6:26366836 A/C cg14345882 chr6:26364793 BTN3A2 0.6 6.17 0.35 2.57e-9 Autism spectrum disorder or schizophrenia; CESC cis rs12765878 1.000 rs34300861 chr10:105643332 A/C cg11005552 chr10:105648138 OBFC1 0.35 5.1 0.3 6.34e-7 Coronary artery disease; CESC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg07701084 chr6:150067640 NUP43 0.44 5.99 0.35 6.96e-9 Lung cancer; CESC cis rs7216064 1.000 rs2052187 chr17:65834737 T/C cg12091567 chr17:66097778 LOC651250 -0.81 -9.18 -0.49 1.28e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18861140 chr18:3449789 TGIF1 -0.45 -6.05 -0.35 4.97e-9 Ulcerative colitis; CESC cis rs8072100 0.935 rs12150231 chr17:45717091 G/A cg08085267 chr17:45401833 C17orf57 0.42 5.54 0.32 7.25e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6430585 0.583 rs1435577 chr2:136624947 C/G cg07169764 chr2:136633963 MCM6 1.29 19.73 0.77 6.43e-54 Corneal structure; CESC cis rs7605827 0.866 rs11680706 chr2:15477375 T/C cg19274914 chr2:15703543 NA 0.31 5.53 0.32 7.75e-8 Educational attainment (years of education); CESC cis rs4474465 0.607 rs4945303 chr11:78283803 A/G cg27205649 chr11:78285834 NARS2 0.53 7.32 0.41 2.95e-12 Alzheimer's disease (survival time); CESC cis rs1215050 0.740 rs10025482 chr4:99053277 T/C cg17366294 chr4:99064904 C4orf37 0.44 5.81 0.34 1.78e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg15320075 chr8:145703422 NA -0.39 -5.29 -0.31 2.51e-7 Age at first birth; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07474076 chr16:2972993 FLYWCH1 0.46 6.14 0.35 2.97e-9 Fibrinogen levels; CESC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.66 -7.37 -0.41 2.23e-12 Gut microbiome composition (summer); CESC cis rs9916302 0.645 rs1053651 chr17:37822311 A/C cg20243544 chr17:37824526 PNMT 0.57 7.05 0.4 1.55e-11 Glomerular filtration rate (creatinine); CESC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs4919087 0.683 rs7074896 chr10:99071282 T/C cg25902810 chr10:99078978 FRAT1 -0.5 -5.62 -0.33 4.79e-8 Monocyte count; CESC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg18301423 chr5:131593218 PDLIM4 0.42 6.05 0.35 4.87e-9 Acylcarnitine levels; CESC trans rs17685 0.753 rs1859791 chr7:75786043 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.42 0.61 3.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.25e-7 Colorectal cancer; CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg18591801 chr3:52553433 STAB1 -0.29 -5.68 -0.33 3.59e-8 Electroencephalogram traits; CESC cis rs4604732 0.642 rs4400652 chr1:247636479 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.46 6.57 0.37 2.61e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11690935 0.879 rs13017585 chr2:172721808 C/A cg13550731 chr2:172543902 DYNC1I2 -0.97 -13.65 -0.64 1.68e-32 Schizophrenia; CESC cis rs4704187 0.687 rs4447960 chr5:74361857 C/A cg03227963 chr5:74354835 NA 0.31 5.69 0.33 3.36e-8 Response to amphetamines; CESC cis rs7267979 1.000 rs2500405 chr20:25360826 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -15.92 -0.7 1.72e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs854765 0.583 rs9904163 chr17:17830553 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.18 0.45 1.22e-14 Total body bone mineral density; CESC cis rs344364 0.511 rs1657144 chr16:1963989 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.59 -6.31 -0.36 1.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7809950 1.000 rs10258385 chr7:107243350 T/C cg23024343 chr7:107201750 COG5 0.46 6.32 0.36 1.11e-9 Coronary artery disease; CESC cis rs870825 0.616 rs6552810 chr4:185644143 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg17524854 chr12:67663046 CAND1 0.48 6.2 0.36 2.13e-9 Obesity-related traits; CESC cis rs2952156 0.920 rs903502 chr17:37829604 C/T cg00129232 chr17:37814104 STARD3 -0.81 -11.81 -0.59 3.71e-26 Asthma; CESC cis rs7937682 0.889 rs487985 chr11:111517908 G/A cg09085632 chr11:111637200 PPP2R1B -0.99 -16.01 -0.7 8.36e-41 Primary sclerosing cholangitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02145411 chr1:110528025 AHCYL1 -0.42 -6.2 -0.36 2.21e-9 Gambling; CESC cis rs61776719 0.520 rs11485595 chr1:38411350 C/T cg26398791 chr1:38455867 SF3A3 -0.41 -5.28 -0.31 2.73e-7 Coronary artery disease; CESC cis rs7267979 0.932 rs6107052 chr20:25530838 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.75 13.8 0.65 5.36e-33 Liver enzyme levels (alkaline phosphatase); CESC cis rs2629540 0.889 rs4962696 chr10:126445630 A/G cg08799069 chr10:126477246 METTL10 -0.66 -9.08 -0.49 2.49e-17 Cocaine dependence; CESC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg02807482 chr3:125708958 NA -0.4 -5.2 -0.3 3.94e-7 Blood pressure (smoking interaction); CESC trans rs11098499 0.954 rs12506546 chr4:120301618 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.16 0.49 1.46e-17 Corneal astigmatism; CESC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg04369109 chr6:150039330 LATS1 0.44 5.95 0.34 8.47e-9 Lung cancer; CESC cis rs478304 0.651 rs4930319 chr11:65555458 G/C cg27068330 chr11:65405492 SIPA1 -0.48 -5.74 -0.33 2.57e-8 Acne (severe); CESC cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.35 5.86 0.34 1.41e-8 Hemoglobin concentration; CESC cis rs7402982 0.525 rs11247361 chr15:99207392 C/G cg03437748 chr15:99193247 IGF1R -0.59 -7.99 -0.44 4.16e-14 Birth weight; CESC cis rs1538970 0.924 rs2088100 chr1:45877575 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.49 0.32 9.28e-8 Platelet count; CESC cis rs9399135 0.967 rs12526055 chr6:135325918 C/T cg24558204 chr6:135376177 HBS1L 0.51 6.94 0.39 3.08e-11 Red blood cell count; CESC cis rs9611565 0.512 rs5758465 chr22:42175314 T/C cg17376030 chr22:41985996 PMM1 -0.79 -8.37 -0.46 3.44e-15 Vitiligo; CESC cis rs12579753 0.917 rs12366599 chr12:82212112 C/T cg24719984 chr12:82153464 PPFIA2 -0.34 -5.07 -0.3 7.37e-7 Resting heart rate; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02718824 chr12:51442167 LETMD1 -0.47 -6.12 -0.35 3.3e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg24308560 chr3:49941425 MST1R -0.6 -8.81 -0.48 1.7e-16 Intelligence (multi-trait analysis); CESC cis rs698813 0.543 rs12468824 chr2:44482448 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.38 0.31 1.62e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs6693567 0.565 rs10888584 chr1:150476406 C/G cg09579323 chr1:150459698 TARS2 0.49 5.87 0.34 1.33e-8 Migraine; CESC cis rs225245 0.791 rs7406966 chr17:34013636 A/C cg05299278 chr17:33885742 SLFN14 0.38 5.42 0.32 1.32e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs709400 0.633 rs7160208 chr14:103965528 G/A cg12935359 chr14:103987150 CKB -0.52 -7.55 -0.42 7.22e-13 Body mass index; CESC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg06873352 chr17:61820015 STRADA 0.73 13.07 0.63 1.78e-30 Prudent dietary pattern; CESC cis rs8020095 0.571 rs10133107 chr14:67476864 C/G cg19548862 chr14:67692701 FAM71D -0.49 -6.09 -0.35 3.92e-9 Depression (quantitative trait); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01145475 chr6:7313460 SSR1 -0.5 -6.7 -0.38 1.26e-10 Fibrinogen levels; CESC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg03351412 chr1:154909251 PMVK 0.69 9.38 0.5 3.14e-18 Prostate cancer; CESC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg10792982 chr14:105748885 BRF1 0.4 5.22 0.31 3.7e-7 Mean platelet volume;Platelet distribution width; CESC cis rs722599 0.683 rs7145246 chr14:75242394 A/T cg11812906 chr14:75593930 NEK9 -0.45 -5.51 -0.32 8.48e-8 IgG glycosylation; CESC cis rs6963495 0.818 rs6961863 chr7:105180953 C/T cg13798780 chr7:105162888 PUS7 0.75 8.34 0.46 4.18e-15 Bipolar disorder (body mass index interaction); CESC cis rs6582630 0.519 rs12368889 chr12:38315160 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.21 0.53 7.66e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs2841277 0.676 rs4264326 chr14:105411700 A/G cg14403583 chr14:105418241 AHNAK2 -0.58 -8.11 -0.45 1.91e-14 Rheumatoid arthritis; CESC cis rs7666738 0.830 rs1426670 chr4:98923572 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.37e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg18225595 chr11:63971243 STIP1 0.52 5.29 0.31 2.54e-7 Mean platelet volume; CESC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg22638593 chr5:131593259 PDLIM4 0.41 5.33 0.31 2.15e-7 Breast cancer; CESC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg12648201 chr2:27665141 KRTCAP3 -0.36 -6.62 -0.38 1.93e-10 Total body bone mineral density; CESC cis rs1153858 1.000 rs1820518 chr15:45694579 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 5.88 0.34 1.22e-8 Homoarginine levels; CESC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg15352829 chr14:105391018 PLD4 -0.59 -10.1 -0.53 1.69e-20 Rheumatoid arthritis; CESC cis rs1483890 0.642 rs6795775 chr3:69402801 C/T cg22125112 chr3:69402811 FRMD4B 0.39 5.26 0.31 2.98e-7 Resting heart rate; CESC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.63 8.03 0.44 3.13e-14 Height; CESC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 6.47 0.37 4.65e-10 LDL cholesterol;Cholesterol, total; CESC trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg15556689 chr8:8085844 FLJ10661 -0.55 -6.94 -0.39 3.02e-11 Neuroticism; CESC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg09877947 chr5:131593287 PDLIM4 0.47 6.26 0.36 1.56e-9 Breast cancer; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg02493798 chr17:6899577 ALOX12 0.42 7.38 0.41 2.04e-12 Tonsillectomy; CESC cis rs17666538 0.792 rs1703912 chr8:600643 A/G cg02524346 chr8:600233 NA 0.81 6.36 0.36 8.74e-10 IgG glycosylation; CESC cis rs3008870 1.000 rs4620509 chr1:67449941 A/G cg02640540 chr1:67518911 SLC35D1 -0.51 -5.52 -0.32 7.96e-8 Lymphocyte percentage of white cells; CESC cis rs13064411 0.696 rs7622740 chr3:113206771 G/A cg18753928 chr3:113234510 CCDC52 -0.48 -5.62 -0.33 4.91e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs8014204 0.935 rs2300596 chr14:75353855 C/T cg26191576 chr14:75389716 RPS6KL1 -0.35 -5.07 -0.3 7.58e-7 Caffeine consumption; CESC cis rs72781680 0.898 rs2879640 chr2:24043573 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg02487422 chr3:49467188 NICN1 0.39 5.08 0.3 7.18e-7 Parkinson's disease; CESC cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg05347473 chr6:146136440 FBXO30 0.56 7.11 0.4 1.06e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.38 5.28 0.31 2.65e-7 Lymphocyte counts; CESC cis rs9790314 0.503 rs6441374 chr3:161064540 A/T cg03342759 chr3:160939853 NMD3 -0.5 -7.3 -0.41 3.29e-12 Morning vs. evening chronotype; CESC cis rs12318506 0.793 rs71460129 chr12:75699427 C/T cg04728562 chr12:75699417 CAPS2 -1.19 -8.39 -0.46 2.98e-15 Coronary artery calcification; CESC cis rs1953600 0.837 rs2573352 chr10:81939813 T/C cg00277334 chr10:82204260 NA 0.45 6.28 0.36 1.39e-9 Sarcoidosis; CESC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg25072359 chr17:41440525 NA 0.51 6.62 0.38 1.95e-10 Menopause (age at onset); CESC cis rs2070433 0.534 rs2839269 chr21:47891491 A/G cg12379764 chr21:47803548 PCNT 0.44 5.55 0.32 6.98e-8 Lymphocyte counts; CESC cis rs2075671 0.855 rs11974395 chr7:100282538 G/A cg20848291 chr7:100343083 ZAN -0.8 -10.16 -0.53 1.09e-20 Other erythrocyte phenotypes; CESC cis rs6831352 0.589 rs1133483 chr4:100023923 G/C cg13256891 chr4:100009986 ADH5 0.7 9.86 0.52 9.41e-20 Alcohol dependence; CESC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Depression; CESC cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg05283184 chr6:79620031 NA -0.41 -6.2 -0.36 2.1e-9 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04662649 chr15:41191689 VPS18 0.46 6.64 0.38 1.79e-10 Fibrinogen levels; CESC cis rs66887589 1.000 rs66887589 chr4:120509279 T/C cg09307838 chr4:120376055 NA -0.54 -7.17 -0.4 7.62e-12 Diastolic blood pressure; CESC cis rs921665 0.748 rs11677991 chr2:3185321 G/A cg00496484 chr2:3153332 NA -0.46 -5.03 -0.3 9.09e-7 World class endurance athleticism; CESC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.76 9.49 0.5 1.41e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs3096299 0.967 rs753852 chr16:89446419 G/A cg16743903 chr16:89593216 SPG7 -0.46 -5.85 -0.34 1.43e-8 Multiple myeloma (IgH translocation); CESC cis rs6005807 0.543 rs2235432 chr22:29169420 T/G cg02153584 chr22:29168773 CCDC117 0.48 5.03 0.3 8.98e-7 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; CESC cis rs561341 0.714 rs547473 chr17:30297560 T/G cg12193833 chr17:30244370 NA -0.59 -6.02 -0.35 5.78e-9 Hip circumference adjusted for BMI; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00252696 chr1:31769601 ZCCHC17;SNRNP40 -0.47 -6.38 -0.36 7.75e-10 Ulcerative colitis; CESC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg09491104 chr22:46646882 C22orf40 -0.49 -5.96 -0.34 8.16e-9 LDL cholesterol;Cholesterol, total; CESC cis rs72945132 0.882 rs7950916 chr11:70210001 T/C cg14191688 chr11:70257035 CTTN 0.41 5.12 0.3 6.02e-7 Coronary artery disease; CESC cis rs10752881 1.000 rs4233193 chr1:182970865 C/T ch.1.3577855R chr1:183094577 LAMC1 0.85 13.67 0.64 1.54e-32 Colorectal cancer; CESC cis rs6582630 0.502 rs2204008 chr12:38439203 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.09 0.53 1.86e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg06494592 chr3:125709126 NA -0.46 -5.27 -0.31 2.78e-7 Blood pressure (smoking interaction); CESC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg24060327 chr5:131705240 SLC22A5 -0.44 -5.3 -0.31 2.41e-7 Blood metabolite levels; CESC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.05 0.4 1.57e-11 Height; CESC cis rs3857536 0.813 rs2093253 chr6:66937702 A/G cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs10752881 0.967 rs10911186 chr1:182972542 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 13.45 0.64 8.93e-32 Colorectal cancer; CESC trans rs61931739 0.517 rs11053224 chr12:34484919 G/A cg13010199 chr12:38710504 ALG10B 0.49 6.18 0.35 2.41e-9 Morning vs. evening chronotype; CESC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 13.61 0.64 2.33e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs478304 0.651 rs12225620 chr11:65505448 T/C cg10518572 chr11:65560635 OVOL1 -0.32 -6.19 -0.36 2.31e-9 Acne (severe); CESC cis rs761746 0.593 rs2387 chr22:31977874 T/C cg25791279 chr22:32026902 PISD -0.59 -5.94 -0.34 8.91e-9 Intelligence; CESC cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg23711669 chr6:146136114 FBXO30 0.97 14.47 0.66 2.25e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs1048238 0.506 rs698889 chr1:16267040 A/C cg22431228 chr1:16359049 CLCNKA 0.37 6.24 0.36 1.76e-9 Systolic blood pressure; CESC cis rs75477785 1.000 rs17015268 chr1:209988989 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 -0.84 -5.68 -0.33 3.51e-8 Cleft lip with or without cleft palate; CESC cis rs11098499 0.955 rs11931312 chr4:120159023 T/C cg09307838 chr4:120376055 NA 0.86 11.43 0.57 7.37e-25 Corneal astigmatism; CESC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg07936489 chr17:37558343 FBXL20 -0.82 -12.0 -0.59 8.91e-27 Glomerular filtration rate (creatinine); CESC trans rs1973993 0.507 rs2759670 chr1:97002864 A/G cg10631902 chr5:14652156 NA 0.46 6.89 0.39 4.05e-11 Weight; CESC cis rs35110281 0.774 rs141521 chr21:44963686 G/A cg01579765 chr21:45077557 HSF2BP -0.57 -9.83 -0.52 1.19e-19 Mean corpuscular volume; CESC cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs367943 0.966 rs444322 chr5:112815399 C/T cg12552261 chr5:112820674 MCC -0.62 -7.78 -0.43 1.58e-13 Type 2 diabetes; CESC cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg25405998 chr7:65216604 CCT6P1 0.51 5.52 0.32 8.13e-8 Aortic root size; CESC cis rs2251381 0.750 rs8129616 chr21:30520085 C/T cg08807101 chr21:30365312 RNF160 -0.74 -9.29 -0.5 5.68e-18 Selective IgA deficiency; CESC cis rs2952156 0.959 rs2934952 chr17:37832366 G/A cg07936489 chr17:37558343 FBXL20 -0.55 -6.66 -0.38 1.56e-10 Asthma; CESC cis rs9488822 0.676 rs7774952 chr6:116380909 A/G cg18764771 chr6:116381957 FRK 0.23 5.87 0.34 1.28e-8 Cholesterol, total;LDL cholesterol; CESC cis rs75477785 0.590 rs10863800 chr1:210123774 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.94 6.76 0.38 8.97e-11 Cleft lip with or without cleft palate; CESC trans rs9354352 0.818 rs9453548 chr6:66691885 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.63 -8.98 -0.48 5.18e-17 Initial pursuit acceleration in psychotic disorders; CESC cis rs7267979 1.000 rs6050590 chr20:25384994 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.39e-48 Liver enzyme levels (alkaline phosphatase); CESC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg01341218 chr17:43662625 NA -0.55 -7.49 -0.42 1.02e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04908325 chr14:74353526 ZNF410 -0.48 -6.06 -0.35 4.59e-9 Ulcerative colitis; CESC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg25517755 chr10:38738941 LOC399744 -0.45 -5.73 -0.33 2.79e-8 Extrinsic epigenetic age acceleration; CESC cis rs79349575 0.756 rs937301 chr17:47046276 A/G cg16584676 chr17:46985605 UBE2Z -0.45 -5.51 -0.32 8.49e-8 Type 2 diabetes; CESC trans rs1545843 0.593 rs11495253 chr12:84799698 A/G cg03015433 chr16:56623111 MT3 -0.34 -6.14 -0.35 3.04e-9 Major depressive disorder; CESC cis rs7568498 0.564 rs9287807 chr2:161915361 T/C cg08807892 chr2:162101083 NA -0.54 -5.86 -0.34 1.38e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs2011503 1.000 rs78176666 chr19:19636702 T/C cg11584989 chr19:19387371 SF4 0.61 7.03 0.4 1.79e-11 Bipolar disorder; CESC cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg04455712 chr21:45112962 RRP1B 0.52 8.12 0.45 1.78e-14 Mean corpuscular volume; CESC cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg16447950 chr5:562315 NA -0.62 -6.52 -0.37 3.54e-10 Lung disease severity in cystic fibrosis; CESC cis rs7188697 0.922 rs4471670 chr16:58601365 G/A cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC trans rs7726839 0.794 rs11739663 chr5:594083 A/G cg25482853 chr8:67687455 SGK3 0.62 6.44 0.37 5.58e-10 Obesity-related traits; CESC cis rs2066819 1.000 rs76466034 chr12:56719450 G/A cg26804944 chr12:56660921 COQ10A -0.85 -5.14 -0.3 5.39e-7 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06531661 chr12:57522120 LRP1 0.55 6.2 0.36 2.2e-9 Gut microbiome composition (summer); CESC trans rs10905099 0.708 rs7080182 chr10:7097117 A/G cg05230642 chr15:25439252 SNORD115-14 -0.73 -6.17 -0.35 2.6e-9 Orofacial clefts; CESC cis rs1670533 1.000 rs7669622 chr4:1058659 A/G cg04106633 chr4:1044584 NA 0.42 5.36 0.31 1.84e-7 Recombination rate (females); CESC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg17971929 chr21:40555470 PSMG1 -0.6 -7.92 -0.44 6.45e-14 Menarche (age at onset); CESC cis rs6429082 0.755 rs291384 chr1:235644300 C/T cg26050004 chr1:235667680 B3GALNT2 0.62 7.88 0.44 8.78e-14 Adiposity; CESC cis rs7116495 1.000 rs2298457 chr11:71734211 T/C cg10381502 chr11:71823885 C11orf51 -0.64 -5.21 -0.3 3.81e-7 Severe influenza A (H1N1) infection; CESC cis rs4242434 0.854 rs3064 chr8:22451688 C/G cg03733263 chr8:22462867 KIAA1967 -0.84 -13.4 -0.64 1.32e-31 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs798766 1.000 rs1374469 chr4:1724799 C/T cg07041428 chr4:1763019 NA -0.38 -5.03 -0.3 8.86e-7 Bladder cancer;Urinary bladder cancer; CESC cis rs3806933 0.522 rs13179305 chr5:110444474 G/A cg04022379 chr5:110408740 TSLP 0.46 7.41 0.41 1.71e-12 Eosinophilic esophagitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23045373 chr8:11324048 FAM167A 0.68 8.48 0.46 1.64e-15 Gut microbiome composition (summer); CESC cis rs2832191 0.791 rs2832182 chr21:30481612 G/A cg24692254 chr21:30365293 RNF160 -0.8 -12.52 -0.61 1.4e-28 Dental caries; CESC cis rs7617773 0.851 rs6775179 chr3:48313418 T/C cg11946769 chr3:48343235 NME6 0.8 10.74 0.55 1.38e-22 Coronary artery disease; CESC cis rs6540559 0.673 rs6698154 chr1:210007777 A/G cg25204440 chr1:209979598 IRF6 0.59 5.91 0.34 1.05e-8 Cleft lip with or without cleft palate; CESC cis rs9811920 0.529 rs793442 chr3:99581062 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.38 5.22 0.31 3.56e-7 Axial length; CESC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg05234568 chr11:5960015 NA -0.6 -8.54 -0.46 1.04e-15 DNA methylation (variation); CESC cis rs7666738 0.830 rs7672127 chr4:98938477 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.86 0.34 1.35e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6973256 0.605 rs10227672 chr7:133326196 G/C cg10665199 chr7:133106180 EXOC4 -0.42 -5.55 -0.32 6.85e-8 Intelligence (multi-trait analysis); CESC cis rs6547741 1.000 rs6547740 chr2:27854369 C/T cg27432699 chr2:27873401 GPN1 0.44 6.12 0.35 3.36e-9 Oral cavity cancer; CESC cis rs7647973 0.807 rs4955416 chr3:49108428 T/C cg07636037 chr3:49044803 WDR6 0.89 13.08 0.63 1.67e-30 Menarche (age at onset); CESC cis rs2415984 0.622 rs7156444 chr14:46933296 C/G cg14871534 chr14:47121158 RPL10L -0.34 -5.12 -0.3 5.96e-7 Number of children ever born; CESC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg06028605 chr16:24865363 SLC5A11 -0.54 -8.07 -0.44 2.39e-14 Intelligence (multi-trait analysis); CESC cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg05347473 chr6:146136440 FBXO30 0.57 7.21 0.4 5.99e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9911578 0.967 rs2611781 chr17:56703124 C/G cg12560992 chr17:57184187 TRIM37 0.91 15.28 0.68 3.04e-38 Intelligence (multi-trait analysis); CESC cis rs3981351 0.797 rs34394259 chr10:115441082 A/G cg24846397 chr10:115438155 CASP7 -0.35 -5.08 -0.3 7.18e-7 Obesity-related traits; CESC cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg15541040 chr2:3486749 NA -0.43 -5.48 -0.32 1.01e-7 Neurofibrillary tangles; CESC cis rs4924935 0.748 rs9915894 chr17:18752778 T/C cg26378065 chr17:18585709 ZNF286B 0.49 5.33 0.31 2.11e-7 Pancreatic cancer; CESC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.33 0.41 2.75e-12 Tonsillectomy; CESC cis rs56346965 0.967 rs1978273 chr2:191532039 G/A cg27211696 chr2:191398769 TMEM194B -0.42 -5.53 -0.32 7.69e-8 Bone mineral density (Ward's triangle area); CESC cis rs595982 0.501 rs112370206 chr19:49396623 C/T cg21252483 chr19:49399788 TULP2 -0.38 -5.57 -0.32 6.41e-8 Red cell distribution width; CESC cis rs763121 0.853 rs138706 chr22:39137834 C/G cg14440974 chr22:39074834 NA -0.36 -5.16 -0.3 4.83e-7 Menopause (age at onset); CESC cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg02079420 chr8:82753780 SNX16 -0.53 -8.2 -0.45 1.01e-14 Diastolic blood pressure; CESC cis rs1538970 0.851 rs2055145 chr1:45926495 C/G cg24296786 chr1:45957014 TESK2 -0.46 -5.22 -0.31 3.61e-7 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25300805 chr2:183988933 NUP35 -0.59 -6.48 -0.37 4.51e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs9282681 chr16:89805914 T/C cg00800038 chr16:89945340 TCF25 -0.8 -6.47 -0.37 4.83e-10 Skin colour saturation; CESC cis rs6991838 0.584 rs16932250 chr8:66511014 T/G cg13398993 chr8:66546079 ARMC1 -0.47 -5.59 -0.32 5.56e-8 Intelligence (multi-trait analysis); CESC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg00431813 chr7:1051703 C7orf50 -0.35 -5.39 -0.31 1.59e-7 Longevity;Endometriosis; CESC cis rs68170813 0.599 rs6466162 chr7:106902625 C/T cg02696742 chr7:106810147 HBP1 -0.53 -5.16 -0.3 4.75e-7 Coronary artery disease; CESC cis rs9393692 0.620 rs9379842 chr6:26289310 C/T cg13736514 chr6:26305472 NA 0.33 5.55 0.32 6.97e-8 Educational attainment; CESC cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg11644478 chr21:40555479 PSMG1 1.05 16.51 0.71 1.32e-42 Cognitive function; CESC cis rs9611565 0.512 rs5758464 chr22:42171300 A/G cg06634786 chr22:41940651 POLR3H 0.67 5.74 0.33 2.6e-8 Vitiligo; CESC cis rs4891159 0.526 rs2848961 chr18:74129886 C/G cg24786174 chr18:74118243 ZNF516 -0.85 -15.83 -0.7 3.64e-40 Longevity; CESC cis rs2732480 0.577 rs2732481 chr12:48736985 T/G cg04545296 chr12:48745243 ZNF641 0.44 7.22 0.41 5.44e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg23161317 chr6:28129485 ZNF389 0.47 5.89 0.34 1.18e-8 Depression; CESC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg12516959 chr21:47718080 NA -0.47 -6.38 -0.37 7.68e-10 Testicular germ cell tumor; CESC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg27170947 chr2:26402098 FAM59B 0.75 8.39 0.46 3.03e-15 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20710888 chr6:87865238 ZNF292 0.61 6.78 0.38 8.01e-11 Gut microbiome composition (summer); CESC cis rs793571 0.590 rs17190727 chr15:59073790 C/A cg05156742 chr15:59063176 FAM63B 0.62 8.24 0.45 8.12e-15 Schizophrenia; CESC cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg11812906 chr14:75593930 NEK9 0.53 6.75 0.38 9.54e-11 Caffeine consumption; CESC cis rs62408225 1.000 rs62408224 chr6:90955995 A/G cg06866423 chr6:90926672 BACH2 0.44 5.34 0.31 2.01e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7799006 0.657 rs10447540 chr7:2301484 A/G cg12745145 chr7:2261452 MAD1L1 -0.33 -5.22 -0.31 3.56e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg00149659 chr3:10157352 C3orf10 0.73 8.89 0.48 9.97e-17 Alzheimer's disease; CESC cis rs854765 0.647 rs854767 chr17:18018263 A/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.45 -5.65 -0.33 4.13e-8 Total body bone mineral density; CESC cis rs7589342 0.929 rs6719896 chr2:106428404 C/G cg16077055 chr2:106428750 NCK2 -0.55 -7.9 -0.44 7.3e-14 Addiction; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07148452 chr15:90176987 KIF7 -0.49 -6.14 -0.35 3.05e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.84 -12.08 -0.6 4.61e-27 Alzheimer's disease; CESC cis rs9443645 0.901 rs1572584 chr6:79690290 A/G cg05283184 chr6:79620031 NA 0.39 6.04 0.35 5.15e-9 Intelligence (multi-trait analysis); CESC cis rs754466 0.606 rs11002309 chr10:79594931 C/T cg17075019 chr10:79541650 NA -0.87 -13.77 -0.65 6.64e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg24296786 chr1:45957014 TESK2 0.62 8.16 0.45 1.32e-14 High light scatter reticulocyte count; CESC trans rs7246657 0.943 rs7255952 chr19:37988797 A/G cg01833234 chr11:6592585 DNHD1 0.52 6.03 0.35 5.47e-9 Coronary artery calcification; CESC cis rs9611565 0.546 rs132793 chr22:42063681 A/G cg06481639 chr22:41940642 POLR3H 0.59 5.83 0.34 1.57e-8 Vitiligo; CESC cis rs7818688 1.000 rs28477467 chr8:96032905 G/A cg16049864 chr8:95962084 TP53INP1 0.59 5.77 0.33 2.17e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1003719 0.788 rs3787782 chr21:38462909 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC trans rs17764205 0.777 rs112570652 chr19:3255789 G/A cg02013146 chr16:89452259 ANKRD11 -0.77 -6.01 -0.35 6.15e-9 Bipolar disorder and schizophrenia; CESC cis rs2180341 0.960 rs9401952 chr6:127677027 A/C cg27446573 chr6:127587934 RNF146 1.06 15.88 0.7 2.39e-40 Breast cancer; CESC cis rs9614461 0.609 rs9614653 chr22:45767391 A/G cg13318129 chr22:45737514 FAM118A -0.51 -5.74 -0.33 2.6e-8 Tonsillectomy; CESC cis rs36051895 0.658 rs10815145 chr9:5013309 G/A cg02405213 chr9:5042618 JAK2 -0.44 -5.36 -0.31 1.81e-7 Pediatric autoimmune diseases; CESC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg11965913 chr1:205819406 PM20D1 0.45 6.27 0.36 1.42e-9 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs12999616 1.000 rs12999616 chr2:98324381 C/T cg26665480 chr2:98280029 ACTR1B 0.61 6.01 0.35 5.98e-9 Colorectal cancer; CESC cis rs10911363 0.549 rs12742245 chr1:183446922 T/A cg09173681 chr1:183549694 NCF2 0.51 7.27 0.41 4.04e-12 Systemic lupus erythematosus; CESC cis rs10208940 0.920 rs7423646 chr2:68758180 A/G cg12452813 chr2:68675892 NA 0.51 5.1 0.3 6.39e-7 Urate levels in lean individuals; CESC cis rs2108622 0.701 rs3093209 chr19:15988420 G/C cg13772218 chr19:15982569 NA 0.31 5.86 0.34 1.34e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.3.2442921F chr3:124726246 HEG1 -0.46 -6.14 -0.35 2.96e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11920090 0.860 rs11720145 chr3:170739663 G/A cg09710316 chr3:170744871 SLC2A2 0.42 5.04 0.3 8.74e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs796364 0.806 rs4673634 chr2:200863349 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 7.68 0.43 3.06e-13 Schizophrenia; CESC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg22105103 chr4:187893119 NA 0.44 6.04 0.35 5.29e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg08859206 chr1:53392774 SCP2 -0.71 -10.78 -0.55 1.02e-22 Monocyte count; CESC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg16590910 chr6:42928470 GNMT 0.38 5.4 0.32 1.46e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4662945 0.737 rs4662950 chr2:130238492 A/G cg05962382 chr2:130345044 NA -0.4 -5.88 -0.34 1.24e-8 Response to cytidine analogues (gemcitabine); CESC cis rs9549367 0.673 rs3024735 chr13:113819513 G/A cg00898013 chr13:113819073 PROZ -0.49 -6.59 -0.38 2.4e-10 Platelet distribution width; CESC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.64 0.38 1.73e-10 Bipolar disorder; CESC cis rs62064224 0.714 rs11657299 chr17:30634951 G/A cg18200150 chr17:30822561 MYO1D 0.39 5.24 0.31 3.28e-7 Schizophrenia; CESC trans rs13189969 0.506 rs1608636 chr5:105320427 A/T cg18251612 chr20:39318137 MAFB -0.46 -6.03 -0.35 5.47e-9 Obesity-related traits; CESC cis rs8018808 0.935 rs12433766 chr14:77930293 C/T cg20045696 chr14:77926864 AHSA1 0.43 5.9 0.34 1.13e-8 Myeloid white cell count; CESC cis rs1215050 0.791 rs7681599 chr4:98664109 C/T cg05340658 chr4:99064831 C4orf37 -0.47 -6.04 -0.35 5.08e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg23978390 chr7:1156363 C7orf50 0.45 5.93 0.34 9.44e-9 Longevity;Endometriosis; CESC cis rs34375054 0.624 rs7132026 chr12:125678096 A/G cg25124228 chr12:125621409 AACS 0.47 5.43 0.32 1.3e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs4704187 0.663 rs17738989 chr5:74533730 C/T cg03227963 chr5:74354835 NA 0.27 5.04 0.3 8.67e-7 Response to amphetamines; CESC cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg05283184 chr6:79620031 NA -0.41 -6.34 -0.36 9.66e-10 Intelligence (multi-trait analysis); CESC cis rs9894429 1.000 rs7222241 chr17:79574714 C/G cg13777783 chr17:79615861 NA -0.36 -6.07 -0.35 4.5e-9 Eye color traits; CESC cis rs6460942 0.915 rs10267801 chr7:12451931 G/A cg20607287 chr7:12443886 VWDE -0.65 -8.59 -0.47 7.51e-16 Coronary artery disease; CESC cis rs3820928 1.000 rs4675119 chr2:227774635 A/C cg11843606 chr2:227700838 RHBDD1 -0.39 -5.27 -0.31 2.83e-7 Pulmonary function; CESC cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg11812906 chr14:75593930 NEK9 -0.84 -13.95 -0.65 1.57e-33 Height; CESC cis rs941408 0.515 rs2110118 chr19:2775144 T/C cg06609049 chr19:2785107 THOP1 0.86 13.26 0.63 3.86e-31 Total cholesterol levels; CESC cis rs9435341 0.826 rs1730858 chr1:107619244 T/C cg09367891 chr1:107599246 PRMT6 -0.71 -8.44 -0.46 2.13e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs5769765 1.000 rs5769764 chr22:50270784 G/A cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs8060686 0.563 rs118005841 chr16:68157562 A/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.05 -0.35 4.9e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs3820928 1.000 rs4675115 chr2:227769123 C/G cg05526886 chr2:227700861 RHBDD1 -0.42 -5.31 -0.31 2.33e-7 Pulmonary function; CESC cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg17366294 chr4:99064904 C4orf37 0.62 8.88 0.48 1.03e-16 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg08736216 chr1:53307985 ZYG11A -0.4 -6.61 -0.38 2.09e-10 Monocyte count; CESC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.65 0.38 1.62e-10 Bipolar disorder; CESC cis rs1707322 1.000 rs7527079 chr1:46413450 C/G cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs636291 0.500 rs655271 chr1:10536635 G/A cg20482658 chr1:10539492 PEX14 -0.29 -6.05 -0.35 5.04e-9 Prostate cancer; CESC cis rs853679 0.599 rs13193295 chr6:28003228 C/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 5.58 0.32 6.06e-8 Depression; CESC cis rs425277 1.000 rs262641 chr1:2104981 C/T cg16545954 chr1:2118288 C1orf86 -0.34 -6.17 -0.35 2.49e-9 Height; CESC cis rs796364 0.755 rs203762 chr2:200905136 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.92 -0.44 6.51e-14 Schizophrenia; CESC cis rs34172651 0.583 rs4787649 chr16:24700215 C/T cg06505273 chr16:24850292 NA -0.45 -5.6 -0.33 5.3e-8 Intelligence (multi-trait analysis); CESC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg16680214 chr1:154839983 KCNN3 -0.44 -6.79 -0.38 7.4e-11 Prostate cancer; CESC cis rs8067545 0.578 rs4925091 chr17:20066988 T/C cg13482628 chr17:19912719 NA 0.41 5.46 0.32 1.1e-7 Schizophrenia; CESC cis rs3741489 1.000 rs3741489 chr12:133417802 A/G cg01499426 chr12:133417423 CHFR 0.87 5.43 0.32 1.28e-7 Cognitive function; CESC cis rs13064411 0.696 rs9839921 chr3:113199093 G/C cg18753928 chr3:113234510 CCDC52 -0.52 -6.32 -0.36 1.08e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs3785574 0.743 rs2727334 chr17:61969063 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.6 7.28 0.41 3.77e-12 Height; CESC cis rs644148 0.967 rs613876 chr19:44968788 T/C cg15540054 chr19:45004280 ZNF180 -0.72 -8.78 -0.47 2e-16 Personality dimensions; CESC cis rs362272 0.505 rs60208975 chr4:3364530 A/G cg08886695 chr4:3369023 RGS12 -0.45 -6.23 -0.36 1.77e-9 Serum sulfate level; CESC cis rs11711311 0.955 rs12634241 chr3:113397685 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.53 6.58 0.37 2.54e-10 IgG glycosylation; CESC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg08470875 chr2:26401718 FAM59B -0.73 -7.98 -0.44 4.43e-14 Gut microbiome composition (summer); CESC cis rs7520050 0.751 rs2230657 chr1:46073489 G/A cg03146154 chr1:46216737 IPP -0.56 -7.22 -0.41 5.38e-12 Red blood cell count;Reticulocyte count; CESC cis rs116095464 0.558 rs7356696 chr5:284251 A/G cg10591111 chr5:226296 SDHA -0.53 -6.43 -0.37 6.03e-10 Breast cancer; CESC cis rs10789491 1.000 rs1440487 chr1:47167075 C/T cg15501359 chr1:47185051 KIAA0494 -0.79 -8.75 -0.47 2.58e-16 Response to hepatitis C treatment; CESC cis rs9399135 0.935 rs4445070 chr6:135309212 C/T cg22676075 chr6:135203613 NA 0.51 7.02 0.4 1.92e-11 Red blood cell count; CESC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg01874867 chr7:94954059 PON1 -0.34 -5.5 -0.32 8.83e-8 Paraoxonase activity; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg25649261 chr6:138725556 HEBP2 0.45 6.08 0.35 4.17e-9 Psoriatic arthritis; CESC cis rs412050 0.502 rs17759796 chr22:22190163 A/C cg17089214 chr22:22089827 YPEL1 -0.7 -5.96 -0.34 8.21e-9 Attention deficit hyperactivity disorder; CESC cis rs11608355 0.618 rs4486687 chr12:109790741 T/A cg19025524 chr12:109796872 NA -0.53 -7.74 -0.43 2.11e-13 Neuroticism; CESC cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg13298116 chr11:62369859 EML3;MTA2 0.67 10.06 0.53 2.22e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.64 7.85 0.43 1.07e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.69 0.33 3.37e-8 Bipolar disorder; CESC cis rs1371867 0.846 rs1660345 chr8:101322762 C/A cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.1e-11 Atrioventricular conduction; CESC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg04315214 chr1:2043799 PRKCZ 0.53 9.3 0.5 5.38e-18 Height; CESC cis rs2204008 0.774 rs7305085 chr12:38263511 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.17 0.53 1.01e-20 Bladder cancer; CESC cis rs7119 0.717 rs11629835 chr15:77787469 G/T cg17802220 chr15:77601643 NA -0.51 -7.18 -0.4 7.24e-12 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17121955 chr11:6411382 SMPD1 0.62 7.41 0.41 1.72e-12 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs1701750 chr7:65467145 T/C cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC cis rs1707322 1.000 rs10789479 chr1:46352500 T/C cg03146154 chr1:46216737 IPP 0.78 10.75 0.55 1.29e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11958404 0.932 rs72816595 chr5:157435957 A/G cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs12142240 0.698 rs58162700 chr1:46816659 T/A cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg18404041 chr3:52824283 ITIH1 -0.45 -7.37 -0.41 2.14e-12 Bipolar disorder; CESC cis rs7917772 0.636 rs4919674 chr10:104522226 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.1 0.3 6.41e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs5757676 1.000 rs5757676 chr22:39841700 T/C cg02038168 chr22:39784481 NA -0.63 -6.5 -0.37 3.86e-10 IgG glycosylation; CESC cis rs6740322 0.895 rs6544643 chr2:43560072 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.72 -7.72 -0.43 2.45e-13 Coronary artery disease; CESC cis rs9467711 0.606 rs9379900 chr6:26603811 A/C cg12826209 chr6:26865740 GUSBL1 0.66 5.86 0.34 1.4e-8 Autism spectrum disorder or schizophrenia; CESC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg18446336 chr7:2847575 GNA12 -0.4 -6.02 -0.35 5.75e-9 Height; CESC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg26839252 chr6:160211577 TCP1;MRPL18 0.46 5.26 0.31 3.04e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.3 0.31 2.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11822910 0.737 rs2729389 chr11:57211646 A/G cg00522883 chr11:57194120 SLC43A3 -0.55 -7.23 -0.41 5.13e-12 Platelet distribution width; CESC cis rs12050794 0.671 rs62022788 chr15:72559326 T/G cg16672083 chr15:72433130 SENP8 0.42 6.22 0.36 1.94e-9 Metabolite levels (HVA/MHPG ratio); CESC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg22920501 chr2:26401640 FAM59B -0.79 -9.6 -0.51 6.47e-19 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg22800045 chr5:56110881 MAP3K1 0.73 9.21 0.49 1e-17 Initial pursuit acceleration; CESC cis rs6493487 0.512 rs11854729 chr15:51249128 T/C cg02338191 chr15:51200825 AP4E1 0.63 5.86 0.34 1.39e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.63 0.42 4.23e-13 Prudent dietary pattern; CESC trans rs11989744 0.957 rs57291069 chr8:23570211 G/T cg03492747 chr16:86543808 FOXF1 0.65 7.48 0.42 1.1e-12 Waist-hip ratio; CESC cis rs8103278 1.000 rs7252126 chr19:46302374 T/A cg12641515 chr19:46296257 DMWD -0.53 -5.83 -0.34 1.6e-8 Coronary artery disease; CESC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg24675658 chr1:53192096 ZYG11B -0.6 -7.61 -0.42 4.78e-13 Monocyte count; CESC cis rs113835537 0.529 rs11227525 chr11:66308065 T/G cg22134325 chr11:66188745 NPAS4 0.39 5.86 0.34 1.37e-8 Airway imaging phenotypes; CESC trans rs61931739 0.500 rs11053269 chr12:34545307 A/G cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.74e-12 Morning vs. evening chronotype; CESC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg23708337 chr7:1209742 NA 0.52 5.14 0.3 5.37e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg07414643 chr4:187882934 NA 0.55 7.6 0.42 4.98e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg06494592 chr3:125709126 NA -0.51 -5.46 -0.32 1.12e-7 Blood pressure (smoking interaction); CESC cis rs1691799 0.899 rs1168318 chr12:66745269 A/G cg16791601 chr12:66731901 HELB 0.75 13.67 0.64 1.49e-32 White blood cell count (basophil); CESC cis rs7917772 0.503 rs7904955 chr10:104367092 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.56 7.33 0.41 2.73e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.55 -7.31 -0.41 3.22e-12 Menarche (age at onset); CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg23131131 chr22:24373011 LOC391322 -0.68 -9.33 -0.5 4.27e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg16680214 chr1:154839983 KCNN3 -0.43 -6.71 -0.38 1.18e-10 Prostate cancer; CESC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg23758822 chr17:41437982 NA -0.86 -12.07 -0.6 4.99e-27 Menopause (age at onset); CESC cis rs6502050 0.605 rs35158616 chr17:80094480 A/G cg23985595 chr17:80112537 CCDC57 -0.43 -6.63 -0.38 1.87e-10 Life satisfaction; CESC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg05313129 chr8:58192883 C8orf71 -0.53 -6.1 -0.35 3.81e-9 Developmental language disorder (linguistic errors); CESC cis rs854765 0.505 rs4924832 chr17:17897739 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.56 7.85 0.43 1.06e-13 Total body bone mineral density; CESC cis rs9303401 0.527 rs2116450 chr17:56745561 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.89 0.62 7.95e-30 Cognitive test performance; CESC cis rs2675662 0.525 rs12264025 chr10:75494450 A/G cg23231163 chr10:75533350 FUT11 -0.35 -5.28 -0.31 2.68e-7 Psoriasis vulgaris;Psoriasis; CESC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg11764359 chr7:65958608 NA 0.79 11.58 0.58 2.22e-25 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15208247 chr1:244857838 PPPDE1 0.46 6.01 0.35 6.12e-9 Fibrinogen levels; CESC cis rs1559088 0.625 rs10411739 chr19:33616327 T/C cg27124370 chr19:33622961 WDR88 0.52 7.36 0.41 2.29e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs56046484 0.871 rs12904958 chr15:85558187 G/C cg08123816 chr15:85640762 PDE8A -0.5 -5.94 -0.34 9.11e-9 Testicular germ cell tumor; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13895650 chr9:84228185 TLE1 -0.36 -6.09 -0.35 3.98e-9 Gambling; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14520079 chr3:106825871 NA 0.44 6.02 0.35 5.67e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4660306 0.961 rs7539253 chr1:45947420 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.86e-13 Homocysteine levels; CESC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg24675658 chr1:53192096 ZYG11B 0.56 6.99 0.39 2.2e-11 Monocyte count; CESC cis rs9354308 0.901 rs2814096 chr6:66566131 G/A cg07460842 chr6:66804631 NA 0.67 7.67 0.43 3.2e-13 Metabolite levels; CESC cis rs12410462 0.681 rs74582965 chr1:227610126 C/T cg04117972 chr1:227635322 NA 0.8 6.95 0.39 2.81e-11 Major depressive disorder; CESC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg26939375 chr7:64535504 NA 0.69 9.76 0.51 2e-19 Calcium levels; CESC cis rs2644899 0.785 rs2604895 chr19:41292263 T/A cg24958765 chr19:41283667 RAB4B -0.56 -6.25 -0.36 1.61e-9 Post bronchodilator FEV1/FVC ratio; CESC trans rs4234798 0.546 rs4689667 chr4:7249188 A/T cg19763168 chr4:84256184 HPSE 0.59 6.88 0.39 4.38e-11 Insulin-like growth factors; CESC cis rs10097731 0.901 rs10464892 chr8:82042991 A/G cg25230327 chr8:82042993 NA 0.57 6.4 0.37 7.03e-10 Serum total protein level; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08054244 chr14:88789549 KCNK10 -0.44 -6.35 -0.36 9.17e-10 Gut microbiota (bacterial taxa); CESC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg07701084 chr6:150067640 NUP43 0.42 5.63 0.33 4.66e-8 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10405333 chr21:28516138 NA -0.53 -6.48 -0.37 4.41e-10 Gut microbiome composition (summer); CESC cis rs7927592 0.763 rs7120876 chr11:68261398 C/G cg16797656 chr11:68205561 LRP5 0.48 7.32 0.41 2.92e-12 Total body bone mineral density; CESC cis rs1879734 0.636 rs12043520 chr1:54184097 G/A cg23596471 chr1:54105337 GLIS1 0.31 5.06 0.3 7.86e-7 Mitral valve prolapse; CESC cis rs2228479 0.850 rs76075456 chr16:89834270 T/C cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6089829 0.888 rs4809468 chr20:61673566 T/C cg23505145 chr19:12996616 KLF1 0.51 6.42 0.37 6.17e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg21548813 chr6:291882 DUSP22 -0.76 -10.58 -0.54 4.63e-22 Menopause (age at onset); CESC cis rs6993244 1 rs6993244 chr8:8863059 C/G cg06636001 chr8:8085503 FLJ10661 0.44 5.75 0.33 2.46e-8 Mean corpuscular hemoglobin; CESC cis rs752010 0.746 rs10749837 chr1:42089471 T/C cg12614395 chr1:42085415 HIVEP3 0.3 5.22 0.31 3.69e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg03806693 chr22:41940476 POLR3H 1.12 15.09 0.68 1.44e-37 Crohn's disease;Inflammatory bowel disease; CESC cis rs2204008 0.777 rs2387813 chr12:38382091 A/C cg13010199 chr12:38710504 ALG10B 0.45 5.88 0.34 1.23e-8 Bladder cancer; CESC cis rs7520050 0.931 rs6698247 chr1:46371486 C/T cg24296786 chr1:45957014 TESK2 0.44 5.55 0.32 7.05e-8 Red blood cell count;Reticulocyte count; CESC cis rs11030122 0.702 rs4910868 chr11:3980224 A/C cg18678763 chr11:4115507 RRM1 -0.49 -6.59 -0.38 2.4e-10 Mean platelet volume;Platelet distribution width; CESC cis rs9814567 1.000 rs7374158 chr3:134270156 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.08 -0.35 4.19e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs72781680 0.848 rs715646 chr2:24010566 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC trans rs11039798 0.920 rs12292685 chr11:48571032 G/T cg15704280 chr7:45808275 SEPT13 0.7 6.69 0.38 1.3100000000000001e-10 Axial length; CESC cis rs9527 0.641 rs10786732 chr10:104762535 T/C cg04362960 chr10:104952993 NT5C2 0.42 5.31 0.31 2.33e-7 Arsenic metabolism; CESC cis rs6032067 0.929 rs6032055 chr20:43833336 C/T cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.57e-7 Blood protein levels; CESC cis rs10751667 0.666 rs4074235 chr11:977511 C/G cg06064525 chr11:970664 AP2A2 -0.47 -9.12 -0.49 1.9e-17 Alzheimer's disease (late onset); CESC cis rs4474465 1.000 rs7950756 chr11:78157309 A/G cg27205649 chr11:78285834 NARS2 -0.42 -5.11 -0.3 6.13e-7 Alzheimer's disease (survival time); CESC cis rs4891159 0.790 rs72975930 chr18:74144645 G/A cg24786174 chr18:74118243 ZNF516 -0.72 -10.87 -0.56 5.42e-23 Longevity; CESC cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg02297831 chr4:17616191 MED28 0.55 6.95 0.39 2.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs7647973 0.626 rs4855845 chr3:49687043 T/C cg21659725 chr3:3221576 CRBN -0.5 -5.99 -0.35 6.66e-9 Menarche (age at onset); CESC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg00999950 chr4:99064541 C4orf37 0.4 5.05 0.3 8.36e-7 Colonoscopy-negative controls vs population controls; CESC cis rs924607 0.900 rs1697950 chr5:616890 G/A cg09021430 chr5:549028 NA 0.38 6.78 0.38 7.99e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7662987 0.517 rs2034696 chr4:100024322 C/G cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.21e-14 Smoking initiation; CESC cis rs1707322 0.963 rs12145287 chr1:46325002 C/G cg05343316 chr1:45956843 TESK2 0.49 5.96 0.34 7.98e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1023500 0.505 rs134888 chr22:42674281 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.39 -5.09 -0.3 6.91e-7 Schizophrenia; CESC cis rs7264396 0.635 rs6058378 chr20:34546658 G/A cg17201900 chr20:34330562 RBM39 0.52 5.44 0.32 1.21e-7 Total cholesterol levels; CESC cis rs6545883 0.862 rs778141 chr2:61682178 A/G cg15711740 chr2:61764176 XPO1 -0.4 -5.24 -0.31 3.24e-7 Tuberculosis; CESC cis rs12586317 0.586 rs2295103 chr14:35515920 C/G cg05294307 chr14:35346193 BAZ1A -0.53 -5.47 -0.32 1.03e-7 Psoriasis; CESC trans rs4843747 0.573 rs7499959 chr16:88110422 C/G cg26811252 chr16:29126840 RRN3P2 0.63 8.83 0.48 1.46e-16 Menopause (age at onset); CESC cis rs9916302 0.904 rs11078897 chr17:37415870 C/T cg15445000 chr17:37608096 MED1 0.41 6.59 0.38 2.43e-10 Glomerular filtration rate (creatinine); CESC cis rs763121 0.819 rs5757126 chr22:38923675 T/C cg06544989 chr22:39130855 UNC84B 0.49 8.04 0.44 2.94e-14 Menopause (age at onset); CESC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg12667521 chr19:29218732 NA 0.47 6.23 0.36 1.78e-9 Methadone dose in opioid dependence; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg22158956 chr4:39529514 UGDH -0.57 -6.69 -0.38 1.33e-10 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.94 0.34 8.93e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6594499 0.872 rs7732974 chr5:110455381 T/C cg04022379 chr5:110408740 TSLP 0.32 5.74 0.33 2.57e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs921968 0.643 rs10187066 chr2:219514759 A/G cg02176678 chr2:219576539 TTLL4 0.41 7.3 0.41 3.26e-12 Mean corpuscular hemoglobin concentration; CESC cis rs684232 0.602 rs331008 chr17:544617 C/T cg12384639 chr17:618140 VPS53 0.41 5.31 0.31 2.36e-7 Prostate cancer; CESC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.31 0.54 3.54e-21 Platelet count; CESC cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4948102 0.690 rs35844144 chr7:56050525 C/T cg09872392 chr7:56161020 PHKG1 -0.44 -6.89 -0.39 3.97e-11 Plasma homocysteine levels (post-methionine load test); CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg19592336 chr6:28129416 ZNF389 0.63 8.37 0.46 3.45e-15 Depression; CESC cis rs9818941 0.784 rs7614747 chr3:157750934 T/C cg08654915 chr3:157813417 NA -0.46 -7.48 -0.42 1.08e-12 Height; CESC trans rs4950322 0.580 rs7515160 chr1:146592296 C/T cg04954894 chr8:38089920 DDHD2 -0.6 -6.62 -0.38 2e-10 Protein quantitative trait loci; CESC cis rs7771547 0.573 rs629297 chr6:36398146 C/T cg04289385 chr6:36355825 ETV7 0.38 5.57 0.32 6.36e-8 Platelet distribution width; CESC cis rs7666738 0.830 rs1426672 chr4:98923984 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg06873352 chr17:61820015 STRADA 0.73 12.89 0.62 7.87e-30 Prudent dietary pattern; CESC cis rs12282928 1.000 rs12288484 chr11:48327476 G/T cg26585981 chr11:48327164 OR4S1 0.39 5.34 0.31 2e-7 Migraine - clinic-based; CESC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg27165867 chr14:105738592 BRF1 -0.53 -6.2 -0.36 2.13e-9 Mean platelet volume;Platelet distribution width; CESC cis rs1008375 0.897 rs67455495 chr4:17665238 A/T cg16339924 chr4:17578868 LAP3 -0.66 -7.59 -0.42 5.58e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs36096196 0.891 rs74046969 chr1:2251348 G/A cg00093522 chr1:2252019 NA 0.44 6.11 0.35 3.63e-9 Coronary artery disease; CESC cis rs2637266 0.678 rs35278870 chr10:78471394 G/A cg18941641 chr10:78392320 NA 0.4 7.38 0.41 2.09e-12 Pulmonary function; CESC cis rs9300255 0.739 rs1980252 chr12:123745178 C/G cg05973401 chr12:123451056 ABCB9 0.5 5.68 0.33 3.53e-8 Neutrophil percentage of white cells; CESC cis rs11098499 0.874 rs6851169 chr4:120117510 T/C cg09307838 chr4:120376055 NA 0.74 9.24 0.49 8.6e-18 Corneal astigmatism; CESC cis rs2251381 0.808 rs7364112 chr21:30548968 C/A cg24692254 chr21:30365293 RNF160 0.77 10.53 0.54 7.06e-22 Selective IgA deficiency; CESC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.61 8.14 0.45 1.53e-14 Menopause (age at onset); CESC cis rs1387259 0.839 rs7486941 chr12:48578631 C/G cg04545296 chr12:48745243 ZNF641 -0.33 -5.87 -0.34 1.29e-8 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs7247513 0.866 rs2861405 chr19:12722332 A/C cg01871581 chr19:12707946 ZNF490 -0.85 -13.3 -0.63 2.89e-31 Bipolar disorder; CESC cis rs1018836 0.544 rs10112371 chr8:91457626 C/T cg16814680 chr8:91681699 NA 0.46 6.21 0.36 1.98e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1707322 0.789 rs10789473 chr1:46248131 C/T cg06784218 chr1:46089804 CCDC17 0.36 6.14 0.35 3e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7503807 0.664 rs9902390 chr17:78574387 G/A cg09596252 chr17:78655493 RPTOR 0.39 5.23 0.31 3.41e-7 Obesity; CESC cis rs208520 0.545 rs10944874 chr6:66752080 C/T cg07460842 chr6:66804631 NA -1.01 -20.61 -0.78 5.53e-57 Exhaled nitric oxide output; CESC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg00166722 chr3:10149974 C3orf24 0.53 6.6 0.38 2.26e-10 Alzheimer's disease; CESC cis rs1005277 0.522 rs1208684 chr10:38093936 G/A cg25427524 chr10:38739819 LOC399744 -0.64 -9.72 -0.51 2.69e-19 Extrinsic epigenetic age acceleration; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23224405 chr12:12715060 DUSP16 0.44 6.08 0.35 4.1e-9 Intelligence (multi-trait analysis); CESC cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg23221052 chr5:179740743 GFPT2 -0.53 -7.15 -0.4 8.68e-12 Height; CESC cis rs11792861 0.890 rs3087979 chr9:111781779 T/C cg05043794 chr9:111880884 C9orf5 -0.41 -6.82 -0.39 6.13e-11 Menarche (age at onset); CESC cis rs853679 0.882 rs4713140 chr6:28097193 C/T cg26335602 chr6:28129616 ZNF389 0.54 5.45 0.32 1.14e-7 Depression; CESC cis rs4243830 0.850 rs932112 chr1:6591937 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.98 -10.08 -0.53 1.95e-20 Body mass index; CESC cis rs17122021 0.625 rs3759001 chr11:118135745 A/G cg26487031 chr11:118134801 MPZL2 -0.26 -5.12 -0.3 5.95e-7 Pain; CESC cis rs4253772 0.591 rs9615934 chr22:46682310 C/G cg18190219 chr22:46762943 CELSR1 -0.63 -6.51 -0.37 3.65e-10 LDL cholesterol;Cholesterol, total; CESC cis rs11625487 0.515 rs12434419 chr14:77855617 G/A cg20045696 chr14:77926864 AHSA1 -0.68 -9.12 -0.49 1.94e-17 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs2635047 0.811 rs17785419 chr18:44765469 A/G cg24371990 chr18:44770781 NA -0.44 -7.33 -0.41 2.73e-12 Educational attainment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27062573 chr22:39549099 CBX7 0.61 7.05 0.4 1.51e-11 Gut microbiome composition (summer); CESC cis rs1707322 0.721 rs4660883 chr1:46236098 C/T cg05343316 chr1:45956843 TESK2 0.48 5.84 0.34 1.5e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9611565 0.765 rs132906 chr22:41799767 G/C cg03806693 chr22:41940476 POLR3H 0.7 8.58 0.47 8.15e-16 Vitiligo; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22833807 chr22:36925177 EIF3D 0.48 6.2 0.36 2.14e-9 Gut microbiota (bacterial taxa); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15012766 chr1:41832369 NA 0.43 6.21 0.36 2.01e-9 Gut microbiota (bacterial taxa); CESC cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg18512352 chr11:47633146 NA -0.51 -7.43 -0.42 1.46e-12 Subjective well-being; CESC cis rs7662987 1.000 rs13119035 chr4:99999130 A/G cg13256891 chr4:100009986 ADH5 -0.84 -6.09 -0.35 3.92e-9 Smoking initiation; CESC cis rs501120 0.929 rs2576354 chr10:44750393 G/A cg09554077 chr10:44749378 NA 0.48 5.94 0.34 8.9e-9 Coronary artery disease;Coronary heart disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03277652 chr8:142011117 PTK2 0.56 6.33 0.36 1.06e-9 Gut microbiome composition (summer); CESC trans rs9325144 0.541 rs7303395 chr12:38664124 C/T cg23762105 chr12:34175262 ALG10 0.48 6.31 0.36 1.15e-9 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.791 rs7657399 chr4:98851861 T/C cg17366294 chr4:99064904 C4orf37 0.54 7.48 0.42 1.1e-12 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.591 rs75804221 chr7:12364319 C/T cg20607287 chr7:12443886 VWDE -0.62 -6.71 -0.38 1.2e-10 Coronary artery disease; CESC cis rs7923609 0.902 rs7897379 chr10:65301725 T/C cg01631684 chr10:65280961 REEP3 -0.41 -5.12 -0.3 5.95e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs10129255 1.000 rs10134517 chr14:107173745 T/C cg07958169 chr14:107095056 NA -0.39 -5.24 -0.31 3.21e-7 Kawasaki disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11660684 chr10:126490277 FAM175B 0.53 6.05 0.35 5.02e-9 Gut microbiome composition (summer); CESC trans rs7824557 0.527 rs4634600 chr8:11239017 T/A cg15556689 chr8:8085844 FLJ10661 -0.48 -6.09 -0.35 3.85e-9 Retinal vascular caliber; CESC cis rs12586317 0.547 rs116499019 chr14:35441931 T/C cg16230307 chr14:35515116 FAM177A1 0.96 10.66 0.55 2.55e-22 Psoriasis; CESC cis rs193541 0.556 rs30024 chr5:122285160 A/G cg19412675 chr5:122181750 SNX24 0.46 5.45 0.32 1.16e-7 Glucose homeostasis traits; CESC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg09359103 chr1:154839909 KCNN3 -0.65 -12.33 -0.6 6.58e-28 Prostate cancer; CESC cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg05347473 chr6:146136440 FBXO30 0.56 7.19 0.4 6.72e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs763014 0.833 rs916415 chr16:632115 G/A cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05617300 chr19:59093449 MGC2752 -0.57 -6.21 -0.36 2.06e-9 Gut microbiome composition (summer); CESC cis rs4595586 0.679 rs7955725 chr12:39322903 C/T cg26384229 chr12:38710491 ALG10B 0.43 6.31 0.36 1.2e-9 Morning vs. evening chronotype; CESC cis rs8077889 1.000 rs17675122 chr17:41886190 A/G cg26893861 chr17:41843967 DUSP3 0.84 9.77 0.51 1.89e-19 Triglycerides; CESC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg19391498 chr2:38892846 GALM -0.53 -6.96 -0.39 2.66e-11 5-HTT brain serotonin transporter levels; CESC cis rs7631605 0.905 rs11708049 chr3:37261396 T/C cg22985146 chr3:37219077 LRRFIP2 -0.35 -5.44 -0.32 1.18e-7 Cerebrospinal P-tau181p levels; CESC cis rs8005677 0.828 rs4981450 chr14:23389304 A/G cg01529538 chr14:23388837 RBM23 0.45 6.03 0.35 5.55e-9 Cognitive ability (multi-trait analysis); CESC cis rs2635047 0.542 rs1512236 chr18:44768493 C/T cg24371990 chr18:44770781 NA -0.36 -5.92 -0.34 9.71e-9 Educational attainment; CESC cis rs6570726 0.935 rs442254 chr6:145849118 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.96e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg05025164 chr4:1340916 KIAA1530 0.43 5.79 0.34 2e-8 Longevity; CESC cis rs68092024 0.731 rs792841 chr3:99471308 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -6.75 -0.38 9.41e-11 Cleft lip with or without cleft palate; CESC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg21784768 chr11:537496 LRRC56 -0.54 -5.08 -0.3 7.13e-7 Body mass index; CESC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg04772025 chr11:68637568 NA 0.55 6.29 0.36 1.3e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8017423 0.605 rs8181930 chr14:90811289 A/G cg14092571 chr14:90743983 NA 0.53 8.22 0.45 9.31e-15 Mortality in heart failure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22897130 chr10:89419623 PAPSS2 -0.43 -6.03 -0.35 5.37e-9 Fibrinogen levels; CESC cis rs6570726 0.935 rs397418 chr6:145842362 C/T cg05347473 chr6:146136440 FBXO30 0.48 6.58 0.37 2.54e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4835473 0.932 rs6827971 chr4:144743279 G/C cg25736465 chr4:144833511 NA -0.32 -5.09 -0.3 6.9e-7 Immature fraction of reticulocytes; CESC cis rs17095355 1.000 rs2419313 chr10:111750851 G/A cg00817464 chr10:111662876 XPNPEP1 -0.45 -5.04 -0.3 8.75e-7 Biliary atresia; CESC cis rs7520050 0.807 rs6656279 chr1:46124088 C/G cg06784218 chr1:46089804 CCDC17 0.33 5.95 0.34 8.25e-9 Red blood cell count;Reticulocyte count; CESC cis rs3008870 1.000 rs3008854 chr1:67385951 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.06 14.98 0.68 3.54e-37 Lymphocyte percentage of white cells; CESC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg19717773 chr7:2847554 GNA12 -0.56 -8.06 -0.44 2.65e-14 Height; CESC cis rs10751667 0.666 rs7394427 chr11:970405 G/A cg06064525 chr11:970664 AP2A2 -0.47 -9.13 -0.49 1.87e-17 Alzheimer's disease (late onset); CESC cis rs9309473 0.500 rs11126402 chr2:73776582 G/C cg20560298 chr2:73613845 ALMS1 -0.49 -7.07 -0.4 1.37e-11 Metabolite levels; CESC cis rs11958404 0.860 rs6868839 chr5:157442196 T/G cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -6.71 -0.38 1.2e-10 Bipolar disorder; CESC cis rs6963495 0.818 rs73192149 chr7:105210910 A/G cg13798780 chr7:105162888 PUS7 0.77 7.63 0.42 4.27e-13 Bipolar disorder (body mass index interaction); CESC cis rs10791097 0.629 rs11222361 chr11:130731424 T/G cg09137382 chr11:130731461 NA 0.39 5.84 0.34 1.51e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg18180107 chr4:99064573 C4orf37 0.42 5.4 0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg15465092 chr8:128747754 MYC -0.49 -6.09 -0.35 4.01e-9 Psoriatic arthritis; CESC cis rs11122272 0.735 rs2474630 chr1:231535335 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs722599 0.961 rs2359239 chr14:75326771 C/T cg08847533 chr14:75593920 NEK9 -0.45 -5.68 -0.33 3.53e-8 IgG glycosylation; CESC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg19468946 chr17:37922297 IKZF3 0.39 5.08 0.3 7e-7 Glomerular filtration rate (creatinine); CESC cis rs4523957 0.620 rs8070272 chr17:2063117 A/G cg16513277 chr17:2031491 SMG6 -0.69 -9.59 -0.51 6.97e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6785206 1.000 rs6785206 chr3:128412024 A/G cg16766828 chr3:128327626 NA -0.53 -5.05 -0.3 8.16e-7 Lymphocyte percentage of white cells; CESC cis rs9581857 0.547 rs9319374 chr13:28047587 A/C cg22138327 chr13:27999177 GTF3A 0.61 5.03 0.3 9.09e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18827097 chr2:3522506 ADI1 0.5 6.72 0.38 1.11e-10 Systemic lupus erythematosus; CESC cis rs1348850 0.567 rs12994392 chr2:178536640 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.16 0.4 7.91e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg11764359 chr7:65958608 NA -0.95 -15.7 -0.69 1.03e-39 Aortic root size; CESC cis rs1707322 0.721 rs11211181 chr1:46236800 C/T cg03146154 chr1:46216737 IPP 0.76 10.84 0.55 6.51e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7944584 0.502 rs10769256 chr11:47378396 C/T cg05585544 chr11:47624801 NA 0.36 5.25 0.31 3.19e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs2011503 0.943 rs2965195 chr19:19463032 A/G cg11584989 chr19:19387371 SF4 -0.63 -7.48 -0.42 1.1e-12 Bipolar disorder; CESC trans rs12542260 0.871 rs7834203 chr8:125482896 A/G cg09438698 chr12:133365205 GOLGA3 -0.47 -6.05 -0.35 4.83e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg13114125 chr14:105738426 BRF1 -0.82 -10.21 -0.53 7.24e-21 Mean platelet volume;Platelet distribution width; CESC cis rs7246865 0.510 rs3816550 chr19:17173487 A/G cg16202187 chr19:17186497 HAUS8;MYO9B 0.48 6.28 0.36 1.38e-9 Reticulocyte fraction of red cells; CESC cis rs765787 0.530 rs12904265 chr15:45526713 C/T cg24006582 chr15:45444508 DUOX1 0.58 6.97 0.39 2.5e-11 Uric acid levels; CESC cis rs2046867 0.862 rs2322611 chr3:72830087 T/G cg25664220 chr3:72788482 NA -0.46 -6.73 -0.38 1.06e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs11602339 1 rs11602339 chr11:47761471 C/T cg05585544 chr11:47624801 NA -0.52 -8.05 -0.44 2.78e-14 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15472574 chr1:43148457 YBX1 0.55 6.03 0.35 5.52e-9 Gut microbiome composition (summer); CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg05906620 chr10:69523794 NA 0.52 6.66 0.38 1.59e-10 Attention deficit hyperactivity disorder; CESC cis rs12681288 0.645 rs2600509 chr8:989022 C/G cg15309053 chr8:964076 NA -0.38 -6.47 -0.37 4.6e-10 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25062357 chr20:2821267 VPS16;FAM113A -0.47 -6.64 -0.38 1.73e-10 Fibrinogen levels; CESC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg00166722 chr3:10149974 C3orf24 0.46 5.88 0.34 1.21e-8 Alzheimer's disease; CESC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.95 0.34 8.43e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17738503 chr17:49244158 NME2;NME1-NME2 0.54 6.5 0.37 3.98e-10 Gut microbiome composition (summer); CESC cis rs1538970 0.816 rs11211123 chr1:45957609 G/A cg06784218 chr1:46089804 CCDC17 0.37 5.9 0.34 1.11e-8 Platelet count; CESC cis rs9291683 0.609 rs34709913 chr4:10028955 T/C cg11266682 chr4:10021025 SLC2A9 0.71 14.13 0.66 3.7e-34 Bone mineral density; CESC cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.45 -7.13 -0.4 9.76e-12 Hemoglobin concentration; CESC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg11764359 chr7:65958608 NA -0.8 -8.96 -0.48 5.83e-17 Aortic root size; CESC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg19717773 chr7:2847554 GNA12 -0.56 -8.14 -0.45 1.52e-14 Height; CESC cis rs6424115 1.000 rs12031592 chr1:24127864 A/C cg10978503 chr1:24200527 CNR2 0.27 5.46 0.32 1.08e-7 Immature fraction of reticulocytes; CESC cis rs10911232 0.507 rs10911231 chr1:183051745 T/A ch.1.3577855R chr1:183094577 LAMC1 0.85 13.7 0.64 1.21e-32 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10236503 chr4:153456147 FBXW7 0.59 6.51 0.37 3.79e-10 Gut microbiome composition (summer); CESC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg05863683 chr7:1912471 MAD1L1 0.43 6.35 0.36 9.24e-10 Bipolar disorder and schizophrenia; CESC cis rs1153858 1.000 rs4774578 chr15:45646051 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.45e-9 Homoarginine levels; CESC cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.34 0.31 2.01e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.33 -0.31 2.07e-7 Lung cancer; CESC cis rs10504073 0.584 rs56068225 chr8:49923988 A/G cg00325661 chr8:49890786 NA 0.55 8.31 0.45 5.1e-15 Blood metabolite ratios; CESC cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg24308560 chr3:49941425 MST1R -0.6 -8.81 -0.48 1.7e-16 Intelligence (multi-trait analysis); CESC cis rs4975709 0.569 rs2353583 chr5:1858834 G/C cg14773178 chr5:1868261 NA 0.32 5.53 0.32 7.49e-8 Cardiovascular disease risk factors; CESC cis rs8078723 0.714 rs3785550 chr17:38149727 C/T cg17467752 chr17:38218738 THRA -0.56 -8.52 -0.46 1.25e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg06766960 chr11:133703094 NA -0.39 -5.46 -0.32 1.08e-7 Childhood ear infection; CESC cis rs3762637 1.000 rs7615673 chr3:122125544 G/C cg24169773 chr3:122142474 KPNA1 -0.49 -5.69 -0.33 3.41e-8 LDL cholesterol levels; CESC cis rs9291683 0.530 rs882223 chr4:9981625 A/C cg00071950 chr4:10020882 SLC2A9 0.78 14.43 0.66 3.07e-35 Bone mineral density; CESC cis rs131777 0.526 rs86337 chr22:51020668 C/A cg25309564 chr22:51001381 C22orf41 0.44 5.47 0.32 1.05e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs4253772 0.550 rs6007761 chr22:46670394 C/T cg10231785 chr22:46692440 CN5H6.4;GTSE1 -0.51 -5.61 -0.33 5.19e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7605378 1.000 rs2577852 chr2:200687248 C/T cg23649088 chr2:200775458 C2orf69 0.52 6.78 0.38 7.69e-11 Osteoporosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26145502 chr1:8939074 ENO1 0.58 6.75 0.38 9.32e-11 Gut microbiome composition (summer); CESC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.79 -0.55 9.74e-23 Alzheimer's disease; CESC cis rs11711311 1.000 rs9851731 chr3:113502651 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.56 -7.4 -0.41 1.77e-12 IgG glycosylation; CESC cis rs2439831 0.850 rs12442129 chr15:44055856 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.71 8.12 0.45 1.78e-14 Lung cancer in ever smokers; CESC cis rs9291683 0.517 rs11736479 chr4:10017387 G/C cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.73e-37 Bone mineral density; CESC trans rs1814175 0.781 rs1851872 chr11:50009770 A/G cg03929089 chr4:120376271 NA -0.93 -15.84 -0.7 3.36e-40 Height; CESC cis rs6831352 0.734 rs1453872 chr4:100022482 G/A cg12011299 chr4:100065546 ADH4 0.57 6.88 0.39 4.28e-11 Alcohol dependence; CESC cis rs8067545 0.532 rs17759609 chr17:19992514 C/G cg12073167 chr17:19770448 ULK2 -0.43 -5.22 -0.31 3.65e-7 Schizophrenia; CESC cis rs72627123 0.749 rs58199545 chr14:74452495 G/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.79 5.35 0.31 1.9e-7 Morning vs. evening chronotype; CESC cis rs3008870 0.920 rs3008865 chr1:67402838 T/C cg02640540 chr1:67518911 SLC35D1 0.52 5.66 0.33 3.9e-8 Lymphocyte percentage of white cells; CESC cis rs6540559 0.546 rs7551944 chr1:210029430 G/C cg22029157 chr1:209979665 IRF6 0.73 7.21 0.41 5.76e-12 Cleft lip with or without cleft palate; CESC cis rs425277 0.917 rs78609670 chr1:2045886 G/T cg24578937 chr1:2090814 PRKCZ 0.55 9.07 0.49 2.75e-17 Height; CESC cis rs7264396 0.616 rs6060744 chr20:34581555 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -7.91 -0.44 6.96e-14 Total cholesterol levels; CESC cis rs4523957 0.651 rs4790315 chr17:2070529 T/C cg16513277 chr17:2031491 SMG6 -0.72 -10.21 -0.53 7.63e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg24250549 chr1:154909240 PMVK 0.72 10.46 0.54 1.18e-21 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03700121 chr11:60610004 CCDC86 0.55 6.46 0.37 5.1e-10 Gut microbiome composition (summer); CESC cis rs8078723 1.000 rs4794823 chr17:38166265 A/T cg17467752 chr17:38218738 THRA 0.69 10.54 0.54 6.17e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs11997175 0.545 rs67960786 chr8:33668770 G/A ch.8.33884649F chr8:33765107 NA 0.52 6.44 0.37 5.64e-10 Body mass index; CESC cis rs2880765 0.835 rs4514633 chr15:86041017 T/G cg10818794 chr15:86012489 AKAP13 -0.35 -5.39 -0.31 1.52e-7 Coronary artery disease; CESC cis rs1670533 1.000 rs62294756 chr4:1097676 G/A cg27284194 chr4:1044797 NA -0.47 -5.98 -0.34 7.28e-9 Recombination rate (females); CESC cis rs2463822 1.000 rs1406384 chr11:62083530 A/G cg06239285 chr11:62104954 ASRGL1 -0.92 -9.18 -0.49 1.31e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs3008870 0.701 rs2815367 chr1:67500762 G/A cg02640540 chr1:67518911 SLC35D1 0.44 5.36 0.31 1.84e-7 Lymphocyte percentage of white cells; CESC cis rs57602752 1.000 rs11813877 chr10:120640509 C/G cg26403580 chr10:120936730 PRDX3 0.5 5.04 0.3 8.48e-7 Cannabis dependence; CESC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg06453172 chr10:134556979 INPP5A -0.41 -5.31 -0.31 2.29e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2295499 0.754 rs73207343 chr4:2628854 T/A cg27239842 chr4:2403781 ZFYVE28 -0.32 -5.24 -0.31 3.26e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs15676 0.783 rs4837316 chr9:131577450 A/G cg00228799 chr9:131580591 ENDOG 0.55 6.91 0.39 3.53e-11 Blood metabolite levels; CESC cis rs854765 0.547 rs12150369 chr17:17911014 G/A cg09796270 chr17:17721594 SREBF1 0.39 5.47 0.32 1.06e-7 Total body bone mineral density; CESC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs7762018 1.000 rs4716380 chr6:170090399 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.53 5.53 0.32 7.7e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs61931739 0.500 rs12367292 chr12:33998075 T/C cg26384229 chr12:38710491 ALG10B 0.58 8.14 0.45 1.51e-14 Morning vs. evening chronotype; CESC cis rs12142240 0.667 rs66990604 chr1:46822073 G/A cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs2180341 0.855 rs4308584 chr6:127714874 A/G cg27446573 chr6:127587934 RNF146 0.81 11.43 0.57 7.46e-25 Breast cancer; CESC cis rs3741404 0.757 rs2282492 chr11:63918589 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 11.99 0.59 9.14e-27 Platelet count; CESC cis rs10256972 0.527 rs28671326 chr7:1174973 G/A cg22907277 chr7:1156413 C7orf50 0.42 6.07 0.35 4.52e-9 Longevity;Endometriosis; CESC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.21 -0.41 5.78e-12 Developmental language disorder (linguistic errors); CESC trans rs10751667 1.000 rs6597972 chr11:928402 C/T cg00159523 chr10:114713187 TCF7L2 -0.42 -6.28 -0.36 1.39e-9 Alzheimer's disease (late onset); CESC cis rs12347191 0.500 rs1465965 chr9:100620326 C/T cg13688889 chr9:100608707 NA -0.91 -13.42 -0.64 1.07e-31 Orofacial clefts; CESC cis rs7143963 0.636 rs2180393 chr14:103293845 T/C cg24154132 chr14:103367632 TRAF3 0.34 6.31 0.36 1.16e-9 Body mass index; CESC cis rs11190604 1.000 rs7070776 chr10:102264672 A/G cg07080220 chr10:102295463 HIF1AN 0.61 5.78 0.33 2.06e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15186648 chr13:103452789 BIVM;KDELC1 0.52 6.07 0.35 4.37e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.66 0.61 4.8e-29 Colonoscopy-negative controls vs population controls; CESC cis rs4704187 0.687 rs9654429 chr5:74466925 C/G cg03227963 chr5:74354835 NA 0.28 5.21 0.3 3.77e-7 Response to amphetamines; CESC cis rs8067354 0.645 rs2271304 chr17:57814641 A/G cg13753209 chr17:57696993 CLTC 0.56 6.1 0.35 3.83e-9 Hemoglobin concentration; CESC cis rs4919044 1.000 rs17108043 chr10:94770697 A/G cg16508068 chr10:94451736 HHEX 0.51 5.36 0.31 1.77e-7 Coronary artery disease; CESC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg06221963 chr1:154839813 KCNN3 -0.67 -11.28 -0.57 2.31e-24 Prostate cancer; CESC cis rs45535039 0.506 rs2511856 chr11:119144148 A/C cg16724696 chr11:118992527 HINFP -0.41 -5.6 -0.33 5.25e-8 Plateletcrit; CESC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.6e-24 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10523380 chr6:7141602 RREB1 0.55 6.53 0.37 3.34e-10 Gut microbiome composition (summer); CESC cis rs2952156 0.883 rs907088 chr17:37833567 G/C cg20243544 chr17:37824526 PNMT 0.62 8.21 0.45 9.57e-15 Asthma; CESC cis rs6541297 0.703 rs628035 chr1:230324145 G/T cg20703242 chr1:230279135 GALNT2 -0.4 -5.26 -0.31 2.96e-7 Coronary artery disease; CESC cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg13877915 chr19:58951672 ZNF132 0.39 5.79 0.34 1.94e-8 Uric acid clearance; CESC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.27 0.6 1.07e-27 Alzheimer's disease; CESC cis rs2425143 1.000 rs1890470 chr20:34357008 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.72 6.82 0.39 6.12e-11 Blood protein levels; CESC cis rs7917772 0.636 rs2250580 chr10:104505687 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 5.76 0.33 2.36e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs372883 0.597 rs2018956 chr21:30736622 C/A cg24692254 chr21:30365293 RNF160 0.45 5.69 0.33 3.27e-8 Pancreatic cancer; CESC trans rs10242455 0.571 rs73713595 chr7:99326659 G/A cg09045935 chr12:6379348 NA 0.75 6.29 0.36 1.3e-9 Blood metabolite levels; CESC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg11764359 chr7:65958608 NA 0.82 10.05 0.53 2.44e-20 Aortic root size; CESC cis rs17376456 0.877 rs10070390 chr5:93452345 G/A cg21475434 chr5:93447410 FAM172A 0.82 7.56 0.42 6.81e-13 Diabetic retinopathy; CESC cis rs2191566 0.576 rs381983 chr19:44494215 C/T cg20607764 chr19:44506953 ZNF230 -0.44 -5.53 -0.32 7.62e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.91 0.48 8.46e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs7949030 0.588 rs2428548 chr11:62311462 A/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.4 -0.31 1.52e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.23e-9 Extrinsic epigenetic age acceleration; CESC cis rs2404602 0.536 rs7163946 chr15:76766049 C/G cg26408565 chr15:76604113 ETFA -0.43 -6.43 -0.37 5.86e-10 Blood metabolite levels; CESC cis rs854765 0.522 rs63721860 chr17:17829576 T/C cg09796270 chr17:17721594 SREBF1 0.4 5.6 0.33 5.43e-8 Total body bone mineral density; CESC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg13628971 chr7:2884303 GNA12 0.61 8.03 0.44 3.3e-14 Height; CESC cis rs6088580 0.634 rs6142157 chr20:32984172 C/G cg06115741 chr20:33292138 TP53INP2 -0.47 -6.08 -0.35 4.22e-9 Glomerular filtration rate (creatinine); CESC cis rs6459788 0.527 rs6980250 chr7:157228710 C/T cg03453431 chr7:157225567 NA -0.42 -7.35 -0.41 2.48e-12 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs7000551 0.715 rs1879793 chr8:22313986 G/A cg12081754 chr8:22256438 SLC39A14 0.41 5.36 0.31 1.78e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs34638657 0.702 rs35865749 chr16:82199677 T/C cg09439754 chr16:82129088 HSD17B2 -0.38 -6.63 -0.38 1.92e-10 Lung adenocarcinoma; CESC cis rs10883723 0.810 rs2296586 chr10:104245575 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 8.47 0.46 1.71e-15 Allergic disease (asthma, hay fever or eczema); CESC cis rs7216064 0.817 rs28609796 chr17:65855104 T/A cg07042672 chr17:66097459 LOC651250 -0.54 -5.62 -0.33 4.74e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs79387448 0.745 rs74560841 chr2:103149210 G/A cg09003973 chr2:102972529 NA 0.7 5.44 0.32 1.2e-7 Gut microbiota (bacterial taxa); CESC cis rs1048238 0.506 rs848210 chr1:16259813 A/G cg21385522 chr1:16154831 NA -0.43 -5.46 -0.32 1.1e-7 Systolic blood pressure; CESC cis rs11722228 0.522 rs77691548 chr4:10136115 T/G cg14348967 chr4:10160060 NA -0.42 -5.58 -0.32 5.91e-8 Gout;Urate levels;Serum uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11354908 chr19:18255899 MAST3 -0.67 -7.45 -0.42 1.29e-12 Gut microbiome composition (summer); CESC cis rs6088580 0.634 rs1205345 chr20:32914699 A/G cg08999081 chr20:33150536 PIGU -0.65 -11.3 -0.57 2.02e-24 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03586379 chr3:140660603 SLC25A36 0.56 6.17 0.35 2.57e-9 Gut microbiome composition (summer); CESC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg01988459 chr11:68622903 NA -0.45 -6.3 -0.36 1.22e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs79976124 0.797 rs77895756 chr6:66626782 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.74 8.48 0.46 1.58e-15 Type 2 diabetes; CESC cis rs10088262 0.527 rs3911939 chr8:124793744 T/G cg02993010 chr8:124780839 FAM91A1 -0.68 -8.21 -0.45 1.01e-14 Pancreatic cancer; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg20249169 chr2:64881356 SERTAD2 -0.45 -6.6 -0.38 2.27e-10 Vertical cup-disc ratio; CESC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.93 0.44 6.13e-14 Electroencephalogram traits; CESC cis rs55728055 0.661 rs9680589 chr22:31853484 G/A cg01338084 chr22:32026380 PISD 1.13 6.83 0.39 5.9e-11 Age-related hearing impairment; CESC cis rs7680126 0.633 rs4698014 chr4:10286301 C/T cg00071950 chr4:10020882 SLC2A9 -0.46 -5.09 -0.3 6.89e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs317689 0.819 rs317660 chr12:69686203 G/A cg14784868 chr12:69753453 YEATS4 0.5 5.37 0.31 1.69e-7 Response to diuretic therapy; CESC cis rs6430585 0.527 rs59413285 chr2:136444185 G/T cg07169764 chr2:136633963 MCM6 1.09 12.56 0.61 1.07e-28 Corneal structure; CESC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg05255149 chr17:80675120 FN3KRP 0.45 5.04 0.3 8.76e-7 Glycated hemoglobin levels; CESC cis rs76878669 0.561 rs11227465 chr11:66115879 T/A cg18002602 chr11:66138449 SLC29A2 -0.46 -7.29 -0.41 3.64e-12 Educational attainment (years of education); CESC cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg05340658 chr4:99064831 C4orf37 0.84 12.81 0.62 1.45e-29 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 0.933 rs3096297 chr16:89453155 T/G cg02187348 chr16:89574699 SPG7 0.57 7.5 0.42 9.65e-13 Multiple myeloma (IgH translocation); CESC cis rs1665050 0.534 rs8028502 chr15:59235876 C/G cg05156742 chr15:59063176 FAM63B 0.5 6.42 0.37 6.18e-10 Atopic dermatitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09254969 chr5:141303622 KIAA0141 -0.46 -6.14 -0.35 3.03e-9 Fibrinogen levels; CESC cis rs933688 0.877 rs1477349 chr5:90707773 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 12.45 0.61 2.47e-28 Smoking behavior; CESC cis rs2074585 0.583 rs28406958 chr15:91069364 C/A cg22089800 chr15:90895588 ZNF774 -0.46 -5.42 -0.32 1.33e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg22920501 chr2:26401640 FAM59B -0.67 -7.97 -0.44 4.81e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10593459 chr1:44447478 B4GALT2 -0.53 -6.36 -0.36 8.68e-10 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21679509 chr7:28219613 JAZF1 -0.44 -6.19 -0.36 2.32e-9 Ulcerative colitis; CESC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.29 0.41 3.54e-12 Height; CESC cis rs11203032 0.831 rs7477966 chr10:90924258 A/G cg16672925 chr10:90967113 CH25H 0.74 6.99 0.39 2.26e-11 Heart failure; CESC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg04234412 chr22:24373322 LOC391322 -0.52 -7.48 -0.42 1.08e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9457247 0.967 rs1794694 chr6:167404751 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.88 0.34 1.26e-8 Crohn's disease; CESC cis rs3781913 0.874 rs11235559 chr11:72374037 C/T cg04827223 chr11:72435913 ARAP1 0.31 5.05 0.3 8.32e-7 Rheumatoid arthritis; CESC cis rs6893300 0.883 rs1469021 chr5:179214251 C/T cg14593053 chr5:179126677 CANX -0.51 -5.57 -0.32 6.16e-8 Resting heart rate; CESC cis rs9303401 1.000 rs6503882 chr17:56915761 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.73 9.4 0.5 2.7e-18 Cognitive test performance; CESC cis rs6460942 1.000 rs117657017 chr7:12318891 T/C cg10578991 chr7:12443926 VWDE -0.61 -6.41 -0.37 6.66e-10 Coronary artery disease; CESC cis rs2180341 0.883 rs7760748 chr6:127690062 C/T cg24812749 chr6:127587940 RNF146 1.05 15.12 0.68 1.2e-37 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13576294 chr9:131124572 NA -0.62 -7.43 -0.42 1.48e-12 Gut microbiome composition (summer); CESC cis rs910316 1.000 rs175449 chr14:75590846 A/T cg11812906 chr14:75593930 NEK9 -0.87 -14.97 -0.68 3.76e-37 Height; CESC cis rs1008375 0.931 rs979823 chr4:17700176 G/A cg02297831 chr4:17616191 MED28 0.48 5.78 0.33 2.07e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg11764359 chr7:65958608 NA 0.69 9.11 0.49 2.05e-17 Aortic root size; CESC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg13175981 chr1:150552382 MCL1 0.62 9.15 0.49 1.59e-17 Tonsillectomy; CESC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg04267008 chr7:1944627 MAD1L1 -0.6 -7.44 -0.42 1.37e-12 Bipolar disorder and schizophrenia; CESC cis rs10189230 0.967 rs7573758 chr2:222357326 G/T cg14652038 chr2:222343519 EPHA4 0.33 6.85 0.39 5.06e-11 Urate levels in lean individuals; CESC cis rs1580019 0.537 rs7804609 chr7:32558094 A/C cg06627557 chr7:32535165 LSM5;AVL9 1.06 19.18 0.76 5.16e-52 Cognitive ability; CESC cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg11764359 chr7:65958608 NA 0.81 9.43 0.5 2.14e-18 Aortic root size; CESC trans rs10411161 0.702 rs11878583 chr19:52388546 C/T cg22319618 chr22:45562946 NUP50 0.77 7.71 0.43 2.51e-13 Breast cancer; CESC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg24531977 chr5:56204891 C5orf35 -0.88 -11.14 -0.56 6.81e-24 Initial pursuit acceleration; CESC cis rs9913156 0.793 rs8074545 chr17:4567337 C/G cg19197139 chr17:4613644 ARRB2 -0.92 -10.59 -0.55 4.42e-22 Lymphocyte counts; CESC cis rs9513593 1.000 rs2296044 chr13:100038825 T/C cg21788972 chr13:99853209 UBAC2 0.64 7.56 0.42 6.41e-13 Psoriasis; CESC cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg03433033 chr1:76189801 ACADM 0.71 9.78 0.52 1.68e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4253772 0.575 rs74879643 chr22:46660014 T/C cg10541313 chr22:46663664 TTC38 0.7 5.24 0.31 3.34e-7 LDL cholesterol;Cholesterol, total; CESC cis rs1595825 0.891 rs76450397 chr2:198786112 T/C cg10820045 chr2:198174542 NA 0.41 5.06 0.3 7.8e-7 Ulcerative colitis; CESC cis rs644799 1.000 rs509720 chr11:95562771 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.57e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs12681288 0.676 rs34282191 chr8:991290 G/A cg04851639 chr8:1020857 NA -0.32 -6.71 -0.38 1.2e-10 Schizophrenia; CESC cis rs7296418 0.599 rs2277343 chr12:123794450 A/T cg00376283 chr12:123451042 ABCB9 0.57 7.71 0.43 2.59e-13 Platelet count; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05899741 chr4:43901084 NA -0.38 -6.0 -0.35 6.55e-9 Asthma; CESC cis rs113835537 0.559 rs57045447 chr11:66339683 A/G cg22134325 chr11:66188745 NPAS4 0.37 5.56 0.32 6.61e-8 Airway imaging phenotypes; CESC cis rs910316 1.000 rs28626045 chr14:75589195 G/C cg08847533 chr14:75593920 NEK9 1.01 19.53 0.77 2.99e-53 Height; CESC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg00166722 chr3:10149974 C3orf24 0.48 5.97 0.34 7.76e-9 Alzheimer's disease; CESC cis rs11690935 0.788 rs10201053 chr2:172889558 A/G cg13550731 chr2:172543902 DYNC1I2 -0.67 -9.0 -0.48 4.41e-17 Schizophrenia; CESC cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 8.7 0.47 3.51e-16 Personality dimensions; CESC cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg05340658 chr4:99064831 C4orf37 0.82 13.05 0.63 2.08e-30 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.26 -0.36 1.52e-9 Total body bone mineral density; CESC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg22244940 chr12:132335942 MMP17 0.4 5.44 0.32 1.2e-7 Migraine; CESC cis rs67311347 1.000 rs11715214 chr3:40403004 C/A cg24209194 chr3:40518798 ZNF619 0.42 5.31 0.31 2.36e-7 Renal cell carcinoma; CESC cis rs8002861 0.905 rs12873099 chr13:44396247 G/A cg14210620 chr13:44453864 C13orf31;CCDC122 -0.45 -5.49 -0.32 9.56e-8 Leprosy; CESC trans rs2727020 0.658 rs10839278 chr11:49450847 G/C cg03929089 chr4:120376271 NA -0.82 -12.73 -0.62 2.68e-29 Coronary artery disease; CESC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg11764359 chr7:65958608 NA -0.81 -9.98 -0.52 4.19e-20 Aortic root size; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25360212 chr19:1095536 POLR2E -0.44 -6.28 -0.36 1.36e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg24675658 chr1:53192096 ZYG11B -0.59 -7.51 -0.42 9.17e-13 Monocyte count; CESC cis rs12956009 0.518 rs983095 chr18:44899258 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.46 0.37 5.1e-10 Educational attainment (years of education); CESC cis rs709400 0.643 rs11621777 chr14:104072090 A/G cg24130564 chr14:104152367 KLC1 -0.42 -5.03 -0.3 9.09e-7 Body mass index; CESC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04203298 chr11:59521722 STX3 -0.38 -6.12 -0.35 3.43e-9 Gambling; CESC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg09323728 chr8:95962352 TP53INP1 -0.39 -8.54 -0.46 1.04e-15 Type 2 diabetes; CESC cis rs4889855 0.511 rs9908700 chr17:78466594 A/G cg00066239 chr17:78472159 NA -0.4 -5.46 -0.32 1.11e-7 Fractional excretion of uric acid; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg24419099 chr11:47270565 NR1H3;ACP2 -0.46 -6.22 -0.36 1.92e-9 Height; CESC cis rs10918270 1.000 rs2341471 chr1:161924749 C/T cg19735514 chr1:161762739 ATF6 -0.36 -5.47 -0.32 1.03e-7 Parkinson's disease (age of onset); CESC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg04455712 chr21:45112962 RRP1B 0.4 5.95 0.34 8.63e-9 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24608144 chr20:62398219 ZBTB46 -0.57 -6.08 -0.35 4.1e-9 Gut microbiome composition (summer); CESC cis rs7017914 0.967 rs1838393 chr8:71702591 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.3 -0.31 2.38e-7 Bone mineral density; CESC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg12463550 chr7:65579703 CRCP -0.6 -7.51 -0.42 9.32e-13 Aortic root size; CESC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg07167872 chr1:205819463 PM20D1 0.43 6.59 0.38 2.34e-10 Menarche (age at onset); CESC cis rs9325144 0.647 rs12424190 chr12:39111206 A/T cg26384229 chr12:38710491 ALG10B -0.52 -7.35 -0.41 2.39e-12 Morning vs. evening chronotype; CESC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg10800226 chr5:1850261 NA 0.34 5.61 0.33 4.97e-8 Cardiovascular disease risk factors; CESC cis rs7071206 0.853 rs66786803 chr10:79429941 A/G cg00983440 chr10:79422392 NA -0.63 -7.78 -0.43 1.61e-13 Bone mineral density; CESC cis rs6540556 0.769 rs7521461 chr1:209926207 C/G cg23920097 chr1:209922102 NA -0.36 -5.2 -0.3 4.02e-7 Red blood cell count; CESC cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg18876405 chr7:65276391 NA 0.51 6.85 0.39 5.1e-11 Aortic root size; CESC cis rs9611565 0.722 rs202635 chr22:41809637 C/T cg17376030 chr22:41985996 PMM1 -0.59 -6.24 -0.36 1.69e-9 Vitiligo; CESC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg00684032 chr4:1343700 KIAA1530 0.39 5.43 0.32 1.27e-7 Obesity-related traits; CESC cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.71 8.96 0.48 5.78e-17 Multiple sclerosis; CESC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg04944784 chr2:26401820 FAM59B 0.96 10.5 0.54 8.76e-22 Gut microbiome composition (summer); CESC trans rs11098499 0.865 rs4001305 chr4:120359236 G/T cg25214090 chr10:38739885 LOC399744 0.71 10.05 0.53 2.33e-20 Corneal astigmatism; CESC cis rs11997175 0.766 rs6995220 chr8:33708919 C/A ch.8.33884649F chr8:33765107 NA 0.44 5.64 0.33 4.37e-8 Body mass index; CESC cis rs3862435 0.572 rs2601165 chr15:90908934 C/G cg22089800 chr15:90895588 ZNF774 -0.47 -5.04 -0.3 8.55e-7 Response to exercise (triglyceride level interaction); CESC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs9443645 0.527 rs9350792 chr6:79587173 A/G cg05283184 chr6:79620031 NA -0.37 -5.2 -0.3 4.08e-7 Intelligence (multi-trait analysis); CESC cis rs959260 0.925 rs4788890 chr17:73389446 A/G cg20590849 chr17:73267439 MIF4GD -0.57 -6.41 -0.37 6.55e-10 Systemic lupus erythematosus; CESC cis rs3768617 0.510 rs1886499 chr1:183095024 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs763512 0.532 rs1416 chr17:35894811 T/C cg16670864 chr17:35848621 DUSP14 0.43 5.2 0.3 4.03e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25804860 chr16:47178250 NETO2 0.45 6.29 0.36 1.31e-9 Systemic lupus erythematosus; CESC cis rs9303401 0.659 rs35828828 chr17:56718205 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.04 12.96 0.62 4.37e-30 Cognitive test performance; CESC cis rs7818688 0.585 rs2599715 chr8:96046493 G/C cg16049864 chr8:95962084 TP53INP1 -0.46 -5.25 -0.31 3.16e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs763121 0.744 rs5757140 chr22:38957013 T/C cg06022373 chr22:39101656 GTPBP1 0.82 11.72 0.58 8.04e-26 Menopause (age at onset); CESC cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.54 5.34 0.31 1.98e-7 Cerebrospinal P-tau181p levels; CESC cis rs12893597 0.715 rs12896100 chr14:76825064 C/T cg20290672 chr14:76816747 NA -0.42 -5.88 -0.34 1.21e-8 Maximal oxygen uptake response; CESC cis rs11112613 0.713 rs55646142 chr12:105949557 G/A cg03607813 chr12:105948248 NA 0.67 8.31 0.45 5.16e-15 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs9902453 0.845 rs62068583 chr17:28001482 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.78 0.47 2.13e-16 Coffee consumption (cups per day); CESC cis rs734999 0.524 rs4648448 chr1:2695687 C/T cg18854424 chr1:2615690 NA 0.3 5.76 0.33 2.28e-8 Ulcerative colitis; CESC cis rs16854884 0.632 rs4535221 chr3:143658607 A/G cg01302019 chr3:143689584 C3orf58 -0.34 -5.08 -0.3 7.26e-7 Economic and political preferences (feminism/equality); CESC trans rs2727020 0.521 rs7126835 chr11:49594658 T/C cg15704280 chr7:45808275 SEPT13 -0.87 -10.71 -0.55 1.73e-22 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23594427 chr12:56367798 RAB5B -0.57 -6.91 -0.39 3.68e-11 Gut microbiome composition (summer); CESC cis rs11785693 0.862 rs11786186 chr8:4999059 G/C cg26367366 chr8:4980734 NA 0.84 7.89 0.44 7.8e-14 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -5.08 -0.3 7.02e-7 Bipolar disorder; CESC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.28 0.41 3.85e-12 Height; CESC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs4727027 0.870 rs13237714 chr7:148884083 A/G cg23583168 chr7:148888333 NA -0.82 -12.56 -0.61 1.03e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg05340658 chr4:99064831 C4orf37 0.86 13.1 0.63 1.39e-30 Colonoscopy-negative controls vs population controls; CESC cis rs66887589 0.592 rs28580295 chr4:120278873 C/T cg09307838 chr4:120376055 NA 0.66 9.21 0.49 1.05e-17 Diastolic blood pressure; CESC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg08859206 chr1:53392774 SCP2 -0.66 -8.98 -0.48 5.34e-17 Monocyte count; CESC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg08859206 chr1:53392774 SCP2 -0.58 -7.68 -0.43 3.09e-13 Monocyte count; CESC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg27170947 chr2:26402098 FAM59B 0.84 9.95 0.52 4.86e-20 Gut microbiome composition (summer); CESC cis rs2455799 0.613 rs13096622 chr3:15837656 A/G cg16303742 chr3:15540471 COLQ -0.39 -6.08 -0.35 4.27e-9 Mean platelet volume; CESC cis rs34779708 0.702 rs7087150 chr10:35542138 A/T cg03585969 chr10:35415529 CREM 0.56 6.42 0.37 6.15e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs6831352 0.693 rs2602875 chr4:100039495 C/G cg12011299 chr4:100065546 ADH4 0.57 6.88 0.39 4.34e-11 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15921012 chr3:15919793 NA -0.7 -8.38 -0.46 3.06e-15 Gut microbiome composition (summer); CESC cis rs8103278 1.000 rs8109951 chr19:46289503 C/T cg12641515 chr19:46296257 DMWD -0.51 -5.83 -0.34 1.6e-8 Coronary artery disease; CESC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.58 -0.37 2.56e-10 Intelligence (multi-trait analysis); CESC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.55 6.62 0.38 1.99e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15229027 chr14:64805542 ESR2 0.49 6.21 0.36 2.08e-9 Gut microbiota (bacterial taxa); CESC cis rs7246865 0.510 rs1130222 chr19:17170885 C/T cg16202187 chr19:17186497 HAUS8;MYO9B 0.48 6.26 0.36 1.56e-9 Reticulocyte fraction of red cells; CESC cis rs3820068 0.608 rs7519899 chr1:16045579 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.75 0.33 2.45e-8 Systolic blood pressure; CESC cis rs7216064 1.000 rs7212293 chr17:65847325 A/G cg12091567 chr17:66097778 LOC651250 -0.78 -9.2 -0.49 1.08e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7772486 0.790 rs9497427 chr6:146238302 T/A cg23711669 chr6:146136114 FBXO30 -0.82 -11.64 -0.58 1.47e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs1707322 1.000 rs12133129 chr1:46373348 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7582720 1.000 rs72936309 chr2:204040296 G/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 6.87 0.39 4.55e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg16325326 chr1:53192061 ZYG11B 0.82 12.71 0.62 3.3e-29 Monocyte count; CESC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.43 -0.32 1.28e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs12928939 0.517 rs11865456 chr16:71969497 C/T cg03805757 chr16:71968109 PKD1L3 -0.56 -6.37 -0.36 8.44e-10 Post bronchodilator FEV1; CESC cis rs9811920 0.609 rs4244713 chr3:99679584 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.64 -10.1 -0.53 1.62e-20 Axial length; CESC cis rs6088580 0.634 rs62212172 chr20:32987705 G/A cg06115741 chr20:33292138 TP53INP2 -0.47 -6.14 -0.35 3.06e-9 Glomerular filtration rate (creatinine); CESC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg17372223 chr3:52568218 NT5DC2 0.43 6.46 0.37 5.04e-10 Bipolar disorder; CESC cis rs9916302 0.861 rs3889368 chr17:37683231 C/T cg20243544 chr17:37824526 PNMT 0.48 6.04 0.35 5.25e-9 Glomerular filtration rate (creatinine); CESC cis rs9359856 0.510 rs17294495 chr6:90445753 T/G cg13799429 chr6:90582589 CASP8AP2 -0.7 -7.8 -0.43 1.46e-13 Bipolar disorder; CESC cis rs57506017 0.585 rs7792410 chr7:12267614 A/G cg23422036 chr7:12250390 TMEM106B 0.4 5.43 0.32 1.26e-7 Neuroticism; CESC cis rs11122272 0.735 rs2474625 chr1:231519331 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg26597838 chr10:835615 NA 0.9 9.68 0.51 3.52e-19 Eosinophil percentage of granulocytes; CESC cis rs796364 0.755 rs203762 chr2:200905136 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC cis rs9811920 0.535 rs704572 chr3:99482314 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.33 -5.29 -0.31 2.59e-7 Axial length; CESC trans rs3942852 0.568 rs10769313 chr11:48097466 A/G cg03929089 chr4:120376271 NA -0.63 -7.77 -0.43 1.78e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs892961 0.932 rs3987885 chr17:75414990 A/G cg05865280 chr17:75406074 SEPT9 0.62 12.5 0.61 1.7e-28 Airflow obstruction; CESC cis rs9818941 0.824 rs1123115 chr3:157813401 C/T cg08654915 chr3:157813417 NA 0.5 7.92 0.44 6.5e-14 Height; CESC cis rs10754283 0.967 rs10801763 chr1:90120822 C/T cg21401794 chr1:90099060 LRRC8C 0.66 8.77 0.47 2.18e-16 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg24733560 chr20:60626293 TAF4 -0.5 -7.45 -0.42 1.31e-12 Body mass index; CESC cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg13298116 chr11:62369859 EML3;MTA2 0.55 7.51 0.42 9.28e-13 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC trans rs1814175 0.817 rs7109440 chr11:49966296 C/T cg03929089 chr4:120376271 NA -0.93 -15.75 -0.7 6.66e-40 Height; CESC cis rs11608355 0.515 rs11609630 chr12:109918934 C/T cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs7843479 1.000 rs10503715 chr8:21850687 G/A cg17168535 chr8:21777572 XPO7 0.48 6.74 0.38 9.97e-11 Mean corpuscular volume; CESC cis rs12142240 0.738 rs41293275 chr1:46806429 A/T cg00530320 chr1:46809349 NSUN4 0.59 7.85 0.43 1.02e-13 Menopause (age at onset); CESC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.54 -0.32 7.16e-8 Lung cancer; CESC cis rs933688 1.000 rs10474353 chr5:90732285 A/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.13 14.43 0.66 3.18e-35 Smoking behavior; CESC cis rs1577917 0.771 rs4145082 chr6:86352016 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -6.89 -0.39 3.97e-11 Response to antipsychotic treatment; CESC cis rs7116495 1.000 rs4944258 chr11:71743393 T/A cg10381502 chr11:71823885 C11orf51 -0.68 -5.65 -0.33 4.05e-8 Severe influenza A (H1N1) infection; CESC trans rs11098499 0.863 rs28718422 chr4:120466304 C/A cg25214090 chr10:38739885 LOC399744 0.67 9.21 0.49 1.05e-17 Corneal astigmatism; CESC cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.41 -5.43 -0.32 1.29e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7301826 0.651 rs7968675 chr12:131303377 C/T cg11011512 chr12:131303247 STX2 0.44 5.4 0.31 1.48e-7 Plasma plasminogen activator levels; CESC cis rs1371867 0.875 rs1660320 chr8:101337579 A/C cg11906718 chr8:101322791 RNF19A 0.47 6.03 0.35 5.36e-9 Atrioventricular conduction; CESC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg05025164 chr4:1340916 KIAA1530 0.64 8.68 0.47 4.15e-16 Longevity; CESC cis rs4604732 0.631 rs60311891 chr1:247623127 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.5 6.29 0.36 1.31e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1790761 0.554 rs12787511 chr11:67401635 G/C cg14500267 chr11:67383377 NA -0.34 -5.14 -0.3 5.33e-7 Mean corpuscular volume; CESC cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.09 0.3 6.92e-7 Personality dimensions; CESC cis rs8072100 0.967 rs4580230 chr17:45738861 G/A cg08085267 chr17:45401833 C17orf57 -0.43 -5.75 -0.33 2.45e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9815354 0.953 rs6795797 chr3:41862250 A/G cg03022575 chr3:42003672 ULK4 0.45 5.15 0.3 5.19e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7818688 0.929 rs28419772 chr8:96021436 A/T cg16049864 chr8:95962084 TP53INP1 0.61 5.74 0.33 2.62e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1832871 0.711 rs9459924 chr6:158703902 G/A cg07165851 chr6:158734300 TULP4 0.61 6.52 0.37 3.57e-10 Height; CESC cis rs1670533 1.000 rs1670533 chr4:1078187 G/A cg27284194 chr4:1044797 NA 0.47 5.91 0.34 1.04e-8 Recombination rate (females); CESC cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg15017067 chr4:17643749 FAM184B -0.37 -5.45 -0.32 1.13e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.78 -0.33 2.1e-8 Developmental language disorder (linguistic errors); CESC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg26335602 chr6:28129616 ZNF389 0.44 5.61 0.33 5.19e-8 Parkinson's disease; CESC cis rs9320282 0.587 rs1546721 chr6:109625796 T/C cg01475377 chr6:109611718 NA -0.34 -5.23 -0.31 3.46e-7 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs2629540 0.847 rs12247543 chr10:126419743 G/C cg08799069 chr10:126477246 METTL10 0.63 8.2 0.45 1.06e-14 Cocaine dependence; CESC cis rs2991971 0.716 rs7532573 chr1:45915892 A/T cg15605315 chr1:45957053 TESK2 -0.39 -5.32 -0.31 2.25e-7 High light scatter reticulocyte count; CESC cis rs8050907 0.744 rs17879291 chr16:4526104 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg16262614 chr3:133464971 TF 0.42 8.35 0.46 3.82e-15 Iron status biomarkers (transferrin levels); CESC cis rs6964587 1.000 rs28410528 chr7:91647390 A/G cg17063962 chr7:91808500 NA 0.58 8.02 0.44 3.36e-14 Breast cancer; CESC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg10862848 chr6:42927986 GNMT -0.27 -6.48 -0.37 4.36e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.04 -0.4 1.68e-11 Personality dimensions; CESC cis rs7584330 0.780 rs2292884 chr2:238443226 A/G cg06639874 chr2:238417703 MLPH -0.39 -5.32 -0.31 2.24e-7 Prostate cancer; CESC cis rs2073300 0.609 rs6137915 chr20:23358509 A/G cg16736954 chr20:23401023 NAPB -0.78 -5.96 -0.34 7.85e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6687430 0.532 rs4846235 chr1:10632235 C/T cg20482658 chr1:10539492 PEX14 0.39 7.96 0.44 5e-14 Hand grip strength; CESC cis rs7116495 0.609 rs73531955 chr11:71687794 A/C cg07596299 chr11:71824057 C11orf51 0.82 5.24 0.31 3.32e-7 Severe influenza A (H1N1) infection; CESC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg12463550 chr7:65579703 CRCP 0.49 6.33 0.36 1.03e-9 Aortic root size; CESC cis rs72634258 0.740 rs6665452 chr1:8172492 A/T cg00042356 chr1:8021962 PARK7 -0.48 -5.26 -0.31 2.94e-7 Inflammatory bowel disease; CESC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs965469 0.779 rs6139071 chr20:3299054 A/G cg17110299 chr20:3385021 C20orf194 0.38 5.19 0.3 4.17e-7 IFN-related cytopenia; CESC cis rs1005277 0.522 rs1208681 chr10:38092975 C/T cg25427524 chr10:38739819 LOC399744 -0.64 -9.79 -0.52 1.61e-19 Extrinsic epigenetic age acceleration; CESC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg11764359 chr7:65958608 NA -0.81 -11.72 -0.58 8.04e-26 Aortic root size; CESC cis rs12618769 0.625 rs61180742 chr2:99148078 A/G cg10123293 chr2:99228465 UNC50 0.39 5.17 0.3 4.62e-7 Bipolar disorder; CESC cis rs17021463 0.934 rs28403447 chr4:95257753 G/A cg11021082 chr4:95130006 SMARCAD1 0.53 7.99 0.44 4.23e-14 Testicular germ cell tumor; CESC cis rs1144333 0.655 rs11162053 chr1:76470267 A/C cg10523679 chr1:76189770 ACADM 0.58 5.36 0.31 1.84e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs2204008 0.775 rs11514369 chr12:38305411 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Bladder cancer; CESC cis rs9611565 0.559 rs8139993 chr22:41995335 T/C cg06634786 chr22:41940651 POLR3H -0.55 -6.04 -0.35 5.06e-9 Vitiligo; CESC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg27165867 chr14:105738592 BRF1 -0.53 -6.04 -0.35 5.29e-9 Mean platelet volume;Platelet distribution width; CESC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg03609598 chr5:56110824 MAP3K1 -0.52 -5.61 -0.33 5.04e-8 Initial pursuit acceleration; CESC cis rs4141404 0.651 rs5753723 chr22:32002294 T/C cg13145458 chr22:31556086 RNF185 0.55 5.44 0.32 1.19e-7 Paclitaxel-induced neuropathy; CESC cis rs8072100 0.748 rs9912592 chr17:45556945 G/A cg25173405 chr17:45401733 C17orf57 -0.47 -6.15 -0.35 2.91e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg07414643 chr4:187882934 NA 0.54 7.78 0.43 1.65e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.875 rs1331637 chr6:146337087 T/C cg23711669 chr6:146136114 FBXO30 0.86 12.53 0.61 1.39e-28 Lobe attachment (rater-scored or self-reported); CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg01640215 chr16:21312637 CRYM;NCRNA00169 0.46 6.14 0.35 3.06e-9 Positive affect; CESC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg04414720 chr1:150670196 GOLPH3L 0.5 6.57 0.37 2.71e-10 Melanoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10117958 chr1:161719605 DUSP12 0.55 6.05 0.35 4.98e-9 Gut microbiome composition (summer); CESC cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg13072238 chr3:49761600 GMPPB -0.51 -5.98 -0.35 7.05e-9 Menarche (age at onset); CESC cis rs3106136 0.609 rs4693000 chr4:95107657 T/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.29 -0.36 1.34e-9 Capecitabine sensitivity; CESC cis rs12142240 0.698 rs6659228 chr1:46811027 C/G cg00530320 chr1:46809349 NSUN4 0.57 7.77 0.43 1.78e-13 Menopause (age at onset); CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg07628558 chr20:56964831 VAPB -0.56 -6.23 -0.36 1.85e-9 Lung cancer in ever smokers; CESC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg23758822 chr17:41437982 NA 1.03 18.97 0.76 2.72e-51 Menopause (age at onset); CESC cis rs1707322 1.000 rs6687301 chr1:46382852 T/C cg06784218 chr1:46089804 CCDC17 0.32 5.5 0.32 8.73e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2070433 0.800 rs11700596 chr21:47874054 G/C cg12379764 chr21:47803548 PCNT 0.66 7.47 0.42 1.13e-12 Lymphocyte counts; CESC cis rs9747201 1.000 rs58119191 chr17:80155329 T/C cg09264619 chr17:80180166 NA -0.42 -5.05 -0.3 8.04e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7786808 0.712 rs2335170 chr7:158207101 G/A cg09998033 chr7:158218633 PTPRN2 -0.4 -5.73 -0.33 2.77e-8 Obesity-related traits; CESC cis rs2354432 0.607 rs3820130 chr1:146724003 A/G cg25205988 chr1:146714368 CHD1L -0.93 -8.41 -0.46 2.49e-15 Mitochondrial DNA levels; CESC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg15052019 chr19:19431593 KIAA0892;SF4 -0.42 -5.39 -0.31 1.53e-7 Tonsillectomy; CESC cis rs9291683 0.509 rs10939671 chr4:10050815 T/C cg11266682 chr4:10021025 SLC2A9 0.64 12.48 0.61 1.98e-28 Bone mineral density; CESC cis rs2235642 0.826 rs8053605 chr16:1594158 G/A cg03771183 chr16:1608904 IFT140 0.41 5.9 0.34 1.08e-8 Coronary artery disease; CESC trans rs11098499 0.909 rs7681978 chr4:120383775 T/C cg25214090 chr10:38739885 LOC399744 0.69 9.79 0.52 1.58e-19 Corneal astigmatism; CESC cis rs8016982 0.674 rs3815953 chr14:81685482 G/A cg01989461 chr14:81687754 GTF2A1 0.74 11.59 0.58 2.13e-25 Schizophrenia; CESC cis rs9584850 0.794 rs9630321 chr13:99106979 C/G cg22223119 chr13:99095684 FARP1 -0.36 -5.15 -0.3 5.06e-7 Neuroticism; CESC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.81 0.39 6.37e-11 Bipolar disorder; CESC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg00149659 chr3:10157352 C3orf10 0.73 9.16 0.49 1.43e-17 Alzheimer's disease; CESC cis rs7103648 0.545 rs6485795 chr11:47929846 G/A cg10504702 chr11:47789108 FNBP4 0.44 5.52 0.32 7.99e-8 Diastolic blood pressure;Systolic blood pressure; CESC cis rs10845606 1.000 rs10845609 chr12:12838920 T/A cg09462578 chr12:12878428 APOLD1 -0.66 -7.19 -0.4 6.75e-12 Systemic lupus erythematosus; CESC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg06420487 chr17:61919686 SMARCD2 0.46 5.52 0.32 8.05e-8 Height; CESC cis rs9640161 0.789 rs10282458 chr7:150045302 C/T cg10018233 chr7:150070692 REPIN1 0.38 5.65 0.33 4.24e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs72781680 0.898 rs72788302 chr2:24107246 C/T cg08917208 chr2:24149416 ATAD2B 1.11 10.18 0.53 9.57e-21 Lymphocyte counts; CESC cis rs10781543 0.839 rs7863766 chr9:139381314 T/G cg14169450 chr9:139327907 INPP5E 0.51 7.83 0.43 1.18e-13 Monocyte percentage of white cells; CESC cis rs7264396 0.676 rs6058383 chr20:34556005 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.2 0.36 2.18e-9 Total cholesterol levels; CESC trans rs7618501 0.902 rs7645061 chr3:49868842 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.32 0.46 4.72e-15 Intelligence (multi-trait analysis); CESC trans rs9354308 0.899 rs1938059 chr6:66539291 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 6.66 0.38 1.6e-10 Metabolite levels; CESC cis rs2228479 0.850 rs62054224 chr16:89892071 C/T cg06558623 chr16:89946397 TCF25 1.04 7.85 0.43 1.03e-13 Skin colour saturation; CESC cis rs13255475 0.772 rs4545141 chr8:121498963 T/C cg05978010 chr8:121408224 MRPL13 -0.36 -5.62 -0.33 4.89e-8 Cerebrospinal T-tau levels;Cerebrospinal P-tau181p levels; CESC cis rs11122272 0.706 rs2749710 chr1:231535112 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.6 8.23 0.45 8.79e-15 Hemoglobin concentration; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg23131131 chr22:24373011 LOC391322 -0.67 -8.99 -0.48 4.67e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg00149659 chr3:10157352 C3orf10 0.7 8.38 0.46 3.2e-15 Alzheimer's disease; CESC cis rs1707322 1.000 rs11211219 chr1:46359478 G/C cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8111998 0.826 rs60316370 chr19:22764743 T/C cg19914732 chr19:22715077 NA -0.37 -5.09 -0.3 6.68e-7 Corneal structure; CESC cis rs12472274 0.646 rs11677736 chr2:239087198 A/T cg17459225 chr2:239074497 NA 0.47 5.67 0.33 3.7e-8 Phospholipid levels (plasma); CESC cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.52 0.46 1.24e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03658244 chr18:32621088 MAPRE2 -0.52 -6.27 -0.36 1.44e-9 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -5.7 -0.33 3.12e-8 Extrinsic epigenetic age acceleration; CESC cis rs14403 0.874 rs3006924 chr1:243650986 G/C cg21452805 chr1:244014465 NA 0.46 5.27 0.31 2.89e-7 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18105612 chr14:71289522 NA -0.48 -6.23 -0.36 1.85e-9 Ulcerative colitis; CESC cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3015497 0.603 rs2934675 chr14:51082217 C/T cg26011998 chr14:51135199 SAV1 -0.46 -5.16 -0.3 4.91e-7 Mean platelet volume; CESC cis rs2479106 0.591 rs4836939 chr9:126403866 G/A cg16191174 chr9:126692580 DENND1A 0.39 5.28 0.31 2.65e-7 Polycystic ovary syndrome; CESC cis rs12477438 0.765 rs6749059 chr2:99591021 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.99 -0.56 2.08e-23 Chronic sinus infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12460765 chr7:2415105 EIF3B 0.48 7.01 0.4 1.99e-11 Fibrinogen levels; CESC cis rs2645424 0.666 rs2272767 chr8:11711059 C/T cg21281001 chr8:11725306 CTSB 0.56 6.8 0.39 6.99e-11 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); CESC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg25072359 chr17:41440525 NA 0.44 5.88 0.34 1.23e-8 Menopause (age at onset); CESC cis rs11997175 0.624 rs4526317 chr8:33682936 T/A ch.8.33884649F chr8:33765107 NA 0.57 7.29 0.41 3.65e-12 Body mass index; CESC cis rs7582720 1.000 rs72934753 chr2:203750272 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg05564831 chr3:52568323 NT5DC2 0.47 7.48 0.42 1.12e-12 Bipolar disorder; CESC cis rs4472734 0.830 rs12736454 chr1:214629641 G/A cg00063699 chr1:214624242 PTPN14 -0.34 -5.12 -0.3 5.78e-7 Height; CESC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg14829155 chr15:31115871 NA -0.73 -9.94 -0.52 5.42e-20 Huntington's disease progression; CESC cis rs1538970 0.962 rs2487442 chr1:45857176 C/G cg06784218 chr1:46089804 CCDC17 -0.3 -5.11 -0.3 6.1e-7 Platelet count; CESC cis rs17539620 0.624 rs871068 chr6:154837514 C/A cg20019720 chr6:154832845 CNKSR3 0.47 6.13 0.35 3.21e-9 Lipoprotein (a) levels; CESC cis rs4450131 0.522 rs3781460 chr10:126342919 A/G cg20435097 chr10:126320824 FAM53B -0.28 -5.12 -0.3 5.82e-7 White blood cell count (basophil); CESC cis rs6540556 0.724 rs6679631 chr1:209935491 C/A cg23920097 chr1:209922102 NA -0.37 -5.59 -0.32 5.64e-8 Red blood cell count; CESC cis rs10504229 0.679 rs4738574 chr8:58033771 T/C cg22535103 chr8:58192502 C8orf71 -0.61 -6.86 -0.39 4.87e-11 Developmental language disorder (linguistic errors); CESC cis rs2180341 0.695 rs6569487 chr6:127726196 C/T cg27446573 chr6:127587934 RNF146 -0.72 -10.51 -0.54 8.07e-22 Breast cancer; CESC cis rs3125734 0.571 rs7100401 chr10:64024417 C/G cg09941381 chr10:64027924 RTKN2 -0.32 -5.21 -0.3 3.89e-7 Rheumatoid arthritis; CESC cis rs2204008 0.775 rs3900361 chr12:38238936 A/G cg26384229 chr12:38710491 ALG10B -0.66 -9.24 -0.49 8.25e-18 Bladder cancer; CESC cis rs731174 0.959 rs7527344 chr1:38191560 C/A cg06917450 chr1:38156652 C1orf109 -0.44 -5.45 -0.32 1.17e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7267979 0.816 rs390123 chr20:25480105 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.46 0.66 2.44e-35 Liver enzyme levels (alkaline phosphatase); CESC cis rs9457247 0.534 rs12055488 chr6:167379570 A/G cg25258033 chr6:167368657 RNASET2 -0.39 -5.7 -0.33 3.21e-8 Crohn's disease; CESC cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg20503657 chr10:835505 NA 0.83 8.19 0.45 1.1e-14 Eosinophil percentage of granulocytes; CESC trans rs11098499 0.954 rs11098526 chr4:120390359 C/T cg25214090 chr10:38739885 LOC399744 0.72 10.22 0.53 7.13e-21 Corneal astigmatism; CESC cis rs926938 0.527 rs7526844 chr1:115543759 T/C cg12756093 chr1:115239321 AMPD1 0.44 6.13 0.35 3.24e-9 Autism; CESC cis rs2294693 0.945 rs742494 chr6:41007835 A/T cg14418226 chr6:40996092 UNC5CL 0.52 5.98 0.34 7.18e-9 Gastric cancer;Non-cardia gastric cancer; CESC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg15782153 chr7:917662 C7orf20 -0.47 -5.07 -0.3 7.57e-7 Cerebrospinal P-tau181p levels; CESC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg04414720 chr1:150670196 GOLPH3L 0.58 7.55 0.42 7.07e-13 Melanoma; CESC cis rs1707322 0.721 rs12091503 chr1:46107868 T/C cg06784218 chr1:46089804 CCDC17 0.42 7.35 0.41 2.41e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2066819 1.000 rs75265219 chr12:56640341 G/A cg26734620 chr12:56694298 CS 1.04 6.73 0.38 1.06e-10 Psoriasis vulgaris; CESC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg19046167 chr17:80928561 B3GNTL1 0.48 5.85 0.34 1.43e-8 Glycated hemoglobin levels; CESC cis rs17401966 0.838 rs6541089 chr1:10402785 A/G cg15208524 chr1:10270712 KIF1B 0.4 5.12 0.3 5.76e-7 Hepatocellular carcinoma; CESC cis rs3749237 0.595 rs7643845 chr3:49530711 A/G cg07636037 chr3:49044803 WDR6 0.61 8.81 0.48 1.66e-16 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02602601 chr12:56618057 OBFC2B 0.57 6.67 0.38 1.45e-10 Gut microbiome composition (summer); CESC cis rs854765 0.583 rs7213225 chr17:17869111 T/C cg16928487 chr17:17741425 SREBF1 -0.57 -9.55 -0.51 9.29e-19 Total body bone mineral density; CESC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg24399712 chr22:39784796 NA -0.82 -10.17 -0.53 1.01e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs416603 0.967 rs7191538 chr16:11363389 C/G cg00044050 chr16:11439710 C16orf75 -0.42 -5.18 -0.3 4.31e-7 Type 1 diabetes; CESC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.09 0.6 4.37e-27 Alzheimer's disease; CESC cis rs12497850 0.931 rs3774628 chr3:48801840 C/T cg03060546 chr3:49711283 APEH 0.42 5.28 0.31 2.73e-7 Parkinson's disease; CESC cis rs6987853 0.563 rs2974302 chr8:42443119 C/G cg09913449 chr8:42400586 C8orf40 0.33 5.12 0.3 5.91e-7 Mean corpuscular hemoglobin concentration; CESC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg25072359 chr17:41440525 NA 0.43 5.78 0.33 2.04e-8 Menopause (age at onset); CESC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg11247378 chr22:39784982 NA -0.62 -9.14 -0.49 1.74e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs2228479 0.718 rs11645376 chr16:89912281 G/C cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs9611565 0.729 rs137831 chr22:41903813 A/C cg03806693 chr22:41940476 POLR3H -0.89 -11.57 -0.58 2.44e-25 Vitiligo; CESC cis rs12155623 0.619 rs17641604 chr8:49842784 C/T cg00325661 chr8:49890786 NA 0.41 5.78 0.33 2.05e-8 Sudden cardiac arrest; CESC cis rs6570726 0.935 rs454614 chr6:145832633 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2204008 0.744 rs2222344 chr12:38406832 T/G cg13010199 chr12:38710504 ALG10B 0.45 5.86 0.34 1.39e-8 Bladder cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25631650 chr19:633157 POLRMT 0.51 6.55 0.37 2.96e-10 Gut microbiota (bacterial taxa); CESC cis rs9303280 0.936 rs12950209 chr17:38049102 T/C cg20243544 chr17:37824526 PNMT 0.52 6.93 0.39 3.13e-11 Self-reported allergy; CESC cis rs72781680 1.000 rs61739076 chr2:24149439 G/A cg08917208 chr2:24149416 ATAD2B 1.1 9.84 0.52 1.09e-19 Lymphocyte counts; CESC cis rs6088580 0.634 rs3736762 chr20:33037336 C/T cg06115741 chr20:33292138 TP53INP2 0.47 6.1 0.35 3.84e-9 Glomerular filtration rate (creatinine); CESC cis rs2737618 0.651 rs2816974 chr1:200082686 C/G cg21825944 chr1:200113062 NR5A2 0.45 6.82 0.39 6.19e-11 Uric acid levels; CESC trans rs8007846 0.569 rs4400971 chr14:66254578 A/C cg21543045 chr12:108154206 PRDM4 0.46 6.06 0.35 4.55e-9 Multiple sclerosis--Brain Glutamate Levels; CESC cis rs67460515 0.563 rs11713441 chr3:160906855 T/C cg03342759 chr3:160939853 NMD3 -0.53 -7.05 -0.4 1.57e-11 Parkinson's disease; CESC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg24549020 chr5:56110836 MAP3K1 0.57 6.8 0.39 6.91e-11 Initial pursuit acceleration; CESC cis rs854765 0.583 rs11869536 chr17:17826528 T/A cg16928487 chr17:17741425 SREBF1 -0.57 -9.74 -0.51 2.41e-19 Total body bone mineral density; CESC cis rs11676348 0.818 rs6436033 chr2:218983763 A/G cg00012203 chr2:219082015 ARPC2 -0.57 -7.32 -0.41 3.02e-12 Ulcerative colitis; CESC cis rs4474465 0.920 rs10899532 chr11:78208470 T/G cg27205649 chr11:78285834 NARS2 0.43 5.54 0.32 7.3900000000000007e-08 Alzheimer's disease (survival time); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11059266 chr4:48782139 FRYL -0.48 -6.56 -0.37 2.85e-10 Fibrinogen levels; CESC cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg10057126 chr4:77819792 ANKRD56 0.58 8.4 0.46 2.79e-15 Emphysema distribution in smoking; CESC cis rs2180341 0.782 rs6912196 chr6:127722732 C/G cg27446573 chr6:127587934 RNF146 0.8 11.41 0.57 8.87e-25 Breast cancer; CESC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.17 -0.63 8.14e-31 Developmental language disorder (linguistic errors); CESC cis rs1843834 0.505 rs2140508 chr2:225355839 G/T cg22509189 chr2:225307070 NA -0.4 -5.41 -0.32 1.38e-7 IgE levels in asthmatics (D.p. specific); CESC cis rs67311347 0.955 rs2085114 chr3:40497437 T/A cg24209194 chr3:40518798 ZNF619 0.5 6.13 0.35 3.12e-9 Renal cell carcinoma; CESC trans rs1728785 1.000 rs1170443 chr16:68573295 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.44 0.42 1.41e-12 Ulcerative colitis; CESC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg18446336 chr7:2847575 GNA12 -0.37 -5.66 -0.33 3.96e-8 Height; CESC cis rs4601821 0.522 rs754672 chr11:113249136 C/T cg14159747 chr11:113255604 NA 0.31 5.52 0.32 8.26e-8 Alcoholic chronic pancreatitis; CESC cis rs17253792 0.822 rs77420254 chr14:56069646 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC trans rs2823962 0.759 rs2823933 chr21:18022418 G/T cg01437917 chr17:4688569 NA -0.44 -6.21 -0.36 2.06e-9 Amyotrophic lateral sclerosis; CESC cis rs2361718 0.500 rs4889818 chr17:78085228 A/G cg14949292 chr17:78079608 GAA -0.37 -5.29 -0.31 2.58e-7 Yeast infection; CESC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg22535103 chr8:58192502 C8orf71 -0.89 -7.42 -0.41 1.54e-12 Developmental language disorder (linguistic errors); CESC trans rs11098499 0.863 rs7699064 chr4:120428309 A/G cg25214090 chr10:38739885 LOC399744 -0.69 -9.58 -0.51 7.3e-19 Corneal astigmatism; CESC trans rs61931739 0.613 rs1817500 chr12:33679809 G/T cg21422208 chr3:53164667 RFT1 0.47 6.0 0.35 6.6e-9 Morning vs. evening chronotype; CESC cis rs752010 0.806 rs4457567 chr1:42091407 C/T cg06885757 chr1:42089581 HIVEP3 0.49 8.24 0.45 8.1e-15 Lupus nephritis in systemic lupus erythematosus; CESC cis rs17401966 1.000 rs7520651 chr1:10329872 G/A cg15208524 chr1:10270712 KIF1B 0.45 5.81 0.34 1.83e-8 Hepatocellular carcinoma; CESC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg17724175 chr1:150552817 MCL1 0.42 6.43 0.37 5.8e-10 Melanoma; CESC cis rs863345 0.584 rs11265018 chr1:158506409 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.82 -0.39 6.1e-11 Pneumococcal bacteremia; CESC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.9 -0.34 1.08e-8 Total body bone mineral density; CESC cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs826838 0.559 rs1843891 chr12:38617018 T/C cg26384229 chr12:38710491 ALG10B 0.46 6.62 0.38 1.96e-10 Heart rate; CESC cis rs9322193 0.884 rs9383865 chr6:150173179 A/G cg07701084 chr6:150067640 NUP43 0.4 5.23 0.31 3.41e-7 Lung cancer; CESC cis rs4523957 0.890 rs11655813 chr17:2119101 C/T cg16513277 chr17:2031491 SMG6 -0.59 -7.92 -0.44 6.51e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.38 -6.14 -0.35 2.97e-9 Cystic fibrosis severity; CESC trans rs4756846 1.000 rs72871390 chr11:16462626 A/G cg05579622 chr5:10618622 ANKRD33B 0.73 6.26 0.36 1.54e-9 Obesity and osteoporosis; CESC cis rs7202877 0.706 rs247437 chr16:75431275 T/G cg04384234 chr16:75411784 CFDP1 0.47 5.75 0.33 2.41e-8 Type 2 diabetes;Type 1 diabetes; CESC trans rs495337 1.000 rs6125829 chr20:48568929 A/C cg17603288 chr5:14405747 TRIO -0.48 -6.07 -0.35 4.53e-9 Psoriasis; CESC cis rs7216064 0.589 rs7213585 chr17:66062316 A/T cg12091567 chr17:66097778 LOC651250 -0.92 -12.37 -0.61 4.66e-28 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7582720 0.943 rs72936866 chr2:203787120 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg07157834 chr1:205819609 PM20D1 -0.42 -5.69 -0.33 3.42e-8 Menarche (age at onset); CESC cis rs67311347 0.822 rs11709089 chr3:40351484 C/T cg09455208 chr3:40491958 NA 0.45 7.6 0.42 5.25e-13 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22875749 chr7:23571782 TRA2A 0.57 6.19 0.36 2.26e-9 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6728642 1.000 rs116171118 chr2:97695036 C/A cg26665480 chr2:98280029 ACTR1B -0.84 -6.63 -0.38 1.83e-10 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs7224668 0.647 rs8070092 chr17:79246818 A/C cg05632623 chr17:78450055 NPTX1 -0.29 -5.13 -0.3 5.59e-7 IgG glycosylation; CESC cis rs611744 0.506 rs4735054 chr8:109261780 A/C cg21045802 chr8:109455806 TTC35 -0.55 -6.78 -0.38 7.84e-11 Dupuytren's disease; CESC cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg05283184 chr6:79620031 NA -0.43 -6.66 -0.38 1.56e-10 Intelligence (multi-trait analysis); CESC cis rs1707322 0.963 rs10789484 chr1:46406978 G/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2290720 0.930 rs7296094 chr12:101689959 A/G cg22051763 chr12:101673672 UTP20 -0.47 -5.81 -0.34 1.8e-8 Brain structure (hippocampal volume); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10066545 chr7:66072065 NA 0.42 6.45 0.37 5.29e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4803468 1.000 rs11880539 chr19:41918949 A/C cg09537434 chr19:41945824 ATP5SL 1.01 17.5 0.73 4.33e-46 Height; CESC cis rs75804782 0.520 rs72987319 chr2:239351143 C/T cg18131467 chr2:239335373 ASB1 -0.67 -5.66 -0.33 3.93e-8 Morning vs. evening chronotype;Chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10799249 chr10:422187 DIP2C 0.45 6.19 0.36 2.33e-9 Fibrinogen levels; CESC cis rs9354308 0.933 rs10455586 chr6:66571498 T/C cg07460842 chr6:66804631 NA 0.68 7.68 0.43 3.08e-13 Metabolite levels; CESC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg00149659 chr3:10157352 C3orf10 0.76 9.05 0.49 3.14e-17 Alzheimer's disease; CESC cis rs6546537 0.571 rs4852274 chr2:69780637 G/A cg10773587 chr2:69614142 GFPT1 -0.52 -6.8 -0.39 7.06e-11 Serum thyroid-stimulating hormone levels; CESC cis rs9911578 0.900 rs8067264 chr17:57182793 G/C cg05425664 chr17:57184151 TRIM37 -0.53 -7.31 -0.41 3.19e-12 Intelligence (multi-trait analysis); CESC trans rs123509 0.913 rs123506 chr3:42775976 T/C cg22035501 chr5:112073398 APC 0.56 6.03 0.35 5.62e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1355223 0.583 rs2915177 chr11:34880266 A/G cg24088639 chr11:34937564 PDHX;APIP -0.41 -5.17 -0.3 4.63e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6964587 0.967 rs6465353 chr7:91779971 G/T cg17063962 chr7:91808500 NA -0.58 -8.03 -0.44 3.25e-14 Breast cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03069383 chr2:18741691 RDH14 -0.5 -7.2 -0.4 6.33e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg20476274 chr7:133979776 SLC35B4 0.68 9.88 0.52 8.59e-20 Mean platelet volume; CESC cis rs870825 0.616 rs6810600 chr4:185616814 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs11153306 0.529 rs11153303 chr6:111937875 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.47 -7.03 -0.4 1.8e-11 Tonsillectomy; CESC cis rs7301826 0.610 rs9668291 chr12:131296908 C/G cg11011512 chr12:131303247 STX2 0.46 5.65 0.33 4.22e-8 Plasma plasminogen activator levels; CESC cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.77 8.27 0.45 6.58e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4233802 1.000 rs7563730 chr2:151132697 A/G cg25300694 chr2:151184358 NA 0.93 7.83 0.43 1.14e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs28374715 0.532 rs28535540 chr15:41659277 G/A cg18705301 chr15:41695430 NDUFAF1 -1.04 -16.57 -0.71 8.28e-43 Ulcerative colitis; CESC cis rs7917772 0.503 rs7068535 chr10:104349127 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.33 -0.36 1.07e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs11958404 0.789 rs78112793 chr5:157428226 A/G cg05962755 chr5:157440814 NA 0.61 6.41 0.37 6.49e-10 IgG glycosylation; CESC cis rs17376456 0.809 rs12152763 chr5:93405509 T/A cg25358565 chr5:93447407 FAM172A 1.16 10.8 0.55 8.82e-23 Diabetic retinopathy; CESC cis rs6942756 0.659 rs624118 chr7:129096653 C/T cg02491457 chr7:128862824 NA -0.58 -8.17 -0.45 1.27e-14 White matter hyperintensity burden; CESC cis rs13082711 0.522 rs574955 chr3:27351000 T/C cg02860705 chr3:27208620 NA 0.4 5.25 0.31 3.11e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs2991971 0.901 rs11211122 chr1:45954650 C/T cg05343316 chr1:45956843 TESK2 -0.49 -6.41 -0.37 6.46e-10 High light scatter reticulocyte count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11989253 chr2:26987185 C2orf18 -0.5 -6.26 -0.36 1.55e-9 Ulcerative colitis; CESC cis rs3733418 0.860 rs13110286 chr4:165956403 G/A cg10852876 chr4:165953100 TRIM60 -0.47 -5.43 -0.32 1.28e-7 Obesity-related traits; CESC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg07414643 chr4:187882934 NA 0.53 7.36 0.41 2.33e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs4474465 0.646 rs10793334 chr11:78278792 C/T cg27205649 chr11:78285834 NARS2 -0.51 -6.93 -0.39 3.21e-11 Alzheimer's disease (survival time); CESC trans rs9325144 0.647 rs12830095 chr12:38864199 C/T cg10679878 chr6:156759499 NA -0.33 -6.0 -0.35 6.61e-9 Morning vs. evening chronotype; CESC cis rs881375 0.631 rs2416808 chr9:123706283 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 6.37 0.36 8.22e-10 Rheumatoid arthritis; CESC trans rs1973993 0.967 rs10875017 chr1:96949526 C/T cg10631902 chr5:14652156 NA 0.53 7.39 0.41 1.87e-12 Weight; CESC cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg06636001 chr8:8085503 FLJ10661 0.47 5.88 0.34 1.26e-8 Parkinson's disease; CESC cis rs4835473 0.932 rs35002497 chr4:144694105 A/G cg25736465 chr4:144833511 NA -0.33 -5.15 -0.3 5e-7 Immature fraction of reticulocytes; CESC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs7116495 1.000 rs1939245 chr11:71742532 C/T cg10381502 chr11:71823885 C11orf51 -0.65 -5.29 -0.31 2.62e-7 Severe influenza A (H1N1) infection; CESC cis rs11166629 0.679 rs1583969 chr8:135661484 C/T cg27224718 chr8:135614730 ZFAT 0.43 5.13 0.3 5.54e-7 Smoking quantity; CESC cis rs9790314 1.000 rs4273380 chr3:160950314 A/G cg03342759 chr3:160939853 NMD3 -0.47 -6.22 -0.36 1.91e-9 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09327694 chr16:89751805 CDK10 -0.54 -6.61 -0.38 2.11e-10 Gut microbiome composition (summer); CESC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg19592336 chr6:28129416 ZNF389 0.55 5.97 0.34 7.62e-9 Depression; CESC cis rs636291 0.517 rs673254 chr1:10550352 C/T cg20482658 chr1:10539492 PEX14 -0.27 -5.63 -0.33 4.53e-8 Prostate cancer; CESC cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.4 0.32 1.46e-7 Colonoscopy-negative controls vs population controls; CESC cis rs909674 0.690 rs1972280 chr22:39831986 T/A cg05872129 chr22:39784769 NA -0.77 -10.46 -0.54 1.13e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs60843830 1.000 rs17713396 chr2:227201 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.78 9.71 0.51 2.85e-19 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs3015497 0.537 rs2934663 chr14:51155995 T/C cg26011998 chr14:51135199 SAV1 -0.54 -6.1 -0.35 3.84e-9 Mean platelet volume; CESC cis rs9894429 0.816 rs9747093 chr17:79584280 G/A cg13777783 chr17:79615861 NA -0.33 -5.59 -0.33 5.5e-8 Eye color traits; CESC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg26335602 chr6:28129616 ZNF389 0.5 6.53 0.37 3.25e-10 Depression; CESC trans rs208515 0.525 rs12214310 chr6:66666308 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 10.74 0.55 1.42e-22 Exhaled nitric oxide levels; CESC cis rs9911578 1.000 rs12602346 chr17:56901713 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis); CESC cis rs2730245 0.527 rs1188971 chr7:158664463 G/T cg24397884 chr7:158709396 WDR60 0.83 8.53 0.46 1.15e-15 Height; CESC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg12463550 chr7:65579703 CRCP 0.49 6.21 0.36 2.07e-9 Aortic root size; CESC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg06873352 chr17:61820015 STRADA 0.73 12.98 0.62 3.9e-30 Prudent dietary pattern; CESC cis rs9902453 0.845 rs2617865 chr17:28049804 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -8.43 -0.46 2.26e-15 Coffee consumption (cups per day); CESC cis rs216205 0.547 rs2641431 chr17:2030507 C/G cg16513277 chr17:2031491 SMG6 -0.61 -6.79 -0.39 7.17e-11 Mitral valve prolapse; CESC cis rs4919044 0.808 rs2486687 chr10:94778283 T/C cg26979504 chr10:94451518 HHEX -0.47 -5.15 -0.3 5.16e-7 Coronary artery disease; CESC cis rs4654899 0.895 rs7515590 chr1:21216664 T/C cg05370193 chr1:21551575 ECE1 -0.36 -5.15 -0.3 5.17e-7 Superior frontal gyrus grey matter volume; CESC cis rs2708240 1.000 rs2247137 chr7:147581002 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.55 -0.32 7.07e-8 QT interval (drug interaction); CESC cis rs116095464 0.558 rs7356535 chr5:284117 G/T cg22857025 chr5:266934 NA -1.32 -14.16 -0.66 2.9e-34 Breast cancer; CESC cis rs12681288 0.578 rs10503154 chr8:969343 C/G cg04851639 chr8:1020857 NA -0.31 -5.93 -0.34 9.26e-9 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14094333 chr4:38666051 KLF3;FLJ13197 -0.46 -6.76 -0.38 8.69e-11 Fibrinogen levels; CESC cis rs854765 0.552 rs11078407 chr17:17841083 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.52 7.01 0.4 2.02e-11 Total body bone mineral density; CESC cis rs4862307 0.514 rs7696176 chr4:185014390 A/G cg06737308 chr4:185021514 ENPP6 0.67 10.78 0.55 1.08e-22 Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg24110177 chr3:50126178 RBM5 0.56 7.76 0.43 1.89e-13 Body mass index; CESC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg21138405 chr5:131827807 IRF1 0.38 5.77 0.33 2.26e-8 Breast cancer;Mosquito bite size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07628558 chr20:56964831 VAPB -0.45 -6.38 -0.36 8.05e-10 Gambling; CESC cis rs1707322 0.721 rs12037803 chr1:46156492 A/G cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg00033643 chr7:134001901 SLC35B4 0.4 5.17 0.3 4.63e-7 Mean platelet volume; CESC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg11663144 chr21:46675770 NA -0.48 -6.52 -0.37 3.49e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1865721 0.771 rs6566092 chr18:73136496 C/T cg26385618 chr18:73139727 C18orf62 -0.51 -8.36 -0.46 3.47e-15 Intelligence; CESC cis rs7103648 0.545 rs6485795 chr11:47929846 G/A cg20307385 chr11:47447363 PSMC3 0.76 10.98 0.56 2.36e-23 Diastolic blood pressure;Systolic blood pressure; CESC cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg12698349 chr2:225449008 CUL3 0.62 8.39 0.46 3.02e-15 IgE levels in asthmatics (D.p. specific); CESC cis rs911555 0.755 rs2273702 chr14:103918182 C/G cg24130564 chr14:104152367 KLC1 0.54 7.3 0.41 3.37e-12 Intelligence (multi-trait analysis); CESC cis rs10887741 0.646 rs11202501 chr10:89437208 C/T cg13926569 chr10:89418898 PAPSS2 0.47 7.15 0.4 8.25e-12 Exercise (leisure time); CESC cis rs3768617 0.528 rs6686682 chr1:183080539 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.96 0.65 1.41e-33 Fuchs's corneal dystrophy; CESC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg24733560 chr20:60626293 TAF4 0.46 6.68 0.38 1.38e-10 Body mass index; CESC cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7267005 0.661 rs2425099 chr20:34309643 T/C cg17201900 chr20:34330562 RBM39 0.93 5.07 0.3 7.47e-7 Response to paliperidone in schizophrenia (Multivariate); CESC cis rs916888 0.821 rs199525 chr17:44847834 T/G cg15921436 chr17:44337874 NA 0.74 7.89 0.44 8.12e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg06108461 chr20:60628389 TAF4 -0.92 -14.36 -0.66 5.41e-35 Body mass index; CESC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg22920501 chr2:26401640 FAM59B -0.86 -10.06 -0.53 2.22e-20 Gut microbiome composition (summer); CESC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg26732615 chr19:19648335 CILP2;YJEFN3 -0.43 -5.38 -0.31 1.64e-7 Tonsillectomy; CESC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg14703610 chr5:56206110 C5orf35 0.42 5.09 0.3 6.87e-7 Coronary artery disease; CESC cis rs2573652 0.722 rs12898366 chr15:100543067 C/T cg00587665 chr15:100533223 ADAMTS17 -0.43 -7.1 -0.4 1.11e-11 Height; CESC cis rs3015497 0.789 rs3015496 chr14:51114051 T/C cg09863266 chr14:51125203 SAV1 -0.34 -5.3 -0.31 2.48e-7 Mean platelet volume; CESC cis rs12822507 0.868 rs34051318 chr12:12798338 T/C cg04607235 chr12:12878440 APOLD1 -0.5 -6.42 -0.37 6.25e-10 Systemic lupus erythematosus; CESC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg17971929 chr21:40555470 PSMG1 -0.86 -12.23 -0.6 1.45e-27 Cognitive function; CESC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg17143192 chr8:8559678 CLDN23 0.43 5.19 0.3 4.25e-7 Mood instability; CESC cis rs12541635 0.966 rs6469031 chr8:107048095 T/C cg10147462 chr8:107024639 NA 0.42 5.97 0.34 7.51e-9 Age of smoking initiation; CESC cis rs1865721 1.000 rs17283454 chr18:73186619 G/A cg26385618 chr18:73139727 C18orf62 -0.51 -7.6 -0.42 5.14e-13 Intelligence; CESC cis rs1023500 0.507 rs6002600 chr22:42488906 G/A cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26737766 chr1:24127303 GALE -0.65 -7.75 -0.43 1.99e-13 Gut microbiome composition (summer); CESC cis rs4764124 0.571 rs11830399 chr12:14956932 G/C cg19759883 chr12:14956454 WBP11;C12orf60 0.58 8.58 0.47 8.3e-16 Pubertal anthropometrics; CESC cis rs9291683 0.525 rs12506455 chr4:10031569 T/A cg11266682 chr4:10021025 SLC2A9 0.71 14.26 0.66 1.27e-34 Bone mineral density; CESC cis rs7107174 0.681 rs4340079 chr11:78007920 C/T cg02023728 chr11:77925099 USP35 0.47 6.55 0.37 3.02e-10 Testicular germ cell tumor; CESC cis rs6998277 1.000 rs4734648 chr8:103635994 G/A cg10187029 chr8:103597600 NA 0.57 6.54 0.37 3.19e-10 Migraine; CESC cis rs1580019 0.587 rs6972365 chr7:32548931 T/A cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.39 0.37 7.42e-10 Cognitive ability; CESC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg23281280 chr6:28129359 ZNF389 0.59 8.13 0.45 1.68e-14 Depression; CESC cis rs7872515 1.000 rs7852067 chr9:94815594 A/G cg01248375 chr9:94877805 SPTLC1 0.57 5.77 0.33 2.21e-8 Bipolar disorder and schizophrenia; CESC trans rs17685 0.672 rs6465011 chr7:75811297 T/C cg19862616 chr7:65841803 NCRNA00174 0.82 11.63 0.58 1.54e-25 Coffee consumption;Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15057823 chr6:42981704 MEA1;KLHDC3 0.65 7.05 0.4 1.59e-11 Gut microbiome composition (summer); CESC cis rs631288 0.793 rs11239952 chr1:146715204 A/G cg25205988 chr1:146714368 CHD1L 1.05 8.82 0.48 1.55e-16 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs6460942 1.000 rs77494477 chr7:12315302 A/T cg06484146 chr7:12443880 VWDE -0.81 -8.78 -0.47 2.13e-16 Coronary artery disease; CESC cis rs35110281 0.667 rs9941787 chr21:45116042 A/G cg21573476 chr21:45109991 RRP1B -0.57 -8.09 -0.45 2.1e-14 Mean corpuscular volume; CESC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.56 -0.32 6.62e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs258892 0.895 rs34646 chr5:72113061 C/T cg21869765 chr5:72125136 TNPO1 -0.44 -5.65 -0.33 4.05e-8 Small cell lung carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27037990 chr4:184427250 ING2 0.56 6.21 0.36 2.04e-9 Gut microbiome composition (summer); CESC trans rs2235573 0.625 rs1883471 chr22:38417510 T/C cg19894588 chr14:64061835 NA 0.49 6.32 0.36 1.08e-9 Glioblastoma;Glioma; CESC cis rs595982 0.559 rs4802516 chr19:49366170 T/C cg15549821 chr19:49342101 PLEKHA4 -0.7 -7.94 -0.44 5.71e-14 Red cell distribution width; CESC cis rs870825 0.616 rs877276 chr4:185621249 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs3733585 0.746 rs4318650 chr4:10016868 T/C cg00071950 chr4:10020882 SLC2A9 0.82 13.82 0.65 4.37e-33 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1018836 0.798 rs28568272 chr8:91652958 A/G cg16814680 chr8:91681699 NA -0.9 -13.92 -0.65 1.97e-33 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs7246657 0.943 rs7259968 chr19:37811854 T/C cg24637308 chr11:6592297 DNHD1 0.52 6.07 0.35 4.35e-9 Coronary artery calcification; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06452419 chr17:55938940 NA -0.55 -6.49 -0.37 4.27e-10 Gut microbiome composition (summer); CESC cis rs9583531 0.600 rs3809344 chr13:111358705 G/A cg15841412 chr13:111365552 ING1 0.52 6.74 0.38 1.01e-10 Coronary artery disease; CESC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg24250549 chr1:154909240 PMVK 0.71 10.61 0.55 3.83e-22 Prostate cancer; CESC cis rs3733585 0.699 rs6449158 chr4:9960459 T/C cg02734326 chr4:10020555 SLC2A9 -0.44 -6.15 -0.35 2.85e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9768139 0.903 rs10262701 chr7:158114591 G/A cg06219351 chr7:158114137 PTPRN2 0.53 8.34 0.46 3.99e-15 Calcium levels; CESC cis rs9303401 0.659 rs17222621 chr17:56695923 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.04 13.0 0.62 3.27e-30 Cognitive test performance; CESC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg06713675 chr4:122721982 EXOSC9 -0.51 -6.95 -0.39 2.8e-11 Type 2 diabetes; CESC cis rs7843479 0.601 rs11135764 chr8:21814004 A/G cg17168535 chr8:21777572 XPO7 0.73 11.77 0.59 5.33e-26 Mean corpuscular volume; CESC cis rs62103177 1.000 rs62103177 chr18:77624479 G/A cg12964065 chr18:77638022 KCNG2 0.56 5.44 0.32 1.19e-7 Opioid sensitivity; CESC cis rs2120019 0.938 rs35911108 chr15:75322179 G/A cg09165964 chr15:75287851 SCAMP5 -0.8 -9.94 -0.52 5.37e-20 Blood trace element (Zn levels); CESC cis rs4689388 0.926 rs1801214 chr4:6303022 C/T cg25554036 chr4:6271136 WFS1 0.55 9.19 0.49 1.16e-17 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9291683 0.538 rs11727199 chr4:10036190 C/T cg02734326 chr4:10020555 SLC2A9 0.47 6.51 0.37 3.75e-10 Bone mineral density; CESC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg05343316 chr1:45956843 TESK2 -0.48 -6.08 -0.35 4.21e-9 High light scatter reticulocyte count; CESC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg00815214 chr21:47717953 NA -0.45 -6.17 -0.35 2.53e-9 Testicular germ cell tumor; CESC cis rs10883723 0.810 rs7090276 chr10:104281239 G/T cg22532475 chr10:104410764 TRIM8 -0.33 -5.67 -0.33 3.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg22823121 chr1:150693482 HORMAD1 0.47 6.96 0.39 2.6e-11 Tonsillectomy; CESC cis rs2439831 1.000 rs2439831 chr15:43784475 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.85 12.03 0.59 7.15e-27 Lung cancer in ever smokers; CESC cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg16240275 chr20:61666158 NCRNA00029 -0.43 -7.35 -0.41 2.41e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs2415984 0.579 rs1494097 chr14:46960552 T/C cg14871534 chr14:47121158 RPL10L 0.35 5.32 0.31 2.17e-7 Number of children ever born; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23709674 chr6:36410515 PXT1;KCTD20 0.59 6.51 0.37 3.69e-10 Gut microbiome composition (summer); CESC cis rs11229555 0.874 rs11229505 chr11:58274155 T/C cg15696309 chr11:58395628 NA -0.41 -5.03 -0.3 8.87e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs7301826 1.000 rs4759793 chr12:131297238 A/G cg11011512 chr12:131303247 STX2 0.4 5.09 0.3 6.83e-7 Plasma plasminogen activator levels; CESC cis rs4925386 0.840 rs6143034 chr20:60920545 T/C cg22633769 chr20:60982531 CABLES2 0.53 5.54 0.32 7.16e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs1832871 0.672 rs62437361 chr6:158728759 C/T cg07165851 chr6:158734300 TULP4 0.6 6.65 0.38 1.68e-10 Height; CESC cis rs4727963 0.792 rs10247666 chr7:122717198 A/G cg03640110 chr7:122635026 TAS2R16 -0.4 -6.47 -0.37 4.71e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs6500602 0.610 rs1659499 chr16:4595269 G/A cg08645402 chr16:4508243 NA -0.46 -7.35 -0.41 2.53e-12 Schizophrenia; CESC cis rs7772486 0.846 rs2748496 chr6:146321829 T/A cg05347473 chr6:146136440 FBXO30 0.51 6.73 0.38 1.03e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06529439 chr2:88991002 RPIA 0.59 6.85 0.39 5.19e-11 Gut microbiome composition (summer); CESC cis rs9868809 0.772 rs9877501 chr3:48718390 C/G cg03060546 chr3:49711283 APEH -0.67 -5.77 -0.33 2.19e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs854765 0.551 rs6502626 chr17:17849450 C/T cg16928487 chr17:17741425 SREBF1 -0.53 -8.75 -0.47 2.54e-16 Total body bone mineral density; CESC cis rs477692 0.905 rs508360 chr10:131424969 A/G cg26102564 chr10:131424627 MGMT 0.36 5.39 0.31 1.52e-7 Response to temozolomide; CESC cis rs1538970 1.000 rs1417578 chr1:45850590 A/G cg05343316 chr1:45956843 TESK2 0.77 10.92 0.56 3.56e-23 Platelet count; CESC cis rs12464559 0.649 rs4664496 chr2:152522556 T/C cg01189475 chr2:152685088 ARL5A -0.57 -5.12 -0.3 5.91e-7 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs6088580 0.634 rs6119497 chr20:33012529 T/A cg08999081 chr20:33150536 PIGU 0.65 11.43 0.57 7.54e-25 Glomerular filtration rate (creatinine); CESC cis rs6693567 0.565 rs1694379 chr1:150292417 C/A cg09579323 chr1:150459698 TARS2 0.49 6.22 0.36 1.96e-9 Migraine; CESC cis rs1707322 0.752 rs3811435 chr1:46125790 C/A cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9488822 0.676 rs873879 chr6:116391259 A/G cg18764771 chr6:116381957 FRK 0.24 6.02 0.35 5.79e-9 Cholesterol, total;LDL cholesterol; CESC trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg15556689 chr8:8085844 FLJ10661 -0.52 -6.39 -0.37 7.38e-10 Neuroticism; CESC cis rs3815700 1.000 rs8101356 chr19:33093402 C/T cg02997394 chr19:33096574 ANKRD27 0.73 7.3 0.41 3.26e-12 Eosinophilic esophagitis; CESC cis rs533581 0.866 rs865102 chr16:88969969 A/G cg16701003 chr16:89028210 CBFA2T3 0.47 6.89 0.39 4.08e-11 Social autistic-like traits; CESC cis rs847577 1.000 rs847577 chr7:97694858 T/A cg21770322 chr7:97807741 LMTK2 -0.65 -10.74 -0.55 1.45e-22 Breast cancer; CESC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg27478167 chr7:817139 HEATR2 -0.51 -5.4 -0.31 1.51e-7 Cerebrospinal P-tau181p levels; CESC cis rs12464559 0.522 rs10180065 chr2:152619007 A/G cg01189475 chr2:152685088 ARL5A -0.77 -7.32 -0.41 2.88e-12 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs75804782 0.641 rs112066551 chr2:239362486 G/A cg18131467 chr2:239335373 ASB1 -0.7 -5.56 -0.32 6.56e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs2952156 0.920 rs11078919 chr17:37835755 T/C cg00129232 chr17:37814104 STARD3 -0.76 -11.04 -0.56 1.44e-23 Asthma; CESC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg22143856 chr6:28129313 ZNF389 0.49 6.21 0.36 2.02e-9 Depression; CESC cis rs4481887 0.741 rs6421453 chr1:248533285 A/G cg26353448 chr1:248524236 OR2T4 -0.38 -5.35 -0.31 1.9e-7 Common traits (Other); CESC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 5.36 0.31 1.86e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7116495 0.609 rs1894004 chr11:71759817 G/A cg10381502 chr11:71823885 C11orf51 -1.16 -7.39 -0.41 1.9e-12 Severe influenza A (H1N1) infection; CESC cis rs1707322 0.752 rs4586014 chr1:46150443 A/G cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1552244 0.748 rs9862221 chr3:10059658 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.77 -9.47 -0.5 1.63e-18 Alzheimer's disease; CESC cis rs9487051 0.676 rs9398196 chr6:109601554 A/G cg21918786 chr6:109611834 NA -0.39 -5.74 -0.33 2.56e-8 Reticulocyte fraction of red cells; CESC cis rs2354432 0.607 rs7511989 chr1:146720160 A/G cg25205988 chr1:146714368 CHD1L -1.01 -8.47 -0.46 1.68e-15 Mitochondrial DNA levels; CESC cis rs1609391 0.543 rs2117009 chr3:136633571 A/T cg15507776 chr3:136538369 TMEM22 -0.83 -12.27 -0.6 1.02e-27 Neuroticism; CESC cis rs6088580 0.505 rs6142219 chr20:33256345 G/A cg24642439 chr20:33292090 TP53INP2 -0.47 -5.53 -0.32 7.81e-8 Glomerular filtration rate (creatinine); CESC cis rs1008375 0.966 rs1860599 chr4:17638900 T/C cg16339924 chr4:17578868 LAP3 0.56 7.13 0.4 9.83e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs55883249 1.000 rs10495573 chr2:9712160 T/G cg23886495 chr2:9695866 ADAM17 0.59 5.52 0.32 7.91e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25733915 chr17:40829168 PLEKHH3 0.48 6.28 0.36 1.34e-9 Systemic lupus erythematosus; CESC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg14558114 chr2:88469736 THNSL2 -0.53 -7.73 -0.43 2.31e-13 Response to metformin (IC50); CESC cis rs6500602 0.702 rs11076835 chr16:4549618 G/A cg08645402 chr16:4508243 NA 0.53 8.64 0.47 5.21e-16 Schizophrenia; CESC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg11764359 chr7:65958608 NA 0.94 14.96 0.68 4.3e-37 Aortic root size; CESC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg25072359 chr17:41440525 NA 0.45 6.7 0.38 1.28e-10 Menopause (age at onset); CESC trans rs11088226 0.645 rs11702343 chr21:33937888 C/A cg09050820 chr6:167586206 TCP10L2 0.8 7.55 0.42 7.17e-13 Gastritis; CESC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg11494091 chr17:61959527 GH2 0.72 12.13 0.6 3.12e-27 Prudent dietary pattern; CESC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg10596483 chr8:143751796 JRK -0.45 -5.51 -0.32 8.54e-8 Urinary tract infection frequency; CESC cis rs2795502 1.000 rs2795503 chr10:43347224 T/A cg20628663 chr10:43360327 NA -0.61 -7.22 -0.41 5.62e-12 Blood protein levels; CESC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.42 -5.28 -0.31 2.67e-7 Menarche (age at onset); CESC trans rs7837860 0.588 rs71526930 chr8:89281625 T/A cg04391754 chr17:18022714 MYO15A 0.52 6.12 0.35 3.41e-9 Autism spectrum disorder or schizophrenia; CESC cis rs818427 0.613 rs818797 chr5:112219140 G/A cg07820702 chr5:112228657 REEP5 -0.4 -5.12 -0.3 5.75e-7 Total body bone mineral density; CESC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg08470875 chr2:26401718 FAM59B -0.48 -5.26 -0.31 3e-7 Gut microbiome composition (summer); CESC cis rs5758659 0.652 rs133330 chr22:42409456 G/A cg15557168 chr22:42548783 NA -0.42 -6.27 -0.36 1.48e-9 Cognitive function; CESC cis rs12200560 0.505 rs2015196 chr6:97075331 G/C cg06623918 chr6:96969491 KIAA0776 0.5 6.49 0.37 4.13e-10 Coronary heart disease; CESC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.73 0.43 2.22e-13 Prudent dietary pattern; CESC cis rs9640161 0.750 rs11769348 chr7:150026753 C/T cg21361702 chr7:150065534 REPIN1 -0.48 -5.3 -0.31 2.42e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg07507251 chr3:52567010 NT5DC2 0.32 5.52 0.32 8.04e-8 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13699934 chr9:93956018 NA -0.44 -6.11 -0.35 3.55e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4474465 0.790 rs10793331 chr11:78270000 C/T cg27205649 chr11:78285834 NARS2 0.47 6.01 0.35 6.1e-9 Alzheimer's disease (survival time); CESC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg02569458 chr12:86230093 RASSF9 0.5 7.51 0.42 9.29e-13 Major depressive disorder; CESC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg20151795 chr6:28129481 ZNF389 0.46 5.83 0.34 1.65e-8 Parkinson's disease; CESC trans rs1437396 0.610 rs7572492 chr2:55640033 A/G cg07921503 chr7:2445843 CHST12 0.25 6.11 0.35 3.53e-9 Alcohol dependence; CESC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg12463550 chr7:65579703 CRCP 0.57 7.2 0.4 6.12e-12 Aortic root size; CESC cis rs8114671 0.551 rs4911162 chr20:33411425 G/C cg07148914 chr20:33460835 GGT7 0.42 5.32 0.31 2.25e-7 Height; CESC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.36 5.14 0.3 5.29e-7 Electroencephalogram traits; CESC cis rs2302190 0.882 rs3803751 chr17:56650356 A/G cg25885038 chr17:56607967 SEPT4 -0.41 -5.52 -0.32 7.89e-8 Vitamin D levels; CESC cis rs453301 0.682 rs2929308 chr8:9084121 T/A cg17143192 chr8:8559678 CLDN23 -0.45 -5.61 -0.33 5.04e-8 Joint mobility (Beighton score); CESC cis rs2742234 0.955 rs2503849 chr10:43672776 G/A cg15436174 chr10:43711423 RASGEF1A -0.42 -5.25 -0.31 3.09e-7 Hirschsprung disease; CESC cis rs4975709 0.758 rs4975756 chr5:1882443 T/C cg15595755 chr5:1867978 NA 0.49 7.47 0.42 1.14e-12 Cardiovascular disease risk factors; CESC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg18099408 chr3:52552593 STAB1 0.32 5.2 0.3 4.07e-7 Bipolar disorder; CESC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg11987759 chr7:65425863 GUSB -0.46 -6.19 -0.36 2.29e-9 Calcium levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01708693 chr16:2314216 RNPS1 0.52 7.05 0.4 1.55e-11 Fibrinogen levels; CESC cis rs12711979 0.740 rs6711963 chr2:3820915 A/T cg17052675 chr2:3827356 NA -0.41 -6.47 -0.37 4.74e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs2933343 0.700 rs1683787 chr3:128627021 C/T cg11901034 chr3:128598214 ACAD9 0.35 5.24 0.31 3.36e-7 IgG glycosylation; CESC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg04369109 chr6:150039330 LATS1 -0.44 -6.06 -0.35 4.73e-9 Lung cancer; CESC cis rs6964587 1.000 rs12540055 chr7:91707921 A/G cg17063962 chr7:91808500 NA 0.53 7.07 0.4 1.41e-11 Breast cancer; CESC cis rs34779708 0.966 rs35777088 chr10:35409048 T/C cg03585969 chr10:35415529 CREM 0.77 10.1 0.53 1.71e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg26338869 chr17:61819248 STRADA 0.74 9.88 0.52 8.67e-20 Prudent dietary pattern; CESC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg04414720 chr1:150670196 GOLPH3L 0.63 9.04 0.49 3.47e-17 Tonsillectomy; CESC cis rs1055129 0.560 rs2666003 chr17:73942976 G/A cg02678768 chr17:74002944 EVPL 0.38 5.25 0.31 3.07e-7 White matter hyperintensity burden; CESC cis rs9486719 0.895 rs4486019 chr6:96883814 T/C cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg22920501 chr2:26401640 FAM59B 0.91 10.38 0.54 2.08e-21 Gut microbiome composition (summer); CESC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg01988459 chr11:68622903 NA 0.42 5.77 0.33 2.23e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg00684032 chr4:1343700 KIAA1530 0.35 5.43 0.32 1.3e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05228244 chr10:1102351 WDR37 0.53 6.24 0.36 1.68e-9 Gut microbiome composition (summer); CESC cis rs7786877 0.761 rs11772705 chr7:100298904 T/C cg16850897 chr7:100343110 ZAN -0.68 -8.65 -0.47 4.95e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs17599629 0.502 rs2055975 chr1:150618632 G/T cg04414720 chr1:150670196 GOLPH3L -0.5 -6.5 -0.37 4.02e-10 Prostate cancer; CESC cis rs66573146 1.000 rs55833486 chr4:6978729 C/A cg00086871 chr4:6988644 TBC1D14 1.21 7.89 0.44 7.91e-14 Granulocyte percentage of myeloid white cells; CESC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg26338869 chr17:61819248 STRADA 0.72 9.53 0.51 1.05e-18 Prudent dietary pattern; CESC cis rs12476592 0.543 rs10170988 chr2:63650582 T/C cg17519650 chr2:63277830 OTX1 -0.46 -5.21 -0.3 3.83e-7 Childhood ear infection; CESC cis rs12478296 1.000 rs56102931 chr2:243039936 A/G cg06360820 chr2:242988706 NA -0.66 -7.52 -0.42 8.51e-13 Obesity-related traits; CESC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg00769240 chr8:12517080 NA -0.44 -6.02 -0.35 5.7e-9 Blood pressure (smoking interaction); CESC cis rs1707322 0.721 rs10890344 chr1:46166090 C/T cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9462846 0.919 rs12202901 chr6:42828550 A/T cg02353165 chr6:42928485 GNMT 0.46 5.4 0.31 1.5e-7 Blood protein levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06861343 chr3:52739491 GLT8D1;SPCS1 -0.46 -6.36 -0.36 8.87e-10 Asthma; CESC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg12419862 chr22:24373484 LOC391322 0.7 9.79 0.52 1.5700000000000001e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.84 0.34 1.49e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs13191362 0.507 rs2849534 chr6:163144657 T/A cg06582575 chr6:163149167 PACRG;PARK2 -0.5 -5.92 -0.34 1.01e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg00149659 chr3:10157352 C3orf10 -0.69 -8.76 -0.47 2.42e-16 Alzheimer's disease; CESC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.53 0.37 3.33e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25889035 chr2:236826311 AGAP1 -0.56 -6.48 -0.37 4.53e-10 Gut microbiome composition (summer); CESC cis rs2276314 0.857 rs4799409 chr18:33592602 C/T cg19628046 chr18:33552617 C18orf21 0.51 5.76 0.33 2.3e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg05368731 chr17:41323189 NBR1 0.8 11.13 0.56 7.38e-24 Menopause (age at onset); CESC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg20999797 chr1:1681921 NA 0.26 5.13 0.3 5.59e-7 Body mass index; CESC cis rs9430161 0.579 rs9659356 chr1:11034817 A/G cg27631724 chr1:11040367 C1orf127 0.36 5.95 0.34 8.56e-9 Ewing sarcoma; CESC cis rs7714584 0.793 rs35707106 chr5:150225377 G/A cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs9291683 0.588 rs3733586 chr4:9997534 C/T cg00071950 chr4:10020882 SLC2A9 0.85 15.67 0.69 1.27e-39 Bone mineral density; CESC cis rs208520 0.690 rs12213581 chr6:66735818 T/C cg07460842 chr6:66804631 NA 0.96 12.81 0.62 1.47e-29 Exhaled nitric oxide output; CESC cis rs11098499 0.863 rs2306457 chr4:120472839 T/A cg09307838 chr4:120376055 NA 0.9 12.43 0.61 3.08e-28 Corneal astigmatism; CESC cis rs28673728 0.897 rs28391281 chr1:38408974 T/C cg17077180 chr1:38461687 NA 0.46 6.9 0.39 3.83e-11 Red cell distribution width; CESC cis rs6762 0.719 rs7936806 chr11:839186 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.66 -8.23 -0.45 8.83e-15 Mean platelet volume; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg18404041 chr3:52824283 ITIH1 -0.35 -6.35 -0.36 9.25e-10 Bipolar disorder; CESC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg24531977 chr5:56204891 C5orf35 -0.87 -10.87 -0.56 5.43e-23 Initial pursuit acceleration; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17146150 chr15:56657437 TEX9 0.47 6.05 0.35 4.9e-9 Systemic lupus erythematosus; CESC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg04369109 chr6:150039330 LATS1 -0.4 -5.46 -0.32 1.08e-7 Lung cancer; CESC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg05313129 chr8:58192883 C8orf71 -0.49 -5.28 -0.31 2.72e-7 Developmental language disorder (linguistic errors); CESC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg11663144 chr21:46675770 NA -0.6 -9.35 -0.5 3.74e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs72945132 0.882 rs12282678 chr11:70152457 G/A cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs7586879 0.593 rs11689546 chr2:25130451 A/G cg01884057 chr2:25150051 NA 0.37 7.08 0.4 1.26e-11 Body mass index; CESC cis rs763121 0.853 rs138705 chr22:39133803 C/T cg06022373 chr22:39101656 GTPBP1 0.87 13.92 0.65 2.02e-33 Menopause (age at onset); CESC cis rs4595586 0.525 rs7970652 chr12:39374873 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg10845886 chr2:3471009 TTC15 -0.68 -9.33 -0.5 4.29e-18 Neurofibrillary tangles; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23055396 chr11:62538850 TAF6L -0.45 -6.66 -0.38 1.55e-10 Gambling; CESC cis rs7208859 0.673 rs9907197 chr17:29018263 C/T cg14008862 chr17:28927542 LRRC37B2 0.59 5.18 0.3 4.49e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11696501 0.739 rs6073815 chr20:44234615 A/T cg11783356 chr20:44313418 WFDC10B -0.35 -5.31 -0.31 2.32e-7 Brain structure; CESC cis rs7927771 0.524 rs7118747 chr11:47889545 C/T cg20307385 chr11:47447363 PSMC3 -0.58 -8.1 -0.45 2.09e-14 Subjective well-being; CESC cis rs897080 0.515 rs1067331 chr2:44627626 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.82 0.34 1.67e-8 Height; CESC cis rs2288073 0.801 rs72797831 chr2:24366829 G/A cg06627628 chr2:24431161 ITSN2 -0.71 -8.82 -0.48 1.53e-16 Venous thromboembolism (SNP x SNP interaction); CESC cis rs258892 0.947 rs266444 chr5:72181404 C/T cg21869765 chr5:72125136 TNPO1 0.47 5.96 0.34 8.09e-9 Small cell lung carcinoma; CESC cis rs10504229 1.000 rs58608483 chr8:58195269 T/G cg22535103 chr8:58192502 C8orf71 -0.89 -11.11 -0.56 8.23e-24 Developmental language disorder (linguistic errors); CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg03188948 chr7:1209495 NA 0.6 6.83 0.39 5.73e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09377915 chr6:56295593 NA -0.43 -6.2 -0.36 2.2e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4315565 0.764 rs4467309 chr2:69286921 C/T cg12800200 chr2:69260302 ANTXR1 -0.42 -6.08 -0.35 4.23e-9 Height; CESC cis rs9287719 0.967 rs10195802 chr2:10754532 C/T cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs6460942 0.597 rs17545416 chr7:12525944 A/T cg20607287 chr7:12443886 VWDE -0.71 -7.67 -0.43 3.19e-13 Coronary artery disease; CESC trans rs9467711 0.606 rs9348726 chr6:26605206 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -7.17 -0.4 7.32e-12 Autism spectrum disorder or schizophrenia; CESC cis rs597539 0.690 rs11228383 chr11:68623228 T/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.35 0.5 3.73e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1670533 1.000 rs7669399 chr4:1058478 T/G cg27284194 chr4:1044797 NA 0.47 5.99 0.35 6.72e-9 Recombination rate (females); CESC cis rs2228479 0.702 rs78331410 chr16:89917775 C/T cg04013166 chr16:89971882 TCF25 0.74 5.83 0.34 1.59e-8 Skin colour saturation; CESC cis rs9487051 1.000 rs7748918 chr6:109613564 A/G cg01475377 chr6:109611718 NA -0.42 -6.35 -0.36 9.13e-10 Reticulocyte fraction of red cells; CESC cis rs17376456 0.877 rs9314101 chr5:93461593 A/T cg21475434 chr5:93447410 FAM172A 0.82 7.56 0.42 6.81e-13 Diabetic retinopathy; CESC cis rs2742234 0.541 rs1317214 chr10:43733531 C/G cg07801480 chr10:43725741 RASGEF1A -0.41 -5.3 -0.31 2.47e-7 Hirschsprung disease; CESC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg18337363 chr3:52569053 NT5DC2 0.29 5.36 0.31 1.8e-7 Bipolar disorder; CESC cis rs12325245 0.536 rs34129245 chr16:58588191 A/G cg05725404 chr16:58534157 NDRG4 -0.61 -5.24 -0.31 3.21e-7 Schizophrenia; CESC trans rs1814175 0.588 rs10839463 chr11:49971643 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs6582630 0.555 rs10880612 chr12:38509427 A/G cg26384229 chr12:38710491 ALG10B 0.7 10.5 0.54 8.9e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.08 10.67 0.55 2.41e-22 Platelet count; CESC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.52 -0.37 3.51e-10 Life satisfaction; CESC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg23172400 chr8:95962367 TP53INP1 -0.36 -6.6 -0.38 2.21e-10 Type 2 diabetes; CESC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg22920501 chr2:26401640 FAM59B -0.85 -10.05 -0.53 2.42e-20 Gut microbiome composition (summer); CESC cis rs965469 1.000 rs6051810 chr20:3355384 A/G cg25506879 chr20:3388711 C20orf194 -0.57 -6.12 -0.35 3.41e-9 IFN-related cytopenia; CESC cis rs9905704 0.647 rs12943705 chr17:57097047 T/C cg12560992 chr17:57184187 TRIM37 -0.61 -7.5 -0.42 9.51e-13 Testicular germ cell tumor; CESC cis rs61332075 0.518 rs72993031 chr2:239380028 A/G cg18131467 chr2:239335373 ASB1 -0.74 -6.11 -0.35 3.58e-9 Lung function (FEV1/FVC); CESC cis rs9457247 1.000 rs2013815 chr6:167373812 T/A cg25258033 chr6:167368657 RNASET2 -0.41 -6.21 -0.36 2.09e-9 Crohn's disease; CESC cis rs559928 0.606 rs78038516 chr11:63978067 C/G cg18225595 chr11:63971243 STIP1 0.64 5.96 0.34 8.23e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs17253792 0.822 rs75560658 chr14:56079896 C/T cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg12463550 chr7:65579703 CRCP -0.46 -5.94 -0.34 8.81e-9 Aortic root size; CESC cis rs11718455 0.960 rs34241796 chr3:44000394 A/T cg08738300 chr3:44038990 NA 0.46 6.22 0.36 1.96e-9 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24589334 chr7:1097720 C7orf50;GPR146 0.44 6.07 0.35 4.52e-9 Fibrinogen levels; CESC cis rs698833 1.000 rs1067352 chr2:44669724 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.43 5.28 0.31 2.75e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.04 -0.3 8.78e-7 Glomerular filtration rate (creatinine); CESC cis rs35110281 0.837 rs2838340 chr21:45076373 A/G cg21573476 chr21:45109991 RRP1B -0.42 -5.92 -0.34 1e-8 Mean corpuscular volume; CESC cis rs11098499 0.954 rs10017371 chr4:120293776 A/G cg09307838 chr4:120376055 NA 0.93 12.84 0.62 1.17e-29 Corneal astigmatism; CESC cis rs4820539 0.966 rs5996470 chr22:23483255 G/A cg14186256 chr22:23484241 RTDR1 0.87 16.05 0.7 5.72e-41 Bone mineral density; CESC cis rs7116495 1.000 rs10128658 chr11:71733519 C/T cg26138937 chr11:71823887 C11orf51 -0.77 -6.19 -0.36 2.3e-9 Severe influenza A (H1N1) infection; CESC cis rs10751667 0.643 rs7395592 chr11:934094 C/G cg20946044 chr11:1010712 AP2A2 -0.38 -5.21 -0.3 3.83e-7 Alzheimer's disease (late onset); CESC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg10691866 chr7:65817282 TPST1 -0.31 -5.08 -0.3 7e-7 Aortic root size; CESC trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21582582 chr3:182698605 DCUN1D1 -0.44 -6.0 -0.35 6.29e-9 Intelligence (multi-trait analysis); CESC cis rs12791968 0.765 rs12794751 chr11:44998769 C/G cg11846598 chr11:44996168 LOC221122 -0.49 -5.91 -0.34 1.07e-8 Inhibitory control; CESC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg16606324 chr3:10149918 C3orf24 0.43 5.22 0.31 3.71e-7 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20074569 chr22:42372516 SEPT3 0.53 6.07 0.35 4.47e-9 Gut microbiome composition (summer); CESC cis rs6754311 0.731 rs13404551 chr2:136721995 T/C cg07169764 chr2:136633963 MCM6 0.71 9.2 0.49 1.07e-17 Mosquito bite size; CESC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.74 -8.32 -0.46 4.64e-15 Gut microbiome composition (summer); CESC cis rs6598955 0.612 rs12738188 chr1:26548029 G/C cg00852783 chr1:26633632 UBXN11 0.43 6.34 0.36 9.77e-10 Obesity-related traits; CESC cis rs7707921 0.522 rs9293290 chr5:81474225 A/T cg15871215 chr5:81402204 ATG10 -0.47 -6.82 -0.39 6.01e-11 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00249632 chr4:1872469 WHSC1 0.54 6.3 0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg06873352 chr17:61820015 STRADA 0.48 7.07 0.4 1.35e-11 Height; CESC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg18225595 chr11:63971243 STIP1 -0.53 -7.39 -0.41 1.96e-12 Platelet count; CESC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.04 -0.3 8.58e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1878931 0.624 rs27241 chr16:3447282 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.8 -9.75 -0.51 2.17e-19 Body mass index (adult); CESC cis rs7308134 0.653 rs73032440 chr12:1988912 G/A cg19708984 chr12:1973340 CACNA2D4 0.54 5.09 0.3 6.84e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC trans rs5756813 0.635 rs11089856 chr22:38205784 A/C cg19894588 chr14:64061835 NA -0.68 -8.41 -0.46 2.62e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs1808579 0.935 rs1805082 chr18:21120444 C/T cg14672496 chr18:21087552 C18orf8 -0.37 -5.72 -0.33 2.86e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs6540556 0.954 rs6685077 chr1:209933331 A/G cg05527609 chr1:210001259 C1orf107 -0.45 -5.63 -0.33 4.66e-8 Red blood cell count; CESC cis rs12824058 0.798 rs7968728 chr12:130804696 T/A cg26677194 chr12:130822605 PIWIL1 0.49 6.24 0.36 1.74e-9 Menopause (age at onset); CESC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg18099408 chr3:52552593 STAB1 -0.32 -5.06 -0.3 7.8e-7 Bipolar disorder; CESC cis rs193541 0.632 rs173481 chr5:122254552 G/A cg19412675 chr5:122181750 SNX24 0.43 5.1 0.3 6.38e-7 Glucose homeostasis traits; CESC trans rs637571 0.522 rs28578718 chr11:65748400 C/A cg17712092 chr4:129076599 LARP1B 0.75 10.71 0.55 1.76e-22 Eosinophil percentage of white cells; CESC cis rs34779708 0.931 rs2490663 chr10:35329735 A/G cg03585969 chr10:35415529 CREM -0.74 -9.91 -0.52 6.61e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg00876541 chr19:10515578 MIR1181;CDC37 -0.46 -6.04 -0.35 5.09e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4975709 0.569 rs2353583 chr5:1858834 G/C cg17650747 chr5:1873721 NA 0.45 6.02 0.35 5.77e-9 Cardiovascular disease risk factors; CESC cis rs10170846 0.861 rs4674677 chr2:223529658 G/A cg25565276 chr2:223520875 FARSB 0.51 7.09 0.4 1.19e-11 Schizophrenia (inflammation and infection response interaction); CESC cis rs7605827 0.897 rs4140714 chr2:15515723 T/A cg19274914 chr2:15703543 NA 0.31 5.39 0.31 1.55e-7 Educational attainment (years of education); CESC cis rs9894429 0.646 rs12603868 chr17:79618834 G/C cg13777783 chr17:79615861 NA -0.31 -5.11 -0.3 6.2e-7 Eye color traits; CESC cis rs793571 0.502 rs395601 chr15:59063196 G/C cg05156742 chr15:59063176 FAM63B 0.79 11.5 0.58 4.28e-25 Schizophrenia; CESC cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg17971929 chr21:40555470 PSMG1 0.7 9.64 0.51 4.85e-19 Cognitive function; CESC cis rs1801251 1.000 rs1867778 chr2:233679644 C/T cg08000102 chr2:233561755 GIGYF2 -0.68 -9.89 -0.52 7.66e-20 Coronary artery disease; CESC cis rs11676348 0.846 rs6723449 chr2:218997580 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.44 5.93 0.34 9.61e-9 Ulcerative colitis; CESC cis rs1669338 0.588 rs62228634 chr3:3184985 A/G cg16797762 chr3:3221439 CRBN -0.56 -6.14 -0.35 2.95e-9 White matter integrity; CESC cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.08 13.37 0.63 1.66e-31 Smoking behavior; CESC cis rs3820928 1.000 rs10193404 chr2:227777757 A/G cg11843606 chr2:227700838 RHBDD1 -0.43 -5.8 -0.34 1.84e-8 Pulmonary function; CESC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg16325326 chr1:53192061 ZYG11B -0.71 -11.84 -0.59 3e-26 Monocyte count; CESC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg11764359 chr7:65958608 NA -0.78 -11.32 -0.57 1.76e-24 Aortic root size; CESC cis rs8060686 0.641 rs79323429 chr16:68084594 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.16 -0.35 2.65e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs10911251 0.546 rs1062044 chr1:183112412 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.22 0.63 5.53e-31 Colorectal cancer; CESC cis rs7208859 0.673 rs9909497 chr17:29173228 C/A cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7605827 0.964 rs6733847 chr2:15564930 G/A cg19274914 chr2:15703543 NA 0.35 6.29 0.36 1.3e-9 Educational attainment (years of education); CESC cis rs3857067 0.740 rs6532470 chr4:95108211 C/G cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.05 -0.49 3.25e-17 QT interval; CESC cis rs4835473 0.932 rs10857415 chr4:144829906 C/T cg25736465 chr4:144833511 NA 0.41 6.32 0.36 1.09e-9 Immature fraction of reticulocytes; CESC cis rs6062302 0.548 rs6089940 chr20:62252695 C/T cg09650180 chr20:62225654 GMEB2 -0.82 -9.32 -0.5 4.63e-18 Glioblastoma; CESC cis rs7980687 0.506 rs1611973 chr12:123622731 C/G cg00376283 chr12:123451042 ABCB9 0.69 9.71 0.51 2.96e-19 Height;Educational attainment;Head circumference (infant); CESC cis rs1018836 0.923 rs6998150 chr8:91645969 A/C cg16814680 chr8:91681699 NA -0.74 -10.39 -0.54 1.92e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs6580649 0.941 rs7312326 chr12:48480643 G/A cg05342945 chr12:48394962 COL2A1 0.5 5.74 0.33 2.59e-8 Lung cancer; CESC cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg00149659 chr3:10157352 C3orf10 0.98 11.92 0.59 1.59e-26 Alzheimer's disease; CESC cis rs13223928 0.511 rs11773338 chr7:3144508 T/C cg19214707 chr7:3157722 NA -0.4 -5.34 -0.31 2.02e-7 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs12912251 0.591 rs2643216 chr15:39003809 C/G cg10631289 chr15:39006617 NA -0.48 -5.13 -0.3 5.51e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs72627123 0.867 rs113257091 chr14:74461121 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.75 5.27 0.31 2.89e-7 Morning vs. evening chronotype; CESC cis rs2249625 0.967 rs2496532 chr6:72919917 A/T cg18830697 chr6:72922368 RIMS1 -0.45 -6.36 -0.36 8.97e-10 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg05564831 chr3:52568323 NT5DC2 0.53 8.95 0.48 6.22e-17 Electroencephalogram traits; CESC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg07395648 chr5:131743802 NA -0.43 -5.67 -0.33 3.73e-8 Breast cancer; CESC cis rs9457247 1.000 rs2149085 chr6:167371110 T/C cg25258033 chr6:167368657 RNASET2 -0.42 -6.24 -0.36 1.73e-9 Crohn's disease; CESC cis rs12912251 1.000 rs2172835 chr15:38990171 C/T cg01338139 chr15:38987640 C15orf53 -0.48 -5.71 -0.33 2.99e-8 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs72781680 0.898 rs6712524 chr2:24083925 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.63 0.33 4.49e-8 Lymphocyte counts; CESC cis rs17253792 0.915 rs17832389 chr14:56185836 A/G cg01858014 chr14:56050164 KTN1 -0.93 -7.3 -0.41 3.33e-12 Putamen volume; CESC cis rs11638352 0.661 rs2555384 chr15:44420900 T/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -5.29 -0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs5753037 0.585 rs7954 chr22:30184950 A/G cg01021169 chr22:30184971 ASCC2 -0.57 -8.66 -0.47 4.71e-16 Type 1 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08230990 chr9:34377068 KIAA1161 -0.41 -6.1 -0.35 3.72e-9 Gambling; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11088380 chr13:25497236 CENPJ 0.53 7.04 0.4 1.62e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11711311 0.826 rs13077644 chr3:113467777 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.59 7.81 0.43 1.36e-13 IgG glycosylation; CESC cis rs589448 1.000 rs589448 chr12:69752200 A/G cg22834771 chr12:69754056 YEATS4 -0.54 -7.24 -0.41 4.92e-12 Cerebrospinal fluid biomarker levels; CESC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.74e-9 Prudent dietary pattern; CESC cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs10045504 0.502 rs17456482 chr5:38737783 G/C cg15396434 chr5:38725168 NA -0.73 -6.84 -0.39 5.61e-11 Night sleep phenotypes; CESC cis rs36051895 0.632 rs61461940 chr9:5157277 T/C cg02405213 chr9:5042618 JAK2 -0.47 -5.84 -0.34 1.53e-8 Pediatric autoimmune diseases; CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg03188948 chr7:1209495 NA 0.46 6.01 0.35 6.1e-9 Longevity;Endometriosis; CESC cis rs1707322 0.964 rs12067716 chr1:46434428 T/A cg03146154 chr1:46216737 IPP 0.78 10.68 0.55 2.25e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9611565 0.765 rs132908 chr22:41801795 G/A cg17376030 chr22:41985996 PMM1 -0.68 -7.12 -0.4 1.02e-11 Vitiligo; CESC cis rs939658 0.776 rs35904425 chr15:79444567 G/A cg17916960 chr15:79447300 NA -0.36 -5.88 -0.34 1.22e-8 Refractive error; CESC cis rs1005277 0.579 rs2800485 chr10:38542588 G/A cg25427524 chr10:38739819 LOC399744 -0.73 -10.76 -0.55 1.24e-22 Extrinsic epigenetic age acceleration; CESC cis rs6460942 1.000 rs7792759 chr7:12311715 A/G cg20607287 chr7:12443886 VWDE 0.64 7.01 0.4 1.93e-11 Coronary artery disease; CESC cis rs950776 0.518 rs12906951 chr15:78825562 C/T cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs9790314 1.000 rs1382428 chr3:161032386 A/C cg03342759 chr3:160939853 NMD3 -0.48 -6.25 -0.36 1.61e-9 Morning vs. evening chronotype; CESC trans rs11098499 0.954 rs10006525 chr4:120408931 T/G cg25214090 chr10:38739885 LOC399744 0.71 10.17 0.53 9.87e-21 Corneal astigmatism; CESC cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg02733842 chr7:1102375 C7orf50 -0.38 -5.21 -0.3 3.76e-7 Bronchopulmonary dysplasia; CESC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg11494091 chr17:61959527 GH2 0.72 12.13 0.6 3.12e-27 Prudent dietary pattern; CESC cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg18876405 chr7:65276391 NA -0.5 -5.83 -0.34 1.62e-8 Aortic root size; CESC cis rs962856 0.575 rs6740919 chr2:67620055 C/G cg09028215 chr2:67624308 ETAA1 0.41 5.25 0.31 3.06e-7 Pancreatic cancer; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg16321474 chr12:48299386 VDR 0.49 6.44 0.37 5.43e-10 Psoriatic arthritis; CESC cis rs2070488 0.775 rs4371464 chr3:38548021 T/C cg24069376 chr3:38537580 EXOG -0.32 -5.51 -0.32 8.63e-8 Electrocardiographic conduction measures; CESC trans rs11992162 0.967 rs10108320 chr8:11832263 A/T cg15556689 chr8:8085844 FLJ10661 -0.52 -6.1 -0.35 3.72e-9 Monocyte count; CESC cis rs9291683 0.546 rs13129453 chr4:10044784 T/C cg00071950 chr4:10020882 SLC2A9 0.81 13.65 0.64 1.7e-32 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06848247 chr2:6635800 NA -0.59 -7.23 -0.41 5.14e-12 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08151832 chr16:66835414 CCDC79 0.51 7.01 0.4 1.97e-11 Fibrinogen levels; CESC cis rs753778 0.628 rs1045248 chr8:142204326 C/G cg18755752 chr8:142205143 DENND3 -0.67 -10.02 -0.52 2.95e-20 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs1371867 0.846 rs1788167 chr8:101319996 C/T cg11906718 chr8:101322791 RNF19A 0.46 5.92 0.34 1.02e-8 Atrioventricular conduction; CESC cis rs977987 0.806 rs72787160 chr16:75445162 G/C cg03315344 chr16:75512273 CHST6 0.41 5.86 0.34 1.35e-8 Dupuytren's disease; CESC cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg13175981 chr1:150552382 MCL1 0.72 10.91 0.56 3.88e-23 Tonsillectomy; CESC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg04267008 chr7:1944627 MAD1L1 -0.61 -7.42 -0.41 1.57e-12 Bipolar disorder and schizophrenia; CESC cis rs6502050 0.835 rs4641801 chr17:80154021 G/A cg23985595 chr17:80112537 CCDC57 -0.4 -6.42 -0.37 6.32e-10 Life satisfaction; CESC cis rs9898 0.589 rs6767451 chr3:186366216 A/G cg17206748 chr3:186370508 FETUB 0.3 5.06 0.3 7.97e-7 Cerebrospinal fluid biomarker levels;Activated partial thromboplastin time; CESC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg14829155 chr15:31115871 NA -0.7 -9.48 -0.5 1.51e-18 Huntington's disease progression; CESC cis rs34779708 0.741 rs34397613 chr10:35550313 A/G cg04310649 chr10:35416472 CREM -0.46 -5.23 -0.31 3.48e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs116095464 0.558 rs56043030 chr5:220917 A/G cg22496380 chr5:211416 CCDC127 -0.72 -8.57 -0.47 8.59e-16 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12145550 chr20:44600942 ZNF335 -0.38 -6.18 -0.35 2.43e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08198330 chr19:15483731 AKAP8 -0.55 -6.12 -0.35 3.4e-9 Gut microbiome composition (summer); CESC cis rs8058578 1.000 rs6565197 chr16:30706477 T/C cg02466173 chr16:30829666 NA -0.4 -6.38 -0.36 8.06e-10 Multiple myeloma; CESC trans rs56114371 0.777 rs200483 chr6:27774824 C/T cg06606381 chr12:133084897 FBRSL1 -0.8 -8.14 -0.45 1.52e-14 Breast cancer; CESC cis rs796364 0.806 rs78527234 chr2:200913453 C/T cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC cis rs72781680 0.898 rs113027486 chr2:24098371 G/A cg20701182 chr2:24300061 SF3B14 0.62 5.68 0.33 3.54e-8 Lymphocyte counts; CESC cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg20891283 chr12:69753455 YEATS4 1.0 17.29 0.73 2.3e-45 Cerebrospinal fluid biomarker levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26030974 chr17:45266791 CDC27 0.56 6.4 0.37 6.83e-10 Gut microbiome composition (summer); CESC cis rs7216064 1.000 rs12451511 chr17:65874861 T/G cg07042672 chr17:66097459 LOC651250 -0.52 -5.4 -0.31 1.5e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg18446336 chr7:2847575 GNA12 -0.4 -5.97 -0.34 7.59e-9 Height; CESC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -5.18 -0.3 4.41e-7 Developmental language disorder (linguistic errors); CESC cis rs8180040 0.966 rs3816779 chr3:47543389 C/T cg27129171 chr3:47204927 SETD2 0.6 8.87 0.48 1.1e-16 Colorectal cancer; CESC cis rs9303401 0.614 rs2333409 chr17:57139134 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.91 11.32 0.57 1.71e-24 Cognitive test performance; CESC cis rs35110281 0.744 rs230644 chr21:44917183 C/T cg01579765 chr21:45077557 HSF2BP 0.52 8.88 0.48 1.06e-16 Mean corpuscular volume; CESC cis rs9796 0.553 rs7171437 chr15:41315168 G/A cg02330683 chr15:41787940 ITPKA 0.39 5.33 0.31 2.12e-7 Menopause (age at onset); CESC cis rs1904096 0.506 rs12511433 chr4:95162425 G/A cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.62 -0.51 5.56e-19 Type 2 diabetes; CESC cis rs9916302 0.610 rs11078902 chr17:37631883 C/G cg00129232 chr17:37814104 STARD3 -0.53 -6.91 -0.39 3.67e-11 Glomerular filtration rate (creatinine); CESC cis rs1567558 0.554 rs2048459 chr3:140935717 G/A cg16418163 chr3:140950828 ACPL2 -0.39 -5.03 -0.3 9.1e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs4718428 0.705 rs10267335 chr7:66403220 G/T cg18252515 chr7:66147081 NA -0.47 -5.34 -0.31 2.01e-7 Corneal structure; CESC cis rs6464772 0.540 rs10952668 chr7:140143520 C/T cg17228231 chr7:140178305 MKRN1 0.51 6.88 0.39 4.37e-11 Creatinine levels in ischemic stroke; CESC cis rs80282103 0.618 rs74117850 chr10:1165777 T/C cg08668510 chr10:1095578 IDI1 0.74 5.91 0.34 1.07e-8 Glomerular filtration rate (creatinine); CESC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg08470875 chr2:26401718 FAM59B 0.58 6.37 0.36 8.15e-10 Gut microbiome composition (summer); CESC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg18032046 chr6:28092343 ZSCAN16 0.44 5.3 0.31 2.46e-7 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04962756 chr11:65425928 RELA -0.47 -6.09 -0.35 4.05e-9 Gut microbiome composition (summer); CESC cis rs3126085 0.935 rs114825811 chr1:152231877 G/A cg03465714 chr1:152285911 FLG 0.49 5.42 0.32 1.36e-7 Atopic dermatitis; CESC cis rs1538970 0.924 rs10890327 chr1:45891458 C/T cg05343316 chr1:45956843 TESK2 0.89 12.41 0.61 3.59e-28 Platelet count; CESC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -10.96 -0.56 2.74e-23 Initial pursuit acceleration; CESC cis rs523522 0.924 rs11065150 chr12:120958875 T/G cg27279351 chr12:120934652 DYNLL1 0.69 9.03 0.49 3.56e-17 High light scatter reticulocyte count; CESC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg22800045 chr5:56110881 MAP3K1 -0.51 -5.98 -0.35 7.02e-9 Coronary artery disease; CESC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg07701084 chr6:150067640 NUP43 0.45 6.23 0.36 1.86e-9 Lung cancer; CESC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg06212747 chr3:49208901 KLHDC8B 0.72 10.97 0.56 2.5e-23 Menarche (age at onset); CESC cis rs72634258 0.554 rs7556518 chr1:7847846 G/A cg26816564 chr1:7831052 VAMP3 0.65 5.91 0.34 1.03e-8 Inflammatory bowel disease; CESC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.87e-17 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01192531 chr20:34287185 ROMO1;NFS1 0.63 7.07 0.4 1.37e-11 Gut microbiome composition (summer); CESC cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg05347473 chr6:146136440 FBXO30 -0.72 -9.24 -0.49 8.06e-18 Lobe attachment (rater-scored or self-reported); CESC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg02461776 chr11:598696 PHRF1 0.49 5.48 0.32 9.76e-8 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21308919 chr4:140619560 MGST2 -0.56 -6.83 -0.39 5.8200000000000003e-11 Gut microbiome composition (summer); CESC cis rs8067545 0.516 rs11869258 chr17:20206898 G/A cg13482628 chr17:19912719 NA -0.42 -5.61 -0.33 5.2e-8 Schizophrenia; CESC trans rs10435719 0.702 rs77055881 chr8:11790581 T/C cg15556689 chr8:8085844 FLJ10661 0.52 6.36 0.36 8.63e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs28374715 0.532 rs1899 chr15:41689232 C/T cg02330683 chr15:41787940 ITPKA 0.43 5.28 0.31 2.72e-7 Ulcerative colitis; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg02051553 chr1:10044519 NMNAT1 -0.46 -6.22 -0.36 1.89e-9 Bronchopulmonary dysplasia; CESC cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg08847533 chr14:75593920 NEK9 -0.85 -14.01 -0.65 9.35e-34 Height; CESC cis rs9549260 0.709 rs4581585 chr13:41203905 C/T cg21288729 chr13:41239152 FOXO1 0.63 8.4 0.46 2.8e-15 Red blood cell count; CESC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg06494592 chr3:125709126 NA -0.49 -5.2 -0.3 3.92e-7 Blood pressure (smoking interaction); CESC cis rs17376456 0.597 rs7733142 chr5:93322795 C/A cg25358565 chr5:93447407 FAM172A -0.46 -5.43 -0.32 1.28e-7 Diabetic retinopathy; CESC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9660992 0.674 rs72745221 chr1:205262337 G/A cg00857998 chr1:205179979 DSTYK 0.49 5.51 0.32 8.52e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg13918804 chr1:2043761 PRKCZ 0.27 5.12 0.3 5.84e-7 Height; CESC cis rs4925386 0.840 rs6143024 chr20:60914229 A/G cg06026331 chr20:60912101 LAMA5 0.48 5.15 0.3 5.09e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg12826209 chr6:26865740 GUSBL1 0.75 8.45 0.46 1.9e-15 Intelligence (multi-trait analysis); CESC cis rs7843479 0.965 rs11135741 chr8:21801091 C/T cg17168535 chr8:21777572 XPO7 0.51 6.96 0.39 2.6e-11 Mean corpuscular volume; CESC cis rs9443189 0.570 rs661229 chr6:76293793 G/A cg01950844 chr6:76311363 SENP6 0.87 9.54 0.51 9.61e-19 Prostate cancer; CESC cis rs67478160 0.619 rs12437066 chr14:104236844 A/C cg01849466 chr14:104193079 ZFYVE21 -0.54 -7.78 -0.43 1.62e-13 Schizophrenia; CESC cis rs8060686 0.516 rs4567701 chr16:68163662 T/C cg26727032 chr16:67993705 SLC12A4 -0.55 -7.65 -0.43 3.84e-13 HDL cholesterol;Metabolic syndrome; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27315239 chr1:53593711 SLC1A7 0.44 6.36 0.36 8.62e-10 Gut microbiota (bacterial taxa); CESC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.52 5.7 0.33 3.12e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg11644478 chr21:40555479 PSMG1 -0.52 -7.01 -0.4 2.03e-11 Menarche (age at onset); CESC cis rs2637266 0.703 rs6480836 chr10:78446866 C/T cg18941641 chr10:78392320 NA 0.4 7.27 0.41 4.01e-12 Pulmonary function; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg01024009 chr3:145968696 PLSCR4 0.53 6.96 0.39 2.74e-11 Myopia (pathological); CESC cis rs2280018 0.609 rs2941253 chr16:15173746 G/A cg27102117 chr16:15229624 NA 0.55 8.39 0.46 2.89e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7078219 0.714 rs10883369 chr10:101291367 C/T cg09788492 chr10:101292477 NKX2-3 0.31 5.05 0.3 8.24e-7 Dental caries; CESC cis rs8062405 0.754 rs62034323 chr16:28536473 C/T cg07382826 chr16:28625726 SULT1A1 0.31 5.05 0.3 8.32e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9549367 0.789 rs2287244 chr13:113887173 C/G cg00898013 chr13:113819073 PROZ 0.48 7.0 0.4 2.09e-11 Platelet distribution width; CESC cis rs8071756 1.000 rs8071756 chr17:1574342 C/T ch.17.72133F chr17:1577994 PRPF8 -0.5 -5.44 -0.32 1.22e-7 Blood protein levels; CESC cis rs10129255 0.500 rs2105991 chr14:107138039 C/G cg23076370 chr14:107095027 NA -0.62 -9.36 -0.5 3.53e-18 Kawasaki disease; CESC cis rs796364 0.806 rs11684895 chr2:201009026 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -6.48 -0.37 4.47e-10 Schizophrenia; CESC cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg24110177 chr3:50126178 RBM5 -0.52 -6.97 -0.39 2.45e-11 Intelligence (multi-trait analysis); CESC cis rs367943 0.637 rs6891711 chr5:113009026 G/T cg12552261 chr5:112820674 MCC -0.45 -5.6 -0.33 5.26e-8 Type 2 diabetes; CESC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg22535103 chr8:58192502 C8orf71 -1.07 -13.81 -0.65 4.87e-33 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg07936489 chr17:37558343 FBXL20 0.82 11.93 0.59 1.54e-26 Glomerular filtration rate (creatinine); CESC cis rs2180341 0.924 rs9285459 chr6:127631113 T/C cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6e-39 Breast cancer; CESC cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 2e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs2637266 1.000 rs10219023 chr10:78364537 G/A cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs7264396 0.563 rs6060580 chr20:34310512 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.91 -10.67 -0.55 2.46e-22 Total cholesterol levels; CESC cis rs7809950 0.954 rs2520243 chr7:107136973 T/C cg23024343 chr7:107201750 COG5 -0.43 -6.08 -0.35 4.11e-9 Coronary artery disease; CESC cis rs8081692 1 rs8081692 chr17:38154595 A/G cg17467752 chr17:38218738 THRA 0.67 10.02 0.52 3.12e-20 Neutrophil count; CESC cis rs6460942 0.659 rs13247370 chr7:12514632 T/C cg06484146 chr7:12443880 VWDE -0.64 -7.17 -0.4 7.7e-12 Coronary artery disease; CESC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.84 0.34 1.55e-8 Tonsillectomy; CESC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg09455208 chr3:40491958 NA 0.52 8.48 0.46 1.61e-15 Renal cell carcinoma; CESC cis rs1448094 0.817 rs10863121 chr12:86343834 A/C cg02569458 chr12:86230093 RASSF9 -0.37 -5.44 -0.32 1.22e-7 Major depressive disorder; CESC trans rs73568641 0.508 rs73572679 chr6:154101173 C/A cg08374472 chr16:87445639 ZCCHC14 -0.46 -6.29 -0.36 1.28e-9 Methadone dose in opioid dependence; CESC trans rs561341 1.000 rs2470267 chr17:30274132 G/A cg27661571 chr11:113659931 NA -0.68 -6.86 -0.39 4.92e-11 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg11494091 chr17:61959527 GH2 0.73 12.49 0.61 1.88e-28 Prudent dietary pattern; CESC trans rs3780486 0.834 rs75443249 chr9:33149207 A/G cg04842962 chr6:43655489 MRPS18A 0.89 13.28 0.63 3.36e-31 IgG glycosylation; CESC trans rs11039798 0.588 rs59777067 chr11:49015350 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.64 0.38 1.72e-10 Axial length; CESC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.48e-10 Depression; CESC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg25985355 chr7:65971099 NA -0.31 -5.21 -0.3 3.79e-7 Aortic root size; CESC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg08027265 chr7:2291960 NA -0.35 -5.22 -0.31 3.56e-7 Bipolar disorder and schizophrenia; CESC cis rs4253772 0.591 rs6008538 chr22:46685963 G/A cg09491104 chr22:46646882 C22orf40 -0.64 -9.33 -0.5 4.39e-18 LDL cholesterol;Cholesterol, total; CESC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg13126279 chr21:47581558 C21orf56 -0.49 -6.63 -0.38 1.83e-10 Testicular germ cell tumor; CESC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg02018176 chr4:1364513 KIAA1530 0.46 6.7 0.38 1.23e-10 Longevity; CESC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.04e-8 Lung cancer; CESC cis rs950169 1.000 rs62026530 chr15:84775840 G/T cg17507749 chr15:85114479 UBE2QP1 0.6 6.5 0.37 3.92e-10 Schizophrenia; CESC cis rs7264396 0.623 rs2425127 chr20:34332037 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.84 0.39 5.48e-11 Total cholesterol levels; CESC cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.18e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.87 10.01 0.52 3.2e-20 Platelet count; CESC cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg18769074 chr3:133464867 TF 0.32 6.1 0.35 3.64e-9 Iron status biomarkers (transferrin levels); CESC cis rs7208859 0.623 rs8075341 chr17:29136565 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1401999 1.000 rs939336 chr3:183685534 A/G cg01324343 chr3:183735012 ABCC5 0.62 13.06 0.63 1.92e-30 Anterior chamber depth; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27587257 chr11:1002310 AP2A2 -0.5 -6.12 -0.35 3.41e-9 Gut microbiome composition (summer); CESC cis rs818427 0.896 rs818429 chr5:112220534 T/C cg07820702 chr5:112228657 REEP5 -0.47 -6.13 -0.35 3.22e-9 Total body bone mineral density; CESC cis rs889312 0.500 rs866223 chr5:56125353 A/G cg14703610 chr5:56206110 C5orf35 0.5 6.66 0.38 1.56e-10 Breast cancer;Breast cancer (early onset); CESC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg17279839 chr7:150038598 RARRES2 0.43 5.31 0.31 2.31e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg08109568 chr15:31115862 NA -0.71 -9.63 -0.51 5.02e-19 Huntington's disease progression; CESC cis rs6484504 0.576 rs208088 chr11:31192686 T/C cg14844989 chr11:31128820 NA -0.42 -5.91 -0.34 1.05e-8 Red blood cell count; CESC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.52 7.86 0.43 9.89e-14 Bipolar disorder; CESC cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.91e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2795502 0.873 rs3123753 chr10:43404899 C/T cg20628663 chr10:43360327 NA 0.53 5.93 0.34 9.29e-9 Blood protein levels; CESC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg20891283 chr12:69753455 YEATS4 0.91 15.03 0.68 2.41e-37 Blood protein levels; CESC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg14298792 chr15:30685198 CHRFAM7A -0.48 -5.72 -0.33 2.81e-8 Huntington's disease progression; CESC cis rs9467711 0.606 rs2073531 chr6:26375256 A/G cg14345882 chr6:26364793 BTN3A2 0.63 6.39 0.37 7.52e-10 Autism spectrum disorder or schizophrenia; CESC trans rs61931739 0.500 rs11053185 chr12:34428857 A/G cg26384229 chr12:38710491 ALG10B 0.53 7.27 0.41 3.96e-12 Morning vs. evening chronotype; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00926502 chr13:103451549 BIVM;KDELC1 0.5 6.61 0.38 2.11e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7178572 0.568 rs12443386 chr15:77491389 C/T cg22256960 chr15:77711686 NA 0.53 6.38 0.36 7.89e-10 Type 2 diabetes; CESC cis rs7845219 0.525 rs3019175 chr8:95949013 G/A cg16049864 chr8:95962084 TP53INP1 -0.46 -6.61 -0.38 2.16e-10 Type 2 diabetes; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg15421363 chr5:131826865 IRF1 -0.44 -6.03 -0.35 5.52e-9 Recombination measurement; CESC cis rs853679 1.000 rs1778511 chr6:28229411 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL -0.71 -7.39 -0.41 1.97e-12 Depression; CESC cis rs10751667 0.643 rs10902257 chr11:973577 T/C cg06064525 chr11:970664 AP2A2 -0.46 -8.92 -0.48 7.68e-17 Alzheimer's disease (late onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09622330 chr16:10205262 GRIN2A 0.5 7.26 0.41 4.19e-12 Fibrinogen levels; CESC cis rs2479724 0.870 rs6902650 chr6:41764080 G/A cg08135965 chr6:41755394 TOMM6 -0.4 -5.39 -0.31 1.58e-7 Menarche (age at onset); CESC cis rs8114671 0.586 rs6087634 chr20:33413809 G/A cg06115741 chr20:33292138 TP53INP2 0.44 5.17 0.3 4.66e-7 Height; CESC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg22963979 chr7:1858916 MAD1L1 0.39 5.52 0.32 8.12e-8 Bipolar disorder and schizophrenia; CESC cis rs77956314 0.515 rs10850741 chr12:117432004 A/G cg25972092 chr12:117363249 FBXW8 0.51 5.69 0.33 3.34e-8 Subcortical brain region volumes;Hippocampal volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06466203 chr10:89623360 PTEN;KILLIN -0.43 -6.8 -0.39 6.82e-11 Gambling; CESC cis rs2288073 0.562 rs112892911 chr2:24590800 G/A cg06627628 chr2:24431161 ITSN2 -0.99 -11.28 -0.57 2.4e-24 Venous thromboembolism (SNP x SNP interaction); CESC cis rs7810240 1.000 rs56333034 chr7:150093330 G/A cg10018233 chr7:150070692 REPIN1 -0.32 -5.55 -0.32 7.08e-8 Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg06481639 chr22:41940642 POLR3H -0.6 -6.11 -0.35 3.47e-9 Vitiligo; CESC cis rs12682352 0.652 rs1567398 chr8:8726804 A/C cg17143192 chr8:8559678 CLDN23 -0.44 -5.59 -0.32 5.59e-8 Neuroticism; CESC cis rs9486719 0.947 rs2472893 chr6:96870048 G/C cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs5769707 0.967 rs5769698 chr22:49997706 A/G cg20744362 chr22:50050164 C22orf34 0.44 7.53 0.42 7.96e-13 Monocyte count;Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12882657 chr12:125448964 DHX37 -0.67 -7.44 -0.42 1.41e-12 Gut microbiome composition (summer); CESC cis rs11690935 0.959 rs10204501 chr2:172588865 C/G cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.97 -0.68 4e-37 Schizophrenia; CESC cis rs6740322 0.644 rs11690918 chr2:43474112 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.73 -8.0 -0.44 3.88e-14 Coronary artery disease; CESC cis rs6032067 0.777 rs62208382 chr20:43785549 C/T cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19630102 chr14:68067023 PIGH 0.48 6.18 0.35 2.35e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2072732 0.861 rs72629497 chr1:2954123 T/C cg15211996 chr1:2936768 ACTRT2 0.34 6.04 0.35 5.27e-9 Plateletcrit; CESC cis rs727505 1.000 rs10281582 chr7:124423688 A/G cg23710748 chr7:124431027 NA -0.39 -6.48 -0.37 4.35e-10 Lewy body disease; CESC cis rs7808935 0.628 rs62451116 chr7:27938980 A/G cg05786569 chr7:27702416 HIBADH 0.52 5.86 0.34 1.39e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22396279 chr1:154580739 ADAR 0.59 6.81 0.39 6.44e-11 Gut microbiome composition (summer); CESC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.42e-7 Lung cancer; CESC cis rs78889164 0.562 rs1005731 chr19:33908717 A/C cg02272751 chr19:33882848 PEPD -0.39 -5.4 -0.31 1.49e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs9840812 0.645 rs13068119 chr3:136206369 A/G cg15507776 chr3:136538369 TMEM22 -0.5 -5.39 -0.31 1.53e-7 Fibrinogen levels; CESC cis rs4481887 0.927 rs4460676 chr1:248431781 G/A cg00666640 chr1:248458726 OR2T12 0.41 6.81 0.39 6.53e-11 Common traits (Other); CESC cis rs826838 1.000 rs34254519 chr12:39041235 G/A cg13010199 chr12:38710504 ALG10B 0.58 8.07 0.44 2.51e-14 Heart rate; CESC cis rs17826219 0.568 rs9907834 chr17:29154013 G/A cg19761014 chr17:28927070 LRRC37B2 0.74 6.03 0.35 5.43e-9 Body mass index; CESC cis rs9303401 0.646 rs9303403 chr17:57219300 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.51 -6.38 -0.36 8e-10 Cognitive test performance; CESC cis rs4820539 0.966 rs2267005 chr22:23461723 A/G cg14186256 chr22:23484241 RTDR1 0.8 14.1 0.65 4.41e-34 Bone mineral density; CESC cis rs7107174 0.688 rs10899501 chr11:78131408 C/T cg02023728 chr11:77925099 USP35 0.43 5.45 0.32 1.17e-7 Testicular germ cell tumor; CESC cis rs12479064 0.724 rs28369945 chr2:100080928 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.53 -6.04 -0.35 5.28e-9 Chronic sinus infection; CESC cis rs6540556 0.521 rs9430015 chr1:209911734 G/A cg05527609 chr1:210001259 C1orf107 -0.44 -5.18 -0.3 4.42e-7 Red blood cell count; CESC cis rs7086627 0.515 rs4934189 chr10:82214792 C/T cg00277334 chr10:82204260 NA -0.91 -15.72 -0.69 8.67e-40 Post bronchodilator FEV1; CESC cis rs10463316 0.894 rs7727926 chr5:150767216 G/A cg03212797 chr5:150827313 SLC36A1 -0.47 -6.2 -0.36 2.17e-9 Metabolite levels (Pyroglutamine); CESC cis rs3740713 1.000 rs60376560 chr11:18453742 A/T cg23797887 chr11:18477753 LDHAL6A -0.54 -5.22 -0.31 3.61e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9790314 0.521 rs1450523 chr3:161077270 G/A cg03342759 chr3:160939853 NMD3 -0.41 -5.95 -0.34 8.38e-9 Morning vs. evening chronotype; CESC trans rs877282 0.945 rs11253390 chr10:788678 A/G cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg00080972 chr5:178986291 RUFY1 0.47 7.68 0.43 3.18e-13 Lung cancer; CESC cis rs10876993 0.893 rs4760168 chr12:58087737 T/G cg18357645 chr12:58087776 OS9 0.63 10.42 0.54 1.53e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs12762955 0.687 rs4880470 chr10:1077480 G/A cg26597838 chr10:835615 NA -0.43 -5.4 -0.32 1.45e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs2652822 0.525 rs11634159 chr15:63507422 C/T cg02713581 chr15:63449717 RPS27L 0.49 6.35 0.36 9.23e-10 Metabolic traits; CESC cis rs2073300 0.609 rs3746737 chr20:23424638 C/T cg12062639 chr20:23401060 NAPB 1.09 8.31 0.45 5.13e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs17508449 0.865 rs4838993 chr1:114135133 C/T cg23652354 chr22:38005183 GGA1 -0.76 -6.08 -0.35 4.12e-9 Leprosy; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg18528216 chr8:66617288 MTFR1 0.4 6.1 0.35 3.72e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 5.87 0.34 1.27e-8 Bipolar disorder; CESC cis rs4925386 0.802 rs6142735 chr20:60918087 G/C cg24112000 chr20:60950667 NA -0.5 -5.87 -0.34 1.27e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg10556349 chr10:835070 NA 0.72 6.12 0.35 3.29e-9 Eosinophil percentage of granulocytes; CESC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg23281280 chr6:28129359 ZNF389 -0.6 -8.15 -0.45 1.47e-14 Depression; CESC cis rs6982240 1.000 rs6982240 chr8:142257378 A/T cg27411547 chr8:142287226 NA -0.43 -6.63 -0.38 1.86e-10 Tonsillectomy; CESC cis rs616402 0.527 rs2274985 chr1:10573867 G/A cg20482658 chr1:10539492 PEX14 -0.28 -5.83 -0.34 1.64e-8 Breast size; CESC cis rs6456156 0.792 rs4710181 chr6:167513998 T/C cg23791538 chr6:167370224 RNASET2 -0.4 -5.26 -0.31 2.92e-7 Primary biliary cholangitis; CESC cis rs6570726 0.935 rs385185 chr6:145814992 A/G cg05347473 chr6:146136440 FBXO30 0.5 6.71 0.38 1.15e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs1814175 0.645 rs847627 chr11:49927177 G/A cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs8060686 0.641 rs12445396 chr16:68155121 G/A cg26727032 chr16:67993705 SLC12A4 -0.53 -6.0 -0.35 6.32e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs61931739 0.963 rs59195137 chr12:34091838 G/A cg26384229 chr12:38710491 ALG10B -0.47 -6.56 -0.37 2.76e-10 Morning vs. evening chronotype; CESC cis rs35955747 0.902 rs131202 chr22:31709309 A/C cg25791279 chr22:32026902 PISD 0.47 5.57 0.32 6.26e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs7267979 1.000 rs7343481 chr20:25300113 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -18.7 -0.75 2.39e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs8141529 0.748 rs5762874 chr22:29269658 C/G cg02153584 chr22:29168773 CCDC117 0.57 7.51 0.42 9.31e-13 Lymphocyte counts; CESC cis rs7666738 0.830 rs6819047 chr4:98866902 G/A cg05340658 chr4:99064831 C4orf37 0.75 11.16 0.57 5.89e-24 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg02951883 chr7:2050386 MAD1L1 -0.58 -7.81 -0.43 1.38e-13 Bipolar disorder and schizophrenia; CESC cis rs8114671 0.562 rs6120746 chr20:33448496 A/G cg24642439 chr20:33292090 TP53INP2 0.42 5.03 0.3 9.22e-7 Height; CESC cis rs9354352 1.000 rs9354352 chr6:66696272 T/C cg07460842 chr6:66804631 NA 0.66 9.67 0.51 3.82e-19 Initial pursuit acceleration in psychotic disorders; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11895240 chr10:12171245 SEC61A2 0.56 6.21 0.36 2.04e-9 Gut microbiome composition (summer); CESC cis rs1790761 0.505 rs7945035 chr11:67348162 A/G cg00290607 chr11:67383545 NA -0.36 -5.33 -0.31 2.14e-7 Mean corpuscular volume; CESC cis rs1707322 0.682 rs10890334 chr1:46100378 A/T cg03146154 chr1:46216737 IPP 0.81 11.48 0.58 5.05e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1814175 0.645 rs1851857 chr11:49855589 A/C cg15704280 chr7:45808275 SEPT13 -1.01 -18.75 -0.76 1.62e-50 Height; CESC cis rs4979906 1.000 rs68092325 chr10:79446719 T/A cg07817648 chr10:79422355 NA -0.6 -6.39 -0.37 7.58e-10 Mortality in heart failure; CESC cis rs72901758 0.739 rs72901754 chr17:76244398 G/A cg26068271 chr17:76253126 NA 0.5 7.29 0.41 3.65e-12 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs11673344 0.528 rs563786 chr19:37412914 A/G cg27390819 chr19:37464633 NA -0.34 -5.12 -0.3 5.92e-7 Obesity-related traits; CESC cis rs2243480 1.000 rs56016656 chr7:65383481 C/T cg12463550 chr7:65579703 CRCP 0.71 5.5 0.32 8.79e-8 Diabetic kidney disease; CESC cis rs34779708 0.931 rs4934731 chr10:35431636 T/C cg04310649 chr10:35416472 CREM -0.54 -6.55 -0.37 2.9e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs752010 0.871 rs2038976 chr1:42094498 A/G cg06885757 chr1:42089581 HIVEP3 0.53 8.8 0.48 1.76e-16 Lupus nephritis in systemic lupus erythematosus; CESC cis rs240764 0.764 rs10457800 chr6:100936628 C/T cg21058520 chr6:100914733 NA 0.38 5.98 0.34 7.38e-9 Neuroticism; CESC cis rs10788309 0.506 rs4244943 chr10:85826908 G/A cg03623264 chr10:85672087 NA -0.41 -5.76 -0.33 2.28e-8 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); CESC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 4.07e-12 Major depressive disorder; CESC cis rs7592578 0.639 rs13417431 chr2:191293055 A/G cg10560079 chr2:191398806 TMEM194B -0.57 -5.78 -0.33 2.14e-8 Diastolic blood pressure; CESC cis rs13385 0.769 rs7705090 chr5:139618146 C/G cg26211634 chr5:139558579 C5orf32 0.48 5.28 0.31 2.75e-7 Atrial fibrillation; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15613982 chr20:18488017 SEC23B -0.47 -6.08 -0.35 4.07e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg22800045 chr5:56110881 MAP3K1 0.83 9.95 0.52 4.88e-20 Initial pursuit acceleration; CESC cis rs853679 0.882 rs9468287 chr6:28079741 G/T cg23372001 chr6:27791640 HIST1H4J 0.59 5.24 0.31 3.23e-7 Depression; CESC cis rs360798 0.512 rs1420018 chr2:63112500 A/G cg17519650 chr2:63277830 OTX1 0.53 6.28 0.36 1.37e-9 Coronary artery disease; CESC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg03806693 chr22:41940476 POLR3H 1.12 15.09 0.68 1.44e-37 Vitiligo; CESC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.6 -0.33 5.43e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs9346649 0.606 rs6940383 chr6:168491688 G/A cg09211372 chr6:168490623 NA -0.36 -5.28 -0.31 2.71e-7 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CESC cis rs2439831 1.000 rs2584726 chr15:43715382 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.79 11.89 0.59 2.12e-26 Lung cancer in ever smokers; CESC cis rs9322193 0.962 rs35443312 chr6:149991761 T/C cg07701084 chr6:150067640 NUP43 0.4 5.3 0.31 2.48e-7 Lung cancer; CESC trans rs4792192 1.000 rs4792192 chr17:11803461 A/G cg08005093 chr17:63532898 AXIN2 0.53 6.25 0.36 1.6e-9 Myopia (pathological); CESC cis rs4722166 0.568 rs1880241 chr7:22759469 A/G cg05265849 chr7:22767390 IL6 0.34 5.19 0.3 4.27e-7 Lung cancer; CESC cis rs2952156 1.000 rs2088126 chr17:37879030 A/G cg07936489 chr17:37558343 FBXL20 -0.51 -6.01 -0.35 6e-9 Asthma; CESC cis rs559928 0.606 rs61083753 chr11:63892665 C/T cg05555928 chr11:63887634 MACROD1 -0.49 -5.26 -0.31 2.93e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs6691722 0.503 rs3765425 chr1:24699872 G/C cg18323236 chr1:24743029 NIPAL3 0.4 5.95 0.34 8.62e-9 Response to interferon beta in multiple sclerosis; CESC cis rs7267979 1.000 rs2257432 chr20:25271086 T/C cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.13e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01941219 chr13:98795021 FARP1 0.56 6.16 0.35 2.68e-9 Gut microbiome composition (summer); CESC cis rs3820928 0.874 rs10199655 chr2:227892428 T/C cg05526886 chr2:227700861 RHBDD1 -0.45 -5.84 -0.34 1.51e-8 Pulmonary function; CESC cis rs847577 0.609 rs6965016 chr7:97807882 C/A cg24562669 chr7:97807699 LMTK2 0.83 13.66 0.64 1.57e-32 Breast cancer; CESC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg13866156 chr1:1669148 SLC35E2 -0.52 -6.81 -0.39 6.42e-11 Body mass index; CESC cis rs9291683 0.530 rs35908990 chr4:9976105 G/A cg00071950 chr4:10020882 SLC2A9 0.78 14.51 0.67 1.66e-35 Bone mineral density; CESC cis rs12618769 0.625 rs17034241 chr2:99224998 C/G cg10123293 chr2:99228465 UNC50 0.41 5.35 0.31 1.88e-7 Bipolar disorder; CESC cis rs3204270 0.639 rs11867543 chr17:79655046 C/T cg26965718 chr17:79658957 HGS -0.8 -5.91 -0.34 1.04e-8 Dental caries; CESC cis rs2832191 0.791 rs9983651 chr21:30491227 T/A cg24692254 chr21:30365293 RNF160 -0.79 -12.11 -0.6 3.54e-27 Dental caries; CESC cis rs6502050 0.799 rs11491185 chr17:80151101 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.59e-10 Life satisfaction; CESC cis rs362272 0.525 rs910568 chr4:3307373 A/G cg14583973 chr4:3374767 RGS12 0.31 5.19 0.3 4.19e-7 Serum sulfate level; CESC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg12463550 chr7:65579703 CRCP -0.5 -6.34 -0.36 9.71e-10 Aortic root size; CESC cis rs11711311 0.866 rs13313893 chr3:113400856 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.58 7.39 0.41 1.95e-12 IgG glycosylation; CESC cis rs793571 0.523 rs7163162 chr15:58983588 T/A cg05156742 chr15:59063176 FAM63B 0.58 7.87 0.44 9.28e-14 Schizophrenia; CESC cis rs7089973 0.604 rs17663670 chr10:116596269 A/C cg25233709 chr10:116636983 FAM160B1 -0.37 -5.91 -0.34 1.07e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1538970 0.962 rs2487442 chr1:45857176 C/G cg24296786 chr1:45957014 TESK2 0.43 5.14 0.3 5.26e-7 Platelet count; CESC cis rs6426558 0.537 rs2492630 chr1:227286931 A/G cg10327440 chr1:227177885 CDC42BPA 0.47 5.76 0.33 2.3e-8 Neutrophil percentage of white cells; CESC cis rs2404602 0.552 rs11630185 chr15:76959783 A/T cg00316803 chr15:76480434 C15orf27 0.43 5.73 0.33 2.75e-8 Blood metabolite levels; CESC cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg05283184 chr6:79620031 NA -0.43 -6.61 -0.38 2.06e-10 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14532426 chr21:33245908 HUNK 0.6 6.5 0.37 4e-10 Gut microbiome composition (summer); CESC cis rs2777491 1.000 rs316605 chr15:41771591 G/A cg18705301 chr15:41695430 NDUFAF1 -0.64 -9.87 -0.52 9.37e-20 Ulcerative colitis; CESC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg19748678 chr4:122722346 EXOSC9 0.78 9.69 0.51 3.39e-19 Type 2 diabetes; CESC cis rs6121246 0.908 rs6089094 chr20:30431771 C/T cg13852791 chr20:30311386 BCL2L1 0.7 7.24 0.41 4.82e-12 Mean corpuscular hemoglobin; CESC cis rs4268898 0.931 rs2551121 chr2:24539967 T/C cg08917208 chr2:24149416 ATAD2B 0.46 5.23 0.31 3.39e-7 Asthma; CESC cis rs2050392 0.517 rs602097 chr10:30747546 C/T cg18806716 chr10:30721971 MAP3K8 -0.5 -7.68 -0.43 3.08e-13 Inflammatory bowel disease; CESC cis rs9911578 1.000 rs391370 chr17:56675050 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.22 0.31 3.55e-7 Intelligence (multi-trait analysis); CESC cis rs897080 0.552 rs1085443 chr2:44635015 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs9814567 0.806 rs4074521 chr3:134325536 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.42 5.52 0.32 8.16e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9581857 0.685 rs17808758 chr13:28036412 C/T cg01674679 chr13:27998804 GTF3A -0.65 -5.24 -0.31 3.34e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs6541297 0.653 rs4846917 chr1:230299222 T/C cg20703242 chr1:230279135 GALNT2 0.4 6.01 0.35 6.26e-9 Coronary artery disease; CESC cis rs6674176 0.597 rs2352990 chr1:44393276 T/A cg13606994 chr1:44402422 ARTN -0.42 -6.34 -0.36 1.01e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7520050 0.966 rs1707321 chr1:46505309 A/G cg24296786 chr1:45957014 TESK2 0.4 5.07 0.3 7.61e-7 Red blood cell count;Reticulocyte count; CESC cis rs1642645 0.831 rs2042064 chr1:42491429 C/T cg16685388 chr1:42384056 HIVEP3 0.37 5.61 0.33 5.2e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs7100689 0.622 rs7090351 chr10:82142047 T/G cg00277334 chr10:82204260 NA -0.59 -7.73 -0.43 2.25e-13 Post bronchodilator FEV1; CESC cis rs1003719 0.788 rs4817844 chr21:38447064 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.39 -0.46 2.93e-15 Eye color traits; CESC cis rs7584330 0.736 rs6431541 chr2:238376190 A/T cg14458575 chr2:238380390 NA 0.6 8.65 0.47 5.05e-16 Prostate cancer; CESC cis rs12220238 1.000 rs11000900 chr10:75918440 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.63 6.2 0.36 2.13e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs10206020 0.921 rs72776300 chr2:1571152 A/G cg12573674 chr2:1569213 NA -0.47 -5.35 -0.31 1.93e-7 IgG glycosylation; CESC cis rs61931739 0.534 rs10844774 chr12:34166764 C/T cg19457237 chr12:34500585 NA -0.39 -5.33 -0.31 2.08e-7 Morning vs. evening chronotype; CESC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.9 9.42 0.5 2.25e-18 Platelet count; CESC cis rs734999 0.545 rs10910105 chr1:2538209 G/A cg18854424 chr1:2615690 NA 0.3 5.83 0.34 1.65e-8 Ulcerative colitis; CESC cis rs17666538 0.710 rs11987001 chr8:630755 T/C cg13264159 chr8:625131 ERICH1 -0.72 -5.37 -0.31 1.7e-7 IgG glycosylation; CESC cis rs11864453 0.647 rs9932062 chr16:72136055 T/C cg01557791 chr16:72042693 DHODH -0.43 -5.63 -0.33 4.58e-8 Fibrinogen levels; CESC cis rs11997175 0.692 rs6468202 chr8:33747720 C/A ch.8.33884649F chr8:33765107 NA 0.56 6.96 0.39 2.73e-11 Body mass index; CESC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.53 -7.68 -0.43 3.04e-13 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00069017 chr1:6051640 NPHP4 -0.53 -6.52 -0.37 3.56e-10 Ulcerative colitis; CESC cis rs7927771 1.000 rs12419692 chr11:47624714 A/C cg20307385 chr11:47447363 PSMC3 0.48 5.94 0.34 9.14e-9 Subjective well-being; CESC cis rs1059312 0.932 rs4760593 chr12:129287220 A/G cg09035930 chr12:129282057 SLC15A4 0.76 10.59 0.55 4.31e-22 Systemic lupus erythematosus; CESC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg15782153 chr7:917662 C7orf20 0.52 5.72 0.33 2.91e-8 Cerebrospinal P-tau181p levels; CESC cis rs6594499 0.843 rs1993465 chr5:110433098 A/G cg04022379 chr5:110408740 TSLP 0.33 5.95 0.34 8.31e-9 Allergic disease (asthma, hay fever or eczema); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg12737801 chr8:54934346 TCEA1 -0.46 -6.58 -0.37 2.56e-10 Vertical cup-disc ratio; CESC cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg17143192 chr8:8559678 CLDN23 0.74 8.68 0.47 4.19e-16 Obesity-related traits; CESC cis rs2758596 0.850 rs2241110 chr1:156172487 A/G cg25208724 chr1:156163844 SLC25A44 0.66 6.6 0.38 2.24e-10 Paclitaxel disposition in epithelial ovarian cancer; CESC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg21782813 chr7:2030301 MAD1L1 -0.51 -7.3 -0.41 3.45e-12 Bipolar disorder and schizophrenia; CESC cis rs515186 1 rs515186 chr6:36397492 T/G cg04289385 chr6:36355825 ETV7 0.38 5.57 0.32 6.41e-8 Mean platelet volume; CESC cis rs763121 0.853 rs2281020 chr22:39064406 A/G cg14440974 chr22:39074834 NA -0.42 -5.82 -0.34 1.69e-8 Menopause (age at onset); CESC cis rs2011503 1.000 rs78010159 chr19:19615905 C/T cg11584989 chr19:19387371 SF4 0.62 7.13 0.4 9.66e-12 Bipolar disorder; CESC cis rs965469 0.779 rs6133034 chr20:3337661 A/G cg25506879 chr20:3388711 C20orf194 -0.47 -5.07 -0.3 7.62e-7 IFN-related cytopenia; CESC cis rs739401 0.572 rs739400 chr11:3016520 G/A cg25174290 chr11:3078921 CARS 0.51 7.0 0.4 2.1e-11 Longevity; CESC cis rs367943 1.000 rs348941 chr5:112824166 G/C cg12552261 chr5:112820674 MCC -0.63 -7.8 -0.43 1.39e-13 Type 2 diabetes; CESC cis rs7264396 0.563 rs2425086 chr20:34302873 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.64 -0.55 3.06e-22 Total cholesterol levels; CESC cis rs11098499 0.863 rs2291185 chr4:120434833 C/A cg09307838 chr4:120376055 NA 0.93 12.75 0.62 2.41e-29 Corneal astigmatism; CESC cis rs1551570 0.819 rs11666402 chr19:10219076 A/G cg16327482 chr19:10226339 EIF3G 0.43 7.12 0.4 1.03e-11 Narcolepsy; CESC cis rs950776 0.518 rs56007453 chr15:78826239 T/C cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.1 -0.3 6.36e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs6582630 0.500 rs35251810 chr12:38577666 T/C cg26384229 chr12:38710491 ALG10B -0.43 -5.67 -0.33 3.81e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs7726839 0.574 rs11739866 chr5:636299 C/T cg16447950 chr5:562315 NA -0.56 -5.72 -0.33 2.9e-8 Obesity-related traits; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09292873 chr10:111683347 XPNPEP1 -0.44 -6.22 -0.36 1.93e-9 Ulcerative colitis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23814154 chr12:51611356 POU6F1 -0.48 -6.41 -0.37 6.59e-10 Asthma; CESC cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg11952622 chr19:58962976 ZNF324B 0.46 6.33 0.36 1.05e-9 Uric acid clearance; CESC cis rs4243830 1.000 rs10158949 chr1:6583701 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.71 -5.44 -0.32 1.18e-7 Body mass index; CESC cis rs7917772 0.560 rs729023 chr10:104341887 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -5.83 -0.34 1.63e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs60843830 1.000 rs79716074 chr2:277003 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.31 0.53 3.66e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.85 0.34 1.45e-8 Bipolar disorder; CESC cis rs11264213 0.786 rs72659674 chr1:36243012 T/C cg27506609 chr1:36549197 TEKT2 0.65 5.34 0.31 1.97e-7 Schizophrenia; CESC cis rs1801251 1.000 rs35212961 chr2:233582762 C/T cg25237894 chr2:233734115 C2orf82 0.5 8.34 0.46 4.03e-15 Coronary artery disease; CESC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg15283212 chr18:21014021 C18orf45 -0.37 -6.04 -0.35 5.28e-9 Tuberculosis; CESC cis rs4803468 1.000 rs8105833 chr19:41896145 G/A cg09537434 chr19:41945824 ATP5SL -1.02 -18.15 -0.74 2.21e-48 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04347867 chr16:56965804 HERPUD1 0.64 7.69 0.43 2.94e-13 Gut microbiome composition (summer); CESC cis rs1707322 0.752 rs12027622 chr1:46130252 A/C cg06784218 chr1:46089804 CCDC17 0.41 7.12 0.4 1.04e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8067354 0.872 rs2645466 chr17:57853214 A/C cg02344993 chr17:57696989 CLTC 0.49 6.51 0.37 3.7e-10 Hemoglobin concentration; CESC cis rs1878931 0.668 rs2074366 chr16:3439676 G/A cg00484396 chr16:3507460 NAT15 -0.41 -6.37 -0.36 8.54e-10 Body mass index (adult); CESC cis rs67478160 0.634 rs1955660 chr14:104229985 C/T cg08213375 chr14:104286397 PPP1R13B 0.46 9.05 0.49 3.28e-17 Schizophrenia; CESC cis rs1975974 1.000 rs72842072 chr17:21730703 G/A cg18423549 chr17:21743878 NA -0.54 -7.65 -0.43 3.81e-13 Psoriasis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16029321 chr19:14544044 PKN1 -0.48 -6.31 -0.36 1.16e-9 Fibrinogen levels; CESC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg13047869 chr3:10149882 C3orf24 0.4 5.03 0.3 8.89e-7 Alzheimer's disease; CESC cis rs4689388 0.581 rs11727100 chr4:6281458 A/C cg25554036 chr4:6271136 WFS1 0.52 6.56 0.37 2.86e-10 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1023500 0.596 rs5751204 chr22:42433801 C/T cg04733989 chr22:42467013 NAGA 0.77 10.68 0.55 2.3e-22 Schizophrenia; CESC cis rs6460942 0.908 rs967126 chr7:12237300 G/C cg06484146 chr7:12443880 VWDE -0.46 -5.19 -0.3 4.21e-7 Coronary artery disease; CESC trans rs6951245 0.554 rs2070118 chr7:1132505 G/A cg13565492 chr6:43139072 SRF -0.71 -8.22 -0.45 9.35e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11809180 0.546 rs12059132 chr1:169401824 G/A cg09363564 chr1:169337483 NME7;BLZF1 -1.15 -6.84 -0.39 5.62e-11 Electrocardiographic traits; CESC trans rs11039798 0.588 rs7116858 chr11:48543920 C/A cg03929089 chr4:120376271 NA 0.61 6.08 0.35 4.16e-9 Axial length; CESC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg17949981 chr6:28129498 ZNF389 0.43 5.46 0.32 1.09e-7 Parkinson's disease; CESC trans rs72766638 0.848 rs11789898 chr9:136925663 A/C cg09836344 chr4:1243392 C4orf42;CTBP1 0.59 6.09 0.35 4.04e-9 Mosquito bite size; CESC cis rs7216064 0.813 rs12601919 chr17:65825374 A/G cg12091567 chr17:66097778 LOC651250 -0.87 -8.62 -0.47 6.33e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13703070 chr9:102583386 NR4A3 0.46 6.54 0.37 3.18e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg27261378 chr19:44079792 XRCC1 0.55 6.22 0.36 1.89e-9 Psoriatic arthritis; CESC cis rs7267979 0.932 rs417130 chr20:25458320 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.73 13.31 0.63 2.6e-31 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00072720 chr17:7165831 CLDN7 -0.47 -6.2 -0.36 2.13e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.6 5.12 0.3 5.74e-7 LDL cholesterol;Cholesterol, total; CESC cis rs965469 0.843 rs6139122 chr20:3395871 T/G cg25506879 chr20:3388711 C20orf194 -0.64 -6.62 -0.38 2.01e-10 IFN-related cytopenia; CESC cis rs6952808 0.931 rs12537430 chr7:1868761 A/G cg22963979 chr7:1858916 MAD1L1 0.41 5.68 0.33 3.62e-8 Bipolar disorder and schizophrenia; CESC cis rs7084402 0.935 rs10740731 chr10:60348886 G/A cg07615347 chr10:60278583 BICC1 0.54 8.32 0.46 4.65e-15 Refractive error; CESC cis rs2439831 1.000 rs689826 chr15:43749916 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.47 0.54 1.11e-21 Lung cancer in ever smokers; CESC cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg17775713 chr3:133465469 TF 0.32 5.67 0.33 3.69e-8 Iron status biomarkers (transferrin levels); CESC cis rs62064224 0.533 rs11657826 chr17:30790386 T/A cg18200150 chr17:30822561 MYO1D 0.72 11.36 0.57 1.29e-24 Schizophrenia; CESC cis rs7914558 0.966 rs10748837 chr10:104880236 T/C cg04362960 chr10:104952993 NT5C2 0.46 5.92 0.34 9.98e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs826838 0.935 rs1601579 chr12:39178606 G/C cg13010199 chr12:38710504 ALG10B 0.58 8.08 0.44 2.36e-14 Heart rate; CESC cis rs933688 0.938 rs7705465 chr5:90680949 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.87 0.59 2.36e-26 Smoking behavior; CESC trans rs561341 0.709 rs11542477 chr17:30185892 A/G cg20587970 chr11:113659929 NA 1.03 11.3 0.57 1.98e-24 Hip circumference adjusted for BMI; CESC cis rs1348850 0.668 rs4893971 chr2:178495743 T/C cg23306229 chr2:178417860 TTC30B 0.55 6.63 0.38 1.89e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg22800045 chr5:56110881 MAP3K1 0.84 10.36 0.54 2.46e-21 Initial pursuit acceleration; CESC cis rs72772090 0.539 rs72773947 chr5:96125533 T/A cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.26 -0.31 3.01e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9611565 0.592 rs5758405 chr22:42076381 C/A cg17376030 chr22:41985996 PMM1 -0.67 -7.42 -0.41 1.63e-12 Vitiligo; CESC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg18305652 chr10:134549665 INPP5A 0.46 6.35 0.36 9.4e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9486719 1.000 rs12208124 chr6:97027942 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.36 -0.46 3.69e-15 Migraine;Coronary artery disease; CESC cis rs9584850 0.834 rs2031239 chr13:99111560 C/T cg22223119 chr13:99095684 FARP1 -0.36 -5.12 -0.3 5.96e-7 Neuroticism; CESC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg11987759 chr7:65425863 GUSB -0.48 -6.62 -0.38 1.93e-10 Calcium levels; CESC cis rs4268898 0.931 rs60716082 chr2:24526265 T/A cg20701182 chr2:24300061 SF3B14 0.48 5.78 0.33 2.14e-8 Asthma; CESC cis rs9815354 0.857 rs12108064 chr3:42016217 C/T cg03022575 chr3:42003672 ULK4 0.62 6.55 0.37 2.97e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs4835473 0.900 rs6537223 chr4:144892694 T/C cg25736465 chr4:144833511 NA 0.39 6.0 0.35 6.45e-9 Immature fraction of reticulocytes; CESC cis rs9911578 1.000 rs4793950 chr17:56593111 T/C cg05425664 chr17:57184151 TRIM37 0.5 7.0 0.4 2.1e-11 Intelligence (multi-trait analysis); CESC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 14.01 0.65 9.46e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs62064224 0.533 rs11657826 chr17:30790386 T/A cg09324608 chr17:30823087 MYO1D 0.53 8.17 0.45 1.27e-14 Schizophrenia; CESC cis rs9611565 0.694 rs4822032 chr22:41925535 T/C cg03806693 chr22:41940476 POLR3H -0.8 -10.25 -0.53 5.35e-21 Vitiligo; CESC cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg03467027 chr4:99064603 C4orf37 0.48 5.98 0.35 7.02e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9287719 0.967 rs4405729 chr2:10755779 A/G cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg17949981 chr6:28129498 ZNF389 0.46 5.4 0.32 1.45e-7 Parkinson's disease; CESC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.7 6.21 0.36 2.04e-9 Platelet count; CESC cis rs11650494 0.710 rs61427980 chr17:47473580 A/G cg08112188 chr17:47440006 ZNF652 0.83 6.31 0.36 1.17e-9 Prostate cancer; CESC cis rs9291683 0.588 rs3733586 chr4:9997534 C/T cg02734326 chr4:10020555 SLC2A9 0.48 6.91 0.39 3.56e-11 Bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21337984 chr17:6544054 TXNDC17;KIAA0753 -0.43 -6.25 -0.36 1.61e-9 Gambling; CESC cis rs4654899 0.758 rs6688147 chr1:21335894 A/G cg05370193 chr1:21551575 ECE1 0.38 5.84 0.34 1.55e-8 Superior frontal gyrus grey matter volume; CESC cis rs8114671 0.562 rs3746450 chr20:33508588 G/T cg24642439 chr20:33292090 TP53INP2 0.44 5.32 0.31 2.18e-7 Height; CESC cis rs6942407 0.546 rs2108271 chr7:86805372 G/A cg02420886 chr7:86849541 C7orf23 0.52 5.04 0.3 8.76e-7 Food allergy; CESC cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.51 8.78 0.47 2.08e-16 Monocyte percentage of white cells; CESC cis rs7116495 1.000 rs677279 chr11:71770469 G/A cg26138937 chr11:71823887 C11orf51 -0.83 -6.95 -0.39 2.81e-11 Severe influenza A (H1N1) infection; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg07630564 chr3:128445061 RAB7A 0.47 6.07 0.35 4.47e-9 Breast cancer;Type 2 diabetes; CESC cis rs478304 0.934 rs474483 chr11:65520060 T/G cg08755490 chr11:65554678 OVOL1 0.49 6.5 0.37 3.95e-10 Acne (severe); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26631144 chr8:30670260 PPP2CB -0.43 -6.37 -0.36 8.13e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6460942 0.915 rs2216051 chr7:12304054 G/A cg20607287 chr7:12443886 VWDE -0.41 -5.94 -0.34 8.83e-9 Coronary artery disease; CESC cis rs9611565 0.649 rs2413659 chr22:42164862 A/G cg06634786 chr22:41940651 POLR3H 0.48 5.38 0.31 1.62e-7 Vitiligo; CESC cis rs116095464 0.558 rs10057626 chr5:239720 T/G cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.31 0.31 2.3e-7 Breast cancer; CESC cis rs68170813 0.559 rs61406169 chr7:106903421 A/T cg02696742 chr7:106810147 HBP1 -0.54 -5.33 -0.31 2.15e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00688900 chr17:34901364 GGNBP2 -0.61 -7.31 -0.41 3.12e-12 Gut microbiome composition (summer); CESC cis rs4974559 0.641 rs28647383 chr4:1312908 G/C cg02980000 chr4:1222292 CTBP1 0.8 7.27 0.41 3.93e-12 Systolic blood pressure; CESC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg23034840 chr1:205782522 SLC41A1 0.67 8.16 0.45 1.4e-14 Menarche (age at onset); CESC cis rs7590368 0.774 rs3932106 chr2:10916408 C/T cg15705551 chr2:10952987 PDIA6 0.49 5.34 0.31 2.04e-7 Educational attainment (years of education); CESC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.59 0.38 2.35e-10 Bipolar disorder; CESC cis rs2404602 0.692 rs66866130 chr15:77128574 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.07 -0.3 7.56e-7 Blood metabolite levels; CESC cis rs7772486 0.875 rs11155452 chr6:146424631 C/T cg05347473 chr6:146136440 FBXO30 0.51 6.68 0.38 1.37e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4423214 1.000 rs11233746 chr11:71171440 A/G cg24826892 chr11:71159390 DHCR7 0.47 5.18 0.3 4.45e-7 Vitamin D levels; CESC cis rs116095464 0.558 rs7356535 chr5:284117 G/T cg22496380 chr5:211416 CCDC127 -0.99 -10.19 -0.53 8.71e-21 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02696742 chr7:106810147 HBP1 0.58 6.41 0.37 6.63e-10 Gut microbiome composition (summer); CESC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.59 0.38 2.33e-10 Bipolar disorder; CESC cis rs2412459 1.000 rs8023482 chr15:40307095 A/C cg16127683 chr15:40268777 EIF2AK4 -0.6 -6.01 -0.35 6.01e-9 Response to haloperidol in psychosis; CESC cis rs12142240 0.730 rs56030283 chr1:46823093 C/G cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs6570726 0.905 rs430248 chr6:145874104 A/G cg23711669 chr6:146136114 FBXO30 0.8 11.83 0.59 3.33e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg25517755 chr10:38738941 LOC399744 -0.47 -6.04 -0.35 5.28e-9 Extrinsic epigenetic age acceleration; CESC cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg12826209 chr6:26865740 GUSBL1 0.73 8.13 0.45 1.7e-14 Intelligence (multi-trait analysis); CESC cis rs6831352 0.918 rs17218288 chr4:100058030 A/T cg12011299 chr4:100065546 ADH4 -0.59 -6.53 -0.37 3.26e-10 Alcohol dependence; CESC cis rs2839186 0.868 rs2839199 chr21:47708269 T/C cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 7.02e-11 Testicular germ cell tumor; CESC cis rs992157 0.643 rs10191283 chr2:219056755 G/A cg00012203 chr2:219082015 ARPC2 0.86 12.5 0.61 1.74e-28 Colorectal cancer; CESC cis rs2228479 1.000 rs117406136 chr16:89974605 C/T cg00800038 chr16:89945340 TCF25 -0.93 -7.69 -0.43 2.9e-13 Skin colour saturation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06697439 chr19:59031463 ZBTB45 0.39 6.14 0.35 3e-9 Gambling; CESC cis rs4654899 0.758 rs6697284 chr1:21295599 G/A cg05370193 chr1:21551575 ECE1 0.37 5.62 0.33 4.79e-8 Superior frontal gyrus grey matter volume; CESC cis rs2380220 0.541 rs9285413 chr6:96023439 G/A cg23517279 chr6:96025343 MANEA 0.55 5.41 0.32 1.41e-7 Behavioural disinhibition (generation interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02884588 chr19:539155 CDC34 0.45 6.09 0.35 4e-9 Fibrinogen levels; CESC cis rs6732160 0.564 rs7605716 chr2:73376250 G/A cg01422370 chr2:73384389 NA 0.57 9.1 0.49 2.21e-17 Intelligence (multi-trait analysis); CESC trans rs60843830 1.000 rs56167434 chr2:282137 G/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.69 8.5 0.46 1.37e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4974559 0.690 rs28641665 chr4:1288781 G/T cg02980000 chr4:1222292 CTBP1 0.81 7.39 0.41 1.88e-12 Systolic blood pressure; CESC cis rs3892630 0.824 rs34748593 chr19:33240447 T/C cg22980127 chr19:33182716 NUDT19 1.03 11.34 0.57 1.42e-24 Red blood cell traits; CESC cis rs734999 0.545 rs28568531 chr1:2555640 T/A cg18854424 chr1:2615690 NA 0.32 6.18 0.35 2.46e-9 Ulcerative colitis; CESC cis rs11122272 0.701 rs2011383 chr1:231479788 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.23 -0.41 5.18e-12 Hemoglobin concentration; CESC cis rs909002 0.800 rs3753612 chr1:32082410 C/G cg13919466 chr1:32135498 COL16A1 -0.46 -8.26 -0.45 6.82e-15 Intelligence (multi-trait analysis); CESC cis rs7666738 0.791 rs2081621 chr4:98926753 C/A cg03467027 chr4:99064603 C4orf37 0.46 5.56 0.32 6.63e-8 Colonoscopy-negative controls vs population controls; CESC cis rs3845702 0.736 rs2367990 chr2:180843126 C/T cg01881094 chr2:180872142 CWC22 -1.02 -9.36 -0.5 3.69e-18 Schizophrenia; CESC cis rs734999 0.566 rs6424092 chr1:2532899 C/A cg18854424 chr1:2615690 NA -0.28 -5.41 -0.32 1.43e-7 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19120073 chr13:114165365 TMCO3 0.47 6.47 0.37 4.84e-10 Fibrinogen levels; CESC cis rs9300255 0.664 rs28636834 chr12:123871070 A/C cg00376283 chr12:123451042 ABCB9 -0.58 -6.49 -0.37 4.27e-10 Neutrophil percentage of white cells; CESC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.82e-40 Aortic root size; CESC cis rs11958404 0.932 rs6894528 chr5:157434788 A/G cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs12155623 0.932 rs34236473 chr8:49828725 A/T cg22283653 chr8:49824208 NA 0.38 5.83 0.34 1.6e-8 Sudden cardiac arrest; CESC cis rs12464483 0.591 rs67686878 chr2:30895044 C/T cg17749961 chr2:30669863 LCLAT1 0.66 6.71 0.38 1.18e-10 Pre-treatment pain in head and neck squamous cell carcinoma; CESC cis rs3820068 0.581 rs72645881 chr1:15928203 C/T cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs72781680 1.000 rs72796388 chr2:24171509 A/C cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs9457247 0.508 rs9457268 chr6:167503639 A/T cg23791538 chr6:167370224 RNASET2 -0.45 -5.89 -0.34 1.2e-8 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16003274 chr5:139944379 APBB3;SLC35A4 0.56 6.33 0.36 1.03e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.54 7.12 0.4 9.84e-12 Prudent dietary pattern; CESC cis rs5758659 0.569 rs133294 chr22:42382805 C/T cg19513890 chr22:42538836 CYP2D7P1 -0.39 -5.39 -0.31 1.56e-7 Cognitive function; CESC cis rs6570726 0.902 rs406979 chr6:145838983 G/T cg05347473 chr6:146136440 FBXO30 0.44 5.99 0.35 6.71e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs2290159 0.752 rs73130368 chr3:12667374 C/T cg23032965 chr3:12705835 RAF1 0.53 5.68 0.33 3.63e-8 Cholesterol, total; CESC cis rs9837602 0.529 rs793494 chr3:99508768 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.51 -6.25 -0.36 1.65e-9 Breast cancer; CESC cis rs7274811 0.711 rs291691 chr20:32002878 G/C cg21523528 chr20:32077966 CBFA2T2 -0.47 -5.44 -0.32 1.22e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06659009 chr4:95129138 SMARCAD1 0.66 7.16 0.4 8.03e-12 Gut microbiome composition (summer); CESC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg03396347 chr1:1875803 NA -0.46 -7.22 -0.41 5.58e-12 Body mass index; CESC cis rs10751667 0.643 rs7396623 chr11:934104 G/A cg01483505 chr11:975446 AP2A2 0.37 5.03 0.3 8.9e-7 Alzheimer's disease (late onset); CESC trans rs1814175 0.817 rs12287396 chr11:49819798 G/C cg03929089 chr4:120376271 NA -0.91 -15.23 -0.68 4.84e-38 Height; CESC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.62 8.39 0.46 2.99e-15 Menopause (age at onset); CESC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg18252515 chr7:66147081 NA -0.43 -5.55 -0.32 6.78e-8 Aortic root size; CESC cis rs16858210 0.607 rs57874587 chr3:183584749 C/T cg25686905 chr3:183603175 PARL -0.33 -5.72 -0.33 2.8e-8 Menopause (age at onset); CESC cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg19077165 chr18:44547161 KATNAL2 -0.63 -9.53 -0.51 1.07e-18 Personality dimensions; CESC cis rs807669 0.548 rs5746685 chr22:19192596 C/G cg02655711 chr22:19163373 SLC25A1 -0.67 -9.11 -0.49 2.07e-17 Metabolite levels; CESC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg21251018 chr6:28226885 NKAPL 0.33 5.22 0.31 3.6e-7 Cardiac Troponin-T levels; CESC cis rs4253772 0.637 rs9627350 chr22:46663017 A/G cg09491104 chr22:46646882 C22orf40 -0.57 -8.65 -0.47 5.08e-16 LDL cholesterol;Cholesterol, total; CESC cis rs8017423 0.935 rs11624246 chr14:90734826 A/G cg14092571 chr14:90743983 NA 0.56 8.58 0.47 8.26e-16 Mortality in heart failure; CESC cis rs1801251 0.896 rs2197563 chr2:233687080 G/A cg25237894 chr2:233734115 C2orf82 -0.36 -6.51 -0.37 3.81e-10 Coronary artery disease; CESC trans rs79976124 0.879 rs77185357 chr6:66629070 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 8.09 0.45 2.16e-14 Type 2 diabetes; CESC cis rs7707921 0.522 rs4703537 chr5:81480371 C/T cg15871215 chr5:81402204 ATG10 0.48 6.9 0.39 3.84e-11 Breast cancer; CESC cis rs3008870 0.727 rs4582760 chr1:67464394 G/A cg02640540 chr1:67518911 SLC35D1 -0.45 -5.49 -0.32 9.38e-8 Lymphocyte percentage of white cells; CESC trans rs1945213 0.659 rs2086558 chr11:55844453 T/G cg15704280 chr7:45808275 SEPT13 0.76 7.31 0.41 3.15e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs1018697 0.518 rs2482506 chr10:104563743 C/G cg04362960 chr10:104952993 NT5C2 -0.55 -6.24 -0.36 1.7e-9 Colorectal adenoma (advanced); CESC cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg01475377 chr6:109611718 NA -0.42 -6.4 -0.37 6.83e-10 Reticulocyte fraction of red cells; CESC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg06873352 chr17:61820015 STRADA 0.71 12.33 0.6 6.72e-28 Prudent dietary pattern; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04367680 chr8:74005697 C8orf84 0.44 6.24 0.36 1.73e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs763121 0.853 rs2267394 chr22:39101633 T/C cg06544989 chr22:39130855 UNC84B 0.51 9.58 0.51 7.49e-19 Menopause (age at onset); CESC cis rs9467711 0.606 rs9348712 chr6:26366511 T/A cg14345882 chr6:26364793 BTN3A2 0.6 6.17 0.35 2.57e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9916302 0.904 rs4511574 chr17:37532916 A/G cg07936489 chr17:37558343 FBXL20 -0.81 -11.53 -0.58 3.48e-25 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26663754 chr7:93633843 BET1 0.59 6.17 0.35 2.55e-9 Gut microbiome composition (summer); CESC trans rs561341 1.000 rs117979353 chr17:30272866 A/G cg27661571 chr11:113659931 NA -0.87 -8.02 -0.44 3.36e-14 Hip circumference adjusted for BMI; CESC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg02951883 chr7:2050386 MAD1L1 -0.44 -5.72 -0.33 2.93e-8 Bipolar disorder and schizophrenia; CESC cis rs992157 0.560 rs12987130 chr2:219104990 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.57 -7.4 -0.41 1.86e-12 Colorectal cancer; CESC cis rs990171 0.607 rs1558642 chr2:102763960 T/G cg22835712 chr2:102737379 NA 0.44 5.9 0.34 1.1e-8 Lymphocyte counts; CESC cis rs3820068 0.581 rs58425551 chr1:15922518 A/G cg17385448 chr1:15911702 AGMAT 0.41 6.7 0.38 1.24e-10 Systolic blood pressure; CESC trans rs3102460 0.618 rs3101469 chr1:244573645 G/C cg01977209 chr2:236293433 NA 0.47 6.23 0.36 1.87e-9 Obesity-related traits; CESC cis rs9948 0.786 rs62156226 chr2:97417108 G/A cg01990225 chr2:97406019 LMAN2L -0.96 -7.6 -0.42 5.16e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg23048001 chr7:2026167 MAD1L1 0.45 5.85 0.34 1.45e-8 Schizophrenia; CESC cis rs9788682 0.747 rs2656074 chr15:78741384 T/C cg24631222 chr15:78858424 CHRNA5 -0.6 -7.09 -0.4 1.21e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs9899728 0.539 rs56267297 chr17:73046996 T/C cg27626185 chr17:73056755 KCTD2 -0.89 -8.06 -0.44 2.6e-14 Alzheimer's disease or small vessel stroke; CESC cis rs3857067 1.000 rs7694631 chr4:95016931 G/C cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg16132339 chr22:24313637 DDTL;DDT 0.42 6.35 0.36 9.52e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9309473 0.632 rs7599076 chr2:73585519 G/T cg20560298 chr2:73613845 ALMS1 -0.5 -6.92 -0.39 3.33e-11 Metabolite levels; CESC cis rs17826219 0.568 rs11658027 chr17:29094882 A/G cg13385521 chr17:29058706 SUZ12P -0.79 -6.48 -0.37 4.5e-10 Body mass index; CESC cis rs7267979 1.000 rs910997 chr20:25267301 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs2380220 0.516 rs7748108 chr6:96008082 T/C cg23517279 chr6:96025343 MANEA 0.54 5.74 0.33 2.57e-8 Behavioural disinhibition (generation interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01522446 chr17:41150340 RPL27 -0.65 -7.54 -0.42 7.33e-13 Gut microbiome composition (summer); CESC cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg20476274 chr7:133979776 SLC35B4 0.64 9.4 0.5 2.76e-18 Mean platelet volume; CESC cis rs1348850 0.651 rs1901826 chr2:178225266 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.75 10.65 0.55 2.75e-22 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11249608 0.789 rs7704963 chr5:178436854 A/G cg01312482 chr5:178451176 ZNF879 -0.39 -5.48 -0.32 9.71e-8 Pubertal anthropometrics; CESC cis rs11112613 0.775 rs10778413 chr12:105962118 G/A cg03607813 chr12:105948248 NA 0.57 6.39 0.37 7.59e-10 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg16545954 chr1:2118288 C1orf86 -0.35 -6.5 -0.37 3.91e-10 Height; CESC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs3780486 0.505 rs959749 chr9:33147858 T/C cg13443165 chr9:33130375 B4GALT1 0.49 7.48 0.42 1.12e-12 IgG glycosylation; CESC cis rs10129255 0.518 rs10136903 chr14:107187105 T/C cg07958169 chr14:107095056 NA -0.55 -8.64 -0.47 5.22e-16 Kawasaki disease; CESC cis rs889398 0.835 rs12925429 chr16:69801539 G/A cg09409435 chr16:70099608 PDXDC2 -0.42 -5.26 -0.31 2.96e-7 Body mass index; CESC cis rs17641971 0.662 rs2385229 chr8:50003869 T/C cg00325661 chr8:49890786 NA 0.37 5.25 0.31 3.11e-7 Blood metabolite levels; CESC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg02725872 chr8:58115012 NA -0.42 -5.72 -0.33 2.88e-8 Developmental language disorder (linguistic errors); CESC cis rs2295499 0.673 rs55641756 chr4:2704621 C/T cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.2 -0.3 3.91e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs13242816 0.881 rs35037267 chr7:116117587 A/T cg04696780 chr7:116139425 CAV2 -0.62 -5.46 -0.32 1.09e-7 P wave duration; CESC cis rs9611565 0.921 rs6002333 chr22:41719469 C/T cg06634786 chr22:41940651 POLR3H -0.63 -6.6 -0.38 2.21e-10 Vitiligo; CESC cis rs1878931 0.697 rs10048148 chr16:3417450 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.97 14.95 0.68 4.56e-37 Body mass index (adult); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16189722 chr7:73668877 RFC2 0.54 6.03 0.35 5.5e-9 Gut microbiome composition (summer); CESC cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg14393609 chr7:65229607 NA -0.42 -5.44 -0.32 1.19e-7 Aortic root size; CESC cis rs9916302 0.904 rs55660616 chr17:37684990 C/A cg15445000 chr17:37608096 MED1 0.42 6.99 0.39 2.21e-11 Glomerular filtration rate (creatinine); CESC cis rs2952156 0.920 rs1476278 chr17:37836243 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.03 -0.3 8.93e-7 Asthma; CESC cis rs6088590 0.931 rs6088624 chr20:33436852 T/A cg24642439 chr20:33292090 TP53INP2 0.82 11.55 0.58 2.93e-25 Coronary artery disease; CESC cis rs8170 0.603 rs10259 chr19:17430915 G/A cg04749549 chr19:17459798 NA -0.34 -5.39 -0.31 1.54e-7 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CESC cis rs6688613 0.685 rs10800276 chr1:166858941 A/G cg07049167 chr1:166818506 POGK -0.51 -6.15 -0.35 2.89e-9 Refractive astigmatism; CESC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.1 -0.35 3.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17401966 0.867 rs10492973 chr1:10398985 T/C cg15208524 chr1:10270712 KIF1B 0.42 5.34 0.31 1.96e-7 Hepatocellular carcinoma; CESC cis rs7927771 1.000 rs10838747 chr11:47716324 G/C cg18512352 chr11:47633146 NA -0.59 -9.38 -0.5 3.13e-18 Subjective well-being; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg05215272 chr17:6899095 ALOX12 0.45 8.78 0.47 2e-16 Tonsillectomy; CESC cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg03433033 chr1:76189801 ACADM 0.6 6.1 0.35 3.77e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.33 0.36 1.01e-9 Bipolar disorder; CESC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.63 5.6 0.33 5.47e-8 Depression; CESC cis rs6460942 0.915 rs62448619 chr7:12457743 C/T cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC cis rs6088590 0.561 rs3891369 chr20:33161127 C/T cg08999081 chr20:33150536 PIGU 0.69 12.25 0.6 1.18e-27 Coronary artery disease; CESC trans rs561341 0.883 rs1034627 chr17:30219569 C/T cg20587970 chr11:113659929 NA -0.92 -11.47 -0.58 5.51e-25 Hip circumference adjusted for BMI; CESC cis rs9354308 0.899 rs2814153 chr6:66557611 T/A cg07460842 chr6:66804631 NA 0.61 6.86 0.39 4.83e-11 Metabolite levels; CESC cis rs1256061 0.624 rs944047 chr14:64700292 C/T cg21174375 chr14:64681225 SYNE2 0.48 6.38 0.36 7.86e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6912958 0.559 rs376633 chr6:88042785 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.74 11.54 0.58 3.24e-25 Monocyte percentage of white cells; CESC cis rs763014 0.865 rs710924 chr16:633353 T/C cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg03172717 chr10:51565268 NCOA4 -0.47 -6.48 -0.37 4.57e-10 Recombination measurement; CESC cis rs3862260 0.509 rs10802124 chr1:120164252 G/A cg11530693 chr1:120165357 ZNF697 0.69 10.58 0.55 4.58e-22 Systemic lupus erythematosus; CESC trans rs1373453 0.731 rs79185255 chr12:70070288 A/G cg19702771 chr4:82058885 PRKG2 0.75 6.12 0.35 3.4e-9 Orofacial clefts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01256882 chr5:1271100 TERT -0.52 -6.61 -0.38 2.12e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC trans rs1559088 0.512 rs34266236 chr19:33564874 C/A cg13714067 chr14:103989336 CKB 0.65 6.07 0.35 4.42e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs62103177 0.810 rs62103191 chr18:77628769 C/G cg12964065 chr18:77638022 KCNG2 0.58 5.46 0.32 1.07e-7 Opioid sensitivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19734257 chr20:56064117 HMGB1L1 -0.59 -7.82 -0.43 1.26e-13 Gut microbiome composition (summer); CESC cis rs8133932 0.654 rs375254 chr21:47337151 T/A cg14185626 chr21:47401492 COL6A1 -0.45 -5.09 -0.3 6.84e-7 Schizophrenia; CESC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.84 0.34 1.51e-8 Tonsillectomy; CESC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg05368731 chr17:41323189 NBR1 0.5 6.86 0.39 4.72e-11 Menopause (age at onset); CESC cis rs6754311 0.773 rs309179 chr2:136613780 G/A cg07169764 chr2:136633963 MCM6 -0.69 -8.56 -0.47 9.42e-16 Mosquito bite size; CESC cis rs6541297 0.703 rs607553 chr1:230316444 T/A cg20703242 chr1:230279135 GALNT2 -0.43 -5.62 -0.33 4.84e-8 Coronary artery disease; CESC cis rs909674 0.690 rs5750825 chr22:39831278 A/G cg24399712 chr22:39784796 NA -0.8 -10.92 -0.56 3.65e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg02487422 chr3:49467188 NICN1 0.41 5.08 0.3 7.03e-7 Parkinson's disease; CESC cis rs3768617 0.811 rs10911200 chr1:182998377 T/C ch.1.3577855R chr1:183094577 LAMC1 0.65 8.83 0.48 1.43e-16 Fuchs's corneal dystrophy; CESC cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg00074818 chr8:8560427 CLDN23 0.38 5.46 0.32 1.1e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06340276 chr4:89204787 PPM1K -0.58 -6.95 -0.39 2.75e-11 Gut microbiome composition (summer); CESC cis rs2074585 0.560 rs1973537 chr15:91062901 T/C cg22089800 chr15:90895588 ZNF774 -0.42 -5.13 -0.3 5.5e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs2404602 0.716 rs2404736 chr15:76875943 T/C cg22467129 chr15:76604101 ETFA -0.35 -5.22 -0.31 3.65e-7 Blood metabolite levels; CESC cis rs1577917 1.000 rs12215903 chr6:86675028 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.92 -0.34 9.76e-9 Response to antipsychotic treatment; CESC cis rs6831352 0.918 rs29001224 chr4:100047373 G/A cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs1153858 1.000 rs4627277 chr15:45652768 C/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.97 0.34 7.62e-9 Homoarginine levels; CESC cis rs8005677 0.828 rs712486 chr14:23425041 A/G cg01529538 chr14:23388837 RBM23 0.44 6.01 0.35 6.28e-9 Cognitive ability (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10462529 chr17:78880748 RPTOR 0.44 6.43 0.37 5.77e-10 Fibrinogen levels; CESC cis rs1018836 0.544 rs2339154 chr8:91459316 T/C cg16814680 chr8:91681699 NA -0.45 -6.0 -0.35 6.43e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs561341 1.000 rs1557731 chr17:30321567 T/G cg27661571 chr11:113659931 NA -0.7 -7.12 -0.4 1.01e-11 Hip circumference adjusted for BMI; CESC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg14393609 chr7:65229607 NA -0.52 -7.07 -0.4 1.36e-11 Calcium levels; CESC cis rs116095464 0.510 rs7723883 chr5:270798 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.28 0.31 2.72e-7 Breast cancer; CESC cis rs1348850 0.651 rs4893936 chr2:178240676 C/G cg23306229 chr2:178417860 TTC30B 0.54 7.01 0.4 1.96e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6570726 1.000 rs455109 chr6:145872665 C/T cg23711669 chr6:146136114 FBXO30 0.77 11.24 0.57 3.15e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg25019033 chr10:957182 NA 0.57 6.12 0.35 3.42e-9 Eosinophil percentage of granulocytes; CESC cis rs2204008 0.806 rs7305409 chr12:38349133 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.62 0.38 2.03e-10 Bladder cancer; CESC cis rs10465746 0.570 rs11163885 chr1:84472956 A/G cg10977910 chr1:84465055 TTLL7 0.44 5.54 0.32 7.2e-8 Obesity-related traits; CESC cis rs3845702 0.668 rs6759271 chr2:180844303 T/C cg01881094 chr2:180872142 CWC22 -1.08 -9.69 -0.51 3.43e-19 Schizophrenia; CESC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg12311346 chr5:56204834 C5orf35 0.72 8.71 0.47 3.44e-16 Initial pursuit acceleration; CESC cis rs9486719 0.857 rs6568392 chr6:96861476 G/T cg18709589 chr6:96969512 KIAA0776 0.43 5.03 0.3 9.2e-7 Migraine;Coronary artery disease; CESC cis rs644799 1.000 rs586238 chr11:95560371 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.56 6.94 0.39 3.08e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1153858 1.000 rs4775906 chr15:45638294 C/T cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg02461776 chr11:598696 PHRF1 0.46 5.11 0.3 6.24e-7 Systemic lupus erythematosus; CESC cis rs68092024 0.704 rs704575 chr3:99486075 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.43 -6.77 -0.38 8.4e-11 Cleft lip with or without cleft palate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06028048 chr5:175815674 HIGD2A;NOP16 -0.46 -6.45 -0.37 5.16e-10 Gambling; CESC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg07157834 chr1:205819609 PM20D1 0.4 5.32 0.31 2.2e-7 Menarche (age at onset); CESC cis rs10129255 0.500 rs8021941 chr14:107189727 C/T cg07958169 chr14:107095056 NA -0.58 -9.41 -0.5 2.53e-18 Kawasaki disease; CESC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.13 -20.95 -0.79 3.91e-58 Prudent dietary pattern; CESC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg24531977 chr5:56204891 C5orf35 -0.49 -5.92 -0.34 9.9e-9 Coronary artery disease; CESC cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -5.87 -0.34 1.3e-8 Mood instability; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg01487461 chr9:2017199 SMARCA2 0.54 7.14 0.4 9.11e-12 Attention deficit hyperactivity disorder; CESC cis rs4132509 0.744 rs10803156 chr1:243917776 G/C cg21452805 chr1:244014465 NA 0.64 7.03 0.4 1.71e-11 RR interval (heart rate); CESC cis rs10779751 1.000 rs7525957 chr1:11318236 C/T cg08854313 chr1:11322531 MTOR 0.84 11.92 0.59 1.57e-26 Body mass index; CESC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg04546413 chr19:29218101 NA 0.56 7.91 0.44 6.84e-14 Methadone dose in opioid dependence; CESC cis rs2066819 1.000 rs2643626 chr12:56726518 C/T cg26714650 chr12:56694279 CS 1.24 15.03 0.68 2.31e-37 Psoriasis vulgaris; CESC cis rs2559856 1.000 rs2695286 chr12:102088507 T/C cg12213457 chr12:102090980 CHPT1 -0.36 -5.33 -0.31 2.07e-7 Blood protein levels; CESC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.26 0.79 3.33e-59 Prudent dietary pattern; CESC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg22903471 chr2:27725779 GCKR -0.5 -7.16 -0.4 7.71e-12 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20020483 chr16:32289928 NA 0.47 6.37 0.36 8.1e-10 Fibrinogen levels; CESC cis rs4315565 0.764 rs11900784 chr2:69272496 A/T cg12800200 chr2:69260302 ANTXR1 0.42 6.01 0.35 5.95e-9 Height; CESC cis rs10465746 0.901 rs17534614 chr1:84383079 G/A cg10977910 chr1:84465055 TTLL7 0.45 6.07 0.35 4.37e-9 Obesity-related traits; CESC cis rs7818345 0.874 rs12674938 chr8:19300813 A/G cg11303988 chr8:19266685 CSGALNACT1 0.34 6.1 0.35 3.74e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs709400 0.628 rs2010281 chr14:103862322 G/A cg12935359 chr14:103987150 CKB -0.52 -7.62 -0.42 4.4e-13 Body mass index; CESC cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg02711726 chr17:80685570 FN3KRP 0.59 8.92 0.48 7.89e-17 Glycated hemoglobin levels; CESC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg22974920 chr21:40686053 BRWD1 -0.47 -5.72 -0.33 2.88e-8 Cognitive function; CESC cis rs9486719 1.000 rs35487471 chr6:96879715 C/T cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs2806561 0.765 rs1997866 chr1:23512524 A/G cg12483005 chr1:23474871 LUZP1 0.39 6.11 0.35 3.63e-9 Height; CESC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg18016565 chr1:150552671 MCL1 0.35 5.18 0.3 4.32e-7 Melanoma; CESC cis rs4523957 0.855 rs1231209 chr17:2124972 G/A cg16513277 chr17:2031491 SMG6 -0.64 -8.84 -0.48 1.36e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9811920 0.931 rs7629487 chr3:99860401 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 6.11 0.35 3.56e-9 Axial length; CESC trans rs11039798 1.000 rs7125559 chr11:48984207 C/G cg15704280 chr7:45808275 SEPT13 0.7 6.52 0.37 3.51e-10 Axial length; CESC cis rs9905704 0.671 rs2531736 chr17:56552204 A/G cg12560992 chr17:57184187 TRIM37 -0.58 -5.45 -0.32 1.17e-7 Testicular germ cell tumor; CESC trans rs13398848 1.000 rs10165993 chr2:84200880 A/G cg23262351 chr6:79576851 IRAK1BP1 -0.68 -6.02 -0.35 5.73e-9 Conduct disorder (symptom count);Conduct disorder; CESC cis rs7654585 1.000 rs4692025 chr4:25949759 A/C cg10409131 chr4:25915609 C4orf52 -0.49 -6.68 -0.38 1.44e-10 Obesity-related traits; CESC cis rs67311347 1.000 rs1004655 chr3:40490009 G/A cg09455208 chr3:40491958 NA 0.52 8.27 0.45 6.69e-15 Renal cell carcinoma; CESC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg07677032 chr17:61819896 STRADA 0.4 5.05 0.3 8.26e-7 Height; CESC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg09359103 chr1:154839909 KCNN3 -0.65 -12.26 -0.6 1.15e-27 Prostate cancer; CESC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.47 -0.32 1.05e-7 Total body bone mineral density; CESC cis rs7818688 0.578 rs73269188 chr8:95838346 C/G cg16049864 chr8:95962084 TP53INP1 0.52 5.48 0.32 9.71e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs34779708 0.931 rs12768019 chr10:35389843 T/C cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6912958 1.000 rs6937823 chr6:88160386 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.35 -5.81 -0.34 1.82e-8 Monocyte percentage of white cells; CESC cis rs9309473 1.000 rs3813227 chr2:73651967 A/G cg20560298 chr2:73613845 ALMS1 0.46 6.27 0.36 1.48e-9 Metabolite levels; CESC cis rs2204008 0.805 rs12146846 chr12:37985847 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.66 0.38 1.61e-10 Bladder cancer; CESC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg02951883 chr7:2050386 MAD1L1 -0.49 -6.51 -0.37 3.8e-10 Bipolar disorder and schizophrenia; CESC cis rs9287719 0.839 rs7600695 chr2:10739945 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs863345 0.604 rs12120526 chr1:158498404 T/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.15e-11 Pneumococcal bacteremia; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg10078639 chr10:116286586 ABLIM1 0.49 6.01 0.35 5.95e-9 Psoriatic arthritis; CESC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg24642844 chr7:1081250 C7orf50 -0.75 -9.1 -0.49 2.29e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08493879 chr7:151722810 GALNT11 0.53 6.22 0.36 1.96e-9 Gut microbiome composition (summer); CESC cis rs425277 0.958 rs262688 chr1:2113565 T/G cg24578937 chr1:2090814 PRKCZ 0.54 9.39 0.5 2.96e-18 Height; CESC cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.9 7.88 0.44 8.53e-14 Initial pursuit acceleration; CESC cis rs9914988 0.725 rs9905510 chr17:27092325 G/A cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs1348850 0.632 rs13008833 chr2:178514439 G/C cg23306229 chr2:178417860 TTC30B 0.6 7.53 0.42 7.75e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs67478160 0.643 rs876002 chr14:104239697 G/A cg08213375 chr14:104286397 PPP1R13B 0.55 11.09 0.56 9.71e-24 Schizophrenia; CESC cis rs2288073 0.965 rs13395596 chr2:24410738 T/C cg06627628 chr2:24431161 ITSN2 -0.73 -8.64 -0.47 5.5e-16 Venous thromboembolism (SNP x SNP interaction); CESC cis rs10992471 0.598 rs10761156 chr9:95171852 C/T cg13798575 chr9:95087839 CENPP;NOL8 0.4 5.04 0.3 8.5e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs7998202 0.667 rs408220 chr13:113370267 T/C cg02820901 chr13:113351484 ATP11A 0.65 5.41 0.32 1.4e-7 Glycated hemoglobin levels; CESC cis rs7216064 1.000 rs62084213 chr17:65842016 A/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.83 -0.48 1.49e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg18230493 chr5:56204884 C5orf35 -0.7 -8.62 -0.47 6.14e-16 Initial pursuit acceleration; CESC cis rs4568518 0.561 rs4579426 chr7:18008259 A/T cg03009463 chr7:17980271 SNX13 0.43 5.73 0.33 2.77e-8 Measles; CESC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg05368731 chr17:41323189 NBR1 0.55 7.6 0.42 5.03e-13 Menopause (age at onset); CESC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Parkinson's disease; CESC cis rs9549367 0.713 rs9549357 chr13:113860121 C/T cg18105134 chr13:113819100 PROZ -0.6 -7.66 -0.43 3.56e-13 Platelet distribution width; CESC cis rs2991971 0.747 rs2492841 chr1:45894891 G/T cg03146154 chr1:46216737 IPP 0.39 5.04 0.3 8.51e-7 High light scatter reticulocyte count; CESC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs9640161 0.750 rs3735173 chr7:150020526 C/T cg10018233 chr7:150070692 REPIN1 0.49 7.87 0.44 8.84e-14 Blood protein levels;Circulating chemerin levels; CESC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg18876405 chr7:65276391 NA -0.53 -7.28 -0.41 3.82e-12 Aortic root size; CESC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg25517755 chr10:38738941 LOC399744 0.45 5.77 0.33 2.19e-8 Extrinsic epigenetic age acceleration; CESC cis rs2239547 0.522 rs2564947 chr3:53046216 C/T cg11645453 chr3:52864694 ITIH4 -0.32 -5.51 -0.32 8.38e-8 Schizophrenia; CESC cis rs6987853 0.563 rs2923408 chr8:42451526 A/G cg09913449 chr8:42400586 C8orf40 0.35 5.56 0.32 6.43e-8 Mean corpuscular hemoglobin concentration; CESC cis rs6088580 0.634 rs6119497 chr20:33012529 T/A cg06115741 chr20:33292138 TP53INP2 0.48 6.13 0.35 3.2e-9 Glomerular filtration rate (creatinine); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08249556 chr21:30365104 RNF160 -0.43 -6.18 -0.35 2.39e-9 Gambling; CESC cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs8060686 0.641 rs113162813 chr16:68038969 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.15 -0.35 2.78e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg19717773 chr7:2847554 GNA12 -0.54 -8.49 -0.46 1.47e-15 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16294016 chr4:190862268 FRG1 0.53 6.06 0.35 4.62e-9 Gut microbiome composition (summer); CESC cis rs1153858 1.000 rs60476496 chr15:45713801 C/T cg14582100 chr15:45693742 SPATA5L1 0.41 5.79 0.33 2.03e-8 Homoarginine levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21725374 chr8:145171334 KIAA1875 0.5 6.98 0.39 2.43e-11 Fibrinogen levels; CESC cis rs17641971 0.684 rs7011891 chr8:49983538 A/C cg00325661 chr8:49890786 NA 0.4 5.58 0.32 5.94e-8 Blood metabolite levels; CESC cis rs2777491 1.000 rs316613 chr15:41747598 G/A cg20272979 chr15:41787780 ITPKA 0.43 6.42 0.37 6.44e-10 Ulcerative colitis; CESC cis rs4853012 1.000 rs2280643 chr2:74358286 T/C cg19729930 chr2:74357872 NA 0.87 12.57 0.61 1e-28 Gestational age at birth (maternal effect); CESC cis rs7560272 0.538 rs35767294 chr2:73922834 A/G cg20560298 chr2:73613845 ALMS1 0.45 6.15 0.35 2.78e-9 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25846302 chr15:102501640 WASH3P -0.51 -6.2 -0.36 2.13e-9 Gut microbiome composition (summer); CESC cis rs2239547 0.618 rs4687663 chr3:52870618 T/A cg11645453 chr3:52864694 ITIH4 0.36 6.55 0.37 2.98e-10 Schizophrenia; CESC cis rs317689 0.819 rs317660 chr12:69686203 G/A cg20891283 chr12:69753455 YEATS4 0.48 5.13 0.3 5.57e-7 Response to diuretic therapy; CESC trans rs561341 0.883 rs7219239 chr17:30212016 A/G cg27661571 chr11:113659931 NA 0.6 6.09 0.35 3.88e-9 Hip circumference adjusted for BMI; CESC cis rs6076065 0.707 rs1419007 chr20:23336895 T/C cg11657817 chr20:23433608 CST11 0.41 6.22 0.36 1.88e-9 Facial morphology (factor 15, philtrum width); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12879381 chr18:12326166 TUBB6 0.45 6.08 0.35 4.15e-9 Fibrinogen levels; CESC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg12963246 chr6:28129442 ZNF389 0.5 6.44 0.37 5.59e-10 Depression; CESC cis rs16867321 0.614 rs10204086 chr2:181449668 G/T cg23363182 chr2:181467187 NA -0.5 -7.42 -0.41 1.63e-12 Obesity; CESC cis rs7085104 0.513 rs192569 chr10:104577915 T/C cg04362960 chr10:104952993 NT5C2 -0.5 -6.83 -0.39 5.95e-11 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs9300255 0.679 rs10846507 chr12:123786492 G/T cg19016782 chr12:123741754 C12orf65 -0.42 -5.82 -0.34 1.7e-8 Neutrophil percentage of white cells; CESC cis rs637571 0.522 rs566590 chr11:65754062 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 6.02 0.35 5.67e-9 Eosinophil percentage of white cells; CESC cis rs10883723 0.810 rs2281879 chr10:104268877 C/G cg22532475 chr10:104410764 TRIM8 -0.35 -5.94 -0.34 9.07e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs9584850 0.834 rs3783005 chr13:99111337 A/T cg22223119 chr13:99095684 FARP1 0.35 5.12 0.3 5.98e-7 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14065121 chr9:77643271 C9orf41 0.61 7.31 0.41 3.17e-12 Gut microbiome composition (summer); CESC cis rs12579753 0.879 rs12579544 chr12:82164043 A/C cg23701643 chr12:82153290 PPFIA2 -0.35 -5.03 -0.3 8.99e-7 Resting heart rate; CESC cis rs3126085 0.877 rs12133847 chr1:152170101 T/G cg26876637 chr1:152193138 HRNR 0.44 5.12 0.3 5.98e-7 Atopic dermatitis; CESC cis rs35955747 0.838 rs5997900 chr22:31580346 C/A cg25791279 chr22:32026902 PISD -0.47 -5.59 -0.32 5.75e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg05872129 chr22:39784769 NA -0.83 -11.04 -0.56 1.48e-23 Intelligence (multi-trait analysis); CESC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg09165964 chr15:75287851 SCAMP5 0.45 6.09 0.35 3.99e-9 Breast cancer; CESC cis rs7107174 1.000 rs58565853 chr11:78036707 C/T cg03754400 chr11:77348600 CLNS1A 0.45 5.11 0.3 6.1e-7 Testicular germ cell tumor; CESC cis rs10857712 1.000 rs10857712 chr10:135225666 T/C cg01444801 chr10:135216882 MTG1 -0.44 -5.23 -0.31 3.43e-7 Systemic lupus erythematosus; CESC cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg04025307 chr7:1156635 C7orf50 0.41 5.75 0.33 2.48e-8 Bronchopulmonary dysplasia; CESC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.65 0.38 1.62e-10 Bipolar disorder; CESC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg24642844 chr7:1081250 C7orf50 -0.63 -8.1 -0.45 2.06e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs72781680 0.566 rs55987381 chr2:23900938 T/C cg08917208 chr2:24149416 ATAD2B 0.76 7.38 0.41 2.03e-12 Lymphocyte counts; CESC cis rs34779708 0.931 rs55724039 chr10:35465397 A/G cg04310649 chr10:35416472 CREM -0.53 -6.49 -0.37 4.32e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05609414 chr7:39873832 NA -0.53 -7.08 -0.4 1.33e-11 Gut microbiome composition (summer); CESC cis rs7772486 0.686 rs9390348 chr6:146044748 C/T cg05347473 chr6:146136440 FBXO30 -0.52 -6.93 -0.39 3.22e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2354432 0.607 rs7537279 chr1:146673642 A/G cg25205988 chr1:146714368 CHD1L 1.19 9.08 0.49 2.58e-17 Mitochondrial DNA levels; CESC cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.47 5.26 0.31 2.95e-7 Osteoporosis; CESC cis rs9905704 0.918 rs36071323 chr17:56916804 C/T cg12560992 chr17:57184187 TRIM37 0.61 7.05 0.4 1.54e-11 Testicular germ cell tumor; CESC trans rs35146811 0.731 rs2257213 chr7:99810113 T/C cg13215871 chr17:75784724 NA -0.35 -6.45 -0.37 5.26e-10 Coronary artery disease; CESC cis rs7474896 0.515 rs2738208 chr10:38306128 A/G cg00409905 chr10:38381863 ZNF37A 0.46 5.15 0.3 5.05e-7 Obesity (extreme); CESC cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09315918 chr1:206137767 FAM72A -0.45 -6.05 -0.35 4.99e-9 Fibrinogen levels; CESC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg24531977 chr5:56204891 C5orf35 -0.66 -9.17 -0.49 1.41e-17 Initial pursuit acceleration; CESC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg24675658 chr1:53192096 ZYG11B 0.53 6.78 0.38 7.96e-11 Monocyte count; CESC cis rs7762018 0.655 rs2184195 chr6:170148397 C/T cg05834625 chr6:170176447 C6orf70 0.65 7.17 0.4 7.57e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9902453 1.000 rs7212497 chr17:28335949 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.6 -7.52 -0.42 8.34e-13 Coffee consumption (cups per day); CESC trans rs7246657 0.943 rs7255785 chr19:37971683 C/T cg24637308 chr11:6592297 DNHD1 0.54 6.24 0.36 1.75e-9 Coronary artery calcification; CESC cis rs3736485 0.966 rs12102203 chr15:51791559 A/G cg08986416 chr15:51914746 DMXL2 -0.4 -5.24 -0.31 3.34e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg25036284 chr2:26402008 FAM59B -0.58 -6.72 -0.38 1.09e-10 Gut microbiome composition (summer); CESC cis rs4925386 0.681 rs2427295 chr20:60927431 G/A cg22633769 chr20:60982531 CABLES2 0.56 5.95 0.34 8.51e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs9443645 0.810 rs10943613 chr6:79745107 C/T cg05283184 chr6:79620031 NA -0.39 -5.96 -0.34 8.04e-9 Intelligence (multi-trait analysis); CESC cis rs1878931 0.858 rs3760083 chr16:3450052 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.95 -14.37 -0.66 5.07e-35 Body mass index (adult); CESC cis rs4594175 0.926 rs7493621 chr14:51623665 C/T cg23942311 chr14:51606299 NA 0.34 5.07 0.3 7.54e-7 Cancer; CESC cis rs6500602 0.592 rs4785966 chr16:4518754 C/T cg08645402 chr16:4508243 NA -0.44 -6.71 -0.38 1.2e-10 Schizophrenia; CESC trans rs2693676 0.504 rs1257490 chr14:99604188 G/A cg17465227 chr4:47427752 GABRB1 0.59 6.35 0.36 9.51e-10 Corneal curvature; CESC cis rs8180040 0.620 rs9858443 chr3:47086048 G/A cg27129171 chr3:47204927 SETD2 0.67 9.83 0.52 1.18e-19 Colorectal cancer; CESC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg18876405 chr7:65276391 NA -0.69 -9.49 -0.5 1.4e-18 Aortic root size; CESC cis rs6496667 0.510 rs16944405 chr15:90975517 A/G cg10434728 chr15:90938212 IQGAP1 0.33 5.59 0.32 5.74e-8 Rheumatoid arthritis; CESC cis rs4953076 0.573 rs6738023 chr2:44405931 T/C cg04920474 chr2:44395004 PPM1B 0.55 7.06 0.4 1.5e-11 Height; CESC cis rs7618501 1.000 rs60205400 chr3:49800272 C/T cg24308560 chr3:49941425 MST1R -0.52 -7.18 -0.4 7.15e-12 Intelligence (multi-trait analysis); CESC cis rs6582630 0.599 rs12309369 chr12:38419683 C/G cg26384229 chr12:38710491 ALG10B -0.41 -5.49 -0.32 9.35e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs34779708 0.931 rs72789690 chr10:35382817 T/C cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs1847505 0.609 rs9539004 chr13:61587049 T/C cg25164009 chr13:61490935 NA -0.41 -5.51 -0.32 8.54e-8 Polychlorinated biphenyl levels; CESC cis rs116095464 0.558 rs10076655 chr5:239464 G/C cg20965017 chr5:231967 SDHA -0.46 -5.23 -0.31 3.51e-7 Breast cancer; CESC trans rs877282 0.898 rs11253344 chr10:765162 C/T cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs17253792 0.822 rs74824071 chr14:56095142 T/G cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs6456156 0.774 rs9347175 chr6:167527644 A/T cg07741184 chr6:167504864 NA -0.31 -5.2 -0.3 4.02e-7 Primary biliary cholangitis; CESC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg03609598 chr5:56110824 MAP3K1 -0.5 -5.4 -0.31 1.48e-7 Initial pursuit acceleration; CESC trans rs61931739 0.534 rs11053073 chr12:34202412 C/T cg26384229 chr12:38710491 ALG10B 0.64 9.15 0.49 1.59e-17 Morning vs. evening chronotype; CESC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg08859206 chr1:53392774 SCP2 0.62 8.96 0.48 6.03e-17 Monocyte count; CESC cis rs7605827 0.930 rs12995845 chr2:15520539 C/T cg19274914 chr2:15703543 NA 0.36 6.48 0.37 4.44e-10 Educational attainment (years of education); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14272860 chr19:42580418 ZNF574 -0.47 -6.48 -0.37 4.33e-10 Fibrinogen levels; CESC cis rs11166629 1.000 rs6992668 chr8:135645129 T/C cg27224718 chr8:135614730 ZFAT 0.52 6.43 0.37 6.03e-10 Smoking quantity; CESC cis rs1153858 1.000 rs7171577 chr15:45627979 G/A cg21132104 chr15:45694354 SPATA5L1 0.84 11.38 0.57 1.09e-24 Homoarginine levels; CESC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.4 0.32 1.45e-7 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00070814 chr10:70715958 DDX21 0.56 6.03 0.35 5.62e-9 Gut microbiome composition (summer); CESC cis rs60154123 0.772 rs628908 chr1:210428002 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.52 5.65 0.33 4.05e-8 Coronary artery disease; CESC cis rs761746 0.739 rs5753691 chr22:31952045 A/G cg25791279 chr22:32026902 PISD 0.64 6.93 0.39 3.11e-11 Intelligence; CESC cis rs3820928 0.605 rs6718767 chr2:227800776 A/G cg05526886 chr2:227700861 RHBDD1 -0.54 -7.4 -0.41 1.8e-12 Pulmonary function; CESC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg02463440 chr8:22132932 PIWIL2 0.39 6.0 0.35 6.34e-9 Hypertriglyceridemia; CESC cis rs7772486 0.875 rs854148 chr6:146310979 G/C cg23711669 chr6:146136114 FBXO30 0.9 13.1 0.63 1.45e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg27121462 chr16:89883253 FANCA -0.46 -5.53 -0.32 7.83e-8 Vitiligo; CESC cis rs3820068 0.529 rs79570154 chr1:15990912 T/C cg16988262 chr1:15930761 NA 0.35 5.61 0.33 5.18e-8 Systolic blood pressure; CESC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg04181038 chr4:183730758 NA 0.59 6.95 0.39 2.79e-11 Pediatric autoimmune diseases; CESC cis rs2479106 0.591 rs879070 chr9:126433214 T/C cg16191174 chr9:126692580 DENND1A 0.4 5.7 0.33 3.21e-8 Polycystic ovary syndrome; CESC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg10295955 chr4:187884368 NA -1.07 -21.51 -0.8 4.72e-60 Lobe attachment (rater-scored or self-reported); CESC cis rs7586879 0.593 rs10198275 chr2:25130542 A/C cg01884057 chr2:25150051 NA 0.36 6.96 0.39 2.66e-11 Body mass index; CESC cis rs734999 0.566 rs4648563 chr1:2536002 C/G cg20673091 chr1:2541236 MMEL1 0.43 7.16 0.4 7.78e-12 Ulcerative colitis; CESC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg22143856 chr6:28129313 ZNF389 0.44 5.82 0.34 1.68e-8 Depression; CESC cis rs208520 0.706 rs851601 chr6:66893853 G/A cg07460842 chr6:66804631 NA -0.93 -11.86 -0.59 2.64e-26 Exhaled nitric oxide output; CESC cis rs6547741 0.967 rs4665999 chr2:27834444 T/C cg27432699 chr2:27873401 GPN1 0.49 6.93 0.39 3.21e-11 Oral cavity cancer; CESC cis rs208520 0.526 rs7771233 chr6:66819784 A/G cg07460842 chr6:66804631 NA -1.04 -22.74 -0.81 3.19e-64 Exhaled nitric oxide output; CESC cis rs611744 0.647 rs676654 chr8:109242303 A/G cg21045802 chr8:109455806 TTC35 0.5 6.23 0.36 1.87e-9 Dupuytren's disease; CESC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg11494091 chr17:61959527 GH2 0.73 12.36 0.6 5.16e-28 Prudent dietary pattern; CESC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -0.91 -13.19 -0.63 7.11e-31 Alzheimer's disease; CESC cis rs2115536 0.640 rs934134 chr15:80168218 T/C cg00225070 chr15:80189496 MTHFS 0.42 5.56 0.32 6.57e-8 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg00149659 chr3:10157352 C3orf10 0.72 8.45 0.46 1.94e-15 Alzheimer's disease; CESC cis rs4304924 0.500 rs9601109 chr13:79220114 A/G cg01819759 chr13:79234251 RNF219 0.41 5.3 0.31 2.4e-7 Large artery stroke; CESC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg16049864 chr8:95962084 TP53INP1 -0.72 -13.04 -0.63 2.36e-30 Type 2 diabetes; CESC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg04267008 chr7:1944627 MAD1L1 -0.44 -5.23 -0.31 3.51e-7 Schizophrenia; CESC cis rs34779708 0.736 rs34195979 chr10:35549817 T/C cg04310649 chr10:35416472 CREM -0.46 -5.22 -0.31 3.55e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg22535103 chr8:58192502 C8orf71 -1.03 -10.96 -0.56 2.68e-23 Developmental language disorder (linguistic errors); CESC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg11644478 chr21:40555479 PSMG1 1.06 17.9 0.74 1.63e-47 Cognitive function; CESC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg24250549 chr1:154909240 PMVK -0.47 -6.23 -0.36 1.82e-9 Prostate cancer; CESC trans rs79349575 0.783 rs1994970 chr17:47014127 C/T cg07977620 chr11:56380614 OR5M1;OR8U8 0.39 6.16 0.35 2.7e-9 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13411962 chr8:28243934 ZNF395 0.59 7.2 0.4 6.07e-12 Gut microbiome composition (summer); CESC cis rs9549367 0.713 rs3024761 chr13:113824090 C/G cg18105134 chr13:113819100 PROZ 0.64 7.63 0.42 4.32e-13 Platelet distribution width; CESC trans rs1814175 0.817 rs3974439 chr11:50022607 G/A cg15704280 chr7:45808275 SEPT13 -1.05 -21.18 -0.79 6.15e-59 Height; CESC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg18876405 chr7:65276391 NA 0.73 10.35 0.54 2.61e-21 Calcium levels; CESC cis rs7772486 0.658 rs6570706 chr6:145962922 T/C cg05347473 chr6:146136440 FBXO30 0.52 6.83 0.39 5.76e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs722599 0.748 rs2537824 chr14:75367349 T/C cg08847533 chr14:75593920 NEK9 -0.46 -5.53 -0.32 7.72e-8 IgG glycosylation; CESC cis rs1568889 0.548 rs34906813 chr11:28508819 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.55 5.27 0.31 2.84e-7 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08944318 chr10:15139147 RPP38;C10orf111 -0.45 -6.47 -0.37 4.78e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg24250549 chr1:154909240 PMVK 0.72 10.38 0.54 2.12e-21 Prostate cancer; CESC cis rs10504073 0.584 rs4873306 chr8:49950369 T/C cg00325661 chr8:49890786 NA 0.56 8.53 0.46 1.16e-15 Blood metabolite ratios; CESC cis rs78707713 0.560 rs61848436 chr10:71247714 C/T cg08851181 chr10:71228077 TSPAN15 -0.4 -5.03 -0.3 8.9e-7 Venous thromboembolism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05990579 chr15:40531343 PAK6 -0.45 -6.27 -0.36 1.47e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12042938 0.600 rs823163 chr1:231771108 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.41 5.54 0.32 7.41e-8 Neuranatomic and neurocognitive phenotypes; CESC trans rs11098499 0.710 rs4145952 chr4:120155806 C/A cg25214090 chr10:38739885 LOC399744 0.54 7.23 0.41 5.33e-12 Corneal astigmatism; CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg09177884 chr7:1199841 ZFAND2A -0.68 -9.34 -0.5 4.23e-18 Longevity;Endometriosis; CESC cis rs7084402 0.967 rs1658481 chr10:60289339 A/G cg07615347 chr10:60278583 BICC1 0.61 9.69 0.51 3.29e-19 Refractive error; CESC trans rs526821 0.595 rs504661 chr11:55312683 A/G cg15704280 chr7:45808275 SEPT13 -0.52 -6.37 -0.36 8.32e-10 Pediatric bone mineral density (spine); CESC cis rs55728055 0.661 rs62237857 chr22:32039311 G/A cg01338084 chr22:32026380 PISD 1.29 8.72 0.47 3.17e-16 Age-related hearing impairment; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24451981 chr15:40453319 BUB1B -0.47 -6.52 -0.37 3.59e-10 Asthma; CESC cis rs9325144 0.723 rs11169482 chr12:39164327 A/T cg26384229 chr12:38710491 ALG10B 0.52 7.14 0.4 9.07e-12 Morning vs. evening chronotype; CESC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg18032046 chr6:28092343 ZSCAN16 -0.6 -6.82 -0.39 6.29e-11 Depression; CESC cis rs3026101 0.671 rs75669379 chr17:5321355 G/C cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.59 0.32 5.61e-8 Body mass index; CESC cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg23711669 chr6:146136114 FBXO30 0.97 14.47 0.66 2.25e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs2919869 0.500 rs2970893 chr2:88415930 C/A cg07952391 chr2:88470173 THNSL2 -0.38 -5.09 -0.3 6.92e-7 Night sleep phenotypes; CESC cis rs861020 0.606 rs657844 chr1:210006873 T/G cg05527609 chr1:210001259 C1orf107 0.73 9.55 0.51 8.98e-19 Orofacial clefts; CESC cis rs861020 0.771 rs126280 chr1:210019824 A/G cg05527609 chr1:210001259 C1orf107 1.01 13.9 0.65 2.24e-33 Orofacial clefts; CESC cis rs17376456 0.877 rs10073039 chr5:93467709 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.11 0.3 6.27e-7 Diabetic retinopathy; CESC cis rs9915657 0.870 rs720244 chr17:70131643 G/T cg09344028 chr17:70110421 NA 0.35 6.25 0.36 1.59e-9 Thyroid hormone levels; CESC cis rs853679 1.000 rs1679709 chr6:28228342 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL -0.78 -7.87 -0.44 9.03e-14 Depression; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg20930618 chr1:151162157 VPS72 -0.51 -6.98 -0.39 2.34e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs8072100 0.512 rs3809863 chr17:45385012 C/T cg08085267 chr17:45401833 C17orf57 -0.54 -7.07 -0.4 1.37e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs35306767 0.714 rs12783621 chr10:1083304 C/T cg26597838 chr10:835615 NA 0.51 5.4 0.31 1.47e-7 Eosinophil percentage of granulocytes; CESC cis rs4481887 0.893 rs7528645 chr1:248427291 T/A cg00666640 chr1:248458726 OR2T12 0.34 5.83 0.34 1.64e-8 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09194755 chr16:68298776 SLC7A6 -0.55 -6.2 -0.36 2.14e-9 Gut microbiome composition (summer); CESC cis rs2303759 0.914 rs2288481 chr19:49878196 G/A cg22307029 chr19:49891270 CCDC155 0.59 6.15 0.35 2.9e-9 Multiple sclerosis; CESC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.25 -0.36 1.67e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg08736216 chr1:53307985 ZYG11A 0.42 7.11 0.4 1.06e-11 Monocyte count; CESC cis rs921968 0.541 rs485975 chr2:219374250 C/T cg02176678 chr2:219576539 TTLL4 0.5 8.93 0.48 7.55e-17 Mean corpuscular hemoglobin concentration; CESC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg16606324 chr3:10149918 C3orf24 0.42 5.17 0.3 4.58e-7 Alzheimer's disease; CESC cis rs12458462 0.787 rs56006341 chr18:77439844 G/T cg23301140 chr18:77439876 CTDP1 0.56 7.52 0.42 8.62e-13 Monocyte count; CESC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg26354017 chr1:205819088 PM20D1 0.5 7.23 0.41 5.3e-12 Menarche (age at onset); CESC cis rs73058052 0.597 rs10406941 chr19:50091464 A/C cg09250473 chr19:50168907 IRF3;BCL2L12 0.48 5.17 0.3 4.7e-7 Fibrinogen levels; CESC cis rs4906332 0.811 rs2021965 chr14:103997248 C/A cg04998671 chr14:104000505 TRMT61A 0.42 5.09 0.3 6.8e-7 Coronary artery disease; CESC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg06600287 chr1:53387719 ECHDC2 -0.29 -5.06 -0.3 7.92e-7 Monocyte count; CESC cis rs2816062 0.786 rs2745316 chr1:18896830 G/A cg18795169 chr1:18902165 NA -0.93 -18.37 -0.75 3.6e-49 Urate levels in lean individuals; CESC cis rs2228479 0.717 rs2286392 chr16:89809549 A/G cg14709524 chr16:89940631 TCF25 0.63 5.69 0.33 3.43e-8 Skin colour saturation; CESC cis rs6089584 1.000 rs6089587 chr20:60564829 C/T cg06108461 chr20:60628389 TAF4 -0.78 -11.36 -0.57 1.25e-24 Body mass index; CESC cis rs763121 0.853 rs2294296 chr22:39053049 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.6 0.47 7.32e-16 Menopause (age at onset); CESC cis rs9796 0.870 rs11854472 chr15:41357687 G/A cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.83 -0.39 5.74e-11 Menopause (age at onset); CESC cis rs6815814 0.950 rs11722788 chr4:38810738 C/G cg02016764 chr4:38805732 TLR1 -0.62 -7.33 -0.41 2.77e-12 Breast cancer; CESC cis rs4268898 0.760 rs11676939 chr2:24479057 C/T cg06627628 chr2:24431161 ITSN2 0.57 7.28 0.41 3.85e-12 Asthma; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg21237687 chr17:6899380 ALOX12 0.5 8.49 0.46 1.51e-15 Tonsillectomy; CESC cis rs9858542 0.953 rs71324979 chr3:49619651 T/C cg03060546 chr3:49711283 APEH -0.52 -6.04 -0.35 5.13e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs10506458 1.000 rs12425655 chr12:63434463 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.24 -16.98 -0.72 3.02e-44 Hemostatic factors and hematological phenotypes; CESC trans rs561341 0.843 rs879945 chr17:30242796 G/A cg20587970 chr11:113659929 NA -0.75 -9.69 -0.51 3.42e-19 Hip circumference adjusted for BMI; CESC cis rs12701220 0.894 rs2141274 chr7:1034717 G/A cg20821713 chr7:1055600 C7orf50 -0.49 -5.16 -0.3 4.9e-7 Bronchopulmonary dysplasia; CESC cis rs12451471 0.620 rs11150846 chr17:78098520 C/T cg06718696 chr17:78121285 EIF4A3 0.84 10.75 0.55 1.31e-22 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs8060686 0.516 rs1975802 chr16:68285847 A/G cg26727032 chr16:67993705 SLC12A4 -0.61 -8.42 -0.46 2.36e-15 HDL cholesterol;Metabolic syndrome; CESC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.57 0.64 3.26e-32 Prudent dietary pattern; CESC trans rs10463316 0.894 rs7708499 chr5:150765906 A/C cg24389359 chr12:111284228 CCDC63 -0.34 -6.08 -0.35 4.19e-9 Metabolite levels (Pyroglutamine); CESC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg12963246 chr6:28129442 ZNF389 0.59 7.68 0.43 3e-13 Depression; CESC cis rs7851660 0.874 rs7860144 chr9:100626884 A/G cg13688889 chr9:100608707 NA -0.63 -8.88 -0.48 1.05e-16 Strep throat; CESC cis rs644799 1.000 rs487609 chr11:95588102 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.26 0.36 1.54e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7000551 0.581 rs4872487 chr8:22256414 C/T cg12081754 chr8:22256438 SLC39A14 0.92 13.27 0.63 3.79e-31 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06557630 chr16:49889701 NA -0.44 -6.25 -0.36 1.63e-9 Ulcerative colitis; CESC cis rs9467711 0.606 rs28360517 chr6:26602453 A/G cg21479132 chr6:26055353 NA 0.58 5.18 0.3 4.44e-7 Autism spectrum disorder or schizophrenia; CESC cis rs4561483 0.603 rs17235629 chr16:11932421 C/T cg08843971 chr16:11963173 GSPT1 -0.45 -6.21 -0.36 2.07e-9 Testicular germ cell tumor; CESC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg17372223 chr3:52568218 NT5DC2 0.43 6.4 0.37 7.18e-10 Bipolar disorder; CESC cis rs35110281 0.715 rs2838353 chr21:45119228 C/T cg04455712 chr21:45112962 RRP1B 0.51 7.96 0.44 5.17e-14 Mean corpuscular volume; CESC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.04 -0.3 8.58e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6570726 0.902 rs4895678 chr6:145935510 C/T cg23711669 chr6:146136114 FBXO30 0.67 9.7 0.51 3.01e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs2228479 0.867 rs11645970 chr16:89958118 G/A cg04013166 chr16:89971882 TCF25 0.78 7.19 0.4 6.56e-12 Skin colour saturation; CESC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg18490616 chr2:88469792 THNSL2 0.55 5.25 0.31 3.06e-7 Plasma clusterin levels; CESC cis rs12618769 0.597 rs72821930 chr2:99127525 C/T cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs11711311 1.000 rs2305546 chr3:113503354 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.6 7.85 0.43 1e-13 IgG glycosylation; CESC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg07952391 chr2:88470173 THNSL2 0.62 6.03 0.35 5.61e-9 Plasma clusterin levels; CESC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg19717773 chr7:2847554 GNA12 -0.57 -8.09 -0.44 2.2e-14 Height; CESC trans rs3942852 0.568 rs10769314 chr11:48097620 C/T cg15704280 chr7:45808275 SEPT13 -0.72 -9.39 -0.5 2.86e-18 Acute lymphoblastic leukemia (childhood); CESC cis rs7020830 0.825 rs13297152 chr9:37075623 C/T cg14294708 chr9:37120828 ZCCHC7 1.25 22.61 0.81 8.68e-64 Schizophrenia; CESC cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg14440974 chr22:39074834 NA -0.42 -5.83 -0.34 1.62e-8 Menopause (age at onset); CESC cis rs3733585 0.699 rs4276278 chr4:9948870 T/C cg02734326 chr4:10020555 SLC2A9 -0.41 -5.76 -0.33 2.38e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.61 -7.87 -0.44 8.79e-14 Total body bone mineral density; CESC cis rs3749237 0.595 rs4855861 chr3:49525962 G/T cg02487422 chr3:49467188 NICN1 0.56 8.19 0.45 1.09e-14 Resting heart rate; CESC cis rs599083 0.530 rs2472415 chr11:68185616 T/C cg01657329 chr11:68192670 LRP5 0.44 5.21 0.3 3.85e-7 Bone mineral density (spine); CESC cis rs11828289 0.660 rs79043125 chr11:23203646 T/A cg20040320 chr11:23191996 NA -0.71 -6.12 -0.35 3.31e-9 Cancer; CESC cis rs7044106 0.791 rs4837792 chr9:123483559 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.01 0.62 3.06e-30 Hip circumference adjusted for BMI; CESC cis rs4588572 0.643 rs1019803 chr5:77739154 A/G cg11547950 chr5:77652471 NA -0.46 -5.73 -0.33 2.78e-8 Triglycerides; CESC cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg24308560 chr3:49941425 MST1R 0.6 8.61 0.47 6.54e-16 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.44 -0.37 5.7e-10 Depression; CESC cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg01579765 chr21:45077557 HSF2BP -0.5 -8.22 -0.45 9.39e-15 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17325912 chr2:97520089 ANKRD39 -0.55 -6.31 -0.36 1.2e-9 Gut microbiome composition (summer); CESC cis rs9902453 1.000 rs62070270 chr17:28263980 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.4 0.46 2.73e-15 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13700589 chr9:15511220 PSIP1 0.63 6.95 0.39 2.9e-11 Gut microbiome composition (summer); CESC cis rs1577917 0.798 rs7772384 chr6:86639680 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -5.94 -0.34 8.86e-9 Response to antipsychotic treatment; CESC cis rs2243480 1.000 rs4145008 chr7:65647511 T/G cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.24e-32 Diabetic kidney disease; CESC cis rs899997 0.862 rs57260218 chr15:78973772 C/T cg04896959 chr15:78267971 NA -0.41 -5.78 -0.33 2.12e-8 Coronary artery disease or large artery stroke; CESC trans rs853679 0.769 rs17720293 chr6:28214698 C/T cg06606381 chr12:133084897 FBRSL1 -0.83 -7.58 -0.42 5.68e-13 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25327839 chr11:73308997 FAM168A 0.56 6.0 0.35 6.56e-9 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19905630 chr1:149721664 NA 0.39 6.47 0.37 4.68e-10 Gambling; CESC cis rs2749592 0.550 rs10764135 chr10:37866845 C/T cg00409905 chr10:38381863 ZNF37A 0.43 5.71 0.33 2.99e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs863345 0.967 rs11265000 chr1:158488899 A/C cg12129480 chr1:158549410 OR10X1 -0.3 -5.7 -0.33 3.24e-8 Pneumococcal bacteremia; CESC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.64e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs4700695 0.719 rs27046 chr5:65439964 G/C cg21114390 chr5:65439923 SFRS12 -0.55 -6.65 -0.38 1.71e-10 Facial morphology (factor 19); CESC cis rs1538970 0.924 rs4660851 chr1:45843810 A/T cg06784218 chr1:46089804 CCDC17 0.32 5.55 0.32 7.01e-8 Platelet count; CESC cis rs7771547 0.573 rs584418 chr6:36395437 G/A cg04289385 chr6:36355825 ETV7 0.38 5.57 0.32 6.41e-8 Platelet distribution width; CESC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg18758796 chr5:131593413 PDLIM4 0.45 6.52 0.37 3.58e-10 Breast cancer; CESC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg13647721 chr17:30228624 UTP6 -0.62 -5.84 -0.34 1.5e-8 Hip circumference adjusted for BMI; CESC cis rs1670533 1.000 rs10902752 chr4:1056199 C/T cg04106633 chr4:1044584 NA 0.41 5.19 0.3 4.11e-7 Recombination rate (females); CESC cis rs36051895 0.589 rs6476946 chr9:5195275 C/G cg02405213 chr9:5042618 JAK2 0.52 5.95 0.34 8.62e-9 Pediatric autoimmune diseases; CESC cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.51 0.46 1.33e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.66 0.61 4.8e-29 Colonoscopy-negative controls vs population controls; CESC cis rs735396 1.000 rs2259852 chr12:121434833 G/A cg25281562 chr12:121454272 C12orf43 0.39 5.12 0.3 5.93e-7 N-glycan levels; CESC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 9.55 0.51 9.28e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6580649 0.941 rs3742074 chr12:48457385 C/T cg24011408 chr12:48396354 COL2A1 -0.42 -5.28 -0.31 2.67e-7 Lung cancer; CESC cis rs5753618 0.561 rs5749265 chr22:31796897 A/C cg02404636 chr22:31891804 SFI1 0.39 5.37 0.31 1.71e-7 Colorectal cancer; CESC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg02269571 chr22:50332266 NA -0.56 -6.99 -0.39 2.26e-11 Schizophrenia; CESC cis rs8063761 0.589 rs4238833 chr16:90050689 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 0.67 9.91 0.52 6.76e-20 Squamous cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19110795 chr3:196159589 UBXN7 0.58 6.51 0.37 3.76e-10 Gut microbiome composition (summer); CESC cis rs11809207 0.574 rs2783630 chr1:26504741 G/A cg00147160 chr1:26503991 CNKSR1 0.29 5.44 0.32 1.21e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18278596 chr14:105915860 MTA1 -0.68 -8.03 -0.44 3.16e-14 Gut microbiome composition (summer); CESC cis rs7089973 0.604 rs765173 chr10:116601675 C/T cg23260525 chr10:116636907 FAM160B1 0.41 7.9 0.44 7.32e-14 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11266582 chr15:64275853 DAPK2 -0.58 -6.33 -0.36 1.02e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs34212748 chr4:99068708 G/A cg03467027 chr4:99064603 C4orf37 0.48 5.96 0.34 7.81e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg22974920 chr21:40686053 BRWD1 -0.45 -5.61 -0.33 4.99e-8 Cognitive function; CESC trans rs3942852 0.915 rs905477 chr11:48148606 T/C cg03929089 chr4:120376271 NA -0.6 -6.41 -0.37 6.75e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs8180040 0.902 rs73081205 chr3:47517670 A/C cg27129171 chr3:47204927 SETD2 -0.63 -9.49 -0.5 1.38e-18 Colorectal cancer; CESC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.76 -12.85 -0.62 1.07e-29 Personality dimensions; CESC cis rs2243480 1.000 rs387676 chr7:65598220 C/T cg12463550 chr7:65579703 CRCP 0.73 5.68 0.33 3.5e-8 Diabetic kidney disease; CESC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg04546413 chr19:29218101 NA 0.55 7.53 0.42 8.13e-13 Methadone dose in opioid dependence; CESC cis rs3733585 0.699 rs28613263 chr4:9964880 C/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9308433 0.553 rs9308435 chr1:214500166 C/T cg06198575 chr1:214491504 SMYD2 0.51 6.1 0.35 3.72e-9 IgG glycosylation; CESC cis rs12479064 0.724 rs62153852 chr2:99934713 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.7 -0.43 2.65e-13 Chronic sinus infection; CESC cis rs35362007 0.530 rs11621250 chr14:96011442 C/T cg13511115 chr14:96000878 GLRX5;SNHG10;SCARNA13 0.66 5.36 0.31 1.81e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs910316 1.000 rs8017642 chr14:75590822 G/A cg11812906 chr14:75593930 NEK9 0.89 15.29 0.68 2.88e-38 Height; CESC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg09491104 chr22:46646882 C22orf40 -0.49 -5.84 -0.34 1.53e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6693567 0.507 rs828784 chr1:150335240 T/A cg09579323 chr1:150459698 TARS2 0.48 6.09 0.35 3.89e-9 Migraine; CESC cis rs67311347 0.544 rs9864601 chr3:40345318 C/T cg09455208 chr3:40491958 NA 0.37 6.51 0.37 3.77e-10 Renal cell carcinoma; CESC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg20203395 chr5:56204925 C5orf35 -0.44 -5.29 -0.31 2.57e-7 Initial pursuit acceleration; CESC cis rs1348850 0.632 rs10167783 chr2:178519041 G/A cg23306229 chr2:178417860 TTC30B 0.57 6.86 0.39 4.86e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1559088 0.847 rs2287679 chr19:33600764 T/C cg27124370 chr19:33622961 WDR88 0.45 5.86 0.34 1.34e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs13191362 0.507 rs2510207 chr6:163086592 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.68 -8.08 -0.44 2.28e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6963495 0.818 rs818621 chr7:105173029 T/C cg13798780 chr7:105162888 PUS7 0.62 7.06 0.4 1.45e-11 Bipolar disorder (body mass index interaction); CESC cis rs4974559 0.739 rs35571200 chr4:1268129 G/A cg02980000 chr4:1222292 CTBP1 -0.71 -7.15 -0.4 8.42e-12 Systolic blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10440939 chr17:27493798 MYO18A 0.49 6.68 0.38 1.43e-10 Fibrinogen levels; CESC cis rs7786877 0.680 rs28584500 chr7:100216341 G/A cg27028030 chr7:100209634 MOSPD3 0.57 5.59 0.32 5.72e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs5769765 1.000 rs2295408 chr22:50261051 A/G cg02269571 chr22:50332266 NA 0.46 6.2 0.36 2.13e-9 Schizophrenia; CESC cis rs7923609 0.936 rs10761779 chr10:65274927 A/G cg01631684 chr10:65280961 REEP3 -0.44 -5.45 -0.32 1.14e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs916888 0.687 rs199456 chr17:44797919 C/T cg27589368 chr17:43923255 LOC100128977;IMP5 -0.39 -5.24 -0.31 3.31e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs910316 0.503 rs12894709 chr14:75441734 G/A cg11812906 chr14:75593930 NEK9 0.64 9.37 0.5 3.41e-18 Height; CESC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg09365446 chr1:150670422 GOLPH3L -0.42 -5.84 -0.34 1.55e-8 Tonsillectomy; CESC cis rs6541297 0.645 rs2103827 chr1:230298285 T/A cg20703242 chr1:230279135 GALNT2 0.57 6.49 0.37 4.14e-10 Coronary artery disease; CESC cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg03676636 chr4:99064102 C4orf37 0.35 5.3 0.31 2.45e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11086275 chr1:180991441 STX6 0.58 6.61 0.38 2.15e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.08 -12.62 -0.61 6.57e-29 Gut microbiome composition (summer); CESC cis rs3767633 0.764 rs4233381 chr1:161910720 T/C cg09175582 chr1:161736000 ATF6 0.85 5.41 0.32 1.38e-7 IgG glycosylation; CESC cis rs7937682 0.855 rs7109592 chr11:111533105 C/A cg22437258 chr11:111473054 SIK2 0.68 9.21 0.49 1e-17 Primary sclerosing cholangitis; CESC cis rs782590 0.967 rs782586 chr2:55836165 A/C cg18811423 chr2:55921094 PNPT1 0.8 13.14 0.63 1.09e-30 Metabolic syndrome; CESC cis rs4919687 0.550 rs7904252 chr10:104456725 A/C cg04362960 chr10:104952993 NT5C2 -0.43 -5.12 -0.3 5.94e-7 Colorectal cancer; CESC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg18876405 chr7:65276391 NA -0.51 -6.96 -0.39 2.72e-11 Aortic root size; CESC cis rs113835537 0.866 rs59320108 chr11:66365996 A/T cg22134325 chr11:66188745 NPAS4 0.5 5.7 0.33 3.24e-8 Airway imaging phenotypes; CESC cis rs4253772 0.550 rs738444 chr22:46721088 C/T cg09491104 chr22:46646882 C22orf40 -0.59 -8.67 -0.47 4.32e-16 LDL cholesterol;Cholesterol, total; CESC trans rs55704346 0.566 rs6848308 chr4:25394401 C/G cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs9399135 0.967 rs4895436 chr6:135295001 G/A cg22676075 chr6:135203613 NA 0.52 7.21 0.4 5.94e-12 Red blood cell count; CESC cis rs9308433 0.643 rs4655330 chr1:214466068 A/G cg06198575 chr1:214491504 SMYD2 -0.43 -5.14 -0.3 5.29e-7 IgG glycosylation; CESC cis rs4699052 0.662 rs1996346 chr4:104250324 C/T cg16532752 chr4:104119610 CENPE -0.4 -5.65 -0.33 4.24e-8 Testicular germ cell tumor; CESC cis rs7829975 0.777 rs486781 chr8:8639740 A/G cg15556689 chr8:8085844 FLJ10661 -0.42 -5.23 -0.31 3.37e-7 Mood instability; CESC cis rs12477438 0.501 rs6753063 chr2:99801469 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.21 0.68 5.36e-38 Chronic sinus infection; CESC cis rs3820068 0.581 rs16851841 chr1:15922713 A/G cg16988262 chr1:15930761 NA 0.35 5.69 0.33 3.38e-8 Systolic blood pressure; CESC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg19592336 chr6:28129416 ZNF389 0.44 6.39 0.37 7.51e-10 Parkinson's disease; CESC cis rs2197308 0.765 rs11182434 chr12:37923968 C/A cg26384229 chr12:38710491 ALG10B 0.75 11.12 0.56 8.21e-24 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22079616 chr13:21141624 IFT88 0.52 6.17 0.35 2.57e-9 Gut microbiome composition (summer); CESC cis rs11997175 0.546 rs4733448 chr8:33628575 G/A ch.8.33884649F chr8:33765107 NA 0.56 7.26 0.41 4.36e-12 Body mass index; CESC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.85 12.01 0.59 8.38e-27 Age-related macular degeneration (geographic atrophy); CESC cis rs9287719 0.935 rs728283 chr2:10750090 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs501120 1.000 rs607363 chr10:44761623 A/G cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.1e-11 Coronary artery disease;Coronary heart disease; CESC cis rs561341 1.000 rs8077092 chr17:30281992 T/C cg12193833 chr17:30244370 NA -0.6 -6.06 -0.35 4.7e-9 Hip circumference adjusted for BMI; CESC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.66 -7.43 -0.42 1.51e-12 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg07936489 chr17:37558343 FBXL20 0.73 9.81 0.52 1.43e-19 Glomerular filtration rate (creatinine); CESC cis rs6429082 0.967 rs834143 chr1:235626406 C/T cg26050004 chr1:235667680 B3GALNT2 0.47 6.35 0.36 9.23e-10 Adiposity; CESC cis rs35110281 0.837 rs2838342 chr21:45077865 G/A cg21573476 chr21:45109991 RRP1B -0.48 -6.8 -0.39 7.09e-11 Mean corpuscular volume; CESC cis rs28374715 0.681 rs7163989 chr15:41614621 A/G cg18705301 chr15:41695430 NDUFAF1 -0.77 -11.04 -0.56 1.41e-23 Ulcerative colitis; CESC cis rs12479064 0.671 rs4851207 chr2:100105775 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -6.99 -0.39 2.28e-11 Chronic sinus infection; CESC cis rs13126513 0.510 rs10516445 chr4:100524679 C/G cg05468953 chr4:100565104 NA 0.34 5.38 0.31 1.63e-7 Metabolite levels (MHPG); CESC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg09359103 chr1:154839909 KCNN3 -0.65 -12.25 -0.6 1.22e-27 Prostate cancer; CESC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg04944784 chr2:26401820 FAM59B -0.65 -7.24 -0.41 4.83e-12 Gut microbiome composition (summer); CESC cis rs7917772 0.503 rs7893155 chr10:104294228 C/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.17 0.3 4.66e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs727505 1.000 rs67552763 chr7:124517857 A/G cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07184411 chr3:122400006 PARP14 -0.51 -6.93 -0.39 3.25e-11 Asthma; CESC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg23978390 chr7:1156363 C7orf50 0.61 8.86 0.48 1.15e-16 Longevity;Endometriosis; CESC trans rs1994135 0.669 rs2121831 chr12:33697674 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.6 0.38 2.22e-10 Resting heart rate; CESC cis rs7772486 0.686 rs1045820 chr6:145947080 C/T cg05347473 chr6:146136440 FBXO30 0.53 6.94 0.39 3.1e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1355223 0.506 rs7131272 chr11:34869548 A/G cg11622362 chr11:34938112 PDHX;APIP -0.48 -5.77 -0.33 2.22e-8 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs10791097 0.694 rs4936123 chr11:130740967 G/A cg12179176 chr11:130786555 SNX19 0.71 11.75 0.59 6.16e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs997295 0.592 rs7162320 chr15:67766038 C/G cg05081167 chr6:156967138 NA 0.28 6.08 0.35 4.1e-9 Motion sickness; CESC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg08109568 chr15:31115862 NA -0.71 -9.4 -0.5 2.77e-18 Huntington's disease progression; CESC cis rs6570726 0.905 rs396492 chr6:145816180 C/G cg23711669 chr6:146136114 FBXO30 0.77 11.31 0.57 1.91e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs9549367 0.789 rs12584981 chr13:113881185 T/C cg00898013 chr13:113819073 PROZ -0.49 -6.78 -0.38 7.6e-11 Platelet distribution width; CESC cis rs977987 0.735 rs11149831 chr16:75451461 G/A cg03315344 chr16:75512273 CHST6 0.41 5.65 0.33 4.22e-8 Dupuytren's disease; CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg03188948 chr7:1209495 NA 0.51 6.62 0.38 1.95e-10 Longevity;Endometriosis; CESC cis rs9486719 0.843 rs2499792 chr6:96846264 A/C cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg22549504 chr19:17448937 GTPBP3 0.49 5.51 0.32 8.32e-8 Systemic lupus erythematosus; CESC cis rs752092 1.000 rs7182945 chr15:101784223 C/T cg19997662 chr15:101784653 CHSY1 -0.56 -7.69 -0.43 2.86e-13 Corneal structure; CESC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.86 9.62 0.51 5.43e-19 Gut microbiome composition (summer); CESC cis rs2859741 0.528 rs3753776 chr1:37480144 C/T cg09363841 chr1:37513479 NA -0.49 -7.03 -0.4 1.8e-11 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs2933343 0.729 rs1683816 chr3:128651195 G/T cg24203234 chr3:128598194 ACAD9 -0.44 -5.81 -0.34 1.83e-8 IgG glycosylation; CESC cis rs858239 0.537 rs6955115 chr7:23227144 A/G cg23682824 chr7:23144976 KLHL7 0.45 5.85 0.34 1.46e-8 Cerebrospinal fluid biomarker levels; CESC cis rs1707322 0.721 rs28817701 chr1:46186050 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7959452 0.640 rs10878957 chr12:69699638 G/C cg14784868 chr12:69753453 YEATS4 0.73 10.44 0.54 1.35e-21 Blood protein levels; CESC cis rs9911578 0.935 rs2567912 chr17:56731270 T/C cg05425664 chr17:57184151 TRIM37 -0.51 -7.14 -0.4 8.78e-12 Intelligence (multi-trait analysis); CESC cis rs116095464 0.558 rs7708182 chr5:234788 C/G cg10591111 chr5:226296 SDHA -0.51 -6.29 -0.36 1.32e-9 Breast cancer; CESC trans rs2749592 0.550 rs4934881 chr10:37914346 A/C cg12057190 chr19:54976211 LENG9;CDC42EP5 -0.43 -6.15 -0.35 2.91e-9 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05564938 chr15:59280649 RNF111 -0.5 -6.07 -0.35 4.41e-9 Ulcerative colitis; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg19536664 chr17:6899085 ALOX12 -0.38 -8.42 -0.46 2.32e-15 Tonsillectomy; CESC cis rs7580658 0.926 rs4662725 chr2:128141320 G/A cg10021288 chr2:128175891 PROC -0.41 -6.47 -0.37 4.66e-10 Protein C levels; CESC cis rs1348850 0.914 rs10170546 chr2:178248790 C/T cg22681709 chr2:178499509 PDE11A -0.43 -6.29 -0.36 1.33e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs939574 1.000 rs9989854 chr2:220086280 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.62 -6.0 -0.35 6.35e-9 Platelet distribution width; CESC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg09263875 chr16:632152 PIGQ 0.68 11.78 0.59 4.9e-26 Height; CESC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg12034118 chr1:209979487 IRF6 0.47 5.78 0.33 2.04e-8 Cleft lip with or without cleft palate; CESC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg16145915 chr7:1198662 ZFAND2A -0.45 -6.41 -0.37 6.53e-10 Longevity;Endometriosis; CESC cis rs1580019 0.520 rs13228793 chr7:32711465 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.94 11.52 0.58 3.69e-25 Cognitive ability; CESC cis rs9488822 0.702 rs12196154 chr6:116327471 T/G cg18764771 chr6:116381957 FRK 0.22 5.42 0.32 1.35e-7 Cholesterol, total;LDL cholesterol; CESC trans rs875971 0.964 rs12668936 chr7:65914404 C/T cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs1728785 1.000 rs698728 chr16:68625253 T/C cg02972257 chr16:68554789 NA -0.64 -7.22 -0.41 5.58e-12 Ulcerative colitis; CESC cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg26597838 chr10:835615 NA 0.78 9.19 0.49 1.21e-17 Eosinophil percentage of granulocytes; CESC trans rs9325144 0.555 rs1813392 chr12:38692203 C/T cg23762105 chr12:34175262 ALG10 0.5 6.7 0.38 1.28e-10 Morning vs. evening chronotype; CESC cis rs12477438 0.765 rs2167930 chr2:99592551 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.51 -0.54 7.92e-22 Chronic sinus infection; CESC cis rs12893668 0.703 rs4906337 chr14:104040414 C/A cg24130564 chr14:104152367 KLC1 -0.47 -5.73 -0.33 2.71e-8 Reticulocyte count; CESC cis rs1355223 0.902 rs4465347 chr11:34727333 C/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.24 -0.36 1.68e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg21399703 chr1:247681439 NA 0.55 7.37 0.41 2.13e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg02569458 chr12:86230093 RASSF9 0.47 6.96 0.39 2.7e-11 Major depressive disorder; CESC cis rs3820068 0.705 rs4645983 chr1:15850603 G/A cg17385448 chr1:15911702 AGMAT 0.36 5.75 0.33 2.43e-8 Systolic blood pressure; CESC cis rs28647808 0.881 rs3739894 chr9:136270871 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC trans rs8073060 0.559 rs10438814 chr17:34007065 A/G cg19694781 chr19:47549865 TMEM160 -0.71 -6.74 -0.38 9.95e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs9325144 0.560 rs1825802 chr12:38650341 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.1 -0.35 3.79e-9 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17298884 chr22:42343226 CENPM -0.44 -6.15 -0.35 2.87e-9 Fibrinogen levels; CESC cis rs7208859 0.623 rs8068645 chr17:29104342 T/A cg19761014 chr17:28927070 LRRC37B2 0.75 6.17 0.35 2.49e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs367943 0.712 rs1850407 chr5:112721569 C/A cg12552261 chr5:112820674 MCC 0.39 5.22 0.31 3.62e-7 Type 2 diabetes; CESC cis rs12220238 1.000 rs7904207 chr10:75884474 A/T cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.34 0.36 9.58e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs1801251 0.752 rs709938 chr2:233746457 C/T cg08000102 chr2:233561755 GIGYF2 -0.58 -7.87 -0.44 9.23e-14 Coronary artery disease; CESC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg24829409 chr8:58192753 C8orf71 -0.66 -7.93 -0.44 6.14e-14 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg18099408 chr3:52552593 STAB1 -0.3 -5.11 -0.3 6.18e-7 Bipolar disorder; CESC cis rs2243480 1.000 rs1167613 chr7:65487439 C/T cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs11650494 0.901 rs117087923 chr17:47364913 G/A cg08112188 chr17:47440006 ZNF652 1.3 8.47 0.46 1.73e-15 Prostate cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23676784 chr1:22968681 C1QC -0.4 -6.03 -0.35 5.39e-9 Gambling; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24947615 chr21:44515479 U2AF1 0.57 7.5 0.42 9.85e-13 Fibrinogen levels; CESC cis rs15676 0.783 rs11515530 chr9:131576367 C/T cg00228799 chr9:131580591 ENDOG -0.54 -6.81 -0.39 6.66e-11 Blood metabolite levels; CESC trans rs61931739 0.517 rs4931771 chr12:34044557 G/A cg26384229 chr12:38710491 ALG10B 0.6 8.36 0.46 3.68e-15 Morning vs. evening chronotype; CESC cis rs1008375 1.000 rs6811887 chr4:17640858 C/T cg02297831 chr4:17616191 MED28 0.57 7.34 0.41 2.67e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs2997105 0.938 rs9597256 chr13:56331434 G/A cg11410726 chr11:69625409 FGF3 0.46 6.08 0.35 4.15e-9 Response to platinum-based chemotherapy (cisplatin); CESC cis rs12477438 0.798 rs4850894 chr2:99629396 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs9287719 0.967 rs4519489 chr2:10739087 A/T cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs12477438 0.520 rs11883676 chr2:99800814 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 15.36 0.69 1.63e-38 Chronic sinus infection; CESC cis rs35849525 0.633 rs62263602 chr3:50152491 C/T cg24110177 chr3:50126178 RBM5 -0.45 -5.06 -0.3 7.67e-7 Intelligence (multi-trait analysis); CESC cis rs2797160 1.000 rs1777194 chr6:126004883 G/A cg05901451 chr6:126070800 HEY2 -0.45 -6.54 -0.37 3.11e-10 Endometrial cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03242101 chr16:67143792 C16orf70 0.54 6.37 0.36 8.4e-10 Gut microbiome composition (summer); CESC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg24250549 chr1:154909240 PMVK 0.74 11.16 0.57 5.75e-24 Prostate cancer; CESC cis rs2228479 0.850 rs11649510 chr16:89851004 A/G cg14709524 chr16:89940631 TCF25 0.94 7.05 0.4 1.57e-11 Skin colour saturation; CESC cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg06636001 chr8:8085503 FLJ10661 0.54 6.44 0.37 5.46e-10 Mood instability; CESC cis rs56104184 0.775 rs56146968 chr19:49398847 A/G cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.83e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs4332037 0.950 rs7807014 chr7:1939021 T/C cg23422044 chr7:1970798 MAD1L1 -0.53 -5.33 -0.31 2.09e-7 Bipolar disorder; CESC cis rs9616064 0.531 rs17821649 chr22:47050387 G/A cg05621596 chr22:47072043 GRAMD4 -0.68 -9.8 -0.52 1.45e-19 Urate levels in obese individuals; CESC cis rs7210086 0.821 rs3935123 chr17:70641183 C/T cg04206342 chr17:70636940 NA 0.28 5.42 0.32 1.32e-7 Ulcerative colitis; CESC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg00908189 chr16:619842 PIGQ 0.63 8.69 0.47 3.72e-16 Height; CESC cis rs1395 0.778 rs17005956 chr2:27451099 C/T cg22903471 chr2:27725779 GCKR -0.42 -5.17 -0.3 4.56e-7 Blood metabolite levels; CESC cis rs9300255 0.602 rs1727313 chr12:123640853 C/G cg00376283 chr12:123451042 ABCB9 0.63 6.81 0.39 6.57e-11 Neutrophil percentage of white cells; CESC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg18099408 chr3:52552593 STAB1 -0.33 -5.47 -0.32 1.02e-7 Bipolar disorder; CESC trans rs408302 0.965 rs402280 chr21:31207718 A/T cg02473327 chr2:150080315 NA -0.39 -6.14 -0.35 3.05e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2180341 1.000 rs6569483 chr6:127658855 G/A cg27446573 chr6:127587934 RNF146 1.09 16.35 0.71 5.12e-42 Breast cancer; CESC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg27170947 chr2:26402098 FAM59B 0.66 7.3 0.41 3.41e-12 Gut microbiome composition (summer); CESC cis rs4843747 0.671 rs28465438 chr16:88103714 G/A cg06915872 chr16:87998081 BANP 0.45 5.29 0.31 2.61e-7 Menopause (age at onset); CESC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -12.6 -0.61 7.79e-29 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs10011865 chr4:17645710 G/A cg15017067 chr4:17643749 FAM184B 0.35 5.07 0.3 7.59e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2439831 0.850 rs2228368 chr15:44102010 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.72 8.11 0.45 1.87e-14 Lung cancer in ever smokers; CESC cis rs10504229 0.636 rs115738451 chr8:58055133 A/T cg22535103 chr8:58192502 C8orf71 -0.79 -8.14 -0.45 1.6e-14 Developmental language disorder (linguistic errors); CESC cis rs11785400 0.701 rs9297967 chr8:143723002 A/C cg10596483 chr8:143751796 JRK 0.4 5.14 0.3 5.32e-7 Schizophrenia; CESC cis rs9910055 0.529 rs183462 chr17:42183376 G/C cg13607699 chr17:42295918 UBTF -0.48 -6.0 -0.35 6.55e-9 Total body bone mineral density; CESC cis rs763121 0.853 rs4821816 chr22:39113134 G/A cg06022373 chr22:39101656 GTPBP1 0.94 18.11 0.74 2.87e-48 Menopause (age at onset); CESC cis rs7584330 0.554 rs76519914 chr2:238429818 G/A cg14458575 chr2:238380390 NA 0.53 5.71 0.33 2.98e-8 Prostate cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11586605 chr11:108535779 DDX10 -0.38 -6.0 -0.35 6.46e-9 Gambling; CESC cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg27266027 chr21:40555129 PSMG1 0.46 5.45 0.32 1.16e-7 Cognitive function; CESC cis rs3126085 0.935 rs11204981 chr1:152298212 C/T cg03465714 chr1:152285911 FLG 0.47 5.46 0.32 1.11e-7 Atopic dermatitis; CESC cis rs1707322 0.964 rs7546237 chr1:46285610 A/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.35e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7605827 0.930 rs10176967 chr2:15686086 G/T cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs4689388 0.853 rs6817447 chr4:6286847 G/T cg00701064 chr4:6280414 WFS1 0.73 12.96 0.62 4.55e-30 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs10870270 1.000 rs7898755 chr10:133777122 G/A cg26149184 chr10:133730230 NA 0.38 5.14 0.3 5.22e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02563685 chr8:117778752 UTP23 0.61 6.7 0.38 1.23e-10 Gut microbiome composition (summer); CESC cis rs2230307 0.536 rs564938 chr1:100592901 T/C cg24955406 chr1:100503596 HIAT1 -0.53 -5.31 -0.31 2.35e-7 Carotid intima media thickness; CESC cis rs12971120 0.891 rs11151961 chr18:72177340 C/T cg25817165 chr18:72167213 CNDP2 -0.61 -7.36 -0.41 2.37e-12 Refractive error; CESC cis rs208520 0.661 rs6937856 chr6:66867468 A/G cg07460842 chr6:66804631 NA -1.0 -13.45 -0.64 8.77e-32 Exhaled nitric oxide output; CESC cis rs977987 0.806 rs8057203 chr16:75404974 T/C cg03315344 chr16:75512273 CHST6 0.4 5.71 0.33 3.09e-8 Dupuytren's disease; CESC cis rs11958404 0.615 rs7717217 chr5:157447749 C/T cg05962755 chr5:157440814 NA 0.38 5.65 0.33 4.21e-8 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22677401 chr17:46026860 NA 0.59 7.03 0.4 1.73e-11 Gut microbiome composition (summer); CESC cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg19748678 chr4:122722346 EXOSC9 0.8 10.06 0.53 2.28e-20 Type 2 diabetes; CESC cis rs34779708 0.801 rs12246600 chr10:35538121 A/C cg04310649 chr10:35416472 CREM -0.47 -5.36 -0.31 1.83e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs7264396 0.676 rs6060730 chr20:34558503 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.18 0.36 2.37e-9 Total cholesterol levels; CESC cis rs2929278 0.617 rs524908 chr15:44187991 G/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.4 -6.43 -0.37 6.01e-10 Schizophrenia; CESC cis rs208520 0.661 rs207111 chr6:66792513 C/T cg07460842 chr6:66804631 NA -1.0 -13.33 -0.63 2.21e-31 Exhaled nitric oxide output; CESC cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.44 7.12 0.4 9.88e-12 Personality dimensions; CESC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg18876405 chr7:65276391 NA 0.52 7.09 0.4 1.24e-11 Aortic root size; CESC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg02574844 chr11:5959923 NA -0.46 -6.6 -0.38 2.2e-10 DNA methylation (variation); CESC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg11764359 chr7:65958608 NA 0.96 15.25 0.68 3.95e-38 Aortic root size; CESC cis rs7178572 0.633 rs907369 chr15:77843560 A/G cg22256960 chr15:77711686 NA -0.53 -6.5 -0.37 3.97e-10 Type 2 diabetes; CESC cis rs7769051 0.522 rs57176306 chr6:133142168 C/T cg22852734 chr6:133119734 C6orf192 0.87 6.23 0.36 1.84e-9 Type 2 diabetes nephropathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06719873 chr12:70133599 RAB3IP -0.53 -6.36 -0.36 8.81e-10 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs10075018 chr5:239175 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.25 0.31 3.1e-7 Breast cancer; CESC cis rs9470366 0.883 rs12199346 chr6:36641546 C/A cg08179530 chr6:36648295 CDKN1A 0.54 6.39 0.37 7.4e-10 QRS duration; CESC cis rs11190604 1.000 rs2489046 chr10:102346282 A/C cg07080220 chr10:102295463 HIF1AN 0.59 6.02 0.35 5.94e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs1005277 0.579 rs1780130 chr10:38485378 T/A cg00409905 chr10:38381863 ZNF37A -0.46 -6.13 -0.35 3.21e-9 Extrinsic epigenetic age acceleration; CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg25934064 chr3:52569026 NT5DC2 -0.25 -5.19 -0.3 4.22e-7 Electroencephalogram traits; CESC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg02725872 chr8:58115012 NA -0.36 -5.56 -0.32 6.54e-8 Developmental language disorder (linguistic errors); CESC cis rs10089 1.000 rs4836361 chr5:127459991 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.07 0.53 2.04e-20 Ileal carcinoids; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12354594 chr17:61850856 DDX42;CCDC47 0.55 6.32 0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs672059 0.966 rs689375 chr1:183160973 A/G ch.1.3577855R chr1:183094577 LAMC1 0.54 7.01 0.4 1.93e-11 Hypertriglyceridemia; CESC cis rs2243480 1.000 rs313832 chr7:65550891 G/T cg12463550 chr7:65579703 CRCP 0.7 5.4 0.31 1.48e-7 Diabetic kidney disease; CESC cis rs2880765 0.835 rs4360874 chr15:86040820 A/T cg10818794 chr15:86012489 AKAP13 -0.35 -5.39 -0.31 1.52e-7 Coronary artery disease; CESC cis rs2228479 0.850 rs12596934 chr16:89841605 T/G cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs7296418 0.961 rs11613937 chr12:123520071 C/T cg05973401 chr12:123451056 ABCB9 0.6 7.92 0.44 6.63e-14 Platelet count; CESC cis rs9902453 0.874 rs3936006 chr17:28257660 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 9.26 0.49 7.32e-18 Coffee consumption (cups per day); CESC cis rs7086627 0.515 rs10887900 chr10:82210265 A/G cg03267442 chr10:82210566 NA -0.33 -5.3 -0.31 2.48e-7 Post bronchodilator FEV1; CESC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs8180040 0.966 rs11705957 chr3:47443262 T/G cg27129171 chr3:47204927 SETD2 -0.64 -9.82 -0.52 1.29e-19 Colorectal cancer; CESC cis rs7824557 0.767 rs6991606 chr8:11176159 G/A cg21775007 chr8:11205619 TDH 0.47 6.82 0.39 5.98e-11 Retinal vascular caliber; CESC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg00784671 chr22:46762841 CELSR1 -0.51 -5.26 -0.31 3.02e-7 LDL cholesterol;Cholesterol, total; CESC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg12463550 chr7:65579703 CRCP 0.58 7.41 0.41 1.67e-12 Aortic root size; CESC cis rs3820068 0.581 rs1122386 chr1:15946877 C/T cg16988262 chr1:15930761 NA 0.34 5.45 0.32 1.13e-7 Systolic blood pressure; CESC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg25405998 chr7:65216604 CCT6P1 -0.5 -5.28 -0.31 2.64e-7 Aortic root size; CESC cis rs2243480 1.000 rs57057549 chr7:65405738 A/G cg12463550 chr7:65579703 CRCP 0.72 5.53 0.32 7.65e-8 Diabetic kidney disease; CESC cis rs34779708 0.931 rs2384283 chr10:35326789 G/A cg04310649 chr10:35416472 CREM -0.49 -5.94 -0.34 9.13e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs6484504 0.576 rs208083 chr11:31196880 C/T cg14844989 chr11:31128820 NA -0.38 -5.52 -0.32 7.98e-8 Red blood cell count; CESC cis rs637571 0.654 rs1058068 chr11:65667796 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.66 8.29 0.45 5.76e-15 Eosinophil percentage of white cells; CESC cis rs6120849 0.754 rs6120790 chr20:33599090 A/T cg24642439 chr20:33292090 TP53INP2 0.67 6.74 0.38 9.78e-11 Protein C levels; CESC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg05564831 chr3:52568323 NT5DC2 0.45 7.02 0.4 1.83e-11 Bipolar disorder; CESC trans rs11039798 0.764 rs11039771 chr11:48513273 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.15 0.35 2.89e-9 Axial length; CESC cis rs9513593 1.000 rs747848 chr13:100036182 C/T cg21788972 chr13:99853209 UBAC2 0.66 7.78 0.43 1.65e-13 Psoriasis; CESC cis rs8005677 1.000 rs2295685 chr14:23398153 A/G cg25600027 chr14:23388339 RBM23 -0.44 -5.37 -0.31 1.69e-7 Cognitive ability (multi-trait analysis); CESC cis rs7524258 0.868 rs916393 chr1:7272250 T/C cg07173049 chr1:7289937 CAMTA1 0.36 5.37 0.31 1.68e-7 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs6439153 0.933 rs810952 chr3:128685905 A/G cg24203234 chr3:128598194 ACAD9 0.41 5.3 0.31 2.41e-7 Pneumococcal bacteremia; CESC cis rs425277 0.583 rs925905 chr1:2044037 T/C cg23803603 chr1:2058230 PRKCZ -0.34 -5.99 -0.35 6.97e-9 Height; CESC cis rs6748734 0.901 rs6720357 chr2:241830296 A/C cg07537917 chr2:241836409 C2orf54 -0.25 -5.22 -0.31 3.59e-7 Urinary metabolites; CESC cis rs7648466 0.592 rs2087726 chr3:46208310 G/A cg08033130 chr3:45983597 CXCR6;FYCO1 0.37 5.16 0.3 4.77e-7 Eotaxin levels; CESC cis rs6701037 0.566 rs10489326 chr1:175134677 A/G cg00321850 chr1:175162397 KIAA0040 0.44 6.32 0.36 1.11e-9 Alcohol dependence; CESC cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg03146154 chr1:46216737 IPP -0.45 -5.58 -0.32 5.83e-8 High light scatter reticulocyte count; CESC cis rs10080237 0.564 rs2490232 chr6:80814802 C/T cg08355045 chr6:80787529 NA -0.33 -5.22 -0.31 3.67e-7 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; CESC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg00149659 chr3:10157352 C3orf10 0.71 9.04 0.49 3.46e-17 Alzheimer's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25421043 chr12:122124840 NA 0.49 7.18 0.4 7.16e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7296418 0.518 rs28825193 chr12:123878262 T/C cg00376283 chr12:123451042 ABCB9 0.57 7.49 0.42 1.04e-12 Platelet count; CESC cis rs2070677 0.935 rs12245318 chr10:135419483 A/G cg20169779 chr10:135381914 SYCE1 -0.73 -9.56 -0.51 8.51e-19 Gout; CESC cis rs7424096 0.582 rs7600245 chr2:37220614 A/C cg14987922 chr2:37194071 STRN 0.49 5.41 0.32 1.38e-7 High light scatter reticulocyte percentage of red cells; CESC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg06456125 chr7:65229604 NA -0.39 -5.37 -0.31 1.75e-7 Aortic root size; CESC cis rs7223966 1.000 rs8075257 chr17:61728750 G/C cg11494091 chr17:61959527 GH2 0.38 5.13 0.3 5.66e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs892961 1.000 rs2117924 chr17:75401310 C/T cg05865280 chr17:75406074 SEPT9 0.66 13.11 0.63 1.34e-30 Airflow obstruction; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg02374996 chr9:92220771 GADD45G -0.47 -6.18 -0.35 2.42e-9 Height; CESC cis rs72781680 0.560 rs111310684 chr2:24265682 C/G cg08917208 chr2:24149416 ATAD2B 0.63 6.09 0.35 3.87e-9 Lymphocyte counts; CESC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg04511125 chr2:88470314 THNSL2 -0.52 -7.71 -0.43 2.5e-13 Response to metformin (IC50); CESC trans rs11098499 0.604 rs2389886 chr4:120570422 C/T cg25214090 chr10:38739885 LOC399744 0.57 7.5 0.42 9.6e-13 Corneal astigmatism; CESC cis rs9640161 0.789 rs60283368 chr7:150023258 G/A cg10018233 chr7:150070692 REPIN1 0.45 7.37 0.41 2.21e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg27535305 chr1:53392650 SCP2 0.34 6.09 0.35 4e-9 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11948421 chr20:3451504 ATRN 0.61 6.72 0.38 1.11e-10 Gut microbiome composition (summer); CESC cis rs709400 0.965 rs861534 chr14:104168701 C/T cg12935359 chr14:103987150 CKB -0.39 -5.45 -0.32 1.17e-7 Body mass index; CESC cis rs4654899 0.680 rs4654881 chr1:21209769 T/C cg05370193 chr1:21551575 ECE1 -0.35 -5.31 -0.31 2.27e-7 Superior frontal gyrus grey matter volume; CESC cis rs919433 0.963 rs12469546 chr2:198178826 T/C cg03934865 chr2:198174659 NA -0.41 -5.5 -0.32 8.72e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.13 0.3 5.61e-7 Bipolar disorder; CESC cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg10523679 chr1:76189770 ACADM -0.7 -8.07 -0.44 2.39e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg03709012 chr19:19516395 GATAD2A 1.01 15.7 0.69 1.01e-39 Tonsillectomy; CESC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg27170947 chr2:26402098 FAM59B -0.6 -7.23 -0.41 5.28e-12 Gut microbiome composition (summer); CESC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg03264133 chr6:25882463 NA -0.56 -8.88 -0.48 1.05e-16 Blood metabolite levels; CESC cis rs12474201 0.832 rs4953419 chr2:46989869 T/G cg06386533 chr2:46925753 SOCS5 0.84 11.44 0.58 6.63e-25 Height; CESC cis rs16854884 0.657 rs6440210 chr3:143705763 A/G cg06585982 chr3:143692056 C3orf58 0.48 6.2 0.36 2.11e-9 Economic and political preferences (feminism/equality); CESC cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg11890956 chr21:40555474 PSMG1 1.09 18.23 0.75 1.15e-48 Cognitive function; CESC cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg06212747 chr3:49208901 KLHDC8B 0.68 9.36 0.5 3.59e-18 Parkinson's disease; CESC cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4889855 0.545 rs61171555 chr17:78465975 T/G cg00066239 chr17:78472159 NA -0.42 -5.74 -0.33 2.58e-8 Fractional excretion of uric acid; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26571926 chr1:8613145 RERE -0.53 -6.02 -0.35 5.9e-9 Gut microbiome composition (summer); CESC cis rs79349575 0.783 rs12601858 chr17:47017477 T/C cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.8 0.39 6.92e-11 Bipolar disorder; CESC trans rs7615952 0.641 rs61048217 chr3:125807905 G/T cg07211511 chr3:129823064 LOC729375 -0.56 -6.22 -0.36 1.92e-9 Blood pressure (smoking interaction); CESC cis rs6088590 1.000 rs6088615 chr20:33400474 C/T cg08999081 chr20:33150536 PIGU -0.55 -8.21 -0.45 1.01e-14 Coronary artery disease; CESC cis rs3106136 0.967 rs12499309 chr4:95171284 G/A cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.2 -0.4 6.38e-12 Capecitabine sensitivity; CESC cis rs4472734 0.965 rs12074811 chr1:214619102 C/A cg00063699 chr1:214624242 PTPN14 -0.34 -5.26 -0.31 2.93e-7 Height; CESC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg02221750 chr19:17393354 ANKLE1 -0.51 -6.24 -0.36 1.71e-9 Systemic lupus erythematosus; CESC cis rs2080501 0.601 rs3803665 chr16:49672520 A/G cg27618369 chr16:49636483 ZNF423 0.36 5.37 0.31 1.74e-7 IgG glycosylation; CESC cis rs6570726 0.791 rs9403730 chr6:145907233 C/T cg05347473 chr6:146136440 FBXO30 0.57 7.48 0.42 1.09e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs4820539 1.000 rs4822357 chr22:23473231 A/G cg14186256 chr22:23484241 RTDR1 0.73 11.91 0.59 1.75e-26 Bone mineral density; CESC cis rs765787 0.530 rs4444275 chr15:45535347 T/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg24578937 chr1:2090814 PRKCZ 0.34 6.14 0.35 3.05e-9 Height; CESC cis rs5769765 0.773 rs138861 chr22:50202276 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.5 -5.54 -0.32 7.4e-8 Schizophrenia; CESC cis rs1451375 0.583 rs11575320 chr7:50605298 A/G cg14593290 chr7:50529359 DDC -0.48 -5.9 -0.34 1.1e-8 Malaria; CESC cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.88 0.34 1.21e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.524 rs2242081 chr11:47500267 T/C cg20307385 chr11:47447363 PSMC3 0.64 8.73 0.47 2.86e-16 Subjective well-being; CESC cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg03433033 chr1:76189801 ACADM 0.68 8.05 0.44 2.87e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg18350739 chr11:68623251 NA 0.44 6.76 0.38 8.8e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2933343 0.729 rs1680794 chr3:128620390 A/G cg24203234 chr3:128598194 ACAD9 0.39 5.26 0.31 2.91e-7 IgG glycosylation; CESC cis rs6964587 1.000 rs10225885 chr7:91671007 A/G cg17063962 chr7:91808500 NA 0.58 7.99 0.44 4.22e-14 Breast cancer; CESC cis rs11190604 1.000 rs2495759 chr10:102320363 C/T cg07080220 chr10:102295463 HIF1AN 0.64 5.64 0.33 4.28e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs9814567 1.000 rs7611611 chr3:134307877 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.41 -5.52 -0.32 8.11e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs10883723 0.737 rs11191312 chr10:104278601 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.59 7.31 0.41 3.18e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg00255919 chr5:131827918 IRF1 -0.54 -9.13 -0.49 1.77e-17 Asthma (sex interaction); CESC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg02896835 chr1:92012615 NA -0.53 -6.82 -0.39 6.02e-11 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14645856 chr6:18368844 NA 0.48 6.28 0.36 1.38e-9 Fibrinogen levels; CESC cis rs1018836 0.564 rs7821994 chr8:91700916 C/T cg16814680 chr8:91681699 NA -0.96 -16.7 -0.72 2.78e-43 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg05347473 chr6:146136440 FBXO30 0.58 7.38 0.41 2.09e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs62229266 0.839 rs11702763 chr21:37470704 A/G cg08632701 chr21:37451849 NA -0.4 -5.33 -0.31 2.13e-7 Mitral valve prolapse; CESC cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg25019033 chr10:957182 NA -0.6 -6.19 -0.36 2.24e-9 Eosinophil percentage of granulocytes; CESC cis rs1823874 0.720 rs7162911 chr15:100355050 A/G cg16400843 chr15:100339927 C15orf51 0.3 5.26 0.31 3e-7 IgG glycosylation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00874357 chr12:62997129 MIRLET7I;C12orf61 0.49 6.34 0.36 1.01e-9 Gut microbiota (bacterial taxa); CESC cis rs5758659 0.653 rs133383 chr22:42473603 C/T cg05082376 chr22:42548792 NA -0.36 -5.21 -0.3 3.85e-7 Cognitive function; CESC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg04553112 chr3:125709451 NA -0.55 -5.85 -0.34 1.44e-8 Blood pressure (smoking interaction); CESC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg25838465 chr1:92012736 NA -0.58 -8.52 -0.46 1.21e-15 Breast cancer; CESC cis rs9790314 1.000 rs336593 chr3:161076431 T/C cg03342759 chr3:160939853 NMD3 -0.46 -6.03 -0.35 5.48e-9 Morning vs. evening chronotype; CESC trans rs3780486 0.718 rs3818593 chr9:33120706 A/G cg04842962 chr6:43655489 MRPS18A 0.74 8.74 0.47 2.66e-16 IgG glycosylation; CESC cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg18569988 chr3:195679450 NA 0.34 5.03 0.3 8.91e-7 Pancreatic cancer; CESC cis rs2439831 1.000 rs2253708 chr15:43797273 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.25 0.53 5.65e-21 Lung cancer in ever smokers; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19575813 chr18:46476937 SMAD7 -0.48 -6.55 -0.37 2.97e-10 Fibrinogen levels; CESC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg18904891 chr8:8559673 CLDN23 0.72 8.39 0.46 2.85e-15 Obesity-related traits; CESC cis rs6963495 0.818 rs73190184 chr7:105163736 C/T cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs7809950 0.593 rs62482503 chr7:106987988 A/G cg23024343 chr7:107201750 COG5 -0.53 -6.84 -0.39 5.49e-11 Coronary artery disease; CESC cis rs79349575 0.783 rs61576918 chr17:46985593 A/C cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 10.03 0.52 2.83e-20 Platelet count; CESC cis rs12545109 0.723 rs2610045 chr8:57413439 A/G cg09654669 chr8:57350985 NA 0.45 5.73 0.33 2.69e-8 Obesity-related traits; CESC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg02463440 chr8:22132932 PIWIL2 0.37 5.61 0.33 5.04e-8 Hypertriglyceridemia; CESC trans rs11098499 0.954 rs13151285 chr4:120314741 C/A cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.25 0.31 3.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4901869 0.966 rs60800733 chr14:59337778 A/G cg02291164 chr14:59296302 NA 0.45 7.73 0.43 2.21e-13 Panic disorder; CESC cis rs7927592 0.913 rs3740631 chr11:68341722 T/G cg20283391 chr11:68216788 NA -0.61 -7.29 -0.41 3.48e-12 Total body bone mineral density; CESC cis rs17253792 0.545 rs12894613 chr14:56016221 T/C cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18159533 chr12:133357242 GOLGA3 -0.54 -6.36 -0.36 8.77e-10 Gut microbiome composition (summer); CESC cis rs9658691 0.607 rs9658791 chr10:90777338 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.59 -5.06 -0.3 7.75e-7 Mosquito bite size; CESC cis rs752010 0.841 rs6661784 chr1:42080312 A/T cg06885757 chr1:42089581 HIVEP3 0.47 7.55 0.42 7.19e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs12545109 0.800 rs1440763 chr8:57410481 C/A cg09654669 chr8:57350985 NA -0.56 -6.65 -0.38 1.67e-10 Obesity-related traits; CESC cis rs9640161 0.750 rs3735169 chr7:150034378 A/G cg21361702 chr7:150065534 REPIN1 0.53 5.74 0.33 2.53e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg00484396 chr16:3507460 NAT15 0.62 7.98 0.44 4.51e-14 Tuberculosis; CESC cis rs17376456 0.877 rs10061080 chr5:93420559 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.32 0.31 2.19e-7 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13179880 chr1:46016123 AKR1A1 -0.48 -6.09 -0.35 3.98e-9 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg03188948 chr7:1209495 NA 0.7 6.78 0.38 7.86e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg04369109 chr6:150039330 LATS1 -0.36 -5.03 -0.3 9.02e-7 Lung cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09447457 chr6:24721528 NA -0.52 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs1018836 0.892 rs2187981 chr8:91549629 T/C cg16814680 chr8:91681699 NA -0.64 -9.06 -0.49 2.94e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2230307 0.536 rs687513 chr1:100598867 C/T cg24955406 chr1:100503596 HIAT1 -0.53 -5.43 -0.32 1.25e-7 Carotid intima media thickness; CESC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 12.86 0.62 9.89e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10788264 0.504 rs7069328 chr10:124030741 G/C cg09507567 chr10:124027408 NA 0.43 6.04 0.35 5.22e-9 Total body bone mineral density; CESC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg00149659 chr3:10157352 C3orf10 0.69 8.2 0.45 1.02e-14 Alzheimer's disease; CESC cis rs8072100 0.934 rs9905583 chr17:45741016 C/T cg08085267 chr17:45401833 C17orf57 -0.43 -5.73 -0.33 2.73e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2050392 0.590 rs685319 chr10:30719331 G/A cg25182066 chr10:30743637 MAP3K8 -0.46 -6.02 -0.35 5.85e-9 Inflammatory bowel disease; CESC cis rs3008870 0.958 rs34367328 chr1:67445321 T/C cg02640540 chr1:67518911 SLC35D1 -0.51 -5.58 -0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg24060327 chr5:131705240 SLC22A5 -0.64 -8.58 -0.47 8.34e-16 Blood metabolite levels; CESC cis rs807669 0.807 rs698422 chr22:19205826 A/T cg02655711 chr22:19163373 SLC25A1 0.54 7.95 0.44 5.46e-14 Metabolite levels; CESC cis rs710216 0.917 rs3754223 chr1:43419091 A/T cg22176566 chr1:43424700 SLC2A1 0.54 6.16 0.35 2.63e-9 Red cell distribution width; CESC cis rs10740039 0.729 rs6479728 chr10:62490801 A/G cg02922035 chr10:62493342 NA -0.45 -5.7 -0.33 3.16e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg13206674 chr6:150067644 NUP43 0.42 6.02 0.35 5.81e-9 Lung cancer; CESC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg00802000 chr16:706648 WDR90 -0.41 -6.26 -0.36 1.51e-9 Height; CESC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.43e-7 Life satisfaction; CESC cis rs12545109 0.800 rs2576599 chr8:57388410 G/A cg09654669 chr8:57350985 NA -0.55 -6.56 -0.37 2.84e-10 Obesity-related traits; CESC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg26850624 chr5:429559 AHRR -0.5 -6.67 -0.38 1.52e-10 Cystic fibrosis severity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08620789 chr7:157129638 DNAJB6 0.54 6.44 0.37 5.63e-10 Gut microbiome composition (summer); CESC cis rs6088580 0.634 rs6059868 chr20:33079460 A/G cg08999081 chr20:33150536 PIGU 0.66 11.75 0.59 6.14e-26 Glomerular filtration rate (creatinine); CESC cis rs7762018 1.000 rs17860606 chr6:170099561 G/A cg13891659 chr6:170190454 C6orf122;C6orf208 0.52 5.42 0.32 1.37e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg15664640 chr17:80829946 TBCD 0.61 8.98 0.48 5.23e-17 Breast cancer; CESC cis rs4862307 0.754 rs6846007 chr4:184991604 A/G cg06737308 chr4:185021514 ENPP6 -0.42 -5.76 -0.33 2.35e-8 Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs9457247 1.000 rs376574 chr6:167389956 A/T cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC cis rs595982 0.559 rs73061643 chr19:49368151 A/G cg15549821 chr19:49342101 PLEKHA4 -0.71 -7.96 -0.44 5.22e-14 Red cell distribution width; CESC cis rs763121 0.853 rs5757211 chr22:39051705 C/T cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00714078 chr2:135809744 RAB3GAP1 -0.44 -6.38 -0.36 7.98e-10 Asthma; CESC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg13206674 chr6:150067644 NUP43 0.42 5.9 0.34 1.13e-8 Lung cancer; CESC cis rs920590 0.758 rs17091534 chr8:19670651 C/T cg17834443 chr8:19674713 INTS10 0.55 6.17 0.35 2.57e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg02951883 chr7:2050386 MAD1L1 -0.48 -6.24 -0.36 1.73e-9 Bipolar disorder and schizophrenia; CESC cis rs9039 0.959 rs12925781 chr16:9216914 A/G cg08831531 chr16:9218945 NA 0.54 7.01 0.4 1.95e-11 Menopause (age at onset); CESC cis rs4132509 1.000 rs1458024 chr1:243937445 G/C cg21452805 chr1:244014465 NA 0.44 5.54 0.32 7.13e-8 RR interval (heart rate); CESC cis rs72781680 0.752 rs72796119 chr2:23917179 C/T cg20701182 chr2:24300061 SF3B14 0.79 6.88 0.39 4.25e-11 Lymphocyte counts; CESC cis rs11250464 0.833 rs2387653 chr10:1407826 A/G cg26394196 chr10:1453818 ADARB2 0.4 5.23 0.31 3.46e-7 Radiation response; CESC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9435341 0.965 rs1335055 chr1:107624563 A/G cg09367891 chr1:107599246 PRMT6 0.55 6.95 0.39 2.84e-11 Facial morphology (factor 21, depth of nasal alae); CESC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.75 -0.38 9.41e-11 Electroencephalogram traits; CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg18765753 chr7:1198926 ZFAND2A -0.5 -7.41 -0.41 1.66e-12 Longevity;Endometriosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27135125 chr7:23510082 IGF2BP3 -0.45 -6.19 -0.36 2.3e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2204008 0.692 rs11613378 chr12:38213138 T/A cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs7124681 0.528 rs74608150 chr11:47696214 A/T cg20307385 chr11:47447363 PSMC3 0.62 8.65 0.47 5.02e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs6963495 0.818 rs6956249 chr7:105149743 A/T cg19920283 chr7:105172520 RINT1 0.66 6.28 0.36 1.36e-9 Bipolar disorder (body mass index interaction); CESC cis rs11997175 0.595 rs7386404 chr8:33762842 T/C ch.8.33884649F chr8:33765107 NA 0.5 5.73 0.33 2.73e-8 Body mass index; CESC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg00933542 chr6:150070202 PCMT1 0.3 5.11 0.3 6.15e-7 Lung cancer; CESC trans rs1545843 0.564 rs2468284 chr12:84892620 A/C cg03015433 chr16:56623111 MT3 0.33 6.1 0.35 3.76e-9 Major depressive disorder; CESC cis rs864537 0.622 rs2949661 chr1:167424924 C/T cg09179987 chr1:167433047 CD247 0.54 7.88 0.44 8.5e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs4253772 0.550 rs9615949 chr22:46722531 C/T cg10541313 chr22:46663664 TTC38 0.64 5.09 0.3 6.86e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4722585 0.533 rs2237335 chr7:26200213 A/G cg07876897 chr7:26191696 NFE2L3 0.42 5.31 0.31 2.32e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); CESC cis rs2243480 1.000 rs427044 chr7:65508545 G/A cg12463550 chr7:65579703 CRCP 0.7 5.46 0.32 1.1e-7 Diabetic kidney disease; CESC cis rs6690583 0.573 rs75119114 chr1:85451385 A/C cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs17253792 0.822 rs112238223 chr14:56056144 C/A cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.62 0.33 4.81e-8 Putamen volume; CESC cis rs1728785 1.000 rs1615609 chr16:68596401 C/A cg02972257 chr16:68554789 NA -0.59 -6.72 -0.38 1.09e-10 Ulcerative colitis; CESC cis rs9399401 0.667 rs7757571 chr6:142702589 A/C cg03128060 chr6:142623767 GPR126 0.37 6.5 0.37 4e-10 Chronic obstructive pulmonary disease; CESC cis rs7131987 0.903 rs11050152 chr12:29404424 G/T cg09582351 chr12:29534625 ERGIC2 -0.36 -5.67 -0.33 3.66e-8 QT interval; CESC cis rs9611565 0.681 rs132918 chr22:41808350 C/T cg03806693 chr22:41940476 POLR3H 1.04 12.98 0.62 3.76e-30 Vitiligo; CESC trans rs453301 0.624 rs330058 chr8:9089809 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -6.7 -0.38 1.24e-10 Joint mobility (Beighton score); CESC cis rs10242455 0.571 rs55830753 chr7:99292222 A/G cg07338983 chr7:99679036 ZNF3 0.68 5.13 0.3 5.49e-7 Blood metabolite levels; CESC cis rs7084402 0.967 rs1649033 chr10:60279634 T/C cg07615347 chr10:60278583 BICC1 -0.58 -9.28 -0.5 6.18e-18 Refractive error; CESC cis rs4900538 0.963 rs1190553 chr14:102915331 G/T cg18135206 chr14:102964638 TECPR2 -0.78 -10.28 -0.53 4.49e-21 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs17685 0.753 rs3757593 chr7:75678735 G/A cg19862616 chr7:65841803 NCRNA00174 -0.84 -12.47 -0.61 2.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs11190604 1.000 rs7073586 chr10:102307671 A/G cg07080220 chr10:102295463 HIF1AN 0.58 5.89 0.34 1.2e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg00255919 chr5:131827918 IRF1 0.51 8.68 0.47 4.19e-16 Asthma (sex interaction); CESC cis rs7078219 0.543 rs7095491 chr10:101274058 A/G cg09788492 chr10:101292477 NKX2-3 0.32 6.04 0.35 5.1e-9 Dental caries; CESC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4835473 0.932 rs35277115 chr4:144656154 T/C cg25736465 chr4:144833511 NA -0.34 -5.45 -0.32 1.15e-7 Immature fraction of reticulocytes; CESC cis rs7762018 0.607 rs75999653 chr6:170066927 A/G cg15199489 chr6:170068458 WDR27 0.68 5.2 0.3 4.03e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs12541635 0.677 rs4734892 chr8:106990088 G/C cg10147462 chr8:107024639 NA 0.43 6.38 0.37 7.67e-10 Age of smoking initiation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09312446 chr16:2051647 ZNF598 0.5 6.74 0.38 9.81e-11 Fibrinogen levels; CESC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg27170947 chr2:26402098 FAM59B -0.53 -6.74 -0.38 1.01e-10 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg25036284 chr2:26402008 FAM59B 0.72 8.26 0.45 7.04e-15 Gut microbiome composition (summer); CESC cis rs6500395 0.962 rs9941336 chr16:48652769 G/A cg04672837 chr16:48644449 N4BP1 0.47 5.57 0.32 6.4e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2180341 0.618 rs11961994 chr6:127649350 A/G cg27446573 chr6:127587934 RNF146 -0.61 -8.27 -0.45 6.54e-15 Breast cancer; CESC cis rs2625529 0.652 rs2957745 chr15:72288077 T/C cg16672083 chr15:72433130 SENP8 0.41 6.31 0.36 1.18e-9 Red blood cell count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18050295 chr3:12949921 IQSEC1 0.49 6.46 0.37 4.86e-10 Fibrinogen levels; CESC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg18301423 chr5:131593218 PDLIM4 0.38 5.5 0.32 8.83e-8 Acylcarnitine levels; CESC cis rs870825 0.616 rs28579226 chr4:185650458 A/C cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.74e-11 Blood protein levels; CESC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg24675658 chr1:53192096 ZYG11B -0.55 -6.86 -0.39 4.79e-11 Monocyte count; CESC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.62 8.86 0.48 1.22e-16 Bipolar disorder; CESC cis rs10979 0.964 rs9321922 chr6:143895231 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs9403521 1.000 rs6907410 chr6:143995142 A/G cg21026257 chr6:143998961 PHACTR2 0.47 5.2 0.3 4e-7 Obesity-related traits; CESC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg12963246 chr6:28129442 ZNF389 0.54 7.12 0.4 1.02e-11 Depression; CESC cis rs10870270 1.000 rs9971066 chr10:133788233 G/A cg17892150 chr10:133769511 PPP2R2D -0.86 -12.51 -0.61 1.56e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs712039 0.652 rs829163 chr17:35766026 G/C cg16670864 chr17:35848621 DUSP14 0.44 5.48 0.32 9.81e-8 Tuberculosis; CESC cis rs698813 0.604 rs12712916 chr2:44482099 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.33 0.31 2.12e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs4835473 0.900 rs34772566 chr4:144655508 G/A cg25736465 chr4:144833511 NA -0.33 -5.15 -0.3 5.08e-7 Immature fraction of reticulocytes; CESC cis rs1843834 0.539 rs6749402 chr2:225443901 T/G cg22509189 chr2:225307070 NA -0.42 -5.63 -0.33 4.6e-8 IgE levels in asthmatics (D.p. specific); CESC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9303542 0.559 rs2326012 chr17:46618581 C/T cg04904318 chr17:46607828 HOXB1 -0.54 -5.39 -0.31 1.54e-7 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs9902453 0.689 rs7216948 chr17:28203173 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 9.14 0.49 1.74e-17 Coffee consumption (cups per day); CESC cis rs7116495 0.609 rs7126394 chr11:71685429 A/G cg10381502 chr11:71823885 C11orf51 -1.18 -7.75 -0.43 1.95e-13 Severe influenza A (H1N1) infection; CESC cis rs826838 1.000 rs4768328 chr12:39129315 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs2290159 0.800 rs57884385 chr3:12673551 G/C cg23032965 chr3:12705835 RAF1 0.53 5.68 0.33 3.63e-8 Cholesterol, total; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05599930 chr11:119252487 USP2 -0.48 -6.55 -0.37 3.04e-10 Fibrinogen levels; CESC cis rs7833986 0.501 rs2719258 chr8:56941389 C/T cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.27 0.31 2.81e-7 Height; CESC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg22963979 chr7:1858916 MAD1L1 0.38 5.31 0.31 2.36e-7 Bipolar disorder and schizophrenia; CESC cis rs2243480 1.000 rs4718316 chr7:65648731 A/G cg13147721 chr7:65941812 NA 0.97 9.16 0.49 1.47e-17 Diabetic kidney disease; CESC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.27 0.41 4.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg18180107 chr4:99064573 C4orf37 0.48 5.84 0.34 1.5e-8 Colonoscopy-negative controls vs population controls; CESC cis rs734999 0.588 rs6689711 chr1:2531467 T/C cg20673091 chr1:2541236 MMEL1 -0.43 -7.12 -0.4 1.03e-11 Ulcerative colitis; CESC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg10691866 chr7:65817282 TPST1 0.33 5.23 0.31 3.45e-7 Aortic root size; CESC trans rs4349753 0.663 rs28626847 chr5:144089514 C/T cg22407458 chr6:35109121 TCP11 0.5 6.22 0.36 1.94e-9 Photic sneeze reflex; CESC cis rs9457247 1.000 rs415890 chr6:167406633 C/G cg23791538 chr6:167370224 RNASET2 0.6 8.45 0.46 1.92e-15 Crohn's disease; CESC cis rs34779708 0.733 rs12240638 chr10:35542610 G/T cg04310649 chr10:35416472 CREM -0.47 -5.39 -0.31 1.59e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs9858542 1.000 rs4283605 chr3:49678651 A/G cg07274523 chr3:49395745 GPX1 0.67 8.46 0.46 1.87e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg22823121 chr1:150693482 HORMAD1 0.44 6.07 0.35 4.39e-9 Melanoma; CESC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg22903471 chr2:27725779 GCKR -0.5 -7.22 -0.41 5.42e-12 Total body bone mineral density; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07241146 chr10:134145514 LRRC27 -0.45 -6.05 -0.35 4.9e-9 Asthma; CESC cis rs881375 0.678 rs10118357 chr9:123680068 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.16 0.4 7.88e-12 Rheumatoid arthritis; CESC cis rs4474465 0.688 rs7945812 chr11:78280509 T/C cg01578073 chr11:78285783 NARS2 -0.44 -5.1 -0.3 6.33e-7 Alzheimer's disease (survival time); CESC cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg24308560 chr3:49941425 MST1R -0.63 -9.23 -0.49 8.99e-18 Intelligence (multi-trait analysis); CESC cis rs8005677 0.798 rs4982713 chr14:23404102 C/T cg01529538 chr14:23388837 RBM23 0.43 5.69 0.33 3.3e-8 Cognitive ability (multi-trait analysis); CESC cis rs1949733 0.656 rs2688243 chr4:8436286 A/G cg11789530 chr4:8429930 ACOX3 0.76 10.53 0.54 7.02e-22 Response to antineoplastic agents; CESC cis rs11690935 0.550 rs62183769 chr2:172838074 A/C cg13550731 chr2:172543902 DYNC1I2 0.5 6.86 0.39 4.72e-11 Schizophrenia; CESC cis rs4594175 0.926 rs10145287 chr14:51626808 G/T cg23942311 chr14:51606299 NA 0.35 5.26 0.31 2.93e-7 Cancer; CESC cis rs7918232 0.782 rs7910168 chr10:27465296 G/A cg14442939 chr10:27389572 ANKRD26 0.69 6.91 0.39 3.51e-11 Breast cancer; CESC cis rs9308731 0.568 rs28723045 chr2:111935698 T/G cg04202892 chr2:111875749 ACOXL 0.38 5.27 0.31 2.76e-7 Chronic lymphocytic leukemia; CESC cis rs7208859 0.623 rs55638872 chr17:29149552 G/C cg19761014 chr17:28927070 LRRC37B2 0.79 6.47 0.37 4.6e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg10845886 chr2:3471009 TTC15 -0.68 -9.43 -0.5 2.13e-18 Neurofibrillary tangles; CESC cis rs1915146 0.546 rs2681919 chr10:126859029 A/G cg00406319 chr10:126851303 NA 0.37 5.78 0.33 2.05e-8 Menarche (age at onset); CESC cis rs763121 0.752 rs5757222 chr22:39060473 C/T cg06022373 chr22:39101656 GTPBP1 0.88 13.88 0.65 2.66e-33 Menopause (age at onset); CESC cis rs11098499 0.954 rs6847248 chr4:120225955 A/G cg09307838 chr4:120376055 NA 0.9 11.64 0.58 1.49e-25 Corneal astigmatism; CESC cis rs7089973 0.525 rs11196945 chr10:116600424 G/A cg23260525 chr10:116636907 FAM160B1 0.4 7.2 0.4 6.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg02574844 chr11:5959923 NA -0.44 -5.57 -0.32 6.18e-8 DNA methylation (variation); CESC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg14393609 chr7:65229607 NA 0.53 7.07 0.4 1.34e-11 Calcium levels; CESC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg20307385 chr11:47447363 PSMC3 -0.64 -7.7 -0.43 2.65e-13 Subjective well-being; CESC cis rs7116495 0.609 rs7113436 chr11:71689599 A/T cg10381502 chr11:71823885 C11orf51 1.18 7.06 0.4 1.45e-11 Severe influenza A (H1N1) infection; CESC cis rs60843830 0.661 rs6755432 chr2:106692 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.52 6.19 0.36 2.26e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs901683 1.000 rs17157884 chr10:46015942 C/T cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.42 -6.95 -0.39 2.78e-11 Personality dimensions; CESC cis rs1707322 0.752 rs28890893 chr1:46186576 T/G cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs589249 0.637 rs906227 chr1:37189396 C/T cg19869746 chr6:7107108 RREB1 0.44 6.0 0.35 6.61e-9 Neuroticism (multi-trait analysis);Schizophrenia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02894226 chr20:3190561 ITPA 0.45 6.2 0.36 2.14e-9 Systemic lupus erythematosus; CESC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg27266027 chr21:40555129 PSMG1 0.46 5.51 0.32 8.65e-8 Cognitive function; CESC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.39 0.31 1.56e-7 Bipolar disorder; CESC cis rs8067545 0.611 rs2703803 chr17:20107069 G/T cg13482628 chr17:19912719 NA -0.42 -5.7 -0.33 3.18e-8 Schizophrenia; CESC cis rs2274273 0.662 rs66476033 chr14:55660863 C/A cg04306507 chr14:55594613 LGALS3 0.31 5.27 0.31 2.78e-7 Protein biomarker; CESC cis rs9837602 0.938 rs1021341 chr3:99786289 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.44 6.65 0.38 1.69e-10 Breast cancer; CESC cis rs1881797 1.000 rs12061460 chr1:247686787 G/A cg05639522 chr1:247681581 NA 0.46 6.02 0.35 5.84e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs9611519 0.754 rs4820435 chr22:41652846 G/T cg17376030 chr22:41985996 PMM1 0.5 5.55 0.32 7.02e-8 Neuroticism; CESC cis rs11190604 1.000 rs10883511 chr10:102299407 A/G cg07080220 chr10:102295463 HIF1AN 0.68 6.34 0.36 9.76e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs10089 1.000 rs6595800 chr5:127411647 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.34 0.54 2.74e-21 Ileal carcinoids; CESC cis rs12995491 0.933 rs13008732 chr2:88528771 G/A cg07952391 chr2:88470173 THNSL2 -0.55 -8.32 -0.46 4.66e-15 Response to metformin (IC50); CESC cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.51 0.37 3.77e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2204008 0.837 rs55962152 chr12:38234281 G/A cg13010199 chr12:38710504 ALG10B 0.49 6.15 0.35 2.82e-9 Bladder cancer; CESC cis rs4711336 1.000 rs2296742 chr6:33659793 G/A cg14003231 chr6:33640908 ITPR3 0.32 5.42 0.32 1.34e-7 Height; CESC cis rs12618769 0.597 rs56197140 chr2:99113740 T/C cg10123293 chr2:99228465 UNC50 0.41 5.44 0.32 1.24e-7 Bipolar disorder; CESC cis rs478304 0.651 rs11604462 chr11:65551648 G/A cg27068330 chr11:65405492 SIPA1 -0.46 -5.55 -0.32 6.83e-8 Acne (severe); CESC cis rs77216612 1.000 rs77216612 chr12:12877983 A/G cg04607235 chr12:12878440 APOLD1 -1.05 -16.25 -0.71 1.17e-41 Lymphocyte counts; CESC cis rs4867766 0.871 rs11747479 chr5:173955389 C/T cg20434911 chr5:173954559 NA -0.6 -6.57 -0.37 2.66e-10 Stroke; CESC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.87e-8 Lung cancer; CESC cis rs2952156 0.959 rs2941503 chr17:37828745 A/G cg07936489 chr17:37558343 FBXL20 -0.52 -6.24 -0.36 1.72e-9 Asthma; CESC trans rs208520 0.608 rs3846803 chr6:66805743 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.78 -0.62 1.78e-29 Exhaled nitric oxide output; CESC cis rs5753037 0.702 rs81800 chr22:30200362 C/G cg01021169 chr22:30184971 ASCC2 0.47 6.6 0.38 2.28e-10 Type 1 diabetes; CESC cis rs7520050 0.966 rs12411269 chr1:46271052 C/T cg03146154 chr1:46216737 IPP -0.47 -6.19 -0.36 2.34e-9 Red blood cell count;Reticulocyte count; CESC cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.65 7.47 0.42 1.15e-12 Age-related macular degeneration (geographic atrophy); CESC cis rs8067354 0.872 rs2645488 chr17:57889405 T/G cg13753209 chr17:57696993 CLTC 0.5 6.83 0.39 5.83e-11 Hemoglobin concentration; CESC cis rs4253772 0.530 rs79354880 chr22:46746419 C/A cg18190219 chr22:46762943 CELSR1 -0.68 -6.23 -0.36 1.85e-9 LDL cholesterol;Cholesterol, total; CESC cis rs1005277 0.540 rs2145487 chr10:38010077 A/G cg25427524 chr10:38739819 LOC399744 -0.64 -9.44 -0.5 1.98e-18 Extrinsic epigenetic age acceleration; CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg04025307 chr7:1156635 C7orf50 0.57 9.81 0.52 1.4e-19 Longevity;Endometriosis; CESC cis rs78889164 0.592 rs1423066 chr19:33850667 T/C cg02272751 chr19:33882848 PEPD -0.37 -5.48 -0.32 9.97e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs4808199 0.947 rs2163804 chr19:19575965 G/A cg03709012 chr19:19516395 GATAD2A 1.17 13.38 0.63 1.53e-31 Nonalcoholic fatty liver disease; CESC cis rs7937682 0.855 rs7934922 chr11:111500026 T/C cg22437258 chr11:111473054 SIK2 0.7 9.18 0.49 1.31e-17 Primary sclerosing cholangitis; CESC cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg26516362 chr5:178986906 RUFY1 0.41 6.02 0.35 5.78e-9 Lung cancer; CESC cis rs60871478 0.787 rs4720928 chr7:808002 T/C cg27478167 chr7:817139 HEATR2 -0.46 -5.41 -0.32 1.39e-7 Cerebrospinal P-tau181p levels; CESC cis rs4835473 0.932 rs4597770 chr4:144656392 C/A cg25736465 chr4:144833511 NA -0.33 -5.3 -0.31 2.48e-7 Immature fraction of reticulocytes; CESC cis rs4727027 0.804 rs13231262 chr7:148886058 C/T cg23583168 chr7:148888333 NA -0.87 -13.55 -0.64 3.91e-32 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg08859206 chr1:53392774 SCP2 -0.61 -8.9 -0.48 9.3e-17 Monocyte count; CESC trans rs12599106 0.707 rs2163977 chr16:34916134 A/G cg21548813 chr6:291882 DUSP22 -0.71 -9.4 -0.5 2.71e-18 Menopause (age at onset); CESC trans rs11088226 0.681 rs2833901 chr21:33939318 T/C cg09050820 chr6:167586206 TCP10L2 0.84 7.8 0.43 1.41e-13 Gastritis; CESC cis rs8028182 0.636 rs11636199 chr15:75825337 A/G cg20655648 chr15:75932815 IMP3 0.5 6.25 0.36 1.66e-9 Sudden cardiac arrest; CESC cis rs2415984 0.622 rs1761025 chr14:46930439 T/C cg14871534 chr14:47121158 RPL10L 0.36 5.52 0.32 7.98e-8 Number of children ever born; CESC cis rs4975709 0.569 rs931509 chr5:1858821 A/T cg10800226 chr5:1850261 NA 0.36 5.72 0.33 2.93e-8 Cardiovascular disease risk factors; CESC cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg23711669 chr6:146136114 FBXO30 -0.96 -14.73 -0.67 2.74e-36 Lobe attachment (rater-scored or self-reported); CESC trans rs1728785 1.000 rs11647432 chr16:68565426 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg01448562 chr3:133502909 NA -0.41 -5.78 -0.33 2.04e-8 Iron status biomarkers; CESC cis rs2637266 0.703 rs11001859 chr10:78464869 G/C cg18941641 chr10:78392320 NA 0.38 6.86 0.39 4.82e-11 Pulmonary function; CESC trans rs7246657 0.891 rs7253114 chr19:37988725 G/A cg01833234 chr11:6592585 DNHD1 0.52 6.16 0.35 2.73e-9 Coronary artery calcification; CESC cis rs7178572 0.633 rs12900004 chr15:77844904 A/G cg22256960 chr15:77711686 NA -0.48 -6.12 -0.35 3.32e-9 Type 2 diabetes; CESC cis rs12956009 0.518 rs3889651 chr18:44865012 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.73 0.38 1.02e-10 Educational attainment (years of education); CESC cis rs4727027 0.899 rs11768971 chr7:148825826 C/G cg23583168 chr7:148888333 NA -0.79 -12.21 -0.6 1.63e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6701037 1.000 rs7512413 chr1:175124789 C/T cg00321850 chr1:175162397 KIAA0040 -0.42 -5.88 -0.34 1.22e-8 Alcohol dependence; CESC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg06420487 chr17:61919686 SMARCD2 0.45 5.39 0.31 1.56e-7 Height; CESC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg11644478 chr21:40555479 PSMG1 -0.52 -7.02 -0.4 1.82e-11 Menarche (age at onset); CESC cis rs12620999 0.774 rs13402764 chr2:237951984 C/T cg23555395 chr2:238036564 NA -0.47 -6.25 -0.36 1.66e-9 Systemic lupus erythematosus; CESC cis rs1030877 0.515 rs2679895 chr2:105906480 C/G cg02079111 chr2:105885981 TGFBRAP1 0.47 6.18 0.36 2.35e-9 Obesity-related traits; CESC cis rs1499972 0.938 rs817509 chr3:117750861 A/G cg07612923 chr3:117604196 NA -0.79 -5.81 -0.34 1.75e-8 Schizophrenia; CESC cis rs2191566 0.576 rs396148 chr19:44494548 A/T cg20607764 chr19:44506953 ZNF230 0.45 5.71 0.33 2.96e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs1468333 0.592 rs217272 chr5:137486426 A/G cg27119451 chr5:137514611 BRD8;KIF20A 0.49 5.2 0.3 3.96e-7 Resting heart rate; CESC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 1.000 rs7778911 chr7:65694506 T/C cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs10484885 0.690 rs292236 chr6:90528422 A/G cg13799429 chr6:90582589 CASP8AP2 -0.85 -9.71 -0.51 2.91e-19 QRS interval (sulfonylurea treatment interaction); CESC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg06873352 chr17:61820015 STRADA 0.45 6.73 0.38 1.03e-10 Height; CESC cis rs2404602 0.647 rs2404600 chr15:77173557 C/T cg06336613 chr15:77223807 RCN2 0.4 5.07 0.3 7.56e-7 Blood metabolite levels; CESC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg22800045 chr5:56110881 MAP3K1 -0.44 -5.4 -0.31 1.48e-7 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16280946 chr22:20716554 NA -0.47 -6.34 -0.36 1.01e-9 Gut microbiota (bacterial taxa); CESC trans rs1814175 0.708 rs10839464 chr11:49981386 T/C cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg05861140 chr6:150128134 PCMT1 -0.35 -5.07 -0.3 7.48e-7 Lung cancer; CESC cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg18527119 chr7:66119851 NA 0.46 5.09 0.3 6.71e-7 Aortic root size; CESC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 11.77 0.59 5.23e-26 Alzheimer's disease; CESC cis rs17253792 0.732 rs8017891 chr14:56172967 A/G cg01858014 chr14:56050164 KTN1 0.61 5.55 0.32 7e-8 Putamen volume; CESC cis rs6084875 0.733 rs6037959 chr20:4741723 A/G cg05143360 chr20:4741328 NA 0.54 7.39 0.41 1.89e-12 Systemic lupus erythematosus; CESC cis rs10504229 0.679 rs1596142 chr8:58032406 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -5.93 -0.34 9.43e-9 Developmental language disorder (linguistic errors); CESC cis rs2404602 0.684 rs8029283 chr15:76837140 A/G cg23625390 chr15:77176239 SCAPER -0.44 -6.09 -0.35 3.98e-9 Blood metabolite levels; CESC cis rs9811920 0.515 rs792836 chr3:99476384 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.33 -5.42 -0.32 1.37e-7 Axial length; CESC cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg24110177 chr3:50126178 RBM5 0.54 7.58 0.42 5.85e-13 Intelligence (multi-trait analysis); CESC cis rs12477438 0.953 rs3851334 chr2:99794704 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.67 -7.85 -0.43 1.06e-13 Chronic sinus infection; CESC cis rs8017423 0.904 rs12433417 chr14:90804028 A/G cg14092571 chr14:90743983 NA 0.57 8.86 0.48 1.18e-16 Mortality in heart failure; CESC cis rs7927771 1.000 rs7947730 chr11:47786184 C/T cg18512352 chr11:47633146 NA -0.61 -9.64 -0.51 4.87e-19 Subjective well-being; CESC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg22535103 chr8:58192502 C8orf71 -0.94 -9.92 -0.52 6.44e-20 Developmental language disorder (linguistic errors); CESC cis rs17376456 0.877 rs7728736 chr5:93404277 C/T cg21475434 chr5:93447410 FAM172A 0.8 7.26 0.41 4.26e-12 Diabetic retinopathy; CESC cis rs8062405 0.964 rs11860513 chr16:28825420 C/T cg08761264 chr16:28874980 SH2B1 -0.47 -5.86 -0.34 1.34e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg11247378 chr22:39784982 NA 0.6 9.06 0.49 2.94e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1215050 0.755 rs6843393 chr4:98822619 C/G cg05340658 chr4:99064831 C4orf37 0.51 6.58 0.37 2.5e-10 Waist-to-hip ratio adjusted for body mass index; CESC trans rs2727020 0.587 rs1164658 chr11:49298551 C/A cg03929089 chr4:120376271 NA 0.78 11.91 0.59 1.83e-26 Coronary artery disease; CESC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg21238619 chr17:78079768 GAA -0.37 -5.92 -0.34 1.01e-8 Yeast infection; CESC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.61 -8.36 -0.46 3.54e-15 Total body bone mineral density; CESC cis rs4148883 0.651 rs2851301 chr4:100010127 C/T cg12011299 chr4:100065546 ADH4 0.66 9.57 0.51 7.76e-19 Alcohol dependence; CESC cis rs1832871 0.672 rs13437296 chr6:158762819 A/C cg07165851 chr6:158734300 TULP4 0.58 6.19 0.36 2.31e-9 Height; CESC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.87 9.07 0.49 2.8e-17 Platelet count; CESC cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9399137 0.507 rs4896128 chr6:135349756 A/G cg24558204 chr6:135376177 HBS1L -0.67 -9.51 -0.5 1.18e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg00129232 chr17:37814104 STARD3 -0.55 -6.96 -0.39 2.68e-11 Glomerular filtration rate (creatinine); CESC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg10691866 chr7:65817282 TPST1 0.33 5.62 0.33 4.91e-8 Aortic root size; CESC cis rs6089584 0.545 rs6089578 chr20:60554636 G/T cg24733560 chr20:60626293 TAF4 0.42 6.12 0.35 3.33e-9 Body mass index; CESC cis rs12950390 0.853 rs17773010 chr17:45858297 C/T cg00777063 chr17:45855553 NA -0.39 -5.77 -0.33 2.26e-8 IgG glycosylation; CESC cis rs950169 1.000 rs1911155 chr15:84787635 A/G cg17507749 chr15:85114479 UBE2QP1 0.61 6.67 0.38 1.53e-10 Schizophrenia; CESC cis rs6460942 0.915 rs62448600 chr7:12454944 T/G cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC cis rs1355223 0.867 rs1377495 chr11:34682962 A/C cg11058730 chr11:34937778 PDHX;APIP 0.46 5.96 0.34 7.99e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg26081025 chr14:92570361 ATXN3 0.42 6.17 0.35 2.58e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs910316 0.789 rs175457 chr14:75584507 C/T cg08847533 chr14:75593920 NEK9 -0.9 -15.66 -0.69 1.36e-39 Height; CESC cis rs7520050 0.931 rs6697557 chr1:46307809 G/A cg24296786 chr1:45957014 TESK2 0.42 5.39 0.31 1.6e-7 Red blood cell count;Reticulocyte count; CESC cis rs9290065 0.519 rs956447 chr3:160668917 G/C cg03342759 chr3:160939853 NMD3 -0.42 -5.45 -0.32 1.15e-7 Kawasaki disease; CESC cis rs807669 0.500 rs5746668 chr22:19149151 T/G cg02655711 chr22:19163373 SLC25A1 0.57 6.72 0.38 1.08e-10 Metabolite levels; CESC cis rs17376456 0.877 rs17083455 chr5:93446380 A/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.57 5.08 0.3 7.18e-7 Diabetic retinopathy; CESC cis rs7208859 0.573 rs11654035 chr17:29136426 T/C cg19761014 chr17:28927070 LRRC37B2 0.78 6.27 0.36 1.45e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2228479 0.702 rs62056100 chr16:89939753 C/T cg00800038 chr16:89945340 TCF25 -0.95 -7.79 -0.43 1.48e-13 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02161084 chr15:73989526 CD276 -0.53 -6.42 -0.37 6.18e-10 Gut microbiome composition (summer); CESC cis rs2882667 0.858 rs11957633 chr5:138364394 T/C cg04439458 chr5:138467593 SIL1 -0.4 -6.21 -0.36 2.06e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7940866 0.838 rs10750455 chr11:130800330 C/T cg14779329 chr11:130786720 SNX19 0.34 5.2 0.3 4.02e-7 Schizophrenia; CESC cis rs16854884 0.584 rs2164554 chr3:143755528 A/G cg06585982 chr3:143692056 C3orf58 0.47 5.86 0.34 1.34e-8 Economic and political preferences (feminism/equality); CESC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg08859206 chr1:53392774 SCP2 0.6 7.73 0.43 2.28e-13 Monocyte count; CESC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.53 -0.51 1.05e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10883723 0.641 rs80146619 chr10:104405850 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.57 5.93 0.34 9.56e-9 Allergic disease (asthma, hay fever or eczema); CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg05064044 chr6:292385 DUSP22 -0.65 -8.13 -0.45 1.64e-14 Menopause (age at onset); CESC cis rs921968 0.565 rs6757772 chr2:219618497 T/G cg02176678 chr2:219576539 TTLL4 -0.43 -7.65 -0.43 3.63e-13 Mean corpuscular hemoglobin concentration; CESC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg26338869 chr17:61819248 STRADA 0.67 8.78 0.47 2.04e-16 Prudent dietary pattern; CESC cis rs1215050 0.791 rs2865943 chr4:98778449 C/T cg05340658 chr4:99064831 C4orf37 0.52 6.69 0.38 1.3e-10 Waist-to-hip ratio adjusted for body mass index; CESC trans rs17772222 0.740 rs28493481 chr14:88977835 G/T cg16524936 chr4:1340807 KIAA1530 -0.5 -6.01 -0.35 5.96e-9 Coronary artery calcification; CESC cis rs6088590 0.735 rs2273684 chr20:33529766 G/T cg08999081 chr20:33150536 PIGU -0.52 -8.12 -0.45 1.74e-14 Coronary artery disease; CESC cis rs5753618 0.583 rs8141150 chr22:31800336 C/T cg02404636 chr22:31891804 SFI1 0.41 5.6 0.33 5.36e-8 Colorectal cancer; CESC cis rs12898370 0.651 rs11634056 chr15:77539914 G/A cg17802220 chr15:77601643 NA -0.55 -6.03 -0.35 5.51e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg12373951 chr3:133503437 NA 0.5 7.22 0.41 5.64e-12 Iron status biomarkers; CESC cis rs2197308 0.692 rs1904964 chr12:37933241 T/A cg26384229 chr12:38710491 ALG10B 0.71 10.58 0.54 4.86e-22 Morning vs. evening chronotype; CESC cis rs6582630 0.502 rs10880092 chr12:38262965 A/T cg26384229 chr12:38710491 ALG10B 0.72 10.17 0.53 1.01e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg16325326 chr1:53192061 ZYG11B -1.0 -17.81 -0.74 3.35e-47 Monocyte count; CESC cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg14345882 chr6:26364793 BTN3A2 0.41 5.12 0.3 5.89e-7 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13643966 chr4:124036498 SPATA5 0.55 7.39 0.41 1.88e-12 Fibrinogen levels; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg21871583 chr3:15374148 SH3BP5 -0.4 -6.43 -0.37 5.8e-10 Breast cancer; CESC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg08470875 chr2:26401718 FAM59B -0.47 -5.05 -0.3 8.27e-7 Gut microbiome composition (summer); CESC cis rs1728785 1.000 rs1749791 chr16:68572347 C/T cg02972257 chr16:68554789 NA -0.55 -6.34 -0.36 9.7e-10 Ulcerative colitis; CESC cis rs4423214 1.000 rs12790010 chr11:71170653 T/C cg05163923 chr11:71159392 DHCR7 0.78 10.34 0.54 2.91e-21 Vitamin D levels; CESC cis rs2120019 1.000 rs12898259 chr15:75369780 G/A cg17294928 chr15:75287854 SCAMP5 -0.59 -6.65 -0.38 1.64e-10 Blood trace element (Zn levels); CESC cis rs10911232 0.507 rs4652764 chr1:182994115 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.2 0.63 6.49e-31 Hypertriglyceridemia; CESC cis rs67311347 1.000 rs9854493 chr3:40423622 T/C cg24209194 chr3:40518798 ZNF619 0.49 6.05 0.35 5e-9 Renal cell carcinoma; CESC cis rs2011503 1.000 rs4808951 chr19:19550306 C/G cg11584989 chr19:19387371 SF4 0.62 7.22 0.41 5.54e-12 Bipolar disorder; CESC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg18252515 chr7:66147081 NA -0.46 -6.05 -0.35 5e-9 Aortic root size; CESC cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg03060546 chr3:49711283 APEH 0.55 6.66 0.38 1.6e-10 Parkinson's disease; CESC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.63 0.42 4.35e-13 Prudent dietary pattern; CESC cis rs3824867 0.920 rs7105122 chr11:47449544 A/G cg20307385 chr11:47447363 PSMC3 0.48 5.68 0.33 3.5e-8 Mean corpuscular hemoglobin; CESC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg07648498 chr16:89883185 FANCA 0.49 6.19 0.36 2.28e-9 Vitiligo; CESC cis rs3806843 1.000 rs3756342 chr5:140165624 G/A cg26395211 chr5:140044315 WDR55 -0.42 -5.43 -0.32 1.26e-7 Depressive symptoms (multi-trait analysis); CESC cis rs3768617 0.510 rs1413390 chr1:183096634 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg10295955 chr4:187884368 NA -1.04 -20.81 -0.79 1.12e-57 Lobe attachment (rater-scored or self-reported); CESC cis rs2404602 0.655 rs8028294 chr15:77084877 T/C cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC cis rs7551222 0.752 rs35270244 chr1:204548416 A/C cg20240347 chr1:204465584 NA -0.27 -5.51 -0.32 8.41e-8 Schizophrenia; CESC trans rs123509 0.913 rs121993 chr3:42776601 T/C cg22035501 chr5:112073398 APC 0.57 6.07 0.35 4.49e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2456568 0.802 rs1108910 chr11:93629677 C/T cg26875233 chr11:93583750 C11orf90 0.3 5.31 0.31 2.27e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs400736 0.729 rs9434949 chr1:8006083 C/G cg25007680 chr1:8021821 PARK7 -0.57 -7.77 -0.43 1.68e-13 Response to antidepressants and depression; CESC cis rs7927771 0.832 rs7105851 chr11:47383275 T/C cg20307385 chr11:47447363 PSMC3 0.61 7.28 0.41 3.78e-12 Subjective well-being; CESC cis rs10242455 0.702 rs73713531 chr7:99222379 C/T cg25640893 chr7:99214727 ZNF498 0.73 5.11 0.3 6.08e-7 Blood metabolite levels; CESC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg10541313 chr22:46663664 TTC38 0.65 5.13 0.3 5.65e-7 LDL cholesterol;Cholesterol, total; CESC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg26039829 chr8:22132926 PIWIL2 0.38 5.84 0.34 1.52e-8 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04951051 chr10:79601860 DLG5 -0.48 -5.99 -0.35 6.68e-9 Gut microbiome composition (summer); CESC cis rs7824557 0.628 rs7841394 chr8:11185671 G/T cg21775007 chr8:11205619 TDH 0.52 8.04 0.44 3.07e-14 Retinal vascular caliber; CESC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg14558114 chr2:88469736 THNSL2 0.57 5.4 0.31 1.5e-7 Plasma clusterin levels; CESC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs2066819 0.892 rs77415512 chr12:56627300 A/G cg26714650 chr12:56694279 CS -1.53 -10.32 -0.54 3.19e-21 Psoriasis vulgaris; CESC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg09699651 chr6:150184138 LRP11 0.39 5.04 0.3 8.69e-7 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26796727 chr8:145634724 CPSF1 0.6 7.1 0.4 1.12e-11 Gut microbiome composition (summer); CESC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.55 -7.05 -0.4 1.58e-11 Alzheimer's disease; CESC cis rs17253792 0.822 rs58569951 chr14:56152245 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.7 5.41 0.32 1.39e-7 Putamen volume; CESC cis rs11166629 1.000 rs966659 chr8:135639045 C/T cg21672855 chr8:135614777 ZFAT -0.4 -5.13 -0.3 5.49e-7 Smoking quantity; CESC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.51 -5.61 -0.33 5.08e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26193882 chr7:74489851 WBSCR16 0.51 6.03 0.35 5.62e-9 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27397625 chr6:42952298 PPP2R5D -0.47 -6.98 -0.39 2.31e-11 Gambling; CESC cis rs13118159 0.641 rs4974598 chr4:1313220 C/T cg20887711 chr4:1340912 KIAA1530 0.56 7.79 0.43 1.56e-13 Longevity; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26207357 chr2:190539199 NA 0.49 6.4 0.37 6.97e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg22800045 chr5:56110881 MAP3K1 0.59 7.76 0.43 1.86e-13 Initial pursuit acceleration; CESC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 8.39 0.46 2.91e-15 Bipolar disorder; CESC trans rs1814175 0.645 rs28436748 chr11:50046422 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -18.7 -0.75 2.39e-50 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07466433 chr2:7005728 CMPK2 0.56 6.63 0.38 1.93e-10 Gut microbiome composition (summer); CESC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg22907277 chr7:1156413 C7orf50 0.42 5.95 0.34 8.56e-9 Longevity;Endometriosis; CESC cis rs854765 0.547 rs6502633 chr17:17941037 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.63 8.89 0.48 9.49e-17 Total body bone mineral density; CESC cis rs9457247 1.000 rs1819333 chr6:167373547 G/T cg25258033 chr6:167368657 RNASET2 0.43 6.47 0.37 4.84e-10 Crohn's disease; CESC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg25405998 chr7:65216604 CCT6P1 -0.45 -5.06 -0.3 7.71e-7 Aortic root size; CESC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -10.95 -0.56 2.97e-23 Extrinsic epigenetic age acceleration; CESC cis rs1775715 0.737 rs2778661 chr10:32159191 C/T cg18675610 chr10:32216311 ARHGAP12 0.35 5.4 0.32 1.45e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21026086 chr20:42939820 FITM2 0.61 7.05 0.4 1.51e-11 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03951180 chr7:72742151 TRIM50;FKBP6 0.47 7.06 0.4 1.48e-11 Fibrinogen levels; CESC cis rs3749237 0.595 rs4855873 chr3:49459114 A/C cg07636037 chr3:49044803 WDR6 0.62 9.09 0.49 2.43e-17 Resting heart rate; CESC cis rs76419734 0.558 rs3796920 chr4:106544526 A/G cg24545054 chr4:106630052 GSTCD;INTS12 0.53 5.15 0.3 5.01e-7 Post bronchodilator FEV1; CESC cis rs992157 0.710 rs10167446 chr2:219056866 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.64 8.73 0.47 2.94e-16 Colorectal cancer; CESC cis rs11122272 0.735 rs2486741 chr1:231516450 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13704629 chr14:73396469 DCAF4 -0.56 -6.28 -0.36 1.42e-9 Gut microbiome composition (summer); CESC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg11663144 chr21:46675770 NA -0.63 -9.84 -0.52 1.12e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9611565 0.592 rs9611612 chr22:41961189 T/C cg06634786 chr22:41940651 POLR3H -0.62 -6.84 -0.39 5.38e-11 Vitiligo; CESC cis rs782590 0.738 rs4312532 chr2:55812061 A/G cg18811423 chr2:55921094 PNPT1 -0.67 -10.16 -0.53 1.06e-20 Metabolic syndrome; CESC cis rs6693567 0.565 rs698913 chr1:150299145 G/A cg09579323 chr1:150459698 TARS2 0.49 6.28 0.36 1.35e-9 Migraine; CESC cis rs4835473 0.838 rs34521499 chr4:144698781 T/C cg25736465 chr4:144833511 NA -0.42 -6.42 -0.37 6.21e-10 Immature fraction of reticulocytes; CESC cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg18016565 chr1:150552671 MCL1 -0.42 -6.96 -0.39 2.64e-11 Tonsillectomy; CESC trans rs4073582 0.595 rs555360 chr11:65960061 T/C cg12039611 chr1:156786653 NTRK1;SH2D2A 0.34 6.07 0.35 4.37e-9 Gout; CESC cis rs3947 0.789 rs9009 chr8:11702006 A/T cg00262122 chr8:11665843 FDFT1 0.52 6.13 0.35 3.11e-9 Blood protein levels; CESC trans rs6054906 0.710 rs6117744 chr20:7265038 A/C cg21220336 chr9:79008793 RFK 0.46 6.28 0.36 1.36e-9 Response to amphetamines; CESC cis rs9911578 1.000 rs2531729 chr17:56539890 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.41 5.52 0.32 7.9e-8 Intelligence (multi-trait analysis); CESC cis rs10752881 1.000 rs10797812 chr1:182984597 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.85 -13.34 -0.63 2.02e-31 Colorectal cancer; CESC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg02018176 chr4:1364513 KIAA1530 0.44 6.28 0.36 1.41e-9 Longevity; CESC cis rs9902453 0.967 rs12449783 chr17:28527653 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.7 0.43 2.63e-13 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00242597 chr9:19380425 RPS6 -0.66 -8.0 -0.44 3.88e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00990212 chr12:6641042 NCAPD2 -0.65 -8.24 -0.45 8.17e-15 Gut microbiome composition (summer); CESC cis rs703842 0.964 rs10431552 chr12:58178148 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.73 9.5 0.5 1.32e-18 Multiple sclerosis; CESC cis rs3924048 0.574 rs11121928 chr1:12615888 C/G cg00291366 chr1:12616550 NA 0.4 7.21 0.4 5.88e-12 Optic cup area; CESC cis rs17428076 0.831 rs55957712 chr2:172587956 C/T cg13550731 chr2:172543902 DYNC1I2 0.47 5.3 0.31 2.48e-7 Myopia; CESC cis rs7301826 1.000 rs1609985 chr12:131320170 A/G cg11011512 chr12:131303247 STX2 0.42 5.23 0.31 3.48e-7 Plasma plasminogen activator levels; CESC cis rs7193541 0.564 rs4888274 chr16:74706298 A/T cg01733217 chr16:74700730 RFWD3 1.04 20.73 0.79 2.17e-57 Multiple myeloma; CESC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg26335602 chr6:28129616 ZNF389 0.5 6.14 0.35 2.97e-9 Parkinson's disease; CESC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 9.59 0.51 6.99e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6541297 0.703 rs586712 chr1:230315242 A/G cg20703242 chr1:230279135 GALNT2 -0.43 -5.62 -0.33 4.84e-8 Coronary artery disease; CESC cis rs7927592 0.956 rs948315 chr11:68309140 T/C cg16797656 chr11:68205561 LRP5 0.4 5.59 0.32 5.55e-8 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13491959 chr9:139292811 SNAPC4 0.53 7.86 0.43 9.69e-14 Fibrinogen levels; CESC cis rs2249625 0.967 rs4510633 chr6:72924275 A/G cg18830697 chr6:72922368 RIMS1 -0.43 -6.16 -0.35 2.68e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs2404618 0.624 rs28439223 chr8:1476901 C/G cg13402656 chr8:1511478 DLGAP2 -0.51 -7.04 -0.4 1.65e-11 Lung cancer; CESC cis rs7216064 1.000 rs4271626 chr17:65930133 G/A cg12091567 chr17:66097778 LOC651250 -0.75 -7.69 -0.43 2.84e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4803468 1.000 rs2241708 chr19:41912270 C/T cg14132834 chr19:41945861 ATP5SL -0.57 -7.03 -0.4 1.7e-11 Height; CESC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg02807482 chr3:125708958 NA -0.4 -5.17 -0.3 4.73e-7 Blood pressure (smoking interaction); CESC cis rs9911578 1.000 rs2531732 chr17:56548420 T/A cg12560992 chr17:57184187 TRIM37 -0.92 -15.31 -0.69 2.4e-38 Intelligence (multi-trait analysis); CESC cis rs62432291 0.681 rs420137 chr6:159652931 G/C cg14500486 chr6:159655392 FNDC1 -0.61 -6.04 -0.35 5.2e-9 Joint mobility (Beighton score); CESC trans rs4665809 1.000 rs6546767 chr2:26328746 A/G cg09258813 chr8:37823409 ADRB3 -0.37 -6.1 -0.35 3.65e-9 Gut microbiome composition (summer); CESC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg22433210 chr17:43662623 NA 0.96 10.7 0.55 1.87e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs13191362 0.507 rs13211655 chr6:163177542 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.49 5.52 0.32 8.21e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9457247 0.765 rs9459836 chr6:167419105 G/A cg23791538 chr6:167370224 RNASET2 -0.54 -7.48 -0.42 1.1e-12 Crohn's disease; CESC cis rs116095464 0.558 rs28635197 chr5:279071 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.77e-15 Breast cancer; CESC cis rs11209002 0.567 rs2224501 chr1:67532526 G/T cg02640540 chr1:67518911 SLC35D1 0.48 5.47 0.32 1.04e-7 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21249729 chr9:138392748 C9orf116;MRPS2 0.56 6.58 0.37 2.52e-10 Gut microbiome composition (summer); CESC cis rs10191773 0.589 rs11676628 chr2:112953355 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 0.68 6.78 0.38 7.87e-11 Yeast infection; CESC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg06028808 chr11:68637592 NA 0.48 5.73 0.33 2.68e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3106136 0.546 rs2664880 chr4:95144177 T/A cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Capecitabine sensitivity; CESC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg10053473 chr17:62856997 LRRC37A3 0.65 7.43 0.42 1.5e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16373769 chr10:30024815 SVIL -0.47 -6.43 -0.37 5.95e-10 Fibrinogen levels; CESC cis rs7216064 0.953 rs75231441 chr17:65885485 A/G cg07042672 chr17:66097459 LOC651250 -0.52 -5.4 -0.31 1.5e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7223966 1.000 rs16947042 chr17:61766457 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.63 0.42 4.2e-13 Hip circumference adjusted for BMI;Body mass index; CESC cis rs67311347 1.000 rs2371186 chr3:40488713 G/C cg09455208 chr3:40491958 NA 0.49 8.04 0.44 2.91e-14 Renal cell carcinoma; CESC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg06481639 chr22:41940642 POLR3H -0.58 -5.78 -0.33 2.11e-8 Vitiligo; CESC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg22433210 chr17:43662623 NA 0.99 11.09 0.56 9.69e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg24562669 chr7:97807699 LMTK2 0.48 6.92 0.39 3.3e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg14393609 chr7:65229607 NA -0.45 -6.02 -0.35 5.91e-9 Aortic root size; CESC cis rs6537837 0.793 rs17575742 chr1:110083603 C/A cg05049280 chr1:110155535 GNAT2 0.38 5.3 0.31 2.45e-7 Major depressive disorder; CESC cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg21573476 chr21:45109991 RRP1B -0.53 -8.0 -0.44 3.92e-14 Mean corpuscular volume; CESC cis rs10752881 1.000 rs10737237 chr1:182989269 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.31 0.63 2.66e-31 Colorectal cancer; CESC cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg04455712 chr21:45112962 RRP1B -0.49 -7.81 -0.43 1.33e-13 Mean corpuscular volume; CESC cis rs959260 1.000 rs4789186 chr17:73386086 C/T cg12999837 chr17:73267436 MIF4GD -0.51 -5.74 -0.33 2.57e-8 Systemic lupus erythematosus; CESC cis rs1372520 0.684 rs2619368 chr4:90729747 T/G cg15133208 chr4:90757351 SNCA -0.43 -5.79 -0.33 2.02e-8 Neuroticism; CESC cis rs6835098 0.924 rs13125240 chr4:174151619 T/C cg08422745 chr4:174089978 GALNT7 0.71 9.0 0.48 4.41e-17 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs7640424 0.649 rs6795280 chr3:107876232 T/C cg09227934 chr3:107805635 CD47 -0.44 -5.67 -0.33 3.75e-8 Body mass index; CESC cis rs782590 0.935 rs10460508 chr2:55882565 A/C cg18811423 chr2:55921094 PNPT1 0.79 12.9 0.62 6.94e-30 Metabolic syndrome; CESC cis rs8077577 0.671 rs4925178 chr17:18252911 T/C cg16794390 chr17:18148240 FLII 0.38 6.25 0.36 1.59e-9 Obesity-related traits; CESC cis rs881375 0.967 rs1014529 chr9:123684943 C/G cg00246817 chr9:123691163 NA -0.41 -5.05 -0.3 8.25e-7 Rheumatoid arthritis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15420520 chr20:55043481 C20orf43 -0.47 -6.01 -0.35 6.19e-9 Ulcerative colitis; CESC cis rs8180040 0.764 rs12630534 chr3:47001043 T/C cg27129171 chr3:47204927 SETD2 0.66 9.69 0.51 3.31e-19 Colorectal cancer; CESC cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.85e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg22974920 chr21:40686053 BRWD1 -0.46 -5.59 -0.32 5.73e-8 Cognitive function; CESC cis rs2404602 0.684 rs965818 chr15:76866785 T/C cg23625390 chr15:77176239 SCAPER -0.42 -5.74 -0.33 2.53e-8 Blood metabolite levels; CESC cis rs2637266 0.703 rs35654095 chr10:78472016 C/T cg18941641 chr10:78392320 NA 0.4 7.3 0.41 3.46e-12 Pulmonary function; CESC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg22433210 chr17:43662623 NA 0.98 11.39 0.57 9.63e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2120019 1.000 rs67544533 chr15:75361539 A/G cg17294928 chr15:75287854 SCAMP5 -0.67 -7.47 -0.42 1.19e-12 Blood trace element (Zn levels); CESC cis rs6964587 0.967 rs17164315 chr7:91659150 C/G cg17063962 chr7:91808500 NA 0.57 7.86 0.43 9.58e-14 Breast cancer; CESC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1048257 0.553 rs2819421 chr14:105408811 A/G cg17340268 chr14:105411764 AHNAK2 -0.51 -6.7 -0.38 1.22e-10 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26877631 chr10:21823297 MLLT10 -0.56 -6.47 -0.37 4.65e-10 Gut microbiome composition (summer); CESC cis rs9811920 0.609 rs793467 chr3:99539664 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 9.5 0.5 1.33e-18 Axial length; CESC cis rs6728642 1.000 rs17037402 chr2:98014883 C/T cg26665480 chr2:98280029 ACTR1B -0.88 -6.29 -0.36 1.29e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg26441486 chr22:50317300 CRELD2 -0.4 -5.16 -0.3 4.95e-7 Schizophrenia; CESC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg16325326 chr1:53192061 ZYG11B -0.79 -13.18 -0.63 7.46e-31 Monocyte count; CESC cis rs6964587 0.839 rs6949881 chr7:91433827 C/T cg17063962 chr7:91808500 NA 0.51 6.55 0.37 2.99e-10 Breast cancer; CESC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg17376030 chr22:41985996 PMM1 -0.78 -8.33 -0.46 4.43e-15 Vitiligo; CESC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg24675658 chr1:53192096 ZYG11B -0.48 -6.0 -0.35 6.49e-9 Monocyte count; CESC trans rs116095464 0.558 rs9312978 chr5:221930 C/G cg00938859 chr5:1591904 SDHAP3 0.66 6.24 0.36 1.72e-9 Breast cancer; CESC cis rs910316 0.967 rs2024653 chr14:75595154 G/A cg08847533 chr14:75593920 NEK9 0.99 18.93 0.76 3.76e-51 Height; CESC cis rs1124376 1.000 rs11712709 chr3:20139777 G/C cg05072819 chr3:20081367 KAT2B 0.54 5.93 0.34 9.47e-9 Bipolar disorder and schizophrenia; CESC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg08704250 chr15:31115839 NA -0.56 -7.37 -0.41 2.12e-12 Huntington's disease progression; CESC cis rs4074961 0.565 rs10908362 chr1:38061706 G/C cg13401533 chr1:37979913 MEAF6 0.43 5.45 0.32 1.13e-7 Axial length; CESC cis rs11997175 0.574 rs12541661 chr8:33649856 T/G ch.8.33884649F chr8:33765107 NA 0.65 8.33 0.46 4.44e-15 Body mass index; CESC cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg25517755 chr10:38738941 LOC399744 -0.47 -6.04 -0.35 5.12e-9 Extrinsic epigenetic age acceleration; CESC trans rs773506 0.565 rs4354431 chr9:94109406 T/A cg02954284 chr22:21367447 MGC16703 0.35 6.27 0.36 1.44e-9 Type 2 diabetes nephropathy; CESC cis rs4604732 0.603 rs4546958 chr1:247639478 G/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.38 0.31 1.63e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7937682 0.924 rs489783 chr11:111520522 A/G cg22437258 chr11:111473054 SIK2 0.7 9.35 0.5 3.83e-18 Primary sclerosing cholangitis; CESC cis rs2228479 0.850 rs79244293 chr16:89896220 T/C cg00800038 chr16:89945340 TCF25 -0.85 -6.5 -0.37 3.94e-10 Skin colour saturation; CESC cis rs10089 1.000 rs3805612 chr5:127505316 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.09 0.53 1.74e-20 Ileal carcinoids; CESC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg23758822 chr17:41437982 NA 1.05 15.6 0.69 2.24e-39 Menopause (age at onset); CESC cis rs2228479 0.681 rs7196840 chr16:89959647 A/G cg04013166 chr16:89971882 TCF25 0.72 8.84 0.48 1.39e-16 Skin colour saturation; CESC cis rs8114671 0.562 rs6088653 chr20:33520321 T/C cg06115741 chr20:33292138 TP53INP2 0.46 5.58 0.32 6.06e-8 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17546822 chr22:41865178 ACO2;PHF5A 0.51 7.61 0.42 4.86e-13 Gut microbiota (bacterial taxa); CESC cis rs7659604 0.702 rs61217486 chr4:122693973 T/C cg20573242 chr4:122745356 CCNA2 0.52 6.45 0.37 5.41e-10 Type 2 diabetes; CESC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs9815354 0.812 rs73073364 chr3:41843058 T/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs6089829 0.962 rs2872543 chr20:61665017 G/A cg23505145 chr19:12996616 KLF1 0.52 6.71 0.38 1.15e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs7587476 0.784 rs62202001 chr2:215690359 C/G cg04004882 chr2:215674386 BARD1 0.53 5.91 0.34 1.05e-8 Neuroblastoma; CESC cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg15556689 chr8:8085844 FLJ10661 0.41 5.04 0.3 8.76e-7 Mood instability; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08156809 chr7:74071310 GTF2I -0.5 -6.56 -0.37 2.81e-10 Ulcerative colitis; CESC cis rs654950 0.875 rs2810550 chr1:41995339 T/C cg06885757 chr1:42089581 HIVEP3 -0.44 -6.82 -0.39 6.21e-11 Airway imaging phenotypes; CESC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.47 0.32 1.06e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg17372223 chr3:52568218 NT5DC2 0.56 9.68 0.51 3.68e-19 Electroencephalogram traits; CESC cis rs2656056 1 rs2656056 chr15:78722519 T/C cg24631222 chr15:78858424 CHRNA5 -0.6 -6.99 -0.39 2.2e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg22907277 chr7:1156413 C7orf50 0.42 5.86 0.34 1.38e-8 Longevity;Endometriosis; CESC cis rs721399 0.719 rs4646257 chr8:18262546 A/G cg18736775 chr8:18248649 NAT2 0.47 5.07 0.3 7.41e-7 Blood metabolite levels; CESC cis rs67478160 0.595 rs2295146 chr14:104199356 C/T cg08213375 chr14:104286397 PPP1R13B 0.47 8.87 0.48 1.12e-16 Schizophrenia; CESC cis rs116095464 0.558 rs62347678 chr5:227496 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.44 0.32 1.19e-7 Breast cancer; CESC cis rs79387448 0.810 rs76229479 chr2:103123912 A/C cg09003973 chr2:102972529 NA 0.79 6.08 0.35 4.17e-9 Gut microbiota (bacterial taxa); CESC cis rs4594175 0.926 rs11624975 chr14:51628347 T/C cg23942311 chr14:51606299 NA 0.36 5.43 0.32 1.28e-7 Cancer; CESC cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg07697082 chr8:82753677 SNX16 0.37 5.07 0.3 7.36e-7 Diastolic blood pressure; CESC cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg05347473 chr6:146136440 FBXO30 0.65 8.13 0.45 1.63e-14 Lobe attachment (rater-scored or self-reported); CESC trans rs1814175 0.645 rs7928714 chr11:49887622 G/A cg15704280 chr7:45808275 SEPT13 -0.98 -18.32 -0.75 5.46e-49 Height; CESC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg05368731 chr17:41323189 NBR1 0.79 10.65 0.55 2.72e-22 Menopause (age at onset); CESC cis rs72781680 1.000 rs56068891 chr2:24230633 A/G cg08917208 chr2:24149416 ATAD2B 1.13 9.83 0.52 1.17e-19 Lymphocyte counts; CESC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg14926445 chr8:58193284 C8orf71 -0.53 -5.69 -0.33 3.33e-8 Developmental language disorder (linguistic errors); CESC cis rs7267979 1.000 rs2257808 chr20:25266450 G/C cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9291683 0.530 rs4235346 chr4:9945296 C/T cg11266682 chr4:10021025 SLC2A9 -0.63 -12.73 -0.62 2.68e-29 Bone mineral density; CESC cis rs1983891 0.779 rs4714475 chr6:41509901 G/T cg20194872 chr6:41519635 FOXP4 0.58 8.23 0.45 8.38e-15 Prostate cancer; CESC cis rs2282802 0.685 rs13359519 chr5:139654664 G/A cg26211634 chr5:139558579 C5orf32 0.51 7.37 0.41 2.24e-12 Intelligence (multi-trait analysis); CESC cis rs6502050 0.805 rs4789740 chr17:80119202 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.56 -0.37 2.88e-10 Life satisfaction; CESC trans rs11098499 0.954 rs10006706 chr4:120409152 A/G cg25214090 chr10:38739885 LOC399744 0.69 9.49 0.5 1.38e-18 Corneal astigmatism; CESC cis rs72627123 0.867 rs8020310 chr14:74494437 A/G cg08255017 chr14:74727001 VSX2 0.58 5.23 0.31 3.37e-7 Morning vs. evening chronotype; CESC cis rs7223966 1.000 rs2854218 chr17:61942940 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 5.77 0.33 2.16e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs926938 0.765 rs1884296 chr1:115235716 A/C cg12756093 chr1:115239321 AMPD1 -0.64 -9.93 -0.52 5.96e-20 Autism; CESC cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg12927641 chr6:109611667 NA -0.41 -6.43 -0.37 5.98e-10 Reticulocyte fraction of red cells; CESC cis rs2228479 0.850 rs17227057 chr16:89816333 C/T cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs10465746 0.746 rs12749350 chr1:84456948 T/A cg10977910 chr1:84465055 TTLL7 0.52 7.13 0.4 9.47e-12 Obesity-related traits; CESC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg08859206 chr1:53392774 SCP2 -0.66 -9.71 -0.51 2.99e-19 Monocyte count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04578738 chr17:34136331 TAF15 0.48 6.31 0.36 1.16e-9 Gut microbiota (bacterial taxa); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07389500 chr5:137681244 FAM53C 0.47 6.18 0.35 2.46e-9 Fibrinogen levels; CESC cis rs2414059 0.518 rs3098171 chr15:50771511 C/G cg05456662 chr15:50716270 USP8 -0.41 -5.44 -0.32 1.2e-7 QT interval; CESC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg12963246 chr6:28129442 ZNF389 -0.55 -7.32 -0.41 3.05e-12 Parkinson's disease; CESC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg23758822 chr17:41437982 NA 1.02 14.96 0.68 4.21e-37 Menopause (age at onset); CESC cis rs3820068 0.603 rs7536654 chr1:15989141 C/G cg17385448 chr1:15911702 AGMAT 0.44 7.64 0.42 3.91e-13 Systolic blood pressure; CESC cis rs62432291 0.681 rs417719 chr6:159658042 C/T cg14500486 chr6:159655392 FNDC1 -0.61 -6.2 -0.36 2.19e-9 Joint mobility (Beighton score); CESC cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg18512352 chr11:47633146 NA -0.6 -9.05 -0.49 3.14e-17 Subjective well-being; CESC cis rs1003719 0.680 rs2835664 chr21:38573429 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.58e-15 Eye color traits; CESC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg00129232 chr17:37814104 STARD3 0.56 7.28 0.41 3.73e-12 Glomerular filtration rate (creatinine); CESC cis rs7267979 0.903 rs6115101 chr20:25229564 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.1 0.68 1.39e-37 Liver enzyme levels (alkaline phosphatase); CESC cis rs3857067 1.000 rs1397025 chr4:95018987 G/T cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs7927771 1.000 rs7120333 chr11:47817441 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -6.04 -0.35 5.24e-9 Subjective well-being; CESC cis rs4843747 0.749 rs72818535 chr16:88074039 G/A cg06374794 chr16:88002281 BANP 0.41 5.39 0.31 1.57e-7 Menopause (age at onset); CESC cis rs11255400 0.590 rs12412852 chr10:7999085 A/G cg12123470 chr10:7215341 SFMBT2 -0.55 -5.36 -0.31 1.84e-7 IgG glycosylation; CESC cis rs1348850 0.632 rs4470372 chr2:178505857 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 7.59 0.42 5.54e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg20573242 chr4:122745356 CCNA2 0.66 8.08 0.44 2.34e-14 Type 2 diabetes; CESC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.76 0.38 8.8e-11 Bipolar disorder; CESC cis rs2070677 0.935 rs7907312 chr10:135417364 A/G cg20169779 chr10:135381914 SYCE1 -0.74 -9.71 -0.51 2.99e-19 Gout; CESC cis rs9915657 0.870 rs720244 chr17:70131643 G/T cg06234051 chr17:70120541 SOX9 -0.47 -6.85 -0.39 5.21e-11 Thyroid hormone levels; CESC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg03609598 chr5:56110824 MAP3K1 -0.49 -5.23 -0.31 3.48e-7 Initial pursuit acceleration; CESC cis rs1152591 0.967 rs1152589 chr14:64683926 A/T cg23250157 chr14:64679961 SYNE2 -0.56 -8.2 -0.45 1.06e-14 Atrial fibrillation; CESC cis rs7216064 0.953 rs11871285 chr17:65840809 G/T cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.73e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1215050 0.740 rs1084784 chr4:98961711 T/G cg05340658 chr4:99064831 C4orf37 -0.56 -7.54 -0.42 7.65e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4595586 0.546 rs10876163 chr12:39244915 G/A cg13010199 chr12:38710504 ALG10B 0.56 7.54 0.42 7.63e-13 Morning vs. evening chronotype; CESC cis rs36051895 0.632 rs62541958 chr9:5175621 T/C cg02405213 chr9:5042618 JAK2 -0.48 -5.5 -0.32 8.93e-8 Pediatric autoimmune diseases; CESC cis rs9457247 1.000 rs2769347 chr6:167371737 T/A cg25258033 chr6:167368657 RNASET2 -0.41 -6.22 -0.36 1.98e-9 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12133393 chr1:3816695 C1orf174;LOC100133612 0.58 6.78 0.38 7.65e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.15e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2832191 0.740 rs2832177 chr21:30478353 G/A cg24692254 chr21:30365293 RNF160 -0.99 -17.21 -0.73 4.35e-45 Dental caries; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26156301 chr20:30193024 ID1 -0.48 -6.24 -0.36 1.68e-9 Fibrinogen levels; CESC cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg15556689 chr8:8085844 FLJ10661 0.49 5.83 0.34 1.6e-8 Systolic blood pressure; CESC cis rs858239 0.539 rs10270695 chr7:23188988 C/T cg23682824 chr7:23144976 KLHL7 -0.52 -6.87 -0.39 4.48e-11 Cerebrospinal fluid biomarker levels; CESC trans rs1493916 0.967 rs1389532 chr18:31392323 C/T cg27147174 chr7:100797783 AP1S1 -0.52 -7.04 -0.4 1.62e-11 Life satisfaction; CESC cis rs796364 1.000 rs281763 chr2:200794870 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.83 8.38 0.46 3.17e-15 Schizophrenia; CESC cis rs6942756 1.000 rs7806089 chr7:128972215 C/G cg02491457 chr7:128862824 NA -0.67 -9.07 -0.49 2.72e-17 White matter hyperintensity burden; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12141744 chr12:34319939 NA -0.44 -6.03 -0.35 5.48e-9 Gut microbiota (bacterial taxa); CESC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.04 -0.56 1.41e-23 Alzheimer's disease; CESC cis rs8050907 0.744 rs11862204 chr16:4519586 G/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs17539620 0.624 rs4566892 chr6:154837346 C/T cg17771515 chr6:154831774 CNKSR3 0.59 5.85 0.34 1.43e-8 Lipoprotein (a) levels; CESC cis rs66573146 1.000 rs6812771 chr4:6964048 G/A cg00086871 chr4:6988644 TBC1D14 1.16 6.56 0.37 2.82e-10 Granulocyte percentage of myeloid white cells; CESC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg05861140 chr6:150128134 PCMT1 -0.38 -5.43 -0.32 1.29e-7 Lung cancer; CESC cis rs539096 0.566 rs3011220 chr1:44308867 A/G cg12908607 chr1:44402522 ARTN -0.48 -7.19 -0.4 6.6e-12 Intelligence (multi-trait analysis); CESC cis rs7249921 0.833 rs62111373 chr19:35660844 G/C cg15419183 chr19:35660584 FXYD5 0.56 8.42 0.46 2.36e-15 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19188060 chr3:184017239 PSMD2 0.55 6.1 0.35 3.7e-9 Gut microbiome composition (summer); CESC cis rs920590 0.758 rs7011322 chr8:19661937 C/T cg17834443 chr8:19674713 INTS10 0.58 6.53 0.37 3.27e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.2e-17 Prudent dietary pattern; CESC cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg10556349 chr10:835070 NA 0.56 5.44 0.32 1.19e-7 Eosinophil percentage of granulocytes; CESC cis rs8038465 0.615 rs11072430 chr15:73981701 A/G cg15420318 chr15:73925796 NPTN -0.47 -6.96 -0.39 2.72e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3008870 0.755 rs12562761 chr1:67396739 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.64 8.31 0.45 5e-15 Lymphocyte percentage of white cells; CESC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.91 -13.32 -0.63 2.41e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2777491 0.957 rs1757454 chr15:41777934 A/G cg02330683 chr15:41787940 ITPKA 0.49 7.24 0.41 4.75e-12 Ulcerative colitis; CESC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg21724239 chr8:58056113 NA 0.57 5.76 0.33 2.29e-8 Developmental language disorder (linguistic errors); CESC cis rs6594713 0.602 rs33992630 chr5:112903169 G/A cg12552261 chr5:112820674 MCC 0.55 5.45 0.32 1.15e-7 Brain cytoarchitecture; CESC cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg18402987 chr7:1209562 NA 0.47 5.35 0.31 1.93e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg09491104 chr22:46646882 C22orf40 -0.49 -5.92 -0.34 9.8e-9 LDL cholesterol;Cholesterol, total; CESC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.43 0.5 2.2e-18 Menopause (age at onset); CESC cis rs8050907 0.744 rs8047271 chr16:4536634 A/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.75 5.31 0.31 2.32e-7 Obesity-related traits; CESC cis rs9291683 0.609 rs34709913 chr4:10028955 T/C cg00071950 chr4:10020882 SLC2A9 0.9 16.44 0.71 2.41e-42 Bone mineral density; CESC cis rs6762 0.550 rs8672 chr11:838634 C/G cg07691484 chr11:842764 TSPAN4;POLR2L -0.67 -8.9 -0.48 8.91e-17 Mean platelet volume; CESC cis rs7949030 0.653 rs2516634 chr11:62367186 G/A cg13298116 chr11:62369859 EML3;MTA2 -0.61 -9.03 -0.48 3.75e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs8038465 1.000 rs8032531 chr15:73977271 A/G cg15420318 chr15:73925796 NPTN 0.44 6.23 0.36 1.85e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs17854409 0.764 rs73613593 chr20:61471582 T/C cg05147244 chr20:61493195 TCFL5 1.11 5.94 0.34 9.08e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09266924 chr15:29034669 NA -0.54 -6.44 -0.37 5.66e-10 Gut microbiome composition (summer); CESC cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg18850127 chr7:39170497 POU6F2 -0.37 -5.2 -0.3 4.03e-7 IgG glycosylation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.2.195648145F chr2:195939902 NA 0.58 7.8 0.43 1.38e-13 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3857067 0.806 rs6857967 chr4:95112303 C/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.89e-17 QT interval; CESC cis rs7224314 1.000 rs8070689 chr17:65387405 G/T cg01507342 chr17:65387096 PITPNC1 -0.48 -5.67 -0.33 3.82e-8 Diisocyanate-induced asthma; CESC cis rs3782089 1.000 rs11605810 chr11:65300619 A/G cg00206168 chr11:65308501 LTBP3 0.95 6.33 0.36 1.07e-9 Height; CESC cis rs899997 0.862 rs8043123 chr15:78973393 C/T cg04896959 chr15:78267971 NA -0.41 -5.73 -0.33 2.7e-8 Coronary artery disease or large artery stroke; CESC cis rs11608355 0.545 rs4766603 chr12:109892106 T/C cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs6963495 0.818 rs56177071 chr7:105165648 C/T cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 6.85 0.39 5.3e-11 Bipolar disorder; CESC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg04756594 chr16:24857601 SLC5A11 -0.45 -5.52 -0.32 8.21e-8 Intelligence (multi-trait analysis); CESC cis rs116095464 0.558 rs2288457 chr5:231270 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.5 -0.46 1.44e-15 Breast cancer; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg22548015 chr20:30539544 PDRG1 -0.47 -6.07 -0.35 4.31e-9 Gut microbiota (bacterial taxa); CESC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.76 0.33 2.3e-8 Menopause (age at onset); CESC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg07677032 chr17:61819896 STRADA 0.44 5.89 0.34 1.15e-8 Prudent dietary pattern; CESC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg18230493 chr5:56204884 C5orf35 0.61 8.11 0.45 1.9e-14 Initial pursuit acceleration; CESC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg08470875 chr2:26401718 FAM59B -0.49 -5.38 -0.31 1.65e-7 Gut microbiome composition (summer); CESC cis rs12135062 1.000 rs12135062 chr1:3103312 A/C cg21609526 chr1:3105151 PRDM16 0.39 5.49 0.32 9.46e-8 Migraine; CESC cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.51 6.71 0.38 1.18e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs72634258 0.554 rs34020118 chr1:7895015 C/T cg26816564 chr1:7831052 VAMP3 0.61 5.31 0.31 2.35e-7 Inflammatory bowel disease; CESC cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg08508325 chr11:3079039 CARS -0.56 -10.58 -0.55 4.58e-22 Longevity; CESC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg07677032 chr17:61819896 STRADA 0.44 5.76 0.33 2.34e-8 Prudent dietary pattern; CESC cis rs2820315 0.505 rs10800792 chr1:201811144 G/A cg11586189 chr1:201857591 SHISA4 0.33 5.54 0.32 7.12e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; CESC cis rs1707322 0.717 rs3014246 chr1:46086077 C/T cg03146154 chr1:46216737 IPP -0.78 -10.75 -0.55 1.33e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01860753 chr1:206730586 RASSF5 -0.5 -6.44 -0.37 5.59e-10 Fibrinogen levels; CESC cis rs7914558 0.966 rs11191471 chr10:104702050 T/A cg04362960 chr10:104952993 NT5C2 0.42 5.38 0.31 1.63e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs34779708 0.733 rs16935945 chr10:35540320 A/C cg03585969 chr10:35415529 CREM 0.56 6.42 0.37 6.15e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs4654899 0.931 rs6661116 chr1:21337155 C/G cg05370193 chr1:21551575 ECE1 0.41 6.25 0.36 1.63e-9 Superior frontal gyrus grey matter volume; CESC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg18876405 chr7:65276391 NA -0.49 -6.83 -0.39 5.72e-11 Aortic root size; CESC cis rs950776 0.616 rs3743077 chr15:78894896 C/T cg06917634 chr15:78832804 PSMA4 0.62 8.14 0.45 1.52e-14 Sudden cardiac arrest; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01834151 chr15:52971181 KIAA1370 -0.56 -6.03 -0.35 5.43e-9 Gut microbiome composition (summer); CESC cis rs1670533 0.932 rs13106586 chr4:1054182 G/A cg27284194 chr4:1044797 NA 0.46 5.8 0.34 1.84e-8 Recombination rate (females); CESC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg04369109 chr6:150039330 LATS1 -0.43 -6.19 -0.36 2.31e-9 Lung cancer; CESC cis rs2932538 0.922 rs6658555 chr1:113098534 C/T cg22162597 chr1:113214053 CAPZA1 0.61 7.36 0.41 2.27e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs12765878 1.000 rs61277100 chr10:105643352 A/G cg11005552 chr10:105648138 OBFC1 0.35 5.1 0.3 6.34e-7 Coronary artery disease; CESC cis rs3733585 0.762 rs6449217 chr4:10009151 T/A cg00071950 chr4:10020882 SLC2A9 0.8 13.04 0.63 2.25e-30 Cleft plate (environmental tobacco smoke interaction); CESC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg01416388 chr22:39784598 NA -0.61 -7.47 -0.42 1.14e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1341267 0.529 rs6492720 chr13:95256305 T/C cg18412871 chr13:95254051 GPR180 -0.52 -6.87 -0.39 4.55e-11 Triglyceride levels; CESC cis rs832540 0.593 rs96844 chr5:56196604 G/A cg14703610 chr5:56206110 C5orf35 0.46 5.81 0.34 1.81e-8 Coronary artery disease; CESC cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg24920358 chr1:40204285 PPIE 0.43 6.4 0.37 7.07e-10 Blood protein levels; CESC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg17376030 chr22:41985996 PMM1 0.66 7.24 0.41 5.01e-12 Vitiligo; CESC cis rs2204008 0.774 rs2387811 chr12:38369794 C/A cg13010199 chr12:38710504 ALG10B 0.53 6.61 0.38 2.14e-10 Bladder cancer; CESC cis rs712039 0.652 rs8069062 chr17:35829306 C/T cg16670864 chr17:35848621 DUSP14 0.44 5.34 0.31 1.97e-7 Tuberculosis; CESC cis rs3768617 0.782 rs10911211 chr1:183022299 A/T ch.1.3577855R chr1:183094577 LAMC1 0.65 8.84 0.48 1.33e-16 Fuchs's corneal dystrophy; CESC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg00166722 chr3:10149974 C3orf24 0.44 5.65 0.33 4.11e-8 Alzheimer's disease; CESC cis rs1461503 0.966 rs4936764 chr11:122844492 G/A cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs6546537 0.955 rs1396798 chr2:69887837 G/T cg10773587 chr2:69614142 GFPT1 -0.45 -5.38 -0.31 1.66e-7 Serum thyroid-stimulating hormone levels; CESC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg05863683 chr7:1912471 MAD1L1 0.39 5.7 0.33 3.27e-8 Bipolar disorder and schizophrenia; CESC cis rs7582720 1.000 rs72934767 chr2:203766563 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6866344 0.697 rs72812613 chr5:178135257 G/A cg03877680 chr5:178157825 ZNF354A 0.78 8.94 0.48 6.74e-17 Neutrophil percentage of white cells; CESC trans rs78049276 0.736 rs6841473 chr4:148407652 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.63 -6.74 -0.38 1.01e-10 Pulse pressure; CESC cis rs4722166 0.597 rs2069845 chr7:22770149 G/A cg13104385 chr7:22767384 IL6 0.35 5.32 0.31 2.16e-7 Lung cancer; CESC cis rs7103648 0.966 rs874896 chr11:47418953 C/G cg20307385 chr11:47447363 PSMC3 0.94 16.43 0.71 2.71e-42 Diastolic blood pressure;Systolic blood pressure; CESC cis rs2295499 0.754 rs3864117 chr4:2626569 G/A cg08330972 chr4:2403930 ZFYVE28 -0.34 -5.54 -0.32 7.38e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs7144011 0.654 rs4903847 chr14:79854832 A/G cg12233833 chr10:830825 NA -0.48 -6.1 -0.35 3.78e-9 Waist circumference;Hip circumference; CESC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg01763666 chr17:80159506 CCDC57 -0.37 -5.26 -0.31 2.93e-7 Life satisfaction; CESC cis rs62344088 0.590 rs6882234 chr5:177389 C/G cg22857025 chr5:266934 NA -1.1 -8.56 -0.47 9.31e-16 Asthma (childhood onset); CESC cis rs17376456 0.825 rs10061377 chr5:93174513 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.08 0.3 7.11e-7 Diabetic retinopathy; CESC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11098499 0.604 rs2389887 chr4:120570644 T/C cg25214090 chr10:38739885 LOC399744 0.6 7.88 0.44 8.29e-14 Corneal astigmatism; CESC cis rs8141529 0.748 rs7287918 chr22:29281710 G/A cg15103426 chr22:29168792 CCDC117 0.61 7.81 0.43 1.31e-13 Lymphocyte counts; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg22648015 chr20:57485794 GNAS -0.44 -6.12 -0.35 3.32e-9 Systemic lupus erythematosus; CESC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg18016565 chr1:150552671 MCL1 -0.33 -5.07 -0.3 7.47e-7 Tonsillectomy; CESC trans rs1814175 0.817 rs7946556 chr11:49944874 G/A cg03929089 chr4:120376271 NA -0.93 -15.62 -0.69 1.95e-39 Height; CESC cis rs3749237 0.595 rs1568661 chr3:49520958 A/G cg03060546 chr3:49711283 APEH 0.76 11.23 0.57 3.32e-24 Resting heart rate; CESC cis rs10492096 0.945 rs2041386 chr12:6562538 C/T cg13857086 chr12:6580257 VAMP1 0.63 5.98 0.34 7.09e-9 Hip geometry; CESC cis rs11828289 0.660 rs17306384 chr11:23189320 T/C cg20040320 chr11:23191996 NA -0.68 -5.87 -0.34 1.31e-8 Cancer; CESC cis rs7845219 0.525 rs6471501 chr8:95922491 A/G cg13393036 chr8:95962371 TP53INP1 -0.44 -8.18 -0.45 1.17e-14 Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23575115 chr20:49348591 PARD6B -0.43 -6.51 -0.37 3.81e-10 Gambling; CESC cis rs7219021 1.000 rs4553671 chr17:46848272 T/C cg16584676 chr17:46985605 UBE2Z -0.7 -7.72 -0.43 2.37e-13 Schizophrenia or bipolar disorder; CESC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg26338869 chr17:61819248 STRADA 0.7 9.32 0.5 4.6e-18 Prudent dietary pattern; CESC cis rs17376456 0.825 rs12188163 chr5:93250608 A/G cg25358565 chr5:93447407 FAM172A -1.1 -10.4 -0.54 1.75e-21 Diabetic retinopathy; CESC cis rs2415984 0.562 rs1389604 chr14:46972218 C/A cg14871534 chr14:47121158 RPL10L 0.4 5.59 0.32 5.71e-8 Number of children ever born; CESC cis rs9473147 0.571 rs9463335 chr6:47479136 G/A cg20196966 chr6:47445060 CD2AP 0.43 5.48 0.32 9.88e-8 Platelet distribution width;Mean platelet volume; CESC cis rs17401966 0.838 rs912963 chr1:10348042 C/T cg15208524 chr1:10270712 KIF1B 0.4 5.16 0.3 4.94e-7 Hepatocellular carcinoma; CESC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.69 -0.38 1.29e-10 Electroencephalogram traits; CESC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg02951883 chr7:2050386 MAD1L1 -0.54 -7.24 -0.41 4.9e-12 Bipolar disorder and schizophrenia; CESC cis rs3126085 0.935 rs4845733 chr1:152162568 T/C cg26876637 chr1:152193138 HRNR 0.45 5.12 0.3 5.84e-7 Atopic dermatitis; CESC cis rs6893300 0.961 rs11739042 chr5:179182495 G/A cg14593053 chr5:179126677 CANX -0.52 -5.74 -0.33 2.58e-8 Resting heart rate; CESC cis rs4975616 0.804 rs462608 chr5:1336626 T/A cg06550200 chr5:1325588 CLPTM1L -0.65 -9.84 -0.52 1.16e-19 Lung cancer; CESC cis rs6540559 0.543 rs672819 chr1:210436404 T/A cg22029157 chr1:209979665 IRF6 0.52 5.89 0.34 1.17e-8 Cleft lip with or without cleft palate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11397493 chr1:3307215 PRDM16 0.38 6.06 0.35 4.71e-9 Fibrinogen levels; CESC cis rs66486766 1 rs66486766 chr15:84806060 G/A cg17507749 chr15:85114479 UBE2QP1 0.61 6.8 0.39 6.94e-11 Bipolar disorder lithium response (categorical) or schizophrenia; CESC cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg05283184 chr6:79620031 NA -0.44 -6.86 -0.39 4.89e-11 Intelligence (multi-trait analysis); CESC cis rs16854884 0.657 rs6769910 chr3:143737830 C/G cg06585982 chr3:143692056 C3orf58 0.5 6.7 0.38 1.26e-10 Economic and political preferences (feminism/equality); CESC cis rs9660992 1.000 rs1779410 chr1:205248759 A/G cg21643547 chr1:205240462 TMCC2 -0.44 -7.07 -0.4 1.38e-11 Mean corpuscular volume;Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06551418 chr8:145111391 OPLAH -0.53 -6.38 -0.36 7.72e-10 Gut microbiome composition (summer); CESC cis rs8005677 0.798 rs4982711 chr14:23398990 T/G cg01529538 chr14:23388837 RBM23 0.43 5.76 0.33 2.3e-8 Cognitive ability (multi-trait analysis); CESC cis rs847577 0.588 rs12666406 chr7:97790991 G/A cg24562669 chr7:97807699 LMTK2 0.83 13.66 0.64 1.64e-32 Breast cancer; CESC cis rs11030122 0.632 rs10835556 chr11:4083013 A/G cg18678763 chr11:4115507 RRM1 -0.52 -6.97 -0.39 2.59e-11 Mean platelet volume;Platelet distribution width; CESC cis rs2180341 0.960 rs6900074 chr6:127685893 A/G cg27446573 chr6:127587934 RNF146 1.05 15.58 0.69 2.65e-39 Breast cancer; CESC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.16 -0.3 4.76e-7 Developmental language disorder (linguistic errors); CESC cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg20908204 chr19:46285434 DMPK -0.35 -5.1 -0.3 6.47e-7 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09039436 chr11:46369515 DGKZ -0.45 -6.02 -0.35 5.86e-9 Fibrinogen levels; CESC cis rs6088580 0.609 rs6058029 chr20:32969643 T/C cg24642439 chr20:33292090 TP53INP2 -0.52 -6.9 -0.39 3.82e-11 Glomerular filtration rate (creatinine); CESC cis rs12541635 0.639 rs6415444 chr8:107043797 G/A cg10147462 chr8:107024639 NA 0.43 6.31 0.36 1.16e-9 Age of smoking initiation; CESC cis rs34779708 0.733 rs4391768 chr10:35547595 A/G cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs9303401 0.659 rs9303399 chr17:56672309 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.06 13.0 0.62 3.28e-30 Cognitive test performance; CESC cis rs4704187 0.687 rs6866661 chr5:74534372 A/G cg03227963 chr5:74354835 NA 0.27 5.04 0.3 8.67e-7 Response to amphetamines; CESC cis rs9522267 0.737 rs12429582 chr13:112226657 A/G cg10483660 chr13:112241077 NA -0.31 -5.19 -0.3 4.26e-7 Hepatitis; CESC cis rs919433 0.926 rs787997 chr2:198216271 A/G cg10820045 chr2:198174542 NA 0.39 5.88 0.34 1.21e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg26314531 chr2:26401878 FAM59B -0.62 -6.99 -0.39 2.29e-11 Gut microbiome composition (summer); CESC trans rs66573146 0.656 rs56094305 chr4:6956086 C/T cg07817883 chr1:32538562 TMEM39B 1.25 8.67 0.47 4.33e-16 Granulocyte percentage of myeloid white cells; CESC cis rs13064411 0.735 rs13098166 chr3:113210038 A/G cg18753928 chr3:113234510 CCDC52 -0.52 -6.31 -0.36 1.17e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg11952622 chr19:58962976 ZNF324B 0.46 6.13 0.35 3.11e-9 Uric acid clearance; CESC cis rs2228479 0.702 rs78331410 chr16:89917775 C/T cg06558623 chr16:89946397 TCF25 1.15 8.39 0.46 2.95e-15 Skin colour saturation; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10519680 chr8:37707506 BRF2 0.47 6.14 0.35 3.04e-9 Systemic lupus erythematosus; CESC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg21770322 chr7:97807741 LMTK2 0.54 8.15 0.45 1.45e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg18876405 chr7:65276391 NA 0.54 7.06 0.4 1.5e-11 Aortic root size; CESC trans rs11088226 1.000 rs2833889 chr21:33927768 G/T cg09050820 chr6:167586206 TCP10L2 -0.58 -6.06 -0.35 4.63e-9 Gastritis; CESC trans rs3749237 1.000 rs11717256 chr3:49868520 C/T cg21659725 chr3:3221576 CRBN 0.53 6.38 0.36 8.01e-10 Resting heart rate; CESC cis rs9399137 0.507 rs4895437 chr6:135317354 G/A cg24558204 chr6:135376177 HBS1L 0.72 10.08 0.53 1.92e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs2072732 0.861 rs72856440 chr1:2956582 A/G cg03976712 chr1:2946727 NA 0.33 5.52 0.32 8.2e-8 Plateletcrit; CESC cis rs9814567 1.000 rs7371896 chr3:134249769 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.92 -0.34 9.73e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg06505273 chr16:24850292 NA 0.48 5.46 0.32 1.11e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1023500 0.505 rs134886 chr22:42673856 C/T cg15557168 chr22:42548783 NA 0.46 7.26 0.41 4.39e-12 Schizophrenia; CESC cis rs10208940 0.920 rs13422657 chr2:68706989 T/C cg12452813 chr2:68675892 NA 0.52 5.24 0.31 3.26e-7 Urate levels in lean individuals; CESC cis rs1065852 0.526 rs4822079 chr22:42394612 G/C cg22189786 chr22:42395067 WBP2NL 0.44 5.46 0.32 1.08e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06033368 chr22:38597807 MAFF 0.57 6.06 0.35 4.73e-9 Gut microbiome composition (summer); CESC cis rs7927771 0.524 rs10838774 chr11:47856114 A/G cg18512352 chr11:47633146 NA 0.35 5.43 0.32 1.24e-7 Subjective well-being; CESC cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg08704250 chr15:31115839 NA 0.65 7.21 0.41 5.81e-12 Huntington's disease progression; CESC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg15664640 chr17:80829946 TBCD -0.6 -8.58 -0.47 8e-16 Breast cancer; CESC cis rs2108622 0.727 rs12609900 chr19:15982414 G/A cg13772218 chr19:15982569 NA 0.29 5.8 0.34 1.85e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs75477785 0.590 rs4844502 chr1:210104743 A/T cg02304930 chr1:210405566 SERTAD4;C1orf133 -0.87 -6.68 -0.38 1.42e-10 Cleft lip with or without cleft palate; CESC cis rs8114671 0.836 rs2425012 chr20:33581955 G/A cg06115741 chr20:33292138 TP53INP2 -0.44 -5.22 -0.31 3.55e-7 Height; CESC trans rs453301 0.571 rs330057 chr8:9089793 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -6.52 -0.37 3.52e-10 Joint mobility (Beighton score); CESC cis rs9303401 0.704 rs7359501 chr17:56641200 C/T cg12560992 chr17:57184187 TRIM37 0.56 7.18 0.4 6.88e-12 Cognitive test performance; CESC cis rs55986470 0.763 rs10188853 chr2:239430558 G/C cg18131467 chr2:239335373 ASB1 -0.52 -5.75 -0.33 2.39e-8 Chronotype; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg21951975 chr1:209979733 IRF6 0.75 16.51 0.71 1.35e-42 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs10479542 0.929 rs10078796 chr5:178978883 T/A cg26516362 chr5:178986906 RUFY1 0.45 7.08 0.4 1.28e-11 Lung cancer; CESC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.48 -0.32 9.89e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg07701084 chr6:150067640 NUP43 0.52 7.22 0.41 5.55e-12 Lung cancer; CESC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg04369109 chr6:150039330 LATS1 -0.4 -5.61 -0.33 4.98e-8 Lung cancer; CESC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 10.85 0.55 6.37e-23 Platelet count; CESC cis rs10089 1.000 rs10478798 chr5:127442394 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.77 10.58 0.55 4.65e-22 Ileal carcinoids; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04835431 chr14:105684005 BRF1 -0.53 -6.03 -0.35 5.59e-9 Gut microbiome composition (summer); CESC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg07648498 chr16:89883185 FANCA 0.43 5.37 0.31 1.71e-7 Vitiligo; CESC cis rs10851478 0.872 rs12908624 chr15:49797933 G/A cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs4481887 0.927 rs10788779 chr1:248481661 C/G cg00666640 chr1:248458726 OR2T12 0.34 5.76 0.33 2.35e-8 Common traits (Other); CESC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg12927641 chr6:109611667 NA -0.37 -5.57 -0.32 6.2e-8 Reticulocyte fraction of red cells; CESC cis rs7301826 0.651 rs10848210 chr12:131312020 G/A cg11011512 chr12:131303247 STX2 0.46 5.75 0.33 2.48e-8 Plasma plasminogen activator levels; CESC cis rs7937682 0.681 rs2156580 chr11:111394328 C/G cg09085632 chr11:111637200 PPP2R1B 0.49 5.7 0.33 3.25e-8 Primary sclerosing cholangitis; CESC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg24531977 chr5:56204891 C5orf35 -0.87 -10.87 -0.56 5.43e-23 Initial pursuit acceleration; CESC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg04267008 chr7:1944627 MAD1L1 -0.47 -5.58 -0.32 5.95e-8 Schizophrenia; CESC cis rs6681460 0.800 rs539014 chr1:67211887 C/T cg02459107 chr1:67143332 SGIP1 -0.34 -5.07 -0.3 7.5e-7 Presence of antiphospholipid antibodies; CESC cis rs67311347 1.000 rs6762251 chr3:40531136 A/G cg09455208 chr3:40491958 NA -0.44 -7.31 -0.41 3.12e-12 Renal cell carcinoma; CESC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg11890956 chr21:40555474 PSMG1 1.17 21.82 0.8 4.14e-61 Cognitive function; CESC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg21747405 chr11:67723411 NA -0.44 -6.69 -0.38 1.3100000000000001e-10 Blood pressure (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15993083 chr12:4381788 CCND2 -0.48 -6.34 -0.36 1e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03813443 chr1:232765924 NA 0.58 6.26 0.36 1.55e-9 Gut microbiome composition (summer); CESC cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg05343316 chr1:45956843 TESK2 -0.51 -6.75 -0.38 9.49e-11 High light scatter reticulocyte count; CESC cis rs67460515 0.859 rs7610800 chr3:161002582 C/T cg03342759 chr3:160939853 NMD3 -0.52 -7.44 -0.42 1.45e-12 Parkinson's disease; CESC cis rs12200560 0.505 rs211173 chr6:97070804 C/T cg06623918 chr6:96969491 KIAA0776 0.46 5.75 0.33 2.48e-8 Coronary heart disease; CESC cis rs910316 1.000 rs10143132 chr14:75525850 G/A cg11812906 chr14:75593930 NEK9 0.89 14.86 0.67 9.77e-37 Height; CESC cis rs4664308 0.870 rs55959207 chr2:161016981 A/C cg03641300 chr2:160917029 PLA2R1 -0.62 -9.13 -0.49 1.82e-17 Idiopathic membranous nephropathy; CESC cis rs10883723 0.810 rs2296589 chr10:104248106 T/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.93e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs909341 0.710 rs6011016 chr20:62302650 C/G cg03999872 chr20:62272968 STMN3 0.56 5.47 0.32 1.06e-7 Atopic dermatitis; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg00760200 chr1:115053833 TRIM33 -0.42 -6.01 -0.35 6.1e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11317343 chr5:177580912 NHP2 0.45 6.08 0.35 4.14e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg02725872 chr8:58115012 NA -0.44 -6.89 -0.39 3.94e-11 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg25036284 chr2:26402008 FAM59B 0.76 8.46 0.46 1.79e-15 Gut microbiome composition (summer); CESC cis rs6032067 0.777 rs62208385 chr20:43789823 A/T cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg18402987 chr7:1209562 NA 0.75 8.6 0.47 7.26e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02442412 chr4:83720054 SCD5 0.46 6.68 0.38 1.38e-10 Gut microbiota (bacterial taxa); CESC cis rs3857536 0.740 rs9354392 chr6:66894555 G/T cg07460842 chr6:66804631 NA -0.43 -5.54 -0.32 7.31e-8 Blood trace element (Cu levels); CESC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.6 0.33 5.44e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg18446336 chr7:2847575 GNA12 -0.36 -5.54 -0.32 7.32e-8 Height; CESC cis rs863345 0.967 rs7526514 chr1:158532405 T/G cg12129480 chr1:158549410 OR10X1 -0.33 -6.66 -0.38 1.58e-10 Pneumococcal bacteremia; CESC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg17971929 chr21:40555470 PSMG1 -0.87 -12.84 -0.62 1.11e-29 Cognitive function; CESC cis rs897080 0.552 rs1067378 chr2:44648047 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.56 0.32 6.51e-8 Height; CESC trans rs208520 0.955 rs208538 chr6:66964492 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.78 -8.63 -0.47 5.64e-16 Exhaled nitric oxide output; CESC cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg03433033 chr1:76189801 ACADM 0.54 6.25 0.36 1.65e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg11247378 chr22:39784982 NA -0.63 -9.52 -0.5 1.14e-18 Intelligence (multi-trait analysis); CESC cis rs7474896 0.515 rs2738203 chr10:38277596 G/A cg25427524 chr10:38739819 LOC399744 0.52 5.58 0.32 5.94e-8 Obesity (extreme); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg07970400 chr15:40650285 DISP2 -0.45 -6.04 -0.35 5.2e-9 Recombination measurement; CESC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg00129232 chr17:37814104 STARD3 -0.57 -7.57 -0.42 6.31e-13 Glomerular filtration rate (creatinine); CESC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg14393609 chr7:65229607 NA -0.47 -6.31 -0.36 1.14e-9 Aortic root size; CESC cis rs4891159 1.000 rs4891159 chr18:74101941 A/G cg24786174 chr18:74118243 ZNF516 0.58 8.53 0.46 1.14e-15 Longevity; CESC cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg04455712 chr21:45112962 RRP1B 0.38 5.58 0.32 6.09e-8 Mean corpuscular volume; CESC cis rs7703051 0.901 rs4704223 chr5:74773420 T/C cg03227963 chr5:74354835 NA 0.29 5.35 0.31 1.92e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg03605463 chr16:89740564 NA 0.64 7.48 0.42 1.08e-12 Vitiligo; CESC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08822737 chr17:71088851 SLC39A11 -0.49 -6.52 -0.37 3.49e-10 Fibrinogen levels; CESC cis rs7605827 0.930 rs7605730 chr2:15598696 A/G cg19274914 chr2:15703543 NA 0.32 5.67 0.33 3.71e-8 Educational attainment (years of education); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17286491 chr1:179923514 CEP350 0.47 6.17 0.35 2.57e-9 Systemic lupus erythematosus; CESC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs35520189 0.591 rs12618418 chr2:113707645 G/T cg06156847 chr2:113672199 IL1F7 0.37 5.31 0.31 2.3e-7 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs1348850 0.526 rs10930797 chr2:178437553 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 5.05 0.3 8.17e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs13242816 1.000 rs35595472 chr7:116122306 G/A cg04696780 chr7:116139425 CAV2 -0.59 -5.23 -0.31 3.42e-7 P wave duration; CESC cis rs35110281 0.743 rs2329443 chr21:45059431 C/T cg01579765 chr21:45077557 HSF2BP -0.57 -9.28 -0.5 6.43e-18 Mean corpuscular volume; CESC cis rs9487051 0.714 rs9487053 chr6:109619697 T/C cg21918786 chr6:109611834 NA -0.36 -5.28 -0.31 2.64e-7 Reticulocyte fraction of red cells; CESC cis rs921968 0.678 rs500422 chr2:219432995 C/A cg02176678 chr2:219576539 TTLL4 0.39 6.68 0.38 1.44e-10 Mean corpuscular hemoglobin concentration; CESC cis rs12478296 1.000 rs73007138 chr2:243007041 C/T cg06360820 chr2:242988706 NA -1.01 -10.1 -0.53 1.72e-20 Obesity-related traits; CESC cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg12292205 chr6:26970375 C6orf41 -0.55 -5.81 -0.34 1.74e-8 Intelligence (multi-trait analysis); CESC cis rs7662987 0.517 rs1453874 chr4:100022724 G/A cg12011299 chr4:100065546 ADH4 0.6 6.6 0.38 2.23e-10 Smoking initiation; CESC trans rs3780486 0.505 rs10758188 chr9:33123386 C/T cg04842962 chr6:43655489 MRPS18A -0.73 -11.43 -0.57 7.37e-25 IgG glycosylation; CESC cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7084402 0.967 rs1649035 chr10:60332701 A/T cg07615347 chr10:60278583 BICC1 0.57 8.91 0.48 8.63e-17 Refractive error; CESC cis rs3747547 1.000 rs72724190 chr9:37942005 A/G cg13774184 chr9:37916125 SHB -0.75 -6.32 -0.36 1.12e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs763014 0.966 rs4144003 chr16:645968 C/T cg00802000 chr16:706648 WDR90 -0.4 -6.07 -0.35 4.32e-9 Height; CESC cis rs8114671 0.562 rs6087641 chr20:33467717 T/C cg24642439 chr20:33292090 TP53INP2 0.41 5.05 0.3 8.09e-7 Height; CESC cis rs2749592 1.000 rs2749592 chr10:38258842 A/C cg25427524 chr10:38739819 LOC399744 -0.46 -5.83 -0.34 1.61e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs17826219 0.500 rs2449749 chr17:29078298 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Body mass index; CESC cis rs6546550 0.901 rs6546556 chr2:70139001 A/G cg02498382 chr2:70120550 SNRNP27 -0.41 -7.26 -0.41 4.34e-12 Prevalent atrial fibrillation; CESC cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg06212747 chr3:49208901 KLHDC8B 0.76 10.35 0.54 2.7e-21 Parkinson's disease; CESC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg06420487 chr17:61919686 SMARCD2 0.44 5.3 0.31 2.43e-7 Height; CESC cis rs8067545 0.750 rs4005937 chr17:19959828 A/C cg13482628 chr17:19912719 NA 0.37 5.06 0.3 7.79e-7 Schizophrenia; CESC cis rs6547741 0.935 rs2384626 chr2:27773648 A/G cg21248554 chr2:27665150 KRTCAP3 0.26 5.41 0.32 1.4e-7 Oral cavity cancer; CESC cis rs6732160 0.613 rs57208378 chr2:73389999 G/A cg01422370 chr2:73384389 NA 0.55 8.67 0.47 4.33e-16 Intelligence (multi-trait analysis); CESC cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg24110177 chr3:50126178 RBM5 0.52 7.18 0.4 6.85e-12 Intelligence (multi-trait analysis); CESC cis rs7296418 0.885 rs1051434 chr12:123641200 C/T cg05973401 chr12:123451056 ABCB9 0.53 6.78 0.38 8.01e-11 Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25109393 chr5:73936428 ENC1 -0.52 -7.17 -0.4 7.47e-12 Fibrinogen levels; CESC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg22903471 chr2:27725779 GCKR -0.54 -7.39 -0.41 1.93e-12 Total body bone mineral density; CESC cis rs425277 1.000 rs196128 chr1:2078444 T/G cg24578937 chr1:2090814 PRKCZ 0.55 9.54 0.51 9.57e-19 Height; CESC cis rs6842047 1.000 rs1877320 chr4:187131279 G/A cg02012338 chr4:187126139 CYP4V2 0.74 5.96 0.34 7.84e-9 Blood protein levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12064626 chr21:40817896 SH3BGR -0.46 -6.39 -0.37 7.38e-10 Gut microbiota (bacterial taxa); CESC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg00129232 chr17:37814104 STARD3 0.57 7.58 0.42 5.64e-13 Glomerular filtration rate (creatinine); CESC cis rs11264213 0.786 rs72659673 chr1:36242004 G/A cg27506609 chr1:36549197 TEKT2 0.65 5.34 0.31 1.97e-7 Schizophrenia; CESC cis rs7586879 1.000 rs6736711 chr2:25116456 C/T cg01884057 chr2:25150051 NA 0.28 5.12 0.3 5.86e-7 Body mass index; CESC cis rs947211 1.000 rs947211 chr1:205752665 A/G cg26354017 chr1:205819088 PM20D1 0.41 5.18 0.3 4.42e-7 Parkinson's disease; CESC cis rs9300255 0.722 rs28458312 chr12:123863265 G/T cg19016782 chr12:123741754 C12orf65 0.46 6.33 0.36 1.04e-9 Neutrophil percentage of white cells; CESC cis rs6815814 0.731 rs28532329 chr4:38771368 C/T cg02016764 chr4:38805732 TLR1 -0.44 -6.08 -0.35 4.24e-9 Breast cancer; CESC cis rs12048904 0.964 rs3188491 chr1:101338482 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.54 7.04 0.4 1.62e-11 Multiple sclerosis; CESC cis rs2290159 0.948 rs11711270 chr3:12639596 C/T cg23032965 chr3:12705835 RAF1 0.49 5.45 0.32 1.14e-7 Cholesterol, total; CESC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.53 0.37 3.24e-10 Bipolar disorder; CESC trans rs1814175 0.646 rs1722010 chr11:49897958 A/G cg15704280 chr7:45808275 SEPT13 -1.0 -18.78 -0.76 1.35e-50 Height; CESC trans rs6414928 0.516 rs34286815 chr5:25935440 C/T cg17053223 chr7:94535617 PPP1R9A -0.56 -6.17 -0.35 2.49e-9 Facial morphology (factor 5, width of mouth relative to central midface); CESC cis rs863345 0.604 rs1873511 chr1:158461366 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -7.17 -0.4 7.58e-12 Pneumococcal bacteremia; CESC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg18225595 chr11:63971243 STIP1 0.72 9.62 0.51 5.43e-19 Platelet count; CESC cis rs711245 0.574 rs1179494 chr2:36809496 C/G cg09467607 chr2:36825704 FEZ2 -0.55 -10.16 -0.53 1.04e-20 Height; CESC cis rs3764400 0.506 rs72827851 chr17:46452495 C/A cg10706073 chr17:46328419 SKAP1 -0.66 -5.15 -0.3 5.03e-7 Body mass index; CESC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg08859206 chr1:53392774 SCP2 -0.59 -7.77 -0.43 1.69e-13 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01204535 chr5:162888518 NUDCD2;HMMR -0.56 -6.57 -0.37 2.6e-10 Gut microbiome composition (summer); CESC cis rs644799 0.965 rs1944080 chr11:95503636 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.94 0.39 3.05e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7824557 0.778 rs6601572 chr8:11093337 C/G cg21775007 chr8:11205619 TDH -0.35 -5.27 -0.31 2.89e-7 Retinal vascular caliber; CESC cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg11742103 chr11:62369870 EML3;MTA2 0.67 10.4 0.54 1.88e-21 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs922182 0.547 rs12907026 chr15:64271604 A/C cg24729988 chr15:64271149 DAPK2 -0.61 -9.06 -0.49 2.93e-17 Blood protein levels; CESC cis rs66573146 0.572 rs67252699 chr4:6946411 A/G cg26116260 chr4:7069785 GRPEL1 -0.8 -5.23 -0.31 3.39e-7 Granulocyte percentage of myeloid white cells; CESC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg13206674 chr6:150067644 NUP43 0.49 7.03 0.4 1.79e-11 Lung cancer; CESC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.89 0.34 1.15e-8 Tonsillectomy; CESC cis rs11997175 0.550 rs7464954 chr8:33832202 A/G ch.8.33884649F chr8:33765107 NA 0.6 7.45 0.42 1.35e-12 Body mass index; CESC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg04944784 chr2:26401820 FAM59B 0.85 9.15 0.49 1.61e-17 Gut microbiome composition (summer); CESC trans rs7937682 0.889 rs541198 chr11:111475340 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.11 0.35 3.49e-9 Primary sclerosing cholangitis; CESC cis rs7945705 0.902 rs10743093 chr11:8869129 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.47 7.44 0.42 1.36e-12 Hemoglobin concentration; CESC cis rs4689388 0.926 rs4689391 chr4:6280449 G/A cg00701064 chr4:6280414 WFS1 0.77 14.05 0.65 7.04e-34 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7095944 0.614 rs4962697 chr10:126447545 G/C cg08799069 chr10:126477246 METTL10 -0.37 -5.28 -0.31 2.7e-7 Asthma; CESC cis rs17384381 0.859 rs28529751 chr1:85910951 G/A cg16011679 chr1:85725395 C1orf52 0.68 6.92 0.39 3.45e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg07952391 chr2:88470173 THNSL2 -0.55 -8.35 -0.46 3.72e-15 Response to metformin (IC50); CESC cis rs2273669 0.588 rs6568555 chr6:109331777 A/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs7927771 0.507 rs12366244 chr11:47882130 C/A cg18512352 chr11:47633146 NA 0.35 5.43 0.32 1.29e-7 Subjective well-being; CESC cis rs6429082 0.818 rs291341 chr1:235663174 G/T cg26050004 chr1:235667680 B3GALNT2 0.67 8.42 0.46 2.43e-15 Adiposity; CESC cis rs17666538 0.585 rs6559064 chr8:623061 G/A cg02524346 chr8:600233 NA 0.84 5.97 0.34 7.53e-9 IgG glycosylation; CESC cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6570726 0.837 rs636894 chr6:145864122 T/C cg05347473 chr6:146136440 FBXO30 0.46 6.16 0.35 2.72e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs644799 1.000 rs7749 chr11:95565789 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.55 0.37 2.97e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg08948823 chr16:67881367 CENPT;NUTF2 -0.5 -6.07 -0.35 4.31e-9 Lung cancer in ever smokers; CESC cis rs6714710 0.603 rs4311104 chr2:98424802 A/G cg26665480 chr2:98280029 ACTR1B 0.56 7.96 0.44 5.02e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs3733585 0.699 rs57574512 chr4:9960182 T/C cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.78 9.64 0.51 4.81e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs7246865 0.510 rs2305756 chr19:17169936 C/T cg16202187 chr19:17186497 HAUS8;MYO9B 0.49 6.44 0.37 5.52e-10 Reticulocyte fraction of red cells; CESC cis rs9612 1.000 rs1059 chr19:44268348 C/T cg08581076 chr19:44259116 C19orf61 0.49 5.76 0.33 2.35e-8 Exhaled nitric oxide output; CESC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg07414643 chr4:187882934 NA -0.52 -7.38 -0.41 2.04e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs72781680 1.000 rs17763442 chr2:24255991 C/T cg20701182 chr2:24300061 SF3B14 0.99 8.48 0.46 1.64e-15 Lymphocyte counts; CESC cis rs4700695 0.719 rs27586 chr5:65445873 G/A cg21114390 chr5:65439923 SFRS12 -0.49 -6.04 -0.35 5.09e-9 Facial morphology (factor 19); CESC cis rs854765 0.583 rs66531105 chr17:17809001 C/T cg04398451 chr17:18023971 MYO15A -0.67 -9.59 -0.51 6.66e-19 Total body bone mineral density; CESC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg12379764 chr21:47803548 PCNT -0.46 -5.85 -0.34 1.46e-8 Testicular germ cell tumor; CESC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg03188948 chr7:1209495 NA 0.67 6.45 0.37 5.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.28 0.81 1.08e-62 Prudent dietary pattern; CESC cis rs7520050 1.000 rs7540699 chr1:46338585 A/G cg03146154 chr1:46216737 IPP -0.48 -6.22 -0.36 1.98e-9 Red blood cell count;Reticulocyte count; CESC cis rs9818941 0.826 rs2712321 chr3:157644344 C/T cg08654915 chr3:157813417 NA 0.49 7.86 0.43 9.52e-14 Height; CESC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg22920501 chr2:26401640 FAM59B -0.67 -8.12 -0.45 1.72e-14 Gut microbiome composition (summer); CESC cis rs1003719 0.680 rs7275984 chr21:38505696 C/A cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.47 -0.46 1.69e-15 Eye color traits; CESC cis rs79349575 0.783 rs4793995 chr17:47019399 A/C cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs3806843 1.000 rs1030165 chr5:140185448 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.33 -0.31 2.08e-7 Depressive symptoms (multi-trait analysis); CESC cis rs8077889 0.672 rs2106764 chr17:41852717 T/A cg26893861 chr17:41843967 DUSP3 1.0 18.44 0.75 2.03e-49 Triglycerides; CESC cis rs6575793 1.000 rs8006176 chr14:101033288 A/G cg18516195 chr14:101012996 BEGAIN 0.47 6.42 0.37 6.4e-10 Menarche (age at onset); CESC cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg23711669 chr6:146136114 FBXO30 1.01 15.66 0.69 1.45e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.95e-10 Life satisfaction; CESC cis rs2243480 1.000 rs34637256 chr7:65360131 G/A cg25894440 chr7:65020034 NA -0.59 -5.03 -0.3 9.19e-7 Diabetic kidney disease; CESC cis rs7647973 0.577 rs6446247 chr3:49102001 A/T cg06212747 chr3:49208901 KLHDC8B 0.49 5.51 0.32 8.6e-8 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22980722 chr21:45719818 PFKL 0.6 7.41 0.41 1.69e-12 Gut microbiome composition (summer); CESC trans rs8073060 0.586 rs4796100 chr17:33997657 G/T cg19694781 chr19:47549865 TMEM160 0.75 7.38 0.41 2.07e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs6582630 0.555 rs7978749 chr12:38527141 G/T cg13010199 chr12:38710504 ALG10B 0.46 5.95 0.34 8.41e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs17854409 0.881 rs12625401 chr20:61472939 A/T cg05147244 chr20:61493195 TCFL5 0.98 6.61 0.38 2.1e-10 Obesity-related traits; CESC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.42e-7 Lung cancer; CESC trans rs116095464 0.558 rs2288457 chr5:231270 C/T cg00938859 chr5:1591904 SDHAP3 0.63 6.87 0.39 4.48e-11 Breast cancer; CESC cis rs7659604 0.540 rs10020581 chr4:122676559 A/C cg19671926 chr4:122722719 EXOSC9 0.53 6.7 0.38 1.21e-10 Type 2 diabetes; CESC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg23161317 chr6:28129485 ZNF389 0.49 6.29 0.36 1.31e-9 Parkinson's disease; CESC cis rs9430161 0.644 rs6685766 chr1:11037051 T/C cg27631724 chr1:11040367 C1orf127 0.46 7.81 0.43 1.36e-13 Ewing sarcoma; CESC cis rs17401966 0.931 rs11585794 chr1:10443867 G/A cg15208524 chr1:10270712 KIF1B 0.41 5.23 0.31 3.51e-7 Hepatocellular carcinoma; CESC cis rs10189230 0.967 rs13026378 chr2:222352712 G/A cg14652038 chr2:222343519 EPHA4 0.37 7.76 0.43 1.85e-13 Urate levels in lean individuals; CESC cis rs7937682 0.855 rs10891285 chr11:111527775 T/C cg09085632 chr11:111637200 PPP2R1B -1.0 -16.54 -0.71 1.09e-42 Primary sclerosing cholangitis; CESC cis rs6582630 0.555 rs11182217 chr12:38480030 G/A cg26384229 chr12:38710491 ALG10B 0.67 10.0 0.52 3.5e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg19729930 chr2:74357872 NA 0.94 12.23 0.6 1.48e-27 Gestational age at birth (maternal effect); CESC cis rs2952156 0.920 rs8078228 chr17:37834998 C/T cg07936489 chr17:37558343 FBXL20 -0.6 -7.98 -0.44 4.35e-14 Asthma; CESC cis rs4835473 0.932 rs6537231 chr4:144907642 T/C cg25736465 chr4:144833511 NA 0.41 6.29 0.36 1.28e-9 Immature fraction of reticulocytes; CESC cis rs712039 0.652 rs11656503 chr17:35772021 G/T cg16670864 chr17:35848621 DUSP14 0.44 5.5 0.32 8.74e-8 Tuberculosis; CESC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg06873352 chr17:61820015 STRADA 0.72 12.77 0.62 2.07e-29 Prudent dietary pattern; CESC cis rs7044106 0.762 rs1158554 chr9:123400898 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.86 0.34 1.38e-8 Hip circumference adjusted for BMI; CESC cis rs6582630 0.537 rs12823925 chr12:38409323 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.57 0.54 4.96e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs2236918 0.643 rs1776139 chr1:242027363 T/G cg17736920 chr1:242011382 EXO1 0.5 6.39 0.37 7.43e-10 Menopause (age at onset); CESC trans rs17685 0.753 rs869804 chr7:75688954 A/G cg19862616 chr7:65841803 NCRNA00174 0.83 12.47 0.61 2.23e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs9359856 0.517 rs11962350 chr6:90592406 G/A cg13799429 chr6:90582589 CASP8AP2 -0.8 -7.56 -0.42 6.5e-13 Bipolar disorder; CESC cis rs11599315 1.000 rs11599315 chr10:1343017 C/T cg09624528 chr10:1369823 ADARB2 0.44 5.96 0.34 7.9e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs12545109 0.800 rs1996105 chr8:57413123 A/G cg09654669 chr8:57350985 NA -0.54 -6.35 -0.36 9.45e-10 Obesity-related traits; CESC cis rs858239 1.000 rs156407 chr7:23315639 G/A cg23682824 chr7:23144976 KLHL7 0.45 5.96 0.34 8.22e-9 Cerebrospinal fluid biomarker levels; CESC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -5.13 -0.3 5.63e-7 Developmental language disorder (linguistic errors); CESC cis rs17376456 0.825 rs10214278 chr5:93237679 C/T cg21475434 chr5:93447410 FAM172A -0.79 -6.62 -0.38 1.95e-10 Diabetic retinopathy; CESC cis rs757110 0.866 rs5213 chr11:17408404 C/T cg11839944 chr11:17409644 KCNJ11 0.41 5.57 0.32 6.12e-8 Type 2 diabetes; CESC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg05255149 chr17:80675120 FN3KRP 0.45 5.1 0.3 6.33e-7 Glycated hemoglobin levels; CESC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2652822 0.584 rs1017546 chr15:63566702 G/T cg02713581 chr15:63449717 RPS27L -0.46 -6.04 -0.35 5.29e-9 Metabolic traits; CESC cis rs34779708 0.966 rs2045915 chr10:35418616 G/C cg04310649 chr10:35416472 CREM -0.53 -6.32 -0.36 1.1e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs116095464 0.558 rs28558836 chr5:285748 C/G cg22496380 chr5:211416 CCDC127 -0.72 -8.29 -0.45 5.54e-15 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13411897 chr3:12526166 TSEN2 0.56 6.53 0.37 3.27e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg03676636 chr4:99064102 C4orf37 0.37 5.36 0.31 1.84e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg18758796 chr5:131593413 PDLIM4 0.4 5.5 0.32 9.08e-8 Breast cancer; CESC cis rs9837602 0.592 rs694429 chr3:99459669 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -5.94 -0.34 8.93e-9 Breast cancer; CESC trans rs757081 0.667 rs7108067 chr11:17200220 G/A cg00391031 chr10:72237473 KIAA1274 0.31 6.05 0.35 4.99e-9 Systolic blood pressure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14741666 chr17:34842576 ZNHIT3 0.56 7.15 0.4 8.23e-12 Gut microbiota (bacterial taxa); CESC cis rs1371867 0.846 rs1660323 chr8:101278724 T/A cg11906718 chr8:101322791 RNF19A 0.5 6.39 0.37 7.26e-10 Atrioventricular conduction; CESC cis rs909002 0.962 rs10798883 chr1:32140305 C/T cg13919466 chr1:32135498 COL16A1 -0.51 -9.54 -0.51 9.73e-19 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10972431 chr13:100258753 CLYBL 0.56 6.17 0.35 2.59e-9 Gut microbiome composition (summer); CESC cis rs6688613 0.694 rs11576455 chr1:166811970 G/A cg07049167 chr1:166818506 POGK 0.46 5.47 0.32 1.03e-7 Refractive astigmatism; CESC trans rs61931739 0.517 rs7958856 chr12:34294737 T/C cg26384229 chr12:38710491 ALG10B 0.62 8.67 0.47 4.48e-16 Morning vs. evening chronotype; CESC cis rs6500602 0.647 rs4785967 chr16:4523208 G/A cg08645402 chr16:4508243 NA 0.57 9.04 0.49 3.3e-17 Schizophrenia; CESC cis rs228437 1.000 rs228436 chr6:134896913 A/T cg24504307 chr6:134963096 NA 0.5 5.42 0.32 1.37e-7 Melanoma; CESC cis rs1784581 0.775 rs7755404 chr6:162427731 T/C cg17173639 chr6:162384350 PARK2 0.61 9.43 0.5 2.11e-18 Itch intensity from mosquito bite; CESC cis rs2370759 1.000 rs16933225 chr10:32599464 C/T cg18270830 chr10:32634957 EPC1 0.73 7.64 0.43 3.89e-13 Sexual dysfunction (female); CESC cis rs847577 0.630 rs3801294 chr7:97822210 G/A cg24562669 chr7:97807699 LMTK2 0.84 13.88 0.65 2.69e-33 Breast cancer; CESC cis rs10032549 0.535 rs4859445 chr4:77382068 T/C cg20311846 chr4:77356250 SHROOM3 -0.28 -5.32 -0.31 2.21e-7 Glomerular filtration rate; CESC cis rs61542988 0.570 rs62448268 chr7:22829464 G/A cg13679077 chr7:22862647 TOMM7 0.64 7.36 0.41 2.3e-12 Fibrinogen levels; CESC cis rs7071206 0.853 rs57420220 chr10:79428886 C/T cg07817648 chr10:79422355 NA -0.88 -11.32 -0.57 1.77e-24 Bone mineral density; CESC cis rs4253772 0.530 rs55653327 chr22:46682976 C/T cg10541313 chr22:46663664 TTC38 0.75 5.44 0.32 1.19e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9549367 0.773 rs9549717 chr13:113908826 A/G cg18105134 chr13:113819100 PROZ -0.69 -8.82 -0.48 1.53e-16 Platelet distribution width; CESC cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.98 0.35 7.05e-9 Colonoscopy-negative controls vs population controls; CESC cis rs5498 0.809 rs2075742 chr19:10401607 G/C cg08845333 chr19:10403403 ICAM5 0.41 5.62 0.33 4.76e-8 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg03934478 chr11:495069 RNH1 0.55 5.35 0.31 1.87e-7 Body mass index; CESC cis rs7615952 0.866 rs11922276 chr3:125631326 G/T cg05084668 chr3:125655381 ALG1L -0.47 -5.54 -0.32 7.34e-8 Blood pressure (smoking interaction); CESC cis rs9987353 0.566 rs13260067 chr8:9071033 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -5.91 -0.34 1.07e-8 Recombination measurement; CESC cis rs17601876 0.814 rs8039089 chr15:51561328 T/G cg19946085 chr15:51559439 CYP19A1 -0.33 -5.37 -0.31 1.76e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01657511 chr8:142318170 NA -0.47 -6.21 -0.36 2.07e-9 Fibrinogen levels; CESC cis rs9815354 0.761 rs73083329 chr3:41927151 C/T cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs9300255 0.602 rs1051431 chr12:123645803 G/A cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.16e-16 Neutrophil percentage of white cells; CESC cis rs3820928 1.000 rs10167422 chr2:227777554 G/A cg05526886 chr2:227700861 RHBDD1 -0.44 -5.75 -0.33 2.45e-8 Pulmonary function; CESC cis rs4803468 0.967 rs2304243 chr19:41942708 C/G cg14132834 chr19:41945861 ATP5SL 0.6 7.54 0.42 7.5e-13 Height; CESC cis rs4450798 0.739 rs9840302 chr3:13741999 C/T cg05589046 chr3:13742034 LOC285375 0.37 5.57 0.32 6.39e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs11122272 0.735 rs2437149 chr1:231490105 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -6.48 -0.37 4.51e-10 Hemoglobin concentration; CESC cis rs35110281 0.641 rs4818858 chr21:45083097 C/T cg04455712 chr21:45112962 RRP1B -0.46 -7.01 -0.4 1.93e-11 Mean corpuscular volume; CESC cis rs6460942 0.915 rs17444044 chr7:12458736 A/G cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC cis rs2832191 0.729 rs2832201 chr21:30499841 A/G cg24692254 chr21:30365293 RNF160 -0.95 -15.57 -0.69 2.9e-39 Dental caries; CESC cis rs6460942 0.591 rs62448728 chr7:12332915 A/T cg02935154 chr7:12443704 VWDE -0.53 -5.5 -0.32 9.01e-8 Coronary artery disease; CESC cis rs1707322 1.000 rs6693336 chr1:46354595 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08633134 chr19:50935017 MYBPC2 0.55 6.06 0.35 4.63e-9 Gut microbiome composition (summer); CESC cis rs1707322 0.752 rs11211152 chr1:46114157 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.12 0.4 1.04e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7923609 0.967 rs10761762 chr10:65184717 T/C cg01631684 chr10:65280961 REEP3 -0.44 -5.48 -0.32 9.84e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07247970 chr1:150293881 PRPF3 0.62 6.77 0.38 8.35e-11 Gut microbiome composition (summer); CESC cis rs9914578 0.943 rs9904872 chr17:2005241 T/A cg16513277 chr17:2031491 SMG6 -0.57 -6.62 -0.38 1.99e-10 Body mass index; CESC cis rs881375 0.934 rs2159778 chr9:123678129 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.07 0.3 7.52e-7 Rheumatoid arthritis; CESC trans rs10435719 0.610 rs76311455 chr8:11790526 C/G cg15556689 chr8:8085844 FLJ10661 0.53 6.51 0.37 3.7e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs2415984 0.622 rs61993294 chr14:46932466 C/G cg14871534 chr14:47121158 RPL10L -0.35 -5.26 -0.31 2.95e-7 Number of children ever born; CESC cis rs4704187 0.617 rs6898134 chr5:74456731 T/C cg03227963 chr5:74354835 NA 0.3 5.46 0.32 1.07e-7 Response to amphetamines; CESC cis rs798766 1.000 rs11732213 chr4:1704244 T/C cg10756475 chr4:1757242 NA -0.47 -5.77 -0.33 2.16e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg04944784 chr2:26401820 FAM59B -0.8 -8.98 -0.48 5.03e-17 Gut microbiome composition (summer); CESC cis rs2952156 0.920 rs2517954 chr17:37843550 T/C cg20243544 chr17:37824526 PNMT 0.6 7.42 0.41 1.62e-12 Asthma; CESC cis rs1344694 0.566 rs4672790 chr2:216892446 C/T cg25588852 chr2:216877276 MREG -0.36 -5.91 -0.34 1.07e-8 Alcohol dependence; CESC cis rs9309473 1.000 rs6705489 chr2:73648811 G/T cg20560298 chr2:73613845 ALMS1 -0.54 -7.2 -0.4 6.21e-12 Metabolite levels; CESC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.63 0.38 1.87e-10 Prudent dietary pattern; CESC cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.77 -11.25 -0.57 2.95e-24 Hip circumference adjusted for BMI; CESC cis rs601339 1.000 rs11059384 chr12:123170301 C/A cg11919336 chr12:123188078 GPR109A 0.45 5.86 0.34 1.36e-8 Adiponectin levels; CESC cis rs12121840 0.573 rs927844 chr1:165510312 G/T cg16553119 chr1:165599451 MGST3 0.44 5.6 0.33 5.35e-8 Interleukin-1-receptor antagonist levels; CESC cis rs710216 0.843 rs3768043 chr1:43419354 C/A cg07803811 chr1:43423981 SLC2A1 -0.46 -5.25 -0.31 3.13e-7 Red cell distribution width; CESC cis rs6831352 0.734 rs1154400 chr4:100010010 C/T cg13256891 chr4:100009986 ADH5 0.7 8.33 0.46 4.31e-15 Alcohol dependence; CESC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg21782813 chr7:2030301 MAD1L1 -0.4 -5.57 -0.32 6.23e-8 Bipolar disorder and schizophrenia; CESC cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg10523679 chr1:76189770 ACADM 0.67 7.61 0.42 4.79e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1268083 0.546 rs9398785 chr6:126057748 A/G cg05901451 chr6:126070800 HEY2 -0.53 -7.62 -0.42 4.61e-13 Migraine; CESC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.49 6.18 0.36 2.37e-9 Tonsillectomy; CESC cis rs599083 0.530 rs640569 chr11:68184820 A/G cg16797656 chr11:68205561 LRP5 -0.39 -5.18 -0.3 4.48e-7 Bone mineral density (spine); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17899198 chr3:127323650 MCM2 0.43 6.0 0.35 6.37e-9 Fibrinogen levels; CESC cis rs5769765 0.955 rs2295406 chr22:50260169 G/A cg26441486 chr22:50317300 CRELD2 -0.39 -5.51 -0.32 8.4e-8 Schizophrenia; CESC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg11987759 chr7:65425863 GUSB -0.49 -6.55 -0.37 3.03e-10 Aortic root size; CESC cis rs910316 0.789 rs4899552 chr14:75667921 C/A cg16144293 chr14:75469539 EIF2B2 0.42 5.38 0.31 1.62e-7 Height; CESC cis rs7635838 0.819 rs4684782 chr3:11518755 C/T cg00170343 chr3:11313890 ATG7 -0.42 -5.67 -0.33 3.76e-8 HDL cholesterol; CESC trans rs1814175 0.519 rs3913237 chr11:49551828 G/A cg03929089 chr4:120376271 NA 0.7 7.9 0.44 7.44e-14 Height; CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg11764359 chr7:65958608 NA 0.47 5.96 0.34 7.99e-9 Calcium levels; CESC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg02034447 chr16:89574710 SPG7 -0.46 -5.95 -0.34 8.63e-9 Multiple myeloma (IgH translocation); CESC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg08470875 chr2:26401718 FAM59B -0.75 -7.79 -0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs5757166 chr22:38995385 G/T cg21395723 chr22:39101663 GTPBP1 0.5 6.72 0.38 1.12e-10 Menopause (age at onset); CESC cis rs7520050 0.771 rs4660882 chr1:46116292 C/T cg24296786 chr1:45957014 TESK2 -0.48 -6.17 -0.35 2.58e-9 Red blood cell count;Reticulocyte count; CESC cis rs3740713 1.000 rs73440636 chr11:18473556 C/T cg23797887 chr11:18477753 LDHAL6A -0.57 -5.91 -0.34 1.06e-8 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2243480 1.000 rs316318 chr7:65612904 A/G cg18252515 chr7:66147081 NA -1.41 -14.48 -0.66 2.11e-35 Diabetic kidney disease; CESC cis rs523522 0.962 rs11065145 chr12:120947419 A/G cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg22143856 chr6:28129313 ZNF389 -0.46 -6.14 -0.35 3.05e-9 Depression; CESC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.01 9.85 0.52 1.05e-19 Platelet count; CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg24846343 chr22:24311635 DDTL 0.61 10.31 0.53 3.66e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg26850624 chr5:429559 AHRR -0.49 -6.72 -0.38 1.08e-10 Cystic fibrosis severity; CESC trans rs11098499 0.554 rs2175381 chr4:120265967 T/C cg25214090 chr10:38739885 LOC399744 0.59 7.99 0.44 4.13e-14 Corneal astigmatism; CESC cis rs2735413 0.914 rs12448754 chr16:78066747 T/C cg04733911 chr16:78082701 NA -0.49 -7.7 -0.43 2.64e-13 Systolic blood pressure (alcohol consumption interaction); CESC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg04369109 chr6:150039330 LATS1 -0.44 -6.25 -0.36 1.68e-9 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25983288 chr5:137681122 FAM53C 0.47 6.54 0.37 3.15e-10 Fibrinogen levels; CESC cis rs2712184 0.756 rs2541388 chr2:217664284 A/G cg05032264 chr2:217675019 NA 0.35 5.43 0.32 1.3e-7 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC cis rs9611565 0.694 rs5758347 chr22:41821019 G/T cg03806693 chr22:41940476 POLR3H 1.2 14.5 0.67 1.86e-35 Vitiligo; CESC cis rs7186831 1 rs7186831 chr16:75473155 G/A cg03315344 chr16:75512273 CHST6 0.42 6.12 0.35 3.38e-9 Chronic obstructive pulmonary disease; CESC cis rs2760061 0.819 rs708115 chr1:228198046 C/T cg18477163 chr1:228402036 OBSCN 0.32 5.62 0.33 4.75e-8 Diastolic blood pressure; CESC cis rs4555082 0.915 rs79048296 chr14:105754944 G/A cg13114125 chr14:105738426 BRF1 -0.89 -10.92 -0.56 3.7e-23 Mean platelet volume;Platelet distribution width; CESC cis rs977987 0.872 rs1559339 chr16:75318646 A/G cg03315344 chr16:75512273 CHST6 0.4 5.71 0.33 2.97e-8 Dupuytren's disease; CESC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.43 -5.43 -0.32 1.24e-7 Tonsillectomy; CESC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg04025307 chr7:1156635 C7orf50 0.47 7.78 0.43 1.61e-13 Longevity;Endometriosis; CESC cis rs2712184 0.756 rs2712161 chr2:217662384 G/A cg05032264 chr2:217675019 NA -0.39 -5.93 -0.34 9.65e-9 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.75 10.62 0.55 3.37e-22 Prudent dietary pattern; CESC cis rs7539624 0.588 rs10916602 chr1:223897425 G/A cg10100437 chr1:223903862 CAPN2 0.43 5.44 0.32 1.22e-7 Schizophrenia; CESC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg16145915 chr7:1198662 ZFAND2A -0.47 -6.56 -0.37 2.75e-10 Longevity;Endometriosis; CESC cis rs7520050 0.966 rs10789481 chr1:46383583 C/G cg24296786 chr1:45957014 TESK2 0.45 5.66 0.33 3.96e-8 Red blood cell count;Reticulocyte count; CESC cis rs8114671 0.562 rs4911163 chr20:33470694 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.17 0.3 4.52e-7 Height; CESC cis rs17253792 0.642 rs10483648 chr14:56104278 T/C cg01858014 chr14:56050164 KTN1 -0.96 -7.52 -0.42 8.3e-13 Putamen volume; CESC cis rs290268 0.838 rs290989 chr9:93561836 T/C cg02608019 chr9:93564028 SYK 0.63 9.64 0.51 4.92e-19 Platelet count; CESC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg12463550 chr7:65579703 CRCP 0.49 6.17 0.35 2.57e-9 Aortic root size; CESC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg18350739 chr11:68623251 NA -0.43 -6.91 -0.39 3.52e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg08859206 chr1:53392774 SCP2 -0.58 -7.51 -0.42 9.12e-13 Monocyte count; CESC cis rs367615 0.840 rs113540823 chr5:108879084 C/T cg17395555 chr5:108820864 NA 0.56 8.33 0.46 4.38e-15 Colorectal cancer (SNP x SNP interaction); CESC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.67 -0.33 3.8e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs11098499 0.562 rs2389879 chr4:120557684 G/A cg09307838 chr4:120376055 NA -0.64 -8.31 -0.45 5.07e-15 Corneal astigmatism; CESC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg00149659 chr3:10157352 C3orf10 0.71 8.36 0.46 3.63e-15 Alzheimer's disease; CESC cis rs2066819 1.000 rs41392645 chr12:56696742 A/G cg26734620 chr12:56694298 CS 1.04 6.73 0.38 1.06e-10 Psoriasis vulgaris; CESC cis rs1023500 0.573 rs133370 chr22:42465260 T/C cg15557168 chr22:42548783 NA -0.45 -6.5 -0.37 3.87e-10 Schizophrenia; CESC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg05863683 chr7:1912471 MAD1L1 0.37 5.36 0.31 1.77e-7 Bipolar disorder and schizophrenia; CESC cis rs6120849 0.707 rs3746448 chr20:33572979 C/T cg24642439 chr20:33292090 TP53INP2 0.71 6.66 0.38 1.6e-10 Protein C levels; CESC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg17949981 chr6:28129498 ZNF389 0.44 5.39 0.31 1.55e-7 Depression; CESC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg24399712 chr22:39784796 NA -0.83 -11.2 -0.57 4.21e-24 Intelligence (multi-trait analysis); CESC cis rs1881797 1.000 rs10925062 chr1:247658978 G/C cg21399703 chr1:247681439 NA 0.61 7.87 0.44 9.01e-14 Acute lymphoblastic leukemia (childhood); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27305525 chr1:154955752 FLAD1 0.5 6.49 0.37 4.12e-10 Gut microbiota (bacterial taxa); CESC cis rs2276314 0.802 rs58906216 chr18:33630297 T/C cg05985134 chr18:33552581 C18orf21 0.62 7.16 0.4 8.06e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg13628971 chr7:2884303 GNA12 -0.64 -8.62 -0.47 5.99e-16 Height; CESC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg19717773 chr7:2847554 GNA12 -0.56 -7.7 -0.43 2.64e-13 Height; CESC cis rs10899021 1.000 rs7935426 chr11:74363890 C/T cg25880958 chr11:74394337 NA -0.73 -7.19 -0.4 6.53e-12 Response to metformin (IC50); CESC cis rs7917772 0.502 rs2296583 chr10:104244322 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.65 0.43 3.63e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs3733585 0.783 rs13148371 chr4:10032561 C/T cg00071950 chr4:10020882 SLC2A9 0.88 15.98 0.7 1.01e-40 Cleft plate (environmental tobacco smoke interaction); CESC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 4.97e-9 Prudent dietary pattern; CESC cis rs208515 0.525 rs10944863 chr6:66676238 C/T cg07460842 chr6:66804631 NA 0.85 10.63 0.55 3.24e-22 Exhaled nitric oxide levels; CESC trans rs683257 0.929 rs72990194 chr6:141223008 A/G cg06418282 chr8:90913525 OSGIN2 -0.68 -6.1 -0.35 3.8e-9 Facial emotion recognition (angry faces); CESC cis rs2404602 0.647 rs12898810 chr15:76904738 T/C cg06336613 chr15:77223807 RCN2 0.41 5.18 0.3 4.49e-7 Blood metabolite levels; CESC cis rs2708240 0.791 rs2710122 chr7:147572391 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.33 -5.51 -0.32 8.58e-8 QT interval (drug interaction); CESC cis rs12477438 0.501 rs2632260 chr2:99771590 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 16.02 0.7 7.14e-41 Chronic sinus infection; CESC cis rs3859192 0.557 rs12602514 chr17:38159745 A/G cg17467752 chr17:38218738 THRA -0.43 -5.65 -0.33 4.24e-8 White blood cell count; CESC cis rs34286592 1.000 rs4787480 chr16:29857316 G/A cg27338089 chr16:29820515 MAZ 0.48 5.04 0.3 8.68e-7 Multiple sclerosis; CESC cis rs6546550 0.867 rs4401231 chr2:70063563 G/C cg02498382 chr2:70120550 SNRNP27 -0.39 -6.68 -0.38 1.37e-10 Prevalent atrial fibrillation; CESC trans rs9866054 0.681 rs10212419 chr3:139004920 A/G cg03750606 chr1:217262978 ESRRG -0.46 -6.03 -0.35 5.34e-9 Lobe attachment (rater scored); CESC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.62 8.73 0.47 2.84e-16 Bipolar disorder; CESC cis rs9840812 0.655 rs4452981 chr3:136307767 A/G cg15507776 chr3:136538369 TMEM22 0.42 5.14 0.3 5.27e-7 Fibrinogen levels; CESC cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg15485101 chr11:133734466 NA 0.41 6.63 0.38 1.88e-10 Childhood ear infection; CESC cis rs28551159 1 rs28551159 chr6:26376368 A/G cg12826209 chr6:26865740 GUSBL1 0.64 5.26 0.31 3.04e-7 Urinary tract infection frequency; CESC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg12463550 chr7:65579703 CRCP 0.58 7.41 0.41 1.67e-12 Aortic root size; CESC cis rs6912958 0.781 rs2284908 chr6:88194500 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.46 -5.99 -0.35 6.73e-9 Monocyte percentage of white cells; CESC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.55 0.37 2.98e-10 Prudent dietary pattern; CESC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.08 -0.4 1.27e-11 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23677363 chr1:111682944 DRAM2;CEPT1 -0.61 -7.56 -0.42 6.43e-13 Gut microbiome composition (summer); CESC cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg02297831 chr4:17616191 MED28 0.65 8.03 0.44 3.15e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7592578 0.640 rs56127319 chr2:191296429 G/A cg10560079 chr2:191398806 TMEM194B -0.62 -6.13 -0.35 3.22e-9 Diastolic blood pressure; CESC cis rs3820928 0.904 rs2396431 chr2:227765488 G/A cg05526886 chr2:227700861 RHBDD1 -0.44 -5.55 -0.32 6.93e-8 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09104050 chr16:68563912 NA 0.53 6.66 0.38 1.55e-10 Gut microbiome composition (summer); CESC cis rs11122272 0.735 rs2572252 chr1:231513653 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs710865 0.966 rs709683 chr1:19565344 C/G cg13387374 chr1:19411106 UBR4 0.55 7.27 0.41 3.96e-12 Brain structure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13883939 chr12:118541731 VSIG10 -0.44 -6.26 -0.36 1.52e-9 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21654404 chr12:118814431 SUDS3 0.63 7.25 0.41 4.67e-12 Gut microbiome composition (summer); CESC cis rs4132509 1.000 rs10803158 chr1:243923229 A/G cg21452805 chr1:244014465 NA 0.41 5.17 0.3 4.64e-7 RR interval (heart rate); CESC cis rs4648739 0.613 rs13303201 chr1:1903712 G/T cg04624458 chr1:1913527 KIAA1751 0.38 5.52 0.32 8.01e-8 Severe influenza A (H1N1) infection; CESC cis rs1847202 0.793 rs13088835 chr3:72949861 A/T cg10804678 chr3:72788309 NA -0.4 -5.34 -0.31 2.04e-7 Motion sickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18588052 chr6:111408752 SLC16A10 0.52 6.15 0.35 2.8e-9 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs10067021 chr5:221490 C/T cg10591111 chr5:226296 SDHA -0.51 -6.35 -0.36 9.22e-10 Breast cancer; CESC cis rs228769 0.673 rs228787 chr17:42099488 C/T cg13607699 chr17:42295918 UBTF -0.48 -5.49 -0.32 9.53e-8 Bone mineral density (hip);Bone mineral density (spine); CESC cis rs7100689 0.577 rs756208 chr10:82041751 A/G cg09936400 chr10:82049201 MAT1A 0.41 6.2 0.36 2.13e-9 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24846594 chr1:236687271 LGALS8 0.58 6.17 0.35 2.55e-9 Gut microbiome composition (summer); CESC cis rs2625529 0.730 rs6494975 chr15:72177825 T/A cg16672083 chr15:72433130 SENP8 0.44 6.35 0.36 9.26e-10 Red blood cell count; CESC cis rs2014572 0.967 rs8111977 chr19:57759158 T/A cg24459738 chr19:57751996 ZNF805 -0.53 -7.48 -0.42 1.08e-12 Hyperactive-impulsive symptoms; CESC cis rs2204008 0.840 rs3892363 chr12:38479487 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.82 0.55 7.82e-23 Bladder cancer; CESC cis rs9916302 0.706 rs11657153 chr17:37699729 A/G cg00129232 chr17:37814104 STARD3 -0.55 -5.69 -0.33 3.39e-8 Glomerular filtration rate (creatinine); CESC cis rs36051895 0.559 rs72701682 chr9:5208025 A/G cg02405213 chr9:5042618 JAK2 -0.46 -5.22 -0.31 3.67e-7 Pediatric autoimmune diseases; CESC cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg04450456 chr4:17643702 FAM184B 0.36 5.06 0.3 7.87e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg12365402 chr11:9010492 NRIP3 0.42 7.13 0.4 9.41e-12 Hemoglobin concentration; CESC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg01017244 chr2:74357527 NA 0.82 11.94 0.59 1.42e-26 Gestational age at birth (maternal effect); CESC trans rs6089829 0.816 rs6062397 chr20:61668268 A/G cg23505145 chr19:12996616 KLF1 0.51 6.68 0.38 1.37e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg23978390 chr7:1156363 C7orf50 0.6 8.41 0.46 2.63e-15 Longevity;Endometriosis; CESC cis rs897080 0.515 rs1067368 chr2:44654889 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.92 0.34 9.71e-9 Height; CESC cis rs10751667 0.666 rs10902255 chr11:967268 T/C cg20946044 chr11:1010712 AP2A2 -0.4 -5.46 -0.32 1.12e-7 Alzheimer's disease (late onset); CESC cis rs3126085 0.935 rs4845740 chr1:152183310 G/A cg26876637 chr1:152193138 HRNR 0.48 5.5 0.32 8.93e-8 Atopic dermatitis; CESC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg05332525 chr7:65337924 VKORC1L1 0.49 5.98 0.34 7.28e-9 Aortic root size; CESC cis rs3741151 0.773 rs17244616 chr11:73293112 C/T cg17517138 chr11:73019481 ARHGEF17 1.02 7.43 0.42 1.51e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg05863683 chr7:1912471 MAD1L1 0.44 6.8 0.39 6.93e-11 Bipolar disorder and schizophrenia; CESC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg24829409 chr8:58192753 C8orf71 -0.69 -7.68 -0.43 3.13e-13 Developmental language disorder (linguistic errors); CESC cis rs7605827 0.930 rs7605727 chr2:15598693 A/G cg19274914 chr2:15703543 NA 0.34 6.1 0.35 3.79e-9 Educational attainment (years of education); CESC cis rs8014204 0.804 rs35769520 chr14:75255115 G/A cg08847533 chr14:75593920 NEK9 0.47 5.97 0.34 7.75e-9 Caffeine consumption; CESC cis rs2721195 0.614 rs12719778 chr8:145879883 T/C cg15857475 chr8:145742913 RECQL4;LRRC14 0.76 10.99 0.56 2.15e-23 Age at first birth; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09400194 chr10:81107848 PPIF -0.47 -6.87 -0.39 4.65e-11 Gambling; CESC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg12963246 chr6:28129442 ZNF389 0.49 6.8 0.39 6.72e-11 Depression; CESC cis rs6032067 0.929 rs11699850 chr20:43809049 T/C cg11264863 chr20:43835661 SEMG1 0.49 5.36 0.31 1.81e-7 Blood protein levels; CESC cis rs8114671 0.570 rs3761144 chr20:33544075 C/G cg07148914 chr20:33460835 GGT7 0.41 5.28 0.31 2.75e-7 Height; CESC cis rs7666738 0.830 rs13147195 chr4:98893334 G/T cg05340658 chr4:99064831 C4orf37 0.74 10.68 0.55 2.26e-22 Colonoscopy-negative controls vs population controls; CESC cis rs4474465 0.790 rs4945290 chr11:78252249 C/T cg27205649 chr11:78285834 NARS2 0.43 5.41 0.32 1.4e-7 Alzheimer's disease (survival time); CESC cis rs67311347 0.911 rs6776044 chr3:40377503 T/G cg24209194 chr3:40518798 ZNF619 0.43 5.47 0.32 1.03e-7 Renal cell carcinoma; CESC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.1 -12.68 -0.61 4e-29 Gut microbiome composition (summer); CESC cis rs61931739 0.500 rs10844829 chr12:34304916 G/T cg19457237 chr12:34500585 NA -0.39 -5.44 -0.32 1.23e-7 Morning vs. evening chronotype; CESC cis rs501120 0.810 rs684666 chr10:44745847 T/C cg09554077 chr10:44749378 NA 0.5 6.64 0.38 1.74e-10 Coronary artery disease;Coronary heart disease; CESC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg04756594 chr16:24857601 SLC5A11 0.46 5.68 0.33 3.49e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs6912958 0.500 rs9342104 chr6:87798512 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -7.74 -0.43 2.04e-13 Monocyte percentage of white cells; CESC cis rs730566 1.000 rs4858819 chr3:48478088 C/T cg07636037 chr3:49044803 WDR6 -0.42 -5.13 -0.3 5.68e-7 Prion diseases; CESC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg21963583 chr11:68658836 MRPL21 0.4 5.63 0.33 4.63e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg21782813 chr7:2030301 MAD1L1 0.51 7.27 0.41 4.04e-12 Bipolar disorder and schizophrenia; CESC cis rs4803468 1.000 rs13344563 chr19:41945904 G/C cg09537434 chr19:41945824 ATP5SL 1.06 19.91 0.77 1.51e-54 Height; CESC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg04944784 chr2:26401820 FAM59B 0.86 9.84 0.52 1.13e-19 Gut microbiome composition (summer); CESC cis rs9303280 0.806 rs11078928 chr17:38064469 T/C cg19468946 chr17:37922297 IKZF3 -0.39 -5.07 -0.3 7.51e-7 Self-reported allergy; CESC trans rs561341 0.883 rs72821942 chr17:30234460 C/T cg27661571 chr11:113659931 NA -0.65 -6.49 -0.37 4.23e-10 Hip circumference adjusted for BMI; CESC cis rs10870270 0.830 rs11146269 chr10:133761820 G/A cg17892150 chr10:133769511 PPP2R2D -0.84 -12.23 -0.6 1.45e-27 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs10779751 0.960 rs4845988 chr1:11319587 A/G cg08854313 chr1:11322531 MTOR 0.91 14.3 0.66 9.13e-35 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21843114 chr4:26334859 RBPJ -0.61 -7.14 -0.4 9.08e-12 Gut microbiome composition (summer); CESC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg10351095 chr21:47802916 PCNT 0.49 5.82 0.34 1.73e-8 Testicular germ cell tumor; CESC cis rs6493487 0.512 rs77629026 chr15:51122225 C/T cg02338191 chr15:51200825 AP4E1 0.5 5.11 0.3 6.05e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1707322 1.000 rs4660328 chr1:46444831 G/T cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs324780 0.544 rs3110203 chr12:83884862 G/A cg22140261 chr22:42466895 NAGA 0.47 6.03 0.35 5.38e-9 Vertical cup-disc ratio; CESC cis rs4253772 0.938 rs9626814 chr22:46637254 C/T cg18190219 chr22:46762943 CELSR1 -0.49 -6.53 -0.37 3.36e-10 LDL cholesterol;Cholesterol, total; CESC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg24549020 chr5:56110836 MAP3K1 0.67 7.67 0.43 3.3e-13 Initial pursuit acceleration; CESC cis rs5758511 0.680 rs1033459 chr22:42619067 A/G cg00645731 chr22:42541494 CYP2D7P1 0.59 8.76 0.47 2.44e-16 Birth weight; CESC cis rs4664308 1.000 rs17831251 chr2:160914156 C/T cg03641300 chr2:160917029 PLA2R1 -0.68 -10.17 -0.53 9.67e-21 Idiopathic membranous nephropathy; CESC cis rs12479064 0.724 rs11885942 chr2:100004165 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -7.56 -0.42 6.67e-13 Chronic sinus infection; CESC trans rs3780486 0.846 rs10116966 chr9:33122370 T/A cg20290983 chr6:43655470 MRPS18A 0.98 18.32 0.75 5.36e-49 IgG glycosylation; CESC cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg20476274 chr7:133979776 SLC35B4 0.65 9.41 0.5 2.53e-18 Mean platelet volume; CESC cis rs854765 0.583 rs11078405 chr17:17824978 G/T cg16928487 chr17:17741425 SREBF1 -0.58 -9.9 -0.52 7.25e-20 Total body bone mineral density; CESC cis rs863345 0.527 rs7514555 chr1:158445138 G/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.16 -0.4 8.01e-12 Pneumococcal bacteremia; CESC cis rs12048904 0.964 rs8888 chr1:101338324 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 7.38 0.41 2.03e-12 Multiple sclerosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21386795 chr1:3559630 WDR8 0.46 6.46 0.37 5.07e-10 Fibrinogen levels; CESC cis rs17539620 0.624 rs117591255 chr6:154839118 G/A cg20019720 chr6:154832845 CNKSR3 0.46 6.04 0.35 5.07e-9 Lipoprotein (a) levels; CESC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg00310523 chr12:86230176 RASSF9 0.33 5.29 0.31 2.53e-7 Major depressive disorder; CESC cis rs9487051 0.768 rs458185 chr6:109524074 A/G cg01475377 chr6:109611718 NA -0.44 -6.7 -0.38 1.26e-10 Reticulocyte fraction of red cells; CESC cis rs7103648 0.695 rs12223593 chr11:47789082 T/G cg10504702 chr11:47789108 FNBP4 0.43 5.47 0.32 1.03e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg25405998 chr7:65216604 CCT6P1 0.46 5.21 0.3 3.87e-7 Aortic root size; CESC cis rs17376456 0.877 rs10059630 chr5:93459807 C/A cg21475434 chr5:93447410 FAM172A 0.82 7.56 0.42 6.81e-13 Diabetic retinopathy; CESC cis rs1881797 0.872 rs2141544 chr1:247690800 A/G cg05639522 chr1:247681581 NA 0.44 6.67 0.38 1.45e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs2425143 1.000 rs733609 chr20:34393074 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 7.72e-12 Blood protein levels; CESC cis rs2455799 0.613 rs11128762 chr3:15883439 C/T cg16303742 chr3:15540471 COLQ -0.38 -5.97 -0.34 7.75e-9 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10601548 chr6:167116288 RPS6KA2 -0.55 -6.49 -0.37 4.31e-10 Gut microbiome composition (summer); CESC cis rs4253772 0.530 rs6008662 chr22:46713917 G/A cg18190219 chr22:46762943 CELSR1 -0.47 -6.0 -0.35 6.29e-9 LDL cholesterol;Cholesterol, total; CESC cis rs7666738 0.830 rs62318504 chr4:98935558 T/G cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg04450456 chr4:17643702 FAM184B 0.37 5.23 0.31 3.4e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs877282 0.786 rs10904558 chr10:797509 C/T cg22713356 chr15:30763199 NA 1.25 13.11 0.63 1.33e-30 Uric acid levels; CESC cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg15017067 chr4:17643749 FAM184B 0.38 5.35 0.31 1.86e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs116095464 0.558 rs10060089 chr5:205565 G/A cg22857025 chr5:266934 NA -1.28 -14.21 -0.66 1.88e-34 Breast cancer; CESC cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.65 -0.43 3.85e-13 Alzheimer's disease; CESC cis rs921665 0.831 rs11682390 chr2:3187698 G/A cg02624386 chr2:3182749 NA 0.52 5.07 0.3 7.58e-7 World class endurance athleticism; CESC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg07414643 chr4:187882934 NA 0.56 8.14 0.45 1.53e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs2243480 1.000 rs2533288 chr7:66056711 C/G cg18252515 chr7:66147081 NA -1.4 -14.23 -0.66 1.55e-34 Diabetic kidney disease; CESC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg07677032 chr17:61819896 STRADA -0.48 -6.54 -0.37 3.19e-10 Prudent dietary pattern; CESC cis rs472402 0.507 rs8192139 chr5:6636973 C/G cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.45 -5.92 -0.34 1.01e-8 Response to amphetamines; CESC cis rs6540559 0.673 rs4556361 chr1:210019654 C/G cg22029157 chr1:209979665 IRF6 -0.66 -7.68 -0.43 3.11e-13 Cleft lip with or without cleft palate; CESC cis rs11676348 0.811 rs4674255 chr2:218987325 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.16 -0.35 2.74e-9 Ulcerative colitis; CESC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg00684032 chr4:1343700 KIAA1530 0.35 5.17 0.3 4.6e-7 Longevity; CESC cis rs10463316 0.894 rs13361298 chr5:150765549 T/C cg03212797 chr5:150827313 SLC36A1 -0.46 -6.04 -0.35 5.23e-9 Metabolite levels (Pyroglutamine); CESC trans rs7937682 0.883 rs12366001 chr11:111433916 A/G cg18187862 chr3:45730750 SACM1L -0.57 -6.74 -0.38 9.63e-11 Primary sclerosing cholangitis; CESC cis rs9467711 0.606 rs9358932 chr6:26362705 A/G cg14345882 chr6:26364793 BTN3A2 -0.62 -6.66 -0.38 1.54e-10 Autism spectrum disorder or schizophrenia; CESC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg18765753 chr7:1198926 ZFAND2A -0.38 -5.32 -0.31 2.2e-7 Longevity;Endometriosis; CESC cis rs1577917 1.000 rs955197 chr6:86729675 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.07 -0.35 4.48e-9 Response to antipsychotic treatment; CESC cis rs412050 0.512 rs117865454 chr22:22240214 T/C cg17089214 chr22:22089827 YPEL1 0.75 5.13 0.3 5.7e-7 Attention deficit hyperactivity disorder; CESC cis rs2933343 0.649 rs2638845 chr3:128587369 A/G cg24203234 chr3:128598194 ACAD9 0.41 5.69 0.33 3.33e-8 IgG glycosylation; CESC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg01411255 chr17:61851458 DDX42;CCDC47 1.09 19.39 0.77 9.9e-53 Height; CESC cis rs2228479 0.681 rs2270461 chr16:89972345 C/T cg00800038 chr16:89945340 TCF25 0.59 6.61 0.38 2.08e-10 Skin colour saturation; CESC cis rs17021463 0.555 rs7693950 chr4:95324901 A/T cg11021082 chr4:95130006 SMARCAD1 0.42 5.76 0.33 2.34e-8 Testicular germ cell tumor; CESC trans rs11098499 0.754 rs17595608 chr4:120250506 C/T cg25214090 chr10:38739885 LOC399744 0.62 8.81 0.48 1.69e-16 Corneal astigmatism; CESC cis rs2439831 0.867 rs2278860 chr15:43659046 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.93 -11.57 -0.58 2.55e-25 Lung cancer in ever smokers; CESC cis rs4930561 0.739 rs12225316 chr11:67976003 T/C cg16338278 chr11:67432957 ALDH3B2 0.43 5.28 0.31 2.63e-7 Breast cancer in childhood cancer survivors;IgG glycosylation; CESC trans rs393155 0.517 rs330050 chr8:9087679 G/C cg06636001 chr8:8085503 FLJ10661 -0.53 -6.82 -0.39 6.1e-11 Neuroticism; CESC cis rs7666738 0.819 rs13120307 chr4:99036100 A/C cg05340658 chr4:99064831 C4orf37 0.82 12.42 0.61 3.27e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2073300 0.609 rs12625164 chr20:23354269 T/C cg16736954 chr20:23401023 NAPB 0.79 5.84 0.34 1.5e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4132509 0.603 rs12408951 chr1:243679364 A/G cg21452805 chr1:244014465 NA 0.54 6.02 0.35 5.7e-9 RR interval (heart rate); CESC cis rs7560272 0.538 rs12619258 chr2:73935915 G/T cg20560298 chr2:73613845 ALMS1 0.43 5.84 0.34 1.51e-8 Schizophrenia; CESC cis rs35110281 0.627 rs1836855 chr21:44965414 C/G cg21573476 chr21:45109991 RRP1B -0.37 -5.12 -0.3 5.99e-7 Mean corpuscular volume; CESC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg12463550 chr7:65579703 CRCP 0.51 6.41 0.37 6.58e-10 Aortic root size; CESC cis rs2204008 0.747 rs11514040 chr12:38201040 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.59 -7.61 -0.42 4.9e-13 Prudent dietary pattern; CESC cis rs61542988 0.606 rs4722185 chr7:22832711 G/A cg13679077 chr7:22862647 TOMM7 0.64 7.27 0.41 4e-12 Fibrinogen levels; CESC trans rs561341 1.000 rs530209 chr17:30315287 A/G cg20587970 chr11:113659929 NA -1.41 -18.23 -0.75 1.08e-48 Hip circumference adjusted for BMI; CESC cis rs8017423 0.935 rs11628952 chr14:90734953 T/C cg14092571 chr14:90743983 NA 0.56 8.58 0.47 8.26e-16 Mortality in heart failure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20032723 chr11:126174041 DCPS -0.44 -6.42 -0.37 6.14e-10 Gambling; CESC cis rs2832191 0.791 rs2832197 chr21:30497790 T/C cg24692254 chr21:30365293 RNF160 -0.79 -12.11 -0.6 3.71e-27 Dental caries; CESC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.83 8.82 0.48 1.58e-16 Platelet count; CESC cis rs72781680 0.898 rs12623079 chr2:24103749 G/A cg20701182 chr2:24300061 SF3B14 0.64 5.82 0.34 1.73e-8 Lymphocyte counts; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11234017 chr17:42767172 CCDC43 0.47 6.69 0.38 1.35e-10 Systemic lupus erythematosus; CESC cis rs9788333 0.707 rs12584557 chr13:21886171 C/A cg23743428 chr13:21893420 NA -0.34 -5.92 -0.34 1.01e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2710642 0.611 rs10172216 chr2:62869546 C/G cg17519650 chr2:63277830 OTX1 0.45 5.32 0.31 2.24e-7 LDL cholesterol levels;LDL cholesterol; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12271800 chr19:59028764 ZBTB45 0.48 6.69 0.38 1.3100000000000001e-10 Fibrinogen levels; CESC trans rs61931739 0.500 rs12809868 chr12:34464905 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.49 0.54 9.45e-22 Morning vs. evening chronotype; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg27507545 chr10:103880405 LDB1 -0.46 -6.05 -0.35 4.79e-9 Height; CESC cis rs2070997 0.667 rs13287613 chr9:133715291 T/C cg11464064 chr9:133710261 ABL1 0.68 7.65 0.43 3.64e-13 Response to amphetamines; CESC cis rs2243480 1.000 rs35283677 chr7:65359233 C/T cg12463550 chr7:65579703 CRCP 0.69 5.53 0.32 7.85e-8 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17783671 chr19:59070436 UBE2M;LOC100131691 0.6 7.05 0.4 1.53e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03811478 chr3:137483696 SOX14 -0.47 -6.06 -0.35 4.75e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00752806 chr2:220462673 STK11IP -0.55 -6.28 -0.36 1.39e-9 Gut microbiome composition (summer); CESC cis rs826838 1.000 rs11183196 chr12:38685915 G/T cg26384229 chr12:38710491 ALG10B 0.84 14.75 0.67 2.36e-36 Heart rate; CESC cis rs9831754 0.756 rs1512476 chr3:78434219 G/A cg06138941 chr3:78371609 NA -0.48 -6.0 -0.35 6.33e-9 Calcium levels; CESC cis rs4780401 0.609 rs9923954 chr16:11816855 G/T cg01061890 chr16:11836724 TXNDC11 -0.56 -7.52 -0.42 8.36e-13 Rheumatoid arthritis; CESC cis rs9899728 0.665 rs2307008 chr17:73042682 G/A cg27626185 chr17:73056755 KCTD2 -0.61 -5.93 -0.34 9.6e-9 Alzheimer's disease or small vessel stroke; CESC cis rs6842047 1.000 rs72647308 chr4:187135129 G/A cg23442198 chr4:187126114 CYP4V2 -0.72 -6.02 -0.35 5.93e-9 Blood protein levels; CESC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg18180107 chr4:99064573 C4orf37 0.41 5.32 0.31 2.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4862307 0.720 rs12650935 chr4:184989565 G/A cg06737308 chr4:185021514 ENPP6 0.46 6.21 0.36 2.02e-9 Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg11843238 chr5:131593191 PDLIM4 0.35 5.17 0.3 4.72e-7 Acylcarnitine levels; CESC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg13918804 chr1:2043761 PRKCZ 0.29 5.31 0.31 2.37e-7 Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22157255 chr2:190788356 NA -0.4 -6.13 -0.35 3.24e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs2243480 1.000 rs781157 chr7:65478311 G/A cg12463550 chr7:65579703 CRCP 0.73 5.94 0.34 8.85e-9 Diabetic kidney disease; CESC trans rs1814175 0.791 rs10839468 chr11:49986288 A/G cg03929089 chr4:120376271 NA -0.94 -16.03 -0.7 7.02e-41 Height; CESC cis rs17125944 0.505 rs74642116 chr14:53213507 A/G cg13660082 chr14:53194042 PSMC6 -0.67 -5.98 -0.34 7.29e-9 Alzheimer's disease (late onset); CESC cis rs6842047 1.000 rs72647308 chr4:187135129 G/A cg02012338 chr4:187126139 CYP4V2 -0.74 -6.18 -0.35 2.4e-9 Blood protein levels; CESC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg07870213 chr5:140052090 DND1 0.6 6.33 0.36 1.05e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6582630 0.533 rs11504406 chr12:38334580 C/T cg26384229 chr12:38710491 ALG10B -0.45 -5.88 -0.34 1.23e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.67 0.64 1.52e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs116095464 0.558 rs6875291 chr5:264192 T/C cg20965017 chr5:231967 SDHA -0.48 -5.43 -0.32 1.25e-7 Breast cancer; CESC cis rs7914558 0.933 rs10786729 chr10:104719378 A/G cg15744005 chr10:104629667 AS3MT -0.35 -5.46 -0.32 1.12e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs853679 0.882 rs3757188 chr6:28107357 T/C cg18032046 chr6:28092343 ZSCAN16 -0.7 -6.28 -0.36 1.35e-9 Depression; CESC cis rs2733201 1.000 rs1160066 chr15:44410937 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11050527 chr8:54755511 ATP6V1H 0.47 6.44 0.37 5.62e-10 Systemic lupus erythematosus; CESC cis rs501120 0.810 rs498810 chr10:44740776 A/C cg09554077 chr10:44749378 NA 0.48 6.18 0.35 2.46e-9 Coronary artery disease;Coronary heart disease; CESC cis rs6964587 1.000 rs13230588 chr7:91615427 C/A cg17063962 chr7:91808500 NA 0.57 7.74 0.43 2.11e-13 Breast cancer; CESC cis rs1003719 0.591 rs2040125 chr21:38549236 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.48 6.23 0.36 1.84e-9 Eye color traits; CESC cis rs67460515 0.596 rs35589595 chr3:160930984 G/A cg03342759 chr3:160939853 NMD3 -0.55 -7.46 -0.42 1.22e-12 Parkinson's disease; CESC trans rs1814175 0.669 rs10839315 chr11:49654406 G/A cg15704280 chr7:45808275 SEPT13 -0.83 -11.45 -0.58 6.23e-25 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05485520 chr3:45883628 LZTFL1 -0.46 -6.79 -0.38 7.38e-11 Gambling; CESC cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg05347473 chr6:146136440 FBXO30 0.58 7.33 0.41 2.84e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg20999797 chr1:1681921 NA 0.28 5.42 0.32 1.36e-7 Body mass index; CESC cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg08564027 chr20:61660810 NA 0.9 15.35 0.69 1.71e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs2120019 1.000 rs2415255 chr15:75332412 A/G cg09165964 chr15:75287851 SCAMP5 -0.76 -9.18 -0.49 1.25e-17 Blood trace element (Zn levels); CESC cis rs7264396 0.563 rs17092980 chr20:34289005 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.87 0.39 4.47e-11 Total cholesterol levels; CESC cis rs67311347 1.000 rs7612015 chr3:40399974 A/C cg24209194 chr3:40518798 ZNF619 0.46 5.98 0.34 7.32e-9 Renal cell carcinoma; CESC cis rs654950 0.653 rs2810568 chr1:42054247 A/G cg06885757 chr1:42089581 HIVEP3 -0.64 -10.41 -0.54 1.63e-21 Airway imaging phenotypes; CESC cis rs1904096 0.506 rs3113863 chr4:95147827 G/C cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Type 2 diabetes; CESC cis rs3947 0.688 rs1293326 chr8:11694765 G/C cg00262122 chr8:11665843 FDFT1 -0.49 -5.22 -0.31 3.67e-7 Blood protein levels; CESC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg13206674 chr6:150067644 NUP43 0.4 5.61 0.33 4.96e-8 Lung cancer; CESC cis rs2479106 0.963 rs10986093 chr9:126494022 T/C cg16191174 chr9:126692580 DENND1A 0.49 6.68 0.38 1.38e-10 Polycystic ovary syndrome; CESC cis rs9309473 0.904 rs78450880 chr2:73821381 T/G cg20560298 chr2:73613845 ALMS1 -0.55 -7.07 -0.4 1.34e-11 Metabolite levels; CESC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg18765753 chr7:1198926 ZFAND2A -0.44 -6.37 -0.36 8.14e-10 Longevity;Endometriosis; CESC cis rs16895831 0.519 rs12200153 chr6:42577712 C/T cg10605015 chr6:42532144 UBR2 0.5 5.71 0.33 2.98e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg05754148 chr16:3507555 NAT15 -0.62 -6.1 -0.35 3.68e-9 Tuberculosis; CESC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg21724239 chr8:58056113 NA 0.6 5.56 0.32 6.59e-8 Developmental language disorder (linguistic errors); CESC cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg11366901 chr6:160182831 ACAT2 0.76 9.18 0.49 1.3e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs7178572 0.633 rs11854328 chr15:77840129 A/G cg22256960 chr15:77711686 NA -0.52 -6.62 -0.38 2e-10 Type 2 diabetes; CESC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg24549020 chr5:56110836 MAP3K1 0.68 7.76 0.43 1.85e-13 Initial pursuit acceleration; CESC cis rs644799 0.932 rs572015 chr11:95637416 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.85 12.78 0.62 1.88e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs12476592 0.602 rs10176522 chr2:63722433 T/C cg17519650 chr2:63277830 OTX1 -0.49 -5.43 -0.32 1.3e-7 Childhood ear infection; CESC cis rs7937682 0.924 rs12791699 chr11:111505880 T/C cg22437258 chr11:111473054 SIK2 0.7 9.35 0.5 3.83e-18 Primary sclerosing cholangitis; CESC cis rs854765 0.583 rs11871899 chr17:17826748 C/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.23 0.36 1.86e-9 Total body bone mineral density; CESC cis rs765787 0.530 rs2413780 chr15:45538866 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs17253792 0.731 rs74829671 chr14:56112759 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.98 0.34 7.23e-9 Putamen volume; CESC cis rs2688608 0.592 rs3849967 chr10:75483366 C/T cg23231163 chr10:75533350 FUT11 -0.34 -5.28 -0.31 2.75e-7 Inflammatory bowel disease; CESC cis rs7937682 0.855 rs539553 chr11:111477333 C/T cg09085632 chr11:111637200 PPP2R1B -0.95 -14.78 -0.67 1.84e-36 Primary sclerosing cholangitis; CESC cis rs2073300 0.609 rs6137910 chr20:23346515 C/G cg12062639 chr20:23401060 NAPB 0.98 7.59 0.42 5.37e-13 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs501120 1.000 rs622956 chr10:44755183 A/G cg09554077 chr10:44749378 NA 0.52 6.89 0.39 3.96e-11 Coronary artery disease;Coronary heart disease; CESC cis rs710216 0.917 rs900834 chr1:43412343 A/G cg07803811 chr1:43423981 SLC2A1 -0.52 -5.65 -0.33 4.1e-8 Red cell distribution width; CESC cis rs15676 1.000 rs15676 chr9:131572027 A/G cg00228799 chr9:131580591 ENDOG -0.44 -5.32 -0.31 2.26e-7 Blood metabolite levels; CESC cis rs10504229 1.000 rs59275611 chr8:58195191 G/A cg24829409 chr8:58192753 C8orf71 -0.79 -10.07 -0.53 2.04e-20 Developmental language disorder (linguistic errors); CESC cis rs2439831 0.702 rs28699233 chr15:44122866 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.64 5.15 0.3 5.16e-7 Lung cancer in ever smokers; CESC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg19901468 chr14:105411992 AHNAK2 -0.61 -8.66 -0.47 4.85e-16 Rheumatoid arthritis; CESC cis rs6466055 0.720 rs62484712 chr7:105005741 G/A cg04380332 chr7:105027541 SRPK2 -0.42 -5.51 -0.32 8.53e-8 Schizophrenia; CESC cis rs6496667 1.000 rs8023776 chr15:90897952 A/G cg22089800 chr15:90895588 ZNF774 -0.56 -5.71 -0.33 2.96e-8 Rheumatoid arthritis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24830314 chr6:83775579 UBE2CBP -0.48 -6.5 -0.37 3.86e-10 Ulcerative colitis; CESC cis rs2066819 1.000 rs2291361 chr12:56717805 G/A cg26734620 chr12:56694298 CS 1.03 6.25 0.36 1.65e-9 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25808926 chr13:21714709 SAP18 0.57 6.63 0.38 1.84e-10 Gut microbiome composition (summer); CESC cis rs1865760 0.566 rs2794720 chr6:26087202 G/C cg17691542 chr6:26056736 HIST1H1C 0.42 5.57 0.32 6.13e-8 Height; CESC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg20151795 chr6:28129481 ZNF389 0.41 5.3 0.31 2.46e-7 Depression; CESC cis rs11214589 0.620 rs34601878 chr11:113260898 G/A cg14159747 chr11:113255604 NA 0.35 6.17 0.35 2.59e-9 Neuroticism; CESC cis rs9430161 0.579 rs6694011 chr1:11036935 G/A cg02454025 chr1:11042201 C1orf127 0.93 14.49 0.66 1.93e-35 Ewing sarcoma; CESC cis rs9457247 0.967 rs388406 chr6:167409562 A/G cg25258033 chr6:167368657 RNASET2 0.4 6.14 0.35 3.04e-9 Crohn's disease; CESC cis rs2228479 0.850 rs1108063 chr16:89893983 A/G cg06558623 chr16:89946397 TCF25 1.05 7.89 0.44 8e-14 Skin colour saturation; CESC cis rs7129220 0.512 rs58652557 chr11:10121925 C/G cg01453529 chr11:10209919 SBF2 -0.48 -5.38 -0.31 1.67e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs9660180 0.967 rs61422524 chr1:1767565 C/A cg05132306 chr1:1846340 CALML6 -0.33 -6.95 -0.39 2.81e-11 Body mass index; CESC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg06108461 chr20:60628389 TAF4 -0.84 -12.68 -0.61 4.06e-29 Body mass index; CESC cis rs4853012 0.793 rs6723185 chr2:74344884 T/A cg05890377 chr2:74357713 NA 0.79 10.61 0.55 3.7e-22 Gestational age at birth (maternal effect); CESC cis rs4722166 0.603 rs7801406 chr7:22788274 A/G cg26061582 chr7:22766209 IL6 0.5 5.44 0.32 1.21e-7 Lung cancer; CESC cis rs12681366 0.663 rs2921389 chr8:95466366 G/A cg13257157 chr8:95487014 RAD54B 0.39 5.34 0.31 2.04e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.77 0.38 8.08e-11 Depression; CESC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg06287003 chr12:125626642 AACS -0.34 -5.44 -0.32 1.19e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs761746 0.705 rs2092905 chr22:31966274 T/C cg25791279 chr22:32026902 PISD -0.67 -7.52 -0.42 8.53e-13 Intelligence; CESC cis rs3747547 0.818 rs72724194 chr9:37945506 A/G cg13774184 chr9:37916125 SHB -0.58 -5.96 -0.34 7.95e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs11711311 0.747 rs7638449 chr3:113343646 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.41 5.42 0.32 1.35e-7 IgG glycosylation; CESC cis rs4523957 0.855 rs9897160 chr17:2121566 A/G cg16513277 chr17:2031491 SMG6 -0.63 -8.77 -0.47 2.29e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg14298792 chr15:30685198 CHRFAM7A 0.49 6.01 0.35 6.11e-9 Huntington's disease progression; CESC trans rs17307778 0.710 rs4415715 chr11:25357536 C/T cg22888484 chr20:37075185 SNHG11 -0.63 -6.06 -0.35 4.53e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7582720 1.000 rs72934732 chr2:203739856 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs9364687 1.000 rs6921172 chr6:163808114 C/T cg08378220 chr11:102678779 NA -0.4 -6.28 -0.36 1.39e-9 Body mass index; CESC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.05 0.3 8.43e-7 Lung cancer; CESC cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg10523679 chr1:76189770 ACADM 0.68 7.81 0.43 1.32e-13 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22469355 chr7:73082054 VPS37D 0.62 7.21 0.4 5.8e-12 Gut microbiome composition (summer); CESC trans rs2764766 0.721 rs245193 chr5:127187830 C/G cg15764593 chr10:829463 NA -0.4 -6.19 -0.36 2.3e-9 Schizophrenia; CESC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg07507251 chr3:52567010 NT5DC2 0.36 6.07 0.35 4.36e-9 Bipolar disorder; CESC trans rs877282 0.945 rs11253388 chr10:787852 A/G cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg00677455 chr12:58241039 CTDSP2 0.52 6.71 0.38 1.2e-10 Multiple sclerosis; CESC cis rs4919694 1.000 rs4919694 chr10:104698978 T/C cg04362960 chr10:104952993 NT5C2 0.71 6.21 0.36 1.99e-9 Arsenic metabolism; CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg18110333 chr6:292329 DUSP22 -0.73 -9.64 -0.51 4.77e-19 Menopause (age at onset); CESC cis rs7914558 1.000 rs12780843 chr10:104769335 G/C cg15744005 chr10:104629667 AS3MT -0.34 -5.56 -0.32 6.54e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7860634 1.000 rs7860634 chr9:139089679 C/T cg04455058 chr9:139085579 NA 0.3 5.14 0.3 5.22e-7 Thyroid hormone levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg25674709 chr12:105724273 C12orf75 0.49 6.52 0.37 3.49e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs170557 0.573 rs6657016 chr1:210114848 T/A cg22029157 chr1:209979665 IRF6 -0.41 -5.18 -0.3 4.48e-7 Alopecia areata; CESC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg18876405 chr7:65276391 NA -0.45 -6.21 -0.36 2e-9 Aortic root size; CESC cis rs919433 0.963 rs1896857 chr2:198164530 A/G cg03934865 chr2:198174659 NA -0.44 -6.28 -0.36 1.41e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs838147 0.507 rs692854 chr19:49209464 C/A cg21064579 chr19:49206444 FUT2 0.46 6.27 0.36 1.42e-9 Dietary macronutrient intake; CESC cis rs57502260 0.704 rs2306862 chr11:68177510 C/T cg20283391 chr11:68216788 NA -0.57 -5.17 -0.3 4.71e-7 Total body bone mineral density (age 45-60); CESC cis rs8070624 0.543 rs57728924 chr17:17875342 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.13 0.45 1.68e-14 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23286353 chr2:97523832 ANKRD39 0.52 6.07 0.35 4.42e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 6.5 0.37 4.07e-10 LDL cholesterol;Cholesterol, total; CESC cis rs6537837 0.793 rs17575798 chr1:110086451 G/A cg05049280 chr1:110155535 GNAT2 0.41 5.75 0.33 2.51e-8 Major depressive disorder; CESC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg26343298 chr8:95960752 TP53INP1 0.35 5.87 0.34 1.29e-8 Type 2 diabetes; CESC trans rs875971 0.638 rs801216 chr7:66011667 T/C cg26939375 chr7:64535504 NA -0.63 -8.63 -0.47 5.82e-16 Aortic root size; CESC cis rs7546094 1.000 rs7524494 chr1:113197800 A/G cg22162597 chr1:113214053 CAPZA1 -0.39 -6.01 -0.35 6.17e-9 Platelet distribution width; CESC cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg09367891 chr1:107599246 PRMT6 -0.73 -8.75 -0.47 2.52e-16 Facial morphology (factor 21, depth of nasal alae); CESC trans rs979961 0.500 rs80068177 chr4:117983735 T/C cg09069900 chr13:113776964 F10 -0.82 -6.06 -0.35 4.68e-9 Ulcerative colitis; CESC cis rs12142240 0.698 rs3991877 chr1:46853749 C/A cg10495392 chr1:46806563 NSUN4 0.56 6.15 0.35 2.86e-9 Menopause (age at onset); CESC cis rs798554 0.549 rs1623138 chr7:2899410 A/G cg19717773 chr7:2847554 GNA12 -0.49 -7.36 -0.41 2.38e-12 Height; CESC cis rs7520050 0.751 rs592214 chr1:46024505 G/A cg03146154 chr1:46216737 IPP -0.52 -6.66 -0.38 1.56e-10 Red blood cell count;Reticulocyte count; CESC cis rs6502050 0.787 rs8080682 chr17:80058901 G/A cg23985595 chr17:80112537 CCDC57 0.4 6.12 0.35 3.28e-9 Life satisfaction; CESC cis rs12681288 0.550 rs4272405 chr8:959014 C/G cg15309053 chr8:964076 NA 0.48 8.23 0.45 8.5e-15 Schizophrenia; CESC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.9e-10 Bipolar disorder; CESC cis rs7395581 0.918 rs4752825 chr11:47352409 G/A cg25783544 chr11:47291846 MADD 0.6 7.79 0.43 1.49e-13 HDL cholesterol; CESC cis rs2425143 1.000 rs6060639 chr20:34438183 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 7.86e-12 Blood protein levels; CESC cis rs1348850 0.526 rs7582179 chr2:178370631 A/G cg23306229 chr2:178417860 TTC30B 0.82 7.63 0.42 4.2e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs698833 0.962 rs698832 chr2:44734823 C/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.5 -6.25 -0.36 1.66e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs728616 0.558 rs35547640 chr10:82139150 C/T cg05935833 chr10:81318306 SFTPA2 -0.45 -5.64 -0.33 4.25e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs4688759 0.609 rs113176147 chr3:49534439 G/T cg00383909 chr3:49044727 WDR6 0.95 5.91 0.34 1.06e-8 Blood protein levels; CESC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg20887711 chr4:1340912 KIAA1530 0.42 5.73 0.33 2.78e-8 Longevity; CESC cis rs7923609 0.846 rs10740115 chr10:65094990 G/A cg01631684 chr10:65280961 REEP3 -0.42 -5.26 -0.31 3.04e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23642587 chr17:54911515 DGKE 0.6 6.48 0.37 4.36e-10 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07080049 chr9:96214194 FAM120A;FAM120AOS -0.48 -6.85 -0.39 5.19e-11 Gambling; CESC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.88 0.39 4.18e-11 Bipolar disorder; CESC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg12311346 chr5:56204834 C5orf35 -0.5 -6.2 -0.36 2.21e-9 Coronary artery disease; CESC cis rs6060717 0.536 rs6060666 chr20:34478954 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.7 0.33 3.16e-8 Hip circumference adjusted for BMI; CESC cis rs3892630 0.824 rs34425841 chr19:33231619 C/T cg22980127 chr19:33182716 NUDT19 0.99 9.44 0.5 1.98e-18 Red blood cell traits; CESC cis rs17376456 0.569 rs1349711 chr5:93179032 C/T cg25358565 chr5:93447407 FAM172A -0.71 -7.64 -0.42 3.99e-13 Diabetic retinopathy; CESC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg18758796 chr5:131593413 PDLIM4 -0.43 -5.96 -0.34 8.15e-9 Breast cancer; CESC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg22823121 chr1:150693482 HORMAD1 0.47 6.96 0.39 2.6e-11 Tonsillectomy; CESC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg17372223 chr3:52568218 NT5DC2 0.44 6.67 0.38 1.47e-10 Intelligence (multi-trait analysis); CESC cis rs11958404 0.932 rs61478293 chr5:157426299 G/A cg05962755 chr5:157440814 NA 0.59 6.54 0.37 3.09e-10 IgG glycosylation; CESC cis rs10129255 0.500 rs6576230 chr14:107186778 C/A cg07958169 chr14:107095056 NA -0.55 -8.65 -0.47 4.94e-16 Kawasaki disease; CESC trans rs34421088 0.560 rs2248325 chr8:11396874 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -6.0 -0.35 6.33e-9 Neuroticism; CESC cis rs9916302 0.904 rs2061338 chr17:37421767 T/C cg15445000 chr17:37608096 MED1 0.4 6.45 0.37 5.35e-10 Glomerular filtration rate (creatinine); CESC trans rs2727020 0.704 rs4144700 chr11:49370834 C/A cg15704280 chr7:45808275 SEPT13 -0.87 -14.54 -0.67 1.28e-35 Coronary artery disease; CESC cis rs67311347 1.000 rs73078162 chr3:40477109 G/A cg09455208 chr3:40491958 NA 0.51 8.35 0.46 3.82e-15 Renal cell carcinoma; CESC cis rs477692 0.647 rs11016853 chr10:131443990 A/G cg24747557 chr10:131355152 MGMT 0.38 5.36 0.31 1.8e-7 Response to temozolomide; CESC cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg05535760 chr7:792225 HEATR2 -0.91 -10.53 -0.54 6.78e-22 Cerebrospinal P-tau181p levels; CESC cis rs7084402 0.967 rs1649074 chr10:60295342 T/G cg07615347 chr10:60278583 BICC1 0.62 9.85 0.52 1.05e-19 Refractive error; CESC cis rs733592 0.894 rs886589 chr12:48477197 C/T cg24011408 chr12:48396354 COL2A1 -0.5 -7.62 -0.42 4.5e-13 Plateletcrit; CESC cis rs9549260 0.755 rs2721045 chr13:41162632 T/A cg21288729 chr13:41239152 FOXO1 0.63 7.87 0.44 9.15e-14 Red blood cell count; CESC cis rs2204008 0.522 rs12370263 chr12:38113311 A/G cg26384229 chr12:38710491 ALG10B 0.65 8.93 0.48 7.3e-17 Bladder cancer; CESC trans rs4332037 0.950 rs62442895 chr7:1936938 G/A cg11693508 chr17:37793320 STARD3 0.64 6.08 0.35 4.19e-9 Bipolar disorder; CESC cis rs2625529 0.652 rs8023788 chr15:72459847 A/G cg16672083 chr15:72433130 SENP8 0.49 7.35 0.41 2.47e-12 Red blood cell count; CESC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg10691866 chr7:65817282 TPST1 -0.32 -5.08 -0.3 7.15e-7 Aortic root size; CESC cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg07636037 chr3:49044803 WDR6 1.04 18.36 0.75 3.83e-49 Parkinson's disease; CESC cis rs11997175 0.583 rs66622174 chr8:33812542 T/G ch.8.33884649F chr8:33765107 NA 0.46 5.94 0.34 9.11e-9 Body mass index; CESC cis rs854765 0.583 rs7207395 chr17:17819335 C/T cg16928487 chr17:17741425 SREBF1 -0.6 -10.42 -0.54 1.58e-21 Total body bone mineral density; CESC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg04267008 chr7:1944627 MAD1L1 -0.63 -7.55 -0.42 7.17e-13 Bipolar disorder and schizophrenia; CESC cis rs4889855 0.578 rs7216808 chr17:78484187 A/G cg00066239 chr17:78472159 NA -0.38 -5.22 -0.31 3.55e-7 Fractional excretion of uric acid; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05708167 chr16:74782424 FA2H -0.51 -6.47 -0.37 4.85e-10 Gut microbiome composition (summer); CESC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg10018233 chr7:150070692 REPIN1 0.43 6.41 0.37 6.56e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.46 0.46 1.84e-15 Colonoscopy-negative controls vs population controls; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg05564625 chr6:116892562 RWDD1 0.56 7.41 0.41 1.68e-12 Myopia (pathological); CESC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg17414380 chr19:19431394 KIAA0892;SF4 0.44 5.38 0.31 1.61e-7 Tonsillectomy; CESC cis rs3733585 0.699 rs4588456 chr4:9963895 A/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs16866061 1.000 rs10933068 chr2:225418360 G/A cg12698349 chr2:225449008 CUL3 0.75 11.58 0.58 2.29e-25 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs17345786 0.906 rs72946021 chr3:101250008 T/G cg12386194 chr3:101231763 SENP7 0.59 6.53 0.37 3.42e-10 Colonoscopy-negative controls vs population controls; CESC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg12963246 chr6:28129442 ZNF389 0.54 6.89 0.39 4.02e-11 Parkinson's disease; CESC cis rs9916302 0.800 rs9892675 chr17:37549200 C/T cg00129232 chr17:37814104 STARD3 0.51 5.65 0.33 4.18e-8 Glomerular filtration rate (creatinine); CESC cis rs7020830 0.867 rs56098516 chr9:37362220 A/G cg14294708 chr9:37120828 ZCCHC7 1.11 19.1 0.76 9.61e-52 Schizophrenia; CESC cis rs9488822 0.636 rs1544155 chr6:116346394 C/A cg05304507 chr6:116381966 FRK 0.26 6.59 0.38 2.37e-10 Cholesterol, total;LDL cholesterol; CESC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg08027265 chr7:2291960 NA -0.46 -7.08 -0.4 1.27e-11 Bipolar disorder and schizophrenia; CESC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg00129232 chr17:37814104 STARD3 0.59 7.82 0.43 1.22e-13 Glomerular filtration rate (creatinine); CESC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg17372223 chr3:52568218 NT5DC2 0.44 6.59 0.38 2.34e-10 Bipolar disorder; CESC cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg03060546 chr3:49711283 APEH 0.43 5.27 0.31 2.84e-7 Parkinson's disease; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg03984859 chr1:165668066 ALDH9A1 -0.45 -6.03 -0.35 5.51e-9 Thyroid stimulating hormone; CESC cis rs34172651 0.917 rs11642302 chr16:24770856 G/A cg06028605 chr16:24865363 SLC5A11 0.35 5.44 0.32 1.2e-7 Intelligence (multi-trait analysis); CESC cis rs17376456 0.877 rs10476599 chr5:93383423 A/G cg25358565 chr5:93447407 FAM172A 1.11 10.64 0.55 2.98e-22 Diabetic retinopathy; CESC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg27266060 chr8:22091797 NA 0.38 7.85 0.43 1.04e-13 Hypertriglyceridemia; CESC cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 11.39 0.57 1.01e-24 Hip circumference adjusted for BMI; CESC cis rs1003719 0.679 rs1133001 chr21:38512956 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.06 -0.44 2.56e-14 Eye color traits; CESC cis rs12701220 0.689 rs12533004 chr7:1095410 C/T cg26769984 chr7:1090371 C7orf50 0.58 5.99 0.35 6.9e-9 Bronchopulmonary dysplasia; CESC cis rs748404 0.631 rs6493086 chr15:43655394 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.54 8.3 0.45 5.5e-15 Lung cancer; CESC trans rs7726839 0.718 rs6887972 chr5:597274 C/G cg25482853 chr8:67687455 SGK3 0.62 6.36 0.36 8.59e-10 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00307266 chr5:31532303 RNASEN;C5orf22 0.55 6.23 0.36 1.79e-9 Gut microbiome composition (summer); CESC cis rs9399135 1.000 rs11754265 chr6:135356216 C/G cg22676075 chr6:135203613 NA 0.49 6.89 0.39 4.05e-11 Red blood cell count; CESC trans rs1814175 0.615 rs10839378 chr11:49806943 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -6.08 -0.35 4.23e-9 Height; CESC cis rs1707322 0.752 rs10430105 chr1:46138876 G/A cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6912958 0.754 rs7762864 chr6:88236213 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.37 -6.01 -0.35 6.1e-9 Monocyte percentage of white cells; CESC cis rs8180040 0.593 rs10433549 chr3:47031433 C/T cg27129171 chr3:47204927 SETD2 -0.66 -9.62 -0.51 5.48e-19 Colorectal cancer; CESC cis rs3771570 1.000 rs4346380 chr2:242263223 G/A cg21155796 chr2:242212141 HDLBP 0.6 5.12 0.3 5.96e-7 Prostate cancer; CESC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg18099408 chr3:52552593 STAB1 -0.3 -5.05 -0.3 8.07e-7 Bipolar disorder; CESC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.59 7.71 0.43 2.62e-13 Menopause (age at onset); CESC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg04166393 chr7:2884313 GNA12 0.53 6.66 0.38 1.61e-10 Height; CESC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg21770322 chr7:97807741 LMTK2 0.56 8.61 0.47 6.55e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs12142240 0.698 rs6696777 chr1:46810970 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.29 0.36 1.33e-9 Menopause (age at onset); CESC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg08736216 chr1:53307985 ZYG11A -0.41 -6.69 -0.38 1.34e-10 Monocyte count; CESC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg12311346 chr5:56204834 C5orf35 -0.45 -5.53 -0.32 7.82e-8 Coronary artery disease; CESC cis rs4604732 0.631 rs76761880 chr1:247626377 T/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg07677032 chr17:61819896 STRADA 0.46 6.21 0.36 2.06e-9 Prudent dietary pattern; CESC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg21724239 chr8:58056113 NA 0.6 5.33 0.31 2.12e-7 Developmental language disorder (linguistic errors); CESC cis rs826838 0.684 rs12367400 chr12:38618673 G/T cg13010199 chr12:38710504 ALG10B 0.53 6.89 0.39 4.13e-11 Heart rate; CESC cis rs1707322 0.717 rs2253862 chr1:46081960 C/T cg05343316 chr1:45956843 TESK2 -0.53 -6.5 -0.37 3.98e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg05564831 chr3:52568323 NT5DC2 -0.41 -6.02 -0.35 5.65e-9 Bipolar disorder; CESC cis rs7927771 1.000 rs11039255 chr11:47495746 G/T cg18512352 chr11:47633146 NA -0.58 -8.64 -0.47 5.56e-16 Subjective well-being; CESC cis rs1879734 0.731 rs7555711 chr1:54158220 A/G cg23596471 chr1:54105337 GLIS1 0.35 5.67 0.33 3.77e-8 Mitral valve prolapse; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19980912 chr5:133304180 C5orf15 0.6 6.87 0.39 4.63e-11 Gut microbiome composition (summer); CESC trans rs7615952 0.932 rs7629977 chr3:125649573 T/G cg07211511 chr3:129823064 LOC729375 -1.1 -14.44 -0.66 2.92e-35 Blood pressure (smoking interaction); CESC cis rs9549367 0.789 rs2287253 chr13:113891075 G/A cg18105134 chr13:113819100 PROZ 0.57 6.97 0.39 2.58e-11 Platelet distribution width; CESC cis rs2249625 0.564 rs2496496 chr6:72884053 A/G cg18830697 chr6:72922368 RIMS1 -0.46 -6.81 -0.39 6.53e-11 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg12463550 chr7:65579703 CRCP -0.57 -7.4 -0.41 1.79e-12 Aortic root size; CESC cis rs4253772 0.515 rs7287164 chr22:46781008 T/C cg18190219 chr22:46762943 CELSR1 -0.68 -6.09 -0.35 3.89e-9 LDL cholesterol;Cholesterol, total; CESC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg26335602 chr6:28129616 ZNF389 0.37 5.52 0.32 7.92e-8 Cardiac Troponin-T levels; CESC cis rs11098499 0.863 rs2306456 chr4:120472422 C/G cg09307838 chr4:120376055 NA 0.91 12.68 0.61 4e-29 Corneal astigmatism; CESC cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg12927641 chr6:109611667 NA -0.4 -6.31 -0.36 1.18e-9 Reticulocyte fraction of red cells; CESC cis rs6582630 0.576 rs2222345 chr12:38356020 G/A cg26384229 chr12:38710491 ALG10B -0.47 -6.07 -0.35 4.34e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs2806561 0.734 rs10799788 chr1:23356864 G/A cg12483005 chr1:23474871 LUZP1 0.34 5.23 0.31 3.44e-7 Height; CESC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg02221750 chr19:17393354 ANKLE1 -0.5 -6.0 -0.35 6.45e-9 Systemic lupus erythematosus; CESC cis rs1865721 0.771 rs72975988 chr18:73128289 T/G cg26385618 chr18:73139727 C18orf62 -0.52 -8.29 -0.45 5.91e-15 Intelligence; CESC trans rs6715284 0.892 rs56828879 chr2:202241323 T/C cg00425217 chr19:13205470 NFIX -0.6 -6.0 -0.35 6.38e-9 Rheumatoid arthritis; CESC cis rs7520050 0.966 rs12021587 chr1:46472759 G/T cg24296786 chr1:45957014 TESK2 0.44 5.5 0.32 9.17e-8 Red blood cell count;Reticulocyte count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17375167 chr15:99192228 IGF1R 0.46 6.15 0.35 2.79e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10224311 chr22:35817371 MCM5 -0.41 -6.02 -0.35 5.64e-9 Gut microbiota (bacterial taxa); CESC cis rs10838687 0.800 rs4752983 chr11:47352138 C/T cg25783544 chr11:47291846 MADD 0.55 6.23 0.36 1.8e-9 Proinsulin levels; CESC cis rs6500602 0.627 rs4786494 chr16:4506232 G/A cg08645402 chr16:4508243 NA 0.45 6.43 0.37 5.96e-10 Schizophrenia; CESC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 -1.03 -10.77 -0.55 1.13e-22 Platelet count; CESC cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg18876405 chr7:65276391 NA 0.62 8.1 0.45 2e-14 Aortic root size; CESC cis rs1949733 0.598 rs16842480 chr4:8535621 G/T cg11789530 chr4:8429930 ACOX3 -0.61 -7.96 -0.44 5.13e-14 Response to antineoplastic agents; CESC cis rs4253772 0.550 rs739164 chr22:46684558 C/T cg18190219 chr22:46762943 CELSR1 0.48 6.21 0.36 2.09e-9 LDL cholesterol;Cholesterol, total; CESC cis rs12142240 0.698 rs56358525 chr1:46849520 C/T cg10495392 chr1:46806563 NSUN4 0.56 6.15 0.35 2.86e-9 Menopause (age at onset); CESC cis rs4720575 0.931 rs10242850 chr7:47099868 A/C cg00036614 chr7:47093842 NA -0.42 -6.48 -0.37 4.39e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs10088262 0.629 rs7828192 chr8:124804669 C/T cg20713898 chr8:124780851 FAM91A1 -0.64 -8.51 -0.46 1.27e-15 Pancreatic cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26728986 chr19:45540955 SFRS16;RELB 0.52 7.08 0.4 1.31e-11 Fibrinogen levels; CESC cis rs3820068 0.580 rs12082523 chr1:16005792 A/G cg17385448 chr1:15911702 AGMAT -0.38 -6.17 -0.35 2.61e-9 Systolic blood pressure; CESC cis rs9389248 0.690 rs728030 chr6:135246294 G/T cg24558204 chr6:135376177 HBS1L -0.63 -8.88 -0.48 1e-16 High light scatter reticulocyte percentage of red cells; CESC cis rs11098499 0.863 rs3775843 chr4:120427844 T/C cg24375607 chr4:120327624 NA 0.44 5.23 0.31 3.48e-7 Corneal astigmatism; CESC cis rs6964587 1.000 rs11982213 chr7:91722966 A/G cg17063962 chr7:91808500 NA 0.56 7.73 0.43 2.31e-13 Breast cancer; CESC cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg22875332 chr1:76189707 ACADM 0.63 7.33 0.41 2.78e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg07308232 chr7:1071921 C7orf50 -0.44 -6.0 -0.35 6.58e-9 Longevity;Endometriosis; CESC cis rs12765878 1.000 rs3814220 chr10:105647300 A/G cg24587175 chr10:105670608 OBFC1 0.32 5.16 0.3 4.78e-7 Coronary artery disease; CESC cis rs12477438 0.765 rs6735801 chr2:99657995 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs7959452 0.535 rs10784771 chr12:69621264 A/G cg14784868 chr12:69753453 YEATS4 0.72 10.24 0.53 5.76e-21 Blood protein levels; CESC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.02 0.59 7.31e-27 Alzheimer's disease; CESC cis rs17023223 0.537 rs11487668 chr1:119726796 T/C cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs4720575 0.868 rs7779776 chr7:47092914 C/G cg00036614 chr7:47093842 NA -0.43 -6.65 -0.38 1.69e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs7666738 0.830 rs17027102 chr4:98919221 A/G cg05340658 chr4:99064831 C4orf37 -0.76 -11.4 -0.57 9.42e-25 Colonoscopy-negative controls vs population controls; CESC cis rs4423214 1.000 rs7935125 chr11:71184190 C/A cg05163923 chr11:71159392 DHCR7 0.8 10.72 0.55 1.69e-22 Vitamin D levels; CESC cis rs9549260 0.664 rs9532575 chr13:41225361 G/C cg21288729 chr13:41239152 FOXO1 0.65 8.5 0.46 1.4e-15 Red blood cell count; CESC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg00484396 chr16:3507460 NAT15 0.44 7.35 0.41 2.39e-12 Tuberculosis; CESC cis rs131777 0.577 rs5770928 chr22:51029091 G/C cg25309564 chr22:51001381 C22orf41 0.64 8.1 0.45 2.03e-14 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs11098499 0.913 rs11098496 chr4:120167466 C/G cg24375607 chr4:120327624 NA 0.44 5.28 0.31 2.66e-7 Corneal astigmatism; CESC cis rs477692 0.905 rs693402 chr10:131422882 G/A cg05714579 chr10:131428358 MGMT 0.57 8.16 0.45 1.36e-14 Response to temozolomide; CESC cis rs2749592 0.550 rs4934881 chr10:37914346 A/C cg25427524 chr10:38739819 LOC399744 0.58 7.96 0.44 5.09e-14 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6570726 0.935 rs425731 chr6:145834151 A/G cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs10791323 0.593 rs2282604 chr11:133714672 A/G cg15485101 chr11:133734466 NA 0.39 6.57 0.37 2.63e-10 Childhood ear infection; CESC cis rs3925075 0.966 rs12935192 chr16:31359330 G/A cg02846316 chr16:31340340 ITGAM 0.42 6.65 0.38 1.66e-10 IgA nephropathy; CESC cis rs4727963 0.846 rs4731083 chr7:122725490 G/C cg03640110 chr7:122635026 TAS2R16 -0.37 -5.62 -0.33 4.72e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs10779751 0.770 rs12097293 chr1:11197467 A/G cg08854313 chr1:11322531 MTOR -0.7 -8.35 -0.46 3.85e-15 Body mass index; CESC cis rs1595825 0.786 rs75619425 chr2:198537281 A/G cg10820045 chr2:198174542 NA 0.42 5.23 0.31 3.4e-7 Ulcerative colitis; CESC cis rs708547 0.836 rs1718882 chr4:57859533 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.6 -7.36 -0.41 2.25e-12 Response to bleomycin (chromatid breaks); CESC cis rs2228479 0.850 rs11640188 chr16:89807732 C/T cg04013166 chr16:89971882 TCF25 0.77 6.63 0.38 1.9e-10 Skin colour saturation; CESC cis rs11048434 0.736 rs12423746 chr12:9113002 G/T cg23795048 chr12:9217529 LOC144571 0.34 5.32 0.31 2.2e-7 Sjögren's syndrome; CESC cis rs2749592 0.505 rs7915670 chr10:37870212 T/C cg25427524 chr10:38739819 LOC399744 0.55 7.6 0.42 5.27e-13 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs709400 1.000 rs61995780 chr14:104120612 A/G cg12935359 chr14:103987150 CKB -0.45 -6.09 -0.35 3.94e-9 Body mass index; CESC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg06221963 chr1:154839813 KCNN3 0.38 5.55 0.32 6.92e-8 Schizophrenia; CESC trans rs57221529 0.766 rs12519763 chr5:559145 C/T cg25482853 chr8:67687455 SGK3 1.11 11.94 0.59 1.39e-26 Lung disease severity in cystic fibrosis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01737828 chr15:75230659 COX5A -0.4 -6.03 -0.35 5.41e-9 Gambling; CESC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg19346786 chr7:2764209 NA -0.45 -6.51 -0.37 3.68e-10 Height; CESC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg08027265 chr7:2291960 NA -0.46 -7.01 -0.4 2.02e-11 Bipolar disorder and schizophrenia; CESC cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.63 6.47 0.37 4.82e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05998816 chr21:47859926 PCNT -0.61 -7.67 -0.43 3.31e-13 Gut microbiome composition (summer); CESC cis rs9910055 0.659 rs112114764 chr17:42201041 G/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.66 -8.84 -0.48 1.36e-16 Total body bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27265637 chr10:75504303 SEC24C 0.49 6.91 0.39 3.6e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg16339924 chr4:17578868 LAP3 0.7 8.84 0.48 1.33e-16 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2115630 0.645 rs3825878 chr15:85174755 C/T cg11189052 chr15:85197271 WDR73 -0.5 -6.84 -0.39 5.31e-11 P wave terminal force; CESC cis rs10883723 0.810 rs7090034 chr10:104281155 C/G cg22532475 chr10:104410764 TRIM8 -0.33 -5.67 -0.33 3.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs2952156 0.834 rs903503 chr17:37829571 C/A cg00129232 chr17:37814104 STARD3 -0.81 -11.81 -0.59 3.71e-26 Asthma; CESC cis rs10751667 0.577 rs7946461 chr11:974035 A/G cg06064525 chr11:970664 AP2A2 -0.46 -8.92 -0.48 7.68e-17 Alzheimer's disease (late onset); CESC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg24562669 chr7:97807699 LMTK2 0.48 6.92 0.39 3.3e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs9457247 1.000 rs415842 chr6:167406681 G/A cg25258033 chr6:167368657 RNASET2 0.39 5.89 0.34 1.15e-8 Crohn's disease; CESC cis rs5769765 0.825 rs9616780 chr22:50292763 T/C cg02269571 chr22:50332266 NA -0.45 -6.05 -0.35 4.98e-9 Schizophrenia; CESC cis rs9486719 1.000 rs12214469 chr6:97019471 G/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.7 -0.33 3.16e-8 Migraine;Coronary artery disease; CESC cis rs8053891 0.756 rs9925462 chr16:72000195 C/G cg04254540 chr16:71951199 KIAA0174 -0.42 -5.41 -0.32 1.39e-7 Coronary artery disease; CESC cis rs17253792 0.642 rs10483648 chr14:56104278 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.65 0.33 4.2e-8 Putamen volume; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg22185043 chr18:12947723 SEH1L -0.41 -6.17 -0.35 2.48e-9 Breast cancer; CESC trans rs853679 0.546 rs200989 chr6:27816442 A/G cg06606381 chr12:133084897 FBRSL1 -0.82 -7.7 -0.43 2.68e-13 Depression; CESC cis rs2073300 0.609 rs77908916 chr20:23405626 C/G cg12062639 chr20:23401060 NAPB 1.06 8.07 0.44 2.51e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs977987 0.898 rs12918974 chr16:75493943 T/A cg03315344 chr16:75512273 CHST6 0.54 7.77 0.43 1.75e-13 Dupuytren's disease; CESC cis rs2073300 0.609 rs6132605 chr20:23354839 A/C cg16736954 chr20:23401023 NAPB 0.79 5.84 0.34 1.5e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9814567 1.000 rs6800862 chr3:134228628 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.44 -0.32 1.24e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs644799 0.601 rs7902 chr11:95565288 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.53 7.48 0.42 1.09e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3809863 0.602 rs6504833 chr17:45396087 A/G cg25173405 chr17:45401733 C17orf57 -0.55 -7.18 -0.4 7.16e-12 Glaucoma (primary open-angle); CESC cis rs11030122 0.661 rs4910877 chr11:4062153 A/G cg18678763 chr11:4115507 RRM1 -0.41 -5.48 -0.32 9.72e-8 Mean platelet volume;Platelet distribution width; CESC cis rs2880765 0.835 rs4842887 chr15:86035810 T/C cg10818794 chr15:86012489 AKAP13 -0.34 -5.27 -0.31 2.8e-7 Coronary artery disease; CESC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg18876405 chr7:65276391 NA -0.54 -7.06 -0.4 1.46e-11 Aortic root size; CESC cis rs2243480 0.666 rs1880311 chr7:65276752 G/C cg12463550 chr7:65579703 CRCP -0.72 -5.61 -0.33 5.07e-8 Diabetic kidney disease; CESC cis rs6785206 0.772 rs2811493 chr3:128357299 C/G cg16766828 chr3:128327626 NA -0.6 -5.96 -0.34 8.15e-9 Lymphocyte percentage of white cells; CESC cis rs9322193 0.962 rs9688750 chr6:149978769 T/C cg07701084 chr6:150067640 NUP43 0.43 5.94 0.34 8.9e-9 Lung cancer; CESC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs1953600 0.870 rs2236557 chr10:81923961 A/G cg00277334 chr10:82204260 NA 0.44 6.06 0.35 4.76e-9 Sarcoidosis; CESC cis rs4969178 1.000 rs7212201 chr17:76393896 C/A cg20026190 chr17:76395443 PGS1 0.48 7.7 0.43 2.68e-13 HDL cholesterol levels; CESC cis rs5758659 1.000 rs134882 chr22:42670965 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.3 -5.15 -0.3 5.17e-7 Cognitive function; CESC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.09 -0.35 3.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11098499 0.954 rs13145352 chr4:120409963 C/T cg25214090 chr10:38739885 LOC399744 -0.69 -9.21 -0.49 1.06e-17 Corneal astigmatism; CESC cis rs12142240 0.698 rs56284503 chr1:46847127 C/G cg10495392 chr1:46806563 NSUN4 0.56 6.15 0.35 2.86e-9 Menopause (age at onset); CESC cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.08e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.15 0.4 8.38e-12 Electroencephalogram traits; CESC cis rs10751667 1.000 rs11246359 chr11:967943 T/C cg06064525 chr11:970664 AP2A2 -0.38 -6.77 -0.38 8.29e-11 Alzheimer's disease (late onset); CESC cis rs6840258 1.000 rs72667754 chr4:87942061 T/C cg08197287 chr4:87952173 AFF1 -0.41 -5.57 -0.32 6.14e-8 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs1018836 0.923 rs2157607 chr8:91600268 A/G cg16814680 chr8:91681699 NA -0.69 -9.45 -0.5 1.83e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs11711311 0.747 rs9882193 chr3:113349451 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.38 -5.05 -0.3 8.1e-7 IgG glycosylation; CESC cis rs9549260 0.755 rs2701863 chr13:41170140 C/T cg21288729 chr13:41239152 FOXO1 0.59 7.35 0.41 2.53e-12 Red blood cell count; CESC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.53 -7.02 -0.4 1.88e-11 Menarche (age at onset); CESC cis rs10845606 1.000 rs11055013 chr12:12829037 T/C cg09462578 chr12:12878428 APOLD1 -0.63 -6.94 -0.39 3.05e-11 Systemic lupus erythematosus; CESC cis rs2180341 1.000 rs6569486 chr6:127708424 A/C cg24812749 chr6:127587940 RNF146 1.03 14.56 0.67 1.13e-35 Breast cancer; CESC cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg24642439 chr20:33292090 TP53INP2 0.64 8.27 0.45 6.39e-15 Coronary artery disease; CESC cis rs35955747 0.869 rs9621216 chr22:31590208 A/C cg25791279 chr22:32026902 PISD -0.45 -5.3 -0.31 2.5e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs1256061 0.533 rs2357479 chr14:64792764 G/T cg23250157 chr14:64679961 SYNE2 0.52 7.26 0.41 4.25e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs3125734 0.633 rs6479791 chr10:63980341 T/C cg09941381 chr10:64027924 RTKN2 -0.32 -5.34 -0.31 2e-7 Rheumatoid arthritis; CESC trans rs208520 0.690 rs1233103 chr6:66855943 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.93 -0.62 5.39e-30 Exhaled nitric oxide output; CESC cis rs4919087 0.892 rs10882880 chr10:99008068 G/A cg25902810 chr10:99078978 FRAT1 0.65 9.33 0.5 4.51e-18 Monocyte count; CESC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg24399712 chr22:39784796 NA -0.81 -11.11 -0.56 8.72e-24 Intelligence (multi-trait analysis); CESC cis rs7945705 0.870 rs10840142 chr11:8906078 A/G cg12365402 chr11:9010492 NRIP3 0.38 5.82 0.34 1.66e-8 Hemoglobin concentration; CESC cis rs12950390 0.893 rs4794110 chr17:45847230 A/G cg00777063 chr17:45855553 NA -0.41 -6.24 -0.36 1.72e-9 IgG glycosylation; CESC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg01988459 chr11:68622903 NA -0.44 -6.14 -0.35 3.07e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs61931739 0.517 rs1843735 chr12:34047389 C/G cg26384229 chr12:38710491 ALG10B 0.51 6.94 0.39 2.97e-11 Morning vs. evening chronotype; CESC cis rs2985684 0.894 rs6572585 chr14:50021075 A/G cg02151108 chr14:50098012 C14orf104 -0.39 -5.19 -0.3 4.16e-7 Carotid intima media thickness; CESC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.86 9.19 0.49 1.15e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7659604 0.689 rs59131059 chr4:122666357 C/T cg19671926 chr4:122722719 EXOSC9 -0.49 -5.94 -0.34 9.04e-9 Type 2 diabetes; CESC cis rs7116495 0.609 rs1892920 chr11:71702431 A/G cg10381502 chr11:71823885 C11orf51 -1.13 -7.5 -0.42 9.35e-13 Severe influenza A (H1N1) infection; CESC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg06634786 chr22:41940651 POLR3H 0.62 6.81 0.39 6.4e-11 Vitiligo; CESC cis rs977987 0.806 rs11865004 chr16:75395777 C/T cg03315344 chr16:75512273 CHST6 0.39 5.64 0.33 4.3e-8 Dupuytren's disease; CESC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg13206674 chr6:150067644 NUP43 0.44 6.29 0.36 1.27e-9 Lung cancer; CESC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 -0.73 -6.87 -0.39 4.48e-11 Platelet count; CESC cis rs3015497 0.646 rs2934687 chr14:51111889 G/A cg26011998 chr14:51135199 SAV1 -0.6 -6.73 -0.38 1.02e-10 Mean platelet volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24480577 chr20:62169334 PTK6 -0.48 -7.22 -0.41 5.6e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs854765 0.551 rs8070748 chr17:17859421 A/G cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC cis rs6674176 0.542 rs803679 chr1:44349405 G/A cg12908607 chr1:44402522 ARTN -0.41 -5.5 -0.32 9.08e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.4 0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11039798 0.588 rs3924476 chr11:48581733 T/C cg15704280 chr7:45808275 SEPT13 0.63 6.57 0.37 2.69e-10 Axial length; CESC cis rs11758351 0.929 rs6906367 chr6:26187125 C/T cg23601095 chr6:26197514 HIST1H3D 0.58 6.5 0.37 3.95e-10 Gout;Renal underexcretion gout; CESC cis rs1552244 0.554 rs3732963 chr3:10048885 G/T cg00149659 chr3:10157352 C3orf10 0.53 6.51 0.37 3.81e-10 Alzheimer's disease; CESC cis rs1448094 0.511 rs2405621 chr12:86149336 A/T cg02569458 chr12:86230093 RASSF9 -0.42 -6.46 -0.37 4.89e-10 Major depressive disorder; CESC cis rs7904368 0.806 rs12242261 chr10:16872929 T/C cg23933602 chr10:16859644 RSU1 0.62 5.71 0.33 3.05e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs7143963 0.697 rs2273393 chr14:103357603 G/T cg24154132 chr14:103367632 TRAF3 0.38 6.71 0.38 1.18e-10 Body mass index; CESC cis rs6066835 0.702 rs6095229 chr20:47283774 C/T cg18078177 chr20:47281410 PREX1 0.72 5.08 0.3 7.06e-7 Multiple myeloma; CESC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs7520050 0.931 rs11211213 chr1:46342517 G/A cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.4e-7 Red blood cell count;Reticulocyte count; CESC cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg19077165 chr18:44547161 KATNAL2 0.52 7.39 0.41 1.91e-12 Personality dimensions; CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.07 0.3 7.56e-7 Bipolar disorder; CESC cis rs8180040 0.764 rs4082155 chr3:47125385 G/A cg27129171 chr3:47204927 SETD2 0.7 10.51 0.54 7.71e-22 Colorectal cancer; CESC cis rs992157 0.764 rs13020391 chr2:219184436 C/T cg00012203 chr2:219082015 ARPC2 -0.59 -7.19 -0.4 6.77e-12 Colorectal cancer; CESC cis rs9457247 1.000 rs400837 chr6:167411008 T/C cg23791538 chr6:167370224 RNASET2 -0.61 -8.81 -0.48 1.71e-16 Crohn's disease; CESC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg22508957 chr16:3507546 NAT15 0.72 7.69 0.43 2.82e-13 Tuberculosis; CESC cis rs80282103 0.618 rs10794720 chr10:1156165 A/G cg24064224 chr10:1156594 WDR37 0.45 5.44 0.32 1.24e-7 Glomerular filtration rate (creatinine); CESC cis rs733592 0.524 rs10875726 chr12:48425992 A/G cg24011408 chr12:48396354 COL2A1 -0.51 -8.59 -0.47 7.74e-16 Plateletcrit; CESC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg04944784 chr2:26401820 FAM59B -0.93 -10.75 -0.55 1.28e-22 Gut microbiome composition (summer); CESC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg19717773 chr7:2847554 GNA12 -0.57 -8.13 -0.45 1.66e-14 Height; CESC cis rs807669 0.934 rs1780643 chr22:19191725 T/C cg02655711 chr22:19163373 SLC25A1 0.96 14.07 0.65 5.72e-34 Metabolite levels; CESC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg04369109 chr6:150039330 LATS1 -0.39 -5.28 -0.31 2.65e-7 Lung cancer; CESC cis rs2735413 0.918 rs2344494 chr16:78078111 C/T cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg04317338 chr11:64019027 PLCB3 0.87 9.06 0.49 3.04e-17 Mean platelet volume; CESC cis rs763121 0.651 rs738249 chr22:39037979 T/C cg21395723 chr22:39101663 GTPBP1 0.42 5.21 0.3 3.82e-7 Menopause (age at onset); CESC cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg05347473 chr6:146136440 FBXO30 0.57 7.24 0.41 4.72e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1401999 0.899 rs2313211 chr3:183738626 T/A cg01324343 chr3:183735012 ABCC5 0.67 14.52 0.67 1.5e-35 Anterior chamber depth; CESC cis rs2235544 0.541 rs928442 chr1:54473488 C/G cg25741118 chr1:54482237 LDLRAD1 -0.25 -6.28 -0.36 1.41e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC trans rs61931739 0.500 rs10844848 chr12:34409705 A/C cg26384229 chr12:38710491 ALG10B 0.7 10.43 0.54 1.43e-21 Morning vs. evening chronotype; CESC cis rs9399401 1.000 rs1040525 chr6:142703669 C/T cg03128060 chr6:142623767 GPR126 0.26 5.24 0.31 3.31e-7 Chronic obstructive pulmonary disease; CESC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg04025307 chr7:1156635 C7orf50 0.48 7.73 0.43 2.31e-13 Longevity;Endometriosis; CESC cis rs17655565 0.533 rs12301094 chr12:52707610 A/G cg08257133 chr12:52711352 KRT83 0.5 8.85 0.48 1.25e-16 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg18252515 chr7:66147081 NA -0.43 -5.94 -0.34 8.95e-9 Aortic root size; CESC cis rs1728785 0.892 rs1103955 chr16:68588488 T/G cg02972257 chr16:68554789 NA -0.58 -6.68 -0.38 1.42e-10 Ulcerative colitis; CESC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg21248554 chr2:27665150 KRTCAP3 -0.43 -8.78 -0.47 2e-16 Total body bone mineral density; CESC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg07507251 chr3:52567010 NT5DC2 0.33 5.69 0.33 3.36e-8 Bipolar disorder; CESC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg11764359 chr7:65958608 NA -0.91 -14.38 -0.66 4.81e-35 Aortic root size; CESC cis rs4727963 0.846 rs1554703 chr7:122702062 T/C cg03640110 chr7:122635026 TAS2R16 -0.37 -5.78 -0.33 2.04e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs8017423 0.967 rs11845329 chr14:90727749 C/T cg14092571 chr14:90743983 NA -0.55 -8.33 -0.46 4.46e-15 Mortality in heart failure; CESC cis rs919433 0.963 rs4850430 chr2:198182796 A/T cg03934865 chr2:198174659 NA -0.4 -5.45 -0.32 1.15e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs6912958 0.967 rs6905947 chr6:88161949 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.38 -6.31 -0.36 1.2e-9 Monocyte percentage of white cells; CESC cis rs8141529 0.778 rs7287806 chr22:29213011 G/A cg02153584 chr22:29168773 CCDC117 0.64 9.3 0.5 5.56e-18 Lymphocyte counts; CESC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.93 0.34 9.63e-9 Tonsillectomy; CESC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg07395648 chr5:131743802 NA 0.42 5.52 0.32 7.92e-8 Breast cancer; CESC cis rs1050631 0.563 rs685042 chr18:33743998 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.53 7.25 0.41 4.63e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs7592578 0.882 rs61117285 chr2:191468986 G/C cg27211696 chr2:191398769 TMEM194B -0.62 -5.67 -0.33 3.64e-8 Diastolic blood pressure; CESC cis rs6912958 0.781 rs9444504 chr6:88181046 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -5.1 -0.3 6.48e-7 Monocyte percentage of white cells; CESC trans rs11039798 0.588 rs10437592 chr11:48598859 G/T cg15704280 chr7:45808275 SEPT13 0.61 6.16 0.35 2.65e-9 Axial length; CESC cis rs7084402 0.967 rs1658493 chr10:60281090 C/T cg07615347 chr10:60278583 BICC1 -0.59 -9.44 -0.5 2.03e-18 Refractive error; CESC cis rs2857078 0.732 rs9893756 chr17:42321109 T/C cg13607699 chr17:42295918 UBTF -0.83 -11.82 -0.59 3.56e-26 Red cell distribution width;Reticulocyte count; CESC trans rs1973993 0.934 rs588660 chr1:96886604 G/A cg10631902 chr5:14652156 NA 0.54 7.47 0.42 1.16e-12 Weight; CESC cis rs4319547 0.956 rs10847179 chr12:123040985 T/C cg05707623 chr12:122985044 ZCCHC8 -0.59 -6.66 -0.38 1.57e-10 Body mass index; CESC cis rs11608355 0.545 rs11613021 chr12:109897998 T/G cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs6088580 0.609 rs6059845 chr20:33036500 G/A cg24642439 chr20:33292090 TP53INP2 0.51 6.75 0.38 9.47e-11 Glomerular filtration rate (creatinine); CESC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg02375832 chr11:62437615 C11orf48 -0.35 -5.21 -0.3 3.89e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7617773 1.000 rs7617773 chr3:48193515 C/T cg11946769 chr3:48343235 NME6 -0.68 -9.11 -0.49 2.01e-17 Coronary artery disease; CESC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg16325326 chr1:53192061 ZYG11B 0.9 15.51 0.69 4.6e-39 Monocyte count; CESC cis rs34779708 0.931 rs4934724 chr10:35393669 C/T cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.72e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs4566357 0.615 rs10174591 chr2:227913140 G/A cg11843606 chr2:227700838 RHBDD1 -0.5 -6.82 -0.39 6.08e-11 Coronary artery disease; CESC cis rs4237845 0.537 rs9645819 chr12:58270063 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.5 5.61 0.33 5.17e-8 Intelligence (multi-trait analysis); CESC cis rs2952156 0.876 rs903501 chr17:37839493 T/C cg20243544 chr17:37824526 PNMT 0.61 7.55 0.42 7.25e-13 Asthma; CESC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg23161317 chr6:28129485 ZNF389 0.52 6.46 0.37 5.08e-10 Depression; CESC cis rs2109514 1.000 rs6466579 chr7:116151155 T/C cg12739419 chr7:116140593 CAV2 -0.36 -6.54 -0.37 3.22e-10 Prevalent atrial fibrillation; CESC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg22535103 chr8:58192502 C8orf71 -0.94 -9.92 -0.52 6.46e-20 Developmental language disorder (linguistic errors); CESC cis rs1003719 0.788 rs9977314 chr21:38471963 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.62 0.47 6.19e-16 Eye color traits; CESC cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg10523679 chr1:76189770 ACADM 0.72 8.4 0.46 2.75e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1865721 0.682 rs3745082 chr18:73142734 G/T cg26385618 chr18:73139727 C18orf62 -0.48 -7.63 -0.42 4.28e-13 Intelligence; CESC cis rs7937682 0.883 rs517982 chr11:111462687 T/C cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC cis rs7045138 1 rs7045138 chr9:100591463 C/T cg13688889 chr9:100608707 NA -0.58 -9.03 -0.49 3.69e-17 Thyroid hormone levels; CESC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg24642844 chr7:1081250 C7orf50 -0.75 -9.03 -0.49 3.61e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7086627 0.515 rs10887903 chr10:82210641 C/T cg03267442 chr10:82210566 NA -0.34 -5.81 -0.34 1.82e-8 Post bronchodilator FEV1; CESC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg00310523 chr12:86230176 RASSF9 0.42 6.27 0.36 1.47e-9 Major depressive disorder; CESC cis rs7937682 0.814 rs1784788 chr11:111486136 T/G cg22437258 chr11:111473054 SIK2 0.71 9.4 0.5 2.72e-18 Primary sclerosing cholangitis; CESC cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg20891283 chr12:69753455 YEATS4 -0.76 -11.32 -0.57 1.71e-24 Blood protein levels; CESC cis rs17001868 0.568 rs909669 chr22:40742417 C/T cg07138101 chr22:40742427 ADSL 0.58 5.46 0.32 1.08e-7 Mammographic density (dense area); CESC cis rs735396 0.731 rs1182933 chr12:121454622 C/T cg02403541 chr12:121454288 C12orf43 0.74 10.2 0.53 7.97e-21 N-glycan levels; CESC cis rs1881797 1.000 rs1881796 chr1:247688931 G/A cg11166453 chr1:247681781 NA 0.44 5.8 0.34 1.87e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg01448562 chr3:133502909 NA -0.43 -5.91 -0.34 1.02e-8 Iron status biomarkers; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17546822 chr22:41865178 ACO2;PHF5A -0.4 -6.45 -0.37 5.29e-10 Gambling; CESC cis rs7044106 0.762 rs1158554 chr9:123400898 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 9.82 0.52 1.27e-19 Hip circumference adjusted for BMI; CESC trans rs10007810 0.760 rs7674730 chr4:41594636 G/T cg05088549 chr3:183978344 ECE2;CAMK2N2 -0.49 -6.05 -0.35 4.87e-9 Longevity (90 years and older); CESC cis rs10493773 0.928 rs12741600 chr1:86191172 A/C cg17807903 chr1:86174739 ZNHIT6 -0.43 -5.91 -0.34 1.07e-8 Urate levels in overweight individuals; CESC cis rs10791097 0.694 rs4264159 chr11:130755784 G/T cg12179176 chr11:130786555 SNX19 0.65 10.14 0.53 1.21e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2522056 0.808 rs1016988 chr5:131744574 T/C cg24060327 chr5:131705240 SLC22A5 0.67 7.44 0.42 1.37e-12 Lymphocyte counts;Fibrinogen; CESC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg08504905 chr19:54663436 LENG1 0.48 6.42 0.37 6.23e-10 Weight; CESC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26979279 chr8:99057120 RPL30 0.46 6.05 0.35 4.87e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4604732 0.631 rs76761880 chr1:247626377 T/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04020816 chr5:109025456 MAN2A1 0.57 6.4 0.37 6.84e-10 Gut microbiome composition (summer); CESC cis rs742614 0.533 rs736953 chr20:32415089 G/T cg06304546 chr20:32448765 NA -0.42 -5.38 -0.31 1.62e-7 Stearic acid (18:0) levels; CESC trans rs7943203 1.000 rs4754322 chr11:108311655 T/C cg24643211 chr18:11851603 GNAL;CHMP1B -0.47 -6.13 -0.35 3.12e-9 Red blood cell count;Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02501984 chr12:133263946 POLE;PXMP2 -0.4 -6.22 -0.36 1.96e-9 Gambling; CESC cis rs6545883 0.965 rs2305156 chr2:61729268 T/C cg15711740 chr2:61764176 XPO1 -0.42 -5.28 -0.31 2.66e-7 Tuberculosis; CESC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg17376030 chr22:41985996 PMM1 0.71 7.76 0.43 1.81e-13 Vitiligo; CESC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.41 6.86 0.39 4.85e-11 Personality dimensions; CESC cis rs7605827 0.836 rs13009246 chr2:15640237 A/G cg19274914 chr2:15703543 NA 0.36 6.4 0.37 6.84e-10 Educational attainment (years of education); CESC cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg05555928 chr11:63887634 MACROD1 0.55 8.19 0.45 1.15e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs1451375 0.617 rs9942686 chr7:50596381 G/A cg14593290 chr7:50529359 DDC 0.5 6.04 0.35 5.34e-9 Malaria; CESC cis rs9457247 1.000 rs376574 chr6:167389956 A/T cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC trans rs11098499 0.738 rs10026493 chr4:120384194 C/G cg25214090 chr10:38739885 LOC399744 0.69 9.79 0.52 1.58e-19 Corneal astigmatism; CESC cis rs6964587 1.000 rs411 chr7:91557758 C/G cg17063962 chr7:91808500 NA -0.58 -7.83 -0.43 1.15e-13 Breast cancer; CESC cis rs2859741 0.528 rs6686296 chr1:37489380 G/T cg09363841 chr1:37513479 NA 0.49 7.12 0.4 1.03e-11 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg04450456 chr4:17643702 FAM184B 0.36 5.21 0.3 3.81e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs71277158 0.688 rs6762609 chr3:169916919 A/G cg04067573 chr3:169899625 PHC3 -0.64 -6.39 -0.37 7.22e-10 Prostate cancer; CESC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg02569458 chr12:86230093 RASSF9 0.52 7.52 0.42 8.77e-13 Major depressive disorder; CESC cis rs7178572 0.568 rs28584877 chr15:77599003 C/A cg22256960 chr15:77711686 NA 0.53 6.37 0.36 8.52e-10 Type 2 diabetes; CESC cis rs9815354 0.597 rs59432762 chr3:41812294 G/C cg03022575 chr3:42003672 ULK4 0.7 6.17 0.35 2.5e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs629535 0.814 rs571682 chr8:70062793 A/G cg21567404 chr3:27674614 NA 0.82 9.72 0.51 2.63e-19 Dupuytren's disease; CESC cis rs80130819 0.636 rs2634690 chr12:48712638 C/T cg05342945 chr12:48394962 COL2A1 -0.47 -5.26 -0.31 2.92e-7 Prostate cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16452840 chr11:59383203 OSBP -0.52 -6.77 -0.38 8.45e-11 Asthma; CESC cis rs9828933 0.766 rs3774725 chr3:63974258 T/G cg16258503 chr3:63850278 ATXN7;THOC7 -0.82 -8.1 -0.45 2e-14 Type 2 diabetes; CESC cis rs9354308 1.000 rs9354308 chr6:66565353 A/G cg07460842 chr6:66804631 NA 0.49 6.05 0.35 4.83e-9 Metabolite levels; CESC cis rs8028182 0.636 rs62027181 chr15:75839952 A/G cg20655648 chr15:75932815 IMP3 0.48 6.0 0.35 6.42e-9 Sudden cardiac arrest; CESC cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg24920358 chr1:40204285 PPIE -0.4 -6.01 -0.35 6.09e-9 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14871650 chr4:170541668 CLCN3 0.74 8.25 0.45 7.34e-15 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs965513 1.000 rs7030280 chr9:100535267 C/T cg13688889 chr9:100608707 NA -0.59 -8.31 -0.45 5.05e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.82e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1707322 1.000 rs1768817 chr1:46514534 C/G cg05343316 chr1:45956843 TESK2 -0.44 -5.44 -0.32 1.2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7927592 0.956 rs10896348 chr11:68357368 T/C cg01657329 chr11:68192670 LRP5 -0.4 -5.11 -0.3 6.03e-7 Total body bone mineral density; CESC trans rs10463316 0.894 rs954339 chr5:150752161 C/A cg24389359 chr12:111284228 CCDC63 -0.35 -6.17 -0.35 2.52e-9 Metabolite levels (Pyroglutamine); CESC cis rs7666738 0.716 rs7656233 chr4:99079237 G/A cg17366294 chr4:99064904 C4orf37 0.55 7.46 0.42 1.21e-12 Colonoscopy-negative controls vs population controls; CESC cis rs6540559 0.543 rs664097 chr1:210422179 C/T cg22029157 chr1:209979665 IRF6 0.48 5.85 0.34 1.46e-8 Cleft lip with or without cleft palate; CESC trans rs17033621 0.549 rs6706779 chr2:107569609 G/T cg17982866 chr13:113637695 MCF2L -0.4 -6.0 -0.35 6.47e-9 Intelligence (multi-trait analysis); CESC cis rs2933343 0.700 rs789240 chr3:128630635 T/C cg24203234 chr3:128598194 ACAD9 0.39 5.25 0.31 3.19e-7 IgG glycosylation; CESC cis rs12477438 0.520 rs11123762 chr2:99727789 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.87 0.7 2.48e-40 Chronic sinus infection; CESC cis rs12200560 0.505 rs927271 chr6:97075910 T/G cg06623918 chr6:96969491 KIAA0776 0.41 5.29 0.31 2.6e-7 Coronary heart disease; CESC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg17949981 chr6:28129498 ZNF389 0.48 6.07 0.35 4.37e-9 Depression; CESC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg23172400 chr8:95962367 TP53INP1 -0.42 -8.03 -0.44 3.14e-14 Type 2 diabetes; CESC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg00802000 chr16:706648 WDR90 -0.4 -6.16 -0.35 2.71e-9 Height; CESC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg18876405 chr7:65276391 NA -0.58 -7.66 -0.43 3.57e-13 Aortic root size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22395299 chr21:47706029 MCM3AP;C21orf57 -0.55 -6.96 -0.39 2.69e-11 Ulcerative colitis; CESC cis rs910316 1.000 rs12589376 chr14:75561152 C/T cg08847533 chr14:75593920 NEK9 0.99 18.74 0.75 1.84e-50 Height; CESC cis rs3782089 1.000 rs11602375 chr11:65296540 C/T cg00206168 chr11:65308501 LTBP3 1.0 6.54 0.37 3.15e-10 Height; CESC cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg19193384 chr17:30244184 NA -0.68 -6.26 -0.36 1.53e-9 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.43e-21 Prudent dietary pattern; CESC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg20573242 chr4:122745356 CCNA2 0.62 7.64 0.42 3.94e-13 Type 2 diabetes; CESC cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg13628971 chr7:2884303 GNA12 0.4 5.33 0.31 2.08e-7 Height; CESC cis rs9902453 0.791 rs6505141 chr17:27998187 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.79 10.74 0.55 1.47e-22 Coffee consumption (cups per day); CESC cis rs9359856 0.564 rs56224741 chr6:90475231 C/T cg13799429 chr6:90582589 CASP8AP2 -0.61 -5.66 -0.33 3.93e-8 Bipolar disorder; CESC cis rs1707322 1.000 rs10890360 chr1:46338444 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7917772 0.582 rs10786696 chr10:104378134 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.39 5.41 0.32 1.43e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2479724 0.846 rs2254474 chr6:41843044 T/G cg08135965 chr6:41755394 TOMM6 0.41 5.5 0.32 9.15e-8 Menarche (age at onset); CESC cis rs818427 0.795 rs454968 chr5:112188456 T/C cg07820702 chr5:112228657 REEP5 0.43 5.42 0.32 1.33e-7 Total body bone mineral density; CESC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg24829409 chr8:58192753 C8orf71 -0.69 -7.52 -0.42 8.6e-13 Developmental language disorder (linguistic errors); CESC cis rs61935443 0.720 rs892493 chr12:95283943 T/C cg21533806 chr12:95267307 NA 0.6 7.4 0.41 1.82e-12 Schizophrenia; CESC cis rs3741151 1.000 rs79778136 chr11:73041339 T/C cg17517138 chr11:73019481 ARHGEF17 1.06 7.44 0.42 1.38e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs6963495 0.585 rs1706923 chr7:105221097 A/G cg19920283 chr7:105172520 RINT1 0.5 5.81 0.34 1.76e-8 Bipolar disorder (body mass index interaction); CESC cis rs9790314 0.905 rs6441370 chr3:160993754 C/T cg03342759 chr3:160939853 NMD3 -0.47 -6.2 -0.36 2.18e-9 Morning vs. evening chronotype; CESC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg13206674 chr6:150067644 NUP43 0.43 5.9 0.34 1.1e-8 Lung cancer; CESC cis rs2985684 0.779 rs12160 chr14:50091932 T/A cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.48 -5.66 -0.33 3.83e-8 Carotid intima media thickness; CESC cis rs4253772 0.744 rs1134224 chr22:46633371 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 6.78 0.38 7.94e-11 LDL cholesterol;Cholesterol, total; CESC cis rs1355223 0.872 rs7112608 chr11:34699269 G/T cg11058730 chr11:34937778 PDHX;APIP -0.45 -6.01 -0.35 5.99e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.55 7.31 0.41 3.08e-12 Lymphocyte counts; CESC cis rs6545883 0.894 rs10496092 chr2:61524679 C/T cg15711740 chr2:61764176 XPO1 0.39 5.08 0.3 7.29e-7 Tuberculosis; CESC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg22903471 chr2:27725779 GCKR -0.52 -7.37 -0.41 2.16e-12 Total body bone mineral density; CESC cis rs17376456 0.569 rs10076965 chr5:93094972 G/A cg25358565 chr5:93447407 FAM172A 0.67 7.16 0.4 7.97e-12 Diabetic retinopathy; CESC cis rs28489187 0.558 rs6576763 chr1:85859376 T/C cg16011679 chr1:85725395 C1orf52 -0.43 -5.21 -0.3 3.89e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs2901656 0.629 rs10752946 chr1:172376632 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.51 8.18 0.45 1.16e-14 Red cell distribution width;Platelet distribution width; CESC cis rs9611565 0.506 rs2024566 chr22:41697338 A/G cg17376030 chr22:41985996 PMM1 0.48 5.38 0.31 1.6e-7 Vitiligo; CESC cis rs3105593 1.000 rs3105590 chr15:50864145 A/G cg08437265 chr15:50716283 USP8 0.42 5.51 0.32 8.52e-8 QT interval; CESC cis rs9467711 0.517 rs16901784 chr6:26555433 C/A cg12826209 chr6:26865740 GUSBL1 0.6 5.7 0.33 3.27e-8 Autism spectrum disorder or schizophrenia; CESC cis rs921968 0.643 rs613539 chr2:219455967 G/T cg02176678 chr2:219576539 TTLL4 0.42 7.12 0.4 1.01e-11 Mean corpuscular hemoglobin concentration; CESC cis rs9303401 0.659 rs12150536 chr17:56640834 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.93 0.62 5.59e-30 Cognitive test performance; CESC cis rs11785400 1.000 rs4297023 chr8:143733307 C/A cg24634471 chr8:143751801 JRK 0.46 6.06 0.35 4.68e-9 Schizophrenia; CESC cis rs9303401 0.612 rs2526370 chr17:56487636 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.51 6.9 0.39 3.85e-11 Cognitive test performance; CESC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.55 0.42 7.15e-13 Bipolar disorder; CESC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg17372223 chr3:52568218 NT5DC2 0.42 6.42 0.37 6.33e-10 Bipolar disorder; CESC cis rs6800768 0.604 rs76298099 chr3:24155775 G/T cg10674438 chr3:24145617 LOC152024 -0.46 -6.04 -0.35 5.08e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg10494973 chr17:80897199 TBCD 0.49 5.71 0.33 3.04e-8 Breast cancer; CESC trans rs9929218 0.501 rs12448999 chr16:68815549 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.87 14.08 0.65 5.62e-34 Colorectal cancer; CESC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs10465746 0.905 rs34274953 chr1:84415011 G/A cg10977910 chr1:84465055 TTLL7 0.47 6.36 0.36 8.77e-10 Obesity-related traits; CESC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.45 0.54 1.29e-21 Prudent dietary pattern; CESC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.83 -9.25 -0.49 7.55e-18 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05843257 chr22:24951377 SNRPD3;C22orf13 -0.61 -7.03 -0.4 1.73e-11 Gut microbiome composition (summer); CESC cis rs5753618 0.583 rs5753615 chr22:31828027 T/C cg13145458 chr22:31556086 RNF185 -0.49 -5.86 -0.34 1.35e-8 Colorectal cancer; CESC cis rs1862626 0.506 rs7716644 chr5:56043426 C/T cg14703610 chr5:56206110 C5orf35 0.42 5.61 0.33 5.03e-8 Cancer (pleiotropy); CESC cis rs1670533 0.685 rs56019586 chr4:1059842 C/G cg27284194 chr4:1044797 NA 0.48 6.14 0.35 3.08e-9 Recombination rate (females); CESC cis rs933688 0.532 rs868557 chr5:90550379 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.44 -5.08 -0.3 7.22e-7 Smoking behavior; CESC trans rs61931739 0.517 rs9668303 chr12:34366701 C/T cg26384229 chr12:38710491 ALG10B 0.66 9.81 0.52 1.38e-19 Morning vs. evening chronotype; CESC cis rs4727963 0.740 rs12706479 chr7:122736336 G/A cg03640110 chr7:122635026 TAS2R16 0.4 6.2 0.36 2.14e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs10200850 0.656 rs13429815 chr2:240216070 T/C cg26975040 chr2:240205772 HDAC4 -0.58 -5.04 -0.3 8.44e-7 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs10463316 0.894 rs4099169 chr5:150766526 C/T cg03212797 chr5:150827313 SLC36A1 -0.45 -5.81 -0.34 1.74e-8 Metabolite levels (Pyroglutamine); CESC cis rs7599312 0.553 rs6710653 chr2:213404893 A/G cg16329650 chr2:213403929 ERBB4 0.59 8.57 0.47 8.74e-16 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09294055 chr16:3314419 NA -0.46 -6.09 -0.35 4.03e-9 Fibrinogen levels; CESC cis rs506597 0.764 rs221783 chr7:100292914 T/C cg10426581 chr7:100472382 SRRT -0.69 -5.39 -0.31 1.57e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg23758822 chr17:41437982 NA 1.05 16.03 0.7 6.73e-41 Menopause (age at onset); CESC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs870825 0.616 rs6844146 chr4:185636396 G/A cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg17949981 chr6:28129498 ZNF389 0.45 5.56 0.32 6.54e-8 Depression; CESC cis rs9457247 0.967 rs433191 chr6:167409662 T/A cg25258033 chr6:167368657 RNASET2 0.4 6.04 0.35 5.18e-9 Crohn's disease; CESC cis rs7917772 0.560 rs35095897 chr10:104377759 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.39 -5.23 -0.31 3.36e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg17376030 chr22:41985996 PMM1 -0.78 -8.33 -0.46 4.43e-15 Vitiligo; CESC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg06456125 chr7:65229604 NA 0.45 5.91 0.34 1.07e-8 Calcium levels; CESC cis rs36051895 0.530 rs2093447 chr9:5230374 G/T cg02405213 chr9:5042618 JAK2 -0.58 -6.61 -0.38 2.05e-10 Pediatric autoimmune diseases; CESC cis rs4692589 1.000 rs7666219 chr4:170932739 T/C cg19918862 chr4:170955249 NA 0.36 5.61 0.33 5.02e-8 Anxiety disorder; CESC cis rs6963495 0.818 rs55825845 chr7:105166713 A/G cg02135003 chr7:105160482 PUS7 -0.46 -5.51 -0.32 8.38e-8 Bipolar disorder (body mass index interaction); CESC cis rs9549260 0.564 rs8000965 chr13:41279488 C/T cg21288729 chr13:41239152 FOXO1 0.57 7.42 0.41 1.63e-12 Red blood cell count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10829727 chr17:73084309 SLC16A5 -0.39 -6.03 -0.35 5.45e-9 Gambling; CESC cis rs10089 0.953 rs1432615 chr5:127395371 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.15 0.53 1.14e-20 Ileal carcinoids; CESC cis rs7714584 1.000 rs11748158 chr5:150226345 C/T cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs7116495 1.000 rs679926 chr11:71769936 A/G cg26138937 chr11:71823887 C11orf51 0.85 7.24 0.41 4.87e-12 Severe influenza A (H1N1) infection; CESC cis rs12368653 0.591 rs1038914 chr12:58011066 G/A cg18357645 chr12:58087776 OS9 -0.37 -5.3 -0.31 2.39e-7 Multiple sclerosis; CESC cis rs10504229 0.679 rs60869047 chr8:58053221 G/A cg02725872 chr8:58115012 NA -0.33 -5.04 -0.3 8.84e-7 Developmental language disorder (linguistic errors); CESC cis rs1190552 0.846 rs4906212 chr14:102981595 A/G cg18135206 chr14:102964638 TECPR2 -0.44 -5.24 -0.31 3.22e-7 Blood protein levels; CESC cis rs9486719 0.947 rs11757102 chr6:96885073 G/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs2439831 0.867 rs16957630 chr15:43642780 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.85 12.05 0.59 6.08e-27 Lung cancer in ever smokers; CESC trans rs7246760 0.867 rs56307296 chr19:9744099 G/T cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs7568498 0.564 rs10490563 chr2:161914168 G/A cg22496339 chr2:162101262 NA -0.53 -5.63 -0.33 4.49e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs4555772 0.573 rs7714420 chr5:74340327 A/C cg03227963 chr5:74354835 NA 0.33 5.74 0.33 2.54e-8 Stearic acid (18:0) levels; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg12639324 chr10:92617735 HTR7 0.48 6.29 0.36 1.28e-9 Psoriatic arthritis; CESC cis rs8067545 0.586 rs57837691 chr17:20203073 T/C cg13482628 chr17:19912719 NA -0.42 -5.62 -0.33 4.73e-8 Schizophrenia; CESC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg00769240 chr8:12517080 NA -0.44 -6.02 -0.35 5.7e-9 Blood pressure (smoking interaction); CESC cis rs1008375 1.000 rs1008374 chr4:17683219 G/A cg16339924 chr4:17578868 LAP3 0.49 6.23 0.36 1.85e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12477438 0.798 rs6704766 chr2:99642818 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC trans rs163030 0.902 rs2560076 chr5:76736907 G/C cg26150533 chr8:82396069 FABP4 -0.39 -6.0 -0.35 6.5e-9 Caudate nucleus volume; CESC cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg24130564 chr14:104152367 KLC1 -0.49 -6.47 -0.37 4.74e-10 Reticulocyte count; CESC cis rs425277 1.000 rs262665 chr1:2083173 A/G cg16545954 chr1:2118288 C1orf86 0.33 5.6 0.33 5.35e-8 Height; CESC cis rs6740322 0.895 rs9309097 chr2:43554397 T/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -7.44 -0.42 1.45e-12 Coronary artery disease; CESC cis rs2439831 0.681 rs528517 chr15:43612925 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.91 11.19 0.57 4.78e-24 Lung cancer in ever smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05060602 chr4:183838922 DCTD -0.57 -6.26 -0.36 1.53e-9 Gut microbiome composition (summer); CESC cis rs1775715 0.737 rs2808078 chr10:32172552 C/T cg18675610 chr10:32216311 ARHGAP12 0.35 5.38 0.31 1.65e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1348850 0.914 rs4893944 chr2:178289357 G/T cg22681709 chr2:178499509 PDE11A -0.4 -5.9 -0.34 1.08e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs752010 0.714 rs6658500 chr1:42088344 A/G cg06885757 chr1:42089581 HIVEP3 -0.51 -8.82 -0.48 1.56e-16 Lupus nephritis in systemic lupus erythematosus; CESC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg02951883 chr7:2050386 MAD1L1 -0.45 -5.81 -0.34 1.78e-8 Bipolar disorder and schizophrenia; CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg18337363 chr3:52569053 NT5DC2 0.35 6.85 0.39 5.04e-11 Electroencephalogram traits; CESC cis rs7647973 1.000 rs1982861 chr3:49577665 A/G cg06212747 chr3:49208901 KLHDC8B 0.61 8.05 0.44 2.84e-14 Menarche (age at onset); CESC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg22508957 chr16:3507546 NAT15 0.73 8.99 0.48 4.92e-17 Tuberculosis; CESC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg17372223 chr3:52568218 NT5DC2 -0.39 -5.63 -0.33 4.51e-8 Bipolar disorder; CESC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg14159672 chr1:205819179 PM20D1 0.38 5.1 0.3 6.59e-7 Prostate-specific antigen levels; CESC cis rs10463316 0.928 rs10060441 chr5:150750006 A/G cg03212797 chr5:150827313 SLC36A1 -0.51 -6.63 -0.38 1.83e-10 Metabolite levels (Pyroglutamine); CESC cis rs9811920 0.599 rs1688758 chr3:99539890 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.58 -9.25 -0.49 7.99e-18 Axial length; CESC cis rs7647973 1.000 rs7613491 chr3:49508976 T/C cg07636037 chr3:49044803 WDR6 -0.7 -9.53 -0.51 1.06e-18 Menarche (age at onset); CESC cis rs9611565 0.559 rs5758397 chr22:42019251 C/T cg06481639 chr22:41940642 POLR3H 0.61 6.22 0.36 1.93e-9 Vitiligo; CESC cis rs11650494 0.908 rs73324323 chr17:47420054 G/T cg08112188 chr17:47440006 ZNF652 1.11 7.72 0.43 2.31e-13 Prostate cancer; CESC cis rs4566357 1.000 rs12612535 chr2:227926998 T/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.46 -0.32 1.1e-7 Coronary artery disease; CESC cis rs17376456 0.569 rs7702348 chr5:93065683 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.46 -5.21 -0.31 3.73e-7 Diabetic retinopathy; CESC cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg06212747 chr3:49208901 KLHDC8B 0.73 9.46 0.5 1.72e-18 Parkinson's disease; CESC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.67 9.57 0.51 8.08e-19 Menarche (age at onset); CESC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg12193833 chr17:30244370 NA 0.56 5.88 0.34 1.2e-8 Hip circumference adjusted for BMI; CESC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.49 0.46 1.54e-15 Menopause (age at onset); CESC cis rs6460942 0.915 rs62448620 chr7:12458170 C/T cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs7116495 0.609 rs2735787 chr11:71717873 T/C cg26138937 chr11:71823887 C11orf51 -1.27 -8.3 -0.45 5.44e-15 Severe influenza A (H1N1) infection; CESC cis rs12500824 0.534 rs2136854 chr4:77384592 A/G cg20311846 chr4:77356250 SHROOM3 -0.31 -5.73 -0.33 2.69e-8 Coronary artery disease; CESC trans rs10489896 0.541 rs6693478 chr1:234593403 T/C cg10395685 chr11:86085715 CCDC81 -0.43 -6.15 -0.35 2.9e-9 Cognitive test performance; CESC cis rs863345 0.604 rs950260 chr1:158491520 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC cis rs9443645 0.901 rs6937465 chr6:79570345 G/T cg05283184 chr6:79620031 NA -0.43 -6.76 -0.38 8.52e-11 Intelligence (multi-trait analysis); CESC cis rs763014 0.931 rs59476302 chr16:629006 C/T cg09263875 chr16:632152 PIGQ 0.65 10.88 0.56 4.93e-23 Height; CESC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 13.02 0.62 2.73e-30 Platelet count; CESC cis rs2797160 0.904 rs1612274 chr6:126014907 C/A cg05901451 chr6:126070800 HEY2 0.48 6.89 0.39 4.13e-11 Endometrial cancer; CESC trans rs526821 0.595 rs485555 chr11:55323570 A/G cg15704280 chr7:45808275 SEPT13 0.52 6.33 0.36 1.04e-9 Pediatric bone mineral density (spine); CESC cis rs6460942 0.915 rs62447639 chr7:12486803 T/C cg10578991 chr7:12443926 VWDE -0.49 -5.22 -0.31 3.59e-7 Coronary artery disease; CESC cis rs10504073 0.584 rs4873092 chr8:49974053 T/C cg00325661 chr8:49890786 NA 0.58 8.84 0.48 1.34e-16 Blood metabolite ratios; CESC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.45 -5.1 -0.3 6.46e-7 Breast cancer; CESC cis rs1509123 0.609 rs11078650 chr17:6704816 T/C cg12642237 chr17:6703447 TEKT1 -0.62 -5.08 -0.3 7.26e-7 Blood metabolite levels; CESC cis rs10463316 0.894 rs4246024 chr5:150740987 C/T cg03212797 chr5:150827313 SLC36A1 -0.48 -6.07 -0.35 4.52e-9 Metabolite levels (Pyroglutamine); CESC cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg18512352 chr11:47633146 NA -0.52 -7.37 -0.41 2.22e-12 Subjective well-being; CESC trans rs801193 0.935 rs2286683 chr7:66129843 G/A cg26939375 chr7:64535504 NA -0.64 -8.57 -0.47 8.53e-16 Aortic root size; CESC cis rs10242455 0.702 rs58348977 chr7:99188014 G/A cg25640893 chr7:99214727 ZNF498 0.69 5.21 0.3 3.84e-7 Blood metabolite levels; CESC cis rs2243480 0.764 rs2460423 chr7:65601216 A/T cg13147721 chr7:65941812 NA -0.98 -9.28 -0.5 6.25e-18 Diabetic kidney disease; CESC cis rs2573652 0.657 rs2573668 chr15:100541776 C/T cg09918751 chr15:100517450 ADAMTS17 0.33 5.94 0.34 8.97e-9 Height; CESC cis rs11792861 0.926 rs11787878 chr9:111866749 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.41 5.12 0.3 5.97e-7 Menarche (age at onset); CESC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.56 0.37 2.89e-10 Prudent dietary pattern; CESC cis rs79349575 0.783 rs62075852 chr17:47017176 T/C cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg19318889 chr4:1322082 MAEA -0.59 -7.21 -0.41 5.78e-12 Longevity; CESC cis rs447735 0.587 rs11647958 chr16:89720909 A/T cg04240660 chr16:89714849 CHMP1A -0.37 -5.41 -0.32 1.44e-7 Hemoglobin concentration; CESC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg11764359 chr7:65958608 NA -0.94 -14.21 -0.66 1.83e-34 Aortic root size; CESC trans rs3780486 0.846 rs3780490 chr9:33129839 A/G cg04842962 chr6:43655489 MRPS18A 1.01 19.68 0.77 9.13e-54 IgG glycosylation; CESC cis rs9308731 0.591 rs60982612 chr2:111940939 C/T cg04202892 chr2:111875749 ACOXL 0.41 5.8 0.34 1.88e-8 Chronic lymphocytic leukemia; CESC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg11663144 chr21:46675770 NA 0.61 9.61 0.51 5.9e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg22442454 chr1:209979470 IRF6 0.47 5.82 0.34 1.7e-8 Cleft lip with or without cleft palate; CESC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg09365446 chr1:150670422 GOLPH3L 0.4 5.26 0.31 3.03e-7 Melanoma; CESC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg18032046 chr6:28092343 ZSCAN16 -0.42 -5.33 -0.31 2.11e-7 Cardiac Troponin-T levels; CESC cis rs1808579 0.904 rs12457261 chr18:21146085 C/T cg14672496 chr18:21087552 C18orf8 0.38 5.72 0.33 2.87e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs6500395 0.962 rs1477135 chr16:48726823 C/T cg04672837 chr16:48644449 N4BP1 0.47 5.58 0.32 6.02e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7772486 0.790 rs2249386 chr6:146186611 G/A cg05347473 chr6:146136440 FBXO30 0.6 7.64 0.42 4.02e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.693 rs8080061 chr17:17776389 C/T cg16928487 chr17:17741425 SREBF1 0.59 10.63 0.55 3.2800000000000002e-22 Total body bone mineral density; CESC cis rs9303401 0.659 rs35103007 chr17:56900738 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.51 0.61 1.62e-28 Cognitive test performance; CESC cis rs4803455 0.565 rs11083616 chr19:41865643 A/G cg09537434 chr19:41945824 ATP5SL 0.67 9.22 0.49 9.38e-18 Migraine;Coronary artery disease; CESC cis rs4843747 0.671 rs28671027 chr16:88116323 G/A cg06915872 chr16:87998081 BANP 0.43 5.06 0.3 7.77e-7 Menopause (age at onset); CESC cis rs55794721 0.509 rs12027110 chr1:25775682 A/T cg03538708 chr1:25844672 NA -0.41 -6.18 -0.35 2.45e-9 Plateletcrit;Mean corpuscular volume; CESC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg26338869 chr17:61819248 STRADA 0.69 8.98 0.48 5.08e-17 Prudent dietary pattern; CESC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg23034840 chr1:205782522 SLC41A1 0.5 5.75 0.33 2.49e-8 Menarche (age at onset); CESC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg11247378 chr22:39784982 NA -0.64 -9.76 -0.51 1.96e-19 Intelligence (multi-trait analysis); CESC cis rs9287719 0.967 rs6721514 chr2:10751062 T/C cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs919433 0.889 rs788004 chr2:198219032 C/T cg20885578 chr2:198174922 NA 0.4 5.42 0.32 1.31e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg12963246 chr6:28129442 ZNF389 0.42 5.78 0.33 2.1e-8 Parkinson's disease; CESC cis rs2180341 0.960 rs7745944 chr6:127709574 A/G cg24812749 chr6:127587940 RNF146 1.03 14.49 0.66 2.01e-35 Breast cancer; CESC cis rs4588572 0.643 rs1035950 chr5:77785858 G/A cg11547950 chr5:77652471 NA -0.48 -6.11 -0.35 3.6e-9 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12903924 chr2:242448061 STK25 0.57 6.82 0.39 6.05e-11 Gut microbiome composition (summer); CESC cis rs735396 0.770 rs2257764 chr12:121446446 T/A cg02403541 chr12:121454288 C12orf43 -0.73 -10.13 -0.53 1.34e-20 N-glycan levels; CESC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg22903471 chr2:27725779 GCKR 0.5 6.9 0.39 3.75e-11 Total body bone mineral density; CESC cis rs11122272 0.701 rs2491402 chr1:231494338 T/C cg06096015 chr1:231504339 EGLN1 0.41 5.89 0.34 1.19e-8 Hemoglobin concentration; CESC cis rs4595586 1.000 rs4768388 chr12:39223924 G/A cg26384229 chr12:38710491 ALG10B -0.37 -5.14 -0.3 5.35e-7 Morning vs. evening chronotype; CESC cis rs1348850 0.632 rs11678875 chr2:178509068 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 7.46 0.42 1.24e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg14440974 chr22:39074834 NA 0.41 5.44 0.32 1.19e-7 Menopause (age at onset); CESC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 11.96 0.59 1.2e-26 Alzheimer's disease; CESC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.47 6.55 0.37 2.92e-10 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21408716 chr3:52279700 PPM1M 0.58 6.79 0.38 7.22e-11 Gut microbiome composition (summer); CESC cis rs3020736 0.500 rs6002605 chr22:42494335 A/G cg12850546 chr22:42539477 CYP2D7P1 0.43 5.16 0.3 4.96e-7 Autism spectrum disorder or schizophrenia; CESC cis rs6500395 1.000 rs2111243 chr16:48724897 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.37 -0.36 8.39e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6060717 0.536 rs6060666 chr20:34478954 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -6.93 -0.39 3.22e-11 Hip circumference adjusted for BMI; CESC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg16680214 chr1:154839983 KCNN3 -0.47 -7.52 -0.42 8.68e-13 Prostate cancer; CESC cis rs501120 1.000 rs554568 chr10:44755446 C/T cg09554077 chr10:44749378 NA 0.54 7.1 0.4 1.14e-11 Coronary artery disease;Coronary heart disease; CESC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg06074448 chr4:187884817 NA -0.37 -5.43 -0.32 1.27e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7072216 0.763 rs2147900 chr10:100174721 T/C cg26618903 chr10:100175079 PYROXD2 -0.38 -5.82 -0.34 1.66e-8 Metabolite levels; CESC cis rs9443189 0.950 rs6453845 chr6:76576527 G/T cg01950844 chr6:76311363 SENP6 -0.58 -6.13 -0.35 3.19e-9 Prostate cancer; CESC cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg00475322 chr7:917719 C7orf20 -0.45 -5.05 -0.3 8.27e-7 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05222119 chr17:80211999 CSNK1D -0.57 -6.1 -0.35 3.72e-9 Gut microbiome composition (summer); CESC cis rs881375 0.967 rs10739579 chr9:123694788 C/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.14 0.3 5.24e-7 Rheumatoid arthritis; CESC cis rs116988415 0.584 rs4902311 chr14:65241933 G/A cg25083366 chr14:65239357 SPTB 0.69 5.03 0.3 8.89e-7 Daytime sleep phenotypes; CESC cis rs12142240 0.698 rs1984490 chr1:46858734 C/T cg00530320 chr1:46809349 NSUN4 -0.59 -8.27 -0.45 6.45e-15 Menopause (age at onset); CESC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg02711726 chr17:80685570 FN3KRP -0.4 -5.29 -0.31 2.54e-7 Glycated hemoglobin levels; CESC cis rs7662987 1.000 rs7658118 chr4:99994608 C/T cg13256891 chr4:100009986 ADH5 -0.81 -6.09 -0.35 4.04e-9 Smoking initiation; CESC trans rs1814175 0.645 rs28627251 chr11:50048125 G/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.82 -0.76 9.27e-51 Height; CESC cis rs7481584 0.624 rs449466 chr11:3047603 C/T cg08508325 chr11:3079039 CARS 0.29 5.08 0.3 7.06e-7 Calcium levels; CESC cis rs28489187 0.683 rs67611930 chr1:85846592 A/G cg16011679 chr1:85725395 C1orf52 0.47 5.62 0.33 4.9e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4727027 0.901 rs6944781 chr7:148829566 A/G cg23158103 chr7:148848205 ZNF398 -0.4 -6.34 -0.36 9.68e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11872076 chr14:75744010 FOS 0.57 6.43 0.37 5.98e-10 Gut microbiome composition (summer); CESC cis rs12142240 0.698 rs13374893 chr1:46843800 A/G cg10495392 chr1:46806563 NSUN4 0.55 5.99 0.35 6.69e-9 Menopause (age at onset); CESC cis rs4835473 0.900 rs13123407 chr4:144879866 A/G cg25736465 chr4:144833511 NA 0.41 6.11 0.35 3.59e-9 Immature fraction of reticulocytes; CESC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg24549020 chr5:56110836 MAP3K1 -0.44 -5.28 -0.31 2.69e-7 Type 2 diabetes; CESC cis rs7584330 0.737 rs7595979 chr2:238364492 G/T cg14458575 chr2:238380390 NA 0.61 8.29 0.45 5.8e-15 Prostate cancer; CESC cis rs6938 0.618 rs12912839 chr15:75221245 C/T cg14664628 chr15:75095509 CSK -0.53 -6.91 -0.39 3.64e-11 Breast cancer; CESC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg22535103 chr8:58192502 C8orf71 -0.96 -9.81 -0.52 1.45e-19 Developmental language disorder (linguistic errors); CESC trans rs9393777 0.920 rs35869525 chr6:26946687 C/T cg06606381 chr12:133084897 FBRSL1 -1.01 -8.05 -0.44 2.76e-14 Intelligence (multi-trait analysis); CESC trans rs4843747 0.636 rs11117358 chr16:88105053 T/A cg26811252 chr16:29126840 RRN3P2 0.67 9.45 0.5 1.91e-18 Menopause (age at onset); CESC cis rs13242816 1.000 rs12669740 chr7:116138576 T/C cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC trans rs561341 1.000 rs1681718 chr17:30296445 G/A cg27661571 chr11:113659931 NA -0.83 -7.69 -0.43 2.82e-13 Hip circumference adjusted for BMI; CESC cis rs748404 0.697 rs505249 chr15:43559960 T/A cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.92 0.44 6.6e-14 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07780669 chr5:140018814 TMCO6 -0.68 -8.12 -0.45 1.72e-14 Gut microbiome composition (summer); CESC cis rs796364 1.000 rs281788 chr2:200783705 A/T cg23649088 chr2:200775458 C2orf69 0.56 5.26 0.31 3e-7 Schizophrenia; CESC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg00750074 chr16:89608354 SPG7 -0.42 -6.1 -0.35 3.68e-9 Multiple myeloma (IgH translocation); CESC cis rs10189230 0.967 rs12479119 chr2:222354213 C/T cg14652038 chr2:222343519 EPHA4 0.35 7.15 0.4 8.61e-12 Urate levels in lean individuals; CESC cis rs2204008 0.837 rs11181857 chr12:38413255 C/G cg26384229 chr12:38710491 ALG10B 0.64 9.71 0.51 2.81e-19 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25894045 chr1:226374346 ACBD3 0.55 6.05 0.35 4.8e-9 Gut microbiome composition (summer); CESC cis rs6964587 0.967 rs12535601 chr7:91718346 A/G cg17063962 chr7:91808500 NA 0.56 7.8 0.43 1.39e-13 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19198791 chr17:73975107 ACOX1;C17orf106 -0.52 -6.41 -0.37 6.67e-10 Ulcerative colitis; CESC cis rs2228479 0.850 rs62056061 chr16:89901767 G/A cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10799249 chr10:422187 DIP2C -0.64 -7.42 -0.41 1.64e-12 Gut microbiome composition (summer); CESC cis rs72945132 0.825 rs2298411 chr11:70206046 G/A cg00319359 chr11:70116639 PPFIA1 0.71 6.85 0.39 5.11e-11 Coronary artery disease; CESC cis rs667920 0.512 rs13069695 chr3:136291562 T/C cg15507776 chr3:136538369 TMEM22 -0.69 -5.37 -0.31 1.71e-7 Coronary artery disease; CESC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg05564831 chr3:52568323 NT5DC2 0.44 6.69 0.38 1.3e-10 Bipolar disorder; CESC trans rs3780486 0.801 rs56687083 chr9:33132134 A/G cg04842962 chr6:43655489 MRPS18A 1.01 19.64 0.77 1.24e-53 IgG glycosylation; CESC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03352830 chr11:487213 PTDSS2 0.67 6.55 0.37 3.02e-10 Body mass index; CESC cis rs6964587 0.773 rs2097810 chr7:91977226 G/A cg17063962 chr7:91808500 NA 0.55 7.07 0.4 1.36e-11 Breast cancer; CESC cis rs8014204 0.905 rs8014289 chr14:75377352 A/G cg11812906 chr14:75593930 NEK9 -0.45 -5.6 -0.33 5.49e-8 Caffeine consumption; CESC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg16006841 chr5:176797999 RGS14 -0.59 -6.32 -0.36 1.11e-9 Hemoglobin concentration;Hematocrit; CESC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg11843238 chr5:131593191 PDLIM4 0.36 5.21 0.3 3.82e-7 Breast cancer; CESC cis rs11679564 0.714 rs4389320 chr2:37172531 T/C cg14987922 chr2:37194071 STRN 0.4 5.07 0.3 7.53e-7 Immature fraction of reticulocytes; CESC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg19592336 chr6:28129416 ZNF389 0.47 6.51 0.37 3.74e-10 Cardiac Troponin-T levels; CESC cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg06212747 chr3:49208901 KLHDC8B 0.67 9.2 0.49 1.1e-17 Parkinson's disease; CESC cis rs6977660 0.507 rs72591448 chr7:19775298 C/T cg05791153 chr7:19748676 TWISTNB 0.76 6.96 0.39 2.66e-11 Thyroid stimulating hormone; CESC cis rs7772486 0.790 rs2247429 chr6:146217769 T/C cg05347473 chr6:146136440 FBXO30 0.57 7.31 0.41 3.07e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.76 10.62 0.55 3.45e-22 Prudent dietary pattern; CESC cis rs3768617 0.528 rs2027082 chr1:183084608 C/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.49e-35 Fuchs's corneal dystrophy; CESC cis rs796364 0.760 rs11690371 chr2:200989616 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.76 -6.52 -0.37 3.46e-10 Schizophrenia; CESC cis rs6866344 0.661 rs72812606 chr5:178129094 A/T cg03877680 chr5:178157825 ZNF354A 0.76 8.61 0.47 6.55e-16 Neutrophil percentage of white cells; CESC cis rs7044106 0.762 rs1158554 chr9:123400898 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.8 12.45 0.61 2.61e-28 Hip circumference adjusted for BMI; CESC cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.46 5.11 0.3 6.16e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs67311347 1.000 rs2887995 chr3:40409029 C/G cg24209194 chr3:40518798 ZNF619 0.45 5.92 0.34 9.94e-9 Renal cell carcinoma; CESC cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg20476274 chr7:133979776 SLC35B4 -0.53 -7.18 -0.4 7.18e-12 Mean platelet volume; CESC cis rs55788414 0.872 rs12102958 chr16:81186207 T/A cg06400318 chr16:81190750 PKD1L2 -0.58 -6.71 -0.38 1.2e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg20151795 chr6:28129481 ZNF389 0.44 5.57 0.32 6.17e-8 Depression; CESC cis rs9815354 0.627 rs73073268 chr3:42021403 C/A cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11759246 chr18:9615209 PPP4R1 0.46 6.25 0.36 1.65e-9 Systemic lupus erythematosus; CESC cis rs2228479 0.850 rs11645916 chr16:89835234 G/A cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03112782 chr1:37979729 MEAF6 0.48 6.21 0.36 2e-9 Systemic lupus erythematosus; CESC cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg25174290 chr11:3078921 CARS 0.55 7.37 0.41 2.19e-12 Longevity; CESC cis rs7044106 0.537 rs10818474 chr9:123489964 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.04 0.52 2.65e-20 Hip circumference adjusted for BMI; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13323912 chr4:48343649 SLAIN2 0.48 6.05 0.35 4.8e-9 Gut microbiota (bacterial taxa); CESC cis rs7914558 0.966 rs10883805 chr10:104708251 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.7 0.33 3.14e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs12599106 0.715 rs34006830 chr16:34878550 C/A cg26668828 chr6:292823 DUSP22 -0.72 -9.18 -0.49 1.32e-17 Menopause (age at onset); CESC cis rs909002 0.811 rs11575883 chr1:32085485 G/A cg13919466 chr1:32135498 COL16A1 -0.46 -8.15 -0.45 1.5e-14 Intelligence (multi-trait analysis); CESC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg03538708 chr1:25844672 NA -0.4 -6.01 -0.35 5.97e-9 Erythrocyte sedimentation rate; CESC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg13902645 chr11:5959945 NA 0.76 12.07 0.6 5.11e-27 DNA methylation (variation); CESC cis rs9815354 0.812 rs113528686 chr3:41951547 T/C cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.9e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs10788972 0.620 rs34764952 chr1:54483694 C/T cg25741118 chr1:54482237 LDLRAD1 -0.24 -5.7 -0.33 3.12e-8 Parkinson disease and lewy body pathology; CESC cis rs1707322 0.721 rs12069121 chr1:46231984 G/A cg05343316 chr1:45956843 TESK2 0.5 6.16 0.35 2.72e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg24250549 chr1:154909240 PMVK 0.64 8.98 0.48 5.24e-17 Prostate cancer; CESC cis rs684232 0.712 rs2955626 chr17:618100 C/G cg15660573 chr17:549704 VPS53 0.69 9.51 0.5 1.21e-18 Prostate cancer; CESC cis rs826838 1.000 rs11514441 chr12:38775190 C/T cg26384229 chr12:38710491 ALG10B 0.83 14.61 0.67 7.36e-36 Heart rate; CESC cis rs6466055 0.720 rs1204058 chr7:104958129 T/G cg04380332 chr7:105027541 SRPK2 0.42 5.4 0.31 1.49e-7 Schizophrenia; CESC cis rs9522267 0.535 rs9522290 chr13:112233130 A/G cg10483660 chr13:112241077 NA -0.33 -5.79 -0.33 2.04e-8 Hepatitis; CESC cis rs4132509 0.793 rs10803152 chr1:243846167 C/A cg21452805 chr1:244014465 NA 0.57 6.57 0.37 2.69e-10 RR interval (heart rate); CESC cis rs2985684 1.000 rs8014170 chr14:50071694 C/G cg02151108 chr14:50098012 C14orf104 -0.4 -5.23 -0.31 3.48e-7 Carotid intima media thickness; CESC cis rs10791097 0.678 rs10894272 chr11:130731081 A/G cg09137382 chr11:130731461 NA 0.39 5.99 0.35 6.95e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg12623088 chr15:66585521 DIS3L -0.46 -6.7 -0.38 1.26e-10 Vertical cup-disc ratio; CESC cis rs55728055 0.661 rs62237814 chr22:31992574 G/C cg01338084 chr22:32026380 PISD 1.26 8.55 0.47 9.7e-16 Age-related hearing impairment; CESC cis rs6674176 0.628 rs12145999 chr1:44428632 C/T cg12908607 chr1:44402522 ARTN -0.47 -6.74 -0.38 9.71e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7647973 1.000 rs3905330 chr3:49550774 A/G cg03060546 chr3:49711283 APEH 0.4 5.07 0.3 7.65e-7 Menarche (age at onset); CESC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg25405998 chr7:65216604 CCT6P1 0.45 5.11 0.3 6.14e-7 Aortic root size; CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 7.64 0.43 3.86e-13 Bipolar disorder; CESC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg01448562 chr3:133502909 NA -0.46 -6.44 -0.37 5.67e-10 Iron status biomarkers; CESC cis rs2281558 0.876 rs12625157 chr20:25345549 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.61 8.25 0.45 7.67e-15 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs287982 0.932 rs9973577 chr2:9960703 C/G cg10881225 chr2:9984929 TAF1B 0.43 5.37 0.31 1.72e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7582720 1.000 rs72926791 chr2:203822891 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg05340658 chr4:99064831 C4orf37 0.77 11.71 0.58 8.52e-26 Colonoscopy-negative controls vs population controls; CESC cis rs2075671 0.810 rs12531792 chr7:100280624 G/A cg20848291 chr7:100343083 ZAN -0.78 -9.91 -0.52 6.51e-20 Other erythrocyte phenotypes; CESC cis rs4689388 0.926 rs3821940 chr4:6286711 C/A cg00701064 chr4:6280414 WFS1 0.74 13.11 0.63 1.3e-30 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2380220 0.574 rs7766765 chr6:95997362 G/A cg15832292 chr6:96025679 MANEA 0.63 7.18 0.4 7.12e-12 Behavioural disinhibition (generation interaction); CESC cis rs6681460 0.966 rs4655650 chr1:67142286 A/G cg02459107 chr1:67143332 SGIP1 0.37 5.31 0.31 2.29e-7 Presence of antiphospholipid antibodies; CESC cis rs728616 0.764 rs117833443 chr10:81738136 A/C cg05935833 chr10:81318306 SFTPA2 -0.52 -5.06 -0.3 7.72e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9303401 0.659 rs35082010 chr17:56936867 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.45 0.61 2.57e-28 Cognitive test performance; CESC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg19622623 chr12:86230825 RASSF9 -0.48 -6.14 -0.35 3.05e-9 Major depressive disorder; CESC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.61 -0.55 3.8e-22 Alzheimer's disease; CESC cis rs7917772 0.582 rs10883744 chr10:104347247 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.64 0.33 4.41e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08732456 chr1:2020870 PRKCZ -0.52 -6.11 -0.35 3.62e-9 Gut microbiome composition (summer); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg03685910 chr17:39844834 EIF1 -0.51 -7.34 -0.41 2.58e-12 Height; CESC cis rs1801251 1.000 rs13013142 chr2:233600606 A/G cg25237894 chr2:233734115 C2orf82 0.45 7.82 0.43 1.27e-13 Coronary artery disease; CESC cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg20503657 chr10:835505 NA 0.77 7.65 0.43 3.68e-13 Eosinophil percentage of granulocytes; CESC cis rs2980439 0.556 rs2921059 chr8:8317887 G/T cg06636001 chr8:8085503 FLJ10661 0.54 7.25 0.41 4.6e-12 Neuroticism; CESC cis rs2235642 0.750 rs763152 chr16:1658056 T/C cg03771183 chr16:1608904 IFT140 0.4 5.91 0.34 1.04e-8 Coronary artery disease; CESC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg10053473 chr17:62856997 LRRC37A3 0.67 9.07 0.49 2.69e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg00166722 chr3:10149974 C3orf24 0.51 6.38 0.37 7.76e-10 Alzheimer's disease; CESC cis rs8180040 0.966 rs6787422 chr3:47418509 G/T cg27129171 chr3:47204927 SETD2 0.64 9.85 0.52 1.05e-19 Colorectal cancer; CESC trans rs13098911 0.598 rs71327003 chr3:46036521 C/T cg10236987 chr1:228114221 WNT9A 0.66 6.54 0.37 3.11e-10 Celiac disease; CESC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg13206674 chr6:150067644 NUP43 0.43 6.15 0.35 2.86e-9 Lung cancer; CESC cis rs1670533 1.000 rs6836350 chr4:1069973 C/T cg27284194 chr4:1044797 NA 0.46 5.99 0.35 6.7e-9 Recombination rate (females); CESC cis rs2228479 0.850 rs2238532 chr16:89863672 T/C cg06558623 chr16:89946397 TCF25 1.14 9.04 0.49 3.36e-17 Skin colour saturation; CESC cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg24110177 chr3:50126178 RBM5 0.5 6.75 0.38 9.48e-11 Intelligence (multi-trait analysis); CESC cis rs79407237 0.635 rs12631431 chr3:14755263 C/G cg09623510 chr3:14105751 TPRXL 0.54 5.09 0.3 6.79e-7 Sjögren's syndrome; CESC cis rs7927592 0.731 rs643609 chr11:68241833 A/G cg01657329 chr11:68192670 LRP5 -0.47 -6.23 -0.36 1.8e-9 Total body bone mineral density; CESC cis rs929596 0.563 rs1105879 chr2:234602202 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -5.34 -0.31 1.98e-7 Total bilirubin levels in HIV-1 infection; CESC cis rs17376456 0.757 rs10066431 chr5:93198204 A/G cg21475434 chr5:93447410 FAM172A 0.84 7.45 0.42 1.35e-12 Diabetic retinopathy; CESC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg27165867 chr14:105738592 BRF1 0.48 5.24 0.31 3.29e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7107174 1.000 rs10899468 chr11:78016650 C/T cg02023728 chr11:77925099 USP35 0.48 6.32 0.36 1.09e-9 Testicular germ cell tumor; CESC cis rs7635838 0.827 rs9848170 chr3:11495983 G/C cg00170343 chr3:11313890 ATG7 0.44 5.98 0.34 7.35e-9 HDL cholesterol; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg21515243 chr18:21033072 RIOK3 0.49 6.67 0.38 1.52e-10 Systemic lupus erythematosus; CESC cis rs1355223 0.583 rs2116085 chr11:34884001 C/A cg24088639 chr11:34937564 PDHX;APIP -0.41 -5.17 -0.3 4.72e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs1448094 0.511 rs11610371 chr12:86163487 A/G cg02569458 chr12:86230093 RASSF9 0.49 7.61 0.42 4.69e-13 Major depressive disorder; CESC cis rs1864400 0.696 rs2742239 chr10:43621712 A/G cg15436174 chr10:43711423 RASGEF1A -0.46 -5.4 -0.31 1.51e-7 Hirschsprung disease; CESC cis rs7714584 1.000 rs75774363 chr5:150223722 C/T cg22134413 chr5:150180641 NA 0.53 5.52 0.32 8.03e-8 Crohn's disease; CESC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg22029157 chr1:209979665 IRF6 0.66 9.48 0.5 1.54e-18 Cleft lip with or without cleft palate; CESC cis rs11608355 0.573 rs7970666 chr12:109793495 T/G cg19025524 chr12:109796872 NA -0.54 -7.96 -0.44 5.01e-14 Neuroticism; CESC cis rs8060686 0.545 rs10500543 chr16:68281311 T/C cg26727032 chr16:67993705 SLC12A4 -0.52 -5.6 -0.33 5.23e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs7086627 0.515 rs11202963 chr10:82210392 A/G cg00277334 chr10:82204260 NA -0.91 -15.99 -0.7 9.86e-41 Post bronchodilator FEV1; CESC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg24642844 chr7:1081250 C7orf50 -0.64 -8.35 -0.46 3.86e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9325144 0.600 rs11183505 chr12:38759110 G/T cg26384229 chr12:38710491 ALG10B -0.57 -7.91 -0.44 6.79e-14 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11887960 chr12:57824829 NA 0.59 6.44 0.37 5.51e-10 Gut microbiome composition (summer); CESC cis rs2295359 1.000 rs4655682 chr1:67610967 C/T cg03340356 chr1:67600835 NA 0.32 5.47 0.32 1.06e-7 Psoriasis; CESC cis rs1545257 0.514 rs2584940 chr2:24641639 A/C cg06627628 chr2:24431161 ITSN2 -0.47 -5.91 -0.34 1.05e-8 Sjögren's syndrome; CESC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -6.88 -0.39 4.39e-11 Bipolar disorder; CESC cis rs6674176 0.660 rs3791112 chr1:44379248 T/G cg12908607 chr1:44402522 ARTN -0.5 -7.52 -0.42 8.43e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 11.29 0.57 2.15e-24 Platelet count; CESC cis rs501120 0.925 rs1746050 chr10:44777188 C/A cg09554077 chr10:44749378 NA 0.53 5.91 0.34 1.05e-8 Coronary artery disease;Coronary heart disease; CESC cis rs4604732 0.536 rs4925674 chr1:247636906 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.4 5.45 0.32 1.15e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2404602 0.569 rs283793 chr15:76774752 G/A cg23625390 chr15:77176239 SCAPER 0.38 5.54 0.32 7.24e-8 Blood metabolite levels; CESC cis rs12586317 0.534 rs2273157 chr14:35438836 A/G cg16230307 chr14:35515116 FAM177A1 0.84 10.41 0.54 1.74e-21 Psoriasis; CESC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.17 -0.3 4.72e-7 Menopause (age at onset); CESC cis rs11190604 0.943 rs3750632 chr10:102279295 G/C cg07080220 chr10:102295463 HIF1AN 0.68 6.29 0.36 1.31e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg24531977 chr5:56204891 C5orf35 0.9 11.51 0.58 3.86e-25 Initial pursuit acceleration; CESC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg08109568 chr15:31115862 NA -0.7 -9.33 -0.5 4.49e-18 Huntington's disease progression; CESC cis rs4141404 0.851 rs8135417 chr22:31559255 G/A cg13145458 chr22:31556086 RNF185 0.54 6.52 0.37 3.56e-10 Paclitaxel-induced neuropathy; CESC cis rs7107174 1.000 rs11601161 chr11:78073280 A/G cg02023728 chr11:77925099 USP35 0.47 6.18 0.35 2.45e-9 Testicular germ cell tumor; CESC cis rs35160687 0.644 rs1863056 chr2:86491245 C/T cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.18 -0.3 4.46e-7 Night sleep phenotypes; CESC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg03806693 chr22:41940476 POLR3H 1.19 14.1 0.65 4.45e-34 Crohn's disease;Inflammatory bowel disease; CESC trans rs79976124 0.876 rs17511913 chr6:66644361 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 8.16 0.45 1.39e-14 Type 2 diabetes; CESC cis rs921968 0.612 rs2384950 chr2:219499719 T/C cg02176678 chr2:219576539 TTLL4 0.4 7.01 0.4 1.92e-11 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20682991 chr2:74981952 NA -0.66 -7.63 -0.42 4.32e-13 Gut microbiome composition (summer); CESC cis rs4689388 0.890 rs6446481 chr4:6295583 C/A cg25554036 chr4:6271136 WFS1 0.51 8.21 0.45 9.51e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15164871 chr12:123380523 VPS37B -0.45 -6.28 -0.36 1.38e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2731664 0.756 rs335433 chr5:176867207 T/C cg23176889 chr5:176863531 GRK6 -0.64 -10.94 -0.56 3.01e-23 Intelligence (multi-trait analysis); CESC cis rs8112211 1.000 rs56849284 chr19:38826947 T/C cg14299480 chr19:38876666 GGN -0.44 -5.95 -0.34 8.35e-9 Blood protein levels; CESC cis rs459571 0.959 rs2520099 chr9:136918139 T/C cg13789015 chr9:136890014 NCRNA00094 0.54 7.89 0.44 7.77e-14 Platelet distribution width; CESC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.51 -0.5 1.22e-18 Alzheimer's disease; CESC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg04772025 chr11:68637568 NA 0.5 6.13 0.35 3.13e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1538970 0.884 rs781232 chr1:45890399 C/T cg05343316 chr1:45956843 TESK2 -0.8 -11.33 -0.57 1.58e-24 Platelet count; CESC cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg09035930 chr12:129282057 SLC15A4 0.69 9.2 0.49 1.1e-17 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg03467027 chr4:99064603 C4orf37 0.43 5.28 0.31 2.66e-7 Colonoscopy-negative controls vs population controls; CESC cis rs67460515 0.563 rs1599375 chr3:160897771 C/T cg03342759 chr3:160939853 NMD3 0.55 7.2 0.4 6.08e-12 Parkinson's disease; CESC trans rs7672847 0.547 rs57526222 chr4:170483960 T/C cg19308436 chr1:237949471 RYR2 0.65 7.03 0.4 1.79e-11 Subjective well-being; CESC cis rs1707322 1.000 rs10890380 chr1:46449469 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.67 0.33 3.8e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs911555 0.723 rs7149767 chr14:103863545 G/A cg12935359 chr14:103987150 CKB 0.63 9.21 0.49 1.05e-17 Intelligence (multi-trait analysis); CESC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg05776053 chr2:74358815 NA 0.42 5.08 0.3 6.99e-7 Gestational age at birth (maternal effect); CESC cis rs1577917 0.666 rs6454471 chr6:86214456 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.57 7.77 0.43 1.76e-13 Response to antipsychotic treatment; CESC trans rs6137287 0.924 rs6047279 chr20:21142353 C/T cg18162120 chr1:224621880 WDR26 0.44 6.08 0.35 4.23e-9 Height; CESC cis rs6687430 0.526 rs12127400 chr1:10613660 C/T cg07384165 chr1:10488281 NA -0.48 -6.73 -0.38 1.04e-10 Hand grip strength; CESC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg17143192 chr8:8559678 CLDN23 0.73 8.76 0.47 2.39e-16 Obesity-related traits; CESC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg09509183 chr1:209979624 IRF6 -0.46 -5.63 -0.33 4.53e-8 Cleft lip with or without cleft palate; CESC cis rs4728302 0.838 rs10264922 chr7:133598975 A/G cg10665199 chr7:133106180 EXOC4 0.42 5.83 0.34 1.57e-8 Intelligence;Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16699022 chr16:89371566 ANKRD11 -0.57 -6.46 -0.37 4.95e-10 Gut microbiome composition (summer); CESC cis rs9549328 0.731 rs55804996 chr13:113625367 A/G cg22951483 chr13:113628068 MCF2L -0.34 -5.07 -0.3 7.41e-7 Systolic blood pressure; CESC cis rs1499614 1.000 rs1638731 chr7:66144679 C/T cg12463550 chr7:65579703 CRCP 0.77 6.04 0.35 5.23e-9 Gout; CESC cis rs796364 0.806 rs203769 chr2:200900866 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.81 -7.58 -0.42 5.82e-13 Schizophrenia; CESC trans rs10435719 0.764 rs10103485 chr8:11787563 C/T cg15556689 chr8:8085844 FLJ10661 0.52 6.47 0.37 4.6e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs524023 1.000 rs9734313 chr11:64358311 C/T cg07220939 chr11:64358617 SLC22A12 -0.35 -5.46 -0.32 1.09e-7 Urate levels in obese individuals; CESC cis rs9354308 0.866 rs2814095 chr6:66535706 C/G cg07460842 chr6:66804631 NA 0.58 6.6 0.38 2.28e-10 Metabolite levels; CESC cis rs3771570 0.901 rs73008106 chr2:242422446 C/T cg21155796 chr2:242212141 HDLBP 0.55 5.19 0.3 4.13e-7 Prostate cancer; CESC cis rs4819052 0.635 rs2838808 chr21:46621106 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.57 6.9 0.39 3.92e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg18490616 chr2:88469792 THNSL2 -0.52 -7.71 -0.43 2.48e-13 Response to metformin (IC50); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10078639 chr10:116286586 ABLIM1 -0.4 -6.24 -0.36 1.72e-9 Gambling; CESC cis rs2249694 0.810 rs2987785 chr10:135365003 C/T cg20169779 chr10:135381914 SYCE1 0.38 5.36 0.31 1.85e-7 Obesity-related traits; CESC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg14403583 chr14:105418241 AHNAK2 -0.57 -7.84 -0.43 1.14e-13 Rheumatoid arthritis; CESC cis rs7814319 0.966 rs6993518 chr8:97256341 T/A cg20787634 chr8:97240163 UQCRB -0.59 -7.82 -0.43 1.26e-13 Lung function (FVC); CESC cis rs66887589 0.775 rs6843229 chr4:120424087 T/C cg09307838 chr4:120376055 NA 0.53 7.12 0.4 9.9e-12 Diastolic blood pressure; CESC cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.41 5.81 0.34 1.83e-8 Schizophrenia; CESC cis rs2243480 0.803 rs160649 chr7:65543199 C/T cg13147721 chr7:65941812 NA -0.93 -8.86 -0.48 1.16e-16 Diabetic kidney disease; CESC cis rs7560272 0.501 rs12624267 chr2:73986931 C/T cg20560298 chr2:73613845 ALMS1 0.39 5.45 0.32 1.13e-7 Schizophrenia; CESC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg27170947 chr2:26402098 FAM59B 0.84 9.12 0.49 1.92e-17 Gut microbiome composition (summer); CESC cis rs6502050 0.835 rs12938965 chr17:80128646 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.61e-10 Life satisfaction; CESC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg18402987 chr7:1209562 NA 0.76 7.61 0.42 4.74e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg16545954 chr1:2118288 C1orf86 -0.33 -6.25 -0.36 1.65e-9 Height; CESC cis rs709400 0.832 rs10145755 chr14:104121984 C/T cg12935359 chr14:103987150 CKB -0.45 -6.08 -0.35 4.23e-9 Body mass index; CESC trans rs9929218 0.551 rs4783663 chr16:68720271 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.97 16.72 0.72 2.52e-43 Colorectal cancer; CESC cis rs3820928 0.935 rs12151597 chr2:227859224 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -5.45 -0.32 1.12e-7 Pulmonary function; CESC cis rs17854409 1.000 rs17854409 chr20:61491494 T/C cg05147244 chr20:61493195 TCFL5 0.92 6.02 0.35 5.91e-9 Obesity-related traits; CESC cis rs8070740 0.786 rs34856659 chr17:5327572 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.29 0.36 1.34e-9 Menopause (age at onset); CESC cis rs3741151 1.000 rs76610873 chr11:73084387 C/T cg17517138 chr11:73019481 ARHGEF17 0.93 6.32 0.36 1.1e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg23131131 chr22:24373011 LOC391322 -0.7 -9.7 -0.51 3.09e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3768617 0.510 rs12095664 chr1:183101686 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs3741151 0.892 rs2027761 chr11:73036179 C/T cg17517138 chr11:73019481 ARHGEF17 0.61 5.21 0.3 3.89e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs6500395 1.000 rs8044519 chr16:48669081 G/T cg04672837 chr16:48644449 N4BP1 0.53 6.74 0.38 9.91e-11 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.09 0.3 6.74e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.09 19.2 0.76 4.43e-52 Height; CESC cis rs2066819 1.000 rs117683816 chr12:56638267 T/C cg26714650 chr12:56694279 CS -1.42 -10.05 -0.53 2.39e-20 Psoriasis vulgaris; CESC cis rs2228479 0.717 rs1007932 chr16:89838541 C/T cg06558623 chr16:89946397 TCF25 0.88 7.89 0.44 7.98e-14 Skin colour saturation; CESC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg00908189 chr16:619842 PIGQ 0.64 9.15 0.49 1.62e-17 Height; CESC cis rs2243480 1.000 rs35058610 chr7:65390925 G/A cg12463550 chr7:65579703 CRCP 0.7 5.58 0.32 5.87e-8 Diabetic kidney disease; CESC cis rs2857078 0.654 rs9896789 chr17:42314567 C/T cg19774624 chr17:42201019 HDAC5 -0.47 -6.1 -0.35 3.65e-9 Red cell distribution width;Reticulocyte count; CESC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg07701084 chr6:150067640 NUP43 0.42 5.69 0.33 3.36e-8 Lung cancer; CESC cis rs4718428 0.705 rs13220977 chr7:66337648 A/T cg12165864 chr7:66369176 NA 0.55 6.22 0.36 1.92e-9 Corneal structure; CESC cis rs7917772 0.503 rs7068535 chr10:104349127 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.47 0.42 1.15e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs727505 0.607 rs67313231 chr7:124804532 T/A cg23710748 chr7:124431027 NA -0.37 -5.72 -0.33 2.94e-8 Lewy body disease; CESC cis rs589448 0.902 rs315134 chr12:69762713 G/A cg22834771 chr12:69754056 YEATS4 -0.57 -7.68 -0.43 3.15e-13 Cerebrospinal fluid biomarker levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26628795 chr2:111435723 BUB1 -0.43 -6.07 -0.35 4.42e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs61863818 0.709 rs10786343 chr10:99159465 C/A cg20016023 chr10:99160130 RRP12 -0.31 -5.33 -0.31 2.1e-7 Monocyte percentage of white cells; CESC cis rs10911232 0.507 rs4642853 chr1:182996242 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs11098499 0.863 rs2170276 chr4:120485824 A/C cg24375607 chr4:120327624 NA 0.45 5.51 0.32 8.55e-8 Corneal astigmatism; CESC cis rs11249608 0.636 rs6888567 chr5:178449074 C/T cg21905437 chr5:178450457 ZNF879 -0.61 -8.81 -0.48 1.63e-16 Pubertal anthropometrics; CESC cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.19 0.3 4.24e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg05255149 chr17:80675120 FN3KRP 0.47 5.15 0.3 5.1e-7 Glycated hemoglobin levels; CESC cis rs7107174 1.000 rs7128666 chr11:78102363 A/T cg02023728 chr11:77925099 USP35 0.47 6.3 0.36 1.24e-9 Testicular germ cell tumor; CESC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg18402987 chr7:1209562 NA 0.77 7.88 0.44 8.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10089 1.000 rs13357268 chr5:127423051 G/A cg19767477 chr5:127420684 SLC12A2 -0.42 -5.75 -0.33 2.51e-8 Ileal carcinoids; CESC cis rs1707322 0.752 rs28438704 chr1:46170544 G/A cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs34779708 0.966 rs4934538 chr10:35472150 T/C cg03585969 chr10:35415529 CREM 0.77 10.32 0.54 3.35e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4654899 0.802 rs4654724 chr1:21177210 C/T cg05370193 chr1:21551575 ECE1 0.4 5.64 0.33 4.34e-8 Superior frontal gyrus grey matter volume; CESC cis rs453301 0.571 rs2929453 chr8:9084341 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -6.95 -0.39 2.85e-11 Joint mobility (Beighton score); CESC cis rs11785400 0.793 rs35985277 chr8:143736137 C/T cg10596483 chr8:143751796 JRK 0.43 5.37 0.31 1.7e-7 Schizophrenia; CESC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg23985595 chr17:80112537 CCDC57 0.41 6.52 0.37 3.55e-10 Life satisfaction; CESC cis rs36051895 0.554 rs7856773 chr9:5204705 T/C cg02405213 chr9:5042618 JAK2 -0.49 -5.69 -0.33 3.41e-8 Pediatric autoimmune diseases; CESC cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg26769984 chr7:1090371 C7orf50 0.65 7.42 0.41 1.64e-12 Bronchopulmonary dysplasia; CESC cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg16447950 chr5:562315 NA -0.58 -6.06 -0.35 4.59e-9 Lung disease severity in cystic fibrosis; CESC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg07636037 chr3:49044803 WDR6 0.99 18.41 0.75 2.66e-49 Parkinson's disease; CESC cis rs6963495 0.818 rs6977748 chr7:105167462 T/G cg19920283 chr7:105172520 RINT1 0.7 6.35 0.36 9.44e-10 Bipolar disorder (body mass index interaction); CESC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg11764359 chr7:65958608 NA 0.67 8.65 0.47 5.08e-16 Calcium levels; CESC cis rs1801251 1.000 rs9653383 chr2:233670380 A/C cg08000102 chr2:233561755 GIGYF2 -0.68 -9.69 -0.51 3.29e-19 Coronary artery disease; CESC cis rs2637266 1.000 rs35991266 chr10:78378733 A/G cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC cis rs7727544 0.661 rs273900 chr5:131694606 G/A cg24060327 chr5:131705240 SLC22A5 -0.64 -8.53 -0.46 1.17e-15 Blood metabolite levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13370280 chr6:137539688 IFNGR1 0.46 6.19 0.36 2.24e-9 Gut microbiota (bacterial taxa); CESC cis rs9300255 0.699 rs11057204 chr12:123725827 T/C cg00376283 chr12:123451042 ABCB9 0.72 8.84 0.48 1.38e-16 Neutrophil percentage of white cells; CESC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 12.47 0.61 2.14e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg11752832 chr7:134001865 SLC35B4 0.52 6.76 0.38 8.81e-11 Mean platelet volume; CESC cis rs8114671 0.836 rs6141526 chr20:33615255 G/T cg24642439 chr20:33292090 TP53INP2 -0.46 -5.59 -0.32 5.53e-8 Height; CESC cis rs13336428 0.730 rs3946124 chr16:1525779 A/G cg26690334 chr16:1524521 CLCN7 0.35 5.15 0.3 5.19e-7 Bone mineral density; CESC cis rs2073300 0.609 rs74809795 chr20:23372383 A/C cg12062639 chr20:23401060 NAPB 1.07 8.85 0.48 1.29e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7520050 0.807 rs3013594 chr1:46138000 T/C cg06784218 chr1:46089804 CCDC17 0.31 5.37 0.31 1.74e-7 Red blood cell count;Reticulocyte count; CESC cis rs8141529 0.843 rs1065497 chr22:29279991 C/T cg15103426 chr22:29168792 CCDC117 0.61 7.74 0.43 2.08e-13 Lymphocyte counts; CESC cis rs3857536 0.704 rs4710570 chr6:66890244 A/G cg07460842 chr6:66804631 NA -0.41 -5.36 -0.31 1.82e-7 Blood trace element (Cu levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16973203 chr2:230876010 FBXO36 -0.51 -6.31 -0.36 1.14e-9 Gut microbiome composition (summer); CESC cis rs12477438 0.765 rs2167930 chr2:99592551 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.22 -0.53 6.79e-21 Chronic sinus infection; CESC cis rs5758659 0.652 rs133313 chr22:42401749 G/T cg04733989 chr22:42467013 NAGA 0.43 5.72 0.33 2.8e-8 Cognitive function; CESC cis rs2274273 0.905 rs2075601 chr14:55609234 C/T cg04306507 chr14:55594613 LGALS3 0.29 5.79 0.34 2e-8 Protein biomarker; CESC cis rs2302190 0.769 rs7218778 chr17:56664248 T/G cg25885038 chr17:56607967 SEPT4 -0.4 -5.43 -0.32 1.27e-7 Vitamin D levels; CESC cis rs826838 1.000 rs55828987 chr12:39056421 A/C cg26384229 chr12:38710491 ALG10B 0.81 13.7 0.64 1.14e-32 Heart rate; CESC cis rs2439831 0.867 rs3101443 chr15:43912372 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.82 8.62 0.47 6.32e-16 Lung cancer in ever smokers; CESC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg21782813 chr7:2030301 MAD1L1 0.42 5.93 0.34 9.37e-9 Bipolar disorder and schizophrenia; CESC cis rs425277 1.000 rs262667 chr1:2082722 T/C cg24578937 chr1:2090814 PRKCZ 0.55 9.56 0.51 8.69e-19 Height; CESC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg13880726 chr7:1868755 MAD1L1 0.54 7.39 0.41 1.95e-12 Bipolar disorder and schizophrenia; CESC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.49 0.5 1.42e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg22823121 chr1:150693482 HORMAD1 -0.4 -5.55 -0.32 6.9e-8 Melanoma; CESC cis rs3762637 0.941 rs112768052 chr3:122169384 G/A cg24169773 chr3:122142474 KPNA1 -0.53 -6.17 -0.35 2.56e-9 LDL cholesterol levels; CESC cis rs7605827 0.930 rs7579714 chr2:15686869 A/C cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs7100689 0.577 rs9285726 chr10:82035150 A/T cg00277334 chr10:82204260 NA -0.53 -6.64 -0.38 1.82e-10 Post bronchodilator FEV1; CESC cis rs258892 0.895 rs34302030 chr5:72059832 T/A cg21869765 chr5:72125136 TNPO1 -0.43 -5.35 -0.31 1.93e-7 Small cell lung carcinoma; CESC cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg08085267 chr17:45401833 C17orf57 -0.43 -5.41 -0.32 1.4e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6076065 0.548 rs1112818 chr20:23323936 G/A cg11657817 chr20:23433608 CST11 0.35 5.13 0.3 5.55e-7 Facial morphology (factor 15, philtrum width); CESC cis rs4664308 0.618 rs4665139 chr2:160890692 G/T cg03641300 chr2:160917029 PLA2R1 -0.59 -8.52 -0.46 1.24e-15 Idiopathic membranous nephropathy; CESC cis rs11690935 0.632 rs6737308 chr2:172872042 G/A cg13550731 chr2:172543902 DYNC1I2 0.45 6.27 0.36 1.44e-9 Schizophrenia; CESC cis rs11792861 0.926 rs77567374 chr9:111835034 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.41 5.1 0.3 6.34e-7 Menarche (age at onset); CESC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs4144743 0.759 rs4289057 chr17:45321030 G/A cg18085866 chr17:45331354 ITGB3 -0.65 -6.24 -0.36 1.77e-9 Body mass index; CESC cis rs11190604 1.000 rs2489034 chr10:102319192 C/T cg07080220 chr10:102295463 HIF1AN 0.62 5.9 0.34 1.1e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs1062177 1.000 rs2964585 chr5:151141895 C/T cg00977110 chr5:151150581 G3BP1 0.68 7.31 0.41 3.09e-12 Preschool internalizing problems; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08647641 chr7:91763896 CYP51A1 0.57 6.99 0.39 2.26e-11 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs138702 chr22:39132601 A/T cg14440974 chr22:39074834 NA 0.37 5.29 0.31 2.61e-7 Menopause (age at onset); CESC cis rs6893300 0.961 rs4700838 chr5:179185121 A/G cg14593053 chr5:179126677 CANX -0.52 -5.65 -0.33 4.07e-8 Resting heart rate; CESC cis rs933688 1.000 rs6866191 chr5:90746852 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 13.75 0.65 8.01e-33 Smoking behavior; CESC trans rs2415984 0.846 rs10137074 chr14:46850751 A/G cg14945696 chr3:52713679 PBRM1 -0.4 -6.19 -0.36 2.32e-9 Number of children ever born; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25003565 chr1:150207434 ANP32E -0.46 -6.12 -0.35 3.36e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs17412740 0.619 rs7820947 chr8:20461056 G/C cg04640250 chr12:72667526 LOC283392;TRHDE -0.7 -6.0 -0.35 6.52e-9 Preeclampsia; CESC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg07167872 chr1:205819463 PM20D1 -0.75 -12.59 -0.61 8.21e-29 Menarche (age at onset); CESC cis rs7216064 1.000 rs6504549 chr17:65888784 A/G cg07042672 chr17:66097459 LOC651250 -0.62 -7.45 -0.42 1.35e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6582630 0.555 rs56228141 chr12:38518652 T/G cg26384229 chr12:38710491 ALG10B 0.73 11.35 0.57 1.32e-24 Drug-induced liver injury (flucloxacillin); CESC cis rs4803468 1.000 rs11670757 chr19:41913431 G/T cg09537434 chr19:41945824 ATP5SL -1.03 -18.28 -0.75 7.53e-49 Height; CESC cis rs9300255 0.569 rs1727320 chr12:123700476 T/A cg00376283 chr12:123451042 ABCB9 0.7 8.83 0.48 1.45e-16 Neutrophil percentage of white cells; CESC cis rs317689 0.702 rs544696 chr12:69749939 T/C cg20891283 chr12:69753455 YEATS4 0.77 10.19 0.53 8.91e-21 Response to diuretic therapy; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06191203 chr2:152266755 RIF1 -0.52 -6.7 -0.38 1.25e-10 Ulcerative colitis; CESC cis rs1580019 0.587 rs7806113 chr7:32553084 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.98 0.76 2.51e-51 Cognitive ability; CESC cis rs897984 0.542 rs7197717 chr16:31083075 A/C cg02466173 chr16:30829666 NA -0.39 -6.77 -0.38 8.03e-11 Dementia with Lewy bodies; CESC cis rs12477438 1.000 rs1922624 chr2:99909958 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -8.12 -0.45 1.72e-14 Chronic sinus infection; CESC trans rs10506458 0.915 rs12426308 chr12:63405778 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.38 -18.17 -0.74 1.81e-48 Hemostatic factors and hematological phenotypes; CESC cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg26597838 chr10:835615 NA 0.86 8.89 0.48 9.97e-17 Eosinophil percentage of granulocytes; CESC cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg26061582 chr7:22766209 IL6 0.49 5.66 0.33 3.9e-8 Lung cancer; CESC cis rs1878931 0.520 rs12447807 chr16:3413896 A/G cg22508957 chr16:3507546 NAT15 -0.4 -5.81 -0.34 1.79e-8 Body mass index (adult); CESC cis rs7107174 1.000 rs2511169 chr11:77965321 T/C cg02023728 chr11:77925099 USP35 0.4 5.96 0.34 8.18e-9 Testicular germ cell tumor; CESC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg23708337 chr7:1209742 NA 0.55 5.47 0.32 1.04e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2011503 0.943 rs8102502 chr19:19652746 T/C cg03709012 chr19:19516395 GATAD2A 0.52 5.35 0.31 1.9e-7 Bipolar disorder; CESC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg13206674 chr6:150067644 NUP43 0.41 5.74 0.33 2.64e-8 Lung cancer; CESC cis rs6439153 0.933 rs7648877 chr3:128709980 T/C cg25356066 chr3:128598488 ACAD9 0.55 7.17 0.4 7.55e-12 Pneumococcal bacteremia; CESC cis rs8028182 0.636 rs28610581 chr15:75812474 A/G cg20655648 chr15:75932815 IMP3 0.48 5.89 0.34 1.14e-8 Sudden cardiac arrest; CESC cis rs75887402 0.744 rs17150337 chr5:122677252 G/A cg27033705 chr5:122759302 CEP120 0.92 6.11 0.35 3.51e-9 Breast cancer; CESC cis rs17209837 1.000 rs4148815 chr7:87087834 A/T cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC trans rs11098499 0.909 rs10026736 chr4:120384322 G/C cg25214090 chr10:38739885 LOC399744 0.7 9.73 0.51 2.45e-19 Corneal astigmatism; CESC trans rs9354308 0.933 rs2814134 chr6:66566658 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 7.96 0.44 5.21e-14 Metabolite levels; CESC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg12463550 chr7:65579703 CRCP 0.51 6.41 0.37 6.58e-10 Aortic root size; CESC cis rs9543976 1.000 rs73223968 chr13:76141721 C/A cg01531495 chr13:76123901 UCHL3 -0.55 -5.45 -0.32 1.14e-7 Diabetic retinopathy; CESC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg25072359 chr17:41440525 NA 0.51 6.62 0.38 1.95e-10 Menopause (age at onset); CESC cis rs72781680 1.000 rs72781667 chr2:24225667 A/G cg20701182 chr2:24300061 SF3B14 0.74 6.38 0.36 7.9e-10 Lymphocyte counts; CESC cis rs1707322 0.721 rs10789468 chr1:46124558 A/G cg03146154 chr1:46216737 IPP 0.77 10.98 0.56 2.37e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20364594 chr6:158981615 TMEM181 0.58 6.44 0.37 5.67e-10 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07194495 chr7:148958859 ZNF783 0.51 6.94 0.39 3.07e-11 Gut microbiota (bacterial taxa); CESC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg04772025 chr11:68637568 NA 0.5 6.13 0.35 3.13e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11792861 1.000 rs11792861 chr9:111809295 A/C cg13535736 chr9:111863775 C9orf5 -0.5 -6.61 -0.38 2.09e-10 Menarche (age at onset); CESC cis rs782590 0.902 rs4672052 chr2:55732018 A/C cg18811423 chr2:55921094 PNPT1 0.78 11.81 0.59 3.76e-26 Metabolic syndrome; CESC cis rs7130144 0.541 rs58761476 chr11:130463195 T/G cg26307797 chr11:130446613 NA -0.74 -6.5 -0.37 3.95e-10 Urate levels in lean individuals; CESC cis rs8067354 0.645 rs2645487 chr17:57886125 T/G cg13753209 chr17:57696993 CLTC 0.66 8.26 0.45 7.21e-15 Hemoglobin concentration; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19467356 chr22:41601070 L3MBTL2 0.45 6.31 0.36 1.18e-9 Systemic lupus erythematosus; CESC cis rs9858542 0.953 rs1873625 chr3:49666964 C/A cg07274523 chr3:49395745 GPX1 0.67 8.45 0.46 1.91e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs12545109 0.642 rs2055984 chr8:57418332 A/G cg09654669 chr8:57350985 NA -0.55 -6.51 -0.37 3.81e-10 Obesity-related traits; CESC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg17724175 chr1:150552817 MCL1 0.38 5.9 0.34 1.13e-8 Melanoma; CESC cis rs9300255 0.602 rs1716165 chr12:123648881 C/T cg05973401 chr12:123451056 ABCB9 0.5 5.81 0.34 1.79e-8 Neutrophil percentage of white cells; CESC cis rs1594829 0.553 rs1564577 chr8:26164723 G/A cg11498726 chr8:26250323 BNIP3L -0.4 -6.06 -0.35 4.68e-9 Height; CESC cis rs9902453 0.780 rs57037139 chr17:28173283 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.22 0.45 9.05e-15 Coffee consumption (cups per day); CESC cis rs72848980 0.512 rs56033495 chr10:105383611 G/A cg00126946 chr10:105363258 SH3PXD2A 0.6 8.48 0.46 1.62e-15 White matter hyperintensity burden; CESC cis rs10208940 0.920 rs13417100 chr2:68821725 C/T cg12452813 chr2:68675892 NA -0.52 -5.2 -0.3 4.01e-7 Urate levels in lean individuals; CESC trans rs74054849 0.850 rs56338141 chr1:16037825 T/C cg06826283 chr7:600452 PRKAR1B 0.7 6.17 0.35 2.56e-9 Alcoholic chronic pancreatitis; CESC cis rs6141600 0.540 rs761312 chr20:34687809 A/G cg07747181 chr20:34652970 NA -0.37 -5.17 -0.3 4.53e-7 Height;Hip circumference; CESC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 6.79 0.39 7.26e-11 Prudent dietary pattern; CESC cis rs9660992 0.710 rs1172111 chr1:205232980 C/T cg00857998 chr1:205179979 DSTYK 0.43 5.04 0.3 8.82e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs1847505 0.609 rs1514541 chr13:61586096 C/G cg25164009 chr13:61490935 NA -0.43 -6.18 -0.35 2.43e-9 Polychlorinated biphenyl levels; CESC cis rs826838 1.000 rs860400 chr12:39081279 A/G cg13010199 chr12:38710504 ALG10B -0.4 -5.36 -0.31 1.79e-7 Heart rate; CESC cis rs1707322 0.963 rs6666763 chr1:46436451 C/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6582630 0.502 rs11181210 chr12:38298069 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.23e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs116095464 0.558 rs28635197 chr5:279071 T/C cg20965017 chr5:231967 SDHA -0.46 -5.2 -0.3 4.02e-7 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04792727 chr1:231664260 TSNAX-DISC1;TSNAX -0.46 -6.48 -0.37 4.5e-10 Gut microbiota (bacterial taxa); CESC cis rs9787249 0.957 rs11206754 chr1:40216234 A/G cg02773041 chr1:40204384 PPIE 0.55 7.81 0.43 1.32e-13 Blood protein levels; CESC cis rs12618769 0.652 rs1139829 chr2:99225168 C/T cg10123293 chr2:99228465 UNC50 0.39 5.05 0.3 8.21e-7 Bipolar disorder; CESC cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg26116260 chr4:7069785 GRPEL1 -0.87 -12.39 -0.61 4.18e-28 Monocyte percentage of white cells; CESC cis rs4604732 0.631 rs7546720 chr1:247627229 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1355223 0.902 rs1361645 chr11:34746385 G/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.36 -0.36 8.66e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7666738 0.657 rs13102002 chr4:98617794 T/C cg05340658 chr4:99064831 C4orf37 0.51 5.09 0.3 6.65e-7 Colonoscopy-negative controls vs population controls; CESC cis rs5769765 1.000 rs738711 chr22:50282603 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.44 -5.76 -0.33 2.36e-8 Tonsillectomy; CESC cis rs9929218 0.954 rs17715762 chr16:68828250 T/G cg02972257 chr16:68554789 NA 0.44 5.25 0.31 3.09e-7 Colorectal cancer; CESC cis rs2273669 0.667 rs12195836 chr6:109357701 T/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs911555 0.755 rs8016676 chr14:103904842 C/A cg12935359 chr14:103987150 CKB 0.65 9.61 0.51 5.83e-19 Intelligence (multi-trait analysis); CESC cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg11752832 chr7:134001865 SLC35B4 0.51 6.42 0.37 6.21e-10 Mean platelet volume; CESC cis rs9911578 1.000 rs9897326 chr17:56902297 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis); CESC cis rs8018808 1.000 rs176767 chr14:77865614 A/G cg20045696 chr14:77926864 AHSA1 0.38 5.17 0.3 4.56e-7 Myeloid white cell count; CESC cis rs2072732 0.861 rs16823392 chr1:2953833 C/G cg03976712 chr1:2946727 NA 0.33 5.53 0.32 7.83e-8 Plateletcrit; CESC cis rs10463316 0.832 rs246484 chr5:150730938 T/C cg03212797 chr5:150827313 SLC36A1 -0.54 -6.95 -0.39 2.83e-11 Metabolite levels (Pyroglutamine); CESC cis rs11723261 0.582 rs6814287 chr4:122323 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.5 6.54 0.37 3.14e-10 Immune response to smallpox vaccine (IL-6); CESC cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg24308560 chr3:49941425 MST1R 0.61 9.04 0.49 3.43e-17 Intelligence (multi-trait analysis); CESC cis rs7666738 0.570 rs10032272 chr4:99095601 T/C cg17366294 chr4:99064904 C4orf37 0.47 6.1 0.35 3.84e-9 Colonoscopy-negative controls vs population controls; CESC cis rs79349575 0.783 rs318090 chr17:46991752 G/A cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs617791 0.678 rs551659 chr11:65749645 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 6.26 0.36 1.55e-9 Breast cancer; CESC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg00166722 chr3:10149974 C3orf24 0.48 6.13 0.35 3.09e-9 Alzheimer's disease; CESC cis rs10206020 0.885 rs11887527 chr2:1578080 A/G cg26248373 chr2:1572462 NA -0.61 -7.12 -0.4 9.87e-12 IgG glycosylation; CESC cis rs734999 0.505 rs60687045 chr1:2539603 G/A cg20673091 chr1:2541236 MMEL1 0.46 7.62 0.42 4.66e-13 Ulcerative colitis; CESC cis rs4727963 0.765 rs1525470 chr7:122733854 T/C cg03640110 chr7:122635026 TAS2R16 0.4 6.2 0.36 2.14e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC trans rs629535 0.911 rs688612 chr8:70011887 C/T cg21567404 chr3:27674614 NA -0.91 -10.9 -0.56 4.13e-23 Dupuytren's disease; CESC cis rs6502050 0.835 rs35555954 chr17:80122438 T/C cg23985595 chr17:80112537 CCDC57 -0.4 -6.44 -0.37 5.74e-10 Life satisfaction; CESC cis rs12137294 0.866 rs1172153 chr1:205220661 T/C cg21643547 chr1:205240462 TMCC2 -0.34 -5.46 -0.32 1.1e-7 Red cell distribution width; CESC cis rs4604732 0.631 rs12091081 chr1:247623064 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 6.04 0.35 5.29e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg02935154 chr7:12443704 VWDE -0.6 -6.82 -0.39 6.02e-11 Coronary artery disease; CESC cis rs2072732 0.808 rs55784203 chr1:2936754 G/T cg03976712 chr1:2946727 NA 0.33 5.15 0.3 5.01e-7 Plateletcrit; CESC cis rs8068544 0.606 rs77681389 chr17:40154419 T/C cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.94 -8.43 -0.46 2.27e-15 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs9649213 1.000 rs9649213 chr7:98021211 A/G cg24562669 chr7:97807699 LMTK2 -0.38 -5.24 -0.31 3.28e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg08526825 chr16:2802229 SRRM2;LOC100128788 0.52 6.16 0.35 2.68e-9 Psoriatic arthritis; CESC cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg09035930 chr12:129282057 SLC15A4 0.69 9.2 0.49 1.1e-17 Systemic lupus erythematosus; CESC cis rs1775715 0.835 rs113450267 chr10:32223728 G/A cg04359828 chr10:32216031 ARHGAP12 0.37 5.11 0.3 6.12e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs748404 0.560 rs1869258 chr15:43803621 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.49 7.29 0.41 3.47e-12 Lung cancer; CESC cis rs7605827 0.930 rs2052438 chr2:15701951 G/A cg19274914 chr2:15703543 NA 0.3 5.34 0.31 2.03e-7 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.19.702771R chr19:16673058 SLC35E1 -0.63 -7.52 -0.42 8.53e-13 Gut microbiome composition (summer); CESC cis rs10883723 0.810 rs2296585 chr10:104245549 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.39 0.41 1.93e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs6580649 0.943 rs1859444 chr12:48399403 T/C cg24011408 chr12:48396354 COL2A1 0.4 5.21 0.3 3.75e-7 Lung cancer; CESC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg24549020 chr5:56110836 MAP3K1 0.65 7.56 0.42 6.42e-13 Initial pursuit acceleration; CESC cis rs10489202 1.000 rs718885 chr1:167954659 A/G cg24449463 chr1:168025552 DCAF6 -0.46 -5.34 -0.31 2.02e-7 Schizophrenia; CESC cis rs11203032 1.000 rs11203030 chr10:90964286 A/G cg16672925 chr10:90967113 CH25H 0.74 7.21 0.4 5.94e-12 Heart failure; CESC cis rs9911578 1.000 rs9907499 chr17:56949044 A/G cg12560992 chr17:57184187 TRIM37 0.94 15.65 0.69 1.5e-39 Intelligence (multi-trait analysis); CESC cis rs34779708 0.931 rs34304999 chr10:35365705 C/T cg03585969 chr10:35415529 CREM 0.75 9.73 0.51 2.43e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs6942756 1.000 rs66864889 chr7:128952560 G/A cg02491457 chr7:128862824 NA -0.66 -8.86 -0.48 1.21e-16 White matter hyperintensity burden; CESC cis rs7826238 0.566 rs2945886 chr8:8148270 C/G cg15556689 chr8:8085844 FLJ10661 0.55 6.8 0.39 7.03e-11 Systolic blood pressure; CESC cis rs8068544 0.818 rs8079958 chr17:40155467 C/T cg26502583 chr17:39992600 KLHL10;NT5C3L -0.77 -6.21 -0.36 2.06e-9 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs9486719 1.000 rs12191653 chr6:96903898 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.45e-15 Migraine;Coronary artery disease; CESC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg20243544 chr17:37824526 PNMT 0.61 7.75 0.43 1.95e-13 Asthma; CESC cis rs1707322 0.721 rs4660314 chr1:46229885 T/C cg03146154 chr1:46216737 IPP 0.81 11.42 0.57 8.15e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg04317338 chr11:64019027 PLCB3 0.87 9.06 0.49 3.04e-17 Mean platelet volume; CESC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg04772025 chr11:68637568 NA 0.57 6.6 0.38 2.2e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs477692 0.789 rs506915 chr10:131398005 A/G cg05714579 chr10:131428358 MGMT 0.46 6.07 0.35 4.35e-9 Response to temozolomide; CESC cis rs2119480 0.731 rs453757 chr13:111303200 A/G cg16216153 chr13:111290848 CARKD -0.36 -5.51 -0.32 8.51e-8 Diastolic blood pressure; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11050116 chr8:17780536 PCM1 0.46 6.12 0.35 3.35e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9322193 0.566 rs4869767 chr6:150245110 A/G cg01145232 chr6:150245071 RAET1G -0.57 -7.19 -0.4 6.69e-12 Lung cancer; CESC cis rs2204008 0.550 rs11495600 chr12:38126654 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.99 -0.56 2.21e-23 Alzheimer's disease; CESC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg15352829 chr14:105391018 PLD4 -0.6 -10.55 -0.54 5.89e-22 Rheumatoid arthritis; CESC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 10.26 0.53 5.11e-21 Platelet count; CESC cis rs561341 1.000 rs501957 chr17:30314504 C/T cg00745463 chr17:30367425 LRRC37B -0.78 -7.16 -0.4 8.17e-12 Hip circumference adjusted for BMI; CESC cis rs6570726 0.935 rs449377 chr6:145852437 C/G cg23711669 chr6:146136114 FBXO30 0.8 12.27 0.6 1.05e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs911555 0.755 rs8014800 chr14:103946302 T/C cg24130564 chr14:104152367 KLC1 0.48 6.21 0.36 2.09e-9 Intelligence (multi-trait analysis); CESC cis rs2730245 0.563 rs2709857 chr7:158685257 T/C cg01943577 chr7:158741284 NA -0.45 -6.02 -0.35 5.64e-9 Height; CESC cis rs79349575 0.783 rs2112617 chr17:46977125 G/A cg16584676 chr17:46985605 UBE2Z 0.48 5.75 0.33 2.45e-8 Type 2 diabetes; CESC cis rs4561483 0.583 rs1029285 chr16:11987118 G/A cg08843971 chr16:11963173 GSPT1 0.46 6.47 0.37 4.65e-10 Testicular germ cell tumor; CESC cis rs9611565 0.694 rs202613 chr22:41821993 C/A cg06481639 chr22:41940642 POLR3H 0.64 6.41 0.37 6.73e-10 Vitiligo; CESC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg04772025 chr11:68637568 NA 0.53 6.32 0.36 1.08e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6459788 0.720 rs11768765 chr7:157253133 C/T cg06271696 chr7:157225062 NA -0.37 -5.21 -0.3 3.85e-7 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23194712 chr12:132401025 ULK1 -0.59 -6.35 -0.36 9.45e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10330885 chr16:88729968 MGC23284;MVD -0.64 -7.71 -0.43 2.47e-13 Gut microbiome composition (summer); CESC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg22535103 chr8:58192502 C8orf71 -1.03 -12.86 -0.62 9.66e-30 Developmental language disorder (linguistic errors); CESC cis rs2760061 0.598 rs605410 chr1:228116281 A/G cg01973587 chr1:228161476 NA 0.34 5.24 0.31 3.32e-7 Diastolic blood pressure; CESC cis rs1413885 0.526 rs9728544 chr1:65847105 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.47 6.15 0.35 2.8e-9 Anticoagulant levels; CESC cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg26597838 chr10:835615 NA 0.76 7.38 0.41 2.08e-12 Eosinophil percentage of granulocytes; CESC trans rs7395662 0.591 rs4882093 chr11:48530820 G/A cg00717180 chr2:96193071 NA -0.44 -6.06 -0.35 4.54e-9 HDL cholesterol; CESC cis rs9479482 1.000 rs5006620 chr6:150336665 C/T cg03788504 chr6:150331562 NA -0.4 -7.68 -0.43 3.09e-13 Alopecia areata; CESC cis rs2439831 0.717 rs10518820 chr15:43888976 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.73 7.78 0.43 1.58e-13 Lung cancer in ever smokers; CESC cis rs7909074 1.000 rs4948926 chr10:45392604 G/C cg05187965 chr10:45406764 TMEM72 -0.34 -5.29 -0.31 2.52e-7 Mean corpuscular volume; CESC cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg22875332 chr1:76189707 ACADM 0.61 6.21 0.36 2.03e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg23711669 chr6:146136114 FBXO30 -1.0 -15.56 -0.69 3.24e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.53 5.19 0.3 4.15e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8180040 0.764 rs13084117 chr3:47183239 C/A cg27129171 chr3:47204927 SETD2 0.69 10.44 0.54 1.33e-21 Colorectal cancer; CESC cis rs761746 0.577 rs131245 chr22:32126763 T/C cg25791279 chr22:32026902 PISD 0.47 5.03 0.3 9.05e-7 Intelligence; CESC cis rs1008375 0.898 rs10008445 chr4:17593978 G/T cg16339924 chr4:17578868 LAP3 0.73 9.5 0.5 1.31e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg23131131 chr22:24373011 LOC391322 -0.71 -10.14 -0.53 1.21e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7584330 0.518 rs74003106 chr2:238447004 A/G cg14458575 chr2:238380390 NA 0.67 6.29 0.36 1.3e-9 Prostate cancer; CESC cis rs9309473 0.950 rs13391258 chr2:73848933 C/T cg20560298 chr2:73613845 ALMS1 -0.45 -5.89 -0.34 1.17e-8 Metabolite levels; CESC cis rs7666738 0.830 rs7678250 chr4:98922109 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs3008870 1.000 rs4620509 chr1:67449941 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.18 -0.68 7.11e-38 Lymphocyte percentage of white cells; CESC cis rs9318086 0.935 rs9553083 chr13:24441525 C/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.38 -5.21 -0.3 3.84e-7 Myopia (pathological); CESC cis rs698813 0.555 rs7605771 chr2:44479778 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.33 0.31 2.11e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs4253772 0.575 rs9615364 chr22:46797503 G/A cg00784671 chr22:46762841 CELSR1 -0.49 -5.18 -0.3 4.42e-7 LDL cholesterol;Cholesterol, total; CESC cis rs10876993 0.928 rs1678540 chr12:58065002 A/G cg18357645 chr12:58087776 OS9 0.62 10.34 0.54 2.74e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs9611565 0.643 rs202634 chr22:41809623 A/G cg03806693 chr22:41940476 POLR3H 1.08 12.4 0.61 3.72e-28 Vitiligo; CESC cis rs2408955 0.501 rs8716 chr12:48539482 T/G cg04545296 chr12:48745243 ZNF641 0.35 6.1 0.35 3.65e-9 Glycated hemoglobin levels; CESC cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg09658497 chr7:2847517 GNA12 -0.38 -5.73 -0.33 2.75e-8 Height; CESC cis rs698813 0.674 rs6759891 chr2:44496005 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 5.63 0.33 4.6e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC trans rs7562732 0.546 rs17048092 chr2:119195525 C/T cg22678073 chr1:8087421 ERRFI1 -0.72 -6.1 -0.35 3.71e-9 Depression in response to interferon-based therapy in chronic hepatitis C; CESC cis rs6121246 0.520 rs6060425 chr20:30224355 C/T cg13852791 chr20:30311386 BCL2L1 0.69 6.84 0.39 5.36e-11 Mean corpuscular hemoglobin; CESC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg24675658 chr1:53192096 ZYG11B -0.6 -7.61 -0.42 4.78e-13 Monocyte count; CESC cis rs62458065 0.513 rs10268803 chr7:32547835 A/G cg20159608 chr7:32802032 NA -0.56 -6.23 -0.36 1.81e-9 Metabolite levels (HVA/MHPG ratio); CESC cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg05585544 chr11:47624801 NA -0.53 -8.11 -0.45 1.89e-14 Subjective well-being; CESC cis rs2486288 0.656 rs9921025 chr15:45546602 G/A cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.65 -0.38 1.71e-10 Glomerular filtration rate; CESC cis rs2251381 0.750 rs2255055 chr21:30537045 C/T cg24692254 chr21:30365293 RNF160 0.76 10.49 0.54 9.28e-22 Selective IgA deficiency; CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg24503407 chr1:205819492 PM20D1 -0.71 -12.03 -0.59 6.95e-27 Monocyte percentage of white cells; CESC cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.7 8.4 0.46 2.76e-15 Age-related macular degeneration (geographic atrophy); CESC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg05368731 chr17:41323189 NBR1 0.78 11.02 0.56 1.73e-23 Menopause (age at onset); CESC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs2439831 0.717 rs7165471 chr15:43644788 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.46 0.54 1.12e-21 Lung cancer in ever smokers; CESC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg11764359 chr7:65958608 NA 0.85 12.95 0.62 4.93e-30 Aortic root size; CESC cis rs329122 0.528 rs4559047 chr5:133848660 C/T cg26284174 chr5:133860141 NA 0.45 5.13 0.3 5.62e-7 Body mass index;Type 2 diabetes; CESC cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -5.88 -0.34 1.26e-8 Total body bone mineral density; CESC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg20151795 chr6:28129481 ZNF389 0.41 5.28 0.31 2.69e-7 Depression; CESC cis rs2559856 1.000 rs2695291 chr12:102087543 G/A cg15068132 chr12:102092402 CHPT1 -0.4 -5.32 -0.31 2.16e-7 Blood protein levels; CESC cis rs2408955 0.522 rs6580650 chr12:48418556 G/T cg04545296 chr12:48745243 ZNF641 -0.36 -6.07 -0.35 4.33e-9 Glycated hemoglobin levels; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg15112475 chr7:1198522 ZFAND2A -0.41 -6.45 -0.37 5.15e-10 Longevity;Endometriosis; CESC cis rs6502050 0.835 rs8074267 chr17:80158325 A/G cg23985595 chr17:80112537 CCDC57 -0.39 -6.24 -0.36 1.76e-9 Life satisfaction; CESC cis rs9584850 0.834 rs745638 chr13:99119307 C/G cg20750642 chr13:99100586 FARP1 0.4 6.08 0.35 4.28e-9 Neuroticism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10540759 chr22:19159404 NA -0.48 -6.14 -0.35 3.05e-9 Ulcerative colitis; CESC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg10351095 chr21:47802916 PCNT 0.46 6.35 0.36 9.48e-10 Testicular germ cell tumor; CESC cis rs751728 0.687 rs9357164 chr6:33761021 T/C cg25922239 chr6:33757077 LEMD2 0.44 6.07 0.35 4.33e-9 Crohn's disease; CESC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8141529 0.719 rs132561 chr22:29351179 C/T cg15103426 chr22:29168792 CCDC117 -0.59 -7.48 -0.42 1.07e-12 Lymphocyte counts; CESC cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg01579765 chr21:45077557 HSF2BP -0.57 -9.45 -0.5 1.85e-18 Mean corpuscular volume; CESC cis rs7208859 0.573 rs4055105 chr17:29102550 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17357984 chr19:532039 CDC34 -0.49 -6.11 -0.35 3.58e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9486719 1.000 rs12529248 chr6:96895377 T/G cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs9488822 0.676 rs13210143 chr6:116389636 G/A cg15226275 chr6:116381976 FRK 0.26 6.64 0.38 1.81e-10 Cholesterol, total;LDL cholesterol; CESC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg16680214 chr1:154839983 KCNN3 -0.45 -6.89 -0.39 3.95e-11 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13417256 chr12:32112244 C12orf35 0.57 6.02 0.35 5.85e-9 Gut microbiome composition (summer); CESC cis rs2228479 0.702 rs12600047 chr16:89831630 G/A cg00800038 chr16:89945340 TCF25 -0.93 -7.62 -0.42 4.61e-13 Skin colour saturation; CESC cis rs9916302 0.653 rs11657058 chr17:37699378 T/G cg00129232 chr17:37814104 STARD3 -0.55 -5.69 -0.33 3.39e-8 Glomerular filtration rate (creatinine); CESC cis rs10832963 1.000 rs11024739 chr11:18645843 A/C cg20219074 chr11:18656078 SPTY2D1 -0.81 -12.1 -0.6 3.87e-27 Breast cancer; CESC cis rs11098499 0.954 rs13145352 chr4:120409963 C/T cg09307838 chr4:120376055 NA -0.94 -12.7 -0.62 3.39e-29 Corneal astigmatism; CESC cis rs9513593 1.000 rs9300540 chr13:100018225 T/A cg21788972 chr13:99853209 UBAC2 0.6 6.82 0.39 6.27e-11 Psoriasis; CESC cis rs4243830 0.677 rs6693922 chr1:6584804 A/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.78 7.85 0.43 1.01e-13 Body mass index; CESC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -7.03 -0.4 1.8e-11 Extrinsic epigenetic age acceleration; CESC cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg18876405 chr7:65276391 NA 0.5 5.77 0.33 2.16e-8 Aortic root size; CESC cis rs4253772 0.530 rs9615933 chr22:46677298 G/A cg00784671 chr22:46762841 CELSR1 -0.57 -5.66 -0.33 4.01e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7520050 0.966 rs61783220 chr1:46335312 G/A cg24296786 chr1:45957014 TESK2 0.42 5.37 0.31 1.69e-7 Red blood cell count;Reticulocyte count; CESC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg16405210 chr4:1374714 KIAA1530 -0.48 -6.09 -0.35 3.96e-9 Obesity-related traits; CESC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.77 8.58 0.47 8.32e-16 Alzheimer's disease; CESC cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.24 0.45 7.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11190604 1.000 rs74210981 chr10:102287520 C/T cg07080220 chr10:102295463 HIF1AN 0.66 6.02 0.35 5.76e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs7301826 0.651 rs10744484 chr12:131298506 T/G cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC cis rs6580649 1.000 rs7305954 chr12:48403530 C/T cg05342945 chr12:48394962 COL2A1 -0.54 -6.81 -0.39 6.46e-11 Lung cancer; CESC cis rs9902453 0.904 rs4994353 chr17:28386280 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.65 -8.17 -0.45 1.27e-14 Coffee consumption (cups per day); CESC cis rs6456156 0.846 rs7774396 chr6:167519786 G/A cg23791538 chr6:167370224 RNASET2 -0.39 -5.06 -0.3 7.68e-7 Primary biliary cholangitis; CESC cis rs6545883 0.895 rs2177961 chr2:61560264 T/C cg15711740 chr2:61764176 XPO1 0.42 5.21 0.31 3.71e-7 Tuberculosis; CESC cis rs8027181 1.000 rs12900863 chr15:73094671 C/T cg25632853 chr15:73088954 NA 0.36 6.48 0.37 4.48e-10 Triglyceride levels; CESC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg00166722 chr3:10149974 C3orf24 0.5 6.37 0.36 8.41e-10 Alzheimer's disease; CESC cis rs113835537 0.529 rs78999944 chr11:66251228 C/G cg24851651 chr11:66362959 CCS 0.45 5.62 0.33 4.87e-8 Airway imaging phenotypes; CESC cis rs4728302 0.838 rs755664 chr7:133596671 C/G cg10665199 chr7:133106180 EXOC4 0.4 5.54 0.32 7.3e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7071206 0.947 rs4979902 chr10:79399946 C/T cg07817648 chr10:79422355 NA 0.91 11.91 0.59 1.72e-26 Bone mineral density; CESC cis rs9660992 0.547 rs748012 chr1:205216573 C/T cg21643547 chr1:205240462 TMCC2 -0.39 -5.37 -0.31 1.69e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs524023 0.957 rs552307 chr11:64357539 G/A cg07220939 chr11:64358617 SLC22A12 0.35 5.47 0.32 1.02e-7 Urate levels in obese individuals; CESC cis rs9910055 0.530 rs11656758 chr17:42301541 A/G cg08499158 chr17:42289980 UBTF -0.41 -5.25 -0.31 3.19e-7 Total body bone mineral density; CESC cis rs72781680 0.948 rs72781652 chr2:24213754 G/A cg08917208 chr2:24149416 ATAD2B 0.92 8.28 0.45 6.31e-15 Lymphocyte counts; CESC cis rs9916302 0.706 rs7208487 chr17:37543449 T/G cg07936489 chr17:37558343 FBXL20 0.9 9.82 0.52 1.27e-19 Glomerular filtration rate (creatinine); CESC cis rs1153858 0.945 rs1974981 chr15:45729123 C/T cg21132104 chr15:45694354 SPATA5L1 -0.75 -9.29 -0.5 5.93e-18 Homoarginine levels; CESC cis rs13253111 0.766 rs56232071 chr8:28063230 A/T cg26534493 chr8:28060551 NA 0.62 10.82 0.55 7.87e-23 Childhood body mass index; CESC cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9818758 0.607 rs13068038 chr3:49294250 C/A cg00383909 chr3:49044727 WDR6 0.8 6.15 0.35 2.8e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs3857536 0.776 rs1002764 chr6:66945760 C/A cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs1953600 0.668 rs7091565 chr10:81913561 A/G cg00277334 chr10:82204260 NA -0.4 -5.56 -0.32 6.69e-8 Sarcoidosis; CESC cis rs9611565 0.918 rs9538 chr22:41755857 G/T cg17376030 chr22:41985996 PMM1 0.63 6.68 0.38 1.36e-10 Vitiligo; CESC cis rs13242816 1.000 rs34295495 chr7:116068266 C/A cg04696780 chr7:116139425 CAV2 -0.63 -5.54 -0.32 7.28e-8 P wave duration; CESC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg08859206 chr1:53392774 SCP2 -0.68 -10.01 -0.52 3.33e-20 Monocyte count; CESC cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 8.79 0.47 1.99e-16 Hip circumference adjusted for BMI; CESC cis rs6714710 0.627 rs6748124 chr2:98519014 T/C cg26665480 chr2:98280029 ACTR1B 0.56 7.88 0.44 8.37e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg22800045 chr5:56110881 MAP3K1 0.8 9.9 0.52 7.3e-20 Initial pursuit acceleration; CESC trans rs7587026 0.806 rs62179390 chr2:166916817 C/T cg24507762 chr20:48099890 KCNB1 -0.37 -6.22 -0.36 1.88e-9 Mesial temporal lobe epilepsy with hippocampal sclerosis; CESC cis rs1215050 0.755 rs783958 chr4:98893836 A/T cg05340658 chr4:99064831 C4orf37 -0.52 -6.82 -0.39 6.23e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2235544 0.565 rs12758219 chr1:54466145 G/A cg25741118 chr1:54482237 LDLRAD1 0.24 5.8 0.34 1.91e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs10751667 0.580 rs11246363 chr11:971667 T/C cg20946044 chr11:1010712 AP2A2 -0.37 -5.11 -0.3 6.25e-7 Alzheimer's disease (late onset); CESC cis rs734999 0.588 rs4648652 chr1:2535758 A/G cg20673091 chr1:2541236 MMEL1 0.45 7.84 0.43 1.09e-13 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15090714 chr17:60142985 MED13 0.57 6.27 0.36 1.47e-9 Gut microbiome composition (summer); CESC cis rs1153858 1.000 rs1145085 chr15:45657804 A/G cg21132104 chr15:45694354 SPATA5L1 0.77 10.24 0.53 5.86e-21 Homoarginine levels; CESC cis rs7223966 1.000 rs8081612 chr17:61724695 A/G cg11494091 chr17:61959527 GH2 -0.38 -5.31 -0.31 2.36e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs11195062 0.521 rs4562740 chr10:111951930 C/A cg00817464 chr10:111662876 XPNPEP1 -0.52 -7.15 -0.4 8.49e-12 Multiple myeloma; CESC cis rs8072100 0.576 rs7216112 chr17:45406345 C/T cg25173405 chr17:45401733 C17orf57 0.5 6.17 0.35 2.57e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7216064 0.953 rs10445361 chr17:65962238 G/T cg07042672 chr17:66097459 LOC651250 0.56 6.5 0.37 4e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs3741151 0.881 rs73542929 chr11:73094539 G/T cg17517138 chr11:73019481 ARHGEF17 0.98 6.98 0.39 2.4e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs8044868 0.586 rs7188962 chr16:72098962 A/G cg01557791 chr16:72042693 DHODH -0.43 -5.89 -0.34 1.17e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs8072100 0.967 rs12452315 chr17:45479446 G/T cg08085267 chr17:45401833 C17orf57 0.51 6.84 0.39 5.43e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs877282 0.583 rs11253425 chr10:815173 G/A cg22713356 chr15:30763199 NA 1.01 9.05 0.49 3.08e-17 Uric acid levels; CESC cis rs9291683 0.530 rs4697698 chr4:9942577 C/T cg00071950 chr4:10020882 SLC2A9 0.77 14.18 0.66 2.49e-34 Bone mineral density; CESC cis rs6460942 0.915 rs6965564 chr7:12306013 C/T cg20607287 chr7:12443886 VWDE -0.43 -6.05 -0.35 5.03e-9 Coronary artery disease; CESC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg20243544 chr17:37824526 PNMT 0.48 5.96 0.34 8.16e-9 Glomerular filtration rate (creatinine); CESC cis rs7959452 0.605 rs12819406 chr12:69696400 G/T cg20891283 chr12:69753455 YEATS4 0.77 11.3 0.57 2.02e-24 Blood protein levels; CESC cis rs116095464 0.558 rs10462754 chr5:246669 T/C cg20965017 chr5:231967 SDHA -0.48 -5.4 -0.31 1.47e-7 Breast cancer; CESC cis rs959260 1.000 rs2033608 chr17:73367208 T/C cg20590849 chr17:73267439 MIF4GD -0.57 -6.51 -0.37 3.78e-10 Systemic lupus erythematosus; CESC cis rs3749237 0.595 rs10865955 chr3:49499829 G/A cg03060546 chr3:49711283 APEH 0.77 11.67 0.58 1.13e-25 Resting heart rate; CESC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.47 -0.37 4.71e-10 Total body bone mineral density; CESC cis rs11718455 0.960 rs4682712 chr3:43997971 T/C cg08738300 chr3:44038990 NA 0.46 6.01 0.35 6.02e-9 Coronary artery disease; CESC cis rs1729951 0.575 rs10935214 chr3:136693485 G/A cg04103450 chr3:136751342 NA 0.4 5.31 0.31 2.32e-7 Neuroticism; CESC cis rs2075371 0.830 rs1421478 chr7:133922793 T/A cg00033643 chr7:134001901 SLC35B4 0.41 5.28 0.31 2.74e-7 Mean platelet volume; CESC cis rs8067354 0.574 rs9789060 chr17:58018570 A/G cg13753209 chr17:57696993 CLTC 0.54 5.86 0.34 1.38e-8 Hemoglobin concentration; CESC cis rs8077889 0.956 rs4792910 chr17:41840229 T/C cg26893861 chr17:41843967 DUSP3 0.86 9.73 0.51 2.48e-19 Triglycerides; CESC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg19592336 chr6:28129416 ZNF389 0.6 8.08 0.44 2.36e-14 Depression; CESC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.63 5.32 0.31 2.26e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2625529 0.556 rs35603965 chr15:72523043 C/T cg16672083 chr15:72433130 SENP8 0.46 6.92 0.39 3.4e-11 Red blood cell count; CESC cis rs12497850 0.931 rs4974082 chr3:48999323 G/A cg07636037 chr3:49044803 WDR6 1.02 18.27 0.75 7.8199999999999992e-49 Parkinson's disease; CESC cis rs73019876 0.869 rs10410985 chr19:22147337 C/T cg11619707 chr19:22235551 ZNF257 -0.28 -5.19 -0.3 4.11e-7 Testicular germ cell tumor; CESC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.07 0.53 2.09e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg11764359 chr7:65958608 NA -0.7 -9.27 -0.49 6.71e-18 Aortic root size; CESC cis rs854765 0.964 rs12943202 chr17:17994332 T/A cg04398451 chr17:18023971 MYO15A 0.66 9.37 0.5 3.21e-18 Total body bone mineral density; CESC cis rs651907 0.535 rs1460097 chr3:101497569 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 6.03 0.35 5.44e-9 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16794665 chr9:111882389 C9orf5 -0.58 -6.47 -0.37 4.76e-10 Gut microbiome composition (summer); CESC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg16325326 chr1:53192061 ZYG11B 0.81 12.77 0.62 2.07e-29 Monocyte count; CESC cis rs2115630 0.875 rs8039472 chr15:85361644 A/G cg12501888 chr15:85177176 SCAND2 -0.45 -5.69 -0.33 3.33e-8 P wave terminal force; CESC trans rs61931739 0.534 rs4086956 chr12:34105047 A/T cg26384229 chr12:38710491 ALG10B 0.52 7.06 0.4 1.45e-11 Morning vs. evening chronotype; CESC cis rs9858542 0.953 rs11706370 chr3:49441091 G/A cg03060546 chr3:49711283 APEH -0.52 -5.96 -0.34 7.89e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg25036284 chr2:26402008 FAM59B 0.68 7.36 0.41 2.38e-12 Gut microbiome composition (summer); CESC trans rs11250098 0.503 rs7821826 chr8:10769439 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -6.72 -0.38 1.11e-10 Morning vs. evening chronotype; CESC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg18252515 chr7:66147081 NA 0.52 6.96 0.39 2.64e-11 Aortic root size; CESC cis rs637571 0.780 rs677029 chr11:65683531 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.42 5.21 0.3 3.82e-7 Eosinophil percentage of white cells; CESC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg00149659 chr3:10157352 C3orf10 0.69 8.2 0.45 1.02e-14 Alzheimer's disease; CESC cis rs4073582 0.595 rs555360 chr11:65960061 T/C cg14036092 chr11:66035641 RAB1B -0.53 -7.48 -0.42 1.06e-12 Gout; CESC cis rs3806843 0.897 rs2531338 chr5:140136957 A/T cg26395211 chr5:140044315 WDR55 0.39 5.17 0.3 4.51e-7 Depressive symptoms (multi-trait analysis); CESC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg08470875 chr2:26401718 FAM59B 0.75 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg24809958 chr1:6662478 KLHL21 0.5 6.66 0.38 1.57e-10 Systemic lupus erythematosus; CESC cis rs7208859 0.623 rs7208088 chr17:29143667 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7208859 0.673 rs56846352 chr17:29119188 C/T cg14008862 chr17:28927542 LRRC37B2 0.57 5.43 0.32 1.3e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs34779708 0.733 rs4391768 chr10:35547595 A/G cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09597195 chr6:116575322 TSPYL4 -0.58 -6.68 -0.38 1.39e-10 Gut microbiome composition (summer); CESC cis rs2274273 0.638 rs3759667 chr14:55658421 A/G cg04306507 chr14:55594613 LGALS3 0.31 5.33 0.31 2.14e-7 Protein biomarker; CESC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg23281280 chr6:28129359 ZNF389 0.51 6.65 0.38 1.63e-10 Depression; CESC cis rs2708240 1.000 rs2710096 chr7:147579836 T/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.36 -6.05 -0.35 4.82e-9 QT interval (drug interaction); CESC cis rs2439831 0.850 rs16965120 chr15:44100342 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.65 6.14 0.35 2.98e-9 Lung cancer in ever smokers; CESC cis rs1050631 1.000 rs1789514 chr18:33692654 T/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.44 5.73 0.33 2.74e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs67460515 0.563 rs16831981 chr3:160897780 T/C cg03342759 chr3:160939853 NMD3 -0.53 -6.9 -0.39 3.76e-11 Parkinson's disease; CESC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg24562669 chr7:97807699 LMTK2 0.54 7.93 0.44 6.35e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg22800045 chr5:56110881 MAP3K1 0.53 6.88 0.39 4.39e-11 Coronary artery disease; CESC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.82 0.48 1.53e-16 Bipolar disorder; CESC cis rs3859192 0.537 rs12309 chr17:38175462 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.62 9.17 0.49 1.33e-17 White blood cell count; CESC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg10691866 chr7:65817282 TPST1 -0.34 -5.47 -0.32 1.03e-7 Aortic root size; CESC cis rs11696501 0.688 rs4810465 chr20:44311354 A/G cg11783356 chr20:44313418 WFDC10B 0.31 5.03 0.3 9.22e-7 Brain structure; CESC cis rs10751667 0.666 rs7395182 chr11:927553 A/C cg06064525 chr11:970664 AP2A2 -0.52 -10.25 -0.53 5.74e-21 Alzheimer's disease (late onset); CESC cis rs459571 1.000 rs467387 chr9:136907005 G/A cg13789015 chr9:136890014 NCRNA00094 0.55 7.65 0.43 3.82e-13 Platelet distribution width; CESC trans rs12505749 1.000 rs12505749 chr4:57334112 C/G cg11734164 chr3:87101920 NA 0.95 6.21 0.36 2.01e-9 Airflow obstruction; CESC cis rs12142240 0.698 rs72677593 chr1:46824363 T/C cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs763014 0.833 rs3743903 chr16:632736 T/C cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg10319629 chr12:132285459 NA 0.47 6.84 0.39 5.43e-11 Migraine; CESC cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg24450063 chr1:156163899 SLC25A44 1.11 24.14 0.83 7.44e-69 Testicular germ cell tumor; CESC cis rs10875943 0.751 rs11168962 chr12:49672739 A/T cg14846292 chr12:49726500 C1QL4 -0.36 -5.05 -0.3 8.1e-7 Prostate cancer; CESC cis rs6543140 0.964 rs6543143 chr2:103085420 A/C cg04239558 chr2:103089729 SLC9A4 0.47 6.23 0.36 1.83e-9 Blood protein levels; CESC trans rs17685 0.712 rs28506984 chr7:75763484 A/G cg19862616 chr7:65841803 NCRNA00174 0.87 12.63 0.61 5.97e-29 Coffee consumption;Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07719547 chr12:9102628 M6PR 0.55 6.2 0.36 2.11e-9 Gut microbiome composition (summer); CESC cis rs9858542 0.953 rs9853683 chr3:49512588 A/G cg07274523 chr3:49395745 GPX1 0.66 8.05 0.44 2.78e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1595825 0.891 rs3851979 chr2:198707638 A/T cg00982548 chr2:198649783 BOLL 0.48 5.08 0.3 7.26e-7 Ulcerative colitis; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg19207856 chr21:38444952 PIGP;TTC3 -0.48 -6.16 -0.35 2.74e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg11764359 chr7:65958608 NA 0.68 8.79 0.48 1.9e-16 Aortic root size; CESC cis rs12900413 0.959 rs11632886 chr15:90322945 A/G cg24249390 chr15:90295951 MESP1 -0.4 -5.23 -0.31 3.38e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs8067545 0.611 rs11653630 chr17:20189046 C/T cg13482628 chr17:19912719 NA -0.42 -5.61 -0.33 5.2e-8 Schizophrenia; CESC cis rs9581857 0.615 rs9581849 chr13:28005782 G/T cg22138327 chr13:27999177 GTF3A 0.66 5.35 0.31 1.9e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7829975 0.540 rs2976909 chr8:8346690 C/T cg06636001 chr8:8085503 FLJ10661 -0.43 -5.33 -0.31 2.13e-7 Mood instability; CESC cis rs2730245 0.527 rs2527202 chr7:158738849 T/C cg24397884 chr7:158709396 WDR60 -0.92 -8.72 -0.47 3.05e-16 Height; CESC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg12463550 chr7:65579703 CRCP -0.5 -6.43 -0.37 5.9e-10 Aortic root size; CESC cis rs2180341 0.920 rs9398836 chr6:127576497 T/G cg27446573 chr6:127587934 RNF146 1.09 15.97 0.7 1.16e-40 Breast cancer; CESC cis rs7678296 0.649 rs77896458 chr4:37237843 A/G cg06805348 chr4:37245195 KIAA1239 0.53 5.79 0.33 2.04e-8 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg07507251 chr3:52567010 NT5DC2 0.4 7.1 0.4 1.15e-11 Intelligence (multi-trait analysis); CESC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg04287289 chr16:89883240 FANCA 0.9 15.28 0.68 3.23e-38 Vitiligo; CESC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg25036284 chr2:26402008 FAM59B -0.86 -9.4 -0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs6120849 0.754 rs6120804 chr20:33623701 C/A cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs1348850 0.513 rs6730406 chr2:178492722 C/T cg23306229 chr2:178417860 TTC30B 0.58 6.72 0.38 1.13e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg12288994 chr5:1860383 NA 0.41 6.85 0.39 5e-11 Cardiovascular disease risk factors; CESC cis rs11031096 0.711 rs10767881 chr11:4205122 C/G cg18678763 chr11:4115507 RRM1 -0.42 -5.57 -0.32 6.39e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7508 0.694 rs2410446 chr8:17923142 G/A cg18067069 chr8:17937731 ASAH1 -0.41 -5.43 -0.32 1.28e-7 Atrial fibrillation; CESC cis rs1712517 0.525 rs11191642 chr10:105055912 A/G cg04362960 chr10:104952993 NT5C2 -0.48 -5.67 -0.33 3.78e-8 Migraine; CESC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg08859206 chr1:53392774 SCP2 -0.62 -8.41 -0.46 2.57e-15 Monocyte count; CESC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg04267008 chr7:1944627 MAD1L1 -0.63 -8.2 -0.45 1.05e-14 Bipolar disorder and schizophrenia; CESC cis rs9768139 0.627 rs57920447 chr7:158121243 A/G cg27057461 chr7:158136379 PTPRN2 -0.33 -5.05 -0.3 8.15e-7 Calcium levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07516076 chr7:64197245 NA 0.45 6.22 0.36 1.97e-9 Fibrinogen levels; CESC cis rs7264396 0.779 rs2425162 chr20:34429974 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -10.31 -0.54 3.46e-21 Total cholesterol levels; CESC cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg19748678 chr4:122722346 EXOSC9 0.79 10.06 0.53 2.23e-20 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21422024 chr8:64080841 YTHDF3 0.68 8.44 0.46 2.11e-15 Gut microbiome composition (summer); CESC cis rs6570726 0.935 rs413916 chr6:145831400 T/C cg23711669 chr6:146136114 FBXO30 0.81 12.0 0.59 8.59e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs2637266 0.600 rs11001844 chr10:78405461 A/G cg18941641 chr10:78392320 NA 0.33 5.29 0.31 2.59e-7 Pulmonary function; CESC cis rs4654899 0.865 rs72973154 chr1:21459125 G/T cg05370193 chr1:21551575 ECE1 0.46 7.03 0.4 1.79e-11 Superior frontal gyrus grey matter volume; CESC cis rs7772486 0.817 rs2144477 chr6:146406248 C/T cg05347473 chr6:146136440 FBXO30 0.5 6.55 0.37 2.93e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs9467711 0.606 rs2073530 chr6:26375243 T/C cg06606381 chr12:133084897 FBRSL1 -0.77 -6.78 -0.38 7.69e-11 Autism spectrum disorder or schizophrenia; CESC cis rs372883 0.648 rs4817279 chr21:30638285 T/C cg08807101 chr21:30365312 RNF160 -0.46 -5.5 -0.32 9.14e-8 Pancreatic cancer; CESC cis rs4803468 1.000 rs3810174 chr19:41904165 C/T cg14132834 chr19:41945861 ATP5SL -0.61 -7.74 -0.43 2.09e-13 Height; CESC cis rs5758659 0.714 rs5758589 chr22:42518382 A/G cg00645731 chr22:42541494 CYP2D7P1 0.31 5.39 0.31 1.55e-7 Cognitive function; CESC cis rs6088580 0.634 rs6088483 chr20:32984714 T/A cg06115741 chr20:33292138 TP53INP2 -0.47 -6.03 -0.35 5.36e-9 Glomerular filtration rate (creatinine); CESC cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg05283184 chr6:79620031 NA -0.41 -6.38 -0.36 7.91e-10 Intelligence (multi-trait analysis); CESC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.0 10.3 0.53 3.82e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -6.3 -0.36 1.2e-9 Cardiac Troponin-T levels; CESC cis rs5769765 0.955 rs1321 chr22:50297435 A/G cg26441486 chr22:50317300 CRELD2 0.4 5.56 0.32 6.6e-8 Schizophrenia; CESC cis rs28374715 0.635 rs28557159 chr15:41657353 T/C cg20272979 chr15:41787780 ITPKA 0.39 5.29 0.31 2.54e-7 Ulcerative colitis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg01546243 chr14:61748019 TMEM30B 0.44 6.23 0.36 1.8e-9 Systemic lupus erythematosus; CESC cis rs1707322 0.717 rs2991988 chr1:46082431 C/A cg03146154 chr1:46216737 IPP -0.8 -11.01 -0.56 1.87e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs116095464 0.558 rs9312979 chr5:222057 A/C cg22857025 chr5:266934 NA -1.28 -14.18 -0.66 2.32e-34 Breast cancer; CESC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.4 0.32 1.45e-7 Major depressive disorder; CESC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg24549020 chr5:56110836 MAP3K1 -0.5 -6.23 -0.36 1.87e-9 Initial pursuit acceleration; CESC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg25072359 chr17:41440525 NA 0.49 6.42 0.37 6.13e-10 Menopause (age at onset); CESC cis rs7301826 0.610 rs7957899 chr12:131279076 T/C cg11011512 chr12:131303247 STX2 0.47 5.73 0.33 2.69e-8 Plasma plasminogen activator levels; CESC cis rs72781680 1.000 rs72788280 chr2:24095907 A/G cg08917208 chr2:24149416 ATAD2B 0.91 8.38 0.46 3.17e-15 Lymphocyte counts; CESC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg25072359 chr17:41440525 NA 0.48 6.57 0.37 2.63e-10 Menopause (age at onset); CESC cis rs11229030 0.893 rs2584859 chr11:57207447 A/G cg00522883 chr11:57194120 SLC43A3 0.45 5.96 0.34 7.85e-9 Crohn's disease; CESC cis rs2777491 0.915 rs7180418 chr15:41629502 A/C cg02330683 chr15:41787940 ITPKA 0.43 6.27 0.36 1.43e-9 Ulcerative colitis; CESC cis rs10927875 0.894 rs10927878 chr1:16319957 C/T cg22431228 chr1:16359049 CLCNKA 0.35 5.76 0.33 2.38e-8 Dilated cardiomyopathy; CESC trans rs1814175 0.646 rs61904497 chr11:49883449 A/T cg15704280 chr7:45808275 SEPT13 -1.0 -18.65 -0.75 3.79e-50 Height; CESC cis rs1322639 0.614 rs6940913 chr6:169563666 G/A cg03254818 chr6:169586852 NA 0.5 5.45 0.32 1.14e-7 Pulse pressure; CESC cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg00031303 chr3:195681400 NA 0.45 5.65 0.33 4.21e-8 Pancreatic cancer; CESC cis rs7267979 0.966 rs2227892 chr20:25264814 T/C cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg16339924 chr4:17578868 LAP3 0.63 8.03 0.44 3.2e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg00934597 chr7:893267 UNC84A 0.51 5.16 0.3 4.79e-7 Cerebrospinal P-tau181p levels; CESC cis rs863345 0.967 rs10797027 chr1:158523232 T/C cg12129480 chr1:158549410 OR10X1 -0.33 -6.63 -0.38 1.83e-10 Pneumococcal bacteremia; CESC trans rs2207136 0.835 rs569384 chr6:50913724 C/G cg06522515 chr3:184090630 THPO -0.36 -6.12 -0.35 3.3e-9 Myopia; CESC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg14393609 chr7:65229607 NA -0.45 -6.02 -0.35 5.91e-9 Aortic root size; CESC cis rs6430585 0.941 rs6708957 chr2:136520043 C/T cg07169764 chr2:136633963 MCM6 0.97 12.15 0.6 2.59e-27 Corneal structure; CESC cis rs56399783 0.901 rs17132744 chr7:2874982 T/C cg19731401 chr7:2775893 GNA12 0.58 5.25 0.31 3.12e-7 Childhood ear infection; CESC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg24250549 chr1:154909240 PMVK 0.59 7.83 0.43 1.19e-13 Prostate cancer; CESC cis rs2439831 0.850 rs7179388 chr15:44123945 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.66 5.66 0.33 3.88e-8 Lung cancer in ever smokers; CESC cis rs2370759 1.000 rs16933225 chr10:32599464 C/T cg01819863 chr10:32635814 EPC1 1.14 13.72 0.64 9.55e-33 Sexual dysfunction (female); CESC cis rs735396 1.000 rs1169309 chr12:121439192 G/T cg25281562 chr12:121454272 C12orf43 0.39 5.09 0.3 6.93e-7 N-glycan levels; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg11965913 chr1:205819406 PM20D1 0.95 17.45 0.73 6.39e-46 Menarche (age at onset); CESC cis rs7542091 0.739 rs10863793 chr1:210037420 G/A cg21951975 chr1:209979733 IRF6 0.43 7.06 0.4 1.49e-11 Monobrow; CESC cis rs4728302 0.869 rs10954434 chr7:133597864 A/G cg10665199 chr7:133106180 EXOC4 0.42 5.83 0.34 1.57e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg20503657 chr10:835505 NA 0.69 6.31 0.36 1.19e-9 Eosinophil percentage of granulocytes; CESC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg23590916 chr17:43697445 MGC57346 0.63 6.6 0.38 2.28e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg24130564 chr14:104152367 KLC1 -0.49 -6.46 -0.37 4.98e-10 Reticulocyte count; CESC cis rs2637266 1.000 rs2637266 chr10:78331318 C/T cg18941641 chr10:78392320 NA -0.3 -5.64 -0.33 4.36e-8 Pulmonary function; CESC cis rs11690935 1.000 rs2138348 chr2:172558172 A/C cg13550731 chr2:172543902 DYNC1I2 0.94 14.12 0.66 4.02e-34 Schizophrenia; CESC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg23048001 chr7:2026167 MAD1L1 0.39 5.16 0.3 4.87e-7 Bipolar disorder and schizophrenia; CESC cis rs2425143 0.908 rs6060605 chr20:34378132 T/G cg23207816 chr20:34252616 CPNE1;RBM12 0.67 5.67 0.33 3.81e-8 Blood protein levels; CESC cis rs854765 0.547 rs12150369 chr17:17911014 G/A cg16928487 chr17:17741425 SREBF1 -0.58 -10.22 -0.53 6.92e-21 Total body bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09325174 chr14:50154983 POLE2 -0.47 -6.44 -0.37 5.66e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs151234 0.676 rs151320 chr16:28568678 A/G cg01378222 chr16:28622494 SULT1A1 0.56 7.13 0.4 9.54e-12 Platelet distribution width; CESC cis rs317689 0.690 rs547827 chr12:69669703 G/A cg20891283 chr12:69753455 YEATS4 0.47 5.13 0.3 5.51e-7 Response to diuretic therapy; CESC cis rs9287719 0.967 rs6432113 chr2:10744889 C/T cg00105475 chr2:10696890 NA -0.38 -5.52 -0.32 7.88e-8 Prostate cancer; CESC cis rs2281558 0.517 rs16987966 chr20:25643414 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.51 5.76 0.33 2.34e-8 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs9325144 0.560 rs13377717 chr12:38639474 T/A cg13010199 chr12:38710504 ALG10B -0.44 -6.06 -0.35 4.73e-9 Morning vs. evening chronotype; CESC cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg20476274 chr7:133979776 SLC35B4 0.65 9.4 0.5 2.68e-18 Mean platelet volume; CESC cis rs7264396 0.709 rs2425073 chr20:34293699 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.54 -0.58 3.15e-25 Total cholesterol levels; CESC cis rs7726839 0.540 rs56325086 chr5:640728 G/A cg16447950 chr5:562315 NA -0.57 -6.02 -0.35 5.68e-9 Obesity-related traits; CESC cis rs10463316 0.817 rs1810083 chr5:150776807 A/G cg03212797 chr5:150827313 SLC36A1 0.41 5.13 0.3 5.66e-7 Metabolite levels (Pyroglutamine); CESC cis rs6964587 1.000 rs11982047 chr7:91705274 G/A cg17063962 chr7:91808500 NA 0.54 7.24 0.41 4.99e-12 Breast cancer; CESC cis rs6540559 0.611 rs11810817 chr1:210011747 C/G cg22029157 chr1:209979665 IRF6 0.66 7.39 0.41 1.89e-12 Cleft lip with or without cleft palate; CESC cis rs561341 0.505 rs28708703 chr17:30386845 C/G cg00745463 chr17:30367425 LRRC37B -0.63 -6.16 -0.35 2.69e-9 Hip circumference adjusted for BMI; CESC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg08736216 chr1:53307985 ZYG11A -0.41 -6.89 -0.39 4.15e-11 Monocyte count; CESC cis rs4253772 0.591 rs10854854 chr22:46684706 C/G cg00784671 chr22:46762841 CELSR1 -0.46 -5.16 -0.3 4.96e-7 LDL cholesterol;Cholesterol, total; CESC cis rs858239 0.601 rs4140959 chr7:23170776 C/T cg23682824 chr7:23144976 KLHL7 0.56 7.86 0.43 9.69e-14 Cerebrospinal fluid biomarker levels; CESC cis rs61935443 0.832 rs11107768 chr12:95274182 A/T cg21533806 chr12:95267307 NA -0.58 -7.08 -0.4 1.26e-11 Schizophrenia; CESC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs8077577 0.943 rs62073603 chr17:18064316 C/T cg16794390 chr17:18148240 FLII 0.43 5.87 0.34 1.32e-8 Obesity-related traits; CESC cis rs854765 0.547 rs2955370 chr17:17966945 C/T cg04398451 chr17:18023971 MYO15A 0.73 10.49 0.54 9.47e-22 Total body bone mineral density; CESC cis rs7219021 0.634 rs9905428 chr17:46948709 C/G cg16584676 chr17:46985605 UBE2Z -0.6 -7.25 -0.41 4.46e-12 Schizophrenia or bipolar disorder; CESC cis rs3793683 0.597 rs2182620 chr10:134590715 C/T cg27297192 chr10:134578999 INPP5A 0.39 5.16 0.3 4.75e-7 Migraine; CESC cis rs1050631 0.592 rs9958282 chr18:33710440 T/A cg25426722 chr18:33708991 SLC39A6;ELP2 -0.57 -7.98 -0.44 4.53e-14 Esophageal squamous cell cancer (length of survival); CESC cis rs8114671 0.570 rs3761144 chr20:33544075 C/G cg24642439 chr20:33292090 TP53INP2 0.43 5.04 0.3 8.53e-7 Height; CESC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg00475322 chr7:917719 C7orf20 0.46 5.1 0.3 6.53e-7 Cerebrospinal P-tau181p levels; CESC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg14893161 chr1:205819251 PM20D1 -0.86 -15.16 -0.68 8.52e-38 Menarche (age at onset); CESC cis rs9894429 1.000 rs4074915 chr17:79579230 G/A cg21984481 chr17:79567631 NPLOC4 0.48 7.91 0.44 6.83e-14 Eye color traits; CESC cis rs4409675 0.576 rs2749110 chr1:28235010 T/C cg23691781 chr1:28212827 C1orf38 0.29 5.8 0.34 1.84e-8 Corneal astigmatism; CESC cis rs2486288 0.656 rs11632920 chr15:45551264 C/T cg21132104 chr15:45694354 SPATA5L1 -0.55 -6.75 -0.38 9.23e-11 Glomerular filtration rate; CESC trans rs4662834 0.872 rs6431023 chr2:129476347 A/G cg12497543 chr10:97515377 ENTPD1 -0.36 -6.16 -0.35 2.64e-9 Response to bleomycin (chromatid breaks); CESC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg23758822 chr17:41437982 NA 1.01 15.3 0.68 2.61e-38 Menopause (age at onset); CESC cis rs2070433 0.660 rs11701034 chr21:47793235 A/G cg12379764 chr21:47803548 PCNT 0.69 7.71 0.43 2.5e-13 Lymphocyte counts; CESC cis rs9323205 0.773 rs4334206 chr14:51702414 G/C cg23942311 chr14:51606299 NA -0.45 -5.4 -0.32 1.45e-7 Cancer; CESC cis rs28647808 0.881 rs28602295 chr9:136267471 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC cis rs8058578 1.000 rs7198250 chr16:30746822 C/A cg00531865 chr16:30841666 NA -0.46 -6.26 -0.36 1.51e-9 Multiple myeloma; CESC cis rs9611565 0.546 rs5758431 chr22:42109917 A/G cg17376030 chr22:41985996 PMM1 -0.72 -7.68 -0.43 3.15e-13 Vitiligo; CESC cis rs3733585 0.699 rs7694997 chr4:9947811 A/G cg02734326 chr4:10020555 SLC2A9 -0.41 -5.73 -0.33 2.72e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg10691866 chr7:65817282 TPST1 0.33 5.53 0.32 7.81e-8 Aortic root size; CESC cis rs863345 0.604 rs12118446 chr1:158496235 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.78e-11 Pneumococcal bacteremia; CESC trans rs9929218 0.551 rs2274239 chr16:68725783 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.93 15.86 0.7 2.78e-40 Colorectal cancer; CESC cis rs3820068 0.529 rs79570154 chr1:15990912 T/C cg13390004 chr1:15929781 NA 0.35 5.47 0.32 1.03e-7 Systolic blood pressure; CESC cis rs17253792 0.822 rs17683614 chr14:56041058 G/A cg01858014 chr14:56050164 KTN1 -0.99 -7.46 -0.42 1.21e-12 Putamen volume; CESC trans rs4950322 0.542 rs3766520 chr1:146686228 C/T cg04954894 chr8:38089920 DDHD2 -0.62 -6.34 -0.36 9.73e-10 Protein quantitative trait loci; CESC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg24642844 chr7:1081250 C7orf50 -0.64 -8.13 -0.45 1.67e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2635047 0.638 rs13381713 chr18:44669499 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 5.38 0.31 1.61e-7 Educational attainment; CESC cis rs1387259 0.929 rs2634666 chr12:48663670 G/T cg04545296 chr12:48745243 ZNF641 0.42 7.06 0.4 1.47e-11 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs5758659 1.000 rs5758659 chr22:42622003 C/T cg05082376 chr22:42548792 NA -0.37 -5.5 -0.32 8.95e-8 Cognitive function; CESC trans rs6934970 0.860 rs6902327 chr6:112983118 G/C cg05146922 chr2:10634174 NA -0.37 -6.17 -0.35 2.53e-9 Bipolar disorder (body mass index interaction); CESC cis rs67311347 0.955 rs6599100 chr3:40447362 C/T cg24209194 chr3:40518798 ZNF619 0.46 5.94 0.34 8.93e-9 Renal cell carcinoma; CESC cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg25019033 chr10:957182 NA -0.56 -5.57 -0.32 6.34e-8 Eosinophil percentage of granulocytes; CESC cis rs2108225 0.837 rs7810937 chr7:107447500 A/G cg18560240 chr7:107437656 SLC26A3 -0.44 -5.96 -0.34 7.93e-9 Ulcerative colitis; CESC cis rs796364 0.806 rs74266490 chr2:201005995 A/C cg23649088 chr2:200775458 C2orf69 -0.55 -5.04 -0.3 8.69e-7 Schizophrenia; CESC cis rs7937682 0.889 rs3017767 chr11:111508098 A/G cg09085632 chr11:111637200 PPP2R1B -0.99 -16.01 -0.7 8.36e-41 Primary sclerosing cholangitis; CESC cis rs6541297 1.000 rs2144298 chr1:230280198 T/C cg20703242 chr1:230279135 GALNT2 0.73 11.12 0.56 8.07e-24 Coronary artery disease; CESC cis rs34779708 0.931 rs7099593 chr10:35366878 A/C cg04310649 chr10:35416472 CREM -0.52 -6.4 -0.37 7.03e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01935492 chr4:84256334 HPSE -0.5 -6.44 -0.37 5.46e-10 Fibrinogen levels; CESC cis rs344364 0.511 rs1742473 chr16:1953095 T/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.51 -5.68 -0.33 3.62e-8 Glomerular filtration rate in chronic kidney disease; CESC cis rs4566357 0.615 rs10198406 chr2:227913539 A/G cg11843606 chr2:227700838 RHBDD1 -0.48 -6.58 -0.37 2.45e-10 Coronary artery disease; CESC cis rs5769765 0.954 rs5770709 chr22:50245196 G/T cg26441486 chr22:50317300 CRELD2 -0.4 -5.49 -0.32 9.39e-8 Schizophrenia; CESC cis rs7017914 0.967 rs13256250 chr8:71596193 G/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.09 -0.3 6.93e-7 Bone mineral density; CESC cis rs7714584 1.000 rs7736554 chr5:150258308 T/C cg22134413 chr5:150180641 NA 0.48 5.35 0.31 1.86e-7 Crohn's disease; CESC cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg23711669 chr6:146136114 FBXO30 0.97 14.77 0.67 2.05e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.57 6.96 0.39 2.69e-11 Height; CESC cis rs6500395 0.962 rs2101372 chr16:48627306 G/A cg04672837 chr16:48644449 N4BP1 0.47 5.82 0.34 1.72e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg02725872 chr8:58115012 NA -0.46 -7.18 -0.4 6.99e-12 Developmental language disorder (linguistic errors); CESC trans rs11098499 0.657 rs10434028 chr4:120294464 T/G cg25214090 chr10:38739885 LOC399744 0.66 9.12 0.49 1.88e-17 Corneal astigmatism; CESC cis rs4423214 1.000 rs7928249 chr11:71161063 A/G cg05163923 chr11:71159392 DHCR7 0.85 12.42 0.61 3.08e-28 Vitamin D levels; CESC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg24829409 chr8:58192753 C8orf71 -0.65 -7.68 -0.43 3.03e-13 Developmental language disorder (linguistic errors); CESC cis rs3741151 0.686 rs7944346 chr11:73244230 C/T cg17517138 chr11:73019481 ARHGEF17 0.57 5.17 0.3 4.64e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs559928 0.606 rs1011219 chr11:63973396 A/G cg18225595 chr11:63971243 STIP1 -0.56 -5.59 -0.32 5.68e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs6831352 0.879 rs36034266 chr4:100061388 T/C cg12011299 chr4:100065546 ADH4 -0.59 -6.59 -0.38 2.35e-10 Alcohol dependence; CESC cis rs5769765 0.913 rs8135071 chr22:50299587 T/C cg02269571 chr22:50332266 NA -0.49 -6.49 -0.37 4.14e-10 Schizophrenia; CESC cis rs11677370 0.603 rs10174064 chr2:3849806 C/T cg17052675 chr2:3827356 NA -0.44 -5.67 -0.33 3.78e-8 Type 2 diabetes; CESC cis rs7772486 0.875 rs1331639 chr6:146431869 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -11.06 -0.56 1.21e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg15605315 chr1:45957053 TESK2 0.48 6.23 0.36 1.8e-9 High light scatter reticulocyte count; CESC cis rs2806561 0.765 rs1757046 chr1:23511821 T/C cg12483005 chr1:23474871 LUZP1 0.38 6.03 0.35 5.51e-9 Height; CESC cis rs17376456 1.000 rs61132622 chr5:93539684 G/A cg25358565 chr5:93447407 FAM172A 1.16 11.45 0.58 6.45e-25 Diabetic retinopathy; CESC cis rs709400 0.930 rs10149249 chr14:104047757 C/T cg12935359 chr14:103987150 CKB -0.47 -6.2 -0.36 2.1e-9 Body mass index; CESC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.64 0.47 5.45e-16 Bipolar disorder; CESC cis rs9611565 0.525 rs9611549 chr22:41705909 C/G cg03806693 chr22:41940476 POLR3H -0.76 -8.65 -0.47 5.19e-16 Vitiligo; CESC cis rs9443645 0.527 rs12527806 chr6:79507667 A/T cg05283184 chr6:79620031 NA -0.36 -5.29 -0.31 2.62e-7 Intelligence (multi-trait analysis); CESC cis rs73110464 0.609 rs727266 chr12:53356411 C/T cg16329197 chr12:53359506 NA -0.68 -9.95 -0.52 4.95e-20 Cancer (pleiotropy); CESC cis rs11792861 0.926 rs1051474 chr9:111881856 T/C cg13535736 chr9:111863775 C9orf5 -0.51 -6.71 -0.38 1.16e-10 Menarche (age at onset); CESC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs367615 0.879 rs2201015 chr5:108947450 C/T cg17395555 chr5:108820864 NA 0.49 6.94 0.39 2.98e-11 Colorectal cancer (SNP x SNP interaction); CESC cis rs910316 1.000 rs10140851 chr14:75512612 G/A cg08847533 chr14:75593920 NEK9 0.99 17.94 0.74 1.18e-47 Height; CESC cis rs7937682 0.961 rs4935790 chr11:111633014 T/C cg09085632 chr11:111637200 PPP2R1B 1.11 15.23 0.68 4.83e-38 Primary sclerosing cholangitis; CESC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg21144161 chr5:423903 AHRR 0.37 5.98 0.34 7.12e-9 Cystic fibrosis severity; CESC cis rs7666738 0.546 rs13149516 chr4:98913030 T/A cg17366294 chr4:99064904 C4orf37 0.52 6.57 0.37 2.65e-10 Colonoscopy-negative controls vs population controls; CESC cis rs78456975 0.941 rs11886649 chr2:1567757 A/G cg26248373 chr2:1572462 NA -0.55 -5.27 -0.31 2.84e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Parkinson's disease; CESC cis rs4076764 0.958 rs6688997 chr1:163411562 G/A cg24596788 chr1:163392923 NA -0.51 -7.3 -0.41 3.38e-12 Motion sickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10277268 chr16:30825733 NA 0.6 6.97 0.39 2.54e-11 Gut microbiome composition (summer); CESC trans rs7980799 0.649 rs10772088 chr12:33663849 A/T cg26384229 chr12:38710491 ALG10B -0.58 -8.17 -0.45 1.26e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs5753618 0.583 rs7285619 chr22:31842554 C/T cg00478049 chr22:31556069 RNF185 -0.43 -5.08 -0.3 7e-7 Colorectal cancer; CESC cis rs3091242 0.933 rs7541095 chr1:25761291 T/C cg03538708 chr1:25844672 NA -0.4 -6.08 -0.35 4.21e-9 Erythrocyte sedimentation rate; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21547979 chr19:49141364 SEC1;DBP;CA11 0.49 6.19 0.36 2.3e-9 Ulcerative colitis; CESC trans rs1814175 0.817 rs10769618 chr11:49822336 A/G cg03929089 chr4:120376271 NA -0.91 -15.19 -0.68 6.5e-38 Height; CESC cis rs111706465 1 rs111706465 chr2:239452382 A/C cg18131467 chr2:239335373 ASB1 -0.66 -5.25 -0.31 3.12e-7 Morning vs. evening chronotype; CESC cis rs68170813 0.605 rs10464620 chr7:107135653 A/G cg02696742 chr7:106810147 HBP1 0.55 5.08 0.3 7.25e-7 Coronary artery disease; CESC cis rs921968 0.643 rs471846 chr2:219432237 C/T cg02176678 chr2:219576539 TTLL4 0.39 6.8 0.39 6.94e-11 Mean corpuscular hemoglobin concentration; CESC cis rs2243480 1.000 rs34970380 chr7:65431493 C/T cg13147721 chr7:65941812 NA -0.9 -8.7 -0.47 3.69e-16 Diabetic kidney disease; CESC cis rs854765 0.655 rs4470201 chr17:17844870 G/A cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.89e-9 Total body bone mineral density; CESC cis rs9611519 0.639 rs7290458 chr22:41476337 C/T cg03806693 chr22:41940476 POLR3H 0.42 5.11 0.3 6.24e-7 Neuroticism; CESC cis rs753778 0.629 rs2278447 chr8:142206905 G/C cg23750338 chr8:142222470 SLC45A4 0.36 5.2 0.3 4.03e-7 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs9902453 0.817 rs59420007 chr17:28196114 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 8.01 0.44 3.58e-14 Coffee consumption (cups per day); CESC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.18 0.53 9.01e-21 Mean platelet volume; CESC trans rs6934970 0.860 rs4509158 chr6:112981509 T/C cg05146922 chr2:10634174 NA -0.38 -6.18 -0.35 2.35e-9 Bipolar disorder (body mass index interaction); CESC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg05332525 chr7:65337924 VKORC1L1 -0.5 -6.16 -0.35 2.63e-9 Aortic root size; CESC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg25036284 chr2:26402008 FAM59B -0.59 -6.88 -0.39 4.37e-11 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg00129232 chr17:37814104 STARD3 -0.53 -6.9 -0.39 3.76e-11 Glomerular filtration rate (creatinine); CESC cis rs2635047 0.638 rs9961383 chr18:44604001 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.11 0.35 3.59e-9 Educational attainment; CESC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg06456125 chr7:65229604 NA 0.43 5.61 0.33 5.03e-8 Aortic root size; CESC cis rs1348850 0.793 rs12990917 chr2:178487259 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.36 0.41 2.29e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs714031 0.967 rs4821910 chr22:40067470 T/C cg21377881 chr22:40064566 CACNA1I -0.33 -5.25 -0.31 3.05e-7 Schizophrenia; CESC cis rs74377301 1 rs74377301 chr7:123232495 C/T cg03229431 chr7:123269106 ASB15 -0.39 -5.19 -0.3 4.09e-7 Left ventricular obstructive tract defect (inherited effect); CESC cis rs815815 0.608 rs815808 chr2:47381097 C/T cg27223769 chr2:47403360 CALM2 0.55 6.44 0.37 5.48e-10 Dialysis-related mortality; CESC cis rs644148 0.781 rs630469 chr19:44970167 T/C cg15540054 chr19:45004280 ZNF180 -0.72 -8.77 -0.47 2.23e-16 Personality dimensions; CESC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.65 0.64 1.8e-32 Prudent dietary pattern; CESC cis rs4911259 0.552 rs11700082 chr20:31460244 A/G cg13636640 chr20:31349939 DNMT3B -0.56 -7.81 -0.43 1.34e-13 Inflammatory bowel disease; CESC cis rs8072100 0.840 rs11079774 chr17:45479706 C/G cg25173405 chr17:45401733 C17orf57 -0.41 -5.47 -0.32 1.02e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg21496518 chr3:15374154 SH3BP5 -0.36 -6.12 -0.35 3.26e-9 Breast cancer; CESC cis rs1975974 1.000 rs1985717 chr17:21731807 T/A cg18423549 chr17:21743878 NA -0.52 -7.08 -0.4 1.3e-11 Psoriasis; CESC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.85e-10 Total body bone mineral density; CESC cis rs11098499 1.000 rs6849889 chr4:120186348 A/C cg09307838 chr4:120376055 NA 0.89 11.8 0.59 4.03e-26 Corneal astigmatism; CESC cis rs6543140 0.964 rs13383602 chr2:103085962 C/T cg04239558 chr2:103089729 SLC9A4 0.47 6.23 0.36 1.83e-9 Blood protein levels; CESC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02322203 chr16:67464610 HSD11B2 0.61 6.72 0.38 1.14e-10 Gut microbiome composition (summer); CESC cis rs10883723 0.810 rs1056857 chr10:104240003 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.44 0.42 1.43e-12 Allergic disease (asthma, hay fever or eczema); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg24167567 chr20:21283808 XRN2 -0.43 -6.48 -0.37 4.52e-10 Breast cancer; CESC cis rs4423214 0.959 rs12794668 chr11:71168715 C/T cg05163923 chr11:71159392 DHCR7 0.77 10.41 0.54 1.69e-21 Vitamin D levels; CESC trans rs9325144 0.555 rs4882284 chr12:38710459 C/T cg23762105 chr12:34175262 ALG10 0.49 6.62 0.38 2.02e-10 Morning vs. evening chronotype; CESC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg05368731 chr17:41323189 NBR1 0.78 10.34 0.54 2.84e-21 Menopause (age at onset); CESC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg22920501 chr2:26401640 FAM59B -0.66 -8.06 -0.44 2.66e-14 Gut microbiome composition (summer); CESC cis rs6893300 0.785 rs7705530 chr5:179190994 C/T cg14593053 chr5:179126677 CANX -0.49 -5.85 -0.34 1.43e-8 Resting heart rate; CESC cis rs704 0.523 rs11080054 chr17:26645991 G/A cg10494684 chr17:26645200 TMEM97 -0.39 -5.39 -0.31 1.56e-7 Osteoprotegerin levels; CESC cis rs9314323 0.767 rs6557915 chr8:26209062 C/A cg11498726 chr8:26250323 BNIP3L -0.46 -6.72 -0.38 1.08e-10 Red cell distribution width; CESC cis rs7937682 0.921 rs34584980 chr11:111441537 G/A cg22437258 chr11:111473054 SIK2 -0.61 -6.1 -0.35 3.77e-9 Primary sclerosing cholangitis; CESC cis rs228769 0.635 rs228754 chr17:42116056 C/A cg19774624 chr17:42201019 HDAC5 0.53 6.04 0.35 5.08e-9 Bone mineral density (hip);Bone mineral density (spine); CESC cis rs7208859 0.623 rs9890855 chr17:29111707 G/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2242116 0.796 rs9852082 chr3:46972377 T/C cg02527881 chr3:46936655 PTH1R -0.5 -6.91 -0.39 3.53e-11 Birth weight; CESC cis rs962856 0.619 rs1842958 chr2:67576559 G/T cg09028215 chr2:67624308 ETAA1 -0.43 -5.14 -0.3 5.38e-7 Pancreatic cancer; CESC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg04756594 chr16:24857601 SLC5A11 0.45 5.53 0.32 7.79e-8 Intelligence (multi-trait analysis); CESC cis rs9814567 0.752 rs4318591 chr3:134328333 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.41 -5.16 -0.3 4.8e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7666738 0.830 rs880470 chr4:98922522 A/T cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.546 rs34077262 chr22:42061639 A/G cg03806693 chr22:41940476 POLR3H 0.97 11.68 0.58 1.1e-25 Vitiligo; CESC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg20243544 chr17:37824526 PNMT -0.5 -5.96 -0.34 8.2e-9 Glomerular filtration rate (creatinine); CESC cis rs2573652 1.000 rs2727196 chr15:100513529 C/T cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.45 -0.32 1.13e-7 Height; CESC cis rs7809950 1.000 rs2712189 chr7:107195747 G/A cg23024343 chr7:107201750 COG5 -0.42 -5.87 -0.34 1.33e-8 Coronary artery disease; CESC cis rs9300255 0.506 rs11057251 chr12:123791227 A/G cg00376283 chr12:123451042 ABCB9 -0.59 -8.05 -0.44 2.72e-14 Neutrophil percentage of white cells; CESC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4727027 0.801 rs12666337 chr7:148796253 C/T cg23583168 chr7:148888333 NA -0.79 -12.08 -0.6 4.71e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg22823121 chr1:150693482 HORMAD1 0.44 6.19 0.36 2.26e-9 Melanoma; CESC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg11168104 chr5:1857477 NA -0.38 -5.67 -0.33 3.63e-8 Cardiovascular disease risk factors; CESC cis rs13102973 0.863 rs13129178 chr4:135858219 A/C cg14419869 chr4:135874104 NA 0.34 5.28 0.31 2.75e-7 Subjective well-being; CESC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg27266027 chr21:40555129 PSMG1 0.48 5.69 0.33 3.29e-8 Cognitive function; CESC cis rs6687430 0.526 rs12117392 chr1:10608583 T/C cg07384165 chr1:10488281 NA -0.48 -6.58 -0.37 2.5e-10 Hand grip strength; CESC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs11098499 0.954 rs28572238 chr4:120316686 T/G cg25214090 chr10:38739885 LOC399744 0.69 9.38 0.5 3.13e-18 Corneal astigmatism; CESC cis rs9815354 0.812 rs116393551 chr3:41865476 G/A cg03022575 chr3:42003672 ULK4 0.66 5.38 0.31 1.66e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg17005319 chr11:655579 DEAF1 0.51 5.11 0.3 6.27e-7 Systemic lupus erythematosus; CESC cis rs1729951 0.575 rs16844326 chr3:136678385 G/C cg25687071 chr3:136751404 NA 0.39 5.17 0.3 4.65e-7 Neuroticism; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg01204655 chr5:156692969 CYFIP2 -0.44 -6.02 -0.35 5.65e-9 Attention deficit hyperactivity disorder; CESC cis rs17376456 0.825 rs34592268 chr5:93232751 G/C cg21475434 chr5:93447410 FAM172A 0.75 6.64 0.38 1.73e-10 Diabetic retinopathy; CESC cis rs10949834 0.878 rs36010170 chr7:73499498 C/A cg07137043 chr7:73588983 EIF4H -0.64 -5.51 -0.32 8.31e-8 Verbal memory performance (residualized delayed recall change); CESC cis rs10754283 0.535 rs1215507 chr1:90088895 A/G cg21401794 chr1:90099060 LRRC8C 0.4 5.1 0.3 6.56e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2073300 1.000 rs6132623 chr20:23442324 T/A cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9649213 0.559 rs56997921 chr7:98009224 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.43 -5.81 -0.34 1.82e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1580019 0.587 rs9638880 chr7:32552401 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.9 0.76 5.11e-51 Cognitive ability; CESC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg11764359 chr7:65958608 NA 0.52 6.83 0.39 5.78e-11 Aortic root size; CESC cis rs67478160 0.643 rs6575997 chr14:104228546 C/T cg01849466 chr14:104193079 ZFYVE21 0.5 7.2 0.4 6.23e-12 Schizophrenia; CESC cis rs425277 0.565 rs3128293 chr1:2065339 A/G cg04315214 chr1:2043799 PRKCZ 0.51 8.2 0.45 1.03e-14 Height; CESC cis rs12464559 0.522 rs7583148 chr2:152620986 C/T cg01189475 chr2:152685088 ARL5A 0.7 6.72 0.38 1.13e-10 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs478304 0.651 rs4014192 chr11:65498915 C/T cg10518572 chr11:65560635 OVOL1 -0.33 -6.61 -0.38 2.09e-10 Acne (severe); CESC cis rs763121 0.853 rs1569492 chr22:38975511 A/G cg06544989 chr22:39130855 UNC84B -0.44 -8.23 -0.45 8.58e-15 Menopause (age at onset); CESC cis rs7927771 1.000 rs7105282 chr11:47805614 C/A cg20307385 chr11:47447363 PSMC3 -0.5 -6.15 -0.35 2.89e-9 Subjective well-being; CESC trans rs1814175 0.653 rs10839480 chr11:50034556 C/T cg15704280 chr7:45808275 SEPT13 -1.05 -20.97 -0.79 3.22e-58 Height; CESC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7937682 0.883 rs472465 chr11:111468962 C/T cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC cis rs67311347 0.544 rs4974047 chr3:40339653 G/T cg09455208 chr3:40491958 NA 0.36 6.35 0.36 9.37e-10 Renal cell carcinoma; CESC cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg23711669 chr6:146136114 FBXO30 0.95 14.46 0.66 2.54e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs2354432 0.607 rs6703847 chr1:146669444 G/A cg25205988 chr1:146714368 CHD1L 1.19 9.08 0.49 2.58e-17 Mitochondrial DNA levels; CESC cis rs6547741 0.743 rs7564625 chr2:27862397 C/T cg27432699 chr2:27873401 GPN1 -0.61 -9.12 -0.49 1.9e-17 Oral cavity cancer; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg27552081 chr17:25621774 WSB1 0.46 6.22 0.36 1.96e-9 Tetralogy of Fallot; CESC cis rs72634258 0.554 rs10462018 chr1:7879627 C/T cg26816564 chr1:7831052 VAMP3 0.64 6.1 0.35 3.72e-9 Inflammatory bowel disease; CESC cis rs12681288 0.862 rs7814070 chr8:1020991 A/G cg04851639 chr8:1020857 NA -0.38 -8.67 -0.47 4.47e-16 Schizophrenia; CESC cis rs3815700 0.688 rs259252 chr19:33149991 G/C cg25945090 chr19:33463020 C19orf40;CCDC123 0.75 5.2 0.3 3.95e-7 Eosinophilic esophagitis; CESC cis rs1348850 0.914 rs7565022 chr2:178320222 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.74 10.48 0.54 1.04e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10242455 0.702 rs6974831 chr7:99131605 A/G cg25640893 chr7:99214727 ZNF498 0.71 5.19 0.3 4.21e-7 Blood metabolite levels; CESC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg25072359 chr17:41440525 NA 0.46 6.13 0.35 3.09e-9 Menopause (age at onset); CESC cis rs11792861 0.962 rs72607162 chr9:111793719 T/C cg05043794 chr9:111880884 C9orf5 -0.42 -6.93 -0.39 3.25e-11 Menarche (age at onset); CESC cis rs78456975 1.000 rs13416881 chr2:1554808 G/A cg01028140 chr2:1542097 TPO -0.58 -5.9 -0.34 1.1e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs2425143 0.908 rs12480111 chr20:34423186 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.64 5.27 0.31 2.82e-7 Blood protein levels; CESC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg24562669 chr7:97807699 LMTK2 0.51 7.57 0.42 6.13e-13 Prostate cancer (SNP x SNP interaction); CESC trans rs61931739 0.817 rs7963318 chr12:34244929 C/G cg26384229 chr12:38710491 ALG10B -0.48 -6.76 -0.38 8.92e-11 Morning vs. evening chronotype; CESC cis rs3820928 0.904 rs1835159 chr2:227764057 A/G cg11843606 chr2:227700838 RHBDD1 -0.44 -5.85 -0.34 1.46e-8 Pulmonary function; CESC cis rs9291683 0.530 rs10939620 chr4:9946132 C/T cg00071950 chr4:10020882 SLC2A9 -0.77 -13.95 -0.65 1.55e-33 Bone mineral density; CESC cis rs9303542 0.625 rs6504340 chr17:46617019 A/G cg04904318 chr17:46607828 HOXB1 0.48 5.44 0.32 1.22e-7 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg25427524 chr10:38739819 LOC399744 -0.65 -9.48 -0.5 1.51e-18 Extrinsic epigenetic age acceleration; CESC cis rs660899 0.595 rs37459 chr1:44289397 A/G cg11704212 chr1:44303111 ST3GAL3 -0.4 -5.36 -0.31 1.78e-7 Hypertension risk in short sleep duration; CESC cis rs1707322 0.752 rs8179402 chr1:46142466 C/A cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7084402 1.000 rs4113952 chr10:60268599 A/G cg07615347 chr10:60278583 BICC1 0.58 8.71 0.47 3.33e-16 Refractive error; CESC cis rs6499255 0.951 rs11641233 chr16:69734563 C/T cg15192750 chr16:69999425 NA 0.48 5.69 0.33 3.36e-8 IgE levels; CESC cis rs7914558 1.000 rs6584540 chr10:104927634 A/G cg04362960 chr10:104952993 NT5C2 0.47 6.21 0.36 2e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs561341 0.714 rs75861674 chr17:30304317 A/G cg19193384 chr17:30244184 NA -0.58 -6.14 -0.35 2.98e-9 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs7672720 chr4:98938760 A/T cg03467027 chr4:99064603 C4orf37 0.48 5.96 0.34 7.94e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9828933 0.678 rs704366 chr3:63871648 A/G cg16258503 chr3:63850278 ATXN7;THOC7 0.65 6.48 0.37 4.53e-10 Type 2 diabetes; CESC cis rs2658782 1.000 rs2605582 chr11:93163799 C/T cg15737290 chr11:93063684 CCDC67 0.53 6.62 0.38 2e-10 Pulmonary function decline; CESC cis rs73019876 0.869 rs10418985 chr19:22147952 T/C cg11619707 chr19:22235551 ZNF257 -0.28 -5.21 -0.3 3.76e-7 Testicular germ cell tumor; CESC cis rs9913156 0.793 rs72835643 chr17:4573612 G/A cg19197139 chr17:4613644 ARRB2 0.95 10.62 0.55 3.4e-22 Lymphocyte counts; CESC cis rs4466137 0.830 rs6886442 chr5:82973210 A/C cg16102102 chr5:83017553 HAPLN1 0.34 5.25 0.31 3.15e-7 Prostate cancer; CESC trans rs7326068 0.576 rs9552273 chr13:21333750 A/C cg00192819 chr18:76486611 NA 0.43 6.18 0.35 2.37e-9 Schizophrenia, bipolar disorder and depression (combined); CESC cis rs651907 0.557 rs35850993 chr3:101437433 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 6.77 0.38 8.14e-11 Colorectal cancer; CESC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg00166722 chr3:10149974 C3orf24 0.53 6.16 0.35 2.74e-9 Alzheimer's disease; CESC cis rs10752881 1.000 rs10797811 chr1:182984432 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.34 0.63 2.03e-31 Colorectal cancer; CESC cis rs7500321 1.000 rs7500321 chr16:28977020 G/A cg08761264 chr16:28874980 SH2B1 0.47 5.62 0.33 4.85e-8 Intelligence (multi-trait analysis); CESC cis rs4523957 0.651 rs898748 chr17:2085475 G/T cg16513277 chr17:2031491 SMG6 -0.71 -10.17 -0.53 1.04e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1775715 0.677 rs2808074 chr10:32179184 A/C cg18675610 chr10:32216311 ARHGAP12 0.35 5.33 0.31 2.08e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs72627123 0.656 rs17096314 chr14:74567952 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.74 5.09 0.3 6.91e-7 Morning vs. evening chronotype; CESC cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg01579765 chr21:45077557 HSF2BP -0.53 -8.77 -0.47 2.19e-16 Mean corpuscular volume; CESC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg18876405 chr7:65276391 NA -0.57 -7.55 -0.42 6.85e-13 Aortic root size; CESC cis rs8067545 0.611 rs2703807 chr17:20109189 C/T cg13482628 chr17:19912719 NA -0.44 -5.92 -0.34 9.91e-9 Schizophrenia; CESC cis rs10504229 0.906 rs2270607 chr8:58194699 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -8.03 -0.44 3.19e-14 Developmental language disorder (linguistic errors); CESC cis rs10838687 0.736 rs326224 chr11:47255598 T/C cg25783544 chr11:47291846 MADD -0.55 -6.14 -0.35 2.94e-9 Proinsulin levels; CESC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 8.6 0.47 7.14e-16 Personality dimensions; CESC cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg05340658 chr4:99064831 C4orf37 0.84 12.81 0.62 1.45e-29 Colonoscopy-negative controls vs population controls; CESC cis rs12971120 0.891 rs2278158 chr18:72178300 G/T cg25817165 chr18:72167213 CNDP2 -0.61 -7.36 -0.41 2.37e-12 Refractive error; CESC cis rs7945705 0.967 rs10769973 chr11:8928615 C/G cg21881798 chr11:8931708 C11orf17;ST5 0.53 8.36 0.46 3.52e-15 Hemoglobin concentration; CESC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg17376030 chr22:41985996 PMM1 -0.55 -6.16 -0.35 2.68e-9 Vitiligo; CESC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg04369109 chr6:150039330 LATS1 -0.43 -5.84 -0.34 1.51e-8 Lung cancer; CESC cis rs34779708 0.931 rs7897457 chr10:35386040 A/G cg04310649 chr10:35416472 CREM -0.52 -6.4 -0.37 7.03e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs2904967 0.636 rs239256 chr11:64987391 C/T cg23743554 chr11:65321226 LTBP3 -0.4 -5.21 -0.3 3.82e-7 Mean corpuscular volume; CESC cis rs734999 0.588 rs11585048 chr1:2534087 C/T cg20673091 chr1:2541236 MMEL1 0.43 7.23 0.41 5.16e-12 Ulcerative colitis; CESC cis rs9910055 0.530 rs2269905 chr17:42294462 A/G cg19774624 chr17:42201019 HDAC5 -0.6 -8.5 -0.46 1.39e-15 Total body bone mineral density; CESC cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg03433033 chr1:76189801 ACADM 0.76 10.66 0.55 2.64e-22 Blood metabolite levels;Acylcarnitine levels; CESC cis rs921968 0.541 rs514356 chr2:219375018 C/T cg02176678 chr2:219576539 TTLL4 0.5 9.05 0.49 3.15e-17 Mean corpuscular hemoglobin concentration; CESC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg09699651 chr6:150184138 LRP11 0.4 5.26 0.31 2.96e-7 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03753597 chr21:47706070 MCM3AP;C21orf57 0.65 7.95 0.44 5.4e-14 Gut microbiome composition (summer); CESC cis rs34779708 0.931 rs12261654 chr10:35322024 G/A cg03585969 chr10:35415529 CREM 0.76 10.17 0.53 9.87e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs4835473 0.800 rs1988210 chr4:144912663 G/C cg25736465 chr4:144833511 NA 0.43 6.54 0.37 3.17e-10 Immature fraction of reticulocytes; CESC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg12379764 chr21:47803548 PCNT -0.52 -6.26 -0.36 1.52e-9 Testicular germ cell tumor; CESC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg17376030 chr22:41985996 PMM1 0.6 6.6 0.38 2.27e-10 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26788107 chr19:34895122 PDCD2L -0.55 -6.31 -0.36 1.17e-9 Gut microbiome composition (summer); CESC trans rs4596713 0.508 rs4745650 chr9:71777892 G/A cg16512924 chr15:28394682 HERC2 0.48 6.14 0.35 2.95e-9 Headache; CESC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.71 0.38 1.17e-10 Bipolar disorder; CESC cis rs9399135 0.967 rs6909975 chr6:135315570 C/T cg24558204 chr6:135376177 HBS1L 0.5 6.77 0.38 8.49e-11 Red blood cell count; CESC cis rs12497850 1.000 rs4858798 chr3:48727112 C/T cg06641503 chr3:48959341 ARIH2 -0.32 -5.03 -0.3 9.07e-7 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18891615 chr8:101962925 YWHAZ 0.57 6.17 0.35 2.5e-9 Gut microbiome composition (summer); CESC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.88 7.86 0.43 9.49e-14 Depression; CESC cis rs2280018 0.538 rs7404526 chr16:15129162 A/G cg27102117 chr16:15229624 NA 0.52 8.08 0.44 2.34e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs9291683 0.588 rs2240722 chr4:10020757 A/G cg02734326 chr4:10020555 SLC2A9 0.52 7.36 0.41 2.28e-12 Bone mineral density; CESC cis rs8078723 0.738 rs8066582 chr17:38146929 A/G cg17467752 chr17:38218738 THRA -0.58 -8.86 -0.48 1.22e-16 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs763121 0.962 rs6001159 chr22:38966487 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.45 0.61 2.62e-28 Menopause (age at onset); CESC cis rs1808579 1.000 rs1808579 chr18:21104888 C/T cg14672496 chr18:21087552 C18orf8 0.44 6.57 0.37 2.6e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs7618501 0.699 rs6446187 chr3:49907111 C/A cg24110177 chr3:50126178 RBM5 -0.45 -6.04 -0.35 5.07e-9 Intelligence (multi-trait analysis); CESC cis rs7772486 0.817 rs12198065 chr6:146385286 G/C cg05347473 chr6:146136440 FBXO30 0.5 6.55 0.37 2.9e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9467711 0.606 rs1977 chr6:26377546 A/G cg14345882 chr6:26364793 BTN3A2 0.58 6.57 0.37 2.59e-10 Autism spectrum disorder or schizophrenia; CESC cis rs2204008 0.603 rs4397954 chr12:38089157 T/C cg26384229 chr12:38710491 ALG10B 0.72 10.07 0.53 2.16e-20 Bladder cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13309628 chr20:3801056 C20orf29 -0.46 -6.58 -0.37 2.48e-10 Gambling; CESC trans rs10411161 0.702 rs11878586 chr19:52388576 A/G cg22319618 chr22:45562946 NUP50 -0.75 -7.58 -0.42 5.85e-13 Breast cancer; CESC cis rs1707322 0.717 rs1972410 chr1:46080947 G/T cg03146154 chr1:46216737 IPP 0.79 10.9 0.56 4.22e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9303401 1.000 rs9904677 chr17:56873025 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.73 9.6 0.51 6.34e-19 Cognitive test performance; CESC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg18404041 chr3:52824283 ITIH1 -0.4 -6.73 -0.38 1.04e-10 Electroencephalogram traits; CESC cis rs7923609 0.967 rs10740126 chr10:65210935 A/G cg01631684 chr10:65280961 REEP3 -0.43 -5.39 -0.31 1.55e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs2997447 0.846 rs61775430 chr1:26411109 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.14e-7 QRS complex (12-leadsum); CESC cis rs9486719 0.947 rs2472893 chr6:96870048 G/C cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg08736216 chr1:53307985 ZYG11A -0.42 -7.09 -0.4 1.19e-11 Monocyte count; CESC cis rs2066819 1.000 rs118130855 chr12:56677979 T/A cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs959260 1.000 rs4789183 chr17:73380221 G/A cg20590849 chr17:73267439 MIF4GD -0.57 -6.73 -0.38 1.07e-10 Systemic lupus erythematosus; CESC cis rs4900538 0.855 rs12587464 chr14:102886561 G/C cg18135206 chr14:102964638 TECPR2 -0.72 -8.98 -0.48 5.19e-17 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg25036284 chr2:26402008 FAM59B 0.82 8.69 0.47 3.88e-16 Gut microbiome composition (summer); CESC cis rs4957048 0.891 rs11960196 chr5:568857 C/A cg16447950 chr5:562315 NA -0.66 -7.73 -0.43 2.18e-13 Ulcerative colitis; CESC cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.6 -8.64 -0.47 5.52e-16 Personality dimensions; CESC cis rs2573652 1.000 rs2573652 chr15:100514614 A/G cg09918751 chr15:100517450 ADAMTS17 -0.39 -7.56 -0.42 6.72e-13 Height; CESC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg05863683 chr7:1912471 MAD1L1 0.45 6.85 0.39 5.1e-11 Bipolar disorder and schizophrenia; CESC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.09 0.6 4.37e-27 Alzheimer's disease; CESC cis rs7923609 0.870 rs10822156 chr10:65080727 T/C cg01631684 chr10:65280961 REEP3 -0.45 -5.61 -0.33 5.09e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs10088262 0.629 rs7015861 chr8:124795613 C/T cg20713898 chr8:124780851 FAM91A1 -0.67 -9.08 -0.49 2.61e-17 Pancreatic cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12145550 chr20:44600942 ZNF335 -0.47 -6.58 -0.37 2.51e-10 Ulcerative colitis; CESC cis rs1800469 1.000 rs1982072 chr19:41864509 T/A cg09537434 chr19:41945824 ATP5SL -0.71 -8.63 -0.47 5.86e-16 Colorectal cancer; CESC cis rs7116495 0.609 rs7942626 chr11:71703849 G/A cg18441811 chr11:71824068 C11orf51 -0.78 -5.3 -0.31 2.43e-7 Severe influenza A (H1N1) infection; CESC cis rs6502050 0.769 rs4789741 chr17:80119184 A/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs1387259 0.690 rs1601985 chr12:48761914 A/G cg04545296 chr12:48745243 ZNF641 0.37 6.26 0.36 1.52e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs7789940 0.904 rs56919252 chr7:75937520 T/C cg10167463 chr7:75959203 YWHAG -0.53 -6.31 -0.36 1.16e-9 Multiple sclerosis; CESC cis rs637571 0.584 rs7107912 chr11:65603252 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.68 -8.68 -0.47 4.24e-16 Eosinophil percentage of white cells; CESC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg09365446 chr1:150670422 GOLPH3L 0.38 5.32 0.31 2.22e-7 Tonsillectomy; CESC cis rs1355223 0.506 rs7131272 chr11:34869548 A/G cg11058730 chr11:34937778 PDHX;APIP 0.53 6.43 0.37 6.05e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs10089 0.953 rs7713860 chr5:127428789 G/T cg19767477 chr5:127420684 SLC12A2 -0.43 -5.88 -0.34 1.23e-8 Ileal carcinoids; CESC cis rs2228479 0.618 rs34689166 chr16:89860697 C/T cg00800038 chr16:89945340 TCF25 -0.9 -7.49 -0.42 1.01e-12 Skin colour saturation; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21852503 chr1:40348977 TRIT1 -0.5 -6.0 -0.35 6.61e-9 Ulcerative colitis; CESC cis rs1691799 0.867 rs1027399 chr12:66760942 G/A cg16791601 chr12:66731901 HELB -0.77 -13.44 -0.64 9.26e-32 White blood cell count (basophil); CESC cis rs6570726 0.935 rs376991 chr6:145828073 G/C cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg22535103 chr8:58192502 C8orf71 -1.01 -12.36 -0.6 5.35e-28 Developmental language disorder (linguistic errors); CESC cis rs9905704 0.647 rs12940492 chr17:56954655 C/G cg12560992 chr17:57184187 TRIM37 0.62 7.85 0.43 1.03e-13 Testicular germ cell tumor; CESC cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 -0.68 -9.08 -0.49 2.58e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4268898 0.931 rs7603997 chr2:24524958 C/T cg20701182 chr2:24300061 SF3B14 0.48 5.78 0.33 2.14e-8 Asthma; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23921860 chr17:4608406 PELP1 -0.45 -6.2 -0.36 2.15e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1707322 1.000 rs12077546 chr1:46431806 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1707322 0.717 rs3014249 chr1:46079493 A/G cg03146154 chr1:46216737 IPP -0.8 -11.11 -0.56 8.69e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7481584 0.626 rs2071103 chr11:3040087 C/T cg25174290 chr11:3078921 CARS -0.44 -6.04 -0.35 5.21e-9 Calcium levels; CESC cis rs362272 0.525 rs910568 chr4:3307373 A/G cg08886695 chr4:3369023 RGS12 -0.42 -5.6 -0.33 5.32e-8 Serum sulfate level; CESC cis rs11779988 0.538 rs12541567 chr8:17920077 T/A cg18067069 chr8:17937731 ASAH1 -0.47 -6.35 -0.36 9.38e-10 Breast cancer; CESC cis rs7267979 0.668 rs4815398 chr20:25237338 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.6 -8.89 -0.48 9.62e-17 Liver enzyme levels (alkaline phosphatase); CESC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg11663144 chr21:46675770 NA 0.5 7.56 0.42 6.5e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.62 0.33 4.83e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7219021 0.926 rs56144347 chr17:46856640 C/T cg16584676 chr17:46985605 UBE2Z -0.56 -6.32 -0.36 1.08e-9 Schizophrenia or bipolar disorder; CESC cis rs2415984 0.622 rs1761027 chr14:46929611 G/A cg14871534 chr14:47121158 RPL10L 0.35 5.38 0.31 1.67e-7 Number of children ever born; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11342277 chr1:116915598 ATP1A1 -0.45 -6.16 -0.35 2.74e-9 Fibrinogen levels; CESC cis rs2204008 0.774 rs7304438 chr12:38361146 T/G cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.62e-9 Bladder cancer; CESC cis rs7927771 0.524 rs7124396 chr11:47787434 T/G cg20307385 chr11:47447363 PSMC3 -0.58 -8.01 -0.44 3.54e-14 Subjective well-being; CESC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg16262614 chr3:133464971 TF 0.28 5.07 0.3 7.52e-7 Iron status biomarkers; CESC cis rs933688 1.000 rs6452951 chr5:90653868 T/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.17 16.78 0.72 1.55e-43 Smoking behavior; CESC cis rs7267979 1.000 rs2482919 chr20:25299756 T/C cg08601574 chr20:25228251 PYGB -0.36 -5.13 -0.3 5.74e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09378111 chr2:211036309 C2orf67 -0.45 -6.42 -0.37 6.36e-10 Gambling; CESC cis rs854765 0.583 rs12452219 chr17:17829423 C/T cg09796270 chr17:17721594 SREBF1 0.46 6.39 0.37 7.34e-10 Total body bone mineral density; CESC cis rs1023500 0.573 rs133374 chr22:42465941 G/A cg04733989 chr22:42467013 NAGA 0.79 12.05 0.59 5.98e-27 Schizophrenia; CESC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg11494091 chr17:61959527 GH2 0.73 12.66 0.61 4.86e-29 Prudent dietary pattern; CESC cis rs3820928 0.874 rs1917127 chr2:227895125 A/G cg05526886 chr2:227700861 RHBDD1 -0.45 -5.73 -0.33 2.72e-8 Pulmonary function; CESC cis rs76878669 0.561 rs12794121 chr11:66126169 G/T cg18002602 chr11:66138449 SLC29A2 0.4 6.65 0.38 1.71e-10 Educational attainment (years of education); CESC cis rs208520 0.874 rs208473 chr6:66917265 G/C cg07460842 chr6:66804631 NA -0.89 -10.85 -0.55 6.35e-23 Exhaled nitric oxide output; CESC cis rs2933343 0.679 rs789254 chr3:128574593 A/G cg24203234 chr3:128598194 ACAD9 0.43 5.86 0.34 1.38e-8 IgG glycosylation; CESC cis rs7666738 0.800 rs2865988 chr4:99067807 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.96 0.34 7.81e-9 Colonoscopy-negative controls vs population controls; CESC trans rs9467711 0.606 rs9379864 chr6:26372584 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -6.89 -0.39 4.1e-11 Autism spectrum disorder or schizophrenia; CESC cis rs854765 0.583 rs4925129 chr17:17807186 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 7.81 0.43 1.33e-13 Total body bone mineral density; CESC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg14196790 chr5:131705035 SLC22A5 0.35 5.34 0.31 2.03e-7 Breast cancer;Mosquito bite size; CESC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg00149659 chr3:10157352 C3orf10 0.72 8.61 0.47 6.41e-16 Alzheimer's disease; CESC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.07 0.3 7.31e-7 Bipolar disorder; CESC cis rs10887741 0.546 rs4316430 chr10:89443649 G/A cg13926569 chr10:89418898 PAPSS2 0.45 6.91 0.39 3.67e-11 Exercise (leisure time); CESC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg17971929 chr21:40555470 PSMG1 1.07 16.74 0.72 2.15e-43 Cognitive function; CESC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg07930192 chr7:1003750 NA 0.41 5.47 0.32 1.03e-7 Longevity;Endometriosis; CESC cis rs6542838 0.641 rs4851176 chr2:99534859 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -5.95 -0.34 8.33e-9 Fear of minor pain; CESC cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg05347473 chr6:146136440 FBXO30 -0.55 -7.0 -0.39 2.13e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg25427524 chr10:38739819 LOC399744 -0.73 -10.95 -0.56 2.97e-23 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12226046 chr10:91403655 PANK1 -0.62 -7.29 -0.41 3.65e-12 Gut microbiome composition (summer); CESC cis rs2733201 1.000 rs4419034 chr15:44348400 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.51 -5.55 -0.32 6.84e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs62064224 0.658 rs62065460 chr17:30715007 A/G cg25809561 chr17:30822961 MYO1D 0.59 8.31 0.45 5.15e-15 Schizophrenia; CESC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg22442454 chr1:209979470 IRF6 0.48 5.67 0.33 3.66e-8 Cleft lip with or without cleft palate; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09428653 chr13:99740388 NA 0.48 6.51 0.37 3.73e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs881375 0.715 rs10985073 chr9:123643855 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.78 0.38 7.82e-11 Rheumatoid arthritis; CESC cis rs11031096 0.678 rs17284356 chr11:4189232 G/C cg18678763 chr11:4115507 RRM1 -0.4 -5.18 -0.3 4.46e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11787367 chr19:38865418 PSMD8 0.6 7.25 0.41 4.55e-12 Gut microbiome composition (summer); CESC cis rs9487051 0.735 rs1260595 chr6:109519873 T/G cg01475377 chr6:109611718 NA -0.37 -5.55 -0.32 6.99e-8 Reticulocyte fraction of red cells; CESC cis rs6714016 0.744 rs2551347 chr2:23912401 C/T cg20701182 chr2:24300061 SF3B14 -0.55 -6.29 -0.36 1.3e-9 Plateletcrit; CESC cis rs9894429 0.646 rs12603868 chr17:79618834 G/C cg18240062 chr17:79603768 NPLOC4 0.48 6.22 0.36 1.89e-9 Eye color traits; CESC cis rs7267979 0.966 rs3002698 chr20:25303379 C/G cg08601574 chr20:25228251 PYGB -0.37 -5.24 -0.31 3.3e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs9486719 1.000 rs11152968 chr6:96908653 A/G cg18709589 chr6:96969512 KIAA0776 0.54 5.9 0.34 1.11e-8 Migraine;Coronary artery disease; CESC cis rs3092073 0.624 rs7275164 chr20:44604822 G/A cg00125455 chr20:44574271 PCIF1 0.38 5.97 0.34 7.46e-9 Intelligence (multi-trait analysis); CESC cis rs7818688 0.697 rs74861094 chr8:95981385 A/G cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs11785400 1.000 rs13265663 chr8:143732255 A/C cg24634471 chr8:143751801 JRK 0.45 5.87 0.34 1.28e-8 Schizophrenia; CESC cis rs7089973 0.604 rs765173 chr10:116601675 C/T cg03647239 chr10:116582469 FAM160B1 0.46 6.02 0.35 5.91e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs3820928 0.845 rs13419076 chr2:227873028 A/G cg05526886 chr2:227700861 RHBDD1 -0.44 -5.49 -0.32 9.38e-8 Pulmonary function; CESC trans rs7819412 0.775 rs2001329 chr8:10986859 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -6.44 -0.37 5.66e-10 Triglycerides; CESC cis rs28489187 0.706 rs233074 chr1:85809065 T/C cg16011679 chr1:85725395 C1orf52 0.55 6.29 0.36 1.31e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg22920501 chr2:26401640 FAM59B -0.52 -5.96 -0.34 8.06e-9 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08252533 chr2:238875575 UBE2F -0.41 -6.16 -0.35 2.65e-9 Gambling; CESC cis rs7520050 0.898 rs785502 chr1:46581444 T/C cg03146154 chr1:46216737 IPP -0.43 -5.57 -0.32 6.33e-8 Red blood cell count;Reticulocyte count; CESC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg22433210 chr17:43662623 NA 0.97 11.31 0.57 1.89e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12320322 chr11:63439260 ATL3 0.55 6.35 0.36 9.24e-10 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09909877 chr22:38203717 GCAT -0.46 -6.36 -0.36 8.84e-10 Asthma; CESC cis rs6032067 0.641 rs34622539 chr20:43756548 A/T cg10761708 chr20:43804764 PI3 0.49 5.27 0.31 2.77e-7 Blood protein levels; CESC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg19592336 chr6:28129416 ZNF389 0.62 8.14 0.45 1.55e-14 Depression; CESC cis rs6815814 0.731 rs4504265 chr4:38773865 G/T cg02016764 chr4:38805732 TLR1 -0.44 -6.08 -0.35 4.24e-9 Breast cancer; CESC trans rs4132699 0.566 rs13292725 chr9:92061948 C/G cg23619769 chr11:71952356 PHOX2A 0.42 5.99 0.35 6.71e-9 Orofacial clefts;Nonsyndromic cleft lip with or without cleft palate; CESC cis rs4654899 0.802 rs9651021 chr1:21222770 A/C cg05370193 chr1:21551575 ECE1 0.38 5.64 0.33 4.32e-8 Superior frontal gyrus grey matter volume; CESC cis rs6714710 0.580 rs13032265 chr2:98409565 T/C cg26665480 chr2:98280029 ACTR1B 0.56 7.92 0.44 6.75e-14 Posterior cortical atrophy and Alzheimer's disease; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg02536620 chr8:413240 FBXO25 -0.43 -6.16 -0.35 2.64e-9 Recombination measurement; CESC cis rs4253772 0.513 rs6008612 chr22:46707907 G/A cg24881330 chr22:46731750 TRMU 0.94 10.37 0.54 2.3e-21 LDL cholesterol;Cholesterol, total; CESC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 12.02 0.59 7.59e-27 Platelet count; CESC cis rs1322639 0.614 rs6937001 chr6:169565086 C/T cg03254818 chr6:169586852 NA -0.47 -5.42 -0.32 1.34e-7 Pulse pressure; CESC cis rs1927790 0.727 rs7996549 chr13:96975175 T/G cg02571835 chr13:96230311 CLDN10 -0.37 -5.3 -0.31 2.4e-7 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13510114 chr14:64971263 ZBTB25;ZBTB1 0.56 6.41 0.37 6.62e-10 Gut microbiome composition (summer); CESC cis rs6728642 0.519 rs62152905 chr2:97572222 C/T cg26665480 chr2:98280029 ACTR1B -0.58 -5.28 -0.31 2.75e-7 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs4713675 0.584 rs3227 chr6:33662295 G/C cg14003231 chr6:33640908 ITPR3 0.33 5.69 0.33 3.35e-8 Plateletcrit; CESC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC cis rs7267979 1.000 rs2257988 chr20:25270003 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg01017244 chr2:74357527 NA 0.68 9.78 0.51 1.75e-19 Gestational age at birth (maternal effect); CESC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg26338869 chr17:61819248 STRADA 0.68 8.93 0.48 7.3e-17 Prudent dietary pattern; CESC cis rs9926296 0.632 rs9935559 chr16:89800529 C/T cg03388025 chr16:89894329 SPIRE2 -0.3 -5.09 -0.3 6.64e-7 Vitiligo; CESC trans rs6600671 1.000 rs1832558 chr1:121177380 A/G cg17023122 chr1:144479586 NA 0.45 6.25 0.36 1.63e-9 Hip geometry; CESC cis rs17666538 0.585 rs10090260 chr8:608034 T/C cg02524346 chr8:600233 NA 0.89 6.81 0.39 6.35e-11 IgG glycosylation; CESC cis rs12410462 0.681 rs76191945 chr1:227673919 A/G cg04117972 chr1:227635322 NA 0.79 6.75 0.38 9.16e-11 Major depressive disorder; CESC cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg24110177 chr3:50126178 RBM5 0.55 7.59 0.42 5.6e-13 Body mass index; CESC cis rs7264396 0.563 rs2425081 chr20:34299733 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.7 0.38 1.23e-10 Total cholesterol levels; CESC cis rs6540556 0.769 rs6540552 chr1:209927710 C/T cg23920097 chr1:209922102 NA 0.36 5.05 0.3 8.21e-7 Red blood cell count; CESC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg26343298 chr8:95960752 TP53INP1 0.36 5.91 0.34 1.06e-8 Type 2 diabetes; CESC cis rs1865721 0.771 rs72975985 chr18:73127648 C/T cg26385618 chr18:73139727 C18orf62 -0.52 -8.29 -0.45 5.91e-15 Intelligence; CESC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg04944784 chr2:26401820 FAM59B -0.8 -8.93 -0.48 7.17e-17 Gut microbiome composition (summer); CESC cis rs826838 1.000 rs1684395 chr12:39083161 T/G cg26384229 chr12:38710491 ALG10B -0.62 -9.95 -0.52 5e-20 Heart rate; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14838070 chr5:150030486 SYNPO -0.47 -6.35 -0.36 9.5e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg26897989 chr16:1907736 C16orf73 0.5 6.04 0.35 5.22e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs7223966 0.921 rs6504186 chr17:61863932 G/A cg11494091 chr17:61959527 GH2 0.38 5.17 0.3 4.56e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7100689 0.646 rs4468295 chr10:82119276 C/G cg00277334 chr10:82204260 NA -0.59 -7.86 -0.43 9.6e-14 Post bronchodilator FEV1; CESC cis rs5758659 0.594 rs739292 chr22:42368857 G/A cg15557168 chr22:42548783 NA -0.42 -6.12 -0.35 3.37e-9 Cognitive function; CESC cis rs9325144 0.505 rs10785560 chr12:38636622 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.58 0.37 2.56e-10 Morning vs. evening chronotype; CESC cis rs3796619 0.503 rs13147452 chr4:1078124 G/A cg27284194 chr4:1044797 NA 0.59 9.64 0.51 4.71e-19 Recombination rate (males); CESC cis rs4700695 0.668 rs20768 chr5:65484805 C/T cg21114390 chr5:65439923 SFRS12 -0.47 -5.71 -0.33 3.1e-8 Facial morphology (factor 19); CESC cis rs7666738 0.830 rs34070283 chr4:98893027 A/T cg05340658 chr4:99064831 C4orf37 0.75 11.14 0.56 6.81e-24 Colonoscopy-negative controls vs population controls; CESC cis rs662064 0.962 rs2506901 chr1:10563492 A/G cg20482658 chr1:10539492 PEX14 0.36 7.29 0.41 3.52e-12 Asthma; CESC cis rs7927592 0.956 rs11228251 chr11:68244558 G/T cg16797656 chr11:68205561 LRP5 0.42 6.29 0.36 1.32e-9 Total body bone mineral density; CESC trans rs1814175 0.645 rs28538913 chr11:50040718 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.71 -0.75 2.23e-50 Height; CESC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg07343612 chr16:622815 PIGQ -0.53 -7.87 -0.44 8.81e-14 Height; CESC cis rs10751667 0.961 rs10902263 chr11:992691 A/C cg06064525 chr11:970664 AP2A2 0.4 6.32 0.36 1.1e-9 Alzheimer's disease (late onset); CESC cis rs1707322 1.000 rs1768818 chr1:46514286 G/C cg06784218 chr1:46089804 CCDC17 -0.33 -5.65 -0.33 4.08e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 1.000 rs35396113 chr7:65495461 C/T cg12463550 chr7:65579703 CRCP 0.68 5.46 0.32 1.09e-7 Diabetic kidney disease; CESC cis rs3820928 0.874 rs4234066 chr2:227882180 G/A cg05526886 chr2:227700861 RHBDD1 -0.43 -5.48 -0.32 9.75e-8 Pulmonary function; CESC cis rs1348850 0.918 rs12622298 chr2:178450651 C/T cg23306229 chr2:178417860 TTC30B 0.53 6.88 0.39 4.2e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8060686 0.516 rs7206792 chr16:68168200 C/G cg26727032 chr16:67993705 SLC12A4 -0.55 -7.65 -0.43 3.84e-13 HDL cholesterol;Metabolic syndrome; CESC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg23708337 chr7:1209742 NA 0.52 5.19 0.3 4.12e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10463316 0.894 rs7712569 chr5:150766089 A/C cg03212797 chr5:150827313 SLC36A1 -0.47 -6.22 -0.36 1.93e-9 Metabolite levels (Pyroglutamine); CESC cis rs17881320 0.510 rs6503699 chr17:40554261 C/G cg05878104 chr17:40932452 WNK4 0.48 5.2 0.3 4.01e-7 Atopic dermatitis; CESC cis rs1552244 0.554 rs2272121 chr3:10047680 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -7.26 -0.41 4.31e-12 Alzheimer's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14685339 chr14:77787351 POMT2;GSTZ1 -0.47 -6.71 -0.38 1.15e-10 Gambling; CESC cis rs7659604 0.502 rs10013916 chr4:122702179 T/G cg19748678 chr4:122722346 EXOSC9 -0.43 -5.42 -0.32 1.35e-7 Type 2 diabetes; CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg24503407 chr1:205819492 PM20D1 -0.69 -11.76 -0.59 5.76e-26 Monocyte percentage of white cells; CESC cis rs10899021 1.000 rs11236186 chr11:74362865 G/A cg25880958 chr11:74394337 NA -0.73 -7.19 -0.4 6.53e-12 Response to metformin (IC50); CESC cis rs73206853 0.686 rs60439011 chr12:110909179 T/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.59 0.32 5.78e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7772486 0.743 rs111332144 chr6:146056681 C/T cg05347473 chr6:146136440 FBXO30 -0.41 -5.57 -0.32 6.26e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg18512352 chr11:47633146 NA 0.44 6.35 0.36 9.06e-10 Subjective well-being; CESC cis rs1609391 0.543 rs9881139 chr3:136634040 A/G cg15507776 chr3:136538369 TMEM22 0.83 12.09 0.6 4.41e-27 Neuroticism; CESC cis rs17608059 0.566 rs5005684 chr17:13910633 T/C cg11395062 chr17:14139857 CDRT15 0.45 5.57 0.32 6.12e-8 Temperament; CESC cis rs7520050 0.966 rs4376778 chr1:46288846 C/G cg24296786 chr1:45957014 TESK2 0.42 5.39 0.31 1.6e-7 Red blood cell count;Reticulocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05162533 chr17:74137399 FOXJ1 0.46 6.41 0.37 6.65e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1707322 1.000 rs785484 chr1:46574015 T/C cg03146154 chr1:46216737 IPP -0.74 -9.64 -0.51 4.75e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7246657 0.943 rs4803229 chr19:37864682 T/G cg24637308 chr11:6592297 DNHD1 0.53 6.17 0.35 2.55e-9 Coronary artery calcification; CESC cis rs2228479 0.850 rs11642010 chr16:89845111 T/C cg06558623 chr16:89946397 TCF25 1.04 7.44 0.42 1.39e-12 Skin colour saturation; CESC cis rs965469 1.000 rs2236098 chr20:3267133 A/G cg25506879 chr20:3388711 C20orf194 -0.55 -5.96 -0.34 7.97e-9 IFN-related cytopenia; CESC cis rs67478160 0.643 rs34813623 chr14:104263294 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.08 -0.4 1.26e-11 Schizophrenia; CESC cis rs9902453 0.967 rs11080121 chr17:28528842 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.61 0.42 4.87e-13 Coffee consumption (cups per day); CESC cis rs13102973 0.931 rs13128765 chr4:135888141 A/G cg14419869 chr4:135874104 NA 0.34 5.39 0.31 1.54e-7 Subjective well-being; CESC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg19622623 chr12:86230825 RASSF9 -0.47 -5.95 -0.34 8.28e-9 Major depressive disorder; CESC cis rs10493773 0.532 rs12064199 chr1:86187073 A/T cg17807903 chr1:86174739 ZNHIT6 -0.41 -6.14 -0.35 2.97e-9 Urate levels in overweight individuals; CESC cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg07636037 chr3:49044803 WDR6 -1.03 -19.47 -0.77 4.91e-53 Parkinson's disease; CESC cis rs7940866 0.774 rs12420126 chr11:130834811 C/T cg12179176 chr11:130786555 SNX19 0.68 10.29 0.53 4.19e-21 Schizophrenia; CESC cis rs9399137 0.507 rs13064 chr6:135287533 A/G cg22676075 chr6:135203613 NA 0.53 7.0 0.39 2.14e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs4129059 0.831 rs72759615 chr1:214677827 G/A cg08821431 chr12:34491090 NA 0.59 6.5 0.37 4.05e-10 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg08859206 chr1:53392774 SCP2 0.61 9.01 0.48 4.28e-17 Monocyte count; CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg16145915 chr7:1198662 ZFAND2A -0.71 -11.38 -0.57 1.11e-24 Longevity;Endometriosis; CESC cis rs6570726 0.791 rs441290 chr6:145883183 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.45 0.37 5.43e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2204008 0.678 rs61929520 chr12:38446800 T/C cg26384229 chr12:38710491 ALG10B -0.44 -5.95 -0.34 8.4e-9 Bladder cancer; CESC cis rs62005083 1.000 rs62005113 chr14:74521914 C/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.7 5.22 0.31 3.68e-7 Mean corpuscular volume; CESC cis rs6088580 0.634 rs2424992 chr20:33012060 C/T cg06115741 chr20:33292138 TP53INP2 0.48 6.13 0.35 3.2e-9 Glomerular filtration rate (creatinine); CESC cis rs2235642 0.826 rs8053605 chr16:1594158 G/A cg09080909 chr16:1797204 MAPK8IP3 -0.37 -5.12 -0.3 5.84e-7 Coronary artery disease; CESC cis rs938554 0.571 rs4144 chr4:10016322 T/C cg00071950 chr4:10020882 SLC2A9 0.7 8.3 0.45 5.48e-15 Blood metabolite levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05001908 chr7:128045859 IMPDH1 -0.46 -6.09 -0.35 3.96e-9 Ulcerative colitis; CESC cis rs4319547 0.737 rs11058226 chr12:122938958 A/G cg05707623 chr12:122985044 ZCCHC8 -0.51 -6.21 -0.36 2.07e-9 Body mass index; CESC cis rs710216 0.763 rs9438964 chr1:43443742 C/T cg03128534 chr1:43423976 SLC2A1 0.46 5.03 0.3 9.19e-7 Red cell distribution width; CESC cis rs7177699 0.550 rs4468572 chr15:79124475 C/T cg04896959 chr15:78267971 NA 0.32 5.28 0.31 2.76e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs8017423 0.967 rs7146640 chr14:90720114 C/T cg14092571 chr14:90743983 NA 0.53 7.87 0.44 9.2e-14 Mortality in heart failure; CESC cis rs938554 0.513 rs3733588 chr4:9997303 A/G cg11266682 chr4:10021025 SLC2A9 -0.43 -6.31 -0.36 1.17e-9 Blood metabolite levels; CESC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg17372223 chr3:52568218 NT5DC2 0.45 6.7 0.38 1.25e-10 Bipolar disorder; CESC cis rs7539624 0.947 rs2040103 chr1:223901742 G/A cg10100437 chr1:223903862 CAPN2 -0.4 -5.97 -0.34 7.49e-9 Schizophrenia; CESC cis rs9457247 0.967 rs1211447 chr6:167381979 C/T cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.76e-8 Crohn's disease; CESC cis rs7635838 1.000 rs7635838 chr3:11412604 A/G cg00170343 chr3:11313890 ATG7 0.38 5.07 0.3 7.41e-7 HDL cholesterol; CESC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg06873352 chr17:61820015 STRADA 0.71 12.15 0.6 2.69e-27 Prudent dietary pattern; CESC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg26335602 chr6:28129616 ZNF389 -0.5 -6.55 -0.37 2.98e-10 Parkinson's disease; CESC cis rs6088580 0.634 rs6087588 chr20:33066369 T/C cg08999081 chr20:33150536 PIGU 0.66 11.67 0.58 1.11e-25 Glomerular filtration rate (creatinine); CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg03188948 chr7:1209495 NA 0.59 6.77 0.38 8.31e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11976180 0.517 rs6949375 chr7:143773851 T/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.66 -7.04 -0.4 1.64e-11 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19683457 chr6:105307726 HACE1 0.55 6.32 0.36 1.11e-9 Gut microbiome composition (summer); CESC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.64 0.33 4.45e-8 Menopause (age at onset); CESC cis rs7208859 0.623 rs11658022 chr17:29085359 A/T cg13385521 chr17:29058706 SUZ12P 0.85 6.63 0.38 1.86e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs76917914 0.820 rs58427887 chr9:100820671 C/T cg03040243 chr9:100819229 NANS 0.5 5.6 0.33 5.33e-8 Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05881034 chr3:42623675 SEC22C 0.59 6.48 0.37 4.41e-10 Gut microbiome composition (summer); CESC cis rs6120849 0.707 rs752075 chr20:33591591 C/A cg24642439 chr20:33292090 TP53INP2 0.67 6.62 0.38 1.94e-10 Protein C levels; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg09060823 chr12:56862504 SPRYD4 -0.57 -6.49 -0.37 4.29e-10 Lung cancer in ever smokers; CESC cis rs10461617 0.541 rs7715822 chr5:56043600 G/T cg18230493 chr5:56204884 C5orf35 -0.57 -5.15 -0.3 5.13e-7 Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13415434 chr3:49044522 P4HTM;WDR6 -0.5 -7.35 -0.41 2.52e-12 Gambling; CESC cis rs9875589 0.957 rs35485647 chr3:13937937 G/C cg19554555 chr3:13937349 NA 0.54 6.89 0.39 4.01e-11 Ovarian reserve; CESC cis rs1218582 0.600 rs72702224 chr1:154911689 G/A cg16680214 chr1:154839983 KCNN3 -0.46 -6.89 -0.39 3.94e-11 Prostate cancer; CESC cis rs6502050 0.835 rs3924781 chr17:80113130 T/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.33 -0.31 2.08e-7 Life satisfaction; CESC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg02462569 chr6:150064036 NUP43 -0.35 -5.19 -0.3 4.2e-7 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15414828 chr11:71791511 LRTOMT;NUMA1 0.6 7.23 0.41 5.13e-12 Gut microbiome composition (summer); CESC cis rs7179456 0.547 rs653765 chr15:59042012 T/C cg05156742 chr15:59063176 FAM63B 0.58 7.33 0.41 2.71e-12 Asperger disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19859335 chr2:70142152 MXD1 0.48 6.16 0.35 2.71e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13171016 chr1:40219054 PPIE -0.46 -6.33 -0.36 1.02e-9 Gut microbiota (bacterial taxa); CESC cis rs3733585 0.683 rs13112015 chr4:9933796 C/T cg11266682 chr4:10021025 SLC2A9 -0.55 -10.65 -0.55 2.8e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2204008 0.502 rs2387275 chr12:38142836 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.51 0.37 3.72e-10 Bladder cancer; CESC cis rs8114671 0.804 rs6088666 chr20:33564570 A/G cg07148914 chr20:33460835 GGT7 0.42 5.44 0.32 1.18e-7 Height; CESC cis rs2710642 0.525 rs1601673 chr2:62842559 G/C cg17519650 chr2:63277830 OTX1 0.5 6.66 0.38 1.57e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs9911578 0.934 rs58092632 chr17:57111101 T/C cg12560992 chr17:57184187 TRIM37 -1.01 -17.65 -0.74 1.26e-46 Intelligence (multi-trait analysis); CESC cis rs4268898 0.552 rs6754391 chr2:24369019 C/T cg06627628 chr2:24431161 ITSN2 -0.59 -8.21 -0.45 9.9e-15 Asthma; CESC cis rs4727027 0.704 rs1123992 chr7:148907201 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.03 0.3 9.1e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2249625 1.000 rs2463717 chr6:72921806 C/A cg18830697 chr6:72922368 RIMS1 -0.43 -6.15 -0.35 2.8e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06938235 chr12:56498303 PA2G4 0.58 6.35 0.36 9.12e-10 Gut microbiome composition (summer); CESC cis rs72627123 0.867 rs73303116 chr14:74483615 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.82 0.34 1.74e-8 Morning vs. evening chronotype; CESC cis rs6991838 0.584 rs7835313 chr8:66546126 C/G cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs72945132 0.882 rs4567496 chr11:70193208 A/T cg14191688 chr11:70257035 CTTN 0.47 5.57 0.32 6.1e-8 Coronary artery disease; CESC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg10800226 chr5:1850261 NA 0.36 5.9 0.34 1.11e-8 Cardiovascular disease risk factors; CESC cis rs6032067 0.632 rs35632684 chr20:43802889 C/T cg11264863 chr20:43835661 SEMG1 0.5 5.38 0.31 1.62e-7 Blood protein levels; CESC cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.49 8.55 0.47 9.9e-16 Monocyte percentage of white cells; CESC cis rs4950322 0.570 rs72691090 chr1:146769569 T/C cg16700924 chr1:146552102 NA -0.41 -5.06 -0.3 7.82e-7 Protein quantitative trait loci; CESC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg22535103 chr8:58192502 C8orf71 -0.92 -10.16 -0.53 1.04e-20 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.754 rs66900435 chr4:120249425 C/A cg09307838 chr4:120376055 NA 0.77 10.45 0.54 1.22e-21 Corneal astigmatism; CESC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg05368731 chr17:41323189 NBR1 0.61 8.34 0.46 4.03e-15 Menopause (age at onset); CESC cis rs11166927 0.870 rs11166930 chr8:140824621 A/G cg16909799 chr8:140841666 TRAPPC9 -0.5 -7.24 -0.41 4.9e-12 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg20243544 chr17:37824526 PNMT 0.46 5.75 0.33 2.52e-8 Glomerular filtration rate (creatinine); CESC cis rs1348850 0.561 rs1838890 chr2:178410938 C/A cg22681709 chr2:178499509 PDE11A -0.5 -5.3 -0.31 2.44e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs13242816 1.000 rs17138747 chr7:116132670 G/A cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC cis rs35110281 0.627 rs11701746 chr21:44975137 C/T cg01579765 chr21:45077557 HSF2BP -0.51 -8.55 -0.46 1e-15 Mean corpuscular volume; CESC trans rs1728785 0.688 rs7203363 chr16:68587692 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.83 0.43 1.2e-13 Ulcerative colitis; CESC cis rs75477785 0.590 rs4844937 chr1:210176904 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.23 0.36 1.82e-9 Cleft lip with or without cleft palate; CESC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg05604112 chr2:38893237 GALM -0.51 -6.68 -0.38 1.38e-10 5-HTT brain serotonin transporter levels; CESC cis rs10540 1.000 rs10540 chr11:494662 G/A cg03576123 chr11:487126 PTDSS2 -1.12 -11.17 -0.57 5.31e-24 Body mass index; CESC cis rs2425143 0.730 rs6060624 chr20:34413663 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.91 0.34 1.03e-8 Blood protein levels; CESC cis rs6696846 0.765 rs2836 chr1:205111761 G/T cg00857998 chr1:205179979 DSTYK -0.51 -6.63 -0.38 1.92e-10 Red blood cell count; CESC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg17724175 chr1:150552817 MCL1 0.38 5.9 0.34 1.13e-8 Melanoma; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg18755698 chr11:134046415 NCAPD3 -0.43 -6.08 -0.35 4.17e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6460942 0.591 rs62448733 chr7:12350526 C/T cg06484146 chr7:12443880 VWDE -0.65 -7.09 -0.4 1.2e-11 Coronary artery disease; CESC trans rs10411161 0.702 rs7251929 chr19:52389258 C/T cg22319618 chr22:45562946 NUP50 -0.75 -7.55 -0.42 7.24e-13 Breast cancer; CESC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg13114125 chr14:105738426 BRF1 -0.75 -9.72 -0.51 2.62e-19 Mean platelet volume;Platelet distribution width; CESC cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg18357645 chr12:58087776 OS9 -0.43 -5.94 -0.34 9.06e-9 Multiple sclerosis; CESC cis rs1707322 0.717 rs1547925 chr1:46085356 C/T cg05343316 chr1:45956843 TESK2 -0.49 -6.14 -0.35 2.99e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9443189 0.865 rs2748940 chr6:76434027 C/T cg01950844 chr6:76311363 SENP6 -0.58 -6.49 -0.37 4.31e-10 Prostate cancer; CESC cis rs4727027 0.833 rs2107846 chr7:148832774 G/A cg23583168 chr7:148888333 NA -0.78 -11.97 -0.59 1.08e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6502050 0.761 rs62078754 chr17:80058666 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.38 0.36 7.88e-10 Life satisfaction; CESC cis rs6456156 0.586 rs911632 chr6:167471461 T/C cg23791538 chr6:167370224 RNASET2 -0.5 -6.47 -0.37 4.66e-10 Primary biliary cholangitis; CESC cis rs1950626 0.716 rs34158896 chr14:101447373 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.82 11.17 0.57 5.57e-24 Pelvic organ prolapse (moderate/severe); CESC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg24642844 chr7:1081250 C7orf50 -0.76 -9.26 -0.49 7.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2880765 0.677 rs7181410 chr15:86006335 A/G cg10818794 chr15:86012489 AKAP13 0.34 5.27 0.31 2.83e-7 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06943149 chr12:77157476 ZDHHC17 -0.42 -6.28 -0.36 1.4e-9 Gambling; CESC cis rs17376456 0.825 rs12716453 chr5:93271697 T/C cg25358565 chr5:93447407 FAM172A 1.12 10.4 0.54 1.88e-21 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04510639 chr17:74722764 JMJD6;C17orf95 0.57 6.6 0.38 2.26e-10 Gut microbiome composition (summer); CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg26100137 chr18:77203667 NFATC1 -0.4 -6.04 -0.35 5.16e-9 Post-traumatic stress disorder; CESC cis rs7953508 0.506 rs2200160 chr12:93963873 C/T cg18151635 chr12:93972918 NA -0.44 -5.89 -0.34 1.19e-8 Pubertal anthropometrics; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12241299 chr14:20929705 TMEM55B -0.45 -6.12 -0.35 3.34e-9 Asthma; CESC cis rs17039065 0.920 rs11737760 chr4:109441230 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.67 6.4 0.37 7.14e-10 Gut microbiome composition (summer); CESC cis rs7927592 0.956 rs12271290 chr11:68326236 A/G cg20283391 chr11:68216788 NA 0.49 6.01 0.35 6.22e-9 Total body bone mineral density; CESC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg06636001 chr8:8085503 FLJ10661 0.44 5.71 0.33 3e-8 Mood instability; CESC cis rs7953249 0.594 rs11065384 chr12:121423285 T/C cg02403541 chr12:121454288 C12orf43 -0.65 -8.68 -0.47 4.12e-16 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs4889855 0.556 rs4278795 chr17:78533189 A/T cg16591659 chr17:78472290 NA 0.39 6.6 0.38 2.28e-10 Fractional excretion of uric acid; CESC cis rs6867032 0.527 rs13162781 chr5:2012235 C/T cg26168224 chr5:2018326 NA 0.73 12.54 0.61 1.28e-28 Gut microbiome composition (winter); CESC trans rs561341 1.000 rs521919 chr17:30298039 G/T cg20587970 chr11:113659929 NA -1.14 -14.35 -0.66 6.11e-35 Hip circumference adjusted for BMI; CESC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -10.93 -0.56 3.43e-23 Extrinsic epigenetic age acceleration; CESC cis rs3741151 1.000 rs112840535 chr11:73066771 G/A cg17517138 chr11:73019481 ARHGEF17 0.96 6.55 0.37 3e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs10197940 0.662 rs10173699 chr2:152281561 C/G cg19508488 chr2:152266495 RIF1 -0.49 -5.35 -0.31 1.92e-7 Lung cancer; CESC cis rs3008870 1.000 rs2009319 chr1:67481070 G/T cg08660285 chr1:67390436 MIER1;WDR78 1.03 14.0 0.65 1e-33 Lymphocyte percentage of white cells; CESC cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg17279839 chr7:150038598 RARRES2 -0.42 -5.5 -0.32 9.1e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.53 -0.54 7e-22 Alzheimer's disease; CESC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg18305652 chr10:134549665 INPP5A 0.49 6.91 0.39 3.58e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg12463550 chr7:65579703 CRCP 0.51 6.36 0.36 8.66e-10 Aortic root size; CESC cis rs1046896 0.731 rs8067667 chr17:80785875 A/G cg02711726 chr17:80685570 FN3KRP -0.39 -5.05 -0.3 8.21e-7 Glycated hemoglobin levels; CESC cis rs1707322 0.721 rs11211149 chr1:46112218 T/C cg03146154 chr1:46216737 IPP 0.82 11.48 0.58 5.01e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg25036284 chr2:26402008 FAM59B -0.59 -6.77 -0.38 8.41e-11 Gut microbiome composition (summer); CESC cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg23978390 chr7:1156363 C7orf50 0.67 6.54 0.37 3.07e-10 Bronchopulmonary dysplasia; CESC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg25036284 chr2:26402008 FAM59B -0.57 -6.51 -0.37 3.81e-10 Gut microbiome composition (summer); CESC cis rs7264396 0.515 rs2425134 chr20:34339439 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.6 6.68 0.38 1.41e-10 Total cholesterol levels; CESC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg04944784 chr2:26401820 FAM59B -0.66 -7.58 -0.42 5.83e-13 Gut microbiome composition (summer); CESC cis rs7086627 0.515 rs7088877 chr10:82208860 C/G cg00277334 chr10:82204260 NA -0.91 -15.92 -0.7 1.67e-40 Post bronchodilator FEV1; CESC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg04414720 chr1:150670196 GOLPH3L 0.62 8.8 0.48 1.76e-16 Tonsillectomy; CESC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Parkinson's disease; CESC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg21782813 chr7:2030301 MAD1L1 0.44 6.24 0.36 1.74e-9 Bipolar disorder and schizophrenia; CESC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg03806693 chr22:41940476 POLR3H 1.18 13.87 0.65 2.9e-33 Vitiligo; CESC cis rs6582630 0.502 rs11181230 chr12:38300085 A/G cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Drug-induced liver injury (flucloxacillin); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02031769 chr6:161695303 AGPAT4 0.49 6.55 0.37 3.02e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg16606324 chr3:10149918 C3orf24 0.41 5.03 0.3 8.88e-7 Alzheimer's disease; CESC cis rs244293 0.760 rs12952166 chr17:53005586 C/T cg19360675 chr17:53046073 COX11;STXBP4 -0.44 -5.6 -0.33 5.37e-8 Menarche (age at onset); CESC cis rs758324 0.812 rs4280859 chr5:131246941 A/T cg06307176 chr5:131281290 NA -0.39 -5.25 -0.31 3.12e-7 Alzheimer's disease in APOE e4- carriers; CESC cis rs7223966 1.000 rs6504182 chr17:61823672 T/C cg11494091 chr17:61959527 GH2 0.41 5.73 0.33 2.71e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7542091 0.635 rs7550733 chr1:210044968 G/A cg09509183 chr1:209979624 IRF6 0.4 5.78 0.33 2.12e-8 Monobrow; CESC cis rs796364 0.951 rs59695400 chr2:201021325 C/T cg23649088 chr2:200775458 C2orf69 -0.53 -5.47 -0.32 1.04e-7 Schizophrenia; CESC cis rs1905108 0.510 rs12544004 chr8:49543160 T/C cg22836229 chr8:49647717 EFCAB1 0.31 5.14 0.3 5.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11122272 0.735 rs2749705 chr1:231526696 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.12 0.35 3.28e-9 Hemoglobin concentration; CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg11041457 chr3:52719354 GNL3;PBRM1 0.44 6.69 0.38 1.33e-10 Bipolar disorder; CESC cis rs66887589 0.777 rs4643791 chr4:120265619 A/G cg09307838 chr4:120376055 NA -0.56 -7.69 -0.43 2.98e-13 Diastolic blood pressure; CESC cis rs71403859 0.685 rs12444890 chr16:71636026 G/A cg08717414 chr16:71523259 ZNF19 -0.79 -6.93 -0.39 3.26e-11 Post bronchodilator FEV1; CESC cis rs6741892 0.536 rs7590835 chr2:38893950 A/G cg00359181 chr2:38893519 GALM 0.6 8.71 0.47 3.25e-16 5-HTT brain serotonin transporter levels; CESC cis rs7267979 0.966 rs6107031 chr20:25350677 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.23e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs1878931 0.543 rs1129568 chr16:3483475 G/A cg21433313 chr16:3507492 NAT15 -0.34 -5.03 -0.3 8.85e-7 Body mass index (adult); CESC cis rs6456156 0.526 rs3093025 chr6:167532731 A/G cg23791538 chr6:167370224 RNASET2 0.42 5.37 0.31 1.74e-7 Primary biliary cholangitis; CESC cis rs61776719 0.747 rs28428561 chr1:38434306 G/A cg12658694 chr1:38397304 INPP5B -0.8 -12.18 -0.6 2.15e-27 Coronary artery disease; CESC cis rs6904897 0.563 rs6569976 chr6:135224753 A/C cg24558204 chr6:135376177 HBS1L 0.56 7.6 0.42 5.16e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs2832191 0.716 rs2297252 chr21:30377104 G/A cg24692254 chr21:30365293 RNF160 1.02 18.44 0.75 2.04e-49 Dental caries; CESC cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg10556349 chr10:835070 NA 0.57 5.56 0.32 6.44e-8 Eosinophil percentage of granulocytes; CESC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg07092213 chr7:1199455 ZFAND2A -0.5 -5.93 -0.34 9.31e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2997447 0.761 rs17257107 chr1:26448447 A/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.17 0.3 4.68e-7 QRS complex (12-leadsum); CESC cis rs6840360 0.554 rs4643789 chr4:152726691 C/T cg22705602 chr4:152727874 NA -0.39 -5.66 -0.33 3.97e-8 Intelligence (multi-trait analysis); CESC cis rs9910055 0.529 rs408282 chr17:42182267 A/G cg13607699 chr17:42295918 UBTF -0.49 -6.0 -0.35 6.38e-9 Total body bone mineral density; CESC cis rs11203032 0.831 rs10887920 chr10:90924415 C/T cg16672925 chr10:90967113 CH25H 0.7 6.65 0.38 1.62e-10 Heart failure; CESC cis rs7264396 0.676 rs6060723 chr20:34549947 G/C cg17201900 chr20:34330562 RBM39 0.49 5.11 0.3 6.08e-7 Total cholesterol levels; CESC cis rs9611565 0.918 rs9611562 chr22:41760172 T/G cg06634786 chr22:41940651 POLR3H -0.65 -6.67 -0.38 1.46e-10 Vitiligo; CESC cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg04450456 chr4:17643702 FAM184B 0.36 5.06 0.3 7.87e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs72829446 0.530 rs72827503 chr17:7371268 G/T cg02795151 chr17:7402630 POLR2A 0.53 5.07 0.3 7.53e-7 Androgen levels; CESC cis rs4689388 0.890 rs13130845 chr4:6297646 A/C cg14416269 chr4:6271139 WFS1 0.46 7.62 0.42 4.6e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9916302 0.706 rs9906612 chr17:37547631 A/C cg07936489 chr17:37558343 FBXL20 0.9 9.82 0.52 1.27e-19 Glomerular filtration rate (creatinine); CESC cis rs9287719 0.967 rs12464817 chr2:10707212 A/G cg02196655 chr2:10830764 NOL10 -0.36 -5.42 -0.32 1.31e-7 Prostate cancer; CESC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg12034118 chr1:209979487 IRF6 0.42 5.12 0.3 5.96e-7 Cleft lip with or without cleft palate; CESC cis rs7267979 1.000 rs761025 chr20:25426968 G/A cg08601574 chr20:25228251 PYGB 0.38 5.57 0.32 6.24e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2070433 0.500 rs2070435 chr21:47961711 C/T cg12379764 chr21:47803548 PCNT 0.53 6.97 0.39 2.52e-11 Lymphocyte counts; CESC cis rs6964587 0.934 rs6465344 chr7:91640273 G/A cg17063962 chr7:91808500 NA 0.55 7.63 0.42 4.25e-13 Breast cancer; CESC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg21644426 chr2:191273491 MFSD6 0.48 6.31 0.36 1.17e-9 Pulse pressure; CESC cis rs4689388 0.890 rs9993624 chr4:6286528 C/T cg14416269 chr4:6271139 WFS1 0.46 7.66 0.43 3.53e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs614226 0.872 rs787827 chr12:120937794 A/G cg01236616 chr12:121019343 POP5 1.55 19.98 0.78 8.29e-55 Type 1 diabetes nephropathy; CESC cis rs10465746 0.780 rs11163867 chr1:84384847 C/T cg10977910 chr1:84465055 TTLL7 0.51 6.87 0.39 4.59e-11 Obesity-related traits; CESC cis rs7605827 0.866 rs6717492 chr2:15538171 A/G cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs854765 0.663 rs1052299 chr17:17750419 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.51 -7.12 -0.4 9.92e-12 Total body bone mineral density; CESC cis rs7520050 0.902 rs9429088 chr1:46497500 T/A cg03146154 chr1:46216737 IPP -0.47 -6.19 -0.36 2.27e-9 Red blood cell count;Reticulocyte count; CESC cis rs11577318 0.853 rs2276712 chr1:26627478 T/C cg00852783 chr1:26633632 UBXN11 0.51 6.99 0.39 2.2e-11 Granulocyte percentage of myeloid white cells; CESC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg27297192 chr10:134578999 INPP5A 0.39 5.03 0.3 9.01e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14521523 chr1:115212675 DENND2C -0.44 -6.54 -0.37 3.19e-10 Fibrinogen levels; CESC cis rs1577917 1.000 rs11758849 chr6:86708262 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -5.8 -0.34 1.87e-8 Response to antipsychotic treatment; CESC cis rs1008375 1.000 rs4698198 chr4:17656536 G/A cg02297831 chr4:17616191 MED28 0.53 6.7 0.38 1.24e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.65 0.38 1.71e-10 Prudent dietary pattern; CESC cis rs2243480 1.000 rs1796220 chr7:66062100 C/T cg13147721 chr7:65941812 NA -0.93 -8.74 -0.47 2.72e-16 Diabetic kidney disease; CESC cis rs1707322 1.000 rs1707303 chr1:46598273 A/C cg03146154 chr1:46216737 IPP -0.7 -8.81 -0.48 1.64e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7683537 0.673 rs1401363 chr4:185643862 A/G cg04058563 chr4:185651563 MLF1IP 0.65 7.16 0.4 8e-12 Systemic lupus erythematosus; CESC cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg24130564 chr14:104152367 KLC1 -0.49 -6.47 -0.37 4.74e-10 Reticulocyte count; CESC cis rs11098499 0.779 rs80242894 chr4:120375752 G/A cg09307838 chr4:120376055 NA 0.95 13.78 0.65 6.32e-33 Corneal astigmatism; CESC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.57 0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg01416388 chr22:39784598 NA -0.59 -7.58 -0.42 5.96e-13 Intelligence (multi-trait analysis); CESC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg22143856 chr6:28129313 ZNF389 0.38 5.38 0.31 1.6e-7 Cardiac Troponin-T levels; CESC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.62 -0.33 4.89e-8 Total body bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20134190 chr8:99129593 POP1;HRSP12 -0.54 -7.91 -0.44 6.9e-14 Gambling; CESC cis rs796364 0.806 rs11684895 chr2:201009026 C/T cg23649088 chr2:200775458 C2orf69 -0.55 -5.04 -0.3 8.69e-7 Schizophrenia; CESC cis rs7872515 0.536 rs7864340 chr9:94777390 T/C cg01248375 chr9:94877805 SPTLC1 0.61 5.4 0.31 1.48e-7 Bipolar disorder and schizophrenia; CESC cis rs1797885 0.816 rs2596829 chr3:12563639 T/C cg26432171 chr3:12704882 RAF1 -0.48 -6.12 -0.35 3.35e-9 Immature fraction of reticulocytes; CESC cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg22875332 chr1:76189707 ACADM -0.64 -7.42 -0.41 1.63e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs72781680 1.000 rs72796358 chr2:24160132 T/A cg08917208 chr2:24149416 ATAD2B 0.94 8.52 0.46 1.26e-15 Lymphocyte counts; CESC cis rs7561273 0.586 rs12477718 chr2:24330539 A/G cg20701182 chr2:24300061 SF3B14 0.51 6.52 0.37 3.55e-10 Quantitative traits; CESC cis rs6940638 0.688 rs9393790 chr6:27114052 A/C cg12292205 chr6:26970375 C6orf41 0.39 5.1 0.3 6.49e-7 Intelligence (multi-trait analysis); CESC trans rs61931739 0.500 rs10844829 chr12:34304916 G/T cg26384229 chr12:38710491 ALG10B 0.62 8.77 0.47 2.23e-16 Morning vs. evening chronotype; CESC cis rs763121 0.819 rs4560233 chr22:38982442 A/T cg21395723 chr22:39101663 GTPBP1 0.41 5.14 0.3 5.47e-7 Menopause (age at onset); CESC cis rs853679 0.882 rs4713139 chr6:28092685 C/T cg18032046 chr6:28092343 ZSCAN16 -0.72 -6.44 -0.37 5.75e-10 Depression; CESC cis rs6540559 0.546 rs7551944 chr1:210029430 G/C cg21951975 chr1:209979733 IRF6 0.58 6.15 0.35 2.77e-9 Cleft lip with or without cleft palate; CESC cis rs2354432 0.714 rs7531962 chr1:146746023 G/A cg25205988 chr1:146714368 CHD1L -1.03 -11.99 -0.59 9.69e-27 Mitochondrial DNA levels; CESC cis rs1559088 0.847 rs3760891 chr19:33599708 C/T cg17764715 chr19:33622953 WDR88 0.48 6.2 0.36 2.2e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs8072100 0.935 rs78737171 chr17:45668760 A/T cg08085267 chr17:45401833 C17orf57 0.4 5.15 0.3 5.18e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs67072384 0.748 rs6592484 chr11:72464470 C/T cg04827223 chr11:72435913 ARAP1 -0.7 -7.1 -0.4 1.16e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs708547 1.000 rs708547 chr4:57821309 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.7 7.59 0.42 5.56e-13 Response to bleomycin (chromatid breaks); CESC cis rs9902453 1.000 rs8065261 chr17:28418041 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.63 -7.93 -0.44 6.25e-14 Coffee consumption (cups per day); CESC trans rs853679 0.546 rs35016036 chr6:28314880 C/T cg01620082 chr3:125678407 NA -0.76 -6.21 -0.36 2.08e-9 Depression; CESC cis rs2760061 0.819 rs708111 chr1:228191365 G/A cg18477163 chr1:228402036 OBSCN 0.31 5.5 0.32 9.1e-8 Diastolic blood pressure; CESC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.47 6.83 0.39 5.85e-11 Total body bone mineral density; CESC cis rs4803468 1.000 rs284654 chr19:41928724 G/A cg09537434 chr19:41945824 ATP5SL -1.09 -20.16 -0.78 2.05e-55 Height; CESC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg11764359 chr7:65958608 NA -0.73 -10.44 -0.54 1.38e-21 Aortic root size; CESC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg24881330 chr22:46731750 TRMU 0.75 6.45 0.37 5.18e-10 LDL cholesterol;Cholesterol, total; CESC cis rs6060717 0.654 rs6058347 chr20:34483781 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.66 6.73 0.38 1.06e-10 Hip circumference adjusted for BMI; CESC cis rs17376456 0.825 rs10072232 chr5:93398890 G/A cg25358565 chr5:93447407 FAM172A 1.11 10.75 0.55 1.35e-22 Diabetic retinopathy; CESC cis rs9660992 0.674 rs17345816 chr1:205262868 A/T cg00857998 chr1:205179979 DSTYK -0.47 -5.3 -0.31 2.42e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs7726839 0.540 rs11739847 chr5:609661 G/A cg16447950 chr5:562315 NA -0.58 -5.93 -0.34 9.42e-9 Obesity-related traits; CESC cis rs2066819 1.000 rs76151170 chr12:56659320 C/T cg26734620 chr12:56694298 CS 1.03 6.76 0.38 8.6e-11 Psoriasis vulgaris; CESC cis rs11168351 1.000 rs11168351 chr12:48403765 C/T cg24011408 chr12:48396354 COL2A1 0.51 8.0 0.44 4e-14 Bipolar disorder and schizophrenia; CESC cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg11752832 chr7:134001865 SLC35B4 0.55 7.23 0.41 5.27e-12 Mean platelet volume; CESC cis rs3008870 1.000 rs2985825 chr1:67412822 T/G cg02640540 chr1:67518911 SLC35D1 0.52 5.59 0.33 5.5e-8 Lymphocyte percentage of white cells; CESC cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.87 9.04 0.49 3.35e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs763121 0.925 rs4821797 chr22:39016182 T/C cg06022373 chr22:39101656 GTPBP1 0.89 15.01 0.68 2.93e-37 Menopause (age at onset); CESC cis rs769267 0.566 rs7249692 chr19:19670688 T/C cg03709012 chr19:19516395 GATAD2A -0.68 -8.39 -0.46 2.84e-15 Tonsillectomy; CESC trans rs3780486 0.846 rs10971420 chr9:33125000 T/C cg20290983 chr6:43655470 MRPS18A 0.99 18.4 0.75 2.85e-49 IgG glycosylation; CESC cis rs225245 0.791 rs6505492 chr17:34026597 C/T cg05299278 chr17:33885742 SLFN14 0.39 5.66 0.33 3.97e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs6500395 1.000 rs11649236 chr16:48632478 C/T cg04672837 chr16:48644449 N4BP1 0.52 6.51 0.37 3.7e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.91 0.48 8.46e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs2243480 1.000 rs1553174 chr7:65731194 T/C cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs12477438 0.501 rs34272114 chr2:99737443 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 12.74 0.62 2.5e-29 Chronic sinus infection; CESC cis rs728616 0.614 rs61859196 chr10:82109048 A/G cg05935833 chr10:81318306 SFTPA2 -0.47 -5.91 -0.34 1.06e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2050392 0.965 rs2480279 chr10:30700032 C/T cg18806716 chr10:30721971 MAP3K8 -0.43 -6.22 -0.36 1.89e-9 Inflammatory bowel disease; CESC cis rs861020 1.000 rs642961 chr1:209989270 A/G cg05527609 chr1:210001259 C1orf107 1.0 12.54 0.61 1.2e-28 Orofacial clefts; CESC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg03806693 chr22:41940476 POLR3H -1.24 -16.78 -0.72 1.44e-43 Vitiligo; CESC cis rs28374715 0.578 rs13313520 chr15:41629127 T/G cg20272979 chr15:41787780 ITPKA 0.47 5.6 0.33 5.38e-8 Ulcerative colitis; CESC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg22920501 chr2:26401640 FAM59B -0.9 -10.21 -0.53 7.46e-21 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01600100 chr12:96794307 CDK17 0.58 6.2 0.36 2.21e-9 Gut microbiome composition (summer); CESC cis rs7312774 0.618 rs35435903 chr12:107346572 G/C cg16260113 chr12:107380972 MTERFD3 0.82 7.48 0.42 1.11e-12 Severe influenza A (H1N1) infection; CESC trans rs7980799 0.649 rs11052736 chr12:33669583 T/C cg26384229 chr12:38710491 ALG10B 0.58 8.14 0.45 1.5e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs2573652 0.722 rs968412 chr15:100544512 C/G cg09918751 chr15:100517450 ADAMTS17 -0.31 -5.74 -0.33 2.6e-8 Height; CESC cis rs4253772 0.637 rs3087501 chr22:46647909 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 7.77 0.43 1.74e-13 LDL cholesterol;Cholesterol, total; CESC cis rs17601876 0.814 rs749292 chr15:51558731 A/G cg19946085 chr15:51559439 CYP19A1 0.34 5.41 0.32 1.41e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs8177179 0.967 rs4994581 chr3:133437563 T/C cg24879335 chr3:133465180 TF 0.41 7.51 0.42 8.82e-13 Iron status biomarkers (transferrin levels); CESC cis rs910316 0.763 rs175047 chr14:75479039 C/G cg16144293 chr14:75469539 EIF2B2 0.4 5.36 0.31 1.77e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04953292 chr16:66835552 CCDC79 -0.61 -6.75 -0.38 9.41e-11 Gut microbiome composition (summer); CESC cis rs2688608 0.592 rs2306328 chr10:75579510 C/T cg23231163 chr10:75533350 FUT11 -0.33 -5.04 -0.3 8.53e-7 Inflammatory bowel disease; CESC cis rs13091206 1 rs13091206 chr3:49238718 A/G cg06212747 chr3:49208901 KLHDC8B 0.49 5.08 0.3 7.17e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg05234568 chr11:5960015 NA -0.62 -7.34 -0.41 2.56e-12 DNA methylation (variation); CESC cis rs9300255 0.568 rs1621194 chr12:123651018 T/C cg05973401 chr12:123451056 ABCB9 0.5 5.81 0.34 1.79e-8 Neutrophil percentage of white cells; CESC cis rs523522 0.962 rs12371550 chr12:120987643 C/T cg12219531 chr12:120966889 COQ5 0.75 9.9 0.52 7e-20 High light scatter reticulocyte count; CESC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.79 -0.55 9.74e-23 Alzheimer's disease; CESC cis rs66530629 0.874 rs9332415 chr1:25098245 T/C cg22509179 chr1:25234806 RUNX3 -0.44 -5.64 -0.33 4.27e-8 Plateletcrit; CESC cis rs9487051 0.676 rs6928622 chr6:109595112 C/T cg12927641 chr6:109611667 NA -0.37 -5.56 -0.32 6.46e-8 Reticulocyte fraction of red cells; CESC cis rs1927790 0.727 rs7320065 chr13:96937738 C/G cg02571835 chr13:96230311 CLDN10 -0.39 -5.58 -0.32 5.79e-8 Body mass index; CESC cis rs1707322 1.000 rs1622208 chr1:46498375 A/G cg05343316 chr1:45956843 TESK2 -0.5 -6.05 -0.35 4.86e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg02951883 chr7:2050386 MAD1L1 -0.51 -6.79 -0.39 7.2e-11 Bipolar disorder and schizophrenia; CESC cis rs1559088 0.649 rs4528686 chr19:33556074 A/G cg27124370 chr19:33622961 WDR88 0.43 5.5 0.32 8.75e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1018836 0.608 rs1033347 chr8:91464137 G/A cg16814680 chr8:91681699 NA -0.51 -6.98 -0.39 2.42e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs17376456 1.000 rs58734583 chr5:93532155 C/T cg25358565 chr5:93447407 FAM172A 1.18 11.77 0.59 5.27e-26 Diabetic retinopathy; CESC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg24675658 chr1:53192096 ZYG11B 0.6 7.55 0.42 7.13e-13 Monocyte count; CESC cis rs34779708 0.931 rs4934693 chr10:35271844 G/A cg03585969 chr10:35415529 CREM 0.77 10.13 0.53 1.39e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.48 6.13 0.35 3.14e-9 Tonsillectomy; CESC cis rs9513627 1.000 rs9517755 chr13:100168408 C/A cg25919922 chr13:100150906 NA 0.64 5.07 0.3 7.61e-7 Obesity-related traits; CESC cis rs9811920 0.609 rs793447 chr3:99598278 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs9467711 0.516 rs1324088 chr6:25841122 C/T cg21479132 chr6:26055353 NA 0.59 6.41 0.37 6.79e-10 Autism spectrum disorder or schizophrenia; CESC trans rs1814175 0.817 rs28594987 chr11:50045181 C/T cg03929089 chr4:120376271 NA -0.94 -15.73 -0.69 7.69e-40 Height; CESC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg00339695 chr16:24857497 SLC5A11 0.51 6.68 0.38 1.36e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs637571 0.726 rs669371 chr11:65674153 G/T cg17712092 chr4:129076599 LARP1B -0.8 -10.62 -0.55 3.62e-22 Eosinophil percentage of white cells; CESC cis rs12497850 0.863 rs4974084 chr3:48939080 G/A cg06212747 chr3:49208901 KLHDC8B 0.7 9.47 0.5 1.64e-18 Parkinson's disease; CESC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg24846343 chr22:24311635 DDTL -0.52 -8.36 -0.46 3.5e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs17039065 0.920 rs11932814 chr4:109461558 G/A cg16022748 chr4:109541635 LOC285456;RPL34 0.65 5.96 0.34 8.08e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg02725872 chr8:58115012 NA -0.42 -6.73 -0.38 1.05e-10 Developmental language disorder (linguistic errors); CESC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg25767906 chr1:53392781 SCP2 -0.46 -5.82 -0.34 1.66e-8 Monocyte count; CESC cis rs9911578 1.000 rs8076121 chr17:57041699 G/A cg12560992 chr17:57184187 TRIM37 0.92 15.24 0.68 4.34e-38 Intelligence (multi-trait analysis); CESC cis rs4889855 0.505 rs6565467 chr17:78610113 A/G cg16591659 chr17:78472290 NA -0.32 -5.17 -0.3 4.53e-7 Fractional excretion of uric acid; CESC cis rs12410462 0.792 rs994666 chr1:227651454 C/T cg04117972 chr1:227635322 NA -0.6 -5.94 -0.34 9.13e-9 Major depressive disorder; CESC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg13393036 chr8:95962371 TP53INP1 -0.5 -10.81 -0.55 8.28e-23 Type 2 diabetes; CESC cis rs921968 0.565 rs1554622 chr2:219606218 T/G cg02176678 chr2:219576539 TTLL4 -0.46 -8.13 -0.45 1.7e-14 Mean corpuscular hemoglobin concentration; CESC cis rs2425143 1.000 rs11699793 chr20:34271574 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -7.36 -0.41 2.28e-12 Blood protein levels; CESC cis rs213032 1.000 rs213032 chr1:21654735 T/C cg16416158 chr1:21652298 ECE1 0.33 5.37 0.31 1.71e-7 Obesity-related traits; CESC cis rs225245 0.755 rs6505491 chr17:34026335 A/G cg05299278 chr17:33885742 SLFN14 0.39 5.51 0.32 8.5e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs7553864 0.636 rs7543740 chr1:87609026 C/T cg17420885 chr1:87600446 LOC339524 -0.46 -6.28 -0.36 1.36e-9 Smoking behavior; CESC cis rs3125734 0.633 rs4979772 chr10:63967600 C/T cg09941381 chr10:64027924 RTKN2 0.31 5.09 0.3 6.86e-7 Rheumatoid arthritis; CESC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg12311346 chr5:56204834 C5orf35 0.64 8.57 0.47 8.86e-16 Initial pursuit acceleration; CESC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg05863683 chr7:1912471 MAD1L1 0.41 5.95 0.34 8.26e-9 Bipolar disorder and schizophrenia; CESC cis rs6088590 0.707 rs67159833 chr20:33488079 T/C cg06115741 chr20:33292138 TP53INP2 0.62 7.21 0.4 5.94e-12 Coronary artery disease; CESC cis rs11112613 0.762 rs66754070 chr12:105949779 G/A cg03607813 chr12:105948248 NA 0.68 8.35 0.46 3.94e-15 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs722599 0.847 rs2058919 chr14:75310812 C/G cg11812906 chr14:75593930 NEK9 -0.4 -5.26 -0.31 2.97e-7 IgG glycosylation; CESC cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.78e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs17253792 0.822 rs112238223 chr14:56056144 C/A cg01858014 chr14:56050164 KTN1 -0.96 -7.13 -0.4 9.72e-12 Putamen volume; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11502736 chr1:179923845 CEP350 0.47 6.47 0.37 4.73e-10 Systemic lupus erythematosus; CESC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg18230493 chr5:56204884 C5orf35 -0.74 -8.65 -0.47 4.87e-16 Initial pursuit acceleration; CESC cis rs9287719 0.556 rs10168351 chr2:10736810 T/C cg00105475 chr2:10696890 NA 0.38 5.17 0.3 4.51e-7 Prostate cancer; CESC cis rs151234 0.741 rs56236750 chr16:28594711 C/T cg01378222 chr16:28622494 SULT1A1 -0.55 -6.74 -0.38 9.63e-11 Platelet distribution width; CESC cis rs7927771 0.864 rs10838724 chr11:47527052 G/T cg18512352 chr11:47633146 NA -0.57 -8.73 -0.47 2.92e-16 Subjective well-being; CESC trans rs6818288 0.778 rs7663721 chr4:30076944 T/A cg12528397 chr3:62933670 NA 0.42 6.13 0.35 3.2e-9 Obesity-related traits; CESC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg12963246 chr6:28129442 ZNF389 -0.5 -6.93 -0.39 3.17e-11 Depression; CESC cis rs10887741 0.646 rs12413510 chr10:89436979 T/C cg13926569 chr10:89418898 PAPSS2 0.47 7.15 0.4 8.25e-12 Exercise (leisure time); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12010544 chr10:135102440 TUBGCP2 -0.47 -6.08 -0.35 4.13e-9 Gut microbiota (bacterial taxa); CESC cis rs7044106 0.791 rs10760116 chr9:123494681 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.34 5.52 0.32 8.07e-8 Hip circumference adjusted for BMI; CESC cis rs5997397 0.934 rs6005863 chr22:29156448 A/G cg15103426 chr22:29168792 CCDC117 0.49 6.33 0.36 1.05e-9 Red cell distribution width; CESC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg07092213 chr7:1199455 ZFAND2A -0.43 -5.68 -0.33 3.45e-8 Longevity;Endometriosis; CESC cis rs67478160 0.643 rs7156697 chr14:104211136 G/A cg01849466 chr14:104193079 ZFYVE21 -0.49 -6.87 -0.39 4.47e-11 Schizophrenia; CESC cis rs7927592 0.913 rs7116994 chr11:68254627 C/T cg20283391 chr11:68216788 NA -0.52 -6.36 -0.36 8.87e-10 Total body bone mineral density; CESC cis rs3767633 0.858 rs6698065 chr1:161891528 G/A cg09175582 chr1:161736000 ATF6 0.78 6.6 0.38 2.25e-10 IgG glycosylation; CESC cis rs7818345 0.904 rs6997164 chr8:19287856 G/T cg11303988 chr8:19266685 CSGALNACT1 0.38 6.73 0.38 1.04e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs7949030 0.588 rs2509982 chr11:62312318 C/T cg13298116 chr11:62369859 EML3;MTA2 0.58 8.58 0.47 8.21e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9393777 0.623 rs7756567 chr6:26481642 T/G cg14345882 chr6:26364793 BTN3A2 0.43 5.34 0.31 2.01e-7 Intelligence (multi-trait analysis); CESC cis rs870825 0.616 rs7682557 chr4:185640773 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs7520050 0.966 rs6662641 chr1:46571509 T/A cg03146154 chr1:46216737 IPP -0.43 -5.52 -0.32 8.27e-8 Red blood cell count;Reticulocyte count; CESC trans rs7726839 0.540 rs28364691 chr5:664084 G/A cg25482853 chr8:67687455 SGK3 0.97 9.73 0.51 2.43e-19 Obesity-related traits; CESC cis rs7666738 0.830 rs11944855 chr4:99068258 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.5 0.46 1.41e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18560442 chr1:39174410 NA -0.63 -7.26 -0.41 4.27e-12 Gut microbiome composition (summer); CESC cis rs2806561 0.704 rs674386 chr1:23521835 G/A cg12483005 chr1:23474871 LUZP1 0.43 6.55 0.37 2.93e-10 Height; CESC cis rs7680126 0.609 rs11723742 chr4:10111572 A/G cg00071950 chr4:10020882 SLC2A9 -0.61 -7.39 -0.41 1.98e-12 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs654950 0.807 rs61773660 chr1:41993298 C/T cg06885757 chr1:42089581 HIVEP3 -0.46 -7.18 -0.4 6.91e-12 Airway imaging phenotypes; CESC cis rs3820068 0.603 rs7537618 chr1:15977682 G/A cg18133145 chr1:16060689 PLEKHM2 -0.4 -5.09 -0.3 6.65e-7 Systolic blood pressure; CESC cis rs1707322 0.691 rs11211175 chr1:46220884 C/G cg05343316 chr1:45956843 TESK2 0.48 6.1 0.35 3.82e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7937682 0.889 rs12360825 chr11:111528786 A/T cg22437258 chr11:111473054 SIK2 0.69 9.26 0.49 7.48e-18 Primary sclerosing cholangitis; CESC cis rs34779708 0.966 rs12774834 chr10:35400070 A/T cg03585969 chr10:35415529 CREM 0.77 10.1 0.53 1.71e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg10295955 chr4:187884368 NA -1.07 -19.89 -0.77 1.66e-54 Lobe attachment (rater-scored or self-reported); CESC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg00750074 chr16:89608354 SPG7 0.44 6.43 0.37 5.77e-10 Multiple myeloma (IgH translocation); CESC cis rs9905704 0.918 rs35934668 chr17:56894638 A/G cg12560992 chr17:57184187 TRIM37 0.61 7.14 0.4 9.17e-12 Testicular germ cell tumor; CESC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.57 0.32 6.16e-8 Menopause (age at onset); CESC cis rs7208859 0.623 rs11650982 chr17:29129955 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1790761 0.587 rs4930431 chr11:67294308 C/T cg00290607 chr11:67383545 NA -0.42 -6.3 -0.36 1.24e-9 Mean corpuscular volume; CESC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC cis rs7927771 0.524 rs7101597 chr11:47797917 A/T cg18512352 chr11:47633146 NA 0.34 5.24 0.31 3.35e-7 Subjective well-being; CESC cis rs4930103 0.935 rs11042170 chr11:2021625 C/T cg23202291 chr11:1979235 NA 0.36 5.11 0.3 6.11e-7 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs3733585 0.699 rs10017674 chr4:9967053 T/C cg11266682 chr4:10021025 SLC2A9 -0.58 -10.94 -0.56 3.03e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs992157 0.710 rs12694432 chr2:219082330 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.61 0.51 5.92e-19 Colorectal cancer; CESC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg18230493 chr5:56204884 C5orf35 -0.7 -8.28 -0.45 6.03e-15 Initial pursuit acceleration; CESC cis rs12042938 0.507 rs2570408 chr1:231732934 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.5 -0.46 1.43e-15 Neuranatomic and neurocognitive phenotypes; CESC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg12463550 chr7:65579703 CRCP -0.5 -6.42 -0.37 6.3e-10 Aortic root size; CESC cis rs9443189 1.000 rs9443189 chr6:76495882 A/G cg01950844 chr6:76311363 SENP6 0.63 6.38 0.37 7.69e-10 Prostate cancer; CESC cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg23018236 chr17:30244563 NA -0.54 -5.08 -0.3 7.28e-7 Hip circumference adjusted for BMI; CESC cis rs6963495 0.818 rs73190133 chr7:105147821 G/C cg19920283 chr7:105172520 RINT1 0.66 6.28 0.36 1.36e-9 Bipolar disorder (body mass index interaction); CESC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg14926445 chr8:58193284 C8orf71 -0.53 -5.2 -0.3 3.9e-7 Developmental language disorder (linguistic errors); CESC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg10053473 chr17:62856997 LRRC37A3 0.65 8.79 0.48 1.9e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2522056 1.000 rs6874639 chr5:131778716 C/T cg24060327 chr5:131705240 SLC22A5 -0.65 -7.93 -0.44 6.05e-14 Lymphocyte counts;Fibrinogen; CESC cis rs950776 0.518 rs12591557 chr15:78811732 A/G cg06917634 chr15:78832804 PSMA4 0.78 11.39 0.57 9.64e-25 Sudden cardiac arrest; CESC cis rs10493773 0.775 rs6667672 chr1:86171072 A/G cg17807903 chr1:86174739 ZNHIT6 -0.43 -5.78 -0.33 2.06e-8 Urate levels in overweight individuals; CESC cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.18 0.3 4.42e-7 Colonoscopy-negative controls vs population controls; CESC trans rs7726839 0.574 rs72705017 chr5:623733 G/A cg25482853 chr8:67687455 SGK3 1.02 10.05 0.53 2.35e-20 Obesity-related traits; CESC cis rs7223966 1.000 rs9747164 chr17:61864787 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.09 -0.3 6.66e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg21770322 chr7:97807741 LMTK2 -0.54 -8.22 -0.45 8.89e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg14159672 chr1:205819179 PM20D1 0.77 11.58 0.58 2.27e-25 Menarche (age at onset); CESC cis rs7927592 0.956 rs10896337 chr11:68284236 T/C cg16797656 chr11:68205561 LRP5 0.38 5.3 0.31 2.48e-7 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13513270 chr19:48867481 TMEM143;SYNGR4 0.51 6.05 0.35 4.85e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09419297 chr15:77712428 HMG20A -0.62 -7.15 -0.4 8.39e-12 Gut microbiome composition (summer); CESC cis rs7000551 0.751 rs2461481 chr8:22382780 A/G cg12081754 chr8:22256438 SLC39A14 -0.43 -5.85 -0.34 1.48e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg18225595 chr11:63971243 STIP1 0.53 5.23 0.31 3.51e-7 Mean platelet volume; CESC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg20203395 chr5:56204925 C5orf35 -0.39 -5.25 -0.31 3.07e-7 Initial pursuit acceleration; CESC cis rs910316 0.591 rs7157158 chr14:75457238 A/G cg11812906 chr14:75593930 NEK9 0.78 12.23 0.6 1.38e-27 Height; CESC cis rs9512730 0.553 rs6491212 chr13:28049631 T/C cg08193333 chr13:27998609 GTF3A 0.47 5.83 0.34 1.58e-8 Schizophrenia; CESC cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg23711669 chr6:146136114 FBXO30 1.03 15.86 0.7 2.71e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs9915657 0.840 rs10512582 chr17:70139393 A/C cg09344028 chr17:70110421 NA 0.34 6.15 0.35 2.81e-9 Thyroid hormone levels; CESC cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg17414380 chr19:19431394 KIAA0892;SF4 0.49 6.19 0.36 2.33e-9 Tonsillectomy; CESC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs9611565 0.649 rs9623450 chr22:42175231 G/A cg03806693 chr22:41940476 POLR3H 0.79 9.47 0.5 1.59e-18 Vitiligo; CESC cis rs1008375 1.000 rs10805358 chr4:17652450 A/C cg02297831 chr4:17616191 MED28 0.53 6.7 0.38 1.26e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7264396 0.635 rs6060685 chr20:34512023 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.58 7.06 0.4 1.44e-11 Total cholesterol levels; CESC cis rs7937682 0.824 rs11213962 chr11:111506027 G/A cg22437258 chr11:111473054 SIK2 0.7 9.35 0.5 3.83e-18 Primary sclerosing cholangitis; CESC trans rs801193 1.000 rs11773829 chr7:66141074 G/A cg26939375 chr7:64535504 NA -0.65 -8.74 -0.47 2.7e-16 Aortic root size; CESC cis rs919433 0.783 rs2565155 chr2:198236425 A/G cg03934865 chr2:198174659 NA 0.43 6.21 0.36 2.01e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs11098499 0.954 rs17046116 chr4:120387259 G/A cg09307838 chr4:120376055 NA 0.95 13.96 0.65 1.42e-33 Corneal astigmatism; CESC cis rs2985684 0.846 rs4476096 chr14:50019391 A/C cg02151108 chr14:50098012 C14orf104 -0.38 -5.04 -0.3 8.48e-7 Carotid intima media thickness; CESC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg11905131 chr22:24372483 LOC391322 -0.72 -10.75 -0.55 1.34e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs6788895 1.000 rs16862842 chr3:150484844 A/G cg07663535 chr3:150480033 SIAH2 0.72 5.03 0.3 9.16e-7 Breast cancer; CESC cis rs863345 0.935 rs10797026 chr1:158519710 T/C cg12129480 chr1:158549410 OR10X1 -0.33 -6.56 -0.37 2.84e-10 Pneumococcal bacteremia; CESC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg06481639 chr22:41940642 POLR3H -0.62 -6.41 -0.37 6.55e-10 Vitiligo; CESC cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 8.33 0.46 4.25e-15 Platelet count; CESC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg10295955 chr4:187884368 NA -1.08 -22.82 -0.81 1.67e-64 Lobe attachment (rater-scored or self-reported); CESC cis rs7580658 0.963 rs62157555 chr2:128107176 C/T cg10021288 chr2:128175891 PROC -0.41 -6.47 -0.37 4.67e-10 Protein C levels; CESC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg12412775 chr1:25698385 RHCE -0.28 -5.08 -0.3 7.05e-7 Erythrocyte sedimentation rate; CESC cis rs9309473 0.583 rs6546822 chr2:73575098 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.43 -0.37 5.79e-10 Metabolite levels; CESC cis rs60515486 0.527 rs2254240 chr11:47357170 G/A cg25783544 chr11:47291846 MADD 0.56 6.43 0.37 6.02e-10 Lymphocyte counts; CESC cis rs7216064 0.911 rs6504551 chr17:65903326 T/G cg12091567 chr17:66097778 LOC651250 -0.66 -8.4 -0.46 2.81e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11864453 0.786 rs1050362 chr16:72130815 C/A cg01557791 chr16:72042693 DHODH -0.51 -6.59 -0.38 2.39e-10 Fibrinogen levels; CESC cis rs6120849 0.754 rs6088691 chr20:33633758 C/T cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs3916 0.641 rs2393749 chr12:121131891 C/T cg20569203 chr12:120799911 MSI1 0.31 5.17 0.3 4.54e-7 Urinary metabolites (H-NMR features); CESC cis rs6456156 0.755 rs4710182 chr6:167514061 G/A cg23791538 chr6:167370224 RNASET2 -0.4 -5.26 -0.31 2.92e-7 Primary biliary cholangitis; CESC cis rs10885582 0.781 rs10885578 chr10:116303554 G/C cg17056676 chr10:116301354 ABLIM1 -0.29 -5.31 -0.31 2.37e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs11264213 0.786 rs72659702 chr1:36317471 G/C cg27506609 chr1:36549197 TEKT2 0.57 5.08 0.3 6.98e-7 Schizophrenia; CESC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 10.96 0.56 2.75e-23 Platelet count; CESC cis rs7818688 0.591 rs10098025 chr8:95989583 T/A cg16049864 chr8:95962084 TP53INP1 0.52 5.29 0.31 2.54e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg08822215 chr16:89438651 ANKRD11 0.39 6.01 0.35 6.1e-9 Multiple myeloma (IgH translocation); CESC cis rs2456568 0.548 rs10765647 chr11:93662459 T/C cg26875233 chr11:93583750 C11orf90 -0.33 -5.86 -0.34 1.37e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs3806843 0.933 rs2879087 chr5:140188575 G/C cg26395211 chr5:140044315 WDR55 -0.41 -5.19 -0.3 4.17e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg20307385 chr11:47447363 PSMC3 0.69 8.91 0.48 8.43e-17 Subjective well-being; CESC cis rs7582720 1.000 rs76461893 chr2:203865515 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg13770153 chr20:60521292 NA -0.43 -5.57 -0.32 6.26e-8 Body mass index; CESC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg11366901 chr6:160182831 ACAT2 0.65 8.23 0.45 8.74e-15 Age-related macular degeneration (geographic atrophy); CESC cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.51 0.46 1.33e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9894429 0.690 rs11869779 chr17:79570067 C/T cg18240062 chr17:79603768 NPLOC4 -0.87 -13.0 -0.62 3.32e-30 Eye color traits; CESC cis rs6460942 1.000 rs7796485 chr7:12405676 G/A cg02935154 chr7:12443704 VWDE -0.57 -5.8 -0.34 1.89e-8 Coronary artery disease; CESC cis rs11122272 0.735 rs2739516 chr1:231505527 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg10691866 chr7:65817282 TPST1 0.33 5.31 0.31 2.35e-7 Aortic root size; CESC cis rs763121 0.853 rs1065201 chr22:39069510 T/C cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg05863683 chr7:1912471 MAD1L1 0.44 6.65 0.38 1.65e-10 Bipolar disorder and schizophrenia; CESC cis rs10876993 0.890 rs1585781 chr12:58056701 T/G cg18357645 chr12:58087776 OS9 0.63 10.22 0.53 7.1e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs344364 0.511 rs911391 chr16:1947016 C/A cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC cis rs6964587 0.692 rs4729021 chr7:91758422 C/A cg17063962 chr7:91808500 NA 0.42 5.9 0.34 1.13e-8 Breast cancer; CESC cis rs11098499 0.863 rs12502389 chr4:120454191 A/G cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.24e-28 Corneal astigmatism; CESC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.25e-30 Prudent dietary pattern; CESC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg23281280 chr6:28129359 ZNF389 0.48 6.33 0.36 1.07e-9 Parkinson's disease; CESC cis rs3741798 1.000 rs78028836 chr12:12485448 G/A cg08615371 chr12:12503544 MANSC1 0.87 6.35 0.36 9.19e-10 Cerebrospinal fluid biomarker levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18550509 chr15:100273145 LYSMD4 0.62 7.38 0.41 2.09e-12 Gut microbiome composition (summer); CESC cis rs1538970 0.781 rs10890330 chr1:45920406 G/A cg24296786 chr1:45957014 TESK2 -0.46 -5.15 -0.3 5.16e-7 Platelet count; CESC cis rs7918232 0.882 rs6415983 chr10:27357211 A/G cg14442939 chr10:27389572 ANKRD26 0.59 5.47 0.32 1.03e-7 Breast cancer; CESC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg26314531 chr2:26401878 FAM59B -0.82 -9.0 -0.48 4.62e-17 Gut microbiome composition (summer); CESC cis rs1801251 0.963 rs35362030 chr2:233612845 A/G cg08000102 chr2:233561755 GIGYF2 0.65 9.33 0.5 4.51e-18 Coronary artery disease; CESC cis rs8067354 0.507 rs72840511 chr17:57806011 G/T cg13753209 chr17:57696993 CLTC 0.58 6.29 0.36 1.28e-9 Hemoglobin concentration; CESC cis rs847851 0.617 rs73403805 chr6:34964724 C/T cg13137465 chr6:34857473 ANKS1A 0.7 7.19 0.4 6.42e-12 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.850 rs11641147 chr16:89813589 C/T cg06558623 chr16:89946397 TCF25 1.19 9.55 0.51 8.99e-19 Skin colour saturation; CESC cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg04166393 chr7:2884313 GNA12 0.39 5.1 0.3 6.42e-7 Height; CESC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 7.09 0.4 1.2e-11 Lymphocyte counts; CESC cis rs3096299 0.967 rs28689480 chr16:89460093 T/C cg08392591 chr16:89556376 ANKRD11 0.42 5.29 0.31 2.53e-7 Multiple myeloma (IgH translocation); CESC cis rs6690583 0.623 rs893620 chr1:85425821 T/C cg22153463 chr1:85462885 MCOLN2 0.79 7.7 0.43 2.71e-13 Serum sulfate level; CESC trans rs2727020 0.615 rs35423199 chr11:49514914 T/C cg03929089 chr4:120376271 NA -0.85 -13.58 -0.64 2.94e-32 Coronary artery disease; CESC cis rs77216612 0.835 rs56692845 chr12:12887811 C/T cg04607235 chr12:12878440 APOLD1 -0.99 -14.75 -0.67 2.4e-36 Lymphocyte counts; CESC cis rs9899728 0.539 rs12940199 chr17:73054759 C/T cg27626185 chr17:73056755 KCTD2 -0.95 -8.43 -0.46 2.23e-15 Alzheimer's disease or small vessel stroke; CESC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg13628971 chr7:2884303 GNA12 0.64 8.84 0.48 1.33e-16 Height; CESC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg25754956 chr12:51612065 POU6F1 0.75 8.32 0.46 4.65e-15 Cisplatin-induced ototoxicity; CESC cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg20891558 chr2:74357851 NA 0.8 11.63 0.58 1.59e-25 Gestational age at birth (maternal effect); CESC trans rs61931739 0.534 rs7965503 chr12:34199349 A/G cg26384229 chr12:38710491 ALG10B 0.65 9.14 0.49 1.71e-17 Morning vs. evening chronotype; CESC cis rs11645898 0.748 rs72787056 chr16:72099694 C/T cg14768367 chr16:72042858 DHODH -0.8 -6.39 -0.37 7.41e-10 Blood protein levels; CESC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs4253772 0.938 rs11704979 chr22:46632994 G/A cg00784671 chr22:46762841 CELSR1 -0.57 -5.63 -0.33 4.54e-8 LDL cholesterol;Cholesterol, total; CESC cis rs2249625 0.844 rs2496497 chr6:72884121 T/C cg18830697 chr6:72922368 RIMS1 -0.39 -5.5 -0.32 8.88e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs9325144 0.560 rs2387923 chr12:38662677 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.6 -0.51 6.43e-19 Morning vs. evening chronotype; CESC trans rs2764766 0.721 rs151882 chr5:127188318 G/C cg15764593 chr10:829463 NA -0.4 -6.19 -0.36 2.33e-9 Schizophrenia; CESC cis rs698813 0.763 rs786614 chr2:44590567 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.83 0.34 1.58e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2625529 0.652 rs2957361 chr15:72345218 G/A cg16672083 chr15:72433130 SENP8 0.42 6.57 0.37 2.59e-10 Red blood cell count; CESC cis rs7927771 1.000 rs7947730 chr11:47786184 C/T cg20307385 chr11:47447363 PSMC3 -0.51 -6.23 -0.36 1.79e-9 Subjective well-being; CESC cis rs13064411 0.696 rs6438159 chr3:113217341 T/C cg18753928 chr3:113234510 CCDC52 -0.51 -6.22 -0.36 1.9e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs2274273 0.840 rs10467798 chr14:55724927 C/T cg04306507 chr14:55594613 LGALS3 0.3 5.86 0.34 1.37e-8 Protein biomarker; CESC cis rs9611565 0.545 rs5758432 chr22:42111693 T/C cg03806693 chr22:41940476 POLR3H 1.16 13.32 0.63 2.5e-31 Vitiligo; CESC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg03188948 chr7:1209495 NA 0.72 6.94 0.39 2.94e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7845219 0.506 rs12548999 chr8:95929843 C/T cg09323728 chr8:95962352 TP53INP1 -0.31 -5.91 -0.34 1.05e-8 Type 2 diabetes; CESC cis rs7089973 0.604 rs2420067 chr10:116590348 A/G cg03647239 chr10:116582469 FAM160B1 0.43 5.29 0.31 2.6e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.98 9.31 0.5 5.22e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8141529 0.778 rs9625566 chr22:29162506 G/A cg15103426 chr22:29168792 CCDC117 0.7 9.96 0.52 4.8e-20 Lymphocyte counts; CESC cis rs11030122 0.604 rs10835557 chr11:4083121 A/G cg18678763 chr11:4115507 RRM1 -0.49 -6.5 -0.37 4.05e-10 Mean platelet volume;Platelet distribution width; CESC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg24250549 chr1:154909240 PMVK 0.49 6.26 0.36 1.55e-9 Prostate cancer; CESC cis rs1018836 0.923 rs62526886 chr8:91627676 G/A cg16814680 chr8:91681699 NA -0.72 -10.07 -0.53 2.16e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg22823121 chr1:150693482 HORMAD1 -0.49 -7.25 -0.41 4.56e-12 Tonsillectomy; CESC cis rs7264396 0.563 rs73902913 chr20:34432784 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.61 6.21 0.36 2.05e-9 Total cholesterol levels; CESC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC cis rs7523050 0.643 rs35907086 chr1:109406625 A/G cg08274380 chr1:109419600 GPSM2 0.91 5.92 0.34 9.78e-9 Fat distribution (HIV); CESC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg08888203 chr3:10149979 C3orf24 0.48 6.09 0.35 4.02e-9 Alzheimer's disease; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg02739853 chr6:159398502 RSPH3 0.43 6.35 0.36 9.44e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7944584 0.502 rs10769256 chr11:47378396 C/T cg20307385 chr11:47447363 PSMC3 0.84 11.68 0.58 1.04e-25 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs887829 0.569 rs3755319 chr2:234667582 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -5.98 -0.34 7.1e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs9303401 1.000 rs6503877 chr17:56841948 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.73 9.6 0.51 6.34e-19 Cognitive test performance; CESC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg26338869 chr17:61819248 STRADA 0.67 8.75 0.47 2.6e-16 Prudent dietary pattern; CESC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs11676348 0.755 rs13410318 chr2:219022910 T/G cg20019365 chr2:219134978 PNKD;AAMP 0.45 5.83 0.34 1.6e-8 Ulcerative colitis; CESC cis rs727505 0.789 rs4731233 chr7:124736291 C/T cg23710748 chr7:124431027 NA -0.4 -6.53 -0.37 3.37e-10 Lewy body disease; CESC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg03709012 chr19:19516395 GATAD2A 1.0 15.33 0.69 1.99e-38 Tonsillectomy; CESC cis rs6429082 0.818 rs291344 chr1:235663860 C/G cg26050004 chr1:235667680 B3GALNT2 -0.64 -7.89 -0.44 7.97e-14 Adiposity; CESC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.08 10.6 0.55 3.94e-22 Platelet count; CESC cis rs9914988 0.887 rs4795463 chr17:27146389 G/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs9487051 1.000 rs1546723 chr6:109625879 G/A cg01475377 chr6:109611718 NA -0.4 -6.04 -0.35 5.31e-9 Reticulocyte fraction of red cells; CESC cis rs2625529 0.824 rs2415121 chr15:72134018 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.37 -0.41 2.15e-12 Red blood cell count; CESC cis rs72945132 0.882 rs6592522 chr11:70128271 G/A cg14191688 chr11:70257035 CTTN 0.42 5.15 0.3 5.16e-7 Coronary artery disease; CESC cis rs826838 0.967 rs826858 chr12:39116731 A/G cg13010199 chr12:38710504 ALG10B -0.46 -6.44 -0.37 5.5e-10 Heart rate; CESC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.24 -0.36 1.77e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3105593 1.000 rs11636964 chr15:50899616 A/G cg08437265 chr15:50716283 USP8 0.41 5.37 0.31 1.76e-7 QT interval; CESC cis rs9911578 0.933 rs2531725 chr17:56517962 G/A cg12560992 chr17:57184187 TRIM37 0.91 15.37 0.69 1.45e-38 Intelligence (multi-trait analysis); CESC cis rs870825 0.655 rs7683556 chr4:185632019 T/A cg04058563 chr4:185651563 MLF1IP 0.63 6.91 0.39 3.7e-11 Blood protein levels; CESC cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg25427524 chr10:38739819 LOC399744 -0.71 -10.4 -0.54 1.84e-21 Extrinsic epigenetic age acceleration; CESC cis rs9926296 0.585 rs8058009 chr16:89856439 G/C cg27130406 chr16:89901659 SPIRE2 -0.55 -6.52 -0.37 3.49e-10 Vitiligo; CESC cis rs950169 0.840 rs12905223 chr15:85114268 T/C cg17507749 chr15:85114479 UBE2QP1 0.54 6.15 0.35 2.86e-9 Schizophrenia; CESC cis rs4481887 0.927 rs10788765 chr1:248445642 A/G cg00666640 chr1:248458726 OR2T12 -0.4 -6.81 -0.39 6.58e-11 Common traits (Other); CESC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg07677032 chr17:61819896 STRADA 0.44 5.84 0.34 1.5e-8 Prudent dietary pattern; CESC cis rs2243480 1.000 rs316315 chr7:65591205 C/T cg18252515 chr7:66147081 NA 1.18 13.81 0.65 4.73e-33 Diabetic kidney disease; CESC cis rs3733585 0.673 rs4627861 chr4:9954238 T/G cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.85 0.34 1.46e-8 Bipolar disorder; CESC cis rs55823223 0.680 rs57287238 chr17:73850940 T/C cg23806715 chr17:73775811 H3F3B 0.61 6.69 0.38 1.34e-10 Psoriasis; CESC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg06873352 chr17:61820015 STRADA 0.48 6.94 0.39 3.07e-11 Height; CESC cis rs7208859 0.623 rs8082537 chr17:29015932 T/C cg19761014 chr17:28927070 LRRC37B2 0.65 5.77 0.33 2.21e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10791323 0.569 rs546381 chr11:133760651 T/G cg15485101 chr11:133734466 NA 0.3 5.06 0.3 7.85e-7 Childhood ear infection; CESC cis rs2075671 0.903 rs11520986 chr7:100276994 A/G cg16850897 chr7:100343110 ZAN -0.7 -9.06 -0.49 2.89e-17 Other erythrocyte phenotypes; CESC cis rs11677416 1.000 rs3783514 chr2:113547425 A/G cg27083787 chr2:113543245 IL1A 0.61 7.53 0.42 7.75e-13 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg27286337 chr10:134555280 INPP5A 0.63 7.32 0.41 3.04e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4523957 0.855 rs1231206 chr17:2125605 G/A cg16513277 chr17:2031491 SMG6 -0.62 -8.67 -0.47 4.51e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2228479 0.850 rs17233497 chr16:89815152 G/A cg06558623 chr16:89946397 TCF25 1.04 6.59 0.37 2.43e-10 Skin colour saturation; CESC cis rs9911578 0.967 rs302843 chr17:56727986 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC cis rs3126085 0.935 rs11204941 chr1:152203343 A/G cg03465714 chr1:152285911 FLG -0.44 -5.37 -0.31 1.73e-7 Atopic dermatitis; CESC cis rs7216064 0.954 rs8079291 chr17:65887622 A/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.82 -0.48 1.55e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03576123 chr11:487126 PTDSS2 -1.07 -11.04 -0.56 1.45e-23 Body mass index; CESC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg19717773 chr7:2847554 GNA12 -0.57 -7.79 -0.43 1.55e-13 Height; CESC cis rs9929218 0.861 rs3114409 chr16:68732049 A/C cg02972257 chr16:68554789 NA 0.58 6.96 0.39 2.72e-11 Colorectal cancer; CESC trans rs11088226 0.846 rs2154501 chr21:33926451 G/A cg09050820 chr6:167586206 TCP10L2 0.63 6.88 0.39 4.22e-11 Gastritis; CESC cis rs453301 0.571 rs330057 chr8:9089793 C/T cg17143192 chr8:8559678 CLDN23 -0.44 -5.3 -0.31 2.38e-7 Joint mobility (Beighton score); CESC cis rs3806843 0.771 rs2563336 chr5:140107199 A/G cg26395211 chr5:140044315 WDR55 0.47 6.05 0.35 4.82e-9 Depressive symptoms (multi-trait analysis); CESC cis rs7264396 0.563 rs6058296 chr20:34269225 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.9 -9.78 -0.51 1.8e-19 Total cholesterol levels; CESC cis rs9359856 0.623 rs1179907 chr6:90324849 A/G cg13799429 chr6:90582589 CASP8AP2 -0.55 -6.32 -0.36 1.1e-9 Bipolar disorder; CESC trans rs10832139 0.553 rs7929534 chr11:13945218 G/T cg11511669 chr12:131556214 GPR133 0.5 6.06 0.35 4.74e-9 P wave terminal force; CESC cis rs6598955 0.543 rs3795687 chr1:26560745 G/A cg04990556 chr1:26633338 UBXN11 0.83 9.48 0.5 1.56e-18 Obesity-related traits; CESC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg09699651 chr6:150184138 LRP11 0.5 6.09 0.35 4.03e-9 Lung cancer; CESC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.9 0.59 1.94e-26 Alzheimer's disease; CESC cis rs826838 1.000 rs12366971 chr12:38737687 T/G cg26384229 chr12:38710491 ALG10B 0.82 14.66 0.67 4.97e-36 Heart rate; CESC cis rs8040855 0.756 rs2342118 chr15:85693016 C/T cg08123816 chr15:85640762 PDE8A 0.34 5.31 0.31 2.27e-7 Bulimia nervosa; CESC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg13607699 chr17:42295918 UBTF 0.59 7.54 0.42 7.35e-13 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10491242 chr19:50366052 PNKP -0.56 -6.49 -0.37 4.23e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21893394 chr19:10342123 S1PR2 0.62 7.14 0.4 9.02e-12 Gut microbiome composition (summer); CESC cis rs9322193 0.884 rs7744105 chr6:150170444 A/G cg07701084 chr6:150067640 NUP43 0.38 5.09 0.3 6.88e-7 Lung cancer; CESC cis rs6752107 0.967 rs3792111 chr2:234179690 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.47 6.37 0.36 8.49e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs3741151 1.000 rs76887714 chr11:73045500 C/T cg17517138 chr11:73019481 ARHGEF17 0.62 5.15 0.3 5.08e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs2286503 0.752 rs59538378 chr7:22877097 G/A cg11367502 chr7:22862612 TOMM7 0.43 5.62 0.33 4.76e-8 Fibrinogen; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27164762 chr5:175815688 HIGD2A;NOP16 0.48 6.3 0.36 1.21e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7208859 0.623 rs12103440 chr17:29086657 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg25072359 chr17:41440525 NA 0.47 6.4 0.37 6.83e-10 Menopause (age at onset); CESC trans rs2391518 0.553 rs2969006 chr4:130781463 G/T cg04981619 chr2:43328122 NA 0.38 6.0 0.35 6.59e-9 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05903298 chr11:107992155 ACAT1 0.55 6.76 0.38 8.95e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14692768 chr2:219925688 IHH -0.58 -6.95 -0.39 2.79e-11 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg08470875 chr2:26401718 FAM59B 0.75 7.79 0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg06453172 chr10:134556979 INPP5A -0.42 -5.32 -0.31 2.19e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1153858 1.000 rs16952714 chr15:45650358 G/A cg21132104 chr15:45694354 SPATA5L1 0.84 11.41 0.57 8.8e-25 Homoarginine levels; CESC cis rs9303280 0.806 rs12709365 chr17:38027400 A/G cg20243544 chr17:37824526 PNMT 0.5 6.43 0.37 5.86e-10 Self-reported allergy; CESC cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg19077165 chr18:44547161 KATNAL2 0.53 7.59 0.42 5.33e-13 Personality dimensions; CESC cis rs9309473 0.948 rs2421577 chr2:73840998 G/T cg20560298 chr2:73613845 ALMS1 -0.43 -5.78 -0.33 2.12e-8 Metabolite levels; CESC cis rs1577917 0.771 rs2842602 chr6:86331887 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.54 -7.42 -0.41 1.63e-12 Response to antipsychotic treatment; CESC cis rs7267979 0.816 rs443009 chr20:25499817 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.77 -14.59 -0.67 8.94e-36 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10975873 chr1:149783778 HIST2H2BF -0.6 -6.65 -0.38 1.64e-10 Gut microbiome composition (summer); CESC cis rs116095464 0.510 rs10057501 chr5:239545 T/C cg20965017 chr5:231967 SDHA -0.47 -5.29 -0.31 2.6e-7 Breast cancer; CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06343987 chr4:99849709 EIF4E -0.59 -6.94 -0.39 2.92e-11 Gut microbiome composition (summer); CESC trans rs7772486 0.686 rs9376961 chr6:146048737 C/T cg09789590 chr19:46800479 HIF3A -0.44 -6.26 -0.36 1.59e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs428668 0.523 rs3926389 chr5:150677806 C/T cg14086364 chr5:150678334 SLC36A3 0.49 7.09 0.4 1.2e-11 Skin aging (microtopography measurement); CESC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg18402987 chr7:1209562 NA 0.71 7.26 0.41 4.25e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg21770322 chr7:97807741 LMTK2 0.57 8.61 0.47 6.62e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg08470875 chr2:26401718 FAM59B -0.62 -6.71 -0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs4268898 0.636 rs72787371 chr2:24570073 T/A cg06627628 chr2:24431161 ITSN2 -1.0 -11.45 -0.58 6.19e-25 Asthma; CESC cis rs7223966 1.000 rs6504171 chr17:61710010 G/A cg11494091 chr17:61959527 GH2 0.38 5.44 0.32 1.24e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs4604732 0.536 rs12049066 chr1:247642655 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.59 7.97 0.44 4.65e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg15112475 chr7:1198522 ZFAND2A -0.42 -6.66 -0.38 1.61e-10 Longevity;Endometriosis; CESC cis rs6541297 0.653 rs4846841 chr1:230302661 A/G cg20703242 chr1:230279135 GALNT2 0.38 5.84 0.34 1.54e-8 Coronary artery disease; CESC cis rs757110 0.705 rs10832778 chr11:17394073 C/G cg15432903 chr11:17409602 KCNJ11 0.6 8.47 0.46 1.74e-15 Type 2 diabetes; CESC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg24531977 chr5:56204891 C5orf35 -0.88 -11.15 -0.57 6.07e-24 Initial pursuit acceleration; CESC cis rs11098499 0.722 rs7673476 chr4:120248683 C/T cg09307838 chr4:120376055 NA 0.76 10.25 0.53 5.52e-21 Corneal astigmatism; CESC cis rs28830936 0.967 rs9672671 chr15:41917075 C/T cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.36 -5.16 -0.3 4.94e-7 Diastolic blood pressure; CESC cis rs10911232 0.507 rs10911198 chr1:182997318 G/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 9.26 0.49 7.13e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg23758822 chr17:41437982 NA 1.05 16.2 0.71 1.69e-41 Menopause (age at onset); CESC cis rs7107174 1.000 rs10899486 chr11:78072398 A/G cg02023728 chr11:77925099 USP35 0.47 6.23 0.36 1.82e-9 Testicular germ cell tumor; CESC cis rs7107174 0.901 rs2450136 chr11:77925273 T/G cg02023728 chr11:77925099 USP35 0.49 6.89 0.39 4.06e-11 Testicular germ cell tumor; CESC cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg21951975 chr1:209979733 IRF6 0.59 7.16 0.4 8.01e-12 Cleft lip with or without cleft palate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10224311 chr22:35817371 MCM5 0.4 6.0 0.35 6.36e-9 Fibrinogen levels; CESC cis rs7580658 0.680 rs12468304 chr2:128193812 A/G cg10021288 chr2:128175891 PROC 0.41 6.02 0.35 5.72e-9 Protein C levels; CESC cis rs2404602 0.536 rs7165025 chr15:76766434 G/A cg22467129 chr15:76604101 ETFA -0.38 -5.84 -0.34 1.53e-8 Blood metabolite levels; CESC cis rs2115536 0.692 rs8036559 chr15:80170563 C/T cg11839771 chr15:80205821 ST20 -0.39 -5.7 -0.33 3.16e-8 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs11264213 0.551 rs172081 chr1:36497498 T/G cg27506609 chr1:36549197 TEKT2 0.76 6.98 0.39 2.31e-11 Schizophrenia; CESC cis rs4919694 1.000 rs11191445 chr10:104651055 C/T cg04362960 chr10:104952993 NT5C2 0.78 6.53 0.37 3.35e-10 Arsenic metabolism; CESC cis rs3916 0.794 rs10431384 chr12:121127347 C/T cg26008908 chr12:120799332 MSI1 -0.32 -5.13 -0.3 5.61e-7 Urinary metabolites (H-NMR features); CESC cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg23583168 chr7:148888333 NA -0.75 -9.95 -0.52 4.91e-20 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19138250 chr10:69524126 NA -0.57 -6.47 -0.37 4.6e-10 Gut microbiome composition (summer); CESC cis rs6815814 0.731 rs11096956 chr4:38776180 G/T cg02016764 chr4:38805732 TLR1 -0.45 -6.16 -0.35 2.65e-9 Breast cancer; CESC cis rs2072732 0.861 rs12040299 chr1:2951041 C/T cg15211996 chr1:2936768 ACTRT2 0.33 5.88 0.34 1.22e-8 Plateletcrit; CESC cis rs6088590 1.000 rs6087623 chr20:33317662 C/G cg24642439 chr20:33292090 TP53INP2 0.84 11.76 0.59 5.72e-26 Coronary artery disease; CESC cis rs2243480 1.000 rs1167613 chr7:65487439 C/T cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg12373951 chr3:133503437 NA 0.44 6.46 0.37 5.01e-10 Iron status biomarkers; CESC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg22433210 chr17:43662623 NA 0.96 10.69 0.55 2.12e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26667821 chr1:155099774 EFNA1 -0.58 -6.36 -0.36 8.77e-10 Gut microbiome composition (summer); CESC cis rs2742417 0.603 rs2673032 chr3:45756927 C/T cg04837898 chr3:45731254 SACM1L -0.48 -6.55 -0.37 2.96e-10 Response to anti-depressant treatment in major depressive disorder; CESC cis rs2108622 0.958 rs79400241 chr19:15984402 C/G cg13772218 chr19:15982569 NA 0.38 7.05 0.4 1.52e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.68 0.38 1.41e-10 Intelligence (multi-trait analysis); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg21584983 chr19:11640070 ECSIT -0.46 -6.43 -0.37 5.77e-10 Height; CESC cis rs2235642 0.533 rs2667679 chr16:1654946 G/A cg09080909 chr16:1797204 MAPK8IP3 -0.45 -6.22 -0.36 1.96e-9 Coronary artery disease; CESC cis rs5769707 0.616 rs6009786 chr22:50015145 A/G cg20744362 chr22:50050164 C22orf34 0.36 5.14 0.3 5.33e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs9346455 1.000 rs9342829 chr6:72020763 G/C cg27238071 chr6:71998145 OGFRL1 0.62 5.55 0.32 6.98e-8 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs57506017 0.585 rs12668625 chr7:12269817 G/A cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.58e-7 Neuroticism; CESC cis rs6582630 0.519 rs11514078 chr12:38408817 G/C cg26384229 chr12:38710491 ALG10B 0.68 9.85 0.52 1.03e-19 Drug-induced liver injury (flucloxacillin); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11081703 chr12:108909056 FICD -0.41 -6.1 -0.35 3.68e-9 Gambling; CESC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg24562669 chr7:97807699 LMTK2 0.52 7.74 0.43 2.16e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs11098499 0.913 rs10010696 chr4:120164303 T/C cg09307838 chr4:120376055 NA 0.87 11.44 0.57 6.97e-25 Corneal astigmatism; CESC cis rs1878931 0.555 rs27228 chr16:3431933 C/T cg22508957 chr16:3507546 NAT15 0.45 5.88 0.34 1.24e-8 Body mass index (adult); CESC cis rs1570884 0.516 rs7330830 chr13:50167929 T/A cg08779649 chr13:50194554 NA 0.4 6.93 0.39 3.17e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs921968 0.565 rs1078803 chr2:219606538 A/C cg02176678 chr2:219576539 TTLL4 0.45 7.93 0.44 6.07e-14 Mean corpuscular hemoglobin concentration; CESC cis rs262150 0.579 rs4481540 chr7:158785846 A/G cg23096020 chr7:158799433 NA 0.45 5.15 0.3 5.21e-7 Facial morphology (factor 20); CESC cis rs7523050 0.643 rs17563938 chr1:109401654 C/T cg08274380 chr1:109419600 GPSM2 0.86 5.69 0.33 3.36e-8 Fat distribution (HIV); CESC cis rs727505 0.954 rs66691367 chr7:124654217 G/T cg23710748 chr7:124431027 NA -0.45 -6.98 -0.39 2.31e-11 Lewy body disease; CESC cis rs9486719 1.000 rs1303852 chr6:96864523 C/T cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs4727027 0.704 rs1123992 chr7:148907201 C/G cg23583168 chr7:148888333 NA -0.84 -11.97 -0.59 1.13e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7116495 1.000 rs4338555 chr11:71755696 T/C cg26138937 chr11:71823887 C11orf51 -0.85 -7.16 -0.4 8.12e-12 Severe influenza A (H1N1) infection; CESC trans rs9929218 0.954 rs34530130 chr16:68827620 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.06 -0.44 2.65e-14 Colorectal cancer; CESC cis rs9858542 0.903 rs35999162 chr3:49597230 C/G cg07274523 chr3:49395745 GPX1 0.65 8.34 0.46 4.1e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9815354 0.516 rs75047809 chr3:42033437 T/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.46 6.16 0.35 2.63e-9 Personality dimensions; CESC cis rs660498 0.516 rs638324 chr10:27730261 A/C cg25705717 chr10:27608719 NA 0.43 5.41 0.32 1.43e-7 Asthma (childhood onset); CESC cis rs12900413 0.687 rs28465116 chr15:90310152 T/C cg24249390 chr15:90295951 MESP1 -0.4 -5.5 -0.32 9.05e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs61935443 0.832 rs11107773 chr12:95282000 C/T cg21533806 chr12:95267307 NA 0.58 7.11 0.4 1.07e-11 Schizophrenia; CESC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg13393036 chr8:95962371 TP53INP1 -0.55 -12.25 -0.6 1.25e-27 Type 2 diabetes; CESC cis rs10751667 1.000 rs10794349 chr11:945678 T/C cg20946044 chr11:1010712 AP2A2 -0.44 -5.86 -0.34 1.4e-8 Alzheimer's disease (late onset); CESC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg27535305 chr1:53392650 SCP2 0.32 5.68 0.33 3.6e-8 Monocyte count; CESC cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg11764359 chr7:65958608 NA 0.66 8.46 0.46 1.82e-15 Aortic root size; CESC cis rs7216064 0.906 rs1976052 chr17:65830578 C/T cg12091567 chr17:66097778 LOC651250 -0.86 -8.58 -0.47 8.22e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11718455 0.960 rs11921942 chr3:44007957 T/C cg08738300 chr3:44038990 NA 0.46 6.15 0.35 2.87e-9 Coronary artery disease; CESC cis rs1568889 1.000 rs66857704 chr11:28212346 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.74 9.23 0.49 8.63e-18 Bipolar disorder; CESC cis rs1348850 0.668 rs6734683 chr2:178494012 C/G cg22681709 chr2:178499509 PDE11A -0.41 -5.9 -0.34 1.09e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2455799 0.634 rs6771390 chr3:15906637 C/G cg16303742 chr3:15540471 COLQ -0.39 -5.91 -0.34 1.06e-8 Mean platelet volume; CESC cis rs9790314 1.000 rs7653361 chr3:160992291 C/T cg04691961 chr3:161091175 C3orf57 -0.41 -5.27 -0.31 2.87e-7 Morning vs. evening chronotype; CESC cis rs10779751 0.762 rs6540965 chr1:11325521 C/G cg08854313 chr1:11322531 MTOR -0.67 -9.07 -0.49 2.74e-17 Body mass index; CESC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg11814155 chr7:99998594 ZCWPW1 0.5 5.11 0.3 6.07e-7 Platelet count; CESC cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg20307385 chr11:47447363 PSMC3 0.57 6.87 0.39 4.69e-11 Subjective well-being; CESC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.98 10.48 0.54 9.63e-22 Platelet count; CESC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg11764359 chr7:65958608 NA -0.67 -8.78 -0.47 2.12e-16 Aortic root size; CESC trans rs61931739 0.517 rs7975714 chr12:34055611 T/C cg26384229 chr12:38710491 ALG10B 0.6 8.36 0.46 3.68e-15 Morning vs. evening chronotype; CESC cis rs2108622 0.727 rs62106155 chr19:15980360 G/C cg13772218 chr19:15982569 NA 0.3 5.89 0.34 1.18e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC trans rs1116547 0.571 rs12519323 chr5:112894805 A/G cg10115368 chr14:100435663 NA 0.51 6.02 0.35 5.91e-9 Cerebral amyloid angiopathy; CESC cis rs2573652 1.000 rs12440866 chr15:100517010 G/A cg00587665 chr15:100533223 ADAMTS17 -0.41 -6.53 -0.37 3.34e-10 Height; CESC cis rs11122272 0.705 rs2486731 chr1:231532511 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.48 6.54 0.37 3.2e-10 Hemoglobin concentration; CESC cis rs12042052 0.793 rs7534632 chr1:232910796 G/A cg00951395 chr1:232941775 KIAA1383 0.69 6.24 0.36 1.76e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs1030877 0.515 rs2576741 chr2:105897964 T/C cg02079111 chr2:105885981 TGFBRAP1 0.49 6.51 0.37 3.66e-10 Obesity-related traits; CESC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg08736216 chr1:53307985 ZYG11A -0.36 -6.21 -0.36 2.06e-9 Monocyte count; CESC trans rs89107 0.575 rs72958930 chr6:118983681 G/C cg15017278 chr16:127449 MPG -0.32 -6.0 -0.35 6.53e-9 Cardiac structure and function; CESC cis rs12422267 0.536 rs12303540 chr12:132609679 A/G cg09764611 chr12:132620959 NA 0.51 6.55 0.37 3.02e-10 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs6545883 0.894 rs2694639 chr2:61595291 G/A cg15711740 chr2:61764176 XPO1 0.4 5.07 0.3 7.63e-7 Tuberculosis; CESC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.26 0.36 1.51e-9 Cystic fibrosis severity; CESC cis rs11214589 0.774 rs877137 chr11:113256330 C/T cg14159747 chr11:113255604 NA 0.36 6.73 0.38 1.03e-10 Neuroticism; CESC cis rs9467773 0.595 rs7767847 chr6:26597893 A/T cg11502198 chr6:26597334 ABT1 0.49 7.03 0.4 1.79e-11 Intelligence (multi-trait analysis); CESC cis rs7589342 0.628 rs35482041 chr2:106409436 A/G cg16077055 chr2:106428750 NCK2 0.55 6.85 0.39 5.18e-11 Addiction; CESC cis rs1451375 0.652 rs10265930 chr7:50627449 C/T cg14593290 chr7:50529359 DDC 0.49 5.88 0.34 1.24e-8 Malaria; CESC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg15112475 chr7:1198522 ZFAND2A -0.33 -5.12 -0.3 5.75e-7 Longevity;Endometriosis; CESC trans rs7849270 1.000 rs713219 chr9:131900920 T/C cg05583848 chr6:35265411 DEF6 -0.46 -6.36 -0.36 8.9e-10 Blood metabolite ratios; CESC cis rs2594989 1.000 rs346081 chr3:11329085 A/G cg01796438 chr3:11312864 ATG7 -0.46 -5.19 -0.3 4.09e-7 Circulating chemerin levels; CESC cis rs1799949 0.930 rs34210004 chr17:41370337 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.47 6.48 0.37 4.38e-10 Menopause (age at onset); CESC cis rs17023223 0.537 rs10923766 chr1:119726932 G/A cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg16240275 chr20:61666158 NCRNA00029 0.5 8.91 0.48 8.46e-17 Prostate cancer (SNP x SNP interaction); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg23290719 chr2:241511151 RNPEPL1 -0.47 -6.25 -0.36 1.65e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg00769240 chr8:12517080 NA -0.44 -6.05 -0.35 4.91e-9 Blood pressure (smoking interaction); CESC cis rs12477438 0.520 rs6741773 chr2:99738962 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.4 0.69 1.17e-38 Chronic sinus infection; CESC cis rs7772486 0.875 rs6934467 chr6:146410529 G/T cg05347473 chr6:146136440 FBXO30 0.5 6.57 0.37 2.61e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg11764359 chr7:65958608 NA 0.73 8.93 0.48 7.48e-17 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27272293 chr12:76531007 NA 0.51 6.65 0.38 1.7e-10 Fibrinogen levels; CESC cis rs9911578 0.967 rs302843 chr17:56727986 C/T cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC cis rs4975616 0.804 rs31489 chr5:1342714 C/A cg06550200 chr5:1325588 CLPTM1L -0.66 -9.83 -0.52 1.24e-19 Lung cancer; CESC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.74 9.98 0.52 3.9e-20 Total body bone mineral density; CESC cis rs757110 0.933 rs4148646 chr11:17415190 C/G cg15432903 chr11:17409602 KCNJ11 0.65 9.19 0.49 1.17e-17 Type 2 diabetes; CESC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg00784671 chr22:46762841 CELSR1 -0.48 -5.59 -0.32 5.77e-8 LDL cholesterol;Cholesterol, total; CESC trans rs4140564 0.557 rs12145449 chr1:186665945 A/C cg22110973 chr15:91499626 RCCD1 0.77 6.23 0.36 1.8e-9 Knee osteoarthritis; CESC cis rs9399135 0.967 rs2183709 chr6:135377091 C/T cg24558204 chr6:135376177 HBS1L 0.52 7.19 0.4 6.52e-12 Red blood cell count; CESC cis rs7178572 0.568 rs11858641 chr15:77585820 C/T cg22256960 chr15:77711686 NA -0.53 -6.6 -0.38 2.26e-10 Type 2 diabetes; CESC cis rs1559088 1.000 rs12985438 chr19:33559368 G/A cg27124370 chr19:33622961 WDR88 0.43 5.42 0.32 1.37e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2836950 0.772 rs62222988 chr21:40569508 T/C cg17971929 chr21:40555470 PSMG1 -0.61 -7.31 -0.41 3.09e-12 Menarche (age at onset); CESC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg18876405 chr7:65276391 NA -0.54 -7.7 -0.43 2.74e-13 Aortic root size; CESC cis rs9549367 0.724 rs7985335 chr13:113869244 G/T cg18105134 chr13:113819100 PROZ 0.62 8.22 0.45 9.21e-15 Platelet distribution width; CESC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.51e-11 Developmental language disorder (linguistic errors); CESC cis rs27434 0.583 rs151911 chr5:96157084 A/G cg16492584 chr5:96139282 ERAP1 -0.36 -5.09 -0.3 6.81e-7 Ankylosing spondylitis; CESC cis rs12464559 0.649 rs3922997 chr2:152609704 C/T cg01189475 chr2:152685088 ARL5A 0.65 5.56 0.32 6.46e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs4073221 0.520 rs66569729 chr3:18189623 A/C cg07694806 chr3:18168406 NA -0.71 -5.59 -0.32 5.74e-8 Parkinson's disease; CESC cis rs1707322 1.000 rs10890376 chr1:46406582 C/T cg03146154 chr1:46216737 IPP 0.78 10.77 0.55 1.17e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35110281 0.687 rs4819284 chr21:45084548 C/T cg04455712 chr21:45112962 RRP1B 0.44 6.81 0.39 6.41e-11 Mean corpuscular volume; CESC cis rs1801251 1.000 rs7587309 chr2:233705702 G/T cg08000102 chr2:233561755 GIGYF2 -0.69 -10.02 -0.52 2.98e-20 Coronary artery disease; CESC trans rs10905099 0.615 rs77158703 chr10:7093576 C/T cg05230642 chr15:25439252 SNORD115-14 -0.73 -6.17 -0.35 2.6e-9 Orofacial clefts; CESC cis rs1008375 1.000 rs4698199 chr4:17656738 G/C cg16339924 chr4:17578868 LAP3 0.56 7.02 0.4 1.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs34779708 0.931 rs4934704 chr10:35332164 C/T cg04310649 chr10:35416472 CREM -0.52 -6.27 -0.36 1.45e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs561341 1.000 rs555629 chr17:30294136 T/C cg12193833 chr17:30244370 NA -0.71 -6.53 -0.37 3.38e-10 Hip circumference adjusted for BMI; CESC cis rs2243480 1.000 rs7795242 chr7:65390094 T/C cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.54 0.54 6.46e-22 Prudent dietary pattern; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15737319 chr2:74425763 MTHFD2 -0.42 -6.05 -0.35 4.84e-9 Gambling; CESC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg08888203 chr3:10149979 C3orf24 0.5 6.02 0.35 5.84e-9 Alzheimer's disease; CESC cis rs12893668 0.542 rs12884809 chr14:104095320 G/A cg08213375 chr14:104286397 PPP1R13B 0.32 5.28 0.31 2.68e-7 Reticulocyte count; CESC cis rs6912958 0.684 rs6931069 chr6:88367082 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -5.77 -0.33 2.19e-8 Monocyte percentage of white cells; CESC cis rs3008870 1.000 rs2985817 chr1:67398607 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs6088580 0.634 rs6059866 chr20:33075810 A/C cg08999081 chr20:33150536 PIGU 0.55 9.46 0.5 1.71e-18 Glomerular filtration rate (creatinine); CESC cis rs3733418 0.860 rs13129396 chr4:165936346 G/A cg10852876 chr4:165953100 TRIM60 -0.49 -5.77 -0.33 2.22e-8 Obesity-related traits; CESC cis rs2075371 1.000 rs2598297 chr7:133993001 T/G cg00033643 chr7:134001901 SLC35B4 0.43 5.42 0.32 1.34e-7 Mean platelet volume; CESC cis rs1153858 1.000 rs10444821 chr15:45647236 C/T cg21132104 chr15:45694354 SPATA5L1 0.84 11.4 0.57 9.5e-25 Homoarginine levels; CESC cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 5.34 0.31 2.05e-7 Axial length; CESC cis rs9291683 0.507 rs3796837 chr4:10011321 C/G cg00071950 chr4:10020882 SLC2A9 0.82 13.78 0.65 5.92e-33 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12090654 chr8:6424636 MCPH1 -0.59 -6.42 -0.37 6.1e-10 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.54 0.54 6.46e-22 Prudent dietary pattern; CESC cis rs258892 0.895 rs13158966 chr5:72059510 C/T cg21869765 chr5:72125136 TNPO1 -0.43 -5.35 -0.31 1.93e-7 Small cell lung carcinoma; CESC cis rs11166629 0.883 rs11778878 chr8:135599220 C/T cg27224718 chr8:135614730 ZFAT -0.47 -5.87 -0.34 1.27e-8 Smoking quantity; CESC cis rs6430585 0.527 rs2254780 chr2:136435526 C/T cg07169764 chr2:136633963 MCM6 0.99 11.95 0.59 1.26e-26 Corneal structure; CESC cis rs9611565 0.802 rs4822028 chr22:41789408 A/G cg03806693 chr22:41940476 POLR3H -1.02 -12.85 -0.62 1.08e-29 Vitiligo; CESC trans rs11098499 0.909 rs17046118 chr4:120387496 T/G cg25214090 chr10:38739885 LOC399744 0.7 9.93 0.52 5.63e-20 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05704155 chr1:10459140 PGD 0.58 6.74 0.38 9.66e-11 Gut microbiome composition (summer); CESC cis rs73019876 0.869 rs10408274 chr19:22144930 C/T cg11619707 chr19:22235551 ZNF257 -0.28 -5.21 -0.3 3.89e-7 Testicular germ cell tumor; CESC cis rs12973672 0.812 rs2280744 chr19:35755386 G/A cg12095397 chr19:35769544 USF2 0.5 5.97 0.34 7.49e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs7980799 0.840 rs7315695 chr12:33551841 G/C cg26384229 chr12:38710491 ALG10B -0.52 -7.04 -0.4 1.64e-11 Heart rate;Heart rate variability traits (RMSSD); CESC trans rs561341 1.000 rs72821971 chr17:30269343 T/G cg20587970 chr11:113659929 NA -1.43 -18.77 -0.76 1.45e-50 Hip circumference adjusted for BMI; CESC cis rs6087990 0.806 rs992472 chr20:31385269 G/T cg13636640 chr20:31349939 DNMT3B 0.84 13.88 0.65 2.71e-33 Ulcerative colitis; CESC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg00149659 chr3:10157352 C3orf10 0.99 11.82 0.59 3.47e-26 Alzheimer's disease; CESC cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg10556349 chr10:835070 NA 0.54 5.27 0.31 2.78e-7 Eosinophil percentage of granulocytes; CESC cis rs60843830 1.000 rs62114548 chr2:274672 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.89 11.87 0.59 2.49e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs117623576 0.941 rs16932939 chr10:32407862 T/C cg03047570 chr10:32398778 NA -0.84 -8.6 -0.47 7.18e-16 Anti-saccade response; CESC cis rs6540559 0.611 rs76766079 chr1:209997731 C/T cg25204440 chr1:209979598 IRF6 0.68 6.57 0.37 2.59e-10 Cleft lip with or without cleft palate; CESC cis rs823128 1.000 rs823128 chr1:205713378 G/A cg13473505 chr1:205738393 RAB7L1 0.69 5.76 0.33 2.35e-8 Parkinson's disease; CESC cis rs4664308 0.935 rs6739867 chr2:160942818 G/A cg03641300 chr2:160917029 PLA2R1 -0.67 -9.84 -0.52 1.11e-19 Idiopathic membranous nephropathy; CESC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg05368731 chr17:41323189 NBR1 0.8 10.6 0.55 3.93e-22 Menopause (age at onset); CESC cis rs4566357 0.615 rs3769642 chr2:227917323 T/C cg05526886 chr2:227700861 RHBDD1 -0.52 -6.83 -0.39 5.73e-11 Coronary artery disease; CESC cis rs2463822 0.844 rs7104149 chr11:62171627 A/G cg06239285 chr11:62104954 ASRGL1 -0.89 -7.75 -0.43 1.92e-13 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs3785574 0.621 rs1051684 chr17:62006497 A/G cg06873352 chr17:61820015 STRADA -0.36 -5.21 -0.3 3.83e-7 Height; CESC cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg00033643 chr7:134001901 SLC35B4 0.44 5.78 0.33 2.04e-8 Mean platelet volume; CESC cis rs72829446 0.530 rs4796420 chr17:7379617 A/T cg02795151 chr17:7402630 POLR2A 0.53 5.74 0.33 2.52e-8 Androgen levels; CESC cis rs8072100 0.713 rs4968257 chr17:45430534 A/G cg25173405 chr17:45401733 C17orf57 -0.44 -5.48 -0.32 9.98e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1707322 0.662 rs11211160 chr1:46146229 T/A cg05343316 chr1:45956843 TESK2 0.52 6.43 0.37 5.88e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6582630 0.519 rs7305545 chr12:38349223 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.95 0.56 2.81e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs2832191 0.636 rs8131295 chr21:30516819 A/T cg08807101 chr21:30365312 RNF160 -0.56 -6.46 -0.37 4.91e-10 Dental caries; CESC cis rs6964587 0.782 rs13221571 chr7:91500236 C/T cg17063962 chr7:91808500 NA -0.53 -7.23 -0.41 5.15e-12 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20044168 chr6:87865051 ZNF292 0.57 6.3 0.36 1.26e-9 Gut microbiome composition (summer); CESC cis rs3820928 0.605 rs10186145 chr2:227781150 A/G cg11843606 chr2:227700838 RHBDD1 -0.59 -8.4 -0.46 2.68e-15 Pulmonary function; CESC trans rs9319321 0.592 rs1927510 chr13:27416616 G/C cg14332112 chr6:47277683 TNFRSF21 -0.49 -6.22 -0.36 1.97e-9 Asthma (toluene diisocyanate-induced); CESC cis rs546131 0.963 rs539044 chr11:34841542 G/T cg11058730 chr11:34937778 PDHX;APIP 0.49 6.38 0.36 7.87e-10 Lung disease severity in cystic fibrosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27100149 chr18:77196899 NFATC1 -0.43 -6.67 -0.38 1.5e-10 Gut microbiota (bacterial taxa); CESC cis rs72781680 0.716 rs2551343 chr2:24027002 C/G cg08917208 chr2:24149416 ATAD2B 0.61 5.99 0.35 6.74e-9 Lymphocyte counts; CESC cis rs6831352 0.734 rs3018046 chr4:100030388 C/T cg12011299 chr4:100065546 ADH4 0.57 6.88 0.39 4.34e-11 Alcohol dependence; CESC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg24675658 chr1:53192096 ZYG11B 0.62 7.68 0.43 3.04e-13 Monocyte count; CESC cis rs763121 0.853 rs7289577 chr22:39042214 C/G cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC cis rs11792861 0.890 rs3087979 chr9:111781779 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.47 5.98 0.34 7.2e-9 Menarche (age at onset); CESC cis rs2354432 0.607 rs58941651 chr1:146784919 T/C cg25205988 chr1:146714368 CHD1L -1.0 -8.9 -0.48 9.01e-17 Mitochondrial DNA levels; CESC cis rs561341 0.882 rs111484028 chr17:30287701 G/A cg19193384 chr17:30244184 NA -0.61 -6.41 -0.37 6.51e-10 Hip circumference adjusted for BMI; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05611199 chr16:88637223 ZC3H18 -0.47 -6.12 -0.35 3.33e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21318521 chr6:107349259 C6orf203 0.58 7.02 0.4 1.83e-11 Gut microbiome composition (summer); CESC cis rs3925075 0.764 rs8044482 chr16:31345752 T/C cg02846316 chr16:31340340 ITGAM 0.41 6.49 0.37 4.24e-10 IgA nephropathy; CESC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg19774624 chr17:42201019 HDAC5 -0.66 -9.67 -0.51 3.77e-19 Total body bone mineral density; CESC trans rs4471313 1.000 rs861121 chr1:170354106 G/A cg14876685 chr7:99177937 NA -0.41 -6.21 -0.36 2.03e-9 Waist-hip ratio; CESC cis rs2635047 0.935 rs2576031 chr18:44658146 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.77 0.38 8.5e-11 Educational attainment; CESC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg08470875 chr2:26401718 FAM59B 0.75 7.79 0.43 1.49e-13 Gut microbiome composition (summer); CESC trans rs1814175 0.616 rs1722020 chr11:49904189 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg04414720 chr1:150670196 GOLPH3L 0.45 5.95 0.34 8.27e-9 Melanoma; CESC cis rs941408 0.515 rs1736188 chr19:2782368 A/G cg00079169 chr19:2811669 THOP1 0.37 5.16 0.3 4.77e-7 Total cholesterol levels; CESC cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg16928487 chr17:17741425 SREBF1 -0.53 -8.87 -0.48 1.11e-16 Total body bone mineral density; CESC cis rs11098499 0.644 rs10050092 chr4:120532085 T/C cg09307838 chr4:120376055 NA 0.74 10.02 0.52 2.95e-20 Corneal astigmatism; CESC cis rs914615 0.507 rs4971085 chr1:155138222 T/C cg02153340 chr1:155202674 NA -0.38 -5.59 -0.32 5.57e-8 Urinary albumin-to-creatinine ratio; CESC cis rs660498 0.507 rs12413784 chr10:27729599 C/G cg08398567 chr10:27609333 NA 0.39 5.39 0.31 1.6e-7 Asthma (childhood onset); CESC cis rs4808199 1.000 rs60321073 chr19:19499598 A/G cg03709012 chr19:19516395 GATAD2A 1.13 13.27 0.63 3.7e-31 Nonalcoholic fatty liver disease; CESC cis rs6076065 0.802 rs2424527 chr20:23357329 A/C cg11657817 chr20:23433608 CST11 0.42 6.36 0.36 8.95e-10 Facial morphology (factor 15, philtrum width); CESC cis rs6500395 1.000 rs2129243 chr16:48646852 A/T cg04672837 chr16:48644449 N4BP1 0.49 5.79 0.34 1.97e-8 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08365438 chr10:21683093 NA -0.75 -9.21 -0.49 1.04e-17 Gut microbiome composition (summer); CESC cis rs425277 0.585 rs3128294 chr1:2065343 G/C cg04315214 chr1:2043799 PRKCZ 0.51 8.2 0.45 1.03e-14 Height; CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg23978390 chr7:1156363 C7orf50 0.53 7.14 0.4 8.89e-12 Longevity;Endometriosis; CESC trans rs634534 0.562 rs642293 chr11:65730217 G/A cg17712092 chr4:129076599 LARP1B 0.7 9.65 0.51 4.44e-19 Sum eosinophil basophil counts;Eosinophil counts; CESC trans rs722599 0.748 rs1059326 chr14:75369385 C/T cg00095594 chr1:236228625 NID1 -0.4 -6.19 -0.36 2.31e-9 IgG glycosylation; CESC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg06456125 chr7:65229604 NA 0.45 5.83 0.34 1.57e-8 Calcium levels; CESC cis rs1808579 0.904 rs1788783 chr18:21161134 C/T cg14672496 chr18:21087552 C18orf8 0.37 5.25 0.31 3.07e-7 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs734999 0.572 rs4310388 chr1:2507415 G/T cg20673091 chr1:2541236 MMEL1 0.41 6.75 0.38 9.34e-11 Ulcerative colitis; CESC cis rs9467711 0.538 rs35934643 chr6:26355094 G/A cg14345882 chr6:26364793 BTN3A2 0.6 6.29 0.36 1.33e-9 Autism spectrum disorder or schizophrenia; CESC cis rs4450798 0.793 rs9831150 chr3:13740916 C/T cg05589046 chr3:13742034 LOC285375 0.37 5.49 0.32 9.59e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs2439831 0.850 rs28684672 chr15:44107662 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.69 0.43 2.87e-13 Lung cancer in ever smokers; CESC cis rs3806843 0.735 rs778595 chr5:140036681 G/A cg16179182 chr5:140090404 VTRNA1-1 0.41 5.39 0.31 1.55e-7 Depressive symptoms (multi-trait analysis); CESC trans rs1994135 0.549 rs2218650 chr12:33734783 A/G cg26384229 chr12:38710491 ALG10B 0.44 6.29 0.36 1.28e-9 Resting heart rate; CESC cis rs11792861 0.781 rs11789252 chr9:111762010 A/T cg05043794 chr9:111880884 C9orf5 -0.38 -6.14 -0.35 2.93e-9 Menarche (age at onset); CESC cis rs7084402 0.935 rs1658492 chr10:60281267 C/T cg07615347 chr10:60278583 BICC1 -0.59 -9.48 -0.5 1.48e-18 Refractive error; CESC cis rs11864453 0.647 rs10492813 chr16:72122463 A/G cg16558253 chr16:72132732 DHX38 0.53 8.27 0.45 6.34e-15 Fibrinogen levels; CESC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.75 7.09 0.4 1.25e-11 Platelet count; CESC cis rs11638352 1.000 rs8038096 chr15:44367290 A/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.47 -5.25 -0.31 3.12e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs8062405 0.690 rs62034351 chr16:28565489 G/A cg07382826 chr16:28625726 SULT1A1 0.39 6.35 0.36 9.44e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.49 6.74 0.38 1e-10 Bipolar disorder; CESC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg08736216 chr1:53307985 ZYG11A -0.41 -6.84 -0.39 5.46e-11 Monocyte count; CESC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.64 0.38 1.8e-10 Bipolar disorder; CESC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg08470875 chr2:26401718 FAM59B -0.67 -7.46 -0.42 1.25e-12 Gut microbiome composition (summer); CESC cis rs27434 0.583 rs40091 chr5:96154919 A/G cg16492584 chr5:96139282 ERAP1 -0.37 -5.46 -0.32 1.09e-7 Ankylosing spondylitis; CESC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.32 0.46 4.71e-15 Menopause (age at onset); CESC cis rs757110 0.868 rs5219 chr11:17409572 T/C cg11839944 chr11:17409644 KCNJ11 0.39 5.18 0.3 4.49e-7 Type 2 diabetes; CESC cis rs704 0.585 rs2227735 chr17:26693258 C/T cg10494684 chr17:26645200 TMEM97 -0.38 -5.32 -0.31 2.25e-7 Osteoprotegerin levels; CESC trans rs12492269 0.702 rs41381644 chr3:178161614 A/G cg24455024 chr3:179370471 USP13 -0.71 -6.06 -0.35 4.54e-9 Plasma clusterin levels; CESC cis rs2243480 1.000 rs6964245 chr7:65718717 G/A cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs524281 0.861 rs7124165 chr11:65901218 C/T cg14036092 chr11:66035641 RAB1B -0.58 -5.84 -0.34 1.5e-8 Electroencephalogram traits; CESC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg04267008 chr7:1944627 MAD1L1 -0.73 -9.35 -0.5 3.82e-18 Bipolar disorder and schizophrenia; CESC cis rs3015497 0.570 rs2934679 chr14:51093745 C/T cg26011998 chr14:51135199 SAV1 0.47 5.16 0.3 4.8e-7 Mean platelet volume; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg10632811 chr17:45918739 SCRN2 -0.54 -6.28 -0.36 1.37e-9 Subjective well-being; CESC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg05863683 chr7:1912471 MAD1L1 0.38 5.54 0.32 7.31e-8 Bipolar disorder and schizophrenia; CESC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg26314531 chr2:26401878 FAM59B 0.83 8.36 0.46 3.57e-15 Gut microbiome composition (summer); CESC cis rs826838 0.620 rs11614695 chr12:39331847 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.51 0.37 3.66e-10 Heart rate; CESC cis rs2235642 0.928 rs2076435 chr16:1607574 C/T cg08296037 chr16:1584118 IFT140;TMEM204 -0.31 -5.21 -0.3 3.88e-7 Coronary artery disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10823546 chr9:88555702 NAA35 -0.46 -6.05 -0.35 4.79e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4481887 1.000 rs4489592 chr1:248470697 A/T cg00666640 chr1:248458726 OR2T12 0.4 6.57 0.37 2.7e-10 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06096994 chr13:41635664 WBP4 0.6 7.3 0.41 3.42e-12 Gut microbiome composition (summer); CESC trans rs801193 1.000 rs2659909 chr7:66160279 G/A cg26939375 chr7:64535504 NA 0.66 8.84 0.48 1.4e-16 Aortic root size; CESC cis rs6499255 1.000 rs4078387 chr16:69814047 G/A cg15192750 chr16:69999425 NA 0.46 5.64 0.33 4.46e-8 IgE levels; CESC cis rs67311347 0.955 rs60554147 chr3:40472503 T/C cg09455208 chr3:40491958 NA 0.44 7.56 0.42 6.51e-13 Renal cell carcinoma; CESC cis rs1475911 1.000 rs2839465 chr21:43511232 C/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.55 6.26 0.36 1.52e-9 IgG glycosylation; CESC cis rs12711979 0.509 rs10181286 chr2:3824567 G/A cg17052675 chr2:3827356 NA -0.66 -11.02 -0.56 1.71e-23 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs4234798 0.500 rs10937793 chr4:7219614 C/T cg18431297 chr4:7219810 SORCS2 0.56 9.37 0.5 3.28e-18 Insulin-like growth factors; CESC cis rs7605827 0.930 rs7596435 chr2:15605091 T/C cg19274914 chr2:15703543 NA 0.36 6.42 0.37 6.17e-10 Educational attainment (years of education); CESC trans rs9944275 0.860 rs34769936 chr15:97191343 T/C cg26794346 chr6:16472305 ATXN1 0.73 6.06 0.35 4.65e-9 Depressive symptoms (multi-trait analysis);Neuroticism (multi-trait analysis); CESC cis rs6964587 0.692 rs2299233 chr7:91626953 C/T cg17063962 chr7:91808500 NA -0.46 -6.67 -0.38 1.5e-10 Breast cancer; CESC cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg21138405 chr5:131827807 IRF1 0.54 9.32 0.5 4.74e-18 Asthma (sex interaction); CESC cis rs2932538 0.922 rs12758377 chr1:113137221 C/A cg22162597 chr1:113214053 CAPZA1 0.55 7.11 0.4 1.1e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg16325326 chr1:53192061 ZYG11B 0.9 16.12 0.7 3.36e-41 Monocyte count; CESC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg26338869 chr17:61819248 STRADA 0.69 8.92 0.48 7.86e-17 Prudent dietary pattern; CESC cis rs9325144 0.624 rs7312879 chr12:39150752 G/A cg26384229 chr12:38710491 ALG10B -0.51 -7.05 -0.4 1.59e-11 Morning vs. evening chronotype; CESC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg01341218 chr17:43662625 NA -0.55 -7.38 -0.41 1.99e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg16339924 chr4:17578868 LAP3 0.59 7.4 0.41 1.83e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6580649 0.825 rs4760611 chr12:48421449 A/G cg05342945 chr12:48394962 COL2A1 -0.53 -6.21 -0.36 2.09e-9 Lung cancer; CESC cis rs870825 0.655 rs28726376 chr4:185638954 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.07 0.4 1.39e-11 Blood protein levels; CESC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 7.95 0.44 5.36e-14 Platelet count; CESC cis rs9788682 1.000 rs34138960 chr15:78831668 A/G cg24631222 chr15:78858424 CHRNA5 0.81 10.53 0.54 6.79e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg07870213 chr5:140052090 DND1 0.64 6.81 0.39 6.47e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3749237 1.000 rs2291542 chr3:49751585 C/T cg03060546 chr3:49711283 APEH 0.56 6.72 0.38 1.11e-10 Resting heart rate; CESC cis rs7267979 0.844 rs2257649 chr20:25263457 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 14.52 0.67 1.49e-35 Liver enzyme levels (alkaline phosphatase); CESC cis rs7274811 0.744 rs6119395 chr20:32244711 G/T cg21523528 chr20:32077966 CBFA2T2 0.57 6.58 0.37 2.47e-10 Height; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg22515636 chr2:109150313 NA 0.5 6.56 0.37 2.85e-10 Systemic lupus erythematosus; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19831303 chr11:64126461 RPS6KA4 -0.43 -6.29 -0.36 1.28e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs854765 0.552 rs11078407 chr17:17841083 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.71 0.47 3.29e-16 Total body bone mineral density; CESC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg24503407 chr1:205819492 PM20D1 -0.45 -6.16 -0.35 2.76e-9 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs1691799 0.867 rs1168347 chr12:66757303 T/C cg16791601 chr12:66731901 HELB -0.62 -10.09 -0.53 1.79e-20 White blood cell count (basophil); CESC cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs1062177 0.950 rs892005 chr5:151180621 A/G cg12924095 chr5:151150029 G3BP1 0.49 6.44 0.37 5.67e-10 Preschool internalizing problems; CESC cis rs751837 0.591 rs9806052 chr14:103417519 T/G cg10087771 chr14:103399429 CDC42BPB 0.6 5.55 0.32 6.86e-8 Large B-cell lymphoma; CESC cis rs2235642 0.821 rs8051895 chr16:1602811 A/G cg07639376 chr16:1584516 IFT140;TMEM204 -0.31 -5.07 -0.3 7.41e-7 Coronary artery disease; CESC cis rs4812048 0.649 rs3761255 chr20:57618802 T/C cg14073986 chr20:57617431 SLMO2 0.79 6.96 0.39 2.61e-11 Mean platelet volume; CESC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.35 -0.5 3.75e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1215050 0.791 rs1530904 chr4:98805436 A/G cg05340658 chr4:99064831 C4orf37 0.52 6.88 0.39 4.36e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.3 -0.5 5.54e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9303401 0.614 rs34900851 chr17:56566399 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.08 0.6 4.54e-27 Cognitive test performance; CESC cis rs1707322 1.000 rs4660336 chr1:46487976 T/C cg05343316 chr1:45956843 TESK2 -0.44 -5.38 -0.31 1.66e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg27266027 chr21:40555129 PSMG1 0.46 5.43 0.32 1.27e-7 Cognitive function; CESC cis rs11792861 0.926 rs7046725 chr9:111882729 T/G cg13535736 chr9:111863775 C9orf5 -0.5 -6.68 -0.38 1.43e-10 Menarche (age at onset); CESC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.23 0.53 6.6e-21 Prudent dietary pattern; CESC cis rs6662572 1.000 rs28433203 chr1:46196813 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 5.45 0.32 1.17e-7 Blood protein levels; CESC cis rs2735413 0.837 rs4888734 chr16:78083685 C/G cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7927592 0.731 rs488381 chr11:68291693 G/A cg16797656 chr11:68205561 LRP5 -0.49 -7.54 -0.42 7.54e-13 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07785726 chr13:50159788 RCBTB1 0.54 6.33 0.36 1.04e-9 Gut microbiome composition (summer); CESC cis rs2180341 0.618 rs11961994 chr6:127649350 A/G cg24812749 chr6:127587940 RNF146 -0.59 -7.92 -0.44 6.62e-14 Breast cancer; CESC cis rs4595586 0.545 rs4254106 chr12:39389342 G/A cg26384229 chr12:38710491 ALG10B 0.53 7.55 0.42 6.93e-13 Morning vs. evening chronotype; CESC cis rs910316 0.737 rs424120 chr14:75482828 G/T cg11812906 chr14:75593930 NEK9 -0.81 -13.05 -0.63 2.11e-30 Height; CESC cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg04455712 chr21:45112962 RRP1B 0.39 5.76 0.33 2.35e-8 Mean corpuscular volume; CESC cis rs2735413 0.918 rs4888725 chr16:78076761 C/T cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18958584 chr17:18266764 SHMT1 0.64 7.31 0.41 3.14e-12 Gut microbiome composition (summer); CESC cis rs10927875 0.632 rs7535248 chr1:16129598 C/T cg21385522 chr1:16154831 NA -1.03 -16.9 -0.72 5.51e-44 Dilated cardiomyopathy; CESC cis rs8002861 0.692 rs9533646 chr13:44410669 T/C cg19180546 chr13:44453867 C13orf31;CCDC122 -0.39 -5.11 -0.3 6.03e-7 Leprosy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25011051 chr17:40718249 MLX;COASY 0.46 6.66 0.38 1.54e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg11166453 chr1:247681781 NA 0.47 6.33 0.36 1.05e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg03709012 chr19:19516395 GATAD2A 0.96 13.77 0.65 6.58e-33 Tonsillectomy; CESC cis rs2637266 1.000 rs12262400 chr10:78386862 T/C cg18941641 chr10:78392320 NA 0.43 8.21 0.45 9.73e-15 Pulmonary function; CESC cis rs477692 1.000 rs508303 chr10:131424996 A/T cg05714579 chr10:131428358 MGMT -0.53 -7.11 -0.4 1.09e-11 Response to temozolomide; CESC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg08499158 chr17:42289980 UBTF -0.52 -6.57 -0.37 2.68e-10 Total body bone mineral density; CESC cis rs4835473 0.864 rs4835343 chr4:144787191 A/C cg25736465 chr4:144833511 NA 0.44 6.58 0.37 2.48e-10 Immature fraction of reticulocytes; CESC cis rs889312 0.500 rs33323 chr5:56175566 C/G cg14703610 chr5:56206110 C5orf35 0.48 6.22 0.36 1.96e-9 Breast cancer;Breast cancer (early onset); CESC cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg11812906 chr14:75593930 NEK9 -0.85 -14.19 -0.66 2.25e-34 Height; CESC cis rs6547741 0.563 rs10196039 chr2:27971195 C/T cg27432699 chr2:27873401 GPN1 -0.55 -7.6 -0.42 5.08e-13 Oral cavity cancer; CESC cis rs7208859 0.673 rs2470251 chr17:29095061 T/C cg14008862 chr17:28927542 LRRC37B2 0.56 5.24 0.31 3.36e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs796364 0.951 rs281793 chr2:200847990 G/A cg23649088 chr2:200775458 C2orf69 0.55 5.16 0.3 4.74e-7 Schizophrenia; CESC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.92 0.34 1.01e-8 Tonsillectomy; CESC cis rs67478160 0.619 rs11160761 chr14:104254856 A/T cg08213375 chr14:104286397 PPP1R13B 0.55 10.84 0.55 6.53e-23 Schizophrenia; CESC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg02807482 chr3:125708958 NA -0.4 -5.2 -0.3 3.94e-7 Blood pressure (smoking interaction); CESC cis rs3733585 0.699 rs4276278 chr4:9948870 T/C cg00071950 chr4:10020882 SLC2A9 -0.72 -11.95 -0.59 1.27e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs763121 1.000 rs86796 chr22:38881454 A/C cg06022373 chr22:39101656 GTPBP1 -0.7 -10.45 -0.54 1.22e-21 Menopause (age at onset); CESC cis rs2191566 0.960 rs6509133 chr19:44522913 A/G cg20607764 chr19:44506953 ZNF230 0.56 7.11 0.4 1.07e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg05585544 chr11:47624801 NA 0.42 6.19 0.36 2.33e-9 Subjective well-being; CESC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -7.32 -0.41 3e-12 Developmental language disorder (linguistic errors); CESC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg18240062 chr17:79603768 NPLOC4 -0.54 -7.2 -0.4 6.24e-12 Eye color traits; CESC cis rs3741798 1.000 rs61922052 chr12:12497620 A/G cg08615371 chr12:12503544 MANSC1 0.79 5.65 0.33 4.22e-8 Cerebrospinal fluid biomarker levels; CESC cis rs10788264 0.621 rs9633734 chr10:124057667 T/C cg09507567 chr10:124027408 NA 0.36 5.23 0.31 3.5e-7 Total body bone mineral density; CESC cis rs6912958 0.559 rs242281 chr6:88048916 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.44 7.8 0.43 1.47e-13 Monocyte percentage of white cells; CESC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs6831352 0.918 rs7670241 chr4:100059619 G/T cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs617791 0.508 rs10896074 chr11:65776304 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.48 -5.39 -0.31 1.58e-7 Breast cancer; CESC cis rs4986811 0.852 rs72893517 chr11:32451921 G/C cg27409910 chr11:32454216 WT1 0.48 6.2 0.36 2.18e-9 Rubella-specific interleukin-6 secretion; CESC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg08470875 chr2:26401718 FAM59B -0.47 -5.24 -0.31 3.31e-7 Gut microbiome composition (summer); CESC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg04025307 chr7:1156635 C7orf50 0.4 6.39 0.37 7.38e-10 Longevity;Endometriosis; CESC cis rs9894429 0.752 rs6565610 chr17:79592652 A/G cg18240062 chr17:79603768 NPLOC4 0.9 13.2 0.63 6.66e-31 Eye color traits; CESC cis rs4642101 0.765 rs4321514 chr3:12825901 C/T cg05775895 chr3:12838266 CAND2 0.39 5.99 0.35 6.95e-9 QRS complex (12-leadsum); CESC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg08308459 chr2:38893161 GALM -0.54 -6.72 -0.38 1.12e-10 5-HTT brain serotonin transporter levels; CESC cis rs8017423 0.967 rs55667096 chr14:90714798 C/T cg14092571 chr14:90743983 NA -0.58 -8.66 -0.47 4.57e-16 Mortality in heart failure; CESC cis rs4481887 1.000 rs9660769 chr1:248484558 C/G cg00666640 chr1:248458726 OR2T12 -0.43 -7.07 -0.4 1.37e-11 Common traits (Other); CESC cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.99 0.56 2.18e-23 Hip circumference adjusted for BMI; CESC cis rs7267979 0.873 rs7453 chr20:25207074 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.81 16.14 0.7 2.75e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs763121 0.853 rs1043441 chr22:39130964 C/T cg14440974 chr22:39074834 NA -0.4 -5.55 -0.32 6.82e-8 Menopause (age at onset); CESC cis rs7818345 0.967 rs7006702 chr8:19272533 G/C cg11303988 chr8:19266685 CSGALNACT1 0.34 6.03 0.35 5.51e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs7044106 0.762 rs966397 chr9:123453312 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.83 0.34 1.58e-8 Hip circumference adjusted for BMI; CESC cis rs1401999 0.565 rs4912515 chr3:183653718 A/G cg01324343 chr3:183735012 ABCC5 0.34 6.14 0.35 2.93e-9 Anterior chamber depth; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25793566 chr3:196467045 PAK2 0.52 6.24 0.36 1.75e-9 Gut microbiome composition (summer); CESC cis rs9908102 0.710 rs4792314 chr17:12918451 G/A cg26162695 chr17:12921313 ELAC2 0.56 6.04 0.35 5.13e-9 Schizophrenia; CESC cis rs938554 0.735 rs11942223 chr4:9962765 T/C cg00071950 chr4:10020882 SLC2A9 -0.52 -6.04 -0.35 5.3300000000000004e-09 Blood metabolite levels; CESC trans rs17685 0.712 rs11770149 chr7:75791644 G/A cg19862616 chr7:65841803 NCRNA00174 0.79 11.08 0.56 1.09e-23 Coffee consumption;Coffee consumption (cups per day); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12933314 chr7:4815160 KIAA0415 -0.5 -7.48 -0.42 1.09e-12 Gambling; CESC cis rs2573652 0.722 rs12914189 chr15:100544429 A/T cg09918751 chr15:100517450 ADAMTS17 0.27 5.13 0.3 5.64e-7 Height; CESC cis rs6456156 0.586 rs12203510 chr6:167473006 C/T cg23791538 chr6:167370224 RNASET2 -0.48 -6.0 -0.35 6.29e-9 Primary biliary cholangitis; CESC cis rs10465746 0.905 rs12127266 chr1:84360767 T/G cg10977910 chr1:84465055 TTLL7 0.47 6.36 0.36 8.7e-10 Obesity-related traits; CESC cis rs6598955 0.670 rs7531518 chr1:26539749 T/C cg00852783 chr1:26633632 UBXN11 0.41 5.97 0.34 7.44e-9 Obesity-related traits; CESC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg13607699 chr17:42295918 UBTF 0.57 7.14 0.4 8.93e-12 Total body bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11814422 chr18:47018265 SNORD58A;RPL17;SNORD58B 0.47 6.18 0.35 2.46e-9 Gut microbiota (bacterial taxa); CESC cis rs3762637 1.000 rs72960431 chr3:122228661 T/C cg24169773 chr3:122142474 KPNA1 -0.57 -6.98 -0.39 2.36e-11 LDL cholesterol levels; CESC cis rs1322639 0.592 rs7743597 chr6:169591678 T/C cg04662567 chr6:169592167 NA -0.43 -6.12 -0.35 3.42e-9 Pulse pressure; CESC cis rs2364543 0.624 rs61774752 chr1:41847024 T/C cg08462924 chr1:41848221 NA 0.43 6.0 0.35 6.55e-9 Intelligence (multi-trait analysis); CESC cis rs11758351 0.660 rs55848726 chr6:26224434 T/C cg01420254 chr6:26195488 NA 0.77 8.49 0.46 1.48e-15 Gout;Renal underexcretion gout; CESC cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg01830674 chr2:219433148 RQCD1;USP37 -0.41 -6.21 -0.36 2.01e-9 Breast cancer; CESC cis rs116979167 0.575 rs818470 chr7:105165350 A/C cg13798780 chr7:105162888 PUS7 0.53 6.41 0.37 6.67e-10 Bipolar disorder (body mass index interaction); CESC cis rs977987 0.806 rs8056236 chr16:75448273 C/T cg03315344 chr16:75512273 CHST6 0.41 5.81 0.34 1.79e-8 Dupuytren's disease; CESC cis rs4595586 0.545 rs7294600 chr12:39373416 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC trans rs8073060 0.586 rs225256 chr17:33955756 C/T cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs763121 0.626 rs5750643 chr22:39009017 A/G cg21395723 chr22:39101663 GTPBP1 0.51 6.76 0.38 8.67e-11 Menopause (age at onset); CESC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg17414380 chr19:19431394 KIAA0892;SF4 0.51 6.38 0.36 8.06e-10 Tonsillectomy; CESC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.19 -0.3 4.29e-7 Developmental language disorder (linguistic errors); CESC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg15369054 chr17:80825471 TBCD 0.55 7.76 0.43 1.89e-13 Breast cancer; CESC cis rs6540556 0.859 rs1007693 chr1:209931799 C/T cg05527609 chr1:210001259 C1orf107 -0.45 -5.72 -0.33 2.86e-8 Red blood cell count; CESC cis rs1538970 0.924 rs7528573 chr1:45913860 T/C cg24296786 chr1:45957014 TESK2 -0.46 -5.25 -0.31 3.14e-7 Platelet count; CESC cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.85 0.34 1.45e-8 Colorectal cancer; CESC cis rs2463822 0.925 rs6863 chr11:62160725 G/T cg06239285 chr11:62104954 ASRGL1 -1.0 -8.65 -0.47 5.18e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs74781061 0.722 rs77102700 chr15:74896941 G/A cg17294928 chr15:75287854 SCAMP5 -0.54 -5.35 -0.31 1.94e-7 Endometriosis; CESC cis rs1008375 1.000 rs11724495 chr4:17621310 G/A cg02297831 chr4:17616191 MED28 0.53 6.71 0.38 1.16e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs17739794 0.557 rs7816977 chr8:814612 A/G cg07178994 chr8:816998 NA 0.29 5.08 0.3 7.12e-7 Clozapine-induced cytotoxicity; CESC cis rs2249694 0.960 rs11101890 chr10:135421321 G/A cg19469447 chr10:135341870 CYP2E1 0.37 5.2 0.3 3.99e-7 Obesity-related traits; CESC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.82 0.55 7.67e-23 Alzheimer's disease; CESC cis rs5758659 0.652 rs133347 chr22:42423645 A/T cg15557168 chr22:42548783 NA -0.48 -7.56 -0.42 6.56e-13 Cognitive function; CESC cis rs7520050 0.931 rs35743647 chr1:46407252 T/C cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.64e-8 Red blood cell count;Reticulocyte count; CESC cis rs4253772 0.591 rs9615348 chr22:46729338 C/G cg24881330 chr22:46731750 TRMU 0.8 5.7 0.33 3.13e-8 LDL cholesterol;Cholesterol, total; CESC cis rs8028182 1.000 rs8028182 chr15:75718669 G/T cg20655648 chr15:75932815 IMP3 0.46 5.3 0.31 2.44e-7 Sudden cardiac arrest; CESC cis rs2295499 0.700 rs12503424 chr4:2702807 A/G cg27239842 chr4:2403781 ZFYVE28 -0.32 -5.32 -0.31 2.2e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs9486719 0.947 rs72932805 chr6:96902933 T/G cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.45e-15 Migraine;Coronary artery disease; CESC cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg05340658 chr4:99064831 C4orf37 0.63 9.73 0.51 2.42e-19 Colonoscopy-negative controls vs population controls; CESC cis rs9900062 0.519 rs2676293 chr17:62710461 T/C cg02598441 chr17:62777298 LOC146880 -0.49 -5.19 -0.3 4.21e-7 QT interval; CESC cis rs601339 1.000 rs35683065 chr12:123164062 G/C cg11919336 chr12:123188078 GPR109A 0.45 5.85 0.34 1.47e-8 Adiponectin levels; CESC cis rs7772486 0.623 rs735535 chr6:146036829 C/T cg23711669 chr6:146136114 FBXO30 -0.89 -13.19 -0.63 6.74e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg11812906 chr14:75593930 NEK9 -0.82 -13.42 -0.64 1.14e-31 Height; CESC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg11644478 chr21:40555479 PSMG1 -0.56 -7.65 -0.43 3.72e-13 Menarche (age at onset); CESC cis rs6942756 0.747 rs691124 chr7:129098439 A/G cg02491457 chr7:128862824 NA -0.59 -8.05 -0.44 2.79e-14 White matter hyperintensity burden; CESC cis rs8114671 0.836 rs2104083 chr20:33649133 G/A cg06115741 chr20:33292138 TP53INP2 -0.43 -5.15 -0.3 5.03e-7 Height; CESC cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg10819733 chr22:24237672 NA -0.44 -6.34 -0.36 1e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12368653 0.557 rs903067 chr12:58011857 G/A cg00700412 chr12:58011837 NA -0.43 -6.61 -0.38 2.11e-10 Multiple sclerosis; CESC cis rs9549367 0.789 rs12584008 chr13:113881228 C/T cg00898013 chr13:113819073 PROZ -0.5 -6.9 -0.39 3.77e-11 Platelet distribution width; CESC cis rs6690583 0.573 rs61768854 chr1:85460021 T/C cg22153463 chr1:85462885 MCOLN2 0.76 7.2 0.4 6.15e-12 Serum sulfate level; CESC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.39 -0.37 7.41e-10 Parkinson's disease; CESC cis rs7116495 0.609 rs10793014 chr11:71698838 A/G cg10381502 chr11:71823885 C11orf51 -1.19 -7.81 -0.43 1.32e-13 Severe influenza A (H1N1) infection; CESC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.18 0.4 6.94e-12 Electroencephalogram traits; CESC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg01570182 chr17:44337453 NA 0.61 7.34 0.41 2.57e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4595586 0.545 rs17546137 chr12:39401124 G/A cg26384229 chr12:38710491 ALG10B 0.62 8.72 0.47 3.18e-16 Morning vs. evening chronotype; CESC cis rs9486719 0.741 rs2049927 chr6:96848958 C/G cg18709589 chr6:96969512 KIAA0776 -0.5 -5.36 -0.31 1.83e-7 Migraine;Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15252948 chr8:42698594 THAP1 0.54 6.09 0.35 4.02e-9 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs78386830 chr14:56069224 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg11764359 chr7:65958608 NA -0.92 -14.72 -0.67 2.89e-36 Aortic root size; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09249682 chr7:17338253 AHR 0.47 6.0 0.35 6.4e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1005224 0.853 rs2360035 chr14:76297093 A/T cg25116370 chr14:76127843 TTLL5;C14orf1 0.44 5.88 0.34 1.2e-8 Large artery stroke; CESC cis rs12477438 0.501 rs13033012 chr2:99795149 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 12.45 0.61 2.6e-28 Chronic sinus infection; CESC cis rs793571 0.590 rs442495 chr15:59022615 T/C cg05156742 chr15:59063176 FAM63B 0.58 7.69 0.43 2.96e-13 Schizophrenia; CESC cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg10556349 chr10:835070 NA 0.55 5.25 0.31 3.05e-7 Eosinophil percentage of granulocytes; CESC cis rs1801251 0.778 rs778338 chr2:233740227 A/G cg25237894 chr2:233734115 C2orf82 -0.5 -8.81 -0.48 1.65e-16 Coronary artery disease; CESC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg15052019 chr19:19431593 KIAA0892;SF4 -0.4 -5.09 -0.3 6.73e-7 Tonsillectomy; CESC cis rs10791097 0.694 rs1893017 chr11:130756253 C/T cg12179176 chr11:130786555 SNX19 0.66 10.36 0.54 2.45e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11630290 0.592 rs12232261 chr15:64153302 A/G cg12036633 chr15:63758958 NA 0.46 5.67 0.33 3.82e-8 Iris characteristics; CESC cis rs4595586 0.525 rs4511319 chr12:39340457 T/C cg26384229 chr12:38710491 ALG10B 0.45 6.38 0.36 7.93e-10 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13369981 chr7:100027501 MEPCE;ZCWPW1 -0.45 -7.17 -0.4 7.56e-12 Gambling; CESC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg14893161 chr1:205819251 PM20D1 0.89 14.24 0.66 1.42e-34 Menarche (age at onset); CESC cis rs1008375 1.000 rs28693609 chr4:17645233 C/T cg15017067 chr4:17643749 FAM184B 0.37 5.23 0.31 3.39e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs977987 0.843 rs12928036 chr16:75483132 G/A cg03315344 chr16:75512273 CHST6 0.43 6.26 0.36 1.5e-9 Dupuytren's disease; CESC cis rs806215 0.950 rs2073561 chr7:127227769 G/C cg25922125 chr7:127225783 GCC1 -0.44 -5.05 -0.3 8.14e-7 Type 2 diabetes; CESC cis rs2730245 1.000 rs2657345 chr7:158744169 T/C cg24397884 chr7:158709396 WDR60 -0.88 -13.41 -0.64 1.25e-31 Height; CESC cis rs2243480 1.000 rs1499613 chr7:65730860 G/A cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC cis rs2108622 0.727 rs7251296 chr19:15983736 A/G cg13772218 chr19:15982569 NA 0.28 5.68 0.33 3.62e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC trans rs1728785 0.901 rs11075687 chr16:68655894 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.71 8.19 0.45 1.15e-14 Ulcerative colitis; CESC cis rs7940866 0.874 rs10791113 chr11:130873165 A/G cg12179176 chr11:130786555 SNX19 0.69 9.96 0.52 4.82e-20 Schizophrenia; CESC cis rs2439831 0.867 rs2927072 chr15:43922398 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.81 8.35 0.46 3.84e-15 Lung cancer in ever smokers; CESC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg14829155 chr15:31115871 NA -0.75 -10.54 -0.54 6.55e-22 Huntington's disease progression; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg22146484 chr8:57123862 CHCHD7;PLAG1 0.48 6.07 0.35 4.39e-9 Obesity-related traits; CESC cis rs6582630 0.519 rs4436613 chr12:38293653 T/C cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.23e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs7274811 0.723 rs6120329 chr20:32210238 T/G cg21523528 chr20:32077966 CBFA2T2 0.64 7.35 0.41 2.42e-12 Height; CESC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs950169 1.000 rs12903820 chr15:84723820 A/G cg17507749 chr15:85114479 UBE2QP1 0.63 6.93 0.39 3.26e-11 Schizophrenia; CESC cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.48 6.2 0.36 2.21e-9 Colorectal cancer; CESC cis rs13385 0.769 rs28573694 chr5:139609951 T/G cg26211634 chr5:139558579 C5orf32 0.47 5.19 0.3 4.23e-7 Atrial fibrillation; CESC cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg11764359 chr7:65958608 NA -0.82 -9.26 -0.49 7.38e-18 Aortic root size; CESC cis rs2228479 0.557 rs62056064 chr16:89903843 G/A cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs711830 0.587 rs10188827 chr2:177007664 C/T cg13092806 chr2:177043255 NA 0.57 6.43 0.37 5.76e-10 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CESC cis rs4925386 1.000 rs6089351 chr20:60916153 G/A cg22633769 chr20:60982531 CABLES2 -0.43 -5.09 -0.3 6.95e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.95 14.1 0.65 4.6e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs611744 0.573 rs629996 chr8:109255206 C/T cg21045802 chr8:109455806 TTC35 0.56 7.02 0.4 1.89e-11 Dupuytren's disease; CESC cis rs7084402 0.967 rs1649038 chr10:60330439 G/A cg07615347 chr10:60278583 BICC1 0.59 9.15 0.49 1.57e-17 Refractive error; CESC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg24060327 chr5:131705240 SLC22A5 0.76 10.74 0.55 1.43e-22 Breast cancer; CESC trans rs7618501 1.000 rs6785549 chr3:49736565 G/A cg21659725 chr3:3221576 CRBN -0.82 -13.41 -0.64 1.16e-31 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg24818145 chr4:99064322 C4orf37 0.38 5.05 0.3 8.39e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11638815 0.954 rs783544 chr15:83240293 A/C cg25333056 chr10:135107159 TUBGCP2 0.48 6.05 0.35 4.97e-9 Lipoprotein-associated phospholipase A2 activity change in response to statin therapy; CESC cis rs3733585 0.624 rs7376154 chr4:9952587 C/A cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6060717 0.536 rs6060699 chr20:34523833 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -7.76 -0.43 1.86e-13 Hip circumference adjusted for BMI; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08977639 chr16:1047820 NA -0.42 -6.31 -0.36 1.19e-9 Gambling; CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg12419862 chr22:24373484 LOC391322 -0.91 -14.19 -0.66 2.24e-34 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7647973 1.000 rs10865956 chr3:49581559 C/A cg07636037 chr3:49044803 WDR6 0.7 10.18 0.53 9.15e-21 Menarche (age at onset); CESC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg22823121 chr1:150693482 HORMAD1 0.4 5.64 0.33 4.46e-8 Melanoma; CESC cis rs1707322 0.721 rs7520123 chr1:46235219 C/G cg05343316 chr1:45956843 TESK2 0.49 6.27 0.36 1.47e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6831352 0.959 rs1139490 chr4:100045141 C/T cg13256891 chr4:100009986 ADH5 0.61 7.26 0.41 4.35e-12 Alcohol dependence; CESC cis rs1538970 0.924 rs4660858 chr1:45936351 G/A cg05343316 chr1:45956843 TESK2 0.9 12.33 0.6 6.6e-28 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15645344 chr4:165109574 MARCH1 -0.54 -6.21 -0.36 2.05e-9 Gut microbiome composition (summer); CESC trans rs66573146 1.000 rs6812771 chr4:6964048 G/A cg07817883 chr1:32538562 TMEM39B 1.51 9.21 0.49 1.06e-17 Granulocyte percentage of myeloid white cells; CESC cis rs1707322 1.000 rs4454479 chr1:46423555 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22511293 chr12:109915400 KCTD10;UBE3B 0.58 6.42 0.37 6.34e-10 Gut microbiome composition (summer); CESC cis rs79976124 0.719 rs34488909 chr6:66637850 T/C cg07460842 chr6:66804631 NA 0.69 8.03 0.44 3.13e-14 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00677986 chr12:80084523 PAWR 0.65 7.91 0.44 7.12e-14 Gut microbiome composition (summer); CESC cis rs7727544 0.735 rs274566 chr5:131715011 A/G cg24060327 chr5:131705240 SLC22A5 0.69 9.24 0.49 8.12e-18 Blood metabolite levels; CESC cis rs7772486 0.902 rs1331643 chr6:146398873 T/A cg23711669 chr6:146136114 FBXO30 0.74 10.93 0.56 3.43e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs2282802 0.685 rs2116790 chr5:139654115 G/A cg26211634 chr5:139558579 C5orf32 0.52 7.49 0.42 1.01e-12 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg05340658 chr4:99064831 C4orf37 0.81 12.59 0.61 8.13e-29 Colonoscopy-negative controls vs population controls; CESC cis rs4642101 0.855 rs9836128 chr3:12845426 G/C cg05775895 chr3:12838266 CAND2 0.39 5.78 0.33 2.1e-8 QRS complex (12-leadsum); CESC cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg20307385 chr11:47447363 PSMC3 -0.62 -7.41 -0.41 1.72e-12 Subjective well-being; CESC cis rs7917772 0.604 rs10883756 chr10:104400112 T/C cg04362960 chr10:104952993 NT5C2 0.39 5.04 0.3 8.43e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -8.17 -0.45 1.31e-14 Developmental language disorder (linguistic errors); CESC cis rs10905065 0.965 rs2797488 chr10:5784509 C/T cg11519256 chr10:5708881 ASB13 0.42 5.58 0.32 6.03e-8 Menopause (age at onset); CESC cis rs9393777 0.920 rs35869525 chr6:26946687 C/T cg21479132 chr6:26055353 NA 0.81 5.92 0.34 9.95e-9 Intelligence (multi-trait analysis); CESC trans rs8073060 0.586 rs72829923 chr17:34045089 T/A cg19694781 chr19:47549865 TMEM160 0.72 6.47 0.37 4.78e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7927592 0.956 rs11228278 chr11:68308530 G/A cg20283391 chr11:68216788 NA -0.49 -6.25 -0.36 1.61e-9 Total body bone mineral density; CESC cis rs1348850 0.632 rs1358328 chr2:178517532 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 7.37 0.41 2.12e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs7116495 0.609 rs3750907 chr11:71822560 T/C cg07596299 chr11:71824057 C11orf51 0.82 5.06 0.3 8e-7 Severe influenza A (H1N1) infection; CESC trans rs61931739 0.500 rs7295779 chr12:34460652 T/C cg26384229 chr12:38710491 ALG10B 0.56 7.89 0.44 7.84e-14 Morning vs. evening chronotype; CESC cis rs889398 0.651 rs1566455 chr16:69900164 G/T cg09409435 chr16:70099608 PDXDC2 0.4 5.11 0.3 6.15e-7 Body mass index; CESC cis rs1559088 0.739 rs9304845 chr19:33592794 A/G cg17764715 chr19:33622953 WDR88 0.48 6.27 0.36 1.49e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9818758 0.607 rs9880088 chr3:49178990 G/A cg00383909 chr3:49044727 WDR6 0.85 6.44 0.37 5.54e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs2404602 0.591 rs11635162 chr15:76951105 C/T cg00316803 chr15:76480434 C15orf27 0.43 5.84 0.34 1.56e-8 Blood metabolite levels; CESC trans rs7307889 0.793 rs55712234 chr12:6006618 G/T cg18407955 chr7:158110685 PTPRN2 -0.74 -6.29 -0.36 1.29e-9 Obesity-related traits; CESC cis rs1707322 0.721 rs11211181 chr1:46236800 C/T cg06784218 chr1:46089804 CCDC17 0.39 7.05 0.4 1.55e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2425143 1.000 rs8115150 chr20:34397189 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.88 0.34 1.24e-8 Blood protein levels; CESC cis rs11098499 0.954 rs10034623 chr4:120397829 G/A cg24375607 chr4:120327624 NA 0.45 5.68 0.33 3.51e-8 Corneal astigmatism; CESC trans rs2733310 0.948 rs2703594 chr15:57488790 C/G cg08773106 chr17:30055218 NA 0.39 6.01 0.35 6.15e-9 Mean platelet volume; CESC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.25e-30 Prudent dietary pattern; CESC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg19592336 chr6:28129416 ZNF389 0.47 6.96 0.39 2.68e-11 Cardiac Troponin-T levels; CESC cis rs1348850 0.598 rs12616259 chr2:178503803 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 7.56 0.42 6.75e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7216064 0.589 rs8072723 chr17:66056970 T/A cg07042672 chr17:66097459 LOC651250 0.67 8.94 0.48 7.02e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg19592336 chr6:28129416 ZNF389 0.64 8.79 0.47 1.97e-16 Depression; CESC cis rs6493487 0.512 rs2899459 chr15:51130369 A/T cg02338191 chr15:51200825 AP4E1 0.5 5.12 0.3 5.93e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg11987759 chr7:65425863 GUSB -0.46 -6.24 -0.36 1.69e-9 Aortic root size; CESC cis rs7551222 0.752 rs4245736 chr1:204486205 G/C cg20240347 chr1:204465584 NA -0.28 -5.61 -0.33 5.15e-8 Schizophrenia; CESC cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.33 0.54 2.98e-21 Monocyte percentage of white cells; CESC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.48 6.9 0.39 3.72e-11 Menopause (age at onset); CESC cis rs10979 0.557 rs9376768 chr6:143909492 C/T cg25407410 chr6:143891975 LOC285740 -0.49 -6.55 -0.37 2.98e-10 Hypospadias; CESC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg11764359 chr7:65958608 NA 0.7 8.96 0.48 5.88e-17 Calcium levels; CESC cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11088226 0.681 rs2833895 chr21:33929802 G/A cg09050820 chr6:167586206 TCP10L2 0.87 8.52 0.46 1.23e-15 Gastritis; CESC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg04673462 chr1:38461896 NA 0.4 6.12 0.35 3.3e-9 Coronary artery disease; CESC cis rs6120849 1.000 rs6120849 chr20:33730387 C/T cg06115741 chr20:33292138 TP53INP2 0.5 5.16 0.3 4.95e-7 Protein C levels; CESC cis rs9398803 0.723 rs853972 chr6:127068293 C/G cg19875578 chr6:126661172 C6orf173 -0.42 -5.85 -0.34 1.41e-8 Male-pattern baldness; CESC cis rs721399 0.513 rs35354956 chr8:18241319 T/C cg18736775 chr8:18248649 NAT2 -0.57 -5.93 -0.34 9.51e-9 Blood metabolite levels; CESC cis rs4243830 0.850 rs6679649 chr1:6606608 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 1.03 10.76 0.55 1.18e-22 Body mass index; CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 7.52 0.42 8.72e-13 Bipolar disorder; CESC cis rs4588572 0.643 rs10942857 chr5:77760241 A/G cg11547950 chr5:77652471 NA -0.44 -5.48 -0.32 9.67e-8 Triglycerides; CESC cis rs798554 0.616 rs1636251 chr7:2884720 T/C cg04166393 chr7:2884313 GNA12 0.42 5.58 0.32 6.06e-8 Height; CESC cis rs17826219 0.706 rs28469200 chr17:29133572 T/A cg19761014 chr17:28927070 LRRC37B2 0.73 6.11 0.35 3.45e-9 Body mass index; CESC cis rs3767633 0.925 rs2499855 chr1:161929761 C/T cg09175582 chr1:161736000 ATF6 0.96 7.8 0.43 1.44e-13 IgG glycosylation; CESC cis rs9581857 0.685 rs9319368 chr13:28042275 T/G cg01674679 chr13:27998804 GTF3A -0.69 -5.52 -0.32 8.1e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg05025164 chr4:1340916 KIAA1530 0.44 5.75 0.33 2.4e-8 Longevity; CESC cis rs9457247 0.646 rs239934 chr6:167412048 G/A cg23791538 chr6:167370224 RNASET2 -0.6 -8.71 -0.47 3.24e-16 Crohn's disease; CESC cis rs7224314 1.000 rs8066725 chr17:65387326 G/A cg01507342 chr17:65387096 PITPNC1 -0.48 -5.67 -0.33 3.82e-8 Diisocyanate-induced asthma; CESC cis rs9549367 0.713 rs1323315 chr13:113859658 T/C cg00898013 chr13:113819073 PROZ 0.45 6.84 0.39 5.47e-11 Platelet distribution width; CESC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg16743903 chr16:89593216 SPG7 0.4 5.23 0.31 3.44e-7 Multiple myeloma (IgH translocation); CESC cis rs765787 0.530 rs2899381 chr15:45529630 C/T cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs12118280 0.612 rs591141 chr1:108694894 A/G cg11967332 chr1:108735228 SLC25A24 0.59 6.73 0.38 1.04e-10 Myeloid white cell count; CESC trans rs931812 0.825 rs13271753 chr8:101895491 T/C cg20993868 chr7:22813445 NA 0.55 7.69 0.43 2.83e-13 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC cis rs2288073 0.562 rs112892911 chr2:24590800 G/A cg20701182 chr2:24300061 SF3B14 0.62 6.65 0.38 1.62e-10 Venous thromboembolism (SNP x SNP interaction); CESC cis rs34779708 0.931 rs4934704 chr10:35332164 C/T cg03585969 chr10:35415529 CREM 0.77 10.25 0.53 5.44e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs854765 0.547 rs7224047 chr17:17932931 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.66 0.47 4.83e-16 Total body bone mineral density; CESC cis rs1691799 0.899 rs903587 chr12:66746061 C/A cg16791601 chr12:66731901 HELB -0.79 -14.55 -0.67 1.18e-35 White blood cell count (basophil); CESC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.43 0.54 1.5e-21 Prudent dietary pattern; CESC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg12311346 chr5:56204834 C5orf35 -0.66 -8.11 -0.45 1.85e-14 Initial pursuit acceleration; CESC cis rs68170813 0.559 rs12537733 chr7:106965447 A/T cg02696742 chr7:106810147 HBP1 -0.56 -5.36 -0.31 1.79e-7 Coronary artery disease; CESC cis rs6987853 0.787 rs2923437 chr8:42425399 A/C cg09913449 chr8:42400586 C8orf40 0.46 7.81 0.43 1.34e-13 Mean corpuscular hemoglobin concentration; CESC cis rs4635969 0.718 rs27068 chr5:1347239 C/T cg06550200 chr5:1325588 CLPTM1L -0.71 -8.13 -0.45 1.62e-14 Testicular germ cell tumor;Testicular germ cell cancer; CESC cis rs8002861 0.905 rs12428350 chr13:44446161 G/A cg14210620 chr13:44453864 C13orf31;CCDC122 -0.45 -5.63 -0.33 4.47e-8 Leprosy; CESC cis rs524281 0.861 rs1862005 chr11:65863402 T/C cg14036092 chr11:66035641 RAB1B -0.62 -6.29 -0.36 1.27e-9 Electroencephalogram traits; CESC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs796364 0.760 rs56225698 chr2:200910653 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC cis rs12079745 0.793 rs10919079 chr1:169133805 A/G cg09363564 chr1:169337483 NME7;BLZF1 -0.98 -5.99 -0.35 6.97e-9 QT interval; CESC cis rs826838 0.834 rs826874 chr12:39122599 C/A cg13010199 chr12:38710504 ALG10B -0.42 -5.83 -0.34 1.61e-8 Heart rate; CESC cis rs1595825 0.838 rs57437055 chr2:198782617 A/C cg10820045 chr2:198174542 NA 0.41 5.06 0.3 7.8e-7 Ulcerative colitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11285937 chr4:39979757 PDS5A -0.44 -6.19 -0.36 2.34e-9 Gambling; CESC cis rs1941023 0.584 rs10897057 chr11:60172273 A/T cg08716584 chr11:60157161 MS4A7 -0.55 -9.03 -0.48 3.7e-17 Congenital heart disease (maternal effect); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01034784 chr2:95831832 ZNF2 0.44 6.23 0.36 1.83e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.62 0.55 3.47e-22 Platelet count; CESC cis rs2108622 0.727 rs3093216 chr19:15987737 A/G cg13772218 chr19:15982569 NA 0.31 5.86 0.34 1.34e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg27301331 chr6:20401917 E2F3 -0.49 -6.29 -0.36 1.33e-9 Height; CESC cis rs11971779 0.638 rs77668044 chr7:139111085 T/A cg07862535 chr7:139043722 LUC7L2 0.53 5.03 0.3 9.18e-7 Diisocyanate-induced asthma; CESC cis rs2439831 0.850 rs28513374 chr15:44125495 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.43 0.42 1.45e-12 Lung cancer in ever smokers; CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg17178900 chr1:205818956 PM20D1 0.89 15.71 0.69 9.72e-40 Menarche (age at onset); CESC cis rs8020095 0.571 rs10148117 chr14:67426228 G/A cg19548862 chr14:67692701 FAM71D -0.48 -5.86 -0.34 1.4e-8 Depression (quantitative trait); CESC cis rs3087591 0.960 rs4795593 chr17:29613600 G/C cg24425628 chr17:29625626 OMG;NF1 -0.44 -5.46 -0.32 1.09e-7 Hip circumference; CESC cis rs61931739 0.500 rs11053207 chr12:34459827 A/G cg23762105 chr12:34175262 ALG10 -0.4 -5.22 -0.31 3.7e-7 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.2.1420302F chr2:62093097 NA -0.53 -6.34 -0.36 9.82e-10 Gut microbiome composition (summer); CESC cis rs727563 0.565 rs132774 chr22:42031953 C/G cg03806693 chr22:41940476 POLR3H -0.73 -8.59 -0.47 7.79e-16 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12446722 chr1:226374380 ACBD3 0.58 6.4 0.37 7.03e-10 Gut microbiome composition (summer); CESC cis rs4654899 1.000 rs6426659 chr1:21361302 G/A cg05370193 chr1:21551575 ECE1 0.39 5.85 0.34 1.47e-8 Superior frontal gyrus grey matter volume; CESC cis rs6028335 0.674 rs67379757 chr20:37671051 C/G cg16355469 chr20:37678765 NA 0.52 5.15 0.3 5.19e-7 Alcohol and nicotine co-dependence; CESC cis rs909002 0.819 rs2292989 chr1:32135773 A/G cg13919466 chr1:32135498 COL16A1 0.39 6.56 0.37 2.88e-10 Intelligence (multi-trait analysis); CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg07092213 chr7:1199455 ZFAND2A -0.45 -5.21 -0.3 3.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg13147721 chr7:65941812 NA 0.37 5.04 0.3 8.52e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25365034 chr2:23785230 KLHL29 0.47 6.14 0.35 2.96e-9 Fibrinogen levels; CESC cis rs11166927 0.548 rs2100803 chr8:140839371 A/C cg16909799 chr8:140841666 TRAPPC9 -0.65 -10.2 -0.53 8.15e-21 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs3015497 0.586 rs12587821 chr14:51092554 A/G cg09863266 chr14:51125203 SAV1 -0.32 -5.07 -0.3 7.62e-7 Mean platelet volume; CESC cis rs2732480 0.577 rs2732457 chr12:48758379 A/G cg04545296 chr12:48745243 ZNF641 -0.4 -6.66 -0.38 1.55e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7937682 0.961 rs552387 chr11:111490047 T/G cg09085632 chr11:111637200 PPP2R1B -0.92 -14.14 -0.66 3.34e-34 Primary sclerosing cholangitis; CESC cis rs8108034 0.666 rs40353 chr19:39879663 A/G cg02980416 chr19:40502895 ZNF546 0.57 5.31 0.31 2.34e-7 Lung adenocarcinoma; CESC cis rs2115630 1.000 rs6496441 chr15:85363348 A/G cg12501888 chr15:85177176 SCAND2 -0.39 -5.1 -0.3 6.42e-7 P wave terminal force; CESC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg17376030 chr22:41985996 PMM1 0.7 7.6 0.42 5.18e-13 Vitiligo; CESC cis rs7927771 0.832 rs10838697 chr11:47384484 T/A cg05585544 chr11:47624801 NA -0.51 -7.36 -0.41 2.28e-12 Subjective well-being; CESC cis rs472109 0.967 rs173396 chr11:9759918 G/A cg03108697 chr11:9732066 SWAP70 -0.37 -5.54 -0.32 7.15e-8 Coronary artery disease; CESC cis rs3740713 1.000 rs73440615 chr11:18467283 T/C cg23797887 chr11:18477753 LDHAL6A -0.53 -5.26 -0.31 2.98e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7116495 0.786 rs610004 chr11:71797939 C/T cg10381502 chr11:71823885 C11orf51 -0.66 -5.4 -0.31 1.51e-7 Severe influenza A (H1N1) infection; CESC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg18891404 chr1:37940488 ZC3H12A -0.57 -6.69 -0.38 1.33e-10 Gut microbiota (bacterial taxa); CESC cis rs8014204 0.804 rs2287403 chr14:75259140 C/T cg08847533 chr14:75593920 NEK9 0.47 5.9 0.34 1.08e-8 Caffeine consumption; CESC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg23708337 chr7:1209742 NA 0.55 5.42 0.32 1.33e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs3780486 0.846 rs10971419 chr9:33124161 T/C cg04842962 chr6:43655489 MRPS18A 1.01 19.48 0.77 4.55e-53 IgG glycosylation; CESC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg02564969 chr6:151773285 C6orf211;RMND1 0.64 8.72 0.47 3.02e-16 Menarche (age at onset); CESC cis rs7532866 0.885 rs7520137 chr1:26731035 T/G cg17456097 chr1:26900765 RPS6KA1 -0.47 -6.04 -0.35 5.23e-9 Height; CESC cis rs761746 0.739 rs5753714 chr22:31990930 G/T cg25791279 chr22:32026902 PISD -0.66 -7.58 -0.42 5.96e-13 Intelligence; CESC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg18876405 chr7:65276391 NA 0.52 6.87 0.39 4.58e-11 Aortic root size; CESC cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg20891283 chr12:69753455 YEATS4 0.76 11.37 0.57 1.16e-24 Blood protein levels; CESC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg20203395 chr5:56204925 C5orf35 0.48 5.64 0.33 4.44e-8 Initial pursuit acceleration; CESC cis rs9611519 0.894 rs9623320 chr22:41478482 G/A cg03806693 chr22:41940476 POLR3H -0.58 -6.03 -0.35 5.61e-9 Neuroticism; CESC cis rs561341 0.941 rs8066558 chr17:30272879 G/T cg12193833 chr17:30244370 NA -0.61 -6.2 -0.36 2.19e-9 Hip circumference adjusted for BMI; CESC cis rs8063761 1.000 rs8063761 chr16:90027626 A/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 0.57 7.23 0.41 5.26e-12 Squamous cell carcinoma; CESC cis rs6570726 0.902 rs396681 chr6:145853603 T/C cg05347473 chr6:146136440 FBXO30 0.47 6.19 0.36 2.25e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs2404602 0.692 rs35498563 chr15:76958868 C/T cg22467129 chr15:76604101 ETFA -0.35 -5.14 -0.3 5.22e-7 Blood metabolite levels; CESC cis rs60843830 1.000 rs60484953 chr2:221560 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.78 9.77 0.51 1.94e-19 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1499972 0.938 rs843852 chr3:117721428 A/G cg07612923 chr3:117604196 NA -0.78 -5.78 -0.33 2.13e-8 Schizophrenia; CESC trans rs9951602 0.512 rs9946123 chr18:76654557 A/G cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs6775745 0.654 rs12695570 chr3:131782365 C/T cg12213930 chr3:131751605 CPNE4 0.48 5.46 0.32 1.08e-7 Neutrophil count; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg00465686 chr8:66701377 PDE7A 0.38 6.36 0.36 8.89e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3733585 0.699 rs6852441 chr4:9973744 C/T cg00071950 chr4:10020882 SLC2A9 -0.69 -11.21 -0.57 3.85e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6570726 0.935 rs377130 chr6:145836632 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg24733560 chr20:60626293 TAF4 0.45 6.44 0.37 5.45e-10 Body mass index; CESC cis rs7772486 0.686 rs857882 chr6:145969716 T/G cg23711669 chr6:146136114 FBXO30 -0.98 -15.19 -0.68 6.34e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs2658782 0.547 rs3020064 chr11:93060851 A/G cg15737290 chr11:93063684 CCDC67 0.53 7.2 0.4 6.34e-12 Pulmonary function decline; CESC cis rs7599312 0.534 rs2128321 chr2:213405276 G/T cg20637307 chr2:213403960 ERBB4 0.56 9.03 0.49 3.55e-17 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg23711669 chr6:146136114 FBXO30 0.97 15.02 0.68 2.59e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs7255436 0.965 rs7254882 chr19:8453822 A/G cg10174797 chr19:8464628 RAB11B 0.38 5.39 0.31 1.55e-7 HDL cholesterol; CESC cis rs826838 1.000 rs7315028 chr12:38710523 G/A cg13010199 chr12:38710504 ALG10B 0.61 8.88 0.48 1.03e-16 Heart rate; CESC cis rs761746 0.960 rs14034 chr22:32015406 T/C cg25791279 chr22:32026902 PISD 0.56 6.55 0.37 2.93e-10 Intelligence; CESC cis rs4595586 0.545 rs58154430 chr12:39386649 C/T cg26384229 chr12:38710491 ALG10B 0.62 8.69 0.47 3.89e-16 Morning vs. evening chronotype; CESC cis rs4253772 0.591 rs73886791 chr22:46687212 A/G cg18190219 chr22:46762943 CELSR1 -0.43 -5.4 -0.31 1.46e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg24308560 chr3:49941425 MST1R -0.53 -7.51 -0.42 9.01e-13 Body mass index; CESC cis rs1881797 0.872 rs12404733 chr1:247690417 A/C cg21399703 chr1:247681439 NA 0.53 7.49 0.42 1.05e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs11098499 0.863 rs28718422 chr4:120466304 C/A cg09307838 chr4:120376055 NA 0.91 12.73 0.62 2.82e-29 Corneal astigmatism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21159473 chr9:15510228 PSIP1 -0.48 -6.57 -0.37 2.71e-10 Ulcerative colitis; CESC cis rs10089 1.000 rs72794392 chr5:127490061 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 9.58 0.51 7.24e-19 Ileal carcinoids; CESC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg15445000 chr17:37608096 MED1 0.42 6.9 0.39 3.93e-11 Glomerular filtration rate (creatinine); CESC cis rs17376456 0.825 rs6865441 chr5:93284746 G/A cg21475434 chr5:93447410 FAM172A 0.79 6.2 0.36 2.11e-9 Diabetic retinopathy; CESC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg13607699 chr17:42295918 UBTF -0.57 -7.41 -0.41 1.71e-12 Total body bone mineral density; CESC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Depression; CESC cis rs9303280 0.901 rs9303277 chr17:37976469 C/T cg20243544 chr17:37824526 PNMT 0.47 6.45 0.37 5.3e-10 Self-reported allergy; CESC cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg05340658 chr4:99064831 C4orf37 0.79 12.42 0.61 3.26e-28 Colonoscopy-negative controls vs population controls; CESC cis rs8070624 0.574 rs9914127 chr17:17875836 A/T cg16928487 chr17:17741425 SREBF1 -0.54 -8.64 -0.47 5.35e-16 Total body bone mineral density; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg10069470 chr5:102594905 C5orf30 -0.47 -6.11 -0.35 3.56e-9 Gut microbiota (bacterial taxa); CESC cis rs1538970 0.924 rs2088100 chr1:45877575 C/T cg05343316 chr1:45956843 TESK2 0.85 11.89 0.59 1.99e-26 Platelet count; CESC cis rs7726839 0.561 rs4957048 chr5:583442 G/A cg16447950 chr5:562315 NA -0.55 -6.19 -0.36 2.29e-9 Obesity-related traits; CESC cis rs7084402 1.000 rs1863664 chr10:60266839 A/G cg07615347 chr10:60278583 BICC1 -0.58 -8.92 -0.48 8.11e-17 Refractive error; CESC cis rs36051895 0.626 rs10815149 chr9:5063701 T/C cg02405213 chr9:5042618 JAK2 -0.45 -5.69 -0.33 3.38e-8 Pediatric autoimmune diseases; CESC cis rs9584850 0.834 rs9584854 chr13:99118590 C/T cg22223119 chr13:99095684 FARP1 -0.35 -5.05 -0.3 8.13e-7 Neuroticism; CESC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg10792982 chr14:105748885 BRF1 0.42 5.24 0.31 3.21e-7 Mean platelet volume;Platelet distribution width; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.1.1697717F chr1:59122002 NA 0.46 6.12 0.35 3.32e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs950027 0.620 rs1719246 chr15:45625479 T/A cg21132104 chr15:45694354 SPATA5L1 0.68 8.74 0.47 2.67e-16 Response to fenofibrate (adiponectin levels); CESC cis rs892961 0.867 rs312909 chr17:75413954 T/C cg05865280 chr17:75406074 SEPT9 0.63 12.81 0.62 1.5e-29 Airflow obstruction; CESC cis rs863345 0.526 rs10908669 chr1:158501938 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.76 -0.38 8.6e-11 Pneumococcal bacteremia; CESC cis rs28647808 0.881 rs4246171 chr9:136264731 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17860962 chr6:44214684 HSP90AB1 -0.56 -6.52 -0.37 3.64e-10 Gut microbiome composition (summer); CESC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg27121462 chr16:89883253 FANCA 0.78 11.15 0.57 6.29e-24 Vitiligo; CESC cis rs2439831 0.681 rs540031 chr15:43608855 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.9 11.15 0.56 6.51e-24 Lung cancer in ever smokers; CESC cis rs10463316 0.780 rs6894899 chr5:150775913 C/T cg03212797 chr5:150827313 SLC36A1 -0.44 -5.7 -0.33 3.19e-8 Metabolite levels (Pyroglutamine); CESC cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg08213375 chr14:104286397 PPP1R13B 0.32 5.32 0.31 2.21e-7 Reticulocyte count; CESC cis rs62103177 0.525 rs62101233 chr18:77724288 C/T cg12964065 chr18:77638022 KCNG2 0.43 5.04 0.3 8.46e-7 Opioid sensitivity; CESC cis rs8077577 0.708 rs4450455 chr17:18140447 A/G cg16794390 chr17:18148240 FLII -0.43 -6.28 -0.36 1.36e-9 Obesity-related traits; CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg05332525 chr7:65337924 VKORC1L1 0.47 6.01 0.35 6.14e-9 Calcium levels; CESC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg11663144 chr21:46675770 NA -0.62 -9.71 -0.51 2.89e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9399135 0.967 rs17638970 chr6:135320063 A/G cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC trans rs2018683 0.711 rs2158788 chr7:28971958 G/A cg19402173 chr7:128379420 CALU -0.54 -7.01 -0.4 1.93e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg11301795 chr4:187892539 NA -0.75 -12.37 -0.61 4.63e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg06873352 chr17:61820015 STRADA 0.73 12.98 0.62 3.9e-30 Prudent dietary pattern; CESC cis rs6736093 0.966 rs71414616 chr2:112696684 T/C cg12686935 chr2:112915763 FBLN7 -0.43 -5.56 -0.32 6.75e-8 Coronary artery disease; CESC cis rs2742417 0.603 rs2742449 chr3:45764544 T/C cg04837898 chr3:45731254 SACM1L -0.47 -6.17 -0.35 2.54e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg15145296 chr3:125709740 NA -0.53 -5.52 -0.32 8.24e-8 Blood pressure (smoking interaction); CESC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.53 -0.37 3.33e-10 Bipolar disorder; CESC cis rs4722166 0.630 rs1829927 chr7:22779918 G/A cg05265849 chr7:22767390 IL6 0.57 7.11 0.4 1.06e-11 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17327406 chr4:6303265 WFS1 0.51 6.78 0.38 7.64e-11 Fibrinogen levels; CESC cis rs2836633 0.895 rs62217513 chr21:40024416 A/T cg12884169 chr21:40033163 ERG 0.38 5.87 0.34 1.33e-8 Coronary artery disease; CESC cis rs7618501 0.966 rs2246832 chr3:49881134 A/T cg24308560 chr3:49941425 MST1R -0.55 -7.5 -0.42 9.72e-13 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.25 -0.36 1.65e-9 Depression; CESC cis rs10129255 0.957 rs8022165 chr14:107189919 C/G cg23076370 chr14:107095027 NA -0.46 -5.95 -0.34 8.57e-9 Kawasaki disease; CESC cis rs1790761 0.505 rs7106423 chr11:67314144 A/G cg24690094 chr11:67383802 NA -0.32 -5.39 -0.31 1.52e-7 Mean corpuscular volume; CESC cis rs6693567 0.565 rs8006 chr1:150280801 G/C cg09579323 chr1:150459698 TARS2 -0.46 -5.97 -0.34 7.61e-9 Migraine; CESC cis rs9300255 0.596 rs10734900 chr12:123743445 G/A cg19016782 chr12:123741754 C12orf65 -0.38 -5.73 -0.33 2.74e-8 Neutrophil percentage of white cells; CESC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg07701084 chr6:150067640 NUP43 0.46 6.42 0.37 6.39e-10 Lung cancer; CESC cis rs9916302 0.706 rs9899069 chr17:37540772 A/G cg07936489 chr17:37558343 FBXL20 0.9 9.82 0.52 1.27e-19 Glomerular filtration rate (creatinine); CESC cis rs643506 0.817 rs1940392 chr11:111776846 G/A cg09085632 chr11:111637200 PPP2R1B 0.41 5.36 0.31 1.79e-7 Breast cancer; CESC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg24531977 chr5:56204891 C5orf35 -0.88 -11.18 -0.57 4.92e-24 Initial pursuit acceleration; CESC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg03388025 chr16:89894329 SPIRE2 0.38 7.25 0.41 4.6e-12 Vitiligo; CESC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg26338869 chr17:61819248 STRADA -0.7 -9.34 -0.5 4.19e-18 Prudent dietary pattern; CESC cis rs9902453 0.868 rs9902340 chr17:28476458 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -8.44 -0.46 2.07e-15 Coffee consumption (cups per day); CESC cis rs12586317 0.586 rs74243591 chr14:35520917 C/T cg05294307 chr14:35346193 BAZ1A -0.57 -5.82 -0.34 1.71e-8 Psoriasis; CESC cis rs1005224 0.963 rs11626062 chr14:76136329 T/C cg25116370 chr14:76127843 TTLL5;C14orf1 -0.41 -5.5 -0.32 8.98e-8 Large artery stroke; CESC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg10691866 chr7:65817282 TPST1 -0.34 -5.46 -0.32 1.12e-7 Aortic root size; CESC cis rs7666738 0.830 rs7659593 chr4:98934823 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.98 10.48 0.54 9.63e-22 Platelet count; CESC cis rs1008375 0.931 rs6449328 chr4:17700474 C/T cg16339924 chr4:17578868 LAP3 0.62 7.64 0.42 4.03e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2243480 1.000 rs35058610 chr7:65390925 G/A cg25894440 chr7:65020034 NA -0.59 -5.07 -0.3 7.57e-7 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17340796 chr11:85339599 TMEM126B;DLG2 0.61 7.04 0.4 1.6e-11 Gut microbiome composition (summer); CESC cis rs1483890 0.642 rs9825849 chr3:69404575 C/T cg22125112 chr3:69402811 FRMD4B 0.39 5.32 0.31 2.22e-7 Resting heart rate; CESC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg04944784 chr2:26401820 FAM59B 0.96 10.5 0.54 8.76e-22 Gut microbiome composition (summer); CESC cis rs2637266 0.654 rs846576 chr10:78500388 T/A cg18941641 chr10:78392320 NA 0.39 7.43 0.42 1.54e-12 Pulmonary function; CESC cis rs1348850 0.831 rs1345139 chr2:178449791 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.27 0.41 4.13e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg26335602 chr6:28129616 ZNF389 0.52 6.86 0.39 4.89e-11 Depression; CESC cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg05283184 chr6:79620031 NA -0.43 -6.5 -0.37 3.91e-10 Intelligence (multi-trait analysis); CESC cis rs2932538 0.922 rs12137107 chr1:113127437 A/G cg22162597 chr1:113214053 CAPZA1 0.54 6.9 0.39 3.82e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs5758511 0.680 rs5758698 chr22:42684818 C/T cg00645731 chr22:42541494 CYP2D7P1 0.59 8.95 0.48 6.42e-17 Birth weight; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20831041 chr11:464554 PTDSS2 0.45 6.01 0.35 6.27e-9 Fibrinogen levels; CESC cis rs1008375 1.000 rs4698649 chr4:17692782 A/G cg16339924 chr4:17578868 LAP3 0.6 7.44 0.42 1.45e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg02569458 chr12:86230093 RASSF9 0.48 7.44 0.42 1.4e-12 Major depressive disorder; CESC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs4481887 0.927 rs4453080 chr1:248474671 T/C cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg12463550 chr7:65579703 CRCP -0.52 -6.65 -0.38 1.65e-10 Aortic root size; CESC cis rs9287719 0.967 rs7582775 chr2:10738449 C/T cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs10918270 1.000 rs10800151 chr1:161914283 A/G cg19735514 chr1:161762739 ATF6 -0.37 -5.41 -0.32 1.41e-7 Parkinson's disease (age of onset); CESC cis rs684232 0.666 rs461521 chr17:622497 G/T cg15660573 chr17:549704 VPS53 -0.66 -9.12 -0.49 1.92e-17 Prostate cancer; CESC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg07414643 chr4:187882934 NA 0.49 7.04 0.4 1.65e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs709400 0.663 rs11628969 chr14:103940911 G/A cg12935359 chr14:103987150 CKB -0.51 -7.44 -0.42 1.39e-12 Body mass index; CESC cis rs3857067 0.806 rs34396894 chr4:95097600 T/G cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.07 -0.49 2.67e-17 QT interval; CESC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.09 -0.49 2.35e-17 Alzheimer's disease; CESC cis rs2050392 0.928 rs6481677 chr10:30701816 A/G cg25182066 chr10:30743637 MAP3K8 -0.38 -5.16 -0.3 4.81e-7 Inflammatory bowel disease; CESC trans rs2235573 0.625 rs713991 chr22:38426043 A/G cg19894588 chr14:64061835 NA 0.47 6.15 0.35 2.81e-9 Glioblastoma;Glioma; CESC cis rs760805 1.000 rs7517302 chr1:25254317 C/T cg22509179 chr1:25234806 RUNX3 -0.6 -8.45 -0.46 1.98e-15 Allergic disease (asthma, hay fever or eczema); CESC cis rs7940866 0.740 rs2162060 chr11:130830763 A/G cg12179176 chr11:130786555 SNX19 0.62 9.14 0.49 1.64e-17 Schizophrenia; CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -5.13 -0.3 5.56e-7 Bipolar disorder; CESC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 8.63 0.47 5.71e-16 Personality dimensions; CESC cis rs3733585 0.673 rs10018204 chr4:9964570 C/T cg11266682 chr4:10021025 SLC2A9 -0.59 -10.94 -0.56 3.01e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10791323 0.572 rs4353292 chr11:133742656 A/G cg15485101 chr11:133734466 NA 0.33 5.59 0.32 5.57e-8 Childhood ear infection; CESC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg21285383 chr16:89894308 SPIRE2 0.32 5.7 0.33 3.24e-8 Vitiligo; CESC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg03609598 chr5:56110824 MAP3K1 -0.5 -5.39 -0.31 1.52e-7 Initial pursuit acceleration; CESC cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.35 0.31 1.94e-7 Tonsillectomy; CESC cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 6.74 0.38 9.97e-11 Colorectal cancer; CESC cis rs501120 0.925 rs559469 chr10:44752118 C/T cg09554077 chr10:44749378 NA -0.56 -7.56 -0.42 6.45e-13 Coronary artery disease;Coronary heart disease; CESC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg19626725 chr5:178986131 RUFY1 -0.41 -6.69 -0.38 1.35e-10 Lung cancer; CESC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.28 0.53 4.4e-21 Prudent dietary pattern; CESC cis rs12477438 0.501 rs11685756 chr2:99766215 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.48 0.69 6.26e-39 Chronic sinus infection; CESC cis rs11122272 0.735 rs973253 chr1:231520874 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs11792861 0.890 rs57387569 chr9:111920392 T/C cg13535736 chr9:111863775 C9orf5 -0.53 -6.82 -0.39 6.2e-11 Menarche (age at onset); CESC cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg19077165 chr18:44547161 KATNAL2 -0.61 -9.19 -0.49 1.2e-17 Personality dimensions; CESC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg14159672 chr1:205819179 PM20D1 0.81 12.95 0.62 4.67e-30 Menarche (age at onset); CESC cis rs1865721 1.000 rs62089503 chr18:73177766 C/T cg26385618 chr18:73139727 C18orf62 -0.52 -7.51 -0.42 8.78e-13 Intelligence; CESC cis rs12711979 0.509 rs10205540 chr2:3827839 A/G cg17052675 chr2:3827356 NA -0.67 -11.25 -0.57 2.84e-24 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs11696501 0.688 rs6073851 chr20:44306978 C/T cg11783356 chr20:44313418 WFDC10B -0.31 -5.05 -0.3 8.38e-7 Brain structure; CESC cis rs854765 0.583 rs7207395 chr17:17819335 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.52 7.13 0.4 9.44e-12 Total body bone mineral density; CESC cis rs7621025 0.500 rs12629000 chr3:136643571 T/A cg15507776 chr3:136538369 TMEM22 0.77 9.21 0.49 1e-17 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs1018836 0.608 rs11997663 chr8:91474484 A/C cg16814680 chr8:91681699 NA -0.55 -7.5 -0.42 9.77e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9467711 0.606 rs9358936 chr6:26370657 A/G cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs17818399 0.926 rs13032670 chr2:46830794 C/T cg06386533 chr2:46925753 SOCS5 0.47 5.19 0.3 4.11e-7 Height; CESC trans rs13247936 0.574 rs12702800 chr7:8965291 A/G cg13381646 chr12:105379979 C12orf45 -0.48 -6.32 -0.36 1.09e-9 Schizophrenia; CESC cis rs6815814 0.950 rs5743580 chr4:38804405 C/T cg02016764 chr4:38805732 TLR1 -0.62 -7.23 -0.41 5.15e-12 Breast cancer; CESC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg04944784 chr2:26401820 FAM59B -0.66 -7.62 -0.42 4.62e-13 Gut microbiome composition (summer); CESC cis rs881375 0.967 rs2416806 chr9:123690292 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.08 0.3 7.23e-7 Rheumatoid arthritis; CESC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg18876405 chr7:65276391 NA 0.51 5.96 0.34 8.21e-9 Aortic root size; CESC cis rs11245387 0.633 rs2086945 chr10:126543993 C/T cg08799069 chr10:126477246 METTL10 0.43 5.63 0.33 4.71e-8 Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1); CESC cis rs9796 0.663 rs11853192 chr15:41368515 G/A cg20272979 chr15:41787780 ITPKA 0.37 5.62 0.33 4.95e-8 Menopause (age at onset); CESC cis rs1707322 0.721 rs12037803 chr1:46156492 A/G cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7647973 0.600 rs11920267 chr3:49275964 G/A cg02487422 chr3:49467188 NICN1 0.39 5.43 0.32 1.25e-7 Menarche (age at onset); CESC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs7202877 0.706 rs8054586 chr16:75410705 G/C cg04384234 chr16:75411784 CFDP1 -0.47 -5.73 -0.33 2.72e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs2243480 1.000 rs34529418 chr7:65403209 A/G cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs6474412 1.000 rs13280604 chr8:42559586 G/A cg25026480 chr8:42547641 NA 0.32 5.16 0.3 4.93e-7 Smoking behavior; CESC cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg05347473 chr6:146136440 FBXO30 0.59 7.63 0.42 4.24e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07168392 chr1:86861658 ODF2L 0.45 6.19 0.36 2.22e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg14345882 chr6:26364793 BTN3A2 0.41 5.35 0.31 1.94e-7 Intelligence (multi-trait analysis); CESC cis rs2228479 0.850 rs11645916 chr16:89835234 G/A cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg18337363 chr3:52569053 NT5DC2 0.28 5.05 0.3 8.27e-7 Intelligence (multi-trait analysis); CESC cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg11752832 chr7:134001865 SLC35B4 0.58 7.48 0.42 1.08e-12 Mean platelet volume; CESC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.69 0.33 3.32e-8 Bipolar disorder; CESC cis rs1215050 0.791 rs6838628 chr4:98809574 A/G cg17366294 chr4:99064904 C4orf37 0.39 5.06 0.3 7.75e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs763121 0.776 rs4820346 chr22:39125074 C/G cg14440974 chr22:39074834 NA 0.39 5.36 0.31 1.79e-7 Menopause (age at onset); CESC cis rs9660992 0.573 rs7531256 chr1:205191202 T/G cg21643547 chr1:205240462 TMCC2 -0.39 -5.48 -0.32 9.91e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs6973256 0.604 rs6975134 chr7:133531432 T/C cg10665199 chr7:133106180 EXOC4 0.43 6.06 0.35 4.73e-9 Intelligence (multi-trait analysis); CESC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs5769765 0.817 rs8142561 chr22:50291750 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.2 -0.3 4.01e-7 Schizophrenia; CESC cis rs6736093 0.966 rs34527376 chr2:112755699 C/T cg12686935 chr2:112915763 FBLN7 -0.43 -5.66 -0.33 3.94e-8 Coronary artery disease; CESC cis rs10170846 0.861 rs7571732 chr2:223538316 A/C cg25565276 chr2:223520875 FARSB -0.51 -7.21 -0.4 5.9e-12 Schizophrenia (inflammation and infection response interaction); CESC cis rs4727027 0.870 rs62507512 chr7:148799338 C/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.84 -0.39 5.49e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs763121 0.962 rs5757130 chr22:38937794 G/A cg06022373 chr22:39101656 GTPBP1 0.73 11.13 0.56 7.51e-24 Menopause (age at onset); CESC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.51 -0.32 8.3e-8 Aortic root size; CESC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg22903471 chr2:27725779 GCKR -0.5 -7.15 -0.4 8.58e-12 Total body bone mineral density; CESC cis rs9436747 0.566 rs112314233 chr1:65973295 C/G cg14976592 chr1:65886160 LEPROT;LEPR -0.43 -5.23 -0.31 3.38e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC trans rs2823962 0.687 rs2154727 chr21:18017766 T/C cg06419850 chr17:4688683 VMO1 -0.42 -6.13 -0.35 3.23e-9 Amyotrophic lateral sclerosis; CESC cis rs1881797 0.872 rs12408686 chr1:247691141 C/T cg11166453 chr1:247681781 NA 0.48 6.13 0.35 3.19e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs13102973 0.965 rs11099302 chr4:135880751 G/T cg14419869 chr4:135874104 NA 0.33 5.23 0.31 3.44e-7 Subjective well-being; CESC cis rs10416265 0.527 rs6510337 chr19:33545701 C/T cg17764715 chr19:33622953 WDR88 0.6 8.3 0.45 5.51e-15 Bone properties (heel); CESC cis rs7160336 0.604 rs10149539 chr14:74682227 C/T cg08255017 chr14:74727001 VSX2 -0.38 -5.53 -0.32 7.71e-8 Blood protein levels; CESC cis rs41005 0.805 rs10469618 chr2:8117622 C/T cg03155496 chr2:8117019 LOC339788 -0.37 -5.22 -0.31 3.65e-7 Response to anti-TNF therapy in rheumatoid arthritis; CESC cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg11812906 chr14:75593930 NEK9 -0.84 -12.97 -0.62 3.96e-30 Height; CESC cis rs9640161 0.750 rs59211922 chr7:150023790 T/G cg13722127 chr7:150037890 RARRES2 0.34 5.17 0.3 4.68e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs7274811 0.711 rs291700 chr20:31981849 C/T cg21523528 chr20:32077966 CBFA2T2 0.47 5.57 0.32 6.15e-8 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26420824 chr1:28562883 ATPIF1 -0.45 -6.25 -0.36 1.67e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg09658497 chr7:2847517 GNA12 -0.35 -5.09 -0.3 6.67e-7 Height; CESC cis rs8077889 0.871 rs8081101 chr17:41904332 C/T cg26893861 chr17:41843967 DUSP3 0.74 9.39 0.5 2.82e-18 Triglycerides; CESC cis rs4889855 0.614 rs9898443 chr17:78469357 C/T cg00066239 chr17:78472159 NA 0.4 5.64 0.33 4.29e-8 Fractional excretion of uric acid; CESC cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.752 rs6001190 chr22:39073811 T/C cg14440974 chr22:39074834 NA -0.42 -5.84 -0.34 1.52e-8 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04899896 chr4:79860379 PAQR3 -0.44 -6.12 -0.35 3.37e-9 Gambling; CESC cis rs763014 0.966 rs15564 chr16:677854 G/T cg00908189 chr16:619842 PIGQ 0.65 9.39 0.5 2.8e-18 Height; CESC cis rs2239547 0.657 rs12496077 chr3:52886241 G/A cg11645453 chr3:52864694 ITIH4 0.33 6.25 0.36 1.61e-9 Schizophrenia; CESC trans rs2727020 0.566 rs10839234 chr11:49185524 C/T cg03929089 chr4:120376271 NA -0.78 -11.85 -0.59 2.83e-26 Coronary artery disease; CESC cis rs965469 1.000 rs6037535 chr20:3270621 C/T cg25506879 chr20:3388711 C20orf194 -0.6 -6.35 -0.36 9.17e-10 IFN-related cytopenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24568548 chr11:43544500 NA -0.62 -7.55 -0.42 7.09e-13 Gut microbiome composition (summer); CESC cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg18904891 chr8:8559673 CLDN23 0.73 8.11 0.45 1.94e-14 Obesity-related traits; CESC cis rs763014 0.931 rs710925 chr16:633354 G/A cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC cis rs27434 0.821 rs28337 chr5:96125314 A/T cg16492584 chr5:96139282 ERAP1 -0.47 -6.54 -0.37 3.08e-10 Ankylosing spondylitis; CESC cis rs11608355 0.545 rs2302703 chr12:109898832 G/A cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs9640161 0.789 rs2098053 chr7:150043205 G/A cg10018233 chr7:150070692 REPIN1 0.38 5.3 0.31 2.39e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg23583168 chr7:148888333 NA -0.82 -12.47 -0.61 2.17e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.41 6.84 0.39 5.54e-11 Personality dimensions; CESC cis rs60843830 1.000 rs6709534 chr2:217334 G/C cg00108164 chr2:264199 ACP1;SH3YL1 0.75 9.46 0.5 1.69e-18 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs11098499 0.866 rs9995136 chr4:120286845 A/G cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg13206674 chr6:150067644 NUP43 0.41 5.93 0.34 9.4e-9 Lung cancer; CESC cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg12386194 chr3:101231763 SENP7 0.57 6.55 0.37 3e-10 Colonoscopy-negative controls vs population controls; CESC cis rs2832077 0.527 rs1048546 chr21:30244877 G/T cg24692254 chr21:30365293 RNF160 -0.52 -6.64 -0.38 1.74e-10 Cognitive test performance; CESC cis rs155076 0.938 rs9509633 chr13:21844482 G/C cg11317459 chr13:21872234 NA -1.01 -11.12 -0.56 7.88e-24 White matter hyperintensity burden; CESC cis rs644799 0.930 rs3802764 chr11:95514599 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.73 0.67 2.69e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs12142240 0.660 rs112560929 chr1:46822297 A/G cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC trans rs9354308 0.899 rs2814094 chr6:66536275 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.56 -6.31 -0.36 1.19e-9 Metabolite levels; CESC cis rs10242455 0.702 rs28668326 chr7:98998153 G/A cg25640893 chr7:99214727 ZNF498 1.07 6.65 0.38 1.68e-10 Blood metabolite levels; CESC cis rs72627509 1.000 rs57265257 chr4:57839280 A/T cg26694713 chr4:57773883 REST 0.54 5.13 0.3 5.49e-7 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs1538970 0.962 rs4660301 chr1:45820149 T/A cg03146154 chr1:46216737 IPP 0.45 5.39 0.31 1.54e-7 Platelet count; CESC cis rs2522056 1.000 rs2522047 chr5:131795882 G/T cg24060327 chr5:131705240 SLC22A5 0.59 6.63 0.38 1.85e-10 Lymphocyte counts;Fibrinogen; CESC cis rs11676348 0.818 rs6436031 chr2:218979259 T/C cg00012203 chr2:219082015 ARPC2 -0.57 -7.39 -0.41 1.96e-12 Ulcerative colitis; CESC cis rs9790314 0.695 rs7630763 chr3:160864865 T/C cg03342759 chr3:160939853 NMD3 -0.4 -5.49 -0.32 9.28e-8 Morning vs. evening chronotype; CESC cis rs854765 0.547 rs6502632 chr17:17913057 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.56 7.91 0.44 6.89e-14 Total body bone mineral density; CESC cis rs854765 0.547 rs2955378 chr17:17930253 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.51 6.68 0.38 1.41e-10 Total body bone mineral density; CESC cis rs858239 0.601 rs764534 chr7:23153935 C/T cg23682824 chr7:23144976 KLHL7 0.49 6.49 0.37 4.19e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.58 -0.37 2.56e-10 Bipolar disorder; CESC cis rs7208859 0.673 rs11653955 chr17:29033292 C/A cg19761014 chr17:28927070 LRRC37B2 0.79 6.36 0.36 8.58e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6901004 0.803 rs354539 chr6:111517829 T/C cg15721981 chr6:111408429 SLC16A10 -0.36 -5.19 -0.3 4.23e-7 Blood metabolite levels; CESC cis rs6500395 1.000 rs8059905 chr16:48629934 C/T cg04672837 chr16:48644449 N4BP1 0.53 6.85 0.39 5e-11 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg08470875 chr2:26401718 FAM59B -0.46 -5.14 -0.3 5.45e-7 Gut microbiome composition (summer); CESC cis rs9815354 0.812 rs77047799 chr3:41958895 T/C cg03022575 chr3:42003672 ULK4 0.67 6.09 0.35 3.97e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs34779708 0.966 rs10827493 chr10:35454976 C/T cg04310649 chr10:35416472 CREM -0.54 -6.78 -0.38 7.74e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs6499255 1.000 rs73579497 chr16:69824150 C/G cg15192750 chr16:69999425 NA 0.43 5.35 0.31 1.91e-7 IgE levels; CESC cis rs72781680 0.821 rs17046004 chr2:24144873 A/G cg08917208 chr2:24149416 ATAD2B 0.57 5.62 0.33 4.79e-8 Lymphocyte counts; CESC cis rs367943 0.698 rs9326900 chr5:112972859 A/G cg12552261 chr5:112820674 MCC 0.43 5.49 0.32 9.31e-8 Type 2 diabetes; CESC cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg24154853 chr7:158122151 PTPRN2 0.43 6.62 0.38 1.98e-10 Calcium levels; CESC cis rs920590 0.642 rs6993525 chr8:19671104 A/G cg17834443 chr8:19674713 INTS10 -0.47 -5.27 -0.31 2.87e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs4843185 0.576 rs381624 chr16:85728679 G/A cg05245094 chr16:85669572 KIAA0182 0.42 5.23 0.31 3.48e-7 Platelet distribution width; CESC cis rs2243480 1.000 rs160643 chr7:65558222 C/T cg18252515 chr7:66147081 NA -1.2 -11.72 -0.58 7.75e-26 Diabetic kidney disease; CESC cis rs7824557 0.767 rs2164272 chr8:11162496 A/C cg21775007 chr8:11205619 TDH 0.5 7.29 0.41 3.6e-12 Retinal vascular caliber; CESC cis rs1801251 0.778 rs2250665 chr2:233752639 A/T cg25237894 chr2:233734115 C2orf82 -0.5 -8.87 -0.48 1.14e-16 Coronary artery disease; CESC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg10691866 chr7:65817282 TPST1 -0.34 -5.46 -0.32 1.08e-7 Aortic root size; CESC cis rs2011503 1.000 rs1560687 chr19:19562902 G/A cg11584989 chr19:19387371 SF4 0.62 7.22 0.41 5.54e-12 Bipolar disorder; CESC cis rs523522 0.962 rs687873 chr12:121019634 G/A cg12219531 chr12:120966889 COQ5 0.76 10.07 0.53 2.15e-20 High light scatter reticulocyte count; CESC cis rs11249608 0.789 rs7704963 chr5:178436854 A/G cg21905437 chr5:178450457 ZNF879 0.49 6.99 0.39 2.22e-11 Pubertal anthropometrics; CESC cis rs7923609 0.869 rs9971352 chr10:65265108 A/T cg01631684 chr10:65280961 REEP3 -0.44 -5.5 -0.32 8.8e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs17253792 0.822 rs77741349 chr14:56097462 C/T cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs6499255 0.951 rs16958970 chr16:69627793 G/A cg15192750 chr16:69999425 NA 0.55 6.39 0.37 7.58e-10 IgE levels; CESC cis rs2204008 0.748 rs11180579 chr12:38237830 A/G cg26384229 chr12:38710491 ALG10B 0.73 10.35 0.54 2.55e-21 Bladder cancer; CESC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.97 0.48 5.62e-17 Bipolar disorder; CESC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg12311346 chr5:56204834 C5orf35 0.66 8.74 0.47 2.72e-16 Initial pursuit acceleration; CESC cis rs2243480 1.000 rs781156 chr7:65479141 C/A cg18252515 chr7:66147081 NA -1.19 -11.57 -0.58 2.56e-25 Diabetic kidney disease; CESC cis rs9900062 0.535 rs753917 chr17:62673136 C/T cg02598441 chr17:62777298 LOC146880 -0.56 -5.85 -0.34 1.47e-8 QT interval; CESC cis rs6466055 0.720 rs7357199 chr7:105019355 G/C cg04380332 chr7:105027541 SRPK2 -0.42 -5.36 -0.31 1.81e-7 Schizophrenia; CESC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.39 0.31 1.52e-7 Menopause (age at onset); CESC cis rs7809950 0.953 rs28687365 chr7:107106712 A/C cg23024343 chr7:107201750 COG5 -0.43 -6.11 -0.35 3.58e-9 Coronary artery disease; CESC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg13114125 chr14:105738426 BRF1 -0.89 -11.0 -0.56 2.0500000000000001e-23 Mean platelet volume;Platelet distribution width; CESC cis rs1023500 0.573 rs2413666 chr22:42459622 C/T cg15557168 chr22:42548783 NA -0.46 -6.53 -0.37 3.27e-10 Schizophrenia; CESC cis rs2304069 0.614 rs216140 chr5:149443298 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.5 6.84 0.39 5.42e-11 HIV-1 control; CESC cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg08564027 chr20:61660810 NA 0.9 15.44 0.69 8.75e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs74181299 0.684 rs12713532 chr2:65356552 G/C cg05010058 chr2:65284262 CEP68 -0.32 -5.13 -0.3 5.56e-7 Pulse pressure; CESC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg11764359 chr7:65958608 NA 0.94 14.96 0.68 4.34e-37 Aortic root size; CESC cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 5.21 0.3 3.84e-7 Osteoporosis; CESC cis rs769267 0.792 rs4808961 chr19:19577215 C/G cg03709012 chr19:19516395 GATAD2A 1.0 15.1 0.68 1.35e-37 Tonsillectomy; CESC cis rs7429990 0.965 rs2166770 chr3:48005673 A/C cg11946769 chr3:48343235 NME6 0.45 5.34 0.31 1.96e-7 Educational attainment (years of education); CESC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg18876405 chr7:65276391 NA -0.55 -7.28 -0.41 3.91e-12 Aortic root size; CESC cis rs113835537 0.935 rs76228630 chr11:66458676 T/C cg22134325 chr11:66188745 NPAS4 0.52 5.94 0.34 8.91e-9 Airway imaging phenotypes; CESC cis rs2066819 1.000 rs2695788 chr12:56697110 G/A cg26734620 chr12:56694298 CS -0.93 -9.55 -0.51 9.4e-19 Psoriasis vulgaris; CESC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg04944784 chr2:26401820 FAM59B -0.68 -7.49 -0.42 1.03e-12 Gut microbiome composition (summer); CESC cis rs7937682 0.855 rs521947 chr11:111492616 A/G cg09085632 chr11:111637200 PPP2R1B -0.95 -14.6 -0.67 8.26e-36 Primary sclerosing cholangitis; CESC cis rs568617 0.767 rs2231884 chr11:65656564 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.92 9.41 0.5 2.54e-18 Crohn's disease; CESC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg18402987 chr7:1209562 NA 0.7 8.04 0.44 3.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7177699 0.557 rs10083696 chr15:79124016 G/A cg04896959 chr15:78267971 NA 0.32 5.04 0.3 8.74e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs7191439 0.789 rs4598894 chr16:88776141 G/A cg27087555 chr16:88793112 FAM38A -1.34 -10.77 -0.55 1.16e-22 Plateletcrit; CESC cis rs6674970 0.518 rs6587552 chr1:151018861 C/T cg04469105 chr1:151031679 CDC42SE1;MLLT11 0.46 5.56 0.32 6.6e-8 Childhood ear infection; CESC cis rs7618915 0.501 rs55678971 chr3:52717229 T/A cg07507251 chr3:52567010 NT5DC2 0.4 6.94 0.39 2.98e-11 Bipolar disorder; CESC cis rs8027181 0.839 rs62017600 chr15:73072236 T/A cg25632853 chr15:73088954 NA 0.34 6.06 0.35 4.61e-9 Triglyceride levels; CESC cis rs6088590 0.603 rs6579186 chr20:33282198 G/C cg06115741 chr20:33292138 TP53INP2 0.53 6.62 0.38 1.99e-10 Coronary artery disease; CESC cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg14416269 chr4:6271139 WFS1 0.45 7.5 0.42 9.45e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs1728785 1.000 rs1728785 chr16:68591230 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -8.84 -0.48 1.36e-16 Ulcerative colitis; CESC cis rs67311347 1.000 rs73078169 chr3:40483798 G/A cg09455208 chr3:40491958 NA 0.49 8.07 0.44 2.53e-14 Renal cell carcinoma; CESC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg26338869 chr17:61819248 STRADA 0.69 9.11 0.49 2.04e-17 Prudent dietary pattern; CESC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg18016565 chr1:150552671 MCL1 0.33 5.08 0.3 7.3e-7 Tonsillectomy; CESC cis rs13191362 0.507 rs1079020 chr6:163066596 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.53 -6.22 -0.36 1.98e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg00385906 chr1:117910225 MAN1A2 0.42 6.09 0.35 4.04e-9 Bronchopulmonary dysplasia; CESC cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg24110177 chr3:50126178 RBM5 0.54 7.69 0.43 2.83e-13 Intelligence (multi-trait analysis); CESC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg09323728 chr8:95962352 TP53INP1 -0.42 -9.16 -0.49 1.5e-17 Type 2 diabetes; CESC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg16405210 chr4:1374714 KIAA1530 -0.42 -5.46 -0.32 1.12e-7 Longevity; CESC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg10074409 chr1:209979377 IRF6 0.4 5.32 0.31 2.16e-7 Cleft lip with or without cleft palate; CESC cis rs6800768 0.633 rs58523227 chr3:24116856 C/A cg10674438 chr3:24145617 LOC152024 -0.43 -5.83 -0.34 1.62e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7264396 0.676 rs1341603 chr20:34556216 A/G cg17201900 chr20:34330562 RBM39 0.5 5.2 0.3 3.93e-7 Total cholesterol levels; CESC cis rs473651 0.935 rs472357 chr2:239355454 A/G cg21699342 chr2:239360505 ASB1 -0.53 -9.47 -0.5 1.67e-18 Multiple system atrophy; CESC cis rs67478160 0.643 rs11160762 chr14:104255083 A/G cg08213375 chr14:104286397 PPP1R13B -0.54 -10.79 -0.55 9.95e-23 Schizophrenia; CESC cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg18904891 chr8:8559673 CLDN23 0.73 8.12 0.45 1.74e-14 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12448860 chr6:106959601 AIM1 0.58 6.22 0.36 1.95e-9 Gut microbiome composition (summer); CESC cis rs34172651 0.917 rs8049667 chr16:24773524 G/A cg06028605 chr16:24865363 SLC5A11 0.41 6.2 0.36 2.13e-9 Intelligence (multi-trait analysis); CESC cis rs12422267 0.536 rs12303484 chr12:132609558 G/A cg09764611 chr12:132620959 NA -0.5 -6.48 -0.37 4.39e-10 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs208520 1.000 rs208536 chr6:66963440 T/C cg07460842 chr6:66804631 NA -0.9 -10.34 -0.54 2.79e-21 Exhaled nitric oxide output; CESC trans rs9826463 0.590 rs1871349 chr3:142535409 C/G cg10107929 chr13:49550206 FNDC3A 0.51 6.33 0.36 1.02e-9 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs704 0.605 rs2227736 chr17:26693231 G/C cg10342447 chr17:26645325 TMEM97 -0.43 -5.93 -0.34 9.49e-9 Osteoprotegerin levels; CESC cis rs7577696 0.597 rs34197800 chr2:32389646 C/A cg02381751 chr2:32503542 YIPF4 -0.46 -5.46 -0.32 1.11e-7 Inflammatory biomarkers; CESC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg18876405 chr7:65276391 NA 0.47 6.27 0.36 1.47e-9 Aortic root size; CESC cis rs951366 0.677 rs1775140 chr1:205672107 C/A cg26354017 chr1:205819088 PM20D1 0.81 11.83 0.59 3.4e-26 Menarche (age at onset); CESC cis rs9925964 0.933 rs8050894 chr16:31104509 C/G cg02466173 chr16:30829666 NA 0.33 5.2 0.3 3.91e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9549367 0.789 rs9549699 chr13:113878263 T/A cg00898013 chr13:113819073 PROZ -0.49 -6.87 -0.39 4.59e-11 Platelet distribution width; CESC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.67 8.72 0.47 3.11e-16 Total body bone mineral density; CESC cis rs1799949 0.965 rs799912 chr17:41257134 T/C cg05368731 chr17:41323189 NBR1 0.53 7.43 0.42 1.48e-12 Menopause (age at onset); CESC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg17372223 chr3:52568218 NT5DC2 0.39 5.91 0.34 1.03e-8 Electroencephalogram traits; CESC cis rs36051895 0.589 rs10283734 chr9:5217139 A/T cg02405213 chr9:5042618 JAK2 -0.58 -6.99 -0.39 2.23e-11 Pediatric autoimmune diseases; CESC cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.48 6.21 0.36 2.07e-9 Colorectal cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg02113521 chr15:22892956 CYFIP1 0.5 6.92 0.39 3.49e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg22638593 chr5:131593259 PDLIM4 0.4 5.24 0.31 3.26e-7 Breast cancer; CESC cis rs9443645 0.901 rs4421161 chr6:79564219 A/G cg05283184 chr6:79620031 NA 0.46 6.95 0.39 2.83e-11 Intelligence (multi-trait analysis); CESC cis rs4604732 0.631 rs11490201 chr1:247626262 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs250677 0.687 rs2963485 chr5:148452043 A/G cg18129178 chr5:148520854 ABLIM3 0.47 5.37 0.31 1.73e-7 Breast cancer; CESC cis rs6502050 0.835 rs7502676 chr17:80093433 C/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.67 -0.38 1.49e-10 Life satisfaction; CESC cis rs9309473 0.528 rs2091022 chr2:73564570 G/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.34 -0.36 9.87e-10 Metabolite levels; CESC cis rs4835473 0.897 rs2323325 chr4:144758714 C/T cg25736465 chr4:144833511 NA 0.45 6.65 0.38 1.67e-10 Immature fraction of reticulocytes; CESC trans rs7943203 1.000 rs61913875 chr11:108298852 A/G cg01416241 chr5:148737479 PCYOX1L -0.48 -6.1 -0.35 3.72e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs6570726 0.935 rs372378 chr6:145816227 A/G cg05347473 chr6:146136440 FBXO30 0.5 6.71 0.38 1.15e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1775715 0.870 rs3847415 chr10:32219456 G/T cg18675610 chr10:32216311 ARHGAP12 0.36 5.51 0.32 8.56e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs2243480 1.000 rs1723269 chr7:65472786 C/G cg25894440 chr7:65020034 NA -0.67 -5.78 -0.33 2.11e-8 Diabetic kidney disease; CESC cis rs10870270 1.000 rs10870292 chr10:133770782 G/C cg26149184 chr10:133730230 NA 0.37 5.03 0.3 9.2e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg12756686 chr19:29218302 NA 0.58 7.52 0.42 8.38e-13 Methadone dose in opioid dependence; CESC cis rs8141529 0.732 rs5752798 chr22:29181868 A/G cg02153584 chr22:29168773 CCDC117 0.69 9.9 0.52 7.13e-20 Lymphocyte counts; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15238519 chr22:50683529 TUBGCP6 -0.48 -6.49 -0.37 4.2e-10 Ulcerative colitis; CESC cis rs4704187 0.687 rs4703657 chr5:74461850 T/G cg03227963 chr5:74354835 NA 0.3 5.35 0.31 1.89e-7 Response to amphetamines; CESC cis rs763014 0.931 rs3752568 chr16:628302 A/G cg00802000 chr16:706648 WDR90 -0.42 -6.36 -0.36 8.74e-10 Height; CESC cis rs6580649 0.941 rs17122612 chr12:48459488 C/G cg05342945 chr12:48394962 COL2A1 0.49 5.78 0.33 2.13e-8 Lung cancer; CESC trans rs11098499 0.774 rs73842616 chr4:120290683 G/A cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs6466055 0.720 rs1204056 chr7:104957761 G/A cg04380332 chr7:105027541 SRPK2 0.42 5.43 0.32 1.25e-7 Schizophrenia; CESC cis rs965513 1.000 rs1443438 chr9:100550028 T/C cg13688889 chr9:100608707 NA -0.6 -8.62 -0.47 6.31e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs7072216 0.763 rs3750601 chr10:100174561 C/A cg26618903 chr10:100175079 PYROXD2 -0.38 -5.82 -0.34 1.69e-8 Metabolite levels; CESC cis rs10129255 0.518 rs28378320 chr14:107216845 T/C cg23076370 chr14:107095027 NA -0.72 -11.14 -0.56 6.76e-24 Kawasaki disease; CESC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg02569458 chr12:86230093 RASSF9 0.56 8.07 0.44 2.43e-14 Major depressive disorder; CESC trans rs561341 1.000 rs55959993 chr17:30254771 C/G cg27661571 chr11:113659931 NA -0.87 -7.9 -0.44 7.5e-14 Hip circumference adjusted for BMI; CESC cis rs11098499 0.604 rs2389882 chr4:120566733 A/C cg09307838 chr4:120376055 NA 0.73 9.3 0.5 5.33e-18 Corneal astigmatism; CESC cis rs6088580 0.713 rs1884669 chr20:33171287 G/A cg24642439 chr20:33292090 TP53INP2 0.62 8.31 0.45 5.09e-15 Glomerular filtration rate (creatinine); CESC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg06028808 chr11:68637592 NA 0.45 5.34 0.31 1.96e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs854765 0.693 rs4924823 chr17:17764502 A/G cg04398451 chr17:18023971 MYO15A 0.68 10.07 0.53 2.1e-20 Total body bone mineral density; CESC cis rs9399135 0.967 rs6923765 chr6:135335176 C/G cg24558204 chr6:135376177 HBS1L -0.56 -7.79 -0.43 1.48e-13 Red blood cell count; CESC cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg06784218 chr1:46089804 CCDC17 0.29 5.1 0.3 6.36e-7 Red blood cell count;Reticulocyte count; CESC cis rs2243480 1.000 rs7792391 chr7:65773429 A/G cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs1788820 0.957 rs1652375 chr18:21109269 T/C cg14672496 chr18:21087552 C18orf8 0.53 7.11 0.4 1.07e-11 Body mass index; CESC cis rs9916302 0.706 rs8075737 chr17:37727316 C/T cg00129232 chr17:37814104 STARD3 0.53 5.68 0.33 3.53e-8 Glomerular filtration rate (creatinine); CESC cis rs6500602 0.627 rs11639998 chr16:4527109 T/C cg08645402 chr16:4508243 NA 0.42 5.94 0.34 8.95e-9 Schizophrenia; CESC cis rs1153858 1.000 rs7402650 chr15:45701895 C/T cg14582100 chr15:45693742 SPATA5L1 0.41 5.79 0.33 2.03e-8 Homoarginine levels; CESC cis rs9287719 0.967 rs6712406 chr2:10754420 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Depression; CESC cis rs7618501 0.521 rs2352984 chr3:49948728 T/C cg24308560 chr3:49941425 MST1R -0.6 -8.79 -0.47 1.98e-16 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18822446 chr2:157198283 NA 0.57 6.11 0.35 3.53e-9 Gut microbiome composition (summer); CESC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg08859206 chr1:53392774 SCP2 -0.59 -7.83 -0.43 1.19e-13 Monocyte count; CESC cis rs6964587 0.967 rs2040499 chr7:91809657 C/G cg17063962 chr7:91808500 NA -0.55 -7.66 -0.43 3.51e-13 Breast cancer; CESC cis rs9902453 0.904 rs8078638 chr17:28290358 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.01 0.52 3.23e-20 Coffee consumption (cups per day); CESC cis rs10089 1.000 rs4836366 chr5:127482494 A/T cg19767477 chr5:127420684 SLC12A2 -0.39 -5.18 -0.3 4.42e-7 Ileal carcinoids; CESC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.59 -0.32 5.66e-8 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21220614 chr22:43266108 NA 0.43 6.04 0.35 5.25e-9 Fibrinogen levels; CESC cis rs9486715 0.964 rs6921480 chr6:97066329 C/G cg18709589 chr6:96969512 KIAA0776 -0.46 -6.48 -0.37 4.56e-10 Headache; CESC cis rs7727544 0.735 rs272879 chr5:131670546 C/G cg24060327 chr5:131705240 SLC22A5 -0.67 -8.93 -0.48 7.2e-17 Blood metabolite levels; CESC cis rs12142240 0.659 rs72677591 chr1:46818219 T/G cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs9354308 0.840 rs1827157 chr6:66615761 A/G cg07460842 chr6:66804631 NA 0.64 7.08 0.4 1.31e-11 Metabolite levels; CESC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg08888203 chr3:10149979 C3orf24 0.49 6.24 0.36 1.68e-9 Alzheimer's disease; CESC cis rs9467773 0.595 rs12525810 chr6:26623511 T/TA cg11502198 chr6:26597334 ABT1 0.56 5.31 0.31 2.38e-7 Intelligence (multi-trait analysis); CESC cis rs897984 0.762 rs897986 chr16:30980902 T/C cg00531865 chr16:30841666 NA 0.5 6.84 0.39 5.3e-11 Dementia with Lewy bodies; CESC trans rs9858542 1.000 rs11130213 chr3:49712297 C/T cg21659725 chr3:3221576 CRBN -0.55 -6.72 -0.38 1.11e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.19 0.63 6.84e-31 Prudent dietary pattern; CESC cis rs2742540 0.524 rs2653562 chr11:8918160 A/T cg14711859 chr11:8959438 ASCL3 0.36 5.43 0.32 1.25e-7 Hematocrit; CESC cis rs3762637 1.000 rs9858558 chr3:122139742 G/A cg24169773 chr3:122142474 KPNA1 -0.51 -6.03 -0.35 5.56e-9 LDL cholesterol levels; CESC cis rs7208859 0.573 rs7223803 chr17:29077193 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20530339 chr18:21594203 TTC39C -0.54 -6.48 -0.37 4.46e-10 Response to antipsychotic treatment; CESC cis rs2645694 0.626 rs2703140 chr4:77830057 C/G cg10057126 chr4:77819792 ANKRD56 0.6 8.45 0.46 1.91e-15 Emphysema distribution in smoking; CESC cis rs11583043 0.918 rs11582211 chr1:101416871 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.54 5.92 0.34 9.72e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs1707322 0.648 rs4439382 chr1:46150805 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01596986 chr13:48611463 NUDT15 -0.46 -6.21 -0.36 2.03e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs10089 0.953 rs6875982 chr5:127529197 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.7 9.39 0.5 2.81e-18 Ileal carcinoids; CESC cis rs1728785 1.000 rs12918865 chr16:68566546 G/A cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg18758796 chr5:131593413 PDLIM4 0.39 5.38 0.31 1.67e-7 Breast cancer; CESC cis rs2243480 1.000 rs2420171 chr7:65637760 T/C cg12463550 chr7:65579703 CRCP -0.73 -5.71 -0.33 3.1e-8 Diabetic kidney disease; CESC cis rs847577 0.609 rs6965016 chr7:97807882 C/A cg21770322 chr7:97807741 LMTK2 0.85 14.36 0.66 5.78e-35 Breast cancer; CESC cis rs1832871 0.711 rs56043101 chr6:158682277 A/G cg07165851 chr6:158734300 TULP4 0.59 6.27 0.36 1.46e-9 Height; CESC cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.8 8.59 0.47 7.6e-16 Alzheimer's disease; CESC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg17427002 chr7:12443146 VWDE -0.53 -5.18 -0.3 4.34e-7 Coronary artery disease; CESC cis rs9611519 0.780 rs5751072 chr22:41656509 C/T cg03806693 chr22:41940476 POLR3H -0.55 -6.25 -0.36 1.66e-9 Neuroticism; CESC cis rs9309473 0.948 rs7566385 chr2:73756817 G/T cg20560298 chr2:73613845 ALMS1 -0.45 -6.11 -0.35 3.57e-9 Metabolite levels; CESC cis rs7592578 0.713 rs60915953 chr2:191331304 G/C cg27211696 chr2:191398769 TMEM194B -0.63 -5.65 -0.33 4.19e-8 Diastolic blood pressure; CESC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg25036284 chr2:26402008 FAM59B -0.59 -6.9 -0.39 3.85e-11 Gut microbiome composition (summer); CESC cis rs7216064 1.000 rs12451511 chr17:65874861 T/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.82 -0.48 1.55e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9329289 0.926 rs10903784 chr10:2541943 G/T cg15501526 chr10:2543763 NA -0.64 -11.58 -0.58 2.23e-25 Age-related hearing impairment; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14107975 chr11:96076498 MAML2 -0.42 -6.06 -0.35 4.57e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09371693 chr12:57855541 GLI1 0.57 6.3 0.36 1.22e-9 Gut microbiome composition (summer); CESC cis rs9359856 0.564 rs17228548 chr6:90439164 T/C cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.88 -0.34 1.23e-8 Bipolar disorder; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg02125554 chr16:90238222 NA -0.41 -6.13 -0.35 3.13e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs61931739 0.517 rs11052977 chr12:34035030 A/C cg26384229 chr12:38710491 ALG10B 0.59 8.08 0.44 2.33e-14 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.97 0.8 1.29e-61 Prudent dietary pattern; CESC cis rs7927771 0.524 rs7122182 chr11:47843133 A/C cg20307385 chr11:47447363 PSMC3 -0.58 -8.03 -0.44 3.12e-14 Subjective well-being; CESC cis rs854765 0.724 rs62072049 chr17:17906520 T/C cg04398451 chr17:18023971 MYO15A -0.68 -10.1 -0.53 1.73e-20 Total body bone mineral density; CESC cis rs3126085 0.935 rs6670717 chr1:152249956 T/C cg03465714 chr1:152285911 FLG 0.5 5.75 0.33 2.47e-8 Atopic dermatitis; CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg11965913 chr1:205819406 PM20D1 -0.69 -11.8 -0.59 4.11e-26 Monocyte percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21219744 chr4:44680344 GUF1 -0.47 -6.92 -0.39 3.44e-11 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00959725 chr1:33282965 S100PBP;YARS 0.6 6.9 0.39 3.75e-11 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg27170947 chr2:26402098 FAM59B -0.68 -7.96 -0.44 5.12e-14 Gut microbiome composition (summer); CESC cis rs7131987 0.903 rs7974221 chr12:29399448 A/G cg09582351 chr12:29534625 ERGIC2 -0.34 -5.39 -0.31 1.57e-7 QT interval; CESC cis rs116095464 0.558 rs9312957 chr5:202194 C/T cg22496380 chr5:211416 CCDC127 -0.93 -10.2 -0.53 8.09e-21 Breast cancer; CESC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg23985595 chr17:80112537 CCDC57 0.41 6.42 0.37 6.41e-10 Life satisfaction; CESC cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg25517755 chr10:38738941 LOC399744 -0.49 -6.36 -0.36 8.84e-10 Extrinsic epigenetic age acceleration; CESC cis rs7555523 0.830 rs1547725 chr1:165670958 T/C cg24409356 chr1:165738333 TMCO1 0.81 6.78 0.38 7.67e-11 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg08888203 chr3:10149979 C3orf24 0.53 6.72 0.38 1.11e-10 Alzheimer's disease; CESC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg18099408 chr3:52552593 STAB1 -0.31 -5.09 -0.3 6.65e-7 Bipolar disorder; CESC cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -7.54 -0.42 7.32e-13 Personality dimensions; CESC trans rs2727020 0.595 rs10466496 chr11:49501514 C/T cg03929089 chr4:120376271 NA -0.85 -13.5 -0.64 5.83e-32 Coronary artery disease; CESC cis rs34779708 0.931 rs3740083 chr10:35320383 C/T cg03585969 chr10:35415529 CREM 0.76 10.17 0.53 9.87e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs909002 0.849 rs6425777 chr1:32105447 G/C cg13919466 chr1:32135498 COL16A1 -0.47 -8.05 -0.44 2.79e-14 Intelligence (multi-trait analysis); CESC cis rs959260 1.000 rs4789185 chr17:73383368 C/T cg20590849 chr17:73267439 MIF4GD -0.57 -6.73 -0.38 1.07e-10 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22162010 chr1:113249994 RHOC 0.55 6.22 0.36 1.92e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs911555 0.755 rs35233301 chr14:103885291 A/G cg12935359 chr14:103987150 CKB 0.63 9.16 0.49 1.51e-17 Intelligence (multi-trait analysis); CESC cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg19052272 chr2:3704530 ALLC 0.51 6.59 0.38 2.3e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs1707322 0.752 rs6662164 chr1:46146230 T/A cg03146154 chr1:46216737 IPP 0.77 10.78 0.55 1.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19123408 chr17:7232769 NEURL4 -0.42 -6.15 -0.35 2.82e-9 Gambling; CESC cis rs9682041 0.688 rs7621787 chr3:170146862 T/A cg11886554 chr3:170076028 SKIL 0.92 7.07 0.4 1.35e-11 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs7116495 0.609 rs628025 chr11:71802351 A/C cg26138937 chr11:71823887 C11orf51 -1.36 -8.51 -0.46 1.28e-15 Severe influenza A (H1N1) infection; CESC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg19046167 chr17:80928561 B3GNTL1 0.41 5.47 0.32 1.04e-7 Breast cancer; CESC cis rs8017423 0.967 rs2151748 chr14:90694897 G/C cg14092571 chr14:90743983 NA -0.55 -7.91 -0.44 7.09e-14 Mortality in heart failure; CESC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.46 0.42 1.24e-12 Tonsillectomy; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg15147215 chr3:52552868 STAB1 -0.31 -5.55 -0.32 6.79e-8 Bipolar disorder; CESC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg14773178 chr5:1868261 NA 0.31 5.57 0.32 6.41e-8 Cardiovascular disease risk factors; CESC cis rs9303401 0.659 rs34818467 chr17:56643109 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.83 -10.44 -0.54 1.36e-21 Cognitive test performance; CESC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg13393036 chr8:95962371 TP53INP1 0.37 6.9 0.39 3.71e-11 Type 2 diabetes; CESC cis rs6460942 1.000 rs7791634 chr7:12401482 A/T cg02935154 chr7:12443704 VWDE -0.57 -6.18 -0.35 2.42e-9 Coronary artery disease; CESC cis rs748404 0.560 rs1869258 chr15:43803621 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.58 7.37 0.41 2.18e-12 Lung cancer; CESC cis rs77106637 0.860 rs1552224 chr11:72433098 A/C cg03713592 chr11:72463424 ARAP1 1.22 11.1 0.56 9.43e-24 Type 2 diabetes; CESC cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg12365402 chr11:9010492 NRIP3 0.43 7.02 0.4 1.9e-11 Hemoglobin concentration; CESC cis rs6500602 1.000 rs7204827 chr16:4467533 C/T cg08645402 chr16:4508243 NA 0.45 6.87 0.39 4.69e-11 Schizophrenia; CESC cis rs6121246 0.522 rs6088736 chr20:30195166 C/G cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.04 0.4 1.62e-11 Bipolar disorder; CESC cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg12386194 chr3:101231763 SENP7 0.42 5.34 0.31 2.04e-7 Colorectal cancer; CESC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg21433313 chr16:3507492 NAT15 -0.47 -7.67 -0.43 3.32e-13 Tuberculosis; CESC cis rs7824557 0.602 rs7820895 chr8:11206262 T/C cg21775007 chr8:11205619 TDH 0.58 8.93 0.48 7.48e-17 Retinal vascular caliber; CESC cis rs6088580 0.609 rs6059845 chr20:33036500 G/A cg08999081 chr20:33150536 PIGU 0.66 11.66 0.58 1.25e-25 Glomerular filtration rate (creatinine); CESC cis rs1707322 1.000 rs3922887 chr1:46473802 A/G cg03146154 chr1:46216737 IPP 0.73 9.95 0.52 5.12e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9287719 0.967 rs6750891 chr2:10738563 T/C cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg25405998 chr7:65216604 CCT6P1 0.51 6.49 0.37 4.11e-10 Calcium levels; CESC cis rs2637266 0.783 rs2583070 chr10:78518555 C/T cg18941641 chr10:78392320 NA 0.43 8.42 0.46 2.39e-15 Pulmonary function; CESC cis rs769267 0.930 rs747050 chr19:19584987 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.87 0.34 1.28e-8 Tonsillectomy; CESC cis rs28374715 0.617 rs28626792 chr15:41562218 A/G cg18705301 chr15:41695430 NDUFAF1 -0.53 -7.59 -0.42 5.57e-13 Ulcerative colitis; CESC cis rs3733585 0.699 rs6852441 chr4:9973744 C/T cg02734326 chr4:10020555 SLC2A9 -0.4 -5.69 -0.33 3.43e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9300255 0.739 rs1969354 chr12:123741776 T/C cg19016782 chr12:123741754 C12orf65 -0.48 -6.9 -0.39 3.71e-11 Neutrophil percentage of white cells; CESC cis rs4253772 0.637 rs9627295 chr22:46650100 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.18 0.45 1.16e-14 LDL cholesterol;Cholesterol, total; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20299236 chr22:32870557 FBXO7 -0.42 -6.18 -0.35 2.34e-9 Gambling; CESC cis rs7523050 0.730 rs12726126 chr1:109436128 A/G cg08274380 chr1:109419600 GPSM2 0.91 6.41 0.37 6.51e-10 Fat distribution (HIV); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22767166 chr8:49833685 SNAI2 -0.38 -6.67 -0.38 1.44e-10 Gut microbiota (bacterial taxa); CESC cis rs300703 0.515 rs440617 chr2:189818 A/G cg21211680 chr2:198530 NA -0.91 -10.78 -0.55 1.02e-22 Blood protein levels; CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.95 -16.01 -0.7 8.35e-41 Prudent dietary pattern; CESC cis rs546131 0.928 rs550313 chr11:34830919 C/T cg11058730 chr11:34937778 PDHX;APIP 0.47 5.84 0.34 1.52e-8 Lung disease severity in cystic fibrosis; CESC cis rs11785400 0.731 rs9720504 chr8:143725502 T/C cg24634471 chr8:143751801 JRK 0.46 5.82 0.34 1.73e-8 Schizophrenia; CESC cis rs4843747 0.671 rs4075599 chr16:88107423 C/G cg17633681 chr16:88106987 BANP 0.67 9.01 0.48 4.34e-17 Menopause (age at onset); CESC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg04414720 chr1:150670196 GOLPH3L 0.56 7.44 0.42 1.41e-12 Melanoma; CESC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg22535103 chr8:58192502 C8orf71 -0.99 -12.69 -0.61 3.79e-29 Developmental language disorder (linguistic errors); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg13850925 chr2:191666976 NA 0.39 6.34 0.36 9.64e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9443645 0.527 rs9352691 chr6:79785607 C/T cg05283184 chr6:79620031 NA -0.38 -5.46 -0.32 1.09e-7 Intelligence (multi-trait analysis); CESC cis rs7267979 1.000 rs2257420 chr20:25275890 C/A cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs36051895 0.587 rs7019418 chr9:5259847 G/C cg02405213 chr9:5042618 JAK2 -0.52 -6.41 -0.37 6.8e-10 Pediatric autoimmune diseases; CESC cis rs6456156 0.805 rs6909252 chr6:167527097 C/T cg07741184 chr6:167504864 NA -0.31 -5.2 -0.3 3.98e-7 Primary biliary cholangitis; CESC trans rs9329221 0.537 rs6601414 chr8:9976748 G/A cg15556689 chr8:8085844 FLJ10661 0.49 6.24 0.36 1.72e-9 Neuroticism; CESC cis rs7192750 0.652 rs150617 chr16:72139396 T/C cg14768367 chr16:72042858 DHODH 0.73 5.73 0.33 2.7e-8 LDL cholesterol levels;Total cholesterol levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02370978 chr2:86333167 PTCD3;POLR1A -0.48 -6.17 -0.35 2.49e-9 Ulcerative colitis; CESC cis rs4689388 0.926 rs3821940 chr4:6286711 C/A cg14416269 chr4:6271139 WFS1 0.45 7.45 0.42 1.36e-12 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs4332037 0.950 rs11767515 chr7:1941051 C/T cg11693508 chr17:37793320 STARD3 0.67 6.4 0.37 6.96e-10 Bipolar disorder; CESC cis rs9399135 0.967 rs59329760 chr6:135342437 G/A cg24558204 chr6:135376177 HBS1L 0.52 7.28 0.41 3.9e-12 Red blood cell count; CESC cis rs72781680 1.000 rs7594510 chr2:24173377 A/G cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs4604732 0.536 rs10925056 chr1:247650472 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.4 5.12 0.3 5.94e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4730250 0.707 rs6960148 chr7:106786142 A/G cg02696742 chr7:106810147 HBP1 0.56 5.29 0.31 2.59e-7 Osteoarthritis; CESC cis rs62229266 0.839 rs11088335 chr21:37470335 C/T cg08632701 chr21:37451849 NA -0.39 -5.37 -0.31 1.71e-7 Mitral valve prolapse; CESC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.3 0.31 2.39e-7 Menopause (age at onset); CESC cis rs2204008 0.744 rs11514071 chr12:38392076 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.46 0.54 1.17e-21 Bladder cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24224884 chr10:99447166 AVPI1 -0.45 -6.2 -0.36 2.21e-9 Fibrinogen levels; CESC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg26335602 chr6:28129616 ZNF389 0.37 5.3 0.31 2.4e-7 Parkinson's disease; CESC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg20151795 chr6:28129481 ZNF389 0.39 5.24 0.31 3.32e-7 Depression; CESC cis rs9457247 0.565 rs12178491 chr6:167512474 C/T cg07741184 chr6:167504864 NA 0.43 7.7 0.43 2.68e-13 Crohn's disease; CESC cis rs4835473 0.800 rs2089839 chr4:144902108 G/A cg25736465 chr4:144833511 NA 0.4 6.2 0.36 2.13e-9 Immature fraction of reticulocytes; CESC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.47 -0.37 4.79e-10 Life satisfaction; CESC cis rs7940866 0.804 rs6590540 chr11:130805444 T/C cg12179176 chr11:130786555 SNX19 0.67 10.39 0.54 2.02e-21 Schizophrenia; CESC trans rs1814175 0.935 rs7482690 chr11:49648814 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -16.94 -0.72 3.96e-44 Height; CESC cis rs2281845 0.507 rs11589642 chr1:201100748 A/G cg06714761 chr1:201096289 NA -0.47 -7.31 -0.41 3.16e-12 Permanent tooth development; CESC cis rs425277 1.000 rs262641 chr1:2104981 C/T cg23803603 chr1:2058230 PRKCZ -0.31 -5.12 -0.3 5.82e-7 Height; CESC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg14393609 chr7:65229607 NA 0.51 7.01 0.4 2.03e-11 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02306730 chr19:39109456 MAP4K1;EIF3K 0.73 8.13 0.45 1.63e-14 Gut microbiome composition (summer); CESC cis rs4919044 0.808 rs2486687 chr10:94778283 T/C cg16508068 chr10:94451736 HHEX -0.5 -5.49 -0.32 9.61e-8 Coronary artery disease; CESC cis rs4474465 0.850 rs11237546 chr11:78266924 T/C cg27205649 chr11:78285834 NARS2 0.44 5.7 0.33 3.24e-8 Alzheimer's disease (survival time); CESC cis rs9291683 0.588 rs12647117 chr4:10022059 T/C cg02734326 chr4:10020555 SLC2A9 0.49 7.03 0.4 1.74e-11 Bone mineral density; CESC cis rs854765 0.547 rs4365348 chr17:17912548 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.54 7.7 0.43 2.77e-13 Total body bone mineral density; CESC trans rs1814175 0.817 rs10769641 chr11:49960141 A/G cg03929089 chr4:120376271 NA -0.93 -15.75 -0.7 6.66e-40 Height; CESC cis rs593982 1.000 rs665191 chr11:65493658 G/A cg08755490 chr11:65554678 OVOL1 1.23 13.78 0.65 6.27e-33 Atopic dermatitis; CESC cis rs9987353 0.589 rs1053036 chr8:9060077 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -5.85 -0.34 1.44e-8 Recombination measurement; CESC cis rs7520050 0.966 rs7556436 chr1:46363880 C/T cg24296786 chr1:45957014 TESK2 -0.44 -5.62 -0.33 4.76e-8 Red blood cell count;Reticulocyte count; CESC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg18876405 chr7:65276391 NA 0.47 5.68 0.33 3.46e-8 Aortic root size; CESC cis rs4906332 0.966 rs59858038 chr14:103867102 C/T cg09975044 chr14:104007538 NA 0.46 6.34 0.36 9.93e-10 Coronary artery disease; CESC cis rs941873 0.868 rs7332 chr10:81114060 G/A cg09469691 chr10:81107165 PPIF 0.56 7.56 0.42 6.79e-13 Height; CESC cis rs57502260 0.704 rs17149179 chr11:68351722 C/T cg20283391 chr11:68216788 NA -0.65 -5.37 -0.31 1.74e-7 Total body bone mineral density (age 45-60); CESC cis rs3806843 0.966 rs2240693 chr5:140183325 G/C cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.26 -0.31 2.95e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2119480 0.731 rs378399 chr13:111308040 G/C cg16216153 chr13:111290848 CARKD -0.36 -5.43 -0.32 1.26e-7 Diastolic blood pressure; CESC cis rs854765 0.647 rs7211714 chr17:17986955 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.16 0.35 2.7e-9 Total body bone mineral density; CESC cis rs4588572 0.643 rs1159929 chr5:77768820 A/G cg11547950 chr5:77652471 NA 0.45 5.66 0.33 3.83e-8 Triglycerides; CESC cis rs1050631 1.000 rs1789550 chr18:33699553 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 -0.41 -5.31 -0.31 2.31e-7 Esophageal squamous cell cancer (length of survival); CESC trans rs8014252 0.667 rs10150707 chr14:70843703 C/G cg03123320 chr1:229394665 NA -0.49 -6.44 -0.37 5.61e-10 Plasma estrone levels in resected estrogen-receptor positive breast cancer; CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.37 5.46 0.32 1.1e-7 Electroencephalogram traits; CESC cis rs1003719 0.715 rs2835642 chr21:38539066 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.98 -0.44 4.49e-14 Eye color traits; CESC cis rs9913156 0.793 rs55884013 chr17:4579301 G/A cg00122941 chr17:4613640 ARRB2 0.81 9.13 0.49 1.87e-17 Lymphocyte counts; CESC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg09197432 chr4:183729176 NA 0.56 5.6 0.33 5.29e-8 Pediatric autoimmune diseases; CESC cis rs7605827 0.930 rs722328 chr2:15657164 T/C cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.7e-10 Educational attainment (years of education); CESC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg19622623 chr12:86230825 RASSF9 -0.47 -6.08 -0.35 4.25e-9 Major depressive disorder; CESC cis rs992157 0.764 rs2015863 chr2:219185161 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.56 -7.18 -0.4 7.02e-12 Colorectal cancer; CESC cis rs881375 0.967 rs2109896 chr9:123683106 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.05 0.3 8.31e-7 Rheumatoid arthritis; CESC cis rs950169 0.610 rs34529571 chr15:84691807 A/G cg17507749 chr15:85114479 UBE2QP1 0.6 5.92 0.34 9.68e-9 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22215737 chr17:4643257 CXCL16;ZMYND15 0.51 6.29 0.36 1.34e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg26338869 chr17:61819248 STRADA 0.67 8.77 0.47 2.24e-16 Prudent dietary pattern; CESC cis rs9300255 0.620 rs7313483 chr12:123726834 C/T cg05973401 chr12:123451056 ABCB9 0.5 5.54 0.32 7.18e-8 Neutrophil percentage of white cells; CESC cis rs2289328 0.943 rs12905240 chr15:40672145 C/T cg13931752 chr15:40660718 DISP2 0.46 5.47 0.32 1.07e-7 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24280607 chr15:41709584 RTF1 0.44 6.16 0.35 2.67e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg06420487 chr17:61919686 SMARCD2 0.44 5.35 0.31 1.88e-7 Height; CESC cis rs1018836 0.923 rs7837230 chr8:91574281 C/T cg16814680 chr8:91681699 NA -0.69 -9.74 -0.51 2.4e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs8040855 0.576 rs62022528 chr15:85535261 C/T cg08123816 chr15:85640762 PDE8A -0.42 -5.88 -0.34 1.2e-8 Bulimia nervosa; CESC cis rs7615952 0.515 rs7637246 chr3:125678706 A/G cg05084668 chr3:125655381 ALG1L -0.53 -5.77 -0.33 2.22e-8 Blood pressure (smoking interaction); CESC cis rs10851478 0.872 rs12591659 chr15:49933823 G/A cg08060515 chr15:49448048 GALK2;COPS2 0.43 5.26 0.31 3e-7 Oral cavity cancer; CESC cis rs12142240 0.667 rs41293287 chr1:46808852 C/T cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg17372223 chr3:52568218 NT5DC2 0.43 6.36 0.36 9.03e-10 Bipolar disorder; CESC cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.57 0.42 6.29e-13 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21123913 chr4:89513664 HERC3 -0.52 -6.67 -0.38 1.49e-10 Fibrinogen levels; CESC cis rs11711311 1.000 rs2712348 chr3:113460614 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.64 8.85 0.48 1.26e-16 IgG glycosylation; CESC cis rs6580649 0.941 rs72644841 chr12:48411987 A/G cg24011408 chr12:48396354 COL2A1 -0.41 -5.18 -0.3 4.47e-7 Lung cancer; CESC cis rs56104184 0.668 rs73063523 chr19:49408943 T/C cg15549821 chr19:49342101 PLEKHA4 -0.57 -5.76 -0.33 2.33e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs2777491 0.957 rs7181911 chr15:41674060 T/C cg02330683 chr15:41787940 ITPKA 0.43 6.2 0.36 2.2e-9 Ulcerative colitis; CESC cis rs9399137 0.507 rs4451150 chr6:135279063 T/G cg24558204 chr6:135376177 HBS1L 0.66 8.68 0.47 4.24e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16782613 chr7:44058922 POLR2J4 -0.48 -6.27 -0.36 1.45e-9 Ulcerative colitis; CESC cis rs7640424 0.649 rs1369555 chr3:107901184 A/G cg09227934 chr3:107805635 CD47 0.45 5.77 0.33 2.16e-8 Body mass index; CESC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg24531977 chr5:56204891 C5orf35 -0.88 -11.14 -0.56 6.81e-24 Initial pursuit acceleration; CESC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg24879335 chr3:133465180 TF 0.37 6.47 0.37 4.62e-10 Iron status biomarkers; CESC cis rs12612435 0.518 rs35309679 chr2:137064759 C/T cg23554286 chr2:137951070 THSD7B 0.64 5.31 0.31 2.34e-7 Takotsubo syndrome; CESC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg00129232 chr17:37814104 STARD3 0.51 6.67 0.38 1.46e-10 Glomerular filtration rate (creatinine); CESC cis rs1348850 0.597 rs13014417 chr2:178417835 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.66 6.79 0.38 7.41e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7617773 0.780 rs4479622 chr3:48338173 C/T cg11946769 chr3:48343235 NME6 0.89 12.11 0.6 3.63e-27 Coronary artery disease; CESC cis rs71391092 1 rs71391092 chr16:74567075 C/G cg01733217 chr16:74700730 RFWD3 -0.66 -6.01 -0.35 5.96e-9 Schizophrenia; CESC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.37e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4595586 0.505 rs12823590 chr12:39399750 A/T cg26384229 chr12:38710491 ALG10B 0.58 7.81 0.43 1.35e-13 Morning vs. evening chronotype; CESC cis rs77741769 0.529 rs10849791 chr12:121235280 T/C cg02419362 chr12:121203948 SPPL3 0.35 5.72 0.33 2.83e-8 Mean corpuscular volume; CESC cis rs2304069 0.545 rs13168011 chr5:149392377 C/T cg12661370 chr5:149340060 SLC26A2 0.47 6.27 0.36 1.49e-9 HIV-1 control; CESC cis rs1005277 0.505 rs719569 chr10:38154415 T/G cg25427524 chr10:38739819 LOC399744 0.68 10.16 0.53 1.05e-20 Extrinsic epigenetic age acceleration; CESC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg25072359 chr17:41440525 NA 0.5 7.55 0.42 6.88e-13 Menopause (age at onset); CESC cis rs3733585 0.699 rs6449177 chr4:9968050 T/C cg11266682 chr4:10021025 SLC2A9 -0.57 -10.49 -0.54 9.13e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg21280719 chr6:42927975 GNMT -0.3 -6.94 -0.39 3.09e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9314323 0.767 rs6557915 chr8:26209062 C/A cg13160058 chr8:26243215 BNIP3L -0.32 -5.03 -0.3 8.87e-7 Red cell distribution width; CESC cis rs6831352 0.877 rs2602890 chr4:100043179 C/T cg12011299 chr4:100065546 ADH4 0.59 6.58 0.37 2.55e-10 Alcohol dependence; CESC cis rs56104184 0.775 rs73061689 chr19:49397214 C/T cg21252483 chr19:49399788 TULP2 -0.53 -5.72 -0.33 2.94e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.77 8.27 0.45 6.58e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs660498 0.507 rs34354872 chr10:27735673 T/G cg25705717 chr10:27608719 NA 0.48 5.77 0.33 2.17e-8 Asthma (childhood onset); CESC cis rs2880765 0.743 rs16940052 chr15:86006674 G/A cg10818794 chr15:86012489 AKAP13 -0.33 -5.1 -0.3 6.63e-7 Coronary artery disease; CESC cis rs8114671 0.562 rs6058120 chr20:33402829 A/G cg06115741 chr20:33292138 TP53INP2 0.47 5.65 0.33 4.04e-8 Height; CESC cis rs2243480 1.000 rs73142122 chr7:65311298 C/A cg13147721 chr7:65941812 NA -0.9 -8.76 -0.47 2.35e-16 Diabetic kidney disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03028685 chr10:99078963 FRAT1 -0.47 -7.33 -0.41 2.83e-12 Gambling; CESC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.45 0.32 1.15e-7 Bipolar disorder; CESC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg18876405 chr7:65276391 NA 0.53 7.32 0.41 3.01e-12 Aortic root size; CESC cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg11644478 chr21:40555479 PSMG1 -0.56 -7.66 -0.43 3.43e-13 Menarche (age at onset); CESC cis rs9314323 0.964 rs3808576 chr8:26266834 G/A cg11498726 chr8:26250323 BNIP3L -0.44 -6.47 -0.37 4.73e-10 Red cell distribution width; CESC cis rs12200560 0.505 rs984519 chr6:97076223 A/G cg06623918 chr6:96969491 KIAA0776 -0.49 -6.4 -0.37 7.08e-10 Coronary heart disease; CESC cis rs4409675 0.576 rs10751725 chr1:28216191 A/C cg23691781 chr1:28212827 C1orf38 -0.28 -5.6 -0.33 5.36e-8 Corneal astigmatism; CESC cis rs1005224 0.889 rs2059382 chr14:76158916 T/C cg25116370 chr14:76127843 TTLL5;C14orf1 -0.43 -5.98 -0.34 7.22e-9 Large artery stroke; CESC cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg18512352 chr11:47633146 NA 0.43 6.2 0.36 2.13e-9 Subjective well-being; CESC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg05368731 chr17:41323189 NBR1 0.79 11.2 0.57 4.27e-24 Menopause (age at onset); CESC cis rs853679 0.599 rs149990 chr6:27998258 G/A cg20933634 chr6:27740509 NA 0.58 5.16 0.3 4.82e-7 Depression; CESC cis rs1003719 0.715 rs4261789 chr21:38503762 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.54 -0.46 1.04e-15 Eye color traits; CESC cis rs1034435 0.755 rs5767171 chr22:48891881 A/G cg05992904 chr22:48892994 FAM19A5 -0.57 -10.22 -0.53 6.78e-21 Late-onset Alzheimer's disease; CESC cis rs2204008 0.837 rs11495722 chr12:38337245 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.73 0.38 1.05e-10 Bladder cancer; CESC cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg16447950 chr5:562315 NA -0.58 -6.05 -0.35 4.93e-9 Lung disease severity in cystic fibrosis; CESC trans rs7980799 0.682 rs1580396 chr12:33615841 C/A cg26384229 chr12:38710491 ALG10B -0.55 -7.81 -0.43 1.32e-13 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs9303280 0.806 rs34189114 chr17:38032460 C/T cg20243544 chr17:37824526 PNMT 0.53 6.93 0.39 3.14e-11 Self-reported allergy; CESC cis rs10129255 0.917 rs8022493 chr14:107190057 C/T cg07958169 chr14:107095056 NA -0.4 -5.54 -0.32 7.3e-8 Kawasaki disease; CESC cis rs7208859 0.673 rs216440 chr17:28928309 A/T cg04154034 chr17:28927549 LRRC37B2 0.61 5.93 0.34 9.61e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs28489187 0.577 rs3920521 chr1:85848866 A/C cg16011679 chr1:85725395 C1orf52 0.45 5.32 0.31 2.21e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs6582630 0.502 rs3902522 chr12:38271203 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.61 0.33 5.13e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg05535760 chr7:792225 HEATR2 0.75 7.85 0.43 1e-13 Cerebrospinal P-tau181p levels; CESC cis rs12295403 1.000 rs12789252 chr11:18690389 C/T cg09887367 chr11:18690185 NA -0.38 -5.62 -0.33 4.95e-8 Ovarian reserve; CESC cis rs2276314 0.857 rs28431958 chr18:33578401 T/G cg19628046 chr18:33552617 C18orf21 0.5 5.49 0.32 9.29e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs116988415 0.584 rs1875054 chr14:65255066 G/A cg25083366 chr14:65239357 SPTB 0.7 5.29 0.31 2.6e-7 Daytime sleep phenotypes; CESC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.94 0.65 1.64e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg19592336 chr6:28129416 ZNF389 0.61 8.29 0.45 5.77e-15 Depression; CESC cis rs9905704 0.647 rs33922512 chr17:57114148 C/G cg12560992 chr17:57184187 TRIM37 -0.61 -7.52 -0.42 8.64e-13 Testicular germ cell tumor; CESC cis rs60843830 0.550 rs300751 chr2:209063 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.54 7.0 0.4 2.08e-11 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs2011503 1.000 rs34067609 chr19:19653524 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg12463550 chr7:65579703 CRCP -0.55 -7.03 -0.4 1.79e-11 Aortic root size; CESC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg18305652 chr10:134549665 INPP5A 0.47 6.68 0.38 1.43e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs1549733 0.577 rs16857851 chr2:218418350 A/G cg23408253 chr19:17438755 ANO8 -0.46 -6.01 -0.35 6.22e-9 Optic disc area; CESC cis rs637571 0.565 rs570387 chr11:65637076 T/C cg26695010 chr11:65641043 EFEMP2 0.5 6.11 0.35 3.58e-9 Eosinophil percentage of white cells; CESC cis rs1008375 1.000 rs10939747 chr4:17691166 C/A cg16339924 chr4:17578868 LAP3 0.64 7.7 0.43 2.69e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10823500 0.777 rs10999196 chr10:71982305 T/C cg02100629 chr10:71892760 AIFM2 -0.32 -5.13 -0.3 5.6e-7 Blood protein levels; CESC trans rs10085978 0.604 rs10099944 chr8:143234817 A/G cg27186271 chr11:842611 TSPAN4;POLR2L 0.53 6.09 0.35 4e-9 Mosquito bite size; CESC cis rs6430585 0.941 rs60963894 chr2:136539670 T/G cg07169764 chr2:136633963 MCM6 0.97 12.27 0.6 1.02e-27 Corneal structure; CESC cis rs10392 0.543 rs16987679 chr20:37557185 G/C cg27552599 chr20:37590471 DHX35 0.39 5.92 0.34 9.73e-9 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs1620921 0.505 rs12214254 chr6:161195932 C/A cg01280913 chr6:161186852 NA -0.4 -6.12 -0.35 3.42e-9 Lipoprotein (a) - cholesterol levels; CESC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg03576123 chr11:487126 PTDSS2 -1.09 -10.78 -0.55 1.02e-22 Body mass index; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg02239891 chr2:214016774 IKZF2 0.42 6.2 0.36 2.15e-9 Vertical cup-disc ratio; CESC cis rs7089973 0.872 rs60820172 chr10:116625891 C/T cg23260525 chr10:116636907 FAM160B1 0.38 6.42 0.37 6.35e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs950776 0.616 rs3743077 chr15:78894896 C/T cg24631222 chr15:78858424 CHRNA5 -0.44 -5.42 -0.32 1.32e-7 Sudden cardiac arrest; CESC cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg01579765 chr21:45077557 HSF2BP 0.47 8.13 0.45 1.69e-14 Mean corpuscular volume; CESC cis rs7712401 0.560 rs13168225 chr5:122347264 C/T cg19412675 chr5:122181750 SNX24 -0.43 -5.07 -0.3 7.41e-7 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05992347 chr16:33964783 MIR1826 0.5 6.63 0.38 1.93e-10 Fibrinogen levels; CESC cis rs3768617 0.528 rs10911240 chr1:183062948 T/C ch.1.3577855R chr1:183094577 LAMC1 0.88 14.24 0.66 1.45e-34 Fuchs's corneal dystrophy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21232937 chr17:56408691 MIR142 -0.42 -6.8 -0.39 6.72e-11 Gut microbiota (bacterial taxa); CESC cis rs1163251 0.837 rs2764886 chr1:120241771 C/T cg19096424 chr1:120255104 PHGDH 0.52 6.67 0.38 1.52e-10 Blood metabolite levels; CESC cis rs539096 0.566 rs3011220 chr1:44308867 A/G cg23954153 chr1:44402353 ARTN -0.34 -5.28 -0.31 2.65e-7 Intelligence (multi-trait analysis); CESC cis rs12134245 0.755 rs11164928 chr1:92012678 G/A cg02896835 chr1:92012615 NA -0.56 -7.68 -0.43 3.1400000000000003e-13 Breast cancer; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg18992706 chr13:44453352 CCDC122;C13orf31 -0.42 -6.22 -0.36 1.98e-9 Breast cancer; CESC cis rs2463822 0.687 rs118012228 chr11:62155914 G/A cg06239285 chr11:62104954 ASRGL1 -1.05 -8.98 -0.48 5.35e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs7617480 0.648 rs9848268 chr3:48762271 C/T cg07636037 chr3:49044803 WDR6 0.79 10.38 0.54 2.14e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs11686934 0.780 rs6731423 chr2:70173327 A/C cg02498382 chr2:70120550 SNRNP27 -0.3 -5.18 -0.3 4.32e-7 High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08929390 chr7:10979341 NDUFA4 -0.58 -6.99 -0.39 2.24e-11 Gut microbiome composition (summer); CESC cis rs72781680 0.898 rs55657921 chr2:24008091 C/G cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.71 -9.85 -0.52 1.04e-19 Prudent dietary pattern; CESC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg18099408 chr3:52552593 STAB1 -0.34 -5.83 -0.34 1.61e-8 Electroencephalogram traits; CESC cis rs3796352 1.000 rs3806692 chr3:53080987 C/G cg07884673 chr3:53033167 SFMBT1 0.59 5.29 0.31 2.58e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg00033643 chr7:134001901 SLC35B4 0.4 5.12 0.3 5.93e-7 Mean platelet volume; CESC cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg19077165 chr18:44547161 KATNAL2 0.54 7.78 0.43 1.59e-13 Personality dimensions; CESC cis rs7927771 0.524 rs7942074 chr11:47720509 T/C cg20307385 chr11:47447363 PSMC3 0.61 8.56 0.47 9.2e-16 Subjective well-being; CESC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg24829409 chr8:58192753 C8orf71 -0.75 -9.78 -0.52 1.72e-19 Developmental language disorder (linguistic errors); CESC cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg26408565 chr15:76604113 ETFA -0.43 -6.25 -0.36 1.67e-9 Blood metabolite levels; CESC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg05368731 chr17:41323189 NBR1 0.76 10.35 0.54 2.73e-21 Menopause (age at onset); CESC cis rs7208859 0.673 rs11656462 chr17:29160700 G/A cg19761014 chr17:28927070 LRRC37B2 0.63 5.28 0.31 2.72e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.9 -0.56 4.33e-23 Alzheimer's disease; CESC trans rs61931739 0.500 rs11053193 chr12:34438838 G/T cg13010199 chr12:38710504 ALG10B 0.49 6.34 0.36 9.81e-10 Morning vs. evening chronotype; CESC cis rs13385 0.769 rs7737342 chr5:139611011 A/T cg26211634 chr5:139558579 C5orf32 0.47 5.19 0.3 4.23e-7 Atrial fibrillation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22349489 chr6:27114943 HIST1H2BK;HIST1H2AH 0.45 6.34 0.36 9.97e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00997411 chr1:205290916 NUAK2 -0.45 -6.23 -0.36 1.86e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11672159 chr11:77531853 C11orf67;RSF1 -0.49 -6.42 -0.37 6.2e-10 Asthma; CESC cis rs2276314 0.857 rs9304155 chr18:33585710 A/C cg05985134 chr18:33552581 C18orf21 0.62 7.46 0.42 1.21e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs250677 0.916 rs17109279 chr5:148416581 A/G cg18129178 chr5:148520854 ABLIM3 -0.52 -5.78 -0.33 2.05e-8 Breast cancer; CESC cis rs7914558 0.966 rs11191518 chr10:104782853 C/G cg04362960 chr10:104952993 NT5C2 0.43 5.74 0.33 2.59e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1949733 0.917 rs10461079 chr4:8392724 G/A cg11789530 chr4:8429930 ACOX3 -0.78 -10.65 -0.55 2.74e-22 Response to antineoplastic agents; CESC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg02018176 chr4:1364513 KIAA1530 0.62 7.97 0.44 4.61e-14 Longevity; CESC cis rs1559088 0.576 rs4805852 chr19:33609441 C/T cg27124370 chr19:33622961 WDR88 0.53 7.53 0.42 7.97e-13 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9487051 0.768 rs437779 chr6:109527691 T/G cg01475377 chr6:109611718 NA -0.44 -6.65 -0.38 1.71e-10 Reticulocyte fraction of red cells; CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.46 7.23 0.41 5.1e-12 Bipolar disorder; CESC cis rs2204008 0.775 rs11514369 chr12:38305411 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Bladder cancer; CESC cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg24818145 chr4:99064322 C4orf37 0.4 5.15 0.3 5.03e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.598 rs11855999 chr15:76627333 A/C cg00316803 chr15:76480434 C15orf27 0.45 6.14 0.35 2.94e-9 Blood metabolite levels; CESC cis rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg25427524 chr10:38739819 LOC399744 -0.62 -9.04 -0.49 3.33e-17 Extrinsic epigenetic age acceleration; CESC cis rs3820068 0.581 rs72645893 chr1:15930943 C/G cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs5769765 0.817 rs9616212 chr22:50317687 G/A cg26441486 chr22:50317300 CRELD2 0.48 5.75 0.33 2.44e-8 Schizophrenia; CESC cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg21395723 chr22:39101663 GTPBP1 0.43 5.31 0.31 2.32e-7 Menopause (age at onset); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg24485284 chr11:30358536 C11orf46 0.37 6.3 0.36 1.26e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2034088 0.833 rs7219151 chr17:440497 G/A cg06217071 chr17:408420 NA 0.49 9.43 0.5 2.12e-18 Hip circumference adjusted for BMI; CESC cis rs730775 0.505 rs324137 chr6:44273546 G/T cg21130236 chr6:44246755 TMEM151B 0.26 5.27 0.31 2.83e-7 Monocyte percentage of white cells;Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02928052 chr19:34988812 WTIP -0.56 -6.63 -0.38 1.86e-10 Gut microbiome composition (summer); CESC cis rs754466 0.512 rs67607593 chr10:79649050 A/G cg17075019 chr10:79541650 NA -0.83 -12.1 -0.6 4.06e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs727563 0.594 rs5758408 chr22:42077737 A/C cg17376030 chr22:41985996 PMM1 -0.79 -8.55 -0.47 9.65e-16 Crohn's disease;Inflammatory bowel disease; CESC cis rs9300255 0.596 rs10773002 chr12:123746961 A/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.33 5.04 0.3 8.72e-7 Neutrophil percentage of white cells; CESC cis rs2839186 0.934 rs17176520 chr21:47682081 T/C cg12516959 chr21:47718080 NA -0.35 -5.16 -0.3 4.83e-7 Testicular germ cell tumor; CESC cis rs9790314 0.967 rs463928 chr3:161087734 A/T cg04691961 chr3:161091175 C3orf57 -0.4 -5.15 -0.3 5.06e-7 Morning vs. evening chronotype; CESC cis rs7799006 0.593 rs12531150 chr7:2289888 C/T cg08027265 chr7:2291960 NA -0.56 -9.7 -0.51 2.99e-19 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs35146811 0.700 rs2950520 chr7:99827148 T/C cg13215871 chr17:75784724 NA -0.34 -6.33 -0.36 1.07e-9 Coronary artery disease; CESC cis rs9905704 0.647 rs2036730 chr17:57038282 A/G cg12560992 chr17:57184187 TRIM37 0.62 7.82 0.43 1.22e-13 Testicular germ cell tumor; CESC cis rs9322193 0.962 rs62439843 chr6:149997657 T/C cg07701084 chr6:150067640 NUP43 0.41 5.56 0.32 6.68e-8 Lung cancer; CESC cis rs7091068 0.616 rs1890657 chr10:95506087 G/A cg20715218 chr10:95462985 C10orf4 0.57 5.37 0.31 1.71e-7 Urinary tract infection frequency; CESC cis rs941873 0.805 rs8837 chr10:81114813 C/G cg11057378 chr10:81107060 PPIF 0.36 5.7 0.33 3.22e-8 Height; CESC cis rs9399137 0.507 rs13197750 chr6:135312380 G/A cg22676075 chr6:135203613 NA 0.53 7.09 0.4 1.22e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs16854884 0.802 rs6783329 chr3:143798454 T/G cg06585982 chr3:143692056 C3orf58 0.44 5.58 0.32 6.09e-8 Economic and political preferences (feminism/equality); CESC cis rs1008375 1.000 rs1121089 chr4:17676476 C/A cg02297831 chr4:17616191 MED28 0.45 5.64 0.33 4.42e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9915657 0.870 rs12600458 chr17:70130545 C/T cg09344028 chr17:70110421 NA 0.34 6.08 0.35 4.26e-9 Thyroid hormone levels; CESC cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.76 7.05 0.4 1.57e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4835473 0.932 rs17695782 chr4:144751464 A/G cg25736465 chr4:144833511 NA -0.45 -6.75 -0.38 9.22e-11 Immature fraction of reticulocytes; CESC cis rs3820928 0.874 rs6707265 chr2:227849255 T/A cg05526886 chr2:227700861 RHBDD1 -0.42 -5.12 -0.3 5.89e-7 Pulmonary function; CESC cis rs4455778 0.536 rs38771 chr7:48940564 C/A cg26309511 chr7:48887640 NA 0.35 5.11 0.3 6.1e-7 Lung cancer in never smokers; CESC cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg12386194 chr3:101231763 SENP7 0.57 6.08 0.35 4.12e-9 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg08859206 chr1:53392774 SCP2 -0.6 -8.11 -0.45 1.95e-14 Monocyte count; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg19752117 chr17:4850710 PFN1 0.6 6.37 0.36 8.28e-10 Diastolic blood pressure; CESC cis rs941873 0.868 rs2145998 chr10:81121696 T/A cg09469691 chr10:81107165 PPIF 0.55 7.62 0.42 4.4e-13 Height; CESC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.38 -6.1 -0.35 3.77e-9 Cystic fibrosis severity; CESC cis rs4925386 0.625 rs3810550 chr20:60912117 C/T cg22307297 chr20:60903441 LAMA5 0.39 5.27 0.31 2.88e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg00149659 chr3:10157352 C3orf10 0.97 11.51 0.58 3.85e-25 Alzheimer's disease; CESC cis rs929354 0.772 rs2366214 chr7:156992461 A/G cg05182265 chr7:156933206 UBE3C -0.51 -7.51 -0.42 9.08e-13 Body mass index; CESC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.18 0.3 4.38e-7 Height; CESC trans rs9467711 0.606 rs2235251 chr6:26431982 C/T cg06606381 chr12:133084897 FBRSL1 -0.82 -6.98 -0.39 2.4e-11 Autism spectrum disorder or schizophrenia; CESC cis rs9486719 0.901 rs13206547 chr6:97006942 T/C cg18709589 chr6:96969512 KIAA0776 -0.52 -5.69 -0.33 3.43e-8 Migraine;Coronary artery disease; CESC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg11890956 chr21:40555474 PSMG1 -0.67 -9.54 -0.51 1e-18 Menarche (age at onset); CESC cis rs4253772 0.513 rs9306512 chr22:46716603 T/C cg24881330 chr22:46731750 TRMU 0.94 10.78 0.55 1.06e-22 LDL cholesterol;Cholesterol, total; CESC cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg05234568 chr11:5960015 NA -0.55 -6.41 -0.37 6.48e-10 DNA methylation (variation); CESC cis rs7680126 0.633 rs11727390 chr4:10296760 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -6.0 -0.35 6.44e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs6582630 0.555 rs1969362 chr12:38514843 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.65 0.55 2.78e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs6087990 0.735 rs4911260 chr20:31376490 T/C cg13636640 chr20:31349939 DNMT3B 0.81 13.12 0.63 1.18e-30 Ulcerative colitis; CESC cis rs501120 1.000 rs620356 chr10:44761073 A/C cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.1e-11 Coronary artery disease;Coronary heart disease; CESC cis rs7819412 0.775 rs2898257 chr8:10935368 A/C cg21775007 chr8:11205619 TDH -0.37 -5.06 -0.3 7.87e-7 Triglycerides; CESC cis rs75477785 0.590 rs72649955 chr1:210304209 A/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.77 5.34 0.31 2.03e-7 Cleft lip with or without cleft palate; CESC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg02592271 chr2:27665507 KRTCAP3 -0.3 -6.0 -0.35 6.61e-9 Total body bone mineral density; CESC cis rs7100689 0.577 rs10749550 chr10:82031197 A/G cg09936400 chr10:82049201 MAT1A 0.39 5.66 0.33 3.94e-8 Post bronchodilator FEV1; CESC cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg07636037 chr3:49044803 WDR6 1.08 19.57 0.77 2.17e-53 Parkinson's disease; CESC cis rs3741404 1.000 rs3741404 chr11:63999240 G/C cg04317338 chr11:64019027 PLCB3 0.6 7.34 0.41 2.58e-12 Platelet count; CESC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg04166393 chr7:2884313 GNA12 0.62 7.92 0.44 6.73e-14 Height; CESC cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg26116260 chr4:7069785 GRPEL1 -0.87 -9.0 -0.48 4.52e-17 Monocyte percentage of white cells; CESC cis rs10751667 0.961 rs7395928 chr11:952605 T/G cg01483505 chr11:975446 AP2A2 0.39 5.25 0.31 3.18e-7 Alzheimer's disease (late onset); CESC cis rs4969178 1.000 rs7212201 chr17:76393896 C/A cg05887092 chr17:76393375 PGS1 0.59 9.26 0.49 7.46e-18 HDL cholesterol levels; CESC cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg11366901 chr6:160182831 ACAT2 0.8 10.23 0.53 6.37e-21 Age-related macular degeneration (geographic atrophy); CESC trans rs35110281 0.777 rs7276215 chr21:44990697 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 7.51 0.42 8.97e-13 Mean corpuscular volume; CESC cis rs4319547 0.619 rs7973869 chr12:122874284 G/C cg05707623 chr12:122985044 ZCCHC8 -0.51 -5.82 -0.34 1.68e-8 Body mass index; CESC cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg16339924 chr4:17578868 LAP3 0.59 7.28 0.41 3.74e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg03388025 chr16:89894329 SPIRE2 0.39 7.41 0.41 1.74e-12 Vitiligo; CESC cis rs854765 0.533 rs2955354 chr17:17948716 G/C cg09796270 chr17:17721594 SREBF1 -0.38 -5.07 -0.3 7.66e-7 Total body bone mineral density; CESC trans rs8017423 1.000 rs8015379 chr14:90679432 C/T cg01911440 chr17:78818045 RPTOR -0.4 -6.03 -0.35 5.43e-9 Mortality in heart failure; CESC cis rs67311347 1.000 rs2305521 chr3:40429183 A/G cg24209194 chr3:40518798 ZNF619 0.47 6.0 0.35 6.55e-9 Renal cell carcinoma; CESC cis rs1801251 1.000 rs7558609 chr2:233700379 C/T cg08000102 chr2:233561755 GIGYF2 0.67 9.54 0.51 9.96e-19 Coronary artery disease; CESC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg03806693 chr22:41940476 POLR3H -1.12 -13.98 -0.65 1.23e-33 Vitiligo; CESC trans rs2727020 0.523 rs4115783 chr11:49556026 G/A cg15704280 chr7:45808275 SEPT13 0.86 10.72 0.55 1.6e-22 Coronary artery disease; CESC cis rs7103648 0.695 rs7933019 chr11:47509137 G/C cg20307385 chr11:47447363 PSMC3 0.83 12.3 0.6 8.59e-28 Diastolic blood pressure;Systolic blood pressure; CESC cis rs7264396 0.790 rs2425125 chr20:34330954 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.84 11.47 0.58 5.47e-25 Total cholesterol levels; CESC cis rs6963495 0.818 rs73190166 chr7:105159955 G/A cg13798780 chr7:105162888 PUS7 0.76 7.69 0.43 2.93e-13 Bipolar disorder (body mass index interaction); CESC cis rs4720575 1.000 rs6463383 chr7:47091686 A/G cg00036614 chr7:47093842 NA 0.42 6.65 0.38 1.63e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs12477438 0.520 rs13023744 chr2:99738224 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.18 0.68 6.85e-38 Chronic sinus infection; CESC cis rs72781680 0.846 rs72780198 chr2:24014883 T/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs12477438 0.605 rs4585080 chr2:99557327 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.63 -8.47 -0.46 1.69e-15 Chronic sinus infection; CESC cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.44 7.24 0.41 4.8e-12 Personality dimensions; CESC cis rs3749237 0.595 rs35701831 chr3:49515000 A/C cg03060546 chr3:49711283 APEH 0.78 11.83 0.59 3.2e-26 Resting heart rate; CESC cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg22875332 chr1:76189707 ACADM -0.65 -7.69 -0.43 2.95e-13 Blood metabolite levels;Acylcarnitine levels; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg11072298 chr12:113772666 SLC24A6 -0.47 -6.09 -0.35 3.97e-9 Recombination measurement; CESC cis rs4604732 0.685 rs4925673 chr1:247636800 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.4 0.32 1.45e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs977987 0.872 rs4243111 chr16:75320827 C/T cg03315344 chr16:75512273 CHST6 0.39 5.63 0.33 4.57e-8 Dupuytren's disease; CESC cis rs6681460 0.932 rs2044400 chr1:67054081 T/A cg02459107 chr1:67143332 SGIP1 0.36 5.08 0.3 7.08e-7 Presence of antiphospholipid antibodies; CESC cis rs3739821 1.000 rs3739821 chr9:130702477 A/G cg09665592 chr9:130699885 DPM2 -0.51 -5.33 -0.31 2.13e-7 Glaucoma (primary angle closure); CESC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Lung function (FEV1); CESC cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg20307385 chr11:47447363 PSMC3 -0.57 -6.82 -0.39 6.24e-11 Subjective well-being; CESC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.7 0.33 3.2e-8 Electroencephalogram traits; CESC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg04369109 chr6:150039330 LATS1 -0.44 -6.38 -0.36 7.99e-10 Lung cancer; CESC cis rs2710642 0.611 rs2204656 chr2:62883868 C/T cg17519650 chr2:63277830 OTX1 -0.44 -5.28 -0.31 2.63e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs9611565 0.729 rs2413646 chr22:41906325 C/T cg17376030 chr22:41985996 PMM1 0.76 8.18 0.45 1.22e-14 Vitiligo; CESC cis rs10876993 0.715 rs2169987 chr12:58012111 G/A cg18357645 chr12:58087776 OS9 -0.55 -8.32 -0.45 4.8e-15 Celiac disease or Rheumatoid arthritis; CESC trans rs17181170 0.553 rs4858949 chr3:87175728 C/G ch.2.199792288R chr2:200084043 NA -0.44 -6.04 -0.35 5.3300000000000004e-09 Prostate cancer; CESC cis rs9303401 0.614 rs3887355 chr17:56538639 T/C cg12560992 chr17:57184187 TRIM37 0.51 5.08 0.3 7.08e-7 Cognitive test performance; CESC cis rs6502050 0.761 rs7225637 chr17:80059758 A/G cg23985595 chr17:80112537 CCDC57 -0.38 -5.52 -0.32 8.11e-8 Life satisfaction; CESC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg18876405 chr7:65276391 NA -0.48 -6.49 -0.37 4.22e-10 Calcium levels; CESC cis rs7193541 0.662 rs8052367 chr16:74658867 G/A cg05580060 chr16:74700937 RFWD3 -0.43 -5.53 -0.32 7.64e-8 Multiple myeloma; CESC cis rs7216064 1.000 rs62085993 chr17:65923152 T/C cg12091567 chr17:66097778 LOC651250 -0.71 -7.28 -0.41 3.82e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1023500 0.552 rs133368 chr22:42463689 T/C cg05082376 chr22:42548792 NA -0.37 -5.06 -0.3 7.78e-7 Schizophrenia; CESC cis rs7537052 0.564 rs6669395 chr1:36653717 A/G cg24686825 chr1:36642396 MAP7D1 -0.59 -8.79 -0.47 1.99e-16 Schizophrenia; CESC cis rs7312933 0.618 rs7315968 chr12:42637086 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 6.11 0.35 3.53e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7927592 0.913 rs6591346 chr11:68384618 T/A cg16797656 chr11:68205561 LRP5 0.41 6.02 0.35 5.69e-9 Total body bone mineral density; CESC cis rs1670533 0.932 rs13140341 chr4:1054235 T/C cg04106633 chr4:1044584 NA 0.41 5.25 0.31 3.17e-7 Recombination rate (females); CESC cis rs6598955 0.724 rs7547520 chr1:26592310 C/T cg04990556 chr1:26633338 UBXN11 -0.78 -11.08 -0.56 1.05e-23 Obesity-related traits; CESC trans rs7760535 0.656 rs7766190 chr6:111905066 A/G cg18003189 chr10:30723096 MAP3K8 -0.4 -6.21 -0.36 2e-9 Metabolic traits; CESC cis rs72901758 0.739 rs72901754 chr17:76244398 G/A cg23302638 chr17:76210176 BIRC5 0.5 5.45 0.32 1.13e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs36051895 0.623 rs1575283 chr9:5238588 C/T cg02405213 chr9:5042618 JAK2 -0.56 -6.77 -0.38 8.35e-11 Pediatric autoimmune diseases; CESC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg13647721 chr17:30228624 UTP6 -0.62 -5.84 -0.34 1.5e-8 Hip circumference adjusted for BMI; CESC cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.89 -0.39 4.05e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.58 0.47 8.16e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9790314 1.000 rs4597724 chr3:160963110 A/G cg03342759 chr3:160939853 NMD3 -0.44 -5.77 -0.33 2.17e-8 Morning vs. evening chronotype; CESC cis rs3820928 0.874 rs4234063 chr2:227828335 A/T cg05526886 chr2:227700861 RHBDD1 0.4 5.09 0.3 6.84e-7 Pulmonary function; CESC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg23172400 chr8:95962367 TP53INP1 -0.44 -9.04 -0.49 3.45e-17 Type 2 diabetes; CESC cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.93 0.34 9.3e-9 Tonsillectomy; CESC cis rs2414059 0.518 rs2289108 chr15:50782335 G/A cg08437265 chr15:50716283 USP8 -0.46 -5.89 -0.34 1.18e-8 QT interval; CESC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg23161317 chr6:28129485 ZNF389 0.47 5.89 0.34 1.18e-8 Depression; CESC cis rs11871801 0.750 rs7216927 chr17:40651497 T/A cg21433558 chr17:40837037 CNTNAP1 0.45 5.34 0.31 2.03e-7 Crohn's disease; CESC cis rs1559088 0.948 rs12610266 chr19:33581237 C/G cg17764715 chr19:33622953 WDR88 -0.52 -6.9 -0.39 3.8e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg07507251 chr3:52567010 NT5DC2 -0.34 -5.59 -0.32 5.78e-8 Bipolar disorder; CESC cis rs6032067 0.538 rs13042667 chr20:43739664 C/T cg10761708 chr20:43804764 PI3 0.45 5.11 0.3 6.08e-7 Blood protein levels; CESC cis rs12936587 0.538 rs1869771 chr17:17561094 C/A cg04398451 chr17:18023971 MYO15A 0.42 5.35 0.31 1.95e-7 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14546197 chr17:38137043 PSMD3 0.59 6.94 0.39 2.99e-11 Gut microbiome composition (summer); CESC trans rs877282 0.898 rs12358966 chr10:758703 A/G cg22713356 chr15:30763199 NA 1.08 10.52 0.54 7.14e-22 Uric acid levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21676273 chr3:45635931 LIMD1 0.47 6.11 0.35 3.56e-9 Gut microbiota (bacterial taxa); CESC cis rs5758659 0.714 rs6002626 chr22:42517989 C/G cg00645731 chr22:42541494 CYP2D7P1 0.33 5.62 0.33 4.75e-8 Cognitive function; CESC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.17 0.4 7.53e-12 Bipolar disorder; CESC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.71e-16 Initial pursuit acceleration; CESC cis rs1348850 0.645 rs4893963 chr2:178430747 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.56 -5.99 -0.35 6.95e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6138458 1.000 rs227651 chr20:24929834 A/G cg06937882 chr20:24974362 C20orf3 -0.35 -5.11 -0.3 6.15e-7 Blood protein levels; CESC cis rs4790333 0.653 rs2447103 chr17:2262997 A/C cg02569219 chr17:2266849 SGSM2 0.45 6.22 0.36 1.93e-9 Proinsulin levels; CESC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg04025307 chr7:1156635 C7orf50 0.45 5.12 0.3 5.99e-7 Bronchopulmonary dysplasia; CESC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg27572855 chr1:25598939 RHD 0.46 7.86 0.43 9.53e-14 Erythrocyte sedimentation rate; CESC cis rs9913156 0.793 rs11568061 chr17:4546445 G/A cg19197139 chr17:4613644 ARRB2 0.92 10.05 0.53 2.34e-20 Lymphocyte counts; CESC cis rs10089 0.951 rs1864923 chr5:127420843 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.48 0.54 9.74e-22 Ileal carcinoids; CESC cis rs10540 1.000 rs10540 chr11:494662 G/A cg03934478 chr11:495069 RNH1 0.56 5.36 0.31 1.77e-7 Body mass index; CESC cis rs6723226 0.803 rs387780 chr2:32502495 T/C cg02381751 chr2:32503542 YIPF4 0.9 12.67 0.61 4.51e-29 Intelligence (multi-trait analysis); CESC cis rs5769765 1.000 rs2092982 chr22:50282204 C/A cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08386897 chr10:134073820 STK32C 0.44 6.36 0.36 8.99e-10 Fibrinogen levels; CESC cis rs2204008 0.805 rs11169513 chr12:37988640 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.69 0.38 1.33e-10 Bladder cancer; CESC cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg00701064 chr4:6280414 WFS1 0.71 12.57 0.61 9.71e-29 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4253772 0.591 rs6008538 chr22:46685963 G/A cg24881330 chr22:46731750 TRMU 0.95 10.25 0.53 5.51e-21 LDL cholesterol;Cholesterol, total; CESC cis rs4460629 0.742 rs11264312 chr1:155075888 T/C cg01019262 chr1:155095195 NA -0.3 -5.05 -0.3 8.42e-7 Serum magnesium levels; CESC cis rs2243480 0.711 rs1626926 chr7:65435792 C/T cg18252515 chr7:66147081 NA -1.08 -10.48 -0.54 9.71e-22 Diabetic kidney disease; CESC cis rs2832077 0.506 rs10222093 chr21:30163518 T/C cg08807101 chr21:30365312 RNF160 -0.46 -5.15 -0.3 5.11e-7 Cognitive test performance; CESC trans rs5756813 0.754 rs4820308 chr22:38176216 G/A cg19894588 chr14:64061835 NA -0.68 -8.83 -0.48 1.45e-16 Optic cup area;Vertical cup-disc ratio; CESC cis rs7772486 0.790 rs9376968 chr6:146180364 T/C cg05347473 chr6:146136440 FBXO30 0.56 7.28 0.41 3.8e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9921222 0.565 rs10903014 chr16:377623 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 0.43 6.79 0.39 7.2e-11 Bone mineral density (spine);Bone mineral density; CESC cis rs807669 0.770 rs807458 chr22:19220648 G/T cg02655711 chr22:19163373 SLC25A1 0.37 5.34 0.31 1.99e-7 Metabolite levels; CESC cis rs11630290 0.592 rs1039817 chr15:64155367 T/A cg12036633 chr15:63758958 NA 0.45 5.44 0.32 1.21e-7 Iris characteristics; CESC trans rs2270927 1.000 rs13174383 chr5:75580416 T/G cg13563193 chr19:33072644 PDCD5 0.76 6.21 0.36 2.04e-9 Mean corpuscular volume; CESC cis rs2074585 0.517 rs11638010 chr15:91079920 A/G cg10434728 chr15:90938212 IQGAP1 -0.32 -5.23 -0.31 3.42e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg24399712 chr22:39784796 NA -0.86 -11.91 -0.59 1.8e-26 Intelligence (multi-trait analysis); CESC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg14893161 chr1:205819251 PM20D1 0.51 7.71 0.43 2.61e-13 Menarche (age at onset); CESC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg04025307 chr7:1156635 C7orf50 0.45 7.28 0.41 3.73e-12 Longevity;Endometriosis; CESC cis rs116095464 0.850 rs6896163 chr5:303686 A/G cg10591111 chr5:226296 SDHA -0.63 -5.9 -0.34 1.13e-8 Breast cancer; CESC cis rs55728055 0.661 rs62237843 chr22:32026946 C/G cg01338084 chr22:32026380 PISD 1.26 8.23 0.45 8.62e-15 Age-related hearing impairment; CESC cis rs7592578 0.766 rs62181052 chr2:191387858 A/G cg27211696 chr2:191398769 TMEM194B -0.62 -5.32 -0.31 2.26e-7 Diastolic blood pressure; CESC cis rs10911232 0.507 rs7515822 chr1:183037803 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 13.23 0.63 5.11e-31 Hypertriglyceridemia; CESC cis rs6545883 0.894 rs4672431 chr2:61519922 C/A cg15711740 chr2:61764176 XPO1 0.39 5.11 0.3 6.04e-7 Tuberculosis; CESC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10949834 1.000 rs34346732 chr7:73485813 G/A cg07137043 chr7:73588983 EIF4H -0.62 -5.08 -0.3 7.24e-7 Verbal memory performance (residualized delayed recall change); CESC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.25 0.53 5.71e-21 Prudent dietary pattern; CESC cis rs8060686 0.621 rs35432211 chr16:68095449 T/C cg26727032 chr16:67993705 SLC12A4 -0.55 -6.15 -0.35 2.9e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs1215050 0.791 rs13107606 chr4:98823187 C/A cg05340658 chr4:99064831 C4orf37 0.51 6.63 0.38 1.87e-10 Waist-to-hip ratio adjusted for body mass index; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg10578696 chr1:65532742 NA -0.49 -6.54 -0.37 3.13e-10 Thyroid stimulating hormone; CESC cis rs6912958 0.712 rs2307379 chr6:88366771 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -5.34 -0.31 1.96e-7 Monocyte percentage of white cells; CESC cis rs17818399 0.547 rs13020299 chr2:46758717 A/G cg02822958 chr2:46747628 ATP6V1E2 0.44 5.34 0.31 1.97e-7 Height; CESC cis rs2991971 0.776 rs12139364 chr1:45890155 T/C cg05343316 chr1:45956843 TESK2 -0.59 -8.39 -0.46 3.01e-15 High light scatter reticulocyte count; CESC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.43 0.37 6.06e-10 Bipolar disorder; CESC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg27266027 chr21:40555129 PSMG1 0.47 5.62 0.33 4.79e-8 Cognitive function; CESC cis rs4481887 0.893 rs28579823 chr1:248506881 C/T cg00666640 chr1:248458726 OR2T12 0.35 6.04 0.35 5.14e-9 Common traits (Other); CESC cis rs77106637 0.556 rs7123876 chr11:72444583 T/C cg04827223 chr11:72435913 ARAP1 -0.72 -11.63 -0.58 1.57e-25 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07927839 chr12:53491483 IGFBP6 0.53 6.97 0.39 2.45e-11 Gut microbiota (bacterial taxa); CESC cis rs757110 0.868 rs5219 chr11:17409572 T/C cg15432903 chr11:17409602 KCNJ11 0.67 9.58 0.51 7.26e-19 Type 2 diabetes; CESC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.51 -0.37 3.7e-10 Bipolar disorder; CESC cis rs7824557 0.707 rs3808518 chr8:11143272 A/C cg21775007 chr8:11205619 TDH -0.49 -7.12 -0.4 1.02e-11 Retinal vascular caliber; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14794786 chr7:150815320 AGAP3 0.44 6.0 0.35 6.41e-9 Fibrinogen levels; CESC cis rs4692589 1.000 rs4692784 chr4:170938581 A/G cg19918862 chr4:170955249 NA 0.35 5.49 0.32 9.23e-8 Anxiety disorder; CESC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg09509183 chr1:209979624 IRF6 0.52 5.68 0.33 3.51e-8 Cleft lip with or without cleft palate; CESC trans rs17508449 0.865 rs4838993 chr1:114135133 C/T cg23028848 chr11:57092561 TNKS1BP1 -0.76 -6.0 -0.35 6.46e-9 Leprosy; CESC cis rs62005083 1.000 rs12147975 chr14:74642792 A/G cg05179529 chr14:74551516 LIN52;ALDH6A1 0.71 5.52 0.32 7.97e-8 Mean corpuscular volume; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg01897796 chr15:59225903 SLTM -0.44 -6.2 -0.36 2.2e-9 Asthma; CESC cis rs938554 0.736 rs13125646 chr4:9982330 A/G cg00071950 chr4:10020882 SLC2A9 0.48 5.69 0.33 3.33e-8 Blood metabolite levels; CESC cis rs864537 0.622 rs2949661 chr1:167424924 C/T cg22356347 chr1:167427500 CD247 -0.4 -8.13 -0.45 1.64e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs9549260 0.755 rs2151785 chr13:41243660 G/A cg21288729 chr13:41239152 FOXO1 0.68 8.53 0.46 1.15e-15 Red blood cell count; CESC cis rs5769765 0.865 rs9616369 chr22:50304591 A/C cg02269571 chr22:50332266 NA -0.5 -6.52 -0.37 3.52e-10 Schizophrenia; CESC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg25767906 chr1:53392781 SCP2 -0.44 -5.61 -0.33 4.98e-8 Monocyte count; CESC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.08e-9 Aortic root size; CESC cis rs10189230 0.967 rs11692482 chr2:222352405 C/T cg14652038 chr2:222343519 EPHA4 0.37 7.73 0.43 2.26e-13 Urate levels in lean individuals; CESC cis rs1215050 0.740 rs13134479 chr4:99067723 G/A cg05340658 chr4:99064831 C4orf37 0.57 7.49 0.42 1.04e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.64 5.44 0.32 1.21e-7 Depression; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09381484 chr1:161147450 B4GALT3 0.46 6.04 0.35 5.15e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6674176 0.660 rs11210936 chr1:44391438 A/T cg13606994 chr1:44402422 ARTN -0.41 -6.27 -0.36 1.44e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6460942 1.000 rs17191008 chr7:12417690 T/G cg20607287 chr7:12443886 VWDE -0.8 -9.11 -0.49 2.07e-17 Coronary artery disease; CESC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg23422044 chr7:1970798 MAD1L1 0.41 5.56 0.32 6.71e-8 Bipolar disorder and schizophrenia; CESC cis rs7712401 0.601 rs246285 chr5:122244968 C/G cg19412675 chr5:122181750 SNX24 -0.4 -5.04 -0.3 8.63e-7 Mean platelet volume; CESC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg06634786 chr22:41940651 POLR3H -0.65 -6.68 -0.38 1.44e-10 Vitiligo; CESC cis rs6540559 0.673 rs17317411 chr1:209961314 C/T cg23283495 chr1:209979779 IRF6 -0.46 -5.04 -0.3 8.69e-7 Cleft lip with or without cleft palate; CESC cis rs34779708 0.966 rs2045917 chr10:35418526 G/A cg04310649 chr10:35416472 CREM -0.54 -6.56 -0.37 2.73e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17091266 chr1:1850736 TMEM52 -0.53 -6.13 -0.35 3.17e-9 Gut microbiome composition (summer); CESC cis rs6695640 0.854 rs2800699 chr1:17733136 C/T cg01904812 chr1:17746340 RCC2 0.35 5.17 0.3 4.64e-7 Mean platelet volume; CESC cis rs1728785 1.000 rs11647432 chr16:68565426 C/T cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC trans rs60843830 1.000 rs4497901 chr2:239969 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 8.04 0.44 2.96e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.76 0.65 7.11e-33 Prudent dietary pattern; CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg06877462 chr1:205807181 PM20D1 0.43 6.48 0.37 4.5e-10 Menarche (age at onset); CESC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -6.78 -0.38 7.61e-11 Bipolar disorder; CESC cis rs909674 0.690 rs5750823 chr22:39829973 C/T cg11247378 chr22:39784982 NA -0.55 -8.24 -0.45 8.23e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg23048001 chr7:2026167 MAD1L1 0.47 6.13 0.35 3.22e-9 Bipolar disorder and schizophrenia; CESC cis rs1448094 0.791 rs7303256 chr12:86333217 C/T cg02569458 chr12:86230093 RASSF9 -0.41 -5.83 -0.34 1.65e-8 Major depressive disorder; CESC cis rs7267979 0.933 rs2424708 chr20:25281398 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.84 16.13 0.7 3.07e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs7772486 0.754 rs6922507 chr6:146250155 A/T cg05347473 chr6:146136440 FBXO30 -0.57 -7.26 -0.41 4.32e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg24690094 chr11:67383802 NA 0.38 6.26 0.36 1.51e-9 Mean corpuscular volume; CESC cis rs7264396 0.623 rs2425123 chr20:34329547 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.88e-22 Total cholesterol levels; CESC cis rs7914558 1.000 rs11191577 chr10:104902165 A/G cg04362960 chr10:104952993 NT5C2 0.46 5.9 0.34 1.08e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08281556 chr6:105628013 POPDC3 0.6 6.72 0.38 1.14e-10 Gut microbiome composition (summer); CESC cis rs11581903 0.568 rs11590859 chr1:53073838 G/T cg19751897 chr1:52520827 TXNDC12;BTF3L4 0.73 5.47 0.32 1.06e-7 Joint mobility (Beighton score); CESC cis rs4664308 0.692 rs10497213 chr2:160963603 G/A cg03641300 chr2:160917029 PLA2R1 -0.44 -6.23 -0.36 1.86e-9 Idiopathic membranous nephropathy; CESC cis rs4253772 0.550 rs738444 chr22:46721088 C/T cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.57 5.91 0.34 1.07e-8 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10585161 chr5:115420544 COMMD10 -0.68 -8.11 -0.45 1.88e-14 Gut microbiome composition (summer); CESC cis rs2282802 0.685 rs67813630 chr5:139623592 C/A cg26211634 chr5:139558579 C5orf32 0.48 6.95 0.39 2.78e-11 Intelligence (multi-trait analysis); CESC cis rs5769707 0.681 rs135879 chr22:50018651 C/T cg05373962 chr22:49881684 NA -0.33 -5.15 -0.3 5.18e-7 Monocyte count;Monocyte percentage of white cells; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24695950 chr2:162364264 NA -0.51 -6.43 -0.37 5.8e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg16339924 chr4:17578868 LAP3 0.66 8.45 0.46 1.95e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs36051895 0.623 rs1830610 chr9:5260079 C/T cg02405213 chr9:5042618 JAK2 -0.53 -6.55 -0.37 2.97e-10 Pediatric autoimmune diseases; CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg15147215 chr3:52552868 STAB1 -0.31 -5.7 -0.33 3.25e-8 Bipolar disorder; CESC cis rs870825 0.616 rs7660064 chr4:185617529 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs13631 0.894 rs7856589 chr9:140003921 A/G cg14289826 chr9:140003911 NA -0.37 -7.12 -0.4 1e-11 Cerebrospinal fluid biomarker levels; CESC cis rs10504229 0.679 rs72649114 chr8:58037491 G/T cg22535103 chr8:58192502 C8orf71 -0.63 -7.02 -0.4 1.86e-11 Developmental language disorder (linguistic errors); CESC cis rs3780486 0.846 rs12554995 chr9:33132044 A/G cg13443165 chr9:33130375 B4GALT1 0.45 6.46 0.37 5e-10 IgG glycosylation; CESC cis rs6942756 1.000 rs66538149 chr7:128974061 G/A cg02491457 chr7:128862824 NA -0.68 -9.08 -0.49 2.52e-17 White matter hyperintensity burden; CESC cis rs8031584 0.918 rs11639169 chr15:31255438 C/T cg08704250 chr15:31115839 NA -0.57 -7.15 -0.4 8.22e-12 Huntington's disease progression; CESC cis rs11583043 0.918 rs58029001 chr1:101393409 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.56 6.35 0.36 9.26e-10 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs9916302 0.904 rs2338798 chr17:37547269 T/C cg20243544 chr17:37824526 PNMT -0.48 -6.12 -0.35 3.41e-9 Glomerular filtration rate (creatinine); CESC cis rs7246865 0.510 rs7254154 chr19:17178119 A/C cg16202187 chr19:17186497 HAUS8;MYO9B 0.51 6.56 0.37 2.84e-10 Reticulocyte fraction of red cells; CESC cis rs4631830 0.540 rs2843562 chr10:51496796 A/G cg16070123 chr10:51489643 NA 0.33 5.13 0.3 5.71e-7 Prostate-specific antigen levels; CESC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg19163074 chr7:65112434 INTS4L2 0.45 5.57 0.32 6.16e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12457035 chr5:180688144 TRIM52 0.52 6.02 0.35 5.91e-9 Gut microbiome composition (summer); CESC cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg00677455 chr12:58241039 CTDSP2 0.51 6.57 0.37 2.6200000000000003e-10 Multiple sclerosis; CESC cis rs1499972 0.590 rs62264777 chr3:117653515 G/C cg07612923 chr3:117604196 NA 0.69 6.3 0.36 1.22e-9 Schizophrenia; CESC trans rs7726839 0.561 rs4957049 chr5:579080 C/A cg25482853 chr8:67687455 SGK3 0.88 9.47 0.5 1.62e-18 Obesity-related traits; CESC cis rs17376456 0.877 rs13169675 chr5:93331284 A/G cg25358565 chr5:93447407 FAM172A 1.12 10.33 0.54 3.07e-21 Diabetic retinopathy; CESC cis rs10463316 0.779 rs6871318 chr5:150801545 G/A cg03212797 chr5:150827313 SLC36A1 -0.5 -6.57 -0.37 2.71e-10 Metabolite levels (Pyroglutamine); CESC cis rs7107174 1.000 rs7941617 chr11:78021146 C/T cg02023728 chr11:77925099 USP35 0.39 5.6 0.33 5.42e-8 Testicular germ cell tumor; CESC cis rs78456975 1.000 rs13429866 chr2:1555211 C/A cg26248373 chr2:1572462 NA -0.58 -5.22 -0.31 3.68e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs8017423 0.967 rs7147952 chr14:90720831 G/A cg14092571 chr14:90743983 NA -0.55 -8.26 -0.45 6.87e-15 Mortality in heart failure; CESC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg13126279 chr21:47581558 C21orf56 -0.5 -6.88 -0.39 4.33e-11 Testicular germ cell tumor; CESC cis rs17818399 0.926 rs35350086 chr2:46834036 C/G cg06386533 chr2:46925753 SOCS5 0.48 5.32 0.31 2.18e-7 Height; CESC cis rs2658782 0.547 rs10765602 chr11:93048165 G/T cg15737290 chr11:93063684 CCDC67 0.52 7.24 0.41 4.88e-12 Pulmonary function decline; CESC cis rs9309473 1.000 rs2140195 chr2:73702344 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -6.75 -0.38 9.15e-11 Metabolite levels; CESC cis rs4835473 0.863 rs7696828 chr4:144621999 G/C cg25736465 chr4:144833511 NA 0.36 5.38 0.31 1.63e-7 Immature fraction of reticulocytes; CESC cis rs7772486 0.875 rs2748497 chr6:146319417 C/T cg23711669 chr6:146136114 FBXO30 0.74 10.31 0.53 3.65e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg18758796 chr5:131593413 PDLIM4 0.38 5.12 0.3 5.79e-7 Breast cancer; CESC cis rs17407555 0.779 rs6851524 chr4:10155041 C/A cg11266682 chr4:10021025 SLC2A9 -0.49 -5.66 -0.33 3.92e-8 Schizophrenia (age at onset); CESC cis rs2204008 0.777 rs8189597 chr12:38307739 G/C cg13010199 chr12:38710504 ALG10B -0.54 -6.79 -0.38 7.4e-11 Bladder cancer; CESC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg04025307 chr7:1156635 C7orf50 0.41 5.62 0.33 4.93e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs67311347 1.000 rs6801185 chr3:40505060 C/T cg09455208 chr3:40491958 NA -0.47 -8.04 -0.44 2.9e-14 Renal cell carcinoma; CESC cis rs9611565 0.729 rs137831 chr22:41903813 A/C cg06481639 chr22:41940642 POLR3H -0.47 -5.43 -0.32 1.25e-7 Vitiligo; CESC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg18252515 chr7:66147081 NA 0.4 5.21 0.3 3.78e-7 Aortic root size; CESC cis rs11785400 0.793 rs9297970 chr8:143723386 C/T cg24634471 chr8:143751801 JRK 0.46 5.82 0.34 1.73e-8 Schizophrenia; CESC cis rs546131 0.928 rs483976 chr11:34840167 C/G cg11058730 chr11:34937778 PDHX;APIP 0.48 6.02 0.35 5.66e-9 Lung disease severity in cystic fibrosis; CESC cis rs4975709 1.000 rs4975709 chr5:1877280 A/C cg15595755 chr5:1867978 NA 0.47 7.61 0.42 4.78e-13 Cardiovascular disease risk factors; CESC trans rs10489896 0.541 rs16843133 chr1:234564255 A/G cg10395685 chr11:86085715 CCDC81 0.41 6.02 0.35 5.86e-9 Cognitive test performance; CESC cis rs7914558 0.966 rs10883805 chr10:104708251 T/C cg08650961 chr10:104748594 CNNM2 0.32 5.22 0.31 3.62e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs11871801 0.517 rs645692 chr17:40701073 C/T cg21433558 chr17:40837037 CNTNAP1 0.52 6.41 0.37 6.56e-10 Crohn's disease; CESC cis rs6502050 0.835 rs3924781 chr17:80113130 T/C cg23985595 chr17:80112537 CCDC57 -0.4 -6.25 -0.36 1.64e-9 Life satisfaction; CESC cis rs7542091 0.704 rs2142907 chr1:210039505 T/C cg22029157 chr1:209979665 IRF6 0.5 7.7 0.43 2.78e-13 Monobrow; CESC cis rs1267303 0.675 rs1267312 chr1:46986748 C/G cg25110126 chr1:46999211 NA -0.72 -8.9 -0.48 8.74e-17 Monobrow; CESC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.74e-9 Prudent dietary pattern; CESC trans rs1814175 0.617 rs6486020 chr11:49769149 T/G cg15704280 chr7:45808275 SEPT13 -0.99 -17.45 -0.73 6.41e-46 Height; CESC cis rs9399135 0.967 rs7766189 chr6:135353851 A/C cg24558204 chr6:135376177 HBS1L 0.51 7.1 0.4 1.13e-11 Red blood cell count; CESC cis rs7818345 0.967 rs4481612 chr8:19285336 T/G cg11303988 chr8:19266685 CSGALNACT1 0.37 6.42 0.37 6.36e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs7100689 0.577 rs9420359 chr10:82054873 C/T cg09936400 chr10:82049201 MAT1A 0.4 6.04 0.35 5.06e-9 Post bronchodilator FEV1; CESC cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg06022373 chr22:39101656 GTPBP1 0.89 13.91 0.65 2.08e-33 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18968306 chr11:134093878 NCAPD3;VPS26B 0.62 7.3 0.41 3.41e-12 Gut microbiome composition (summer); CESC trans rs1814175 0.645 rs28445479 chr11:50047999 A/G cg03929089 chr4:120376271 NA -0.9 -14.49 -0.66 1.88e-35 Height; CESC trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.44 -0.46 2.06e-15 Intelligence (multi-trait analysis); CESC cis rs11098499 0.908 rs71614449 chr4:120387055 C/T cg09307838 chr4:120376055 NA 0.95 13.96 0.65 1.42e-33 Corneal astigmatism; CESC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs9790314 0.871 rs339114 chr3:161109220 C/T cg03342759 chr3:160939853 NMD3 0.48 6.68 0.38 1.44e-10 Morning vs. evening chronotype; CESC cis rs9291683 0.507 rs6849273 chr4:10021595 C/T cg00071950 chr4:10020882 SLC2A9 0.81 14.09 0.65 4.84e-34 Bone mineral density; CESC cis rs61776719 0.520 rs72661887 chr1:38416310 C/T cg26398791 chr1:38455867 SF3A3 -0.41 -5.28 -0.31 2.69e-7 Coronary artery disease; CESC cis rs2952156 0.920 rs732084 chr17:37834357 A/C cg07936489 chr17:37558343 FBXL20 -0.6 -7.98 -0.44 4.35e-14 Asthma; CESC cis rs4720118 0.875 rs3779239 chr7:33430271 G/A cg22798885 chr7:33102694 NT5C3 -0.37 -5.1 -0.3 6.42e-7 Leprosy; CESC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg25036284 chr2:26402008 FAM59B 0.86 9.34 0.5 4.17e-18 Gut microbiome composition (summer); CESC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg27266027 chr21:40555129 PSMG1 0.43 5.25 0.31 3.13e-7 Cognitive function; CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg16132339 chr22:24313637 DDTL;DDT 0.46 7.05 0.4 1.58e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg18404041 chr3:52824283 ITIH1 0.39 6.5 0.37 3.94e-10 Bipolar disorder; CESC cis rs7520050 0.966 rs10789475 chr1:46304177 C/G cg24296786 chr1:45957014 TESK2 0.42 5.42 0.32 1.33e-7 Red blood cell count;Reticulocyte count; CESC cis rs11098499 0.675 rs11098534 chr4:120556772 T/G cg09307838 chr4:120376055 NA 0.77 10.26 0.53 4.96e-21 Corneal astigmatism; CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg15147215 chr3:52552868 STAB1 -0.32 -5.73 -0.33 2.73e-8 Cognitive function; CESC cis rs2979489 0.624 rs62505275 chr8:30437639 C/T cg26383811 chr8:30366931 RBPMS -0.7 -7.99 -0.44 4.03e-14 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs11083475 0.607 rs6508816 chr19:39267783 G/A cg07905965 chr19:39260460 NA 0.38 5.63 0.33 4.56e-8 Heart rate; CESC cis rs965469 1.000 rs6051703 chr20:3252347 A/T cg25506879 chr20:3388711 C20orf194 -0.58 -6.24 -0.36 1.7e-9 IFN-related cytopenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09138524 chr22:19776431 GNB1L 0.46 6.18 0.35 2.45e-9 Fibrinogen levels; CESC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg05872129 chr22:39784769 NA -0.84 -11.4 -0.57 9.27e-25 Intelligence (multi-trait analysis); CESC cis rs11252926 0.604 rs12359454 chr10:568081 T/C cg16386425 chr10:429943 DIP2C 0.47 5.64 0.33 4.42e-8 Psychosis in Alzheimer's disease; CESC cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg17366294 chr4:99064904 C4orf37 0.58 8.25 0.45 7.41e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg22823121 chr1:150693482 HORMAD1 0.47 7.05 0.4 1.51e-11 Urate levels; CESC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.6 -0.42 4.99e-13 Gut microbiome composition (summer); CESC cis rs921968 0.541 rs7604319 chr2:219538799 A/C cg02176678 chr2:219576539 TTLL4 -0.57 -9.75 -0.51 2.11e-19 Mean corpuscular hemoglobin concentration; CESC cis rs7116495 0.609 rs7113436 chr11:71689599 A/T cg26138937 chr11:71823887 C11orf51 1.31 7.73 0.43 2.18e-13 Severe influenza A (H1N1) infection; CESC cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg05585544 chr11:47624801 NA 0.49 7.37 0.41 2.2e-12 Subjective well-being; CESC cis rs79349575 0.749 rs1057902 chr17:47005588 C/T cg16584676 chr17:46985605 UBE2Z 0.54 6.62 0.38 1.98e-10 Type 2 diabetes; CESC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg00166722 chr3:10149974 C3orf24 0.51 6.26 0.36 1.58e-9 Alzheimer's disease; CESC cis rs7666738 0.830 rs1426672 chr4:98923984 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg27121462 chr16:89883253 FANCA 0.75 10.53 0.54 6.74e-22 Vitiligo; CESC cis rs4803468 0.967 rs7259900 chr19:41889429 A/T cg09537434 chr19:41945824 ATP5SL -1.05 -18.71 -0.75 2.35e-50 Height; CESC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 11.96 0.59 1.2e-26 Alzheimer's disease; CESC cis rs7666738 0.712 rs11731393 chr4:98859070 G/C cg05340658 chr4:99064831 C4orf37 0.56 5.54 0.32 7.28e-8 Colonoscopy-negative controls vs population controls; CESC cis rs12681366 0.734 rs28641679 chr8:95406693 G/A cg13257157 chr8:95487014 RAD54B 0.39 5.24 0.31 3.24e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs698833 0.509 rs10198291 chr2:44539009 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 5.25 0.31 3.1e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7107174 1.000 rs2510045 chr11:77920563 G/T cg02023728 chr11:77925099 USP35 0.46 6.16 0.35 2.68e-9 Testicular germ cell tumor; CESC cis rs7084402 0.967 rs2577393 chr10:60286159 C/T cg07615347 chr10:60278583 BICC1 0.59 9.44 0.5 2.04e-18 Refractive error; CESC cis rs8005677 0.798 rs61977741 chr14:23400979 G/C cg01529538 chr14:23388837 RBM23 0.43 5.71 0.33 3.05e-8 Cognitive ability (multi-trait analysis); CESC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg18490616 chr2:88469792 THNSL2 -0.72 -10.68 -0.55 2.25e-22 Response to metformin (IC50); CESC cis rs6748734 1.000 rs4293565 chr2:241834770 A/G cg04034577 chr2:241836375 C2orf54 -0.5 -8.74 -0.47 2.65e-16 Urinary metabolites; CESC cis rs2749592 0.611 rs176888 chr10:38406161 C/A cg25427524 chr10:38739819 LOC399744 -0.63 -8.36 -0.46 3.58e-15 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs3126085 0.935 rs12738889 chr1:152257688 G/A cg03465714 chr1:152285911 FLG 0.45 5.54 0.32 7.12e-8 Atopic dermatitis; CESC cis rs6460942 0.731 rs75994414 chr7:12307992 C/A cg10578991 chr7:12443926 VWDE -0.59 -6.16 -0.35 2.63e-9 Coronary artery disease; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg18402987 chr7:1209562 NA 0.5 6.89 0.39 4.15e-11 Longevity;Endometriosis; CESC cis rs1950626 0.623 rs2295657 chr14:101430620 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.69 9.41 0.5 2.44e-18 Pelvic organ prolapse (moderate/severe); CESC cis rs7649275 0.832 rs2577326 chr3:53780082 A/G cg21503701 chr3:53781065 CACNA1D -0.38 -5.08 -0.3 7.14e-7 Trans fatty acid levels; CESC cis rs7666738 0.830 rs62318472 chr4:98926030 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.31 0.31 2.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12476592 0.571 rs7577952 chr2:63787212 C/T cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs4481887 0.861 rs4295906 chr1:248429861 C/T cg00666640 chr1:248458726 OR2T12 0.39 6.7 0.38 1.23e-10 Common traits (Other); CESC cis rs7084402 0.934 rs1658453 chr10:60309602 T/C cg07615347 chr10:60278583 BICC1 0.59 9.34 0.5 4.21e-18 Refractive error; CESC cis rs11264213 0.901 rs72661607 chr1:36331411 G/C cg27506609 chr1:36549197 TEKT2 0.66 5.63 0.33 4.53e-8 Schizophrenia; CESC cis rs344364 0.511 rs1742395 chr16:1955965 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.53 -6.1 -0.35 3.81e-9 Glomerular filtration rate in chronic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13640924 chr14:105695311 BRF1 -0.53 -6.34 -0.36 9.87e-10 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs1925411 chr1:67370292 C/T cg02640540 chr1:67518911 SLC35D1 0.5 5.33 0.31 2.11e-7 Lymphocyte percentage of white cells; CESC cis rs9611565 0.546 rs5758430 chr22:42109844 G/T cg17376030 chr22:41985996 PMM1 -0.72 -7.68 -0.43 3.15e-13 Vitiligo; CESC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg00149659 chr3:10157352 C3orf10 0.7 8.38 0.46 3.2e-15 Alzheimer's disease; CESC trans rs10411161 0.702 rs17835311 chr19:52386781 A/C cg22319618 chr22:45562946 NUP50 -0.73 -7.12 -0.4 1.02e-11 Breast cancer; CESC cis rs11229555 1.000 rs12808544 chr11:58373221 C/A cg15696309 chr11:58395628 NA -0.43 -5.64 -0.33 4.3e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg12292205 chr6:26970375 C6orf41 0.53 5.91 0.34 1.04e-8 Intelligence (multi-trait analysis); CESC cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.13 0.35 3.25e-9 Hip circumference adjusted for BMI; CESC cis rs910316 0.967 rs12890371 chr14:75593839 T/C cg08847533 chr14:75593920 NEK9 1.01 19.64 0.77 1.3e-53 Height; CESC cis rs863345 0.604 rs10908653 chr1:158455353 A/G cg12129480 chr1:158549410 OR10X1 -0.36 -7.14 -0.4 8.83e-12 Pneumococcal bacteremia; CESC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg06873352 chr17:61820015 STRADA 0.71 12.11 0.6 3.78e-27 Prudent dietary pattern; CESC cis rs67072384 0.901 rs67288233 chr11:72458361 G/A cg04827223 chr11:72435913 ARAP1 -0.71 -6.96 -0.39 2.61e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs2742234 0.590 rs2503863 chr10:43667398 G/A cg15436174 chr10:43711423 RASGEF1A -0.5 -5.84 -0.34 1.5e-8 Hirschsprung disease; CESC cis rs4237845 0.537 rs4237844 chr12:58267987 A/G cg04478727 chr12:58166393 METTL1;FAM119B -0.46 -5.04 -0.3 8.8e-7 Intelligence (multi-trait analysis); CESC cis rs7131987 0.934 rs2216854 chr12:29423460 G/A cg09582351 chr12:29534625 ERGIC2 -0.31 -5.12 -0.3 5.78e-7 QT interval; CESC cis rs72634258 0.519 rs744001 chr1:7934557 G/A cg00042356 chr1:8021962 PARK7 0.61 6.02 0.35 5.71e-9 Inflammatory bowel disease; CESC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg08704250 chr15:31115839 NA 0.63 8.61 0.47 6.65e-16 Huntington's disease progression; CESC cis rs2243480 1.000 rs10807702 chr7:65767843 C/T cg13147721 chr7:65941812 NA -0.91 -8.33 -0.46 4.48e-15 Diabetic kidney disease; CESC cis rs4664330 1 rs4664330 chr2:161333128 G/C cg03641300 chr2:160917029 PLA2R1 -0.44 -5.64 -0.33 4.43e-8 Monocyte percentage of white cells; CESC cis rs9987353 0.566 rs6998368 chr8:9070288 G/C cg06636001 chr8:8085503 FLJ10661 -0.6 -7.14 -0.4 9.11e-12 Recombination measurement; CESC cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg26408565 chr15:76604113 ETFA -0.42 -6.21 -0.36 2.01e-9 Blood metabolite levels; CESC cis rs9911578 1.000 rs1971659 chr17:57004787 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.19 0.68 6.64e-38 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00270594 chr10:70716161 DDX21 0.54 6.69 0.38 1.3100000000000001e-10 Gut microbiome composition (summer); CESC cis rs6088590 0.561 rs2295444 chr20:33173883 C/T cg24642439 chr20:33292090 TP53INP2 0.63 8.39 0.46 2.84e-15 Coronary artery disease; CESC trans rs2075371 0.932 rs1862048 chr7:133978167 C/G cg06584028 chr2:69614451 GFPT1 0.56 6.37 0.36 8.46e-10 Mean platelet volume; CESC cis rs8111998 0.625 rs7255845 chr19:22766051 C/T cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs2011503 0.943 rs1529745 chr19:19517325 C/G cg11584989 chr19:19387371 SF4 0.62 7.32 0.41 3.06e-12 Bipolar disorder; CESC cis rs921968 0.678 rs689116 chr2:219433888 C/A cg02176678 chr2:219576539 TTLL4 0.41 7.08 0.4 1.29e-11 Mean corpuscular hemoglobin concentration; CESC cis rs75477785 0.590 rs72649925 chr1:210136902 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.86 5.83 0.34 1.65e-8 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23814154 chr12:51611356 POU6F1 -0.65 -7.55 -0.42 7.12e-13 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1348850 0.915 rs10930798 chr2:178446141 G/A cg23306229 chr2:178417860 TTC30B 0.54 7.1 0.4 1.16e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7605827 0.893 rs7589238 chr2:15606409 C/A cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg00149659 chr3:10157352 C3orf10 0.68 7.98 0.44 4.5e-14 Alzheimer's disease; CESC cis rs9457247 0.905 rs377232 chr6:167409638 C/A cg25258033 chr6:167368657 RNASET2 0.41 6.23 0.36 1.81e-9 Crohn's disease; CESC cis rs9399135 0.660 rs4440481 chr6:135276696 A/G cg22676075 chr6:135203613 NA 0.49 6.83 0.39 5.73e-11 Red blood cell count; CESC cis rs826838 0.967 rs1719853 chr12:39128515 A/G cg13010199 chr12:38710504 ALG10B -0.44 -5.97 -0.34 7.74e-9 Heart rate; CESC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg22535103 chr8:58192502 C8orf71 -1.05 -11.32 -0.57 1.73e-24 Developmental language disorder (linguistic errors); CESC cis rs61935443 0.720 rs10859785 chr12:95295081 A/T cg21533806 chr12:95267307 NA 0.53 6.48 0.37 4.54e-10 Schizophrenia; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -5.46 -0.32 1.09e-7 Electroencephalogram traits; CESC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg18876405 chr7:65276391 NA -0.65 -9.28 -0.5 6.26e-18 Calcium levels; CESC cis rs2635047 0.783 rs9948677 chr18:44790343 G/A cg24371990 chr18:44770781 NA 0.42 6.57 0.37 2.66e-10 Educational attainment; CESC cis rs2075371 0.932 rs1862052 chr7:133981227 G/A cg00033643 chr7:134001901 SLC35B4 0.4 5.12 0.3 5.81e-7 Mean platelet volume; CESC cis rs1371867 0.817 rs7846076 chr8:101327629 A/G cg11906718 chr8:101322791 RNF19A 0.5 6.51 0.37 3.78e-10 Atrioventricular conduction; CESC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg11645453 chr3:52864694 ITIH4 0.28 5.5 0.32 8.89e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs6076065 1.000 rs6083105 chr20:23368475 C/A cg12062639 chr20:23401060 NAPB 0.41 5.16 0.3 4.95e-7 Facial morphology (factor 15, philtrum width); CESC cis rs11792861 0.641 rs10979586 chr9:111647764 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.49 6.22 0.36 1.9e-9 Menarche (age at onset); CESC cis rs36051895 0.623 rs10975024 chr9:5246403 A/T cg02405213 chr9:5042618 JAK2 -0.52 -6.49 -0.37 4.27e-10 Pediatric autoimmune diseases; CESC cis rs6083 0.512 rs17269397 chr15:58857378 A/G cg05156742 chr15:59063176 FAM63B -0.72 -10.21 -0.53 7.23e-21 Schizophrenia; CESC cis rs1580019 0.563 rs764483 chr7:32578150 A/T cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.4 0.37 7e-10 Cognitive ability; CESC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs2370759 1.000 rs79578760 chr10:32611264 C/A cg18270830 chr10:32634957 EPC1 0.71 6.8 0.39 6.75e-11 Sexual dysfunction (female); CESC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.1e-18 Prudent dietary pattern; CESC cis rs2901656 0.934 rs2285176 chr1:172421744 G/A cg03748243 chr1:172413542 C1orf105;PIGC 0.41 5.93 0.34 9.27e-9 Red cell distribution width;Platelet distribution width; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg01953119 chr2:20425340 SDC1 -0.41 -6.1 -0.35 3.7e-9 Vertical cup-disc ratio; CESC cis rs4268898 0.679 rs2543666 chr2:24446042 C/T cg20701182 chr2:24300061 SF3B14 -0.5 -5.7 -0.33 3.17e-8 Asthma; CESC cis rs3806843 0.735 rs2530235 chr5:140072647 G/T cg16179182 chr5:140090404 VTRNA1-1 0.41 5.29 0.31 2.56e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1707322 1.000 rs10890380 chr1:46449469 A/G cg05343316 chr1:45956843 TESK2 0.45 5.54 0.32 7.24e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3736485 0.934 rs8036609 chr15:51861426 C/G cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9487051 0.676 rs7753697 chr6:109593292 A/G cg01475377 chr6:109611718 NA -0.44 -6.99 -0.39 2.19e-11 Reticulocyte fraction of red cells; CESC cis rs4835473 0.932 rs4835118 chr4:144903147 A/T cg25736465 chr4:144833511 NA 0.41 6.36 0.36 8.7e-10 Immature fraction of reticulocytes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20332471 chr1:2447853 PANK4 0.53 7.37 0.41 2.22e-12 Fibrinogen levels; CESC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.71 -0.33 3.04e-8 Total body bone mineral density; CESC cis rs6582630 0.502 rs11520234 chr12:38255005 G/A cg13010199 chr12:38710504 ALG10B 0.52 6.38 0.36 8.04e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs644799 0.710 rs56384142 chr11:95502075 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.77 11.59 0.58 2.13e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6662572 0.585 rs12042481 chr1:45964766 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.58 5.61 0.33 5.13e-8 Blood protein levels; CESC cis rs116095464 0.558 rs7356696 chr5:284251 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.77e-15 Breast cancer; CESC cis rs11764590 0.671 rs3800872 chr7:2110272 C/G cg27530443 chr7:1977877 MAD1L1 0.44 5.12 0.3 6.02e-7 Neuroticism; CESC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg09365446 chr1:150670422 GOLPH3L 0.41 5.76 0.33 2.36e-8 Tonsillectomy; CESC cis rs72945132 0.882 rs947812 chr11:70209169 C/T cg00319359 chr11:70116639 PPFIA1 0.78 7.36 0.41 2.3e-12 Coronary artery disease; CESC cis rs4481887 0.927 rs4350233 chr1:248489994 G/A cg00666640 chr1:248458726 OR2T12 0.36 6.17 0.35 2.56e-9 Common traits (Other); CESC cis rs8141529 0.748 rs2064261 chr22:29287730 C/T cg02153584 chr22:29168773 CCDC117 0.58 7.55 0.42 6.89e-13 Lymphocyte counts; CESC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg11494091 chr17:61959527 GH2 0.74 12.24 0.6 1.3e-27 Prudent dietary pattern; CESC trans rs61931739 0.517 rs10772139 chr12:34186178 A/T cg26384229 chr12:38710491 ALG10B 0.65 9.11 0.49 2.1e-17 Morning vs. evening chronotype; CESC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg07648498 chr16:89883185 FANCA 0.5 6.41 0.37 6.59e-10 Vitiligo; CESC cis rs10979 1.000 rs9376763 chr6:143887386 C/T cg25407410 chr6:143891975 LOC285740 -0.61 -9.13 -0.49 1.86e-17 Hypospadias; CESC cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg25324976 chr17:61989376 CSHL1 -0.33 -5.04 -0.3 8.68e-7 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18018640 chr7:2599151 IQCE 0.65 7.44 0.42 1.44e-12 Gut microbiome composition (summer); CESC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg17971929 chr21:40555470 PSMG1 -1.05 -15.98 -0.7 1.02e-40 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05511689 chr6:71123154 FAM135A 0.61 6.68 0.38 1.42e-10 Gut microbiome composition (summer); CESC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg05555928 chr11:63887634 MACROD1 0.34 5.12 0.3 5.86e-7 Platelet count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11087358 chr12:57940980 DCTN2 0.48 6.18 0.35 2.39e-9 Gut microbiota (bacterial taxa); CESC cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg04450456 chr4:17643702 FAM184B 0.37 5.23 0.31 3.4e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12476592 0.602 rs4671065 chr2:63791131 G/A cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs754466 0.580 rs1058198 chr10:79566632 G/A cg17075019 chr10:79541650 NA -0.83 -12.74 -0.62 2.47e-29 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1499972 0.941 rs55864156 chr3:117664968 C/G cg07612923 chr3:117604196 NA 0.89 7.41 0.41 1.71e-12 Schizophrenia; CESC cis rs9303280 0.517 rs12939566 chr17:38038390 A/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.42 -0.32 1.31e-7 Self-reported allergy; CESC cis rs28374715 0.681 rs28687846 chr15:41599902 C/T cg20272979 chr15:41787780 ITPKA 0.43 5.14 0.3 5.29e-7 Ulcerative colitis; CESC cis rs7707921 0.752 rs6882565 chr5:81356421 G/A cg15871215 chr5:81402204 ATG10 -0.44 -5.82 -0.34 1.68e-8 Breast cancer; CESC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg26939375 chr7:64535504 NA 0.76 10.85 0.55 6.19e-23 Calcium levels; CESC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC cis rs3747547 0.581 rs1928236 chr9:38132477 T/C cg13774184 chr9:37916125 SHB -0.65 -5.3 -0.31 2.4e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs13102973 0.931 rs12499856 chr4:135868573 C/T cg14419869 chr4:135874104 NA 0.36 5.75 0.33 2.45e-8 Subjective well-being; CESC cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg20476274 chr7:133979776 SLC35B4 0.67 9.79 0.52 1.65e-19 Mean platelet volume; CESC cis rs631288 0.793 rs7555913 chr1:146764442 G/T cg25205988 chr1:146714368 CHD1L 1.13 6.67 0.38 1.51e-10 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs1538970 1.000 rs17395553 chr1:45864761 C/T cg03146154 chr1:46216737 IPP 0.45 5.46 0.32 1.08e-7 Platelet count; CESC cis rs10883723 0.810 rs7094751 chr10:104274818 G/A cg22532475 chr10:104410764 TRIM8 -0.33 -5.68 -0.33 3.5e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs1707322 0.721 rs6429575 chr1:46134216 G/C cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg23281280 chr6:28129359 ZNF389 0.56 7.62 0.42 4.55e-13 Depression; CESC cis rs41271473 0.687 rs35637401 chr1:228883578 T/C cg00850481 chr1:228891306 NA -0.38 -5.15 -0.3 5e-7 Chronic lymphocytic leukemia; CESC cis rs67478160 0.595 rs67768834 chr14:104221085 C/G cg01849466 chr14:104193079 ZFYVE21 -0.49 -6.79 -0.38 7.51e-11 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03584783 chr1:173836803 GAS5;SNORD76;SNORD75;SNORD77;ZBTB37 -0.5 -6.29 -0.36 1.28e-9 Ulcerative colitis; CESC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg24818145 chr4:99064322 C4orf37 0.4 5.19 0.3 4.13e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04632724 chr15:102192393 TM2D3 0.56 6.34 0.36 9.99e-10 Gut microbiome composition (summer); CESC trans rs3198697 0.663 rs12928099 chr16:15150505 C/A cg04146151 chr16:2155961 PKD1 -0.61 -6.88 -0.39 4.4e-11 Triglycerides; CESC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg08704250 chr15:31115839 NA -0.62 -8.07 -0.44 2.4e-14 Huntington's disease progression; CESC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg22823121 chr1:150693482 HORMAD1 0.47 6.49 0.37 4.09e-10 Melanoma; CESC cis rs1580019 0.520 rs6945238 chr7:32646096 C/T cg06627557 chr7:32535165 LSM5;AVL9 -0.89 -10.75 -0.55 1.27e-22 Cognitive ability; CESC cis rs10463316 0.817 rs906679 chr5:150779302 T/A cg03212797 chr5:150827313 SLC36A1 -0.47 -5.9 -0.34 1.1e-8 Metabolite levels (Pyroglutamine); CESC cis rs6120849 0.754 rs11167253 chr20:33614449 T/C cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg27478167 chr7:817139 HEATR2 -0.5 -5.22 -0.31 3.56e-7 Cerebrospinal P-tau181p levels; CESC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg25036284 chr2:26402008 FAM59B -0.58 -6.72 -0.38 1.13e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15100112 chr5:64331517 NA 0.56 6.71 0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs6942407 0.546 rs2108272 chr7:86805399 C/T cg02420886 chr7:86849541 C7orf23 0.52 5.03 0.3 9.11e-7 Food allergy; CESC cis rs1538970 0.816 rs11211124 chr1:45962409 T/C cg03146154 chr1:46216737 IPP 0.49 5.57 0.32 6.31e-8 Platelet count; CESC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.27 -0.36 1.49e-9 Total body bone mineral density; CESC cis rs476633 0.691 rs28409265 chr15:41539404 G/A cg18705301 chr15:41695430 NDUFAF1 -0.48 -6.94 -0.39 2.95e-11 Glomerular filtration rate (creatinine); CESC trans rs10028773 0.515 rs9994651 chr4:120587803 C/T cg25214090 chr10:38739885 LOC399744 0.56 7.79 0.43 1.56e-13 Educational attainment; CESC cis rs113835537 0.935 rs75863187 chr11:66443461 G/A cg24851651 chr11:66362959 CCS 0.63 5.68 0.33 3.48e-8 Airway imaging phenotypes; CESC cis rs959260 1.000 rs12604003 chr17:73399598 G/A cg20590849 chr17:73267439 MIF4GD -0.59 -6.55 -0.37 3.01e-10 Systemic lupus erythematosus; CESC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg11742103 chr11:62369870 EML3;MTA2 0.65 9.87 0.52 9.19e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs7615952 0.576 rs6804482 chr3:125815762 C/T cg07211511 chr3:129823064 LOC729375 -0.57 -6.31 -0.36 1.15e-9 Blood pressure (smoking interaction); CESC cis rs4423214 1.000 rs3750997 chr11:71158841 A/C cg05163923 chr11:71159392 DHCR7 0.84 11.94 0.59 1.4e-26 Vitamin D levels; CESC cis rs34779708 0.931 rs68039650 chr10:35385499 C/A cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs875971 0.964 rs1643388 chr7:65844562 T/C cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.69e-9 Aortic root size; CESC cis rs79387448 0.592 rs76362690 chr2:102951477 A/G cg09003973 chr2:102972529 NA 1.08 8.1 0.45 2.05e-14 Gut microbiota (bacterial taxa); CESC cis rs4253772 0.515 rs9615969 chr22:46773592 C/G cg09491104 chr22:46646882 C22orf40 -0.58 -5.15 -0.3 5.03e-7 LDL cholesterol;Cholesterol, total; CESC cis rs3857067 0.806 rs10212784 chr4:95101638 C/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.01 -0.48 4.22e-17 QT interval; CESC cis rs9788682 0.947 rs7169584 chr15:78822660 A/T cg24631222 chr15:78858424 CHRNA5 0.76 9.77 0.51 1.88e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg11764359 chr7:65958608 NA 0.79 11.86 0.59 2.52e-26 Aortic root size; CESC cis rs854765 0.647 rs854808 chr17:18006634 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.35 0.46 3.95e-15 Total body bone mineral density; CESC cis rs9611565 0.559 rs132761 chr22:42004371 C/T cg06481639 chr22:41940642 POLR3H 0.61 6.26 0.36 1.56e-9 Vitiligo; CESC cis rs4820539 1.000 rs2267002 chr22:23456702 T/C cg14186256 chr22:23484241 RTDR1 0.83 15.26 0.68 3.56e-38 Bone mineral density; CESC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg10691866 chr7:65817282 TPST1 0.32 5.47 0.32 1.06e-7 Aortic root size; CESC cis rs9549367 0.789 rs7999579 chr13:113879357 T/C cg00898013 chr13:113819073 PROZ -0.49 -6.87 -0.39 4.59e-11 Platelet distribution width; CESC trans rs1814175 0.645 rs1851853 chr11:49953434 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC trans rs2727020 0.658 rs4980440 chr11:49386017 C/T cg03929089 chr4:120376271 NA -0.81 -12.68 -0.61 4.09e-29 Coronary artery disease; CESC trans rs7178375 1.000 rs9806159 chr15:31209654 G/T cg04373760 chr16:53404718 NA 0.53 7.3 0.41 3.38e-12 Hypertriglyceridemia; CESC cis rs7613875 0.543 rs34034116 chr3:49959156 C/A cg24110177 chr3:50126178 RBM5 -0.52 -7.12 -0.4 1.04e-11 Body mass index; CESC cis rs6696846 0.515 rs10900450 chr1:205106238 C/G cg00857998 chr1:205179979 DSTYK 0.39 5.32 0.31 2.26e-7 Red blood cell count; CESC cis rs1348850 0.561 rs1838890 chr2:178410938 C/A cg23306229 chr2:178417860 TTC30B 0.85 7.9 0.44 7.47e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6736093 0.796 rs34128716 chr2:112812856 C/G cg12686935 chr2:112915763 FBLN7 -0.43 -5.65 -0.33 4.2e-8 Coronary artery disease; CESC cis rs4481887 0.893 rs1934544 chr1:248505582 G/A cg00666640 chr1:248458726 OR2T12 0.35 6.04 0.35 5.14e-9 Common traits (Other); CESC trans rs17211056 0.744 rs2584281 chr18:73347313 C/T cg15724534 chr2:211018363 C2orf67 -0.64 -6.15 -0.35 2.81e-9 Serum uric acid levels in response to allopurinol in gout; CESC cis rs3806843 0.735 rs801168 chr5:140080298 A/G cg16179182 chr5:140090404 VTRNA1-1 0.42 5.43 0.32 1.26e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1256061 0.624 rs944046 chr14:64700299 G/A cg21174375 chr14:64681225 SYNE2 0.48 6.38 0.36 7.86e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg18404041 chr3:52824283 ITIH1 -0.41 -6.88 -0.39 4.42e-11 Bipolar disorder; CESC cis rs73001065 0.901 rs73004959 chr19:19711139 C/T cg03709012 chr19:19516395 GATAD2A 0.95 5.72 0.33 2.87e-8 LDL cholesterol; CESC cis rs950169 0.810 rs2879976 chr15:85109578 G/A cg17507749 chr15:85114479 UBE2QP1 0.56 6.35 0.36 9.37e-10 Schizophrenia; CESC cis rs832540 0.966 rs252923 chr5:56205662 T/G cg12311346 chr5:56204834 C5orf35 -0.46 -5.83 -0.34 1.59e-8 Coronary artery disease; CESC cis rs1109430 0.661 rs12405601 chr1:210143254 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.91 6.32 0.36 1.09e-9 Orofacial clefts; CESC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg24531977 chr5:56204891 C5orf35 0.7 9.51 0.5 1.21e-18 Initial pursuit acceleration; CESC cis rs6582630 0.555 rs10880607 chr12:38508184 A/G cg13010199 chr12:38710504 ALG10B 0.53 6.69 0.38 1.35e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs3105593 1.000 rs3109895 chr15:50880560 A/T cg08437265 chr15:50716283 USP8 0.42 5.49 0.32 9.52e-8 QT interval; CESC cis rs6088590 1.000 rs6058111 chr20:33310999 T/C cg24642439 chr20:33292090 TP53INP2 0.83 11.65 0.58 1.29e-25 Coronary artery disease; CESC cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs144345632 1 rs144345632 chr6:96886894 T/TA cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Facial morphology (factor 17, height of vermillion upper lip); CESC cis rs6912958 0.559 rs451465 chr6:88043372 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.74 -11.47 -0.58 5.19e-25 Monocyte percentage of white cells; CESC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg24642844 chr7:1081250 C7orf50 -0.67 -8.34 -0.46 3.98e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs698833 0.852 rs2241869 chr2:44549229 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.56 -7.19 -0.4 6.51e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg18876405 chr7:65276391 NA 0.52 6.98 0.39 2.44e-11 Aortic root size; CESC cis rs12136530 0.593 rs12125806 chr1:19734781 A/G cg01832549 chr1:19774989 CAPZB -0.44 -6.25 -0.36 1.64e-9 Lead levels in blood; CESC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.29e-7 Life satisfaction; CESC cis rs73591976 0.539 rs12446198 chr16:68125972 G/A cg26727032 chr16:67993705 SLC12A4 -0.53 -5.87 -0.34 1.31e-8 HDL cholesterol; CESC cis rs8020095 0.571 rs7157418 chr14:67562815 G/T cg19548862 chr14:67692701 FAM71D -0.47 -5.63 -0.33 4.6e-8 Depression (quantitative trait); CESC cis rs116095464 0.558 rs13356367 chr5:242395 C/T cg22857025 chr5:266934 NA -1.27 -18.37 -0.75 3.49e-49 Breast cancer; CESC cis rs921968 0.565 rs1529382 chr2:219626489 C/T cg02176678 chr2:219576539 TTLL4 -0.44 -7.74 -0.43 2.04e-13 Mean corpuscular hemoglobin concentration; CESC cis rs7851660 0.844 rs12343182 chr9:100624259 G/C cg13688889 chr9:100608707 NA -0.63 -8.95 -0.48 6.32e-17 Strep throat; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26815021 chr17:74733172 MIR636;MFSD11;SFRS2 0.48 6.28 0.36 1.36e-9 Gut microbiota (bacterial taxa); CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg07507251 chr3:52567010 NT5DC2 0.47 9.25 0.49 7.84e-18 Electroencephalogram traits; CESC cis rs12586317 0.620 rs17103042 chr14:35575428 T/C cg16230307 chr14:35515116 FAM177A1 0.92 9.94 0.52 5.62e-20 Psoriasis; CESC cis rs6460942 0.591 rs7800823 chr7:12378697 G/T cg20607287 chr7:12443886 VWDE -0.42 -6.52 -0.37 3.48e-10 Coronary artery disease; CESC trans rs1505368 0.817 rs6435701 chr2:213283512 A/G cg00572323 chr16:29706151 QPRT -0.38 -6.09 -0.35 3.89e-9 Symmetrical dimethylarginine levels; CESC cis rs2832191 0.740 rs2832168 chr21:30463695 G/A cg24692254 chr21:30365293 RNF160 1.0 17.21 0.73 4.53e-45 Dental caries; CESC cis rs3782089 0.744 rs11545200 chr11:65319751 G/A cg21890820 chr11:65308645 LTBP3 1.08 8.18 0.45 1.2e-14 Height; CESC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg15445000 chr17:37608096 MED1 -0.4 -6.38 -0.36 7.99e-10 Glomerular filtration rate (creatinine); CESC cis rs7586673 1.000 rs7586673 chr2:161923520 C/A cg22496339 chr2:162101262 NA 0.51 6.83 0.39 5.73e-11 Intelligence (multi-trait analysis); CESC trans rs656319 0.625 rs34427895 chr8:9875221 G/C cg06636001 chr8:8085503 FLJ10661 -0.5 -6.07 -0.35 4.36e-9 Myopia (pathological); CESC cis rs8114671 0.562 rs3746450 chr20:33508588 G/T cg07148914 chr20:33460835 GGT7 0.45 5.9 0.34 1.09e-8 Height; CESC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg10691866 chr7:65817282 TPST1 0.33 5.52 0.32 8.15e-8 Aortic root size; CESC cis rs9581857 0.547 rs74518675 chr13:27972180 A/G cg01674679 chr13:27998804 GTF3A -0.65 -5.12 -0.3 5.86e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg24641125 chr21:40721130 HMGN1 -0.5 -6.71 -0.38 1.18e-10 Breast cancer;Type 2 diabetes; CESC cis rs11112613 0.713 rs11112588 chr12:105943801 A/C cg03607813 chr12:105948248 NA 0.64 7.77 0.43 1.69e-13 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg06600287 chr1:53387719 ECHDC2 -0.28 -5.04 -0.3 8.52e-7 Monocyte count; CESC cis rs2228479 0.702 rs62056087 chr16:89920383 C/A cg06558623 chr16:89946397 TCF25 1.15 8.39 0.46 2.95e-15 Skin colour saturation; CESC cis rs1559088 0.948 rs2019603 chr19:33577367 C/T cg17764715 chr19:33622953 WDR88 -0.52 -6.9 -0.39 3.8e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs12586317 0.620 rs28870452 chr14:35536878 C/A cg16230307 chr14:35515116 FAM177A1 0.93 9.91 0.52 6.88e-20 Psoriasis; CESC cis rs6988985 0.530 rs57268571 chr8:143942602 A/G cg10324643 chr8:143916377 GML 0.34 5.08 0.3 7.11e-7 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CESC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg25934064 chr3:52569026 NT5DC2 0.3 6.09 0.35 3.99e-9 Electroencephalogram traits; CESC cis rs2204008 0.683 rs7305703 chr12:38138381 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.62 0.51 5.64e-19 Bladder cancer; CESC cis rs6500395 1.000 rs9930199 chr16:48571263 A/G cg04672837 chr16:48644449 N4BP1 0.49 6.08 0.35 4.07e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6752107 1.000 rs2289472 chr2:234182240 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.7 0.38 1.25e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg03351412 chr1:154909251 PMVK 0.68 9.09 0.49 2.32e-17 Prostate cancer; CESC trans rs17764205 0.929 rs8101372 chr19:3253830 T/C cg27384338 chr17:2031545 SMG6 -0.64 -6.02 -0.35 5.87e-9 Bipolar disorder and schizophrenia; CESC cis rs6598955 0.724 rs7547520 chr1:26592310 C/T cg00852783 chr1:26633632 UBXN11 0.43 6.27 0.36 1.45e-9 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05236530 chr12:7362357 PEX5 0.52 7.15 0.4 8.32e-12 Fibrinogen levels; CESC cis rs9902453 1.000 rs9896062 chr17:28357047 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.1e-13 Coffee consumption (cups per day); CESC cis rs6938 0.618 rs11072514 chr15:75221865 T/A cg17294928 chr15:75287854 SCAMP5 0.5 6.48 0.37 4.49e-10 Breast cancer; CESC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg06877462 chr1:205807181 PM20D1 0.37 5.35 0.31 1.91e-7 Menarche (age at onset); CESC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.82 10.41 0.54 1.63e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs9929218 1.000 rs13339591 chr16:68809273 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -8.03 -0.44 3.1e-14 Colorectal cancer; CESC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg19774624 chr17:42201019 HDAC5 0.65 9.27 0.49 6.87e-18 Total body bone mineral density; CESC cis rs9287719 0.967 rs6432117 chr2:10749359 G/C cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs9287719 0.967 rs6432121 chr2:10753804 G/C cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.32 -0.31 2.25e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs6701037 0.681 rs2285220 chr1:175130773 T/A cg00321850 chr1:175162397 KIAA0040 -0.43 -6.19 -0.36 2.33e-9 Alcohol dependence; CESC cis rs7927771 0.524 rs3758655 chr11:47703943 T/C cg20307385 chr11:47447363 PSMC3 0.61 8.46 0.46 1.87e-15 Subjective well-being; CESC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg27535305 chr1:53392650 SCP2 0.32 5.2 0.3 3.99e-7 Monocyte count; CESC cis rs2404602 0.716 rs66754747 chr15:76828568 G/A cg22467129 chr15:76604101 ETFA -0.35 -5.31 -0.31 2.33e-7 Blood metabolite levels; CESC cis rs8044868 0.586 rs12917999 chr16:72089451 T/C cg01557791 chr16:72042693 DHODH -0.42 -5.69 -0.33 3.29e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24694326 chr1:151162561 VPS72 0.68 7.44 0.42 1.38e-12 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg06420487 chr17:61919686 SMARCD2 0.44 5.3 0.31 2.43e-7 Height; CESC cis rs763121 0.925 rs1043312 chr22:39131727 T/G cg14440974 chr22:39074834 NA -0.36 -5.24 -0.31 3.27e-7 Menopause (age at onset); CESC cis rs11792861 0.781 rs2151426 chr9:111743797 A/C cg13535736 chr9:111863775 C9orf5 -0.44 -5.76 -0.33 2.36e-8 Menarche (age at onset); CESC cis rs6460942 0.915 rs10488158 chr7:12508894 C/T cg06484146 chr7:12443880 VWDE -0.76 -8.45 -0.46 1.97e-15 Coronary artery disease; CESC cis rs17293817 0.589 rs2805511 chr10:1427710 G/T cg04271617 chr10:1416546 ADARB2 0.3 5.05 0.3 8.36e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs9549260 0.651 rs57735994 chr13:41226561 C/G cg21288729 chr13:41239152 FOXO1 0.65 8.5 0.46 1.4e-15 Red blood cell count; CESC cis rs7224314 1.000 rs62084082 chr17:65388046 A/G cg01507342 chr17:65387096 PITPNC1 -0.48 -5.67 -0.33 3.82e-8 Diisocyanate-induced asthma; CESC cis rs116095464 0.558 rs7713524 chr5:276200 C/T cg22496380 chr5:211416 CCDC127 0.74 8.66 0.47 4.58e-16 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15392351 chr1:40563091 PPT1 0.59 6.39 0.37 7.25e-10 Gut microbiome composition (summer); CESC cis rs6546550 0.901 rs897120 chr2:70160982 C/T cg02498382 chr2:70120550 SNRNP27 0.4 6.82 0.39 6.25e-11 Prevalent atrial fibrillation; CESC cis rs9916302 0.904 rs34363096 chr17:37594294 G/A cg00129232 chr17:37814104 STARD3 -0.56 -7.35 -0.41 2.4e-12 Glomerular filtration rate (creatinine); CESC cis rs9487051 0.703 rs351755 chr6:109538073 G/A cg01475377 chr6:109611718 NA 0.39 5.8 0.34 1.87e-8 Reticulocyte fraction of red cells; CESC cis rs1018836 0.828 rs10091275 chr8:91559751 A/G cg16814680 chr8:91681699 NA -0.64 -9.15 -0.49 1.58e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs863345 0.967 rs11265002 chr1:158489063 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -5.97 -0.34 7.49e-9 Pneumococcal bacteremia; CESC cis rs6088590 0.561 rs6088528 chr20:33156742 G/A cg08999081 chr20:33150536 PIGU 0.7 12.32 0.6 6.97e-28 Coronary artery disease; CESC cis rs4450131 0.522 rs3781455 chr10:126347688 T/C cg20435097 chr10:126320824 FAM53B 0.28 5.09 0.3 6.88e-7 White blood cell count (basophil); CESC cis rs3026101 0.671 rs57085931 chr17:5305370 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC trans rs7819412 0.654 rs34741518 chr8:10776860 A/C cg15556689 chr8:8085844 FLJ10661 -0.61 -7.74 -0.43 2.1e-13 Triglycerides; CESC cis rs6032067 0.852 rs6032053 chr20:43829935 G/T cg10761708 chr20:43804764 PI3 0.52 6.32 0.36 1.07e-9 Blood protein levels; CESC cis rs963731 0.649 rs78510010 chr2:39348662 T/C cg04010122 chr2:39346883 SOS1 0.73 5.17 0.3 4.6e-7 Corticobasal degeneration; CESC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg16680214 chr1:154839983 KCNN3 -0.45 -6.95 -0.39 2.84e-11 Prostate cancer; CESC cis rs79349575 0.749 rs318093 chr17:46989354 A/G cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs904092 0.678 rs1230026 chr4:100185619 T/G cg12011299 chr4:100065546 ADH4 0.52 6.09 0.35 3.95e-9 Alcohol dependence; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg25061772 chr1:87794525 LMO4 -0.49 -6.03 -0.35 5.59e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs826838 0.967 rs11183022 chr12:38652519 G/A cg26384229 chr12:38710491 ALG10B 0.82 14.26 0.66 1.22e-34 Heart rate; CESC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg17724175 chr1:150552817 MCL1 0.41 6.36 0.36 8.58e-10 Melanoma; CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg18402987 chr7:1209562 NA 0.74 8.54 0.46 1.07e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12410462 0.502 rs77615958 chr1:227806083 T/C cg04117972 chr1:227635322 NA 0.77 5.42 0.32 1.37e-7 Major depressive disorder; CESC cis rs12142240 0.698 rs932816 chr1:46859749 G/A cg00530320 chr1:46809349 NSUN4 0.6 8.27 0.45 6.54e-15 Menopause (age at onset); CESC cis rs6662572 0.703 rs9429090 chr1:46502393 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.13 0.3 5.54e-7 Blood protein levels; CESC cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.53 6.53 0.37 3.4e-10 Multiple sclerosis; CESC cis rs11122272 0.705 rs1416914 chr1:231533196 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.05 -0.44 2.72e-14 Hemoglobin concentration; CESC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg18404041 chr3:52824283 ITIH1 0.43 6.77 0.38 8.21e-11 Bipolar disorder; CESC cis rs12956009 0.518 rs1434518 chr18:44833498 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.88 0.39 4.39e-11 Educational attainment (years of education); CESC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.77 0.38 8.42e-11 Bipolar disorder; CESC cis rs7605827 0.897 rs11684844 chr2:15640552 T/A cg19274914 chr2:15703543 NA 0.36 6.32 0.36 1.13e-9 Educational attainment (years of education); CESC cis rs6967414 1.000 rs6967414 chr7:6749758 G/A cg09896999 chr7:6746977 ZNF12 -0.51 -6.93 -0.39 3.16e-11 Hematocrit;Hemoglobin concentration; CESC cis rs2979489 0.891 rs4733495 chr8:30366883 A/G cg26383811 chr8:30366931 RBPMS 0.79 10.64 0.55 3.1e-22 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs36229146 1 rs36229146 chr7:22784486 TTATATATAAATATATATATATATATA/T cg05472934 chr7:22766657 IL6 0.91 11.59 0.58 2.11e-25 Eosinophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CESC cis rs79387448 0.655 rs17639215 chr2:102953444 G/A cg09003973 chr2:102972529 NA 1.1 8.42 0.46 2.42e-15 Gut microbiota (bacterial taxa); CESC cis rs9581857 0.615 rs9581849 chr13:28005782 G/T cg01674679 chr13:27998804 GTF3A -0.71 -5.67 -0.33 3.72e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs72945132 0.882 rs947781 chr11:70212755 G/A cg00319359 chr11:70116639 PPFIA1 0.73 7.04 0.4 1.67e-11 Coronary artery disease; CESC cis rs7216064 0.655 rs8078543 chr17:66037251 G/T cg12091567 chr17:66097778 LOC651250 0.87 11.51 0.58 3.91e-25 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs34779708 0.733 rs7914468 chr10:35548071 G/A cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg03388025 chr16:89894329 SPIRE2 0.41 7.9 0.44 7.6e-14 Vitiligo; CESC cis rs10392 0.543 rs3752292 chr20:37570475 G/A cg27552599 chr20:37590471 DHX35 0.38 5.74 0.33 2.62e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs7223966 0.729 rs2003549 chr17:62008437 C/T cg11494091 chr17:61959527 GH2 0.4 5.19 0.3 4.29e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9325144 0.560 rs2387924 chr12:38662883 A/G cg26384229 chr12:38710491 ALG10B -0.62 -9.6 -0.51 6.43e-19 Morning vs. evening chronotype; CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg07157834 chr1:205819609 PM20D1 0.81 13.02 0.62 2.83e-30 Menarche (age at onset); CESC trans rs9391997 0.568 rs7454545 chr6:434348 A/G cg18341491 chr13:38174258 POSTN 0.32 6.18 0.35 2.37e-9 Chronic lymphocytic leukemia; CESC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6540559 0.673 rs4556361 chr1:210019654 C/G cg25204440 chr1:209979598 IRF6 -0.56 -5.81 -0.34 1.81e-8 Cleft lip with or without cleft palate; CESC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg10494973 chr17:80897199 TBCD 0.51 5.91 0.34 1.07e-8 Breast cancer; CESC cis rs3749237 0.964 rs34522271 chr3:49808517 A/G cg03060546 chr3:49711283 APEH 0.64 7.52 0.42 8.74e-13 Resting heart rate; CESC cis rs1962636 1 rs1962636 chr16:22064395 A/C cg07571928 chr16:22020630 C16orf52 0.32 5.49 0.32 9.5e-8 Schizophrenia; CESC cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1018836 0.923 rs9693182 chr8:91621876 T/C cg16814680 chr8:91681699 NA -0.72 -10.07 -0.53 2.11e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01163298 chr12:49393408 DDN -0.47 -6.46 -0.37 4.89e-10 Gut microbiota (bacterial taxa); CESC cis rs2243480 0.764 rs2460423 chr7:65601216 A/T cg12463550 chr7:65579703 CRCP 0.74 5.75 0.33 2.42e-8 Diabetic kidney disease; CESC cis rs9443645 0.527 rs36128361 chr6:79684340 C/G cg05283184 chr6:79620031 NA -0.35 -5.11 -0.3 6.1e-7 Intelligence (multi-trait analysis); CESC cis rs763014 0.898 rs916416 chr16:632198 T/A cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC trans rs2727020 0.701 rs7949044 chr11:49597334 C/T cg03929089 chr4:120376271 NA -0.73 -9.16 -0.49 1.46e-17 Coronary artery disease; CESC cis rs1707322 0.963 rs12145287 chr1:46325002 C/G cg03146154 chr1:46216737 IPP 0.78 10.75 0.55 1.29e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg24549020 chr5:56110836 MAP3K1 0.66 7.5 0.42 9.87e-13 Initial pursuit acceleration; CESC cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg26597838 chr10:835615 NA 0.85 8.99 0.48 4.92e-17 Eosinophil percentage of granulocytes; CESC cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg20503657 chr10:835505 NA 0.78 8.23 0.45 8.52e-15 Eosinophil percentage of granulocytes; CESC cis rs1927790 0.667 rs7981845 chr13:96942533 C/T cg02571835 chr13:96230311 CLDN10 -0.4 -5.73 -0.33 2.74e-8 Body mass index; CESC cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg14983838 chr19:29218262 NA 0.45 6.11 0.35 3.51e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg15017067 chr4:17643749 FAM184B 0.38 5.35 0.31 1.86e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2832191 1.000 rs8131214 chr21:30483386 T/G cg24692254 chr21:30365293 RNF160 -0.74 -10.95 -0.56 2.98e-23 Dental caries; CESC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg02018176 chr4:1364513 KIAA1530 0.45 6.22 0.36 1.88e-9 Longevity; CESC trans rs163030 0.902 rs388924 chr5:76738247 A/G cg26150533 chr8:82396069 FABP4 -0.39 -6.0 -0.35 6.49e-9 Caudate nucleus volume; CESC cis rs9457247 1.000 rs398278 chr6:167388169 A/G cg25258033 chr6:167368657 RNASET2 0.36 5.32 0.31 2.16e-7 Crohn's disease; CESC cis rs35110281 0.807 rs4818850 chr21:45028071 T/G cg21573476 chr21:45109991 RRP1B -0.46 -6.37 -0.36 8.55e-10 Mean corpuscular volume; CESC cis rs3020736 0.500 rs4147641 chr22:42482502 C/G cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC cis rs4423214 0.798 rs12224205 chr11:71180992 A/G cg05163923 chr11:71159392 DHCR7 -0.72 -8.81 -0.48 1.65e-16 Vitamin D levels; CESC cis rs4925386 0.681 rs2427294 chr20:60927257 G/A cg24112000 chr20:60950667 NA -0.46 -5.77 -0.33 2.18e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg25204440 chr1:209979598 IRF6 0.66 8.3 0.45 5.31e-15 Cleft lip with or without cleft palate; CESC trans rs877282 0.898 rs11253338 chr10:759559 C/T cg22713356 chr15:30763199 NA 0.84 7.7 0.43 2.79e-13 Uric acid levels; CESC cis rs6570726 0.935 rs408768 chr6:145871735 A/G cg23711669 chr6:146136114 FBXO30 0.8 11.92 0.59 1.67e-26 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02105261 chr17:1945138 DPH1;OVCA2 0.55 6.12 0.35 3.33e-9 Gut microbiome composition (summer); CESC cis rs2637266 1.000 rs2579747 chr10:78327759 C/T cg18941641 chr10:78392320 NA 0.41 7.48 0.42 1.13e-12 Pulmonary function; CESC cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg09035930 chr12:129282057 SLC15A4 0.76 10.75 0.55 1.32e-22 Systemic lupus erythematosus; CESC cis rs9640161 0.830 rs13307276 chr7:150061525 T/C cg10018233 chr7:150070692 REPIN1 0.38 5.87 0.34 1.32e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg13393036 chr8:95962371 TP53INP1 -0.5 -10.56 -0.54 5.46e-22 Type 2 diabetes; CESC cis rs12971120 1.000 rs2278162 chr18:72175814 A/G cg26446133 chr18:72167187 CNDP2 -0.77 -10.02 -0.52 2.97e-20 Refractive error; CESC cis rs1215050 0.740 rs1648568 chr4:98957619 A/G cg05340658 chr4:99064831 C4orf37 -0.54 -7.3 -0.41 3.3e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.16 0.4 8.18e-12 Electroencephalogram traits; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12815271 chr11:65625153 CFL1 -0.53 -6.76 -0.38 8.55e-11 Asthma; CESC cis rs6426558 0.537 rs2813969 chr1:227404082 T/C cg10327440 chr1:227177885 CDC42BPA 0.5 6.36 0.36 9.03e-10 Neutrophil percentage of white cells; CESC cis rs2832191 0.703 rs2853827 chr21:30443596 T/C cg24692254 chr21:30365293 RNF160 1.0 17.4 0.73 9.35e-46 Dental caries; CESC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg03452623 chr4:187889614 NA -0.88 -15.6 -0.69 2.23e-39 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24941513 chr1:220267397 IARS2 0.57 6.15 0.35 2.87e-9 Gut microbiome composition (summer); CESC trans rs2727020 0.718 rs1404366 chr11:49415899 T/A cg03929089 chr4:120376271 NA -0.69 -8.16 -0.45 1.32e-14 Coronary artery disease; CESC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.36 -6.13 -0.35 3.17e-9 Bipolar disorder; CESC trans rs17685 0.735 rs11763339 chr7:75761541 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.41 0.61 3.51e-28 Coffee consumption;Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08115172 chr1:1990868 PRKCZ -0.55 -6.26 -0.36 1.54e-9 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04822973 chr14:68086311 ARG2 -0.41 -6.06 -0.35 4.67e-9 Gambling; CESC cis rs4889855 0.505 rs8082303 chr17:78605012 A/G cg16591659 chr17:78472290 NA -0.34 -5.49 -0.32 9.53e-8 Fractional excretion of uric acid; CESC cis rs7927771 0.965 rs3817335 chr11:47643891 T/A cg20307385 chr11:47447363 PSMC3 -0.5 -6.16 -0.35 2.7e-9 Subjective well-being; CESC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.5 -5.86 -0.34 1.38e-8 Prudent dietary pattern; CESC cis rs926938 0.583 rs12401670 chr1:115244337 C/T cg12756093 chr1:115239321 AMPD1 -0.49 -5.79 -0.34 1.94e-8 Autism; CESC cis rs12477438 0.798 rs1993230 chr2:99686079 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs10129255 0.957 rs7493713 chr14:107191922 T/C cg23076370 chr14:107095027 NA -0.47 -5.93 -0.34 9.55e-9 Kawasaki disease; CESC cis rs1348850 0.574 rs4893835 chr2:178442592 T/C cg23306229 chr2:178417860 TTC30B 0.59 5.8 0.34 1.86e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9291683 0.566 rs13115776 chr4:10040189 C/G cg00071950 chr4:10020882 SLC2A9 0.82 14.01 0.65 9.72e-34 Bone mineral density; CESC cis rs1348850 0.519 rs13034781 chr2:178523550 C/A cg22681709 chr2:178499509 PDE11A -0.49 -7.08 -0.4 1.29e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.38 6.09 0.35 3.87e-9 Monocyte percentage of white cells; CESC trans rs208520 0.802 rs4710314 chr6:66883656 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.49 -0.58 4.62e-25 Exhaled nitric oxide output; CESC cis rs9457247 0.663 rs9295384 chr6:167448113 T/A cg23791538 chr6:167370224 RNASET2 -0.56 -7.61 -0.42 4.78e-13 Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00365569 chr17:17876108 TOM1L2;LRRC48 0.52 6.71 0.38 1.15e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg20243544 chr17:37824526 PNMT 0.49 6.17 0.35 2.55e-9 Glomerular filtration rate (creatinine); CESC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg11644478 chr21:40555479 PSMG1 0.81 12.04 0.59 6.61e-27 Cognitive function; CESC cis rs3733585 0.699 rs12498956 chr4:9950705 G/T cg00071950 chr4:10020882 SLC2A9 -0.71 -12.0 -0.59 8.62e-27 Cleft plate (environmental tobacco smoke interaction); CESC trans rs2727020 0.521 rs7114564 chr11:49571231 C/T cg03929089 chr4:120376271 NA 0.7 7.99 0.44 4.25e-14 Coronary artery disease; CESC cis rs2243480 1.000 rs6949812 chr7:65387101 G/A cg13147721 chr7:65941812 NA -0.86 -8.15 -0.45 1.48e-14 Diabetic kidney disease; CESC cis rs62158211 0.955 rs7556815 chr2:114085785 G/A cg17784749 chr2:114082611 LOC440839 0.74 8.46 0.46 1.88e-15 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CESC cis rs61931739 0.500 rs34167298 chr12:34534338 G/A cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs9359856 0.510 rs4053618 chr6:90459454 G/A cg13799429 chr6:90582589 CASP8AP2 0.69 7.7 0.43 2.73e-13 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00244634 chr12:100661419 SCYL2;DEPDC4 0.61 7.33 0.41 2.83e-12 Gut microbiome composition (summer); CESC cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg08392591 chr16:89556376 ANKRD11 0.44 5.7 0.33 3.23e-8 Multiple myeloma (IgH translocation); CESC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg13880726 chr7:1868755 MAD1L1 0.51 6.75 0.38 9.19e-11 Bipolar disorder and schizophrenia; CESC cis rs2576037 0.796 rs2571030 chr18:44573854 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.44 5.64 0.33 4.28e-8 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03118206 chr6:138482933 KIAA1244 0.58 6.55 0.37 2.9e-10 Gut microbiome composition (summer); CESC cis rs2274273 1.000 rs1009977 chr14:55603002 T/G cg04306507 chr14:55594613 LGALS3 0.31 6.2 0.36 2.15e-9 Protein biomarker; CESC cis rs801193 0.901 rs4273746 chr7:66301111 C/T cg11764359 chr7:65958608 NA -0.63 -7.6 -0.42 5.19e-13 Aortic root size; CESC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg06456125 chr7:65229604 NA -0.45 -5.83 -0.34 1.61e-8 Corneal structure; CESC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg24675658 chr1:53192096 ZYG11B -0.57 -7.01 -0.4 1.98e-11 Monocyte count; CESC cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg06697600 chr4:7070879 GRPEL1 -0.48 -7.22 -0.41 5.58e-12 Monocyte percentage of white cells; CESC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg27266060 chr8:22091797 NA 0.37 7.37 0.41 2.15e-12 Hypertriglyceridemia; CESC cis rs1005277 0.505 rs7069702 chr10:38247359 G/T cg25517755 chr10:38738941 LOC399744 0.39 5.04 0.3 8.59e-7 Extrinsic epigenetic age acceleration; CESC cis rs9948 0.867 rs17119598 chr2:97486315 A/G cg01990225 chr2:97406019 LMAN2L 0.74 5.42 0.32 1.34e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs5769765 0.908 rs9616216 chr22:50318927 T/C cg26441486 chr22:50317300 CRELD2 0.48 5.78 0.33 2.08e-8 Schizophrenia; CESC cis rs7909074 1.000 rs10900128 chr10:45393201 G/T cg05187965 chr10:45406764 TMEM72 -0.33 -5.13 -0.3 5.61e-7 Mean corpuscular volume; CESC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.55 0.37 2.91e-10 Prudent dietary pattern; CESC cis rs6831352 0.918 rs7670638 chr4:100059807 G/C cg12011299 chr4:100065546 ADH4 -0.59 -6.59 -0.38 2.35e-10 Alcohol dependence; CESC cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg20476274 chr7:133979776 SLC35B4 0.59 8.31 0.45 5e-15 Mean platelet volume; CESC cis rs546131 0.890 rs485845 chr11:34830389 G/T cg11058730 chr11:34937778 PDHX;APIP -0.43 -5.16 -0.3 4.9e-7 Lung disease severity in cystic fibrosis; CESC cis rs796364 0.951 rs1105964 chr2:201000776 T/A cg23649088 chr2:200775458 C2orf69 -0.54 -5.39 -0.31 1.53e-7 Schizophrenia; CESC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg04317338 chr11:64019027 PLCB3 0.48 5.77 0.33 2.16e-8 Platelet count; CESC cis rs4919087 0.748 rs701815 chr10:98975893 A/C cg25902810 chr10:99078978 FRAT1 -0.5 -5.74 -0.33 2.54e-8 Monocyte count; CESC cis rs4835473 0.932 rs4585249 chr4:144902326 A/G cg25736465 chr4:144833511 NA -0.39 -6.11 -0.35 3.59e-9 Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27314324 chr1:112476724 KCND3 -0.45 -6.06 -0.35 4.69e-9 Gut microbiome composition (summer); CESC cis rs2425143 1.000 rs55761608 chr20:34344226 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.67 5.92 0.34 1.01e-8 Blood protein levels; CESC cis rs864537 0.646 rs1773542 chr1:167432949 T/C cg22356347 chr1:167427500 CD247 -0.37 -7.65 -0.43 3.84e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs28489187 0.643 rs233054 chr1:85840191 T/G cg16011679 chr1:85725395 C1orf52 0.53 6.21 0.36 2.08e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4144743 1.000 rs4541130 chr17:45321037 G/A cg18085866 chr17:45331354 ITGB3 -0.65 -7.07 -0.4 1.39e-11 Body mass index; CESC trans rs2727020 0.704 rs4144700 chr11:49370834 C/A cg03929089 chr4:120376271 NA -0.79 -11.97 -0.59 1.09e-26 Coronary artery disease; CESC cis rs1005277 0.522 rs1208767 chr10:38042295 G/T cg25427524 chr10:38739819 LOC399744 -0.64 -9.43 -0.5 2.24e-18 Extrinsic epigenetic age acceleration; CESC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg22903471 chr2:27725779 GCKR -0.55 -7.77 -0.43 1.69e-13 Total body bone mineral density; CESC cis rs1124376 1.000 rs73038113 chr3:20139025 T/A cg05072819 chr3:20081367 KAT2B 0.54 5.93 0.34 9.47e-9 Bipolar disorder and schizophrenia; CESC cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.86 -13.01 -0.62 2.89e-30 Systemic lupus erythematosus; CESC trans rs9467711 0.606 rs9358935 chr6:26369587 A/G cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg25036284 chr2:26402008 FAM59B -0.58 -6.79 -0.38 7.5e-11 Gut microbiome composition (summer); CESC cis rs4330281 0.715 rs4908940 chr3:17797271 A/C cg20981856 chr3:17787350 NA 0.35 5.05 0.3 8.36e-7 Schizophrenia; CESC cis rs2295499 0.610 rs12502642 chr4:2714023 T/C cg27239842 chr4:2403781 ZFYVE28 -0.34 -5.67 -0.33 3.67e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs7551222 0.749 rs7532236 chr1:204561617 A/G cg20240347 chr1:204465584 NA 0.27 5.57 0.32 6.33e-8 Schizophrenia; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg09031165 chr17:17586474 RAI1 0.46 6.08 0.35 4.14e-9 Weight; CESC cis rs7503807 0.967 rs8064502 chr17:78562434 C/A cg09596252 chr17:78655493 RPTOR 0.46 6.29 0.36 1.27e-9 Obesity; CESC cis rs1008375 0.932 rs12500947 chr4:17603424 C/T cg16339924 chr4:17578868 LAP3 0.68 8.73 0.47 2.9e-16 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09188840 chr17:4699533 PSMB6 0.58 6.2 0.36 2.16e-9 Gut microbiome composition (summer); CESC cis rs8177179 0.967 rs4287912 chr3:133437778 A/G cg16262614 chr3:133464971 TF 0.38 7.48 0.42 1.11e-12 Iron status biomarkers (transferrin levels); CESC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg03351412 chr1:154909251 PMVK 0.59 7.57 0.42 6.1e-13 Prostate cancer; CESC trans rs1814175 0.588 rs10466497 chr11:49864381 A/T cg11707556 chr5:10655725 ANKRD33B -0.42 -6.2 -0.36 2.17e-9 Height; CESC trans rs17685 0.712 rs869805 chr7:75688596 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 12.38 0.61 4.45e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs9487051 0.676 rs13210693 chr6:109598964 A/G cg21918786 chr6:109611834 NA 0.38 5.58 0.32 5.93e-8 Reticulocyte fraction of red cells; CESC cis rs72781680 0.679 rs718138 chr2:23976324 G/A cg08917208 chr2:24149416 ATAD2B 0.57 5.63 0.33 4.62e-8 Lymphocyte counts; CESC cis rs2463822 1.000 rs2463822 chr11:62103420 T/C cg06239285 chr11:62104954 ASRGL1 0.99 8.95 0.48 6.5e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg15687780 chr3:184294839 EPHB3 -0.49 -6.61 -0.38 2.1e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg04414720 chr1:150670196 GOLPH3L 0.61 8.59 0.47 7.48e-16 Tonsillectomy; CESC cis rs11871801 0.846 rs4792923 chr17:40690118 G/C cg21433558 chr17:40837037 CNTNAP1 -0.45 -5.1 -0.3 6.33e-7 Crohn's disease; CESC cis rs4481887 0.927 rs4523548 chr1:248472399 G/T cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs9479482 0.967 rs1543547 chr6:150346532 T/C cg03788504 chr6:150331562 NA -0.3 -5.81 -0.34 1.79e-8 Alopecia areata; CESC cis rs11098499 0.955 rs7685268 chr4:120162188 G/A cg24375607 chr4:120327624 NA 0.43 5.24 0.31 3.34e-7 Corneal astigmatism; CESC cis rs3780486 0.801 rs10971424 chr9:33138775 T/C cg13443165 chr9:33130375 B4GALT1 0.44 6.37 0.36 8.54e-10 IgG glycosylation; CESC cis rs7084402 0.967 rs1649045 chr10:60327047 T/C cg07615347 chr10:60278583 BICC1 0.6 9.38 0.5 3.01e-18 Refractive error; CESC cis rs11077998 0.903 rs8064554 chr17:80501093 A/G cg10255544 chr17:80519551 FOXK2 0.54 8.77 0.47 2.16e-16 Reticulocyte fraction of red cells; CESC cis rs2228479 0.717 rs11649210 chr16:89807233 C/G cg00800038 chr16:89945340 TCF25 -0.65 -6.51 -0.37 3.8e-10 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16105075 chr15:62682529 NA 0.56 6.04 0.35 5.25e-9 Gut microbiome composition (summer); CESC trans rs61931739 0.500 rs11053282 chr12:34561151 T/C cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC trans rs61931739 0.500 rs7965421 chr12:34523624 G/T cg13010199 chr12:38710504 ALG10B 0.5 6.42 0.37 6.3e-10 Morning vs. evening chronotype; CESC cis rs4803468 0.967 rs892044 chr19:41903671 A/G cg09537434 chr19:41945824 ATP5SL -1.02 -18.28 -0.75 7.49e-49 Height; CESC cis rs1005277 0.522 rs289650 chr10:37975505 G/T cg25427524 chr10:38739819 LOC399744 -0.61 -8.92 -0.48 7.65e-17 Extrinsic epigenetic age acceleration; CESC cis rs3105593 0.933 rs3105592 chr15:50870271 C/T cg08437265 chr15:50716283 USP8 -0.41 -5.41 -0.32 1.4e-7 QT interval; CESC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.41 -0.32 1.44e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg21285383 chr16:89894308 SPIRE2 0.3 5.39 0.31 1.6e-7 Vitiligo; CESC cis rs4746818 1.000 rs906217 chr10:70954661 T/C cg11621586 chr10:70884670 VPS26A 0.85 8.42 0.46 2.46e-15 Left atrial antero-posterior diameter; CESC cis rs17253792 0.822 rs78429067 chr14:56092551 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg26314531 chr2:26401878 FAM59B -0.62 -6.92 -0.39 3.46e-11 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg22823121 chr1:150693482 HORMAD1 0.48 7.0 0.4 2.04e-11 Tonsillectomy; CESC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg05535760 chr7:792225 HEATR2 1.01 11.54 0.58 3.23e-25 Cerebrospinal P-tau181p levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15864317 chr7:57485543 NA 0.38 6.24 0.36 1.77e-9 Fibrinogen levels; CESC cis rs7772486 0.743 rs62433835 chr6:146032688 C/G cg23711669 chr6:146136114 FBXO30 -0.82 -12.04 -0.59 6.45e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7264396 0.563 rs2425090 chr20:34304783 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.64 -0.55 3.06e-22 Total cholesterol levels; CESC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg26314531 chr2:26401878 FAM59B 0.7 7.48 0.42 1.12e-12 Gut microbiome composition (summer); CESC cis rs1048238 0.506 rs698889 chr1:16267040 A/C cg21385522 chr1:16154831 NA -0.43 -5.33 -0.31 2.1e-7 Systolic blood pressure; CESC cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg04450456 chr4:17643702 FAM184B 0.36 5.15 0.3 5.16e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs763121 0.889 rs2267390 chr22:38889657 C/T cg06022373 chr22:39101656 GTPBP1 0.81 11.83 0.59 3.18e-26 Menopause (age at onset); CESC cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.18 0.3 4.41e-7 Colonoscopy-negative controls vs population controls; CESC trans rs9929218 0.817 rs3114404 chr16:68722096 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -10.05 -0.53 2.5e-20 Colorectal cancer; CESC cis rs782590 0.574 rs12991445 chr2:55675939 C/T cg18811423 chr2:55921094 PNPT1 0.43 5.95 0.34 8.68e-9 Metabolic syndrome; CESC cis rs2645424 0.530 rs1293303 chr8:11720227 C/G cg21281001 chr8:11725306 CTSB -0.52 -6.48 -0.37 4.57e-10 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); CESC cis rs7429990 0.965 rs13075795 chr3:48024629 A/T cg11946769 chr3:48343235 NME6 -0.44 -5.37 -0.31 1.75e-7 Educational attainment (years of education); CESC cis rs7481584 1.000 rs12798150 chr11:3019260 C/T cg25174290 chr11:3078921 CARS -0.43 -5.32 -0.31 2.16e-7 Calcium levels; CESC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg17372223 chr3:52568218 NT5DC2 0.42 6.35 0.36 9.4e-10 Bipolar disorder; CESC cis rs870825 0.616 rs28607131 chr4:185651617 A/G cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.74e-11 Blood protein levels; CESC cis rs637571 0.607 rs589253 chr11:65693080 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.48 5.84 0.34 1.53e-8 Eosinophil percentage of white cells; CESC cis rs2066819 1.000 rs11575231 chr12:56744445 T/C cg26714650 chr12:56694279 CS -1.39 -9.17 -0.49 1.37e-17 Psoriasis vulgaris; CESC cis rs6426558 0.537 rs648877 chr1:227283614 A/G cg10327440 chr1:227177885 CDC42BPA 0.48 5.86 0.34 1.34e-8 Neutrophil percentage of white cells; CESC cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg11764359 chr7:65958608 NA 0.64 8.12 0.45 1.79e-14 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04846540 chr14:35183905 CFL2 -0.48 -6.35 -0.36 9.28e-10 Fibrinogen levels; CESC cis rs7586879 1.000 rs1865687 chr2:25112885 G/A cg01884057 chr2:25150051 NA 0.28 5.12 0.3 5.86e-7 Body mass index; CESC cis rs2274273 0.615 rs17672058 chr14:55673394 C/T cg04306507 chr14:55594613 LGALS3 0.31 5.24 0.31 3.34e-7 Protein biomarker; CESC cis rs6688613 0.545 rs10800270 chr1:166827602 A/T cg07049167 chr1:166818506 POGK 0.42 5.1 0.3 6.34e-7 Refractive astigmatism; CESC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg02569458 chr12:86230093 RASSF9 0.48 7.58 0.42 5.99e-13 Major depressive disorder; CESC cis rs2017305 0.834 rs12242235 chr10:70782556 A/T cg01024728 chr10:70782572 NA 0.56 5.38 0.31 1.67e-7 Depression (quantitative trait); CESC cis rs919433 0.783 rs787980 chr2:198239225 C/T cg03934865 chr2:198174659 NA 0.44 6.27 0.36 1.49e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs10781543 0.763 rs10781539 chr9:139320965 G/A cg14169450 chr9:139327907 INPP5E 0.5 7.7 0.43 2.79e-13 Monocyte percentage of white cells; CESC cis rs6120849 0.754 rs6119560 chr20:33606977 G/C cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs79057730 0.599 rs79272827 chr7:807015 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.88 7.39 0.41 1.91e-12 Initial pursuit acceleration; CESC cis rs6831352 0.879 rs56272995 chr4:100060882 A/G cg13256891 chr4:100009986 ADH5 -0.75 -8.21 -0.45 9.89e-15 Alcohol dependence; CESC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg17971929 chr21:40555470 PSMG1 0.93 12.53 0.61 1.32e-28 Cognitive function; CESC cis rs6723226 0.572 rs176404 chr2:32638846 T/C cg02381751 chr2:32503542 YIPF4 -0.53 -6.94 -0.39 2.95e-11 Intelligence (multi-trait analysis); CESC cis rs3762637 1.000 rs16845530 chr3:122142447 T/C cg24169773 chr3:122142474 KPNA1 -0.53 -6.36 -0.36 8.82e-10 LDL cholesterol levels; CESC cis rs11785693 0.862 rs11786595 chr8:5001621 T/G cg26367366 chr8:4980734 NA 0.81 7.76 0.43 1.88e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs698833 0.852 rs698823 chr2:44720947 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 6.02 0.35 5.68e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs317689 0.690 rs604168 chr12:69671158 C/T cg20891283 chr12:69753455 YEATS4 0.47 5.12 0.3 5.88e-7 Response to diuretic therapy; CESC cis rs854765 0.647 rs854808 chr17:18006634 C/T cg04398451 chr17:18023971 MYO15A -0.8 -11.86 -0.59 2.52e-26 Total body bone mineral density; CESC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg16405210 chr4:1374714 KIAA1530 -0.6 -8.29 -0.45 5.79e-15 Longevity; CESC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg08859206 chr1:53392774 SCP2 -0.57 -7.41 -0.41 1.68e-12 Monocyte count; CESC cis rs72781680 0.716 rs2712061 chr2:24026411 G/A cg08917208 chr2:24149416 ATAD2B 0.61 5.99 0.35 6.76e-9 Lymphocyte counts; CESC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg00166722 chr3:10149974 C3orf24 0.5 6.31 0.36 1.19e-9 Alzheimer's disease; CESC cis rs4466137 0.553 rs16898 chr5:82986149 T/C cg16102102 chr5:83017553 HAPLN1 -0.33 -5.21 -0.3 3.78e-7 Prostate cancer; CESC cis rs2288073 0.801 rs10175668 chr2:24367275 G/A cg06627628 chr2:24431161 ITSN2 -0.71 -9.18 -0.49 1.31e-17 Venous thromboembolism (SNP x SNP interaction); CESC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg20887711 chr4:1340912 KIAA1530 0.55 7.82 0.43 1.24e-13 Longevity; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg04234412 chr22:24373322 LOC391322 -0.73 -11.4 -0.57 9.02e-25 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12586317 0.511 rs11540758 chr14:35498485 C/T cg05294307 chr14:35346193 BAZ1A -0.51 -5.4 -0.31 1.49e-7 Psoriasis; CESC cis rs4481887 0.745 rs4540687 chr1:248476099 C/G cg00666640 chr1:248458726 OR2T12 0.36 6.12 0.35 3.33e-9 Common traits (Other); CESC cis rs9486719 0.843 rs3849198 chr6:97036539 C/A cg06623918 chr6:96969491 KIAA0776 -0.8 -8.21 -0.45 9.56e-15 Migraine;Coronary artery disease; CESC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg09877947 chr5:131593287 PDLIM4 -0.47 -6.08 -0.35 4.23e-9 Breast cancer; CESC cis rs12765878 1.000 rs9325507 chr10:105645622 C/T cg24587175 chr10:105670608 OBFC1 0.32 5.17 0.3 4.58e-7 Coronary artery disease; CESC cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg15556689 chr8:8085844 FLJ10661 0.43 5.49 0.32 9.41e-8 Mood instability; CESC cis rs6460942 0.591 rs7804805 chr7:12332066 C/G cg02935154 chr7:12443704 VWDE -0.53 -5.5 -0.32 9.01e-8 Coronary artery disease; CESC cis rs4268898 0.552 rs11125444 chr2:24367205 G/T cg20701182 chr2:24300061 SF3B14 -0.39 -5.47 -0.32 1.03e-7 Asthma; CESC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 7.5 0.42 9.57e-13 Total body bone mineral density; CESC trans rs60843830 1.000 rs2126129 chr2:212548 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 7.98 0.44 4.51e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9581857 0.556 rs9581864 chr13:28041567 T/C cg22138327 chr13:27999177 GTF3A 0.65 7.23 0.41 5.33e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs9612 1.000 rs346524 chr19:44260572 T/C cg08581076 chr19:44259116 C19orf61 0.52 6.19 0.36 2.33e-9 Exhaled nitric oxide output; CESC cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg00033643 chr7:134001901 SLC35B4 0.44 5.6 0.33 5.4e-8 Mean platelet volume; CESC cis rs7937682 0.824 rs577044 chr11:111490420 G/T cg09085632 chr11:111637200 PPP2R1B -0.92 -14.14 -0.66 3.34e-34 Primary sclerosing cholangitis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg21515243 chr18:21033072 RIOK3 -0.47 -6.49 -0.37 4.16e-10 Height; CESC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg16049864 chr8:95962084 TP53INP1 -0.72 -13.04 -0.63 2.36e-30 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22736280 chr8:95565249 KIAA1429 0.59 6.55 0.37 2.94e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06463913 chr11:207296 BET1L;RIC8A 0.51 6.03 0.35 5.35e-9 Gut microbiome composition (summer); CESC cis rs1364505 0.575 rs2341821 chr7:132014934 C/G cg03295361 chr7:131864608 PLXNA4 -0.38 -5.05 -0.3 8.22e-7 Venous thromboembolism (SNP x SNP interaction); CESC cis rs7267979 1.000 rs6050630 chr20:25430745 A/G cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.4e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7116495 1.000 rs949325 chr11:71729656 A/G cg10381502 chr11:71823885 C11orf51 -0.66 -5.61 -0.33 5.06e-8 Severe influenza A (H1N1) infection; CESC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.39 0.31 1.59e-7 Major depressive disorder; CESC cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg26597838 chr10:835615 NA 0.9 9.35 0.5 3.76e-18 Eosinophil percentage of granulocytes; CESC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.51 0.37 3.65e-10 Prudent dietary pattern; CESC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg12718519 chr1:2058417 PRKCZ 0.24 5.14 0.3 5.23e-7 Height; CESC cis rs79349575 0.721 rs1008834 chr17:46968008 G/C cg16584676 chr17:46985605 UBE2Z 0.54 6.6 0.38 2.2e-10 Type 2 diabetes; CESC cis rs698833 0.819 rs12053381 chr2:44570804 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.55 6.86 0.39 4.84e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg05340658 chr4:99064831 C4orf37 0.77 11.6 0.58 2.01e-25 Colonoscopy-negative controls vs population controls; CESC cis rs561341 1.000 rs483301 chr17:30293398 G/T cg19193384 chr17:30244184 NA -0.71 -6.6 -0.38 2.17e-10 Hip circumference adjusted for BMI; CESC cis rs3857067 0.806 rs7654919 chr4:95136164 C/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.15 -0.49 1.55e-17 QT interval; CESC cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08865097 chr6:119256162 MCM9 -0.49 -6.02 -0.35 5.91e-9 Ulcerative colitis; CESC cis rs6762477 0.505 rs17304079 chr3:50085153 A/G cg24110177 chr3:50126178 RBM5 -0.43 -5.06 -0.3 7.7300000000000005e-07 Menarche (age at onset); CESC cis rs9549260 0.709 rs12585870 chr13:41199487 A/C cg21288729 chr13:41239152 FOXO1 0.64 8.27 0.45 6.6e-15 Red blood cell count; CESC cis rs12477438 0.520 rs2964969 chr2:99782811 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.73 0.69 8.16e-40 Chronic sinus infection; CESC cis rs9303401 0.703 rs9909925 chr17:57210069 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.59 -7.82 -0.43 1.28e-13 Cognitive test performance; CESC cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg06713675 chr4:122721982 EXOSC9 -0.43 -5.99 -0.35 6.69e-9 Type 2 diabetes; CESC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg07701084 chr6:150067640 NUP43 0.43 6.0 0.35 6.52e-9 Lung cancer; CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg21548813 chr6:291882 DUSP22 0.74 10.14 0.53 1.21e-20 Menopause (age at onset); CESC cis rs6460942 0.597 rs4721107 chr7:12535105 T/G cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC trans rs2727020 0.658 rs7120136 chr11:49384358 A/C cg03929089 chr4:120376271 NA -0.81 -12.68 -0.61 4.19e-29 Coronary artery disease; CESC cis rs6714710 0.580 rs55886305 chr2:98495661 T/G cg26665480 chr2:98280029 ACTR1B 0.56 7.86 0.43 9.67e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.35 0.6 5.48e-28 Personality dimensions; CESC cis rs1044826 0.642 rs295482 chr3:139229264 A/T cg00490450 chr3:139108681 COPB2 -0.44 -5.43 -0.32 1.31e-7 Obesity-related traits; CESC trans rs2832077 0.527 rs2738953 chr21:30238363 G/C cg14791747 chr16:20752902 THUMPD1 -0.47 -6.56 -0.37 2.78e-10 Cognitive test performance; CESC cis rs654950 1.000 rs600401 chr1:41984658 C/T cg06885757 chr1:42089581 HIVEP3 0.47 7.42 0.41 1.6e-12 Airway imaging phenotypes; CESC trans rs79976124 0.837 rs75346757 chr6:66648386 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 8.71 0.47 3.31e-16 Type 2 diabetes; CESC trans rs9325144 0.555 rs2387843 chr12:38711203 T/C cg23762105 chr12:34175262 ALG10 -0.49 -6.51 -0.37 3.8e-10 Morning vs. evening chronotype; CESC cis rs9486719 0.690 rs2092094 chr6:96844123 G/C cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC cis rs12042938 0.507 rs1765777 chr1:231731742 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.53 -0.46 1.16e-15 Neuranatomic and neurocognitive phenotypes; CESC cis rs4253772 0.626 rs9615960 chr22:46752307 G/A cg18190219 chr22:46762943 CELSR1 -0.73 -6.33 -0.36 1.01e-9 LDL cholesterol;Cholesterol, total; CESC cis rs62005083 1.000 rs62006777 chr14:74635749 T/G cg05179529 chr14:74551516 LIN52;ALDH6A1 0.64 5.38 0.31 1.63e-7 Mean corpuscular volume; CESC cis rs1006703 0.544 rs55673593 chr17:3834179 T/C cg06463185 chr17:3833770 ATP2A3 -0.56 -6.01 -0.35 6.17e-9 Glucose homeostasis traits; CESC cis rs11785400 0.793 rs13255558 chr8:143748080 C/T cg24634471 chr8:143751801 JRK 0.46 5.71 0.33 3.03e-8 Schizophrenia; CESC cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg11752832 chr7:134001865 SLC35B4 0.54 6.98 0.39 2.33e-11 Mean platelet volume; CESC cis rs793571 0.590 rs673813 chr15:59077171 A/T cg05156742 chr15:59063176 FAM63B 0.63 8.19 0.45 1.08e-14 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07257649 chr6:4776641 CDYL -0.48 -6.13 -0.35 3.21e-9 Ulcerative colitis; CESC trans rs7827545 0.545 rs6988000 chr8:135559534 C/T cg24633756 chr6:26577808 NA -0.53 -6.17 -0.35 2.52e-9 Hypertension (SNP x SNP interaction); CESC cis rs453301 0.686 rs11785634 chr8:8892597 G/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.0 -0.35 6.54e-9 Joint mobility (Beighton score); CESC cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg10556349 chr10:835070 NA 0.59 5.59 0.32 5.54e-8 Eosinophil percentage of granulocytes; CESC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC cis rs7474896 0.609 rs1830612 chr10:37999883 A/G cg00409905 chr10:38381863 ZNF37A -0.44 -5.08 -0.3 6.97e-7 Obesity (extreme); CESC cis rs73206853 0.764 rs7953794 chr12:111081197 A/G cg12870014 chr12:110450643 ANKRD13A 0.66 5.94 0.34 8.88e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg20307385 chr11:47447363 PSMC3 -0.52 -6.1 -0.35 3.66e-9 Subjective well-being; CESC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg04518342 chr5:131593106 PDLIM4 0.42 6.42 0.37 6.39e-10 Acylcarnitine levels; CESC cis rs2486288 0.656 rs11629807 chr15:45547037 T/C cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 2.96e-10 Glomerular filtration rate; CESC cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg22431228 chr1:16359049 CLCNKA -0.47 -7.82 -0.43 1.22e-13 Dilated cardiomyopathy; CESC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg21963583 chr11:68658836 MRPL21 0.38 5.47 0.32 1.03e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs27434 0.605 rs39840 chr5:96120054 G/C cg16492584 chr5:96139282 ERAP1 -0.5 -5.97 -0.34 7.61e-9 Ankylosing spondylitis; CESC cis rs708547 0.647 rs4864609 chr4:57878141 T/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.47 6.61 0.38 2.11e-10 Response to bleomycin (chromatid breaks); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03988161 chr6:122720663 HSF2 -0.49 -6.4 -0.37 7.01e-10 Ulcerative colitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12032620 chr15:43802735 TP53BP1 -0.43 -6.06 -0.35 4.68e-9 Gut microbiota (bacterial taxa); CESC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg05132306 chr1:1846340 CALML6 -0.3 -6.3 -0.36 1.26e-9 Body mass index; CESC cis rs10751667 1.000 rs7396798 chr11:970510 G/T cg06064525 chr11:970664 AP2A2 -0.37 -6.55 -0.37 2.92e-10 Alzheimer's disease (late onset); CESC cis rs7551222 0.752 rs6594016 chr1:204539462 G/A cg20240347 chr1:204465584 NA -0.28 -5.64 -0.33 4.38e-8 Schizophrenia; CESC cis rs7539624 0.898 rs7554857 chr1:223891552 T/C cg10100437 chr1:223903862 CAPN2 -0.41 -6.02 -0.35 5.77e-9 Schizophrenia; CESC cis rs4664304 0.903 rs72957576 chr2:160754132 A/C cg03641300 chr2:160917029 PLA2R1 -0.48 -6.85 -0.39 5.03e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs17253792 0.822 rs74412558 chr14:56054311 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.66 0.33 3.95e-8 Putamen volume; CESC cis rs6088580 0.602 rs6058064 chr20:33086622 A/G cg24642439 chr20:33292090 TP53INP2 0.5 6.59 0.38 2.42e-10 Glomerular filtration rate (creatinine); CESC cis rs1372520 0.684 rs356188 chr4:90691537 T/C cg15133208 chr4:90757351 SNCA 0.4 5.17 0.3 4.51e-7 Neuroticism; CESC cis rs10927875 0.632 rs6677321 chr1:16149301 A/C cg05821634 chr1:16164109 FLJ37453 0.35 5.04 0.3 8.7e-7 Dilated cardiomyopathy; CESC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg18225595 chr11:63971243 STIP1 -0.5 -5.11 -0.3 6.24e-7 Mean platelet volume; CESC cis rs9837602 1.000 rs62285462 chr3:99769834 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.51 7.29 0.41 3.59e-12 Breast cancer; CESC cis rs2463822 0.858 rs2513077 chr11:62105925 A/G cg06239285 chr11:62104954 ASRGL1 -0.86 -8.85 -0.48 1.27e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17543123 chr19:30155994 PLEKHF1 -0.6 -7.2 -0.4 6.13e-12 Gut microbiome composition (summer); CESC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg16545954 chr1:2118288 C1orf86 0.36 7.02 0.4 1.81e-11 Height; CESC cis rs6942756 0.713 rs692597 chr7:129132554 T/G cg02491457 chr7:128862824 NA -0.55 -7.69 -0.43 2.86e-13 White matter hyperintensity burden; CESC cis rs12500824 0.564 rs116609504 chr4:77315062 C/A cg20311846 chr4:77356250 SHROOM3 0.38 7.35 0.41 2.4e-12 Coronary artery disease; CESC cis rs9287719 0.967 rs6721739 chr2:10751246 G/T cg02196655 chr2:10830764 NOL10 0.35 5.27 0.31 2.79e-7 Prostate cancer; CESC cis rs1023500 0.551 rs133371 chr22:42465574 G/A cg04733989 chr22:42467013 NAGA 0.79 12.05 0.59 5.98e-27 Schizophrenia; CESC cis rs8077577 0.895 rs16960990 chr17:18108601 A/G cg16794390 chr17:18148240 FLII 0.41 5.77 0.33 2.23e-8 Obesity-related traits; CESC cis rs6815814 0.950 rs73236615 chr4:38786869 G/T cg02016764 chr4:38805732 TLR1 -0.64 -7.93 -0.44 6.35e-14 Breast cancer; CESC trans rs4596713 0.507 rs9314865 chr9:71801495 A/G cg16512924 chr15:28394682 HERC2 0.48 6.11 0.35 3.47e-9 Headache; CESC cis rs694739 0.595 rs11606015 chr11:64136877 C/G cg23796481 chr11:64053134 BAD;GPR137 0.58 7.09 0.4 1.23e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs9733 0.744 rs2089081 chr1:150800117 T/C cg13175981 chr1:150552382 MCL1 0.5 6.98 0.39 2.34e-11 Tonsillectomy; CESC cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg22834771 chr12:69754056 YEATS4 -0.48 -6.38 -0.37 7.7e-10 Blood protein levels; CESC cis rs11577318 0.853 rs7416513 chr1:26647949 G/C cg00813993 chr1:26644493 UBXN11;CD52 -0.39 -6.26 -0.36 1.51e-9 Granulocyte percentage of myeloid white cells; CESC cis rs9612 0.718 rs346531 chr19:44239927 T/C cg08581076 chr19:44259116 C19orf61 0.42 5.08 0.3 7.05e-7 Exhaled nitric oxide output; CESC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg05313129 chr8:58192883 C8orf71 -0.54 -6.27 -0.36 1.48e-9 Developmental language disorder (linguistic errors); CESC cis rs7123876 0.553 rs10898868 chr11:72431679 A/G cg03713592 chr11:72463424 ARAP1 0.53 6.22 0.36 1.93e-9 Body mass index; CESC cis rs559928 0.597 rs11600667 chr11:63976183 C/T cg18225595 chr11:63971243 STIP1 0.65 5.71 0.33 2.95e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs763121 0.853 rs5757234 chr22:39072686 C/T cg06544989 chr22:39130855 UNC84B 0.52 9.99 0.52 3.63e-20 Menopause (age at onset); CESC cis rs739401 0.611 rs391188 chr11:3047634 G/A cg08508325 chr11:3079039 CARS -0.51 -9.99 -0.52 3.69e-20 Longevity; CESC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.5 0.42 9.36e-13 Prudent dietary pattern; CESC cis rs6088590 0.687 rs6088582 chr20:33286798 G/A cg08999081 chr20:33150536 PIGU 0.65 10.69 0.55 1.99e-22 Coronary artery disease; CESC cis rs61935443 0.673 rs11107770 chr12:95275147 C/T cg21533806 chr12:95267307 NA -0.57 -7.04 -0.4 1.62e-11 Schizophrenia; CESC cis rs6032067 0.929 rs2868238 chr20:43826993 C/G cg11264863 chr20:43835661 SEMG1 0.49 5.29 0.31 2.5e-7 Blood protein levels; CESC cis rs677665 0.537 rs6688233 chr1:9335745 A/G cg25755851 chr1:9335794 NA -0.97 -14.38 -0.66 4.88e-35 Eosinophil percentage of white cells; CESC cis rs10489202 0.632 rs202273 chr1:167919963 A/G cg24449463 chr1:168025552 DCAF6 -0.46 -6.2 -0.36 2.1e-9 Schizophrenia; CESC cis rs367615 0.918 rs10051855 chr5:108859958 G/A cg17395555 chr5:108820864 NA 0.55 8.19 0.45 1.13e-14 Colorectal cancer (SNP x SNP interaction); CESC trans rs5756813 0.782 rs3171656 chr22:38172213 G/A cg19894588 chr14:64061835 NA -0.7 -8.74 -0.47 2.75e-16 Optic cup area;Vertical cup-disc ratio; CESC cis rs4808199 0.895 rs4808196 chr19:19476520 G/A cg03709012 chr19:19516395 GATAD2A 1.14 13.02 0.62 2.66e-30 Nonalcoholic fatty liver disease; CESC cis rs829880 0.858 rs733180 chr12:98842588 C/T cg25150519 chr12:98850993 NA 0.8 11.83 0.59 3.36e-26 Colonoscopy-negative controls vs population controls; CESC cis rs7772486 0.790 rs2247666 chr6:146220409 C/A cg23711669 chr6:146136114 FBXO30 0.94 13.73 0.64 9.31e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs1568889 1.000 rs11826837 chr11:28322566 C/G cg06544937 chr11:28130018 METT5D1;KIF18A -0.75 -10.69 -0.55 2.02e-22 Bipolar disorder; CESC cis rs2996428 0.561 rs2275833 chr1:3745721 C/T cg13057898 chr1:3703894 LRRC47 0.38 5.64 0.33 4.37e-8 Red cell distribution width; CESC trans rs10776614 0.799 rs1445148 chr10:49763709 T/A cg19218067 chr2:181235115 NA 0.5 6.1 0.35 3.7e-9 Self-employment; CESC cis rs11711311 1.000 rs7622403 chr3:113472434 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.7 -9.94 -0.52 5.6e-20 IgG glycosylation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10345337 chr14:65569751 MAX -0.46 -6.48 -0.37 4.47e-10 Gut microbiota (bacterial taxa); CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg09033563 chr22:24373618 LOC391322 0.52 7.05 0.4 1.52e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg23172400 chr8:95962367 TP53INP1 -0.47 -9.92 -0.52 6.36e-20 Type 2 diabetes; CESC cis rs12940923 0.655 rs2526372 chr17:56440526 G/A cg12560992 chr17:57184187 TRIM37 0.64 5.64 0.33 4.42e-8 Circulating myeloperoxidase levels (plasma); CESC cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.93 9.06 0.49 2.99e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7903847 0.642 rs2297668 chr10:99160046 C/T cg20016023 chr10:99160130 RRP12 -0.3 -5.2 -0.3 4.02e-7 Granulocyte percentage of myeloid white cells; CESC cis rs4972806 0.849 rs1542180 chr2:177028767 C/T cg14324370 chr2:177042789 NA 0.43 6.14 0.35 3.05e-9 IgG glycosylation; CESC cis rs9487051 0.652 rs13210424 chr6:109598737 G/A cg21918786 chr6:109611834 NA -0.37 -5.53 -0.32 7.81e-8 Reticulocyte fraction of red cells; CESC cis rs7100689 0.646 rs9420370 chr10:82073248 C/T cg00277334 chr10:82204260 NA -0.61 -8.08 -0.44 2.26e-14 Post bronchodilator FEV1; CESC cis rs478304 0.651 rs11600918 chr11:65511965 A/G cg27068330 chr11:65405492 SIPA1 -0.45 -5.45 -0.32 1.15e-7 Acne (severe); CESC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg19163074 chr7:65112434 INTS4L2 0.4 5.16 0.3 4.86e-7 Aortic root size; CESC cis rs3126085 0.935 rs6587647 chr1:152192631 C/T cg26876637 chr1:152193138 HRNR 0.48 5.5 0.32 8.93e-8 Atopic dermatitis; CESC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg26839252 chr6:160211577 TCP1;MRPL18 0.47 5.38 0.31 1.61e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs6430585 0.583 rs730005 chr2:136582694 T/C cg07169764 chr2:136633963 MCM6 1.35 20.15 0.78 2.09e-55 Corneal structure; CESC cis rs3096299 0.617 rs2353030 chr16:89405827 C/T cg16743903 chr16:89593216 SPG7 0.41 5.09 0.3 6.9e-7 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14104172 chr9:79074807 GCNT1 -0.58 -6.67 -0.38 1.48e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.26e-11 Skin colour saturation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25367318 chr6:138725211 HEBP2 -0.42 -6.19 -0.36 2.27e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19969113 chr12:118810441 TAOK3 0.58 6.77 0.38 8.29e-11 Gut microbiome composition (summer); CESC cis rs4718428 0.705 rs28648401 chr7:66367132 T/C cg12165864 chr7:66369176 NA -0.67 -7.74 -0.43 2.09e-13 Corneal structure; CESC cis rs4148883 0.504 rs4147544 chr4:100134514 G/T cg13256891 chr4:100009986 ADH5 -0.49 -6.3 -0.36 1.22e-9 Alcohol dependence; CESC cis rs61931739 0.500 rs7484658 chr12:34515879 A/G cg06521331 chr12:34319734 NA -0.37 -5.09 -0.3 6.85e-7 Morning vs. evening chronotype; CESC cis rs9291683 0.575 rs3756223 chr4:10105797 C/T cg00071950 chr4:10020882 SLC2A9 0.58 8.69 0.47 3.84e-16 Bone mineral density; CESC cis rs1832871 0.711 rs7770047 chr6:158685696 A/G cg07165851 chr6:158734300 TULP4 0.59 6.23 0.36 1.87e-9 Height; CESC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg07701084 chr6:150067640 NUP43 0.47 6.54 0.37 3.07e-10 Lung cancer; CESC cis rs2228479 0.618 rs17233623 chr16:89811209 C/T cg06558623 chr16:89946397 TCF25 0.93 8.15 0.45 1.47e-14 Skin colour saturation; CESC cis rs4523957 0.583 rs7225168 chr17:2023089 T/G cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg09323728 chr8:95962352 TP53INP1 -0.41 -8.95 -0.48 6.25e-17 Type 2 diabetes; CESC cis rs9911578 1.000 rs302840 chr17:56673079 C/G cg12560992 chr17:57184187 TRIM37 0.93 15.48 0.69 6.05e-39 Intelligence (multi-trait analysis); CESC cis rs1005277 0.522 rs289647 chr10:37968278 A/G cg00409905 chr10:38381863 ZNF37A -0.47 -6.6 -0.38 2.27e-10 Extrinsic epigenetic age acceleration; CESC cis rs7084402 0.935 rs12264028 chr10:60278140 C/T cg07615347 chr10:60278583 BICC1 -0.58 -9.25 -0.49 7.59e-18 Refractive error; CESC cis rs854765 0.547 rs9913277 chr17:17919749 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.53 7.4 0.41 1.77e-12 Total body bone mineral density; CESC cis rs763014 0.931 rs3752567 chr16:628130 A/G cg00908189 chr16:619842 PIGQ 0.66 9.17 0.49 1.34e-17 Height; CESC cis rs9916302 0.821 rs4795386 chr17:37746847 A/G cg07936489 chr17:37558343 FBXL20 -0.76 -10.13 -0.53 1.32e-20 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22752895 chr6:3118674 BPHL 0.68 7.67 0.43 3.26e-13 Gut microbiome composition (summer); CESC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg07507251 chr3:52567010 NT5DC2 -0.32 -5.3 -0.31 2.5e-7 Bipolar disorder; CESC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg02034447 chr16:89574710 SPG7 0.5 6.48 0.37 4.52e-10 Multiple myeloma (IgH translocation); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12317515 chr5:74063363 GFM2;NSA2 -0.47 -6.45 -0.37 5.33e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg16743903 chr16:89593216 SPG7 -0.43 -5.49 -0.32 9.57e-8 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08537418 chr17:5342414 C1QBP 0.58 6.51 0.37 3.68e-10 Gut microbiome composition (summer); CESC cis rs7590368 0.651 rs56093996 chr2:10931302 T/C cg15705551 chr2:10952987 PDIA6 0.55 5.29 0.31 2.52e-7 Educational attainment (years of education); CESC cis rs1008375 0.966 rs3733581 chr4:17695206 C/G cg27347728 chr4:17578864 LAP3 -0.46 -5.35 -0.31 1.93e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6051080 1 rs6051080 chr20:25975674 A/G cg21995068 chr20:25989032 LOC100134868 -0.35 -5.91 -0.34 1.05e-8 Colorectal or endometrial cancer; CESC cis rs9926296 0.581 rs12598477 chr16:89902482 T/C cg04287289 chr16:89883240 FANCA 0.67 8.73 0.47 2.95e-16 Vitiligo; CESC cis rs1348850 0.645 rs7571386 chr2:178442687 A/C cg23306229 chr2:178417860 TTC30B 0.67 7.13 0.4 9.75e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs208520 0.754 rs7753158 chr6:66875633 A/C cg07460842 chr6:66804631 NA -0.92 -11.54 -0.58 3.16e-25 Exhaled nitric oxide output; CESC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg21782813 chr7:2030301 MAD1L1 0.49 6.96 0.39 2.66e-11 Bipolar disorder and schizophrenia; CESC cis rs4803468 0.967 rs4803461 chr19:41908871 G/A cg09537434 chr19:41945824 ATP5SL -1.01 -17.89 -0.74 1.82e-47 Height; CESC cis rs738322 0.775 rs13056506 chr22:38580917 G/T cg25457927 chr22:38595422 NA 0.33 6.17 0.35 2.49e-9 Cutaneous nevi; CESC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg22029157 chr1:209979665 IRF6 0.75 10.6 0.55 4.22e-22 Cleft lip with or without cleft palate; CESC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg16405210 chr4:1374714 KIAA1530 0.97 13.85 0.65 3.45e-33 Longevity; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22352186 chr4:1722180 TMEM129;TACC3 -0.44 -6.31 -0.36 1.16e-9 Gambling; CESC cis rs17039065 0.920 rs11097990 chr4:109432223 T/C cg16022748 chr4:109541635 LOC285456;RPL34 0.61 5.16 0.3 4.75e-7 Gut microbiome composition (summer); CESC cis rs5753618 0.583 rs738657 chr22:31841749 T/A cg00478049 chr22:31556069 RNF185 -0.43 -5.26 -0.31 2.94e-7 Colorectal cancer; CESC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg11644478 chr21:40555479 PSMG1 -0.79 -11.71 -0.58 8.23e-26 Cognitive function; CESC cis rs3857536 0.740 rs7769722 chr6:66891363 C/T cg07460842 chr6:66804631 NA -0.4 -5.23 -0.31 3.47e-7 Blood trace element (Cu levels); CESC trans rs17132261 0.661 rs12521859 chr5:109671958 C/G cg14311597 chr17:2652531 MIR1253 -0.51 -6.06 -0.35 4.64e-9 Cardiac structure and function;Left ventricle wall thickness; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg06549955 chr12:110434341 GIT2 -0.54 -6.67 -0.38 1.49e-10 Gut microbiota (bacterial taxa); CESC cis rs763014 0.931 rs11648728 chr16:635525 C/T cg00908189 chr16:619842 PIGQ 0.65 9.02 0.48 4.04e-17 Height; CESC cis rs2797501 0.615 rs2797493 chr10:5794025 C/T cg11519256 chr10:5708881 ASB13 0.5 5.05 0.3 8.14e-7 Osteosarcoma; CESC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg22963979 chr7:1858916 MAD1L1 -0.4 -5.5 -0.32 8.82e-8 Bipolar disorder and schizophrenia; CESC cis rs6690583 0.562 rs12024977 chr1:85531051 A/C cg22488158 chr1:85528044 WDR63 0.53 5.24 0.31 3.28e-7 Serum sulfate level; CESC cis rs7772486 0.686 rs2092263 chr6:146029687 G/A cg05347473 chr6:146136440 FBXO30 -0.52 -6.93 -0.39 3.22e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1707322 0.685 rs6690926 chr1:46134978 T/C cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9487051 0.735 rs459956 chr6:109524760 A/G cg01475377 chr6:109611718 NA -0.46 -6.92 -0.39 3.45e-11 Reticulocyte fraction of red cells; CESC trans rs2823962 0.759 rs2823929 chr21:18014226 C/G cg06419850 chr17:4688683 VMO1 0.44 6.47 0.37 4.59e-10 Amyotrophic lateral sclerosis; CESC cis rs4132509 1.000 rs10927051 chr1:243805936 G/C cg21452805 chr1:244014465 NA 0.44 5.31 0.31 2.29e-7 RR interval (heart rate); CESC cis rs11098499 0.863 rs1383533 chr4:120434576 G/A cg09307838 chr4:120376055 NA 0.93 12.75 0.62 2.41e-29 Corneal astigmatism; CESC cis rs7662987 0.517 rs1453873 chr4:100022571 T/C cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.21e-14 Smoking initiation; CESC cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg18198730 chr1:247681584 NA 0.59 7.81 0.43 1.32e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs17023223 0.537 rs12097967 chr1:119702913 A/G cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs12681288 0.862 rs2004701 chr8:1022287 A/G cg15309053 chr8:964076 NA 0.34 5.73 0.33 2.78e-8 Schizophrenia; CESC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg18230493 chr5:56204884 C5orf35 -0.75 -8.97 -0.48 5.46e-17 Initial pursuit acceleration; CESC cis rs6032067 0.777 rs17332620 chr20:43777506 C/T cg10761708 chr20:43804764 PI3 0.54 6.45 0.37 5.33e-10 Blood protein levels; CESC cis rs72781680 0.611 rs4149373 chr2:24300023 C/T cg06627628 chr2:24431161 ITSN2 -0.67 -6.5 -0.37 4.03e-10 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17589437 chr7:87563717 ADAM22 0.58 6.98 0.39 2.37e-11 Gut microbiome composition (summer); CESC cis rs6835098 0.961 rs17322893 chr4:174122556 A/G cg08422745 chr4:174089978 GALNT7 0.72 9.27 0.49 6.92e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs524023 0.874 rs506338 chr11:64440920 T/C cg19131476 chr11:64387923 NRXN2 -0.32 -5.05 -0.3 8.11e-7 Urate levels in obese individuals; CESC cis rs1355223 1.000 rs11604069 chr11:34764251 A/G cg11058730 chr11:34937778 PDHX;APIP -0.49 -6.36 -0.36 9e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.26 0.31 2.99e-7 Colonoscopy-negative controls vs population controls; CESC trans rs12310956 0.515 rs1872745 chr12:33985987 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.64 0.38 1.82e-10 Morning vs. evening chronotype; CESC cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg04455712 chr21:45112962 RRP1B 0.36 5.21 0.3 3.79e-7 Mean corpuscular volume; CESC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg03351412 chr1:154909251 PMVK 0.68 9.09 0.49 2.43e-17 Prostate cancer; CESC trans rs17685 0.753 rs10251863 chr7:75790192 T/C cg19862616 chr7:65841803 NCRNA00174 0.84 12.03 0.59 6.77e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg11890956 chr21:40555474 PSMG1 1.17 22.42 0.81 3.65e-63 Cognitive function; CESC cis rs6547741 1.000 rs1528402 chr2:27857517 G/A cg21248554 chr2:27665150 KRTCAP3 0.25 5.3 0.31 2.42e-7 Oral cavity cancer; CESC trans rs7615952 0.599 rs12486459 chr3:125741465 T/G cg07211511 chr3:129823064 LOC729375 -0.59 -6.62 -0.38 2e-10 Blood pressure (smoking interaction); CESC cis rs208520 1.000 rs12216109 chr6:66987488 C/G cg07460842 chr6:66804631 NA 0.88 10.12 0.53 1.49e-20 Exhaled nitric oxide output; CESC cis rs7312774 0.618 rs9651926 chr12:107356820 G/A cg16260113 chr12:107380972 MTERFD3 0.85 7.24 0.41 4.9e-12 Severe influenza A (H1N1) infection; CESC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg08736216 chr1:53307985 ZYG11A 0.43 7.16 0.4 7.71e-12 Monocyte count; CESC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg23758822 chr17:41437982 NA 1.03 14.75 0.67 2.37e-36 Menopause (age at onset); CESC cis rs2953145 0.545 rs2975755 chr2:241524919 G/A cg07929629 chr2:241523174 NA 0.65 8.96 0.48 6.08e-17 Bipolar disorder; CESC cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg07697082 chr8:82753677 SNX16 0.37 5.15 0.3 5.13e-7 Diastolic blood pressure; CESC cis rs616402 0.527 rs604369 chr1:10567208 C/A cg07384165 chr1:10488281 NA -0.58 -8.63 -0.47 5.96e-16 Breast size; CESC cis rs863345 0.604 rs7525362 chr1:158493890 G/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.75e-11 Pneumococcal bacteremia; CESC cis rs72945132 0.882 rs6592552 chr11:70223831 A/T cg14191688 chr11:70257035 CTTN 0.4 5.13 0.3 5.7e-7 Coronary artery disease; CESC cis rs8028182 0.636 rs12708520 chr15:75830539 C/T cg20655648 chr15:75932815 IMP3 0.48 6.02 0.35 5.64e-9 Sudden cardiac arrest; CESC cis rs4604732 0.536 rs7528219 chr1:247628307 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.53 6.57 0.37 2.7e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs826838 1.000 rs10880914 chr12:38720543 C/T cg26384229 chr12:38710491 ALG10B 0.83 14.87 0.67 9.19e-37 Heart rate; CESC cis rs4268898 0.662 rs72795824 chr2:24435837 T/C cg20701182 chr2:24300061 SF3B14 0.68 7.16 0.4 7.75e-12 Asthma; CESC cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg14061069 chr19:46274453 DMPK -0.4 -5.48 -0.32 9.81e-8 Coronary artery disease; CESC trans rs10411161 0.752 rs4584941 chr19:52392141 C/T cg22319618 chr22:45562946 NUP50 -0.8 -8.04 -0.44 2.96e-14 Breast cancer; CESC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg18876405 chr7:65276391 NA 0.54 7.27 0.41 4.04e-12 Aortic root size; CESC cis rs7772486 0.776 rs2265467 chr6:146218339 T/A cg05347473 chr6:146136440 FBXO30 0.49 6.45 0.37 5.3e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23506944 chr17:28257236 EFCAB5;SSH2 0.52 6.09 0.35 3.89e-9 Gut microbiome composition (summer); CESC cis rs16854884 0.632 rs1910691 chr3:143656905 G/A cg01302019 chr3:143689584 C3orf58 -0.34 -5.18 -0.3 4.45e-7 Economic and political preferences (feminism/equality); CESC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg24549020 chr5:56110836 MAP3K1 0.68 7.71 0.43 2.61e-13 Initial pursuit acceleration; CESC cis rs9457247 0.602 rs6456152 chr6:167472062 A/G cg07741184 chr6:167504864 NA 0.38 6.7 0.38 1.22e-10 Crohn's disease; CESC cis rs7208859 0.623 rs9912283 chr17:29110373 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg18196295 chr10:418757 DIP2C -0.42 -5.54 -0.32 7.3e-8 Psychosis in Alzheimer's disease; CESC cis rs9616064 0.557 rs5767318 chr22:47048792 A/G cg25730555 chr22:47059586 GRAMD4 0.46 5.73 0.33 2.71e-8 Urate levels in obese individuals; CESC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg13114125 chr14:105738426 BRF1 -0.75 -9.32 -0.5 4.64e-18 Mean platelet volume;Platelet distribution width; CESC trans rs7246657 0.943 rs7255407 chr19:37933936 G/A cg24637308 chr11:6592297 DNHD1 0.54 6.34 0.36 1.01e-9 Coronary artery calcification; CESC cis rs3925075 1.000 rs3925075 chr16:31347748 C/T cg02846316 chr16:31340340 ITGAM -0.4 -6.35 -0.36 9.23e-10 IgA nephropathy; CESC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg06873352 chr17:61820015 STRADA 0.72 12.7 0.62 3.41e-29 Prudent dietary pattern; CESC cis rs9302690 0.557 rs223869 chr16:57494992 C/A cg27017172 chr16:57497170 POLR2C 0.64 5.52 0.32 8.22e-8 Blood protein levels; CESC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.87 0.39 4.55e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4746818 1.000 rs7091695 chr10:70964997 A/G cg04149295 chr10:70884716 VPS26A -0.6 -5.29 -0.31 2.55e-7 Left atrial antero-posterior diameter; CESC cis rs1707322 0.716 rs10890342 chr1:46157087 C/T cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg27121462 chr16:89883253 FANCA -0.45 -5.21 -0.3 3.8e-7 Vitiligo; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04062965 chr2:219188029 PNKD -0.55 -7.03 -0.4 1.73e-11 Asthma; CESC cis rs4727027 0.704 rs12704071 chr7:148904795 C/T cg23583168 chr7:148888333 NA -0.86 -14.32 -0.66 8.03e-35 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs853679 0.882 rs9380069 chr6:28203300 A/G cg18032046 chr6:28092343 ZSCAN16 -0.71 -6.59 -0.38 2.37e-10 Depression; CESC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs6694270 0.529 rs4076925 chr1:19113026 C/T cg26220594 chr1:19110978 NA 0.4 5.39 0.31 1.52e-7 Drug-induced liver injury (nitrofurantoin); CESC cis rs11785400 0.793 rs2976400 chr8:143743611 G/A cg24634471 chr8:143751801 JRK 0.43 5.48 0.32 9.95e-8 Schizophrenia; CESC cis rs1865760 0.588 rs9467658 chr6:26010881 T/G cg16482183 chr6:26056742 HIST1H1C 0.4 5.64 0.33 4.42e-8 Height; CESC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg13798912 chr7:905769 UNC84A 0.52 5.11 0.3 6.23e-7 Cerebrospinal P-tau181p levels; CESC cis rs1707322 0.721 rs11211149 chr1:46112218 T/C cg06784218 chr1:46089804 CCDC17 0.4 7.04 0.4 1.69e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4523957 0.533 rs216216 chr17:2145046 A/G cg16513277 chr17:2031491 SMG6 0.5 5.35 0.31 1.94e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs6479874 1.000 rs7080757 chr10:52759553 T/G cg14115756 chr9:125795935 GPR21;RABGAP1 0.68 6.0 0.35 6.41e-9 Migraine; CESC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg21984481 chr17:79567631 NPLOC4 -0.49 -8.04 -0.44 2.97e-14 Eye color traits; CESC cis rs7267979 1.000 rs2258066 chr20:25271326 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.62 0.75 4.72e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs2120019 1.000 rs7168680 chr15:75369212 G/A cg09165964 chr15:75287851 SCAMP5 -0.66 -7.96 -0.44 5.22e-14 Blood trace element (Zn levels); CESC cis rs6460942 0.524 rs6948366 chr7:12369905 A/G cg02935154 chr7:12443704 VWDE -0.45 -5.95 -0.34 8.54e-9 Coronary artery disease; CESC cis rs3617 0.625 rs2239548 chr3:52854186 A/C cg07507251 chr3:52567010 NT5DC2 0.34 5.88 0.34 1.2e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs3092073 0.603 rs4810477 chr20:44544654 C/T cg27529037 chr20:44575021 PCIF1 0.64 9.5 0.5 1.32e-18 Intelligence (multi-trait analysis); CESC cis rs6089584 0.627 rs55875402 chr20:60559925 G/A cg24733560 chr20:60626293 TAF4 0.42 6.29 0.36 1.33e-9 Body mass index; CESC cis rs7772486 0.875 rs9403765 chr6:146368041 C/T cg23711669 chr6:146136114 FBXO30 -0.81 -11.32 -0.57 1.76e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg03609598 chr5:56110824 MAP3K1 -0.53 -5.57 -0.32 6.1e-8 Initial pursuit acceleration; CESC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg05368731 chr17:41323189 NBR1 0.79 11.1 0.56 8.99e-24 Menopause (age at onset); CESC cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg10578991 chr7:12443926 VWDE -0.51 -5.67 -0.33 3.75e-8 Coronary artery disease; CESC cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg23711669 chr6:146136114 FBXO30 -1.01 -15.7 -0.69 1.03e-39 Lobe attachment (rater-scored or self-reported); CESC trans rs1838239 0.908 rs7898983 chr10:4692213 T/C cg24270710 chr12:132930766 NA 0.57 6.13 0.35 3.24e-9 Major depressive disorder; CESC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg00129232 chr17:37814104 STARD3 0.54 6.9 0.39 3.73e-11 Glomerular filtration rate (creatinine); CESC cis rs698833 0.828 rs2850298 chr2:44731590 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.77 0.33 2.24e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs3008870 1.000 rs1925412 chr1:67405057 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.04 14.53 0.67 1.38e-35 Lymphocyte percentage of white cells; CESC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.18 0.3 4.5e-7 Menopause (age at onset); CESC cis rs1153858 1.000 rs2467864 chr15:45641098 C/T cg21132104 chr15:45694354 SPATA5L1 -0.77 -10.2 -0.53 8.3e-21 Homoarginine levels; CESC cis rs7246657 0.943 rs7257672 chr19:37823859 G/C cg23950597 chr19:37808831 NA -0.55 -6.04 -0.35 5.24e-9 Coronary artery calcification; CESC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg06456125 chr7:65229604 NA -0.43 -5.43 -0.32 1.25e-7 Aortic root size; CESC cis rs3857067 1.000 rs7682116 chr4:95002704 T/C cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3e-14 QT interval; CESC cis rs2439831 0.867 rs2255042 chr15:43834318 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.82 -9.18 -0.49 1.26e-17 Lung cancer in ever smokers; CESC cis rs1976403 0.633 rs1697422 chr1:21821897 T/C cg21906605 chr1:21766650 NBPF3 0.4 5.19 0.3 4.18e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs4594175 0.707 rs12432912 chr14:51739395 T/C cg23942311 chr14:51606299 NA 0.37 5.61 0.33 5.05e-8 Cancer; CESC trans rs7980799 0.682 rs1601005 chr12:33634658 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.23 -0.45 8.55e-15 Heart rate;Heart rate variability traits (RMSSD); CESC trans rs11098499 0.874 rs6826823 chr4:120112098 G/C cg25214090 chr10:38739885 LOC399744 0.58 7.71 0.43 2.54e-13 Corneal astigmatism; CESC cis rs7208859 0.573 rs7223803 chr17:29077193 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg02487422 chr3:49467188 NICN1 0.39 5.05 0.3 8.06e-7 Parkinson's disease; CESC cis rs7927592 0.913 rs11228287 chr11:68349754 A/G cg20283391 chr11:68216788 NA -0.61 -7.29 -0.41 3.48e-12 Total body bone mineral density; CESC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg16545954 chr1:2118288 C1orf86 -0.33 -6.15 -0.35 2.83e-9 Height; CESC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg05313129 chr8:58192883 C8orf71 -0.49 -5.35 -0.31 1.88e-7 Developmental language disorder (linguistic errors); CESC trans rs61931739 0.517 rs860950 chr12:34104376 C/G cg26384229 chr12:38710491 ALG10B 0.52 7.06 0.4 1.45e-11 Morning vs. evening chronotype; CESC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg18876405 chr7:65276391 NA 0.49 5.83 0.34 1.62e-8 Aortic root size; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04815758 chr6:43423089 DLK2 0.41 6.07 0.35 4.32e-9 Intelligence (multi-trait analysis); CESC cis rs4642101 0.686 rs13085726 chr3:12832672 A/C cg24848339 chr3:12840334 CAND2 0.39 6.1 0.35 3.71e-9 QRS complex (12-leadsum); CESC cis rs7208859 0.623 rs1061343 chr17:29114276 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg06221963 chr1:154839813 KCNN3 -0.66 -11.44 -0.58 6.67e-25 Prostate cancer; CESC cis rs1801251 1.000 rs2592102 chr2:233726772 G/T cg08000102 chr2:233561755 GIGYF2 -0.69 -9.79 -0.52 1.6e-19 Coronary artery disease; CESC cis rs7520050 0.751 rs592214 chr1:46024505 G/A cg06784218 chr1:46089804 CCDC17 -0.33 -5.76 -0.33 2.29e-8 Red blood cell count;Reticulocyte count; CESC cis rs2408955 0.522 rs3997 chr12:48481587 T/C cg04545296 chr12:48745243 ZNF641 -0.39 -6.71 -0.38 1.2e-10 Glycated hemoglobin levels; CESC cis rs7520050 0.966 rs10789475 chr1:46304177 C/G cg03146154 chr1:46216737 IPP -0.48 -6.36 -0.36 8.91e-10 Red blood cell count;Reticulocyte count; CESC cis rs2652834 0.851 rs4468558 chr15:63346681 T/C cg05507819 chr15:63340323 TPM1 0.59 5.8 0.34 1.85e-8 HDL cholesterol; CESC cis rs7078219 0.543 rs7096296 chr10:101277816 A/G cg09788492 chr10:101292477 NKX2-3 -0.3 -5.61 -0.33 5.03e-8 Dental caries; CESC cis rs9303401 0.538 rs2240258 chr17:56458183 C/A cg25039879 chr17:56429692 SUPT4H1 0.7 6.8 0.39 6.75e-11 Cognitive test performance; CESC cis rs7312933 0.510 rs10880223 chr12:42413443 G/A cg01256987 chr12:42539512 GXYLT1 -0.45 -6.95 -0.39 2.81e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs11078597 0.731 rs12946666 chr17:1651304 C/G cg18436246 chr17:1640651 WDR81 0.61 7.43 0.42 1.46e-12 Serum albumin level; CESC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg27170947 chr2:26402098 FAM59B -0.68 -8.02 -0.44 3.52e-14 Gut microbiome composition (summer); CESC cis rs2280018 1.000 rs2280017 chr16:15151361 A/G cg07549590 chr16:15018862 NA 0.48 7.91 0.44 7.1e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.82 0.34 1.74e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6963495 0.745 rs73192151 chr7:105211876 A/G cg19920283 chr7:105172520 RINT1 0.7 6.36 0.36 8.94e-10 Bipolar disorder (body mass index interaction); CESC cis rs2204008 0.654 rs1733410 chr12:38132172 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.92 -0.34 9.92e-9 Bladder cancer; CESC cis rs1580019 0.665 rs34147895 chr7:32531796 G/C cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.28 0.36 1.37e-9 Cognitive ability; CESC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs6754311 0.551 rs10928545 chr2:136501840 A/G cg15123519 chr2:136567270 LCT 0.3 5.05 0.3 8.29e-7 Mosquito bite size; CESC cis rs7829975 0.714 rs60315134 chr8:8670599 A/G cg15556689 chr8:8085844 FLJ10661 0.43 5.44 0.32 1.18e-7 Mood instability; CESC cis rs9467711 0.659 rs66941101 chr6:26530376 C/T cg21479132 chr6:26055353 NA 0.72 5.15 0.3 5.19e-7 Autism spectrum disorder or schizophrenia; CESC trans rs459571 1.000 rs467387 chr9:136907005 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.66 -8.4 -0.46 2.81e-15 Platelet distribution width; CESC cis rs3749237 0.595 rs4855864 chr3:49521974 C/T cg03060546 chr3:49711283 APEH 0.78 11.82 0.59 3.47e-26 Resting heart rate; CESC cis rs34891900 0.507 rs2535679 chr22:18202850 A/G cg19898043 chr22:18121309 BCL2L13 0.57 6.78 0.38 7.99e-11 Sum neutrophil eosinophil counts; CESC cis rs6545883 0.931 rs9807965 chr2:61732159 T/C cg15711740 chr2:61764176 XPO1 -0.42 -5.3 -0.31 2.48e-7 Tuberculosis; CESC cis rs6032067 0.777 rs34073275 chr20:43788917 C/T cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg23281280 chr6:28129359 ZNF389 0.62 8.72 0.47 3.21e-16 Depression; CESC cis rs524023 0.914 rs4930556 chr11:64377726 G/C cg07220939 chr11:64358617 SLC22A12 -0.35 -5.32 -0.31 2.24e-7 Urate levels in obese individuals; CESC cis rs4927850 0.752 rs7624460 chr3:195748530 C/T cg00031303 chr3:195681400 NA 0.43 5.34 0.31 1.96e-7 Pancreatic cancer; CESC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg11742103 chr11:62369870 EML3;MTA2 0.62 9.63 0.51 5.18e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg21899992 chr5:179306587 TBC1D9B 0.51 7.42 0.41 1.63e-12 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11048434 0.761 rs1805765 chr12:9094548 A/G cg04155231 chr12:9217510 LOC144571 0.34 5.41 0.32 1.41e-7 Sjögren's syndrome; CESC cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg03213289 chr20:61660250 NA 0.38 5.95 0.34 8.37e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs208520 1.000 rs12191598 chr6:66983962 T/C cg07460842 chr6:66804631 NA 0.88 10.14 0.53 1.22e-20 Exhaled nitric oxide output; CESC cis rs3733585 0.673 rs116046986 chr4:9957794 A/G cg02734326 chr4:10020555 SLC2A9 -0.42 -5.92 -0.34 9.7e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs72781680 0.706 rs72796108 chr2:23904990 C/A cg08917208 chr2:24149416 ATAD2B 1.16 10.42 0.54 1.59e-21 Lymphocyte counts; CESC cis rs9308433 0.505 rs867446 chr1:214502322 G/T cg06198575 chr1:214491504 SMYD2 0.46 5.23 0.31 3.48e-7 IgG glycosylation; CESC cis rs1949733 1.000 rs1916326 chr4:8500023 G/A cg11789530 chr4:8429930 ACOX3 -0.76 -10.74 -0.55 1.45e-22 Response to antineoplastic agents; CESC cis rs2635047 0.713 rs9952628 chr18:44754651 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 5.64 0.33 4.41e-8 Educational attainment; CESC cis rs9905704 0.560 rs2632507 chr17:56530597 C/A cg12560992 chr17:57184187 TRIM37 0.57 5.46 0.32 1.12e-7 Testicular germ cell tumor; CESC cis rs4253772 0.530 rs9615961 chr22:46754993 T/C cg18190219 chr22:46762943 CELSR1 -0.67 -6.19 -0.36 2.32e-9 LDL cholesterol;Cholesterol, total; CESC cis rs6539267 0.847 rs17217845 chr12:106697802 C/T cg02476566 chr12:106696527 TCP11L2 -0.63 -6.63 -0.38 1.83e-10 Tourette syndrome; CESC trans rs116095464 0.558 rs28558836 chr5:285748 C/G cg00938859 chr5:1591904 SDHAP3 0.64 7.04 0.4 1.65e-11 Breast cancer; CESC cis rs9549367 0.774 rs9549364 chr13:113903745 T/C cg00898013 chr13:113819073 PROZ -0.53 -7.21 -0.41 5.74e-12 Platelet distribution width; CESC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs1707322 0.928 rs61785614 chr1:46446047 A/G cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7301826 0.610 rs4759791 chr12:131296495 A/G cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC cis rs6582630 0.519 rs11182021 chr12:38443709 A/T cg13010199 chr12:38710504 ALG10B -0.43 -5.55 -0.32 6.99e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs34779708 0.702 rs4244995 chr10:35547175 A/G cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs9768139 0.733 rs13309363 chr7:158122179 C/A cg06219351 chr7:158114137 PTPRN2 -0.49 -7.54 -0.42 7.44e-13 Calcium levels; CESC cis rs9323205 0.731 rs56024569 chr14:51697655 A/G cg23942311 chr14:51606299 NA -0.46 -5.17 -0.3 4.65e-7 Cancer; CESC cis rs617791 0.678 rs551659 chr11:65749645 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.44 5.81 0.34 1.83e-8 Breast cancer; CESC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.83 9.27 0.49 6.85e-18 Platelet count; CESC cis rs1843834 0.539 rs2047135 chr2:225427302 G/C cg22509189 chr2:225307070 NA -0.4 -5.36 -0.31 1.77e-7 IgE levels in asthmatics (D.p. specific); CESC cis rs6432018 1.000 rs6432018 chr2:9721896 C/A cg23886495 chr2:9695866 ADAM17 0.44 5.14 0.3 5.32e-7 Heart rate variability traits; CESC cis rs2228479 0.717 rs9282682 chr16:89805794 A/G cg04287289 chr16:89883240 FANCA 0.63 5.81 0.34 1.82e-8 Skin colour saturation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07475247 chr7:102938279 PMPCB 0.48 6.21 0.36 2.08e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs1577917 0.958 rs12215232 chr6:86785430 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.82 -0.34 1.66e-8 Response to antipsychotic treatment; CESC cis rs1707322 1.000 rs1768801 chr1:46549137 C/G cg03146154 chr1:46216737 IPP -0.69 -9.04 -0.49 3.51e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17376456 1.000 rs10514382 chr5:93566534 G/A cg21475434 chr5:93447410 FAM172A 0.85 6.52 0.37 3.53e-10 Diabetic retinopathy; CESC trans rs208520 0.690 rs4386800 chr6:66755242 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 11.91 0.59 1.73e-26 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19968619 chr21:42676391 NA -0.54 -6.11 -0.35 3.54e-9 Gut microbiome composition (summer); CESC cis rs79387448 0.655 rs75579337 chr2:102917302 C/A cg09003973 chr2:102972529 NA 1.07 7.99 0.44 4.25e-14 Gut microbiota (bacterial taxa); CESC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg22764044 chr5:178986830 RUFY1 -0.48 -7.21 -0.4 5.91e-12 Lung cancer; CESC cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg14345882 chr6:26364793 BTN3A2 0.41 5.12 0.3 5.89e-7 Intelligence (multi-trait analysis); CESC cis rs11252926 0.673 rs10795161 chr10:497748 G/T cg16386425 chr10:429943 DIP2C -0.45 -5.89 -0.34 1.16e-8 Psychosis in Alzheimer's disease; CESC cis rs748404 0.723 rs565658 chr15:43556307 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.96 0.44 4.96e-14 Lung cancer; CESC cis rs2370759 1.000 rs79442609 chr10:32608749 C/T cg18270830 chr10:32634957 EPC1 0.71 6.83 0.39 5.84e-11 Sexual dysfunction (female); CESC cis rs4253772 0.591 rs6520010 chr22:46721223 G/A cg18190219 chr22:46762943 CELSR1 -0.44 -5.6 -0.33 5.38e-8 LDL cholesterol;Cholesterol, total; CESC trans rs208520 1.000 rs72880045 chr6:66965232 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 9.42 0.5 2.36e-18 Exhaled nitric oxide output; CESC cis rs12477438 0.520 rs2516830 chr2:99773702 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.62 0.61 6.6e-29 Chronic sinus infection; CESC cis rs3733585 0.673 rs4627861 chr4:9954238 T/G cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg27535044 chr8:82633568 ZFAND1 0.43 6.23 0.36 1.84e-9 Bronchopulmonary dysplasia; CESC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.88 15.11 0.68 1.29e-37 Menarche (age at onset); CESC cis rs2425143 0.598 rs2425118 chr20:34324098 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.88e-22 Blood protein levels; CESC cis rs8049634 0.528 rs76669578 chr16:84096577 A/G cg06572904 chr16:84086012 NA -0.51 -5.49 -0.32 9.28e-8 Small cell lung carcinoma; CESC cis rs929596 0.639 rs2070959 chr2:234602191 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -5.73 -0.33 2.66e-8 Total bilirubin levels in HIV-1 infection; CESC cis rs17407555 0.821 rs55851451 chr4:10139189 G/A cg11266682 chr4:10021025 SLC2A9 -0.51 -5.32 -0.31 2.22e-7 Schizophrenia (age at onset); CESC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg11742103 chr11:62369870 EML3;MTA2 0.56 8.08 0.44 2.31e-14 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs8114671 0.552 rs2024635 chr20:33422614 G/A cg06115741 chr20:33292138 TP53INP2 0.45 5.32 0.31 2.21e-7 Height; CESC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.0 -0.4 2.04e-11 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12476490 chr10:64576179 EGR2 -0.61 -7.08 -0.4 1.26e-11 Gut microbiome composition (summer); CESC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.45 -6.4 -0.37 6.88e-10 Bipolar disorder; CESC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg17971929 chr21:40555470 PSMG1 0.59 7.72 0.43 2.41e-13 Menarche (age at onset); CESC cis rs11583043 0.667 rs873760 chr1:101540561 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 5.41 0.32 1.42e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs17253792 0.822 rs80085988 chr14:56096173 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.92 9.83 0.52 1.17e-19 Platelet count; CESC cis rs7666738 0.546 rs11097591 chr4:98910173 G/A cg17366294 chr4:99064904 C4orf37 0.47 5.66 0.33 3.94e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2046867 0.818 rs6808341 chr3:72914847 A/G cg25664220 chr3:72788482 NA -0.39 -5.87 -0.34 1.3e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg05564831 chr3:52568323 NT5DC2 0.48 7.5 0.42 9.67e-13 Electroencephalogram traits; CESC cis rs7089973 0.624 rs10885613 chr10:116589400 G/A cg23260525 chr10:116636907 FAM160B1 0.4 7.19 0.4 6.76e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs721399 0.553 rs10109286 chr8:18243603 A/G cg18736775 chr8:18248649 NAT2 -0.53 -5.86 -0.34 1.35e-8 Blood metabolite levels; CESC cis rs881375 0.900 rs1930786 chr9:123691469 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.14 0.3 5.24e-7 Rheumatoid arthritis; CESC trans rs7819412 0.521 rs9329238 chr8:11033737 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -6.29 -0.36 1.33e-9 Triglycerides; CESC cis rs8064299 0.597 rs2166703 chr17:72781812 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.85 14.24 0.66 1.5e-34 Monocyte count; CESC cis rs11864453 0.647 rs7194397 chr16:72128299 C/T cg16558253 chr16:72132732 DHX38 -0.54 -8.48 -0.46 1.59e-15 Fibrinogen levels; CESC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg18016565 chr1:150552671 MCL1 0.34 5.04 0.3 8.8e-7 Melanoma; CESC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.04 0.3 8.59e-7 Menopause (age at onset); CESC cis rs2337406 0.714 rs7152055 chr14:107227228 C/T cg07958169 chr14:107095056 NA -0.48 -5.12 -0.3 5.89e-7 Alzheimer's disease (late onset); CESC cis rs4727027 0.933 rs4727028 chr7:148874666 A/G cg23583168 chr7:148888333 NA 0.79 12.11 0.6 3.54e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1153858 1.000 rs8042786 chr15:45703539 T/C cg14582100 chr15:45693742 SPATA5L1 0.41 5.79 0.33 2.03e-8 Homoarginine levels; CESC cis rs7777484 0.534 rs2258709 chr7:2832365 C/T cg09658497 chr7:2847517 GNA12 0.43 6.8 0.39 6.83e-11 Height; CESC cis rs472109 0.785 rs415895 chr11:9769562 C/G cg03108697 chr11:9732066 SWAP70 -0.41 -6.14 -0.35 2.96e-9 Coronary artery disease; CESC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg22920501 chr2:26401640 FAM59B -0.79 -9.31 -0.5 5.24e-18 Gut microbiome composition (summer); CESC cis rs10089 1.000 rs13355233 chr5:127425350 A/G cg19767477 chr5:127420684 SLC12A2 0.43 5.9 0.34 1.08e-8 Ileal carcinoids; CESC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg00149659 chr3:10157352 C3orf10 0.71 8.29 0.45 5.55e-15 Alzheimer's disease; CESC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg13393036 chr8:95962371 TP53INP1 -0.47 -10.14 -0.53 1.27e-20 Type 2 diabetes; CESC cis rs807669 0.903 rs1780642 chr22:19170604 T/C cg02655711 chr22:19163373 SLC25A1 0.95 14.43 0.66 3.1e-35 Metabolite levels; CESC cis rs7647973 0.600 rs13064780 chr3:49274826 T/G cg03060546 chr3:49711283 APEH 0.51 6.82 0.39 6.1e-11 Menarche (age at onset); CESC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg05872129 chr22:39784769 NA -0.86 -11.83 -0.59 3.41e-26 Intelligence (multi-trait analysis); CESC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg22764044 chr5:178986830 RUFY1 0.45 6.5 0.37 3.88e-10 Lung cancer; CESC cis rs1620921 0.505 rs9458030 chr6:161209985 G/A cg01280913 chr6:161186852 NA -0.39 -5.83 -0.34 1.6e-8 Lipoprotein (a) - cholesterol levels; CESC cis rs8027181 0.617 rs28827493 chr15:73083121 G/A cg25632853 chr15:73088954 NA -0.39 -5.95 -0.34 8.45e-9 Triglyceride levels; CESC cis rs963731 0.649 rs1947432 chr2:39227063 C/T cg04010122 chr2:39346883 SOS1 0.68 5.21 0.3 3.74e-7 Corticobasal degeneration; CESC cis rs826838 1.000 rs55828987 chr12:39056421 A/C cg13010199 chr12:38710504 ALG10B 0.58 8.03 0.44 3.13e-14 Heart rate; CESC cis rs910316 1.000 rs10138183 chr14:75615227 T/C cg08847533 chr14:75593920 NEK9 1.02 19.83 0.77 2.88e-54 Height; CESC cis rs1065852 0.510 rs5758666 chr22:42632833 G/A cg00645731 chr22:42541494 CYP2D7P1 0.37 6.07 0.35 4.31e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.0 9.67 0.51 3.78e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9486719 1.000 rs2273622 chr6:97058567 A/G cg18709589 chr6:96969512 KIAA0776 -0.53 -5.89 -0.34 1.19e-8 Migraine;Coronary artery disease; CESC cis rs34638657 0.702 rs12599988 chr16:82200063 T/C cg09439754 chr16:82129088 HSD17B2 -0.37 -6.42 -0.37 6.31e-10 Lung adenocarcinoma; CESC cis rs11122272 0.735 rs2474633 chr1:231486989 A/C cg06096015 chr1:231504339 EGLN1 0.42 6.08 0.35 4.12e-9 Hemoglobin concentration; CESC cis rs7772486 0.686 rs702305 chr6:145973840 A/G cg05347473 chr6:146136440 FBXO30 -0.55 -7.18 -0.4 6.9e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7020830 0.898 rs495863 chr9:37346955 T/C cg14294708 chr9:37120828 ZCCHC7 1.09 18.86 0.76 6.59e-51 Schizophrenia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16265552 chr3:113667068 ZDHHC23 0.49 6.58 0.37 2.57e-10 Systemic lupus erythematosus; CESC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg05368731 chr17:41323189 NBR1 0.8 10.98 0.56 2.35e-23 Menopause (age at onset); CESC cis rs938554 0.578 rs7663032 chr4:9993838 C/T cg00071950 chr4:10020882 SLC2A9 0.69 9.03 0.48 3.75e-17 Blood metabolite levels; CESC cis rs2066819 1.000 rs76745316 chr12:56627652 A/C cg26714650 chr12:56694279 CS -1.53 -10.32 -0.54 3.19e-21 Psoriasis vulgaris; CESC cis rs4242434 0.927 rs11781149 chr8:22473158 C/T cg03733263 chr8:22462867 KIAA1967 0.94 13.12 0.63 1.2e-30 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC trans rs11971186 1.000 rs2299521 chr7:126431625 T/A cg10894441 chr11:111169905 C11orf92;C11orf93 0.49 6.05 0.35 5.04e-9 Chemerin levels; CESC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg09699651 chr6:150184138 LRP11 0.43 5.41 0.32 1.42e-7 Lung cancer; CESC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs6062302 0.522 rs13038448 chr20:62218453 C/T cg09650180 chr20:62225654 GMEB2 -0.8 -8.97 -0.48 5.35e-17 Glioblastoma; CESC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg24829409 chr8:58192753 C8orf71 -0.5 -6.18 -0.36 2.37e-9 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg24829409 chr8:58192753 C8orf71 0.69 8.02 0.44 3.34e-14 Developmental language disorder (linguistic errors); CESC cis rs854765 0.583 rs11650649 chr17:17790319 C/A cg16928487 chr17:17741425 SREBF1 0.61 10.63 0.55 3.17e-22 Total body bone mineral density; CESC cis rs854765 0.583 rs66531105 chr17:17809001 C/T cg16928487 chr17:17741425 SREBF1 -0.56 -9.71 -0.51 2.83e-19 Total body bone mineral density; CESC cis rs8028182 0.636 rs7184046 chr15:75866150 G/C cg20655648 chr15:75932815 IMP3 0.48 5.89 0.34 1.19e-8 Sudden cardiac arrest; CESC cis rs9929218 1.000 rs13334326 chr16:68809207 C/T cg02972257 chr16:68554789 NA 0.43 5.08 0.3 7.13e-7 Colorectal cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24219929 chr15:60884748 RORA -0.52 -6.26 -0.36 1.52e-9 Ulcerative colitis; CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg07167872 chr1:205819463 PM20D1 0.8 13.95 0.65 1.5e-33 Menarche (age at onset); CESC cis rs736801 0.780 rs2188962 chr5:131770805 C/T cg07395648 chr5:131743802 NA -0.43 -5.41 -0.32 1.42e-7 Breast cancer;Mosquito bite size; CESC cis rs8060686 0.641 rs12600199 chr16:68069742 C/T cg26727032 chr16:67993705 SLC12A4 -0.54 -6.21 -0.36 2.01e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs6545883 0.929 rs3732170 chr2:61749716 C/T cg15711740 chr2:61764176 XPO1 -0.44 -5.47 -0.32 1.05e-7 Tuberculosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04686114 chr12:57081832 PTGES3 -0.47 -6.99 -0.39 2.22e-11 Fibrinogen levels; CESC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg12311346 chr5:56204834 C5orf35 0.87 10.78 0.55 1.05e-22 Initial pursuit acceleration; CESC trans rs6759922 1.000 rs10865093 chr2:22459372 T/C cg21162304 chr4:80247171 NAA11 0.38 6.09 0.35 3.88e-9 Subjective well-being (multi-trait analysis); CESC cis rs854765 0.647 rs854763 chr17:18010095 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.63 8.77 0.47 2.21e-16 Total body bone mineral density; CESC cis rs7116495 0.609 rs6592447 chr11:71641093 A/T cg10381502 chr11:71823885 C11orf51 -1.09 -7.67 -0.43 3.3e-13 Severe influenza A (H1N1) infection; CESC cis rs9640161 0.658 rs74348353 chr7:150053655 C/A cg10018233 chr7:150070692 REPIN1 0.41 5.85 0.34 1.41e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs2470135 1 rs2470135 chr15:43995789 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.49 6.16 0.35 2.7e-9 Diastolic blood pressure; CESC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg22143856 chr6:28129313 ZNF389 0.49 6.25 0.36 1.64e-9 Depression; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02388999 chr6:131384671 EPB41L2 -0.43 -6.08 -0.35 4.07e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.611 rs34982650 chr4:98819530 T/A cg17366294 chr4:99064904 C4orf37 0.55 7.5 0.42 9.71e-13 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25130390 chr15:65810150 DPP8 0.56 6.41 0.37 6.76e-10 Gut microbiome composition (summer); CESC cis rs4986811 1.000 rs5030157 chr11:32450825 C/T cg27409910 chr11:32454216 WT1 0.44 5.52 0.32 7.9e-8 Rubella-specific interleukin-6 secretion; CESC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg12718519 chr1:2058417 PRKCZ 0.25 5.34 0.31 2.03e-7 Height; CESC cis rs765787 0.530 rs1648285 chr15:45517505 C/G cg24006582 chr15:45444508 DUOX1 -0.56 -6.74 -0.38 9.92e-11 Uric acid levels; CESC cis rs11997175 0.740 rs4467902 chr8:33693415 G/T ch.8.33884649F chr8:33765107 NA 0.44 5.62 0.33 4.75e-8 Body mass index; CESC cis rs9911578 0.967 rs12603238 chr17:57130785 C/T cg12560992 chr17:57184187 TRIM37 -1.02 -17.96 -0.74 9.86e-48 Intelligence (multi-trait analysis); CESC cis rs7605827 0.897 rs9973344 chr2:15632583 G/T cg19274914 chr2:15703543 NA 0.37 6.52 0.37 3.45e-10 Educational attainment (years of education); CESC trans rs9329221 0.537 rs6601415 chr8:9976805 C/A cg15556689 chr8:8085844 FLJ10661 0.51 6.53 0.37 3.33e-10 Neuroticism; CESC cis rs2213920 0.516 rs34302658 chr9:118168158 T/A cg13918206 chr9:118159781 DEC1 -0.67 -5.5 -0.32 9.03e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CESC cis rs28595532 0.702 rs72670250 chr4:119337134 T/C cg21605333 chr4:119757512 SEC24D 0.99 5.78 0.33 2.05e-8 Cannabis dependence symptom count; CESC cis rs1983891 0.955 rs7753653 chr6:41548430 C/T cg20194872 chr6:41519635 FOXP4 -0.55 -7.77 -0.43 1.68e-13 Prostate cancer; CESC cis rs34779708 0.931 rs35886556 chr10:35334985 C/T cg03585969 chr10:35415529 CREM 0.75 9.89 0.52 7.72e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs2072732 0.861 rs12040299 chr1:2951041 C/T cg03976712 chr1:2946727 NA 0.33 5.58 0.32 6.04e-8 Plateletcrit; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13171016 chr1:40219054 PPIE 0.45 6.39 0.37 7.33e-10 Fibrinogen levels; CESC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg16606324 chr3:10149918 C3orf24 0.42 5.16 0.3 4.9e-7 Alzheimer's disease; CESC trans rs8057939 0.593 rs12598511 chr16:49434930 A/G cg15532236 chr6:170188124 NA 0.49 6.1 0.35 3.68e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1153858 1.000 rs67831559 chr15:45649307 G/T cg21132104 chr15:45694354 SPATA5L1 0.84 11.42 0.57 7.96e-25 Homoarginine levels; CESC cis rs12701220 0.542 rs6957866 chr7:1111674 G/A cg26769984 chr7:1090371 C7orf50 0.56 5.68 0.33 3.52e-8 Bronchopulmonary dysplasia; CESC cis rs7107174 1.000 rs10899457 chr11:78001163 T/A cg02023728 chr11:77925099 USP35 0.5 6.63 0.38 1.85e-10 Testicular germ cell tumor; CESC cis rs57083693 0.518 rs10778113 chr12:101741961 G/A cg22051763 chr12:101673672 UTP20 -0.42 -5.3 -0.31 2.47e-7 Alcohol dependence (age at onset); CESC cis rs6570726 0.791 rs379040 chr6:145889035 T/C cg05347473 chr6:146136440 FBXO30 0.54 7.08 0.4 1.28e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg08499158 chr17:42289980 UBTF -0.47 -5.74 -0.33 2.53e-8 Total body bone mineral density; CESC trans rs5769765 0.908 rs9616376 chr22:50310829 A/G cg09872104 chr7:134855509 C7orf49 -0.55 -6.27 -0.36 1.47e-9 Schizophrenia; CESC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg24060327 chr5:131705240 SLC22A5 0.51 6.57 0.37 2.69e-10 Acylcarnitine levels; CESC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg19774624 chr17:42201019 HDAC5 -0.9 -14.84 -0.67 1.09e-36 Total body bone mineral density; CESC cis rs78456975 1.000 rs10208449 chr2:1563257 G/A cg01028140 chr2:1542097 TPO -0.63 -5.87 -0.34 1.29e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4722585 0.533 rs3753097 chr7:26198207 A/G cg07876897 chr7:26191696 NFE2L3 0.44 5.62 0.33 4.89e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); CESC cis rs3809566 0.963 rs3809565 chr15:63333619 A/G cg05507819 chr15:63340323 TPM1 0.5 6.0 0.35 6.42e-9 Platelet count; CESC cis rs193541 0.632 rs430069 chr5:122263351 G/A cg19412675 chr5:122181750 SNX24 0.42 5.1 0.3 6.39e-7 Glucose homeostasis traits; CESC cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg06627628 chr2:24431161 ITSN2 -0.67 -6.33 -0.36 1.06e-9 Lymphocyte counts; CESC cis rs2688608 0.592 rs10824032 chr10:75528130 G/A cg23231163 chr10:75533350 FUT11 -0.35 -5.31 -0.31 2.33e-7 Inflammatory bowel disease; CESC cis rs6840258 1.000 rs56406125 chr4:87940205 G/T cg08197287 chr4:87952173 AFF1 -0.41 -5.24 -0.31 3.23e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26612947 chr15:75495112 C15orf39 -0.56 -6.22 -0.36 1.9e-9 Gut microbiome composition (summer); CESC cis rs10779751 1.000 rs4845986 chr1:11288633 G/C cg08854313 chr1:11322531 MTOR 0.83 11.83 0.59 3.29e-26 Body mass index; CESC trans rs35110281 0.805 rs162402 chr21:44963418 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.44 0.37 5.53e-10 Mean corpuscular volume; CESC cis rs11658309 1 rs11658309 chr17:17762247 T/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.49 -6.58 -0.37 2.43e-10 Strep throat; CESC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg04944784 chr2:26401820 FAM59B 0.89 9.24 0.49 8.39e-18 Gut microbiome composition (summer); CESC cis rs929354 1.000 rs1182391 chr7:157038368 T/C cg05182265 chr7:156933206 UBE3C 0.4 5.5 0.32 9.06e-8 Body mass index; CESC cis rs752010 0.841 rs17363834 chr1:42076607 C/T cg06885757 chr1:42089581 HIVEP3 0.47 7.59 0.42 5.33e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs10744422 1.000 rs7139055 chr12:123364198 A/G cg25930673 chr12:123319894 HIP1R 0.79 5.92 0.34 9.84e-9 Schizophrenia; CESC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg24829409 chr8:58192753 C8orf71 -0.75 -10.01 -0.52 3.22e-20 Developmental language disorder (linguistic errors); CESC cis rs2404602 0.692 rs35138393 chr15:76977617 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.72 -0.33 2.94e-8 Blood metabolite levels; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg22792938 chr2:228337242 AGFG1 0.47 6.74 0.38 9.98e-11 Bronchopulmonary dysplasia; CESC cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg03467027 chr4:99064603 C4orf37 0.42 5.29 0.31 2.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.774 rs11098505 chr4:120284627 C/T cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02470565 chr22:29702866 GAS2L1 0.58 6.51 0.37 3.77e-10 Gut microbiome composition (summer); CESC cis rs10876993 0.826 rs1678534 chr12:58057435 A/C cg18357645 chr12:58087776 OS9 0.62 9.82 0.52 1.26e-19 Celiac disease or Rheumatoid arthritis; CESC cis rs734999 0.545 rs41300092 chr1:2537838 C/T cg18854424 chr1:2615690 NA 0.3 5.83 0.34 1.65e-8 Ulcerative colitis; CESC cis rs2191566 0.747 rs4803667 chr19:44533604 T/C cg20607764 chr19:44506953 ZNF230 -0.59 -7.45 -0.42 1.28e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg13902645 chr11:5959945 NA -0.67 -9.05 -0.49 3.08e-17 DNA methylation (variation); CESC trans rs875971 1.000 rs778706 chr7:65860424 A/G cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.77e-9 Aortic root size; CESC cis rs7917772 0.619 rs2251772 chr10:104470918 T/C cg22532475 chr10:104410764 TRIM8 -0.37 -5.31 -0.31 2.32e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs8114671 0.562 rs6060064 chr20:33406339 C/G cg08999081 chr20:33150536 PIGU -0.37 -5.32 -0.31 2.22e-7 Height; CESC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg04369109 chr6:150039330 LATS1 -0.4 -5.5 -0.32 9.07e-8 Lung cancer; CESC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg22029157 chr1:209979665 IRF6 0.76 8.93 0.48 7.36e-17 Cleft lip with or without cleft palate; CESC cis rs3733585 0.673 rs9994266 chr4:9954450 C/T cg02734326 chr4:10020555 SLC2A9 -0.39 -5.61 -0.33 5.13e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg00166722 chr3:10149974 C3orf24 0.52 6.38 0.36 7.91e-10 Alzheimer's disease; CESC cis rs2549003 0.966 rs839 chr5:131819126 C/T cg02551604 chr5:131831745 NA -0.37 -5.22 -0.31 3.53e-7 Asthma (sex interaction); CESC cis rs5753618 0.561 rs13054220 chr22:31704492 A/G cg00478049 chr22:31556069 RNF185 -0.45 -5.04 -0.3 8.52e-7 Colorectal cancer; CESC cis rs7520050 0.966 rs6668284 chr1:46354510 G/A cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.42e-7 Red blood cell count;Reticulocyte count; CESC cis rs4076764 1.000 rs4076764 chr1:163441286 A/G cg24596788 chr1:163392923 NA -0.46 -6.73 -0.38 1.05e-10 Motion sickness; CESC trans rs386965 0.545 rs2348180 chr16:79650056 T/A cg27092986 chr12:7858592 NA -0.43 -6.23 -0.36 1.78e-9 Multiple sclerosis; CESC cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg19193384 chr17:30244184 NA -0.71 -6.6 -0.38 2.17e-10 Hip circumference adjusted for BMI; CESC cis rs1707322 1.000 rs946524 chr1:46487560 A/G cg03146154 chr1:46216737 IPP -0.72 -9.88 -0.52 8.55e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg18904891 chr8:8559673 CLDN23 -0.67 -8.11 -0.45 1.84e-14 Obesity-related traits; CESC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg14709524 chr16:89940631 TCF25 0.89 6.55 0.37 2.99e-10 Skin colour saturation; CESC cis rs2463822 0.925 rs12292586 chr11:62156312 C/T cg06239285 chr11:62104954 ASRGL1 -0.98 -8.69 -0.47 3.91e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs344364 0.511 rs911392 chr16:1947259 A/G cg26617929 chr16:1858877 NA -0.49 -5.24 -0.31 3.24e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg13298116 chr11:62369859 EML3;MTA2 0.53 7.43 0.42 1.47e-12 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg13147721 chr7:65941812 NA 0.38 5.36 0.31 1.77e-7 Aortic root size; CESC cis rs733592 0.507 rs10875739 chr12:48480919 C/T cg24011408 chr12:48396354 COL2A1 0.49 7.94 0.44 5.87e-14 Plateletcrit; CESC cis rs9300255 0.512 rs2851436 chr12:123667354 G/T cg05973401 chr12:123451056 ABCB9 0.49 5.49 0.32 9.51e-8 Neutrophil percentage of white cells; CESC cis rs1707322 1.000 rs11211239 chr1:46451947 A/G cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6964587 1.000 rs415 chr7:91580490 A/G cg17063962 chr7:91808500 NA -0.57 -7.68 -0.43 3.06e-13 Breast cancer; CESC cis rs3204270 0.759 rs8066217 chr17:79672615 C/G cg18367735 chr17:79674897 NA 0.66 5.46 0.32 1.12e-7 Dental caries; CESC cis rs6484504 0.576 rs9971609 chr11:31434104 C/T cg14844989 chr11:31128820 NA 0.42 5.84 0.34 1.49e-8 Red blood cell count; CESC cis rs7412746 0.658 rs10888397 chr1:150886752 A/G cg22823121 chr1:150693482 HORMAD1 -0.37 -5.18 -0.3 4.47e-7 Melanoma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11869233 chr2:48009809 MSH6 0.48 6.8 0.39 7.11e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17818399 1.000 rs17818399 chr2:46826026 A/C cg02822958 chr2:46747628 ATP6V1E2 0.48 5.97 0.34 7.53e-9 Height; CESC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.67 -0.33 3.77e-8 Total body bone mineral density; CESC cis rs67311347 0.713 rs4974018 chr3:40307419 G/A cg09455208 chr3:40491958 NA 0.43 7.28 0.41 3.69e-12 Renal cell carcinoma; CESC cis rs4523957 0.651 rs4790316 chr17:2074977 T/C cg16513277 chr17:2031491 SMG6 -0.69 -9.45 -0.5 1.87e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.15 -0.4 8.38e-12 Total body bone mineral density; CESC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg13206674 chr6:150067644 NUP43 0.46 6.63 0.38 1.84e-10 Lung cancer; CESC trans rs116095464 0.558 rs10075018 chr5:239175 G/A cg00938859 chr5:1591904 SDHAP3 0.65 7.19 0.4 6.47e-12 Breast cancer; CESC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg21782813 chr7:2030301 MAD1L1 0.43 6.09 0.35 3.99e-9 Bipolar disorder and schizophrenia; CESC cis rs523522 0.962 rs10849758 chr12:120971149 C/T cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs9611565 0.649 rs2413659 chr22:42164862 A/G cg03806693 chr22:41940476 POLR3H 0.8 9.72 0.51 2.66e-19 Vitiligo; CESC cis rs698833 0.886 rs698766 chr2:44574277 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.81 0.34 1.77e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18548362 chr4:1857197 LETM1 0.66 8.08 0.44 2.28e-14 Gut microbiome composition (summer); CESC cis rs941408 0.515 rs2110118 chr19:2775144 T/C cg02580895 chr19:2754563 NA -0.46 -6.3 -0.36 1.21e-9 Total cholesterol levels; CESC cis rs2933343 1.000 rs6785869 chr3:128643144 G/A cg25356066 chr3:128598488 ACAD9 0.61 7.52 0.42 8.33e-13 IgG glycosylation; CESC cis rs6500395 0.962 rs7499213 chr16:48680597 T/C cg04672837 chr16:48644449 N4BP1 0.46 5.46 0.32 1.08e-7 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11250098 0.600 rs4240671 chr8:10767748 A/G cg15556689 chr8:8085844 FLJ10661 0.52 6.55 0.37 3.04e-10 Morning vs. evening chronotype; CESC cis rs9287719 0.967 rs9679581 chr2:10751736 G/A cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06666157 chr19:4791552 FEM1A -0.53 -7.76 -0.43 1.85e-13 Gambling; CESC cis rs7618501 0.699 rs9821675 chr3:49902544 A/G cg24308560 chr3:49941425 MST1R -0.7 -10.4 -0.54 1.82e-21 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg05368731 chr17:41323189 NBR1 0.77 10.49 0.54 9.27e-22 Menopause (age at onset); CESC cis rs2228479 0.541 rs9806913 chr16:89953773 A/G cg00800038 chr16:89945340 TCF25 -0.64 -7.05 -0.4 1.57e-11 Skin colour saturation; CESC cis rs4728302 0.869 rs10224683 chr7:133590937 A/G cg10665199 chr7:133106180 EXOC4 -0.39 -5.38 -0.31 1.64e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.07 0.4 1.36e-11 Bipolar disorder; CESC cis rs10276381 0.786 rs73089302 chr7:28187134 G/A cg23620719 chr7:28220237 JAZF1 0.74 7.96 0.44 5.01e-14 Crohn's disease; CESC cis rs34779708 0.931 rs66887762 chr10:35330577 C/T cg03585969 chr10:35415529 CREM 0.78 10.23 0.53 6.43e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs1165640 0.522 rs2687735 chr3:193558082 A/G cg21197336 chr3:193587490 NA 0.47 5.38 0.31 1.64e-7 Smoking cessation in chronic obstructive pulmonary disease; CESC cis rs9388451 0.903 rs7758115 chr6:126061502 C/T cg05901451 chr6:126070800 HEY2 -0.64 -9.58 -0.51 7.15e-19 Brugada syndrome; CESC cis rs3008870 0.959 rs2985826 chr1:67412918 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs2295499 0.744 rs2282768 chr4:2716147 A/C cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.22 -0.31 3.62e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs9911578 0.933 rs2531725 chr17:56517962 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.23 0.31 3.52e-7 Intelligence (multi-trait analysis); CESC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg00166722 chr3:10149974 C3orf24 -0.52 -6.89 -0.39 4.13e-11 Alzheimer's disease; CESC cis rs9660992 0.674 rs12122105 chr1:205256818 C/T cg21643547 chr1:205240462 TMCC2 -0.44 -5.92 -0.34 1.01e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs7914558 1.000 rs7914558 chr10:104775908 G/A cg15744005 chr10:104629667 AS3MT -0.33 -5.38 -0.31 1.63e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg11764359 chr7:65958608 NA -0.78 -11.42 -0.57 8.05e-25 Aortic root size; CESC cis rs7246657 0.943 rs10426666 chr19:37828514 C/G cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs5758511 0.633 rs5751258 chr22:42663871 C/G cg00645731 chr22:42541494 CYP2D7P1 0.58 8.76 0.47 2.43e-16 Birth weight; CESC cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg11764359 chr7:65958608 NA 0.82 9.37 0.5 3.25e-18 Aortic root size; CESC cis rs6547741 0.844 rs7382 chr2:27873415 G/A cg27432699 chr2:27873401 GPN1 -0.6 -8.78 -0.47 2.1e-16 Oral cavity cancer; CESC cis rs36051895 0.632 rs10121316 chr9:5147539 C/T cg02405213 chr9:5042618 JAK2 0.47 6.11 0.35 3.53e-9 Pediatric autoimmune diseases; CESC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg08470875 chr2:26401718 FAM59B 0.75 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC cis rs4975709 0.569 rs2353583 chr5:1858834 G/C cg12288994 chr5:1860383 NA 0.42 6.85 0.39 5.21e-11 Cardiovascular disease risk factors; CESC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg07343612 chr16:622815 PIGQ -0.57 -8.34 -0.46 4.2e-15 Height; CESC cis rs11750568 0.967 rs4701034 chr5:178513921 T/C cg10208897 chr5:178548229 ADAMTS2 0.38 5.37 0.31 1.72e-7 Height; CESC cis rs1670533 0.932 rs2045067 chr4:1052355 C/T cg27284194 chr4:1044797 NA 0.45 5.78 0.33 2.07e-8 Recombination rate (females); CESC cis rs9948 1.000 rs10203346 chr2:97517237 A/G cg01990225 chr2:97406019 LMAN2L -0.68 -5.19 -0.3 4.13e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs847577 0.569 rs7804318 chr7:97796635 A/G cg21770322 chr7:97807741 LMTK2 -0.81 -13.47 -0.64 7.67e-32 Breast cancer; CESC cis rs7959452 0.640 rs4274230 chr12:69700772 T/G cg20891283 chr12:69753455 YEATS4 0.77 11.22 0.57 3.71e-24 Blood protein levels; CESC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.68 -9.16 -0.49 1.45e-17 Mean platelet volume; CESC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg04772025 chr11:68637568 NA 0.53 5.97 0.34 7.49e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg01516881 chr6:292596 DUSP22 -0.83 -11.34 -0.57 1.42e-24 Menopause (age at onset); CESC cis rs6912958 0.874 rs2103764 chr6:88157392 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.31 -0.31 2.31e-7 Monocyte percentage of white cells; CESC cis rs9486719 0.947 rs12208556 chr6:96903486 C/T cg06623918 chr6:96969491 KIAA0776 -0.85 -9.54 -0.51 9.97e-19 Migraine;Coronary artery disease; CESC cis rs3820928 1.000 rs3731593 chr2:227773924 A/G cg11843606 chr2:227700838 RHBDD1 -0.45 -5.97 -0.34 7.51e-9 Pulmonary function; CESC cis rs11098499 0.645 rs78422072 chr4:120281042 C/T cg09307838 chr4:120376055 NA 0.85 11.06 0.56 1.25e-23 Corneal astigmatism; CESC cis rs61931739 0.500 rs11053280 chr12:34559297 G/T cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs1728785 1.000 rs1170436 chr16:68607486 T/A cg02972257 chr16:68554789 NA -0.6 -6.82 -0.39 6.06e-11 Ulcerative colitis; CESC cis rs4342066 0.593 rs34692982 chr3:28276558 A/T cg15038811 chr3:28283857 CMC1 0.39 5.04 0.3 8.55e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 0.534 rs2757053 chr6:167380338 A/C cg23791538 chr6:167370224 RNASET2 0.7 10.02 0.52 2.95e-20 Crohn's disease; CESC cis rs4523957 0.553 rs2172593 chr17:2025544 G/C cg16513277 chr17:2031491 SMG6 -0.77 -11.34 -0.57 1.43e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01353464 chr3:38180116 ACAA1;MYD88 0.44 6.01 0.35 6e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg12311346 chr5:56204834 C5orf35 -0.45 -5.69 -0.33 3.39e-8 Coronary artery disease; CESC cis rs17764205 0.929 rs10415057 chr19:3255643 C/T cg04171554 chr19:2761892 SGTA -0.55 -5.15 -0.3 4.97e-7 Bipolar disorder and schizophrenia; CESC cis rs1728785 0.818 rs11648503 chr16:68598938 G/A cg02972257 chr16:68554789 NA -0.68 -7.63 -0.42 4.2e-13 Ulcerative colitis; CESC cis rs56235845 0.694 rs11748912 chr5:176765395 G/A cg17509989 chr5:176798049 RGS14 0.49 6.21 0.36 2.02e-9 Hemoglobin concentration;Hematocrit; CESC cis rs10088262 0.629 rs1367829 chr8:124797135 A/G cg15047889 chr8:124780837 FAM91A1 -0.52 -6.58 -0.37 2.57e-10 Pancreatic cancer; CESC cis rs11098499 0.954 rs6822679 chr4:120402702 A/C cg24375607 chr4:120327624 NA 0.44 5.44 0.32 1.19e-7 Corneal astigmatism; CESC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg16325326 chr1:53192061 ZYG11B -0.89 -15.32 -0.69 2.26e-38 Monocyte count; CESC cis rs2243480 0.803 rs423187 chr7:65509499 G/C cg18252515 chr7:66147081 NA -1.33 -13.11 -0.63 1.29e-30 Diabetic kidney disease; CESC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.61 7.06 0.4 1.43e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs3105593 0.933 rs3131588 chr15:50842052 G/T cg08437265 chr15:50716283 USP8 0.42 5.52 0.32 8.18e-8 QT interval; CESC cis rs854765 0.547 rs7209003 chr17:17907393 T/A cg09796270 chr17:17721594 SREBF1 0.39 5.47 0.32 1.06e-7 Total body bone mineral density; CESC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.46 -0.37 4.94e-10 Electroencephalogram traits; CESC cis rs6087990 0.806 rs6088008 chr20:31382860 A/G cg13636640 chr20:31349939 DNMT3B 0.79 12.15 0.6 2.7e-27 Ulcerative colitis; CESC cis rs12950390 1.000 rs12950390 chr17:45830948 A/G cg00777063 chr17:45855553 NA -0.38 -5.07 -0.3 7.5e-7 IgG glycosylation; CESC cis rs644799 1.000 rs11021319 chr11:95523123 C/G cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.61 0.38 2.16e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg23172400 chr8:95962367 TP53INP1 -0.44 -9.22 -0.49 9.93e-18 Type 2 diabetes; CESC cis rs7179456 0.545 rs585192 chr15:59052210 T/C cg05156742 chr15:59063176 FAM63B 0.6 7.59 0.42 5.54e-13 Asperger disorder; CESC cis rs5758511 0.634 rs1001587 chr22:42670111 C/T cg00645731 chr22:42541494 CYP2D7P1 0.58 8.66 0.47 4.81e-16 Birth weight; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg05207227 chr22:29703180 GAS2L1 0.4 6.15 0.35 2.86e-9 Systemic lupus erythematosus; CESC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg19163074 chr7:65112434 INTS4L2 0.52 5.35 0.31 1.87e-7 Aortic root size; CESC cis rs863345 0.504 rs857714 chr1:158566972 C/T cg12129480 chr1:158549410 OR10X1 0.27 5.04 0.3 8.45e-7 Pneumococcal bacteremia; CESC cis rs7312774 0.881 rs12320167 chr12:107310167 G/A cg16260113 chr12:107380972 MTERFD3 0.64 6.08 0.35 4.15e-9 Severe influenza A (H1N1) infection; CESC cis rs2718058 0.519 rs2598071 chr7:37875347 G/A cg15028436 chr7:37888078 TXNDC3 0.51 7.22 0.41 5.62e-12 Alzheimer's disease (late onset); CESC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg03676636 chr4:99064102 C4orf37 0.37 5.41 0.32 1.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10129255 0.500 rs7157975 chr14:107212287 G/A cg23076370 chr14:107095027 NA -0.64 -9.43 -0.5 2.13e-18 Kawasaki disease; CESC cis rs3820068 0.581 rs74054797 chr1:15926217 G/A cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs9929218 0.953 rs17772411 chr16:68810923 T/C cg02972257 chr16:68554789 NA 0.43 5.14 0.3 5.28e-7 Colorectal cancer; CESC cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.15e-16 Colonoscopy-negative controls vs population controls; CESC cis rs722599 0.683 rs8014695 chr14:75301617 C/G cg11812906 chr14:75593930 NEK9 0.45 5.53 0.32 7.6e-8 IgG glycosylation; CESC cis rs2204008 0.774 rs9669565 chr12:38294428 C/A cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Bladder cancer; CESC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9300255 0.602 rs2682431 chr12:123703226 T/A cg05973401 chr12:123451056 ABCB9 0.5 5.68 0.33 3.48e-8 Neutrophil percentage of white cells; CESC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg11764359 chr7:65958608 NA 0.81 11.99 0.59 9.35e-27 Aortic root size; CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg16103275 chr6:290800 DUSP22 0.43 6.0 0.35 6.6e-9 Menopause (age at onset); CESC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg17971929 chr21:40555470 PSMG1 -0.87 -12.61 -0.61 6.96e-29 Cognitive function; CESC trans rs629535 0.814 rs651985 chr8:70054966 G/A cg21567404 chr3:27674614 NA 0.92 10.87 0.56 5.21e-23 Dupuytren's disease; CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg27094323 chr7:1216898 NA -0.42 -5.81 -0.34 1.83e-8 Longevity;Endometriosis; CESC cis rs1215050 0.740 rs6855827 chr4:99065706 G/A cg17366294 chr4:99064904 C4orf37 0.43 5.6 0.33 5.33e-8 Waist-to-hip ratio adjusted for body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09829838 chr6:42952307 PPP2R5D -0.44 -6.17 -0.35 2.5e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20647962 chr15:41136443 SPINT1 0.66 7.64 0.42 3.9e-13 Gut microbiome composition (summer); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg08984023 chr10:64133896 ZNF365 0.44 6.17 0.35 2.54e-9 Psoriatic arthritis; CESC cis rs5769765 0.773 rs9616378 chr22:50311973 A/G cg02269571 chr22:50332266 NA -0.55 -6.79 -0.38 7.53e-11 Schizophrenia; CESC cis rs6942756 0.806 rs1880854 chr7:128949748 G/T cg02491457 chr7:128862824 NA 0.6 8.66 0.47 4.6e-16 White matter hyperintensity burden; CESC cis rs35160687 0.623 rs718292 chr2:86473740 A/G cg01119172 chr2:86362222 SNORD94;PTCD3 0.38 5.18 0.3 4.35e-7 Night sleep phenotypes; CESC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.4 5.25 0.31 3.12e-7 Lymphocyte counts; CESC cis rs733592 0.524 rs10875727 chr12:48426143 T/C cg24011408 chr12:48396354 COL2A1 -0.51 -8.59 -0.47 7.74e-16 Plateletcrit; CESC cis rs2204008 0.715 rs3899385 chr12:38169880 C/G cg13010199 chr12:38710504 ALG10B 0.52 6.6 0.38 2.18e-10 Bladder cancer; CESC cis rs7312933 0.528 rs10880238 chr12:42489613 A/G cg01256987 chr12:42539512 GXYLT1 -0.45 -6.97 -0.39 2.51e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.67 -0.33 3.76e-8 Aortic root size; CESC cis rs34779708 0.643 rs4275563 chr10:35545286 G/A cg03585969 chr10:35415529 CREM 0.55 6.41 0.37 6.66e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18021690 chr1:150039108 VPS45 0.58 6.3 0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.38 0.46 3.24e-15 Bipolar disorder; CESC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.3 -5.12 -0.3 5.82e-7 Bipolar disorder; CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg16145915 chr7:1198662 ZFAND2A -0.47 -5.48 -0.32 9.95e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg17178900 chr1:205818956 PM20D1 0.89 15.71 0.69 9.72e-40 Menarche (age at onset); CESC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg04267008 chr7:1944627 MAD1L1 -0.42 -5.12 -0.3 5.77e-7 Schizophrenia; CESC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg00149659 chr3:10157352 C3orf10 0.7 8.24 0.45 7.79e-15 Alzheimer's disease; CESC cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg05283184 chr6:79620031 NA -0.43 -6.56 -0.37 2.85e-10 Intelligence (multi-trait analysis); CESC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs4689592 0.622 rs2276968 chr4:7070118 T/G cg26116260 chr4:7069785 GRPEL1 0.94 11.44 0.58 6.64e-25 Monocyte percentage of white cells; CESC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg27022615 chr11:70049105 FADD -0.53 -6.8 -0.39 6.81e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg20646317 chr12:50794494 LARP4 0.51 6.55 0.37 3.02e-10 Attention deficit hyperactivity disorder; CESC cis rs7551222 0.749 rs4951409 chr1:204560990 A/T cg20240347 chr1:204465584 NA -0.26 -5.41 -0.32 1.43e-7 Schizophrenia; CESC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg18876405 chr7:65276391 NA 0.49 6.33 0.36 1.02e-9 Calcium levels; CESC cis rs2034088 0.897 rs11652657 chr17:439124 A/G cg13332499 chr17:408570 NA 0.48 8.35 0.46 3.79e-15 Hip circumference adjusted for BMI; CESC cis rs1018836 0.632 rs6988302 chr8:91477660 C/T cg16814680 chr8:91681699 NA -0.62 -8.7 -0.47 3.59e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1008375 1.000 rs7661631 chr4:17679751 T/C cg02297831 chr4:17616191 MED28 -0.48 -5.81 -0.34 1.78e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs116095464 0.558 rs12173244 chr5:269524 G/A cg10591111 chr5:226296 SDHA -0.52 -6.36 -0.36 8.59e-10 Breast cancer; CESC cis rs61931739 0.534 rs10844767 chr12:34152368 C/G cg19457237 chr12:34500585 NA -0.39 -5.35 -0.31 1.93e-7 Morning vs. evening chronotype; CESC cis rs7621025 0.630 rs1681816 chr3:136474762 C/G cg15507776 chr3:136538369 TMEM22 -0.53 -6.23 -0.36 1.81e-9 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs4073221 0.520 rs13072195 chr3:18199498 C/T cg07694806 chr3:18168406 NA -0.66 -5.61 -0.33 5.2e-8 Parkinson's disease; CESC cis rs6500395 0.962 rs3743780 chr16:48647480 A/G cg04672837 chr16:48644449 N4BP1 0.51 6.21 0.36 2.08e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.73 0.38 1.02e-10 Platelet count; CESC cis rs12136530 0.774 rs11590840 chr1:19779673 A/G cg01832549 chr1:19774989 CAPZB -0.45 -6.61 -0.38 2.1e-10 Lead levels in blood; CESC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg17971929 chr21:40555470 PSMG1 0.93 13.11 0.63 1.28e-30 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18845578 chr2:240003174 HDAC4 -0.68 -7.55 -0.42 6.86e-13 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.59 -0.38 2.4e-10 Bipolar disorder; CESC cis rs9467711 0.606 rs9379864 chr6:26372584 G/A cg12826209 chr6:26865740 GUSBL1 0.62 5.24 0.31 3.25e-7 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09863028 chr2:242076577 PASK -0.62 -6.88 -0.39 4.26e-11 Gut microbiome composition (summer); CESC cis rs4474465 0.646 rs4945301 chr11:78283362 A/G cg27205649 chr11:78285834 NARS2 0.48 6.31 0.36 1.14e-9 Alzheimer's disease (survival time); CESC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg27588902 chr6:42928151 GNMT -0.27 -5.15 -0.3 5.2e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4699052 0.787 rs2169508 chr4:104066890 T/A cg16532752 chr4:104119610 CENPE -0.39 -5.21 -0.3 3.79e-7 Testicular germ cell tumor; CESC cis rs2200578 1.000 rs72954221 chr2:99899445 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.5 5.6 0.33 5.23e-8 IgG glycosylation; CESC cis rs2243480 1.000 rs160633 chr7:65528228 T/C cg18252515 chr7:66147081 NA -1.23 -12.45 -0.61 2.44e-28 Diabetic kidney disease; CESC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg03351412 chr1:154909251 PMVK 0.52 6.35 0.36 9.27e-10 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21528620 chr1:110753221 KCNC4 0.67 8.45 0.46 1.94e-15 Gut microbiome composition (summer); CESC trans rs7618501 1.000 rs9872864 chr3:49792023 A/G cg21659725 chr3:3221576 CRBN -0.83 -13.35 -0.63 1.98e-31 Intelligence (multi-trait analysis); CESC cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg21918786 chr6:109611834 NA -0.36 -5.22 -0.31 3.63e-7 Reticulocyte fraction of red cells; CESC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg27266027 chr21:40555129 PSMG1 0.43 5.24 0.31 3.28e-7 Cognitive function; CESC cis rs6665290 0.545 rs6426584 chr1:227374949 A/T cg10327440 chr1:227177885 CDC42BPA -0.9 -13.38 -0.64 1.5e-31 Myeloid white cell count; CESC cis rs3011225 0.710 rs3011222 chr1:44317545 C/T cg13606994 chr1:44402422 ARTN -0.35 -5.14 -0.3 5.31e-7 Amyotrophic lateral sclerosis (age of onset); CESC cis rs10779751 0.727 rs4845852 chr1:11233559 C/T cg08854313 chr1:11322531 MTOR 0.86 12.62 0.61 6.52e-29 Body mass index; CESC cis rs8062405 0.965 rs8049439 chr16:28837515 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -6.16 -0.35 2.74e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9309473 0.950 rs7566364 chr2:73842889 T/C cg20560298 chr2:73613845 ALMS1 -0.43 -5.74 -0.33 2.61e-8 Metabolite levels; CESC cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg11752832 chr7:134001865 SLC35B4 0.55 7.23 0.41 5.27e-12 Mean platelet volume; CESC cis rs826838 0.967 rs1684414 chr12:39129553 A/G cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs1801251 0.778 rs2592116 chr2:233735709 G/A cg25237894 chr2:233734115 C2orf82 -0.5 -8.76 -0.47 2.34e-16 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18366782 chr14:77423080 NA -0.48 -6.8 -0.39 7.05e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2066819 1.000 rs2643623 chr12:56689725 G/C cg26714650 chr12:56694279 CS 1.29 16.3 0.71 7.7e-42 Psoriasis vulgaris; CESC trans rs7178375 1.000 rs4779797 chr15:31208425 C/T cg04373760 chr16:53404718 NA -0.52 -6.85 -0.39 5.05e-11 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23946709 chr14:23527317 CDH24 0.57 6.25 0.36 1.68e-9 Gut microbiome composition (summer); CESC cis rs2180341 1.000 rs2057223 chr6:127637374 T/C cg27446573 chr6:127587934 RNF146 1.09 16.38 0.71 3.79e-42 Breast cancer; CESC cis rs6866344 0.697 rs17184302 chr5:178127676 C/T cg03877680 chr5:178157825 ZNF354A 0.75 8.5 0.46 1.36e-15 Neutrophil percentage of white cells; CESC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg18350739 chr11:68623251 NA -0.46 -7.02 -0.4 1.88e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs12478296 0.792 rs6738361 chr2:243014257 C/T cg06360820 chr2:242988706 NA -0.85 -9.36 -0.5 3.54e-18 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22655561 chr5:176883211 PRR7 -0.72 -8.25 -0.45 7.42e-15 Gut microbiome composition (summer); CESC cis rs9291683 0.935 rs1860911 chr4:10275057 C/T cg00071950 chr4:10020882 SLC2A9 0.55 8.32 0.46 4.7e-15 Bone mineral density; CESC cis rs611744 0.870 rs633794 chr8:109174702 A/G cg21045802 chr8:109455806 TTC35 0.47 5.67 0.33 3.81e-8 Dupuytren's disease; CESC cis rs4803468 1.000 rs284652 chr19:41928652 C/T cg09537434 chr19:41945824 ATP5SL -1.11 -20.58 -0.78 6.86e-57 Height; CESC cis rs9348721 0.673 rs9358934 chr6:26363755 G/C cg12826209 chr6:26865740 GUSBL1 0.62 5.31 0.31 2.27e-7 Intelligence (multi-trait analysis); CESC cis rs7089973 0.604 rs11819372 chr10:116594934 A/G cg25233709 chr10:116636983 FAM160B1 0.37 6.21 0.36 2.05e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs67311347 0.577 rs2371129 chr3:40248393 C/T cg24209194 chr3:40518798 ZNF619 -0.41 -5.08 -0.3 7.26e-7 Renal cell carcinoma; CESC cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg05347473 chr6:146136440 FBXO30 0.73 9.41 0.5 2.43e-18 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18501264 chr19:33555827 RHPN2 -0.53 -7.28 -0.41 3.7e-12 Fibrinogen levels; CESC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg22968622 chr17:43663579 NA 0.78 10.71 0.55 1.83e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4853012 0.838 rs2177707 chr2:74356850 A/G cg01017244 chr2:74357527 NA 0.73 10.07 0.53 2.09e-20 Gestational age at birth (maternal effect); CESC cis rs992157 0.835 rs2292551 chr2:219143229 G/A cg00012203 chr2:219082015 ARPC2 -0.76 -9.55 -0.51 9.45e-19 Colorectal cancer; CESC cis rs4253772 0.575 rs9615983 chr22:46793314 G/A cg00784671 chr22:46762841 CELSR1 -0.52 -5.28 -0.31 2.63e-7 LDL cholesterol;Cholesterol, total; CESC cis rs11203032 0.831 rs11203009 chr10:90927163 G/A cg16672925 chr10:90967113 CH25H 0.74 6.99 0.39 2.26e-11 Heart failure; CESC cis rs6088580 0.634 rs6058070 chr20:33103521 G/C cg24642439 chr20:33292090 TP53INP2 0.5 6.55 0.37 3.05e-10 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24957950 chr19:39616336 PAK4 0.52 6.25 0.36 1.62e-9 Gut microbiome composition (summer); CESC trans rs347313 1.000 rs347282 chr1:162312753 G/T cg16315582 chr11:104839349 CASP4 0.43 6.13 0.35 3.24e-9 Body mass index (change over time); CESC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.42 -0.37 6.22e-10 Depression; CESC cis rs736801 0.891 rs10900809 chr5:131826322 G/A cg00255919 chr5:131827918 IRF1 -0.44 -5.74 -0.33 2.57e-8 Breast cancer;Mosquito bite size; CESC cis rs12973672 1.000 rs10405246 chr19:35768949 A/G cg12095397 chr19:35769544 USF2 0.54 7.35 0.41 2.49e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4727027 0.870 rs62507512 chr7:148799338 C/T cg23583168 chr7:148888333 NA -0.79 -12.1 -0.6 4.02e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs854765 0.583 rs8078105 chr17:17853782 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs7259376 0.905 rs2082480 chr19:22538650 G/A cg02657401 chr19:22469223 NA -0.25 -5.05 -0.3 8.16e-7 Menopause (age at onset); CESC cis rs11252926 0.545 rs11252693 chr10:532139 A/G cg03684893 chr10:554711 DIP2C -0.43 -6.88 -0.39 4.35e-11 Psychosis in Alzheimer's disease; CESC cis rs7824557 0.628 rs6988922 chr8:11194911 A/G cg21775007 chr8:11205619 TDH 0.55 8.74 0.47 2.75e-16 Retinal vascular caliber; CESC cis rs2299587 0.965 rs7843298 chr8:17806156 T/C cg08627089 chr8:17753878 FGL1 -0.38 -5.11 -0.3 6.14e-7 Economic and political preferences; CESC cis rs35306767 0.953 rs7908138 chr10:962978 C/T cg10556349 chr10:835070 NA 0.57 5.98 0.34 7.08e-9 Eosinophil percentage of granulocytes; CESC cis rs9287719 0.967 rs6735074 chr2:10734766 G/T cg02196655 chr2:10830764 NOL10 0.35 5.39 0.31 1.53e-7 Prostate cancer; CESC cis rs9303401 0.646 rs7213269 chr17:57237796 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.56 7.2 0.4 6.32e-12 Cognitive test performance; CESC cis rs6570726 0.516 rs10484700 chr6:145728933 C/T cg23711669 chr6:146136114 FBXO30 0.5 6.27 0.36 1.46e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs7539624 0.588 rs7555491 chr1:223894889 C/T cg10100437 chr1:223903862 CAPN2 -0.4 -5.07 -0.3 7.32e-7 Schizophrenia; CESC cis rs3733585 0.699 rs6834893 chr4:9959123 C/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Parkinson's disease; CESC cis rs6693567 0.565 rs12739706 chr1:150261653 C/G cg09579323 chr1:150459698 TARS2 -0.46 -5.74 -0.33 2.58e-8 Migraine; CESC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 -0.42 -5.73 -0.33 2.68e-8 Platelet count; CESC cis rs8067354 0.645 rs2665400 chr17:57880201 G/A cg02344993 chr17:57696989 CLTC 0.67 8.28 0.45 6.3e-15 Hemoglobin concentration; CESC cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg05234568 chr11:5960015 NA -0.53 -6.67 -0.38 1.48e-10 DNA methylation (variation); CESC cis rs763121 0.815 rs4821799 chr22:39021326 T/G cg06022373 chr22:39101656 GTPBP1 0.8 12.74 0.62 2.55e-29 Menopause (age at onset); CESC cis rs9309473 1.000 rs10189574 chr2:73698518 C/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.24 -0.36 1.7e-9 Metabolite levels; CESC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.77 -12.31 -0.6 7.9e-28 Personality dimensions; CESC cis rs9300255 0.722 rs67624109 chr12:123824635 C/T cg19016782 chr12:123741754 C12orf65 0.43 5.41 0.32 1.41e-7 Neutrophil percentage of white cells; CESC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg18190219 chr22:46762943 CELSR1 -0.58 -6.66 -0.38 1.6e-10 LDL cholesterol;Cholesterol, total; CESC cis rs910316 0.967 rs175502 chr14:75533679 A/G cg08847533 chr14:75593920 NEK9 -0.98 -18.49 -0.75 1.32e-49 Height; CESC trans rs6429703 0.543 rs4661562 chr1:15341251 A/G cg21586453 chr5:36239673 C5orf33 -0.6 -6.56 -0.37 2.75e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin); CESC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg24829409 chr8:58192753 C8orf71 -0.75 -10.01 -0.52 3.22e-20 Developmental language disorder (linguistic errors); CESC cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg14416269 chr4:6271139 WFS1 -0.46 -7.73 -0.43 2.2e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg12292205 chr6:26970375 C6orf41 -0.5 -5.67 -0.33 3.8e-8 Intelligence (multi-trait analysis); CESC trans rs1728785 1.000 rs7196104 chr16:68579746 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg10560079 chr2:191398806 TMEM194B -0.5 -7.26 -0.41 4.24e-12 Pulse pressure; CESC cis rs539096 0.500 rs803678 chr1:44350898 G/T cg23954153 chr1:44402353 ARTN -0.35 -5.54 -0.32 7.21e-8 Intelligence (multi-trait analysis); CESC cis rs796364 1.000 rs281771 chr2:200812202 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.79 -8.33 -0.46 4.48e-15 Schizophrenia; CESC cis rs9322193 0.566 rs4870118 chr6:150245013 G/A cg01145232 chr6:150245071 RAET1G -0.57 -7.19 -0.4 6.69e-12 Lung cancer; CESC cis rs7772486 0.875 rs2328712 chr6:146344563 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.7 0.38 1.23e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2180341 0.843 rs4895821 chr6:127572761 T/A cg27446573 chr6:127587934 RNF146 1.09 15.97 0.7 1.16e-40 Breast cancer; CESC cis rs644799 0.965 rs3016295 chr11:95554311 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 8.96 0.48 5.74e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs244293 0.965 rs8068337 chr17:53177899 T/C cg19360675 chr17:53046073 COX11;STXBP4 0.39 5.06 0.3 7.95e-7 Menarche (age at onset); CESC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg22800045 chr5:56110881 MAP3K1 -0.58 -7.38 -0.41 2.1e-12 Initial pursuit acceleration; CESC cis rs7726839 0.540 rs12520279 chr5:657291 T/C cg16447950 chr5:562315 NA -0.59 -6.46 -0.37 4.92e-10 Obesity-related traits; CESC cis rs7429990 0.901 rs6442091 chr3:48043058 T/C cg11946769 chr3:48343235 NME6 -0.5 -6.09 -0.35 4.02e-9 Educational attainment (years of education); CESC trans rs877282 0.945 rs71491311 chr10:791747 G/A cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs2228479 0.850 rs17227263 chr16:89810598 G/A cg19635926 chr16:89946313 TCF25 0.66 5.04 0.3 8.52e-7 Skin colour saturation; CESC cis rs238295 0.805 rs6116855 chr20:5555317 A/G cg24001556 chr20:5591874 RP5-1022P6.2 -0.46 -5.17 -0.3 4.58e-7 Occipital cortical area (total cortical area interaction); CESC cis rs12249377 0.519 rs7087400 chr10:92587180 A/G cg14313238 chr10:92632228 RPP30 0.43 5.26 0.31 2.92e-7 White matter microstructure (global fractional anisotropy); CESC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg03351412 chr1:154909251 PMVK 0.66 8.89 0.48 9.97e-17 Prostate cancer; CESC trans rs561341 1.000 rs535151 chr17:30317405 C/T cg20587970 chr11:113659929 NA -0.85 -10.93 -0.56 3.31e-23 Hip circumference adjusted for BMI; CESC cis rs9926296 0.533 rs12102290 chr16:89812617 C/T cg21285383 chr16:89894308 SPIRE2 0.3 5.39 0.31 1.55e-7 Vitiligo; CESC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.82 0.39 6.2e-11 Electroencephalogram traits; CESC cis rs6580649 0.941 rs12580764 chr12:48453882 G/A cg05342945 chr12:48394962 COL2A1 0.5 5.85 0.34 1.47e-8 Lung cancer; CESC cis rs2635047 0.638 rs16954921 chr18:44610526 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.66 0.33 3.87e-8 Educational attainment; CESC cis rs7524258 0.868 rs4908610 chr1:7311260 C/A cg07173049 chr1:7289937 CAMTA1 0.38 5.8 0.34 1.87e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs4716602 0.898 rs4717047 chr7:156160671 T/C cg04090468 chr7:156181990 NA 0.41 5.26 0.31 2.93e-7 Anti-saccade response; CESC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg09658497 chr7:2847517 GNA12 -0.43 -5.87 -0.34 1.27e-8 Height; CESC cis rs35146811 0.844 rs10281368 chr7:99655897 A/G cg22906224 chr7:99728672 NA 0.49 5.76 0.33 2.28e-8 Coronary artery disease; CESC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.8 0.34 1.85e-8 Tonsillectomy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11593656 chr13:76112039 COMMD6 0.54 7.16 0.4 8.18e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs921968 0.509 rs832813 chr2:219354569 T/C cg02176678 chr2:219576539 TTLL4 0.49 8.82 0.48 1.53e-16 Mean corpuscular hemoglobin concentration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06194536 chr1:220701829 MARK1 -0.51 -6.63 -0.38 1.88e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9811920 0.514 rs1287283 chr3:99515750 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.5 -5.95 -0.34 8.66e-9 Axial length; CESC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg23048001 chr7:2026167 MAD1L1 0.42 5.3 0.31 2.46e-7 Bipolar disorder and schizophrenia; CESC trans rs6479874 1.000 rs7895755 chr10:52774048 C/T cg14115756 chr9:125795935 GPR21;RABGAP1 0.66 6.07 0.35 4.31e-9 Migraine; CESC cis rs3008870 0.755 rs2755243 chr1:67482783 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.62 8.04 0.44 3.01e-14 Lymphocyte percentage of white cells; CESC trans rs16843372 0.576 rs10184397 chr2:159695242 A/T cg17808901 chr3:39093368 WDR48 0.51 6.04 0.35 5.26e-9 Obesity-related traits; CESC cis rs2228479 0.702 rs2074963 chr16:89877269 T/C cg04013166 chr16:89971882 TCF25 0.71 5.69 0.33 3.32e-8 Skin colour saturation; CESC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg17178900 chr1:205818956 PM20D1 0.79 12.65 0.61 5.03e-29 Menarche (age at onset); CESC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg03806693 chr22:41940476 POLR3H -1.05 -12.33 -0.6 6.57e-28 Vitiligo; CESC cis rs506597 0.920 rs221798 chr7:100287495 C/G cg10426581 chr7:100472382 SRRT -0.66 -5.1 -0.3 6.56e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs7408868 0.908 rs62113793 chr19:15277336 G/A cg14696996 chr19:15285081 NOTCH3 1.11 11.3 0.57 2.05e-24 Pulse pressure; CESC cis rs7129220 0.588 rs7129047 chr11:10143942 C/A cg01453529 chr11:10209919 SBF2 -0.48 -5.63 -0.33 4.67e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26074535 chr5:134094528 DDX46 -0.47 -6.1 -0.35 3.67e-9 Asthma; CESC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg26338869 chr17:61819248 STRADA 0.69 9.18 0.49 1.31e-17 Prudent dietary pattern; CESC cis rs4481887 0.741 rs6587458 chr1:248532290 T/A cg26353448 chr1:248524236 OR2T4 -0.38 -5.35 -0.31 1.9e-7 Common traits (Other); CESC cis rs7692995 1.000 rs16896271 chr4:18012454 T/C cg08925142 chr4:18023851 LCORL -0.44 -5.12 -0.3 6e-7 Height; CESC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg24642844 chr7:1081250 C7orf50 -0.78 -9.49 -0.5 1.38e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9527 0.545 rs7894588 chr10:104756030 A/T cg04362960 chr10:104952993 NT5C2 0.42 5.18 0.3 4.37e-7 Arsenic metabolism; CESC cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg27347728 chr4:17578864 LAP3 0.43 5.14 0.3 5.44e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7659604 0.540 rs4361412 chr4:122669403 C/T cg19671926 chr4:122722719 EXOSC9 0.53 6.55 0.37 3e-10 Type 2 diabetes; CESC cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg25838465 chr1:92012736 NA -0.43 -5.28 -0.31 2.72e-7 Eosinophil percentage of white cells; CESC cis rs385076 0.503 rs212702 chr2:32444250 A/G cg02381751 chr2:32503542 YIPF4 0.6 6.64 0.38 1.79e-10 Interleukin-18 levels; CESC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg11764359 chr7:65958608 NA 0.43 5.36 0.31 1.79e-7 Aortic root size; CESC cis rs763121 0.853 rs2179142 chr22:39037954 G/A cg06544989 chr22:39130855 UNC84B 0.52 9.28 0.5 6.07e-18 Menopause (age at onset); CESC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg10494973 chr17:80897199 TBCD 0.51 5.88 0.34 1.25e-8 Breast cancer; CESC cis rs6964587 1.000 rs2282975 chr7:91761638 A/G cg17063962 chr7:91808500 NA 0.58 7.97 0.44 4.71e-14 Breast cancer; CESC cis rs66573146 0.831 rs6832482 chr4:7023433 A/T cg00086871 chr4:6988644 TBC1D14 0.96 6.09 0.35 3.9e-9 Granulocyte percentage of myeloid white cells; CESC cis rs12190007 0.512 rs2984464 chr6:169837242 T/C cg15038512 chr6:170123185 PHF10 -0.51 -7.26 -0.41 4.39e-12 Obesity-related traits; CESC cis rs870825 0.616 rs1401362 chr4:185643775 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC trans rs12599106 0.715 rs34006830 chr16:34878550 C/A cg15383120 chr6:291909 DUSP22 -0.67 -8.22 -0.45 9e-15 Menopause (age at onset); CESC cis rs13385 0.769 rs13186305 chr5:139608926 C/T cg26211634 chr5:139558579 C5orf32 0.47 5.08 0.3 6.98e-7 Atrial fibrillation; CESC cis rs9596863 1.000 rs4471558 chr13:54413349 A/T ch.13.53330881F chr13:54432880 NA 0.6 5.27 0.31 2.83e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs9649465 1.000 rs13230338 chr7:123373622 T/C cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.46e-7 Migraine; CESC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg00339695 chr16:24857497 SLC5A11 0.5 6.43 0.37 5.94e-10 Intelligence (multi-trait analysis); CESC cis rs7267979 1.000 rs6083809 chr20:25329309 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.09 -0.74 3.41e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg23743428 chr13:21893420 NA -0.34 -5.84 -0.34 1.5e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC cis rs4666360 1.000 rs4666360 chr2:20335709 G/A cg23291376 chr2:20336282 NA -0.38 -6.28 -0.36 1.41e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel); CESC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.47 6.28 0.36 1.39e-9 Lymphocyte counts; CESC cis rs965469 0.779 rs6139071 chr20:3299054 A/G cg25506879 chr20:3388711 C20orf194 -0.47 -5.27 -0.31 2.89e-7 IFN-related cytopenia; CESC cis rs9894429 0.646 rs7405870 chr17:79617284 G/A cg21984481 chr17:79567631 NPLOC4 -0.34 -5.24 -0.31 3.35e-7 Eye color traits; CESC cis rs2050392 0.928 rs2250077 chr10:30702929 A/G cg18806716 chr10:30721971 MAP3K8 -0.41 -5.95 -0.34 8.61e-9 Inflammatory bowel disease; CESC trans rs10074525 0.923 rs34879738 chr5:90272197 A/G cg22855255 chr17:50237267 CA10 -0.35 -6.06 -0.35 4.65e-9 Obesity-related traits; CESC cis rs593982 0.719 rs11606668 chr11:65472758 A/G cg08755490 chr11:65554678 OVOL1 -0.83 -7.49 -0.42 1e-12 Atopic dermatitis; CESC trans rs3780486 0.801 rs10971424 chr9:33138775 T/C cg04842962 chr6:43655489 MRPS18A 1.01 19.75 0.77 5.15e-54 IgG glycosylation; CESC cis rs6032067 0.538 rs17422688 chr20:43739119 G/A cg10761708 chr20:43804764 PI3 0.45 5.07 0.3 7.44e-7 Blood protein levels; CESC cis rs3008870 1.000 rs4655663 chr1:67430103 C/T cg02640540 chr1:67518911 SLC35D1 0.52 5.69 0.33 3.28e-8 Lymphocyte percentage of white cells; CESC cis rs1008375 0.866 rs2109518 chr4:17572162 G/A cg02297831 chr4:17616191 MED28 0.5 6.1 0.35 3.84e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4423214 0.840 rs3794057 chr11:71186744 G/A cg05163923 chr11:71159392 DHCR7 -0.68 -7.76 -0.43 1.82e-13 Vitamin D levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18387343 chr1:27248345 NUDC 0.58 6.42 0.37 6.09e-10 Gut microbiome composition (summer); CESC cis rs6489785 0.687 rs3213567 chr12:121222556 T/C cg02419362 chr12:121203948 SPPL3 0.36 5.87 0.34 1.27e-8 Longevity;Allergic disease (asthma, hay fever or eczema); CESC cis rs12681288 0.754 rs4735975 chr8:1000470 T/C cg04851639 chr8:1020857 NA -0.32 -7.17 -0.4 7.66e-12 Schizophrenia; CESC cis rs5753618 0.607 rs5753621 chr22:31847647 T/C cg00478049 chr22:31556069 RNF185 -0.43 -5.08 -0.3 6.98e-7 Colorectal cancer; CESC cis rs2735413 0.918 rs34094825 chr16:78081392 G/C cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs3105593 0.555 rs3131568 chr15:50757721 C/T cg05456662 chr15:50716270 USP8 0.39 5.28 0.31 2.73e-7 QT interval; CESC cis rs9811920 0.638 rs1688782 chr3:99630527 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.52 -6.58 -0.37 2.49e-10 Axial length; CESC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg15145296 chr3:125709740 NA -0.5 -5.26 -0.31 3.01e-7 Blood pressure (smoking interaction); CESC cis rs8018808 0.905 rs11622359 chr14:77939449 C/T cg20045696 chr14:77926864 AHSA1 -0.43 -5.93 -0.34 9.43e-9 Myeloid white cell count; CESC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg11644478 chr21:40555479 PSMG1 -0.55 -7.52 -0.42 8.26e-13 Menarche (age at onset); CESC cis rs9291683 0.546 rs6820188 chr4:10051655 C/T cg02734326 chr4:10020555 SLC2A9 0.46 6.55 0.37 3e-10 Bone mineral density; CESC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg11764359 chr7:65958608 NA 0.89 13.78 0.65 6.18e-33 Aortic root size; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg04159488 chr11:64578146 MEN1 -0.46 -6.11 -0.35 3.49e-9 Recombination measurement; CESC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.7 -9.31 -0.5 5.15e-18 Mean platelet volume; CESC cis rs2228479 0.717 rs34027607 chr16:89808939 T/C cg04013166 chr16:89971882 TCF25 0.72 7.87 0.44 9.3e-14 Skin colour saturation; CESC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg15145296 chr3:125709740 NA -0.53 -5.67 -0.33 3.82e-8 Blood pressure (smoking interaction); CESC cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg02487422 chr3:49467188 NICN1 0.4 5.15 0.3 5.11e-7 Parkinson's disease; CESC cis rs10504229 0.593 rs1442127 chr8:57992136 T/C cg24829409 chr8:58192753 C8orf71 -0.49 -5.88 -0.34 1.21e-8 Developmental language disorder (linguistic errors); CESC cis rs4704187 0.687 rs6453111 chr5:74379926 C/T cg03227963 chr5:74354835 NA 0.32 5.95 0.34 8.68e-9 Response to amphetamines; CESC trans rs9929218 1.000 rs13330350 chr16:68800849 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.44 -0.46 2.13e-15 Colorectal cancer; CESC cis rs3845702 0.736 rs6433816 chr2:180809317 G/C cg01881094 chr2:180872142 CWC22 -1.05 -8.97 -0.48 5.56e-17 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14819942 chr15:35414228 NA -0.47 -6.65 -0.38 1.67e-10 Gut microbiota (bacterial taxa); CESC trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21582582 chr3:182698605 DCUN1D1 -0.44 -6.01 -0.35 6.18e-9 Intelligence (multi-trait analysis); CESC trans rs877282 0.583 rs11253441 chr10:828288 C/T cg22713356 chr15:30763199 NA -1.04 -9.6 -0.51 6.21e-19 Uric acid levels; CESC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.71 0.33 3.07e-8 Menopause (age at onset); CESC cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2635047 0.904 rs2635046 chr18:44728429 G/A cg19077165 chr18:44547161 KATNAL2 -0.41 -5.67 -0.33 3.73e-8 Educational attainment; CESC cis rs870825 0.616 rs7682505 chr4:185640648 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs933688 1.000 rs889213 chr5:90682151 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.87 0.59 2.36e-26 Smoking behavior; CESC cis rs67072384 1.000 rs2365441 chr11:72450226 T/C cg04827223 chr11:72435913 ARAP1 -0.71 -6.85 -0.39 5e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs9911578 0.835 rs9904993 chr17:56468569 G/T cg05425664 chr17:57184151 TRIM37 0.45 6.29 0.36 1.27e-9 Intelligence (multi-trait analysis); CESC cis rs55794721 0.509 rs12027135 chr1:25775733 A/T cg02931644 chr1:25747376 RHCE 0.43 7.2 0.4 6.14e-12 Plateletcrit;Mean corpuscular volume; CESC cis rs9611565 0.649 rs9623450 chr22:42175231 G/A cg06634786 chr22:41940651 POLR3H 0.46 5.06 0.3 7.69e-7 Vitiligo; CESC cis rs9486719 0.948 rs2472906 chr6:96875318 G/T cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs9583531 0.527 rs6492302 chr13:111352354 C/T cg15841412 chr13:111365552 ING1 -0.49 -6.44 -0.37 5.67e-10 Coronary artery disease; CESC cis rs7623687 1.000 rs7623687 chr3:49448566 A/C cg07274523 chr3:49395745 GPX1 0.64 5.58 0.32 5.83e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CESC cis rs2249625 0.584 rs2496506 chr6:72891324 A/C cg18830697 chr6:72922368 RIMS1 -0.47 -7.02 -0.4 1.89e-11 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7481584 0.624 rs375579 chr11:3065300 G/C cg25174290 chr11:3078921 CARS -0.53 -7.36 -0.41 2.32e-12 Calcium levels; CESC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg05872129 chr22:39784769 NA -0.84 -11.54 -0.58 3.09e-25 Intelligence (multi-trait analysis); CESC cis rs3026445 0.832 rs7975364 chr12:110602275 A/T cg12870014 chr12:110450643 ANKRD13A 0.46 6.0 0.35 6.59e-9 QT interval; CESC cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg14784868 chr12:69753453 YEATS4 0.83 12.99 0.62 3.47e-30 Blood protein levels; CESC cis rs66530629 0.874 rs6604978 chr1:25090446 C/G cg22509179 chr1:25234806 RUNX3 -0.43 -5.48 -0.32 9.73e-8 Plateletcrit; CESC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg11965913 chr1:205819406 PM20D1 0.81 13.33 0.63 2.2e-31 Menarche (age at onset); CESC cis rs2276314 0.857 rs8097597 chr18:33619448 A/G cg05985134 chr18:33552581 C18orf21 0.58 7.18 0.4 7.18e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs1801251 0.929 rs10933409 chr2:233629386 A/G cg08000102 chr2:233561755 GIGYF2 0.67 9.48 0.5 1.53e-18 Coronary artery disease; CESC cis rs9911578 1.000 rs304292 chr17:56824123 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.21 0.3 3.88e-7 Intelligence (multi-trait analysis); CESC cis rs11250464 0.833 rs2387653 chr10:1407826 A/G cg08668359 chr10:1443807 ADARB2 -0.56 -6.6 -0.38 2.18e-10 Radiation response; CESC cis rs5758511 0.514 rs2899354 chr22:42554409 G/T cg00645731 chr22:42541494 CYP2D7P1 0.6 8.89 0.48 9.89e-17 Birth weight; CESC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg04267008 chr7:1944627 MAD1L1 -0.63 -7.72 -0.43 2.43e-13 Bipolar disorder and schizophrenia; CESC trans rs1447537 0.683 rs28819387 chr2:84213355 G/C cg03726739 chr5:168254759 SLIT3 0.43 6.08 0.35 4.12e-9 RR interval (heart rate); CESC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg06873352 chr17:61820015 STRADA 0.48 6.95 0.39 2.8e-11 Height; CESC cis rs6430585 0.527 rs2304366 chr2:136467119 C/T cg07169764 chr2:136633963 MCM6 1.09 12.44 0.61 2.64e-28 Corneal structure; CESC cis rs62408225 1.000 rs62408233 chr6:90976609 G/A cg06866423 chr6:90926672 BACH2 0.43 5.18 0.3 4.38e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.74 10.73 0.55 1.58e-22 Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16487280 chr20:42295503 MYBL2 0.56 6.6 0.38 2.28e-10 Gut microbiome composition (summer); CESC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg18230493 chr5:56204884 C5orf35 0.61 7.98 0.44 4.33e-14 Initial pursuit acceleration; CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg11905131 chr22:24372483 LOC391322 -0.78 -11.7 -0.58 9.3e-26 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs66573146 0.831 rs67602077 chr4:7024244 A/G cg07817883 chr1:32538562 TMEM39B 1.15 6.88 0.39 4.22e-11 Granulocyte percentage of myeloid white cells; CESC cis rs524281 0.682 rs6591202 chr11:65806093 T/A cg14036092 chr11:66035641 RAB1B 0.5 5.08 0.3 7.08e-7 Electroencephalogram traits; CESC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg27211696 chr2:191398769 TMEM194B -0.53 -8.0 -0.44 3.94e-14 Pulse pressure; CESC cis rs1707322 1.000 rs785468 chr1:46521517 G/A cg03146154 chr1:46216737 IPP -0.72 -9.73 -0.51 2.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg04248312 chr19:17393744 ANKLE1 -0.92 -14.85 -0.67 1.01e-36 Systemic lupus erythematosus; CESC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg22535103 chr8:58192502 C8orf71 -1.02 -11.22 -0.57 3.61e-24 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg26338869 chr17:61819248 STRADA -0.61 -7.99 -0.44 4.05e-14 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18489012 chr6:36561954 SFRS3 0.53 6.02 0.35 5.9e-9 Gut microbiome composition (summer); CESC cis rs11166927 1.000 rs12549587 chr8:140804310 G/A cg16909799 chr8:140841666 TRAPPC9 0.61 8.85 0.48 1.31e-16 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs6570726 0.967 rs403584 chr6:145807010 G/A cg05347473 chr6:146136440 FBXO30 0.43 5.82 0.34 1.74e-8 Lobe attachment (rater-scored or self-reported); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08305803 chr16:28565427 CCDC101 -0.51 -6.02 -0.35 5.74e-9 Ulcerative colitis; CESC cis rs7772486 0.875 rs7766595 chr6:146364507 A/T cg05347473 chr6:146136440 FBXO30 0.47 6.16 0.35 2.66e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg25174290 chr11:3078921 CARS 0.56 7.39 0.41 1.95e-12 Longevity; CESC trans rs1493916 1.000 rs7238717 chr18:31395186 C/T cg27147174 chr7:100797783 AP1S1 -0.52 -7.06 -0.4 1.45e-11 Life satisfaction; CESC cis rs6964587 1.000 rs10236397 chr7:91691601 C/T cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.45e-15 Breast cancer; CESC cis rs11098499 0.731 rs9995026 chr4:120490499 T/A cg09307838 chr4:120376055 NA 0.9 12.28 0.6 9.3e-28 Corneal astigmatism; CESC cis rs7914558 0.966 rs11191438 chr10:104637864 C/G cg04362960 chr10:104952993 NT5C2 0.49 6.66 0.38 1.55e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7191439 0.858 rs2340973 chr16:88773396 G/A cg02389323 chr16:88786976 FAM38A 0.97 7.74 0.43 2.13e-13 Plateletcrit; CESC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.82 0.62 1.39e-29 Alzheimer's disease; CESC cis rs2228479 0.850 rs17232630 chr16:89851179 C/T cg14709524 chr16:89940631 TCF25 0.94 7.05 0.4 1.57e-11 Skin colour saturation; CESC cis rs7191439 0.722 rs6500491 chr16:88783521 T/C cg27087555 chr16:88793112 FAM38A -1.22 -9.32 -0.5 4.71e-18 Plateletcrit; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09431544 chr19:14629187 DNAJB1 -0.5 -6.73 -0.38 1.06e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg08888203 chr3:10149979 C3orf24 0.48 6.09 0.35 3.99e-9 Alzheimer's disease; CESC cis rs2795502 0.882 rs3123754 chr10:43339011 G/A cg20628663 chr10:43360327 NA -0.63 -7.47 -0.42 1.16e-12 Blood protein levels; CESC trans rs1814175 0.645 rs10839456 chr11:49964093 C/T cg15704280 chr7:45808275 SEPT13 -0.98 -18.56 -0.75 7.41e-50 Height; CESC cis rs17401966 0.931 rs4846213 chr1:10399178 A/G cg15208524 chr1:10270712 KIF1B 0.43 5.48 0.32 1e-7 Hepatocellular carcinoma; CESC cis rs17490626 0.568 rs2033371 chr10:71212310 G/A cg12610070 chr10:71211762 TSPAN15 -0.31 -6.62 -0.38 1.98e-10 Thrombosis; CESC cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg19077165 chr18:44547161 KATNAL2 -0.51 -7.31 -0.41 3.17e-12 Personality dimensions; CESC cis rs367943 0.608 rs4705463 chr5:112980273 C/G cg12552261 chr5:112820674 MCC 0.39 5.03 0.3 8.99e-7 Type 2 diabetes; CESC cis rs2243480 1.000 rs67728539 chr7:65378124 G/A cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC cis rs11577318 0.853 rs12743998 chr1:26629882 G/A cg19743891 chr1:26644573 UBXN11;CD52 -0.28 -5.11 -0.3 6.05e-7 Granulocyte percentage of myeloid white cells; CESC cis rs10789491 1.000 rs601060 chr1:47139580 C/G cg15501359 chr1:47185051 KIAA0494 -0.81 -8.79 -0.48 1.86e-16 Response to hepatitis C treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03602124 chr1:113258101 PPM1J 0.52 6.19 0.36 2.28e-9 Gut microbiome composition (summer); CESC cis rs7833986 0.501 rs2953922 chr8:56977485 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 6.89e-13 Height; CESC cis rs6815814 0.731 rs4513579 chr4:38773816 T/C cg02016764 chr4:38805732 TLR1 -0.44 -6.08 -0.35 4.24e-9 Breast cancer; CESC cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg19717773 chr7:2847554 GNA12 -0.5 -7.61 -0.42 4.85e-13 Height; CESC cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg23711669 chr6:146136114 FBXO30 -0.82 -9.94 -0.52 5.52e-20 Lobe attachment (rater-scored or self-reported); CESC trans rs722599 0.748 rs17093914 chr14:75363641 A/G cg00095594 chr1:236228625 NID1 0.41 6.32 0.36 1.13e-9 IgG glycosylation; CESC cis rs11214589 0.875 rs10891540 chr11:113239082 A/G cg14159747 chr11:113255604 NA -0.28 -5.1 -0.3 6.56e-7 Neuroticism; CESC cis rs763014 0.865 rs4006748 chr16:632225 T/C cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC cis rs4604732 0.536 rs7528219 chr1:247628307 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 6.01 0.35 6.07e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs10751667 1.000 rs6597965 chr11:964476 A/G cg20946044 chr11:1010712 AP2A2 -0.42 -5.66 -0.33 3.95e-8 Alzheimer's disease (late onset); CESC cis rs4472734 0.965 rs4535974 chr1:214628958 A/G cg00063699 chr1:214624242 PTPN14 -0.33 -5.04 -0.3 8.73e-7 Height; CESC cis rs10870270 1.000 rs11146324 chr10:133767445 A/C cg26149184 chr10:133730230 NA 0.37 5.1 0.3 6.42e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs9902453 0.967 rs4994355 chr17:28386284 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.6 -7.56 -0.42 6.56e-13 Coffee consumption (cups per day); CESC cis rs826838 0.616 rs2387921 chr12:38624767 T/C cg26384229 chr12:38710491 ALG10B -0.43 -5.65 -0.33 4.09e-8 Heart rate; CESC cis rs13102973 0.965 rs28874134 chr4:135867088 C/A cg14419869 chr4:135874104 NA -0.4 -6.29 -0.36 1.32e-9 Subjective well-being; CESC cis rs7923609 0.841 rs7920036 chr10:65293860 T/C cg01631684 chr10:65280961 REEP3 -0.44 -5.52 -0.32 8.13e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs6952808 0.743 rs4719308 chr7:1877502 T/G cg24247370 chr13:99142703 STK24 -0.42 -6.27 -0.36 1.45e-9 Bipolar disorder and schizophrenia; CESC cis rs4595586 0.505 rs11611321 chr12:39390803 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs1256061 0.624 rs1760988 chr14:64696813 A/G cg21174375 chr14:64681225 SYNE2 0.48 6.36 0.36 8.86e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7580658 0.963 rs867304 chr2:128078488 G/A cg10021288 chr2:128175891 PROC -0.41 -6.49 -0.37 4.24e-10 Protein C levels; CESC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 8.31 0.45 4.9e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9549367 0.756 rs3861723 chr13:113910926 A/G cg18105134 chr13:113819100 PROZ -0.62 -7.9 -0.44 7.32e-14 Platelet distribution width; CESC cis rs10504229 0.679 rs72649107 chr8:58030453 C/A cg24829409 chr8:58192753 C8orf71 -0.44 -5.73 -0.33 2.75e-8 Developmental language disorder (linguistic errors); CESC cis rs9902453 0.845 rs3102559 chr17:28029723 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.53 0.46 1.15e-15 Coffee consumption (cups per day); CESC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg25811766 chr13:21894605 NA 0.56 5.65 0.33 4.1e-8 White matter hyperintensity burden; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg16145915 chr7:1198662 ZFAND2A -0.73 -11.94 -0.59 1.35e-26 Longevity;Endometriosis; CESC cis rs10242455 0.764 rs2740561 chr7:99321441 G/A cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC trans rs78472555 0.661 rs2570934 chr15:100143999 A/T cg17514665 chr17:1657533 SERPINF2 -0.46 -6.17 -0.35 2.52e-9 Post bronchodilator FEV1/FVC ratio in COPD; CESC cis rs4268898 0.662 rs59996104 chr2:24404064 C/T cg06627628 chr2:24431161 ITSN2 -0.97 -9.78 -0.51 1.78e-19 Asthma; CESC cis rs832540 0.656 rs702689 chr5:56177443 G/A cg22800045 chr5:56110881 MAP3K1 0.44 5.29 0.31 2.58e-7 Coronary artery disease; CESC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg17376030 chr22:41985996 PMM1 -0.77 -8.07 -0.44 2.39e-14 Cannabis dependence symptom count; CESC cis rs2439831 0.681 rs1095386 chr15:43609509 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.8 0.55 8.69e-23 Lung cancer in ever smokers; CESC cis rs7131987 0.868 rs737160 chr12:29429012 T/C cg09582351 chr12:29534625 ERGIC2 -0.31 -5.19 -0.3 4.26e-7 QT interval; CESC cis rs67311347 0.822 rs11709089 chr3:40351484 C/T cg24209194 chr3:40518798 ZNF619 0.4 5.06 0.3 7.99e-7 Renal cell carcinoma; CESC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg16325326 chr1:53192061 ZYG11B -0.89 -15.49 -0.69 5.54e-39 Monocyte count; CESC cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg20476274 chr7:133979776 SLC35B4 0.69 10.2 0.53 8.1899999999999992e-21 Mean platelet volume; CESC cis rs2455799 0.613 rs12485852 chr3:15914511 G/C cg09340198 chr3:15902540 ANKRD28 -0.32 -5.1 -0.3 6.52e-7 Mean platelet volume; CESC cis rs12579753 0.917 rs10862375 chr12:82254809 C/G cg24719984 chr12:82153464 PPFIA2 0.36 5.46 0.32 1.11e-7 Resting heart rate; CESC cis rs10979 0.597 rs9321927 chr6:143913295 A/G cg25407410 chr6:143891975 LOC285740 0.47 6.3 0.36 1.2e-9 Hypospadias; CESC cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg12350822 chr6:88032061 C6orf162;GJB7 0.5 8.64 0.47 5.32e-16 Monocyte percentage of white cells; CESC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.66 0.38 1.57e-10 Prudent dietary pattern; CESC cis rs4843747 0.519 rs12599755 chr16:88107006 A/G cg17633681 chr16:88106987 BANP 0.71 9.39 0.5 2.89e-18 Menopause (age at onset); CESC cis rs72781680 1.000 rs72781667 chr2:24225667 A/G cg08917208 chr2:24149416 ATAD2B 1.02 8.9 0.48 9.29e-17 Lymphocyte counts; CESC cis rs9291683 0.507 rs3796837 chr4:10011321 C/G cg11266682 chr4:10021025 SLC2A9 0.67 13.0 0.62 3.08e-30 Bone mineral density; CESC cis rs6088590 1.000 rs6120708 chr20:33335526 G/A cg08999081 chr20:33150536 PIGU 0.58 8.84 0.48 1.37e-16 Coronary artery disease; CESC cis rs2204008 0.693 rs12372025 chr12:38202028 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.48 0.54 9.85e-22 Bladder cancer; CESC cis rs7818688 0.745 rs73271178 chr8:95907230 C/T cg16049864 chr8:95962084 TP53INP1 0.55 5.38 0.31 1.63e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs67311347 1.000 rs6793596 chr3:40457795 C/T cg09455208 chr3:40491958 NA 0.53 8.84 0.48 1.37e-16 Renal cell carcinoma; CESC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg10253484 chr15:75165896 SCAMP2 -0.55 -7.3 -0.41 3.32e-12 Breast cancer; CESC trans rs9467711 0.659 rs36033628 chr6:26456074 T/G cg01620082 chr3:125678407 NA -0.86 -6.47 -0.37 4.66e-10 Autism spectrum disorder or schizophrenia; CESC cis rs3026101 0.671 rs28619210 chr17:5319053 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.22 0.31 3.64e-7 Body mass index; CESC cis rs7937682 0.883 rs510388 chr11:111451869 G/T cg22437258 chr11:111473054 SIK2 -0.63 -8.39 -0.46 2.94e-15 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23845507 chr1:91966731 CDC7 0.74 8.12 0.45 1.74e-14 Gut microbiome composition (summer); CESC cis rs12681366 0.762 rs1598713 chr8:95381289 G/T cg13257157 chr8:95487014 RAD54B 0.38 5.15 0.3 5.09e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08473553 chr1:236304799 GPR137B -0.49 -6.12 -0.35 3.34e-9 Ulcerative colitis; CESC cis rs614226 0.935 rs7137953 chr12:120894685 C/T cg01236616 chr12:121019343 POP5 -1.39 -15.84 -0.7 3.24e-40 Type 1 diabetes nephropathy; CESC cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg05347473 chr6:146136440 FBXO30 0.59 7.63 0.42 4.24e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7091068 0.522 rs10882322 chr10:95483273 C/G cg20715218 chr10:95462985 C10orf4 0.5 5.89 0.34 1.14e-8 Urinary tract infection frequency; CESC cis rs10267417 0.514 rs2072184 chr7:19748883 A/G cg05791153 chr7:19748676 TWISTNB 0.86 9.13 0.49 1.75e-17 Night sleep phenotypes; CESC cis rs17253792 0.822 rs77033617 chr14:56129746 T/A cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.24e-8 Lung cancer; CESC cis rs6831352 0.918 rs2851246 chr4:100046104 A/G cg12011299 chr4:100065546 ADH4 0.58 6.61 0.38 2.12e-10 Alcohol dependence; CESC cis rs854765 0.663 rs12941550 chr17:17753828 C/A cg16928487 chr17:17741425 SREBF1 0.63 11.68 0.58 1.05e-25 Total body bone mineral density; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00352397 chr1:45477801 UROD;HECTD3 0.47 6.15 0.35 2.87e-9 Systemic lupus erythematosus; CESC cis rs727505 0.954 rs59283092 chr7:124678282 T/C cg23710748 chr7:124431027 NA -0.41 -6.39 -0.37 7.48e-10 Lewy body disease; CESC cis rs9549260 0.753 rs2297628 chr13:41233905 T/C cg21288729 chr13:41239152 FOXO1 0.54 5.33 0.31 2.11e-7 Red blood cell count; CESC cis rs9894429 0.700 rs113915083 chr17:79552696 G/C cg13777783 chr17:79615861 NA 0.32 5.07 0.3 7.39e-7 Eye color traits; CESC cis rs2712184 0.756 rs2712181 chr2:217654869 C/T cg05032264 chr2:217675019 NA 0.36 5.54 0.32 7.32e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC cis rs7267979 1.000 rs6083862 chr20:25411086 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.8 -16.6 -0.71 6.7e-43 Liver enzyme levels (alkaline phosphatase); CESC trans rs7839040 0.698 rs10102209 chr8:82926791 A/G cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs5753037 0.653 rs140121 chr22:30138689 C/T cg01021169 chr22:30184971 ASCC2 -0.44 -6.12 -0.35 3.3e-9 Type 1 diabetes; CESC cis rs9912789 0.744 rs9893755 chr17:79187432 C/T cg25342872 chr17:79175132 AZI1 0.51 6.29 0.36 1.3e-9 Frontotemporal dementia; CESC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.36 -0.36 8.66e-10 Depression; CESC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg24531977 chr5:56204891 C5orf35 -0.87 -10.91 -0.56 3.87e-23 Initial pursuit acceleration; CESC cis rs11785400 1.000 rs7002932 chr8:143738816 C/A cg10596483 chr8:143751796 JRK 0.43 5.65 0.33 4.1e-8 Schizophrenia; CESC cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg15485101 chr11:133734466 NA 0.41 6.55 0.37 3.06e-10 Childhood ear infection; CESC cis rs3020736 0.500 rs4147638 chr22:42487900 G/A cg15557168 chr22:42548783 NA 0.44 6.25 0.36 1.6e-9 Autism spectrum disorder or schizophrenia; CESC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg21548813 chr6:291882 DUSP22 -0.74 -10.17 -0.53 1.01e-20 Menopause (age at onset); CESC cis rs16854884 1.000 rs7649614 chr3:143789028 G/A cg06585982 chr3:143692056 C3orf58 0.48 5.45 0.32 1.13e-7 Economic and political preferences (feminism/equality); CESC cis rs9303401 0.659 rs12952325 chr17:56899371 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.5 0.61 1.71e-28 Cognitive test performance; CESC cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg13798912 chr7:905769 UNC84A -0.52 -5.27 -0.31 2.8e-7 Cerebrospinal P-tau181p levels; CESC cis rs5769765 0.658 rs2157536 chr22:50190180 G/A cg02269571 chr22:50332266 NA -0.46 -5.97 -0.34 7.67e-9 Schizophrenia; CESC cis rs10883723 0.810 rs6584504 chr10:104253507 T/C cg22532475 chr10:104410764 TRIM8 -0.34 -5.71 -0.33 2.98e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg08704611 chr17:80376099 HEXDC;C17orf101 -0.44 -5.13 -0.3 5.54e-7 Breast cancer; CESC cis rs7091068 1.000 rs7091068 chr10:95420385 G/T cg20715218 chr10:95462985 C10orf4 0.57 5.22 0.31 3.56e-7 Urinary tract infection frequency; CESC cis rs5753618 0.555 rs5749291 chr22:31907523 C/G cg00478049 chr22:31556069 RNF185 -0.46 -5.52 -0.32 7.99e-8 Colorectal cancer; CESC cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg05343316 chr1:45956843 TESK2 -0.51 -6.57 -0.37 2.7e-10 High light scatter reticulocyte count; CESC cis rs2932538 0.614 rs6537741 chr1:113085175 A/C cg22162597 chr1:113214053 CAPZA1 -0.56 -6.78 -0.38 7.79e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs9875589 0.509 rs2733548 chr3:14094478 C/T cg19554555 chr3:13937349 NA -0.46 -5.98 -0.35 7.03e-9 Ovarian reserve; CESC cis rs11971779 0.793 rs11543827 chr7:139032693 G/A cg07862535 chr7:139043722 LUC7L2 0.51 5.65 0.33 4.17e-8 Diisocyanate-induced asthma; CESC cis rs12586317 0.513 rs74564132 chr14:35472882 C/T cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC trans rs8073060 0.586 rs226089 chr17:34016935 C/T cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg16006841 chr5:176797999 RGS14 0.43 5.17 0.3 4.68e-7 Hemoglobin concentration;Hematocrit; CESC cis rs4722166 0.508 rs1474347 chr7:22768124 A/C cg05265849 chr7:22767390 IL6 -0.43 -5.75 -0.33 2.51e-8 Lung cancer; CESC cis rs17021463 0.902 rs36099342 chr4:95239783 T/C cg11021082 chr4:95130006 SMARCAD1 0.53 7.96 0.44 4.97e-14 Testicular germ cell tumor; CESC cis rs6912958 0.781 rs9450752 chr6:88300013 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.58 -0.37 2.55e-10 Monocyte percentage of white cells; CESC cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg20476274 chr7:133979776 SLC35B4 0.65 9.41 0.5 2.53e-18 Mean platelet volume; CESC cis rs2439831 0.867 rs2927072 chr15:43922398 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.71 8.69 0.47 3.81e-16 Lung cancer in ever smokers; CESC cis rs4730250 0.707 rs1981696 chr7:106794100 C/T cg02696742 chr7:106810147 HBP1 0.55 5.35 0.31 1.87e-7 Osteoarthritis; CESC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg27170947 chr2:26402098 FAM59B 0.66 7.91 0.44 6.83e-14 Gut microbiome composition (summer); CESC cis rs4919087 0.705 rs701812 chr10:98975413 A/G cg25902810 chr10:99078978 FRAT1 -0.45 -5.2 -0.3 3.96e-7 Monocyte count; CESC cis rs12822507 0.868 rs12580006 chr12:12789646 C/T cg11838227 chr12:12764436 CREBL2 -0.41 -5.43 -0.32 1.25e-7 Systemic lupus erythematosus; CESC cis rs72781680 1.000 rs7578969 chr2:24168620 T/C cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs213032 0.958 rs213036 chr1:21655345 T/C cg16416158 chr1:21652298 ECE1 0.33 5.39 0.31 1.57e-7 Obesity-related traits; CESC cis rs7208859 0.524 rs8069400 chr17:29075967 G/T cg13385521 chr17:29058706 SUZ12P 0.82 6.58 0.37 2.48e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6460942 1.000 rs62448568 chr7:12407445 A/G cg06484146 chr7:12443880 VWDE -0.8 -9.01 -0.48 4.07e-17 Coronary artery disease; CESC cis rs16922576 0.656 rs2093448 chr9:5230444 T/G cg02405213 chr9:5042618 JAK2 -0.51 -6.18 -0.35 2.46e-9 Allergic disease (asthma, hay fever or eczema); CESC trans rs10488023 0.649 rs73119923 chr7:36925535 T/C cg21282997 chr2:103035835 IL18RAP 0.39 6.13 0.35 3.26e-9 Breast size; CESC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg01416388 chr22:39784598 NA -0.58 -7.27 -0.41 4.15e-12 Intelligence (multi-trait analysis); CESC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg19622623 chr12:86230825 RASSF9 -0.47 -5.95 -0.34 8.32e-9 Major depressive disorder; CESC cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.6 -8.73 -0.47 2.88e-16 Personality dimensions; CESC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg14558114 chr2:88469736 THNSL2 0.59 5.56 0.32 6.52e-8 Plasma clusterin levels; CESC cis rs34779708 0.702 rs4007272 chr10:35546859 T/G cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs561341 1.000 rs550264 chr17:30317540 G/T cg19193384 chr17:30244184 NA -0.69 -6.51 -0.37 3.73e-10 Hip circumference adjusted for BMI; CESC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg27286337 chr10:134555280 INPP5A -0.69 -7.98 -0.44 4.35e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9287719 0.967 rs7587231 chr2:10740093 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs2204008 0.837 rs7974888 chr12:37945215 A/G cg26384229 chr12:38710491 ALG10B 0.67 9.77 0.51 1.9e-19 Bladder cancer; CESC cis rs11122272 0.705 rs2491411 chr1:231533448 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs1401999 1.000 rs6800217 chr3:183685893 T/C cg01324343 chr3:183735012 ABCC5 0.62 13.06 0.63 1.92e-30 Anterior chamber depth; CESC cis rs2603127 0.768 rs13321325 chr3:108456798 A/G cg03329597 chr3:108125523 MYH15 -0.54 -5.08 -0.3 7.07e-7 Hemostatic factors and hematological phenotypes; CESC cis rs10911251 0.508 rs944970 chr1:183112566 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.22 0.63 5.53e-31 Colorectal cancer; CESC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg18876405 chr7:65276391 NA 0.5 6.64 0.38 1.75e-10 Aortic root size; CESC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.5 0.37 3.88e-10 Electroencephalogram traits; CESC cis rs654950 0.840 rs647146 chr1:41986286 G/A cg06885757 chr1:42089581 HIVEP3 0.42 6.65 0.38 1.66e-10 Airway imaging phenotypes; CESC cis rs965469 0.779 rs6051746 chr20:3307290 C/G cg25506879 chr20:3388711 C20orf194 -0.53 -5.7 -0.33 3.12e-8 IFN-related cytopenia; CESC cis rs7312774 0.881 rs1822737 chr12:107309175 A/G cg16260113 chr12:107380972 MTERFD3 0.63 5.94 0.34 8.71e-9 Severe influenza A (H1N1) infection; CESC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.48 6.69 0.38 1.36e-10 Menopause (age at onset); CESC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg18016565 chr1:150552671 MCL1 0.34 5.07 0.3 7.35e-7 Melanoma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03178185 chr16:71758038 NA -0.49 -7.09 -0.4 1.25e-11 Gambling; CESC cis rs5758659 0.714 rs2413668 chr22:42505841 G/A cg19513890 chr22:42538836 CYP2D7P1 0.36 5.37 0.31 1.74e-7 Cognitive function; CESC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg17971929 chr21:40555470 PSMG1 -0.87 -12.35 -0.6 5.7e-28 Cognitive function; CESC cis rs11785400 0.793 rs4736366 chr8:143742413 C/T cg10596483 chr8:143751796 JRK 0.46 5.75 0.33 2.43e-8 Schizophrenia; CESC cis rs2952156 0.920 rs2517958 chr17:37838751 G/A cg00129232 chr17:37814104 STARD3 -0.82 -12.14 -0.6 2.94e-27 Asthma; CESC cis rs9309711 0.560 rs6548164 chr2:3472665 C/T cg10845886 chr2:3471009 TTC15 0.58 7.94 0.44 5.58e-14 Neurofibrillary tangles; CESC cis rs1008375 1.000 rs2315556 chr4:17670861 T/C cg02297831 chr4:17616191 MED28 0.45 5.68 0.33 3.53e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4561483 0.801 rs33660 chr16:11961858 A/G cg08843971 chr16:11963173 GSPT1 -0.56 -8.18 -0.45 1.18e-14 Testicular germ cell tumor; CESC cis rs116095464 0.558 rs10055354 chr5:243794 G/A cg20965017 chr5:231967 SDHA -0.47 -5.38 -0.31 1.65e-7 Breast cancer; CESC cis rs362272 0.545 rs2236052 chr4:3318413 C/T cg08886695 chr4:3369023 RGS12 0.4 5.52 0.32 8.03e-8 Serum sulfate level; CESC cis rs7179456 0.513 rs640704 chr15:59049021 A/G cg05156742 chr15:59063176 FAM63B 0.63 8.22 0.45 9.04e-15 Asperger disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22271113 chr17:8370397 NDEL1 -0.55 -6.17 -0.35 2.51e-9 Gut microbiome composition (summer); CESC cis rs7107174 1.000 rs2510040 chr11:77944548 T/A cg03754400 chr11:77348600 CLNS1A 0.49 5.19 0.3 4.16e-7 Testicular germ cell tumor; CESC cis rs7539542 0.556 rs10753925 chr1:202854488 C/T cg19681188 chr1:202830198 LOC148709 0.41 5.29 0.31 2.56e-7 Mean platelet volume; CESC cis rs4969178 0.896 rs1976704 chr17:76401318 C/T cg05887092 chr17:76393375 PGS1 0.58 9.26 0.49 7e-18 HDL cholesterol levels; CESC cis rs3540 0.513 rs2601154 chr15:90894284 T/C cg22089800 chr15:90895588 ZNF774 0.73 10.0 0.52 3.46e-20 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9611565 0.605 rs202638 chr22:41855458 A/G cg06481639 chr22:41940642 POLR3H 0.51 5.77 0.33 2.22e-8 Vitiligo; CESC cis rs8020095 0.571 rs728647 chr14:67378055 G/T cg19548862 chr14:67692701 FAM71D -0.49 -6.03 -0.35 5.38e-9 Depression (quantitative trait); CESC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg08859206 chr1:53392774 SCP2 -0.55 -7.24 -0.41 4.76e-12 Monocyte count; CESC cis rs8072100 0.688 rs8075843 chr17:45442363 C/T cg08085267 chr17:45401833 C17orf57 -0.53 -6.65 -0.38 1.65e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6088580 0.634 rs6088483 chr20:32984714 T/A cg08999081 chr20:33150536 PIGU -0.65 -11.34 -0.57 1.5e-24 Glomerular filtration rate (creatinine); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09754991 chr13:107220236 ARGLU1 -0.48 -6.67 -0.38 1.45e-10 Gut microbiota (bacterial taxa); CESC cis rs9300255 0.739 rs4759371 chr12:123742563 T/C cg05973401 chr12:123451056 ABCB9 0.49 5.52 0.32 8.03e-8 Neutrophil percentage of white cells; CESC trans rs55872338 0.588 rs7923238 chr10:44539457 T/C cg04664161 chr19:1876758 NA 0.63 6.13 0.35 3.16e-9 Facial morphology (factor 20); CESC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg08888203 chr3:10149979 C3orf24 0.49 6.14 0.35 2.98e-9 Alzheimer's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11278799 chr20:13765577 ESF1;C20orf7 -0.5 -6.14 -0.35 2.97e-9 Ulcerative colitis; CESC cis rs2479724 0.846 rs2488338 chr6:41808351 A/G cg08135965 chr6:41755394 TOMM6 0.41 5.49 0.32 9.26e-8 Menarche (age at onset); CESC cis rs7208859 0.673 rs73265612 chr17:29225983 A/G cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.54 0.42 7.51e-13 Bipolar disorder; CESC cis rs870825 0.616 rs35818632 chr4:185649661 G/T cg04058563 chr4:185651563 MLF1IP 0.64 6.51 0.37 3.78e-10 Blood protein levels; CESC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg18190219 chr22:46762943 CELSR1 -0.59 -6.57 -0.37 2.66e-10 LDL cholesterol;Cholesterol, total; CESC cis rs858239 0.539 rs6965833 chr7:23192366 T/C cg23682824 chr7:23144976 KLHL7 0.5 6.78 0.38 7.91e-11 Cerebrospinal fluid biomarker levels; CESC cis rs721399 0.553 rs10095072 chr8:18244662 G/T cg18736775 chr8:18248649 NAT2 -0.47 -5.36 -0.31 1.83e-7 Blood metabolite levels; CESC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg00290607 chr11:67383545 NA 0.46 6.71 0.38 1.2e-10 Mean corpuscular volume; CESC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg18230493 chr5:56204884 C5orf35 -0.79 -9.6 -0.51 6.61e-19 Initial pursuit acceleration; CESC cis rs6032067 0.777 rs13037087 chr20:43834313 T/C cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.56e-7 Blood protein levels; CESC cis rs9611565 0.625 rs12483991 chr22:41935285 A/G cg06634786 chr22:41940651 POLR3H -0.48 -5.25 -0.31 3.1e-7 Vitiligo; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13576061 chr5:55291172 IL6ST -0.49 -6.8 -0.39 7.12e-11 Gut microbiota (bacterial taxa); CESC trans rs17685 0.753 rs6951808 chr7:75772413 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 12.42 0.61 3.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.82 -10.58 -0.54 4.86e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1707322 0.721 rs10430123 chr1:46221440 T/C cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs77216612 0.877 rs7956514 chr12:12879254 T/G cg24098013 chr12:12878779 APOLD1 0.56 6.87 0.39 4.46e-11 Lymphocyte counts; CESC cis rs722599 0.715 rs61978928 chr14:75321714 T/C cg08847533 chr14:75593920 NEK9 -0.48 -5.94 -0.34 8.71e-9 IgG glycosylation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11851257 chr17:47903406 MYST2 0.4 6.09 0.35 3.97e-9 Gambling; CESC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg17376030 chr22:41985996 PMM1 -0.71 -7.49 -0.42 1.06e-12 Crohn's disease;Inflammatory bowel disease; CESC trans rs1728785 0.901 rs8050289 chr16:68566976 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs3820068 0.581 rs72645874 chr1:15926238 C/G cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg27125505 chr17:43679177 LOC644172 0.51 6.6 0.38 2.29e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9291683 0.620 rs717615 chr4:10104670 C/T cg00071950 chr4:10020882 SLC2A9 0.59 9.39 0.5 2.9e-18 Bone mineral density; CESC cis rs6582630 0.531 rs3850000 chr12:38483752 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.11 0.35 3.63e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs3008870 0.536 rs2208576 chr1:67513401 C/G cg02640540 chr1:67518911 SLC35D1 -0.64 -8.57 -0.47 8.4e-16 Lymphocyte percentage of white cells; CESC trans rs1814175 0.645 rs1874969 chr11:49826700 G/A cg03929089 chr4:120376271 NA -0.86 -13.73 -0.64 8.88e-33 Height; CESC cis rs1348850 0.918 rs4893966 chr2:178470138 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.67 0.43 3.36e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg16405210 chr4:1374714 KIAA1530 0.45 5.58 0.32 5.89e-8 Obesity-related traits; CESC cis rs478304 0.593 rs7120713 chr11:65483374 G/C cg10518572 chr11:65560635 OVOL1 -0.26 -5.05 -0.3 8.26e-7 Acne (severe); CESC cis rs12681366 0.734 rs10102233 chr8:95401657 A/T cg13257157 chr8:95487014 RAD54B 0.38 5.14 0.3 5.22e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs9549367 0.773 rs9549717 chr13:113908826 A/G cg00898013 chr13:113819073 PROZ -0.52 -7.46 -0.42 1.2e-12 Platelet distribution width; CESC cis rs4720575 1.000 rs1074575 chr7:47090545 A/C cg00036614 chr7:47093842 NA -0.43 -6.63 -0.38 1.82e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs2439831 0.850 rs7174208 chr15:44052682 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.75 0.38 9.27e-11 Lung cancer in ever smokers; CESC cis rs524281 0.647 rs2302883 chr11:65824994 T/C cg14036092 chr11:66035641 RAB1B -0.58 -6.33 -0.36 1.02e-9 Electroencephalogram traits; CESC cis rs7481584 0.624 rs428726 chr11:3046201 G/A cg25174290 chr11:3078921 CARS -0.48 -6.65 -0.38 1.68e-10 Calcium levels; CESC cis rs870825 0.616 rs28649620 chr4:185648997 G/A cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs6061231 1.000 rs11696991 chr20:60959694 G/T cg06197360 chr20:60970103 CABLES2 -0.41 -5.31 -0.31 2.27e-7 Colorectal cancer; CESC cis rs9905704 0.914 rs2643117 chr17:56829516 G/A cg12560992 chr17:57184187 TRIM37 0.62 7.1 0.4 1.11e-11 Testicular germ cell tumor; CESC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg24818145 chr4:99064322 C4orf37 0.44 5.55 0.32 6.81e-8 Colonoscopy-negative controls vs population controls; CESC cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg03060546 chr3:49711283 APEH 0.49 6.03 0.35 5.41e-9 Parkinson's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19143282 chr18:77507733 CTDP1 0.48 6.72 0.38 1.13e-10 Fibrinogen levels; CESC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg16262614 chr3:133464971 TF 0.31 5.47 0.32 1.02e-7 Iron status biomarkers; CESC cis rs2361718 0.564 rs2304844 chr17:78084507 G/C cg14949292 chr17:78079608 GAA -0.35 -5.14 -0.3 5.29e-7 Yeast infection; CESC cis rs7511006 0.893 rs2038049 chr22:50654888 G/C cg16473166 chr22:50639996 SELO 0.59 8.12 0.45 1.72e-14 Obesity-related traits; CESC cis rs2933343 1.000 rs1680790 chr3:128625853 G/T cg25356066 chr3:128598488 ACAD9 0.61 7.44 0.42 1.37e-12 IgG glycosylation; CESC cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg22467129 chr15:76604101 ETFA -0.38 -5.81 -0.34 1.81e-8 Blood metabolite levels; CESC cis rs7959452 0.640 rs11177599 chr12:69721970 G/A cg22834771 chr12:69754056 YEATS4 -0.39 -5.1 -0.3 6.57e-7 Blood protein levels; CESC cis rs7560272 0.502 rs4513320 chr2:73920741 T/C cg20560298 chr2:73613845 ALMS1 0.45 6.13 0.35 3.12e-9 Schizophrenia; CESC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.35 -0.31 1.89e-7 Total body bone mineral density; CESC cis rs2354432 0.556 rs885305 chr1:146786080 G/A cg25205988 chr1:146714368 CHD1L -1.04 -8.87 -0.48 1.13e-16 Mitochondrial DNA levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19558860 chr14:93582779 ITPK1 0.59 7.15 0.4 8.59e-12 Gut microbiome composition (summer); CESC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg02038168 chr22:39784481 NA 0.54 7.0 0.4 2.07e-11 IgG glycosylation; CESC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg00684032 chr4:1343700 KIAA1530 0.4 5.46 0.32 1.1e-7 Obesity-related traits; CESC cis rs4253772 0.550 rs9615953 chr22:46731024 C/G cg00784671 chr22:46762841 CELSR1 -0.62 -6.0 -0.35 6.33e-9 LDL cholesterol;Cholesterol, total; CESC cis rs6952809 0.532 rs6956223 chr7:2431331 T/C cg23289794 chr7:2394357 EIF3B -0.85 -7.73 -0.43 2.24e-13 Multiple sclerosis; CESC cis rs7727544 0.684 rs274561 chr5:131719228 A/C cg07395648 chr5:131743802 NA -0.4 -5.22 -0.31 3.62e-7 Blood metabolite levels; CESC cis rs11098499 0.954 rs59394118 chr4:120295551 A/G cg09307838 chr4:120376055 NA 0.94 12.84 0.62 1.16e-29 Corneal astigmatism; CESC cis rs708547 0.647 rs1713982 chr4:57881715 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -5.58 -0.32 6.06e-8 Response to bleomycin (chromatid breaks); CESC cis rs9527 0.590 rs943039 chr10:104825132 C/T cg04362960 chr10:104952993 NT5C2 0.45 5.76 0.33 2.34e-8 Arsenic metabolism; CESC cis rs1801251 1.000 rs1044480 chr2:233633736 A/G cg25237894 chr2:233734115 C2orf82 0.44 7.63 0.42 4.32e-13 Coronary artery disease; CESC cis rs9457247 0.663 rs2282860 chr6:167440244 T/C cg23791538 chr6:167370224 RNASET2 -0.57 -7.7 -0.43 2.7e-13 Crohn's disease; CESC cis rs523522 0.962 rs603574 chr12:120998443 A/G cg27279351 chr12:120934652 DYNLL1 0.68 8.84 0.48 1.4e-16 High light scatter reticulocyte count; CESC cis rs698833 0.886 rs2241871 chr2:44548613 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.59 7.25 0.41 4.68e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs6460942 1.000 rs6460935 chr7:12401317 A/T cg06484146 chr7:12443880 VWDE -0.7 -8.06 -0.44 2.57e-14 Coronary artery disease; CESC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.69 -10.85 -0.55 6.13e-23 Personality dimensions; CESC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg11644478 chr21:40555479 PSMG1 -0.8 -12.02 -0.59 7.35e-27 Cognitive function; CESC cis rs2370759 1.000 rs11597888 chr10:32635834 G/A cg18270830 chr10:32634957 EPC1 0.71 6.87 0.39 4.58e-11 Sexual dysfunction (female); CESC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg06108461 chr20:60628389 TAF4 0.52 6.16 0.35 2.63e-9 Obesity-related traits; CESC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.38 -6.14 -0.35 2.97e-9 Cystic fibrosis severity; CESC cis rs6499255 0.951 rs16959025 chr16:69695589 G/T cg15192750 chr16:69999425 NA -0.47 -5.09 -0.3 6.69e-7 IgE levels; CESC cis rs72949976 0.864 rs62186566 chr2:214024421 G/A cg08319019 chr2:214017104 IKZF2 -0.46 -5.71 -0.33 3.08e-8 Lung cancer;Squamous cell lung carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00437443 chr6:11094621 LOC221710 -0.58 -6.35 -0.36 9.33e-10 Gut microbiome composition (summer); CESC cis rs12497850 1.000 rs4858831 chr3:48735558 C/T cg06212747 chr3:49208901 KLHDC8B 0.6 8.1 0.45 2.05e-14 Parkinson's disease; CESC cis rs4654899 1.000 rs10799685 chr1:21465930 A/C cg05370193 chr1:21551575 ECE1 -0.38 -5.75 -0.33 2.4e-8 Superior frontal gyrus grey matter volume; CESC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs5758659 0.652 rs4822084 chr22:42435868 A/G cg19513890 chr22:42538836 CYP2D7P1 0.37 5.26 0.31 2.92e-7 Cognitive function; CESC cis rs561341 1.000 rs560132 chr17:30320019 C/T cg23018236 chr17:30244563 NA -0.55 -5.29 -0.31 2.57e-7 Hip circumference adjusted for BMI; CESC cis rs7654585 0.645 rs6828416 chr4:25933273 C/T cg10409131 chr4:25915609 C4orf52 0.7 9.52 0.5 1.1e-18 Obesity-related traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06745235 chr1:180471494 ACBD6 -0.42 -6.17 -0.35 2.49e-9 Gambling; CESC cis rs9796 0.621 rs2918462 chr15:41481254 A/G cg18705301 chr15:41695430 NDUFAF1 0.44 6.51 0.37 3.8e-10 Menopause (age at onset); CESC cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg12386194 chr3:101231763 SENP7 -0.43 -5.57 -0.32 6.16e-8 Colorectal cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08330572 chr5:620259 CEP72 0.47 6.16 0.35 2.65e-9 Fibrinogen levels; CESC cis rs2262909 0.962 rs56369285 chr19:22267185 T/C cg11619707 chr19:22235551 ZNF257 0.34 5.44 0.32 1.24e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs9300255 0.596 rs10734901 chr12:123743447 G/A cg05973401 chr12:123451056 ABCB9 0.44 5.46 0.32 1.12e-7 Neutrophil percentage of white cells; CESC cis rs116095464 0.558 rs59284383 chr5:284525 C/G cg10591111 chr5:226296 SDHA -0.53 -6.43 -0.37 6.03e-10 Breast cancer; CESC cis rs589448 0.867 rs623853 chr12:69753830 G/A cg14784868 chr12:69753453 YEATS4 0.92 14.57 0.67 1.05e-35 Cerebrospinal fluid biomarker levels; CESC trans rs61931739 0.534 rs11052960 chr12:33997754 A/T cg26384229 chr12:38710491 ALG10B 0.58 8.14 0.45 1.51e-14 Morning vs. evening chronotype; CESC cis rs9287719 0.901 rs10210859 chr2:10733929 C/T cg02196655 chr2:10830764 NOL10 -0.36 -5.57 -0.32 6.1e-8 Prostate cancer; CESC cis rs34638657 0.732 rs62045962 chr16:82200604 T/C cg09439754 chr16:82129088 HSD17B2 -0.36 -6.24 -0.36 1.71e-9 Lung adenocarcinoma; CESC cis rs7851660 0.775 rs7034336 chr9:100661100 C/T cg13688889 chr9:100608707 NA -0.62 -8.87 -0.48 1.11e-16 Strep throat; CESC cis rs12220238 1.000 rs10824076 chr10:75886956 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.66 6.68 0.38 1.42e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2242194 0.816 rs6671688 chr1:154994265 T/C cg12436631 chr1:155007014 DCST1;DCST2 0.47 8.26 0.45 6.78e-15 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13762257 chr11:45864900 NA -0.56 -6.79 -0.38 7.38e-11 Gut microbiome composition (summer); CESC cis rs1055129 0.560 rs56248937 chr17:73915153 T/A cg08125733 chr17:73851984 WBP2 0.52 7.12 0.4 1.02e-11 White matter hyperintensity burden; CESC cis rs910316 0.663 rs175034 chr14:75463687 T/G cg16144293 chr14:75469539 EIF2B2 0.41 5.45 0.32 1.18e-7 Height; CESC cis rs6582630 0.533 rs11181379 chr12:38332381 C/T cg26384229 chr12:38710491 ALG10B 0.43 5.97 0.34 7.51e-9 Drug-induced liver injury (flucloxacillin); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09026224 chr5:172484103 C5orf41 -0.43 -6.06 -0.35 4.59e-9 Gambling; CESC cis rs870825 0.616 rs28450662 chr4:185638900 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC cis rs9788682 1.000 rs2036534 chr15:78826948 T/C cg24631222 chr15:78858424 CHRNA5 0.77 9.97 0.52 4.29e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs2288073 0.965 rs36101491 chr2:24387532 C/T cg06627628 chr2:24431161 ITSN2 -0.86 -9.78 -0.52 1.73e-19 Venous thromboembolism (SNP x SNP interaction); CESC cis rs4319547 1.000 rs6489156 chr12:123100397 C/T cg23029597 chr12:123009494 RSRC2 -0.45 -5.12 -0.3 6.02e-7 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00222982 chr11:125439225 EI24 0.57 6.8 0.39 6.78e-11 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14551182 chr11:16626476 NA -0.42 -6.58 -0.37 2.44e-10 Gambling; CESC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg24829409 chr8:58192753 C8orf71 -0.66 -7.57 -0.42 6.15e-13 Developmental language disorder (linguistic errors); CESC cis rs9430161 0.611 rs35033941 chr1:11034382 C/T cg02454025 chr1:11042201 C1orf127 0.99 16.1 0.7 3.84e-41 Ewing sarcoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04246357 chr6:158589294 SERAC1;GTF2H5 0.56 6.35 0.36 9.07e-10 Gut microbiome composition (summer); CESC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg02221750 chr19:17393354 ANKLE1 -0.5 -6.0 -0.35 6.62e-9 Systemic lupus erythematosus; CESC cis rs4835473 0.868 rs5025156 chr4:144659178 T/A cg25736465 chr4:144833511 NA -0.43 -6.57 -0.37 2.72e-10 Immature fraction of reticulocytes; CESC cis rs7940866 0.774 rs10466547 chr11:130823576 T/C cg12179176 chr11:130786555 SNX19 0.68 10.05 0.53 2.44e-20 Schizophrenia; CESC cis rs7927592 0.763 rs624003 chr11:68231240 C/T cg20283391 chr11:68216788 NA -0.46 -5.63 -0.33 4.67e-8 Total body bone mineral density; CESC cis rs1348850 0.632 rs1358328 chr2:178517532 G/A cg22681709 chr2:178499509 PDE11A -0.58 -8.82 -0.48 1.58e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7078219 0.505 rs6584282 chr10:101286495 A/G cg09788492 chr10:101292477 NKX2-3 0.33 6.25 0.36 1.62e-9 Dental caries; CESC cis rs2880765 0.835 rs6496027 chr15:86049988 C/T cg19183879 chr15:85880815 NA -0.25 -5.12 -0.3 5.89e-7 Coronary artery disease; CESC cis rs6963495 0.818 rs56251768 chr7:105165591 A/G cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC trans rs801193 1.000 rs10252765 chr7:66228732 C/G cg26939375 chr7:64535504 NA 0.62 7.87 0.44 9.34e-14 Aortic root size; CESC cis rs763121 0.853 rs9610986 chr22:39025277 T/C cg21395723 chr22:39101663 GTPBP1 0.43 5.29 0.31 2.58e-7 Menopause (age at onset); CESC cis rs3008870 0.755 rs2815364 chr1:67498384 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 7.97 0.44 4.75e-14 Lymphocyte percentage of white cells; CESC cis rs4986811 1.000 rs11031780 chr11:32452945 C/G cg27409910 chr11:32454216 WT1 0.49 6.29 0.36 1.3e-9 Rubella-specific interleukin-6 secretion; CESC cis rs11264213 0.901 rs79303353 chr1:36402056 G/A cg27506609 chr1:36549197 TEKT2 0.66 5.55 0.32 6.79e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02759888 chr15:63449753 RPS27L 0.64 7.66 0.43 3.49e-13 Gut microbiome composition (summer); CESC cis rs7635838 0.964 rs7624086 chr3:11412620 C/G cg00170343 chr3:11313890 ATG7 0.39 5.12 0.3 5.85e-7 HDL cholesterol; CESC cis rs2742234 0.541 rs10899778 chr10:43718509 G/C cg15436174 chr10:43711423 RASGEF1A 0.47 5.58 0.32 5.81e-8 Hirschsprung disease; CESC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg04518342 chr5:131593106 PDLIM4 0.41 6.16 0.35 2.72e-9 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06538771 chr22:50636937 TRABD -0.51 -6.04 -0.35 5.08e-9 Gut microbiome composition (summer); CESC cis rs1005277 0.505 rs200936 chr10:38134935 T/C cg00409905 chr10:38381863 ZNF37A -0.55 -7.6 -0.42 5.03e-13 Extrinsic epigenetic age acceleration; CESC cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs7772486 0.738 rs9485039 chr6:146319387 C/T cg05347473 chr6:146136440 FBXO30 0.5 6.53 0.37 3.39e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4889855 0.530 rs7220588 chr17:78598231 G/A cg16591659 chr17:78472290 NA -0.33 -5.25 -0.31 3.08e-7 Fractional excretion of uric acid; CESC cis rs854765 0.693 rs4924823 chr17:17764502 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.45 -5.86 -0.34 1.4e-8 Total body bone mineral density; CESC cis rs2710642 0.586 rs12713462 chr2:62804482 C/T cg17519650 chr2:63277830 OTX1 0.45 6.02 0.35 5.82e-9 LDL cholesterol levels;LDL cholesterol; CESC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.02e-11 Tonsillectomy; CESC cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg24879335 chr3:133465180 TF 0.47 9.17 0.49 1.4e-17 Iron status biomarkers (transferrin levels); CESC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg10074409 chr1:209979377 IRF6 0.4 5.22 0.31 3.59e-7 Cleft lip with or without cleft palate; CESC cis rs6500395 0.926 rs8057777 chr16:48565643 T/C cg04672837 chr16:48644449 N4BP1 0.44 5.26 0.31 2.96e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg02353165 chr6:42928485 GNMT 0.85 14.82 0.67 1.36e-36 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4481887 1.000 rs6659039 chr1:248465689 C/T cg00666640 chr1:248458726 OR2T12 0.39 6.31 0.36 1.19e-9 Common traits (Other); CESC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg26335602 chr6:28129616 ZNF389 0.54 7.3 0.41 3.37e-12 Depression; CESC cis rs9788682 0.747 rs11637630 chr15:78899719 G/A cg24631222 chr15:78858424 CHRNA5 -0.82 -10.19 -0.53 8.81e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -5.99 -0.35 6.73e-9 Parkinson's disease; CESC cis rs4523957 0.820 rs216193 chr17:2203453 A/G cg16513277 chr17:2031491 SMG6 0.54 7.08 0.4 1.28e-11 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6933660 0.760 rs6904364 chr6:151754273 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.6 8.04 0.44 3.09e-14 Menarche (age at onset); CESC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg04025307 chr7:1156635 C7orf50 0.44 5.33 0.31 2.16e-7 Bronchopulmonary dysplasia; CESC cis rs35110281 0.837 rs2838341 chr21:45076443 A/G cg04455712 chr21:45112962 RRP1B 0.4 5.99 0.35 6.65e-9 Mean corpuscular volume; CESC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.23 0.53 6.6e-21 Prudent dietary pattern; CESC cis rs1538970 0.816 rs11211124 chr1:45962409 T/C cg06784218 chr1:46089804 CCDC17 0.37 5.9 0.34 1.11e-8 Platelet count; CESC cis rs939658 0.805 rs11634679 chr15:79432475 T/C cg17916960 chr15:79447300 NA -0.39 -6.34 -0.36 1.01e-9 Refractive error; CESC cis rs4891159 0.790 rs683306 chr18:74112473 C/G cg24786174 chr18:74118243 ZNF516 -0.76 -12.12 -0.6 3.38e-27 Longevity; CESC cis rs4604732 0.588 rs7549495 chr1:247627806 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 6.01 0.35 6.07e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs897984 0.683 rs72799316 chr16:30827205 A/G cg00531865 chr16:30841666 NA -0.57 -8.63 -0.47 5.61e-16 Dementia with Lewy bodies; CESC cis rs9457247 0.967 rs385460 chr6:167403888 A/T cg07741184 chr6:167504864 NA 0.28 5.1 0.3 6.54e-7 Crohn's disease; CESC cis rs523522 0.924 rs11065150 chr12:120958875 T/G cg12219531 chr12:120966889 COQ5 0.74 9.95 0.52 5.04e-20 High light scatter reticulocyte count; CESC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -5.95 -0.34 8.57e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg19748678 chr4:122722346 EXOSC9 0.79 10.06 0.53 2.23e-20 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18911472 chr17:56736863 TEX14 0.54 6.12 0.35 3.36e-9 Gut microbiome composition (summer); CESC cis rs2046867 0.818 rs67355490 chr3:72830935 T/C cg25664220 chr3:72788482 NA -0.46 -6.73 -0.38 1.06e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs826838 0.868 rs864324 chr12:39122853 A/G cg26384229 chr12:38710491 ALG10B 0.61 9.8 0.52 1.48e-19 Heart rate; CESC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.44 -5.76 -0.33 2.36e-8 Tonsillectomy; CESC cis rs7264396 0.747 rs2425151 chr20:34394541 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -11.37 -0.57 1.2e-24 Total cholesterol levels; CESC cis rs728616 0.614 rs59806247 chr10:82097974 T/C cg05935833 chr10:81318306 SFTPA2 -0.37 -5.37 -0.31 1.76e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs11997175 0.603 rs4739382 chr8:33807012 C/T ch.8.33884649F chr8:33765107 NA 0.5 5.99 0.35 6.87e-9 Body mass index; CESC cis rs3815700 1.000 rs8104328 chr19:33094371 G/A cg24916020 chr19:33096688 ANKRD27 0.59 5.8 0.34 1.92e-8 Eosinophilic esophagitis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04792727 chr1:231664260 TSNAX-DISC1;TSNAX -0.45 -6.21 -0.36 2.05e-9 Asthma; CESC cis rs1538970 1.000 rs11211101 chr1:45849311 C/G cg05343316 chr1:45956843 TESK2 0.8 11.45 0.58 6.43e-25 Platelet count; CESC cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg23711669 chr6:146136114 FBXO30 0.97 14.47 0.66 2.25e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs7264396 0.528 rs6058370 chr20:34518592 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -9.27 -0.49 6.63e-18 Total cholesterol levels; CESC cis rs10911251 0.508 rs10797854 chr1:183106739 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 12.94 0.62 5.33e-30 Colorectal cancer; CESC cis rs9811920 0.809 rs793464 chr3:99626028 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.47 7.83 0.43 1.2e-13 Axial length; CESC cis rs34779708 0.766 rs35308730 chr10:35549796 C/T cg04310649 chr10:35416472 CREM -0.46 -5.22 -0.31 3.55e-7 Inflammatory bowel disease;Crohn's disease; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg22174355 chr9:114413582 DNAJC25;DNAJC25-GNG10 0.46 7.52 0.42 8.68e-13 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9787249 0.957 rs10888958 chr1:40211737 T/C cg02773041 chr1:40204384 PPIE 0.54 7.68 0.43 3.02e-13 Blood protein levels; CESC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg18876405 chr7:65276391 NA -0.56 -7.74 -0.43 2.15e-13 Aortic root size; CESC cis rs4803468 1.000 rs284657 chr19:41929915 G/C cg09537434 chr19:41945824 ATP5SL -1.04 -18.8 -0.76 1.09e-50 Height; CESC cis rs864537 0.676 rs2988279 chr1:167419839 G/A cg22356347 chr1:167427500 CD247 -0.37 -7.68 -0.43 3.06e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs6089829 0.925 rs4809270 chr20:61676709 C/A cg03213289 chr20:61660250 NA 0.35 5.23 0.31 3.49e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs7980799 0.716 rs10161311 chr12:33623204 G/A cg26384229 chr12:38710491 ALG10B -0.58 -8.26 -0.45 7.19e-15 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Depression; CESC cis rs9549367 0.789 rs7338235 chr13:113888687 T/C cg00898013 chr13:113819073 PROZ -0.51 -6.85 -0.39 5.17e-11 Platelet distribution width; CESC cis rs9583531 0.600 rs754599 chr13:111354788 C/A cg24331049 chr13:111365604 ING1 0.71 10.37 0.54 2.35e-21 Coronary artery disease; CESC cis rs7665939 0.932 rs10022377 chr4:190108803 C/T cg14840187 chr4:190284988 NA -0.54 -5.68 -0.33 3.54e-8 Amyotrophic lateral sclerosis; CESC cis rs6690583 0.562 rs6665436 chr1:85532894 T/C cg22153463 chr1:85462885 MCOLN2 0.74 7.15 0.4 8.67e-12 Serum sulfate level; CESC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg22508957 chr16:3507546 NAT15 0.72 9.08 0.49 2.51e-17 Tuberculosis; CESC cis rs4561483 0.801 rs33620 chr16:12008546 C/G cg08843971 chr16:11963173 GSPT1 -0.55 -8.19 -0.45 1.12e-14 Testicular germ cell tumor; CESC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.21e-8 Developmental language disorder (linguistic errors); CESC trans rs459571 0.916 rs467303 chr9:136904835 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.6 -7.69 -0.43 2.96e-13 Platelet distribution width; CESC cis rs10129255 0.518 rs11847766 chr14:107187425 T/C cg23076370 chr14:107095027 NA -0.66 -10.03 -0.52 2.9e-20 Kawasaki disease; CESC cis rs11190604 0.945 rs2495746 chr10:102328270 T/C cg07080220 chr10:102295463 HIF1AN 0.55 5.37 0.31 1.76e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs710216 0.536 rs710222 chr1:43413653 A/G cg07803811 chr1:43423981 SLC2A1 0.62 8.42 0.46 2.43e-15 Red cell distribution width; CESC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs2522056 1.000 rs2405528 chr5:131794298 G/A cg24060327 chr5:131705240 SLC22A5 0.62 7.18 0.4 6.85e-12 Lymphocyte counts;Fibrinogen; CESC cis rs4237845 0.537 rs1599931 chr12:58258850 A/G cg00677455 chr12:58241039 CTDSP2 0.78 10.5 0.54 8.36e-22 Intelligence (multi-trait analysis); CESC cis rs7927771 0.524 rs7936948 chr11:47704200 T/G cg18512352 chr11:47633146 NA 0.35 5.39 0.31 1.53e-7 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12163800 chr17:74475355 RHBDF2 -0.53 -6.64 -0.38 1.74e-10 Gut microbiome composition (summer); CESC cis rs631288 0.793 rs10793659 chr1:146763438 A/G cg25205988 chr1:146714368 CHD1L 1.14 7.58 0.42 5.91e-13 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs7927592 0.913 rs12272917 chr11:68263370 T/C cg20283391 chr11:68216788 NA -0.62 -7.54 -0.42 7.45e-13 Total body bone mineral density; CESC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg12463550 chr7:65579703 CRCP -0.55 -7.09 -0.4 1.19e-11 Aortic root size; CESC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg13114125 chr14:105738426 BRF1 -0.79 -9.77 -0.51 1.91e-19 Mean platelet volume;Platelet distribution width; CESC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg03188948 chr7:1209495 NA 0.57 6.61 0.38 2.07e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6690583 0.623 rs893618 chr1:85513770 C/T cg22488158 chr1:85528044 WDR63 0.56 5.74 0.33 2.6e-8 Serum sulfate level; CESC cis rs11168351 0.833 rs6580652 chr12:48447105 C/A cg24011408 chr12:48396354 COL2A1 -0.49 -7.41 -0.41 1.74e-12 Bipolar disorder and schizophrenia; CESC cis rs4666360 1.000 rs4666359 chr2:20335614 G/A cg23291376 chr2:20336282 NA -0.37 -6.11 -0.35 3.48e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel); CESC cis rs9611565 0.614 rs4822053 chr22:42212936 C/A cg03806693 chr22:41940476 POLR3H -0.69 -8.23 -0.45 8.34e-15 Vitiligo; CESC cis rs9549367 0.789 rs35569628 chr13:113872712 T/C cg18105134 chr13:113819100 PROZ -0.69 -9.08 -0.49 2.62e-17 Platelet distribution width; CESC cis rs926938 0.584 rs360606 chr1:115391769 C/T cg12756093 chr1:115239321 AMPD1 0.46 6.28 0.36 1.38e-9 Autism; CESC cis rs2243480 1.000 rs160637 chr7:65584318 C/T cg13147721 chr7:65941812 NA -0.99 -9.36 -0.5 3.5e-18 Diabetic kidney disease; CESC cis rs2012796 1.000 rs12436146 chr14:81821282 A/G cg02996355 chr14:81879375 NA 0.51 5.94 0.34 9.08e-9 Night sleep phenotypes; CESC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg04756594 chr16:24857601 SLC5A11 0.51 6.04 0.35 5.3300000000000004e-09 Intelligence (multi-trait analysis); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03260790 chr12:56211718 ORMDL2;SARNP -0.5 -6.48 -0.37 4.5e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg09658497 chr7:2847517 GNA12 -0.43 -6.15 -0.35 2.86e-9 Height; CESC cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg23711669 chr6:146136114 FBXO30 0.98 15.12 0.68 1.11e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg17366294 chr4:99064904 C4orf37 0.57 7.93 0.44 6.29e-14 Colonoscopy-negative controls vs population controls; CESC cis rs6693567 0.545 rs2133129 chr1:150355537 T/C cg09579323 chr1:150459698 TARS2 0.47 5.91 0.34 1.04e-8 Migraine; CESC cis rs36051895 0.622 rs12335546 chr9:5072182 C/T cg02405213 chr9:5042618 JAK2 -0.48 -5.91 -0.34 1.06e-8 Pediatric autoimmune diseases; CESC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg00802000 chr16:706648 WDR90 -0.4 -6.17 -0.35 2.52e-9 Height; CESC cis rs9389248 0.690 rs6939543 chr6:135255143 A/G cg22676075 chr6:135203613 NA -0.6 -8.55 -0.46 1.03e-15 High light scatter reticulocyte percentage of red cells; CESC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs72901758 0.768 rs11657271 chr17:76249682 A/T cg25512537 chr17:76250053 NA 0.38 5.28 0.31 2.74e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs2952156 1.000 rs2643194 chr17:37853048 C/T cg07936489 chr17:37558343 FBXL20 -0.5 -5.91 -0.34 1.04e-8 Asthma; CESC cis rs2997447 0.655 rs11247852 chr1:26383125 C/G cg19633962 chr1:26362018 EXTL1 0.58 6.14 0.35 2.95e-9 QRS complex (12-leadsum); CESC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg18446336 chr7:2847575 GNA12 -0.34 -5.39 -0.31 1.52e-7 Height; CESC cis rs7833986 0.501 rs2719258 chr8:56941389 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.4 0.41 1.78e-12 Height; CESC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg00409905 chr10:38381863 ZNF37A -0.46 -6.13 -0.35 3.17e-9 Extrinsic epigenetic age acceleration; CESC cis rs11098499 0.697 rs35280960 chr4:120257059 G/A cg09307838 chr4:120376055 NA 0.79 10.45 0.54 1.29e-21 Corneal astigmatism; CESC cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg21918786 chr6:109611834 NA -0.39 -6.04 -0.35 5.08e-9 Reticulocyte fraction of red cells; CESC cis rs3733585 0.637 rs6850684 chr4:9964380 G/T cg11266682 chr4:10021025 SLC2A9 -0.6 -11.15 -0.57 6.33e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2439831 0.867 rs2255440 chr15:43830467 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 8.28 0.45 6.19e-15 Lung cancer in ever smokers; CESC cis rs6752107 0.967 rs6431661 chr2:234167421 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.46 6.33 0.36 1.03e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs9467711 0.606 rs9379859 chr6:26369549 C/T cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2180341 0.961 rs9375501 chr6:127652539 C/T cg24812749 chr6:127587940 RNF146 1.07 15.4 0.69 1.16e-38 Breast cancer; CESC cis rs372883 0.648 rs11088117 chr21:30737816 G/C cg08807101 chr21:30365312 RNF160 0.43 5.04 0.3 8.76e-7 Pancreatic cancer; CESC cis rs2243480 1.000 rs73142121 chr7:65311206 C/T cg25894440 chr7:65020034 NA -0.6 -5.32 -0.31 2.19e-7 Diabetic kidney disease; CESC cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg25517755 chr10:38738941 LOC399744 -0.47 -6.04 -0.35 5.12e-9 Extrinsic epigenetic age acceleration; CESC cis rs8092503 0.953 rs11152005 chr18:52480578 G/A cg12377874 chr18:52495404 RAB27B 0.38 6.2 0.36 2.13e-9 Childhood body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25722142 chr6:139695762 CITED2 -0.44 -6.39 -0.37 7.33e-10 Gambling; CESC cis rs12451471 0.500 rs8077056 chr17:78076006 C/T cg24585782 chr17:78113791 EIF4A3 -0.56 -7.07 -0.4 1.42e-11 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs2836950 0.501 rs2070865 chr21:40715519 C/T cg11644478 chr21:40555479 PSMG1 -0.49 -6.29 -0.36 1.29e-9 Menarche (age at onset); CESC cis rs3008870 0.755 rs2755242 chr1:67479598 T/C cg02640540 chr1:67518911 SLC35D1 0.45 5.43 0.32 1.25e-7 Lymphocyte percentage of white cells; CESC cis rs7429990 0.965 rs4599334 chr3:48066400 A/C cg11946769 chr3:48343235 NME6 -0.5 -6.0 -0.35 6.52e-9 Educational attainment (years of education); CESC cis rs5753037 0.543 rs131287 chr22:30158463 C/T cg01021169 chr22:30184971 ASCC2 -0.55 -7.84 -0.43 1.13e-13 Type 1 diabetes; CESC cis rs863345 0.625 rs10908663 chr1:158492121 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.24 0.36 1.69e-9 Menopause (age at onset); CESC cis rs9522267 0.535 rs11069897 chr13:112231319 A/G cg10483660 chr13:112241077 NA -0.33 -5.83 -0.34 1.65e-8 Hepatitis; CESC cis rs71277158 0.565 rs16854778 chr3:169748111 G/A cg04067573 chr3:169899625 PHC3 0.55 5.42 0.32 1.33e-7 Prostate cancer; CESC cis rs9309473 0.950 rs6711001 chr2:73850820 C/G cg20560298 chr2:73613845 ALMS1 -0.47 -6.19 -0.36 2.31e-9 Metabolite levels; CESC cis rs921968 0.643 rs2303561 chr2:219527005 C/T cg02176678 chr2:219576539 TTLL4 -0.42 -7.45 -0.42 1.33e-12 Mean corpuscular hemoglobin concentration; CESC cis rs3087591 0.960 rs2953000 chr17:29509791 C/T cg24425628 chr17:29625626 OMG;NF1 0.44 5.57 0.32 6.21e-8 Hip circumference; CESC cis rs3733585 0.673 rs9993410 chr4:9951264 C/T cg02734326 chr4:10020555 SLC2A9 -0.4 -5.66 -0.33 3.93e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7474896 0.559 rs1024202 chr10:38278977 A/C cg25427524 chr10:38739819 LOC399744 0.49 5.42 0.32 1.35e-7 Obesity (extreme); CESC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg16325326 chr1:53192061 ZYG11B -0.98 -17.59 -0.73 1.95e-46 Monocyte count; CESC cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg22467129 chr15:76604101 ETFA -0.38 -5.73 -0.33 2.69e-8 Blood metabolite levels; CESC cis rs7524258 0.900 rs12035586 chr1:7273020 C/T cg07173049 chr1:7289937 CAMTA1 -0.36 -5.6 -0.33 5.35e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs17253792 0.822 rs10149408 chr14:56046075 G/A cg01858014 chr14:56050164 KTN1 -0.94 -7.66 -0.43 3.47e-13 Putamen volume; CESC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg25405998 chr7:65216604 CCT6P1 0.45 5.06 0.3 7.71e-7 Aortic root size; CESC cis rs7726839 0.574 rs72705014 chr5:619815 C/G cg16447950 chr5:562315 NA -0.58 -5.93 -0.34 9.42e-9 Obesity-related traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14503796 chr3:15248442 DVWA;CAPN7 0.49 7.02 0.4 1.89e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg21724239 chr8:58056113 NA 0.6 5.33 0.31 2.12e-7 Developmental language disorder (linguistic errors); CESC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg11890956 chr21:40555474 PSMG1 -0.61 -8.58 -0.47 8.08e-16 Menarche (age at onset); CESC cis rs2522056 1.000 rs2522054 chr5:131799526 G/T cg07395648 chr5:131743802 NA 0.44 5.03 0.3 9.06e-7 Lymphocyte counts;Fibrinogen; CESC cis rs7274811 0.554 rs6120299 chr20:32133491 T/G cg21523528 chr20:32077966 CBFA2T2 0.63 7.25 0.41 4.68e-12 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10490227 chr1:40348903 TRIT1 0.52 6.14 0.35 2.98e-9 Gut microbiome composition (summer); CESC cis rs9039 1.000 rs9932208 chr16:9218267 T/C cg08831531 chr16:9218945 NA -0.44 -6.21 -0.36 2.05e-9 Menopause (age at onset); CESC cis rs4843185 0.576 rs380996 chr16:85728813 A/G cg05245094 chr16:85669572 KIAA0182 -0.39 -5.07 -0.3 7.34e-7 Platelet distribution width; CESC cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg22875332 chr1:76189707 ACADM -0.64 -6.77 -0.38 8.23e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1348850 0.519 rs10201883 chr2:178471407 T/C cg23306229 chr2:178417860 TTC30B 0.77 6.91 0.39 3.5e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg11766577 chr21:47581405 C21orf56 -0.47 -6.47 -0.37 4.84e-10 Testicular germ cell tumor; CESC cis rs3733585 0.673 rs4467564 chr4:9953472 G/T cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11718455 1.000 rs28731098 chr3:44019816 A/C cg08738300 chr3:44038990 NA 0.45 5.81 0.34 1.78e-8 Coronary artery disease; CESC cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg02574844 chr11:5959923 NA -0.44 -5.53 -0.32 7.81e-8 DNA methylation (variation); CESC cis rs4460629 0.742 rs6427158 chr1:155074903 G/T cg01019262 chr1:155095195 NA -0.3 -5.05 -0.3 8.42e-7 Serum magnesium levels; CESC cis rs807669 0.548 rs723414 chr22:19185736 G/A cg17887427 chr22:19166691 SLC25A1 -0.44 -5.29 -0.31 2.54e-7 Metabolite levels; CESC cis rs72781680 0.898 rs6545127 chr2:24060670 C/T cg08917208 chr2:24149416 ATAD2B 0.93 8.48 0.46 1.57e-15 Lymphocyte counts; CESC cis rs2439831 0.850 rs28858500 chr15:44156942 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.46 0.42 1.22e-12 Lung cancer in ever smokers; CESC cis rs1051424 0.651 rs1292063 chr17:57907768 T/A cg02344993 chr17:57696989 CLTC -0.68 -8.37 -0.46 3.31e-15 Obesity-related traits; CESC cis rs1348850 0.914 rs10170667 chr2:178336878 A/G cg23306229 chr2:178417860 TTC30B 0.65 7.98 0.44 4.46e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg24690094 chr11:67383802 NA -0.37 -6.2 -0.36 2.13e-9 Mean corpuscular volume; CESC cis rs929596 0.728 rs6744284 chr2:234625297 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.63 -8.15 -0.45 1.45e-14 Total bilirubin levels in HIV-1 infection; CESC cis rs941873 0.900 rs4979862 chr10:81131599 G/A cg08514558 chr10:81106712 PPIF 0.39 6.91 0.39 3.69e-11 Height; CESC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg07414643 chr4:187882934 NA 0.58 8.29 0.45 5.75e-15 Lobe attachment (rater-scored or self-reported); CESC cis rs9300255 0.698 rs4759416 chr12:123746357 C/G cg05973401 chr12:123451056 ABCB9 0.51 5.75 0.33 2.4e-8 Neutrophil percentage of white cells; CESC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -12.93 -0.62 5.44e-30 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00252332 chr13:73633178 KLF5 0.55 6.38 0.36 7.75e-10 Gut microbiome composition (summer); CESC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.79 13.26 0.63 3.89e-31 Personality dimensions; CESC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg07648498 chr16:89883185 FANCA 0.44 5.42 0.32 1.32e-7 Vitiligo; CESC cis rs539096 0.500 rs803678 chr1:44350898 G/T cg12908607 chr1:44402522 ARTN -0.49 -7.49 -0.42 1.04e-12 Intelligence (multi-trait analysis); CESC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.42 -0.37 6.22e-10 Life satisfaction; CESC cis rs1801251 1.000 rs13035829 chr2:233604487 A/T cg08000102 chr2:233561755 GIGYF2 0.64 9.1 0.49 2.29e-17 Coronary artery disease; CESC cis rs1707322 1.000 rs4660331 chr1:46458783 A/C cg05343316 chr1:45956843 TESK2 0.45 5.59 0.32 5.74e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6866344 0.570 rs1071882 chr5:178136040 C/T cg03877680 chr5:178157825 ZNF354A 0.8 10.15 0.53 1.12e-20 Neutrophil percentage of white cells; CESC cis rs1707322 0.716 rs28370457 chr1:46172062 C/T cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs61931739 0.500 rs7309931 chr12:34483471 A/C cg06521331 chr12:34319734 NA -0.37 -5.05 -0.3 8.21e-7 Morning vs. evening chronotype; CESC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg02772935 chr3:125709198 NA -0.46 -5.03 -0.3 8.9e-7 Blood pressure (smoking interaction); CESC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg09658497 chr7:2847517 GNA12 -0.44 -6.17 -0.35 2.59e-9 Height; CESC cis rs6665290 0.904 rs1045285 chr1:227179054 G/A cg10327440 chr1:227177885 CDC42BPA -1.21 -32.2 -0.89 1.35e-93 Myeloid white cell count; CESC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.16 -0.3 4.76e-7 Developmental language disorder (linguistic errors); CESC cis rs2273669 0.667 rs1407241 chr6:109328432 G/A cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg17178900 chr1:205818956 PM20D1 0.92 16.1 0.7 3.72e-41 Menarche (age at onset); CESC cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg23711669 chr6:146136114 FBXO30 1.01 15.9 0.7 2.05e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs2072732 0.808 rs67908307 chr1:2954297 T/C cg03976712 chr1:2946727 NA 0.33 5.53 0.32 7.83e-8 Plateletcrit; CESC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.15 -0.35 2.85e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7520050 0.902 rs4638056 chr1:46458153 T/G cg24296786 chr1:45957014 TESK2 0.45 5.65 0.33 4.17e-8 Red blood cell count;Reticulocyte count; CESC cis rs3806933 0.522 rs17553936 chr5:110454681 A/G cg04022379 chr5:110408740 TSLP 0.45 7.3 0.41 3.37e-12 Eosinophilic esophagitis; CESC cis rs3540 0.514 rs2601192 chr15:90936704 G/A cg10434728 chr15:90938212 IQGAP1 0.44 8.12 0.45 1.81e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg17971929 chr21:40555470 PSMG1 -0.86 -12.42 -0.61 3.16e-28 Cognitive function; CESC cis rs77106637 1.000 rs11605166 chr11:72669777 T/C cg03713592 chr11:72463424 ARAP1 1.14 10.42 0.54 1.59e-21 Type 2 diabetes; CESC cis rs7527798 0.592 rs12022909 chr1:207859743 T/C cg21110645 chr1:207815933 NA -0.33 -5.88 -0.34 1.26e-8 Erythrocyte sedimentation rate; CESC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs2072499 0.750 rs2241109 chr1:156173082 C/T cg25208724 chr1:156163844 SLC25A44 0.96 12.46 0.61 2.25e-28 Testicular germ cell tumor; CESC cis rs4727027 0.866 rs3927307 chr7:148774869 C/T cg23583168 chr7:148888333 NA -0.78 -11.69 -0.58 9.58e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9303401 0.614 rs34683543 chr17:56520036 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.95 11.87 0.59 2.32e-26 Cognitive test performance; CESC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg22823121 chr1:150693482 HORMAD1 0.47 6.96 0.39 2.6e-11 Tonsillectomy; CESC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg19592336 chr6:28129416 ZNF389 0.62 8.14 0.45 1.59e-14 Depression; CESC cis rs10838687 0.932 rs2596397 chr11:47247621 G/A cg25783544 chr11:47291846 MADD -0.57 -7.25 -0.41 4.71e-12 Proinsulin levels; CESC cis rs34375054 0.558 rs67041765 chr12:125672913 T/G cg05341575 chr12:125625032 AACS -0.38 -5.42 -0.32 1.33e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs72781680 1.000 rs72781648 chr2:24210333 T/C cg08917208 chr2:24149416 ATAD2B 0.92 8.28 0.45 6.31e-15 Lymphocyte counts; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18336435 chr15:60884637 RORA -0.46 -6.04 -0.35 5.31e-9 Ulcerative colitis; CESC cis rs523522 0.962 rs603574 chr12:120998443 A/G cg12219531 chr12:120966889 COQ5 0.75 9.89 0.52 7.64e-20 High light scatter reticulocyte count; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg18185028 chr3:154042079 DHX36 -0.42 -6.37 -0.36 8.43e-10 Breast cancer; CESC trans rs61931739 0.500 rs11053207 chr12:34459827 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.5 0.42 9.79e-13 Morning vs. evening chronotype; CESC cis rs3857536 0.785 rs1935895 chr6:66936606 T/G cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs3733585 0.605 rs7656624 chr4:10121097 T/C cg00071950 chr4:10020882 SLC2A9 -0.65 -10.42 -0.54 1.6e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs909002 0.800 rs1056526 chr1:32084904 C/T cg13919466 chr1:32135498 COL16A1 -0.45 -8.08 -0.44 2.28e-14 Intelligence (multi-trait analysis); CESC cis rs3087591 0.920 rs7225014 chr17:29572973 A/G cg24425628 chr17:29625626 OMG;NF1 -0.42 -5.23 -0.31 3.48e-7 Hip circumference; CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg16132339 chr22:24313637 DDTL;DDT -0.44 -6.85 -0.39 5.06e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg18758796 chr5:131593413 PDLIM4 -0.41 -5.66 -0.33 3.99e-8 Breast cancer; CESC cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 6.1e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg22535103 chr8:58192502 C8orf71 -0.89 -7.36 -0.41 2.3e-12 Developmental language disorder (linguistic errors); CESC cis rs10200850 1.000 rs4502439 chr2:240214762 G/A cg26975040 chr2:240205772 HDAC4 -0.58 -5.04 -0.3 8.44e-7 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs7809799 1.000 rs2395022 chr7:98750379 A/C cg05967295 chr7:98741636 SMURF1 -0.79 -5.65 -0.33 4.24e-8 Ulcerative colitis; CESC cis rs9457247 1.000 rs408080 chr6:167392522 T/C cg07741184 chr6:167504864 NA 0.3 5.51 0.32 8.58e-8 Crohn's disease; CESC cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg03709012 chr19:19516395 GATAD2A 1.01 15.7 0.69 1.01e-39 Tonsillectomy; CESC cis rs7084402 0.967 rs7098606 chr10:60277089 C/T cg07615347 chr10:60278583 BICC1 -0.6 -9.67 -0.51 3.99e-19 Refractive error; CESC cis rs559928 0.606 rs17773078 chr11:63906224 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 6.06 0.35 4.55e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC trans rs7307889 0.793 rs7314675 chr12:6018045 C/T cg18407955 chr7:158110685 PTPRN2 -0.78 -6.69 -0.38 1.34e-10 Obesity-related traits; CESC cis rs1728785 1.000 rs1170442 chr16:68574064 G/T cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg15445000 chr17:37608096 MED1 0.41 6.83 0.39 5.8200000000000003e-11 Glomerular filtration rate (creatinine); CESC cis rs12900413 0.603 rs4448912 chr15:90299690 G/A cg24249390 chr15:90295951 MESP1 -0.37 -5.08 -0.3 7.2e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs2637266 1.000 rs12783273 chr10:78353221 T/C cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg19163074 chr7:65112434 INTS4L2 0.52 5.33 0.31 2.13e-7 Aortic root size; CESC cis rs950776 0.518 rs56007453 chr15:78826239 T/C cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs12042052 1.000 rs72752168 chr1:232922800 G/A cg06935979 chr1:232941706 KIAA1383 0.62 5.48 0.32 9.65e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs668210 0.793 rs1151514 chr11:65758854 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.69 7.56 0.42 6.56e-13 Cerebrospinal fluid biomarker levels; CESC trans rs11992162 1.000 rs12334769 chr8:11833161 A/T cg15556689 chr8:8085844 FLJ10661 0.54 6.25 0.36 1.64e-9 Monocyte count; CESC cis rs2576037 0.583 rs9960463 chr18:44522808 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.56 0.61 1.06e-28 Personality dimensions; CESC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg07395648 chr5:131743802 NA -0.45 -6.04 -0.35 5.29e-9 Blood metabolite levels; CESC cis rs3857536 0.741 rs9363556 chr6:66934399 T/C cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs3733585 0.781 rs13103879 chr4:9972879 T/C cg00071950 chr4:10020882 SLC2A9 -0.77 -13.74 -0.64 8.54e-33 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg02297831 chr4:17616191 MED28 0.56 6.82 0.39 6.21e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs748404 0.723 rs565658 chr15:43556307 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.92 0.44 6.42e-14 Lung cancer; CESC cis rs523522 0.962 rs509445 chr12:121017243 A/C cg12219531 chr12:120966889 COQ5 0.77 10.16 0.53 1.1e-20 High light scatter reticulocyte count; CESC cis rs2072499 1.000 rs2253809 chr1:156172125 T/C cg24450063 chr1:156163899 SLC25A44 1.08 22.47 0.81 2.52e-63 Testicular germ cell tumor; CESC cis rs9858542 0.537 rs56038006 chr3:49362369 C/T cg00383909 chr3:49044727 WDR6 0.57 5.12 0.3 5.94e-7 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2292884 0.505 rs78063959 chr2:238428961 G/A cg14458575 chr2:238380390 NA 0.53 5.68 0.33 3.53e-8 Prostate cancer; CESC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Parkinson's disease; CESC cis rs4474465 0.688 rs10793336 chr11:78281867 A/G cg27205649 chr11:78285834 NARS2 0.48 6.24 0.36 1.72e-9 Alzheimer's disease (survival time); CESC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg23708337 chr7:1209742 NA 0.55 5.33 0.31 2.08e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg11890956 chr21:40555474 PSMG1 0.96 15.87 0.7 2.49e-40 Cognitive function; CESC cis rs7918232 0.941 rs1753415 chr10:27395102 T/C cg14240646 chr10:27532245 ACBD5 -0.68 -6.35 -0.36 9.2e-10 Breast cancer; CESC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg12463550 chr7:65579703 CRCP 0.49 6.17 0.35 2.57e-9 Aortic root size; CESC cis rs12145833 0.665 rs78871868 chr1:243422322 C/T cg02356786 chr1:243265016 LOC731275 0.77 5.8 0.34 1.93e-8 Obesity (early onset extreme); CESC cis rs6495122 0.699 rs1378940 chr15:75083494 C/A cg14664628 chr15:75095509 CSK -0.67 -9.26 -0.49 7.44e-18 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs2996428 0.667 rs72640928 chr1:3768568 T/C cg13057898 chr1:3703894 LRRC47 0.45 6.15 0.35 2.83e-9 Red cell distribution width; CESC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg07414643 chr4:187882934 NA 0.47 6.85 0.39 5.26e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg12463550 chr7:65579703 CRCP 0.56 6.94 0.39 3.07e-11 Aortic root size; CESC cis rs7904368 0.806 rs7900527 chr10:16857992 C/G cg23933602 chr10:16859644 RSU1 0.66 6.13 0.35 3.15e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs67311347 0.544 rs9821440 chr3:40342347 T/C cg09455208 chr3:40491958 NA 0.37 6.49 0.37 4.2e-10 Renal cell carcinoma; CESC cis rs10791323 0.575 rs4489760 chr11:133732265 A/T cg15485101 chr11:133734466 NA 0.39 6.59 0.38 2.4e-10 Childhood ear infection; CESC cis rs523522 0.962 rs7471 chr12:120941215 T/C cg12219531 chr12:120966889 COQ5 0.75 9.97 0.52 4.31e-20 High light scatter reticulocyte count; CESC cis rs4319547 0.956 rs10773302 chr12:123043145 G/T cg23029597 chr12:123009494 RSRC2 -0.45 -5.13 -0.3 5.58e-7 Body mass index; CESC cis rs8092503 1.000 rs3764512 chr18:52495324 G/T cg12377874 chr18:52495404 RAB27B 0.36 5.67 0.33 3.64e-8 Childhood body mass index; CESC cis rs3749237 0.595 rs1464567 chr3:49459252 C/G cg06212747 chr3:49208901 KLHDC8B -0.52 -7.03 -0.4 1.72e-11 Resting heart rate; CESC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg26839252 chr6:160211577 TCP1;MRPL18 0.49 6.15 0.35 2.83e-9 Age-related macular degeneration (geographic atrophy); CESC cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 3.05e-8 Mean platelet volume; CESC cis rs67311347 0.956 rs11714871 chr3:40428938 T/G cg09455208 chr3:40491958 NA 0.45 7.5 0.42 9.87e-13 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20235901 chr18:34409524 KIAA1328;C18orf10 -0.53 -6.16 -0.35 2.62e-9 Gut microbiome composition (summer); CESC cis rs6964587 0.904 rs2023785 chr7:91547369 C/A cg17063962 chr7:91808500 NA -0.52 -6.87 -0.39 4.7e-11 Breast cancer; CESC cis rs17376456 1.000 rs17376207 chr5:93545524 C/T cg21475434 chr5:93447410 FAM172A -0.83 -7.48 -0.42 1.1e-12 Diabetic retinopathy; CESC cis rs2228479 0.557 rs2293584 chr16:89888686 C/G cg04013166 chr16:89971882 TCF25 0.73 5.77 0.33 2.2e-8 Skin colour saturation; CESC cis rs17376456 0.809 rs10476602 chr5:93445255 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.66 0.33 4.02e-8 Diabetic retinopathy; CESC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg11494091 chr17:61959527 GH2 0.73 12.49 0.61 1.88e-28 Prudent dietary pattern; CESC cis rs3125734 0.633 rs12217669 chr10:63988456 A/G cg09941381 chr10:64027924 RTKN2 0.31 5.1 0.3 6.62e-7 Rheumatoid arthritis; CESC cis rs35110281 0.627 rs7282704 chr21:44966253 A/G cg04455712 chr21:45112962 RRP1B 0.35 5.08 0.3 7.29e-7 Mean corpuscular volume; CESC cis rs9300255 0.544 rs2049114 chr12:123657338 T/C cg00376283 chr12:123451042 ABCB9 0.71 8.65 0.47 4.88e-16 Neutrophil percentage of white cells; CESC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg26119090 chr2:26468346 HADHA;HADHB 1.08 11.71 0.58 8.22e-26 Gut microbiome composition (summer); CESC cis rs2204008 0.774 rs8186954 chr12:38318566 C/A cg13010199 chr12:38710504 ALG10B 0.42 5.3 0.31 2.42e-7 Bladder cancer; CESC cis rs727505 0.866 rs67724276 chr7:124719719 G/A cg23710748 chr7:124431027 NA -0.4 -6.51 -0.37 3.76e-10 Lewy body disease; CESC cis rs6493487 0.512 rs7179865 chr15:51108951 A/G cg02338191 chr15:51200825 AP4E1 -0.52 -5.04 -0.3 8.51e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs10504229 0.511 rs16921553 chr8:57979314 T/C cg22535103 chr8:58192502 C8orf71 -0.71 -7.13 -0.4 9.56e-12 Developmental language disorder (linguistic errors); CESC cis rs9302635 0.816 rs7202323 chr16:72217113 T/G cg01557791 chr16:72042693 DHODH -0.58 -6.25 -0.36 1.66e-9 Blood protein levels; CESC cis rs17818399 0.645 rs35870739 chr2:46784231 A/C cg06386533 chr2:46925753 SOCS5 0.48 5.28 0.31 2.7e-7 Height; CESC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg23161317 chr6:28129485 ZNF389 0.53 6.51 0.37 3.8e-10 Depression; CESC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg15782153 chr7:917662 C7orf20 -0.49 -5.24 -0.31 3.25e-7 Cerebrospinal P-tau181p levels; CESC cis rs7937682 0.883 rs659529 chr11:111436896 T/A cg09085632 chr11:111637200 PPP2R1B -0.97 -14.3 -0.66 8.89e-35 Primary sclerosing cholangitis; CESC trans rs66573146 0.831 rs56031152 chr4:6973832 C/A cg07817883 chr1:32538562 TMEM39B 1.25 8.46 0.46 1.88e-15 Granulocyte percentage of myeloid white cells; CESC cis rs10129255 0.500 rs9324092 chr14:107139823 A/G cg07958169 chr14:107095056 NA 0.58 9.22 0.49 9.67e-18 Kawasaki disease; CESC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs868036 0.881 rs12708496 chr15:68054098 T/C cg08079166 chr15:68083412 MAP2K5 -0.42 -6.51 -0.37 3.67e-10 Restless legs syndrome; CESC cis rs7520050 0.933 rs6661163 chr1:46255004 A/G cg06784218 chr1:46089804 CCDC17 -0.3 -5.4 -0.31 1.46e-7 Red blood cell count;Reticulocyte count; CESC cis rs2011503 1.000 rs6511029 chr19:19471419 G/T cg11584989 chr19:19387371 SF4 -0.62 -7.24 -0.41 4.75e-12 Bipolar disorder; CESC cis rs7684253 0.565 rs13130605 chr4:57810071 G/A cg21154227 chr4:57904332 IGFBP7 0.37 5.36 0.31 1.84e-7 Migraine; CESC cis rs1707322 0.827 rs6694302 chr1:46245645 A/T cg06784218 chr1:46089804 CCDC17 0.37 6.27 0.36 1.45e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7312933 0.703 rs10492388 chr12:42608001 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.48 0.37 4.46e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs1371867 0.875 rs1788169 chr8:101326314 C/T cg11906718 chr8:101322791 RNF19A 0.54 6.89 0.39 4.05e-11 Atrioventricular conduction; CESC cis rs8067545 1.000 rs7211535 chr17:19922364 A/G cg13482628 chr17:19912719 NA 0.42 5.63 0.33 4.63e-8 Schizophrenia; CESC cis rs6964587 1.000 rs2282972 chr7:91666369 C/T cg17063962 chr7:91808500 NA 0.6 8.31 0.45 4.96e-15 Breast cancer; CESC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg26939375 chr7:64535504 NA 0.74 10.62 0.55 3.48e-22 Aortic root size; CESC cis rs3026101 0.647 rs4790263 chr17:5307084 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.48 6.36 0.36 8.61e-10 Body mass index; CESC cis rs10206020 0.759 rs11903889 chr2:1576601 C/T cg26248373 chr2:1572462 NA -0.59 -6.93 -0.39 3.22e-11 IgG glycosylation; CESC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.55 0.64 3.99e-32 Prudent dietary pattern; CESC cis rs2985684 1.000 rs56098064 chr14:50105849 T/C cg15316458 chr14:50087796 RPL36AL;MGAT2 0.46 5.31 0.31 2.28e-7 Carotid intima media thickness; CESC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg24829409 chr8:58192753 C8orf71 -0.51 -6.11 -0.35 3.63e-9 Developmental language disorder (linguistic errors); CESC cis rs854765 0.583 rs4925130 chr17:17807858 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.53 7.32 0.41 2.99e-12 Total body bone mineral density; CESC cis rs12893668 0.637 rs12892038 chr14:104068629 G/A cg08213375 chr14:104286397 PPP1R13B 0.33 5.16 0.3 4.79e-7 Reticulocyte count; CESC cis rs1008375 0.900 rs13144986 chr4:17675019 C/A cg16339924 chr4:17578868 LAP3 -0.67 -7.74 -0.43 2.14e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg08736216 chr1:53307985 ZYG11A -0.39 -6.35 -0.36 9.46e-10 Monocyte count; CESC cis rs17376456 0.825 rs35426871 chr5:93291613 C/T cg25358565 chr5:93447407 FAM172A 1.1 10.12 0.53 1.4e-20 Diabetic retinopathy; CESC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg17971929 chr21:40555470 PSMG1 1.03 15.89 0.7 2.13e-40 Cognitive function; CESC cis rs12545109 0.800 rs2576591 chr8:57423606 A/G cg09654669 chr8:57350985 NA -0.54 -6.63 -0.38 1.89e-10 Obesity-related traits; CESC cis rs11122272 0.735 rs2790897 chr1:231491712 C/A cg06096015 chr1:231504339 EGLN1 0.45 6.59 0.38 2.39e-10 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20540608 chr5:60241003 NDUFAF2;ERCC8 0.59 6.21 0.36 1.99e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16371082 chr3:134083158 AMOTL2 -0.48 -6.52 -0.37 3.46e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.68 -0.58 1.06e-25 Alzheimer's disease; CESC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.26 0.41 4.32e-12 Height; CESC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg07395648 chr5:131743802 NA -0.41 -5.24 -0.31 3.31e-7 Acylcarnitine levels; CESC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg19346786 chr7:2764209 NA -0.5 -7.19 -0.4 6.47e-12 Height; CESC cis rs7246657 0.714 rs12972195 chr19:37752505 T/C cg23950597 chr19:37808831 NA -0.58 -6.47 -0.37 4.61e-10 Coronary artery calcification; CESC cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg04166393 chr7:2884313 GNA12 0.39 5.14 0.3 5.3e-7 Height; CESC cis rs2576037 0.583 rs578451 chr18:44404525 T/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.6 0.33 5.37e-8 Personality dimensions; CESC cis rs13242816 1.000 rs34228114 chr7:116106986 C/T cg04696780 chr7:116139425 CAV2 -0.62 -5.69 -0.33 3.31e-8 P wave duration; CESC cis rs67311347 0.544 rs9877105 chr3:40333366 T/C cg24209194 chr3:40518798 ZNF619 0.38 5.2 0.3 3.91e-7 Renal cell carcinoma; CESC trans rs116095464 0.558 rs10068203 chr5:206618 C/T cg00938859 chr5:1591904 SDHAP3 0.66 6.26 0.36 1.55e-9 Breast cancer; CESC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 5.46 0.32 1.11e-7 Tonsillectomy; CESC cis rs62283056 0.512 rs752854 chr4:6281961 C/T cg25554036 chr4:6271136 WFS1 0.5 6.96 0.39 2.59e-11 Cisplatin-induced ototoxicity; CESC trans rs1814175 0.645 rs28839231 chr11:50044292 G/T cg03929089 chr4:120376271 NA -0.91 -14.92 -0.68 5.78e-37 Height; CESC cis rs6752107 0.901 rs2289477 chr2:234160345 T/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.91 0.39 3.59e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs1355223 0.902 rs1539250 chr11:34742775 C/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.43 -0.37 5.9e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg12463550 chr7:65579703 CRCP -0.49 -6.2 -0.36 2.16e-9 Aortic root size; CESC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg24531977 chr5:56204891 C5orf35 -0.88 -11.27 -0.57 2.42e-24 Initial pursuit acceleration; CESC cis rs7605827 0.930 rs4668919 chr2:15662171 C/T cg19274914 chr2:15703543 NA 0.32 5.66 0.33 3.88e-8 Educational attainment (years of education); CESC cis rs2050392 0.929 rs10826798 chr10:30700904 G/A cg18806716 chr10:30721971 MAP3K8 0.43 6.17 0.35 2.55e-9 Inflammatory bowel disease; CESC cis rs2204008 0.837 rs11180482 chr12:38235950 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.52 1.51e-19 Bladder cancer; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg26071963 chr14:88945568 PTPN21 0.47 6.05 0.35 4.95e-9 Recombination measurement; CESC cis rs7945705 0.774 rs6486060 chr11:9024630 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.4 6.87 0.39 4.45e-11 Hemoglobin concentration; CESC cis rs2439831 1.000 rs537115 chr15:43729948 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.82 11.89 0.59 2.04e-26 Lung cancer in ever smokers; CESC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg10691866 chr7:65817282 TPST1 0.31 5.24 0.31 3.34e-7 Aortic root size; CESC cis rs61931739 0.534 rs12372721 chr12:34175301 C/T cg19457237 chr12:34500585 NA -0.4 -5.33 -0.31 2.11e-7 Morning vs. evening chronotype; CESC cis rs1256061 0.624 rs1152577 chr14:64697485 T/G cg23250157 chr14:64679961 SYNE2 0.52 7.37 0.41 2.22e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg11764359 chr7:65958608 NA 0.96 15.25 0.68 3.95e-38 Aortic root size; CESC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.53 6.29 0.36 1.32e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg19592336 chr6:28129416 ZNF389 0.62 8.34 0.46 4.05e-15 Depression; CESC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.43 6.48 0.37 4.56e-10 Cystic fibrosis severity; CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg25405998 chr7:65216604 CCT6P1 0.45 5.89 0.34 1.17e-8 Calcium levels; CESC cis rs9682041 0.932 rs7631221 chr3:170069893 A/G cg11886554 chr3:170076028 SKIL 0.7 6.5 0.37 3.86e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs72781680 1.000 rs7581107 chr2:24173565 C/T cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg13880726 chr7:1868755 MAD1L1 0.5 5.12 0.3 5.91e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16218964 chr11:62473680 BSCL2;GNG3 0.63 7.36 0.41 2.28e-12 Gut microbiome composition (summer); CESC cis rs9325144 0.555 rs4882279 chr12:38688918 C/A cg26384229 chr12:38710491 ALG10B 0.58 8.59 0.47 7.74e-16 Morning vs. evening chronotype; CESC cis rs2050392 0.624 rs303447 chr10:30728464 T/C cg18806716 chr10:30721971 MAP3K8 -0.63 -9.55 -0.51 9.45e-19 Inflammatory bowel disease; CESC trans rs853679 0.546 rs17695758 chr6:27837183 T/C cg21479132 chr6:26055353 NA 0.81 6.09 0.35 4.04e-9 Depression; CESC cis rs6088580 0.634 rs6088484 chr20:32985961 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -6.98 -0.39 2.39e-11 Glomerular filtration rate (creatinine); CESC cis rs12579753 0.917 rs10778834 chr12:82199742 A/C cg24719984 chr12:82153464 PPFIA2 -0.33 -5.09 -0.3 6.86e-7 Resting heart rate; CESC cis rs317689 0.581 rs160829 chr12:69769538 G/C cg20891283 chr12:69753455 YEATS4 0.75 10.04 0.53 2.54e-20 Response to diuretic therapy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25837738 chr7:148725785 PDIA4 -0.46 -6.57 -0.37 2.69e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs66561647 0.597 rs34390452 chr8:128940141 G/A cg05480350 chr8:128972681 MIR1205;PVT1 0.42 5.66 0.33 3.96e-8 Hemoglobin concentration; CESC cis rs36051895 0.554 rs59053556 chr9:5200524 G/A cg02405213 chr9:5042618 JAK2 -0.47 -5.5 -0.32 8.72e-8 Pediatric autoimmune diseases; CESC cis rs1878931 0.696 rs35175748 chr16:3445427 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 1.1 19.25 0.76 2.97e-52 Body mass index (adult); CESC cis rs6460942 1.000 rs6460936 chr7:12404913 T/C cg20607287 chr7:12443886 VWDE -0.79 -8.72 -0.47 3.1e-16 Coronary artery disease; CESC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg05332525 chr7:65337924 VKORC1L1 0.5 6.02 0.35 5.74e-9 Aortic root size; CESC cis rs72627509 0.904 rs56281640 chr4:57765816 G/A cg26694713 chr4:57773883 REST 0.58 5.67 0.33 3.63e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.5 8.65 0.47 5.2e-16 Monocyte percentage of white cells; CESC cis rs9831754 0.906 rs1588650 chr3:78410750 T/G cg06138941 chr3:78371609 NA -0.61 -7.62 -0.42 4.54e-13 Calcium levels; CESC cis rs34779708 0.966 rs34605125 chr10:35411246 A/G cg03585969 chr10:35415529 CREM 0.77 10.12 0.53 1.47e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7264396 0.580 rs2425181 chr20:34447709 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 6.64 0.38 1.77e-10 Total cholesterol levels; CESC cis rs6669072 0.647 rs814544 chr1:91241693 G/A cg08895590 chr1:91227319 NA -0.33 -5.71 -0.33 2.98e-8 Cognitive function; CESC cis rs67311347 1.000 rs11716675 chr3:40485280 G/T cg01475735 chr3:40494733 NA -0.4 -5.05 -0.3 8.35e-7 Renal cell carcinoma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25581932 chr17:7892150 NA 0.43 6.35 0.36 9.37e-10 Gut microbiota (bacterial taxa); CESC cis rs763121 0.853 rs8138996 chr22:39047435 G/T cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs250677 0.687 rs250671 chr5:148446523 T/C cg18129178 chr5:148520854 ABLIM3 -0.51 -5.83 -0.34 1.58e-8 Breast cancer; CESC cis rs12530845 0.623 rs76485854 chr7:135352668 T/C cg23117316 chr7:135346802 PL-5283 -0.59 -6.35 -0.36 9.26e-10 Red blood cell traits; CESC cis rs1707322 0.721 rs7519900 chr1:46234947 C/T cg05343316 chr1:45956843 TESK2 0.52 6.36 0.36 8.66e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11098499 0.909 rs1546502 chr4:120235898 A/G cg09307838 chr4:120376055 NA 0.92 12.74 0.62 2.59e-29 Corneal astigmatism; CESC cis rs9916302 0.752 rs676882 chr17:37433424 A/T cg07936489 chr17:37558343 FBXL20 0.89 8.83 0.48 1.44e-16 Glomerular filtration rate (creatinine); CESC cis rs2243480 0.901 rs73148097 chr7:65431787 A/C cg18252515 chr7:66147081 NA -1.24 -12.17 -0.6 2.31e-27 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07375367 chr13:28194831 POLR1D;LNX2 0.51 6.1 0.35 3.75e-9 Gut microbiome composition (summer); CESC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg00166722 chr3:10149974 C3orf24 0.54 6.89 0.39 4.08e-11 Alzheimer's disease; CESC cis rs9467711 0.659 rs3734542 chr6:26468326 G/A cg21479132 chr6:26055353 NA 0.74 5.4 0.31 1.48e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.7 -0.33 3.23e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg03396347 chr1:1875803 NA 0.42 6.63 0.38 1.87e-10 Body mass index; CESC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.7 8.92 0.48 7.8e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs3733585 0.638 rs6449155 chr4:9956547 T/G cg02734326 chr4:10020555 SLC2A9 -0.41 -5.87 -0.34 1.32e-8 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07228441 chr8:681215 ERICH1 0.57 6.38 0.36 7.81e-10 Gut microbiome composition (summer); CESC cis rs6968419 0.788 rs60671526 chr7:115823069 T/C cg02561103 chr7:115862891 TES -0.39 -5.24 -0.31 3.34e-7 Intraocular pressure; CESC cis rs763014 0.865 rs8909 chr16:633851 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.07 -0.3 7.47e-7 Height; CESC cis rs7795096 0.806 rs10277544 chr7:151540633 T/C cg17008978 chr7:151542804 PRKAG2 0.39 7.25 0.41 4.53e-12 Bipolar disorder (age of onset and psychotic symptoms); CESC trans rs7945705 0.935 rs1883098 chr11:8890594 G/A cg10637292 chr12:52960529 KRT74 0.35 6.23 0.36 1.86e-9 Hemoglobin concentration; CESC cis rs2006771 0.818 rs8142376 chr22:32001037 C/T cg13145458 chr22:31556086 RNF185 0.44 5.43 0.32 1.31e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.49 0.42 1.01e-12 Prudent dietary pattern; CESC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg08470875 chr2:26401718 FAM59B 0.75 7.79 0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs870825 0.616 rs6818447 chr4:185650154 G/A cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.74e-11 Blood protein levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02843535 chr17:18759628 NA 0.45 6.02 0.35 5.8e-9 Systemic lupus erythematosus; CESC cis rs7296418 0.922 rs1727293 chr12:123648032 C/T cg00376283 chr12:123451042 ABCB9 0.67 9.46 0.5 1.75e-18 Platelet count; CESC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg16049864 chr8:95962084 TP53INP1 -0.71 -13.05 -0.63 2.08e-30 Type 2 diabetes; CESC cis rs1788820 0.833 rs1429934 chr18:21162288 C/T cg14672496 chr18:21087552 C18orf8 0.45 6.07 0.35 4.44e-9 Body mass index; CESC cis rs7089973 0.604 rs10490909 chr10:116593532 C/T cg03647239 chr10:116582469 FAM160B1 0.41 5.07 0.3 7.53e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21815536 chr7:35840623 SEPT7 0.62 7.54 0.42 7.57e-13 Gut microbiome composition (summer); CESC cis rs2898681 0.519 rs3811781 chr4:53729166 T/G cg00791764 chr4:53727839 RASL11B 0.43 5.06 0.3 7.75e-7 Optic nerve measurement (cup area); CESC cis rs2243480 1.000 rs7804223 chr7:65664559 T/G cg13147721 chr7:65941812 NA 0.97 9.19 0.49 1.2e-17 Diabetic kidney disease; CESC cis rs155076 0.711 rs4770131 chr13:21897468 A/G cg25811766 chr13:21894605 NA 0.6 5.45 0.32 1.17e-7 White matter hyperintensity burden; CESC cis rs2832191 0.716 rs2249028 chr21:30365322 G/A cg24692254 chr21:30365293 RNF160 1.02 18.35 0.75 4.23e-49 Dental caries; CESC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.13 0.4 9.62e-12 Bipolar disorder; CESC cis rs7617773 0.539 rs35460860 chr3:48392085 A/T cg11946769 chr3:48343235 NME6 0.64 8.04 0.44 2.93e-14 Coronary artery disease; CESC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.68 6.58 0.37 2.47e-10 LDL cholesterol;Cholesterol, total; CESC trans rs1814175 0.509 rs60698301 chr11:49877672 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -6.16 -0.35 2.66e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16988976 chr2:99953032 EIF5B;TXNDC9 -0.59 -6.28 -0.36 1.36e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9522267 0.535 rs9522291 chr13:112233761 T/C cg10483660 chr13:112241077 NA -0.33 -5.79 -0.33 2.04e-8 Hepatitis; CESC cis rs3540 0.557 rs11634314 chr15:91042066 A/C cg22089800 chr15:90895588 ZNF774 -0.62 -8.14 -0.45 1.56e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs2130392 1.000 rs11132254 chr4:185611592 G/T cg21366198 chr4:185655624 MLF1IP -0.51 -6.88 -0.39 4.2e-11 Kawasaki disease; CESC cis rs6430585 0.591 rs3098103 chr2:136656094 T/C cg07169764 chr2:136633963 MCM6 1.17 15.49 0.69 5.74e-39 Corneal structure; CESC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg16325326 chr1:53192061 ZYG11B 0.9 14.85 0.67 1.06e-36 Monocyte count; CESC cis rs7666738 0.830 rs13116691 chr4:98929771 A/C cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg04369109 chr6:150039330 LATS1 -0.43 -5.92 -0.34 1.02e-8 Lung cancer; CESC cis rs4563143 0.502 rs73029061 chr19:29283980 T/A cg12667521 chr19:29218732 NA 0.48 5.92 0.34 1.02e-8 Methadone dose in opioid dependence; CESC cis rs820218 0.770 rs9907115 chr17:73676391 G/A cg01592526 chr17:73663357 RECQL5;SAP30BP -0.42 -5.72 -0.33 2.94e-8 Rotator cuff tears; CESC cis rs9733 0.687 rs12410050 chr1:150857141 A/G cg22823121 chr1:150693482 HORMAD1 -0.37 -5.32 -0.31 2.17e-7 Tonsillectomy; CESC cis rs9467711 0.606 rs9393707 chr6:26362486 T/C cg14345882 chr6:26364793 BTN3A2 0.61 6.49 0.37 4.31e-10 Autism spectrum disorder or schizophrenia; CESC cis rs7296418 0.961 rs10773921 chr12:123541606 C/T cg00376283 chr12:123451042 ABCB9 0.75 11.0 0.56 2.04e-23 Platelet count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11413751 chr19:45458585 CLPTM1 -0.41 -6.16 -0.35 2.69e-9 Gambling; CESC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg26338869 chr17:61819248 STRADA 0.67 8.77 0.47 2.24e-16 Prudent dietary pattern; CESC cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg07636037 chr3:49044803 WDR6 1.05 18.71 0.75 2.31e-50 Parkinson's disease; CESC cis rs6460942 1.000 rs2053382 chr7:12400587 A/G cg13733410 chr7:12443478 VWDE -0.55 -5.43 -0.32 1.26e-7 Coronary artery disease; CESC cis rs2204008 0.774 rs11495721 chr12:38337224 A/C cg26384229 chr12:38710491 ALG10B 0.69 10.42 0.54 1.61e-21 Bladder cancer; CESC cis rs4969178 0.965 rs12451791 chr17:76397343 G/A cg05887092 chr17:76393375 PGS1 0.58 9.22 0.49 9.9e-18 HDL cholesterol levels; CESC cis rs748404 0.660 rs2467738 chr15:43739936 T/A cg27015174 chr15:43622946 ADAL;LCMT2 0.58 7.67 0.43 3.24e-13 Lung cancer; CESC cis rs7085104 0.684 rs7092690 chr10:104609365 T/C cg04362960 chr10:104952993 NT5C2 0.52 6.74 0.38 1.01e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg19717773 chr7:2847554 GNA12 -0.57 -8.36 -0.46 3.61e-15 Height; CESC cis rs1461503 0.932 rs7944492 chr11:122838745 G/T cg27398637 chr11:122830231 C11orf63 -0.57 -8.68 -0.47 4.17e-16 Menarche (age at onset); CESC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg06456125 chr7:65229604 NA 0.44 5.7 0.33 3.19e-8 Calcium levels; CESC cis rs6582630 0.519 rs11495724 chr12:38337507 T/C cg26384229 chr12:38710491 ALG10B 0.71 10.65 0.55 2.77e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg05347473 chr6:146136440 FBXO30 0.57 7.24 0.41 4.72e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs61776719 0.738 rs7555461 chr1:38444749 T/C cg26528311 chr1:38462546 FHL3 -0.41 -6.67 -0.38 1.49e-10 Coronary artery disease; CESC cis rs4566357 0.615 rs12618793 chr2:227909552 T/C cg05526886 chr2:227700861 RHBDD1 -0.45 -5.86 -0.34 1.34e-8 Coronary artery disease; CESC cis rs854765 0.565 rs854768 chr17:18018806 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.29 0.36 1.34e-9 Total body bone mineral density; CESC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg01341218 chr17:43662625 NA 0.9 10.86 0.55 5.9e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9894429 0.966 rs6565604 chr17:79589242 G/A cg18240062 chr17:79603768 NPLOC4 0.73 10.23 0.53 6.51e-21 Eye color traits; CESC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg00149659 chr3:10157352 C3orf10 0.77 9.66 0.51 4.22e-19 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13902409 chr5:179922147 CNOT6 -0.57 -6.07 -0.35 4.5e-9 Gut microbiome composition (summer); CESC cis rs2439831 0.717 rs7165471 chr15:43644788 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.84 12.1 0.6 4.05e-27 Lung cancer in ever smokers; CESC cis rs3820068 0.655 rs59605679 chr1:15863796 T/G cg18192808 chr1:15853278 DNAJC16 0.46 5.63 0.33 4.49e-8 Systolic blood pressure; CESC cis rs72781680 0.898 rs7563564 chr2:23993404 T/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs3820068 0.608 rs2057304 chr1:16017710 A/G cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.35 4.28e-9 Systolic blood pressure; CESC cis rs77106637 0.860 rs75896506 chr11:72429579 G/A cg04827223 chr11:72435913 ARAP1 -0.62 -6.26 -0.36 1.58e-9 Type 2 diabetes; CESC cis rs881375 0.715 rs7858209 chr9:123645760 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 6.09 0.35 4.05e-9 Rheumatoid arthritis; CESC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.77 9.93 0.52 5.72e-20 Height; CESC cis rs7089973 0.836 rs12765350 chr10:116635305 G/A cg23260525 chr10:116636907 FAM160B1 0.37 6.15 0.35 2.84e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4843747 0.671 rs28679286 chr16:88106307 C/T cg06374794 chr16:88002281 BANP 0.39 5.16 0.3 4.78e-7 Menopause (age at onset); CESC cis rs2952156 1.000 rs2643194 chr17:37853048 C/T cg20243544 chr17:37824526 PNMT 0.62 7.48 0.42 1.09e-12 Asthma; CESC cis rs3741151 0.764 rs7101561 chr11:73264219 G/C cg17517138 chr11:73019481 ARHGEF17 1.05 7.73 0.43 2.25e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs2882667 0.537 rs7704790 chr5:138410096 A/C cg22797968 chr5:138629998 MATR3 0.38 5.04 0.3 8.69e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7208859 0.623 rs73269974 chr17:29112384 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.09 19.2 0.76 4.43e-52 Height; CESC cis rs6754311 0.731 rs3754686 chr2:136603276 T/C cg15123519 chr2:136567270 LCT 0.31 5.17 0.3 4.51e-7 Mosquito bite size; CESC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg06420487 chr17:61919686 SMARCD2 0.47 5.59 0.32 5.68e-8 Height; CESC cis rs668210 0.894 rs1786171 chr11:65769809 G/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.49 5.42 0.32 1.31e-7 Cerebrospinal fluid biomarker levels; CESC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg04944784 chr2:26401820 FAM59B -0.95 -10.35 -0.54 2.65e-21 Gut microbiome composition (summer); CESC cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.71 9.04 0.49 3.3e-17 Multiple sclerosis; CESC cis rs9308731 0.591 rs879623 chr2:111946824 G/A cg04202892 chr2:111875749 ACOXL 0.4 5.53 0.32 7.58e-8 Chronic lymphocytic leukemia; CESC cis rs9611565 0.592 rs5996037 chr22:41965292 A/G cg17376030 chr22:41985996 PMM1 0.54 5.98 0.35 7.02e-9 Vitiligo; CESC cis rs3106136 0.546 rs2276910 chr4:95129238 T/C cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.26 -0.49 7.25e-18 Capecitabine sensitivity; CESC cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg08508325 chr11:3079039 CARS -0.51 -9.67 -0.51 3.75e-19 Longevity; CESC cis rs12155623 0.619 rs870397 chr8:49861225 C/T cg00325661 chr8:49890786 NA 0.41 5.64 0.33 4.3e-8 Sudden cardiac arrest; CESC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1775715 0.737 rs1419171 chr10:32214831 C/A cg18675610 chr10:32216311 ARHGAP12 0.36 5.47 0.32 1.04e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6120849 0.754 rs6088678 chr20:33607551 A/G cg24642439 chr20:33292090 TP53INP2 -0.65 -6.47 -0.37 4.79e-10 Protein C levels; CESC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg24642844 chr7:1081250 C7orf50 -0.7 -8.64 -0.47 5.26e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9457247 0.934 rs2345571 chr6:167403400 T/G cg23791538 chr6:167370224 RNASET2 -0.58 -8.19 -0.45 1.1e-14 Crohn's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19000349 chr2:75061841 HK2 -0.44 -6.27 -0.36 1.45e-9 Gambling; CESC cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -5.52 -0.32 7.99e-8 Personality dimensions; CESC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs11676348 0.714 rs4674254 chr2:218986077 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.03 -0.35 5.51e-9 Ulcerative colitis; CESC cis rs754466 0.561 rs67332822 chr10:79706118 G/A cg17075019 chr10:79541650 NA -0.68 -6.31 -0.36 1.16e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg18769074 chr3:133464867 TF -0.31 -5.42 -0.32 1.36e-7 Iron status biomarkers; CESC cis rs4803468 0.935 rs284660 chr19:41932084 G/T cg09537434 chr19:41945824 ATP5SL -1.06 -19.39 -0.77 9.44e-53 Height; CESC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg19748678 chr4:122722346 EXOSC9 0.78 9.68 0.51 3.7e-19 Type 2 diabetes; CESC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg08470875 chr2:26401718 FAM59B -0.65 -7.34 -0.41 2.65e-12 Gut microbiome composition (summer); CESC cis rs11864453 0.680 rs8047377 chr16:72148339 T/C cg16558253 chr16:72132732 DHX38 -0.54 -8.58 -0.47 8.07e-16 Fibrinogen levels; CESC cis rs10779751 0.770 rs11121691 chr1:11181327 C/T cg08854313 chr1:11322531 MTOR -0.73 -8.67 -0.47 4.47e-16 Body mass index; CESC cis rs4654899 0.865 rs61779065 chr1:21356474 A/T cg05370193 chr1:21551575 ECE1 0.43 6.21 0.36 2.09e-9 Superior frontal gyrus grey matter volume; CESC cis rs7589342 0.628 rs35866817 chr2:106402569 T/C cg16077055 chr2:106428750 NCK2 0.54 6.73 0.38 1.07e-10 Addiction; CESC cis rs7945705 0.934 rs1988709 chr11:8882890 A/T cg21881798 chr11:8931708 C11orf17;ST5 0.48 7.56 0.42 6.46e-13 Hemoglobin concentration; CESC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg04248312 chr19:17393744 ANKLE1 -0.93 -15.26 -0.68 3.79e-38 Systemic lupus erythematosus; CESC cis rs4073582 0.595 rs801741 chr11:65917084 A/G cg14036092 chr11:66035641 RAB1B 0.56 7.93 0.44 6e-14 Gout; CESC cis rs11621710 0.898 rs10147080 chr14:35596092 C/A cg16230307 chr14:35515116 FAM177A1 0.53 6.83 0.39 5.95e-11 Granulocyte percentage of myeloid white cells; CESC cis rs6061231 1.000 rs13043313 chr20:60958269 A/G cg24112000 chr20:60950667 NA -0.6 -8.37 -0.46 3.41e-15 Colorectal cancer; CESC cis rs116095464 0.558 rs73031482 chr5:227594 G/A cg10591111 chr5:226296 SDHA -0.53 -6.65 -0.38 1.64e-10 Breast cancer; CESC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg24675658 chr1:53192096 ZYG11B -0.58 -7.39 -0.41 1.97e-12 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19545258 chr7:73703601 CLIP2 0.6 7.01 0.4 2.01e-11 Gut microbiome composition (summer); CESC cis rs6762 0.692 rs7928925 chr11:839155 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.67 -8.65 -0.47 5.11e-16 Mean platelet volume; CESC cis rs1008375 0.931 rs2098151 chr4:17577490 T/C cg02297831 chr4:17616191 MED28 0.5 6.07 0.35 4.52e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs34734847 0.750 rs3829290 chr12:121126438 T/C cg26008908 chr12:120799332 MSI1 0.35 5.43 0.32 1.3e-7 Mean corpuscular volume; CESC cis rs35110281 0.659 rs73367822 chr21:45024252 C/T cg04455712 chr21:45112962 RRP1B 0.41 6.11 0.35 3.58e-9 Mean corpuscular volume; CESC trans rs2727020 0.757 rs7924526 chr11:49267043 G/A cg15704280 chr7:45808275 SEPT13 0.81 11.1 0.56 9.45e-24 Coronary artery disease; CESC cis rs7264396 0.790 rs6060542 chr20:34249061 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 3.14e-26 Total cholesterol levels; CESC cis rs11785400 0.731 rs4294163 chr8:143730830 G/T cg10596483 chr8:143751796 JRK 0.42 5.33 0.31 2.06e-7 Schizophrenia; CESC cis rs7914558 1.000 rs7896547 chr10:104866958 A/G cg04362960 chr10:104952993 NT5C2 0.46 5.92 0.34 9.98e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg21782813 chr7:2030301 MAD1L1 0.4 5.76 0.33 2.28e-8 Schizophrenia; CESC cis rs10751667 0.961 rs7479171 chr11:926809 G/A cg20946044 chr11:1010712 AP2A2 -0.43 -5.65 -0.33 4.21e-8 Alzheimer's disease (late onset); CESC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.49 -0.37 4.23e-10 Depression; CESC cis rs7116495 1.000 rs656640 chr11:71781710 T/C cg26138937 chr11:71823887 C11orf51 -0.84 -6.79 -0.38 7.37e-11 Severe influenza A (H1N1) infection; CESC cis rs9902453 0.845 rs3102558 chr17:28023142 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.53 0.46 1.15e-15 Coffee consumption (cups per day); CESC cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg15541040 chr2:3486749 NA -0.42 -5.46 -0.32 1.11e-7 Neurofibrillary tangles; CESC cis rs11098499 1.000 rs6837898 chr4:120179154 C/T cg09307838 chr4:120376055 NA 0.87 11.47 0.58 5.45e-25 Corneal astigmatism; CESC cis rs1506636 1.000 rs767637 chr7:123321978 C/A cg03229431 chr7:123269106 ASB15 -0.51 -6.78 -0.38 7.66e-11 Plateletcrit;Platelet count; CESC cis rs644799 0.540 rs10831419 chr11:95478037 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.46 5.85 0.34 1.45e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7582720 1.000 rs72932557 chr2:203846817 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs1814175 0.645 rs1851850 chr11:50012168 G/A cg03929089 chr4:120376271 NA -0.9 -14.56 -0.67 1.12e-35 Height; CESC cis rs7666738 0.606 rs6839946 chr4:99076132 A/C cg05340658 chr4:99064831 C4orf37 0.67 9.37 0.5 3.33e-18 Colonoscopy-negative controls vs population controls; CESC cis rs7084402 0.967 rs1365741 chr10:60277489 C/T cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC cis rs2228479 0.850 rs62054638 chr16:89821131 G/C cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -5.55 -0.32 6.83e-8 Monocyte percentage of white cells; CESC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.67 0.33 3.77e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12478296 1.000 rs6743297 chr2:243013814 A/G cg06360820 chr2:242988706 NA -0.78 -9.78 -0.51 1.78e-19 Obesity-related traits; CESC cis rs7772486 0.875 rs7739371 chr6:146424353 C/G cg05347473 chr6:146136440 FBXO30 0.51 6.75 0.38 9.04e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs8078723 0.668 rs56030650 chr17:38131187 C/A cg17467752 chr17:38218738 THRA 0.58 8.49 0.46 1.49e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs2404602 0.692 rs12904198 chr15:77146978 G/A cg22467129 chr15:76604101 ETFA -0.35 -5.23 -0.31 3.42e-7 Blood metabolite levels; CESC cis rs11122272 0.735 rs2808595 chr1:231526238 G/A cg06096015 chr1:231504339 EGLN1 0.42 5.96 0.34 8.07e-9 Hemoglobin concentration; CESC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg22974920 chr21:40686053 BRWD1 -0.47 -5.66 -0.33 3.83e-8 Cognitive function; CESC cis rs12458462 0.892 rs58675823 chr18:77463672 G/A cg23301140 chr18:77439876 CTDP1 0.58 7.78 0.43 1.6e-13 Monocyte count; CESC cis rs6460942 0.597 rs7798779 chr7:12543490 A/G cg20607287 chr7:12443886 VWDE -0.7 -7.29 -0.41 3.65e-12 Coronary artery disease; CESC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg23803603 chr1:2058230 PRKCZ 0.3 5.14 0.3 5.36e-7 Height; CESC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg27266027 chr21:40555129 PSMG1 0.47 5.84 0.34 1.53e-8 Cognitive function; CESC cis rs10489525 0.560 rs10858062 chr1:115602563 A/G cg01522456 chr1:115632236 TSPAN2 0.5 6.03 0.35 5.63e-9 Autism; CESC cis rs892961 0.777 rs747483 chr17:75412091 C/T cg05865280 chr17:75406074 SEPT9 0.62 12.7 0.62 3.53e-29 Airflow obstruction; CESC cis rs2191566 0.576 rs397683 chr19:44494054 A/G cg20607764 chr19:44506953 ZNF230 0.4 5.12 0.3 5.92e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs17376456 0.877 rs12716457 chr5:93397627 T/C cg21475434 chr5:93447410 FAM172A 0.79 6.99 0.39 2.2e-11 Diabetic retinopathy; CESC cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg12386194 chr3:101231763 SENP7 0.41 5.13 0.3 5.65e-7 Colorectal cancer; CESC cis rs1670533 1.000 rs10084890 chr4:1053934 C/G cg27284194 chr4:1044797 NA -0.47 -5.93 -0.34 9.34e-9 Recombination rate (females); CESC cis rs7264396 0.635 rs6121102 chr20:34544274 A/G cg17201900 chr20:34330562 RBM39 0.5 5.21 0.3 3.88e-7 Total cholesterol levels; CESC cis rs7584330 0.910 rs880930 chr2:238396872 G/C cg11271282 chr2:238384023 NA 0.48 5.6 0.33 5.34e-8 Prostate cancer; CESC trans rs11252926 0.528 rs11252090 chr10:436547 C/T cg00953403 chr17:74099816 EXOC7 -0.58 -7.4 -0.41 1.77e-12 Psychosis in Alzheimer's disease; CESC cis rs11098499 0.908 rs2017057 chr4:120257711 A/G cg24375607 chr4:120327624 NA 0.46 5.76 0.33 2.36e-8 Corneal astigmatism; CESC cis rs17376456 0.935 rs13156002 chr5:93508931 G/A cg25358565 chr5:93447407 FAM172A 1.18 11.54 0.58 3.22e-25 Diabetic retinopathy; CESC cis rs753778 0.667 rs10103731 chr8:142206068 C/T cg18755752 chr8:142205143 DENND3 -0.63 -9.03 -0.48 3.72e-17 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7917772 0.619 rs2251772 chr10:104470918 T/C cg04362960 chr10:104952993 NT5C2 -0.47 -5.14 -0.3 5.46e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs55823223 0.648 rs936393 chr17:73847613 A/G cg06969265 chr17:73775802 H3F3B 0.6 6.56 0.37 2.74e-10 Psoriasis; CESC cis rs7560272 0.538 rs4852977 chr2:73938295 C/T cg20560298 chr2:73613845 ALMS1 0.41 5.63 0.33 4.5e-8 Schizophrenia; CESC cis rs2479724 0.776 rs2250428 chr6:41832772 T/A cg08135965 chr6:41755394 TOMM6 0.41 5.5 0.32 9.15e-8 Menarche (age at onset); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01375172 chr16:23464338 COG7 -0.49 -6.62 -0.38 1.98e-10 Height; CESC cis rs1707322 1.000 rs10890359 chr1:46336635 A/G cg05343316 chr1:45956843 TESK2 0.43 5.23 0.31 3.41e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9457247 1.000 rs364451 chr6:167384756 G/A cg25258033 chr6:167368657 RNASET2 0.38 5.73 0.33 2.73e-8 Crohn's disease; CESC trans rs1814175 0.645 rs10128731 chr11:50023554 G/T cg15704280 chr7:45808275 SEPT13 -1.0 -18.53 -0.75 9.55e-50 Height; CESC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg11764359 chr7:65958608 NA -0.94 -15.05 -0.68 1.96e-37 Aortic root size; CESC cis rs7193541 0.826 rs56143602 chr16:74694692 T/C cg01733217 chr16:74700730 RFWD3 0.92 13.43 0.64 1.06e-31 Multiple myeloma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25275331 chr1:40723935 ZMPSTE24 0.67 7.94 0.44 5.72e-14 Gut microbiome composition (summer); CESC cis rs4481887 0.741 rs4360554 chr1:248553206 C/T cg26353448 chr1:248524236 OR2T4 -0.37 -5.23 -0.31 3.46e-7 Common traits (Other); CESC trans rs1814175 0.645 rs28441045 chr11:50048971 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -18.7 -0.75 2.39e-50 Height; CESC cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg00255919 chr5:131827918 IRF1 -0.61 -10.9 -0.56 4.22e-23 Asthma (sex interaction); CESC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg18350739 chr11:68623251 NA -0.47 -7.42 -0.41 1.61e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg10845886 chr2:3471009 TTC15 -0.61 -8.25 -0.45 7.51e-15 Neurofibrillary tangles; CESC cis rs941408 0.515 rs12610096 chr19:2778129 C/T cg02580895 chr19:2754563 NA -0.41 -5.25 -0.31 3.07e-7 Total cholesterol levels; CESC cis rs9811920 0.609 rs704583 chr3:99643693 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs12824058 0.737 rs11060829 chr12:130814996 G/T cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg10253484 chr15:75165896 SCAMP2 -0.51 -6.97 -0.39 2.5e-11 Breast cancer; CESC cis rs6430585 1.000 rs73958618 chr2:136500475 A/G cg07169764 chr2:136633963 MCM6 1.03 13.14 0.63 1.02e-30 Corneal structure; CESC cis rs9486715 0.867 rs9384602 chr6:96919561 G/A cg06623918 chr6:96969491 KIAA0776 0.95 14.79 0.67 1.64e-36 Headache; CESC cis rs941408 0.515 rs7253128 chr19:2776982 C/T cg02580895 chr19:2754563 NA -0.48 -6.49 -0.37 4.25e-10 Total cholesterol levels; CESC cis rs897080 0.515 rs786405 chr2:44710367 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.52 0.32 8.26e-8 Height; CESC cis rs367943 0.698 rs728915 chr5:112995748 C/T cg12552261 chr5:112820674 MCC 0.45 5.35 0.31 1.87e-7 Type 2 diabetes; CESC cis rs7927592 0.763 rs7120876 chr11:68261398 C/G cg01657329 chr11:68192670 LRP5 -0.46 -6.06 -0.35 4.62e-9 Total body bone mineral density; CESC trans rs11098499 0.754 rs1980025 chr4:120252806 A/G cg25214090 chr10:38739885 LOC399744 -0.59 -8.33 -0.46 4.28e-15 Corneal astigmatism; CESC cis rs1153858 1.000 rs7169818 chr15:45640191 G/A cg21132104 chr15:45694354 SPATA5L1 0.76 10.18 0.53 9.28e-21 Homoarginine levels; CESC cis rs13040088 1.000 rs13040088 chr20:61549202 A/G cg23096297 chr20:61557774 DIDO1 0.95 10.83 0.55 7.11e-23 Menopause (age at onset); CESC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg19468946 chr17:37922297 IKZF3 0.39 5.03 0.3 8.9e-7 Glomerular filtration rate (creatinine); CESC cis rs13336428 0.730 rs28653458 chr16:1525850 T/C cg07835181 chr16:1525278 CLCN7 0.72 9.86 0.52 9.78e-20 Bone mineral density; CESC cis rs854765 0.583 rs6502627 chr17:17849671 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs2991971 0.810 rs2356413 chr1:45914048 A/T cg24296786 chr1:45957014 TESK2 -0.62 -8.77 -0.47 2.21e-16 High light scatter reticulocyte count; CESC cis rs79976124 0.837 rs12201218 chr6:66653619 C/T cg07460842 chr6:66804631 NA -0.7 -8.49 -0.46 1.5e-15 Type 2 diabetes; CESC cis rs858239 1.000 rs156421 chr7:23312487 A/G cg23682824 chr7:23144976 KLHL7 0.43 5.69 0.33 3.41e-8 Cerebrospinal fluid biomarker levels; CESC cis rs2412488 0.853 rs35089837 chr4:54354341 C/T cg22241045 chr4:54363911 LNX1 -0.37 -5.22 -0.31 3.58e-7 DNA methylation (variation); CESC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg25319279 chr11:5960081 NA 0.33 5.14 0.3 5.25e-7 DNA methylation (variation); CESC cis rs6963495 0.745 rs73192152 chr7:105212258 A/C cg02135003 chr7:105160482 PUS7 -0.48 -5.51 -0.32 8.52e-8 Bipolar disorder (body mass index interaction); CESC cis rs7555523 0.830 rs4656460 chr1:165672367 A/C cg24409356 chr1:165738333 TMCO1 0.8 6.7 0.38 1.25e-10 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs13102973 0.965 rs11099306 chr4:135895674 A/G cg14419869 chr4:135874104 NA 0.34 5.33 0.31 2.13e-7 Subjective well-being; CESC cis rs1215050 0.740 rs700740 chr4:98976003 A/C cg17366294 chr4:99064904 C4orf37 -0.38 -5.04 -0.3 8.72e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs72901758 0.768 rs1567237 chr17:76246294 A/G cg26068271 chr17:76253126 NA -0.49 -7.46 -0.42 1.22e-12 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs9612 1.000 rs346528 chr19:44259232 G/T cg08581076 chr19:44259116 C19orf61 0.52 6.14 0.35 2.96e-9 Exhaled nitric oxide output; CESC cis rs12540874 0.698 rs10899736 chr7:50546925 C/T cg18232548 chr7:50535776 DDC -0.4 -5.84 -0.34 1.51e-8 Systemic sclerosis; CESC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.72 0.38 1.12e-10 Electroencephalogram traits; CESC cis rs6088590 1.000 rs28542147 chr20:33376323 G/A cg08999081 chr20:33150536 PIGU 0.59 8.99 0.48 4.71e-17 Coronary artery disease; CESC cis rs9902453 0.765 rs2250320 chr17:28128657 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg24675658 chr1:53192096 ZYG11B -0.7 -9.41 -0.5 2.53e-18 Monocyte count; CESC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg04398451 chr17:18023971 MYO15A 0.73 10.31 0.54 3.55e-21 Total body bone mineral density; CESC cis rs2243480 1.000 rs160642 chr7:65558373 C/T cg13147721 chr7:65941812 NA -0.98 -9.11 -0.49 2.06e-17 Diabetic kidney disease; CESC cis rs7917772 0.636 rs7894154 chr10:104524647 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -5.18 -0.3 4.3e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg17949981 chr6:28129498 ZNF389 -0.43 -5.34 -0.31 2e-7 Parkinson's disease; CESC cis rs911555 0.713 rs10162425 chr14:103931621 C/T cg12935359 chr14:103987150 CKB -0.58 -8.34 -0.46 4.23e-15 Intelligence (multi-trait analysis); CESC cis rs9640161 0.742 rs11767726 chr7:150018096 A/C cg10018233 chr7:150070692 REPIN1 -0.49 -8.01 -0.44 3.72e-14 Blood protein levels;Circulating chemerin levels; CESC cis rs12142240 0.698 rs7548675 chr1:46809321 C/G cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs2559856 1.000 rs10745921 chr12:102087193 A/G cg15068132 chr12:102092402 CHPT1 -0.39 -5.18 -0.3 4.38e-7 Blood protein levels; CESC cis rs2046867 0.774 rs62249873 chr3:72907115 G/A cg25664220 chr3:72788482 NA -0.49 -7.04 -0.4 1.63e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs2425143 1.000 rs111597121 chr20:34371913 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 8.09e-12 Blood protein levels; CESC cis rs3126085 1.000 rs72696952 chr1:152172694 A/T cg03465714 chr1:152285911 FLG 0.45 5.06 0.3 8.03e-7 Atopic dermatitis; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg16143763 chr17:41116517 AARSD1 0.5 6.44 0.37 5.62e-10 Breast cancer;Type 2 diabetes; CESC cis rs9486719 0.895 rs12527021 chr6:97025496 C/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.7 -0.33 3.16e-8 Migraine;Coronary artery disease; CESC cis rs4664304 0.802 rs3749114 chr2:160832996 A/T cg03641300 chr2:160917029 PLA2R1 -0.51 -7.32 -0.41 3.04e-12 Crohn's disease;Inflammatory bowel disease; CESC cis rs10979 0.928 rs9496676 chr6:143895610 A/G cg25407410 chr6:143891975 LOC285740 -0.6 -9.11 -0.49 2.12e-17 Hypospadias; CESC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg04553112 chr3:125709451 NA -0.52 -5.47 -0.32 1.05e-7 Blood pressure (smoking interaction); CESC cis rs6445797 0.632 rs2291501 chr3:56654141 C/T cg13792233 chr3:56591045 CCDC66 0.38 5.14 0.3 5.29e-7 Gastritis; CESC cis rs6831352 0.734 rs2602856 chr4:100029145 C/A cg12011299 chr4:100065546 ADH4 0.64 8.19 0.45 1.15e-14 Alcohol dependence; CESC cis rs4450798 0.793 rs9882340 chr3:13755427 G/C cg05589046 chr3:13742034 LOC285375 0.38 5.72 0.33 2.94e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs12477438 0.501 rs17759607 chr2:99737005 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 13.0 0.62 3.21e-30 Chronic sinus infection; CESC cis rs2652822 0.509 rs8468 chr15:63434110 C/T cg02713581 chr15:63449717 RPS27L 0.45 5.27 0.31 2.79e-7 Metabolic traits; CESC cis rs2688608 0.592 rs11000758 chr10:75493610 A/T cg23231163 chr10:75533350 FUT11 -0.34 -5.28 -0.31 2.75e-7 Inflammatory bowel disease; CESC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg08736216 chr1:53307985 ZYG11A 0.3 5.05 0.3 8.16e-7 Monocyte count; CESC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs1595825 0.838 rs80172713 chr2:198508044 T/C cg10820045 chr2:198174542 NA 0.42 5.15 0.3 5.02e-7 Ulcerative colitis; CESC trans rs8099014 1.000 rs9946396 chr18:56107163 G/A cg06677321 chr17:67603831 NA 0.43 6.15 0.35 2.89e-9 Platelet count; CESC cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg13298116 chr11:62369859 EML3;MTA2 0.65 9.53 0.51 1.02e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9400467 0.506 rs11153281 chr6:111594594 C/T cg15721981 chr6:111408429 SLC16A10 0.53 5.11 0.3 6.28e-7 Blood metabolite levels;Amino acid levels; CESC cis rs62458065 0.513 rs787216 chr7:32578891 G/A cg20159608 chr7:32802032 NA -0.55 -6.15 -0.35 2.89e-9 Metabolite levels (HVA/MHPG ratio); CESC trans rs2797160 0.904 rs1739370 chr6:126011231 C/T cg05039488 chr6:79577232 IRAK1BP1 0.48 6.45 0.37 5.41e-10 Endometrial cancer; CESC cis rs10504229 0.636 rs77691549 chr8:58055126 G/T cg22535103 chr8:58192502 C8orf71 -0.77 -8.01 -0.44 3.74e-14 Developmental language disorder (linguistic errors); CESC trans rs11098499 0.908 rs12504149 chr4:120318577 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.7 0.51 3.1400000000000002e-19 Corneal astigmatism; CESC cis rs7208859 0.725 rs9891656 chr17:29243355 A/T cg19761014 chr17:28927070 LRRC37B2 0.59 5.88 0.34 1.21e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs941873 0.772 rs1892498 chr10:81103862 A/G cg09469691 chr10:81107165 PPIF 0.5 6.6 0.38 2.28e-10 Height; CESC cis rs533581 0.789 rs7404039 chr16:88975954 A/G cg16701003 chr16:89028210 CBFA2T3 0.55 8.38 0.46 3.21e-15 Social autistic-like traits; CESC cis rs748404 0.586 rs2584700 chr15:43685332 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.54 8.07 0.44 2.44e-14 Lung cancer; CESC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg10053473 chr17:62856997 LRRC37A3 -0.73 -7.89 -0.44 7.89e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2074038 1.000 rs2074038 chr11:44087989 G/T cg15894661 chr11:44088124 ACCS -0.69 -5.47 -0.32 1.03e-7 IgA nephropathy; CESC cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg27478167 chr7:817139 HEATR2 -0.48 -5.25 -0.31 3.11e-7 Cerebrospinal P-tau181p levels; CESC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg05564831 chr3:52568323 NT5DC2 0.45 6.91 0.39 3.55e-11 Bipolar disorder; CESC cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.05 0.35 4.95e-9 Colorectal cancer; CESC cis rs9916302 0.904 rs7503069 chr17:37697128 C/G cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.89e-10 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03562744 chr8:27168757 TRIM35;PTK2B 0.57 6.4 0.37 6.85e-10 Gut microbiome composition (summer); CESC cis rs7267979 0.565 rs4815437 chr20:25584788 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.69 -11.07 -0.56 1.14e-23 Liver enzyme levels (alkaline phosphatase); CESC cis rs12220238 1.000 rs11000924 chr10:75972311 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.45 0.32 1.13e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg17340268 chr14:105411764 AHNAK2 -0.52 -6.8 -0.39 6.73e-11 Rheumatoid arthritis; CESC cis rs11098499 0.874 rs6822498 chr4:120120183 T/C cg09307838 chr4:120376055 NA 0.74 9.31 0.5 5.18e-18 Corneal astigmatism; CESC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs959260 0.557 rs12936583 chr17:73304710 A/C cg20590849 chr17:73267439 MIF4GD 0.45 5.64 0.33 4.32e-8 Systemic lupus erythematosus; CESC cis rs59918340 0.936 rs6982449 chr8:142234642 T/C cg23750338 chr8:142222470 SLC45A4 -0.41 -6.38 -0.37 7.65e-10 Immature fraction of reticulocytes; CESC cis rs11997175 0.716 rs7460818 chr8:33816362 A/G ch.8.33884649F chr8:33765107 NA 0.66 9.06 0.49 3.02e-17 Body mass index; CESC cis rs12545109 0.571 rs4237014 chr8:57284479 C/A cg09654669 chr8:57350985 NA -0.48 -5.86 -0.34 1.41e-8 Obesity-related traits; CESC cis rs2933343 0.679 rs1091938 chr3:128637025 T/C cg11901034 chr3:128598214 ACAD9 -0.37 -5.37 -0.31 1.71e-7 IgG glycosylation; CESC cis rs67311347 0.544 rs2887965 chr3:40334154 A/G cg24209194 chr3:40518798 ZNF619 -0.39 -5.38 -0.31 1.62e-7 Renal cell carcinoma; CESC cis rs7607369 0.536 rs13032993 chr2:219666377 T/C cg02176678 chr2:219576539 TTLL4 -0.35 -6.05 -0.35 5.04e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs7772486 0.875 rs864390 chr6:146315035 G/T cg23711669 chr6:146136114 FBXO30 0.77 10.98 0.56 2.36e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs4909189 1.000 rs12698214 chr7:158136204 T/G cg24154853 chr7:158122151 PTPRN2 0.51 6.44 0.37 5.73e-10 Response to amphetamines; CESC cis rs7100689 0.646 rs7092237 chr10:82165640 A/G cg00277334 chr10:82204260 NA -0.43 -6.05 -0.35 4.98e-9 Post bronchodilator FEV1; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17436946 chr4:39699568 UBE2K 0.47 6.16 0.35 2.74e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs12477438 0.501 rs6727749 chr2:99793590 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.62 0.61 6.6e-29 Chronic sinus infection; CESC cis rs73019876 0.869 rs8101183 chr19:22170551 C/A cg11619707 chr19:22235551 ZNF257 -0.28 -5.13 -0.3 5.6e-7 Testicular germ cell tumor; CESC cis rs708547 0.671 rs1718863 chr4:57887586 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -5.52 -0.32 8.06e-8 Response to bleomycin (chromatid breaks); CESC cis rs1879734 0.689 rs6695509 chr1:54161112 A/G cg23596471 chr1:54105337 GLIS1 0.35 5.56 0.32 6.52e-8 Mitral valve prolapse; CESC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg00990874 chr7:1149470 C7orf50 -0.48 -5.12 -0.3 5.9e-7 Bronchopulmonary dysplasia; CESC cis rs7116495 0.609 rs4245463 chr11:71743213 C/A cg07596299 chr11:71824057 C11orf51 -0.86 -5.2 -0.3 3.99e-7 Severe influenza A (H1N1) infection; CESC cis rs9399135 0.967 rs7741515 chr6:135374368 C/G cg22676075 chr6:135203613 NA -0.5 -6.96 -0.39 2.61e-11 Red blood cell count; CESC cis rs2243480 1.000 rs313820 chr7:65574466 A/C cg12463550 chr7:65579703 CRCP 0.74 5.77 0.33 2.23e-8 Diabetic kidney disease; CESC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg17971929 chr21:40555470 PSMG1 1.04 15.63 0.69 1.78e-39 Cognitive function; CESC cis rs12478296 1.000 rs56323081 chr2:243040807 A/G cg06360820 chr2:242988706 NA -0.86 -8.97 -0.48 5.46e-17 Obesity-related traits; CESC cis rs17023223 0.581 rs11811859 chr1:119707680 A/G cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.35e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs4948102 0.727 rs4948097 chr7:56056571 A/G cg09872392 chr7:56161020 PHKG1 -0.46 -7.17 -0.4 7.37e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs6662572 0.737 rs77017199 chr1:46532407 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 5.25 0.31 3.18e-7 Blood protein levels; CESC cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg25894440 chr7:65020034 NA -0.61 -5.09 -0.3 6.78e-7 Diabetic kidney disease; CESC cis rs8060686 0.641 rs12598256 chr16:68084021 G/A cg26727032 chr16:67993705 SLC12A4 -0.54 -6.16 -0.35 2.65e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg02869306 chr7:64672164 INTS4L1 -0.37 -5.77 -0.33 2.16e-8 Calcium levels; CESC cis rs12912251 0.947 rs7171233 chr15:38988760 T/A cg01338139 chr15:38987640 C15orf53 -0.47 -5.43 -0.32 1.26e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03051979 chr16:58283909 CCDC113 -0.43 -6.03 -0.35 5.55e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4835473 0.900 rs13105571 chr4:144655394 C/T cg25736465 chr4:144833511 NA -0.32 -5.04 -0.3 8.48e-7 Immature fraction of reticulocytes; CESC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg00484396 chr16:3507460 NAT15 0.6 6.53 0.37 3.32e-10 Tuberculosis; CESC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg00750074 chr16:89608354 SPG7 -0.42 -6.16 -0.35 2.66e-9 Multiple myeloma (IgH translocation); CESC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg04414720 chr1:150670196 GOLPH3L 0.45 5.96 0.34 8.13e-9 Melanoma; CESC cis rs1707322 0.686 rs2275085 chr1:46085852 C/T cg03146154 chr1:46216737 IPP -0.79 -10.85 -0.55 6.39e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16922275 chr15:59063609 FAM63B 0.56 6.37 0.36 8.26e-10 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs1812843 chr5:267658 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.49 0.32 9.44e-8 Breast cancer; CESC cis rs5769707 0.967 rs5769698 chr22:49997706 A/G cg05373962 chr22:49881684 NA -0.36 -6.29 -0.36 1.29e-9 Monocyte count;Monocyte percentage of white cells; CESC cis rs365132 1.000 rs353478 chr5:176370988 T/C cg16309518 chr5:176445507 NA -0.37 -5.36 -0.31 1.77e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg25809561 chr17:30822961 MYO1D 0.56 7.73 0.43 2.19e-13 Schizophrenia; CESC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg04166393 chr7:2884313 GNA12 0.59 7.57 0.42 6.3e-13 Height; CESC cis rs17253792 0.731 rs3736876 chr14:56120178 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.65 0.33 4.2e-8 Putamen volume; CESC cis rs6088580 0.634 rs1205338 chr20:32925625 C/G cg08999081 chr20:33150536 PIGU -0.64 -11.05 -0.56 1.39e-23 Glomerular filtration rate (creatinine); CESC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.45 0.42 1.34e-12 Tonsillectomy; CESC cis rs708547 0.874 rs1614251 chr4:57891386 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.52 -5.43 -0.32 1.27e-7 Response to bleomycin (chromatid breaks); CESC cis rs7267979 0.744 rs6050463 chr20:25208990 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.72 12.67 0.61 4.3e-29 Liver enzyme levels (alkaline phosphatase); CESC cis rs7020830 0.898 rs7038219 chr9:37182892 C/A cg14294708 chr9:37120828 ZCCHC7 1.1 20.4 0.78 2.91e-56 Schizophrenia; CESC cis rs2295499 0.553 rs17164088 chr4:2675893 A/G cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.2 -0.3 3.96e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs67311347 1.000 rs6762997 chr3:40478151 C/T cg09455208 chr3:40491958 NA 0.46 8.05 0.44 2.79e-14 Renal cell carcinoma; CESC cis rs1062177 1.000 rs41494545 chr5:151235094 A/G cg12924095 chr5:151150029 G3BP1 -0.48 -6.42 -0.37 6.21e-10 Preschool internalizing problems; CESC cis rs9399135 0.967 rs4896121 chr6:135293645 T/C cg24558204 chr6:135376177 HBS1L 0.51 6.77 0.38 8.2e-11 Red blood cell count; CESC cis rs12477438 0.508 rs2516832 chr2:99771268 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.46 0.69 7.45e-39 Chronic sinus infection; CESC cis rs36051895 0.554 rs11789744 chr9:5134213 G/A cg02405213 chr9:5042618 JAK2 -0.5 -5.92 -0.34 1.01e-8 Pediatric autoimmune diseases; CESC cis rs7833790 0.929 rs10958048 chr8:82792914 C/T cg02079420 chr8:82753780 SNX16 -0.56 -7.56 -0.42 6.68e-13 Diastolic blood pressure; CESC cis rs1008375 0.931 rs10939734 chr4:17570709 C/T cg16339924 chr4:17578868 LAP3 0.74 9.62 0.51 5.34e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7809950 0.953 rs2237670 chr7:107131485 A/G cg23024343 chr7:107201750 COG5 -0.42 -5.86 -0.34 1.37e-8 Coronary artery disease; CESC cis rs7555523 0.887 rs4657475 chr1:165687175 T/C cg24409356 chr1:165738333 TMCO1 0.76 6.98 0.39 2.44e-11 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs2017305 0.834 rs12266901 chr10:70783522 T/C cg01024728 chr10:70782572 NA 0.56 5.38 0.31 1.67e-7 Depression (quantitative trait); CESC cis rs62158211 0.565 rs2121243 chr2:114099346 C/T cg17784749 chr2:114082611 LOC440839 0.55 7.12 0.4 1.04e-11 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CESC cis rs12188164 0.543 rs2672722 chr5:453567 G/A cg16584290 chr5:462447 EXOC3 0.48 7.3 0.41 3.28e-12 Cystic fibrosis severity; CESC cis rs1008375 0.966 rs2302393 chr4:17654341 G/A cg16339924 chr4:17578868 LAP3 0.58 7.23 0.41 5.33e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg06766960 chr11:133703094 NA -0.38 -5.33 -0.31 2.15e-7 Childhood ear infection; CESC cis rs6545883 0.929 rs1186700 chr2:61663372 A/C cg15711740 chr2:61764176 XPO1 -0.4 -5.18 -0.3 4.35e-7 Tuberculosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23183521 chr12:57146030 PRIM1 -0.47 -6.32 -0.36 1.08e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25228755 chr3:142315566 PLS1 -0.53 -6.15 -0.35 2.85e-9 Gut microbiome composition (summer); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg11050527 chr8:54755511 ATP6V1H -0.45 -6.21 -0.36 1.98e-9 Height; CESC cis rs9911578 1.000 rs437732 chr17:56675861 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC cis rs7582720 1.000 rs1541853 chr2:203835177 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs9929218 0.581 rs4783676 chr16:68801077 A/C cg02972257 chr16:68554789 NA -0.42 -5.3 -0.31 2.41e-7 Colorectal cancer; CESC cis rs2243480 1.000 rs34974928 chr7:65364006 T/C cg13147721 chr7:65941812 NA -0.83 -7.97 -0.44 4.85e-14 Diabetic kidney disease; CESC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.77 0.38 8.38e-11 Bipolar disorder; CESC cis rs9858542 0.953 rs11719996 chr3:49525958 T/C cg03060546 chr3:49711283 APEH -0.54 -6.12 -0.35 3.44e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs12142240 0.698 rs41293273 chr1:46806393 T/C cg10495392 chr1:46806563 NSUN4 0.59 6.36 0.36 8.9e-10 Menopause (age at onset); CESC cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg00149659 chr3:10157352 C3orf10 1.0 11.96 0.59 1.22e-26 Alzheimer's disease; CESC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC cis rs11608355 0.515 rs11611012 chr12:109945203 G/A cg05360138 chr12:110035743 NA 0.8 7.82 0.43 1.29e-13 Neuroticism; CESC cis rs35955747 0.633 rs2006771 chr22:31998612 G/A cg25791279 chr22:32026902 PISD -0.46 -5.52 -0.32 7.95e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs763121 1.000 rs1946990 chr22:38912771 C/T cg06022373 chr22:39101656 GTPBP1 -0.76 -11.87 -0.59 2.48e-26 Menopause (age at onset); CESC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.77 0.65 6.55e-33 Prudent dietary pattern; CESC cis rs698813 0.604 rs12712917 chr2:44482190 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.61 0.33 5.15e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg12262378 chr17:6899522 ALOX12 -0.35 -5.64 -0.33 4.29e-8 Tonsillectomy; CESC cis rs7914558 0.901 rs1926034 chr10:104829102 G/A cg15744005 chr10:104629667 AS3MT -0.33 -5.27 -0.31 2.88e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg18225595 chr11:63971243 STIP1 0.74 10.31 0.53 3.67e-21 Platelet count; CESC cis rs11785400 0.762 rs4401833 chr8:143739731 A/T cg10596483 chr8:143751796 JRK 0.42 5.31 0.31 2.32e-7 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01830674 chr2:219433148 RQCD1;USP37 -0.48 -6.01 -0.35 6.2e-9 Ulcerative colitis; CESC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg04772025 chr11:68637568 NA 0.52 6.14 0.35 3.05e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.800 rs12163918 chr4:98835794 T/C cg17366294 chr4:99064904 C4orf37 0.52 7.04 0.4 1.6e-11 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 0.754 rs3102382 chr16:89409742 C/G cg02187348 chr16:89574699 SPG7 0.46 5.95 0.34 8.64e-9 Multiple myeloma (IgH translocation); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27005181 chr13:20208413 MPHOSPH8 0.51 6.84 0.39 5.56e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.65 7.91 0.44 7.16e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27295716 chr12:118542069 VSIG10 0.51 6.53 0.37 3.39e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6121246 0.567 rs7361893 chr20:30200751 C/T cg13852791 chr20:30311386 BCL2L1 0.66 6.54 0.37 3.19e-10 Mean corpuscular hemoglobin; CESC trans rs17685 0.753 rs4573217 chr7:75733946 G/A cg19862616 chr7:65841803 NCRNA00174 0.87 12.7 0.62 3.58e-29 Coffee consumption;Coffee consumption (cups per day); CESC trans rs2119507 0.556 rs7567271 chr2:104671174 A/T cg06678084 chr11:65600739 SNX32 -0.52 -6.37 -0.36 8.41e-10 Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms); CESC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.26 0.31 3e-7 Menopause (age at onset); CESC cis rs12477438 0.520 rs4851188 chr2:99745898 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.89 0.62 7.96e-30 Chronic sinus infection; CESC cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.29 0.45 5.87e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs72781680 0.821 rs72781644 chr2:24209348 T/C cg08917208 chr2:24149416 ATAD2B 0.64 6.22 0.36 1.95e-9 Lymphocyte counts; CESC cis rs12541635 0.966 rs6987512 chr8:106998770 C/T cg10147462 chr8:107024639 NA 0.38 5.4 0.31 1.51e-7 Age of smoking initiation; CESC cis rs7520050 0.778 rs12404197 chr1:46232420 G/A cg03146154 chr1:46216737 IPP -0.5 -6.6 -0.38 2.2e-10 Red blood cell count;Reticulocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20683799 chr1:63989117 ITGB3BP;EFCAB7 -0.45 -6.02 -0.35 5.74e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Urate levels; CESC cis rs1062177 1.000 rs62377945 chr5:151208004 C/G cg00977110 chr5:151150581 G3BP1 0.63 6.72 0.38 1.12e-10 Preschool internalizing problems; CESC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg04369109 chr6:150039330 LATS1 -0.43 -6.03 -0.35 5.6e-9 Lung cancer; CESC cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg20503657 chr10:835505 NA -0.77 -7.72 -0.43 2.42e-13 Eosinophil percentage of granulocytes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg13497155 chr3:50374949 RASSF1 -0.49 -6.25 -0.36 1.68e-9 Asthma; CESC cis rs6565180 0.926 rs8046445 chr16:30386262 A/G cg17640201 chr16:30407289 ZNF48 -0.92 -14.91 -0.68 6.18e-37 Tonsillectomy; CESC cis rs4718428 0.672 rs12530806 chr7:66390724 A/G cg18252515 chr7:66147081 NA -0.46 -5.2 -0.3 3.95e-7 Corneal structure; CESC cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg10845886 chr2:3471009 TTC15 -0.67 -9.11 -0.49 2.05e-17 Neurofibrillary tangles; CESC cis rs6142102 0.602 rs10485503 chr20:32557842 A/G cg08999081 chr20:33150536 PIGU 0.33 5.08 0.3 6.99e-7 Skin pigmentation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09378105 chr7:100895380 NA -0.44 -6.1 -0.35 3.74e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00867453 chr9:88555863 NAA35 -0.47 -6.08 -0.35 4.25e-9 Height; CESC cis rs10883723 0.810 rs7079810 chr10:104243883 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.14 0.3 5.47e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs67311347 1.000 rs12638199 chr3:40475285 A/G cg24209194 chr3:40518798 ZNF619 0.46 5.99 0.35 6.9e-9 Renal cell carcinoma; CESC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg00484396 chr16:3507460 NAT15 -0.45 -7.24 -0.41 4.88e-12 Tuberculosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14522427 chr10:73533468 CDH23;C10orf54 0.58 6.41 0.37 6.49e-10 Gut microbiome composition (summer); CESC cis rs9303401 0.538 rs35454383 chr17:56475599 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 9.58 0.51 7.16e-19 Cognitive test performance; CESC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg12163867 chr12:51592794 POU6F1 -0.52 -6.9 -0.39 3.92e-11 Cisplatin-induced ototoxicity; CESC cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg03433033 chr1:76189801 ACADM -0.62 -7.16 -0.4 8.01e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3741489 1.000 rs2306545 chr12:133419296 G/A cg01499426 chr12:133417423 CHFR 0.9 5.59 0.32 5.77e-8 Cognitive function; CESC cis rs853679 1.000 rs13200462 chr6:28218199 A/C cg12740337 chr6:28058973 ZSCAN12L1 0.32 5.03 0.3 9.18e-7 Depression; CESC trans rs1814175 0.817 rs4881658 chr11:49941123 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -20.29 -0.78 6.84e-56 Height; CESC cis rs6542838 0.611 rs6742047 chr2:99531460 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -5.95 -0.34 8.33e-9 Fear of minor pain; CESC cis rs68170813 0.559 rs10487271 chr7:106898458 T/C cg02696742 chr7:106810147 HBP1 -0.52 -5.09 -0.3 6.84e-7 Coronary artery disease; CESC cis rs662064 0.963 rs10864459 chr1:10563609 C/T cg20482658 chr1:10539492 PEX14 0.3 5.99 0.35 6.9e-9 Asthma; CESC cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2075371 0.863 rs12707139 chr7:133954153 A/G cg00033643 chr7:134001901 SLC35B4 0.4 5.14 0.3 5.22e-7 Mean platelet volume; CESC cis rs6662572 1.000 rs6662572 chr1:46146812 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.53 5.83 0.34 1.65e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05340489 chr16:50775671 CYLD -0.57 -6.64 -0.38 1.72e-10 Gut microbiome composition (summer); CESC cis rs17125944 0.556 rs7152229 chr14:53313405 T/C cg00686598 chr14:53173677 PSMC6 -0.73 -6.43 -0.37 5.93e-10 Alzheimer's disease (late onset); CESC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg24733560 chr20:60626293 TAF4 0.45 6.47 0.37 4.62e-10 Body mass index; CESC cis rs7267979 0.932 rs431579 chr20:25470056 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.77 0.67 2.04e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs9486719 1.000 rs10457159 chr6:96993139 G/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.83 -0.34 1.64e-8 Migraine;Coronary artery disease; CESC cis rs3820928 0.869 rs2396436 chr2:227795464 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.75 -0.33 2.46e-8 Pulmonary function; CESC cis rs9611565 0.694 rs5758411 chr22:42079734 G/A cg06481639 chr22:41940642 POLR3H 0.46 5.33 0.31 2.06e-7 Vitiligo; CESC cis rs4409675 0.597 rs1467464 chr1:28211650 T/C cg23691781 chr1:28212827 C1orf38 0.29 5.74 0.33 2.62e-8 Corneal astigmatism; CESC cis rs9323205 0.861 rs56137183 chr14:51693463 C/A cg23942311 chr14:51606299 NA -0.46 -5.82 -0.34 1.73e-8 Cancer; CESC cis rs1707322 0.963 rs12022335 chr1:46402732 C/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs5769765 1.000 rs768618 chr22:50286827 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.2 -0.3 4.05e-7 Schizophrenia; CESC cis rs9660992 0.710 rs1668869 chr1:205239779 G/C cg21643547 chr1:205240462 TMCC2 -0.47 -6.34 -0.36 1.01e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg03452623 chr4:187889614 NA -0.88 -16.31 -0.71 7.08e-42 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.818 rs398812 chr6:145817271 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2050392 0.590 rs685319 chr10:30719331 G/A cg18806716 chr10:30721971 MAP3K8 -0.63 -9.25 -0.49 7.67e-18 Inflammatory bowel disease; CESC cis rs7772486 0.790 rs7753833 chr6:146161432 C/A cg05347473 chr6:146136440 FBXO30 0.56 7.3 0.41 3.39e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.69 -0.33 3.41e-8 Depression; CESC cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg26597838 chr10:835615 NA 0.72 6.49 0.37 4.21e-10 Eosinophil percentage of granulocytes; CESC cis rs2549003 1.000 rs2549005 chr5:131827191 C/T cg21138405 chr5:131827807 IRF1 0.45 5.72 0.33 2.84e-8 Asthma (sex interaction); CESC cis rs7923609 0.967 rs3999089 chr10:65203808 C/T cg01631684 chr10:65280961 REEP3 0.43 5.36 0.31 1.84e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs727505 1.000 rs28844358 chr7:124562695 A/C cg23710748 chr7:124431027 NA -0.47 -7.43 -0.42 1.47e-12 Lewy body disease; CESC cis rs763014 0.833 rs3743902 chr16:632728 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg15793563 chr11:910950 CHID1 -0.41 -6.26 -0.36 1.5e-9 Breast cancer; CESC cis rs1109430 0.661 rs72649921 chr1:210112077 C/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.96 6.89 0.39 4.16e-11 Orofacial clefts; CESC cis rs6460942 0.908 rs73677559 chr7:12270819 A/C cg20607287 chr7:12443886 VWDE -0.56 -5.91 -0.34 1.07e-8 Coronary artery disease; CESC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg08888203 chr3:10149979 C3orf24 0.53 6.83 0.39 5.8200000000000003e-11 Alzheimer's disease; CESC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg18305652 chr10:134549665 INPP5A 0.46 6.35 0.36 9.4e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs11630290 0.736 rs4777239 chr15:64148098 T/A cg12036633 chr15:63758958 NA 0.56 5.89 0.34 1.17e-8 Iris characteristics; CESC cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs74781061 0.929 rs8028430 chr15:74845745 A/G cg17294928 chr15:75287854 SCAMP5 -0.48 -5.15 -0.3 5.08e-7 Endometriosis; CESC cis rs9916302 0.861 rs752314 chr17:37410700 C/T cg15445000 chr17:37608096 MED1 0.41 6.59 0.38 2.34e-10 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16985259 chr1:44412491 IPO13 0.63 7.04 0.4 1.63e-11 Gut microbiome composition (summer); CESC cis rs6032067 0.602 rs2741523 chr20:43920446 C/T cg10761708 chr20:43804764 PI3 0.39 5.04 0.3 8.82e-7 Blood protein levels; CESC cis rs2486288 0.656 rs7171312 chr15:45570225 C/G cg21132104 chr15:45694354 SPATA5L1 -0.57 -6.66 -0.38 1.55e-10 Glomerular filtration rate; CESC cis rs8072100 0.713 rs8075058 chr17:45482857 A/G cg25173405 chr17:45401733 C17orf57 -0.44 -5.48 -0.32 9.7e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs8067354 0.645 rs2665403 chr17:57889985 G/A cg13753209 chr17:57696993 CLTC 0.56 6.3 0.36 1.21e-9 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26330088 chr7:77427924 PHTF2;TMEM60 0.6 6.37 0.36 8.55e-10 Gut microbiome composition (summer); CESC cis rs11677370 0.603 rs10164826 chr2:3849951 G/C cg17052675 chr2:3827356 NA -0.43 -5.5 -0.32 8.9e-8 Type 2 diabetes; CESC cis rs3820068 0.581 rs56128111 chr1:15928948 T/G cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs11098499 0.708 rs1546506 chr4:120241240 T/C cg09307838 chr4:120376055 NA 0.79 10.57 0.54 5.11e-22 Corneal astigmatism; CESC cis rs11203032 1.000 rs11203031 chr10:90964395 G/T cg16672925 chr10:90967113 CH25H 0.73 7.36 0.41 2.33e-12 Heart failure; CESC cis rs9457247 0.967 rs447042 chr6:167405435 C/T cg25258033 chr6:167368657 RNASET2 0.39 5.89 0.34 1.15e-8 Crohn's disease; CESC cis rs3008870 1.000 rs12041926 chr1:67434602 A/G cg02640540 chr1:67518911 SLC35D1 0.5 5.4 0.31 1.47e-7 Lymphocyte percentage of white cells; CESC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.13 -0.35 3.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7208859 0.623 rs9915546 chr17:29132144 G/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs796364 0.806 rs74266489 chr2:201005732 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -6.48 -0.37 4.47e-10 Schizophrenia; CESC cis rs7267979 1.000 rs6050544 chr20:25320228 T/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -16.77 -0.72 1.62e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs9888739 1.000 rs73534420 chr16:31311374 G/T cg15817542 chr16:31343056 ITGAM -0.41 -5.32 -0.31 2.25e-7 Systemic lupus erythematosus; CESC cis rs1048238 0.506 rs10737911 chr1:16167855 C/T cg22431228 chr1:16359049 CLCNKA 0.36 6.46 0.37 5e-10 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14777817 chr13:80055594 NDFIP2 0.59 7.22 0.41 5.61e-12 Gut microbiome composition (summer); CESC cis rs4722166 0.630 rs6461667 chr7:22796743 A/G cg05265849 chr7:22767390 IL6 0.53 6.33 0.36 1.06e-9 Lung cancer; CESC cis rs3733585 0.577 rs5014939 chr4:9953253 T/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6088580 0.524 rs6087616 chr20:33263033 T/C cg08999081 chr20:33150536 PIGU -0.43 -6.02 -0.35 5.65e-9 Glomerular filtration rate (creatinine); CESC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg25767906 chr1:53392781 SCP2 0.42 5.74 0.33 2.58e-8 Monocyte count; CESC cis rs4835473 0.897 rs1817027 chr4:144634489 C/T cg25736465 chr4:144833511 NA -0.45 -6.81 -0.39 6.71e-11 Immature fraction of reticulocytes; CESC cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg14784868 chr12:69753453 YEATS4 0.82 12.52 0.61 1.43e-28 Blood protein levels; CESC trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg17143192 chr8:8559678 CLDN23 -0.6 -6.95 -0.39 2.9100000000000002e-11 Neuroticism; CESC cis rs4132509 0.744 rs12021907 chr1:243995640 A/G cg21452805 chr1:244014465 NA -0.65 -7.26 -0.41 4.2e-12 RR interval (heart rate); CESC cis rs6840258 0.760 rs10032244 chr4:87917931 C/T cg08197287 chr4:87952173 AFF1 -0.35 -5.17 -0.3 4.56e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.47 6.05 0.35 5.05e-9 Tonsillectomy; CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg09033563 chr22:24373618 LOC391322 -0.41 -5.34 -0.31 1.97e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2762353 0.526 rs6912391 chr6:25710763 C/G cg25753631 chr6:25732923 NA 0.26 5.13 0.3 5.49e-7 Blood metabolite levels; CESC cis rs7851660 0.809 rs9299258 chr9:100666543 T/G cg13688889 chr9:100608707 NA -0.63 -8.95 -0.48 6.33e-17 Strep throat; CESC cis rs9291683 0.595 rs11722930 chr4:10035454 G/A cg00071950 chr4:10020882 SLC2A9 0.87 15.52 0.69 4.3e-39 Bone mineral density; CESC cis rs1050631 0.564 rs589213 chr18:33743610 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.6 8.4 0.46 2.72e-15 Esophageal squamous cell cancer (length of survival); CESC trans rs9467711 0.606 rs9379857 chr6:26367654 G/C cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC cis rs2718058 0.639 rs2718036 chr7:37775288 T/A cg15028436 chr7:37888078 TXNDC3 0.44 6.01 0.35 6.04e-9 Alzheimer's disease (late onset); CESC cis rs9457247 1.000 rs2013815 chr6:167373812 T/A cg07741184 chr6:167504864 NA -0.3 -5.39 -0.31 1.55e-7 Crohn's disease; CESC cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg17724175 chr1:150552817 MCL1 0.42 6.35 0.36 9.49e-10 Melanoma; CESC cis rs7605378 1.000 rs769954 chr2:200692159 C/G cg23649088 chr2:200775458 C2orf69 -0.53 -7.08 -0.4 1.29e-11 Osteoporosis; CESC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg23708337 chr7:1209742 NA 0.56 5.63 0.33 4.56e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11871801 0.517 rs10454087 chr17:40735641 C/T cg16308533 chr17:40838983 CNTNAP1 0.4 5.19 0.3 4.19e-7 Crohn's disease; CESC cis rs9911578 1.000 rs2611782 chr17:56717956 T/C cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.17e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg02951883 chr7:2050386 MAD1L1 -0.49 -6.61 -0.38 2.11e-10 Bipolar disorder and schizophrenia; CESC cis rs2777491 0.915 rs7178634 chr15:41634587 A/G cg18705301 chr15:41695430 NDUFAF1 -0.6 -9.0 -0.48 4.34e-17 Ulcerative colitis; CESC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs1538970 0.816 rs868351 chr1:46009818 G/T cg06784218 chr1:46089804 CCDC17 0.33 5.46 0.32 1.08e-7 Platelet count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07762761 chr8:104033118 ATP6V1C1 0.43 6.74 0.38 9.84e-11 Gambling; CESC cis rs751837 0.591 rs34407983 chr14:103429786 T/C cg10087771 chr14:103399429 CDC42BPB 0.68 5.95 0.34 8.68e-9 Large B-cell lymphoma; CESC cis rs7552404 0.961 rs211710 chr1:76109038 G/A cg22875332 chr1:76189707 ACADM -0.58 -6.56 -0.37 2.79e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1879734 0.648 rs7549345 chr1:54145288 T/C cg23596471 chr1:54105337 GLIS1 0.34 5.33 0.31 2.07e-7 Mitral valve prolapse; CESC cis rs6460942 0.591 rs62448726 chr7:12330881 A/G cg20607287 chr7:12443886 VWDE -0.63 -6.83 -0.39 5.83e-11 Coronary artery disease; CESC cis rs4144743 1.000 rs7223003 chr17:45324293 G/A cg18085866 chr17:45331354 ITGB3 -0.66 -7.59 -0.42 5.59e-13 Body mass index; CESC trans rs163030 0.902 rs335604 chr5:76750386 T/C cg26150533 chr8:82396069 FABP4 -0.39 -6.0 -0.35 6.37e-9 Caudate nucleus volume; CESC cis rs10089 0.953 rs4835940 chr5:127406596 A/G cg19767477 chr5:127420684 SLC12A2 -0.39 -5.07 -0.3 7.34e-7 Ileal carcinoids; CESC cis rs2361710 0.669 rs12940486 chr17:78118569 T/C cg06718696 chr17:78121285 EIF4A3 0.46 5.44 0.32 1.24e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CESC cis rs2274273 0.837 rs10131913 chr14:55787420 A/G cg04306507 chr14:55594613 LGALS3 0.32 6.38 0.36 8.01e-10 Protein biomarker; CESC cis rs7520050 0.966 rs6675946 chr1:46371774 G/T cg24296786 chr1:45957014 TESK2 0.44 5.58 0.32 5.79e-8 Red blood cell count;Reticulocyte count; CESC cis rs12822507 0.732 rs4763855 chr12:12767758 C/A cg11838227 chr12:12764436 CREBL2 0.42 5.64 0.33 4.27e-8 Systemic lupus erythematosus; CESC cis rs7248779 0.532 rs10153475 chr19:2413961 G/C cg22729335 chr19:2427816 TIMM13 1.13 20.19 0.78 1.62e-55 Cortisol levels (saliva); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01330391 chr1:26324448 PAFAH2 -0.48 -6.32 -0.36 1.08e-9 Height; CESC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg11941060 chr3:133502564 NA -0.45 -6.01 -0.35 6.04e-9 Iron status biomarkers; CESC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg08859206 chr1:53392774 SCP2 -0.64 -9.57 -0.51 7.94e-19 Monocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19988671 chr7:155589783 NA -0.39 -6.19 -0.36 2.33e-9 Gambling; CESC cis rs300703 0.719 rs389621 chr2:206636 C/T cg21211680 chr2:198530 NA -0.96 -9.72 -0.51 2.75e-19 Blood protein levels; CESC cis rs7481584 0.581 rs515481 chr11:3047184 A/G cg25174290 chr11:3078921 CARS -0.45 -6.3 -0.36 1.21e-9 Calcium levels; CESC cis rs6582630 0.519 rs8189599 chr12:38280748 A/G cg13010199 chr12:38710504 ALG10B 0.5 6.26 0.36 1.53e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.99 -0.56 2.11e-23 Alzheimer's disease; CESC cis rs36051895 0.589 rs6476945 chr9:5191793 C/T cg02405213 chr9:5042618 JAK2 -0.54 -6.76 -0.38 8.98e-11 Pediatric autoimmune diseases; CESC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC trans rs16875333 0.588 rs7715383 chr5:5350637 C/G cg25408055 chr13:113977663 LAMP1 0.7 6.08 0.35 4.23e-9 Breast cancer; CESC cis rs11190604 1.000 rs6584383 chr10:102303065 C/G cg07080220 chr10:102295463 HIF1AN 0.58 5.52 0.32 8.22e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs4409675 0.576 rs11247705 chr1:28212272 G/A cg11176159 chr1:28213800 NA 0.22 5.09 0.3 6.84e-7 Corneal astigmatism; CESC cis rs12497850 0.931 rs6442130 chr3:48778027 A/G cg06641503 chr3:48959341 ARIH2 -0.37 -5.46 -0.32 1.1e-7 Parkinson's disease; CESC cis rs6456156 0.875 rs55802221 chr6:167517320 G/A cg07741184 chr6:167504864 NA -0.37 -6.61 -0.38 2.11e-10 Primary biliary cholangitis; CESC cis rs1005277 0.579 rs1780122 chr10:38529509 C/A cg25427524 chr10:38739819 LOC399744 -0.7 -10.26 -0.53 5.29e-21 Extrinsic epigenetic age acceleration; CESC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg16405210 chr4:1374714 KIAA1530 0.47 5.97 0.34 7.64e-9 Obesity-related traits; CESC cis rs1801251 1.000 rs12990821 chr2:233617585 C/G cg25237894 chr2:233734115 C2orf82 0.45 7.9 0.44 7.6e-14 Coronary artery disease; CESC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg00684032 chr4:1343700 KIAA1530 0.39 5.43 0.32 1.27e-7 Obesity-related traits; CESC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg24503407 chr1:205819492 PM20D1 -0.8 -13.51 -0.64 5.47e-32 Menarche (age at onset); CESC cis rs1062177 1.000 rs2964585 chr5:151141895 C/T cg12924095 chr5:151150029 G3BP1 0.48 6.15 0.35 2.82e-9 Preschool internalizing problems; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26030974 chr17:45266791 CDC27 -0.47 -6.51 -0.37 3.78e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs76419734 0.510 rs28450989 chr4:106630007 G/C cg24545054 chr4:106630052 GSTCD;INTS12 0.68 8.21 0.45 9.87e-15 Post bronchodilator FEV1; CESC cis rs67478160 0.584 rs12433009 chr14:104196405 C/G cg08213375 chr14:104286397 PPP1R13B 0.37 6.74 0.38 9.63e-11 Schizophrenia; CESC cis rs72627123 0.867 rs17093884 chr14:74482039 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.65 0.33 4.21e-8 Morning vs. evening chronotype; CESC cis rs6963495 0.818 rs73192122 chr7:105171471 G/A cg19920283 chr7:105172520 RINT1 0.69 6.54 0.37 3.15e-10 Bipolar disorder (body mass index interaction); CESC cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg22834771 chr12:69754056 YEATS4 -0.48 -6.46 -0.37 4.9e-10 Blood protein levels; CESC cis rs2487048 0.773 rs2472493 chr9:107695848 G/A cg14470647 chr9:107690075 ABCA1 -0.47 -5.37 -0.31 1.7e-7 Intraocular pressure; CESC cis rs4722166 0.695 rs6946509 chr7:22809490 T/C cg05265849 chr7:22767390 IL6 0.44 6.17 0.35 2.53e-9 Lung cancer; CESC cis rs7633770 0.841 rs11130100 chr3:46679198 A/T cg11219411 chr3:46661640 NA -0.42 -6.49 -0.37 4.14e-10 Coronary artery disease; CESC cis rs8077577 0.708 rs2290502 chr17:18133495 G/A cg16794390 chr17:18148240 FLII -0.45 -6.69 -0.38 1.35e-10 Obesity-related traits; CESC cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.91 0.48 8.46e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs11696501 0.739 rs2235600 chr20:44238299 T/G cg11783356 chr20:44313418 WFDC10B -0.34 -5.26 -0.31 3.02e-7 Brain structure; CESC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs1003719 0.737 rs9974374 chr21:38479885 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.62 0.47 6.19e-16 Eye color traits; CESC cis rs1707322 0.686 rs1541131 chr1:46084934 G/A cg03146154 chr1:46216737 IPP -0.77 -10.61 -0.55 3.67e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9596863 1.000 rs9596858 chr13:54421858 A/G ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs1348850 0.645 rs13431091 chr2:178434615 A/G cg22681709 chr2:178499509 PDE11A -0.52 -6.49 -0.37 4.18e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs12348691 0.503 rs7849497 chr9:100615660 G/C cg13688889 chr9:100608707 NA -0.9 -13.65 -0.64 1.78e-32 Alopecia areata; CESC cis rs3916 0.910 rs7306541 chr12:121130046 A/G cg21892295 chr12:121157589 UNC119B -0.36 -5.32 -0.31 2.2e-7 Urinary metabolites (H-NMR features); CESC cis rs7264396 0.580 rs2064511 chr20:34448810 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.83 9.33 0.5 4.43e-18 Total cholesterol levels; CESC cis rs3096299 0.869 rs748941 chr16:89440754 T/A cg08822215 chr16:89438651 ANKRD11 -0.41 -6.29 -0.36 1.3e-9 Multiple myeloma (IgH translocation); CESC cis rs12618769 0.597 rs11902825 chr2:99129137 T/C cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs6693567 0.565 rs1260404 chr1:150304150 T/A cg09579323 chr1:150459698 TARS2 0.49 6.28 0.36 1.35e-9 Migraine; CESC cis rs11871801 0.517 rs6963 chr17:40731597 A/T cg14558262 chr17:40713999 COASY -0.49 -5.67 -0.33 3.74e-8 Crohn's disease; CESC cis rs13064411 0.696 rs3732803 chr3:113211957 T/C cg18753928 chr3:113234510 CCDC52 -0.5 -5.9 -0.34 1.11e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg11764359 chr7:65958608 NA -0.78 -11.42 -0.57 8.03e-25 Aortic root size; CESC cis rs9479482 1.000 rs9478362 chr6:150340526 T/C cg03788504 chr6:150331562 NA -0.36 -7.03 -0.4 1.72e-11 Alopecia areata; CESC cis rs8114671 0.967 rs6088753 chr20:33768252 C/T cg24642439 chr20:33292090 TP53INP2 0.44 5.37 0.31 1.73e-7 Height; CESC cis rs3820928 0.935 rs10203363 chr2:227896976 C/T cg11843606 chr2:227700838 RHBDD1 -0.49 -6.49 -0.37 4.29e-10 Pulmonary function; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg11993436 chr7:155437098 RBM33 0.46 6.3 0.36 1.25e-9 Bronchopulmonary dysplasia; CESC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg26314531 chr2:26401878 FAM59B -0.83 -9.23 -0.49 8.99e-18 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg11764359 chr7:65958608 NA -0.78 -10.74 -0.55 1.44e-22 Aortic root size; CESC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg21782813 chr7:2030301 MAD1L1 0.44 6.13 0.35 3.23e-9 Bipolar disorder and schizophrenia; CESC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg12648201 chr2:27665141 KRTCAP3 -0.39 -7.07 -0.4 1.39e-11 Total body bone mineral density; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg22373519 chr2:236761021 AGAP1 -0.46 -6.15 -0.35 2.83e-9 Systemic lupus erythematosus; CESC cis rs7247513 0.759 rs8110545 chr19:12754898 C/T cg01871581 chr19:12707946 ZNF490 -0.85 -13.51 -0.64 5.46e-32 Bipolar disorder; CESC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg05890377 chr2:74357713 NA 0.77 10.44 0.54 1.39e-21 Gestational age at birth (maternal effect); CESC cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg14345882 chr6:26364793 BTN3A2 0.41 5.12 0.3 5.79e-7 Intelligence (multi-trait analysis); CESC cis rs9837602 1.000 rs704582 chr3:99571926 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.51 7.09 0.4 1.21e-11 Breast cancer; CESC cis rs7772486 0.790 rs80050589 chr6:146230454 T/C cg23711669 chr6:146136114 FBXO30 -0.94 -13.73 -0.64 9.31e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs7103648 0.897 rs11606287 chr11:47407439 C/A cg20307385 chr11:47447363 PSMC3 0.94 14.8 0.67 1.56e-36 Diastolic blood pressure;Systolic blood pressure; CESC cis rs6785206 1.000 rs2712370 chr3:128425204 C/G cg16766828 chr3:128327626 NA -0.53 -5.28 -0.31 2.66e-7 Lymphocyte percentage of white cells; CESC cis rs4975616 0.836 rs460073 chr5:1336459 T/C cg26373071 chr5:1325741 CLPTM1L 0.43 6.88 0.39 4.26e-11 Lung cancer; CESC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg09699651 chr6:150184138 LRP11 0.4 5.1 0.3 6.34e-7 Lung cancer; CESC cis rs3925075 0.903 rs36100148 chr16:31345023 C/T cg02846316 chr16:31340340 ITGAM 0.42 6.74 0.38 9.88e-11 IgA nephropathy; CESC cis rs72781680 0.898 rs12623079 chr2:24103749 G/A cg08917208 chr2:24149416 ATAD2B 0.93 8.63 0.47 5.68e-16 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20053329 chr13:42535228 KIAA0564 0.59 6.44 0.37 5.63e-10 Gut microbiome composition (summer); CESC cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg02079420 chr8:82753780 SNX16 0.54 7.36 0.41 2.35e-12 Diastolic blood pressure; CESC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg03188948 chr7:1209495 NA 0.71 7.71 0.43 2.51e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7772486 0.790 rs2265472 chr6:146220758 G/C cg05347473 chr6:146136440 FBXO30 0.55 7.05 0.4 1.57e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg20503657 chr10:835505 NA 0.79 7.99 0.44 4.07e-14 Eosinophil percentage of granulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24330485 chr2:207023983 EEF1B2;NDUFS1 0.47 6.22 0.36 1.91e-9 Gut microbiota (bacterial taxa); CESC cis rs1018836 0.828 rs12548806 chr8:91564256 C/T cg16814680 chr8:91681699 NA -0.63 -9.08 -0.49 2.55e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs36051895 0.632 rs10815167 chr9:5150058 A/G cg02405213 chr9:5042618 JAK2 -0.51 -6.4 -0.37 6.99e-10 Pediatric autoimmune diseases; CESC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg05025164 chr4:1340916 KIAA1530 0.91 12.29 0.6 8.61e-28 Longevity; CESC cis rs2249625 0.545 rs2496488 chr6:72875985 A/T cg18830697 chr6:72922368 RIMS1 -0.48 -7.18 -0.4 6.94e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs367615 0.704 rs60538082 chr5:108829101 A/G cg17395555 chr5:108820864 NA 0.64 11.16 0.57 5.88e-24 Colorectal cancer (SNP x SNP interaction); CESC cis rs926938 0.505 rs360593 chr1:115472265 T/G cg12756093 chr1:115239321 AMPD1 0.45 6.18 0.35 2.44e-9 Autism; CESC cis rs6701037 0.555 rs10912898 chr1:175120469 A/G cg00321850 chr1:175162397 KIAA0040 -0.42 -6.28 -0.36 1.4e-9 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25135143 chr10:115934548 MIR2110;C10orf118 -0.64 -7.14 -0.4 8.89e-12 Gut microbiome composition (summer); CESC cis rs7267979 0.966 rs8123949 chr20:25388133 C/T cg08601574 chr20:25228251 PYGB -0.37 -5.37 -0.31 1.76e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.47 0.37 4.74e-10 Electroencephalogram traits; CESC cis rs483180 0.531 rs541503 chr1:120208297 A/G cg19096424 chr1:120255104 PHGDH -0.42 -5.15 -0.3 5.08e-7 Macular telangiectasia type 2; CESC cis rs1348850 0.567 rs1527401 chr2:178522104 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.29 0.41 3.53e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs1814175 0.702 rs4881644 chr11:49786367 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.84 -0.77 2.5e-54 Height; CESC cis rs854765 0.583 rs10048206 chr17:17866897 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC cis rs1003719 0.788 rs2835588 chr21:38462716 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs7089973 0.604 rs10490909 chr10:116593532 C/T cg25233709 chr10:116636983 FAM160B1 0.38 5.99 0.35 6.97e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6032067 0.929 rs17424356 chr20:43804190 A/G cg10761708 chr20:43804764 PI3 0.51 6.06 0.35 4.58e-9 Blood protein levels; CESC cis rs477692 0.637 rs10829598 chr10:131319774 C/G cg05714579 chr10:131428358 MGMT 0.41 5.36 0.31 1.83e-7 Response to temozolomide; CESC trans rs1814175 0.647 rs4881649 chr11:49845560 A/G cg03929089 chr4:120376271 NA -0.71 -9.2 -0.49 1.09e-17 Height; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00261325 chr5:178199408 AACSL -0.45 -6.79 -0.38 7.51e-11 Systemic lupus erythematosus; CESC cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg21433313 chr16:3507492 NAT15 -0.51 -8.11 -0.45 1.85e-14 Tuberculosis; CESC cis rs763121 0.853 rs9610993 chr22:39042818 C/A cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg03467027 chr4:99064603 C4orf37 0.43 5.42 0.32 1.34e-7 Colonoscopy-negative controls vs population controls; CESC trans rs4665809 1.000 rs750451 chr2:26324241 G/A cg09258813 chr8:37823409 ADRB3 -0.37 -6.14 -0.35 2.99e-9 Gut microbiome composition (summer); CESC cis rs1055129 0.537 rs10852766 chr17:73951864 T/C cg02678768 chr17:74002944 EVPL -0.43 -5.84 -0.34 1.55e-8 White matter hyperintensity burden; CESC cis rs992157 0.764 rs4672886 chr2:219185545 C/T cg00012203 chr2:219082015 ARPC2 -0.61 -7.66 -0.43 3.59e-13 Colorectal cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16600119 chr3:129033604 NA 0.43 6.15 0.35 2.77e-9 Systemic lupus erythematosus; CESC cis rs4722166 0.508 rs1474347 chr7:22768124 A/C cg13104385 chr7:22767384 IL6 -0.39 -5.55 -0.32 6.83e-8 Lung cancer; CESC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg11366901 chr6:160182831 ACAT2 0.76 9.31 0.5 4.95e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg26939375 chr7:64535504 NA 0.77 10.93 0.56 3.25e-23 Calcium levels; CESC cis rs2204008 0.837 rs12146734 chr12:38237079 A/G cg13010199 chr12:38710504 ALG10B 0.49 6.1 0.35 3.78e-9 Bladder cancer; CESC cis rs9302635 0.513 rs12444701 chr16:72155240 C/T cg01557791 chr16:72042693 DHODH -0.57 -6.65 -0.38 1.66e-10 Blood protein levels; CESC cis rs258892 0.842 rs34956 chr5:72203696 T/C cg21869765 chr5:72125136 TNPO1 0.44 5.57 0.32 6.25e-8 Small cell lung carcinoma; CESC cis rs3761847 0.500 rs7037673 chr9:123740484 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 5.35 0.31 1.9e-7 Rheumatoid arthritis; CESC cis rs68170813 0.605 rs4730227 chr7:106904031 G/C cg02696742 chr7:106810147 HBP1 -0.54 -5.33 -0.31 2.15e-7 Coronary artery disease; CESC cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg25517755 chr10:38738941 LOC399744 -0.48 -6.27 -0.36 1.42e-9 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00053292 chr17:61678300 TACO1 -0.58 -6.42 -0.37 6.35e-10 Gut microbiome composition (summer); CESC cis rs11809207 0.523 rs2802343 chr1:26498570 T/C cg00147160 chr1:26503991 CNKSR1 0.28 5.28 0.31 2.67e-7 Height; CESC cis rs7937682 0.883 rs1784775 chr11:111472460 T/C cg22437258 chr11:111473054 SIK2 0.74 9.86 0.52 9.59e-20 Primary sclerosing cholangitis; CESC cis rs3204270 0.639 rs11867543 chr17:79655046 C/T cg18367735 chr17:79674897 NA 0.7 5.79 0.34 1.95e-8 Dental caries; CESC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg12463550 chr7:65579703 CRCP 0.59 7.52 0.42 8.29e-13 Aortic root size; CESC trans rs11098499 0.954 rs10014845 chr4:120301077 T/G cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs116095464 0.558 rs28729548 chr5:229025 C/T cg20965017 chr5:231967 SDHA -0.45 -5.08 -0.3 7.29e-7 Breast cancer; CESC cis rs10463316 0.894 rs7727770 chr5:150767116 G/T cg03212797 chr5:150827313 SLC36A1 -0.47 -6.2 -0.36 2.17e-9 Metabolite levels (Pyroglutamine); CESC cis rs7312933 0.558 rs1796394 chr12:42826359 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.5 -6.72 -0.38 1.08e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg00701064 chr4:6280414 WFS1 0.7 11.96 0.59 1.17e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7631605 0.875 rs4678921 chr3:37022803 T/C cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.15 -0.3 5.21e-7 Cerebrospinal P-tau181p levels; CESC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg14298792 chr15:30685198 CHRFAM7A -0.45 -5.39 -0.31 1.55e-7 Huntington's disease progression; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg25987502 chr17:6899865 ALOX12 -0.47 -7.47 -0.42 1.14e-12 Tonsillectomy; CESC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg12463550 chr7:65579703 CRCP 0.55 7.11 0.4 1.07e-11 Aortic root size; CESC cis rs9487051 0.702 rs368467 chr6:109519451 T/C cg01475377 chr6:109611718 NA -0.37 -5.55 -0.32 6.99e-8 Reticulocyte fraction of red cells; CESC cis rs62005083 1.000 rs55878372 chr14:74509023 G/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.7 5.22 0.31 3.68e-7 Mean corpuscular volume; CESC cis rs250677 0.687 rs41181 chr5:148444257 C/G cg18129178 chr5:148520854 ABLIM3 0.51 5.78 0.33 2.09e-8 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03576636 chr19:1918189 SCAMP4 0.49 6.9 0.39 3.91e-11 Fibrinogen levels; CESC cis rs11677416 1.000 rs1878319 chr2:113544826 G/A cg27083787 chr2:113543245 IL1A 0.42 5.28 0.31 2.72e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs116095464 0.510 rs55750776 chr5:230467 T/C cg20965017 chr5:231967 SDHA -0.45 -5.08 -0.3 7.29e-7 Breast cancer; CESC cis rs13064411 0.735 rs6778800 chr3:113149236 A/G cg18753928 chr3:113234510 CCDC52 -0.47 -5.56 -0.32 6.63e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.8 -0.34 1.86e-8 Depression; CESC cis rs9916302 0.706 rs1054488 chr17:37687968 A/G cg20243544 chr17:37824526 PNMT 0.53 5.26 0.31 3.03e-7 Glomerular filtration rate (creatinine); CESC cis rs7937682 0.883 rs12804962 chr11:111442683 A/T cg22437258 chr11:111473054 SIK2 -0.64 -7.89 -0.44 7.79e-14 Primary sclerosing cholangitis; CESC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.26 -0.31 2.92e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs921968 0.613 rs1344642 chr2:219555262 G/A cg02176678 chr2:219576539 TTLL4 -0.47 -8.34 -0.46 4.03e-15 Mean corpuscular hemoglobin concentration; CESC cis rs9911578 0.933 rs2632508 chr17:56533235 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.43 0.32 1.25e-7 Intelligence (multi-trait analysis); CESC cis rs7223966 1.000 rs7209758 chr17:61913621 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.28 0.36 1.35e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs990171 0.607 rs871659 chr2:102771855 C/T cg22835712 chr2:102737379 NA 0.43 6.06 0.35 4.71e-9 Lymphocyte counts; CESC cis rs1568889 1.000 rs11602768 chr11:28351786 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.69 8.16 0.45 1.33e-14 Bipolar disorder; CESC cis rs4568518 0.587 rs4576329 chr7:18007152 A/G cg03009463 chr7:17980271 SNX13 0.44 5.88 0.34 1.2e-8 Measles; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22922770 chr7:98923339 ARPC1A 0.55 6.47 0.37 4.74e-10 Gut microbiome composition (summer); CESC cis rs911555 0.755 rs1138400 chr14:103956833 A/G cg09975044 chr14:104007538 NA 0.43 5.28 0.31 2.68e-7 Intelligence (multi-trait analysis); CESC cis rs2288073 0.619 rs6713263 chr2:24375463 A/G cg01493198 chr2:24299560 SF3B14 0.38 5.15 0.3 5.13e-7 Venous thromboembolism (SNP x SNP interaction); CESC cis rs16854884 0.586 rs4616638 chr3:143735423 A/T cg06585982 chr3:143692056 C3orf58 -0.5 -7.09 -0.4 1.21e-11 Economic and political preferences (feminism/equality); CESC cis rs6750047 0.566 rs1157185 chr2:38285735 C/T cg07380506 chr2:38303506 CYP1B1 0.43 5.6 0.33 5.46e-8 Cutaneous malignant melanoma;Melanoma; CESC cis rs28498503 0.867 rs58491155 chr18:76647526 T/G cg00806245 chr18:76673096 NA -0.63 -5.27 -0.31 2.77e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs17764205 0.568 rs72987040 chr19:3251116 C/A cg02612712 chr19:3985498 EEF2 0.66 5.11 0.3 6.17e-7 Bipolar disorder and schizophrenia; CESC cis rs798554 0.671 rs1182195 chr7:2868730 A/G cg19717773 chr7:2847554 GNA12 -0.55 -8.17 -0.45 1.27e-14 Height; CESC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg22920501 chr2:26401640 FAM59B -0.78 -9.21 -0.49 1.03e-17 Gut microbiome composition (summer); CESC cis rs6088580 0.634 rs6088502 chr20:33037644 A/T cg08999081 chr20:33150536 PIGU 0.66 11.61 0.58 1.85e-25 Glomerular filtration rate (creatinine); CESC cis rs539096 0.500 rs2906457 chr1:44338575 A/C cg12908607 chr1:44402522 ARTN -0.49 -7.59 -0.42 5.52e-13 Intelligence (multi-trait analysis); CESC cis rs11122272 0.735 rs2486743 chr1:231506928 C/G cg06096015 chr1:231504339 EGLN1 0.39 5.68 0.33 3.49e-8 Hemoglobin concentration; CESC cis rs11958404 0.789 rs7736318 chr5:157477593 A/G cg05962755 chr5:157440814 NA 0.62 7.23 0.41 5.17e-12 IgG glycosylation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11488864 chr4:8379238 ACOX3 0.46 6.36 0.36 8.99e-10 Fibrinogen levels; CESC cis rs710865 1.000 rs710865 chr1:19568972 A/G cg13387374 chr1:19411106 UBR4 0.54 7.06 0.4 1.43e-11 Brain structure; CESC cis rs9815354 0.812 rs17214945 chr3:41808660 A/C cg03022575 chr3:42003672 ULK4 0.7 6.34 0.36 9.96e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs1847202 0.793 rs11918132 chr3:72952144 C/T cg25664220 chr3:72788482 NA -0.39 -5.67 -0.33 3.68e-8 Motion sickness; CESC cis rs6693567 0.565 rs698921 chr1:150379517 G/A cg09579323 chr1:150459698 TARS2 0.47 5.93 0.34 9.3e-9 Migraine; CESC cis rs7914558 0.966 rs56946876 chr10:104653545 T/C cg08650961 chr10:104748594 CNNM2 0.33 5.37 0.31 1.75e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2012796 0.957 rs8009083 chr14:81818289 A/G cg02996355 chr14:81879375 NA 0.44 5.45 0.32 1.17e-7 Night sleep phenotypes; CESC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg03647317 chr4:187891568 NA -0.44 -6.78 -0.38 7.98e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs10751667 0.621 rs11246345 chr11:934924 T/C cg06064525 chr11:970664 AP2A2 -0.52 -10.37 -0.54 2.34e-21 Alzheimer's disease (late onset); CESC cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg24110177 chr3:50126178 RBM5 -0.56 -7.76 -0.43 1.85e-13 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.3.1042801R chr3:49084142 QRICH1 -0.53 -6.03 -0.35 5.55e-9 Gut microbiome composition (summer); CESC cis rs35079168 0.735 rs1887309 chr9:137308242 A/G cg13941235 chr9:137270186 RXRA 0.33 6.08 0.35 4.23e-9 Intelligence; CESC cis rs7107174 1.000 rs10899492 chr11:78109810 G/A cg02023728 chr11:77925099 USP35 0.37 5.28 0.31 2.63e-7 Testicular germ cell tumor; CESC cis rs9611565 0.546 rs739129 chr22:42118249 G/A cg06634786 chr22:41940651 POLR3H 0.66 6.64 0.38 1.73e-10 Vitiligo; CESC cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg15017067 chr4:17643749 FAM184B 0.38 5.4 0.31 1.49e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11168618 0.567 rs56354789 chr12:48803943 C/A cg24011408 chr12:48396354 COL2A1 0.36 5.61 0.33 5.17e-8 Adiponectin levels; CESC cis rs826838 0.967 rs1352123 chr12:39130992 T/C cg26384229 chr12:38710491 ALG10B -0.67 -11.03 -0.56 1.63e-23 Heart rate; CESC cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg24642844 chr7:1081250 C7orf50 -0.5 -7.05 -0.4 1.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Parkinson's disease; CESC cis rs7520050 0.778 rs3014218 chr1:46026328 A/C cg06784218 chr1:46089804 CCDC17 -0.34 -6.19 -0.36 2.25e-9 Red blood cell count;Reticulocyte count; CESC cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.19 0.3 4.29e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4771122 0.740 rs1006353 chr13:28047269 A/G cg22138327 chr13:27999177 GTF3A -0.53 -6.47 -0.37 4.83e-10 Body mass index; CESC cis rs754466 0.580 rs2289308 chr10:79579251 G/A cg17075019 chr10:79541650 NA -0.88 -13.73 -0.64 9.13e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs748404 0.516 rs523156 chr15:43811843 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.54 -6.56 -0.37 2.76e-10 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11122148 chr13:45150705 TSC22D1 0.63 7.38 0.41 2.1e-12 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg03609598 chr5:56110824 MAP3K1 -0.52 -5.44 -0.32 1.2e-7 Initial pursuit acceleration; CESC cis rs6500395 1.000 rs1486411 chr16:48587083 T/C cg04672837 chr16:48644449 N4BP1 0.49 6.23 0.36 1.83e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13232424 chr2:128849480 UGGT1 0.46 6.0 0.35 6.54e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7546094 0.935 rs3013439 chr1:113200671 T/G cg22162597 chr1:113214053 CAPZA1 -0.39 -6.01 -0.35 6.14e-9 Platelet distribution width; CESC cis rs8072100 0.713 rs2136750 chr17:45456100 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -5.46 -0.32 1.12e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg10083149 chr2:3321068 TSSC1 0.48 6.17 0.35 2.52e-9 Recombination measurement; CESC cis rs3857067 0.806 rs722486 chr4:95092315 G/A cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.04 -0.49 3.47e-17 QT interval; CESC cis rs11871801 1.000 rs12948909 chr17:40570602 A/C cg21433558 chr17:40837037 CNTNAP1 0.46 5.27 0.31 2.89e-7 Crohn's disease; CESC cis rs34330 0.562 rs10845615 chr12:12863470 C/T cg04607235 chr12:12878440 APOLD1 -0.81 -9.32 -0.5 4.71e-18 Systemic lupus erythematosus; CESC cis rs79349575 0.756 rs2291726 chr17:47039254 T/C cg16584676 chr17:46985605 UBE2Z -0.48 -5.94 -0.34 9.15e-9 Type 2 diabetes; CESC cis rs10411936 0.924 rs8110761 chr19:16501005 A/G cg10248733 chr19:16607483 C19orf44;CALR3 0.54 6.48 0.37 4.5e-10 White blood cell count;Multiple sclerosis; CESC cis rs35110281 0.720 rs162392 chr21:44941406 A/G cg21573476 chr21:45109991 RRP1B -0.42 -5.78 -0.33 2.05e-8 Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26726589 chr20:306364 SOX12 -0.43 -6.04 -0.35 5.3300000000000004e-09 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs425277 0.917 rs12410859 chr1:2038732 C/T cg04315214 chr1:2043799 PRKCZ -0.46 -6.39 -0.37 7.56e-10 Height; CESC cis rs10504229 0.906 rs2270608 chr8:58194688 T/C cg24829409 chr8:58192753 C8orf71 -0.75 -9.61 -0.51 6.02e-19 Developmental language disorder (linguistic errors); CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg24528447 chr5:92918517 NR2F1 0.46 6.67 0.38 1.51e-10 Positive affect; CESC cis rs6088590 0.965 rs13040449 chr20:33358901 T/A cg08999081 chr20:33150536 PIGU 0.61 9.23 0.49 9.02e-18 Coronary artery disease; CESC cis rs3026101 0.671 rs8077471 chr17:5299356 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.59 0.32 5.77e-8 Body mass index; CESC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg24675658 chr1:53192096 ZYG11B -0.67 -9.55 -0.51 9.18e-19 Monocyte count; CESC cis rs11690935 0.655 rs12997093 chr2:172564438 A/G cg13550731 chr2:172543902 DYNC1I2 0.56 7.81 0.43 1.32e-13 Schizophrenia; CESC cis rs2777491 0.574 rs316611 chr15:41751678 A/G cg20272979 chr15:41787780 ITPKA -0.4 -5.03 -0.3 9.12e-7 Ulcerative colitis; CESC cis rs796364 0.806 rs12619136 chr2:200910347 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC cis rs2721195 0.626 rs59464125 chr8:145857786 G/A cg11211951 chr8:145729740 GPT -0.32 -5.41 -0.32 1.41e-7 Age at first birth; CESC cis rs4253772 0.530 rs9615933 chr22:46677298 G/A cg10541313 chr22:46663664 TTC38 0.71 5.26 0.31 2.99e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg24733560 chr20:60626293 TAF4 0.46 6.91 0.39 3.52e-11 Body mass index; CESC cis rs6547741 1.000 rs4666007 chr2:27856495 T/C cg27432699 chr2:27873401 GPN1 0.46 6.43 0.37 5.87e-10 Oral cavity cancer; CESC cis rs9354308 0.966 rs1909533 chr6:66565658 G/A cg07460842 chr6:66804631 NA 0.67 7.67 0.43 3.2e-13 Metabolite levels; CESC trans rs9388451 0.626 rs3734637 chr6:126081319 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.62 -8.64 -0.47 5.41e-16 Brugada syndrome; CESC cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg03467027 chr4:99064603 C4orf37 0.43 5.44 0.32 1.24e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8040855 0.627 rs35668291 chr15:85652813 A/G cg08123816 chr15:85640762 PDE8A -0.39 -5.67 -0.33 3.75e-8 Bulimia nervosa; CESC trans rs2018683 0.624 rs2286219 chr7:28998663 G/A cg19402173 chr7:128379420 CALU -0.57 -6.97 -0.39 2.58e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs1797885 0.844 rs2655260 chr3:12563640 T/C cg26432171 chr3:12704882 RAF1 -0.48 -6.12 -0.35 3.35e-9 Immature fraction of reticulocytes; CESC cis rs1153858 0.621 rs2687512 chr15:45581495 T/C cg09092052 chr15:45571596 NA 0.45 5.11 0.3 6.31e-7 Homoarginine levels; CESC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg04553112 chr3:125709451 NA 0.53 5.82 0.34 1.66e-8 Blood pressure (smoking interaction); CESC cis rs7267979 0.740 rs2259961 chr20:25282626 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 14.56 0.67 1.07e-35 Liver enzyme levels (alkaline phosphatase); CESC cis rs7210086 0.948 rs60947290 chr17:70636944 C/A cg04206342 chr17:70636940 NA -0.31 -5.48 -0.32 9.7e-8 Ulcerative colitis; CESC cis rs1167827 0.680 rs1167796 chr7:75173180 C/T cg04978709 chr7:75101039 POM121C -0.45 -5.79 -0.34 1.96e-8 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9790314 0.586 rs11710086 chr3:161125858 A/T cg03342759 chr3:160939853 NMD3 -0.44 -5.71 -0.33 2.99e-8 Morning vs. evening chronotype; CESC cis rs7937682 1.000 rs11608149 chr11:111535102 G/A cg22437258 chr11:111473054 SIK2 -0.69 -8.24 -0.45 7.81e-15 Primary sclerosing cholangitis; CESC cis rs6424115 0.830 rs2501426 chr1:24199364 G/A cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25675393 chr21:46494274 ADARB1;C21orf122 0.58 6.7 0.38 1.23e-10 Gut microbiome composition (summer); CESC cis rs10504229 0.516 rs7821160 chr8:57986281 C/T cg22535103 chr8:58192502 C8orf71 0.48 5.94 0.34 8.74e-9 Developmental language disorder (linguistic errors); CESC cis rs7772486 0.790 rs4435956 chr6:146232403 G/C cg05347473 chr6:146136440 FBXO30 -0.55 -7.05 -0.4 1.57e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9902453 0.808 rs1986555 chr17:28014448 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.76 0.47 2.29e-16 Coffee consumption (cups per day); CESC cis rs2370759 0.945 rs74625866 chr10:32597618 A/T cg05361325 chr10:32636312 EPC1 -0.57 -5.47 -0.32 1.06e-7 Sexual dysfunction (female); CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg08968635 chr6:28129556 ZNF389 0.41 5.37 0.31 1.76e-7 Depression; CESC cis rs2841277 0.738 rs1036713 chr14:105396693 C/G cg21017887 chr14:105400489 NA -0.38 -6.22 -0.36 1.93e-9 Rheumatoid arthritis; CESC cis rs2197308 0.655 rs1971964 chr12:37870474 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.98 0.56 2.29e-23 Morning vs. evening chronotype; CESC cis rs10838687 0.673 rs4752965 chr11:47159053 G/A cg25783544 chr11:47291846 MADD 0.54 5.43 0.32 1.29e-7 Proinsulin levels; CESC cis rs7659604 0.605 rs67772833 chr4:122723106 G/A cg19748678 chr4:122722346 EXOSC9 0.61 7.77 0.43 1.75e-13 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07074586 chr12:56555325 MYL6 -0.5 -6.04 -0.35 5.13e-9 Gut microbiome composition (summer); CESC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg02896835 chr1:92012615 NA -0.53 -6.82 -0.39 6.02e-11 Breast cancer; CESC cis rs4629180 1.000 rs974374 chr2:102105846 C/T cg04415270 chr2:102091202 RFX8 0.46 7.52 0.42 8.52e-13 Chronic rhinosinusitis with nasal polyps; CESC cis rs10191773 0.589 rs72831636 chr2:112948248 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.71 -6.9 -0.39 3.9e-11 Yeast infection; CESC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC cis rs7605827 0.930 rs6431704 chr2:15592061 G/T cg19274914 chr2:15703543 NA 0.36 6.45 0.37 5.41e-10 Educational attainment (years of education); CESC cis rs9300255 0.602 rs1716160 chr12:123700225 C/T cg05973401 chr12:123451056 ABCB9 0.49 5.63 0.33 4.65e-8 Neutrophil percentage of white cells; CESC cis rs3820928 0.845 rs7570869 chr2:227878818 A/C cg05526886 chr2:227700861 RHBDD1 -0.46 -5.74 -0.33 2.61e-8 Pulmonary function; CESC cis rs4689388 0.890 rs13130845 chr4:6297646 A/C cg00701064 chr4:6280414 WFS1 0.68 11.52 0.58 3.75e-25 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24391471 chr3:44974926 ZDHHC3 0.5 6.61 0.38 2.17e-10 Fibrinogen levels; CESC cis rs36096196 0.891 rs74046969 chr1:2251348 G/A cg17974515 chr1:2252516 NA 0.45 7.53 0.42 8.2e-13 Coronary artery disease; CESC cis rs698833 0.926 rs1067370 chr2:44652343 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.87 0.34 1.3e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs11098499 0.863 rs13134665 chr4:120426430 T/C cg25214090 chr10:38739885 LOC399744 0.72 9.81 0.52 1.36e-19 Corneal astigmatism; CESC trans rs9569823 0.813 rs7324740 chr13:58696106 A/G cg09262171 chr16:4140361 ADCY9 0.36 6.07 0.35 4.31e-9 Intelligence (multi-trait analysis); CESC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg07701084 chr6:150067640 NUP43 0.45 6.27 0.36 1.42e-9 Lung cancer; CESC cis rs7927771 0.965 rs35985502 chr11:47847428 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -6.04 -0.35 5.24e-9 Subjective well-being; CESC cis rs2637266 0.505 rs17467566 chr10:78293458 C/T cg18941641 chr10:78392320 NA 0.3 5.12 0.3 5.91e-7 Pulmonary function; CESC cis rs12042938 0.600 rs823161 chr1:231775017 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.41 5.49 0.32 9.29e-8 Neuranatomic and neurocognitive phenotypes; CESC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg16132339 chr22:24313637 DDTL;DDT 0.37 5.53 0.32 7.74e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs897984 0.683 rs13337900 chr16:30822409 G/A cg02466173 chr16:30829666 NA -0.59 -11.46 -0.58 5.99e-25 Dementia with Lewy bodies; CESC cis rs9486719 0.843 rs2499793 chr6:96846402 A/C cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs17253792 0.732 rs10146604 chr14:56045770 C/G cg01858014 chr14:56050164 KTN1 -0.94 -7.66 -0.43 3.47e-13 Putamen volume; CESC cis rs1865760 0.588 rs9467658 chr6:26010881 T/G cg17691542 chr6:26056736 HIST1H1C 0.38 5.16 0.3 4.86e-7 Height; CESC cis rs9916302 0.861 rs7503514 chr17:37669884 G/C cg15445000 chr17:37608096 MED1 0.4 6.56 0.37 2.85e-10 Glomerular filtration rate (creatinine); CESC cis rs8060686 0.641 rs113704872 chr16:68032598 G/A cg26727032 chr16:67993705 SLC12A4 -0.52 -5.78 -0.33 2.09e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs7225537 0.509 rs11870035 chr17:17033397 C/T cg20098446 chr17:17120238 FLCN 0.34 5.28 0.31 2.69e-7 Mean platelet volume; CESC cis rs6974235 0.806 rs42079 chr7:95711301 A/G cg21022364 chr7:95948586 SLC25A13 0.37 5.2 0.3 3.91e-7 Total body bone mineral density; CESC cis rs11030122 0.635 rs10835540 chr11:4071429 T/A cg18678763 chr11:4115507 RRM1 -0.47 -6.26 -0.36 1.58e-9 Mean platelet volume;Platelet distribution width; CESC cis rs72781680 0.611 rs7596060 chr2:24334361 A/G cg06627628 chr2:24431161 ITSN2 0.67 6.61 0.38 2.15e-10 Lymphocyte counts; CESC cis rs10779751 0.762 rs6671083 chr1:11325910 A/G cg08854313 chr1:11322531 MTOR -0.69 -9.52 -0.5 1.14e-18 Body mass index; CESC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.08 0.4 1.27e-11 Bipolar disorder; CESC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.24 -0.36 1.77e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs2573652 0.722 rs968412 chr15:100544512 C/G cg01831454 chr5:148417172 SH3TC2 0.31 6.05 0.35 4.87e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03024183 chr8:37963317 ASH2L 0.64 7.84 0.43 1.12e-13 Gut microbiome composition (summer); CESC trans rs61931739 0.534 rs12371021 chr12:34062252 T/C cg26384229 chr12:38710491 ALG10B 0.61 8.47 0.46 1.67e-15 Morning vs. evening chronotype; CESC cis rs208520 0.526 rs4710310 chr6:66802808 T/C cg07460842 chr6:66804631 NA -1.12 -27.01 -0.86 4.56e-78 Exhaled nitric oxide output; CESC cis rs4566357 1.000 rs3769637 chr2:227922623 T/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.37 -0.31 1.68e-7 Coronary artery disease; CESC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs9486719 1.000 rs35487471 chr6:96879715 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg04362960 chr10:104952993 NT5C2 0.51 6.58 0.37 2.53e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs11719291 0.833 rs34037363 chr3:48821036 C/T cg00383909 chr3:49044727 WDR6 0.92 6.66 0.38 1.62e-10 Cognitive function; CESC cis rs7178572 0.568 rs7166927 chr15:77673459 A/G cg22256960 chr15:77711686 NA 0.53 6.89 0.39 4.01e-11 Type 2 diabetes; CESC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg24101359 chr6:42928495 GNMT 0.56 7.91 0.44 7.1e-14 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2204008 0.548 rs8189475 chr12:38037115 C/T cg26384229 chr12:38710491 ALG10B 0.57 8.23 0.45 8.76e-15 Bladder cancer; CESC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg23281280 chr6:28129359 ZNF389 0.59 8.21 0.45 9.45e-15 Depression; CESC cis rs17253792 0.822 rs28549152 chr14:56091239 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs9300255 0.544 rs1790130 chr12:123701270 A/C cg00376283 chr12:123451042 ABCB9 0.7 8.83 0.48 1.45e-16 Neutrophil percentage of white cells; CESC cis rs8114671 0.562 rs6119536 chr20:33450041 A/G cg07148914 chr20:33460835 GGT7 -0.45 -6.65 -0.38 1.72e-10 Height; CESC cis rs734999 0.545 rs6684865 chr1:2546229 A/G cg20673091 chr1:2541236 MMEL1 -0.43 -7.22 -0.41 5.54e-12 Ulcerative colitis; CESC cis rs854765 0.520 rs7219324 chr17:17909775 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.52 -7.23 -0.41 5.19e-12 Total body bone mineral density; CESC trans rs875971 0.660 rs2013222 chr7:66035936 C/G cg26939375 chr7:64535504 NA -0.64 -8.61 -0.47 6.57e-16 Aortic root size; CESC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg21854759 chr1:92012499 NA -0.42 -5.25 -0.31 3.08e-7 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04050850 chr2:219536800 STK36;RNF25 -0.49 -6.42 -0.37 6.19e-10 Ulcerative colitis; CESC cis rs36051895 0.593 rs12340379 chr9:5176352 C/T cg02405213 chr9:5042618 JAK2 -0.5 -6.46 -0.37 5.09e-10 Pediatric autoimmune diseases; CESC cis rs10751667 0.600 rs6597948 chr11:1005308 C/T cg01483505 chr11:975446 AP2A2 0.39 5.04 0.3 8.53e-7 Alzheimer's disease (late onset); CESC cis rs6500395 1.000 rs9933237 chr16:48676562 T/C cg04672837 chr16:48644449 N4BP1 0.51 6.31 0.36 1.16e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3015497 0.789 rs7147956 chr14:51142605 G/A cg09863266 chr14:51125203 SAV1 -0.34 -5.17 -0.3 4.73e-7 Mean platelet volume; CESC cis rs3762637 0.882 rs72958418 chr3:122160373 G/C cg24169773 chr3:122142474 KPNA1 -0.55 -6.59 -0.38 2.38e-10 LDL cholesterol levels; CESC trans rs66573146 0.831 rs67315413 chr4:6987910 T/C cg07817883 chr1:32538562 TMEM39B 1.14 7.98 0.44 4.51e-14 Granulocyte percentage of myeloid white cells; CESC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.64 0.33 4.45e-8 Menopause (age at onset); CESC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs7927771 0.524 rs7943213 chr11:47715524 T/C cg18512352 chr11:47633146 NA 0.36 5.46 0.32 1.09e-7 Subjective well-being; CESC cis rs1178968 0.688 rs6951676 chr7:72753243 C/T cg25889504 chr7:72793014 NA 0.47 5.03 0.3 8.91e-7 Triglyceride levels; CESC cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg13877915 chr19:58951672 ZNF132 0.39 5.79 0.34 1.98e-8 Uric acid clearance; CESC cis rs9467711 0.606 rs9379857 chr6:26367654 G/C cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs12973672 0.812 rs35497966 chr19:35764965 A/C cg12095397 chr19:35769544 USF2 0.52 6.58 0.37 2.53e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1538970 0.961 rs884962 chr1:45847981 G/A cg03146154 chr1:46216737 IPP 0.46 5.53 0.32 7.61e-8 Platelet count; CESC cis rs6089584 0.507 rs6061999 chr20:60637429 G/A cg06108461 chr20:60628389 TAF4 -0.57 -7.56 -0.42 6.49e-13 Body mass index; CESC cis rs2243480 1.000 rs937108 chr7:65428452 G/A cg18252515 chr7:66147081 NA -1.08 -10.42 -0.54 1.55e-21 Diabetic kidney disease; CESC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.84 10.25 0.53 5.72e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg00815214 chr21:47717953 NA -0.46 -6.42 -0.37 6.39e-10 Testicular germ cell tumor; CESC cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg07697082 chr8:82753677 SNX16 0.36 5.54 0.32 7.16e-8 Diastolic blood pressure; CESC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg21963583 chr11:68658836 MRPL21 0.4 5.52 0.32 8.06e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9815354 0.812 rs114034165 chr3:41823297 G/A cg03022575 chr3:42003672 ULK4 0.7 6.2 0.36 2.11e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6121246 0.567 rs6058187 chr20:30190923 T/C cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs9818941 0.955 rs4362677 chr3:157667357 A/G cg08654915 chr3:157813417 NA 0.46 7.95 0.44 5.45e-14 Height; CESC trans rs1814175 0.645 rs10128563 chr11:50023681 T/C cg15704280 chr7:45808275 SEPT13 -1.0 -18.54 -0.75 9.01e-50 Height; CESC cis rs9811920 0.638 rs7629426 chr3:99652577 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.57 -7.02 -0.4 1.84e-11 Axial length; CESC cis rs2050392 0.630 rs303428 chr10:30739058 C/T cg18806716 chr10:30721971 MAP3K8 0.42 6.05 0.35 5.03e-9 Inflammatory bowel disease; CESC cis rs4803468 0.967 rs11083619 chr19:41913267 A/C cg14132834 chr19:41945861 ATP5SL -0.67 -8.31 -0.45 5.08e-15 Height; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg17804498 chr8:23167318 LOXL2 0.45 6.4 0.37 6.91e-10 Recombination measurement; CESC cis rs727505 0.819 rs4142718 chr7:124731688 T/A cg23710748 chr7:124431027 NA -0.4 -6.52 -0.37 3.56e-10 Lewy body disease; CESC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg26318627 chr11:63887540 MACROD1 0.36 5.44 0.32 1.24e-7 Platelet count; CESC cis rs4253772 0.530 rs6008662 chr22:46713917 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.79 9.3 0.5 5.26e-18 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16361266 chr1:1313144 NA 0.5 6.02 0.35 5.92e-9 Gut microbiome composition (summer); CESC cis rs932287 0.536 rs10840160 chr11:9053536 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.44 -7.01 -0.4 1.92e-11 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.3e-7 Colonoscopy-negative controls vs population controls; CESC cis rs727505 0.564 rs4731236 chr7:124827236 G/T cg23710748 chr7:124431027 NA -0.33 -5.04 -0.3 8.75e-7 Lewy body disease; CESC trans rs1814175 0.817 rs12295885 chr11:50036762 T/G cg03929089 chr4:120376271 NA -0.94 -15.92 -0.7 1.64e-40 Height; CESC cis rs3791556 0.853 rs35245395 chr2:240107661 C/T cg03281426 chr2:240109471 HDAC4 0.54 6.95 0.39 2.81e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs6912958 1.000 rs9450701 chr6:88173167 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -5.79 -0.34 2e-8 Monocyte percentage of white cells; CESC cis rs8040855 0.657 rs6496733 chr15:85673176 G/T cg08123816 chr15:85640762 PDE8A 0.36 5.28 0.31 2.68e-7 Bulimia nervosa; CESC cis rs2200578 1.000 rs116648076 chr2:99882347 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.49 5.32 0.31 2.21e-7 IgG glycosylation; CESC cis rs77741769 0.591 rs73413868 chr12:121301732 T/C cg02419362 chr12:121203948 SPPL3 0.34 5.59 0.32 5.6e-8 Mean corpuscular volume; CESC cis rs4919694 0.572 rs12240508 chr10:104939232 G/A cg04362960 chr10:104952993 NT5C2 0.64 6.44 0.37 5.66e-10 Arsenic metabolism; CESC cis rs3820928 0.839 rs13404750 chr2:227876129 G/A cg05526886 chr2:227700861 RHBDD1 -0.42 -5.16 -0.3 4.96e-7 Pulmonary function; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg14821842 chr8:118532860 MED30 -0.48 -6.16 -0.35 2.66e-9 Thyroid stimulating hormone; CESC cis rs12541635 0.966 rs10955409 chr8:107022586 A/C cg10147462 chr8:107024639 NA 0.43 6.42 0.37 6.16e-10 Age of smoking initiation; CESC cis rs7914558 0.966 rs943035 chr10:104839152 T/C cg15744005 chr10:104629667 AS3MT -0.32 -5.04 -0.3 8.72e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs847577 0.609 rs6977321 chr7:97774859 A/G cg24562669 chr7:97807699 LMTK2 0.83 13.76 0.65 7.37e-33 Breast cancer; CESC cis rs6788895 1.000 rs74950732 chr3:150482621 C/T cg07663535 chr3:150480033 SIAH2 0.72 5.09 0.3 6.94e-7 Breast cancer; CESC trans rs875971 1.000 rs1540651 chr7:65650121 C/T cg26939375 chr7:64535504 NA -0.48 -6.37 -0.36 8.2e-10 Aortic root size; CESC cis rs208520 0.690 rs12213928 chr6:66762978 G/A cg07460842 chr6:66804631 NA 0.96 13.05 0.63 2.22e-30 Exhaled nitric oxide output; CESC cis rs950169 0.922 rs11639244 chr15:84832650 G/A cg17507749 chr15:85114479 UBE2QP1 0.55 6.25 0.36 1.66e-9 Schizophrenia; CESC cis rs7044106 0.734 rs1981020 chr9:123388464 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.8 12.55 0.61 1.17e-28 Hip circumference adjusted for BMI; CESC cis rs9911578 1.000 rs7223955 chr17:56917053 C/A cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis); CESC cis rs4561483 0.583 rs9925010 chr16:11956668 A/G cg08843971 chr16:11963173 GSPT1 0.46 6.42 0.37 6.1e-10 Testicular germ cell tumor; CESC cis rs35110281 0.626 rs162368 chr21:44934767 G/A cg21573476 chr21:45109991 RRP1B -0.36 -5.16 -0.3 4.88e-7 Mean corpuscular volume; CESC cis rs10504229 0.636 rs77691549 chr8:58055126 G/T cg02725872 chr8:58115012 NA -0.41 -5.94 -0.34 8.93e-9 Developmental language disorder (linguistic errors); CESC cis rs763014 0.898 rs916414 chr16:632073 C/T cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg03467027 chr4:99064603 C4orf37 0.43 5.42 0.32 1.34e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.775 rs10021601 chr4:120282563 G/A cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs1784581 0.588 rs9295178 chr6:162419226 T/A cg17173639 chr6:162384350 PARK2 0.56 8.62 0.47 6.34e-16 Itch intensity from mosquito bite; CESC cis rs8092503 1.000 rs12457761 chr18:52476870 T/A cg12377874 chr18:52495404 RAB27B 0.39 6.16 0.35 2.63e-9 Childhood body mass index; CESC cis rs863345 0.967 rs10399681 chr1:158525551 C/T cg12129480 chr1:158549410 OR10X1 -0.31 -6.42 -0.37 6.27e-10 Pneumococcal bacteremia; CESC cis rs9863 0.828 rs4765541 chr12:124465995 T/C cg17562584 chr12:124393655 DNAH10 0.32 5.51 0.32 8.62e-8 White blood cell count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17498856 chr1:1457042 ATAD3A 0.44 6.12 0.35 3.36e-9 Fibrinogen levels; CESC cis rs11122272 0.706 rs2749710 chr1:231535112 A/C cg06096015 chr1:231504339 EGLN1 -0.42 -6.02 -0.35 5.79e-9 Hemoglobin concentration; CESC cis rs1218582 0.682 rs12046459 chr1:154912017 A/C cg03351412 chr1:154909251 PMVK 0.69 9.08 0.49 2.5e-17 Prostate cancer; CESC cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.35 5.74 0.33 2.57e-8 Monocyte percentage of white cells; CESC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg22535103 chr8:58192502 C8orf71 -0.92 -10.22 -0.53 6.79e-21 Developmental language disorder (linguistic errors); CESC cis rs6831352 0.918 rs17218162 chr4:100056060 G/A cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs11098499 0.775 rs2002049 chr4:120257417 A/G cg09307838 chr4:120376055 NA 0.8 10.89 0.56 4.43e-23 Corneal astigmatism; CESC cis rs9457247 1.000 rs405553 chr6:167395058 A/G cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC cis rs10089 0.953 rs1012851 chr5:127360241 T/C cg19767477 chr5:127420684 SLC12A2 -0.39 -5.11 -0.3 6.08e-7 Ileal carcinoids; CESC cis rs2439831 1.000 rs690002 chr15:43729349 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.6 0.55 4.2e-22 Lung cancer in ever smokers; CESC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg11764359 chr7:65958608 NA -0.77 -10.96 -0.56 2.75e-23 Aortic root size; CESC cis rs965469 1.000 rs6037547 chr20:3299228 C/A cg25506879 chr20:3388711 C20orf194 -0.56 -6.08 -0.35 4.16e-9 IFN-related cytopenia; CESC cis rs910316 0.737 rs91144 chr14:75449517 G/A cg08847533 chr14:75593920 NEK9 -0.89 -15.08 -0.68 1.65e-37 Height; CESC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg00129232 chr17:37814104 STARD3 0.57 7.28 0.41 3.91e-12 Glomerular filtration rate (creatinine); CESC trans rs4349753 0.663 rs7718290 chr5:144075908 A/C cg22407458 chr6:35109121 TCP11 0.5 6.29 0.36 1.31e-9 Photic sneeze reflex; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02930078 chr6:17706856 NUP153 -0.45 -6.08 -0.35 4.07e-9 Fibrinogen levels; CESC cis rs3540 0.533 rs11633692 chr15:91056043 G/A cg10434728 chr15:90938212 IQGAP1 -0.4 -6.97 -0.39 2.51e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg26874164 chr19:58962979 ZNF324B 0.8 11.95 0.59 1.29e-26 Mean platelet volume; CESC cis rs7917772 0.582 rs10883736 chr10:104320029 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 5.76 0.33 2.35e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs35146811 0.622 rs6946204 chr7:99589125 T/C cg22906224 chr7:99728672 NA 0.43 5.18 0.3 4.42e-7 Coronary artery disease; CESC cis rs7582720 1.000 rs72934510 chr2:203925360 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.84 7.25 0.41 4.63e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs28498503 1.000 rs9964465 chr18:76662714 A/G cg00806245 chr18:76673096 NA 0.63 5.61 0.33 5.2e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs11608355 0.521 rs7978210 chr12:109835990 A/G cg19025524 chr12:109796872 NA -0.52 -7.25 -0.41 4.67e-12 Neuroticism; CESC cis rs523522 0.923 rs10774553 chr12:120954984 T/C cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC trans rs3213758 0.588 rs12931642 chr16:53599637 G/A cg22729726 chr1:3123854 PRDM16 -0.5 -6.1 -0.35 3.68e-9 Vitiligo (non-segmental); CESC cis rs6942756 0.876 rs6953598 chr7:129033741 A/G cg02491457 chr7:128862824 NA 0.58 8.1 0.45 2.08e-14 White matter hyperintensity burden; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24117104 chr4:149366997 NA -0.6 -7.34 -0.41 2.55e-12 Gut microbiome composition (summer); CESC cis rs11750568 0.904 rs1826864 chr5:178509565 C/T cg10208897 chr5:178548229 ADAMTS2 0.37 5.23 0.31 3.5e-7 Height; CESC trans rs2727020 0.658 rs7111215 chr11:49430552 T/C cg03929089 chr4:120376271 NA -0.8 -12.5 -0.61 1.64e-28 Coronary artery disease; CESC cis rs4595586 0.525 rs10506132 chr12:39404599 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.51 0.32 8.48e-8 Morning vs. evening chronotype; CESC cis rs6088590 0.523 rs6058084 chr20:33183804 C/T cg24642439 chr20:33292090 TP53INP2 0.63 8.4 0.46 2.65e-15 Coronary artery disease; CESC cis rs35306767 0.951 rs55742421 chr10:961037 A/C cg10556349 chr10:835070 NA 0.66 6.32 0.36 1.08e-9 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16119628 chr10:88282035 WAPAL 0.57 7.02 0.4 1.85e-11 Gut microbiome composition (summer); CESC cis rs873946 0.586 rs12767391 chr10:134573844 A/G cg26818010 chr10:134567672 INPP5A 0.85 10.48 0.54 9.91e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg00255919 chr5:131827918 IRF1 0.51 8.68 0.47 4.19e-16 Asthma (sex interaction); CESC cis rs8067545 0.586 rs3850779 chr17:20171872 C/T cg13482628 chr17:19912719 NA -0.42 -5.62 -0.33 4.93e-8 Schizophrenia; CESC cis rs72781680 0.652 rs72794281 chr2:23893265 G/A cg20701182 chr2:24300061 SF3B14 0.81 7.11 0.4 1.11e-11 Lymphocyte counts; CESC cis rs76878669 0.561 rs7105015 chr11:66159390 A/G cg18002602 chr11:66138449 SLC29A2 0.43 6.95 0.39 2.79e-11 Educational attainment (years of education); CESC cis rs2279817 1.000 rs35148872 chr1:18020184 G/A cg21791023 chr1:18019539 ARHGEF10L -0.63 -8.69 -0.47 3.73e-16 Neuroticism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03751324 chr16:4029315 ADCY9 0.47 6.38 0.36 7.79e-10 Fibrinogen levels; CESC cis rs698833 0.886 rs17580226 chr2:44570776 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.56 6.99 0.39 2.27e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1559088 1.000 rs1559087 chr19:33551041 A/G cg17764715 chr19:33622953 WDR88 0.45 5.62 0.33 4.72e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2777491 1.000 rs7177641 chr15:41743426 C/T cg18705301 chr15:41695430 NDUFAF1 -0.58 -8.41 -0.46 2.5e-15 Ulcerative colitis; CESC cis rs854765 0.964 rs854764 chr17:18011750 A/G cg04398451 chr17:18023971 MYO15A 0.6 7.65 0.43 3.8e-13 Total body bone mineral density; CESC cis rs9488822 0.636 rs1544155 chr6:116346394 C/A cg26893134 chr6:116381904 FRK 0.25 6.1 0.35 3.71e-9 Cholesterol, total;LDL cholesterol; CESC cis rs7904368 0.806 rs7900527 chr10:16857992 C/G cg14835575 chr10:16859367 RSU1 0.5 5.19 0.3 4.17e-7 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs1799949 0.930 rs34210004 chr17:41370337 A/T cg23758822 chr17:41437982 NA 1.01 17.08 0.72 1.29e-44 Menopause (age at onset); CESC cis rs854765 0.618 rs9908017 chr17:17774422 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.54 -7.79 -0.43 1.51e-13 Total body bone mineral density; CESC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg12311346 chr5:56204834 C5orf35 0.63 8.71 0.47 3.31e-16 Initial pursuit acceleration; CESC cis rs3820068 0.705 rs4646109 chr1:15817319 T/C cg18192808 chr1:15853278 DNAJC16 0.44 5.37 0.31 1.71e-7 Systolic blood pressure; CESC trans rs61931739 0.500 rs11053235 chr12:34507899 G/A cg13010199 chr12:38710504 ALG10B 0.5 6.42 0.37 6.3e-10 Morning vs. evening chronotype; CESC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg01448562 chr3:133502909 NA -0.42 -5.74 -0.33 2.63e-8 Iron status biomarkers; CESC cis rs72781680 0.593 rs72797817 chr2:24350569 A/G cg20701182 chr2:24300061 SF3B14 0.9 10.37 0.54 2.26e-21 Lymphocyte counts; CESC cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg02487422 chr3:49467188 NICN1 -0.39 -5.11 -0.3 6.16e-7 Parkinson's disease; CESC cis rs17039065 0.920 rs7695026 chr4:109436476 G/A cg16022748 chr4:109541635 LOC285456;RPL34 0.67 6.4 0.37 7.14e-10 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg25427524 chr10:38739819 LOC399744 -0.67 -9.69 -0.51 3.27e-19 Extrinsic epigenetic age acceleration; CESC cis rs9905704 0.846 rs2567894 chr17:56794115 G/A cg12560992 chr17:57184187 TRIM37 0.62 7.78 0.43 1.6e-13 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26987855 chr6:10426637 NA -0.6 -6.37 -0.36 8.29e-10 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg06873352 chr17:61820015 STRADA 0.47 6.85 0.39 5.19e-11 Height; CESC cis rs796364 0.760 rs2881594 chr2:201026183 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.78 -6.71 -0.38 1.2e-10 Schizophrenia; CESC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg11764359 chr7:65958608 NA -0.73 -10.48 -0.54 1.01e-21 Aortic root size; CESC cis rs9660992 0.674 rs17345837 chr1:205263122 C/T cg21643547 chr1:205240462 TMCC2 -0.44 -5.81 -0.34 1.83e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg00684032 chr4:1343700 KIAA1530 0.39 5.43 0.32 1.27e-7 Obesity-related traits; CESC cis rs7552404 0.545 rs12748741 chr1:76351193 A/G cg03433033 chr1:76189801 ACADM -0.55 -5.68 -0.33 3.49e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs77972916 0.505 rs11899984 chr2:43578246 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -6.62 -0.38 1.98e-10 Granulocyte percentage of myeloid white cells; CESC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg22800045 chr5:56110881 MAP3K1 0.77 9.43 0.5 2.14e-18 Initial pursuit acceleration; CESC cis rs6062302 0.522 rs11696202 chr20:62246292 G/C cg09650180 chr20:62225654 GMEB2 -0.82 -9.38 -0.5 3.04e-18 Glioblastoma; CESC cis rs763014 0.838 rs4984670 chr16:641044 A/G cg00908189 chr16:619842 PIGQ 0.64 8.51 0.46 1.28e-15 Height; CESC cis rs2404602 0.692 rs58889902 chr15:77173070 A/C cg22467129 chr15:76604101 ETFA -0.35 -5.27 -0.31 2.8e-7 Blood metabolite levels; CESC cis rs7845219 0.544 rs34208552 chr8:95908067 C/G cg23172400 chr8:95962367 TP53INP1 -0.39 -7.21 -0.41 5.68e-12 Type 2 diabetes; CESC cis rs10463316 0.817 rs58892766 chr5:150776115 T/C cg03212797 chr5:150827313 SLC36A1 -0.42 -5.3 -0.31 2.49e-7 Metabolite levels (Pyroglutamine); CESC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg27535305 chr1:53392650 SCP2 0.31 5.56 0.32 6.61e-8 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27381194 chr2:96932018 CIAO1;TMEM127 0.57 6.79 0.38 7.45e-11 Gut microbiome composition (summer); CESC cis rs250677 0.687 rs168750 chr5:148446756 A/G cg18129178 chr5:148520854 ABLIM3 -0.51 -5.83 -0.34 1.58e-8 Breast cancer; CESC cis rs34638657 0.732 rs11866711 chr16:82201038 A/C cg09439754 chr16:82129088 HSD17B2 -0.36 -6.24 -0.36 1.71e-9 Lung adenocarcinoma; CESC trans rs3942852 0.806 rs1875696 chr11:48133526 G/A cg03929089 chr4:120376271 NA -0.56 -6.28 -0.36 1.38e-9 Acute lymphoblastic leukemia (childhood); CESC trans rs877282 0.853 rs11253332 chr10:755262 G/C cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg08888203 chr3:10149979 C3orf24 0.46 6.01 0.35 6.24e-9 Alzheimer's disease; CESC cis rs17445774 0.503 rs17531061 chr2:201113452 G/T cg23649088 chr2:200775458 C2orf69 -0.57 -5.37 -0.31 1.68e-7 LDL cholesterol to HDL cholesterol ratio; CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg03395511 chr6:291903 DUSP22 -0.71 -8.91 -0.48 8.28e-17 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17243582 chr15:59969081 BNIP2 -0.63 -6.71 -0.38 1.18e-10 Gut microbiome composition (summer); CESC cis rs10129255 1.000 rs4612959 chr14:107175298 A/G cg07958169 chr14:107095056 NA -0.39 -5.31 -0.31 2.31e-7 Kawasaki disease; CESC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg19926776 chr19:18682709 UBA52 -0.47 -6.45 -0.37 5.38e-10 Tuberculosis; CESC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg10800226 chr5:1850261 NA 0.34 5.69 0.33 3.33e-8 Cardiovascular disease risk factors; CESC cis rs4919044 0.866 rs2478233 chr10:94778903 G/A cg16508068 chr10:94451736 HHEX -0.47 -5.13 -0.3 5.65e-7 Coronary artery disease; CESC cis rs2979489 0.891 rs2915624 chr8:30381245 T/C cg26383811 chr8:30366931 RBPMS -0.79 -9.7 -0.51 3.17e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs1775715 0.513 rs2808089 chr10:32145112 A/T cg18675610 chr10:32216311 ARHGAP12 0.34 5.4 0.31 1.47e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs3741578 0.702 rs1813812 chr12:57333395 A/G cg14720773 chr17:17603531 RAI1 0.48 6.46 0.37 4.9e-10 Asthma; CESC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg26839252 chr6:160211577 TCP1;MRPL18 0.49 6.15 0.35 2.83e-9 Age-related macular degeneration (geographic atrophy); CESC cis rs116095464 0.558 rs10068203 chr5:206618 C/T cg16372103 chr5:203701 NA 0.49 5.29 0.31 2.6e-7 Breast cancer; CESC cis rs3741151 0.686 rs12277924 chr11:73219678 T/C cg17517138 chr11:73019481 ARHGEF17 0.57 5.07 0.3 7.46e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs2953174 1.000 rs1133353 chr2:241522267 A/T cg07929629 chr2:241523174 NA -0.54 -5.46 -0.32 1.09e-7 Bipolar disorder; CESC cis rs8180040 0.966 rs9683177 chr3:47490493 G/A cg27129171 chr3:47204927 SETD2 0.62 9.25 0.49 7.87e-18 Colorectal cancer; CESC cis rs561341 0.941 rs550213 chr17:30317518 C/G cg19193384 chr17:30244184 NA -0.61 -6.45 -0.37 5.21e-10 Hip circumference adjusted for BMI; CESC cis rs11785400 0.793 rs2976400 chr8:143743611 G/A cg10596483 chr8:143751796 JRK 0.4 5.06 0.3 7.75e-7 Schizophrenia; CESC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg07308232 chr7:1071921 C7orf50 -0.42 -5.69 -0.33 3.39e-8 Longevity;Endometriosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08943809 chr16:58059531 MMP15 0.44 6.15 0.35 2.92e-9 Gut microbiota (bacterial taxa); CESC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg05368731 chr17:41323189 NBR1 0.8 11.32 0.57 1.66e-24 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26392439 chr4:87927884 AFF1 -0.59 -6.18 -0.35 2.46e-9 Gut microbiome composition (summer); CESC trans rs12310956 0.532 rs11494810 chr12:33952881 C/A cg26384229 chr12:38710491 ALG10B 0.49 6.79 0.38 7.36e-11 Morning vs. evening chronotype; CESC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg00149659 chr3:10157352 C3orf10 0.7 8.31 0.45 5.08e-15 Alzheimer's disease; CESC cis rs796364 0.806 rs79897806 chr2:201073968 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.77 -6.53 -0.37 3.37e-10 Schizophrenia; CESC cis rs7089973 0.604 rs10885618 chr10:116617718 A/G cg23260525 chr10:116636907 FAM160B1 0.42 8.12 0.45 1.8e-14 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11098499 0.820 rs28535956 chr4:120536858 C/T cg25214090 chr10:38739885 LOC399744 -0.65 -8.93 -0.48 7.19e-17 Corneal astigmatism; CESC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg06634786 chr22:41940651 POLR3H 0.7 7.03 0.4 1.8e-11 Cannabis dependence symptom count; CESC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg18876405 chr7:65276391 NA -0.58 -7.81 -0.43 1.32e-13 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25266327 chr19:16435660 KLF2 0.57 6.67 0.38 1.49e-10 Gut microbiome composition (summer); CESC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg18904891 chr8:8559673 CLDN23 0.72 8.37 0.46 3.27e-15 Obesity-related traits; CESC trans rs9467711 0.606 rs9393711 chr6:26370659 C/T cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -8.99 -0.48 4.84e-17 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.13 0.3 5.61e-7 Bipolar disorder; CESC cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg06766960 chr11:133703094 NA -0.39 -5.46 -0.32 1.08e-7 Childhood ear infection; CESC cis rs4589502 0.502 rs2169460 chr15:67197240 A/G cg18595228 chr15:67193261 NA -0.49 -6.36 -0.36 8.93e-10 Lung cancer (smoking interaction); CESC cis rs6912958 0.967 rs9450688 chr6:88159276 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.16 -0.3 4.87e-7 Monocyte percentage of white cells; CESC cis rs6686643 0.762 rs61800372 chr1:165611981 T/C cg19407955 chr1:165599744 MGST3 -0.54 -5.68 -0.33 3.55e-8 Total ventricular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26203055 chr18:19284713 ABHD3 -0.38 -6.14 -0.35 2.94e-9 Gambling; CESC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg18230493 chr5:56204884 C5orf35 -0.59 -5.77 -0.33 2.26e-8 Type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12609600 chr11:1595974 HCCA2;LOC338651 0.42 6.14 0.35 3.04e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7605827 0.897 rs10929371 chr2:15662299 A/G cg19274914 chr2:15703543 NA 0.37 6.67 0.38 1.47e-10 Educational attainment (years of education); CESC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg18876405 chr7:65276391 NA 0.59 7.78 0.43 1.64e-13 Aortic root size; CESC cis rs2243480 1.000 rs55895244 chr7:65387678 C/G cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg13114125 chr14:105738426 BRF1 -0.76 -9.36 -0.5 3.57e-18 Mean platelet volume;Platelet distribution width; CESC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.77 0.33 2.16e-8 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22423294 chr13:114286133 TFDP1 0.47 6.72 0.38 1.1e-10 Fibrinogen levels; CESC cis rs4906332 1.000 rs3783398 chr14:103949378 C/T cg09975044 chr14:104007538 NA -0.47 -6.44 -0.37 5.55e-10 Coronary artery disease; CESC cis rs965469 1.000 rs6051718 chr20:3270370 C/T cg25506879 chr20:3388711 C20orf194 -0.59 -6.24 -0.36 1.7e-9 IFN-related cytopenia; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg05657792 chr17:6899758 ALOX12 0.4 7.06 0.4 1.45e-11 Tonsillectomy; CESC cis rs5753618 0.555 rs9609304 chr22:31897795 T/C cg02404636 chr22:31891804 SFI1 0.42 5.7 0.33 3.25e-8 Colorectal cancer; CESC cis rs6120849 0.707 rs6088703 chr20:33676049 T/A cg24642439 chr20:33292090 TP53INP2 0.67 6.58 0.37 2.48e-10 Protein C levels; CESC cis rs9287719 0.967 rs7563816 chr2:10763400 C/T cg00105475 chr2:10696890 NA 0.38 5.37 0.31 1.7e-7 Prostate cancer; CESC cis rs3091242 0.933 rs35148262 chr1:25766623 A/G cg02931644 chr1:25747376 RHCE 0.47 8.06 0.44 2.6e-14 Erythrocyte sedimentation rate; CESC cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg08109568 chr15:31115862 NA 0.75 10.2 0.53 7.73e-21 Huntington's disease progression; CESC cis rs7044106 0.648 rs2031369 chr9:123360294 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.74 10.84 0.55 6.79e-23 Hip circumference adjusted for BMI; CESC cis rs17253792 0.822 rs117050012 chr14:56038729 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.73 0.33 2.76e-8 Putamen volume; CESC cis rs2439831 0.702 rs28699233 chr15:44122866 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.68 6.65 0.38 1.64e-10 Lung cancer in ever smokers; CESC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg10018233 chr7:150070692 REPIN1 0.4 5.61 0.33 4.99e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs9488822 0.636 rs7745074 chr6:116347432 G/A cg18764771 chr6:116381957 FRK 0.22 5.44 0.32 1.23e-7 Cholesterol, total;LDL cholesterol; CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg07677032 chr17:61819896 STRADA -0.52 -7.25 -0.41 4.71e-12 Prudent dietary pattern; CESC cis rs10823500 0.777 rs10762348 chr10:71952322 C/A cg02100629 chr10:71892760 AIFM2 -0.32 -5.12 -0.3 5.77e-7 Blood protein levels; CESC cis rs13385 0.813 rs12187444 chr5:139664820 T/C cg26211634 chr5:139558579 C5orf32 0.48 5.09 0.3 6.88e-7 Atrial fibrillation; CESC cis rs858239 0.539 rs6976957 chr7:23187333 T/A cg23682824 chr7:23144976 KLHL7 0.49 6.43 0.37 6.08e-10 Cerebrospinal fluid biomarker levels; CESC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg07677032 chr17:61819896 STRADA 0.45 5.99 0.35 6.8e-9 Prudent dietary pattern; CESC cis rs7845219 0.544 rs7017487 chr8:95922752 A/G cg09323728 chr8:95962352 TP53INP1 0.34 6.82 0.39 6.3e-11 Type 2 diabetes; CESC trans rs7824557 0.564 rs2572386 chr8:11236975 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -6.16 -0.35 2.7e-9 Retinal vascular caliber; CESC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg18758796 chr5:131593413 PDLIM4 -0.42 -5.65 -0.33 4.19e-8 Blood metabolite levels; CESC cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg24308560 chr3:49941425 MST1R 0.61 8.83 0.48 1.47e-16 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27656398 chr12:123451108 ABCB9 -0.48 -6.49 -0.37 4.22e-10 Fibrinogen levels; CESC cis rs2637266 0.967 rs4608018 chr10:78376110 T/C cg18941641 chr10:78392320 NA 0.43 8.24 0.45 8.17e-15 Pulmonary function; CESC cis rs3020736 0.500 rs8143153 chr22:42515637 G/C cg12850546 chr22:42539477 CYP2D7P1 0.43 5.14 0.3 5.37e-7 Autism spectrum disorder or schizophrenia; CESC cis rs5758511 0.689 rs5758691 chr22:42668504 G/C cg00645731 chr22:42541494 CYP2D7P1 0.58 8.66 0.47 4.81e-16 Birth weight; CESC cis rs4975616 0.869 rs421284 chr5:1325590 T/C cg06550200 chr5:1325588 CLPTM1L -0.71 -11.3 -0.57 2.07e-24 Lung cancer; CESC cis rs1879734 0.681 rs12076192 chr1:54157742 A/G cg23596471 chr1:54105337 GLIS1 0.34 5.41 0.32 1.42e-7 Mitral valve prolapse; CESC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg07870213 chr5:140052090 DND1 0.63 6.68 0.38 1.39e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11577318 0.853 rs4450008 chr1:26643860 C/A cg00852783 chr1:26633632 UBXN11 0.51 7.21 0.4 5.9e-12 Granulocyte percentage of myeloid white cells; CESC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg24675658 chr1:53192096 ZYG11B -0.66 -8.7 -0.47 3.67e-16 Monocyte count; CESC cis rs17807624 1.000 rs17807624 chr8:11463015 A/G cg00262122 chr8:11665843 FDFT1 -0.39 -5.11 -0.3 6.09e-7 Systemic lupus erythematosus; CESC cis rs9640161 0.789 rs28432021 chr7:150046235 G/C cg10018233 chr7:150070692 REPIN1 0.36 5.21 0.3 3.76e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17535283 chr2:26541115 GPR113 -0.4 -6.38 -0.36 8.07e-10 Gambling; CESC cis rs9905704 0.647 rs11079367 chr17:57009024 A/G cg12560992 chr17:57184187 TRIM37 0.62 7.8 0.43 1.47e-13 Testicular germ cell tumor; CESC cis rs1478897 0.898 rs2249040 chr8:11390779 A/T cg09528494 chr8:11338675 NA -0.3 -5.44 -0.32 1.22e-7 Systemic lupus erythematosus; CESC cis rs4727027 0.901 rs4727017 chr7:148822062 A/G cg23583168 chr7:148888333 NA -0.79 -12.21 -0.6 1.63e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs1814175 0.534 rs1983448 chr11:49933856 C/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.18 -0.35 2.4e-9 Height; CESC trans rs853679 0.546 rs35016036 chr6:28314880 C/T cg06606381 chr12:133084897 FBRSL1 -1.11 -8.84 -0.48 1.35e-16 Depression; CESC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg03264133 chr6:25882463 NA -0.65 -9.56 -0.51 8.82e-19 Intelligence (multi-trait analysis); CESC trans rs12518099 0.874 rs56052030 chr5:89564170 A/G cg26280695 chr10:106072440 ITPRIP -0.47 -6.02 -0.35 5.65e-9 Type 2 diabetes and other traits; CESC cis rs10504229 0.516 rs11781671 chr8:57992733 T/C cg24829409 chr8:58192753 C8orf71 -0.36 -5.11 -0.3 6.21e-7 Developmental language disorder (linguistic errors); CESC cis rs2629540 0.765 rs12221075 chr10:126534855 G/A cg08799069 chr10:126477246 METTL10 -0.53 -7.42 -0.41 1.63e-12 Cocaine dependence; CESC cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.94e-9 Extrinsic epigenetic age acceleration; CESC cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg03433033 chr1:76189801 ACADM 0.62 6.78 0.38 7.6e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10088262 0.629 rs7833650 chr8:124822969 C/T cg15047889 chr8:124780837 FAM91A1 -0.5 -6.14 -0.35 2.92e-9 Pancreatic cancer; CESC cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs12477438 0.748 rs4851185 chr2:99666497 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs7932354 0.528 rs12796744 chr11:47132724 A/T cg25783544 chr11:47291846 MADD 0.43 5.71 0.33 3.02e-8 Bone mineral density (hip);Bone mineral density; CESC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.25 -0.31 3.12e-7 Lung cancer; CESC cis rs1707322 1.000 rs1707337 chr1:46508769 A/G cg05343316 chr1:45956843 TESK2 -0.44 -5.44 -0.32 1.2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4648845 0.777 rs2477689 chr1:2395538 G/C cg02275930 chr1:2372054 NA -0.46 -7.53 -0.42 8.23e-13 Schizophrenia; CESC cis rs7635838 0.827 rs4273358 chr3:11415160 T/G cg00170343 chr3:11313890 ATG7 0.43 5.72 0.33 2.89e-8 HDL cholesterol; CESC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg24829409 chr8:58192753 C8orf71 -0.66 -7.3 -0.41 3.3e-12 Developmental language disorder (linguistic errors); CESC cis rs6088580 0.634 rs6120644 chr20:33023810 G/A cg24642439 chr20:33292090 TP53INP2 0.52 6.79 0.39 7.18e-11 Glomerular filtration rate (creatinine); CESC cis rs8135665 0.625 rs8142185 chr22:38451080 A/C cg13116946 chr22:38479732 SLC16A8 0.42 5.2 0.3 4.03e-7 Advanced age-related macular degeneration;Age-related macular degeneration; CESC cis rs9640161 0.742 rs2108852 chr7:150019628 T/C cg10018233 chr7:150070692 REPIN1 0.46 7.29 0.41 3.59e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs6121246 0.559 rs6119728 chr20:30413121 G/A cg13852791 chr20:30311386 BCL2L1 0.83 10.64 0.55 2.92e-22 Mean corpuscular hemoglobin; CESC cis rs6762 0.748 rs7928935 chr11:839127 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.67 -8.76 -0.47 2.4e-16 Mean platelet volume; CESC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg03188948 chr7:1209495 NA 0.71 6.99 0.39 2.17e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs3749237 0.964 rs1799845 chr3:49847623 A/G cg21659725 chr3:3221576 CRBN 0.51 6.13 0.35 3.21e-9 Resting heart rate; CESC cis rs829883 0.664 rs1096148 chr12:98851005 A/G cg25150519 chr12:98850993 NA 0.87 14.77 0.67 2.01e-36 Colorectal adenoma (advanced); CESC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.68 -7.72 -0.43 2.4e-13 Gut microbiome composition (summer); CESC cis rs6460942 0.597 rs6961238 chr7:12535428 C/T cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg17376030 chr22:41985996 PMM1 -0.79 -8.32 -0.46 4.67e-15 Vitiligo; CESC cis rs9914544 0.966 rs9915346 chr17:18787931 G/A cg26378065 chr17:18585709 ZNF286B 0.46 5.62 0.33 4.89e-8 Educational attainment (years of education); CESC cis rs7647973 1.000 rs11710434 chr3:49346130 T/C cg07636037 chr3:49044803 WDR6 0.67 9.54 0.51 9.63e-19 Menarche (age at onset); CESC cis rs9682041 0.660 rs13089256 chr3:170113601 G/A cg11886554 chr3:170076028 SKIL 0.7 6.46 0.37 4.94e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs933688 1.000 rs985434 chr5:90744509 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 13.7 0.64 1.17e-32 Smoking behavior; CESC cis rs11031096 0.683 rs55898672 chr11:4189284 G/C cg18678763 chr11:4115507 RRM1 -0.4 -5.18 -0.3 4.46e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs12579753 0.917 rs12372724 chr12:82193628 C/T cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg08859206 chr1:53392774 SCP2 0.54 7.15 0.4 8.22e-12 Monocyte count; CESC cis rs2046867 0.818 rs17010188 chr3:72870351 T/C cg25664220 chr3:72788482 NA -0.45 -6.54 -0.37 3.08e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs2625529 0.652 rs28650442 chr15:72155445 A/T cg16672083 chr15:72433130 SENP8 -0.47 -7.03 -0.4 1.75e-11 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07151637 chr22:32149913 DEPDC5 0.6 6.86 0.39 4.93e-11 Gut microbiome composition (summer); CESC trans rs11098499 0.954 rs2389803 chr4:120393511 A/G cg25214090 chr10:38739885 LOC399744 -0.68 -9.67 -0.51 3.85e-19 Corneal astigmatism; CESC cis rs2710247 1 rs2710247 chr2:219467508 A/G cg02176678 chr2:219576539 TTLL4 0.4 6.72 0.38 1.1e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9486715 1.000 rs11153082 chr6:97059666 A/G cg18709589 chr6:96969512 KIAA0776 -0.46 -6.4 -0.37 6.94e-10 Headache; CESC cis rs11750568 0.967 rs931619 chr5:178514729 C/T cg10208897 chr5:178548229 ADAMTS2 -0.38 -5.36 -0.31 1.8e-7 Height; CESC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg17724175 chr1:150552817 MCL1 0.44 7.23 0.41 5.25e-12 Tonsillectomy; CESC cis rs6540556 0.723 rs12138452 chr1:209886578 T/A cg05527609 chr1:210001259 C1orf107 -0.7 -7.5 -0.42 9.83e-13 Red blood cell count; CESC cis rs78456975 0.527 rs10203194 chr2:1558021 A/G cg12573674 chr2:1569213 NA -0.45 -5.29 -0.31 2.57e-7 Placebo response in major depressive disorder (% change in symptom score); CESC trans rs61931739 0.517 rs7960878 chr12:34055645 C/A cg26384229 chr12:38710491 ALG10B 0.6 8.36 0.46 3.68e-15 Morning vs. evening chronotype; CESC cis rs72945132 0.882 rs55905028 chr11:70127750 G/A cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs208515 0.518 rs12209790 chr6:66662965 T/C cg07460842 chr6:66804631 NA 0.83 10.33 0.54 3.09e-21 Exhaled nitric oxide levels; CESC cis rs7267979 1.000 rs6083856 chr20:25407585 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.42 -0.71 2.87e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs941207 0.507 rs7297289 chr12:57076487 T/C cg05584118 chr12:57595605 LRP1 -0.37 -5.04 -0.3 8.53e-7 Platelet count; CESC cis rs9815354 0.812 rs73071341 chr3:41826211 C/T cg03022575 chr3:42003672 ULK4 0.71 6.2 0.36 2.11e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7208859 0.524 rs73263982 chr17:28920624 T/C cg04154034 chr17:28927549 LRRC37B2 0.67 6.02 0.35 5.73e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs5167 0.504 rs7248162 chr19:45454686 T/C cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.51e-10 Blood protein levels; CESC cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg02551604 chr5:131831745 NA -0.37 -5.27 -0.31 2.81e-7 Asthma (sex interaction); CESC cis rs7666738 0.830 rs1527517 chr4:98931907 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs4664304 0.816 rs67045814 chr2:160821119 A/C cg03641300 chr2:160917029 PLA2R1 -0.41 -5.59 -0.33 5.5e-8 Crohn's disease;Inflammatory bowel disease; CESC trans rs13360092 1.000 rs78895441 chr5:50563723 C/G cg03200537 chr16:87022121 NA 0.69 6.01 0.35 6.15e-9 Verbal declarative memory; CESC cis rs4727027 0.901 rs1534198 chr7:148772323 T/C cg23583168 chr7:148888333 NA -0.78 -11.78 -0.59 4.8e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2742417 0.603 rs2064062 chr3:45761115 G/C cg04837898 chr3:45731254 SACM1L -0.47 -6.21 -0.36 2.08e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs9910055 0.529 rs425038 chr17:42182028 T/C cg08499158 chr17:42289980 UBTF 0.42 5.07 0.3 7.61e-7 Total body bone mineral density; CESC cis rs17253792 0.822 rs78826571 chr14:56048906 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.85 5.74 0.33 2.53e-8 Putamen volume; CESC cis rs7296418 0.663 rs4553407 chr12:123750748 G/C cg00376283 chr12:123451042 ABCB9 0.61 8.4 0.46 2.77e-15 Platelet count; CESC cis rs7927771 0.524 rs2869024 chr11:47674101 G/A cg20307385 chr11:47447363 PSMC3 -0.62 -8.64 -0.47 5.55e-16 Subjective well-being; CESC trans rs11039571 0.588 rs61917001 chr11:48233667 G/C cg15704280 chr7:45808275 SEPT13 0.72 7.16 0.4 7.74e-12 D-dimer levels; CESC cis rs2066819 1.000 rs17118409 chr12:56630764 G/A cg26714650 chr12:56694279 CS -1.42 -10.04 -0.53 2.52e-20 Psoriasis vulgaris; CESC cis rs6690583 0.623 rs6679539 chr1:85479457 G/T cg22153463 chr1:85462885 MCOLN2 -0.77 -7.73 -0.43 2.29e-13 Serum sulfate level; CESC cis rs10779751 0.959 rs2092642 chr1:11317320 C/T cg08854313 chr1:11322531 MTOR 0.91 14.45 0.66 2.77e-35 Body mass index; CESC cis rs9929218 0.906 rs34565494 chr16:68741769 C/T cg02972257 chr16:68554789 NA 0.57 6.36 0.36 8.78e-10 Colorectal cancer; CESC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.6 -8.16 -0.45 1.38e-14 Personality dimensions; CESC cis rs6785206 0.892 rs6439143 chr3:128425132 C/T cg16766828 chr3:128327626 NA -0.53 -5.28 -0.31 2.66e-7 Lymphocyte percentage of white cells; CESC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg24829409 chr8:58192753 C8orf71 -0.65 -7.42 -0.41 1.6e-12 Developmental language disorder (linguistic errors); CESC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg11764359 chr7:65958608 NA -0.78 -10.74 -0.55 1.44e-22 Aortic root size; CESC cis rs1878931 0.696 rs35984213 chr16:3451030 G/A cg22508957 chr16:3507546 NAT15 -0.44 -6.47 -0.37 4.72e-10 Body mass index (adult); CESC cis rs1559088 0.545 rs7257431 chr19:33566924 A/G cg17764715 chr19:33622953 WDR88 0.6 8.48 0.46 1.6e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9362426 0.708 rs7744793 chr6:88102040 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.52 6.09 0.35 3.86e-9 Depressive episodes in bipolar disorder; CESC cis rs11690935 0.959 rs10194102 chr2:172626143 G/C cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.95 -0.68 4.66e-37 Schizophrenia; CESC cis rs6693567 0.565 rs1260374 chr1:150331593 G/A cg09579323 chr1:150459698 TARS2 0.49 6.22 0.36 1.92e-9 Migraine; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09847284 chr11:45907071 MAPK8IP1 0.49 6.26 0.36 1.55e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs72781680 0.560 rs111310684 chr2:24265682 C/G cg20701182 chr2:24300061 SF3B14 0.94 10.66 0.55 2.67e-22 Lymphocyte counts; CESC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.13 0.81 3.58e-62 Prudent dietary pattern; CESC cis rs11676348 0.791 rs6726126 chr2:218952233 G/A cg00012203 chr2:219082015 ARPC2 -0.53 -6.96 -0.39 2.64e-11 Ulcerative colitis; CESC cis rs10791097 0.547 rs12365680 chr11:130749059 C/T cg12179176 chr11:130786555 SNX19 0.69 10.8 0.55 8.78e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7592578 0.599 rs62180992 chr2:191285732 A/G cg27211696 chr2:191398769 TMEM194B -0.61 -5.93 -0.34 9.44e-9 Diastolic blood pressure; CESC cis rs11718455 0.920 rs4682927 chr3:44033299 C/A cg08738300 chr3:44038990 NA 0.45 6.1 0.35 3.68e-9 Coronary artery disease; CESC trans rs1728785 1.000 rs1170439 chr16:68608511 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 7.89 0.44 7.95e-14 Ulcerative colitis; CESC cis rs6938 0.618 rs12912839 chr15:75221245 C/T cg17294928 chr15:75287854 SCAMP5 0.5 6.48 0.37 4.49e-10 Breast cancer; CESC cis rs11785400 1.000 rs4557682 chr8:143738182 T/C cg10596483 chr8:143751796 JRK 0.43 5.65 0.33 4.1e-8 Schizophrenia; CESC cis rs79149102 0.649 rs1531163 chr15:75113083 A/G cg09165964 chr15:75287851 SCAMP5 -0.78 -6.1 -0.35 3.79e-9 Lung cancer; CESC cis rs7267979 0.586 rs1473695 chr20:25186965 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.66 10.94 0.56 3.16e-23 Liver enzyme levels (alkaline phosphatase); CESC cis rs2425143 1.000 rs57963833 chr20:34344225 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -7.89 -0.44 8.21e-14 Blood protein levels; CESC cis rs710216 0.917 rs4660691 chr1:43417150 T/G cg22176566 chr1:43424700 SLC2A1 -0.51 -5.68 -0.33 3.46e-8 Red cell distribution width; CESC cis rs7017914 0.967 rs6993115 chr8:71699183 G/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.3 -0.31 2.38e-7 Bone mineral density; CESC cis rs1707322 0.721 rs11211178 chr1:46227566 G/T cg06784218 chr1:46089804 CCDC17 0.41 7.22 0.41 5.64e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs642858 0.822 rs2050717 chr6:140369781 C/T cg27524944 chr6:140295369 NA -0.34 -5.07 -0.3 7.32e-7 Type 2 diabetes; CESC cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.77 8.79 0.48 1.96e-16 Alzheimer's disease; CESC cis rs1670533 0.872 rs13108222 chr4:1054256 C/A cg04106633 chr4:1044584 NA 0.41 5.2 0.3 4.01e-7 Recombination rate (females); CESC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg18402987 chr7:1209562 NA 0.78 7.99 0.44 4.1e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3768617 0.811 rs10911205 chr1:183009277 C/A ch.1.3577855R chr1:183094577 LAMC1 0.65 8.89 0.48 9.94e-17 Fuchs's corneal dystrophy; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg06484986 chr15:42841099 LRRC57;HAUS2 0.43 6.01 0.35 6.05e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4919087 0.748 rs701814 chr10:98975719 C/T cg25902810 chr10:99078978 FRAT1 -0.45 -5.22 -0.31 3.57e-7 Monocyte count; CESC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg15813090 chr5:442598 EXOC3;C5orf55 0.39 5.79 0.34 1.95e-8 Cystic fibrosis severity; CESC cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg25019033 chr10:957182 NA -0.61 -6.33 -0.36 1.02e-9 Eosinophil percentage of granulocytes; CESC cis rs6967385 0.704 rs17149929 chr7:12406080 A/T cg20607287 chr7:12443886 VWDE 0.34 5.57 0.32 6.15e-8 Response to taxane treatment (placlitaxel); CESC cis rs963731 0.649 rs2924710 chr2:39302757 G/C cg04010122 chr2:39346883 SOS1 -0.76 -5.75 -0.33 2.4e-8 Corticobasal degeneration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02838608 chr17:47438799 ZNF652 -0.54 -6.61 -0.38 2.16e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17095167 chr13:21833918 NA 0.5 7.03 0.4 1.72e-11 Fibrinogen levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg08638312 chr10:12171805 SEC61A2 -0.54 -6.92 -0.39 3.38e-11 Asthma; CESC trans rs6952808 0.823 rs58222895 chr7:1885064 G/A cg24247370 chr13:99142703 STK24 -0.41 -6.15 -0.35 2.78e-9 Bipolar disorder and schizophrenia; CESC trans rs208520 1.000 rs72882102 chr6:66983408 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.33 0.5 4.5e-18 Exhaled nitric oxide output; CESC cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg03213289 chr20:61660250 NA 0.39 6.16 0.35 2.7e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg23708337 chr7:1209742 NA 0.49 5.3 0.31 2.46e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12477438 0.798 rs13414153 chr2:99624748 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -9.2 -0.49 1.14e-17 Chronic sinus infection; CESC cis rs9611565 0.592 rs57102627 chr22:41987627 T/C cg17376030 chr22:41985996 PMM1 0.49 5.49 0.32 9.33e-8 Vitiligo; CESC cis rs13108904 0.870 rs4974578 chr4:1266072 A/G cg00684032 chr4:1343700 KIAA1530 0.42 5.96 0.34 7.99e-9 Obesity-related traits; CESC cis rs79349575 0.783 rs12453394 chr17:46994970 G/A cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs2070433 0.706 rs55696586 chr21:47733918 T/C cg12379764 chr21:47803548 PCNT 0.6 6.32 0.36 1.1e-9 Lymphocyte counts; CESC cis rs7829975 0.714 rs6994038 chr8:8660538 C/A cg06636001 chr8:8085503 FLJ10661 0.48 6.19 0.36 2.27e-9 Mood instability; CESC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.2 -0.36 2.21e-9 Parkinson's disease; CESC cis rs2439831 0.850 rs28524541 chr15:44124831 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.46 0.42 1.22e-12 Lung cancer in ever smokers; CESC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg11890956 chr21:40555474 PSMG1 -0.63 -8.81 -0.48 1.69e-16 Menarche (age at onset); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg01825986 chr20:47804552 STAU1 -0.44 -6.16 -0.35 2.62e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7953508 0.506 rs3869308 chr12:93959918 A/G cg18151635 chr12:93972918 NA -0.47 -6.44 -0.37 5.54e-10 Pubertal anthropometrics; CESC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg08968635 chr6:28129556 ZNF389 0.42 5.72 0.33 2.82e-8 Depression; CESC cis rs8067545 0.611 rs2703805 chr17:20107773 T/C cg13482628 chr17:19912719 NA -0.44 -5.95 -0.34 8.25e-9 Schizophrenia; CESC cis rs7122539 0.646 rs682842 chr11:66568943 A/G cg24851651 chr11:66362959 CCS -0.49 -7.17 -0.4 7.45e-12 HIV-1 susceptibility; CESC cis rs2073300 1.000 rs6137959 chr20:23442640 T/C cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4563143 0.675 rs17498203 chr19:29279734 G/T cg12667521 chr19:29218732 NA 0.48 6.19 0.36 2.22e-9 Methadone dose in opioid dependence; CESC cis rs1568889 0.877 rs7933326 chr11:28288416 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.83 0.55 7.18e-23 Bipolar disorder; CESC cis rs2932538 0.922 rs6690169 chr1:113114974 A/G cg22162597 chr1:113214053 CAPZA1 0.55 6.96 0.39 2.59e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs941873 0.805 rs876678 chr10:81111036 G/T cg09469691 chr10:81107165 PPIF 0.51 6.91 0.39 3.52e-11 Height; CESC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg18305652 chr10:134549665 INPP5A 0.46 6.32 0.36 1.13e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg02592271 chr2:27665507 KRTCAP3 -0.3 -5.97 -0.34 7.49e-9 Total body bone mineral density; CESC cis rs6964587 0.839 rs9656002 chr7:91475007 A/G cg17063962 chr7:91808500 NA -0.48 -6.21 -0.36 2.07e-9 Breast cancer; CESC cis rs3806843 0.966 rs1030166 chr5:140185473 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.33 -0.31 2.08e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg19500275 chr17:80737654 TBCD 0.49 5.59 0.32 5.75e-8 Glycated hemoglobin levels; CESC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 12.99 0.62 3.48e-30 Platelet count; CESC cis rs7959452 0.535 rs10878953 chr12:69674187 A/G cg20891283 chr12:69753455 YEATS4 0.72 10.26 0.53 5.19e-21 Blood protein levels; CESC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg07685180 chr8:600429 NA -0.66 -5.08 -0.3 6.97e-7 IgG glycosylation; CESC cis rs9488822 0.676 rs868943 chr6:116337503 G/A cg18764771 chr6:116381957 FRK 0.22 5.44 0.32 1.23e-7 Cholesterol, total;LDL cholesterol; CESC cis rs9457247 0.602 rs13204839 chr6:167471119 G/A cg07741184 chr6:167504864 NA 0.38 6.7 0.38 1.22e-10 Crohn's disease; CESC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg03188948 chr7:1209495 NA 0.69 6.56 0.37 2.74e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7605827 0.866 rs34815739 chr2:15533375 A/G cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs7095944 0.614 rs7898003 chr10:126451385 G/A cg08799069 chr10:126477246 METTL10 -0.35 -5.15 -0.3 5.19e-7 Asthma; CESC cis rs9828933 0.752 rs28675788 chr3:63942188 C/G cg16258503 chr3:63850278 ATXN7;THOC7 -0.95 -8.42 -0.46 2.43e-15 Type 2 diabetes; CESC cis rs17376456 0.877 rs12109629 chr5:93359702 A/G cg25358565 chr5:93447407 FAM172A 1.1 10.93 0.56 3.31e-23 Diabetic retinopathy; CESC cis rs2072499 0.966 rs1137703 chr1:156184458 T/C cg25208724 chr1:156163844 SLC25A44 0.99 17.9 0.74 1.68e-47 Testicular germ cell tumor; CESC cis rs3106136 0.967 rs2171381 chr4:95224768 T/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.53 -0.37 3.34e-10 Capecitabine sensitivity; CESC cis rs6547741 0.904 rs2384628 chr2:27774702 T/G cg27432699 chr2:27873401 GPN1 0.47 6.62 0.38 1.95e-10 Oral cavity cancer; CESC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg08109568 chr15:31115862 NA 0.73 9.9 0.52 7.4e-20 Huntington's disease progression; CESC cis rs10744422 0.925 rs3825143 chr12:123352179 C/T cg25930673 chr12:123319894 HIP1R -0.67 -5.29 -0.31 2.54e-7 Schizophrenia; CESC cis rs6456156 0.586 rs12527827 chr6:167469271 C/T cg07741184 chr6:167504864 NA 0.36 6.17 0.35 2.48e-9 Primary biliary cholangitis; CESC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg22535103 chr8:58192502 C8orf71 -1.03 -12.78 -0.62 1.84e-29 Developmental language disorder (linguistic errors); CESC cis rs9914988 0.673 rs9890212 chr17:27169890 G/C cg20469991 chr17:27169893 C17orf63 -0.51 -5.76 -0.33 2.32e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.33 -5.95 -0.34 8.25e-9 Bipolar disorder; CESC cis rs796364 0.806 rs76112266 chr2:201087157 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.77 -6.66 -0.38 1.59e-10 Schizophrenia; CESC cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg00825309 chr19:58991885 ZNF446 -0.54 -7.55 -0.42 7.07e-13 Uric acid clearance; CESC cis rs6964587 1.000 rs35317449 chr7:91637010 G/A cg17063962 chr7:91808500 NA 0.57 7.93 0.44 6.22e-14 Breast cancer; CESC cis rs28489187 0.617 rs233061 chr1:85799282 G/A cg16011679 chr1:85725395 C1orf52 0.46 5.52 0.32 7.91e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg03396347 chr1:1875803 NA -0.43 -6.69 -0.38 1.33e-10 Body mass index; CESC cis rs4631830 0.869 rs11006207 chr10:51538176 T/C cg16070123 chr10:51489643 NA -0.34 -5.07 -0.3 7.4e-7 Prostate-specific antigen levels; CESC cis rs9309473 0.950 rs7596773 chr2:73846000 C/T cg20560298 chr2:73613845 ALMS1 -0.51 -6.54 -0.37 3.17e-10 Metabolite levels; CESC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg00149659 chr3:10157352 C3orf10 0.73 8.97 0.48 5.62e-17 Alzheimer's disease; CESC cis rs17376456 1.000 rs34756085 chr5:93556294 A/G cg21475434 chr5:93447410 FAM172A 0.89 7.34 0.41 2.62e-12 Diabetic retinopathy; CESC cis rs12682352 0.579 rs7006589 chr8:8668486 A/G cg17143192 chr8:8559678 CLDN23 0.43 5.07 0.3 7.61e-7 Neuroticism; CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg07308232 chr7:1071921 C7orf50 -0.41 -5.5 -0.32 9.14e-8 Longevity;Endometriosis; CESC trans rs10776614 0.799 rs7350424 chr10:49765730 C/A cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg06634786 chr22:41940651 POLR3H 0.68 6.78 0.38 7.6e-11 Vitiligo; CESC cis rs11098499 1.000 rs13116504 chr4:120209412 A/C cg09307838 chr4:120376055 NA 0.88 11.9 0.59 1.87e-26 Corneal astigmatism; CESC cis rs9393777 0.588 rs6941920 chr6:26492149 C/T cg12826209 chr6:26865740 GUSBL1 0.59 6.91 0.39 3.52e-11 Intelligence (multi-trait analysis); CESC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.81 -0.34 1.76e-8 Parkinson's disease; CESC cis rs7084402 0.935 rs4141671 chr10:60338753 T/C cg07615347 chr10:60278583 BICC1 -0.56 -8.48 -0.46 1.63e-15 Refractive error; CESC cis rs2191566 0.576 rs395803 chr19:44494694 A/G cg20607764 chr19:44506953 ZNF230 0.45 5.7 0.33 3.16e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs12476592 0.602 rs1867849 chr2:63726932 C/T cg17519650 chr2:63277830 OTX1 -0.47 -5.4 -0.31 1.46e-7 Childhood ear infection; CESC cis rs2737618 0.651 rs2816975 chr1:200081159 A/G cg21825944 chr1:200113062 NR5A2 -0.43 -6.85 -0.39 5.28e-11 Uric acid levels; CESC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg05332525 chr7:65337924 VKORC1L1 -0.45 -5.74 -0.33 2.61e-8 Calcium levels; CESC cis rs2522056 1.000 rs2106854 chr5:131769174 C/T cg24060327 chr5:131705240 SLC22A5 0.65 7.5 0.42 9.49e-13 Lymphocyte counts;Fibrinogen; CESC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.84 0.62 1.12e-29 Alzheimer's disease; CESC cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg11657440 chr19:46296263 DMWD -0.59 -7.24 -0.41 4.98e-12 Coronary artery disease; CESC cis rs1707322 0.963 rs11211202 chr1:46292382 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.5 0.32 8.73e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg01579765 chr21:45077557 HSF2BP -0.56 -9.24 -0.49 8.15e-18 Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13725913 chr9:140675929 EHMT1 0.45 6.46 0.37 4.87e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2361718 0.568 rs1042397 chr17:78092063 G/A cg21238619 chr17:78079768 GAA -0.38 -6.16 -0.35 2.73e-9 Yeast infection; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.7.2254086F chr7:105135578 PUS7 0.46 6.43 0.37 6.07e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg00684032 chr4:1343700 KIAA1530 0.39 5.43 0.32 1.27e-7 Obesity-related traits; CESC cis rs56046484 0.956 rs17540501 chr15:85638101 C/G cg08123816 chr15:85640762 PDE8A -0.5 -6.02 -0.35 5.77e-9 Testicular germ cell tumor; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg10315922 chr12:66563928 TMBIM4 -0.4 -6.37 -0.36 8.18e-10 Vertical cup-disc ratio; CESC cis rs3747547 0.642 rs35690683 chr9:38076664 C/T cg13774184 chr9:37916125 SHB -0.66 -5.62 -0.33 4.82e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs9322193 0.884 rs11155679 chr6:150080017 T/C cg02462569 chr6:150064036 NUP43 -0.38 -5.42 -0.32 1.32e-7 Lung cancer; CESC cis rs26868 0.766 rs27556 chr16:2249325 T/C cg07587117 chr16:2239488 CASKIN1 0.33 5.34 0.31 2.02e-7 Height; CESC cis rs7786877 0.521 rs2293767 chr7:100361675 A/G cg20848291 chr7:100343083 ZAN 0.5 6.18 0.36 2.35e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs854765 0.663 rs4925120 chr17:17754633 C/T cg16928487 chr17:17741425 SREBF1 0.61 11.39 0.57 9.98e-25 Total body bone mineral density; CESC cis rs7945705 0.870 rs10840142 chr11:8906078 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.51 8.08 0.44 2.3e-14 Hemoglobin concentration; CESC cis rs8067354 0.574 rs1292043 chr17:57934169 A/G cg13753209 chr17:57696993 CLTC 0.57 6.09 0.35 3.89e-9 Hemoglobin concentration; CESC cis rs12477438 0.520 rs6542866 chr2:99764592 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.89 0.62 7.96e-30 Chronic sinus infection; CESC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg18876405 chr7:65276391 NA -0.5 -6.54 -0.37 3.16e-10 Aortic root size; CESC cis rs4237845 0.537 rs2002275 chr12:58283385 A/G cg00677455 chr12:58241039 CTDSP2 0.7 9.54 0.51 9.85e-19 Intelligence (multi-trait analysis); CESC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg09699651 chr6:150184138 LRP11 0.4 5.08 0.3 7.24e-7 Lung cancer; CESC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg10896456 chr17:42255109 ASB16;C17orf65 0.46 6.83 0.39 5.87e-11 Total body bone mineral density; CESC trans rs7947523 0.813 rs4999940 chr11:80942337 C/T cg26035463 chr12:117627651 FBXO21 0.48 6.2 0.36 2.15e-9 Emphysema imaging phenotypes; CESC cis rs6831352 0.918 rs17217949 chr4:100054312 A/G cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs11264213 0.591 rs399393 chr1:36553673 A/G cg27506609 chr1:36549197 TEKT2 -0.75 -7.15 -0.4 8.51e-12 Schizophrenia; CESC cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg05347473 chr6:146136440 FBXO30 0.56 7.07 0.4 1.37e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09938328 chr1:39325620 RRAGC 0.5 6.43 0.37 5.9e-10 Gut microbiome composition (summer); CESC cis rs6831352 0.918 rs2602895 chr4:100045840 C/T cg13256891 chr4:100009986 ADH5 0.74 8.13 0.45 1.63e-14 Alcohol dependence; CESC cis rs7772486 0.840 rs2814867 chr6:146334030 C/A cg23711669 chr6:146136114 FBXO30 0.82 11.9 0.59 1.96e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs11711311 1.000 rs34475696 chr3:113458293 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.27 0.53 4.81e-21 IgG glycosylation; CESC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.13 21.71 0.8 9.48e-61 Prudent dietary pattern; CESC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg18876405 chr7:65276391 NA 0.54 7.18 0.4 7.22e-12 Aortic root size; CESC cis rs72781680 0.752 rs55859418 chr2:23904231 C/A cg20701182 chr2:24300061 SF3B14 0.81 6.94 0.39 3.05e-11 Lymphocyte counts; CESC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg05234568 chr11:5960015 NA -0.61 -7.29 -0.41 3.68e-12 DNA methylation (variation); CESC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg11764359 chr7:65958608 NA -0.78 -11.17 -0.57 5.37e-24 Aortic root size; CESC cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg21214613 chr1:16344536 HSPB7 0.37 5.28 0.31 2.69e-7 Dilated cardiomyopathy; CESC cis rs9768139 0.733 rs71545585 chr7:158118672 G/A cg06219351 chr7:158114137 PTPRN2 -0.48 -7.29 -0.41 3.58e-12 Calcium levels; CESC cis rs9300255 0.510 rs1790109 chr12:123637752 C/G cg00376283 chr12:123451042 ABCB9 0.7 8.88 0.48 1.03e-16 Neutrophil percentage of white cells; CESC cis rs7584330 0.744 rs10929234 chr2:238380034 C/G cg14458575 chr2:238380390 NA -0.88 -12.58 -0.61 9.33e-29 Prostate cancer; CESC cis rs72781680 0.821 rs111571980 chr2:24201695 C/G cg08917208 chr2:24149416 ATAD2B 0.64 6.22 0.36 1.92e-9 Lymphocyte counts; CESC cis rs1670533 1.000 rs12645644 chr4:1054159 C/T cg27284194 chr4:1044797 NA 0.41 5.23 0.31 3.37e-7 Recombination rate (females); CESC cis rs7017914 0.967 rs13257800 chr8:71714133 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.44 -5.71 -0.33 2.97e-8 Bone mineral density; CESC cis rs1059312 0.966 rs35907548 chr12:129282180 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -10.09 -0.53 1.81e-20 Systemic lupus erythematosus; CESC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg24733560 chr20:60626293 TAF4 0.44 6.28 0.36 1.37e-9 Body mass index; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg17446216 chr1:32480239 KHDRBS1 -0.45 -6.46 -0.37 4.94e-10 Asthma; CESC cis rs2637266 0.626 rs846619 chr10:78545449 A/G cg18941641 chr10:78392320 NA 0.41 7.71 0.43 2.48e-13 Pulmonary function; CESC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg24675658 chr1:53192096 ZYG11B -0.6 -7.73 -0.43 2.23e-13 Monocyte count; CESC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg27170947 chr2:26402098 FAM59B -0.76 -9.71 -0.51 2.95e-19 Gut microbiome composition (summer); CESC cis rs9640161 0.789 rs34728606 chr7:150054694 G/A cg10018233 chr7:150070692 REPIN1 0.4 5.72 0.33 2.86e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs6504340 0.793 rs56128659 chr17:46621828 T/A cg04904318 chr17:46607828 HOXB1 -0.56 -5.21 -0.3 3.76e-7 Primary tooth development (number of teeth); CESC cis rs919433 0.889 rs12693816 chr2:198208420 T/A cg10820045 chr2:198174542 NA -0.41 -5.98 -0.34 7.31e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9303401 0.614 rs34920953 chr17:56589406 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.53 0.61 1.36e-28 Cognitive test performance; CESC cis rs6977955 1.000 rs6977955 chr7:28156887 A/G cg23620719 chr7:28220237 JAZF1 -0.47 -5.43 -0.32 1.28e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg23161317 chr6:28129485 ZNF389 0.5 6.22 0.36 1.89e-9 Depression; CESC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.46 5.67 0.33 3.73e-8 Tuberculosis; CESC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg18876405 chr7:65276391 NA -0.49 -6.75 -0.38 9.38e-11 Aortic root size; CESC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg08888203 chr3:10149979 C3orf24 0.47 6.07 0.35 4.31e-9 Alzheimer's disease; CESC cis rs4523957 0.855 rs216212 chr17:2134214 T/C cg16513277 chr17:2031491 SMG6 0.63 8.84 0.48 1.36e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs13392177 0.660 rs10932762 chr2:219076213 G/C cg00012203 chr2:219082015 ARPC2 -0.66 -8.25 -0.45 7.36e-15 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs7927771 0.524 rs7107792 chr11:47669249 A/C cg18512352 chr11:47633146 NA 0.34 5.34 0.31 2.01e-7 Subjective well-being; CESC cis rs4819052 0.679 rs2255761 chr21:46683622 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 9.48 0.5 1.49e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg24675658 chr1:53192096 ZYG11B 0.64 7.96 0.44 5.13e-14 Monocyte count; CESC cis rs807669 0.772 rs809901 chr22:19228736 C/T cg02655711 chr22:19163373 SLC25A1 0.54 7.96 0.44 5.14e-14 Metabolite levels; CESC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg18230493 chr5:56204884 C5orf35 -0.62 -8.17 -0.45 1.27e-14 Initial pursuit acceleration; CESC trans rs1814175 0.645 rs28436748 chr11:50046422 G/A cg03929089 chr4:120376271 NA -0.91 -14.82 -0.67 1.29e-36 Height; CESC cis rs2644899 0.793 rs2644916 chr19:41309211 A/G cg24958765 chr19:41283667 RAB4B -0.55 -5.93 -0.34 9.25e-9 Post bronchodilator FEV1/FVC ratio; CESC cis rs7828089 0.582 rs7825938 chr8:22266866 G/A cg13512537 chr8:22265999 SLC39A14 -0.36 -5.13 -0.3 5.71e-7 Verbal declarative memory; CESC cis rs73206853 0.686 rs7139314 chr12:110923871 G/A cg12870014 chr12:110450643 ANKRD13A 0.65 5.59 0.32 5.78e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2380220 0.938 rs6923253 chr6:95970141 C/G cg15832292 chr6:96025679 MANEA 0.66 6.13 0.35 3.09e-9 Behavioural disinhibition (generation interaction); CESC cis rs9399135 0.967 rs4451151 chr6:135310546 C/T cg24558204 chr6:135376177 HBS1L 0.51 6.92 0.39 3.31e-11 Red blood cell count; CESC cis rs6565180 0.888 rs12447833 chr16:30390314 T/C cg17640201 chr16:30407289 ZNF48 0.94 13.64 0.64 1.91e-32 Tonsillectomy; CESC cis rs131805 1.000 rs3091397 chr22:50957520 C/T cg25309564 chr22:51001381 C22orf41 0.59 6.72 0.38 1.13e-10 Granulocyte percentage of myeloid white cells; CESC cis rs11190604 1.000 rs4919465 chr10:102221703 C/T cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg20607287 chr7:12443886 VWDE 0.76 10.98 0.56 2.3e-23 Coronary artery disease; CESC cis rs2985684 0.948 rs6572592 chr14:50080871 G/A cg02151108 chr14:50098012 C14orf104 -0.41 -5.43 -0.32 1.26e-7 Carotid intima media thickness; CESC cis rs117623576 0.680 rs11008756 chr10:32363137 A/G cg03047570 chr10:32398778 NA -0.61 -6.61 -0.38 2.17e-10 Anti-saccade response; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27572068 chr3:25728371 NA -0.58 -6.88 -0.39 4.43e-11 Gut microbiome composition (summer); CESC cis rs10733682 0.659 rs13287548 chr9:129466456 C/T cg00232160 chr9:129468157 NA 0.38 6.07 0.35 4.51e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1023500 0.573 rs2413666 chr22:42459622 C/T cg04733989 chr22:42467013 NAGA 0.78 11.69 0.58 9.73e-26 Schizophrenia; CESC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs427691 0.625 rs845738 chr5:109018115 G/A cg00054525 chr16:88717587 CYBA -0.61 -6.64 -0.38 1.73e-10 Autism spectrum disorder or schizophrenia; CESC cis rs4253772 0.591 rs6008365 chr22:46652929 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.68 8.12 0.45 1.8e-14 LDL cholesterol;Cholesterol, total; CESC cis rs12477438 0.520 rs6741772 chr2:99738961 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.15 0.68 9.04e-38 Chronic sinus infection; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17343483 chr2:97527523 SEMA4C -0.52 -7.04 -0.4 1.66e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3020736 0.500 rs6002597 chr22:42488160 C/A cg12850546 chr22:42539477 CYP2D7P1 0.44 5.23 0.31 3.44e-7 Autism spectrum disorder or schizophrenia; CESC trans rs9391997 0.567 rs4256472 chr6:434915 A/G cg18341491 chr13:38174258 POSTN 0.31 6.1 0.35 3.66e-9 Chronic lymphocytic leukemia; CESC cis rs7917772 0.503 rs7899576 chr10:104307504 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.65 0.43 3.63e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9549367 0.789 rs9549701 chr13:113881752 G/C cg00898013 chr13:113819073 PROZ -0.5 -6.85 -0.39 5.21e-11 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05102554 chr3:38388371 XYLB 0.65 7.4 0.41 1.76e-12 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.53 -0.37 3.29e-10 Bipolar disorder; CESC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg17724175 chr1:150552817 MCL1 0.45 7.39 0.41 1.88e-12 Tonsillectomy; CESC cis rs3733585 0.699 rs7657340 chr4:9966772 A/T cg11266682 chr4:10021025 SLC2A9 -0.58 -10.94 -0.56 3.08e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4561483 0.583 rs11075027 chr16:11948895 T/C cg08843971 chr16:11963173 GSPT1 0.48 6.64 0.38 1.78e-10 Testicular germ cell tumor; CESC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg12963246 chr6:28129442 ZNF389 0.54 7.12 0.4 1.02e-11 Parkinson's disease; CESC cis rs2295499 0.754 rs2285082 chr4:2627698 G/A cg27239842 chr4:2403781 ZFYVE28 -0.33 -5.45 -0.32 1.15e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06697439 chr19:59031463 ZBTB45 -0.6 -7.26 -0.41 4.25e-12 Gut microbiome composition (summer); CESC cis rs854765 0.693 rs4924823 chr17:17764502 A/G cg16928487 chr17:17741425 SREBF1 0.55 9.67 0.51 3.93e-19 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09744376 chr3:53080176 SFMBT1 0.59 6.85 0.39 5.22e-11 Gut microbiome composition (summer); CESC cis rs11025559 0.812 rs10833336 chr11:20514288 C/G cg19653624 chr11:20408972 PRMT3 -0.44 -5.05 -0.3 8.25e-7 Pursuit maintenance gain; CESC cis rs9790314 0.740 rs4856767 chr3:161004379 C/T cg03342759 chr3:160939853 NMD3 -0.52 -7.47 -0.42 1.18e-12 Morning vs. evening chronotype; CESC cis rs870825 0.616 rs7654208 chr4:185648877 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05714672 chr3:15469004 METTL6;EAF1 0.58 6.67 0.38 1.47e-10 Gut microbiome composition (summer); CESC cis rs2486288 0.656 rs6493145 chr15:45573862 G/T cg09092052 chr15:45571596 NA 0.44 5.27 0.31 2.8e-7 Glomerular filtration rate; CESC cis rs11030122 0.702 rs10835407 chr11:3993231 C/T cg18678763 chr11:4115507 RRM1 0.47 6.22 0.36 1.88e-9 Mean platelet volume;Platelet distribution width; CESC cis rs782590 0.967 rs782588 chr2:55841640 T/C cg18811423 chr2:55921094 PNPT1 0.82 13.33 0.63 2.34e-31 Metabolic syndrome; CESC cis rs12477438 0.798 rs12477754 chr2:99628073 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.37 0.31 1.76e-7 Personality dimensions; CESC cis rs765787 0.530 rs4775837 chr15:45537684 G/T cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02908720 chr7:127292155 SND1 -0.41 -6.15 -0.35 2.88e-9 Gambling; CESC cis rs2267137 0.903 rs2283850 chr22:29772391 G/C cg07256473 chr22:29710276 RASL10A 0.42 6.5 0.37 4.08e-10 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs854765 0.647 rs854763 chr17:18010095 C/G cg16928487 chr17:17741425 SREBF1 -0.53 -8.5 -0.46 1.38e-15 Total body bone mineral density; CESC cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.91 0.48 8.46e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs10883723 0.810 rs2296589 chr10:104248106 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.48 0.42 1.09e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs4523957 0.928 rs6502155 chr17:2176964 A/G cg16513277 chr17:2031491 SMG6 -0.59 -8.07 -0.44 2.41e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9815354 0.680 rs73073301 chr3:42028777 T/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs9916302 0.904 rs755500 chr17:37409865 C/T cg15445000 chr17:37608096 MED1 0.39 6.21 0.36 2.02e-9 Glomerular filtration rate (creatinine); CESC trans rs3749237 1.000 rs11920900 chr3:49823024 G/C cg21659725 chr3:3221576 CRBN 0.53 6.33 0.36 1.04e-9 Resting heart rate; CESC cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.47 -0.32 1.06e-7 Total body bone mineral density; CESC cis rs12477438 0.520 rs6717729 chr2:99756941 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.37 0.69 1.49e-38 Chronic sinus infection; CESC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.34 -0.31 1.98e-7 Developmental language disorder (linguistic errors); CESC cis rs9443189 0.570 rs72884926 chr6:76266208 T/C cg01950844 chr6:76311363 SENP6 0.86 9.09 0.49 2.37e-17 Prostate cancer; CESC cis rs7394190 0.748 rs78790589 chr10:75539598 G/A cg07699608 chr10:75541558 CHCHD1 0.64 5.28 0.31 2.63e-7 Incident atrial fibrillation; CESC cis rs10411936 0.785 rs2363120 chr19:16519871 C/A cg10248733 chr19:16607483 C19orf44;CALR3 -0.45 -5.56 -0.32 6.62e-8 White blood cell count;Multiple sclerosis; CESC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg11987759 chr7:65425863 GUSB -0.48 -6.56 -0.37 2.82e-10 Aortic root size; CESC cis rs9486719 0.947 rs11755945 chr6:96908038 G/C cg06623918 chr6:96969491 KIAA0776 -0.8 -8.21 -0.45 9.55e-15 Migraine;Coronary artery disease; CESC cis rs11785400 1.000 rs4518642 chr8:143737396 T/C cg10596483 chr8:143751796 JRK 0.43 5.67 0.33 3.65e-8 Schizophrenia; CESC cis rs4595586 0.545 rs6580895 chr12:39372011 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.15 -0.4 8.31e-12 Morning vs. evening chronotype; CESC cis rs9916302 0.904 rs4795357 chr17:37569551 T/C cg07936489 chr17:37558343 FBXL20 -0.78 -10.65 -0.55 2.75e-22 Glomerular filtration rate (creatinine); CESC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.69 8.35 0.46 3.94e-15 Age-related macular degeneration (geographic atrophy); CESC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.62 0.58 1.72e-25 Alzheimer's disease; CESC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg10295955 chr4:187884368 NA -1.05 -18.46 -0.75 1.69e-49 Lobe attachment (rater-scored or self-reported); CESC cis rs763121 0.853 rs2179142 chr22:39037954 G/A cg06022373 chr22:39101656 GTPBP1 0.92 15.05 0.68 2.09e-37 Menopause (age at onset); CESC cis rs7089973 0.604 rs2420067 chr10:116590348 A/G cg25233709 chr10:116636983 FAM160B1 0.38 5.9 0.34 1.12e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1008375 0.806 rs13139898 chr4:17706928 T/G cg16339924 chr4:17578868 LAP3 -0.66 -7.93 -0.44 6.23e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs17125944 0.615 rs7151643 chr14:53313661 G/C cg00686598 chr14:53173677 PSMC6 -0.56 -5.09 -0.3 6.79e-7 Alzheimer's disease (late onset); CESC cis rs36051895 0.664 rs11788834 chr9:5092466 G/A cg02405213 chr9:5042618 JAK2 -0.52 -6.38 -0.36 7.97e-10 Pediatric autoimmune diseases; CESC cis rs7020830 0.867 rs7852593 chr9:37332380 A/T cg14294708 chr9:37120828 ZCCHC7 1.23 23.26 0.82 5.6e-66 Schizophrenia; CESC cis rs1062177 1.000 rs2915869 chr5:151171509 C/T cg00977110 chr5:151150581 G3BP1 0.66 7.11 0.4 1.06e-11 Preschool internalizing problems; CESC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.62 0.38 1.95e-10 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11167532 chr17:46570090 NA 0.51 6.79 0.38 7.55e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs877282 0.891 rs11253406 chr10:796297 G/A cg22713356 chr15:30763199 NA 1.32 13.47 0.64 7.47e-32 Uric acid levels; CESC cis rs7914558 1.000 rs2275271 chr10:104814162 T/C cg04362960 chr10:104952993 NT5C2 0.47 6.32 0.36 1.11e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg01171360 chr6:293285 DUSP22 -0.68 -9.18 -0.49 1.29e-17 Menopause (age at onset); CESC cis rs7264396 0.635 rs6058375 chr20:34531997 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -10.89 -0.56 4.64e-23 Total cholesterol levels; CESC cis rs11048434 0.698 rs1805745 chr12:9065226 A/T cg04155231 chr12:9217510 LOC144571 0.33 5.32 0.31 2.16e-7 Sjögren's syndrome; CESC cis rs60154123 0.505 rs76426571 chr1:210041634 C/T cg22029157 chr1:209979665 IRF6 0.72 7.16 0.4 8.04e-12 Coronary artery disease; CESC cis rs854765 0.583 rs4414547 chr17:17859052 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg02935154 chr7:12443704 VWDE -0.59 -6.31 -0.36 1.14e-9 Coronary artery disease; CESC cis rs8067545 1.000 rs2108979 chr17:19928566 G/A cg13482628 chr17:19912719 NA 0.42 5.63 0.33 4.61e-8 Schizophrenia; CESC cis rs6752107 1.000 rs3828309 chr2:234180410 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.44 -5.73 -0.33 2.66e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs11098499 0.863 rs7657849 chr4:120455494 T/C cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg06108461 chr20:60628389 TAF4 0.63 8.38 0.46 3.16e-15 Body mass index; CESC cis rs4237845 0.837 rs7954957 chr12:58299250 C/T cg00677455 chr12:58241039 CTDSP2 0.43 5.62 0.33 4.88e-8 Intelligence (multi-trait analysis); CESC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg18404041 chr3:52824283 ITIH1 0.39 6.72 0.38 1.12e-10 Bipolar disorder; CESC cis rs2242194 0.816 rs11264296 chr1:154994750 T/C cg09359103 chr1:154839909 KCNN3 -0.41 -6.61 -0.38 2.14e-10 Schizophrenia; CESC cis rs9788682 1.000 rs7163730 chr15:78814681 A/G cg06917634 chr15:78832804 PSMA4 -0.54 -6.36 -0.36 8.71e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7809950 0.598 rs2283038 chr7:106835410 C/T cg23024343 chr7:107201750 COG5 -0.56 -6.79 -0.38 7.33e-11 Coronary artery disease; CESC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg21906852 chr1:75198582 TYW3;CRYZ -0.4 -5.15 -0.3 4.97e-7 Resistin levels; CESC cis rs10791097 0.694 rs1054869 chr11:130742630 G/A cg12179176 chr11:130786555 SNX19 0.65 10.07 0.53 2.16e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs16854884 0.537 rs16855026 chr3:143868350 A/C cg01302019 chr3:143689584 C3orf58 -0.35 -5.34 -0.31 2.01e-7 Economic and political preferences (feminism/equality); CESC cis rs9362426 1.000 rs6930076 chr6:88088654 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.49 6.13 0.35 3.09e-9 Depressive episodes in bipolar disorder; CESC cis rs11630290 0.592 rs4777332 chr15:64158112 A/G cg12036633 chr15:63758958 NA 0.45 5.34 0.31 2e-7 Iris characteristics; CESC trans rs57221529 0.766 rs12522140 chr5:587261 C/A cg25482853 chr8:67687455 SGK3 1.01 9.99 0.52 3.67e-20 Lung disease severity in cystic fibrosis; CESC cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg26408565 chr15:76604113 ETFA -0.42 -6.37 -0.36 8.13e-10 Blood metabolite levels; CESC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.29 -0.36 1.31e-9 Menopause (age at onset); CESC cis rs4700695 0.719 rs40176 chr5:65464965 C/T cg21114390 chr5:65439923 SFRS12 -0.48 -5.85 -0.34 1.46e-8 Facial morphology (factor 19); CESC cis rs4474465 0.920 rs7947824 chr11:78223731 C/G cg02023728 chr11:77925099 USP35 -0.41 -5.21 -0.3 3.78e-7 Alzheimer's disease (survival time); CESC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg14829155 chr15:31115871 NA -0.72 -9.75 -0.51 2.15e-19 Huntington's disease progression; CESC cis rs1499614 1.000 rs2707838 chr7:66159201 C/T cg12463550 chr7:65579703 CRCP 0.73 5.73 0.33 2.78e-8 Gout; CESC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.83 8.3 0.45 5.39e-15 Platelet count; CESC cis rs1215050 0.740 rs1084777 chr4:99017542 C/T cg17366294 chr4:99064904 C4orf37 -0.4 -5.31 -0.31 2.3e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg22920501 chr2:26401640 FAM59B -0.67 -8.12 -0.45 1.72e-14 Gut microbiome composition (summer); CESC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg24060327 chr5:131705240 SLC22A5 0.76 10.65 0.55 2.72e-22 Blood metabolite levels; CESC cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg04455712 chr21:45112962 RRP1B 0.4 5.93 0.34 9.32e-9 Mean corpuscular volume; CESC cis rs524281 0.773 rs10791863 chr11:66027358 C/T cg14036092 chr11:66035641 RAB1B -0.55 -5.38 -0.31 1.62e-7 Electroencephalogram traits; CESC cis rs7772486 0.875 rs11755334 chr6:146399297 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.57 0.37 2.58e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs11690935 0.959 rs7608403 chr2:172646765 A/C cg13550731 chr2:172543902 DYNC1I2 -1.01 -16.71 -0.72 2.64e-43 Schizophrenia; CESC cis rs9322193 0.847 rs868375 chr6:150166041 T/A cg04369109 chr6:150039330 LATS1 -0.42 -5.6 -0.33 5.35e-8 Lung cancer; CESC cis rs9815354 0.812 rs73071356 chr3:41829486 C/T cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs644799 0.965 rs10831425 chr11:95500628 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.94 15.21 0.68 5.57e-38 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs60843830 1.000 rs59937473 chr2:271797 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.88 12.15 0.6 2.66e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs6540559 0.546 rs7551944 chr1:210029430 G/C cg25204440 chr1:209979598 IRF6 0.66 5.89 0.34 1.19e-8 Cleft lip with or without cleft palate; CESC cis rs17655565 0.553 rs7956996 chr12:52724938 C/T cg00777198 chr12:52828273 KRT75 0.36 5.25 0.31 3.07e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg19622623 chr12:86230825 RASSF9 -0.43 -5.27 -0.31 2.78e-7 Major depressive disorder; CESC cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg03433033 chr1:76189801 ACADM 0.72 10.17 0.53 1.02e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2625529 0.689 rs2957742 chr15:72302894 C/G cg16672083 chr15:72433130 SENP8 0.4 6.17 0.35 2.51e-9 Red blood cell count; CESC cis rs4835473 0.897 rs4835454 chr4:144651234 C/T cg25736465 chr4:144833511 NA 0.36 5.42 0.32 1.31e-7 Immature fraction of reticulocytes; CESC cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg21395723 chr22:39101663 GTPBP1 -0.42 -5.15 -0.3 5e-7 Menopause (age at onset); CESC cis rs477692 0.663 rs491929 chr10:131368111 G/A cg05714579 chr10:131428358 MGMT 0.41 5.37 0.31 1.7e-7 Response to temozolomide; CESC cis rs4728302 0.869 rs6954712 chr7:133618853 G/A cg10665199 chr7:133106180 EXOC4 0.4 5.34 0.31 1.98e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg23172400 chr8:95962367 TP53INP1 -0.44 -9.04 -0.49 3.45e-17 Type 2 diabetes; CESC cis rs9908102 0.710 rs7215456 chr17:12900675 A/C cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02729269 chr16:127772 MPG 0.49 6.23 0.36 1.83e-9 Gut microbiome composition (summer); CESC trans rs55863869 0.748 rs2291309 chr2:179623577 G/T cg24136754 chr22:37403978 C22orf33 0.44 6.07 0.35 4.34e-9 QT interval; CESC cis rs4141404 0.561 rs5994376 chr22:31563555 A/C cg13145458 chr22:31556086 RNF185 0.42 5.1 0.3 6.61e-7 Paclitaxel-induced neuropathy; CESC cis rs2072732 0.808 rs55784203 chr1:2936754 G/T cg15211996 chr1:2936768 ACTRT2 0.34 5.51 0.32 8.71e-8 Plateletcrit; CESC cis rs2072499 0.966 rs2853641 chr1:156181770 A/G cg25208724 chr1:156163844 SLC25A44 0.88 16.16 0.7 2.43e-41 Testicular germ cell tumor; CESC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg24562669 chr7:97807699 LMTK2 0.51 7.43 0.42 1.51e-12 Prostate cancer (SNP x SNP interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21515243 chr18:21033072 RIOK3 -0.46 -6.92 -0.39 3.3e-11 Gambling; CESC cis rs9815354 1.000 rs9820192 chr3:41889281 G/A cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.48e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs858239 0.600 rs7789237 chr7:23124713 T/G cg23682824 chr7:23144976 KLHL7 0.54 7.54 0.42 7.42e-13 Cerebrospinal fluid biomarker levels; CESC cis rs9611565 0.568 rs2413656 chr22:42129357 G/T cg03806693 chr22:41940476 POLR3H 0.77 9.39 0.5 2.95e-18 Vitiligo; CESC cis rs754466 0.580 rs1054608 chr10:79543308 T/G cg17075019 chr10:79541650 NA -0.87 -13.99 -0.65 1.09e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7703051 0.829 rs7733436 chr5:74666492 C/T cg03227963 chr5:74354835 NA 0.29 5.34 0.31 1.99e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs2180341 0.924 rs877661 chr6:127587915 T/G cg24812749 chr6:127587940 RNF146 1.07 15.61 0.69 2.13e-39 Breast cancer; CESC cis rs854765 0.547 rs2955385 chr17:17939247 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.76 0.47 2.3e-16 Total body bone mineral density; CESC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg24209194 chr3:40518798 ZNF619 0.49 6.23 0.36 1.78e-9 Renal cell carcinoma; CESC cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg18225595 chr11:63971243 STIP1 0.62 8.77 0.47 2.15e-16 Platelet count; CESC cis rs4835473 0.838 rs34819068 chr4:144708483 C/G cg25736465 chr4:144833511 NA -0.35 -5.61 -0.33 5e-8 Immature fraction of reticulocytes; CESC cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg23711669 chr6:146136114 FBXO30 0.92 11.95 0.59 1.27e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs34779708 0.897 rs7900480 chr10:35338699 A/G cg04310649 chr10:35416472 CREM 0.55 6.49 0.37 4.13e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs3740713 1.000 rs76708296 chr11:18456133 A/T cg23797887 chr11:18477753 LDHAL6A -0.53 -5.11 -0.3 6.1e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7692995 1.000 rs13151431 chr4:17959581 C/A cg08925142 chr4:18023851 LCORL -0.45 -5.13 -0.3 5.66e-7 Height; CESC cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg01579765 chr21:45077557 HSF2BP 0.5 8.92 0.48 7.75e-17 Mean corpuscular volume; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25789201 chr7:72395803 POM121 0.49 6.52 0.37 3.61e-10 Systemic lupus erythematosus; CESC cis rs2749592 0.531 rs994804 chr10:37900140 A/C cg00409905 chr10:38381863 ZNF37A 0.43 5.69 0.33 3.28e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs644148 0.748 rs542150 chr19:44967453 T/C cg15540054 chr19:45004280 ZNF180 0.59 6.46 0.37 4.92e-10 Personality dimensions; CESC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs6088580 0.634 rs2378134 chr20:32938085 C/T cg06115741 chr20:33292138 TP53INP2 -0.43 -5.4 -0.32 1.45e-7 Glomerular filtration rate (creatinine); CESC cis rs8016982 1.000 rs8016982 chr14:81707057 C/T cg01989461 chr14:81687754 GTF2A1 0.53 6.9 0.39 3.81e-11 Schizophrenia; CESC cis rs9486719 1.000 rs2971608 chr6:97039757 T/C cg06623918 chr6:96969491 KIAA0776 -0.86 -10.44 -0.54 1.35e-21 Migraine;Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02878701 chr21:47706221 MCM3AP;C21orf57 0.59 6.55 0.37 3.01e-10 Gut microbiome composition (summer); CESC trans rs9929218 0.953 rs28608872 chr16:68802038 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.44 -0.46 2.13e-15 Colorectal cancer; CESC cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.96 14.51 0.67 1.65e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1847202 0.717 rs13063437 chr3:72952388 A/G cg25664220 chr3:72788482 NA -0.4 -5.74 -0.33 2.55e-8 Motion sickness; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25080152 chr8:128748155 MYC -0.46 -6.1 -0.35 3.75e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs35110281 0.840 rs7276633 chr21:45078800 C/T cg21573476 chr21:45109991 RRP1B -0.49 -6.92 -0.39 3.41e-11 Mean corpuscular volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07352798 chr5:141488591 NDFIP1 -0.44 -6.06 -0.35 4.67e-9 Ulcerative colitis; CESC cis rs1020064 0.636 rs1529975 chr2:105929901 T/C cg02079111 chr2:105885981 TGFBRAP1 0.38 5.19 0.3 4.15e-7 AIDS; CESC trans rs7666738 0.830 rs4292341 chr4:98959724 C/T cg19256675 chr7:74988891 PMS2L2;STAG3L1 0.44 6.02 0.35 5.68e-9 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14929266 chr13:113864086 CUL4A;PCID2 0.53 6.0 0.35 6.43e-9 Gut microbiome composition (summer); CESC cis rs523522 0.962 rs12814055 chr12:120987391 G/A cg12219531 chr12:120966889 COQ5 0.75 9.9 0.52 7e-20 High light scatter reticulocyte count; CESC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg24675658 chr1:53192096 ZYG11B -0.52 -6.6 -0.38 2.19e-10 Monocyte count; CESC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.53 -0.32 7.83e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9549367 0.774 rs9549364 chr13:113903745 T/C cg18105134 chr13:113819100 PROZ -0.68 -8.25 -0.45 7.53e-15 Platelet distribution width; CESC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.97 0.8 1.29e-61 Prudent dietary pattern; CESC cis rs7116495 0.609 rs4945392 chr11:71694645 C/T cg18441811 chr11:71824068 C11orf51 -0.82 -5.33 -0.31 2.05e-7 Severe influenza A (H1N1) infection; CESC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.64 0.38 1.81e-10 Prudent dietary pattern; CESC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.67 0.38 1.48e-10 Bipolar disorder; CESC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg22433210 chr17:43662623 NA 0.58 7.25 0.41 4.48e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg00149659 chr3:10157352 C3orf10 0.74 8.69 0.47 3.76e-16 Alzheimer's disease; CESC cis rs4423214 0.840 rs1790328 chr11:71148038 G/A cg05163923 chr11:71159392 DHCR7 -0.61 -7.24 -0.41 4.76e-12 Vitamin D levels; CESC cis rs7833986 0.501 rs2953910 chr8:56968761 C/G cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.16 0.3 4.9e-7 Height; CESC cis rs55986470 0.670 rs56313033 chr2:239346202 C/T cg18131467 chr2:239335373 ASB1 -0.67 -5.56 -0.32 6.65e-8 Chronotype; CESC cis rs7193541 0.929 rs12933037 chr16:74660174 G/A cg01733217 chr16:74700730 RFWD3 0.9 13.16 0.63 9.03e-31 Multiple myeloma; CESC cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.82 10.47 0.54 1.04e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg08632164 chr7:65971372 NA 0.32 5.2 0.3 3.94e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14501914 chr9:131219228 ODF2 -0.44 -6.01 -0.35 6.14e-9 Fibrinogen levels; CESC cis rs3820928 0.874 rs13423714 chr2:227896652 C/G cg05526886 chr2:227700861 RHBDD1 0.43 5.34 0.31 2.02e-7 Pulmonary function; CESC cis rs2479106 0.549 rs10986070 chr9:126366529 C/T cg16191174 chr9:126692580 DENND1A -0.38 -5.26 -0.31 2.96e-7 Polycystic ovary syndrome; CESC cis rs3857067 1.000 rs1397026 chr4:95013729 A/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs2304069 0.507 rs7728264 chr5:149394954 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.47 6.36 0.36 8.69e-10 HIV-1 control; CESC cis rs10129255 0.957 rs12590667 chr14:107187462 A/G cg07958169 chr14:107095056 NA 0.44 6.2 0.36 2.11e-9 Kawasaki disease; CESC cis rs10927875 0.526 rs35340817 chr1:16178917 T/C cg21385522 chr1:16154831 NA -0.92 -10.54 -0.54 6.39e-22 Dilated cardiomyopathy; CESC cis rs7727544 0.684 rs611084 chr5:131709739 A/C cg24060327 chr5:131705240 SLC22A5 0.63 8.31 0.45 5.15e-15 Blood metabolite levels; CESC trans rs2727020 0.619 rs11040300 chr11:49269984 C/A cg03929089 chr4:120376271 NA 0.71 8.65 0.47 5.16e-16 Coronary artery disease; CESC cis rs9302635 0.513 rs12928732 chr16:72188683 C/T cg01557791 chr16:72042693 DHODH -0.63 -7.08 -0.4 1.33e-11 Blood protein levels; CESC cis rs1153858 1.000 rs12101539 chr15:45650666 C/G cg14582100 chr15:45693742 SPATA5L1 0.43 6.15 0.35 2.82e-9 Homoarginine levels; CESC cis rs4566357 0.557 rs6707158 chr2:227911269 A/G cg11843606 chr2:227700838 RHBDD1 -0.47 -6.49 -0.37 4.32e-10 Coronary artery disease; CESC cis rs2737618 0.722 rs2737680 chr1:200088559 C/A cg21825944 chr1:200113062 NR5A2 -0.45 -6.73 -0.38 1.02e-10 Uric acid levels; CESC cis rs9815354 0.812 rs17282671 chr3:41887455 T/C cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.84e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs2066819 1.000 rs80317430 chr12:56727705 G/A cg26714650 chr12:56694279 CS -1.39 -9.17 -0.49 1.33e-17 Psoriasis vulgaris; CESC cis rs9549367 0.713 rs4907593 chr13:113830459 C/T cg18105134 chr13:113819100 PROZ 0.55 7.14 0.4 8.88e-12 Platelet distribution width; CESC cis rs7843479 0.601 rs4872209 chr8:21848832 A/T cg17168535 chr8:21777572 XPO7 0.73 11.62 0.58 1.7e-25 Mean corpuscular volume; CESC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7833986 0.501 rs2667981 chr8:56894303 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.16 0.4 8.04e-12 Height; CESC cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg27398817 chr8:82754497 SNX16 -0.55 -6.41 -0.37 6.75e-10 Diastolic blood pressure; CESC cis rs1801251 0.964 rs6748027 chr2:233629552 T/C cg08000102 chr2:233561755 GIGYF2 0.67 9.48 0.5 1.53e-18 Coronary artery disease; CESC cis rs12545109 0.800 rs2576592 chr8:57419357 A/C cg09654669 chr8:57350985 NA -0.45 -6.27 -0.36 1.47e-9 Obesity-related traits; CESC cis rs12079745 0.793 rs78483993 chr1:169410428 G/A cg09363564 chr1:169337483 NME7;BLZF1 -1.26 -7.33 -0.41 2.72e-12 QT interval; CESC cis rs2522056 1.000 rs2522056 chr5:131801726 C/T cg07395648 chr5:131743802 NA 0.43 5.13 0.3 5.66e-7 Lymphocyte counts;Fibrinogen; CESC cis rs2412488 0.893 rs6822201 chr4:54359743 T/C cg22241045 chr4:54363911 LNX1 -0.39 -5.32 -0.31 2.2e-7 DNA methylation (variation); CESC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.18 0.53 9.01e-21 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04882175 chr6:131122610 NA -0.61 -6.67 -0.38 1.44e-10 Gut microbiome composition (summer); CESC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg26343298 chr8:95960752 TP53INP1 0.37 6.14 0.35 3.07e-9 Type 2 diabetes; CESC cis rs72781680 0.898 rs7589440 chr2:24038595 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs3806843 1.000 rs1476768 chr5:140173597 G/A cg26395211 chr5:140044315 WDR55 -0.42 -5.35 -0.31 1.9e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2932538 0.922 rs12750023 chr1:113118329 G/A cg22162597 chr1:113214053 CAPZA1 0.54 6.95 0.39 2.77e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs12477438 0.798 rs10196680 chr2:99628617 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs7561273 0.586 rs6545264 chr2:24310105 A/G cg20701182 chr2:24300061 SF3B14 0.52 6.69 0.38 1.3e-10 Quantitative traits; CESC cis rs67311347 1.000 rs2305522 chr3:40429358 A/G cg09455208 chr3:40491958 NA 0.45 7.7 0.43 2.71e-13 Renal cell carcinoma; CESC cis rs9399137 0.507 rs4520025 chr6:135278619 G/T cg24558204 chr6:135376177 HBS1L 0.71 9.64 0.51 4.75e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg11764359 chr7:65958608 NA -0.69 -9.06 -0.49 2.98e-17 Aortic root size; CESC cis rs7527798 0.592 rs4097398 chr1:207857760 C/T cg21110645 chr1:207815933 NA -0.33 -5.86 -0.34 1.33e-8 Erythrocyte sedimentation rate; CESC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.24 -0.41 4.79e-12 Developmental language disorder (linguistic errors); CESC cis rs208520 0.690 rs1580430 chr6:66715162 T/A cg07460842 chr6:66804631 NA 0.96 13.01 0.62 2.95e-30 Exhaled nitric oxide output; CESC cis rs9486719 0.947 rs6916232 chr6:96985959 A/T cg06623918 chr6:96969491 KIAA0776 0.77 8.17 0.45 1.26e-14 Migraine;Coronary artery disease; CESC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs8018808 1.000 rs8018808 chr14:77858336 A/G cg20045696 chr14:77926864 AHSA1 -0.37 -5.06 -0.3 7.85e-7 Myeloid white cell count; CESC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg03609598 chr5:56110824 MAP3K1 -0.51 -5.32 -0.31 2.22e-7 Initial pursuit acceleration; CESC cis rs7621025 0.505 rs34281413 chr3:136461860 C/T cg15507776 chr3:136538369 TMEM22 -0.81 -7.29 -0.41 3.66e-12 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs3806843 0.933 rs2240696 chr5:140168070 A/G cg26395211 chr5:140044315 WDR55 -0.42 -5.43 -0.32 1.26e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7116495 1.000 rs10736786 chr11:71763274 C/T cg10381502 chr11:71823885 C11orf51 -0.66 -5.36 -0.31 1.81e-7 Severe influenza A (H1N1) infection; CESC cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg05754148 chr16:3507555 NAT15 -0.58 -8.48 -0.46 1.62e-15 Tuberculosis; CESC cis rs2204008 0.837 rs7308714 chr12:38274307 T/C cg13010199 chr12:38710504 ALG10B 0.48 6.04 0.35 5.23e-9 Bladder cancer; CESC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg08109568 chr15:31115862 NA -0.65 -9.24 -0.49 8.28e-18 Huntington's disease progression; CESC cis rs9902453 0.868 rs8066731 chr17:28523121 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 8.09 0.45 2.15e-14 Coffee consumption (cups per day); CESC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.07 -13.11 -0.63 1.33e-30 Gut microbiome composition (summer); CESC cis rs6570726 0.846 rs411468 chr6:145832792 A/G cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg22535103 chr8:58192502 C8orf71 -0.9 -8.95 -0.48 6.29e-17 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg06873352 chr17:61820015 STRADA 0.72 12.8 0.62 1.61e-29 Prudent dietary pattern; CESC cis rs7927592 0.763 rs11822059 chr11:68300822 T/G cg01657329 chr11:68192670 LRP5 -0.48 -6.38 -0.37 7.71e-10 Total body bone mineral density; CESC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg05552183 chr6:42928497 GNMT 0.77 11.93 0.59 1.55e-26 Alzheimer's disease in APOE e4+ carriers; CESC cis rs72781680 0.898 rs17763224 chr2:24213776 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.58 0.32 6.04e-8 Lymphocyte counts; CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.55 -7.18 -0.4 6.94e-12 Prudent dietary pattern; CESC cis rs1461503 0.934 rs930982 chr11:122834378 C/T cg27398637 chr11:122830231 C11orf63 -0.57 -8.43 -0.46 2.31e-15 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08408874 chr17:62493199 POLG2 0.58 6.37 0.36 8.14e-10 Gut microbiome composition (summer); CESC cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1568889 0.838 rs7125749 chr11:28154692 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 13.78 0.65 6.22e-33 Bipolar disorder; CESC cis rs4319547 0.910 rs6416298 chr12:123002143 C/T cg05707623 chr12:122985044 ZCCHC8 -0.56 -6.07 -0.35 4.33e-9 Body mass index; CESC cis rs2573652 0.722 rs12903458 chr15:100542673 T/G cg09918751 chr15:100517450 ADAMTS17 -0.31 -5.76 -0.33 2.28e-8 Height; CESC cis rs17601876 0.814 rs2414101 chr15:51562434 A/G cg19946085 chr15:51559439 CYP19A1 -0.34 -5.5 -0.32 8.88e-8 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs9837602 0.938 rs28503408 chr3:99794842 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.45 6.29 0.36 1.3e-9 Breast cancer; CESC cis rs2760061 0.603 rs697761 chr1:228192397 G/A cg02753203 chr1:228287806 NA 0.79 11.5 0.58 4.28e-25 Diastolic blood pressure; CESC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg00166722 chr3:10149974 C3orf24 0.48 5.95 0.34 8.64e-9 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21184926 chr2:198318139 COQ10B 0.57 6.82 0.39 6.13e-11 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg07507251 chr3:52567010 NT5DC2 0.41 7.21 0.4 5.94e-12 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03135535 chr4:141564017 TBC1D9 -0.57 -6.74 -0.38 9.62e-11 Gut microbiome composition (summer); CESC cis rs6688613 0.694 rs12562794 chr1:166828957 A/G ch.1.3259774R chr1:166827647 TADA1 0.58 5.87 0.34 1.33e-8 Refractive astigmatism; CESC trans rs9858542 0.953 rs9878943 chr3:49434654 G/A cg21659725 chr3:3221576 CRBN -0.54 -6.47 -0.37 4.62e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs73206853 0.843 rs12320025 chr12:110742991 A/G cg12870014 chr12:110450643 ANKRD13A 0.62 5.88 0.34 1.23e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9611565 0.592 rs57102627 chr22:41987627 T/C cg06481639 chr22:41940642 POLR3H -0.56 -6.32 -0.36 1.13e-9 Vitiligo; CESC trans rs2749592 0.550 rs9733309 chr10:37882405 G/A cg12057190 chr19:54976211 LENG9;CDC42EP5 -0.43 -6.16 -0.35 2.63e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7264396 0.580 rs6060648 chr20:34456704 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -9.22 -0.49 9.7e-18 Total cholesterol levels; CESC cis rs2835872 0.758 rs1709818 chr21:39036211 T/C cg06728970 chr21:39037746 KCNJ6 0.3 5.59 0.32 5.77e-8 Electroencephalographic traits in alcoholism; CESC cis rs7605827 0.930 rs1019359 chr2:15524615 T/C cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs10781543 0.845 rs10781540 chr9:139321836 G/A cg14019695 chr9:139328340 INPP5E 0.34 5.09 0.3 6.76e-7 Monocyte percentage of white cells; CESC cis rs941873 0.835 rs4246944 chr10:81105684 C/T cg09469691 chr10:81107165 PPIF 0.57 7.93 0.44 6.11e-14 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02656441 chr13:111367915 ING1 -0.53 -6.31 -0.36 1.18e-9 Gut microbiome composition (summer); CESC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg02071572 chr4:1403502 NA 0.38 5.88 0.34 1.26e-8 Longevity; CESC cis rs4423214 0.570 rs7118246 chr11:71231124 G/C cg24826892 chr11:71159390 DHCR7 0.5 5.65 0.33 4.19e-8 Vitamin D levels; CESC cis rs7301826 0.585 rs6486600 chr12:131292977 C/T cg11011512 chr12:131303247 STX2 0.49 5.98 0.35 7.05e-9 Plasma plasminogen activator levels; CESC cis rs4969178 0.965 rs12944051 chr17:76395856 C/T cg05887092 chr17:76393375 PGS1 -0.54 -8.3 -0.45 5.19e-15 HDL cholesterol levels; CESC cis rs79839061 0.732 rs56852661 chr4:826257 G/A cg07828340 chr4:882639 GAK 0.81 5.89 0.34 1.16e-8 Intelligence (multi-trait analysis); CESC cis rs660899 0.595 rs37456 chr1:44292989 C/T cg11704212 chr1:44303111 ST3GAL3 -0.41 -5.38 -0.31 1.65e-7 Hypertension risk in short sleep duration; CESC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg03709012 chr19:19516395 GATAD2A 0.98 14.6 0.67 8.23e-36 Tonsillectomy; CESC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg18876405 chr7:65276391 NA 0.5 6.68 0.38 1.43e-10 Aortic root size; CESC cis rs7772486 0.790 rs2254288 chr6:146204470 G/A cg23711669 chr6:146136114 FBXO30 0.82 11.79 0.59 4.46e-26 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20898347 chr17:21117939 TMEM11 -0.57 -6.19 -0.36 2.25e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18265938 chr17:55162298 AKAP1 0.6 7.03 0.4 1.8e-11 Gut microbiome composition (summer); CESC cis rs7592578 0.882 rs61117285 chr2:191468986 G/C cg10560079 chr2:191398806 TMEM194B -0.68 -6.16 -0.35 2.74e-9 Diastolic blood pressure; CESC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg04944784 chr2:26401820 FAM59B -0.63 -7.27 -0.41 3.93e-12 Gut microbiome composition (summer); CESC cis rs760805 1.000 rs61774728 chr1:25258867 G/C cg22509179 chr1:25234806 RUNX3 -0.6 -8.56 -0.47 9.51e-16 Allergic disease (asthma, hay fever or eczema); CESC cis rs2425143 0.818 rs35448195 chr20:34542365 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.1 -0.4 1.13e-11 Blood protein levels; CESC cis rs11792861 0.926 rs12683988 chr9:111867290 T/C cg13535736 chr9:111863775 C9orf5 -0.5 -6.66 -0.38 1.6e-10 Menarche (age at onset); CESC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg22433210 chr17:43662623 NA 0.96 11.5 0.58 4.39e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7707921 0.752 rs2406909 chr5:81276087 T/C cg15871215 chr5:81402204 ATG10 0.49 6.85 0.39 5.1e-11 Breast cancer; CESC cis rs7116495 1.000 rs10751193 chr11:71785356 A/C cg10381502 chr11:71823885 C11orf51 -0.68 -5.48 -0.32 9.68e-8 Severe influenza A (H1N1) infection; CESC cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg14393609 chr7:65229607 NA 0.41 5.23 0.31 3.51e-7 Aortic root size; CESC cis rs6084875 1.000 rs6084876 chr20:4742937 A/G cg05143360 chr20:4741328 NA -0.41 -5.48 -0.32 9.86e-8 Systemic lupus erythematosus; CESC cis rs644799 0.965 rs2950522 chr11:95524719 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.91 13.95 0.65 1.57e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg00475322 chr7:917719 C7orf20 0.46 5.1 0.3 6.53e-7 Cerebrospinal P-tau181p levels; CESC cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg05340658 chr4:99064831 C4orf37 0.74 10.46 0.54 1.18e-21 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.583 rs4257260 chr17:17857003 A/G cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06753985 chr16:1825890 EME2 0.48 6.77 0.38 8.03e-11 Fibrinogen levels; CESC cis rs12618769 0.681 rs72823792 chr2:99215142 G/A cg10123293 chr2:99228465 UNC50 0.4 5.19 0.3 4.2e-7 Bipolar disorder; CESC cis rs6942407 0.649 rs4727146 chr7:86856555 A/G cg02420886 chr7:86849541 C7orf23 0.56 5.27 0.31 2.77e-7 Food allergy; CESC cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg08822215 chr16:89438651 ANKRD11 -0.4 -6.24 -0.36 1.73e-9 Multiple myeloma (IgH translocation); CESC cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg21138405 chr5:131827807 IRF1 0.54 9.32 0.5 4.74e-18 Asthma (sex interaction); CESC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg05890377 chr2:74357713 NA 0.77 10.42 0.54 1.51e-21 Gestational age at birth (maternal effect); CESC cis rs2276314 1.000 rs56050783 chr18:33553791 A/G cg05985134 chr18:33552581 C18orf21 0.65 7.57 0.42 6.14e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg04511125 chr2:88470314 THNSL2 -0.43 -6.25 -0.36 1.66e-9 Response to metformin (IC50); CESC cis rs7264396 0.513 rs3787169 chr20:34419884 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.53 0.37 3.37e-10 Total cholesterol levels; CESC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg10053473 chr17:62856997 LRRC37A3 0.63 6.77 0.38 8.25e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg20699036 chr5:38556796 LIFR 0.51 6.58 0.37 2.46e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9682041 0.627 rs4955722 chr3:170102959 G/T cg11886554 chr3:170076028 SKIL 0.7 6.46 0.37 4.94e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs9467711 0.606 rs72841536 chr6:26378288 T/A cg12826209 chr6:26865740 GUSBL1 0.63 5.11 0.3 6.25e-7 Autism spectrum disorder or schizophrenia; CESC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg06873352 chr17:61820015 STRADA 0.49 7.1 0.4 1.17e-11 Height; CESC cis rs1348850 0.914 rs7587604 chr2:178309848 T/A cg22681709 chr2:178499509 PDE11A -0.39 -5.82 -0.34 1.71e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4141404 0.740 rs9609301 chr22:31895940 C/T cg02404636 chr22:31891804 SFI1 0.42 5.64 0.33 4.35e-8 Paclitaxel-induced neuropathy; CESC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.26 -0.31 2.95e-7 Developmental language disorder (linguistic errors); CESC cis rs4843747 0.518 rs4072777 chr16:88107030 G/A cg17633681 chr16:88106987 BANP 0.76 10.51 0.54 8.01e-22 Menopause (age at onset); CESC cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.04 12.08 0.6 4.54e-27 Smoking behavior; CESC cis rs17376456 1.000 rs66978370 chr5:93553633 G/A cg25358565 chr5:93447407 FAM172A 1.2 11.25 0.57 2.85e-24 Diabetic retinopathy; CESC cis rs6032067 0.641 rs17423617 chr20:43768050 G/C cg10761708 chr20:43804764 PI3 0.55 6.12 0.35 3.4e-9 Blood protein levels; CESC cis rs933688 1.000 rs12188467 chr5:90765632 A/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.0 12.25 0.6 1.24e-27 Smoking behavior; CESC cis rs9611565 0.694 rs202665 chr22:41814401 A/G cg06634786 chr22:41940651 POLR3H 0.72 7.58 0.42 5.66e-13 Vitiligo; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg15109221 chr6:15245772 JARID2 -0.52 -6.02 -0.35 5.85e-9 Gut microbiota (bacterial taxa); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00777555 chr3:57583074 ARF4 -0.44 -6.59 -0.38 2.36e-10 Gambling; CESC cis rs763121 0.853 rs4821816 chr22:39113134 G/A cg06544989 chr22:39130855 UNC84B 0.49 9.47 0.5 1.67e-18 Menopause (age at onset); CESC cis rs7267979 0.966 rs2257712 chr20:25264910 T/C cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs12599106 0.707 rs2163977 chr16:34916134 A/G cg11235426 chr6:292522 DUSP22 -0.67 -8.61 -0.47 6.51e-16 Menopause (age at onset); CESC cis rs6582630 0.576 rs4403871 chr12:38292193 G/A cg26384229 chr12:38710491 ALG10B -0.44 -5.59 -0.32 5.74e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9788682 0.894 rs4461039 chr15:78817447 A/T cg06917634 chr15:78832804 PSMA4 0.57 6.98 0.39 2.39e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs1797081 1.000 rs780634 chr10:16864327 T/G cg23933602 chr10:16859644 RSU1 1.13 24.93 0.84 1.94e-71 Platelet distribution width; CESC cis rs10489525 0.502 rs12026930 chr1:115597836 G/A cg01522456 chr1:115632236 TSPAN2 0.46 5.8 0.34 1.91e-8 Autism; CESC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg20607287 chr7:12443886 VWDE -0.7 -8.49 -0.46 1.46e-15 Coronary artery disease; CESC cis rs1707322 0.752 rs12024590 chr1:46127496 A/C cg05343316 chr1:45956843 TESK2 0.51 6.24 0.36 1.7e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs644799 0.562 rs515546 chr11:95588756 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.55 7.18 0.4 7.13e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg21280719 chr6:42927975 GNMT -0.29 -6.57 -0.37 2.72e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1728785 1.000 rs889561 chr16:68605741 G/A cg02972257 chr16:68554789 NA -0.68 -7.6 -0.42 5.05e-13 Ulcerative colitis; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg18404041 chr3:52824283 ITIH1 -0.35 -6.27 -0.36 1.45e-9 Hemoglobin concentration; CESC cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg05535760 chr7:792225 HEATR2 0.86 10.72 0.55 1.67e-22 Cerebrospinal P-tau181p levels; CESC cis rs7914558 0.966 rs10786721 chr10:104654383 C/A cg08650961 chr10:104748594 CNNM2 0.33 5.37 0.31 1.75e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2273669 0.667 rs11153155 chr6:109359963 G/A cg05315195 chr6:109294784 ARMC2 -0.67 -6.09 -0.35 3.97e-9 Prostate cancer; CESC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.43 -5.72 -0.33 2.86e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs2727020 0.530 rs7113153 chr11:49457957 G/A cg15704280 chr7:45808275 SEPT13 -0.81 -9.71 -0.51 2.94e-19 Coronary artery disease; CESC trans rs3942852 0.955 rs4752897 chr11:48136990 C/T cg15704280 chr7:45808275 SEPT13 -0.56 -6.31 -0.36 1.17e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs2637266 0.935 rs2579775 chr10:78401677 G/A cg18941641 chr10:78392320 NA 0.45 8.65 0.47 4.9e-16 Pulmonary function; CESC cis rs2070488 0.699 rs6599205 chr3:38529440 C/G cg24069376 chr3:38537580 EXOG 0.31 5.1 0.3 6.47e-7 Electrocardiographic conduction measures; CESC cis rs4835473 0.524 rs4404495 chr4:144900944 A/G cg25736465 chr4:144833511 NA 0.4 5.91 0.34 1.03e-8 Immature fraction of reticulocytes; CESC cis rs8017423 0.874 rs2149656 chr14:90707508 A/C cg14092571 chr14:90743983 NA -0.55 -8.08 -0.44 2.37e-14 Mortality in heart failure; CESC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg01988459 chr11:68622903 NA -0.4 -5.23 -0.31 3.38e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg18876405 chr7:65276391 NA 0.46 5.61 0.33 4.98e-8 Aortic root size; CESC cis rs7127900 0.614 rs11564708 chr11:2206326 C/G cg25635251 chr11:2234043 NA 0.48 5.32 0.31 2.26e-7 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); CESC cis rs727505 0.564 rs56068095 chr7:124831906 A/T cg23710748 chr7:124431027 NA -0.33 -5.1 -0.3 6.44e-7 Lewy body disease; CESC cis rs10779751 1.000 rs1205592 chr1:11305663 C/T cg08854313 chr1:11322531 MTOR 0.78 10.2 0.53 7.99e-21 Body mass index; CESC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.26 0.31 3e-7 Menopause (age at onset); CESC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg21248554 chr2:27665150 KRTCAP3 0.39 8.38 0.46 3.21e-15 Total body bone mineral density; CESC cis rs460214 0.539 rs28718905 chr21:40032244 C/A cg05519781 chr21:40033154 ERG -0.45 -5.41 -0.32 1.43e-7 Response to cognitive-behavioural therapy in anxiety disorder; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg23486179 chr3:49466665 NICN1 0.53 6.01 0.35 6.06e-9 Psoriatic arthritis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06988368 chr1:147142773 ACP6 -0.52 -6.79 -0.38 7.3e-11 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02204578 chr7:132766399 CHCHD3 -0.55 -6.5 -0.37 3.91e-10 Gut microbiome composition (summer); CESC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg27535305 chr1:53392650 SCP2 -0.34 -5.56 -0.32 6.75e-8 Monocyte count; CESC cis rs561341 1.000 rs546748 chr17:30324293 A/C cg00745463 chr17:30367425 LRRC37B -0.49 -5.42 -0.32 1.37e-7 Hip circumference adjusted for BMI; CESC cis rs4924935 1.000 rs11658555 chr17:18817486 C/T cg26378065 chr17:18585709 ZNF286B -0.52 -6.33 -0.36 1.06e-9 Pancreatic cancer; CESC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg26119090 chr2:26468346 HADHA;HADHB -1.05 -12.42 -0.61 3.18e-28 Gut microbiome composition (summer); CESC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg18876405 chr7:65276391 NA 0.5 6.64 0.38 1.75e-10 Aortic root size; CESC cis rs8072100 0.640 rs3851808 chr17:45425144 C/T cg25173405 chr17:45401733 C17orf57 -0.44 -5.48 -0.32 9.98e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26313349 chr1:145589328 NUDT17 -0.43 -6.04 -0.35 5.16e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9303280 0.901 rs12950743 chr17:38049233 T/C cg20243544 chr17:37824526 PNMT 0.51 6.7 0.38 1.27e-10 Self-reported allergy; CESC cis rs4803468 0.967 rs284661 chr19:41932120 C/T cg14132834 chr19:41945861 ATP5SL -0.6 -7.51 -0.42 8.94e-13 Height; CESC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg22800045 chr5:56110881 MAP3K1 0.76 8.79 0.48 1.93e-16 Initial pursuit acceleration; CESC cis rs34779708 1.000 rs34779708 chr10:35466185 T/G cg04310649 chr10:35416472 CREM -0.51 -6.12 -0.35 3.38e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs6537837 1.000 rs6537837 chr1:110119732 C/T cg05049280 chr1:110155535 GNAT2 0.41 5.83 0.34 1.58e-8 Major depressive disorder; CESC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg12034118 chr1:209979487 IRF6 0.43 5.36 0.31 1.8e-7 Cleft lip with or without cleft palate; CESC cis rs2573652 1.000 rs11634977 chr15:100516472 G/A cg00587665 chr15:100533223 ADAMTS17 -0.41 -6.71 -0.38 1.2e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19099736 chr22:29702810 GAS2L1 0.53 6.2 0.36 2.18e-9 Gut microbiome composition (summer); CESC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg21970626 chr13:21893289 NA -0.42 -6.09 -0.35 3.85e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs34779708 0.931 rs4934524 chr10:35270921 G/C cg03585969 chr10:35415529 CREM 0.77 10.13 0.53 1.39e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7917772 0.565 rs61869210 chr10:104437175 A/C cg04362960 chr10:104952993 NT5C2 -0.46 -5.04 -0.3 8.45e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs10489525 0.599 rs7526323 chr1:115604241 G/A cg01522456 chr1:115632236 TSPAN2 0.5 6.03 0.35 5.63e-9 Autism; CESC cis rs7219021 1.000 rs2032844 chr17:46847364 C/A cg16584676 chr17:46985605 UBE2Z -0.64 -7.23 -0.41 5.13e-12 Schizophrenia or bipolar disorder; CESC cis rs1559088 0.895 rs7259582 chr19:33593979 A/G cg17764715 chr19:33622953 WDR88 0.49 6.32 0.36 1.11e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6474412 1.000 rs13277254 chr8:42549982 G/A cg25026480 chr8:42547641 NA 0.33 5.1 0.3 6.57e-7 Smoking behavior; CESC cis rs11190604 1.000 rs4919468 chr10:102288343 G/C cg07080220 chr10:102295463 HIF1AN 0.66 6.02 0.35 5.76e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs193541 0.632 rs7729834 chr5:122122159 A/G cg19412675 chr5:122181750 SNX24 0.45 5.27 0.31 2.86e-7 Glucose homeostasis traits; CESC cis rs7084402 0.935 rs1593675 chr10:60291694 G/A cg07615347 chr10:60278583 BICC1 0.59 9.28 0.5 6.23e-18 Refractive error; CESC cis rs72781680 0.898 rs2339851 chr2:23938883 G/A cg08917208 chr2:24149416 ATAD2B 1.1 10.15 0.53 1.18e-20 Lymphocyte counts; CESC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 10.92 0.56 3.67e-23 Platelet count; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19552494 chr11:60674271 PRPF19 0.53 7.04 0.4 1.61e-11 Systemic lupus erythematosus; CESC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg08219700 chr8:58056026 NA 0.46 5.97 0.34 7.75e-9 Developmental language disorder (linguistic errors); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04665351 chr12:3000000 TULP3 -0.48 -6.97 -0.39 2.47e-11 Fibrinogen levels; CESC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg03517284 chr6:25882590 NA -0.42 -5.72 -0.33 2.89e-8 Intelligence (multi-trait analysis); CESC cis rs1005277 0.522 rs7072977 chr10:37940440 C/A cg25427524 chr10:38739819 LOC399744 -0.63 -9.11 -0.49 2.03e-17 Extrinsic epigenetic age acceleration; CESC cis rs858239 0.539 rs1358442 chr7:23189739 C/T cg23682824 chr7:23144976 KLHL7 0.51 6.83 0.39 5.81e-11 Cerebrospinal fluid biomarker levels; CESC cis rs2197308 0.765 rs11182964 chr12:37935052 C/T cg26384229 chr12:38710491 ALG10B 0.75 11.19 0.57 4.49e-24 Morning vs. evening chronotype; CESC cis rs7940866 0.774 rs7480903 chr11:130832276 A/G cg12179176 chr11:130786555 SNX19 0.67 10.26 0.53 5.15e-21 Schizophrenia; CESC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg22968622 chr17:43663579 NA 1.29 17.88 0.74 1.92e-47 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1215050 0.791 rs548892 chr4:98724701 C/T cg05340658 chr4:99064831 C4orf37 0.5 6.33 0.36 1.02e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs10992471 0.756 rs2761681 chr9:95186937 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -5.73 -0.33 2.77e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs7424096 0.613 rs111805423 chr2:37248924 G/T cg14987922 chr2:37194071 STRN 0.48 5.26 0.31 2.93e-7 High light scatter reticulocyte percentage of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06819360 chr2:231921616 PSMD1 0.51 6.16 0.35 2.66e-9 Gut microbiome composition (summer); CESC cis rs4891159 0.824 rs17059362 chr18:74144307 G/A cg24786174 chr18:74118243 ZNF516 -0.72 -10.87 -0.56 5.42e-23 Longevity; CESC cis rs17095355 0.901 rs11194947 chr10:111763731 A/T cg00817464 chr10:111662876 XPNPEP1 -0.54 -6.18 -0.35 2.46e-9 Biliary atresia; CESC cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg04972856 chr6:88032051 C6orf162;GJB7 0.36 5.61 0.33 5.17e-8 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18068487 chr7:150778340 FASTK;TMUB1 0.53 6.45 0.37 5.28e-10 Gut microbiome composition (summer); CESC cis rs11083475 0.599 rs7250443 chr19:39267345 T/C cg07905965 chr19:39260460 NA 0.36 5.35 0.31 1.94e-7 Heart rate; CESC cis rs9457247 0.765 rs4710171 chr6:167430186 A/G cg07741184 chr6:167504864 NA 0.36 6.6 0.38 2.26e-10 Crohn's disease; CESC cis rs4790333 0.813 rs2926992 chr17:2256026 C/A cg02569219 chr17:2266849 SGSM2 0.41 5.27 0.31 2.78e-7 Proinsulin levels; CESC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg16145915 chr7:1198662 ZFAND2A -0.61 -9.15 -0.49 1.55e-17 Longevity;Endometriosis; CESC cis rs7635838 0.684 rs2606750 chr3:11372151 T/C cg00170343 chr3:11313890 ATG7 0.54 7.77 0.43 1.73e-13 HDL cholesterol; CESC cis rs73206853 0.841 rs56209636 chr12:110841998 T/C cg12870014 chr12:110450643 ANKRD13A 0.63 5.23 0.31 3.48e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg22433210 chr17:43662623 NA -0.91 -10.81 -0.55 8.16e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7267979 1.000 rs2257985 chr20:25269743 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs6691722 0.503 rs12135404 chr1:24704263 C/T cg02336364 chr1:24764700 NIPAL3 -0.34 -6.99 -0.39 2.19e-11 Response to interferon beta in multiple sclerosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06722285 chr1:61925875 NFIA 0.42 6.52 0.37 3.61e-10 Gut microbiota (bacterial taxa); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17774305 chr12:50505649 C12orf62 0.49 6.48 0.37 4.33e-10 Gut microbiota (bacterial taxa); CESC cis rs3771570 1.000 rs56052835 chr2:242243251 T/G cg21155796 chr2:242212141 HDLBP 0.61 5.16 0.3 4.88e-7 Prostate cancer; CESC cis rs826838 0.616 rs4418873 chr12:38625473 C/A cg26384229 chr12:38710491 ALG10B 0.46 6.62 0.38 1.96e-10 Heart rate; CESC cis rs9473147 0.571 rs9369717 chr6:47554468 T/G cg20196966 chr6:47445060 CD2AP 0.41 5.29 0.31 2.59e-7 Platelet distribution width;Mean platelet volume; CESC cis rs9296736 0.890 rs9637973 chr6:53903152 C/T cg04374786 chr6:53939321 C6orf142 0.37 5.7 0.33 3.16e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 10.52 0.54 7.52e-22 Platelet count; CESC cis rs1784581 0.721 rs9365356 chr6:162414789 A/G cg17173639 chr6:162384350 PARK2 0.61 9.42 0.5 2.25e-18 Itch intensity from mosquito bite; CESC cis rs709400 1.000 rs3783404 chr14:104118498 A/G cg12935359 chr14:103987150 CKB -0.45 -6.08 -0.35 4.23e-9 Body mass index; CESC cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg18180107 chr4:99064573 C4orf37 0.53 6.31 0.36 1.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 5.02e-9 Prudent dietary pattern; CESC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg03647317 chr4:187891568 NA 0.42 5.85 0.34 1.42e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs2000999 0.524 rs36125653 chr16:72190805 G/A cg04254540 chr16:71951199 KIAA0174 -0.69 -5.63 -0.33 4.49e-8 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC cis rs727505 1.000 rs7795943 chr7:124483796 C/A cg23710748 chr7:124431027 NA -0.48 -7.6 -0.42 4.99e-13 Lewy body disease; CESC cis rs6060717 0.702 rs6060756 chr20:34608479 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.53 6.52 0.37 3.55e-10 Hip circumference adjusted for BMI; CESC cis rs1957429 0.520 rs230718 chr14:65318943 A/G cg23373153 chr14:65346875 NA -0.73 -5.65 -0.33 4.21e-8 Pediatric areal bone mineral density (radius); CESC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs3793917 0.948 rs3750847 chr10:124215421 C/T cg24884230 chr10:124216658 ARMS2 0.3 5.13 0.3 5.48e-7 Age-related macular degeneration; CESC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg18876405 chr7:65276391 NA 0.5 6.87 0.39 4.63e-11 Aortic root size; CESC cis rs1799949 0.965 rs7223952 chr17:41194885 T/C cg05368731 chr17:41323189 NBR1 0.58 7.93 0.44 6.04e-14 Menopause (age at onset); CESC cis rs698833 0.926 rs1067353 chr2:44666626 G/A cg04920474 chr2:44395004 PPM1B 0.36 5.04 0.3 8.57e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7769051 0.522 rs6934155 chr6:133124021 C/T cg07930552 chr6:133119739 C6orf192 1.14 7.79 0.43 1.5e-13 Type 2 diabetes nephropathy; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23892547 chr17:29886066 MIR193A -0.47 -6.19 -0.36 2.31e-9 Ulcerative colitis; CESC cis rs1387259 0.570 rs12368659 chr12:48562299 C/A cg24011408 chr12:48396354 COL2A1 0.49 7.42 0.41 1.59e-12 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs11741688 0.557 rs6600994 chr5:178336005 T/A cg20935368 chr5:178288625 ZNF354B 0.34 5.37 0.31 1.71e-7 Sleep duration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01068452 chr8:53626947 RB1CC1 0.56 6.37 0.36 8.55e-10 Gut microbiome composition (summer); CESC cis rs113835537 0.529 rs60358007 chr11:66222353 G/A cg22134325 chr11:66188745 NPAS4 0.44 6.67 0.38 1.49e-10 Airway imaging phenotypes; CESC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg08859206 chr1:53392774 SCP2 0.59 8.27 0.45 6.72e-15 Monocyte count; CESC cis rs72945132 0.882 rs66627443 chr11:70199036 C/G cg00319359 chr11:70116639 PPFIA1 0.73 6.97 0.39 2.49e-11 Coronary artery disease; CESC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.65e-39 Menopause (age at onset); CESC cis rs9790314 1.000 rs975323 chr3:161021322 A/G cg03342759 chr3:160939853 NMD3 -0.44 -5.77 -0.33 2.15e-8 Morning vs. evening chronotype; CESC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg07167872 chr1:205819463 PM20D1 -0.43 -6.24 -0.36 1.76e-9 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg10691866 chr7:65817282 TPST1 -0.32 -5.28 -0.31 2.73e-7 Aortic root size; CESC cis rs58235267 0.553 rs11890276 chr2:63366191 C/T cg17519650 chr2:63277830 OTX1 0.59 7.98 0.44 4.32e-14 Prostate-specific antigen levels (conditioned on lead SNPs); CESC cis rs7100689 0.622 rs1340373 chr10:82129250 G/A cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs7809950 1.000 rs3801944 chr7:107255548 T/C cg23024343 chr7:107201750 COG5 0.42 5.85 0.34 1.42e-8 Coronary artery disease; CESC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg08470875 chr2:26401718 FAM59B 0.61 5.77 0.33 2.25e-8 Gut microbiome composition (summer); CESC cis rs3540 0.533 rs7495080 chr15:91056681 G/A cg22089800 chr15:90895588 ZNF774 -0.62 -8.63 -0.47 5.79e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs2337406 0.500 rs57619050 chr14:107228305 G/A cg23076370 chr14:107095027 NA -0.52 -5.26 -0.31 3.04e-7 Alzheimer's disease (late onset); CESC cis rs9457247 0.765 rs9459838 chr6:167426599 C/G cg07741184 chr6:167504864 NA 0.36 6.65 0.38 1.62e-10 Crohn's disease; CESC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg04944784 chr2:26401820 FAM59B -0.66 -7.66 -0.43 3.61e-13 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.73 7.77 0.43 1.74e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs80130819 0.688 rs2634672 chr12:48649640 G/A cg05342945 chr12:48394962 COL2A1 -0.49 -5.33 -0.31 2.14e-7 Prostate cancer; CESC cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg25208724 chr1:156163844 SLC25A44 1.01 19.0 0.76 2.19e-51 Testicular germ cell tumor; CESC cis rs10779751 0.770 rs6674994 chr1:11239515 T/C cg08854313 chr1:11322531 MTOR 0.86 12.52 0.61 1.42e-28 Body mass index; CESC cis rs4523957 0.583 rs9907384 chr17:2045375 A/C cg16513277 chr17:2031491 SMG6 -0.75 -11.01 -0.56 1.89e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs910316 0.967 rs119076 chr14:75572419 G/T cg11812906 chr14:75593930 NEK9 -0.86 -14.71 -0.67 3.14e-36 Height; CESC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg04772025 chr11:68637568 NA 0.5 5.99 0.35 6.85e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7116495 1.000 rs2511116 chr11:71802160 G/A cg10381502 chr11:71823885 C11orf51 -0.66 -5.4 -0.31 1.51e-7 Severe influenza A (H1N1) infection; CESC cis rs67311347 0.955 rs6599100 chr3:40447362 C/T cg09455208 chr3:40491958 NA 0.46 7.82 0.43 1.24e-13 Renal cell carcinoma; CESC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg22336633 chr11:17099688 RPS13 0.48 6.28 0.36 1.41e-9 Schizophrenia; CESC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg03609598 chr5:56110824 MAP3K1 -0.54 -5.69 -0.33 3.42e-8 Initial pursuit acceleration; CESC cis rs662064 0.962 rs585870 chr1:10549628 G/T cg20482658 chr1:10539492 PEX14 -0.42 -8.87 -0.48 1.08e-16 Asthma; CESC cis rs12476592 0.602 rs964880 chr2:63826932 C/A cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC cis rs4481887 1.000 rs4244179 chr1:248470984 T/A cg00666640 chr1:248458726 OR2T12 0.41 6.65 0.38 1.71e-10 Common traits (Other); CESC cis rs6963495 0.818 rs73192145 chr7:105203628 A/C cg02135003 chr7:105160482 PUS7 -0.48 -5.62 -0.33 4.83e-8 Bipolar disorder (body mass index interaction); CESC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg16325326 chr1:53192061 ZYG11B 0.97 16.8 0.72 1.27e-43 Monocyte count; CESC cis rs34602589 0.535 rs7346579 chr20:43844722 A/G cg11264863 chr20:43835661 SEMG1 0.5 5.44 0.32 1.23e-7 Parental longevity (mother's age at death); CESC cis rs977987 0.778 rs12930452 chr16:75462055 A/G cg03315344 chr16:75512273 CHST6 0.41 5.93 0.34 9.41e-9 Dupuytren's disease; CESC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg10494973 chr17:80897199 TBCD -0.43 -5.29 -0.31 2.6e-7 Breast cancer; CESC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg11764359 chr7:65958608 NA 0.78 11.31 0.57 1.86e-24 Aortic root size; CESC cis rs9902453 0.765 rs2729447 chr17:28099002 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs8114671 0.562 rs7266550 chr20:33495510 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.19 0.3 4.19e-7 Height; CESC cis rs2243480 0.901 rs2949697 chr7:65464236 A/G cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC cis rs10883723 0.810 rs1884929 chr10:104275418 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.76e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg06877462 chr1:205807181 PM20D1 0.46 6.95 0.39 2.84e-11 Menarche (age at onset); CESC cis rs6831352 0.819 rs1154401 chr4:100009738 G/C cg12011299 chr4:100065546 ADH4 0.65 8.38 0.46 3.18e-15 Alcohol dependence; CESC cis rs10097731 0.901 rs4398860 chr8:82041753 C/T cg25230327 chr8:82042993 NA -0.59 -6.6 -0.38 2.28e-10 Serum total protein level; CESC cis rs644799 1.000 rs514170 chr11:95556696 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.76 0.38 8.51e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9916302 0.904 rs35335692 chr17:37710006 A/G cg00129232 chr17:37814104 STARD3 -0.57 -7.5 -0.42 9.44e-13 Glomerular filtration rate (creatinine); CESC cis rs9815354 0.680 rs73073291 chr3:42028004 G/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs11048434 0.636 rs7306161 chr12:9059075 T/A cg23795048 chr12:9217529 LOC144571 0.32 5.06 0.3 7.93e-7 Sjögren's syndrome; CESC cis rs7795096 0.512 rs7776488 chr7:151546696 G/A cg17008978 chr7:151542804 PRKAG2 0.35 5.52 0.32 7.96e-8 Bipolar disorder (age of onset and psychotic symptoms); CESC cis rs9300255 0.602 rs1716168 chr12:123651966 C/G cg05973401 chr12:123451056 ABCB9 -0.51 -5.84 -0.34 1.52e-8 Neutrophil percentage of white cells; CESC cis rs727505 0.721 rs67607629 chr7:124765867 C/T cg23710748 chr7:124431027 NA -0.34 -5.75 -0.33 2.41e-8 Lewy body disease; CESC cis rs11122272 0.638 rs2739514 chr1:231514806 G/A cg06096015 chr1:231504339 EGLN1 0.42 5.96 0.34 7.9e-9 Hemoglobin concentration; CESC cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.42 -0.32 1.37e-7 Developmental language disorder (linguistic errors); CESC cis rs6121246 0.865 rs6058421 chr20:30295013 G/C cg13852791 chr20:30311386 BCL2L1 0.8 8.48 0.46 1.57e-15 Mean corpuscular hemoglobin; CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg20151795 chr6:28129481 ZNF389 0.46 5.9 0.34 1.1e-8 Depression; CESC cis rs6543140 0.964 rs4851589 chr2:103077145 A/G cg04239558 chr2:103089729 SLC9A4 0.43 5.77 0.33 2.25e-8 Blood protein levels; CESC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.96 -0.34 8.05e-9 Cardiac Troponin-T levels; CESC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg17971929 chr21:40555470 PSMG1 -0.56 -7.41 -0.41 1.73e-12 Menarche (age at onset); CESC cis rs7833986 0.501 rs72653941 chr8:56942247 T/C cg26371346 chr8:56986568 SNORD54;RPS20 0.59 5.49 0.32 9.26e-8 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05815920 chr10:103880348 LDB1 -0.44 -6.06 -0.35 4.58e-9 Fibrinogen levels; CESC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg26338869 chr17:61819248 STRADA 0.68 8.97 0.48 5.62e-17 Prudent dietary pattern; CESC cis rs8018808 0.935 rs4899654 chr14:77867314 A/C cg20045696 chr14:77926864 AHSA1 0.4 5.55 0.32 7.09e-8 Myeloid white cell count; CESC cis rs769267 0.598 rs8108705 chr19:19675367 G/T cg03709012 chr19:19516395 GATAD2A -0.68 -8.39 -0.46 2.84e-15 Tonsillectomy; CESC cis rs7727544 0.735 rs2631370 chr5:131703776 T/C cg07395648 chr5:131743802 NA 0.41 5.3 0.31 2.4e-7 Blood metabolite levels; CESC cis rs10484885 0.887 rs2273246 chr6:90453263 A/G cg13799429 chr6:90582589 CASP8AP2 -0.68 -7.68 -0.43 3.1400000000000003e-13 QRS interval (sulfonylurea treatment interaction); CESC cis rs7107174 1.000 rs2244508 chr11:77948515 T/A cg02023728 chr11:77925099 USP35 0.47 6.3 0.36 1.24e-9 Testicular germ cell tumor; CESC cis rs4906332 0.782 rs7161305 chr14:104002234 G/A cg04998671 chr14:104000505 TRMT61A -0.46 -5.37 -0.31 1.73e-7 Coronary artery disease; CESC cis rs5769765 0.773 rs11090920 chr22:50320105 A/G cg02269571 chr22:50332266 NA -0.62 -6.79 -0.39 7.14e-11 Schizophrenia; CESC cis rs72781680 0.611 rs72783636 chr2:24328706 C/T cg20701182 chr2:24300061 SF3B14 0.92 10.55 0.54 6.09e-22 Lymphocyte counts; CESC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.51 -6.94 -0.39 2.95e-11 Lymphocyte counts; CESC cis rs7264396 0.747 rs2425112 chr20:34319775 A/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.61 0.42 4.76e-13 Total cholesterol levels; CESC cis rs9814567 1.000 rs7645295 chr3:134307734 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.41 -5.47 -0.32 1.02e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs17376456 0.825 rs67328989 chr5:93243133 T/A cg21475434 chr5:93447410 FAM172A 0.73 6.04 0.35 5.29e-9 Diabetic retinopathy; CESC cis rs7208859 0.623 rs170051 chr17:28914153 G/A cg14008862 chr17:28927542 LRRC37B2 0.76 5.68 0.33 3.49e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg25204440 chr1:209979598 IRF6 0.65 6.71 0.38 1.21e-10 Cleft lip with or without cleft palate; CESC cis rs3617 0.625 rs6445541 chr3:52880128 G/T cg07507251 chr3:52567010 NT5DC2 0.32 5.62 0.33 4.78e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs4144743 1.000 rs4144745 chr17:45323349 T/C cg18085866 chr17:45331354 ITGB3 -0.66 -7.64 -0.43 3.87e-13 Body mass index; CESC cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg11742103 chr11:62369870 EML3;MTA2 0.65 9.83 0.52 1.21e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1707322 1.000 rs11211200 chr1:46288352 A/G cg05343316 chr1:45956843 TESK2 0.42 5.27 0.31 2.83e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2735413 0.874 rs12917942 chr16:78064220 T/G cg04733911 chr16:78082701 NA -0.48 -7.62 -0.42 4.38e-13 Systolic blood pressure (alcohol consumption interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23260255 chr3:187871479 LPP -0.49 -6.54 -0.37 3.13e-10 Height; CESC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg22920501 chr2:26401640 FAM59B -0.86 -9.93 -0.52 5.84e-20 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11817910 chr12:31944836 H3F3C -0.71 -8.73 -0.47 2.81e-16 Gut microbiome composition (summer); CESC cis rs8099014 0.861 rs17669 chr18:56118493 C/T cg19312305 chr18:56117016 MIR122 -0.26 -5.21 -0.3 3.85e-7 Platelet count; CESC cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg13902645 chr11:5959945 NA -0.64 -7.7 -0.43 2.65e-13 DNA methylation (variation); CESC cis rs34172651 0.617 rs9922436 chr16:24704490 C/G cg06505273 chr16:24850292 NA 0.43 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC cis rs1348850 0.958 rs12471741 chr2:178448196 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 8.24 0.45 7.83e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1003719 0.553 rs1063948 chr21:38574674 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.58e-15 Eye color traits; CESC cis rs25645 0.760 rs11870683 chr17:38129841 T/A cg17344932 chr17:38183730 MED24;SNORD124 0.53 7.46 0.42 1.27e-12 Myeloid white cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03622875 chr16:50187540 PAPD5 0.56 6.39 0.37 7.32e-10 Gut microbiome composition (summer); CESC cis rs1538970 0.924 rs4660858 chr1:45936351 G/A cg24296786 chr1:45957014 TESK2 -0.45 -5.1 -0.3 6.6e-7 Platelet count; CESC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg27532560 chr4:187881888 NA -0.4 -6.14 -0.35 3e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs1355223 0.867 rs7943755 chr11:34691451 C/T cg11058730 chr11:34937778 PDHX;APIP -0.51 -6.61 -0.38 2.15e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2228479 0.850 rs62056066 chr16:89906563 G/A cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs7586673 0.893 rs889925 chr2:161971597 T/C cg08807892 chr2:162101083 NA 0.46 6.27 0.36 1.48e-9 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.74 -10.62 -0.55 3.56e-22 Prudent dietary pattern; CESC cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg03433033 chr1:76189801 ACADM 0.7 9.38 0.5 2.99e-18 Blood metabolite levels;Acylcarnitine levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg15045943 chr5:171614719 STK10 -0.47 -6.26 -0.36 1.55e-9 Height; CESC cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg25405998 chr7:65216604 CCT6P1 -0.49 -5.39 -0.31 1.57e-7 Aortic root size; CESC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg23161317 chr6:28129485 ZNF389 0.52 6.46 0.37 5.08e-10 Depression; CESC cis rs9815354 0.812 rs73071307 chr3:41798699 T/C cg03022575 chr3:42003672 ULK4 0.72 6.35 0.36 9.12e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs208520 0.690 rs207119 chr6:66786408 C/T cg07460842 chr6:66804631 NA -1.0 -13.33 -0.63 2.21e-31 Exhaled nitric oxide output; CESC cis rs7937682 0.632 rs2070894 chr11:111780837 G/A cg09085632 chr11:111637200 PPP2R1B 0.88 11.23 0.57 3.51e-24 Primary sclerosing cholangitis; CESC cis rs2730245 0.550 rs2657364 chr7:158683825 T/C cg01943577 chr7:158741284 NA -0.47 -6.2 -0.36 2.1e-9 Height; CESC cis rs2354432 0.607 rs9661159 chr1:146757923 G/A cg25205988 chr1:146714368 CHD1L -0.92 -7.89 -0.44 7.91e-14 Mitochondrial DNA levels; CESC cis rs2455799 0.613 rs12637353 chr3:15831525 T/C cg16303742 chr3:15540471 COLQ -0.37 -5.55 -0.32 7.01e-8 Mean platelet volume; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00371891 chr19:4723959 DPP9 -0.45 -6.13 -0.35 3.11e-9 Height; CESC cis rs2295499 0.754 rs35679952 chr4:2619709 G/A cg27239842 chr4:2403781 ZFYVE28 0.33 5.53 0.32 7.8e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg03433033 chr1:76189801 ACADM 0.65 7.67 0.43 3.3e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs143626010 1 rs143626010 chr16:28539398 GTGTA/G cg07382826 chr16:28625726 SULT1A1 0.39 6.49 0.37 4.29e-10 Mosquito bite size; CESC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg07701084 chr6:150067640 NUP43 0.42 5.74 0.33 2.61e-8 Lung cancer; CESC cis rs6088590 0.931 rs6088624 chr20:33436852 T/A cg08999081 chr20:33150536 PIGU 0.57 8.8 0.48 1.8e-16 Coronary artery disease; CESC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg27170947 chr2:26402098 FAM59B -0.72 -8.36 -0.46 3.48e-15 Gut microbiome composition (summer); CESC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg22920501 chr2:26401640 FAM59B 0.83 9.89 0.52 8.05e-20 Gut microbiome composition (summer); CESC cis rs10242455 0.702 rs28753399 chr7:98997259 C/T cg25640893 chr7:99214727 ZNF498 1.07 6.65 0.38 1.68e-10 Blood metabolite levels; CESC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg18769074 chr3:133464867 TF 0.33 5.67 0.33 3.73e-8 Iron status biomarkers; CESC cis rs2742234 0.541 rs11238490 chr10:43747598 G/A cg07801480 chr10:43725741 RASGEF1A -0.4 -5.09 -0.3 6.78e-7 Hirschsprung disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07352798 chr5:141488591 NDFIP1 0.6 7.6 0.42 5.12e-13 Gut microbiome composition (summer); CESC cis rs193541 0.632 rs400207 chr5:122318497 C/T cg19412675 chr5:122181750 SNX24 -0.46 -5.39 -0.31 1.58e-7 Glucose homeostasis traits; CESC cis rs7666738 0.677 rs13120306 chr4:99036099 A/T cg03467027 chr4:99064603 C4orf37 0.48 5.92 0.34 9.73e-9 Colonoscopy-negative controls vs population controls; CESC cis rs11625487 0.957 rs7156032 chr14:77951364 G/A cg20045696 chr14:77926864 AHSA1 -0.7 -7.57 -0.42 6.39e-13 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs1062177 0.724 rs2915828 chr5:151118121 G/A cg00977110 chr5:151150581 G3BP1 -0.6 -6.17 -0.35 2.52e-9 Preschool internalizing problems; CESC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg02034447 chr16:89574710 SPG7 0.56 7.46 0.42 1.24e-12 Multiple myeloma (IgH translocation); CESC cis rs10883723 0.810 rs2296590 chr10:104262628 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Allergic disease (asthma, hay fever or eczema); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg21511036 chr2:227663538 IRS1 0.44 6.1 0.35 3.78e-9 Systemic lupus erythematosus; CESC cis rs7296418 0.961 rs4275659 chr12:123447928 C/T cg05973401 chr12:123451056 ABCB9 -0.58 -7.56 -0.42 6.64e-13 Platelet count; CESC cis rs17345786 0.861 rs79181492 chr3:101216021 G/A cg11279151 chr3:101281821 RG9MTD1 -0.51 -5.67 -0.33 3.71e-8 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05826458 chr2:111875031 ACOXL 0.39 6.07 0.35 4.49e-9 Gut microbiota (bacterial taxa); CESC cis rs9309473 0.898 rs11126403 chr2:73796923 A/G cg20560298 chr2:73613845 ALMS1 -0.48 -6.51 -0.37 3.74e-10 Metabolite levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25312474 chr6:142468512 VTA1 -0.53 -7.0 -0.4 2.1e-11 Ulcerative colitis; CESC cis rs7208859 0.623 rs7219712 chr17:29080570 G/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2836633 0.929 rs4143428 chr21:40030582 G/T cg05519781 chr21:40033154 ERG 0.79 13.49 0.64 6.12e-32 Coronary artery disease; CESC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg26335602 chr6:28129616 ZNF389 0.53 7.09 0.4 1.19e-11 Depression; CESC cis rs703842 1.000 rs703842 chr12:58162739 C/T cg04478727 chr12:58166393 METTL1;FAM119B -0.68 -8.89 -0.48 9.91e-17 Multiple sclerosis; CESC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs62432291 0.681 rs404435 chr6:159654487 G/T cg14500486 chr6:159655392 FNDC1 -0.61 -6.12 -0.35 3.29e-9 Joint mobility (Beighton score); CESC cis rs17384381 1.000 rs12138852 chr1:85878208 C/T cg16011679 chr1:85725395 C1orf52 0.76 7.79 0.43 1.51e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs963731 0.649 rs1454221 chr2:39215672 C/T cg04010122 chr2:39346883 SOS1 -0.7 -5.22 -0.31 3.64e-7 Corticobasal degeneration; CESC cis rs7017914 0.967 rs13254801 chr8:71688984 T/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs9926296 0.581 rs12598477 chr16:89902482 T/C cg27121462 chr16:89883253 FANCA 0.62 7.48 0.42 1.11e-12 Vitiligo; CESC cis rs6060717 0.536 rs6060704 chr20:34530270 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.58 0.32 5.82e-8 Hip circumference adjusted for BMI; CESC cis rs116095464 0.614 rs28736753 chr5:274081 G/A cg22496380 chr5:211416 CCDC127 -0.7 -7.73 -0.43 2.21e-13 Breast cancer; CESC cis rs2933343 0.729 rs789224 chr3:128598231 A/C cg24203234 chr3:128598194 ACAD9 0.44 5.9 0.34 1.09e-8 IgG glycosylation; CESC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg15320075 chr8:145703422 NA 0.63 8.75 0.47 2.46e-16 Age at first birth; CESC cis rs6991838 0.584 rs4388482 chr8:66496203 T/G cg13398993 chr8:66546079 ARMC1 -0.48 -5.74 -0.33 2.62e-8 Intelligence (multi-trait analysis); CESC cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg20135002 chr11:47629003 NA -0.39 -5.03 -0.3 9.04e-7 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00320862 chr3:170588302 RPL22L1 0.58 6.71 0.38 1.14e-10 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg23018236 chr17:30244563 NA -0.52 -5.59 -0.32 5.57e-8 Hip circumference adjusted for BMI; CESC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg14893161 chr1:205819251 PM20D1 0.45 6.38 0.37 7.65e-10 Menarche (age at onset); CESC cis rs1395 0.778 rs11126918 chr2:27438710 G/A cg22903471 chr2:27725779 GCKR -0.41 -5.07 -0.3 7.39e-7 Blood metabolite levels; CESC cis rs6088813 1.000 rs6088823 chr20:33994265 G/T cg14752227 chr20:34000481 UQCC -0.4 -5.08 -0.3 7.17e-7 Height; CESC cis rs17384381 0.953 rs11161597 chr1:85784936 G/A cg16011679 chr1:85725395 C1orf52 0.78 7.93 0.44 6.03e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs7586673 0.857 rs16845580 chr2:161920884 T/C cg16506815 chr2:162101123 NA 0.43 5.89 0.34 1.16e-8 Intelligence (multi-trait analysis); CESC cis rs8114671 0.562 rs6120763 chr20:33506400 C/G cg07148914 chr20:33460835 GGT7 0.45 5.9 0.34 1.09e-8 Height; CESC cis rs9457247 0.582 rs9459855 chr6:167466150 G/T cg23791538 chr6:167370224 RNASET2 -0.52 -6.87 -0.39 4.45e-11 Crohn's disease; CESC trans rs10776614 0.799 rs7094216 chr10:49766949 A/G cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs7932354 0.710 rs2306032 chr11:46897253 G/C cg25783544 chr11:47291846 MADD -0.39 -5.03 -0.3 8.94e-7 Bone mineral density (hip);Bone mineral density; CESC cis rs57506017 0.585 rs1468803 chr7:12275675 A/C cg23422036 chr7:12250390 TMEM106B 0.39 5.24 0.31 3.34e-7 Neuroticism; CESC cis rs7918232 0.941 rs1753413 chr10:27397112 T/C cg14442939 chr10:27389572 ANKRD26 0.68 6.36 0.36 8.89e-10 Breast cancer; CESC cis rs9584850 0.874 rs9168 chr13:99101583 C/A cg20750642 chr13:99100586 FARP1 -0.4 -5.92 -0.34 9.74e-9 Neuroticism; CESC cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg11752832 chr7:134001865 SLC35B4 0.52 6.69 0.38 1.33e-10 Mean platelet volume; CESC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg11644478 chr21:40555479 PSMG1 1.04 17.66 0.74 1.16e-46 Cognitive function; CESC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.05 0.59 5.97e-27 Alzheimer's disease; CESC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg24675658 chr1:53192096 ZYG11B 0.54 7.49 0.42 1.05e-12 Monocyte count; CESC cis rs7917772 0.582 rs3936017 chr10:104354424 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.63 0.33 4.48e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs8070740 0.617 rs1058117 chr17:5323206 T/G cg25236894 chr17:5323110 RPAIN;NUP88 0.54 7.29 0.41 3.59e-12 Menopause (age at onset); CESC cis rs6088580 0.634 rs6087588 chr20:33066369 T/C cg24642439 chr20:33292090 TP53INP2 0.51 6.72 0.38 1.12e-10 Glomerular filtration rate (creatinine); CESC cis rs854765 0.964 rs854762 chr17:18009102 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.48 -6.29 -0.36 1.27e-9 Total body bone mineral density; CESC cis rs1707322 1.000 rs10890365 chr1:46359348 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.73 0.33 2.78e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4253772 0.637 rs9627402 chr22:46702586 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.65 5.89 0.34 1.16e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs2213920 0.516 rs71505548 chr9:118169753 G/A cg13918206 chr9:118159781 DEC1 -0.67 -5.5 -0.32 8.77e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CESC cis rs9815354 0.812 rs73073371 chr3:41843443 A/G cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs5758659 0.714 rs7245 chr22:42481849 G/A cg19513890 chr22:42538836 CYP2D7P1 0.38 5.55 0.32 6.79e-8 Cognitive function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24833071 chr7:75115655 POM121C 0.46 6.1 0.35 3.74e-9 Gut microbiota (bacterial taxa); CESC cis rs9291683 0.595 rs11731110 chr4:10037346 T/C cg02734326 chr4:10020555 SLC2A9 0.49 6.83 0.39 5.64e-11 Bone mineral density; CESC cis rs5769765 0.954 rs5770739 chr22:50268014 C/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg22823121 chr1:150693482 HORMAD1 0.47 6.89 0.39 4.04e-11 Tonsillectomy; CESC cis rs72627123 0.867 rs112965033 chr14:74461117 T/A cg08255017 chr14:74727001 VSX2 0.61 5.06 0.3 7.74e-7 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05644321 chr20:20693493 RALGAPA2 -0.65 -8.13 -0.45 1.67e-14 Gut microbiome composition (summer); CESC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.02 0.52 2.97e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11235843 0.516 rs666839 chr11:73346041 A/G cg19180555 chr12:5982295 ANO2 -0.44 -6.18 -0.35 2.34e-9 Hand grip strength; CESC cis rs12136530 0.774 rs12137160 chr1:19763379 C/T cg01832549 chr1:19774989 CAPZB -0.43 -6.15 -0.35 2.88e-9 Lead levels in blood; CESC trans rs11098499 0.754 rs1849457 chr4:120254355 A/G cg25214090 chr10:38739885 LOC399744 0.63 8.75 0.47 2.48e-16 Corneal astigmatism; CESC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg12667521 chr19:29218732 NA 0.48 6.28 0.36 1.37e-9 Methadone dose in opioid dependence; CESC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg12463550 chr7:65579703 CRCP 0.56 7.07 0.4 1.39e-11 Aortic root size; CESC cis rs4481887 1.000 rs10888356 chr1:248465044 C/T cg00666640 chr1:248458726 OR2T12 -0.36 -5.82 -0.34 1.72e-8 Common traits (Other); CESC trans rs10820912 0.673 rs75401888 chr9:92883308 C/G cg23943268 chr13:33589621 KL -0.48 -6.0 -0.35 6.55e-9 Left atrial antero-posterior diameter; CESC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg00129232 chr17:37814104 STARD3 0.57 7.67 0.43 3.29e-13 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg26338869 chr17:61819248 STRADA 0.68 8.79 0.48 1.94e-16 Prudent dietary pattern; CESC cis rs2294693 0.947 rs9369254 chr6:40989408 T/C cg14418226 chr6:40996092 UNC5CL 0.52 6.47 0.37 4.68e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg03188948 chr7:1209495 NA 0.6 6.76 0.38 8.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs13395018 0.892 rs6730556 chr2:170947722 C/G cg09813610 chr5:3601357 IRX1 -0.56 -6.0 -0.35 6.55e-9 Pulse pressure; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg27284088 chr4:84031130 PLAC8 -0.51 -6.88 -0.39 4.39e-11 Height; CESC cis rs2404602 0.608 rs12911035 chr15:76606591 T/C cg05617483 chr15:76483344 C15orf27 0.39 5.17 0.3 4.51e-7 Blood metabolite levels; CESC cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg24110177 chr3:50126178 RBM5 0.53 7.3 0.41 3.38e-12 Intelligence (multi-trait analysis); CESC cis rs826838 1.000 rs11610522 chr12:38687575 C/T cg13010199 chr12:38710504 ALG10B 0.63 8.85 0.48 1.29e-16 Heart rate; CESC cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9300255 0.537 rs2682429 chr12:123642955 C/G cg05973401 chr12:123451056 ABCB9 0.5 5.81 0.34 1.79e-8 Neutrophil percentage of white cells; CESC trans rs7246760 0.867 rs8107594 chr19:9835957 G/C cg02900749 chr2:68251473 NA -0.85 -7.44 -0.42 1.38e-12 Pursuit maintenance gain; CESC cis rs2485892 0.553 rs2494191 chr1:210346053 G/C cg23283495 chr1:209979779 IRF6 0.46 5.61 0.33 5.16e-8 Manic episodes in bipolar disorder; CESC cis rs1018836 0.892 rs7819519 chr8:91565504 C/T cg16814680 chr8:91681699 NA -0.6 -8.37 -0.46 3.34e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08974966 chr11:3078805 CARS 0.61 7.2 0.4 6.22e-12 Gut microbiome composition (summer); CESC cis rs16867321 0.950 rs1919155 chr2:181457053 T/C cg23363182 chr2:181467187 NA -0.44 -5.46 -0.32 1.1e-7 Obesity; CESC cis rs60843830 1.000 rs62114505 chr2:242426 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.12 0.53 1.47e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs921968 0.541 rs55996799 chr2:219558193 C/G cg02176678 chr2:219576539 TTLL4 -0.59 -10.36 -0.54 2.52e-21 Mean corpuscular hemoglobin concentration; CESC cis rs881375 0.678 rs10760128 chr9:123696325 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.44 6.35 0.36 9.27e-10 Rheumatoid arthritis; CESC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg03188948 chr7:1209495 NA 0.73 7.17 0.4 7.66e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14230542 chr1:110577941 FAM40A -0.42 -6.01 -0.35 6.08e-9 Gambling; CESC cis rs1355223 1.000 rs1396879 chr11:34766653 A/C cg11058730 chr11:34937778 PDHX;APIP -0.45 -5.9 -0.34 1.11e-8 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs1784581 0.588 rs9355971 chr6:162421242 A/G cg17173639 chr6:162384350 PARK2 0.58 8.89 0.48 9.87e-17 Itch intensity from mosquito bite; CESC cis rs2991971 0.967 rs12743512 chr1:45954033 A/G cg24296786 chr1:45957014 TESK2 -0.67 -9.33 -0.5 4.34e-18 High light scatter reticulocyte count; CESC cis rs72792276 0.908 rs10478797 chr5:127442066 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.64 5.77 0.33 2.25e-8 Red cell distribution width; CESC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg02725872 chr8:58115012 NA -0.38 -5.03 -0.3 8.86e-7 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -6.93 -0.39 3.13e-11 Bipolar disorder; CESC cis rs7084402 0.534 rs7911971 chr10:60305160 G/A cg07615347 chr10:60278583 BICC1 -0.57 -8.14 -0.45 1.58e-14 Refractive error; CESC cis rs1580019 0.885 rs1610141 chr7:32498435 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.42 5.07 0.3 7.45e-7 Cognitive ability; CESC cis rs11252926 0.550 rs10904148 chr10:454551 G/T cg18196295 chr10:418757 DIP2C 0.52 7.06 0.4 1.49e-11 Psychosis in Alzheimer's disease; CESC cis rs6598955 0.724 rs12754536 chr1:26639605 T/C cg19743891 chr1:26644573 UBXN11;CD52 -0.26 -5.03 -0.3 9.2e-7 Obesity-related traits; CESC cis rs9486715 0.867 rs9486181 chr6:96868132 G/A cg18709589 chr6:96969512 KIAA0776 0.45 6.46 0.37 5.05e-10 Headache; CESC cis rs1878931 0.580 rs4578649 chr16:3407258 C/T cg22508957 chr16:3507546 NAT15 0.34 5.05 0.3 8.11e-7 Body mass index (adult); CESC cis rs6570726 0.935 rs428659 chr6:145827039 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7674212 0.510 rs6856593 chr4:104177699 T/C cg16532752 chr4:104119610 CENPE -0.43 -5.89 -0.34 1.16e-8 Type 2 diabetes; CESC cis rs2880765 0.835 rs4360874 chr15:86040820 A/T cg19183879 chr15:85880815 NA -0.26 -5.34 -0.31 2.01e-7 Coronary artery disease; CESC cis rs4144743 1.000 rs67080286 chr17:45322248 T/G cg18085866 chr17:45331354 ITGB3 -0.64 -7.03 -0.4 1.78e-11 Body mass index; CESC cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg08999081 chr20:33150536 PIGU 0.53 7.95 0.44 5.51e-14 Coronary artery disease; CESC cis rs287982 0.611 rs115657324 chr2:9983856 A/G cg10881225 chr2:9984929 TAF1B 0.68 5.39 0.31 1.53e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7845219 0.544 rs7016078 chr8:95922615 G/A cg09323728 chr8:95962352 TP53INP1 -0.34 -6.76 -0.38 8.55e-11 Type 2 diabetes; CESC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg10150615 chr22:24372951 LOC391322 0.56 7.7 0.43 2.76e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg26314531 chr2:26401878 FAM59B -0.62 -6.99 -0.39 2.29e-11 Gut microbiome composition (summer); CESC cis rs6088580 0.609 rs6058029 chr20:32969643 T/C cg08999081 chr20:33150536 PIGU -0.66 -11.72 -0.58 8.03e-26 Glomerular filtration rate (creatinine); CESC cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 5.08 0.3 7.22e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs17376456 0.877 rs10044066 chr5:93437580 T/C cg25358565 chr5:93447407 FAM172A 1.13 11.5 0.58 4.18e-25 Diabetic retinopathy; CESC cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4319547 0.695 rs4758648 chr12:122900460 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -6.15 -0.35 2.82e-9 Body mass index; CESC cis rs7923609 0.967 rs7920058 chr10:65293924 T/G cg01631684 chr10:65280961 REEP3 -0.43 -5.44 -0.32 1.2e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16937126 chr8:38088972 DDHD2 0.48 6.25 0.36 1.61e-9 Systemic lupus erythematosus; CESC cis rs9815354 0.680 rs78402272 chr3:42028425 G/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16383001 chr1:100435543 SLC35A3 0.49 6.02 0.35 5.69e-9 Gut microbiome composition (summer); CESC cis rs3820068 0.608 rs6668919 chr1:16049893 A/G cg13390004 chr1:15929781 NA -0.34 -5.29 -0.31 2.53e-7 Systolic blood pressure; CESC cis rs1062177 1.000 rs1062177 chr5:151184701 C/T cg12924095 chr5:151150029 G3BP1 0.49 6.5 0.37 3.86e-10 Preschool internalizing problems; CESC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg07414643 chr4:187882934 NA 0.57 8.18 0.45 1.2e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs7916697 0.891 rs7897809 chr10:70000293 A/G cg06988349 chr10:69991859 ATOH7 0.38 6.46 0.37 5.12e-10 Optic disc area; CESC cis rs55794721 0.509 rs909834 chr1:25757996 A/G cg27572855 chr1:25598939 RHD 0.47 7.74 0.43 2.16e-13 Plateletcrit;Mean corpuscular volume; CESC cis rs290268 1.000 rs290268 chr9:93552450 A/G cg02608019 chr9:93564028 SYK 0.64 9.42 0.5 2.31e-18 Platelet count; CESC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg06873352 chr17:61820015 STRADA 0.73 12.98 0.62 3.9e-30 Prudent dietary pattern; CESC cis rs807669 0.505 rs2236759 chr22:19187427 C/G cg02655711 chr22:19163373 SLC25A1 0.43 6.45 0.37 5.25e-10 Metabolite levels; CESC cis rs1215050 0.791 rs6532702 chr4:98766641 C/T cg05340658 chr4:99064831 C4orf37 0.51 6.58 0.37 2.52e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.42 -0.37 6.22e-10 Depression; CESC cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg21881798 chr11:8931708 C11orf17;ST5 0.39 6.12 0.35 3.36e-9 Hemoglobin concentration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21933743 chr11:65367160 MAP3K11 0.42 6.17 0.35 2.48e-9 Fibrinogen levels; CESC cis rs6690583 0.623 rs7522239 chr1:85484366 C/T cg22153463 chr1:85462885 MCOLN2 0.75 7.59 0.42 5.63e-13 Serum sulfate level; CESC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg05347473 chr6:146136440 FBXO30 -0.49 -6.29 -0.36 1.34e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg24531977 chr5:56204891 C5orf35 -0.87 -10.94 -0.56 3.15e-23 Initial pursuit acceleration; CESC trans rs941207 0.542 rs2888096 chr12:57187635 A/T cg26462586 chr2:11164677 NA 0.38 6.02 0.35 5.82e-9 Platelet count; CESC cis rs11098499 0.863 rs13140409 chr4:120503460 A/G cg09307838 chr4:120376055 NA 0.95 12.98 0.62 3.72e-30 Corneal astigmatism; CESC cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg10523679 chr1:76189770 ACADM 0.75 10.09 0.53 1.8e-20 Blood metabolite levels;Acylcarnitine levels; CESC trans rs7824557 0.524 rs7835318 chr8:10953874 G/A cg15556689 chr8:8085844 FLJ10661 -0.5 -6.17 -0.35 2.58e-9 Retinal vascular caliber; CESC trans rs804280 0.542 rs34117651 chr8:11791617 G/C cg15556689 chr8:8085844 FLJ10661 0.52 6.36 0.36 8.65e-10 Myopia (pathological); CESC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.79 0.43 1.49e-13 Menopause (age at onset); CESC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg11843238 chr5:131593191 PDLIM4 0.37 5.43 0.32 1.27e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14374347 chr1:38158195 CDCA8 -0.65 -7.87 -0.44 8.94e-14 Gut microbiome composition (summer); CESC cis rs1153858 0.887 rs7171163 chr15:45636395 A/C cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg18099408 chr3:52552593 STAB1 -0.38 -6.49 -0.37 4.17e-10 Electroencephalogram traits; CESC cis rs9611565 0.512 rs45500192 chr22:42177899 A/G cg06481639 chr22:41940642 POLR3H -0.59 -5.81 -0.34 1.81e-8 Vitiligo; CESC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.64 -0.33 4.33e-8 Total body bone mineral density; CESC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg15112475 chr7:1198522 ZFAND2A -0.34 -5.5 -0.32 9.04e-8 Longevity;Endometriosis; CESC cis rs559928 0.597 rs2186572 chr11:63895887 A/G cg18225595 chr11:63971243 STIP1 0.66 5.64 0.33 4.29e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg18765753 chr7:1198926 ZFAND2A -0.5 -7.34 -0.41 2.64e-12 Longevity;Endometriosis; CESC cis rs17601876 0.814 rs28637352 chr15:51559666 C/A cg19946085 chr15:51559439 CYP19A1 -0.33 -5.37 -0.31 1.76e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs2952156 0.883 rs2941505 chr17:37832704 A/G cg07936489 chr17:37558343 FBXL20 -0.58 -7.33 -0.41 2.84e-12 Asthma; CESC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg00769240 chr8:12517080 NA -0.43 -6.04 -0.35 5.34e-9 Blood pressure (smoking interaction); CESC cis rs17253792 0.822 rs76819679 chr14:56134672 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs9911578 1.000 rs3744108 chr17:56585872 G/C cg05425664 chr17:57184151 TRIM37 0.51 7.26 0.41 4.42e-12 Intelligence (multi-trait analysis); CESC cis rs2282802 0.635 rs269767 chr5:139536922 A/G cg26211634 chr5:139558579 C5orf32 0.4 5.31 0.31 2.3e-7 Intelligence (multi-trait analysis); CESC cis rs6460942 0.555 rs7803268 chr7:12306793 G/A cg06484146 chr7:12443880 VWDE -0.78 -8.3 -0.45 5.42e-15 Coronary artery disease; CESC trans rs875971 1.000 rs4718344 chr7:65874381 C/A cg26939375 chr7:64535504 NA 0.47 6.14 0.35 3.07e-9 Aortic root size; CESC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg05863683 chr7:1912471 MAD1L1 0.38 5.85 0.34 1.42e-8 Bipolar disorder and schizophrenia; CESC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg11890956 chr21:40555474 PSMG1 1.19 22.08 0.8 5.3e-62 Cognitive function; CESC cis rs12579753 0.692 rs11115064 chr12:82278683 G/A cg21193143 chr12:82153300 PPFIA2 -0.36 -5.44 -0.32 1.18e-7 Resting heart rate; CESC cis rs6121246 0.821 rs115585940 chr20:30317902 T/C cg13852791 chr20:30311386 BCL2L1 0.79 7.36 0.41 2.36e-12 Mean corpuscular hemoglobin; CESC cis rs1707322 0.721 rs4330955 chr1:46217485 G/C cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg05340658 chr4:99064831 C4orf37 -0.64 -8.17 -0.45 1.24e-14 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09071690 chr1:59012457 OMA1 -0.45 -6.19 -0.36 2.34e-9 Fibrinogen levels; CESC trans rs7824557 0.527 rs57629785 chr8:11235150 C/A cg06636001 chr8:8085503 FLJ10661 -0.48 -6.05 -0.35 4.93e-9 Retinal vascular caliber; CESC cis rs6142102 0.649 rs4911382 chr20:32553095 C/T cg08999081 chr20:33150536 PIGU 0.34 5.1 0.3 6.63e-7 Skin pigmentation; CESC cis rs8072100 0.782 rs28507314 chr17:45551402 C/T cg25173405 chr17:45401733 C17orf57 -0.47 -6.16 -0.35 2.75e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs11098499 0.863 rs7678400 chr4:120461957 G/A cg09307838 chr4:120376055 NA 0.9 12.32 0.6 6.96e-28 Corneal astigmatism; CESC cis rs258892 0.843 rs155431 chr5:72120916 A/T cg21869765 chr5:72125136 TNPO1 -0.45 -5.72 -0.33 2.94e-8 Small cell lung carcinoma; CESC cis rs9303280 0.837 rs907092 chr17:37922259 A/G cg20243544 chr17:37824526 PNMT -0.52 -6.97 -0.39 2.53e-11 Self-reported allergy; CESC cis rs10788264 0.513 rs10749455 chr10:124035030 A/G cg09507567 chr10:124027408 NA 0.41 5.91 0.34 1.04e-8 Total body bone mineral density; CESC cis rs79518236 1 rs79518236 chr7:98026554 ACT/A cg09267113 chr7:98030324 BAIAP2L1 -0.43 -5.8 -0.34 1.89e-8 Breast cancer; CESC cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg08392591 chr16:89556376 ANKRD11 -0.42 -5.13 -0.3 5.65e-7 Multiple myeloma (IgH translocation); CESC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg17971929 chr21:40555470 PSMG1 -0.59 -7.65 -0.43 3.67e-13 Menarche (age at onset); CESC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg13880726 chr7:1868755 MAD1L1 0.53 7.16 0.4 8.13e-12 Autism spectrum disorder or schizophrenia; CESC cis rs79057730 0.527 rs34519158 chr7:811114 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.91 7.83 0.43 1.19e-13 Initial pursuit acceleration; CESC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg11764359 chr7:65958608 NA -0.79 -9.51 -0.5 1.18e-18 Aortic root size; CESC trans rs9325144 0.532 rs12812406 chr12:38719802 G/A cg23762105 chr12:34175262 ALG10 0.49 6.24 0.36 1.76e-9 Morning vs. evening chronotype; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03951724 chr22:30723125 TBC1D10A -0.47 -6.8 -0.39 6.81e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3820928 0.904 rs2217359 chr2:227759892 C/T cg11843606 chr2:227700838 RHBDD1 -0.46 -5.96 -0.34 8.02e-9 Pulmonary function; CESC cis rs6582630 0.519 rs11609739 chr12:38547969 G/A cg13010199 chr12:38710504 ALG10B 0.51 6.56 0.37 2.88e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs6088590 0.965 rs6087619 chr20:33288511 C/G cg06115741 chr20:33292138 TP53INP2 0.6 7.53 0.42 8.12e-13 Coronary artery disease; CESC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg18904891 chr8:8559673 CLDN23 -0.64 -7.17 -0.4 7.3e-12 Obesity-related traits; CESC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg17971929 chr21:40555470 PSMG1 1.06 16.34 0.71 5.24e-42 Cognitive function; CESC cis rs1808579 0.904 rs6507708 chr18:21101456 C/A cg14672496 chr18:21087552 C18orf8 0.44 6.73 0.38 1.02e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs11785400 1.000 rs7459630 chr8:143738585 A/C cg10596483 chr8:143751796 JRK 0.43 5.69 0.33 3.4e-8 Schizophrenia; CESC cis rs1707322 1.000 rs7519181 chr1:46387829 G/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7264396 0.635 rs6058378 chr20:34546658 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.57 6.83 0.39 5.63e-11 Total cholesterol levels; CESC cis rs7582720 1.000 rs72936869 chr2:203788950 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs863345 0.604 rs11265009 chr1:158498772 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.97 -0.39 2.51e-11 Pneumococcal bacteremia; CESC cis rs644799 1.000 rs1944074 chr11:95511445 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.69 0.67 3.96e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg26314531 chr2:26401878 FAM59B -0.61 -6.88 -0.39 4.31e-11 Gut microbiome composition (summer); CESC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg27165867 chr14:105738592 BRF1 -0.52 -5.59 -0.32 5.65e-8 Mean platelet volume;Platelet distribution width; CESC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.75 9.57 0.51 8.01e-19 Age-related macular degeneration (geographic atrophy); CESC trans rs1814175 0.754 rs10219245 chr11:49645052 C/T cg03929089 chr4:120376271 NA -0.94 -15.57 -0.69 2.82e-39 Height; CESC cis rs3747547 0.892 rs72726022 chr9:38019703 C/T cg13774184 chr9:37916125 SHB -0.73 -6.25 -0.36 1.61e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs5769765 0.862 rs138870 chr22:50209737 C/T cg26441486 chr22:50317300 CRELD2 0.39 5.11 0.3 6.2e-7 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03625951 chr6:149867442 PPIL4 0.5 6.46 0.37 4.86e-10 Gut microbiota (bacterial taxa); CESC cis rs13191362 0.507 rs2849518 chr6:163134248 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.59 -6.94 -0.39 2.97e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg25809561 chr17:30822961 MYO1D -0.52 -7.3 -0.41 3.37e-12 Schizophrenia; CESC cis rs7937682 0.575 rs11604704 chr11:111764396 G/A cg09085632 chr11:111637200 PPP2R1B 0.91 11.73 0.58 7.11e-26 Primary sclerosing cholangitis; CESC trans rs875971 0.660 rs7807930 chr7:66087165 C/T cg26939375 chr7:64535504 NA -0.63 -8.44 -0.46 2.1e-15 Aortic root size; CESC cis rs208520 0.526 rs7776413 chr6:66783241 A/G cg07460842 chr6:66804631 NA -1.11 -26.19 -0.85 1.74e-75 Exhaled nitric oxide output; CESC cis rs1371867 0.846 rs1660316 chr8:101333049 T/C cg11906718 chr8:101322791 RNF19A 0.53 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC cis rs4523957 0.553 rs2131703 chr17:2025360 G/T cg16513277 chr17:2031491 SMG6 -0.77 -11.28 -0.57 2.37e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs116095464 0.558 rs7710005 chr5:233572 A/G cg22496380 chr5:211416 CCDC127 -0.72 -8.27 -0.45 6.43e-15 Breast cancer; CESC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.65 0.64 1.8e-32 Prudent dietary pattern; CESC cis rs2737618 0.651 rs2249172 chr1:200082955 A/G cg21825944 chr1:200113062 NR5A2 0.41 6.4 0.37 7.08e-10 Uric acid levels; CESC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.14 -0.3 5.27e-7 Total body bone mineral density; CESC cis rs7959452 0.640 rs4761233 chr12:69722880 T/C cg14784868 chr12:69753453 YEATS4 0.73 10.42 0.54 1.53e-21 Blood protein levels; CESC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg09699651 chr6:150184138 LRP11 0.44 5.63 0.33 4.66e-8 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06371280 chr2:172017419 TLK1 -0.59 -6.52 -0.37 3.55e-10 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17098857 chr11:82556674 PRCP 0.43 6.04 0.35 5.1e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs477692 0.563 rs12266634 chr10:131412659 G/C cg24747557 chr10:131355152 MGMT 0.45 6.17 0.35 2.61e-9 Response to temozolomide; CESC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg09365446 chr1:150670422 GOLPH3L 0.4 5.38 0.31 1.61e-7 Melanoma; CESC cis rs5771069 0.931 rs5771222 chr22:50445704 C/T cg03721641 chr22:50451245 IL17REL -0.33 -5.64 -0.33 4.27e-8 Ulcerative colitis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15764058 chr3:66024691 MAGI1 -0.44 -6.23 -0.36 1.79e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9287719 0.967 rs6432126 chr2:10757101 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.67 -0.33 3.73e-8 Prostate cancer; CESC cis rs35146811 0.961 rs11771139 chr7:99736059 C/T cg22906224 chr7:99728672 NA 0.45 5.21 0.3 3.76e-7 Coronary artery disease; CESC cis rs7312933 1.000 rs11181308 chr12:42445259 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.41 5.44 0.32 1.24e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs9815354 0.812 rs10510733 chr3:42009192 T/C cg03022575 chr3:42003672 ULK4 0.69 6.24 0.36 1.72e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg18337363 chr3:52569053 NT5DC2 0.3 5.44 0.32 1.22e-7 Bipolar disorder; CESC cis rs17739794 0.557 rs7816977 chr8:814612 A/G cg01971667 chr8:817044 NA 0.28 5.16 0.3 4.77e-7 Clozapine-induced cytotoxicity; CESC cis rs7586879 0.593 rs10200566 chr2:25130462 G/T cg01884057 chr2:25150051 NA -0.4 -7.57 -0.42 6.2800000000000005e-13 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18346784 chr1:10754162 CASZ1 0.59 6.67 0.38 1.47e-10 Gut microbiome composition (summer); CESC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg03188948 chr7:1209495 NA 0.4 5.09 0.3 6.84e-7 Longevity;Endometriosis; CESC cis rs2637266 0.935 rs7909808 chr10:78392318 A/G cg18941641 chr10:78392320 NA 0.44 7.94 0.44 5.63e-14 Pulmonary function; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18030007 chr8:33370902 C8orf41 0.48 6.07 0.35 4.44e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg04267008 chr7:1944627 MAD1L1 -0.55 -6.6 -0.38 2.19e-10 Bipolar disorder and schizophrenia; CESC cis rs3806843 0.676 rs778593 chr5:140027216 T/C cg26395211 chr5:140044315 WDR55 0.51 6.48 0.37 4.45e-10 Depressive symptoms (multi-trait analysis); CESC trans rs1814175 0.765 rs1722003 chr11:49895896 G/A cg03929089 chr4:120376271 NA -0.91 -15.64 -0.69 1.68e-39 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11227645 chr1:224544764 CNIH4 0.55 6.44 0.37 5.48e-10 Gut microbiome composition (summer); CESC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.39 -5.12 -0.3 5.81e-7 Lymphocyte counts; CESC cis rs8114671 0.805 rs4616 chr20:33590358 C/T cg24642439 chr20:33292090 TP53INP2 -0.47 -5.59 -0.32 5.7e-8 Height; CESC cis rs9858542 0.953 rs3811699 chr3:49396360 T/C cg03060546 chr3:49711283 APEH -0.53 -6.05 -0.35 4.8e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2439831 0.867 rs496584 chr15:43831923 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.79 7.86 0.43 9.77e-14 Lung cancer in ever smokers; CESC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg18016565 chr1:150552671 MCL1 0.33 5.15 0.3 5.13e-7 Tonsillectomy; CESC cis rs59918340 0.764 rs4961258 chr8:142232878 A/G cg16341495 chr8:142228727 SLC45A4 0.45 5.56 0.32 6.62e-8 Immature fraction of reticulocytes; CESC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg25204440 chr1:209979598 IRF6 0.61 7.67 0.43 3.33e-13 Cleft lip with or without cleft palate; CESC cis rs10463316 0.817 rs730526 chr5:150789232 A/G cg03212797 chr5:150827313 SLC36A1 -0.42 -5.05 -0.3 8.21e-7 Metabolite levels (Pyroglutamine); CESC cis rs501120 1.000 rs915083 chr10:44755406 T/G cg09554077 chr10:44749378 NA 0.52 6.89 0.39 3.96e-11 Coronary artery disease;Coronary heart disease; CESC cis rs17376456 1.000 rs6867042 chr5:93555761 C/T cg25358565 chr5:93447407 FAM172A 1.19 10.67 0.55 2.43e-22 Diabetic retinopathy; CESC cis rs7249142 0.549 rs62135499 chr19:19294237 T/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.38 5.11 0.3 6.18e-7 IgG glycosylation; CESC cis rs2280018 0.526 rs2941257 chr16:15166445 T/C cg07549590 chr16:15018862 NA -0.61 -9.76 -0.51 2.07e-19 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs5758659 1.000 rs134873 chr22:42657566 T/G cg05082376 chr22:42548792 NA -0.38 -5.59 -0.32 5.55e-8 Cognitive function; CESC cis rs1143633 0.553 rs2723197 chr2:113689747 G/A cg12858261 chr2:113808755 IL1F8 -0.42 -5.18 -0.3 4.36e-7 Allergic disease (asthma, hay fever or eczema); CESC trans rs877282 0.898 rs10904547 chr10:766283 C/T cg22713356 chr15:30763199 NA 1.15 11.31 0.57 1.89e-24 Uric acid levels; CESC cis rs9905704 0.628 rs2531735 chr17:56551139 A/G cg12560992 chr17:57184187 TRIM37 -0.63 -5.75 -0.33 2.48e-8 Testicular germ cell tumor; CESC cis rs9796 0.870 rs8042088 chr15:41337487 C/T cg18705301 chr15:41695430 NDUFAF1 0.45 6.73 0.38 1.05e-10 Menopause (age at onset); CESC cis rs7247513 0.639 rs12984441 chr19:12760287 A/C cg23899408 chr19:12877188 HOOK2 0.43 5.31 0.31 2.34e-7 Bipolar disorder; CESC cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg05340658 chr4:99064831 C4orf37 0.78 11.87 0.59 2.5e-26 Colonoscopy-negative controls vs population controls; CESC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg23281280 chr6:28129359 ZNF389 0.44 6.46 0.37 4.96e-10 Cardiac Troponin-T levels; CESC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg27121462 chr16:89883253 FANCA -0.49 -5.74 -0.33 2.61e-8 Vitiligo; CESC cis rs7264396 0.790 rs6058293 chr20:34248891 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 3.14e-26 Total cholesterol levels; CESC cis rs11758351 0.929 rs6906367 chr6:26187125 C/T cg01420254 chr6:26195488 NA 0.55 6.43 0.37 5.88e-10 Gout;Renal underexcretion gout; CESC cis rs9818758 0.556 rs13086240 chr3:49001409 G/A cg00383909 chr3:49044727 WDR6 0.95 6.66 0.38 1.59e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs7833986 0.501 rs72653948 chr8:56955689 A/G cg26371346 chr8:56986568 SNORD54;RPS20 0.58 5.3 0.31 2.38e-7 Height; CESC cis rs6963495 0.745 rs73192150 chr7:105211610 A/C cg13798780 chr7:105162888 PUS7 0.77 7.56 0.42 6.63e-13 Bipolar disorder (body mass index interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07142678 chr1:112162349 RAP1A 0.59 6.42 0.37 6.15e-10 Gut microbiome composition (summer); CESC cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg03264133 chr6:25882463 NA -0.66 -9.71 -0.51 2.79e-19 Intelligence (multi-trait analysis); CESC cis rs3806843 0.966 rs10053945 chr5:140160127 C/T cg26395211 chr5:140044315 WDR55 -0.42 -5.31 -0.31 2.31e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg17211192 chr8:82754475 SNX16 -0.58 -7.62 -0.42 4.64e-13 Diastolic blood pressure; CESC cis rs9894429 0.690 rs11869779 chr17:79570067 C/T cg21984481 chr17:79567631 NPLOC4 0.57 9.4 0.5 2.72e-18 Eye color traits; CESC cis rs2288073 0.965 rs6545338 chr2:24422156 C/T cg06627628 chr2:24431161 ITSN2 -0.78 -9.27 -0.49 6.66e-18 Venous thromboembolism (SNP x SNP interaction); CESC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 5.99 0.35 6.83e-9 Intelligence (multi-trait analysis); CESC cis rs300703 0.816 rs434818 chr2:200477 G/A cg21211680 chr2:198530 NA 0.82 7.2 0.4 6.14e-12 Blood protein levels; CESC cis rs4253772 0.550 rs9615949 chr22:46722531 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 5.17 0.3 4.66e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.88 0.52 8.11e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6580649 0.941 rs1635529 chr12:48395102 T/G cg05342945 chr12:48394962 COL2A1 -0.56 -6.62 -0.38 2.02e-10 Lung cancer; CESC cis rs910316 1.000 rs7147118 chr14:75610170 G/C cg16144293 chr14:75469539 EIF2B2 -0.39 -5.03 -0.3 9.07e-7 Height; CESC cis rs4664308 0.618 rs66667042 chr2:160886703 A/C cg03641300 chr2:160917029 PLA2R1 -0.59 -8.54 -0.46 1.06e-15 Idiopathic membranous nephropathy; CESC cis rs7918232 0.882 rs10829190 chr10:27409555 C/T cg14240646 chr10:27532245 ACBD5 -0.63 -6.25 -0.36 1.59e-9 Breast cancer; CESC trans rs7089973 0.523 rs7071789 chr10:116735341 T/C cg17463145 chr7:79084011 MAGI2 0.31 6.1 0.35 3.75e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7762018 0.655 rs2184194 chr6:170148394 C/T cg05834625 chr6:170176447 C6orf70 0.65 7.17 0.4 7.57e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs28829049 0.597 rs34219832 chr1:19502432 C/T cg13387374 chr1:19411106 UBR4 0.43 5.45 0.32 1.13e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC trans rs637571 0.558 rs10896064 chr11:65641033 G/C cg17712092 chr4:129076599 LARP1B -0.7 -8.8 -0.48 1.78e-16 Eosinophil percentage of white cells; CESC cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3741151 0.773 rs73544720 chr11:73173496 A/G cg17517138 chr11:73019481 ARHGEF17 1.0 7.41 0.41 1.74e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs12618769 0.625 rs3820945 chr2:99105156 G/A cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs1878931 0.582 rs40633 chr16:3425325 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.68 -8.4 -0.46 2.77e-15 Body mass index (adult); CESC cis rs4242434 0.757 rs4872531 chr8:22529695 A/G cg03733263 chr8:22462867 KIAA1967 -0.78 -11.01 -0.56 1.83e-23 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs4803468 1.000 rs10422783 chr19:41906436 T/C cg14132834 chr19:41945861 ATP5SL -0.65 -8.13 -0.45 1.69e-14 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04460041 chr16:2293178 DCI -0.61 -6.69 -0.38 1.3e-10 Gut microbiome composition (summer); CESC cis rs6032067 0.929 rs17333381 chr20:43804919 C/T cg10761708 chr20:43804764 PI3 0.53 6.33 0.36 1.04e-9 Blood protein levels; CESC cis rs561341 0.714 rs547473 chr17:30297560 T/G cg19193384 chr17:30244184 NA -0.61 -6.41 -0.37 6.51e-10 Hip circumference adjusted for BMI; CESC cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg12193833 chr17:30244370 NA -0.79 -7.25 -0.41 4.49e-12 Hip circumference adjusted for BMI; CESC cis rs6120849 0.708 rs6087659 chr20:33606383 C/A cg06115741 chr20:33292138 TP53INP2 0.54 5.13 0.3 5.65e-7 Protein C levels; CESC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg12463550 chr7:65579703 CRCP 0.59 7.45 0.42 1.29e-12 Aortic root size; CESC cis rs2950393 0.929 rs10876916 chr12:57086512 G/A cg05584118 chr12:57595605 LRP1 -0.38 -5.41 -0.32 1.4e-7 Platelet distribution width; CESC cis rs7264396 0.563 rs2425117 chr20:34323776 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.81 0.39 6.52e-11 Total cholesterol levels; CESC cis rs752010 0.838 rs11210505 chr1:42104731 G/C cg06885757 chr1:42089581 HIVEP3 0.49 7.78 0.43 1.61e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs922692 0.744 rs1825087 chr15:79077114 A/G cg04896959 chr15:78267971 NA 0.35 5.1 0.3 6.61e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs11638352 1.000 rs1365456 chr15:44378843 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.69 -5.06 -0.3 7.71e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg11494091 chr17:61959527 GH2 0.73 12.66 0.61 4.86e-29 Prudent dietary pattern; CESC cis rs2742234 0.666 rs715106 chr10:43616751 C/A cg07801480 chr10:43725741 RASGEF1A 0.43 5.54 0.32 7.14e-8 Hirschsprung disease; CESC trans rs4077515 0.874 rs10781505 chr9:139271355 C/T cg11586158 chr1:175013920 NA 0.39 6.04 0.35 5.14e-9 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs10883723 0.810 rs10748823 chr10:104274465 C/G cg22532475 chr10:104410764 TRIM8 -0.33 -5.68 -0.33 3.5e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs9908102 0.710 rs56988654 chr17:12912635 T/G cg26162695 chr17:12921313 ELAC2 0.52 5.71 0.33 3.04e-8 Schizophrenia; CESC trans rs997295 0.529 rs12592315 chr15:68040266 A/G cg22838674 chr8:37619818 PROSC 0.47 6.02 0.35 5.88e-9 Motion sickness; CESC cis rs75804782 0.521 rs72993033 chr2:239382882 A/G cg18131467 chr2:239335373 ASB1 -0.73 -5.88 -0.34 1.23e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.6 -6.37 -0.36 8.54e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC trans rs9858542 0.953 rs35169793 chr3:49423274 A/G cg21659725 chr3:3221576 CRBN -0.54 -6.47 -0.37 4.62e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6060717 0.536 rs11699815 chr20:34543125 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.58 0.32 6e-8 Hip circumference adjusted for BMI; CESC cis rs3026101 0.671 rs3026115 chr17:5285222 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.46 6.21 0.36 2e-9 Body mass index; CESC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg17949981 chr6:28129498 ZNF389 0.45 5.71 0.33 3.07e-8 Parkinson's disease; CESC cis rs9616064 0.740 rs6520049 chr22:46996309 C/T cg05621596 chr22:47072043 GRAMD4 -0.44 -6.67 -0.38 1.5e-10 Urate levels in obese individuals; CESC cis rs17641971 0.684 rs7005693 chr8:49987965 A/C cg00325661 chr8:49890786 NA 0.39 5.5 0.32 8.94e-8 Blood metabolite levels; CESC cis rs7605827 0.930 rs11902128 chr2:15515269 T/G cg19274914 chr2:15703543 NA 0.31 5.39 0.31 1.55e-7 Educational attainment (years of education); CESC cis rs11122272 0.735 rs2486733 chr1:231531465 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs9814567 0.806 rs2888670 chr3:134326684 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.12 -0.3 5.96e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs1814175 0.616 rs1851848 chr11:49992254 G/C cg15704280 chr7:45808275 SEPT13 -1.0 -19.0 -0.76 2.19e-51 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12402495 chr1:154192844 C1orf43;UBAP2L 0.48 6.38 0.36 7.9e-10 Gut microbiota (bacterial taxa); CESC cis rs10905065 1.000 rs10737013 chr10:5746772 C/G cg11519256 chr10:5708881 ASB13 0.49 6.64 0.38 1.81e-10 Menopause (age at onset); CESC cis rs7917772 0.503 rs7893155 chr10:104294228 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.41 0.41 1.67e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9322193 0.884 rs9397036 chr6:150172923 C/T cg09699651 chr6:150184138 LRP11 0.51 6.43 0.37 5.91e-10 Lung cancer; CESC cis rs9486719 0.948 rs12203657 chr6:96883285 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg07701084 chr6:150067640 NUP43 0.46 6.45 0.37 5.26e-10 Lung cancer; CESC cis rs9388451 0.505 rs6920965 chr6:126179111 G/A cg05901451 chr6:126070800 HEY2 -0.42 -5.58 -0.32 5.99e-8 Brugada syndrome; CESC cis rs3106136 0.843 rs4282187 chr4:95273145 T/C cg11021082 chr4:95130006 SMARCAD1 0.39 5.46 0.32 1.08e-7 Capecitabine sensitivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22425913 chr8:144099991 LY6E;LOC100133669 0.61 6.84 0.39 5.44e-11 Gut microbiome composition (summer); CESC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg02951883 chr7:2050386 MAD1L1 -0.41 -5.22 -0.31 3.7e-7 Bipolar disorder and schizophrenia; CESC cis rs4332037 0.950 rs11771828 chr7:1941003 T/C cg23422044 chr7:1970798 MAD1L1 -0.53 -5.33 -0.31 2.09e-7 Bipolar disorder; CESC cis rs637571 0.522 rs493899 chr11:65747952 A/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 6.05 0.35 5.01e-9 Eosinophil percentage of white cells; CESC cis rs61931739 0.517 rs10844830 chr12:34308133 C/T cg06521331 chr12:34319734 NA -0.4 -5.55 -0.32 6.78e-8 Morning vs. evening chronotype; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17994379 chr17:43025264 KIF18B 0.48 6.15 0.35 2.79e-9 Gut microbiota (bacterial taxa); CESC cis rs7072216 0.763 rs12259939 chr10:100169021 T/C cg26618903 chr10:100175079 PYROXD2 -0.37 -5.76 -0.33 2.33e-8 Metabolite levels; CESC cis rs7772486 0.902 rs2777480 chr6:146309983 T/A cg23711669 chr6:146136114 FBXO30 0.75 10.71 0.55 1.72e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs11583043 0.575 rs56403901 chr1:101586047 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.48 5.33 0.31 2.11e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.49 -6.2 -0.36 2.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7824557 0.569 rs35418978 chr8:11186453 T/C cg21775007 chr8:11205619 TDH 0.5 7.23 0.41 5.21e-12 Retinal vascular caliber; CESC cis rs6460942 1.000 rs2033871 chr7:12405098 C/A cg13733410 chr7:12443478 VWDE -0.53 -5.33 -0.31 2.12e-7 Coronary artery disease; CESC cis rs4423214 1.000 rs12422045 chr11:71154820 C/T cg05163923 chr11:71159392 DHCR7 0.83 11.73 0.58 7.01e-26 Vitamin D levels; CESC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg09658497 chr7:2847517 GNA12 -0.38 -5.52 -0.32 8.01e-8 Height; CESC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg17143192 chr8:8559678 CLDN23 0.71 7.78 0.43 1.61e-13 Obesity-related traits; CESC cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg10523679 chr1:76189770 ACADM 0.76 10.46 0.54 1.18e-21 Blood metabolite levels;Acylcarnitine levels; CESC cis rs34311866 0.748 rs10029038 chr4:899352 T/C cg07828340 chr4:882639 GAK 1.06 7.74 0.43 2.06e-13 Parkinson's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26240532 chr19:52643172 ZNF616 -0.42 -6.16 -0.35 2.69e-9 Gambling; CESC cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg19717773 chr7:2847554 GNA12 -0.57 -9.19 -0.49 1.2e-17 Height; CESC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.96e-7 Life satisfaction; CESC cis rs477692 0.699 rs528549 chr10:131381574 A/G cg24747557 chr10:131355152 MGMT -0.37 -5.04 -0.3 8.51e-7 Response to temozolomide; CESC cis rs796364 0.951 rs10931888 chr2:201022952 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -6.95 -0.39 2.83e-11 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05065690 chr12:49246007 DDX23 -0.47 -6.75 -0.38 9.09e-11 Gambling; CESC cis rs2404602 0.655 rs8028294 chr15:77084877 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs5758659 1.000 rs5758677 chr22:42643039 A/C cg05082376 chr22:42548792 NA -0.37 -5.49 -0.32 9.45e-8 Cognitive function; CESC cis rs8177179 0.967 rs4994582 chr3:133437566 G/C cg24879335 chr3:133465180 TF 0.41 7.51 0.42 8.82e-13 Iron status biomarkers (transferrin levels); CESC cis rs2859741 0.587 rs516139 chr1:37471617 C/G cg09363841 chr1:37513479 NA -0.46 -6.38 -0.36 7.94e-10 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs12477438 0.765 rs4374423 chr2:99662348 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs4727027 0.933 rs10238826 chr7:148830888 A/G cg23158103 chr7:148848205 ZNF398 -0.4 -6.51 -0.37 3.67e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs17181170 0.500 rs12493464 chr3:87209157 A/C ch.2.199792288R chr2:200084043 NA -0.46 -6.0 -0.35 6.33e-9 Prostate cancer; CESC cis rs9560113 0.573 rs7988040 chr13:112226534 C/G cg10483660 chr13:112241077 NA 0.42 7.1 0.4 1.13e-11 Menarche (age at onset); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18551892 chr11:86667149 FZD4 0.45 6.11 0.35 3.49e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4969178 0.965 rs8071884 chr17:76398058 C/G cg20026190 chr17:76395443 PGS1 0.49 7.78 0.43 1.65e-13 HDL cholesterol levels; CESC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg12463550 chr7:65579703 CRCP 0.55 6.86 0.39 4.77e-11 Aortic root size; CESC cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg10645314 chr2:3704589 ALLC -0.46 -5.09 -0.3 6.83e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs17818399 0.890 rs34544165 chr2:46836906 A/G cg02822958 chr2:46747628 ATP6V1E2 0.45 5.61 0.33 5.14e-8 Height; CESC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.2 0.4 6.31e-12 Bipolar disorder; CESC cis rs13191362 0.935 rs34587258 chr6:162945580 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.73 6.42 0.37 6.43e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4130590 0.934 rs7041940 chr9:130109746 T/C cg13736810 chr9:130213283 LRSAM1;RPL12 0.51 6.13 0.35 3.17e-9 Bipolar disorder; CESC cis rs9611565 0.559 rs5758412 chr22:42080803 T/A cg06634786 chr22:41940651 POLR3H 0.62 6.25 0.36 1.67e-9 Vitiligo; CESC cis rs7429990 0.965 rs1013431 chr3:48029118 A/C cg11946769 chr3:48343235 NME6 -0.43 -5.2 -0.3 4e-7 Educational attainment (years of education); CESC cis rs4953318 1.000 rs4953318 chr2:46355051 A/C cg12428440 chr2:46370979 PRKCE 0.37 5.29 0.31 2.61e-7 Red blood cell count;Hematocrit;Red blood cell traits; CESC cis rs7481584 0.581 rs105686 chr11:3062467 G/A cg25174290 chr11:3078921 CARS -0.51 -7.12 -0.4 1e-11 Calcium levels; CESC cis rs6088580 0.660 rs6059893 chr20:33105897 T/G cg06115741 chr20:33292138 TP53INP2 0.44 5.69 0.33 3.34e-8 Glomerular filtration rate (creatinine); CESC cis rs1215050 0.791 rs684210 chr4:98678740 G/C cg05340658 chr4:99064831 C4orf37 0.47 6.04 0.35 5.08e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.51 0.37 3.75e-10 Prudent dietary pattern; CESC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg19318889 chr4:1322082 MAEA 0.43 5.48 0.32 9.86e-8 Longevity; CESC cis rs2933343 0.700 rs1680778 chr3:128614185 A/C cg25356066 chr3:128598488 ACAD9 0.59 7.9 0.44 7.52e-14 IgG glycosylation; CESC cis rs28829049 0.597 rs34215816 chr1:19433953 G/A cg13387374 chr1:19411106 UBR4 0.41 5.07 0.3 7.4e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs10129255 0.500 rs8004923 chr14:107194164 A/G cg07958169 chr14:107095056 NA -0.53 -8.18 -0.45 1.23e-14 Kawasaki disease; CESC cis rs1707322 1.000 rs4539075 chr1:46358010 C/T cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9309473 0.607 rs7574291 chr2:73594941 A/G cg20560298 chr2:73613845 ALMS1 -0.51 -7.2 -0.4 6.35e-12 Metabolite levels; CESC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg07677032 chr17:61819896 STRADA 0.41 5.35 0.31 1.95e-7 Prudent dietary pattern; CESC cis rs5769765 0.773 rs9616395 chr22:50317803 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.55 -5.06 -0.3 7.81e-7 Schizophrenia; CESC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg07153921 chr17:41440717 NA -0.38 -5.06 -0.3 7.75e-7 Menopause (age at onset); CESC cis rs2742234 0.554 rs1254963 chr10:43696086 C/T cg15436174 chr10:43711423 RASGEF1A 0.5 5.85 0.34 1.45e-8 Hirschsprung disease; CESC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg17971929 chr21:40555470 PSMG1 -0.6 -8.04 -0.44 2.96e-14 Menarche (age at onset); CESC cis rs1580019 0.713 rs2167274 chr7:32524844 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.36 0.36 8.68e-10 Cognitive ability; CESC cis rs9435341 0.930 rs12408634 chr1:107579540 G/A cg09367891 chr1:107599246 PRMT6 0.7 8.3 0.45 5.32e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs7173419 0.607 rs1448488 chr15:28216857 C/T cg20906524 chr15:28200668 OCA2 -0.37 -5.12 -0.3 5.98e-7 Eye color; CESC cis rs3091242 0.728 rs706845 chr1:25730713 G/A cg03538708 chr1:25844672 NA -0.4 -5.92 -0.34 1e-8 Erythrocyte sedimentation rate; CESC cis rs4319547 0.956 rs10847179 chr12:123040985 T/C cg23029597 chr12:123009494 RSRC2 -0.49 -5.32 -0.31 2.21e-7 Body mass index; CESC cis rs79349575 0.783 rs28409394 chr17:46998118 T/C cg16584676 chr17:46985605 UBE2Z 0.56 7.02 0.4 1.86e-11 Type 2 diabetes; CESC cis rs6662572 0.737 rs4660887 chr1:46275959 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.11 -0.3 6.16e-7 Blood protein levels; CESC cis rs9640161 0.659 rs11975886 chr7:150010362 G/A cg21361702 chr7:150065534 REPIN1 0.54 6.29 0.36 1.3e-9 Blood protein levels;Circulating chemerin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17014947 chr15:35529521 LOC723972 -0.66 -7.67 -0.43 3.23e-13 Gut microbiome composition (summer); CESC cis rs6120849 0.754 rs6087666 chr20:33640242 G/A cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs2249694 0.878 rs2987792 chr10:135371466 T/C cg20169779 chr10:135381914 SYCE1 0.4 5.72 0.33 2.88e-8 Obesity-related traits; CESC cis rs35306767 0.953 rs7908138 chr10:962978 C/T cg20503657 chr10:835505 NA 0.74 8.11 0.45 1.89e-14 Eosinophil percentage of granulocytes; CESC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg22823121 chr1:150693482 HORMAD1 0.47 6.49 0.37 4.09e-10 Melanoma; CESC cis rs116095464 0.558 rs10075018 chr5:239175 G/A cg20965017 chr5:231967 SDHA -0.46 -5.25 -0.31 3.06e-7 Breast cancer; CESC cis rs3931020 0.508 rs11485298 chr1:75217752 C/T cg26855724 chr1:75198818 TYW3;CRYZ 0.44 5.17 0.3 4.69e-7 Resistin levels; CESC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg25072359 chr17:41440525 NA -0.51 -7.57 -0.42 6.05e-13 Menopause (age at onset); CESC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.81 0.34 1.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9902453 1.000 rs11080114 chr17:28407287 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.64 -8.06 -0.44 2.71e-14 Coffee consumption (cups per day); CESC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg07507251 chr3:52567010 NT5DC2 0.43 7.44 0.42 1.36e-12 Bipolar disorder; CESC cis rs7666738 0.830 rs11944035 chr4:98931618 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs7851660 0.967 rs7851552 chr9:100610652 C/A cg13688889 chr9:100608707 NA -0.68 -10.64 -0.55 3.08e-22 Strep throat; CESC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.43 -0.32 1.26e-7 Life satisfaction; CESC cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg16262614 chr3:133464971 TF 0.42 8.23 0.45 8.64e-15 Iron status biomarkers (transferrin levels); CESC cis rs10504073 0.669 rs57085792 chr8:50018355 T/C cg00325661 chr8:49890786 NA 0.52 7.95 0.44 5.53e-14 Blood metabolite ratios; CESC cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg05457628 chr5:178986728 RUFY1 -0.41 -5.7 -0.33 3.11e-8 Lung cancer; CESC cis rs2072732 0.861 rs16823392 chr1:2953833 C/G cg15211996 chr1:2936768 ACTRT2 0.34 6.04 0.35 5.27e-9 Plateletcrit; CESC cis rs6964587 0.869 rs6975243 chr7:91514672 G/A cg17063962 chr7:91808500 NA -0.51 -6.84 -0.39 5.36e-11 Breast cancer; CESC cis rs6582630 0.504 rs4882367 chr12:38330878 A/T cg26384229 chr12:38710491 ALG10B -0.46 -6.0 -0.35 6.62e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs6546537 1.000 rs4286306 chr2:69885647 G/C cg10773587 chr2:69614142 GFPT1 -0.43 -5.23 -0.31 3.4e-7 Serum thyroid-stimulating hormone levels; CESC cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs524023 1.000 rs12786214 chr11:64364203 G/A cg07220939 chr11:64358617 SLC22A12 -0.36 -5.55 -0.32 6.77e-8 Urate levels in obese individuals; CESC cis rs4835473 0.897 rs11723113 chr4:144628436 C/T cg25736465 chr4:144833511 NA 0.38 5.77 0.33 2.19e-8 Immature fraction of reticulocytes; CESC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.22 0.45 9.28e-15 Menopause (age at onset); CESC cis rs6748734 0.625 rs7598309 chr2:241824876 A/T cg04034577 chr2:241836375 C2orf54 -0.29 -5.25 -0.31 3.1e-7 Urinary metabolites; CESC cis rs6582630 0.555 rs11182193 chr12:38474090 C/G cg26384229 chr12:38710491 ALG10B 0.71 10.82 0.55 7.82e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs9929218 0.954 rs9925923 chr16:68819614 C/T cg02972257 chr16:68554789 NA 0.48 5.67 0.33 3.72e-8 Colorectal cancer; CESC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg11890956 chr21:40555474 PSMG1 -0.87 -13.02 -0.62 2.65e-30 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24975666 chr17:80416629 NARF 0.59 6.79 0.38 7.15e-11 Gut microbiome composition (summer); CESC cis rs11741688 0.631 rs4444956 chr5:178325515 A/G cg20935368 chr5:178288625 ZNF354B 0.35 5.35 0.31 1.91e-7 Sleep duration; CESC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs2932538 0.922 rs3790612 chr1:113084146 G/A cg22162597 chr1:113214053 CAPZA1 0.54 6.68 0.38 1.39e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg22920501 chr2:26401640 FAM59B -0.78 -9.21 -0.49 1.03e-17 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg12193833 chr17:30244370 NA -0.72 -6.64 -0.38 1.78e-10 Hip circumference adjusted for BMI; CESC trans rs9354308 0.933 rs2802064 chr6:66564352 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 7.85 0.43 1.02e-13 Metabolite levels; CESC cis rs7829975 0.623 rs7010753 chr8:8373956 A/G cg06636001 chr8:8085503 FLJ10661 0.53 6.75 0.38 9.31e-11 Mood instability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17371350 chr17:655677 ELP2P;GEMIN4 0.55 6.62 0.38 2.01e-10 Gut microbiome composition (summer); CESC cis rs9925964 0.748 rs4889603 chr16:30982225 C/T cg02466173 chr16:30829666 NA -0.35 -5.38 -0.31 1.63e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6424115 0.830 rs3003336 chr1:24201448 C/T cg10978503 chr1:24200527 CNR2 0.33 6.64 0.38 1.73e-10 Immature fraction of reticulocytes; CESC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg17949981 chr6:28129498 ZNF389 0.42 5.26 0.31 2.96e-7 Parkinson's disease; CESC cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg10556349 chr10:835070 NA 0.56 5.38 0.31 1.63e-7 Eosinophil percentage of granulocytes; CESC cis rs5758659 0.714 rs5751220 chr22:42516205 A/C cg15557168 chr22:42548783 NA 0.48 7.42 0.41 1.62e-12 Cognitive function; CESC cis rs3820068 0.705 rs16851727 chr1:15857918 C/T cg18192808 chr1:15853278 DNAJC16 0.46 5.53 0.32 7.73e-8 Systolic blood pressure; CESC cis rs858239 0.730 rs858289 chr7:23248158 C/T cg23682824 chr7:23144976 KLHL7 0.42 5.54 0.32 7.17e-8 Cerebrospinal fluid biomarker levels; CESC cis rs4148883 0.651 rs10020052 chr4:100086331 C/G cg12011299 chr4:100065546 ADH4 0.67 9.84 0.52 1.16e-19 Alcohol dependence; CESC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.46 -6.38 -0.36 7.84e-10 Bipolar disorder; CESC cis rs2243480 1.000 rs34970380 chr7:65431493 C/T cg12463550 chr7:65579703 CRCP 0.68 5.46 0.32 1.08e-7 Diabetic kidney disease; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg12440566 chr8:37553131 ZNF703 -0.45 -6.42 -0.37 6.37e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs4843747 0.573 rs7499959 chr16:88110422 C/G cg06915872 chr16:87998081 BANP 0.44 5.38 0.31 1.67e-7 Menopause (age at onset); CESC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.63 -0.33 4.6e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg07090678 chr1:91966139 CDC7 0.42 5.71 0.33 2.97e-8 Breast cancer; CESC cis rs2180341 1.000 rs9398838 chr6:127635285 C/T cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6.31e-39 Breast cancer; CESC cis rs9837602 1.000 rs7620228 chr3:99790332 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.5 6.95 0.39 2.75e-11 Breast cancer; CESC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg27121462 chr16:89883253 FANCA 0.73 10.09 0.53 1.79e-20 Vitiligo; CESC cis rs2732480 0.577 rs2732448 chr12:48730600 T/C cg04545296 chr12:48745243 ZNF641 0.43 7.3 0.41 3.34e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs12681366 0.762 rs6997115 chr8:95365885 C/T cg13257157 chr8:95487014 RAD54B 0.4 5.48 0.32 9.97e-8 Nonsyndromic cleft lip with cleft palate; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00332575 chr22:36925175 EIF3D -0.47 -6.25 -0.36 1.65e-9 Height; CESC cis rs644799 1.000 rs693597 chr11:95589629 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.18 0.35 2.42e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs922182 0.633 rs12904468 chr15:64268890 A/T cg24729988 chr15:64271149 DAPK2 -0.46 -6.43 -0.37 6.01e-10 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26878675 chr16:88783039 FAM38A 0.43 6.03 0.35 5.42e-9 Fibrinogen levels; CESC cis rs66573146 0.572 rs68169399 chr4:6952491 T/A cg26116260 chr4:7069785 GRPEL1 -0.79 -5.25 -0.31 3.14e-7 Granulocyte percentage of myeloid white cells; CESC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg21251018 chr6:28226885 NKAPL -0.33 -5.07 -0.3 7.53e-7 Depression; CESC cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg21475434 chr5:93447410 FAM172A 0.7 6.59 0.38 2.39e-10 Diabetic retinopathy; CESC cis rs72781680 1.000 rs72781632 chr2:24198342 A/C cg20701182 chr2:24300061 SF3B14 0.79 6.83 0.39 5.75e-11 Lymphocyte counts; CESC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg08499158 chr17:42289980 UBTF -0.51 -6.38 -0.36 7.82e-10 Total body bone mineral density; CESC cis rs4330281 0.631 rs6789467 chr3:17802134 G/C cg20981856 chr3:17787350 NA 0.36 5.06 0.3 7.84e-7 Schizophrenia; CESC cis rs7772486 0.905 rs9373486 chr6:146446024 C/G cg23711669 chr6:146136114 FBXO30 -0.82 -11.9 -0.59 1.84e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs2635047 0.811 rs28471970 chr18:44788439 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.51 0.32 8.36e-8 Educational attainment; CESC cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1322639 0.614 rs7768154 chr6:169565470 A/G cg03254818 chr6:169586852 NA 0.53 5.71 0.33 3.03e-8 Pulse pressure; CESC cis rs2070997 0.607 rs4740204 chr9:133676052 T/G cg11464064 chr9:133710261 ABL1 0.64 7.6 0.42 5.21e-13 Response to amphetamines; CESC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg19099843 chr7:12443191 VWDE -0.51 -5.39 -0.31 1.59e-7 Coronary artery disease; CESC trans rs11764590 0.950 rs62444919 chr7:2109499 C/T cg11693508 chr17:37793320 STARD3 0.68 6.86 0.39 4.97e-11 Neuroticism; CESC cis rs10851478 0.657 rs12916839 chr15:49735665 C/T cg08060515 chr15:49448048 GALK2;COPS2 0.54 6.68 0.38 1.43e-10 Oral cavity cancer; CESC cis rs7590368 0.926 rs12621237 chr2:10957538 T/C cg15705551 chr2:10952987 PDIA6 0.5 5.65 0.33 4.04e-8 Educational attainment (years of education); CESC cis rs8067354 0.507 rs2645478 chr17:58014712 G/A cg13753209 chr17:57696993 CLTC 0.51 5.63 0.33 4.57e-8 Hemoglobin concentration; CESC cis rs2549003 1.000 rs2706384 chr5:131826880 G/T cg21138405 chr5:131827807 IRF1 -0.6 -10.77 -0.55 1.14e-22 Asthma (sex interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07252851 chr5:74063056 GFM2;NSA2 0.61 7.14 0.4 8.96e-12 Gut microbiome composition (summer); CESC cis rs4906332 0.811 rs2021965 chr14:103997248 C/A cg19000871 chr14:103996768 TRMT61A 0.36 5.34 0.31 2e-7 Coronary artery disease; CESC trans rs12681287 0.547 rs56752411 chr8:87515156 C/T cg27317242 chr8:23145699 R3HCC1 -0.51 -6.05 -0.35 4.96e-9 Caudate activity during reward; CESC cis rs2455799 0.613 rs13078485 chr3:15883236 T/C cg16303742 chr3:15540471 COLQ -0.36 -5.42 -0.32 1.32e-7 Mean platelet volume; CESC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.56 0.47 9.4e-16 Bipolar disorder; CESC cis rs35110281 0.659 rs73367822 chr21:45024252 C/T cg01579765 chr21:45077557 HSF2BP -0.57 -9.74 -0.51 2.4e-19 Mean corpuscular volume; CESC cis rs751837 0.591 rs10135200 chr14:103411004 A/G cg10087771 chr14:103399429 CDC42BPB 0.64 5.74 0.33 2.57e-8 Large B-cell lymphoma; CESC cis rs9910055 0.529 rs850851 chr17:42177674 C/T cg19774624 chr17:42201019 HDAC5 0.56 7.43 0.42 1.49e-12 Total body bone mineral density; CESC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg00475322 chr7:917719 C7orf20 0.46 5.1 0.3 6.53e-7 Cerebrospinal P-tau181p levels; CESC cis rs4835473 0.932 rs1828502 chr4:144906950 C/G cg25736465 chr4:144833511 NA 0.41 6.29 0.36 1.28e-9 Immature fraction of reticulocytes; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg08850400 chr17:18231786 SHMT1 -0.44 -6.07 -0.35 4.3e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs425277 0.527 rs3107144 chr1:2045380 C/A cg04315214 chr1:2043799 PRKCZ 0.62 11.23 0.57 3.43e-24 Height; CESC cis rs7927771 1.000 rs12421210 chr11:47779586 C/T cg05585544 chr11:47624801 NA -0.51 -7.89 -0.44 8.01e-14 Subjective well-being; CESC cis rs11785400 0.753 rs9773415 chr8:143731170 G/A cg10596483 chr8:143751796 JRK 0.42 5.24 0.31 3.25e-7 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15605888 chr2:109403293 CCDC138 0.46 6.26 0.36 1.51e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg04315214 chr1:2043799 PRKCZ -0.45 -7.3 -0.41 3.26e-12 Height; CESC cis rs8114671 0.562 rs2378294 chr20:33500378 G/A cg24642439 chr20:33292090 TP53INP2 0.44 5.26 0.31 2.98e-7 Height; CESC cis rs72901758 0.662 rs56326958 chr17:76250439 C/G cg26068271 chr17:76253126 NA 0.46 6.6 0.38 2.25e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs9388451 0.531 rs9375414 chr6:126154475 G/A cg05901451 chr6:126070800 HEY2 -0.44 -5.89 -0.34 1.16e-8 Brugada syndrome; CESC cis rs9486719 1.000 rs9400016 chr6:96940883 G/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.48 -0.46 1.62e-15 Migraine;Coronary artery disease; CESC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.22 0.31 3.56e-7 Electroencephalogram traits; CESC cis rs1348850 0.872 rs12991272 chr2:178457339 T/C cg23306229 chr2:178417860 TTC30B 0.45 5.46 0.32 1.1e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16136840 chr5:95997740 CAST 0.69 8.17 0.45 1.25e-14 Gut microbiome composition (summer); CESC cis rs73001065 0.591 rs57009615 chr19:19613622 A/G cg03709012 chr19:19516395 GATAD2A 1.05 10.28 0.53 4.39e-21 LDL cholesterol; CESC cis rs9614461 0.702 rs3788648 chr22:45727180 G/A cg15911859 chr22:45810043 RIBC2;SMC1B 0.72 7.8 0.43 1.4e-13 Tonsillectomy; CESC cis rs524281 0.861 rs2177053 chr11:65966145 A/C cg14036092 chr11:66035641 RAB1B -0.59 -6.08 -0.35 4.11e-9 Electroencephalogram traits; CESC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg07677032 chr17:61819896 STRADA 0.46 6.17 0.35 2.57e-9 Prudent dietary pattern; CESC cis rs2742234 0.541 rs11238481 chr10:43719286 A/G cg15436174 chr10:43711423 RASGEF1A 0.47 5.58 0.32 5.81e-8 Hirschsprung disease; CESC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg05564831 chr3:52568323 NT5DC2 -0.41 -6.07 -0.35 4.31e-9 Bipolar disorder; CESC cis rs34172651 0.917 rs12923476 chr16:24798079 G/A cg06028605 chr16:24865363 SLC5A11 0.48 7.19 0.4 6.43e-12 Intelligence (multi-trait analysis); CESC cis rs6432018 1.000 rs7596929 chr2:9717645 A/T cg23886495 chr2:9695866 ADAM17 0.43 5.04 0.3 8.54e-7 Heart rate variability traits; CESC cis rs7124681 0.565 rs2203712 chr11:47534964 T/C cg20307385 chr11:47447363 PSMC3 0.64 8.77 0.47 2.17e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06988368 chr1:147142773 ACP6 0.68 7.47 0.42 1.18e-12 Gut microbiome composition (summer); CESC cis rs2880765 0.835 rs6497206 chr15:86029225 A/G cg10818794 chr15:86012489 AKAP13 -0.34 -5.33 -0.31 2.07e-7 Coronary artery disease; CESC cis rs2072732 0.861 rs34408665 chr1:2950067 A/G cg03976712 chr1:2946727 NA 0.35 5.84 0.34 1.49e-8 Plateletcrit; CESC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 10.29 0.53 4.1e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1580019 0.563 rs764483 chr7:32578150 A/T cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.96 0.76 2.97e-51 Cognitive ability; CESC cis rs2933343 1.000 rs876755 chr3:128627933 C/T cg25356066 chr3:128598488 ACAD9 0.6 7.39 0.41 1.92e-12 IgG glycosylation; CESC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg04267008 chr7:1944627 MAD1L1 -0.6 -7.33 -0.41 2.81e-12 Bipolar disorder and schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27505538 chr15:81616786 STARD5 -0.42 -6.12 -0.35 3.35e-9 Gambling; CESC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg03609598 chr5:56110824 MAP3K1 -0.51 -5.37 -0.31 1.68e-7 Initial pursuit acceleration; CESC cis rs763121 0.962 rs5757135 chr22:38952573 C/T cg06544989 chr22:39130855 UNC84B 0.46 8.43 0.46 2.19e-15 Menopause (age at onset); CESC trans rs10242455 0.702 rs73403286 chr7:99154865 A/C cg09045935 chr12:6379348 NA 0.91 6.98 0.39 2.36e-11 Blood metabolite levels; CESC cis rs1728785 0.901 rs3087783 chr16:68599668 C/T cg02972257 chr16:68554789 NA -0.68 -7.63 -0.42 4.2e-13 Ulcerative colitis; CESC cis rs10493773 0.775 rs12564080 chr1:86196586 A/C cg17807903 chr1:86174739 ZNHIT6 -0.39 -5.38 -0.31 1.64e-7 Urate levels in overweight individuals; CESC trans rs10832139 0.553 rs61884784 chr11:13947617 A/G cg11511669 chr12:131556214 GPR133 0.52 6.42 0.37 6.19e-10 P wave terminal force; CESC cis rs7605827 0.930 rs4668444 chr2:15515642 C/T cg19274914 chr2:15703543 NA 0.31 5.39 0.31 1.55e-7 Educational attainment (years of education); CESC cis rs9914988 0.832 rs35033748 chr17:27179590 T/C cg20469991 chr17:27169893 C17orf63 -0.43 -5.14 -0.3 5.43e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs7945705 0.783 rs11042125 chr11:8938049 A/T cg12365402 chr11:9010492 NRIP3 -0.39 -6.15 -0.35 2.82e-9 Hemoglobin concentration; CESC cis rs7551222 0.716 rs6679717 chr1:204560677 A/G cg20240347 chr1:204465584 NA -0.26 -5.47 -0.32 1.03e-7 Schizophrenia; CESC cis rs12887734 0.524 rs12888002 chr14:104238647 T/C cg01849466 chr14:104193079 ZFYVE21 -0.42 -5.31 -0.31 2.36e-7 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs116095464 0.558 rs9312957 chr5:202194 C/T cg22857025 chr5:266934 NA -1.25 -14.44 -0.66 2.84e-35 Breast cancer; CESC cis rs3768617 0.565 rs4652775 chr1:183061825 A/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.13 0.63 1.12e-30 Fuchs's corneal dystrophy; CESC cis rs10504073 0.647 rs9643395 chr8:50014500 A/C cg00325661 chr8:49890786 NA 0.52 7.97 0.44 4.85e-14 Blood metabolite ratios; CESC cis rs539096 0.540 rs3011219 chr1:44306120 A/G cg12908607 chr1:44402522 ARTN -0.47 -6.96 -0.39 2.59e-11 Intelligence (multi-trait analysis); CESC cis rs2072732 0.821 rs12038530 chr1:2946726 T/A cg15211996 chr1:2936768 ACTRT2 0.33 5.76 0.33 2.36e-8 Plateletcrit; CESC cis rs7116495 0.609 rs6592447 chr11:71641093 A/T cg07596299 chr11:71824057 C11orf51 -0.8 -5.59 -0.32 5.72e-8 Severe influenza A (H1N1) infection; CESC cis rs2933343 0.729 rs789228 chr3:128601050 A/G cg25356066 chr3:128598488 ACAD9 0.66 9.22 0.49 9.52e-18 IgG glycosylation; CESC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg25036284 chr2:26402008 FAM59B -0.56 -6.51 -0.37 3.79e-10 Gut microbiome composition (summer); CESC cis rs7072216 0.763 rs7909822 chr10:100172035 A/C cg26618903 chr10:100175079 PYROXD2 -0.36 -5.68 -0.33 3.54e-8 Metabolite levels; CESC cis rs12956009 0.583 rs1115360 chr18:44894550 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.5 0.37 3.94e-10 Educational attainment (years of education); CESC cis rs709400 0.663 rs62007718 chr14:103940436 G/A cg12935359 chr14:103987150 CKB -0.57 -8.39 -0.46 2.88e-15 Body mass index; CESC cis rs7103648 1.000 rs7947450 chr11:47429904 G/A cg03711944 chr11:47377212 SPI1 -0.31 -5.05 -0.3 8.22e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs17818399 0.926 rs1378764 chr2:46839681 C/T cg02822958 chr2:46747628 ATP6V1E2 0.47 5.73 0.33 2.73e-8 Height; CESC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg00149659 chr3:10157352 C3orf10 0.7 8.26 0.45 6.82e-15 Alzheimer's disease; CESC cis rs3892630 0.529 rs35300319 chr19:33409948 G/A cg22980127 chr19:33182716 NUDT19 0.72 7.92 0.44 6.43e-14 Red blood cell traits; CESC cis rs9815354 1.000 rs2128834 chr3:41862645 A/G cg03022575 chr3:42003672 ULK4 0.5 5.63 0.33 4.67e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg05535760 chr7:792225 HEATR2 0.89 10.79 0.55 9.93e-23 Cerebrospinal P-tau181p levels; CESC cis rs698833 0.926 rs1067367 chr2:44654905 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.52 6.78 0.38 7.76e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9875589 0.957 rs60060718 chr3:13950333 G/A cg19554555 chr3:13937349 NA 0.52 6.52 0.37 3.48e-10 Ovarian reserve; CESC cis rs8180040 1.000 rs1024037 chr3:47318449 C/A cg27129171 chr3:47204927 SETD2 -0.67 -10.3 -0.53 3.84e-21 Colorectal cancer; CESC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.39 -0.5 2.94e-18 Alzheimer's disease; CESC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg22143856 chr6:28129313 ZNF389 0.42 5.27 0.31 2.83e-7 Parkinson's disease; CESC cis rs826838 0.967 rs11169169 chr12:39093153 A/C cg26384229 chr12:38710491 ALG10B 0.8 13.52 0.64 4.93e-32 Heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13165422 chr6:52926772 ICK 0.59 6.76 0.38 8.91e-11 Gut microbiome composition (summer); CESC cis rs7714584 1.000 rs12656538 chr5:150251380 A/G cg22134413 chr5:150180641 NA 0.61 5.92 0.34 9.83e-9 Crohn's disease; CESC cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg22307029 chr19:49891270 CCDC155 0.55 6.0 0.35 6.6e-9 Multiple sclerosis; CESC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg11965913 chr1:205819406 PM20D1 0.82 13.95 0.65 1.49e-33 Menarche (age at onset); CESC cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg13395646 chr4:1353034 KIAA1530 -0.41 -5.34 -0.31 1.98e-7 Longevity; CESC cis rs6089584 1.000 rs6089583 chr20:60563624 G/A cg13770153 chr20:60521292 NA -0.45 -5.91 -0.34 1.02e-8 Body mass index; CESC cis rs7044106 0.762 rs13291660 chr9:123392748 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.73 0.33 2.7e-8 Hip circumference adjusted for BMI; CESC cis rs12079745 0.793 rs76254504 chr1:169182779 T/A cg09363564 chr1:169337483 NME7;BLZF1 -1.0 -6.14 -0.35 3e-9 QT interval; CESC cis rs6456156 0.792 rs10946213 chr6:167516095 A/G cg23791538 chr6:167370224 RNASET2 0.41 5.38 0.31 1.61e-7 Primary biliary cholangitis; CESC cis rs3796352 0.892 rs3821872 chr3:53080555 C/G cg12962167 chr3:53033115 SFMBT1 -0.53 -5.09 -0.3 6.86e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg17724175 chr1:150552817 MCL1 -0.46 -7.65 -0.43 3.71e-13 Tonsillectomy; CESC cis rs561341 0.654 rs6505265 chr17:30172580 C/T cg00745463 chr17:30367425 LRRC37B 0.58 5.36 0.31 1.79e-7 Hip circumference adjusted for BMI; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22328890 chr16:68298258 SLC7A6 -0.44 -6.47 -0.37 4.67e-10 Gambling; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03789152 chr12:72233372 TBC1D15 -0.5 -6.36 -0.36 8.91e-10 Ulcerative colitis; CESC cis rs12900413 0.687 rs12913572 chr15:90319313 T/C cg24249390 chr15:90295951 MESP1 -0.42 -5.81 -0.34 1.78e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs2408955 0.522 rs4760612 chr12:48421856 C/T cg24011408 chr12:48396354 COL2A1 -0.52 -8.06 -0.44 2.55e-14 Glycated hemoglobin levels; CESC cis rs921968 0.643 rs4674321 chr2:219511368 G/A cg02176678 chr2:219576539 TTLL4 0.41 7.03 0.4 1.76e-11 Mean corpuscular hemoglobin concentration; CESC cis rs16867321 0.627 rs1025125 chr2:181580502 A/G cg23363182 chr2:181467187 NA 0.44 6.49 0.37 4.12e-10 Obesity; CESC cis rs10861342 0.786 rs11112393 chr12:105548053 C/T cg23923672 chr12:105501055 KIAA1033 0.66 5.5 0.32 8.92e-8 IgG glycosylation; CESC cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg26597838 chr10:835615 NA 1.17 11.57 0.58 2.57e-25 Eosinophil percentage of granulocytes; CESC cis rs12200560 0.505 rs211162 chr6:97067344 G/A cg06623918 chr6:96969491 KIAA0776 0.48 6.06 0.35 4.55e-9 Coronary heart disease; CESC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg18350739 chr11:68623251 NA 0.47 7.29 0.41 3.6e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7296418 0.961 rs949143 chr12:123595163 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.16 -0.3 4.74e-7 Platelet count; CESC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg24531977 chr5:56204891 C5orf35 -0.68 -8.63 -0.47 5.97e-16 Type 2 diabetes; CESC cis rs9325144 0.600 rs10785621 chr12:38744912 C/T cg26384229 chr12:38710491 ALG10B 0.56 8.07 0.44 2.52e-14 Morning vs. evening chronotype; CESC cis rs13392177 0.684 rs62185965 chr2:219073779 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.52 -6.44 -0.37 5.71e-10 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg11764359 chr7:65958608 NA 0.97 15.32 0.69 2.28e-38 Aortic root size; CESC cis rs7246657 0.943 rs34603719 chr19:37794528 T/G cg23950597 chr19:37808831 NA -0.63 -6.43 -0.37 5.83e-10 Coronary artery calcification; CESC cis rs13242816 1.000 rs13235720 chr7:116113663 T/C cg04696780 chr7:116139425 CAV2 -0.58 -5.2 -0.3 4.08e-7 P wave duration; CESC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg05564831 chr3:52568323 NT5DC2 0.44 6.64 0.38 1.77e-10 Bipolar disorder; CESC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.94 0.52 5.31e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04671591 chr1:147400503 GPR89B -0.61 -7.16 -0.4 7.82e-12 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg18337363 chr3:52569053 NT5DC2 0.29 5.27 0.31 2.85e-7 Bipolar disorder; CESC cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg11166453 chr1:247681781 NA 0.44 5.77 0.33 2.24e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs12995491 0.933 rs34029976 chr2:88537797 T/C cg04511125 chr2:88470314 THNSL2 -0.51 -7.44 -0.42 1.38e-12 Response to metformin (IC50); CESC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -6.85 -0.39 5.17e-11 Personality dimensions; CESC cis rs12995491 0.933 rs13023008 chr2:88530933 G/A cg07952391 chr2:88470173 THNSL2 -0.55 -8.33 -0.46 4.44e-15 Response to metformin (IC50); CESC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg06420487 chr17:61919686 SMARCD2 0.44 5.3 0.31 2.43e-7 Height; CESC cis rs5758659 0.653 rs133383 chr22:42473603 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.34 -5.73 -0.33 2.71e-8 Cognitive function; CESC cis rs3782089 0.546 rs76146604 chr11:65277512 G/T cg00206168 chr11:65308501 LTBP3 0.97 6.49 0.37 4.11e-10 Height; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg16490896 chr11:72853324 FCHSD2 0.43 6.04 0.35 5.24e-9 Thyroid stimulating hormone; CESC cis rs12478296 1.000 rs113129906 chr2:243004253 C/T cg06360820 chr2:242988706 NA -0.96 -10.24 -0.53 5.76e-21 Obesity-related traits; CESC cis rs12220238 1.000 rs111704178 chr10:75957251 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.45 0.32 1.13e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs644148 0.836 rs2686774 chr19:44999827 T/C cg15540054 chr19:45004280 ZNF180 -0.71 -8.42 -0.46 2.38e-15 Personality dimensions; CESC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg00684032 chr4:1343700 KIAA1530 0.36 5.56 0.32 6.59e-8 Longevity; CESC trans rs11264799 0.765 rs12125713 chr1:157636657 A/G cg22691776 chr3:15032403 NR2C2 0.33 6.15 0.35 2.92e-9 IgA nephropathy; CESC cis rs4727027 0.870 rs62507485 chr7:148764182 C/T cg23583168 chr7:148888333 NA -0.78 -11.73 -0.58 7.4e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3008870 1.000 rs1925408 chr1:67365034 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.02 14.11 0.65 4.32e-34 Lymphocyte percentage of white cells; CESC cis rs657075 0.697 rs3792880 chr5:131644965 A/C cg00255919 chr5:131827918 IRF1 -0.57 -5.09 -0.3 6.68e-7 Rheumatoid arthritis; CESC cis rs8103278 0.507 rs62111759 chr19:46296230 A/T cg12641515 chr19:46296257 DMWD 0.76 9.9 0.52 7.12e-20 Coronary artery disease; CESC cis rs2191566 0.664 rs7250774 chr19:44551867 A/T cg20607764 chr19:44506953 ZNF230 -0.44 -5.64 -0.33 4.34e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg06074448 chr4:187884817 NA -0.49 -7.54 -0.42 7.67e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7727544 0.735 rs274558 chr5:131721174 A/G cg07395648 chr5:131743802 NA 0.47 6.35 0.36 9.28e-10 Blood metabolite levels; CESC cis rs6089584 0.528 rs4925335 chr20:60627034 G/A cg24733560 chr20:60626293 TAF4 0.48 7.12 0.4 1e-11 Body mass index; CESC cis rs2115536 0.692 rs6495450 chr15:80162499 C/A cg00225070 chr15:80189496 MTHFS 0.41 5.42 0.32 1.32e-7 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs4835473 0.868 rs4629390 chr4:144656455 A/G cg25736465 chr4:144833511 NA -0.32 -5.07 -0.3 7.58e-7 Immature fraction of reticulocytes; CESC cis rs67478160 0.643 rs11628332 chr14:104241141 C/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.04 -0.4 1.65e-11 Schizophrenia; CESC cis rs7592578 0.882 rs16832765 chr2:191468762 T/C cg10560079 chr2:191398806 TMEM194B -0.64 -5.47 -0.32 1.07e-7 Diastolic blood pressure; CESC cis rs2050392 0.762 rs306587 chr10:30722908 G/C cg18806716 chr10:30721971 MAP3K8 -0.41 -5.88 -0.34 1.2e-8 Inflammatory bowel disease; CESC cis rs62064224 0.589 rs4132610 chr17:30801441 C/T cg18200150 chr17:30822561 MYO1D 0.39 5.07 0.3 7.34e-7 Schizophrenia; CESC cis rs9611565 0.592 rs5996037 chr22:41965292 A/G cg03806693 chr22:41940476 POLR3H -0.97 -11.84 -0.59 2.96e-26 Vitiligo; CESC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.78 0.59 4.93e-26 Alzheimer's disease; CESC trans rs9858542 0.953 rs6446264 chr3:49417243 C/A cg21659725 chr3:3221576 CRBN -0.55 -6.53 -0.37 3.34e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.66 9.36 0.5 3.64e-18 Menopause (age at onset); CESC cis rs1832871 0.672 rs6899322 chr6:158753669 G/T cg07165851 chr6:158734300 TULP4 0.61 6.43 0.37 5.94e-10 Height; CESC cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg14784868 chr12:69753453 YEATS4 0.6 8.41 0.46 2.62e-15 Blood protein levels; CESC cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg03467027 chr4:99064603 C4orf37 0.48 6.04 0.35 5.29e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.14 0.4 9.05e-12 Tonsillectomy; CESC cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.26 0.31 3.04e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05899741 chr4:43901084 NA -0.46 -6.09 -0.35 3.99e-9 Gut microbiome composition (summer); CESC cis rs208520 0.690 rs851467 chr6:66802721 A/G cg07460842 chr6:66804631 NA -1.0 -13.43 -0.64 1.05e-31 Exhaled nitric oxide output; CESC cis rs7927771 0.524 rs11039345 chr11:47720228 A/G cg18512352 chr11:47633146 NA 0.35 5.42 0.32 1.34e-7 Subjective well-being; CESC cis rs2444217 0.872 rs2531977 chr16:4043701 C/G cg09300795 chr16:4042428 ADCY9 0.6 9.3 0.5 5.28e-18 Body mass index; CESC cis rs9487051 0.676 rs9400268 chr6:109600550 C/T cg01475377 chr6:109611718 NA -0.44 -7.07 -0.4 1.34e-11 Reticulocyte fraction of red cells; CESC cis rs2228479 0.850 rs11648689 chr16:89806732 G/A cg06558623 chr16:89946397 TCF25 1.16 9.11 0.49 2.01e-17 Skin colour saturation; CESC cis rs72781680 0.948 rs72790326 chr2:24126153 C/T cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg04369109 chr6:150039330 LATS1 -0.43 -6.11 -0.35 3.56e-9 Lung cancer; CESC cis rs10129255 0.500 rs2027903 chr14:107215283 A/C cg07958169 chr14:107095056 NA -0.6 -9.64 -0.51 4.8e-19 Kawasaki disease; CESC cis rs2645694 0.626 rs2703120 chr4:77822470 G/A cg10057126 chr4:77819792 ANKRD56 0.57 8.46 0.46 1.78e-15 Emphysema distribution in smoking; CESC cis rs2404602 0.716 rs12902174 chr15:76863540 T/C cg26408565 chr15:76604113 ETFA -0.4 -5.72 -0.33 2.92e-8 Blood metabolite levels; CESC cis rs7011049 0.673 rs17256515 chr8:53827232 C/T cg26025543 chr8:53854495 NA 0.4 5.07 0.3 7.4e-7 Systolic blood pressure; CESC cis rs67311347 1.000 rs17078511 chr3:40396254 A/G cg24209194 chr3:40518798 ZNF619 0.42 5.28 0.31 2.76e-7 Renal cell carcinoma; CESC cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg25554036 chr4:6271136 WFS1 0.55 9.07 0.49 2.77e-17 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7146395 1 rs7146395 chr14:75228647 A/C cg11812906 chr14:75593930 NEK9 0.45 5.49 0.32 9.6e-8 Platelet count; CESC cis rs7666738 0.830 rs10031751 chr4:98939134 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg07507251 chr3:52567010 NT5DC2 0.4 7.02 0.4 1.89e-11 Bipolar disorder; CESC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg10351095 chr21:47802916 PCNT 0.44 5.93 0.34 9.33e-9 Testicular germ cell tumor; CESC cis rs6665290 0.935 rs1929864 chr1:227195500 T/G cg10327440 chr1:227177885 CDC42BPA -1.22 -32.73 -0.9 4.4e-95 Myeloid white cell count; CESC cis rs9457247 0.967 rs425039 chr6:167410527 C/T cg25258033 chr6:167368657 RNASET2 0.4 6.14 0.35 2.93e-9 Crohn's disease; CESC cis rs10484885 0.824 rs11967579 chr6:90540008 G/T cg13799429 chr6:90582589 CASP8AP2 -0.77 -7.03 -0.4 1.71e-11 QRS interval (sulfonylurea treatment interaction); CESC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg09658497 chr7:2847517 GNA12 -0.38 -5.64 -0.33 4.29e-8 Height; CESC cis rs933688 0.938 rs7708782 chr5:90718517 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.16 14.28 0.66 1.09e-34 Smoking behavior; CESC cis rs78456975 1.000 rs72776251 chr2:1525097 G/A cg01028140 chr2:1542097 TPO -0.62 -5.88 -0.34 1.2e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg03806693 chr22:41940476 POLR3H 1.2 14.94 0.68 5.18e-37 Vitiligo; CESC cis rs9457247 0.663 rs9457258 chr6:167444254 T/C cg25258033 chr6:167368657 RNASET2 0.37 5.4 0.31 1.51e-7 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14628942 chr2:128186071 PROC -0.55 -6.02 -0.35 5.71e-9 Gut microbiome composition (summer); CESC cis rs7605827 0.930 rs10207209 chr2:15512701 A/G cg19274914 chr2:15703543 NA 0.32 5.73 0.33 2.75e-8 Educational attainment (years of education); CESC cis rs6866344 0.697 rs11739893 chr5:178127837 G/A cg03877680 chr5:178157825 ZNF354A 0.76 8.63 0.47 5.64e-16 Neutrophil percentage of white cells; CESC cis rs6987853 0.686 rs7818789 chr8:42354257 A/G cg09913449 chr8:42400586 C8orf40 0.36 5.89 0.34 1.16e-8 Mean corpuscular hemoglobin concentration; CESC trans rs11098499 0.738 rs28408407 chr4:120376030 C/G cg25214090 chr10:38739885 LOC399744 0.7 9.96 0.52 4.71e-20 Corneal astigmatism; CESC cis rs11676348 0.714 rs4674254 chr2:218986077 T/C cg00012203 chr2:219082015 ARPC2 -0.56 -7.31 -0.41 3.18e-12 Ulcerative colitis; CESC cis rs3771570 1.000 rs62193202 chr2:242303717 G/A cg21155796 chr2:242212141 HDLBP 0.6 5.27 0.31 2.89e-7 Prostate cancer; CESC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg01341218 chr17:43662625 NA 0.92 10.64 0.55 3.07e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1018836 0.663 rs2205151 chr8:91483468 A/C cg16814680 chr8:91681699 NA -0.62 -8.27 -0.45 6.46e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs7216064 1.000 rs59950564 chr17:65860859 A/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.81 -0.48 1.63e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9811920 0.638 rs796978 chr3:99564321 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 5.5 0.32 9.11e-8 Axial length; CESC cis rs7147624 0.608 rs4902413 chr14:66187091 T/C cg03016385 chr14:66212404 NA -0.49 -5.15 -0.3 5.2e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs1215050 0.791 rs260893 chr4:98744785 A/C cg05340658 chr4:99064831 C4orf37 0.51 6.65 0.38 1.63e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.14 0.4 9.11e-12 Bipolar disorder; CESC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg19592336 chr6:28129416 ZNF389 0.61 8.14 0.45 1.54e-14 Depression; CESC cis rs6540559 0.546 rs634601 chr1:210421594 C/T cg25204440 chr1:209979598 IRF6 0.48 5.35 0.31 1.94e-7 Cleft lip with or without cleft palate; CESC cis rs2276314 0.857 rs72883058 chr18:33612917 G/A cg05985134 chr18:33552581 C18orf21 0.62 7.36 0.41 2.29e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs66573146 0.634 rs56097119 chr4:7018692 C/G cg00086871 chr4:6988644 TBC1D14 0.88 5.58 0.32 5.84e-8 Granulocyte percentage of myeloid white cells; CESC trans rs2823962 0.759 rs9984105 chr21:18016495 C/T cg06419850 chr17:4688683 VMO1 -0.43 -6.17 -0.35 2.48e-9 Amyotrophic lateral sclerosis; CESC cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg03467027 chr4:99064603 C4orf37 0.48 6.04 0.35 5.29e-9 Colonoscopy-negative controls vs population controls; CESC trans rs8073060 0.586 rs4795086 chr17:34042190 G/A cg19694781 chr19:47549865 TMEM160 0.69 6.3 0.36 1.25e-9 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg19729930 chr2:74357872 NA 0.96 14.17 0.66 2.67e-34 Gestational age at birth (maternal effect); CESC cis rs6912958 0.684 rs4707382 chr6:88320641 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.25 -0.31 3.18e-7 Monocyte percentage of white cells; CESC cis rs897984 0.806 rs12928852 chr16:30943988 C/T cg00531865 chr16:30841666 NA 0.51 7.12 0.4 1.01e-11 Dementia with Lewy bodies; CESC trans rs2727020 0.729 rs1164666 chr11:49295867 C/T cg15704280 chr7:45808275 SEPT13 -0.87 -14.59 -0.67 8.81e-36 Coronary artery disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12468647 chr15:75975061 CSPG4 -0.49 -6.4 -0.37 6.91e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg16606324 chr3:10149918 C3orf24 0.44 5.3 0.31 2.38e-7 Alzheimer's disease; CESC cis rs10851478 0.558 rs17478785 chr15:49740304 A/C cg08060515 chr15:49448048 GALK2;COPS2 0.51 6.36 0.36 8.62e-10 Oral cavity cancer; CESC cis rs7089973 0.966 rs12775180 chr10:116639754 T/C cg23260525 chr10:116636907 FAM160B1 0.36 5.57 0.32 6.33e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs8062405 0.755 rs12447461 chr16:28582941 C/A cg07382826 chr16:28625726 SULT1A1 0.4 6.59 0.38 2.4e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs3858704 0.517 rs7297186 chr12:111778178 C/T cg10833066 chr12:111807467 FAM109A -0.33 -5.29 -0.31 2.6e-7 Idiopathic osteonecrosis of the femoral head; CESC cis rs965469 1.000 rs6037579 chr20:3347980 G/A cg25506879 chr20:3388711 C20orf194 -0.58 -6.12 -0.35 3.43e-9 IFN-related cytopenia; CESC cis rs2637266 0.935 rs2583052 chr10:78403288 C/G cg18941641 chr10:78392320 NA 0.44 8.58 0.47 7.88e-16 Pulmonary function; CESC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg23281280 chr6:28129359 ZNF389 0.47 6.2 0.36 2.2e-9 Parkinson's disease; CESC cis rs8040855 0.627 rs62019482 chr15:85615027 A/C cg08123816 chr15:85640762 PDE8A -0.39 -5.79 -0.34 1.94e-8 Bulimia nervosa; CESC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg02711726 chr17:80685570 FN3KRP -0.39 -5.14 -0.3 5.32e-7 Glycated hemoglobin levels; CESC cis rs1008375 0.900 rs4698622 chr4:17589557 C/T cg16339924 chr4:17578868 LAP3 0.82 10.37 0.54 2.27e-21 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2985684 1.000 rs3007031 chr14:50102269 G/C cg15316458 chr14:50087796 RPL36AL;MGAT2 0.45 5.15 0.3 4.99e-7 Carotid intima media thickness; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04489846 chr17:79980949 LRRC45;STRA13 -0.44 -6.22 -0.36 1.97e-9 Gambling; CESC cis rs9309473 0.948 rs10183818 chr2:73714556 A/G cg20560298 chr2:73613845 ALMS1 -0.55 -6.9 -0.39 3.86e-11 Metabolite levels; CESC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg27588902 chr6:42928151 GNMT -0.29 -5.67 -0.33 3.64e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs61542988 0.570 rs10950919 chr7:22833821 A/G cg13679077 chr7:22862647 TOMM7 0.62 7.04 0.4 1.61e-11 Fibrinogen levels; CESC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 13.15 0.63 1e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs921968 0.541 rs642520 chr2:219423605 A/G cg02176678 chr2:219576539 TTLL4 -0.49 -8.94 -0.48 6.89e-17 Mean corpuscular hemoglobin concentration; CESC cis rs1568889 0.838 rs11030220 chr11:28145769 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 13.51 0.64 5.16e-32 Bipolar disorder; CESC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg02428538 chr16:24856791 SLC5A11 0.66 6.92 0.39 3.37e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.7 0.43 2.77e-13 Prudent dietary pattern; CESC cis rs3824867 0.959 rs4237544 chr11:47454271 G/T cg20307385 chr11:47447363 PSMC3 -0.49 -6.08 -0.35 4.07e-9 Mean corpuscular hemoglobin; CESC cis rs2011503 0.941 rs113145184 chr19:19419984 T/C cg11584989 chr19:19387371 SF4 0.67 7.93 0.44 6e-14 Bipolar disorder; CESC cis rs7927771 0.832 rs10838699 chr11:47386073 T/C cg18512352 chr11:47633146 NA 0.52 7.49 0.42 1.06e-12 Subjective well-being; CESC cis rs10876993 0.928 rs774890 chr12:58068388 C/T cg18357645 chr12:58087776 OS9 0.61 10.25 0.53 5.6e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs8017423 0.522 rs12887028 chr14:90819605 A/G cg14092571 chr14:90743983 NA 0.44 6.62 0.38 1.93e-10 Mortality in heart failure; CESC cis rs67311347 0.955 rs6782746 chr3:40510592 A/G cg09455208 chr3:40491958 NA -0.49 -8.32 -0.46 4.59e-15 Renal cell carcinoma; CESC cis rs7208859 0.623 rs609063 chr17:28951513 A/G cg19761014 chr17:28927070 LRRC37B2 0.87 6.6 0.38 2.2e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs7943203 0.962 rs11212636 chr11:108311965 G/A cg24643211 chr18:11851603 GNAL;CHMP1B -0.48 -6.05 -0.35 4.95e-9 Red blood cell count;Mean corpuscular volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22123309 chr1:31191561 MATN1 -0.5 -6.14 -0.35 2.96e-9 Ulcerative colitis; CESC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.15e-9 Aortic root size; CESC cis rs4835473 0.897 rs11735341 chr4:144637183 G/C cg25736465 chr4:144833511 NA -0.45 -6.81 -0.39 6.71e-11 Immature fraction of reticulocytes; CESC cis rs6580649 1.000 rs6580647 chr12:48403229 G/T cg05342945 chr12:48394962 COL2A1 0.53 6.73 0.38 1.05e-10 Lung cancer; CESC cis rs1538970 0.962 rs4660849 chr1:45819872 A/G cg06784218 chr1:46089804 CCDC17 -0.31 -5.15 -0.3 5.19e-7 Platelet count; CESC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg05341575 chr12:125625032 AACS 0.32 5.09 0.3 6.68e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg00677455 chr12:58241039 CTDSP2 0.52 6.65 0.38 1.69e-10 Multiple sclerosis; CESC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 5.02e-9 Prudent dietary pattern; CESC cis rs7103648 0.966 rs896817 chr11:47394305 A/G cg03711944 chr11:47377212 SPI1 0.33 5.21 0.3 3.79e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs6598955 0.670 rs7522905 chr1:26609259 C/T cg00852783 chr1:26633632 UBXN11 0.42 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs35955747 0.934 rs926928 chr22:31821719 G/A cg25791279 chr22:32026902 PISD -0.44 -5.19 -0.3 4.18e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs7824557 0.564 rs12550129 chr8:11233917 C/T cg21775007 chr8:11205619 TDH -0.52 -7.67 -0.43 3.23e-13 Retinal vascular caliber; CESC cis rs7666738 0.830 rs1426670 chr4:98923572 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.57 0.32 6.21e-8 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs10068203 chr5:206618 C/T cg22857025 chr5:266934 NA -1.28 -14.21 -0.66 1.88e-34 Breast cancer; CESC trans rs35146811 0.625 rs2906645 chr7:99817859 A/G cg13215871 chr17:75784724 NA -0.34 -6.39 -0.37 7.46e-10 Coronary artery disease; CESC cis rs1707322 0.647 rs6686944 chr1:46156308 G/T cg03146154 chr1:46216737 IPP 0.82 11.47 0.58 5.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg27266027 chr21:40555129 PSMG1 0.44 5.23 0.31 3.47e-7 Cognitive function; CESC cis rs9549260 0.755 rs7333037 chr13:41215256 A/T cg21288729 chr13:41239152 FOXO1 0.65 8.62 0.47 6.27e-16 Red blood cell count; CESC cis rs2380220 0.808 rs2380224 chr6:95895553 C/T cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg18032046 chr6:28092343 ZSCAN16 0.56 5.65 0.33 4.14e-8 Depression; CESC cis rs10927875 0.965 rs3961710 chr1:16313172 C/T cg22431228 chr1:16359049 CLCNKA 0.37 5.73 0.33 2.68e-8 Dilated cardiomyopathy; CESC cis rs9487051 0.735 rs351754 chr6:109537553 A/G cg01475377 chr6:109611718 NA 0.4 5.98 0.35 7.01e-9 Reticulocyte fraction of red cells; CESC cis rs9486719 0.843 rs2472876 chr6:96845723 A/G cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.76 -0.33 2.34e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs3780486 0.505 rs7868663 chr9:33141229 A/G cg13443165 chr9:33130375 B4GALT1 0.46 7.07 0.4 1.37e-11 IgG glycosylation; CESC cis rs3738443 0.520 rs6699577 chr1:247387454 G/A cg07706540 chr1:247373924 NA -0.45 -5.51 -0.32 8.4e-8 Alcohol dependence; CESC cis rs1620921 0.505 rs13203571 chr6:161208765 A/G cg01280913 chr6:161186852 NA -0.38 -5.66 -0.33 3.96e-8 Lipoprotein (a) - cholesterol levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg21271961 chr1:95285780 SLC44A3 0.47 6.38 0.36 7.73e-10 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.49 0.46 1.49e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9430161 0.611 rs12081197 chr1:11034239 T/C cg02454025 chr1:11042201 C1orf127 0.99 16.1 0.7 3.84e-41 Ewing sarcoma; CESC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg26335602 chr6:28129616 ZNF389 0.53 6.75 0.38 9.35e-11 Depression; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg00605358 chr12:89747739 DUSP6 -0.54 -6.09 -0.35 3.96e-9 Subjective well-being; CESC cis rs8060686 0.641 rs7188085 chr16:68113873 A/G cg26727032 chr16:67993705 SLC12A4 -0.56 -6.61 -0.38 2.06e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs752092 1.000 rs752092 chr15:101781934 C/T cg19997662 chr15:101784653 CHSY1 0.56 7.72 0.43 2.37e-13 Corneal structure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26185531 chr11:75479825 DGAT2 0.56 6.38 0.36 7.72e-10 Gut microbiome composition (summer); CESC cis rs6867032 0.917 rs10474734 chr5:2004208 A/G cg26168224 chr5:2018326 NA 0.77 12.75 0.62 2.4e-29 Gut microbiome composition (winter); CESC cis rs2742234 0.590 rs2565201 chr10:43618484 T/C cg15436174 chr10:43711423 RASGEF1A -0.46 -5.41 -0.32 1.39e-7 Hirschsprung disease; CESC cis rs8002861 0.846 rs12869521 chr13:44478346 A/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.45 -5.86 -0.34 1.39e-8 Leprosy; CESC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg07677032 chr17:61819896 STRADA 0.47 6.13 0.35 3.23e-9 Prudent dietary pattern; CESC cis rs28595532 0.748 rs113336496 chr4:119336957 C/T cg21605333 chr4:119757512 SEC24D 0.93 5.92 0.34 1.02e-8 Cannabis dependence symptom count; CESC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.09e-8 Alzheimer's disease; CESC cis rs1707322 0.686 rs3014235 chr1:46091512 A/G cg03146154 chr1:46216737 IPP -0.79 -11.05 -0.56 1.36e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg02475777 chr4:1388615 CRIPAK -0.68 -8.61 -0.47 6.5e-16 Longevity; CESC cis rs79976124 0.800 rs12194767 chr6:66639599 A/G cg07460842 chr6:66804631 NA 0.71 8.51 0.46 1.3e-15 Type 2 diabetes; CESC cis rs2439831 0.850 rs8042868 chr15:43939642 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.74 6.52 0.37 3.5e-10 Lung cancer in ever smokers; CESC cis rs1775715 0.737 rs2808090 chr10:32143208 A/C cg18675610 chr10:32216311 ARHGAP12 0.35 5.44 0.32 1.18e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9308731 0.568 rs6754736 chr2:111948541 T/C cg04202892 chr2:111875749 ACOXL 0.39 5.33 0.31 2.12e-7 Chronic lymphocytic leukemia; CESC cis rs1552244 0.608 rs3732962 chr3:10048951 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 7.95 0.44 5.32e-14 Alzheimer's disease; CESC cis rs9911578 0.902 rs12948746 chr17:57071892 A/G cg12560992 chr17:57184187 TRIM37 1.0 17.01 0.72 2.3e-44 Intelligence (multi-trait analysis); CESC trans rs57221529 0.709 rs72706611 chr5:561146 C/A cg25482853 chr8:67687455 SGK3 1.12 11.92 0.59 1.58e-26 Lung disease severity in cystic fibrosis; CESC cis rs4523957 0.620 rs9906467 chr17:2069003 C/T cg16513277 chr17:2031491 SMG6 -0.79 -11.85 -0.59 2.89e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs238295 0.805 rs1983694 chr20:5574134 T/C cg24001556 chr20:5591874 RP5-1022P6.2 -0.46 -5.19 -0.3 4.27e-7 Occipital cortical area (total cortical area interaction); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg05357137 chr10:28527770 MPP7 0.4 6.23 0.36 1.78e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs798554 0.704 rs798503 chr7:2789704 G/A cg13628971 chr7:2884303 GNA12 0.41 5.45 0.32 1.17e-7 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08591886 chr16:81111003 C16orf46 -0.46 -6.09 -0.35 3.92e-9 Ulcerative colitis; CESC cis rs2985684 0.894 rs8005990 chr14:50022248 G/A cg02151108 chr14:50098012 C14orf104 -0.38 -5.18 -0.3 4.4e-7 Carotid intima media thickness; CESC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg24829409 chr8:58192753 C8orf71 -0.67 -7.97 -0.44 4.6e-14 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04005938 chr7:148334417 NA -0.53 -6.88 -0.39 4.25e-11 Gut microbiota (bacterial taxa); CESC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg16680214 chr1:154839983 KCNN3 -0.45 -6.87 -0.39 4.46e-11 Prostate cancer; CESC cis rs1153858 1.000 rs12440038 chr15:45706739 A/G cg21132104 chr15:45694354 SPATA5L1 0.86 11.69 0.58 9.6e-26 Homoarginine levels; CESC cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.37 0.36 8.45e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs561341 1.000 rs550264 chr17:30317540 G/T cg20587970 chr11:113659929 NA -1.42 -18.3 -0.75 6.25e-49 Hip circumference adjusted for BMI; CESC trans rs1555543 0.517 rs2391766 chr1:96909240 T/C cg01125333 chr16:2835331 PRSS33 -0.52 -6.15 -0.35 2.86e-9 Body mass index; CESC cis rs6460942 0.597 rs17448193 chr7:12525641 G/A cg20607287 chr7:12443886 VWDE -0.71 -7.67 -0.43 3.19e-13 Coronary artery disease; CESC cis rs897984 0.568 rs4889651 chr16:30895545 C/T cg02466173 chr16:30829666 NA -0.44 -6.39 -0.37 7.24e-10 Dementia with Lewy bodies; CESC cis rs8099014 0.861 rs4245270 chr18:56112854 A/G cg19312305 chr18:56117016 MIR122 -0.27 -5.26 -0.31 3e-7 Platelet count; CESC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg04944784 chr2:26401820 FAM59B -0.93 -10.75 -0.55 1.28e-22 Gut microbiome composition (summer); CESC cis rs67311347 0.911 rs9849224 chr3:40392562 T/C cg24209194 chr3:40518798 ZNF619 0.45 5.94 0.34 8.86e-9 Renal cell carcinoma; CESC cis rs10129255 0.957 rs10141052 chr14:107184767 G/A cg07958169 chr14:107095056 NA -0.42 -5.87 -0.34 1.28e-8 Kawasaki disease; CESC trans rs1814175 0.587 rs847628 chr11:49927064 A/T cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs4450798 0.649 rs7631252 chr3:13803506 C/T cg05589046 chr3:13742034 LOC285375 0.33 5.11 0.3 6.31e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs684232 0.602 rs401592 chr17:551316 T/C cg12384639 chr17:618140 VPS53 0.41 5.31 0.31 2.36e-7 Prostate cancer; CESC cis rs11792861 0.926 rs7856626 chr9:111775502 C/G cg05043794 chr9:111880884 C9orf5 -0.42 -6.89 -0.39 4.05e-11 Menarche (age at onset); CESC cis rs3768617 0.811 rs12563494 chr1:183039698 G/A ch.1.3577855R chr1:183094577 LAMC1 0.66 9.15 0.49 1.56e-17 Fuchs's corneal dystrophy; CESC cis rs6088590 1.000 rs2180276 chr20:33360785 T/A cg24642439 chr20:33292090 TP53INP2 0.84 11.86 0.59 2.69e-26 Coronary artery disease; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg06500355 chr6:111804104 REV3L 0.46 6.15 0.35 2.79e-9 Myopia (pathological); CESC cis rs3091242 0.933 rs28530483 chr1:25740847 A/C cg02931644 chr1:25747376 RHCE 0.39 6.42 0.37 6.29e-10 Erythrocyte sedimentation rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14214323 chr14:35873275 NFKBIA 0.54 6.16 0.35 2.66e-9 Gut microbiome composition (summer); CESC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg11764359 chr7:65958608 NA -0.8 -8.87 -0.48 1.14e-16 Aortic root size; CESC cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg16339924 chr4:17578868 LAP3 0.66 8.45 0.46 1.95e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6991838 0.584 rs4449837 chr8:66488152 C/T cg13398993 chr8:66546079 ARMC1 -0.46 -5.54 -0.32 7.22e-8 Intelligence (multi-trait analysis); CESC cis rs7512552 0.839 rs11577600 chr1:150407443 G/A cg15654264 chr1:150340011 RPRD2 0.4 5.29 0.31 2.63e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs714031 0.967 rs5757763 chr22:40065005 A/G cg21377881 chr22:40064566 CACNA1I -0.39 -6.41 -0.37 6.78e-10 Schizophrenia; CESC cis rs2243480 1.000 rs7804223 chr7:65664559 T/G cg12463550 chr7:65579703 CRCP -0.73 -5.71 -0.33 3.1e-8 Diabetic kidney disease; CESC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg08470875 chr2:26401718 FAM59B -0.67 -7.5 -0.42 9.76e-13 Gut microbiome composition (summer); CESC cis rs12477438 0.501 rs2516833 chr2:99777405 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.62 0.61 6.6e-29 Chronic sinus infection; CESC trans rs2727020 0.576 rs1917321 chr11:49377760 A/C cg15704280 chr7:45808275 SEPT13 -0.67 -8.84 -0.48 1.33e-16 Coronary artery disease; CESC cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg11764359 chr7:65958608 NA 0.95 14.36 0.66 5.81e-35 Aortic root size; CESC cis rs4481887 0.893 rs10888347 chr1:248448566 T/C cg00666640 chr1:248458726 OR2T12 0.38 6.42 0.37 6.37e-10 Common traits (Other); CESC cis rs1790761 0.554 rs12787511 chr11:67401635 G/C cg24690094 chr11:67383802 NA -0.35 -5.48 -0.32 9.74e-8 Mean corpuscular volume; CESC trans rs11088226 0.681 rs2833903 chr21:33940819 C/T cg09050820 chr6:167586206 TCP10L2 0.83 7.75 0.43 2.01e-13 Gastritis; CESC cis rs5753618 0.509 rs5997902 chr22:31583007 A/G cg13145458 chr22:31556086 RNF185 0.49 5.5 0.32 8.74e-8 Colorectal cancer; CESC cis rs9291683 0.530 rs11723970 chr4:9980462 T/C cg00071950 chr4:10020882 SLC2A9 0.79 14.49 0.66 1.98e-35 Bone mineral density; CESC cis rs1448094 0.621 rs10863090 chr12:86282211 C/T cg02569458 chr12:86230093 RASSF9 0.42 6.15 0.35 2.81e-9 Major depressive disorder; CESC cis rs7927592 0.913 rs7106339 chr11:68240241 C/T cg20283391 chr11:68216788 NA -0.64 -7.78 -0.43 1.65e-13 Total body bone mineral density; CESC cis rs10883723 0.737 rs11191312 chr10:104278601 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.49 5.38 0.31 1.62e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs9611565 0.659 rs169361 chr22:41877989 A/G cg06634786 chr22:41940651 POLR3H 0.71 7.19 0.4 6.68e-12 Vitiligo; CESC cis rs4822044 0.617 rs13054514 chr22:42130383 A/G cg06634786 chr22:41940651 POLR3H 0.49 5.5 0.32 8.83e-8 Cannabis dependence symptom count; CESC cis rs1707322 1.000 rs4454479 chr1:46423555 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6011002 1.000 rs56010802 chr20:62304114 G/C cg15212369 chr20:62274085 STMN3 -0.57 -5.16 -0.3 4.82e-7 Dental caries; CESC cis rs4950322 0.570 rs66580541 chr1:146780541 T/G cg16700924 chr1:146552102 NA -0.41 -5.1 -0.3 6.37e-7 Protein quantitative trait loci; CESC cis rs7980687 0.596 rs1727319 chr12:123701353 T/C cg00376283 chr12:123451042 ABCB9 0.67 9.21 0.49 1.03e-17 Height;Educational attainment;Head circumference (infant); CESC cis rs561341 0.843 rs879945 chr17:30242796 G/A cg13647721 chr17:30228624 UTP6 0.77 8.85 0.48 1.32e-16 Hip circumference adjusted for BMI; CESC cis rs9987353 0.566 rs34491841 chr8:9065510 C/A cg15556689 chr8:8085844 FLJ10661 -0.57 -6.53 -0.37 3.4e-10 Recombination measurement; CESC cis rs7560272 0.723 rs13386124 chr2:73771695 C/G cg20560298 chr2:73613845 ALMS1 -0.44 -6.25 -0.36 1.6e-9 Schizophrenia; CESC cis rs7116495 1.000 rs4945434 chr11:71759087 A/G cg10381502 chr11:71823885 C11orf51 0.72 5.78 0.33 2.04e-8 Severe influenza A (H1N1) infection; CESC cis rs15676 0.947 rs2293968 chr9:131587240 G/A cg00228799 chr9:131580591 ENDOG 0.44 5.61 0.33 5.1e-8 Blood metabolite levels; CESC cis rs3749237 0.595 rs1464567 chr3:49459252 C/G cg02487422 chr3:49467188 NICN1 -0.53 -7.61 -0.42 4.73e-13 Resting heart rate; CESC cis rs2066819 1.000 rs79436528 chr12:56686997 C/T cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg11663144 chr21:46675770 NA -0.64 -10.02 -0.52 2.95e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4908768 0.501 rs910581 chr1:8529524 T/C cg00120948 chr1:8484417 RERE -0.34 -5.22 -0.31 3.65e-7 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CESC cis rs9916302 0.904 rs8077104 chr17:37530510 A/G cg20243544 chr17:37824526 PNMT -0.49 -6.14 -0.35 3.08e-9 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20936892 chr17:57297306 GDPD1 -0.47 -6.12 -0.35 3.29e-9 Gut microbiome composition (summer); CESC trans rs2235573 0.625 rs139905 chr22:38409596 C/T cg19894588 chr14:64061835 NA -0.46 -6.05 -0.35 5e-9 Glioblastoma;Glioma; CESC cis rs9297145 0.761 rs62473005 chr7:98742510 G/C cg05967295 chr7:98741636 SMURF1 0.9 9.17 0.49 1.34e-17 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs13385 0.769 rs13175916 chr5:139611508 T/C cg26211634 chr5:139558579 C5orf32 0.49 5.41 0.32 1.41e-7 Atrial fibrillation; CESC cis rs12135062 0.538 rs2651929 chr1:3101353 C/T cg25382214 chr1:3105252 PRDM16 0.36 5.24 0.31 3.36e-7 Migraine; CESC cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.25 0.31 3.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs847577 0.722 rs6951277 chr7:97711783 A/G cg24562669 chr7:97807699 LMTK2 0.63 10.27 0.53 4.67e-21 Breast cancer; CESC cis rs2486288 0.656 rs2271438 chr15:45557468 A/G cg21132104 chr15:45694354 SPATA5L1 -0.55 -6.71 -0.38 1.16e-10 Glomerular filtration rate; CESC cis rs2243480 1.000 rs13310597 chr7:65598540 A/G cg12463550 chr7:65579703 CRCP 0.73 5.68 0.33 3.5e-8 Diabetic kidney disease; CESC cis rs1670533 1.000 rs13119276 chr4:1051574 T/C cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.77e-7 Recombination rate (females); CESC cis rs9309473 0.950 rs6735946 chr2:73790058 A/G cg20560298 chr2:73613845 ALMS1 -0.53 -6.96 -0.39 2.6e-11 Metabolite levels; CESC cis rs244293 0.965 rs244361 chr17:53191356 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.05 -0.3 8.18e-7 Menarche (age at onset); CESC cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg26597838 chr10:835615 NA 1.16 11.43 0.57 7.45e-25 Eosinophil percentage of granulocytes; CESC cis rs7917772 0.582 rs12784963 chr10:104336986 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.4 -5.4 -0.31 1.49e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2070488 0.804 rs13092473 chr3:38458958 A/G cg24069376 chr3:38537580 EXOG 0.35 6.01 0.35 6.11e-9 Electrocardiographic conduction measures; CESC cis rs10504073 0.626 rs6472220 chr8:50008477 C/A cg00325661 chr8:49890786 NA 0.5 7.58 0.42 5.91e-13 Blood metabolite ratios; CESC cis rs11098499 0.954 rs12506546 chr4:120301618 T/C cg09307838 chr4:120376055 NA 0.92 12.54 0.61 1.23e-28 Corneal astigmatism; CESC cis rs453301 0.598 rs10104303 chr8:8834528 A/T cg15556689 chr8:8085844 FLJ10661 0.44 5.68 0.33 3.6e-8 Joint mobility (Beighton score); CESC cis rs7116495 0.609 rs567026 chr11:71769952 C/T cg26138937 chr11:71823887 C11orf51 1.29 8.23 0.45 8.75e-15 Severe influenza A (H1N1) infection; CESC cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg09658497 chr7:2847517 GNA12 -0.43 -6.86 -0.39 4.74e-11 Height; CESC cis rs854765 0.547 rs7223696 chr17:17915791 G/T cg09796270 chr17:17721594 SREBF1 0.38 5.38 0.31 1.65e-7 Total body bone mineral density; CESC cis rs6500395 0.926 rs11076572 chr16:48623621 T/G cg04672837 chr16:48644449 N4BP1 0.47 5.82 0.34 1.72e-8 Response to tocilizumab in rheumatoid arthritis; CESC trans rs561341 0.609 rs739800 chr17:30190083 T/A cg20587970 chr11:113659929 NA 0.57 6.96 0.39 2.65e-11 Hip circumference adjusted for BMI; CESC cis rs4242434 0.819 rs6999893 chr8:22465427 T/C cg03733263 chr8:22462867 KIAA1967 0.88 15.23 0.68 4.59e-38 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs672059 1.000 rs672059 chr1:183162539 G/A ch.1.3577855R chr1:183094577 LAMC1 0.55 7.16 0.4 7.77e-12 Hypertriglyceridemia; CESC cis rs933688 0.509 rs2973472 chr5:90519496 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.43 -5.23 -0.31 3.46e-7 Smoking behavior; CESC cis rs7772486 0.790 rs4280983 chr6:146280790 G/C cg05347473 chr6:146136440 FBXO30 -0.56 -7.17 -0.4 7.61e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09430954 chr19:46236890 NA -0.56 -6.39 -0.37 7.64e-10 Gut microbiome composition (summer); CESC cis rs6429082 0.806 rs2382570 chr1:235570523 G/A cg26050004 chr1:235667680 B3GALNT2 -0.41 -5.32 -0.31 2.19e-7 Adiposity; CESC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg06634786 chr22:41940651 POLR3H 0.74 7.63 0.42 4.36e-13 Vitiligo; CESC cis rs7923452 0.507 rs103441 chr10:30778184 C/T cg18806716 chr10:30721971 MAP3K8 -0.54 -8.17 -0.45 1.24e-14 Itch intensity from mosquito bite; CESC cis rs17407555 0.779 rs57757169 chr4:10115703 G/A cg00071950 chr4:10020882 SLC2A9 -0.53 -5.53 -0.32 7.69e-8 Schizophrenia (age at onset); CESC cis rs1801251 0.963 rs7591176 chr2:233581803 C/A cg25237894 chr2:233734115 C2orf82 0.5 8.36 0.46 3.53e-15 Coronary artery disease; CESC cis rs7520050 0.778 rs3014238 chr1:46090214 A/G cg03146154 chr1:46216737 IPP -0.5 -6.67 -0.38 1.5e-10 Red blood cell count;Reticulocyte count; CESC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10028773 0.568 rs6838457 chr4:120267367 A/G cg09307838 chr4:120376055 NA 0.76 10.03 0.52 2.87e-20 Educational attainment; CESC cis rs798766 1.000 rs2166580 chr4:1743169 G/A cg10756475 chr4:1757242 NA 0.47 6.08 0.35 4.14e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs10838687 0.932 rs4752973 chr11:47269159 T/C cg25783544 chr11:47291846 MADD 0.6 7.47 0.42 1.2e-12 Proinsulin levels; CESC cis rs2130392 0.886 rs2077205 chr4:185637418 C/T cg21366198 chr4:185655624 MLF1IP -0.42 -6.12 -0.35 3.29e-9 Kawasaki disease; CESC cis rs1163251 0.902 rs487081 chr1:120217389 G/A cg19096424 chr1:120255104 PHGDH 0.43 5.22 0.31 3.62e-7 Blood metabolite levels; CESC cis rs826838 0.967 rs11183577 chr12:38781887 A/G cg26384229 chr12:38710491 ALG10B 0.83 14.6 0.67 8.06e-36 Heart rate; CESC cis rs9914988 0.943 rs9898892 chr17:27150750 T/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs36051895 0.623 rs10975023 chr9:5239549 A/G cg02405213 chr9:5042618 JAK2 0.56 6.55 0.37 2.98e-10 Pediatric autoimmune diseases; CESC cis rs1062746 0.738 rs2303764 chr16:87377455 C/G cg02258303 chr16:87377426 FBXO31 0.47 6.12 0.35 3.34e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CESC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg23758822 chr17:41437982 NA 1.03 14.6 0.67 7.88e-36 Menopause (age at onset); CESC cis rs9905704 0.914 rs2611777 chr17:56826958 A/G cg12560992 chr17:57184187 TRIM37 0.61 7.09 0.4 1.25e-11 Testicular germ cell tumor; CESC cis rs4604732 0.631 rs12038793 chr1:247624262 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.6 -7.66 -0.43 3.46e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9287719 0.967 rs10929686 chr2:10743705 A/C cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.32e-8 Prostate cancer; CESC cis rs763121 0.813 rs2179143 chr22:39037984 A/G cg06544989 chr22:39130855 UNC84B 0.47 8.58 0.47 8.2e-16 Menopause (age at onset); CESC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.48 -0.54 9.87e-22 Alzheimer's disease; CESC cis rs9649465 1.000 rs56396297 chr7:123350535 T/C cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.34e-7 Migraine; CESC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg08859206 chr1:53392774 SCP2 -0.58 -7.3 -0.41 3.34e-12 Monocyte count; CESC cis rs910316 1.000 rs876402 chr14:75601862 C/T cg08847533 chr14:75593920 NEK9 -1.02 -20.0 -0.78 7.09e-55 Height; CESC cis rs6964587 1.000 rs61244255 chr7:91751662 C/T cg01689657 chr7:91764605 CYP51A1 0.28 5.06 0.3 7.82e-7 Breast cancer; CESC cis rs2243480 1.000 rs1701758 chr7:65470201 T/A cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg04055107 chr11:65626734 MUS81;CFL1 0.43 5.46 0.32 1.07e-7 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs116095464 0.558 rs7725227 chr5:233517 G/A cg10591111 chr5:226296 SDHA -0.51 -6.32 -0.36 1.13e-9 Breast cancer; CESC cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg24308560 chr3:49941425 MST1R -0.63 -9.14 -0.49 1.64e-17 Intelligence (multi-trait analysis); CESC cis rs9911578 1.000 rs1971659 chr17:57004787 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -6.81 -0.39 6.39e-11 Intelligence (multi-trait analysis); CESC cis rs7223966 1.000 rs56383601 chr17:61929968 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 5.85 0.34 1.45e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs12410462 0.581 rs7543931 chr1:227550976 A/T cg04117972 chr1:227635322 NA 0.66 5.6 0.33 5.36e-8 Major depressive disorder; CESC cis rs7927592 1.000 rs7927592 chr11:68369960 G/A cg20283391 chr11:68216788 NA -0.5 -5.97 -0.34 7.5e-9 Total body bone mineral density; CESC cis rs644799 0.965 rs499076 chr11:95546341 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs1606974 0.649 rs9973354 chr2:51929410 G/C cg21066735 chr11:15671806 NA -0.72 -6.0 -0.35 6.57e-9 Educational attainment (years of education);Educational attainment; CESC cis rs17431357 0.737 rs117725109 chr12:120981551 C/T cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs10465746 0.905 rs11163875 chr1:84429605 T/G cg10977910 chr1:84465055 TTLL7 0.46 6.18 0.35 2.45e-9 Obesity-related traits; CESC cis rs2070488 0.861 rs1858740 chr3:38438372 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.93 16.23 0.71 1.38e-41 Electrocardiographic conduction measures; CESC cis rs6570726 0.967 rs9403707 chr6:145800010 A/G cg05347473 chr6:146136440 FBXO30 0.42 5.54 0.32 7.36e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs3858526 0.676 rs10838772 chr11:5895754 T/C cg05234568 chr11:5960015 NA -0.51 -6.08 -0.35 4.15e-9 DNA methylation (variation); CESC cis rs12946454 0.668 rs4792867 chr17:43249444 C/T cg10701640 chr17:43249399 NA 0.45 8.4 0.46 2.7e-15 Systolic blood pressure; CESC cis rs7216064 1.000 rs62084240 chr17:65859233 C/A cg07042672 chr17:66097459 LOC651250 -0.51 -5.22 -0.31 3.55e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.47 0.42 1.15e-12 Tonsillectomy; CESC cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg06627628 chr2:24431161 ITSN2 -0.67 -6.45 -0.37 5.4e-10 Lymphocyte counts; CESC cis rs2929278 0.561 rs3099045 chr15:43923955 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.52 6.63 0.38 1.82e-10 Schizophrenia; CESC cis rs4234798 0.500 rs7661077 chr4:7219889 C/T cg18431297 chr4:7219810 SORCS2 0.55 9.27 0.49 6.97e-18 Insulin-like growth factors; CESC trans rs677673 1.000 rs617775 chr20:10478606 T/C cg16021678 chr13:55475951 NA 0.52 6.47 0.37 4.66e-10 Body mass index (change over time) in chronic obstructive pulmonary disease; CESC cis rs34779708 0.966 rs34776628 chr10:35426324 G/A cg03585969 chr10:35415529 CREM 0.76 10.3 0.53 3.72e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs936229 0.668 rs67411922 chr15:75187612 A/G cg10253484 chr15:75165896 SCAMP2 -0.44 -5.03 -0.3 9.07e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.55 -0.32 6.87e-8 Aortic root size; CESC cis rs8141529 0.673 rs132548 chr22:29317559 C/G cg15103426 chr22:29168792 CCDC117 -0.62 -8.21 -0.45 9.64e-15 Lymphocyte counts; CESC cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg11752832 chr7:134001865 SLC35B4 0.54 7.01 0.4 1.96e-11 Mean platelet volume; CESC cis rs4237845 0.514 rs4760339 chr12:58268149 G/T cg02175503 chr12:58329896 NA 0.51 6.08 0.35 4.27e-9 Intelligence (multi-trait analysis); CESC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg21800906 chr11:32914818 QSER1 0.48 6.45 0.37 5.2400000000000005e-10 Systemic lupus erythematosus; CESC cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.75 8.51 0.46 1.26e-15 Alzheimer's disease; CESC cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg06766960 chr11:133703094 NA -0.39 -5.6 -0.33 5.25e-8 Childhood ear infection; CESC cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.73 10.79 0.55 9.56e-23 Hip circumference adjusted for BMI; CESC cis rs11792861 0.962 rs72607162 chr9:111793719 T/C cg14384093 chr9:111878565 C9orf5 -0.41 -5.09 -0.3 6.73e-7 Menarche (age at onset); CESC cis rs1185460 0.967 rs1168568 chr11:118949799 G/A cg23280166 chr11:118938394 VPS11 0.55 7.46 0.42 1.25e-12 Coronary artery disease; CESC cis rs6690583 0.623 rs61769366 chr1:85534062 G/A cg22153463 chr1:85462885 MCOLN2 0.71 6.54 0.37 3.23e-10 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03849754 chr1:220220103 EPRS -0.53 -6.13 -0.35 3.14e-9 Gut microbiome composition (summer); CESC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg03060546 chr3:49711283 APEH 0.62 8.58 0.47 8.13e-16 Parkinson's disease; CESC cis rs7666738 0.546 rs1813970 chr4:98887167 A/G cg17366294 chr4:99064904 C4orf37 -0.48 -6.05 -0.35 4.89e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2933343 0.649 rs789219 chr3:128592520 G/A cg25356066 chr3:128598488 ACAD9 0.61 8.67 0.47 4.37e-16 IgG glycosylation; CESC cis rs7590720 0.819 rs1344694 chr2:216893637 T/G cg12620499 chr2:216877984 MREG 0.94 14.24 0.66 1.49e-34 Alcohol dependence; CESC cis rs6540556 0.643 rs2236903 chr1:209883480 A/T cg05527609 chr1:210001259 C1orf107 -0.45 -5.32 -0.31 2.19e-7 Red blood cell count; CESC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg25072359 chr17:41440525 NA 0.48 6.46 0.37 4.9e-10 Menopause (age at onset); CESC cis rs12618769 0.652 rs11896729 chr2:99225645 T/C cg10123293 chr2:99228465 UNC50 0.41 5.38 0.31 1.68e-7 Bipolar disorder; CESC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.11e-8 Alzheimer's disease; CESC cis rs12410462 0.581 rs7543931 chr1:227550976 A/T cg10327440 chr1:227177885 CDC42BPA -0.66 -5.46 -0.32 1.11e-7 Major depressive disorder; CESC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg23161317 chr6:28129485 ZNF389 0.49 6.02 0.35 5.87e-9 Parkinson's disease; CESC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg06481639 chr22:41940642 POLR3H -0.59 -6.29 -0.36 1.32e-9 Vitiligo; CESC cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg13319975 chr6:146136371 FBXO30 -0.42 -5.03 -0.3 9.05e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7584330 0.518 rs7585969 chr2:238439073 G/A cg14458575 chr2:238380390 NA 0.6 5.91 0.34 1.07e-8 Prostate cancer; CESC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg06873352 chr17:61820015 STRADA 0.71 12.33 0.6 6.72e-28 Prudent dietary pattern; CESC cis rs4233802 1.000 rs4577299 chr2:151138798 A/C cg25300694 chr2:151184358 NA -0.81 -7.28 -0.41 3.71e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04083751 chr10:73533414 CDH23;C10orf54 0.55 6.32 0.36 1.13e-9 Gut microbiome composition (summer); CESC cis rs10751667 0.961 rs7482484 chr11:927020 C/T cg20946044 chr11:1010712 AP2A2 -0.43 -5.63 -0.33 4.57e-8 Alzheimer's disease (late onset); CESC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg27211696 chr2:191398769 TMEM194B 0.52 7.75 0.43 2e-13 Pulse pressure; CESC cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg04450456 chr4:17643702 FAM184B 0.38 5.42 0.32 1.35e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.15e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6121246 0.529 rs2889528 chr20:30210021 C/T cg13852791 chr20:30311386 BCL2L1 0.59 5.49 0.32 9.22e-8 Mean corpuscular hemoglobin; CESC trans rs13035304 0.773 rs6727916 chr2:130510147 A/G cg18827756 chr15:42130735 JMJD7-PLA2G4B;PLA2G4B 0.45 6.21 0.36 1.98e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs34779708 0.931 rs58159560 chr10:35351249 C/T cg03585969 chr10:35415529 CREM 0.77 10.01 0.52 3.32e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg23583168 chr7:148888333 NA -0.74 -10.71 -0.55 1.73e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.53 -0.37 3.38e-10 Life satisfaction; CESC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg13206674 chr6:150067644 NUP43 0.43 6.02 0.35 5.84e-9 Lung cancer; CESC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg07936489 chr17:37558343 FBXL20 0.81 11.8 0.59 4.01e-26 Glomerular filtration rate (creatinine); CESC cis rs2845885 0.793 rs3751120 chr11:63884453 C/T cg26318627 chr11:63887540 MACROD1 -0.43 -5.12 -0.3 5.89e-7 Body mass index; CESC cis rs3771570 1.000 rs62193207 chr2:242318501 G/C cg21155796 chr2:242212141 HDLBP 0.6 5.27 0.31 2.89e-7 Prostate cancer; CESC cis rs7927592 0.956 rs10896348 chr11:68357368 T/C cg16797656 chr11:68205561 LRP5 0.41 6.02 0.35 5.92e-9 Total body bone mineral density; CESC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg00166722 chr3:10149974 C3orf24 0.51 6.38 0.37 7.76e-10 Alzheimer's disease; CESC cis rs9658691 0.607 rs12411452 chr10:90780607 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.57 -5.19 -0.3 4.25e-7 Mosquito bite size; CESC cis rs11048434 0.736 rs1805732 chr12:9090892 A/G cg23795048 chr12:9217529 LOC144571 -0.38 -5.81 -0.34 1.77e-8 Sjögren's syndrome; CESC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC trans rs629535 0.748 rs689410 chr8:70037558 G/A cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs9611565 0.649 rs202657 chr22:41844786 G/T cg06634786 chr22:41940651 POLR3H 0.69 6.93 0.39 3.16e-11 Vitiligo; CESC cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.23 0.31 3.46e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.58 -6.88 -0.39 4.37e-11 Gut microbiome composition (summer); CESC cis rs694739 1.000 rs646153 chr11:64089588 C/T cg23796481 chr11:64053134 BAD;GPR137 0.73 9.32 0.5 4.75e-18 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs2304069 0.954 rs6861548 chr5:149384680 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.91 11.57 0.58 2.48e-25 HIV-1 control; CESC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg26314531 chr2:26401878 FAM59B -0.76 -8.49 -0.46 1.47e-15 Gut microbiome composition (summer); CESC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg18016565 chr1:150552671 MCL1 -0.36 -5.36 -0.31 1.83e-7 Blood protein levels; CESC cis rs11048434 0.761 rs2110190 chr12:9128289 A/C cg23795048 chr12:9217529 LOC144571 0.34 5.05 0.3 8.31e-7 Sjögren's syndrome; CESC cis rs7219021 0.705 rs12939844 chr17:47025559 T/A cg16584676 chr17:46985605 UBE2Z -0.62 -7.12 -0.4 1.04e-11 Schizophrenia or bipolar disorder; CESC cis rs7528419 0.895 rs583104 chr1:109821307 G/T cg00908766 chr1:109817496 CELSR2 0.34 5.05 0.3 8.35e-7 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06725760 chr10:1102461 WDR37 0.57 6.31 0.36 1.18e-9 Gut microbiome composition (summer); CESC cis rs34172651 0.545 rs7185291 chr16:24714679 C/T cg06028605 chr16:24865363 SLC5A11 -0.39 -6.2 -0.36 2.12e-9 Intelligence (multi-trait analysis); CESC cis rs2251381 0.778 rs722013 chr21:30549245 G/T cg24692254 chr21:30365293 RNF160 0.78 10.72 0.55 1.6400000000000001e-22 Selective IgA deficiency; CESC cis rs977987 0.806 rs11640674 chr16:75394944 A/G cg03315344 chr16:75512273 CHST6 0.39 5.64 0.33 4.3e-8 Dupuytren's disease; CESC cis rs854765 0.583 rs9908832 chr17:17871068 C/T cg09796270 chr17:17721594 SREBF1 0.41 5.65 0.33 4.08e-8 Total body bone mineral density; CESC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg13206674 chr6:150067644 NUP43 0.46 6.59 0.38 2.43e-10 Lung cancer; CESC cis rs8077889 0.917 rs9901676 chr17:41911818 T/C cg26893861 chr17:41843967 DUSP3 0.76 10.25 0.53 5.58e-21 Triglycerides; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10620530 chr9:139922595 C9orf139;ABCA2 0.45 6.14 0.35 3.06e-9 Gut microbiota (bacterial taxa); CESC cis rs7937682 0.883 rs529529 chr11:111461128 C/T cg22437258 chr11:111473054 SIK2 0.71 9.09 0.49 2.34e-17 Primary sclerosing cholangitis; CESC cis rs561341 0.941 rs8066156 chr17:30361629 A/G cg00745463 chr17:30367425 LRRC37B -0.6 -6.13 -0.35 3.18e-9 Hip circumference adjusted for BMI; CESC cis rs7932354 0.528 rs7946709 chr11:47100796 G/T cg25783544 chr11:47291846 MADD -0.41 -5.46 -0.32 1.08e-7 Bone mineral density (hip);Bone mineral density; CESC cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg19077165 chr18:44547161 KATNAL2 0.55 8.06 0.44 2.61e-14 Personality dimensions; CESC cis rs2845885 0.793 rs3751120 chr11:63884453 C/T cg05555928 chr11:63887634 MACROD1 -0.54 -6.18 -0.35 2.43e-9 Body mass index; CESC cis rs11958404 0.932 rs6895484 chr5:157429159 T/C cg05962755 chr5:157440814 NA 0.62 6.53 0.37 3.41e-10 IgG glycosylation; CESC cis rs9467711 0.606 rs1978 chr6:26377573 A/T cg12826209 chr6:26865740 GUSBL1 0.66 5.65 0.33 4.13e-8 Autism spectrum disorder or schizophrenia; CESC cis rs6976053 0.518 rs314357 chr7:100410069 A/G cg03098644 chr7:100410630 EPHB4 -0.46 -5.88 -0.34 1.2e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs826838 0.804 rs6580755 chr12:39159190 C/T cg13010199 chr12:38710504 ALG10B 0.58 8.12 0.45 1.73e-14 Heart rate; CESC cis rs1788820 0.957 rs1652340 chr18:21099831 A/C cg14672496 chr18:21087552 C18orf8 0.53 7.19 0.4 6.58e-12 Body mass index; CESC cis rs4132509 0.948 rs12048930 chr1:243940076 C/T cg21452805 chr1:244014465 NA 0.52 6.3 0.36 1.22e-9 RR interval (heart rate); CESC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg11890956 chr21:40555474 PSMG1 1.19 23.04 0.82 3.05e-65 Cognitive function; CESC cis rs8044868 0.586 rs6499564 chr16:72189655 G/A cg16558253 chr16:72132732 DHX38 -0.39 -5.94 -0.34 8.84e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7635838 0.892 rs4684775 chr3:11436413 A/G cg00170343 chr3:11313890 ATG7 0.41 5.51 0.32 8.61e-8 HDL cholesterol; CESC cis rs3809863 0.602 rs11650072 chr17:45393665 A/G cg25173405 chr17:45401733 C17orf57 -0.53 -6.89 -0.39 4.16e-11 Glaucoma (primary open-angle); CESC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg03709012 chr19:19516395 GATAD2A 1.01 15.26 0.68 3.79e-38 Tonsillectomy; CESC cis rs9894429 0.538 rs9747080 chr17:79606704 A/G cg13777783 chr17:79615861 NA -0.36 -5.81 -0.34 1.77e-8 Eye color traits; CESC cis rs763014 0.931 rs2071980 chr16:626346 A/C cg09263875 chr16:632152 PIGQ 0.67 10.97 0.56 2.57e-23 Height; CESC cis rs7208859 0.673 rs216409 chr17:28906269 C/T cg14008862 chr17:28927542 LRRC37B2 -0.64 -5.8 -0.34 1.91e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.43e-7 Life satisfaction; CESC cis rs12155623 0.592 rs12682003 chr8:49865454 G/T cg22283653 chr8:49824208 NA 0.37 5.4 0.32 1.45e-7 Sudden cardiac arrest; CESC trans rs10242455 0.702 rs74347626 chr7:99206021 G/T cg09045935 chr12:6379348 NA 0.9 6.63 0.38 1.85e-10 Blood metabolite levels; CESC cis rs11252926 0.583 rs4881333 chr10:519164 G/C cg16386425 chr10:429943 DIP2C -0.47 -5.95 -0.34 8.27e-9 Psychosis in Alzheimer's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22403471 chr8:68256159 ARFGEF1 0.48 6.36 0.36 8.96e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs8060686 0.698 rs8044558 chr16:68210165 T/C cg26727032 chr16:67993705 SLC12A4 -0.51 -6.18 -0.36 2.35e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25517151 chr20:30467953 TTLL9 -0.43 -5.2 -0.3 3.91e-7 Ulcerative colitis; CESC cis rs644799 1.000 rs617999 chr11:95589935 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 6.2 0.36 2.17e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg16743903 chr16:89593216 SPG7 -0.43 -5.53 -0.32 7.51e-8 Multiple myeloma (IgH translocation); CESC cis rs9325144 0.581 rs2730929 chr12:38942739 T/C cg26384229 chr12:38710491 ALG10B -0.67 -10.82 -0.55 7.9399999999999994e-23 Morning vs. evening chronotype; CESC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg04944784 chr2:26401820 FAM59B -0.66 -7.62 -0.42 4.62e-13 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27176796 chr16:84495427 ATP2C2 -0.53 -6.44 -0.37 5.58e-10 Gut microbiome composition (summer); CESC cis rs287982 1.000 rs1119633 chr2:9967532 G/A cg10881225 chr2:9984929 TAF1B 0.42 5.31 0.31 2.27e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7539542 0.556 rs2000331 chr1:202857578 G/T cg19681188 chr1:202830198 LOC148709 0.44 5.62 0.33 4.71e-8 Mean platelet volume; CESC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg04756594 chr16:24857601 SLC5A11 0.5 5.8 0.34 1.92e-8 Intelligence (multi-trait analysis); CESC cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23422060 chr21:43916508 RSPH1 -0.49 -6.71 -0.38 1.18e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.592 rs5996038 chr22:41965300 T/C cg03806693 chr22:41940476 POLR3H -0.97 -11.84 -0.59 2.96e-26 Vitiligo; CESC trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg03929089 chr4:120376271 NA 0.72 9.88 0.52 8.34e-20 Height; CESC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg22433210 chr17:43662623 NA 0.6 7.75 0.43 2.02e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs55788414 1.000 rs9921827 chr16:81181869 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -7.04 -0.4 1.62e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg00701064 chr4:6280414 WFS1 0.68 11.33 0.57 1.53e-24 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs13385 0.769 rs7715649 chr5:139605517 G/A cg26211634 chr5:139558579 C5orf32 0.47 5.16 0.3 4.78e-7 Atrial fibrillation; CESC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg21782813 chr7:2030301 MAD1L1 -0.48 -6.86 -0.39 4.73e-11 Bipolar disorder and schizophrenia; CESC cis rs7264396 0.513 rs2425092 chr20:34306815 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.65 -0.55 2.79e-22 Total cholesterol levels; CESC cis rs7264396 0.563 rs6060580 chr20:34310512 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.66 6.86 0.39 4.97e-11 Total cholesterol levels; CESC cis rs72781680 0.611 rs55788848 chr2:24268721 C/T cg08917208 chr2:24149416 ATAD2B 0.63 6.09 0.35 3.87e-9 Lymphocyte counts; CESC cis rs1729951 0.546 rs835632 chr3:136676525 A/T cg25687071 chr3:136751404 NA 0.38 5.1 0.3 6.56e-7 Neuroticism; CESC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg14829155 chr15:31115871 NA -0.76 -10.62 -0.55 3.5e-22 Huntington's disease progression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04800816 chr11:93210603 NA -0.59 -6.5 -0.37 3.95e-10 Gut microbiome composition (summer); CESC cis rs2997447 0.761 rs56299762 chr1:26441638 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.41 0.32 1.41e-7 QRS complex (12-leadsum); CESC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.8 0.77 3.59e-54 Height; CESC cis rs9902453 1.000 rs8065059 chr17:28417376 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.79 -0.43 1.51e-13 Coffee consumption (cups per day); CESC cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg05347473 chr6:146136440 FBXO30 0.58 7.37 0.41 2.23e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7131987 0.644 rs6487817 chr12:29548210 G/A cg09582351 chr12:29534625 ERGIC2 0.35 5.52 0.32 8.2e-8 QT interval; CESC cis rs4660306 0.672 rs532639 chr1:46024481 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.6 -0.42 5.15e-13 Homocysteine levels; CESC cis rs8070128 0.568 rs3935505 chr17:17882020 T/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 6.84 0.39 5.57e-11 Total body bone mineral density; CESC cis rs9462846 0.959 rs9471960 chr6:42884750 A/C cg02353165 chr6:42928485 GNMT 0.45 5.23 0.31 3.51e-7 Blood protein levels; CESC cis rs888194 0.677 rs10850139 chr12:109875934 A/C cg19025524 chr12:109796872 NA -0.41 -6.24 -0.36 1.75e-9 Neuroticism; CESC cis rs2425143 0.908 rs11697087 chr20:34427583 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 5.22 0.31 3.67e-7 Blood protein levels; CESC trans rs1814175 0.586 rs10769603 chr11:49688837 T/C cg15704280 chr7:45808275 SEPT13 -0.97 -15.42 -0.69 1.02e-38 Height; CESC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg11859384 chr17:80120422 CCDC57 -0.4 -5.33 -0.31 2.14e-7 Life satisfaction; CESC cis rs11785400 0.793 rs4736362 chr8:143741381 G/A cg24634471 chr8:143751801 JRK 0.44 5.61 0.33 5.15e-8 Schizophrenia; CESC cis rs7116495 0.609 rs1892920 chr11:71702431 A/G cg18441811 chr11:71824068 C11orf51 -0.78 -5.16 -0.3 4.95e-7 Severe influenza A (H1N1) infection; CESC cis rs9486719 1.000 rs9400016 chr6:96940883 G/T cg18709589 chr6:96969512 KIAA0776 -0.54 -5.95 -0.34 8.34e-9 Migraine;Coronary artery disease; CESC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg26338869 chr17:61819248 STRADA 0.67 8.78 0.47 2.04e-16 Prudent dietary pattern; CESC trans rs9325144 0.510 rs7952795 chr12:38720686 C/T cg23762105 chr12:34175262 ALG10 -0.48 -6.38 -0.36 7.96e-10 Morning vs. evening chronotype; CESC cis rs11650494 0.710 rs11653775 chr17:47472365 A/G cg08112188 chr17:47440006 ZNF652 0.84 6.33 0.36 1.02e-9 Prostate cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14958951 chr2:178128766 NFE2L2 -0.58 -7.16 -0.4 7.88e-12 Ulcerative colitis; CESC cis rs7520050 0.966 rs12139630 chr1:46350935 A/G cg03146154 chr1:46216737 IPP -0.48 -6.22 -0.36 1.94e-9 Red blood cell count;Reticulocyte count; CESC cis rs17384381 0.861 rs35240561 chr1:85775217 C/G cg16011679 chr1:85725395 C1orf52 0.88 8.98 0.48 5.04e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs6754311 0.834 rs12465802 chr2:136381348 A/G cg07169764 chr2:136633963 MCM6 -0.59 -6.5 -0.37 3.89e-10 Mosquito bite size; CESC cis rs2066819 0.892 rs75274818 chr12:56627619 A/G cg26714650 chr12:56694279 CS -1.54 -10.81 -0.55 8.19e-23 Psoriasis vulgaris; CESC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg22823121 chr1:150693482 HORMAD1 0.47 6.97 0.39 2.5e-11 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17748167 chr1:31769917 ZCCHC17;SNRNP40 0.62 7.68 0.43 3e-13 Gut microbiome composition (summer); CESC cis rs1538970 1.000 rs1538970 chr1:45847562 G/A cg05343316 chr1:45956843 TESK2 0.82 11.49 0.58 4.44e-25 Platelet count; CESC cis rs16895831 0.519 rs16895856 chr6:42564921 A/C cg10605015 chr6:42532144 UBR2 -0.52 -5.76 -0.33 2.32e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.34 -0.31 2.02e-7 Lung cancer; CESC trans rs11098499 0.955 rs13129661 chr4:120152909 C/G cg25214090 chr10:38739885 LOC399744 0.65 8.59 0.47 7.54e-16 Corneal astigmatism; CESC cis rs11247915 0.600 rs3795686 chr1:26582091 G/A cg00852783 chr1:26633632 UBXN11 0.41 5.06 0.3 7.91e-7 Obesity-related traits; CESC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2573652 0.722 rs12898366 chr15:100543067 C/T cg09918751 chr15:100517450 ADAMTS17 -0.31 -5.73 -0.33 2.65e-8 Height; CESC cis rs965469 0.779 rs6051771 chr20:3328271 A/G cg17110299 chr20:3385021 C20orf194 0.4 5.25 0.31 3.1e-7 IFN-related cytopenia; CESC cis rs4727963 0.755 rs1525471 chr7:122733962 C/T cg03640110 chr7:122635026 TAS2R16 0.41 6.39 0.37 7.58e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs2933343 0.761 rs789225 chr3:128600229 G/A cg25356066 chr3:128598488 ACAD9 0.63 8.94 0.48 6.95e-17 IgG glycosylation; CESC cis rs4500972 1 rs4500972 chr2:73767897 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.23 -0.36 1.8e-9 Glomerular filtration rate (creatinine); CESC trans rs7726839 0.540 rs4957083 chr5:659343 T/C cg25482853 chr8:67687455 SGK3 0.93 9.54 0.51 9.85e-19 Obesity-related traits; CESC cis rs7020830 0.898 rs308495 chr9:37277603 G/T cg14294708 chr9:37120828 ZCCHC7 1.12 20.6 0.78 5.91e-57 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09248284 chr2:27851818 CCDC121;GPN1 0.6 7.05 0.4 1.6e-11 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs74940664 chr14:56135065 A/G cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs929596 0.556 rs35984508 chr2:234587852 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -5.28 -0.31 2.75e-7 Total bilirubin levels in HIV-1 infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14697246 chr3:48487981 ATRIP 0.58 6.37 0.36 8.13e-10 Gut microbiome composition (summer); CESC cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg17971929 chr21:40555470 PSMG1 1.05 15.27 0.68 3.41e-38 Cognitive function; CESC cis rs6500602 0.674 rs7191664 chr16:4541924 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.4 5.78 0.33 2.05e-8 Schizophrenia; CESC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg18963800 chr10:38644991 HSD17B7P2 -0.44 -5.48 -0.32 9.9e-8 Breast cancer; CESC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg04772025 chr11:68637568 NA 0.55 6.49 0.37 4.17e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg21747405 chr11:67723411 NA -0.44 -6.69 -0.38 1.3100000000000001e-10 Blood pressure (smoking interaction); CESC cis rs2204008 0.582 rs11179135 chr12:38204689 A/C cg13010199 chr12:38710504 ALG10B 0.53 6.43 0.37 5.94e-10 Bladder cancer; CESC cis rs2274273 0.967 rs8009670 chr14:55583477 G/A cg04306507 chr14:55594613 LGALS3 0.31 6.29 0.36 1.32e-9 Protein biomarker; CESC cis rs9831754 0.526 rs11927217 chr3:78341723 A/G cg06138941 chr3:78371609 NA -0.45 -5.96 -0.34 8.03e-9 Calcium levels; CESC cis rs9640161 0.711 rs3800781 chr7:150027324 T/A cg21361702 chr7:150065534 REPIN1 0.47 5.03 0.3 8.98e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs6831352 0.725 rs2602846 chr4:100025151 T/A cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.21e-14 Alcohol dependence; CESC cis rs763121 0.853 rs2076028 chr22:39150450 G/A cg06544989 chr22:39130855 UNC84B 0.51 9.01 0.48 4.1e-17 Menopause (age at onset); CESC cis rs1538970 0.816 rs12029322 chr1:45970446 C/T cg06784218 chr1:46089804 CCDC17 0.37 5.9 0.34 1.11e-8 Platelet count; CESC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg17178900 chr1:205818956 PM20D1 0.8 13.19 0.63 7.15e-31 Menarche (age at onset); CESC cis rs6674176 0.569 rs11210935 chr1:44369444 G/A cg12908607 chr1:44402522 ARTN -0.43 -5.96 -0.34 7.83e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6893300 0.506 rs35320050 chr5:179131013 C/T cg14593053 chr5:179126677 CANX 0.59 8.53 0.46 1.16e-15 Resting heart rate; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11656663 chr1:202976539 TMEM183A;TMEM183B -0.51 -6.18 -0.35 2.38e-9 Ulcerative colitis; CESC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg24838063 chr12:130822603 PIWIL1 -0.48 -6.92 -0.39 3.41e-11 Menopause (age at onset); CESC cis rs5758659 0.714 rs5751216 chr22:42508937 G/T cg04733989 chr22:42467013 NAGA -0.45 -6.23 -0.36 1.83e-9 Cognitive function; CESC cis rs1594829 0.553 rs2046225 chr8:26151802 A/C cg11498726 chr8:26250323 BNIP3L 0.42 6.3 0.36 1.21e-9 Height; CESC cis rs17021463 0.676 rs62320932 chr4:95307037 C/T cg11021082 chr4:95130006 SMARCAD1 0.52 7.18 0.4 6.91e-12 Testicular germ cell tumor; CESC cis rs6963495 0.818 rs55983796 chr7:105170941 C/T cg13798780 chr7:105162888 PUS7 0.77 7.87 0.44 9.18e-14 Bipolar disorder (body mass index interaction); CESC cis rs2625529 0.652 rs2957724 chr15:72248474 A/C cg16672083 chr15:72433130 SENP8 0.41 6.25 0.36 1.61e-9 Red blood cell count; CESC cis rs7259376 0.936 rs2195964 chr19:22538338 C/T cg02657401 chr19:22469223 NA -0.25 -5.08 -0.3 7.02e-7 Menopause (age at onset); CESC cis rs4234798 1.000 rs4689088 chr4:7222253 G/A cg18431297 chr4:7219810 SORCS2 0.47 7.59 0.42 5.63e-13 Insulin-like growth factors; CESC cis rs611744 0.647 rs2597658 chr8:109256014 C/T cg21045802 chr8:109455806 TTC35 0.51 6.2 0.36 2.15e-9 Dupuytren's disease; CESC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg00310523 chr12:86230176 RASSF9 -0.35 -5.52 -0.32 8.27e-8 Major depressive disorder; CESC trans rs6084875 0.641 rs4815737 chr20:4722770 C/G cg10192164 chr16:30419175 ZNF771 -0.5 -6.16 -0.35 2.7e-9 Systemic lupus erythematosus; CESC cis rs6701037 0.512 rs4650716 chr1:175128711 C/A cg00321850 chr1:175162397 KIAA0040 0.46 6.61 0.38 2.15e-10 Alcohol dependence; CESC cis rs10504073 0.584 rs10957356 chr8:49980634 G/A cg00325661 chr8:49890786 NA 0.58 8.69 0.47 3.86e-16 Blood metabolite ratios; CESC cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.47 0.46 1.72e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2288073 0.965 rs36101491 chr2:24387532 C/T cg20701182 chr2:24300061 SF3B14 0.49 5.4 0.31 1.49e-7 Venous thromboembolism (SNP x SNP interaction); CESC cis rs1355223 0.867 rs7925421 chr11:34681677 G/A cg11058730 chr11:34937778 PDHX;APIP -0.49 -6.41 -0.37 6.59e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs17067123 1.000 rs17067123 chr4:180048362 C/T cg26610307 chr4:180072759 NA -0.56 -6.06 -0.35 4.63e-9 Response to hepatitis C treatment; CESC cis rs66573146 0.656 rs111560662 chr4:6952766 C/T cg00086871 chr4:6988644 TBC1D14 0.97 5.99 0.35 6.8e-9 Granulocyte percentage of myeloid white cells; CESC cis rs1065852 0.526 rs9607869 chr22:42418110 T/A cg22189786 chr22:42395067 WBP2NL 0.45 5.65 0.33 4.07e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.5 0.46 1.36e-15 Electroencephalogram traits; CESC trans rs1973993 0.745 rs986427 chr1:96932736 A/G cg10631902 chr5:14652156 NA -0.5 -6.65 -0.38 1.7e-10 Weight; CESC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg21782813 chr7:2030301 MAD1L1 0.5 7.18 0.4 6.92e-12 Bipolar disorder and schizophrenia; CESC cis rs7560272 0.538 rs12233115 chr2:73931891 G/A cg20560298 chr2:73613845 ALMS1 0.47 6.47 0.37 4.84e-10 Schizophrenia; CESC cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg24308560 chr3:49941425 MST1R 0.6 8.57 0.47 8.95e-16 Intelligence (multi-trait analysis); CESC cis rs4803468 0.967 rs3826713 chr19:41892269 C/T cg14132834 chr19:41945861 ATP5SL -0.56 -6.91 -0.39 3.57e-11 Height; CESC cis rs72781680 1.000 rs72781679 chr2:24237712 G/A cg08917208 chr2:24149416 ATAD2B 1.13 9.83 0.52 1.17e-19 Lymphocyte counts; CESC cis rs1215050 0.740 rs804051 chr4:98935935 A/T cg17366294 chr4:99064904 C4orf37 -0.38 -5.04 -0.3 8.58e-7 Waist-to-hip ratio adjusted for body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19572947 chr1:182808556 DHX9 0.48 6.07 0.35 4.36e-9 Gut microbiota (bacterial taxa); CESC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg20891558 chr2:74357851 NA 0.76 10.75 0.55 1.31e-22 Gestational age at birth (maternal effect); CESC cis rs73206853 0.686 rs56339227 chr12:111164963 T/C cg12870014 chr12:110450643 ANKRD13A 0.64 5.66 0.33 3.91e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs6840258 0.941 rs6854749 chr4:87968798 A/T cg08197287 chr4:87952173 AFF1 -0.37 -5.06 -0.3 7.8e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg18876405 chr7:65276391 NA 0.48 6.32 0.36 1.09e-9 Aortic root size; CESC cis rs919433 0.817 rs10931780 chr2:198175297 G/C cg03934865 chr2:198174659 NA -0.49 -7.67 -0.43 3.24e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7542091 0.704 rs7537294 chr1:210043777 A/G cg21951975 chr1:209979733 IRF6 0.47 8.25 0.45 7.51e-15 Monobrow; CESC cis rs7666738 0.609 rs35214820 chr4:98864692 G/A cg05340658 chr4:99064831 C4orf37 0.53 6.33 0.36 1.04e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9303401 0.614 rs34678056 chr17:57177549 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.92 11.49 0.58 4.47e-25 Cognitive test performance; CESC cis rs611744 0.810 rs672161 chr8:109164182 G/A cg21045802 chr8:109455806 TTC35 0.45 5.49 0.32 9.39e-8 Dupuytren's disease; CESC cis rs8031584 0.958 rs34909055 chr15:31284170 C/T cg08704250 chr15:31115839 NA -0.52 -6.59 -0.38 2.37e-10 Huntington's disease progression; CESC cis rs422421 1.000 rs442856 chr5:176517292 A/G cg00618323 chr5:176515533 FGFR4 0.4 5.19 0.3 4.18e-7 Height; CESC cis rs2204008 0.806 rs3922574 chr12:38329069 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.82 0.55 7.48e-23 Bladder cancer; CESC cis rs826838 0.874 rs10880943 chr12:38734317 C/T cg26384229 chr12:38710491 ALG10B 0.84 15.0 0.68 3e-37 Heart rate; CESC cis rs684232 0.602 rs445268 chr17:563338 G/A cg15660573 chr17:549704 VPS53 -0.81 -11.96 -0.59 1.18e-26 Prostate cancer; CESC cis rs11583043 0.708 rs874905 chr1:101539702 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 5.41 0.32 1.42e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs1050631 0.924 rs1785918 chr18:33693198 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.44 5.62 0.33 4.79e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs4820539 1.000 rs916585 chr22:23469438 G/A cg14186256 chr22:23484241 RTDR1 0.83 15.0 0.68 3.12e-37 Bone mineral density; CESC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12545109 0.800 rs1561224 chr8:57419922 T/C cg09654669 chr8:57350985 NA -0.45 -6.27 -0.36 1.47e-9 Obesity-related traits; CESC cis rs295140 0.605 rs159321 chr2:201184713 C/T cg23649088 chr2:200775458 C2orf69 -0.46 -6.28 -0.36 1.41e-9 QT interval; CESC cis rs55986470 0.703 rs11887099 chr2:239447550 T/C cg18131467 chr2:239335373 ASB1 -0.54 -6.09 -0.35 3.99e-9 Chronotype; CESC cis rs1559088 1.000 rs2161225 chr19:33551899 C/T cg17764715 chr19:33622953 WDR88 0.46 5.85 0.34 1.42e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9287719 0.967 rs12467642 chr2:10761484 G/A cg02196655 chr2:10830764 NOL10 -0.37 -5.56 -0.32 6.58e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18810133 chr1:6557779 PLEKHG5 0.56 6.18 0.35 2.35e-9 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs28480159 chr4:17685707 A/C cg02297831 chr4:17616191 MED28 0.42 5.44 0.32 1.2e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8050907 0.744 rs13330134 chr16:4526923 T/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs10832963 0.924 rs10832950 chr11:18635815 A/G cg20219074 chr11:18656078 SPTY2D1 0.8 11.77 0.59 5.17e-26 Breast cancer; CESC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg05617483 chr15:76483344 C15orf27 0.42 5.62 0.33 4.95e-8 Blood metabolite levels; CESC cis rs35740288 0.539 rs11629991 chr15:86336664 A/G cg20737812 chr15:86336631 KLHL25 -0.42 -5.28 -0.31 2.71e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC trans rs3780486 0.846 rs7864705 chr9:33140352 A/C cg04842962 chr6:43655489 MRPS18A 1.01 20.1 0.78 3.2e-55 IgG glycosylation; CESC cis rs7044106 0.615 rs10818470 chr9:123359204 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.32 5.12 0.3 5.97e-7 Hip circumference adjusted for BMI; CESC cis rs4074961 0.604 rs4411102 chr1:38063424 C/G cg13401533 chr1:37979913 MEAF6 0.54 7.12 0.4 1.04e-11 Axial length; CESC cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg06544989 chr22:39130855 UNC84B 0.52 9.06 0.49 2.96e-17 Menopause (age at onset); CESC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg23281280 chr6:28129359 ZNF389 0.47 6.51 0.37 3.76e-10 Parkinson's disease; CESC cis rs13242816 1.000 rs34234085 chr7:116114066 G/A cg04696780 chr7:116139425 CAV2 -0.58 -5.2 -0.3 4.08e-7 P wave duration; CESC cis rs55986470 0.646 rs112559043 chr2:239446187 A/G cg18131467 chr2:239335373 ASB1 -0.79 -5.94 -0.34 9.01e-9 Chronotype; CESC cis rs9488822 0.702 rs10872141 chr6:116323246 C/A cg05304507 chr6:116381966 FRK 0.26 6.56 0.37 2.82e-10 Cholesterol, total;LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10073349 chr19:1568082 MEX3D 0.62 7.39 0.41 1.95e-12 Gut microbiome composition (summer); CESC cis rs72781680 0.898 rs72782138 chr2:24048162 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg06634786 chr22:41940651 POLR3H -0.72 -7.51 -0.42 9.19e-13 Vitiligo; CESC cis rs9611565 0.592 rs4481089 chr22:41980892 T/C cg17376030 chr22:41985996 PMM1 0.49 5.49 0.32 9.33e-8 Vitiligo; CESC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.79e-7 Gut microbiome composition (summer); CESC cis rs2249694 0.922 rs4306261 chr10:135410989 A/G cg20169779 chr10:135381914 SYCE1 -0.4 -5.65 -0.33 4.05e-8 Obesity-related traits; CESC cis rs6460942 1.000 rs6948314 chr7:12418363 T/A cg06484146 chr7:12443880 VWDE -0.66 -7.86 -0.43 9.73e-14 Coronary artery disease; CESC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg18446336 chr7:2847575 GNA12 -0.37 -5.38 -0.31 1.65e-7 Height; CESC cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg09021430 chr5:549028 NA -0.43 -5.41 -0.32 1.43e-7 Lung disease severity in cystic fibrosis; CESC cis rs1691799 0.867 rs1168342 chr12:66758734 A/T cg16791601 chr12:66731901 HELB -0.79 -14.11 -0.65 4.25e-34 White blood cell count (basophil); CESC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.83 12.0 0.59 8.55e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9814567 1.000 rs11919350 chr3:134235970 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.15e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs10129255 0.500 rs4774008 chr14:107137290 A/T cg23076370 chr14:107095027 NA -0.67 -10.15 -0.53 1.14e-20 Kawasaki disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08621418 chr6:79944414 HMGN3 -0.47 -6.46 -0.37 4.89e-10 Fibrinogen levels; CESC cis rs17401966 1.000 rs12130220 chr1:10359944 T/G cg15208524 chr1:10270712 KIF1B 0.48 6.11 0.35 3.52e-9 Hepatocellular carcinoma; CESC cis rs8114671 0.562 rs34837802 chr20:33424908 C/G cg24642439 chr20:33292090 TP53INP2 0.45 5.44 0.32 1.2e-7 Height; CESC cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 5.42 0.32 1.35e-7 Bipolar disorder; CESC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg26398791 chr1:38455867 SF3A3 -0.43 -5.49 -0.32 9.36e-8 Coronary artery disease; CESC cis rs72634258 0.945 rs2050198 chr1:8111839 T/G cg00042356 chr1:8021962 PARK7 0.76 6.78 0.38 7.86e-11 Inflammatory bowel disease; CESC cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg05340658 chr4:99064831 C4orf37 0.81 12.42 0.61 3.22e-28 Colonoscopy-negative controls vs population controls; CESC trans rs116095464 0.558 rs10056628 chr5:279512 G/A cg00938859 chr5:1591904 SDHAP3 0.72 6.62 0.38 2.03e-10 Breast cancer; CESC cis rs1950626 0.743 rs12887333 chr14:101462612 C/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.84 10.54 0.54 6.26e-22 Pelvic organ prolapse (moderate/severe); CESC cis rs6088580 0.634 rs6058070 chr20:33103521 G/C cg08999081 chr20:33150536 PIGU 0.65 11.45 0.58 6.19e-25 Glomerular filtration rate (creatinine); CESC cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs694739 0.628 rs538147 chr11:64129722 G/A cg02228329 chr11:64053129 BAD;GPR137 0.61 7.61 0.42 4.85e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs10870270 0.956 rs4131689 chr10:133744328 A/C cg08754478 chr10:133766260 PPP2R2D 0.59 7.77 0.43 1.78e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs870825 0.616 rs4263438 chr4:185624238 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg23758822 chr17:41437982 NA 0.99 17.26 0.73 2.91e-45 Menopause (age at onset); CESC cis rs4595586 0.505 rs12827467 chr12:39374014 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs2191566 0.576 rs381091 chr19:44495315 G/A cg20607764 chr19:44506953 ZNF230 0.45 5.69 0.33 3.38e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg25019033 chr10:957182 NA -0.55 -6.1 -0.35 3.79e-9 Eosinophil percentage of granulocytes; CESC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg24060327 chr5:131705240 SLC22A5 -0.41 -5.21 -0.3 3.79e-7 Breast cancer; CESC cis rs12711979 0.509 rs10187740 chr2:3823965 A/G cg17052675 chr2:3827356 NA 0.64 10.71 0.55 1.75e-22 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs11190604 1.000 rs4919470 chr10:102298920 C/T cg07080220 chr10:102295463 HIF1AN 0.64 5.81 0.34 1.78e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg17724175 chr1:150552817 MCL1 0.41 6.23 0.36 1.83e-9 Melanoma; CESC cis rs778371 1.000 rs709937 chr2:233744021 A/G cg08000102 chr2:233561755 GIGYF2 0.82 13.01 0.62 3.07e-30 Schizophrenia; CESC cis rs6963495 0.818 rs117028299 chr7:105162310 T/C cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs1552244 0.554 rs34883592 chr3:10046165 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 7.99 0.44 4.24e-14 Alzheimer's disease; CESC cis rs3768617 0.782 rs12143211 chr1:182990172 C/G ch.1.3577855R chr1:183094577 LAMC1 0.66 9.04 0.49 3.3e-17 Fuchs's corneal dystrophy; CESC cis rs16854884 0.837 rs13083224 chr3:143801696 C/T cg06585982 chr3:143692056 C3orf58 0.43 5.34 0.31 2.03e-7 Economic and political preferences (feminism/equality); CESC cis rs9584850 0.794 rs17574433 chr13:99138057 A/G cg20750642 chr13:99100586 FARP1 0.37 5.55 0.32 6.98e-8 Neuroticism; CESC cis rs9611565 0.921 rs5758297 chr22:41720697 A/G cg03806693 chr22:41940476 POLR3H -0.67 -8.06 -0.44 2.57e-14 Vitiligo; CESC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg01341218 chr17:43662625 NA 0.51 6.64 0.38 1.8e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2933343 0.700 rs1683777 chr3:128624880 T/G cg11901034 chr3:128598214 ACAD9 -0.39 -5.71 -0.33 3.1e-8 IgG glycosylation; CESC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.54 -0.32 7.11e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg18252515 chr7:66147081 NA -0.47 -6.08 -0.35 4.25e-9 Aortic root size; CESC cis rs56046484 0.826 rs35816571 chr15:85554122 C/G cg08123816 chr15:85640762 PDE8A -0.5 -5.89 -0.34 1.14e-8 Testicular germ cell tumor; CESC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg22920501 chr2:26401640 FAM59B 0.93 10.89 0.56 4.54e-23 Gut microbiome composition (summer); CESC cis rs11864453 0.826 rs6499559 chr16:72132064 G/C cg01557791 chr16:72042693 DHODH -0.51 -6.59 -0.38 2.43e-10 Fibrinogen levels; CESC cis rs9916302 0.861 rs11078896 chr17:37415544 C/T cg00129232 chr17:37814104 STARD3 -0.56 -7.24 -0.41 4.76e-12 Glomerular filtration rate (creatinine); CESC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg25036284 chr2:26402008 FAM59B -0.84 -9.59 -0.51 7.11e-19 Gut microbiome composition (summer); CESC cis rs9300255 0.602 rs2510885 chr12:123614813 G/C cg05973401 chr12:123451056 ABCB9 0.51 5.91 0.34 1.08e-8 Neutrophil percentage of white cells; CESC cis rs9486719 1.000 rs12193732 chr6:96942609 G/A cg18709589 chr6:96969512 KIAA0776 -0.55 -6.02 -0.35 5.81e-9 Migraine;Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20690483 chr2:96874741 STARD7 0.55 6.29 0.36 1.27e-9 Gut microbiome composition (summer); CESC cis rs11098499 0.542 rs10440343 chr4:120309787 G/C cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC trans rs629535 0.590 rs62513426 chr8:70136843 T/G cg21567404 chr3:27674614 NA -0.84 -9.23 -0.49 9.08e-18 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04346410 chr2:132238154 TUBA3D -0.52 -6.02 -0.35 5.72e-9 Gut microbiome composition (summer); CESC trans rs875971 0.895 rs12698520 chr7:65918707 C/A cg26939375 chr7:64535504 NA 0.47 6.01 0.35 5.95e-9 Aortic root size; CESC cis rs4253772 0.591 rs6007726 chr22:46650858 A/C cg09491104 chr22:46646882 C22orf40 -0.59 -9.15 -0.49 1.58e-17 LDL cholesterol;Cholesterol, total; CESC cis rs3782089 1.000 rs11600543 chr11:65298939 G/A cg00206168 chr11:65308501 LTBP3 1.0 6.54 0.37 3.15e-10 Height; CESC cis rs1355223 0.902 rs11819839 chr11:34715778 C/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.43 -0.37 6.04e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg11941060 chr3:133502564 NA 0.37 5.12 0.3 5.77e-7 Iron status biomarkers; CESC cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.86 8.98 0.48 5.03e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6541297 0.703 rs621328 chr1:230310414 G/A cg20703242 chr1:230279135 GALNT2 -0.44 -5.52 -0.32 7.95e-8 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07278332 chr7:94294290 PEG10 0.49 6.64 0.38 1.79e-10 Fibrinogen levels; CESC cis rs2204008 0.811 rs12368410 chr12:38305705 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.28 0.36 1.35e-9 Bladder cancer; CESC cis rs870825 0.616 rs4616798 chr4:185634144 C/T cg04058563 chr4:185651563 MLF1IP -0.64 -6.91 -0.39 3.59e-11 Blood protein levels; CESC cis rs67478160 0.619 rs55824307 chr14:104271207 C/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.09 -0.4 1.2e-11 Schizophrenia; CESC cis rs1878931 0.531 rs9635548 chr16:3417156 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.77 10.42 0.54 1.58e-21 Body mass index (adult); CESC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg24562669 chr7:97807699 LMTK2 0.52 7.6 0.42 5.03e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg05340658 chr4:99064831 C4orf37 0.77 11.85 0.59 2.88e-26 Colonoscopy-negative controls vs population controls; CESC cis rs2880765 0.743 rs8039631 chr15:86007931 A/G cg10818794 chr15:86012489 AKAP13 -0.33 -5.12 -0.3 6.02e-7 Coronary artery disease; CESC cis rs2439831 0.681 rs3742971 chr15:43622916 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.89 -10.82 -0.55 8.03e-23 Lung cancer in ever smokers; CESC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.55 -0.32 6.96e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6762 0.719 rs7936806 chr11:839186 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.74 -9.73 -0.51 2.49e-19 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09174855 chr19:1592510 MBD3 -0.64 -7.0 -0.4 2.15e-11 Gut microbiome composition (summer); CESC cis rs929354 0.772 rs6459741 chr7:157014553 G/T cg05182265 chr7:156933206 UBE3C -0.5 -7.39 -0.41 1.88e-12 Body mass index; CESC trans rs116095464 0.558 rs6555056 chr5:226222 T/C cg00938859 chr5:1591904 SDHAP3 0.61 6.84 0.39 5.52e-11 Breast cancer; CESC cis rs34779708 0.733 rs7081597 chr10:35546331 G/C cg03585969 chr10:35415529 CREM 0.56 6.54 0.37 3.17e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs6088590 0.610 rs6120663 chr20:33081906 A/C cg06115741 chr20:33292138 TP53INP2 -0.51 -6.63 -0.38 1.89e-10 Coronary artery disease; CESC cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg11812906 chr14:75593930 NEK9 0.83 13.51 0.64 5.28e-32 Height; CESC cis rs1707322 0.663 rs3935296 chr1:46180470 T/C cg03146154 chr1:46216737 IPP -0.82 -11.54 -0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs9858542 0.953 rs9821311 chr3:49543656 C/T cg21659725 chr3:3221576 CRBN -0.54 -6.37 -0.36 8.2e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs8114671 0.562 rs6087641 chr20:33467717 T/C cg06115741 chr20:33292138 TP53INP2 0.44 5.41 0.32 1.38e-7 Height; CESC cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.26 0.31 3e-7 Menopause (age at onset); CESC cis rs754466 0.580 rs11002294 chr10:79540588 T/C cg17075019 chr10:79541650 NA -0.88 -14.04 -0.65 7.39e-34 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs637571 0.524 rs674363 chr11:65699134 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.56 -6.95 -0.39 2.86e-11 Eosinophil percentage of white cells; CESC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.03 0.4 1.78e-11 Height; CESC trans rs11165623 0.740 rs12126692 chr1:96889258 C/G cg10631902 chr5:14652156 NA 0.55 8.15 0.45 1.45e-14 Hip circumference;Waist circumference; CESC trans rs9329221 0.683 rs4598253 chr8:9890304 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.27 -0.41 4.16e-12 Neuroticism; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09959495 chr2:237029385 AGAP1 -0.46 -6.03 -0.35 5.34e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs4974559 0.739 rs4333131 chr4:1323789 A/G cg02980000 chr4:1222292 CTBP1 0.69 7.76 0.43 1.86e-13 Systolic blood pressure; CESC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs3820068 0.705 rs57971278 chr1:15838604 G/A cg17385448 chr1:15911702 AGMAT 0.38 5.97 0.34 7.47e-9 Systolic blood pressure; CESC cis rs9300255 0.543 rs1617156 chr12:123590165 T/C cg19016782 chr12:123741754 C12orf65 -0.39 -5.08 -0.3 7.18e-7 Neutrophil percentage of white cells; CESC cis rs9910055 0.530 rs2269907 chr17:42294215 G/A cg19774624 chr17:42201019 HDAC5 -0.59 -8.54 -0.46 1.04e-15 Total body bone mineral density; CESC cis rs6546550 0.867 rs726920 chr2:70152027 G/C cg02498382 chr2:70120550 SNRNP27 -0.41 -7.25 -0.41 4.69e-12 Prevalent atrial fibrillation; CESC cis rs7605827 0.823 rs6431692 chr2:15478364 A/G cg19274914 chr2:15703543 NA 0.3 5.32 0.31 2.16e-7 Educational attainment (years of education); CESC cis rs9291683 0.632 rs7679916 chr4:10042160 C/T cg00071950 chr4:10020882 SLC2A9 0.83 14.41 0.66 3.63e-35 Bone mineral density; CESC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg24733560 chr20:60626293 TAF4 0.45 6.44 0.37 5.45e-10 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03925809 chr19:6393419 GTF2F1 -0.55 -6.32 -0.36 1.09e-9 Gut microbiome composition (summer); CESC cis rs9309711 0.961 rs11675119 chr2:3476422 C/A cg10845886 chr2:3471009 TTC15 -0.87 -12.48 -0.61 2.01e-28 Neurofibrillary tangles; CESC cis rs3820928 0.839 rs4675123 chr2:227800205 T/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.62 -0.33 4.72e-8 Pulmonary function; CESC cis rs734999 0.545 rs6698817 chr1:2564183 T/C cg18854424 chr1:2615690 NA -0.31 -5.91 -0.34 1.08e-8 Ulcerative colitis; CESC cis rs72627123 0.867 rs78742875 chr14:74457214 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.8 5.37 0.31 1.71e-7 Morning vs. evening chronotype; CESC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.27 -0.31 2.8e-7 Height; CESC cis rs2859741 0.507 rs564198 chr1:37467325 C/G cg09363841 chr1:37513479 NA -0.48 -6.21 -0.36 2.03e-9 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs734999 0.566 rs12748729 chr1:2558740 C/T cg18854424 chr1:2615690 NA -0.3 -5.83 -0.34 1.62e-8 Ulcerative colitis; CESC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg21017887 chr14:105400489 NA 0.41 6.57 0.37 2.6e-10 Rheumatoid arthritis; CESC cis rs3126085 0.935 rs2291770 chr1:152179792 G/C cg26876637 chr1:152193138 HRNR 0.48 5.44 0.32 1.21e-7 Atopic dermatitis; CESC trans rs7947523 0.813 rs4999940 chr11:80942337 C/T cg24701985 chr7:149535383 ZNF862 0.46 6.04 0.35 5.08e-9 Emphysema imaging phenotypes; CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg23161317 chr6:28129485 ZNF389 0.53 6.72 0.38 1.1e-10 Depression; CESC cis rs6964587 0.967 rs6973896 chr7:91778465 A/G cg17063962 chr7:91808500 NA 0.59 8.22 0.45 8.94e-15 Breast cancer; CESC cis rs2154427 0.938 rs114440021 chr21:34202672 C/T cg03746930 chr21:34165763 C21orf62;C21orf49 -0.53 -5.32 -0.31 2.17e-7 Bilirubin levels; CESC cis rs17376456 0.825 rs6898842 chr5:93213221 T/C cg25358565 chr5:93447407 FAM172A 1.11 10.53 0.54 6.8e-22 Diabetic retinopathy; CESC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg18350739 chr11:68623251 NA -0.38 -5.61 -0.33 5.08e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6456156 0.586 rs6909180 chr6:167460537 A/G cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.2e-10 Primary biliary cholangitis; CESC cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg17143192 chr8:8559678 CLDN23 0.78 8.81 0.48 1.63e-16 Obesity-related traits; CESC cis rs3092073 0.624 rs11696196 chr20:44574533 C/T cg27529037 chr20:44575021 PCIF1 0.64 9.71 0.51 2.97e-19 Intelligence (multi-trait analysis); CESC cis rs12900413 0.687 rs7176948 chr15:90315707 A/C cg24249390 chr15:90295951 MESP1 -0.41 -5.73 -0.33 2.78e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs9488822 0.676 rs11757115 chr6:116362619 C/T cg26893134 chr6:116381904 FRK 0.25 6.04 0.35 5.3300000000000004e-09 Cholesterol, total;LDL cholesterol; CESC cis rs7512552 0.839 rs1260459 chr1:150348253 T/G cg15654264 chr1:150340011 RPRD2 0.39 5.25 0.31 3.16e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg02592271 chr2:27665507 KRTCAP3 -0.3 -5.87 -0.34 1.32e-8 Total body bone mineral density; CESC cis rs11098499 0.954 rs2892848 chr4:120381341 C/T cg09307838 chr4:120376055 NA 0.95 13.8 0.65 5e-33 Corneal astigmatism; CESC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg18876405 chr7:65276391 NA 0.51 6.85 0.39 5.05e-11 Aortic root size; CESC cis rs11048434 0.736 rs11048190 chr12:9104939 C/T cg04155231 chr12:9217510 LOC144571 0.33 5.23 0.31 3.47e-7 Sjögren's syndrome; CESC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg06873352 chr17:61820015 STRADA -0.43 -6.29 -0.36 1.33e-9 Height; CESC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.51 0.37 3.65e-10 Prudent dietary pattern; CESC cis rs8070463 0.515 rs11655943 chr17:45385640 A/G cg25173405 chr17:45401733 C17orf57 -0.4 -5.09 -0.3 6.64e-7 Multiple sclerosis;Ankylosing spondylitis; CESC cis rs13223928 0.565 rs10240820 chr7:3154415 T/C cg19214707 chr7:3157722 NA -0.45 -6.05 -0.35 5.01e-9 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg07701084 chr6:150067640 NUP43 0.42 5.83 0.34 1.63e-8 Lung cancer; CESC cis rs977987 0.806 rs4888425 chr16:75476363 T/C cg03315344 chr16:75512273 CHST6 0.43 6.13 0.35 3.23e-9 Dupuytren's disease; CESC cis rs2180341 0.618 rs12210968 chr6:127596985 A/G cg27446573 chr6:127587934 RNF146 0.62 8.48 0.46 1.62e-15 Breast cancer; CESC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg18350739 chr11:68623251 NA -0.45 -6.37 -0.36 8.34e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13118159 0.641 rs4974598 chr4:1313220 C/T cg05025164 chr4:1340916 KIAA1530 0.54 7.4 0.41 1.85e-12 Longevity; CESC cis rs9649465 1.000 rs2299982 chr7:123356511 A/C cg04330084 chr7:123175371 IQUB -0.39 -5.23 -0.31 3.47e-7 Migraine; CESC cis rs116095464 0.558 rs61492827 chr5:225774 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.72 -0.47 3.15e-16 Breast cancer; CESC cis rs11252926 0.603 rs17293419 chr10:537014 G/A cg18196295 chr10:418757 DIP2C -0.5 -6.78 -0.38 7.57e-11 Psychosis in Alzheimer's disease; CESC cis rs9420 0.961 rs1647405 chr11:57477889 C/T cg23127183 chr11:57508653 C11orf31 -0.43 -5.14 -0.3 5.44e-7 Schizophrenia; CESC cis rs116095464 0.558 rs9687621 chr5:229194 C/T cg22857025 chr5:266934 NA -1.33 -14.37 -0.66 5.08e-35 Breast cancer; CESC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.77 6.63 0.38 1.87e-10 Platelet count; CESC cis rs79349575 0.783 rs9912829 chr17:46982749 G/C cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs5750830 0.594 rs9611166 chr22:39775268 T/C cg02038168 chr22:39784481 NA -0.56 -7.35 -0.41 2.5e-12 Intelligence (multi-trait analysis); CESC cis rs11122272 0.735 rs2749706 chr1:231527170 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.69 -0.43 2.92e-13 Hemoglobin concentration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07105891 chr1:21031312 KIF17 0.47 6.44 0.37 5.57e-10 Fibrinogen levels; CESC cis rs4900538 0.821 rs7012 chr14:102814945 C/T cg18135206 chr14:102964638 TECPR2 -0.68 -8.57 -0.47 8.46e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs9611565 0.512 rs9611672 chr22:42209922 A/G cg17376030 chr22:41985996 PMM1 0.77 7.96 0.44 5.16e-14 Vitiligo; CESC cis rs10242455 1.000 rs6948775 chr7:98945480 A/G cg05403484 chr7:98973169 ARPC1B -0.57 -5.14 -0.3 5.34e-7 Blood metabolite levels; CESC trans rs6429422 0.687 rs115012184 chr1:243304666 A/T cg10713773 chr13:51796714 FAM124A 0.46 6.17 0.35 2.56e-9 Cognitive ability (multi-trait analysis); CESC cis rs9308731 0.644 rs3789061 chr2:111918230 T/C cg04202892 chr2:111875749 ACOXL 0.44 6.34 0.36 9.87e-10 Chronic lymphocytic leukemia; CESC cis rs300703 0.719 rs385909 chr2:199678 A/G cg21211680 chr2:198530 NA 1.02 10.89 0.56 4.57e-23 Blood protein levels; CESC cis rs1538970 0.962 rs9429158 chr1:45821393 A/G cg06784218 chr1:46089804 CCDC17 0.3 5.05 0.3 8.3e-7 Platelet count; CESC cis rs854765 0.565 rs854768 chr17:18018806 T/C cg16928487 chr17:17741425 SREBF1 -0.47 -7.39 -0.41 1.92e-12 Total body bone mineral density; CESC cis rs2072499 0.966 rs1137703 chr1:156184458 T/C cg24450063 chr1:156163899 SLC25A44 1.07 20.83 0.79 9.98e-58 Testicular germ cell tumor; CESC cis rs1348850 0.554 rs7595576 chr2:178371921 C/T cg23306229 chr2:178417860 TTC30B 0.78 6.92 0.39 3.32e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1707322 0.963 rs1768815 chr1:46528603 G/A cg03146154 chr1:46216737 IPP -0.7 -9.19 -0.49 1.23e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg18402987 chr7:1209562 NA 0.56 6.65 0.38 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1552244 0.554 rs13079240 chr3:10047246 C/T cg00149659 chr3:10157352 C3orf10 0.54 6.55 0.37 2.98e-10 Alzheimer's disease; CESC cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.79 8.31 0.45 5.17e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs61542988 1.000 rs61542988 chr7:22882291 C/T cg13679077 chr7:22862647 TOMM7 0.51 6.29 0.36 1.34e-9 Fibrinogen levels; CESC cis rs5769765 1.000 rs2295409 chr22:50261060 G/C cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.28 0.31 2.69e-7 Schizophrenia; CESC cis rs2997447 0.761 rs72886625 chr1:26455319 A/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.16 0.3 4.76e-7 QRS complex (12-leadsum); CESC cis rs7772486 0.764 rs2265471 chr6:146220250 G/A cg23711669 chr6:146136114 FBXO30 0.88 12.96 0.62 4.27e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg18252515 chr7:66147081 NA -1.28 -12.48 -0.61 2.04e-28 Diabetic kidney disease; CESC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg04267008 chr7:1944627 MAD1L1 -0.58 -6.81 -0.39 6.69e-11 Bipolar disorder and schizophrenia; CESC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg22903471 chr2:27725779 GCKR -0.55 -7.81 -0.43 1.31e-13 Total body bone mineral density; CESC cis rs694739 0.628 rs645078 chr11:64135298 A/C cg02228329 chr11:64053129 BAD;GPR137 0.59 6.95 0.39 2.81e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs11640533 0.901 rs2908790 chr16:53412161 T/C cg04653913 chr16:53407753 NA 0.42 5.66 0.33 3.87e-8 Intelligence (multi-trait analysis); CESC cis rs75804782 0.641 rs72983861 chr2:239326126 G/A cg18131467 chr2:239335373 ASB1 -0.68 -5.62 -0.33 4.84e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs7208859 0.623 rs9911490 chr17:29073013 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -12.15 -0.6 2.74e-27 Alzheimer's disease; CESC cis rs698813 0.674 rs4953080 chr2:44500849 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.15 0.3 5.08e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs11792861 0.962 rs3750452 chr9:111801353 T/C cg14384093 chr9:111878565 C9orf5 -0.41 -5.16 -0.3 4.83e-7 Menarche (age at onset); CESC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg02569458 chr12:86230093 RASSF9 0.48 7.22 0.41 5.66e-12 Major depressive disorder; CESC cis rs11098499 0.954 rs13107475 chr4:120393011 A/T cg24375607 chr4:120327624 NA 0.45 5.7 0.33 3.16e-8 Corneal astigmatism; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg10568689 chr11:73591256 PAAF1 0.49 6.27 0.36 1.42e-9 Thyroid stimulating hormone; CESC cis rs7726839 0.561 rs4957049 chr5:579080 C/A cg09021430 chr5:549028 NA -0.44 -5.96 -0.34 8.23e-9 Obesity-related traits; CESC cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.73 10.79 0.55 9.56e-23 Hip circumference adjusted for BMI; CESC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.47 -6.79 -0.39 7.13e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01544351 chr19:46142757 MIR330;EML2 0.55 6.08 0.35 4.18e-9 Gut microbiome composition (summer); CESC cis rs977987 0.778 rs2113232 chr16:75391185 T/C cg03315344 chr16:75512273 CHST6 0.39 5.64 0.33 4.3e-8 Dupuytren's disease; CESC cis rs9790314 0.765 rs4856768 chr3:161004392 G/A cg04691961 chr3:161091175 C3orf57 -0.38 -5.06 -0.3 7.9e-7 Morning vs. evening chronotype; CESC cis rs11098499 0.863 rs13140391 chr4:120503437 A/G cg24375607 chr4:120327624 NA 0.46 5.47 0.32 1.05e-7 Corneal astigmatism; CESC trans rs208520 0.690 rs864314 chr6:66814830 G/T cg08225398 chr13:45563328 KIAA1704;NUFIP1 0.7 6.64 0.38 1.74e-10 Exhaled nitric oxide output; CESC cis rs1953600 0.870 rs12770550 chr10:81953451 G/T cg00277334 chr10:82204260 NA 0.46 6.41 0.37 6.68e-10 Sarcoidosis; CESC cis rs754466 0.651 rs11813532 chr10:79637991 T/C cg17075019 chr10:79541650 NA -0.86 -12.88 -0.62 8.37e-30 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs59918340 0.738 rs3739235 chr8:142229145 A/G cg16341495 chr8:142228727 SLC45A4 -0.44 -5.34 -0.31 1.98e-7 Immature fraction of reticulocytes; CESC cis rs2011503 0.941 rs55762233 chr19:19367319 C/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.48 5.09 0.3 6.95e-7 Bipolar disorder; CESC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg12463550 chr7:65579703 CRCP -0.52 -6.49 -0.37 4.08e-10 Aortic root size; CESC cis rs12912251 1.000 rs35102843 chr15:38988107 C/A cg01338139 chr15:38987640 C15orf53 -0.47 -5.43 -0.32 1.26e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs807669 0.903 rs1780637 chr22:19178250 A/G cg02655711 chr22:19163373 SLC25A1 0.96 14.54 0.67 1.32e-35 Metabolite levels; CESC cis rs6993244 1 rs6993244 chr8:8863059 C/G cg15556689 chr8:8085844 FLJ10661 0.45 5.89 0.34 1.19e-8 Mean corpuscular hemoglobin; CESC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg05564831 chr3:52568323 NT5DC2 0.45 7.15 0.4 8.3e-12 Bipolar disorder; CESC cis rs7089973 0.604 rs2420065 chr10:116583753 A/G cg03647239 chr10:116582469 FAM160B1 0.42 5.13 0.3 5.48e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs8180040 0.620 rs17784127 chr3:47061700 T/C cg27129171 chr3:47204927 SETD2 -0.66 -9.85 -0.52 1.04e-19 Colorectal cancer; CESC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.92 0.52 6.43e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs965469 0.895 rs6139123 chr20:3396634 C/T cg25506879 chr20:3388711 C20orf194 -0.63 -6.6 -0.38 2.24e-10 IFN-related cytopenia; CESC cis rs2204008 0.744 rs11168870 chr12:37973333 A/G cg13010199 chr12:38710504 ALG10B 0.53 6.61 0.38 2.1e-10 Bladder cancer; CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg24503407 chr1:205819492 PM20D1 0.87 15.57 0.69 2.98e-39 Menarche (age at onset); CESC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg27165867 chr14:105738592 BRF1 -0.49 -5.29 -0.31 2.59e-7 Mean platelet volume;Platelet distribution width; CESC cis rs3747547 0.818 rs16934639 chr9:37943092 T/C cg13774184 chr9:37916125 SHB -0.54 -5.58 -0.32 5.79e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg18446336 chr7:2847575 GNA12 -0.4 -5.97 -0.34 7.59e-9 Height; CESC cis rs1443512 0.812 rs2078098 chr12:54337527 C/A cg12374095 chr12:54320830 NA -0.44 -6.1 -0.35 3.65e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs4523957 0.928 rs4790325 chr17:2192085 C/T cg16513277 chr17:2031491 SMG6 -0.59 -8.08 -0.44 2.29e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7953249 0.514 rs1169312 chr12:121441461 G/T cg25281562 chr12:121454272 C12orf43 0.39 5.09 0.3 6.73e-7 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg21770322 chr7:97807741 LMTK2 0.57 8.68 0.47 4.01e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs4727027 0.899 rs4727025 chr7:148862863 A/G cg23583168 chr7:148888333 NA -0.81 -12.68 -0.61 4.05e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1865721 0.804 rs7243462 chr18:73147998 A/T cg26385618 chr18:73139727 C18orf62 -0.52 -8.04 -0.44 2.92e-14 Intelligence; CESC cis rs6988985 0.560 rs4418320 chr8:143944138 G/A cg10324643 chr8:143916377 GML 0.34 5.08 0.3 7.1e-7 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CESC cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg09455208 chr3:40491958 NA 0.5 8.94 0.48 6.79e-17 Renal cell carcinoma; CESC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC cis rs599083 0.530 rs576118 chr11:68177708 C/T cg16797656 chr11:68205561 LRP5 -0.38 -5.17 -0.3 4.61e-7 Bone mineral density (spine); CESC cis rs863345 0.625 rs11265006 chr1:158498485 C/G cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.54e-11 Pneumococcal bacteremia; CESC cis rs2573652 0.722 rs12595247 chr15:100541689 C/T cg09918751 chr15:100517450 ADAMTS17 -0.33 -6.17 -0.35 2.55e-9 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08886844 chr19:8373286 CD320 -0.48 -6.21 -0.36 2.05e-9 Fibrinogen levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg06766450 chr1:16766999 NECAP2 -0.45 -6.09 -0.35 4.06e-9 Height; CESC cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg22823121 chr1:150693482 HORMAD1 -0.36 -5.28 -0.31 2.65e-7 Tonsillectomy; CESC trans rs208520 0.526 rs9354366 chr6:66788559 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -24.71 -0.84 9.81e-71 Exhaled nitric oxide output; CESC cis rs10927875 0.526 rs2179615 chr1:16282426 G/A cg21385522 chr1:16154831 NA -0.88 -9.73 -0.51 2.53e-19 Dilated cardiomyopathy; CESC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg00802000 chr16:706648 WDR90 -0.43 -6.57 -0.37 2.64e-10 Height; CESC cis rs4790312 0.935 rs3744274 chr17:1990959 G/T cg20777128 chr17:1945076 DPH1;OVCA2 -0.42 -5.04 -0.3 8.83e-7 Left atrial antero-posterior diameter; CESC cis rs611744 0.647 rs628206 chr8:109247873 A/G cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.65e-8 Dupuytren's disease; CESC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg11859384 chr17:80120422 CCDC57 0.4 5.5 0.32 8.88e-8 Life satisfaction; CESC cis rs6866344 0.697 rs17184281 chr5:178127563 G/A cg03877680 chr5:178157825 ZNF354A 0.77 8.67 0.47 4.29e-16 Neutrophil percentage of white cells; CESC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg14773178 chr5:1868261 NA 0.32 5.68 0.33 3.53e-8 Cardiovascular disease risk factors; CESC cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg23018236 chr17:30244563 NA -0.54 -5.27 -0.31 2.78e-7 Hip circumference adjusted for BMI; CESC cis rs1559088 0.600 rs58173463 chr19:33596749 C/T cg03563238 chr19:33554763 RHPN2 -0.32 -5.87 -0.34 1.28e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9790314 0.663 rs796609 chr3:160705600 C/G cg04691961 chr3:161091175 C3orf57 -0.38 -5.03 -0.3 9.05e-7 Morning vs. evening chronotype; CESC cis rs2243480 0.901 rs35256305 chr7:65306405 T/C cg13147721 chr7:65941812 NA -0.85 -8.51 -0.46 1.26e-15 Diabetic kidney disease; CESC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg23590916 chr17:43697445 MGC57346 0.65 6.48 0.37 4.51e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11077998 0.967 rs7502945 chr17:80495039 T/C cg10255544 chr17:80519551 FOXK2 0.54 8.75 0.47 2.59e-16 Reticulocyte fraction of red cells; CESC cis rs5758659 1.000 rs134882 chr22:42670965 A/G cg04733989 chr22:42467013 NAGA 0.4 5.54 0.32 7.36e-8 Cognitive function; CESC cis rs6570726 0.905 rs442435 chr6:145815559 C/T cg23711669 chr6:146136114 FBXO30 0.77 11.31 0.57 1.91e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg13206674 chr6:150067644 NUP43 0.46 6.73 0.38 1.03e-10 Lung cancer; CESC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg12463550 chr7:65579703 CRCP 0.59 7.52 0.42 8.29e-13 Aortic root size; CESC cis rs6076065 0.748 rs6048784 chr20:23382652 A/T cg11657817 chr20:23433608 CST11 0.4 6.1 0.35 3.7e-9 Facial morphology (factor 15, philtrum width); CESC cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.95 -19.25 -0.76 2.89e-52 Birth weight; CESC cis rs9916302 0.904 rs11078915 chr17:37715426 T/C cg00129232 chr17:37814104 STARD3 -0.57 -7.46 -0.42 1.22e-12 Glomerular filtration rate (creatinine); CESC cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg02297831 chr4:17616191 MED28 0.52 5.98 0.34 7.1e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07136949 chr6:7986672 MGC26597 -0.64 -7.95 -0.44 5.31e-14 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22242926 chr17:73627717 RECQL5 0.45 6.3 0.36 1.23e-9 Fibrinogen levels; CESC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg22433210 chr17:43662623 NA 0.94 10.47 0.54 1.07e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6540559 0.673 rs17015330 chr1:210012795 T/G cg21951975 chr1:209979733 IRF6 0.54 6.54 0.37 3.19e-10 Cleft lip with or without cleft palate; CESC cis rs7264396 0.563 rs2425109 chr20:34316218 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.79 0.39 7.19e-11 Total cholesterol levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14839808 chr12:28343774 NA -0.5 -6.93 -0.39 3.25e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg02079420 chr8:82753780 SNX16 0.5 7.56 0.42 6.82e-13 Diastolic blood pressure; CESC cis rs13385 0.769 rs28450136 chr5:139598090 A/G cg26211634 chr5:139558579 C5orf32 0.46 5.12 0.3 5.97e-7 Atrial fibrillation; CESC cis rs3820068 0.705 rs72645803 chr1:15868232 G/A cg17385448 chr1:15911702 AGMAT 0.38 5.9 0.34 1.1e-8 Systolic blood pressure; CESC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg26818010 chr10:134567672 INPP5A -0.9 -11.15 -0.56 6.51e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9611565 0.546 rs5758431 chr22:42109917 A/G cg06634786 chr22:41940651 POLR3H 0.66 6.76 0.38 8.7e-11 Vitiligo; CESC cis rs2228479 0.618 rs72477006 chr16:89950299 G/C cg06558623 chr16:89946397 TCF25 1.03 8.33 0.46 4.25e-15 Skin colour saturation; CESC cis rs11690935 0.632 rs12998411 chr2:172530707 G/C cg13550731 chr2:172543902 DYNC1I2 0.57 7.98 0.44 4.34e-14 Schizophrenia; CESC cis rs2412459 0.536 rs7173301 chr15:40269843 C/T cg25407064 chr15:40226267 EIF2AK4 0.55 5.54 0.32 7.3e-8 Response to haloperidol in psychosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01663295 chr11:65837194 PACS1 0.5 6.85 0.39 5.11e-11 Gut microbiota (bacterial taxa); CESC cis rs910316 1.000 rs4903281 chr14:75554361 G/C cg08847533 chr14:75593920 NEK9 1.0 19.06 0.76 1.38e-51 Height; CESC cis rs2108225 0.900 rs2395930 chr7:107451677 T/C cg18560240 chr7:107437656 SLC26A3 -0.4 -5.4 -0.31 1.51e-7 Ulcerative colitis; CESC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg23281280 chr6:28129359 ZNF389 0.59 7.91 0.44 7.14e-14 Depression; CESC cis rs4835473 0.592 rs11100825 chr4:144886056 G/A cg25736465 chr4:144833511 NA 0.41 6.25 0.36 1.64e-9 Immature fraction of reticulocytes; CESC cis rs929354 0.713 rs6946660 chr7:156948648 T/C cg05182265 chr7:156933206 UBE3C -0.5 -7.29 -0.41 3.49e-12 Body mass index; CESC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg25072359 chr17:41440525 NA 0.47 6.36 0.36 8.86e-10 Menopause (age at onset); CESC cis rs6076065 0.748 rs6048750 chr20:23334192 T/G cg11657817 chr20:23433608 CST11 0.41 6.23 0.36 1.83e-9 Facial morphology (factor 15, philtrum width); CESC cis rs7223966 1.000 rs78172786 chr17:61847114 A/C cg11494091 chr17:61959527 GH2 0.4 5.32 0.31 2.25e-7 Hip circumference adjusted for BMI;Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24054683 chr1:2085751 PRKCZ -0.56 -6.07 -0.35 4.49e-9 Gut microbiome composition (summer); CESC cis rs7107174 0.901 rs901105 chr11:77924607 A/C cg02023728 chr11:77925099 USP35 0.47 5.97 0.34 7.71e-9 Testicular germ cell tumor; CESC cis rs7246865 0.906 rs11666569 chr19:17214073 A/G cg16202187 chr19:17186497 HAUS8;MYO9B -0.41 -5.03 -0.3 8.99e-7 Reticulocyte fraction of red cells; CESC cis rs763121 0.776 rs4820346 chr22:39125074 C/G cg06022373 chr22:39101656 GTPBP1 -0.89 -14.0 -0.65 1.05e-33 Menopause (age at onset); CESC cis rs9486719 0.790 rs2499790 chr6:96845078 G/A cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg20203395 chr5:56204925 C5orf35 -0.42 -5.05 -0.3 8.07e-7 Initial pursuit acceleration; CESC cis rs2806561 0.929 rs6660880 chr1:23540302 T/C cg12483005 chr1:23474871 LUZP1 -0.33 -5.33 -0.31 2.07e-7 Height; CESC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg06420487 chr17:61919686 SMARCD2 0.42 5.12 0.3 5.95e-7 Height; CESC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.91 0.34 1.03e-8 Tonsillectomy; CESC trans rs3780486 0.505 rs10117038 chr9:33122626 T/C cg20290983 chr6:43655470 MRPS18A 0.76 12.11 0.6 3.58e-27 IgG glycosylation; CESC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg19318889 chr4:1322082 MAEA -0.46 -6.0 -0.35 6.58e-9 Obesity-related traits; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg02604939 chr3:50330083 IFRD2 0.45 6.03 0.35 5.56e-9 Thyroid stimulating hormone; CESC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg01411255 chr17:61851458 DDX42;CCDC47 1.11 19.57 0.77 2.18e-53 Height; CESC cis rs9300255 0.568 rs1627724 chr12:123638580 T/A cg00376283 chr12:123451042 ABCB9 0.7 8.89 0.48 9.5e-17 Neutrophil percentage of white cells; CESC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg22920501 chr2:26401640 FAM59B -0.64 -7.67 -0.43 3.37e-13 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg24209194 chr3:40518798 ZNF619 0.5 6.12 0.35 3.3e-9 Renal cell carcinoma; CESC trans rs561341 1.000 rs111454793 chr17:30319267 T/C cg20587970 chr11:113659929 NA -1.42 -18.3 -0.75 6.25e-49 Hip circumference adjusted for BMI; CESC cis rs10752881 0.905 rs10797830 chr1:183036274 A/T ch.1.3577855R chr1:183094577 LAMC1 0.87 13.77 0.65 6.86e-33 Colorectal cancer; CESC cis rs6459788 0.502 rs9692347 chr7:157232659 C/T cg06271696 chr7:157225062 NA -0.46 -7.71 -0.43 2.6e-13 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs9300255 0.602 rs2695476 chr12:123694206 T/C cg00376283 chr12:123451042 ABCB9 0.61 6.37 0.36 8.43e-10 Neutrophil percentage of white cells; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg21547979 chr19:49141364 SEC1;DBP;CA11 0.46 6.23 0.36 1.84e-9 Retinol levels; CESC cis rs6088580 0.634 rs6059824 chr20:33014543 T/C cg08999081 chr20:33150536 PIGU 0.66 11.54 0.58 3.17e-25 Glomerular filtration rate (creatinine); CESC cis rs3126085 0.935 rs4845736 chr1:152175551 G/A cg26876637 chr1:152193138 HRNR 0.45 5.2 0.3 3.98e-7 Atopic dermatitis; CESC cis rs7264396 0.563 rs2425090 chr20:34304783 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.7 0.38 1.23e-10 Total cholesterol levels; CESC cis rs2320614 0.806 rs17471740 chr4:164100276 C/T cg15586945 chr4:164088095 NAF1 -0.47 -5.91 -0.34 1.05e-8 Lung adenocarcinoma; CESC cis rs6991838 0.612 rs7832407 chr8:66533306 C/T cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs4803468 1.000 rs10422783 chr19:41906436 T/C cg09537434 chr19:41945824 ATP5SL -1.06 -19.22 -0.76 3.86e-52 Height; CESC cis rs6063312 0.667 rs9679994 chr20:47281853 T/C cg18078177 chr20:47281410 PREX1 0.67 8.56 0.47 9.44e-16 Tonometry; CESC trans rs7307889 0.793 rs12301367 chr12:6009024 C/T cg18407955 chr7:158110685 PTPRN2 -0.72 -6.66 -0.38 1.53e-10 Obesity-related traits; CESC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg00074818 chr8:8560427 CLDN23 0.36 5.29 0.31 2.51e-7 Obesity-related traits; CESC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg04414720 chr1:150670196 GOLPH3L 0.45 5.96 0.34 8.13e-9 Melanoma; CESC cis rs2439831 1.000 rs527921 chr15:43770416 G/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.89 -10.44 -0.54 1.31e-21 Lung cancer in ever smokers; CESC cis rs244293 0.730 rs9898020 chr17:53057715 G/A cg19360675 chr17:53046073 COX11;STXBP4 -0.46 -6.1 -0.35 3.71e-9 Menarche (age at onset); CESC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg06601766 chr17:61851465 DDX42;CCDC47 -0.77 -10.12 -0.53 1.47e-20 Height; CESC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg18350739 chr11:68623251 NA -0.45 -6.88 -0.39 4.4e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11122272 0.735 rs2486734 chr1:231531392 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs10905065 0.804 rs2380202 chr10:5823397 C/T cg11519256 chr10:5708881 ASB13 -0.39 -5.12 -0.3 5.79e-7 Menopause (age at onset); CESC cis rs8072100 0.713 rs9895776 chr17:45486003 A/G cg08085267 chr17:45401833 C17orf57 -0.52 -6.64 -0.38 1.81e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg13834670 chr9:129677390 RALGPS1 0.46 6.32 0.36 1.08e-9 Breast cancer;Type 2 diabetes; CESC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg11764359 chr7:65958608 NA 0.91 13.19 0.63 7.05e-31 Aortic root size; CESC cis rs3733585 0.534 rs7375642 chr4:9955236 A/G cg11266682 chr4:10021025 SLC2A9 -0.57 -10.92 -0.56 3.75e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4253772 0.591 rs8143066 chr22:46656607 C/T cg09491104 chr22:46646882 C22orf40 -0.6 -9.36 -0.5 3.69e-18 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.92 -0.52 6.14e-20 Developmental language disorder (linguistic errors); CESC cis rs7605378 1.000 rs796363 chr2:200693668 T/C cg23649088 chr2:200775458 C2orf69 0.5 6.65 0.38 1.66e-10 Osteoporosis; CESC cis rs642803 0.613 rs565427 chr11:65532825 G/A cg02870584 chr11:65547924 DKFZp761E198 0.53 6.65 0.38 1.65e-10 Urate levels; CESC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg10295955 chr4:187884368 NA -1.08 -23.01 -0.82 4.07e-65 Lobe attachment (rater-scored or self-reported); CESC cis rs1801251 0.893 rs6733151 chr2:233592341 A/C cg25237894 chr2:233734115 C2orf82 0.46 7.86 0.43 9.9e-14 Coronary artery disease; CESC cis rs79349575 0.783 rs62078370 chr17:47026836 G/C cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg09658497 chr7:2847517 GNA12 -0.42 -5.86 -0.34 1.37e-8 Height; CESC cis rs2070677 0.935 rs12245492 chr10:135419727 A/G cg20169779 chr10:135381914 SYCE1 -0.73 -9.56 -0.51 8.51e-19 Gout; CESC cis rs2273669 0.667 rs12374658 chr6:109345930 T/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11038604 chr10:14996337 DCLRE1C -0.58 -6.6 -0.38 2.29e-10 Gut microbiome composition (summer); CESC cis rs12893668 0.667 rs11844466 chr14:104066422 G/A cg08213375 chr14:104286397 PPP1R13B 0.32 5.1 0.3 6.33e-7 Reticulocyte count; CESC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg09323728 chr8:95962352 TP53INP1 -0.38 -8.37 -0.46 3.31e-15 Type 2 diabetes; CESC cis rs733175 0.951 rs6846692 chr4:10031133 C/G cg00071950 chr4:10020882 SLC2A9 0.45 5.15 0.3 5.06e-7 Psychosis and Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04765098 chr4:184644154 NA 0.57 6.58 0.37 2.49e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.84e-7 Gut microbiome composition (summer); CESC trans rs1557351 0.602 rs948650 chr18:54721870 G/A cg11433624 chr6:7146702 RREB1 0.38 6.14 0.35 2.94e-9 Multiple sclerosis (age of onset); CESC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg07870213 chr5:140052090 DND1 0.64 6.81 0.39 6.47e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7809950 0.678 rs7777950 chr7:107004672 T/C cg23024343 chr7:107201750 COG5 -0.52 -6.72 -0.38 1.08e-10 Coronary artery disease; CESC cis rs4642101 0.597 rs9865624 chr3:12822786 T/A cg24848339 chr3:12840334 CAND2 0.39 5.96 0.34 8.16e-9 QRS complex (12-leadsum); CESC cis rs7917772 0.503 rs11191347 chr10:104351617 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.35 -0.36 9.36e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs16858210 0.874 rs55666767 chr3:183573235 C/T cg25686905 chr3:183603175 PARL -0.33 -5.98 -0.34 7.2e-9 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14659771 chr2:231917362 NA -0.44 -6.11 -0.35 3.64e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg01516881 chr6:292596 DUSP22 -0.52 -6.92 -0.39 3.43e-11 Menopause (age at onset); CESC cis rs738322 1.000 rs4379 chr22:38569171 T/C cg17652424 chr22:38574118 PLA2G6 -0.34 -6.03 -0.35 5.53e-9 Cutaneous nevi; CESC cis rs7828089 0.561 rs13266541 chr8:22266135 G/A cg12081754 chr8:22256438 SLC39A14 0.62 8.72 0.47 3.21e-16 Verbal declarative memory; CESC cis rs7980687 0.596 rs1727319 chr12:123701353 T/C cg19016782 chr12:123741754 C12orf65 -0.34 -5.1 -0.3 6.57e-7 Height;Educational attainment;Head circumference (infant); CESC cis rs933688 1.000 rs61612071 chr5:90741470 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 11.04 0.56 1.47e-23 Smoking behavior; CESC cis rs17253792 0.908 rs9972177 chr14:56073206 G/A cg01858014 chr14:56050164 KTN1 -0.83 -7.03 -0.4 1.7e-11 Putamen volume; CESC cis rs763121 0.853 rs3788545 chr22:39065172 A/G cg06544989 chr22:39130855 UNC84B 0.5 8.61 0.47 6.7e-16 Menopause (age at onset); CESC trans rs6763848 0.545 rs2648451 chr3:1525557 C/T cg08653403 chr1:16212402 SPEN -0.39 -6.08 -0.35 4.09e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1949733 0.701 rs871768 chr4:8454938 G/A cg11789530 chr4:8429930 ACOX3 0.76 11.12 0.56 8.15e-24 Response to antineoplastic agents; CESC cis rs7188873 1 rs7188873 chr16:24727064 A/G cg06028605 chr16:24865363 SLC5A11 -0.34 -5.26 -0.31 2.97e-7 Intelligence (multi-trait analysis); CESC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6570726 0.935 rs408768 chr6:145871735 A/G cg05347473 chr6:146136440 FBXO30 0.48 6.49 0.37 4.11e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs3540 0.554 rs34650360 chr15:91059017 T/C cg10434728 chr15:90938212 IQGAP1 -0.4 -6.97 -0.39 2.48e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs55728055 0.661 rs62239172 chr22:32047941 G/A cg01338084 chr22:32026380 PISD 1.29 8.72 0.47 3.17e-16 Age-related hearing impairment; CESC cis rs8020095 0.528 rs73279056 chr14:67701536 T/G cg19548862 chr14:67692701 FAM71D -0.47 -5.66 -0.33 4.01e-8 Depression (quantitative trait); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21186779 chr16:46462885 NA -0.61 -6.81 -0.39 6.46e-11 Gut microbiome composition (summer); CESC cis rs752092 0.894 rs8042989 chr15:101770761 T/A cg19997662 chr15:101784653 CHSY1 -0.42 -5.48 -0.32 1e-7 Corneal structure; CESC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg08736216 chr1:53307985 ZYG11A 0.43 7.24 0.41 4.72e-12 Monocyte count; CESC cis rs4819052 0.851 rs2838866 chr21:46713014 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 11.93 0.59 1.56e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2288073 0.896 rs13404513 chr2:24410780 G/A cg06627628 chr2:24431161 ITSN2 -0.74 -8.68 -0.47 4.02e-16 Venous thromboembolism (SNP x SNP interaction); CESC cis rs11122272 0.735 rs2491404 chr1:231512127 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs7098414 0.511 rs7907575 chr10:82152675 T/G cg00277334 chr10:82204260 NA -0.5 -7.37 -0.41 2.23e-12 Post bronchodilator FEV1; CESC cis rs7508679 1.000 rs10401485 chr19:7222234 T/C cg00428638 chr19:7224713 INSR 0.47 7.42 0.41 1.56e-12 Hypothyroidism; CESC cis rs9420 0.816 rs674094 chr11:57665336 A/C cg23127183 chr11:57508653 C11orf31 0.48 5.11 0.3 6.08e-7 Schizophrenia; CESC cis rs714031 0.934 rs738315 chr22:40069245 T/C cg21377881 chr22:40064566 CACNA1I -0.32 -5.1 -0.3 6.38e-7 Schizophrenia; CESC cis rs854765 0.647 rs9303144 chr17:17977355 T/C cg16928487 chr17:17741425 SREBF1 -0.52 -8.4 -0.46 2.72e-15 Total body bone mineral density; CESC trans rs1493916 0.870 rs8097667 chr18:31387003 C/T cg27147174 chr7:100797783 AP1S1 -0.49 -6.81 -0.39 6.62e-11 Life satisfaction; CESC cis rs72781680 1.000 rs6731001 chr2:24192952 A/G cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.56e-8 Lymphocyte counts; CESC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg11663144 chr21:46675770 NA -0.63 -9.99 -0.52 3.64e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg23161317 chr6:28129485 ZNF389 0.38 5.05 0.3 8.16e-7 Cardiac Troponin-T levels; CESC trans rs1829883 0.514 rs62375908 chr5:98753389 G/A cg23861655 chr4:57411219 NA 0.39 6.32 0.36 1.1e-9 Hemostatic factors and hematological phenotypes; CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg18402987 chr7:1209562 NA 0.44 5.8 0.34 1.86e-8 Longevity;Endometriosis; CESC cis rs9768139 0.733 rs34173461 chr7:158122175 C/G cg06219351 chr7:158114137 PTPRN2 -0.51 -7.88 -0.44 8.68e-14 Calcium levels; CESC cis rs1847202 1.000 rs6807627 chr3:72939767 C/T cg25664220 chr3:72788482 NA -0.36 -5.4 -0.31 1.46e-7 Motion sickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17890828 chr19:36103534 HAUS5 0.61 7.21 0.4 5.75e-12 Gut microbiome composition (summer); CESC cis rs59918340 0.764 rs753779 chr8:142228809 T/C cg23750338 chr8:142222470 SLC45A4 0.62 9.26 0.49 7.46e-18 Immature fraction of reticulocytes; CESC cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg19539972 chr4:7069911 GRPEL1 0.78 10.38 0.54 2.04e-21 Monocyte percentage of white cells; CESC cis rs5743618 0.537 rs11734337 chr4:38773067 A/G cg02016764 chr4:38805732 TLR1 -0.33 -5.15 -0.3 4.97e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs2243480 1.000 rs35825738 chr7:65318027 A/G cg13147721 chr7:65941812 NA -0.85 -8.51 -0.46 1.26e-15 Diabetic kidney disease; CESC cis rs36051895 0.659 rs59668095 chr9:5043688 C/G cg02405213 chr9:5042618 JAK2 -0.49 -5.84 -0.34 1.55e-8 Pediatric autoimmune diseases; CESC cis rs5750830 0.594 rs9611166 chr22:39775268 T/C cg05872129 chr22:39784769 NA -0.75 -10.71 -0.55 1.76e-22 Intelligence (multi-trait analysis); CESC trans rs3780486 0.846 rs7850878 chr9:33126570 A/G cg04842962 chr6:43655489 MRPS18A 1.0 19.21 0.76 4.11e-52 IgG glycosylation; CESC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.42 -6.98 -0.39 2.33e-11 Personality dimensions; CESC cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg05347473 chr6:146136440 FBXO30 -0.57 -7.25 -0.41 4.46e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs17384381 0.861 rs12736004 chr1:85901367 G/A cg16011679 chr1:85725395 C1orf52 0.74 7.49 0.42 1.04e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg00129232 chr17:37814104 STARD3 0.59 7.81 0.43 1.3e-13 Glomerular filtration rate (creatinine); CESC cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg03060546 chr3:49711283 APEH 0.45 5.5 0.32 9e-8 Parkinson's disease; CESC cis rs72781680 0.752 rs56343114 chr2:23900629 C/G cg20701182 chr2:24300061 SF3B14 0.72 6.32 0.36 1.09e-9 Lymphocyte counts; CESC cis rs6964587 1.000 rs2106171 chr7:91750450 A/G cg17063962 chr7:91808500 NA 0.58 8.02 0.44 3.33e-14 Breast cancer; CESC cis rs712039 0.652 rs1102920 chr17:35760940 A/G cg16670864 chr17:35848621 DUSP14 0.48 6.12 0.35 3.34e-9 Tuberculosis; CESC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg15445000 chr17:37608096 MED1 -0.42 -6.67 -0.38 1.49e-10 Glomerular filtration rate (creatinine); CESC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg18876405 chr7:65276391 NA 0.69 9.72 0.51 2.78e-19 Aortic root size; CESC cis rs4654899 0.758 rs6698462 chr1:21341293 G/C cg05370193 chr1:21551575 ECE1 0.37 5.65 0.33 4.12e-8 Superior frontal gyrus grey matter volume; CESC cis rs12410462 0.581 rs6675521 chr1:227544702 C/T cg10327440 chr1:227177885 CDC42BPA -0.67 -5.69 -0.33 3.43e-8 Major depressive disorder; CESC cis rs2191566 0.576 rs436790 chr19:44491927 A/G cg20607764 chr19:44506953 ZNF230 -0.43 -5.31 -0.31 2.29e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs9768139 0.935 rs7809076 chr7:158118438 C/T cg25566285 chr7:158114605 PTPRN2 -0.49 -8.31 -0.45 4.93e-15 Calcium levels; CESC cis rs7927771 0.697 rs11039307 chr11:47611152 C/T cg18512352 chr11:47633146 NA -0.46 -7.06 -0.4 1.44e-11 Subjective well-being; CESC trans rs561341 0.941 rs4525554 chr17:30312819 T/C cg27661571 chr11:113659931 NA -0.83 -7.76 -0.43 1.9e-13 Hip circumference adjusted for BMI; CESC cis rs3204270 0.714 rs8074828 chr17:79657136 G/C cg26965718 chr17:79658957 HGS -0.76 -5.67 -0.33 3.81e-8 Dental caries; CESC cis rs8077577 0.708 rs3862147 chr17:18133713 G/T cg16794390 chr17:18148240 FLII -0.45 -6.69 -0.38 1.35e-10 Obesity-related traits; CESC cis rs863345 0.901 rs1342956 chr1:158467755 A/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.27 -0.36 1.42e-9 Pneumococcal bacteremia; CESC cis rs2439831 1.000 rs2444029 chr15:43737484 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.63 0.55 3.35e-22 Lung cancer in ever smokers; CESC cis rs7116495 0.619 rs7116188 chr11:71841753 A/G cg26138937 chr11:71823887 C11orf51 0.77 6.17 0.35 2.58e-9 Severe influenza A (H1N1) infection; CESC cis rs2295499 0.643 rs59609182 chr4:2721530 C/T cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.32 -0.31 2.21e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg25036284 chr2:26402008 FAM59B -0.75 -7.88 -0.44 8.74e-14 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs160655 chr7:65533214 T/C cg18252515 chr7:66147081 NA -1.33 -13.56 -0.64 3.72e-32 Diabetic kidney disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15901550 chr1:17997619 ARHGEF10L -0.45 -6.27 -0.36 1.44e-9 Asthma; CESC cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg16405210 chr4:1374714 KIAA1530 -0.57 -7.51 -0.42 8.89e-13 Longevity; CESC cis rs1878931 0.567 rs7196196 chr16:3411855 C/A cg22508957 chr16:3507546 NAT15 -0.36 -5.17 -0.3 4.68e-7 Body mass index (adult); CESC cis rs2011503 0.891 rs2965190 chr19:19451591 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.51 -5.13 -0.3 5.64e-7 Bipolar disorder; CESC cis rs5758511 0.680 rs5758692 chr22:42669029 T/A cg00645731 chr22:42541494 CYP2D7P1 0.59 8.55 0.47 9.64e-16 Birth weight; CESC cis rs4588572 0.601 rs1529500 chr5:77721643 C/T cg11547950 chr5:77652471 NA -0.45 -5.65 -0.33 4.15e-8 Triglycerides; CESC trans rs9467711 0.606 rs9358930 chr6:26357011 C/T cg06606381 chr12:133084897 FBRSL1 -0.76 -6.87 -0.39 4.66e-11 Autism spectrum disorder or schizophrenia; CESC cis rs478304 0.651 rs11600918 chr11:65511965 A/G cg10518572 chr11:65560635 OVOL1 -0.32 -6.12 -0.35 3.44e-9 Acne (severe); CESC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg07256732 chr16:621771 PIGQ -0.3 -5.25 -0.31 3.09e-7 Height; CESC cis rs3749237 0.595 rs3924462 chr3:49524236 T/G cg07636037 chr3:49044803 WDR6 0.61 8.81 0.48 1.66e-16 Resting heart rate; CESC cis rs11098499 0.754 rs2964 chr4:120240131 T/C cg09307838 chr4:120376055 NA 0.79 10.77 0.55 1.17e-22 Corneal astigmatism; CESC cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg01579765 chr21:45077557 HSF2BP -0.55 -9.61 -0.51 6.1e-19 Mean corpuscular volume; CESC cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg05340658 chr4:99064831 C4orf37 0.74 10.76 0.55 1.18e-22 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg06634786 chr22:41940651 POLR3H -0.7 -7.42 -0.41 1.63e-12 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20879272 chr20:3996372 RNF24 0.56 6.06 0.35 4.69e-9 Gut microbiome composition (summer); CESC cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg02935154 chr7:12443704 VWDE -0.56 -5.88 -0.34 1.24e-8 Coronary artery disease; CESC cis rs10504073 0.605 rs62507176 chr8:49930321 G/A cg00325661 chr8:49890786 NA 0.55 8.31 0.45 5.1e-15 Blood metabolite ratios; CESC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs412050 0.547 rs17821500 chr22:22152480 T/C cg17089214 chr22:22089827 YPEL1 0.67 5.8 0.34 1.92e-8 Attention deficit hyperactivity disorder; CESC cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9837602 1.000 rs9841186 chr3:99795651 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -6.43 -0.37 6.02e-10 Breast cancer; CESC cis rs7100689 0.754 rs10736339 chr10:82059970 G/C cg09936400 chr10:82049201 MAT1A 0.37 5.31 0.31 2.34e-7 Post bronchodilator FEV1; CESC cis rs9309473 1.000 rs7572722 chr2:73724675 T/C cg20560298 chr2:73613845 ALMS1 -0.55 -7.15 -0.4 8.23e-12 Metabolite levels; CESC cis rs1594829 0.535 rs11784209 chr8:26170246 T/C cg11498726 chr8:26250323 BNIP3L -0.41 -6.2 -0.36 2.2e-9 Height; CESC cis rs72781680 0.566 rs55987381 chr2:23900938 T/C cg20701182 chr2:24300061 SF3B14 0.71 7.18 0.4 7.24e-12 Lymphocyte counts; CESC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg17178900 chr1:205818956 PM20D1 0.39 5.08 0.3 7.01e-7 Parkinson's disease; CESC trans rs7746199 0.673 rs35501037 chr6:27739566 T/A cg01620082 chr3:125678407 NA -0.75 -6.08 -0.35 4.29e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs2425143 0.908 rs6060625 chr20:34414318 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 5.49 0.32 9.59e-8 Blood protein levels; CESC cis rs9457247 1.000 rs400837 chr6:167411008 T/C cg25258033 chr6:167368657 RNASET2 0.4 6.14 0.35 2.93e-9 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14212983 chr1:21985742 RAP1GAP 0.57 6.85 0.39 5.24e-11 Gut microbiome composition (summer); CESC cis rs11645898 0.745 rs72787062 chr16:72105844 G/A cg14768367 chr16:72042858 DHODH -0.74 -6.32 -0.36 1.09e-9 Blood protein levels; CESC cis rs8180040 0.966 rs4858868 chr3:47455086 G/A cg27129171 chr3:47204927 SETD2 0.63 9.61 0.51 6.12e-19 Colorectal cancer; CESC cis rs17376456 0.877 rs28637444 chr5:93495548 C/T cg25358565 chr5:93447407 FAM172A 1.17 10.96 0.56 2.63e-23 Diabetic retinopathy; CESC cis rs9309473 0.519 rs6746971 chr2:73669462 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -7.21 -0.41 5.7e-12 Metabolite levels; CESC cis rs4727027 0.933 rs917122 chr7:148848257 T/C cg23158103 chr7:148848205 ZNF398 -0.43 -7.08 -0.4 1.27e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs11098499 0.863 rs59732491 chr4:120489588 G/C cg24375607 chr4:120327624 NA 0.48 5.95 0.34 8.26e-9 Corneal astigmatism; CESC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg08470875 chr2:26401718 FAM59B 0.59 6.16 0.35 2.71e-9 Gut microbiome composition (summer); CESC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.66 7.12 0.4 1.04e-11 Alzheimer's disease; CESC cis rs561341 1.000 rs535151 chr17:30317405 C/T cg19193384 chr17:30244184 NA -0.52 -6.16 -0.35 2.67e-9 Hip circumference adjusted for BMI; CESC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg26314531 chr2:26401878 FAM59B -0.66 -7.14 -0.4 8.76e-12 Gut microbiome composition (summer); CESC cis rs4803468 0.763 rs17318596 chr19:41937095 A/G cg09537434 chr19:41945824 ATP5SL -1.1 -20.07 -0.78 4.09e-55 Height; CESC cis rs929354 0.772 rs1182362 chr7:157019535 A/G cg05182265 chr7:156933206 UBE3C 0.52 7.57 0.42 6.18e-13 Body mass index; CESC cis rs1577917 1.000 rs12209127 chr6:86724427 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.17 -0.35 2.58e-9 Response to antipsychotic treatment; CESC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg17724175 chr1:150552817 MCL1 0.4 6.09 0.35 3.97e-9 Melanoma; CESC cis rs10465746 0.746 rs6663949 chr1:84452853 T/C cg10977910 chr1:84465055 TTLL7 0.51 6.99 0.39 2.27e-11 Obesity-related traits; CESC cis rs9858542 0.953 rs9837341 chr3:49664767 A/G cg03060546 chr3:49711283 APEH -0.57 -6.71 -0.38 1.21e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7474896 0.559 rs10740949 chr10:37978435 A/G cg25427524 chr10:38739819 LOC399744 -0.46 -5.37 -0.31 1.76e-7 Obesity (extreme); CESC cis rs9837602 1.000 rs13064704 chr3:99767541 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 7.51 0.42 8.91e-13 Breast cancer; CESC cis rs7617773 0.780 rs6442111 chr3:48312060 G/C cg11946769 chr3:48343235 NME6 0.8 10.74 0.55 1.38e-22 Coronary artery disease; CESC cis rs1707322 0.752 rs28438704 chr1:46170544 G/A cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6088580 0.524 rs6088560 chr20:33228549 T/C cg07148914 chr20:33460835 GGT7 -0.4 -5.06 -0.3 7.78e-7 Glomerular filtration rate (creatinine); CESC cis rs854765 0.547 rs2955384 chr17:17939573 C/T cg04398451 chr17:18023971 MYO15A -0.7 -10.46 -0.54 1.16e-21 Total body bone mineral density; CESC cis rs11229555 1.000 rs3168135 chr11:58386177 G/A cg15696309 chr11:58395628 NA -0.43 -5.64 -0.33 4.3e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.15 0.3 5.06e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4975709 0.758 rs4975756 chr5:1882443 T/C cg12288994 chr5:1860383 NA 0.37 5.76 0.33 2.29e-8 Cardiovascular disease risk factors; CESC cis rs9815354 0.812 rs73069390 chr3:41785513 C/T cg03022575 chr3:42003672 ULK4 0.73 6.35 0.36 9.44e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs962856 0.964 rs1552359 chr2:67615429 A/G cg09028215 chr2:67624308 ETAA1 -0.4 -5.34 -0.31 2.01e-7 Pancreatic cancer; CESC cis rs2952156 1.000 rs2952156 chr17:37876835 A/G cg07936489 chr17:37558343 FBXL20 -0.52 -6.05 -0.35 4.96e-9 Asthma; CESC cis rs2070488 0.931 rs6599212 chr3:38558906 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.91 -16.62 -0.71 5.46e-43 Electrocardiographic conduction measures; CESC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg07677032 chr17:61819896 STRADA 0.45 5.94 0.34 8.83e-9 Prudent dietary pattern; CESC cis rs2276314 0.512 rs7227264 chr18:33454631 A/C cg05985134 chr18:33552581 C18orf21 0.42 5.04 0.3 8.71e-7 Endometriosis;Drug-induced torsades de pointes; CESC cis rs13082711 0.554 rs34066402 chr3:27387987 G/A cg02860705 chr3:27208620 NA 0.74 8.35 0.46 3.74e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs6964587 1.000 rs6969981 chr7:91689461 G/C cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.45e-15 Breast cancer; CESC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg18876405 chr7:65276391 NA 0.52 7.03 0.4 1.8e-11 Aortic root size; CESC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg05863683 chr7:1912471 MAD1L1 0.39 5.58 0.32 5.85e-8 Schizophrenia; CESC trans rs7618501 0.699 rs9821675 chr3:49902544 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.49 6.7 0.38 1.25e-10 Intelligence (multi-trait analysis); CESC cis rs546131 0.928 rs553789 chr11:34827579 G/A cg11058730 chr11:34937778 PDHX;APIP 0.49 6.31 0.36 1.14e-9 Lung disease severity in cystic fibrosis; CESC cis rs17826219 0.568 rs9898097 chr17:29072672 T/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Body mass index; CESC cis rs1577917 0.958 rs12208227 chr6:86670944 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.19 -0.36 2.31e-9 Response to antipsychotic treatment; CESC cis rs10791097 0.720 rs6590516 chr11:130733393 G/T cg12179176 chr11:130786555 SNX19 0.62 9.25 0.49 7.75e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg00074818 chr8:8560427 CLDN23 0.37 5.45 0.32 1.16e-7 Obesity-related traits; CESC cis rs11676348 0.846 rs13009946 chr2:219007752 A/C cg20019365 chr2:219134978 PNKD;AAMP -0.39 -5.13 -0.3 5.64e-7 Ulcerative colitis; CESC cis rs6964587 1.000 rs6465347 chr7:91693837 A/G cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.45e-15 Breast cancer; CESC cis rs1499972 0.590 rs62264780 chr3:117654869 T/C cg07612923 chr3:117604196 NA 0.69 6.3 0.36 1.22e-9 Schizophrenia; CESC cis rs708547 0.624 rs1718886 chr4:57849251 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.57 8.45 0.46 1.95e-15 Response to bleomycin (chromatid breaks); CESC cis rs6466055 0.501 rs7776707 chr7:104605530 C/A cg04380332 chr7:105027541 SRPK2 -0.38 -5.48 -0.32 9.76e-8 Schizophrenia; CESC cis rs7772486 0.790 rs3924499 chr6:146232978 A/T cg05347473 chr6:146136440 FBXO30 -0.57 -7.16 -0.4 8.07e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs12971120 0.891 rs3764510 chr18:72166846 A/G cg25817165 chr18:72167213 CNDP2 -0.61 -7.15 -0.4 8.4e-12 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16349006 chr20:48807369 CEBPB 0.6 6.99 0.39 2.26e-11 Gut microbiome composition (summer); CESC cis rs11997175 0.546 rs13282996 chr8:33596397 C/T ch.8.33884649F chr8:33765107 NA 0.56 7.23 0.41 5.07e-12 Body mass index; CESC cis rs9322193 0.607 rs6557165 chr6:150228019 C/G cg01145232 chr6:150245071 RAET1G -0.47 -6.14 -0.35 3.01e-9 Lung cancer; CESC cis rs863345 0.604 rs11264981 chr1:158455890 C/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.14 -0.4 8.77e-12 Pneumococcal bacteremia; CESC cis rs6963495 0.818 rs6961233 chr7:105150469 C/T cg13798780 chr7:105162888 PUS7 0.76 7.8 0.43 1.47e-13 Bipolar disorder (body mass index interaction); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg07596148 chr16:88772396 CTU2;RNF166 0.44 6.0 0.35 6.38e-9 Thyroid stimulating hormone; CESC trans rs4699982 0.531 rs4700434 chr5:61035802 A/G cg17766468 chr2:74709216 TTC31;CCDC142 -0.52 -6.1 -0.35 3.81e-9 IgG glycosylation; CESC cis rs3768617 0.811 rs12738377 chr1:183031256 C/T ch.1.3577855R chr1:183094577 LAMC1 0.66 9.02 0.48 3.97e-17 Fuchs's corneal dystrophy; CESC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg08888203 chr3:10149979 C3orf24 0.46 6.0 0.35 6.31e-9 Alzheimer's disease; CESC trans rs2727020 0.573 rs7925419 chr11:49231859 C/T cg03929089 chr4:120376271 NA -0.61 -7.67 -0.43 3.36e-13 Coronary artery disease; CESC cis rs7605827 0.930 rs12692266 chr2:15572380 T/C cg19274914 chr2:15703543 NA 0.31 5.44 0.32 1.24e-7 Educational attainment (years of education); CESC cis rs13392177 0.684 rs11682371 chr2:219079513 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.52 -6.45 -0.37 5.27e-10 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs2996428 0.709 rs6424052 chr1:3713746 A/G cg22529645 chr1:3704559 LRRC47 0.42 5.37 0.31 1.74e-7 Red cell distribution width; CESC cis rs3106136 0.967 rs3113862 chr4:95143122 A/G cg11021082 chr4:95130006 SMARCAD1 -0.48 -7.41 -0.41 1.65e-12 Capecitabine sensitivity; CESC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg11644478 chr21:40555479 PSMG1 0.96 13.77 0.65 6.85e-33 Cognitive function; CESC cis rs7713065 0.765 rs2158101 chr5:131769273 G/A cg10809880 chr5:131517096 NA -0.47 -5.24 -0.31 3.36e-7 Lung function (FEV1/FVC); CESC cis rs78456975 0.943 rs13421238 chr2:1576879 G/A cg26248373 chr2:1572462 NA -0.54 -5.25 -0.31 3.14e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7605827 0.866 rs13417550 chr2:15533895 A/G cg19274914 chr2:15703543 NA 0.35 6.35 0.36 9.17e-10 Educational attainment (years of education); CESC cis rs10754283 0.967 rs10922685 chr1:90118320 A/G cg21401794 chr1:90099060 LRRC8C 0.69 9.16 0.49 1.49e-17 Amyotrophic lateral sclerosis (sporadic); CESC cis rs10197940 0.624 rs10497081 chr2:152353395 T/G cg06191203 chr2:152266755 RIF1 -0.45 -5.2 -0.3 4e-7 Lung cancer; CESC cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg26475306 chr20:33999876 UQCC 0.51 6.36 0.36 8.56e-10 Psoriatic arthritis; CESC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg08888203 chr3:10149979 C3orf24 0.53 6.83 0.39 5.8200000000000003e-11 Alzheimer's disease; CESC cis rs662064 0.928 rs685746 chr1:10537437 C/G cg07384165 chr1:10488281 NA -0.44 -5.67 -0.33 3.75e-8 Asthma; CESC cis rs7267979 1.000 rs6076336 chr20:25319212 C/T cg08601574 chr20:25228251 PYGB -0.39 -5.61 -0.33 4.99e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1322639 0.614 rs9364361 chr6:169580499 C/T cg03254818 chr6:169586852 NA 0.55 5.95 0.34 8.36e-9 Pulse pressure; CESC cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg24920358 chr1:40204285 PPIE -0.41 -6.15 -0.35 2.84e-9 Blood protein levels; CESC cis rs4906332 1.000 rs13987 chr14:103969909 A/G cg09975044 chr14:104007538 NA 0.47 6.16 0.35 2.65e-9 Coronary artery disease; CESC cis rs539096 0.500 rs803678 chr1:44350898 G/T cg13606994 chr1:44402422 ARTN -0.39 -6.09 -0.35 3.94e-9 Intelligence (multi-trait analysis); CESC cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.56 0.37 2.8e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1008375 0.966 rs3733581 chr4:17695206 C/G cg16339924 chr4:17578868 LAP3 -0.62 -7.38 -0.41 2.03e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9309473 0.950 rs10189885 chr2:73877055 A/G cg20560298 chr2:73613845 ALMS1 -0.54 -6.87 -0.39 4.68e-11 Metabolite levels; CESC cis rs2228479 0.702 rs12599561 chr16:89894358 C/G cg06558623 chr16:89946397 TCF25 1.12 8.24 0.45 7.86e-15 Skin colour saturation; CESC cis rs1371867 0.513 rs1542812 chr8:101207064 G/A cg11906718 chr8:101322791 RNF19A -0.44 -5.68 -0.33 3.58e-8 Atrioventricular conduction; CESC cis rs9443189 0.865 rs2133190 chr6:76443493 A/G cg01950844 chr6:76311363 SENP6 -0.56 -6.15 -0.35 2.84e-9 Prostate cancer; CESC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg08470875 chr2:26401718 FAM59B -0.47 -5.22 -0.31 3.63e-7 Gut microbiome composition (summer); CESC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg19468946 chr17:37922297 IKZF3 0.39 5.09 0.3 6.85e-7 Glomerular filtration rate (creatinine); CESC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg12463550 chr7:65579703 CRCP -0.46 -5.81 -0.34 1.76e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21306218 chr16:89787478 ZNF276;C16orf7 0.56 7.03 0.4 1.75e-11 Gut microbiome composition (summer); CESC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg25036284 chr2:26402008 FAM59B -0.59 -6.9 -0.39 3.85e-11 Gut microbiome composition (summer); CESC cis rs9457247 0.765 rs9457249 chr6:167426438 A/G cg23791538 chr6:167370224 RNASET2 -0.53 -7.29 -0.41 3.51e-12 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13187433 chr1:9416179 SPSB1 -0.61 -7.0 -0.4 2.11e-11 Gut microbiome composition (summer); CESC cis rs6815814 0.678 rs9715841 chr4:38774503 T/C cg02016764 chr4:38805732 TLR1 -0.44 -6.08 -0.35 4.24e-9 Breast cancer; CESC cis rs12912251 1.000 rs12912251 chr15:38986368 G/T cg01338139 chr15:38987640 C15orf53 -0.48 -5.51 -0.32 8.36e-8 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs61008539 0.586 rs6959154 chr7:856320 C/T cg15782153 chr7:917662 C7orf20 0.5 7.17 0.4 7.53e-12 Perceived unattractiveness to mosquitoes; CESC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg19717773 chr7:2847554 GNA12 -0.45 -6.39 -0.37 7.45e-10 Height; CESC cis rs796364 0.760 rs2202922 chr2:200882610 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 7.76 0.43 1.81e-13 Schizophrenia; CESC cis rs4919087 0.962 rs10748694 chr10:99056190 A/T cg25902810 chr10:99078978 FRAT1 0.71 10.43 0.54 1.5e-21 Monocyte count; CESC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg10691866 chr7:65817282 TPST1 0.34 5.59 0.32 5.54e-8 Aortic root size; CESC cis rs8058578 0.832 rs7500719 chr16:30840877 C/T cg00531865 chr16:30841666 NA -0.43 -5.53 -0.32 7.71e-8 Multiple myeloma; CESC cis rs798766 0.909 rs28521716 chr4:1745751 A/G cg05874882 chr4:1763078 NA -0.56 -7.25 -0.41 4.65e-12 Bladder cancer;Urinary bladder cancer; CESC cis rs3820928 0.934 rs66959645 chr2:227761582 C/A cg11843606 chr2:227700838 RHBDD1 -0.44 -5.84 -0.34 1.54e-8 Pulmonary function; CESC cis rs6968419 0.755 rs3823977 chr7:115893407 A/T cg02561103 chr7:115862891 TES -0.4 -5.13 -0.3 5.62e-7 Intraocular pressure; CESC cis rs2228479 0.850 rs11640336 chr16:89941153 T/C cg04013166 chr16:89971882 TCF25 0.77 7.03 0.4 1.73e-11 Skin colour saturation; CESC cis rs861020 0.883 rs680331 chr1:209959872 G/A cg05527609 chr1:210001259 C1orf107 1.02 13.35 0.63 1.89e-31 Orofacial clefts; CESC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg24829409 chr8:58192753 C8orf71 -0.64 -7.17 -0.4 7.42e-12 Developmental language disorder (linguistic errors); CESC cis rs1348850 0.872 rs4893824 chr2:178298104 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.8 10.45 0.54 1.24e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7503807 1.000 rs8079537 chr17:78600818 A/G cg09596252 chr17:78655493 RPTOR 0.5 7.24 0.41 4.84e-12 Obesity; CESC cis rs1448094 0.617 rs2221319 chr12:86468064 C/A cg02569458 chr12:86230093 RASSF9 -0.38 -5.52 -0.32 8.26e-8 Major depressive disorder; CESC cis rs11741688 0.597 rs6880072 chr5:178334480 G/C cg20935368 chr5:178288625 ZNF354B 0.34 5.37 0.31 1.71e-7 Sleep duration; CESC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg12034118 chr1:209979487 IRF6 0.42 5.29 0.31 2.55e-7 Cleft lip with or without cleft palate; CESC cis rs6426558 0.537 rs4351610 chr1:227325245 A/G cg10327440 chr1:227177885 CDC42BPA -0.47 -5.9 -0.34 1.13e-8 Neutrophil percentage of white cells; CESC cis rs11711311 1.000 rs12695295 chr3:113474866 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.58 7.86 0.43 9.5e-14 IgG glycosylation; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22394521 chr20:61569754 DIDO1;C20orf11 0.45 6.22 0.36 1.9e-9 Intelligence (multi-trait analysis); CESC cis rs9300255 0.770 rs7980687 chr12:123822711 G/A cg00376283 chr12:123451042 ABCB9 -0.61 -6.6 -0.38 2.23e-10 Neutrophil percentage of white cells; CESC cis rs4563143 0.675 rs55849754 chr19:29279665 G/A cg14983838 chr19:29218262 NA 0.48 5.62 0.33 4.73e-8 Methadone dose in opioid dependence; CESC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg11764359 chr7:65958608 NA -0.78 -11.6 -0.58 1.91e-25 Aortic root size; CESC cis rs2625529 0.689 rs4526973 chr15:72138719 A/G cg16672083 chr15:72433130 SENP8 -0.42 -6.23 -0.36 1.82e-9 Red blood cell count; CESC cis rs7772486 0.754 rs9386134 chr6:146145508 G/A cg05347473 chr6:146136440 FBXO30 0.55 6.8 0.39 6.94e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7809950 1.000 rs2520271 chr7:107194949 C/T cg23024343 chr7:107201750 COG5 -0.42 -5.89 -0.34 1.14e-8 Coronary artery disease; CESC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9549260 0.755 rs2721044 chr13:41162225 C/T cg21288729 chr13:41239152 FOXO1 0.63 7.87 0.44 9.15e-14 Red blood cell count; CESC cis rs2180341 0.924 rs6930849 chr6:127630963 A/T cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6e-39 Breast cancer; CESC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg25405998 chr7:65216604 CCT6P1 0.52 5.79 0.34 1.99e-8 Aortic root size; CESC cis rs13382862 0.823 rs12710743 chr2:20880714 T/C cg07755735 chr2:20870362 GDF7 -0.46 -6.87 -0.39 4.7e-11 Abdominal aortic aneurysm; CESC cis rs7927771 1.000 rs35902101 chr11:47795169 C/T cg05585544 chr11:47624801 NA -0.5 -7.86 -0.43 9.61e-14 Subjective well-being; CESC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg25985355 chr7:65971099 NA -0.44 -5.7 -0.33 3.14e-8 Diabetic kidney disease; CESC cis rs72781680 0.611 rs55868657 chr2:24295385 G/A cg20701182 chr2:24300061 SF3B14 0.93 10.58 0.54 4.83e-22 Lymphocyte counts; CESC cis rs11098499 0.820 rs12503082 chr4:120284317 A/G cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs6688613 0.694 rs3820387 chr1:166820284 A/T ch.1.3259774R chr1:166827647 TADA1 0.55 5.49 0.32 9.6e-8 Refractive astigmatism; CESC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg23161317 chr6:28129485 ZNF389 0.51 6.38 0.36 7.9e-10 Parkinson's disease; CESC cis rs11030122 0.702 rs66503725 chr11:3980998 G/A cg18678763 chr11:4115507 RRM1 -0.49 -6.59 -0.38 2.4e-10 Mean platelet volume;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13077517 chr20:2082435 STK35 0.58 7.22 0.41 5.56e-12 Gut microbiome composition (summer); CESC cis rs28374715 0.681 rs8037574 chr15:41630770 T/C cg02330683 chr15:41787940 ITPKA 0.47 6.28 0.36 1.35e-9 Ulcerative colitis; CESC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.9 0.39 3.85e-11 Bipolar disorder; CESC cis rs6460942 0.591 rs62448726 chr7:12330881 A/G cg02935154 chr7:12443704 VWDE -0.53 -5.5 -0.32 9.01e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03729288 chr17:7232752 NEURL4 0.63 7.25 0.41 4.65e-12 Gut microbiome composition (summer); CESC cis rs4481887 0.927 rs4453081 chr1:248475691 C/G cg00666640 chr1:248458726 OR2T12 0.33 5.3 0.31 2.45e-7 Common traits (Other); CESC cis rs4319547 0.695 rs6488939 chr12:122858250 T/C cg05707623 chr12:122985044 ZCCHC8 -0.45 -5.29 -0.31 2.62e-7 Body mass index; CESC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg11764359 chr7:65958608 NA 0.95 15.41 0.69 1.05e-38 Aortic root size; CESC cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.53 5.26 0.31 2.97e-7 Cerebrospinal P-tau181p levels; CESC cis rs10242455 0.702 rs57832867 chr7:98966396 C/T cg25640893 chr7:99214727 ZNF498 0.85 5.47 0.32 1.02e-7 Blood metabolite levels; CESC cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.754 rs10518300 chr4:120249499 G/T cg09307838 chr4:120376055 NA -0.65 -8.17 -0.45 1.26e-14 Corneal astigmatism; CESC cis rs10207060 1.000 rs10207060 chr2:240687289 A/C cg07506560 chr2:240697449 NA 0.36 5.2 0.3 3.89e-7 Obesity-related traits; CESC cis rs10504073 0.647 rs12156111 chr8:50017328 G/C cg00325661 chr8:49890786 NA 0.53 8.1 0.45 1.98e-14 Blood metabolite ratios; CESC cis rs6089584 0.528 rs4925334 chr20:60626769 C/T cg24733560 chr20:60626293 TAF4 0.48 7.12 0.4 1e-11 Body mass index; CESC cis rs708547 0.581 rs10020462 chr4:57825593 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.53 -6.87 -0.39 4.55e-11 Response to bleomycin (chromatid breaks); CESC cis rs9660992 0.649 rs12128229 chr1:205268014 C/A cg00857998 chr1:205179979 DSTYK 0.48 5.33 0.31 2.15e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg04455712 chr21:45112962 RRP1B 0.46 7.4 0.41 1.77e-12 Mean corpuscular volume; CESC cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg11279151 chr3:101281821 RG9MTD1 -0.46 -5.17 -0.3 4.72e-7 Colonoscopy-negative controls vs population controls; CESC trans rs1973993 0.662 rs2057427 chr1:96888897 C/G cg10631902 chr5:14652156 NA -0.5 -6.49 -0.37 4.21e-10 Weight; CESC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg18305652 chr10:134549665 INPP5A 0.49 6.96 0.39 2.7e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4409675 0.576 rs2295367 chr1:28224312 C/T cg23691781 chr1:28212827 C1orf38 0.28 5.68 0.33 3.53e-8 Corneal astigmatism; CESC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg21963583 chr11:68658836 MRPL21 0.38 5.59 0.32 5.63e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11997175 0.646 rs7464237 chr8:33716596 C/T ch.8.33884649F chr8:33765107 NA 0.55 7.36 0.41 2.26e-12 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03665832 chr7:98923565 ARPC1A 0.54 6.5 0.37 4.08e-10 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg11663144 chr21:46675770 NA -0.62 -9.74 -0.51 2.36e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs35079168 0.923 rs10858276 chr9:137287913 C/T cg00753924 chr9:137298813 RXRA -0.35 -5.52 -0.32 7.88e-8 Intelligence; CESC cis rs6676180 0.555 rs12060730 chr1:119770702 A/G cg05756136 chr1:119680316 WARS2 -0.4 -5.26 -0.31 3.03e-7 Monobrow; CESC cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg05347473 chr6:146136440 FBXO30 -0.55 -6.97 -0.39 2.54e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg13770153 chr20:60521292 NA -0.44 -5.71 -0.33 3.02e-8 Body mass index; CESC cis rs2046867 0.818 rs62249875 chr3:72911858 G/A cg25664220 chr3:72788482 NA -0.45 -6.65 -0.38 1.64e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs793571 0.503 rs1427281 chr15:58959273 T/C cg05156742 chr15:59063176 FAM63B 0.51 6.3 0.36 1.21e-9 Schizophrenia; CESC cis rs28830936 1.000 rs2412622 chr15:41960311 A/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.37 -5.29 -0.31 2.63e-7 Diastolic blood pressure; CESC cis rs7555523 0.887 rs12691499 chr1:165687665 A/C cg24409356 chr1:165738333 TMCO1 0.73 6.67 0.38 1.5e-10 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs2204008 0.806 rs11525001 chr12:38234397 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.57 0.32 6.11e-8 Bladder cancer; CESC cis rs7202877 0.706 rs247434 chr16:75445304 G/A cg04384234 chr16:75411784 CFDP1 0.48 5.57 0.32 6.29e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.715 rs8129601 chr21:45119104 A/G cg21573476 chr21:45109991 RRP1B -0.51 -7.31 -0.41 3.19e-12 Mean corpuscular volume; CESC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg25427524 chr10:38739819 LOC399744 -0.67 -9.8 -0.52 1.46e-19 Extrinsic epigenetic age acceleration; CESC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg07677032 chr17:61819896 STRADA 0.44 5.58 0.32 6.08e-8 Height; CESC cis rs977987 0.778 rs4888409 chr16:75436231 A/T cg03315344 chr16:75512273 CHST6 0.41 5.85 0.34 1.43e-8 Dupuytren's disease; CESC cis rs17539620 0.534 rs6557363 chr6:154827813 A/G cg20019720 chr6:154832845 CNKSR3 0.41 5.85 0.34 1.43e-8 Lipoprotein (a) levels; CESC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs28489187 0.706 rs173026 chr1:85804249 G/A cg16011679 chr1:85725395 C1orf52 0.48 5.6 0.33 5.29e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs629535 0.734 rs659430 chr8:70009988 A/G cg21567404 chr3:27674614 NA 0.58 7.32 0.41 2.95e-12 Dupuytren's disease; CESC cis rs72781680 0.651 rs13019016 chr2:23894773 C/G cg20701182 chr2:24300061 SF3B14 0.56 5.07 0.3 7.45e-7 Lymphocyte counts; CESC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg11764359 chr7:65958608 NA -0.8 -9.04 -0.49 3.45e-17 Aortic root size; CESC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg17949981 chr6:28129498 ZNF389 0.44 5.58 0.32 5.97e-8 Depression; CESC cis rs9929218 0.954 rs35794312 chr16:68827785 G/A cg02972257 chr16:68554789 NA 0.46 5.45 0.32 1.12e-7 Colorectal cancer; CESC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg00149659 chr3:10157352 C3orf10 0.7 8.47 0.46 1.68e-15 Alzheimer's disease; CESC cis rs2777491 0.574 rs1757468 chr15:41743574 T/A cg02330683 chr15:41787940 ITPKA 0.42 5.09 0.3 6.8e-7 Ulcerative colitis; CESC cis rs793571 0.500 rs2555356 chr15:59016431 T/G cg05156742 chr15:59063176 FAM63B 0.58 7.72 0.43 2.43e-13 Schizophrenia; CESC cis rs12497850 1.000 rs1352420 chr3:48757291 A/G cg07636037 chr3:49044803 WDR6 0.97 16.72 0.72 2.42e-43 Parkinson's disease; CESC cis rs4481887 0.927 rs10158431 chr1:248481253 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.56 0.37 2.84e-10 Common traits (Other); CESC cis rs2109514 0.840 rs6953982 chr7:116129290 C/T cg12739419 chr7:116140593 CAV2 -0.38 -6.76 -0.38 8.91e-11 Prevalent atrial fibrillation; CESC cis rs929354 0.772 rs6954050 chr7:156978554 A/G cg05182265 chr7:156933206 UBE3C -0.51 -7.5 -0.42 9.58e-13 Body mass index; CESC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.07e-8 Lung cancer; CESC cis rs9815354 1.000 rs9830064 chr3:41881801 T/C cg03022575 chr3:42003672 ULK4 0.45 5.26 0.31 2.97e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs61996546 0.635 rs61998671 chr15:26853000 T/C cg15066197 chr15:26874202 GABRB3 -0.35 -5.19 -0.3 4.1e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03161587 chr2:220405163 CHPF -0.61 -6.93 -0.39 3.18e-11 Gut microbiome composition (summer); CESC cis rs9522267 0.535 rs9515454 chr13:112236885 A/G cg10483660 chr13:112241077 NA -0.33 -5.78 -0.33 2.14e-8 Hepatitis; CESC cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg12386194 chr3:101231763 SENP7 0.43 5.54 0.32 7.32e-8 Colorectal cancer; CESC cis rs2286503 1.000 rs1029740 chr7:22873586 C/A cg13679077 chr7:22862647 TOMM7 0.43 5.46 0.32 1.12e-7 Fibrinogen; CESC cis rs734999 0.545 rs12752515 chr1:2564465 T/C cg20673091 chr1:2541236 MMEL1 -0.47 -7.84 -0.43 1.11e-13 Ulcerative colitis; CESC cis rs10392 0.543 rs4810245 chr20:37549309 G/A cg27552599 chr20:37590471 DHX35 0.38 5.47 0.32 1.05e-7 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs796364 0.806 rs55985986 chr2:201120987 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -6.5 -0.37 3.91e-10 Schizophrenia; CESC cis rs9303401 0.659 rs17222523 chr17:56620501 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.54e-29 Cognitive test performance; CESC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg13206674 chr6:150067644 NUP43 0.45 6.48 0.37 4.53e-10 Lung cancer; CESC cis rs4594175 0.926 rs10149006 chr14:51615265 A/C cg23942311 chr14:51606299 NA 0.36 5.37 0.31 1.76e-7 Cancer; CESC cis rs7116495 0.609 rs628025 chr11:71802351 A/C cg18441811 chr11:71824068 C11orf51 -0.84 -5.32 -0.31 2.22e-7 Severe influenza A (H1N1) infection; CESC trans rs4803480 0.766 rs115449590 chr19:42088883 T/C cg14584244 chr5:176003139 PCDH24 -0.47 -6.17 -0.35 2.49e-9 Schizophrenia; CESC cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg11644478 chr21:40555479 PSMG1 1.01 15.65 0.69 1.48e-39 Cognitive function; CESC cis rs473651 0.904 rs472247 chr2:239362573 G/A cg18131467 chr2:239335373 ASB1 0.99 18.97 0.76 2.74e-51 Multiple system atrophy; CESC cis rs8072100 1.000 rs4375701 chr17:45712218 C/T cg08085267 chr17:45401833 C17orf57 -0.43 -5.66 -0.33 3.85e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.86 9.01 0.48 4.24e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7662987 1.000 rs11547772 chr4:99992793 A/C cg13256891 chr4:100009986 ADH5 -0.82 -6.15 -0.35 2.89e-9 Smoking initiation; CESC cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg20503657 chr10:835505 NA 1.09 9.95 0.52 4.95e-20 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg03467027 chr4:99064603 C4orf37 0.44 5.56 0.32 6.57e-8 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15072735 chr9:72375102 PTAR1 -0.42 -6.01 -0.35 5.99e-9 Gambling; CESC cis rs2304069 0.565 rs13183261 chr5:149421847 T/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.48 6.5 0.37 3.98e-10 HIV-1 control; CESC cis rs9583531 0.600 rs9555724 chr13:111354110 C/T cg24331049 chr13:111365604 ING1 -0.67 -10.23 -0.53 6.24e-21 Coronary artery disease; CESC cis rs1976403 0.659 rs10799699 chr1:21820961 C/T cg04349561 chr1:21808255 NBPF3 -0.4 -5.81 -0.34 1.77e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9527 0.590 rs10883843 chr10:104947493 C/G cg04362960 chr10:104952993 NT5C2 0.43 5.43 0.32 1.3e-7 Arsenic metabolism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21609034 chr20:3869759 PANK2 0.58 6.75 0.38 9.17e-11 Gut microbiome composition (summer); CESC cis rs7212590 0.748 rs58681483 chr17:57934654 A/G cg20303301 chr17:57937339 TUBD1 -0.58 -5.71 -0.33 3.05e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg01988459 chr11:68622903 NA -0.39 -5.21 -0.3 3.76e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2302729 0.578 rs11062298 chr12:2771709 A/C cg19945202 chr12:2788847 CACNA1C -0.47 -7.01 -0.4 2e-11 Sleep quality; CESC cis rs7259376 0.936 rs7256749 chr19:22592289 A/G cg02657401 chr19:22469223 NA 0.26 5.14 0.3 5.46e-7 Menopause (age at onset); CESC cis rs7940866 0.838 rs10736592 chr11:130800572 C/T cg12179176 chr11:130786555 SNX19 0.66 10.05 0.53 2.38e-20 Schizophrenia; CESC cis rs10744422 0.920 rs897393 chr12:123312051 A/G cg25930673 chr12:123319894 HIP1R 0.65 5.3 0.31 2.42e-7 Schizophrenia; CESC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg13206674 chr6:150067644 NUP43 0.43 5.98 0.34 7.33e-9 Lung cancer; CESC cis rs7089973 0.628 rs11196953 chr10:116607707 A/G cg23260525 chr10:116636907 FAM160B1 0.4 7.2 0.4 6.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg19857114 chr3:176741225 TBL1XR1 0.46 6.41 0.37 6.68e-10 Positive affect; CESC cis rs243505 0.559 rs10215159 chr7:148479071 G/C cg09806900 chr7:148480153 CUL1 0.44 5.31 0.31 2.35e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs916888 0.779 rs199528 chr17:44843136 C/T cg15921436 chr17:44337874 NA 0.74 7.89 0.44 8.12e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.75 9.82 0.52 1.34e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs6502050 0.871 rs6502054 chr17:80066715 G/A cg23985595 chr17:80112537 CCDC57 0.41 6.34 0.36 9.73e-10 Life satisfaction; CESC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.13 -0.35 3.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6460942 0.730 rs73053536 chr7:12323131 C/G cg10578991 chr7:12443926 VWDE -0.62 -6.19 -0.36 2.29e-9 Coronary artery disease; CESC cis rs3026101 0.671 rs17636147 chr17:5315299 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.83 0.34 1.6e-8 Body mass index; CESC cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.55 -0.42 6.87e-13 Alzheimer's disease; CESC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.89 -13.73 -0.64 8.78e-33 Prudent dietary pattern; CESC cis rs7918232 0.782 rs7910168 chr10:27465296 G/A cg14240646 chr10:27532245 ACBD5 -0.67 -6.55 -0.37 3.03e-10 Breast cancer; CESC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 7.74 0.43 2.09e-13 Menopause (age at onset); CESC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.84 0.59 2.99e-26 Alzheimer's disease; CESC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg23283495 chr1:209979779 IRF6 -0.5 -7.05 -0.4 1.52e-11 Cleft lip with or without cleft palate; CESC cis rs5769765 0.955 rs1321 chr22:50297435 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.47 -5.55 -0.32 7.08e-8 Schizophrenia; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg01936430 chr1:204380496 PPP1R15B 0.47 6.44 0.37 5.45e-10 Bronchopulmonary dysplasia; CESC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg10691866 chr7:65817282 TPST1 0.32 5.46 0.32 1.08e-7 Aortic root size; CESC cis rs933688 1.000 rs1035476 chr5:90745976 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 13.92 0.65 1.96e-33 Smoking behavior; CESC cis rs7927771 0.864 rs2868459 chr11:47454972 C/G cg18512352 chr11:47633146 NA -0.52 -7.39 -0.41 1.92e-12 Subjective well-being; CESC cis rs425277 1.000 rs421992 chr1:2077260 C/T cg24578937 chr1:2090814 PRKCZ 0.55 9.56 0.51 8.64e-19 Height; CESC cis rs16854884 0.657 rs35193361 chr3:143716420 A/G cg06585982 chr3:143692056 C3orf58 0.45 5.32 0.31 2.23e-7 Economic and political preferences (feminism/equality); CESC cis rs17253792 0.822 rs77420254 chr14:56069646 C/T cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs4973397 0.774 rs12998237 chr2:232276651 T/C cg09339159 chr2:232260559 B3GNT7 0.58 5.86 0.34 1.4e-8 Anti-saccade response; CESC cis rs6547741 0.935 rs6749426 chr2:27847606 T/C cg27432699 chr2:27873401 GPN1 0.49 6.89 0.39 3.95e-11 Oral cavity cancer; CESC cis rs10861342 1.000 rs7136344 chr12:105528268 A/G cg23923672 chr12:105501055 KIAA1033 0.66 5.71 0.33 3.09e-8 IgG glycosylation; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg08514185 chr20:61847713 YTHDF1 -0.42 -5.99 -0.35 6.69e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9583531 0.600 rs2119479 chr13:111371181 A/C cg24331049 chr13:111365604 ING1 0.74 10.91 0.56 4.04e-23 Coronary artery disease; CESC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01252513 chr12:111758092 CUX2 0.46 6.26 0.36 1.53e-9 Fibrinogen levels; CESC cis rs7520050 0.898 rs4660885 chr1:46243756 C/T cg24296786 chr1:45957014 TESK2 0.47 5.88 0.34 1.21e-8 Red blood cell count;Reticulocyte count; CESC cis rs17376456 0.825 rs10038828 chr5:93124056 C/T cg21475434 chr5:93447410 FAM172A 0.83 7.39 0.41 1.91e-12 Diabetic retinopathy; CESC trans rs2727020 0.575 rs10769587 chr11:49549849 C/G cg03929089 chr4:120376271 NA -0.81 -12.24 -0.6 1.37e-27 Coronary artery disease; CESC cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.71 9.02 0.48 4e-17 Multiple sclerosis; CESC cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs2087017 0.744 rs60796731 chr3:113818727 T/A cg11311190 chr3:113822454 NA -0.35 -6.07 -0.35 4.41e-9 Personality dimensions; CESC cis rs10870270 0.913 rs115236491 chr10:133766855 T/G cg26149184 chr10:133730230 NA 0.38 5.17 0.3 4.57e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs870825 0.616 rs57271221 chr4:185627198 C/T cg04058563 chr4:185651563 MLF1IP 0.64 6.48 0.37 4.51e-10 Blood protein levels; CESC cis rs4919087 0.715 rs946981 chr10:98995076 A/G cg25902810 chr10:99078978 FRAT1 -0.48 -5.37 -0.31 1.72e-7 Monocyte count; CESC cis rs9308433 0.529 rs3767842 chr1:214498306 C/T cg06198575 chr1:214491504 SMYD2 0.49 5.98 0.34 7.22e-9 IgG glycosylation; CESC cis rs3749237 0.595 rs4855864 chr3:49521974 C/T cg02487422 chr3:49467188 NICN1 0.59 8.52 0.46 1.2e-15 Resting heart rate; CESC cis rs9858542 1.000 rs6770670 chr3:49686682 T/C cg07274523 chr3:49395745 GPX1 0.67 8.54 0.46 1.03e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4654899 0.865 rs6673455 chr1:21361048 T/C cg05370193 chr1:21551575 ECE1 0.41 6.17 0.35 2.58e-9 Superior frontal gyrus grey matter volume; CESC cis rs7089973 0.604 rs765173 chr10:116601675 C/T cg25233709 chr10:116636983 FAM160B1 0.39 6.49 0.37 4.27e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs62244186 0.516 rs11922470 chr3:44777795 C/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.71 10.48 0.54 9.68e-22 Depressive symptoms; CESC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg11644478 chr21:40555479 PSMG1 1.03 17.63 0.73 1.42e-46 Cognitive function; CESC cis rs75477785 1.000 rs2235371 chr1:209964080 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.81 5.47 0.32 1.04e-7 Cleft lip with or without cleft palate; CESC cis rs7173419 0.607 rs11633338 chr15:28217011 G/A cg20906524 chr15:28200668 OCA2 -0.38 -5.25 -0.31 3.07e-7 Eye color; CESC cis rs116095464 0.558 rs7703803 chr5:292311 A/G cg22857025 chr5:266934 NA -1.28 -17.85 -0.74 2.52e-47 Breast cancer; CESC cis rs11122272 0.735 rs2486737 chr1:231520523 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg12310025 chr6:25882481 NA 0.44 6.56 0.37 2.78e-10 Intelligence (multi-trait analysis); CESC cis rs9840812 0.725 rs696517 chr3:136067655 T/C cg15507776 chr3:136538369 TMEM22 0.51 5.24 0.31 3.29e-7 Fibrinogen levels; CESC cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg17366294 chr4:99064904 C4orf37 0.53 7.06 0.4 1.42e-11 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16218964 chr11:62473680 BSCL2;GNG3 -0.49 -6.22 -0.36 1.96e-9 Ulcerative colitis; CESC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg13880726 chr7:1868755 MAD1L1 0.51 6.9 0.39 3.91e-11 Bipolar disorder and schizophrenia; CESC cis rs11048434 0.736 rs56130437 chr12:9093001 G/A cg04155231 chr12:9217510 LOC144571 0.31 5.04 0.3 8.46e-7 Sjögren's syndrome; CESC cis rs9640161 0.742 rs2108853 chr7:150017589 A/C cg10018233 chr7:150070692 REPIN1 0.45 7.18 0.4 6.86e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs8114671 0.967 rs2093058 chr20:33791281 C/T cg24642439 chr20:33292090 TP53INP2 -0.42 -5.03 -0.3 9.18e-7 Height; CESC cis rs9486715 0.867 rs9384628 chr6:96960232 T/C cg06623918 chr6:96969491 KIAA0776 0.93 14.38 0.66 4.75e-35 Headache; CESC cis rs10129255 0.912 rs8009135 chr14:107185767 A/G cg07958169 chr14:107095056 NA -0.44 -6.07 -0.35 4.32e-9 Kawasaki disease; CESC cis rs3820068 0.603 rs6695903 chr1:15985940 C/T cg17385448 chr1:15911702 AGMAT 0.42 7.18 0.4 7.09e-12 Systolic blood pressure; CESC cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg10556349 chr10:835070 NA 0.58 5.55 0.32 6.87e-8 Eosinophil percentage of granulocytes; CESC cis rs2479724 0.935 rs2254936 chr6:41846569 A/G cg17623882 chr6:41773611 USP49 -0.42 -6.08 -0.35 4.16e-9 Menarche (age at onset); CESC cis rs1568889 0.838 rs10835273 chr11:28156598 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 13.78 0.65 6.22e-33 Bipolar disorder; CESC cis rs2688608 0.618 rs28553894 chr10:75489843 C/A cg23231163 chr10:75533350 FUT11 -0.37 -5.57 -0.32 6.23e-8 Inflammatory bowel disease; CESC cis rs636291 0.517 rs11121579 chr1:10541824 G/C cg20482658 chr1:10539492 PEX14 -0.28 -5.91 -0.34 1.04e-8 Prostate cancer; CESC cis rs7091068 0.518 rs4919436 chr10:95461475 C/T cg20715218 chr10:95462985 C10orf4 0.53 6.61 0.38 2.05e-10 Urinary tract infection frequency; CESC cis rs12325245 0.536 rs35432891 chr16:58561966 G/A cg01152986 chr16:58549298 SETD6 0.89 5.4 0.32 1.45e-7 Schizophrenia; CESC cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg01475377 chr6:109611718 NA -0.49 -8.2 -0.45 1.08e-14 Reticulocyte fraction of red cells; CESC cis rs1707322 1.000 rs10890381 chr1:46451771 T/G cg06784218 chr1:46089804 CCDC17 0.36 6.01 0.35 5.95e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg19500275 chr17:80737654 TBCD 0.48 5.5 0.32 9.14e-8 Glycated hemoglobin levels; CESC cis rs10242455 0.702 rs73713580 chr7:99241610 C/T cg25640893 chr7:99214727 ZNF498 0.78 5.24 0.31 3.31e-7 Blood metabolite levels; CESC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg01988459 chr11:68622903 NA -0.41 -5.3 -0.31 2.42e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg05527609 chr1:210001259 C1orf107 0.47 5.84 0.34 1.53e-8 Monobrow; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10188299 chr14:67982149 TMEM229B -0.5 -6.28 -0.36 1.41e-9 Asthma; CESC cis rs561341 0.941 rs736678 chr17:30347423 G/T cg00745463 chr17:30367425 LRRC37B -0.88 -7.75 -0.43 2.01e-13 Hip circumference adjusted for BMI; CESC cis rs79349575 0.783 rs11079844 chr17:47028334 G/A cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs9788682 0.747 rs6495308 chr15:78907656 A/G cg24631222 chr15:78858424 CHRNA5 0.75 9.41 0.5 2.5e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs4474465 0.850 rs7122676 chr11:78268525 A/G cg27205649 chr11:78285834 NARS2 0.42 5.1 0.3 6.45e-7 Alzheimer's disease (survival time); CESC cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2730245 0.527 rs62476464 chr7:158698063 C/T cg24397884 chr7:158709396 WDR60 0.85 8.85 0.48 1.3e-16 Height; CESC cis rs4906332 1.000 rs17617935 chr14:103952886 A/T cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.49e-10 Coronary artery disease; CESC cis rs7772486 0.837 rs2474354 chr6:146323795 T/A cg23711669 chr6:146136114 FBXO30 0.73 10.36 0.54 2.37e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg04526738 chr4:183727387 NA 0.64 6.38 0.36 7.87e-10 Pediatric autoimmune diseases; CESC cis rs9399135 0.967 rs11755229 chr6:135369913 A/G cg22676075 chr6:135203613 NA 0.5 7.06 0.4 1.43e-11 Red blood cell count; CESC cis rs7618501 1.000 rs1491986 chr3:49739086 C/T cg24308560 chr3:49941425 MST1R 0.5 6.86 0.39 4.8e-11 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.82e-7 Colonoscopy-negative controls vs population controls; CESC cis rs709400 1.000 rs58133129 chr14:104104759 A/G cg12935359 chr14:103987150 CKB -0.45 -6.17 -0.35 2.58e-9 Body mass index; CESC cis rs1215050 0.765 rs471500 chr4:98714820 T/C cg05340658 chr4:99064831 C4orf37 0.51 6.55 0.37 3.04e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7635838 0.892 rs9838141 chr3:11488639 C/T cg00170343 chr3:11313890 ATG7 0.42 5.68 0.33 3.57e-8 HDL cholesterol; CESC cis rs67311347 0.910 rs7651204 chr3:40512835 C/T cg01475735 chr3:40494733 NA 0.41 5.17 0.3 4.71e-7 Renal cell carcinoma; CESC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg13206674 chr6:150067644 NUP43 0.44 6.42 0.37 6.24e-10 Lung cancer; CESC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg12463550 chr7:65579703 CRCP 0.59 7.52 0.42 8.29e-13 Aortic root size; CESC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg13628971 chr7:2884303 GNA12 0.63 8.76 0.47 2.41e-16 Height; CESC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg27170947 chr2:26402098 FAM59B -0.59 -7.07 -0.4 1.36e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24908708 chr8:95835570 INTS8 0.57 6.69 0.38 1.3e-10 Gut microbiome composition (summer); CESC cis rs9581857 0.579 rs79904593 chr13:27996893 G/A cg22138327 chr13:27999177 GTF3A 0.69 5.56 0.32 6.74e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs73206853 0.764 rs59527539 chr12:110968119 A/G cg12870014 chr12:110450643 ANKRD13A 0.65 5.65 0.33 4.14e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg06254406 chr13:103450982 BIVM;KDELC1 -0.47 -7.17 -0.4 7.54e-12 Vertical cup-disc ratio; CESC cis rs9911578 1.000 rs9892795 chr17:57023054 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.12 0.3 5.94e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15622040 chr3:49823987 IP6K1 0.55 6.07 0.35 4.46e-9 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs79262019 chr14:56092704 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.98 0.34 7.23e-9 Putamen volume; CESC trans rs163030 0.875 rs335610 chr5:76747820 A/T cg26150533 chr8:82396069 FABP4 -0.39 -6.0 -0.35 6.54e-9 Caudate nucleus volume; CESC trans rs875971 0.660 rs1860468 chr7:66107252 T/C cg26939375 chr7:64535504 NA -0.56 -7.61 -0.42 4.92e-13 Aortic root size; CESC cis rs7831492 0.564 rs57596574 chr8:41609843 G/A cg17182837 chr8:41585554 ANK1 -0.41 -6.27 -0.36 1.5e-9 Colorectal cancer; CESC cis rs2979489 0.891 rs2915592 chr8:30396417 C/T cg26383811 chr8:30366931 RBPMS -0.79 -9.95 -0.52 5.05e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs2279817 0.735 rs11203432 chr1:17991196 A/G cg21791023 chr1:18019539 ARHGEF10L -0.54 -7.11 -0.4 1.1e-11 Neuroticism; CESC cis rs2898290 0.540 rs35005793 chr8:11450472 G/A cg21775007 chr8:11205619 TDH 0.45 6.42 0.37 6.19e-10 Systolic blood pressure; CESC cis rs7937682 0.883 rs1611989 chr11:111456299 A/G cg22437258 chr11:111473054 SIK2 0.71 9.1 0.49 2.27e-17 Primary sclerosing cholangitis; CESC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg07701084 chr6:150067640 NUP43 0.44 5.94 0.34 8.89e-9 Lung cancer; CESC cis rs250677 0.522 rs6580590 chr5:148360374 C/T cg18129178 chr5:148520854 ABLIM3 0.47 5.16 0.3 4.93e-7 Breast cancer; CESC cis rs17608059 0.518 rs4792436 chr17:13972307 T/A cg11395062 chr17:14139857 CDRT15 -0.54 -6.99 -0.39 2.17e-11 Temperament; CESC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs367943 1.000 rs348963 chr5:112819027 A/G cg12552261 chr5:112820674 MCC -0.6 -7.62 -0.42 4.44e-13 Type 2 diabetes; CESC cis rs854765 0.583 rs8078583 chr17:17811465 C/T cg09796270 chr17:17721594 SREBF1 0.46 6.42 0.37 6.23e-10 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01804284 chr1:41157659 NFYC;LOC100130557 0.6 6.49 0.37 4.22e-10 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11645754 chr17:21188174 MAP2K3 -0.39 -6.02 -0.35 5.66e-9 Gambling; CESC cis rs12801636 0.739 rs12790427 chr11:65384727 C/T cg26668713 chr11:65405903 SIPA1 0.67 7.75 0.43 1.98e-13 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; CESC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg02034447 chr16:89574710 SPG7 0.46 5.91 0.34 1.02e-8 Multiple myeloma (IgH translocation); CESC cis rs4332037 0.707 rs4721096 chr7:1877311 T/C cg23422044 chr7:1970798 MAD1L1 0.57 5.83 0.34 1.6e-8 Bipolar disorder; CESC cis rs748404 0.604 rs2278857 chr15:43632549 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.59 7.54 0.42 7.73e-13 Lung cancer; CESC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg21724239 chr8:58056113 NA 0.58 5.97 0.34 7.54e-9 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.51 0.42 8.95e-13 Prudent dietary pattern; CESC cis rs4595586 0.545 rs2388177 chr12:39364403 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg18479299 chr3:125709523 NA -0.5 -5.75 -0.33 2.5e-8 Blood pressure (smoking interaction); CESC trans rs17685 0.672 rs1639618 chr7:75701987 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.47 0.61 2.13e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs644799 0.965 rs3789960 chr11:95509037 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.64 0.67 5.65e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg07256732 chr16:621771 PIGQ -0.32 -5.64 -0.33 4.27e-8 Height; CESC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg24675658 chr1:53192096 ZYG11B -0.53 -6.59 -0.38 2.36e-10 Monocyte count; CESC trans rs11098499 0.954 rs10034623 chr4:120397829 G/A cg25214090 chr10:38739885 LOC399744 0.71 10.41 0.54 1.73e-21 Corneal astigmatism; CESC cis rs1577917 1.000 rs13194429 chr6:86646705 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.03 -0.35 5.49e-9 Response to antipsychotic treatment; CESC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg01097406 chr16:89675127 NA -0.34 -5.21 -0.31 3.71e-7 Vitiligo; CESC cis rs7429990 0.965 rs5012971 chr3:48074547 C/T cg11946769 chr3:48343235 NME6 -0.44 -5.36 -0.31 1.8e-7 Educational attainment (years of education); CESC cis rs965469 0.779 rs6139048 chr20:3239753 T/G cg25506879 chr20:3388711 C20orf194 -0.51 -5.57 -0.32 6.1e-8 IFN-related cytopenia; CESC cis rs826838 1.000 rs2129627 chr12:38653036 C/T cg26384229 chr12:38710491 ALG10B 0.82 14.26 0.66 1.22e-34 Heart rate; CESC cis rs7824557 0.806 rs10503418 chr8:11118983 C/T cg21775007 chr8:11205619 TDH -0.39 -5.9 -0.34 1.09e-8 Retinal vascular caliber; CESC cis rs2290159 0.948 rs9852128 chr3:12635623 A/G cg23032965 chr3:12705835 RAF1 0.5 5.54 0.32 7.34e-8 Cholesterol, total; CESC trans rs1814175 0.588 rs1794144 chr11:49918233 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs1670533 1.000 rs2290411 chr4:1051077 T/C cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.77e-7 Recombination rate (females); CESC cis rs6547741 0.967 rs4665986 chr2:27755168 G/A cg27432699 chr2:27873401 GPN1 0.49 6.83 0.39 5.72e-11 Oral cavity cancer; CESC cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg18180107 chr4:99064573 C4orf37 0.41 5.24 0.31 3.24e-7 Colonoscopy-negative controls vs population controls; CESC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg11764359 chr7:65958608 NA 0.69 9.18 0.49 1.32e-17 Aortic root size; CESC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg24675658 chr1:53192096 ZYG11B -0.57 -6.92 -0.39 3.47e-11 Monocyte count; CESC cis rs10870270 0.956 rs4131689 chr10:133744328 A/C cg26149184 chr10:133730230 NA -0.4 -5.48 -0.32 9.68e-8 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs10411936 1.000 rs873636 chr19:16514771 C/T cg10248733 chr19:16607483 C19orf44;CALR3 0.45 5.46 0.32 1.12e-7 White blood cell count;Multiple sclerosis; CESC cis rs28673728 0.868 rs28380108 chr1:38409103 G/C cg26398791 chr1:38455867 SF3A3 -0.41 -5.23 -0.31 3.4e-7 Red cell distribution width; CESC cis rs3740713 1.000 rs75381502 chr11:18451886 T/G cg23797887 chr11:18477753 LDHAL6A -0.52 -5.19 -0.3 4.27e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs11577318 0.853 rs12728971 chr1:26626612 C/T cg00852783 chr1:26633632 UBXN11 0.5 6.99 0.39 2.17e-11 Granulocyte percentage of myeloid white cells; CESC cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg26597838 chr10:835615 NA 0.94 9.61 0.51 5.87e-19 Eosinophil percentage of granulocytes; CESC cis rs9291683 0.509 rs998676 chr4:9948564 T/C cg11266682 chr4:10021025 SLC2A9 -0.61 -12.6 -0.61 7.45e-29 Bone mineral density; CESC cis rs10911232 0.507 rs10911212 chr1:183024469 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 13.65 0.64 1.79e-32 Hypertriglyceridemia; CESC cis rs2262909 0.962 rs73019889 chr19:22277826 C/G cg11619707 chr19:22235551 ZNF257 0.35 5.76 0.33 2.38e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs7602441 0.521 rs1434985 chr2:14767916 C/T cg06545361 chr2:14773388 FAM84A 0.69 6.86 0.39 4.91e-11 Visceral adipose tissue adjusted for BMI; CESC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg13607699 chr17:42295918 UBTF 0.59 7.59 0.42 5.44e-13 Total body bone mineral density; CESC cis rs2228479 0.702 rs2074903 chr16:89811663 T/C cg19635926 chr16:89946313 TCF25 0.68 5.17 0.3 4.67e-7 Skin colour saturation; CESC cis rs2011503 1.000 rs11670882 chr19:19649748 C/G cg11584989 chr19:19387371 SF4 0.48 5.81 0.34 1.76e-8 Bipolar disorder; CESC cis rs1348850 0.914 rs12469386 chr2:178358281 A/G cg22681709 chr2:178499509 PDE11A 0.39 5.77 0.33 2.15e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.21e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4889855 0.530 rs9914854 chr17:78598662 A/G cg16591659 chr17:78472290 NA -0.33 -5.25 -0.31 3.08e-7 Fractional excretion of uric acid; CESC cis rs2243480 0.901 rs57126451 chr7:65416306 T/C cg18252515 chr7:66147081 NA -1.07 -10.28 -0.53 4.35e-21 Diabetic kidney disease; CESC cis rs4727027 0.745 rs10952801 chr7:148864757 T/C cg23158103 chr7:148848205 ZNF398 -0.42 -6.88 -0.39 4.26e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs12477438 0.501 rs2632284 chr2:99775865 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.26 0.71 1.06e-41 Chronic sinus infection; CESC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg22143856 chr6:28129313 ZNF389 -0.47 -5.91 -0.34 1.05e-8 Depression; CESC cis rs425277 1.000 rs74877653 chr1:2065949 C/T cg23803603 chr1:2058230 PRKCZ 0.33 5.07 0.3 7.49e-7 Height; CESC cis rs7216064 1.000 rs73352808 chr17:65875157 G/A cg12091567 chr17:66097778 LOC651250 -0.79 -8.59 -0.47 7.61e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs17253792 0.915 rs77252471 chr14:56178075 C/T cg01858014 chr14:56050164 KTN1 -0.91 -7.03 -0.4 1.8e-11 Putamen volume; CESC cis rs9400271 0.632 rs9384706 chr6:109601504 C/T cg01475377 chr6:109611718 NA -0.45 -6.99 -0.39 2.28e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10827434 chr1:84944976 RPF1 -0.46 -6.15 -0.35 2.78e-9 Fibrinogen levels; CESC cis rs208520 0.661 rs1100950 chr6:66827285 A/C cg07460842 chr6:66804631 NA -1.0 -13.37 -0.63 1.62e-31 Exhaled nitric oxide output; CESC cis rs34779708 0.900 rs73262807 chr10:35496386 C/T cg04310649 chr10:35416472 CREM -0.52 -6.31 -0.36 1.18e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -7.51 -0.42 9.03e-13 Personality dimensions; CESC cis rs6547741 0.967 rs4665995 chr2:27813827 T/G cg27432699 chr2:27873401 GPN1 0.49 6.85 0.39 5.03e-11 Oral cavity cancer; CESC cis rs10504229 0.871 rs10504226 chr8:58159283 A/G cg02725872 chr8:58115012 NA -0.37 -5.72 -0.33 2.84e-8 Developmental language disorder (linguistic errors); CESC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg06074448 chr4:187884817 NA -0.38 -5.35 -0.31 1.91e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs9814567 1.000 rs9814567 chr3:134218557 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.44 6.2 0.36 2.13e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs727563 0.552 rs4822045 chr22:41985958 C/A cg06481639 chr22:41940642 POLR3H -0.65 -6.38 -0.37 7.65e-10 Crohn's disease;Inflammatory bowel disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13108601 chr6:41748242 FRS3;PRICKLE4 -0.43 -6.24 -0.36 1.73e-9 Gambling; CESC cis rs4974559 0.947 rs28437782 chr4:1355062 A/G cg02980000 chr4:1222292 CTBP1 0.71 6.6 0.38 2.28e-10 Systolic blood pressure; CESC cis rs1008375 0.933 rs7689101 chr4:17694034 G/A cg02297831 chr4:17616191 MED28 0.47 5.72 0.33 2.91e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6750795 0.569 rs1667313 chr2:232408018 A/C cg19187155 chr2:232395269 NMUR1 0.62 10.99 0.56 2.13e-23 Height; CESC cis rs601339 1.000 rs509548 chr12:123181855 T/A cg11919336 chr12:123188078 GPR109A 0.47 6.27 0.36 1.49e-9 Adiponectin levels; CESC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg12463550 chr7:65579703 CRCP 0.49 6.33 0.36 1.03e-9 Aortic root size; CESC cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg02297831 chr4:17616191 MED28 0.64 8.07 0.44 2.45e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3820928 0.874 rs7562776 chr2:227806550 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.66 -0.33 3.83e-8 Pulmonary function; CESC cis rs7267979 1.000 rs2259837 chr20:25280205 T/C cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs3942852 0.774 rs11039519 chr11:48130094 G/C cg15704280 chr7:45808275 SEPT13 -0.63 -7.33 -0.41 2.76e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs651907 0.514 rs10936744 chr3:101433440 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.88 0.34 1.22e-8 Colorectal cancer; CESC cis rs7647973 1.000 rs7613491 chr3:49508976 T/C cg06212747 chr3:49208901 KLHDC8B -0.56 -6.93 -0.39 3.22e-11 Menarche (age at onset); CESC trans rs5758511 0.773 rs8140869 chr22:42344297 A/G cg15080870 chr19:47770746 CCDC9 -0.49 -6.11 -0.35 3.48e-9 Birth weight; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04559647 chr10:126150293 LHPP 0.69 7.5 0.42 9.89e-13 Gut microbiome composition (summer); CESC trans rs637571 0.522 rs606978 chr11:65711517 A/C cg17712092 chr4:129076599 LARP1B 0.73 9.96 0.52 4.69e-20 Eosinophil percentage of white cells; CESC cis rs754466 1.000 rs754466 chr10:79680434 A/T cg17075019 chr10:79541650 NA -0.68 -8.91 -0.48 8.59e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs561341 0.883 rs72821942 chr17:30234460 C/T cg12193833 chr17:30244370 NA -0.61 -6.18 -0.36 2.36e-9 Hip circumference adjusted for BMI; CESC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg18099408 chr3:52552593 STAB1 -0.32 -5.34 -0.31 2e-7 Electroencephalogram traits; CESC cis rs11792861 0.566 rs6477687 chr9:111837791 A/T cg05043794 chr9:111880884 C9orf5 0.3 5.43 0.32 1.26e-7 Menarche (age at onset); CESC cis rs2011503 1.000 rs7256028 chr19:19628240 C/T cg11584989 chr19:19387371 SF4 0.56 6.6 0.38 2.18e-10 Bipolar disorder; CESC cis rs9430161 0.598 rs34350247 chr1:11034460 A/G cg02454025 chr1:11042201 C1orf127 0.99 16.16 0.7 2.35e-41 Ewing sarcoma; CESC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.42 -5.03 -0.3 8.85e-7 Height; CESC cis rs11792861 0.816 rs17792434 chr9:111667319 C/T cg05043794 chr9:111880884 C9orf5 -0.38 -6.38 -0.36 7.81e-10 Menarche (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00577569 chr7:66093764 KCTD7 -0.42 -6.54 -0.37 3.09e-10 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16351957 chr6:71874784 NA -0.6 -6.97 -0.39 2.53e-11 Gut microbiome composition (summer); CESC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg22143856 chr6:28129313 ZNF389 0.52 6.72 0.38 1.09e-10 Depression; CESC cis rs8077889 0.672 rs2074143 chr17:41856622 A/G cg26893861 chr17:41843967 DUSP3 1.01 18.74 0.76 1.74e-50 Triglycerides; CESC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg10862848 chr6:42927986 GNMT -0.27 -6.83 -0.39 5.91e-11 Alzheimer's disease in APOE e4+ carriers; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01538984 chr7:140396422 LOC100134713;NDUFB2 -0.42 -6.04 -0.35 5.22e-9 Gambling; CESC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg14262678 chr6:151773367 RMND1;C6orf211 0.66 9.39 0.5 2.91e-18 Menarche (age at onset); CESC cis rs763014 0.865 rs2018789 chr16:632051 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC cis rs9457247 1.000 rs400063 chr6:167386592 C/T cg07741184 chr6:167504864 NA 0.32 5.88 0.34 1.21e-8 Crohn's disease; CESC cis rs6459788 0.720 rs6965466 chr7:157250749 G/T cg06271696 chr7:157225062 NA -0.36 -5.13 -0.3 5.49e-7 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs3540 0.533 rs12916560 chr15:91056259 A/C cg10434728 chr15:90938212 IQGAP1 -0.4 -6.97 -0.39 2.51e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs2249625 0.874 rs2463747 chr6:72878113 T/A cg18830697 chr6:72922368 RIMS1 -0.39 -5.53 -0.32 7.83e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs9581857 0.556 rs9581863 chr13:28040171 A/G cg01674679 chr13:27998804 GTF3A -0.55 -5.89 -0.34 1.17e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs10504229 0.679 rs16921683 chr8:58053270 T/C cg22535103 chr8:58192502 C8orf71 -0.65 -7.25 -0.41 4.69e-12 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02963556 chr12:132588637 EP400NL -0.59 -6.6 -0.38 2.2e-10 Gut microbiome composition (summer); CESC cis rs71277158 0.688 rs3772186 chr3:169889331 A/T cg04067573 chr3:169899625 PHC3 -0.63 -6.51 -0.37 3.82e-10 Prostate cancer; CESC cis rs561341 1.000 rs498391 chr17:30328704 G/A cg12193833 chr17:30244370 NA -0.64 -5.98 -0.34 7.35e-9 Hip circumference adjusted for BMI; CESC cis rs7843479 0.601 rs1031882 chr8:21788934 T/G cg17168535 chr8:21777572 XPO7 0.8 13.33 0.63 2.3e-31 Mean corpuscular volume; CESC cis rs6831352 0.918 rs7670060 chr4:100059568 G/T cg12011299 chr4:100065546 ADH4 -0.59 -6.49 -0.37 4.3e-10 Alcohol dependence; CESC cis rs7116495 0.609 rs7126394 chr11:71685429 A/G cg18441811 chr11:71824068 C11orf51 -0.81 -5.3 -0.31 2.44e-7 Severe influenza A (H1N1) infection; CESC cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg06027949 chr8:82754900 SNX16 -0.44 -5.29 -0.31 2.58e-7 Diastolic blood pressure; CESC cis rs3733585 0.673 rs4314284 chr4:9956096 C/T cg02734326 chr4:10020555 SLC2A9 -0.38 -5.43 -0.32 1.3e-7 Cleft plate (environmental tobacco smoke interaction); CESC trans rs2727020 0.857 rs1917324 chr11:49371759 G/C cg03929089 chr4:120376271 NA -0.65 -7.61 -0.42 4.95e-13 Coronary artery disease; CESC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg06212747 chr3:49208901 KLHDC8B 0.73 11.06 0.56 1.29e-23 Menarche (age at onset); CESC cis rs7208859 0.673 rs11657270 chr17:29214387 A/G cg13385521 chr17:29058706 SUZ12P 0.66 5.03 0.3 9.15e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs1814175 0.645 rs11040699 chr11:50023798 C/G cg11707556 chr5:10655725 ANKRD33B -0.42 -6.13 -0.35 3.1e-9 Height; CESC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg15445000 chr17:37608096 MED1 -0.4 -6.55 -0.37 3.05e-10 Glomerular filtration rate (creatinine); CESC cis rs7107174 1.000 rs10899478 chr11:78052238 C/T cg02023728 chr11:77925099 USP35 0.38 5.4 0.31 1.47e-7 Testicular germ cell tumor; CESC trans rs11098499 0.874 rs17839089 chr4:120111069 A/G cg25214090 chr10:38739885 LOC399744 0.58 7.71 0.43 2.54e-13 Corneal astigmatism; CESC cis rs27434 0.660 rs27043 chr5:96117300 A/G cg16492584 chr5:96139282 ERAP1 0.49 5.92 0.34 9.97e-9 Ankylosing spondylitis; CESC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.53 -0.32 7.61e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.88e-10 Glomerular filtration rate (creatinine); CESC cis rs933688 1.000 rs6866191 chr5:90746852 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.94 11.09 0.56 1.03e-23 Smoking behavior; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19824897 chr13:79979916 RBM26 -0.44 -6.31 -0.36 1.14e-9 Gambling; CESC cis rs7020830 0.898 rs12000309 chr9:37230844 G/A cg14294708 chr9:37120828 ZCCHC7 1.24 24.36 0.83 1.35e-69 Schizophrenia; CESC cis rs1215050 0.791 rs260889 chr4:98742340 A/G cg05340658 chr4:99064831 C4orf37 0.51 6.65 0.38 1.63e-10 Waist-to-hip ratio adjusted for body mass index; CESC trans rs7726839 0.574 rs11134149 chr5:637277 A/G cg25482853 chr8:67687455 SGK3 0.93 9.77 0.51 1.86e-19 Obesity-related traits; CESC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg02353165 chr6:42928485 GNMT 0.84 13.25 0.63 4.46e-31 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9457247 1.000 rs364451 chr6:167384756 G/A cg23791538 chr6:167370224 RNASET2 -0.58 -8.33 -0.46 4.4e-15 Crohn's disease; CESC cis rs977987 0.843 rs62062564 chr16:75442622 G/A cg03315344 chr16:75512273 CHST6 0.4 5.83 0.34 1.57e-8 Dupuytren's disease; CESC cis rs72772090 0.539 rs11747896 chr5:96113397 A/G cg17330273 chr5:96107758 CAST;ERAP1 0.57 5.11 0.3 6.1e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06844209 chr11:66629644 PC -0.44 -6.07 -0.35 4.48e-9 Systemic lupus erythematosus; CESC cis rs7809950 1.000 rs12668402 chr7:107173020 G/A cg23024343 chr7:107201750 COG5 -0.41 -5.71 -0.33 3.03e-8 Coronary artery disease; CESC cis rs78132593 0.723 rs115291189 chr1:150675007 C/A cg04414720 chr1:150670196 GOLPH3L -0.51 -6.01 -0.35 6.17e-9 High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23659696 chr6:39083005 C6orf64 0.58 7.24 0.41 4.77e-12 Gut microbiome composition (summer); CESC cis rs9467711 0.606 rs9393712 chr6:26371000 G/C cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2455799 0.573 rs2455831 chr3:15751583 T/A cg09340198 chr3:15902540 ANKRD28 -0.33 -5.22 -0.31 3.57e-7 Mean platelet volume; CESC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.82 -0.34 1.73e-8 Parkinson's disease; CESC cis rs2573652 0.722 rs8034841 chr15:100541593 G/T cg09918751 chr15:100517450 ADAMTS17 -0.32 -5.95 -0.34 8.48e-9 Height; CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg17221315 chr6:27791827 HIST1H4J 0.45 5.07 0.3 7.46e-7 Depression; CESC cis rs7188697 0.922 rs37040 chr16:58578262 T/C cg21335942 chr16:58549945 SETD6 0.46 5.48 0.32 1.01e-7 QT interval; CESC cis rs6691722 0.503 rs3765432 chr1:24706461 A/G cg18323236 chr1:24743029 NIPAL3 0.37 5.55 0.32 7.02e-8 Response to interferon beta in multiple sclerosis; CESC cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg01475377 chr6:109611718 NA -0.5 -8.41 -0.46 2.52e-15 Reticulocyte fraction of red cells; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg23495556 chr7:44836196 PPIA -0.5 -6.78 -0.38 7.95e-11 Recombination measurement; CESC trans rs7746199 0.736 rs58616630 chr6:27474715 A/G cg01620082 chr3:125678407 NA -0.79 -6.42 -0.37 6.38e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13995389 chr5:132202281 UQCRQ 0.55 6.34 0.36 9.65e-10 Gut microbiome composition (summer); CESC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg10800226 chr5:1850261 NA 0.34 5.67 0.33 3.65e-8 Cardiovascular disease risk factors; CESC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg14583973 chr4:3374767 RGS12 0.31 5.43 0.32 1.29e-7 Serum sulfate level; CESC cis rs7937682 0.710 rs674230 chr11:111437887 A/G cg09085632 chr11:111637200 PPP2R1B -0.97 -14.3 -0.66 8.89e-35 Primary sclerosing cholangitis; CESC cis rs12887734 0.569 rs66953418 chr14:104271470 G/A cg08213375 chr14:104286397 PPP1R13B 0.41 6.8 0.39 7.09e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg24818145 chr4:99064322 C4orf37 0.39 5.13 0.3 5.69e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3020736 0.500 rs5996110 chr22:42493767 A/G cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC cis rs1348850 0.789 rs2197611 chr2:178369036 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.87 12.61 0.61 7.17e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs12410462 0.792 rs994666 chr1:227651454 C/T cg23173402 chr1:227635558 NA -0.55 -5.52 -0.32 7.94e-8 Major depressive disorder; CESC trans rs801193 0.967 rs34356500 chr7:66236607 G/T cg26939375 chr7:64535504 NA 0.67 9.01 0.48 4.12e-17 Aortic root size; CESC cis rs16867321 0.627 rs6730229 chr2:181579985 A/C cg23363182 chr2:181467187 NA 0.44 6.5 0.37 3.86e-10 Obesity; CESC cis rs1008375 0.932 rs4698650 chr4:17692878 G/C cg02297831 chr4:17616191 MED28 0.46 5.62 0.33 4.91e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg16606324 chr3:10149918 C3orf24 0.45 5.37 0.31 1.69e-7 Alzheimer's disease; CESC cis rs2282802 0.660 rs2436390 chr5:139586501 G/A cg26211634 chr5:139558579 C5orf32 -0.49 -7.19 -0.4 6.76e-12 Intelligence (multi-trait analysis); CESC cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg12927641 chr6:109611667 NA -0.41 -6.43 -0.37 5.98e-10 Reticulocyte fraction of red cells; CESC cis rs7666738 0.830 rs7696686 chr4:98938445 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg02931644 chr1:25747376 RHCE 0.47 7.96 0.44 5.1e-14 Plateletcrit;Mean corpuscular volume; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg00147976 chr12:53846229 PCBP2 0.47 6.43 0.37 5.75e-10 Thyroid stimulating hormone; CESC cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg20887711 chr4:1340912 KIAA1530 0.47 6.28 0.36 1.41e-9 Longevity; CESC trans rs61931739 0.500 rs7489270 chr12:34432062 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.3 0.36 1.24e-9 Morning vs. evening chronotype; CESC cis rs16910800 0.731 rs1065631 chr11:23186810 T/C cg20040320 chr11:23191996 NA -0.67 -6.66 -0.38 1.53e-10 Cancer; CESC cis rs2929278 0.617 rs693919 chr15:44102328 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -7.29 -0.41 3.59e-12 Schizophrenia; CESC cis rs1707322 0.964 rs785516 chr1:46564758 T/G cg06784218 chr1:46089804 CCDC17 -0.36 -5.93 -0.34 9.35e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6696846 0.777 rs2369526 chr1:205054406 C/T cg00857998 chr1:205179979 DSTYK 0.47 6.33 0.36 1.01e-9 Red blood cell count; CESC cis rs965513 0.901 rs7045465 chr9:100534823 A/T cg13688889 chr9:100608707 NA -0.45 -6.43 -0.37 5.86e-10 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13190986 chr12:133263482 PXMP2;POLE 0.5 6.32 0.36 1.07e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs36207871 1 rs36207871 chr12:56684496 TAGGAA/T cg26316697 chr12:56727976 PAN2 -0.69 -6.64 -0.38 1.74e-10 Inflammatory skin disease; CESC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg09455208 chr3:40491958 NA 0.53 8.86 0.48 1.15e-16 Renal cell carcinoma; CESC cis rs6942756 1.000 rs66970518 chr7:128871006 G/A cg02491457 chr7:128862824 NA -0.72 -10.44 -0.54 1.31e-21 White matter hyperintensity burden; CESC cis rs17666538 0.636 rs10107345 chr8:603700 G/T cg23958373 chr8:599963 NA 0.74 6.33 0.36 1.05e-9 IgG glycosylation; CESC cis rs798766 1.000 rs1665366 chr4:1728381 A/G cg10756475 chr4:1757242 NA -0.46 -5.76 -0.33 2.28e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs9462846 0.959 rs10456518 chr6:42830484 G/A cg02353165 chr6:42928485 GNMT 0.45 5.18 0.3 4.45e-7 Blood protein levels; CESC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 7.2 0.4 6.18e-12 Depression; CESC cis rs3857536 0.813 rs7769683 chr6:66946256 G/A cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs919433 1.000 rs6741380 chr2:198165121 A/G cg10820045 chr2:198174542 NA 0.38 5.75 0.33 2.4e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7044106 0.708 rs10760113 chr9:123474050 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.72 10.59 0.55 4.52e-22 Hip circumference adjusted for BMI; CESC cis rs8114671 0.562 rs6088622 chr20:33419977 C/A cg24642439 chr20:33292090 TP53INP2 0.46 5.45 0.32 1.14e-7 Height; CESC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg26939375 chr7:64535504 NA 0.76 10.78 0.55 1.03e-22 Calcium levels; CESC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg19622623 chr12:86230825 RASSF9 -0.47 -6.14 -0.35 3.04e-9 Major depressive disorder; CESC cis rs9393777 0.841 rs13191474 chr6:27413345 C/T cg26587870 chr6:27730563 NA -0.7 -5.13 -0.3 5.48e-7 Intelligence (multi-trait analysis); CESC cis rs60843830 1.000 rs57542652 chr2:228088 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.78 9.67 0.51 3.87e-19 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1707322 0.686 rs1541131 chr1:46084934 G/A cg05343316 chr1:45956843 TESK2 -0.49 -5.96 -0.34 8.16e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs308403 0.568 rs309344 chr4:123644812 G/A cg18677716 chr21:47865349 PCNT -0.47 -6.06 -0.35 4.69e-9 Blood protein levels; CESC cis rs10818894 1.000 rs10818894 chr9:126695770 A/G cg16191174 chr9:126692580 DENND1A -0.62 -8.15 -0.45 1.45e-14 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); CESC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8062405 0.755 rs17640009 chr16:28595700 A/G cg01378222 chr16:28622494 SULT1A1 0.31 5.24 0.31 3.33e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg08470875 chr2:26401718 FAM59B -0.47 -5.23 -0.31 3.38e-7 Gut microbiome composition (summer); CESC cis rs2455826 0.500 rs2455852 chr3:15688688 C/T cg16303742 chr3:15540471 COLQ -0.5 -8.1 -0.45 2.05e-14 Inflammatory skin disease; CESC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg20887711 chr4:1340912 KIAA1530 -0.66 -8.89 -0.48 9.87e-17 Obesity-related traits; CESC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg26119090 chr2:26468346 HADHA;HADHB 1.08 12.83 0.62 1.2e-29 Gut microbiome composition (summer); CESC cis rs644799 0.710 rs11021311 chr11:95505227 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.77 11.31 0.57 1.91e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10465746 0.967 rs1475263 chr1:84339497 A/T cg10977910 chr1:84465055 TTLL7 0.48 6.52 0.37 3.64e-10 Obesity-related traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15239874 chr12:121148841 UNC119B -0.47 -6.82 -0.39 6.09e-11 Gambling; CESC cis rs9287719 0.810 rs1990612 chr2:10781944 A/G cg00105475 chr2:10696890 NA 0.36 5.17 0.3 4.67e-7 Prostate cancer; CESC cis rs2299587 0.521 rs3739406 chr8:17739538 T/C cg08627089 chr8:17753878 FGL1 -0.39 -5.56 -0.32 6.63e-8 Economic and political preferences; CESC cis rs9486715 0.830 rs4425602 chr6:96893906 G/A cg18709589 chr6:96969512 KIAA0776 0.45 6.3 0.36 1.22e-9 Headache; CESC cis rs7772486 0.743 rs62433835 chr6:146032688 C/G cg05347473 chr6:146136440 FBXO30 -0.48 -6.45 -0.37 5.16e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs796364 0.806 rs6435041 chr2:200867144 A/G cg23649088 chr2:200775458 C2orf69 0.6 5.3 0.31 2.44e-7 Schizophrenia; CESC cis rs8050907 0.744 rs7192051 chr16:4542117 A/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.76 5.74 0.33 2.6e-8 Obesity-related traits; CESC cis rs9811920 0.715 rs1017967 chr3:99905803 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.38 5.84 0.34 1.51e-8 Axial length; CESC cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg06636001 chr8:8085503 FLJ10661 0.53 6.43 0.37 5.75e-10 Mood instability; CESC cis rs1008375 0.933 rs7689101 chr4:17694034 G/A cg16339924 chr4:17578868 LAP3 0.58 7.08 0.4 1.33e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg13628971 chr7:2884303 GNA12 0.63 8.31 0.45 4.89e-15 Height; CESC cis rs1062177 1.000 rs12653926 chr5:151250248 C/A cg12924095 chr5:151150029 G3BP1 0.47 6.01 0.35 6.01e-9 Preschool internalizing problems; CESC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg13206674 chr6:150067644 NUP43 -0.42 -5.85 -0.34 1.43e-8 Lung cancer; CESC cis rs7927771 0.524 rs11039392 chr11:47798753 A/G cg20307385 chr11:47447363 PSMC3 0.62 8.69 0.47 3.96e-16 Subjective well-being; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg07151637 chr22:32149913 DEPDC5 0.46 6.19 0.36 2.29e-9 Breast cancer;Type 2 diabetes; CESC cis rs17384381 0.906 rs2300639 chr1:85823676 T/A cg16011679 chr1:85725395 C1orf52 0.83 8.44 0.46 2.15e-15 Lobe attachment (rater-scored or self-reported); CESC cis rs7586673 0.893 rs889925 chr2:161971597 T/C cg16506815 chr2:162101123 NA 0.42 5.83 0.34 1.63e-8 Intelligence (multi-trait analysis); CESC cis rs7000551 0.725 rs2461483 chr8:22386479 C/T cg12081754 chr8:22256438 SLC39A14 0.41 5.41 0.32 1.43e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs17253792 0.822 rs79483507 chr14:56164718 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg13770153 chr20:60521292 NA -0.46 -5.88 -0.34 1.23e-8 Body mass index; CESC cis rs12478296 0.786 rs6721704 chr2:242994923 A/G cg06360820 chr2:242988706 NA -0.74 -9.37 -0.5 3.4e-18 Obesity-related traits; CESC cis rs6582630 0.502 rs11181210 chr12:38298069 G/A cg13010199 chr12:38710504 ALG10B 0.46 5.88 0.34 1.26e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs8058578 1.000 rs6565197 chr16:30706477 T/C cg00531865 chr16:30841666 NA -0.44 -5.84 -0.34 1.51e-8 Multiple myeloma; CESC cis rs2075371 0.796 rs1643040 chr7:134011703 G/C cg11752832 chr7:134001865 SLC35B4 0.48 6.0 0.35 6.58e-9 Mean platelet volume; CESC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.21 0.36 2.01e-9 Menopause (age at onset); CESC cis rs2932538 0.922 rs12136781 chr1:113090655 C/T cg22162597 chr1:113214053 CAPZA1 0.56 7.01 0.4 1.96e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg01988459 chr11:68622903 NA -0.45 -6.36 -0.36 8.85e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11674184 0.632 rs17529680 chr2:11727087 A/C cg07314298 chr2:11723111 GREB1 0.59 8.64 0.47 5.5e-16 Endometriosis; CESC cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg18876405 chr7:65276391 NA -0.49 -5.44 -0.32 1.24e-7 Aortic root size; CESC cis rs9796 0.662 rs8033435 chr15:41436479 C/T cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.74 -0.38 1e-10 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24546153 chr1:203830887 SNRPE -0.51 -6.25 -0.36 1.6e-9 Ulcerative colitis; CESC cis rs13102973 0.899 rs10213137 chr4:135900543 T/C cg14419869 chr4:135874104 NA -0.34 -5.17 -0.3 4.69e-7 Subjective well-being; CESC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg22963979 chr7:1858916 MAD1L1 -0.39 -5.43 -0.32 1.28e-7 Bipolar disorder and schizophrenia; CESC cis rs3768617 0.706 rs6678517 chr1:183002639 A/G ch.1.3577855R chr1:183094577 LAMC1 0.7 9.99 0.52 3.8e-20 Fuchs's corneal dystrophy; CESC cis rs9488822 0.676 rs12524249 chr6:116368813 G/A cg05304507 chr6:116381966 FRK 0.26 6.75 0.38 9.45e-11 Cholesterol, total;LDL cholesterol; CESC cis rs7917772 0.502 rs2296583 chr10:104244322 T/G cg22532475 chr10:104410764 TRIM8 -0.33 -5.65 -0.33 4.1e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg19346786 chr7:2764209 NA -0.46 -6.71 -0.38 1.16e-10 Height; CESC cis rs60733400 0.644 rs28774982 chr1:2621352 C/G cg18854424 chr1:2615690 NA -0.3 -5.64 -0.33 4.25e-8 Multiple sclerosis; CESC cis rs3796352 1.000 rs34244302 chr3:53102236 C/G cg07884673 chr3:53033167 SFMBT1 0.67 5.67 0.33 3.66e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg05283184 chr6:79620031 NA -0.43 -6.55 -0.37 2.95e-10 Intelligence (multi-trait analysis); CESC cis rs17376456 0.877 rs10062711 chr5:93348659 G/A cg21475434 chr5:93447410 FAM172A 0.79 7.01 0.4 1.95e-11 Diabetic retinopathy; CESC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg07167872 chr1:205819463 PM20D1 -0.43 -6.03 -0.35 5.35e-9 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs11098499 0.863 rs11731756 chr4:120478696 T/G cg09307838 chr4:120376055 NA 0.9 12.45 0.61 2.6e-28 Corneal astigmatism; CESC cis rs1559088 0.600 rs7259117 chr19:33550113 G/T cg03563238 chr19:33554763 RHPN2 -0.32 -5.81 -0.34 1.8e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4268898 0.610 rs72791170 chr2:24449776 C/T cg06627628 chr2:24431161 ITSN2 -0.99 -11.27 -0.57 2.58e-24 Asthma; CESC trans rs208520 0.955 rs12216176 chr6:67005130 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 8.46 0.46 1.85e-15 Exhaled nitric oxide output; CESC cis rs11696501 0.588 rs6073831 chr20:44279550 A/T cg11783356 chr20:44313418 WFDC10B -0.33 -5.16 -0.3 4.82e-7 Brain structure; CESC cis rs34779708 0.931 rs7923172 chr10:35309367 G/A cg03585969 chr10:35415529 CREM 0.75 10.02 0.52 2.93e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6061231 0.631 rs2427317 chr20:60975725 C/T cg22633769 chr20:60982531 CABLES2 0.56 7.21 0.4 5.96e-12 Colorectal cancer; CESC cis rs10887741 0.690 rs10509410 chr10:89440001 C/T cg13926569 chr10:89418898 PAPSS2 0.37 5.57 0.32 6.15e-8 Exercise (leisure time); CESC cis rs1144333 1.000 rs1586936 chr1:76366877 T/C cg10523679 chr1:76189770 ACADM 0.56 5.2 0.3 3.94e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs208520 1.000 rs12209225 chr6:66996443 G/T cg07460842 chr6:66804631 NA 0.87 9.84 0.52 1.09e-19 Exhaled nitric oxide output; CESC cis rs208520 0.770 rs2153941 chr6:66885521 A/T cg07460842 chr6:66804631 NA -0.94 -12.15 -0.6 2.75e-27 Exhaled nitric oxide output; CESC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg13206674 chr6:150067644 NUP43 0.45 6.47 0.37 4.75e-10 Lung cancer; CESC cis rs11677416 0.961 rs1894399 chr2:113540177 C/T cg27083787 chr2:113543245 IL1A 0.41 5.17 0.3 4.65e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs6546537 0.550 rs12617329 chr2:69781530 C/A cg10773587 chr2:69614142 GFPT1 -0.43 -5.48 -0.32 1.01e-7 Serum thyroid-stimulating hormone levels; CESC cis rs4253772 0.591 rs73886791 chr22:46687212 A/G cg09491104 chr22:46646882 C22orf40 -0.63 -9.37 -0.5 3.4e-18 LDL cholesterol;Cholesterol, total; CESC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg21782813 chr7:2030301 MAD1L1 0.41 5.87 0.34 1.31e-8 Bipolar disorder and schizophrenia; CESC cis rs7828089 0.582 rs13259873 chr8:22266292 C/T cg12081754 chr8:22256438 SLC39A14 0.64 9.0 0.48 4.4e-17 Verbal declarative memory; CESC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.93 0.44 6.13e-14 Electroencephalogram traits; CESC cis rs3820068 0.705 rs11577225 chr1:15864242 T/C cg18192808 chr1:15853278 DNAJC16 0.43 5.28 0.31 2.66e-7 Systolic blood pressure; CESC cis rs826838 0.904 rs10876086 chr12:39188208 C/A cg13010199 chr12:38710504 ALG10B 0.58 8.05 0.44 2.77e-14 Heart rate; CESC cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.87 0.34 1.3e-8 Hip circumference adjusted for BMI; CESC cis rs72634258 0.842 rs4908727 chr1:8163122 C/T cg00042356 chr1:8021962 PARK7 0.48 5.16 0.3 4.95e-7 Inflammatory bowel disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17103929 chr8:101225361 SPAG1 0.48 6.15 0.35 2.9e-9 Gut microbiota (bacterial taxa); CESC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg04944784 chr2:26401820 FAM59B -0.66 -7.63 -0.42 4.16e-13 Gut microbiome composition (summer); CESC cis rs2108622 0.727 rs62106156 chr19:15980424 C/T cg13772218 chr19:15982569 NA 0.29 5.71 0.33 3.02e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs7216064 1.000 rs35243555 chr17:65876477 G/C cg07042672 chr17:66097459 LOC651250 -0.52 -5.4 -0.31 1.5e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg05861140 chr6:150128134 PCMT1 -0.35 -5.03 -0.3 8.87e-7 Lung cancer; CESC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg12463550 chr7:65579703 CRCP -0.55 -7.18 -0.4 7.17e-12 Aortic root size; CESC cis rs116095464 0.558 rs62346508 chr5:203668 T/C cg22857025 chr5:266934 NA -1.28 -14.06 -0.65 6.33e-34 Breast cancer; CESC cis rs76419734 0.510 rs12504088 chr4:106662004 A/G cg24545054 chr4:106630052 GSTCD;INTS12 0.72 8.76 0.47 2.42e-16 Post bronchodilator FEV1; CESC cis rs7851660 0.809 rs7048255 chr9:100665698 A/G cg13688889 chr9:100608707 NA -0.63 -8.95 -0.48 6.33e-17 Strep throat; CESC cis rs9863 0.862 rs6488912 chr12:124442752 T/C cg17562584 chr12:124393655 DNAH10 0.33 5.66 0.33 3.98e-8 White blood cell count; CESC cis rs7193541 0.691 rs3851728 chr16:74480660 C/T cg01733217 chr16:74700730 RFWD3 0.68 9.52 0.5 1.12e-18 Multiple myeloma; CESC cis rs9929218 0.954 rs4485355 chr16:68754730 C/T cg02972257 chr16:68554789 NA 0.54 6.26 0.36 1.52e-9 Colorectal cancer; CESC cis rs1018836 0.923 rs4735230 chr8:91574184 G/C cg16814680 chr8:91681699 NA -0.72 -10.32 -0.54 3.27e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1707322 1.000 rs11211239 chr1:46451947 A/G cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8013055 0.706 rs8003957 chr14:105971702 A/G cg23356831 chr14:105996513 TMEM121 0.38 5.12 0.3 5.98e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC cis rs965469 1.000 rs2236104 chr20:3277602 C/A cg25506879 chr20:3388711 C20orf194 -0.54 -5.88 -0.34 1.24e-8 IFN-related cytopenia; CESC cis rs12971120 0.947 rs8084410 chr18:72168486 T/C cg26446133 chr18:72167187 CNDP2 -0.75 -11.21 -0.57 4.12e-24 Refractive error; CESC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -7.03 -0.4 1.8e-11 Extrinsic epigenetic age acceleration; CESC trans rs561341 1.000 rs548957 chr17:30302411 G/A cg27661571 chr11:113659931 NA -0.83 -7.76 -0.43 1.9e-13 Hip circumference adjusted for BMI; CESC cis rs11711311 0.955 rs9860642 chr3:113419211 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.66 8.94 0.48 7e-17 IgG glycosylation; CESC trans rs11098499 0.865 rs28845498 chr4:120405186 G/A cg25214090 chr10:38739885 LOC399744 0.72 10.18 0.53 9.16e-21 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16699849 chr7:98923489 ARPC1A 0.54 6.36 0.36 8.57e-10 Gut microbiome composition (summer); CESC trans rs561341 0.941 rs72825746 chr17:30364610 G/A cg27661571 chr11:113659931 NA -0.87 -7.99 -0.44 4.25e-14 Hip circumference adjusted for BMI; CESC cis rs7667 1.000 rs10799805 chr1:19707951 C/T cg15026089 chr1:19640712 PQLC2 -0.31 -5.12 -0.3 5.84e-7 Crohn's disease and psoriasis; CESC cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.66 0.61 4.8e-29 Colonoscopy-negative controls vs population controls; CESC cis rs1355223 0.902 rs1901831 chr11:34725175 C/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.2 -0.36 2.18e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg22907277 chr7:1156413 C7orf50 0.46 5.4 0.32 1.45e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.39 -0.37 7.41e-10 Depression; CESC cis rs733175 0.855 rs10022499 chr4:10006537 C/A cg00071950 chr4:10020882 SLC2A9 0.57 6.69 0.38 1.32e-10 Psychosis and Alzheimer's disease; CESC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg03433033 chr1:76189801 ACADM 0.63 7.35 0.41 2.5e-12 Blood metabolite levels;Acylcarnitine levels; CESC trans rs877282 0.853 rs7092652 chr10:756109 G/A cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14115740 chr9:98054883 FANCC 0.52 6.97 0.39 2.57e-11 Fibrinogen levels; CESC cis rs6537837 1.000 rs7371 chr1:110135308 G/A cg05049280 chr1:110155535 GNAT2 0.38 5.34 0.31 1.96e-7 Major depressive disorder; CESC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg08968635 chr6:28129556 ZNF389 0.4 5.26 0.31 3e-7 Depression; CESC trans rs801193 1.000 rs2659889 chr7:66217112 A/G cg26939375 chr7:64535504 NA 0.64 8.67 0.47 4.31e-16 Aortic root size; CESC cis rs34779708 1.000 rs12769189 chr10:35399668 A/G cg04310649 chr10:35416472 CREM -0.53 -6.38 -0.37 7.66e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg00684032 chr4:1343700 KIAA1530 0.39 5.46 0.32 1.11e-7 Obesity-related traits; CESC cis rs3741151 0.686 rs60860405 chr11:73248673 A/C cg17517138 chr11:73019481 ARHGEF17 0.57 5.06 0.3 7.75e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs1814175 0.645 rs866427 chr11:49923853 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs6032067 0.929 rs13039108 chr20:43829584 T/C cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.57e-7 Blood protein levels; CESC cis rs3740540 0.530 rs10794163 chr10:126291398 A/G cg04949429 chr10:126290192 LHPP 0.4 5.61 0.33 5.04e-8 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg25036284 chr2:26402008 FAM59B 0.85 8.95 0.48 6.29e-17 Gut microbiome composition (summer); CESC trans rs875971 1.000 rs6979382 chr7:65886375 C/T cg26939375 chr7:64535504 NA 0.47 6.04 0.35 5.14e-9 Aortic root size; CESC cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.82e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7116495 1.000 rs560777 chr11:71770602 C/T cg26138937 chr11:71823887 C11orf51 0.84 7.18 0.4 7.24e-12 Severe influenza A (H1N1) infection; CESC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.4 5.27 0.31 2.86e-7 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01588546 chr19:1104635 GPX4 0.54 6.07 0.35 4.42e-9 Gut microbiome composition (summer); CESC cis rs7123876 0.504 rs1157343 chr11:72429141 A/G cg03713592 chr11:72463424 ARAP1 -0.44 -5.31 -0.31 2.34e-7 Body mass index; CESC cis rs11098499 0.820 rs11737395 chr4:120520704 C/G cg09307838 chr4:120376055 NA 0.92 12.45 0.61 2.6e-28 Corneal astigmatism; CESC cis rs1401999 1.000 rs939337 chr3:183701147 G/C cg01324343 chr3:183735012 ABCC5 0.64 13.63 0.64 2.08e-32 Anterior chamber depth; CESC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg17724175 chr1:150552817 MCL1 0.43 6.92 0.39 3.42e-11 Tonsillectomy; CESC cis rs4481887 0.854 rs4534423 chr1:248474993 G/C cg00666640 chr1:248458726 OR2T12 0.34 5.62 0.33 4.8e-8 Common traits (Other); CESC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg18876405 chr7:65276391 NA -0.53 -7.28 -0.41 3.9e-12 Aortic root size; CESC cis rs2050392 0.965 rs2265371 chr10:30690840 C/T cg18806716 chr10:30721971 MAP3K8 -0.4 -5.66 -0.33 3.91e-8 Inflammatory bowel disease; CESC cis rs3106136 0.967 rs2087170 chr4:95162960 A/C cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.15 -0.4 8.38e-12 Capecitabine sensitivity; CESC cis rs7909791 0.632 rs3752948 chr10:105670762 G/A cg24587175 chr10:105670608 OBFC1 0.42 5.86 0.34 1.4e-8 White matter hyperintensity burden; CESC cis rs8050907 0.744 rs8055559 chr16:4540227 A/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.89 6.22 0.36 1.94e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05373286 chr10:76969678 VDAC2 0.61 7.08 0.4 1.32e-11 Gut microbiome composition (summer); CESC cis rs9811920 0.638 rs10936008 chr3:99686665 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -5.49 -0.32 9.31e-8 Axial length; CESC cis rs7662987 0.517 rs2602876 chr4:100039535 A/T cg12011299 chr4:100065546 ADH4 0.54 6.02 0.35 5.91e-9 Smoking initiation; CESC cis rs6088590 0.561 rs6087600 chr20:33157217 T/C cg06115741 chr20:33292138 TP53INP2 0.5 6.49 0.37 4.16e-10 Coronary artery disease; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg15525503 chr1:3773166 DFFB;KIAA0562 0.44 6.01 0.35 6.06e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs8114671 0.836 rs6142280 chr20:33622242 A/C cg24642439 chr20:33292090 TP53INP2 -0.47 -5.64 -0.33 4.27e-8 Height; CESC trans rs324780 0.544 rs2201718 chr12:83925736 T/C cg22140261 chr22:42466895 NAGA -0.48 -6.12 -0.35 3.34e-9 Vertical cup-disc ratio; CESC cis rs1375194 0.582 rs4670735 chr2:33801456 C/T cg04131969 chr2:33951647 MYADML -0.51 -6.5 -0.37 4.02e-10 Response to antidepressants in depression; CESC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg22823121 chr1:150693482 HORMAD1 -0.45 -6.42 -0.37 6.25e-10 Urate levels; CESC cis rs274567 0.599 rs11242110 chr5:131743777 A/C cg07395648 chr5:131743802 NA 0.63 9.25 0.49 7.67e-18 Blood metabolite levels; CESC trans rs3749237 1.000 rs1317140 chr3:49878652 G/A cg21659725 chr3:3221576 CRBN 0.55 6.45 0.37 5.38e-10 Resting heart rate; CESC cis rs113835537 0.529 rs2305533 chr11:66298623 A/C cg22134325 chr11:66188745 NPAS4 0.39 5.94 0.34 8.94e-9 Airway imaging phenotypes; CESC cis rs208520 0.955 rs208532 chr6:66961280 T/A cg07460842 chr6:66804631 NA -0.9 -10.34 -0.54 2.79e-21 Exhaled nitric oxide output; CESC cis rs3781458 0.803 rs10901793 chr10:126324209 G/A cg20435097 chr10:126320824 FAM53B 0.3 5.22 0.31 3.69e-7 Male-pattern baldness; CESC cis rs9916302 0.904 rs7210488 chr17:37539819 T/G cg20243544 chr17:37824526 PNMT -0.51 -6.44 -0.37 5.46e-10 Glomerular filtration rate (creatinine); CESC cis rs7267979 0.966 rs6037097 chr20:25347221 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.88 18.2 0.75 1.43e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg26939375 chr7:64535504 NA 0.77 11.14 0.56 6.68e-24 Aortic root size; CESC cis rs2191566 0.664 rs4482396 chr19:44562000 C/T cg20607764 chr19:44506953 ZNF230 -0.44 -5.64 -0.33 4.34e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.33 0.41 2.84e-12 Prudent dietary pattern; CESC cis rs2455799 0.613 rs2470548 chr3:15737689 G/A cg16303742 chr3:15540471 COLQ -0.33 -5.13 -0.3 5.62e-7 Mean platelet volume; CESC cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg02297831 chr4:17616191 MED28 0.62 7.96 0.44 4.97e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7208859 0.673 rs55658077 chr17:29156519 A/G cg19761014 chr17:28927070 LRRC37B2 0.74 6.03 0.35 5.43e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10883723 0.810 rs7094366 chr10:104274730 C/G cg22532475 chr10:104410764 TRIM8 -0.33 -5.34 -0.31 2e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg05863683 chr7:1912471 MAD1L1 0.44 6.62 0.38 1.98e-10 Bipolar disorder and schizophrenia; CESC cis rs7945705 0.869 rs4909952 chr11:8963946 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.5 8.13 0.45 1.63e-14 Hemoglobin concentration; CESC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.38 0.31 1.66e-7 Tonsillectomy; CESC cis rs10979 1.000 rs12738 chr6:143890049 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs4722166 0.630 rs13311199 chr7:22789793 A/C cg13104385 chr7:22767384 IL6 0.49 6.56 0.37 2.81e-10 Lung cancer; CESC cis rs910316 0.763 rs175435 chr14:75612025 A/G cg11812906 chr14:75593930 NEK9 0.8 12.82 0.62 1.38e-29 Height; CESC cis rs1387259 0.931 rs1107654 chr12:48681097 T/G cg24011408 chr12:48396354 COL2A1 0.43 6.07 0.35 4.46e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23231910 chr2:202899550 FZD7 -0.53 -6.18 -0.35 2.45e-9 Gut microbiome composition (summer); CESC cis rs2066819 1.000 rs76745316 chr12:56627652 A/C cg26804944 chr12:56660921 COQ10A -0.86 -5.22 -0.31 3.69e-7 Psoriasis vulgaris; CESC cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.47 0.46 1.72e-15 Colonoscopy-negative controls vs population controls; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg06710522 chr17:45908972 MRPL10;LRRC46 -0.49 -6.01 -0.35 6.25e-9 Lung cancer in ever smokers; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19719329 chr22:46727417 NA 0.46 6.01 0.35 5.97e-9 Fibrinogen levels; CESC cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg22875332 chr1:76189707 ACADM 0.69 9.24 0.49 8.13e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7264396 0.747 rs2425158 chr20:34419664 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.51 0.42 9.34e-13 Total cholesterol levels; CESC cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg27347728 chr4:17578864 LAP3 0.46 5.49 0.32 9.24e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19683457 chr6:105307726 HACE1 -0.46 -6.35 -0.36 9.29e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg16325326 chr1:53192061 ZYG11B 0.92 16.14 0.7 2.8e-41 Monocyte count; CESC cis rs17376456 0.877 rs2085960 chr5:93399934 A/G cg21475434 chr5:93447410 FAM172A 0.79 6.96 0.39 2.71e-11 Diabetic retinopathy; CESC cis rs1881797 0.872 rs2141544 chr1:247690800 A/G cg11166453 chr1:247681781 NA 0.46 6.88 0.39 4.35e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs4481887 0.927 rs6678798 chr1:248476617 C/T cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs11098499 0.691 rs12502524 chr4:120271414 G/A cg09307838 chr4:120376055 NA 0.77 10.19 0.53 8.72e-21 Corneal astigmatism; CESC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg27057461 chr7:158136379 PTPRN2 -0.33 -5.17 -0.3 4.6e-7 Calcium levels; CESC cis rs4481887 0.927 rs4586010 chr1:248437568 G/A cg00666640 chr1:248458726 OR2T12 0.4 6.7 0.38 1.26e-10 Common traits (Other); CESC cis rs910316 1.000 rs876403 chr14:75602834 A/T cg08847533 chr14:75593920 NEK9 1.01 19.64 0.77 1.26e-53 Height; CESC cis rs763121 0.853 rs2064088 chr22:39053382 A/G cg06544989 chr22:39130855 UNC84B 0.49 8.52 0.46 1.22e-15 Menopause (age at onset); CESC cis rs9487051 0.714 rs9386797 chr6:109632520 C/A cg21918786 chr6:109611834 NA -0.39 -5.71 -0.33 3.06e-8 Reticulocyte fraction of red cells; CESC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 11.43 0.57 7.11e-25 Platelet count; CESC cis rs13191362 0.507 rs6907151 chr6:163200701 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.47 5.53 0.32 7.67e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3125734 0.633 rs4979774 chr10:63967795 A/T cg09941381 chr10:64027924 RTKN2 -0.33 -5.49 -0.32 9.39e-8 Rheumatoid arthritis; CESC cis rs7551222 0.752 rs4252687 chr1:204497335 G/C cg20240347 chr1:204465584 NA -0.28 -5.64 -0.33 4.33e-8 Schizophrenia; CESC cis rs7267979 0.966 rs2257461 chr20:25265554 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs7772486 0.875 rs2777476 chr6:146345024 A/G cg23711669 chr6:146136114 FBXO30 0.86 12.53 0.61 1.39e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs6088580 0.609 rs6059844 chr20:33036482 A/G cg24642439 chr20:33292090 TP53INP2 0.51 6.8 0.39 6.97e-11 Glomerular filtration rate (creatinine); CESC cis rs3093024 0.595 rs4412174 chr6:167476066 A/G cg23791538 chr6:167370224 RNASET2 -0.52 -6.9 -0.39 3.81e-11 Rheumatoid arthritis; CESC cis rs17539620 0.624 rs7770107 chr6:154836862 A/G cg20019720 chr6:154832845 CNKSR3 0.47 6.13 0.35 3.21e-9 Lipoprotein (a) levels; CESC cis rs2952156 0.920 rs1018246 chr17:37835240 C/T cg07936489 chr17:37558343 FBXL20 -0.61 -8.1 -0.45 2.04e-14 Asthma; CESC cis rs9611565 0.918 rs12484074 chr22:41752747 G/A cg03806693 chr22:41940476 POLR3H -1.04 -11.81 -0.59 3.87e-26 Vitiligo; CESC cis rs25645 0.823 rs12453334 chr17:38153473 C/T cg17467752 chr17:38218738 THRA -0.46 -6.05 -0.35 4.9e-9 Myeloid white cell count; CESC cis rs12410462 0.581 rs111356515 chr1:227537236 C/G cg10327440 chr1:227177885 CDC42BPA -0.68 -5.62 -0.33 4.84e-8 Major depressive disorder; CESC cis rs13082711 0.554 rs73055724 chr3:27380397 T/G cg02860705 chr3:27208620 NA 0.73 8.18 0.45 1.19e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs477692 0.905 rs514963 chr10:131419707 C/T cg05714579 chr10:131428358 MGMT 0.51 7.26 0.41 4.17e-12 Response to temozolomide; CESC cis rs7116495 0.609 rs4245463 chr11:71743213 C/A cg26138937 chr11:71823887 C11orf51 -1.37 -8.21 -0.45 9.44e-15 Severe influenza A (H1N1) infection; CESC cis rs2228479 1.000 rs62052180 chr16:89963289 C/G cg06558623 chr16:89946397 TCF25 1.05 8.66 0.47 4.66e-16 Skin colour saturation; CESC cis rs3733585 0.699 rs7677710 chr4:9969517 T/G cg02734326 chr4:10020555 SLC2A9 -0.39 -5.57 -0.32 6.13e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg09509183 chr1:209979624 IRF6 0.36 5.09 0.3 6.64e-7 Monobrow; CESC cis rs1008375 0.932 rs12500912 chr4:17603318 C/T cg02297831 chr4:17616191 MED28 0.54 6.73 0.38 1.06e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg11764359 chr7:65958608 NA 0.47 5.74 0.33 2.56e-8 Calcium levels; CESC cis rs10216189 0.967 rs4724700 chr7:5526789 A/G cg05318486 chr7:5553423 FBXL18 -0.44 -5.69 -0.33 3.3e-8 Relative hand skill in reading disability; CESC cis rs11625487 0.609 rs45493395 chr14:77976468 T/C cg20045696 chr14:77926864 AHSA1 -0.65 -5.29 -0.31 2.53e-7 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs6028335 0.674 rs66486072 chr20:37647882 G/A cg16355469 chr20:37678765 NA 0.51 5.08 0.3 7.07e-7 Alcohol and nicotine co-dependence; CESC cis rs7771547 0.573 rs566742 chr6:36395668 C/T cg04289385 chr6:36355825 ETV7 0.38 5.5 0.32 8.74e-8 Platelet distribution width; CESC cis rs4642101 0.618 rs9877079 chr3:12821287 A/G cg24848339 chr3:12840334 CAND2 0.39 6.13 0.35 3.24e-9 QRS complex (12-leadsum); CESC cis rs6089584 0.526 rs6089316 chr20:60627552 C/T cg06108461 chr20:60628389 TAF4 -0.61 -8.18 -0.45 1.16e-14 Body mass index; CESC cis rs9911578 1.000 rs8079774 chr17:56908188 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 3.04e-7 Intelligence (multi-trait analysis); CESC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg17376030 chr22:41985996 PMM1 0.58 6.3 0.36 1.21e-9 Vitiligo; CESC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg04369109 chr6:150039330 LATS1 -0.39 -5.27 -0.31 2.82e-7 Lung cancer; CESC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg24562669 chr7:97807699 LMTK2 0.54 7.85 0.43 1.02e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs10489202 0.583 rs203782 chr1:167882386 A/G cg24449463 chr1:168025552 DCAF6 0.43 5.62 0.33 4.83e-8 Schizophrenia; CESC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs17253792 1.000 rs28616134 chr14:56178802 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.73 5.13 0.3 5.7e-7 Putamen volume; CESC cis rs8018808 0.935 rs7146784 chr14:77932111 A/G cg20045696 chr14:77926864 AHSA1 0.43 5.9 0.34 1.13e-8 Myeloid white cell count; CESC cis rs8114671 0.804 rs3803936 chr20:33632775 T/C cg06115741 chr20:33292138 TP53INP2 -0.44 -5.29 -0.31 2.53e-7 Height; CESC cis rs7618501 1.000 rs35261599 chr3:49773236 G/A cg24308560 chr3:49941425 MST1R 0.51 7.06 0.4 1.47e-11 Intelligence (multi-trait analysis); CESC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.64 8.51 0.46 1.28e-15 Total body bone mineral density; CESC cis rs2637266 1.000 rs2395385 chr10:78341125 G/A cg18941641 chr10:78392320 NA 0.41 7.87 0.44 8.88e-14 Pulmonary function; CESC trans rs9650657 0.645 rs4841407 chr8:10516185 G/A cg15556689 chr8:8085844 FLJ10661 -0.5 -6.45 -0.37 5.33e-10 Neuroticism; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14549777 chr3:12599374 MKRN2 -0.47 -6.4 -0.37 7.16e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs863345 0.933 rs12041380 chr1:158482138 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -5.87 -0.34 1.28e-8 Pneumococcal bacteremia; CESC cis rs829883 0.659 rs11109517 chr12:98921574 A/C cg25150519 chr12:98850993 NA 0.6 7.58 0.42 5.9e-13 Colorectal adenoma (advanced); CESC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg24642844 chr7:1081250 C7orf50 -0.81 -9.86 -0.52 9.58e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs116095464 0.614 rs28736753 chr5:274081 G/A cg00938859 chr5:1591904 SDHAP3 0.64 6.78 0.38 7.61e-11 Breast cancer; CESC cis rs2479724 0.905 rs2274578 chr6:41888827 C/G cg08135965 chr6:41755394 TOMM6 0.43 5.92 0.34 9.98e-9 Menarche (age at onset); CESC cis rs9300255 0.550 rs10772997 chr12:123719880 C/A cg05973401 chr12:123451056 ABCB9 0.45 5.51 0.32 8.49e-8 Neutrophil percentage of white cells; CESC cis rs3741151 0.773 rs73542967 chr11:73123512 C/T cg17517138 chr11:73019481 ARHGEF17 0.94 6.86 0.39 4.87e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg25405998 chr7:65216604 CCT6P1 0.46 5.28 0.31 2.68e-7 Aortic root size; CESC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.95 10.43 0.54 1.45e-21 Mean platelet volume; CESC cis rs2354432 0.556 rs2353984 chr1:146813358 C/T cg25205988 chr1:146714368 CHD1L 0.95 8.23 0.45 8.56e-15 Mitochondrial DNA levels; CESC cis rs763121 0.962 rs6001193 chr22:39074737 A/G cg21395723 chr22:39101663 GTPBP1 0.38 5.15 0.3 5.05e-7 Menopause (age at onset); CESC cis rs12136530 0.714 rs34553579 chr1:19779378 A/C cg01832549 chr1:19774989 CAPZB -0.48 -6.95 -0.39 2.8e-11 Lead levels in blood; CESC cis rs12325245 0.536 rs12931124 chr16:58620063 G/A cg01152986 chr16:58549298 SETD6 0.86 5.08 0.3 7.1e-7 Schizophrenia; CESC cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC trans rs17685 0.753 rs6976532 chr7:75681094 A/G cg19862616 chr7:65841803 NCRNA00174 0.88 12.91 0.62 6.43e-30 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2425143 1.000 rs6060578 chr20:34305445 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.15 0.3 5.07e-7 Blood protein levels; CESC cis rs9494145 0.680 rs9402686 chr6:135427817 G/A cg22676075 chr6:135203613 NA 0.46 5.57 0.32 6.41e-8 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CESC cis rs7678296 1.000 rs28385504 chr4:37200490 G/A cg06805348 chr4:37245195 KIAA1239 0.45 5.07 0.3 7.52e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC trans rs9329221 0.905 rs17709397 chr8:10249861 G/A cg15556689 chr8:8085844 FLJ10661 -0.53 -6.13 -0.35 3.26e-9 Neuroticism; CESC cis rs12701220 0.894 rs10263252 chr7:1049949 G/A cg26769984 chr7:1090371 C7orf50 0.54 6.52 0.37 3.5e-10 Bronchopulmonary dysplasia; CESC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg22535103 chr8:58192502 C8orf71 -0.77 -8.68 -0.47 4.09e-16 Developmental language disorder (linguistic errors); CESC cis rs5757673 1 rs5757673 chr22:39837920 T/C cg02038168 chr22:39784481 NA -0.68 -7.86 -0.43 9.97e-14 Post bronchodilator FEV1; CESC cis rs617791 0.530 rs735942 chr11:65749337 A/G cg02427764 chr11:65769310 BANF1;EIF1AD -0.44 -5.2 -0.3 4e-7 Breast cancer; CESC cis rs2243480 1.000 rs34933526 chr7:65383199 A/G cg18252515 chr7:66147081 NA -1.06 -9.79 -0.52 1.67e-19 Diabetic kidney disease; CESC cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg18512352 chr11:47633146 NA -0.51 -7.3 -0.41 3.35e-12 Subjective well-being; CESC cis rs35146811 0.807 rs6465761 chr7:99620277 G/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.32 0.31 2.23e-7 Coronary artery disease; CESC cis rs4718428 0.924 rs6971897 chr7:66412774 T/A cg12165864 chr7:66369176 NA -0.44 -5.17 -0.3 4.73e-7 Corneal structure; CESC cis rs728616 0.558 rs61859215 chr10:82151148 G/A cg05935833 chr10:81318306 SFTPA2 -0.46 -5.71 -0.33 3.08e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.57 0.37 2.71e-10 Breast cancer; CESC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg27170947 chr2:26402098 FAM59B 0.87 9.89 0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs12541635 0.934 rs2029882 chr8:107022894 G/A cg10147462 chr8:107024639 NA 0.41 5.74 0.33 2.63e-8 Age of smoking initiation; CESC cis rs7872515 0.793 rs10820936 chr9:94830974 C/T cg01248375 chr9:94877805 SPTLC1 -0.53 -5.66 -0.33 3.95e-8 Bipolar disorder and schizophrenia; CESC cis rs2732480 0.557 rs2732484 chr12:48737245 A/C cg24011408 chr12:48396354 COL2A1 0.44 5.95 0.34 8.54e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs1348850 0.526 rs7582179 chr2:178370631 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.69 6.38 0.36 7.87e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10504073 0.584 rs62507178 chr8:49938572 A/C cg00325661 chr8:49890786 NA 0.6 8.94 0.48 6.75e-17 Blood metabolite ratios; CESC cis rs12474201 0.928 rs12998753 chr2:46938385 A/G cg06386533 chr2:46925753 SOCS5 0.91 12.52 0.61 1.51e-28 Height; CESC cis rs7524258 0.900 rs1476047 chr1:7312172 C/T cg07173049 chr1:7289937 CAMTA1 0.38 5.94 0.34 9.14e-9 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs6088590 1.000 rs6087632 chr20:33407704 A/C cg08999081 chr20:33150536 PIGU 0.59 8.94 0.48 6.65e-17 Coronary artery disease; CESC cis rs3820928 0.935 rs10203363 chr2:227896976 C/T cg05526886 chr2:227700861 RHBDD1 -0.45 -5.73 -0.33 2.7e-8 Pulmonary function; CESC cis rs902774 0.554 rs4919749 chr12:53358034 C/T cg16329197 chr12:53359506 NA -0.62 -8.88 -0.48 1.06e-16 Prostate cancer; CESC cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg20307385 chr11:47447363 PSMC3 -0.63 -7.61 -0.42 4.69e-13 Subjective well-being; CESC cis rs344364 0.511 rs12599337 chr16:1946751 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.52 5.92 0.34 1.01e-8 Glomerular filtration rate in chronic kidney disease; CESC cis rs3809566 1.000 rs10851721 chr15:63332383 T/C cg05507819 chr15:63340323 TPM1 0.51 6.16 0.35 2.66e-9 Platelet count; CESC cis rs965469 0.857 rs1922990 chr20:3252348 G/A cg25506879 chr20:3388711 C20orf194 -0.49 -5.36 -0.31 1.8e-7 IFN-related cytopenia; CESC cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg04013166 chr16:89971882 TCF25 0.7 7.24 0.41 5.01e-12 Skin colour saturation; CESC cis rs9457247 1.000 rs397713 chr6:167386714 G/A cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC cis rs7089973 0.668 rs7898347 chr10:116644324 G/A cg25233709 chr10:116636983 FAM160B1 0.41 6.6 0.38 2.28e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25846339 chr11:85359022 TMEM126A 0.49 6.4 0.37 7.03e-10 Systemic lupus erythematosus; CESC cis rs59918340 0.764 rs2304282 chr8:142229543 A/G cg16341495 chr8:142228727 SLC45A4 -0.42 -5.07 -0.3 7.6e-7 Immature fraction of reticulocytes; CESC trans rs765547 0.871 rs1372344 chr8:19852939 A/T cg12649343 chr22:47023005 GRAMD4 -0.3 -6.12 -0.35 3.27e-9 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg06074448 chr4:187884817 NA -0.34 -5.18 -0.3 4.31e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.840 rs854144 chr6:146360880 G/T cg23711669 chr6:146136114 FBXO30 -0.56 -7.37 -0.41 2.15e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19652678 chr17:73975160 ACOX1;C17orf106 0.59 6.79 0.38 7.15e-11 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs6460942 0.908 rs7781919 chr7:12235351 T/C cg06484146 chr7:12443880 VWDE -0.46 -5.19 -0.3 4.09e-7 Coronary artery disease; CESC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg26314531 chr2:26401878 FAM59B -0.6 -6.94 -0.39 3.01e-11 Gut microbiome composition (summer); CESC cis rs73206853 0.764 rs28362526 chr12:110561779 C/A cg12870014 chr12:110450643 ANKRD13A 0.64 5.42 0.32 1.36e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs963731 0.649 rs2060989 chr2:39293530 G/A cg04010122 chr2:39346883 SOS1 -0.74 -5.88 -0.34 1.23e-8 Corticobasal degeneration; CESC cis rs933688 0.938 rs7705465 chr5:90680949 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 12.36 0.6 5.17e-28 Smoking behavior; CESC cis rs9611565 0.765 rs132921 chr22:41812044 G/A cg17376030 chr22:41985996 PMM1 -0.52 -5.71 -0.33 3e-8 Vitiligo; CESC cis rs10131894 0.611 rs175002 chr14:75436466 C/G cg08847533 chr14:75593920 NEK9 0.74 12.01 0.59 8.12e-27 Coronary artery disease; CESC cis rs16854884 0.657 rs1867608 chr3:143752938 G/A cg01302019 chr3:143689584 C3orf58 -0.35 -5.42 -0.32 1.33e-7 Economic and political preferences (feminism/equality); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17237962 chr11:57479805 MED19;TMX2 -0.65 -7.19 -0.4 6.46e-12 Gut microbiome composition (summer); CESC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg06074448 chr4:187884817 NA -0.36 -5.17 -0.3 4.63e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg03188948 chr7:1209495 NA 0.51 6.63 0.38 1.83e-10 Longevity;Endometriosis; CESC cis rs7336332 0.598 rs9581852 chr13:28013748 A/G cg01674679 chr13:27998804 GTF3A -0.59 -5.25 -0.31 3.08e-7 Weight; CESC cis rs258892 0.895 rs465388 chr5:72135899 C/T cg21869765 chr5:72125136 TNPO1 0.45 5.72 0.33 2.82e-8 Small cell lung carcinoma; CESC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg15445000 chr17:37608096 MED1 -0.4 -6.31 -0.36 1.2e-9 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16260355 chr10:72575844 SGPL1 0.55 6.35 0.36 9.09e-10 Gut microbiome composition (summer); CESC cis rs1348850 0.574 rs2365617 chr2:178421934 C/A cg22681709 chr2:178499509 PDE11A -0.51 -5.23 -0.31 3.52e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs727505 1.000 rs2286175 chr7:124431032 G/A cg23710748 chr7:124431027 NA -0.49 -7.89 -0.44 7.75e-14 Lewy body disease; CESC cis rs561341 0.882 rs28649357 chr17:30367190 A/G cg19193384 chr17:30244184 NA -0.51 -5.42 -0.32 1.33e-7 Hip circumference adjusted for BMI; CESC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg04166393 chr7:2884313 GNA12 0.58 7.78 0.43 1.6e-13 Height; CESC cis rs1670533 1.000 rs11731320 chr4:1057916 T/A cg04106633 chr4:1044584 NA 0.41 5.19 0.3 4.11e-7 Recombination rate (females); CESC cis rs11722228 0.522 rs2241468 chr4:10113905 G/A cg14348967 chr4:10160060 NA -0.43 -5.33 -0.31 2.11e-7 Gout;Urate levels;Serum uric acid levels; CESC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg12379764 chr21:47803548 PCNT -0.47 -5.51 -0.32 8.65e-8 Testicular germ cell tumor; CESC cis rs1707322 0.964 rs6697830 chr1:46290477 C/A cg03146154 chr1:46216737 IPP 0.72 9.83 0.52 1.2e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4253772 0.872 rs11704508 chr22:46638540 A/G cg18190219 chr22:46762943 CELSR1 -0.61 -5.82 -0.34 1.66e-8 LDL cholesterol;Cholesterol, total; CESC cis rs963731 0.737 rs6544197 chr2:39315388 T/C cg04010122 chr2:39346883 SOS1 -0.74 -5.39 -0.31 1.54e-7 Corticobasal degeneration; CESC cis rs9457247 1.000 rs394522 chr6:167398071 A/C cg25258033 chr6:167368657 RNASET2 0.41 6.17 0.35 2.55e-9 Crohn's disease; CESC cis rs3105593 1.000 rs3131596 chr15:50877575 T/C cg08437265 chr15:50716283 USP8 0.42 5.33 0.31 2.12e-7 QT interval; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg03404566 chr17:6899310 ALOX12 -0.39 -6.53 -0.37 3.34e-10 Tonsillectomy; CESC cis rs73129298 0.551 rs6020166 chr20:48594678 A/G cg25655593 chr20:48599521 SNAI1 0.46 5.15 0.3 5.05e-7 Inflammatory skin disease; CESC cis rs651907 0.535 rs13059470 chr3:101424800 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.47 -6.08 -0.35 4.23e-9 Colorectal cancer; CESC cis rs7937682 0.855 rs7934922 chr11:111500026 T/C cg09085632 chr11:111637200 PPP2R1B -0.99 -15.77 -0.7 5.94e-40 Primary sclerosing cholangitis; CESC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg23708337 chr7:1209742 NA 0.54 5.4 0.31 1.48e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg25036284 chr2:26402008 FAM59B -0.58 -6.62 -0.38 1.98e-10 Gut microbiome composition (summer); CESC cis rs9379850 0.527 rs9393704 chr6:26358775 T/C cg14345882 chr6:26364793 BTN3A2 0.59 6.06 0.35 4.66e-9 Intelligence (multi-trait analysis); CESC cis rs3892630 0.619 rs61062732 chr19:33304717 T/C cg13157960 chr19:33183277 NUDT19 0.55 5.59 0.32 5.67e-8 Red blood cell traits; CESC cis rs1692580 0.870 rs590367 chr1:2162944 C/T cg21194808 chr1:2205498 SKI 0.39 5.45 0.32 1.17e-7 Coronary artery disease; CESC cis rs5769765 0.955 rs5769767 chr22:50276909 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs34779708 0.733 rs4244997 chr10:35547254 T/C cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs7264396 0.512 rs2425072 chr20:34293686 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.51 -0.54 8.09e-22 Total cholesterol levels; CESC cis rs2262909 0.962 rs439574 chr19:22232024 A/C cg11619707 chr19:22235551 ZNF257 -0.3 -5.17 -0.3 4.72e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs9479482 0.967 rs34006533 chr6:150350574 C/A cg03788504 chr6:150331562 NA -0.38 -7.09 -0.4 1.21e-11 Alopecia areata; CESC cis rs7618501 1.000 rs57648519 chr3:49813169 C/A cg24308560 chr3:49941425 MST1R -0.52 -7.04 -0.4 1.63e-11 Intelligence (multi-trait analysis); CESC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.04 -0.56 1.41e-23 Alzheimer's disease; CESC cis rs12893668 0.697 rs67899457 chr14:104060066 A/T cg08213375 chr14:104286397 PPP1R13B 0.35 5.68 0.33 3.57e-8 Reticulocyte count; CESC cis rs8049040 0.586 rs8060176 chr16:71456757 T/C cg08717414 chr16:71523259 ZNF19 -0.44 -5.05 -0.3 8.15e-7 Blood protein levels; CESC cis rs6741892 0.536 rs7590835 chr2:38893950 A/G cg01546378 chr2:38892901 GALM 0.51 7.14 0.4 8.85e-12 5-HTT brain serotonin transporter levels; CESC cis rs9894429 0.546 rs55917554 chr17:79608776 T/C cg21984481 chr17:79567631 NPLOC4 -0.4 -6.02 -0.35 5.7e-9 Eye color traits; CESC cis rs11676348 0.776 rs11690316 chr2:219017462 A/G cg00012203 chr2:219082015 ARPC2 -0.6 -7.65 -0.43 3.64e-13 Ulcerative colitis; CESC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg03709012 chr19:19516395 GATAD2A -0.96 -14.2 -0.66 2.12e-34 Tonsillectomy; CESC cis rs1008375 1.000 rs7694020 chr4:17682597 C/T cg16339924 chr4:17578868 LAP3 0.49 6.22 0.36 1.88e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1832871 0.711 rs9459769 chr6:158666493 T/C cg07165851 chr6:158734300 TULP4 0.6 6.41 0.37 6.66e-10 Height; CESC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 6.72 0.38 1.11e-10 Electroencephalogram traits; CESC trans rs11098499 0.754 rs12513083 chr4:120249612 A/T cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg04733989 chr22:42467013 NAGA 0.83 12.3 0.6 8.24e-28 Schizophrenia; CESC cis rs1552244 0.554 rs13079240 chr3:10047246 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -7.26 -0.41 4.31e-12 Alzheimer's disease; CESC cis rs3820068 0.603 rs7531396 chr1:15969870 G/C cg16988262 chr1:15930761 NA 0.33 5.36 0.31 1.85e-7 Systolic blood pressure; CESC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg11644478 chr21:40555479 PSMG1 -0.81 -11.99 -0.59 9.12e-27 Cognitive function; CESC cis rs2985684 0.894 rs4581611 chr14:50043520 A/T cg04989706 chr14:50066350 PPIL5 -0.45 -5.05 -0.3 8.09e-7 Carotid intima media thickness; CESC cis rs10821556 1 rs10821556 chr9:136942136 C/A cg13495838 chr9:136934004 BRD3 0.45 5.26 0.31 3.04e-7 Mean platelet volume; CESC cis rs939574 1.000 rs2293078 chr2:220100683 C/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.83 7.3 0.41 3.45e-12 Platelet distribution width; CESC cis rs17376456 0.825 rs10053405 chr5:93275403 A/G cg21475434 chr5:93447410 FAM172A -0.67 -5.3 -0.31 2.4e-7 Diabetic retinopathy; CESC cis rs662064 0.748 rs2506896 chr1:10603716 T/C cg20482658 chr1:10539492 PEX14 0.43 8.91 0.48 8.55e-17 Asthma; CESC cis rs10779751 1.000 rs4845982 chr1:11271576 T/C cg08854313 chr1:11322531 MTOR 0.78 10.56 0.54 5.31e-22 Body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04018571 chr2:96874059 STARD7 -0.41 -6.46 -0.37 4.85e-10 Gambling; CESC trans rs61931739 0.511 rs2035659 chr12:33826241 T/C cg26384229 chr12:38710491 ALG10B 0.45 6.25 0.36 1.61e-9 Morning vs. evening chronotype; CESC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg10578991 chr7:12443926 VWDE -0.45 -5.09 -0.3 6.83e-7 Coronary artery disease; CESC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.53 7.3 0.41 3.37e-12 Menopause (age at onset); CESC cis rs61996546 0.622 rs1426219 chr15:26855799 C/T cg14859324 chr15:26874363 GABRB3 -0.37 -5.06 -0.3 7.97e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs2404602 0.647 rs3812909 chr15:77176200 A/T cg23625390 chr15:77176239 SCAPER -0.45 -6.35 -0.36 9.29e-10 Blood metabolite levels; CESC cis rs861020 0.677 rs12723578 chr1:210032392 G/A cg05527609 chr1:210001259 C1orf107 -1.04 -12.0 -0.59 8.74e-27 Orofacial clefts; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06006530 chr2:242608094 ATG4B 0.44 6.07 0.35 4.38e-9 Fibrinogen levels; CESC cis rs863345 0.604 rs11265024 chr1:158513255 A/G cg12129480 chr1:158549410 OR10X1 -0.35 -6.95 -0.39 2.92e-11 Pneumococcal bacteremia; CESC cis rs6815814 0.851 rs73235002 chr4:38769018 A/G cg02016764 chr4:38805732 TLR1 -0.67 -7.46 -0.42 1.21e-12 Breast cancer; CESC cis rs8031584 0.918 rs11639169 chr15:31255438 C/T cg14829155 chr15:31115871 NA -0.66 -8.51 -0.46 1.27e-15 Huntington's disease progression; CESC trans rs4824093 0.535 rs73443931 chr22:50291603 G/A cg09872104 chr7:134855509 C7orf49 -0.94 -6.17 -0.35 2.52e-9 Amyotrophic lateral sclerosis (sporadic); CESC cis rs13385 0.769 rs17208094 chr5:139597580 T/G cg26211634 chr5:139558579 C5orf32 0.47 5.04 0.3 8.72e-7 Atrial fibrillation; CESC cis rs763121 0.853 rs138709 chr22:39139216 C/G cg21395723 chr22:39101663 GTPBP1 0.47 6.51 0.37 3.84e-10 Menopause (age at onset); CESC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.58 0.37 2.49e-10 Prudent dietary pattern; CESC cis rs11190604 1.000 rs10883500 chr10:102238324 T/G cg07080220 chr10:102295463 HIF1AN 0.56 5.59 0.32 5.61e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg14393609 chr7:65229607 NA 0.51 6.75 0.38 9.12e-11 Aortic root size; CESC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg09263875 chr16:632152 PIGQ 0.67 11.39 0.57 1e-24 Height; CESC cis rs12464559 0.579 rs1523181 chr2:152679462 T/C cg01189475 chr2:152685088 ARL5A 0.66 5.81 0.34 1.74e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs870825 0.655 rs7675046 chr4:185652201 G/A cg04058563 chr4:185651563 MLF1IP -0.6 -6.93 -0.39 3.28e-11 Blood protein levels; CESC cis rs27434 0.605 rs152468 chr5:96167536 T/C cg16492584 chr5:96139282 ERAP1 -0.53 -6.42 -0.37 6.14e-10 Ankylosing spondylitis; CESC cis rs8016982 0.657 rs11625861 chr14:81735001 C/T cg01989461 chr14:81687754 GTF2A1 -0.65 -9.73 -0.51 2.58e-19 Schizophrenia; CESC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg20644253 chr19:19431407 KIAA0892;SF4 0.61 7.68 0.43 3.13e-13 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24631870 chr3:142297635 ATR 0.57 6.07 0.35 4.48e-9 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs12173015 chr5:269967 A/C cg22496380 chr5:211416 CCDC127 0.54 5.95 0.34 8.26e-9 Breast cancer; CESC trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg03929089 chr4:120376271 NA -0.78 -11.69 -0.58 1e-25 Coronary artery disease; CESC cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 5.35 0.31 1.91e-7 Tonsillectomy; CESC cis rs7116495 0.609 rs4477459 chr11:71720616 T/C cg26138937 chr11:71823887 C11orf51 -1.31 -8.57 -0.47 8.98e-16 Severe influenza A (H1N1) infection; CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg16132339 chr22:24313637 DDTL;DDT 0.38 5.78 0.33 2.08e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6087771 0.642 rs6060411 chr20:30222139 T/C cg13852791 chr20:30311386 BCL2L1 0.67 7.77 0.43 1.7e-13 Subcortical brain region volumes;Putamen volume; CESC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg25072359 chr17:41440525 NA 0.48 6.47 0.37 4.76e-10 Menopause (age at onset); CESC cis rs11235843 0.613 rs71464090 chr11:73596791 T/G cg18195628 chr11:73498948 MRPL48 0.56 6.07 0.35 4.34e-9 Hand grip strength; CESC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg07701084 chr6:150067640 NUP43 0.45 6.38 0.36 8e-10 Lung cancer; CESC cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg02297831 chr4:17616191 MED28 0.5 6.07 0.35 4.52e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9815354 0.680 rs61646756 chr3:42029352 A/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs4642101 0.793 rs3889513 chr3:12844070 G/A cg05775895 chr3:12838266 CAND2 0.39 5.78 0.33 2.1e-8 QRS complex (12-leadsum); CESC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 10.81 0.55 8.61e-23 Platelet count; CESC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg18230493 chr5:56204884 C5orf35 -0.75 -8.98 -0.48 5.21e-17 Initial pursuit acceleration; CESC cis rs57502260 0.680 rs7104806 chr11:68222188 C/T cg20283391 chr11:68216788 NA -0.66 -5.76 -0.33 2.35e-8 Total body bone mineral density (age 45-60); CESC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg10074409 chr1:209979377 IRF6 0.4 5.32 0.31 2.16e-7 Cleft lip with or without cleft palate; CESC cis rs6598955 0.724 rs12068388 chr1:26621596 G/A cg00852783 chr1:26633632 UBXN11 0.44 6.41 0.37 6.69e-10 Obesity-related traits; CESC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg18876405 chr7:65276391 NA -0.55 -6.11 -0.35 3.49e-9 Aortic root size; CESC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg18904891 chr8:8559673 CLDN23 0.7 7.82 0.43 1.26e-13 Obesity-related traits; CESC cis rs3105593 1.000 rs2115671 chr15:50956432 G/C cg08437265 chr15:50716283 USP8 0.46 6.04 0.35 5.08e-9 QT interval; CESC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg10150615 chr22:24372951 LOC391322 -0.59 -8.05 -0.44 2.87e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22185043 chr18:12947723 SEH1L 0.43 5.84 0.34 1.53e-8 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg21138405 chr5:131827807 IRF1 0.54 9.24 0.49 8.12e-18 Asthma (sex interaction); CESC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg14773178 chr5:1868261 NA 0.32 5.71 0.33 2.98e-8 Cardiovascular disease risk factors; CESC cis rs7116495 0.737 rs670802 chr11:71799668 A/C cg10381502 chr11:71823885 C11orf51 -0.65 -5.24 -0.31 3.2e-7 Severe influenza A (H1N1) infection; CESC cis rs2204008 0.546 rs11519978 chr12:37998170 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.63 0.38 1.87e-10 Bladder cancer; CESC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.78 0.59 4.93e-26 Alzheimer's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22052955 chr12:53625898 RARG -0.44 -6.26 -0.36 1.53e-9 Gambling; CESC cis rs6460942 1.000 rs62448565 chr7:12400458 G/A cg06484146 chr7:12443880 VWDE -0.69 -7.94 -0.44 5.59e-14 Coronary artery disease; CESC cis rs6504950 0.566 rs7226272 chr17:53046447 G/A cg19360675 chr17:53046073 COX11;STXBP4 0.43 5.49 0.32 9.53e-8 Breast cancer; CESC cis rs7666738 0.830 rs13133355 chr4:98919415 A/G cg05340658 chr4:99064831 C4orf37 0.76 11.36 0.57 1.29e-24 Colonoscopy-negative controls vs population controls; CESC cis rs2625529 0.652 rs7497104 chr15:72154000 C/T cg16672083 chr15:72433130 SENP8 -0.47 -7.09 -0.4 1.25e-11 Red blood cell count; CESC cis rs67311347 1.000 rs7633809 chr3:40517737 A/G cg24209194 chr3:40518798 ZNF619 -0.54 -7.02 -0.4 1.81e-11 Renal cell carcinoma; CESC trans rs10411161 0.702 rs8100716 chr19:52384061 T/C cg22319618 chr22:45562946 NUP50 -0.71 -6.88 -0.39 4.2e-11 Breast cancer; CESC cis rs524281 0.861 rs11227403 chr11:65858428 T/C cg14036092 chr11:66035641 RAB1B -0.62 -6.29 -0.36 1.27e-9 Electroencephalogram traits; CESC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg01341218 chr17:43662625 NA -0.8 -9.59 -0.51 6.96e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2880765 0.835 rs7163958 chr15:86045215 G/A cg10818794 chr15:86012489 AKAP13 -0.34 -5.24 -0.31 3.28e-7 Coronary artery disease; CESC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg18032046 chr6:28092343 ZSCAN16 0.57 6.58 0.37 2.47e-10 Depression; CESC cis rs9814567 0.896 rs11915964 chr3:134348930 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.43 5.87 0.34 1.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -10.26 -0.53 5.12e-21 Extrinsic epigenetic age acceleration; CESC cis rs7537660 1.000 rs10888257 chr1:248004877 C/T cg12080717 chr1:248004886 OR11L1 -0.46 -5.62 -0.33 4.74e-8 Platelet distribution width; CESC cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.52 0.32 7.98e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4780401 0.546 rs3743588 chr16:11836508 G/A cg01061890 chr16:11836724 TXNDC11 0.66 8.31 0.45 4.99e-15 Rheumatoid arthritis; CESC cis rs734999 0.588 rs3748817 chr1:2525665 T/C cg20673091 chr1:2541236 MMEL1 0.44 7.49 0.42 1.01e-12 Ulcerative colitis; CESC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg18876405 chr7:65276391 NA 0.5 6.84 0.39 5.47e-11 Aortic root size; CESC cis rs1003719 0.788 rs4411798 chr21:38453183 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.56 7.43 0.42 1.51e-12 Eye color traits; CESC cis rs7116495 1.000 rs17161966 chr11:71815308 T/C cg10381502 chr11:71823885 C11orf51 0.66 5.35 0.31 1.93e-7 Severe influenza A (H1N1) infection; CESC cis rs1153858 1.000 rs12593370 chr15:45617417 C/T cg21132104 chr15:45694354 SPATA5L1 0.82 10.84 0.55 6.43e-23 Homoarginine levels; CESC cis rs9309473 0.607 rs6546826 chr2:73599808 A/G cg20560298 chr2:73613845 ALMS1 0.52 7.22 0.41 5.45e-12 Metabolite levels; CESC cis rs67311347 1.000 rs11714912 chr3:40494065 A/G cg01475735 chr3:40494733 NA 0.4 5.16 0.3 4.81e-7 Renal cell carcinoma; CESC cis rs1552244 0.554 rs3732965 chr3:10048760 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.61 7.88 0.44 8.63e-14 Alzheimer's disease; CESC cis rs1559088 0.948 rs10410778 chr19:33592301 C/A cg27124370 chr19:33622961 WDR88 0.45 6.0 0.35 6.49e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7072216 0.763 rs2274246 chr10:100175060 C/T cg26618903 chr10:100175079 PYROXD2 -0.38 -5.85 -0.34 1.41e-8 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25949093 chr19:5142198 KDM4B -0.55 -6.67 -0.38 1.48e-10 Gut microbiome composition (summer); CESC cis rs734999 0.505 rs10797437 chr1:2539006 T/C cg20673091 chr1:2541236 MMEL1 0.45 7.79 0.43 1.5e-13 Ulcerative colitis; CESC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg02935154 chr7:12443704 VWDE -0.58 -7.77 -0.43 1.76e-13 Coronary artery disease; CESC cis rs8072100 0.840 rs12453233 chr17:45454570 C/T cg08085267 chr17:45401833 C17orf57 -0.54 -7.22 -0.41 5.38e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.62 0.33 4.71e-8 Bipolar disorder; CESC trans rs748404 0.578 rs2278856 chr15:43631356 G/A cg24053811 chr14:70265306 SLC10A1 0.42 6.08 0.35 4.18e-9 Lung cancer; CESC cis rs2549003 0.934 rs2549006 chr5:131827065 A/G cg21138405 chr5:131827807 IRF1 -0.63 -10.68 -0.55 2.24e-22 Asthma (sex interaction); CESC cis rs938554 0.694 rs4697700 chr4:9945792 C/G cg11266682 chr4:10021025 SLC2A9 0.39 5.29 0.31 2.59e-7 Blood metabolite levels; CESC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg20151795 chr6:28129481 ZNF389 0.46 5.96 0.34 8.01e-9 Depression; CESC cis rs7824557 0.527 rs2572447 chr8:11239510 G/A cg21775007 chr8:11205619 TDH -0.52 -7.78 -0.43 1.65e-13 Retinal vascular caliber; CESC cis rs3105593 1.000 rs3101852 chr15:50848370 C/T cg08437265 chr15:50716283 USP8 -0.42 -5.53 -0.32 7.82e-8 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17533455 chr5:130599827 CDC42SE2 0.67 8.13 0.45 1.69e-14 Gut microbiome composition (summer); CESC cis rs3781458 0.842 rs897300 chr10:126320902 A/G cg20435097 chr10:126320824 FAM53B 0.28 5.41 0.32 1.43e-7 Male-pattern baldness; CESC cis rs7772486 0.658 rs4895683 chr6:146113654 T/A cg05347473 chr6:146136440 FBXO30 -0.53 -7.0 -0.39 2.13e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg06028605 chr16:24865363 SLC5A11 0.55 8.13 0.45 1.62e-14 Intelligence (multi-trait analysis); CESC trans rs11239930 0.517 rs590286 chr1:146545604 A/C cg23400715 chr22:48900624 FAM19A5 -0.35 -6.07 -0.35 4.4e-9 AIDS progression; CESC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg17221315 chr6:27791827 HIST1H4J 0.46 6.09 0.35 3.98e-9 Cardiac Troponin-T levels; CESC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg22920501 chr2:26401640 FAM59B 0.64 7.97 0.44 4.77e-14 Gut microbiome composition (summer); CESC cis rs4268898 0.662 rs2891382 chr2:24511491 C/G cg08917208 chr2:24149416 ATAD2B 0.51 5.23 0.31 3.43e-7 Asthma; CESC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.54 -0.32 7.28e-8 Lung cancer; CESC cis rs4319547 0.695 rs113841747 chr12:122886088 G/T cg05707623 chr12:122985044 ZCCHC8 0.54 6.14 0.35 3.02e-9 Body mass index; CESC cis rs2073300 0.609 rs8183135 chr20:23384284 C/T cg12062639 chr20:23401060 NAPB 1.07 8.85 0.48 1.29e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs910316 0.789 rs175457 chr14:75584507 C/T cg16144293 chr14:75469539 EIF2B2 0.41 5.38 0.31 1.61e-7 Height; CESC cis rs9929218 1.000 rs8045022 chr16:68807087 T/C cg02972257 chr16:68554789 NA 0.43 5.12 0.3 5.89e-7 Colorectal cancer; CESC cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.94e-9 Extrinsic epigenetic age acceleration; CESC cis rs2836633 0.929 rs2836610 chr21:40044502 C/T cg05519781 chr21:40033154 ERG 0.73 11.68 0.58 1.02e-25 Coronary artery disease; CESC cis rs6088580 0.634 rs6059875 chr20:33086090 T/G cg08999081 chr20:33150536 PIGU 0.65 11.45 0.58 6.19e-25 Glomerular filtration rate (creatinine); CESC cis rs7246657 0.943 rs4417644 chr19:37852472 A/G cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg17211192 chr8:82754475 SNX16 -0.56 -7.13 -0.4 9.36e-12 Diastolic blood pressure; CESC cis rs9814567 1.000 rs7637227 chr3:134244155 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.08 -0.35 4.19e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg00129232 chr17:37814104 STARD3 0.57 7.67 0.43 3.29e-13 Glomerular filtration rate (creatinine); CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.51 0.37 3.79e-10 Electroencephalogram traits; CESC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC trans rs208515 0.525 rs12215007 chr6:66671008 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -11.47 -0.58 5.22e-25 Exhaled nitric oxide levels; CESC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.73 0.38 1.04e-10 Bipolar disorder; CESC cis rs853679 0.882 rs9461432 chr6:28086883 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.81 7.45 0.42 1.31e-12 Depression; CESC cis rs7927592 0.956 rs12277225 chr11:68340967 T/C cg16797656 chr11:68205561 LRP5 0.39 5.37 0.31 1.72e-7 Total body bone mineral density; CESC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg04166393 chr7:2884313 GNA12 0.61 7.85 0.43 1.03e-13 Height; CESC trans rs4335177 0.963 rs969650 chr9:109378080 T/C cg12580783 chr12:49362475 WNT10B -0.34 -6.55 -0.37 2.96e-10 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs10088262 0.629 rs7833650 chr8:124822969 C/T cg02993010 chr8:124780839 FAM91A1 -0.66 -8.05 -0.44 2.76e-14 Pancreatic cancer; CESC cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg15556689 chr8:8085844 FLJ10661 -0.59 -7.82 -0.43 1.28e-13 Mood instability; CESC cis rs921968 0.565 rs13412324 chr2:219620521 T/C cg02176678 chr2:219576539 TTLL4 -0.44 -7.67 -0.43 3.29e-13 Mean corpuscular hemoglobin concentration; CESC cis rs6430585 0.646 rs12468768 chr2:136494985 C/T cg07169764 chr2:136633963 MCM6 1.35 15.39 0.69 1.31e-38 Corneal structure; CESC cis rs6500395 1.000 rs3826174 chr16:48591012 T/C cg04672837 chr16:48644449 N4BP1 0.5 6.23 0.36 1.78e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs10435719 0.899 rs9329251 chr8:11793606 G/A cg15556689 chr8:8085844 FLJ10661 0.52 6.39 0.37 7.33e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs8070740 0.898 rs9896735 chr17:5325808 G/T cg25236894 chr17:5323110 RPAIN;NUP88 -0.51 -6.56 -0.37 2.75e-10 Menopause (age at onset); CESC cis rs9905704 0.633 rs4793588 chr17:56471051 G/T cg12560992 chr17:57184187 TRIM37 -0.62 -5.72 -0.33 2.94e-8 Testicular germ cell tumor; CESC cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg22535103 chr8:58192502 C8orf71 -0.92 -11.29 -0.57 2.15e-24 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg08499158 chr17:42289980 UBTF 0.43 5.21 0.3 3.86e-7 Total body bone mineral density; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15537487 chr10:1043368 GTPBP4 -0.47 -6.48 -0.37 4.41e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17105206 chr16:67211972 KIAA0895L 0.61 7.24 0.41 4.97e-12 Gut microbiome composition (summer); CESC trans rs875971 1.000 rs6460296 chr7:65895139 C/T cg26939375 chr7:64535504 NA 0.47 6.09 0.35 4.06e-9 Aortic root size; CESC cis rs2710642 0.925 rs72807578 chr2:63008044 G/A cg17519650 chr2:63277830 OTX1 -0.53 -6.45 -0.37 5.27e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs7918232 0.825 rs4749233 chr10:27467967 G/A cg14240646 chr10:27532245 ACBD5 -0.67 -6.57 -0.37 2.65e-10 Breast cancer; CESC cis rs12464483 0.591 rs4952170 chr2:30885429 G/A cg17749961 chr2:30669863 LCLAT1 0.7 7.16 0.4 8.11e-12 Pre-treatment pain in head and neck squamous cell carcinoma; CESC cis rs6448317 0.954 rs13139649 chr4:24922007 C/A cg21108841 chr4:24914750 CCDC149 -0.56 -6.68 -0.38 1.36e-10 Heschl's gyrus morphology; CESC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.18e-7 Aortic root size; CESC cis rs61931739 0.500 rs11053242 chr12:34511625 A/G cg06521331 chr12:34319734 NA -0.37 -5.09 -0.3 6.85e-7 Morning vs. evening chronotype; CESC cis rs11098499 0.604 rs12642411 chr4:120580525 T/C cg24375607 chr4:120327624 NA 0.42 5.08 0.3 7.07e-7 Corneal astigmatism; CESC trans rs8073060 0.586 rs7212488 chr17:33993476 A/T cg19694781 chr19:47549865 TMEM160 -0.75 -7.46 -0.42 1.21e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7940866 0.903 rs10791112 chr11:130870215 A/C cg12179176 chr11:130786555 SNX19 -0.56 -7.93 -0.44 6.2e-14 Schizophrenia; CESC cis rs9457247 1.000 rs422562 chr6:167406318 A/G cg25258033 chr6:167368657 RNASET2 0.41 6.14 0.35 3.06e-9 Crohn's disease; CESC cis rs8077577 1.000 rs7207276 chr17:18065737 G/C cg16794390 chr17:18148240 FLII 0.41 5.65 0.33 4.04e-8 Obesity-related traits; CESC trans rs6499129 0.702 rs6499119 chr16:67277666 T/A cg17013778 chr10:135130084 NA -0.72 -6.28 -0.36 1.37e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg24562669 chr7:97807699 LMTK2 0.49 7.17 0.4 7.48e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs2050392 0.517 rs603072 chr10:30755778 C/T cg25182066 chr10:30743637 MAP3K8 0.5 7.13 0.4 9.74e-12 Inflammatory bowel disease; CESC trans rs1945213 0.694 rs10895985 chr11:55831595 T/C cg03929089 chr4:120376271 NA 0.76 7.23 0.41 5.06e-12 Acute lymphoblastic leukemia (childhood); CESC trans rs7937682 0.924 rs10891283 chr11:111527672 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.08 0.35 4.15e-9 Primary sclerosing cholangitis; CESC cis rs7845219 0.544 rs4735331 chr8:95917958 C/T cg16049864 chr8:95962084 TP53INP1 -0.5 -7.48 -0.42 1.06e-12 Type 2 diabetes; CESC cis rs7017914 0.934 rs78923624 chr8:71677839 G/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.22 -0.31 3.65e-7 Bone mineral density; CESC cis rs854765 0.547 rs7224047 chr17:17932931 G/A cg16928487 chr17:17741425 SREBF1 -0.53 -8.99 -0.48 4.71e-17 Total body bone mineral density; CESC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.69 0.38 1.29e-10 Bipolar disorder; CESC cis rs909674 0.514 rs7423 chr22:39781429 C/T cg24399712 chr22:39784796 NA -0.73 -10.58 -0.55 4.55e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs372883 0.563 rs1153293 chr21:30691325 C/T cg24692254 chr21:30365293 RNF160 0.59 7.28 0.41 3.75e-12 Pancreatic cancer; CESC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg17971929 chr21:40555470 PSMG1 1.06 15.93 0.7 1.54e-40 Cognitive function; CESC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg18190219 chr22:46762943 CELSR1 -0.56 -6.44 -0.37 5.69e-10 LDL cholesterol;Cholesterol, total; CESC cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.4 0.32 1.46e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg26338869 chr17:61819248 STRADA 0.67 8.66 0.47 4.55e-16 Prudent dietary pattern; CESC cis rs9911578 1.000 rs9907499 chr17:56949044 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.96 -0.39 2.6e-11 Intelligence (multi-trait analysis); CESC cis rs798554 0.600 rs2679259 chr7:2885322 C/G cg04166393 chr7:2884313 GNA12 0.42 5.58 0.32 6.06e-8 Height; CESC cis rs8017423 0.967 rs8009493 chr14:90690083 G/C cg14092571 chr14:90743983 NA -0.56 -8.24 -0.45 7.77e-15 Mortality in heart failure; CESC cis rs1707322 1.000 rs34446427 chr1:46417655 A/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg23978390 chr7:1156363 C7orf50 0.63 8.77 0.47 2.17e-16 Longevity;Endometriosis; CESC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg04369109 chr6:150039330 LATS1 -0.42 -5.95 -0.34 8.52e-9 Lung cancer; CESC cis rs367943 0.608 rs6859352 chr5:113007384 A/C cg12552261 chr5:112820674 MCC 0.44 5.36 0.31 1.85e-7 Type 2 diabetes; CESC trans rs35110281 0.715 rs969060 chr21:45080852 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 6.65 0.38 1.71e-10 Mean corpuscular volume; CESC cis rs2180341 0.597 rs3798859 chr6:127663116 C/T cg27446573 chr6:127587934 RNF146 0.63 8.53 0.46 1.18e-15 Breast cancer; CESC cis rs5769707 0.706 rs2071903 chr22:50034517 G/A cg20744362 chr22:50050164 C22orf34 0.37 5.12 0.3 6.01e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg02524346 chr8:600233 NA 0.85 6.05 0.35 5.02e-9 IgG glycosylation; CESC cis rs295140 0.506 rs4673854 chr2:201134736 G/A cg23649088 chr2:200775458 C2orf69 -0.39 -5.12 -0.3 5.86e-7 QT interval; CESC cis rs916888 0.773 rs199457 chr17:44795469 C/T cg15921436 chr17:44337874 NA 0.75 7.9 0.44 7.36e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12165864 chr7:66369176 NA 0.5 6.61 0.38 2.1e-10 Fibrinogen levels; CESC cis rs1538970 0.816 rs61788356 chr1:46006675 C/T cg05343316 chr1:45956843 TESK2 0.87 11.58 0.58 2.38e-25 Platelet count; CESC cis rs9875589 0.509 rs9836573 chr3:14065239 G/A cg19554555 chr3:13937349 NA -0.44 -5.6 -0.33 5.43e-8 Ovarian reserve; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04454272 chr22:31795531 DRG1 0.6 6.65 0.38 1.63e-10 Gut microbiome composition (summer); CESC cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg26597838 chr10:835615 NA 0.82 8.72 0.47 3.1e-16 Eosinophil percentage of granulocytes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08862778 chr1:11322643 MTOR -0.47 -7.16 -0.4 7.72e-12 Gambling; CESC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg26338869 chr17:61819248 STRADA 0.67 8.72 0.47 3.12e-16 Prudent dietary pattern; CESC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg21984481 chr17:79567631 NPLOC4 -0.35 -5.34 -0.31 1.97e-7 Eye color traits; CESC cis rs8111998 0.826 rs10418805 chr19:22765991 A/G cg19914732 chr19:22715077 NA -0.4 -5.27 -0.31 2.88e-7 Corneal structure; CESC cis rs1497406 0.773 rs7538833 chr1:16504381 T/C cg20430773 chr1:16534157 ARHGEF19 0.33 5.33 0.31 2.11e-7 Gamma gluatamyl transferase levels;Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs8029989 0.869 rs8039162 chr15:38740829 A/G cg24306142 chr1:17231793 NA -0.44 -6.1 -0.35 3.77e-9 Psychosis (atypical); CESC cis rs6456156 0.586 rs9459862 chr6:167487011 A/G cg07741184 chr6:167504864 NA -0.34 -5.99 -0.35 6.88e-9 Primary biliary cholangitis; CESC cis rs7149337 0.869 rs10137445 chr14:51694416 G/A cg23942311 chr14:51606299 NA 0.45 7.36 0.41 2.33e-12 Cancer; CESC cis rs7224668 0.647 rs2292184 chr17:79244802 T/C cg05632623 chr17:78450055 NPTX1 -0.29 -5.06 -0.3 7.79e-7 IgG glycosylation; CESC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg13206674 chr6:150067644 NUP43 0.45 6.53 0.37 3.37e-10 Lung cancer; CESC cis rs6893300 0.785 rs7704520 chr5:179191054 G/A cg14593053 chr5:179126677 CANX -0.49 -5.85 -0.34 1.43e-8 Resting heart rate; CESC cis rs56309584 0.673 rs11078735 chr17:8116861 C/A cg06726167 chr17:8076949 TMEM107 -0.5 -5.16 -0.3 4.88e-7 Initial pursuit acceleration; CESC cis rs4662945 0.525 rs28819474 chr2:130264623 T/C cg05903289 chr2:130345205 NA -0.41 -6.36 -0.36 8.81e-10 Response to cytidine analogues (gemcitabine); CESC cis rs1707322 0.721 rs6699418 chr1:46100181 G/A cg05343316 chr1:45956843 TESK2 0.5 6.34 0.36 9.93e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23214207 chr17:18476059 NA -0.46 -6.22 -0.36 1.9e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1707322 1.000 rs785510 chr1:46528618 T/C cg03146154 chr1:46216737 IPP -0.74 -9.67 -0.51 3.81e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9790314 1.000 rs336583 chr3:161081981 A/T cg04691961 chr3:161091175 C3orf57 0.43 5.44 0.32 1.22e-7 Morning vs. evening chronotype; CESC cis rs7786877 0.626 rs11770389 chr7:100221218 T/G cg16850897 chr7:100343110 ZAN -0.62 -6.54 -0.37 3.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6964587 0.610 rs6465338 chr7:91450624 T/C cg17063962 chr7:91808500 NA 0.42 5.77 0.33 2.23e-8 Breast cancer; CESC cis rs2455799 0.613 rs4684261 chr3:15796505 G/A cg09340198 chr3:15902540 ANKRD28 -0.33 -5.16 -0.3 4.94e-7 Mean platelet volume; CESC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg04871131 chr7:94954202 PON1 -0.41 -5.72 -0.33 2.92e-8 Paraoxonase activity; CESC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg00612595 chr21:47717864 NA -0.41 -5.62 -0.33 4.93e-8 Testicular germ cell tumor; CESC cis rs11203032 0.710 rs10887923 chr10:90930404 C/T cg16672925 chr10:90967113 CH25H 0.7 6.65 0.38 1.62e-10 Heart failure; CESC cis rs2952156 0.959 rs2941503 chr17:37828745 A/G cg20243544 chr17:37824526 PNMT 0.64 7.93 0.44 6.26e-14 Asthma; CESC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg05564831 chr3:52568323 NT5DC2 0.44 6.68 0.38 1.43e-10 Bipolar disorder; CESC trans rs1606974 0.737 rs4971757 chr2:51934748 G/A cg00084019 chr7:176739 NA 0.47 6.05 0.35 4.98e-9 Educational attainment (years of education);Educational attainment; CESC cis rs2425143 1.000 rs6058304 chr20:34299851 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -7.35 -0.41 2.49e-12 Blood protein levels; CESC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg23708337 chr7:1209742 NA 0.55 5.42 0.32 1.33e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9287719 0.967 rs9287720 chr2:10752664 C/T cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01026192 chr7:2763915 NA 0.47 6.36 0.36 8.72e-10 Fibrinogen levels; CESC cis rs4253772 0.550 rs55926596 chr22:46682955 C/T cg18190219 chr22:46762943 CELSR1 -0.59 -5.53 -0.32 7.79e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg04267008 chr7:1944627 MAD1L1 -0.47 -5.64 -0.33 4.27e-8 Bipolar disorder and schizophrenia; CESC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.75 9.89 0.52 7.54e-20 Height; CESC cis rs2522056 1.000 rs2057655 chr5:131807624 A/G cg24060327 chr5:131705240 SLC22A5 -0.65 -7.27 -0.41 4.05e-12 Lymphocyte counts;Fibrinogen; CESC cis rs1005277 0.577 rs4934906 chr10:38015028 C/T cg00409905 chr10:38381863 ZNF37A -0.49 -6.57 -0.37 2.69e-10 Extrinsic epigenetic age acceleration; CESC cis rs3820928 0.874 rs4234064 chr2:227857497 G/T cg11843606 chr2:227700838 RHBDD1 -0.44 -5.65 -0.33 4.14e-8 Pulmonary function; CESC cis rs6460942 0.915 rs62447640 chr7:12488282 A/T cg06484146 chr7:12443880 VWDE -0.77 -8.63 -0.47 5.59e-16 Coronary artery disease; CESC trans rs6951245 0.529 rs10262070 chr7:1141738 C/T cg13565492 chr6:43139072 SRF -0.74 -8.99 -0.48 4.93e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg24531977 chr5:56204891 C5orf35 -0.88 -11.21 -0.57 3.87e-24 Initial pursuit acceleration; CESC cis rs703842 1.000 rs10783847 chr12:58196447 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.69 8.91 0.48 8.44e-17 Multiple sclerosis; CESC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg23422044 chr7:1970798 MAD1L1 -0.39 -5.38 -0.31 1.65e-7 Bipolar disorder and schizophrenia; CESC cis rs9300255 0.596 rs11057207 chr12:123730891 T/G cg00376283 chr12:123451042 ABCB9 0.67 8.91 0.48 8.16e-17 Neutrophil percentage of white cells; CESC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.44 -0.37 5.61e-10 Electroencephalogram traits; CESC cis rs9908102 0.756 rs7210890 chr17:12917134 A/G cg26162695 chr17:12921313 ELAC2 0.55 5.96 0.34 7.96e-9 Schizophrenia; CESC cis rs4930103 0.904 rs4929984 chr11:2024683 A/C cg23202291 chr11:1979235 NA -0.36 -5.52 -0.32 7.95e-8 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs10242455 0.702 rs10251282 chr7:98990236 T/C cg18809830 chr7:99032528 PTCD1 -0.89 -6.1 -0.35 3.84e-9 Blood metabolite levels; CESC cis rs7772486 0.790 rs1062067 chr6:146207563 A/G cg05347473 chr6:146136440 FBXO30 0.55 7.05 0.4 1.52e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg11235871 chr3:49142143 QARS 0.5 6.22 0.36 1.91e-9 Thyroid stimulating hormone; CESC cis rs244293 0.730 rs2332314 chr17:53033007 T/G cg19360675 chr17:53046073 COX11;STXBP4 -0.43 -5.74 -0.33 2.52e-8 Menarche (age at onset); CESC trans rs2273788 1.000 rs2273788 chr9:114348617 C/T cg04898443 chr2:242254495 SEPT2;HDLBP -0.6 -6.23 -0.36 1.87e-9 Monocyte count; CESC trans rs11098499 0.863 rs13136462 chr4:120543173 C/T cg25214090 chr10:38739885 LOC399744 0.69 9.52 0.5 1.14e-18 Corneal astigmatism; CESC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg18252515 chr7:66147081 NA 0.43 5.73 0.33 2.76e-8 Aortic root size; CESC trans rs11039571 0.588 rs61917001 chr11:48233667 G/C cg03929089 chr4:120376271 NA 0.64 6.2 0.36 2.2e-9 D-dimer levels; CESC cis rs9457247 0.663 rs2282861 chr6:167440128 C/T cg07741184 chr6:167504864 NA 0.34 6.09 0.35 3.9e-9 Crohn's disease; CESC cis rs634534 0.622 rs1308733 chr11:65720841 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.46 -5.63 -0.33 4.47e-8 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.5 7.43 0.42 1.47e-12 Total body bone mineral density; CESC cis rs6963495 0.818 rs73190200 chr7:105165856 T/C cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03883228 chr11:68778570 MRGPRF -0.41 -6.29 -0.36 1.29e-9 Gambling; CESC cis rs9354308 0.753 rs10455590 chr6:66598194 A/G cg07460842 chr6:66804631 NA -0.42 -5.07 -0.3 7.54e-7 Metabolite levels; CESC cis rs34779708 0.833 rs12777517 chr10:35473927 T/G cg04310649 chr10:35416472 CREM -0.51 -6.24 -0.36 1.69e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg16132339 chr22:24313637 DDTL;DDT 0.39 6.17 0.35 2.52e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3020736 0.500 rs6002597 chr22:42488160 C/A cg04733989 chr22:42467013 NAGA -0.82 -12.02 -0.59 7.23e-27 Autism spectrum disorder or schizophrenia; CESC cis rs4566357 0.615 rs10198214 chr2:227913314 A/C cg11843606 chr2:227700838 RHBDD1 -0.48 -6.58 -0.37 2.45e-10 Coronary artery disease; CESC cis rs6831352 0.877 rs29001183 chr4:100056539 C/T cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs3793683 0.597 rs12783367 chr10:134587334 T/C cg27297192 chr10:134578999 INPP5A 0.39 5.16 0.3 4.75e-7 Migraine; CESC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.49 7.05 0.4 1.58e-11 Menopause (age at onset); CESC cis rs1707322 0.721 rs10157795 chr1:46228192 G/A cg03146154 chr1:46216737 IPP 0.74 10.62 0.55 3.46e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg06873352 chr17:61820015 STRADA -0.48 -7.02 -0.4 1.87e-11 Height; CESC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg13770153 chr20:60521292 NA -0.45 -5.81 -0.34 1.75e-8 Body mass index; CESC cis rs854765 0.583 rs8078138 chr17:17811251 C/T cg04398451 chr17:18023971 MYO15A -0.65 -9.11 -0.49 2.07e-17 Total body bone mineral density; CESC cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg07636037 chr3:49044803 WDR6 1.02 18.99 0.76 2.3e-51 Parkinson's disease; CESC cis rs2901656 0.677 rs10752957 chr1:172408271 A/G cg03748243 chr1:172413542 C1orf105;PIGC 0.57 8.85 0.48 1.3e-16 Red cell distribution width;Platelet distribution width; CESC cis rs11098499 0.955 rs1511018 chr4:120161580 G/T cg09307838 chr4:120376055 NA 0.87 11.47 0.58 5.45e-25 Corneal astigmatism; CESC cis rs6964587 1.000 rs34043009 chr7:91578447 T/C cg17063962 chr7:91808500 NA -0.57 -7.62 -0.42 4.53e-13 Breast cancer; CESC cis rs77372450 0.636 rs28712355 chr5:157023508 A/G cg25077558 chr5:156991510 ADAM19 0.46 5.1 0.3 6.47e-7 Bipolar disorder (body mass index interaction); CESC cis rs2425143 0.818 rs11167280 chr20:34560526 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.58 0.32 6e-8 Blood protein levels; CESC cis rs9457247 0.534 rs9355610 chr6:167383075 G/A cg25258033 chr6:167368657 RNASET2 -0.38 -5.45 -0.32 1.15e-7 Crohn's disease; CESC cis rs7555523 0.887 rs4656461 chr1:165687205 G/A cg24409356 chr1:165738333 TMCO1 0.76 6.98 0.39 2.44e-11 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs6725517 0.737 rs7576788 chr2:25083310 A/G cg01884057 chr2:25150051 NA 0.32 6.24 0.36 1.72e-9 Breast cancer; CESC trans rs7922314 0.557 rs61865713 chr10:64737184 C/T cg06935979 chr1:232941706 KIAA1383 -0.69 -6.38 -0.36 7.94e-10 Cutaneous psoriasis; CESC cis rs9916302 0.904 rs57399933 chr17:37551189 A/G cg20243544 chr17:37824526 PNMT -0.51 -6.5 -0.37 4.03e-10 Glomerular filtration rate (creatinine); CESC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg22800045 chr5:56110881 MAP3K1 0.73 9.21 0.49 1e-17 Initial pursuit acceleration; CESC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg25405998 chr7:65216604 CCT6P1 -0.46 -5.07 -0.3 7.52e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14329673 chr8:95732141 DPY19L4 -0.48 -6.6 -0.38 2.19e-10 Fibrinogen levels; CESC cis rs7660520 0.557 rs76004373 chr4:183731011 C/G cg12483801 chr4:183727862 NA 0.75 6.88 0.39 4.24e-11 Pediatric autoimmune diseases; CESC cis rs7714584 1.000 rs7715981 chr5:150258107 A/G cg22134413 chr5:150180641 NA 0.48 5.35 0.31 1.86e-7 Crohn's disease; CESC cis rs9914988 0.943 rs12951232 chr17:27132638 G/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC trans rs3087243 0.755 rs6715389 chr2:204694621 T/C cg01841312 chr10:38069945 NA -0.38 -6.35 -0.36 9.46e-10 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs7586879 0.639 rs4077678 chr2:25122840 C/G cg01884057 chr2:25150051 NA 0.38 7.35 0.41 2.43e-12 Body mass index; CESC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.36 -0.31 1.85e-7 Menopause (age at onset); CESC cis rs2742234 0.910 rs2505511 chr10:43641029 T/A cg07801480 chr10:43725741 RASGEF1A 0.37 5.26 0.31 2.98e-7 Hirschsprung disease; CESC cis rs2573652 0.722 rs11636047 chr15:100543341 A/G cg00587665 chr15:100533223 ADAMTS17 -0.42 -6.91 -0.39 3.58e-11 Height; CESC trans rs2018683 0.707 rs917219 chr7:28975343 A/G cg19402173 chr7:128379420 CALU -0.51 -6.63 -0.38 1.85e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06932616 chr19:48908335 GRIN2D -0.5 -6.4 -0.37 7.18e-10 Gut microbiome composition (summer); CESC cis rs9905704 0.874 rs28483505 chr17:56844109 G/C cg12560992 chr17:57184187 TRIM37 0.61 7.12 0.4 9.95e-12 Testicular germ cell tumor; CESC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg24675658 chr1:53192096 ZYG11B -0.6 -7.6 -0.42 5.08e-13 Monocyte count; CESC cis rs4889855 0.530 rs9901467 chr17:78574008 G/A cg16591659 chr17:78472290 NA -0.34 -5.57 -0.32 6.41e-8 Fractional excretion of uric acid; CESC cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg18225595 chr11:63971243 STIP1 0.51 6.7 0.38 1.24e-10 Platelet count; CESC cis rs910316 0.763 rs1548807 chr14:75479582 T/G cg08847533 chr14:75593920 NEK9 0.91 16.36 0.71 4.8e-42 Height; CESC cis rs9287719 0.967 rs11674433 chr2:10730839 T/C cg02196655 chr2:10830764 NOL10 -0.36 -5.57 -0.32 6.1e-8 Prostate cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06212498 chr3:49045151 WDR6 0.47 6.04 0.35 5.15e-9 Asthma; CESC cis rs9457247 0.602 rs2157388 chr6:167481912 G/A cg23791538 chr6:167370224 RNASET2 -0.53 -6.97 -0.39 2.57e-11 Crohn's disease; CESC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg22800045 chr5:56110881 MAP3K1 0.83 9.99 0.52 3.69e-20 Initial pursuit acceleration; CESC cis rs7312933 0.567 rs11181399 chr12:42666412 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 5.97 0.34 7.71e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs314370 0.951 rs12705092 chr7:100473550 G/A cg10426581 chr7:100472382 SRRT 0.86 8.37 0.46 3.32e-15 Resting heart rate; CESC cis rs9287719 0.967 rs6759714 chr2:10747207 A/G cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs644799 1.000 rs632388 chr11:95563775 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.27 0.66 1.19e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6867032 0.695 rs3902820 chr5:2000330 T/A cg26168224 chr5:2018326 NA -0.86 -14.09 -0.65 4.81e-34 Gut microbiome composition (winter); CESC cis rs2404602 0.716 rs1125932 chr15:76820540 C/T cg26408565 chr15:76604113 ETFA -0.39 -5.72 -0.33 2.83e-8 Blood metabolite levels; CESC cis rs5769707 0.740 rs79946167 chr22:50017556 G/A cg20744362 chr22:50050164 C22orf34 0.37 6.37 0.36 8.45e-10 Monocyte count;Monocyte percentage of white cells; CESC cis rs7937682 0.663 rs35581942 chr11:111756286 C/T cg09085632 chr11:111637200 PPP2R1B 0.87 10.93 0.56 3.49e-23 Primary sclerosing cholangitis; CESC cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg24154853 chr7:158122151 PTPRN2 0.44 6.89 0.39 4.02e-11 Calcium levels; CESC cis rs1018836 0.595 rs2223010 chr8:91480068 A/G cg16814680 chr8:91681699 NA -0.63 -8.67 -0.47 4.27e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9911578 1.000 rs12449365 chr17:56600660 C/G cg12560992 chr17:57184187 TRIM37 -0.93 -15.59 -0.69 2.43e-39 Intelligence (multi-trait analysis); CESC cis rs7659604 1.000 rs35901586 chr4:122664757 T/A cg19671926 chr4:122722719 EXOSC9 -0.44 -5.3 -0.31 2.49e-7 Type 2 diabetes; CESC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.6 0.47 7.02e-16 Menopause (age at onset); CESC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg02725872 chr8:58115012 NA -0.42 -6.61 -0.38 2.1e-10 Developmental language disorder (linguistic errors); CESC trans rs3780486 1.000 rs3780480 chr9:33163486 G/T cg20290983 chr6:43655470 MRPS18A 0.84 12.08 0.6 4.54e-27 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14795305 chr7:150974453 SMARCD3 -0.59 -7.53 -0.42 8.22e-13 Gut microbiome composition (summer); CESC cis rs2797160 0.547 rs9401836 chr6:125956736 T/C cg05901451 chr6:126070800 HEY2 -0.39 -5.4 -0.32 1.45e-7 Endometrial cancer; CESC cis rs2070488 0.861 rs2067082 chr3:38438182 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.92 15.9 0.7 2.01e-40 Electrocardiographic conduction measures; CESC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg22143856 chr6:28129313 ZNF389 0.42 5.26 0.31 2.91e-7 Parkinson's disease; CESC cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC trans rs1814175 0.588 rs1721994 chr11:49914050 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs9814567 0.762 rs13079012 chr3:134247706 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.46 5.81 0.34 1.74e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs501120 0.850 rs642222 chr10:44770473 A/G cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.1e-11 Coronary artery disease;Coronary heart disease; CESC cis rs6752107 1.000 rs2241880 chr2:234183368 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.7 0.38 1.25e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs6032067 0.777 rs56063128 chr20:43783210 G/A cg11264863 chr20:43835661 SEMG1 0.5 5.41 0.32 1.4e-7 Blood protein levels; CESC cis rs2228479 0.718 rs62054253 chr16:89896932 T/C cg14709524 chr16:89940631 TCF25 0.85 5.79 0.34 1.98e-8 Skin colour saturation; CESC cis rs9858542 0.953 rs11926781 chr3:49603289 C/T cg07274523 chr3:49395745 GPX1 0.64 8.17 0.45 1.24e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs8062405 1.000 rs7498555 chr16:28893571 T/C cg08761264 chr16:28874980 SH2B1 -0.44 -5.47 -0.32 1.04e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7937682 0.883 rs1789358 chr11:111474116 G/A cg09085632 chr11:111637200 PPP2R1B -0.94 -13.87 -0.65 2.84e-33 Primary sclerosing cholangitis; CESC cis rs6496667 0.683 rs2589973 chr15:90892293 C/T cg22089800 chr15:90895588 ZNF774 0.62 7.74 0.43 2.16e-13 Rheumatoid arthritis; CESC cis rs6696846 0.791 rs11240352 chr1:205051711 C/G cg00857998 chr1:205179979 DSTYK -0.54 -7.14 -0.4 8.88e-12 Red blood cell count; CESC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg07701084 chr6:150067640 NUP43 0.48 6.85 0.39 5.03e-11 Lung cancer; CESC trans rs10100465 0.596 rs218009 chr8:118716275 A/G cg19935481 chr15:70390365 TLE3 0.66 6.6 0.38 2.2e-10 Leprosy; CESC cis rs4654899 0.865 rs1472831 chr1:21435940 C/T cg05370193 chr1:21551575 ECE1 0.45 6.86 0.39 4.86e-11 Superior frontal gyrus grey matter volume; CESC cis rs9300255 0.507 rs1615350 chr12:123650335 C/T cg05973401 chr12:123451056 ABCB9 0.46 5.8 0.34 1.88e-8 Neutrophil percentage of white cells; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11487532 chr11:44586968 CD82 -0.5 -6.71 -0.38 1.19e-10 Ulcerative colitis; CESC trans rs3749237 1.000 rs6804655 chr3:49738945 C/T cg21659725 chr3:3221576 CRBN 0.54 6.33 0.36 1.01e-9 Resting heart rate; CESC cis rs853679 1.000 rs1419183 chr6:28242794 A/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.71 7.37 0.41 2.16e-12 Depression; CESC cis rs798554 0.704 rs2527684 chr7:2825922 G/T cg19717773 chr7:2847554 GNA12 -0.56 -8.77 -0.47 2.27e-16 Height; CESC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg06494592 chr3:125709126 NA -0.49 -5.2 -0.3 3.92e-7 Blood pressure (smoking interaction); CESC cis rs12971120 0.891 rs11151960 chr18:72177232 G/A cg26446133 chr18:72167187 CNDP2 -0.76 -9.43 -0.5 2.15e-18 Refractive error; CESC cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg18305652 chr10:134549665 INPP5A 0.5 7.25 0.41 4.67e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11744524 chr6:4078970 C6orf146;C6orf201 -0.55 -6.39 -0.37 7.47e-10 Gut microbiome composition (summer); CESC cis rs3925075 1.000 rs9673404 chr16:31347592 A/T cg02846316 chr16:31340340 ITGAM 0.41 6.52 0.37 3.54e-10 IgA nephropathy; CESC cis rs17376456 0.877 rs10035340 chr5:93490465 C/T cg25358565 chr5:93447407 FAM172A 1.17 10.96 0.56 2.63e-23 Diabetic retinopathy; CESC cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg25174290 chr11:3078921 CARS 0.55 7.02 0.4 1.87e-11 Longevity; CESC cis rs992157 0.710 rs7569907 chr2:219070551 C/T cg00012203 chr2:219082015 ARPC2 0.86 12.41 0.61 3.6e-28 Colorectal cancer; CESC cis rs12822507 0.732 rs10845586 chr12:12751662 A/G cg11838227 chr12:12764436 CREBL2 -0.4 -5.5 -0.32 9.06e-8 Systemic lupus erythematosus; CESC trans rs10905099 0.708 rs71481705 chr10:7091857 G/A cg05230642 chr15:25439252 SNORD115-14 -0.73 -6.13 -0.35 3.15e-9 Orofacial clefts; CESC cis rs113835537 0.529 rs7928882 chr11:66234765 C/T cg24851651 chr11:66362959 CCS 0.46 5.68 0.33 3.57e-8 Airway imaging phenotypes; CESC cis rs1865721 0.755 rs3213875 chr18:73184048 C/T cg26385618 chr18:73139727 C18orf62 -0.41 -6.74 -0.38 9.86e-11 Intelligence; CESC cis rs9896933 0.830 rs113051447 chr17:80791806 A/G cg19500275 chr17:80737654 TBCD 0.49 5.14 0.3 5.39e-7 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs317689 0.513 rs529268 chr12:69687051 G/A cg14784868 chr12:69753453 YEATS4 0.53 6.57 0.37 2.72e-10 Response to diuretic therapy; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg21553154 chr22:36784489 MYH9 -0.47 -7.07 -0.4 1.39e-11 Vertical cup-disc ratio; CESC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg07507251 chr3:52567010 NT5DC2 0.34 5.46 0.32 1.1e-7 Bipolar disorder; CESC cis rs34311866 0.808 rs62294491 chr4:969111 C/T cg07828340 chr4:882639 GAK 0.86 6.68 0.38 1.37e-10 Parkinson's disease; CESC cis rs10752881 1.000 rs12753817 chr1:182970337 A/T ch.1.3577855R chr1:183094577 LAMC1 0.85 13.6 0.64 2.54e-32 Colorectal cancer; CESC cis rs941207 0.526 rs2255074 chr12:57030026 T/C cg05584118 chr12:57595605 LRP1 0.38 5.34 0.31 2.02e-7 Platelet count; CESC cis rs61776719 0.500 rs11210866 chr1:38449565 T/C cg12658694 chr1:38397304 INPP5B 0.65 9.42 0.5 2.36e-18 Coronary artery disease; CESC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.72 0.47 3.18e-16 Menopause (age at onset); CESC cis rs6940638 0.688 rs7744759 chr6:27119826 G/A cg12292205 chr6:26970375 C6orf41 -0.41 -5.51 -0.32 8.42e-8 Intelligence (multi-trait analysis); CESC cis rs6460942 0.597 rs6977059 chr7:12535157 T/G cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC cis rs933688 0.536 rs332537 chr5:90794973 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.81 -7.48 -0.42 1.09e-12 Smoking behavior; CESC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg12463550 chr7:65579703 CRCP -0.47 -5.96 -0.34 7.88e-9 Aortic root size; CESC cis rs9660992 0.662 rs12092492 chr1:205251880 T/C cg21643547 chr1:205240462 TMCC2 -0.48 -6.94 -0.39 2.92e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs34779708 0.702 rs4007272 chr10:35546859 T/G cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC trans rs7726839 0.540 rs55929359 chr5:595956 C/G cg25482853 chr8:67687455 SGK3 1.02 9.86 0.52 1e-19 Obesity-related traits; CESC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg21724239 chr8:58056113 NA -0.58 -5.95 -0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC cis rs7264396 0.563 rs3827029 chr20:34332784 G/T cg04508476 chr20:34239394 CPNE1;RBM12 0.84 10.63 0.55 3.3e-22 Total cholesterol levels; CESC cis rs11718455 1.000 rs1524885 chr3:44031847 G/A cg08738300 chr3:44038990 NA 0.48 6.41 0.37 6.74e-10 Coronary artery disease; CESC cis rs7165102 1.000 rs11637431 chr15:65882251 T/C cg11441148 chr15:65824328 PTPLAD1 0.32 5.39 0.31 1.53e-7 Mean corpuscular hemoglobin; CESC cis rs644799 0.511 rs10831420 chr11:95478209 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.65 9.15 0.49 1.62e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg05368731 chr17:41323189 NBR1 0.79 11.23 0.57 3.39e-24 Menopause (age at onset); CESC cis rs9527 0.545 rs10218853 chr10:104796787 A/C cg04362960 chr10:104952993 NT5C2 0.45 5.78 0.33 2.07e-8 Arsenic metabolism; CESC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg09658497 chr7:2847517 GNA12 -0.43 -6.2 -0.36 2.17e-9 Height; CESC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg11644478 chr21:40555479 PSMG1 1.03 16.81 0.72 1.13e-43 Cognitive function; CESC trans rs17764205 0.777 rs28729385 chr19:3258882 T/C cg27384338 chr17:2031545 SMG6 -0.75 -6.09 -0.35 3.9e-9 Bipolar disorder and schizophrenia; CESC cis rs4253772 0.591 rs6520010 chr22:46721223 G/A cg09491104 chr22:46646882 C22orf40 -0.59 -8.67 -0.47 4.32e-16 LDL cholesterol;Cholesterol, total; CESC cis rs7617773 0.779 rs11718329 chr3:48309828 C/G cg11946769 chr3:48343235 NME6 0.77 10.14 0.53 1.25e-20 Coronary artery disease; CESC cis rs873946 0.564 rs2803991 chr10:134557068 A/G cg27286337 chr10:134555280 INPP5A 0.68 8.6 0.47 7.11e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs950776 0.684 rs61012457 chr15:78865694 C/G cg06917634 chr15:78832804 PSMA4 0.61 7.5 0.42 9.8e-13 Sudden cardiac arrest; CESC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg03676636 chr4:99064102 C4orf37 0.34 5.07 0.3 7.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.706 rs11657153 chr17:37699729 A/G cg07936489 chr17:37558343 FBXL20 -0.98 -11.47 -0.58 5.54e-25 Glomerular filtration rate (creatinine); CESC cis rs854765 0.583 rs8078138 chr17:17811251 C/T cg09796270 chr17:17721594 SREBF1 0.46 6.39 0.37 7.34e-10 Total body bone mineral density; CESC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg22029157 chr1:209979665 IRF6 0.69 9.02 0.48 3.96e-17 Cleft lip with or without cleft palate; CESC cis rs7659604 1.000 rs6816071 chr4:122665185 G/A cg19671926 chr4:122722719 EXOSC9 -0.49 -5.89 -0.34 1.14e-8 Type 2 diabetes; CESC trans rs11098499 0.909 rs11723839 chr4:120299673 G/A cg25214090 chr10:38739885 LOC399744 0.68 9.16 0.49 1.46e-17 Corneal astigmatism; CESC cis rs3793683 0.520 rs4880426 chr10:134590610 G/A cg27297192 chr10:134578999 INPP5A 0.4 5.42 0.32 1.36e-7 Migraine; CESC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg18016565 chr1:150552671 MCL1 0.33 5.16 0.3 4.96e-7 Tonsillectomy; CESC cis rs8044868 0.512 rs10048144 chr16:72052891 C/G cg01557791 chr16:72042693 DHODH -0.42 -5.65 -0.33 4.14e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs6424115 1.000 rs1018396 chr1:24133612 G/A cg15997130 chr1:24165203 NA 0.44 6.2 0.36 2.18e-9 Immature fraction of reticulocytes; CESC cis rs2354432 0.607 rs2353999 chr1:146830686 T/C cg25205988 chr1:146714368 CHD1L -0.99 -8.69 -0.47 3.77e-16 Mitochondrial DNA levels; CESC cis rs17253792 0.822 rs77555779 chr14:56078430 A/G cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.57 0.32 6.26e-8 Bipolar disorder; CESC cis rs2952156 0.920 rs1476278 chr17:37836243 C/T cg20243544 chr17:37824526 PNMT 0.64 8.63 0.47 5.62e-16 Asthma; CESC trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21659725 chr3:3221576 CRBN -0.83 -13.35 -0.63 1.98e-31 Intelligence (multi-trait analysis); CESC cis rs9908102 0.770 rs8071726 chr17:12914584 C/T cg26162695 chr17:12921313 ELAC2 0.53 6.12 0.35 3.26e-9 Schizophrenia; CESC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg27297192 chr10:134578999 INPP5A -0.39 -5.19 -0.3 4.12e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs861020 0.606 rs629224 chr1:210005071 C/T cg05527609 chr1:210001259 C1orf107 0.73 9.55 0.51 9.08e-19 Orofacial clefts; CESC trans rs877282 0.853 rs7069720 chr10:754487 A/G cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg16132339 chr22:24313637 DDTL;DDT 0.38 5.84 0.34 1.52e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6032067 0.929 rs2868238 chr20:43826993 C/G cg10761708 chr20:43804764 PI3 0.53 6.39 0.37 7.37e-10 Blood protein levels; CESC cis rs1126510 0.897 rs9304662 chr19:47121745 A/G cg07844738 chr19:47129343 PTGIR 0.32 5.11 0.3 6.08e-7 Ulcerative colitis; CESC cis rs1707322 1.000 rs10890376 chr1:46406582 C/T cg05343316 chr1:45956843 TESK2 0.5 6.13 0.35 3.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10979 0.931 rs9403509 chr6:143888691 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs921968 0.565 rs12611632 chr2:219621258 C/T cg02176678 chr2:219576539 TTLL4 -0.44 -7.67 -0.43 3.29e-13 Mean corpuscular hemoglobin concentration; CESC cis rs7523050 0.643 rs7551313 chr1:109399881 G/A cg08274380 chr1:109419600 GPSM2 0.83 5.58 0.32 5.89e-8 Fat distribution (HIV); CESC cis rs6741892 0.536 rs6761563 chr2:38891406 A/T cg08308459 chr2:38893161 GALM -0.55 -6.75 -0.38 9.44e-11 5-HTT brain serotonin transporter levels; CESC cis rs2857078 0.654 rs9896789 chr17:42314567 C/T cg08499158 chr17:42289980 UBTF -0.49 -6.02 -0.35 5.77e-9 Red cell distribution width;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26398656 chr18:21852327 OSBPL1A -0.52 -6.27 -0.36 1.43e-9 Gut microbiome composition (summer); CESC cis rs4268898 0.552 rs11125455 chr2:24374557 C/G cg20701182 chr2:24300061 SF3B14 -0.38 -5.28 -0.31 2.72e-7 Asthma; CESC cis rs7617773 0.780 rs34589064 chr3:48339549 G/A cg11946769 chr3:48343235 NME6 0.89 12.11 0.6 3.63e-27 Coronary artery disease; CESC cis rs1784581 0.851 rs1784591 chr6:162388893 C/G cg17173639 chr6:162384350 PARK2 -0.82 -13.59 -0.64 2.74e-32 Itch intensity from mosquito bite; CESC trans rs3741489 1.000 rs2062161 chr12:133428032 G/A cg24132527 chr5:140019269 TMCO6 1.1 7.42 0.41 1.61e-12 Cognitive function; CESC cis rs2249694 0.960 rs7084384 chr10:135412322 A/G cg20169779 chr10:135381914 SYCE1 -0.4 -5.65 -0.33 4.05e-8 Obesity-related traits; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg09472203 chr15:83378614 AP3B2 0.49 6.12 0.35 3.4e-9 Psoriatic arthritis; CESC cis rs7814319 0.901 rs13253635 chr8:97240847 A/G cg20787634 chr8:97240163 UQCRB -0.63 -8.2 -0.45 1.03e-14 Lung function (FVC); CESC cis rs6964587 0.967 rs12671991 chr7:91559481 T/C cg17063962 chr7:91808500 NA -0.59 -7.88 -0.44 8.67e-14 Breast cancer; CESC cis rs75229567 0.717 rs77874289 chr12:70234203 A/G cg10114359 chr12:70132523 RAB3IP 0.89 6.44 0.37 5.52e-10 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs4076764 0.846 rs12036398 chr1:163422204 C/T cg24596788 chr1:163392923 NA 0.4 5.63 0.33 4.55e-8 Motion sickness; CESC trans rs1728785 1.000 rs1170429 chr16:68604126 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.93 0.44 6e-14 Ulcerative colitis; CESC trans rs9325144 0.556 rs34565156 chr12:39028239 G/A cg23762105 chr12:34175262 ALG10 0.47 6.1 0.35 3.73e-9 Morning vs. evening chronotype; CESC cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg11890956 chr21:40555474 PSMG1 0.69 9.49 0.5 1.38e-18 Cognitive function; CESC cis rs854765 0.583 rs11650890 chr17:17790882 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.52 -7.21 -0.4 5.86e-12 Total body bone mineral density; CESC cis rs2404602 0.692 rs35999717 chr15:77193367 G/C cg26408565 chr15:76604113 ETFA -0.39 -5.68 -0.33 3.56e-8 Blood metabolite levels; CESC trans rs11098499 0.954 rs13107475 chr4:120393011 A/T cg25214090 chr10:38739885 LOC399744 0.71 10.33 0.54 3.07e-21 Corneal astigmatism; CESC cis rs17253792 0.822 rs77415412 chr14:56154146 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs2066819 1.000 rs77120931 chr12:56646213 A/C cg26714650 chr12:56694279 CS -1.43 -10.51 -0.54 7.79e-22 Psoriasis vulgaris; CESC cis rs11098499 0.954 rs12502423 chr4:120424172 A/C cg09307838 chr4:120376055 NA 0.93 13.0 0.62 3.31e-30 Corneal astigmatism; CESC cis rs548181 0.536 rs503288 chr11:125461787 C/T cg03464685 chr11:125439445 EI24 -0.94 -8.74 -0.47 2.7e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -5.7 -0.33 3.12e-8 Extrinsic epigenetic age acceleration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20574949 chr11:9336117 TMEM41B 0.47 6.21 0.36 2.06e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg25019033 chr10:957182 NA -0.6 -5.84 -0.34 1.54e-8 Eosinophil percentage of granulocytes; CESC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg13393036 chr8:95962371 TP53INP1 -0.49 -10.52 -0.54 7.38e-22 Type 2 diabetes; CESC cis rs863345 0.604 rs10908660 chr1:158466189 G/A cg12129480 chr1:158549410 OR10X1 -0.36 -7.13 -0.4 9.54e-12 Pneumococcal bacteremia; CESC trans rs6951245 0.554 rs78999139 chr7:1138525 G/A cg13565492 chr6:43139072 SRF -0.75 -9.04 -0.49 3.45e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.659 rs9611604 chr22:41916001 C/G cg06634786 chr22:41940651 POLR3H -0.7 -7.15 -0.4 8.38e-12 Vitiligo; CESC cis rs7432375 0.641 rs835649 chr3:136671890 G/A cg15507776 chr3:136538369 TMEM22 0.59 7.58 0.42 5.7e-13 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.44 0.42 1.41e-12 Height; CESC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg18402987 chr7:1209562 NA 0.59 7.0 0.4 2.06e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7561273 0.586 rs4149372 chr2:24305512 T/G cg20701182 chr2:24300061 SF3B14 0.52 6.67 0.38 1.45e-10 Quantitative traits; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg01925094 chr20:36322369 CTNNBL1 0.52 6.0 0.35 6.47e-9 Psoriatic arthritis; CESC cis rs317689 0.581 rs160829 chr12:69769538 G/C cg14784868 chr12:69753453 YEATS4 0.73 9.61 0.51 6.01e-19 Response to diuretic therapy; CESC cis rs7220401 0.512 rs2289629 chr17:27959903 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 5.84 0.34 1.53e-8 Coronary artery disease; CESC cis rs17384381 0.953 rs3768223 chr1:85809183 T/C cg16011679 chr1:85725395 C1orf52 0.8 8.2 0.45 1.03e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg21770322 chr7:97807741 LMTK2 0.55 8.0 0.44 3.92e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg09699651 chr6:150184138 LRP11 0.45 5.46 0.32 1.11e-7 Lung cancer; CESC cis rs10752881 1.000 rs4402094 chr1:182986441 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.79e-31 Colorectal cancer; CESC cis rs6061231 0.505 rs13037253 chr20:60928724 G/A cg24112000 chr20:60950667 NA -0.51 -6.31 -0.36 1.16e-9 Colorectal cancer; CESC cis rs950776 0.518 rs4887063 chr15:78839715 C/T cg06917634 chr15:78832804 PSMA4 -0.73 -10.45 -0.54 1.24e-21 Sudden cardiac arrest; CESC trans rs60380162 0.963 rs72725861 chr1:87726780 C/T cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.03 -0.35 5.48e-9 Loneliness (linear analysis); CESC cis rs8072100 0.576 rs12948299 chr17:45403057 T/C cg25173405 chr17:45401733 C17orf57 -0.5 -5.85 -0.34 1.47e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs17433780 0.504 rs6428494 chr1:89472196 C/T cg09516651 chr1:89888402 LOC400759 0.48 6.71 0.38 1.17e-10 Carotid intima media thickness; CESC cis rs12477438 0.798 rs6705821 chr2:99602832 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs10832963 1.000 rs10832962 chr11:18656271 C/T cg09201001 chr11:18656081 SPTY2D1 0.82 12.42 0.61 3.32e-28 Breast cancer; CESC cis rs73206853 0.563 rs73194032 chr12:111162182 G/A cg12870014 chr12:110450643 ANKRD13A 0.64 5.66 0.33 3.91e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7771547 0.573 rs544267 chr6:36398302 A/G cg04289385 chr6:36355825 ETV7 0.38 5.57 0.32 6.41e-8 Platelet distribution width; CESC cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg13902645 chr11:5959945 NA -0.66 -7.93 -0.44 6.29e-14 DNA methylation (variation); CESC cis rs9943465 0.688 rs318929 chr10:132071772 T/C cg12765123 chr10:132100019 NA 0.42 5.13 0.3 5.64e-7 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs919433 0.963 rs6738836 chr2:198182432 A/G cg03934865 chr2:198174659 NA -0.4 -5.46 -0.32 1.09e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7833986 0.534 rs17814089 chr8:56965563 A/G cg26371346 chr8:56986568 SNORD54;RPS20 -0.57 -5.21 -0.3 3.82e-7 Height; CESC cis rs1729951 0.575 rs361244 chr3:136697506 C/T cg04103450 chr3:136751342 NA 0.4 5.35 0.31 1.92e-7 Neuroticism; CESC cis rs4588572 0.688 rs2115436 chr5:77692617 A/T cg11547950 chr5:77652471 NA -0.42 -5.94 -0.34 8.76e-9 Triglycerides; CESC cis rs265548 0.608 rs36690 chr19:17910483 C/T cg21960279 chr19:17905606 B3GNT3 0.48 7.09 0.4 1.22e-11 Tumor biomarkers; CESC cis rs2380220 0.606 rs4559095 chr6:95994154 A/C cg23517279 chr6:96025343 MANEA 0.51 5.54 0.32 7.25e-8 Behavioural disinhibition (generation interaction); CESC cis rs4660306 0.961 rs2991966 chr1:45999503 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.6 -7.58 -0.42 5.74e-13 Homocysteine levels; CESC trans rs7178375 1.000 rs7169064 chr15:31210862 C/T cg04373760 chr16:53404718 NA 0.53 7.19 0.4 6.74e-12 Hypertriglyceridemia; CESC cis rs9287719 0.967 rs12622765 chr2:10728331 T/C cg02196655 chr2:10830764 NOL10 -0.36 -5.57 -0.32 6.1e-8 Prostate cancer; CESC cis rs7786808 0.525 rs10253961 chr7:158194858 G/A cg09998033 chr7:158218633 PTPRN2 0.35 5.37 0.31 1.73e-7 Obesity-related traits; CESC cis rs6088590 1.000 rs6087625 chr20:33342477 A/G cg24642439 chr20:33292090 TP53INP2 -0.85 -11.88 -0.59 2.28e-26 Coronary artery disease; CESC cis rs7084402 0.565 rs10826200 chr10:60333847 T/C cg07615347 chr10:60278583 BICC1 0.38 5.45 0.32 1.17e-7 Refractive error; CESC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -5.47 -0.32 1.03e-7 Platelet count; CESC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC cis rs2066819 1.000 rs75754909 chr12:56726349 A/G cg26714650 chr12:56694279 CS -1.39 -9.17 -0.49 1.33e-17 Psoriasis vulgaris; CESC cis rs644799 0.542 rs10831416 chr11:95467220 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.42 5.3 0.31 2.48e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05162533 chr17:74137399 FOXJ1 -0.58 -6.61 -0.38 2.05e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00033668 chr12:15942561 EPS8 0.53 6.03 0.35 5.56e-9 Gut microbiome composition (summer); CESC cis rs6594713 0.717 rs10056194 chr5:112857862 T/G cg12552261 chr5:112820674 MCC 0.55 5.55 0.32 6.78e-8 Brain cytoarchitecture; CESC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg08736216 chr1:53307985 ZYG11A -0.43 -7.17 -0.4 7.3e-12 Monocyte count; CESC cis rs2637266 1.000 rs2395386 chr10:78341623 C/T cg18941641 chr10:78392320 NA 0.38 7.16 0.4 7.8e-12 Pulmonary function; CESC cis rs6987853 0.787 rs12677427 chr8:42414226 T/A cg09913449 chr8:42400586 C8orf40 0.45 7.44 0.42 1.39e-12 Mean corpuscular hemoglobin concentration; CESC cis rs3796352 1.000 rs11712653 chr3:53070875 A/C cg12962167 chr3:53033115 SFMBT1 -0.6 -5.45 -0.32 1.16e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 7.6 0.42 5.06e-13 Bipolar disorder; CESC cis rs5753618 0.504 rs5753671 chr22:31910734 T/C cg00478049 chr22:31556069 RNF185 -0.46 -5.59 -0.32 5.63e-8 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13627451 chr15:52043674 TMOD2;LYSMD2 0.6 7.21 0.4 5.73e-12 Gut microbiome composition (summer); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg23284323 chr21:40685679 BRWD1 0.42 6.08 0.35 4.08e-9 Tetralogy of Fallot; CESC cis rs6963495 0.818 rs73192125 chr7:105175068 A/C cg02135003 chr7:105160482 PUS7 -0.44 -5.62 -0.33 4.79e-8 Bipolar disorder (body mass index interaction); CESC cis rs10751667 0.643 rs10902244 chr11:949981 A/G cg06064525 chr11:970664 AP2A2 -0.49 -9.81 -0.52 1.42e-19 Alzheimer's disease (late onset); CESC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg05564831 chr3:52568323 NT5DC2 0.45 7.01 0.4 2.03e-11 Bipolar disorder; CESC cis rs2249694 1.000 rs4240522 chr10:135355557 C/T cg20169779 chr10:135381914 SYCE1 0.42 5.74 0.33 2.58e-8 Obesity-related traits; CESC cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -8.33 -0.46 4.44e-15 Developmental language disorder (linguistic errors); CESC cis rs10791097 0.720 rs4936121 chr11:130733878 A/G cg12179176 chr11:130786555 SNX19 0.65 9.92 0.52 6.44e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.29 -0.31 2.52e-7 Lung cancer; CESC cis rs1062177 0.951 rs2915876 chr5:151150745 C/A cg12924095 chr5:151150029 G3BP1 0.48 6.14 0.35 2.94e-9 Preschool internalizing problems; CESC cis rs5760092 0.618 rs4461358 chr22:24260106 T/C cg11905131 chr22:24372483 LOC391322 0.64 8.02 0.44 3.34e-14 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs6681460 0.901 rs1570815 chr1:67139667 C/T cg02459107 chr1:67143332 SGIP1 0.38 5.25 0.31 3.16e-7 Presence of antiphospholipid antibodies; CESC cis rs6736093 0.933 rs4848229 chr2:112692650 C/A cg12686935 chr2:112915763 FBLN7 -0.44 -5.72 -0.33 2.86e-8 Coronary artery disease; CESC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg12963246 chr6:28129442 ZNF389 0.56 7.4 0.41 1.8e-12 Depression; CESC cis rs644799 0.526 rs530914 chr11:95632156 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.46 6.03 0.35 5.51e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg02951883 chr7:2050386 MAD1L1 -0.51 -6.62 -0.38 2.04e-10 Bipolar disorder and schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01669482 chr16:25043131 NA 0.55 7.17 0.4 7.37e-12 Gut microbiota (bacterial taxa); CESC cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg27297192 chr10:134578999 INPP5A 0.37 5.05 0.3 8.04e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg00129232 chr17:37814104 STARD3 -0.57 -7.49 -0.42 1.01e-12 Glomerular filtration rate (creatinine); CESC cis rs2985684 1.000 rs17121651 chr14:50097172 T/C cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.43 -5.14 -0.3 5.39e-7 Carotid intima media thickness; CESC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg23161317 chr6:28129485 ZNF389 0.4 5.69 0.33 3.29e-8 Cardiac Troponin-T levels; CESC cis rs796364 0.865 rs769948 chr2:200728475 C/A cg23649088 chr2:200775458 C2orf69 0.54 5.1 0.3 6.38e-7 Schizophrenia; CESC cis rs9905704 0.627 rs1267544 chr17:56643398 T/G cg12560992 chr17:57184187 TRIM37 -0.61 -6.3 -0.36 1.24e-9 Testicular germ cell tumor; CESC cis rs9487051 0.799 rs351724 chr6:109546577 T/C cg01475377 chr6:109611718 NA -0.38 -5.74 -0.33 2.63e-8 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02580404 chr16:19729857 C16orf88;IQCK 0.57 6.61 0.38 2.11e-10 Gut microbiome composition (summer); CESC cis rs1801251 0.778 rs2675967 chr2:233736133 C/G cg25237894 chr2:233734115 C2orf82 -0.58 -9.36 -0.5 3.54e-18 Coronary artery disease; CESC cis rs34638657 0.702 rs12599946 chr16:82199831 T/C cg09439754 chr16:82129088 HSD17B2 -0.37 -6.42 -0.37 6.31e-10 Lung adenocarcinoma; CESC cis rs2820292 0.619 rs41299585 chr1:201853165 G/T cg11586189 chr1:201857591 SHISA4 -0.37 -5.91 -0.34 1.06e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21595526 chr15:50647267 GABPB1;LOC100129387;FLJ10038 -0.49 -6.26 -0.36 1.58e-9 Asthma; CESC cis rs55728055 0.661 rs75785548 chr22:31991363 C/T cg01338084 chr22:32026380 PISD 1.22 8.02 0.44 3.48e-14 Age-related hearing impairment; CESC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg23281280 chr6:28129359 ZNF389 0.47 6.51 0.37 3.76e-10 Parkinson's disease; CESC cis rs9467711 0.606 rs9358937 chr6:26374274 C/G cg14345882 chr6:26364793 BTN3A2 0.59 5.92 0.34 1.01e-8 Autism spectrum disorder or schizophrenia; CESC cis rs963731 0.649 rs297140 chr2:39319121 A/G cg04010122 chr2:39346883 SOS1 -0.74 -5.39 -0.31 1.54e-7 Corticobasal degeneration; CESC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg04369109 chr6:150039330 LATS1 -0.37 -5.07 -0.3 7.4e-7 Lung cancer; CESC cis rs17376456 0.877 rs34595581 chr5:93369422 G/A cg21475434 chr5:93447410 FAM172A 0.8 6.98 0.39 2.35e-11 Diabetic retinopathy; CESC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.61 -0.33 5.22e-8 Total body bone mineral density; CESC cis rs2486288 0.656 rs1719232 chr15:45572072 A/G cg21132104 chr15:45694354 SPATA5L1 -0.62 -7.26 -0.41 4.19e-12 Glomerular filtration rate; CESC cis rs1008375 0.902 rs7654332 chr4:17691778 A/T cg16339924 chr4:17578868 LAP3 0.63 7.67 0.43 3.27e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2932538 0.922 rs12402469 chr1:113076625 G/A cg22162597 chr1:113214053 CAPZA1 0.53 6.59 0.38 2.32e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg06420487 chr17:61919686 SMARCD2 0.44 5.28 0.31 2.68e-7 Height; CESC cis rs7020830 0.861 rs2291589 chr9:37079661 T/G cg14294708 chr9:37120828 ZCCHC7 1.26 25.15 0.84 3.81e-72 Schizophrenia; CESC cis rs35110281 0.627 rs6518268 chr21:44967448 A/G cg21573476 chr21:45109991 RRP1B -0.38 -5.23 -0.31 3.44e-7 Mean corpuscular volume; CESC cis rs1790761 0.772 rs36089024 chr11:67244644 C/T cg14500267 chr11:67383377 NA -0.31 -5.13 -0.3 5.61e-7 Mean corpuscular volume; CESC cis rs1153858 1.000 rs12909158 chr15:45621174 A/G cg14582100 chr15:45693742 SPATA5L1 0.41 5.71 0.33 3.08e-8 Homoarginine levels; CESC cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg24846343 chr22:24311635 DDTL 0.59 9.51 0.5 1.21e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1580019 0.587 rs34488151 chr7:32548146 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.8 0.76 1.12e-50 Cognitive ability; CESC cis rs787274 1.000 rs787301 chr9:115542737 G/T cg13803584 chr9:115635662 SNX30 0.55 5.27 0.31 2.9e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.700 rs12449555 chr17:62003982 T/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.57 -7.04 -0.4 1.63e-11 Prudent dietary pattern; CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg12419862 chr22:24373484 LOC391322 -0.82 -12.14 -0.6 2.98e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3793683 0.545 rs12784446 chr10:134589094 T/G cg27286337 chr10:134555280 INPP5A 0.63 7.29 0.41 3.62e-12 Migraine; CESC cis rs1008375 1.000 rs11724495 chr4:17621310 G/A cg04450456 chr4:17643702 FAM184B 0.37 5.29 0.31 2.51e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs763121 0.814 rs5757212 chr22:39053757 G/C cg21395723 chr22:39101663 GTPBP1 0.5 6.72 0.38 1.1e-10 Menopause (age at onset); CESC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.63 0.38 1.89e-10 Prudent dietary pattern; CESC cis rs13191362 0.507 rs2849534 chr6:163144657 T/A cg21926612 chr6:163149169 PACRG;PARK2 -0.51 -6.1 -0.35 3.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg01159515 chr5:127420616 SLC12A2 -0.48 -6.2 -0.36 2.1e-9 Thyroid stimulating hormone; CESC cis rs1062177 1.000 rs2964578 chr5:151147198 T/A cg12924095 chr5:151150029 G3BP1 0.48 6.15 0.35 2.82e-9 Preschool internalizing problems; CESC cis rs2014572 0.967 rs10412975 chr19:57770554 C/A cg24459738 chr19:57751996 ZNF805 -0.53 -7.46 -0.42 1.23e-12 Hyperactive-impulsive symptoms; CESC cis rs6499255 0.951 rs7200935 chr16:69564497 T/C cg15192750 chr16:69999425 NA 0.55 6.43 0.37 6.07e-10 IgE levels; CESC cis rs9486719 0.552 rs9399923 chr6:96850379 G/A cg18709589 chr6:96969512 KIAA0776 0.44 5.15 0.3 5.19e-7 Migraine;Coronary artery disease; CESC cis rs2816062 0.775 rs2816046 chr1:18893708 A/G cg18795169 chr1:18902165 NA -0.9 -17.73 -0.74 6.5e-47 Urate levels in lean individuals; CESC cis rs13095912 0.512 rs115865582 chr3:185308598 A/C cg11274856 chr3:185301563 NA 0.36 5.34 0.31 1.95e-7 Systolic blood pressure; CESC trans rs13360092 0.764 rs9283700 chr5:50561921 T/C cg03200537 chr16:87022121 NA 0.68 6.0 0.35 6.57e-9 Verbal declarative memory; CESC cis rs17253792 0.732 rs28380739 chr14:56088402 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC trans rs801193 1.000 rs62466793 chr7:66191517 G/A cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg18538332 chr22:24372958 LOC391322 -0.71 -10.34 -0.54 2.74e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4955124 0.558 rs62244405 chr3:32037605 G/A cg05935571 chr3:32023257 ZNF860;OSBPL10 0.96 7.02 0.4 1.91e-11 Schizophrenia; CESC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg27170947 chr2:26402098 FAM59B -0.58 -6.85 -0.39 5.06e-11 Gut microbiome composition (summer); CESC cis rs4481887 1.000 rs6666690 chr1:248465323 T/C cg00666640 chr1:248458726 OR2T12 0.37 6.04 0.35 5.32e-9 Common traits (Other); CESC cis rs7851660 0.527 rs7859751 chr9:100575888 C/T cg13688889 chr9:100608707 NA -0.88 -14.33 -0.66 7.23e-35 Strep throat; CESC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg05564831 chr3:52568323 NT5DC2 0.45 6.91 0.39 3.55e-11 Bipolar disorder; CESC cis rs7605827 0.930 rs13019216 chr2:15659539 A/G cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.65e-10 Educational attainment (years of education); CESC cis rs2637266 0.600 rs11001823 chr10:78326767 G/A cg18941641 chr10:78392320 NA -0.34 -5.22 -0.31 3.68e-7 Pulmonary function; CESC cis rs72781680 0.898 rs72782113 chr2:24024952 G/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs2011503 1.000 rs6511029 chr19:19471419 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.53 -5.34 -0.31 1.98e-7 Bipolar disorder; CESC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg26335602 chr6:28129616 ZNF389 0.38 5.39 0.31 1.57e-7 Cardiac Troponin-T levels; CESC cis rs7100689 0.646 rs1953971 chr10:82145647 G/C cg00277334 chr10:82204260 NA -0.58 -7.62 -0.42 4.52e-13 Post bronchodilator FEV1; CESC cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.76 6.81 0.39 6.69e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg17650747 chr5:1873721 NA 0.43 5.87 0.34 1.28e-8 Cardiovascular disease risk factors; CESC cis rs2072732 0.821 rs10909864 chr1:2948178 T/C cg15211996 chr1:2936768 ACTRT2 0.32 5.82 0.34 1.7e-8 Plateletcrit; CESC cis rs3213545 0.700 rs2260445 chr12:121468863 C/A cg25281562 chr12:121454272 C12orf43 0.4 5.06 0.3 8.03e-7 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs28374715 0.627 rs28516832 chr15:41367036 G/A cg18705301 chr15:41695430 NDUFAF1 -0.83 -10.44 -0.54 1.39e-21 Ulcerative colitis; CESC cis rs6500395 1.000 rs34844432 chr16:48682418 C/T cg04672837 chr16:48644449 N4BP1 0.51 6.36 0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7617773 0.963 rs6766754 chr3:48182589 T/C cg11946769 chr3:48343235 NME6 -0.61 -8.18 -0.45 1.18e-14 Coronary artery disease; CESC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg08470875 chr2:26401718 FAM59B -0.7 -7.52 -0.42 8.6e-13 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 7.8 0.43 1.41e-13 Menopause (age at onset); CESC cis rs568617 0.859 rs1204650 chr11:65645580 A/C cg04055107 chr11:65626734 MUS81;CFL1 -0.69 -7.4 -0.41 1.81e-12 Crohn's disease; CESC cis rs17253792 0.822 rs28409547 chr14:56047826 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.88 0.34 1.25e-8 Putamen volume; CESC cis rs778371 0.723 rs10210953 chr2:233698830 G/A cg08000102 chr2:233561755 GIGYF2 -0.84 -14.5 -0.67 1.84e-35 Schizophrenia; CESC cis rs12973672 1.000 rs1051995 chr19:35770292 C/T cg12095397 chr19:35769544 USF2 0.54 7.35 0.41 2.49e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs9325144 0.647 rs35138700 chr12:38804474 C/T cg10679878 chr6:156759499 NA -0.33 -6.02 -0.35 5.73e-9 Morning vs. evening chronotype; CESC cis rs17376456 0.825 rs13156202 chr5:93157721 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 -0.61 -5.23 -0.31 3.48e-7 Diabetic retinopathy; CESC cis rs7107174 1.000 rs2512537 chr11:77971947 T/C cg02023728 chr11:77925099 USP35 0.48 6.34 0.36 9.87e-10 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09251995 chr19:18392994 JUND -0.59 -6.58 -0.37 2.55e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.686 rs857883 chr6:145969214 G/T cg23711669 chr6:146136114 FBXO30 -0.98 -15.19 -0.68 6.34e-38 Lobe attachment (rater-scored or self-reported); CESC trans rs6084875 0.620 rs4813711 chr20:4722646 T/G cg10192164 chr16:30419175 ZNF771 -0.5 -6.16 -0.35 2.7e-9 Systemic lupus erythematosus; CESC cis rs60733400 0.500 rs72644697 chr1:2533605 G/A cg20673091 chr1:2541236 MMEL1 0.43 7.22 0.41 5.36e-12 Multiple sclerosis; CESC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.38 5.06 0.3 7.89e-7 Menopause (age at onset); CESC cis rs7223966 1.000 rs9901507 chr17:61765524 G/A cg11494091 chr17:61959527 GH2 0.38 5.42 0.32 1.33e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs11969893 0.850 rs9390697 chr6:101294431 G/A cg12253828 chr6:101329408 ASCC3 1.12 9.48 0.5 1.56e-18 Economic and political preferences (immigration/crime); CESC cis rs8014204 0.935 rs1799900 chr14:75367740 G/A cg26191576 chr14:75389716 RPS6KL1 0.36 5.25 0.31 3.06e-7 Caffeine consumption; CESC cis rs8133932 0.654 rs10854475 chr21:47332749 A/G cg14185626 chr21:47401492 COL6A1 0.46 5.12 0.3 5.88e-7 Schizophrenia; CESC cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg05347473 chr6:146136440 FBXO30 0.55 7.06 0.4 1.45e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs12145833 0.538 rs12026408 chr1:243366805 G/A cg02356786 chr1:243265016 LOC731275 0.81 6.54 0.37 3.07e-10 Obesity (early onset extreme); CESC cis rs8077577 0.747 rs2294913 chr17:18202996 C/T cg16794390 chr17:18148240 FLII 0.41 6.45 0.37 5.26e-10 Obesity-related traits; CESC cis rs7524258 0.900 rs7514988 chr1:7271651 C/T cg07173049 chr1:7289937 CAMTA1 0.34 5.21 0.3 3.74e-7 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs1707322 1.000 rs2458400 chr1:46530798 C/T cg03146154 chr1:46216737 IPP -0.7 -9.2 -0.49 1.08e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6459788 0.720 rs11974772 chr7:157250645 G/A cg06271696 chr7:157225062 NA -0.36 -5.08 -0.3 7.23e-7 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg17221315 chr6:27791827 HIST1H4J 0.47 5.06 0.3 7.72e-7 Parkinson's disease; CESC cis rs116095464 0.558 rs60251075 chr5:245292 T/C cg20965017 chr5:231967 SDHA -0.47 -5.38 -0.31 1.65e-7 Breast cancer; CESC cis rs10905065 0.965 rs2890365 chr10:5773876 C/A cg11519256 chr10:5708881 ASB13 -0.42 -5.64 -0.33 4.39e-8 Menopause (age at onset); CESC cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg24110177 chr3:50126178 RBM5 0.53 7.28 0.41 3.85e-12 Intelligence (multi-trait analysis); CESC cis rs6088590 0.930 rs6087618 chr20:33288407 C/T cg08999081 chr20:33150536 PIGU 0.59 9.21 0.49 1.04e-17 Coronary artery disease; CESC cis rs2204008 0.775 rs12099736 chr12:38344111 C/G cg26384229 chr12:38710491 ALG10B 0.73 10.93 0.56 3.37e-23 Bladder cancer; CESC cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg27266027 chr21:40555129 PSMG1 0.49 5.8 0.34 1.89e-8 Cognitive function; CESC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg25072359 chr17:41440525 NA -0.44 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC cis rs6831352 0.918 rs34936974 chr4:100052384 A/G cg12011299 chr4:100065546 ADH4 0.45 5.3 0.31 2.41e-7 Alcohol dependence; CESC cis rs1847202 0.762 rs62249896 chr3:72949857 C/G cg10804678 chr3:72788309 NA -0.4 -5.32 -0.31 2.26e-7 Motion sickness; CESC cis rs6502050 0.835 rs35131307 chr17:80128439 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.97e-7 Life satisfaction; CESC cis rs72781680 0.678 rs56145919 chr2:24088489 A/G cg08917208 chr2:24149416 ATAD2B 0.58 5.78 0.33 2.07e-8 Lymphocyte counts; CESC cis rs2760061 0.626 rs635563 chr1:228136834 C/T cg01973587 chr1:228161476 NA 0.37 5.75 0.33 2.47e-8 Diastolic blood pressure; CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.42 8.22 0.45 9.35e-15 Electroencephalogram traits; CESC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.68 0.33 3.49e-8 Personality dimensions; CESC cis rs1998418 0.736 rs10901804 chr10:126366238 T/C cg03585084 chr10:126284563 LHPP 0.53 5.12 0.3 5.74e-7 Mean platelet volume; CESC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg16545954 chr1:2118288 C1orf86 -0.33 -6.05 -0.35 5e-9 Height; CESC cis rs2046867 0.818 rs11928620 chr3:72863209 A/C cg25664220 chr3:72788482 NA -0.47 -6.98 -0.39 2.32e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs7927771 0.524 rs11039329 chr11:47684908 A/G cg18512352 chr11:47633146 NA 0.34 5.08 0.3 7.18e-7 Subjective well-being; CESC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg27427491 chr17:78079615 GAA -0.39 -6.04 -0.35 5.13e-9 Yeast infection; CESC cis rs7927771 0.524 rs10742814 chr11:47554337 G/A cg20307385 chr11:47447363 PSMC3 0.63 8.74 0.47 2.71e-16 Subjective well-being; CESC cis rs858239 0.601 rs15775 chr7:23164701 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.73 0.43 2.27e-13 Cerebrospinal fluid biomarker levels; CESC cis rs8082590 1 rs8082590 chr17:17958402 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.54 -7.02 -0.4 1.86e-11 Schizophrenia; CESC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg13393036 chr8:95962371 TP53INP1 -0.47 -9.81 -0.52 1.38e-19 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06273763 chr15:59664907 MYO1E 0.61 7.33 0.41 2.77e-12 Gut microbiome composition (summer); CESC cis rs4604732 0.631 rs1106721 chr1:247624676 A/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9768139 0.733 rs13225172 chr7:158120334 G/A cg06219351 chr7:158114137 PTPRN2 -0.48 -7.14 -0.4 8.87e-12 Calcium levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27274463 chr12:110338238 TCHP -0.47 -6.56 -0.37 2.82e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10896135 0.526 rs484262 chr11:66399681 C/T cg24851651 chr11:66362959 CCS -0.51 -6.9 -0.39 3.79e-11 Bipolar disorder; CESC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.03 -0.35 5.41e-9 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11662851 chr11:18343665 GTF2H1;HPS5 0.59 6.53 0.37 3.33e-10 Gut microbiome composition (summer); CESC cis rs6430585 0.591 rs309170 chr2:136672775 C/T cg07169764 chr2:136633963 MCM6 1.03 14.65 0.67 5.12e-36 Corneal structure; CESC cis rs12130219 1.000 rs34428306 chr1:152184316 G/C cg25272121 chr1:152190972 HRNR 0.4 5.03 0.3 8.92e-7 Inflammatory skin disease; CESC cis rs7116495 0.609 rs674319 chr11:71775391 T/C cg18441811 chr11:71824068 C11orf51 -0.82 -5.14 -0.3 5.31e-7 Severe influenza A (H1N1) infection; CESC cis rs9815354 1.000 rs9828398 chr3:41895893 C/T cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.48e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs3008870 1.000 rs11208979 chr1:67442275 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.19 -0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs7680126 0.633 rs4697745 chr4:10305081 G/A cg11266682 chr4:10021025 SLC2A9 -0.42 -5.36 -0.31 1.81e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs12142240 0.698 rs41534051 chr1:46828734 A/G cg00530320 chr1:46809349 NSUN4 0.6 7.88 0.44 8.35e-14 Menopause (age at onset); CESC cis rs2072732 0.861 rs12408197 chr1:2951511 C/T cg15211996 chr1:2936768 ACTRT2 0.34 5.95 0.34 8.31e-9 Plateletcrit; CESC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg03605463 chr16:89740564 NA 0.66 7.77 0.43 1.72e-13 Vitiligo; CESC cis rs1413885 0.549 rs9436725 chr1:65852870 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.48 6.32 0.36 1.13e-9 Anticoagulant levels; CESC cis rs12142240 0.698 rs67487250 chr1:46811333 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.29 0.36 1.33e-9 Menopause (age at onset); CESC cis rs7523050 0.730 rs77425121 chr1:109417677 C/A cg08274380 chr1:109419600 GPSM2 0.92 6.41 0.37 6.62e-10 Fat distribution (HIV); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08744727 chr4:206112 ZNF876P -0.61 -6.4 -0.37 7.07e-10 Gut microbiome composition (summer); CESC cis rs9457247 0.602 rs6456152 chr6:167472062 A/G cg23791538 chr6:167370224 RNASET2 -0.52 -6.9 -0.39 3.81e-11 Crohn's disease; CESC cis rs9322193 0.962 rs2275046 chr6:150157001 A/G cg05861140 chr6:150128134 PCMT1 -0.38 -5.34 -0.31 1.96e-7 Lung cancer; CESC cis rs9325144 0.534 rs6582538 chr12:38629997 A/C cg13010199 chr12:38710504 ALG10B -0.42 -5.65 -0.33 4.16e-8 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18421429 chr6:89673507 RNGTT 0.66 7.41 0.41 1.68e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26167861 chr12:16035689 STRAP 0.52 6.73 0.38 1.02e-10 Gut microbiome composition (summer); CESC cis rs113835537 0.877 rs2229455 chr11:66328055 A/G cg24851651 chr11:66362959 CCS 0.54 5.14 0.3 5.23e-7 Airway imaging phenotypes; CESC cis rs1153858 0.621 rs2413769 chr15:45561868 A/C cg21132104 chr15:45694354 SPATA5L1 0.72 8.58 0.47 8.19e-16 Homoarginine levels; CESC trans rs11755845 0.847 rs10948111 chr6:43908624 A/G cg26163234 chr15:99789622 TTC23 -0.43 -6.05 -0.35 4.89e-9 Thyroid hormone levels; CESC cis rs7208859 0.623 rs11651857 chr17:28926362 G/T cg13385521 chr17:29058706 SUZ12P 0.77 5.67 0.33 3.8e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs916888 0.821 rs199505 chr17:44859410 A/G cg17911788 chr17:44343683 NA 0.53 7.06 0.4 1.46e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg06873352 chr17:61820015 STRADA 0.72 12.74 0.62 2.56e-29 Prudent dietary pattern; CESC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg04166393 chr7:2884313 GNA12 0.55 7.0 0.4 2.05e-11 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11141013 chr16:30583056 ZNF688 -0.48 -6.35 -0.36 9.15e-10 Fibrinogen levels; CESC cis rs644799 0.526 rs542509 chr11:95641602 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.53 7.13 0.4 9.7e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22164177 chr12:117013718 MAP1LC3B2 0.44 6.16 0.35 2.64e-9 Fibrinogen levels; CESC cis rs6460942 0.597 rs7811374 chr7:12517437 T/C cg06484146 chr7:12443880 VWDE -0.71 -7.6 -0.42 5.22e-13 Coronary artery disease; CESC cis rs2073300 0.609 rs1076776 chr20:23427399 C/T cg16736954 chr20:23401023 NAPB -0.67 -5.12 -0.3 5.97e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg17545662 chr6:170176663 C6orf70 0.56 7.92 0.44 6.65e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs3096299 0.754 rs3102382 chr16:89409742 C/G cg00750074 chr16:89608354 SPG7 -0.43 -6.3 -0.36 1.22e-9 Multiple myeloma (IgH translocation); CESC cis rs7044106 0.791 rs735109 chr9:123488879 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.72 10.65 0.55 2.85e-22 Hip circumference adjusted for BMI; CESC cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg13175981 chr1:150552382 MCL1 0.68 10.35 0.54 2.67e-21 Tonsillectomy; CESC cis rs1949733 0.666 rs3103070 chr4:8508825 A/G cg11789530 chr4:8429930 ACOX3 -0.7 -9.84 -0.52 1.1e-19 Response to antineoplastic agents; CESC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.6 -7.98 -0.44 4.54e-14 Total body bone mineral density; CESC cis rs4555082 0.718 rs75139030 chr14:105710853 A/AG cg06808227 chr14:105710500 BRF1 -0.51 -5.65 -0.33 4.08e-8 Mean platelet volume;Platelet distribution width; CESC trans rs7246760 0.737 rs60584926 chr19:9797014 C/T cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg26475306 chr20:33999876 UQCC 0.45 6.66 0.38 1.54e-10 Systemic lupus erythematosus; CESC cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg19077165 chr18:44547161 KATNAL2 -0.61 -9.16 -0.49 1.44e-17 Personality dimensions; CESC cis rs1348850 0.914 rs7604673 chr2:178392346 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.87 12.56 0.61 1.04e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6570726 0.935 rs374000 chr6:145855290 C/T cg05347473 chr6:146136440 FBXO30 0.48 6.47 0.37 4.82e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10078 0.559 rs2671891 chr5:456386 A/G cg08916839 chr5:415575 AHRR 0.59 6.81 0.39 6.34e-11 Fat distribution (HIV); CESC cis rs9303401 0.659 rs35082010 chr17:56936867 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.69 0.61 3.78e-29 Cognitive test performance; CESC cis rs11098499 0.863 rs13136462 chr4:120543173 C/T cg24375607 chr4:120327624 NA 0.44 5.46 0.32 1.11e-7 Corneal astigmatism; CESC cis rs10197940 0.624 rs6724796 chr2:152412813 C/T cg19508488 chr2:152266495 RIF1 0.51 5.99 0.35 6.85e-9 Lung cancer; CESC cis rs7772486 0.875 rs12194437 chr6:146411440 A/G cg23711669 chr6:146136114 FBXO30 0.86 12.72 0.62 2.98e-29 Lobe attachment (rater-scored or self-reported); CESC trans rs7836436 0.686 rs7010457 chr8:120955012 A/G cg22699279 chr15:79383890 RASGRF1 -0.7 -6.72 -0.38 1.13e-10 HIV-1 viral setpoint; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13665184 chr16:68057062 DUS2L;DDX28 0.55 6.17 0.35 2.55e-9 Gut microbiome composition (summer); CESC trans rs7726839 0.561 rs4957050 chr5:579066 A/C cg25482853 chr8:67687455 SGK3 0.88 9.47 0.5 1.62e-18 Obesity-related traits; CESC cis rs10489202 1.000 rs7535138 chr1:167931462 T/G cg24449463 chr1:168025552 DCAF6 -0.46 -5.38 -0.31 1.63e-7 Schizophrenia; CESC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg19163074 chr7:65112434 INTS4L2 0.4 5.04 0.3 8.54e-7 Aortic root size; CESC cis rs6088580 0.634 rs6058051 chr20:33044862 G/A cg08999081 chr20:33150536 PIGU 0.66 11.55 0.58 2.83e-25 Glomerular filtration rate (creatinine); CESC cis rs7726839 0.561 rs6555357 chr5:560923 A/G cg09021430 chr5:549028 NA -0.47 -6.36 -0.36 8.68e-10 Obesity-related traits; CESC cis rs16854884 0.609 rs9872126 chr3:143683851 G/A cg06585982 chr3:143692056 C3orf58 0.56 7.58 0.42 5.77e-13 Economic and political preferences (feminism/equality); CESC cis rs9486719 1.000 rs11152959 chr6:96900272 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.21e-15 Migraine;Coronary artery disease; CESC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg15145296 chr3:125709740 NA -0.55 -5.85 -0.34 1.48e-8 Blood pressure (smoking interaction); CESC cis rs5997397 1.000 rs5997397 chr22:29154455 A/G cg02153584 chr22:29168773 CCDC117 0.52 7.17 0.4 7.58e-12 Red cell distribution width; CESC cis rs2228479 0.850 rs11076624 chr16:89855749 T/C cg00800038 chr16:89945340 TCF25 -0.9 -7.5 -0.42 9.55e-13 Skin colour saturation; CESC cis rs10465746 0.935 rs6692233 chr1:84327214 A/G cg10977910 chr1:84465055 TTLL7 -0.46 -6.01 -0.35 6.12e-9 Obesity-related traits; CESC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg07677032 chr17:61819896 STRADA 0.49 6.67 0.38 1.46e-10 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23611233 chr1:249133059 ZNF672 -0.52 -7.06 -0.4 1.42e-11 Fibrinogen levels; CESC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg18099408 chr3:52552593 STAB1 -0.31 -5.2 -0.3 3.94e-7 Bipolar disorder; CESC cis rs3733585 0.699 rs6449172 chr4:9966036 A/T cg11266682 chr4:10021025 SLC2A9 -0.59 -11.12 -0.56 7.83e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4253772 0.637 rs3087501 chr22:46647909 A/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.49 5.18 0.3 4.45e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2014572 0.967 rs8112572 chr19:57759612 T/C cg12963866 chr19:57752005 ZNF805 -0.48 -6.37 -0.36 8.12e-10 Hyperactive-impulsive symptoms; CESC cis rs12956009 0.583 rs4452038 chr18:44856529 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.46 6.17 0.35 2.6e-9 Educational attainment (years of education); CESC cis rs6141600 0.540 rs964786 chr20:34688491 T/C cg07747181 chr20:34652970 NA -0.38 -5.44 -0.32 1.21e-7 Height;Hip circumference; CESC cis rs67478160 0.634 rs2368559 chr14:104230535 C/T cg01849466 chr14:104193079 ZFYVE21 -0.53 -7.73 -0.43 2.26e-13 Schizophrenia; CESC cis rs2415984 0.579 rs28636061 chr14:46959848 T/C cg14871534 chr14:47121158 RPL10L -0.35 -5.38 -0.31 1.6e-7 Number of children ever born; CESC cis rs947211 0.898 rs10900524 chr1:205748309 G/A cg26354017 chr1:205819088 PM20D1 0.44 5.46 0.32 1.1e-7 Parkinson's disease; CESC cis rs1568889 1.000 rs12802830 chr11:28321196 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 8.7 0.47 3.58e-16 Bipolar disorder; CESC cis rs1153858 1.000 rs2114501 chr15:45670316 G/A cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs116095464 0.558 rs55776650 chr5:273826 G/A cg20965017 chr5:231967 SDHA -0.47 -5.3 -0.31 2.46e-7 Breast cancer; CESC cis rs736801 0.521 rs2070729 chr5:131819921 G/T cg21138405 chr5:131827807 IRF1 0.37 6.5 0.37 4e-10 Breast cancer;Mosquito bite size; CESC cis rs4664304 1.000 rs57771571 chr2:160767804 G/C cg03641300 chr2:160917029 PLA2R1 -0.49 -6.94 -0.39 3.06e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg06873352 chr17:61820015 STRADA 0.49 6.84 0.39 5.46e-11 Height; CESC trans rs7702057 0.619 rs7716923 chr5:115700307 A/G cg17756860 chr4:110510374 CCDC109B 0.56 6.2 0.36 2.17e-9 Amyotrophic lateral sclerosis; CESC cis rs4867766 0.789 rs17725606 chr5:173956965 A/C cg20434911 chr5:173954559 NA -0.59 -6.34 -0.36 9.87e-10 Stroke; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg25531986 chr19:53144247 ZNF83 -0.43 -6.28 -0.36 1.41e-9 Asthma; CESC cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg20476274 chr7:133979776 SLC35B4 0.69 10.23 0.53 6.57e-21 Mean platelet volume; CESC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.87 0.44 9.29e-14 Menopause (age at onset); CESC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.91 0.34 1.06e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9486715 0.867 rs9486444 chr6:96963619 A/G cg18709589 chr6:96969512 KIAA0776 0.45 6.24 0.36 1.76e-9 Headache; CESC cis rs703842 0.964 rs10431552 chr12:58178148 G/A cg18357645 chr12:58087776 OS9 -0.4 -5.62 -0.33 4.76e-8 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22966060 chr19:5686806 HSD11B1L -0.56 -6.3 -0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs4129585 1.000 rs4129585 chr8:143312933 A/C cg16886403 chr8:143471632 TSNARE1 0.45 5.68 0.33 3.49e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC trans rs7618501 0.633 rs6772095 chr3:49978069 C/T cg21659725 chr3:3221576 CRBN 0.55 7.6 0.42 5.29e-13 Intelligence (multi-trait analysis); CESC cis rs10771431 0.597 rs10771412 chr12:9354353 A/C cg08997352 chr12:9597637 DDX12 -0.71 -8.82 -0.48 1.57e-16 Breast size; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg19219231 chr2:61108086 REL 0.48 6.22 0.36 1.93e-9 Attention deficit hyperactivity disorder; CESC cis rs9291683 0.530 rs4235346 chr4:9945296 C/T cg00071950 chr4:10020882 SLC2A9 -0.8 -14.84 -0.67 1.1e-36 Bone mineral density; CESC cis rs3733585 0.699 rs28610447 chr4:9971517 T/C cg11266682 chr4:10021025 SLC2A9 -0.58 -10.87 -0.56 5.3e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10887741 0.646 rs7903568 chr10:89433931 T/A cg13926569 chr10:89418898 PAPSS2 0.46 6.89 0.39 4.15e-11 Exercise (leisure time); CESC cis rs6987853 0.761 rs2923391 chr8:42415942 G/A cg09913449 chr8:42400586 C8orf40 0.45 7.44 0.42 1.39e-12 Mean corpuscular hemoglobin concentration; CESC trans rs747782 0.528 rs11039674 chr11:48336116 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.31 0.36 1.19e-9 Intraocular pressure; CESC cis rs3820068 0.705 rs11589076 chr1:15827027 C/T cg17385448 chr1:15911702 AGMAT 0.4 6.14 0.35 3.04e-9 Systolic blood pressure; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23100370 chr2:109336342 RANBP2 -0.49 -6.5 -0.37 3.97e-10 Ulcerative colitis; CESC cis rs7216064 1.000 rs62084246 chr17:65867911 G/C cg12091567 chr17:66097778 LOC651250 -0.85 -8.7 -0.47 3.61e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg07859478 chr19:808116 PTBP1 -0.48 -6.2 -0.36 2.21e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs3892630 0.818 rs80137870 chr19:33182750 C/T cg22980127 chr19:33182716 NUDT19 1.02 11.74 0.58 6.86e-26 Red blood cell traits; CESC cis rs2777491 1.000 rs316613 chr15:41747598 G/A cg02330683 chr15:41787940 ITPKA 0.47 6.95 0.39 2.9e-11 Ulcerative colitis; CESC cis rs6815814 0.808 rs11721824 chr4:38767749 G/A cg02016764 chr4:38805732 TLR1 -0.69 -7.48 -0.42 1.06e-12 Breast cancer; CESC cis rs6831352 0.879 rs29001215 chr4:100051722 T/C cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs7267979 1.000 rs2258879 chr20:25279213 T/C cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs889312 0.521 rs12651942 chr5:56088484 C/T cg14703610 chr5:56206110 C5orf35 0.46 6.07 0.35 4.3e-9 Breast cancer;Breast cancer (early onset); CESC cis rs561341 0.739 rs7213369 chr17:30211878 G/A cg13647721 chr17:30228624 UTP6 -0.76 -9.3 -0.5 5.52e-18 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.89 0.44 7.83e-14 Prudent dietary pattern; CESC cis rs2072732 0.904 rs9660819 chr1:2952823 C/T cg03976712 chr1:2946727 NA 0.33 5.45 0.32 1.17e-7 Plateletcrit; CESC cis rs9902453 1.000 rs56280226 chr17:28429575 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 7.99 0.44 4.06e-14 Coffee consumption (cups per day); CESC cis rs611744 0.608 rs667742 chr8:109254003 T/C cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.65e-8 Dupuytren's disease; CESC cis rs763121 0.853 rs1065201 chr22:39069510 T/C cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC cis rs12530845 0.887 rs6948382 chr7:135323576 G/A cg23117316 chr7:135346802 PL-5283 -0.47 -5.76 -0.33 2.33e-8 Red blood cell traits; CESC cis rs7940866 0.845 rs1433976 chr11:130875123 C/T cg12179176 chr11:130786555 SNX19 -0.61 -8.37 -0.46 3.35e-15 Schizophrenia; CESC cis rs7819412 0.745 rs7017567 chr8:10933699 T/A cg21775007 chr8:11205619 TDH -0.43 -5.94 -0.34 9e-9 Triglycerides; CESC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.6 -0.42 4.99e-13 Gut microbiome composition (summer); CESC cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg12923728 chr3:195709715 SDHAP1 -0.67 -8.99 -0.48 4.91e-17 Pancreatic cancer; CESC cis rs7586673 0.893 rs889925 chr2:161971597 T/C cg22496339 chr2:162101262 NA 0.49 6.51 0.37 3.64e-10 Intelligence (multi-trait analysis); CESC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg06634786 chr22:41940651 POLR3H -0.6 -6.61 -0.38 2.07e-10 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09535750 chr10:122702484 NA -0.55 -6.27 -0.36 1.44e-9 Gut microbiome composition (summer); CESC cis rs796364 0.906 rs281784 chr2:200749749 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.86 8.18 0.45 1.19e-14 Schizophrenia; CESC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg23978390 chr7:1156363 C7orf50 0.65 9.17 0.49 1.37e-17 Longevity;Endometriosis; CESC cis rs8070740 1.000 rs8070740 chr17:5331896 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.56 6.77 0.38 8.23e-11 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19257979 chr20:37101387 RALGAPB 0.59 6.67 0.38 1.49e-10 Gut microbiome composition (summer); CESC cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg02880119 chr16:3481970 NA 0.4 5.08 0.3 7.26e-7 Body mass index (adult); CESC cis rs6460942 1.000 rs2033871 chr7:12405098 C/A cg20607287 chr7:12443886 VWDE -0.68 -7.91 -0.44 6.85e-14 Coronary artery disease; CESC cis rs8062405 0.755 rs4788080 chr16:28558081 C/T cg07382826 chr16:28625726 SULT1A1 0.4 6.69 0.38 1.3e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg07677032 chr17:61819896 STRADA -0.45 -5.99 -0.35 6.94e-9 Prudent dietary pattern; CESC cis rs873946 0.689 rs2803993 chr10:134550606 T/C cg06453172 chr10:134556979 INPP5A -0.38 -5.13 -0.3 5.55e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9902453 0.765 rs6505143 chr17:28150585 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.24 0.53 5.98e-21 Coffee consumption (cups per day); CESC cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg18527119 chr7:66119851 NA -0.45 -5.14 -0.3 5.4e-7 Aortic root size; CESC cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg12292205 chr6:26970375 C6orf41 -0.55 -5.96 -0.34 7.88e-9 Intelligence (multi-trait analysis); CESC cis rs4253772 0.550 rs9615951 chr22:46728056 C/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 5.88 0.34 1.21e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6580649 0.941 rs57380031 chr12:48452237 C/T cg24011408 chr12:48396354 COL2A1 -0.42 -5.28 -0.31 2.67e-7 Lung cancer; CESC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg25427524 chr10:38739819 LOC399744 0.65 9.3 0.5 5.35e-18 Extrinsic epigenetic age acceleration; CESC cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg01475377 chr6:109611718 NA 0.52 8.64 0.47 5.22e-16 Reticulocyte fraction of red cells; CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg22907277 chr7:1156413 C7orf50 0.45 6.52 0.37 3.54e-10 Longevity;Endometriosis; CESC cis rs78889164 0.955 rs78042672 chr19:33848695 C/A cg02272751 chr19:33882848 PEPD -0.51 -6.6 -0.38 2.26e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs950169 0.960 rs12905475 chr15:84800495 G/A cg17507749 chr15:85114479 UBE2QP1 0.6 6.56 0.37 2.82e-10 Schizophrenia; CESC cis rs9581857 0.579 rs2780341 chr13:27996401 C/T cg01674679 chr13:27998804 GTF3A 0.67 5.59 0.32 5.75e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs13106227 0.550 rs1849215 chr4:77377449 T/C cg20311846 chr4:77356250 SHROOM3 -0.31 -5.67 -0.33 3.65e-8 Eosinophilic esophagitis (pediatric); CESC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.26 -0.53 5.05e-21 Alzheimer's disease; CESC cis rs2439831 0.867 rs3213991 chr15:43670280 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.86 13.09 0.63 1.57e-30 Lung cancer in ever smokers; CESC cis rs9611565 0.918 rs6002351 chr22:41757223 C/T cg03806693 chr22:41940476 POLR3H -0.74 -8.96 -0.48 5.97e-17 Vitiligo; CESC cis rs8180040 0.627 rs58956475 chr3:47224615 G/C cg27129171 chr3:47204927 SETD2 -0.67 -9.83 -0.52 1.2e-19 Colorectal cancer; CESC cis rs6964587 0.967 rs7788092 chr7:91646198 C/T cg17063962 chr7:91808500 NA 0.55 7.63 0.42 4.25e-13 Breast cancer; CESC cis rs911555 0.655 rs10141157 chr14:104018105 T/C cg12935359 chr14:103987150 CKB -0.4 -5.52 -0.32 8.15e-8 Intelligence (multi-trait analysis); CESC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg10691866 chr7:65817282 TPST1 -0.35 -5.77 -0.33 2.18e-8 Aortic root size; CESC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3820928 0.904 rs6735069 chr2:227893660 A/G cg11843606 chr2:227700838 RHBDD1 -0.48 -6.2 -0.36 2.12e-9 Pulmonary function; CESC cis rs4566357 1.000 rs6705783 chr2:227923268 C/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.25 -0.31 3.09e-7 Coronary artery disease; CESC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg07701084 chr6:150067640 NUP43 0.49 6.73 0.38 1.07e-10 Lung cancer; CESC cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg19717773 chr7:2847554 GNA12 -0.49 -7.34 -0.41 2.58e-12 Height; CESC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.61 0.38 2.15e-10 Bipolar disorder; CESC trans rs208520 1.000 rs12216109 chr6:66987488 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.34 0.5 4.23e-18 Exhaled nitric oxide output; CESC cis rs6460942 1.000 rs79964328 chr7:12319392 A/C cg02935154 chr7:12443704 VWDE -0.59 -5.84 -0.34 1.5e-8 Coronary artery disease; CESC cis rs34375054 0.558 rs12578774 chr12:125681761 A/G cg25124228 chr12:125621409 AACS 0.47 5.61 0.33 5.11e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs3540 0.574 rs2657946 chr15:90967513 G/C cg10434728 chr15:90938212 IQGAP1 0.42 7.35 0.41 2.41e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs8005677 0.962 rs8003934 chr14:23401142 A/G cg25600027 chr14:23388339 RBM23 -0.43 -5.24 -0.31 3.22e-7 Cognitive ability (multi-trait analysis); CESC cis rs863345 0.967 rs10797014 chr1:158468202 C/T cg12129480 chr1:158549410 OR10X1 -0.31 -6.23 -0.36 1.78e-9 Pneumococcal bacteremia; CESC cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg22834771 chr12:69754056 YEATS4 -0.55 -7.29 -0.41 3.61e-12 Cerebrospinal fluid biomarker levels; CESC cis rs644799 0.763 rs2950521 chr11:95536870 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.91 13.69 0.64 1.25e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs12545109 0.959 rs12546307 chr8:57314790 T/A cg09654669 chr8:57350985 NA -0.58 -6.97 -0.39 2.44e-11 Obesity-related traits; CESC cis rs17253792 0.822 rs76557162 chr14:56064701 A/G cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg05283184 chr6:79620031 NA -0.44 -6.79 -0.39 7.19e-11 Intelligence (multi-trait analysis); CESC cis rs7568458 0.709 rs2592551 chr2:85780131 G/A cg02493740 chr2:85810744 VAMP5 -0.57 -8.42 -0.46 2.41e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs72781680 1.000 rs72781689 chr2:24256349 C/T cg08917208 chr2:24149416 ATAD2B 1.07 8.78 0.47 2.02e-16 Lymphocyte counts; CESC cis rs9815354 0.812 rs59138513 chr3:41908611 T/G cg03022575 chr3:42003672 ULK4 0.7 6.18 0.36 2.38e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs561341 0.882 rs28649357 chr17:30367190 A/G cg27661571 chr11:113659931 NA -0.6 -6.12 -0.35 3.28e-9 Hip circumference adjusted for BMI; CESC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.67 0.47 4.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Parkinson's disease; CESC cis rs3859192 0.561 rs12453343 chr17:38181176 C/A cg17467752 chr17:38218738 THRA -0.47 -6.34 -0.36 9.92e-10 White blood cell count; CESC cis rs10088262 0.629 rs9918907 chr8:124816862 A/G cg02993010 chr8:124780839 FAM91A1 -0.65 -8.15 -0.45 1.47e-14 Pancreatic cancer; CESC cis rs9911578 0.900 rs7214335 chr17:57158840 G/A cg12560992 chr17:57184187 TRIM37 0.94 15.69 0.69 1.11e-39 Intelligence (multi-trait analysis); CESC cis rs36051895 0.623 rs6476955 chr9:5256533 C/G cg02405213 chr9:5042618 JAK2 -0.49 -5.94 -0.34 9.08e-9 Pediatric autoimmune diseases; CESC cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg18350739 chr11:68623251 NA -0.45 -6.96 -0.39 2.67e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2066819 1.000 rs59626664 chr12:56636975 C/G cg26714650 chr12:56694279 CS -1.42 -10.05 -0.53 2.39e-20 Psoriasis vulgaris; CESC cis rs67478160 0.619 rs28698555 chr14:104316486 C/A cg08213375 chr14:104286397 PPP1R13B -0.54 -10.59 -0.55 4.43e-22 Schizophrenia; CESC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg23758822 chr17:41437982 NA 0.97 16.05 0.7 5.97e-41 Menopause (age at onset); CESC trans rs637571 0.544 rs12361552 chr11:65701204 G/A cg17712092 chr4:129076599 LARP1B -0.68 -8.74 -0.47 2.67e-16 Eosinophil percentage of white cells; CESC cis rs5753618 0.583 rs9606839 chr22:31802710 A/C cg00478049 chr22:31556069 RNF185 -0.42 -5.03 -0.3 8.97e-7 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27193691 chr11:568206 MIR210 0.53 6.26 0.36 1.57e-9 Gut microbiome composition (summer); CESC cis rs35740288 0.520 rs56183577 chr15:86319706 A/G cg20737812 chr15:86336631 KLHL25 -0.46 -5.41 -0.32 1.42e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs7000551 0.751 rs2469775 chr8:22373238 T/C cg12081754 chr8:22256438 SLC39A14 0.4 5.4 0.32 1.45e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC trans rs7751419 0.527 rs4714216 chr6:39106207 G/A cg14065446 chr9:133818825 NA 0.36 6.92 0.39 3.45e-11 Cardiovascular disease in hypertension (calcium channel blocker interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13196216 chr6:34231128 NA -0.61 -6.75 -0.38 9.23e-11 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24023618 chr6:114292459 HDAC2 0.54 7.13 0.4 9.63e-12 Gut microbiota (bacterial taxa); CESC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg09509183 chr1:209979624 IRF6 0.56 5.68 0.33 3.47e-8 Cleft lip with or without cleft palate; CESC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -7.47 -0.42 1.2e-12 Developmental language disorder (linguistic errors); CESC cis rs72901758 0.768 rs11655421 chr17:76251518 T/A cg26068271 chr17:76253126 NA 0.47 6.64 0.38 1.76e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs10788309 0.506 rs12359165 chr10:85821884 C/T cg03623264 chr10:85672087 NA -0.41 -5.83 -0.34 1.64e-8 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); CESC cis rs561341 0.739 rs4795663 chr17:30214542 T/C cg13647721 chr17:30228624 UTP6 -0.79 -10.09 -0.53 1.87e-20 Hip circumference adjusted for BMI; CESC cis rs8180040 0.647 rs57756484 chr3:47239333 A/G cg27129171 chr3:47204927 SETD2 -0.66 -9.64 -0.51 4.74e-19 Colorectal cancer; CESC cis rs6062302 0.522 rs3810492 chr20:62219740 G/A cg06363034 chr20:62225388 GMEB2 -0.5 -6.35 -0.36 9.21e-10 Glioblastoma; CESC cis rs1983170 1.000 rs1983170 chr1:91986482 G/A cg02896835 chr1:92012615 NA 0.56 6.43 0.37 6.04e-10 Eosinophil percentage of white cells; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22708233 chr11:47198576 ARFGAP2 -0.44 -6.21 -0.36 2.08e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10883723 0.738 rs3781290 chr10:104244948 G/C cg22532475 chr10:104410764 TRIM8 -0.33 -5.64 -0.33 4.32e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs11864453 0.826 rs8062041 chr16:72088964 C/T cg23815491 chr16:72088622 HP 0.37 5.07 0.3 7.58e-7 Fibrinogen levels; CESC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg08859206 chr1:53392774 SCP2 0.53 7.09 0.4 1.19e-11 Monocyte count; CESC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg23758822 chr17:41437982 NA 1.03 15.62 0.69 2.01e-39 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15278734 chr4:147443742 SLC10A7 0.63 7.01 0.4 2e-11 Gut microbiome composition (summer); CESC cis rs7264396 0.790 rs6121015 chr20:34243017 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.74 -0.58 6.79e-26 Total cholesterol levels; CESC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg02725872 chr8:58115012 NA -0.45 -7.02 -0.4 1.83e-11 Developmental language disorder (linguistic errors); CESC cis rs2242116 0.796 rs7623898 chr3:46974172 C/T cg02527881 chr3:46936655 PTH1R 0.51 7.18 0.4 7.14e-12 Birth weight; CESC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.57 0.64 3.36e-32 Prudent dietary pattern; CESC cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg05457628 chr5:178986728 RUFY1 0.46 6.5 0.37 3.88e-10 Lung cancer; CESC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg18825119 chr6:163149453 PACRG;PARK2 0.54 5.2 0.3 4.01e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9815354 0.812 rs11129932 chr3:41838767 C/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs62229266 0.626 rs7280896 chr21:37460906 G/A cg12218747 chr21:37451666 NA -0.51 -7.7 -0.43 2.67e-13 Mitral valve prolapse; CESC cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.28e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6025261 0.874 rs454279 chr20:55513949 C/T cg04763273 chr20:55502381 NA 0.31 5.27 0.31 2.88e-7 Verbal memory performance (delayed recall level); CESC cis rs864537 0.618 rs1214595 chr1:167427557 G/A cg22356347 chr1:167427500 CD247 -0.41 -8.43 -0.46 2.18e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg27266027 chr21:40555129 PSMG1 0.43 5.09 0.3 6.68e-7 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05792856 chr11:34379731 ABTB2 0.61 6.9 0.39 3.74e-11 Gut microbiome composition (summer); CESC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg25767906 chr1:53392781 SCP2 -0.48 -6.4 -0.37 7.01e-10 Monocyte count; CESC cis rs17345786 0.861 rs79181492 chr3:101216021 G/A cg12386194 chr3:101231763 SENP7 0.61 6.4 0.37 7.01e-10 Colonoscopy-negative controls vs population controls; CESC cis rs8072100 0.539 rs36043200 chr17:45629406 G/A cg08085267 chr17:45401833 C17orf57 0.45 5.9 0.34 1.11e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs17293817 0.618 rs56117517 chr10:1430552 A/C cg04271617 chr10:1416546 ADARB2 0.33 5.03 0.3 9.18e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg19592336 chr6:28129416 ZNF389 0.44 6.34 0.36 9.85e-10 Parkinson's disease; CESC cis rs1008375 0.900 rs4698622 chr4:17589557 C/T cg02297831 chr4:17616191 MED28 0.53 6.06 0.35 4.58e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs4332037 0.539 rs11763750 chr7:2080114 G/A cg11693508 chr17:37793320 STARD3 0.61 6.11 0.35 3.54e-9 Bipolar disorder; CESC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.04 0.3 8.79e-7 Bipolar disorder; CESC cis rs854765 0.583 rs8070722 chr17:17813562 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.25 0.41 4.49e-12 Total body bone mineral density; CESC trans rs2235573 0.527 rs139883 chr22:38369027 C/T cg19894588 chr14:64061835 NA 0.57 7.43 0.42 1.5e-12 Glioblastoma;Glioma; CESC cis rs6964587 0.732 rs12539523 chr7:91710836 G/A cg17063962 chr7:91808500 NA 0.55 7.46 0.42 1.26e-12 Breast cancer; CESC cis rs1832871 0.711 rs76962726 chr6:158674041 C/T cg07165851 chr6:158734300 TULP4 0.59 6.26 0.36 1.5e-9 Height; CESC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg11764359 chr7:65958608 NA 0.79 9.37 0.5 3.25e-18 Aortic root size; CESC cis rs2795502 1.000 rs2796575 chr10:43374911 A/G cg27426351 chr10:43362370 NA 0.5 6.18 0.36 2.35e-9 Blood protein levels; CESC cis rs6580649 0.943 rs3803183 chr12:48398080 T/A cg24011408 chr12:48396354 COL2A1 0.4 5.24 0.31 3.22e-7 Lung cancer; CESC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs4423214 0.840 rs1790339 chr11:71182761 C/A cg05163923 chr11:71159392 DHCR7 -0.68 -7.76 -0.43 1.82e-13 Vitamin D levels; CESC cis rs734999 0.545 rs12749591 chr1:2563250 G/T cg18854424 chr1:2615690 NA -0.29 -5.92 -0.34 1e-8 Ulcerative colitis; CESC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg11890956 chr21:40555474 PSMG1 1.2 22.3 0.81 9.49e-63 Cognitive function; CESC cis rs10771431 0.713 rs17794353 chr12:9361783 C/T cg00504896 chr12:9437009 LOC642846 0.38 5.13 0.3 5.65e-7 Breast size; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg01353569 chr7:106810328 HBP1 0.48 6.47 0.37 4.81e-10 Systemic lupus erythematosus; CESC cis rs9399137 0.507 rs7754722 chr6:135260303 T/C cg24558204 chr6:135376177 HBS1L -0.7 -9.45 -0.5 1.91e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg04944784 chr2:26401820 FAM59B 0.93 10.63 0.55 3.17e-22 Gut microbiome composition (summer); CESC cis rs79349575 0.783 rs4793992 chr17:47008207 A/G cg26022315 chr17:47021804 SNF8 0.39 5.15 0.3 5.04e-7 Type 2 diabetes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23539498 chr22:35654203 HMGXB4 -0.46 -6.55 -0.37 2.89e-10 Asthma; CESC cis rs5758511 0.680 rs739146 chr22:42660414 A/G cg00645731 chr22:42541494 CYP2D7P1 0.57 8.69 0.47 3.84e-16 Birth weight; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18772858 chr7:2296703 SNX8 -0.59 -6.53 -0.37 3.25e-10 Gut microbiome composition (summer); CESC cis rs763014 0.833 rs3743902 chr16:632728 T/C cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.35e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs637571 0.522 rs12797319 chr11:65735672 G/A cg17712092 chr4:129076599 LARP1B 0.75 10.36 0.54 2.39e-21 Eosinophil percentage of white cells; CESC cis rs4642101 0.793 rs6763619 chr3:12822147 T/G cg24848339 chr3:12840334 CAND2 0.39 5.96 0.34 8.16e-9 QRS complex (12-leadsum); CESC cis rs753778 0.667 rs10092439 chr8:142210881 C/T cg18755752 chr8:142205143 DENND3 -0.68 -10.04 -0.53 2.54e-20 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs983392 0.679 rs7128450 chr11:60031270 G/C cg13921652 chr1:144931966 PDE4DIP 0.48 6.15 0.35 2.91e-9 Alzheimer's disease (late onset); CESC cis rs9916302 0.904 rs34363096 chr17:37594294 G/A cg07936489 chr17:37558343 FBXL20 -0.8 -11.5 -0.58 4.2e-25 Glomerular filtration rate (creatinine); CESC trans rs875971 0.660 rs62465434 chr7:66005152 A/C cg26939375 chr7:64535504 NA 0.63 8.63 0.47 5.93e-16 Aortic root size; CESC cis rs6714710 0.603 rs13008968 chr2:98435982 C/T cg26665480 chr2:98280029 ACTR1B 0.6 8.4 0.46 2.67e-15 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs11153306 1.000 rs17703931 chr6:111950995 C/T cg22127309 chr6:111907043 TRAF3IP2 0.36 5.44 0.32 1.18e-7 Tonsillectomy; CESC cis rs7647973 0.626 rs9824435 chr3:49674343 A/G cg13072238 chr3:49761600 GMPPB 0.51 5.78 0.33 2.14e-8 Menarche (age at onset); CESC cis rs200367988 1 rs200367988 chr10:122674849 G/A cg14149699 chr10:122610679 WDR11 -0.48 -7.1 -0.4 1.14e-11 Prostate-specific antigen levels (conditioned on lead SNPs);Prostate-specific antigen levels; CESC cis rs34779708 0.966 rs35079558 chr10:35479886 A/G cg04310649 chr10:35416472 CREM -0.5 -5.94 -0.34 8.97e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9399401 0.961 rs9403381 chr6:142661156 A/C cg03128060 chr6:142623767 GPR126 -0.26 -5.17 -0.3 4.53e-7 Chronic obstructive pulmonary disease; CESC cis rs9858542 1.000 rs9823546 chr3:49705512 T/A cg07274523 chr3:49395745 GPX1 0.65 8.36 0.46 3.58e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7618501 0.966 rs2352974 chr3:49890613 C/T cg24308560 chr3:49941425 MST1R -0.47 -6.13 -0.35 3.14e-9 Intelligence (multi-trait analysis); CESC cis rs9650657 0.530 rs6982381 chr8:10952500 A/T cg21775007 chr8:11205619 TDH -0.36 -5.04 -0.3 8.76e-7 Neuroticism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04179819 chr10:7860513 TAF3 -0.47 -6.35 -0.36 9.29e-10 Ulcerative colitis; CESC cis rs2832077 0.527 rs2738953 chr21:30238363 G/C cg24692254 chr21:30365293 RNF160 0.53 6.9 0.39 3.79e-11 Cognitive test performance; CESC cis rs34172651 0.917 rs17771137 chr16:24792242 G/A cg06028605 chr16:24865363 SLC5A11 0.41 6.22 0.36 1.94e-9 Intelligence (multi-trait analysis); CESC cis rs4474465 0.850 rs4245460 chr11:78258147 G/C cg02023728 chr11:77925099 USP35 -0.39 -5.14 -0.3 5.25e-7 Alzheimer's disease (survival time); CESC cis rs4974559 0.739 rs3817604 chr4:1291337 C/T cg02980000 chr4:1222292 CTBP1 0.8 7.12 0.4 1.02e-11 Systolic blood pressure; CESC cis rs6582630 0.555 rs7965311 chr12:38513307 G/A cg26384229 chr12:38710491 ALG10B -0.65 -9.76 -0.51 1.94e-19 Drug-induced liver injury (flucloxacillin); CESC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg23281280 chr6:28129359 ZNF389 0.56 7.61 0.42 4.93e-13 Depression; CESC cis rs4835473 0.832 rs62337616 chr4:144658460 A/C cg25736465 chr4:144833511 NA -0.33 -5.25 -0.31 3.1e-7 Immature fraction of reticulocytes; CESC cis rs3806843 0.966 rs2240693 chr5:140183325 G/C cg26395211 chr5:140044315 WDR55 -0.42 -5.33 -0.31 2.07e-7 Depressive symptoms (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23112213 chr5:137549144 CDC23 0.43 6.11 0.35 3.5e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3749237 0.615 rs55957735 chr3:49438158 G/A cg02487422 chr3:49467188 NICN1 0.55 7.99 0.44 4.23e-14 Resting heart rate; CESC cis rs7692995 1.000 rs7671110 chr4:17874089 C/T cg08925142 chr4:18023851 LCORL -0.46 -5.26 -0.31 3e-7 Height; CESC cis rs760805 1.000 rs10903115 chr1:25261696 A/G cg22509179 chr1:25234806 RUNX3 -0.63 -9.41 -0.5 2.44e-18 Allergic disease (asthma, hay fever or eczema); CESC trans rs61931739 0.500 rs7306334 chr12:34482900 A/G cg26384229 chr12:38710491 ALG10B -0.71 -10.7 -0.55 1.85e-22 Morning vs. evening chronotype; CESC cis rs17666538 0.585 rs4333567 chr8:636611 C/T cg07234876 chr8:600039 NA 0.86 5.3 0.31 2.49e-7 IgG glycosylation; CESC cis rs2072732 0.861 rs12041583 chr1:2950886 A/G cg03976712 chr1:2946727 NA 0.33 5.45 0.32 1.17e-7 Plateletcrit; CESC cis rs11098499 0.954 rs71614438 chr4:120371252 G/A cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs3947 1.000 rs3947 chr8:11702375 G/A cg00262122 chr8:11665843 FDFT1 -0.5 -5.12 -0.3 5.8e-7 Blood protein levels; CESC cis rs793571 0.536 rs7183336 chr15:58966236 C/T cg05156742 chr15:59063176 FAM63B 0.58 7.19 0.4 6.73e-12 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08854560 chr22:38453474 PICK1 0.57 6.14 0.35 2.99e-9 Gut microbiome composition (summer); CESC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg18876405 chr7:65276391 NA -0.54 -7.57 -0.42 6.03e-13 Aortic root size; CESC trans rs6089829 0.926 rs6062395 chr20:61667904 A/G cg23505145 chr19:12996616 KLF1 0.51 6.68 0.38 1.37e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg21395723 chr22:39101663 GTPBP1 -0.41 -5.09 -0.3 6.79e-7 Menopause (age at onset); CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg22605924 chr3:168526498 C3orf50 0.39 6.18 0.35 2.47e-9 Prevalent atrial fibrillation; CESC cis rs938554 0.577 rs4591605 chr4:10002719 T/C cg11266682 chr4:10021025 SLC2A9 0.45 6.21 0.36 2.07e-9 Blood metabolite levels; CESC cis rs4629710 0.592 rs9492865 chr6:131534403 T/A cg12606694 chr6:131520996 AKAP7 0.47 5.77 0.33 2.2e-8 Multiple myeloma (IgH translocation); CESC cis rs2274273 0.840 rs6573020 chr14:55871452 C/T cg04306507 chr14:55594613 LGALS3 0.27 5.4 0.31 1.51e-7 Protein biomarker; CESC cis rs748404 0.578 rs478028 chr15:43610772 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.6 8.0 0.44 3.9e-14 Lung cancer; CESC cis rs1348850 0.914 rs3902850 chr2:178315899 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.88 12.77 0.62 2e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg09658497 chr7:2847517 GNA12 -0.43 -6.09 -0.35 4.05e-9 Height; CESC cis rs36051895 0.632 rs12352285 chr9:5141476 C/G cg02405213 chr9:5042618 JAK2 -0.49 -6.21 -0.36 2.09e-9 Pediatric autoimmune diseases; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24833071 chr7:75115655 POM121C -0.46 -6.21 -0.36 2.06e-9 Fibrinogen levels; CESC cis rs34172651 0.571 rs9922156 chr16:24704329 C/A cg06505273 chr16:24850292 NA -0.45 -5.56 -0.32 6.46e-8 Intelligence (multi-trait analysis); CESC cis rs9287719 0.839 rs7600695 chr2:10739945 A/G cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC trans rs1814175 0.754 rs7103235 chr11:49699191 A/G cg03929089 chr4:120376271 NA -0.76 -10.19 -0.53 8.33e-21 Height; CESC cis rs4919694 1.000 rs111622998 chr10:104953021 C/A cg04362960 chr10:104952993 NT5C2 0.85 7.39 0.41 1.91e-12 Arsenic metabolism; CESC cis rs2415984 0.562 rs1494092 chr14:46970304 T/C cg14871534 chr14:47121158 RPL10L 0.4 5.62 0.33 4.94e-8 Number of children ever born; CESC cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg02487422 chr3:49467188 NICN1 0.48 6.16 0.35 2.75e-9 Parkinson's disease; CESC cis rs11608355 0.515 rs12826754 chr12:109923244 A/G cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9902453 0.780 rs3115093 chr17:28039755 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.12 0.53 1.41e-20 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06747916 chr17:57784835 TMEM49;PTRH2 0.63 7.05 0.4 1.59e-11 Gut microbiome composition (summer); CESC cis rs72781680 0.898 rs72786298 chr2:24083011 C/T cg20701182 chr2:24300061 SF3B14 0.79 6.89 0.39 4.15e-11 Lymphocyte counts; CESC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg06873352 chr17:61820015 STRADA 0.72 12.56 0.61 1.02e-28 Prudent dietary pattern; CESC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs2204008 0.713 rs2320522 chr12:38251438 C/T cg13010199 chr12:38710504 ALG10B 0.52 6.38 0.36 8.04e-10 Bladder cancer; CESC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg07870213 chr5:140052090 DND1 -0.61 -6.89 -0.39 4.01e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs300703 0.542 rs300696 chr2:183330 G/A cg21211680 chr2:198530 NA -0.85 -9.2 -0.49 1.08e-17 Blood protein levels; CESC cis rs9300255 0.602 rs1790116 chr12:123618544 G/T cg00376283 chr12:123451042 ABCB9 0.69 8.67 0.47 4.33e-16 Neutrophil percentage of white cells; CESC cis rs1801251 0.685 rs1515961 chr2:233623763 C/A cg08000102 chr2:233561755 GIGYF2 0.66 9.78 0.51 1.79e-19 Coronary artery disease; CESC cis rs10851478 0.872 rs1948975 chr15:49984805 C/A cg08060515 chr15:49448048 GALK2;COPS2 0.44 5.24 0.31 3.22e-7 Oral cavity cancer; CESC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg09359103 chr1:154839909 KCNN3 -0.63 -11.19 -0.57 4.58e-24 Prostate cancer; CESC cis rs9905704 0.846 rs28363318 chr17:56798207 T/C cg12560992 chr17:57184187 TRIM37 0.62 7.78 0.43 1.6e-13 Testicular germ cell tumor; CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.64 0.33 4.27e-8 Electroencephalogram traits; CESC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg27266027 chr21:40555129 PSMG1 0.47 5.36 0.31 1.84e-7 Cognitive function; CESC cis rs7618501 1.000 rs1049256 chr3:49763338 T/C cg24308560 chr3:49941425 MST1R 0.5 6.81 0.39 6.39e-11 Intelligence (multi-trait analysis); CESC cis rs116095464 0.558 rs62346526 chr5:220614 T/C cg22857025 chr5:266934 NA -1.27 -18.89 -0.76 5.51e-51 Breast cancer; CESC cis rs4253772 0.513 rs6008700 chr22:46722560 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.78 9.29 0.5 5.98e-18 LDL cholesterol;Cholesterol, total; CESC cis rs9300255 0.537 rs1727334 chr12:123714236 A/G cg19016782 chr12:123741754 C12orf65 -0.5 -7.08 -0.4 1.33e-11 Neutrophil percentage of white cells; CESC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg23281280 chr6:28129359 ZNF389 0.45 6.18 0.35 2.39e-9 Parkinson's disease; CESC cis rs5769765 1.000 rs5770728 chr22:50259984 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.45 5.26 0.31 2.9e-7 Schizophrenia; CESC cis rs7605827 0.930 rs1015835 chr2:15625768 T/C cg19274914 chr2:15703543 NA 0.36 6.41 0.37 6.6e-10 Educational attainment (years of education); CESC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.8 0.55 8.72e-23 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22804502 chr6:7389831 CAGE1;RIOK1 0.56 6.46 0.37 4.91e-10 Gut microbiome composition (summer); CESC cis rs2985684 0.894 rs4581611 chr14:50043520 A/T cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.43 -5.21 -0.3 3.82e-7 Carotid intima media thickness; CESC trans rs12339966 0.689 rs2586344 chr9:11677296 A/G cg03904639 chr13:37677730 CSNK1A1L 0.39 6.06 0.35 4.67e-9 Systolic blood pressure; CESC cis rs2243480 0.901 rs35823062 chr7:65965821 A/G cg12463550 chr7:65579703 CRCP 0.71 5.51 0.32 8.58e-8 Diabetic kidney disease; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg11199428 chr13:52027379 INTS6 -0.43 -6.21 -0.36 2.02e-9 Breast cancer; CESC cis rs459482 1.000 rs464783 chr21:42796480 A/G cg14166395 chr21:42792516 MX1 -0.57 -7.41 -0.41 1.68e-12 IgG glycosylation; CESC cis rs6963495 0.585 rs1728653 chr7:105191335 A/G cg19920283 chr7:105172520 RINT1 0.61 7.08 0.4 1.29e-11 Bipolar disorder (body mass index interaction); CESC cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg23711669 chr6:146136114 FBXO30 0.93 12.22 0.6 1.57e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs7824557 0.510 rs1435274 chr8:11235910 G/A cg06636001 chr8:8085503 FLJ10661 -0.51 -6.31 -0.36 1.19e-9 Retinal vascular caliber; CESC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg18876405 chr7:65276391 NA 0.45 6.09 0.35 3.92e-9 Aortic root size; CESC cis rs4803455 0.565 rs11083616 chr19:41865643 A/G cg08477640 chr19:41863820 B9D2 -0.48 -6.78 -0.38 7.67e-11 Migraine;Coronary artery disease; CESC cis rs7551222 0.752 rs4951407 chr1:204558070 G/T cg20240347 chr1:204465584 NA 0.31 6.47 0.37 4.68e-10 Schizophrenia; CESC trans rs7937682 0.889 rs479667 chr11:111484034 C/T cg18187862 chr3:45730750 SACM1L 0.47 6.02 0.35 5.75e-9 Primary sclerosing cholangitis; CESC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg24549020 chr5:56110836 MAP3K1 -0.54 -6.11 -0.35 3.54e-9 Initial pursuit acceleration; CESC cis rs8062405 0.755 rs2077031 chr16:28603168 T/A cg07382826 chr16:28625726 SULT1A1 0.4 6.6 0.38 2.18e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2274273 0.837 rs11625968 chr14:55801004 G/C cg04306507 chr14:55594613 LGALS3 0.3 5.75 0.33 2.48e-8 Protein biomarker; CESC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg05332525 chr7:65337924 VKORC1L1 0.52 6.43 0.37 6.04e-10 Aortic root size; CESC cis rs4803468 1.000 rs3810175 chr19:41904396 C/T cg14132834 chr19:41945861 ATP5SL 0.67 8.38 0.46 3.22e-15 Height; CESC cis rs7247513 0.658 rs4804728 chr19:12752928 G/A cg01871581 chr19:12707946 ZNF490 -0.74 -10.68 -0.55 2.17e-22 Bipolar disorder; CESC cis rs12711979 0.729 rs6714956 chr2:3820454 T/C cg17052675 chr2:3827356 NA -0.42 -6.47 -0.37 4.59e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg06784218 chr1:46089804 CCDC17 -0.3 -5.16 -0.3 4.9e-7 High light scatter reticulocyte count; CESC cis rs155076 1.000 rs658244 chr13:21850976 T/C cg11317459 chr13:21872234 NA -1.03 -11.01 -0.56 1.8e-23 White matter hyperintensity burden; CESC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg04772025 chr11:68637568 NA -0.49 -5.74 -0.33 2.59e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3857067 1.000 rs28840089 chr4:95000403 A/T cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.0 -0.44 3.93e-14 QT interval; CESC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.55 0.64 3.99e-32 Prudent dietary pattern; CESC cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg24308560 chr3:49941425 MST1R 0.6 8.72 0.47 3.17e-16 Body mass index; CESC cis rs8062405 0.573 rs7187575 chr16:28990101 C/T cg05966235 chr16:28915196 ATP2A1 -0.4 -5.61 -0.33 5.1e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs116161686 0.500 rs55871867 chr1:210051029 A/G cg22029157 chr1:209979665 IRF6 0.68 7.09 0.4 1.19e-11 Coronary artery disease; CESC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg21963583 chr11:68658836 MRPL21 0.42 5.89 0.34 1.15e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.583 rs4244602 chr17:17841456 A/G cg16928487 chr17:17741425 SREBF1 -0.59 -10.04 -0.53 2.52e-20 Total body bone mineral density; CESC trans rs11098499 0.954 rs10017371 chr4:120293776 A/G cg25214090 chr10:38739885 LOC399744 0.69 9.32 0.5 4.71e-18 Corneal astigmatism; CESC cis rs9815354 0.812 rs73081370 chr3:41916258 G/C cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.93e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs561341 1.000 rs55959993 chr17:30254771 C/G cg00745463 chr17:30367425 LRRC37B -0.85 -7.62 -0.42 4.38e-13 Hip circumference adjusted for BMI; CESC cis rs7772486 0.686 rs1292334 chr6:145968288 A/G cg05347473 chr6:146136440 FBXO30 0.55 7.06 0.4 1.5e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9488822 0.676 rs12202181 chr6:116327102 A/G cg15226275 chr6:116381976 FRK 0.25 6.18 0.35 2.39e-9 Cholesterol, total;LDL cholesterol; CESC cis rs11098499 0.863 rs12502389 chr4:120454191 A/G cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs8014204 0.870 rs3742790 chr14:75308758 C/T cg11812906 chr14:75593930 NEK9 -0.43 -5.46 -0.32 1.07e-7 Caffeine consumption; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22100228 chr8:94929017 PDP1 0.63 6.95 0.39 2.89e-11 Gut microbiome composition (summer); CESC trans rs17685 0.625 rs1639630 chr7:75730499 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.5 0.61 1.68e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -6.44 -0.37 5.55e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg27005181 chr13:20208413 MPHOSPH8 -0.43 -6.19 -0.36 2.24e-9 Vertical cup-disc ratio; CESC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Depression; CESC cis rs8031584 1.000 rs35811129 chr15:31241346 G/A cg08109568 chr15:31115862 NA -0.75 -9.45 -0.5 1.91e-18 Huntington's disease progression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17597374 chr11:61106595 DAK -0.68 -7.88 -0.44 8.29e-14 Gut microbiome composition (summer); CESC cis rs9403521 1.000 rs9403521 chr6:143994199 C/T cg21026257 chr6:143998961 PHACTR2 -0.47 -5.16 -0.3 4.84e-7 Obesity-related traits; CESC cis rs1538970 0.924 rs11211118 chr1:45930270 A/C cg24296786 chr1:45957014 TESK2 -0.46 -5.17 -0.3 4.58e-7 Platelet count; CESC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg22143856 chr6:28129313 ZNF389 0.42 5.24 0.31 3.35e-7 Parkinson's disease; CESC cis rs17376456 0.741 rs12374432 chr5:93481348 C/A cg25358565 chr5:93447407 FAM172A 1.17 11.51 0.58 3.92e-25 Diabetic retinopathy; CESC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg01411255 chr17:61851458 DDX42;CCDC47 1.06 17.85 0.74 2.52e-47 Height; CESC cis rs1801251 1.000 rs10933412 chr2:233707226 G/C cg25237894 chr2:233734115 C2orf82 -0.46 -8.1 -0.45 2.01e-14 Coronary artery disease; CESC cis rs2742417 0.603 rs1019129 chr3:45780780 T/C cg04837898 chr3:45731254 SACM1L -0.49 -6.31 -0.36 1.19e-9 Response to anti-depressant treatment in major depressive disorder; CESC trans rs61931739 0.534 rs11052959 chr12:33997095 T/C cg26384229 chr12:38710491 ALG10B 0.58 8.13 0.45 1.64e-14 Morning vs. evening chronotype; CESC cis rs523522 0.962 rs2235218 chr12:120888619 A/C cg12219531 chr12:120966889 COQ5 0.73 9.13 0.49 1.83e-17 High light scatter reticulocyte count; CESC cis rs300703 0.654 rs393277 chr2:121539 G/T cg21211680 chr2:198530 NA -0.97 -9.92 -0.52 6.44e-20 Blood protein levels; CESC cis rs67311347 1.000 rs6793596 chr3:40457795 C/T cg24209194 chr3:40518798 ZNF619 0.5 6.16 0.35 2.66e-9 Renal cell carcinoma; CESC cis rs6674176 0.597 rs6671164 chr1:44403489 G/T cg23954153 chr1:44402353 ARTN -0.34 -5.24 -0.31 3.22e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09352908 chr3:37017749 NA -0.7 -8.3 -0.45 5.37e-15 Gut microbiome composition (summer); CESC trans rs1814175 0.645 rs10839382 chr11:49823172 C/T cg03929089 chr4:120376271 NA -0.89 -13.85 -0.65 3.4e-33 Height; CESC cis rs7917772 0.503 rs10883732 chr10:104293461 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.81 -0.34 1.82e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs4423214 0.879 rs1790353 chr11:71136730 C/T cg05163923 chr11:71159392 DHCR7 -0.63 -7.28 -0.41 3.75e-12 Vitamin D levels; CESC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg18032046 chr6:28092343 ZSCAN16 -0.53 -5.98 -0.35 7.05e-9 Parkinson's disease; CESC cis rs73411413 0.661 rs11599981 chr11:1520063 C/T cg03836507 chr11:1520812 HCCA2 -0.48 -5.27 -0.31 2.87e-7 Myringotomy; CESC cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9649465 0.967 rs768680 chr7:123364127 T/C cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.33e-7 Migraine; CESC cis rs7202877 0.706 rs247447 chr16:75486648 A/G cg04384234 chr16:75411784 CFDP1 0.48 5.6 0.33 5.22e-8 Type 2 diabetes;Type 1 diabetes; CESC trans rs6600671 0.934 rs11249431 chr1:121286203 A/G cg17023122 chr1:144479586 NA -0.5 -6.61 -0.38 2.11e-10 Hip geometry; CESC cis rs2109514 0.593 rs9649394 chr7:116171510 A/G cg04696780 chr7:116139425 CAV2 -0.3 -5.45 -0.32 1.12e-7 Prevalent atrial fibrillation; CESC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.55 6.66 0.38 1.55e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.41 -0.37 6.76e-10 Life satisfaction; CESC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg22508957 chr16:3507546 NAT15 0.57 9.03 0.48 3.76e-17 Tuberculosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07464025 chr10:13482639 BEND7 0.6 6.63 0.38 1.9e-10 Gut microbiome composition (summer); CESC trans rs1549733 0.552 rs16857862 chr2:218420477 T/C cg23408253 chr19:17438755 ANO8 -0.46 -6.01 -0.35 6.2e-9 Optic disc area; CESC cis rs7301826 1.000 rs4759787 chr12:131290180 A/C cg11011512 chr12:131303247 STX2 0.4 5.08 0.3 7.16e-7 Plasma plasminogen activator levels; CESC cis rs7336332 0.598 rs9581850 chr13:28012265 A/G cg22138327 chr13:27999177 GTF3A 0.62 5.82 0.34 1.71e-8 Weight; CESC cis rs1816752 0.935 rs4770676 chr13:25003883 A/G cg02811702 chr13:24901961 NA 0.38 5.49 0.32 9.38e-8 Obesity-related traits; CESC cis rs752010 0.905 rs10890150 chr1:42095603 A/C cg06885757 chr1:42089581 HIVEP3 0.54 8.91 0.48 8.52e-17 Lupus nephritis in systemic lupus erythematosus; CESC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg19901468 chr14:105411992 AHNAK2 -0.59 -8.46 -0.46 1.81e-15 Rheumatoid arthritis; CESC cis rs34638657 0.732 rs12597534 chr16:82200276 G/T cg09439754 chr16:82129088 HSD17B2 -0.35 -6.22 -0.36 1.93e-9 Lung adenocarcinoma; CESC cis rs7680126 0.633 rs4698023 chr4:10304726 A/G cg00071950 chr4:10020882 SLC2A9 -0.43 -5.03 -0.3 8.86e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs208520 1.000 rs72882079 chr6:66973878 T/C cg07460842 chr6:66804631 NA 0.9 10.27 0.53 4.61e-21 Exhaled nitric oxide output; CESC trans rs9929218 0.954 rs12924033 chr16:68822599 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -7.97 -0.44 4.84e-14 Colorectal cancer; CESC cis rs7937682 0.961 rs17113227 chr11:111620491 A/G cg22437258 chr11:111473054 SIK2 0.55 6.52 0.37 3.44e-10 Primary sclerosing cholangitis; CESC cis rs2742234 0.656 rs1864400 chr10:43610366 G/A cg15436174 chr10:43711423 RASGEF1A -0.45 -5.18 -0.3 4.4e-7 Hirschsprung disease; CESC cis rs727505 0.721 rs55890146 chr7:124755461 A/T cg23710748 chr7:124431027 NA -0.38 -6.17 -0.35 2.6e-9 Lewy body disease; CESC cis rs4332037 0.851 rs34040190 chr7:1920356 G/A cg23422044 chr7:1970798 MAD1L1 -0.59 -6.1 -0.35 3.68e-9 Bipolar disorder; CESC cis rs4901847 0.643 rs1998101 chr14:58598706 T/C cg15908186 chr14:58618357 C14orf37 0.35 5.15 0.3 4.98e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg16405210 chr4:1374714 KIAA1530 -0.49 -6.19 -0.36 2.34e-9 Obesity-related traits; CESC cis rs6456156 0.565 rs12529959 chr6:167469292 T/C cg23791538 chr6:167370224 RNASET2 -0.5 -6.47 -0.37 4.66e-10 Primary biliary cholangitis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23181591 chr8:123793873 ZHX2 -0.46 -6.12 -0.35 3.44e-9 Height; CESC trans rs9324380 0.735 rs4634961 chr1:98487763 A/G cg27522060 chr15:65360366 RASL12 -0.6 -6.11 -0.35 3.55e-9 Intelligence (multi-trait analysis); CESC cis rs6815814 0.950 rs5743593 chr4:38802913 A/G cg02016764 chr4:38805732 TLR1 -0.63 -7.4 -0.41 1.8e-12 Breast cancer; CESC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg27535305 chr1:53392650 SCP2 0.31 5.48 0.32 9.77e-8 Monocyte count; CESC cis rs754466 1.000 rs12220328 chr10:79681482 G/C cg17075019 chr10:79541650 NA -0.7 -8.93 -0.48 7.17e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.10.2372731R chr10:112966440 NA -0.47 -6.3 -0.36 1.25e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg24060327 chr5:131705240 SLC22A5 -0.47 -6.09 -0.35 4.03e-9 Acylcarnitine levels; CESC cis rs7809950 0.678 rs62482507 chr7:107024488 T/G cg23024343 chr7:107201750 COG5 -0.6 -7.6 -0.42 5.09e-13 Coronary artery disease; CESC cis rs1003719 0.707 rs9976360 chr21:38587860 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.12 -0.45 1.81e-14 Eye color traits; CESC cis rs2070488 0.965 rs6805386 chr3:38557921 T/C cg24069376 chr3:38537580 EXOG -0.46 -8.5 -0.46 1.37e-15 Electrocardiographic conduction measures; CESC cis rs55794721 0.509 rs2375313 chr1:25748235 G/A cg03538708 chr1:25844672 NA -0.42 -6.26 -0.36 1.58e-9 Plateletcrit;Mean corpuscular volume; CESC cis rs7086627 0.515 rs10887905 chr10:82210855 A/T cg03267442 chr10:82210566 NA -0.34 -5.66 -0.33 3.98e-8 Post bronchodilator FEV1; CESC cis rs11098499 0.863 rs10019674 chr4:120443489 C/T cg24375607 chr4:120327624 NA -0.49 -6.15 -0.35 2.77e-9 Corneal astigmatism; CESC cis rs3011225 0.710 rs3011222 chr1:44317545 C/T cg12908607 chr1:44402522 ARTN -0.46 -6.6 -0.38 2.26e-10 Amyotrophic lateral sclerosis (age of onset); CESC cis rs62064224 0.702 rs735555 chr17:30817450 A/G cg25809561 chr17:30822961 MYO1D -0.44 -6.23 -0.36 1.79e-9 Schizophrenia; CESC cis rs1348850 0.609 rs1348851 chr2:178418677 C/T cg23306229 chr2:178417860 TTC30B -0.86 -7.47 -0.42 1.14e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.71 -0.51 2.98e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02184338 chr7:101331866 NA -0.45 -6.14 -0.35 2.99e-9 Fibrinogen levels; CESC cis rs1153858 1.000 rs1890565 chr15:45663299 T/C cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs11098499 0.954 rs7681544 chr4:120411255 T/C cg24375607 chr4:120327624 NA 0.46 5.63 0.33 4.52e-8 Corneal astigmatism; CESC cis rs131805 1.000 rs131805 chr22:50964153 T/C cg25309564 chr22:51001381 C22orf41 0.64 6.39 0.37 7.6e-10 Granulocyte percentage of myeloid white cells; CESC cis rs4523957 0.583 rs8077597 chr17:2043818 C/T cg16513277 chr17:2031491 SMG6 -0.79 -11.73 -0.58 6.95e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg02269571 chr22:50332266 NA -0.55 -6.33 -0.36 1.05e-9 Schizophrenia; CESC cis rs2816062 0.813 rs2745318 chr1:18895844 C/T cg18795169 chr1:18902165 NA 0.92 18.72 0.75 2.15e-50 Urate levels in lean individuals; CESC cis rs7216064 1.000 rs11079707 chr17:65835617 A/G cg07042672 chr17:66097459 LOC651250 0.51 5.72 0.33 2.86e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4654899 0.627 rs637990 chr1:21047616 A/G cg05370193 chr1:21551575 ECE1 -0.37 -5.33 -0.31 2.15e-7 Superior frontal gyrus grey matter volume; CESC cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg10523679 chr1:76189770 ACADM 0.75 10.09 0.53 1.8e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs13191362 1.000 rs35583420 chr6:163214327 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.57 5.35 0.31 1.91e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs35306767 0.855 rs12781100 chr10:838636 C/T cg26597838 chr10:835615 NA 1.18 12.02 0.59 7.45e-27 Eosinophil percentage of granulocytes; CESC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg04315214 chr1:2043799 PRKCZ -0.45 -7.35 -0.41 2.54e-12 Height; CESC cis rs2997447 0.706 rs17184877 chr1:26443908 A/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.41 0.32 1.41e-7 QRS complex (12-leadsum); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg27319730 chr6:36237037 PNPLA1 -0.44 -6.47 -0.37 4.69e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs5769765 0.862 rs9616774 chr22:50290599 G/A cg26441486 chr22:50317300 CRELD2 0.38 5.32 0.31 2.17e-7 Schizophrenia; CESC cis rs1580019 0.885 rs4460270 chr7:32496450 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.72 9.97 0.52 4.3e-20 Cognitive ability; CESC cis rs2228479 0.867 rs11646448 chr16:89966357 A/T cg06558623 chr16:89946397 TCF25 1.03 9.47 0.5 1.58e-18 Skin colour saturation; CESC cis rs4948102 0.731 rs4543497 chr7:56047215 T/C cg09872392 chr7:56161020 PHKG1 -0.46 -7.25 -0.41 4.59e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs2425143 1.000 rs56052651 chr20:34344084 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 5.59 0.32 5.53e-8 Blood protein levels; CESC cis rs6460942 0.915 rs75158182 chr7:12456059 C/T cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg27170947 chr2:26402098 FAM59B -0.6 -7.11 -0.4 1.1e-11 Gut microbiome composition (summer); CESC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg06456125 chr7:65229604 NA -0.43 -5.65 -0.33 4.24e-8 Aortic root size; CESC cis rs7580658 0.864 rs4150441 chr2:128040915 T/C cg10021288 chr2:128175891 PROC -0.38 -6.03 -0.35 5.43e-9 Protein C levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05559558 chr6:138483092 KIAA1244 0.6 7.07 0.4 1.38e-11 Gut microbiome composition (summer); CESC cis rs3820068 0.581 rs59991988 chr1:15950552 T/A cg17385448 chr1:15911702 AGMAT 0.42 6.88 0.39 4.26e-11 Systolic blood pressure; CESC cis rs79839061 0.610 rs11726280 chr4:864077 C/T cg07828340 chr4:882639 GAK 1.08 7.9 0.44 7.59e-14 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11737246 chr15:40401244 BMF -0.45 -6.2 -0.36 2.14e-9 Fibrinogen levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26815021 chr17:74733172 MIR636;MFSD11;SFRS2 -0.47 -6.88 -0.39 4.19e-11 Gambling; CESC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg20295408 chr7:1910781 MAD1L1 -0.4 -5.22 -0.31 3.55e-7 Bipolar disorder and schizophrenia; CESC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg08888203 chr3:10149979 C3orf24 0.49 6.17 0.35 2.49e-9 Alzheimer's disease; CESC cis rs854765 0.547 rs7212167 chr17:17913504 G/A cg04398451 chr17:18023971 MYO15A -0.7 -10.3 -0.53 3.77e-21 Total body bone mineral density; CESC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg23982607 chr1:1823379 GNB1 -0.8 -12.99 -0.62 3.33e-30 Body mass index; CESC cis rs561341 1.000 rs521919 chr17:30298039 G/T cg12193833 chr17:30244370 NA -0.59 -5.89 -0.34 1.19e-8 Hip circumference adjusted for BMI; CESC cis rs9291683 0.588 rs2240721 chr4:10020564 G/A cg02734326 chr4:10020555 SLC2A9 0.52 7.49 0.42 9.99e-13 Bone mineral density; CESC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg04267008 chr7:1944627 MAD1L1 -0.61 -7.41 -0.41 1.65e-12 Bipolar disorder and schizophrenia; CESC cis rs11711311 1.000 rs9830975 chr3:113486019 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.73 10.31 0.54 3.51e-21 IgG glycosylation; CESC cis rs9650657 0.645 rs4841407 chr8:10516185 G/A cg27411982 chr8:10470053 RP1L1 -0.39 -5.16 -0.3 4.9e-7 Neuroticism; CESC cis rs7737355 0.773 rs32112 chr5:131048122 G/A cg06307176 chr5:131281290 NA 0.36 5.04 0.3 8.7e-7 Life satisfaction; CESC cis rs8180040 0.620 rs1811652 chr3:47208698 C/G cg27129171 chr3:47204927 SETD2 -0.67 -9.83 -0.52 1.2e-19 Colorectal cancer; CESC cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.05 10.33 0.54 2.97e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs763014 0.865 rs4006748 chr16:632225 T/C cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08493338 chr16:354269 AXIN1 0.55 7.51 0.42 8.85e-13 Fibrinogen levels; CESC trans rs208520 0.690 rs851465 chr6:66840293 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -13.08 -0.63 1.69e-30 Exhaled nitric oxide output; CESC cis rs2243480 1.000 rs2961102 chr7:65424658 A/G cg25894440 chr7:65020034 NA -0.68 -5.88 -0.34 1.22e-8 Diabetic kidney disease; CESC cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7582720 0.945 rs72936860 chr2:203783484 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs17384381 1.000 rs12743049 chr1:85897386 G/A cg16011679 chr1:85725395 C1orf52 0.74 7.58 0.42 5.98e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg03467027 chr4:99064603 C4orf37 0.48 5.9 0.34 1.11e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7264396 0.635 rs6058355 chr20:34491343 A/G cg17201900 chr20:34330562 RBM39 0.49 5.1 0.3 6.63e-7 Total cholesterol levels; CESC cis rs7523050 0.643 rs35520362 chr1:109419841 C/T cg08274380 chr1:109419600 GPSM2 0.92 6.41 0.37 6.62e-10 Fat distribution (HIV); CESC cis rs17253792 0.822 rs79807559 chr14:56108117 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.65 0.33 4.2e-8 Putamen volume; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11857025 chr1:109633344 TMEM167B 0.46 6.39 0.37 7.34e-10 Asthma; CESC cis rs10899021 0.920 rs11236174 chr11:74334201 G/A cg25880958 chr11:74394337 NA -0.74 -7.86 -0.43 9.71e-14 Response to metformin (IC50); CESC cis rs637571 0.522 rs679581 chr11:65746653 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.46 0.37 4.88e-10 Eosinophil percentage of white cells; CESC cis rs7216064 1.000 rs2128792 chr17:65857177 C/T cg07042672 chr17:66097459 LOC651250 -0.54 -5.56 -0.32 6.49e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1506636 1.000 rs614645 chr7:123442349 T/C cg03229431 chr7:123269106 ASB15 0.48 5.99 0.35 6.71e-9 Plateletcrit;Platelet count; CESC cis rs10751667 0.643 rs10902234 chr11:935578 A/G cg20946044 chr11:1010712 AP2A2 -0.38 -5.23 -0.31 3.48e-7 Alzheimer's disease (late onset); CESC cis rs2243480 0.711 rs2420172 chr7:65635341 T/C cg12463550 chr7:65579703 CRCP -0.73 -5.71 -0.33 3.1e-8 Diabetic kidney disease; CESC cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg24733560 chr20:60626293 TAF4 0.48 7.18 0.4 6.91e-12 Body mass index; CESC cis rs709400 1.000 rs10135248 chr14:104122310 T/C cg24130564 chr14:104152367 KLC1 -0.44 -5.74 -0.33 2.57e-8 Body mass index; CESC cis rs80130819 0.515 rs6580656 chr12:48570604 C/T cg05342945 chr12:48394962 COL2A1 -0.48 -5.68 -0.33 3.53e-8 Prostate cancer; CESC trans rs7246760 1.000 rs57736549 chr19:9937558 A/G cg02900749 chr2:68251473 NA -0.82 -6.85 -0.39 5.23e-11 Pursuit maintenance gain; CESC cis rs7116495 0.609 rs7942626 chr11:71703849 G/A cg07596299 chr11:71824057 C11orf51 -0.8 -5.35 -0.31 1.92e-7 Severe influenza A (H1N1) infection; CESC trans rs561341 0.714 rs7218466 chr17:30263314 A/G cg20587970 chr11:113659929 NA -0.8 -9.94 -0.52 5.27e-20 Hip circumference adjusted for BMI; CESC cis rs9863 0.861 rs34878139 chr12:124446253 T/C cg17562584 chr12:124393655 DNAH10 0.32 5.48 0.32 9.77e-8 White blood cell count; CESC cis rs11750568 0.967 rs931618 chr5:178514747 T/C cg10208897 chr5:178548229 ADAMTS2 0.39 5.43 0.32 1.29e-7 Height; CESC cis rs950027 0.595 rs2486288 chr15:45712339 T/C cg21132104 chr15:45694354 SPATA5L1 0.65 8.47 0.46 1.66e-15 Response to fenofibrate (adiponectin levels); CESC cis rs295140 0.546 rs295137 chr2:201150040 C/T cg23649088 chr2:200775458 C2orf69 0.46 6.0 0.35 6.31e-9 QT interval; CESC cis rs11792861 0.890 rs2900481 chr9:111831825 G/A cg13535736 chr9:111863775 C9orf5 -0.51 -6.84 -0.39 5.58e-11 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13404532 chr3:128483276 RAB7A -0.59 -6.76 -0.38 8.59e-11 Gut microbiome composition (summer); CESC cis rs7336332 0.598 rs7669 chr13:28009851 C/T cg22138327 chr13:27999177 GTF3A 0.61 5.9 0.34 1.12e-8 Weight; CESC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.72 0.64 1.03e-32 Prudent dietary pattern; CESC cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg05340658 chr4:99064831 C4orf37 0.75 10.73 0.55 1.56e-22 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04515913 chr15:89182103 ISG20 -0.46 -6.53 -0.37 3.25e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7448080 0.510 rs1501762 chr5:123242975 G/A cg10971134 chr1:56877429 NA 0.94 6.3 0.36 1.21e-9 Alcohol dependence (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18864739 chr5:31214888 CDH6 -0.42 -6.49 -0.37 4.09e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2011503 1.000 rs11669730 chr19:19648713 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg10523679 chr1:76189770 ACADM 0.73 8.56 0.47 9.29e-16 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11098499 0.954 rs9993199 chr4:120392873 A/G cg25214090 chr10:38739885 LOC399744 -0.7 -10.11 -0.53 1.56e-20 Corneal astigmatism; CESC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2070997 0.618 rs3780282 chr9:133743654 G/A cg01000188 chr9:133769184 QRFP 0.34 5.29 0.31 2.61e-7 Response to amphetamines; CESC cis rs244293 0.831 rs11654268 chr17:53151290 A/G cg19360675 chr17:53046073 COX11;STXBP4 0.42 5.38 0.31 1.66e-7 Menarche (age at onset); CESC cis rs7647973 1.000 rs11928090 chr3:49604904 G/A cg06212747 chr3:49208901 KLHDC8B 0.6 7.83 0.43 1.18e-13 Menarche (age at onset); CESC cis rs72781680 0.611 rs72797824 chr2:24356456 T/G cg06627628 chr2:24431161 ITSN2 -0.69 -6.8 -0.39 6.87e-11 Lymphocyte counts; CESC cis rs28830936 1.000 rs12441300 chr15:42102845 A/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.44 -5.92 -0.34 9.69e-9 Diastolic blood pressure; CESC cis rs754466 0.724 rs11002318 chr10:79633807 G/A cg17075019 chr10:79541650 NA -0.86 -12.94 -0.62 5.28e-30 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08306365 chr15:62543301 NA -0.51 -6.72 -0.38 1.11e-10 Gut microbiome composition (summer); CESC cis rs4594175 0.926 rs7160948 chr14:51612537 T/A cg23942311 chr14:51606299 NA 0.36 5.43 0.32 1.29e-7 Cancer; CESC cis rs1003719 0.788 rs3787783 chr21:38462959 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26728986 chr19:45540955 SFRS16;RELB -0.6 -6.69 -0.38 1.29e-10 Gut microbiome composition (summer); CESC cis rs9581857 0.579 rs79904593 chr13:27996893 G/A cg01674679 chr13:27998804 GTF3A -0.69 -5.45 -0.32 1.13e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs2273669 0.667 rs12215344 chr6:109329641 A/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.06 -0.35 4.74e-9 Prostate cancer; CESC cis rs2806561 0.894 rs598438 chr1:23531563 C/T cg12483005 chr1:23474871 LUZP1 0.33 5.17 0.3 4.56e-7 Height; CESC cis rs524281 0.861 rs10896080 chr11:65876796 G/A cg14036092 chr11:66035641 RAB1B -0.63 -6.45 -0.37 5.41e-10 Electroencephalogram traits; CESC cis rs9308731 0.605 rs6754738 chr2:111948543 T/C cg04202892 chr2:111875749 ACOXL 0.4 5.41 0.32 1.42e-7 Chronic lymphocytic leukemia; CESC cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg03433033 chr1:76189801 ACADM 0.57 5.57 0.32 6.26e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11638352 1.000 rs2615292 chr15:44414376 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs73206853 0.563 rs1973505 chr12:111160003 A/G cg12870014 chr12:110450643 ANKRD13A -0.79 -7.94 -0.44 5.58e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7267979 0.780 rs2500413 chr20:25241155 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.71 11.37 0.57 1.18e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs4268898 0.735 rs12469585 chr2:24489054 A/T cg06627628 chr2:24431161 ITSN2 0.58 7.41 0.41 1.65e-12 Asthma; CESC cis rs10743315 0.557 rs17343287 chr12:19420064 T/C cg02471346 chr12:19282374 PLEKHA5 0.71 5.19 0.3 4.15e-7 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.89 0.48 9.9e-17 Colonoscopy-negative controls vs population controls; CESC cis rs9325144 0.647 rs11169222 chr12:39105210 C/T cg26384229 chr12:38710491 ALG10B -0.5 -7.06 -0.4 1.47e-11 Morning vs. evening chronotype; CESC cis rs10752881 0.967 rs4652757 chr1:182974750 T/A ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Colorectal cancer; CESC cis rs868036 1.000 rs4776975 chr15:68102220 G/C cg08079166 chr15:68083412 MAP2K5 0.44 6.95 0.39 2.89e-11 Restless legs syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08874598 chr8:102217901 ZNF706 0.57 6.37 0.36 8.38e-10 Gut microbiome composition (summer); CESC cis rs7786877 0.508 rs11765509 chr7:100310990 T/G cg16850897 chr7:100343110 ZAN -0.66 -8.14 -0.45 1.54e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg24829409 chr8:58192753 C8orf71 -0.67 -7.97 -0.44 4.6e-14 Developmental language disorder (linguistic errors); CESC cis rs2795502 0.938 rs3121324 chr10:43379515 C/T cg20628663 chr10:43360327 NA 0.56 6.64 0.38 1.78e-10 Blood protein levels; CESC cis rs2066819 1.000 rs11171806 chr12:56733531 A/G cg26734620 chr12:56694298 CS -0.97 -6.13 -0.35 3.18e-9 Psoriasis vulgaris; CESC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg08499158 chr17:42289980 UBTF -0.52 -6.54 -0.37 3.23e-10 Total body bone mineral density; CESC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg27266027 chr21:40555129 PSMG1 0.47 5.5 0.32 8.74e-8 Cognitive function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00759295 chr19:42388476 ARHGEF1 -0.49 -6.57 -0.37 2.7e-10 Fibrinogen levels; CESC cis rs1483890 0.642 rs1843050 chr3:69403918 C/T cg22125112 chr3:69402811 FRMD4B -0.38 -5.19 -0.3 4.26e-7 Resting heart rate; CESC cis rs2228479 0.702 rs11646374 chr16:89857935 G/A cg19635926 chr16:89946313 TCF25 0.68 5.16 0.3 4.81e-7 Skin colour saturation; CESC cis rs13108904 0.604 rs11946375 chr4:1313488 T/C cg13395646 chr4:1353034 KIAA1530 -0.41 -5.12 -0.3 5.76e-7 Obesity-related traits; CESC cis rs2658782 0.951 rs72972357 chr11:93118840 T/C cg15737290 chr11:93063684 CCDC67 -0.51 -6.21 -0.36 2.07e-9 Pulmonary function decline; CESC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.56 0.32 6.43e-8 Menopause (age at onset); CESC cis rs1569175 0.850 rs3106088 chr2:200907393 A/C cg19045956 chr2:200819837 C2orf60;C2orf47 0.64 5.41 0.32 1.44e-7 Response to treatment for acute lymphoblastic leukemia; CESC cis rs936229 0.690 rs2472300 chr15:75033909 A/G cg14664628 chr15:75095509 CSK -0.75 -10.21 -0.53 7.44e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15554505 chr19:22123728 NA -0.57 -7.78 -0.43 1.67e-13 Gut microbiome composition (summer); CESC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg06108461 chr20:60628389 TAF4 -0.58 -7.7 -0.43 2.67e-13 Body mass index; CESC cis rs916888 0.610 rs142167 chr17:44795234 C/T cg15921436 chr17:44337874 NA -0.47 -5.99 -0.35 6.67e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9581857 0.615 rs79553479 chr13:28007862 G/A cg01674679 chr13:27998804 GTF3A -0.71 -5.67 -0.33 3.75e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7188861 0.768 rs62023605 chr16:11380861 A/C cg01510278 chr16:11456238 NA 0.33 5.12 0.3 5.81e-7 HDL cholesterol; CESC cis rs7851660 0.809 rs3824495 chr9:100663700 A/C cg13688889 chr9:100608707 NA 0.62 8.98 0.48 5.2e-17 Strep throat; CESC cis rs7914558 0.966 rs4532960 chr10:104667406 C/T cg15744005 chr10:104629667 AS3MT -0.35 -5.5 -0.32 8.98e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17806437 chr15:42211581 EHD4 0.53 7.39 0.41 1.98e-12 Fibrinogen levels; CESC cis rs12410462 0.581 rs111356515 chr1:227537236 C/G cg04117972 chr1:227635322 NA 0.64 5.35 0.31 1.9e-7 Major depressive disorder; CESC cis rs12325245 0.536 rs34161389 chr16:58622604 G/A cg05725404 chr16:58534157 NDRG4 -0.63 -5.34 -0.31 2.01e-7 Schizophrenia; CESC cis rs78456975 0.506 rs6756310 chr2:1549809 A/G cg26248373 chr2:1572462 NA -0.58 -6.59 -0.38 2.38e-10 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs3806843 0.735 rs778597 chr5:140040665 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.43 -0.32 1.28e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2228479 0.850 rs62056063 chr16:89903680 C/T cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg18230493 chr5:56204884 C5orf35 -0.75 -9.01 -0.48 4.28e-17 Initial pursuit acceleration; CESC cis rs3126085 0.935 rs12407553 chr1:152297517 A/G cg03465714 chr1:152285911 FLG 0.5 5.71 0.33 2.96e-8 Atopic dermatitis; CESC cis rs4662945 0.603 rs10168574 chr2:130267823 C/T cg05962382 chr2:130345044 NA -0.48 -6.8 -0.39 7.04e-11 Response to cytidine analogues (gemcitabine); CESC cis rs561341 1.000 rs506766 chr17:30289659 T/C cg00745463 chr17:30367425 LRRC37B -0.81 -6.94 -0.39 3.02e-11 Hip circumference adjusted for BMI; CESC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg16145915 chr7:1198662 ZFAND2A -0.64 -9.7 -0.51 3.1400000000000002e-19 Longevity;Endometriosis; CESC cis rs1003719 0.713 rs7277150 chr21:38490006 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.7 0.47 3.66e-16 Eye color traits; CESC cis rs734999 0.545 rs12749591 chr1:2563250 G/T cg20673091 chr1:2541236 MMEL1 -0.47 -8.15 -0.45 1.49e-14 Ulcerative colitis; CESC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs2251381 0.750 rs2251186 chr21:30528880 G/A cg08807101 chr21:30365312 RNF160 0.68 8.22 0.45 9.12e-15 Selective IgA deficiency; CESC cis rs818427 0.548 rs395858 chr5:112187356 G/A cg07820702 chr5:112228657 REEP5 0.39 5.18 0.3 4.41e-7 Total body bone mineral density; CESC cis rs7020830 0.894 rs12337316 chr9:37148105 G/A cg14294708 chr9:37120828 ZCCHC7 1.15 22.08 0.8 5.18e-62 Schizophrenia; CESC cis rs250677 0.522 rs12520924 chr5:148349149 C/T cg18129178 chr5:148520854 ABLIM3 0.47 5.04 0.3 8.44e-7 Breast cancer; CESC cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1670533 1.000 rs62879260 chr4:1050850 T/C cg04106633 chr4:1044584 NA 0.41 5.12 0.3 5.87e-7 Recombination rate (females); CESC cis rs2836950 0.772 rs62222988 chr21:40569508 T/C cg11890956 chr21:40555474 PSMG1 -0.61 -7.59 -0.42 5.47e-13 Menarche (age at onset); CESC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg19717773 chr7:2847554 GNA12 -0.47 -6.75 -0.38 9.38e-11 Height; CESC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg18876405 chr7:65276391 NA 0.48 6.31 0.36 1.16e-9 Aortic root size; CESC trans rs7726839 0.561 rs72703046 chr5:580129 T/C cg25482853 chr8:67687455 SGK3 0.88 9.29 0.5 5.67e-18 Obesity-related traits; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg09360458 chr1:14075560 PRDM2 -0.5 -6.03 -0.35 5.48e-9 Psoriatic arthritis; CESC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg19163074 chr7:65112434 INTS4L2 0.43 5.32 0.31 2.22e-7 Aortic root size; CESC cis rs2228479 0.618 rs17233623 chr16:89811209 C/T cg14709524 chr16:89940631 TCF25 0.73 6.04 0.35 5.32e-9 Skin colour saturation; CESC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg05343316 chr1:45956843 TESK2 -0.48 -6.12 -0.35 3.41e-9 High light scatter reticulocyte count; CESC cis rs1008375 0.966 rs1860599 chr4:17638900 T/C cg15017067 chr4:17643749 FAM184B 0.36 5.19 0.3 4.25e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs6460942 0.659 rs6969309 chr7:12515847 T/C cg06484146 chr7:12443880 VWDE -0.71 -7.6 -0.42 5.22e-13 Coronary artery disease; CESC cis rs71403859 0.502 rs71403847 chr16:71468226 T/C cg08717414 chr16:71523259 ZNF19 -1.0 -9.12 -0.49 1.88e-17 Post bronchodilator FEV1; CESC cis rs752010 0.806 rs4641303 chr1:42091310 A/G cg06885757 chr1:42089581 HIVEP3 0.49 8.24 0.45 8.1e-15 Lupus nephritis in systemic lupus erythematosus; CESC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg19592336 chr6:28129416 ZNF389 0.61 8.24 0.45 8.13e-15 Depression; CESC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg27211696 chr2:191398769 TMEM194B 0.49 7.32 0.41 2.94e-12 Pulse pressure; CESC cis rs10788972 0.510 rs665817 chr1:54469948 T/G cg25741118 chr1:54482237 LDLRAD1 0.24 5.76 0.33 2.29e-8 Parkinson disease and lewy body pathology; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17976829 chr10:131934431 GLRX3 -0.47 -6.72 -0.38 1.13e-10 Gambling; CESC cis rs11229555 0.645 rs17474373 chr11:58191243 G/A cg15696309 chr11:58395628 NA -0.42 -5.05 -0.3 8.13e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg11764359 chr7:65958608 NA 0.81 11.74 0.58 6.73e-26 Aortic root size; CESC trans rs1728785 1.000 rs1728784 chr16:68591156 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.7 8.28 0.45 6.13e-15 Ulcerative colitis; CESC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg17724175 chr1:150552817 MCL1 0.33 5.13 0.3 5.51e-7 Melanoma; CESC cis rs77741769 0.529 rs1467283 chr12:121210220 G/C cg02419362 chr12:121203948 SPPL3 0.35 5.62 0.33 4.88e-8 Mean corpuscular volume; CESC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg06634786 chr22:41940651 POLR3H -0.68 -7.15 -0.4 8.28e-12 Vitiligo; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12366118 chr12:62860687 MON2 0.47 6.01 0.35 6.06e-9 Gut microbiota (bacterial taxa); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01172114 chr10:5979283 FBXO18 0.52 6.87 0.39 4.67e-11 Fibrinogen levels; CESC cis rs11792861 0.926 rs7856626 chr9:111775502 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.46 5.75 0.33 2.48e-8 Menarche (age at onset); CESC cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg12311346 chr5:56204834 C5orf35 0.64 8.49 0.46 1.47e-15 Initial pursuit acceleration; CESC cis rs9790314 0.663 rs1599379 chr3:160860665 A/G cg03342759 chr3:160939853 NMD3 -0.38 -5.16 -0.3 4.85e-7 Morning vs. evening chronotype; CESC cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg05347473 chr6:146136440 FBXO30 0.71 9.2 0.49 1.09e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs7845219 0.544 rs10956930 chr8:95919786 C/G cg16049864 chr8:95962084 TP53INP1 -0.49 -7.22 -0.41 5.48e-12 Type 2 diabetes; CESC cis rs62244186 0.593 rs9814298 chr3:44871899 T/A cg15225532 chr3:44803084 KIF15;KIAA1143 0.46 6.05 0.35 4.85e-9 Depressive symptoms; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15656181 chr5:71654404 PTCD2 -0.53 -6.57 -0.37 2.6200000000000003e-10 Gut microbiome composition (summer); CESC trans rs7582180 0.700 rs1437971 chr2:100986964 A/C cg26079571 chr12:3186499 TSPAN9 0.62 6.31 0.36 1.2e-9 Intelligence (multi-trait analysis); CESC cis rs12464559 0.649 rs11894672 chr2:152657055 C/T cg01189475 chr2:152685088 ARL5A 0.66 5.81 0.34 1.74e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs6987853 0.966 rs2084709 chr8:42423190 A/G cg09913449 chr8:42400586 C8orf40 0.4 6.49 0.37 4.15e-10 Mean corpuscular hemoglobin concentration; CESC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg24733560 chr20:60626293 TAF4 0.41 5.91 0.34 1.04e-8 Body mass index; CESC cis rs3096299 0.933 rs747485 chr16:89474094 T/C cg08822215 chr16:89438651 ANKRD11 -0.43 -6.64 -0.38 1.74e-10 Multiple myeloma (IgH translocation); CESC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg11905131 chr22:24372483 LOC391322 -0.74 -10.76 -0.55 1.23e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs35110281 0.627 rs1595167 chr21:44965874 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 7.61 0.42 4.68e-13 Mean corpuscular volume; CESC cis rs7116495 0.609 rs10736780 chr11:71650241 T/C cg26138937 chr11:71823887 C11orf51 -1.23 -8.41 -0.46 2.56e-15 Severe influenza A (H1N1) infection; CESC cis rs950169 0.922 rs2033284 chr15:84946273 C/T cg17507749 chr15:85114479 UBE2QP1 0.57 6.27 0.36 1.43e-9 Schizophrenia; CESC cis rs3820068 0.608 rs9660255 chr1:16031891 T/G cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.64e-7 Systolic blood pressure; CESC cis rs6500602 0.647 rs4786501 chr16:4536165 G/T cg08645402 chr16:4508243 NA -0.47 -7.22 -0.41 5.59e-12 Schizophrenia; CESC cis rs11098499 0.863 rs3775848 chr4:120447724 C/T cg09307838 chr4:120376055 NA 0.92 12.61 0.61 7.4e-29 Corneal astigmatism; CESC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.03e-9 Aortic root size; CESC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg15369054 chr17:80825471 TBCD -0.39 -5.59 -0.32 5.76e-8 Breast cancer; CESC cis rs6032067 0.929 rs13038355 chr20:43805555 C/T cg10761708 chr20:43804764 PI3 0.53 6.33 0.36 1.04e-9 Blood protein levels; CESC cis rs1707322 0.627 rs3014213 chr1:46045522 T/C cg05343316 chr1:45956843 TESK2 -0.53 -6.5 -0.37 3.87e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs477692 1.000 rs530466 chr10:131427717 A/G cg05714579 chr10:131428358 MGMT 0.56 7.7 0.43 2.72e-13 Response to temozolomide; CESC cis rs3857536 0.740 rs4710574 chr6:66890631 T/G cg07460842 chr6:66804631 NA -0.4 -5.23 -0.31 3.47e-7 Blood trace element (Cu levels); CESC trans rs9929218 1.000 rs4783681 chr16:68806508 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -8.03 -0.44 3.1e-14 Colorectal cancer; CESC cis rs10885582 0.781 rs7893570 chr10:116294295 G/A cg17056676 chr10:116301354 ABLIM1 -0.28 -5.13 -0.3 5.66e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg00033643 chr7:134001901 SLC35B4 0.41 5.24 0.31 3.25e-7 Mean platelet volume; CESC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg00684032 chr4:1343700 KIAA1530 0.56 8.59 0.47 7.56e-16 Obesity-related traits; CESC cis rs6964587 0.692 rs17672805 chr7:91573466 A/G cg17063962 chr7:91808500 NA -0.45 -6.25 -0.36 1.65e-9 Breast cancer; CESC cis rs9467711 0.606 rs9358937 chr6:26374274 C/G cg12826209 chr6:26865740 GUSBL1 0.62 5.11 0.3 6.24e-7 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05295236 chr10:135192197 PAOX 0.56 6.41 0.37 6.64e-10 Gut microbiome composition (summer); CESC cis rs752010 0.574 rs2148636 chr1:42119844 C/T cg06885757 chr1:42089581 HIVEP3 -0.44 -7.28 -0.41 3.84e-12 Lupus nephritis in systemic lupus erythematosus; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15331097 chr6:90539609 CASP8AP2 -0.49 -6.07 -0.35 4.51e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs826838 0.934 rs10875647 chr12:38856995 G/A cg13010199 chr12:38710504 ALG10B 0.6 8.53 0.46 1.18e-15 Heart rate; CESC cis rs1003719 0.688 rs2835662 chr21:38568967 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.58e-15 Eye color traits; CESC cis rs1797885 0.966 rs1619599 chr3:12504290 G/A cg26432171 chr3:12704882 RAF1 -0.5 -6.43 -0.37 5.83e-10 Immature fraction of reticulocytes; CESC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg18758796 chr5:131593413 PDLIM4 0.39 5.25 0.31 3.11e-7 Breast cancer; CESC cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg23803603 chr1:2058230 PRKCZ 0.33 5.77 0.33 2.22e-8 Height; CESC cis rs6987853 0.933 rs2974340 chr8:42397731 T/C cg09913449 chr8:42400586 C8orf40 0.39 6.13 0.35 3.15e-9 Mean corpuscular hemoglobin concentration; CESC trans rs9325144 0.554 rs1906264 chr12:38739490 A/G cg23762105 chr12:34175262 ALG10 -0.45 -6.03 -0.35 5.52e-9 Morning vs. evening chronotype; CESC cis rs7085104 0.572 rs284858 chr10:104573936 T/C cg23093090 chr10:104574429 C10orf26 0.34 5.37 0.31 1.71e-7 Immature fraction of reticulocytes;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19250579 chr3:75487529 NA -0.54 -7.21 -0.4 5.74e-12 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg22920501 chr2:26401640 FAM59B -0.64 -7.67 -0.43 3.37e-13 Gut microbiome composition (summer); CESC cis rs11690935 0.595 rs788166 chr2:172915489 G/C cg13550731 chr2:172543902 DYNC1I2 0.51 6.9 0.39 3.81e-11 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09504196 chr7:148823235 ZNF425;ZNF398 0.47 6.06 0.35 4.57e-9 Gut microbiota (bacterial taxa); CESC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg15147215 chr3:52552868 STAB1 -0.3 -5.21 -0.31 3.71e-7 Electroencephalogram traits; CESC cis rs7193541 0.564 rs4888274 chr16:74706298 A/T cg05580060 chr16:74700937 RFWD3 -0.44 -5.79 -0.34 1.99e-8 Multiple myeloma; CESC cis rs35146811 0.586 rs1076237 chr7:99585441 A/C cg22531904 chr7:99595276 NA -0.38 -5.12 -0.3 5.84e-7 Coronary artery disease; CESC cis rs1707322 0.963 rs4553121 chr1:46375253 G/A cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2439831 0.681 rs524527 chr15:43599116 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.96 -11.25 -0.57 2.93e-24 Lung cancer in ever smokers; CESC cis rs733592 0.524 rs10875744 chr12:48498440 G/C cg24011408 chr12:48396354 COL2A1 0.51 8.52 0.46 1.22e-15 Plateletcrit; CESC cis rs5758659 0.967 rs5758670 chr22:42636687 T/C cg05082376 chr22:42548792 NA -0.37 -5.45 -0.32 1.13e-7 Cognitive function; CESC cis rs2576037 0.796 rs2576034 chr18:44588548 G/A cg19077165 chr18:44547161 KATNAL2 0.54 7.47 0.42 1.14e-12 Personality dimensions; CESC cis rs2933343 0.729 rs1680786 chr3:128644840 T/C cg25356066 chr3:128598488 ACAD9 0.6 8.44 0.46 2.09e-15 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06792366 chr2:113012520 ZC3H8 -0.57 -6.62 -0.38 1.97e-10 Gut microbiome composition (summer); CESC cis rs1847505 0.559 rs1475496 chr13:61566031 G/C cg25164009 chr13:61490935 NA -0.41 -5.48 -0.32 9.91e-8 Polychlorinated biphenyl levels; CESC cis rs6714710 0.603 rs6757357 chr2:98491750 T/C cg26665480 chr2:98280029 ACTR1B 0.57 7.97 0.44 4.74e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg21951975 chr1:209979733 IRF6 -0.58 -7.53 -0.42 7.97e-13 Cleft lip with or without cleft palate; CESC cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg20307385 chr11:47447363 PSMC3 -0.5 -6.09 -0.35 4.06e-9 Subjective well-being; CESC cis rs10242455 0.614 rs2687072 chr7:99316926 A/G cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs2637266 1.000 rs11001835 chr10:78364770 A/G cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC cis rs754466 0.651 rs11818687 chr10:79637709 C/T cg17075019 chr10:79541650 NA -0.86 -12.94 -0.62 5.28e-30 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs9906944 0.624 rs2411759 chr17:47071074 C/T cg16584676 chr17:46985605 UBE2Z -0.46 -5.56 -0.32 6.74e-8 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs34172651 0.876 rs964782 chr16:24811740 T/C cg06028605 chr16:24865363 SLC5A11 0.41 6.17 0.35 2.5e-9 Intelligence (multi-trait analysis); CESC cis rs1153858 1.000 rs12101539 chr15:45650666 C/G cg21132104 chr15:45694354 SPATA5L1 0.84 11.41 0.57 8.8e-25 Homoarginine levels; CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg00369194 chr7:157950511 PTPRN2 0.31 5.06 0.3 7.87e-7 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs2710642 0.564 rs6545962 chr2:62821318 G/A cg17519650 chr2:63277830 OTX1 0.49 6.45 0.37 5.18e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs7851660 0.809 rs1561957 chr9:100670272 T/C cg13688889 chr9:100608707 NA -0.62 -8.66 -0.47 4.74e-16 Strep throat; CESC cis rs1775715 0.707 rs2808088 chr10:32146150 A/G cg18675610 chr10:32216311 ARHGAP12 0.34 5.4 0.31 1.47e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs921968 0.541 rs7601872 chr2:219319885 C/G cg02176678 chr2:219576539 TTLL4 -0.56 -9.86 -0.52 9.65e-20 Mean corpuscular hemoglobin concentration; CESC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg13607699 chr17:42295918 UBTF -0.69 -9.5 -0.5 1.35e-18 Total body bone mineral density; CESC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg10351095 chr21:47802916 PCNT -0.43 -5.51 -0.32 8.53e-8 Testicular germ cell tumor; CESC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg07701084 chr6:150067640 NUP43 0.48 6.67 0.38 1.5e-10 Lung cancer; CESC cis rs3820928 0.874 rs7421491 chr2:227839278 C/A cg11843606 chr2:227700838 RHBDD1 -0.5 -6.53 -0.37 3.36e-10 Pulmonary function; CESC cis rs796364 0.906 rs6740981 chr2:201060216 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.58 5.9 0.34 1.11e-8 Schizophrenia; CESC cis rs9291683 0.546 rs6820188 chr4:10051655 C/T cg00071950 chr4:10020882 SLC2A9 0.8 13.89 0.65 2.47e-33 Bone mineral density; CESC cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg23649088 chr2:200775458 C2orf69 0.55 5.24 0.31 3.29e-7 Schizophrenia; CESC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg14159672 chr1:205819179 PM20D1 -0.5 -6.73 -0.38 1.03e-10 Menarche (age at onset); CESC cis rs78132593 0.723 rs115291189 chr1:150675007 C/A cg22823121 chr1:150693482 HORMAD1 -0.43 -5.33 -0.31 2.13e-7 High light scatter reticulocyte count; CESC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg10351095 chr21:47802916 PCNT -0.48 -6.58 -0.37 2.46e-10 Testicular germ cell tumor; CESC trans rs7618501 1.000 rs7372725 chr3:49790544 C/A cg21659725 chr3:3221576 CRBN -0.83 -13.42 -0.64 1.08e-31 Intelligence (multi-trait analysis); CESC cis rs36051895 0.623 rs10975031 chr9:5253153 G/T cg02405213 chr9:5042618 JAK2 -0.54 -6.61 -0.38 2.16e-10 Pediatric autoimmune diseases; CESC cis rs9303401 0.527 rs7224468 chr17:56749943 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.89 0.62 7.95e-30 Cognitive test performance; CESC cis rs1355223 1.000 rs35365094 chr11:34767790 A/C cg11058730 chr11:34937778 PDHX;APIP -0.45 -5.85 -0.34 1.47e-8 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7116495 0.609 rs10751191 chr11:71680920 C/T cg10381502 chr11:71823885 C11orf51 -1.18 -7.71 -0.43 2.53e-13 Severe influenza A (H1N1) infection; CESC cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9908102 0.740 rs7211778 chr17:12901227 A/C cg26162695 chr17:12921313 ELAC2 0.53 5.93 0.34 9.61e-9 Schizophrenia; CESC cis rs7666738 0.830 rs9992639 chr4:98940400 G/T cg05340658 chr4:99064831 C4orf37 0.82 12.52 0.61 1.44e-28 Colonoscopy-negative controls vs population controls; CESC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg13628971 chr7:2884303 GNA12 0.61 7.97 0.44 4.84e-14 Height; CESC cis rs1568889 1.000 rs12804198 chr11:28143114 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 9.44 0.5 2.08e-18 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00579481 chr22:21271797 CRKL -0.43 -6.0 -0.35 6.41e-9 Gambling; CESC cis rs17023223 0.537 rs10923767 chr1:119732347 C/T cg05756136 chr1:119680316 WARS2 -0.49 -5.99 -0.35 6.86e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs7772486 0.875 rs865913 chr6:146308874 C/T cg05347473 chr6:146136440 FBXO30 0.56 7.37 0.41 2.14e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14712964 chr3:9773672 BRPF1 0.58 6.51 0.37 3.84e-10 Gut microbiome composition (summer); CESC cis rs863345 0.564 rs34701257 chr1:158480955 A/G cg12129480 chr1:158549410 OR10X1 -0.34 -6.74 -0.38 9.86e-11 Pneumococcal bacteremia; CESC cis rs7666738 0.830 rs921523 chr4:98841659 C/T cg17366294 chr4:99064904 C4orf37 0.5 6.83 0.39 5.9e-11 Colonoscopy-negative controls vs population controls; CESC cis rs7508 0.596 rs7824644 chr8:17920807 A/G cg18067069 chr8:17937731 ASAH1 -0.41 -5.36 -0.31 1.81e-7 Atrial fibrillation; CESC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg10295955 chr4:187884368 NA -1.08 -23.24 -0.82 6.56e-66 Lobe attachment (rater-scored or self-reported); CESC cis rs61931739 0.500 rs7955933 chr12:34473608 A/G cg23762105 chr12:34175262 ALG10 -0.39 -5.05 -0.3 8.28e-7 Morning vs. evening chronotype; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg15695852 chr2:43864466 PLEKHH2 -0.45 -6.48 -0.37 4.56e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs9733 0.744 rs3754211 chr1:150951857 G/A cg22823121 chr1:150693482 HORMAD1 0.36 5.17 0.3 4.58e-7 Tonsillectomy; CESC cis rs2228479 0.850 rs11646766 chr16:89838578 A/T cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg16145915 chr7:1198662 ZFAND2A -0.43 -6.1 -0.35 3.68e-9 Longevity;Endometriosis; CESC cis rs12450688 1 rs12450688 chr17:38144229 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.21 0.3 3.74e-7 Sum eosinophil basophil counts; CESC cis rs2988277 0.737 rs2949668 chr1:167434721 T/C cg09179987 chr1:167433047 CD247 0.47 7.03 0.4 1.75e-11 Allergic disease (asthma, hay fever or eczema); CESC cis rs7223966 0.921 rs7225092 chr17:61864005 G/T cg11494091 chr17:61959527 GH2 0.38 5.2 0.3 3.99e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6460942 1.000 rs2053381 chr7:12400710 C/A cg06484146 chr7:12443880 VWDE -0.69 -7.97 -0.44 4.66e-14 Coronary artery disease; CESC cis rs9513593 1.000 rs7323390 chr13:99997968 A/G cg21788972 chr13:99853209 UBAC2 0.6 6.95 0.39 2.9100000000000002e-11 Psoriasis; CESC cis rs362272 0.524 rs10937924 chr4:3374898 T/C cg14583973 chr4:3374767 RGS12 0.34 6.14 0.35 2.96e-9 Serum sulfate level; CESC cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg27398817 chr8:82754497 SNX16 -0.57 -6.5 -0.37 3.86e-10 Diastolic blood pressure; CESC cis rs7659604 1.000 rs7659943 chr4:122665560 C/T cg19671926 chr4:122722719 EXOSC9 -0.51 -6.37 -0.36 8.5e-10 Type 2 diabetes; CESC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg11764359 chr7:65958608 NA -0.8 -8.87 -0.48 1.14e-16 Aortic root size; CESC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg26119090 chr2:26468346 HADHA;HADHB -1.12 -13.53 -0.64 4.67e-32 Gut microbiome composition (summer); CESC cis rs752010 0.714 rs6664708 chr1:42083070 G/A cg06885757 chr1:42089581 HIVEP3 0.52 9.06 0.49 2.9e-17 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg25566285 chr7:158114605 PTPRN2 0.49 8.13 0.45 1.64e-14 Calcium levels; CESC cis rs6582630 0.555 rs2004152 chr12:38478951 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.64 0.55 3.12e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.7 -0.43 2.64e-13 Alzheimer's disease; CESC cis rs1023500 0.573 rs4822088 chr22:42470589 G/C cg12850546 chr22:42539477 CYP2D7P1 -0.43 -5.12 -0.3 5.88e-7 Schizophrenia; CESC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg12463550 chr7:65579703 CRCP 0.57 7.33 0.41 2.73e-12 Aortic root size; CESC cis rs12822507 0.868 rs34051318 chr12:12798338 T/C cg11838227 chr12:12764436 CREBL2 -0.41 -5.39 -0.31 1.57e-7 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.75 0.47 2.55e-16 Colonoscopy-negative controls vs population controls; CESC cis rs12545109 0.800 rs1440746 chr8:57415912 G/A cg09654669 chr8:57350985 NA -0.45 -6.21 -0.36 2.01e-9 Obesity-related traits; CESC cis rs7100689 0.784 rs3802637 chr10:82179699 G/C cg00277334 chr10:82204260 NA -0.61 -7.42 -0.41 1.57e-12 Post bronchodilator FEV1; CESC cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg04398451 chr17:18023971 MYO15A 0.44 5.35 0.31 1.89e-7 Body mass index; CESC cis rs250677 1.000 rs250676 chr5:148425518 A/T cg18129178 chr5:148520854 ABLIM3 -0.47 -5.57 -0.32 6.38e-8 Breast cancer; CESC cis rs2243480 1.000 rs73150014 chr7:65450919 A/C cg25894440 chr7:65020034 NA -0.66 -5.69 -0.33 3.42e-8 Diabetic kidney disease; CESC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg18876405 chr7:65276391 NA 0.44 6.12 0.35 3.34e-9 Aortic root size; CESC cis rs2180341 0.782 rs6912552 chr6:127722946 C/G cg27446573 chr6:127587934 RNF146 -0.77 -11.16 -0.57 5.7e-24 Breast cancer; CESC cis rs9913156 0.793 rs55782417 chr17:4562845 G/A cg00122941 chr17:4613640 ARRB2 0.85 9.99 0.52 3.79e-20 Lymphocyte counts; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05602567 chr22:32871203 FBXO7 -0.45 -6.0 -0.35 6.35e-9 Asthma; CESC cis rs17253792 0.822 rs28481586 chr14:56053863 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.83 6.03 0.35 5.45e-9 Putamen volume; CESC cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 6.52 0.37 3.44e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg08027265 chr7:2291960 NA -0.36 -5.47 -0.32 1.05e-7 Bipolar disorder and schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09273779 chr9:35605990 TESK1 0.51 6.68 0.38 1.42e-10 Gut microbiota (bacterial taxa); CESC cis rs12681288 0.862 rs7015529 chr8:1020249 A/G cg04851639 chr8:1020857 NA -0.39 -8.41 -0.46 2.62e-15 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01905589 chr1:26856408 RPS6KA1 -0.47 -6.15 -0.35 2.86e-9 Ulcerative colitis; CESC cis rs9467773 1.000 rs9467791 chr6:26562486 A/G cg24633756 chr6:26577808 NA -0.35 -5.39 -0.31 1.55e-7 Intelligence (multi-trait analysis); CESC cis rs9640161 0.750 rs3735169 chr7:150034378 A/G cg10018233 chr7:150070692 REPIN1 0.46 6.86 0.39 4.92e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs698833 0.886 rs698824 chr2:44723123 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 6.47 0.37 4.77e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs2549003 1.000 rs2706384 chr5:131826880 G/T cg00255919 chr5:131827918 IRF1 -0.58 -10.12 -0.53 1.41e-20 Asthma (sex interaction); CESC cis rs367943 1.000 rs348958 chr5:112821137 G/A cg12552261 chr5:112820674 MCC -0.64 -8.05 -0.44 2.83e-14 Type 2 diabetes; CESC cis rs7474896 0.522 rs117157955 chr10:37984164 G/T cg00409905 chr10:38381863 ZNF37A -0.45 -5.15 -0.3 4.98e-7 Obesity (extreme); CESC cis rs262150 0.574 rs2730272 chr7:158798622 G/C cg19418458 chr7:158789849 NA -0.41 -6.45 -0.37 5.28e-10 Facial morphology (factor 20); CESC cis rs11711311 1.000 rs921741 chr3:113444051 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.57 7.56 0.42 6.49e-13 IgG glycosylation; CESC cis rs4268898 0.965 rs4665673 chr2:24459737 A/T cg06627628 chr2:24431161 ITSN2 0.66 8.01 0.44 3.69e-14 Asthma; CESC cis rs11958404 0.932 rs6865373 chr5:157436728 A/G cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs2073300 1.000 rs6048811 chr20:23446719 G/C cg12062639 chr20:23401060 NAPB 0.74 5.43 0.32 1.3e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs56104184 0.723 rs73063515 chr19:49407715 C/T cg15549821 chr19:49342101 PLEKHA4 -0.57 -5.76 -0.33 2.33e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs35365539 1 rs35365539 chr3:49794347 A/AC cg24308560 chr3:49941425 MST1R 0.51 6.99 0.39 2.28e-11 Blood protein levels; CESC cis rs4808199 0.947 rs4808960 chr19:19574277 G/C cg03709012 chr19:19516395 GATAD2A 1.17 13.38 0.63 1.53e-31 Nonalcoholic fatty liver disease; CESC cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg01579765 chr21:45077557 HSF2BP 0.52 8.97 0.48 5.48e-17 Mean corpuscular volume; CESC cis rs3738443 0.569 rs6704060 chr1:247381524 C/T cg07706540 chr1:247373924 NA -0.47 -5.67 -0.33 3.63e-8 Alcohol dependence; CESC cis rs1023500 0.596 rs5751209 chr22:42451603 A/G cg04733989 chr22:42467013 NAGA 0.8 11.04 0.56 1.44e-23 Schizophrenia; CESC cis rs9309473 0.500 rs10189578 chr2:73728609 C/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.86 -0.39 4.92e-11 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10592546 chr5:180649562 TRIM41 0.53 6.02 0.35 5.73e-9 Gut microbiome composition (summer); CESC cis rs926392 0.666 rs56877916 chr20:37696192 A/T cg16355469 chr20:37678765 NA 0.53 5.86 0.34 1.36e-8 Dialysis-related mortality; CESC cis rs10782582 0.569 rs74090722 chr1:76197262 A/G cg10523679 chr1:76189770 ACADM -0.49 -5.79 -0.33 2.02e-8 Daytime sleep phenotypes; CESC cis rs4810479 0.513 rs3746506 chr20:44586036 G/A cg27529037 chr20:44575021 PCIF1 0.43 6.33 0.36 1.06e-9 Metabolite levels; CESC cis rs6831352 0.879 rs2602879 chr4:100040652 G/A cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Alcohol dependence; CESC cis rs4454254 0.966 rs4631439 chr8:141059650 C/T cg06693505 chr8:141057453 TRAPPC9 -0.35 -5.74 -0.33 2.57e-8 Pulse pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23682824 chr7:23144976 KLHL7 -0.62 -7.04 -0.4 1.66e-11 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06614436 chr3:179065438 MFN1 -0.52 -6.18 -0.35 2.38e-9 Ulcerative colitis; CESC cis rs7508679 1.000 rs7248104 chr19:7224431 A/G cg09779027 chr19:7224513 INSR 0.59 9.45 0.5 1.81e-18 Hypothyroidism; CESC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.64 0.38 1.81e-10 Bipolar disorder; CESC cis rs17253792 0.749 rs74979160 chr14:56097568 G/A cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs6964587 0.967 rs10231496 chr7:91741132 T/C cg17063962 chr7:91808500 NA 0.54 7.58 0.42 5.65e-13 Breast cancer; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03406422 chr11:77850844 ALG8 0.46 6.03 0.35 5.56e-9 Intelligence (multi-trait analysis); CESC trans rs1814175 0.615 rs12417290 chr11:49876951 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.27 -0.36 1.42e-9 Height; CESC cis rs11048434 0.636 rs7306165 chr12:9059081 T/C cg23795048 chr12:9217529 LOC144571 0.32 5.03 0.3 8.89e-7 Sjögren's syndrome; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07640473 chr3:50193232 SEMA3F -0.47 -7.16 -0.4 7.98e-12 Gut microbiota (bacterial taxa); CESC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg02807482 chr3:125708958 NA -0.37 -5.18 -0.3 4.5e-7 Blood pressure (smoking interaction); CESC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs67478160 0.643 rs8005225 chr14:104300151 C/T cg01849466 chr14:104193079 ZFYVE21 0.51 7.2 0.4 6.29e-12 Schizophrenia; CESC cis rs7527798 0.544 rs11118354 chr1:207856868 A/G cg21110645 chr1:207815933 NA -0.33 -5.86 -0.34 1.33e-8 Erythrocyte sedimentation rate; CESC trans rs61931739 0.500 rs11053194 chr12:34440841 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.5 0.42 9.79e-13 Morning vs. evening chronotype; CESC cis rs60843830 1.000 rs60149603 chr2:285421 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.78 9.99 0.52 3.67e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs1814175 0.647 rs2903409 chr11:49953612 C/G cg15704280 chr7:45808275 SEPT13 -0.82 -11.47 -0.58 5.18e-25 Height; CESC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg23161317 chr6:28129485 ZNF389 0.47 5.88 0.34 1.21e-8 Depression; CESC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC cis rs300703 0.719 rs385272 chr2:206704 A/G cg21211680 chr2:198530 NA -0.94 -10.26 -0.53 4.97e-21 Blood protein levels; CESC cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg24110177 chr3:50126178 RBM5 0.51 6.95 0.39 2.77e-11 Intelligence (multi-trait analysis); CESC cis rs2730245 0.851 rs2657333 chr7:158728743 G/A cg24397884 chr7:158709396 WDR60 -0.88 -13.46 -0.64 7.72e-32 Height; CESC cis rs6458375 1.000 rs6916554 chr6:44204736 T/A cg02172915 chr6:44211962 NA 0.47 5.34 0.31 2.04e-7 Interleukin-10 levels; CESC cis rs72781680 0.898 rs72781639 chr2:24204148 C/G cg08917208 chr2:24149416 ATAD2B 0.92 8.28 0.45 6.31e-15 Lymphocyte counts; CESC cis rs9611565 0.546 rs5758426 chr22:42098763 T/G cg06481639 chr22:41940642 POLR3H 0.45 5.15 0.3 5.13e-7 Vitiligo; CESC trans rs7142881 0.508 rs1954441 chr14:32118713 A/G cg08127348 chr19:17448311 GTPBP3 -0.44 -6.06 -0.35 4.64e-9 Response to iloperidone treatment (QT prolongation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02396040 chr6:88117726 C6orf165 0.56 6.24 0.36 1.69e-9 Gut microbiome composition (summer); CESC trans rs7672847 0.547 rs58602886 chr4:170427848 G/A cg19308436 chr1:237949471 RYR2 0.61 6.44 0.37 5.7e-10 Subjective well-being; CESC cis rs72627123 0.867 rs8015927 chr14:74465756 A/T cg12022184 chr14:74485813 ENTPD5;C14orf45 -0.75 -5.68 -0.33 3.61e-8 Morning vs. evening chronotype; CESC cis rs295137 0.799 rs4145969 chr2:201139961 C/T cg23649088 chr2:200775458 C2orf69 -0.44 -5.9 -0.34 1.11e-8 Asthma (bronchodilator response); CESC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg18876405 chr7:65276391 NA -0.53 -7.39 -0.41 1.96e-12 Aortic root size; CESC cis rs7659604 0.502 rs13128434 chr4:122672461 A/C cg19671926 chr4:122722719 EXOSC9 0.58 7.34 0.41 2.66e-12 Type 2 diabetes; CESC cis rs8005677 0.828 rs35085068 chr14:23409909 C/A cg01529538 chr14:23388837 RBM23 0.44 5.83 0.34 1.63e-8 Cognitive ability (multi-trait analysis); CESC cis rs2295359 0.892 rs10889657 chr1:67615487 A/G cg17031739 chr1:67600172 NA 0.39 5.2 0.3 3.91e-7 Psoriasis; CESC cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg13175981 chr1:150552382 MCL1 0.75 11.23 0.57 3.32e-24 Tonsillectomy; CESC cis rs4423214 1.000 rs28364617 chr11:71159764 T/G cg05163923 chr11:71159392 DHCR7 0.85 12.11 0.6 3.72e-27 Vitamin D levels; CESC cis rs2204008 0.806 rs7305409 chr12:38349133 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.65 0.55 2.87e-22 Bladder cancer; CESC cis rs17039065 0.920 rs1595197 chr4:109472301 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.71 6.16 0.35 2.74e-9 Gut microbiome composition (summer); CESC cis rs13102973 0.931 rs13134190 chr4:135854932 T/C cg14419869 chr4:135874104 NA 0.33 5.16 0.3 4.75e-7 Subjective well-being; CESC trans rs17125944 0.506 rs7151491 chr14:53313711 C/G cg01134794 chr4:78529898 CXCL13 0.54 6.09 0.35 3.9e-9 Alzheimer's disease (late onset); CESC cis rs2952156 0.920 rs11078919 chr17:37835755 T/C cg07936489 chr17:37558343 FBXL20 -0.59 -7.77 -0.43 1.68e-13 Asthma; CESC cis rs61542988 0.570 rs62448268 chr7:22829464 G/A cg11367502 chr7:22862612 TOMM7 0.54 6.42 0.37 6.32e-10 Fibrinogen levels; CESC cis rs11864453 0.645 rs7194668 chr16:72128207 G/C cg01557791 chr16:72042693 DHODH -0.45 -5.46 -0.32 1.08e-7 Fibrinogen levels; CESC cis rs644799 1.000 rs12291986 chr11:95523030 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 6.41 0.37 6.47e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6504663 0.525 rs557 chr17:48563234 C/T cg03168497 chr17:48586147 MYCBPAP 0.46 5.44 0.32 1.21e-7 Visceral fat; CESC cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.44 0.32 1.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1568889 1.000 rs16917689 chr11:28064466 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.83 0.55 7.35e-23 Bipolar disorder; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg08429943 chr16:29606618 NA -0.51 -6.22 -0.36 1.91e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs7772486 0.754 rs9386132 chr6:146140751 T/C cg05347473 chr6:146136440 FBXO30 0.57 7.29 0.41 3.56e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs8077889 1.000 rs17674998 chr17:41879544 A/G cg26893861 chr17:41843967 DUSP3 0.7 8.21 0.45 1.01e-14 Triglycerides; CESC cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg20573242 chr4:122745356 CCNA2 0.63 8.17 0.45 1.24e-14 Type 2 diabetes; CESC cis rs7267979 1.000 rs4815411 chr20:25350223 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.41 -0.75 2.65e-49 Liver enzyme levels (alkaline phosphatase); CESC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg07930192 chr7:1003750 NA 0.42 5.71 0.33 3.02e-8 Longevity;Endometriosis; CESC trans rs2361710 0.611 rs12451471 chr17:78102517 C/T cg00575896 chr3:50357171 HYAL2 -0.39 -6.03 -0.35 5.49e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CESC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg16680214 chr1:154839983 KCNN3 -0.45 -6.79 -0.39 7.19e-11 Prostate cancer; CESC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg22963979 chr7:1858916 MAD1L1 -0.39 -5.29 -0.31 2.59e-7 Bipolar disorder and schizophrenia; CESC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg00784671 chr22:46762841 CELSR1 -0.48 -5.59 -0.32 5.72e-8 LDL cholesterol;Cholesterol, total; CESC cis rs3747547 0.710 rs7863948 chr9:37949409 A/C cg13774184 chr9:37916125 SHB -0.57 -5.83 -0.34 1.57e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs12477438 0.798 rs2123686 chr2:99690135 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg03467027 chr4:99064603 C4orf37 0.43 5.39 0.31 1.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg19592336 chr6:28129416 ZNF389 0.59 7.78 0.43 1.63e-13 Depression; CESC trans rs10435719 0.773 rs7842810 chr8:11794163 A/G cg15556689 chr8:8085844 FLJ10661 0.51 6.32 0.36 1.1e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CESC trans rs9325144 0.650 rs6582631 chr12:38744135 T/C cg23762105 chr12:34175262 ALG10 -0.48 -6.46 -0.37 4.99e-10 Morning vs. evening chronotype; CESC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg02935154 chr7:12443704 VWDE -0.6 -6.82 -0.39 6.02e-11 Coronary artery disease; CESC cis rs9911578 1.000 rs7342903 chr17:56914588 C/G cg12560992 chr17:57184187 TRIM37 0.94 15.75 0.7 6.57e-40 Intelligence (multi-trait analysis); CESC cis rs8060686 0.623 rs2418736 chr16:68154862 A/G cg26727032 chr16:67993705 SLC12A4 0.58 8.72 0.47 3.02e-16 HDL cholesterol;Metabolic syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06539400 chr16:4365605 NA 0.58 6.55 0.37 3.03e-10 Gut microbiome composition (summer); CESC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg22307029 chr19:49891270 CCDC155 0.69 8.11 0.45 1.92e-14 Multiple sclerosis; CESC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.65 0.38 1.71e-10 Prudent dietary pattern; CESC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg00990874 chr7:1149470 C7orf50 -0.46 -5.08 -0.3 7.21e-7 Bronchopulmonary dysplasia; CESC cis rs7855088 1.000 rs1572025 chr9:100741115 A/C cg13688889 chr9:100608707 NA -0.38 -5.72 -0.33 2.94e-8 Serum thyroid-stimulating hormone levels; CESC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg18446336 chr7:2847575 GNA12 -0.38 -5.76 -0.33 2.28e-8 Height; CESC cis rs4704187 0.687 rs4621537 chr5:74362222 A/G cg03227963 chr5:74354835 NA 0.31 5.71 0.33 2.97e-8 Response to amphetamines; CESC cis rs3782123 0.539 rs10902111 chr11:241489 C/T cg00562011 chr11:252351 PSMD13 0.67 5.59 0.32 5.72e-8 Glycated hemoglobin levels;Red cell distribution width; CESC cis rs11098499 0.954 rs12507964 chr4:120413061 T/A cg24375607 chr4:120327624 NA 0.46 5.63 0.33 4.52e-8 Corneal astigmatism; CESC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg02569458 chr12:86230093 RASSF9 0.51 7.7 0.43 2.65e-13 Major depressive disorder; CESC cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg07636037 chr3:49044803 WDR6 1.05 18.53 0.75 9.5e-50 Parkinson's disease; CESC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg10691866 chr7:65817282 TPST1 -0.32 -5.33 -0.31 2.07e-7 Aortic root size; CESC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg02931644 chr1:25747376 RHCE 0.41 6.66 0.38 1.54e-10 Erythrocyte sedimentation rate; CESC cis rs7084402 0.967 rs12259990 chr10:60297574 A/G cg07615347 chr10:60278583 BICC1 -0.57 -8.56 -0.47 9.58e-16 Refractive error; CESC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg24060327 chr5:131705240 SLC22A5 -0.75 -10.06 -0.53 2.31e-20 Breast cancer; CESC cis rs7762018 1.000 rs73242910 chr6:170114670 A/G cg05834625 chr6:170176447 C6orf70 0.64 7.53 0.42 7.96e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9894429 0.809 rs9889642 chr17:79591762 T/C cg18240062 chr17:79603768 NPLOC4 0.73 10.23 0.53 6.51e-21 Eye color traits; CESC cis rs477692 0.571 rs10764890 chr10:131347163 G/A cg05714579 chr10:131428358 MGMT 0.43 5.78 0.33 2.1e-8 Response to temozolomide; CESC cis rs11098499 0.604 rs17051352 chr4:120581427 G/A cg24375607 chr4:120327624 NA 0.45 5.46 0.32 1.08e-7 Corneal astigmatism; CESC cis rs4423214 0.802 rs4402322 chr11:71184015 C/G cg05163923 chr11:71159392 DHCR7 -0.68 -7.76 -0.43 1.82e-13 Vitamin D levels; CESC cis rs11098499 0.866 rs6857892 chr4:120282696 G/T cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg22823121 chr1:150693482 HORMAD1 0.38 5.58 0.32 5.92e-8 Melanoma; CESC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg05368731 chr17:41323189 NBR1 0.76 10.4 0.54 1.76e-21 Menopause (age at onset); CESC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9788682 0.947 rs7169584 chr15:78822660 A/T cg06917634 chr15:78832804 PSMA4 -0.56 -6.68 -0.38 1.38e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24590075 chr17:40224031 NA -0.54 -6.16 -0.35 2.74e-9 Gut microbiome composition (summer); CESC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg10150615 chr22:24372951 LOC391322 -0.59 -7.93 -0.44 6.07e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21659725 chr3:3221576 CRBN 0.83 13.56 0.64 3.67e-32 Intelligence (multi-trait analysis); CESC cis rs3916 0.794 rs3021337 chr12:121163261 C/T cg21892295 chr12:121157589 UNC119B -0.4 -6.31 -0.36 1.14e-9 Urinary metabolites (H-NMR features); CESC cis rs6831352 0.918 rs2602891 chr4:100043284 C/T cg12011299 chr4:100065546 ADH4 0.59 6.58 0.37 2.55e-10 Alcohol dependence; CESC cis rs10751667 0.643 rs7394436 chr11:970373 G/C cg06064525 chr11:970664 AP2A2 -0.47 -9.13 -0.49 1.87e-17 Alzheimer's disease (late onset); CESC cis rs72781680 0.846 rs72780198 chr2:24014883 T/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs9815354 0.680 rs79239400 chr3:42030249 C/A cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs11864453 0.826 rs6499560 chr16:72147666 G/T cg16558253 chr16:72132732 DHX38 0.61 9.75 0.51 2.2e-19 Fibrinogen levels; CESC cis rs938554 0.612 rs13113918 chr4:9998493 A/G cg11266682 chr4:10021025 SLC2A9 0.47 6.54 0.37 3.22e-10 Blood metabolite levels; CESC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg08109568 chr15:31115862 NA -0.71 -9.5 -0.5 1.29e-18 Huntington's disease progression; CESC cis rs8141529 0.509 rs6005927 chr22:29255884 A/G cg15103426 chr22:29168792 CCDC117 0.63 8.32 0.45 4.8e-15 Lymphocyte counts; CESC cis rs2832077 0.527 rs9980449 chr21:30224889 G/C cg24692254 chr21:30365293 RNF160 -0.66 -9.15 -0.49 1.56e-17 Cognitive test performance; CESC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg20151795 chr6:28129481 ZNF389 0.45 5.92 0.34 9.77e-9 Depression; CESC cis rs6598955 0.670 rs7520517 chr1:26556385 A/C cg00852783 chr1:26633632 UBXN11 0.43 6.4 0.37 6.97e-10 Obesity-related traits; CESC trans rs1814175 0.676 rs11040647 chr11:49935947 A/C cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs11098499 0.866 rs72676074 chr4:120359841 A/C cg24375607 chr4:120327624 NA 0.45 5.6 0.33 5.42e-8 Corneal astigmatism; CESC cis rs1348850 0.801 rs11890163 chr2:178327134 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 5.38 0.31 1.66e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs910316 1.000 rs4899544 chr14:75546556 C/T cg11812906 chr14:75593930 NEK9 0.89 15.23 0.68 4.57e-38 Height; CESC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg03806693 chr22:41940476 POLR3H 1.16 13.59 0.64 2.85e-32 Vitiligo; CESC cis rs12249377 0.519 rs12259060 chr10:92579949 A/G cg14313238 chr10:92632228 RPP30 0.42 5.05 0.3 8.05e-7 White matter microstructure (global fractional anisotropy); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09755102 chr1:33283495 S100PBP;YARS 0.52 6.85 0.39 5.14e-11 Gut microbiota (bacterial taxa); CESC cis rs35995292 0.500 rs6945239 chr7:38932208 C/T cg19327137 chr7:38886074 VPS41 0.67 11.01 0.56 1.76e-23 Subjective well-being (multi-trait analysis); CESC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg19592336 chr6:28129416 ZNF389 0.49 6.85 0.39 5.12e-11 Parkinson's disease; CESC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg11890956 chr21:40555474 PSMG1 1.2 22.3 0.81 9.49e-63 Cognitive function; CESC cis rs67311347 0.955 rs11711994 chr3:40391086 T/C cg24209194 chr3:40518798 ZNF619 0.49 5.98 0.34 7.39e-9 Renal cell carcinoma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21080633 chr12:132263633 SFRS8 0.52 6.73 0.38 1.04e-10 Fibrinogen levels; CESC cis rs10129255 0.518 rs11847766 chr14:107187425 T/C cg07958169 chr14:107095056 NA -0.55 -8.65 -0.47 4.94e-16 Kawasaki disease; CESC cis rs9291683 0.679 rs13137795 chr4:10051506 G/A cg11266682 chr4:10021025 SLC2A9 0.66 13.03 0.62 2.6e-30 Bone mineral density; CESC cis rs9790314 1.000 rs336593 chr3:161076431 T/C cg04691961 chr3:161091175 C3orf57 -0.41 -5.3 -0.31 2.44e-7 Morning vs. evening chronotype; CESC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg22963979 chr7:1858916 MAD1L1 -0.43 -5.87 -0.34 1.31e-8 Bipolar disorder and schizophrenia; CESC cis rs7917772 0.582 rs729024 chr10:104341975 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 5.71 0.33 3.01e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7786877 0.583 rs41303510 chr7:100226129 C/T cg16850897 chr7:100343110 ZAN -0.62 -6.63 -0.38 1.9e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs28374715 0.532 rs7168431 chr15:41672384 A/G cg18705301 chr15:41695430 NDUFAF1 -1.08 -17.7 -0.74 8.28e-47 Ulcerative colitis; CESC cis rs12136530 0.774 rs904966 chr1:19772177 G/C cg01832549 chr1:19774989 CAPZB -0.48 -6.91 -0.39 3.65e-11 Lead levels in blood; CESC cis rs13256369 0.802 rs13280101 chr8:8562773 G/A cg18904891 chr8:8559673 CLDN23 0.7 7.74 0.43 2.1e-13 Obesity-related traits; CESC cis rs3754214 0.823 rs10888579 chr1:150261925 C/T cg09579323 chr1:150459698 TARS2 -0.46 -5.74 -0.33 2.58e-8 Cerebrospinal fluid biomarker levels; CESC cis rs2154427 0.938 rs2833967 chr21:34191308 G/A cg21871883 chr21:34145043 C21orf49;C21orf66 0.62 5.12 0.3 5.81e-7 Bilirubin levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15544184 chr11:49872191 NA -0.33 -6.3 -0.36 1.26e-9 Asthma; CESC cis rs2562152 0.515 rs2562176 chr16:146487 G/C cg02949481 chr16:131562 MPG 0.74 7.38 0.41 2.08e-12 Glioblastoma; CESC cis rs6942756 1.000 rs11769045 chr7:128895335 A/G cg02491457 chr7:128862824 NA -0.7 -9.97 -0.52 4.48e-20 White matter hyperintensity burden; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19900852 chr14:35451793 SRP54 0.56 6.53 0.37 3.25e-10 Gut microbiome composition (summer); CESC cis rs36051895 0.632 rs10758674 chr9:5163645 G/A cg02405213 chr9:5042618 JAK2 -0.5 -6.29 -0.36 1.27e-9 Pediatric autoimmune diseases; CESC cis rs10170846 0.893 rs10932967 chr2:223544111 C/T cg25565276 chr2:223520875 FARSB 0.57 7.86 0.43 9.85e-14 Schizophrenia (inflammation and infection response interaction); CESC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -8.14 -0.45 1.54e-14 Developmental language disorder (linguistic errors); CESC cis rs17376456 0.877 rs12153788 chr5:93405437 A/G cg21475434 chr5:93447410 FAM172A 0.82 7.28 0.41 3.91e-12 Diabetic retinopathy; CESC trans rs7985867 0.645 rs471864 chr13:26032843 G/C cg26929337 chr19:52511726 ZNF615 0.44 6.07 0.35 4.32e-9 Common carotid intima-media thickness; CESC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg09455208 chr3:40491958 NA 0.51 8.55 0.47 9.79e-16 Renal cell carcinoma; CESC cis rs7520050 0.966 rs1085244 chr1:46563680 C/A cg24296786 chr1:45957014 TESK2 0.41 5.17 0.3 4.63e-7 Red blood cell count;Reticulocyte count; CESC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg06481639 chr22:41940642 POLR3H 0.59 5.85 0.34 1.45e-8 Crohn's disease;Inflammatory bowel disease; CESC trans rs61931739 0.500 rs6416261 chr12:34540377 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.74e-12 Morning vs. evening chronotype; CESC cis rs6089584 1.000 rs3787425 chr20:60559256 C/T cg24733560 chr20:60626293 TAF4 0.4 5.77 0.33 2.15e-8 Body mass index; CESC cis rs4595586 0.525 rs73096109 chr12:39355720 C/A cg26384229 chr12:38710491 ALG10B 0.63 8.79 0.48 1.9e-16 Morning vs. evening chronotype; CESC cis rs7607369 0.526 rs4674322 chr2:219513782 C/T cg02176678 chr2:219576539 TTLL4 0.44 5.46 0.32 1.1e-7 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs7937682 1.000 rs11608122 chr11:111535105 C/T cg09085632 chr11:111637200 PPP2R1B 1.02 14.04 0.65 7.45e-34 Primary sclerosing cholangitis; CESC cis rs208520 0.690 rs12192851 chr6:66705862 G/C cg07460842 chr6:66804631 NA 0.97 13.24 0.63 4.76e-31 Exhaled nitric oxide output; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg18986332 chr3:33759647 CLASP2 0.41 6.06 0.35 4.75e-9 Vertical cup-disc ratio; CESC trans rs7726839 0.540 rs3792720 chr5:643028 T/G cg25482853 chr8:67687455 SGK3 0.93 9.65 0.51 4.47e-19 Obesity-related traits; CESC cis rs7937682 0.889 rs7926485 chr11:111536670 G/A cg09085632 chr11:111637200 PPP2R1B -0.99 -16.33 -0.71 5.97e-42 Primary sclerosing cholangitis; CESC trans rs748404 0.631 rs3809482 chr15:43661802 T/C cg24053811 chr14:70265306 SLC10A1 0.42 6.0 0.35 6.55e-9 Lung cancer; CESC cis rs11122272 0.735 rs2491410 chr1:231532287 C/T cg06096015 chr1:231504339 EGLN1 0.41 5.81 0.34 1.74e-8 Hemoglobin concentration; CESC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg03806693 chr22:41940476 POLR3H 1.16 13.59 0.64 2.85e-32 Vitiligo; CESC cis rs6545883 0.859 rs62149714 chr2:61603869 T/G cg15711740 chr2:61764176 XPO1 0.4 5.1 0.3 6.53e-7 Tuberculosis; CESC cis rs9905704 0.846 rs304267 chr17:56799380 A/G cg12560992 chr17:57184187 TRIM37 0.62 7.78 0.43 1.6e-13 Testicular germ cell tumor; CESC cis rs12477438 0.520 rs11695379 chr2:99742161 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.11 0.7 3.54e-41 Chronic sinus infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16636692 chr6:27115249 HIST1H2BK;HIST1H2AH -0.52 -6.78 -0.38 7.75e-11 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13272430 chr14:67708475 MPP5 0.57 6.09 0.35 3.89e-9 Gut microbiome composition (summer); CESC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg17340268 chr14:105411764 AHNAK2 -0.51 -6.84 -0.39 5.32e-11 Rheumatoid arthritis; CESC cis rs10463316 0.817 rs6877498 chr5:150802876 C/T cg03212797 chr5:150827313 SLC36A1 -0.48 -6.2 -0.36 2.21e-9 Metabolite levels (Pyroglutamine); CESC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg18402987 chr7:1209562 NA 0.76 7.56 0.42 6.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17293817 0.617 rs12775843 chr10:1412326 T/C cg04271617 chr10:1416546 ADARB2 0.33 5.03 0.3 8.84e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs1728785 0.818 rs12926059 chr16:68569459 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.43 0.42 1.5e-12 Ulcerative colitis; CESC cis rs698833 0.852 rs2582918 chr2:44582275 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.55 6.9 0.39 3.72e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg11905131 chr22:24372483 LOC391322 -0.8 -12.13 -0.6 3.08e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs992157 0.798 rs1017698 chr2:219170525 A/G cg00012203 chr2:219082015 ARPC2 -0.75 -10.2 -0.53 8.03e-21 Colorectal cancer; CESC cis rs8067354 0.574 rs1292035 chr17:57989557 G/A cg13753209 chr17:57696993 CLTC 0.54 5.69 0.33 3.36e-8 Hemoglobin concentration; CESC cis rs2072732 0.861 rs10909867 chr1:2961402 G/T cg15211996 chr1:2936768 ACTRT2 0.35 5.87 0.34 1.31e-8 Plateletcrit; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27284088 chr4:84031130 PLAC8 -0.43 -6.18 -0.35 2.36e-9 Gambling; CESC cis rs12413816 0.517 rs4750400 chr10:13765923 A/G cg16485048 chr10:13749193 FRMD4A 0.43 5.94 0.34 8.88e-9 Red cell distribution width; CESC cis rs7312933 1.000 rs12372597 chr12:42412850 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.42 5.46 0.32 1.09e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg06212747 chr3:49208901 KLHDC8B 0.67 8.99 0.48 4.66e-17 Parkinson's disease; CESC cis rs9815354 0.680 rs17218936 chr3:42019392 C/T cg03022575 chr3:42003672 ULK4 0.74 6.64 0.38 1.79e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs4065321 0.522 rs11078930 chr17:38141955 C/T cg17467752 chr17:38218738 THRA -0.44 -5.81 -0.34 1.76e-8 White blood cell count (basophil);White blood cell count; CESC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.69 -0.33 3.38e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2120019 1.000 rs60425110 chr15:75333000 T/A cg09165964 chr15:75287851 SCAMP5 -0.78 -9.31 -0.5 5.05e-18 Blood trace element (Zn levels); CESC cis rs7949030 0.588 rs2509961 chr11:62310909 T/C cg02375832 chr11:62437615 C11orf48 -0.36 -5.34 -0.31 1.98e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs8078723 0.966 rs57968500 chr17:38145828 A/G cg17467752 chr17:38218738 THRA 0.68 10.22 0.53 6.77e-21 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs7727544 0.735 rs2569266 chr5:131706791 T/C cg07395648 chr5:131743802 NA 0.43 5.71 0.33 2.96e-8 Blood metabolite levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06766273 chr11:62521983 ZBTB3 0.47 6.24 0.36 1.69e-9 Systemic lupus erythematosus; CESC cis rs8038465 0.622 rs2509 chr15:73859488 A/T cg15420318 chr15:73925796 NPTN -0.45 -6.23 -0.36 1.8e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2280018 0.538 rs7404526 chr16:15129162 A/G cg07549590 chr16:15018862 NA -0.54 -8.81 -0.48 1.71e-16 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs3820928 0.934 rs4675117 chr2:227769794 A/G cg05526886 chr2:227700861 RHBDD1 0.47 5.72 0.33 2.84e-8 Pulmonary function; CESC cis rs864745 0.600 rs849327 chr7:28232457 A/G cg23620719 chr7:28220237 JAZF1 -0.43 -5.1 -0.3 6.62e-7 Crohn's disease;Type 2 diabetes; CESC cis rs10927875 0.691 rs1048261 chr1:16340951 A/T cg21385522 chr1:16154831 NA 0.62 7.44 0.42 1.39e-12 Dilated cardiomyopathy; CESC cis rs6831352 0.959 rs6848050 chr4:100053733 T/C cg21548116 chr4:100009993 ADH5 0.48 5.09 0.3 6.72e-7 Alcohol dependence; CESC trans rs7132746 0.620 rs61928911 chr12:86195973 A/G cg06215984 chr1:203258903 NA -0.56 -6.16 -0.35 2.64e-9 Lewy body disease; CESC cis rs9640161 0.658 rs74348353 chr7:150053655 C/A cg17279839 chr7:150038598 RARRES2 0.45 5.43 0.32 1.3e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg24675658 chr1:53192096 ZYG11B -0.65 -8.83 -0.48 1.43e-16 Monocyte count; CESC cis rs7267979 1.000 rs4815420 chr20:25383979 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -17.74 -0.74 6.08e-47 Liver enzyme levels (alkaline phosphatase); CESC cis rs6754311 0.861 rs12475139 chr2:136786651 A/T cg07169764 chr2:136633963 MCM6 0.62 7.91 0.44 7.19e-14 Mosquito bite size; CESC cis rs748404 0.660 rs2467742 chr15:43750237 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.56 0.42 6.43e-13 Lung cancer; CESC cis rs2455799 0.552 rs2470519 chr3:15762847 G/A cg16303742 chr3:15540471 COLQ -0.39 -6.24 -0.36 1.76e-9 Mean platelet volume; CESC cis rs4654899 0.865 rs7532667 chr1:21438239 A/G cg05370193 chr1:21551575 ECE1 0.43 6.87 0.39 4.69e-11 Superior frontal gyrus grey matter volume; CESC cis rs1008375 1.000 rs1860597 chr4:17657650 C/T cg16339924 chr4:17578868 LAP3 0.55 6.93 0.39 3.22e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6121246 0.559 rs12479491 chr20:30265450 T/C cg13852791 chr20:30311386 BCL2L1 0.8 10.41 0.54 1.72e-21 Mean corpuscular hemoglobin; CESC cis rs2404602 0.716 rs67204011 chr15:76846555 C/T cg26408565 chr15:76604113 ETFA -0.4 -5.82 -0.34 1.71e-8 Blood metabolite levels; CESC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg14562523 chr21:43528734 C21orf128;UMODL1 -0.39 -5.82 -0.34 1.67e-8 IgG glycosylation; CESC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg20271620 chr17:80763330 TBCD 0.44 5.16 0.3 4.79e-7 Breast cancer; CESC cis rs72945132 0.714 rs117232799 chr11:70157182 G/A cg00319359 chr11:70116639 PPFIA1 0.75 6.21 0.36 2.06e-9 Coronary artery disease; CESC cis rs4332037 0.851 rs73050128 chr7:1961882 C/A cg23422044 chr7:1970798 MAD1L1 -0.57 -5.99 -0.35 6.71e-9 Bipolar disorder; CESC cis rs1372520 0.684 rs356162 chr4:90697157 T/C cg15133208 chr4:90757351 SNCA 0.42 5.4 0.31 1.5e-7 Neuroticism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03005121 chr22:46933669 CELSR1 0.45 6.0 0.35 6.56e-9 Fibrinogen levels; CESC cis rs67257959 0.586 rs111818766 chr19:17158092 G/A cg16202187 chr19:17186497 HAUS8;MYO9B 0.52 6.84 0.39 5.33e-11 Selective IgA deficiency; CESC cis rs2072499 0.966 rs1060604 chr1:156184268 T/C cg25208724 chr1:156163844 SLC25A44 0.95 15.46 0.69 7.1e-39 Testicular germ cell tumor; CESC cis rs11645898 1.000 rs72791115 chr16:72207315 T/C cg14768367 chr16:72042858 DHODH -0.64 -5.16 -0.3 4.75e-7 Blood protein levels; CESC cis rs10208940 0.777 rs6726966 chr2:68855856 A/G cg12452813 chr2:68675892 NA 0.49 5.04 0.3 8.69e-7 Urate levels in lean individuals; CESC cis rs7274811 0.711 rs373618 chr20:31992639 C/A cg21523528 chr20:32077966 CBFA2T2 -0.49 -5.66 -0.33 4.01e-8 Height; CESC cis rs7017914 0.934 rs13255886 chr8:71565954 G/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.4 -5.05 -0.3 8.32e-7 Bone mineral density; CESC cis rs7937682 0.883 rs12366001 chr11:111433916 A/G cg22437258 chr11:111473054 SIK2 -0.72 -8.72 -0.47 3.05e-16 Primary sclerosing cholangitis; CESC cis rs8017423 0.967 rs8021881 chr14:90722276 T/C cg14092571 chr14:90743983 NA -0.55 -8.31 -0.45 5.06e-15 Mortality in heart failure; CESC cis rs11167764 1.000 rs6887599 chr5:141484349 G/A cg08523384 chr5:141488047 NDFIP1 -0.37 -5.44 -0.32 1.2e-7 Crohn's disease; CESC cis rs2180341 0.814 rs9401959 chr6:127736464 T/C cg27446573 chr6:127587934 RNF146 0.83 12.03 0.59 6.99e-27 Breast cancer; CESC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg08888203 chr3:10149979 C3orf24 0.49 6.29 0.36 1.3e-9 Alzheimer's disease; CESC cis rs7107174 0.901 rs10899497 chr11:78124534 T/C cg02023728 chr11:77925099 USP35 0.43 5.61 0.33 5.1e-8 Testicular germ cell tumor; CESC trans rs6952407 1 rs6952407 chr7:66045512 A/G cg26939375 chr7:64535504 NA -0.68 -9.1 -0.49 2.18e-17 Cotinine glucuronidation; CESC cis rs2235642 0.821 rs8051895 chr16:1602811 A/G cg03771183 chr16:1608904 IFT140 0.4 5.9 0.34 1.12e-8 Coronary artery disease; CESC cis rs728616 0.558 rs72817596 chr10:82151594 T/C cg05935833 chr10:81318306 SFTPA2 -0.46 -5.79 -0.34 1.94e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs709400 0.633 rs10141433 chr14:103962559 A/G cg12935359 chr14:103987150 CKB -0.51 -7.44 -0.42 1.39e-12 Body mass index; CESC cis rs5753037 0.543 rs131268 chr22:30147938 C/G cg01021169 chr22:30184971 ASCC2 -0.55 -7.8 -0.43 1.39e-13 Type 1 diabetes; CESC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg10862848 chr6:42927986 GNMT -0.22 -5.53 -0.32 7.61e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs60843830 0.928 rs55742348 chr2:217563 T/A cg25945732 chr2:264204 ACP1;SH3YL1 0.87 11.47 0.58 5.47e-25 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs7144011 0.654 rs11159407 chr14:79868133 T/C cg24213196 chr17:40834836 CNTNAP1;CCR10 -0.46 -6.03 -0.35 5.47e-9 Waist circumference;Hip circumference; CESC cis rs1865721 0.804 rs72977816 chr18:73146779 A/T cg26385618 chr18:73139727 C18orf62 -0.52 -8.21 -0.45 1e-14 Intelligence; CESC cis rs7116495 0.867 rs4378421 chr11:71761996 T/C cg10381502 chr11:71823885 C11orf51 -1.16 -6.81 -0.39 6.4e-11 Severe influenza A (H1N1) infection; CESC cis rs2228479 0.850 rs45567439 chr16:89814604 G/A cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs7116495 0.609 rs7115513 chr11:71664495 T/A cg26138937 chr11:71823887 C11orf51 -1.21 -8.23 -0.45 8.31e-15 Severe influenza A (H1N1) infection; CESC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg27165867 chr14:105738592 BRF1 -0.48 -5.42 -0.32 1.32e-7 Mean platelet volume;Platelet distribution width; CESC cis rs6920965 0.602 rs10872302 chr6:126180631 G/T cg05901451 chr6:126070800 HEY2 -0.38 -5.23 -0.31 3.37e-7 High light scatter reticulocyte count; CESC cis rs13256369 0.802 rs12153 chr8:8560909 G/C cg18904891 chr8:8559673 CLDN23 0.71 7.96 0.44 4.92e-14 Obesity-related traits; CESC cis rs13191362 0.872 rs67712738 chr6:163245768 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.64 6.3 0.36 1.22e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg09323728 chr8:95962352 TP53INP1 -0.38 -8.23 -0.45 8.74e-15 Type 2 diabetes; CESC trans rs7107174 1.000 rs731600 chr11:77963133 A/G cg17250296 chr17:37331628 CACNB1 0.4 6.17 0.35 2.48e-9 Testicular germ cell tumor; CESC cis rs7618501 0.933 rs1128535 chr3:49866392 C/T cg24308560 chr3:49941425 MST1R -0.52 -6.97 -0.39 2.55e-11 Intelligence (multi-trait analysis); CESC cis rs6121246 0.697 rs45557936 chr20:30226690 G/A cg13852791 chr20:30311386 BCL2L1 0.77 7.87 0.44 9.26e-14 Mean corpuscular hemoglobin; CESC cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs8067545 0.586 rs11657161 chr17:20180715 A/G cg13482628 chr17:19912719 NA -0.42 -5.62 -0.33 4.92e-8 Schizophrenia; CESC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg11764359 chr7:65958608 NA -0.79 -11.58 -0.58 2.22e-25 Aortic root size; CESC cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg22875332 chr1:76189707 ACADM 0.71 9.93 0.52 5.79e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs295140 0.605 rs3739119 chr2:201194279 C/A cg23649088 chr2:200775458 C2orf69 -0.43 -5.64 -0.33 4.41e-8 QT interval; CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg10150615 chr22:24372951 LOC391322 -0.56 -7.39 -0.41 1.88e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1577917 0.917 rs12202170 chr6:86590386 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.23 -0.36 1.83e-9 Response to antipsychotic treatment; CESC cis rs2463822 0.844 rs2513737 chr11:62119495 G/C cg06239285 chr11:62104954 ASRGL1 0.86 8.63 0.47 5.79e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs709400 0.633 rs1951391 chr14:103898313 T/C cg12935359 chr14:103987150 CKB -0.48 -6.9 -0.39 3.71e-11 Body mass index; CESC cis rs7308134 0.766 rs73038195 chr12:2024092 T/C cg19708984 chr12:1973340 CACNA2D4 0.58 5.14 0.3 5.36e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg22920501 chr2:26401640 FAM59B -0.79 -9.3 -0.5 5.61e-18 Gut microbiome composition (summer); CESC cis rs9443645 0.901 rs1567167 chr6:79553827 C/T cg05283184 chr6:79620031 NA -0.43 -6.8 -0.39 6.92e-11 Intelligence (multi-trait analysis); CESC cis rs9291683 0.618 rs13137343 chr4:10043028 C/A cg11266682 chr4:10021025 SLC2A9 0.67 13.02 0.62 2.72e-30 Bone mineral density; CESC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.85 8.83 0.48 1.5e-16 Platelet count; CESC cis rs9611565 0.512 rs9611672 chr22:42209922 A/G cg06634786 chr22:41940651 POLR3H -0.65 -6.3 -0.36 1.21e-9 Vitiligo; CESC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg02592271 chr2:27665507 KRTCAP3 -0.3 -6.11 -0.35 3.62e-9 Total body bone mineral density; CESC cis rs8020095 0.571 rs10131614 chr14:67363542 A/C cg19548862 chr14:67692701 FAM71D -0.49 -6.03 -0.35 5.41e-9 Depression (quantitative trait); CESC cis rs8180040 1.000 rs1638676 chr3:47327651 A/G cg27129171 chr3:47204927 SETD2 0.66 10.09 0.53 1.82e-20 Colorectal cancer; CESC cis rs3091242 0.904 rs6661533 chr1:25771715 A/G cg27572855 chr1:25598939 RHD 0.49 8.4 0.46 2.82e-15 Erythrocyte sedimentation rate; CESC trans rs62103177 0.713 rs62103186 chr18:77627574 G/C cg05926928 chr17:57297772 GDPD1 1.18 10.14 0.53 1.27e-20 Opioid sensitivity; CESC cis rs9486719 0.948 rs11153059 chr6:97014537 T/A cg18709589 chr6:96969512 KIAA0776 -0.52 -5.69 -0.33 3.43e-8 Migraine;Coronary artery disease; CESC cis rs7264396 0.790 rs6060518 chr20:34217309 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.72 0.43 2.36e-13 Total cholesterol levels; CESC trans rs6570726 0.791 rs414297 chr6:145887556 C/T cg03826317 chr10:25465503 LOC100128811;GPR158 0.31 6.15 0.35 2.82e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.7 -8.63 -0.47 5.64e-16 Multiple sclerosis; CESC cis rs25645 0.502 rs7209742 chr17:38108708 A/G cg17467752 chr17:38218738 THRA 0.41 5.11 0.3 6.17e-7 Myeloid white cell count; CESC cis rs2882667 0.931 rs10044736 chr5:138320809 A/G cg04439458 chr5:138467593 SIL1 0.29 5.14 0.3 5.24e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs901683 1.000 rs35902429 chr10:46024335 T/C cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg12927641 chr6:109611667 NA 0.45 6.77 0.38 8.18e-11 Reticulocyte fraction of red cells; CESC cis rs60843830 0.964 rs17713568 chr2:242132 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.89 12.2 0.6 1.83e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs16893526 1.000 rs13214556 chr6:82496789 A/G cg22476893 chr17:7210162 EIF5A 0.78 6.06 0.35 4.53e-9 Coronary heart disease; CESC trans rs61931739 0.517 rs2636074 chr12:34064056 C/T cg26384229 chr12:38710491 ALG10B 0.52 6.96 0.39 2.64e-11 Morning vs. evening chronotype; CESC cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg13877915 chr19:58951672 ZNF132 0.39 5.79 0.34 1.99e-8 Uric acid clearance; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg03947735 chr13:111090467 COL4A2 0.48 6.0 0.35 6.38e-9 Subjective well-being; CESC cis rs2370759 1.000 rs2769241 chr10:32556229 T/C cg01819863 chr10:32635814 EPC1 -1.17 -12.03 -0.59 6.79e-27 Sexual dysfunction (female); CESC cis rs30380 0.632 rs149189 chr5:96137804 A/G cg16492584 chr5:96139282 ERAP1 -0.48 -6.78 -0.38 7.83e-11 Cerebrospinal fluid biomarker levels; CESC cis rs710216 0.917 rs900837 chr1:43412793 A/G cg07803811 chr1:43423981 SLC2A1 -0.5 -5.47 -0.32 1.02e-7 Red cell distribution width; CESC cis rs7683537 0.887 rs4540092 chr4:185633546 A/G cg04058563 chr4:185651563 MLF1IP 0.63 6.89 0.39 3.95e-11 Systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12343791 chr22:39240109 NPTXR -0.48 -6.37 -0.36 8.25e-10 Fibrinogen levels; CESC trans rs61931739 0.500 rs11052966 chr12:34019826 C/T cg26384229 chr12:38710491 ALG10B 0.47 6.49 0.37 4.23e-10 Morning vs. evening chronotype; CESC cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.58 -9.06 -0.49 2.92e-17 Breast cancer; CESC cis rs9902453 0.845 rs2628165 chr17:28121166 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 8.11 0.45 1.93e-14 Coffee consumption (cups per day); CESC cis rs10129255 0.917 rs8022493 chr14:107190057 C/T cg23076370 chr14:107095027 NA -0.46 -5.95 -0.34 8.57e-9 Kawasaki disease; CESC cis rs6763768 0.705 rs312483 chr3:53524051 A/G cg07507251 chr3:52567010 NT5DC2 -0.33 -5.03 -0.3 9.22e-7 Bacterial meningitis; CESC cis rs75477785 1.000 rs11119347 chr1:209983916 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs10089 1.000 rs6595806 chr5:127499764 A/T cg19767477 chr5:127420684 SLC12A2 -0.38 -5.15 -0.3 5.16e-7 Ileal carcinoids; CESC cis rs6754311 0.773 rs680428 chr2:136630757 A/G cg07169764 chr2:136633963 MCM6 -0.7 -8.51 -0.46 1.28e-15 Mosquito bite size; CESC cis rs2180341 0.883 rs6904630 chr6:127696869 A/G cg24812749 chr6:127587940 RNF146 1.05 14.95 0.68 4.44e-37 Breast cancer; CESC cis rs6456156 0.603 rs2345754 chr6:167484361 T/C cg07741184 chr6:167504864 NA 0.37 6.36 0.36 8.83e-10 Primary biliary cholangitis; CESC cis rs703842 0.616 rs4760171 chr12:58225904 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.55 6.74 0.38 1e-10 Multiple sclerosis; CESC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg23758822 chr17:41437982 NA 1.04 16.01 0.7 7.99e-41 Menopause (age at onset); CESC cis rs14403 0.519 rs3006917 chr1:243641971 C/T cg21452805 chr1:244014465 NA 0.55 5.86 0.34 1.37e-8 Schizophrenia; CESC cis rs17023223 0.537 rs12085616 chr1:119689148 A/C cg05756136 chr1:119680316 WARS2 -0.46 -5.58 -0.32 6.01e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs3733585 0.631 rs4697707 chr4:10119787 G/T cg00071950 chr4:10020882 SLC2A9 -0.62 -9.92 -0.52 6.42e-20 Cleft plate (environmental tobacco smoke interaction); CESC cis rs61931739 0.534 rs10844800 chr12:34230734 A/G cg19457237 chr12:34500585 NA -0.38 -5.29 -0.31 2.52e-7 Morning vs. evening chronotype; CESC cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg17376030 chr22:41985996 PMM1 -0.77 -8.31 -0.45 5.13e-15 Crohn's disease;Inflammatory bowel disease; CESC cis rs965469 0.696 rs6037570 chr20:3334292 C/A cg25506879 chr20:3388711 C20orf194 -0.48 -5.15 -0.3 5.18e-7 IFN-related cytopenia; CESC trans rs875971 0.737 rs7803424 chr7:65880605 T/C cg26939375 chr7:64535504 NA 0.47 6.14 0.35 3.07e-9 Aortic root size; CESC cis rs17095355 1.000 rs731793 chr10:111716667 C/G cg00817464 chr10:111662876 XPNPEP1 0.46 5.4 0.31 1.47e-7 Biliary atresia; CESC cis rs9487051 0.714 rs7774377 chr6:109602443 G/A cg12927641 chr6:109611667 NA -0.38 -5.66 -0.33 3.98e-8 Reticulocyte fraction of red cells; CESC cis rs4523957 0.820 rs2209073 chr17:2205664 G/A cg16513277 chr17:2031491 SMG6 0.59 7.77 0.43 1.78e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs796364 0.951 rs7565005 chr2:201013277 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -6.2 -0.36 2.13e-9 Schizophrenia; CESC cis rs7116495 0.609 rs10751191 chr11:71680920 C/T cg07596299 chr11:71824057 C11orf51 -0.83 -5.36 -0.31 1.8e-7 Severe influenza A (H1N1) infection; CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg24739457 chr1:205821442 NA 0.42 5.42 0.32 1.35e-7 Menarche (age at onset); CESC cis rs9302635 0.513 rs8061282 chr16:72155938 C/T cg16558253 chr16:72132732 DHX38 -0.46 -6.04 -0.35 5.09e-9 Blood protein levels; CESC cis rs9929218 0.551 rs9888942 chr16:68727572 A/G cg02972257 chr16:68554789 NA -0.44 -5.45 -0.32 1.15e-7 Colorectal cancer; CESC cis rs9296736 0.890 rs9370258 chr6:53910988 T/G cg04374786 chr6:53939321 C6orf142 0.34 5.3 0.31 2.46e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs8018808 0.935 rs2364156 chr14:77916746 G/A cg20045696 chr14:77926864 AHSA1 0.42 5.79 0.33 2.04e-8 Myeloid white cell count; CESC cis rs9768139 0.935 rs10155946 chr7:158122116 C/T cg06219351 chr7:158114137 PTPRN2 0.44 6.82 0.39 5.99e-11 Calcium levels; CESC trans rs7980799 0.935 rs10732554 chr12:33533374 C/T cg26384229 chr12:38710491 ALG10B -0.47 -6.3 -0.36 1.26e-9 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs597539 0.727 rs632984 chr11:68620271 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 9.33 0.5 4.51e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg03709012 chr19:19516395 GATAD2A 0.96 14.17 0.66 2.59e-34 Tonsillectomy; CESC cis rs12586317 0.511 rs113770696 chr14:35444383 C/T cg05294307 chr14:35346193 BAZ1A -0.49 -5.37 -0.31 1.75e-7 Psoriasis; CESC cis rs10465746 0.967 rs12732697 chr1:84349283 A/G cg10977910 chr1:84465055 TTLL7 0.48 6.52 0.37 3.63e-10 Obesity-related traits; CESC cis rs7635838 0.684 rs2606757 chr3:11358163 T/A cg00170343 chr3:11313890 ATG7 0.54 7.83 0.43 1.15e-13 HDL cholesterol; CESC cis rs938554 0.784 rs16868246 chr4:9978305 C/G cg00071950 chr4:10020882 SLC2A9 0.47 5.68 0.33 3.54e-8 Blood metabolite levels; CESC cis rs7191439 0.589 rs11076699 chr16:88756812 A/C cg27087555 chr16:88793112 FAM38A 0.72 5.17 0.3 4.68e-7 Plateletcrit; CESC cis rs8060686 0.623 rs56303487 chr16:68029739 C/T cg26727032 chr16:67993705 SLC12A4 -0.59 -8.03 -0.44 3.27e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs7086627 0.515 rs10887894 chr10:82209952 A/G cg03267442 chr10:82210566 NA -0.34 -5.6 -0.33 5.45e-8 Post bronchodilator FEV1; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg02739744 chr7:2613265 IQCE 0.5 6.76 0.38 8.66e-11 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs73206853 0.841 rs55972509 chr12:110992755 T/C cg12870014 chr12:110450643 ANKRD13A 0.63 5.29 0.31 2.51e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs6951245 0.554 rs79367977 chr7:1152657 G/A cg13565492 chr6:43139072 SRF -0.74 -8.88 -0.48 1.02e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7264396 0.635 rs6121102 chr20:34544274 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -11.49 -0.58 4.75e-25 Total cholesterol levels; CESC cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg12386194 chr3:101231763 SENP7 0.45 5.53 0.32 7.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs8005677 1.000 rs7145494 chr14:23399790 T/C cg01529538 chr14:23388837 RBM23 0.51 6.84 0.39 5.51e-11 Cognitive ability (multi-trait analysis); CESC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg27170947 chr2:26402098 FAM59B -0.59 -7.07 -0.4 1.36e-11 Gut microbiome composition (summer); CESC cis rs2230307 0.536 rs560659 chr1:100523536 A/G cg24955406 chr1:100503596 HIAT1 -0.57 -5.7 -0.33 3.21e-8 Carotid intima media thickness; CESC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg00750074 chr16:89608354 SPG7 -0.43 -6.22 -0.36 1.91e-9 Multiple myeloma (IgH translocation); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12072290 chr12:124018993 RILPL1 0.42 6.03 0.35 5.41e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs112790992 1 rs112790992 chr14:105758217 A/C cg13114125 chr14:105738426 BRF1 -0.71 -9.25 -0.49 7.96e-18 Platelet count; CESC cis rs1707322 1.000 rs4298677 chr1:46306619 G/A cg03146154 chr1:46216737 IPP 0.74 10.1 0.53 1.7e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1065852 0.526 rs9611711 chr22:42410695 G/A cg22189786 chr22:42395067 WBP2NL 0.41 5.22 0.31 3.55e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs748404 0.560 rs572837 chr15:43823813 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.55 7.09 0.4 1.2e-11 Lung cancer; CESC cis rs7178909 0.933 rs7183156 chr15:90445446 A/G cg19708238 chr15:90437601 AP3S2 0.43 5.89 0.34 1.19e-8 Common traits (Other); CESC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg05234568 chr11:5960015 NA -0.66 -9.65 -0.51 4.4e-19 DNA methylation (variation); CESC cis rs660498 0.507 rs34467586 chr10:27742027 C/T cg25705717 chr10:27608719 NA 0.46 5.72 0.33 2.83e-8 Asthma (childhood onset); CESC cis rs34779708 0.931 rs2001893 chr10:35300623 G/A cg04310649 chr10:35416472 CREM -0.51 -6.14 -0.35 2.92e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs8077577 0.945 rs11654146 chr17:18076141 A/C cg16794390 chr17:18148240 FLII 0.42 5.64 0.33 4.41e-8 Obesity-related traits; CESC cis rs7914558 0.966 rs7908280 chr10:104816947 C/G cg15744005 chr10:104629667 AS3MT -0.34 -5.5 -0.32 8.8e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs727563 0.520 rs132773 chr22:42031768 T/A cg03806693 chr22:41940476 POLR3H 1.05 12.5 0.61 1.69e-28 Crohn's disease;Inflammatory bowel disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01187952 chr3:63850081 THOC7;ATXN7 -0.38 -6.03 -0.35 5.38e-9 Gambling; CESC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg19346786 chr7:2764209 NA -0.51 -7.45 -0.42 1.35e-12 Height; CESC cis rs7959452 0.535 rs2305641 chr12:69646914 C/T cg20891283 chr12:69753455 YEATS4 0.76 11.37 0.57 1.2e-24 Blood protein levels; CESC cis rs9596863 0.950 rs7334923 chr13:54394765 G/T ch.13.53330881F chr13:54432880 NA 0.66 5.36 0.31 1.84e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs2050392 0.517 rs2480299 chr10:30743197 G/A cg18806716 chr10:30721971 MAP3K8 -0.5 -7.68 -0.43 3.1400000000000003e-13 Inflammatory bowel disease; CESC cis rs2180341 0.843 rs4895821 chr6:127572761 T/A cg24812749 chr6:127587940 RNF146 1.08 15.45 0.69 7.93e-39 Breast cancer; CESC cis rs9487051 0.676 rs6925716 chr6:109597641 T/C cg12927641 chr6:109611667 NA -0.37 -5.51 -0.32 8.49e-8 Reticulocyte fraction of red cells; CESC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg00166722 chr3:10149974 C3orf24 0.45 5.65 0.33 4.12e-8 Alzheimer's disease; CESC cis rs7949030 0.588 rs2428548 chr11:62311462 A/G cg02375832 chr11:62437615 C11orf48 -0.36 -5.34 -0.31 1.98e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1878931 0.624 rs28089 chr16:3446937 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.79 -8.98 -0.48 5.1e-17 Body mass index (adult); CESC trans rs11148252 0.595 rs4885325 chr13:53171317 C/T cg18335740 chr13:41363409 SLC25A15 0.56 7.72 0.43 2.32e-13 Lewy body disease; CESC cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg11812906 chr14:75593930 NEK9 -0.88 -14.15 -0.66 3.18e-34 Height; CESC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg08499158 chr17:42289980 UBTF -0.52 -6.53 -0.37 3.27e-10 Total body bone mineral density; CESC cis rs295140 0.507 rs1369842 chr2:201108987 C/A cg23649088 chr2:200775458 C2orf69 -0.42 -5.76 -0.33 2.35e-8 QT interval; CESC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg04944784 chr2:26401820 FAM59B 0.96 10.83 0.55 7.34e-23 Gut microbiome composition (summer); CESC cis rs36051895 0.664 rs28378223 chr9:5113087 C/G cg02405213 chr9:5042618 JAK2 -0.47 -5.88 -0.34 1.26e-8 Pediatric autoimmune diseases; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07257649 chr6:4776641 CDYL 0.61 7.09 0.4 1.2e-11 Gut microbiome composition (summer); CESC cis rs4835473 0.932 rs1849128 chr4:144913735 C/T cg25736465 chr4:144833511 NA 0.43 6.44 0.37 5.61e-10 Immature fraction of reticulocytes; CESC cis rs57506017 0.585 rs7804234 chr7:12266814 A/G cg23422036 chr7:12250390 TMEM106B 0.38 5.17 0.3 4.7e-7 Neuroticism; CESC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg18337363 chr3:52569053 NT5DC2 0.29 5.11 0.3 6.24e-7 Bipolar disorder; CESC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg09359103 chr1:154839909 KCNN3 -0.65 -12.33 -0.6 6.58e-28 Prostate cancer; CESC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg09699651 chr6:150184138 LRP11 0.39 5.04 0.3 8.83e-7 Lung cancer; CESC cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs921968 0.643 rs500317 chr2:219432953 G/C cg02176678 chr2:219576539 TTLL4 0.41 7.13 0.4 9.62e-12 Mean corpuscular hemoglobin concentration; CESC cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg00409905 chr10:38381863 ZNF37A -0.45 -5.96 -0.34 7.89e-9 Extrinsic epigenetic age acceleration; CESC cis rs11098499 0.954 rs3733520 chr4:120423480 C/G cg24375607 chr4:120327624 NA 0.46 5.75 0.33 2.42e-8 Corneal astigmatism; CESC cis rs2456568 0.548 rs6483281 chr11:93661840 G/C cg26875233 chr11:93583750 C11orf90 -0.33 -5.84 -0.34 1.52e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02576381 chr5:159827164 C5orf54 0.45 6.25 0.36 1.59e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg21951975 chr1:209979733 IRF6 0.44 7.62 0.42 4.58e-13 Monobrow; CESC cis rs9309473 0.948 rs7607892 chr2:73818707 C/T cg20560298 chr2:73613845 ALMS1 -0.53 -7.03 -0.4 1.75e-11 Metabolite levels; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg05673432 chr3:15919505 NA -0.54 -6.8 -0.39 7.11e-11 Breast cancer;Type 2 diabetes; CESC trans rs1814175 0.817 rs2866863 chr11:49953242 C/T cg03929089 chr4:120376271 NA -0.93 -15.75 -0.7 6.66e-40 Height; CESC cis rs8005677 0.798 rs4536383 chr14:23410926 T/C cg01529538 chr14:23388837 RBM23 0.44 5.83 0.34 1.63e-8 Cognitive ability (multi-trait analysis); CESC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.21 -0.53 7.17e-21 Alzheimer's disease; CESC cis rs11864453 0.713 rs3764312 chr16:72125733 A/C cg16558253 chr16:72132732 DHX38 -0.56 -8.7 -0.47 3.62e-16 Fibrinogen levels; CESC cis rs7524258 0.868 rs2412153 chr1:7272412 C/T cg07173049 chr1:7289937 CAMTA1 0.37 5.5 0.32 8.98e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg03188948 chr7:1209495 NA 0.47 6.1 0.35 3.7e-9 Longevity;Endometriosis; CESC cis rs4455778 0.536 rs887451 chr7:48943352 T/C cg26309511 chr7:48887640 NA -0.35 -5.11 -0.3 6.1e-7 Lung cancer in never smokers; CESC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg09365446 chr1:150670422 GOLPH3L 0.41 5.77 0.33 2.22e-8 Tonsillectomy; CESC trans rs17764205 0.777 rs17696630 chr19:3261995 A/G cg04564646 chr1:113217655 MOV10 -0.8 -6.28 -0.36 1.4e-9 Bipolar disorder and schizophrenia; CESC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg02353165 chr6:42928485 GNMT -0.83 -13.77 -0.65 6.71e-33 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4362 0.934 rs4343 chr17:61566031 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.4 5.39 0.31 1.6e-7 Blood metabolite levels; CESC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg00684032 chr4:1343700 KIAA1530 0.4 5.73 0.33 2.76e-8 Obesity-related traits; CESC cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg09658497 chr7:2847517 GNA12 -0.44 -6.86 -0.39 4.8e-11 Height; CESC cis rs1957429 0.808 rs7144718 chr14:65333831 G/A cg23373153 chr14:65346875 NA 0.89 9.19 0.49 1.19e-17 Pediatric areal bone mineral density (radius); CESC cis rs7678296 0.649 rs73128366 chr4:37241908 T/C cg06805348 chr4:37245195 KIAA1239 0.53 5.79 0.33 2.04e-8 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs12995849 0.714 rs6543342 chr2:106462256 T/C cg16077055 chr2:106428750 NCK2 0.39 5.81 0.34 1.75e-8 Addiction; CESC cis rs7582720 1.000 rs7582720 chr2:203753072 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs17673138 0.631 rs17673099 chr8:32696905 A/C cg05233373 chr2:161127261 NA 0.54 6.15 0.35 2.86e-9 Pharmacokinetics of olanzapine in severe mental disorder (concentration dose ratio); CESC cis rs12079745 0.793 rs12061405 chr1:169208368 G/A cg09363564 chr1:169337483 NME7;BLZF1 -1.13 -6.57 -0.37 2.58e-10 QT interval; CESC trans rs1814175 0.645 rs11040702 chr11:50024827 C/T cg03929089 chr4:120376271 NA -0.91 -14.8 -0.67 1.58e-36 Height; CESC cis rs4604732 0.588 rs4925551 chr1:247631724 T/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 5.96 0.34 7.9e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7523050 0.643 rs67567504 chr1:109402580 C/A cg08274380 chr1:109419600 GPSM2 0.86 5.69 0.33 3.36e-8 Fat distribution (HIV); CESC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg08888203 chr3:10149979 C3orf24 0.53 6.72 0.38 1.11e-10 Alzheimer's disease; CESC cis rs4319547 0.656 rs10744209 chr12:122931568 G/A cg05707623 chr12:122985044 ZCCHC8 -0.5 -5.77 -0.33 2.19e-8 Body mass index; CESC cis rs34779708 0.931 rs4934700 chr10:35310842 A/G cg03585969 chr10:35415529 CREM 0.76 10.03 0.52 2.79e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs10927875 0.722 rs1763605 chr1:16338925 T/G cg21385522 chr1:16154831 NA 0.62 7.51 0.42 9.21e-13 Dilated cardiomyopathy; CESC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg05234568 chr11:5960015 NA -0.65 -9.12 -0.49 1.91e-17 DNA methylation (variation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25867694 chr22:31503597 SELM 0.59 6.52 0.37 3.45e-10 Gut microbiome composition (summer); CESC cis rs4642101 0.618 rs11128614 chr3:12819212 A/G cg05775895 chr3:12838266 CAND2 0.36 5.35 0.31 1.93e-7 QRS complex (12-leadsum); CESC cis rs12477438 0.520 rs11695379 chr2:99742161 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.67 0.69 1.26e-39 Chronic sinus infection; CESC cis rs2070488 0.965 rs13079145 chr3:38517992 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.95 17.58 0.73 2.16e-46 Electrocardiographic conduction measures; CESC cis rs9486719 1.000 rs4077932 chr6:96905144 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.45e-15 Migraine;Coronary artery disease; CESC cis rs1062177 1.000 rs2915878 chr5:151149662 A/G cg00977110 chr5:151150581 G3BP1 0.66 7.09 0.4 1.25e-11 Preschool internalizing problems; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12357364 chr17:1557144 PRPF8 -0.55 -6.33 -0.36 1.02e-9 Gut microbiome composition (summer); CESC cis rs12291225 0.679 rs11369 chr11:14288096 A/G cg19336497 chr11:14380999 RRAS2 -0.37 -5.37 -0.31 1.72e-7 Sense of smell; CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg17949981 chr6:28129498 ZNF389 0.47 5.86 0.34 1.37e-8 Depression; CESC cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg05340658 chr4:99064831 C4orf37 0.78 11.87 0.59 2.5e-26 Colonoscopy-negative controls vs population controls; CESC cis rs9948 0.529 rs62156222 chr2:97410988 C/A cg01990225 chr2:97406019 LMAN2L -0.98 -7.35 -0.41 2.39e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs7772486 0.875 rs1960885 chr6:146325930 G/T cg23711669 chr6:146136114 FBXO30 0.79 11.12 0.56 7.65e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs10220309 0.501 rs2216086 chr14:80642320 C/T cg08183125 chr14:80678293 DIO2 -0.43 -5.51 -0.32 8.66e-8 Lung function (FEV1); CESC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg16606324 chr3:10149918 C3orf24 0.42 5.27 0.31 2.8e-7 Alzheimer's disease; CESC cis rs12579753 0.879 rs11115007 chr12:82164673 A/T cg23701643 chr12:82153290 PPFIA2 -0.36 -5.26 -0.31 2.92e-7 Resting heart rate; CESC cis rs72781680 0.560 rs111310684 chr2:24265682 C/G cg06627628 chr2:24431161 ITSN2 -0.65 -6.21 -0.36 2.08e-9 Lymphocyte counts; CESC cis rs4474465 0.736 rs10899550 chr11:78256078 G/A cg27205649 chr11:78285834 NARS2 0.42 5.32 0.31 2.16e-7 Alzheimer's disease (survival time); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05237023 chr16:75182837 ZFP1 0.56 7.22 0.41 5.41e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs12893668 0.703 rs34026011 chr14:104050883 G/A cg24130564 chr14:104152367 KLC1 -0.46 -5.75 -0.33 2.47e-8 Reticulocyte count; CESC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg18357526 chr6:26021779 HIST1H4A 0.77 10.74 0.55 1.47e-22 Intelligence (multi-trait analysis); CESC cis rs3845702 0.736 rs3843323 chr2:180856459 T/C cg01881094 chr2:180872142 CWC22 -1.08 -10.12 -0.53 1.5e-20 Schizophrenia; CESC cis rs17854409 0.764 rs12625513 chr20:61475661 G/A cg05147244 chr20:61493195 TCFL5 1.09 5.94 0.34 9.12e-9 Obesity-related traits; CESC cis rs17666538 0.710 rs12716640 chr8:645376 A/C cg07685180 chr8:600429 NA 0.59 5.2 0.3 3.9e-7 IgG glycosylation; CESC cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg06627628 chr2:24431161 ITSN2 -0.67 -6.45 -0.37 5.4e-10 Lymphocyte counts; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01727434 chr2:152118530 RBM43 0.49 6.35 0.36 9.54e-10 Gut microbiota (bacterial taxa); CESC cis rs11711311 1.000 rs9826465 chr3:113432254 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.58 7.73 0.43 2.27e-13 IgG glycosylation; CESC cis rs1801251 1.000 rs2012221 chr2:233566848 T/C cg08000102 chr2:233561755 GIGYF2 0.66 9.02 0.48 3.78e-17 Coronary artery disease; CESC cis rs28551159 1 rs28551159 chr6:26376368 A/G cg14345882 chr6:26364793 BTN3A2 0.61 6.18 0.35 2.4e-9 Urinary tract infection frequency; CESC cis rs7666738 0.830 rs17548431 chr4:98923768 C/G cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs72634258 0.554 rs4908705 chr1:7926401 C/T cg00042356 chr1:8021962 PARK7 0.47 5.22 0.31 3.69e-7 Inflammatory bowel disease; CESC cis rs9584850 0.915 rs7983438 chr13:99103317 T/C cg22223119 chr13:99095684 FARP1 -0.37 -5.32 -0.31 2.16e-7 Neuroticism; CESC cis rs3135063 0.847 rs1138690 chr4:3291401 G/T cg00060484 chr4:3287598 NA -0.33 -5.19 -0.3 4.12e-7 Blood protein levels; CESC cis rs926938 0.505 rs2878573 chr1:115521602 A/G cg12756093 chr1:115239321 AMPD1 0.45 6.15 0.35 2.84e-9 Autism; CESC cis rs6076065 0.722 rs6048760 chr20:23345844 G/T cg11657817 chr20:23433608 CST11 -0.38 -5.71 -0.33 2.96e-8 Facial morphology (factor 15, philtrum width); CESC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg08888203 chr3:10149979 C3orf24 0.44 5.71 0.33 3.09e-8 Alzheimer's disease; CESC cis rs2243480 0.831 rs57294491 chr7:65684901 T/A cg12463550 chr7:65579703 CRCP -0.73 -5.67 -0.33 3.81e-8 Diabetic kidney disease; CESC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg11644478 chr21:40555479 PSMG1 1.01 16.75 0.72 1.91e-43 Cognitive function; CESC cis rs6570726 0.791 rs422099 chr6:145806936 C/T cg23711669 chr6:146136114 FBXO30 1.0 15.78 0.7 5.42e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs868036 0.609 rs2278076 chr15:68099600 C/T cg08079166 chr15:68083412 MAP2K5 0.41 5.66 0.33 3.85e-8 Restless legs syndrome; CESC cis rs7412746 0.658 rs4970988 chr1:150950062 A/G cg04414720 chr1:150670196 GOLPH3L -0.46 -6.0 -0.35 6.29e-9 Melanoma; CESC cis rs66530629 0.834 rs11249171 chr1:25073571 A/C cg22509179 chr1:25234806 RUNX3 -0.48 -6.26 -0.36 1.56e-9 Plateletcrit; CESC cis rs9768139 0.627 rs57920447 chr7:158121243 A/G cg06219351 chr7:158114137 PTPRN2 -0.49 -7.53 -0.42 7.74e-13 Calcium levels; CESC cis rs17376456 0.542 rs1982439 chr5:93160560 C/G cg25358565 chr5:93447407 FAM172A -0.7 -7.35 -0.41 2.52e-12 Diabetic retinopathy; CESC cis rs533581 0.708 rs2968475 chr16:88976663 C/G cg16701003 chr16:89028210 CBFA2T3 0.54 7.54 0.42 7.5e-13 Social autistic-like traits; CESC cis rs1832871 0.711 rs12525147 chr6:158683509 A/G cg07165851 chr6:158734300 TULP4 0.55 5.41 0.32 1.41e-7 Height; CESC cis rs11958404 0.932 rs76601259 chr5:157430337 C/T cg05962755 chr5:157440814 NA 0.63 6.63 0.38 1.87e-10 IgG glycosylation; CESC cis rs75804782 0.641 rs72985387 chr2:239336589 G/A cg18131467 chr2:239335373 ASB1 -0.67 -5.74 -0.33 2.54e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs7914558 0.966 rs1890185 chr10:104748718 A/G cg08650961 chr10:104748594 CNNM2 0.33 5.35 0.31 1.92e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs854765 0.654 rs9911281 chr17:17762457 G/C cg04398451 chr17:18023971 MYO15A 0.67 10.08 0.53 1.98e-20 Total body bone mineral density; CESC cis rs12618769 0.597 rs3769725 chr2:99105967 A/G cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs193541 0.632 rs34486978 chr5:122312543 G/A cg19412675 chr5:122181750 SNX24 -0.46 -5.44 -0.32 1.22e-7 Glucose homeostasis traits; CESC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs9527 0.590 rs10883834 chr10:104881402 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg22920501 chr2:26401640 FAM59B -0.69 -8.44 -0.46 2.06e-15 Gut microbiome composition (summer); CESC cis rs1559088 1.000 rs28803235 chr19:33561804 G/A cg27124370 chr19:33622961 WDR88 0.41 5.04 0.3 8.46e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7659604 0.540 rs4455438 chr4:122669550 G/A cg19671926 chr4:122722719 EXOSC9 0.53 6.55 0.37 3e-10 Type 2 diabetes; CESC cis rs35110281 0.641 rs9983670 chr21:45083425 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -8.9 -0.48 9.29e-17 Mean corpuscular volume; CESC cis rs7107174 1.000 rs7119933 chr11:78049750 A/C cg02023728 chr11:77925099 USP35 0.39 5.54 0.32 7.12e-8 Testicular germ cell tumor; CESC cis rs7617773 0.925 rs34513961 chr3:48173653 T/C cg20734569 chr3:48348370 SPINK8 -0.37 -5.05 -0.3 8.23e-7 Coronary artery disease; CESC cis rs2929278 0.561 rs62018952 chr15:44080737 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.47 -7.35 -0.41 2.48e-12 Schizophrenia; CESC cis rs1008375 0.797 rs6843530 chr4:17593605 G/T cg02297831 chr4:17616191 MED28 0.5 6.23 0.36 1.81e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7116495 1.000 rs4945435 chr11:71759219 C/T cg10381502 chr11:71823885 C11orf51 -0.65 -5.48 -0.32 9.66e-8 Severe influenza A (H1N1) infection; CESC cis rs12142240 0.698 rs7515598 chr1:46818479 C/T cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs1355223 1.000 rs11602909 chr11:34768003 T/C cg11058730 chr11:34937778 PDHX;APIP -0.43 -5.62 -0.33 4.73e-8 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs863345 0.604 rs6689657 chr1:158462509 C/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.17 -0.4 7.29e-12 Pneumococcal bacteremia; CESC cis rs7264396 0.790 rs6060562 chr20:34282053 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.65 6.96 0.39 2.62e-11 Total cholesterol levels; CESC cis rs11098499 0.866 rs6857892 chr4:120282696 G/T cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs36051895 0.632 rs12684720 chr9:5150800 T/C cg02405213 chr9:5042618 JAK2 -0.52 -6.45 -0.37 5.42e-10 Pediatric autoimmune diseases; CESC cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg11812906 chr14:75593930 NEK9 -0.85 -13.94 -0.65 1.65e-33 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00298532 chr1:9790325 CLSTN1 0.47 6.38 0.36 8.03e-10 Fibrinogen levels; CESC cis rs6120849 0.754 rs36003887 chr20:33589107 G/A cg24642439 chr20:33292090 TP53INP2 0.67 6.62 0.38 1.94e-10 Protein C levels; CESC cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg23711669 chr6:146136114 FBXO30 0.84 11.1 0.56 9.14e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs9858542 0.953 rs9827708 chr3:49649989 C/G cg03060546 chr3:49711283 APEH -0.55 -6.65 -0.38 1.63e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2243480 1.000 rs10807701 chr7:65724686 C/A cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC trans rs12265790 1.000 rs11253672 chr10:15928339 T/C cg03460745 chr3:171966142 FNDC3B 0.75 6.02 0.35 5.81e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19091447 chr20:37555378 FAM83D -0.47 -6.68 -0.38 1.37e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6500602 0.627 rs11639998 chr16:4527109 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.42 5.84 0.34 1.56e-8 Schizophrenia; CESC cis rs9788682 0.747 rs2036533 chr15:78781687 G/A cg24631222 chr15:78858424 CHRNA5 0.64 7.65 0.43 3.69e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs11227306 0.902 rs625652 chr11:65641931 T/A cg04055107 chr11:65626734 MUS81;CFL1 -0.49 -5.45 -0.32 1.13e-7 DNA methylation (variation); CESC cis rs9457247 1.000 rs2757042 chr6:167371234 A/T cg25258033 chr6:167368657 RNASET2 -0.39 -5.98 -0.34 7.29e-9 Crohn's disease; CESC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.87 7.44 0.42 1.39e-12 Depression; CESC cis rs10751667 0.577 rs7946461 chr11:974035 A/G cg20946044 chr11:1010712 AP2A2 -0.39 -5.32 -0.31 2.24e-7 Alzheimer's disease (late onset); CESC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg12963246 chr6:28129442 ZNF389 0.4 5.82 0.34 1.65e-8 Cardiac Troponin-T levels; CESC cis rs9916302 0.904 rs4357971 chr17:37717280 C/T cg15445000 chr17:37608096 MED1 0.42 6.83 0.39 5.67e-11 Glomerular filtration rate (creatinine); CESC cis rs1847202 0.859 rs4550778 chr3:72949198 G/A cg25664220 chr3:72788482 NA -0.37 -5.44 -0.32 1.2e-7 Motion sickness; CESC cis rs8020095 0.571 rs8022657 chr14:67390499 C/T cg19548862 chr14:67692701 FAM71D -0.49 -6.01 -0.35 6.16e-9 Depression (quantitative trait); CESC cis rs6570726 0.935 rs366308 chr6:145814532 T/A cg23711669 chr6:146136114 FBXO30 0.82 12.29 0.6 8.74e-28 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07269724 chr19:12904655 NA -0.42 -6.14 -0.35 2.94e-9 Gambling; CESC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg17724175 chr1:150552817 MCL1 0.34 5.3 0.31 2.39e-7 Melanoma; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg23850377 chr2:20251576 LAPTM4A 0.52 6.99 0.39 2.29e-11 Systemic lupus erythematosus; CESC cis rs4727963 0.846 rs4574772 chr7:122701537 C/T cg03640110 chr7:122635026 TAS2R16 -0.37 -5.7 -0.33 3.11e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs6580649 0.941 rs4760677 chr12:48449163 C/T cg24011408 chr12:48396354 COL2A1 -0.42 -5.28 -0.31 2.67e-7 Lung cancer; CESC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg06600287 chr1:53387719 ECHDC2 -0.27 -5.05 -0.3 8.13e-7 Monocyte count; CESC cis rs9788682 0.747 rs2958719 chr15:78743029 G/A cg24631222 chr15:78858424 CHRNA5 -0.61 -7.19 -0.4 6.65e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg06688411 chr11:65153958 FRMD8 -0.46 -6.44 -0.37 5.59e-10 Vertical cup-disc ratio; CESC cis rs10857712 0.851 rs7913420 chr10:135213854 C/T cg01444801 chr10:135216882 MTG1 -0.47 -5.41 -0.32 1.38e-7 Systemic lupus erythematosus; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17322163 chr12:51632344 DAZAP2 0.46 6.06 0.35 4.75e-9 Gut microbiota (bacterial taxa); CESC cis rs2274273 0.870 rs10134339 chr14:55814380 T/C cg04306507 chr14:55594613 LGALS3 0.32 6.31 0.36 1.19e-9 Protein biomarker; CESC cis rs7044106 0.791 rs10984995 chr9:123479210 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.14 0.63 1.07e-30 Hip circumference adjusted for BMI; CESC trans rs9435732 1.000 rs9435732 chr1:17308158 C/T cg26354191 chr1:3547523 WDR8 -0.37 -6.22 -0.36 1.93e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in smokers;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC trans rs35110281 0.811 rs1122873 chr21:45044672 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 7.27 0.41 3.97e-12 Mean corpuscular volume; CESC cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg01448562 chr3:133502909 NA -0.58 -8.46 -0.46 1.86e-15 Iron status biomarkers; CESC cis rs6499255 0.857 rs11643926 chr16:69807282 A/G cg15192750 chr16:69999425 NA 0.45 5.59 0.32 5.59e-8 IgE levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06406294 chr21:34915161 GART;SON 0.59 7.05 0.4 1.59e-11 Gut microbiome composition (summer); CESC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg03452623 chr4:187889614 NA -0.94 -18.98 -0.76 2.61e-51 Lobe attachment (rater-scored or self-reported); CESC cis rs290268 1.000 rs188313 chr9:93548302 C/T cg02608019 chr9:93564028 SYK 0.64 9.38 0.5 3.11e-18 Platelet count; CESC cis rs68170813 0.559 rs1018946 chr7:106851754 T/C cg02696742 chr7:106810147 HBP1 -0.52 -5.09 -0.3 6.84e-7 Coronary artery disease; CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg23034840 chr1:205782522 SLC41A1 -0.72 -9.76 -0.51 1.94e-19 Monocyte percentage of white cells; CESC cis rs963731 0.649 rs4670272 chr2:39260468 A/C cg04010122 chr2:39346883 SOS1 -0.7 -5.11 -0.3 6.16e-7 Corticobasal degeneration; CESC cis rs7264396 0.563 rs2425130 chr20:34335059 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.72 0.38 1.08e-10 Total cholesterol levels; CESC cis rs11734570 0.581 rs55958238 chr4:38604331 A/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.63 7.75 0.43 1.94e-13 Inflammatory bowel disease;Crohn's disease; CESC cis rs911555 0.723 rs56227024 chr14:103861706 A/G cg24130564 chr14:104152367 KLC1 0.45 6.3 0.36 1.27e-9 Intelligence (multi-trait analysis); CESC cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg16240275 chr20:61666158 NCRNA00029 0.5 8.94 0.48 6.65e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs9399135 1.000 rs4896130 chr6:135355118 C/T cg22676075 chr6:135203613 NA 0.49 6.89 0.39 4.03e-11 Red blood cell count; CESC cis rs7771547 0.573 rs547026 chr6:36398616 G/A cg07856975 chr6:36356162 ETV7 0.36 5.42 0.32 1.37e-7 Platelet distribution width; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16672449 chr3:127842622 RUVBL1 0.52 6.94 0.39 2.95e-11 Gut microbiota (bacterial taxa); CESC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg04369109 chr6:150039330 LATS1 -0.46 -6.31 -0.36 1.2e-9 Lung cancer; CESC trans rs61931739 0.500 rs6488213 chr12:34393319 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.75 0.43 2.01e-13 Morning vs. evening chronotype; CESC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs8028182 0.636 rs11636031 chr15:75815758 T/C cg20655648 chr15:75932815 IMP3 0.48 5.9 0.34 1.08e-8 Sudden cardiac arrest; CESC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg18404041 chr3:52824283 ITIH1 -0.48 -8.0 -0.44 3.77e-14 Bipolar disorder; CESC cis rs4555082 0.874 rs78923231 chr14:105754033 C/T cg06808227 chr14:105710500 BRF1 -0.52 -5.62 -0.33 4.87e-8 Mean platelet volume;Platelet distribution width; CESC trans rs7937682 0.889 rs1789361 chr11:111485334 T/C cg18187862 chr3:45730750 SACM1L 0.48 6.04 0.35 5.23e-9 Primary sclerosing cholangitis; CESC cis rs4803468 0.934 rs11880674 chr19:41889423 A/T cg14132834 chr19:41945861 ATP5SL -0.55 -6.83 -0.39 5.87e-11 Height; CESC cis rs2531992 0.800 rs1045476 chr16:4015313 A/G cg05927578 chr16:4029543 ADCY9 0.46 6.1 0.35 3.72e-9 Waist circumference; CESC cis rs752010 0.574 rs12130138 chr1:42117792 A/C cg06885757 chr1:42089581 HIVEP3 0.48 7.61 0.42 4.72e-13 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03350042 chr15:40733177 BAHD1 0.56 6.41 0.37 6.45e-10 Gut microbiome composition (summer); CESC cis rs4927850 0.752 rs7618864 chr3:195749561 G/A cg00031303 chr3:195681400 NA 0.43 5.43 0.32 1.26e-7 Pancreatic cancer; CESC cis rs73206853 0.640 rs35026231 chr12:110832125 A/G cg12870014 chr12:110450643 ANKRD13A 0.63 5.23 0.31 3.48e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg05754148 chr16:3507555 NAT15 -0.56 -8.34 -0.46 4.02e-15 Tuberculosis; CESC cis rs7666738 0.830 rs35276471 chr4:99068691 A/T cg05340658 chr4:99064831 C4orf37 0.83 12.82 0.62 1.36e-29 Colonoscopy-negative controls vs population controls; CESC cis rs9818758 0.545 rs55921200 chr3:49189316 T/C cg00383909 chr3:49044727 WDR6 0.93 5.4 0.31 1.51e-7 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs1707322 0.648 rs4439382 chr1:46150805 C/T cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs59751489 chr4:98933802 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7762018 0.556 rs80250989 chr6:170105553 T/C cg19338460 chr6:170058176 WDR27 -1.04 -8.47 -0.46 1.75e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06786349 chr20:19815086 NA -0.37 -6.18 -0.35 2.38e-9 Gambling; CESC cis rs7762018 1.000 rs7746598 chr6:170084933 T/A cg05834625 chr6:170176447 C6orf70 0.62 7.41 0.41 1.7e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs12042938 0.600 rs1865225 chr1:231763004 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.4 -5.09 -0.3 6.85e-7 Neuranatomic and neurocognitive phenotypes; CESC cis rs8099014 0.861 rs2277722 chr18:56121280 G/C cg19312305 chr18:56117016 MIR122 -0.27 -5.4 -0.31 1.51e-7 Platelet count; CESC cis rs11785400 0.793 rs4336593 chr8:143739647 A/C cg10596483 chr8:143751796 JRK -0.44 -5.5 -0.32 8.81e-8 Schizophrenia; CESC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg22974920 chr21:40686053 BRWD1 -0.42 -5.21 -0.3 3.77e-7 Cognitive function; CESC cis rs9457247 0.602 rs2157388 chr6:167481912 G/A cg07741184 chr6:167504864 NA 0.39 6.89 0.39 4.08e-11 Crohn's disease; CESC cis rs9549367 0.713 rs9549682 chr13:113830181 C/T cg18105134 chr13:113819100 PROZ -0.7 -8.39 -0.46 2.95e-15 Platelet distribution width; CESC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg05368731 chr17:41323189 NBR1 0.79 10.96 0.56 2.64e-23 Menopause (age at onset); CESC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs992157 0.687 rs10206984 chr2:219066980 C/T cg00012203 chr2:219082015 ARPC2 0.86 12.41 0.61 3.6e-28 Colorectal cancer; CESC cis rs8014204 0.762 rs973879 chr14:75297727 T/C cg08847533 chr14:75593920 NEK9 0.43 5.6 0.33 5.27e-8 Caffeine consumption; CESC cis rs9640161 0.789 rs2098053 chr7:150043205 G/A cg27494647 chr7:150038898 RARRES2 0.44 5.24 0.31 3.36e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs2243480 1.000 rs1964692 chr7:65454183 G/A cg13147721 chr7:65941812 NA -0.89 -8.55 -0.47 9.65e-16 Diabetic kidney disease; CESC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg23221052 chr5:179740743 GFPT2 0.54 7.41 0.41 1.66e-12 Height; CESC cis rs12893668 0.543 rs12147645 chr14:104100208 T/A cg24130564 chr14:104152367 KLC1 -0.5 -6.51 -0.37 3.71e-10 Reticulocyte count; CESC cis rs6831352 0.918 rs7670638 chr4:100059807 G/C cg13256891 chr4:100009986 ADH5 -0.75 -8.21 -0.45 9.89e-15 Alcohol dependence; CESC cis rs6939532 0.648 rs9379862 chr6:26370707 T/C cg14345882 chr6:26364793 BTN3A2 0.38 5.64 0.33 4.36e-8 Autism spectrum disorder or schizophrenia; CESC cis rs1559088 0.847 rs7254758 chr19:33608047 T/A cg27124370 chr19:33622961 WDR88 0.42 5.55 0.32 7.06e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs12887734 0.524 rs4906363 chr14:104210239 G/A cg08213375 chr14:104286397 PPP1R13B 0.44 7.43 0.42 1.54e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs2456568 0.709 rs7942444 chr11:93637160 G/A cg26875233 chr11:93583750 C11orf90 0.29 5.15 0.3 5.2e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs863345 0.625 rs4575081 chr1:158504837 C/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs9905704 0.918 rs11656666 chr17:56929840 A/G cg12560992 chr17:57184187 TRIM37 0.61 7.05 0.4 1.54e-11 Testicular germ cell tumor; CESC cis rs7044106 0.762 rs3904197 chr9:123480378 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.94 0.34 9.08e-9 Hip circumference adjusted for BMI; CESC cis rs7917772 0.560 rs7912339 chr10:104373758 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.39 5.41 0.32 1.43e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1348850 0.526 rs2218575 chr2:178368997 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.68 6.17 0.35 2.52e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4474465 1.000 rs7124092 chr11:78155086 T/C cg27205649 chr11:78285834 NARS2 -0.42 -5.15 -0.3 4.98e-7 Alzheimer's disease (survival time); CESC trans rs9354308 0.901 rs12197136 chr6:66590953 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 7.62 0.42 4.41e-13 Metabolite levels; CESC cis rs12618769 0.597 rs2278214 chr2:99135738 A/G cg10123293 chr2:99228465 UNC50 -0.4 -5.24 -0.31 3.28e-7 Bipolar disorder; CESC cis rs1048238 0.506 rs10927866 chr1:16175317 C/T cg22431228 chr1:16359049 CLCNKA -0.36 -6.46 -0.37 4.99e-10 Systolic blood pressure; CESC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg19770292 chr5:1868693 NA 0.31 5.18 0.3 4.34e-7 Cardiovascular disease risk factors; CESC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg25072359 chr17:41440525 NA 0.48 7.31 0.41 3.19e-12 Menopause (age at onset); CESC cis rs8141529 0.719 rs6005916 chr22:29233342 T/C cg02153584 chr22:29168773 CCDC117 0.66 9.26 0.49 7.32e-18 Lymphocyte counts; CESC cis rs524281 0.731 rs78578425 chr11:65810239 G/A cg14036092 chr11:66035641 RAB1B -0.57 -5.17 -0.3 4.52e-7 Electroencephalogram traits; CESC cis rs1355223 0.506 rs11032898 chr11:34870111 C/G cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.64 -0.38 1.81e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg17724175 chr1:150552817 MCL1 0.38 5.85 0.34 1.42e-8 Melanoma; CESC cis rs76878669 0.754 rs10896113 chr11:66117111 C/T cg18002602 chr11:66138449 SLC29A2 -0.37 -5.07 -0.3 7.33e-7 Educational attainment (years of education); CESC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.72 0.62 2.99e-29 Alzheimer's disease; CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg12143784 chr7:64541923 NA 0.38 5.27 0.31 2.85e-7 Calcium levels; CESC cis rs854765 0.583 rs8065563 chr17:17782404 A/G cg04398451 chr17:18023971 MYO15A -0.63 -8.62 -0.47 6.07e-16 Total body bone mineral density; CESC cis rs12765878 1.000 rs12765878 chr10:105669622 C/T cg11005552 chr10:105648138 OBFC1 -0.35 -5.1 -0.3 6.53e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25195416 chr21:46696626 POFUT2 -0.61 -6.51 -0.37 3.81e-10 Gut microbiome composition (summer); CESC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg04553112 chr3:125709451 NA -0.51 -5.37 -0.31 1.7e-7 Blood pressure (smoking interaction); CESC cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg24308560 chr3:49941425 MST1R -0.56 -7.83 -0.43 1.19e-13 Body mass index; CESC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg19346786 chr7:2764209 NA -0.47 -7.07 -0.4 1.41e-11 Height; CESC cis rs75887402 0.793 rs10478580 chr5:122711168 C/T cg27033705 chr5:122759302 CEP120 0.93 6.12 0.35 3.32e-9 Breast cancer; CESC cis rs36051895 0.625 rs12340333 chr9:5176215 C/G cg02405213 chr9:5042618 JAK2 -0.5 -6.46 -0.37 5.09e-10 Pediatric autoimmune diseases; CESC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg07701084 chr6:150067640 NUP43 0.48 6.69 0.38 1.3e-10 Lung cancer; CESC cis rs977987 1.000 rs62060550 chr16:75502252 C/T cg03315344 chr16:75512273 CHST6 0.53 7.8 0.43 1.42e-13 Dupuytren's disease; CESC cis rs7267979 1.000 rs8125868 chr20:25324410 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -16.65 -0.71 4.48e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs6087771 0.642 rs6060403 chr20:30221104 C/A cg13852791 chr20:30311386 BCL2L1 0.67 7.77 0.43 1.7e-13 Subcortical brain region volumes;Putamen volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23285320 chr19:36546349 THAP8;WDR62 -0.47 -6.91 -0.39 3.67e-11 Gambling; CESC trans rs7246760 1.000 rs10419915 chr19:9890957 G/A cg02900749 chr2:68251473 NA -0.73 -6.78 -0.38 7.62e-11 Pursuit maintenance gain; CESC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.45 -0.37 5.28e-10 Bipolar disorder; CESC cis rs10927875 0.541 rs761759 chr1:16342350 A/T cg22431228 chr1:16359049 CLCNKA -0.52 -9.9 -0.52 7.22e-20 Dilated cardiomyopathy; CESC cis rs7208859 0.623 rs1061342 chr17:29114463 G/A cg14008862 chr17:28927542 LRRC37B2 0.66 5.26 0.31 2.93e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg09428623 chr2:68480128 PPP3R1 -0.49 -6.46 -0.37 4.9e-10 Height; CESC cis rs9487051 0.676 rs6929438 chr6:109595506 C/T cg01475377 chr6:109611718 NA -0.44 -7.02 -0.4 1.9e-11 Reticulocyte fraction of red cells; CESC cis rs1401999 1.000 rs4148579 chr3:183685249 T/C cg01324343 chr3:183735012 ABCC5 0.63 13.39 0.64 1.36e-31 Anterior chamber depth; CESC trans rs11039798 0.764 rs11039929 chr11:48703289 A/G cg15704280 chr7:45808275 SEPT13 0.69 6.29 0.36 1.33e-9 Axial length; CESC cis rs9916302 0.904 rs7501488 chr17:37576417 T/G cg20243544 chr17:37824526 PNMT 0.51 6.39 0.37 7.25e-10 Glomerular filtration rate (creatinine); CESC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg13206674 chr6:150067644 NUP43 0.39 5.51 0.32 8.53e-8 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03739129 chr2:220252547 DNPEP 0.48 6.0 0.35 6.61e-9 Gut microbiome composition (summer); CESC cis rs765787 0.530 rs11070451 chr15:45533541 T/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg03352830 chr11:487213 PTDSS2 0.73 7.02 0.4 1.85e-11 Body mass index; CESC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg23758822 chr17:41437982 NA 1.05 15.6 0.69 2.24e-39 Menopause (age at onset); CESC cis rs10822145 1 rs10822145 chr10:64934548 C/T cg01631684 chr10:65280961 REEP3 -0.46 -5.58 -0.32 6.01e-8 Triglycerides; CESC cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg07636037 chr3:49044803 WDR6 1.03 18.76 0.76 1.49e-50 Parkinson's disease; CESC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.25e-30 Prudent dietary pattern; CESC cis rs10484885 0.752 rs72921948 chr6:90582560 T/C cg13799429 chr6:90582589 CASP8AP2 -0.9 -11.56 -0.58 2.77e-25 QRS interval (sulfonylurea treatment interaction); CESC trans rs17685 0.753 rs55812043 chr7:75747241 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 11.92 0.59 1.67e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs7772486 0.875 rs1960885 chr6:146325930 G/T cg05347473 chr6:146136440 FBXO30 0.51 6.68 0.38 1.4e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs34779708 0.966 rs1057108 chr10:35484949 T/G cg03585969 chr10:35415529 CREM 0.76 9.94 0.52 5.54e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7647973 0.771 rs9865051 chr3:49166069 C/T cg06212747 chr3:49208901 KLHDC8B 0.56 6.05 0.35 5.05e-9 Menarche (age at onset); CESC cis rs17401966 0.838 rs17034643 chr1:10332102 A/G cg15208524 chr1:10270712 KIF1B -0.39 -5.13 -0.3 5.67e-7 Hepatocellular carcinoma; CESC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg06808227 chr14:105710500 BRF1 -0.56 -6.33 -0.36 1.04e-9 Mean platelet volume;Platelet distribution width; CESC cis rs959260 0.623 rs4542691 chr17:73326965 T/C cg20590849 chr17:73267439 MIF4GD -0.43 -5.27 -0.31 2.86e-7 Systemic lupus erythematosus; CESC cis rs7091068 0.522 rs866674 chr10:95487515 A/G cg20715218 chr10:95462985 C10orf4 0.52 6.01 0.35 6.1e-9 Urinary tract infection frequency; CESC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.02 0.56 1.64e-23 Alzheimer's disease; CESC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg03115019 chr17:80708279 FN3K -0.38 -5.63 -0.33 4.59e-8 Glycated hemoglobin levels; CESC trans rs4332037 0.802 rs12113633 chr7:1932936 G/A cg11693508 chr17:37793320 STARD3 0.64 6.17 0.35 2.59e-9 Bipolar disorder; CESC cis rs34779708 0.931 rs4351760 chr10:35280254 A/G cg03585969 chr10:35415529 CREM 0.77 10.3 0.53 3.84e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg22875332 chr1:76189707 ACADM -0.59 -6.77 -0.38 8.24e-11 Blood metabolite levels;Acylcarnitine levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02098460 chr2:114196058 CBWD2;LOC440839 -0.4 -6.06 -0.35 4.74e-9 Gambling; CESC cis rs10463316 0.832 rs246482 chr5:150731857 C/G cg03212797 chr5:150827313 SLC36A1 -0.42 -5.23 -0.31 3.48e-7 Metabolite levels (Pyroglutamine); CESC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC trans rs11770686 0.967 rs4728289 chr7:75348505 C/T cg10949413 chr6:26158832 HIST1H2BD -0.41 -6.16 -0.35 2.7e-9 Essential tremor; CESC cis rs7918232 0.800 rs7907981 chr10:27444329 T/C cg14442939 chr10:27389572 ANKRD26 0.72 7.9 0.44 7.57e-14 Breast cancer; CESC cis rs372883 0.648 rs15092 chr21:30718201 G/A cg08807101 chr21:30365312 RNF160 -0.45 -5.18 -0.3 4.39e-7 Pancreatic cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10483393 chr16:18573498 NOMO2 0.58 6.67 0.38 1.52e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05909891 chr12:19565983 NA 0.45 6.22 0.36 1.88e-9 Fibrinogen levels; CESC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg10691866 chr7:65817282 TPST1 0.3 5.05 0.3 8.38e-7 Aortic root size; CESC cis rs1967309 0.625 rs730242 chr16:4070433 C/T cg00061520 chr16:4070371 ADCY9 0.47 8.13 0.45 1.63e-14 Response to Dalcetrapib treatment in acute coronary syndrome; CESC cis rs7216064 1.000 rs4569324 chr17:65872750 C/T cg12091567 chr17:66097778 LOC651250 -0.84 -8.53 -0.46 1.13e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1215050 0.846 rs783923 chr4:98968686 C/T cg05340658 chr4:99064831 C4orf37 -0.54 -6.73 -0.38 1.06e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg26335602 chr6:28129616 ZNF389 0.47 6.17 0.35 2.51e-9 Parkinson's disease; CESC cis rs7917772 0.503 rs7100753 chr10:104300979 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.76 -0.33 2.3e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs644799 0.965 rs607039 chr11:95547086 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.95 10.4 0.54 1.85e-21 Mean platelet volume; CESC cis rs1559088 0.948 rs10406916 chr19:33590093 G/A cg17764715 chr19:33622953 WDR88 0.49 6.32 0.36 1.11e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2455799 0.613 rs11920540 chr3:15854608 G/A cg16303742 chr3:15540471 COLQ -0.37 -5.72 -0.33 2.8e-8 Mean platelet volume; CESC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg21770322 chr7:97807741 LMTK2 0.57 8.64 0.47 5.23e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs1707322 1.000 rs7532204 chr1:46485075 C/G cg05343316 chr1:45956843 TESK2 -0.45 -5.54 -0.32 7.32e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.76 -0.33 2.29e-8 Total body bone mineral density; CESC cis rs1707322 0.656 rs9429172 chr1:46092476 C/G cg05343316 chr1:45956843 TESK2 -0.52 -6.53 -0.37 3.41e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg03433033 chr1:76189801 ACADM 0.67 8.88 0.48 1.02e-16 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7799006 0.657 rs10447540 chr7:2301484 A/G cg08027265 chr7:2291960 NA -0.6 -10.21 -0.53 7.27e-21 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9611565 0.694 rs202622 chr22:41825342 T/G cg06481639 chr22:41940642 POLR3H 0.63 6.29 0.36 1.27e-9 Vitiligo; CESC cis rs10883723 0.810 rs10748823 chr10:104274465 C/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.76e-7 Allergic disease (asthma, hay fever or eczema); CESC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg03395511 chr6:291903 DUSP22 -0.71 -9.2 -0.49 1.13e-17 Menopause (age at onset); CESC cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg21782813 chr7:2030301 MAD1L1 0.44 6.36 0.36 8.79e-10 Schizophrenia; CESC cis rs3733585 0.638 rs28715627 chr4:9958140 T/A cg11266682 chr4:10021025 SLC2A9 -0.6 -11.09 -0.56 1.01e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2243480 1.000 rs7794661 chr7:65389730 T/C cg18252515 chr7:66147081 NA -1.09 -10.08 -0.53 1.87e-20 Diabetic kidney disease; CESC cis rs9457247 1.000 rs439237 chr6:167391392 A/G cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17361593 chr6:87831888 NA 0.44 6.11 0.35 3.48e-9 Fibrinogen levels; CESC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg18099408 chr3:52552593 STAB1 -0.36 -6.09 -0.35 4.06e-9 Electroencephalogram traits; CESC cis rs3781454 1 rs3781454 chr10:126348565 G/A cg20435097 chr10:126320824 FAM53B -0.27 -5.09 -0.3 6.72e-7 White blood cell count; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10267162 chr2:97001818 NCAPH 0.44 6.2 0.36 2.1e-9 Systemic lupus erythematosus; CESC cis rs2456568 0.802 rs10831139 chr11:93640537 G/A cg26875233 chr11:93583750 C11orf90 -0.29 -5.06 -0.3 7.7e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs763121 0.853 rs7289577 chr22:39042214 C/G cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.72 0.62 2.88e-29 Alzheimer's disease; CESC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg22823121 chr1:150693482 HORMAD1 0.47 6.96 0.39 2.6e-11 Tonsillectomy; CESC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.44 0.46 2.09e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4727963 0.792 rs59416413 chr7:122734516 C/A cg03640110 chr7:122635026 TAS2R16 -0.39 -5.96 -0.34 8.01e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12821679 chr2:27249349 MAPRE3 -0.51 -6.64 -0.38 1.74e-10 Gut microbiome composition (summer); CESC cis rs2668423 0.922 rs266805 chr19:1376723 C/T cg02639931 chr19:1387894 NDUFS7 -0.48 -6.81 -0.39 6.66e-11 Nonalcoholic fatty liver disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20777956 chr18:60987812 BCL2 0.56 6.13 0.35 3.17e-9 Gut microbiome composition (summer); CESC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg17427002 chr7:12443146 VWDE -0.53 -5.18 -0.3 4.34e-7 Coronary artery disease; CESC cis rs854765 0.547 rs6502632 chr17:17913057 A/G cg09796270 chr17:17721594 SREBF1 0.4 5.54 0.32 7.42e-8 Total body bone mineral density; CESC cis rs6460942 0.597 rs35589221 chr7:12535841 T/G cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs1670533 0.872 rs6854793 chr4:1055768 T/C cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.7e-7 Recombination rate (females); CESC cis rs4253772 0.514 rs11704878 chr22:46714664 C/T cg18190219 chr22:46762943 CELSR1 -0.6 -5.84 -0.34 1.5e-8 LDL cholesterol;Cholesterol, total; CESC cis rs1348850 0.874 rs1348848 chr2:178358233 A/C cg02961200 chr2:178257176 LOC100130691;AGPS -0.87 -13.05 -0.63 2.2e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7078219 0.524 rs1548963 chr10:101289703 C/G cg09788492 chr10:101292477 NKX2-3 0.32 6.11 0.35 3.45e-9 Dental caries; CESC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Tonsillectomy; CESC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg11890956 chr21:40555474 PSMG1 1.11 17.92 0.74 1.38e-47 Cognitive function; CESC cis rs12545109 0.643 rs1119707 chr8:57411548 T/C cg09654669 chr8:57350985 NA -0.54 -6.35 -0.36 9.45e-10 Obesity-related traits; CESC cis rs7246657 0.943 rs10420430 chr19:37894194 C/G cg23950597 chr19:37808831 NA -0.62 -6.27 -0.36 1.43e-9 Coronary artery calcification; CESC cis rs7246657 1.000 rs1529957 chr19:37739801 A/G cg23950597 chr19:37808831 NA -0.56 -6.1 -0.35 3.79e-9 Coronary artery calcification; CESC cis rs12079745 0.793 rs12063056 chr1:169264107 G/A cg09363564 chr1:169337483 NME7;BLZF1 -1.03 -6.26 -0.36 1.55e-9 QT interval; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg11897279 chr19:13044638 FARSA -0.47 -6.14 -0.35 3.01e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7923609 0.846 rs7073753 chr10:65062820 C/T cg01631684 chr10:65280961 REEP3 -0.42 -5.34 -0.31 1.96e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7208859 0.673 rs79541516 chr17:29240583 C/T cg19761014 chr17:28927070 LRRC37B2 0.73 5.78 0.33 2.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1153858 1.000 rs56806728 chr15:45637814 A/G cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg08736216 chr1:53307985 ZYG11A 0.32 5.74 0.33 2.59e-8 Monocyte count; CESC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.69 0.61 3.82e-29 Alzheimer's disease; CESC cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg06212747 chr3:49208901 KLHDC8B 0.71 9.61 0.51 5.83e-19 Parkinson's disease; CESC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg18876405 chr7:65276391 NA 0.47 6.28 0.36 1.4e-9 Aortic root size; CESC cis rs11252926 0.565 rs60553947 chr10:474284 T/C cg18196295 chr10:418757 DIP2C -0.53 -7.16 -0.4 7.94e-12 Psychosis in Alzheimer's disease; CESC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg05564831 chr3:52568323 NT5DC2 0.47 7.46 0.42 1.24e-12 Electroencephalogram traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04148091 chr16:81348876 GAN -0.48 -6.28 -0.36 1.35e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs35160687 0.644 rs4832265 chr2:86488265 A/G cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.22 -0.31 3.59e-7 Night sleep phenotypes; CESC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.47 0.77 5.16e-53 Height; CESC cis rs501120 0.925 rs535949 chr10:44752330 A/C cg09554077 chr10:44749378 NA -0.51 -6.71 -0.38 1.16e-10 Coronary artery disease;Coronary heart disease; CESC cis rs12291225 0.679 rs10832240 chr11:14304744 C/T cg19336497 chr11:14380999 RRAS2 -0.37 -5.29 -0.31 2.58e-7 Sense of smell; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14021555 chr22:43485536 TTLL1 0.46 6.02 0.35 5.71e-9 Gut microbiota (bacterial taxa); CESC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg20999797 chr1:1681921 NA 0.27 5.32 0.31 2.2e-7 Body mass index; CESC cis rs16917546 0.967 rs10995243 chr10:64391208 G/C cg03961010 chr10:64397487 ZNF365 -0.38 -6.15 -0.35 2.85e-9 Basal cell carcinoma; CESC cis rs7084402 0.967 rs1658434 chr10:60328756 G/C cg07615347 chr10:60278583 BICC1 0.59 9.2 0.49 1.08e-17 Refractive error; CESC cis rs909002 0.703 rs4949460 chr1:32143138 A/G cg13919466 chr1:32135498 COL16A1 0.34 5.9 0.34 1.13e-8 Intelligence (multi-trait analysis); CESC cis rs7202877 0.610 rs7202284 chr16:75374346 A/T cg04384234 chr16:75411784 CFDP1 -0.5 -6.01 -0.35 6.12e-9 Type 2 diabetes;Type 1 diabetes; CESC cis rs3749237 0.595 rs1464566 chr3:49459376 T/C cg06212747 chr3:49208901 KLHDC8B 0.51 6.87 0.39 4.52e-11 Resting heart rate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07385490 chr5:1318548 CLPTM1L -0.36 -6.15 -0.35 2.77e-9 Gambling; CESC cis rs7833790 0.777 rs1005850 chr8:82692255 G/A cg23324259 chr8:82754387 SNX16 -0.44 -5.11 -0.3 6.11e-7 Diastolic blood pressure; CESC cis rs7914558 1.000 rs6584540 chr10:104927634 A/G cg15744005 chr10:104629667 AS3MT -0.31 -5.04 -0.3 8.62e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs113835537 0.935 rs11550057 chr11:66392880 C/T cg24851651 chr11:66362959 CCS 0.62 5.6 0.33 5.26e-8 Airway imaging phenotypes; CESC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg25036284 chr2:26402008 FAM59B -0.58 -6.71 -0.38 1.16e-10 Gut microbiome composition (summer); CESC cis rs2070488 0.766 rs4679050 chr3:38482007 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.83 13.43 0.64 1e-31 Electrocardiographic conduction measures; CESC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg12412775 chr1:25698385 RHCE 0.29 5.21 0.3 3.76e-7 Erythrocyte sedimentation rate; CESC trans rs4927850 1.000 rs7625570 chr3:195747398 A/G cg16724585 chr3:197361211 NA -0.55 -6.95 -0.39 2.9e-11 Pancreatic cancer; CESC cis rs8092503 0.536 rs8091336 chr18:52378707 C/A cg12377874 chr18:52495404 RAB27B -0.34 -5.12 -0.3 5.84e-7 Childhood body mass index; CESC cis rs6963495 0.818 rs116457537 chr7:105152072 A/G cg19920283 chr7:105172520 RINT1 0.67 6.36 0.36 8.79e-10 Bipolar disorder (body mass index interaction); CESC cis rs11792861 0.926 rs56899598 chr9:111867271 A/G cg13535736 chr9:111863775 C9orf5 -0.5 -6.62 -0.38 1.96e-10 Menarche (age at onset); CESC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.41 -5.27 -0.31 2.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7959452 0.535 rs10784771 chr12:69621264 A/G cg20891283 chr12:69753455 YEATS4 0.75 10.83 0.55 7.16e-23 Blood protein levels; CESC cis rs7937 0.693 rs17726276 chr19:41291119 A/G cg09128733 chr19:41633906 CYP2F1 0.38 5.63 0.33 4.62e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Chronic obstructive pulmonary disease;Emphysema imaging phenotypes; CESC cis rs295137 0.836 rs10804097 chr2:201104924 A/T cg23649088 chr2:200775458 C2orf69 0.43 5.71 0.33 2.97e-8 Asthma (bronchodilator response); CESC cis rs2243480 1.000 rs316332 chr7:65604299 A/G cg12463550 chr7:65579703 CRCP 0.75 5.96 0.34 8.2e-9 Diabetic kidney disease; CESC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg04944784 chr2:26401820 FAM59B 0.96 10.5 0.54 8.76e-22 Gut microbiome composition (summer); CESC cis rs1847202 0.859 rs6805260 chr3:72933767 C/T cg25664220 chr3:72788482 NA -0.43 -6.36 -0.36 8.99e-10 Motion sickness; CESC cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7520050 0.966 rs11211230 chr1:46406767 G/T cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.64e-8 Red blood cell count;Reticulocyte count; CESC cis rs1707322 1.000 rs10890382 chr1:46469674 A/G cg03146154 chr1:46216737 IPP 0.76 10.05 0.53 2.46e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs977987 0.806 rs4888383 chr16:75386349 C/T cg03315344 chr16:75512273 CHST6 0.4 5.81 0.34 1.74e-8 Dupuytren's disease; CESC cis rs7703051 0.775 rs11957260 chr5:74608732 A/G cg03227963 chr5:74354835 NA -0.3 -5.51 -0.32 8.38e-8 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC trans rs875971 0.577 rs34888281 chr7:65585771 C/T cg26939375 chr7:64535504 NA -0.63 -8.33 -0.46 4.51e-15 Aortic root size; CESC cis rs2439831 1.000 rs2439850 chr15:43784854 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.83 11.92 0.59 1.68e-26 Lung cancer in ever smokers; CESC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg27266027 chr21:40555129 PSMG1 0.49 6.01 0.35 6.02e-9 Cognitive function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25005279 chr10:135113451 TUBGCP2 0.5 6.64 0.38 1.77e-10 Fibrinogen levels; CESC cis rs1065852 0.526 rs7290907 chr22:42390209 G/A cg22189786 chr22:42395067 WBP2NL 0.43 5.42 0.32 1.33e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg18477163 chr1:228402036 OBSCN 0.32 5.62 0.33 4.95e-8 Diastolic blood pressure; CESC cis rs3008870 0.583 rs2815369 chr1:67500894 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.99 10.98 0.56 2.3e-23 Lymphocyte percentage of white cells; CESC cis rs1153858 1.000 rs1049503 chr15:45653707 T/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.97 0.34 7.62e-9 Homoarginine levels; CESC cis rs651907 0.557 rs11917569 chr3:101355063 G/C cg12386194 chr3:101231763 SENP7 0.44 5.37 0.31 1.71e-7 Colorectal cancer; CESC cis rs7312933 0.558 rs1796381 chr12:42842475 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.53 7.14 0.4 9.03e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6582630 0.555 rs7305352 chr12:38473800 T/C cg26384229 chr12:38710491 ALG10B 0.72 10.64 0.55 3.12e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs8062405 0.964 rs9972768 chr16:28861734 A/C cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs939658 0.805 rs11638004 chr15:79425765 A/C cg17916960 chr15:79447300 NA -0.38 -6.29 -0.36 1.34e-9 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09377915 chr6:56295593 NA -0.6 -7.5 -0.42 9.8e-13 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg09699651 chr6:150184138 LRP11 0.4 5.12 0.3 5.83e-7 Lung cancer; CESC cis rs889398 0.742 rs12446197 chr16:69854869 A/G cg09409435 chr16:70099608 PDXDC2 -0.42 -5.22 -0.31 3.7e-7 Body mass index; CESC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg02951883 chr7:2050386 MAD1L1 -0.5 -6.46 -0.37 4.94e-10 Bipolar disorder and schizophrenia; CESC cis rs644799 1.000 rs3177463 chr11:95502128 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.94 14.84 0.67 1.14e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs1814175 0.817 rs10839465 chr11:49981554 C/A cg15704280 chr7:45808275 SEPT13 -1.03 -21.34 -0.8 1.71e-59 Height; CESC cis rs5753618 0.561 rs5753543 chr22:31685458 G/A cg13145458 chr22:31556086 RNF185 0.49 5.48 0.32 9.7e-8 Colorectal cancer; CESC cis rs7762018 0.607 rs7759404 chr6:170135728 A/G cg05834625 chr6:170176447 C6orf70 0.64 7.32 0.41 3.01e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg06074448 chr4:187884817 NA -0.37 -5.44 -0.32 1.21e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs17401966 0.800 rs2039778 chr1:10354601 A/G cg15208524 chr1:10270712 KIF1B 0.41 5.3 0.31 2.43e-7 Hepatocellular carcinoma; CESC cis rs2904967 0.636 rs184734 chr11:64982203 T/C cg23743554 chr11:65321226 LTBP3 -0.4 -5.17 -0.3 4.54e-7 Mean corpuscular volume; CESC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg07507251 chr3:52567010 NT5DC2 0.37 6.69 0.38 1.29e-10 Electroencephalogram traits; CESC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg26939375 chr7:64535504 NA 0.71 9.6 0.51 6.42e-19 Aortic root size; CESC cis rs7818345 1.000 rs4430112 chr8:19293365 G/A cg11303988 chr8:19266685 CSGALNACT1 0.35 6.31 0.36 1.16e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs5769765 0.913 rs2319462 chr22:50263370 C/T cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg21385522 chr1:16154831 NA 0.65 7.87 0.44 9.26e-14 Dilated cardiomyopathy; CESC cis rs78889164 0.840 rs3556 chr19:33878039 A/G cg02272751 chr19:33882848 PEPD -0.56 -8.07 -0.44 2.45e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg00031303 chr3:195681400 NA 0.42 5.26 0.31 2.98e-7 Pancreatic cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12665724 chr11:43364829 API5 -0.62 -7.51 -0.42 9.03e-13 Gut microbiome composition (summer); CESC cis rs7662987 0.517 rs1311615 chr4:100012261 G/A cg13256891 chr4:100009986 ADH5 0.75 8.06 0.44 2.55e-14 Smoking initiation; CESC trans rs17764205 0.777 rs28729385 chr19:3258882 T/C cg12868887 chr11:70244470 CTTN 0.72 6.0 0.35 6.46e-9 Bipolar disorder and schizophrenia; CESC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg07701084 chr6:150067640 NUP43 0.44 6.0 0.35 6.43e-9 Lung cancer; CESC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg14558114 chr2:88469736 THNSL2 0.57 5.4 0.31 1.5e-7 Plasma clusterin levels; CESC cis rs3733585 0.699 rs7694997 chr4:9947811 A/G cg00071950 chr4:10020882 SLC2A9 -0.72 -11.75 -0.59 6.35e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs854765 0.551 rs8070748 chr17:17859421 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC cis rs6088580 0.524 rs1853056 chr20:33262058 C/T cg24642439 chr20:33292090 TP53INP2 -0.45 -5.33 -0.31 2.08e-7 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.8 11.12 0.56 8.08e-24 Prudent dietary pattern; CESC cis rs12618769 0.597 rs3754891 chr2:99088018 T/C cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.68e-7 Bipolar disorder; CESC cis rs1577917 1.000 rs10455455 chr6:86670214 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.22 -0.36 1.91e-9 Response to antipsychotic treatment; CESC cis rs6582630 0.537 rs2204006 chr12:38407098 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.86 0.34 1.39e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs4332037 0.707 rs56070303 chr7:1891015 C/T cg11693508 chr17:37793320 STARD3 0.61 6.18 0.35 2.45e-9 Bipolar disorder; CESC trans rs208520 0.837 rs208471 chr6:66916749 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -10.02 -0.52 3.11e-20 Exhaled nitric oxide output; CESC cis rs1348850 0.645 rs11887886 chr2:178425730 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 6.48 0.37 4.41e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7818688 0.697 rs60003497 chr8:95983423 A/T cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9549260 0.755 rs7993233 chr13:41219434 T/A cg21288729 chr13:41239152 FOXO1 0.67 8.77 0.47 2.16e-16 Red blood cell count; CESC cis rs2299587 0.662 rs7816769 chr8:17768548 G/T cg08627089 chr8:17753878 FGL1 0.39 5.17 0.3 4.68e-7 Economic and political preferences; CESC cis rs7762018 0.891 rs7740218 chr6:170141552 G/A cg13891659 chr6:170190454 C6orf122;C6orf208 0.65 6.46 0.37 5e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg02079420 chr8:82753780 SNX16 -0.58 -7.73 -0.43 2.18e-13 Diastolic blood pressure; CESC cis rs367943 0.712 rs6594709 chr5:112700714 T/C cg12552261 chr5:112820674 MCC 0.4 5.31 0.31 2.31e-7 Type 2 diabetes; CESC trans rs801193 0.904 rs4718403 chr7:66242729 C/G cg14393609 chr7:65229607 NA 0.47 6.33 0.36 1.05e-9 Aortic root size; CESC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg06456125 chr7:65229604 NA -0.4 -5.17 -0.3 4.66e-7 Aortic root size; CESC cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg02487422 chr3:49467188 NICN1 0.4 5.11 0.3 6.09e-7 Parkinson's disease; CESC cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg12927641 chr6:109611667 NA -0.43 -6.67 -0.38 1.51e-10 Reticulocyte fraction of red cells; CESC cis rs13191362 0.507 rs2803051 chr6:163034979 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.5 -6.24 -0.36 1.74e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2997447 0.668 rs59978831 chr1:26446351 T/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.17 0.3 4.68e-7 QRS complex (12-leadsum); CESC cis rs5758659 0.652 rs133336 chr22:42416303 C/T cg15557168 chr22:42548783 NA -0.45 -6.71 -0.38 1.19e-10 Cognitive function; CESC cis rs7914558 1.000 rs12780843 chr10:104769335 G/C cg08650961 chr10:104748594 CNNM2 0.33 5.52 0.32 8e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs3815700 0.841 rs10410895 chr19:33093655 T/G cg02997394 chr19:33096574 ANKRD27 0.73 7.3 0.41 3.26e-12 Eosinophilic esophagitis; CESC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg23281280 chr6:28129359 ZNF389 0.5 6.56 0.37 2.75e-10 Parkinson's disease; CESC cis rs9916302 0.904 rs10852933 chr17:37698194 G/T cg00129232 chr17:37814104 STARD3 -0.57 -7.44 -0.42 1.39e-12 Glomerular filtration rate (creatinine); CESC trans rs1814175 0.791 rs10839395 chr11:49846274 G/T cg15704280 chr7:45808275 SEPT13 -1.03 -20.17 -0.78 1.78e-55 Height; CESC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg07414643 chr4:187882934 NA -0.55 -7.9 -0.44 7.43e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs3857067 0.806 rs28408270 chr4:95114572 G/T cg11021082 chr4:95130006 SMARCAD1 -0.65 -9.92 -0.52 6.18e-20 QT interval; CESC cis rs9300255 0.739 rs11057210 chr12:123733799 A/G cg00376283 chr12:123451042 ABCB9 0.7 8.61 0.47 6.56e-16 Neutrophil percentage of white cells; CESC cis rs6088580 0.543 rs4911158 chr20:33239512 T/C cg24642439 chr20:33292090 TP53INP2 -0.45 -5.36 -0.31 1.81e-7 Glomerular filtration rate (creatinine); CESC cis rs9815354 0.680 rs114714860 chr3:41882905 G/C cg03022575 chr3:42003672 ULK4 0.45 5.26 0.31 2.97e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7210086 0.768 rs4072716 chr17:70640933 T/C cg04206342 chr17:70636940 NA -0.3 -5.84 -0.34 1.56e-8 Ulcerative colitis; CESC cis rs28374715 0.662 rs513280 chr15:41482800 T/C cg18705301 chr15:41695430 NDUFAF1 0.76 10.17 0.53 1.02e-20 Ulcerative colitis; CESC cis rs9303280 0.901 rs12950743 chr17:38049233 T/C cg19468946 chr17:37922297 IKZF3 -0.41 -5.54 -0.32 7.41e-8 Self-reported allergy; CESC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg05754148 chr16:3507555 NAT15 0.67 7.46 0.42 1.24e-12 Tuberculosis; CESC cis rs8077577 0.747 rs62072537 chr17:18216100 G/A cg16794390 chr17:18148240 FLII 0.41 6.52 0.37 3.53e-10 Obesity-related traits; CESC cis rs7662987 0.517 rs2602881 chr4:100040695 A/G cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC cis rs7107174 1.000 rs2510032 chr11:77968631 G/C cg02023728 chr11:77925099 USP35 0.48 6.29 0.36 1.3e-9 Testicular germ cell tumor; CESC cis rs7539624 0.588 rs10916634 chr1:223913858 C/T cg10100437 chr1:223903862 CAPN2 0.37 5.16 0.3 4.74e-7 Schizophrenia; CESC cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg13147721 chr7:65941812 NA -0.88 -8.52 -0.46 1.19e-15 Diabetic kidney disease; CESC trans rs7618501 0.633 rs2624843 chr3:49997963 G/A cg21659725 chr3:3221576 CRBN 0.49 6.81 0.39 6.69e-11 Intelligence (multi-trait analysis); CESC cis rs763121 0.853 rs2284073 chr22:39105948 T/C cg06544989 chr22:39130855 UNC84B 0.51 9.82 0.52 1.27e-19 Menopause (age at onset); CESC cis rs75477785 0.590 rs11119394 chr1:210194685 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.91 6.32 0.36 1.09e-9 Cleft lip with or without cleft palate; CESC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg18538332 chr22:24372958 LOC391322 -0.73 -10.57 -0.54 5.23e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs16910800 0.689 rs56101126 chr11:23188861 T/A cg20040320 chr11:23191996 NA -0.67 -6.66 -0.38 1.53e-10 Cancer; CESC cis rs9916302 0.904 rs3744348 chr17:37417575 C/G cg15445000 chr17:37608096 MED1 0.4 6.52 0.37 3.63e-10 Glomerular filtration rate (creatinine); CESC cis rs9649213 0.727 rs12113294 chr7:97910637 C/G cg24562669 chr7:97807699 LMTK2 0.37 5.09 0.3 6.95e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg09035930 chr12:129282057 SLC15A4 -0.67 -8.94 -0.48 6.63e-17 Systemic lupus erythematosus; CESC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.96e-7 Life satisfaction; CESC cis rs9905704 0.647 rs2286299 chr17:57043367 T/G cg12560992 chr17:57184187 TRIM37 0.62 7.93 0.44 6.35e-14 Testicular germ cell tumor; CESC cis rs6088580 0.524 rs6142210 chr20:33223012 C/T cg06115741 chr20:33292138 TP53INP2 -0.45 -5.25 -0.31 3.14e-7 Glomerular filtration rate (creatinine); CESC trans rs17685 0.712 rs10952842 chr7:75780413 G/A cg19862616 chr7:65841803 NCRNA00174 0.8 11.44 0.57 6.89e-25 Coffee consumption;Coffee consumption (cups per day); CESC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg17221315 chr6:27791827 HIST1H4J 0.44 5.29 0.31 2.61e-7 Parkinson's disease; CESC cis rs7301826 0.651 rs1973834 chr12:131280157 C/T cg11011512 chr12:131303247 STX2 0.47 5.73 0.33 2.69e-8 Plasma plasminogen activator levels; CESC cis rs1580019 0.563 rs4723169 chr7:32567577 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.61 0.38 2.16e-10 Cognitive ability; CESC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs11638352 0.661 rs2706490 chr15:44422238 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -5.29 -0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs2180341 0.960 rs9401953 chr6:127687574 G/A cg24812749 chr6:127587940 RNF146 1.05 15.12 0.68 1.2e-37 Breast cancer; CESC cis rs7000551 0.689 rs10110254 chr8:22309551 G/T cg12081754 chr8:22256438 SLC39A14 0.41 5.45 0.32 1.16e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs9430161 0.611 rs34032547 chr1:11034374 C/G cg27631724 chr1:11040367 C1orf127 0.38 6.21 0.36 2.02e-9 Ewing sarcoma; CESC cis rs6466055 0.748 rs1204080 chr7:104988848 A/G cg04380332 chr7:105027541 SRPK2 0.43 5.6 0.33 5.33e-8 Schizophrenia; CESC cis rs703842 1.000 rs10877019 chr12:58172929 A/G cg04478727 chr12:58166393 METTL1;FAM119B -0.72 -8.88 -0.48 1.07e-16 Multiple sclerosis; CESC cis rs12477438 0.520 rs2516829 chr2:99773201 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.18 0.68 6.93e-38 Chronic sinus infection; CESC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg06494592 chr3:125709126 NA -0.5 -5.31 -0.31 2.38e-7 Blood pressure (smoking interaction); CESC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg25985355 chr7:65971099 NA 0.33 5.52 0.32 7.94e-8 Aortic root size; CESC cis rs1865760 0.532 rs9295687 chr6:26082710 T/C cg17691542 chr6:26056736 HIST1H1C 0.42 5.57 0.32 6.13e-8 Height; CESC cis rs34286592 1.000 rs28599680 chr16:29860685 A/C cg27338089 chr16:29820515 MAZ 0.48 5.04 0.3 8.68e-7 Multiple sclerosis; CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg23034840 chr1:205782522 SLC41A1 0.68 8.32 0.46 4.7e-15 Menarche (age at onset); CESC cis rs2115630 0.967 rs10438428 chr15:85330745 C/T cg09876464 chr15:85330779 ZNF592 0.36 5.6 0.33 5.38e-8 P wave terminal force; CESC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg13147721 chr7:65941812 NA 0.38 5.36 0.31 1.77e-7 Aortic root size; CESC trans rs7726839 0.540 rs12520279 chr5:657291 T/C cg25482853 chr8:67687455 SGK3 0.93 9.54 0.51 9.85e-19 Obesity-related traits; CESC cis rs7949030 0.688 rs2849031 chr11:62365665 G/A cg23462726 chr11:62437636 C11orf83;C11orf48 0.41 5.42 0.32 1.33e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg04518342 chr5:131593106 PDLIM4 0.4 5.95 0.34 8.64e-9 Acylcarnitine levels; CESC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg08027265 chr7:2291960 NA -0.45 -6.96 -0.39 2.71e-11 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02415717 chr17:45727607 KPNB1 0.57 6.74 0.38 1e-10 Gut microbiome composition (summer); CESC trans rs7246657 0.943 rs3760825 chr19:37945601 C/T cg24637308 chr11:6592297 DNHD1 0.54 6.34 0.36 1.01e-9 Coronary artery calcification; CESC cis rs7212590 0.748 rs59685433 chr17:57891207 T/C cg20303301 chr17:57937339 TUBD1 -0.59 -5.56 -0.32 6.49e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.48 -0.37 4.36e-10 Depression; CESC cis rs763014 0.865 rs2018789 chr16:632051 T/C cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC cis rs1008375 0.966 rs3796812 chr4:17582051 G/A cg16339924 chr4:17578868 LAP3 0.62 7.84 0.43 1.09e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg10691866 chr7:65817282 TPST1 0.3 5.07 0.3 7.66e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07120479 chr11:67033799 ADRBK1 0.59 6.61 0.38 2.07e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10332367 chr16:2075476 SLC9A3R2 0.38 6.09 0.35 4.06e-9 Fibrinogen levels; CESC cis rs7511006 0.893 rs5771104 chr22:50651839 C/T cg07895657 chr22:50616420 PANX2 -0.36 -5.67 -0.33 3.69e-8 Obesity-related traits; CESC cis rs2066819 1.000 rs773664 chr12:56702176 C/T cg26734620 chr12:56694298 CS -0.92 -9.33 -0.5 4.31e-18 Psoriasis vulgaris; CESC cis rs524023 0.874 rs518053 chr11:64456099 C/T cg07220939 chr11:64358617 SLC22A12 -0.35 -5.42 -0.32 1.36e-7 Urate levels in obese individuals; CESC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.81 10.39 0.54 1.89e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09820084 chr6:18387507 RNF144B 0.43 6.0 0.35 6.61e-9 Systemic lupus erythematosus; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14765172 chr6:153304972 FBXO5 -0.52 -7.23 -0.41 5.29e-12 Gut microbiota (bacterial taxa); CESC cis rs2243480 1.000 rs9769882 chr7:65642925 T/C cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.24e-32 Diabetic kidney disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C ch.19.702771R chr19:16673058 SLC35E1 -0.45 -6.17 -0.35 2.61e-9 Asthma; CESC cis rs2486288 0.656 rs9920290 chr15:45548035 G/A cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.54 -0.37 3.21e-10 Glomerular filtration rate; CESC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg11663144 chr21:46675770 NA -0.63 -9.96 -0.52 4.72e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2637266 1.000 rs11001830 chr10:78346396 G/A cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.54e-13 Pulmonary function; CESC cis rs7100689 0.646 rs10736345 chr10:82134140 C/T cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs2991971 0.810 rs781058 chr1:45935056 C/G cg24296786 chr1:45957014 TESK2 -0.63 -9.17 -0.49 1.39e-17 High light scatter reticulocyte count; CESC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg19163074 chr7:65112434 INTS4L2 -0.42 -5.26 -0.31 2.93e-7 Aortic root size; CESC cis rs6060717 0.536 rs11697024 chr20:34546500 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.13 -0.4 9.32e-12 Hip circumference adjusted for BMI; CESC cis rs7116495 0.881 rs615000 chr11:71802952 A/C cg10381502 chr11:71823885 C11orf51 -0.64 -5.12 -0.3 5.87e-7 Severe influenza A (H1N1) infection; CESC cis rs61542988 0.570 rs7781074 chr7:22826360 A/G cg11367502 chr7:22862612 TOMM7 -0.52 -6.14 -0.35 2.99e-9 Fibrinogen levels; CESC cis rs7264396 0.790 rs6060526 chr20:34225302 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.59 -6.43 -0.37 5.81e-10 Total cholesterol levels; CESC cis rs9768139 0.708 rs10234067 chr7:158114542 C/T cg06219351 chr7:158114137 PTPRN2 -0.56 -8.96 -0.48 5.77e-17 Calcium levels; CESC cis rs7267979 1.000 rs6107047 chr20:25442097 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.83 15.81 0.7 4.28e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs7605827 0.930 rs10929376 chr2:15692856 A/T cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs17253792 0.915 rs74580958 chr14:56181511 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.74 5.1 0.3 6.53e-7 Putamen volume; CESC cis rs425277 0.565 rs3128293 chr1:2065339 A/G cg19257562 chr1:2043853 PRKCZ 0.34 5.35 0.31 1.95e-7 Height; CESC cis rs12145833 0.538 rs10754798 chr1:243309958 A/G cg02356786 chr1:243265016 LOC731275 -0.69 -6.44 -0.37 5.61e-10 Obesity (early onset extreme); CESC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg01448562 chr3:133502909 NA -0.59 -8.58 -0.47 7.98e-16 Iron status biomarkers; CESC cis rs4148883 0.504 rs9307238 chr4:100136182 A/G cg13256891 chr4:100009986 ADH5 -0.51 -6.88 -0.39 4.27e-11 Alcohol dependence; CESC cis rs72781680 0.611 rs72783636 chr2:24328706 C/T cg08917208 chr2:24149416 ATAD2B 0.55 5.3 0.31 2.47e-7 Lymphocyte counts; CESC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg09323728 chr8:95962352 TP53INP1 -0.39 -8.53 -0.46 1.11e-15 Type 2 diabetes; CESC cis rs12586317 0.548 rs12590678 chr14:35602956 C/T cg16230307 chr14:35515116 FAM177A1 1.03 11.3 0.57 2e-24 Psoriasis; CESC cis rs4474465 0.850 rs4482052 chr11:78263331 A/G cg27205649 chr11:78285834 NARS2 0.43 5.31 0.31 2.3e-7 Alzheimer's disease (survival time); CESC cis rs12681366 0.663 rs2930970 chr8:95464337 A/G cg13257157 chr8:95487014 RAD54B 0.39 5.34 0.31 2.04e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg06212747 chr3:49208901 KLHDC8B 0.73 11.08 0.56 1.07e-23 Menarche (age at onset); CESC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg25767906 chr1:53392781 SCP2 -0.45 -5.7 -0.33 3.19e-8 Monocyte count; CESC cis rs72945132 0.882 rs7928686 chr11:70134528 T/C cg14191688 chr11:70257035 CTTN 0.41 5.19 0.3 4.24e-7 Coronary artery disease; CESC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.15 0.35 2.87e-9 Bipolar disorder; CESC cis rs7267979 0.966 rs6037103 chr20:25369095 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.5 -0.71 1.44e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs7769051 0.522 rs34688576 chr6:133118214 C/T cg07930552 chr6:133119739 C6orf192 1.14 7.79 0.43 1.5e-13 Type 2 diabetes nephropathy; CESC cis rs780096 0.647 rs11682083 chr2:27752296 A/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.66 -0.33 3.99e-8 Total body bone mineral density; CESC cis rs7916697 0.520 rs4745957 chr10:70044702 A/G cg06988349 chr10:69991859 ATOH7 -0.31 -5.08 -0.3 7.01e-7 Optic disc area; CESC cis rs524281 0.773 rs4393319 chr11:66001878 A/T cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.38e-7 Electroencephalogram traits; CESC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg07677032 chr17:61819896 STRADA 0.42 5.23 0.31 3.42e-7 Height; CESC cis rs2228479 0.850 rs11639925 chr16:89908250 C/T cg04013166 chr16:89971882 TCF25 0.73 5.8 0.34 1.93e-8 Skin colour saturation; CESC cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg04455712 chr21:45112962 RRP1B 0.4 5.9 0.34 1.08e-8 Mean corpuscular volume; CESC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg12288994 chr5:1860383 NA 0.42 7.0 0.4 2.04e-11 Cardiovascular disease risk factors; CESC cis rs10751667 0.666 rs7396473 chr11:966181 T/C cg20946044 chr11:1010712 AP2A2 -0.4 -5.46 -0.32 1.12e-7 Alzheimer's disease (late onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16773294 chr8:55048378 MRPL15 0.45 6.32 0.36 1.08e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10032549 0.627 rs10002170 chr4:77394139 G/C cg20311846 chr4:77356250 SHROOM3 -0.26 -5.21 -0.3 3.87e-7 Glomerular filtration rate; CESC cis rs6754311 0.551 rs2304599 chr2:136528004 C/G cg15123519 chr2:136567270 LCT 0.32 5.63 0.33 4.67e-8 Mosquito bite size; CESC cis rs9910055 0.552 rs4793084 chr17:42317371 G/T cg13607699 chr17:42295918 UBTF -0.85 -12.32 -0.6 6.83e-28 Total body bone mineral density; CESC trans rs116095464 0.558 rs62344300 chr5:246336 A/G cg00938859 chr5:1591904 SDHAP3 0.64 6.98 0.39 2.36e-11 Breast cancer; CESC cis rs72634258 0.786 rs4405150 chr1:8173672 T/C cg00042356 chr1:8021962 PARK7 -0.55 -5.93 -0.34 9.19e-9 Inflammatory bowel disease; CESC cis rs9896933 0.732 rs590886 chr17:80767350 A/G cg20578329 chr17:80767326 TBCD 0.73 8.42 0.46 2.38e-15 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs1707322 0.721 rs10430123 chr1:46221440 T/C cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg01420254 chr6:26195488 NA -0.73 -6.84 -0.39 5.54e-11 Gout;Renal underexcretion gout; CESC cis rs17001868 0.527 rs11913132 chr22:40778778 A/G cg07138101 chr22:40742427 ADSL 0.49 5.22 0.31 3.58e-7 Mammographic density (dense area); CESC cis rs10751667 0.666 rs7936830 chr11:959686 A/G cg06064525 chr11:970664 AP2A2 -0.47 -9.44 -0.5 2.07e-18 Alzheimer's disease (late onset); CESC cis rs853679 0.882 rs9468287 chr6:28079741 G/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.79 7.22 0.41 5.41e-12 Depression; CESC cis rs4780401 0.587 rs9931332 chr16:11807517 G/C cg01061890 chr16:11836724 TXNDC11 -0.56 -7.59 -0.42 5.42e-13 Rheumatoid arthritis; CESC cis rs7584330 0.737 rs10445707 chr2:238368751 A/G cg14458575 chr2:238380390 NA 0.64 8.87 0.48 1.14e-16 Prostate cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05889321 chr10:97416837 ALDH18A1 0.51 6.65 0.38 1.65e-10 Gut microbiota (bacterial taxa); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12474080 chr11:60929017 VPS37C 0.44 6.16 0.35 2.64e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs428668 0.523 rs10060607 chr5:150679304 A/C cg11125805 chr5:150678162 SLC36A3 0.69 10.91 0.56 3.83e-23 Skin aging (microtopography measurement); CESC cis rs858239 0.539 rs7791200 chr7:23182121 A/T cg23682824 chr7:23144976 KLHL7 0.52 6.73 0.38 1.04e-10 Cerebrospinal fluid biomarker levels; CESC cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg02034447 chr16:89574710 SPG7 -0.48 -5.75 -0.33 2.42e-8 Multiple myeloma (IgH translocation); CESC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg13733410 chr7:12443478 VWDE -0.53 -5.47 -0.32 1.02e-7 Coronary artery disease; CESC cis rs2836633 1.000 rs2836631 chr21:40065906 G/T cg12884169 chr21:40033163 ERG -0.33 -5.47 -0.32 1.05e-7 Coronary artery disease; CESC trans rs9325144 0.513 rs12313652 chr12:38665412 G/A cg23762105 chr12:34175262 ALG10 0.48 6.31 0.36 1.15e-9 Morning vs. evening chronotype; CESC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.21e-8 Lung cancer; CESC cis rs10779751 0.922 rs2746638 chr1:11278125 T/C cg08854313 chr1:11322531 MTOR 0.79 10.75 0.55 1.32e-22 Body mass index; CESC cis rs941408 1.000 rs1736180 chr19:2796021 C/T cg00079169 chr19:2811669 THOP1 0.45 6.44 0.37 5.47e-10 Total cholesterol levels; CESC cis rs829883 0.664 rs249833 chr12:98832189 T/C cg25150519 chr12:98850993 NA 0.87 14.77 0.67 1.95e-36 Colorectal adenoma (advanced); CESC cis rs854765 0.547 rs4643387 chr17:17972973 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 7.98 0.44 4.39e-14 Total body bone mineral density; CESC cis rs7829975 0.564 rs2976855 chr8:8301794 G/A cg15556689 chr8:8085844 FLJ10661 0.62 7.95 0.44 5.39e-14 Mood instability; CESC cis rs6831352 0.819 rs1230158 chr4:99990186 T/C cg13256891 chr4:100009986 ADH5 0.69 8.15 0.45 1.43e-14 Alcohol dependence; CESC trans rs7980799 0.967 rs7971226 chr12:33586881 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.21 0.4 5.74e-12 Heart rate;Heart rate variability traits (RMSSD); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07175945 chr5:32444062 ZFR 0.62 6.4 0.37 6.98e-10 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23093116 chr1:117489843 PTGFRN 0.45 6.45 0.37 5.41e-10 Gut microbiota (bacterial taxa); CESC cis rs1355223 0.506 rs7947848 chr11:34866220 T/C cg11058730 chr11:34937778 PDHX;APIP -0.54 -6.72 -0.38 1.12e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg22968622 chr17:43663579 NA -1.19 -16.52 -0.71 1.26e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1801251 0.656 rs10211596 chr2:233699415 C/T cg25237894 chr2:233734115 C2orf82 -0.29 -5.1 -0.3 6.48e-7 Coronary artery disease; CESC cis rs6429082 0.818 rs167092 chr1:235642359 A/G cg26050004 chr1:235667680 B3GALNT2 0.62 7.83 0.43 1.19e-13 Adiposity; CESC cis rs262150 1.000 rs262149 chr7:158778256 A/G cg19418458 chr7:158789849 NA 0.45 7.05 0.4 1.52e-11 Facial morphology (factor 20); CESC cis rs7216064 1.000 rs1976053 chr17:65833002 C/G cg07042672 chr17:66097459 LOC651250 -0.63 -7.92 -0.44 6.66e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg11644478 chr21:40555479 PSMG1 -0.8 -11.67 -0.58 1.12e-25 Cognitive function; CESC cis rs6546550 0.935 rs4853027 chr2:70039224 A/G cg02498382 chr2:70120550 SNRNP27 0.39 6.98 0.39 2.36e-11 Prevalent atrial fibrillation; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16954204 chr6:20212978 MBOAT1 -0.47 -6.33 -0.36 1.05e-9 Asthma; CESC trans rs1814175 0.935 rs11040438 chr11:49622521 G/A cg03929089 chr4:120376271 NA -0.87 -13.32 -0.63 2.44e-31 Height; CESC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg18404041 chr3:52824283 ITIH1 -0.37 -5.1 -0.3 6.38e-7 Bipolar disorder; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg14771734 chr5:79703670 ZFYVE16 0.46 6.01 0.35 6.03e-9 Attention deficit hyperactivity disorder; CESC cis rs9322193 0.962 rs2065664 chr6:150083621 A/G cg07701084 chr6:150067640 NUP43 0.39 5.24 0.31 3.36e-7 Lung cancer; CESC cis rs1005277 0.522 rs289650 chr10:37975505 G/T cg00409905 chr10:38381863 ZNF37A -0.48 -6.64 -0.38 1.75e-10 Extrinsic epigenetic age acceleration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23490046 chr20:18487999 SEC23B 0.45 6.07 0.35 4.36e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg21285383 chr16:89894308 SPIRE2 0.32 5.74 0.33 2.6e-8 Vitiligo; CESC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg09323728 chr8:95962352 TP53INP1 -0.39 -8.29 -0.45 5.87e-15 Type 2 diabetes; CESC cis rs7259376 0.905 rs8112246 chr19:22567447 C/T cg02657401 chr19:22469223 NA -0.25 -5.11 -0.3 6.31e-7 Menopause (age at onset); CESC cis rs1395 0.778 rs11126918 chr2:27438710 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 5.8 0.34 1.84e-8 Blood metabolite levels; CESC cis rs3741151 1.000 rs7129663 chr11:73045129 C/T cg17517138 chr11:73019481 ARHGEF17 1.07 7.35 0.41 2.52e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs2228479 0.541 rs9922515 chr16:89954138 G/C cg04013166 chr16:89971882 TCF25 0.71 8.73 0.47 2.95e-16 Skin colour saturation; CESC cis rs10751667 0.643 rs10902238 chr11:944810 G/A cg06064525 chr11:970664 AP2A2 -0.52 -10.45 -0.54 1.21e-21 Alzheimer's disease (late onset); CESC cis rs35306767 0.855 rs12781100 chr10:838636 C/T cg10556349 chr10:835070 NA 0.7 6.04 0.35 5.24e-9 Eosinophil percentage of granulocytes; CESC cis rs62064224 0.703 rs62065492 chr17:30822607 C/T cg12855166 chr17:30846586 MYO1D 0.4 5.12 0.3 6.02e-7 Schizophrenia; CESC cis rs709400 0.663 rs3742458 chr14:103950368 A/G cg12935359 chr14:103987150 CKB -0.51 -7.44 -0.42 1.39e-12 Body mass index; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg15448590 chr17:655563 ELP2P;GEMIN4 0.48 6.13 0.35 3.15e-9 Bronchopulmonary dysplasia; CESC cis rs3820068 0.603 rs3766163 chr1:15986547 T/C cg13390004 chr1:15929781 NA 0.34 5.47 0.32 1.04e-7 Systolic blood pressure; CESC cis rs763014 0.865 rs710924 chr16:633353 T/C cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25312481 chr1:10459146 PGD 0.59 6.91 0.39 3.65e-11 Gut microbiome composition (summer); CESC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg24675658 chr1:53192096 ZYG11B 0.53 6.78 0.38 7.96e-11 Monocyte count; CESC cis rs863345 0.604 rs7548349 chr1:158493726 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.75e-11 Pneumococcal bacteremia; CESC cis rs9623117 1.000 rs713639 chr22:40507282 T/C cg05033341 chr22:40419857 FAM83F -0.42 -5.13 -0.3 5.57e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs1620921 0.505 rs4708881 chr6:161203159 C/T cg01280913 chr6:161186852 NA -0.36 -5.26 -0.31 2.92e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg02462569 chr6:150064036 NUP43 -0.36 -5.11 -0.3 6.15e-7 Lung cancer; CESC cis rs6088590 1.000 rs1998028 chr20:33344595 A/T cg24642439 chr20:33292090 TP53INP2 0.85 11.81 0.59 3.81e-26 Coronary artery disease; CESC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg25517755 chr10:38738941 LOC399744 -0.49 -6.35 -0.36 9.08e-10 Extrinsic epigenetic age acceleration; CESC trans rs11039798 0.698 rs76315297 chr11:48240475 T/C cg15704280 chr7:45808275 SEPT13 0.71 6.58 0.37 2.49e-10 Axial length; CESC cis rs9837602 0.507 rs6803204 chr3:99680874 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.59 -7.14 -0.4 8.97e-12 Breast cancer; CESC cis rs4472734 1.000 rs4615815 chr1:214604236 A/G cg00063699 chr1:214624242 PTPN14 -0.34 -5.43 -0.32 1.26e-7 Height; CESC cis rs258892 0.739 rs34667 chr5:72160050 T/C cg21869765 chr5:72125136 TNPO1 0.44 5.55 0.32 6.92e-8 Small cell lung carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11987090 chr1:22778442 ZBTB40 -0.64 -7.54 -0.42 7.31e-13 Gut microbiome composition (summer); CESC cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg23158103 chr7:148848205 ZNF398 -0.4 -6.32 -0.36 1.09e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3781458 0.806 rs3781466 chr10:126328689 A/G cg20435097 chr10:126320824 FAM53B -0.31 -5.79 -0.34 1.96e-8 Male-pattern baldness; CESC cis rs3820928 1.000 rs1346618 chr2:227771988 C/T cg11843606 chr2:227700838 RHBDD1 0.42 5.65 0.33 4.16e-8 Pulmonary function; CESC trans rs2727020 0.638 rs1164668 chr11:49330627 A/C cg03929089 chr4:120376271 NA 0.79 11.67 0.58 1.14e-25 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03442064 chr6:41515050 FOXP4 -0.43 -6.51 -0.37 3.85e-10 Gambling; CESC cis rs34779708 0.677 rs112355105 chr10:35550294 A/T cg03585969 chr10:35415529 CREM 0.55 6.25 0.36 1.61e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22455250 chr17:73559202 LLGL2 0.44 6.45 0.37 5.43e-10 Fibrinogen levels; CESC cis rs798766 1.000 rs3099555 chr4:1725651 T/C cg07041428 chr4:1763019 NA -0.41 -5.78 -0.33 2.05e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs2066819 1.000 rs2695789 chr12:56694261 C/A cg26316697 chr12:56727976 PAN2 -0.69 -6.64 -0.38 1.74e-10 Psoriasis vulgaris; CESC cis rs7312933 0.703 rs12371615 chr12:42563989 C/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.28 0.36 1.39e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs10504073 0.527 rs118032023 chr8:49926296 A/T cg00325661 chr8:49890786 NA 0.53 8.13 0.45 1.62e-14 Blood metabolite ratios; CESC cis rs1055129 0.655 rs7216615 chr17:73833910 T/C cg08125733 chr17:73851984 WBP2 0.52 7.05 0.4 1.51e-11 White matter hyperintensity burden; CESC cis rs7727544 0.660 rs272886 chr5:131665840 T/C cg24060327 chr5:131705240 SLC22A5 -0.68 -8.94 -0.48 6.91e-17 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06753869 chr6:24667316 ACOT13;TTRAP 0.53 6.24 0.36 1.77e-9 Gut microbiome composition (summer); CESC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg21951975 chr1:209979733 IRF6 0.62 7.7 0.43 2.7e-13 Cleft lip with or without cleft palate; CESC trans rs11098499 0.909 rs7681214 chr4:120385320 C/A cg25214090 chr10:38739885 LOC399744 0.7 9.93 0.52 5.63e-20 Corneal astigmatism; CESC cis rs763121 0.853 rs35522482 chr22:39063015 C/A cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.58e-7 Menopause (age at onset); CESC cis rs2486288 0.656 rs62026703 chr15:45569929 G/T cg09092052 chr15:45571596 NA 0.45 5.33 0.31 2.14e-7 Glomerular filtration rate; CESC cis rs6570726 0.935 rs408723 chr6:145838535 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1395 0.744 rs11686131 chr2:27508710 C/T cg22903471 chr2:27725779 GCKR -0.5 -6.08 -0.35 4.12e-9 Blood metabolite levels; CESC cis rs1707322 0.717 rs2991989 chr1:46082965 C/T cg06784218 chr1:46089804 CCDC17 -0.41 -7.08 -0.4 1.31e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6740322 0.895 rs10196095 chr2:43571885 G/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -6.93 -0.39 3.28e-11 Coronary artery disease; CESC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg09658497 chr7:2847517 GNA12 -0.47 -7.33 -0.41 2.76e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs3733585 0.699 rs6449176 chr4:9967843 G/A cg11266682 chr4:10021025 SLC2A9 -0.58 -10.94 -0.56 3.03e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg07507251 chr3:52567010 NT5DC2 0.41 7.3 0.41 3.28e-12 Bipolar disorder; CESC cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg05340658 chr4:99064831 C4orf37 0.74 10.67 0.55 2.44e-22 Colonoscopy-negative controls vs population controls; CESC cis rs2952156 0.876 rs903501 chr17:37839493 T/C cg07936489 chr17:37558343 FBXL20 -0.53 -6.45 -0.37 5.41e-10 Asthma; CESC cis rs8141529 0.702 rs5762870 chr22:29261159 C/T cg15103426 chr22:29168792 CCDC117 0.61 8.18 0.45 1.21e-14 Lymphocyte counts; CESC cis rs7107174 0.892 rs4945273 chr11:78096977 T/C cg02023728 chr11:77925099 USP35 0.47 6.23 0.36 1.83e-9 Testicular germ cell tumor; CESC cis rs4566357 0.615 rs2272200 chr2:227912331 G/A cg11843606 chr2:227700838 RHBDD1 -0.48 -6.59 -0.38 2.37e-10 Coronary artery disease; CESC cis rs7116495 0.786 rs1573501 chr11:71735693 C/T cg07596299 chr11:71824057 C11orf51 -0.85 -5.06 -0.3 7.92e-7 Severe influenza A (H1N1) infection; CESC cis rs250677 0.687 rs40523 chr5:148444186 A/T cg18129178 chr5:148520854 ABLIM3 0.5 5.84 0.34 1.53e-8 Breast cancer; CESC cis rs10823500 0.674 rs7089860 chr10:71992848 C/G cg04118878 chr10:71993077 PPA1 0.51 5.97 0.34 7.56e-9 Blood protein levels; CESC cis rs1355223 0.902 rs1773908 chr11:34743380 A/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.44 -0.37 5.45e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg12463550 chr7:65579703 CRCP -0.5 -6.34 -0.36 9.71e-10 Aortic root size; CESC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg16545954 chr1:2118288 C1orf86 0.36 7.1 0.4 1.13e-11 Height; CESC cis rs910316 1.000 rs4899544 chr14:75546556 C/T cg08847533 chr14:75593920 NEK9 0.99 18.86 0.76 6.94e-51 Height; CESC cis rs2276314 0.857 rs16967327 chr18:33587036 C/T cg19628046 chr18:33552617 C18orf21 0.51 5.68 0.33 3.59e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs561341 0.714 rs75861674 chr17:30304317 A/G cg00745463 chr17:30367425 LRRC37B -0.67 -6.78 -0.38 7.66e-11 Hip circumference adjusted for BMI; CESC cis rs4481887 0.741 rs6587467 chr1:248550976 T/G cg26353448 chr1:248524236 OR2T4 -0.38 -5.29 -0.31 2.56e-7 Common traits (Other); CESC cis rs6754311 0.731 rs7569057 chr2:136583958 A/C cg07169764 chr2:136633963 MCM6 0.67 8.1 0.45 1.98e-14 Mosquito bite size; CESC cis rs2456568 0.548 rs6483280 chr11:93661592 T/C cg04235223 chr11:93583509 C11orf90 -0.37 -5.13 -0.3 5.55e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs7071206 0.947 rs11002226 chr10:79399656 T/A cg00983440 chr10:79422392 NA -0.68 -8.07 -0.44 2.43e-14 Bone mineral density; CESC cis rs3771570 1.000 rs16843590 chr2:242298228 G/A cg21155796 chr2:242212141 HDLBP 0.59 5.11 0.3 6.19e-7 Prostate cancer; CESC cis rs9811920 0.809 rs902159 chr3:99747445 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.47 7.87 0.44 9.11e-14 Axial length; CESC cis rs6456156 0.586 rs1407315 chr6:167468659 A/G cg23791538 chr6:167370224 RNASET2 -0.5 -6.47 -0.37 4.66e-10 Primary biliary cholangitis; CESC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 11.95 0.59 1.3e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9300255 0.544 rs1716157 chr12:123670473 T/C cg05973401 chr12:123451056 ABCB9 0.49 5.49 0.32 9.51e-8 Neutrophil percentage of white cells; CESC trans rs7980799 0.682 rs10844611 chr12:33603544 T/C cg26384229 chr12:38710491 ALG10B -0.53 -7.65 -0.43 3.76e-13 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs8078723 0.668 rs3859191 chr17:38128714 G/A cg17467752 chr17:38218738 THRA 0.55 7.98 0.44 4.57e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC trans rs73198271 0.653 rs10099808 chr8:8659873 A/G cg23754772 chr18:12253859 CIDEA 0.32 6.04 0.35 5.08e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg19077165 chr18:44547161 KATNAL2 0.47 6.49 0.37 4.22e-10 Personality dimensions; CESC cis rs12200560 0.505 rs211166 chr6:97068598 T/C cg06623918 chr6:96969491 KIAA0776 0.52 6.64 0.38 1.76e-10 Coronary heart disease; CESC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg22920501 chr2:26401640 FAM59B 0.91 10.33 0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs7216064 0.954 rs8079291 chr17:65887622 A/G cg07042672 chr17:66097459 LOC651250 -0.52 -5.4 -0.31 1.5e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11583043 1.000 rs11584222 chr1:101480110 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.52 5.78 0.33 2.1e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.43 5.72 0.33 2.87e-8 Bipolar disorder; CESC cis rs7089973 0.604 rs7923693 chr10:116619566 A/G cg23260525 chr10:116636907 FAM160B1 0.42 8.12 0.45 1.8e-14 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7312933 0.966 rs6582375 chr12:42423185 A/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.42 5.53 0.32 7.51e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg23711669 chr6:146136114 FBXO30 0.97 14.77 0.67 2.05e-36 Lobe attachment (rater-scored or self-reported); CESC trans rs7937682 0.889 rs487985 chr11:111517908 G/A cg18187862 chr3:45730750 SACM1L 0.51 6.47 0.37 4.81e-10 Primary sclerosing cholangitis; CESC cis rs9815354 1.000 rs9855965 chr3:41860508 C/T cg03022575 chr3:42003672 ULK4 0.45 5.06 0.3 7.71e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs10129255 0.536 rs3944157 chr14:107138303 C/T cg23076370 chr14:107095027 NA -0.51 -7.15 -0.4 8.66e-12 Kawasaki disease; CESC cis rs2274273 0.840 rs6573013 chr14:55735873 A/C cg04306507 chr14:55594613 LGALS3 0.29 5.57 0.32 6.21e-8 Protein biomarker; CESC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg02221750 chr19:17393354 ANKLE1 -0.52 -6.38 -0.36 8.01e-10 Systemic lupus erythematosus; CESC cis rs2841277 0.676 rs10438247 chr14:105411781 G/A cg14403583 chr14:105418241 AHNAK2 -0.61 -8.56 -0.47 9.32e-16 Rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09765074 chr10:69634185 NA -0.59 -7.58 -0.42 5.88e-13 Gut microbiome composition (summer); CESC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg11890956 chr21:40555474 PSMG1 -0.92 -14.63 -0.67 6.36e-36 Cognitive function; CESC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg09509183 chr1:209979624 IRF6 0.45 5.93 0.34 9.35e-9 Cleft lip with or without cleft palate; CESC trans rs875971 0.964 rs6945032 chr7:65922486 C/T cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs7666738 0.830 rs890470 chr4:98923435 A/C cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs5769765 1.000 rs2319458 chr22:50236306 G/A cg02269571 chr22:50332266 NA -0.46 -5.92 -0.34 9.84e-9 Schizophrenia; CESC cis rs9902453 0.967 rs12602065 chr17:28482488 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 8.08 0.44 2.37e-14 Coffee consumption (cups per day); CESC cis rs6921919 0.562 rs13198809 chr6:28323702 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 5.59 0.32 5.74e-8 Autism spectrum disorder or schizophrenia; CESC cis rs6088580 0.660 rs6087592 chr20:33114503 A/G cg06115741 chr20:33292138 TP53INP2 0.44 5.5 0.32 8.99e-8 Glomerular filtration rate (creatinine); CESC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg10691866 chr7:65817282 TPST1 0.33 5.47 0.32 1.02e-7 Aortic root size; CESC cis rs3947 0.756 rs1613883 chr8:11699632 T/A cg00262122 chr8:11665843 FDFT1 -0.5 -5.28 -0.31 2.75e-7 Blood protein levels; CESC cis rs11098499 0.691 rs17009144 chr4:120270795 C/T cg09307838 chr4:120376055 NA -0.74 -10.1 -0.53 1.67e-20 Corneal astigmatism; CESC cis rs2439831 0.850 rs10163054 chr15:44047638 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.7 8.06 0.44 2.56e-14 Lung cancer in ever smokers; CESC cis rs6750795 0.542 rs1797388 chr2:232415981 T/G cg19187155 chr2:232395269 NMUR1 0.65 11.47 0.58 5.35e-25 Height; CESC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.42 -0.5 2.37e-18 Alzheimer's disease; CESC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg10691866 chr7:65817282 TPST1 0.34 5.78 0.33 2.13e-8 Aortic root size; CESC cis rs9457247 1.000 rs9457247 chr6:167392174 C/T cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC cis rs941873 0.772 rs7920127 chr10:81122914 T/C cg09469691 chr10:81107165 PPIF 0.54 7.25 0.41 4.69e-12 Height; CESC trans rs73568641 0.583 rs1892360 chr6:154111701 T/C cg08374472 chr16:87445639 ZCCHC14 -0.48 -6.3 -0.36 1.2e-9 Methadone dose in opioid dependence; CESC trans rs748404 0.631 rs7166812 chr15:43644760 T/C cg24053811 chr14:70265306 SLC10A1 0.42 6.03 0.35 5.35e-9 Lung cancer; CESC cis rs9303401 0.646 rs7217845 chr17:57236900 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.56 7.2 0.4 6.32e-12 Cognitive test performance; CESC cis rs7584330 0.737 rs11886117 chr2:238361650 A/T cg14458575 chr2:238380390 NA 0.54 7.55 0.42 7.05e-13 Prostate cancer; CESC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg18016565 chr1:150552671 MCL1 0.34 5.35 0.31 1.93e-7 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27194998 chr19:47217554 PRKD2 -0.47 -6.38 -0.36 7.66e-10 Fibrinogen levels; CESC cis rs17376456 0.877 rs10059230 chr5:93450347 A/G cg21475434 chr5:93447410 FAM172A 0.82 7.56 0.42 6.81e-13 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09845709 chr7:23571490 TRA2A 0.56 6.64 0.38 1.82e-10 Gut microbiome composition (summer); CESC cis rs4851870 1.000 rs4851870 chr2:106437256 C/T cg16077055 chr2:106428750 NCK2 -0.39 -5.1 -0.3 6.56e-7 Addiction; CESC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg11890956 chr21:40555474 PSMG1 1.19 21.95 0.8 1.5e-61 Cognitive function; CESC cis rs10885582 0.809 rs10885579 chr10:116304958 C/T cg17056676 chr10:116301354 ABLIM1 -0.29 -5.3 -0.31 2.4e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs731174 0.802 rs6426030 chr1:38188195 A/G cg12339802 chr1:38156545 C1orf109 -0.58 -5.92 -0.34 9.96e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs4253772 0.591 rs6007748 chr22:46657798 A/G cg24881330 chr22:46731750 TRMU 0.88 9.72 0.51 2.74e-19 LDL cholesterol;Cholesterol, total; CESC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg14393609 chr7:65229607 NA 0.52 6.98 0.39 2.42e-11 Calcium levels; CESC cis rs561341 1.000 rs2470267 chr17:30274132 G/A cg12193833 chr17:30244370 NA -0.61 -6.2 -0.36 2.19e-9 Hip circumference adjusted for BMI; CESC cis rs796364 1.000 rs166845 chr2:200823360 T/A cg23649088 chr2:200775458 C2orf69 0.55 5.33 0.31 2.14e-7 Schizophrenia; CESC cis rs9902453 0.808 rs78154346 chr17:28169493 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.37 0.46 3.33e-15 Coffee consumption (cups per day); CESC cis rs56235845 0.694 rs4976643 chr5:176760227 A/C cg16006841 chr5:176797999 RGS14 0.46 5.62 0.33 4.82e-8 Hemoglobin concentration;Hematocrit; CESC trans rs12339966 0.689 rs2821210 chr9:11680111 G/A cg03904639 chr13:37677730 CSNK1A1L 0.39 5.99 0.35 6.65e-9 Systolic blood pressure; CESC cis rs2777491 0.957 rs919961 chr15:41651721 A/G cg02330683 chr15:41787940 ITPKA 0.42 6.24 0.36 1.7e-9 Ulcerative colitis; CESC cis rs6674176 0.569 rs11210935 chr1:44369444 G/A cg13606994 chr1:44402422 ARTN -0.36 -5.22 -0.31 3.57e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08270031 chr1:180472207 ACBD6 -0.45 -6.43 -0.37 5.92e-10 Gut microbiota (bacterial taxa); CESC cis rs4474465 0.920 rs10751291 chr11:78217687 T/C cg01578073 chr11:78285783 NARS2 -0.46 -5.06 -0.3 7.99e-7 Alzheimer's disease (survival time); CESC cis rs12681288 0.550 rs4410933 chr8:959581 A/G cg04851639 chr8:1020857 NA -0.29 -5.88 -0.34 1.2e-8 Schizophrenia; CESC cis rs4900538 0.963 rs1885708 chr14:102960164 A/G cg18135206 chr14:102964638 TECPR2 0.84 11.4 0.57 9.37e-25 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7044106 0.708 rs2416760 chr9:123374639 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.16 0.63 9.03e-31 Hip circumference adjusted for BMI; CESC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg06221963 chr1:154839813 KCNN3 -0.65 -10.66 -0.55 2.59e-22 Prostate cancer; CESC cis rs1832871 0.672 rs9457361 chr6:158771750 G/A cg07165851 chr6:158734300 TULP4 0.58 6.19 0.36 2.31e-9 Height; CESC cis rs34779708 0.966 rs57081218 chr10:35434608 A/G cg04310649 chr10:35416472 CREM -0.55 -6.64 -0.38 1.72e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs10911232 0.507 rs4652763 chr1:182994084 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg11663144 chr21:46675770 NA -0.5 -7.83 -0.43 1.17e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs17376456 0.877 rs55832164 chr5:93436579 C/T cg25358565 chr5:93447407 FAM172A 1.14 11.29 0.57 2.12e-24 Diabetic retinopathy; CESC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.39 0.37 7.25e-10 Bipolar disorder; CESC cis rs3741151 0.686 rs7114376 chr11:73227361 T/C cg17517138 chr11:73019481 ARHGEF17 0.58 5.16 0.3 4.76e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs698833 0.892 rs698831 chr2:44731117 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.59 0.32 5.61e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs11249608 0.511 rs58827878 chr5:178481936 C/G cg21905437 chr5:178450457 ZNF879 0.51 6.52 0.37 3.48e-10 Pubertal anthropometrics; CESC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.54 7.31 0.41 3.09e-12 Bipolar disorder; CESC cis rs9309473 0.528 rs11898362 chr2:73565293 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.45 -0.37 5.34e-10 Metabolite levels; CESC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg17340268 chr14:105411764 AHNAK2 -0.49 -6.51 -0.37 3.84e-10 Rheumatoid arthritis; CESC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg05535760 chr7:792225 HEATR2 -0.78 -8.24 -0.45 8.16e-15 Cerebrospinal P-tau181p levels; CESC cis rs1801251 0.963 rs13011298 chr2:233612996 A/G cg08000102 chr2:233561755 GIGYF2 0.65 9.33 0.5 4.51e-18 Coronary artery disease; CESC cis rs8031584 1.000 rs35239376 chr15:31290538 A/C cg08109568 chr15:31115862 NA -0.71 -8.86 -0.48 1.22e-16 Huntington's disease progression; CESC cis rs9811920 0.809 rs796976 chr3:99621002 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 7.72 0.43 2.44e-13 Axial length; CESC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg14159672 chr1:205819179 PM20D1 -0.39 -5.13 -0.3 5.51e-7 Parkinson's disease; CESC trans rs875971 0.964 rs11765965 chr7:65842221 A/G cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.66e-9 Aortic root size; CESC cis rs6439153 0.933 rs6799008 chr3:128717387 G/T cg25356066 chr3:128598488 ACAD9 0.54 7.0 0.4 2.1e-11 Pneumococcal bacteremia; CESC cis rs3820928 1.000 rs2163041 chr2:227772480 T/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.74 -0.33 2.55e-8 Pulmonary function; CESC cis rs9611565 0.681 rs5751094 chr22:41803279 C/T cg03806693 chr22:41940476 POLR3H 1.04 12.37 0.61 4.76e-28 Vitiligo; CESC cis rs2882667 0.858 rs11957527 chr5:138404895 T/C cg04439458 chr5:138467593 SIL1 -0.37 -5.84 -0.34 1.53e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1348850 0.914 rs4893823 chr2:178285811 C/T cg22681709 chr2:178499509 PDE11A 0.4 5.9 0.34 1.13e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4973397 0.810 rs12993290 chr2:232279687 G/A cg09339159 chr2:232260559 B3GNT7 0.6 5.95 0.34 8.45e-9 Anti-saccade response; CESC cis rs7100689 0.646 rs9804236 chr10:82135100 T/C cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs664172 1 rs664172 chr15:78862762 G/A cg24631222 chr15:78858424 CHRNA5 0.81 10.41 0.54 1.7e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg11366901 chr6:160182831 ACAT2 0.84 11.06 0.56 1.28e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg11890956 chr21:40555474 PSMG1 -0.67 -9.62 -0.51 5.62e-19 Menarche (age at onset); CESC cis rs17376456 1.000 rs35184505 chr5:93561535 A/G cg21475434 chr5:93447410 FAM172A 0.83 7.06 0.4 1.43e-11 Diabetic retinopathy; CESC cis rs2734839 0.927 rs2734837 chr11:113286829 C/T cg14159747 chr11:113255604 NA 0.3 5.4 0.31 1.52e-7 Information processing speed; CESC cis rs10754283 0.967 rs7519971 chr1:90108743 G/A cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg22535103 chr8:58192502 C8orf71 -0.93 -10.39 -0.54 1.89e-21 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg26314531 chr2:26401878 FAM59B -0.59 -6.64 -0.38 1.79e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.717 rs17226274 chr16:89850170 C/T cg04013166 chr16:89971882 TCF25 0.78 7.26 0.41 4.33e-12 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09969776 chr17:507582 VPS53 -0.63 -7.48 -0.42 1.1e-12 Gut microbiome composition (summer); CESC cis rs6089584 0.566 rs11699442 chr20:60623268 A/G cg24733560 chr20:60626293 TAF4 0.46 6.77 0.38 8.09e-11 Body mass index; CESC trans rs7513165 0.935 rs4951316 chr1:204161490 C/T cg04123578 chr16:4368124 NA -0.36 -6.03 -0.35 5.35e-9 Psychosis proneness (hypomanic personality scale);Psychosis proneness (hypomanic personality scale and perceptual aberration scale);Psychosis proneness (hypomanic personality scale and revised social anhedonia scale);Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale); CESC cis rs7264396 0.563 rs2425079 chr20:34298191 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.7 0.38 1.23e-10 Total cholesterol levels; CESC cis rs12048904 0.964 rs17123467 chr1:101331760 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 6.52 0.37 3.5e-10 Multiple sclerosis; CESC cis rs7949030 0.596 rs11231138 chr11:62316195 C/G cg13298116 chr11:62369859 EML3;MTA2 0.63 9.16 0.49 1.42e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.54 0.54 6.22e-22 Height; CESC cis rs12478296 0.901 rs59477854 chr2:243015490 T/C cg06360820 chr2:242988706 NA -0.78 -9.65 -0.51 4.35e-19 Obesity-related traits; CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg17372223 chr3:52568218 NT5DC2 0.56 9.5 0.5 1.27e-18 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25220428 chr6:19144084 NA -0.55 -6.65 -0.38 1.63e-10 Gut microbiome composition (summer); CESC cis rs6912958 0.559 rs446851 chr6:88043640 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.46 8.01 0.44 3.68e-14 Monocyte percentage of white cells; CESC cis rs11122272 0.735 rs910824 chr1:231498773 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.61 -0.42 4.76e-13 Hemoglobin concentration; CESC cis rs4568518 0.619 rs6946266 chr7:18007588 G/C cg03009463 chr7:17980271 SNX13 0.45 5.96 0.34 7.95e-9 Measles; CESC cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg12826209 chr6:26865740 GUSBL1 0.77 9.25 0.49 7.72e-18 Intelligence (multi-trait analysis); CESC cis rs116095464 0.867 rs10061296 chr5:312253 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.62 5.04 0.3 8.7e-7 Breast cancer; CESC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg18404041 chr3:52824283 ITIH1 -0.4 -6.81 -0.39 6.39e-11 Intelligence (multi-trait analysis); CESC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.44 0.61 2.67e-28 Gut microbiome composition (summer); CESC cis rs4423214 0.959 rs11606611 chr11:71164046 C/G cg05163923 chr11:71159392 DHCR7 0.76 10.16 0.53 1.05e-20 Vitamin D levels; CESC cis rs12145833 0.538 rs10926977 chr1:243411367 T/G cg02356786 chr1:243265016 LOC731275 0.77 6.16 0.35 2.75e-9 Obesity (early onset extreme); CESC cis rs7267979 1.000 rs2258884 chr20:25279539 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg06713675 chr4:122721982 EXOSC9 -0.42 -5.98 -0.34 7.1e-9 Type 2 diabetes; CESC cis rs9908102 0.710 rs7211164 chr17:12917212 C/T cg26162695 chr17:12921313 ELAC2 0.55 5.9 0.34 1.12e-8 Schizophrenia; CESC trans rs561341 1.000 rs55736640 chr17:30333848 G/A cg27661571 chr11:113659931 NA -0.86 -7.61 -0.42 4.78e-13 Hip circumference adjusted for BMI; CESC cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg20135002 chr11:47629003 NA -0.39 -5.03 -0.3 9.2e-7 Subjective well-being; CESC cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.52 0.32 7.98e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg04234412 chr22:24373322 LOC391322 -0.54 -7.66 -0.43 3.43e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs798766 0.953 rs13123646 chr4:1740539 T/C cg07041428 chr4:1763019 NA -0.4 -5.67 -0.33 3.75e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg05313129 chr8:58192883 C8orf71 -0.48 -5.62 -0.33 4.83e-8 Developmental language disorder (linguistic errors); CESC cis rs897984 0.609 rs732172 chr16:31050033 C/T cg02466173 chr16:30829666 NA -0.42 -7.29 -0.41 3.49e-12 Dementia with Lewy bodies; CESC trans rs17607347 0.542 rs8048181 chr16:72687065 C/T cg19883748 chr14:71905595 NA -0.4 -6.01 -0.35 6.14e-9 Intelligence (multi-trait analysis); CESC cis rs59918340 0.728 rs10112337 chr8:142233573 A/G cg16341495 chr8:142228727 SLC45A4 0.42 5.19 0.3 4.24e-7 Immature fraction of reticulocytes; CESC trans rs61931739 0.927 rs1906135 chr12:34038103 C/A cg26384229 chr12:38710491 ALG10B -0.46 -6.16 -0.35 2.75e-9 Morning vs. evening chronotype; CESC cis rs9303401 0.659 rs36093395 chr17:56957357 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.45 0.61 2.57e-28 Cognitive test performance; CESC cis rs9300255 0.602 rs1790095 chr12:123681222 G/A cg19016782 chr12:123741754 C12orf65 -0.44 -6.19 -0.36 2.33e-9 Neutrophil percentage of white cells; CESC cis rs7927592 0.763 rs10896340 chr11:68312645 A/G cg20283391 chr11:68216788 NA 0.43 5.38 0.31 1.67e-7 Total body bone mineral density; CESC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg25767906 chr1:53392781 SCP2 -0.46 -6.03 -0.35 5.48e-9 Monocyte count; CESC cis rs2243480 0.901 rs778693 chr7:65872345 T/G cg12463550 chr7:65579703 CRCP 0.71 5.49 0.32 9.37e-8 Diabetic kidney disease; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg17541715 chr7:1216824 NA -0.38 -5.16 -0.3 4.91e-7 Longevity;Endometriosis; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg06077741 chr3:43121458 C3orf39 0.47 6.03 0.35 5.35e-9 Recombination measurement; CESC cis rs3008870 0.651 rs2815376 chr1:67508531 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.42 5.33 0.31 2.12e-7 Lymphocyte percentage of white cells; CESC trans rs7906315 0.967 rs3814573 chr10:114898093 C/T cg15830682 chr1:6298637 NA -0.49 -6.35 -0.36 9.27e-10 Breast cancer; CESC cis rs1215050 0.791 rs2658477 chr4:98850993 G/A cg05340658 chr4:99064831 C4orf37 -0.5 -6.63 -0.38 1.92e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs12049330 0.673 rs1608916 chr1:110055806 A/T cg05049280 chr1:110155535 GNAT2 0.59 6.46 0.37 5.01e-10 Major depressive disorder; CESC cis rs3733585 0.648 rs13103497 chr4:9979262 A/G cg02734326 chr4:10020555 SLC2A9 0.43 6.1 0.35 3.83e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1005277 0.505 rs7917943 chr10:38195811 T/A cg00409905 chr10:38381863 ZNF37A 0.56 7.82 0.43 1.28e-13 Extrinsic epigenetic age acceleration; CESC cis rs62064224 0.553 rs9915115 chr17:30684858 A/G cg18200150 chr17:30822561 MYO1D 0.39 5.15 0.3 5.14e-7 Schizophrenia; CESC cis rs10905065 0.930 rs10737012 chr10:5746686 G/A cg11519256 chr10:5708881 ASB13 0.43 5.62 0.33 4.93e-8 Menopause (age at onset); CESC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg12963246 chr6:28129442 ZNF389 0.57 7.67 0.43 3.36e-13 Depression; CESC cis rs8114671 0.836 rs62213676 chr20:33612676 T/A cg06115741 chr20:33292138 TP53INP2 -0.44 -5.29 -0.31 2.53e-7 Height; CESC cis rs2637266 0.967 rs4581393 chr10:78376123 A/C cg18941641 chr10:78392320 NA 0.43 8.24 0.45 8.17e-15 Pulmonary function; CESC cis rs9487051 0.676 rs1608044 chr6:109594076 T/C cg01475377 chr6:109611718 NA -0.44 -6.93 -0.39 3.18e-11 Reticulocyte fraction of red cells; CESC cis rs3733585 0.648 rs35954357 chr4:9978758 G/C cg11266682 chr4:10021025 SLC2A9 0.56 10.36 0.54 2.41e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2249625 0.523 rs2463707 chr6:72861732 G/A cg18830697 chr6:72922368 RIMS1 -0.42 -6.22 -0.36 1.92e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs10883723 0.810 rs17782574 chr10:104279394 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.88 -0.34 1.23e-8 Allergic disease (asthma, hay fever or eczema); CESC trans rs17635075 0.590 rs57971645 chr4:167156182 G/A cg17369527 chr13:28366702 GSX1 -0.56 -6.21 -0.36 2.06e-9 Obesity-related traits; CESC cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg21138405 chr5:131827807 IRF1 0.37 5.61 0.33 5.2100000000000003e-08 Breast cancer;Mosquito bite size; CESC cis rs6005807 0.543 rs6005866 chr22:29162940 A/G cg15103426 chr22:29168792 CCDC117 0.5 5.08 0.3 7.15e-7 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18548263 chr11:66383669 RBM14 -0.41 -6.18 -0.35 2.39e-9 Gambling; CESC cis rs7662987 0.517 rs1154405 chr4:100008750 G/A cg12011299 chr4:100065546 ADH4 0.6 6.61 0.38 2.11e-10 Smoking initiation; CESC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg24110177 chr3:50126178 RBM5 0.56 7.58 0.42 5.81e-13 Body mass index; CESC cis rs10208940 0.841 rs6731066 chr2:68796618 A/G cg12452813 chr2:68675892 NA 0.54 5.35 0.31 1.88e-7 Urate levels in lean individuals; CESC trans rs10507274 1.000 rs10507274 chr12:117160976 C/T cg05266345 chr17:16439350 NA 0.71 6.07 0.35 4.47e-9 Neuroticism; CESC cis rs3820068 0.705 rs59502343 chr1:15872617 T/C cg17385448 chr1:15911702 AGMAT 0.36 5.66 0.33 3.96e-8 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15441230 chr15:44069583 ELL3 0.65 7.43 0.42 1.52e-12 Gut microbiome composition (summer); CESC cis rs3768617 0.510 rs10911243 chr1:183075415 G/A ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.05e-34 Fuchs's corneal dystrophy; CESC cis rs9911578 0.967 rs11079354 chr17:56594460 G/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.53 -0.32 7.63e-8 Intelligence (multi-trait analysis); CESC cis rs916888 0.773 rs199451 chr17:44801784 G/A cg17911788 chr17:44343683 NA -0.62 -7.91 -0.44 7.07e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs616402 0.527 rs11584327 chr1:10578791 T/C cg07384165 chr1:10488281 NA -0.57 -8.34 -0.46 4.01e-15 Breast size; CESC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs10885582 0.809 rs11196784 chr10:116305140 A/G cg17056676 chr10:116301354 ABLIM1 -0.28 -5.11 -0.3 6.14e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg18135555 chr8:22132992 PIWIL2 0.24 5.3 0.31 2.47e-7 Hypertriglyceridemia; CESC cis rs6429082 0.689 rs10925965 chr1:235708443 C/A cg26050004 chr1:235667680 B3GALNT2 -0.49 -5.33 -0.31 2.14e-7 Adiposity; CESC cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs8077889 0.956 rs4793026 chr17:41850508 A/G cg26893861 chr17:41843967 DUSP3 0.72 8.58 0.47 8.24e-16 Triglycerides; CESC cis rs367615 0.679 rs4259216 chr5:108841817 A/G cg17395555 chr5:108820864 NA 0.63 11.15 0.57 6.19e-24 Colorectal cancer (SNP x SNP interaction); CESC cis rs6499255 1.000 rs1139178 chr16:69781468 T/C cg15192750 chr16:69999425 NA 0.45 5.52 0.32 8.26e-8 IgE levels; CESC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Parkinson's disease; CESC cis rs7551222 0.752 rs12130686 chr1:204554057 G/C cg20240347 chr1:204465584 NA -0.3 -6.02 -0.35 5.94e-9 Schizophrenia; CESC cis rs7107174 1.000 rs4627115 chr11:78007873 T/G cg02023728 chr11:77925099 USP35 0.5 6.69 0.38 1.33e-10 Testicular germ cell tumor; CESC cis rs3008870 1.000 rs12132068 chr1:67451924 G/T cg02640540 chr1:67518911 SLC35D1 -0.52 -5.59 -0.33 5.5e-8 Lymphocyte percentage of white cells; CESC cis rs2191566 0.691 rs4803673 chr19:44584556 C/T cg20607764 chr19:44506953 ZNF230 -0.42 -5.34 -0.31 2.03e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs1050631 0.592 rs1789547 chr18:33725705 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.52 7.01 0.4 1.96e-11 Esophageal squamous cell cancer (length of survival); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10832168 chr17:61600389 KCNH6 0.59 6.26 0.36 1.52e-9 Gut microbiome composition (summer); CESC cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg04478727 chr12:58166393 METTL1;FAM119B 0.75 9.85 0.52 1.05e-19 Multiple sclerosis; CESC cis rs9303401 0.659 rs34351230 chr17:56782555 C/A cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 5.99 0.35 6.83e-9 Electroencephalogram traits; CESC cis rs17376456 0.877 rs10050465 chr5:93349963 C/A cg21475434 chr5:93447410 FAM172A 0.79 6.98 0.39 2.39e-11 Diabetic retinopathy; CESC cis rs3749237 1.000 rs6804655 chr3:49738945 C/T cg03060546 chr3:49711283 APEH 0.64 7.42 0.41 1.59e-12 Resting heart rate; CESC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg23462726 chr11:62437636 C11orf83;C11orf48 -0.42 -5.41 -0.32 1.37e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2046867 0.818 rs17010184 chr3:72870242 A/T cg25664220 chr3:72788482 NA 0.43 6.34 0.36 9.58e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs2304069 0.954 rs4705409 chr5:149414899 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.9 11.52 0.58 3.74e-25 HIV-1 control; CESC cis rs7216064 1.000 rs62085992 chr17:65923083 T/A cg07042672 chr17:66097459 LOC651250 -0.52 -5.35 -0.31 1.9e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08898442 chr6:88183089 SLC35A1 0.6 7.0 0.4 2.14e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19022476 chr8:145745884 LRRC14 -0.52 -6.17 -0.35 2.54e-9 Gut microbiome composition (summer); CESC cis rs709400 0.643 rs11621777 chr14:104072090 A/G cg12935359 chr14:103987150 CKB -0.47 -6.02 -0.35 5.8e-9 Body mass index; CESC cis rs911555 0.755 rs11620897 chr14:103944861 T/G cg24130564 chr14:104152367 KLC1 -0.5 -6.58 -0.37 2.56e-10 Intelligence (multi-trait analysis); CESC trans rs2623325 0.834 rs73134486 chr3:99129722 T/G cg19595760 chr1:25948511 MAN1C1 -0.48 -6.28 -0.36 1.35e-9 Optic cup area;Vertical cup-disc ratio; CESC cis rs863345 0.564 rs7540999 chr1:158504570 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs7727544 0.636 rs2631365 chr5:131705949 T/C cg07395648 chr5:131743802 NA 0.42 5.49 0.32 9.45e-8 Blood metabolite levels; CESC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg18876405 chr7:65276391 NA -0.53 -7.2 -0.4 6.41e-12 Aortic root size; CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 7.36 0.41 2.29e-12 Bipolar disorder; CESC cis rs11792861 0.962 rs3750452 chr9:111801353 T/C cg13535736 chr9:111863775 C9orf5 -0.5 -6.58 -0.37 2.56e-10 Menarche (age at onset); CESC cis rs8114671 0.967 rs6142324 chr20:33789043 C/T cg06115741 chr20:33292138 TP53INP2 -0.42 -5.11 -0.3 6.06e-7 Height; CESC cis rs1448094 0.817 rs7973694 chr12:86335589 A/G cg02569458 chr12:86230093 RASSF9 0.46 6.43 0.37 5.95e-10 Major depressive disorder; CESC trans rs61931739 0.500 rs11053066 chr12:34185318 G/A cg13010199 chr12:38710504 ALG10B 0.48 5.99 0.35 6.66e-9 Morning vs. evening chronotype; CESC trans rs17762452 1.000 rs2165888 chr17:2886122 A/G cg20455774 chr4:1734371 TACC3 -0.46 -6.03 -0.35 5.56e-9 Lymphocyte counts; CESC cis rs920590 0.758 rs35280191 chr8:19665214 A/C cg01411142 chr8:19674711 INTS10 0.56 6.35 0.36 9.51e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg05347473 chr6:146136440 FBXO30 0.72 9.15 0.49 1.55e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs7070678 0.662 rs3780843 chr10:29818827 C/T cg12329853 chr10:29834266 MIR604;SVIL -0.4 -5.26 -0.31 3.03e-7 Platelet thrombus formation; CESC cis rs72945132 0.882 rs113472486 chr11:70194945 C/G cg00319359 chr11:70116639 PPFIA1 0.72 6.84 0.39 5.42e-11 Coronary artery disease; CESC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg11764359 chr7:65958608 NA 0.77 9.76 0.51 2.03e-19 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21205468 chr1:213031575 LQK1;FLVCR1 0.67 7.46 0.42 1.24e-12 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg11764359 chr7:65958608 NA -0.79 -11.16 -0.57 5.72e-24 Aortic root size; CESC trans rs11264799 0.636 rs6696922 chr1:157491322 G/A cg00040427 chr19:14044197 PODNL1 -0.45 -6.21 -0.36 2.07e-9 IgA nephropathy; CESC cis rs7177699 0.557 rs10083697 chr15:79124039 G/A cg04896959 chr15:78267971 NA 0.32 5.04 0.3 8.74e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg22535103 chr8:58192502 C8orf71 0.95 10.29 0.53 4.02e-21 Developmental language disorder (linguistic errors); CESC cis rs2933343 0.729 rs813945 chr3:128660937 A/G cg11901034 chr3:128598214 ACAD9 -0.36 -5.31 -0.31 2.33e-7 IgG glycosylation; CESC cis rs9287719 0.649 rs10186984 chr2:10734192 C/G cg00105475 chr2:10696890 NA -0.4 -5.53 -0.32 7.86e-8 Prostate cancer; CESC cis rs4243830 0.850 rs11122043 chr1:6580429 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.76 -8.3 -0.45 5.42e-15 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25951811 chr14:96858416 AK7 0.59 6.61 0.38 2.09e-10 Gut microbiome composition (summer); CESC cis rs3126085 0.935 rs34188926 chr1:152293481 A/C cg03465714 chr1:152285911 FLG 0.5 5.71 0.33 2.96e-8 Atopic dermatitis; CESC cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.12 0.3 5.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg11764359 chr7:65958608 NA 0.96 15.41 0.69 1.05e-38 Aortic root size; CESC cis rs67311347 0.544 rs2123998 chr3:40359005 C/G cg09455208 chr3:40491958 NA -0.39 -6.97 -0.39 2.51e-11 Renal cell carcinoma; CESC cis rs9549367 0.577 rs3024711 chr13:113813268 A/G cg00898013 chr13:113819073 PROZ -0.5 -6.26 -0.36 1.55e-9 Platelet distribution width; CESC cis rs116095464 0.558 rs10052012 chr5:231908 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.43 0.32 1.3e-7 Breast cancer; CESC cis rs7503807 1.000 rs12939613 chr17:78588202 A/G cg09596252 chr17:78655493 RPTOR 0.45 6.42 0.37 6.33e-10 Obesity; CESC cis rs3820928 0.845 rs4234065 chr2:227882006 C/T cg05526886 chr2:227700861 RHBDD1 -0.43 -5.48 -0.32 9.75e-8 Pulmonary function; CESC cis rs16854884 0.657 rs13086088 chr3:143723942 G/A cg06585982 chr3:143692056 C3orf58 0.51 6.73 0.38 1.02e-10 Economic and political preferences (feminism/equality); CESC cis rs2519796 0.531 rs2519106 chr9:136807283 C/A cg13751417 chr9:136814406 VAV2 -0.43 -5.73 -0.33 2.71e-8 Hematocrit;Hemoglobin concentration; CESC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs116095464 0.558 rs6872854 chr5:209038 G/T cg10591111 chr5:226296 SDHA -0.49 -6.21 -0.36 2.04e-9 Breast cancer; CESC cis rs9487051 0.773 rs351749 chr6:109533353 A/T cg01475377 chr6:109611718 NA -0.44 -6.76 -0.38 8.56e-11 Reticulocyte fraction of red cells; CESC cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg14416269 chr4:6271139 WFS1 0.47 7.85 0.43 1.03e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs17021463 0.844 rs17311008 chr4:95274653 A/G cg11021082 chr4:95130006 SMARCAD1 0.53 7.71 0.43 2.53e-13 Testicular germ cell tumor; CESC trans rs116095464 0.614 rs78905930 chr5:246560 G/A cg00938859 chr5:1591904 SDHAP3 0.68 7.4 0.41 1.81e-12 Breast cancer; CESC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.12 0.53 1.49e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2425143 1.000 rs11700256 chr20:34372941 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.11 -0.4 1.05e-11 Blood protein levels; CESC cis rs3892630 0.824 rs35700505 chr19:33325006 C/T cg13157960 chr19:33183277 NUDT19 0.54 5.17 0.3 4.52e-7 Red blood cell traits; CESC cis rs1348850 0.958 rs4893941 chr2:178269531 A/T cg22681709 chr2:178499509 PDE11A -0.43 -6.18 -0.35 2.44e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs853679 0.599 rs149990 chr6:27998258 G/A cg18032046 chr6:28092343 ZSCAN16 -0.7 -5.6 -0.33 5.38e-8 Depression; CESC cis rs854765 0.583 rs62064158 chr17:17826935 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.18 0.45 1.22e-14 Total body bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26069066 chr20:44044698 PIGT -0.42 -6.5 -0.37 3.87e-10 Gambling; CESC trans rs61869271 0.871 rs6585310 chr10:116732726 G/A cg17463145 chr7:79084011 MAGI2 0.31 6.24 0.36 1.72e-9 Tonsillectomy; CESC cis rs34779708 0.931 rs35997236 chr10:35376690 C/T cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 12.55 0.61 1.13e-28 Platelet count; CESC cis rs9908102 0.637 rs8078508 chr17:12910523 G/A cg26162695 chr17:12921313 ELAC2 0.52 5.71 0.33 3.04e-8 Schizophrenia; CESC trans rs11098499 0.722 rs1814814 chr4:120258124 C/G cg25214090 chr10:38739885 LOC399744 0.63 9.07 0.49 2.67e-17 Corneal astigmatism; CESC trans rs2727020 0.656 rs7925524 chr11:49437542 G/A cg15704280 chr7:45808275 SEPT13 -0.8 -10.4 -0.54 1.81e-21 Coronary artery disease; CESC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg24562669 chr7:97807699 LMTK2 0.53 7.91 0.44 7.11e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg18402987 chr7:1209562 NA 0.75 7.58 0.42 5.97e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg20503657 chr10:835505 NA 0.76 7.51 0.42 8.89e-13 Eosinophil percentage of granulocytes; CESC trans rs10463316 0.894 rs6579864 chr5:150762181 G/A cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs933688 1.000 rs12655973 chr5:90736537 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 13.74 0.64 8.47e-33 Smoking behavior; CESC cis rs9487051 0.714 rs7774390 chr6:109602461 C/G cg12927641 chr6:109611667 NA 0.36 5.39 0.31 1.59e-7 Reticulocyte fraction of red cells; CESC cis rs6915183 0.967 rs4504454 chr6:166706424 G/A cg14022523 chr6:166756177 SFT2D1 0.54 7.18 0.4 6.82e-12 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04876072 chr3:48594239 PFKFB4 0.56 6.6 0.38 2.27e-10 Gut microbiome composition (summer); CESC trans rs877282 0.898 rs12358513 chr10:757571 A/G cg22713356 chr15:30763199 NA 1.06 9.18 0.49 1.24e-17 Uric acid levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12506373 chr2:27440548 CAD 0.5 6.81 0.39 6.48e-11 Systemic lupus erythematosus; CESC cis rs17253792 0.822 rs75509578 chr14:56133493 G/A cg01858014 chr14:56050164 KTN1 -0.86 -7.2 -0.4 6.37e-12 Putamen volume; CESC cis rs2315504 0.605 rs2469816 chr17:39005954 C/T cg05063374 chr17:38953512 KRT28 0.37 5.06 0.3 7.97e-7 Height; CESC cis rs7851660 0.809 rs1561961 chr9:100667599 C/T cg13688889 chr9:100608707 NA -0.62 -8.72 -0.47 3.08e-16 Strep throat; CESC cis rs113835537 0.529 rs116867234 chr11:66209024 C/T cg24851651 chr11:66362959 CCS 0.53 6.31 0.36 1.19e-9 Airway imaging phenotypes; CESC trans rs9325144 0.671 rs35817541 chr12:38975001 T/C cg23762105 chr12:34175262 ALG10 0.48 6.41 0.37 6.48e-10 Morning vs. evening chronotype; CESC cis rs6674176 0.628 rs4660758 chr1:44424879 A/C cg13606994 chr1:44402422 ARTN -0.37 -5.57 -0.32 6.41e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11636702 chr4:11370466 MIR572 -0.56 -6.95 -0.39 2.9e-11 Gut microbiome composition (summer); CESC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.76e-12 Tonsillectomy; CESC cis rs35110281 0.811 rs9980185 chr21:45057905 A/G cg21573476 chr21:45109991 RRP1B -0.49 -6.59 -0.38 2.32e-10 Mean corpuscular volume; CESC cis rs892961 0.932 rs11658267 chr17:75411884 C/T cg05865280 chr17:75406074 SEPT9 -0.6 -12.57 -0.61 9.64e-29 Airflow obstruction; CESC cis rs6662572 0.737 rs10890356 chr1:46317924 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.04 -0.3 8.65e-7 Blood protein levels; CESC cis rs7149242 1.000 rs7149242 chr14:101159416 G/T cg18089426 chr14:101175970 NA 0.35 5.67 0.33 3.79e-8 Platelet count; CESC cis rs7584330 0.554 rs77194105 chr2:238436463 T/C cg14458575 chr2:238380390 NA 0.73 6.61 0.38 2.09e-10 Prostate cancer; CESC trans rs7837860 0.588 rs7011035 chr8:89299708 T/G cg04391754 chr17:18022714 MYO15A 0.53 6.14 0.35 2.98e-9 Autism spectrum disorder or schizophrenia; CESC cis rs10463316 0.894 rs4099168 chr5:150766467 A/G cg03212797 chr5:150827313 SLC36A1 -0.47 -6.2 -0.36 2.17e-9 Metabolite levels (Pyroglutamine); CESC cis rs763121 0.925 rs4821815 chr22:39105707 G/A cg14440974 chr22:39074834 NA -0.36 -5.23 -0.31 3.41e-7 Menopause (age at onset); CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg01238044 chr22:24384105 GSTT1 -0.68 -8.96 -0.48 5.89e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04811502 chr14:21979673 METTL3 -0.44 -6.15 -0.35 2.87e-9 Asthma; CESC cis rs10206020 0.921 rs72776302 chr2:1571383 G/A cg12573674 chr2:1569213 NA -0.47 -5.35 -0.31 1.93e-7 IgG glycosylation; CESC cis rs6964587 1.000 rs926192 chr7:91671853 C/A cg17063962 chr7:91808500 NA 0.56 7.79 0.43 1.53e-13 Breast cancer; CESC cis rs34779708 0.931 rs4934533 chr10:35359619 A/G cg04310649 chr10:35416472 CREM -0.53 -6.43 -0.37 5.94e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs9910055 0.529 rs228757 chr17:42164885 G/C cg19774624 chr17:42201019 HDAC5 0.53 7.1 0.4 1.17e-11 Total body bone mineral density; CESC cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg01181863 chr3:195395398 SDHAP2 -0.47 -5.53 -0.32 7.83e-8 Pancreatic cancer; CESC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg24675658 chr1:53192096 ZYG11B -0.54 -6.68 -0.38 1.41e-10 Monocyte count; CESC cis rs1957429 0.614 rs7144637 chr14:65349709 A/G cg23373153 chr14:65346875 NA -0.9 -6.61 -0.38 2.11e-10 Pediatric areal bone mineral density (radius); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01249072 chr7:66147992 NA -0.54 -6.66 -0.38 1.6e-10 Gut microbiome composition (summer); CESC cis rs7208859 0.673 rs11652370 chr17:29097223 G/A cg19761014 chr17:28927070 LRRC37B2 0.69 6.76 0.38 8.6e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11867934 0.532 rs4399589 chr17:17114586 A/G cg20098446 chr17:17120238 FLCN 0.35 5.41 0.32 1.43e-7 Diabetic retinopathy; CESC cis rs595982 0.527 rs56021835 chr19:49369989 G/A cg15549821 chr19:49342101 PLEKHA4 -0.68 -7.26 -0.41 4.3e-12 Red cell distribution width; CESC cis rs3008870 1.000 rs2985825 chr1:67412822 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.04 14.57 0.67 9.76e-36 Lymphocyte percentage of white cells; CESC cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg09165964 chr15:75287851 SCAMP5 0.79 9.41 0.5 2.58e-18 Blood trace element (Zn levels); CESC cis rs10752881 0.967 rs4652758 chr1:182975100 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 13.33 0.63 2.34e-31 Colorectal cancer; CESC cis rs7914558 1.000 rs8139 chr10:104848123 G/A cg04362960 chr10:104952993 NT5C2 0.48 6.3 0.36 1.22e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9581857 0.579 rs76614377 chr13:27974251 A/T cg01674679 chr13:27998804 GTF3A -0.7 -5.54 -0.32 7.13e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00243897 chr12:122326549 PSMD9 -0.45 -6.16 -0.35 2.68e-9 Fibrinogen levels; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg19536664 chr17:6899085 ALOX12 0.4 9.0 0.48 4.55e-17 Tonsillectomy; CESC cis rs11122272 0.766 rs2790871 chr1:231543555 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -7.97 -0.44 4.66e-14 Hemoglobin concentration; CESC cis rs9303401 0.538 rs2240259 chr17:56458129 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.95 10.93 0.56 3.46e-23 Cognitive test performance; CESC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg11890956 chr21:40555474 PSMG1 1.14 18.64 0.75 3.94e-50 Cognitive function; CESC cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.1 0.3 6.52e-7 Hip circumference adjusted for BMI; CESC trans rs4596713 0.508 rs4076287 chr9:71755333 A/G cg16512924 chr15:28394682 HERC2 0.49 6.3 0.36 1.25e-9 Headache; CESC cis rs5753618 0.583 rs5753639 chr22:31870400 A/G cg02404636 chr22:31891804 SFI1 -0.43 -6.01 -0.35 5.96e-9 Colorectal cancer; CESC cis rs35570576 0.585 rs7216806 chr17:77538517 C/T cg05749138 chr17:77536956 NA -0.36 -5.08 -0.3 7.19e-7 Photic sneeze reflex; CESC cis rs7208859 0.673 rs73277978 chr17:29191449 A/G cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 0.606 rs28625338 chr4:99076996 A/G cg17366294 chr4:99064904 C4orf37 0.45 6.03 0.35 5.39e-9 Colonoscopy-negative controls vs population controls; CESC cis rs763014 0.931 rs10903017 chr16:627920 T/C cg07343612 chr16:622815 PIGQ -0.58 -8.47 -0.46 1.72e-15 Height; CESC cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg24450063 chr1:156163899 SLC25A44 1.09 23.41 0.82 1.83e-66 Testicular germ cell tumor; CESC cis rs3733585 0.699 rs6449158 chr4:9960459 T/C cg00071950 chr4:10020882 SLC2A9 -0.73 -11.83 -0.59 3.28e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1957429 0.901 rs7141985 chr14:65345670 C/T cg23373153 chr14:65346875 NA 1.1 11.51 0.58 4.02e-25 Pediatric areal bone mineral density (radius); CESC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.11 -22.58 -0.81 1.05e-63 Prudent dietary pattern; CESC cis rs6921919 0.583 rs9468355 chr6:28341877 A/G cg21251018 chr6:28226885 NKAPL 0.31 5.35 0.31 1.93e-7 Autism spectrum disorder or schizophrenia; CESC cis rs6540559 0.543 rs672819 chr1:210436404 T/A cg21951975 chr1:209979733 IRF6 0.48 6.03 0.35 5.59e-9 Cleft lip with or without cleft palate; CESC cis rs17655565 1.000 rs2276399 chr12:52705269 G/A cg08257133 chr12:52711352 KRT83 0.51 6.34 0.36 9.61e-10 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg07936489 chr17:37558343 FBXL20 -0.82 -12.22 -0.6 1.6e-27 Glomerular filtration rate (creatinine); CESC cis rs902774 0.554 rs4919749 chr12:53358034 C/T cg25025879 chr12:53359317 NA -0.53 -7.01 -0.4 1.99e-11 Prostate cancer; CESC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg02269571 chr22:50332266 NA -0.56 -6.92 -0.39 3.35e-11 Schizophrenia; CESC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg05332525 chr7:65337924 VKORC1L1 0.49 6.13 0.35 3.2e-9 Aortic root size; CESC cis rs67311347 1.000 rs951560 chr3:40463471 A/G cg09455208 chr3:40491958 NA 0.44 7.57 0.42 6.1e-13 Renal cell carcinoma; CESC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg02592271 chr2:27665507 KRTCAP3 -0.3 -6.24 -0.36 1.77e-9 Total body bone mineral density; CESC cis rs3087591 1.000 rs2905800 chr17:29531980 A/G cg24425628 chr17:29625626 OMG;NF1 0.44 5.5 0.32 9.13e-8 Hip circumference; CESC cis rs920590 0.684 rs59259846 chr8:19669468 C/G cg17834443 chr8:19674713 INTS10 0.59 6.53 0.37 3.35e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg18758796 chr5:131593413 PDLIM4 0.46 6.17 0.35 2.55e-9 Acylcarnitine levels; CESC cis rs9911578 0.967 rs11079368 chr17:57086473 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.06 -0.3 7.78e-7 Intelligence (multi-trait analysis); CESC cis rs710216 0.912 rs11537640 chr1:43424519 T/G cg22176566 chr1:43424700 SLC2A1 0.48 5.34 0.31 1.96e-7 Red cell distribution width; CESC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg24733560 chr20:60626293 TAF4 0.42 5.62 0.33 4.76e-8 Body mass index; CESC cis rs12477438 0.765 rs10193039 chr2:99692373 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -9.04 -0.49 3.32e-17 Chronic sinus infection; CESC cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg21918786 chr6:109611834 NA -0.4 -6.14 -0.35 3.02e-9 Reticulocyte fraction of red cells; CESC cis rs698833 0.852 rs2241870 chr2:44549204 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.58 7.33 0.41 2.8e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs938554 0.779 rs11735831 chr4:9951591 G/A cg00071950 chr4:10020882 SLC2A9 -0.5 -5.82 -0.34 1.7e-8 Blood metabolite levels; CESC cis rs9467711 0.720 rs9348716 chr6:26375658 G/A cg14345882 chr6:26364793 BTN3A2 0.61 6.06 0.35 4.73e-9 Autism spectrum disorder or schizophrenia; CESC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg04317338 chr11:64019027 PLCB3 0.88 9.12 0.49 1.91e-17 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22333016 chr4:54244258 FIP1L1 0.61 7.08 0.4 1.27e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20708961 chr19:22235256 ZNF257 -0.5 -6.24 -0.36 1.68e-9 Gut microbiome composition (summer); CESC trans rs9858542 0.953 rs6446272 chr3:49463287 G/A cg21659725 chr3:3221576 CRBN -0.55 -6.52 -0.37 3.63e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6740322 0.843 rs6727237 chr2:43562000 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.58 -6.39 -0.37 7.6e-10 Coronary artery disease; CESC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg24101359 chr6:42928495 GNMT 0.57 8.29 0.45 5.87e-15 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg23758822 chr17:41437982 NA 1.02 15.6 0.69 2.35e-39 Menopause (age at onset); CESC cis rs2742417 0.603 rs2742370 chr3:45782098 T/C cg04837898 chr3:45731254 SACM1L -0.45 -5.8 -0.34 1.86e-8 Response to anti-depressant treatment in major depressive disorder; CESC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg18252515 chr7:66147081 NA 0.45 5.9 0.34 1.09e-8 Aortic root size; CESC cis rs2380220 0.640 rs9320386 chr6:95994955 T/C cg04719120 chr6:96025338 MANEA 0.55 5.4 0.32 1.45e-7 Behavioural disinhibition (generation interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02063551 chr15:75315956 PPCDC 0.58 6.14 0.35 2.96e-9 Gut microbiome composition (summer); CESC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg02951883 chr7:2050386 MAD1L1 -0.45 -5.78 -0.33 2.06e-8 Bipolar disorder and schizophrenia; CESC cis rs8141529 0.732 rs11556025 chr22:29168755 T/C cg15103426 chr22:29168792 CCDC117 0.7 9.76 0.51 1.98e-19 Lymphocyte counts; CESC cis rs644148 0.836 rs2686770 chr19:44998773 A/G cg15540054 chr19:45004280 ZNF180 -0.62 -6.7 -0.38 1.23e-10 Personality dimensions; CESC trans rs9858542 0.953 rs11713474 chr3:49611457 A/G cg21659725 chr3:3221576 CRBN -0.52 -6.4 -0.37 6.83e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9911578 0.967 rs6416932 chr17:57148991 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.4 5.16 0.3 4.9e-7 Intelligence (multi-trait analysis); CESC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg22638593 chr5:131593259 PDLIM4 0.4 5.33 0.31 2.11e-7 Breast cancer; CESC cis rs9394931 1.000 rs9394931 chr6:42873245 C/T cg21280719 chr6:42927975 GNMT 0.27 5.87 0.34 1.33e-8 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CESC cis rs3820068 0.608 rs6668919 chr1:16049893 A/G cg18133145 chr1:16060689 PLEKHM2 0.41 5.17 0.3 4.54e-7 Systolic blood pressure; CESC cis rs9902453 0.769 rs7210288 chr17:28243473 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.2 0.45 1.05e-14 Coffee consumption (cups per day); CESC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg06873352 chr17:61820015 STRADA 0.72 12.76 0.62 2.21e-29 Prudent dietary pattern; CESC cis rs722599 0.683 rs8008475 chr14:75291900 C/T cg11812906 chr14:75593930 NEK9 0.45 5.53 0.32 7.6e-8 IgG glycosylation; CESC trans rs7307889 0.793 rs73047640 chr12:6008290 C/T cg18407955 chr7:158110685 PTPRN2 -0.73 -6.28 -0.36 1.38e-9 Obesity-related traits; CESC cis rs137699 0.687 rs4821887 chr22:39756985 C/T cg05872129 chr22:39784769 NA -0.63 -7.43 -0.42 1.51e-12 IgG glycosylation; CESC cis rs6430585 0.583 rs2304370 chr2:136561735 G/A cg07169764 chr2:136633963 MCM6 1.21 16.81 0.72 1.18e-43 Corneal structure; CESC cis rs6674176 0.696 rs4448553 chr1:44411589 A/G cg12908607 chr1:44402522 ARTN -0.47 -6.92 -0.39 3.43e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9486719 0.843 rs2103539 chr6:96844342 T/A cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07450219 chr17:78428858 NA -0.49 -6.08 -0.35 4.09e-9 Ulcerative colitis; CESC trans rs6089829 0.925 rs11086152 chr20:61664656 T/C cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs60843830 1.000 rs62114548 chr2:274672 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 8.28 0.45 6.1e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs11997175 0.546 rs11775414 chr8:33615826 A/G ch.8.33884649F chr8:33765107 NA 0.57 7.35 0.41 2.5e-12 Body mass index; CESC cis rs4891159 0.548 rs2554830 chr18:74127702 A/G cg24786174 chr18:74118243 ZNF516 0.84 15.89 0.7 2.23e-40 Longevity; CESC cis rs13242816 1.000 rs62471202 chr7:116112562 G/A cg04696780 chr7:116139425 CAV2 -0.58 -5.2 -0.3 4.08e-7 P wave duration; CESC cis rs8014204 0.901 rs4899536 chr14:75316614 A/G cg11812906 chr14:75593930 NEK9 -0.44 -5.48 -0.32 9.97e-8 Caffeine consumption; CESC trans rs4349753 0.640 rs72804497 chr5:144083142 C/A cg22407458 chr6:35109121 TCP11 0.5 6.31 0.36 1.18e-9 Photic sneeze reflex; CESC cis rs13253111 1.000 rs62500888 chr8:28061823 A/G cg26534493 chr8:28060551 NA 0.61 10.67 0.55 2.46e-22 Childhood body mass index; CESC cis rs7100689 0.646 rs10887808 chr10:82137367 G/A cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs4727027 0.901 rs1534198 chr7:148772323 T/C cg23158103 chr7:148848205 ZNF398 -0.41 -6.55 -0.37 2.9e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs12478296 1.000 rs12478296 chr2:243048760 A/G cg06360820 chr2:242988706 NA 0.66 7.68 0.43 3.06e-13 Obesity-related traits; CESC cis rs11677370 0.561 rs11687254 chr2:3830906 C/T cg17052675 chr2:3827356 NA -0.48 -6.22 -0.36 1.96e-9 Type 2 diabetes; CESC cis rs9611565 0.500 rs10775759 chr22:42088158 T/C cg06634786 chr22:41940651 POLR3H 0.6 6.18 0.35 2.39e-9 Vitiligo; CESC cis rs7607369 0.536 rs12694443 chr2:219664977 G/T cg02176678 chr2:219576539 TTLL4 -0.36 -6.44 -0.37 5.62e-10 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs910316 0.737 rs175080 chr14:75513828 G/A cg08847533 chr14:75593920 NEK9 -0.89 -15.41 -0.69 1.09e-38 Height; CESC cis rs9479482 1.000 rs9479482 chr6:150358012 T/C cg03788504 chr6:150331562 NA -0.38 -7.22 -0.41 5.37e-12 Alopecia areata; CESC cis rs62158211 1.000 rs1807282 chr2:114110036 A/T cg17784749 chr2:114082611 LOC440839 0.72 7.82 0.43 1.22e-13 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CESC cis rs2439831 1.000 rs550239 chr15:43720197 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.82 12.0 0.59 8.48e-27 Lung cancer in ever smokers; CESC cis rs9303401 0.659 rs17822908 chr17:56801778 T/C cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC cis rs7116495 1.000 rs675185 chr11:71775572 T/G cg10381502 chr11:71823885 C11orf51 -0.67 -5.66 -0.33 3.92e-8 Severe influenza A (H1N1) infection; CESC cis rs4594175 0.962 rs4254242 chr14:51599184 A/C cg23942311 chr14:51606299 NA 0.37 5.4 0.31 1.48e-7 Cancer; CESC cis rs4728302 0.838 rs6974143 chr7:133603550 G/A cg10665199 chr7:133106180 EXOC4 0.4 5.56 0.32 6.62e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs262150 0.579 rs4909110 chr7:158787332 C/T cg23096020 chr7:158799433 NA 0.47 5.23 0.31 3.49e-7 Facial morphology (factor 20); CESC cis rs1152591 1.000 rs1152591 chr14:64680848 A/G cg21174375 chr14:64681225 SYNE2 0.47 6.27 0.36 1.45e-9 Atrial fibrillation; CESC cis rs17095355 0.901 rs10884919 chr10:111757791 G/A cg00817464 chr10:111662876 XPNPEP1 -0.52 -5.99 -0.35 6.73e-9 Biliary atresia; CESC cis rs2415984 0.600 rs2415958 chr14:46806262 C/G cg14871534 chr14:47121158 RPL10L -0.34 -5.06 -0.3 7.86e-7 Number of children ever born; CESC cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg05283184 chr6:79620031 NA -0.44 -6.78 -0.38 7.67e-11 Intelligence (multi-trait analysis); CESC cis rs8180040 0.764 rs62246375 chr3:47014464 G/A cg27129171 chr3:47204927 SETD2 -0.66 -9.33 -0.5 4.26e-18 Colorectal cancer; CESC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg04369109 chr6:150039330 LATS1 0.4 5.63 0.33 4.51e-8 Lung cancer; CESC cis rs2797160 0.935 rs1739379 chr6:126012593 T/C cg05901451 chr6:126070800 HEY2 0.46 6.56 0.37 2.81e-10 Endometrial cancer; CESC cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg03433033 chr1:76189801 ACADM 0.54 6.29 0.36 1.32e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg24562669 chr7:97807699 LMTK2 0.53 7.91 0.44 7e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs6142102 0.625 rs6142051 chr20:32533018 T/C cg08999081 chr20:33150536 PIGU 0.34 5.14 0.3 5.46e-7 Skin pigmentation; CESC cis rs425277 1.000 rs74877653 chr1:2065949 C/T cg04315214 chr1:2043799 PRKCZ -0.42 -5.91 -0.34 1.04e-8 Height; CESC trans rs801193 0.761 rs2659888 chr7:66230171 T/G cg14393609 chr7:65229607 NA 0.47 6.38 0.36 7.64e-10 Aortic root size; CESC cis rs8068544 0.748 rs75881902 chr17:40156612 C/A cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.94 -8.43 -0.46 2.27e-15 Reticulocyte fraction of red cells;Reticulocyte count; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg04917373 chr1:231489252 C1orf124 0.4 6.08 0.35 4.14e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1975974 1.000 rs67946006 chr17:21723940 T/C cg18423549 chr17:21743878 NA -0.51 -7.12 -0.4 1.04e-11 Psoriasis; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg16338035 chr3:143691269 C3orf58 -0.43 -6.12 -0.35 3.42e-9 Vertical cup-disc ratio; CESC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.94 14.0 0.65 1.02e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg00074818 chr8:8560427 CLDN23 0.38 5.46 0.32 1.1e-7 Obesity-related traits; CESC cis rs7542091 0.704 rs1108628 chr1:210041150 A/G cg22029157 chr1:209979665 IRF6 0.49 7.58 0.42 5.79e-13 Monobrow; CESC cis rs7246657 0.943 rs12709813 chr19:37844983 G/A cg23950597 chr19:37808831 NA -0.55 -6.09 -0.35 3.96e-9 Coronary artery calcification; CESC cis rs12479064 0.671 rs62155807 chr2:100076579 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.59 -6.89 -0.39 4.07e-11 Chronic sinus infection; CESC cis rs2637266 1.000 rs2637267 chr10:78331803 A/G cg18941641 chr10:78392320 NA 0.41 7.47 0.42 1.18e-12 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07235652 chr12:109531354 ALKBH2 0.55 6.35 0.36 9.56e-10 Gut microbiome composition (summer); CESC cis rs989128 0.600 rs2240218 chr17:48630580 A/T cg24438145 chr17:48624694 SPATA20 0.45 5.31 0.31 2.36e-7 Type 2 diabetes; CESC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg05564831 chr3:52568323 NT5DC2 0.44 6.89 0.39 4.16e-11 Intelligence (multi-trait analysis); CESC cis rs8114671 0.804 rs6060139 chr20:33566499 T/C cg07148914 chr20:33460835 GGT7 0.43 5.53 0.32 7.59e-8 Height; CESC cis rs12477438 0.520 rs4402818 chr2:99717608 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 15.54 0.69 3.79e-39 Chronic sinus infection; CESC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg22823121 chr1:150693482 HORMAD1 0.45 6.35 0.36 9.55e-10 Melanoma; CESC cis rs116095464 0.558 rs6555058 chr5:226376 C/T cg10591111 chr5:226296 SDHA 0.49 5.94 0.34 9.13e-9 Breast cancer; CESC trans rs763361 1.000 rs1790947 chr18:67527760 A/C cg09273779 chr9:35605990 TESK1 0.44 6.05 0.35 5e-9 Type 1 diabetes; CESC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg07507251 chr3:52567010 NT5DC2 0.41 7.24 0.41 4.75e-12 Bipolar disorder; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg06440065 chr19:30206617 C19orf12 -0.53 -7.22 -0.41 5.67e-12 Thyroid stimulating hormone; CESC cis rs9309473 1.000 rs6755217 chr2:73641285 C/T cg20560298 chr2:73613845 ALMS1 -0.55 -7.12 -0.4 1.02e-11 Metabolite levels; CESC cis rs3806843 1.000 rs11167609 chr5:140200426 T/G cg26395211 chr5:140044315 WDR55 -0.41 -5.13 -0.3 5.72e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2952156 0.876 rs2313171 chr17:37833842 T/C cg07936489 chr17:37558343 FBXL20 -0.61 -8.09 -0.44 2.2e-14 Asthma; CESC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg11764359 chr7:65958608 NA 0.71 9.39 0.5 2.85e-18 Aortic root size; CESC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg16325326 chr1:53192061 ZYG11B 0.55 7.96 0.44 5e-14 Monocyte count; CESC cis rs13242816 1.000 rs13247987 chr7:116113344 A/C cg04696780 chr7:116139425 CAV2 -0.58 -5.2 -0.3 4.08e-7 P wave duration; CESC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg18876405 chr7:65276391 NA -0.51 -5.96 -0.34 8.21e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26476595 chr16:2284284 E4F1 -0.56 -6.59 -0.38 2.32e-10 Gut microbiome composition (summer); CESC cis rs8062405 1.000 rs7498555 chr16:28893571 T/C cg05966235 chr16:28915196 ATP2A1 0.34 5.05 0.3 8.17e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11039798 0.588 rs10838970 chr11:48606267 G/T cg15704280 chr7:45808275 SEPT13 0.61 6.29 0.36 1.32e-9 Axial length; CESC trans rs17132261 0.661 rs80166325 chr5:109666675 C/T cg14311597 chr17:2652531 MIR1253 -0.51 -6.06 -0.35 4.64e-9 Cardiac structure and function;Left ventricle wall thickness; CESC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.66 9.08 0.49 2.51e-17 Menopause (age at onset); CESC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.53 -0.42 7.92e-13 Gut microbiome composition (summer); CESC cis rs10754283 0.967 rs4658130 chr1:90113447 G/C cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs208520 0.874 rs208456 chr6:66907942 A/G cg07460842 chr6:66804631 NA -0.87 -10.33 -0.54 3.12e-21 Exhaled nitric oxide output; CESC cis rs9611565 0.592 rs5751101 chr22:41828111 C/T cg17376030 chr22:41985996 PMM1 -0.76 -8.01 -0.44 3.59e-14 Vitiligo; CESC cis rs4950928 0.823 rs2486065 chr1:203167871 A/G cg14085262 chr1:203155938 CHI3L1 -0.52 -5.68 -0.33 3.51e-8 YKL-40 levels; CESC cis rs4888262 0.545 rs7184754 chr16:74667864 C/T cg01733217 chr16:74700730 RFWD3 0.92 12.63 0.61 6.22e-29 Testicular germ cell tumor; CESC cis rs13223928 0.651 rs4722435 chr7:3152962 C/T cg19214707 chr7:3157722 NA 0.44 5.99 0.35 6.93e-9 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs763121 0.819 rs138700 chr22:39129999 A/G cg14440974 chr22:39074834 NA -0.4 -5.61 -0.33 5.06e-8 Menopause (age at onset); CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg06062125 chr4:76598767 G3BP2 -0.54 -6.42 -0.37 6.35e-10 Lung cancer in ever smokers; CESC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7680126 0.596 rs4637402 chr4:10045430 C/T cg11266682 chr4:10021025 SLC2A9 0.53 7.0 0.39 2.14e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1465370 0.692 rs2402996 chr7:130017003 C/T cg04743876 chr7:130013617 NA 0.31 5.89 0.34 1.18e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs9814567 0.806 rs55835132 chr3:134325256 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.38 -5.06 -0.3 7.86e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7914558 1.000 rs7920251 chr10:104950197 C/T cg04362960 chr10:104952993 NT5C2 0.47 6.29 0.36 1.33e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg11764359 chr7:65958608 NA -0.78 -11.17 -0.57 5.37e-24 Aortic root size; CESC cis rs854765 0.583 rs8070128 chr17:17804725 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.53 -7.38 -0.41 2.04e-12 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07065803 chr11:45921557 MAPK8IP1 0.52 6.0 0.35 6.38e-9 Gut microbiome composition (summer); CESC cis rs3820928 1.000 rs4673173 chr2:227769493 A/C cg05526886 chr2:227700861 RHBDD1 -0.44 -5.63 -0.33 4.63e-8 Pulmonary function; CESC trans rs13098911 0.540 rs71615438 chr3:46039868 A/G cg10236987 chr1:228114221 WNT9A 0.66 6.54 0.37 3.11e-10 Celiac disease; CESC cis rs9611565 0.694 rs5758324 chr22:41787950 G/T cg03806693 chr22:41940476 POLR3H -0.79 -10.09 -0.53 1.81e-20 Vitiligo; CESC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg12963246 chr6:28129442 ZNF389 0.58 7.86 0.43 9.67e-14 Depression; CESC cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.48 -6.46 -0.37 5.03e-10 Personality dimensions; CESC cis rs796364 0.616 rs2103094 chr2:200687954 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.55 5.06 0.3 7.93e-7 Schizophrenia; CESC cis rs3749237 0.555 rs7637665 chr3:49552295 T/C cg06212747 chr3:49208901 KLHDC8B 0.47 6.3 0.36 1.21e-9 Resting heart rate; CESC cis rs7666738 0.830 rs7694889 chr4:98855596 T/C cg05340658 chr4:99064831 C4orf37 0.74 10.7 0.55 1.97e-22 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.45 0.37 5.14e-10 Bipolar disorder; CESC cis rs72781680 1.000 rs56339200 chr2:24188194 C/A cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.56e-8 Lymphocyte counts; CESC cis rs7216064 1.000 rs6504543 chr17:65837659 T/C cg12091567 chr17:66097778 LOC651250 -0.81 -9.3 -0.5 5.41e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg26304593 chr6:42947056 PEX6 -0.43 -5.65 -0.33 4.24e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2050392 0.760 rs10826797 chr10:30690376 A/C cg18806716 chr10:30721971 MAP3K8 -0.59 -8.82 -0.48 1.53e-16 Inflammatory bowel disease; CESC cis rs17539620 0.624 rs62432735 chr6:154834055 T/C cg20019720 chr6:154832845 CNKSR3 0.47 6.03 0.35 5.62e-9 Lipoprotein (a) levels; CESC trans rs57221529 0.766 rs17563576 chr5:560476 A/G cg25482853 chr8:67687455 SGK3 1.09 11.54 0.58 3.07e-25 Lung disease severity in cystic fibrosis; CESC trans rs2749592 0.550 rs7081464 chr10:37883937 C/T cg12057190 chr19:54976211 LENG9;CDC42EP5 -0.44 -6.35 -0.36 9.39e-10 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26623551 chr16:14165028 MKL2 -0.51 -6.28 -0.36 1.38e-9 Ulcerative colitis; CESC cis rs10088262 0.540 rs6988602 chr8:124788502 C/T cg20713898 chr8:124780851 FAM91A1 0.58 7.11 0.4 1.09e-11 Pancreatic cancer; CESC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs2012796 0.956 rs6574646 chr14:81819809 A/G cg02996355 chr14:81879375 NA 0.51 6.04 0.35 5.31e-9 Night sleep phenotypes; CESC cis rs6741892 0.536 rs6761563 chr2:38891406 A/T cg05604112 chr2:38893237 GALM -0.55 -7.19 -0.4 6.65e-12 5-HTT brain serotonin transporter levels; CESC cis rs10851478 0.872 rs10851479 chr15:49909741 C/T cg08060515 chr15:49448048 GALK2;COPS2 0.43 5.26 0.31 3e-7 Oral cavity cancer; CESC cis rs1401999 0.714 rs1533683 chr3:183635488 C/T cg01324343 chr3:183735012 ABCC5 0.53 10.88 0.56 4.8e-23 Anterior chamber depth; CESC cis rs9549260 0.755 rs2721071 chr13:41144507 G/A cg21288729 chr13:41239152 FOXO1 0.67 8.54 0.46 1.07e-15 Red blood cell count; CESC cis rs72829446 0.530 rs3853820 chr17:7396781 A/T cg02795151 chr17:7402630 POLR2A 0.58 6.04 0.35 5.08e-9 Androgen levels; CESC cis rs7216064 1.000 rs60432293 chr17:65860407 T/C cg07042672 chr17:66097459 LOC651250 -0.57 -6.66 -0.38 1.55e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs5753618 0.539 rs1034588 chr22:31616301 A/G cg13145458 chr22:31556086 RNF185 0.48 5.41 0.32 1.43e-7 Colorectal cancer; CESC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.11 -0.3 6.15e-7 Breast cancer; CESC cis rs3857536 0.776 rs4710316 chr6:66935097 T/A cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs7481584 0.581 rs399565 chr11:3061780 C/T cg25174290 chr11:3078921 CARS -0.51 -7.13 -0.4 9.46e-12 Calcium levels; CESC cis rs2115630 0.691 rs2292462 chr15:85200754 G/T cg12501888 chr15:85177176 SCAND2 -0.51 -6.8 -0.39 6.83e-11 P wave terminal force; CESC cis rs11112613 0.653 rs59504344 chr12:105950837 C/T cg03607813 chr12:105948248 NA 0.58 7.21 0.4 6.01e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs7267979 1.000 rs884613 chr20:25288505 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.13 -0.7 3.07e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg07092213 chr7:1199455 ZFAND2A -0.49 -5.3 -0.31 2.38e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.18 0.3 4.42e-7 Bipolar disorder; CESC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg07507251 chr3:52567010 NT5DC2 0.42 7.37 0.41 2.11e-12 Bipolar disorder; CESC cis rs2228479 0.681 rs7199685 chr16:89959805 G/C cg06558623 chr16:89946397 TCF25 0.55 5.52 0.32 7.88e-8 Skin colour saturation; CESC cis rs4555082 0.874 rs28625632 chr14:105748849 G/T cg06808227 chr14:105710500 BRF1 -0.55 -6.17 -0.35 2.56e-9 Mean platelet volume;Platelet distribution width; CESC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg24829409 chr8:58192753 C8orf71 -0.75 -9.93 -0.52 5.93e-20 Developmental language disorder (linguistic errors); CESC cis rs5758511 0.596 rs55644935 chr22:42666069 A/G cg00645731 chr22:42541494 CYP2D7P1 0.57 8.62 0.47 6.07e-16 Birth weight; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg23358871 chr17:78121069 EIF4A3 0.43 6.0 0.35 6.35e-9 Systemic lupus erythematosus; CESC cis rs12295403 0.964 rs61886869 chr11:18688508 C/T cg09887367 chr11:18690185 NA -0.39 -5.5 -0.32 8.85e-8 Ovarian reserve; CESC cis rs7071206 0.947 rs4979905 chr10:79416367 C/T cg07817648 chr10:79422355 NA -0.87 -11.19 -0.57 4.47e-24 Bone mineral density; CESC cis rs11696501 0.688 rs6094192 chr20:44297796 G/A cg11783356 chr20:44313418 WFDC10B -0.34 -5.29 -0.31 2.59e-7 Brain structure; CESC cis rs2204008 0.837 rs11180482 chr12:38235950 G/A cg13010199 chr12:38710504 ALG10B 0.49 6.1 0.35 3.78e-9 Bladder cancer; CESC cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg17971929 chr21:40555470 PSMG1 0.59 7.61 0.42 4.85e-13 Cognitive function; CESC cis rs3960554 0.808 rs868555 chr7:75697418 G/A cg17325771 chr7:75508891 RHBDD2 -0.35 -5.33 -0.31 2.07e-7 Eotaxin levels; CESC cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4704187 0.687 rs10051040 chr5:74501976 G/C cg03227963 chr5:74354835 NA 0.29 5.27 0.31 2.77e-7 Response to amphetamines; CESC cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.74 10.68 0.55 2.25e-22 Hip circumference adjusted for BMI; CESC trans rs7246760 0.867 rs8102257 chr19:9830795 C/T cg02900749 chr2:68251473 NA -0.82 -7.4 -0.41 1.8e-12 Pursuit maintenance gain; CESC cis rs9309473 0.519 rs2421545 chr2:73639476 T/C cg20560298 chr2:73613845 ALMS1 0.49 7.05 0.4 1.52e-11 Metabolite levels; CESC trans rs61931739 0.500 rs11053246 chr12:34516620 C/T cg13010199 chr12:38710504 ALG10B 0.5 6.42 0.37 6.3e-10 Morning vs. evening chronotype; CESC cis rs6933660 0.800 rs3800273 chr6:151759035 G/C cg10883421 chr6:151773342 RMND1;C6orf211 0.87 14.43 0.66 3.05e-35 Menarche (age at onset); CESC cis rs748404 0.723 rs512431 chr15:43541939 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.52 -8.11 -0.45 1.86e-14 Lung cancer; CESC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg10792982 chr14:105748885 BRF1 0.43 5.76 0.33 2.33e-8 Mean platelet volume;Platelet distribution width; CESC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg22903471 chr2:27725779 GCKR -0.5 -7.16 -0.4 7.71e-12 Total body bone mineral density; CESC cis rs17253792 0.822 rs10083431 chr14:56068348 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.98 0.34 7.23e-9 Putamen volume; CESC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg02951883 chr7:2050386 MAD1L1 -0.41 -5.36 -0.31 1.82e-7 Bipolar disorder and schizophrenia; CESC cis rs710865 0.519 rs10753518 chr1:19483593 T/C cg13387374 chr1:19411106 UBR4 0.52 6.96 0.39 2.65e-11 Brain structure; CESC cis rs7666738 0.830 rs7672901 chr4:98938781 C/T cg03467027 chr4:99064603 C4orf37 0.48 5.96 0.34 7.94e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7914558 0.966 rs7096269 chr10:104736721 A/G cg15744005 chr10:104629667 AS3MT -0.33 -5.23 -0.31 3.48e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4974559 0.947 rs10018627 chr4:1356358 G/A cg02980000 chr4:1222292 CTBP1 0.73 6.78 0.38 7.65e-11 Systolic blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24663397 chr14:55034535 SAMD4A -0.48 -6.25 -0.36 1.6e-9 Fibrinogen levels; CESC cis rs9910055 0.529 rs228765 chr17:42186422 C/T cg19774624 chr17:42201019 HDAC5 0.58 7.84 0.43 1.07e-13 Total body bone mineral density; CESC cis rs59918340 0.728 rs35257077 chr8:142235049 C/T cg16341495 chr8:142228727 SLC45A4 0.42 5.06 0.3 7.7e-7 Immature fraction of reticulocytes; CESC cis rs155076 0.938 rs536209 chr13:21847714 C/T cg11317459 chr13:21872234 NA -1.05 -11.58 -0.58 2.37e-25 White matter hyperintensity burden; CESC cis rs7772486 0.754 rs9386133 chr6:146141213 A/G cg23711669 chr6:146136114 FBXO30 0.87 12.78 0.62 1.84e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs2979489 0.891 rs2915594 chr8:30401367 T/C cg26383811 chr8:30366931 RBPMS -0.79 -9.91 -0.52 6.89e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg17143192 chr8:8559678 CLDN23 0.72 8.18 0.45 1.19e-14 Obesity-related traits; CESC cis rs72781680 0.612 rs33913065 chr2:24344060 T/G cg08917208 chr2:24149416 ATAD2B 0.57 5.52 0.32 8.27e-8 Lymphocyte counts; CESC cis rs9297145 0.673 rs12531875 chr7:98724730 C/T cg05967295 chr7:98741636 SMURF1 0.91 9.02 0.48 3.9e-17 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs12477438 0.871 rs13396584 chr2:99611768 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.67 8.15 0.45 1.45e-14 Chronic sinus infection; CESC cis rs1707322 0.682 rs3014241 chr1:46087879 A/G cg06784218 chr1:46089804 CCDC17 -0.4 -6.94 -0.39 3.07e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs62432291 0.764 rs436743 chr6:159655102 A/G cg14500486 chr6:159655392 FNDC1 -0.62 -6.21 -0.36 2.04e-9 Joint mobility (Beighton score); CESC cis rs6445797 0.603 rs11706624 chr3:56584341 T/C cg13792233 chr3:56591045 CCDC66 0.39 5.15 0.3 4.97e-7 Gastritis; CESC cis rs7605827 0.930 rs918157 chr2:15657729 G/A cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.65e-10 Educational attainment (years of education); CESC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg13918804 chr1:2043761 PRKCZ 0.27 5.18 0.3 4.31e-7 Height; CESC trans rs11638815 0.954 rs11635442 chr15:83328542 C/G cg25333056 chr10:135107159 TUBGCP2 -0.46 -6.0 -0.35 6.59e-9 Lipoprotein-associated phospholipase A2 activity change in response to statin therapy; CESC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg04772025 chr11:68637568 NA 0.49 5.62 0.33 4.92e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs372883 0.532 rs425989 chr21:30715275 T/C cg24692254 chr21:30365293 RNF160 -0.48 -6.43 -0.37 6.02e-10 Pancreatic cancer; CESC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.93 13.79 0.65 5.71e-33 Prudent dietary pattern; CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg16132339 chr22:24313637 DDTL;DDT 0.39 5.92 0.34 9.84e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs67311347 0.911 rs58282210 chr3:40417943 C/T cg09455208 chr3:40491958 NA 0.52 8.88 0.48 1.01e-16 Renal cell carcinoma; CESC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.58 0.37 2.5e-10 Bipolar disorder; CESC trans rs2727020 0.595 rs10839286 chr11:49497063 C/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.98 -0.72 2.94e-44 Coronary artery disease; CESC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.06 0.3 7.92e-7 Menopause (age at onset); CESC cis rs6964587 0.626 rs6979235 chr7:91511776 T/C cg17063962 chr7:91808500 NA -0.45 -6.36 -0.36 9.03e-10 Breast cancer; CESC cis rs1577917 1.000 rs1911553 chr6:86630892 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -5.53 -0.32 7.75e-8 Response to antipsychotic treatment; CESC cis rs8072100 0.935 rs78551919 chr17:45626002 A/C cg08085267 chr17:45401833 C17orf57 0.46 6.12 0.35 3.37e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs8014204 0.839 rs6574197 chr14:75331487 A/G cg26191576 chr14:75389716 RPS6KL1 0.37 5.29 0.31 2.58e-7 Caffeine consumption; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg13910983 chr1:28241279 RPA2 -0.5 -7.19 -0.4 6.73e-12 Asthma; CESC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs8018808 1.000 rs12101153 chr14:77863091 A/C cg20045696 chr14:77926864 AHSA1 -0.43 -5.81 -0.34 1.82e-8 Myeloid white cell count; CESC cis rs1728785 0.688 rs7203363 chr16:68587692 T/A cg02972257 chr16:68554789 NA -0.59 -6.69 -0.38 1.29e-10 Ulcerative colitis; CESC cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg21248554 chr2:27665150 KRTCAP3 -0.37 -7.42 -0.41 1.64e-12 Total body bone mineral density; CESC cis rs55728055 0.661 rs62237765 chr22:31956981 A/G cg01338084 chr22:32026380 PISD 1.29 8.76 0.47 2.44e-16 Age-related hearing impairment; CESC cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg02297831 chr4:17616191 MED28 0.62 7.91 0.44 7.23e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs8062405 0.573 rs7140 chr16:28995757 C/A cg05966235 chr16:28915196 ATP2A1 -0.35 -5.04 -0.3 8.5e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs12530845 0.524 rs7795267 chr7:135308455 C/G cg23117316 chr7:135346802 PL-5283 -0.52 -5.9 -0.34 1.1e-8 Red blood cell traits; CESC cis rs910316 0.726 rs175040 chr14:75469555 A/G cg08847533 chr14:75593920 NEK9 -0.9 -15.79 -0.7 4.7e-40 Height; CESC cis rs9479482 1.000 rs9479405 chr6:150338065 G/A cg03788504 chr6:150331562 NA -0.36 -7.03 -0.4 1.8e-11 Alopecia areata; CESC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg06221963 chr1:154839813 KCNN3 0.67 11.39 0.57 9.73e-25 Prostate cancer; CESC cis rs116095464 0.558 rs10475136 chr5:232796 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.41 0.32 1.43e-7 Breast cancer; CESC cis rs708547 0.874 rs1315006 chr4:57858193 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.6 -6.01 -0.35 6.09e-9 Response to bleomycin (chromatid breaks); CESC cis rs72634258 0.519 rs36040967 chr1:7931804 A/G cg00042356 chr1:8021962 PARK7 0.59 5.88 0.34 1.22e-8 Inflammatory bowel disease; CESC cis rs17826219 0.500 rs28452421 chr17:29083980 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Body mass index; CESC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg04369109 chr6:150039330 LATS1 -0.4 -5.51 -0.32 8.53e-8 Lung cancer; CESC cis rs4803468 1.000 rs2241710 chr19:41912092 G/C cg14132834 chr19:41945861 ATP5SL -0.66 -8.12 -0.45 1.78e-14 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20962746 chr11:118436826 C11orf60 -0.59 -7.43 -0.42 1.48e-12 Gut microbiome composition (summer); CESC cis rs11166927 1.000 rs10435690 chr8:140802093 C/T cg16909799 chr8:140841666 TRAPPC9 0.55 8.27 0.45 6.75e-15 Pediatric non-alcoholic fatty liver disease activity score; CESC trans rs11098499 0.866 rs12510451 chr4:120289143 C/T cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12169852 chr17:57231726 SKA2;PRR11 -0.43 -6.09 -0.35 3.88e-9 Asthma; CESC cis rs1322639 0.614 rs6900964 chr6:169566763 A/G cg03254818 chr6:169586852 NA 0.54 5.71 0.33 3.09e-8 Pulse pressure; CESC cis rs7605827 0.930 rs12692263 chr2:15539206 G/A cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg23161317 chr6:28129485 ZNF389 0.44 5.72 0.33 2.86e-8 Parkinson's disease; CESC cis rs2070433 0.539 rs1008549 chr21:47959698 C/T cg12379764 chr21:47803548 PCNT 0.63 8.31 0.45 5.16e-15 Lymphocyte counts; CESC cis rs7845219 0.544 rs4735331 chr8:95917958 C/T cg13393036 chr8:95962371 TP53INP1 -0.42 -8.03 -0.44 3.25e-14 Type 2 diabetes; CESC cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg25019033 chr10:957182 NA -0.62 -6.92 -0.39 3.49e-11 Eosinophil percentage of granulocytes; CESC cis rs1355223 0.525 rs7129517 chr11:34872236 A/C cg11622362 chr11:34938112 PDHX;APIP 0.45 5.26 0.31 2.99e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg11890956 chr21:40555474 PSMG1 -0.93 -14.9 -0.68 6.67e-37 Cognitive function; CESC cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.1e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg24549020 chr5:56110836 MAP3K1 0.68 7.64 0.43 3.9e-13 Initial pursuit acceleration; CESC cis rs6736093 0.966 rs11692445 chr2:112704033 T/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.3 -0.31 2.49e-7 Coronary artery disease; CESC trans rs7618501 0.633 rs6792892 chr3:49995518 T/C cg21659725 chr3:3221576 CRBN 0.55 7.6 0.42 5.29e-13 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg23281280 chr6:28129359 ZNF389 0.59 8.16 0.45 1.34e-14 Depression; CESC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg09699651 chr6:150184138 LRP11 0.41 5.13 0.3 5.62e-7 Lung cancer; CESC cis rs2479106 0.854 rs4391495 chr9:126462986 G/C cg16191174 chr9:126692580 DENND1A 0.47 6.39 0.37 7.36e-10 Polycystic ovary syndrome; CESC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg03264133 chr6:25882463 NA -0.44 -6.42 -0.37 6.15e-10 Intelligence (multi-trait analysis); CESC cis rs9549260 0.632 rs7323267 chr13:41204015 A/G cg21288729 chr13:41239152 FOXO1 0.55 5.33 0.31 2.1e-7 Red blood cell count; CESC cis rs6674176 1.000 rs6674176 chr1:44379957 G/A cg13606994 chr1:44402422 ARTN -0.4 -5.88 -0.34 1.2e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg17724175 chr1:150552817 MCL1 0.45 7.33 0.41 2.84e-12 Tonsillectomy; CESC cis rs72781680 0.898 rs72782136 chr2:24047344 A/G cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs7666738 0.830 rs62318503 chr4:98935479 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.528 rs56258075 chr2:24104256 C/G cg20701182 chr2:24300061 SF3B14 0.64 5.82 0.34 1.73e-8 Lymphocyte counts; CESC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.86 -8.59 -0.47 7.5e-16 Mean platelet volume; CESC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.38 5.04 0.3 8.73e-7 Menopause (age at onset); CESC cis rs4595586 0.545 rs4768526 chr12:39402898 A/G cg26384229 chr12:38710491 ALG10B 0.63 8.83 0.48 1.5e-16 Morning vs. evening chronotype; CESC cis rs4604732 0.631 rs75320597 chr1:247626751 T/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs62229266 0.804 rs62230788 chr21:37380337 A/T cg08632701 chr21:37451849 NA -0.38 -5.07 -0.3 7.4e-7 Mitral valve prolapse; CESC cis rs6831352 0.918 rs2851247 chr4:100046091 C/G cg12011299 chr4:100065546 ADH4 -0.6 -6.46 -0.37 5.05e-10 Alcohol dependence; CESC cis rs9486719 1.000 rs12205655 chr6:96891733 T/A cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg19717773 chr7:2847554 GNA12 -0.53 -8.48 -0.46 1.56e-15 Height; CESC cis rs8044868 0.586 rs7200854 chr16:72083318 G/A cg16558253 chr16:72132732 DHX38 -0.4 -6.32 -0.36 1.12e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg14393609 chr7:65229607 NA 0.52 6.97 0.39 2.47e-11 Aortic root size; CESC cis rs34117943 1 rs34117943 chr16:68819642 C/CT cg02972257 chr16:68554789 NA 0.45 5.22 0.31 3.62e-7 Mean corpuscular volume; CESC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg27165867 chr14:105738592 BRF1 -0.51 -5.56 -0.32 6.63e-8 Mean platelet volume;Platelet distribution width; CESC cis rs9583531 0.843 rs7999702 chr13:111382264 A/C cg24331049 chr13:111365604 ING1 -0.75 -7.87 -0.44 8.93e-14 Coronary artery disease; CESC cis rs7998202 0.561 rs442098 chr13:113353032 C/A cg02820901 chr13:113351484 ATP11A 0.64 5.91 0.34 1.07e-8 Glycated hemoglobin levels; CESC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.2 0.4 6.13e-12 Tonsillectomy; CESC cis rs858239 0.536 rs6961109 chr7:23252413 C/T cg23682824 chr7:23144976 KLHL7 0.45 5.89 0.34 1.14e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg17211192 chr8:82754475 SNX16 -0.65 -7.74 -0.43 2.1e-13 Diastolic blood pressure; CESC cis rs929596 0.606 rs7604115 chr2:234658116 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.59 -7.32 -0.41 2.95e-12 Total bilirubin levels in HIV-1 infection; CESC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg05564831 chr3:52568323 NT5DC2 0.45 6.97 0.39 2.55e-11 Bipolar disorder; CESC cis rs950169 0.887 rs62029593 chr15:84955180 A/G cg17507749 chr15:85114479 UBE2QP1 0.59 6.54 0.37 3.11e-10 Schizophrenia; CESC trans rs7819412 0.668 rs4841507 chr8:11046394 C/G cg15556689 chr8:8085844 FLJ10661 -0.47 -6.0 -0.35 6.4e-9 Triglycerides; CESC cis rs668210 0.793 rs522553 chr11:65771669 T/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.68 7.46 0.42 1.26e-12 Cerebrospinal fluid biomarker levels; CESC cis rs3091242 0.933 rs7541095 chr1:25761291 T/C cg02931644 chr1:25747376 RHCE 0.39 6.56 0.37 2.87e-10 Erythrocyte sedimentation rate; CESC trans rs12310956 0.532 rs7955514 chr12:33978737 G/A cg26384229 chr12:38710491 ALG10B 0.58 8.12 0.45 1.8e-14 Morning vs. evening chronotype; CESC cis rs9436116 1 rs9436116 chr1:150454724 G/T cg09579323 chr1:150459698 TARS2 0.45 5.68 0.33 3.55e-8 Morning vs. evening chronotype; CESC trans rs10489896 0.541 rs6682410 chr1:234570685 G/A cg10395685 chr11:86085715 CCDC81 -0.42 -6.13 -0.35 3.19e-9 Cognitive test performance; CESC cis rs11190604 1.000 rs10883501 chr10:102238326 A/G cg07080220 chr10:102295463 HIF1AN 0.56 5.59 0.32 5.61e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs936229 0.656 rs12898397 chr15:75130093 T/C cg09165964 chr15:75287851 SCAMP5 0.47 6.38 0.36 7.92e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18231159 chr7:99214508 ZNF498 0.61 7.03 0.4 1.74e-11 Gut microbiome composition (summer); CESC cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg24308560 chr3:49941425 MST1R 0.6 8.61 0.47 6.53e-16 Intelligence (multi-trait analysis); CESC cis rs2439831 1.000 rs2601014 chr15:43756013 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.8 9.89 0.52 7.9e-20 Lung cancer in ever smokers; CESC cis rs9858542 0.951 rs1800668 chr3:49395757 G/A cg03060546 chr3:49711283 APEH -0.52 -5.96 -0.34 7.89e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.44 5.77 0.33 2.25e-8 Lymphocyte counts; CESC cis rs6032067 0.852 rs6032064 chr20:43854827 A/G cg10761708 chr20:43804764 PI3 0.5 6.15 0.35 2.83e-9 Blood protein levels; CESC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg15145296 chr3:125709740 NA -0.48 -5.25 -0.31 3.05e-7 Blood pressure (smoking interaction); CESC cis rs1665050 0.534 rs35124643 chr15:59242001 A/G cg05156742 chr15:59063176 FAM63B 0.49 6.19 0.36 2.33e-9 Atopic dermatitis; CESC cis rs11608355 0.545 rs2302706 chr12:109894028 A/G cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs9837602 1.000 rs9864437 chr3:99764754 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.56 0.42 6.43e-13 Breast cancer; CESC cis rs7818345 0.967 rs4554480 chr8:19284072 G/A cg11303988 chr8:19266685 CSGALNACT1 0.35 6.42 0.37 6.41e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs3733585 0.648 rs13103497 chr4:9979262 A/G cg00071950 chr4:10020882 SLC2A9 0.69 10.86 0.56 5.56e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6964587 0.773 rs12536421 chr7:92008220 A/G cg17063962 chr7:91808500 NA 0.57 7.4 0.41 1.77e-12 Breast cancer; CESC cis rs7116495 0.609 rs4944243 chr11:71674354 T/C cg07596299 chr11:71824057 C11orf51 -0.83 -5.36 -0.31 1.8e-7 Severe influenza A (H1N1) infection; CESC cis rs7605827 0.897 rs34191114 chr2:15670691 C/A cg19274914 chr2:15703543 NA 0.36 6.45 0.37 5.21e-10 Educational attainment (years of education); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15260365 chr11:67771606 UNC93B1 -0.46 -6.72 -0.38 1.1e-10 Fibrinogen levels; CESC cis rs1218582 0.600 rs72702224 chr1:154911689 G/A cg06221963 chr1:154839813 KCNN3 -0.6 -9.5 -0.5 1.29e-18 Prostate cancer; CESC cis rs2228479 0.681 rs62052184 chr16:89967217 T/C cg06558623 chr16:89946397 TCF25 0.55 5.28 0.31 2.71e-7 Skin colour saturation; CESC cis rs7818688 0.614 rs11783589 chr8:95845964 G/A cg16049864 chr8:95962084 TP53INP1 0.52 5.48 0.32 9.71e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4253772 0.591 rs6007795 chr22:46686792 C/G cg09491104 chr22:46646882 C22orf40 -0.63 -9.37 -0.5 3.4e-18 LDL cholesterol;Cholesterol, total; CESC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg05564831 chr3:52568323 NT5DC2 0.47 7.48 0.42 1.08e-12 Bipolar disorder; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg25135259 chr10:115614956 NHLRC2;DCLRE1A -0.48 -6.11 -0.35 3.56e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs561341 0.943 rs508566 chr17:30289861 G/C cg12193833 chr17:30244370 NA -0.75 -6.79 -0.38 7.44e-11 Hip circumference adjusted for BMI; CESC cis rs6540559 0.673 rs4556361 chr1:210019654 C/G cg23283495 chr1:209979779 IRF6 -0.44 -5.2 -0.3 4.05e-7 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20021244 chr5:139944115 APBB3;SLC35A4 -0.63 -7.3 -0.41 3.36e-12 Gut microbiome composition (summer); CESC cis rs1707322 0.721 rs4564187 chr1:46166861 G/C cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs76917914 0.820 rs7034147 chr9:100821691 T/G cg03040243 chr9:100819229 NANS 0.48 5.38 0.31 1.65e-7 Immature fraction of reticulocytes; CESC cis rs11677416 1.000 rs2856836 chr2:113532083 A/G cg27083787 chr2:113543245 IL1A 0.59 7.34 0.41 2.58e-12 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs9926296 0.656 rs4522419 chr16:89853307 T/C cg04287289 chr16:89883240 FANCA 0.63 7.98 0.44 4.52e-14 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26488985 chr16:89584852 SPG7 -0.58 -7.02 -0.4 1.87e-11 Gut microbiome composition (summer); CESC cis rs782590 0.818 rs2627765 chr2:55883317 G/T cg18811423 chr2:55921094 PNPT1 0.77 12.26 0.6 1.09e-27 Metabolic syndrome; CESC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg23978390 chr7:1156363 C7orf50 0.62 6.1 0.35 3.83e-9 Bronchopulmonary dysplasia; CESC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg13393036 chr8:95962371 TP53INP1 -0.48 -10.36 -0.54 2.51e-21 Type 2 diabetes; CESC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg01988459 chr11:68622903 NA 0.47 6.76 0.38 8.55e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs116988415 0.539 rs11623956 chr14:65270391 G/A cg25083366 chr14:65239357 SPTB 0.71 5.1 0.3 6.62e-7 Daytime sleep phenotypes; CESC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg03806693 chr22:41940476 POLR3H -1.21 -15.42 -0.69 9.91e-39 Vitiligo; CESC cis rs4664304 0.597 rs979129 chr2:160840151 T/C cg03641300 chr2:160917029 PLA2R1 -0.44 -6.07 -0.35 4.38e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg24818145 chr4:99064322 C4orf37 0.39 5.04 0.3 8.74e-7 Colonoscopy-negative controls vs population controls; CESC cis rs936229 0.861 rs12441505 chr15:75107311 A/C cg14664628 chr15:75095509 CSK -1.01 -16.09 -0.7 4.25e-41 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07944278 chr6:35699425 LOC285847 -0.49 -6.29 -0.36 1.3e-9 Ulcerative colitis; CESC cis rs10089 0.951 rs736969 chr5:127466347 G/C cg19767477 chr5:127420684 SLC12A2 -0.39 -5.23 -0.31 3.44e-7 Ileal carcinoids; CESC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg06138931 chr13:21896616 NA 0.47 5.94 0.34 8.88e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4423214 0.959 rs11606033 chr11:71154204 A/G cg24826892 chr11:71159390 DHCR7 0.49 5.78 0.33 2.04e-8 Vitamin D levels; CESC cis rs5743618 0.537 rs10017482 chr4:38765335 A/C cg02016764 chr4:38805732 TLR1 -0.34 -5.21 -0.3 3.84e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs25645 0.823 rs12453334 chr17:38153473 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.6 8.89 0.48 9.75e-17 Myeloid white cell count; CESC cis rs1943345 0.519 rs11233504 chr11:82886525 A/G cg07047830 chr11:82868014 PCF11 0.59 8.21 0.45 9.95e-15 Obesity-related traits; CESC cis rs72766638 0.848 rs11789898 chr9:136925663 A/C cg13789015 chr9:136890014 NCRNA00094 -0.46 -5.1 -0.3 6.35e-7 Mosquito bite size; CESC cis rs28830936 1.000 rs11629485 chr15:41904569 C/T cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.36 -5.09 -0.3 6.84e-7 Diastolic blood pressure; CESC cis rs3824867 0.920 rs80241400 chr11:47453828 T/C cg20307385 chr11:47447363 PSMC3 -0.49 -5.87 -0.34 1.27e-8 Mean corpuscular hemoglobin; CESC cis rs6831352 1.000 rs6532798 chr4:100054827 C/T cg21548116 chr4:100009993 ADH5 0.48 5.09 0.3 6.72e-7 Alcohol dependence; CESC cis rs2191566 0.691 rs55771992 chr19:44588278 G/T cg20607764 chr19:44506953 ZNF230 -0.4 -5.31 -0.31 2.28e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs6582630 0.519 rs11519914 chr12:38287014 A/G cg26384229 chr12:38710491 ALG10B 0.64 9.47 0.5 1.66e-18 Drug-induced liver injury (flucloxacillin); CESC cis rs854765 0.583 rs66531105 chr17:17809001 C/T cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.94e-9 Total body bone mineral density; CESC cis rs2730245 0.959 rs2527201 chr7:158738611 G/T cg24397884 chr7:158709396 WDR60 -0.89 -13.66 -0.64 1.65e-32 Height; CESC cis rs9303401 0.659 rs61291849 chr17:56909867 T/C cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.45 0.61 2.57e-28 Cognitive test performance; CESC cis rs11048434 0.698 rs1805745 chr12:9065226 A/T cg23795048 chr12:9217529 LOC144571 0.36 5.7 0.33 3.24e-8 Sjögren's syndrome; CESC cis rs9929218 0.501 rs12448999 chr16:68815549 T/A cg02972257 chr16:68554789 NA -0.43 -5.38 -0.31 1.68e-7 Colorectal cancer; CESC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg11644478 chr21:40555479 PSMG1 -0.57 -7.75 -0.43 1.95e-13 Menarche (age at onset); CESC cis rs863345 0.604 rs12059669 chr1:158501480 T/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs9287719 0.967 rs7605461 chr2:10738134 G/A cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs11098499 0.955 rs35434465 chr4:120169378 C/G cg09307838 chr4:120376055 NA 0.86 11.34 0.57 1.5e-24 Corneal astigmatism; CESC cis rs4975616 0.869 rs455433 chr5:1336243 A/G cg07493874 chr5:1342172 CLPTM1L -0.41 -7.85 -0.43 1.02e-13 Lung cancer; CESC cis rs4950928 0.887 rs7556099 chr1:203166198 C/G cg14085262 chr1:203155938 CHI3L1 -0.52 -5.68 -0.33 3.51e-8 YKL-40 levels; CESC cis rs12995491 0.933 rs7590305 chr2:88513131 C/T cg07952391 chr2:88470173 THNSL2 -0.53 -7.7 -0.43 2.69e-13 Response to metformin (IC50); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26566046 chr12:80083628 PAWR 0.46 6.44 0.37 5.69e-10 Gut microbiota (bacterial taxa); CESC cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.34 -5.76 -0.33 2.35e-8 Hemoglobin concentration; CESC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.11 -0.3 6.24e-7 Glomerular filtration rate (creatinine); CESC cis rs9329289 0.510 rs28579610 chr10:2546080 C/A cg15501526 chr10:2543763 NA 0.49 8.01 0.44 3.77e-14 Age-related hearing impairment; CESC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg17747265 chr1:1875780 NA -0.56 -9.05 -0.49 3.1e-17 Body mass index; CESC cis rs1413885 0.549 rs1334879 chr1:65846051 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.46 6.14 0.35 3.05e-9 Anticoagulant levels; CESC cis rs727505 0.954 rs55768077 chr7:124663216 A/G cg23710748 chr7:124431027 NA -0.41 -6.47 -0.37 4.68e-10 Lewy body disease; CESC cis rs1348850 0.632 rs4470372 chr2:178505857 G/A cg22681709 chr2:178499509 PDE11A -0.56 -8.78 -0.47 2.11e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6500395 0.962 rs1564980 chr16:48651377 A/T cg04672837 chr16:48644449 N4BP1 0.49 5.98 0.34 7.31e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs11190604 1.000 rs2495753 chr10:102325640 C/T cg07080220 chr10:102295463 HIF1AN 0.62 5.57 0.32 6.31e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs10484885 0.878 rs72921934 chr6:90579464 T/A cg13799429 chr6:90582589 CASP8AP2 -0.79 -7.55 -0.42 7.1e-13 QRS interval (sulfonylurea treatment interaction); CESC cis rs3820068 0.603 rs7529759 chr1:15977877 A/G cg18133145 chr1:16060689 PLEKHM2 -0.4 -5.09 -0.3 6.65e-7 Systolic blood pressure; CESC cis rs10751667 0.621 rs4075990 chr11:976614 T/C cg06064525 chr11:970664 AP2A2 -0.47 -9.12 -0.49 1.9e-17 Alzheimer's disease (late onset); CESC trans rs4756846 1.000 rs57463944 chr11:16400535 A/C cg05579622 chr5:10618622 ANKRD33B 0.76 6.93 0.39 3.14e-11 Obesity and osteoporosis; CESC cis rs708547 0.836 rs1277287 chr4:57853147 C/G cg14719990 chr4:57843890 C4orf14;POLR2B 0.48 5.27 0.31 2.87e-7 Response to bleomycin (chromatid breaks); CESC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg19193384 chr17:30244184 NA 0.5 5.15 0.3 5.17e-7 Hip circumference adjusted for BMI; CESC cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg22875332 chr1:76189707 ACADM 0.72 10.03 0.52 2.87e-20 Blood metabolite levels;Acylcarnitine levels; CESC trans rs4950322 0.570 rs4593887 chr1:146705892 T/C cg04954894 chr8:38089920 DDHD2 -0.58 -6.17 -0.35 2.55e-9 Protein quantitative trait loci; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05622441 chr16:69419962 TERF2 0.54 6.59 0.38 2.33e-10 Gut microbiome composition (summer); CESC cis rs9913156 0.793 rs56020376 chr17:4560909 A/G cg00122941 chr17:4613640 ARRB2 0.85 9.99 0.52 3.79e-20 Lymphocyte counts; CESC cis rs8114671 0.804 rs6060139 chr20:33566499 T/C cg24642439 chr20:33292090 TP53INP2 0.45 5.37 0.31 1.72e-7 Height; CESC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg02711726 chr17:80685570 FN3KRP 0.42 6.29 0.36 1.32e-9 Glycated hemoglobin levels; CESC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg25956985 chr22:39795188 MAP3K7IP1 -0.51 -5.07 -0.3 7.35e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1577917 0.740 rs2842614 chr6:86306069 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.35 -5.03 -0.3 9.19e-7 Response to antipsychotic treatment; CESC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg15369054 chr17:80825471 TBCD 0.54 7.33 0.41 2.72e-12 Breast cancer; CESC cis rs250677 0.687 rs250678 chr5:148434830 C/T cg18129178 chr5:148520854 ABLIM3 -0.47 -5.45 -0.32 1.13e-7 Breast cancer; CESC cis rs7259376 0.846 rs5014503 chr19:22568340 A/T cg02657401 chr19:22469223 NA -0.25 -5.1 -0.3 6.58e-7 Menopause (age at onset); CESC cis rs3126085 0.935 rs12730241 chr1:152274016 G/A cg03465714 chr1:152285911 FLG 0.51 5.87 0.34 1.32e-8 Atopic dermatitis; CESC cis rs2295499 0.754 rs12499320 chr4:2703081 C/T cg27239842 chr4:2403781 ZFYVE28 -0.32 -5.32 -0.31 2.17e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg07636037 chr3:49044803 WDR6 1.01 18.68 0.75 2.81e-50 Parkinson's disease; CESC cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg13395646 chr4:1353034 KIAA1530 -0.53 -6.35 -0.36 9.49e-10 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26878967 chr11:66459081 SPTBN2 0.5 7.01 0.4 1.93e-11 Fibrinogen levels; CESC cis rs4253772 0.550 rs9615913 chr22:46668515 A/T cg07012999 chr22:46692446 CN5H6.4;GTSE1 -0.52 -5.6 -0.33 5.45e-8 LDL cholesterol;Cholesterol, total; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07213289 chr7:73610504 EIF4H -0.44 -6.27 -0.36 1.48e-9 Gut microbiota (bacterial taxa); CESC cis rs6740322 0.696 rs11685054 chr2:43474295 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.73 -8.71 -0.47 3.34e-16 Coronary artery disease; CESC cis rs7264396 0.790 rs6058288 chr20:34228680 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.84 11.84 0.59 3.11e-26 Total cholesterol levels; CESC cis rs1670533 1.000 rs6812586 chr4:1069851 A/G cg04106633 chr4:1044584 NA 0.4 5.11 0.3 6.07e-7 Recombination rate (females); CESC cis rs8016982 0.617 rs2241621 chr14:81737076 G/T cg01989461 chr14:81687754 GTF2A1 -0.59 -8.4 -0.46 2.66e-15 Schizophrenia; CESC cis rs1348850 0.958 rs11689550 chr2:178456298 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.28 0.45 6.32e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg17372223 chr3:52568218 NT5DC2 0.42 6.2 0.36 2.11e-9 Bipolar disorder; CESC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg14820908 chr5:178986412 RUFY1 -0.5 -7.97 -0.44 4.85e-14 Lung cancer; CESC trans rs1728785 0.818 rs1728772 chr16:68584526 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.48 0.42 1.11e-12 Ulcerative colitis; CESC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg06873352 chr17:61820015 STRADA -0.68 -11.52 -0.58 3.69e-25 Prudent dietary pattern; CESC cis rs763121 0.925 rs9835 chr22:39130971 A/G cg14440974 chr22:39074834 NA -0.35 -5.11 -0.3 6.17e-7 Menopause (age at onset); CESC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg22508957 chr16:3507546 NAT15 -0.69 -7.51 -0.42 8.87e-13 Tuberculosis; CESC cis rs28647808 0.786 rs4962135 chr9:136256630 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg03806693 chr22:41940476 POLR3H 1.08 12.47 0.61 2.2e-28 Crohn's disease;Inflammatory bowel disease; CESC trans rs7095944 0.644 rs965484 chr10:126453481 T/C cg27222157 chr11:66382978 RBM14 0.38 6.13 0.35 3.17e-9 Asthma; CESC cis rs79349575 0.783 rs4399576 chr17:47009835 G/A cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs208520 0.690 rs207094 chr6:66799009 G/A cg07460842 chr6:66804631 NA -1.0 -13.43 -0.64 1.05e-31 Exhaled nitric oxide output; CESC cis rs7633770 0.786 rs1520489 chr3:46677519 A/G cg11219411 chr3:46661640 NA -0.37 -6.2 -0.36 2.12e-9 Coronary artery disease; CESC cis rs5769765 0.773 rs7290751 chr22:50318312 T/C cg26441486 chr22:50317300 CRELD2 0.48 5.78 0.33 2.13e-8 Schizophrenia; CESC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.56 0.37 2.73e-10 Prudent dietary pattern; CESC cis rs68170813 0.559 rs10953531 chr7:106827867 A/G cg02696742 chr7:106810147 HBP1 0.55 5.29 0.31 2.54e-7 Coronary artery disease; CESC cis rs3793917 0.948 rs2284665 chr10:124226630 A/C cg24884230 chr10:124216658 ARMS2 -0.29 -5.07 -0.3 7.6e-7 Age-related macular degeneration; CESC cis rs13064411 0.735 rs10511326 chr3:113216325 T/C cg18753928 chr3:113234510 CCDC52 -0.51 -6.24 -0.36 1.7e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs4642101 0.793 rs13086170 chr3:12832604 G/C cg24848339 chr3:12840334 CAND2 0.35 5.41 0.32 1.4e-7 QRS complex (12-leadsum); CESC cis rs11098499 0.754 rs7672778 chr4:120248585 A/G cg09307838 chr4:120376055 NA 0.78 10.55 0.54 5.92e-22 Corneal astigmatism; CESC cis rs698833 0.886 rs2304770 chr2:44569328 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 6.4 0.37 6.82e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19407570 chr11:61735476 FTH1 -0.46 -6.41 -0.37 6.53e-10 Fibrinogen levels; CESC cis rs60843830 1.000 rs56167434 chr2:282137 G/C cg00108164 chr2:264199 ACP1;SH3YL1 0.78 9.97 0.52 4.29e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs11122272 0.735 rs2790873 chr1:231539685 A/G cg06096015 chr1:231504339 EGLN1 0.41 5.89 0.34 1.15e-8 Hemoglobin concentration; CESC cis rs1843834 0.755 rs10194591 chr2:225574276 T/A cg22455342 chr2:225449267 CUL3 0.46 5.84 0.34 1.49e-8 IgE levels in asthmatics (D.p. specific); CESC cis rs11098499 0.754 rs7672372 chr4:120248406 A/G cg09307838 chr4:120376055 NA 0.78 10.54 0.54 6.4e-22 Corneal astigmatism; CESC cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg10553204 chr2:20871195 GDF7 0.34 5.12 0.3 5.92e-7 Abdominal aortic aneurysm; CESC cis rs7044106 0.762 rs1547268 chr9:123408688 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.14 0.3 5.26e-7 Hip circumference adjusted for BMI; CESC cis rs1451375 0.572 rs745042 chr7:50544138 A/G cg14593290 chr7:50529359 DDC -0.52 -5.94 -0.34 9.11e-9 Malaria; CESC cis rs7904368 0.754 rs12269366 chr10:16850344 G/A cg23933602 chr10:16859644 RSU1 0.67 6.17 0.35 2.54e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs684232 0.666 rs838373 chr17:567171 T/C cg12384639 chr17:618140 VPS53 0.4 5.15 0.3 5.02e-7 Prostate cancer; CESC cis rs7927771 0.524 rs10838732 chr11:47607940 C/G cg20307385 chr11:47447363 PSMC3 0.64 8.77 0.47 2.17e-16 Subjective well-being; CESC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg17724175 chr1:150552817 MCL1 0.45 7.41 0.41 1.75e-12 Melanoma; CESC cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs13360092 1.000 rs76644223 chr5:50558191 C/T cg03200537 chr16:87022121 NA 0.69 6.01 0.35 6.15e-9 Verbal declarative memory; CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg18765753 chr7:1198926 ZFAND2A -0.47 -7.24 -0.41 4.99e-12 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18804080 chr3:25705791 TOP2B 0.62 6.84 0.39 5.51e-11 Gut microbiome composition (summer); CESC cis rs3008870 0.883 rs2755249 chr1:67493662 A/G cg02640540 chr1:67518911 SLC35D1 0.52 5.56 0.32 6.48e-8 Lymphocyte percentage of white cells; CESC cis rs2832191 0.646 rs2832214 chr21:30517127 C/T cg08807101 chr21:30365312 RNF160 -0.47 -5.53 -0.32 7.85e-8 Dental caries; CESC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg06873352 chr17:61820015 STRADA 0.72 12.74 0.62 2.56e-29 Prudent dietary pattern; CESC cis rs1316952 0.831 rs77732168 chr12:124392120 G/C cg12597309 chr12:124393772 DNAH10 0.34 5.16 0.3 4.8e-7 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs72901758 0.768 rs55730737 chr17:76250777 T/A cg26068271 chr17:76253126 NA 0.47 6.6 0.38 2.25e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs1044826 0.642 rs295479 chr3:139223865 C/T cg00490450 chr3:139108681 COPB2 0.45 5.53 0.32 7.8e-8 Obesity-related traits; CESC cis rs6061231 0.631 rs2427317 chr20:60975725 C/T cg06197360 chr20:60970103 CABLES2 -0.4 -5.72 -0.33 2.89e-8 Colorectal cancer; CESC cis rs9905704 0.681 rs4793948 chr17:56562062 G/A cg12560992 chr17:57184187 TRIM37 -0.59 -5.68 -0.33 3.48e-8 Testicular germ cell tumor; CESC trans rs997295 0.529 rs12592315 chr15:68040266 A/G cg03031660 chr17:73257791 MRPS7;GGA3 0.47 6.11 0.35 3.49e-9 Motion sickness; CESC cis rs4722166 0.695 rs7787893 chr7:22774437 A/G cg05472934 chr7:22766657 IL6 0.65 8.85 0.48 1.31e-16 Lung cancer; CESC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.22e-17 Prudent dietary pattern; CESC cis rs4654899 1.000 rs7535895 chr1:21439239 T/A cg05370193 chr1:21551575 ECE1 0.4 6.05 0.35 5.01e-9 Superior frontal gyrus grey matter volume; CESC cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg08999081 chr20:33150536 PIGU -0.51 -7.79 -0.43 1.52e-13 Coronary artery disease; CESC cis rs854765 0.547 rs2955384 chr17:17939573 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 6.2 0.36 2.12e-9 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05566397 chr7:104654900 MLL5;LOC100216545 -0.62 -7.39 -0.41 1.89e-12 Gut microbiome composition (summer); CESC cis rs1371867 0.817 rs1660314 chr8:101332953 C/T cg11906718 chr8:101322791 RNF19A 0.53 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC cis rs11792861 0.781 rs28361152 chr9:111727529 T/C cg05043794 chr9:111880884 C9orf5 -0.38 -6.22 -0.36 1.88e-9 Menarche (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10671167 chr7:39988923 CDK13 -0.42 -6.08 -0.35 4.07e-9 Gambling; CESC cis rs62236223 1 rs62236223 chr22:31863554 T/C cg01338084 chr22:32026380 PISD 1.16 7.13 0.4 9.74e-12 Age-related hearing impairment; CESC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg26314531 chr2:26401878 FAM59B 0.79 7.91 0.44 6.89e-14 Gut microbiome composition (summer); CESC cis rs854765 0.647 rs7212447 chr17:17987067 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 5.97 0.34 7.49e-9 Total body bone mineral density; CESC cis rs870825 0.616 rs4623061 chr4:185643161 A/C cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs1577917 0.958 rs13213899 chr6:86473140 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -6.81 -0.39 6.5500000000000006e-11 Response to antipsychotic treatment; CESC cis rs7824557 0.602 rs11784458 chr8:11204184 G/A cg21775007 chr8:11205619 TDH 0.58 8.85 0.48 1.26e-16 Retinal vascular caliber; CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg24642844 chr7:1081250 C7orf50 -0.38 -5.07 -0.3 7.32e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs548181 0.668 rs579661 chr11:125474766 A/G cg03464685 chr11:125439445 EI24 1.12 9.41 0.5 2.49e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs55823223 0.680 rs57287238 chr17:73850940 T/C cg02397686 chr17:73851076 WBP2 0.59 7.45 0.42 1.29e-12 Psoriasis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19741408 chr1:90460434 ZNF326;LOC492303 -0.45 -6.48 -0.37 4.35e-10 Gambling; CESC cis rs7193541 0.684 rs4888264 chr16:74681632 T/G cg05580060 chr16:74700937 RFWD3 -0.5 -6.46 -0.37 5.01e-10 Multiple myeloma; CESC cis rs1559088 0.947 rs10403238 chr19:33552405 A/G cg17764715 chr19:33622953 WDR88 0.45 5.68 0.33 3.6e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs3780486 0.846 rs4584234 chr9:33147479 G/A cg20290983 chr6:43655470 MRPS18A 0.94 16.54 0.71 1.02e-42 IgG glycosylation; CESC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg12718519 chr1:2058417 PRKCZ 0.27 5.78 0.33 2.06e-8 Height; CESC cis rs477692 0.569 rs1771448 chr10:131296201 A/G cg05714579 chr10:131428358 MGMT -0.41 -5.42 -0.32 1.31e-7 Response to temozolomide; CESC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg03806693 chr22:41940476 POLR3H -1.19 -14.75 -0.67 2.43e-36 Vitiligo; CESC cis rs713587 0.776 rs1172294 chr2:25169200 A/G cg01884057 chr2:25150051 NA 0.39 7.42 0.41 1.64e-12 Body mass index in non-asthmatics; CESC cis rs57221529 0.600 rs11750269 chr5:666270 G/A cg16447950 chr5:562315 NA -0.62 -6.33 -0.36 1.02e-9 Lung disease severity in cystic fibrosis; CESC cis rs921968 0.678 rs660432 chr2:219432127 C/T cg02176678 chr2:219576539 TTLL4 0.39 6.8 0.39 6.94e-11 Mean corpuscular hemoglobin concentration; CESC cis rs2228479 0.571 rs62052183 chr16:89966921 C/A cg06558623 chr16:89946397 TCF25 1.05 8.66 0.47 4.66e-16 Skin colour saturation; CESC cis rs78456975 1.000 rs11899027 chr2:1560414 G/C cg26248373 chr2:1572462 NA -0.59 -5.7 -0.33 3.11e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.72 -10.35 -0.54 2.6e-21 Monocyte percentage of white cells; CESC cis rs9487051 0.676 rs6925716 chr6:109597641 T/C cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.61e-11 Reticulocyte fraction of red cells; CESC cis rs72781680 0.752 rs55859418 chr2:23904231 C/A cg08917208 chr2:24149416 ATAD2B 1.18 10.67 0.55 2.49e-22 Lymphocyte counts; CESC trans rs35146811 0.735 rs858512 chr7:99824453 A/G cg13215871 chr17:75784724 NA -0.34 -6.39 -0.37 7.46e-10 Coronary artery disease; CESC cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg22875332 chr1:76189707 ACADM 0.69 9.24 0.49 8.13e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2439831 0.850 rs2277531 chr15:44069069 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.88 0.44 8.75e-14 Lung cancer in ever smokers; CESC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg13902645 chr11:5959945 NA -0.67 -9.11 -0.49 2.14e-17 DNA methylation (variation); CESC cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.49 6.13 0.35 3.26e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs698813 0.774 rs2304769 chr2:44569474 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 6.25 0.36 1.62e-9 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg04450456 chr4:17643702 FAM184B 0.39 5.68 0.33 3.54e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7605827 0.930 rs6750232 chr2:15714958 C/T cg19274914 chr2:15703543 NA 0.36 6.5 0.37 4.03e-10 Educational attainment (years of education); CESC cis rs909674 0.731 rs6001594 chr22:39837472 C/T cg01416388 chr22:39784598 NA -0.62 -7.64 -0.42 3.97e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs867529 0.620 rs335121 chr2:89084327 G/C cg26627705 chr2:89060884 NA 0.41 5.66 0.33 3.86e-8 Height; CESC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg24503407 chr1:205819492 PM20D1 0.82 13.96 0.65 1.43e-33 Menarche (age at onset); CESC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg26839252 chr6:160211577 TCP1;MRPL18 0.47 5.38 0.31 1.61e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg18765753 chr7:1198926 ZFAND2A -0.44 -5.52 -0.32 7.99e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7542091 0.704 rs1108628 chr1:210041150 A/G cg23283495 chr1:209979779 IRF6 0.33 5.2 0.3 3.98e-7 Monobrow; CESC cis rs116095464 0.558 rs28635197 chr5:279071 T/C cg10591111 chr5:226296 SDHA -0.53 -6.43 -0.37 6.03e-10 Breast cancer; CESC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg21770322 chr7:97807741 LMTK2 0.55 8.3 0.45 5.37e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs9911578 1.000 rs8067571 chr17:56868856 C/T cg12560992 chr17:57184187 TRIM37 0.92 15.58 0.69 2.71e-39 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08161947 chr12:19592900 AEBP2 0.63 6.99 0.39 2.21e-11 Gut microbiome composition (summer); CESC cis rs4704187 0.687 rs4704197 chr5:74537751 C/T cg03227963 chr5:74354835 NA 0.27 5.04 0.3 8.67e-7 Response to amphetamines; CESC trans rs1814175 0.645 rs1851849 chr11:50012164 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -6.12 -0.35 3.32e-9 Height; CESC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg26939375 chr7:64535504 NA 0.48 6.2 0.36 2.12e-9 Aortic root size; CESC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg13206674 chr6:150067644 NUP43 -0.41 -5.66 -0.33 3.85e-8 Lung cancer; CESC cis rs2066819 1.000 rs57279772 chr12:56698960 G/A cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg00934597 chr7:893267 UNC84A 0.56 5.65 0.33 4.17e-8 Cerebrospinal P-tau181p levels; CESC cis rs8017423 0.935 rs11159960 chr14:90740012 C/T cg14092571 chr14:90743983 NA 0.56 8.49 0.46 1.54e-15 Mortality in heart failure; CESC cis rs11098499 0.909 rs2127821 chr4:120394535 T/C cg09307838 chr4:120376055 NA 0.94 13.95 0.65 1.51e-33 Corneal astigmatism; CESC cis rs3733418 0.860 rs13141887 chr4:165950921 C/T cg10852876 chr4:165953100 TRIM60 -0.47 -5.49 -0.32 9.39e-8 Obesity-related traits; CESC cis rs9911578 0.967 rs12944948 chr17:56951474 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.94 -0.39 2.94e-11 Intelligence (multi-trait analysis); CESC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg03388025 chr16:89894329 SPIRE2 -0.39 -7.6 -0.42 5.15e-13 Vitiligo; CESC cis rs12050794 0.636 rs4506844 chr15:72509138 C/T cg16672083 chr15:72433130 SENP8 0.45 6.62 0.38 1.99e-10 Metabolite levels (HVA/MHPG ratio); CESC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.81 0.39 6.69e-11 Bipolar disorder; CESC cis rs67311347 1.000 rs28491638 chr3:40496263 T/C cg09455208 chr3:40491958 NA 0.5 7.96 0.44 5.11e-14 Renal cell carcinoma; CESC cis rs9487051 0.714 rs7774377 chr6:109602443 G/A cg01475377 chr6:109611718 NA -0.44 -6.97 -0.39 2.52e-11 Reticulocyte fraction of red cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03093076 chr19:1390962 NDUFS7 0.48 6.27 0.36 1.5e-9 Fibrinogen levels; CESC cis rs9926296 0.643 rs2159114 chr16:89831841 A/G cg27121462 chr16:89883253 FANCA 0.52 6.32 0.36 1.1e-9 Vitiligo; CESC cis rs4555082 1.000 rs7146012 chr14:105757566 G/A cg13114125 chr14:105738426 BRF1 -0.75 -9.57 -0.51 7.69e-19 Mean platelet volume;Platelet distribution width; CESC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.08 0.53 1.93e-20 Prudent dietary pattern; CESC cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg14061069 chr19:46274453 DMPK 0.55 8.49 0.46 1.5e-15 Coronary artery disease; CESC cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg09555818 chr19:45449301 APOC2 0.41 6.55 0.37 3.05e-10 Blood protein levels; CESC cis rs4481887 0.861 rs4309013 chr1:248480768 C/T cg00666640 chr1:248458726 OR2T12 0.36 5.98 0.34 7.16e-9 Common traits (Other); CESC cis rs4689388 0.824 rs6446482 chr4:6295693 C/G cg25554036 chr4:6271136 WFS1 0.52 8.46 0.46 1.79e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs763121 0.819 rs4560233 chr22:38982442 A/T cg06544989 chr22:39130855 UNC84B 0.47 8.01 0.44 3.77e-14 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14620208 chr9:140652685 EHMT1 -0.66 -7.76 -0.43 1.8e-13 Gut microbiome composition (summer); CESC cis rs11711311 0.911 rs3773681 chr3:113523901 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.17 0.53 1.02e-20 IgG glycosylation; CESC cis rs66530629 0.874 rs7548438 chr1:25098341 C/T cg22509179 chr1:25234806 RUNX3 -0.44 -5.64 -0.33 4.27e-8 Plateletcrit; CESC cis rs8077889 1.000 rs2066725 chr17:41891473 A/G cg26893861 chr17:41843967 DUSP3 0.78 10.32 0.54 3.4e-21 Triglycerides; CESC cis rs2204008 0.777 rs2387813 chr12:38382091 A/C cg26384229 chr12:38710491 ALG10B 0.69 10.49 0.54 8.95e-22 Bladder cancer; CESC cis rs1008375 0.606 rs6828925 chr4:17561139 C/T cg27347728 chr4:17578864 LAP3 0.41 5.17 0.3 4.67e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1153858 1.000 rs12591058 chr15:45640172 T/C cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs4319547 0.737 rs10773176 chr12:122944713 A/G cg05707623 chr12:122985044 ZCCHC8 -0.57 -7.03 -0.4 1.75e-11 Body mass index; CESC cis rs4835473 0.932 rs7666368 chr4:144706525 C/A cg25736465 chr4:144833511 NA -0.33 -5.43 -0.32 1.28e-7 Immature fraction of reticulocytes; CESC cis rs7312933 0.932 rs10880220 chr12:42383046 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.39 5.09 0.3 6.77e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs8031584 0.651 rs28664821 chr15:31172323 G/A cg14298792 chr15:30685198 CHRFAM7A 0.47 5.78 0.33 2.08e-8 Huntington's disease progression; CESC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg15145296 chr3:125709740 NA -0.45 -5.14 -0.3 5.34e-7 Blood pressure (smoking interaction); CESC cis rs4566357 0.615 rs10190621 chr2:227914484 A/G cg11843606 chr2:227700838 RHBDD1 -0.49 -6.8 -0.39 7.03e-11 Coronary artery disease; CESC cis rs854765 0.575 rs7207821 chr17:17891781 A/G cg16928487 chr17:17741425 SREBF1 -0.53 -8.72 -0.47 3.12e-16 Total body bone mineral density; CESC cis rs7904368 0.951 rs7905776 chr10:16853609 C/T cg23933602 chr10:16859644 RSU1 0.78 9.04 0.49 3.35e-17 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg06481639 chr22:41940642 POLR3H -0.7 -7.05 -0.4 1.52e-11 Vitiligo; CESC cis rs35306767 0.903 rs11253504 chr10:956046 A/G cg10556349 chr10:835070 NA 0.66 6.32 0.36 1.08e-9 Eosinophil percentage of granulocytes; CESC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg18446336 chr7:2847575 GNA12 -0.39 -5.9 -0.34 1.11e-8 Height; CESC cis rs77956314 0.818 rs12296869 chr12:117431203 G/A cg02017074 chr12:117425053 FBXW8 -0.9 -8.49 -0.46 1.5e-15 Subcortical brain region volumes;Hippocampal volume; CESC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg26343298 chr8:95960752 TP53INP1 0.36 5.98 0.34 7.06e-9 Type 2 diabetes; CESC cis rs6963495 0.818 rs6957192 chr7:105150255 A/C cg19920283 chr7:105172520 RINT1 -0.66 -6.38 -0.36 7.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs7178572 0.568 rs28524916 chr15:77599002 T/A cg22256960 chr15:77711686 NA 0.53 6.37 0.36 8.52e-10 Type 2 diabetes; CESC cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg21395723 chr22:39101663 GTPBP1 -0.43 -5.18 -0.3 4.43e-7 Menopause (age at onset); CESC cis rs4835473 0.897 rs13140654 chr4:144656886 A/G cg25736465 chr4:144833511 NA -0.36 -5.52 -0.32 7.97e-8 Immature fraction of reticulocytes; CESC cis rs1568889 0.838 rs7127069 chr11:28325412 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 13.56 0.64 3.65e-32 Bipolar disorder; CESC cis rs5758659 0.714 rs7245 chr22:42481849 G/A cg04733989 chr22:42467013 NAGA -0.42 -5.71 -0.33 3.01e-8 Cognitive function; CESC cis rs644799 0.511 rs12791736 chr11:95475399 C/G cg25478527 chr11:95522999 CEP57;FAM76B 0.41 5.11 0.3 6.28e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg27165867 chr14:105738592 BRF1 -0.51 -5.45 -0.32 1.13e-7 Mean platelet volume;Platelet distribution width; CESC cis rs6674176 0.628 rs2240447 chr1:44415415 C/T cg13606994 chr1:44402422 ARTN -0.37 -5.53 -0.32 7.66e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9916302 0.706 rs4332770 chr17:37704712 T/C cg07936489 chr17:37558343 FBXL20 -0.98 -11.47 -0.58 5.54e-25 Glomerular filtration rate (creatinine); CESC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg25036284 chr2:26402008 FAM59B -0.59 -6.88 -0.39 4.37e-11 Gut microbiome composition (summer); CESC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg11764359 chr7:65958608 NA 0.71 9.4 0.5 2.68e-18 Aortic root size; CESC cis rs7116495 0.609 rs4944243 chr11:71674354 T/C cg26138937 chr11:71823887 C11orf51 -1.25 -7.99 -0.44 4.19e-14 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20889476 chr12:72057658 THAP2;ZFC3H1 0.56 6.13 0.35 3.19e-9 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03474219 chr11:64072691 ESRRA -0.4 -6.45 -0.37 5.39e-10 Gambling; CESC cis rs8103278 1.000 rs7252126 chr19:46302374 T/A cg14061069 chr19:46274453 DMPK -0.4 -5.4 -0.31 1.51e-7 Coronary artery disease; CESC cis rs7264396 0.676 rs6060727 chr20:34556000 G/A cg17201900 chr20:34330562 RBM39 0.51 5.31 0.31 2.37e-7 Total cholesterol levels; CESC cis rs950027 0.620 rs2461700 chr15:45640627 T/C cg21132104 chr15:45694354 SPATA5L1 0.67 8.55 0.46 1.01e-15 Response to fenofibrate (adiponectin levels); CESC cis rs11864453 0.713 rs7191127 chr16:72123992 G/T cg16558253 chr16:72132732 DHX38 -0.56 -8.7 -0.47 3.62e-16 Fibrinogen levels; CESC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs2290720 0.798 rs10778114 chr12:101745285 G/A cg22051763 chr12:101673672 UTP20 -0.44 -5.52 -0.32 8.14e-8 Brain structure (hippocampal volume); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22976360 chr2:70528671 FAM136A 0.58 6.24 0.36 1.74e-9 Gut microbiome composition (summer); CESC cis rs11098499 0.954 rs7656252 chr4:120404268 T/C cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.1e-8 Corneal astigmatism; CESC cis rs12220238 0.915 rs75467340 chr10:75907318 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.26 0.36 1.58e-9 Soluble interleukin-2 receptor subunit alpha; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22934568 chr3:48884614 PRKAR2A 0.59 6.7 0.38 1.24e-10 Gut microbiome composition (summer); CESC cis rs6831352 0.819 rs1154401 chr4:100009738 G/C cg13256891 chr4:100009986 ADH5 0.66 8.13 0.45 1.68e-14 Alcohol dependence; CESC cis rs11864453 0.963 rs7185215 chr16:72034864 T/C cg16558253 chr16:72132732 DHX38 -0.45 -6.59 -0.38 2.37e-10 Fibrinogen levels; CESC cis rs4891159 0.513 rs2554831 chr18:74113513 C/G cg24786174 chr18:74118243 ZNF516 0.85 15.75 0.7 7e-40 Longevity; CESC cis rs2228479 0.850 rs17233448 chr16:89816424 G/T cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.46 -0.32 1.12e-7 Aortic root size; CESC cis rs9926296 0.712 rs2437957 chr16:89715648 G/A cg04287289 chr16:89883240 FANCA -0.48 -5.84 -0.34 1.48e-8 Vitiligo; CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.38 -5.7 -0.33 3.19e-8 Electroencephalogram traits; CESC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg08888203 chr3:10149979 C3orf24 -0.47 -5.39 -0.31 1.55e-7 Alzheimer's disease; CESC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg25204440 chr1:209979598 IRF6 0.62 7.95 0.44 5.25e-14 Cleft lip with or without cleft palate; CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg04234412 chr22:24373322 LOC391322 -0.65 -9.77 -0.51 1.86e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7216064 0.532 rs8065296 chr17:66018562 T/A cg12091567 chr17:66097778 LOC651250 0.86 11.3 0.57 1.95e-24 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6831352 0.918 rs6813415 chr4:100048509 T/C cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17846100 chr22:43538986 MCAT 0.53 6.41 0.37 6.7e-10 Gut microbiome composition (summer); CESC cis rs2635047 1.000 rs2684818 chr18:44712965 C/T cg24371990 chr18:44770781 NA 0.34 5.46 0.32 1.08e-7 Educational attainment; CESC cis rs11552708 0.504 rs8082166 chr17:7388728 G/C cg02795151 chr17:7402630 POLR2A 0.55 5.86 0.34 1.41e-8 IgM levels; CESC trans rs5756813 0.661 rs6000898 chr22:38202399 T/C cg19894588 chr14:64061835 NA -0.68 -8.42 -0.46 2.36e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg08859206 chr1:53392774 SCP2 -0.63 -8.71 -0.47 3.46e-16 Monocyte count; CESC cis rs9911578 0.967 rs1267542 chr17:56654690 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.19 -0.3 4.25e-7 Intelligence (multi-trait analysis); CESC cis rs2204008 0.626 rs11520260 chr12:38330092 C/T cg26384229 chr12:38710491 ALG10B 0.73 10.9 0.56 4.29e-23 Bladder cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19463885 chr2:242626846 DTYMK 0.49 6.33 0.36 1.03e-9 Gut microbiota (bacterial taxa); CESC cis rs807669 0.586 rs5746671 chr22:19160899 A/G cg02655711 chr22:19163373 SLC25A1 0.44 6.24 0.36 1.7e-9 Metabolite levels; CESC cis rs3820068 0.532 rs72647105 chr1:15935238 C/G cg17385448 chr1:15911702 AGMAT 0.41 6.59 0.38 2.42e-10 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01750847 chr16:30007184 HIRIP3;INO80E 0.66 8.09 0.45 2.2e-14 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19742111 chr11:66460113 SPTBN2 0.53 7.37 0.41 2.11e-12 Fibrinogen levels; CESC cis rs6032067 0.538 rs13041506 chr20:43739655 G/A cg10761708 chr20:43804764 PI3 0.45 5.11 0.3 6.08e-7 Blood protein levels; CESC cis rs1371867 0.875 rs1788173 chr8:101330939 A/G cg11906718 chr8:101322791 RNF19A -0.46 -5.97 -0.34 7.62e-9 Atrioventricular conduction; CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg09177884 chr7:1199841 ZFAND2A -0.56 -6.21 -0.36 2.06e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs77741769 0.529 rs3901854 chr12:121225526 C/T cg02419362 chr12:121203948 SPPL3 0.35 5.72 0.33 2.83e-8 Mean corpuscular volume; CESC cis rs11249608 0.548 rs17078991 chr5:178459426 A/C cg01312482 chr5:178451176 ZNF879 -0.45 -6.08 -0.35 4.26e-9 Pubertal anthropometrics; CESC trans rs765547 0.956 rs1992443 chr8:19853587 G/A cg12649343 chr22:47023005 GRAMD4 -0.3 -6.12 -0.35 3.27e-9 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs11785400 0.731 rs4294163 chr8:143730830 G/T cg24634471 chr8:143751801 JRK 0.45 5.78 0.33 2.12e-8 Schizophrenia; CESC cis rs1642645 0.831 rs6698877 chr1:42500436 T/C cg16685388 chr1:42384056 HIVEP3 0.38 5.68 0.33 3.52e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs3857536 0.842 rs2188591 chr6:66939511 A/T cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.37 -5.98 -0.34 7.09e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7833986 0.534 rs17759244 chr8:57033768 A/G cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.41 0.32 1.42e-7 Height; CESC cis rs3820068 0.608 rs7552400 chr1:16035892 A/G cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.64e-7 Systolic blood pressure; CESC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg04369109 chr6:150039330 LATS1 -0.41 -5.75 -0.33 2.48e-8 Lung cancer; CESC cis rs9302635 0.513 rs3812987 chr16:72158920 C/A cg16558253 chr16:72132732 DHX38 -0.42 -5.41 -0.32 1.42e-7 Blood protein levels; CESC cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.08 0.4 1.32e-11 Height; CESC cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg04455712 chr21:45112962 RRP1B 0.37 5.53 0.32 7.48e-8 Mean corpuscular volume; CESC cis rs1707322 0.752 rs28890893 chr1:46186576 T/G cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7592578 0.771 rs12052514 chr2:191378170 C/T cg10560079 chr2:191398806 TMEM194B -0.61 -5.53 -0.32 7.74e-8 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03794801 chr17:33817159 SLFN12L -0.52 -6.25 -0.36 1.59e-9 Gut microbiome composition (summer); CESC cis rs2439831 0.681 rs2278858 chr15:43632755 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.85 9.76 0.51 2.03e-19 Lung cancer in ever smokers; CESC cis rs8002861 0.875 rs12872943 chr13:44410553 G/A cg14210620 chr13:44453864 C13orf31;CCDC122 -0.42 -5.33 -0.31 2.16e-7 Leprosy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08201673 chr17:18167551 SMCR7 -0.61 -6.86 -0.39 4.99e-11 Gut microbiome composition (summer); CESC cis rs7647973 0.848 rs4955411 chr3:49145304 A/G cg07636037 chr3:49044803 WDR6 0.9 12.49 0.61 1.87e-28 Menarche (age at onset); CESC cis rs13242816 1.000 rs36011826 chr7:116118336 G/A cg04696780 chr7:116139425 CAV2 -0.58 -5.15 -0.3 5.21e-7 P wave duration; CESC cis rs12681366 0.762 rs7831073 chr8:95354366 C/G cg13257157 chr8:95487014 RAD54B 0.41 5.55 0.32 6.83e-8 Nonsyndromic cleft lip with cleft palate; CESC cis rs2839186 0.967 rs2839191 chr21:47695395 C/G cg10351095 chr21:47802916 PCNT -0.47 -6.55 -0.37 2.89e-10 Testicular germ cell tumor; CESC cis rs17784882 0.524 rs7433300 chr3:47120640 G/A cg27129171 chr3:47204927 SETD2 0.64 9.09 0.49 2.35e-17 QT interval; CESC cis rs4654899 0.772 rs7548269 chr1:21089472 T/C cg05370193 chr1:21551575 ECE1 0.35 5.14 0.3 5.4e-7 Superior frontal gyrus grey matter volume; CESC cis rs12500824 0.528 rs62303260 chr4:77286660 G/T cg20311846 chr4:77356250 SHROOM3 0.37 6.86 0.39 4.82e-11 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05031202 chr17:7738649 NA -0.68 -7.92 -0.44 6.63e-14 Gut microbiome composition (summer); CESC cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg06784218 chr1:46089804 CCDC17 -0.3 -5.11 -0.3 6.3e-7 High light scatter reticulocyte count; CESC cis rs10752881 0.809 rs3738829 chr1:183113862 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.21 0.63 5.85e-31 Colorectal cancer; CESC cis rs2573652 1.000 rs2727198 chr15:100513722 T/C cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.49 -0.32 9.48e-8 Height; CESC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.07 20.16 0.78 1.92e-55 Prudent dietary pattern; CESC cis rs80130819 0.748 rs2409001 chr12:48594490 T/C cg05342945 chr12:48394962 COL2A1 -0.57 -6.11 -0.35 3.6e-9 Prostate cancer; CESC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg19163074 chr7:65112434 INTS4L2 0.43 5.48 0.32 1.01e-7 Aortic root size; CESC cis rs5758511 0.514 rs5751222 chr22:42517922 T/A cg00645731 chr22:42541494 CYP2D7P1 0.63 9.78 0.52 1.69e-19 Birth weight; CESC cis rs4308124 0.708 rs7585313 chr2:111975203 A/G cg04571233 chr2:111982156 NA -0.62 -6.89 -0.39 4.12e-11 Vitiligo; CESC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg01238044 chr22:24384105 GSTT1 -0.52 -6.54 -0.37 3.15e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg02592271 chr2:27665507 KRTCAP3 -0.3 -5.99 -0.35 6.92e-9 Total body bone mineral density; CESC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg13798912 chr7:905769 UNC84A 0.56 5.7 0.33 3.11e-8 Cerebrospinal P-tau181p levels; CESC cis rs6088590 1.000 rs6120708 chr20:33335526 G/A cg06115741 chr20:33292138 TP53INP2 0.57 7.02 0.4 1.83e-11 Coronary artery disease; CESC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg18099408 chr3:52552593 STAB1 -0.31 -5.09 -0.3 6.68e-7 Bipolar disorder; CESC cis rs78456975 0.506 rs10167704 chr2:1571037 G/C cg26248373 chr2:1572462 NA -0.6 -6.98 -0.39 2.43e-11 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4076764 0.914 rs7536270 chr1:163377379 T/C cg24596788 chr1:163392923 NA -0.51 -7.52 -0.42 8.59e-13 Motion sickness; CESC cis rs9362426 0.551 rs6912282 chr6:88103000 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.46 5.4 0.32 1.45e-7 Depressive episodes in bipolar disorder; CESC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Lung function (FEV1); CESC cis rs709400 0.832 rs55864158 chr14:104068579 G/A cg24130564 chr14:104152367 KLC1 -0.43 -5.1 -0.3 6.5e-7 Body mass index; CESC cis rs12597458 0.763 rs7195958 chr16:72036577 A/G cg01557791 chr16:72042693 DHODH 0.81 12.44 0.61 2.76e-28 Prostate cancer; CESC cis rs9303280 0.840 rs12939457 chr17:38032188 T/C cg19468946 chr17:37922297 IKZF3 -0.41 -5.48 -0.32 1.01e-7 Self-reported allergy; CESC cis rs2228479 0.850 rs17227064 chr16:89816314 A/G cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs1707322 0.682 rs12041197 chr1:46104464 T/C cg06784218 chr1:46089804 CCDC17 0.4 6.99 0.39 2.23e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9324022 0.929 rs1004574 chr14:101178067 C/G cg18089426 chr14:101175970 NA 0.62 7.98 0.44 4.5e-14 Plateletcrit; CESC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg21782813 chr7:2030301 MAD1L1 0.39 5.49 0.32 9.33e-8 Bipolar disorder and schizophrenia; CESC cis rs7937682 0.883 rs568506 chr11:111466429 C/T cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC cis rs2073300 0.609 rs6137950 chr20:23418722 T/A cg16736954 chr20:23401023 NAPB 0.78 5.78 0.33 2.05e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.53 5.9 0.34 1.12e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9549367 0.577 rs3024713 chr13:113813321 G/A cg00898013 chr13:113819073 PROZ -0.49 -6.19 -0.36 2.27e-9 Platelet distribution width; CESC cis rs6500395 1.000 rs7206647 chr16:48709220 G/C cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2573652 0.722 rs12904962 chr15:100544113 A/G cg09918751 chr15:100517450 ADAMTS17 0.32 5.8 0.34 1.86e-8 Height; CESC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg18876405 chr7:65276391 NA -0.53 -7.38 -0.41 2.09e-12 Aortic root size; CESC cis rs7267979 1.000 rs6050599 chr20:25400240 T/C cg08601574 chr20:25228251 PYGB -0.37 -5.36 -0.31 1.77e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 0.967 rs1588322 chr17:56990099 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.41 5.41 0.32 1.38e-7 Intelligence (multi-trait analysis); CESC cis rs6500395 0.775 rs1968903 chr16:48664014 C/T cg04672837 chr16:48644449 N4BP1 0.49 6.27 0.36 1.46e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs35110281 0.626 rs162389 chr21:44936227 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 6.07 0.35 4.34e-9 Mean corpuscular volume; CESC trans rs10463316 0.894 rs7723016 chr5:150764828 T/C cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.44 6.04 0.35 5.16e-9 Lymphocyte counts; CESC cis rs9300255 0.602 rs1727296 chr12:123647725 G/C cg05973401 chr12:123451056 ABCB9 0.5 5.81 0.34 1.79e-8 Neutrophil percentage of white cells; CESC cis rs9560113 0.573 rs9560134 chr13:112244011 C/T cg10483660 chr13:112241077 NA 0.42 6.99 0.39 2.21e-11 Menarche (age at onset); CESC cis rs2204008 0.744 rs66474616 chr12:38461564 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.57 0.54 5.01e-22 Bladder cancer; CESC trans rs899596 0.908 rs2127434 chr17:71737392 C/T cg23413066 chr4:13548755 LOC285548 0.39 6.13 0.35 3.17e-9 Glucose homeostasis traits; CESC cis rs4474465 0.850 rs4597089 chr11:78262244 A/G cg27205649 chr11:78285834 NARS2 0.4 5.11 0.3 6.22e-7 Alzheimer's disease (survival time); CESC cis rs9303280 0.806 rs2872507 chr17:38040763 C/T cg20243544 chr17:37824526 PNMT 0.48 6.3 0.36 1.21e-9 Self-reported allergy; CESC cis rs477692 0.692 rs12265758 chr10:131445144 A/G cg24747557 chr10:131355152 MGMT 0.38 5.27 0.31 2.78e-7 Response to temozolomide; CESC cis rs116095464 0.614 rs78905930 chr5:246560 G/A cg22857025 chr5:266934 NA -1.25 -16.91 -0.72 5.34e-44 Breast cancer; CESC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg15052019 chr19:19431593 KIAA0892;SF4 -0.41 -5.2 -0.3 3.93e-7 Tonsillectomy; CESC cis rs1144333 0.850 rs1144341 chr1:76282659 T/G cg22875332 chr1:76189707 ACADM -0.54 -5.25 -0.31 3.11e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs2797160 0.875 rs12527010 chr6:125991507 A/G cg05901451 chr6:126070800 HEY2 0.46 6.74 0.38 1.01e-10 Endometrial cancer; CESC cis rs17376456 0.877 rs10057605 chr5:93443950 T/G cg25358565 chr5:93447407 FAM172A 1.22 11.3 0.57 2.03e-24 Diabetic retinopathy; CESC cis rs1559088 1.000 rs2161225 chr19:33551899 C/T cg27124370 chr19:33622961 WDR88 0.43 5.47 0.32 1.04e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs796364 0.950 rs188146 chr2:200750444 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.84 8.22 0.45 9.15e-15 Schizophrenia; CESC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg05564831 chr3:52568323 NT5DC2 0.44 6.73 0.38 1.02e-10 Bipolar disorder; CESC cis rs17001868 0.568 rs9611314 chr22:40735798 C/G cg07138101 chr22:40742427 ADSL 0.55 5.26 0.31 3e-7 Mammographic density (dense area); CESC cis rs4319547 0.695 rs10744211 chr12:122931820 A/G cg23029597 chr12:123009494 RSRC2 -0.45 -5.08 -0.3 7.04e-7 Body mass index; CESC cis rs7267979 0.868 rs6138553 chr20:25239233 G/A cg08601574 chr20:25228251 PYGB 0.43 6.05 0.35 5.03e-9 Liver enzyme levels (alkaline phosphatase); CESC cis rs7799006 0.691 rs10447541 chr7:2301578 T/G cg08027265 chr7:2291960 NA -0.6 -10.21 -0.53 7.27e-21 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12586317 0.547 rs13379372 chr14:35483882 A/C cg05294307 chr14:35346193 BAZ1A -0.51 -5.48 -0.32 1.01e-7 Psoriasis; CESC cis rs17401966 0.838 rs12139981 chr1:10390696 T/C cg15208524 chr1:10270712 KIF1B 0.39 5.03 0.3 8.95e-7 Hepatocellular carcinoma; CESC trans rs2018683 0.707 rs1021691 chr7:28974496 C/T cg19402173 chr7:128379420 CALU -0.49 -6.51 -0.37 3.68e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs11718455 0.960 rs6781618 chr3:44001933 C/T cg08738300 chr3:44038990 NA 0.46 6.13 0.35 3.17e-9 Coronary artery disease; CESC trans rs2018683 0.707 rs1874974 chr7:28967647 G/C cg19402173 chr7:128379420 CALU -0.53 -7.12 -0.4 1.04e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg23161317 chr6:28129485 ZNF389 0.51 6.38 0.36 7.9e-10 Parkinson's disease; CESC trans rs2207136 0.771 rs7744992 chr6:50909541 G/A cg06522515 chr3:184090630 THPO -0.36 -6.19 -0.36 2.26e-9 Myopia; CESC cis rs1144333 0.850 rs1146651 chr1:76273594 C/A cg10523679 chr1:76189770 ACADM -0.57 -5.44 -0.32 1.22e-7 Attention function in attention deficit hyperactive disorder; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg19318450 chr21:34852305 TMEM50B -0.43 -6.42 -0.37 6.33e-10 Breast cancer; CESC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg26343298 chr8:95960752 TP53INP1 0.38 6.22 0.36 1.89e-9 Type 2 diabetes; CESC trans rs7980799 0.935 rs1905427 chr12:33534368 T/C cg26384229 chr12:38710491 ALG10B -0.46 -6.25 -0.36 1.61e-9 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs9322193 0.576 rs7452592 chr6:150196581 A/G cg01145232 chr6:150245071 RAET1G 0.5 5.55 0.32 6.97e-8 Lung cancer; CESC cis rs10242455 0.702 rs73397447 chr7:99010949 G/T cg18809830 chr7:99032528 PTCD1 -0.95 -6.5 -0.37 4e-10 Blood metabolite levels; CESC cis rs8114671 0.836 rs2425006 chr20:33571228 T/G cg24642439 chr20:33292090 TP53INP2 -0.43 -5.17 -0.3 4.68e-7 Height; CESC cis rs4253772 0.591 rs9615934 chr22:46682310 C/G cg24881330 chr22:46731750 TRMU 0.87 7.19 0.4 6.64e-12 LDL cholesterol;Cholesterol, total; CESC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg23161317 chr6:28129485 ZNF389 0.47 5.89 0.34 1.18e-8 Depression; CESC cis rs748404 0.697 rs1095389 chr15:43566671 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.83 0.43 1.19e-13 Lung cancer; CESC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg04166393 chr7:2884313 GNA12 0.52 6.58 0.37 2.5e-10 Height; CESC cis rs2777491 1.000 rs7168177 chr15:41715585 A/G cg20272979 chr15:41787780 ITPKA 0.45 6.68 0.38 1.42e-10 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00711773 chr3:40351057 EIF1B 0.6 6.92 0.39 3.42e-11 Gut microbiome composition (summer); CESC cis rs4566357 0.615 rs2396445 chr2:227917726 C/G cg11843606 chr2:227700838 RHBDD1 -0.54 -7.0 -0.39 2.12e-11 Coronary artery disease; CESC cis rs7937682 0.889 rs541198 chr11:111475340 A/G cg22437258 chr11:111473054 SIK2 0.72 9.69 0.51 3.38e-19 Primary sclerosing cholangitis; CESC cis rs17023223 0.581 rs10923750 chr1:119650795 T/G cg05756136 chr1:119680316 WARS2 -0.46 -5.58 -0.32 5.88e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg11965913 chr1:205819406 PM20D1 0.83 13.41 0.64 1.17e-31 Menarche (age at onset); CESC cis rs10416265 0.502 rs7245411 chr19:33543029 A/T cg17764715 chr19:33622953 WDR88 0.59 8.03 0.44 3.26e-14 Bone properties (heel); CESC cis rs524023 0.958 rs2021860 chr11:64361384 G/T cg07220939 chr11:64358617 SLC22A12 -0.36 -5.55 -0.32 7.08e-8 Urate levels in obese individuals; CESC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg02951883 chr7:2050386 MAD1L1 -0.49 -6.51 -0.37 3.8e-10 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04136590 chr5:114505766 TRIM36 -0.59 -6.46 -0.37 4.85e-10 Gut microbiome composition (summer); CESC cis rs67072384 0.818 rs12287481 chr11:72472336 A/C cg04827223 chr11:72435913 ARAP1 0.71 7.01 0.4 1.97e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs9914578 1.000 rs9914577 chr17:2005130 C/T cg16513277 chr17:2031491 SMG6 -0.58 -6.67 -0.38 1.51e-10 Body mass index; CESC cis rs9811920 0.609 rs793447 chr3:99598278 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs7666738 0.606 rs28625338 chr4:99076996 A/G cg07917127 chr4:99064746 C4orf37 0.4 5.05 0.3 8.3e-7 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs7715108 chr5:264661 A/G cg20965017 chr5:231967 SDHA -0.48 -5.43 -0.32 1.25e-7 Breast cancer; CESC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg11764359 chr7:65958608 NA 0.96 15.81 0.7 4.26e-40 Aortic root size; CESC cis rs11190604 1.000 rs7477246 chr10:102261538 C/T cg07080220 chr10:102295463 HIF1AN 0.69 6.6 0.38 2.19e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs7851660 0.967 rs10818133 chr9:100610348 C/G cg13688889 chr9:100608707 NA -0.68 -10.64 -0.55 3.08e-22 Strep throat; CESC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg18876405 chr7:65276391 NA -0.58 -7.55 -0.42 6.9e-13 Cotinine glucuronidation; CESC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg26335602 chr6:28129616 ZNF389 0.38 5.53 0.32 7.72e-8 Cardiac Troponin-T levels; CESC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg02725872 chr8:58115012 NA -0.36 -5.79 -0.34 1.99e-8 Developmental language disorder (linguistic errors); CESC trans rs1223629 1.000 rs56682281 chr10:95943954 A/T cg16346422 chr11:2920819 SLC22A18;SLC22A18AS 0.67 6.04 0.35 5.08e-9 Glucose homeostasis traits; CESC trans rs17307778 0.706 rs10767363 chr11:25358065 T/C cg22888484 chr20:37075185 SNHG11 -0.63 -6.07 -0.35 4.42e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg00149659 chr3:10157352 C3orf10 0.71 8.4 0.46 2.72e-15 Alzheimer's disease; CESC cis rs7959452 1.000 rs2168029 chr12:69734641 A/C cg14784868 chr12:69753453 YEATS4 0.56 7.54 0.42 7.52e-13 Blood protein levels; CESC cis rs637571 0.522 rs528736 chr11:65705108 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.46 6.0 0.35 6.47e-9 Eosinophil percentage of white cells; CESC cis rs3806843 1.000 rs11167609 chr5:140200426 T/G cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.11 -0.3 6.18e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9303401 0.614 rs34550282 chr17:57092788 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.9 11.27 0.57 2.59e-24 Cognitive test performance; CESC cis rs72627123 0.867 rs112464051 chr14:74483975 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.82 0.34 1.74e-8 Morning vs. evening chronotype; CESC cis rs4820539 1.000 rs4822358 chr22:23474795 A/G cg14186256 chr22:23484241 RTDR1 0.83 15.07 0.68 1.76e-37 Bone mineral density; CESC trans rs9467711 0.659 rs35680819 chr6:26455814 T/C cg06606381 chr12:133084897 FBRSL1 -0.94 -6.86 -0.39 4.96e-11 Autism spectrum disorder or schizophrenia; CESC cis rs28374715 0.532 rs28463309 chr15:41666716 A/G cg18705301 chr15:41695430 NDUFAF1 -1.01 -15.95 -0.7 1.34e-40 Ulcerative colitis; CESC cis rs1568889 0.774 rs11030235 chr11:28212375 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.23 0.63 5.11e-31 Bipolar disorder; CESC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg15147215 chr3:52552868 STAB1 0.33 5.58 0.32 5.93e-8 Electroencephalogram traits; CESC cis rs9616064 0.531 rs867212 chr22:47063330 C/T cg05621596 chr22:47072043 GRAMD4 0.7 10.35 0.54 2.62e-21 Urate levels in obese individuals; CESC cis rs7219451 0.655 rs8067028 chr17:38974029 G/A cg17985300 chr17:38952333 KRT28 -0.32 -5.31 -0.31 2.33e-7 Glucose homeostasis traits; CESC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg09323728 chr8:95962352 TP53INP1 -0.44 -10.09 -0.53 1.8e-20 Type 2 diabetes; CESC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg19468946 chr17:37922297 IKZF3 0.42 5.48 0.32 9.97e-8 Glomerular filtration rate (creatinine); CESC cis rs6456156 0.792 rs10946212 chr6:167515947 C/G cg07741184 chr6:167504864 NA 0.37 6.69 0.38 1.33e-10 Primary biliary cholangitis; CESC cis rs863345 0.967 rs12753013 chr1:158505221 T/A cg12129480 chr1:158549410 OR10X1 -0.31 -6.04 -0.35 5.32e-9 Pneumococcal bacteremia; CESC cis rs10463316 0.832 rs1019467 chr5:150734323 A/G cg03212797 chr5:150827313 SLC36A1 -0.52 -6.66 -0.38 1.58e-10 Metabolite levels (Pyroglutamine); CESC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1008375 0.933 rs10939757 chr4:17694125 T/C cg02297831 chr4:17616191 MED28 0.47 5.72 0.33 2.91e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04284535 chr17:41624145 ETV4 -0.44 -6.22 -0.36 1.94e-9 Gut microbiota (bacterial taxa); CESC cis rs8077577 0.747 rs11867895 chr17:18146721 A/C cg16794390 chr17:18148240 FLII 0.42 6.34 0.36 9.97e-10 Obesity-related traits; CESC cis rs7937682 0.632 rs11214037 chr11:111773296 C/T cg22437258 chr11:111473054 SIK2 -0.5 -5.55 -0.32 6.9e-8 Primary sclerosing cholangitis; CESC cis rs9902453 0.730 rs4583306 chr17:28538715 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -7.23 -0.41 5.27e-12 Coffee consumption (cups per day); CESC cis rs6088580 0.624 rs6120645 chr20:33025171 C/T cg08999081 chr20:33150536 PIGU 0.65 11.36 0.57 1.22e-24 Glomerular filtration rate (creatinine); CESC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg11890956 chr21:40555474 PSMG1 -0.97 -16.62 -0.71 5.65e-43 Cognitive function; CESC cis rs7223966 1.000 rs8075061 chr17:61804723 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.68 0.38 1.4e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7520050 0.966 rs4660317 chr1:46326226 G/A cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.4e-7 Red blood cell count;Reticulocyte count; CESC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg18904891 chr8:8559673 CLDN23 0.72 8.39 0.46 2.85e-15 Obesity-related traits; CESC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg09263875 chr16:632152 PIGQ 0.69 12.03 0.59 6.76e-27 Height; CESC cis rs2197308 0.765 rs11182900 chr12:37934009 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.81 0.39 6.71e-11 Morning vs. evening chronotype; CESC cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.72 10.01 0.52 3.23e-20 Eosinophil percentage of white cells; CESC cis rs1538970 0.739 rs4660863 chr1:45955868 T/C cg24296786 chr1:45957014 TESK2 -0.46 -5.15 -0.3 4.97e-7 Platelet count; CESC cis rs1348850 0.567 rs1405714 chr2:178538584 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.6 -7.99 -0.44 4.19e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.5 0.5 1.32e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs644148 0.679 rs2204119 chr19:44970975 T/C cg15540054 chr19:45004280 ZNF180 -0.6 -6.46 -0.37 4.86e-10 Personality dimensions; CESC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg04287289 chr16:89883240 FANCA -0.45 -5.55 -0.32 7.04e-8 Vitiligo; CESC cis rs4843747 0.749 rs12102841 chr16:88072574 C/G cg06374794 chr16:88002281 BANP -0.38 -5.18 -0.3 4.35e-7 Menopause (age at onset); CESC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg20151795 chr6:28129481 ZNF389 0.41 5.3 0.31 2.46e-7 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04699474 chr19:9945708 PIN1 0.5 6.1 0.35 3.69e-9 Gut microbiome composition (summer); CESC cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg16144293 chr14:75469539 EIF2B2 0.39 5.11 0.3 6.22e-7 Height; CESC cis rs7243790 0.807 rs13380938 chr18:51895547 T/C cg04730925 chr18:51795821 POLI -0.43 -5.74 -0.33 2.54e-8 Diastolic blood pressure; CESC cis rs10769945 0.679 rs7102920 chr11:1917872 C/T cg06679296 chr11:1949032 TNNT3 0.3 5.2 0.3 3.95e-7 DNA methylation (variation); CESC cis rs12477438 0.700 rs12467679 chr2:99654449 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs3780486 0.505 rs10813959 chr9:33166234 C/T cg13443165 chr9:33130375 B4GALT1 -0.48 -7.25 -0.41 4.52e-12 IgG glycosylation; CESC trans rs10493340 0.597 rs72674242 chr1:63598265 A/G cg01817204 chr3:123602957 MYLK -0.52 -6.63 -0.38 1.85e-10 Blood pressure; CESC cis rs916888 0.697 rs199516 chr17:44856485 C/T cg17911788 chr17:44343683 NA 0.55 7.51 0.42 8.84e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11190604 1.000 rs4919471 chr10:102299239 A/G cg07080220 chr10:102295463 HIF1AN 0.66 6.07 0.35 4.53e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs3892630 0.824 rs2287884 chr19:33321447 A/G cg22980127 chr19:33182716 NUDT19 1.04 11.73 0.58 7.44e-26 Red blood cell traits; CESC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -6.88 -0.39 4.4e-11 Developmental language disorder (linguistic errors); CESC cis rs1784581 0.802 rs6455787 chr6:162411378 G/A cg17173639 chr6:162384350 PARK2 0.61 9.44 0.5 2.05e-18 Itch intensity from mosquito bite; CESC cis rs2832191 0.633 rs2832166 chr21:30462395 G/C cg08807101 chr21:30365312 RNF160 0.88 12.54 0.61 1.26e-28 Dental caries; CESC cis rs2243480 1.000 rs781157 chr7:65478311 G/A cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.57e-15 Diabetic kidney disease; CESC cis rs1538970 0.816 rs4633317 chr1:45985157 T/C cg06784218 chr1:46089804 CCDC17 0.36 5.79 0.34 1.97e-8 Platelet count; CESC cis rs734999 0.549 rs6667564 chr1:2520302 T/C cg20673091 chr1:2541236 MMEL1 0.43 7.15 0.4 8.42e-12 Ulcerative colitis; CESC cis rs7208859 0.623 rs73269923 chr17:29102571 C/T cg19761014 chr17:28927070 LRRC37B2 0.79 6.28 0.36 1.37e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3026101 0.671 rs58832024 chr17:5306536 G/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00653609 chr6:39082964 C6orf64 -0.47 -6.17 -0.35 2.61e-9 Height; CESC cis rs7264396 0.561 rs6142470 chr20:34570579 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -6.98 -0.39 2.37e-11 Total cholesterol levels; CESC cis rs1375194 0.582 rs13388224 chr2:33802902 T/C cg04131969 chr2:33951647 MYADML -0.51 -6.51 -0.37 3.76e-10 Response to antidepressants in depression; CESC cis rs7666738 0.606 rs10006414 chr4:99101401 T/C cg05340658 chr4:99064831 C4orf37 0.64 8.59 0.47 7.58e-16 Colonoscopy-negative controls vs population controls; CESC cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg11812906 chr14:75593930 NEK9 0.9 15.15 0.68 9.31e-38 Height; CESC cis rs4481887 0.962 rs6686911 chr1:248476969 T/C cg00666640 chr1:248458726 OR2T12 0.41 6.56 0.37 2.84e-10 Common traits (Other); CESC cis rs7809950 0.953 rs2520267 chr7:107187497 T/C cg23024343 chr7:107201750 COG5 -0.41 -5.65 -0.33 4.03e-8 Coronary artery disease; CESC cis rs1153858 1.000 rs1890565 chr15:45663299 T/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg26338869 chr17:61819248 STRADA 0.69 9.13 0.49 1.8e-17 Prudent dietary pattern; CESC cis rs1316952 0.667 rs76411891 chr12:124388236 A/G cg12597309 chr12:124393772 DNAH10 0.35 5.21 0.3 3.77e-7 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs7872515 0.536 rs28883017 chr9:94774870 T/C cg01248375 chr9:94877805 SPTLC1 0.61 5.4 0.31 1.48e-7 Bipolar disorder and schizophrenia; CESC cis rs6772849 1.000 rs2713605 chr3:128307460 A/T cg16766828 chr3:128327626 NA -0.31 -5.06 -0.3 7.77e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg22875332 chr1:76189707 ACADM -0.54 -5.79 -0.34 1.94e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs939658 0.805 rs2010524 chr15:79435825 G/T cg17916960 chr15:79447300 NA -0.38 -6.3 -0.36 1.24e-9 Refractive error; CESC cis rs9611565 0.802 rs4822028 chr22:41789408 A/G cg17376030 chr22:41985996 PMM1 0.52 5.74 0.33 2.62e-8 Vitiligo; CESC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg06481639 chr22:41940642 POLR3H 0.52 5.68 0.33 3.48e-8 Vitiligo; CESC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg24060327 chr5:131705240 SLC22A5 0.4 5.16 0.3 4.74e-7 Breast cancer; CESC cis rs4566357 0.615 rs10177528 chr2:227913706 G/A cg05526886 chr2:227700861 RHBDD1 -0.47 -6.27 -0.36 1.45e-9 Coronary artery disease; CESC cis rs1559088 0.948 rs10406916 chr19:33590093 G/A cg27124370 chr19:33622961 WDR88 0.45 6.0 0.35 6.49e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9811920 0.609 rs9872871 chr3:99658702 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.57 -6.84 -0.39 5.62e-11 Axial length; CESC cis rs66887589 0.720 rs11724758 chr4:120239878 G/A cg09307838 chr4:120376055 NA 0.57 7.68 0.43 3.06e-13 Diastolic blood pressure; CESC cis rs6691722 0.503 rs3765428 chr1:24706113 G/A cg18323236 chr1:24743029 NIPAL3 0.37 5.61 0.33 5.09e-8 Response to interferon beta in multiple sclerosis; CESC cis rs6504950 0.566 rs7208403 chr17:53046667 C/A cg19360675 chr17:53046073 COX11;STXBP4 0.43 5.53 0.32 7.75e-8 Breast cancer; CESC cis rs7107174 1.000 rs58565853 chr11:78036707 C/T cg02023728 chr11:77925099 USP35 0.45 6.35 0.36 9.35e-10 Testicular germ cell tumor; CESC cis rs7474896 0.583 rs11011347 chr10:38019264 G/A cg25427524 chr10:38739819 LOC399744 -0.49 -5.57 -0.32 6.36e-8 Obesity (extreme); CESC cis rs7714584 1.000 rs1000113 chr5:150240076 C/T cg22134413 chr5:150180641 NA 0.56 5.71 0.33 2.98e-8 Crohn's disease; CESC cis rs10751667 0.580 rs7395515 chr11:1005160 C/T cg20946044 chr11:1010712 AP2A2 -0.51 -6.88 -0.39 4.29e-11 Alzheimer's disease (late onset); CESC cis rs4906332 0.811 rs2296487 chr14:103996205 T/C cg19000871 chr14:103996768 TRMT61A -0.35 -5.04 -0.3 8.56e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15338675 chr6:28193028 ZNF193 0.66 7.43 0.42 1.46e-12 Gut microbiome composition (summer); CESC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg23048001 chr7:2026167 MAD1L1 0.4 5.14 0.3 5.34e-7 Bipolar disorder and schizophrenia; CESC cis rs5753037 0.702 rs131301 chr22:30185889 A/T cg01021169 chr22:30184971 ASCC2 -0.47 -6.68 -0.38 1.37e-10 Type 1 diabetes; CESC trans rs12599106 0.707 rs2163977 chr16:34916134 A/G cg01516881 chr6:292596 DUSP22 -0.79 -10.32 -0.54 3.34e-21 Menopause (age at onset); CESC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg25204440 chr1:209979598 IRF6 -0.59 -6.36 -0.36 8.87e-10 Cleft lip with or without cleft palate; CESC cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.34 0.31 2.01e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg00166722 chr3:10149974 C3orf24 0.49 6.04 0.35 5.3e-9 Alzheimer's disease; CESC cis rs2304069 0.909 rs30831 chr5:149359053 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.9 -10.84 -0.55 6.61e-23 HIV-1 control; CESC cis rs7589342 0.894 rs6736932 chr2:106444854 A/G cg16077055 chr2:106428750 NCK2 0.49 6.93 0.39 3.11e-11 Addiction; CESC cis rs6088580 0.634 rs6059856 chr20:33057954 G/C cg24642439 chr20:33292090 TP53INP2 0.52 6.87 0.39 4.68e-11 Glomerular filtration rate (creatinine); CESC cis rs12822507 0.868 rs61915599 chr12:12768409 A/G cg09462578 chr12:12878428 APOLD1 -0.43 -5.32 -0.31 2.19e-7 Systemic lupus erythematosus; CESC cis rs7586673 0.857 rs16845580 chr2:161920884 T/C cg22496339 chr2:162101262 NA 0.51 6.77 0.38 8.09e-11 Intelligence (multi-trait analysis); CESC cis rs6121246 0.529 rs6060142 chr20:30178028 A/G cg13852791 chr20:30311386 BCL2L1 0.67 6.77 0.38 8.03e-11 Mean corpuscular hemoglobin; CESC cis rs7412746 0.611 rs11204747 chr1:150927152 A/G cg04414720 chr1:150670196 GOLPH3L -0.44 -6.04 -0.35 5.25e-9 Melanoma; CESC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 13.52 0.64 5.02e-32 Platelet count; CESC cis rs3845702 0.736 rs9288045 chr2:180814194 G/A cg01881094 chr2:180872142 CWC22 -1.05 -9.21 -0.49 9.96e-18 Schizophrenia; CESC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg11644478 chr21:40555479 PSMG1 1.04 17.85 0.74 2.41e-47 Cognitive function; CESC cis rs4481887 0.610 rs28763387 chr1:248559244 T/C cg26353448 chr1:248524236 OR2T4 -0.37 -5.14 -0.3 5.42e-7 Common traits (Other); CESC cis rs9788682 0.747 rs28480606 chr15:78762313 A/G cg24631222 chr15:78858424 CHRNA5 0.61 7.16 0.4 8.13e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs1178968 1.000 rs13240408 chr7:72758023 T/C cg25889504 chr7:72793014 NA 0.48 5.08 0.3 7.22e-7 Triglyceride levels; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg23666278 chr2:171785822 GORASP2 -0.41 -6.1 -0.35 3.8e-9 Breast cancer; CESC cis rs2243480 0.711 rs2460426 chr7:65623129 A/G cg12463550 chr7:65579703 CRCP -0.73 -5.71 -0.33 3.1e-8 Diabetic kidney disease; CESC cis rs863345 0.967 rs7520063 chr1:158470198 T/C cg12129480 chr1:158549410 OR10X1 -0.31 -6.2 -0.36 2.14e-9 Pneumococcal bacteremia; CESC cis rs754466 0.580 rs10430530 chr10:79582812 T/C cg17075019 chr10:79541650 NA -0.88 -14.01 -0.65 9.69e-34 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7188697 0.922 rs28307 chr16:58577138 A/C cg21335942 chr16:58549945 SETD6 0.45 5.33 0.31 2.13e-7 QT interval; CESC cis rs7129220 0.588 rs7931957 chr11:10094304 G/A cg01453529 chr11:10209919 SBF2 -0.47 -5.31 -0.31 2.32e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs9457247 0.967 rs2149083 chr6:167370971 G/C cg07741184 chr6:167504864 NA -0.3 -5.25 -0.31 3.1e-7 Crohn's disease; CESC cis rs709400 0.663 rs28444993 chr14:103930564 T/C cg12935359 chr14:103987150 CKB -0.51 -7.42 -0.41 1.57e-12 Body mass index; CESC cis rs17826219 0.568 rs11658027 chr17:29094882 A/G cg19761014 chr17:28927070 LRRC37B2 -0.75 -6.23 -0.36 1.87e-9 Body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26904991 chr16:8891722 PMM2;TMEM186 -0.41 -6.11 -0.35 3.47e-9 Gambling; CESC cis rs790123 1.000 rs790123 chr3:122388993 T/C cg17380795 chr3:122379686 NA 0.38 5.58 0.32 5.8e-8 Response to angiotensin II receptor blocker therapy; CESC cis rs3820928 1.000 rs12615988 chr2:227769000 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -5.66 -0.33 3.83e-8 Pulmonary function; CESC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg07256732 chr16:621771 PIGQ -0.31 -5.35 -0.31 1.91e-7 Height; CESC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg26338869 chr17:61819248 STRADA 0.71 9.47 0.5 1.6e-18 Prudent dietary pattern; CESC cis rs2354432 0.505 rs3737845 chr1:146724408 A/G cg25205988 chr1:146714368 CHD1L 0.99 8.27 0.45 6.59e-15 Mitochondrial DNA levels; CESC trans rs4349753 0.640 rs10041987 chr5:144084954 G/A cg22407458 chr6:35109121 TCP11 0.5 6.31 0.36 1.18e-9 Photic sneeze reflex; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06812225 chr1:204485782 MDM4 0.66 8.04 0.44 3.03e-14 Gut microbiome composition (summer); CESC cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg19626725 chr5:178986131 RUFY1 0.35 5.17 0.3 4.57e-7 Lung cancer; CESC cis rs4919687 0.550 rs12784517 chr10:104464970 T/C cg04362960 chr10:104952993 NT5C2 0.46 5.37 0.31 1.73e-7 Colorectal cancer; CESC cis rs8067545 1.000 rs9891739 chr17:19942177 C/T cg13482628 chr17:19912719 NA 0.43 5.78 0.33 2.08e-8 Schizophrenia; CESC cis rs2710642 0.721 rs10177638 chr2:62887010 C/T cg17519650 chr2:63277830 OTX1 0.49 6.19 0.36 2.27e-9 LDL cholesterol levels;LDL cholesterol; CESC cis rs6460942 0.597 rs13221702 chr7:12519076 A/G cg10578991 chr7:12443926 VWDE 0.49 5.19 0.3 4.16e-7 Coronary artery disease; CESC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg06456125 chr7:65229604 NA 0.39 5.08 0.3 7.17e-7 Aortic root size; CESC cis rs9908102 0.653 rs8071829 chr17:12914517 G/A cg26162695 chr17:12921313 ELAC2 0.51 5.47 0.32 1.03e-7 Schizophrenia; CESC cis rs4704187 0.687 rs9293642 chr5:74365026 C/T cg03227963 chr5:74354835 NA 0.31 5.82 0.34 1.66e-8 Response to amphetamines; CESC cis rs830124 0.602 rs1630699 chr12:122386758 G/C cg22168489 chr12:122356033 WDR66 -0.38 -5.05 -0.3 8.27e-7 Urinary metabolites; CESC cis rs9972944 0.534 rs7208926 chr17:63863210 G/A cg07283582 chr17:63770753 CCDC46 -0.34 -5.03 -0.3 9.04e-7 Total body bone mineral density; CESC cis rs6546550 0.867 rs6738174 chr2:70150215 A/C cg02498382 chr2:70120550 SNRNP27 -0.41 -7.26 -0.41 4.34e-12 Prevalent atrial fibrillation; CESC cis rs61776719 0.500 rs11210866 chr1:38449565 T/C cg04673462 chr1:38461896 NA 0.39 6.0 0.35 6.5e-9 Coronary artery disease; CESC cis rs78889164 0.876 rs17570 chr19:33878837 G/A cg02272751 chr19:33882848 PEPD -0.57 -8.35 -0.46 3.73e-15 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg11764359 chr7:65958608 NA 0.79 9.51 0.5 1.18e-18 Aortic root size; CESC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg07701084 chr6:150067640 NUP43 0.4 5.48 0.32 9.87e-8 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07114478 chr16:3033714 NA 0.55 6.25 0.36 1.63e-9 Gut microbiome composition (summer); CESC cis rs142802669 1 rs142802669 chr3:41869427 A/C cg03022575 chr3:42003672 ULK4 0.48 5.51 0.32 8.52e-8 Immunoglobulin light chain (AL) amyloidosis; CESC cis rs796364 0.906 rs281766 chr2:200820505 T/G cg23649088 chr2:200775458 C2orf69 0.55 5.33 0.31 2.14e-7 Schizophrenia; CESC cis rs6973256 0.568 rs7800126 chr7:133521356 A/C cg10665199 chr7:133106180 EXOC4 0.44 6.14 0.35 3.04e-9 Intelligence (multi-trait analysis); CESC trans rs208520 0.690 rs207081 chr6:66773742 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -12.55 -0.61 1.16e-28 Exhaled nitric oxide output; CESC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.79 0.52 1.65e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs9908102 0.740 rs58985615 chr17:12909988 C/A cg26162695 chr17:12921313 ELAC2 0.52 5.67 0.33 3.77e-8 Schizophrenia; CESC cis rs36051895 0.632 rs1360063 chr9:5167649 A/G cg02405213 chr9:5042618 JAK2 -0.53 -6.14 -0.35 3.08e-9 Pediatric autoimmune diseases; CESC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.17e-12 Tonsillectomy; CESC trans rs17508449 0.819 rs77892281 chr1:114163617 A/T cg15464363 chr22:32149800 DEPDC5 -0.68 -6.14 -0.35 3.03e-9 Leprosy; CESC cis rs1003719 0.680 rs2835630 chr21:38521842 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.0 -0.44 4.01e-14 Eye color traits; CESC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg04267008 chr7:1944627 MAD1L1 -0.59 -7.18 -0.4 6.96e-12 Bipolar disorder and schizophrenia; CESC cis rs2281558 0.876 rs2274890 chr20:25301022 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.61 8.17 0.45 1.31e-14 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs826838 1.000 rs11183747 chr12:38822595 A/G cg13010199 chr12:38710504 ALG10B -0.61 -8.63 -0.47 5.66e-16 Heart rate; CESC cis rs10744422 1.000 rs2292134 chr12:123334033 C/G cg25930673 chr12:123319894 HIP1R -0.72 -5.73 -0.33 2.79e-8 Schizophrenia; CESC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg04025307 chr7:1156635 C7orf50 0.48 7.52 0.42 8.34e-13 Longevity;Endometriosis; CESC cis rs5771242 0.769 rs4838865 chr22:50664612 A/G cg16473166 chr22:50639996 SELO 0.78 8.9 0.48 8.73e-17 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC cis rs10754283 0.967 rs6698273 chr1:90106791 T/A cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7264396 0.563 rs17093093 chr20:34380925 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -9.7 -0.51 3.12e-19 Total cholesterol levels; CESC cis rs3733585 0.783 rs13148371 chr4:10032561 C/T cg11266682 chr4:10021025 SLC2A9 0.71 14.13 0.66 3.57e-34 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg26335602 chr6:28129616 ZNF389 0.48 6.14 0.35 3.05e-9 Parkinson's disease; CESC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg22143856 chr6:28129313 ZNF389 0.43 5.67 0.33 3.79e-8 Depression; CESC cis rs9796 0.689 rs13329537 chr15:41449211 C/G cg20272979 chr15:41787780 ITPKA -0.33 -5.09 -0.3 6.75e-7 Menopause (age at onset); CESC cis rs8016982 0.630 rs61980900 chr14:81686436 T/C cg01989461 chr14:81687754 GTF2A1 0.75 11.71 0.58 8.36e-26 Schizophrenia; CESC cis rs3733585 0.806 rs11723382 chr4:9954660 T/C cg02734326 chr4:10020555 SLC2A9 -0.45 -6.82 -0.39 6.28e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11690935 0.959 rs7604918 chr2:172588094 G/A cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.97 -0.68 4e-37 Schizophrenia; CESC cis rs7666738 0.830 rs28818218 chr4:98880575 A/C cg17366294 chr4:99064904 C4orf37 0.56 7.87 0.44 9.04e-14 Colonoscopy-negative controls vs population controls; CESC cis rs2294693 0.898 rs6458195 chr6:40972498 A/T cg14769373 chr6:40998127 UNC5CL 0.42 5.67 0.33 3.66e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs9457247 1.000 rs385863 chr6:167386615 C/G cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs2479106 0.892 rs12347057 chr9:126694094 T/A cg16191174 chr9:126692580 DENND1A 0.51 7.0 0.4 2.04e-11 Polycystic ovary syndrome; CESC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -8.14 -0.45 1.5e-14 Gut microbiome composition (summer); CESC cis rs7520050 1.000 rs7540699 chr1:46338585 A/G cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.4e-7 Red blood cell count;Reticulocyte count; CESC trans rs61931739 0.500 rs34997501 chr12:34549828 C/G cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15262992 chr20:61442882 OGFR -0.59 -6.85 -0.39 5.27e-11 Gut microbiome composition (summer); CESC cis rs4853012 1.000 rs2280643 chr2:74358286 T/C cg05890377 chr2:74357713 NA 0.71 8.95 0.48 6.36e-17 Gestational age at birth (maternal effect); CESC cis rs60154123 0.730 rs590380 chr1:210463071 C/T cg21951975 chr1:209979733 IRF6 0.42 5.46 0.32 1.09e-7 Coronary artery disease; CESC trans rs7615952 0.932 rs9841157 chr3:125635655 C/A cg07211511 chr3:129823064 LOC729375 -1.1 -13.63 -0.64 2.03e-32 Blood pressure (smoking interaction); CESC cis rs9325144 0.560 rs11182979 chr12:38642562 C/A cg26384229 chr12:38710491 ALG10B -0.61 -8.58 -0.47 8.35e-16 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs7697315 chr4:98938764 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.2 0.45 1.07e-14 Colonoscopy-negative controls vs population controls; CESC cis rs6977955 1.000 rs2189965 chr7:28172014 C/T cg23620719 chr7:28220237 JAZF1 0.58 6.67 0.38 1.45e-10 Allergic disease (asthma, hay fever or eczema); CESC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg06453172 chr10:134556979 INPP5A -0.41 -5.29 -0.31 2.54e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg24768116 chr2:27665128 KRTCAP3 -0.31 -5.8 -0.34 1.88e-8 Total body bone mineral density; CESC cis rs9814567 0.806 rs11927540 chr3:134319455 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.39 -5.11 -0.3 6.3e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs1382269 0.840 rs1478326 chr3:136964960 G/A cg16900796 chr19:10755136 SLC44A2 -0.4 -6.15 -0.35 2.82e-9 Metabolite levels; CESC cis rs4704187 0.640 rs74719230 chr5:74431888 G/C cg03227963 chr5:74354835 NA 0.3 5.57 0.32 6.41e-8 Response to amphetamines; CESC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.64 -7.14 -0.4 9.1e-12 Gut microbiome composition (summer); CESC cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg23583168 chr7:148888333 NA -0.72 -10.06 -0.53 2.29e-20 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg22467129 chr15:76604101 ETFA -0.37 -5.64 -0.33 4.44e-8 Blood metabolite levels; CESC cis rs12410462 0.582 rs2872251 chr1:227647723 G/A cg23173402 chr1:227635558 NA 0.55 5.41 0.32 1.41e-7 Major depressive disorder; CESC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC trans rs7618501 0.521 rs11130222 chr3:49901060 A/T cg21659725 chr3:3221576 CRBN 0.47 6.19 0.36 2.26e-9 Intelligence (multi-trait analysis); CESC cis rs9790314 0.967 rs336541 chr3:161056698 A/C cg03342759 chr3:160939853 NMD3 -0.47 -6.07 -0.35 4.48e-9 Morning vs. evening chronotype; CESC cis rs73206853 0.563 rs7301623 chr12:111170903 T/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.7 0.33 3.23e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs7937682 0.924 rs7924683 chr11:111555796 C/A cg18187862 chr3:45730750 SACM1L 0.51 6.58 0.37 2.49e-10 Primary sclerosing cholangitis; CESC cis rs9863 0.861 rs7973683 chr12:124449223 C/A cg00084347 chr12:124393913 DNAH10 0.27 5.3 0.31 2.46e-7 White blood cell count; CESC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg22903471 chr2:27725779 GCKR -0.53 -7.5 -0.42 9.45e-13 Total body bone mineral density; CESC cis rs7762018 0.769 rs7766146 chr6:170070135 A/T cg05834625 chr6:170176447 C6orf70 0.52 5.64 0.33 4.31e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6662572 0.641 rs4660891 chr1:46319447 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.04 -0.3 8.65e-7 Blood protein levels; CESC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.58 0.37 2.53e-10 Electroencephalogram traits; CESC cis rs72901758 0.768 rs72901766 chr17:76245203 G/C cg23302638 chr17:76210176 BIRC5 0.5 5.56 0.32 6.7e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs1008375 0.866 rs2109518 chr4:17572162 G/A cg27347728 chr4:17578864 LAP3 0.43 5.14 0.3 5.22e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg27572855 chr1:25598939 RHD -0.44 -7.42 -0.41 1.63e-12 Erythrocyte sedimentation rate; CESC cis rs5753037 0.585 rs36572 chr22:30200936 T/C cg01021169 chr22:30184971 ASCC2 -0.55 -8.34 -0.46 4.1e-15 Type 1 diabetes; CESC cis rs9303280 0.806 rs11078928 chr17:38064469 T/C cg20243544 chr17:37824526 PNMT 0.53 6.79 0.39 7.3e-11 Self-reported allergy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01932459 chr6:109703513 CD164 0.59 6.85 0.39 5.1e-11 Gut microbiome composition (summer); CESC trans rs1908814 0.516 rs13275143 chr8:11796990 T/A cg15556689 chr8:8085844 FLJ10661 0.53 6.56 0.37 2.88e-10 Neuroticism; CESC cis rs367943 0.672 rs1517207 chr5:112717245 G/A cg12552261 chr5:112820674 MCC 0.39 5.22 0.31 3.62e-7 Type 2 diabetes; CESC cis rs6032067 1.000 rs34885285 chr20:43804789 C/A cg10761708 chr20:43804764 PI3 0.53 6.33 0.36 1.04e-9 Blood protein levels; CESC cis rs6024905 0.722 rs2275954 chr20:36962667 C/T cg07053727 chr20:36965646 BPI -0.49 -7.35 -0.41 2.49e-12 Bipolar disorder and schizophrenia; CESC cis rs67311347 0.866 rs3214006 chr3:40352134 C/T cg09455208 chr3:40491958 NA 0.46 7.61 0.42 4.93e-13 Renal cell carcinoma; CESC cis rs1949733 1.000 rs1357481 chr4:8496221 A/T cg11789530 chr4:8429930 ACOX3 0.7 10.08 0.53 1.91e-20 Response to antineoplastic agents; CESC cis rs11690935 0.959 rs1113389 chr2:172635365 C/T cg13550731 chr2:172543902 DYNC1I2 -1.01 -16.63 -0.71 5.07e-43 Schizophrenia; CESC cis rs13082711 0.863 rs35998108 chr3:27423427 G/A cg02860705 chr3:27208620 NA 0.54 6.82 0.39 6.15e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs6912958 0.559 rs107690 chr6:88069352 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -8.56 -0.47 9.42e-16 Monocyte percentage of white cells; CESC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.71 0.58 8.58e-26 Alzheimer's disease; CESC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg21285383 chr16:89894308 SPIRE2 0.33 5.98 0.35 7.03e-9 Vitiligo; CESC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg00745463 chr17:30367425 LRRC37B -0.53 -5.37 -0.31 1.76e-7 Hip circumference adjusted for BMI; CESC cis rs6963495 0.818 rs6961233 chr7:105150469 C/T cg02135003 chr7:105160482 PUS7 -0.47 -5.61 -0.33 5.12e-8 Bipolar disorder (body mass index interaction); CESC cis rs763014 0.931 rs59476302 chr16:629006 C/T cg00802000 chr16:706648 WDR90 -0.42 -6.41 -0.37 6.52e-10 Height; CESC cis rs4664308 0.618 rs17830755 chr2:160888835 T/C cg03641300 chr2:160917029 PLA2R1 -0.59 -8.54 -0.46 1.04e-15 Idiopathic membranous nephropathy; CESC trans rs877282 0.685 rs56234340 chr10:781339 A/G cg22713356 chr15:30763199 NA 0.97 10.16 0.53 1.09e-20 Uric acid levels; CESC cis rs7208859 0.623 rs8067338 chr17:29102345 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2070433 0.500 rs9306156 chr21:47960493 T/C cg12379764 chr21:47803548 PCNT 0.56 7.45 0.42 1.29e-12 Lymphocyte counts; CESC cis rs4555082 0.957 rs2816628 chr14:105736134 T/G cg27165867 chr14:105738592 BRF1 -0.48 -5.85 -0.34 1.47e-8 Mean platelet volume;Platelet distribution width; CESC cis rs4919694 1.000 rs11191439 chr10:104638723 C/T cg04362960 chr10:104952993 NT5C2 -0.75 -6.34 -0.36 9.85e-10 Arsenic metabolism; CESC cis rs300703 0.654 rs435733 chr2:121222 A/G cg21211680 chr2:198530 NA -0.96 -9.78 -0.52 1.7e-19 Blood protein levels; CESC cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg03060546 chr3:49711283 APEH -0.56 -6.38 -0.36 8.03e-10 Parkinson's disease; CESC trans rs11098499 0.954 rs35063680 chr4:120387102 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.93 0.52 5.63e-20 Corneal astigmatism; CESC cis rs7772486 0.686 rs6933161 chr6:146081369 G/A cg23711669 chr6:146136114 FBXO30 -0.88 -13.18 -0.63 7.63e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs7091068 0.536 rs6583901 chr10:95409998 C/T cg20715218 chr10:95462985 C10orf4 -0.48 -5.78 -0.33 2.14e-8 Urinary tract infection frequency; CESC trans rs10242455 0.702 rs7794068 chr7:99146873 A/T cg09045935 chr12:6379348 NA 0.83 7.11 0.4 1.08e-11 Blood metabolite levels; CESC cis rs2236521 0.659 rs72487383 chr20:60889313 A/C cg12382846 chr20:60892121 LAMA5 0.35 6.34 0.36 9.86e-10 Pelvic organ prolapse; CESC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg14893161 chr1:205819251 PM20D1 -0.45 -6.18 -0.35 2.4e-9 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs2243480 1.000 rs465359 chr7:65558164 C/T cg13147721 chr7:65941812 NA -0.98 -9.11 -0.49 2.06e-17 Diabetic kidney disease; CESC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg25072359 chr17:41440525 NA 0.48 6.46 0.37 4.98e-10 Menopause (age at onset); CESC cis rs17376456 0.877 rs17315943 chr5:93442830 T/C cg21475434 chr5:93447410 FAM172A 0.85 7.6 0.42 5.01e-13 Diabetic retinopathy; CESC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.93e-7 Lung cancer; CESC cis rs4843747 0.636 rs11117358 chr16:88105053 T/A cg03395651 chr16:88107091 BANP 0.46 5.34 0.31 1.98e-7 Menopause (age at onset); CESC cis rs11203032 0.831 rs11203017 chr10:90948709 C/T cg16672925 chr10:90967113 CH25H 0.72 7.16 0.4 7.78e-12 Heart failure; CESC cis rs17826219 0.636 rs4055314 chr17:29079769 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.51 0.37 3.84e-10 Body mass index; CESC trans rs7246657 0.943 rs7248733 chr19:37996361 A/C cg24637308 chr11:6592297 DNHD1 0.52 6.32 0.36 1.12e-9 Coronary artery calcification; CESC cis rs751728 1.000 rs755496 chr6:33734376 C/G cg25922239 chr6:33757077 LEMD2 0.5 6.73 0.38 1.05e-10 Crohn's disease; CESC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg22800045 chr5:56110881 MAP3K1 -0.55 -7.15 -0.4 8.45e-12 Initial pursuit acceleration; CESC cis rs5758659 0.714 rs5758589 chr22:42518382 A/G cg04733989 chr22:42467013 NAGA -0.45 -6.23 -0.36 1.83e-9 Cognitive function; CESC cis rs9837602 0.938 rs9815439 chr3:99785206 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 6.79 0.38 7.54e-11 Breast cancer; CESC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.71 0.62 3.31e-29 Gut microbiome composition (summer); CESC cis rs8067354 0.574 rs2526353 chr17:57988607 G/T cg13753209 chr17:57696993 CLTC 0.54 5.69 0.33 3.36e-8 Hemoglobin concentration; CESC cis rs7191439 0.722 rs6500491 chr16:88783521 T/C cg02389323 chr16:88786976 FAM38A 0.85 6.44 0.37 5.49e-10 Plateletcrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22060484 chr11:64646415 EHD1 0.58 6.79 0.38 7.5e-11 Gut microbiome composition (summer); CESC cis rs2262909 0.962 rs73019844 chr19:22249925 T/C cg11619707 chr19:22235551 ZNF257 0.33 5.17 0.3 4.65e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs3780486 0.505 rs10117038 chr9:33122626 T/C cg13443165 chr9:33130375 B4GALT1 0.46 7.08 0.4 1.27e-11 IgG glycosylation; CESC cis rs2952156 0.959 rs907087 chr17:37828787 G/A cg07936489 chr17:37558343 FBXL20 -0.54 -6.4 -0.37 7.14e-10 Asthma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06538771 chr22:50636937 TRABD 0.48 7.05 0.4 1.56e-11 Fibrinogen levels; CESC trans rs12310956 0.532 rs6488186 chr12:33974122 G/A cg26384229 chr12:38710491 ALG10B 0.5 6.82 0.39 5.98e-11 Morning vs. evening chronotype; CESC cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg26597838 chr10:835615 NA 0.64 6.02 0.35 5.75e-9 Eosinophil percentage of granulocytes; CESC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg11814155 chr7:99998594 ZCWPW1 0.53 5.14 0.3 5.31e-7 Platelet count; CESC cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg02773041 chr1:40204384 PPIE 0.53 7.56 0.42 6.49e-13 Blood protein levels; CESC cis rs116095464 0.558 rs10056628 chr5:279512 G/A cg22496380 chr5:211416 CCDC127 -0.99 -10.21 -0.53 7.52e-21 Breast cancer; CESC cis rs4888262 0.545 rs7342732 chr16:74698716 A/C cg01733217 chr16:74700730 RFWD3 0.91 12.9 0.62 7.31e-30 Testicular germ cell tumor; CESC cis rs6963495 0.519 rs3892297 chr7:105152173 G/A cg13798780 chr7:105162888 PUS7 0.75 7.67 0.43 3.27e-13 Bipolar disorder (body mass index interaction); CESC cis rs7590720 1.000 rs934154 chr2:216901933 C/T cg12620499 chr2:216877984 MREG 0.9 12.27 0.6 1.02e-27 Alcohol dependence; CESC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg23281280 chr6:28129359 ZNF389 0.37 5.47 0.32 1.06e-7 Parkinson's disease; CESC cis rs67311347 0.868 rs10865895 chr3:40378677 C/T cg24209194 chr3:40518798 ZNF619 0.4 5.1 0.3 6.35e-7 Renal cell carcinoma; CESC cis rs17125944 0.686 rs12435704 chr14:53346574 T/C cg00686598 chr14:53173677 PSMC6 -0.64 -5.58 -0.32 6.08e-8 Alzheimer's disease (late onset); CESC cis rs9911578 0.935 rs304261 chr17:56813782 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.88 -0.39 4.25e-11 Intelligence (multi-trait analysis); CESC cis rs11122272 0.735 rs2808601 chr1:231536571 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -6.59 -0.38 2.31e-10 Hemoglobin concentration; CESC cis rs2180341 0.960 rs9398842 chr6:127674662 T/C cg27446573 chr6:127587934 RNF146 1.06 15.88 0.7 2.39e-40 Breast cancer; CESC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg04772025 chr11:68637568 NA 0.5 6.14 0.35 2.92e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08302209 chr14:92506076 TRIP11 0.48 6.09 0.35 3.96e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg07636037 chr3:49044803 WDR6 -0.56 -8.0 -0.44 3.89e-14 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07483432 chr12:72079704 TMEM19 -0.54 -6.22 -0.36 1.94e-9 Gut microbiome composition (summer); CESC cis rs10510921 0.826 rs9825384 chr3:64893104 A/C cg13520011 chr3:65339606 NA -0.54 -5.23 -0.31 3.4e-7 Clozapine-induced agranulocytosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02661095 chr16:1869158 HAGH 0.46 6.57 0.37 2.66e-10 Fibrinogen levels; CESC cis rs2637266 0.667 rs7091526 chr10:78319770 A/G cg18941641 chr10:78392320 NA -0.31 -5.19 -0.3 4.14e-7 Pulmonary function; CESC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg06484146 chr7:12443880 VWDE -0.78 -9.1 -0.49 2.28e-17 Coronary artery disease; CESC cis rs7143963 0.609 rs4906270 chr14:103364737 G/T cg24154132 chr14:103367632 TRAF3 0.34 6.06 0.35 4.68e-9 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18029778 chr7:104654746 MLL5;LOC100216545 0.65 7.63 0.42 4.26e-13 Gut microbiome composition (summer); CESC cis rs1322639 0.614 rs6940913 chr6:169563666 G/A cg04662567 chr6:169592167 NA -0.49 -5.19 -0.3 4.2e-7 Pulse pressure; CESC cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg18225595 chr11:63971243 STIP1 0.51 6.7 0.38 1.24e-10 Platelet count; CESC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg17427002 chr7:12443146 VWDE -0.56 -5.85 -0.34 1.42e-8 Coronary artery disease; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg01095510 chr12:26267286 NA 0.47 6.01 0.35 6.01e-9 Psoriatic arthritis; CESC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg04166393 chr7:2884313 GNA12 0.59 7.7 0.43 2.77e-13 Height; CESC cis rs9633740 0.545 rs2343306 chr10:82230146 A/G cg00277334 chr10:82204260 NA 0.6 6.08 0.35 4.06e-9 Post bronchodilator FEV1; CESC cis rs250677 0.522 rs6875902 chr5:148407893 C/A cg18129178 chr5:148520854 ABLIM3 -0.45 -5.06 -0.3 7.92e-7 Breast cancer; CESC cis rs10911232 0.507 rs4442336 chr1:182982538 T/G ch.1.3577855R chr1:183094577 LAMC1 0.83 13.25 0.63 4.4e-31 Hypertriglyceridemia; CESC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg25072359 chr17:41440525 NA 0.44 5.85 0.34 1.43e-8 Menopause (age at onset); CESC trans rs11098499 0.863 rs1155576 chr4:120450159 A/C cg25214090 chr10:38739885 LOC399744 0.71 9.8 0.52 1.46e-19 Corneal astigmatism; CESC trans rs116095464 0.558 rs7710005 chr5:233572 A/G cg00938859 chr5:1591904 SDHAP3 0.66 7.18 0.4 6.97e-12 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13411962 chr8:28243934 ZNF395 -0.45 -6.04 -0.35 5.27e-9 Ulcerative colitis; CESC cis rs2635047 0.713 rs17723389 chr18:44762307 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.64 0.33 4.37e-8 Educational attainment; CESC cis rs473651 0.904 rs472247 chr2:239362573 G/A cg21699342 chr2:239360505 ASB1 0.56 9.48 0.5 1.52e-18 Multiple system atrophy; CESC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06096824 chr1:51443952 NA -0.48 -6.22 -0.36 1.94e-9 Fibrinogen levels; CESC cis rs208520 1.000 rs72882086 chr6:66976671 G/A cg07460842 chr6:66804631 NA 0.88 10.2 0.53 7.81e-21 Exhaled nitric oxide output; CESC cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.89 0.48 9.9900000000000006e-17 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg17366294 chr4:99064904 C4orf37 0.56 7.79 0.43 1.48e-13 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04400940 chr3:150329548 SELT -0.75 -8.46 -0.46 1.84e-15 Gut microbiome composition (summer); CESC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg21770322 chr7:97807741 LMTK2 0.54 8.15 0.45 1.45e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs2456568 0.548 rs7117597 chr11:93655091 A/G cg26875233 chr11:93583750 C11orf90 -0.34 -5.89 -0.34 1.16e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs7107174 1.000 rs7116698 chr11:77995191 T/C cg02023728 chr11:77925099 USP35 0.48 6.68 0.38 1.41e-10 Testicular germ cell tumor; CESC cis rs644799 1.000 rs514170 chr11:95556696 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.57e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.92 10.75 0.55 1.32e-22 Platelet count; CESC cis rs1881797 1.000 rs1881796 chr1:247688931 G/A cg05639522 chr1:247681581 NA 0.45 5.99 0.35 6.71e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg23758822 chr17:41437982 NA 1.05 16.33 0.71 5.75e-42 Menopause (age at onset); CESC cis rs4969178 0.965 rs2292643 chr17:76395421 G/A cg05887092 chr17:76393375 PGS1 0.58 9.14 0.49 1.64e-17 HDL cholesterol levels; CESC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg25767906 chr1:53392781 SCP2 -0.43 -5.47 -0.32 1.04e-7 Monocyte count; CESC cis rs9486715 0.867 rs12207471 chr6:96963782 A/G cg18709589 chr6:96969512 KIAA0776 0.44 6.18 0.35 2.4e-9 Headache; CESC cis rs9929218 0.911 rs4783685 chr16:68834107 C/T cg02972257 chr16:68554789 NA 0.51 5.85 0.34 1.43e-8 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27435660 chr10:5935953 FBXO18 -0.54 -6.5 -0.37 4.06e-10 Gut microbiome composition (summer); CESC cis rs2204008 0.744 rs1115514 chr12:38280140 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.61 0.33 5.13e-8 Bladder cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18346038 chr20:33264828 PIGU -0.46 -6.47 -0.37 4.63e-10 Gut microbiota (bacterial taxa); CESC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg05564831 chr3:52568323 NT5DC2 0.44 6.69 0.38 1.3100000000000001e-10 Bipolar disorder; CESC cis rs9303401 0.659 rs35564417 chr17:56718286 G/T cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.13 0.63 1.12e-30 Cognitive test performance; CESC cis rs12822507 0.899 rs4763859 chr12:12787005 G/A cg09462578 chr12:12878428 APOLD1 -0.44 -5.51 -0.32 8.36e-8 Systemic lupus erythematosus; CESC cis rs4843747 0.671 rs8053377 chr16:88106465 A/G cg06374794 chr16:88002281 BANP 0.41 5.29 0.31 2.62e-7 Menopause (age at onset); CESC cis rs9287719 0.967 rs7355649 chr2:10748094 C/A cg02196655 chr2:10830764 NOL10 -0.34 -5.16 -0.3 4.73e-7 Prostate cancer; CESC cis rs3780486 0.846 rs3824458 chr9:33144809 C/T cg13443165 chr9:33130375 B4GALT1 0.46 6.63 0.38 1.89e-10 IgG glycosylation; CESC cis rs35955747 0.902 rs140074 chr22:31725634 C/G cg02404636 chr22:31891804 SFI1 0.36 5.16 0.3 4.88e-7 Neutrophil count;Sum basophil neutrophil counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14942134 chr8:94929220 PDP1 0.56 6.66 0.38 1.61e-10 Gut microbiome composition (summer); CESC cis rs8051149 0.688 rs55776570 chr16:87869516 C/G cg01829163 chr16:87871160 SLC7A5 -0.57 -7.1 -0.4 1.17e-11 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19154858 chr13:48807339 ITM2B 0.56 6.67 0.38 1.48e-10 Gut microbiome composition (summer); CESC cis rs6543140 0.964 rs6543138 chr2:103066132 G/A cg04239558 chr2:103089729 SLC9A4 0.45 5.66 0.33 3.94e-8 Blood protein levels; CESC cis rs782590 0.774 rs782637 chr2:55894247 T/C cg18811423 chr2:55921094 PNPT1 0.78 12.91 0.62 6.55e-30 Metabolic syndrome; CESC cis rs1801251 0.896 rs2305141 chr2:233684402 A/G cg08000102 chr2:233561755 GIGYF2 -0.72 -11.24 -0.57 3.17e-24 Coronary artery disease; CESC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg10691866 chr7:65817282 TPST1 0.31 5.33 0.31 2.06e-7 Aortic root size; CESC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg16606324 chr3:10149918 C3orf24 0.43 5.22 0.31 3.71e-7 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07645736 chr6:137243249 SLC35D3 -0.58 -6.71 -0.38 1.16e-10 Gut microbiome composition (summer); CESC cis rs8078723 0.677 rs11658328 chr17:38149236 T/C cg17467752 chr17:38218738 THRA -0.56 -8.52 -0.46 1.22e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15163040 chr3:167813423 GOLIM4 0.48 6.53 0.37 3.39e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs5758343 1 rs5758343 chr22:41816652 A/T cg03806693 chr22:41940476 POLR3H 1.2 14.5 0.67 1.86e-35 Allergic disease (asthma, hay fever or eczema); CESC cis rs4450798 0.793 rs28454765 chr3:13758013 A/G cg23332027 chr3:13681764 NA 0.38 5.18 0.3 4.33e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7617480 0.648 rs4858830 chr3:48734002 T/C cg07636037 chr3:49044803 WDR6 0.76 9.61 0.51 6.12e-19 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs2131877 0.913 rs1874101 chr3:194849057 C/T cg24618514 chr3:194868507 C3orf21 -0.43 -5.21 -0.3 3.84e-7 Non-small cell lung cancer; CESC trans rs11098499 0.738 rs34965784 chr4:120361586 G/C cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs7998202 0.775 rs282580 chr13:113357540 T/C cg02820901 chr13:113351484 ATP11A 0.66 5.56 0.32 6.47e-8 Glycated hemoglobin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21062897 chr14:50999680 MAP4K5;ATL1 0.63 7.72 0.43 2.38e-13 Gut microbiome composition (summer); CESC cis rs911555 0.755 rs1116095 chr14:103931879 A/G cg24130564 chr14:104152367 KLC1 0.48 6.26 0.36 1.53e-9 Intelligence (multi-trait analysis); CESC trans rs3780486 0.718 rs3818593 chr9:33120706 A/G cg20290983 chr6:43655470 MRPS18A 0.7 8.08 0.44 2.36e-14 IgG glycosylation; CESC cis rs561341 0.714 rs55925849 chr17:30253085 C/T cg00745463 chr17:30367425 LRRC37B -0.85 -7.62 -0.42 4.38e-13 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06610368 chr5:86564371 RASA1 0.55 6.36 0.36 9.05e-10 Gut microbiome composition (summer); CESC cis rs7953508 0.506 rs930316 chr12:93967035 A/G cg18151635 chr12:93972918 NA -0.44 -5.87 -0.34 1.31e-8 Pubertal anthropometrics; CESC cis rs4704187 0.595 rs7717337 chr5:74377001 T/C cg03227963 chr5:74354835 NA 0.32 5.95 0.34 8.68e-9 Response to amphetamines; CESC cis rs4835473 0.750 rs57610804 chr4:144895494 T/C cg25736465 chr4:144833511 NA 0.39 5.97 0.34 7.43e-9 Immature fraction of reticulocytes; CESC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg23048001 chr7:2026167 MAD1L1 0.47 6.08 0.35 4.08e-9 Bipolar disorder and schizophrenia; CESC cis rs11098499 0.955 rs35916640 chr4:120155852 T/C cg09307838 chr4:120376055 NA 0.87 11.39 0.57 1.02e-24 Corneal astigmatism; CESC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg06481639 chr22:41940642 POLR3H -0.63 -6.66 -0.38 1.55e-10 Vitiligo; CESC cis rs12971120 0.891 rs12968731 chr18:72169708 G/T cg25817165 chr18:72167213 CNDP2 -0.59 -7.2 -0.4 6.21e-12 Refractive error; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06684987 chr19:45567721 SFRS16 0.53 6.93 0.39 3.13e-11 Fibrinogen levels; CESC cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg04398451 chr17:18023971 MYO15A 0.78 11.61 0.58 1.85e-25 Total body bone mineral density; CESC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg12963246 chr6:28129442 ZNF389 -0.49 -6.35 -0.36 9.49e-10 Parkinson's disease; CESC cis rs1348850 0.914 rs9789582 chr2:178330173 C/G cg23306229 chr2:178417860 TTC30B 0.65 7.98 0.44 4.33e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4975709 1.000 rs4975709 chr5:1877280 A/C cg12288994 chr5:1860383 NA 0.35 5.84 0.34 1.52e-8 Cardiovascular disease risk factors; CESC cis rs3796352 1.000 rs6445557 chr3:53083969 C/T cg12962167 chr3:53033115 SFMBT1 -0.57 -5.78 -0.33 2.11e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs12681288 0.748 rs2701935 chr8:1028618 T/A cg15309053 chr8:964076 NA 0.38 6.03 0.35 5.42e-9 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21269758 chr1:25870003 LDLRAP1 0.54 6.32 0.36 1.13e-9 Gut microbiome composition (summer); CESC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg06074448 chr4:187884817 NA -0.37 -5.43 -0.32 1.27e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs67311347 0.911 rs9863737 chr3:40439836 C/T cg09455208 chr3:40491958 NA 0.5 8.28 0.45 6.1e-15 Renal cell carcinoma; CESC cis rs1062177 1.000 rs2964571 chr5:151171256 C/T cg12924095 chr5:151150029 G3BP1 0.49 6.44 0.37 5.67e-10 Preschool internalizing problems; CESC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg08888203 chr3:10149979 C3orf24 0.47 5.28 0.31 2.69e-7 Alzheimer's disease; CESC cis rs506597 0.920 rs221797 chr7:100285974 A/C cg10426581 chr7:100472382 SRRT -0.69 -5.39 -0.31 1.57e-7 Pursuit maintenance gain in psychotic disorders; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26384201 chr3:50336345 HYAL3;NAT6 -0.49 -7.13 -0.4 9.37e-12 Gut microbiota (bacterial taxa); CESC cis rs644799 0.965 rs11021310 chr11:95502106 A/C cg25478527 chr11:95522999 CEP57;FAM76B 0.56 6.99 0.39 2.19e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs950169 0.845 rs4106951 chr15:84833394 C/G cg17507749 chr15:85114479 UBE2QP1 0.55 6.25 0.36 1.66e-9 Schizophrenia; CESC cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg18305652 chr10:134549665 INPP5A 0.46 6.58 0.37 2.48e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6060717 0.610 rs1891154 chr20:34617129 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -7.83 -0.43 1.17e-13 Hip circumference adjusted for BMI; CESC cis rs34172651 0.917 rs1465422 chr16:24772486 C/T cg06028605 chr16:24865363 SLC5A11 0.35 5.43 0.32 1.29e-7 Intelligence (multi-trait analysis); CESC cis rs4076764 0.958 rs11590567 chr1:163396438 A/G cg24596788 chr1:163392923 NA -0.51 -7.44 -0.42 1.37e-12 Motion sickness; CESC cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg23711669 chr6:146136114 FBXO30 -0.94 -12.27 -0.6 1.06e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs1182196 0.502 rs757786 chr7:2836019 C/T cg09658497 chr7:2847517 GNA12 -0.43 -6.86 -0.39 4.79e-11 Plateletcrit; CESC cis rs2228479 0.850 rs17233455 chr16:89816407 A/G cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1881797 1.000 rs12081895 chr1:247686666 C/G cg21399703 chr1:247681439 NA 0.55 7.37 0.41 2.13e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs116095464 0.558 rs34629844 chr5:200829 A/G cg16372103 chr5:203701 NA 0.51 5.66 0.33 4.01e-8 Breast cancer; CESC trans rs1728785 1.000 rs12918865 chr16:68566546 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs17001868 0.568 rs9611312 chr22:40734790 T/C cg07138101 chr22:40742427 ADSL 0.54 5.18 0.3 4.49e-7 Mammographic density (dense area); CESC cis rs2204008 0.837 rs11519926 chr12:38348992 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.65 0.55 2.87e-22 Bladder cancer; CESC trans rs11098499 0.722 rs10025925 chr4:120271744 A/T cg25214090 chr10:38739885 LOC399744 0.6 8.3 0.45 5.33e-15 Corneal astigmatism; CESC cis rs7843479 0.930 rs4871903 chr8:21827833 C/T cg17168535 chr8:21777572 XPO7 -0.47 -6.36 -0.36 9.05e-10 Mean corpuscular volume; CESC cis rs12973672 0.812 rs12984022 chr19:35754011 A/C cg12095397 chr19:35769544 USF2 0.5 5.96 0.34 7.98e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs938554 0.657 rs7660895 chr4:9985445 A/G cg00071950 chr4:10020882 SLC2A9 0.45 5.79 0.33 2.03e-8 Blood metabolite levels; CESC cis rs4746818 1.000 rs4746818 chr10:70884687 G/T cg11621586 chr10:70884670 VPS26A 0.99 13.28 0.63 3.38e-31 Left atrial antero-posterior diameter; CESC trans rs8026198 0.568 rs56670003 chr15:42548434 G/A cg24724587 chr1:86044103 DDAH1 -0.58 -6.0 -0.35 6.4e-9 Fibrinogen levels; CESC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.53 8.02 0.44 3.41e-14 Bipolar disorder; CESC cis rs644799 0.965 rs499076 chr11:95546341 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs17685 0.743 rs10277259 chr7:75802674 A/C cg19862616 chr7:65841803 NCRNA00174 0.84 12.03 0.59 6.77e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg20503657 chr10:835505 NA 0.7 6.32 0.36 1.07e-9 Eosinophil percentage of granulocytes; CESC cis rs7542091 0.704 rs7550330 chr1:210044587 G/A cg21951975 chr1:209979733 IRF6 0.47 8.25 0.45 7.51e-15 Monobrow; CESC cis rs2072499 1.000 rs2241107 chr1:156182710 C/T cg24450063 chr1:156163899 SLC25A44 -0.96 -18.22 -0.75 1.21e-48 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17875760 chr17:1802361 RPA1 -0.56 -6.72 -0.38 1.1e-10 Gut microbiome composition (summer); CESC cis rs9911578 0.935 rs420878 chr17:56709077 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.46 0.32 1.12e-7 Intelligence (multi-trait analysis); CESC cis rs2239547 0.522 rs2710345 chr3:52976075 T/C cg11645453 chr3:52864694 ITIH4 -0.31 -5.13 -0.3 5.54e-7 Schizophrenia; CESC cis rs748404 0.697 rs504417 chr15:43554226 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.98 0.44 4.38e-14 Lung cancer; CESC trans rs2727020 0.523 rs7948958 chr11:49506749 G/A cg15704280 chr7:45808275 SEPT13 0.83 10.19 0.53 8.77e-21 Coronary artery disease; CESC cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg05283184 chr6:79620031 NA -0.44 -6.64 -0.38 1.74e-10 Intelligence (multi-trait analysis); CESC cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg24308560 chr3:49941425 MST1R -0.59 -8.26 -0.45 6.88e-15 Body mass index; CESC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg22143856 chr6:28129313 ZNF389 0.52 6.77 0.38 8.31e-11 Depression; CESC cis rs7587476 0.822 rs13018304 chr2:215682218 T/G cg04004882 chr2:215674386 BARD1 0.53 5.94 0.34 8.87e-9 Neuroblastoma; CESC cis rs3768617 0.782 rs10752893 chr1:183046261 C/T ch.1.3577855R chr1:183094577 LAMC1 0.66 9.15 0.49 1.56e-17 Fuchs's corneal dystrophy; CESC cis rs1847202 0.592 rs13073005 chr3:72951007 C/T cg25664220 chr3:72788482 NA -0.38 -5.57 -0.32 6.3e-8 Motion sickness; CESC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg18876405 chr7:65276391 NA 0.48 5.52 0.32 8.28e-8 Aortic root size; CESC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg22433210 chr17:43662623 NA 0.96 10.7 0.55 1.87e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12075144 chr3:155588060 GMPS 0.54 6.16 0.35 2.68e-9 Gut microbiome composition (summer); CESC cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -8.19 -0.45 1.1e-14 Monocyte percentage of white cells; CESC trans rs17685 0.712 rs1639620 chr7:75704090 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 12.47 0.61 2.13e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs66887589 0.616 rs11098497 chr4:120187068 C/T cg09307838 chr4:120376055 NA 0.68 9.52 0.5 1.13e-18 Diastolic blood pressure; CESC cis rs3126085 0.560 rs3120666 chr1:152316981 G/C cg03465714 chr1:152285911 FLG 0.42 5.04 0.3 8.66e-7 Atopic dermatitis; CESC cis rs11112613 0.713 rs17041546 chr12:105950801 G/T cg03607813 chr12:105948248 NA -0.57 -7.28 -0.41 3.7e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs116095464 0.558 rs2288459 chr5:231143 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.22 0.31 3.68e-7 Breast cancer; CESC cis rs6570726 0.764 rs4896821 chr6:145896181 G/A cg05347473 chr6:146136440 FBXO30 0.48 6.44 0.37 5.62e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg24399712 chr22:39784796 NA -0.72 -10.38 -0.54 2.07e-21 Intelligence (multi-trait analysis); CESC cis rs796364 0.806 rs35200468 chr2:201110368 G/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.7 -6.31 -0.36 1.14e-9 Schizophrenia; CESC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg06456125 chr7:65229604 NA 0.39 5.05 0.3 8.06e-7 Aortic root size; CESC cis rs2806561 0.929 rs2867315 chr1:23541286 C/T cg12483005 chr1:23474871 LUZP1 -0.33 -5.33 -0.31 2.07e-7 Height; CESC cis rs7959452 0.640 rs11177599 chr12:69721970 G/A cg14784868 chr12:69753453 YEATS4 0.73 10.44 0.54 1.35e-21 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26903090 chr16:3019041 PAQR4 0.56 6.65 0.38 1.65e-10 Gut microbiome composition (summer); CESC cis rs9400271 0.632 rs9384703 chr6:109586803 A/G cg01475377 chr6:109611718 NA -0.47 -7.32 -0.41 2.95e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs2717559 0.542 rs11777634 chr8:143887957 C/T cg17252645 chr8:143867129 LY6D -0.31 -5.33 -0.31 2.07e-7 Urinary tract infection frequency; CESC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg08968635 chr6:28129556 ZNF389 0.39 5.17 0.3 4.51e-7 Depression; CESC cis rs962856 1.000 rs979043 chr2:67566281 T/C cg09028215 chr2:67624308 ETAA1 -0.4 -5.11 -0.3 6.05e-7 Pancreatic cancer; CESC cis rs2652822 0.525 rs2053633 chr15:63505649 G/A cg02713581 chr15:63449717 RPS27L 0.49 6.35 0.36 9.23e-10 Metabolic traits; CESC cis rs1707322 0.721 rs10890336 chr1:46111056 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.4 0.41 1.77e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9300255 0.596 rs10732573 chr12:123743883 G/C cg00376283 chr12:123451042 ABCB9 0.65 8.86 0.48 1.18e-16 Neutrophil percentage of white cells; CESC cis rs68170813 0.559 rs17428071 chr7:106878200 C/G cg02696742 chr7:106810147 HBP1 -0.52 -5.08 -0.3 7.2e-7 Coronary artery disease; CESC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs17376456 0.877 rs10055340 chr5:93317644 T/C cg21475434 chr5:93447410 FAM172A 0.75 6.78 0.38 7.96e-11 Diabetic retinopathy; CESC cis rs7584330 0.518 rs77789507 chr2:238440972 C/T cg14458575 chr2:238380390 NA 0.69 6.44 0.37 5.43e-10 Prostate cancer; CESC cis rs12973672 0.812 rs10419959 chr19:35764705 G/A cg12095397 chr19:35769544 USF2 0.51 6.18 0.35 2.4e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg14820908 chr5:178986412 RUFY1 0.42 6.11 0.35 3.55e-9 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23788167 chr9:74979561 ZFAND5 -0.57 -6.63 -0.38 1.92e-10 Gut microbiome composition (summer); CESC cis rs722599 0.748 rs11623342 chr14:75347937 A/C cg11812906 chr14:75593930 NEK9 -0.45 -5.43 -0.32 1.25e-7 IgG glycosylation; CESC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg17366294 chr4:99064904 C4orf37 0.57 7.87 0.44 8.87e-14 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 1.000 rs72781663 chr2:24221694 C/G cg08917208 chr2:24149416 ATAD2B 0.95 8.35 0.46 3.75e-15 Lymphocyte counts; CESC cis rs2120019 1.000 rs60425110 chr15:75333000 T/A cg17294928 chr15:75287854 SCAMP5 -0.74 -8.33 -0.46 4.42e-15 Blood trace element (Zn levels); CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg07507251 chr3:52567010 NT5DC2 0.47 9.28 0.5 6.45e-18 Electroencephalogram traits; CESC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg22535103 chr8:58192502 C8orf71 -0.81 -8.94 -0.48 6.75e-17 Developmental language disorder (linguistic errors); CESC cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg16339924 chr4:17578868 LAP3 0.73 9.17 0.49 1.32e-17 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg25036284 chr2:26402008 FAM59B 0.76 7.75 0.43 1.97e-13 Gut microbiome composition (summer); CESC cis rs1443512 0.796 rs1822437 chr12:54340077 A/G cg17410650 chr12:54324560 NA 0.49 8.31 0.45 5.03e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs2066819 1.000 rs59295315 chr12:56708576 G/A cg26734620 chr12:56694298 CS 1.03 6.25 0.36 1.65e-9 Psoriasis vulgaris; CESC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg22508957 chr16:3507546 NAT15 0.59 9.56 0.51 8.29e-19 Tuberculosis; CESC cis rs4906332 1.000 rs35344594 chr14:103955792 A/G cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.49e-10 Coronary artery disease; CESC cis rs4730250 0.707 rs61014091 chr7:106810107 A/C cg02696742 chr7:106810147 HBP1 -0.59 -5.64 -0.33 4.37e-8 Osteoarthritis; CESC cis rs16917546 1.000 rs12768538 chr10:64406358 C/G cg03961010 chr10:64397487 ZNF365 0.37 6.05 0.35 5.01e-9 Basal cell carcinoma; CESC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.43 5.44 0.32 1.2e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23318560 chr14:64854531 MTHFD1 -0.61 -7.11 -0.4 1.08e-11 Gut microbiome composition (summer); CESC cis rs11122272 0.735 rs971534 chr1:231521971 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs3008870 1.000 rs2755248 chr1:67492624 A/G cg02640540 chr1:67518911 SLC35D1 0.5 5.36 0.31 1.84e-7 Lymphocyte percentage of white cells; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg18688230 chr12:89747628 DUSP6 -0.46 -6.01 -0.35 6.01e-9 Recombination measurement; CESC cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg26597838 chr10:835615 NA 1.18 11.34 0.57 1.52e-24 Eosinophil percentage of granulocytes; CESC trans rs459571 0.959 rs455381 chr9:136905577 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.6 -7.69 -0.43 2.96e-13 Platelet distribution width; CESC cis rs9611565 0.559 rs13056262 chr22:42081921 A/G cg06481639 chr22:41940642 POLR3H 0.57 5.74 0.33 2.58e-8 Vitiligo; CESC cis rs73206853 0.609 rs61582364 chr12:110967847 T/G cg12870014 chr12:110450643 ANKRD13A 0.65 5.65 0.33 4.09e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.0 10.08 0.53 1.96e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9611565 0.592 rs5751139 chr22:42099981 G/C cg06634786 chr22:41940651 POLR3H 0.66 6.64 0.38 1.73e-10 Vitiligo; CESC cis rs2820292 0.619 rs12119907 chr1:201828755 T/C cg06775570 chr1:201857621 SHISA4 -0.32 -5.1 -0.3 6.41e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs28374715 0.578 rs13313520 chr15:41629127 T/G cg02330683 chr15:41787940 ITPKA 0.48 5.69 0.33 3.35e-8 Ulcerative colitis; CESC cis rs10779751 0.734 rs2791647 chr1:11132801 G/A cg08854313 chr1:11322531 MTOR 0.76 10.24 0.53 5.91e-21 Body mass index; CESC cis rs8028182 0.636 rs4075522 chr15:75864335 G/A cg20655648 chr15:75932815 IMP3 0.49 6.06 0.35 4.75e-9 Sudden cardiac arrest; CESC cis rs4268898 0.717 rs3731626 chr2:24427864 G/A cg06627628 chr2:24431161 ITSN2 -0.89 -10.17 -0.53 9.85e-21 Asthma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01484320 chr1:109757057 SARS -0.43 -6.1 -0.35 3.77e-9 Gambling; CESC cis rs735396 0.770 rs1169301 chr12:121431300 C/T cg25281562 chr12:121454272 C12orf43 0.53 6.68 0.38 1.43e-10 N-glycan levels; CESC cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg04450456 chr4:17643702 FAM184B 0.36 5.03 0.3 9.14e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9911578 1.000 rs9892062 chr17:56976981 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.41 5.41 0.32 1.38e-7 Intelligence (multi-trait analysis); CESC cis rs1707322 0.963 rs12076580 chr1:46258159 G/A cg03146154 chr1:46216737 IPP 0.8 11.02 0.56 1.72e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2073016 0.925 rs2073014 chr6:41029109 C/T cg14418226 chr6:40996092 UNC5CL -0.48 -5.58 -0.32 6.07e-8 Progression free survival in metastatic colorectal cancer (CAPOX-B vs CAPOX-B plus cetuximab); CESC cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg18527119 chr7:66119851 NA -0.48 -5.22 -0.31 3.54e-7 Aortic root size; CESC cis rs78366141 0.649 rs78179026 chr4:89657456 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.88 5.86 0.34 1.34e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs9611519 0.754 rs4820435 chr22:41652846 G/T cg03806693 chr22:41940476 POLR3H -0.74 -8.18 -0.45 1.17e-14 Neuroticism; CESC cis rs35306767 0.953 rs12762973 chr10:960761 C/G cg20503657 chr10:835505 NA 0.76 8.0 0.44 3.79e-14 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10462529 chr17:78880748 RPTOR -0.57 -6.9 -0.39 3.73e-11 Gut microbiome composition (summer); CESC cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg20891283 chr12:69753455 YEATS4 0.6 8.32 0.45 4.8e-15 Blood protein levels; CESC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.78 0.38 7.61e-11 Platelet count; CESC cis rs6582630 0.519 rs9738104 chr12:38338459 A/C cg13010199 chr12:38710504 ALG10B 0.53 6.56 0.37 2.83e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.36 0.31 1.82e-7 Tonsillectomy; CESC cis rs3857067 0.967 rs1904096 chr4:95012684 C/A cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.53 -0.42 8.12e-13 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06288634 chr16:53164514 CHD9 0.54 6.24 0.36 1.73e-9 Gut microbiome composition (summer); CESC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg06600287 chr1:53387719 ECHDC2 -0.29 -5.08 -0.3 7e-7 Monocyte count; CESC cis rs10791323 0.559 rs10750548 chr11:133729469 A/G cg15485101 chr11:133734466 NA 0.36 5.84 0.34 1.56e-8 Childhood ear infection; CESC cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg14345882 chr6:26364793 BTN3A2 -0.41 -5.15 -0.3 5.2e-7 Intelligence (multi-trait analysis); CESC cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg12386194 chr3:101231763 SENP7 0.57 6.56 0.37 2.81e-10 Colonoscopy-negative controls vs population controls; CESC cis rs2242116 0.592 rs6442039 chr3:46960797 C/G cg02527881 chr3:46936655 PTH1R -0.43 -5.3 -0.31 2.44e-7 Birth weight; CESC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.15 0.4 8.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg05340658 chr4:99064831 C4orf37 0.77 11.71 0.58 8.52e-26 Colonoscopy-negative controls vs population controls; CESC cis rs2963155 1.000 rs2963155 chr5:142756004 C/T cg17617527 chr5:142782415 NR3C1 -0.49 -5.2 -0.3 3.99e-7 Breast cancer; CESC cis rs9486719 0.947 rs12213375 chr6:96902134 A/G cg18709589 chr6:96969512 KIAA0776 -0.56 -6.15 -0.35 2.88e-9 Migraine;Coronary artery disease; CESC cis rs12893597 0.821 rs12896434 chr14:76816746 C/T cg20290672 chr14:76816747 NA -0.41 -5.87 -0.34 1.31e-8 Maximal oxygen uptake response; CESC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg11890956 chr21:40555474 PSMG1 -0.94 -15.36 -0.69 1.62e-38 Cognitive function; CESC cis rs910316 0.763 rs735452 chr14:75497984 A/G cg08847533 chr14:75593920 NEK9 -0.95 -17.12 -0.72 9.25e-45 Height; CESC cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg10523679 chr1:76189770 ACADM 0.69 7.83 0.43 1.15e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs820218 0.743 rs3744000 chr17:73704333 C/T cg01592526 chr17:73663357 RECQL5;SAP30BP -0.39 -5.26 -0.31 2.93e-7 Rotator cuff tears; CESC cis rs9911578 0.967 rs9907940 chr17:56663842 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.14 0.68 9.87e-38 Intelligence (multi-trait analysis); CESC cis rs60843830 0.662 rs6721594 chr2:305203 C/T cg00108164 chr2:264199 ACP1;SH3YL1 -0.68 -8.94 -0.48 6.62e-17 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1153858 1.000 rs12594857 chr15:45667178 A/G cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.94 0.59 1.43e-26 Alzheimer's disease; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg21518056 chr19:33183187 NUDT19 0.48 6.2 0.36 2.21e-9 Breast cancer;Type 2 diabetes; CESC cis rs1670533 1.000 rs935970 chr4:1045323 C/G cg04106633 chr4:1044584 NA -0.42 -5.26 -0.31 3.04e-7 Recombination rate (females); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19319490 chr7:65447113 GUSB 0.57 7.29 0.41 3.62e-12 Gut microbiome composition (summer); CESC cis rs7829975 0.714 rs59046059 chr8:8670736 C/A cg15556689 chr8:8085844 FLJ10661 0.44 5.62 0.33 4.87e-8 Mood instability; CESC cis rs910316 0.967 rs175505 chr14:75529619 C/T cg15467112 chr14:75489610 MLH3 -0.34 -5.16 -0.3 4.9e-7 Height; CESC cis rs6540556 0.635 rs17389184 chr1:209916789 C/T cg05527609 chr1:210001259 C1orf107 -0.74 -7.53 -0.42 8.01e-13 Red blood cell count; CESC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg07414643 chr4:187882934 NA 0.52 7.22 0.41 5.6e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg13664146 chr17:71228606 C17orf80;FAM104A 0.44 6.03 0.35 5.39e-9 Tetralogy of Fallot; CESC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg08859206 chr1:53392774 SCP2 -0.58 -7.94 -0.44 5.85e-14 Monocyte count; CESC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg04414720 chr1:150670196 GOLPH3L 0.56 7.38 0.41 1.99e-12 Melanoma; CESC cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.39 -6.8 -0.39 6.98e-11 Hemoglobin concentration; CESC cis rs3820928 0.709 rs10178202 chr2:227914561 C/T cg05526886 chr2:227700861 RHBDD1 -0.46 -5.35 -0.31 1.93e-7 Pulmonary function; CESC cis rs1006703 0.544 rs10153291 chr17:3833740 G/A cg06463185 chr17:3833770 ATP2A3 -0.66 -6.35 -0.36 9.3e-10 Glucose homeostasis traits; CESC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg24531977 chr5:56204891 C5orf35 -0.83 -11.11 -0.56 8.79e-24 Initial pursuit acceleration; CESC cis rs8114671 0.904 rs6060197 chr20:33654315 C/T cg24642439 chr20:33292090 TP53INP2 -0.47 -5.7 -0.33 3.19e-8 Height; CESC cis rs73206853 0.686 rs11829358 chr12:111126636 A/G cg12870014 chr12:110450643 ANKRD13A 0.67 5.11 0.3 6.05e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2228479 0.717 rs11649210 chr16:89807233 C/G cg04287289 chr16:89883240 FANCA 0.65 5.93 0.34 9.41e-9 Skin colour saturation; CESC cis rs116095464 0.558 rs10055405 chr5:265666 C/T cg10591111 chr5:226296 SDHA -0.52 -6.24 -0.36 1.7e-9 Breast cancer; CESC cis rs3740713 1.000 rs16935432 chr11:18470487 G/A cg23797887 chr11:18477753 LDHAL6A -0.54 -5.21 -0.31 3.72e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg15320075 chr8:145703422 NA 0.64 8.66 0.47 4.66e-16 Age at first birth; CESC cis rs4730250 0.707 rs6946931 chr7:106788621 G/T cg02696742 chr7:106810147 HBP1 -0.55 -5.16 -0.3 4.91e-7 Osteoarthritis; CESC cis rs2777491 1.000 rs2730057 chr15:41736275 C/A cg20272979 chr15:41787780 ITPKA 0.44 6.4 0.37 7.03e-10 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09039206 chr10:60028728 CISD1;IPMK 0.54 6.19 0.36 2.32e-9 Gut microbiome composition (summer); CESC cis rs8018808 0.935 rs11623826 chr14:77912862 A/C cg20045696 chr14:77926864 AHSA1 0.42 5.83 0.34 1.61e-8 Myeloid white cell count; CESC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.87 0.65 2.88e-33 Prudent dietary pattern; CESC trans rs3780486 0.846 rs10738905 chr9:33123627 A/G cg04842962 chr6:43655489 MRPS18A 0.99 19.07 0.76 1.21e-51 IgG glycosylation; CESC cis rs13095912 1.000 rs6762208 chr3:185331165 A/C cg11274856 chr3:185301563 NA -0.37 -5.96 -0.34 8.1e-9 Systolic blood pressure; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg19872317 chr14:65346686 NA -0.47 -6.27 -0.36 1.44e-9 Height; CESC cis rs72945132 0.882 rs17160777 chr11:70163723 T/C cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.27 0.76 2.4e-52 Height; CESC trans rs9929218 0.953 rs9939049 chr16:68812301 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.6 -7.78 -0.43 1.6e-13 Colorectal cancer; CESC cis rs6582630 0.519 rs1607868 chr12:38385512 G/T cg13010199 chr12:38710504 ALG10B 0.47 6.05 0.35 4.84e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs3008870 1.000 rs17497828 chr1:67452322 G/A cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -13.17 -0.63 7.98e-31 Lymphocyte percentage of white cells; CESC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg05368731 chr17:41323189 NBR1 0.54 7.54 0.42 7.29e-13 Menopause (age at onset); CESC cis rs258892 0.895 rs34660 chr5:72151858 T/A cg21869765 chr5:72125136 TNPO1 0.44 5.55 0.32 6.92e-8 Small cell lung carcinoma; CESC cis rs1348850 0.567 rs4893838 chr2:178531436 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 6.95 0.39 2.92e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs55788414 1.000 rs7499792 chr16:81184318 C/T cg06400318 chr16:81190750 PKD1L2 -0.6 -6.77 -0.38 8.45e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs9905704 0.914 rs34556895 chr17:56826953 G/T cg12560992 chr17:57184187 TRIM37 0.61 7.09 0.4 1.25e-11 Testicular germ cell tumor; CESC cis rs6429082 0.755 rs291367 chr1:235690800 G/A cg26050004 chr1:235667680 B3GALNT2 0.65 8.68 0.47 3.96e-16 Adiposity; CESC trans rs61931739 0.817 rs11053071 chr12:34201400 A/G cg26384229 chr12:38710491 ALG10B 0.46 6.3 0.36 1.2e-9 Morning vs. evening chronotype; CESC cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg12373951 chr3:133503437 NA 0.4 5.88 0.34 1.23e-8 Iron status biomarkers; CESC trans rs8056446 0.710 rs8059793 chr16:78189298 A/C cg19906694 chr5:60629770 ZSWIM6 0.49 6.26 0.36 1.53e-9 Pulmonary function (smoking interaction); CESC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg07507251 chr3:52567010 NT5DC2 0.32 5.53 0.32 7.76e-8 Bipolar disorder; CESC cis rs7937682 0.575 rs7127010 chr11:111770782 C/T cg09085632 chr11:111637200 PPP2R1B 0.91 11.81 0.59 3.87e-26 Primary sclerosing cholangitis; CESC cis rs6922893 1.000 rs7765509 chr6:71661689 A/T cg10766373 chr6:71666121 B3GAT2 -0.34 -5.59 -0.32 5.77e-8 Obesity-related traits; CESC cis rs6964587 0.626 rs7785941 chr7:91531024 T/C cg17063962 chr7:91808500 NA -0.45 -6.35 -0.36 9.5e-10 Breast cancer; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 5.51 0.32 8.61e-8 Electroencephalogram traits; CESC cis rs7267979 1.000 rs6115153 chr20:25325567 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.09 -0.74 3.41e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg26335602 chr6:28129616 ZNF389 0.46 5.92 0.34 9.99e-9 Depression; CESC cis rs796364 0.806 rs203767 chr2:200902411 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.88 -0.44 8.7e-14 Schizophrenia; CESC cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg25019033 chr10:957182 NA -0.58 -6.21 -0.36 2.03e-9 Eosinophil percentage of granulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09379601 chr19:12992224 DNASE2 0.52 6.89 0.39 4.08e-11 Gut microbiota (bacterial taxa); CESC cis rs5769765 0.955 rs5770750 chr22:50276828 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg00484396 chr16:3507460 NAT15 -0.56 -6.33 -0.36 1.04e-9 Tuberculosis; CESC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 8.88 0.48 1.02e-16 Platelet count; CESC cis rs1018836 0.923 rs6989123 chr8:91551234 A/T cg16814680 chr8:91681699 NA -0.71 -10.5 -0.54 8.8e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs60843830 0.661 rs11674325 chr2:105517 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.51 6.08 0.35 4.11e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs137699 0.652 rs2413589 chr22:39755689 C/T cg24399712 chr22:39784796 NA 0.48 5.45 0.32 1.15e-7 IgG glycosylation; CESC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg16325326 chr1:53192061 ZYG11B -0.53 -7.96 -0.44 5.13e-14 Monocyte count; CESC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg07308232 chr7:1071921 C7orf50 -0.46 -6.27 -0.36 1.43e-9 Longevity;Endometriosis; CESC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs9309473 1.000 rs7564890 chr2:73641853 T/C cg20560298 chr2:73613845 ALMS1 -0.54 -7.09 -0.4 1.21e-11 Metabolite levels; CESC cis rs3747547 0.892 rs17516779 chr9:37955265 A/G cg13774184 chr9:37916125 SHB 0.74 6.52 0.37 3.49e-10 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.11 0.3 6.08e-7 Menopause (age at onset); CESC cis rs9658691 0.607 rs9658757 chr10:90769455 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -5.3 -0.31 2.4e-7 Mosquito bite size; CESC trans rs61931739 0.500 rs6488221 chr12:34525671 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 8.03e-13 Morning vs. evening chronotype; CESC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg10691866 chr7:65817282 TPST1 0.31 5.23 0.31 3.43e-7 Aortic root size; CESC cis rs6570726 0.935 rs398060 chr6:145841515 C/T cg05347473 chr6:146136440 FBXO30 -0.5 -6.73 -0.38 1.07e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7671266 0.747 rs6827946 chr4:10151335 T/C cg00071950 chr4:10020882 SLC2A9 -0.52 -5.64 -0.33 4.4e-8 Cardiovascular disease risk factors; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04421424 chr19:57791681 ZNF460 0.55 7.2 0.4 6.28e-12 Gut microbiota (bacterial taxa); CESC cis rs7605827 0.930 rs3954894 chr2:15517656 T/C cg19274914 chr2:15703543 NA 0.35 6.11 0.35 3.61e-9 Educational attainment (years of education); CESC cis rs4787484 0.593 rs12917712 chr16:29882490 A/G cg01827781 chr16:29875145 LOC440356;CDIPT -0.4 -5.43 -0.32 1.3e-7 Response to taxane treatment (placlitaxel); CESC cis rs13256369 0.802 rs12153 chr8:8560909 G/C cg17143192 chr8:8559678 CLDN23 0.76 8.64 0.47 5.49e-16 Obesity-related traits; CESC cis rs9300255 0.602 rs1616131 chr12:123619838 G/A cg19016782 chr12:123741754 C12orf65 -0.38 -5.15 -0.3 5.08e-7 Neutrophil percentage of white cells; CESC cis rs713587 0.520 rs522806 chr2:25316584 C/A cg01884057 chr2:25150051 NA -0.3 -5.2 -0.3 4.01e-7 Body mass index in non-asthmatics; CESC cis rs18122 0.660 rs7572001 chr2:67521908 A/G cg09028215 chr2:67624308 ETAA1 -0.41 -5.11 -0.3 6.15e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4780401 0.755 rs7194034 chr16:11770777 A/G cg01061890 chr16:11836724 TXNDC11 -0.41 -5.36 -0.31 1.85e-7 Rheumatoid arthritis; CESC cis rs7635838 0.617 rs367745 chr3:11309274 T/C cg00170343 chr3:11313890 ATG7 0.6 8.61 0.47 6.56e-16 HDL cholesterol; CESC cis rs10504073 0.565 rs12056536 chr8:49890132 C/T cg00325661 chr8:49890786 NA -0.54 -8.14 -0.45 1.54e-14 Blood metabolite ratios; CESC cis rs6665290 0.935 rs11588904 chr1:227196211 T/C cg10327440 chr1:227177885 CDC42BPA -1.22 -32.88 -0.9 1.62e-95 Myeloid white cell count; CESC trans rs9929218 0.608 rs35158985 chr16:68796746 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.57 -0.47 8.77e-16 Colorectal cancer; CESC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.02 0.52 2.97e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3806843 0.735 rs813897 chr5:140070029 T/C cg26395211 chr5:140044315 WDR55 0.47 5.94 0.34 9.08e-9 Depressive symptoms (multi-trait analysis); CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg18538332 chr22:24372958 LOC391322 -0.69 -9.81 -0.52 1.39e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs8114671 0.662 rs6058146 chr20:33540529 A/G cg07148914 chr20:33460835 GGT7 0.42 5.38 0.31 1.62e-7 Height; CESC cis rs735396 0.965 rs2257962 chr12:121445808 T/C cg02403541 chr12:121454288 C12orf43 0.64 9.27 0.49 6.87e-18 N-glycan levels; CESC cis rs7247513 0.964 rs8105902 chr19:12718351 G/A cg01871581 chr19:12707946 ZNF490 -0.85 -13.38 -0.64 1.49e-31 Bipolar disorder; CESC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.93 0.39 3.29e-11 Bipolar disorder; CESC cis rs5758511 0.680 rs1033460 chr22:42619308 A/G cg00645731 chr22:42541494 CYP2D7P1 0.59 8.71 0.47 3.36e-16 Birth weight; CESC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.73 -0.38 1.03e-10 Electroencephalogram traits; CESC cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg02297831 chr4:17616191 MED28 0.51 6.18 0.35 2.44e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.11 19.31 0.76 1.86e-52 Height; CESC cis rs1847202 0.826 rs11925587 chr3:72952227 A/G cg25664220 chr3:72788482 NA 0.38 5.53 0.32 7.87e-8 Motion sickness; CESC cis rs12530845 0.673 rs4269479 chr7:135332379 C/T cg23117316 chr7:135346802 PL-5283 -0.55 -6.16 -0.35 2.7e-9 Red blood cell traits; CESC cis rs6460942 1.000 rs73053531 chr7:12317474 T/C cg06484146 chr7:12443880 VWDE -0.81 -8.78 -0.47 2.13e-16 Coronary artery disease; CESC cis rs713587 0.967 rs10182458 chr2:25150641 A/G cg01884057 chr2:25150051 NA 0.43 8.07 0.44 2.54e-14 Body mass index in non-asthmatics; CESC cis rs10392 0.543 rs1733 chr20:37581506 G/A cg27552599 chr20:37590471 DHX35 0.38 5.53 0.32 7.59e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg18876405 chr7:65276391 NA 0.61 8.12 0.45 1.78e-14 Aortic root size; CESC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.25e-11 Aortic root size; CESC cis rs11083475 0.607 rs6508816 chr19:39267783 G/A cg26703956 chr19:39260304 NA -0.29 -5.33 -0.31 2.08e-7 Heart rate; CESC cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg21573476 chr21:45109991 RRP1B -0.58 -8.4 -0.46 2.69e-15 Mean corpuscular volume; CESC trans rs208520 0.754 rs851592 chr6:66875175 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.67 -0.61 4.31e-29 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12952179 chr4:111866981 NA -0.6 -6.78 -0.38 7.95e-11 Gut microbiome composition (summer); CESC cis rs7116495 1.000 rs3750908 chr11:71822401 A/G cg10381502 chr11:71823885 C11orf51 0.69 5.61 0.33 5.03e-8 Severe influenza A (H1N1) infection; CESC cis rs5769765 0.773 rs7410291 chr22:50300078 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.49 -5.54 -0.32 7.17e-8 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05191435 chr6:7987870 MGC26597 -0.43 -6.15 -0.35 2.8e-9 Gut microbiota (bacterial taxa); CESC cis rs7267979 1.000 rs401166 chr20:25446308 C/G cg08601574 chr20:25228251 PYGB 0.37 5.31 0.31 2.31e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2456568 0.548 rs7113080 chr11:93657520 G/A cg26875233 chr11:93583750 C11orf90 -0.33 -5.87 -0.34 1.28e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs1551570 0.766 rs55752217 chr19:10218434 C/T cg16327482 chr19:10226339 EIF3G 0.42 6.9 0.39 3.77e-11 Narcolepsy; CESC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg18252515 chr7:66147081 NA 0.52 6.96 0.39 2.64e-11 Aortic root size; CESC cis rs9303401 0.615 rs7502342 chr17:56922629 C/A cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.69 0.61 3.78e-29 Cognitive test performance; CESC cis rs992157 0.798 rs2382818 chr2:219155907 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.66 -8.74 -0.47 2.72e-16 Colorectal cancer; CESC cis rs34375054 0.660 rs58624919 chr12:125596458 G/A cg25124228 chr12:125621409 AACS -0.56 -6.75 -0.38 9.19e-11 Post bronchodilator FEV1/FVC ratio; CESC cis rs2230307 0.536 rs6677998 chr1:100461046 G/A cg24955406 chr1:100503596 HIAT1 0.55 5.48 0.32 9.85e-8 Carotid intima media thickness; CESC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg24829409 chr8:58192753 C8orf71 -0.62 -6.32 -0.36 1.13e-9 Developmental language disorder (linguistic errors); CESC trans rs1814175 0.740 rs10839439 chr11:49918240 C/T cg03929089 chr4:120376271 NA -0.93 -15.69 -0.69 1.12e-39 Height; CESC cis rs863345 0.604 rs10908673 chr1:158503908 T/G cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs4595586 0.870 rs10876208 chr12:39287667 G/T cg26384229 chr12:38710491 ALG10B -0.38 -5.46 -0.32 1.07e-7 Morning vs. evening chronotype; CESC cis rs662064 0.962 rs648324 chr1:10556447 G/T cg20482658 chr1:10539492 PEX14 -0.38 -7.66 -0.43 3.5e-13 Asthma; CESC cis rs7819412 0.806 rs6980856 chr8:10938260 A/G cg21775007 chr8:11205619 TDH 0.43 6.19 0.36 2.3e-9 Triglycerides; CESC trans rs208520 0.837 rs208467 chr6:66914837 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.84 -9.91 -0.52 6.69e-20 Exhaled nitric oxide output; CESC cis rs9287719 0.870 rs728135 chr2:10745132 A/C cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg13628971 chr7:2884303 GNA12 0.64 8.77 0.47 2.21e-16 Height; CESC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg08392591 chr16:89556376 ANKRD11 0.63 8.57 0.47 8.75e-16 Multiple myeloma (IgH translocation); CESC cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg17628894 chr11:804452 LRDD 0.39 8.23 0.45 8.65e-15 Breast cancer; CESC cis rs447735 0.565 rs10852626 chr16:89914633 T/G cg27121462 chr16:89883253 FANCA 0.51 6.16 0.35 2.72e-9 Hemoglobin concentration; CESC cis rs7267979 0.844 rs869358 chr20:25374674 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -14.53 -0.67 1.38e-35 Liver enzyme levels (alkaline phosphatase); CESC trans rs4942242 0.640 rs9533563 chr13:44212127 A/G cg19169023 chr15:41853346 TYRO3 -0.62 -7.85 -0.43 1.03e-13 Response to tocilizumab in rheumatoid arthritis; CESC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg26343298 chr8:95960752 TP53INP1 0.36 5.98 0.34 7.06e-9 Type 2 diabetes; CESC cis rs7429990 0.965 rs34380889 chr3:47947182 C/T cg11946769 chr3:48343235 NME6 0.42 5.13 0.3 5.71e-7 Educational attainment (years of education); CESC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg08470875 chr2:26401718 FAM59B -0.73 -7.99 -0.44 4.05e-14 Gut microbiome composition (summer); CESC cis rs10979 1.000 rs12215667 chr6:143893213 T/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.21 -0.49 1.01e-17 Hypospadias; CESC cis rs6121246 0.559 rs6058465 chr20:30397691 G/A cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs2204008 0.630 rs12306932 chr12:38242029 C/T cg26384229 chr12:38710491 ALG10B -0.44 -5.68 -0.33 3.59e-8 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07355262 chr7:5347698 TNRC18 -0.53 -7.07 -0.4 1.36e-11 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg15017067 chr4:17643749 FAM184B 0.36 5.13 0.3 5.58e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17939001 chr1:197871836 C1orf53 -0.46 -6.04 -0.35 5.25e-9 Fibrinogen levels; CESC cis rs6460942 0.597 rs35589221 chr7:12535841 T/G cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs7503807 0.967 rs12949279 chr17:78558411 T/C cg09596252 chr17:78655493 RPTOR 0.46 6.36 0.36 8.67e-10 Obesity; CESC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC cis rs902774 0.554 rs4503623 chr12:53353759 T/C cg05393297 chr12:53359155 NA -0.6 -8.54 -0.46 1.08e-15 Prostate cancer; CESC cis rs6570726 0.870 rs370653 chr6:145823642 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg23283495 chr1:209979779 IRF6 0.51 7.55 0.42 7.09e-13 Cleft lip with or without cleft palate; CESC cis rs1728785 0.901 rs698715 chr16:68560896 A/G cg02972257 chr16:68554789 NA -0.62 -6.95 -0.39 2.88e-11 Ulcerative colitis; CESC cis rs7264396 0.513 rs3787169 chr20:34419884 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -9.46 -0.5 1.73e-18 Total cholesterol levels; CESC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg26354017 chr1:205819088 PM20D1 0.47 6.12 0.35 3.26e-9 Parkinson's disease; CESC cis rs35110281 0.720 rs162394 chr21:44943550 C/G cg01579765 chr21:45077557 HSF2BP 0.53 9.2 0.49 1.14e-17 Mean corpuscular volume; CESC cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg27347728 chr4:17578864 LAP3 0.45 5.32 0.31 2.21e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12765878 0.934 rs58543155 chr10:105643244 G/A cg11005552 chr10:105648138 OBFC1 0.35 5.1 0.3 6.34e-7 Coronary artery disease; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg18099408 chr3:52552593 STAB1 -0.44 -8.08 -0.44 2.29e-14 Electroencephalogram traits; CESC cis rs853679 0.882 rs4713140 chr6:28097193 C/T cg19592336 chr6:28129416 ZNF389 0.52 5.19 0.3 4.1e-7 Depression; CESC cis rs7258465 1.000 rs4808801 chr19:18571141 A/G cg11102782 chr19:18549136 ISYNA1 -0.36 -5.06 -0.3 7.78e-7 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01372608 chr1:116185223 VANGL1 0.48 6.09 0.35 3.85e-9 Gut microbiota (bacterial taxa); CESC cis rs79976124 0.842 rs1548154 chr6:66624910 G/A cg07460842 chr6:66804631 NA 0.72 8.45 0.46 1.91e-15 Type 2 diabetes; CESC cis rs3859192 0.561 rs12453343 chr17:38181176 C/A cg17344932 chr17:38183730 MED24;SNORD124 0.6 8.95 0.48 6.49e-17 White blood cell count; CESC cis rs75064307 0.834 rs7636575 chr3:108115862 C/T cg03329597 chr3:108125523 MYH15 -0.5 -5.72 -0.33 2.93e-8 Intelligence (multi-trait analysis); CESC cis rs10979 1.000 rs12211659 chr6:143898348 G/T cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs17376456 0.877 rs17083462 chr5:93462401 T/G cg21475434 chr5:93447410 FAM172A 0.82 7.55 0.42 6.97e-13 Diabetic retinopathy; CESC cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg20503657 chr10:835505 NA 0.78 7.64 0.42 4.09e-13 Eosinophil percentage of granulocytes; CESC cis rs6693567 0.565 rs12736375 chr1:150411912 T/C cg09579323 chr1:150459698 TARS2 0.49 6.12 0.35 3.3e-9 Migraine; CESC cis rs7727544 0.684 rs274567 chr5:131714409 C/T cg07395648 chr5:131743802 NA 0.45 5.95 0.34 8.3e-9 Blood metabolite levels; CESC cis rs7666738 0.830 rs34916200 chr4:98851593 C/T cg03467027 chr4:99064603 C4orf37 0.42 5.16 0.3 4.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10979 0.571 rs9386039 chr6:143916992 A/T cg25407410 chr6:143891975 LOC285740 0.45 5.64 0.33 4.43e-8 Hypospadias; CESC cis rs8014204 0.604 rs11625594 chr14:75389833 G/A cg08847533 chr14:75593920 NEK9 0.6 7.59 0.42 5.58e-13 Caffeine consumption; CESC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg00359181 chr2:38893519 GALM -0.63 -8.83 -0.48 1.47e-16 5-HTT brain serotonin transporter levels; CESC cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg11890956 chr21:40555474 PSMG1 1.2 22.09 0.81 4.83e-62 Cognitive function; CESC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg09323728 chr8:95962352 TP53INP1 0.34 6.42 0.37 6.29e-10 Type 2 diabetes; CESC cis rs2952156 0.959 rs1565922 chr17:37831035 A/G cg07936489 chr17:37558343 FBXL20 -0.54 -6.69 -0.38 1.3100000000000001e-10 Asthma; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15312298 chr8:127570908 FAM84B 0.47 6.65 0.38 1.67e-10 Systemic lupus erythematosus; CESC cis rs12142240 0.698 rs72677589 chr1:46817770 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12603476 chr10:82214649 TSPAN14 -0.46 -6.08 -0.35 4.28e-9 Fibrinogen levels; CESC cis rs9486719 0.947 rs9398072 chr6:96911304 T/C cg18709589 chr6:96969512 KIAA0776 0.48 5.72 0.33 2.9e-8 Migraine;Coronary artery disease; CESC cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg03388025 chr16:89894329 SPIRE2 0.36 6.58 0.37 2.47e-10 Vitiligo; CESC cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg13902645 chr11:5959945 NA -0.62 -7.4 -0.41 1.85e-12 DNA methylation (variation); CESC cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6500395 0.890 rs9936271 chr16:48601291 A/G cg04672837 chr16:48644449 N4BP1 0.52 6.43 0.37 6.06e-10 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20546810 chr20:2489835 ZNF343 0.58 6.11 0.35 3.61e-9 Gut microbiome composition (summer); CESC cis rs9811920 0.638 rs793471 chr3:99546335 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -5.86 -0.34 1.39e-8 Axial length; CESC cis rs2694528 0.686 rs6885703 chr5:59862790 T/C cg11474532 chr5:59995715 DEPDC1B 0.92 6.53 0.37 3.38e-10 Parkinson's disease; CESC cis rs4332037 0.576 rs62434668 chr7:1866901 G/A cg23422044 chr7:1970798 MAD1L1 -0.52 -5.2 -0.3 3.92e-7 Bipolar disorder; CESC cis rs1538970 1.000 rs7417107 chr1:45831915 G/C cg06784218 chr1:46089804 CCDC17 0.31 5.29 0.31 2.62e-7 Platelet count; CESC cis rs733592 0.507 rs56129148 chr12:48485530 T/C cg24011408 chr12:48396354 COL2A1 -0.5 -8.24 -0.45 7.94e-15 Plateletcrit; CESC cis rs8050907 0.744 rs11866840 chr16:4536354 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.89 5.66 0.33 3.84e-8 Obesity-related traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17675882 chr20:35374068 NDRG3 -0.48 -6.9 -0.39 3.88e-11 Gambling; CESC cis rs34311866 0.808 rs748483 chr4:952409 A/G cg07828340 chr4:882639 GAK 0.96 7.02 0.4 1.84e-11 Parkinson's disease; CESC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg11644478 chr21:40555479 PSMG1 1.05 16.84 0.72 9.02e-44 Cognitive function; CESC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg20243544 chr17:37824526 PNMT 0.5 6.37 0.36 8.22e-10 Glomerular filtration rate (creatinine); CESC cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 12.69 0.61 3.88e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26736321 chr22:42196593 CCDC134 0.57 6.14 0.35 3.07e-9 Gut microbiome composition (summer); CESC cis rs2354432 0.546 rs11240030 chr1:146882616 G/A cg25205988 chr1:146714368 CHD1L 0.88 9.35 0.5 3.8e-18 Mitochondrial DNA levels; CESC cis rs7178909 0.872 rs3931863 chr15:90433913 T/G cg19708238 chr15:90437601 AP3S2 0.42 5.84 0.34 1.5e-8 Common traits (Other); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg10392504 chr7:5464594 TNRC18 -0.49 -6.53 -0.37 3.35e-10 Height; CESC cis rs3087591 0.708 rs67065748 chr17:29605631 T/A cg24425628 chr17:29625626 OMG;NF1 0.42 5.25 0.31 3.14e-7 Hip circumference; CESC cis rs708547 0.830 rs1713994 chr4:57868367 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.75 9.87 0.52 9.04e-20 Response to bleomycin (chromatid breaks); CESC cis rs11098499 0.722 rs10006192 chr4:120263022 T/C cg09307838 chr4:120376055 NA 0.75 9.88 0.52 8.38e-20 Corneal astigmatism; CESC cis rs7267979 1.000 rs1888997 chr20:25298988 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -16.78 -0.72 1.5e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs2380220 0.808 rs2613553 chr6:95916704 A/G cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC trans rs1005277 0.577 rs4934906 chr10:38015028 C/T cg12057190 chr19:54976211 LENG9;CDC42EP5 0.42 6.04 0.35 5.32e-9 Extrinsic epigenetic age acceleration; CESC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg22920501 chr2:26401640 FAM59B 0.93 10.89 0.56 4.54e-23 Gut microbiome composition (summer); CESC cis rs9911578 1.000 rs8071916 chr17:56660279 A/G cg05425664 chr17:57184151 TRIM37 -0.47 -6.56 -0.37 2.87e-10 Intelligence (multi-trait analysis); CESC cis rs2070488 0.804 rs13085153 chr3:38461279 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.81 13.28 0.63 3.43e-31 Electrocardiographic conduction measures; CESC cis rs7618501 1.000 rs3749241 chr3:49744392 A/G cg24308560 chr3:49941425 MST1R 0.49 6.69 0.38 1.29e-10 Intelligence (multi-trait analysis); CESC cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg17509989 chr5:176798049 RGS14 -0.59 -6.96 -0.39 2.74e-11 Urinary electrolytes (magnesium/calcium ratio); CESC cis rs2072499 0.966 rs2853643 chr1:156184831 G/A cg25208724 chr1:156163844 SLC25A44 0.95 15.35 0.69 1.82e-38 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17297071 chr21:26934424 MIR155HG -0.58 -6.81 -0.39 6.45e-11 Gut microbiome composition (summer); CESC trans rs1908814 0.516 rs4840597 chr8:11796068 A/C cg15556689 chr8:8085844 FLJ10661 0.51 6.32 0.36 1.1e-9 Neuroticism; CESC cis rs6580649 0.941 rs4760677 chr12:48449163 C/T cg05342945 chr12:48394962 COL2A1 0.5 5.85 0.34 1.47e-8 Lung cancer; CESC trans rs11098499 0.826 rs4472123 chr4:120236630 T/A cg25214090 chr10:38739885 LOC399744 0.63 8.77 0.47 2.25e-16 Corneal astigmatism; CESC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.9 -0.56 4.33e-23 Alzheimer's disease; CESC cis rs6060987 1 rs6060987 chr20:30427077 T/A cg13852791 chr20:30311386 BCL2L1 0.74 7.36 0.41 2.27e-12 Mean corpuscular volume; CESC cis rs10129255 0.957 rs10136560 chr14:107195868 C/G cg23076370 chr14:107095027 NA -0.45 -5.31 -0.31 2.34e-7 Kawasaki disease; CESC cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg20503657 chr10:835505 NA 0.76 7.78 0.43 1.65e-13 Eosinophil percentage of granulocytes; CESC cis rs56036086 0.877 rs55958053 chr22:50647448 T/G cg16473166 chr22:50639996 SELO 0.64 5.13 0.3 5.64e-7 Platelet count;Plateletcrit; CESC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg18230493 chr5:56204884 C5orf35 0.8 9.57 0.51 8.02e-19 Initial pursuit acceleration; CESC cis rs16854884 0.633 rs6779321 chr3:143736676 T/C cg06585982 chr3:143692056 C3orf58 0.5 6.7 0.38 1.26e-10 Economic and political preferences (feminism/equality); CESC cis rs7095944 0.614 rs1055256 chr10:126446592 A/G cg08799069 chr10:126477246 METTL10 -0.35 -5.16 -0.3 4.81e-7 Asthma; CESC cis rs9815354 0.716 rs76313799 chr3:41931751 A/C cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC trans rs79527984 0.618 rs35526560 chr7:71741232 C/G cg12318501 chr22:50919512 ADM2 -0.33 -6.11 -0.35 3.45e-9 Intelligence (multi-trait analysis); CESC cis rs10089 1.000 rs4836367 chr5:127482592 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.51 0.54 8.08e-22 Ileal carcinoids; CESC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.39 0.41 1.97e-12 Electroencephalogram traits; CESC cis rs2479724 0.868 rs2249703 chr6:41814760 A/G cg08135965 chr6:41755394 TOMM6 0.42 5.76 0.33 2.38e-8 Menarche (age at onset); CESC cis rs9362426 0.708 rs7753821 chr6:88100010 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.51 6.11 0.35 3.49e-9 Depressive episodes in bipolar disorder; CESC cis rs4919087 0.532 rs56189004 chr10:99086632 A/G cg25902810 chr10:99078978 FRAT1 -0.49 -5.39 -0.31 1.55e-7 Monocyte count; CESC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg08859206 chr1:53392774 SCP2 -0.6 -8.01 -0.44 3.63e-14 Monocyte count; CESC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg12963246 chr6:28129442 ZNF389 0.51 7.03 0.4 1.8e-11 Depression; CESC cis rs7772486 0.754 rs13214277 chr6:146136125 G/T cg23711669 chr6:146136114 FBXO30 1.02 15.98 0.7 1.02e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs12136530 0.625 rs4912086 chr1:19730181 A/G cg01832549 chr1:19774989 CAPZB -0.44 -6.27 -0.36 1.42e-9 Lead levels in blood; CESC cis rs12348691 0.503 rs7048394 chr9:100605433 T/C cg13688889 chr9:100608707 NA -0.89 -13.55 -0.64 3.84e-32 Alopecia areata; CESC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg22920501 chr2:26401640 FAM59B -0.67 -8.04 -0.44 3.04e-14 Gut microbiome composition (summer); CESC cis rs881375 0.678 rs10760129 chr9:123700183 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.52 0.42 8.42e-13 Rheumatoid arthritis; CESC cis rs2455799 0.573 rs2455834 chr3:15753641 A/G cg16303742 chr3:15540471 COLQ -0.4 -6.29 -0.36 1.29e-9 Mean platelet volume; CESC cis rs7809950 0.678 rs13230144 chr7:106909172 T/C cg23024343 chr7:107201750 COG5 -0.55 -6.91 -0.39 3.58e-11 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22762088 chr20:33581493 MYH7B 0.47 7.12 0.4 9.99e-12 Fibrinogen levels; CESC cis rs7647973 1.000 rs74471041 chr3:49542543 T/G cg07636037 chr3:49044803 WDR6 -0.72 -10.25 -0.53 5.58e-21 Menarche (age at onset); CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.44 -6.23 -0.36 1.79e-9 Electroencephalogram traits; CESC cis rs7772486 0.790 rs1062067 chr6:146207563 A/G cg23711669 chr6:146136114 FBXO30 0.92 13.35 0.63 1.96e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs2933343 0.621 rs789242 chr3:128585707 T/C cg11901034 chr3:128598214 ACAD9 -0.37 -5.53 -0.32 7.56e-8 IgG glycosylation; CESC cis rs11098499 0.779 rs6815934 chr4:120267310 T/C cg09307838 chr4:120376055 NA 0.76 10.03 0.52 2.87e-20 Corneal astigmatism; CESC cis rs1153858 1.000 rs7164602 chr15:45671325 A/G cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs447 1.000 rs6964546 chr7:83750271 T/C cg22846510 chr7:83753280 SEMA3A -0.45 -5.67 -0.33 3.8e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs1814175 0.645 rs28549248 chr11:50042740 C/T cg03929089 chr4:120376271 NA -0.91 -14.92 -0.68 5.78e-37 Height; CESC cis rs8077577 0.708 rs2290504 chr17:18136988 T/C cg16794390 chr17:18148240 FLII -0.43 -6.49 -0.37 4.23e-10 Obesity-related traits; CESC cis rs9787249 0.533 rs1883648 chr1:40246535 T/G cg02773041 chr1:40204384 PPIE 0.39 5.6 0.33 5.33e-8 Blood protein levels; CESC cis rs9287719 0.967 rs12995159 chr2:10753323 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg27170947 chr2:26402098 FAM59B -0.58 -6.85 -0.39 5.18e-11 Gut microbiome composition (summer); CESC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg13902645 chr11:5959945 NA -0.67 -9.54 -0.51 9.62e-19 DNA methylation (variation); CESC cis rs17253792 0.822 rs10137364 chr14:56059987 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.83 6.18 0.36 2.36e-9 Putamen volume; CESC cis rs6842047 0.901 rs2102575 chr4:187131504 G/A cg09526685 chr4:187126073 CYP4V2 0.72 5.85 0.34 1.48e-8 Blood protein levels; CESC cis rs10129255 0.518 rs12590732 chr14:107187851 C/T cg07958169 chr14:107095056 NA 0.53 8.32 0.46 4.69e-15 Kawasaki disease; CESC cis rs9556958 0.708 rs4772092 chr13:99166614 A/G cg20750642 chr13:99100586 FARP1 0.36 5.96 0.34 7.87e-9 Educational attainment (years of education); CESC cis rs782590 0.967 rs10496050 chr2:55806313 C/T cg18811423 chr2:55921094 PNPT1 0.79 12.77 0.62 2.03e-29 Metabolic syndrome; CESC cis rs6120849 0.754 rs752448 chr20:33592248 C/T cg24642439 chr20:33292090 TP53INP2 0.67 6.62 0.38 1.94e-10 Protein C levels; CESC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg17971929 chr21:40555470 PSMG1 -0.55 -7.1 -0.4 1.15e-11 Menarche (age at onset); CESC cis rs9291683 0.546 rs12504565 chr4:10045145 G/A cg00071950 chr4:10020882 SLC2A9 0.81 13.65 0.64 1.7e-32 Bone mineral density; CESC cis rs11638352 1.000 rs12900237 chr15:44330810 A/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.65 -6.07 -0.35 4.52e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs10504229 0.679 rs6474100 chr8:58031161 G/A cg22535103 chr8:58192502 C8orf71 -0.61 -6.86 -0.39 4.87e-11 Developmental language disorder (linguistic errors); CESC cis rs3125734 0.633 rs7100297 chr10:63985100 T/C cg09941381 chr10:64027924 RTKN2 -0.31 -5.11 -0.3 6.19e-7 Rheumatoid arthritis; CESC cis rs728616 0.558 rs17616958 chr10:82137461 A/G cg05935833 chr10:81318306 SFTPA2 -0.46 -5.66 -0.33 3.97e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs1707322 0.721 rs11211158 chr1:46132850 C/G cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1728785 0.818 rs1728772 chr16:68584526 C/T cg02972257 chr16:68554789 NA -0.54 -6.27 -0.36 1.45e-9 Ulcerative colitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11922371 chr17:48226442 PPP1R9B -0.42 -6.14 -0.35 3e-9 Gambling; CESC cis rs12479064 0.724 rs4851203 chr2:99986932 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.63 -7.43 -0.42 1.53e-12 Chronic sinus infection; CESC cis rs818427 0.896 rs712662 chr5:112222694 C/G cg07820702 chr5:112228657 REEP5 0.44 5.46 0.32 1.08e-7 Total body bone mineral density; CESC cis rs1143633 0.566 rs2708932 chr2:113690675 C/A cg12858261 chr2:113808755 IL1F8 -0.44 -5.38 -0.31 1.64e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs6032067 0.929 rs6017504 chr20:43818920 G/A cg10761708 chr20:43804764 PI3 0.53 6.39 0.37 7.37e-10 Blood protein levels; CESC cis rs11204677 1 rs11204677 chr1:150574695 C/G cg13175981 chr1:150552382 MCL1 0.73 10.74 0.55 1.47e-22 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs2243480 1.000 rs316325 chr7:65609518 G/A cg18252515 chr7:66147081 NA -1.41 -14.48 -0.66 2.11e-35 Diabetic kidney disease; CESC trans rs853679 0.607 rs71559070 chr6:28038929 G/A cg06606381 chr12:133084897 FBRSL1 -1.11 -8.0 -0.44 3.78e-14 Depression; CESC cis rs7605827 0.930 rs6749663 chr2:15529705 T/G cg19274914 chr2:15703543 NA 0.35 6.36 0.36 8.85e-10 Educational attainment (years of education); CESC cis rs6540556 0.723 rs12060420 chr1:209906819 T/G cg23920097 chr1:209922102 NA -0.39 -5.06 -0.3 7.99e-7 Red blood cell count; CESC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg18876405 chr7:65276391 NA -0.57 -7.41 -0.41 1.66e-12 Aortic root size; CESC trans rs12316797 0.708 rs12296488 chr12:43130547 A/G cg08862033 chr2:6120613 LOC400940 -0.51 -6.24 -0.36 1.73e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg18904891 chr8:8559673 CLDN23 0.73 8.39 0.46 2.86e-15 Obesity-related traits; CESC cis rs3733585 0.605 rs56178126 chr4:10123581 C/T cg11266682 chr4:10021025 SLC2A9 -0.57 -10.21 -0.53 7.4e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1270639 0.778 rs2530403 chr7:157445639 C/T cg13357408 chr7:157437802 PTPRN2 0.61 7.15 0.4 8.33e-12 Colorectal cancer; CESC cis rs9914578 1.000 rs9915112 chr17:2007826 A/G cg16513277 chr17:2031491 SMG6 -0.57 -6.62 -0.38 1.99e-10 Body mass index; CESC cis rs12477438 0.834 rs1563108 chr2:99701153 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -10.21 -0.53 7.64e-21 Chronic sinus infection; CESC cis rs1003719 0.715 rs2156078 chr21:38546473 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.98 -0.44 4.49e-14 Eye color traits; CESC trans rs4843747 0.671 rs72818540 chr16:88078988 C/T cg26811252 chr16:29126840 RRN3P2 0.7 9.84 0.52 1.11e-19 Menopause (age at onset); CESC trans rs8073060 0.544 rs225274 chr17:33971221 C/T cg19694781 chr19:47549865 TMEM160 0.71 7.51 0.42 9.29e-13 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg01411255 chr17:61851458 DDX42;CCDC47 -1.09 -19.45 -0.77 5.73e-53 Height; CESC cis rs1568889 0.877 rs34351528 chr11:28304293 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.72 8.6 0.47 6.92e-16 Bipolar disorder; CESC cis rs7267005 1.000 rs7272202 chr20:34489669 A/G cg17201900 chr20:34330562 RBM39 -0.97 -5.21 -0.3 3.84e-7 Response to paliperidone in schizophrenia (Multivariate); CESC cis rs7524258 0.868 rs1304712 chr1:7270538 C/T cg07173049 chr1:7289937 CAMTA1 0.4 5.95 0.34 8.65e-9 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs796364 1.000 rs769949 chr2:200729558 A/G cg23649088 chr2:200775458 C2orf69 0.54 5.1 0.3 6.38e-7 Schizophrenia; CESC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg18032046 chr6:28092343 ZSCAN16 -0.55 -5.98 -0.34 7.09e-9 Parkinson's disease; CESC cis rs9612 1.000 rs2277745 chr19:44259077 C/T cg08581076 chr19:44259116 C19orf61 0.63 7.37 0.41 2.21e-12 Exhaled nitric oxide output; CESC cis rs4727027 0.834 rs7811446 chr7:148773226 G/T cg23583168 chr7:148888333 NA -0.78 -11.73 -0.58 7.14e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg07701084 chr6:150067640 NUP43 0.46 6.48 0.37 4.5e-10 Lung cancer; CESC cis rs4924935 1.000 rs35341640 chr17:18818228 G/A cg26378065 chr17:18585709 ZNF286B -0.52 -6.4 -0.37 6.95e-10 Pancreatic cancer; CESC cis rs1218582 0.688 rs58629129 chr1:154910930 T/C cg09359103 chr1:154839909 KCNN3 -0.59 -10.25 -0.53 5.57e-21 Prostate cancer; CESC cis rs8017423 0.647 rs12895269 chr14:90822430 T/C cg14092571 chr14:90743983 NA 0.44 6.77 0.38 8.12e-11 Mortality in heart failure; CESC cis rs711245 0.545 rs848617 chr2:36811298 G/C cg09467607 chr2:36825704 FEZ2 0.55 10.25 0.53 5.65e-21 Height; CESC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg01763666 chr17:80159506 CCDC57 0.37 5.16 0.3 4.92e-7 Life satisfaction; CESC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg22105103 chr4:187893119 NA 0.51 7.61 0.42 4.66e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs4664308 0.658 rs12987602 chr2:160960788 G/T cg03641300 chr2:160917029 PLA2R1 -0.44 -6.23 -0.36 1.86e-9 Idiopathic membranous nephropathy; CESC cis rs4722166 0.695 rs6946509 chr7:22809490 T/C cg13104385 chr7:22767384 IL6 0.37 5.51 0.32 8.64e-8 Lung cancer; CESC cis rs9715521 0.935 rs56025348 chr4:59836741 T/G cg11281224 chr4:60001000 NA -0.51 -6.6 -0.38 2.29e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1355223 1.000 rs12792532 chr11:34765782 G/T cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.09 -0.35 3.98e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs454510 0.816 rs838987 chr1:120176127 A/G cg16322792 chr1:120165303 ZNF697 0.46 7.31 0.41 3.2e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs36051895 0.632 rs12001334 chr9:5152604 C/A cg02405213 chr9:5042618 JAK2 -0.52 -6.44 -0.37 5.58e-10 Pediatric autoimmune diseases; CESC cis rs9399135 0.967 rs9389254 chr6:135330709 C/T cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.79 -0.55 9.49e-23 Alzheimer's disease; CESC cis rs12579753 0.672 rs4509857 chr12:82268017 C/T cg23701643 chr12:82153290 PPFIA2 -0.35 -5.28 -0.31 2.76e-7 Resting heart rate; CESC cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.13 -0.4 9.42e-12 Personality dimensions; CESC cis rs1355223 0.902 rs12802120 chr11:34747650 G/A cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.07 -0.35 4.29e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs8114671 0.562 rs2378294 chr20:33500378 G/A cg07148914 chr20:33460835 GGT7 0.46 6.12 0.35 3.43e-9 Height; CESC cis rs9399401 0.667 rs12213892 chr6:142702234 A/G cg04461802 chr6:142623433 GPR126 0.36 5.4 0.31 1.52e-7 Chronic obstructive pulmonary disease; CESC cis rs8005677 0.962 rs11157931 chr14:23403193 A/C cg01529538 chr14:23388837 RBM23 0.5 6.74 0.38 9.9e-11 Cognitive ability (multi-trait analysis); CESC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.34 -0.31 1.99e-7 Lung cancer; CESC cis rs60733400 0.817 rs4648657 chr1:2560735 A/G cg20673091 chr1:2541236 MMEL1 -0.47 -7.78 -0.43 1.64e-13 Multiple sclerosis; CESC cis rs3106136 0.872 rs10033662 chr4:95239462 G/A cg11021082 chr4:95130006 SMARCAD1 0.44 6.49 0.37 4.25e-10 Capecitabine sensitivity; CESC cis rs2228479 0.867 rs75110337 chr16:89962635 C/A cg06558623 chr16:89946397 TCF25 1.05 8.66 0.47 4.66e-16 Skin colour saturation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05780637 chr2:239989132 HDAC4 0.53 7.06 0.4 1.43e-11 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13248847 chr17:7137857 DVL2 0.65 8.13 0.45 1.68e-14 Gut microbiome composition (summer); CESC cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg25985355 chr7:65971099 NA 0.32 5.27 0.31 2.78e-7 Aortic root size; CESC cis rs1790761 0.587 rs4930431 chr11:67294308 C/T cg24690094 chr11:67383802 NA -0.36 -6.34 -0.36 9.92e-10 Mean corpuscular volume; CESC cis rs12681288 0.578 rs56702775 chr8:968860 G/A cg04851639 chr8:1020857 NA -0.31 -6.08 -0.35 4.21e-9 Schizophrenia; CESC cis rs3857536 0.776 rs9342535 chr6:66932963 C/T cg07460842 chr6:66804631 NA -0.42 -5.36 -0.31 1.8e-7 Blood trace element (Cu levels); CESC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg05234568 chr11:5960015 NA -0.62 -7.01 -0.4 1.97e-11 DNA methylation (variation); CESC cis rs12930096 0.938 rs8048558 chr16:11678332 G/A cg07439791 chr16:11680400 LITAF 0.61 5.63 0.33 4.68e-8 QT interval; CESC cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg11752832 chr7:134001865 SLC35B4 0.53 6.85 0.39 5.2e-11 Mean platelet volume; CESC cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg19729930 chr2:74357872 NA 0.86 12.95 0.62 4.69e-30 Gestational age at birth (maternal effect); CESC cis rs7267979 1.000 rs2387884 chr20:25379069 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.45 -0.32 1.13e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg18180107 chr4:99064573 C4orf37 0.4 5.09 0.3 6.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3736485 0.966 rs1031664 chr15:51754897 C/A cg08986416 chr15:51914746 DMXL2 -0.42 -5.35 -0.31 1.93e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2204008 0.555 rs7310307 chr12:38107497 G/T cg13010199 chr12:38710504 ALG10B 0.53 6.43 0.37 5.77e-10 Bladder cancer; CESC trans rs629535 0.821 rs680993 chr8:70050247 G/A cg21567404 chr3:27674614 NA 0.93 11.17 0.57 5.25e-24 Dupuytren's disease; CESC cis rs41271951 0.512 rs12090246 chr1:151107496 G/A cg11822372 chr1:151115635 SEMA6C -0.64 -5.12 -0.3 5.84e-7 Blood protein levels; CESC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg14703610 chr5:56206110 C5orf35 0.54 7.02 0.4 1.83e-11 Coronary artery disease; CESC cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4595586 0.545 rs12831116 chr12:39401456 C/T cg26384229 chr12:38710491 ALG10B 0.63 8.92 0.48 7.92e-17 Morning vs. evening chronotype; CESC cis rs1003719 0.680 rs3992 chr21:38505969 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.47 -0.46 1.69e-15 Eye color traits; CESC cis rs9549260 0.755 rs7990923 chr13:41215972 A/G cg21288729 chr13:41239152 FOXO1 0.65 8.62 0.47 6.27e-16 Red blood cell count; CESC cis rs3740713 0.920 rs73438659 chr11:18455953 A/G cg23797887 chr11:18477753 LDHAL6A -0.53 -5.27 -0.31 2.89e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg26338869 chr17:61819248 STRADA 0.68 8.89 0.48 9.81e-17 Prudent dietary pattern; CESC cis rs8014204 0.762 rs8016389 chr14:75287554 T/C cg08847533 chr14:75593920 NEK9 0.41 5.3 0.31 2.42e-7 Caffeine consumption; CESC cis rs7520050 0.778 rs3013597 chr1:46128356 C/A cg06784218 chr1:46089804 CCDC17 0.33 6.06 0.35 4.54e-9 Red blood cell count;Reticulocyte count; CESC cis rs3820068 0.603 rs1980607 chr1:15975237 A/G cg13390004 chr1:15929781 NA 0.34 5.58 0.32 6.07e-8 Systolic blood pressure; CESC cis rs422421 1.000 rs434434 chr5:176516953 A/G cg00618323 chr5:176515533 FGFR4 0.41 5.23 0.31 3.5e-7 Height; CESC cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg08109568 chr15:31115862 NA -0.69 -9.06 -0.49 2.88e-17 Huntington's disease progression; CESC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg05564831 chr3:52568323 NT5DC2 0.45 7.02 0.4 1.83e-11 Bipolar disorder; CESC cis rs2243480 1.000 rs778704 chr7:65863467 T/C cg18252515 chr7:66147081 NA -1.39 -14.18 -0.66 2.5e-34 Diabetic kidney disease; CESC cis rs9287719 0.649 rs58633964 chr2:10736382 T/G cg00105475 chr2:10696890 NA 0.37 5.22 0.31 3.6e-7 Prostate cancer; CESC cis rs11098499 0.865 rs4001305 chr4:120359236 G/T cg24375607 chr4:120327624 NA 0.46 5.77 0.33 2.18e-8 Corneal astigmatism; CESC cis rs11958404 0.932 rs72816574 chr5:157429882 T/C cg05962755 chr5:157440814 NA 0.62 6.53 0.37 3.41e-10 IgG glycosylation; CESC cis rs2885135 0.559 rs1148455 chr1:13914230 A/G cg04886857 chr1:13914270 PDPN 0.33 5.6 0.33 5.38e-8 Response to cytadine analogues (cytosine arabinoside); CESC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg11301795 chr4:187892539 NA -0.57 -8.88 -0.48 1.02e-16 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.846 rs7773939 chr6:145927384 C/T cg23711669 chr6:146136114 FBXO30 -0.83 -12.02 -0.59 7.45e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs6500395 0.926 rs1039343 chr16:48577507 T/G cg04672837 chr16:48644449 N4BP1 0.49 5.98 0.34 7.28e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9894429 1.000 rs4074915 chr17:79579230 G/A cg13777783 chr17:79615861 NA 0.35 5.78 0.33 2.09e-8 Eye color traits; CESC cis rs6598955 0.671 rs57386998 chr1:26569821 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.38 5.44 0.32 1.21e-7 Obesity-related traits; CESC cis rs7072216 0.763 rs6584202 chr10:100170383 G/A cg26618903 chr10:100175079 PYROXD2 -0.36 -5.59 -0.32 5.65e-8 Metabolite levels; CESC cis rs4843747 0.671 rs28679286 chr16:88106307 C/T cg03395651 chr16:88107091 BANP 0.46 5.36 0.31 1.85e-7 Menopause (age at onset); CESC cis rs889398 0.774 rs6499263 chr16:69890149 T/C cg09409435 chr16:70099608 PDXDC2 0.42 5.27 0.31 2.9e-7 Body mass index; CESC cis rs9911578 0.967 rs4932693 chr17:57110327 T/C cg12560992 chr17:57184187 TRIM37 -1.01 -17.65 -0.74 1.26e-46 Intelligence (multi-trait analysis); CESC cis rs8077577 0.895 rs3088233 chr17:18112675 C/T cg16794390 chr17:18148240 FLII 0.41 5.64 0.33 4.37e-8 Obesity-related traits; CESC cis rs35110281 0.632 rs9306160 chr21:45107562 T/C cg04455712 chr21:45112962 RRP1B 0.47 7.2 0.4 6.15e-12 Mean corpuscular volume; CESC cis rs754466 0.651 rs10824584 chr10:79625947 G/A cg17075019 chr10:79541650 NA -0.85 -13.12 -0.63 1.25e-30 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC cis rs2046867 0.862 rs6805234 chr3:72829869 A/G cg25664220 chr3:72788482 NA -0.38 -5.74 -0.33 2.54e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs831574 0.614 rs6806547 chr3:63893477 G/T cg15342441 chr3:63893510 ATXN7 -0.43 -5.41 -0.32 1.42e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.73 -10.11 -0.53 1.56e-20 Systemic lupus erythematosus; CESC cis rs9300255 0.602 rs941305 chr12:123715266 T/C cg00376283 chr12:123451042 ABCB9 0.72 8.84 0.48 1.34e-16 Neutrophil percentage of white cells; CESC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg10351095 chr21:47802916 PCNT -0.45 -6.14 -0.35 2.98e-9 Testicular germ cell tumor; CESC cis rs250677 0.958 rs36068 chr5:148417512 C/T cg18129178 chr5:148520854 ABLIM3 -0.52 -5.8 -0.34 1.86e-8 Breast cancer; CESC cis rs10788972 0.815 rs1981039 chr1:54555405 T/A cg25741118 chr1:54482237 LDLRAD1 -0.22 -5.25 -0.31 3.19e-7 Parkinson disease and lewy body pathology; CESC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg17911788 chr17:44343683 NA 0.42 6.52 0.37 3.45e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1153858 1.000 rs11858495 chr15:45637662 A/G cg14582100 chr15:45693742 SPATA5L1 -0.42 -5.75 -0.33 2.51e-8 Homoarginine levels; CESC trans rs875971 0.628 rs6974355 chr7:65841981 A/G cg26939375 chr7:64535504 NA 0.65 8.48 0.46 1.55e-15 Aortic root size; CESC cis rs11642862 0.901 rs11647243 chr16:30965308 G/A cg02466173 chr16:30829666 NA -0.57 -5.21 -0.3 3.81e-7 Tonsillectomy; CESC cis rs57709857 0.957 rs56300324 chr8:38180561 T/G cg01506891 chr8:38243824 LETM2 0.48 5.03 0.3 9.22e-7 Autism spectrum disorder or schizophrenia; CESC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg18876405 chr7:65276391 NA 0.5 6.85 0.39 5.28e-11 Aortic root size; CESC cis rs4808199 0.948 rs2023883 chr19:19405480 G/A cg03709012 chr19:19516395 GATAD2A 1.09 12.03 0.59 6.68e-27 Nonalcoholic fatty liver disease; CESC cis rs1881744 1.000 rs11183943 chr12:47810498 G/T cg18786123 chr12:47787067 NA 0.68 5.22 0.31 3.57e-7 Metabolite levels (HVA/5-HIAA ratio); CESC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.57 0.37 2.59e-10 Bipolar disorder; CESC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg09491104 chr22:46646882 C22orf40 -0.52 -6.42 -0.37 6.22e-10 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg22535103 chr8:58192502 C8orf71 -1.06 -11.56 -0.58 2.66e-25 Developmental language disorder (linguistic errors); CESC cis rs2050392 0.624 rs303450 chr10:30725337 C/A cg25182066 chr10:30743637 MAP3K8 -0.45 -5.83 -0.34 1.6e-8 Inflammatory bowel disease; CESC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs9467711 0.606 rs9393710 chr6:26367833 A/G cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs684232 0.583 rs10521106 chr17:510707 C/T cg15660573 chr17:549704 VPS53 -0.79 -11.68 -0.58 1.08e-25 Prostate cancer; CESC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg00166722 chr3:10149974 C3orf24 0.55 7.09 0.4 1.21e-11 Alzheimer's disease; CESC cis rs10208940 0.920 rs35118992 chr2:68699460 G/A cg12452813 chr2:68675892 NA 0.52 5.24 0.31 3.26e-7 Urate levels in lean individuals; CESC cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg26597838 chr10:835615 NA 0.66 5.91 0.34 1.04e-8 Eosinophil percentage of granulocytes; CESC cis rs1448094 0.817 rs61929421 chr12:86342330 T/C cg02569458 chr12:86230093 RASSF9 0.42 5.98 0.34 7.33e-9 Major depressive disorder; CESC cis rs10463316 0.608 rs7700423 chr5:150769155 C/T cg03212797 chr5:150827313 SLC36A1 -0.45 -5.88 -0.34 1.24e-8 Metabolite levels (Pyroglutamine); CESC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg18180107 chr4:99064573 C4orf37 0.45 5.51 0.32 8.52e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7829975 0.511 rs2976906 chr8:8342415 A/T cg06636001 chr8:8085503 FLJ10661 0.42 5.13 0.3 5.71e-7 Mood instability; CESC cis rs7772486 0.790 rs4896852 chr6:146284621 T/C cg05347473 chr6:146136440 FBXO30 -0.56 -7.17 -0.4 7.61e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs3862030 0.839 rs12570859 chr10:104257226 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.37 -5.23 -0.31 3.38e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs2749592 0.588 rs2504144 chr10:38383525 C/T cg25517755 chr10:38738941 LOC399744 -0.43 -5.13 -0.3 5.53e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs763121 0.819 rs5757169 chr22:39003495 G/A cg06544989 chr22:39130855 UNC84B 0.51 9.34 0.5 4.01e-18 Menopause (age at onset); CESC cis rs713587 0.563 rs7605335 chr2:25109317 G/A cg01884057 chr2:25150051 NA 0.34 6.44 0.37 5.53e-10 Body mass index in non-asthmatics; CESC cis rs7847628 0.550 rs12343516 chr9:123603469 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.78 12.61 0.61 7.2e-29 Birth weight; CESC cis rs314370 1.000 rs12705089 chr7:100465355 C/T cg10426581 chr7:100472382 SRRT 0.85 8.1 0.45 1.96e-14 Resting heart rate; CESC cis rs6088590 0.542 rs6059956 chr20:33220070 A/G cg24642439 chr20:33292090 TP53INP2 0.64 8.53 0.46 1.12e-15 Coronary artery disease; CESC cis rs11792861 0.781 rs2297581 chr9:111755008 C/T cg13535736 chr9:111863775 C9orf5 -0.47 -6.2 -0.36 2.17e-9 Menarche (age at onset); CESC cis rs6740322 0.895 rs6760797 chr2:43559612 G/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.7 -7.29 -0.41 3.68e-12 Coronary artery disease; CESC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg10691866 chr7:65817282 TPST1 0.31 5.23 0.31 3.43e-7 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20250874 chr13:47127354 LRCH1 -0.47 -6.71 -0.38 1.15e-10 Gambling; CESC cis rs34779708 0.966 rs11592567 chr10:35409369 C/T cg04310649 chr10:35416472 CREM -0.52 -6.25 -0.36 1.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs72781680 1.000 rs72788286 chr2:24098321 A/C cg20701182 chr2:24300061 SF3B14 0.62 5.68 0.33 3.54e-8 Lymphocyte counts; CESC cis rs6500395 0.925 rs9933148 chr16:48672099 C/T cg04672837 chr16:48644449 N4BP1 0.51 6.28 0.36 1.35e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs8060686 0.920 rs73594556 chr16:67925435 G/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.46 -0.37 4.94e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs9611565 0.559 rs9611619 chr22:41986714 C/T cg17376030 chr22:41985996 PMM1 0.81 8.45 0.46 1.98e-15 Vitiligo; CESC cis rs6570726 0.791 rs448939 chr6:145808320 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.32 0.36 1.12e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs9768139 0.901 rs56113702 chr7:158117938 C/T cg24154853 chr7:158122151 PTPRN2 -0.38 -5.96 -0.34 8.14e-9 Calcium levels; CESC cis rs6991838 0.584 rs16932245 chr8:66510045 A/C cg13398993 chr8:66546079 ARMC1 -0.47 -5.59 -0.32 5.56e-8 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04618842 chr12:57472555 TMEM194A -0.57 -6.95 -0.39 2.84e-11 Gut microbiome composition (summer); CESC cis rs514406 0.893 rs1242317 chr1:53414766 T/C cg24675658 chr1:53192096 ZYG11B -0.53 -6.42 -0.37 6.12e-10 Monocyte count; CESC cis rs9902453 0.868 rs9890075 chr17:28470464 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.29 0.45 5.59e-15 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06090630 chr16:2827139 TCEB2 0.57 6.24 0.36 1.76e-9 Gut microbiome composition (summer); CESC cis rs9287719 0.967 rs715247 chr2:10736291 A/G cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC trans rs116095464 0.558 rs10043002 chr5:226753 G/A cg00938859 chr5:1591904 SDHAP3 0.62 6.74 0.38 9.67e-11 Breast cancer; CESC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg13902645 chr11:5959945 NA -0.67 -7.71 -0.43 2.52e-13 DNA methylation (variation); CESC cis rs116095464 0.614 rs62344339 chr5:252995 T/G cg22496380 chr5:211416 CCDC127 -0.73 -8.39 -0.46 2.99e-15 Breast cancer; CESC cis rs7044106 0.791 rs10984994 chr9:123478769 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.64 -8.72 -0.47 3.05e-16 Hip circumference adjusted for BMI; CESC cis rs6495122 0.699 rs3784789 chr15:75082552 C/G cg14664628 chr15:75095509 CSK -0.67 -9.29 -0.5 5.99e-18 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg16339924 chr4:17578868 LAP3 0.51 6.57 0.37 2.67e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12478296 0.786 rs13409307 chr2:242995499 G/C cg06360820 chr2:242988706 NA -0.74 -9.37 -0.5 3.4e-18 Obesity-related traits; CESC cis rs9858542 0.953 rs71324979 chr3:49619651 T/C cg07274523 chr3:49395745 GPX1 0.64 8.11 0.45 1.85e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg08736216 chr1:53307985 ZYG11A -0.41 -6.9 -0.39 3.83e-11 Monocyte count; CESC cis rs73001065 0.901 rs73004933 chr19:19675696 C/T cg03709012 chr19:19516395 GATAD2A 0.95 5.74 0.33 2.62e-8 LDL cholesterol; CESC cis rs8141529 0.956 rs132539 chr22:29304253 C/T cg15103426 chr22:29168792 CCDC117 0.53 6.27 0.36 1.44e-9 Lymphocyte counts; CESC cis rs55823223 0.564 rs936391 chr17:73847799 A/G cg06969265 chr17:73775802 H3F3B -0.48 -5.35 -0.31 1.92e-7 Psoriasis; CESC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg05863683 chr7:1912471 MAD1L1 0.4 5.9 0.34 1.08e-8 Bipolar disorder and schizophrenia; CESC cis rs7267979 1.000 rs2482937 chr20:25340786 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -16.6 -0.71 6.28e-43 Liver enzyme levels (alkaline phosphatase); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg26532042 chr19:49468557 FTL 0.47 6.09 0.35 3.95e-9 Breast cancer;Type 2 diabetes; CESC cis rs6430585 0.536 rs3213892 chr2:136552517 G/A cg07169764 chr2:136633963 MCM6 1.3 17.95 0.74 1.12e-47 Corneal structure; CESC cis rs3008870 0.727 rs2862729 chr1:67500828 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.61 7.95 0.44 5.54e-14 Lymphocyte percentage of white cells; CESC cis rs2932538 0.961 rs6690292 chr1:113188419 C/T cg22162597 chr1:113214053 CAPZA1 -0.45 -6.1 -0.35 3.79e-9 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs28647808 0.786 rs4962137 chr9:136256826 G/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs1018836 0.923 rs9643308 chr8:91625399 A/C cg16814680 chr8:91681699 NA -0.72 -9.98 -0.52 3.92e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2050392 0.590 rs17547917 chr10:30718303 G/A cg18806716 chr10:30721971 MAP3K8 -0.62 -9.21 -0.49 1.01e-17 Inflammatory bowel disease; CESC cis rs7588746 0.571 rs4673891 chr2:201156362 C/G cg23649088 chr2:200775458 C2orf69 -0.43 -5.18 -0.3 4.32e-7 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg13628971 chr7:2884303 GNA12 0.6 7.78 0.43 1.66e-13 Height; CESC cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg10523679 chr1:76189770 ACADM -0.6 -6.31 -0.36 1.2e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7917772 0.636 rs4418737 chr10:104525123 A/G cg04362960 chr10:104952993 NT5C2 0.45 5.11 0.3 6.07e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg04944784 chr2:26401820 FAM59B 0.96 10.55 0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.52 0.32 7.94e-8 Bipolar disorder; CESC cis rs7086627 0.515 rs4933390 chr10:82213081 A/C cg03267442 chr10:82210566 NA -0.34 -5.58 -0.32 6.06e-8 Post bronchodilator FEV1; CESC cis rs13191362 1.000 rs13206253 chr6:163166902 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.66 6.88 0.39 4.28e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9487051 0.676 rs4383852 chr6:109594475 G/A cg21918786 chr6:109611834 NA -0.37 -5.41 -0.32 1.39e-7 Reticulocyte fraction of red cells; CESC cis rs12136530 0.636 rs4244001 chr1:19734368 C/T cg01832549 chr1:19774989 CAPZB -0.44 -6.25 -0.36 1.64e-9 Lead levels in blood; CESC cis rs6088580 0.524 rs6142210 chr20:33223012 C/T cg24642439 chr20:33292090 TP53INP2 -0.5 -5.97 -0.34 7.64e-9 Glomerular filtration rate (creatinine); CESC cis rs72627123 0.530 rs79371463 chr14:74474856 T/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.79 5.8 0.34 1.92e-8 Morning vs. evening chronotype; CESC trans rs116095464 0.558 rs6878061 chr5:223072 A/G cg00938859 chr5:1591904 SDHAP3 0.6 6.66 0.38 1.55e-10 Breast cancer; CESC cis rs3733585 0.781 rs13103879 chr4:9972879 T/C cg02734326 chr4:10020555 SLC2A9 -0.45 -6.66 -0.38 1.55e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3762637 1.000 rs28497203 chr3:122231819 T/C cg24169773 chr3:122142474 KPNA1 -0.59 -6.91 -0.39 3.61e-11 LDL cholesterol levels; CESC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg26818010 chr10:134567672 INPP5A -0.65 -8.06 -0.44 2.7e-14 Migraine; CESC trans rs61931739 0.500 rs6488215 chr12:34434803 A/T cg26384229 chr12:38710491 ALG10B 0.54 7.46 0.42 1.25e-12 Morning vs. evening chronotype; CESC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg08859206 chr1:53392774 SCP2 0.61 8.32 0.46 4.68e-15 Monocyte count; CESC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg18404041 chr3:52824283 ITIH1 -0.4 -6.73 -0.38 1.07e-10 Bipolar disorder; CESC cis rs67460515 0.500 rs9812507 chr3:160723393 G/A cg03342759 chr3:160939853 NMD3 -0.43 -5.4 -0.32 1.45e-7 Parkinson's disease; CESC cis rs3105593 1.000 rs12591751 chr15:50972497 G/A cg08437265 chr15:50716283 USP8 0.46 6.11 0.35 3.5e-9 QT interval; CESC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg18230493 chr5:56204884 C5orf35 -0.72 -8.78 -0.47 2.09e-16 Initial pursuit acceleration; CESC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg27170947 chr2:26402098 FAM59B 0.6 7.08 0.4 1.28e-11 Gut microbiome composition (summer); CESC cis rs8062405 0.964 rs72793809 chr16:28832382 C/T cg08761264 chr16:28874980 SH2B1 -0.47 -5.84 -0.34 1.55e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs10129255 0.957 rs12590667 chr14:107187462 A/G cg23076370 chr14:107095027 NA 0.5 6.49 0.37 4.15e-10 Kawasaki disease; CESC cis rs4474465 0.850 rs10751292 chr11:78242201 C/G cg27205649 chr11:78285834 NARS2 0.44 5.42 0.32 1.33e-7 Alzheimer's disease (survival time); CESC cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg06766960 chr11:133703094 NA -0.38 -5.41 -0.32 1.44e-7 Childhood ear infection; CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg07507251 chr3:52567010 NT5DC2 0.38 7.27 0.41 4.16e-12 Bipolar disorder; CESC trans rs61931739 0.517 rs4104182 chr12:34081343 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.21 0.45 9.64e-15 Morning vs. evening chronotype; CESC cis rs11563648 0.535 rs6467122 chr7:127001087 A/C cg25922125 chr7:127225783 GCC1 -0.42 -5.16 -0.3 4.74e-7 Resting heart rate; CESC cis rs763014 0.931 rs7199839 chr16:636126 T/C cg00802000 chr16:706648 WDR90 -0.41 -6.19 -0.36 2.26e-9 Height; CESC cis rs614226 1.000 rs1614223 chr12:120964043 T/C cg01236616 chr12:121019343 POP5 1.55 19.98 0.78 8.29e-55 Type 1 diabetes nephropathy; CESC cis rs6835098 0.923 rs7671278 chr4:174095769 A/G cg08422745 chr4:174089978 GALNT7 -0.7 -9.22 -0.49 9.26e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs977987 0.843 rs10514396 chr16:75422903 T/C cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.68e-8 Dupuytren's disease; CESC cis rs6088590 1.000 rs2295354 chr20:33356541 T/C cg24642439 chr20:33292090 TP53INP2 0.85 11.78 0.59 4.73e-26 Coronary artery disease; CESC cis rs9611565 0.765 rs132921 chr22:41812044 G/A cg06481639 chr22:41940642 POLR3H 0.58 6.34 0.36 9.76e-10 Vitiligo; CESC cis rs11676348 0.935 rs4674250 chr2:218977531 G/A cg00012203 chr2:219082015 ARPC2 -0.54 -6.92 -0.39 3.37e-11 Ulcerative colitis; CESC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg11764359 chr7:65958608 NA 0.79 9.51 0.5 1.18e-18 Aortic root size; CESC cis rs11997175 0.713 rs4733454 chr8:33651253 C/A ch.8.33884649F chr8:33765107 NA 0.55 6.77 0.38 8.32e-11 Body mass index; CESC cis rs4629180 1.000 rs13031791 chr2:102108790 T/C cg01388757 chr2:102091195 RFX8 0.44 6.75 0.38 9.06e-11 Chronic rhinosinusitis with nasal polyps; CESC trans rs561341 1.000 rs555629 chr17:30294136 T/C cg20587970 chr11:113659929 NA -1.43 -18.65 -0.75 3.85e-50 Hip circumference adjusted for BMI; CESC cis rs7647973 0.600 rs13064780 chr3:49274826 T/G cg02487422 chr3:49467188 NICN1 0.39 5.3 0.31 2.38e-7 Menarche (age at onset); CESC cis rs861020 0.630 rs655712 chr1:210006437 G/A cg05527609 chr1:210001259 C1orf107 0.74 9.67 0.51 3.97e-19 Orofacial clefts; CESC cis rs2290159 1.000 rs2290159 chr3:12628920 G/C cg23032965 chr3:12705835 RAF1 0.49 5.44 0.32 1.22e-7 Cholesterol, total; CESC cis rs6088580 0.634 rs6087588 chr20:33066369 T/C cg06115741 chr20:33292138 TP53INP2 0.45 5.71 0.33 3.09e-8 Glomerular filtration rate (creatinine); CESC cis rs9486719 0.522 rs4839683 chr6:96851933 A/G cg18709589 chr6:96969512 KIAA0776 0.43 5.11 0.3 6.19e-7 Migraine;Coronary artery disease; CESC cis rs6088580 0.634 rs6088488 chr20:32992631 T/C cg08999081 chr20:33150536 PIGU -0.66 -11.72 -0.58 8.03e-26 Glomerular filtration rate (creatinine); CESC cis rs7727544 0.716 rs4594848 chr5:131586598 C/A cg14196790 chr5:131705035 SLC22A5 0.35 5.24 0.31 3.21e-7 Blood metabolite levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12780433 chr3:159481918 SCHIP1 -0.5 -8.11 -0.45 1.85e-14 Gambling; CESC cis rs9896933 0.732 rs590886 chr17:80767350 A/G cg19500275 chr17:80737654 TBCD -0.53 -5.51 -0.32 8.33e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg05347473 chr6:146136440 FBXO30 0.57 7.26 0.41 4.21e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03592283 chr3:44666723 ZNF197 -0.44 -6.21 -0.36 2e-9 Fibrinogen levels; CESC cis rs763121 0.853 rs138706 chr22:39137834 C/G cg06544989 chr22:39130855 UNC84B 0.51 9.64 0.51 4.93e-19 Menopause (age at onset); CESC cis rs6500395 0.963 rs4785528 chr16:48687908 A/C cg04672837 chr16:48644449 N4BP1 -0.51 -6.37 -0.36 8.27e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg02297831 chr4:17616191 MED28 0.61 7.82 0.43 1.23e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7666738 0.830 rs2865989 chr4:99067532 G/A cg05340658 chr4:99064831 C4orf37 0.83 12.82 0.62 1.36e-29 Colonoscopy-negative controls vs population controls; CESC cis rs727505 0.607 rs67454509 chr7:124792500 A/G cg23710748 chr7:124431027 NA -0.4 -6.19 -0.36 2.33e-9 Lewy body disease; CESC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg19592336 chr6:28129416 ZNF389 0.53 6.92 0.39 3.43e-11 Parkinson's disease; CESC cis rs2075371 0.863 rs12707139 chr7:133954153 A/G cg20476274 chr7:133979776 SLC35B4 0.62 8.9 0.48 8.88e-17 Mean platelet volume; CESC cis rs55883249 1.000 rs76964971 chr2:9763904 C/A cg23886495 chr2:9695866 ADAM17 0.61 5.51 0.32 8.64e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs11252926 0.603 rs11252670 chr10:529152 A/G cg03684893 chr10:554711 DIP2C 0.43 6.46 0.37 4.97e-10 Psychosis in Alzheimer's disease; CESC cis rs2072732 0.821 rs10909864 chr1:2948178 T/C cg03976712 chr1:2946727 NA 0.32 5.47 0.32 1.07e-7 Plateletcrit; CESC cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg05340658 chr4:99064831 C4orf37 0.6 8.01 0.44 3.74e-14 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21767207 chr19:36236454 PSENEN;U2AF1L4 0.45 6.14 0.35 2.98e-9 Gut microbiota (bacterial taxa); CESC cis rs34779708 0.931 rs2490663 chr10:35329735 A/G cg04310649 chr10:35416472 CREM 0.5 6.21 0.36 2.07e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.43 -5.18 -0.3 4.43e-7 Total body bone mineral density; CESC cis rs13095912 0.743 rs13076556 chr3:185339575 A/G cg11274856 chr3:185301563 NA 0.37 5.51 0.32 8.61e-8 Systolic blood pressure; CESC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.72 0.38 1.1e-10 Bipolar disorder; CESC cis rs7072216 0.763 rs942803 chr10:100168631 G/T cg26618903 chr10:100175079 PYROXD2 -0.37 -5.73 -0.33 2.79e-8 Metabolite levels; CESC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.89 7.84 0.43 1.08e-13 Depression; CESC cis rs3020736 0.500 rs28791586 chr22:42500483 A/G cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC cis rs3781458 0.803 rs11245321 chr10:126323279 C/T cg20435097 chr10:126320824 FAM53B 0.29 5.31 0.31 2.31e-7 Male-pattern baldness; CESC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs7819412 0.740 rs11250119 chr8:11037034 C/T cg15556689 chr8:8085844 FLJ10661 -0.53 -6.81 -0.39 6.46e-11 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11192808 chr8:101170185 SPAG1 0.62 7.42 0.41 1.58e-12 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg13628971 chr7:2884303 GNA12 0.61 7.39 0.41 1.98e-12 Height; CESC cis rs2180341 0.824 rs9321076 chr6:127655614 G/A cg24812749 chr6:127587940 RNF146 1.07 15.4 0.69 1.16e-38 Breast cancer; CESC cis rs3125734 0.633 rs10761616 chr10:64009076 G/A cg09941381 chr10:64027924 RTKN2 -0.31 -5.2 -0.3 4.09e-7 Rheumatoid arthritis; CESC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg10691866 chr7:65817282 TPST1 0.35 5.81 0.34 1.76e-8 Aortic root size; CESC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg18876405 chr7:65276391 NA 0.68 9.52 0.5 1.16e-18 Aortic root size; CESC trans rs3942852 0.606 rs10734561 chr11:48097480 C/T cg03929089 chr4:120376271 NA -0.54 -6.41 -0.37 6.77e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs11638352 1.000 rs2706481 chr15:44406317 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.62 -5.65 -0.33 4.07e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs7429990 0.965 rs2882668 chr3:47980306 A/G cg11946769 chr3:48343235 NME6 0.42 5.27 0.31 2.78e-7 Educational attainment (years of education); CESC cis rs9811920 0.535 rs793481 chr3:99488742 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.34 -5.44 -0.32 1.19e-7 Axial length; CESC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg11890956 chr21:40555474 PSMG1 -0.94 -15.03 -0.68 2.36e-37 Cognitive function; CESC cis rs2236918 0.932 rs2526697 chr1:242040129 A/G cg17736920 chr1:242011382 EXO1 -0.55 -7.21 -0.4 5.95e-12 Menopause (age at onset); CESC trans rs7980799 0.682 rs10844612 chr12:33603676 T/C cg26384229 chr12:38710491 ALG10B -0.56 -8.03 -0.44 3.21e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs11264213 0.901 rs72661623 chr1:36398368 G/A cg27506609 chr1:36549197 TEKT2 0.66 5.59 0.32 5.62e-8 Schizophrenia; CESC cis rs1957429 0.901 rs6573583 chr14:65351211 G/T cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08108911 chr1:157015297 ARHGEF11 -0.41 -6.18 -0.35 2.46e-9 Fibrinogen levels; CESC cis rs2710642 0.962 rs4671051 chr2:63032696 A/T cg17519650 chr2:63277830 OTX1 -0.53 -6.88 -0.39 4.29e-11 LDL cholesterol levels;LDL cholesterol; CESC cis rs9486719 1.000 rs13210597 chr6:96969694 C/A cg06623918 chr6:96969491 KIAA0776 -0.79 -8.2 -0.45 1.07e-14 Migraine;Coronary artery disease; CESC cis rs7264396 0.635 rs2024854 chr20:34511189 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.61 7.2 0.4 6.24e-12 Total cholesterol levels; CESC cis rs3026445 0.887 rs4766497 chr12:110950376 T/C cg12870014 chr12:110450643 ANKRD13A -0.41 -5.11 -0.3 6.2e-7 QT interval; CESC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg08704250 chr15:31115839 NA 0.64 8.42 0.46 2.39e-15 Huntington's disease progression; CESC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg17252645 chr8:143867129 LY6D -0.3 -5.36 -0.31 1.78e-7 Urinary tract infection frequency; CESC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 8.12 0.45 1.76e-14 Bipolar disorder; CESC cis rs9640161 0.830 rs7800196 chr7:150061534 C/G cg21361702 chr7:150065534 REPIN1 0.49 6.0 0.35 6.61e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs3820068 0.581 rs58567918 chr1:15925823 A/G cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs11252926 0.673 rs816620 chr10:645916 A/G cg16386425 chr10:429943 DIP2C 0.41 5.14 0.3 5.42e-7 Psychosis in Alzheimer's disease; CESC cis rs10838687 0.610 rs4647737 chr11:47253244 T/G cg25783544 chr11:47291846 MADD 0.59 6.84 0.39 5.38e-11 Proinsulin levels; CESC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg12311346 chr5:56204834 C5orf35 -0.71 -8.79 -0.47 1.99e-16 Initial pursuit acceleration; CESC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg04756594 chr16:24857601 SLC5A11 0.45 5.53 0.32 7.79e-8 Intelligence (multi-trait analysis); CESC cis rs727505 1.000 rs10226033 chr7:124521430 C/A cg23710748 chr7:124431027 NA -0.48 -7.53 -0.42 8.1e-13 Lewy body disease; CESC cis rs2477686 0.526 rs2477690 chr1:2395563 G/A cg11214544 chr1:2391121 NA -0.41 -6.28 -0.36 1.34e-9 Non-obstructive azoospermia; CESC cis rs1153858 1.000 rs28679834 chr15:45616206 C/T cg21132104 chr15:45694354 SPATA5L1 0.82 10.82 0.55 7.93e-23 Homoarginine levels; CESC cis rs13256369 0.802 rs12541520 chr8:8564146 G/T cg00074818 chr8:8560427 CLDN23 0.36 5.41 0.32 1.39e-7 Obesity-related traits; CESC cis rs7208859 0.573 rs79505916 chr17:29062326 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.51 0.37 3.66e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17213946 chr1:43997516 PTPRF 0.54 6.17 0.35 2.54e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26371787 chr6:7910221 TXNDC5 0.61 7.41 0.41 1.65e-12 Gut microbiome composition (summer); CESC cis rs920590 0.684 rs3899017 chr8:19669198 A/T cg17834443 chr8:19674713 INTS10 0.59 6.47 0.37 4.61e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs4604732 0.603 rs10925051 chr1:247641834 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.4 5.78 0.33 2.12e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs3008870 0.583 rs3008861 chr1:67396222 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 10.97 0.56 2.49e-23 Lymphocyte percentage of white cells; CESC cis rs694739 1.000 rs646153 chr11:64089588 C/T cg02228329 chr11:64053129 BAD;GPR137 0.72 9.21 0.49 1.06e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg05347473 chr6:146136440 FBXO30 0.55 7.07 0.4 1.34e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs17854409 0.536 rs3765464 chr20:61485236 T/C cg07645718 chr20:61493192 TCFL5 0.83 5.99 0.35 6.94e-9 Obesity-related traits; CESC cis rs4642101 0.737 rs4299468 chr3:12825559 G/A cg24848339 chr3:12840334 CAND2 0.38 5.94 0.34 8.89e-9 QRS complex (12-leadsum); CESC cis rs7116495 0.881 rs598835 chr11:71797727 C/T cg26138937 chr11:71823887 C11orf51 -0.86 -7.03 -0.4 1.75e-11 Severe influenza A (H1N1) infection; CESC cis rs8062405 0.965 rs62037363 chr16:28865042 T/C cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1023500 0.506 rs6002625 chr22:42517689 A/G cg15557168 chr22:42548783 NA 0.4 5.34 0.31 1.96e-7 Schizophrenia; CESC cis rs62244186 0.566 rs6766221 chr3:44882784 C/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.43 5.58 0.32 5.99e-8 Depressive symptoms; CESC cis rs10911232 0.507 rs28477876 chr1:183019882 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 13.5 0.64 6.03e-32 Hypertriglyceridemia; CESC cis rs2742234 0.541 rs1317214 chr10:43733531 C/G cg15436174 chr10:43711423 RASGEF1A 0.47 5.52 0.32 7.96e-8 Hirschsprung disease; CESC cis rs2243480 1.000 rs1499613 chr7:65730860 G/A cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs55883249 0.958 rs17362734 chr2:9730208 A/G cg23886495 chr2:9695866 ADAM17 0.6 5.6 0.33 5.39e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs7246657 0.943 rs7255407 chr19:37933936 G/A cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.69e-9 Coronary artery calcification; CESC cis rs7520050 0.966 rs6656992 chr1:46333068 C/G cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.4e-7 Red blood cell count;Reticulocyte count; CESC cis rs3762637 1.000 rs10049131 chr3:122202102 A/T cg24169773 chr3:122142474 KPNA1 -0.54 -6.29 -0.36 1.28e-9 LDL cholesterol levels; CESC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.53 0.51 1.03e-18 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20367329 chr17:17399941 RASD1 0.57 6.06 0.35 4.55e-9 Gut microbiome composition (summer); CESC trans rs4942242 0.574 rs9533557 chr13:44197487 C/G cg19169023 chr15:41853346 TYRO3 0.58 7.2 0.4 6.27e-12 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3815700 1.000 rs8109990 chr19:33095636 A/G cg24916020 chr19:33096688 ANKRD27 0.59 5.72 0.33 2.85e-8 Eosinophilic esophagitis; CESC cis rs706334 0.905 rs706333 chr4:140517700 A/G cg22540532 chr4:140518177 NA -0.4 -6.35 -0.36 9.21e-10 LDL peak particle diameter (total fat intake interaction); CESC cis rs7980687 0.527 rs1626703 chr12:123710835 A/C cg05973401 chr12:123451056 ABCB9 0.57 7.12 0.4 1.03e-11 Height;Educational attainment;Head circumference (infant); CESC cis rs13256369 0.950 rs13255655 chr8:8577736 C/T cg17143192 chr8:8559678 CLDN23 0.7 7.69 0.43 2.98e-13 Obesity-related traits; CESC cis rs1976403 0.659 rs10799701 chr1:21820990 A/G cg04349561 chr1:21808255 NBPF3 -0.38 -5.49 -0.32 9.63e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs12220238 1.000 rs10824090 chr10:75923446 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.63 6.43 0.37 5.9e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2479724 0.901 rs33954419 chr6:41786136 A/G cg08135965 chr6:41755394 TOMM6 0.41 5.49 0.32 9.53e-8 Menarche (age at onset); CESC cis rs7555523 0.887 rs4657476 chr1:165732661 A/G cg24409356 chr1:165738333 TMCO1 -0.92 -8.51 -0.46 1.29e-15 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs8060686 0.641 rs7193935 chr16:68071147 C/T cg26727032 chr16:67993705 SLC12A4 -0.52 -6.44 -0.37 5.46e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs10129255 0.500 rs4774008 chr14:107137290 A/T cg07470598 chr14:107239068 NA 0.37 5.22 0.31 3.68e-7 Kawasaki disease; CESC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg21248554 chr2:27665150 KRTCAP3 -0.34 -6.98 -0.39 2.34e-11 Total body bone mineral density; CESC cis rs7301826 0.651 rs10773825 chr12:131298913 G/A cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg10691866 chr7:65817282 TPST1 0.31 5.34 0.31 2.05e-7 Aortic root size; CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg09177884 chr7:1199841 ZFAND2A -0.59 -6.55 -0.37 2.92e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10463316 0.894 rs11167542 chr5:150760282 A/G cg03212797 chr5:150827313 SLC36A1 0.44 5.67 0.33 3.78e-8 Metabolite levels (Pyroglutamine); CESC cis rs962856 0.619 rs6739471 chr2:67585593 T/C cg09028215 chr2:67624308 ETAA1 -0.44 -5.34 -0.31 1.97e-7 Pancreatic cancer; CESC trans rs116095464 0.558 rs6555058 chr5:226376 C/T cg00938859 chr5:1591904 SDHAP3 -0.59 -6.38 -0.36 7.76e-10 Breast cancer; CESC cis rs637571 0.524 rs674363 chr11:65699134 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.46 -6.55 -0.37 2.93e-10 Eosinophil percentage of white cells; CESC cis rs9543976 1.000 rs2296146 chr13:76143572 T/C cg01531495 chr13:76123901 UCHL3 -0.55 -5.45 -0.32 1.14e-7 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04579203 chr1:87597566 LOC339524 0.61 7.27 0.41 4.08e-12 Gut microbiome composition (summer); CESC cis rs11264213 0.901 rs584873 chr1:36431806 C/A cg27506609 chr1:36549197 TEKT2 0.67 5.61 0.33 5.12e-8 Schizophrenia; CESC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC cis rs7772486 0.875 rs9399572 chr6:146362945 T/G cg05347473 chr6:146136440 FBXO30 0.47 6.16 0.35 2.66e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs854765 0.565 rs4072738 chr17:17884547 A/C cg04398451 chr17:18023971 MYO15A -0.6 -8.63 -0.47 5.68e-16 Total body bone mineral density; CESC cis rs9902453 0.967 rs28792710 chr17:28450015 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.6 0.42 5.23e-13 Coffee consumption (cups per day); CESC cis rs910316 1.000 rs12588240 chr14:75612083 C/A cg16144293 chr14:75469539 EIF2B2 -0.39 -5.07 -0.3 7.52e-7 Height; CESC cis rs6690583 0.623 rs12042160 chr1:85504516 A/G cg22153463 chr1:85462885 MCOLN2 0.79 7.58 0.42 5.8e-13 Serum sulfate level; CESC cis rs13191362 0.507 rs2849524 chr6:163127070 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -6.67 -0.38 1.47e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1847202 0.859 rs13068268 chr3:72938132 G/A cg25664220 chr3:72788482 NA -0.42 -6.2 -0.36 2.1e-9 Motion sickness; CESC cis rs910316 0.967 rs175479 chr14:75561871 A/C cg11812906 chr14:75593930 NEK9 -0.88 -15.04 -0.68 2.26e-37 Height; CESC cis rs3749237 0.964 rs2352967 chr3:49871641 C/T cg03060546 chr3:49711283 APEH 0.65 7.65 0.43 3.83e-13 Resting heart rate; CESC cis rs17761864 0.675 rs72815344 chr17:2046947 T/C cg16513277 chr17:2031491 SMG6 0.41 5.18 0.3 4.35e-7 Esophageal cancer (squamous cell); CESC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg11859384 chr17:80120422 CCDC57 0.38 5.22 0.31 3.67e-7 Life satisfaction; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02306946 chr12:105630036 APPL2 -0.43 -6.3 -0.36 1.26e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs992157 0.835 rs34353396 chr2:219153982 T/C cg00012203 chr2:219082015 ARPC2 -0.75 -9.65 -0.51 4.46e-19 Colorectal cancer; CESC trans rs1814175 0.626 rs1722008 chr11:49897676 A/T cg03929089 chr4:120376271 NA -0.91 -15.01 -0.68 2.72e-37 Height; CESC cis rs6964587 1.000 rs10488510 chr7:91660225 G/T cg17063962 chr7:91808500 NA 0.56 7.69 0.43 2.93e-13 Breast cancer; CESC cis rs7635838 0.785 rs2606735 chr3:11400714 A/C cg00170343 chr3:11313890 ATG7 0.46 6.42 0.37 6.35e-10 HDL cholesterol; CESC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg11764359 chr7:65958608 NA 0.73 10.6 0.55 4.14e-22 Aortic root size; CESC cis rs826838 1.000 rs4575342 chr12:38663831 G/A cg26384229 chr12:38710491 ALG10B 0.82 14.26 0.66 1.22e-34 Heart rate; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16139199 chr18:19180362 ESCO1 0.49 6.86 0.39 4.84e-11 Gut microbiota (bacterial taxa); CESC cis rs9633740 1.000 rs7900536 chr10:82253701 G/T cg00277334 chr10:82204260 NA -0.58 -6.0 -0.35 6.44e-9 Post bronchodilator FEV1; CESC cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg08564027 chr20:61660810 NA 0.91 15.41 0.69 1.11e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg08917208 chr2:24149416 ATAD2B 0.61 5.85 0.34 1.43e-8 Lymphocyte counts; CESC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg22535103 chr8:58192502 C8orf71 -0.93 -10.39 -0.54 1.89e-21 Developmental language disorder (linguistic errors); CESC cis rs6032067 0.777 rs2868236 chr20:43794070 G/A cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs2072732 0.861 rs41334845 chr1:2950370 A/C cg15211996 chr1:2936768 ACTRT2 -0.37 -5.5 -0.32 9.04e-8 Plateletcrit; CESC cis rs1707322 0.721 rs11211165 chr1:46157906 C/T cg03146154 chr1:46216737 IPP 0.82 11.58 0.58 2.25e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg02269571 chr22:50332266 NA -0.56 -6.92 -0.39 3.35e-11 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20272604 chr1:231004631 C1orf198 -0.44 -6.0 -0.35 6.5e-9 Fibrinogen levels; CESC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg24060327 chr5:131705240 SLC22A5 0.76 10.64 0.55 2.96e-22 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00850453 chr7:12726919 ARL4A 0.55 6.7 0.38 1.26e-10 Gut microbiome composition (summer); CESC cis rs8114671 0.562 rs6088646 chr20:33505937 T/C cg24642439 chr20:33292090 TP53INP2 0.44 5.32 0.31 2.18e-7 Height; CESC cis rs11864453 0.713 rs8051882 chr16:72142072 A/G cg16558253 chr16:72132732 DHX38 0.54 8.28 0.45 6.06e-15 Fibrinogen levels; CESC cis rs7301826 0.627 rs1077317 chr12:131314977 C/T cg11011512 chr12:131303247 STX2 0.46 5.74 0.33 2.6e-8 Plasma plasminogen activator levels; CESC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.49 0.37 4.1e-10 Bipolar disorder; CESC cis rs9443189 0.615 rs602873 chr6:76323818 T/A cg01950844 chr6:76311363 SENP6 0.88 9.44 0.5 2.07e-18 Prostate cancer; CESC cis rs2985684 0.895 rs4900940 chr14:50075310 A/C cg02151108 chr14:50098012 C14orf104 -0.41 -5.32 -0.31 2.17e-7 Carotid intima media thickness; CESC cis rs28489187 0.706 rs233119 chr1:85788052 T/C cg16011679 chr1:85725395 C1orf52 0.48 5.65 0.33 4.1e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09432136 chr19:1818466 REXO1 0.49 6.68 0.38 1.38e-10 Fibrinogen levels; CESC cis rs1538970 0.962 rs7532762 chr1:45864695 C/A cg05343316 chr1:45956843 TESK2 0.8 11.55 0.58 2.96e-25 Platelet count; CESC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.78 0.38 7.61e-11 Platelet count; CESC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg04166393 chr7:2884313 GNA12 0.4 5.13 0.3 5.7e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs7116495 0.609 rs11235444 chr11:71831859 G/A cg26138937 chr11:71823887 C11orf51 1.35 8.43 0.46 2.23e-15 Severe influenza A (H1N1) infection; CESC cis rs899997 1.000 rs7182567 chr15:79045054 A/G cg04896959 chr15:78267971 NA 0.4 5.91 0.34 1.04e-8 Coronary artery disease or large artery stroke; CESC cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3768617 1.000 rs1360704 chr1:183099380 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.65 -8.92 -0.48 7.7e-17 Fuchs's corneal dystrophy; CESC trans rs7001362 0.935 rs13251567 chr8:140227205 C/T cg18714679 chr5:40835242 RPL37 0.42 6.0 0.35 6.61e-9 Anti-saccade response; CESC cis rs561341 1.000 rs8069199 chr17:30281845 A/G cg12193833 chr17:30244370 NA -0.59 -6.02 -0.35 5.78e-9 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.18 0.53 9.01e-21 Prudent dietary pattern; CESC cis rs3087591 1.000 rs2107360 chr17:29697901 C/A cg24425628 chr17:29625626 OMG;NF1 -0.45 -5.75 -0.33 2.5e-8 Hip circumference; CESC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg13393036 chr8:95962371 TP53INP1 -0.53 -11.65 -0.58 1.3e-25 Type 2 diabetes; CESC cis rs7523050 0.643 rs67091034 chr1:109402567 C/G cg08274380 chr1:109419600 GPSM2 0.86 5.69 0.33 3.36e-8 Fat distribution (HIV); CESC trans rs4335177 0.716 rs10978568 chr9:109391579 G/A cg16874583 chr12:7781004 NA -0.48 -6.29 -0.36 1.3e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs909674 0.818 rs8136980 chr22:39844574 G/A cg05872129 chr22:39784769 NA -0.8 -10.42 -0.54 1.58e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg04287289 chr16:89883240 FANCA -0.92 -16.21 -0.71 1.64e-41 Vitiligo; CESC cis rs593982 0.920 rs1151500 chr11:65481166 T/C cg08755490 chr11:65554678 OVOL1 1.11 10.27 0.53 4.82e-21 Atopic dermatitis; CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg22907277 chr7:1156413 C7orf50 0.42 5.92 0.34 9.94e-9 Longevity;Endometriosis; CESC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg18350739 chr11:68623251 NA -0.46 -7.02 -0.4 1.88e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg08027265 chr7:2291960 NA 0.45 6.85 0.39 5.06e-11 Bipolar disorder and schizophrenia; CESC trans rs7618501 0.633 rs35065728 chr3:50009176 T/C cg21659725 chr3:3221576 CRBN 0.48 6.65 0.38 1.64e-10 Intelligence (multi-trait analysis); CESC cis rs4849845 0.653 rs3933618 chr2:121035552 T/G cg24070213 chr2:121070622 NA 0.43 6.33 0.36 1.07e-9 Mean platelet volume; CESC cis rs3015497 0.646 rs2934698 chr14:51137883 G/C cg26011998 chr14:51135199 SAV1 -0.58 -6.27 -0.36 1.47e-9 Mean platelet volume; CESC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.66 -8.63 -0.47 5.87e-16 Mean platelet volume; CESC cis rs2228479 0.702 rs11646374 chr16:89857935 G/A cg00800038 chr16:89945340 TCF25 -0.9 -7.51 -0.42 9.25e-13 Skin colour saturation; CESC cis rs6594499 0.872 rs7723819 chr5:110427347 A/G cg04022379 chr5:110408740 TSLP -0.32 -5.76 -0.33 2.28e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs2486288 0.656 rs8041702 chr15:45547093 C/T cg21132104 chr15:45694354 SPATA5L1 -0.58 -6.86 -0.39 4.94e-11 Glomerular filtration rate; CESC cis rs7937682 0.632 rs7128862 chr11:111755435 C/T cg09085632 chr11:111637200 PPP2R1B 0.87 10.93 0.56 3.49e-23 Primary sclerosing cholangitis; CESC cis rs9581857 0.725 rs9319366 chr13:28017722 C/T cg01674679 chr13:27998804 GTF3A -0.68 -5.41 -0.32 1.42e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs28647808 1.000 rs2285482 chr9:136271792 G/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs17253792 0.822 rs10148122 chr14:56146694 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.78 5.66 0.33 4e-8 Putamen volume; CESC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg02564969 chr6:151773285 C6orf211;RMND1 0.61 8.46 0.46 1.89e-15 Menarche (age at onset); CESC cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg10556349 chr10:835070 NA 0.47 5.06 0.3 7.68e-7 Eosinophil percentage of granulocytes; CESC cis rs523522 0.962 rs3893104 chr12:120903936 G/A cg12219531 chr12:120966889 COQ5 0.73 9.29 0.5 5.72e-18 High light scatter reticulocyte count; CESC cis rs2289583 0.503 rs113742359 chr15:75261643 A/G cg14664628 chr15:75095509 CSK 0.46 5.5 0.32 8.73e-8 Systemic lupus erythematosus; CESC cis rs6500602 0.627 rs863501 chr16:4588394 G/C cg08645402 chr16:4508243 NA -0.42 -6.36 -0.36 9.03e-10 Schizophrenia; CESC cis rs2249625 1.000 rs2463731 chr6:72920896 C/G cg18830697 chr6:72922368 RIMS1 -0.44 -6.31 -0.36 1.17e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs1364705 0.955 rs1346014 chr8:120224949 G/C cg09273054 chr8:120220131 MAL2 0.59 6.82 0.39 6.02e-11 Hippocampal atrophy; CESC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg05552183 chr6:42928497 GNMT 0.82 13.78 0.65 6.26e-33 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2380220 0.720 rs9398251 chr6:95984709 C/T cg23517279 chr6:96025343 MANEA 0.51 5.43 0.32 1.3e-7 Behavioural disinhibition (generation interaction); CESC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg19163074 chr7:65112434 INTS4L2 0.42 5.28 0.31 2.63e-7 Aortic root size; CESC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg04315214 chr1:2043799 PRKCZ 0.47 7.73 0.43 2.24e-13 Height; CESC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg18032046 chr6:28092343 ZSCAN16 -0.6 -6.84 -0.39 5.51e-11 Depression; CESC cis rs26868 0.766 rs26867 chr16:2249410 T/C cg02248941 chr16:2239361 CASKIN1 0.39 6.2 0.36 2.19e-9 Height; CESC cis rs1865721 0.656 rs727894 chr18:73137117 C/T cg26385618 chr18:73139727 C18orf62 -0.46 -7.56 -0.42 6.49e-13 Intelligence; CESC cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg22467129 chr15:76604101 ETFA -0.38 -5.81 -0.34 1.81e-8 Blood metabolite levels; CESC cis rs684232 0.602 rs4968057 chr17:517521 T/A cg12384639 chr17:618140 VPS53 0.43 5.51 0.32 8.37e-8 Prostate cancer; CESC cis rs909002 0.830 rs7542583 chr1:32110813 A/G cg13919466 chr1:32135498 COL16A1 -0.46 -8.3 -0.45 5.27e-15 Intelligence (multi-trait analysis); CESC cis rs3820068 0.734 rs72645830 chr1:15889910 A/G cg17385448 chr1:15911702 AGMAT 0.36 5.55 0.32 6.93e-8 Systolic blood pressure; CESC cis rs4076764 0.801 rs6698738 chr1:163359918 G/A cg24596788 chr1:163392923 NA -0.4 -5.55 -0.32 6.85e-8 Motion sickness; CESC cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg06627628 chr2:24431161 ITSN2 -0.67 -6.33 -0.36 1.06e-9 Lymphocyte counts; CESC cis rs116095464 0.558 rs1971229 chr5:268187 A/G cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.51e-10 Breast cancer; CESC cis rs1707322 0.721 rs10789468 chr1:46124558 A/G cg06784218 chr1:46089804 CCDC17 0.4 7.21 0.4 6.01e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1707322 0.758 rs10789474 chr1:46250040 G/T cg03146154 chr1:46216737 IPP 0.81 11.3 0.57 1.99e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs763014 0.931 rs2071980 chr16:626346 A/C cg00908189 chr16:619842 PIGQ 0.67 9.31 0.5 5.02e-18 Height; CESC cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg03806693 chr22:41940476 POLR3H -1.24 -17.21 -0.73 4.56e-45 Vitiligo; CESC cis rs8062405 0.723 rs4788079 chr16:28559363 C/A cg07382826 chr16:28625726 SULT1A1 0.41 6.72 0.38 1.11e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.6 0.42 5.01e-13 Tonsillectomy; CESC cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs921968 0.541 rs599973 chr2:219387273 C/G cg02176678 chr2:219576539 TTLL4 0.5 9.08 0.49 2.49e-17 Mean corpuscular hemoglobin concentration; CESC cis rs12130219 1.000 rs12733173 chr1:152173972 C/T cg17718321 chr1:152188247 HRNR 0.41 5.4 0.32 1.46e-7 Inflammatory skin disease; CESC cis rs6032067 1.000 rs6032069 chr20:43867388 C/T cg10761708 chr20:43804764 PI3 -0.54 -6.69 -0.38 1.33e-10 Blood protein levels; CESC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg12667521 chr19:29218732 NA 0.39 5.52 0.32 8.1e-8 Methadone dose in opioid dependence; CESC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg18904891 chr8:8559673 CLDN23 0.7 8.04 0.44 3.06e-14 Obesity-related traits; CESC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg12756686 chr19:29218302 NA 0.52 6.9 0.39 3.92e-11 Methadone dose in opioid dependence; CESC cis rs7605827 0.930 rs2052437 chr2:15697819 A/G cg19274914 chr2:15703543 NA 0.3 5.45 0.32 1.18e-7 Educational attainment (years of education); CESC cis rs9291683 0.530 rs10939620 chr4:9946132 C/T cg02734326 chr4:10020555 SLC2A9 -0.44 -6.45 -0.37 5.25e-10 Bone mineral density; CESC cis rs66731853 0.557 rs576968 chr1:20901246 A/G cg04087271 chr1:20915334 CDA -0.38 -5.43 -0.32 1.26e-7 Mean corpuscular volume; CESC cis rs7953249 0.807 rs2393791 chr12:121423956 A/G cg02403541 chr12:121454288 C12orf43 0.5 6.92 0.39 3.4e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs4790333 0.562 rs2447104 chr17:2257532 C/T cg02569219 chr17:2266849 SGSM2 0.38 5.09 0.3 6.96e-7 Proinsulin levels; CESC cis rs2243480 1.000 rs36033484 chr7:65390558 T/G cg12463550 chr7:65579703 CRCP 0.71 5.5 0.32 8.79e-8 Diabetic kidney disease; CESC cis rs9291683 0.546 rs4575994 chr4:9997979 G/A cg00071950 chr4:10020882 SLC2A9 0.78 12.58 0.61 8.94e-29 Bone mineral density; CESC cis rs965469 0.901 rs6037586 chr20:3368114 G/A cg25506879 chr20:3388711 C20orf194 -0.58 -6.14 -0.35 2.93e-9 IFN-related cytopenia; CESC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.84 9.06 0.49 2.98e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3106136 0.527 rs2664872 chr4:95146952 G/A cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Capecitabine sensitivity; CESC cis rs9905704 0.918 rs2567901 chr17:56783255 C/T cg12560992 chr17:57184187 TRIM37 0.59 7.06 0.4 1.45e-11 Testicular germ cell tumor; CESC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg27170947 chr2:26402098 FAM59B -0.84 -10.03 -0.52 2.88e-20 Gut microbiome composition (summer); CESC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg04025307 chr7:1156635 C7orf50 0.44 5.17 0.3 4.55e-7 Bronchopulmonary dysplasia; CESC cis rs55788414 0.932 rs34444956 chr16:81185412 C/T cg06400318 chr16:81190750 PKD1L2 -0.6 -6.82 -0.39 6.19e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC cis rs6674176 0.597 rs4031031 chr1:44393533 C/T cg23954153 chr1:44402353 ARTN -0.37 -5.96 -0.34 8.23e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9309473 1.000 rs56672945 chr2:73622663 C/T cg20560298 chr2:73613845 ALMS1 -0.49 -6.49 -0.37 4.28e-10 Metabolite levels; CESC cis rs73058052 0.597 rs11878568 chr19:50095961 T/C cg09250473 chr19:50168907 IRF3;BCL2L12 0.5 5.64 0.33 4.47e-8 Fibrinogen levels; CESC cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs4689592 0.546 rs2359012 chr4:7066053 A/C cg07817883 chr1:32538562 TMEM39B -0.53 -6.12 -0.35 3.37e-9 Monocyte percentage of white cells; CESC cis rs7605827 0.930 rs7577436 chr2:15528281 C/T cg19274914 chr2:15703543 NA 0.3 5.2 0.3 3.99e-7 Educational attainment (years of education); CESC cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg18904891 chr8:8559673 CLDN23 0.71 8.07 0.44 2.44e-14 Obesity-related traits; CESC cis rs4595586 0.545 rs11615700 chr12:39365104 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.57 0.42 6.23e-13 Morning vs. evening chronotype; CESC cis rs365132 0.875 rs691141 chr5:176323298 A/G cg16309518 chr5:176445507 NA 0.37 5.26 0.31 3.01e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09377915 chr6:56295593 NA 0.43 6.26 0.36 1.58e-9 Fibrinogen levels; CESC cis rs10744422 0.528 rs6489245 chr12:123360151 G/A cg22842854 chr12:123319900 HIP1R -0.67 -5.4 -0.32 1.45e-7 Schizophrenia; CESC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg11168104 chr5:1857477 NA -0.38 -5.78 -0.33 2.09e-8 Cardiovascular disease risk factors; CESC cis rs4594175 0.707 rs4901102 chr14:51746605 C/T cg23942311 chr14:51606299 NA -0.33 -5.28 -0.31 2.63e-7 Cancer; CESC cis rs853679 0.546 rs71537572 chr6:27970715 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.88 6.03 0.35 5.35e-9 Depression; CESC cis rs9733 0.744 rs12126004 chr1:150889877 T/C cg18016565 chr1:150552671 MCL1 -0.37 -5.79 -0.34 1.95e-8 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15087571 chr7:5462185 TNRC18 0.55 6.39 0.37 7.48e-10 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg03609598 chr5:56110824 MAP3K1 -0.49 -5.28 -0.31 2.69e-7 Initial pursuit acceleration; CESC cis rs16854884 0.606 rs60676654 chr3:143734937 A/G cg06585982 chr3:143692056 C3orf58 0.5 6.56 0.37 2.84e-10 Economic and political preferences (feminism/equality); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15487600 chr1:155113158 DPM3 -0.45 -6.15 -0.35 2.78e-9 Fibrinogen levels; CESC cis rs698833 0.892 rs1067371 chr2:44651982 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.87 0.34 1.3e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs4268898 0.931 rs55642516 chr2:24502305 A/G cg08917208 chr2:24149416 ATAD2B 0.46 5.32 0.31 2.2e-7 Asthma; CESC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg04166393 chr7:2884313 GNA12 0.58 7.5 0.42 9.48e-13 Height; CESC trans rs6828577 0.779 rs419292 chr4:119634130 T/C cg05098011 chr1:151736092 OAZ3;MRPL9 0.48 6.02 0.35 5.93e-9 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.71 10.42 0.54 1.61e-21 Menarche (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23063716 chr15:75743999 SIN3A -0.44 -6.39 -0.37 7.6e-10 Fibrinogen levels; CESC cis rs1182196 0.502 rs757786 chr7:2836019 C/T cg19717773 chr7:2847554 GNA12 -0.67 -11.54 -0.58 3.05e-25 Plateletcrit; CESC cis rs2274273 0.662 rs67215571 chr14:55673723 G/A cg04306507 chr14:55594613 LGALS3 0.31 5.24 0.31 3.34e-7 Protein biomarker; CESC cis rs863345 0.604 rs2317969 chr1:158491753 A/G cg12129480 chr1:158549410 OR10X1 -0.35 -6.92 -0.39 3.36e-11 Pneumococcal bacteremia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12617538 chr9:69786570 NA -0.52 -6.13 -0.35 3.13e-9 Gut microbiome composition (summer); CESC cis rs2404602 0.647 rs11072612 chr15:76960984 A/T cg00316803 chr15:76480434 C15orf27 0.37 5.36 0.31 1.77e-7 Blood metabolite levels; CESC cis rs17826219 0.500 rs9891256 chr17:29072692 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Body mass index; CESC cis rs11077998 0.967 rs4614761 chr17:80505809 C/T cg10255544 chr17:80519551 FOXK2 0.53 8.37 0.46 3.31e-15 Reticulocyte fraction of red cells; CESC cis rs11098499 0.866 rs12499602 chr4:120284387 T/A cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs12220238 0.908 rs10824124 chr10:75997360 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.22 0.36 1.89e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs1878931 0.507 rs11648783 chr16:3406626 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.69 8.64 0.47 5.55e-16 Body mass index (adult); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25506288 chr19:49217868 MAMSTR -0.45 -6.49 -0.37 4.15e-10 Gambling; CESC trans rs11098499 0.908 rs71614449 chr4:120387055 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.93 0.52 5.63e-20 Corneal astigmatism; CESC cis rs3857536 0.813 rs7766786 chr6:66932889 C/A cg07460842 chr6:66804631 NA -0.42 -5.36 -0.31 1.8e-7 Blood trace element (Cu levels); CESC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.67 0.33 3.73e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs7923609 0.905 rs7088799 chr10:65016174 T/G cg01631684 chr10:65280961 REEP3 -0.45 -5.64 -0.33 4.38e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs2952156 0.684 rs11658786 chr17:37815899 G/A cg00129232 chr17:37814104 STARD3 -0.81 -12.35 -0.6 5.41e-28 Asthma; CESC cis rs501120 1.000 rs534079 chr10:44752558 G/T cg09554077 chr10:44749378 NA 0.52 6.89 0.39 3.96e-11 Coronary artery disease;Coronary heart disease; CESC trans rs17685 0.753 rs4728586 chr7:75802869 T/C cg19862616 chr7:65841803 NCRNA00174 0.84 12.03 0.59 6.77e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs8020095 0.571 rs9323493 chr14:67546180 C/T cg19548862 chr14:67692701 FAM71D -0.51 -6.26 -0.36 1.57e-9 Depression (quantitative trait); CESC cis rs7659604 0.521 rs4833235 chr4:122695136 C/A cg19748678 chr4:122722346 EXOSC9 -0.45 -5.77 -0.33 2.17e-8 Type 2 diabetes; CESC cis rs6547741 1.000 rs6547734 chr2:27830990 G/T cg27432699 chr2:27873401 GPN1 0.49 6.94 0.39 3.02e-11 Oral cavity cancer; CESC cis rs7819412 0.539 rs11250131 chr8:11251175 C/T cg21775007 chr8:11205619 TDH -0.48 -7.24 -0.41 4.72e-12 Triglycerides; CESC cis rs9908102 0.740 rs73298504 chr17:12904102 C/T cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03935544 chr7:42951740 C7orf25 0.58 6.46 0.37 4.99e-10 Gut microbiome composition (summer); CESC cis rs5017598 1.000 rs5017598 chr6:169211494 A/G cg05672967 chr6:169256475 NA 0.38 5.78 0.33 2.13e-8 Pediatric bone mineral density (femoral neck);Pediatric bone mineral density (hip); CESC cis rs11250464 0.833 rs11250466 chr10:1409378 C/T cg26394196 chr10:1453818 ADARB2 -0.41 -5.55 -0.32 6.86e-8 Radiation response; CESC cis rs763014 0.931 rs56048717 chr16:634867 A/G cg00802000 chr16:706648 WDR90 -0.4 -6.08 -0.35 4.11e-9 Height; CESC cis rs9818758 0.607 rs9850917 chr3:49286983 A/G cg00383909 chr3:49044727 WDR6 0.79 6.09 0.35 4e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs7605378 1.000 rs7577763 chr2:200681753 C/T cg23649088 chr2:200775458 C2orf69 0.52 6.74 0.38 9.73e-11 Osteoporosis; CESC cis rs8141529 0.764 rs8137969 chr22:29228484 G/C cg15103426 chr22:29168792 CCDC117 0.68 9.65 0.51 4.52e-19 Lymphocyte counts; CESC cis rs6502050 0.799 rs58538819 chr17:80107153 G/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.38 -0.36 7.89e-10 Life satisfaction; CESC cis rs7219021 0.705 rs1962412 chr17:46970259 T/C cg16584676 chr17:46985605 UBE2Z 0.61 7.58 0.42 5.82e-13 Schizophrenia or bipolar disorder; CESC cis rs67460515 0.563 rs11922959 chr3:160828871 A/G cg03342759 chr3:160939853 NMD3 -0.54 -6.87 -0.39 4.65e-11 Parkinson's disease; CESC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Depression; CESC cis rs7762018 0.891 rs7740218 chr6:170141552 G/A cg05834625 chr6:170176447 C6orf70 0.64 7.17 0.4 7.47e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs7408868 1.000 rs2074622 chr19:15277620 G/C cg14696996 chr19:15285081 NOTCH3 1.11 11.94 0.59 1.43e-26 Pulse pressure; CESC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7296418 0.885 rs1727305 chr12:123633382 T/C cg00376283 chr12:123451042 ABCB9 0.68 9.62 0.51 5.43e-19 Platelet count; CESC cis rs17376456 0.569 rs17083377 chr5:93164870 C/G cg25358565 chr5:93447407 FAM172A 0.63 6.82 0.39 6.31e-11 Diabetic retinopathy; CESC trans rs1945213 0.694 rs9888298 chr11:55865704 T/C cg15704280 chr7:45808275 SEPT13 0.75 7.28 0.41 3.87e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs2204008 0.837 rs11168387 chr12:37962818 G/A cg26384229 chr12:38710491 ALG10B -0.55 -7.78 -0.43 1.6e-13 Bladder cancer; CESC cis rs6963495 0.818 rs118134111 chr7:105161229 A/C cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs858239 0.539 rs4504540 chr7:23186198 C/G cg23682824 chr7:23144976 KLHL7 0.5 6.56 0.37 2.77e-10 Cerebrospinal fluid biomarker levels; CESC cis rs72945132 0.882 rs7941933 chr11:70123351 G/A cg14191688 chr11:70257035 CTTN 0.42 5.12 0.3 5.84e-7 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23677363 chr1:111682944 DRAM2;CEPT1 -0.44 -6.39 -0.37 7.32e-10 Gut microbiota (bacterial taxa); CESC cis rs9858542 1.000 rs1131095 chr3:49714225 T/C cg03060546 chr3:49711283 APEH -0.57 -6.81 -0.39 6.44e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2637266 0.905 rs2130796 chr10:78329712 C/G cg18941641 chr10:78392320 NA 0.38 6.86 0.39 4.99e-11 Pulmonary function; CESC cis rs11031096 0.711 rs61899755 chr11:4201317 G/T cg18678763 chr11:4115507 RRM1 -0.39 -5.06 -0.3 7.72e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg10792982 chr14:105748885 BRF1 0.38 5.45 0.32 1.18e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7208859 0.510 rs216402 chr17:28917126 A/T cg14008862 chr17:28927542 LRRC37B2 0.76 5.66 0.33 3.93e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg17366294 chr4:99064904 C4orf37 0.56 7.68 0.43 3.1e-13 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00624375 chr12:110841656 ANAPC7 -0.57 -6.27 -0.36 1.44e-9 Gut microbiome composition (summer); CESC cis rs12824058 0.831 rs7979497 chr12:130804706 C/T cg23887609 chr12:130822674 PIWIL1 0.43 5.3 0.31 2.45e-7 Menopause (age at onset); CESC cis rs8077889 0.956 rs55768269 chr17:41888997 C/T cg26893861 chr17:41843967 DUSP3 0.82 9.6 0.51 6.18e-19 Triglycerides; CESC cis rs17376456 0.877 rs17083460 chr5:93462354 A/G cg21475434 chr5:93447410 FAM172A 0.82 7.56 0.42 6.81e-13 Diabetic retinopathy; CESC cis rs9896933 0.778 rs80112422 chr17:80827719 G/T cg20578329 chr17:80767326 TBCD -0.75 -7.78 -0.43 1.62e-13 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs4595586 0.545 rs2388176 chr12:39372357 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg26314531 chr2:26401878 FAM59B -0.85 -9.04 -0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs11690935 0.632 rs34531723 chr2:172564094 A/C cg13550731 chr2:172543902 DYNC1I2 0.57 8.08 0.44 2.32e-14 Schizophrenia; CESC cis rs10089 1.000 rs10060390 chr5:127452947 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.07 0.53 2.04e-20 Ileal carcinoids; CESC cis rs757081 0.764 rs2051773 chr11:17365209 A/G cg15432903 chr11:17409602 KCNJ11 -0.47 -5.74 -0.33 2.57e-8 Systolic blood pressure; CESC cis rs57506017 0.585 rs6966915 chr7:12265988 C/T cg23422036 chr7:12250390 TMEM106B 0.38 5.08 0.3 7.18e-7 Neuroticism; CESC cis rs9287719 0.967 rs6432118 chr2:10749441 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs7772486 0.875 rs12194437 chr6:146411440 A/G cg05347473 chr6:146136440 FBXO30 0.51 6.68 0.38 1.37e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg13206674 chr6:150067644 NUP43 0.46 6.73 0.38 1.03e-10 Lung cancer; CESC trans rs2727020 0.576 rs1917321 chr11:49377760 A/C cg03929089 chr4:120376271 NA -0.59 -7.46 -0.42 1.23e-12 Coronary artery disease; CESC cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg17366294 chr4:99064904 C4orf37 0.58 8.39 0.46 2.88e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2180341 0.961 rs910720 chr6:127619070 T/C cg24812749 chr6:127587940 RNF146 1.06 15.35 0.69 1.74e-38 Breast cancer; CESC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg00310523 chr12:86230176 RASSF9 0.35 5.51 0.32 8.46e-8 Major depressive disorder; CESC cis rs3768617 0.510 rs6691755 chr1:183099821 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg08821792 chr21:34144507 C21orf49;C21orf66 0.51 6.45 0.37 5.27e-10 Myopia (pathological); CESC cis rs7408868 0.611 rs11669982 chr19:15292366 C/T cg14696996 chr19:15285081 NOTCH3 0.77 8.89 0.48 9.75e-17 Pulse pressure; CESC cis rs9443645 0.901 rs7749916 chr6:79814192 A/G cg05283184 chr6:79620031 NA -0.44 -6.87 -0.39 4.5e-11 Intelligence (multi-trait analysis); CESC cis rs2204008 0.837 rs1589395 chr12:38420405 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.1 0.35 3.7e-9 Bladder cancer; CESC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg25838465 chr1:92012736 NA -0.61 -8.8 -0.48 1.77e-16 Breast cancer; CESC cis rs7223966 1.000 rs1877316 chr17:61766880 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.54 0.37 3.22e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs523522 0.962 rs2233676 chr12:120933607 G/A cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs9399135 0.967 rs1854865 chr6:135360300 C/G cg22676075 chr6:135203613 NA 0.5 7.07 0.4 1.41e-11 Red blood cell count; CESC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg11766577 chr21:47581405 C21orf56 -0.46 -6.13 -0.35 3.16e-9 Testicular germ cell tumor; CESC cis rs9324022 0.929 rs9635298 chr14:101172542 C/T cg18089426 chr14:101175970 NA 0.62 7.07 0.4 1.36e-11 Plateletcrit; CESC cis rs4919087 0.748 rs701813 chr10:98975632 C/T cg25902810 chr10:99078978 FRAT1 -0.45 -5.2 -0.3 3.96e-7 Monocyte count; CESC cis rs9309473 1.000 rs6740223 chr2:73653332 T/C cg20560298 chr2:73613845 ALMS1 -0.46 -6.2 -0.36 2.19e-9 Metabolite levels; CESC cis rs7191439 0.858 rs11076701 chr16:88774525 A/G cg02389323 chr16:88786976 FAM38A 1.0 8.46 0.46 1.77e-15 Plateletcrit; CESC cis rs4955124 0.643 rs17028716 chr3:32041580 C/G cg05935571 chr3:32023257 ZNF860;OSBPL10 -0.79 -6.37 -0.36 8.39e-10 Schizophrenia; CESC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg22963979 chr7:1858916 MAD1L1 -0.39 -5.42 -0.32 1.37e-7 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13379408 chr18:11909052 MPPE1 0.7 8.24 0.45 8.24e-15 Gut microbiome composition (summer); CESC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg08736216 chr1:53307985 ZYG11A 0.42 7.11 0.4 1.06e-11 Monocyte count; CESC cis rs3806843 0.868 rs2531345 chr5:140126781 T/G cg26395211 chr5:140044315 WDR55 0.39 5.09 0.3 6.79e-7 Depressive symptoms (multi-trait analysis); CESC cis rs80282103 0.618 rs57514701 chr10:1146169 G/A cg08668510 chr10:1095578 IDI1 0.77 6.35 0.36 9.51e-10 Glomerular filtration rate (creatinine); CESC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.92 9.01 0.48 4.18e-17 Platelet count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23436918 chr7:16685595 BZW2;ANKMY2 -0.48 -6.21 -0.36 1.99e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7772486 0.875 rs9390371 chr6:146363180 A/G cg23711669 chr6:146136114 FBXO30 0.76 11.14 0.56 6.6e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs6696846 0.936 rs12134724 chr1:205039288 T/C cg00857998 chr1:205179979 DSTYK 0.53 6.56 0.37 2.79e-10 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00346985 chr1:46940516 NA -0.45 -6.15 -0.35 2.87e-9 Gut microbiome composition (summer); CESC cis rs6687430 0.526 rs6688558 chr1:10611403 A/G cg07384165 chr1:10488281 NA -0.44 -5.93 -0.34 9.4e-9 Hand grip strength; CESC cis rs7714584 1.000 rs10061105 chr5:150255185 C/G cg22134413 chr5:150180641 NA 0.51 5.92 0.34 9.88e-9 Crohn's disease; CESC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg14558114 chr2:88469736 THNSL2 0.57 5.43 0.32 1.29e-7 Plasma clusterin levels; CESC cis rs10129255 0.536 rs6576201 chr14:107139713 A/G cg07958169 chr14:107095056 NA 0.45 7.07 0.4 1.38e-11 Kawasaki disease; CESC cis rs12971120 0.947 rs4891559 chr18:72170397 C/T cg26446133 chr18:72167187 CNDP2 -0.76 -11.82 -0.59 3.53e-26 Refractive error; CESC cis rs11785400 0.793 rs13255558 chr8:143748080 C/T cg10596483 chr8:143751796 JRK 0.43 5.35 0.31 1.93e-7 Schizophrenia; CESC cis rs8036030 0.604 rs11856835 chr15:74716174 G/A cg14664628 chr15:75095509 CSK -0.51 -6.23 -0.36 1.81e-9 Airflow obstruction; CESC cis rs11792861 0.926 rs3750451 chr9:111822866 C/T cg05043794 chr9:111880884 C9orf5 -0.39 -6.39 -0.37 7.26e-10 Menarche (age at onset); CESC trans rs4921164 1.000 rs11950065 chr5:158543969 A/G cg27516404 chr7:155640019 NA 0.39 6.18 0.35 2.44e-9 Gut microbiome composition (winter); CESC cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg05283184 chr6:79620031 NA -0.43 -6.72 -0.38 1.1e-10 Intelligence (multi-trait analysis); CESC cis rs7551222 0.752 rs12125533 chr1:204529302 A/C cg20240347 chr1:204465584 NA -0.28 -5.71 -0.33 2.96e-8 Schizophrenia; CESC cis rs644799 1.000 rs473155 chr11:95596873 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.88 12.6 0.61 7.79e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7191700 0.836 rs12708722 chr16:11428905 T/A cg00044050 chr16:11439710 C16orf75 0.49 5.65 0.33 4.03e-8 Multiple sclerosis; CESC cis rs2576037 0.796 rs2576043 chr18:44573476 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.45 5.79 0.34 1.95e-8 Personality dimensions; CESC cis rs2204008 0.684 rs11514164 chr12:38036494 C/T cg26384229 chr12:38710491 ALG10B 0.66 9.39 0.5 2.96e-18 Bladder cancer; CESC cis rs17401966 1.000 rs12118323 chr1:10469641 A/G cg15208524 chr1:10270712 KIF1B 0.41 5.16 0.3 4.86e-7 Hepatocellular carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18242990 chr7:2884021 GNA12 0.56 6.38 0.36 7.79e-10 Gut microbiome composition (summer); CESC cis rs3845702 0.736 rs72962575 chr2:180862133 C/G cg01881094 chr2:180872142 CWC22 1.08 9.4 0.5 2.75e-18 Schizophrenia; CESC cis rs561341 1.000 rs483301 chr17:30293398 G/T cg00745463 chr17:30367425 LRRC37B -0.85 -7.72 -0.43 2.36e-13 Hip circumference adjusted for BMI; CESC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg21361702 chr7:150065534 REPIN1 0.57 5.92 0.34 9.9e-9 Blood protein levels;Circulating chemerin levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26220259 chr1:44444688 B4GALT2 -0.52 -6.33 -0.36 1.03e-9 Ulcerative colitis; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg20566420 chr12:122327043 PSMD9 0.46 6.03 0.35 5.5e-9 Weight; CESC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg05332525 chr7:65337924 VKORC1L1 -0.51 -6.24 -0.36 1.75e-9 Aortic root size; CESC trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg15704280 chr7:45808275 SEPT13 0.82 12.23 0.6 1.45e-27 Coronary artery disease; CESC cis rs9910055 0.550 rs113844752 chr17:42297631 C/A cg13607699 chr17:42295918 UBTF 0.86 12.51 0.61 1.53e-28 Total body bone mineral density; CESC cis rs6904897 0.563 rs4896117 chr6:135229400 T/C cg22676075 chr6:135203613 NA -0.66 -9.73 -0.51 2.54e-19 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs9987353 0.518 rs4841110 chr8:9086023 C/T cg06636001 chr8:8085503 FLJ10661 0.56 6.87 0.39 4.49e-11 Recombination measurement; CESC cis rs763121 0.853 rs4821811 chr22:39075145 C/T cg21395723 chr22:39101663 GTPBP1 0.42 5.25 0.31 3.14e-7 Menopause (age at onset); CESC cis rs1691799 0.899 rs1168301 chr12:66736771 C/T cg16791601 chr12:66731901 HELB -0.61 -10.12 -0.53 1.39e-20 White blood cell count (basophil); CESC cis rs1707322 0.963 rs10890371 chr1:46390897 T/G cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs904092 0.720 rs1618572 chr4:100195121 C/G cg12011299 chr4:100065546 ADH4 0.54 6.3 0.36 1.26e-9 Alcohol dependence; CESC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg25985355 chr7:65971099 NA 0.32 5.34 0.31 2e-7 Aortic root size; CESC cis rs1847202 0.859 rs4550778 chr3:72949198 G/A cg10804678 chr3:72788309 NA -0.39 -5.25 -0.31 3.19e-7 Motion sickness; CESC cis rs412000 0.553 rs2680702 chr17:56431549 A/G cg25039879 chr17:56429692 SUPT4H1 0.6 7.59 0.42 5.55e-13 Primary tooth development (time to first tooth eruption); CESC cis rs4919694 1.000 rs58700372 chr10:104800205 T/C cg04362960 chr10:104952993 NT5C2 0.79 7.02 0.4 1.86e-11 Arsenic metabolism; CESC cis rs12477438 0.798 rs1530996 chr2:99584079 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.73 -10.26 -0.53 5.33e-21 Chronic sinus infection; CESC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 9.37 0.5 3.43e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.69 -10.89 -0.56 4.48e-23 Personality dimensions; CESC cis rs2191566 0.887 rs55703004 chr19:44504781 T/G cg20607764 chr19:44506953 ZNF230 -0.56 -7.01 -0.4 1.94e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg06634786 chr22:41940651 POLR3H -0.64 -6.73 -0.38 1.07e-10 Vitiligo; CESC cis rs1062177 0.826 rs2053063 chr5:151166764 T/C cg00977110 chr5:151150581 G3BP1 0.62 6.78 0.38 7.64e-11 Preschool internalizing problems; CESC cis rs2425143 1.000 rs7273815 chr20:34232415 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -7.65 -0.43 3.73e-13 Blood protein levels; CESC cis rs9513593 1.000 rs9585019 chr13:99850487 T/C cg21788972 chr13:99853209 UBAC2 0.64 7.39 0.41 1.97e-12 Psoriasis; CESC cis rs208515 0.556 rs12201658 chr6:66678457 T/C cg07460842 chr6:66804631 NA 0.85 10.63 0.55 3.24e-22 Exhaled nitric oxide levels; CESC cis rs7918232 0.662 rs10741125 chr10:27288925 G/A cg14240646 chr10:27532245 ACBD5 -0.49 -5.28 -0.31 2.7e-7 Breast cancer; CESC cis rs1153858 1.000 rs9788780 chr15:45685487 T/A cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.71e-25 Homoarginine levels; CESC cis rs28830936 0.966 rs62002090 chr15:42092326 C/T cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.44 -5.79 -0.34 1.99e-8 Diastolic blood pressure; CESC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg15445000 chr17:37608096 MED1 0.38 6.07 0.35 4.33e-9 Glomerular filtration rate (creatinine); CESC cis rs66686620 1.000 rs13420940 chr2:69250234 C/T cg12800200 chr2:69260302 ANTXR1 0.41 6.34 0.36 9.66e-10 Breast cancer; CESC cis rs4481887 1.000 rs4244183 chr1:248471222 G/A cg00666640 chr1:248458726 OR2T12 0.39 6.36 0.36 8.71e-10 Common traits (Other); CESC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg06873352 chr17:61820015 STRADA 0.73 12.81 0.62 1.47e-29 Prudent dietary pattern; CESC cis rs7592578 0.771 rs4439990 chr2:191398353 A/C cg10560079 chr2:191398806 TMEM194B -0.66 -5.86 -0.34 1.35e-8 Diastolic blood pressure; CESC cis rs2200578 1.000 rs7566277 chr2:99916242 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.53 5.87 0.34 1.33e-8 IgG glycosylation; CESC cis rs6912958 0.712 rs2246113 chr6:88410050 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.46 -5.8 -0.34 1.9e-8 Monocyte percentage of white cells; CESC cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.28 0.31 2.75e-7 Menopause (age at onset); CESC cis rs9309473 0.554 rs4330127 chr2:73581320 A/T cg20560298 chr2:73613845 ALMS1 -0.45 -6.09 -0.35 3.94e-9 Metabolite levels; CESC cis rs9300255 0.602 rs2695479 chr12:123689386 T/C cg00376283 chr12:123451042 ABCB9 0.61 6.51 0.37 3.83e-10 Neutrophil percentage of white cells; CESC cis rs11098499 0.866 rs13125526 chr4:120288019 G/A cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.42 0.54 1.51e-21 Prudent dietary pattern; CESC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg00908189 chr16:619842 PIGQ 0.64 8.97 0.48 5.42e-17 Height; CESC cis rs9309473 0.500 rs2421582 chr2:73898420 A/G cg20560298 chr2:73613845 ALMS1 0.53 7.35 0.41 2.52e-12 Metabolite levels; CESC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.67 -8.37 -0.46 3.38e-15 Mean platelet volume; CESC cis rs3947 0.950 rs1293331 chr8:11698436 C/T cg00262122 chr8:11665843 FDFT1 -0.5 -5.17 -0.3 4.55e-7 Blood protein levels; CESC cis rs9796 0.621 rs537244 chr15:41469313 G/T cg18705301 chr15:41695430 NDUFAF1 0.44 6.46 0.37 4.86e-10 Menopause (age at onset); CESC cis rs4450798 0.744 rs9653971 chr3:13749727 T/C cg23332027 chr3:13681764 NA 0.4 5.29 0.31 2.58e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs11098499 0.955 rs1511019 chr4:120166007 T/G cg25214090 chr10:38739885 LOC399744 0.63 8.36 0.46 3.49e-15 Corneal astigmatism; CESC cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg27478167 chr7:817139 HEATR2 -0.52 -6.12 -0.35 3.4e-9 Cerebrospinal P-tau181p levels; CESC cis rs2070997 0.607 rs4504690 chr9:133663764 A/G cg11464064 chr9:133710261 ABL1 0.58 6.88 0.39 4.42e-11 Response to amphetamines; CESC cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg26516362 chr5:178986906 RUFY1 -0.36 -5.25 -0.31 3.11e-7 Lung cancer; CESC cis rs10504229 0.679 rs72649131 chr8:58054288 G/T cg24829409 chr8:58192753 C8orf71 -0.51 -6.38 -0.36 7.84e-10 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg03467027 chr4:99064603 C4orf37 0.48 6.04 0.35 5.14e-9 Colonoscopy-negative controls vs population controls; CESC cis rs939574 0.790 rs2276635 chr2:220087441 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.89 6.86 0.39 4.73e-11 Platelet distribution width; CESC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg23131131 chr22:24373011 LOC391322 -0.69 -9.95 -0.52 4.91e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9858542 0.537 rs35869135 chr3:49359102 A/G cg00383909 chr3:49044727 WDR6 0.6 5.49 0.32 9.29e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4332037 0.851 rs10268609 chr7:1962163 A/C cg23422044 chr7:1970798 MAD1L1 -0.52 -5.44 -0.32 1.22e-7 Bipolar disorder; CESC cis rs2228479 0.850 rs11639788 chr16:89807543 G/A cg14709524 chr16:89940631 TCF25 0.91 6.86 0.39 4.91e-11 Skin colour saturation; CESC cis rs4664308 0.618 rs4665138 chr2:160890427 C/T cg03641300 chr2:160917029 PLA2R1 -0.6 -8.8 -0.48 1.82e-16 Idiopathic membranous nephropathy; CESC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.88 10.19 0.53 8.59e-21 Mean platelet volume; CESC cis rs9611565 0.506 rs1984839 chr22:41685937 G/C cg17376030 chr22:41985996 PMM1 0.48 5.39 0.31 1.58e-7 Vitiligo; CESC cis rs1062177 1.000 rs17741826 chr5:151149262 C/T cg12924095 chr5:151150029 G3BP1 -0.49 -6.43 -0.37 5.82e-10 Preschool internalizing problems; CESC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg17971929 chr21:40555470 PSMG1 0.86 12.55 0.61 1.16e-28 Cognitive function; CESC cis rs3026101 0.671 rs56190856 chr17:5297149 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.65 0.33 4.03e-8 Body mass index; CESC cis rs116095464 0.558 rs6555058 chr5:226376 C/T cg22496380 chr5:211416 CCDC127 0.68 7.86 0.43 9.79e-14 Breast cancer; CESC trans rs11148252 0.508 rs6561671 chr13:53182314 G/A cg18335740 chr13:41363409 SLC25A15 0.58 8.17 0.45 1.24e-14 Lewy body disease; CESC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg24562669 chr7:97807699 LMTK2 0.49 7.16 0.4 7.94e-12 Prostate cancer (SNP x SNP interaction); CESC trans rs722599 0.683 rs2058918 chr14:75288518 A/G cg00095594 chr1:236228625 NID1 0.4 6.04 0.35 5.2e-9 IgG glycosylation; CESC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg24101359 chr6:42928495 GNMT 0.57 7.98 0.44 4.31e-14 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2456568 0.900 rs2511399 chr11:93682156 C/T cg26875233 chr11:93583750 C11orf90 0.28 5.04 0.3 8.65e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00962125 chr14:24616485 PSME2;RNF31 -0.47 -6.06 -0.35 4.6e-9 Ulcerative colitis; CESC cis rs8060686 0.641 rs76595854 chr16:68130233 T/C cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 4.92e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs9911578 0.835 rs9788975 chr17:56460800 G/A cg05425664 chr17:57184151 TRIM37 0.41 5.73 0.33 2.76e-8 Intelligence (multi-trait analysis); CESC trans rs561341 1.000 rs537166 chr17:30326827 C/T cg27661571 chr11:113659931 NA -0.7 -7.12 -0.4 1.01e-11 Hip circumference adjusted for BMI; CESC cis rs7131987 0.801 rs962866 chr12:29434147 A/G cg09582351 chr12:29534625 ERGIC2 -0.31 -5.11 -0.3 6.29e-7 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15249164 chr21:35288186 ATP5O 0.58 7.55 0.42 7.09e-13 Gut microbiome composition (summer); CESC cis rs11098499 0.954 rs10006706 chr4:120409152 A/G cg09307838 chr4:120376055 NA 0.92 12.92 0.62 6.07e-30 Corneal astigmatism; CESC trans rs10776614 0.799 rs12358315 chr10:49765392 A/G cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs10425465 0.710 rs62125166 chr19:33884411 T/G cg06856480 chr19:34850338 NA 0.51 5.07 0.3 7.65e-7 Schizophrenia; CESC cis rs2180341 0.781 rs877102 chr6:127587086 T/C cg27446573 chr6:127587934 RNF146 0.84 11.93 0.59 1.5e-26 Breast cancer; CESC cis rs6964587 0.967 rs55801687 chr7:91762629 C/A cg17063962 chr7:91808500 NA 0.59 8.13 0.45 1.69e-14 Breast cancer; CESC cis rs951366 0.677 rs1775140 chr1:205672107 C/A cg11965913 chr1:205819406 PM20D1 0.81 12.49 0.61 1.81e-28 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13797019 chr14:105303134 NA -0.59 -6.88 -0.39 4.2e-11 Gut microbiome composition (summer); CESC cis rs155076 1.000 rs58519241 chr13:21845006 C/A cg11317459 chr13:21872234 NA -1.01 -11.12 -0.56 7.88e-24 White matter hyperintensity burden; CESC cis rs2243480 0.803 rs55700941 chr7:65389800 T/A cg25894440 chr7:65020034 NA -0.64 -5.29 -0.31 2.53e-7 Diabetic kidney disease; CESC cis rs6582630 0.519 rs11495373 chr12:38275470 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.7 0.51 3.2e-19 Drug-induced liver injury (flucloxacillin); CESC cis rs3820928 0.775 rs10179756 chr2:227897076 A/G cg11843606 chr2:227700838 RHBDD1 -0.49 -6.47 -0.37 4.65e-10 Pulmonary function; CESC cis rs7474896 0.583 rs1735621 chr10:38167723 G/T cg25427524 chr10:38739819 LOC399744 0.49 5.52 0.32 8.07e-8 Obesity (extreme); CESC cis rs1153858 0.621 rs1719237 chr15:45579822 G/A cg09092052 chr15:45571596 NA -0.45 -5.11 -0.3 6.26e-7 Homoarginine levels; CESC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.41 5.05 0.3 8.12e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2573652 0.674 rs11630583 chr15:100543355 G/A cg00587665 chr15:100533223 ADAMTS17 -0.41 -6.75 -0.38 9.15e-11 Height; CESC cis rs9322193 0.884 rs7744105 chr6:150170444 A/G cg09699651 chr6:150184138 LRP11 0.5 6.5 0.37 3.89e-10 Lung cancer; CESC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg12373951 chr3:133503437 NA 0.43 6.22 0.36 1.92e-9 Iron status biomarkers; CESC cis rs2952156 0.883 rs12150603 chr17:37834715 G/A cg20243544 chr17:37824526 PNMT 0.63 8.5 0.46 1.38e-15 Asthma; CESC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg02807482 chr3:125708958 NA -0.39 -5.11 -0.3 6.29e-7 Blood pressure (smoking interaction); CESC cis rs2235642 0.787 rs2235646 chr16:1601287 A/G cg08296037 chr16:1584118 IFT140;TMEM204 -0.31 -5.05 -0.3 8.1e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00793990 chr12:132603671 EP400NL -0.59 -7.07 -0.4 1.41e-11 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs2814871 chr6:146312274 G/T cg23711669 chr6:146136114 FBXO30 0.78 11.23 0.57 3.44e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs9443189 0.855 rs1321161 chr6:76454182 G/A cg01950844 chr6:76311363 SENP6 -0.66 -7.06 -0.4 1.48e-11 Prostate cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15606692 chr11:124669480 C11orf61 -0.45 -6.35 -0.36 9.09e-10 Gut microbiota (bacterial taxa); CESC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg00166722 chr3:10149974 C3orf24 -0.43 -5.74 -0.33 2.58e-8 Alzheimer's disease; CESC cis rs7605827 0.930 rs7605077 chr2:15546240 C/A cg19274914 chr2:15703543 NA 0.38 6.79 0.39 7.26e-11 Educational attainment (years of education); CESC cis rs9287719 0.934 rs4371336 chr2:10755723 C/A cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs7833986 0.501 rs2976036 chr8:57031721 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.57 7.28 0.41 3.83e-12 Height; CESC trans rs9325144 0.647 rs870431 chr12:38953073 T/C cg23762105 chr12:34175262 ALG10 0.48 6.45 0.37 5.35e-10 Morning vs. evening chronotype; CESC cis rs929354 1.000 rs1182384 chr7:157040642 A/G cg05182265 chr7:156933206 UBE3C 0.43 5.93 0.34 9.31e-9 Body mass index; CESC cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg12463550 chr7:65579703 CRCP 0.57 7.16 0.4 8.19e-12 Aortic root size; CESC cis rs4662945 0.525 rs28625431 chr2:130303333 A/G cg05962382 chr2:130345044 NA -0.5 -7.68 -0.43 3.16e-13 Response to cytidine analogues (gemcitabine); CESC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg12311346 chr5:56204834 C5orf35 -0.65 -8.84 -0.48 1.32e-16 Initial pursuit acceleration; CESC cis rs367943 0.698 rs2195373 chr5:112998798 G/C cg12552261 chr5:112820674 MCC 0.45 5.77 0.33 2.18e-8 Type 2 diabetes; CESC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg07414643 chr4:187882934 NA 0.54 7.39 0.41 1.87e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs11098499 1.000 rs13116504 chr4:120209412 A/C cg25214090 chr10:38739885 LOC399744 0.67 9.13 0.49 1.78e-17 Corneal astigmatism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01044692 chr2:208490024 FAM119A -0.46 -6.22 -0.36 1.98e-9 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14132868 chr11:18343680 HPS5;GTF2H1 -0.47 -6.54 -0.37 3.19e-10 Fibrinogen levels; CESC cis rs78889164 0.910 rs79824755 chr19:33865323 G/T cg02272751 chr19:33882848 PEPD -0.52 -6.8 -0.39 7.1e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg24846343 chr22:24311635 DDTL 0.65 11.27 0.57 2.55e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9300255 0.596 rs11057202 chr12:123720775 G/T cg19016782 chr12:123741754 C12orf65 -0.36 -5.32 -0.31 2.26e-7 Neutrophil percentage of white cells; CESC cis rs7809950 0.773 rs9791733 chr7:107041730 T/C cg23024343 chr7:107201750 COG5 -0.58 -7.33 -0.41 2.82e-12 Coronary artery disease; CESC cis rs10870270 0.912 rs7079991 chr10:133736130 A/G cg08754478 chr10:133766260 PPP2R2D -0.62 -8.06 -0.44 2.63e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs10744422 1.000 rs897385 chr12:123341297 A/G cg25930673 chr12:123319894 HIP1R -0.85 -6.42 -0.37 6.38e-10 Schizophrenia; CESC cis rs4268898 0.527 rs72789910 chr2:24388609 T/G cg08917208 chr2:24149416 ATAD2B 0.63 5.66 0.33 3.97e-8 Asthma; CESC cis rs9814567 0.806 rs9824185 chr3:134324024 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.38 -5.06 -0.3 7.86e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg02034447 chr16:89574710 SPG7 0.47 6.06 0.35 4.61e-9 Multiple myeloma (IgH translocation); CESC cis rs12410462 0.901 rs16847844 chr1:227638110 A/G cg04117972 chr1:227635322 NA 0.62 6.26 0.36 1.53e-9 Major depressive disorder; CESC cis rs7917772 0.503 rs61871067 chr10:104295382 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.48 5.2 0.3 3.93e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs12748961 0.557 rs823127 chr1:205713139 G/A cg07167872 chr1:205819463 PM20D1 0.39 5.24 0.31 3.23e-7 White blood cell types; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01356910 chr16:4323571 TFAP4 -0.53 -6.68 -0.38 1.41e-10 Ulcerative colitis; CESC cis rs4654899 0.965 rs6692244 chr1:21396886 C/A cg05370193 chr1:21551575 ECE1 0.39 5.91 0.34 1.06e-8 Superior frontal gyrus grey matter volume; CESC cis rs9911578 0.935 rs9893351 chr17:57023326 G/A cg05425664 chr17:57184151 TRIM37 -0.4 -5.52 -0.32 8.26e-8 Intelligence (multi-trait analysis); CESC cis rs2721195 0.874 rs2721173 chr8:145744429 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 0.74 11.18 0.57 5.03e-24 Age at first birth; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg18564448 chr14:77564276 KIAA1737 -0.49 -6.4 -0.37 7.19e-10 Recombination measurement; CESC cis rs7084402 0.967 rs1820542 chr10:60315643 T/C cg07615347 chr10:60278583 BICC1 0.59 8.89 0.48 9.83e-17 Refractive error; CESC cis rs17023223 0.553 rs56234947 chr1:119707744 G/A cg05756136 chr1:119680316 WARS2 -0.48 -5.78 -0.33 2.05e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs8180040 0.966 rs11130129 chr3:47489885 G/C cg27129171 chr3:47204927 SETD2 -0.63 -9.47 -0.5 1.6e-18 Colorectal cancer; CESC cis rs1669338 0.588 rs3931974 chr3:3186894 A/G cg16797762 chr3:3221439 CRBN 0.6 6.14 0.35 2.93e-9 White matter integrity; CESC cis rs2404602 0.735 rs2280306 chr15:76652258 C/G cg23625390 chr15:77176239 SCAPER -0.42 -5.62 -0.33 4.79e-8 Blood metabolite levels; CESC cis rs2050392 0.931 rs2265189 chr10:30689316 C/T cg18806716 chr10:30721971 MAP3K8 0.38 5.45 0.32 1.14e-7 Inflammatory bowel disease; CESC cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.15e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13775627 chr19:15483883 AKAP8 -0.57 -6.48 -0.37 4.41e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.8 9.17 0.49 1.33e-17 Alzheimer's disease; CESC cis rs933688 0.938 rs6869048 chr5:90664322 G/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 16.97 0.72 3.28e-44 Smoking behavior; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg25274881 chr12:49761165 SPATS2 0.46 6.23 0.36 1.8e-9 Thyroid stimulating hormone; CESC cis rs10979 0.546 rs9496686 chr6:143908735 G/C cg25407410 chr6:143891975 LOC285740 -0.49 -6.57 -0.37 2.58e-10 Hypospadias; CESC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg16145915 chr7:1198662 ZFAND2A -0.47 -5.39 -0.31 1.56e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.43 5.64 0.33 4.33e-8 Tonsillectomy; CESC cis rs8002861 0.905 rs6561149 chr13:44456782 T/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.47 -6.02 -0.35 5.84e-9 Leprosy; CESC trans rs1541692 0.507 rs250151 chr16:79591279 A/G cg07251046 chr12:97791023 NA 0.41 6.19 0.36 2.23e-9 Post bronchodilator FEV1/FVC ratio; CESC cis rs9287719 0.967 rs11687023 chr2:10741412 G/A cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs9486719 0.948 rs11152970 chr6:96909077 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -8.21 -0.45 9.55e-15 Migraine;Coronary artery disease; CESC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.53 -5.89 -0.34 1.19e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs68170813 0.559 rs6971675 chr7:106833797 G/A cg02696742 chr7:106810147 HBP1 -0.53 -5.06 -0.3 7.95e-7 Coronary artery disease; CESC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg13647721 chr17:30228624 UTP6 0.53 5.45 0.32 1.17e-7 Hip circumference adjusted for BMI; CESC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg15105969 chr2:36825350 FEZ2 0.54 6.67 0.38 1.53e-10 Height; CESC cis rs7714584 1.000 rs4958843 chr5:150224924 T/C cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.07 10.75 0.55 1.35e-22 Platelet count; CESC cis rs9309473 0.950 rs6546853 chr2:73833739 G/A cg20560298 chr2:73613845 ALMS1 -0.45 -6.03 -0.35 5.44e-9 Metabolite levels; CESC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg22800045 chr5:56110881 MAP3K1 0.44 5.36 0.31 1.84e-7 Coronary artery disease; CESC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.7 0.38 1.22e-10 Bipolar disorder; CESC cis rs12586317 0.547 rs3759548 chr14:35450333 C/T cg16230307 chr14:35515116 FAM177A1 0.99 10.62 0.55 3.38e-22 Psoriasis; CESC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg24675658 chr1:53192096 ZYG11B -0.67 -9.52 -0.5 1.17e-18 Monocyte count; CESC cis rs12926788 0.689 rs7186308 chr16:24848471 A/G cg04756594 chr16:24857601 SLC5A11 0.47 5.75 0.33 2.44e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs2235573 0.527 rs139884 chr22:38369976 A/G cg19894588 chr14:64061835 NA 0.63 8.28 0.45 6.09e-15 Glioblastoma;Glioma; CESC trans rs1973993 0.691 rs11165623 chr1:96893000 G/A cg10631902 chr5:14652156 NA 0.56 8.07 0.44 2.4e-14 Weight; CESC cis rs4919694 1.000 rs75219158 chr10:104747594 C/T cg04362960 chr10:104952993 NT5C2 0.72 5.63 0.33 4.66e-8 Arsenic metabolism; CESC cis rs473651 0.904 rs551859 chr2:239371836 T/C cg21699342 chr2:239360505 ASB1 0.54 9.2 0.49 1.07e-17 Multiple system atrophy; CESC cis rs60154123 0.614 rs646512 chr1:210453938 C/T cg22029157 chr1:209979665 IRF6 -0.45 -5.96 -0.34 8.05e-9 Coronary artery disease; CESC trans rs877282 0.898 rs35743076 chr10:758991 C/T cg22713356 chr15:30763199 NA 1.13 10.93 0.56 3.42e-23 Uric acid levels; CESC cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg21573476 chr21:45109991 RRP1B -0.5 -6.84 -0.39 5.38e-11 Mean corpuscular volume; CESC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg04025307 chr7:1156635 C7orf50 0.4 5.66 0.33 3.97e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs9329221 0.510 rs6995837 chr8:9975675 T/C cg06636001 chr8:8085503 FLJ10661 0.49 6.2 0.36 2.18e-9 Neuroticism; CESC cis rs1707322 1.000 rs4073847 chr1:46463012 A/C cg03146154 chr1:46216737 IPP -0.7 -9.32 -0.5 4.71e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs941408 1.000 rs1076447 chr19:2792128 C/G cg00079169 chr19:2811669 THOP1 0.45 6.28 0.36 1.35e-9 Total cholesterol levels; CESC cis rs854765 0.618 rs8066982 chr17:17851377 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg16339924 chr4:17578868 LAP3 0.64 8.06 0.44 2.71e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9814567 1.000 rs1138273 chr3:134261437 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.37 -0.36 8.41e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs59948050 1 rs59948050 chr1:15915157 T/G cg13390004 chr1:15929781 NA 0.41 5.13 0.3 5.68e-7 Morning vs. evening chronotype; CESC cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg03060546 chr3:49711283 APEH 0.43 5.27 0.31 2.85e-7 Parkinson's disease; CESC cis rs11098499 0.954 rs1480931 chr4:120395809 G/T cg09307838 chr4:120376055 NA 0.91 12.92 0.62 6.07e-30 Corneal astigmatism; CESC trans rs6142102 0.812 rs6120440 chr20:32517585 A/G cg09222884 chr3:49764367 IP6K1 0.55 6.3 0.36 1.25e-9 Skin pigmentation; CESC cis rs27434 0.607 rs34750 chr5:96142806 G/C cg16492584 chr5:96139282 ERAP1 -0.37 -5.31 -0.31 2.34e-7 Ankylosing spondylitis; CESC cis rs910316 1.000 rs12879542 chr14:75507525 C/T cg08847533 chr14:75593920 NEK9 0.99 18.02 0.74 6.08e-48 Height; CESC cis rs7429990 0.965 rs319696 chr3:47943861 T/C cg11946769 chr3:48343235 NME6 0.46 5.62 0.33 4.91e-8 Educational attainment (years of education); CESC cis rs11676348 0.818 rs6436031 chr2:218979259 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.04 -0.35 5.28e-9 Ulcerative colitis; CESC cis rs9309473 0.500 rs6546862 chr2:73860348 G/A cg20560298 chr2:73613845 ALMS1 0.51 7.22 0.41 5.57e-12 Metabolite levels; CESC cis rs644799 0.511 rs12791736 chr11:95475399 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.65 9.04 0.49 3.47e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg18769074 chr3:133464867 TF 0.31 6.05 0.35 4.95e-9 Iron status biomarkers (transferrin levels); CESC cis rs17376456 0.825 rs17372057 chr5:93071916 C/A cg25358565 chr5:93447407 FAM172A 1.1 10.97 0.56 2.4e-23 Diabetic retinopathy; CESC cis rs34779708 0.733 rs7914560 chr10:35548099 G/A cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs752010 0.871 rs10789405 chr1:42101962 C/T cg06885757 chr1:42089581 HIVEP3 0.49 7.94 0.44 5.63e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg10150615 chr22:24372951 LOC391322 0.48 6.22 0.36 1.88e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14118453 chr2:28613762 NA 0.44 6.05 0.35 4.95e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9325144 0.647 rs12227834 chr12:38849246 G/C cg26384229 chr12:38710491 ALG10B -0.56 -7.89 -0.44 8.02e-14 Morning vs. evening chronotype; CESC trans rs61931739 0.853 rs11053002 chr12:34083499 T/C cg26384229 chr12:38710491 ALG10B -0.45 -6.04 -0.35 5.32e-9 Morning vs. evening chronotype; CESC cis rs2576037 0.796 rs2576043 chr18:44573476 C/G cg19077165 chr18:44547161 KATNAL2 0.53 7.47 0.42 1.19e-12 Personality dimensions; CESC cis rs1153858 1.000 rs4774579 chr15:45651803 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.97 0.34 7.62e-9 Homoarginine levels; CESC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.96e-7 Life satisfaction; CESC cis rs2380220 0.576 rs7751219 chr6:96018915 G/A cg04719120 chr6:96025338 MANEA 0.64 6.88 0.39 4.28e-11 Behavioural disinhibition (generation interaction); CESC cis rs6088590 0.550 rs12624640 chr20:32952125 G/A cg24642439 chr20:33292090 TP53INP2 0.64 8.14 0.45 1.6e-14 Coronary artery disease; CESC cis rs10242455 0.702 rs917152 chr7:99004497 T/C cg18809830 chr7:99032528 PTCD1 -0.91 -6.35 -0.36 9.52e-10 Blood metabolite levels; CESC cis rs7188697 0.922 rs6499962 chr16:58610750 A/C cg02549819 chr16:58548995 SETD6 0.44 5.43 0.32 1.26e-7 QT interval; CESC cis rs8114671 0.527 rs6060068 chr20:33415820 T/A cg06115741 chr20:33292138 TP53INP2 0.45 5.31 0.31 2.37e-7 Height; CESC cis rs4474465 0.920 rs7396701 chr11:78202699 A/C cg27205649 chr11:78285834 NARS2 0.44 5.62 0.33 4.83e-8 Alzheimer's disease (survival time); CESC cis rs854765 0.583 rs9908832 chr17:17871068 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.65 9.38 0.5 3e-18 Total body bone mineral density; CESC cis rs3105593 0.555 rs3131568 chr15:50757721 C/T cg08437265 chr15:50716283 USP8 0.48 6.43 0.37 5.82e-10 QT interval; CESC cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg14345882 chr6:26364793 BTN3A2 0.42 5.3 0.31 2.41e-7 Intelligence (multi-trait analysis); CESC cis rs1153858 1.000 rs67744121 chr15:45677237 C/G cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13108601 chr6:41748242 FRS3;PRICKLE4 0.51 6.78 0.38 7.73e-11 Systemic lupus erythematosus; CESC cis rs4481887 0.927 rs4292985 chr1:248473692 T/A cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs3741404 0.609 rs592271 chr11:63872029 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 9.9 0.52 7.1e-20 Platelet count; CESC cis rs7100689 0.753 rs2185426 chr10:82120887 G/A cg00277334 chr10:82204260 NA -0.59 -7.35 -0.41 2.39e-12 Post bronchodilator FEV1; CESC cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg13206674 chr6:150067644 NUP43 0.43 6.04 0.35 5.17e-9 Lung cancer; CESC cis rs9457247 1.000 rs415890 chr6:167406633 C/G cg25258033 chr6:167368657 RNASET2 -0.39 -5.9 -0.34 1.09e-8 Crohn's disease; CESC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.19 -0.3 4.14e-7 Developmental language disorder (linguistic errors); CESC cis rs7179456 0.545 rs2250583 chr15:59050382 C/T cg05156742 chr15:59063176 FAM63B -0.64 -8.46 -0.46 1.79e-15 Asperger disorder; CESC cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg14784868 chr12:69753453 YEATS4 0.85 13.23 0.63 5.24e-31 Blood protein levels; CESC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg17971929 chr21:40555470 PSMG1 0.86 12.77 0.62 1.93e-29 Cognitive function; CESC cis rs597539 0.727 rs632984 chr11:68620271 C/T cg04772025 chr11:68637568 NA 0.51 5.75 0.33 2.43e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg11812906 chr14:75593930 NEK9 0.83 13.51 0.64 5.28e-32 Height; CESC cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg17366294 chr4:99064904 C4orf37 -0.57 -8.31 -0.45 5.08e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.95 0.48 6.42e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 -0.89 -13.73 -0.64 9.32e-33 Platelet count; CESC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg17372223 chr3:52568218 NT5DC2 0.43 6.16 0.35 2.7e-9 Bipolar disorder; CESC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.54 5.98 0.34 7.12e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7727544 0.735 rs272875 chr5:131674888 T/C cg24060327 chr5:131705240 SLC22A5 -0.66 -8.88 -0.48 1.04e-16 Blood metabolite levels; CESC cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.69 0.33 3.38e-8 Personality dimensions; CESC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg05564831 chr3:52568323 NT5DC2 0.45 6.84 0.39 5.32e-11 Bipolar disorder; CESC cis rs26868 0.690 rs26835 chr16:2237549 C/T cg02248941 chr16:2239361 CASKIN1 0.55 10.21 0.53 7.4e-21 Height; CESC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg06074448 chr4:187884817 NA -0.46 -7.12 -0.4 9.97e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.81 0.34 1.79e-8 Bipolar disorder; CESC cis rs9815354 0.680 rs73073280 chr3:42025772 T/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs9457247 0.967 rs2149083 chr6:167370971 G/C cg23791538 chr6:167370224 RNASET2 0.61 8.62 0.47 6.14e-16 Crohn's disease; CESC cis rs7980687 0.657 rs2851447 chr12:123665113 G/C cg00376283 chr12:123451042 ABCB9 0.67 9.28 0.5 6.47e-18 Height;Educational attainment;Head circumference (infant); CESC cis rs4711336 0.967 rs4711338 chr6:33660188 T/C cg14003231 chr6:33640908 ITPR3 0.32 5.42 0.32 1.34e-7 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00549575 chr11:8008752 EIF3F 0.51 6.95 0.39 2.77e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg10541313 chr22:46663664 TTC38 0.59 5.05 0.3 8.15e-7 LDL cholesterol;Cholesterol, total; CESC cis rs3820928 0.874 rs2272198 chr2:227893017 A/G cg11843606 chr2:227700838 RHBDD1 0.44 5.41 0.32 1.44e-7 Pulmonary function; CESC cis rs9905704 0.846 rs304262 chr17:56814456 A/G cg12560992 chr17:57184187 TRIM37 0.62 7.77 0.43 1.77e-13 Testicular germ cell tumor; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg00602891 chr17:80408864 C17orf62 -0.49 -6.52 -0.37 3.44e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.27 -0.31 2.79e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7923452 0.938 rs34930615 chr10:30761051 G/A cg25182066 chr10:30743637 MAP3K8 0.49 5.44 0.32 1.19e-7 Itch intensity from mosquito bite; CESC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.93 0.34 9.38e-9 Bipolar disorder; CESC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg09509183 chr1:209979624 IRF6 0.36 5.03 0.3 8.96e-7 Monobrow; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24103018 chr19:17420930 DDA1 -0.46 -6.02 -0.35 5.74e-9 Ulcerative colitis; CESC cis rs3096299 0.606 rs4785674 chr16:89536613 A/G cg16743903 chr16:89593216 SPG7 -0.47 -5.78 -0.33 2.06e-8 Multiple myeloma (IgH translocation); CESC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg16928487 chr17:17741425 SREBF1 0.53 8.96 0.48 6.08e-17 Total body bone mineral density; CESC cis rs9479482 0.648 rs912558 chr6:150385730 G/T cg03788504 chr6:150331562 NA 0.3 6.03 0.35 5.42e-9 Alopecia areata; CESC cis rs9287719 0.774 rs4997811 chr2:10755538 T/C cg00105475 chr2:10696890 NA 0.37 5.2 0.3 3.96e-7 Prostate cancer; CESC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg24060327 chr5:131705240 SLC22A5 -0.41 -5.15 -0.3 5.16e-7 Breast cancer; CESC cis rs7618501 0.521 rs55692411 chr3:49911155 G/A cg24110177 chr3:50126178 RBM5 -0.54 -7.23 -0.41 5.23e-12 Intelligence (multi-trait analysis); CESC cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg18252515 chr7:66147081 NA -1.3 -13.17 -0.63 8.35e-31 Diabetic kidney disease; CESC cis rs12476592 0.602 rs262538 chr2:63908025 A/T cg17519650 chr2:63277830 OTX1 0.49 5.37 0.31 1.68e-7 Childhood ear infection; CESC cis rs3793683 0.597 rs12767469 chr10:134587261 C/G cg27286337 chr10:134555280 INPP5A 0.7 8.12 0.45 1.8e-14 Migraine; CESC cis rs13064411 0.696 rs6798938 chr3:113218206 C/T cg18753928 chr3:113234510 CCDC52 -0.53 -6.33 -0.36 1.05e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs10911251 0.546 rs944971 chr1:183112505 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.22 0.63 5.53e-31 Colorectal cancer; CESC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg04267008 chr7:1944627 MAD1L1 -0.53 -6.57 -0.37 2.69e-10 Bipolar disorder and schizophrenia; CESC trans rs12599106 0.707 rs2163977 chr16:34916134 A/G cg07332563 chr6:291687 DUSP22 -0.63 -7.96 -0.44 4.97e-14 Menopause (age at onset); CESC cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1034591 0.715 rs12705991 chr7:114417612 A/C cg05338976 chr7:114561850 MDFIC -0.35 -5.04 -0.3 8.77e-7 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs11608355 0.597 rs10850070 chr12:109793882 A/G cg19025524 chr12:109796872 NA -0.54 -7.99 -0.44 4.03e-14 Neuroticism; CESC trans rs11191205 0.644 rs10883665 chr10:103374233 G/A cg12418535 chr2:119607192 EN1 -0.4 -6.0 -0.35 6.56e-9 Intelligence (multi-trait analysis); CESC cis rs258892 0.895 rs10059897 chr5:72080538 C/T cg21869765 chr5:72125136 TNPO1 -0.44 -5.52 -0.32 8.21e-8 Small cell lung carcinoma; CESC cis rs1538970 0.962 rs9429072 chr1:45810091 C/T cg24296786 chr1:45957014 TESK2 0.42 5.05 0.3 8.29e-7 Platelet count; CESC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg11764359 chr7:65958608 NA 0.81 11.94 0.59 1.36e-26 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19476186 chr20:3869959 PANK2 0.55 6.24 0.36 1.69e-9 Gut microbiome composition (summer); CESC cis rs6815814 0.950 rs113465719 chr4:38808045 A/T cg02016764 chr4:38805732 TLR1 -0.63 -7.26 -0.41 4.22e-12 Breast cancer; CESC cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.13 0.3 5.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12900413 0.687 rs28475471 chr15:90311749 C/T cg24249390 chr15:90295951 MESP1 -0.41 -5.63 -0.33 4.51e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs4141404 0.737 rs5998067 chr22:32043630 C/T cg00478049 chr22:31556069 RNF185 0.49 6.0 0.35 6.54e-9 Paclitaxel-induced neuropathy; CESC cis rs56046484 0.956 rs2174218 chr15:85624656 C/G cg08123816 chr15:85640762 PDE8A 0.48 6.05 0.35 4.86e-9 Testicular germ cell tumor; CESC cis rs7216064 1.000 rs7221651 chr17:65832390 A/G cg07042672 chr17:66097459 LOC651250 0.57 6.64 0.38 1.74e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs4245128 0.862 rs1892978 chr11:112796011 G/T cg10894232 chr8:11772343 NA 0.37 6.06 0.35 4.59e-9 Life satisfaction; CESC cis rs9902453 0.904 rs7225686 chr17:28356744 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.69 -0.47 3.79e-16 Coffee consumption (cups per day); CESC cis rs12893668 0.673 rs2296482 chr14:104029819 T/G cg24130564 chr14:104152367 KLC1 -0.48 -5.89 -0.34 1.19e-8 Reticulocyte count; CESC cis rs6032067 0.929 rs62208428 chr20:43827578 A/C cg10761708 chr20:43804764 PI3 0.53 6.36 0.36 8.83e-10 Blood protein levels; CESC cis rs6815814 0.851 rs11466617 chr4:38780471 T/C cg02016764 chr4:38805732 TLR1 -0.68 -8.15 -0.45 1.45e-14 Breast cancer; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg07322296 chr22:50661779 TUBGCP6 -0.44 -6.01 -0.35 6.15e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg17971929 chr21:40555470 PSMG1 -0.87 -12.9 -0.62 7.25e-30 Cognitive function; CESC cis rs2760061 0.626 rs2527615 chr1:228119283 A/G cg01973587 chr1:228161476 NA 0.37 5.66 0.33 3.89e-8 Diastolic blood pressure; CESC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg19346786 chr7:2764209 NA -0.47 -7.18 -0.4 7.19e-12 Height; CESC cis rs10887741 0.646 rs1358863 chr10:89426508 T/G cg13926569 chr10:89418898 PAPSS2 0.48 7.42 0.41 1.55e-12 Exercise (leisure time); CESC cis rs3092073 0.624 rs11906879 chr20:44591324 C/T cg00125455 chr20:44574271 PCIF1 -0.39 -6.3 -0.36 1.25e-9 Intelligence (multi-trait analysis); CESC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg03806693 chr22:41940476 POLR3H -1.16 -13.77 -0.65 6.87e-33 Vitiligo; CESC cis rs2635047 0.615 rs9304343 chr18:44720664 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.42 -5.21 -0.3 3.89e-7 Educational attainment; CESC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg23281280 chr6:28129359 ZNF389 0.43 6.41 0.37 6.46e-10 Cardiac Troponin-T levels; CESC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg03576123 chr11:487126 PTDSS2 -1.12 -10.56 -0.54 5.45e-22 Body mass index; CESC cis rs7772486 0.686 rs9390348 chr6:146044748 C/T cg23711669 chr6:146136114 FBXO30 -0.87 -12.9 -0.62 7e-30 Lobe attachment (rater-scored or self-reported); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg12476490 chr10:64576179 EGR2 -0.41 -6.29 -0.36 1.31e-9 Vertical cup-disc ratio; CESC cis rs2073300 0.609 rs79250740 chr20:23417165 G/A cg16736954 chr20:23401023 NAPB 0.78 5.78 0.33 2.05e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs11577318 0.853 rs3795684 chr1:26632781 C/T cg18121669 chr1:26560928 CCDC21 0.43 5.1 0.3 6.41e-7 Granulocyte percentage of myeloid white cells; CESC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg26850624 chr5:429559 AHRR -0.5 -6.69 -0.38 1.35e-10 Cystic fibrosis severity; CESC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg08888203 chr3:10149979 C3orf24 0.51 6.39 0.37 7.29e-10 Alzheimer's disease; CESC cis rs11764590 0.694 rs11773643 chr7:2104063 A/G cg21782813 chr7:2030301 MAD1L1 -0.41 -5.3 -0.31 2.42e-7 Neuroticism; CESC cis rs1707322 0.752 rs6662164 chr1:46146230 T/A cg05343316 chr1:45956843 TESK2 0.48 5.97 0.34 7.4e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4144743 0.938 rs55677902 chr17:45322572 G/T cg18085866 chr17:45331354 ITGB3 -0.64 -7.01 -0.4 1.92e-11 Body mass index; CESC cis rs4604732 0.631 rs12036460 chr1:247626928 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.7 -8.01 -0.44 3.69e-14 Gut microbiome composition (summer); CESC cis rs60154123 0.667 rs650854 chr1:210465315 G/C cg23283495 chr1:209979779 IRF6 0.42 5.46 0.32 1.08e-7 Coronary artery disease; CESC cis rs4727963 0.846 rs2402626 chr7:122712358 C/T cg03640110 chr7:122635026 TAS2R16 0.38 5.87 0.34 1.28e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs637571 0.522 rs491973 chr11:65727301 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.48 6.51 0.37 3.66e-10 Eosinophil percentage of white cells; CESC cis rs4423214 0.650 rs2186777 chr11:71219803 C/A cg05163923 chr11:71159392 DHCR7 0.73 9.19 0.49 1.19e-17 Vitamin D levels; CESC cis rs644799 0.965 rs502521 chr11:95533557 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.91 13.69 0.64 1.25e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg26314531 chr2:26401878 FAM59B 0.7 7.47 0.42 1.17e-12 Gut microbiome composition (summer); CESC cis rs9549367 0.789 rs3764125 chr13:113897648 A/G cg18105134 chr13:113819100 PROZ 0.77 9.03 0.49 3.55e-17 Platelet distribution width; CESC cis rs6831352 0.840 rs35073321 chr4:100053276 G/A cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs11645898 0.748 rs11647889 chr16:72052034 C/G cg14768367 chr16:72042858 DHODH -0.82 -6.66 -0.38 1.6e-10 Blood protein levels; CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg07507251 chr3:52567010 NT5DC2 0.48 9.22 0.49 9.4e-18 Electroencephalogram traits; CESC cis rs11657217 1.000 rs8081537 chr17:77708264 A/G cg06901238 chr17:77706717 ENPP7 0.41 5.47 0.32 1.03e-7 Diastolic blood pressure response to hydrochlorothiazide in hypertension; CESC cis rs7949030 0.588 rs2509961 chr11:62310909 T/C cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.4 -0.31 1.52e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs317689 0.658 rs479971 chr12:69672471 A/G cg14784868 chr12:69753453 YEATS4 0.48 5.03 0.3 8.88e-7 Response to diuretic therapy; CESC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg10691866 chr7:65817282 TPST1 -0.33 -5.23 -0.31 3.46e-7 Aortic root size; CESC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg00129232 chr17:37814104 STARD3 -0.51 -6.41 -0.37 6.79e-10 Glomerular filtration rate (creatinine); CESC cis rs11997175 0.766 rs60855034 chr8:33684732 G/A ch.8.33884649F chr8:33765107 NA 0.45 5.71 0.33 2.95e-8 Body mass index; CESC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg19346786 chr7:2764209 NA -0.46 -6.64 -0.38 1.78e-10 Height; CESC cis rs7818688 1.000 rs11786380 chr8:96028136 A/G cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18635645 chr1:85667791 SYDE2 0.5 6.85 0.39 5.23e-11 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2573652 1.000 rs1469829 chr15:100517332 A/G cg00587665 chr15:100533223 ADAMTS17 -0.37 -5.81 -0.34 1.81e-8 Height; CESC cis rs10129255 0.500 rs10143242 chr14:107137831 C/T cg07958169 chr14:107095056 NA -0.53 -8.53 -0.46 1.11e-15 Kawasaki disease; CESC cis rs8180040 0.726 rs2061197 chr3:47001350 C/T cg27129171 chr3:47204927 SETD2 -0.63 -8.62 -0.47 6.27e-16 Colorectal cancer; CESC cis rs2708240 0.666 rs1861010 chr7:147601401 G/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.18e-8 QT interval (drug interaction); CESC cis rs2749592 0.513 rs1208708 chr10:38085576 A/G cg00409905 chr10:38381863 ZNF37A -0.43 -5.91 -0.34 1.03e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs5747327 0.874 rs713701 chr22:18131546 A/G cg19898043 chr22:18121309 BCL2L13 -0.4 -5.04 -0.3 8.47e-7 Myeloid white cell count;Granulocyte count; CESC cis rs34779708 0.966 rs34630580 chr10:35449228 A/G cg03585969 chr10:35415529 CREM 0.76 10.16 0.53 1.1e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg14893161 chr1:205819251 PM20D1 -0.48 -6.6 -0.38 2.28e-10 Menarche (age at onset); CESC cis rs734999 0.545 rs7368105 chr1:2556548 C/T cg18854424 chr1:2615690 NA 0.31 5.91 0.34 1.08e-8 Ulcerative colitis; CESC cis rs7605827 0.897 rs2241238 chr2:15656560 T/C cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.65e-10 Educational attainment (years of education); CESC cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9926296 0.533 rs12102297 chr16:89812762 C/A cg27121462 chr16:89883253 FANCA 0.82 12.28 0.6 9.91e-28 Vitiligo; CESC cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs524281 0.861 rs7929909 chr11:65951698 C/T cg14036092 chr11:66035641 RAB1B -0.56 -5.57 -0.32 6.24e-8 Electroencephalogram traits; CESC cis rs12136530 0.593 rs12121242 chr1:19740609 G/C cg01832549 chr1:19774989 CAPZB -0.43 -6.13 -0.35 3.09e-9 Lead levels in blood; CESC cis rs8062405 0.755 rs4787456 chr16:28559573 C/T cg01378222 chr16:28622494 SULT1A1 0.3 5.14 0.3 5.27e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10611753 chr15:55489541 RSL24D1 -0.5 -7.83 -0.43 1.15e-13 Gambling; CESC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg11644478 chr21:40555479 PSMG1 -0.52 -7.16 -0.4 7.99e-12 Menarche (age at onset); CESC cis rs11809207 0.501 rs2232654 chr1:26496870 A/G cg00147160 chr1:26503991 CNKSR1 0.28 5.35 0.31 1.88e-7 Height; CESC cis rs7772486 0.686 rs6570705 chr6:145961201 C/T cg05347473 chr6:146136440 FBXO30 0.53 6.88 0.39 4.42e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs77861329 0.669 rs2878438 chr3:52103045 A/G cg08692210 chr3:52188851 WDR51A 0.49 5.85 0.34 1.47e-8 Macrophage inflammatory protein 1b levels; CESC cis rs1707322 1.000 rs1612419 chr1:46546945 T/C cg05343316 chr1:45956843 TESK2 -0.47 -5.49 -0.32 9.29e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11367841 chr11:47270567 NR1H3;ACP2 -0.43 -6.05 -0.35 4.99e-9 Gambling; CESC cis rs9291683 0.527 rs73212848 chr4:10093299 T/C cg00071950 chr4:10020882 SLC2A9 -0.67 -11.05 -0.56 1.36e-23 Bone mineral density; CESC cis rs7274811 0.652 rs291686 chr20:32010851 T/C cg21523528 chr20:32077966 CBFA2T2 -0.44 -5.15 -0.3 5.02e-7 Height; CESC cis rs9911578 1.000 rs6503887 chr17:56993320 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.41 5.41 0.32 1.38e-7 Intelligence (multi-trait analysis); CESC cis rs7635838 0.892 rs7644968 chr3:11489493 C/T cg00170343 chr3:11313890 ATG7 0.42 5.68 0.33 3.57e-8 HDL cholesterol; CESC trans rs523522 0.962 rs2235218 chr12:120888619 A/C cg02849695 chr1:159869960 CCDC19 0.34 6.05 0.35 5.03e-9 High light scatter reticulocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23041619 chr2:27435357 SLC5A6;C2orf28 -0.44 -6.89 -0.39 4.06e-11 Gambling; CESC cis rs1348850 0.540 rs6737342 chr2:178419117 G/A cg23306229 chr2:178417860 TTC30B 0.78 7.56 0.42 6.56e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11168351 0.833 rs6580652 chr12:48447105 C/A cg04545296 chr12:48745243 ZNF641 -0.36 -6.23 -0.36 1.86e-9 Bipolar disorder and schizophrenia; CESC cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.99 0.56 2.15e-23 Hip circumference adjusted for BMI; CESC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg18404041 chr3:52824283 ITIH1 0.41 6.88 0.39 4.41e-11 Bipolar disorder; CESC cis rs11690935 1.000 rs6721680 chr2:172543913 G/T cg13550731 chr2:172543902 DYNC1I2 1.0 16.61 0.71 5.86e-43 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24087447 chr12:133202758 POLE 0.49 6.7 0.38 1.22e-10 Fibrinogen levels; CESC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg00310523 chr12:86230176 RASSF9 0.35 5.44 0.32 1.21e-7 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16512924 chr15:28394682 HERC2 -0.62 -6.78 -0.38 7.63e-11 Gut microbiome composition (summer); CESC trans rs72996113 0.702 rs11224354 chr11:100519749 G/A cg20136100 chr11:63974860 FERMT3 -0.52 -6.58 -0.37 2.56e-10 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs1797885 0.564 rs959088 chr3:12582138 G/C cg26432171 chr3:12704882 RAF1 -0.53 -6.93 -0.39 3.27e-11 Immature fraction of reticulocytes; CESC cis rs36051895 0.589 rs12682672 chr9:5187941 T/C cg02405213 chr9:5042618 JAK2 -0.54 -6.6 -0.38 2.25e-10 Pediatric autoimmune diseases; CESC cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.58e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7851660 0.874 rs1955144 chr9:100634589 A/G cg13688889 chr9:100608707 NA -0.6 -8.55 -0.47 9.84e-16 Strep throat; CESC cis rs763014 0.931 rs3752567 chr16:628130 A/G cg07256732 chr16:621771 PIGQ -0.3 -5.13 -0.3 5.48e-7 Height; CESC cis rs12422267 0.536 rs11831679 chr12:132609960 C/T cg09764611 chr12:132620959 NA -0.52 -6.7 -0.38 1.28e-10 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg22875332 chr1:76189707 ACADM 0.66 7.84 0.43 1.1e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs17376456 0.877 rs35075119 chr5:93385457 T/C cg25358565 chr5:93447407 FAM172A 1.11 11.19 0.57 4.56e-24 Diabetic retinopathy; CESC cis rs7084402 0.935 rs10763556 chr10:60341398 A/G cg07615347 chr10:60278583 BICC1 -0.59 -9.17 -0.49 1.39e-17 Refractive error; CESC cis rs11828289 0.660 rs17306398 chr11:23192235 G/T cg20040320 chr11:23191996 NA 0.62 5.56 0.32 6.61e-8 Cancer; CESC cis rs2243480 1.000 rs6958289 chr7:65657111 T/G cg12463550 chr7:65579703 CRCP -0.73 -5.66 -0.33 4.03e-8 Diabetic kidney disease; CESC cis rs9611565 0.559 rs13056262 chr22:42081921 A/G cg06634786 chr22:41940651 POLR3H 0.62 6.25 0.36 1.67e-9 Vitiligo; CESC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.46 0.54 1.2e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg06203126 chr5:43313815 HMGCS1 -0.41 -6.2 -0.36 2.17e-9 Vertical cup-disc ratio; CESC cis rs2073300 1.000 rs6132626 chr20:23444672 T/C cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs66887589 0.807 rs9799664 chr4:120326678 C/T cg09307838 chr4:120376055 NA 0.52 7.01 0.4 1.95e-11 Diastolic blood pressure; CESC cis rs2742234 0.541 rs10899782 chr10:43736361 A/T cg15436174 chr10:43711423 RASGEF1A 0.45 5.13 0.3 5.72e-7 Hirschsprung disease; CESC cis rs12477438 0.520 rs11677247 chr2:99756358 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.46 0.69 7.45e-39 Chronic sinus infection; CESC cis rs12410462 0.581 rs7541809 chr1:227547299 G/A cg10327440 chr1:227177885 CDC42BPA -0.67 -5.69 -0.33 3.43e-8 Major depressive disorder; CESC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg22442454 chr1:209979470 IRF6 0.5 6.22 0.36 1.98e-9 Cleft lip with or without cleft palate; CESC cis rs9640161 0.750 rs1983440 chr7:150023941 G/C cg21361702 chr7:150065534 REPIN1 0.51 5.86 0.34 1.37e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg00101154 chr16:420108 MRPL28 -0.44 -5.13 -0.3 5.68e-7 Bone mineral density (spine);Bone mineral density; CESC cis rs5769765 1.000 rs8138941 chr22:50290678 G/A cg26441486 chr22:50317300 CRELD2 0.38 5.32 0.31 2.17e-7 Schizophrenia; CESC cis rs4481887 0.927 rs4381224 chr1:248456826 A/T cg00666640 chr1:248458726 OR2T12 0.41 6.84 0.39 5.57e-11 Common traits (Other); CESC cis rs4594175 0.926 rs11157800 chr14:51615502 A/T cg23942311 chr14:51606299 NA 0.37 5.68 0.33 3.55e-8 Cancer; CESC cis rs7223966 1.000 rs6504173 chr17:61735056 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.56 -0.32 6.64e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs11676348 0.811 rs13027120 chr2:219020914 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.42 5.4 0.31 1.47e-7 Ulcerative colitis; CESC cis rs9402673 0.517 rs978036 chr6:135342903 C/T cg24558204 chr6:135376177 HBS1L 0.52 7.29 0.41 3.48e-12 Reticulocyte count;High light scatter reticulocyte count; CESC cis rs9926296 0.656 rs4522419 chr16:89853307 T/C cg27121462 chr16:89883253 FANCA 0.55 6.49 0.37 4.14e-10 Vitiligo; CESC cis rs8018808 0.902 rs8006688 chr14:77926649 G/A cg20045696 chr14:77926864 AHSA1 0.42 5.75 0.33 2.45e-8 Myeloid white cell count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22866681 chr6:2685401 MYLK4 -0.46 -6.37 -0.36 8.24e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8017423 1.000 rs8017423 chr14:90679910 A/G cg14092571 chr14:90743983 NA -0.57 -8.5 -0.46 1.44e-15 Mortality in heart failure; CESC cis rs60843830 0.964 rs17713879 chr2:254215 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.86 11.77 0.59 5.28e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg17221315 chr6:27791827 HIST1H4J 0.43 5.72 0.33 2.88e-8 Cardiac Troponin-T levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04526987 chr8:131370329 ASAP1 -0.49 -6.82 -0.39 6.09e-11 Gut microbiota (bacterial taxa); CESC cis rs9611565 0.500 rs2011053 chr22:42121278 G/A cg03806693 chr22:41940476 POLR3H 0.76 9.28 0.5 6.17e-18 Vitiligo; CESC cis rs9910055 0.529 rs850851 chr17:42177674 C/T cg13607699 chr17:42295918 UBTF -0.44 -5.35 -0.31 1.89e-7 Total body bone mineral density; CESC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg00166722 chr3:10149974 C3orf24 0.48 6.16 0.35 2.64e-9 Alzheimer's disease; CESC cis rs7592578 0.679 rs4287794 chr2:191327147 T/C cg10560079 chr2:191398806 TMEM194B -0.55 -5.43 -0.32 1.28e-7 Diastolic blood pressure; CESC trans rs7980799 0.682 rs1384599 chr12:33624579 G/A cg26384229 chr12:38710491 ALG10B -0.58 -8.26 -0.45 7.19e-15 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs3008870 1.000 rs2985822 chr1:67404910 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.02 14.14 0.66 3.43e-34 Lymphocyte percentage of white cells; CESC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg11764359 chr7:65958608 NA -0.73 -9.8 -0.52 1.49e-19 Aortic root size; CESC cis rs400736 0.602 rs11121090 chr1:8168634 A/G cg25007680 chr1:8021821 PARK7 0.55 7.37 0.41 2.19e-12 Response to antidepressants and depression; CESC cis rs7937682 0.889 rs558736 chr11:111500760 C/G cg09085632 chr11:111637200 PPP2R1B -1.0 -15.84 -0.7 3.11e-40 Primary sclerosing cholangitis; CESC cis rs4727027 0.933 rs917123 chr7:148848358 G/A cg23583168 chr7:148888333 NA -0.81 -12.62 -0.61 6.75e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg13206674 chr6:150067644 NUP43 0.45 6.44 0.37 5.65e-10 Lung cancer; CESC cis rs2070488 0.775 rs7644530 chr3:38558316 C/T cg24069376 chr3:38537580 EXOG -0.34 -5.84 -0.34 1.49e-8 Electrocardiographic conduction measures; CESC cis rs8044868 0.530 rs7189115 chr16:72098952 C/T cg16558253 chr16:72132732 DHX38 -0.38 -5.87 -0.34 1.31e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs10751667 0.666 rs10902235 chr11:938892 T/C cg06064525 chr11:970664 AP2A2 -0.5 -10.04 -0.52 2.7e-20 Alzheimer's disease (late onset); CESC cis rs7481584 0.564 rs7948848 chr11:2981896 G/A cg25174290 chr11:3078921 CARS -0.51 -6.67 -0.38 1.46e-10 Calcium levels; CESC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.74 -0.33 2.6e-8 Total body bone mineral density; CESC cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg02487422 chr3:49467188 NICN1 0.48 6.16 0.35 2.75e-9 Parkinson's disease; CESC trans rs13398848 1.000 rs10190107 chr2:84201058 A/G cg23262351 chr6:79576851 IRAK1BP1 0.68 6.01 0.35 6.2e-9 Conduct disorder (symptom count);Conduct disorder; CESC cis rs4319547 1.000 rs4319547 chr12:123079035 A/G cg23029597 chr12:123009494 RSRC2 -0.5 -5.55 -0.32 7.09e-8 Body mass index; CESC cis rs67311347 1.000 rs4128740 chr3:40519532 C/A cg24209194 chr3:40518798 ZNF619 0.49 6.1 0.35 3.73e-9 Renal cell carcinoma; CESC cis rs2404602 0.692 rs12910382 chr15:77053442 A/C cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs17601876 0.814 rs2899474 chr15:51562076 C/T cg19946085 chr15:51559439 CYP19A1 -0.33 -5.2 -0.3 4.03e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg11695030 chr19:34919128 UBA2 -0.44 -6.06 -0.35 4.57e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs225245 0.817 rs1049379 chr17:33998802 G/C cg05299278 chr17:33885742 SLFN14 0.35 5.07 0.3 7.61e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs12956009 0.583 rs9653018 chr18:44895853 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.5 0.37 3.94e-10 Educational attainment (years of education); CESC cis rs8062405 0.824 rs7191618 chr16:28565667 C/G cg08761264 chr16:28874980 SH2B1 -0.42 -5.07 -0.3 7.33e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs5769765 0.730 rs62233964 chr22:50317410 C/G cg26441486 chr22:50317300 CRELD2 0.47 5.66 0.33 3.99e-8 Schizophrenia; CESC cis rs2625529 0.586 rs59975112 chr15:72423710 G/T cg16672083 chr15:72433130 SENP8 0.44 6.7 0.38 1.21e-10 Red blood cell count; CESC cis rs71403859 0.502 rs36122765 chr16:71504183 G/C cg08717414 chr16:71523259 ZNF19 -0.99 -9.42 -0.5 2.36e-18 Post bronchodilator FEV1; CESC cis rs5769707 0.846 rs5770610 chr22:50036897 A/C cg20744362 chr22:50050164 C22orf34 0.48 8.27 0.45 6.61e-15 Monocyte count;Monocyte percentage of white cells; CESC cis rs78707713 0.841 rs78677622 chr10:71196698 C/T cg12610070 chr10:71211762 TSPAN15 -0.44 -7.38 -0.41 2.08e-12 Venous thromboembolism; CESC cis rs116095464 0.558 rs7725227 chr5:233517 G/A cg22857025 chr5:266934 NA -1.28 -18.71 -0.75 2.24e-50 Breast cancer; CESC cis rs1003719 0.591 rs13046303 chr21:38551976 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.54 -6.96 -0.39 2.7e-11 Eye color traits; CESC cis rs10170846 0.800 rs10194743 chr2:223518151 A/G cg25565276 chr2:223520875 FARSB 0.55 7.71 0.43 2.51e-13 Schizophrenia (inflammation and infection response interaction); CESC cis rs8060686 0.641 rs113502835 chr16:68238965 A/T cg26727032 chr16:67993705 SLC12A4 -0.53 -5.95 -0.34 8.65e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs17270561 0.609 rs17267614 chr6:25730027 A/C cg17691542 chr6:26056736 HIST1H1C 0.41 5.34 0.31 1.96e-7 Iron status biomarkers; CESC cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03094905 chr4:52710562 DCUN1D4 -0.49 -6.18 -0.35 2.44e-9 Ulcerative colitis; CESC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg16145915 chr7:1198662 ZFAND2A -0.49 -5.45 -0.32 1.14e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7904368 0.754 rs12253908 chr10:16853358 T/C cg23933602 chr10:16859644 RSU1 0.68 5.81 0.34 1.78e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs67478160 0.634 rs2368558 chr14:104230518 A/G cg08213375 chr14:104286397 PPP1R13B 0.46 9.0 0.48 4.6e-17 Schizophrenia; CESC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg00684032 chr4:1343700 KIAA1530 0.61 9.15 0.49 1.53e-17 Obesity-related traits; CESC cis rs1008375 0.835 rs9760627 chr4:17651508 C/T cg16339924 chr4:17578868 LAP3 0.63 7.85 0.43 1.04e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1707322 1.000 rs11211248 chr1:46476844 A/G cg05343316 chr1:45956843 TESK2 0.43 5.24 0.31 3.24e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11792861 0.926 rs1044905 chr9:111781495 G/A cg14384093 chr9:111878565 C9orf5 -0.41 -5.05 -0.3 8.32e-7 Menarche (age at onset); CESC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg22823121 chr1:150693482 HORMAD1 0.37 5.17 0.3 4.53e-7 Melanoma; CESC cis rs9911578 0.741 rs2611776 chr17:56819636 G/T cg12560992 chr17:57184187 TRIM37 0.92 15.09 0.68 1.43e-37 Intelligence (multi-trait analysis); CESC cis rs72627123 0.867 rs73301475 chr14:74462868 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.77 5.34 0.31 2e-7 Morning vs. evening chronotype; CESC cis rs9549367 0.756 rs2316463 chr13:113901406 C/T cg00898013 chr13:113819073 PROZ -0.52 -7.11 -0.4 1.07e-11 Platelet distribution width; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22984404 chr17:30469399 RHOT1 -0.49 -6.52 -0.37 3.54e-10 Fibrinogen levels; CESC cis rs4332037 0.950 rs56403963 chr7:1946130 C/G cg23422044 chr7:1970798 MAD1L1 -0.53 -5.41 -0.32 1.44e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00081347 chr17:78188837 SGSH -0.56 -6.32 -0.36 1.08e-9 Gut microbiome composition (summer); CESC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg00684032 chr4:1343700 KIAA1530 0.41 5.84 0.34 1.49e-8 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14857596 chr12:72233493 TBC1D15 -0.48 -6.75 -0.38 9.22e-11 Fibrinogen levels; CESC trans rs9951602 0.512 rs7240758 chr18:76650677 T/C cg02800362 chr5:177631904 HNRNPAB 0.66 8.66 0.47 4.55e-16 Obesity-related traits; CESC cis rs6754311 0.608 rs3739020 chr2:136602491 T/G cg15123519 chr2:136567270 LCT -0.3 -5.14 -0.3 5.23e-7 Mosquito bite size; CESC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.65 0.38 1.63e-10 Bipolar disorder; CESC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.69 0.38 1.34e-10 Bipolar disorder; CESC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg24846343 chr22:24311635 DDTL 0.64 11.11 0.56 8.29e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7193541 0.684 rs4888265 chr16:74683737 T/C cg01733217 chr16:74700730 RFWD3 1.05 20.24 0.78 1.07e-55 Multiple myeloma; CESC cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg14345882 chr6:26364793 BTN3A2 -0.39 -5.23 -0.31 3.5e-7 Intelligence (multi-trait analysis); CESC cis rs11098499 0.954 rs6834796 chr4:120414693 A/C cg24375607 chr4:120327624 NA 0.46 5.66 0.33 3.97e-8 Corneal astigmatism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03449406 chr14:35183687 CFL2 -0.49 -6.71 -0.38 1.21e-10 Ulcerative colitis; CESC cis rs3768617 0.811 rs61808068 chr1:182979377 T/A ch.1.3577855R chr1:183094577 LAMC1 0.66 9.0 0.48 4.41e-17 Fuchs's corneal dystrophy; CESC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg17221315 chr6:27791827 HIST1H4J 0.46 6.09 0.35 3.98e-9 Cardiac Troponin-T levels; CESC cis rs12142240 0.698 rs17361805 chr1:46813967 C/T cg10495392 chr1:46806563 NSUN4 0.55 6.04 0.35 5.2e-9 Menopause (age at onset); CESC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg05564831 chr3:52568323 NT5DC2 -0.37 -5.34 -0.31 1.95e-7 Bipolar disorder; CESC cis rs3733585 0.673 rs4292333 chr4:9953871 G/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg19318889 chr4:1322082 MAEA -0.6 -7.46 -0.42 1.28e-12 Longevity; CESC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.76e-18 Skin colour saturation; CESC cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9430161 0.611 rs12081181 chr1:11034165 T/G cg02454025 chr1:11042201 C1orf127 0.96 15.32 0.69 2.28e-38 Ewing sarcoma; CESC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg26850624 chr5:429559 AHRR -0.49 -6.72 -0.38 1.08e-10 Cystic fibrosis severity; CESC cis rs2354432 0.607 rs55918563 chr1:146718973 G/C cg25205988 chr1:146714368 CHD1L -1.01 -8.47 -0.46 1.68e-15 Mitochondrial DNA levels; CESC cis rs7219021 1.000 rs11657371 chr17:46843873 T/C cg16584676 chr17:46985605 UBE2Z -0.69 -7.57 -0.42 6.15e-13 Schizophrenia or bipolar disorder; CESC trans rs61931739 0.534 rs1211286 chr12:34135581 T/C cg26384229 chr12:38710491 ALG10B 0.51 6.8 0.39 6.9e-11 Morning vs. evening chronotype; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06080712 chr22:32435515 NA -0.5 -7.01 -0.4 1.94e-11 Gut microbiota (bacterial taxa); CESC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09482975 chr15:55700768 CCPG1 -0.5 -6.4 -0.37 7.11e-10 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06464452 chr4:77227879 STBD1 -0.56 -6.63 -0.38 1.82e-10 Gut microbiome composition (summer); CESC cis rs920590 0.758 rs35280191 chr8:19665214 A/C cg17834443 chr8:19674713 INTS10 0.61 6.92 0.39 3.49e-11 Acute lymphoblastic leukemia (childhood); CESC trans rs8073060 0.544 rs9912939 chr17:34005264 T/G cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs4474465 0.850 rs4944203 chr11:78220629 A/C cg27205649 chr11:78285834 NARS2 0.44 5.27 0.31 2.83e-7 Alzheimer's disease (survival time); CESC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg22800045 chr5:56110881 MAP3K1 0.52 6.7 0.38 1.23e-10 Coronary artery disease; CESC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg24829409 chr8:58192753 C8orf71 -0.74 -9.93 -0.52 5.7e-20 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs2730245 0.636 rs710421 chr7:158668575 T/C cg01943577 chr7:158741284 NA -0.47 -6.26 -0.36 1.57e-9 Height; CESC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg16132339 chr22:24313637 DDTL;DDT 0.38 5.87 0.34 1.33e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC trans rs1814175 0.558 rs5025146 chr11:49795724 C/G cg03929089 chr4:120376271 NA -0.89 -13.75 -0.65 7.56e-33 Height; CESC cis rs11250464 0.736 rs5015512 chr10:1411923 T/C cg26394196 chr10:1453818 ADARB2 -0.43 -5.76 -0.33 2.37e-8 Radiation response; CESC cis rs317689 0.684 rs315125 chr12:69758884 C/T cg20891283 chr12:69753455 YEATS4 0.64 7.44 0.42 1.42e-12 Response to diuretic therapy; CESC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg07677032 chr17:61819896 STRADA -0.52 -6.99 -0.39 2.23e-11 Prudent dietary pattern; CESC cis rs910316 0.737 rs175077 chr14:75506875 G/A cg08847533 chr14:75593920 NEK9 -0.89 -14.97 -0.68 3.81e-37 Height; CESC cis rs5758511 0.680 rs5758657 chr22:42618669 A/G cg00645731 chr22:42541494 CYP2D7P1 0.59 8.76 0.47 2.44e-16 Birth weight; CESC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.74 0.64 8.59e-33 Prudent dietary pattern; CESC cis rs7551222 0.752 rs4951400 chr1:204534571 C/G cg20240347 chr1:204465584 NA -0.28 -5.66 -0.33 4.03e-8 Schizophrenia; CESC cis rs9815354 0.812 rs57162396 chr3:41896031 G/A cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.84e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs854765 0.618 rs9908017 chr17:17774422 C/T cg04398451 chr17:18023971 MYO15A 0.64 9.37 0.5 3.2e-18 Total body bone mineral density; CESC cis rs10870270 0.564 rs45519634 chr10:133782616 C/T cg17892150 chr10:133769511 PPP2R2D -0.85 -7.59 -0.42 5.3e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg00166722 chr3:10149974 C3orf24 0.47 5.97 0.34 7.77e-9 Alzheimer's disease; CESC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg11214544 chr1:2391121 NA -0.47 -7.24 -0.41 4.84e-12 Non-obstructive azoospermia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15104066 chr12:90102578 LOC338758 -0.46 -6.02 -0.35 5.84e-9 Fibrinogen levels; CESC cis rs11711311 1.000 rs2242109 chr3:113434100 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.71 10.16 0.53 1.07e-20 IgG glycosylation; CESC cis rs7560272 0.501 rs2421675 chr2:73955301 C/A cg20560298 chr2:73613845 ALMS1 0.41 5.63 0.33 4.63e-8 Schizophrenia; CESC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg26354017 chr1:205819088 PM20D1 0.87 13.82 0.65 4.49e-33 Menarche (age at onset); CESC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg00484396 chr16:3507460 NAT15 0.44 7.3 0.41 3.33e-12 Tuberculosis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08862778 chr1:11322643 MTOR 0.45 6.12 0.35 3.36e-9 Systemic lupus erythematosus; CESC cis rs2249694 0.919 rs7093170 chr10:135402904 C/T cg20169779 chr10:135381914 SYCE1 -0.41 -5.92 -0.34 9.89e-9 Obesity-related traits; CESC cis rs9309473 0.950 rs11689588 chr2:73773691 A/G cg20560298 chr2:73613845 ALMS1 -0.55 -6.97 -0.39 2.46e-11 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04653776 chr20:32399093 CHMP4B 0.58 6.67 0.38 1.48e-10 Gut microbiome composition (summer); CESC cis rs763121 0.819 rs6001205 chr22:39100264 T/A cg06022373 chr22:39101656 GTPBP1 0.91 14.38 0.66 4.71e-35 Menopause (age at onset); CESC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg08027265 chr7:2291960 NA -0.41 -6.25 -0.36 1.65e-9 Bipolar disorder and schizophrenia; CESC cis rs2180341 0.920 rs1073932 chr6:127682009 G/T cg27446573 chr6:127587934 RNF146 1.06 15.88 0.7 2.39e-40 Breast cancer; CESC cis rs2072499 0.778 rs2842868 chr1:156196407 A/C cg25208724 chr1:156163844 SLC25A44 0.81 10.77 0.55 1.13e-22 Testicular germ cell tumor; CESC cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg10150615 chr22:24372951 LOC391322 0.49 5.87 0.34 1.32e-8 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs10170846 0.893 rs1447108 chr2:223542231 A/G cg25565276 chr2:223520875 FARSB 0.57 7.92 0.44 6.64e-14 Schizophrenia (inflammation and infection response interaction); CESC cis rs9888739 0.920 rs12920597 chr16:31304382 C/T cg15817542 chr16:31343056 ITGAM -0.5 -5.41 -0.32 1.41e-7 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22907165 chr6:13328662 TBC1D7 0.61 7.15 0.4 8.51e-12 Gut microbiome composition (summer); CESC cis rs3768617 0.510 rs3768624 chr1:183079252 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 14.14 0.66 3.44e-34 Fuchs's corneal dystrophy; CESC cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg26874164 chr19:58962979 ZNF324B 0.54 7.41 0.41 1.73e-12 Uric acid clearance; CESC cis rs8114671 0.562 rs2064454 chr20:33496169 C/T cg07148914 chr20:33460835 GGT7 0.52 6.79 0.39 7.24e-11 Height; CESC cis rs2933343 0.761 rs789225 chr3:128600229 G/A cg24203234 chr3:128598194 ACAD9 0.44 5.9 0.34 1.09e-8 IgG glycosylation; CESC trans rs657452 0.722 rs1185222 chr1:49958961 C/T cg17017335 chr3:97540665 NA 0.5 6.56 0.37 2.76e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9611565 0.592 rs5758406 chr22:42076641 A/G cg06634786 chr22:41940651 POLR3H 0.58 6.02 0.35 5.72e-9 Vitiligo; CESC trans rs11039798 0.844 rs6485820 chr11:48264711 A/G cg15704280 chr7:45808275 SEPT13 0.68 6.39 0.37 7.34e-10 Axial length; CESC cis rs7267979 1.000 rs2500448 chr20:25404027 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -15.49 -0.69 5.72e-39 Liver enzyme levels (alkaline phosphatase); CESC cis rs863345 0.625 rs11264978 chr1:158447921 T/C cg12129480 chr1:158549410 OR10X1 -0.36 -7.15 -0.4 8.56e-12 Pneumococcal bacteremia; CESC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg16325326 chr1:53192061 ZYG11B -0.7 -11.15 -0.56 6.44e-24 Monocyte count; CESC cis rs910316 0.935 rs2268620 chr14:75640403 G/A cg08847533 chr14:75593920 NEK9 -0.99 -17.84 -0.74 2.57e-47 Height; CESC cis rs7666738 0.753 rs11932536 chr4:98930105 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05366495 chr17:73915902 FBF1 0.44 6.21 0.36 2.03e-9 Fibrinogen levels; CESC cis rs921968 0.565 rs13408305 chr2:219628183 G/A cg02176678 chr2:219576539 TTLL4 -0.44 -7.73 -0.43 2.21e-13 Mean corpuscular hemoglobin concentration; CESC cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg24209194 chr3:40518798 ZNF619 0.53 7.08 0.4 1.31e-11 Renal cell carcinoma; CESC cis rs7927771 0.524 rs10742817 chr11:47689343 A/G cg20307385 chr11:47447363 PSMC3 -0.64 -9.1 -0.49 2.24e-17 Subjective well-being; CESC cis rs6087990 0.814 rs2424895 chr20:31335978 C/T cg13636640 chr20:31349939 DNMT3B -0.79 -13.11 -0.63 1.33e-30 Ulcerative colitis; CESC cis rs9486715 0.867 rs11152924 chr6:96877383 A/G cg18709589 chr6:96969512 KIAA0776 0.45 6.46 0.37 5.05e-10 Headache; CESC cis rs425277 1.000 rs262647 chr1:2095699 C/T cg16545954 chr1:2118288 C1orf86 0.33 5.64 0.33 4.4e-8 Height; CESC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg26343298 chr8:95960752 TP53INP1 0.36 5.87 0.34 1.3e-8 Type 2 diabetes; CESC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg00339695 chr16:24857497 SLC5A11 0.53 6.61 0.38 2.07e-10 Intelligence (multi-trait analysis); CESC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg07167872 chr1:205819463 PM20D1 0.75 12.28 0.6 9.7e-28 Menarche (age at onset); CESC cis rs9486715 0.867 rs4438964 chr6:96917563 T/G cg18709589 chr6:96969512 KIAA0776 0.47 6.66 0.38 1.59e-10 Headache; CESC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg11644478 chr21:40555479 PSMG1 1.03 16.93 0.72 4.47e-44 Cognitive function; CESC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.67 -0.38 1.5e-10 Bipolar disorder; CESC cis rs2569991 0.636 rs361223 chr3:12922526 T/C cg22481960 chr3:13008800 IQSEC1 -0.57 -6.88 -0.39 4.36e-11 Periodontitis (DPAL); CESC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg26343298 chr8:95960752 TP53INP1 0.37 6.06 0.35 4.58e-9 Type 2 diabetes; CESC cis rs1707322 0.752 rs28812624 chr1:46203736 T/A cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6723226 0.552 rs62136336 chr2:32804106 G/A cg02381751 chr2:32503542 YIPF4 0.81 10.88 0.56 4.75e-23 Intelligence (multi-trait analysis); CESC cis rs7520050 0.966 rs7550746 chr1:46351719 T/A cg03146154 chr1:46216737 IPP -0.49 -6.42 -0.37 6.3e-10 Red blood cell count;Reticulocyte count; CESC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg02475777 chr4:1388615 CRIPAK -0.46 -5.95 -0.34 8.25e-9 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25177113 chr1:955463 AGRN -0.46 -6.13 -0.35 3.1e-9 Fibrinogen levels; CESC cis rs9457247 0.602 rs13204839 chr6:167471119 G/A cg23791538 chr6:167370224 RNASET2 -0.52 -6.9 -0.39 3.81e-11 Crohn's disease; CESC cis rs6546537 0.915 rs4852866 chr2:69829916 T/C cg10773587 chr2:69614142 GFPT1 -0.43 -5.17 -0.3 4.58e-7 Serum thyroid-stimulating hormone levels; CESC trans rs17685 0.712 rs2158867 chr7:75815141 C/A cg19862616 chr7:65841803 NCRNA00174 0.82 11.63 0.58 1.6e-25 Coffee consumption;Coffee consumption (cups per day); CESC cis rs1178968 0.818 rs4717086 chr7:72777049 A/G cg25889504 chr7:72793014 NA 0.47 5.03 0.3 8.91e-7 Triglyceride levels; CESC cis rs4076764 0.958 rs11584957 chr1:163392937 C/T cg24596788 chr1:163392923 NA -0.52 -7.52 -0.42 8.31e-13 Motion sickness; CESC cis rs965469 1.000 rs2236122 chr20:3305240 C/T cg25506879 chr20:3388711 C20orf194 -0.53 -5.59 -0.32 5.77e-8 IFN-related cytopenia; CESC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg02018176 chr4:1364513 KIAA1530 0.41 5.82 0.34 1.66e-8 Longevity; CESC cis rs9486719 1.000 rs13210597 chr6:96969694 C/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.83 -0.34 1.64e-8 Migraine;Coronary artery disease; CESC trans rs7615952 0.688 rs17334074 chr3:125540460 A/G cg07211511 chr3:129823064 LOC729375 0.79 8.99 0.48 4.67e-17 Blood pressure (smoking interaction); CESC cis rs763121 0.853 rs5757166 chr22:38995385 G/T cg06022373 chr22:39101656 GTPBP1 0.95 17.17 0.73 6.29e-45 Menopause (age at onset); CESC cis rs9811920 0.809 rs13059754 chr3:99678490 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -7.64 -0.42 4.04e-13 Axial length; CESC cis rs2904967 0.562 rs239255 chr11:64987128 G/A cg23743554 chr11:65321226 LTBP3 -0.4 -5.21 -0.3 3.82e-7 Mean corpuscular volume; CESC cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 0.966 rs2302393 chr4:17654341 G/A cg02297831 chr4:17616191 MED28 0.57 7.29 0.41 3.57e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs950776 0.667 rs57728226 chr15:78929350 G/C cg06917634 chr15:78832804 PSMA4 0.56 6.65 0.38 1.62e-10 Sudden cardiac arrest; CESC cis rs9291683 1.000 rs9291683 chr4:10324160 C/T cg00071950 chr4:10020882 SLC2A9 0.52 7.81 0.43 1.36e-13 Bone mineral density; CESC cis rs314370 0.818 rs12705091 chr7:100472380 C/T cg10426581 chr7:100472382 SRRT 0.82 8.27 0.45 6.6e-15 Resting heart rate; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19101460 chr15:59949499 GTF2A2 -0.49 -6.86 -0.39 4.9e-11 Asthma; CESC cis rs892961 0.932 rs7216909 chr17:75405234 A/G cg05865280 chr17:75406074 SEPT9 0.66 13.17 0.63 8e-31 Airflow obstruction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13957827 chr4:164415471 C4orf43 0.6 6.32 0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs10887741 0.646 rs10218939 chr10:89436853 A/G cg13926569 chr10:89418898 PAPSS2 0.47 7.15 0.4 8.25e-12 Exercise (leisure time); CESC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg01570182 chr17:44337453 NA -0.63 -8.48 -0.46 1.63e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18449345 chr7:30068347 PLEKHA8 -0.44 -6.49 -0.37 4.32e-10 Ulcerative colitis; CESC cis rs763014 0.931 rs7192508 chr16:630367 C/T cg00908189 chr16:619842 PIGQ 0.67 9.39 0.5 2.81e-18 Height; CESC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.22 -0.36 1.96e-9 Parkinson's disease; CESC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.65 0.64 1.8e-32 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25618672 chr7:65939712 NA -0.66 -7.25 -0.41 4.49e-12 Gut microbiome composition (summer); CESC trans rs17508449 0.779 rs78703286 chr1:114148115 A/G cg23028848 chr11:57092561 TNKS1BP1 -0.77 -6.14 -0.35 2.98e-9 Leprosy; CESC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.2 0.53 7.94e-21 Prudent dietary pattern; CESC cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg26408565 chr15:76604113 ETFA -0.42 -6.08 -0.35 4.19e-9 Blood metabolite levels; CESC cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg19052272 chr2:3704530 ALLC -0.47 -5.84 -0.34 1.51e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs4535700 0.501 rs9642405 chr7:55978166 C/T cg13278478 chr7:56160911 PHKG1 0.33 5.03 0.3 8.9e-7 Macular telangiectasia type 2; CESC cis rs367943 0.698 rs13167361 chr5:112961789 C/G cg12552261 chr5:112820674 MCC 0.44 5.66 0.33 3.85e-8 Type 2 diabetes; CESC cis rs4132509 0.744 rs10927065 chr1:243914611 G/T cg21452805 chr1:244014465 NA 0.56 6.82 0.39 6.3e-11 RR interval (heart rate); CESC cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg10494973 chr17:80897199 TBCD 0.52 6.55 0.37 3.06e-10 Breast cancer; CESC trans rs11039798 0.699 rs7120775 chr11:48266736 C/G cg15704280 chr7:45808275 SEPT13 0.68 6.39 0.37 7.34e-10 Axial length; CESC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg23982607 chr1:1823379 GNB1 -0.78 -12.68 -0.61 4.08e-29 Body mass index; CESC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg27266027 chr21:40555129 PSMG1 0.45 5.29 0.31 2.59e-7 Cognitive function; CESC cis rs78456975 1.000 rs6720874 chr2:1580504 A/G cg26248373 chr2:1572462 NA -0.51 -5.15 -0.3 4.99e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4561483 0.801 rs8061189 chr16:11951749 C/G cg08843971 chr16:11963173 GSPT1 0.55 7.9 0.44 7.57e-14 Testicular germ cell tumor; CESC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg21770322 chr7:97807741 LMTK2 0.54 8.17 0.45 1.26e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg11764359 chr7:65958608 NA -0.81 -9.98 -0.52 4.19e-20 Aortic root size; CESC cis rs8060686 0.858 rs11553287 chr16:67905407 A/G cg26727032 chr16:67993705 SLC12A4 -0.66 -9.7 -0.51 3.07e-19 HDL cholesterol;Metabolic syndrome; CESC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg23161317 chr6:28129485 ZNF389 0.54 6.8 0.39 6.81e-11 Depression; CESC cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg17211192 chr8:82754475 SNX16 -0.71 -8.32 -0.45 4.8e-15 Diastolic blood pressure; CESC cis rs13392177 0.647 rs6718220 chr2:219066518 T/C cg00012203 chr2:219082015 ARPC2 -0.68 -8.55 -0.46 1.02e-15 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs6696846 0.749 rs6692170 chr1:205074019 G/A cg00857998 chr1:205179979 DSTYK 0.5 6.79 0.39 7.13e-11 Red blood cell count; CESC cis rs9303401 0.659 rs1864754 chr17:56688789 G/T cg02118635 chr17:56770003 RAD51C;TEX14 -1.02 -12.94 -0.62 5.18e-30 Cognitive test performance; CESC cis rs10832963 1.000 rs7943121 chr11:18656062 G/C cg20219074 chr11:18656078 SPTY2D1 0.8 11.7 0.58 9.24e-26 Breast cancer; CESC cis rs7666738 0.716 rs114187620 chr4:98819534 T/A cg17366294 chr4:99064904 C4orf37 0.55 7.5 0.42 9.71e-13 Colonoscopy-negative controls vs population controls; CESC cis rs7680126 0.596 rs4697714 chr4:10143786 A/T cg00071950 chr4:10020882 SLC2A9 -0.51 -6.12 -0.35 3.32e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs5760092 0.618 rs4461358 chr22:24260106 T/C cg10150615 chr22:24372951 LOC391322 0.48 5.82 0.34 1.66e-8 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs7818688 0.697 rs11779698 chr8:95979764 C/G cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14047321 chr14:62523576 SYT16 -0.63 -7.46 -0.42 1.23e-12 Gut microbiome composition (summer); CESC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg19592336 chr6:28129416 ZNF389 0.44 6.38 0.36 7.89e-10 Parkinson's disease; CESC trans rs7246760 1.000 rs1592997 chr19:9900983 G/A cg02900749 chr2:68251473 NA -0.78 -7.1 -0.4 1.18e-11 Pursuit maintenance gain; CESC cis rs7212590 0.618 rs7217337 chr17:58023417 C/T cg20303301 chr17:57937339 TUBD1 -0.55 -5.57 -0.32 6.25e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs8060686 0.516 rs9938020 chr16:68251784 C/G cg26727032 chr16:67993705 SLC12A4 -0.51 -6.82 -0.39 6.18e-11 HDL cholesterol;Metabolic syndrome; CESC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.73 -0.38 1.06e-10 Electroencephalogram traits; CESC cis rs4919694 1.000 rs79254677 chr10:104691567 A/G cg04362960 chr10:104952993 NT5C2 0.79 6.69 0.38 1.35e-10 Arsenic metabolism; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg19041146 chr11:118401536 TMEM25;TTC36 0.46 6.37 0.36 8.47e-10 Bronchopulmonary dysplasia; CESC cis rs4268898 0.722 rs7564420 chr2:24414002 C/T cg06627628 chr2:24431161 ITSN2 -0.58 -7.42 -0.41 1.6e-12 Asthma; CESC cis rs12188164 0.561 rs2721010 chr5:456915 A/G cg16584290 chr5:462447 EXOC3 0.47 7.1 0.4 1.12e-11 Cystic fibrosis severity; CESC cis rs12478296 0.901 rs67423532 chr2:243004719 A/G cg06360820 chr2:242988706 NA -0.73 -9.07 -0.49 2.7e-17 Obesity-related traits; CESC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg04944784 chr2:26401820 FAM59B 0.96 10.55 0.54 5.79e-22 Gut microbiome composition (summer); CESC trans rs9388451 0.591 rs1268792 chr6:126042124 G/A cg05039488 chr6:79577232 IRAK1BP1 0.49 6.27 0.36 1.47e-9 Brugada syndrome; CESC cis rs72781680 0.752 rs55806536 chr2:23912697 A/G cg20701182 chr2:24300061 SF3B14 0.8 6.94 0.39 3.03e-11 Lymphocyte counts; CESC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.19 0.3 4.29e-7 Electroencephalogram traits; CESC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg22903657 chr4:1355424 KIAA1530 -0.37 -5.13 -0.3 5.71e-7 Obesity-related traits; CESC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs3733585 0.648 rs7376155 chr4:9952588 C/T cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7165102 1.000 rs11632310 chr15:65882326 G/C cg11441148 chr15:65824328 PTPLAD1 0.32 5.52 0.32 8.09e-8 Mean corpuscular hemoglobin; CESC cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg19077165 chr18:44547161 KATNAL2 -0.61 -9.19 -0.49 1.2e-17 Personality dimensions; CESC trans rs2018683 0.899 rs10479817 chr7:28978148 A/C cg19402173 chr7:128379420 CALU -0.54 -7.07 -0.4 1.4e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg19592336 chr6:28129416 ZNF389 0.59 7.78 0.43 1.63e-13 Depression; CESC cis rs1801251 0.752 rs2592126 chr2:233751377 A/G cg25237894 chr2:233734115 C2orf82 -0.48 -8.44 -0.46 2.07e-15 Coronary artery disease; CESC cis rs644799 1.000 rs544119 chr11:95538624 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2235544 0.579 rs1537322 chr1:54482306 G/T cg25741118 chr1:54482237 LDLRAD1 -0.22 -5.7 -0.33 3.23e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs57244997 0.725 rs7746052 chr6:162436267 G/A cg17173639 chr6:162384350 PARK2 -0.5 -5.86 -0.34 1.4e-8 Mosquito bite size; CESC cis rs10779751 0.734 rs1148485 chr1:11148759 G/A cg08854313 chr1:11322531 MTOR 0.73 8.35 0.46 3.81e-15 Body mass index; CESC cis rs7178909 0.902 rs28372736 chr15:90437858 T/C cg19708238 chr15:90437601 AP3S2 0.43 6.19 0.36 2.25e-9 Common traits (Other); CESC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.37 0.31 1.72e-7 Parkinson's disease; CESC cis rs12477438 0.798 rs1580068 chr2:99649969 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs1372520 0.577 rs2737021 chr4:90739992 T/A cg15133208 chr4:90757351 SNCA -0.4 -5.3 -0.31 2.43e-7 Neuroticism; CESC cis rs12325245 0.536 rs8058781 chr16:58653838 G/A cg05725404 chr16:58534157 NDRG4 -0.63 -5.32 -0.31 2.21e-7 Schizophrenia; CESC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg17724175 chr1:150552817 MCL1 0.38 5.9 0.34 1.11e-8 Melanoma; CESC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg21906852 chr1:75198582 TYW3;CRYZ 0.42 5.3 0.31 2.48e-7 Resistin levels; CESC cis rs5758659 0.819 rs134871 chr22:42652716 A/G cg15557168 chr22:42548783 NA -0.36 -5.66 -0.33 3.92e-8 Cognitive function; CESC cis rs67478160 0.643 rs12880821 chr14:104276049 C/T cg08213375 chr14:104286397 PPP1R13B 0.52 9.81 0.52 1.42e-19 Schizophrenia; CESC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg27266027 chr21:40555129 PSMG1 0.44 5.25 0.31 3.16e-7 Cognitive function; CESC cis rs13191362 0.872 rs67712738 chr6:163245768 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.63 6.16 0.35 2.66e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs67478160 0.625 rs7141473 chr14:104316055 A/C cg01849466 chr14:104193079 ZFYVE21 0.51 6.92 0.39 3.31e-11 Schizophrenia; CESC cis rs7927771 0.965 rs3817335 chr11:47643891 T/A cg18512352 chr11:47633146 NA -0.6 -9.5 -0.5 1.32e-18 Subjective well-being; CESC trans rs7837860 0.541 rs13248408 chr8:89285609 C/T cg04391754 chr17:18022714 MYO15A 0.52 6.12 0.35 3.41e-9 Autism spectrum disorder or schizophrenia; CESC cis rs72781680 0.898 rs72786278 chr2:24063243 C/T cg08917208 chr2:24149416 ATAD2B 0.93 8.48 0.46 1.57e-15 Lymphocyte counts; CESC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg04546413 chr19:29218101 NA 0.56 7.91 0.44 6.84e-14 Methadone dose in opioid dependence; CESC cis rs6088813 1.000 rs6142374 chr20:33985568 C/T cg14752227 chr20:34000481 UQCC -0.4 -5.08 -0.3 7.17e-7 Height; CESC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg16325326 chr1:53192061 ZYG11B 0.73 11.05 0.56 1.33e-23 Monocyte count; CESC trans rs7746199 0.736 rs34573979 chr6:27480526 C/T cg01620082 chr3:125678407 NA -0.78 -6.65 -0.38 1.71e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs2797160 0.651 rs1268093 chr6:126029235 C/T cg05901451 chr6:126070800 HEY2 0.45 6.61 0.38 2.07e-10 Endometrial cancer; CESC cis rs6032067 0.929 rs17424668 chr20:43809647 C/T cg10761708 chr20:43804764 PI3 -0.53 -6.58 -0.37 2.53e-10 Blood protein levels; CESC cis rs7429990 0.965 rs4858881 chr3:48123796 C/G cg11946769 chr3:48343235 NME6 -0.44 -5.47 -0.32 1.02e-7 Educational attainment (years of education); CESC cis rs2295499 0.933 rs9683585 chr4:2702804 C/G cg08330972 chr4:2403930 ZFYVE28 -0.37 -6.15 -0.35 2.85e-9 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs992157 0.767 rs2382822 chr2:219173327 T/C cg00012203 chr2:219082015 ARPC2 -0.72 -9.33 -0.5 4.35e-18 Colorectal cancer; CESC cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg00409905 chr10:38381863 ZNF37A -0.44 -5.87 -0.34 1.32e-8 Extrinsic epigenetic age acceleration; CESC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg07701084 chr6:150067640 NUP43 0.47 6.62 0.38 1.97e-10 Lung cancer; CESC cis rs11098499 0.954 rs10014845 chr4:120301077 T/G cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs4076764 0.535 rs4409627 chr1:163382050 A/G cg24596788 chr1:163392923 NA 0.33 5.27 0.31 2.83e-7 Motion sickness; CESC cis rs11098499 0.863 rs1552095 chr4:120460306 A/G cg09307838 chr4:120376055 NA 0.94 12.51 0.61 1.52e-28 Corneal astigmatism; CESC cis rs68170813 0.559 rs7981 chr7:106843133 G/C cg02696742 chr7:106810147 HBP1 -0.53 -5.07 -0.3 7.63e-7 Coronary artery disease; CESC cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg06484146 chr7:12443880 VWDE -0.75 -10.31 -0.54 3.55e-21 Coronary artery disease; CESC cis rs8028182 0.525 rs9920028 chr15:75927717 G/A cg20655648 chr15:75932815 IMP3 0.52 6.55 0.37 3.01e-10 Sudden cardiac arrest; CESC cis rs34779708 0.931 rs17583009 chr10:35320915 T/C cg04310649 chr10:35416472 CREM -0.48 -5.8 -0.34 1.85e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs11098499 0.863 rs11736416 chr4:120431661 C/T cg24375607 chr4:120327624 NA 0.44 5.27 0.31 2.85e-7 Corneal astigmatism; CESC cis rs9457247 0.935 rs9348211 chr6:167375173 G/C cg23791538 chr6:167370224 RNASET2 0.58 8.26 0.45 7.1e-15 Crohn's disease; CESC cis rs751728 0.544 rs2281820 chr6:33768897 A/G cg25922239 chr6:33757077 LEMD2 0.44 5.83 0.34 1.57e-8 Crohn's disease; CESC trans rs3749237 0.964 rs35210174 chr3:49812606 C/T cg21659725 chr3:3221576 CRBN 0.53 6.23 0.36 1.84e-9 Resting heart rate; CESC cis rs3857067 0.933 rs10023582 chr4:95035811 G/A cg11021082 chr4:95130006 SMARCAD1 -0.52 -7.81 -0.43 1.33e-13 QT interval; CESC cis rs889312 0.500 rs33328 chr5:56143419 T/C cg14703610 chr5:56206110 C5orf35 0.48 6.31 0.36 1.19e-9 Breast cancer;Breast cancer (early onset); CESC cis rs1577917 0.771 rs7452605 chr6:86240951 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.55 7.67 0.43 3.2e-13 Response to antipsychotic treatment; CESC cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg16240275 chr20:61666158 NCRNA00029 0.5 8.93 0.48 7.38e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs1348850 0.597 rs13014512 chr2:178470851 T/A cg23306229 chr2:178417860 TTC30B 0.6 6.07 0.35 4.33e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10883723 0.668 rs12414407 chr10:104387019 A/G cg22532475 chr10:104410764 TRIM8 0.34 5.82 0.34 1.7e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs6460942 0.659 rs28366613 chr7:12512167 C/T cg06484146 chr7:12443880 VWDE -0.67 -7.12 -0.4 1e-11 Coronary artery disease; CESC cis rs9308433 0.529 rs4655246 chr1:214502898 G/C cg06198575 chr1:214491504 SMYD2 0.47 5.49 0.32 9.23e-8 IgG glycosylation; CESC cis rs367615 0.704 rs7704824 chr5:108850278 A/G cg17395555 chr5:108820864 NA 0.52 8.79 0.48 1.96e-16 Colorectal cancer (SNP x SNP interaction); CESC trans rs561341 1.000 rs113676348 chr17:30244327 A/G cg20587970 chr11:113659929 NA -1.11 -13.7 -0.64 1.19e-32 Hip circumference adjusted for BMI; CESC cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.35 5.65 0.33 4.04e-8 Personality dimensions; CESC cis rs9467773 1.000 rs9295695 chr6:26528250 C/T cg11502198 chr6:26597334 ABT1 -0.37 -5.3 -0.31 2.48e-7 Intelligence (multi-trait analysis); CESC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg19346786 chr7:2764209 NA -0.49 -7.07 -0.4 1.35e-11 Height; CESC cis rs1163251 0.756 rs539799 chr1:120208472 C/T cg19096424 chr1:120255104 PHGDH 0.43 5.59 0.32 5.58e-8 Blood metabolite levels; CESC cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg24578937 chr1:2090814 PRKCZ 0.33 5.82 0.34 1.66e-8 Height; CESC cis rs1018836 0.923 rs13277387 chr8:91633713 C/G cg16814680 chr8:91681699 NA -0.72 -10.41 -0.54 1.68e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18965055 chr4:174291932 SAP30 -0.42 -6.87 -0.39 4.68e-11 Gambling; CESC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg18099408 chr3:52552593 STAB1 -0.32 -5.43 -0.32 1.28e-7 Electroencephalogram traits; CESC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg10691866 chr7:65817282 TPST1 -0.33 -5.41 -0.32 1.44e-7 Aortic root size; CESC trans rs116095464 0.510 rs10057501 chr5:239545 T/C cg00938859 chr5:1591904 SDHAP3 0.64 7.02 0.4 1.84e-11 Breast cancer; CESC cis rs2295499 0.643 rs2298965 chr4:2699655 C/G cg27239842 chr4:2403781 ZFYVE28 0.3 5.08 0.3 7.11e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs12122100 0.526 rs12122534 chr1:146504399 A/G cg02487331 chr1:146550467 NA 0.37 5.69 0.33 3.44e-8 HIV-1 control; CESC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg10295955 chr4:187884368 NA -1.08 -22.82 -0.81 1.67e-64 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24905370 chr5:74063138 NSA2;GFM2 -0.61 -7.13 -0.4 9.35e-12 Gut microbiome composition (summer); CESC cis rs9287719 0.753 rs2018512 chr2:10759279 T/G cg02196655 chr2:10830764 NOL10 -0.36 -5.59 -0.32 5.58e-8 Prostate cancer; CESC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg04025307 chr7:1156635 C7orf50 0.47 5.75 0.33 2.51e-8 Bronchopulmonary dysplasia; CESC cis rs35110281 0.591 rs86139 chr21:44932802 G/A cg01579765 chr21:45077557 HSF2BP -0.49 -8.29 -0.45 5.59e-15 Mean corpuscular volume; CESC cis rs7659604 0.605 rs2071486 chr4:122740162 C/T cg06713675 chr4:122721982 EXOSC9 -0.43 -6.09 -0.35 4.03e-9 Type 2 diabetes; CESC cis rs5753618 0.539 rs2106294 chr22:31645759 C/T cg02404636 chr22:31891804 SFI1 -0.4 -5.27 -0.31 2.87e-7 Colorectal cancer; CESC cis rs11168618 0.567 rs7314569 chr12:48816981 G/T cg24011408 chr12:48396354 COL2A1 0.36 5.69 0.33 3.33e-8 Adiponectin levels; CESC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg18876405 chr7:65276391 NA -0.51 -6.96 -0.39 2.72e-11 Aortic root size; CESC cis rs9291683 0.507 rs3775940 chr4:10025163 A/T cg11266682 chr4:10021025 SLC2A9 0.66 13.19 0.63 7.23e-31 Bone mineral density; CESC trans rs7690543 0.681 rs6552071 chr4:68002397 C/T cg05505961 chr17:66375071 ARSG -0.52 -6.09 -0.35 3.87e-9 Glucose homeostasis traits; CESC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg22920501 chr2:26401640 FAM59B 0.89 9.91 0.52 6.61e-20 Gut microbiome composition (summer); CESC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg16145915 chr7:1198662 ZFAND2A -0.49 -7.0 -0.4 2.08e-11 Longevity;Endometriosis; CESC cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg22467129 chr15:76604101 ETFA -0.35 -5.25 -0.31 3.16e-7 Blood metabolite levels; CESC cis rs4664304 0.789 rs2063439 chr2:160800101 C/A cg03641300 chr2:160917029 PLA2R1 -0.41 -5.46 -0.32 1.1e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs7264396 0.790 rs2425083 chr20:34300456 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.48 0.42 1.11e-12 Total cholesterol levels; CESC cis rs1005277 0.579 rs2800485 chr10:38542588 G/A cg00409905 chr10:38381863 ZNF37A -0.5 -6.7 -0.38 1.27e-10 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08740862 chr11:62314417 AHNAK 0.6 6.76 0.38 8.67e-11 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17817067 chr5:14713179 ANKH 0.45 6.15 0.35 2.81e-9 Fibrinogen levels; CESC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg20644253 chr19:19431407 KIAA0892;SF4 0.6 7.47 0.42 1.2e-12 Tonsillectomy; CESC cis rs7089973 0.604 rs1359079 chr10:116582502 A/G cg03647239 chr10:116582469 FAM160B1 0.42 5.13 0.3 5.48e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06629088 chr16:87984646 BANP 0.56 6.48 0.37 4.32e-10 Gut microbiome composition (summer); CESC cis rs1707322 0.963 rs4508055 chr1:46257731 A/T cg06784218 chr1:46089804 CCDC17 0.37 6.37 0.36 8.49e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7927771 0.929 rs12787646 chr11:47669665 T/C cg05585544 chr11:47624801 NA -0.47 -7.36 -0.41 2.36e-12 Subjective well-being; CESC cis rs4969178 0.965 rs12451715 chr17:76397334 A/C cg05887092 chr17:76393375 PGS1 0.58 9.22 0.49 9.9e-18 HDL cholesterol levels; CESC cis rs4843747 0.671 rs28679286 chr16:88106307 C/T cg06915872 chr16:87998081 BANP 0.44 5.24 0.31 3.36e-7 Menopause (age at onset); CESC trans rs2235573 0.527 rs139886 chr22:38371328 C/T cg19894588 chr14:64061835 NA 0.58 7.64 0.42 3.94e-13 Glioblastoma;Glioma; CESC cis rs10911232 0.507 rs10797832 chr1:183044034 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 13.23 0.63 5.11e-31 Hypertriglyceridemia; CESC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg05861140 chr6:150128134 PCMT1 -0.35 -5.07 -0.3 7.45e-7 Lung cancer; CESC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.13 0.4 9.54e-12 Height; CESC cis rs1670533 1.000 rs6599278 chr4:1058798 C/T cg04106633 chr4:1044584 NA 0.42 5.43 0.32 1.3e-7 Recombination rate (females); CESC cis rs10751667 0.666 rs11246357 chr11:963980 A/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.36 -0.31 1.82e-7 Alzheimer's disease (late onset); CESC cis rs1510510 0.932 rs2136772 chr2:239492898 C/T cg14780600 chr2:240281345 HDAC4 0.43 5.26 0.31 2.93e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09311964 chr17:40831349 NA -0.58 -6.48 -0.37 4.41e-10 Gut microbiome composition (summer); CESC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg21269045 chr12:125625041 AACS -0.38 -5.88 -0.34 1.25e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.85e-16 Colonoscopy-negative controls vs population controls; CESC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg00339695 chr16:24857497 SLC5A11 0.54 6.74 0.38 9.94e-11 Intelligence (multi-trait analysis); CESC cis rs6545883 0.929 rs2600663 chr2:61540687 A/G cg15711740 chr2:61764176 XPO1 0.43 5.39 0.31 1.59e-7 Tuberculosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03690763 chr11:133734501 NA -0.45 -6.1 -0.35 3.82e-9 Gut microbiome composition (summer); CESC cis rs722599 0.599 rs8003660 chr14:75227098 T/C cg11812906 chr14:75593930 NEK9 0.45 5.49 0.32 9.6e-8 IgG glycosylation; CESC cis rs2019216 0.542 rs1850564 chr17:21911794 T/C cg22648282 chr17:21454238 C17orf51 -0.43 -5.61 -0.33 5.05e-8 Pelvic organ prolapse; CESC cis rs13106227 0.550 rs11723732 chr4:77370557 A/G cg20311846 chr4:77356250 SHROOM3 -0.31 -5.8 -0.34 1.87e-8 Eosinophilic esophagitis (pediatric); CESC cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.29 0.45 5.87e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs208520 0.690 rs10455594 chr6:66737894 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.26 0.6 1.09e-27 Exhaled nitric oxide output; CESC cis rs941408 0.515 rs12610096 chr19:2778129 C/T cg06609049 chr19:2785107 THOP1 0.96 14.82 0.67 1.28e-36 Total cholesterol levels; CESC cis rs2832077 0.527 rs2776210 chr21:30268558 A/G cg08807101 chr21:30365312 RNF160 0.66 8.37 0.46 3.26e-15 Cognitive test performance; CESC cis rs1670533 1.000 rs13107058 chr4:1054379 G/A cg04106633 chr4:1044584 NA 0.41 5.23 0.31 3.36e-7 Recombination rate (females); CESC cis rs7937682 0.924 rs499750 chr11:111513645 T/G cg09085632 chr11:111637200 PPP2R1B -0.99 -16.07 -0.7 5.11e-41 Primary sclerosing cholangitis; CESC cis rs9837602 0.576 rs506186 chr3:99442753 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.44 -5.83 -0.34 1.58e-8 Breast cancer; CESC cis rs8180040 0.620 rs6768722 chr3:47079112 G/A cg27129171 chr3:47204927 SETD2 0.66 9.82 0.52 1.32e-19 Colorectal cancer; CESC trans rs9858542 0.953 rs4625 chr3:49572140 A/G cg21659725 chr3:3221576 CRBN -0.52 -6.48 -0.37 4.43e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs400736 0.665 rs225104 chr1:8119903 A/G cg25007680 chr1:8021821 PARK7 0.61 8.5 0.46 1.44e-15 Response to antidepressants and depression; CESC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg20203395 chr5:56204925 C5orf35 0.43 5.12 0.3 5.82e-7 Initial pursuit acceleration; CESC cis rs3806843 0.966 rs2563267 chr5:140136913 C/T cg26395211 chr5:140044315 WDR55 0.44 5.59 0.32 5.7e-8 Depressive symptoms (multi-trait analysis); CESC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg00339695 chr16:24857497 SLC5A11 0.51 6.68 0.38 1.42e-10 Intelligence (multi-trait analysis); CESC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.88e-8 Lung cancer; CESC cis rs698833 0.819 rs2340809 chr2:44536249 A/G cg04920474 chr2:44395004 PPM1B 0.37 5.19 0.3 4.24e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs12765878 1.000 rs2273698 chr10:105649158 G/A cg11005552 chr10:105648138 OBFC1 0.35 5.06 0.3 7.92e-7 Coronary artery disease; CESC cis rs2276314 0.857 rs59649576 chr18:33616075 G/T cg05985134 chr18:33552581 C18orf21 0.63 7.59 0.42 5.58e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs8060686 0.641 rs55682260 chr16:68057880 G/A cg26727032 chr16:67993705 SLC12A4 -0.54 -6.13 -0.35 3.24e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg11859384 chr17:80120422 CCDC57 0.4 5.5 0.32 8.88e-8 Life satisfaction; CESC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg17221315 chr6:27791827 HIST1H4J 0.44 5.78 0.33 2.06e-8 Cardiac Troponin-T levels; CESC cis rs1832871 0.672 rs11751081 chr6:158761505 G/A cg07165851 chr6:158734300 TULP4 0.58 6.2 0.36 2.1e-9 Height; CESC cis rs7666738 0.791 rs34152299 chr4:98929862 G/C cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg23161317 chr6:28129485 ZNF389 0.49 6.18 0.35 2.42e-9 Parkinson's disease; CESC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg16405210 chr4:1374714 KIAA1530 0.42 5.04 0.3 8.45e-7 Obesity-related traits; CESC cis rs2439831 0.867 rs3809481 chr15:43662829 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.85 11.31 0.57 1.8e-24 Lung cancer in ever smokers; CESC cis rs977987 0.902 rs34539062 chr16:75493279 C/A cg03315344 chr16:75512273 CHST6 0.54 7.9 0.44 7.62e-14 Dupuytren's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07697635 chr5:77656183 SCAMP1 -0.49 -6.47 -0.37 4.81e-10 Fibrinogen levels; CESC cis rs67311347 1.000 rs9822644 chr3:40426609 G/A cg09455208 chr3:40491958 NA 0.49 7.91 0.44 6.79e-14 Renal cell carcinoma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15734422 chr10:121356865 TIAL1 -0.47 -6.52 -0.37 3.57e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08740477 chr5:108084642 FER 0.57 6.31 0.36 1.18e-9 Gut microbiome composition (summer); CESC trans rs11039798 1.000 rs7102865 chr11:48458361 A/C cg15704280 chr7:45808275 SEPT13 0.69 6.58 0.37 2.56e-10 Axial length; CESC cis rs1609391 0.561 rs9289523 chr3:136635589 C/G cg15507776 chr3:136538369 TMEM22 0.83 12.21 0.6 1.69e-27 Neuroticism; CESC cis rs7851660 0.874 rs1443436 chr9:100631298 T/A cg13688889 chr9:100608707 NA -0.6 -8.55 -0.47 9.84e-16 Strep throat; CESC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg23758822 chr17:41437982 NA 1.03 15.5 0.69 5.3e-39 Menopause (age at onset); CESC cis rs116095464 1.000 rs6555160 chr5:311669 A/G cg10591111 chr5:226296 SDHA 0.55 5.15 0.3 5.17e-7 Breast cancer; CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg18337363 chr3:52569053 NT5DC2 0.33 6.47 0.37 4.7e-10 Bipolar disorder; CESC cis rs10078 0.571 rs2561664 chr5:459793 T/C cg08916839 chr5:415575 AHRR 0.58 6.73 0.38 1.06e-10 Fat distribution (HIV); CESC cis rs7084402 0.935 rs10763558 chr10:60341934 A/C cg07615347 chr10:60278583 BICC1 -0.55 -8.32 -0.46 4.76e-15 Refractive error; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22614265 chr7:100425456 EPHB4 0.5 6.43 0.37 5.93e-10 Gut microbiota (bacterial taxa); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07798137 chr1:17332259 ATP13A2 0.44 6.25 0.36 1.59e-9 Fibrinogen levels; CESC cis rs11249608 0.789 rs7704963 chr5:178436854 A/G cg10208897 chr5:178548229 ADAMTS2 0.35 5.22 0.31 3.63e-7 Pubertal anthropometrics; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06143244 chr16:22435202 RRN3P3 -0.64 -7.13 -0.4 9.31e-12 Gut microbiome composition (summer); CESC cis rs7267979 1.000 rs6050555 chr20:25328543 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -17.26 -0.73 3.06e-45 Liver enzyme levels (alkaline phosphatase); CESC cis rs9915657 0.870 rs11077595 chr17:70130030 C/T cg09344028 chr17:70110421 NA 0.35 6.17 0.35 2.53e-9 Thyroid hormone levels; CESC trans rs931812 0.825 rs34153562 chr8:101893441 T/C cg20993868 chr7:22813445 NA 0.55 7.52 0.42 8.52e-13 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg11764359 chr7:65958608 NA 0.96 15.25 0.68 3.95e-38 Aortic root size; CESC cis rs3768617 0.510 rs12091137 chr1:183075732 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 14.06 0.65 6.34e-34 Fuchs's corneal dystrophy; CESC cis rs3126085 1.000 rs3126097 chr1:152311026 G/A cg03465714 chr1:152285911 FLG 0.41 5.2 0.3 4.06e-7 Atopic dermatitis; CESC cis rs7264396 0.635 rs6060703 chr20:34529906 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.57 6.93 0.39 3.24e-11 Total cholesterol levels; CESC trans rs2727020 0.734 rs1164663 chr11:49294723 A/T cg15704280 chr7:45808275 SEPT13 0.79 10.49 0.54 9.39e-22 Coronary artery disease; CESC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.42 0.32 1.34e-7 Personality dimensions; CESC cis rs2979489 0.945 rs2979472 chr8:30291704 G/C cg26383811 chr8:30366931 RBPMS 0.83 9.67 0.51 3.92e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg18404041 chr3:52824283 ITIH1 -0.44 -7.04 -0.4 1.65e-11 Bipolar disorder; CESC cis rs6963495 0.818 rs117907809 chr7:105168472 C/A cg02135003 chr7:105160482 PUS7 -0.46 -5.44 -0.32 1.19e-7 Bipolar disorder (body mass index interaction); CESC cis rs17826219 0.500 rs2874724 chr17:29072433 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Body mass index; CESC cis rs17376456 1.000 rs12188453 chr5:93560807 G/T cg25358565 chr5:93447407 FAM172A -1.13 -10.51 -0.54 8.19e-22 Diabetic retinopathy; CESC trans rs1549733 0.577 rs16857849 chr2:218418133 C/T cg23408253 chr19:17438755 ANO8 -0.46 -6.01 -0.35 6.04e-9 Optic disc area; CESC cis rs7771547 0.573 rs10440841 chr6:36399086 G/A cg07856975 chr6:36356162 ETV7 -0.36 -5.38 -0.31 1.67e-7 Platelet distribution width; CESC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 12.57 0.61 9.43e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs8073060 0.544 rs225283 chr17:33934912 A/G cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs9911578 0.935 rs9911753 chr17:56983174 G/A cg12560992 chr17:57184187 TRIM37 0.81 12.55 0.61 1.15e-28 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26057283 chr7:73082469 VPS37D 0.58 6.89 0.39 3.96e-11 Gut microbiome composition (summer); CESC cis rs17376456 0.877 rs66696214 chr5:93424533 G/A cg25358565 chr5:93447407 FAM172A 1.18 11.22 0.57 3.75e-24 Diabetic retinopathy; CESC cis rs34779708 0.766 rs7897088 chr10:35551567 G/T cg04310649 chr10:35416472 CREM -0.48 -5.38 -0.31 1.62e-7 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06100147 chr7:143059260 FAM131B 0.54 6.07 0.35 4.37e-9 Gut microbiome composition (summer); CESC cis rs56104184 0.723 rs116909499 chr19:49407733 C/T cg15549821 chr19:49342101 PLEKHA4 -0.53 -5.47 -0.32 1.06e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg19077165 chr18:44547161 KATNAL2 -0.6 -9.21 -0.49 1.02e-17 Personality dimensions; CESC cis rs11203032 0.831 rs9651495 chr10:90932381 G/A cg16672925 chr10:90967113 CH25H 0.68 6.42 0.37 6.19e-10 Heart failure; CESC trans rs61931739 0.500 rs7489130 chr12:34539674 C/A cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg17724175 chr1:150552817 MCL1 0.41 6.23 0.36 1.82e-9 Melanoma; CESC cis rs4900109 0.590 rs4904870 chr14:92787008 A/G cg06884470 chr14:92785924 NA -0.29 -5.2 -0.3 4.04e-7 Iris characteristics; CESC cis rs711830 1.000 rs2857540 chr2:177026698 G/T cg13092806 chr2:177043255 NA 0.84 10.91 0.56 3.92e-23 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CESC cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.1 0.3 6.52e-7 Hip circumference adjusted for BMI; CESC cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg25427524 chr10:38739819 LOC399744 -0.66 -9.62 -0.51 5.39e-19 Extrinsic epigenetic age acceleration; CESC cis rs1475911 1.000 rs2839465 chr21:43511232 C/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.4 -5.81 -0.34 1.78e-8 IgG glycosylation; CESC cis rs938554 0.784 rs11726102 chr4:9951664 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs2742234 0.541 rs12220534 chr10:43734306 G/T cg15436174 chr10:43711423 RASGEF1A -0.44 -5.35 -0.31 1.86e-7 Hirschsprung disease; CESC cis rs6429082 0.634 rs3856245 chr1:235571428 G/A cg26050004 chr1:235667680 B3GALNT2 -0.54 -6.77 -0.38 8.47e-11 Adiposity; CESC cis rs2243480 1.000 rs316317 chr7:65613637 G/T cg12463550 chr7:65579703 CRCP 0.75 5.84 0.34 1.56e-8 Diabetic kidney disease; CESC cis rs2235544 0.639 rs6672989 chr1:54474472 T/C cg25741118 chr1:54482237 LDLRAD1 -0.27 -6.57 -0.37 2.72e-10 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -12.2 -0.6 1.78e-27 Alzheimer's disease; CESC cis rs4077515 0.967 rs11145874 chr9:139290011 G/A cg14169450 chr9:139327907 INPP5E 0.39 5.59 0.32 5.78e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs4728302 0.838 rs10224828 chr7:133591071 G/A cg10665199 chr7:133106180 EXOC4 0.39 5.39 0.31 1.55e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs2952156 0.920 rs12940986 chr17:37836581 A/G cg07936489 chr17:37558343 FBXL20 0.62 8.32 0.46 4.72e-15 Asthma; CESC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.65 9.04 0.49 3.4e-17 Menopause (age at onset); CESC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg00166722 chr3:10149974 C3orf24 0.46 5.67 0.33 3.8e-8 Alzheimer's disease; CESC cis rs854765 0.647 rs7406744 chr17:17981938 C/G cg04398451 chr17:18023971 MYO15A -0.76 -11.22 -0.57 3.76e-24 Total body bone mineral density; CESC cis rs7264396 0.790 rs6060565 chr20:34285442 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.89 -0.59 2.02e-26 Total cholesterol levels; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg22858966 chr12:89919202 WDR51B;GALNT4 0.46 6.07 0.35 4.47e-9 Bronchopulmonary dysplasia; CESC cis rs2629540 0.766 rs10794177 chr10:126407409 G/C cg08799069 chr10:126477246 METTL10 0.59 7.49 0.42 1.02e-12 Cocaine dependence; CESC cis rs9902453 0.904 rs4375718 chr17:28363642 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.74 -9.98 -0.52 4.18e-20 Coffee consumption (cups per day); CESC cis rs2070677 1.000 rs2515641 chr10:135351362 T/C cg20169779 chr10:135381914 SYCE1 0.65 7.69 0.43 2.94e-13 Gout; CESC cis rs67478160 0.584 rs2295148 chr14:104195610 T/C cg08213375 chr14:104286397 PPP1R13B 0.38 6.93 0.39 3.18e-11 Schizophrenia; CESC cis rs11168351 0.864 rs10875743 chr12:48498413 C/T cg04545296 chr12:48745243 ZNF641 -0.33 -5.64 -0.33 4.3e-8 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22788606 chr1:167424194 CD247 0.63 7.23 0.41 5.3e-12 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00630453 chr20:2821369 FAM113A;VPS16 -0.42 -6.05 -0.35 4.94e-9 Gambling; CESC cis rs9911578 0.967 rs4598970 chr17:57076893 T/A cg05425664 chr17:57184151 TRIM37 0.52 7.22 0.41 5.42e-12 Intelligence (multi-trait analysis); CESC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg19318889 chr4:1322082 MAEA 0.55 6.87 0.39 4.54e-11 Longevity; CESC cis rs7560272 0.538 rs2012574 chr2:73928366 G/C cg20560298 chr2:73613845 ALMS1 0.46 6.2 0.36 2.21e-9 Schizophrenia; CESC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg08736216 chr1:53307985 ZYG11A 0.4 6.35 0.36 9.55e-10 Monocyte count; CESC cis rs2898681 0.874 rs59649036 chr4:53741175 T/C cg00791764 chr4:53727839 RASL11B 0.36 5.25 0.31 3.12e-7 Optic nerve measurement (cup area); CESC cis rs3820068 0.529 rs79570154 chr1:15990912 T/C cg17385448 chr1:15911702 AGMAT 0.45 7.41 0.41 1.65e-12 Systolic blood pressure; CESC cis rs61931739 0.500 rs11053269 chr12:34545307 A/G cg06521331 chr12:34319734 NA -0.36 -5.03 -0.3 9.01e-7 Morning vs. evening chronotype; CESC cis rs116095464 0.558 rs10080225 chr5:232175 A/G cg10591111 chr5:226296 SDHA -0.53 -6.37 -0.36 8.13e-10 Breast cancer; CESC cis rs28647808 0.618 rs7025970 chr9:136267173 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.82 5.46 0.32 1.11e-7 Blood protein levels; CESC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg00750074 chr16:89608354 SPG7 -0.43 -6.18 -0.35 2.42e-9 Multiple myeloma (IgH translocation); CESC cis rs887829 0.569 rs4663965 chr2:234650604 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.58 -7.68 -0.43 3.03e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs4727963 0.846 rs1357946 chr7:122741080 G/T cg03640110 chr7:122635026 TAS2R16 -0.36 -5.42 -0.32 1.32e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs6460942 1.000 rs62448562 chr7:12398785 T/C cg06484146 chr7:12443880 VWDE -0.81 -8.88 -0.48 1.05e-16 Coronary artery disease; CESC cis rs67311347 1.000 rs4973878 chr3:40407565 C/T cg24209194 chr3:40518798 ZNF619 0.46 6.06 0.35 4.69e-9 Renal cell carcinoma; CESC cis rs763121 0.925 rs1043312 chr22:39131727 T/G cg06544989 chr22:39130855 UNC84B 0.46 8.46 0.46 1.83e-15 Menopause (age at onset); CESC cis rs2733201 1.000 rs12591537 chr15:44338263 T/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.65 -6.07 -0.35 4.52e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC trans rs4927850 0.723 rs7630825 chr3:195753740 T/C cg16724585 chr3:197361211 NA -0.57 -7.36 -0.41 2.33e-12 Pancreatic cancer; CESC cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg04450456 chr4:17643702 FAM184B 0.36 5.16 0.3 4.93e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1348850 0.634 rs2293471 chr2:178487729 T/G cg22681709 chr2:178499509 PDE11A -0.48 -6.44 -0.37 5.58e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7937682 0.883 rs1612013 chr11:111456293 A/G cg22437258 chr11:111473054 SIK2 0.71 9.1 0.49 2.27e-17 Primary sclerosing cholangitis; CESC cis rs2880765 0.835 rs7164106 chr15:86032590 T/C cg19183879 chr15:85880815 NA -0.25 -5.18 -0.3 4.49e-7 Coronary artery disease; CESC cis rs10899021 1.000 rs11236193 chr11:74368307 T/C cg25880958 chr11:74394337 NA -0.75 -7.16 -0.4 7.74e-12 Response to metformin (IC50); CESC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg07936489 chr17:37558343 FBXL20 0.8 11.43 0.57 7.13e-25 Glomerular filtration rate (creatinine); CESC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC cis rs854765 0.647 rs854790 chr17:18028318 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 7.98 0.44 4.4e-14 Total body bone mineral density; CESC cis rs643506 0.874 rs673679 chr11:111686800 C/T cg09085632 chr11:111637200 PPP2R1B 0.41 5.37 0.31 1.73e-7 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06564473 chr11:601660 PHRF1 -0.43 -6.46 -0.37 4.92e-10 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20594226 chr2:87035716 CD8A 0.55 6.14 0.35 3.03e-9 Gut microbiome composition (summer); CESC cis rs644799 0.710 rs3017756 chr11:95537358 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.77 10.82 0.55 8.02e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9399401 0.634 rs984932 chr6:142803037 C/T cg04461802 chr6:142623433 GPR126 0.36 5.62 0.33 4.84e-8 Chronic obstructive pulmonary disease; CESC cis rs12325245 0.536 rs12931124 chr16:58620063 G/A cg02549819 chr16:58548995 SETD6 0.94 6.09 0.35 3.94e-9 Schizophrenia; CESC cis rs7830933 0.955 rs57220043 chr8:23602763 A/T cg04349084 chr8:23602677 NA 0.43 5.36 0.31 1.8e-7 Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist-to-hip ratio adjusted for body mass index;Waist circumference adjusted for body mass index;Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI in non-smokers; CESC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.35 -0.36 9.17e-10 Developmental language disorder (linguistic errors); CESC cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg00825309 chr19:58991885 ZNF446 -0.55 -8.04 -0.44 2.95e-14 Uric acid clearance; CESC cis rs1881797 0.932 rs2387038 chr1:247674919 G/A cg11166453 chr1:247681781 NA 0.45 5.61 0.33 4.99e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs6754311 0.550 rs1438307 chr2:136499166 A/C cg15123519 chr2:136567270 LCT -0.29 -5.1 -0.3 6.45e-7 Mosquito bite size; CESC cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs3015497 0.603 rs3015449 chr14:51078076 A/C cg26011998 chr14:51135199 SAV1 -0.48 -5.43 -0.32 1.25e-7 Mean platelet volume; CESC cis rs2635047 0.638 rs2668760 chr18:44682891 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.7 0.33 3.21e-8 Educational attainment; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15540553 chr11:64018643 PLCB3 -0.46 -6.05 -0.35 4.87e-9 Ulcerative colitis; CESC cis rs4319547 0.661 rs7398014 chr12:122943980 T/C cg23029597 chr12:123009494 RSRC2 -0.48 -5.22 -0.31 3.53e-7 Body mass index; CESC cis rs10788309 0.506 rs11599263 chr10:85824118 A/G cg03623264 chr10:85672087 NA 0.36 5.09 0.3 6.73e-7 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); CESC cis rs3126085 0.825 rs12045492 chr1:152253866 A/T cg03465714 chr1:152285911 FLG -0.45 -5.53 -0.32 7.71e-8 Atopic dermatitis; CESC cis rs1278769 0.786 rs3742238 chr13:113540425 C/T cg00823993 chr13:113535758 ATP11A 0.58 7.56 0.42 6.46e-13 Interstitial lung disease; CESC trans rs561341 0.843 rs2028067 chr17:30239698 T/C cg27661571 chr11:113659931 NA -0.52 -6.08 -0.35 4.14e-9 Hip circumference adjusted for BMI; CESC cis rs9549367 0.789 rs34568744 chr13:113894564 G/T cg00898013 chr13:113819073 PROZ -0.51 -6.94 -0.39 3.06e-11 Platelet distribution width; CESC cis rs4654899 0.785 rs10916911 chr1:21290061 C/T cg05370193 chr1:21551575 ECE1 0.36 5.4 0.31 1.49e-7 Superior frontal gyrus grey matter volume; CESC trans rs35824328 0.706 rs76663547 chr2:215100054 A/G cg05754377 chr7:36124944 NA 0.59 6.05 0.35 5.04e-9 HIV-associated neurocognitive disorder (mild neurocognitive disorder); CESC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg27170947 chr2:26402098 FAM59B -0.71 -8.27 -0.45 6.5e-15 Gut microbiome composition (summer); CESC cis rs1348850 0.914 rs10170546 chr2:178248790 C/T cg23306229 chr2:178417860 TTC30B 0.64 8.0 0.44 3.87e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg05368731 chr17:41323189 NBR1 0.77 10.72 0.55 1.69e-22 Menopause (age at onset); CESC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg17949981 chr6:28129498 ZNF389 0.45 5.48 0.32 9.95e-8 Depression; CESC cis rs9300255 0.602 rs1790126 chr12:123683563 C/T cg19016782 chr12:123741754 C12orf65 -0.45 -6.4 -0.37 6.92e-10 Neutrophil percentage of white cells; CESC cis rs7084402 0.934 rs1649021 chr10:60286028 C/T cg07615347 chr10:60278583 BICC1 0.59 9.44 0.5 2.04e-18 Refractive error; CESC cis rs1788820 0.957 rs1652342 chr18:21099583 C/T cg14672496 chr18:21087552 C18orf8 0.53 7.19 0.4 6.58e-12 Body mass index; CESC cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg21918786 chr6:109611834 NA 0.41 6.21 0.36 2.06e-9 Reticulocyte fraction of red cells; CESC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -9.93 -0.52 5.93e-20 Alzheimer's disease; CESC cis rs9322193 0.884 rs7769115 chr6:150169932 C/T cg04369109 chr6:150039330 LATS1 -0.38 -5.1 -0.3 6.52e-7 Lung cancer; CESC cis rs10242455 0.702 rs78680379 chr7:99198573 G/A cg25640893 chr7:99214727 ZNF498 1.26 7.15 0.4 8.32e-12 Blood metabolite levels; CESC cis rs3820068 0.580 rs7556473 chr1:15996858 C/T cg17385448 chr1:15911702 AGMAT -0.41 -6.35 -0.36 9.45e-10 Systolic blood pressure; CESC cis rs2645694 0.626 rs2645705 chr4:77830434 G/A cg18351406 chr4:77819688 ANKRD56 0.53 6.34 0.36 9.71e-10 Emphysema distribution in smoking; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08216050 chr16:704013 WDR90 0.46 6.09 0.35 3.89e-9 Fibrinogen levels; CESC cis rs6540559 0.673 rs4556361 chr1:210019654 C/G cg21951975 chr1:209979733 IRF6 -0.56 -7.09 -0.4 1.23e-11 Cleft lip with or without cleft palate; CESC cis rs7932354 0.710 rs6485702 chr11:46898771 T/C cg25783544 chr11:47291846 MADD -0.39 -5.03 -0.3 8.94e-7 Bone mineral density (hip);Bone mineral density; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07264050 chr8:48920858 UBE2V2 -0.47 -6.08 -0.35 4.16e-9 Ulcerative colitis; CESC cis rs4727027 0.899 rs6464942 chr7:148826368 T/C cg23583168 chr7:148888333 NA -0.74 -10.89 -0.56 4.6e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg07395648 chr5:131743802 NA 0.4 5.18 0.3 4.39e-7 Breast cancer; CESC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg23221052 chr5:179740743 GFPT2 -0.59 -7.76 -0.43 1.89e-13 Height; CESC trans rs11098499 0.644 rs3986377 chr4:120260270 G/A cg25214090 chr10:38739885 LOC399744 0.61 8.64 0.47 5.49e-16 Corneal astigmatism; CESC trans rs7902708 0.920 rs11003035 chr10:54428726 G/A cg26219051 chr22:43739629 SCUBE1 -0.47 -6.05 -0.35 5e-9 Bone properties (heel); CESC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg26850624 chr5:429559 AHRR -0.5 -6.67 -0.38 1.52e-10 Cystic fibrosis severity; CESC cis rs7927771 0.524 rs7933184 chr11:47682402 C/T cg20307385 chr11:47447363 PSMC3 0.62 8.65 0.47 5.03e-16 Subjective well-being; CESC cis rs634534 0.532 rs12794370 chr11:65770413 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.75 0.38 9.17e-11 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs977987 0.806 rs11643410 chr16:75428306 C/T cg03315344 chr16:75512273 CHST6 0.4 5.7 0.33 3.21e-8 Dupuytren's disease; CESC trans rs13098911 0.540 rs17215981 chr3:46124418 C/T cg10236987 chr1:228114221 WNT9A -0.61 -6.36 -0.36 8.64e-10 Celiac disease; CESC cis rs9473147 0.543 rs9296559 chr6:47452270 T/C cg20196966 chr6:47445060 CD2AP 0.4 5.19 0.3 4.26e-7 Platelet distribution width;Mean platelet volume; CESC cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 0.522 rs431168 chr7:65511604 G/T cg13147721 chr7:65941812 NA -0.88 -6.59 -0.38 2.35e-10 Diabetic kidney disease; CESC cis rs2011503 0.943 rs8102502 chr19:19652746 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.54 5.83 0.34 1.61e-8 Bipolar disorder; CESC cis rs28830936 1.000 rs17678138 chr15:42043067 G/A cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.37 -5.43 -0.32 1.25e-7 Diastolic blood pressure; CESC cis rs7762018 0.660 rs41265385 chr6:170068086 C/T cg13891659 chr6:170190454 C6orf122;C6orf208 0.56 5.43 0.32 1.25e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs16854884 0.837 rs7644767 chr3:143803092 C/G cg06585982 chr3:143692056 C3orf58 0.44 5.44 0.32 1.24e-7 Economic and political preferences (feminism/equality); CESC cis rs10911232 0.507 rs4651137 chr1:182994300 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC trans rs7922314 0.571 rs61865691 chr10:64728320 C/T cg06935979 chr1:232941706 KIAA1383 -0.66 -5.99 -0.35 6.67e-9 Cutaneous psoriasis; CESC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg24675658 chr1:53192096 ZYG11B -0.56 -7.26 -0.41 4.43e-12 Monocyte count; CESC cis rs9914988 0.887 rs11650282 chr17:27090741 C/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs4423214 0.650 rs7940244 chr11:71221574 C/T cg05163923 chr11:71159392 DHCR7 -0.76 -9.57 -0.51 7.73e-19 Vitamin D levels; CESC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs561341 0.769 rs7217004 chr17:30178092 A/G cg19193384 chr17:30244184 NA 0.6 5.7 0.33 3.19e-8 Hip circumference adjusted for BMI; CESC cis rs7259376 0.837 rs16999542 chr19:22573092 A/C cg02657401 chr19:22469223 NA -0.26 -5.14 -0.3 5.27e-7 Menopause (age at onset); CESC trans rs7922314 0.571 rs57110080 chr10:64736699 G/A cg06935979 chr1:232941706 KIAA1383 -0.63 -6.12 -0.35 3.3e-9 Cutaneous psoriasis; CESC trans rs2727020 0.729 rs4980439 chr11:49342246 G/C cg03929089 chr4:120376271 NA -0.79 -11.98 -0.59 9.9e-27 Coronary artery disease; CESC cis rs2439831 0.867 rs2447208 chr15:43933895 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.64 7.89 0.44 7.73e-14 Lung cancer in ever smokers; CESC cis rs8067354 0.645 rs28516945 chr17:57816578 T/C cg02344993 chr17:57696989 CLTC 0.67 7.83 0.43 1.2e-13 Hemoglobin concentration; CESC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg15445000 chr17:37608096 MED1 -0.42 -6.81 -0.39 6.57e-11 Glomerular filtration rate (creatinine); CESC cis rs977987 0.806 rs35937717 chr16:75331567 C/A cg03315344 chr16:75512273 CHST6 0.39 5.6 0.33 5.24e-8 Dupuytren's disease; CESC cis rs12681288 0.676 rs17740799 chr8:1014327 C/T cg15309053 chr8:964076 NA -0.41 -7.04 -0.4 1.69e-11 Schizophrenia; CESC cis rs2204008 0.692 rs11613378 chr12:38213138 T/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg17971929 chr21:40555470 PSMG1 1.04 15.91 0.7 1.8e-40 Cognitive function; CESC cis rs7927592 0.956 rs10896337 chr11:68284236 T/C cg20283391 chr11:68216788 NA -0.5 -6.03 -0.35 5.4e-9 Total body bone mineral density; CESC cis rs1062177 1.000 rs72802204 chr5:151183183 T/C cg00977110 chr5:151150581 G3BP1 0.63 6.88 0.39 4.37e-11 Preschool internalizing problems; CESC cis rs1371867 0.846 rs1660347 chr8:101314980 G/A cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.1e-11 Atrioventricular conduction; CESC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg17376030 chr22:41985996 PMM1 -0.7 -7.54 -0.42 7.31e-13 Vitiligo; CESC cis rs10097731 0.901 rs9298344 chr8:82043063 C/T cg25230327 chr8:82042993 NA -0.55 -6.22 -0.36 1.91e-9 Serum total protein level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09452751 chr3:155572485 SLC33A1 0.61 6.79 0.38 7.29e-11 Gut microbiome composition (summer); CESC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg17372223 chr3:52568218 NT5DC2 0.42 6.35 0.36 9.14e-10 Electroencephalogram traits; CESC cis rs977987 0.806 rs4888391 chr16:75400746 C/T cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.73e-8 Dupuytren's disease; CESC cis rs67478160 0.643 rs2887282 chr14:104280734 A/G cg01849466 chr14:104193079 ZFYVE21 -0.46 -6.41 -0.37 6.58e-10 Schizophrenia; CESC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg04287289 chr16:89883240 FANCA 0.91 16.04 0.7 6.43e-41 Vitiligo; CESC cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg24296786 chr1:45957014 TESK2 0.68 9.36 0.5 3.55e-18 High light scatter reticulocyte count; CESC cis rs9858542 0.953 rs9837027 chr3:49597013 C/T cg03060546 chr3:49711283 APEH -0.51 -5.96 -0.34 7.9e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7264396 0.635 rs6060660 chr20:34476649 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -11.5 -0.58 4.39e-25 Total cholesterol levels; CESC cis rs9807841 0.592 rs10401513 chr19:10778763 A/T cg17710535 chr19:10819994 QTRT1 0.37 5.12 0.3 5.82e-7 Inflammatory skin disease; CESC cis rs7223966 1.000 rs8075422 chr17:61804686 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.32 0.41 3.01e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs397969 0.646 rs17604987 chr17:19867331 A/T cg12073167 chr17:19770448 ULK2 0.44 5.13 0.3 5.72e-7 Platelet count; CESC cis rs10463316 0.817 rs3846713 chr5:150799739 C/T cg03212797 chr5:150827313 SLC36A1 -0.52 -6.69 -0.38 1.3100000000000001e-10 Metabolite levels (Pyroglutamine); CESC cis rs8017423 0.935 rs10147186 chr14:90779879 G/C cg14092571 chr14:90743983 NA -0.53 -8.12 -0.45 1.78e-14 Mortality in heart failure; CESC cis rs6714016 0.600 rs12713004 chr2:23896049 A/G cg20701182 chr2:24300061 SF3B14 -0.42 -5.15 -0.3 5.1e-7 Plateletcrit; CESC cis rs2635047 0.747 rs9956387 chr18:44773382 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 5.79 0.34 2.01e-8 Educational attainment; CESC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg20151795 chr6:28129481 ZNF389 0.41 5.46 0.32 1.09e-7 Depression; CESC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg03352830 chr11:487213 PTDSS2 0.72 6.98 0.39 2.31e-11 Body mass index; CESC cis rs5763662 1.000 rs5763810 chr22:30541670 G/A cg21388335 chr22:29999516 NF2 -0.74 -5.03 -0.3 9.22e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs11112613 0.713 rs73184084 chr12:105952615 T/A cg03607813 chr12:105948248 NA 0.59 7.41 0.41 1.75e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs1707322 0.716 rs10890342 chr1:46157087 C/T cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1218582 0.661 rs4845695 chr1:154911798 A/G cg06221963 chr1:154839813 KCNN3 -0.59 -9.37 -0.5 3.4e-18 Prostate cancer; CESC trans rs17508449 0.547 rs3195954 chr1:114354654 T/C cg23028848 chr11:57092561 TNKS1BP1 -0.65 -6.01 -0.35 6.03e-9 Leprosy; CESC cis rs2072732 0.861 rs55873718 chr1:2940012 A/G cg03976712 chr1:2946727 NA 0.34 5.31 0.31 2.28e-7 Plateletcrit; CESC cis rs4604732 0.588 rs74154678 chr1:247626202 A/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9399137 0.507 rs7772031 chr6:135259734 G/A cg22676075 chr6:135203613 NA -0.57 -7.67 -0.43 3.36e-13 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16636182 chr19:5112710 KDM4B 0.49 6.48 0.37 4.57e-10 Fibrinogen levels; CESC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg00166722 chr3:10149974 C3orf24 0.48 5.98 0.34 7.06e-9 Alzheimer's disease; CESC cis rs4835473 0.808 rs62339607 chr4:144712627 C/A cg25736465 chr4:144833511 NA -0.36 -5.84 -0.34 1.5e-8 Immature fraction of reticulocytes; CESC cis rs3820928 0.904 rs4129884 chr2:227820943 G/A cg05526886 chr2:227700861 RHBDD1 -0.4 -5.12 -0.3 5.97e-7 Pulmonary function; CESC cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg24308560 chr3:49941425 MST1R 0.6 8.72 0.47 3.17e-16 Body mass index; CESC cis rs34779708 0.733 rs4934740 chr10:35547141 C/T cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs881375 0.933 rs1548784 chr9:123685280 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 5.24 0.31 3.22e-7 Rheumatoid arthritis; CESC cis rs7617773 0.817 rs745116 chr3:48272536 T/G cg11946769 chr3:48343235 NME6 0.79 10.77 0.55 1.16e-22 Coronary artery disease; CESC cis rs2439831 1.000 rs9920763 chr15:43760508 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.94 9.77 0.51 1.81e-19 Lung cancer in ever smokers; CESC cis rs965513 0.530 rs7357631 chr9:100528320 G/A cg13688889 chr9:100608707 NA -0.42 -5.48 -0.32 9.84e-8 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs3820068 0.705 rs11584398 chr1:15880275 G/A cg18192808 chr1:15853278 DNAJC16 0.47 5.69 0.33 3.33e-8 Systolic blood pressure; CESC cis rs2274273 0.870 rs10144345 chr14:55847737 T/C cg04306507 chr14:55594613 LGALS3 0.31 6.09 0.35 4.04e-9 Protein biomarker; CESC cis rs644799 0.710 rs12272061 chr11:95524067 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.74 10.88 0.56 5.03e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7618501 0.699 rs1317154 chr3:49910084 T/C cg24110177 chr3:50126178 RBM5 -0.46 -6.09 -0.35 4.06e-9 Intelligence (multi-trait analysis); CESC cis rs12134040 0.646 rs10925102 chr1:236507727 G/T cg21399712 chr1:236511386 NA -0.37 -5.12 -0.3 5.78e-7 Urate levels (BMI interaction); CESC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg18337363 chr3:52569053 NT5DC2 0.28 5.07 0.3 7.31e-7 Bipolar disorder; CESC cis rs763121 0.853 rs3747170 chr22:39067331 G/A cg21395723 chr22:39101663 GTPBP1 0.42 5.33 0.31 2.15e-7 Menopause (age at onset); CESC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.69 0.38 1.3100000000000001e-10 Electroencephalogram traits; CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.37 -5.49 -0.32 9.2e-8 Bipolar disorder; CESC cis rs11650494 0.710 rs16948071 chr17:47468706 T/G cg08112188 chr17:47440006 ZNF652 1.19 8.04 0.44 3.04e-14 Prostate cancer; CESC trans rs3780486 0.718 rs10971418 chr9:33122024 A/C cg20290983 chr6:43655470 MRPS18A -0.69 -8.33 -0.46 4.52e-15 IgG glycosylation; CESC cis rs863345 1.000 rs863351 chr1:158538663 G/T cg12129480 chr1:158549410 OR10X1 -0.32 -6.42 -0.37 6.4e-10 Pneumococcal bacteremia; CESC cis rs61776719 0.520 rs17465651 chr1:38418496 C/T cg12658694 chr1:38397304 INPP5B 0.64 9.07 0.49 2.83e-17 Coronary artery disease; CESC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg22433210 chr17:43662623 NA 0.61 8.0 0.44 3.78e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7818345 0.967 rs13258090 chr8:19285726 A/G cg11303988 chr8:19266685 CSGALNACT1 -0.37 -6.96 -0.39 2.67e-11 Language performance in older adults (adjusted for episodic memory); CESC cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs60154123 0.505 rs7540237 chr1:210053325 C/T cg22029157 chr1:209979665 IRF6 0.72 7.3 0.41 3.39e-12 Coronary artery disease; CESC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs921968 0.541 rs581013 chr2:219432040 G/T cg02176678 chr2:219576539 TTLL4 0.5 8.91 0.48 8.15e-17 Mean corpuscular hemoglobin concentration; CESC cis rs4268898 0.662 rs74470633 chr2:24438712 A/G cg08917208 chr2:24149416 ATAD2B 0.55 5.27 0.31 2.89e-7 Asthma; CESC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs11059919 1 rs11059919 chr12:129289190 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -9.72 -0.51 2.64e-19 Systemic lupus erythematosus; CESC cis rs9911578 0.933 rs2632508 chr17:56533235 G/A cg05425664 chr17:57184151 TRIM37 -0.48 -6.62 -0.38 2.04e-10 Intelligence (multi-trait analysis); CESC cis rs7762018 0.505 rs79843499 chr6:170068420 A/G cg19338460 chr6:170058176 WDR27 -0.99 -8.06 -0.44 2.62e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1950626 0.743 rs1956734 chr14:101399830 A/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.76 -9.68 -0.51 3.65e-19 Pelvic organ prolapse (moderate/severe); CESC cis rs6894249 1.000 rs6894249 chr5:131797547 A/G cg00255919 chr5:131827918 IRF1 0.37 6.13 0.35 3.16e-9 Asthma; CESC cis rs11122272 0.735 rs2808591 chr1:231523421 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg04267008 chr7:1944627 MAD1L1 -0.6 -7.23 -0.41 5.11e-12 Bipolar disorder and schizophrenia; CESC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.63 -0.38 1.85e-10 Bipolar disorder; CESC cis rs9916302 0.861 rs11078896 chr17:37415544 C/T cg07936489 chr17:37558343 FBXL20 -0.77 -10.78 -0.55 1.03e-22 Glomerular filtration rate (creatinine); CESC cis rs1461503 0.966 rs1461504 chr11:122845129 T/C cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs2742234 0.541 rs11238483 chr10:43728780 A/G cg15436174 chr10:43711423 RASGEF1A 0.47 5.5 0.32 8.97e-8 Hirschsprung disease; CESC cis rs3768617 0.565 rs3768626 chr1:183078462 A/G ch.1.3577855R chr1:183094577 LAMC1 0.88 14.14 0.66 3.44e-34 Fuchs's corneal dystrophy; CESC cis rs9486719 0.947 rs9386648 chr6:97035656 T/C cg18709589 chr6:96969512 KIAA0776 -0.5 -5.44 -0.32 1.21e-7 Migraine;Coronary artery disease; CESC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg08027265 chr7:2291960 NA -0.46 -7.17 -0.4 7.65e-12 Bipolar disorder and schizophrenia; CESC cis rs1801251 1.000 rs12474040 chr2:233615345 T/G cg25237894 chr2:233734115 C2orf82 0.45 7.97 0.44 4.79e-14 Coronary artery disease; CESC cis rs9640161 0.789 rs28439010 chr7:150046276 C/T cg10018233 chr7:150070692 REPIN1 0.36 5.17 0.3 4.71e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs113835537 0.935 rs15969 chr11:66394387 C/T cg22134325 chr11:66188745 NPAS4 0.5 5.76 0.33 2.27e-8 Airway imaging phenotypes; CESC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Depression; CESC cis rs1577917 1.000 rs36096931 chr6:86693134 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -5.94 -0.34 8.79e-9 Response to antipsychotic treatment; CESC cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg05340658 chr4:99064831 C4orf37 0.76 11.43 0.57 7.54e-25 Colonoscopy-negative controls vs population controls; CESC cis rs7264396 0.635 rs6060720 chr20:34548336 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.2 0.36 2.18e-9 Total cholesterol levels; CESC cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg06636001 chr8:8085503 FLJ10661 0.51 6.26 0.36 1.53e-9 Mood instability; CESC cis rs6580649 0.941 rs4760618 chr12:48434767 G/A cg24011408 chr12:48396354 COL2A1 -0.41 -5.1 -0.3 6.53e-7 Lung cancer; CESC cis rs72634258 0.945 rs1883679 chr1:8100451 T/G cg00042356 chr1:8021962 PARK7 0.76 6.78 0.38 7.86e-11 Inflammatory bowel disease; CESC cis rs6446731 0.734 rs10937921 chr4:3276491 C/T cg08886695 chr4:3369023 RGS12 -0.35 -5.17 -0.3 4.53e-7 Mean platelet volume; CESC cis rs2276314 0.947 rs16967319 chr18:33573525 A/G cg19628046 chr18:33552617 C18orf21 0.54 5.77 0.33 2.17e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs1395 0.778 rs11693001 chr2:27412744 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 5.85 0.34 1.44e-8 Blood metabolite levels; CESC cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12971120 0.891 rs71359051 chr18:72169723 G/A cg25817165 chr18:72167213 CNDP2 -0.58 -7.13 -0.4 9.45e-12 Refractive error; CESC cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs5758659 0.714 rs2413668 chr22:42505841 G/A cg00645731 chr22:42541494 CYP2D7P1 0.32 5.55 0.32 6.8e-8 Cognitive function; CESC cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg12648201 chr2:27665141 KRTCAP3 -0.33 -6.04 -0.35 5.19e-9 Total body bone mineral density; CESC cis rs72781680 0.898 rs79023848 chr2:24038174 C/A cg08917208 chr2:24149416 ATAD2B 1.13 10.18 0.53 9.42e-21 Lymphocyte counts; CESC cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6429637 0.582 rs37454 chr1:44294411 C/A cg11704212 chr1:44303111 ST3GAL3 -0.41 -5.42 -0.32 1.32e-7 Intelligence (multi-trait analysis); CESC cis rs826838 0.586 rs1843903 chr12:38627524 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.82 0.43 1.25e-13 Heart rate; CESC cis rs7818688 0.614 rs7834966 chr8:95847196 G/T cg16049864 chr8:95962084 TP53INP1 -0.49 -5.19 -0.3 4.16e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21605566 chr1:14075549 PRDM2 0.46 6.4 0.37 6.95e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1865721 1.000 rs72977879 chr18:73193696 T/C cg26385618 chr18:73139727 C18orf62 -0.51 -7.56 -0.42 6.81e-13 Intelligence; CESC cis rs8060686 0.668 rs12448991 chr16:68218894 T/A cg26727032 chr16:67993705 SLC12A4 -0.53 -5.99 -0.35 6.85e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs7680126 0.633 rs4697745 chr4:10305081 G/A cg00071950 chr4:10020882 SLC2A9 -0.49 -5.29 -0.31 2.53e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg14926445 chr8:58193284 C8orf71 -0.54 -5.16 -0.3 4.76e-7 Developmental language disorder (linguistic errors); CESC cis rs28829049 1.000 rs28829049 chr1:19349281 C/T cg13387374 chr1:19411106 UBR4 0.42 5.1 0.3 6.42e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27279809 chr12:49183212 ADCY6 -0.44 -6.11 -0.35 3.47e-9 Fibrinogen levels; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg00721635 chr1:153572208 NA -0.42 -6.03 -0.35 5.54e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg22875332 chr1:76189707 ACADM -0.57 -6.17 -0.35 2.5e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs5167 0.525 rs10402642 chr19:45453878 G/A cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.23e-14 Blood protein levels; CESC cis rs5771069 0.933 rs137848 chr22:50440296 A/G cg03721641 chr22:50451245 IL17REL 0.34 5.66 0.33 3.95e-8 Ulcerative colitis; CESC cis rs2228479 0.850 rs117880578 chr16:89910230 C/G cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs7824557 0.701 rs4568582 chr8:11160495 A/T cg21775007 chr8:11205619 TDH 0.52 7.6 0.42 5.01e-13 Retinal vascular caliber; CESC cis rs2735413 0.918 rs4309408 chr16:78071507 G/A cg04733911 chr16:78082701 NA -0.54 -8.96 -0.48 5.9e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.24 0.6 1.32e-27 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.954 rs7654587 chr4:120388406 C/T cg09307838 chr4:120376055 NA 0.95 13.96 0.65 1.42e-33 Corneal astigmatism; CESC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg25036284 chr2:26402008 FAM59B -0.58 -6.72 -0.38 1.09e-10 Gut microbiome composition (summer); CESC cis rs12142240 0.698 rs17361819 chr1:46828109 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.01 0.44 3.75e-14 Menopause (age at onset); CESC cis rs11249608 0.636 rs6888567 chr5:178449074 C/T cg01312482 chr5:178451176 ZNF879 0.44 6.03 0.35 5.63e-9 Pubertal anthropometrics; CESC cis rs6087990 0.865 rs6058859 chr20:31335157 A/G cg13636640 chr20:31349939 DNMT3B 0.84 14.64 0.67 5.74e-36 Ulcerative colitis; CESC cis rs2243480 1.000 rs34970380 chr7:65431493 C/T cg18252515 chr7:66147081 NA -1.2 -11.63 -0.58 1.53e-25 Diabetic kidney disease; CESC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg06873352 chr17:61820015 STRADA -0.72 -12.78 -0.62 1.85e-29 Prudent dietary pattern; CESC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg02935154 chr7:12443704 VWDE -0.57 -7.1 -0.4 1.17e-11 Coronary artery disease; CESC cis rs6448317 0.954 rs35276311 chr4:24923493 C/T cg21108841 chr4:24914750 CCDC149 -0.57 -6.85 -0.39 5.04e-11 Heschl's gyrus morphology; CESC cis rs854765 0.718 rs6502629 chr17:17869642 A/G cg04398451 chr17:18023971 MYO15A -0.64 -8.63 -0.47 5.78e-16 Total body bone mineral density; CESC cis rs12369179 1.000 rs12369179 chr12:122963550 C/T cg18578876 chr12:123200353 GPR109B -0.91 -7.16 -0.4 7.72e-12 Age-related diseases, mortality and associated endophenotypes;Age-related disease endophenotypes; CESC trans rs3942852 0.726 rs10742836 chr11:48175831 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -8.67 -0.47 4.34e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs2243480 0.522 rs431168 chr7:65511604 G/T cg25894440 chr7:65020034 NA -0.74 -5.19 -0.3 4.12e-7 Diabetic kidney disease; CESC cis rs10979 1.000 rs34960207 chr6:143886398 C/T cg25407410 chr6:143891975 LOC285740 -0.63 -9.62 -0.51 5.62e-19 Hypospadias; CESC cis rs12291225 0.535 rs16930126 chr11:14404983 C/T cg19336497 chr11:14380999 RRAS2 0.36 5.39 0.31 1.54e-7 Sense of smell; CESC cis rs9359856 0.564 rs72913921 chr6:90328692 A/T cg13799429 chr6:90582589 CASP8AP2 -0.63 -6.02 -0.35 5.88e-9 Bipolar disorder; CESC cis rs7188697 0.845 rs1981960 chr16:58597289 C/G cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg00677455 chr12:58241039 CTDSP2 0.52 6.62 0.38 2.03e-10 Multiple sclerosis; CESC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg03351412 chr1:154909251 PMVK 0.53 6.35 0.36 9.17e-10 Prostate cancer; CESC cis rs3812762 0.957 rs6484008 chr11:8754148 A/G cg03980550 chr11:8754370 ST5 0.36 5.3 0.31 2.4e-7 Hypospadias; CESC cis rs9649465 1.000 rs13225220 chr7:123371026 C/A cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.46e-7 Migraine; CESC cis rs8070740 0.786 rs12761 chr17:5326145 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.44 0.37 5.73e-10 Menopause (age at onset); CESC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.7 -7.98 -0.44 4.48e-14 Gut microbiome composition (summer); CESC cis rs2370759 1.000 rs11599044 chr10:32615445 A/G cg01819863 chr10:32635814 EPC1 1.14 12.39 0.61 4.11e-28 Sexual dysfunction (female); CESC cis rs6963495 0.818 rs55825845 chr7:105166713 A/G cg13798780 chr7:105162888 PUS7 0.78 8.02 0.44 3.36e-14 Bipolar disorder (body mass index interaction); CESC cis rs951366 0.677 rs1775140 chr1:205672107 C/A cg06877462 chr1:205807181 PM20D1 0.37 5.17 0.3 4.52e-7 Menarche (age at onset); CESC cis rs10782582 0.593 rs11578480 chr1:76208989 T/G cg22875332 chr1:76189707 ACADM -0.45 -5.33 -0.31 2.13e-7 Daytime sleep phenotypes; CESC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg11644478 chr21:40555479 PSMG1 -0.56 -7.67 -0.43 3.32e-13 Menarche (age at onset); CESC cis rs6750047 0.546 rs985257 chr2:38283228 A/T cg07380506 chr2:38303506 CYP1B1 -0.47 -6.03 -0.35 5.44e-9 Cutaneous malignant melanoma;Melanoma; CESC cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg19318889 chr4:1322082 MAEA 0.44 5.56 0.32 6.51e-8 Obesity-related traits; CESC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg04166393 chr7:2884313 GNA12 0.58 7.52 0.42 8.33e-13 Height; CESC cis rs6460942 0.915 rs10267801 chr7:12451931 G/A cg02935154 chr7:12443704 VWDE -0.53 -6.58 -0.37 2.54e-10 Coronary artery disease; CESC cis rs7605827 0.930 rs6431708 chr2:15638175 C/T cg19274914 chr2:15703543 NA 0.37 6.64 0.38 1.76e-10 Educational attainment (years of education); CESC cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg24450063 chr1:156163899 SLC25A44 1.1 23.34 0.82 3.27e-66 Testicular germ cell tumor; CESC cis rs7584330 0.695 rs6709497 chr2:238368925 C/T cg14458575 chr2:238380390 NA 0.6 8.18 0.45 1.17e-14 Prostate cancer; CESC cis rs7918232 0.607 rs1755401 chr10:27405763 A/C cg14240646 chr10:27532245 ACBD5 -0.73 -5.6 -0.33 5.28e-8 Breast cancer; CESC cis rs9303401 0.659 rs62081314 chr17:56778328 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC cis rs9322193 0.884 rs1108889 chr6:150166569 A/G cg09699651 chr6:150184138 LRP11 0.47 5.86 0.34 1.35e-8 Lung cancer; CESC cis rs62229266 0.626 rs7280896 chr21:37460906 G/A cg08632701 chr21:37451849 NA -0.54 -8.19 -0.45 1.14e-14 Mitral valve prolapse; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10380289 chr1:149399187 HIST2H2BF -0.52 -6.18 -0.35 2.35e-9 Gut microbiome composition (summer); CESC cis rs1401999 1.000 rs6802849 chr3:183698943 A/C cg01324343 chr3:183735012 ABCC5 0.64 13.63 0.64 2.08e-32 Anterior chamber depth; CESC cis rs6752107 0.967 rs3816234 chr2:234185999 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.69 0.38 1.3e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs10857712 0.754 rs2297032 chr10:135234580 C/T cg22671611 chr10:135291010 NA -0.34 -5.09 -0.3 6.67e-7 Systemic lupus erythematosus; CESC cis rs2963155 0.518 rs853177 chr5:142635460 A/G cg17617527 chr5:142782415 NR3C1 0.84 7.84 0.43 1.08e-13 Breast cancer; CESC cis rs7100689 0.622 rs2994389 chr10:82062257 C/G cg00277334 chr10:82204260 NA -0.61 -8.08 -0.44 2.35e-14 Post bronchodilator FEV1; CESC cis rs9902453 0.967 rs7212741 chr17:28322941 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 7.92 0.44 6.76e-14 Coffee consumption (cups per day); CESC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.47 6.3 0.36 1.22e-9 Lymphocyte counts; CESC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg09699651 chr6:150184138 LRP11 0.4 5.11 0.3 6.31e-7 Lung cancer; CESC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg17949981 chr6:28129498 ZNF389 0.47 5.93 0.34 9.24e-9 Depression; CESC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg23590916 chr17:43697445 MGC57346 0.6 6.42 0.37 6.12e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg08862778 chr1:11322643 MTOR 0.47 6.26 0.36 1.5e-9 Obesity-related traits; CESC cis rs7208859 0.524 rs77498725 chr17:29063986 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7210086 0.768 rs4075985 chr17:70640873 C/G cg04206342 chr17:70636940 NA -0.3 -5.84 -0.34 1.54e-8 Ulcerative colitis; CESC cis rs861020 0.771 rs629150 chr1:209998467 C/T cg05527609 chr1:210001259 C1orf107 1.08 14.81 0.67 1.4e-36 Orofacial clefts; CESC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg13393036 chr8:95962371 TP53INP1 -0.47 -10.01 -0.52 3.27e-20 Type 2 diabetes; CESC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg18252515 chr7:66147081 NA -0.44 -5.64 -0.33 4.42e-8 Aortic root size; CESC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg18301423 chr5:131593218 PDLIM4 0.38 5.39 0.31 1.59e-7 Breast cancer; CESC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4237845 0.788 rs6581157 chr12:58288793 C/T cg02175503 chr12:58329896 NA 0.61 7.33 0.41 2.85e-12 Intelligence (multi-trait analysis); CESC cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg20891283 chr12:69753455 YEATS4 0.6 8.51 0.46 1.3e-15 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23359810 chr10:51572113 NCOA4 -0.68 -8.35 -0.46 3.88e-15 Gut microbiome composition (summer); CESC cis rs2066819 1.000 rs77120931 chr12:56646213 A/C cg26734620 chr12:56694298 CS 1.03 6.78 0.38 7.71e-11 Psoriasis vulgaris; CESC cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg11752832 chr7:134001865 SLC35B4 0.55 7.23 0.41 5.27e-12 Mean platelet volume; CESC trans rs2727020 0.786 rs10839263 chr11:49354462 A/G cg15704280 chr7:45808275 SEPT13 -0.75 -9.28 -0.5 6.33e-18 Coronary artery disease; CESC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.55 -7.36 -0.41 2.37e-12 Menarche (age at onset); CESC cis rs4319547 0.656 rs10773075 chr12:122814236 G/A cg05707623 chr12:122985044 ZCCHC8 -0.48 -5.6 -0.33 5.34e-8 Body mass index; CESC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg14893161 chr1:205819251 PM20D1 0.39 5.12 0.3 5.9e-7 Parkinson's disease; CESC cis rs6835098 0.962 rs10027704 chr4:174083107 T/C cg08422745 chr4:174089978 GALNT7 -0.83 -11.79 -0.59 4.45e-26 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg23985595 chr17:80112537 CCDC57 0.41 6.46 0.37 5.01e-10 Life satisfaction; CESC cis rs9916302 0.904 rs1966916 chr17:37425238 T/G cg07936489 chr17:37558343 FBXL20 -0.8 -11.48 -0.58 5.11e-25 Glomerular filtration rate (creatinine); CESC cis rs10242455 0.702 rs73397481 chr7:99030108 C/T cg18809830 chr7:99032528 PTCD1 -0.82 -5.83 -0.34 1.6e-8 Blood metabolite levels; CESC cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11583043 0.918 rs6577216 chr1:101409972 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.55 6.27 0.36 1.44e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs3785574 0.962 rs2727280 chr17:61918082 A/G cg06420487 chr17:61919686 SMARCD2 0.45 5.24 0.31 3.34e-7 Height; CESC cis rs6460942 0.818 rs7780083 chr7:12233647 C/T cg06484146 chr7:12443880 VWDE -0.47 -5.22 -0.31 3.54e-7 Coronary artery disease; CESC cis rs7274811 0.779 rs13039908 chr20:32052070 G/A cg21523528 chr20:32077966 CBFA2T2 0.59 6.99 0.39 2.18e-11 Height; CESC cis rs12220238 1.000 rs4320897 chr10:76017732 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.92 0.34 1e-8 Soluble interleukin-2 receptor subunit alpha; CESC cis rs17376456 0.569 rs7732578 chr5:93410244 C/T cg25358565 chr5:93447407 FAM172A -0.48 -5.6 -0.33 5.38e-8 Diabetic retinopathy; CESC trans rs9858542 0.903 rs11917431 chr3:49644012 C/T cg21659725 chr3:3221576 CRBN -0.52 -6.35 -0.36 9.34e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs933688 1.000 rs7715402 chr5:90679504 T/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.94 12.6 0.61 7.96e-29 Smoking behavior; CESC cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg07636037 chr3:49044803 WDR6 1.05 19.44 0.77 6.31e-53 Parkinson's disease; CESC cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg20503657 chr10:835505 NA 0.74 7.45 0.42 1.34e-12 Eosinophil percentage of granulocytes; CESC cis rs34779708 0.702 rs4244995 chr10:35547175 A/G cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs2594989 0.943 rs7622627 chr3:11357419 T/C cg00170343 chr3:11313890 ATG7 0.59 5.25 0.31 3.1e-7 Circulating chemerin levels; CESC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg27170947 chr2:26402098 FAM59B 0.75 8.39 0.46 2.88e-15 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06828538 chr7:5463627 TNRC18 -0.69 -8.38 -0.46 3.23e-15 Gut microbiome composition (summer); CESC trans rs9929218 1.000 rs13333528 chr16:68790502 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.71 -8.86 -0.48 1.15e-16 Colorectal cancer; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg08874598 chr8:102217901 ZNF706 -0.42 -6.22 -0.36 1.94e-9 Breast cancer; CESC cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg26597838 chr10:835615 NA 0.91 9.95 0.52 5.15e-20 Eosinophil percentage of granulocytes; CESC cis rs6669072 0.669 rs814545 chr1:91240551 C/G cg08895590 chr1:91227319 NA -0.33 -5.73 -0.33 2.75e-8 Cognitive function; CESC cis rs8014204 0.870 rs3742790 chr14:75308758 C/T cg08847533 chr14:75593920 NEK9 -0.5 -6.46 -0.37 5.06e-10 Caffeine consumption; CESC cis rs3796352 1.000 rs17052727 chr3:53070914 T/C cg12962167 chr3:53033115 SFMBT1 0.55 5.04 0.3 8.53e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs34779708 0.733 rs3853672 chr10:35549606 A/C cg03585969 chr10:35415529 CREM 0.54 6.2 0.36 2.16e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08118908 chr16:15787920 NDE1 -0.55 -6.52 -0.37 3.55e-10 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19782173 chr5:76383047 LOC728723;ZBED3 -0.49 -6.78 -0.38 7.77e-11 Asthma; CESC cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.94 0.34 9.15e-9 Colonoscopy-negative controls vs population controls; CESC cis rs174775 0.513 rs2283849 chr22:29743482 T/C cg07256473 chr22:29710276 RASL10A -0.48 -7.26 -0.41 4.39e-12 Immature fraction of reticulocytes; CESC cis rs7666738 0.830 rs7691433 chr4:98968118 A/T cg17366294 chr4:99064904 C4orf37 0.59 7.92 0.44 6.48e-14 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.948 rs72790326 chr2:24126153 C/T cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs34638657 0.797 rs11645045 chr16:82202137 G/A cg09439754 chr16:82129088 HSD17B2 -0.35 -5.68 -0.33 3.63e-8 Lung adenocarcinoma; CESC cis rs34638657 0.797 rs7203990 chr16:82185320 A/G cg09439754 chr16:82129088 HSD17B2 -0.34 -5.29 -0.31 2.54e-7 Lung adenocarcinoma; CESC cis rs7116495 0.541 rs579320 chr11:71794954 G/T cg10381502 chr11:71823885 C11orf51 -0.66 -5.4 -0.31 1.51e-7 Severe influenza A (H1N1) infection; CESC cis rs7666738 0.515 rs13142498 chr4:98792443 G/T cg05340658 chr4:99064831 C4orf37 0.54 6.59 0.38 2.39e-10 Colonoscopy-negative controls vs population controls; CESC cis rs870825 0.616 rs28497285 chr4:185629169 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs9790314 0.846 rs9834659 chr3:160980947 A/C cg03342759 chr3:160939853 NMD3 -0.51 -7.39 -0.41 1.96e-12 Morning vs. evening chronotype; CESC cis rs919433 0.750 rs788010 chr2:198230949 T/C cg03934865 chr2:198174659 NA 0.43 6.21 0.36 2.01e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2282802 0.635 rs199152 chr5:139539235 C/T cg26211634 chr5:139558579 C5orf32 -0.42 -5.77 -0.33 2.23e-8 Intelligence (multi-trait analysis); CESC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg05863683 chr7:1912471 MAD1L1 0.5 7.78 0.43 1.58e-13 Bipolar disorder and schizophrenia; CESC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg06505273 chr16:24850292 NA 0.53 6.49 0.37 4.27e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9457247 0.534 rs9347170 chr6:167405187 C/T cg23791538 chr6:167370224 RNASET2 0.68 9.94 0.52 5.5e-20 Crohn's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27261837 chr1:146714163 CHD1L -0.42 -6.11 -0.35 3.63e-9 Gambling; CESC cis rs11098499 0.731 rs10015579 chr4:120271802 T/C cg09307838 chr4:120376055 NA 0.77 10.31 0.54 3.49e-21 Corneal astigmatism; CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg05064044 chr6:292385 DUSP22 -0.66 -8.23 -0.45 8.7e-15 Menopause (age at onset); CESC cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg05535760 chr7:792225 HEATR2 -0.79 -8.61 -0.47 6.7e-16 Cerebrospinal P-tau181p levels; CESC cis rs12079745 0.793 rs3766082 chr1:169215068 A/T cg09363564 chr1:169337483 NME7;BLZF1 0.92 5.87 0.34 1.31e-8 QT interval; CESC cis rs12618769 0.652 rs6736755 chr2:99204428 A/G cg10123293 chr2:99228465 UNC50 -0.4 -5.27 -0.31 2.79e-7 Bipolar disorder; CESC cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg17971929 chr21:40555470 PSMG1 0.59 7.61 0.42 4.85e-13 Cognitive function; CESC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs1707322 0.752 rs3811435 chr1:46125790 C/A cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1178968 0.901 rs799303 chr7:72804412 A/C cg25889504 chr7:72793014 NA -0.53 -5.65 -0.33 4.18e-8 Triglyceride levels; CESC cis rs2262909 0.962 rs17459246 chr19:22278121 T/C cg11619707 chr19:22235551 ZNF257 0.35 5.76 0.33 2.38e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs9486715 0.838 rs7770889 chr6:96858453 C/T cg18709589 chr6:96969512 KIAA0776 -0.42 -6.03 -0.35 5.62e-9 Headache; CESC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg20607287 chr7:12443886 VWDE -0.7 -8.49 -0.46 1.46e-15 Coronary artery disease; CESC cis rs763014 0.898 rs8050792 chr16:656033 T/C cg07256732 chr16:621771 PIGQ -0.32 -5.54 -0.32 7.4e-8 Height; CESC cis rs10838687 0.669 rs830084 chr11:47251652 T/C cg25783544 chr11:47291846 MADD -0.57 -6.69 -0.38 1.3100000000000001e-10 Proinsulin levels; CESC cis rs1975974 0.872 rs17052352 chr17:21721972 A/G cg18423549 chr17:21743878 NA -0.52 -7.35 -0.41 2.47e-12 Psoriasis; CESC cis rs1879734 0.731 rs11206198 chr1:54165910 C/A cg23596471 chr1:54105337 GLIS1 0.35 5.58 0.32 5.97e-8 Mitral valve prolapse; CESC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg08536481 chr12:123459152 ABCB9;OGFOD2 0.46 6.18 0.35 2.42e-9 Bronchopulmonary dysplasia; CESC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg18876405 chr7:65276391 NA 0.45 6.04 0.35 5.11e-9 Calcium levels; CESC cis rs9790314 0.967 rs9821201 chr3:160996155 G/C cg03342759 chr3:160939853 NMD3 -0.45 -5.9 -0.34 1.08e-8 Morning vs. evening chronotype; CESC cis rs1348850 0.526 rs6718769 chr2:178450909 T/C cg22681709 chr2:178499509 PDE11A -0.46 -5.05 -0.3 8.22e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.36 -0.36 8.66e-10 Depression; CESC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.78 0.38 7.61e-11 Platelet count; CESC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg18876405 chr7:65276391 NA 0.51 6.0 0.35 6.35e-9 Aortic root size; CESC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg22920501 chr2:26401640 FAM59B 0.72 8.09 0.45 2.15e-14 Gut microbiome composition (summer); CESC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg08470875 chr2:26401718 FAM59B -0.67 -7.34 -0.41 2.59e-12 Gut microbiome composition (summer); CESC cis rs2710642 0.564 rs6752597 chr2:62823444 T/C cg17519650 chr2:63277830 OTX1 0.48 6.38 0.36 7.95e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.77 10.11 0.53 1.55e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs17431357 0.867 rs73225219 chr12:120953571 C/A cg25045489 chr12:120971538 RNF10 -0.93 -5.37 -0.31 1.76e-7 Insulin resistance/response; CESC cis rs67478160 0.595 rs12879501 chr14:104272634 G/T cg08213375 chr14:104286397 PPP1R13B 0.54 10.66 0.55 2.51e-22 Schizophrenia; CESC cis rs3740540 0.530 rs4297414 chr10:126292116 T/G cg04949429 chr10:126290192 LHPP 0.41 5.51 0.32 8.5e-8 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg03396347 chr1:1875803 NA -0.43 -6.69 -0.38 1.33e-10 Body mass index; CESC trans rs877282 1.000 rs11253370 chr10:773712 G/A cg22713356 chr15:30763199 NA 1.12 11.27 0.57 2.42e-24 Uric acid levels; CESC cis rs6088580 0.634 rs6120669 chr20:33105028 T/C cg24642439 chr20:33292090 TP53INP2 0.5 6.57 0.37 2.61e-10 Glomerular filtration rate (creatinine); CESC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg24690094 chr11:67383802 NA 0.41 7.01 0.4 1.94e-11 Mean corpuscular volume; CESC cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg21573476 chr21:45109991 RRP1B -0.58 -8.36 -0.46 3.54e-15 Mean corpuscular volume; CESC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.86 0.43 9.54e-14 Prudent dietary pattern; CESC cis rs3768617 0.510 rs10797846 chr1:183087485 A/T ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.49e-35 Fuchs's corneal dystrophy; CESC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg13206674 chr6:150067644 NUP43 0.41 5.72 0.33 2.81e-8 Lung cancer; CESC cis rs4835473 0.932 rs4835476 chr4:144906670 T/G cg25736465 chr4:144833511 NA 0.41 6.29 0.36 1.28e-9 Immature fraction of reticulocytes; CESC cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.09 11.12 0.56 7.8e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.66 8.91 0.48 8.17e-17 Prudent dietary pattern; CESC cis rs2228479 0.850 rs11647174 chr16:89958538 G/A cg06558623 chr16:89946397 TCF25 1.17 9.37 0.5 3.29e-18 Skin colour saturation; CESC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg22549504 chr19:17448937 GTPBP3 0.52 5.88 0.34 1.24e-8 Systemic lupus erythematosus; CESC cis rs7845219 0.544 rs2123647 chr8:95931782 A/G cg13393036 chr8:95962371 TP53INP1 0.42 8.03 0.44 3.14e-14 Type 2 diabetes; CESC cis rs1348850 0.914 rs4893823 chr2:178285811 C/T cg23306229 chr2:178417860 TTC30B -0.67 -8.72 -0.47 3.11e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9287719 0.837 rs4233882 chr2:10755564 A/G cg00105475 chr2:10696890 NA 0.37 5.2 0.3 3.96e-7 Prostate cancer; CESC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg11764359 chr7:65958608 NA -0.79 -11.58 -0.58 2.22e-25 Aortic root size; CESC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg13206674 chr6:150067644 NUP43 0.43 6.15 0.35 2.83e-9 Lung cancer; CESC cis rs208520 0.954 rs72884027 chr6:66995044 T/G cg07460842 chr6:66804631 NA 0.88 9.99 0.52 3.87e-20 Exhaled nitric oxide output; CESC cis rs739401 0.527 rs423236 chr11:3065916 C/T cg08508325 chr11:3079039 CARS -0.54 -10.23 -0.53 6.21e-21 Longevity; CESC cis rs9486715 0.830 rs1475748 chr6:97034143 T/C cg06623918 chr6:96969491 KIAA0776 -0.95 -14.99 -0.68 3.24e-37 Headache; CESC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg00149659 chr3:10157352 C3orf10 0.72 8.61 0.47 6.41e-16 Alzheimer's disease; CESC cis rs13095912 0.889 rs6778977 chr3:185302532 T/G cg11274856 chr3:185301563 NA 0.37 6.02 0.35 5.91e-9 Systolic blood pressure; CESC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg24829409 chr8:58192753 C8orf71 -0.78 -10.21 -0.53 7.21e-21 Developmental language disorder (linguistic errors); CESC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg23048001 chr7:2026167 MAD1L1 0.42 5.38 0.31 1.62e-7 Bipolar disorder and schizophrenia; CESC cis rs116095464 0.558 rs2162870 chr5:228129 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.65 -0.47 5.2e-16 Breast cancer; CESC cis rs9831754 0.906 rs9840031 chr3:78396140 C/T cg06138941 chr3:78371609 NA 0.69 8.52 0.46 1.26e-15 Calcium levels; CESC cis rs2404602 0.735 rs2454454 chr15:76823647 A/G cg23625390 chr15:77176239 SCAPER -0.4 -5.69 -0.33 3.31e-8 Blood metabolite levels; CESC cis rs4683142 0.518 rs7653682 chr3:46029271 A/G cg18004856 chr3:46029278 FYCO1 0.41 5.61 0.33 5.07e-8 Methadone dose in opioid dependence; CESC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg05234568 chr11:5960015 NA -0.66 -9.96 -0.52 4.63e-20 DNA methylation (variation); CESC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg25072359 chr17:41440525 NA 0.49 6.41 0.37 6.64e-10 Menopause (age at onset); CESC cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2354432 0.556 rs34602039 chr1:146850972 G/A cg25205988 chr1:146714368 CHD1L -1.07 -9.01 -0.48 4.13e-17 Mitochondrial DNA levels; CESC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg26335602 chr6:28129616 ZNF389 0.48 6.07 0.35 4.39e-9 Parkinson's disease; CESC cis rs4072980 0.545 rs12120737 chr1:38422544 C/T cg12658694 chr1:38397304 INPP5B 0.65 8.98 0.48 5e-17 Coronary artery disease; CESC cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.18 0.3 4.42e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg13114125 chr14:105738426 BRF1 -0.8 -9.72 -0.51 2.68e-19 Mean platelet volume;Platelet distribution width; CESC cis rs2952156 0.920 rs1476278 chr17:37836243 C/T cg07936489 chr17:37558343 FBXL20 -0.6 -7.98 -0.44 4.39e-14 Asthma; CESC cis rs2243480 1.000 rs56291018 chr7:65390339 G/A cg18252515 chr7:66147081 NA -1.18 -10.88 -0.56 5.02e-23 Diabetic kidney disease; CESC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg06481639 chr22:41940642 POLR3H -0.6 -6.28 -0.36 1.35e-9 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24449463 chr1:168025552 DCAF6 -0.66 -7.71 -0.43 2.47e-13 Gut microbiome composition (summer); CESC cis rs561341 0.556 rs542244 chr17:30307242 T/C cg00745463 chr17:30367425 LRRC37B -0.78 -7.07 -0.4 1.39e-11 Hip circumference adjusted for BMI; CESC trans rs35110281 0.627 rs1436291 chr21:44965485 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 7.61 0.42 4.68e-13 Mean corpuscular volume; CESC cis rs7208859 0.623 rs7217984 chr17:29092766 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7100689 0.753 rs1856773 chr10:82060484 T/A cg00277334 chr10:82204260 NA -0.58 -7.31 -0.41 3.1e-12 Post bronchodilator FEV1; CESC cis rs6456156 0.792 rs4710179 chr6:167513692 G/T cg23791538 chr6:167370224 RNASET2 -0.39 -5.09 -0.3 6.69e-7 Primary biliary cholangitis; CESC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg00750074 chr16:89608354 SPG7 -0.46 -6.6 -0.38 2.2e-10 Multiple myeloma (IgH translocation); CESC cis rs1843834 0.898 rs2014887 chr2:225520082 A/G cg22455342 chr2:225449267 CUL3 0.52 6.56 0.37 2.79e-10 IgE levels in asthmatics (D.p. specific); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12951224 chr8:38126910 PPAPDC1B 0.49 6.32 0.36 1.13e-9 Gut microbiota (bacterial taxa); CESC cis rs1878931 0.520 rs2015640 chr16:3465018 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.74 -8.58 -0.47 8.04e-16 Body mass index (adult); CESC cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.59 5.69 0.33 3.44e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9549367 0.789 rs71446682 chr13:113894908 A/G cg00898013 chr13:113819073 PROZ -0.51 -6.94 -0.39 3.06e-11 Platelet distribution width; CESC cis rs6831352 0.918 rs4699714 chr4:100060538 A/G cg12011299 chr4:100065546 ADH4 -0.59 -6.59 -0.38 2.35e-10 Alcohol dependence; CESC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg18876405 chr7:65276391 NA -0.57 -7.55 -0.42 6.85e-13 Aortic root size; CESC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg11859384 chr17:80120422 CCDC57 0.38 5.08 0.3 7.27e-7 Life satisfaction; CESC cis rs1322639 0.614 rs6925950 chr6:169563958 A/G cg04662567 chr6:169592167 NA -0.5 -5.26 -0.31 2.93e-7 Pulse pressure; CESC cis rs6973256 0.583 rs2345943 chr7:133340630 A/G cg10665199 chr7:133106180 EXOC4 -0.48 -6.6 -0.38 2.18e-10 Intelligence (multi-trait analysis); CESC cis rs1670533 1.000 rs2045066 chr4:1052401 C/T cg04106633 chr4:1044584 NA 0.4 5.27 0.31 2.81e-7 Recombination rate (females); CESC cis rs4595586 0.545 rs61939643 chr12:39378460 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03970961 chr1:154292240 AQP10 -0.54 -7.47 -0.42 1.2e-12 Gut microbiome composition (summer); CESC cis rs7589342 0.628 rs11886675 chr2:106409118 G/T cg16077055 chr2:106428750 NCK2 0.54 6.84 0.39 5.44e-11 Addiction; CESC cis rs854765 0.583 rs8075965 chr17:17853180 A/T cg04398451 chr17:18023971 MYO15A -0.69 -9.86 -0.52 9.76e-20 Total body bone mineral density; CESC cis rs5753618 0.583 rs2273251 chr22:31843567 G/C cg02404636 chr22:31891804 SFI1 0.4 5.43 0.32 1.3e-7 Colorectal cancer; CESC cis rs3925075 1.000 rs4889543 chr16:31340216 C/T cg02846316 chr16:31340340 ITGAM 0.43 6.68 0.38 1.41e-10 IgA nephropathy; CESC cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.39 -6.75 -0.38 9.31e-11 Hemoglobin concentration; CESC cis rs7937682 0.562 rs519850 chr11:111376888 A/T cg09085632 chr11:111637200 PPP2R1B -0.64 -8.59 -0.47 7.45e-16 Primary sclerosing cholangitis; CESC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -0.88 -12.58 -0.61 9.2e-29 Alzheimer's disease; CESC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg16049864 chr8:95962084 TP53INP1 0.64 10.1 0.53 1.72e-20 Type 2 diabetes; CESC cis rs1707322 1.000 rs1707317 chr1:46510642 C/T cg06784218 chr1:46089804 CCDC17 -0.35 -5.96 -0.34 7.81e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12500824 0.564 rs62303261 chr4:77286929 C/T cg20311846 chr4:77356250 SHROOM3 0.37 6.68 0.38 1.41e-10 Coronary artery disease; CESC cis rs6662572 0.737 rs9429184 chr1:46524739 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.12 0.3 5.86e-7 Blood protein levels; CESC cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.33 -5.07 -0.3 7.65e-7 Platelet count; CESC cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg17211192 chr8:82754475 SNX16 -0.58 -7.38 -0.41 2.05e-12 Diastolic blood pressure; CESC cis rs7188697 0.882 rs37054 chr16:58558989 C/T cg02549819 chr16:58548995 SETD6 -0.42 -5.23 -0.31 3.45e-7 QT interval; CESC cis rs11608355 0.515 rs7310945 chr12:109946012 G/A cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs7923609 0.967 rs7085621 chr10:65208926 T/C cg01631684 chr10:65280961 REEP3 -0.43 -5.39 -0.31 1.55e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs11608355 0.515 rs7311488 chr12:109930905 C/G cg05360138 chr12:110035743 NA -0.79 -8.46 -0.46 1.85e-15 Neuroticism; CESC cis rs10214930 0.671 rs7799957 chr7:27882260 A/G cg05786569 chr7:27702416 HIBADH 0.45 5.46 0.32 1.08e-7 Hypospadias; CESC cis rs959260 0.925 rs9747801 chr17:73396572 C/T cg12999837 chr17:73267436 MIF4GD -0.48 -5.52 -0.32 8.2e-8 Systemic lupus erythematosus; CESC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.17 -0.53 9.95e-21 Alzheimer's disease; CESC cis rs1348850 0.958 rs1545364 chr2:178462882 G/T cg22681709 chr2:178499509 PDE11A -0.34 -5.16 -0.3 4.86e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -8.85 -0.48 1.32e-16 Mean corpuscular volume; CESC cis rs965513 1.000 rs7028661 chr9:100538470 A/G cg13688889 chr9:100608707 NA -0.6 -8.47 -0.46 1.71e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs1670533 1.000 rs6850784 chr4:1059809 G/A cg04106633 chr4:1044584 NA 0.4 5.19 0.3 4.15e-7 Recombination rate (females); CESC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg22800045 chr5:56110881 MAP3K1 0.82 10.18 0.53 9.04e-21 Initial pursuit acceleration; CESC cis rs7635838 0.859 rs9812885 chr3:11508326 G/C cg00170343 chr3:11313890 ATG7 0.42 5.64 0.33 4.38e-8 HDL cholesterol; CESC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.01 9.83 0.52 1.21e-19 Platelet count; CESC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg11965913 chr1:205819406 PM20D1 0.76 11.83 0.59 3.37e-26 Menarche (age at onset); CESC cis rs9916302 0.706 rs3744349 chr17:37414842 C/T cg07936489 chr17:37558343 FBXL20 -0.87 -9.31 -0.5 5.09e-18 Glomerular filtration rate (creatinine); CESC cis rs2228479 0.850 rs1108063 chr16:89893983 A/G cg04013166 chr16:89971882 TCF25 0.67 5.46 0.32 1.08e-7 Skin colour saturation; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg08971769 chr10:75258327 USP54 -0.49 -6.37 -0.36 8.19e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs10927875 0.632 rs2862162 chr1:16142960 A/C cg05821634 chr1:16164109 FLJ37453 -0.35 -5.17 -0.3 4.72e-7 Dilated cardiomyopathy; CESC cis rs6580649 0.941 rs3742074 chr12:48457385 C/T cg05342945 chr12:48394962 COL2A1 0.5 5.85 0.34 1.47e-8 Lung cancer; CESC cis rs57221529 0.825 rs7443550 chr5:578404 G/T cg16447950 chr5:562315 NA -0.64 -6.81 -0.39 6.59e-11 Lung disease severity in cystic fibrosis; CESC cis rs9905704 0.645 rs17175543 chr17:56803598 G/T cg12560992 chr17:57184187 TRIM37 0.63 5.88 0.34 1.21e-8 Testicular germ cell tumor; CESC cis rs637571 0.522 rs566590 chr11:65754062 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.74 10.65 0.55 2.7e-22 Eosinophil percentage of white cells; CESC cis rs7833790 0.654 rs7835342 chr8:82698092 A/G cg07697082 chr8:82753677 SNX16 0.36 5.54 0.32 7.16e-8 Diastolic blood pressure; CESC trans rs11250098 0.541 rs6997997 chr8:10766082 T/C cg15556689 chr8:8085844 FLJ10661 -0.54 -6.26 -0.36 1.55e-9 Morning vs. evening chronotype; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg02872018 chr2:192746213 NA -0.46 -6.57 -0.37 2.6200000000000003e-10 Thyroid stimulating hormone; CESC cis rs9611565 0.592 rs28750375 chr22:41990644 A/C cg06634786 chr22:41940651 POLR3H -0.57 -6.24 -0.36 1.69e-9 Vitiligo; CESC trans rs10242455 0.571 rs45532337 chr7:99310319 A/G cg09045935 chr12:6379348 NA 0.73 6.54 0.37 3.14e-10 Blood metabolite levels; CESC cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg16240275 chr20:61666158 NCRNA00029 0.51 9.07 0.49 2.84e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg00078996 chr12:132293329 NA -0.45 -5.99 -0.35 6.77e-9 Migraine; CESC cis rs7225151 0.518 rs56176579 chr17:5262253 C/T cg24500398 chr17:5266808 RABEP1 -0.55 -6.69 -0.38 1.36e-10 Alzheimer's disease (late onset); CESC cis rs60843830 1.000 rs11553746 chr2:272203 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.89 11.92 0.59 1.67e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs225245 0.817 rs225297 chr17:33924587 G/A cg05299278 chr17:33885742 SLFN14 0.38 5.46 0.32 1.08e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs1215050 0.740 rs783938 chr4:99010336 A/T cg05340658 chr4:99064831 C4orf37 -0.53 -7.17 -0.4 7.67e-12 Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16759888 chr6:46620647 CYP39A1;SLC25A27 0.56 6.01 0.35 6.24e-9 Gut microbiome composition (summer); CESC cis rs447735 0.566 rs258337 chr16:89720710 T/A cg03605463 chr16:89740564 NA 0.43 5.31 0.31 2.3e-7 Hemoglobin concentration; CESC cis rs5769707 0.846 rs5770610 chr22:50036897 A/C cg05373962 chr22:49881684 NA -0.4 -6.91 -0.39 3.65e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs7116495 0.737 rs661290 chr11:71766014 A/G cg07596299 chr11:71824057 C11orf51 -0.85 -5.29 -0.31 2.51e-7 Severe influenza A (H1N1) infection; CESC cis rs9399137 0.507 rs13196486 chr6:135283874 C/G cg22676075 chr6:135203613 NA 0.53 7.0 0.39 2.14e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs8114671 0.805 rs4616 chr20:33590358 C/T cg06115741 chr20:33292138 TP53INP2 -0.46 -5.53 -0.32 7.8e-8 Height; CESC cis rs67478160 0.595 rs12889993 chr14:104274294 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.19 -0.4 6.56e-12 Schizophrenia; CESC cis rs1843834 0.688 rs2396149 chr2:225601985 G/A cg22455342 chr2:225449267 CUL3 0.4 5.19 0.3 4.22e-7 IgE levels in asthmatics (D.p. specific); CESC cis rs11030122 0.661 rs10835561 chr11:4087594 C/T cg18678763 chr11:4115507 RRM1 -0.47 -6.39 -0.37 7.47e-10 Mean platelet volume;Platelet distribution width; CESC cis rs17253792 0.822 rs10083431 chr14:56068348 G/A cg01858014 chr14:56050164 KTN1 -0.83 -7.03 -0.4 1.7e-11 Putamen volume; CESC cis rs5758511 0.514 rs9607882 chr22:42567451 A/G cg00645731 chr22:42541494 CYP2D7P1 0.59 8.74 0.47 2.7e-16 Birth weight; CESC cis rs3105593 1.000 rs11070798 chr15:50883263 T/C cg08437265 chr15:50716283 USP8 0.42 5.49 0.32 9.52e-8 QT interval; CESC cis rs7216064 0.684 rs7406031 chr17:66021753 C/T cg07042672 chr17:66097459 LOC651250 0.63 8.27 0.45 6.65e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7553864 0.614 rs1886634 chr1:87614821 C/T cg17420885 chr1:87600446 LOC339524 0.46 6.19 0.36 2.3e-9 Smoking behavior; CESC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.11 -21.97 -0.8 1.23e-61 Prudent dietary pattern; CESC cis rs910316 0.763 rs6574205 chr14:75453039 G/C cg11812906 chr14:75593930 NEK9 0.8 12.79 0.62 1.77e-29 Height; CESC cis rs9916302 0.784 rs4795382 chr17:37700860 A/G cg15445000 chr17:37608096 MED1 0.42 6.91 0.39 3.53e-11 Glomerular filtration rate (creatinine); CESC cis rs6736093 0.796 rs4848980 chr2:112816348 A/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.63 -0.33 4.68e-8 Coronary artery disease; CESC cis rs1707322 0.721 rs10890346 chr1:46223892 C/T cg05343316 chr1:45956843 TESK2 -0.48 -6.01 -0.35 6.23e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg10691866 chr7:65817282 TPST1 -0.33 -5.42 -0.32 1.34e-7 Aortic root size; CESC cis rs7086627 0.515 rs10887899 chr10:82210214 G/A cg00277334 chr10:82204260 NA -0.9 -15.67 -0.69 1.3e-39 Post bronchodilator FEV1; CESC cis rs1348850 0.574 rs10195917 chr2:178443121 C/T cg22681709 chr2:178499509 PDE11A -0.43 -5.36 -0.31 1.79e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10870270 1.000 rs4880250 chr10:133773919 G/A cg08754478 chr10:133766260 PPP2R2D -0.58 -7.47 -0.42 1.14e-12 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7666738 0.791 rs13146909 chr4:98934198 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7129220 0.588 rs16907481 chr11:10144108 A/T cg01453529 chr11:10209919 SBF2 -0.43 -5.22 -0.31 3.65e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08755283 chr5:118324104 DTWD2 0.6 7.32 0.41 3.03e-12 Gut microbiome composition (summer); CESC cis rs7267979 1.000 rs6115168 chr20:25372891 C/A cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.83e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22333016 chr4:54244258 FIP1L1 -0.49 -6.41 -0.37 6.79e-10 Ulcerative colitis; CESC cis rs2295359 1.000 rs10889664 chr1:67635475 C/T cg03340356 chr1:67600835 NA 0.34 5.4 0.31 1.47e-7 Psoriasis; CESC cis rs2276314 1.000 rs16967317 chr18:33573400 A/G cg05985134 chr18:33552581 C18orf21 0.64 7.39 0.41 1.9e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.02e-11 Tonsillectomy; CESC cis rs4835473 0.932 rs35055653 chr4:144675989 C/T cg25736465 chr4:144833511 NA -0.43 -6.5 -0.37 4.01e-10 Immature fraction of reticulocytes; CESC cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg10523679 chr1:76189770 ACADM 0.68 6.31 0.36 1.18e-9 Blood metabolite levels;Acylcarnitine levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05671585 chr4:186064123 SLC25A4 -0.52 -6.23 -0.36 1.79e-9 Ulcerative colitis; CESC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg03576123 chr11:487126 PTDSS2 -1.1 -11.01 -0.56 1.79e-23 Body mass index; CESC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg07343612 chr16:622815 PIGQ -0.57 -8.34 -0.46 4.2e-15 Height; CESC cis rs72781680 1.000 rs72796329 chr2:24141912 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs6499255 0.904 rs9929720 chr16:69557096 C/T cg15192750 chr16:69999425 NA -0.54 -6.29 -0.36 1.31e-9 IgE levels; CESC cis rs2250402 0.510 rs2291619 chr15:40329033 C/T cg20255370 chr15:40268687 EIF2AK4 0.61 5.61 0.33 5.05e-8 Corneal curvature; CESC cis rs2243480 1.000 rs2533288 chr7:66056711 C/G cg12463550 chr7:65579703 CRCP 0.72 5.62 0.33 4.87e-8 Diabetic kidney disease; CESC cis rs6489785 0.735 rs12825746 chr12:121268033 A/C cg02419362 chr12:121203948 SPPL3 0.35 5.52 0.32 8.19e-8 Longevity;Allergic disease (asthma, hay fever or eczema); CESC cis rs72781680 0.898 rs55846516 chr2:24158003 T/C cg20701182 chr2:24300061 SF3B14 0.65 5.81 0.34 1.79e-8 Lymphocyte counts; CESC cis rs2299587 0.554 rs17634704 chr8:17753306 A/G cg08627089 chr8:17753878 FGL1 -0.39 -5.65 -0.33 4.15e-8 Economic and political preferences; CESC cis rs12142240 0.698 rs66516678 chr1:46810112 G/T cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs4450798 0.649 rs61179105 chr3:13791319 C/T cg23332027 chr3:13681764 NA 0.38 5.13 0.3 5.63e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg02462569 chr6:150064036 NUP43 -0.39 -5.74 -0.33 2.52e-8 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08403428 chr12:124899777 NCOR2 0.51 6.87 0.39 4.52e-11 Fibrinogen levels; CESC cis rs7524258 0.900 rs2412151 chr1:7303216 G/C cg07173049 chr1:7289937 CAMTA1 0.37 5.62 0.33 4.8e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs72634258 0.699 rs12128234 chr1:8170219 T/C cg00042356 chr1:8021962 PARK7 -0.56 -5.99 -0.35 6.97e-9 Inflammatory bowel disease; CESC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg04414720 chr1:150670196 GOLPH3L 0.57 7.68 0.43 3.18e-13 Melanoma; CESC cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.5 0.32 9.09e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6582630 0.555 rs34884627 chr12:38443831 C/T cg26384229 chr12:38710491 ALG10B -0.44 -5.95 -0.34 8.28e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs6032067 1.000 rs6032067 chr20:43864809 G/T cg10761708 chr20:43804764 PI3 0.52 6.26 0.36 1.52e-9 Blood protein levels; CESC cis rs2797160 1.000 rs9321050 chr6:126001568 A/G cg05901451 chr6:126070800 HEY2 -0.46 -6.64 -0.38 1.76e-10 Endometrial cancer; CESC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg07701084 chr6:150067640 NUP43 0.4 5.49 0.32 9.18e-8 Lung cancer; CESC cis rs17641971 0.684 rs4873095 chr8:49990166 A/T cg00325661 chr8:49890786 NA 0.39 5.5 0.32 8.94e-8 Blood metabolite levels; CESC cis rs12545109 0.800 rs1440762 chr8:57410708 C/T cg09654669 chr8:57350985 NA -0.47 -6.5 -0.37 4.05e-10 Obesity-related traits; CESC cis rs7851660 0.901 rs2401639 chr9:100607837 T/C cg13688889 chr9:100608707 NA -0.68 -10.61 -0.55 3.8e-22 Strep throat; CESC trans rs561341 1.000 rs4795670 chr17:30244839 T/C cg27661571 chr11:113659931 NA -0.62 -6.6 -0.38 2.27e-10 Hip circumference adjusted for BMI; CESC cis rs9908102 0.740 rs60875833 chr17:12912789 T/G cg26162695 chr17:12921313 ELAC2 0.52 5.71 0.33 3.04e-8 Schizophrenia; CESC cis rs6547741 1.000 rs6547740 chr2:27854369 C/T cg21248554 chr2:27665150 KRTCAP3 0.24 5.1 0.3 6.55e-7 Oral cavity cancer; CESC trans rs1814175 0.618 rs1851843 chr11:50021846 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -6.13 -0.35 3.1e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05593479 chr2:233415006 TIGD1;EIF4E2 -0.61 -7.52 -0.42 8.54e-13 Gut microbiome composition (summer); CESC trans rs1814175 0.619 rs10769623 chr11:49865926 C/T cg11707556 chr5:10655725 ANKRD33B -0.41 -6.15 -0.35 2.81e-9 Height; CESC trans rs11039798 0.565 rs7118675 chr11:48532063 C/A cg03929089 chr4:120376271 NA 0.61 6.02 0.35 5.81e-9 Axial length; CESC cis rs76878669 0.561 rs7948058 chr11:66148111 T/A cg18002602 chr11:66138449 SLC29A2 -0.41 -6.76 -0.38 8.55e-11 Educational attainment (years of education); CESC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg18252515 chr7:66147081 NA -0.47 -6.08 -0.35 4.25e-9 Aortic root size; CESC cis rs4716602 0.827 rs10270019 chr7:156158973 T/C cg04090468 chr7:156181990 NA 0.4 5.15 0.3 5.18e-7 Anti-saccade response; CESC cis rs1062177 0.826 rs2053063 chr5:151166764 T/C cg12924095 chr5:151150029 G3BP1 0.45 5.97 0.34 7.43e-9 Preschool internalizing problems; CESC trans rs17181170 0.523 rs62257771 chr3:87208290 C/T ch.2.199792288R chr2:200084043 NA -0.46 -6.1 -0.35 3.78e-9 Prostate cancer; CESC cis rs6061231 0.544 rs2427314 chr20:60973666 C/T cg22633769 chr20:60982531 CABLES2 0.71 9.11 0.49 2.04e-17 Colorectal cancer; CESC cis rs2075371 0.796 rs1646644 chr7:134011817 A/T cg00033643 chr7:134001901 SLC35B4 0.41 5.1 0.3 6.33e-7 Mean platelet volume; CESC cis rs4481887 0.604 rs4430368 chr1:248411573 A/G cg00666640 chr1:248458726 OR2T12 0.42 6.45 0.37 5.31e-10 Common traits (Other); CESC cis rs9359856 0.564 rs11961752 chr6:90481896 T/C cg13799429 chr6:90582589 CASP8AP2 -0.64 -6.06 -0.35 4.56e-9 Bipolar disorder; CESC cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg00825309 chr19:58991885 ZNF446 -0.55 -7.86 -0.43 9.42e-14 Uric acid clearance; CESC cis rs6831352 0.918 rs2851248 chr4:100045974 A/G cg13256891 chr4:100009986 ADH5 0.65 7.2 0.4 6.26e-12 Alcohol dependence; CESC cis rs9796 0.649 rs8035828 chr15:41467287 T/A cg18705301 chr15:41695430 NDUFAF1 -0.44 -6.42 -0.37 6.29e-10 Menopause (age at onset); CESC cis rs709400 0.663 rs62007684 chr14:103894223 T/C cg12935359 chr14:103987150 CKB -0.56 -8.22 -0.45 8.94e-15 Body mass index; CESC cis rs4253772 0.591 rs10854854 chr22:46684706 C/G cg18190219 chr22:46762943 CELSR1 -0.51 -5.53 -0.32 7.6e-8 LDL cholesterol;Cholesterol, total; CESC cis rs2425143 1.000 rs2425143 chr20:34350666 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.96 -0.44 5.07e-14 Blood protein levels; CESC cis rs3858526 0.635 rs2045046 chr11:5875867 A/C cg13902645 chr11:5959945 NA -0.53 -5.7 -0.33 3.17e-8 DNA methylation (variation); CESC cis rs2070488 0.965 rs1065800 chr3:38566480 C/T cg24069376 chr3:38537580 EXOG -0.45 -8.36 -0.46 3.55e-15 Electrocardiographic conduction measures; CESC cis rs9303280 0.901 rs869402 chr17:38068043 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.54 -0.32 7.27e-8 Self-reported allergy; CESC cis rs116095464 0.558 rs112343653 chr5:257174 G/A cg20965017 chr5:231967 SDHA -0.47 -5.22 -0.31 3.61e-7 Breast cancer; CESC cis rs74781061 0.929 rs4887159 chr15:74865882 G/A cg17294928 chr15:75287854 SCAMP5 -0.48 -5.15 -0.3 5.01e-7 Endometriosis; CESC cis rs2230307 0.536 rs534252 chr1:100472604 A/G cg24955406 chr1:100503596 HIAT1 0.55 5.48 0.32 9.85e-8 Carotid intima media thickness; CESC trans rs12936587 0.538 rs1869771 chr17:17561094 C/A cg00642494 chr5:76941749 NA -0.41 -6.16 -0.35 2.71e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CESC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg12311346 chr5:56204834 C5orf35 -0.74 -9.03 -0.49 3.59e-17 Initial pursuit acceleration; CESC cis rs4843747 0.641 rs11117353 chr16:88090895 A/G cg06915872 chr16:87998081 BANP 0.46 5.54 0.32 7.21e-8 Menopause (age at onset); CESC cis rs703842 0.616 rs4760171 chr12:58225904 A/G cg02175503 chr12:58329896 NA 0.46 5.85 0.34 1.42e-8 Multiple sclerosis; CESC cis rs7659604 0.702 rs6815790 chr4:122695385 A/C cg20573242 chr4:122745356 CCNA2 0.51 6.31 0.36 1.15e-9 Type 2 diabetes; CESC cis rs4699052 0.590 rs1356293 chr4:104288200 A/C cg16532752 chr4:104119610 CENPE -0.39 -5.49 -0.32 9.52e-8 Testicular germ cell tumor; CESC cis rs6942756 0.713 rs691807 chr7:129076203 G/C cg02491457 chr7:128862824 NA -0.57 -7.67 -0.43 3.28e-13 White matter hyperintensity burden; CESC cis rs7503807 0.967 rs12947696 chr17:78596793 C/T cg09596252 chr17:78655493 RPTOR 0.52 7.69 0.43 2.93e-13 Obesity; CESC cis rs7605827 0.930 rs7568874 chr2:15546361 T/C cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.45e-9 Educational attainment (years of education); CESC cis rs870825 0.655 rs28661636 chr4:185634218 A/C cg04058563 chr4:185651563 MLF1IP 0.63 6.89 0.39 3.95e-11 Blood protein levels; CESC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg11644478 chr21:40555479 PSMG1 0.99 14.37 0.66 4.94e-35 Cognitive function; CESC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg08859206 chr1:53392774 SCP2 -0.56 -7.37 -0.41 2.2e-12 Monocyte count; CESC cis rs9325144 0.647 rs7316392 chr12:39064381 T/G cg26384229 chr12:38710491 ALG10B -0.51 -7.09 -0.4 1.22e-11 Morning vs. evening chronotype; CESC cis rs731174 0.802 rs579908 chr1:38187447 A/G cg12339802 chr1:38156545 C1orf109 -0.56 -5.68 -0.33 3.52e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg20503657 chr10:835505 NA 0.74 6.75 0.38 9.51e-11 Eosinophil percentage of granulocytes; CESC cis rs7917772 0.503 rs11191326 chr10:104302959 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.49 0.42 9.98e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2404602 0.647 rs35940181 chr15:77180019 G/A cg23625390 chr15:77176239 SCAPER -0.44 -6.04 -0.35 5.32e-9 Blood metabolite levels; CESC cis rs7264396 0.563 rs2425136 chr20:34344782 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.9 -10.85 -0.55 6.29e-23 Total cholesterol levels; CESC cis rs17854409 0.803 rs1063246 chr20:61472116 G/A cg05147244 chr20:61493195 TCFL5 0.96 6.44 0.37 5.65e-10 Obesity-related traits; CESC cis rs2273669 0.667 rs11153153 chr6:109356104 A/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.06 -0.35 4.74e-9 Prostate cancer; CESC cis rs763121 0.853 rs5757253 chr22:39104320 C/T cg06544989 chr22:39130855 UNC84B 0.51 9.77 0.51 1.9e-19 Menopause (age at onset); CESC cis rs8072100 0.701 rs8075566 chr17:45771037 G/A cg08085267 chr17:45401833 C17orf57 -0.42 -5.31 -0.31 2.33e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs962856 0.575 rs3770655 chr2:67632125 C/T cg09028215 chr2:67624308 ETAA1 -0.43 -5.27 -0.31 2.86e-7 Pancreatic cancer; CESC cis rs9790314 1.000 rs336569 chr3:161072346 T/G cg03342759 chr3:160939853 NMD3 -0.47 -6.3 -0.36 1.26e-9 Morning vs. evening chronotype; CESC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg18479299 chr3:125709523 NA -0.47 -5.05 -0.3 8.2e-7 Blood pressure (smoking interaction); CESC cis rs1577917 1.000 rs1415753 chr6:86753074 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.85 -0.34 1.47e-8 Response to antipsychotic treatment; CESC cis rs6439153 0.933 rs2630262 chr3:128677098 C/T cg25356066 chr3:128598488 ACAD9 -0.51 -6.86 -0.39 4.74e-11 Pneumococcal bacteremia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02570054 chr12:49717017 TROAP 0.5 6.4 0.37 7.15e-10 Gut microbiota (bacterial taxa); CESC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.64 0.64 1.84e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg15383120 chr6:291909 DUSP22 -0.67 -8.61 -0.47 6.67e-16 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13625205 chr1:151584902 SNX27 0.58 7.12 0.4 1.03e-11 Gut microbiome composition (summer); CESC cis rs2735413 0.918 rs12931394 chr16:78081629 G/A cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs1801251 0.929 rs12694917 chr2:233707611 C/T cg08000102 chr2:233561755 GIGYF2 -0.67 -9.8 -0.52 1.45e-19 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09360458 chr1:14075560 PRDM2 -0.54 -7.57 -0.42 6.04e-13 Gut microbiota (bacterial taxa); CESC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg25767906 chr1:53392781 SCP2 0.43 6.06 0.35 4.75e-9 Monocyte count; CESC trans rs1814175 0.645 rs7952104 chr11:49964180 C/T cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs919433 0.783 rs3097383 chr2:198236887 A/G cg03934865 chr2:198174659 NA 0.43 6.21 0.36 2.01e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs116095464 0.558 rs55664502 chr5:270485 T/C cg20965017 chr5:231967 SDHA -0.45 -5.14 -0.3 5.34e-7 Breast cancer; CESC cis rs2236918 0.664 rs1776158 chr1:242017658 C/T cg17736920 chr1:242011382 EXO1 0.52 6.68 0.38 1.4e-10 Menopause (age at onset); CESC cis rs35955747 0.869 rs8142988 chr22:31587158 T/C cg25791279 chr22:32026902 PISD -0.41 -5.11 -0.3 6.14e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs826838 1.000 rs11183941 chr12:38851692 G/C cg26384229 chr12:38710491 ALG10B 0.83 14.57 0.67 1.05e-35 Heart rate; CESC cis rs6570726 0.818 rs9399555 chr6:145877554 T/C cg23711669 chr6:146136114 FBXO30 0.87 12.91 0.62 6.56e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs113835537 0.529 rs57634456 chr11:66250838 A/C cg24851651 chr11:66362959 CCS 0.44 5.51 0.32 8.41e-8 Airway imaging phenotypes; CESC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Tonsillectomy; CESC cis rs7714584 1.000 rs73282209 chr5:150174959 G/A cg22134413 chr5:150180641 NA 0.66 6.54 0.37 3.09e-10 Crohn's disease; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg06213876 chr16:16357187 NOMO3 0.48 6.09 0.35 4.01e-9 Thyroid stimulating hormone; CESC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg21433313 chr16:3507492 NAT15 0.5 8.02 0.44 3.5e-14 Tuberculosis; CESC cis rs7520050 0.966 rs12561806 chr1:46396776 C/T cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.64e-8 Red blood cell count;Reticulocyte count; CESC cis rs933688 1.000 rs12656350 chr5:90751343 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.9 10.12 0.53 1.41e-20 Smoking behavior; CESC cis rs11696501 0.739 rs6104249 chr20:44250487 C/G cg11783356 chr20:44313418 WFDC10B 0.33 5.27 0.31 2.88e-7 Brain structure; CESC trans rs8057939 0.593 rs11860353 chr16:49409253 A/T cg15532236 chr6:170188124 NA 0.5 6.1 0.35 3.75e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs11098499 0.691 rs10010355 chr4:120261043 A/G cg25214090 chr10:38739885 LOC399744 0.61 8.68 0.47 4.06e-16 Corneal astigmatism; CESC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg17724175 chr1:150552817 MCL1 0.44 7.23 0.41 5.25e-12 Tonsillectomy; CESC cis rs9611565 0.729 rs137831 chr22:41903813 A/C cg06634786 chr22:41940651 POLR3H -0.5 -5.71 -0.33 2.99e-8 Vitiligo; CESC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg00166722 chr3:10149974 C3orf24 0.46 5.88 0.34 1.21e-8 Alzheimer's disease; CESC cis rs1270639 0.778 rs2906933 chr7:157450749 T/A cg13357408 chr7:157437802 PTPRN2 0.6 6.65 0.38 1.7e-10 Colorectal cancer; CESC cis rs4523957 0.651 rs7214741 chr17:2085598 C/T cg16513277 chr17:2031491 SMG6 -0.69 -9.74 -0.51 2.3e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs3820928 0.874 rs7582251 chr2:227791703 G/T cg11843606 chr2:227700838 RHBDD1 -0.44 -5.87 -0.34 1.29e-8 Pulmonary function; CESC cis rs9911578 1.000 rs1472288 chr17:56910720 G/A cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis); CESC cis rs7216064 1.000 rs62084248 chr17:65874541 C/T cg12091567 chr17:66097778 LOC651250 -0.86 -8.82 -0.48 1.55e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg07507251 chr3:52567010 NT5DC2 0.33 5.39 0.31 1.58e-7 Bipolar disorder; CESC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg03934478 chr11:495069 RNH1 0.56 5.39 0.31 1.54e-7 Body mass index; CESC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg06221963 chr1:154839813 KCNN3 -0.71 -11.86 -0.59 2.58e-26 Prostate cancer; CESC cis rs2880765 0.805 rs11858817 chr15:86031260 C/T cg19183879 chr15:85880815 NA -0.25 -5.26 -0.31 3.03e-7 Coronary artery disease; CESC cis rs371025208 1 rs371025208 chr20:43928602 TGGGTGTGTGTGTGTAGGG/T cg10761708 chr20:43804764 PI3 0.46 5.81 0.34 1.76e-8 Parental longevity (mother's age at death); CESC cis rs3793683 0.571 rs12781152 chr10:134590257 G/C cg26818010 chr10:134567672 INPP5A -0.91 -11.2 -0.57 4.4e-24 Migraine; CESC cis rs11785400 0.928 rs750529 chr8:143744877 G/C cg10596483 chr8:143751796 JRK 0.43 5.68 0.33 3.47e-8 Schizophrenia; CESC cis rs3096299 0.933 rs3114848 chr16:89452771 G/A cg02187348 chr16:89574699 SPG7 0.52 6.86 0.39 4.88e-11 Multiple myeloma (IgH translocation); CESC cis rs67311347 0.955 rs4974067 chr3:40374551 C/T cg24209194 chr3:40518798 ZNF619 0.4 5.24 0.31 3.29e-7 Renal cell carcinoma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10715820 chr1:17235063 NA 0.46 6.51 0.37 3.85e-10 Fibrinogen levels; CESC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg12463550 chr7:65579703 CRCP -0.6 -7.4 -0.41 1.78e-12 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07277624 chr20:44035142 DBNDD2;SYS1-DBNDD2 0.59 6.76 0.38 8.68e-11 Gut microbiome composition (summer); CESC cis rs11098499 0.909 rs6842762 chr4:120398236 A/T cg24375607 chr4:120327624 NA 0.45 5.67 0.33 3.64e-8 Corneal astigmatism; CESC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg24399712 chr22:39784796 NA -0.72 -10.59 -0.55 4.38e-22 Intelligence (multi-trait analysis); CESC cis rs6541297 0.938 rs7551742 chr1:230290118 A/G cg20703242 chr1:230279135 GALNT2 0.74 10.89 0.56 4.46e-23 Coronary artery disease; CESC cis rs910316 0.763 rs175057 chr14:75489632 C/T cg11812906 chr14:75593930 NEK9 -0.79 -12.22 -0.6 1.57e-27 Height; CESC cis rs11098499 0.863 rs58452170 chr4:120459674 A/T cg09307838 chr4:120376055 NA 0.9 12.15 0.6 2.72e-27 Corneal astigmatism; CESC cis rs9325144 0.560 rs11183189 chr12:38683770 T/A cg26384229 chr12:38710491 ALG10B 0.6 8.78 0.47 2e-16 Morning vs. evening chronotype; CESC cis rs4629710 0.592 rs11758994 chr6:131582022 A/C cg12606694 chr6:131520996 AKAP7 0.47 5.87 0.34 1.31e-8 Multiple myeloma (IgH translocation); CESC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC cis rs9467711 0.606 rs34878490 chr6:26370572 C/T cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC cis rs12479064 0.694 rs11896520 chr2:99995517 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.55 -6.51 -0.37 3.76e-10 Chronic sinus infection; CESC trans rs7615952 0.599 rs67566088 chr3:125768973 C/A cg07211511 chr3:129823064 LOC729375 -0.59 -6.53 -0.37 3.37e-10 Blood pressure (smoking interaction); CESC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.56 6.93 0.39 3.13e-11 Prudent dietary pattern; CESC cis rs9457247 0.612 rs2237273 chr6:167443017 T/C cg25258033 chr6:167368657 RNASET2 0.36 5.2 0.3 4.02e-7 Crohn's disease; CESC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg24154853 chr7:158122151 PTPRN2 0.43 6.65 0.38 1.68e-10 Calcium levels; CESC cis rs3768617 0.782 rs12146099 chr1:182968079 G/A ch.1.3577855R chr1:183094577 LAMC1 0.68 9.46 0.5 1.8e-18 Fuchs's corneal dystrophy; CESC cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg21573476 chr21:45109991 RRP1B -0.45 -6.39 -0.37 7.53e-10 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18876494 chr12:69004196 RAP1B 0.62 7.49 0.42 1.04e-12 Gut microbiome composition (summer); CESC cis rs3857536 0.776 rs7765531 chr6:66932886 G/A cg07460842 chr6:66804631 NA -0.42 -5.36 -0.31 1.8e-7 Blood trace element (Cu levels); CESC cis rs9616064 0.506 rs2542038 chr22:47059282 C/T cg05621596 chr22:47072043 GRAMD4 -0.51 -8.19 -0.45 1.14e-14 Urate levels in obese individuals; CESC trans rs35110281 0.720 rs230647 chr21:44919654 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.53 -6.63 -0.38 1.89e-10 Mean corpuscular volume; CESC trans rs7902708 0.920 rs12266233 chr10:54424184 A/G cg26219051 chr22:43739629 SCUBE1 -0.48 -6.19 -0.36 2.25e-9 Bone properties (heel); CESC cis rs4975709 0.838 rs4975752 chr5:1880588 A/C cg07747251 chr5:1868357 NA 0.31 5.12 0.3 5.75e-7 Cardiovascular disease risk factors; CESC cis rs2243480 0.831 rs7806717 chr7:65393174 A/G cg18252515 chr7:66147081 NA 1.06 9.79 0.52 1.67e-19 Diabetic kidney disease; CESC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs854765 0.583 rs8078105 chr17:17853782 T/C cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC cis rs7833790 0.929 rs10958048 chr8:82792914 C/T cg27398817 chr8:82754497 SNX16 0.56 6.68 0.38 1.39e-10 Diastolic blood pressure; CESC cis rs9486719 1.000 rs926276 chr6:96868735 C/T cg18709589 chr6:96969512 KIAA0776 0.49 5.58 0.32 5.81e-8 Migraine;Coronary artery disease; CESC cis rs6964587 0.810 rs408 chr7:91556284 A/G cg01689657 chr7:91764605 CYP51A1 -0.29 -5.18 -0.3 4.38e-7 Breast cancer; CESC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.49 -0.37 4.09e-10 Developmental language disorder (linguistic errors); CESC cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg10523679 chr1:76189770 ACADM 0.72 8.72 0.47 3.21e-16 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg19099843 chr7:12443191 VWDE -0.51 -5.39 -0.31 1.59e-7 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03193417 chr12:56583536 SMARCC2 0.49 6.1 0.35 3.84e-9 Gut microbiota (bacterial taxa); CESC cis rs7178572 0.568 rs1493700 chr15:77629060 T/C cg22256960 chr15:77711686 NA -0.54 -6.86 -0.39 4.9e-11 Type 2 diabetes; CESC cis rs7520050 0.966 rs6669522 chr1:46397941 A/G cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.66e-9 Red blood cell count;Reticulocyte count; CESC cis rs1348850 0.632 rs13009207 chr2:178501632 A/G cg22681709 chr2:178499509 PDE11A -0.5 -8.05 -0.44 2.89e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4253772 0.575 rs9615364 chr22:46797503 G/A cg09491104 chr22:46646882 C22orf40 -0.49 -5.42 -0.32 1.32e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9303401 0.659 rs17822807 chr17:56687190 A/C cg10487724 chr17:56770010 TEX14;RAD51C 1.02 11.73 0.58 7.25e-26 Cognitive test performance; CESC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg25036284 chr2:26402008 FAM59B -0.61 -7.08 -0.4 1.31e-11 Gut microbiome composition (summer); CESC cis rs116095464 1.000 rs28416084 chr5:217640 G/A cg22857025 chr5:266934 NA -1.28 -14.18 -0.66 2.32e-34 Breast cancer; CESC cis rs916888 0.779 rs199528 chr17:44843136 C/T cg17911788 chr17:44343683 NA -0.6 -7.81 -0.43 1.32e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs2439831 0.702 rs2788 chr15:44064886 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.97 0.44 4.59e-14 Lung cancer in ever smokers; CESC cis rs9818758 0.607 rs56004653 chr3:49072228 T/C cg00383909 chr3:49044727 WDR6 0.89 5.24 0.31 3.23e-7 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg17724175 chr1:150552817 MCL1 -0.33 -5.09 -0.3 6.86e-7 Melanoma; CESC cis rs6963495 0.818 rs1721498 chr7:105178819 A/C cg19920283 chr7:105172520 RINT1 -0.74 -8.52 -0.46 1.19e-15 Bipolar disorder (body mass index interaction); CESC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg24642844 chr7:1081250 C7orf50 -0.73 -8.78 -0.47 2e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg17366294 chr4:99064904 C4orf37 0.61 8.55 0.46 1.01e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2860975 0.967 rs11188134 chr10:96774255 G/C cg09036531 chr10:96991505 NA -0.34 -5.04 -0.3 8.46e-7 Immune response to smallpox vaccine (IL-6); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05382772 chr11:65686513 DRAP1;C11orf68 -0.5 -6.83 -0.39 5.8200000000000003e-11 Asthma; CESC cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg22307029 chr19:49891270 CCDC155 0.55 5.99 0.35 6.76e-9 Multiple sclerosis; CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg07092213 chr7:1199455 ZFAND2A -0.48 -5.28 -0.31 2.67e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7208859 0.673 rs450585 chr17:28951039 G/A cg14008862 chr17:28927542 LRRC37B2 0.71 6.42 0.37 6.33e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg09359103 chr1:154839909 KCNN3 0.67 12.57 0.61 9.74e-29 Prostate cancer; CESC trans rs61931739 0.534 rs10844791 chr12:34211659 C/T cg26384229 chr12:38710491 ALG10B 0.65 9.28 0.5 6.46e-18 Morning vs. evening chronotype; CESC cis rs6754311 0.517 rs60453613 chr2:136527120 G/C cg07169764 chr2:136633963 MCM6 0.97 12.24 0.6 1.31e-27 Mosquito bite size; CESC cis rs6964587 1.000 rs10234071 chr7:91645152 C/G cg17063962 chr7:91808500 NA -0.57 -7.89 -0.44 8.09e-14 Breast cancer; CESC cis rs6088590 0.502 rs6059861 chr20:33068563 A/T cg24642439 chr20:33292090 TP53INP2 0.52 6.83 0.39 5.95e-11 Coronary artery disease; CESC cis rs11203032 0.831 rs2211599 chr10:90929547 G/A cg16672925 chr10:90967113 CH25H 0.7 6.65 0.38 1.62e-10 Heart failure; CESC cis rs7809950 0.678 rs982447 chr7:106973534 T/C cg23024343 chr7:107201750 COG5 -0.57 -7.3 -0.41 3.37e-12 Coronary artery disease; CESC cis rs7692995 1.000 rs7662221 chr4:17966468 G/A cg08925142 chr4:18023851 LCORL -0.45 -5.13 -0.3 5.66e-7 Height; CESC cis rs6088590 1.000 rs6088590 chr20:33313566 T/C cg06115741 chr20:33292138 TP53INP2 0.58 7.14 0.4 9.16e-12 Coronary artery disease; CESC cis rs3087591 1.000 rs12600974 chr17:29589360 A/G cg24425628 chr17:29625626 OMG;NF1 0.43 5.21 0.31 3.73e-7 Hip circumference; CESC cis rs858239 0.539 rs4377861 chr7:23185969 C/T cg23682824 chr7:23144976 KLHL7 0.43 5.44 0.32 1.21e-7 Cerebrospinal fluid biomarker levels; CESC cis rs4561483 0.798 rs33629 chr16:11997490 G/A cg08843971 chr16:11963173 GSPT1 -0.41 -5.75 -0.33 2.47e-8 Testicular germ cell tumor; CESC cis rs12220238 1.000 rs11000897 chr10:75911276 C/A cg19889307 chr10:75911429 ADK;AP3M1 0.65 6.33 0.36 1.03e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs9291683 0.530 rs73227883 chr4:9979279 T/C cg00071950 chr4:10020882 SLC2A9 0.79 14.43 0.66 3.23e-35 Bone mineral density; CESC trans rs997295 0.592 rs8026627 chr15:67770306 G/T cg05081167 chr6:156967138 NA -0.28 -6.32 -0.36 1.11e-9 Motion sickness; CESC cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20285559 chr1:6688542 THAP3 -0.64 -7.53 -0.42 8.03e-13 Gut microbiome composition (summer); CESC cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg14983838 chr19:29218262 NA 0.5 6.16 0.35 2.67e-9 Methadone dose in opioid dependence; CESC cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs826838 0.904 rs11612004 chr12:39204282 G/A cg26384229 chr12:38710491 ALG10B 0.78 13.13 0.63 1.09e-30 Heart rate; CESC cis rs6060717 0.536 rs11696912 chr20:34497660 C/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.69 -6.2 -0.36 2.16e-9 Hip circumference adjusted for BMI; CESC cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg06636001 chr8:8085503 FLJ10661 0.41 5.35 0.31 1.92e-7 Mood instability; CESC trans rs6089829 0.926 rs1060491 chr20:61665817 C/A cg23505145 chr19:12996616 KLF1 -0.52 -6.64 -0.38 1.82e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs9611565 0.546 rs739134 chr22:42089623 T/C cg06634786 chr22:41940651 POLR3H 0.61 6.26 0.36 1.54e-9 Vitiligo; CESC cis rs7824557 0.545 rs2572380 chr8:11237477 A/G cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.48e-14 Retinal vascular caliber; CESC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg11644478 chr21:40555479 PSMG1 1.03 16.6 0.71 6.66e-43 Cognitive function; CESC cis rs9309473 1.000 rs7558944 chr2:73810909 T/G cg20560298 chr2:73613845 ALMS1 -0.53 -6.85 -0.39 5.01e-11 Metabolite levels; CESC cis rs2412459 0.611 rs4924402 chr15:40245754 C/T cg22077389 chr15:40226273 EIF2AK4 -0.47 -5.29 -0.31 2.61e-7 Response to haloperidol in psychosis; CESC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.16e-7 Aortic root size; CESC cis rs798766 1.000 rs3099555 chr4:1725651 T/C cg10756475 chr4:1757242 NA 0.46 6.22 0.36 1.92e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg13393036 chr8:95962371 TP53INP1 -0.55 -12.59 -0.61 8.5e-29 Type 2 diabetes; CESC cis rs2070677 0.935 rs4350328 chr10:135414948 G/A cg20169779 chr10:135381914 SYCE1 -0.74 -9.65 -0.51 4.61e-19 Gout; CESC cis rs4234798 1.000 rs4234797 chr4:7219907 C/T cg18431297 chr4:7219810 SORCS2 0.44 6.85 0.39 5.13e-11 Insulin-like growth factors; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04908382 chr14:105415856 AHNAK2 -0.41 -6.22 -0.36 1.93e-9 Gut microbiota (bacterial taxa); CESC cis rs9486719 0.894 rs34826652 chr6:96899085 A/G cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.21e-15 Migraine;Coronary artery disease; CESC cis rs858239 0.899 rs7794684 chr7:23310805 A/G cg23682824 chr7:23144976 KLHL7 0.44 5.63 0.33 4.54e-8 Cerebrospinal fluid biomarker levels; CESC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs1879734 0.731 rs11206197 chr1:54165831 A/G cg23596471 chr1:54105337 GLIS1 0.33 5.43 0.32 1.3e-7 Mitral valve prolapse; CESC cis rs2859741 0.565 rs12031540 chr1:37513757 C/T cg09363841 chr1:37513479 NA -0.55 -8.52 -0.46 1.24e-15 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs317689 0.918 rs689415 chr12:69738139 A/G cg20891283 chr12:69753455 YEATS4 -0.63 -7.14 -0.4 8.89e-12 Response to diuretic therapy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15641060 chr11:1977951 NA -0.6 -6.91 -0.39 3.55e-11 Gut microbiome composition (summer); CESC cis rs8020095 0.571 rs10136344 chr14:67410477 A/C cg19548862 chr14:67692701 FAM71D -0.49 -6.05 -0.35 5e-9 Depression (quantitative trait); CESC cis rs6912958 0.728 rs6923230 chr6:88213949 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.62 -0.38 1.95e-10 Monocyte percentage of white cells; CESC cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg16144293 chr14:75469539 EIF2B2 -0.38 -5.03 -0.3 9e-7 Height; CESC cis rs10905065 0.827 rs7089100 chr10:5849877 C/G cg11519256 chr10:5708881 ASB13 0.39 5.17 0.3 4.69e-7 Menopause (age at onset); CESC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg24503407 chr1:205819492 PM20D1 0.79 12.68 0.61 4.22e-29 Menarche (age at onset); CESC trans rs116095464 0.558 rs7736600 chr5:231337 A/C cg00938859 chr5:1591904 SDHAP3 0.63 6.87 0.39 4.48e-11 Breast cancer; CESC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.68 9.51 0.5 1.18e-18 Prudent dietary pattern; CESC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg02725872 chr8:58115012 NA -0.42 -5.72 -0.33 2.88e-8 Developmental language disorder (linguistic errors); CESC cis rs17209837 0.607 rs45496691 chr7:87110795 C/A cg00919237 chr7:87102261 ABCB4 -0.49 -6.5 -0.37 4.02e-10 Gallbladder cancer; CESC cis rs7084402 1.000 rs1346301 chr10:60267310 G/A cg07615347 chr10:60278583 BICC1 -0.61 -9.58 -0.51 7.18e-19 Refractive error; CESC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg11644478 chr21:40555479 PSMG1 1.02 16.35 0.71 4.95e-42 Cognitive function; CESC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.24 -0.31 3.23e-7 Lung cancer; CESC cis rs10489525 0.560 rs10858062 chr1:115602563 A/G cg12756093 chr1:115239321 AMPD1 -0.45 -5.44 -0.32 1.19e-7 Autism; CESC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.89 0.34 1.14e-8 Menopause (age at onset); CESC cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.66e-28 Colonoscopy-negative controls vs population controls; CESC trans rs10242455 0.557 rs2404487 chr7:99038057 G/A cg09045935 chr12:6379348 NA 0.91 7.41 0.41 1.73e-12 Blood metabolite levels; CESC cis rs1801251 1.000 rs6747645 chr2:233571033 C/T cg08000102 chr2:233561755 GIGYF2 -0.68 -9.7 -0.51 3.11e-19 Coronary artery disease; CESC cis rs3857536 0.813 rs6904511 chr6:66939102 A/C cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs2235642 0.928 rs1057610 chr16:1605537 T/C cg07639376 chr16:1584516 IFT140;TMEM204 -0.32 -5.25 -0.31 3.11e-7 Coronary artery disease; CESC trans rs6600671 0.934 rs67718113 chr1:121238910 C/T cg17023122 chr1:144479586 NA -0.51 -6.87 -0.39 4.58e-11 Hip geometry; CESC cis rs7084402 0.967 rs1427200 chr10:60274928 C/T cg07615347 chr10:60278583 BICC1 -0.57 -8.96 -0.48 6.01e-17 Refractive error; CESC cis rs6815814 0.950 rs55830619 chr4:38807364 G/A cg02016764 chr4:38805732 TLR1 -0.63 -7.11 -0.4 1.06e-11 Breast cancer; CESC cis rs6430585 0.583 rs3769013 chr2:136556182 C/T cg07169764 chr2:136633963 MCM6 1.24 18.81 0.76 1.03e-50 Corneal structure; CESC cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg06028605 chr16:24865363 SLC5A11 -0.34 -5.3 -0.31 2.39e-7 Intelligence (multi-trait analysis); CESC cis rs7178572 0.568 rs12910480 chr15:77664212 G/C cg22256960 chr15:77711686 NA -0.53 -6.77 -0.38 8.05e-11 Type 2 diabetes; CESC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC cis rs472402 0.560 rs6874005 chr5:6624371 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.46 -6.08 -0.35 4.1e-9 Response to amphetamines; CESC cis rs12410462 1.000 rs16847833 chr1:227626662 G/A cg04117972 chr1:227635322 NA 0.62 6.34 0.36 9.91e-10 Major depressive disorder; CESC cis rs11055034 0.560 rs2024385 chr12:12888438 A/T cg04607235 chr12:12878440 APOLD1 0.65 9.22 0.49 9.28e-18 Birth weight; CESC cis rs9811920 0.638 rs796978 chr3:99564321 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -6.11 -0.35 3.48e-9 Axial length; CESC cis rs116095464 1.000 rs6879758 chr5:350277 G/C cg22857025 chr5:266934 NA -0.84 -5.33 -0.31 2.14e-7 Breast cancer; CESC cis rs13034020 0.522 rs12988616 chr2:61244663 A/C cg18625361 chr2:61244694 PEX13;PUS10 0.62 6.42 0.37 6.39e-10 Hodgkin's lymphoma; CESC cis rs9894429 0.966 rs6565604 chr17:79589242 G/A cg21984481 chr17:79567631 NPLOC4 -0.47 -7.63 -0.42 4.29e-13 Eye color traits; CESC cis rs863345 0.548 rs1032352 chr1:158493154 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.84e-11 Pneumococcal bacteremia; CESC cis rs7605827 0.930 rs13017972 chr2:15699739 A/G cg19274914 chr2:15703543 NA 0.37 6.58 0.37 2.43e-10 Educational attainment (years of education); CESC cis rs950169 1.000 rs11638394 chr15:84778928 G/A cg17507749 chr15:85114479 UBE2QP1 0.6 6.54 0.37 3.16e-10 Schizophrenia; CESC cis rs1707322 0.721 rs6429575 chr1:46134216 G/C cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06857516 chr19:48205035 GLTSCR1 -0.6 -6.38 -0.36 7.94e-10 Gut microbiome composition (summer); CESC cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg10845886 chr2:3471009 TTC15 -0.67 -9.29 -0.5 5.87e-18 Neurofibrillary tangles; CESC cis rs1461503 0.900 rs10892935 chr11:122838590 C/T cg27398637 chr11:122830231 C11orf63 -0.56 -8.42 -0.46 2.35e-15 Menarche (age at onset); CESC trans rs4927850 1.000 rs10881564 chr3:195750326 C/T cg16724585 chr3:197361211 NA -0.55 -7.03 -0.4 1.77e-11 Pancreatic cancer; CESC cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg18769074 chr3:133464867 TF -0.3 -5.78 -0.33 2.08e-8 Iron status biomarkers (transferrin levels); CESC cis rs10751667 0.600 rs4076915 chr11:1012464 C/G cg01483505 chr11:975446 AP2A2 0.42 5.4 0.31 1.51e-7 Alzheimer's disease (late onset); CESC cis rs7605827 0.930 rs1997305 chr2:15512383 T/C cg19274914 chr2:15703543 NA 0.31 5.51 0.32 8.7e-8 Educational attainment (years of education); CESC cis rs72945132 0.882 rs12278125 chr11:70134016 T/C cg00319359 chr11:70116639 PPFIA1 0.78 7.74 0.43 2.13e-13 Coronary artery disease; CESC cis rs360798 0.532 rs11125942 chr2:62966758 T/C cg17519650 chr2:63277830 OTX1 -0.57 -7.48 -0.42 1.07e-12 Coronary artery disease; CESC cis rs7208859 0.673 rs216409 chr17:28906269 C/T cg19761014 chr17:28927070 LRRC37B2 -0.77 -7.28 -0.41 3.81e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs116095464 0.558 rs7715108 chr5:264661 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.49 0.32 9.44e-8 Breast cancer; CESC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg04518342 chr5:131593106 PDLIM4 0.4 5.97 0.34 7.4e-9 Breast cancer; CESC cis rs2777491 1.000 rs1757455 chr15:41761332 G/T cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.9 -0.52 7.01e-20 Ulcerative colitis; CESC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg02221750 chr19:17393354 ANKLE1 -0.52 -6.28 -0.36 1.36e-9 Systemic lupus erythematosus; CESC cis rs763121 0.853 rs3747170 chr22:39067331 G/A cg06544989 chr22:39130855 UNC84B 0.49 8.54 0.46 1.06e-15 Menopause (age at onset); CESC cis rs9473147 0.543 rs9349407 chr6:47453378 C/G cg20196966 chr6:47445060 CD2AP 0.42 5.45 0.32 1.16e-7 Platelet distribution width;Mean platelet volume; CESC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg11168104 chr5:1857477 NA -0.38 -5.64 -0.33 4.27e-8 Cardiovascular disease risk factors; CESC cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg27347728 chr4:17578864 LAP3 -0.44 -5.19 -0.3 4.22e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs10242455 0.557 rs73403272 chr7:99134208 T/G cg09045935 chr12:6379348 NA 0.83 7.07 0.4 1.4e-11 Blood metabolite levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18211447 chr14:102771717 RAGE 0.51 6.66 0.38 1.55e-10 Gut microbiota (bacterial taxa); CESC cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg07493874 chr5:1342172 CLPTM1L -0.42 -7.89 -0.44 7.92e-14 Lung cancer; CESC cis rs10189230 0.967 rs1367241 chr2:222353413 G/A cg14652038 chr2:222343519 EPHA4 0.36 7.45 0.42 1.3e-12 Urate levels in lean individuals; CESC cis rs9790314 0.540 rs35462273 chr3:160991877 C/T cg03342759 chr3:160939853 NMD3 -0.53 -7.28 -0.41 3.89e-12 Morning vs. evening chronotype; CESC cis rs7086627 0.507 rs7077907 chr10:82017082 A/G cg00277334 chr10:82204260 NA -0.44 -5.84 -0.34 1.52e-8 Post bronchodilator FEV1; CESC cis rs62344088 0.590 rs7700533 chr5:180646 C/T cg22857025 chr5:266934 NA -1.03 -6.77 -0.38 8.21e-11 Asthma (childhood onset); CESC cis rs2204008 0.805 rs3863360 chr12:37966432 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.75 0.33 2.48e-8 Bladder cancer; CESC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg03351412 chr1:154909251 PMVK 0.7 9.51 0.5 1.21e-18 Prostate cancer; CESC cis rs2710642 0.886 rs10153716 chr2:63007059 A/G cg17519650 chr2:63277830 OTX1 -0.54 -7.2 -0.4 6.35e-12 LDL cholesterol levels;LDL cholesterol; CESC cis rs2625529 0.556 rs55679065 chr15:72433395 C/T cg16672083 chr15:72433130 SENP8 0.46 7.02 0.4 1.91e-11 Red blood cell count; CESC cis rs4132509 1.000 rs10927067 chr1:243923244 C/T cg21452805 chr1:244014465 NA 0.42 5.34 0.31 2.02e-7 RR interval (heart rate); CESC cis rs712039 0.652 rs60112577 chr17:35833209 G/A cg16670864 chr17:35848621 DUSP14 0.43 5.34 0.31 2.05e-7 Tuberculosis; CESC cis rs597539 0.690 rs11228383 chr11:68623228 T/G cg21963583 chr11:68658836 MRPL21 0.4 5.42 0.32 1.37e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4722585 0.533 rs2049843 chr7:26196963 G/A cg07876897 chr7:26191696 NFE2L3 0.42 5.25 0.31 3.15e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); CESC cis rs12497850 1.000 rs6788650 chr3:48749543 T/C cg03060546 chr3:49711283 APEH 0.43 5.28 0.31 2.74e-7 Parkinson's disease; CESC cis rs708547 1.000 rs708547 chr4:57821309 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.54 -5.39 -0.31 1.58e-7 Response to bleomycin (chromatid breaks); CESC cis rs798554 1.000 rs798560 chr7:2758309 A/G cg19346786 chr7:2764209 NA -0.45 -6.56 -0.37 2.77e-10 Height; CESC cis rs7615952 0.800 rs2062773 chr3:125639648 T/C cg05084668 chr3:125655381 ALG1L -0.45 -5.44 -0.32 1.21e-7 Blood pressure (smoking interaction); CESC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.94 0.34 8.86e-9 Tonsillectomy; CESC cis rs4474465 1.000 rs11237511 chr11:78173606 C/T cg27205649 chr11:78285834 NARS2 -0.41 -5.11 -0.3 6.27e-7 Alzheimer's disease (survival time); CESC cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs11030122 0.661 rs963998 chr11:4062803 A/G cg18678763 chr11:4115507 RRM1 -0.46 -6.33 -0.36 1.03e-9 Mean platelet volume;Platelet distribution width; CESC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg06481639 chr22:41940642 POLR3H -0.62 -6.57 -0.37 2.59e-10 Vitiligo; CESC cis rs10832963 0.961 rs10832954 chr11:18643559 G/A cg20219074 chr11:18656078 SPTY2D1 0.8 11.77 0.59 5.17e-26 Breast cancer; CESC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 5.02e-9 Prudent dietary pattern; CESC cis rs9522267 0.535 rs914037 chr13:112235308 A/G cg10483660 chr13:112241077 NA -0.33 -5.78 -0.33 2.14e-8 Hepatitis; CESC cis rs1707322 1.000 rs11211243 chr1:46455433 G/C cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1559088 0.576 rs7251626 chr19:33578470 C/A cg03563238 chr19:33554763 RHPN2 -0.32 -6.02 -0.35 5.81e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1707322 0.686 rs2230659 chr1:46078884 C/T cg06784218 chr1:46089804 CCDC17 -0.43 -7.41 -0.41 1.7e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs950776 0.593 rs555018 chr15:78879242 G/A cg06917634 chr15:78832804 PSMA4 -0.6 -7.93 -0.44 6.15e-14 Sudden cardiac arrest; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21656672 chr7:2272667 MAD1L1 0.54 6.23 0.36 1.83e-9 Gut microbiome composition (summer); CESC cis rs12142240 0.698 rs1984490 chr1:46858734 C/T cg10495392 chr1:46806563 NSUN4 -0.53 -5.99 -0.35 6.67e-9 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25469212 chr1:31769620 ZCCHC17;SNRNP40 0.56 6.6 0.38 2.19e-10 Gut microbiome composition (summer); CESC cis rs72829446 0.530 rs9906913 chr17:7411360 G/A cg02795151 chr17:7402630 POLR2A 0.63 6.81 0.39 6.57e-11 Androgen levels; CESC cis rs950169 0.922 rs4586394 chr15:84822385 G/A cg17507749 chr15:85114479 UBE2QP1 -0.55 -6.31 -0.36 1.2e-9 Schizophrenia; CESC trans rs8057939 0.593 rs80233965 chr16:49406853 T/G cg15532236 chr6:170188124 NA 0.55 6.43 0.37 5.91e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs2243480 1.000 rs6460261 chr7:65215580 T/C cg12463550 chr7:65579703 CRCP -0.7 -5.35 -0.31 1.89e-7 Diabetic kidney disease; CESC cis rs7223966 1.000 rs8066719 chr17:61825764 C/T cg11494091 chr17:61959527 GH2 0.39 5.26 0.31 2.97e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4803468 1.000 rs10409485 chr19:41920765 C/T cg09537434 chr19:41945824 ATP5SL 1.05 18.8 0.76 1.09e-50 Height; CESC cis rs748404 0.560 rs689797 chr15:43826557 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.48 7.33 0.41 2.74e-12 Lung cancer; CESC cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg22834771 chr12:69754056 YEATS4 -0.48 -6.38 -0.36 7.9e-10 Blood protein levels; CESC cis rs5753037 0.702 rs140101 chr22:30128380 C/T cg01021169 chr22:30184971 ASCC2 -0.41 -5.6 -0.33 5.49e-8 Type 1 diabetes; CESC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg05368731 chr17:41323189 NBR1 0.79 10.58 0.55 4.63e-22 Menopause (age at onset); CESC trans rs62103177 0.535 rs4799109 chr18:77675188 A/T cg05926928 chr17:57297772 GDPD1 1.0 9.24 0.49 8.45e-18 Opioid sensitivity; CESC cis rs9811920 0.965 rs9837131 chr3:99854514 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.45 7.3 0.41 3.35e-12 Axial length; CESC cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg19723775 chr5:179050963 HNRNPH1 0.5 6.5 0.37 4.05e-10 Lung cancer; CESC cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg11366901 chr6:160182831 ACAT2 0.84 10.96 0.56 2.59e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs7605827 0.897 rs1996518 chr2:15517419 A/G cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg03433033 chr1:76189801 ACADM 0.62 6.78 0.38 7.6e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1865721 0.804 rs3745084 chr18:73142510 T/G cg26385618 chr18:73139727 C18orf62 -0.51 -8.18 -0.45 1.2e-14 Intelligence; CESC cis rs9814567 1.000 rs13089966 chr3:134279197 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs656900 0.715 rs673018 chr15:80115347 C/T cg02196730 chr15:80188777 MTHFS -0.41 -5.25 -0.31 3.06e-7 Cerebrospinal P-tau181p levels; CESC cis rs7208859 0.573 rs60724269 chr17:29113273 G/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.32 0.31 2.2e-7 Bipolar disorder; CESC cis rs12986413 0.624 rs2238599 chr19:2140009 C/T cg09261902 chr19:2140048 AP3D1 0.34 5.44 0.32 1.24e-7 Height; CESC cis rs2073300 1.000 rs6137971 chr20:23456429 G/T cg12062639 chr20:23401060 NAPB 0.83 5.56 0.32 6.67e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs67311347 1.000 rs9860162 chr3:40403875 C/T cg24209194 chr3:40518798 ZNF619 0.42 5.31 0.31 2.36e-7 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15012766 chr1:41832369 NA 0.55 6.78 0.38 7.69e-11 Gut microbiome composition (summer); CESC cis rs2204008 0.685 rs4556621 chr12:38187236 C/A cg26384229 chr12:38710491 ALG10B 0.73 10.54 0.54 6.41e-22 Bladder cancer; CESC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg06634786 chr22:41940651 POLR3H -0.64 -6.69 -0.38 1.3e-10 Vitiligo; CESC cis rs7762018 0.607 rs78941587 chr6:170061157 G/C cg19338460 chr6:170058176 WDR27 -0.98 -8.2 -0.45 1.08e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs60012524 1 rs60012524 chr2:99559117 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -8.4 -0.46 2.78e-15 Chronic sinus infection; CESC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg11890956 chr21:40555474 PSMG1 -0.6 -8.2 -0.45 1.04e-14 Menarche (age at onset); CESC cis rs6714710 0.603 rs11690687 chr2:98461821 C/T cg26665480 chr2:98280029 ACTR1B 0.57 8.07 0.44 2.38e-14 Posterior cortical atrophy and Alzheimer's disease; CESC trans rs10028773 0.700 rs7690338 chr4:120256468 C/G cg25214090 chr10:38739885 LOC399744 0.64 9.08 0.49 2.59e-17 Educational attainment; CESC cis rs12541635 0.966 rs12681183 chr8:107007156 T/A cg10147462 chr8:107024639 NA 0.42 5.96 0.34 7.89e-9 Age of smoking initiation; CESC cis rs7666738 0.830 rs13110410 chr4:98920018 T/C cg05340658 chr4:99064831 C4orf37 0.78 11.61 0.58 1.82e-25 Colonoscopy-negative controls vs population controls; CESC trans rs765547 0.913 rs1992442 chr8:19853389 A/C cg12649343 chr22:47023005 GRAMD4 -0.3 -6.12 -0.35 3.27e-9 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22253313 chr4:2011099 WHSC2 0.52 6.14 0.35 2.95e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13341460 chr6:126307568 TRMT11 0.62 7.13 0.4 9.79e-12 Gut microbiome composition (summer); CESC trans rs10411161 0.702 rs8113584 chr19:52383874 A/G cg22319618 chr22:45562946 NUP50 -0.7 -6.78 -0.38 7.84e-11 Breast cancer; CESC cis rs7584330 0.780 rs937395 chr2:238378749 T/C cg14458575 chr2:238380390 NA 0.71 9.71 0.51 2.83e-19 Prostate cancer; CESC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs5753618 0.504 rs5753669 chr22:31905819 T/G cg13145458 chr22:31556086 RNF185 -0.48 -5.7 -0.33 3.12e-8 Colorectal cancer; CESC cis rs2294693 0.581 rs2057000 chr6:41016952 A/C cg14418226 chr6:40996092 UNC5CL 0.42 5.46 0.32 1.08e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs910316 1.000 rs13099 chr14:75599155 G/A cg08847533 chr14:75593920 NEK9 -0.98 -18.77 -0.76 1.38e-50 Height; CESC cis rs73206853 0.563 rs1973505 chr12:111160003 A/G cg04375036 chr12:111181819 PPP1CC 0.5 5.23 0.31 3.46e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs858239 0.570 rs10242166 chr7:23162799 A/G cg23682824 chr7:23144976 KLHL7 0.55 7.71 0.43 2.59e-13 Cerebrospinal fluid biomarker levels; CESC cis rs4906332 1.000 rs12892062 chr14:103883512 A/G cg09975044 chr14:104007538 NA 0.46 6.38 0.36 7.81e-10 Coronary artery disease; CESC cis rs7937682 0.961 rs4935790 chr11:111633014 T/C cg22437258 chr11:111473054 SIK2 -0.61 -6.68 -0.38 1.38e-10 Primary sclerosing cholangitis; CESC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.07 10.18 0.53 9.37e-21 Platelet count; CESC cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg10556349 chr10:835070 NA 0.75 6.1 0.35 3.75e-9 Eosinophil percentage of granulocytes; CESC cis rs9300255 0.602 rs1716177 chr12:123655457 C/T cg19016782 chr12:123741754 C12orf65 -0.45 -6.34 -0.36 9.76e-10 Neutrophil percentage of white cells; CESC cis rs4900538 0.855 rs9788420 chr14:102839338 A/G cg18135206 chr14:102964638 TECPR2 -0.75 -9.54 -0.51 1.02e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00369908 chr12:6772357 ING4 0.54 6.11 0.35 3.45e-9 Gut microbiome composition (summer); CESC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg19099843 chr7:12443191 VWDE -0.5 -6.19 -0.36 2.34e-9 Coronary artery disease; CESC cis rs3096299 0.933 rs2965939 chr16:89493043 G/A cg16743903 chr16:89593216 SPG7 -0.42 -5.41 -0.32 1.38e-7 Multiple myeloma (IgH translocation); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20618750 chr5:149380010 HMGXB3;TIGD6 -0.45 -6.07 -0.35 4.41e-9 Gut microbiota (bacterial taxa); CESC cis rs16937 0.711 rs10751429 chr1:205107478 C/T cg00857998 chr1:205179979 DSTYK 0.39 5.22 0.31 3.67e-7 Schizophrenia; CESC cis rs2243480 1.000 rs313798 chr7:65493031 A/G cg18252515 chr7:66147081 NA -1.26 -12.38 -0.61 4.54e-28 Diabetic kidney disease; CESC cis rs941873 0.772 rs7086293 chr10:81103247 T/C cg08514558 chr10:81106712 PPIF 0.34 5.88 0.34 1.24e-8 Height; CESC cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.33e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8133932 0.608 rs382195 chr21:47339222 G/A cg14185626 chr21:47401492 COL6A1 -0.45 -5.09 -0.3 6.84e-7 Schizophrenia; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg15721424 chr11:77850393 ALG8 -0.42 -6.17 -0.35 2.52e-9 Vertical cup-disc ratio; CESC cis rs2559856 1.000 rs2559858 chr12:102089300 A/G cg15068132 chr12:102092402 CHPT1 -0.43 -5.81 -0.34 1.77e-8 Blood protein levels; CESC cis rs2072499 0.833 rs2758605 chr1:156200445 G/C cg25208724 chr1:156163844 SLC25A44 0.83 13.18 0.63 7.63e-31 Testicular germ cell tumor; CESC cis rs11638352 0.661 rs11857696 chr15:44366258 T/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.66 -6.27 -0.36 1.5e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg25427524 chr10:38739819 LOC399744 -0.7 -10.23 -0.53 6.45e-21 Extrinsic epigenetic age acceleration; CESC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs34421088 0.678 rs35928010 chr8:11591876 C/T cg13293535 chr8:11597251 GATA4 0.31 5.76 0.33 2.39e-8 Neuroticism; CESC cis rs72945132 0.882 rs7943840 chr11:70228615 C/A cg00319359 chr11:70116639 PPFIA1 0.74 7.17 0.4 7.35e-12 Coronary artery disease; CESC cis rs870825 0.616 rs10022834 chr4:185649431 A/G cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12445378 chr8:48741753 PRKDC -0.45 -6.26 -0.36 1.52e-9 Gut microbiota (bacterial taxa); CESC cis rs7089973 0.646 rs35453961 chr10:116638166 T/C cg23260525 chr10:116636907 FAM160B1 0.37 6.62 0.38 2.03e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs68170813 0.559 rs75007274 chr7:106814543 G/A cg02696742 chr7:106810147 HBP1 -0.53 -5.06 -0.3 8e-7 Coronary artery disease; CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 7.44 0.42 1.44e-12 Electroencephalogram traits; CESC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg14983838 chr19:29218262 NA 0.5 6.36 0.36 8.98e-10 Methadone dose in opioid dependence; CESC trans rs78049276 0.688 rs1878406 chr4:148393664 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.65 -6.87 -0.39 4.63e-11 Pulse pressure; CESC cis rs34779708 0.898 rs11595898 chr10:35326263 T/C cg03585969 chr10:35415529 CREM 0.75 9.82 0.52 1.31e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs760805 1.000 rs4648884 chr1:25261386 C/T cg22509179 chr1:25234806 RUNX3 0.59 8.48 0.46 1.64e-15 Allergic disease (asthma, hay fever or eczema); CESC trans rs208520 1.000 rs72882086 chr6:66976671 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.33 0.5 4.4e-18 Exhaled nitric oxide output; CESC cis rs9325144 0.555 rs7955128 chr12:38684121 A/T cg26384229 chr12:38710491 ALG10B 0.61 9.47 0.5 1.62e-18 Morning vs. evening chronotype; CESC cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg24110177 chr3:50126178 RBM5 0.58 8.17 0.45 1.28e-14 Body mass index; CESC cis rs1707322 0.963 rs12022335 chr1:46402732 C/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3806843 0.900 rs2262576 chr5:140135536 T/C cg26395211 chr5:140044315 WDR55 0.4 5.2 0.3 4.03e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1728785 1.000 rs1170434 chr16:68606590 A/G cg02972257 chr16:68554789 NA -0.68 -7.59 -0.42 5.63e-13 Ulcerative colitis; CESC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 10.23 0.53 6.56e-21 Platelet count; CESC cis rs7107174 0.748 rs11237458 chr11:78050849 A/T cg02023728 chr11:77925099 USP35 0.38 5.49 0.32 9.3e-8 Testicular germ cell tumor; CESC cis rs2243480 1.000 rs781150 chr7:65480973 C/T cg13147721 chr7:65941812 NA -0.91 -8.69 -0.47 3.87e-16 Diabetic kidney disease; CESC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.49 0.37 4.18e-10 Prudent dietary pattern; CESC cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg00033643 chr7:134001901 SLC35B4 0.44 5.62 0.33 4.89e-8 Mean platelet volume; CESC cis rs11997175 0.583 rs7824990 chr8:33779934 A/G ch.8.33884649F chr8:33765107 NA 0.47 6.04 0.35 5.26e-9 Body mass index; CESC cis rs870825 0.616 rs2003994 chr4:185636568 G/T cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs17125944 0.615 rs7150808 chr14:53304871 C/T cg00686598 chr14:53173677 PSMC6 -0.71 -6.16 -0.35 2.63e-9 Alzheimer's disease (late onset); CESC cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.11e-16 Colonoscopy-negative controls vs population controls; CESC cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.4 5.05 0.3 8.25e-7 Tonsillectomy; CESC cis rs7927771 1.000 rs11605774 chr11:47832793 G/A cg18512352 chr11:47633146 NA -0.6 -9.36 -0.5 3.59e-18 Subjective well-being; CESC cis rs77972916 0.505 rs1322 chr2:43521167 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -6.28 -0.36 1.38e-9 Granulocyte percentage of myeloid white cells; CESC cis rs9473147 0.602 rs9296567 chr6:47553402 G/A cg20196966 chr6:47445060 CD2AP 0.41 5.22 0.31 3.55e-7 Platelet distribution width;Mean platelet volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21774377 chr6:34760070 UHRF1BP1 0.49 6.25 0.36 1.62e-9 Gut microbiota (bacterial taxa); CESC cis rs10883723 0.810 rs3740406 chr10:104272789 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.76e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs7264396 0.515 rs2425134 chr20:34339439 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -10.41 -0.54 1.67e-21 Total cholesterol levels; CESC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg18230493 chr5:56204884 C5orf35 -0.73 -8.65 -0.47 4.94e-16 Initial pursuit acceleration; CESC cis rs11112613 0.713 rs12321309 chr12:105943263 T/G cg03607813 chr12:105948248 NA 0.6 6.77 0.38 8.3e-11 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC trans rs9325144 0.555 rs2387847 chr12:38687434 C/T cg23762105 chr12:34175262 ALG10 -0.46 -6.15 -0.35 2.77e-9 Morning vs. evening chronotype; CESC cis rs7395581 0.877 rs10838690 chr11:47335075 A/G cg25783544 chr11:47291846 MADD 0.61 8.04 0.44 2.9e-14 HDL cholesterol; CESC cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.47e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23464032 chr5:145214937 PRELID2 0.57 6.29 0.36 1.29e-9 Gut microbiome composition (summer); CESC cis rs6967414 1.000 rs6967414 chr7:6749758 G/A cg00387323 chr7:6746715 ZNF12 0.62 6.65 0.38 1.68e-10 Hematocrit;Hemoglobin concentration; CESC trans rs61931739 0.517 rs11053224 chr12:34484919 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.43 0.54 1.47e-21 Morning vs. evening chronotype; CESC cis rs35110281 0.627 rs1436291 chr21:44965485 T/C cg01579765 chr21:45077557 HSF2BP -0.51 -8.35 -0.46 3.84e-15 Mean corpuscular volume; CESC cis rs2075371 0.637 rs13245165 chr7:133951492 A/T cg00033643 chr7:134001901 SLC35B4 0.4 5.14 0.3 5.22e-7 Mean platelet volume; CESC cis rs4803468 0.967 rs7259900 chr19:41889429 A/T cg08477640 chr19:41863820 B9D2 0.38 5.08 0.3 6.98e-7 Height; CESC cis rs4853012 0.793 rs6723185 chr2:74344884 T/A cg05776053 chr2:74358815 NA 0.4 5.04 0.3 8.64e-7 Gestational age at birth (maternal effect); CESC cis rs2708240 0.560 rs4574770 chr7:147559736 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.39 -6.32 -0.36 1.08e-9 QT interval (drug interaction); CESC cis rs1018836 0.923 rs13259842 chr8:91550819 A/G cg16814680 chr8:91681699 NA -0.71 -10.5 -0.54 8.8e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4664308 0.594 rs4665141 chr2:160890795 A/T cg03641300 chr2:160917029 PLA2R1 -0.59 -8.54 -0.46 1.04e-15 Idiopathic membranous nephropathy; CESC cis rs17376456 0.825 rs66564678 chr5:93165894 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 5.09 0.3 6.64e-7 Diabetic retinopathy; CESC cis rs7949030 0.588 rs2509982 chr11:62312318 C/T cg11742103 chr11:62369870 EML3;MTA2 0.57 8.62 0.47 6.29e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2953174 0.786 rs2953145 chr2:241515596 C/G cg07929629 chr2:241523174 NA -0.48 -5.73 -0.33 2.74e-8 Bipolar disorder; CESC cis rs4604732 0.631 rs60311891 chr1:247623127 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.42 5.16 0.3 4.96e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4812048 0.602 rs59637156 chr20:57619618 T/C cg14073986 chr20:57617431 SLMO2 0.83 7.46 0.42 1.22e-12 Mean platelet volume; CESC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -12.0 -0.59 8.92e-27 Alzheimer's disease; CESC cis rs4481887 0.927 rs12731721 chr1:248474210 G/A cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs926938 0.563 rs360642 chr1:115425429 C/G cg12756093 chr1:115239321 AMPD1 0.5 7.09 0.4 1.21e-11 Autism; CESC cis rs74781061 0.929 rs76160708 chr15:74929242 A/G cg17294928 chr15:75287854 SCAMP5 -0.49 -5.23 -0.31 3.42e-7 Endometriosis; CESC cis rs12142240 0.667 rs45524035 chr1:46862780 C/T cg10495392 chr1:46806563 NSUN4 0.56 6.17 0.35 2.61e-9 Menopause (age at onset); CESC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg06873352 chr17:61820015 STRADA 0.73 13.07 0.63 1.78e-30 Prudent dietary pattern; CESC cis rs9388451 0.531 rs9401850 chr6:126151000 T/G cg05901451 chr6:126070800 HEY2 -0.44 -5.89 -0.34 1.16e-8 Brugada syndrome; CESC cis rs11229555 1.000 rs8373 chr11:58378424 A/G cg15696309 chr11:58395628 NA -0.43 -5.64 -0.33 4.3e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg22968622 chr17:43663579 NA -1.15 -15.19 -0.68 6.66e-38 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs7618501 0.933 rs6809431 chr3:49804119 A/G cg21659725 chr3:3221576 CRBN 0.83 13.56 0.64 3.67e-32 Intelligence (multi-trait analysis); CESC cis rs727505 1.000 rs10246424 chr7:124494861 A/G cg23710748 chr7:124431027 NA -0.48 -7.64 -0.42 4.06e-13 Lewy body disease; CESC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.23 0.41 5.08e-12 Bipolar disorder; CESC cis rs738322 1.000 rs4379 chr22:38569171 T/C cg25457927 chr22:38595422 NA -0.3 -5.51 -0.32 8.66e-8 Cutaneous nevi; CESC cis rs7598759 0.584 rs4973409 chr2:232311871 C/T cg19187155 chr2:232395269 NMUR1 0.4 6.31 0.36 1.16e-9 Noise-induced hearing loss; CESC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg09359103 chr1:154839909 KCNN3 -0.63 -12.09 -0.6 4.29e-27 Prostate cancer; CESC cis rs3540 0.553 rs4031431 chr15:90990782 G/T cg22089800 chr15:90895588 ZNF774 0.63 8.57 0.47 8.87e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs56161922 0.730 rs74231794 chr1:207850717 G/A cg09557387 chr1:207818395 CR1L 0.68 5.03 0.3 8.85e-7 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs2235544 0.664 rs55766128 chr1:54477726 T/G cg25741118 chr1:54482237 LDLRAD1 -0.25 -6.37 -0.36 8.38e-10 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs4979906 1.000 rs11002242 chr10:79445873 G/C cg07817648 chr10:79422355 NA -0.46 -5.47 -0.32 1.02e-7 Mortality in heart failure; CESC cis rs858239 1.000 rs166663 chr7:23316742 A/C cg23682824 chr7:23144976 KLHL7 0.45 5.86 0.34 1.4e-8 Cerebrospinal fluid biomarker levels; CESC cis rs3768617 0.966 rs6669796 chr1:183082825 G/C ch.1.3577855R chr1:183094577 LAMC1 0.65 8.99 0.48 4.91e-17 Fuchs's corneal dystrophy; CESC cis rs826838 1.000 rs1963562 chr12:38662896 C/T cg26384229 chr12:38710491 ALG10B 0.82 14.26 0.66 1.22e-34 Heart rate; CESC cis rs2066819 1.000 rs76745316 chr12:56627652 A/C cg26734620 chr12:56694298 CS 1.04 6.26 0.36 1.51e-9 Psoriasis vulgaris; CESC trans rs3087243 0.755 rs231797 chr2:204706107 A/G cg01841312 chr10:38069945 NA 0.37 6.23 0.36 1.85e-9 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg26314531 chr2:26401878 FAM59B -0.71 -8.09 -0.45 2.16e-14 Gut microbiome composition (summer); CESC cis rs2637266 0.783 rs2395434 chr10:78476161 T/C cg18941641 chr10:78392320 NA 0.4 7.58 0.42 5.65e-13 Pulmonary function; CESC cis rs12983728 0.831 rs79222418 chr19:58664418 T/C cg24884572 chr19:58661833 ZNF329 0.59 5.53 0.32 7.83e-8 Cholesterol, total; CESC cis rs17533156 0.525 rs77932036 chr17:75207586 T/G cg18815765 chr17:75136729 SEC14L1 0.63 6.32 0.36 1.09e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6570726 0.935 rs400968 chr6:145819718 A/G cg23711669 chr6:146136114 FBXO30 0.76 11.32 0.57 1.68e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs2273669 0.667 rs6918331 chr6:109317394 C/G cg05315195 chr6:109294784 ARMC2 -0.66 -6.37 -0.36 8.17e-10 Prostate cancer; CESC cis rs3126085 0.935 rs12726613 chr1:152185500 C/G cg03465714 chr1:152285911 FLG 0.44 5.25 0.31 3.16e-7 Atopic dermatitis; CESC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.75 0.38 9.1e-11 Bipolar disorder; CESC cis rs16854884 0.657 rs920159 chr3:143753194 A/T cg06585982 chr3:143692056 C3orf58 0.5 6.71 0.38 1.18e-10 Economic and political preferences (feminism/equality); CESC cis rs1904096 0.506 rs10028613 chr4:95223698 T/C cg11021082 chr4:95130006 SMARCAD1 -0.62 -9.36 -0.5 3.52e-18 Type 2 diabetes; CESC cis rs8062405 0.755 rs7186573 chr16:28587389 T/C cg07382826 chr16:28625726 SULT1A1 0.4 6.63 0.38 1.93e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19909111 chr2:232329248 NCL 0.53 6.0 0.35 6.42e-9 Gut microbiome composition (summer); CESC cis rs116161686 0.500 rs55871867 chr1:210051029 A/G cg25204440 chr1:209979598 IRF6 0.64 6.07 0.35 4.36e-9 Coronary artery disease; CESC cis rs55692468 0.606 rs6759772 chr2:153322724 C/T cg04681845 chr2:153283485 FMNL2 -0.28 -5.79 -0.34 1.94e-8 Intraocular pressure; CESC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg05863683 chr7:1912471 MAD1L1 0.41 6.05 0.35 4.95e-9 Bipolar disorder and schizophrenia; CESC cis rs9303401 0.921 rs34102441 chr17:56877414 A/G cg12560992 chr17:57184187 TRIM37 0.49 5.54 0.32 7.42e-8 Cognitive test performance; CESC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.16 -0.63 8.66e-31 Developmental language disorder (linguistic errors); CESC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg19774624 chr17:42201019 HDAC5 -0.81 -12.45 -0.61 2.6e-28 Total body bone mineral density; CESC cis rs1065852 0.526 rs2097561 chr22:42389431 T/C cg22189786 chr22:42395067 WBP2NL 0.43 5.42 0.32 1.33e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs7264396 0.779 rs2425162 chr20:34429974 G/A cg17201900 chr20:34330562 RBM39 0.51 5.14 0.3 5.24e-7 Total cholesterol levels; CESC cis rs11098499 0.909 rs7681214 chr4:120385320 C/A cg09307838 chr4:120376055 NA 0.95 13.96 0.65 1.42e-33 Corneal astigmatism; CESC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg15052019 chr19:19431593 KIAA0892;SF4 0.41 5.24 0.31 3.28e-7 Tonsillectomy; CESC cis rs2243480 1.000 rs34933526 chr7:65383199 A/G cg12463550 chr7:65579703 CRCP 0.7 5.58 0.32 5.87e-8 Diabetic kidney disease; CESC cis rs4319547 1.000 rs1392236 chr12:123074890 C/G cg23029597 chr12:123009494 RSRC2 -0.49 -5.4 -0.31 1.48e-7 Body mass index; CESC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg11247378 chr22:39784982 NA 0.56 7.97 0.44 4.89e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7017914 0.967 rs7819332 chr8:71668265 G/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg07677032 chr17:61819896 STRADA -0.43 -5.7 -0.33 3.16e-8 Prudent dietary pattern; CESC cis rs748404 0.631 rs7166812 chr15:43644760 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.54 8.25 0.45 7.69e-15 Lung cancer; CESC cis rs9287719 0.774 rs4997811 chr2:10755538 T/C cg02196655 chr2:10830764 NOL10 -0.37 -5.51 -0.32 8.5e-8 Prostate cancer; CESC cis rs9486719 0.948 rs2472904 chr6:96874962 T/G cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs2766692 1.000 rs2766692 chr14:100684192 C/T cg14866419 chr14:100704911 YY1 0.62 7.93 0.44 6.23e-14 Electroencephalographic traits in alcoholism; CESC cis rs11792861 0.926 rs11788825 chr9:111829757 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.46 6.04 0.35 5.3300000000000004e-09 Menarche (age at onset); CESC cis rs7216064 1.000 rs7223930 chr17:65842186 G/A cg12091567 chr17:66097778 LOC651250 -0.81 -9.14 -0.49 1.72e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs8067354 0.574 rs1291947 chr17:57996336 G/T cg13753209 chr17:57696993 CLTC 0.52 5.7 0.33 3.21e-8 Hemoglobin concentration; CESC cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg17366294 chr4:99064904 C4orf37 0.62 8.8 0.48 1.82e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 1.000 rs316312 chr7:65596491 T/G cg13147721 chr7:65941812 NA -0.99 -9.4 -0.5 2.68e-18 Diabetic kidney disease; CESC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC cis rs17376456 0.877 rs13173952 chr5:93307557 A/T cg21475434 chr5:93447410 FAM172A 0.75 6.81 0.39 6.56e-11 Diabetic retinopathy; CESC cis rs2463822 0.669 rs72919475 chr11:62042361 T/A cg06239285 chr11:62104954 ASRGL1 -1.09 -8.77 -0.47 2.15e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs7149337 0.805 rs2999355 chr14:51607084 A/G cg23942311 chr14:51606299 NA 0.48 8.36 0.46 3.56e-15 Cancer; CESC cis rs400736 0.930 rs370812 chr1:8075894 C/T cg25007680 chr1:8021821 PARK7 0.71 10.26 0.53 5.13e-21 Response to antidepressants and depression; CESC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs11958404 0.932 rs72816588 chr5:157434390 C/T cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs748404 0.650 rs518234 chr15:43573421 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.3 0.45 5.45e-15 Lung cancer; CESC cis rs2749592 0.588 rs2504144 chr10:38383525 C/T cg00409905 chr10:38381863 ZNF37A -0.55 -7.05 -0.4 1.56e-11 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs10899021 1.000 rs11236202 chr11:74376692 A/G cg25880958 chr11:74394337 NA -0.73 -6.74 -0.38 9.58e-11 Response to metformin (IC50); CESC cis rs17666538 0.710 rs11987001 chr8:630755 T/C cg23958373 chr8:599963 NA 0.77 5.48 0.32 9.95e-8 IgG glycosylation; CESC cis rs854765 0.575 rs2955357 chr17:17946401 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.54 -7.02 -0.4 1.86e-11 Total body bone mineral density; CESC cis rs790123 1.000 rs790113 chr3:122383276 T/A cg17380795 chr3:122379686 NA 0.35 5.2 0.3 3.95e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs2963155 0.518 rs10482614 chr5:142782402 C/T cg17617527 chr5:142782415 NR3C1 0.84 7.59 0.42 5.45e-13 Breast cancer; CESC cis rs6460942 0.591 rs6942432 chr7:12338393 A/G cg06484146 chr7:12443880 VWDE -0.63 -7.0 -0.4 2.06e-11 Coronary artery disease; CESC cis rs1451375 0.617 rs2329366 chr7:50544966 G/A cg14593290 chr7:50529359 DDC -0.54 -6.5 -0.37 4.05e-10 Malaria; CESC cis rs2228479 0.867 rs76885005 chr16:89966668 A/G cg14709524 chr16:89940631 TCF25 0.7 5.52 0.32 8.08e-8 Skin colour saturation; CESC cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg10556349 chr10:835070 NA -0.7 -6.0 -0.35 6.38e-9 Eosinophil percentage of granulocytes; CESC trans rs815815 0.943 rs815811 chr2:47377472 A/G cg07997434 chr2:238864969 NA -0.48 -6.0 -0.35 6.4e-9 Dialysis-related mortality; CESC cis rs7666738 0.830 rs60391193 chr4:98933912 T/G cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg07507251 chr3:52567010 NT5DC2 -0.33 -5.59 -0.32 5.62e-8 Electroencephalogram traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16247290 chr7:36429691 ANLN;KIAA0895 0.47 6.17 0.35 2.48e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9457247 0.967 rs376097 chr6:167410878 A/G cg23791538 chr6:167370224 RNASET2 -0.61 -8.81 -0.48 1.71e-16 Crohn's disease; CESC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg27170947 chr2:26402098 FAM59B -0.87 -9.77 -0.51 1.86e-19 Gut microbiome composition (summer); CESC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.41 -0.37 6.63e-10 Life satisfaction; CESC cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg26516362 chr5:178986906 RUFY1 0.37 5.38 0.31 1.63e-7 Lung cancer; CESC cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.33 0.31 2.1e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.25e-8 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.7 0.43 2.77e-13 Prudent dietary pattern; CESC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg02428538 chr16:24856791 SLC5A11 -0.48 -5.04 -0.3 8.68e-7 Intelligence (multi-trait analysis); CESC cis rs9549367 0.713 rs3024745 chr13:113821598 A/G cg00898013 chr13:113819073 PROZ -0.54 -7.3 -0.41 3.29e-12 Platelet distribution width; CESC cis rs4950322 0.570 rs72691097 chr1:146771388 C/T cg22381352 chr1:146742008 CHD1L -0.46 -5.05 -0.3 8.32e-7 Protein quantitative trait loci; CESC cis rs477692 0.673 rs556253 chr10:131355781 G/A cg24747557 chr10:131355152 MGMT -0.39 -5.43 -0.32 1.3e-7 Response to temozolomide; CESC cis rs1577917 1.000 rs35761942 chr6:86629504 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.32 -0.36 1.09e-9 Response to antipsychotic treatment; CESC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg10053473 chr17:62856997 LRRC37A3 0.65 7.33 0.41 2.74e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg11965913 chr1:205819406 PM20D1 -0.44 -6.13 -0.35 3.11e-9 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs617219 0.889 rs1717567 chr5:78435762 C/T cg22188827 chr5:78429774 NA 0.41 5.12 0.3 5.91e-7 Betaine levels in individuals undergoing cardiac evaluation; CESC cis rs897984 0.762 rs4889599 chr16:30968589 C/T cg00531865 chr16:30841666 NA 0.51 7.02 0.4 1.83e-11 Dementia with Lewy bodies; CESC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg14393609 chr7:65229607 NA -0.47 -6.31 -0.36 1.14e-9 Aortic root size; CESC cis rs7829975 0.871 rs7829826 chr8:8578120 T/A cg06636001 chr8:8085503 FLJ10661 -0.42 -5.38 -0.31 1.64e-7 Mood instability; CESC cis rs910316 0.839 rs35977276 chr14:75637359 A/C cg08847533 chr14:75593920 NEK9 -0.98 -17.94 -0.74 1.17e-47 Height; CESC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg16606324 chr3:10149918 C3orf24 -0.42 -5.27 -0.31 2.9e-7 Alzheimer's disease; CESC cis rs921968 0.541 rs578450 chr2:219401237 C/T cg02176678 chr2:219576539 TTLL4 0.5 9.0 0.48 4.36e-17 Mean corpuscular hemoglobin concentration; CESC cis rs1499972 0.941 rs62264779 chr3:117654731 G/T cg07612923 chr3:117604196 NA 0.83 7.32 0.41 3.03e-12 Schizophrenia; CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg03188948 chr7:1209495 NA 0.58 6.69 0.38 1.3e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg14784868 chr12:69753453 YEATS4 0.92 14.62 0.67 7.03e-36 Cerebrospinal fluid biomarker levels; CESC cis rs2066819 0.892 rs117305040 chr12:56657888 A/G cg26734620 chr12:56694298 CS 1.04 6.71 0.38 1.18e-10 Psoriasis vulgaris; CESC cis rs7914558 1.000 rs11191539 chr10:104819770 A/G cg04362960 chr10:104952993 NT5C2 0.47 6.32 0.36 1.11e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12199618 chr19:2353492 SPPL2B -0.57 -6.73 -0.38 1.04e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.86 0.59 2.65e-26 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02611874 chr10:46194725 NA -0.55 -6.7 -0.38 1.27e-10 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.09 -0.4 1.21e-11 Gut microbiome composition (summer); CESC trans rs11098499 0.954 rs17005535 chr4:120411562 C/T cg25214090 chr10:38739885 LOC399744 0.71 10.17 0.53 1.02e-20 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05851844 chr12:16035312 STRAP 0.56 6.27 0.36 1.46e-9 Gut microbiome composition (summer); CESC cis rs72781680 0.898 rs72786279 chr2:24063266 C/T cg08917208 chr2:24149416 ATAD2B 0.93 8.48 0.46 1.57e-15 Lymphocyte counts; CESC cis rs12530845 0.623 rs73721677 chr7:135354238 C/A cg23117316 chr7:135346802 PL-5283 -0.59 -6.39 -0.37 7.54e-10 Red blood cell traits; CESC cis rs3106136 0.901 rs17376488 chr4:95226548 T/C cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.56 -0.37 2.8e-10 Capecitabine sensitivity; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg01632322 chr19:4852205 PLIN3 -0.48 -6.03 -0.35 5.5e-9 Tetralogy of Fallot; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04496106 chr17:41561072 DHX8 -0.45 -6.3 -0.36 1.26e-9 Gambling; CESC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.11 -22.86 -0.81 1.3e-64 Prudent dietary pattern; CESC cis rs9467711 0.606 rs12173854 chr6:26371679 A/G cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.07e-9 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07851057 chr5:70751686 BDP1 0.6 6.65 0.38 1.63e-10 Gut microbiome composition (summer); CESC cis rs1580019 0.844 rs4723159 chr7:32512804 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.91 13.04 0.63 2.42e-30 Cognitive ability; CESC cis rs2070488 0.775 rs4407366 chr3:38521425 C/T cg24069376 chr3:38537580 EXOG 0.32 5.27 0.31 2.88e-7 Electrocardiographic conduction measures; CESC cis rs3204270 0.714 rs8074828 chr17:79657136 G/C cg18367735 chr17:79674897 NA 0.66 5.62 0.33 4.87e-8 Dental caries; CESC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs78456975 0.628 rs13426896 chr2:1554768 C/T cg26248373 chr2:1572462 NA -0.59 -6.01 -0.35 6.03e-9 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7916697 0.947 rs9783176 chr10:70002393 A/T cg06988349 chr10:69991859 ATOH7 0.38 6.4 0.37 6.94e-10 Optic disc area; CESC cis rs7666738 0.606 rs4577589 chr4:99087858 A/G cg17366294 chr4:99064904 C4orf37 0.43 5.71 0.33 3.05e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9815354 0.812 rs17217746 chr3:41926021 A/G cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg00149659 chr3:10157352 C3orf10 0.69 8.19 0.45 1.12e-14 Alzheimer's disease; CESC cis rs7589728 0.858 rs79992736 chr2:88530575 A/C cg07952391 chr2:88470173 THNSL2 0.58 6.78 0.38 7.56e-11 Plasma clusterin levels; CESC cis rs2479724 0.792 rs7739064 chr6:41834037 C/A cg17623882 chr6:41773611 USP49 -0.41 -6.01 -0.35 6.12e-9 Menarche (age at onset); CESC cis rs858239 0.669 rs1618339 chr7:23229774 T/C cg27449745 chr7:23145252 KLHL7 -0.41 -5.22 -0.31 3.59e-7 Cerebrospinal fluid biomarker levels; CESC cis rs10752881 1.000 rs12028740 chr1:182985581 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.79e-31 Colorectal cancer; CESC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.43 -0.37 5.88e-10 Electroencephalogram traits; CESC cis rs963731 0.579 rs2373497 chr2:39288098 C/T cg04010122 chr2:39346883 SOS1 -0.59 -5.4 -0.31 1.52e-7 Corticobasal degeneration; CESC cis rs3888647 0.622 rs4758618 chr11:2995186 A/T cg08508325 chr11:3079039 CARS -0.5 -9.29 -0.5 5.75e-18 Type 2 diabetes; CESC cis rs4604732 0.527 rs7546805 chr1:247627259 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.37 0.36 8.49e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7917772 0.582 rs4917978 chr10:104366353 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.39 -5.28 -0.31 2.66e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs3736485 0.934 rs17609693 chr15:51868000 T/A cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3015469 0.584 rs1950730 chr14:50875828 C/T cg26011998 chr14:51135199 SAV1 -0.55 -6.18 -0.36 2.35e-9 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs9291683 0.597 rs11723016 chr4:10126189 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -8.53 -0.46 1.11e-15 Bone mineral density; CESC cis rs1707322 0.963 rs12022335 chr1:46402732 C/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg04944784 chr2:26401820 FAM59B 0.96 10.55 0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs3749237 0.555 rs7637665 chr3:49552295 T/C cg02487422 chr3:49467188 NICN1 0.56 8.08 0.44 2.33e-14 Resting heart rate; CESC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg23590916 chr17:43697445 MGC57346 0.64 6.48 0.37 4.46e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg13607699 chr17:42295918 UBTF -0.58 -7.46 -0.42 1.22e-12 Total body bone mineral density; CESC cis rs12681366 0.734 rs4735288 chr8:95366544 C/T cg13257157 chr8:95487014 RAD54B 0.39 5.42 0.32 1.33e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg00149659 chr3:10157352 C3orf10 0.77 9.66 0.51 4.22e-19 Alzheimer's disease; CESC cis rs3780486 0.846 rs7865745 chr9:33140976 A/G cg13443165 chr9:33130375 B4GALT1 -0.43 -6.24 -0.36 1.72e-9 IgG glycosylation; CESC cis rs7917772 0.503 rs7899576 chr10:104307504 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.9e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs3806843 0.966 rs10060640 chr5:140211226 G/A cg26395211 chr5:140044315 WDR55 -0.41 -5.13 -0.3 5.69e-7 Depressive symptoms (multi-trait analysis); CESC cis rs3796352 1.000 rs34244302 chr3:53102236 C/G cg15956490 chr3:53032818 SFMBT1 0.63 5.15 0.3 5.18e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs66887589 0.774 rs9307477 chr4:120421809 G/A cg09307838 chr4:120376055 NA 0.54 7.29 0.41 3.49e-12 Diastolic blood pressure; CESC cis rs9549367 0.713 rs56002882 chr13:113830694 T/C cg18105134 chr13:113819100 PROZ -0.68 -8.12 -0.45 1.75e-14 Platelet distribution width; CESC cis rs7395581 0.918 rs61896050 chr11:47309063 T/C cg25783544 chr11:47291846 MADD 0.62 8.26 0.45 7.05e-15 HDL cholesterol; CESC cis rs7809950 0.678 rs77395658 chr7:107000651 G/A cg23024343 chr7:107201750 COG5 -0.53 -6.76 -0.38 8.95e-11 Coronary artery disease; CESC cis rs8077889 0.763 rs4792913 chr17:41854497 T/C cg26893861 chr17:41843967 DUSP3 1.0 18.45 0.75 1.94e-49 Triglycerides; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18900838 chr17:28804337 GOSR1 -0.51 -7.08 -0.4 1.29e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9326248 0.530 rs7121347 chr11:116867209 G/T cg01368799 chr11:117014884 PAFAH1B2 0.59 5.43 0.32 1.25e-7 Blood protein levels; CESC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg13607699 chr17:42295918 UBTF -0.59 -7.88 -0.44 8.46e-14 Total body bone mineral density; CESC cis rs67311347 1.000 rs9875245 chr3:40442280 G/T cg24209194 chr3:40518798 ZNF619 0.51 6.42 0.37 6.35e-10 Renal cell carcinoma; CESC cis rs6032067 0.538 rs62206429 chr20:43730333 A/G cg10761708 chr20:43804764 PI3 0.46 5.15 0.3 5.05e-7 Blood protein levels; CESC cis rs8099014 0.725 rs12373325 chr18:56087648 C/T cg12827950 chr18:55968429 NEDD4L 0.43 5.32 0.31 2.16e-7 Platelet count; CESC cis rs62458065 0.513 rs10268149 chr7:32575499 T/C cg20159608 chr7:32802032 NA -0.55 -6.15 -0.35 2.89e-9 Metabolite levels (HVA/MHPG ratio); CESC cis rs765787 0.530 rs1706830 chr15:45516229 G/A cg24006582 chr15:45444508 DUOX1 -0.58 -7.12 -0.4 1.04e-11 Uric acid levels; CESC cis rs2797160 0.547 rs10872298 chr6:125956348 A/C cg05901451 chr6:126070800 HEY2 -0.39 -5.4 -0.32 1.46e-7 Endometrial cancer; CESC cis rs7662987 0.517 rs2034696 chr4:100024322 C/G cg12011299 chr4:100065546 ADH4 0.6 6.6 0.38 2.23e-10 Smoking initiation; CESC cis rs6088590 1.000 rs6119530 chr20:33403930 A/G cg08999081 chr20:33150536 PIGU 0.61 9.14 0.49 1.7e-17 Coronary artery disease; CESC cis rs9300255 0.568 rs1790108 chr12:123636841 A/G cg19016782 chr12:123741754 C12orf65 -0.4 -5.68 -0.33 3.46e-8 Neutrophil percentage of white cells; CESC cis rs2625529 0.586 rs11639282 chr15:72435260 G/A cg16672083 chr15:72433130 SENP8 0.42 6.45 0.37 5.42e-10 Red blood cell count; CESC cis rs2243480 0.908 rs2460431 chr7:65622846 A/G cg13147721 chr7:65941812 NA 0.97 9.19 0.49 1.2e-17 Diabetic kidney disease; CESC trans rs7837860 0.588 rs17729482 chr8:89304297 T/A cg04391754 chr17:18022714 MYO15A 0.54 6.21 0.36 2.02e-9 Autism spectrum disorder or schizophrenia; CESC cis rs950776 0.593 rs621849 chr15:78872861 G/A cg24631222 chr15:78858424 CHRNA5 0.43 5.53 0.32 7.76e-8 Sudden cardiac arrest; CESC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg00129232 chr17:37814104 STARD3 -0.55 -7.26 -0.41 4.23e-12 Glomerular filtration rate (creatinine); CESC cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg20503657 chr10:835505 NA -0.46 -5.65 -0.33 4.08e-8 Eosinophil percentage of granulocytes; CESC cis rs9906944 0.707 rs9899931 chr17:47108282 G/A cg09029085 chr17:47094198 IGF2BP1 0.26 5.11 0.3 6.26e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs2651899 0.902 rs1798246 chr1:3080855 A/C cg22674798 chr1:3096360 PRDM16 0.34 6.58 0.37 2.53e-10 Migraine; CESC cis rs295137 0.836 rs1217429 chr2:201094151 G/T cg23649088 chr2:200775458 C2orf69 0.44 5.75 0.33 2.43e-8 Asthma (bronchodilator response); CESC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg04267008 chr7:1944627 MAD1L1 -0.69 -9.11 -0.49 2.03e-17 Bipolar disorder and schizophrenia; CESC cis rs1005224 0.963 rs2303345 chr14:76156609 A/G cg25116370 chr14:76127843 TTLL5;C14orf1 0.41 5.56 0.32 6.51e-8 Large artery stroke; CESC cis rs8050907 0.744 rs56235717 chr16:4524374 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs4969178 0.965 rs56658017 chr17:76396164 G/A cg20026190 chr17:76395443 PGS1 0.49 7.81 0.43 1.34e-13 HDL cholesterol levels; CESC cis rs7267979 1.000 rs4815424 chr20:25390284 T/C cg08601574 chr20:25228251 PYGB -0.37 -5.3 -0.31 2.45e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs3126085 0.935 rs991231 chr1:152211898 T/G cg03465714 chr1:152285911 FLG 0.44 5.17 0.3 4.67e-7 Atopic dermatitis; CESC cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg10523679 chr1:76189770 ACADM 0.67 7.66 0.43 3.4e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg05564831 chr3:52568323 NT5DC2 0.41 6.71 0.38 1.19e-10 Electroencephalogram traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18570646 chr15:37391424 MEIS2 -0.43 -6.36 -0.36 9.01e-10 Gut microbiota (bacterial taxa); CESC cis rs9915657 0.870 rs12941066 chr17:70141226 C/T cg06234051 chr17:70120541 SOX9 -0.43 -6.29 -0.36 1.32e-9 Thyroid hormone levels; CESC cis rs2415984 0.579 rs2123129 chr14:46960920 G/T cg14871534 chr14:47121158 RPL10L -0.36 -5.41 -0.32 1.42e-7 Number of children ever born; CESC cis rs1832871 0.655 rs4292552 chr6:158722888 G/A cg07165851 chr6:158734300 TULP4 0.61 6.77 0.38 8.06e-11 Height; CESC cis rs4964805 0.770 rs11111779 chr12:104185496 G/A cg02344784 chr12:104178138 NT5DC3 0.38 5.29 0.31 2.56e-7 Attention deficit hyperactivity disorder; CESC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.35 0.81 6.51e-63 Prudent dietary pattern; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13456812 chr6:167369504 RNASET2 0.5 6.72 0.38 1.14e-10 Gut microbiota (bacterial taxa); CESC cis rs56804039 1.000 rs67611618 chr8:8380939 T/C cg15556689 chr8:8085844 FLJ10661 -0.49 -5.28 -0.31 2.66e-7 Cervical cancer; CESC cis rs11098499 0.754 rs1511025 chr4:120240238 T/C cg09307838 chr4:120376055 NA 0.79 10.77 0.55 1.17e-22 Corneal astigmatism; CESC cis rs262150 0.659 rs2730275 chr7:158793397 A/G cg10570241 chr7:158785291 NA 0.33 5.48 0.32 1.01e-7 Facial morphology (factor 20); CESC cis rs2455799 0.573 rs2470520 chr3:15762920 C/T cg16303742 chr3:15540471 COLQ -0.39 -6.24 -0.36 1.76e-9 Mean platelet volume; CESC cis rs1451375 0.583 rs3807556 chr7:50610536 G/A cg14593290 chr7:50529359 DDC 0.52 6.26 0.36 1.53e-9 Malaria; CESC cis rs28374715 0.681 rs7162231 chr15:41591859 G/A cg02330683 chr15:41787940 ITPKA 0.48 5.73 0.33 2.77e-8 Ulcerative colitis; CESC cis rs9611565 0.918 rs9611562 chr22:41760172 T/G cg17376030 chr22:41985996 PMM1 0.65 6.9 0.39 3.73e-11 Vitiligo; CESC cis rs1957429 0.901 rs1467570 chr14:65347858 A/G cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg21248554 chr2:27665150 KRTCAP3 -0.33 -6.7 -0.38 1.27e-10 Total body bone mineral density; CESC cis rs847577 0.609 rs11765552 chr7:97822115 T/A cg21770322 chr7:97807741 LMTK2 0.86 14.68 0.67 4.05e-36 Breast cancer; CESC cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg24879335 chr3:133465180 TF 0.46 8.72 0.47 3.07e-16 Iron status biomarkers (transferrin levels); CESC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.52 0.54 7.61e-22 Prudent dietary pattern; CESC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg08470875 chr2:26401718 FAM59B -0.71 -7.42 -0.41 1.6e-12 Gut microbiome composition (summer); CESC cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg02725872 chr8:58115012 NA 0.34 5.08 0.3 7.06e-7 Developmental language disorder (linguistic errors); CESC cis rs5769707 0.749 rs8137251 chr22:50036669 G/A cg05373962 chr22:49881684 NA -0.34 -5.57 -0.32 6.18e-8 Monocyte count;Monocyte percentage of white cells; CESC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg24503407 chr1:205819492 PM20D1 0.81 13.09 0.63 1.51e-30 Menarche (age at onset); CESC cis rs7659604 0.521 rs9993206 chr4:122686957 A/G cg19671926 chr4:122722719 EXOSC9 0.58 7.28 0.41 3.72e-12 Type 2 diabetes; CESC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.78 0.33 2.15e-8 Personality dimensions; CESC cis rs2637266 0.935 rs2579728 chr10:78395598 A/G cg18941641 chr10:78392320 NA 0.45 8.6 0.47 7.12e-16 Pulmonary function; CESC cis rs896854 0.517 rs896851 chr8:95950251 T/C cg23172400 chr8:95962367 TP53INP1 -0.39 -6.79 -0.38 7.52e-11 Type 2 diabetes; CESC cis rs9911578 0.967 rs7222789 chr17:56819853 C/G cg12560992 chr17:57184187 TRIM37 0.92 15.09 0.68 1.43e-37 Intelligence (multi-trait analysis); CESC cis rs7847628 0.566 rs10739575 chr9:123606101 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.52 -5.4 -0.32 1.46e-7 Birth weight; CESC cis rs6662572 0.737 rs75490316 chr1:46553785 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.11 0.3 6.21e-7 Blood protein levels; CESC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg00149659 chr3:10157352 C3orf10 0.74 8.63 0.47 5.66e-16 Alzheimer's disease; CESC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg17376030 chr22:41985996 PMM1 0.72 7.81 0.43 1.32e-13 Vitiligo; CESC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg06873352 chr17:61820015 STRADA 0.74 13.19 0.63 7.17e-31 Prudent dietary pattern; CESC trans rs35110281 0.633 rs4819289 chr21:45120237 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.46 6.02 0.35 5.93e-9 Mean corpuscular volume; CESC cis rs7580658 0.724 rs12623948 chr2:128001342 G/A cg10021288 chr2:128175891 PROC -0.39 -6.08 -0.35 4.23e-9 Protein C levels; CESC cis rs7542091 0.506 rs992976 chr1:210066658 A/T cg21951975 chr1:209979733 IRF6 -0.37 -6.09 -0.35 3.85e-9 Monobrow; CESC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.01 11.17 0.57 5.56e-24 Platelet count; CESC cis rs17401966 0.931 rs10492972 chr1:10353112 A/G cg15208524 chr1:10270712 KIF1B 0.42 5.45 0.32 1.14e-7 Hepatocellular carcinoma; CESC cis rs116095464 0.558 rs7714335 chr5:263513 T/C cg22857025 chr5:266934 NA -1.26 -15.32 -0.69 2.17e-38 Breast cancer; CESC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.36 0.5 3.44e-18 Menopause (age at onset); CESC cis rs9837602 0.938 rs10511177 chr3:99724873 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -6.59 -0.38 2.36e-10 Breast cancer; CESC cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs909674 0.690 rs5750825 chr22:39831278 A/G cg11247378 chr22:39784982 NA -0.58 -8.53 -0.46 1.12e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs74781061 0.929 rs8029099 chr15:74766770 A/C cg17294928 chr15:75287854 SCAMP5 -0.5 -5.31 -0.31 2.35e-7 Endometriosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26652484 chr3:57582327 ARF4 -0.44 -6.24 -0.36 1.71e-9 Gut microbiota (bacterial taxa); CESC cis rs17362650 1.000 rs4464248 chr2:9691320 A/G cg12832956 chr2:9616023 IAH1 0.52 5.14 0.3 5.28e-7 Alcohol dependence (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13749939 chr11:796434 SLC25A22 -0.44 -6.62 -0.38 1.99e-10 Gambling; CESC cis rs761746 0.672 rs10775716 chr22:31992645 C/T cg25791279 chr22:32026902 PISD 0.57 5.77 0.33 2.26e-8 Intelligence; CESC cis rs12477438 0.765 rs4851183 chr2:99629149 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs7264396 0.635 rs2064724 chr20:34522520 T/C cg17201900 chr20:34330562 RBM39 0.49 5.13 0.3 5.62e-7 Total cholesterol levels; CESC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 0.41 5.43 0.32 1.26e-7 Age at first birth; CESC cis rs3733585 0.725 rs10939636 chr4:9972640 T/G cg11266682 chr4:10021025 SLC2A9 -0.58 -10.84 -0.55 6.42e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs938554 0.779 rs11735831 chr4:9951591 G/A cg11266682 chr4:10021025 SLC2A9 -0.4 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16857181 chr7:32931955 KBTBD2 0.52 6.68 0.38 1.44e-10 Gut microbiota (bacterial taxa); CESC cis rs7605827 0.930 rs13024118 chr2:15494640 A/T cg19274914 chr2:15703543 NA 0.31 5.62 0.33 4.89e-8 Educational attainment (years of education); CESC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25472998 chr6:10413233 TFAP2A -0.49 -6.11 -0.35 3.5e-9 Ulcerative colitis; CESC cis rs1348850 1.000 rs1348850 chr2:178418575 A/G cg22681709 chr2:178499509 PDE11A -0.4 -5.89 -0.34 1.17e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg04025307 chr7:1156635 C7orf50 -0.4 -6.53 -0.37 3.3e-10 Longevity;Endometriosis; CESC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC cis rs11122272 0.735 rs2572254 chr1:231512593 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -7.28 -0.41 3.86e-12 Hemoglobin concentration; CESC cis rs2204008 0.775 rs12369238 chr12:38176051 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.53 0.51 1.08e-18 Bladder cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg22025132 chr6:143771787 ADAT2;PEX3 -0.5 -6.79 -0.38 7.56e-11 Asthma; CESC cis rs3820068 0.603 rs6429769 chr1:15968610 C/G cg13390004 chr1:15929781 NA 0.34 5.61 0.33 5.11e-8 Systolic blood pressure; CESC cis rs2180341 0.920 rs9401951 chr6:127671632 A/C cg24812749 chr6:127587940 RNF146 1.06 15.02 0.68 2.7e-37 Breast cancer; CESC cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg21918786 chr6:109611834 NA -0.4 -6.05 -0.35 5.03e-9 Reticulocyte fraction of red cells; CESC trans rs7618501 0.602 rs2301166 chr3:50148305 C/G cg21659725 chr3:3221576 CRBN -0.5 -6.92 -0.39 3.32e-11 Intelligence (multi-trait analysis); CESC cis rs2109514 0.774 rs6954077 chr7:116129153 G/A cg12739419 chr7:116140593 CAV2 -0.38 -6.76 -0.38 8.91e-11 Prevalent atrial fibrillation; CESC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.35 0.81 6.51e-63 Prudent dietary pattern; CESC cis rs17601876 0.814 rs12050767 chr15:51557257 T/C cg19946085 chr15:51559439 CYP19A1 -0.35 -5.61 -0.33 5.08e-8 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg11494091 chr17:61959527 GH2 0.73 12.44 0.61 2.72e-28 Prudent dietary pattern; CESC cis rs950169 0.840 rs62029595 chr15:84955301 C/T cg17507749 chr15:85114479 UBE2QP1 0.59 6.5 0.37 4.03e-10 Schizophrenia; CESC cis rs698813 0.572 rs4953076 chr2:44480950 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.3 0.31 2.41e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg14562523 chr21:43528734 C21orf128;UMODL1 -0.37 -5.65 -0.33 4.18e-8 IgG glycosylation; CESC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg07677032 chr17:61819896 STRADA -0.47 -6.25 -0.36 1.67e-9 Prudent dietary pattern; CESC cis rs11098499 0.865 rs9996417 chr4:120295862 T/C cg24375607 chr4:120327624 NA 0.47 5.62 0.33 4.89e-8 Corneal astigmatism; CESC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg03352830 chr11:487213 PTDSS2 0.72 6.64 0.38 1.73e-10 Body mass index; CESC cis rs2996428 0.667 rs17412654 chr1:3758493 T/C cg13057898 chr1:3703894 LRRC47 0.45 6.08 0.35 4.26e-9 Red cell distribution width; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14995492 chr5:122971951 NA -0.39 -6.29 -0.36 1.3e-9 Asthma; CESC cis rs9581857 0.579 rs75326986 chr13:27997758 C/T cg22138327 chr13:27999177 GTF3A 0.65 5.5 0.32 9.07e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs72945132 0.882 rs17160039 chr11:70145489 A/G cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs9796 0.870 rs7181816 chr15:41358720 T/A cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.83 -0.39 5.74e-11 Menopause (age at onset); CESC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg24562669 chr7:97807699 LMTK2 0.54 7.91 0.44 7.09e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg14558114 chr2:88469736 THNSL2 -0.7 -10.12 -0.53 1.42e-20 Response to metformin (IC50); CESC cis rs12497850 0.931 rs11705888 chr3:48817289 T/C cg03060546 chr3:49711283 APEH 0.42 5.16 0.3 4.81e-7 Parkinson's disease; CESC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg17372223 chr3:52568218 NT5DC2 0.44 6.57 0.37 2.69e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13089318 chr1:80961776 NA -0.59 -6.96 -0.39 2.62e-11 Gut microbiome composition (summer); CESC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg26304593 chr6:42947056 PEX6 -0.42 -5.32 -0.31 2.24e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg15485101 chr11:133734466 NA 0.41 6.65 0.38 1.7e-10 Childhood ear infection; CESC trans rs1493916 0.870 rs7239173 chr18:31395534 A/T cg27147174 chr7:100797783 AP1S1 -0.54 -7.28 -0.41 3.85e-12 Life satisfaction; CESC trans rs7615952 0.641 rs12487875 chr3:125787224 C/A cg07211511 chr3:129823064 LOC729375 -0.57 -6.39 -0.37 7.57e-10 Blood pressure (smoking interaction); CESC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs9322193 0.884 rs880245 chr6:150167398 A/G cg04369109 chr6:150039330 LATS1 0.41 5.4 0.31 1.49e-7 Lung cancer; CESC cis rs2073300 0.609 rs3736755 chr20:23377642 C/T cg16736954 chr20:23401023 NAPB 0.78 6.0 0.35 6.37e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs62064224 0.791 rs11653160 chr17:30717222 A/G cg09324608 chr17:30823087 MYO1D 0.49 7.32 0.41 2.94e-12 Schizophrenia; CESC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1881797 1.000 rs12081895 chr1:247686666 C/G cg11166453 chr1:247681781 NA 0.44 5.77 0.33 2.24e-8 Acute lymphoblastic leukemia (childhood); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg27261837 chr1:146714163 CHD1L 0.49 6.7 0.38 1.28e-10 Systemic lupus erythematosus; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg02678462 chr19:5154735 NA -0.52 -6.9 -0.39 3.91e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7818688 0.578 rs11776489 chr8:95828458 G/A cg16049864 chr8:95962084 TP53INP1 0.55 5.66 0.33 3.83e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs472402 0.580 rs3822430 chr5:6651970 A/G cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.55 -7.06 -0.4 1.43e-11 Response to amphetamines; CESC cis rs3771570 1.000 rs55634485 chr2:242268994 T/C cg21155796 chr2:242212141 HDLBP 0.6 5.11 0.3 6.17e-7 Prostate cancer; CESC cis rs10504229 0.680 rs11777459 chr8:58044241 A/T cg24829409 chr8:58192753 C8orf71 -0.53 -6.49 -0.37 4.3e-10 Developmental language disorder (linguistic errors); CESC cis rs9303401 0.580 rs12946396 chr17:57164195 T/A cg10487724 chr17:56770010 TEX14;RAD51C 1.0 12.4 0.61 3.86e-28 Cognitive test performance; CESC cis rs2228479 1.000 rs4257207 chr16:89947861 T/A cg14709524 chr16:89940631 TCF25 0.89 6.56 0.37 2.74e-10 Skin colour saturation; CESC cis rs258892 0.793 rs34655 chr5:72147269 A/G cg21869765 chr5:72125136 TNPO1 0.45 5.68 0.33 3.57e-8 Small cell lung carcinoma; CESC cis rs4919687 0.550 rs12761195 chr10:104465374 T/C cg04362960 chr10:104952993 NT5C2 0.46 5.37 0.31 1.73e-7 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01172114 chr10:5979283 FBXO18 -0.58 -6.16 -0.35 2.69e-9 Gut microbiome composition (summer); CESC cis rs61931739 0.500 rs11053217 chr12:34470036 A/C cg06521331 chr12:34319734 NA -0.37 -5.04 -0.3 8.52e-7 Morning vs. evening chronotype; CESC cis rs4953076 0.573 rs9973609 chr2:44450435 T/C cg04920474 chr2:44395004 PPM1B 0.56 7.08 0.4 1.26e-11 Height; CESC cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg06784218 chr1:46089804 CCDC17 -0.29 -5.09 -0.3 6.87e-7 High light scatter reticulocyte count; CESC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg26516362 chr5:178986906 RUFY1 -0.42 -6.53 -0.37 3.35e-10 Lung cancer; CESC trans rs877282 0.898 rs34490091 chr10:765800 A/C cg22713356 chr15:30763199 NA 1.16 11.28 0.57 2.37e-24 Uric acid levels; CESC cis rs854765 0.547 rs4459604 chr17:17888549 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 7.78 0.43 1.65e-13 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05150023 chr5:42944267 NA -0.48 -6.18 -0.35 2.36e-9 Gut microbiome composition (summer); CESC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.23 -0.31 3.45e-7 Total body bone mineral density; CESC cis rs7100689 0.556 rs6585971 chr10:82145057 G/C cg00277334 chr10:82204260 NA -0.58 -7.62 -0.42 4.52e-13 Post bronchodilator FEV1; CESC cis rs8114671 0.562 rs4911449 chr20:33512236 T/G cg24642439 chr20:33292090 TP53INP2 0.44 5.32 0.31 2.18e-7 Height; CESC cis rs4843747 0.749 rs72818535 chr16:88074039 G/A cg03395651 chr16:88107091 BANP 0.44 5.13 0.3 5.57e-7 Menopause (age at onset); CESC trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg06636001 chr8:8085503 FLJ10661 -0.53 -6.81 -0.39 6.38e-11 Neuroticism; CESC cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs820218 0.886 rs820202 chr17:73636623 G/A cg01592526 chr17:73663357 RECQL5;SAP30BP 0.41 5.35 0.31 1.9e-7 Rotator cuff tears; CESC cis rs11792861 0.816 rs2304779 chr9:111670513 C/T cg13535736 chr9:111863775 C9orf5 0.46 6.22 0.36 1.97e-9 Menarche (age at onset); CESC cis rs921968 0.565 rs2272189 chr2:219610322 G/A cg02176678 chr2:219576539 TTLL4 -0.46 -8.14 -0.45 1.58e-14 Mean corpuscular hemoglobin concentration; CESC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg05564831 chr3:52568323 NT5DC2 0.46 7.05 0.4 1.58e-11 Intelligence (multi-trait analysis); CESC cis rs290986 1.000 rs290986 chr9:93563536 A/G cg02608019 chr9:93564028 SYK 0.53 5.86 0.34 1.36e-8 Multiple sclerosis; CESC cis rs317689 0.718 rs315130 chr12:69761444 T/C cg20891283 chr12:69753455 YEATS4 0.64 7.44 0.42 1.42e-12 Response to diuretic therapy; CESC cis rs13253111 0.624 rs4732844 chr8:28104473 A/G cg26534493 chr8:28060551 NA -0.47 -7.16 -0.4 8.15e-12 Childhood body mass index; CESC cis rs6570726 0.967 rs450973 chr6:145863065 C/A cg05347473 chr6:146136440 FBXO30 0.44 6.01 0.35 6.2e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs2760061 0.626 rs2796057 chr1:228124414 G/C cg01973587 chr1:228161476 NA 0.38 5.84 0.34 1.49e-8 Diastolic blood pressure; CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg17221315 chr6:27791827 HIST1H4J 0.44 5.08 0.3 7.12e-7 Depression; CESC cis rs854765 0.583 rs8080823 chr17:17864048 T/C cg09796270 chr17:17721594 SREBF1 0.48 6.53 0.37 3.37e-10 Total body bone mineral density; CESC cis rs372883 0.600 rs2832295 chr21:30739843 C/T cg24692254 chr21:30365293 RNF160 0.58 7.23 0.41 5.32e-12 Pancreatic cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19541688 chr19:46289559 DMWD 0.47 6.28 0.36 1.39e-9 Fibrinogen levels; CESC cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg11764359 chr7:65958608 NA 0.66 8.34 0.46 4.16e-15 Aortic root size; CESC cis rs992157 0.717 rs3817266 chr2:219142594 C/T cg00012203 chr2:219082015 ARPC2 -0.76 -9.55 -0.51 9.45e-19 Colorectal cancer; CESC cis rs9549367 0.713 rs3024757 chr13:113823186 G/T cg18105134 chr13:113819100 PROZ -0.7 -8.34 -0.46 4.2e-15 Platelet distribution width; CESC cis rs3892630 0.588 rs12610342 chr19:33250690 C/T cg22980127 chr19:33182716 NUDT19 1.14 14.35 0.66 6.09e-35 Red blood cell traits; CESC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg19346786 chr7:2764209 NA -0.42 -6.13 -0.35 3.18e-9 Height; CESC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg02569458 chr12:86230093 RASSF9 0.51 7.7 0.43 2.65e-13 Major depressive disorder; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg10663503 chr17:8126298 C17orf44 0.59 8.1 0.45 1.97e-14 Attention deficit hyperactivity disorder; CESC cis rs1348850 0.526 rs2178017 chr2:178374788 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.68 6.07 0.35 4.42e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2427308 0.607 rs1741635 chr20:60938197 C/G cg09594475 chr20:60884601 LAMA5 -0.46 -5.16 -0.3 4.74e-7 Colorectal cancer; CESC trans rs3780486 0.846 rs10113903 chr9:33122645 C/G cg20290983 chr6:43655470 MRPS18A -1.01 -19.01 -0.76 2.04e-51 IgG glycosylation; CESC cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg05347473 chr6:146136440 FBXO30 -0.71 -9.16 -0.49 1.48e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs12530845 0.623 rs73721681 chr7:135361917 A/G cg23117316 chr7:135346802 PL-5283 -0.57 -6.18 -0.35 2.4e-9 Red blood cell traits; CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg18402987 chr7:1209562 NA 0.74 8.54 0.46 1.07e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7599312 0.534 rs7607363 chr2:213402705 A/G cg16329650 chr2:213403929 ERBB4 0.58 8.43 0.46 2.31e-15 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1580019 0.563 rs13244332 chr7:32537679 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.07 19.57 0.77 2.21e-53 Cognitive ability; CESC cis rs7772486 0.790 rs2253880 chr6:146200774 T/C cg05347473 chr6:146136440 FBXO30 0.55 7.26 0.41 4.4e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7267979 1.000 rs7343481 chr20:25300113 C/T cg08601574 chr20:25228251 PYGB -0.39 -5.61 -0.33 5.09e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs963731 0.649 rs2278914 chr2:39218552 G/A cg04010122 chr2:39346883 SOS1 -0.76 -5.57 -0.32 6.3e-8 Corticobasal degeneration; CESC cis rs4568518 0.619 rs13238312 chr7:18008444 A/G cg03009463 chr7:17980271 SNX13 0.44 5.83 0.34 1.58e-8 Measles; CESC cis rs1215050 0.740 rs700739 chr4:99022546 A/G cg05340658 chr4:99064831 C4orf37 -0.57 -7.6 -0.42 5.27e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs10484885 0.824 rs72919981 chr6:90528977 T/C cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.12 -0.4 1.03e-11 QRS interval (sulfonylurea treatment interaction); CESC cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2486288 0.656 rs7162022 chr15:45565253 C/T cg21132104 chr15:45694354 SPATA5L1 -0.55 -6.5 -0.37 4.05e-10 Glomerular filtration rate; CESC cis rs838147 0.537 rs503279 chr19:49209010 C/T cg21064579 chr19:49206444 FUT2 -0.43 -6.08 -0.35 4.15e-9 Dietary macronutrient intake; CESC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.71 0.38 1.19e-10 Bipolar disorder; CESC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.84 0.34 1.55e-8 Tonsillectomy; CESC trans rs2658782 0.826 rs1975820 chr11:93081815 G/A cg03479527 chr8:145637966 SLC39A4 -0.42 -6.08 -0.35 4.2e-9 Pulmonary function decline; CESC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg21963583 chr11:68658836 MRPL21 0.42 5.7 0.33 3.21e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs28829049 0.597 rs2066002 chr1:19504300 G/A cg13387374 chr1:19411106 UBR4 0.43 5.41 0.32 1.43e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg03188948 chr7:1209495 NA 0.7 6.68 0.38 1.4e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3857067 0.806 rs2171379 chr4:95100243 A/T cg11021082 chr4:95130006 SMARCAD1 -0.63 -9.49 -0.5 1.44e-18 QT interval; CESC trans rs61931739 0.534 rs4931770 chr12:34044479 G/T cg26384229 chr12:38710491 ALG10B 0.6 8.36 0.46 3.68e-15 Morning vs. evening chronotype; CESC cis rs11098499 0.863 rs7669520 chr4:120515278 T/C cg09307838 chr4:120376055 NA 0.91 12.63 0.61 6.02e-29 Corneal astigmatism; CESC cis rs6696846 0.715 rs12139373 chr1:205054879 A/C cg00857998 chr1:205179979 DSTYK 0.55 7.15 0.4 8.25e-12 Red blood cell count; CESC cis rs6754311 0.628 rs309811 chr2:136625602 A/G cg07169764 chr2:136633963 MCM6 -0.69 -8.54 -0.46 1.03e-15 Mosquito bite size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15965583 chr1:150601949 ENSA 0.51 6.25 0.36 1.59e-9 Gut microbiome composition (summer); CESC cis rs6460942 1.000 rs6460938 chr7:12406808 T/G cg02935154 chr7:12443704 VWDE -0.56 -5.82 -0.34 1.71e-8 Coronary artery disease; CESC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg19622623 chr12:86230825 RASSF9 -0.43 -5.28 -0.31 2.72e-7 Major depressive disorder; CESC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg25072359 chr17:41440525 NA 0.47 6.36 0.36 8.75e-10 Menopause (age at onset); CESC cis rs1005277 0.540 rs4934907 chr10:38015230 A/C cg00409905 chr10:38381863 ZNF37A -0.5 -6.82 -0.39 6.27e-11 Extrinsic epigenetic age acceleration; CESC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg13607699 chr17:42295918 UBTF 0.57 7.42 0.41 1.58e-12 Total body bone mineral density; CESC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg17971929 chr21:40555470 PSMG1 -0.61 -7.53 -0.42 7.78e-13 Menarche (age at onset); CESC cis rs1538970 0.781 rs12049503 chr1:46021556 G/T cg05343316 chr1:45956843 TESK2 0.85 10.91 0.56 3.9e-23 Platelet count; CESC cis rs6460942 0.659 rs6969309 chr7:12515847 T/C cg02935154 chr7:12443704 VWDE -0.54 -5.44 -0.32 1.23e-7 Coronary artery disease; CESC trans rs1814175 0.817 rs1794164 chr11:49899610 T/C cg03929089 chr4:120376271 NA -0.93 -15.69 -0.69 1.12e-39 Height; CESC cis rs4780401 0.632 rs7192366 chr16:11835209 C/G cg01061890 chr16:11836724 TXNDC11 -0.58 -7.81 -0.43 1.3e-13 Rheumatoid arthritis; CESC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg06074448 chr4:187884817 NA 0.41 6.1 0.35 3.76e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs7843479 0.601 rs878873 chr8:21834581 T/C cg17168535 chr8:21777572 XPO7 0.74 11.92 0.59 1.67e-26 Mean corpuscular volume; CESC cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg07636037 chr3:49044803 WDR6 1.02 18.99 0.76 2.3e-51 Parkinson's disease; CESC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg05332525 chr7:65337924 VKORC1L1 0.52 6.41 0.37 6.6e-10 Aortic root size; CESC cis rs6500395 0.735 rs2883641 chr16:48664446 T/C cg04672837 chr16:48644449 N4BP1 0.44 5.15 0.3 4.97e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg07234876 chr8:600039 NA 0.82 5.79 0.34 1.96e-8 IgG glycosylation; CESC cis rs28647808 0.786 rs28458971 chr9:136255736 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg27170947 chr2:26402098 FAM59B 0.81 8.91 0.48 8.12e-17 Gut microbiome composition (summer); CESC cis rs4568518 0.616 rs11766489 chr7:18003670 T/C cg03009463 chr7:17980271 SNX13 0.43 5.72 0.33 2.91e-8 Measles; CESC cis rs854765 0.693 rs8079418 chr17:17924060 C/T cg09796270 chr17:17721594 SREBF1 0.36 5.16 0.3 4.91e-7 Total body bone mineral density; CESC cis rs2070488 0.761 rs6807940 chr3:38460062 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 9.91 0.52 6.66e-20 Electrocardiographic conduction measures; CESC cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg24308560 chr3:49941425 MST1R -0.63 -9.02 -0.48 3.81e-17 Intelligence (multi-trait analysis); CESC cis rs5769765 0.955 rs8138687 chr22:50291869 A/G cg26441486 chr22:50317300 CRELD2 0.39 5.37 0.31 1.76e-7 Schizophrenia; CESC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg18110333 chr6:292329 DUSP22 -0.77 -10.46 -0.54 1.16e-21 Menopause (age at onset); CESC cis rs8133932 0.621 rs1124309 chr21:47328767 C/A cg14185626 chr21:47401492 COL6A1 0.46 5.11 0.3 6.13e-7 Schizophrenia; CESC cis rs4144743 1.000 rs10438781 chr17:45323819 A/G cg18085866 chr17:45331354 ITGB3 -0.66 -7.64 -0.43 3.87e-13 Body mass index; CESC trans rs1814175 0.715 rs7479622 chr11:49673340 T/G cg03929089 chr4:120376271 NA -0.88 -13.46 -0.64 8.34e-32 Height; CESC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg26850624 chr5:429559 AHRR -0.48 -6.63 -0.38 1.85e-10 Cystic fibrosis severity; CESC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.66 0.33 3.98e-8 Electroencephalogram traits; CESC trans rs208520 0.690 rs851458 chr6:66813279 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.97 -13.03 -0.62 2.5e-30 Exhaled nitric oxide output; CESC cis rs5753618 0.539 rs5753596 chr22:31787472 C/T cg02404636 chr22:31891804 SFI1 -0.43 -6.25 -0.36 1.63e-9 Colorectal cancer; CESC cis rs2109514 0.765 rs11769417 chr7:116103778 A/G cg12739419 chr7:116140593 CAV2 -0.32 -5.71 -0.33 3.06e-8 Prevalent atrial fibrillation; CESC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg23034840 chr1:205782522 SLC41A1 0.77 10.75 0.55 1.3e-22 Monocyte percentage of white cells; CESC cis rs8114671 0.562 rs6088653 chr20:33520321 T/C cg07148914 chr20:33460835 GGT7 0.45 5.9 0.34 1.09e-8 Height; CESC cis rs17039065 0.920 rs57121318 chr4:109456755 T/C cg16022748 chr4:109541635 LOC285456;RPL34 0.63 5.78 0.33 2.08e-8 Gut microbiome composition (summer); CESC cis rs2273669 0.667 rs12215381 chr6:109363217 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.33 -0.36 1.02e-9 Prostate cancer; CESC cis rs4899554 0.640 rs1569328 chr14:75741751 A/G cg18117039 chr14:75741733 NA -0.43 -5.8 -0.34 1.85e-8 Inflammatory bowel disease; CESC cis rs9300255 0.722 rs10773008 chr12:123800820 A/G cg19016782 chr12:123741754 C12orf65 -0.43 -6.0 -0.35 6.54e-9 Neutrophil percentage of white cells; CESC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg24503407 chr1:205819492 PM20D1 -0.4 -5.32 -0.31 2.19e-7 Parkinson's disease; CESC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg12419862 chr22:24373484 LOC391322 -0.74 -10.49 -0.54 9.52e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9522267 0.535 rs9522299 chr13:112236013 C/A cg10483660 chr13:112241077 NA -0.33 -5.78 -0.33 2.14e-8 Hepatitis; CESC cis rs6076065 0.748 rs6048781 chr20:23380027 T/C cg11657817 chr20:23433608 CST11 0.4 6.1 0.35 3.7e-9 Facial morphology (factor 15, philtrum width); CESC cis rs9911578 1.000 rs7342903 chr17:56914588 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 3.04e-7 Intelligence (multi-trait analysis); CESC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg04518342 chr5:131593106 PDLIM4 0.36 5.21 0.31 3.73e-7 Breast cancer; CESC cis rs7586879 0.639 rs7567997 chr2:25096952 A/G cg01884057 chr2:25150051 NA 0.38 7.48 0.42 1.12e-12 Body mass index; CESC cis rs17125944 0.505 rs10483617 chr14:53202605 A/G cg00686598 chr14:53173677 PSMC6 -1.14 -9.14 -0.49 1.66e-17 Alzheimer's disease (late onset); CESC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg24829409 chr8:58192753 C8orf71 -0.51 -6.11 -0.35 3.63e-9 Developmental language disorder (linguistic errors); CESC cis rs1267303 0.642 rs11588450 chr1:47000996 C/T cg25110126 chr1:46999211 NA -0.77 -9.58 -0.51 7.52e-19 Monobrow; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04792727 chr1:231664260 TSNAX-DISC1;TSNAX -0.56 -6.7 -0.38 1.25e-10 Gut microbiome composition (summer); CESC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg08859206 chr1:53392774 SCP2 -0.6 -8.05 -0.44 2.89e-14 Monocyte count; CESC cis rs67257959 0.739 rs10416982 chr19:17202933 C/A cg16202187 chr19:17186497 HAUS8;MYO9B 0.43 5.19 0.3 4.26e-7 Selective IgA deficiency; CESC cis rs2243480 1.000 rs57057549 chr7:65405738 A/G cg25894440 chr7:65020034 NA -0.64 -5.31 -0.31 2.33e-7 Diabetic kidney disease; CESC cis rs897984 0.542 rs6565217 chr16:31083324 C/T cg00531865 chr16:30841666 NA -0.38 -5.44 -0.32 1.19e-7 Dementia with Lewy bodies; CESC cis rs34638657 0.828 rs7194734 chr16:82199980 C/T cg09439754 chr16:82129088 HSD17B2 -0.36 -5.38 -0.31 1.63e-7 Lung adenocarcinoma; CESC cis rs7656342 0.636 rs10012880 chr4:9835480 T/C cg11266682 chr4:10021025 SLC2A9 -0.34 -5.17 -0.3 4.59e-7 Gut microbiota (bacterial taxa); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18163118 chr11:67250585 AIP -0.45 -6.08 -0.35 4.26e-9 Fibrinogen levels; CESC cis rs2404602 0.692 rs4886829 chr15:77091182 G/T cg22467129 chr15:76604101 ETFA -0.34 -5.17 -0.3 4.62e-7 Blood metabolite levels; CESC cis rs71636778 0.543 rs12749822 chr1:27221963 T/C cg12203394 chr1:27248618 NUDC 0.68 5.58 0.32 6.01e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs2296225 0.722 rs74840517 chr1:21049848 G/A cg24673385 chr1:21051448 SH2D5 0.34 5.51 0.32 8.61e-8 Eosinophilic esophagitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00162541 chr19:16607016 C19orf44;CALR3 -0.54 -6.07 -0.35 4.38e-9 Gut microbiome composition (summer); CESC cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.4 0.41 1.78e-12 Tonsillectomy; CESC cis rs1620921 0.524 rs12214168 chr6:161195801 C/T cg01280913 chr6:161186852 NA -0.4 -6.12 -0.35 3.42e-9 Lipoprotein (a) - cholesterol levels; CESC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs2204008 0.713 rs12366709 chr12:38210179 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs6088590 0.561 rs6059932 chr20:33175466 C/T cg06115741 chr20:33292138 TP53INP2 0.51 6.53 0.37 3.27e-10 Coronary artery disease; CESC cis rs1348850 0.914 rs4893957 chr2:178380409 A/G cg23306229 chr2:178417860 TTC30B 0.65 8.07 0.44 2.52e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 7.13 0.4 9.81e-12 Electroencephalogram traits; CESC cis rs10504229 0.516 rs4361758 chr8:57990401 C/T cg22535103 chr8:58192502 C8orf71 -0.48 -5.89 -0.34 1.16e-8 Developmental language disorder (linguistic errors); CESC cis rs1215050 0.740 rs2555390 chr4:98999112 A/G cg05340658 chr4:99064831 C4orf37 -0.57 -7.62 -0.42 4.43e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs6500602 0.702 rs11076834 chr16:4549583 C/G cg08645402 chr16:4508243 NA 0.51 8.22 0.45 9.18e-15 Schizophrenia; CESC cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg04455712 chr21:45112962 RRP1B 0.39 5.68 0.33 3.58e-8 Mean corpuscular volume; CESC cis rs9549367 0.789 rs71446682 chr13:113894908 A/G cg18105134 chr13:113819100 PROZ -0.66 -7.97 -0.44 4.85e-14 Platelet distribution width; CESC cis rs11958404 1.000 rs56175756 chr5:157391080 T/C cg05962755 chr5:157440814 NA 0.57 6.14 0.35 2.98e-9 IgG glycosylation; CESC cis rs2635047 0.601 rs2684842 chr18:44725289 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.43 -5.93 -0.34 9.19e-9 Educational attainment; CESC cis rs9300255 0.602 rs1790131 chr12:123701010 G/T cg05973401 chr12:123451056 ABCB9 0.49 5.63 0.33 4.65e-8 Neutrophil percentage of white cells; CESC cis rs7089973 0.604 rs35319791 chr10:116602296 C/A cg23260525 chr10:116636907 FAM160B1 0.4 7.2 0.4 6.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7582720 1.000 rs72936852 chr2:203775475 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.6 0.38 2.21e-10 Bipolar disorder; CESC cis rs9611565 0.838 rs4239894 chr22:41745548 C/G cg06481639 chr22:41940642 POLR3H -0.68 -7.28 -0.41 3.84e-12 Vitiligo; CESC cis rs3747547 0.642 rs112575018 chr9:38080747 G/A cg13774184 chr9:37916125 SHB -0.58 -5.38 -0.31 1.65e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.98 14.98 0.68 3.54e-37 Subjective well-being; CESC cis rs7429990 0.932 rs4293721 chr3:48045137 C/A cg11946769 chr3:48343235 NME6 -0.44 -5.38 -0.31 1.63e-7 Educational attainment (years of education); CESC cis rs7193541 0.646 rs7188880 chr16:74664810 A/T cg01733217 chr16:74700730 RFWD3 1.06 20.86 0.79 7.73e-58 Multiple myeloma; CESC cis rs11098499 0.954 rs11729521 chr4:120416788 T/C cg24375607 chr4:120327624 NA 0.46 5.66 0.33 3.97e-8 Corneal astigmatism; CESC cis rs2380220 0.574 rs9400526 chr6:95998441 T/C cg04719120 chr6:96025338 MANEA 0.47 5.39 0.31 1.6e-7 Behavioural disinhibition (generation interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11664379 chr5:7289931 NA -0.44 -6.83 -0.39 5.8e-11 Gut microbiota (bacterial taxa); CESC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg04248312 chr19:17393744 ANKLE1 -0.96 -15.14 -0.68 9.45e-38 Systemic lupus erythematosus; CESC cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg00033643 chr7:134001901 SLC35B4 0.42 5.47 0.32 1.04e-7 Mean platelet volume; CESC cis rs561341 1.000 rs7210970 chr17:30262169 G/A cg19193384 chr17:30244184 NA -0.48 -5.52 -0.32 8.2e-8 Hip circumference adjusted for BMI; CESC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.86 -0.34 1.38e-8 Total body bone mineral density; CESC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg24881330 chr22:46731750 TRMU 0.87 7.23 0.41 5.11e-12 LDL cholesterol;Cholesterol, total; CESC cis rs703842 0.739 rs701008 chr12:58117645 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.46 5.78 0.33 2.12e-8 Multiple sclerosis; CESC cis rs1385374 1.000 rs12311303 chr12:129301592 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 0.6 5.22 0.31 3.61e-7 Systemic lupus erythematosus; CESC cis rs6582630 0.599 rs4882313 chr12:38454011 G/A cg26384229 chr12:38710491 ALG10B -0.44 -5.96 -0.34 7.9e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7631605 0.967 rs4678950 chr3:37253682 C/T cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.11 -0.3 6.25e-7 Cerebrospinal P-tau181p levels; CESC cis rs8058578 0.943 rs7197770 chr16:30715908 T/C cg02466173 chr16:30829666 NA -0.4 -6.36 -0.36 8.58e-10 Multiple myeloma; CESC cis rs3087591 1.000 rs12939853 chr17:29455021 G/A cg24425628 chr17:29625626 OMG;NF1 0.42 5.17 0.3 4.57e-7 Hip circumference; CESC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs6815814 0.950 rs11725779 chr4:38811668 G/A cg02016764 chr4:38805732 TLR1 -0.62 -7.43 -0.42 1.5e-12 Breast cancer; CESC cis rs4148883 0.689 rs2851275 chr4:100024883 A/G cg12011299 chr4:100065546 ADH4 0.65 9.73 0.51 2.53e-19 Alcohol dependence; CESC cis rs2859741 0.967 rs507460 chr1:37493206 C/G cg09363841 chr1:37513479 NA 0.65 10.56 0.54 5.51e-22 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs7247513 0.930 rs35275129 chr19:12716493 G/A cg01871581 chr19:12707946 ZNF490 -0.89 -15.19 -0.68 6.69e-38 Bipolar disorder; CESC cis rs9322193 0.884 rs9383865 chr6:150173179 A/G cg13206674 chr6:150067644 NUP43 0.38 5.12 0.3 5.81e-7 Lung cancer; CESC cis rs782590 0.805 rs782578 chr2:55915904 A/C cg18811423 chr2:55921094 PNPT1 0.8 12.89 0.62 7.51e-30 Metabolic syndrome; CESC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.07e-8 Lung cancer; CESC cis rs2979489 0.891 rs4285443 chr8:30327317 A/G cg26383811 chr8:30366931 RBPMS -0.81 -10.05 -0.53 2.37e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs6570726 0.846 rs446031 chr6:145885592 C/T cg23711669 chr6:146136114 FBXO30 0.82 12.1 0.6 3.84e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs3733585 0.674 rs7375643 chr4:9955239 A/G cg00071950 chr4:10020882 SLC2A9 -0.78 -14.48 -0.66 2.06e-35 Cleft plate (environmental tobacco smoke interaction); CESC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg18252515 chr7:66147081 NA 0.39 5.08 0.3 7.05e-7 Aortic root size; CESC cis rs6598955 0.670 rs4659366 chr1:26542572 G/A cg19743891 chr1:26644573 UBXN11;CD52 -0.26 -5.12 -0.3 5.98e-7 Obesity-related traits; CESC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.83 -9.22 -0.49 9.93e-18 Gut microbiome composition (summer); CESC cis rs9467773 0.549 rs9461273 chr6:26584526 A/G cg11502198 chr6:26597334 ABT1 -0.4 -5.66 -0.33 3.88e-8 Intelligence (multi-trait analysis); CESC cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg15017067 chr4:17643749 FAM184B 0.37 5.21 0.3 3.74e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg06873352 chr17:61820015 STRADA -0.74 -13.42 -0.64 1.08e-31 Prudent dietary pattern; CESC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg17724175 chr1:150552817 MCL1 0.44 7.23 0.41 5.25e-12 Tonsillectomy; CESC cis rs1348850 0.567 rs2222711 chr2:178534110 G/T cg22681709 chr2:178499509 PDE11A -0.5 -7.37 -0.41 2.21e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg08859206 chr1:53392774 SCP2 0.51 6.88 0.39 4.34e-11 Monocyte count; CESC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.64 -0.51 4.86e-19 Alzheimer's disease; CESC cis rs892961 0.965 rs2411111 chr17:75402540 A/T cg05865280 chr17:75406074 SEPT9 0.59 11.23 0.57 3.53e-24 Airflow obstruction; CESC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg18252515 chr7:66147081 NA -0.48 -6.45 -0.37 5.25e-10 Aortic root size; CESC cis rs6665290 0.835 rs11578479 chr1:227210888 A/T cg10327440 chr1:227177885 CDC42BPA -1.16 -24.11 -0.83 8.77e-69 Myeloid white cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17098857 chr11:82556674 PRCP -0.58 -6.8 -0.39 7.05e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17201535 chr8:145140563 GPAA1 -0.57 -6.51 -0.37 3.71e-10 Gut microbiome composition (summer); CESC cis rs4481887 0.741 rs6587462 chr1:248539094 C/T cg26353448 chr1:248524236 OR2T4 0.36 5.11 0.3 6.32e-7 Common traits (Other); CESC cis rs9911578 0.967 rs11079354 chr17:56594460 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10801419 chr12:120632649 GCN1L1 0.58 6.25 0.36 1.62e-9 Gut microbiome composition (summer); CESC cis rs8002861 0.846 rs12869355 chr13:44478193 A/C cg14210620 chr13:44453864 C13orf31;CCDC122 0.42 5.41 0.32 1.44e-7 Leprosy; CESC cis rs9611565 0.525 rs9611548 chr22:41704143 G/T cg06634786 chr22:41940651 POLR3H -0.49 -5.09 -0.3 6.88e-7 Vitiligo; CESC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg27165867 chr14:105738592 BRF1 -0.54 -5.87 -0.34 1.31e-8 Mean platelet volume;Platelet distribution width; CESC cis rs6502050 0.835 rs9901076 chr17:80170020 G/A cg01763666 chr17:80159506 CCDC57 -0.36 -5.04 -0.3 8.74e-7 Life satisfaction; CESC cis rs1413885 0.549 rs7545720 chr1:65856443 G/T cg14976592 chr1:65886160 LEPROT;LEPR 0.48 6.41 0.37 6.8e-10 Anticoagulant levels; CESC cis rs7762018 0.943 rs7772889 chr6:170142458 T/C cg13891659 chr6:170190454 C6orf122;C6orf208 0.67 6.66 0.38 1.61e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs34779708 0.897 rs7897827 chr10:35386237 C/T cg04310649 chr10:35416472 CREM -0.53 -6.52 -0.37 3.46e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs10489896 0.541 rs11578044 chr1:234580945 G/T cg10395685 chr11:86085715 CCDC81 -0.43 -6.38 -0.36 7.97e-10 Cognitive test performance; CESC trans rs4906172 0.773 rs1190612 chr14:102520888 A/G cg17920195 chr4:129149383 NA 0.31 6.01 0.35 5.99e-9 Menopause (age at onset); CESC cis rs67311347 0.524 rs11129869 chr3:40259738 G/A cg09455208 chr3:40491958 NA 0.35 5.5 0.32 9.03e-8 Renal cell carcinoma; CESC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg07507251 chr3:52567010 NT5DC2 0.42 7.2 0.4 6.24e-12 Bipolar disorder; CESC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.43 0.42 1.45e-12 Prudent dietary pattern; CESC cis rs7216064 0.765 rs6504550 chr17:65894542 A/G cg07042672 chr17:66097459 LOC651250 -0.56 -7.54 -0.42 7.47e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs3096299 0.728 rs1011749 chr16:89510869 G/C cg02034447 chr16:89574710 SPG7 0.47 6.06 0.35 4.7e-9 Multiple myeloma (IgH translocation); CESC cis rs9611565 0.506 rs2024566 chr22:41697338 A/G cg06481639 chr22:41940642 POLR3H -0.52 -5.74 -0.33 2.57e-8 Vitiligo; CESC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg18190219 chr22:46762943 CELSR1 -0.59 -6.7 -0.38 1.23e-10 LDL cholesterol;Cholesterol, total; CESC cis rs7927771 0.524 rs7929014 chr11:47776283 C/T cg20307385 chr11:47447363 PSMC3 0.61 8.59 0.47 7.41e-16 Subjective well-being; CESC cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC trans rs28549925 0.590 rs9690302 chr7:16986964 C/T cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.83e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs9549367 0.673 rs3024735 chr13:113819513 G/A cg18105134 chr13:113819100 PROZ -0.65 -7.7 -0.43 2.77e-13 Platelet distribution width; CESC cis rs5758659 0.714 rs5751216 chr22:42508937 G/T cg00645731 chr22:42541494 CYP2D7P1 0.31 5.39 0.31 1.55e-7 Cognitive function; CESC cis rs798554 0.704 rs798531 chr7:2770067 G/C cg09658497 chr7:2847517 GNA12 -0.36 -5.41 -0.32 1.38e-7 Height; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09799789 chr1:245836746 KIF26B -0.51 -6.9 -0.39 3.91e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg11764359 chr7:65958608 NA 0.66 8.54 0.46 1.08e-15 Calcium levels; CESC cis rs9611565 0.921 rs4822021 chr22:41726053 G/A cg17376030 chr22:41985996 PMM1 0.5 5.46 0.32 1.1e-7 Vitiligo; CESC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg27572855 chr1:25598939 RHD 0.43 7.22 0.41 5.42e-12 Erythrocyte sedimentation rate; CESC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 6.3 0.36 1.26e-9 LDL cholesterol;Cholesterol, total; CESC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg11764359 chr7:65958608 NA 0.63 8.98 0.48 5.3e-17 Aortic root size; CESC cis rs2635047 0.811 rs12956009 chr18:44768024 T/C cg19077165 chr18:44547161 KATNAL2 -0.39 -5.11 -0.3 6.12e-7 Educational attainment; CESC cis rs6120849 0.663 rs6119548 chr20:33552612 A/G cg06115741 chr20:33292138 TP53INP2 0.53 5.04 0.3 8.81e-7 Protein C levels; CESC cis rs3749237 0.595 rs1464566 chr3:49459376 T/C cg02487422 chr3:49467188 NICN1 0.57 8.33 0.46 4.42e-15 Resting heart rate; CESC cis rs2882667 0.858 rs10900856 chr5:138417746 C/T cg04439458 chr5:138467593 SIL1 0.4 6.32 0.36 1.08e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.49 -6.06 -0.35 4.66e-9 Tonsillectomy; CESC trans rs4942242 0.640 rs9533571 chr13:44230136 C/T cg19169023 chr15:41853346 TYRO3 -0.6 -7.8 -0.43 1.41e-13 Response to tocilizumab in rheumatoid arthritis; CESC cis rs10883723 0.773 rs11191313 chr10:104278618 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.49 5.38 0.31 1.62e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs6831352 0.918 rs29001211 chr4:100051941 C/T cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs12541635 0.677 rs62527405 chr8:107058109 G/C cg10147462 chr8:107024639 NA 0.43 6.41 0.37 6.55e-10 Age of smoking initiation; CESC cis rs854765 0.647 rs7211714 chr17:17986955 A/G cg04398451 chr17:18023971 MYO15A -0.76 -11.15 -0.57 6.33e-24 Total body bone mineral density; CESC cis rs365132 0.905 rs10068703 chr5:176377069 T/A cg16309518 chr5:176445507 NA -0.37 -5.36 -0.31 1.83e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg18876405 chr7:65276391 NA -0.5 -5.84 -0.34 1.55e-8 Aortic root size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06493554 chr7:134001556 SLC35B4 -0.51 -6.33 -0.36 1.04e-9 Ulcerative colitis; CESC cis rs66561647 0.895 rs9649959 chr8:128972721 C/T cg05480350 chr8:128972681 MIR1205;PVT1 -0.57 -8.39 -0.46 2.88e-15 Hemoglobin concentration; CESC cis rs1062177 1.000 rs12654573 chr5:151207473 T/G cg12924095 chr5:151150029 G3BP1 0.43 5.61 0.33 5.12e-8 Preschool internalizing problems; CESC cis rs3820068 0.603 rs998032 chr1:15989918 T/C cg13390004 chr1:15929781 NA 0.34 5.51 0.32 8.39e-8 Systolic blood pressure; CESC cis rs35306767 0.903 rs11253504 chr10:956046 A/G cg25019033 chr10:957182 NA -0.6 -6.42 -0.37 6.2e-10 Eosinophil percentage of granulocytes; CESC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs6460942 0.597 rs12699381 chr7:12527026 G/A cg20607287 chr7:12443886 VWDE -0.71 -7.7 -0.43 2.69e-13 Coronary artery disease; CESC cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs61776719 0.520 rs17465651 chr1:38418496 C/T cg04673462 chr1:38461896 NA 0.4 6.09 0.35 3.99e-9 Coronary artery disease; CESC cis rs1577917 0.654 rs9450284 chr6:86199329 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.47 6.79 0.38 7.37e-11 Response to antipsychotic treatment; CESC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.36 0.36 9.03e-10 Bipolar disorder; CESC cis rs4243830 0.850 rs2063806 chr1:6610382 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -8.42 -0.46 2.37e-15 Body mass index; CESC cis rs6088580 0.524 rs2378251 chr20:33276750 C/T cg07148914 chr20:33460835 GGT7 -0.41 -5.26 -0.31 2.96e-7 Glomerular filtration rate (creatinine); CESC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg11890956 chr21:40555474 PSMG1 -0.98 -16.55 -0.71 9.7e-43 Cognitive function; CESC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg02038168 chr22:39784481 NA -0.62 -7.79 -0.43 1.56e-13 Intelligence (multi-trait analysis); CESC cis rs11969893 0.655 rs67724651 chr6:101417004 T/G cg12253828 chr6:101329408 ASCC3 0.92 6.04 0.35 5.3e-9 Economic and political preferences (immigration/crime); CESC cis rs7713065 0.765 rs11741543 chr5:131771315 G/T cg10809880 chr5:131517096 NA -0.46 -5.2 -0.3 3.92e-7 Lung function (FEV1/FVC); CESC cis rs3793683 0.597 rs12783367 chr10:134587334 T/C cg27286337 chr10:134555280 INPP5A 0.7 8.14 0.45 1.6e-14 Migraine; CESC cis rs9300255 0.602 rs1716167 chr12:123651162 C/T cg19016782 chr12:123741754 C12orf65 0.41 5.84 0.34 1.53e-8 Neutrophil percentage of white cells; CESC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg11890956 chr21:40555474 PSMG1 -0.94 -15.31 -0.69 2.48e-38 Cognitive function; CESC cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg04450456 chr4:17643702 FAM184B 0.4 5.78 0.33 2.13e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg11890956 chr21:40555474 PSMG1 1.14 18.45 0.75 1.9e-49 Cognitive function; CESC cis rs2404602 0.647 rs4886840 chr15:77179002 A/G cg23625390 chr15:77176239 SCAPER -0.45 -6.25 -0.36 1.68e-9 Blood metabolite levels; CESC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg23262073 chr20:60523788 NA -0.54 -7.45 -0.42 1.35e-12 Obesity-related traits; CESC cis rs2439831 0.867 rs12323999 chr15:43683115 T/A cg02155558 chr15:43621948 ADAL;LCMT2 0.86 13.11 0.63 1.3e-30 Lung cancer in ever smokers; CESC cis rs897984 0.645 rs9938550 chr16:30999142 A/G cg02466173 chr16:30829666 NA 0.5 8.44 0.46 2.11e-15 Dementia with Lewy bodies; CESC cis rs10752881 1.000 rs10797808 chr1:182979623 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Colorectal cancer; CESC cis rs62283056 0.512 rs4568307 chr4:6284965 A/G cg25554036 chr4:6271136 WFS1 0.52 7.21 0.41 5.76e-12 Cisplatin-induced ototoxicity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07116015 chr17:27046591 RAB34;SNORD42B;RPL23A 0.63 7.03 0.4 1.8e-11 Gut microbiome composition (summer); CESC cis rs8072100 0.840 rs9893901 chr17:45506682 T/G cg08085267 chr17:45401833 C17orf57 -0.53 -7.16 -0.4 7.96e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.8 0.48 1.79e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6740322 0.748 rs1549723 chr2:43460514 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.78 -8.38 -0.46 3.08e-15 Coronary artery disease; CESC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs1005277 0.505 rs10827836 chr10:38215441 A/G cg25427524 chr10:38739819 LOC399744 0.71 10.67 0.55 2.33e-22 Extrinsic epigenetic age acceleration; CESC trans rs11098499 0.754 rs12506610 chr4:120241659 T/C cg25214090 chr10:38739885 LOC399744 0.61 8.47 0.46 1.73e-15 Corneal astigmatism; CESC cis rs1670533 1.000 rs11247971 chr4:1053580 A/G cg04106633 chr4:1044584 NA 0.41 5.2 0.3 3.94e-7 Recombination rate (females); CESC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg05368731 chr17:41323189 NBR1 0.8 11.13 0.56 7.38e-24 Menopause (age at onset); CESC cis rs6121246 0.529 rs6060118 chr20:30171209 T/C cg13852791 chr20:30311386 BCL2L1 0.7 7.17 0.4 7.61e-12 Mean corpuscular hemoglobin; CESC cis rs644799 0.710 rs564480 chr11:95561741 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.78 11.15 0.57 6.38e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs71403859 0.502 rs12927456 chr16:71505706 A/G cg08717414 chr16:71523259 ZNF19 -1.02 -9.58 -0.51 7.51e-19 Post bronchodilator FEV1; CESC cis rs2380220 0.720 rs9374178 chr6:95979974 G/T cg23517279 chr6:96025343 MANEA 0.53 5.63 0.33 4.68e-8 Behavioural disinhibition (generation interaction); CESC cis rs10870270 1.000 rs10870232 chr10:133738537 T/G cg26149184 chr10:133730230 NA 0.37 5.06 0.3 7.88e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs13118159 0.641 rs4974598 chr4:1313220 C/T cg19318889 chr4:1322082 MAEA 0.45 6.04 0.35 5.09e-9 Longevity; CESC cis rs854765 1.000 rs854765 chr17:18012730 T/C cg09796270 chr17:17721594 SREBF1 -0.38 -5.04 -0.3 8.65e-7 Total body bone mineral density; CESC cis rs2228479 0.867 rs73276534 chr16:89950557 A/G cg06558623 chr16:89946397 TCF25 0.6 5.98 0.34 7.29e-9 Skin colour saturation; CESC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg19774624 chr17:42201019 HDAC5 -0.9 -14.92 -0.68 5.71e-37 Total body bone mineral density; CESC cis rs11579220 1 rs11579220 chr1:205144363 G/T cg00857998 chr1:205179979 DSTYK 0.56 7.2 0.4 6.3e-12 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs116095464 0.510 rs55750776 chr5:230467 T/C cg22857025 chr5:266934 NA -1.28 -18.8 -0.76 1.06e-50 Breast cancer; CESC cis rs829883 1.000 rs829883 chr12:98879606 G/A cg25150519 chr12:98850993 NA 0.68 9.06 0.49 2.94e-17 Colorectal adenoma (advanced); CESC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg02038168 chr22:39784481 NA -0.64 -7.42 -0.41 1.63e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs6580649 0.882 rs7133249 chr12:48456823 C/T cg24011408 chr12:48396354 COL2A1 -0.42 -5.28 -0.31 2.67e-7 Lung cancer; CESC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.13 22.21 0.81 1.93e-62 Prudent dietary pattern; CESC cis rs3733585 0.673 rs7375587 chr4:9954758 A/T cg00071950 chr4:10020882 SLC2A9 0.72 11.94 0.59 1.37e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4819052 0.590 rs414743 chr21:46512075 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.58 6.36 0.36 8.66e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9911578 0.935 rs117819974 chr17:57002324 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.28 0.31 2.68e-7 Intelligence (multi-trait analysis); CESC cis rs10751667 0.666 rs7124480 chr11:971601 G/A cg20946044 chr11:1010712 AP2A2 -0.39 -5.33 -0.31 2.09e-7 Alzheimer's disease (late onset); CESC cis rs2295359 0.892 rs72676067 chr1:67658803 G/A cg17031739 chr1:67600172 NA 0.4 5.25 0.31 3.18e-7 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08822737 chr17:71088851 SLC39A11 0.68 7.69 0.43 2.93e-13 Gut microbiome composition (summer); CESC cis rs17376456 0.877 rs10073039 chr5:93467709 A/G cg25358565 chr5:93447407 FAM172A 1.15 11.35 0.57 1.34e-24 Diabetic retinopathy; CESC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.48 0.42 1.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.649 rs202666 chr22:41814719 T/C cg17376030 chr22:41985996 PMM1 -0.62 -6.64 -0.38 1.79e-10 Vitiligo; CESC cis rs67311347 1.000 rs11716675 chr3:40485280 G/T cg09455208 chr3:40491958 NA 0.44 7.54 0.42 7.53e-13 Renal cell carcinoma; CESC cis rs9300255 0.602 rs1790126 chr12:123683563 C/T cg00376283 chr12:123451042 ABCB9 0.71 8.92 0.48 7.69e-17 Neutrophil percentage of white cells; CESC cis rs2204008 0.806 rs35534445 chr12:38279093 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.24 0.53 5.85e-21 Bladder cancer; CESC cis rs6460942 0.818 rs116613169 chr7:12234669 T/C cg20607287 chr7:12443886 VWDE -0.59 -5.78 -0.33 2.05e-8 Coronary artery disease; CESC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.13 -0.3 5.55e-7 Obesity-related traits; CESC cis rs6582630 0.555 rs61932279 chr12:38349096 C/T cg26384229 chr12:38710491 ALG10B -0.43 -5.57 -0.32 6.1e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg16405210 chr4:1374714 KIAA1530 0.76 10.61 0.55 3.67e-22 Obesity-related traits; CESC cis rs17818399 0.962 rs2122715 chr2:46845849 A/G cg06386533 chr2:46925753 SOCS5 0.48 5.53 0.32 7.57e-8 Height; CESC cis rs400736 0.894 rs226242 chr1:8033468 G/A cg25007680 chr1:8021821 PARK7 0.72 10.25 0.53 5.36e-21 Response to antidepressants and depression; CESC cis rs9611565 0.559 rs4822049 chr22:41993496 G/A cg03806693 chr22:41940476 POLR3H -1.16 -13.06 -0.63 1.99e-30 Vitiligo; CESC cis rs3857067 1.000 rs2865332 chr4:95013858 C/G cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.53 -0.42 8.12e-13 QT interval; CESC cis rs116988415 0.584 rs75851540 chr14:65262909 C/T cg25083366 chr14:65239357 SPTB 0.73 5.21 0.3 3.74e-7 Daytime sleep phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04269641 chr17:42422442 GRN -0.55 -6.19 -0.36 2.26e-9 Gut microbiome composition (summer); CESC cis rs921968 0.591 rs6717107 chr2:219588697 A/G cg02176678 chr2:219576539 TTLL4 -0.43 -7.59 -0.42 5.51e-13 Mean corpuscular hemoglobin concentration; CESC cis rs7762018 0.607 rs75964125 chr6:170054290 T/A cg19338460 chr6:170058176 WDR27 -0.74 -6.34 -0.36 9.84e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9868809 0.772 rs9809222 chr3:48714411 C/T cg06212747 chr3:49208901 KLHDC8B -0.6 -5.19 -0.3 4.29e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs10788264 0.544 rs911786 chr10:124017583 C/G cg09507567 chr10:124027408 NA 0.42 5.81 0.34 1.82e-8 Total body bone mineral density; CESC cis rs17376456 0.877 rs34673483 chr5:93315079 C/A cg21475434 chr5:93447410 FAM172A 0.75 6.65 0.38 1.67e-10 Diabetic retinopathy; CESC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg17971929 chr21:40555470 PSMG1 -0.52 -6.67 -0.38 1.49e-10 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21959036 chr4:129733057 PHF17 0.59 6.74 0.38 1e-10 Gut microbiome composition (summer); CESC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg27121462 chr16:89883253 FANCA 0.8 11.72 0.58 7.88e-26 Vitiligo; CESC cis rs854765 0.583 rs4244602 chr17:17841456 A/G cg04398451 chr17:18023971 MYO15A -0.66 -9.22 -0.49 9.48e-18 Total body bone mineral density; CESC cis rs10751667 0.666 rs6597966 chr11:950750 T/C cg20946044 chr11:1010712 AP2A2 -0.37 -5.08 -0.3 7.09e-7 Alzheimer's disease (late onset); CESC cis rs10242455 0.702 rs41385645 chr7:98974038 A/T cg25640893 chr7:99214727 ZNF498 0.87 5.77 0.33 2.15e-8 Blood metabolite levels; CESC cis rs7843479 0.582 rs11779655 chr8:21794041 A/G cg17168535 chr8:21777572 XPO7 -0.74 -12.43 -0.61 2.91e-28 Mean corpuscular volume; CESC cis rs208520 1.000 rs12193164 chr6:66978962 C/T cg07460842 chr6:66804631 NA 0.88 10.14 0.53 1.22e-20 Exhaled nitric oxide output; CESC cis rs9937943 0.667 rs9938426 chr16:74523739 C/G cg01733217 chr16:74700730 RFWD3 -0.61 -5.49 -0.32 9.2e-8 Neutrophil percentage of white cells; CESC cis rs807669 0.525 rs2073740 chr22:19196112 A/C cg02655711 chr22:19163373 SLC25A1 -0.43 -6.49 -0.37 4.16e-10 Metabolite levels; CESC cis rs644799 0.648 rs1255181 chr11:95472148 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.45 6.12 0.35 3.39e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4704187 0.687 rs1592948 chr5:74504152 G/A cg03227963 chr5:74354835 NA 0.29 5.27 0.31 2.77e-7 Response to amphetamines; CESC cis rs1005277 0.579 rs1780145 chr10:38537070 A/G cg00409905 chr10:38381863 ZNF37A -0.51 -6.77 -0.38 8.46e-11 Extrinsic epigenetic age acceleration; CESC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg09365446 chr1:150670422 GOLPH3L 0.41 5.75 0.33 2.5e-8 Tonsillectomy; CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.35 5.18 0.3 4.33e-7 Electroencephalogram traits; CESC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg22638593 chr5:131593259 PDLIM4 0.39 5.1 0.3 6.34e-7 Breast cancer; CESC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -6.7 -0.38 1.27e-10 Total body bone mineral density; CESC cis rs2404602 0.684 rs1011084 chr15:77007480 C/G cg23625390 chr15:77176239 SCAPER -0.4 -5.2 -0.3 4e-7 Blood metabolite levels; CESC trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg03929089 chr4:120376271 NA -0.93 -15.61 -0.69 2.13e-39 Height; CESC cis rs4253772 0.591 rs6520010 chr22:46721223 G/A cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.57 5.91 0.34 1.07e-8 LDL cholesterol;Cholesterol, total; CESC cis rs870825 0.616 rs1401359 chr4:185640216 T/C cg04058563 chr4:185651563 MLF1IP 0.66 7.21 0.4 5.94e-12 Blood protein levels; CESC cis rs2477686 0.526 rs2477690 chr1:2395563 G/A cg07700843 chr1:2391317 NA -0.43 -7.23 -0.41 5.22e-12 Non-obstructive azoospermia; CESC cis rs1395 0.813 rs11685326 chr2:27453679 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.45 5.93 0.34 9.64e-9 Blood metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11702503 chr19:6215254 MLLT1 0.51 6.89 0.39 4.04e-11 Fibrinogen levels; CESC cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg05340658 chr4:99064831 C4orf37 0.84 13.04 0.63 2.35e-30 Colonoscopy-negative controls vs population controls; CESC cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg08885076 chr2:99613938 TSGA10 -0.38 -5.06 -0.3 7.82e-7 Chronic sinus infection; CESC cis rs35955747 0.869 rs28715 chr22:31730169 C/T cg02404636 chr22:31891804 SFI1 0.37 5.14 0.3 5.31e-7 Neutrophil count;Sum basophil neutrophil counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05918473 chr13:32885580 ZAR1L -0.51 -6.22 -0.36 1.88e-9 Gut microbiome composition (summer); CESC trans rs4363385 0.626 rs11205192 chr1:153062767 C/T cg25629905 chr12:26273008 BHLHE41 0.35 6.04 0.35 5.3e-9 Inflammatory skin disease; CESC cis rs5758659 0.714 rs6002607 chr22:42496506 C/T cg19513890 chr22:42538836 CYP2D7P1 0.38 5.63 0.33 4.62e-8 Cognitive function; CESC cis rs524023 0.914 rs555456 chr11:64418259 T/C cg07220939 chr11:64358617 SLC22A12 -0.35 -5.32 -0.31 2.23e-7 Urate levels in obese individuals; CESC cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17537009 chr12:118814304 SUDS3 0.56 6.52 0.37 3.46e-10 Gut microbiome composition (summer); CESC cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg22875332 chr1:76189707 ACADM 0.65 6.44 0.37 5.54e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7904368 1.000 rs7904368 chr10:16858587 C/T cg23933602 chr10:16859644 RSU1 0.77 9.41 0.5 2.5e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs6141600 0.540 rs1006296 chr20:34717718 T/C cg07747181 chr20:34652970 NA -0.37 -5.18 -0.3 4.5e-7 Height;Hip circumference; CESC cis rs7078219 0.505 rs7893840 chr10:101293341 T/C cg09788492 chr10:101292477 NKX2-3 0.32 5.99 0.35 6.65e-9 Dental caries; CESC cis rs9595066 0.548 rs9562537 chr13:44755787 G/A cg04068111 chr13:44716778 NA -0.46 -5.92 -0.34 1.02e-8 Schizophrenia; CESC cis rs57506017 0.585 rs2356065 chr7:12276885 T/C cg23422036 chr7:12250390 TMEM106B 0.39 5.21 0.3 3.84e-7 Neuroticism; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg08043571 chr20:48100962 NA 0.5 6.13 0.35 3.18e-9 Psoriatic arthritis; CESC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg18765753 chr7:1198926 ZFAND2A -0.39 -5.94 -0.34 8.72e-9 Longevity;Endometriosis; CESC cis rs4319547 0.728 rs61954974 chr12:123074169 T/C cg05707623 chr12:122985044 ZCCHC8 -0.58 -6.75 -0.38 9.5e-11 Body mass index; CESC trans rs116095464 0.558 rs2162870 chr5:228129 G/A cg00938859 chr5:1591904 SDHAP3 0.61 6.74 0.38 9.82e-11 Breast cancer; CESC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg22143856 chr6:28129313 ZNF389 0.52 6.77 0.38 8.31e-11 Depression; CESC cis rs3008870 0.958 rs12131222 chr1:67438535 A/T cg02640540 chr1:67518911 SLC35D1 -0.51 -5.58 -0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg08392591 chr16:89556376 ANKRD11 0.58 7.96 0.44 5.01e-14 Multiple myeloma (IgH translocation); CESC cis rs68092024 0.731 rs792840 chr3:99471251 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.42 6.77 0.38 8.49e-11 Cleft lip with or without cleft palate; CESC trans rs28549925 0.590 rs1403802 chr7:16989793 G/C cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.83e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs4523957 0.928 rs8066372 chr17:2180968 A/G cg16513277 chr17:2031491 SMG6 -0.6 -8.21 -0.45 9.51e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22541143 chr4:84377292 HELQ;MRPS18C 0.61 7.28 0.41 3.82e-12 Gut microbiome composition (summer); CESC cis rs3733585 0.699 rs6449157 chr4:9960442 G/A cg00071950 chr4:10020882 SLC2A9 -0.73 -11.91 -0.59 1.82e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8005677 0.828 rs3794452 chr14:23386682 T/G cg25600027 chr14:23388339 RBM23 -0.4 -5.04 -0.3 8.56e-7 Cognitive ability (multi-trait analysis); CESC cis rs6987853 0.931 rs2923432 chr8:42395632 G/C cg09913449 chr8:42400586 C8orf40 0.37 5.77 0.33 2.18e-8 Mean corpuscular hemoglobin concentration; CESC cis rs1957429 0.901 rs17102320 chr14:65384693 T/C cg23373153 chr14:65346875 NA -0.9 -9.7 -0.51 3.21e-19 Pediatric areal bone mineral density (radius); CESC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg17366294 chr4:99064904 C4orf37 0.58 8.25 0.45 7.41e-15 Colonoscopy-negative controls vs population controls; CESC cis rs3806843 0.900 rs116210441 chr5:140128649 T/A cg26395211 chr5:140044315 WDR55 0.39 5.14 0.3 5.47e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7666738 0.710 rs7674407 chr4:98838522 A/G cg17366294 chr4:99064904 C4orf37 0.52 6.92 0.39 3.36e-11 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg05861140 chr6:150128134 PCMT1 -0.35 -5.11 -0.3 6.19e-7 Lung cancer; CESC cis rs4722166 0.508 rs2069832 chr7:22767433 A/G cg05265849 chr7:22767390 IL6 0.5 6.5 0.37 3.86e-10 Lung cancer; CESC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.91 -11.23 -0.57 3.39e-24 Gut microbiome composition (summer); CESC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg18761221 chr20:60518478 NA 0.38 5.13 0.3 5.69e-7 Body mass index; CESC trans rs9784649 0.760 rs17343923 chr5:25052414 G/A cg08600765 chr20:34638493 LOC647979 -0.58 -6.28 -0.36 1.39e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs3096299 0.967 rs7205785 chr16:89458984 A/G cg16743903 chr16:89593216 SPG7 -0.41 -5.25 -0.31 3.05e-7 Multiple myeloma (IgH translocation); CESC cis rs6942756 0.513 rs10954224 chr7:128893513 T/A cg02491457 chr7:128862824 NA 0.5 7.3 0.41 3.41e-12 White matter hyperintensity burden; CESC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.66 -9.68 -0.51 3.53e-19 Age at first birth; CESC cis rs10504229 0.575 rs59424848 chr8:57999219 T/C cg22535103 chr8:58192502 C8orf71 -0.56 -6.58 -0.37 2.48e-10 Developmental language disorder (linguistic errors); CESC cis rs9291683 0.551 rs62295971 chr4:9978142 G/A cg02734326 chr4:10020555 SLC2A9 0.45 6.77 0.38 8.46e-11 Bone mineral density; CESC cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15110300 chr7:45039670 CCM2 -0.5 -6.05 -0.35 4.85e-9 Ulcerative colitis; CESC cis rs763121 0.785 rs5750646 chr22:39013830 T/C cg06544989 chr22:39130855 UNC84B 0.51 9.23 0.49 8.69e-18 Menopause (age at onset); CESC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.76e-18 Skin colour saturation; CESC cis rs7208859 0.562 rs8078897 chr17:29106257 T/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg20476274 chr7:133979776 SLC35B4 0.63 9.08 0.49 2.53e-17 Mean platelet volume; CESC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.13 0.81 3.58e-62 Prudent dietary pattern; CESC cis rs6546537 0.826 rs2704443 chr2:69889338 A/C cg10773587 chr2:69614142 GFPT1 -0.57 -6.77 -0.38 8.37e-11 Serum thyroid-stimulating hormone levels; CESC cis rs7649275 0.882 rs2612026 chr3:53776995 A/G cg21503701 chr3:53781065 CACNA1D -0.4 -5.46 -0.32 1.08e-7 Trans fatty acid levels; CESC cis rs2735413 0.813 rs11644471 chr16:78077237 A/T cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs9300255 0.537 rs1619561 chr12:123620268 G/C cg19016782 chr12:123741754 C12orf65 -0.37 -5.03 -0.3 8.85e-7 Neutrophil percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02567788 chr10:71992279 PPA1 -0.46 -6.41 -0.37 6.64e-10 Gambling; CESC cis rs4906332 1.000 rs17617094 chr14:103893428 T/C cg09975044 chr14:104007538 NA 0.46 6.38 0.36 7.81e-10 Coronary artery disease; CESC cis rs11638352 1.000 rs1808509 chr15:44409539 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.59 -5.42 -0.32 1.33e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg26314531 chr2:26401878 FAM59B -0.61 -6.68 -0.38 1.36e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03576636 chr19:1918189 SCAMP4 -0.56 -6.47 -0.37 4.71e-10 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04293180 chr8:144700367 TSTA3 0.49 6.83 0.39 5.88e-11 Systemic lupus erythematosus; CESC cis rs5769765 0.818 rs8140681 chr22:50292081 C/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.2 -0.3 4.01e-7 Schizophrenia; CESC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.34 0.41 2.56e-12 Tonsillectomy; CESC cis rs11638352 0.661 rs2706486 chr15:44428982 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.55 -5.27 -0.31 2.83e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16724557 chr1:28907903 SNHG12;SNORA44;SNORA16A;SNORA61 -0.55 -6.15 -0.35 2.84e-9 Gut microbiome composition (summer); CESC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg11764359 chr7:65958608 NA 0.67 8.67 0.47 4.39e-16 Aortic root size; CESC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs1198430 0.925 rs487859 chr1:23801101 T/C cg22040403 chr1:23858016 E2F2 0.68 5.5 0.32 9.07e-8 Total cholesterol levels; CESC cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg16144293 chr14:75469539 EIF2B2 0.39 5.1 0.3 6.6e-7 Height; CESC cis rs7923609 0.967 rs7912893 chr10:65162000 T/A cg01631684 chr10:65280961 REEP3 -0.44 -5.48 -0.32 9.84e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg00149659 chr3:10157352 C3orf10 0.99 12.05 0.59 6.02e-27 Alzheimer's disease; CESC cis rs2637266 0.846 rs2637261 chr10:78320593 A/G cg18941641 chr10:78392320 NA -0.38 -6.95 -0.39 2.76e-11 Pulmonary function; CESC cis rs10883723 0.703 rs7898410 chr10:104245858 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.21 0.31 3.72e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg06028605 chr16:24865363 SLC5A11 0.54 8.07 0.44 2.39e-14 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs1814175 0.562 rs1794130 chr11:49903764 T/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs8014204 0.935 rs8010840 chr14:75355203 T/C cg08847533 chr14:75593920 NEK9 -0.46 -5.73 -0.33 2.77e-8 Caffeine consumption; CESC cis rs9872999 1 rs9872999 chr3:133457514 C/T cg24879335 chr3:133465180 TF 0.45 8.68 0.47 4.14e-16 Iron status biomarkers; CESC cis rs7523050 0.643 rs35665867 chr1:109395436 G/A cg08274380 chr1:109419600 GPSM2 0.84 5.42 0.32 1.32e-7 Fat distribution (HIV); CESC cis rs2273669 0.667 rs12201821 chr6:109340291 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.41 -0.37 6.73e-10 Prostate cancer; CESC trans rs4843747 0.671 rs9933794 chr16:88116981 T/C cg26811252 chr16:29126840 RRN3P2 0.69 9.53 0.51 1.05e-18 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11629460 chr3:141457364 RNF7 -0.54 -6.11 -0.35 3.49e-9 Gut microbiome composition (summer); CESC cis rs7582720 0.943 rs72932575 chr2:203866857 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs7726839 0.540 rs61731455 chr5:665295 A/G cg25482853 chr8:67687455 SGK3 0.97 9.73 0.51 2.43e-19 Obesity-related traits; CESC cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg05343316 chr1:45956843 TESK2 -0.52 -6.94 -0.39 3.09e-11 High light scatter reticulocyte count; CESC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg11644478 chr21:40555479 PSMG1 0.96 13.39 0.64 1.44e-31 Cognitive function; CESC cis rs896854 0.517 rs1011796 chr8:95951273 A/G cg09323728 chr8:95962352 TP53INP1 0.36 6.57 0.37 2.64e-10 Type 2 diabetes; CESC cis rs6120849 0.901 rs11696967 chr20:33743609 A/C cg24642439 chr20:33292090 TP53INP2 0.63 6.69 0.38 1.35e-10 Protein C levels; CESC cis rs7726839 0.526 rs11960159 chr5:568685 C/T cg16447950 chr5:562315 NA -0.64 -7.6 -0.42 5.22e-13 Obesity-related traits; CESC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg00934597 chr7:893267 UNC84A 0.53 5.44 0.32 1.19e-7 Cerebrospinal P-tau181p levels; CESC trans rs941207 0.542 rs6581107 chr12:57194981 T/C cg26462586 chr2:11164677 NA 0.38 6.1 0.35 3.74e-9 Platelet count; CESC cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg27398817 chr8:82754497 SNX16 -0.42 -5.32 -0.31 2.24e-7 Diastolic blood pressure; CESC cis rs4319547 0.876 rs10846978 chr12:122964708 T/C cg05707623 chr12:122985044 ZCCHC8 -0.66 -7.7 -0.43 2.64e-13 Body mass index; CESC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.58 0.81 1.09e-63 Prudent dietary pattern; CESC cis rs2760061 0.819 rs708111 chr1:228191365 G/A cg02753203 chr1:228287806 NA 0.52 7.7 0.43 2.71e-13 Diastolic blood pressure; CESC cis rs2204008 0.837 rs8189467 chr12:38241956 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.52 0.32 7.92e-8 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12145552 chr21:43374218 C2CD2 0.66 7.54 0.42 7.66e-13 Gut microbiome composition (summer); CESC cis rs9911578 1.000 rs654778 chr17:56736473 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC cis rs2276314 1.000 rs4573997 chr18:33552568 C/T cg19628046 chr18:33552617 C18orf21 0.6 6.77 0.38 8.12e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg06636001 chr8:8085503 FLJ10661 0.51 6.35 0.36 9.5e-10 Mood instability; CESC cis rs9863 0.828 rs1187415 chr12:124491529 C/G cg17562584 chr12:124393655 DNAH10 -0.31 -5.41 -0.32 1.42e-7 White blood cell count; CESC cis rs7914558 1.000 rs10883824 chr10:104812897 A/G cg04362960 chr10:104952993 NT5C2 0.48 6.45 0.37 5.35e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs17764205 0.777 rs17696630 chr19:3261995 A/G cg12868887 chr11:70244470 CTTN -0.75 -6.0 -0.35 6.55e-9 Bipolar disorder and schizophrenia; CESC cis rs11792861 0.781 rs28361106 chr9:111762385 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.55 7.15 0.4 8.6e-12 Menarche (age at onset); CESC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg18133145 chr1:16060689 PLEKHM2 -0.41 -5.23 -0.31 3.41e-7 Systolic blood pressure; CESC cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.03e-7 Colorectal cancer; CESC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg23034840 chr1:205782522 SLC41A1 0.68 8.43 0.46 2.21e-15 Menarche (age at onset); CESC cis rs3204270 0.714 rs7503307 chr17:79674929 C/G cg18367735 chr17:79674897 NA 0.68 5.87 0.34 1.27e-8 Dental caries; CESC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg04369109 chr6:150039330 LATS1 -0.39 -5.34 -0.31 2.01e-7 Lung cancer; CESC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg04414720 chr1:150670196 GOLPH3L 0.63 9.03 0.48 3.76e-17 Melanoma; CESC cis rs2820292 0.967 rs2820290 chr1:201783682 A/G cg11586189 chr1:201857591 SHISA4 0.32 5.3 0.31 2.44e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs4478858 0.735 rs12134484 chr1:31823741 G/A cg00250761 chr1:31883323 NA -0.26 -5.06 -0.3 7.93e-7 Alcohol dependence; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27551169 chr15:85383124 ALPK3 0.51 6.56 0.37 2.78e-10 Fibrinogen levels; CESC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg26343298 chr8:95960752 TP53INP1 0.36 5.89 0.34 1.15e-8 Type 2 diabetes; CESC cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg22601191 chr20:60968625 CABLES2 0.53 6.61 0.38 2.16e-10 Colorectal cancer; CESC cis rs4950322 0.570 rs72692905 chr1:146773253 C/T cg22381352 chr1:146742008 CHD1L -0.46 -5.05 -0.3 8.32e-7 Protein quantitative trait loci; CESC cis rs6484504 0.532 rs11031332 chr11:31278962 T/C cg14844989 chr11:31128820 NA -0.41 -5.66 -0.33 3.89e-8 Red blood cell count; CESC cis rs3540 0.512 rs7176518 chr15:91079637 C/T cg10434728 chr15:90938212 IQGAP1 -0.39 -7.03 -0.4 1.74e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1153858 1.000 rs4775909 chr15:45643042 T/C cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15926737 chr12:57853737 GLI1 -0.47 -6.56 -0.37 2.79e-10 Gambling; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02656441 chr13:111367915 ING1 0.44 6.38 0.36 7.85e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6088590 1.000 rs6119512 chr20:33306904 T/C cg08999081 chr20:33150536 PIGU 0.6 9.27 0.49 6.6e-18 Coronary artery disease; CESC cis rs11792861 0.816 rs11790105 chr9:111731785 T/C cg05043794 chr9:111880884 C9orf5 -0.38 -6.25 -0.36 1.59e-9 Menarche (age at onset); CESC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg05368731 chr17:41323189 NBR1 0.58 8.23 0.45 8.76e-15 Menopause (age at onset); CESC cis rs644799 0.930 rs2186782 chr11:95649543 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.57 7.29 0.41 3.57e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6912958 0.781 rs2300906 chr6:88207155 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -7.33 -0.41 2.86e-12 Monocyte percentage of white cells; CESC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg18876405 chr7:65276391 NA 0.55 7.39 0.41 1.98e-12 Aortic root size; CESC cis rs738322 0.753 rs5756968 chr22:38595240 C/T cg17652424 chr22:38574118 PLA2G6 0.3 5.26 0.31 2.98e-7 Cutaneous nevi; CESC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg17724175 chr1:150552817 MCL1 0.42 6.36 0.36 8.99e-10 Melanoma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05740071 chr10:35299094 CUL2 -0.43 -6.1 -0.35 3.71e-9 Gut microbiota (bacterial taxa); CESC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg18876405 chr7:65276391 NA 0.69 9.64 0.51 4.96e-19 Calcium levels; CESC cis rs72780191 0.574 rs55836224 chr2:23895597 T/C cg08917208 chr2:24149416 ATAD2B 0.72 7.35 0.41 2.45e-12 White blood cell count; CESC cis rs72945132 0.882 rs7940090 chr11:70227824 C/G cg00319359 chr11:70116639 PPFIA1 0.73 7.1 0.4 1.11e-11 Coronary artery disease; CESC trans rs10463316 0.894 rs6880137 chr5:150755232 A/G cg24389359 chr12:111284228 CCDC63 -0.34 -6.09 -0.35 3.93e-9 Metabolite levels (Pyroglutamine); CESC cis rs9457247 0.765 rs9459849 chr6:167444160 G/T cg23791538 chr6:167370224 RNASET2 -0.55 -7.68 -0.43 3.01e-13 Crohn's disease; CESC cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.71 11.36 0.57 1.22e-24 Personality dimensions; CESC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg00684032 chr4:1343700 KIAA1530 0.42 5.93 0.34 9.41e-9 Obesity-related traits; CESC cis rs9443189 0.950 rs721264 chr6:76517896 G/A cg01950844 chr6:76311363 SENP6 0.53 5.78 0.33 2.09e-8 Prostate cancer; CESC cis rs7680126 0.596 rs12503603 chr4:10313757 T/G cg00071950 chr4:10020882 SLC2A9 -0.5 -5.25 -0.31 3.06e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs11039798 0.511 rs7948129 chr11:48167828 G/A cg15704280 chr7:45808275 SEPT13 -0.69 -6.85 -0.39 5.29e-11 Axial length; CESC cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.95 0.34 8.47e-9 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -9.22 -0.49 9.29e-18 Mean corpuscular volume; CESC cis rs1879734 0.689 rs55786134 chr1:54171981 T/C cg23596471 chr1:54105337 GLIS1 0.35 5.54 0.32 7.34e-8 Mitral valve prolapse; CESC cis rs712039 0.652 rs853197 chr17:35848716 T/C cg16670864 chr17:35848621 DUSP14 0.47 5.92 0.34 1.01e-8 Tuberculosis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25377665 chr17:36903811 PCGF2 -0.41 -6.21 -0.36 2.06e-9 Gambling; CESC cis rs3733585 0.699 rs6449174 chr4:9966422 C/T cg02734326 chr4:10020555 SLC2A9 -0.36 -5.06 -0.3 7.84e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs73110464 0.609 rs4919752 chr12:53359229 G/C cg16329197 chr12:53359506 NA -0.71 -10.45 -0.54 1.28e-21 Cancer (pleiotropy); CESC cis rs3768617 0.677 rs12739316 chr1:183052080 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.03 0.52 2.82e-20 Fuchs's corneal dystrophy; CESC trans rs9325144 0.723 rs10161183 chr12:39182087 T/C cg23762105 chr12:34175262 ALG10 0.45 6.14 0.35 3.01e-9 Morning vs. evening chronotype; CESC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg03452623 chr4:187889614 NA -0.88 -16.31 -0.71 7.08e-42 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00276377 chr13:77601664 FBXL3 -0.45 -6.04 -0.35 5.21e-9 Fibrinogen levels; CESC cis rs684232 0.649 rs838369 chr17:578180 T/C cg15660573 chr17:549704 VPS53 -0.63 -8.63 -0.47 5.65e-16 Prostate cancer; CESC cis rs9549367 0.789 rs9549695 chr13:113874814 A/G cg00898013 chr13:113819073 PROZ 0.48 6.78 0.38 7.85e-11 Platelet distribution width; CESC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg26335602 chr6:28129616 ZNF389 0.45 5.43 0.32 1.25e-7 Parkinson's disease; CESC cis rs71403859 0.667 rs12924650 chr16:71705908 C/T cg08717414 chr16:71523259 ZNF19 -0.73 -6.39 -0.37 7.59e-10 Post bronchodilator FEV1; CESC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg05368731 chr17:41323189 NBR1 0.79 11.23 0.57 3.39e-24 Menopause (age at onset); CESC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg14558114 chr2:88469736 THNSL2 0.58 5.53 0.32 7.83e-8 Plasma clusterin levels; CESC cis rs34779708 0.702 rs35969476 chr10:35544318 G/A cg04310649 chr10:35416472 CREM -0.47 -5.38 -0.31 1.67e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs2777491 1.000 rs66538814 chr15:41685917 G/T cg02330683 chr15:41787940 ITPKA 0.42 6.21 0.36 2.09e-9 Ulcerative colitis; CESC cis rs17376456 0.877 rs10060462 chr5:93455073 C/T cg21475434 chr5:93447410 FAM172A 0.9 7.81 0.43 1.31e-13 Diabetic retinopathy; CESC cis rs12478296 0.901 rs7603560 chr2:243043256 C/T cg06360820 chr2:242988706 NA -0.92 -8.99 -0.48 4.94e-17 Obesity-related traits; CESC cis rs9467773 0.595 rs12525810 chr6:26623511 T/TA cg12292205 chr6:26970375 C6orf41 -0.53 -5.47 -0.32 1.02e-7 Intelligence (multi-trait analysis); CESC cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg03060546 chr3:49711283 APEH 0.44 5.38 0.31 1.61e-7 Parkinson's disease; CESC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC cis rs16866061 1.000 rs3768886 chr2:225450161 G/C cg12698349 chr2:225449008 CUL3 0.72 10.62 0.55 3.57e-22 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs9894429 0.700 rs113915083 chr17:79552696 G/C cg18240062 chr17:79603768 NPLOC4 -0.86 -12.51 -0.61 1.61e-28 Eye color traits; CESC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg12463550 chr7:65579703 CRCP 0.47 6.08 0.35 4.21e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22234827 chr1:154947116 CKS1B;SHC1 0.66 7.19 0.4 6.76e-12 Gut microbiome composition (summer); CESC cis rs4835473 0.897 rs34380794 chr4:144656953 A/C cg25736465 chr4:144833511 NA -0.33 -5.25 -0.31 3.06e-7 Immature fraction of reticulocytes; CESC cis rs72945132 0.714 rs72947077 chr11:70197431 A/G cg00319359 chr11:70116639 PPFIA1 0.8 7.29 0.41 3.63e-12 Coronary artery disease; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg25978167 chr4:57301353 PAICS;PPAT -0.47 -6.26 -0.36 1.55e-9 Height; CESC cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg09824328 chr1:43425412 SLC2A1 -0.54 -5.61 -0.33 5.2e-8 Monocyte count; CESC trans rs7326068 0.610 rs9552275 chr13:21337389 G/A cg00192819 chr18:76486611 NA 0.43 6.13 0.35 3.11e-9 Schizophrenia, bipolar disorder and depression (combined); CESC cis rs971768 0.892 rs62623403 chr22:17595175 C/T cg06707910 chr22:17640812 CECR5;CECR4 -0.65 -5.96 -0.34 8.13e-9 Heschl's gyrus morphology; CESC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg19468946 chr17:37922297 IKZF3 -0.41 -5.3 -0.31 2.47e-7 Glomerular filtration rate (creatinine); CESC trans rs57221529 0.766 rs4081847 chr5:574072 C/T cg25482853 chr8:67687455 SGK3 1.05 10.38 0.54 2.11e-21 Lung disease severity in cystic fibrosis; CESC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg23978390 chr7:1156363 C7orf50 0.65 9.3 0.5 5.61e-18 Longevity;Endometriosis; CESC cis rs11640734 0.619 rs2293586 chr16:89962394 A/G cg04013166 chr16:89971882 TCF25 0.7 8.34 0.46 4.03e-15 Interleukin-17 levels; CESC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 7.96 0.44 4.98e-14 Alzheimer's disease; CESC cis rs7762018 0.607 rs3800544 chr6:170058374 C/T cg19338460 chr6:170058176 WDR27 -0.78 -6.9 -0.39 3.74e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9399137 0.507 rs6918512 chr6:135284839 T/G cg22676075 chr6:135203613 NA 0.53 7.0 0.39 2.14e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs9916302 0.904 rs9905432 chr17:37555918 C/A cg20243544 chr17:37824526 PNMT -0.51 -6.5 -0.37 4.03e-10 Glomerular filtration rate (creatinine); CESC cis rs826838 1.000 rs11183469 chr12:38752311 G/A cg13010199 chr12:38710504 ALG10B 0.62 8.74 0.47 2.7e-16 Heart rate; CESC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg09509183 chr1:209979624 IRF6 0.56 5.8 0.34 1.9e-8 Cleft lip with or without cleft palate; CESC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg24399712 chr22:39784796 NA -0.82 -10.79 -0.55 9.78e-23 Intelligence (multi-trait analysis); CESC cis rs854765 0.547 rs2955372 chr17:17970229 T/C cg16928487 chr17:17741425 SREBF1 0.55 9.17 0.49 1.39e-17 Total body bone mineral density; CESC cis rs10911232 0.507 rs6668980 chr1:183018857 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 13.5 0.64 6.03e-32 Hypertriglyceridemia; CESC cis rs2180341 0.640 rs11154395 chr6:127629138 T/C cg27446573 chr6:127587934 RNF146 0.64 8.54 0.46 1.07e-15 Breast cancer; CESC cis rs863345 0.967 rs5009954 chr1:158530417 A/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.51 -0.37 3.8e-10 Pneumococcal bacteremia; CESC cis rs977987 0.836 rs17685540 chr16:75323840 T/C cg03315344 chr16:75512273 CHST6 0.37 5.35 0.31 1.94e-7 Dupuytren's disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18433293 chr15:41576837 LOC729082 -0.46 -6.26 -0.36 1.52e-9 Asthma; CESC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg17689763 chr4:710664 PCGF3 -0.48 -6.39 -0.37 7.35e-10 White blood cell count; CESC cis rs2249625 0.545 rs9791273 chr6:72891016 G/T cg18830697 chr6:72922368 RIMS1 0.4 5.75 0.33 2.45e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg17221315 chr6:27791827 HIST1H4J 0.41 5.35 0.31 1.9e-7 Parkinson's disease; CESC cis rs1008375 0.966 rs4698642 chr4:17679174 A/T cg16339924 chr4:17578868 LAP3 0.49 6.24 0.36 1.72e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02903691 chr16:18573200 NOMO2 -0.49 -6.34 -0.36 9.68e-10 Fibrinogen levels; CESC cis rs9583531 0.689 rs9588247 chr13:111375571 G/T cg24331049 chr13:111365604 ING1 -0.72 -10.28 -0.53 4.33e-21 Coronary artery disease; CESC cis rs921968 0.643 rs678218 chr2:219379709 C/A cg02176678 chr2:219576539 TTLL4 0.39 6.81 0.39 6.35e-11 Mean corpuscular hemoglobin concentration; CESC cis rs863345 0.967 rs1592255 chr1:158470556 G/C cg12129480 chr1:158549410 OR10X1 -0.31 -6.19 -0.36 2.34e-9 Pneumococcal bacteremia; CESC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg11890956 chr21:40555474 PSMG1 1.17 22.39 0.81 4.79e-63 Cognitive function; CESC cis rs2204008 0.774 rs7304438 chr12:38361146 T/G cg26384229 chr12:38710491 ALG10B 0.73 10.95 0.56 2.81e-23 Bladder cancer; CESC cis rs2996428 0.667 rs61768932 chr1:3765671 G/C cg13057898 chr1:3703894 LRRC47 0.44 5.93 0.34 9.24e-9 Red cell distribution width; CESC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg24642844 chr7:1081250 C7orf50 -0.78 -9.49 -0.5 1.38e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7927771 0.524 rs7118747 chr11:47889545 C/T cg18512352 chr11:47633146 NA -0.36 -5.57 -0.32 6.22e-8 Subjective well-being; CESC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg13866156 chr1:1669148 SLC35E2 -0.51 -6.6 -0.38 2.17e-10 Body mass index; CESC cis rs7264396 0.635 rs6058358 chr20:34492560 A/T cg23207816 chr20:34252616 CPNE1;RBM12 0.59 7.2 0.4 6.2e-12 Total cholesterol levels; CESC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.16e-7 Aortic root size; CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg18876405 chr7:65276391 NA 0.47 6.25 0.36 1.6e-9 Calcium levels; CESC cis rs1670533 1.000 rs604597 chr4:1094151 G/A cg27284194 chr4:1044797 NA -0.47 -6.01 -0.35 6.08e-9 Recombination rate (females); CESC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.88 15.42 0.69 9.82e-39 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14835113 chr13:111303423 CARS2 -0.68 -7.66 -0.43 3.49e-13 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg22535103 chr8:58192502 C8orf71 -1.07 -13.22 -0.63 5.72e-31 Developmental language disorder (linguistic errors); CESC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg27297192 chr10:134578999 INPP5A 0.39 5.19 0.3 4.29e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.84 0.34 1.51e-8 Tonsillectomy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27649522 chr12:12877729 APOLD1 0.48 6.22 0.36 1.88e-9 Gut microbiota (bacterial taxa); CESC cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg13902645 chr11:5959945 NA -0.66 -7.99 -0.44 4.26e-14 DNA methylation (variation); CESC cis rs965469 0.779 rs6051683 chr20:3237822 G/C cg25506879 chr20:3388711 C20orf194 -0.51 -5.57 -0.32 6.1e-8 IFN-related cytopenia; CESC cis rs2637266 0.714 rs1965156 chr10:78450559 G/A cg18941641 chr10:78392320 NA 0.43 7.8 0.43 1.43e-13 Pulmonary function; CESC cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs854765 0.562 rs2955381 chr17:17945500 G/C cg04398451 chr17:18023971 MYO15A 0.73 10.55 0.54 5.95e-22 Total body bone mineral density; CESC cis rs3026101 0.578 rs3026142 chr17:5315089 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.83 0.34 1.6e-8 Body mass index; CESC cis rs1728785 1.000 rs7202306 chr16:68587684 G/A cg02972257 chr16:68554789 NA -0.58 -6.56 -0.37 2.75e-10 Ulcerative colitis; CESC cis rs3540 0.574 rs8035980 chr15:90974390 C/G cg10434728 chr15:90938212 IQGAP1 0.39 7.12 0.4 1.02e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs6546550 0.901 rs34586537 chr2:70163316 G/T cg02498382 chr2:70120550 SNRNP27 0.42 7.31 0.41 3.24e-12 Prevalent atrial fibrillation; CESC cis rs116095464 0.558 rs6555056 chr5:226222 T/C cg20965017 chr5:231967 SDHA -0.44 -5.04 -0.3 8.77e-7 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09901100 chr7:134867116 NA 0.51 6.8 0.39 6.81e-11 Fibrinogen levels; CESC cis rs672059 0.513 rs627064 chr1:183165716 C/T cg01949993 chr1:183155116 LAMC2 -0.29 -5.26 -0.31 2.91e-7 Hypertriglyceridemia; CESC cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg23711669 chr6:146136114 FBXO30 0.94 14.19 0.66 2.3e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs7680126 0.633 rs4698040 chr4:10352550 C/T cg00071950 chr4:10020882 SLC2A9 -0.53 -5.86 -0.34 1.37e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1568889 0.877 rs17310076 chr11:28147590 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.69 6.89 0.39 4e-11 Bipolar disorder; CESC cis rs11252926 0.598 rs4881256 chr10:453831 T/A cg18196295 chr10:418757 DIP2C 0.55 7.61 0.42 4.82e-13 Psychosis in Alzheimer's disease; CESC cis rs3857067 1.000 rs2219755 chr4:95015684 A/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs11711311 0.955 rs34048496 chr3:113414121 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.66 8.82 0.48 1.54e-16 IgG glycosylation; CESC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg12034118 chr1:209979487 IRF6 0.43 5.27 0.31 2.85e-7 Cleft lip with or without cleft palate; CESC cis rs6582630 0.502 rs11520279 chr12:38360871 A/G cg26384229 chr12:38710491 ALG10B 0.69 10.42 0.54 1.6e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs854765 0.927 rs4925138 chr17:17992793 T/G cg04398451 chr17:18023971 MYO15A 0.68 9.62 0.51 5.65e-19 Total body bone mineral density; CESC cis rs11931598 0.511 rs4689576 chr4:7025523 T/C cg26116260 chr4:7069785 GRPEL1 0.4 5.51 0.32 8.29e-8 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14195377 chr11:60928647 VPS37C -0.46 -6.27 -0.36 1.43e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg01988459 chr11:68622903 NA -0.42 -5.76 -0.33 2.29e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs34779708 0.931 rs10437420 chr10:35335044 A/C cg03585969 chr10:35415529 CREM -0.77 -10.11 -0.53 1.57e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs10782582 0.593 rs79552201 chr1:76215497 A/T cg10523679 chr1:76189770 ACADM -0.48 -5.59 -0.32 5.59e-8 Daytime sleep phenotypes; CESC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg14926445 chr8:58193284 C8orf71 -0.52 -5.26 -0.31 2.91e-7 Developmental language disorder (linguistic errors); CESC cis rs3105593 0.932 rs2414072 chr15:50850562 T/A cg08437265 chr15:50716283 USP8 0.41 5.29 0.31 2.54e-7 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02823137 chr17:79235689 SLC38A10 -0.61 -7.41 -0.41 1.66e-12 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg17366294 chr4:99064904 C4orf37 0.58 8.26 0.45 7.11e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4589502 0.502 rs2169460 chr15:67197240 A/G cg12317470 chr15:67143691 NA -0.8 -11.28 -0.57 2.39e-24 Lung cancer (smoking interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13784889 chr4:89513377 HERC3 0.5 6.42 0.37 6.37e-10 Gut microbiota (bacterial taxa); CESC cis rs1030877 0.515 rs920217 chr2:105904662 C/T cg02079111 chr2:105885981 TGFBRAP1 -0.48 -6.3 -0.36 1.26e-9 Obesity-related traits; CESC cis rs4704187 0.687 rs6862740 chr5:74405749 A/T cg03227963 chr5:74354835 NA 0.32 5.94 0.34 8.7e-9 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07011025 chr1:231114438 ARV1;TTC13 0.54 6.28 0.36 1.37e-9 Gut microbiome composition (summer); CESC cis rs2708240 1.000 rs2247143 chr7:147581107 C/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.55 -0.32 7.07e-8 QT interval (drug interaction); CESC cis rs1879734 0.731 rs10888803 chr1:54160235 C/T cg23596471 chr1:54105337 GLIS1 0.35 5.7 0.33 3.12e-8 Mitral valve prolapse; CESC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -7.2 -0.4 6.32e-12 Bipolar disorder and schizophrenia; CESC cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg11752832 chr7:134001865 SLC35B4 0.52 6.77 0.38 8.19e-11 Mean platelet volume; CESC cis rs11098499 0.863 rs1480936 chr4:120462861 C/T cg09307838 chr4:120376055 NA 0.9 12.35 0.6 5.71e-28 Corneal astigmatism; CESC cis rs4481887 0.962 rs4369256 chr1:248492274 G/A cg00666640 chr1:248458726 OR2T12 0.41 6.74 0.38 9.64e-11 Common traits (Other); CESC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg15664640 chr17:80829946 TBCD 0.38 5.41 0.32 1.42e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12813709 chr11:576467 PHRF1;LOC143666 0.53 6.08 0.35 4.08e-9 Gut microbiome composition (summer); CESC cis rs1256061 0.630 rs1256030 chr14:64747170 A/G cg23250157 chr14:64679961 SYNE2 0.48 6.79 0.38 7.37e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs9354352 0.967 rs6455062 chr6:66694131 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.69 10.02 0.52 3.05e-20 Initial pursuit acceleration in psychotic disorders; CESC cis rs73206853 0.764 rs59527539 chr12:110968119 A/G cg04375036 chr12:111181819 PPP1CC -0.54 -5.04 -0.3 8.83e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs1814175 0.645 rs7115592 chr11:50013243 A/G cg03929089 chr4:120376271 NA -0.91 -14.65 -0.67 5.08e-36 Height; CESC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 8.51 0.46 1.27e-15 Platelet count; CESC cis rs561341 0.941 rs2428341 chr17:30317295 C/T cg12193833 chr17:30244370 NA -0.52 -5.99 -0.35 6.91e-9 Hip circumference adjusted for BMI; CESC cis rs7937682 0.562 rs7938620 chr11:111366844 G/A cg09085632 chr11:111637200 PPP2R1B 0.58 7.27 0.41 3.98e-12 Primary sclerosing cholangitis; CESC cis rs9916302 0.851 rs12936996 chr17:37665554 A/G cg20243544 chr17:37824526 PNMT -0.5 -6.41 -0.37 6.81e-10 Glomerular filtration rate (creatinine); CESC cis rs4523957 0.928 rs11869805 chr17:2176532 A/G cg16513277 chr17:2031491 SMG6 -0.59 -8.04 -0.44 3.02e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4561483 0.583 rs11645213 chr16:11942924 C/A cg08843971 chr16:11963173 GSPT1 0.47 6.49 0.37 4.21e-10 Testicular germ cell tumor; CESC cis rs6964587 0.967 rs2299235 chr7:91627500 C/T cg17063962 chr7:91808500 NA 0.57 7.86 0.43 9.99e-14 Breast cancer; CESC cis rs644799 1.000 rs586238 chr11:95560371 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.31 0.66 8.38e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs17376456 0.825 rs13182631 chr5:93115701 A/G cg21475434 chr5:93447410 FAM172A 0.8 7.22 0.41 5.48e-12 Diabetic retinopathy; CESC cis rs208520 0.874 rs208469 chr6:66915891 T/C cg07460842 chr6:66804631 NA -0.87 -10.57 -0.54 5.25e-22 Exhaled nitric oxide output; CESC cis rs3916 1.000 rs34708625 chr12:121180019 T/C cg21892295 chr12:121157589 UNC119B -0.35 -5.07 -0.3 7.41e-7 Urinary metabolites (H-NMR features); CESC cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg13877915 chr19:58951672 ZNF132 0.4 5.88 0.34 1.24e-8 Uric acid clearance; CESC cis rs921968 0.565 rs7562426 chr2:219605118 G/A cg02176678 chr2:219576539 TTLL4 -0.47 -8.28 -0.45 6.04e-15 Mean corpuscular hemoglobin concentration; CESC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg04414720 chr1:150670196 GOLPH3L 0.5 6.49 0.37 4.21e-10 Melanoma; CESC cis rs2637266 0.935 rs1978927 chr10:78399786 A/T cg18941641 chr10:78392320 NA 0.44 8.31 0.45 5.07e-15 Pulmonary function; CESC cis rs9814567 1.000 rs4498009 chr3:134198008 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.11 -0.35 3.53e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs1945213 0.694 rs1384099 chr11:55866040 A/C cg15704280 chr7:45808275 SEPT13 0.69 6.65 0.38 1.66e-10 Acute lymphoblastic leukemia (childhood); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05255807 chr6:88411528 NCRNA00120;AKIRIN2 -0.48 -6.17 -0.35 2.54e-9 Ulcerative colitis; CESC cis rs7927592 0.626 rs11228279 chr11:68309680 C/T cg16797656 chr11:68205561 LRP5 -0.48 -7.41 -0.41 1.7e-12 Total body bone mineral density; CESC cis rs9303401 0.615 rs35288118 chr17:56600748 A/C cg10487724 chr17:56770010 TEX14;RAD51C 1.0 11.19 0.57 4.8e-24 Cognitive test performance; CESC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg05863683 chr7:1912471 MAD1L1 0.38 5.49 0.32 9.37e-8 Bipolar disorder and schizophrenia; CESC cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg00934597 chr7:893267 UNC84A -0.49 -6.55 -0.37 2.95e-10 Perceived unattractiveness to mosquitoes; CESC cis rs55883249 1.000 rs62119428 chr2:9743332 T/C cg23886495 chr2:9695866 ADAM17 0.61 5.52 0.32 8.11e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs6696846 0.765 rs11576867 chr1:205064676 C/T cg00857998 chr1:205179979 DSTYK 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs727505 1.000 rs67585224 chr7:124537476 A/C cg23710748 chr7:124431027 NA -0.48 -7.5 -0.42 9.36e-13 Lewy body disease; CESC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs4304924 0.500 rs12585725 chr13:79220899 C/A cg01819759 chr13:79234251 RNF219 0.41 5.3 0.31 2.4e-7 Large artery stroke; CESC trans rs2764766 0.755 rs245310 chr5:127166633 C/T cg15764593 chr10:829463 NA 0.4 6.27 0.36 1.42e-9 Schizophrenia; CESC cis rs2204008 0.837 rs4432085 chr12:38181146 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs11958404 0.929 rs79656592 chr5:157430291 G/A cg05962755 chr5:157440814 NA 0.63 6.63 0.38 1.87e-10 IgG glycosylation; CESC cis rs796364 0.806 rs74266489 chr2:201005732 G/A cg23649088 chr2:200775458 C2orf69 -0.55 -5.04 -0.3 8.69e-7 Schizophrenia; CESC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg11764359 chr7:65958608 NA 0.96 15.25 0.68 3.95e-38 Aortic root size; CESC cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7561273 0.586 rs11900665 chr2:24298198 T/C cg20701182 chr2:24300061 SF3B14 0.45 6.11 0.35 3.57e-9 Quantitative traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22512163 chr5:73205678 RGNEF -0.58 -6.71 -0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs2070997 0.667 rs7869508 chr9:133716802 T/C cg11464064 chr9:133710261 ABL1 0.68 7.65 0.43 3.64e-13 Response to amphetamines; CESC cis rs6912958 0.781 rs2207146 chr6:88180641 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.4 -5.19 -0.3 4.09e-7 Monocyte percentage of white cells; CESC cis rs3617 0.652 rs60332615 chr3:52867595 C/A cg07507251 chr3:52567010 NT5DC2 -0.32 -5.4 -0.31 1.5e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs9660992 0.762 rs1172129 chr1:205244972 T/A cg21643547 chr1:205240462 TMCC2 -0.46 -6.73 -0.38 1.05e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.66 9.32 0.5 4.58e-18 Menarche (age at onset); CESC cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.65 0.33 4.11e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.17 0.57 5.32e-24 Alzheimer's disease; CESC cis rs2276314 0.857 rs28375959 chr18:33601534 T/G cg05985134 chr18:33552581 C18orf21 0.61 7.12 0.4 1.01e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs898097 0.841 rs8074284 chr17:80909967 G/A cg05255149 chr17:80675120 FN3KRP 0.45 5.14 0.3 5.47e-7 Breast cancer; CESC cis rs7116495 0.609 rs79889241 chr11:71815585 T/C cg18441811 chr11:71824068 C11orf51 0.82 5.16 0.3 4.89e-7 Severe influenza A (H1N1) infection; CESC cis rs17666538 0.585 rs4333567 chr8:636611 C/T cg02524346 chr8:600233 NA 0.88 5.5 0.32 8.8e-8 IgG glycosylation; CESC cis rs736408 0.677 rs678 chr3:52820981 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.45 5.95 0.34 8.48e-9 Bipolar disorder; CESC cis rs9596863 1.000 rs35429587 chr13:54406523 T/A ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg11843238 chr5:131593191 PDLIM4 -0.35 -5.11 -0.3 6.14e-7 Acylcarnitine levels; CESC cis rs763014 0.931 rs56048717 chr16:634867 A/G cg09263875 chr16:632152 PIGQ 0.67 11.45 0.58 6.39e-25 Height; CESC cis rs9487051 0.676 rs1608042 chr6:109595631 G/A cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC cis rs3825932 0.701 rs1036937 chr15:79237180 C/A cg25744700 chr15:79237217 CTSH 0.49 6.29 0.36 1.3e-9 Type 1 diabetes; CESC cis rs933688 0.938 rs1477348 chr5:90707823 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 14.23 0.66 1.63e-34 Smoking behavior; CESC trans rs2965280 0.793 rs8106201 chr19:34836889 C/T cg05799317 chr6:165723796 C6orf118 0.81 6.0 0.35 6.45e-9 Colorectal cancer; CESC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg14664628 chr15:75095509 CSK -0.53 -6.69 -0.38 1.29e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00111436 chr12:121837826 RNF34 0.66 8.06 0.44 2.59e-14 Gut microbiome composition (summer); CESC cis rs1577917 0.958 rs12193904 chr6:86452703 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.53 -6.89 -0.39 4.05e-11 Response to antipsychotic treatment; CESC cis rs9815354 0.812 rs73079324 chr3:41864564 T/C cg03022575 chr3:42003672 ULK4 0.46 5.29 0.31 2.57e-7 Pulse pressure;Diastolic blood pressure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04324509 chr3:101295624 PCNP -0.53 -7.52 -0.42 8.35e-13 Gut microbiota (bacterial taxa); CESC cis rs870825 0.616 rs10022818 chr4:185619282 A/G cg04058563 chr4:185651563 MLF1IP 0.63 7.0 0.4 2.06e-11 Blood protein levels; CESC cis rs4663969 0.873 rs759174 chr2:234668245 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.5 -6.47 -0.37 4.82e-10 Total bilirubin levels in HIV-1 infection; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16528022 chr14:65438707 RAB15 -0.45 -6.06 -0.35 4.6e-9 Gut microbiota (bacterial taxa); CESC cis rs4594175 0.926 rs4318127 chr14:51624897 G/C cg23942311 chr14:51606299 NA 0.39 5.93 0.34 9.29e-9 Cancer; CESC cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg17366294 chr4:99064904 C4orf37 0.59 8.52 0.46 1.24e-15 Colonoscopy-negative controls vs population controls; CESC cis rs3820928 0.845 rs4234065 chr2:227882006 C/T cg11843606 chr2:227700838 RHBDD1 -0.46 -6.09 -0.35 3.87e-9 Pulmonary function; CESC cis rs3020736 0.500 rs6002603 chr22:42492362 C/G cg15557168 chr22:42548783 NA 0.45 6.18 0.35 2.46e-9 Autism spectrum disorder or schizophrenia; CESC cis rs919433 0.662 rs2043018 chr2:198236958 G/A cg10820045 chr2:198174542 NA 0.41 6.03 0.35 5.34e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs561341 0.783 rs512698 chr17:30292507 G/T cg27661571 chr11:113659931 NA -0.83 -7.66 -0.43 3.57e-13 Hip circumference adjusted for BMI; CESC cis rs7312774 0.881 rs7309260 chr12:107313254 T/A cg16260113 chr12:107380972 MTERFD3 0.64 6.06 0.35 4.62e-9 Severe influenza A (H1N1) infection; CESC cis rs4237845 0.537 rs12312955 chr12:58265223 A/G cg02175503 chr12:58329896 NA 0.49 5.85 0.34 1.43e-8 Intelligence (multi-trait analysis); CESC cis rs78707713 0.836 rs77602872 chr10:71211734 G/A cg12610070 chr10:71211762 TSPAN15 -0.4 -6.79 -0.39 7.15e-11 Venous thromboembolism; CESC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg08470875 chr2:26401718 FAM59B -0.47 -5.24 -0.31 3.31e-7 Gut microbiome composition (summer); CESC cis rs7647973 0.925 rs4955439 chr3:49245645 G/T cg13072238 chr3:49761600 GMPPB 0.39 5.06 0.3 7.87e-7 Menarche (age at onset); CESC cis rs10924309 0.889 rs10802246 chr1:245858493 T/G cg00036263 chr1:245852353 KIF26B -0.42 -5.29 -0.31 2.54e-7 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21168982 chr1:28559030 DNAJC8 -0.44 -6.01 -0.35 6.07e-9 Asthma; CESC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg04414720 chr1:150670196 GOLPH3L 0.63 8.98 0.48 5.09e-17 Tonsillectomy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07611812 chr8:53627203 RB1CC1 -0.45 -6.16 -0.35 2.71e-9 Gambling; CESC trans rs4824093 0.610 rs12106611 chr22:50242686 G/A cg09872104 chr7:134855509 C7orf49 -0.95 -6.67 -0.38 1.52e-10 Amyotrophic lateral sclerosis (sporadic); CESC cis rs3820068 0.581 rs16851851 chr1:15929628 C/G cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs62064224 0.714 rs11653974 chr17:30635002 T/C cg18200150 chr17:30822561 MYO1D 0.4 5.42 0.32 1.31e-7 Schizophrenia; CESC cis rs5758659 0.652 rs133322 chr22:42405659 A/G cg04733989 chr22:42467013 NAGA 0.47 6.36 0.36 8.68e-10 Cognitive function; CESC cis rs2249625 0.844 rs1830339 chr6:72877600 G/A cg18830697 chr6:72922368 RIMS1 -0.39 -5.53 -0.32 7.7e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs1559088 0.739 rs9304845 chr19:33592794 A/G cg27124370 chr19:33622961 WDR88 0.45 5.97 0.34 7.78e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg18016565 chr1:150552671 MCL1 0.34 5.33 0.31 2.07e-7 Tonsillectomy; CESC cis rs11153306 0.818 rs7764009 chr6:111944596 G/T cg22127309 chr6:111907043 TRAF3IP2 0.4 6.09 0.35 3.87e-9 Tonsillectomy; CESC cis rs73206853 0.563 rs16940950 chr12:111136459 A/G cg12870014 chr12:110450643 ANKRD13A 0.72 6.19 0.36 2.27e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs965469 1.000 rs6051806 chr20:3350319 C/T cg25506879 chr20:3388711 C20orf194 -0.58 -6.17 -0.35 2.6e-9 IFN-related cytopenia; CESC cis rs2115536 1.000 rs2903105 chr15:80189523 C/G cg00225070 chr15:80189496 MTHFS 0.61 8.58 0.47 7.87e-16 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs9910055 0.529 rs400460 chr17:42182770 A/G cg13607699 chr17:42295918 UBTF -0.43 -5.58 -0.32 5.8e-8 Total body bone mineral density; CESC cis rs7582720 1.000 rs72934751 chr2:203747522 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs34172651 0.687 rs8044992 chr16:24811207 T/C cg06028605 chr16:24865363 SLC5A11 0.45 6.94 0.39 3.01e-11 Intelligence (multi-trait analysis); CESC cis rs10851478 0.872 rs34246470 chr15:49796697 C/T cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs9457247 0.765 rs9457251 chr6:167426707 T/C cg23791538 chr6:167370224 RNASET2 -0.53 -7.32 -0.41 3.03e-12 Crohn's disease; CESC cis rs1008375 1.000 rs10805357 chr4:17652352 G/A cg16339924 chr4:17578868 LAP3 0.56 7.02 0.4 1.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504073 0.647 rs1511359 chr8:50006448 T/A cg00325661 chr8:49890786 NA 0.56 8.34 0.46 4.04e-15 Blood metabolite ratios; CESC cis rs1784581 0.588 rs9346893 chr6:162417511 C/G cg17173639 chr6:162384350 PARK2 0.57 8.72 0.47 3.12e-16 Itch intensity from mosquito bite; CESC cis rs116095464 0.558 rs10057492 chr5:239503 T/C cg10591111 chr5:226296 SDHA -0.52 -6.32 -0.36 1.1e-9 Breast cancer; CESC cis rs96067 0.711 rs272811 chr1:36634414 G/A cg24686825 chr1:36642396 MAP7D1 -0.64 -8.17 -0.45 1.26e-14 Corneal structure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09579959 chr1:228327934 GUK1 0.51 6.04 0.35 5.28e-9 Gut microbiome composition (summer); CESC cis rs2072732 0.861 rs72856440 chr1:2956582 A/G cg15211996 chr1:2936768 ACTRT2 0.33 5.91 0.34 1.07e-8 Plateletcrit; CESC cis rs4704187 0.687 rs4235683 chr5:74415088 T/C cg03227963 chr5:74354835 NA 0.31 5.7 0.33 3.22e-8 Response to amphetamines; CESC cis rs7666738 0.606 rs7663216 chr4:99088385 A/C cg24818145 chr4:99064322 C4orf37 0.4 5.24 0.31 3.27e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs4642101 0.618 rs9877079 chr3:12821287 A/G cg05775895 chr3:12838266 CAND2 0.41 6.33 0.36 1.04e-9 QRS complex (12-leadsum); CESC cis rs17253792 0.822 rs11546 chr14:56146357 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.78 5.66 0.33 4e-8 Putamen volume; CESC cis rs4423214 0.840 rs1792226 chr11:71176574 C/T cg05163923 chr11:71159392 DHCR7 -0.65 -7.55 -0.42 6.91e-13 Vitamin D levels; CESC cis rs1983170 0.736 rs13447479 chr1:91970464 T/G cg02896835 chr1:92012615 NA 0.56 5.95 0.34 8.39e-9 Eosinophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25620125 chr11:61106775 DAK 0.47 6.16 0.35 2.66e-9 Fibrinogen levels; CESC cis rs7580658 0.724 rs7568261 chr2:128117324 C/T cg10021288 chr2:128175891 PROC -0.37 -6.02 -0.35 5.86e-9 Protein C levels; CESC cis rs4689388 0.679 rs1046316 chr4:6304087 A/G cg00701064 chr4:6280414 WFS1 0.6 8.87 0.48 1.11e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs854765 0.583 rs8070128 chr17:17804725 C/T cg09796270 chr17:17721594 SREBF1 -0.46 -6.39 -0.37 7.6e-10 Total body bone mineral density; CESC trans rs453301 0.571 rs330054 chr8:9088291 G/A cg15556689 chr8:8085844 FLJ10661 -0.52 -6.57 -0.37 2.61e-10 Joint mobility (Beighton score); CESC trans rs1728785 0.901 rs1103286 chr16:68578625 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs12142240 0.698 rs12385697 chr1:46818898 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs1153858 1.000 rs2056493 chr15:45648272 A/G cg14582100 chr15:45693742 SPATA5L1 0.4 6.03 0.35 5.43e-9 Homoarginine levels; CESC cis rs35110281 0.774 rs1378080 chr21:45011315 T/A cg01579765 chr21:45077557 HSF2BP -0.56 -9.34 -0.5 4.09e-18 Mean corpuscular volume; CESC cis rs7584330 0.738 rs13398506 chr2:238374824 A/G cg14458575 chr2:238380390 NA 0.62 8.3 0.45 5.37e-15 Prostate cancer; CESC cis rs2070677 0.935 rs12261048 chr10:135407923 A/G cg20169779 chr10:135381914 SYCE1 -0.77 -10.24 -0.53 5.89e-21 Gout; CESC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg04772025 chr11:68637568 NA 0.55 6.49 0.37 4.17e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10208940 0.920 rs7571506 chr2:68836317 C/A cg12452813 chr2:68675892 NA 0.51 5.12 0.3 5.95e-7 Urate levels in lean individuals; CESC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg00166722 chr3:10149974 C3orf24 0.48 5.95 0.34 8.39e-9 Alzheimer's disease; CESC cis rs910316 0.687 rs175059 chr14:75490667 T/C cg15467112 chr14:75489610 MLH3 -0.34 -5.26 -0.31 3.02e-7 Height; CESC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg18876405 chr7:65276391 NA -0.53 -6.94 -0.39 2.97e-11 Calcium levels; CESC cis rs4906332 1.000 rs4906327 chr14:103929039 C/T cg09975044 chr14:104007538 NA 0.47 6.45 0.37 5.25e-10 Coronary artery disease; CESC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg25985355 chr7:65971099 NA 0.31 5.08 0.3 7e-7 Aortic root size; CESC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg06873352 chr17:61820015 STRADA 0.71 12.61 0.61 6.99e-29 Prudent dietary pattern; CESC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg24060327 chr5:131705240 SLC22A5 -0.4 -5.04 -0.3 8.52e-7 Breast cancer; CESC cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05380570 chr1:17866686 ARHGEF10L -0.43 -6.2 -0.36 2.21e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11166927 0.524 rs2035087 chr8:140831320 A/G cg16909799 chr8:140841666 TRAPPC9 -0.62 -9.71 -0.51 2.79e-19 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs7264396 0.790 rs2425115 chr20:34322418 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.75 -0.59 5.91e-26 Total cholesterol levels; CESC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg16049864 chr8:95962084 TP53INP1 -0.71 -13.02 -0.62 2.84e-30 Type 2 diabetes; CESC cis rs9790314 0.747 rs4616689 chr3:160856269 A/G cg04691961 chr3:161091175 C3orf57 -0.4 -5.39 -0.31 1.52e-7 Morning vs. evening chronotype; CESC cis rs1568889 0.838 rs1525717 chr11:28081205 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.5 0.64 5.83e-32 Bipolar disorder; CESC cis rs2295499 0.643 rs59609182 chr4:2721530 C/T cg08330972 chr4:2403930 ZFYVE28 -0.31 -5.18 -0.3 4.35e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs7584330 0.554 rs77956735 chr2:238399130 C/T cg14458575 chr2:238380390 NA 0.66 5.47 0.32 1.06e-7 Prostate cancer; CESC cis rs10751667 0.666 rs11246357 chr11:963980 A/C cg06064525 chr11:970664 AP2A2 -0.47 -9.24 -0.49 8.25e-18 Alzheimer's disease (late onset); CESC cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg20307385 chr11:47447363 PSMC3 -0.53 -6.32 -0.36 1.07e-9 Subjective well-being; CESC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg26335602 chr6:28129616 ZNF389 -0.55 -7.15 -0.4 8.52e-12 Depression; CESC cis rs5753618 0.504 rs8142121 chr22:31882785 G/A cg00478049 chr22:31556069 RNF185 -0.46 -5.28 -0.31 2.66e-7 Colorectal cancer; CESC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg17328964 chr8:145687451 CYHR1 -0.57 -7.93 -0.44 6.05e-14 Age at first birth; CESC cis rs735539 1.000 rs9506537 chr13:21280410 T/C cg04906043 chr13:21280425 IL17D 0.39 6.0 0.35 6.3e-9 Dental caries; CESC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg04553112 chr3:125709451 NA -0.47 -5.34 -0.31 1.97e-7 Blood pressure (smoking interaction); CESC cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12478296 0.786 rs28802397 chr2:243049730 G/A cg06360820 chr2:242988706 NA -0.66 -7.55 -0.42 7.07e-13 Obesity-related traits; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04318602 chr14:53162623 ERO1L 0.47 6.09 0.35 3.98e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg21782813 chr7:2030301 MAD1L1 0.45 6.6 0.38 2.29e-10 Bipolar disorder and schizophrenia; CESC cis rs1005277 0.505 rs200935 chr10:38132810 T/A cg25427524 chr10:38739819 LOC399744 -0.68 -10.04 -0.52 2.67e-20 Extrinsic epigenetic age acceleration; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17703834 chr19:13228980 TRMT1;NACC1 0.4 6.01 0.35 6.11e-9 Systemic lupus erythematosus; CESC cis rs9487051 0.621 rs9374076 chr6:109597826 G/T cg01475377 chr6:109611718 NA -0.39 -5.04 -0.3 8.81e-7 Reticulocyte fraction of red cells; CESC cis rs10905065 0.965 rs10752110 chr10:5837038 T/C cg11519256 chr10:5708881 ASB13 0.44 6.11 0.35 3.51e-9 Menopause (age at onset); CESC cis rs8070624 0.543 rs8068175 chr17:17874486 C/T cg09796270 chr17:17721594 SREBF1 0.43 5.68 0.33 3.48e-8 Total body bone mineral density; CESC cis rs1707322 0.752 rs28507722 chr1:46206540 A/G cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6973256 0.637 rs12539993 chr7:133418799 C/T cg10665199 chr7:133106180 EXOC4 0.44 6.18 0.35 2.47e-9 Intelligence (multi-trait analysis); CESC cis rs34375054 0.660 rs57491100 chr12:125593010 C/T cg25124228 chr12:125621409 AACS -0.56 -6.63 -0.38 1.84e-10 Post bronchodilator FEV1/FVC ratio; CESC cis rs1728785 1.000 rs1170443 chr16:68573295 G/C cg02972257 chr16:68554789 NA -0.55 -6.34 -0.36 9.7e-10 Ulcerative colitis; CESC cis rs7474896 0.526 rs1742235 chr10:38052256 T/C cg25427524 chr10:38739819 LOC399744 -0.48 -5.26 -0.31 3.05e-7 Obesity (extreme); CESC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg18876405 chr7:65276391 NA -0.49 -6.83 -0.39 5.72e-11 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11530914 chr16:67281528 FHOD1;SLC9A5 -0.44 -6.55 -0.37 3.06e-10 Gambling; CESC trans rs2900976 0.773 rs4638819 chr2:71995202 A/T cg01646268 chr11:14367071 RRAS2 -0.48 -6.31 -0.36 1.19e-9 Protein quantitative trait loci; CESC cis rs6964587 1.000 rs10264666 chr7:91578639 G/A cg17063962 chr7:91808500 NA -0.54 -7.12 -0.4 9.86e-12 Breast cancer; CESC cis rs1538970 0.816 rs34673142 chr1:45985561 G/A cg03146154 chr1:46216737 IPP 0.47 5.43 0.32 1.3e-7 Platelet count; CESC cis rs9487051 0.714 rs9487053 chr6:109619697 T/C cg01475377 chr6:109611718 NA -0.43 -6.68 -0.38 1.37e-10 Reticulocyte fraction of red cells; CESC cis rs7617773 0.817 rs13072018 chr3:48320332 G/A cg11946769 chr3:48343235 NME6 0.87 11.61 0.58 1.76e-25 Coronary artery disease; CESC cis rs7107174 1.000 rs7127187 chr11:77995188 G/A cg02023728 chr11:77925099 USP35 0.42 5.8 0.34 1.89e-8 Testicular germ cell tumor; CESC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg24549020 chr5:56110836 MAP3K1 0.47 5.86 0.34 1.35e-8 Initial pursuit acceleration; CESC cis rs5769765 1.000 rs768618 chr22:50286827 G/A cg26441486 chr22:50317300 CRELD2 0.38 5.37 0.31 1.77e-7 Schizophrenia; CESC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg04267008 chr7:1944627 MAD1L1 -0.59 -7.39 -0.41 1.96e-12 Bipolar disorder and schizophrenia; CESC cis rs16910800 0.731 rs56768542 chr11:23191946 A/G cg20040320 chr11:23191996 NA -0.67 -6.66 -0.38 1.53e-10 Cancer; CESC cis rs8177179 0.565 rs4355280 chr3:133468425 A/G cg24879335 chr3:133465180 TF 0.34 5.84 0.34 1.49e-8 Iron status biomarkers (transferrin levels); CESC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg24399712 chr22:39784796 NA -0.81 -11.13 -0.56 7.1e-24 Intelligence (multi-trait analysis); CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg00810945 chr16:21964237 UQCRC2 0.46 6.21 0.36 2.08e-9 Weight; CESC cis rs738322 0.775 rs13056506 chr22:38580917 G/T cg17652424 chr22:38574118 PLA2G6 0.3 5.15 0.3 5.07e-7 Cutaneous nevi; CESC cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg10057126 chr4:77819792 ANKRD56 0.58 8.4 0.46 2.79e-15 Emphysema distribution in smoking; CESC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg06481639 chr22:41940642 POLR3H -0.63 -6.28 -0.36 1.39e-9 Vitiligo; CESC cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg07636037 chr3:49044803 WDR6 1.08 19.57 0.77 2.17e-53 Parkinson's disease; CESC cis rs12780046 0.536 rs4919291 chr10:101062614 G/A cg27143070 chr10:101087766 CNNM1 0.36 5.37 0.31 1.72e-7 Non-glioblastoma glioma; CESC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg11890956 chr21:40555474 PSMG1 -0.95 -15.39 -0.69 1.26e-38 Cognitive function; CESC cis rs1707322 1.000 rs4298677 chr1:46306619 G/A cg05343316 chr1:45956843 TESK2 0.43 5.22 0.31 3.55e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11758351 0.660 rs16891455 chr6:26230485 G/A cg23601095 chr6:26197514 HIST1H3D 0.91 9.96 0.52 4.64e-20 Gout;Renal underexcretion gout; CESC cis rs6430585 0.528 rs7573555 chr2:136694905 C/T cg07169764 chr2:136633963 MCM6 -1.27 -20.1 -0.78 3.18e-55 Corneal structure; CESC cis rs5753618 0.583 rs71324184 chr22:31752061 C/G cg02404636 chr22:31891804 SFI1 0.44 6.48 0.37 4.57e-10 Colorectal cancer; CESC cis rs7107174 1.000 rs10899485 chr11:78072383 C/T cg02023728 chr11:77925099 USP35 -0.38 -5.47 -0.32 1.05e-7 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16257685 chr13:76124267 UCHL3 -0.54 -6.01 -0.35 5.96e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07352798 chr5:141488591 NDFIP1 -0.42 -6.22 -0.36 1.98e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs919433 0.783 rs788011 chr2:198230771 A/G cg10820045 chr2:198174542 NA 0.41 5.93 0.34 9.6e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs6696846 0.740 rs11240369 chr1:205115099 G/A cg00857998 chr1:205179979 DSTYK 0.57 7.45 0.42 1.28e-12 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11342415 chr10:1034284 GTPBP4 0.58 6.33 0.36 1.07e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.591 rs9615348 chr22:46729338 C/G cg18190219 chr22:46762943 CELSR1 -0.64 -5.89 -0.34 1.18e-8 LDL cholesterol;Cholesterol, total; CESC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg03576123 chr11:487126 PTDSS2 -1.04 -10.88 -0.56 4.82e-23 Body mass index; CESC cis rs9549260 0.604 rs56302456 chr13:41295887 G/T cg21288729 chr13:41239152 FOXO1 0.61 5.53 0.32 7.72e-8 Red blood cell count; CESC cis rs4728302 0.534 rs6976069 chr7:133152898 T/C cg10665199 chr7:133106180 EXOC4 0.52 7.21 0.4 5.91e-12 Intelligence;Intelligence (multi-trait analysis); CESC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg18016565 chr1:150552671 MCL1 0.34 5.28 0.31 2.67e-7 Tonsillectomy; CESC cis rs1400745 0.756 rs799683 chr14:35349236 G/A cg16230307 chr14:35515116 FAM177A1 0.44 5.24 0.31 3.35e-7 Monocyte count; CESC cis rs4713675 0.565 rs4713670 chr6:33699882 C/T cg14003231 chr6:33640908 ITPR3 -0.29 -5.1 -0.3 6.63e-7 Plateletcrit; CESC cis rs2637266 0.756 rs2245335 chr10:78553265 T/C cg18941641 chr10:78392320 NA 0.41 7.93 0.44 6.12e-14 Pulmonary function; CESC cis rs7191439 0.858 rs2290902 chr16:88782676 A/G cg27087555 chr16:88793112 FAM38A -1.17 -9.73 -0.51 2.47e-19 Plateletcrit; CESC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.78 0.65 6.16e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12497850 1.000 rs12497850 chr3:48748989 G/T cg06212747 chr3:49208901 KLHDC8B 0.61 8.07 0.44 2.45e-14 Parkinson's disease; CESC cis rs3126085 0.935 rs2184951 chr1:152273168 T/G cg03465714 chr1:152285911 FLG 0.51 5.87 0.34 1.32e-8 Atopic dermatitis; CESC cis rs752010 0.695 rs11210509 chr1:42109311 A/G cg06885757 chr1:42089581 HIVEP3 0.45 6.9 0.39 3.77e-11 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg03806693 chr22:41940476 POLR3H -0.97 -11.16 -0.57 6.04e-24 Vitiligo; CESC cis rs35110281 0.627 rs1836855 chr21:44965414 C/G cg01579765 chr21:45077557 HSF2BP -0.53 -8.95 -0.48 6.49e-17 Mean corpuscular volume; CESC cis rs208520 0.690 rs12201219 chr6:66748862 A/T cg07460842 chr6:66804631 NA 0.96 12.71 0.62 3.3e-29 Exhaled nitric oxide output; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02952711 chr10:134145586 LRRC27 -0.52 -6.9 -0.39 3.88e-11 Asthma; CESC cis rs1729951 0.575 rs12494558 chr3:136678781 C/G cg25687071 chr3:136751404 NA 0.39 5.22 0.31 3.66e-7 Neuroticism; CESC cis rs7255436 0.965 rs12981318 chr19:8451430 G/A cg10174797 chr19:8464628 RAB11B 0.39 5.57 0.32 6.11e-8 HDL cholesterol; CESC cis rs9443645 0.810 rs9443637 chr6:79714708 C/T cg05283184 chr6:79620031 NA -0.39 -6.2 -0.36 2.16e-9 Intelligence (multi-trait analysis); CESC cis rs2932538 0.922 rs17438324 chr1:113100573 C/T cg22162597 chr1:113214053 CAPZA1 0.57 7.11 0.4 1.1e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs4835473 0.932 rs4835013 chr4:144669638 C/T cg25736465 chr4:144833511 NA 0.37 5.74 0.33 2.59e-8 Immature fraction of reticulocytes; CESC cis rs10197940 0.638 rs2288193 chr2:152348842 T/A cg06191203 chr2:152266755 RIF1 -0.46 -5.21 -0.3 3.86e-7 Lung cancer; CESC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg13206674 chr6:150067644 NUP43 0.39 5.58 0.32 5.93e-8 Lung cancer; CESC cis rs8111998 0.826 rs6511364 chr19:22765808 C/T cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg05315796 chr3:52349193 DNAH1 0.3 5.34 0.31 2.01e-7 Electroencephalogram traits; CESC cis rs9309473 1.000 rs11899740 chr2:73631212 G/A cg20560298 chr2:73613845 ALMS1 -0.54 -7.0 -0.39 2.11e-11 Metabolite levels; CESC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs9309473 0.687 rs11126399 chr2:73613341 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.2 -0.36 2.2e-9 Metabolite levels; CESC cis rs6831352 0.918 rs7669636 chr4:100059312 G/A cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs748404 0.697 rs513970 chr15:43579566 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.36 0.46 3.69e-15 Lung cancer; CESC cis rs4481887 1.000 rs7525344 chr1:248467565 C/T cg00666640 chr1:248458726 OR2T12 -0.38 -6.62 -0.38 2.01e-10 Common traits (Other); CESC cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg03433033 chr1:76189801 ACADM 0.57 5.65 0.33 4.21e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11690935 1.000 rs3795999 chr2:172544483 A/G cg13550731 chr2:172543902 DYNC1I2 0.94 14.58 0.67 9.17e-36 Schizophrenia; CESC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg13206674 chr6:150067644 NUP43 0.45 6.53 0.37 3.37e-10 Lung cancer; CESC cis rs3754214 0.836 rs12023277 chr1:150466737 A/G cg09579323 chr1:150459698 TARS2 0.44 5.5 0.32 9e-8 Cerebrospinal fluid biomarker levels; CESC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg08888203 chr3:10149979 C3orf24 0.53 6.72 0.38 1.11e-10 Alzheimer's disease; CESC cis rs3806843 1.000 rs10057161 chr5:140156831 C/T cg26395211 chr5:140044315 WDR55 -0.42 -5.35 -0.31 1.92e-7 Depressive symptoms (multi-trait analysis); CESC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg00484396 chr16:3507460 NAT15 -0.58 -6.56 -0.37 2.88e-10 Tuberculosis; CESC cis rs1577917 0.876 rs1582127 chr6:86697204 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -5.59 -0.33 5.5e-8 Response to antipsychotic treatment; CESC cis rs17688076 0.511 rs2418738 chr16:68122604 G/C cg26727032 chr16:67993705 SLC12A4 -0.52 -6.3 -0.36 1.24e-9 C-reactive protein levels or HDL-cholesterol levels (pleiotropy); CESC cis rs892961 0.720 rs103458 chr17:75416031 A/G cg05865280 chr17:75406074 SEPT9 0.59 11.38 0.57 1.04e-24 Airflow obstruction; CESC cis rs965469 1.000 rs6037562 chr20:3326141 A/C cg25506879 chr20:3388711 C20orf194 -0.54 -5.78 -0.33 2.14e-8 IFN-related cytopenia; CESC cis rs1348850 0.914 rs1453370 chr2:178327727 C/T cg23306229 chr2:178417860 TTC30B 0.65 8.0 0.44 4e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06013127 chr17:27903940 GIT1 0.49 6.35 0.36 9.1e-10 Fibrinogen levels; CESC cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.52 6.55 0.37 3.02e-10 Tonsillectomy; CESC cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg05347473 chr6:146136440 FBXO30 -0.76 -9.65 -0.51 4.49e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs6446731 0.517 rs2071667 chr4:3269926 C/A cg08886695 chr4:3369023 RGS12 0.39 5.67 0.33 3.67e-8 Mean platelet volume; CESC cis rs17376456 1.000 rs17376456 chr5:93557702 C/T cg25358565 chr5:93447407 FAM172A -1.18 -10.75 -0.55 1.34e-22 Diabetic retinopathy; CESC cis rs7605827 0.930 rs4668923 chr2:15681227 G/A cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs6866344 0.697 rs62392823 chr5:178126968 T/C cg10224037 chr5:178157518 ZNF354A 0.67 7.38 0.41 2.09e-12 Neutrophil percentage of white cells; CESC cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.65 -0.43 3.85e-13 Alzheimer's disease; CESC cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs17376456 0.877 rs10055741 chr5:93297187 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.34 0.31 1.98e-7 Diabetic retinopathy; CESC cis rs734999 0.566 rs6664969 chr1:2534978 G/A cg18854424 chr1:2615690 NA 0.27 5.21 0.3 3.79e-7 Ulcerative colitis; CESC cis rs4820539 1.000 rs4820539 chr22:23477970 C/T cg14186256 chr22:23484241 RTDR1 -0.78 -13.93 -0.65 1.85e-33 Bone mineral density; CESC cis rs12497850 1.000 rs1352420 chr3:48757291 A/G cg02487422 chr3:49467188 NICN1 0.43 5.53 0.32 7.81e-8 Parkinson's disease; CESC cis rs9467711 0.606 rs66823108 chr6:26377939 G/A cg12826209 chr6:26865740 GUSBL1 0.64 5.21 0.3 3.77e-7 Autism spectrum disorder or schizophrenia; CESC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg16145915 chr7:1198662 ZFAND2A -0.5 -6.31 -0.36 1.18e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2204008 0.805 rs7296063 chr12:37964775 T/G cg13010199 chr12:38710504 ALG10B 0.52 6.55 0.37 3.01e-10 Bladder cancer; CESC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg15782153 chr7:917662 C7orf20 -0.47 -5.15 -0.3 5.12e-7 Cerebrospinal P-tau181p levels; CESC cis rs7818688 0.697 rs78088250 chr8:95972718 G/A cg16049864 chr8:95962084 TP53INP1 0.59 5.82 0.34 1.68e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs4660261 0.526 rs2040950 chr1:44315113 G/C cg13606994 chr1:44402422 ARTN -0.35 -5.16 -0.3 4.91e-7 Intelligence (multi-trait analysis); CESC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.81 0.48 1.71e-16 Bipolar disorder; CESC cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg20503657 chr10:835505 NA 0.65 7.18 0.4 6.99e-12 Eosinophil percentage of granulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10692753 chr16:23464628 COG7 -0.42 -6.03 -0.35 5.55e-9 Gut microbiota (bacterial taxa); CESC cis rs7296418 0.961 rs11608811 chr12:123529056 A/G cg00376283 chr12:123451042 ABCB9 0.74 10.79 0.55 9.42e-23 Platelet count; CESC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg24578937 chr1:2090814 PRKCZ -0.34 -5.73 -0.33 2.66e-8 Height; CESC cis rs57221529 0.766 rs17497684 chr5:558307 T/C cg16447950 chr5:562315 NA -0.7 -7.76 -0.43 1.9e-13 Lung disease severity in cystic fibrosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03992926 chr1:186344761 TPR;C1orf27;MIR548F1 0.59 6.92 0.39 3.33e-11 Gut microbiome composition (summer); CESC cis rs35995292 0.534 rs28460817 chr7:38921917 T/C cg19327137 chr7:38886074 VPS41 0.65 10.74 0.55 1.38e-22 Subjective well-being (multi-trait analysis); CESC cis rs593982 0.719 rs555903 chr11:65466911 G/A cg08755490 chr11:65554678 OVOL1 -1.16 -10.39 -0.54 2.03e-21 Atopic dermatitis; CESC cis rs1395 0.778 rs60631624 chr2:27497815 T/G cg22903471 chr2:27725779 GCKR -0.5 -6.11 -0.35 3.47e-9 Blood metabolite levels; CESC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg20607287 chr7:12443886 VWDE -0.77 -9.04 -0.49 3.38e-17 Coronary artery disease; CESC cis rs9486719 0.948 rs2092095 chr6:96870864 T/G cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg22875332 chr1:76189707 ACADM -0.6 -6.39 -0.37 7.37e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3008870 1.000 rs2815370 chr1:67503727 A/G cg02640540 chr1:67518911 SLC35D1 -0.53 -5.73 -0.33 2.7e-8 Lymphocyte percentage of white cells; CESC trans rs9325144 0.647 rs12830095 chr12:38864199 C/T cg23762105 chr12:34175262 ALG10 0.46 6.04 0.35 5.3e-9 Morning vs. evening chronotype; CESC cis rs8017423 0.967 rs11627528 chr14:90719697 C/A cg14092571 chr14:90743983 NA 0.57 8.73 0.47 2.9e-16 Mortality in heart failure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17400366 chr19:10420311 ZGLP1 -0.54 -6.66 -0.38 1.53e-10 Gut microbiome composition (summer); CESC trans rs4904167 0.841 rs12717596 chr14:84685302 A/C cg06870609 chr15:89787223 FANCI 0.46 6.06 0.35 4.73e-9 Autism spectrum disorder or schizophrenia; CESC trans rs7690543 0.581 rs1364982 chr4:67995472 A/G cg05505961 chr17:66375071 ARSG -0.51 -6.1 -0.35 3.79e-9 Glucose homeostasis traits; CESC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg02725872 chr8:58115012 NA -0.36 -5.79 -0.34 1.98e-8 Developmental language disorder (linguistic errors); CESC cis rs11764590 0.724 rs55789728 chr7:2107649 A/G cg21782813 chr7:2030301 MAD1L1 -0.4 -5.16 -0.3 4.81e-7 Neuroticism; CESC cis rs16921914 0.559 rs2985140 chr11:31315886 C/T cg14844989 chr11:31128820 NA 0.38 5.3 0.31 2.42e-7 Bone mineral density (spine); CESC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg11301795 chr4:187892539 NA 0.74 10.98 0.56 2.26e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.47 -6.54 -0.37 3.19e-10 Menopause (age at onset); CESC cis rs12477438 0.666 rs10179910 chr2:99658503 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -7.87 -0.44 8.99e-14 Chronic sinus infection; CESC cis rs12973672 0.812 rs28365133 chr19:35761519 A/G cg12095397 chr19:35769544 USF2 0.49 5.83 0.34 1.59e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7267979 1.000 rs448396 chr20:25440269 G/A cg08601574 chr20:25228251 PYGB 0.37 5.31 0.31 2.31e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs1814175 0.645 rs1874969 chr11:49826700 G/A cg15704280 chr7:45808275 SEPT13 -0.98 -17.89 -0.74 1.8e-47 Height; CESC cis rs4972806 0.849 rs2857541 chr2:177029086 C/T cg13092806 chr2:177043255 NA 0.46 6.87 0.39 4.45e-11 IgG glycosylation; CESC cis rs4808199 0.689 rs12979148 chr19:19406869 T/C cg03709012 chr19:19516395 GATAD2A 0.96 8.23 0.45 8.42e-15 Nonalcoholic fatty liver disease; CESC cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -6.61 -0.38 2.08e-10 Hemoglobin concentration; CESC cis rs7089973 0.584 rs758585 chr10:116582560 C/A cg25233709 chr10:116636983 FAM160B1 0.36 5.82 0.34 1.65e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2243480 0.901 rs34807232 chr7:65965133 G/A cg13147721 chr7:65941812 NA -0.95 -8.98 -0.48 4.99e-17 Diabetic kidney disease; CESC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.84 0.34 1.55e-8 Tonsillectomy; CESC cis rs6088590 0.561 rs6059934 chr20:33178324 G/T cg06115741 chr20:33292138 TP53INP2 0.53 6.88 0.39 4.32e-11 Coronary artery disease; CESC cis rs6499129 0.558 rs9934328 chr16:67573367 G/C cg26727032 chr16:67993705 SLC12A4 -0.59 -7.21 -0.41 5.67e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2073300 1.000 rs2207988 chr20:23446000 C/A cg12062639 chr20:23401060 NAPB 0.74 5.43 0.32 1.3e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08478283 chr1:117076803 CD58 -0.74 -8.79 -0.48 1.96e-16 Gut microbiome composition (summer); CESC cis rs501120 0.657 rs494207 chr10:44741256 G/A cg09554077 chr10:44749378 NA 0.43 5.16 0.3 4.85e-7 Coronary artery disease;Coronary heart disease; CESC cis rs6547741 1.000 rs6750943 chr2:27777904 T/G cg27432699 chr2:27873401 GPN1 0.49 6.94 0.39 2.93e-11 Oral cavity cancer; CESC cis rs17253792 0.822 rs28392709 chr14:56093685 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs2439831 0.850 rs7163245 chr15:43671294 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.92 11.23 0.57 3.34e-24 Lung cancer in ever smokers; CESC cis rs6866344 0.570 rs6896799 chr5:178147014 G/C cg03877680 chr5:178157825 ZNF354A 0.81 9.75 0.51 2.09e-19 Neutrophil percentage of white cells; CESC cis rs2857078 0.627 rs1476512 chr17:42330122 C/T cg13607699 chr17:42295918 UBTF -0.65 -9.32 -0.5 4.77e-18 Red cell distribution width;Reticulocyte count; CESC cis rs12618769 0.625 rs4850877 chr2:99112154 C/T cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg10691866 chr7:65817282 TPST1 0.33 5.47 0.32 1.02e-7 Aortic root size; CESC cis rs3733585 0.673 rs4560411 chr4:9953361 A/G cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1178968 1.000 rs2237285 chr7:72760213 C/T cg25889504 chr7:72793014 NA 0.48 5.08 0.3 7.22e-7 Triglyceride levels; CESC cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg11657440 chr19:46296263 DMWD 0.78 11.83 0.59 3.36e-26 Coronary artery disease; CESC cis rs6495122 0.532 rs2470890 chr15:75047426 C/T cg14664628 chr15:75095509 CSK -0.62 -7.99 -0.44 4.12e-14 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs2040771 0.872 rs12485084 chr22:19162326 A/G cg02655711 chr22:19163373 SLC25A1 0.42 6.15 0.35 2.87e-9 Metabolite levels (small molecules and protein measures); CESC trans rs837841 0.864 rs1660903 chr2:130046679 C/G cg05301181 chr10:35379533 CUL2 -0.46 -6.05 -0.35 4.94e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs28647808 1.000 rs28478220 chr9:136273312 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC trans rs527616 0.793 rs675150 chr18:24339719 C/T cg05106058 chr4:172735924 GALNTL6 0.4 6.28 0.36 1.38e-9 Breast cancer; CESC cis rs5758659 0.967 rs5758670 chr22:42636687 T/C cg15557168 chr22:42548783 NA -0.49 -7.82 -0.43 1.28e-13 Cognitive function; CESC trans rs116095464 0.558 rs73031482 chr5:227594 G/A cg00938859 chr5:1591904 SDHAP3 0.61 6.75 0.38 9.06e-11 Breast cancer; CESC cis rs3741798 1.000 rs61922049 chr12:12497395 C/T cg08615371 chr12:12503544 MANSC1 0.79 5.65 0.33 4.22e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7429990 0.932 rs6770477 chr3:48019258 A/G cg11946769 chr3:48343235 NME6 -0.44 -5.38 -0.31 1.65e-7 Educational attainment (years of education); CESC trans rs35110281 0.744 rs162398 chr21:44949285 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.57 0.37 2.65e-10 Mean corpuscular volume; CESC cis rs2191566 0.664 rs3810406 chr19:44556381 G/T cg20607764 chr19:44506953 ZNF230 -0.44 -5.64 -0.33 4.34e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs2997447 0.761 rs74384164 chr1:26430379 C/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.6 5.14 0.3 5.43e-7 QRS complex (12-leadsum); CESC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.93 0.39 3.13e-11 Bipolar disorder; CESC cis rs6433857 0.657 rs10209994 chr2:181514955 A/C cg23363182 chr2:181467187 NA -0.46 -6.58 -0.37 2.49e-10 Body mass index; CESC cis rs9814567 1.000 rs6806417 chr3:134211446 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.41 5.76 0.33 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs8068544 0.818 rs7209012 chr17:40161323 C/T cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.94 -8.43 -0.46 2.27e-15 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs8077577 0.708 rs3829589 chr17:18134266 T/C cg16794390 chr17:18148240 FLII -0.44 -6.58 -0.37 2.46e-10 Obesity-related traits; CESC cis rs4332037 0.539 rs11764780 chr7:2020904 G/C cg23422044 chr7:1970798 MAD1L1 -0.5 -5.38 -0.31 1.61e-7 Bipolar disorder; CESC cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg20503657 chr10:835505 NA 0.8 8.18 0.45 1.16e-14 Eosinophil percentage of granulocytes; CESC cis rs6570726 1.000 rs455109 chr6:145872665 C/T cg05347473 chr6:146136440 FBXO30 0.43 5.83 0.34 1.63e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg06263672 chr7:65235340 NA 0.4 5.09 0.3 6.86e-7 Calcium levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24951396 chr12:125473687 DHX37 -0.46 -6.28 -0.36 1.38e-9 Gut microbiota (bacterial taxa); CESC cis rs6088580 0.634 rs7271970 chr20:32987666 A/G cg06115741 chr20:33292138 TP53INP2 -0.47 -6.08 -0.35 4.13e-9 Glomerular filtration rate (creatinine); CESC cis rs16854884 0.657 rs12107291 chr3:143739547 T/C cg06585982 chr3:143692056 C3orf58 0.5 6.71 0.38 1.18e-10 Economic and political preferences (feminism/equality); CESC cis rs17376456 0.877 rs12716456 chr5:93397557 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.36 0.31 1.8e-7 Diabetic retinopathy; CESC cis rs2120019 0.935 rs34913788 chr15:75372617 A/C cg09165964 chr15:75287851 SCAMP5 -0.67 -8.12 -0.45 1.76e-14 Blood trace element (Zn levels); CESC cis rs2228479 0.850 rs11649100 chr16:89798179 A/G cg14709524 chr16:89940631 TCF25 0.78 5.43 0.32 1.3e-7 Skin colour saturation; CESC cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.75 9.12 0.49 1.99e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs2108225 0.714 rs929394 chr7:107437252 C/T cg18560240 chr7:107437656 SLC26A3 -0.52 -7.22 -0.41 5.37e-12 Ulcerative colitis; CESC cis rs5758659 0.904 rs5758653 chr22:42613485 G/T cg04733989 chr22:42467013 NAGA 0.42 5.75 0.33 2.51e-8 Cognitive function; CESC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg04369109 chr6:150039330 LATS1 -0.49 -6.73 -0.38 1.02e-10 Lung cancer; CESC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg18225595 chr11:63971243 STIP1 -0.52 -7.3 -0.41 3.3e-12 Platelet count; CESC cis rs9814567 1.000 rs6763088 chr3:134254989 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg23982607 chr1:1823379 GNB1 -0.76 -12.36 -0.6 5.22e-28 Body mass index; CESC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.71e-40 Aortic root size; CESC cis rs2408955 0.568 rs12099462 chr12:48503104 T/C cg24011408 chr12:48396354 COL2A1 -0.5 -7.63 -0.42 4.35e-13 Glycated hemoglobin levels; CESC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg05552183 chr6:42928497 GNMT 0.73 10.99 0.56 2.09e-23 Alzheimer's disease in APOE e4+ carriers; CESC cis rs17608059 0.710 rs8080167 chr17:13949828 G/A cg27005118 chr17:13972210 COX10 -0.37 -5.62 -0.33 4.91e-8 Temperament; CESC cis rs6540559 0.611 rs76766079 chr1:209997731 C/T cg21951975 chr1:209979733 IRF6 0.59 6.72 0.38 1.1e-10 Cleft lip with or without cleft palate; CESC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -6.92 -0.39 3.47e-11 Personality dimensions; CESC cis rs1707322 1.000 rs11211204 chr1:46317864 A/G cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg07870213 chr5:140052090 DND1 0.65 6.81 0.39 6.37e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg14829155 chr15:31115871 NA -0.53 -7.27 -0.41 4.08e-12 Huntington's disease progression; CESC cis rs1691799 0.831 rs6581678 chr12:66776656 A/G cg16791601 chr12:66731901 HELB -0.74 -13.0 -0.62 3.21e-30 White blood cell count (basophil); CESC cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg06212747 chr3:49208901 KLHDC8B 0.73 9.73 0.51 2.47e-19 Parkinson's disease; CESC cis rs7208859 0.562 rs11650923 chr17:29008167 G/A cg14008862 chr17:28927542 LRRC37B2 0.73 5.8 0.34 1.92e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11683229 0.777 rs4671052 chr2:63139305 C/T cg17519650 chr2:63277830 OTX1 0.68 5.88 0.34 1.25e-8 Protein quantitative trait loci; CESC cis rs72781680 1.000 rs7355559 chr2:24256946 G/T cg08917208 chr2:24149416 ATAD2B -0.8 -7.63 -0.42 4.21e-13 Lymphocyte counts; CESC cis rs7312774 0.748 rs12308071 chr12:107314539 T/A cg16260113 chr12:107380972 MTERFD3 0.66 6.13 0.35 3.17e-9 Severe influenza A (H1N1) infection; CESC trans rs2121875 0.638 rs10941660 chr5:44223787 G/C cg09056876 chr6:156718398 NA -0.48 -6.23 -0.36 1.8e-9 Prostate cancer; CESC cis rs12477438 0.520 rs4588238 chr2:99749350 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.81 0.7 4.17e-40 Chronic sinus infection; CESC cis rs6785206 0.892 rs6793907 chr3:128391626 A/G cg16766828 chr3:128327626 NA 0.58 6.67 0.38 1.53e-10 Lymphocyte percentage of white cells; CESC cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.63 7.77 0.43 1.76e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs72945132 0.882 rs7116059 chr11:70159690 G/T cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27445386 chr6:42897250 CNPY3 0.56 6.81 0.39 6.59e-11 Gut microbiome composition (summer); CESC cis rs10782582 0.593 rs4646960 chr1:76211103 C/A cg22875332 chr1:76189707 ACADM -0.45 -5.32 -0.31 2.19e-7 Daytime sleep phenotypes; CESC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg24881330 chr22:46731750 TRMU 0.81 7.26 0.41 4.22e-12 LDL cholesterol;Cholesterol, total; CESC cis rs9430161 0.579 rs11121669 chr1:11039567 T/C cg27631724 chr1:11040367 C1orf127 0.43 7.31 0.41 3.13e-12 Ewing sarcoma; CESC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg06877462 chr1:205807181 PM20D1 0.35 5.09 0.3 6.81e-7 Menarche (age at onset); CESC cis rs9814567 1.000 rs6772896 chr3:134203347 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.03 -0.35 5.44e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25675027 chr19:1119071 SBNO2 0.44 6.34 0.36 9.65e-10 Gambling; CESC cis rs3806843 0.735 rs6849 chr5:140086191 G/T cg26395211 chr5:140044315 WDR55 0.48 6.13 0.35 3.17e-9 Depressive symptoms (multi-trait analysis); CESC cis rs1538970 0.961 rs884962 chr1:45847981 G/A cg05343316 chr1:45956843 TESK2 0.83 11.7 0.58 8.81e-26 Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03144560 chr20:55043299 C20orf43 -0.41 -6.08 -0.35 4.12e-9 Fibrinogen levels; CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg26668828 chr6:292823 DUSP22 -0.72 -9.34 -0.5 4.23e-18 Menopause (age at onset); CESC cis rs116095464 0.681 rs10060016 chr5:241100 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.63 -0.47 5.66e-16 Breast cancer; CESC cis rs7537052 0.669 rs2296263 chr1:36641729 C/T cg24686825 chr1:36642396 MAP7D1 -0.57 -8.29 -0.45 5.68e-15 Schizophrenia; CESC cis rs12530134 0.523 rs7762088 chr6:170794570 T/C cg16453901 chr6:170730693 NA -0.85 -5.97 -0.34 7.74e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs826838 0.967 rs11168985 chr12:39045983 A/C cg26384229 chr12:38710491 ALG10B -0.81 -13.45 -0.64 8.46e-32 Heart rate; CESC cis rs116095464 0.558 rs1541822 chr5:269234 A/C cg12570787 chr5:219185 SDHA;CCDC127 -0.51 -5.33 -0.31 2.09e-7 Breast cancer; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg12595990 chr12:49351331 ARF3 0.48 6.09 0.35 4.05e-9 Psoriatic arthritis; CESC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg02569458 chr12:86230093 RASSF9 0.48 7.15 0.4 8.31e-12 Major depressive disorder; CESC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg19717773 chr7:2847554 GNA12 -0.53 -7.63 -0.42 4.19e-13 Height; CESC cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 3.05e-8 Mean platelet volume; CESC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.46 -5.63 -0.33 4.62e-8 Tuberculosis; CESC cis rs9527 0.590 rs12775302 chr10:104911356 A/G cg04362960 chr10:104952993 NT5C2 0.43 5.33 0.31 2.12e-7 Arsenic metabolism; CESC cis rs11122272 0.705 rs2808599 chr1:231533482 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs10779751 0.649 rs1318348 chr1:11130418 A/G cg08854313 chr1:11322531 MTOR 0.76 10.26 0.53 4.97e-21 Body mass index; CESC cis rs7953508 0.711 rs11107116 chr12:93978504 G/T cg18151635 chr12:93972918 NA -0.37 -5.06 -0.3 7.76e-7 Pubertal anthropometrics; CESC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg05564831 chr3:52568323 NT5DC2 0.45 6.75 0.38 9.12e-11 Bipolar disorder; CESC cis rs9487051 0.676 rs4406271 chr6:109598213 G/A cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.03e-9 Aortic root size; CESC cis rs9583531 0.600 rs1441042 chr13:111365589 T/G cg24331049 chr13:111365604 ING1 0.82 12.31 0.6 7.59e-28 Coronary artery disease; CESC cis rs11997175 0.655 rs7833512 chr8:33662884 C/T ch.8.33884649F chr8:33765107 NA 0.46 5.85 0.34 1.45e-8 Body mass index; CESC cis rs7089973 0.523 rs11197017 chr10:116737738 C/A cg23260525 chr10:116636907 FAM160B1 0.3 5.19 0.3 4.1e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs854765 0.663 rs4925120 chr17:17754633 C/T cg04398451 chr17:18023971 MYO15A 0.63 9.17 0.49 1.39e-17 Total body bone mineral density; CESC cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg16447950 chr5:562315 NA -0.62 -6.52 -0.37 3.51e-10 Lung disease severity in cystic fibrosis; CESC cis rs6580649 0.943 rs9651993 chr12:48404692 G/A cg24011408 chr12:48396354 COL2A1 0.41 5.08 0.3 7.17e-7 Lung cancer; CESC trans rs11098499 0.863 rs12502389 chr4:120454191 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.47e-19 Corneal astigmatism; CESC cis rs3820928 0.874 rs2177593 chr2:227833869 G/A cg11843606 chr2:227700838 RHBDD1 -0.45 -5.74 -0.33 2.65e-8 Pulmonary function; CESC cis rs2502731 0.539 rs3003615 chr9:130997892 C/T cg13642260 chr9:130955380 CIZ1 0.46 6.74 0.38 9.57e-11 Attention deficit hyperactivity disorder; CESC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg11764359 chr7:65958608 NA -0.78 -11.22 -0.57 3.73e-24 Aortic root size; CESC cis rs1050631 0.592 rs1785933 chr18:33719191 T/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.53 7.16 0.4 7.87e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg22974920 chr21:40686053 BRWD1 -0.45 -5.61 -0.33 4.99e-8 Cognitive function; CESC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg07952391 chr2:88470173 THNSL2 -0.52 -7.76 -0.43 1.9e-13 Response to metformin (IC50); CESC cis rs11690935 0.632 rs6723259 chr2:172622527 A/C cg13550731 chr2:172543902 DYNC1I2 0.65 8.96 0.48 5.89e-17 Schizophrenia; CESC cis rs7615952 0.932 rs3811679 chr3:125648283 A/G cg05084668 chr3:125655381 ALG1L -0.52 -6.04 -0.35 5.27e-9 Blood pressure (smoking interaction); CESC cis rs6963495 0.818 rs55691539 chr7:105165774 T/C cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 6.05 0.35 4.83e-9 Tonsillectomy; CESC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.44 6.24 0.36 1.71e-9 Menopause (age at onset); CESC cis rs3780486 0.541 rs10738909 chr9:33148834 T/C cg13443165 chr9:33130375 B4GALT1 0.48 7.35 0.41 2.46e-12 IgG glycosylation; CESC cis rs11098499 0.779 rs10857066 chr4:120286596 C/T cg09307838 chr4:120376055 NA 0.88 12.21 0.6 1.7e-27 Corneal astigmatism; CESC cis rs35110281 0.666 rs2838348 chr21:45107285 C/G cg21573476 chr21:45109991 RRP1B 0.57 8.35 0.46 3.76e-15 Mean corpuscular volume; CESC cis rs6963495 0.818 rs73190183 chr7:105163022 G/A cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18936800 chr18:44676962 HDHD2 0.58 6.33 0.36 1.04e-9 Gut microbiome composition (summer); CESC cis rs6912958 0.605 rs2754247 chr6:88383571 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -5.22 -0.31 3.59e-7 Monocyte percentage of white cells; CESC cis rs2929278 0.617 rs694461 chr15:44096063 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.45 -7.06 -0.4 1.43e-11 Schizophrenia; CESC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg24642844 chr7:1081250 C7orf50 -0.67 -8.66 -0.47 4.82e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4930103 0.874 rs80047492 chr11:2025032 A/T cg23202291 chr11:1979235 NA 0.39 5.78 0.33 2.11e-8 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs727505 0.954 rs66871687 chr7:124670475 A/G cg23710748 chr7:124431027 NA -0.42 -6.62 -0.38 1.97e-10 Lewy body disease; CESC cis rs360798 0.553 rs360804 chr2:62939397 C/T cg17519650 chr2:63277830 OTX1 -0.53 -6.19 -0.36 2.28e-9 Coronary artery disease; CESC cis rs1425132 0.642 rs1346019 chr7:37589526 A/G cg15028436 chr7:37888078 TXNDC3 -0.31 -5.26 -0.31 2.95e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin); CESC trans rs11039798 1.000 rs3902927 chr11:48581457 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.21 0.36 2.01e-9 Axial length; CESC trans rs319204 0.843 rs178549 chr5:146295990 A/G cg01189915 chr7:128095027 C7orf68 -0.35 -6.1 -0.35 3.81e-9 Schizophrenia; CESC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Parkinson's disease; CESC cis rs7809950 1.000 rs2520265 chr7:107181231 A/G cg23024343 chr7:107201750 COG5 -0.42 -5.83 -0.34 1.64e-8 Coronary artery disease; CESC cis rs4664304 0.708 rs7564243 chr2:160726868 G/A cg03641300 chr2:160917029 PLA2R1 -0.41 -5.41 -0.32 1.44e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs763121 0.853 rs5757141 chr22:38957483 G/A cg06544989 chr22:39130855 UNC84B 0.48 7.97 0.44 4.62e-14 Menopause (age at onset); CESC cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg12386194 chr3:101231763 SENP7 0.44 5.45 0.32 1.15e-7 Colorectal cancer; CESC cis rs17095355 1.000 rs11194940 chr10:111742223 G/A cg00817464 chr10:111662876 XPNPEP1 -0.45 -5.37 -0.31 1.73e-7 Biliary atresia; CESC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg04414720 chr1:150670196 GOLPH3L 0.6 8.77 0.47 2.28e-16 Urate levels; CESC cis rs2637266 0.597 rs846615 chr10:78548489 A/G cg18941641 chr10:78392320 NA -0.4 -7.55 -0.42 7.04e-13 Pulmonary function; CESC cis rs2425143 0.730 rs6579259 chr20:34462550 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.7 0.33 3.16e-8 Blood protein levels; CESC cis rs8017423 0.967 rs61231898 chr14:90691696 G/A cg14092571 chr14:90743983 NA -0.57 -8.19 -0.45 1.13e-14 Mortality in heart failure; CESC cis rs7246657 0.943 rs10404920 chr19:37881556 T/C cg23950597 chr19:37808831 NA -0.61 -6.18 -0.35 2.39e-9 Coronary artery calcification; CESC cis rs7851660 0.967 rs3758249 chr9:100614140 T/C cg13688889 chr9:100608707 NA -0.68 -10.54 -0.54 6.55e-22 Strep throat; CESC cis rs10504229 0.906 rs2270609 chr8:58194684 G/A cg05313129 chr8:58192883 C8orf71 -0.53 -6.07 -0.35 4.46e-9 Developmental language disorder (linguistic errors); CESC cis rs34375054 0.526 rs2343638 chr12:125677122 G/C cg00522288 chr12:125625016 AACS -0.33 -5.14 -0.3 5.44e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs72945132 0.882 rs11235967 chr11:70191691 T/C cg00319359 chr11:70116639 PPFIA1 0.71 6.87 0.39 4.68e-11 Coronary artery disease; CESC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg14262678 chr6:151773367 RMND1;C6orf211 -0.68 -9.35 -0.5 3.88e-18 Menarche (age at onset); CESC cis rs7582720 1.000 rs114702158 chr2:203821793 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs11690935 0.885 rs6727017 chr2:172766847 T/A cg13550731 chr2:172543902 DYNC1I2 -0.86 -12.68 -0.61 4.03e-29 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07423838 chr7:73062350 NA 0.49 6.29 0.36 1.28e-9 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23173032 chr14:50359789 ARF6 0.59 6.98 0.39 2.33e-11 Gut microbiome composition (summer); CESC cis rs7312774 0.618 rs4964510 chr12:107357251 A/G cg16260113 chr12:107380972 MTERFD3 0.93 7.52 0.42 8.77e-13 Severe influenza A (H1N1) infection; CESC cis rs72781680 0.612 rs33913065 chr2:24344060 T/G cg20701182 chr2:24300061 SF3B14 0.92 10.62 0.55 3.63e-22 Lymphocyte counts; CESC cis rs11190604 1.000 rs11190589 chr10:102275471 A/G cg07080220 chr10:102295463 HIF1AN 0.66 6.16 0.35 2.7e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs847577 0.748 rs55784506 chr7:97718201 G/A cg21770322 chr7:97807741 LMTK2 0.64 10.36 0.54 2.38e-21 Breast cancer; CESC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.29 0.31 2.62e-7 Electroencephalogram traits; CESC cis rs3106136 0.967 rs12643901 chr4:95145132 C/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.01 -0.4 1.94e-11 Capecitabine sensitivity; CESC cis rs17376456 0.504 rs6898507 chr5:93082343 C/T cg25358565 chr5:93447407 FAM172A 0.68 7.24 0.41 5.01e-12 Diabetic retinopathy; CESC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Depression; CESC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg09913183 chr17:42254507 C17orf65;ASB16 0.74 10.2 0.53 8.14e-21 Total body bone mineral density; CESC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 9.96 0.52 4.61e-20 Platelet count; CESC cis rs473651 0.904 rs62196716 chr2:239356977 C/G cg18131467 chr2:239335373 ASB1 0.99 20.18 0.78 1.72e-55 Multiple system atrophy; CESC cis rs1975974 0.511 rs66766425 chr17:21755307 G/T cg18423549 chr17:21743878 NA -0.72 -9.92 -0.52 6.1e-20 Psoriasis; CESC cis rs10789491 1.000 rs1258061 chr1:47105000 G/A cg15501359 chr1:47185051 KIAA0494 -0.79 -8.66 -0.47 4.78e-16 Response to hepatitis C treatment; CESC cis rs9322193 0.607 rs12527391 chr6:150203292 T/C cg01145232 chr6:150245071 RAET1G 0.52 6.52 0.37 3.49e-10 Lung cancer; CESC cis rs9815354 1.000 rs73079321 chr3:41863910 C/T cg03022575 chr3:42003672 ULK4 0.49 5.52 0.32 7.99e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs17376456 0.825 rs13161885 chr5:93071242 A/C cg21475434 chr5:93447410 FAM172A 0.85 7.25 0.41 4.66e-12 Diabetic retinopathy; CESC cis rs1048238 0.506 rs848194 chr1:16285342 G/A cg22431228 chr1:16359049 CLCNKA 0.37 6.2 0.36 2.1e-9 Systolic blood pressure; CESC cis rs938554 0.744 rs7675964 chr4:9941434 C/T cg11266682 chr4:10021025 SLC2A9 -0.37 -5.89 -0.34 1.18e-8 Blood metabolite levels; CESC cis rs909674 0.775 rs4821896 chr22:39833437 T/C cg05872129 chr22:39784769 NA -0.78 -10.4 -0.54 1.8e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9303401 0.659 rs62083362 chr17:56846464 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.5 0.61 1.71e-28 Cognitive test performance; CESC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.47 0.77 5.16e-53 Height; CESC cis rs2952156 0.883 rs12150603 chr17:37834715 G/A cg00129232 chr17:37814104 STARD3 -0.78 -11.63 -0.58 1.51e-25 Asthma; CESC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg20887711 chr4:1340912 KIAA1530 0.77 10.4 0.54 1.88e-21 Longevity; CESC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg07936489 chr17:37558343 FBXL20 0.77 10.54 0.54 6.54e-22 Glomerular filtration rate (creatinine); CESC cis rs3015497 0.603 rs3015443 chr14:51085208 C/T cg26011998 chr14:51135199 SAV1 -0.48 -5.35 -0.31 1.92e-7 Mean platelet volume; CESC cis rs10504073 0.647 rs4873098 chr8:50021041 T/C cg00325661 chr8:49890786 NA 0.5 7.7 0.43 2.68e-13 Blood metabolite ratios; CESC trans rs561341 1.000 rs72821952 chr17:30248133 T/A cg20587970 chr11:113659929 NA -1.4 -16.86 -0.72 7.67e-44 Hip circumference adjusted for BMI; CESC cis rs7301826 0.603 rs7975825 chr12:131288444 C/T cg11011512 chr12:131303247 STX2 0.45 5.44 0.32 1.2e-7 Plasma plasminogen activator levels; CESC cis rs9300255 0.602 rs1716167 chr12:123651162 C/T cg05973401 chr12:123451056 ABCB9 -0.51 -5.79 -0.34 1.94e-8 Neutrophil percentage of white cells; CESC cis rs9457247 0.935 rs2757050 chr6:167377165 G/T cg25258033 chr6:167368657 RNASET2 -0.42 -6.25 -0.36 1.63e-9 Crohn's disease; CESC cis rs9457247 0.508 rs2285147 chr6:167505548 G/A cg23791538 chr6:167370224 RNASET2 -0.49 -6.42 -0.37 6.12e-10 Crohn's disease; CESC cis rs12497850 0.931 rs3774628 chr3:48801840 C/T cg06641503 chr3:48959341 ARIH2 -0.33 -5.08 -0.3 7.01e-7 Parkinson's disease; CESC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg11494091 chr17:61959527 GH2 0.73 12.69 0.61 3.77e-29 Prudent dietary pattern; CESC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.46 0.42 1.24e-12 Tonsillectomy; CESC cis rs17253792 0.822 rs28754619 chr14:56088394 G/A cg01858014 chr14:56050164 KTN1 -0.83 -7.03 -0.4 1.7e-11 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05379947 chr6:35436047 RPL10A 0.6 6.98 0.39 2.36e-11 Gut microbiome composition (summer); CESC cis rs12597458 0.763 rs7195958 chr16:72036577 A/G cg16558253 chr16:72132732 DHX38 0.38 5.44 0.32 1.2e-7 Prostate cancer; CESC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg04025307 chr7:1156635 C7orf50 0.58 9.93 0.52 5.64e-20 Longevity;Endometriosis; CESC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg26855724 chr1:75198818 TYW3;CRYZ 0.52 6.57 0.37 2.7e-10 Resistin levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06089844 chr16:68344779 PRMT7;SLC7A6OS -0.5 -6.2 -0.36 2.14e-9 Ulcerative colitis; CESC cis rs59698941 0.709 rs12163973 chr5:132226664 G/A cg02081065 chr5:132209139 LEAP2 -0.52 -5.11 -0.3 6.08e-7 Apolipoprotein A-IV levels; CESC cis rs80282103 0.618 rs10794720 chr10:1156165 A/G cg08668510 chr10:1095578 IDI1 -0.67 -6.0 -0.35 6.46e-9 Glomerular filtration rate (creatinine); CESC cis rs826838 0.935 rs7301104 chr12:39182821 C/T cg26384229 chr12:38710491 ALG10B 0.78 13.13 0.63 1.09e-30 Heart rate; CESC cis rs3749237 0.555 rs2117939 chr3:49415179 C/A cg03060546 chr3:49711283 APEH 0.75 11.32 0.57 1.68e-24 Resting heart rate; CESC cis rs6032067 0.929 rs17425504 chr20:43880089 T/C cg10761708 chr20:43804764 PI3 0.49 5.92 0.34 1.01e-8 Blood protein levels; CESC cis rs921968 0.608 rs832817 chr2:219358603 C/T cg02176678 chr2:219576539 TTLL4 0.43 7.54 0.42 7.27e-13 Mean corpuscular hemoglobin concentration; CESC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.61 0.33 5.1e-8 Tonsillectomy; CESC cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg07507251 chr3:52567010 NT5DC2 0.4 6.98 0.39 2.43e-11 Bipolar disorder; CESC cis rs10206020 0.885 rs6720797 chr2:1574340 T/C cg26248373 chr2:1572462 NA -0.59 -6.93 -0.39 3.22e-11 IgG glycosylation; CESC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg21951975 chr1:209979733 IRF6 0.61 9.29 0.5 6.01e-18 Cleft lip with or without cleft palate; CESC trans rs875971 0.660 rs28698552 chr7:66005018 A/G cg26939375 chr7:64535504 NA 0.64 8.73 0.47 2.85e-16 Aortic root size; CESC cis rs7474896 0.507 rs2474555 chr10:38465220 G/C cg25427524 chr10:38739819 LOC399744 -0.52 -5.13 -0.3 5.51e-7 Obesity (extreme); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14187204 chr20:18269147 ZNF133 0.58 6.22 0.36 1.95e-9 Gut microbiome composition (summer); CESC cis rs2731664 0.792 rs335420 chr5:176898619 C/T cg23176889 chr5:176863531 GRK6 0.64 11.78 0.59 4.81e-26 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs13115356 chr4:98933171 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs11640533 0.901 rs11862250 chr16:53415038 C/A cg27158636 chr16:53407423 NA 0.43 5.73 0.33 2.67e-8 Intelligence (multi-trait analysis); CESC cis rs1048238 0.506 rs6668183 chr1:16173814 G/C cg21385522 chr1:16154831 NA 0.44 5.73 0.33 2.72e-8 Systolic blood pressure; CESC cis rs6484504 0.625 rs7940420 chr11:31366700 T/A cg14844989 chr11:31128820 NA 0.39 5.31 0.31 2.29e-7 Red blood cell count; CESC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg23034840 chr1:205782522 SLC41A1 0.6 6.84 0.39 5.58e-11 Menarche (age at onset); CESC cis rs2197308 0.667 rs11181073 chr12:37898543 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.63 0.33 4.66e-8 Morning vs. evening chronotype; CESC trans rs3942852 0.594 rs10769311 chr11:48094009 T/C cg15704280 chr7:45808275 SEPT13 -0.73 -9.53 -0.51 1.06e-18 Acute lymphoblastic leukemia (childhood); CESC trans rs78579285 0.544 rs11549835 chr16:88781073 G/A cg15076811 chr1:11001038 NA 0.7 6.01 0.35 6.14e-9 Joint mobility (Beighton score); CESC cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg10556349 chr10:835070 NA 0.53 5.2 0.3 3.93e-7 Eosinophil percentage of granulocytes; CESC cis rs4474465 0.850 rs10793330 chr11:78269985 T/C cg27205649 chr11:78285834 NARS2 0.44 5.69 0.33 3.28e-8 Alzheimer's disease (survival time); CESC cis rs7772486 0.846 rs9373482 chr6:146363123 A/C cg05347473 chr6:146136440 FBXO30 0.5 6.5 0.37 3.88e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs12130219 0.500 rs4845743 chr1:152184149 A/G cg25272121 chr1:152190972 HRNR -0.38 -5.82 -0.34 1.69e-8 Inflammatory skin disease; CESC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg02574844 chr11:5959923 NA -0.43 -5.15 -0.3 5.03e-7 DNA methylation (variation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16593646 chr5:71616216 PTCD2;MRPS27 0.57 6.75 0.38 9.43e-11 Gut microbiome composition (summer); CESC cis rs1538970 0.962 rs4660849 chr1:45819872 A/G cg05343316 chr1:45956843 TESK2 -0.82 -11.17 -0.57 5.6e-24 Platelet count; CESC cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.46 6.05 0.35 5.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17197538 chr12:25404353 KRAS -0.6 -6.98 -0.39 2.44e-11 Gut microbiome composition (summer); CESC cis rs78456975 1.000 rs11903168 chr2:1560497 C/G cg26248373 chr2:1572462 NA -0.59 -5.7 -0.33 3.11e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg18337363 chr3:52569053 NT5DC2 0.29 5.03 0.3 8.89e-7 Bipolar disorder; CESC cis rs6669072 0.967 rs12130887 chr1:91240696 G/T cg08895590 chr1:91227319 NA -0.31 -5.04 -0.3 8.43e-7 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13467950 chr10:74033549 DDIT4 0.64 7.4 0.41 1.82e-12 Gut microbiome composition (summer); CESC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg18876405 chr7:65276391 NA 0.69 9.6 0.51 6.27e-19 Aortic root size; CESC cis rs6964587 0.836 rs757040 chr7:91552016 A/G cg17063962 chr7:91808500 NA -0.49 -5.69 -0.33 3.34e-8 Breast cancer; CESC cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.52 5.79 0.33 2.02e-8 Osteoporosis; CESC cis rs9660992 0.710 rs1668869 chr1:205239779 G/C cg00857998 chr1:205179979 DSTYK 0.47 5.35 0.31 1.87e-7 Mean corpuscular volume;Mean platelet volume; CESC trans rs11098499 0.863 rs6835635 chr4:120458867 A/G cg25214090 chr10:38739885 LOC399744 0.67 9.18 0.49 1.28e-17 Corneal astigmatism; CESC cis rs12681288 0.676 rs7459467 chr8:999359 C/T cg15309053 chr8:964076 NA 0.41 6.92 0.39 3.44e-11 Schizophrenia; CESC cis rs116095464 0.558 rs9687898 chr5:253952 A/G cg22857025 chr5:266934 NA -1.29 -18.21 -0.75 1.29e-48 Breast cancer; CESC cis rs34779708 0.966 rs4934537 chr10:35441512 C/T cg03585969 chr10:35415529 CREM 0.76 10.0 0.52 3.56e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6893300 0.785 rs11738720 chr5:179154998 A/G cg14593053 chr5:179126677 CANX -0.47 -5.19 -0.3 4.12e-7 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09964670 chr19:5720572 TMEM146;LONP1 0.62 7.38 0.41 2.11e-12 Gut microbiome composition (summer); CESC cis rs2629540 0.889 rs7090422 chr10:126439361 T/A cg08799069 chr10:126477246 METTL10 -0.67 -9.16 -0.49 1.44e-17 Cocaine dependence; CESC cis rs9549260 0.755 rs17061450 chr13:41183716 G/A cg21288729 chr13:41239152 FOXO1 0.61 7.66 0.43 3.49e-13 Red blood cell count; CESC cis rs1707322 0.721 rs4559551 chr1:46167533 T/C cg03146154 chr1:46216737 IPP 0.81 11.37 0.57 1.12e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6502050 1.000 rs6502050 chr17:80058236 C/G cg23985595 chr17:80112537 CCDC57 0.4 6.14 0.35 3.01e-9 Life satisfaction; CESC cis rs2228479 0.850 rs62056063 chr16:89903680 C/T cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs2180341 1.000 rs9401950 chr6:127655485 C/T cg24812749 chr6:127587940 RNF146 1.07 15.4 0.69 1.16e-38 Breast cancer; CESC cis rs2243480 0.831 rs7806717 chr7:65393174 A/G cg12463550 chr7:65579703 CRCP -0.7 -5.58 -0.32 5.87e-8 Diabetic kidney disease; CESC cis rs1003719 0.715 rs8130643 chr21:38551715 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.13 -0.45 1.66e-14 Eye color traits; CESC cis rs722599 0.715 rs11851433 chr14:75339450 C/T cg11812906 chr14:75593930 NEK9 0.48 6.09 0.35 4.02e-9 IgG glycosylation; CESC cis rs2243480 1.000 rs35391607 chr7:65360829 G/A cg12463550 chr7:65579703 CRCP 0.69 5.62 0.33 4.79e-8 Diabetic kidney disease; CESC cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg10018233 chr7:150070692 REPIN1 -0.45 -7.22 -0.41 5.47e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs875971 0.577 rs34888281 chr7:65585771 C/T cg11764359 chr7:65958608 NA -0.61 -7.55 -0.42 6.85e-13 Aortic root size; CESC cis rs854765 0.663 rs3744115 chr17:17749822 G/A cg04398451 chr17:18023971 MYO15A 0.64 9.16 0.49 1.44e-17 Total body bone mineral density; CESC cis rs791888 1.000 rs791888 chr10:89412575 G/T cg13926569 chr10:89418898 PAPSS2 -0.43 -6.18 -0.35 2.45e-9 Magnesium levels; CESC cis rs634534 0.562 rs661335 chr11:65754061 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.53 0.37 3.42e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs909674 0.515 rs9611170 chr22:39784845 G/C cg02038168 chr22:39784481 NA -0.67 -8.63 -0.47 5.82e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs2243480 1.000 rs402418 chr7:65509469 G/A cg12463550 chr7:65579703 CRCP 0.69 5.37 0.31 1.74e-7 Diabetic kidney disease; CESC cis rs7178572 0.889 rs59153558 chr15:77806770 A/G cg22256960 chr15:77711686 NA -0.55 -7.0 -0.4 2.06e-11 Type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25061763 chr12:62860430 MON2 -0.47 -6.02 -0.35 5.95e-9 Ulcerative colitis; CESC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg03709012 chr19:19516395 GATAD2A -0.96 -14.42 -0.66 3.32e-35 Tonsillectomy; CESC cis rs3204270 0.684 rs57405099 chr17:79637065 T/C cg26965718 chr17:79658957 HGS -0.73 -5.42 -0.32 1.31e-7 Dental caries; CESC cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg26597838 chr10:835615 NA 1.16 11.43 0.57 7.45e-25 Eosinophil percentage of granulocytes; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg05923103 chr1:51701583 RNF11 -0.56 -6.27 -0.36 1.5e-9 Subjective well-being; CESC cis rs73001065 0.636 rs28720066 chr19:19572220 G/T cg03709012 chr19:19516395 GATAD2A 1.01 7.85 0.43 1.01e-13 LDL cholesterol; CESC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg20203395 chr5:56204925 C5orf35 0.39 5.06 0.3 7.69e-7 Initial pursuit acceleration; CESC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg24101359 chr6:42928495 GNMT 0.55 7.88 0.44 8.37e-14 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1008375 0.966 rs3775927 chr4:17599894 G/T cg16339924 chr4:17578868 LAP3 0.65 8.26 0.45 6.87e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1843834 0.539 rs10177898 chr2:225437552 C/T cg22509189 chr2:225307070 NA -0.41 -5.46 -0.32 1.1e-7 IgE levels in asthmatics (D.p. specific); CESC cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg05347473 chr6:146136440 FBXO30 0.51 6.65 0.38 1.69e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2014572 0.967 rs10418480 chr19:57755055 C/T cg24459738 chr19:57751996 ZNF805 -0.55 -7.82 -0.43 1.23e-13 Hyperactive-impulsive symptoms; CESC cis rs9549367 0.713 rs3024744 chr13:113821477 A/C cg00898013 chr13:113819073 PROZ -0.51 -7.17 -0.4 7.7e-12 Platelet distribution width; CESC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.7 -0.33 3.21e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs9487051 0.676 rs6903107 chr6:109597711 A/G cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg15369054 chr17:80825471 TBCD 0.5 6.89 0.39 4.09e-11 Breast cancer; CESC cis rs12325245 0.536 rs17821543 chr16:58540875 C/T cg01152986 chr16:58549298 SETD6 0.87 5.83 0.34 1.64e-8 Schizophrenia; CESC cis rs1059312 0.932 rs4760592 chr12:129287149 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.7 -9.54 -0.51 9.53e-19 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16449816 chr17:55927528 MRPS23 0.57 6.59 0.38 2.38e-10 Gut microbiome composition (summer); CESC cis rs7084402 0.935 rs1632584 chr10:60282078 T/C cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.81e-18 Refractive error; CESC cis rs1405069 0.809 rs1046279 chr6:36932571 C/T cg26433444 chr6:36932349 PI16 -0.41 -7.84 -0.43 1.08e-13 Chemerin levels; CESC cis rs853679 0.546 rs13214023 chr6:28332141 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL -0.64 -5.05 -0.3 8.16e-7 Depression; CESC cis rs6570726 0.935 rs407721 chr6:145871354 A/C cg05347473 chr6:146136440 FBXO30 0.48 6.49 0.37 4.11e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03535439 chr6:42981950 MEA1;KLHDC3 0.54 6.15 0.35 2.91e-9 Gut microbiome composition (summer); CESC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg08632164 chr7:65971372 NA 0.31 5.11 0.3 6.27e-7 Aortic root size; CESC cis rs7824557 0.737 rs2293855 chr8:11177410 G/A cg21775007 chr8:11205619 TDH 0.48 6.97 0.39 2.48e-11 Retinal vascular caliber; CESC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg09165964 chr15:75287851 SCAMP5 0.49 6.43 0.37 6.03e-10 Breast cancer; CESC cis rs10924309 0.855 rs7413150 chr1:245858729 G/A cg00036263 chr1:245852353 KIF26B -0.41 -5.2 -0.3 3.9e-7 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs1153858 1.000 rs2467863 chr15:45641880 G/A cg21132104 chr15:45694354 SPATA5L1 0.85 11.46 0.58 5.76e-25 Homoarginine levels; CESC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -9.68 -0.51 3.58e-19 Extrinsic epigenetic age acceleration; CESC cis rs8133932 0.654 rs382303 chr21:47349284 G/A cg14185626 chr21:47401492 COL6A1 -0.48 -5.36 -0.31 1.78e-7 Schizophrenia; CESC cis rs714031 0.934 rs9607667 chr22:40077488 C/T cg21377881 chr22:40064566 CACNA1I -0.36 -5.81 -0.34 1.81e-8 Schizophrenia; CESC cis rs1005277 0.505 rs719569 chr10:38154415 T/G cg00409905 chr10:38381863 ZNF37A 0.56 7.73 0.43 2.28e-13 Extrinsic epigenetic age acceleration; CESC cis rs10129255 0.500 rs2105989 chr14:107138216 C/T cg07470598 chr14:107239068 NA 0.38 5.4 0.31 1.5e-7 Kawasaki disease; CESC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg03188948 chr7:1209495 NA 0.72 6.93 0.39 3.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg22143856 chr6:28129313 ZNF389 0.45 5.48 0.32 9.7e-8 Parkinson's disease; CESC cis rs1538970 0.961 rs7543428 chr1:45839643 A/G cg03146154 chr1:46216737 IPP 0.45 5.49 0.32 9.43e-8 Platelet count; CESC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg06636001 chr8:8085503 FLJ10661 0.41 5.08 0.3 7.26e-7 Mood instability; CESC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.51 0.37 3.77e-10 Bipolar disorder; CESC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg19163074 chr7:65112434 INTS4L2 -0.43 -5.34 -0.31 2e-7 Aortic root size; CESC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg05564831 chr3:52568323 NT5DC2 0.46 6.96 0.39 2.72e-11 Bipolar disorder; CESC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.91 -0.56 3.8e-23 Alzheimer's disease; CESC cis rs62229266 0.804 rs2835263 chr21:37430245 A/G cg12218747 chr21:37451666 NA 0.39 5.53 0.32 7.61e-8 Mitral valve prolapse; CESC cis rs2070488 0.930 rs928813 chr3:38528537 G/T cg24069376 chr3:38537580 EXOG 0.49 8.96 0.48 5.98e-17 Electrocardiographic conduction measures; CESC cis rs712039 0.652 rs34711199 chr17:35858039 C/T cg16670864 chr17:35848621 DUSP14 0.45 5.68 0.33 3.6e-8 Tuberculosis; CESC cis rs643506 0.874 rs663511 chr11:111710034 T/C cg17089665 chr11:111648010 NA -0.35 -5.1 -0.3 6.51e-7 Breast cancer; CESC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg18230493 chr5:56204884 C5orf35 -0.59 -7.86 -0.43 9.52e-14 Initial pursuit acceleration; CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 6.92 0.39 3.36e-11 Bipolar disorder; CESC cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg15605315 chr1:45957053 TESK2 0.43 5.48 0.32 1.01e-7 High light scatter reticulocyte count; CESC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg08736216 chr1:53307985 ZYG11A 0.3 5.04 0.3 8.5e-7 Monocyte count; CESC cis rs27434 0.660 rs42398 chr5:96120455 C/T cg16492584 chr5:96139282 ERAP1 -0.49 -5.96 -0.34 8.01e-9 Ankylosing spondylitis; CESC cis rs6723226 0.708 rs2754513 chr2:32782763 G/A cg02381751 chr2:32503542 YIPF4 0.83 12.07 0.6 5.21e-27 Intelligence (multi-trait analysis); CESC cis rs2180341 1.000 rs7776136 chr6:127638348 A/T cg27446573 chr6:127587934 RNF146 1.11 16.48 0.71 1.76e-42 Breast cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19901472 chr1:29557379 MECR -0.47 -6.07 -0.35 4.38e-9 Asthma; CESC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg03609598 chr5:56110824 MAP3K1 -0.52 -5.57 -0.32 6.2e-8 Initial pursuit acceleration; CESC cis rs12142240 0.698 rs41294456 chr1:46809782 T/C cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs728616 0.558 rs34268041 chr10:82148639 A/G cg05935833 chr10:81318306 SFTPA2 -0.44 -5.58 -0.32 5.92e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs763121 0.853 rs5750626 chr22:38977890 G/C cg06544989 chr22:39130855 UNC84B 0.5 8.26 0.45 6.86e-15 Menopause (age at onset); CESC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg12463550 chr7:65579703 CRCP -0.5 -6.42 -0.37 6.11e-10 Aortic root size; CESC cis rs7171869 1 rs7171869 chr15:78900909 A/G cg24631222 chr15:78858424 CHRNA5 -0.81 -9.95 -0.52 4.93e-20 Post bronchodilator FEV1; CESC cis rs1707322 0.827 rs10890347 chr1:46242332 A/T cg06784218 chr1:46089804 CCDC17 -0.39 -6.58 -0.37 2.53e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19973604 chr17:73914282 FBF1 -0.56 -6.56 -0.37 2.87e-10 Gut microbiome composition (summer); CESC cis rs727505 0.520 rs1454125 chr7:124862733 C/T cg23710748 chr7:124431027 NA -0.34 -5.17 -0.3 4.59e-7 Lewy body disease; CESC cis rs4737010 0.511 rs7006871 chr8:41670952 A/G cg08923054 chr8:41654455 ANK1 0.53 6.83 0.39 5.64e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs6499129 0.558 rs16957489 chr16:67651879 G/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.44 -0.37 5.61e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4595586 0.525 rs4441057 chr12:39420620 T/A cg13010199 chr12:38710504 ALG10B 0.43 5.25 0.31 3.17e-7 Morning vs. evening chronotype; CESC cis rs7524258 0.778 rs12028181 chr1:7315085 C/T cg07173049 chr1:7289937 CAMTA1 -0.33 -5.11 -0.3 6.13e-7 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs9916302 0.904 rs6503519 chr17:37706578 A/G cg20243544 chr17:37824526 PNMT 0.53 6.63 0.38 1.87e-10 Glomerular filtration rate (creatinine); CESC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg23281280 chr6:28129359 ZNF389 0.59 8.07 0.44 2.52e-14 Depression; CESC cis rs7020830 0.931 rs7027473 chr9:37132462 A/G cg14294708 chr9:37120828 ZCCHC7 1.27 25.81 0.85 2.72e-74 Schizophrenia; CESC cis rs12497850 0.863 rs4974084 chr3:48939080 G/A cg02487422 chr3:49467188 NICN1 0.41 5.28 0.31 2.68e-7 Parkinson's disease; CESC cis rs4233802 1.000 rs4425094 chr2:151139891 C/T cg25300694 chr2:151184358 NA 0.88 7.6 0.42 5.07e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg16325326 chr1:53192061 ZYG11B 0.8 12.22 0.6 1.6e-27 Monocyte count; CESC cis rs17401966 1.000 rs2275424 chr1:10356562 C/A cg15208524 chr1:10270712 KIF1B 0.51 6.57 0.37 2.66e-10 Hepatocellular carcinoma; CESC cis rs4664308 0.840 rs17218566 chr2:161054748 C/T cg03641300 chr2:160917029 PLA2R1 -0.65 -9.56 -0.51 8.34e-19 Idiopathic membranous nephropathy; CESC cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg26769984 chr7:1090371 C7orf50 0.65 7.37 0.41 2.24e-12 Bronchopulmonary dysplasia; CESC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.69 0.38 1.3100000000000001e-10 Prudent dietary pattern; CESC cis rs4919087 0.715 rs2484880 chr10:98998355 T/C cg25902810 chr10:99078978 FRAT1 -0.46 -5.2 -0.3 4.03e-7 Monocyte count; CESC cis rs1670533 1.000 rs4690215 chr4:1054619 G/C cg27284194 chr4:1044797 NA 0.46 5.85 0.34 1.42e-8 Recombination rate (females); CESC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg01988459 chr11:68622903 NA -0.41 -5.34 -0.31 2.04e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6964587 1.000 rs10225892 chr7:91671020 A/G cg17063962 chr7:91808500 NA 0.55 7.49 0.42 1.06e-12 Breast cancer; CESC cis rs6493487 0.512 rs17521919 chr15:51291056 A/C cg02338191 chr15:51200825 AP4E1 0.6 5.5 0.32 8.84e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs561341 1.000 rs535151 chr17:30317405 C/T cg12193833 chr17:30244370 NA -0.52 -5.95 -0.34 8.43e-9 Hip circumference adjusted for BMI; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08537418 chr17:5342414 C1QBP -0.45 -6.17 -0.35 2.53e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg25036284 chr2:26402008 FAM59B -0.9 -10.54 -0.54 6.54e-22 Gut microbiome composition (summer); CESC cis rs6754311 0.681 rs4954493 chr2:136609975 T/C cg07169764 chr2:136633963 MCM6 -0.69 -8.48 -0.46 1.59e-15 Mosquito bite size; CESC cis rs9815354 0.812 rs17217536 chr3:41923300 A/C cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.93e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg25767906 chr1:53392781 SCP2 0.53 7.67 0.43 3.35e-13 Monocyte count; CESC cis rs514406 0.893 rs1242317 chr1:53414766 T/C cg08736216 chr1:53307985 ZYG11A -0.41 -6.53 -0.37 3.31e-10 Monocyte count; CESC cis rs7044106 0.734 rs10491784 chr9:123432289 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.83 0.34 1.58e-8 Hip circumference adjusted for BMI; CESC trans rs11039798 0.512 rs28453037 chr11:49006929 C/A cg15704280 chr7:45808275 SEPT13 0.64 6.78 0.38 7.72e-11 Axial length; CESC cis rs4253772 0.530 rs9627387 chr22:46684678 A/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.6 6.52 0.37 3.62e-10 LDL cholesterol;Cholesterol, total; CESC cis rs8002861 0.875 rs12872943 chr13:44410553 G/A cg19180546 chr13:44453867 C13orf31;CCDC122 -0.4 -5.08 -0.3 7.11e-7 Leprosy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25998860 chr5:126853954 PRRC1 -0.46 -6.82 -0.39 6.26e-11 Gambling; CESC cis rs11098499 0.618 rs35265692 chr4:120325135 T/C cg24375607 chr4:120327624 NA 0.48 5.89 0.34 1.15e-8 Corneal astigmatism; CESC cis rs2797160 1.000 rs1777226 chr6:126017691 C/A cg05901451 chr6:126070800 HEY2 0.46 6.48 0.37 4.56e-10 Endometrial cancer; CESC cis rs7223966 0.618 rs9906903 chr17:61634508 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.46 5.03 0.3 9.16e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs3741151 0.773 rs73542952 chr11:73108556 A/G cg17517138 chr11:73019481 ARHGEF17 0.98 7.14 0.4 8.86e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs61931739 0.500 rs11053218 chr12:34474792 A/C cg19457237 chr12:34500585 NA 0.38 5.2 0.3 3.93e-7 Morning vs. evening chronotype; CESC cis rs8060686 0.641 rs112099181 chr16:68154230 T/C cg26727032 chr16:67993705 SLC12A4 -0.51 -6.26 -0.36 1.59e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21582582 chr3:182698605 DCUN1D1 -0.44 -6.01 -0.35 6.2e-9 Intelligence (multi-trait analysis); CESC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.83 8.82 0.48 1.58e-16 Platelet count; CESC cis rs9790314 0.905 rs7632797 chr3:161002694 C/T cg03342759 chr3:160939853 NMD3 0.43 5.89 0.34 1.15e-8 Morning vs. evening chronotype; CESC cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg16339924 chr4:17578868 LAP3 0.66 8.49 0.46 1.48e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4148883 0.737 rs13148577 chr4:100060836 G/A cg13256891 chr4:100009986 ADH5 0.56 7.34 0.41 2.64e-12 Alcohol dependence; CESC cis rs8017423 0.967 rs1959002 chr14:90670994 T/A cg14092571 chr14:90743983 NA -0.55 -8.18 -0.45 1.2e-14 Mortality in heart failure; CESC cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg07148914 chr20:33460835 GGT7 -0.44 -5.59 -0.32 5.75e-8 Height; CESC cis rs3096299 0.748 rs3102339 chr16:89442711 C/T cg02187348 chr16:89574699 SPG7 0.57 7.41 0.41 1.74e-12 Multiple myeloma (IgH translocation); CESC cis rs6866344 0.697 rs61247551 chr5:178133503 G/A cg10224037 chr5:178157518 ZNF354A 0.67 7.34 0.41 2.64e-12 Neutrophil percentage of white cells; CESC cis rs2929278 0.589 rs11638972 chr15:44074691 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.47 -7.26 -0.41 4.23e-12 Schizophrenia; CESC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 7.4 0.41 1.78e-12 Melanoma; CESC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg06028605 chr16:24865363 SLC5A11 0.53 7.72 0.43 2.45e-13 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10423910 chr5:127420075 SLC12A2;FLJ33630 0.5 6.3 0.36 1.26e-9 Gut microbiota (bacterial taxa); CESC cis rs6429082 0.875 rs4659524 chr1:235583354 C/T cg26050004 chr1:235667680 B3GALNT2 -0.4 -5.32 -0.31 2.21e-7 Adiposity; CESC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 12.51 0.61 1.61e-28 Alzheimer's disease; CESC cis rs6815814 0.851 rs17582921 chr4:38892649 T/C cg02016764 chr4:38805732 TLR1 -0.57 -6.45 -0.37 5.26e-10 Breast cancer; CESC cis rs12477438 0.748 rs10200974 chr2:99675227 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -8.54 -0.46 1.04e-15 Chronic sinus infection; CESC trans rs7615952 0.599 rs66532274 chr3:125731845 G/A cg07211511 chr3:129823064 LOC729375 -0.59 -7.07 -0.4 1.37e-11 Blood pressure (smoking interaction); CESC cis rs72720396 0.789 rs10922910 chr1:91199862 G/T cg13456504 chr1:91191583 NA 0.49 7.07 0.4 1.38e-11 Morning vs. evening chronotype;Chronotype; CESC cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg05234568 chr11:5960015 NA -0.64 -7.62 -0.42 4.55e-13 DNA methylation (variation); CESC cis rs2370759 1.000 rs7910776 chr10:32639093 C/T cg01819863 chr10:32635814 EPC1 1.1 10.93 0.56 3.25e-23 Sexual dysfunction (female); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19334895 chr19:18942619 UPF1 0.52 6.25 0.36 1.59e-9 Gut microbiome composition (summer); CESC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg05368731 chr17:41323189 NBR1 0.71 8.26 0.45 7.18e-15 Menopause (age at onset); CESC cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg14416269 chr4:6271139 WFS1 0.46 7.71 0.43 2.49e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg22105103 chr4:187893119 NA 0.49 6.86 0.39 4.89e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6540559 0.673 rs7525951 chr1:210018306 C/T cg23283495 chr1:209979779 IRF6 -0.48 -5.53 -0.32 7.61e-8 Cleft lip with or without cleft palate; CESC cis rs9300255 0.602 rs6488864 chr12:123618362 G/C cg00376283 chr12:123451042 ABCB9 0.62 6.66 0.38 1.57e-10 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22918356 chr10:134496823 INPP5A -0.68 -8.18 -0.45 1.22e-14 Gut microbiome composition (summer); CESC cis rs6835098 1.000 rs6814857 chr4:174082805 T/A cg08422745 chr4:174089978 GALNT7 -0.73 -9.49 -0.5 1.37e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs11098499 0.754 rs1980027 chr4:120251577 C/T cg09307838 chr4:120376055 NA 0.77 10.45 0.54 1.22e-21 Corneal astigmatism; CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg04025307 chr7:1156635 C7orf50 0.41 5.56 0.32 6.68e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17376456 0.825 rs10061377 chr5:93174513 T/C cg25358565 chr5:93447407 FAM172A 1.1 10.64 0.55 3.1e-22 Diabetic retinopathy; CESC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg17971929 chr21:40555470 PSMG1 1.05 16.48 0.71 1.75e-42 Cognitive function; CESC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg23758822 chr17:41437982 NA 0.79 11.1 0.56 9.08e-24 Menopause (age at onset); CESC cis rs447735 0.587 rs7188458 chr16:89726484 A/G cg04240660 chr16:89714849 CHMP1A -0.36 -5.13 -0.3 5.66e-7 Hemoglobin concentration; CESC cis rs7178909 0.872 rs10852124 chr15:90430464 C/T cg19708238 chr15:90437601 AP3S2 0.4 5.68 0.33 3.54e-8 Common traits (Other); CESC cis rs15676 0.733 rs2900269 chr9:131569878 G/T cg00228799 chr9:131580591 ENDOG 0.5 6.0 0.35 6.44e-9 Blood metabolite levels; CESC cis rs793571 0.669 rs714696 chr15:58962987 C/G cg05156742 chr15:59063176 FAM63B 0.63 8.22 0.45 9.3e-15 Schizophrenia; CESC cis rs2637266 0.967 rs2579748 chr10:78328313 T/C cg18941641 chr10:78392320 NA 0.41 7.65 0.43 3.68e-13 Pulmonary function; CESC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg16325326 chr1:53192061 ZYG11B -1.0 -17.64 -0.73 1.36e-46 Monocyte count; CESC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg09359103 chr1:154839909 KCNN3 -0.65 -11.99 -0.59 9.49e-27 Prostate cancer; CESC cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg19482086 chr6:160211437 TCP1;MRPL18 0.63 7.63 0.42 4.18e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs2439831 1.000 rs2251538 chr15:43767209 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.48 0.54 9.91e-22 Lung cancer in ever smokers; CESC cis rs5769707 0.732 rs135865 chr22:50004829 G/A cg20744362 chr22:50050164 C22orf34 0.45 7.43 0.42 1.5e-12 Monocyte count;Monocyte percentage of white cells; CESC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.08 -13.27 -0.63 3.74e-31 Gut microbiome composition (summer); CESC cis rs2658782 0.826 rs2925355 chr11:93090887 T/C cg15737290 chr11:93063684 CCDC67 0.59 7.43 0.42 1.52e-12 Pulmonary function decline; CESC trans rs6535028 1.000 rs4241953 chr4:135460904 G/C cg04198210 chr15:74528606 CCDC33 -0.6 -6.01 -0.35 6.2e-9 Response to radiotherapy in prostate cancer (overall toxicity); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13180005 chr1:182360683 GLUL 0.59 6.58 0.37 2.47e-10 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.82e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9868809 0.881 rs9878063 chr3:48678971 T/G cg07636037 chr3:49044803 WDR6 -0.6 -5.17 -0.3 4.73e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs916888 0.821 rs199506 chr17:44859031 A/G cg01570182 chr17:44337453 NA -0.88 -10.55 -0.54 5.83e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10465746 0.747 rs1952066 chr1:84436456 T/C cg10977910 chr1:84465055 TTLL7 0.52 7.13 0.4 9.46e-12 Obesity-related traits; CESC cis rs1395 0.710 rs11682913 chr2:27473649 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 5.64 0.33 4.38e-8 Blood metabolite levels; CESC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg15595755 chr5:1867978 NA 0.5 8.03 0.44 3.24e-14 Cardiovascular disease risk factors; CESC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.45 -0.5 1.94e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs644799 0.965 rs1944080 chr11:95503636 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.94 14.93 0.68 5.42e-37 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2637266 0.561 rs10824440 chr10:78489079 C/T cg18941641 chr10:78392320 NA -0.33 -5.31 -0.31 2.31e-7 Pulmonary function; CESC cis rs3747547 1.000 rs7028246 chr9:37917602 A/G cg13774184 chr9:37916125 SHB -0.63 -5.83 -0.34 1.63e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs7937682 0.889 rs1784785 chr11:111483306 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.11 0.35 3.49e-9 Primary sclerosing cholangitis; CESC cis rs6460942 0.597 rs12699388 chr7:12536336 T/C cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC cis rs9309473 0.519 rs12618600 chr2:73890682 T/C cg20560298 chr2:73613845 ALMS1 0.51 7.15 0.4 8.44e-12 Metabolite levels; CESC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg07507251 chr3:52567010 NT5DC2 0.4 7.06 0.4 1.49e-11 Bipolar disorder; CESC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg18099408 chr3:52552593 STAB1 -0.3 -5.04 -0.3 8.71e-7 Bipolar disorder; CESC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg24562669 chr7:97807699 LMTK2 0.52 7.57 0.42 6.02e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs7520050 0.778 rs3014216 chr1:46035760 A/T cg06784218 chr1:46089804 CCDC17 0.33 5.99 0.35 6.85e-9 Red blood cell count;Reticulocyte count; CESC cis rs9787249 0.915 rs6664570 chr1:40206298 G/A cg19912559 chr1:40204330 PPIE 0.43 6.61 0.38 2.14e-10 Blood protein levels; CESC cis rs8062405 0.755 rs7193402 chr16:28586127 A/G cg01378222 chr16:28622494 SULT1A1 0.31 5.19 0.3 4.09e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg12560992 chr17:57184187 TRIM37 -0.93 -15.47 -0.69 6.8e-39 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01032946 chr16:30991033 SETD1A -0.58 -6.04 -0.35 5.24e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.03 -0.49 3.55e-17 Developmental language disorder (linguistic errors); CESC cis rs2644899 0.859 rs2604893 chr19:41293543 A/G cg24958765 chr19:41283667 RAB4B -0.57 -6.36 -0.36 8.61e-10 Post bronchodilator FEV1/FVC ratio; CESC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.44 6.23 0.36 1.86e-9 Menopause (age at onset); CESC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg19592336 chr6:28129416 ZNF389 -0.54 -7.01 -0.4 1.92e-11 Parkinson's disease; CESC cis rs60154123 0.505 rs2206043 chr1:210042983 G/A cg21951975 chr1:209979733 IRF6 0.59 6.87 0.39 4.47e-11 Coronary artery disease; CESC cis rs11690935 0.531 rs62183800 chr2:172867273 C/T cg13550731 chr2:172543902 DYNC1I2 0.49 6.75 0.38 9.18e-11 Schizophrenia; CESC cis rs75557865 1 rs75557865 chr3:121652141 G/A cg20356878 chr3:121714668 ILDR1 0.45 6.57 0.37 2.71e-10 Allergic disease (asthma, hay fever or eczema); CESC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg18876405 chr7:65276391 NA -0.47 -6.29 -0.36 1.31e-9 Calcium levels; CESC cis rs66573146 1.000 rs55672215 chr4:6970529 T/C cg00086871 chr4:6988644 TBC1D14 1.14 7.26 0.41 4.33e-12 Granulocyte percentage of myeloid white cells; CESC cis rs11051970 0.592 rs7132235 chr12:32536303 T/A cg24626660 chr12:32551988 NA 0.39 5.26 0.31 2.95e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9300255 0.596 rs11057202 chr12:123720775 G/T cg05973401 chr12:123451056 ABCB9 0.46 5.56 0.32 6.62e-8 Neutrophil percentage of white cells; CESC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC cis rs2249625 0.935 rs1852702 chr6:72908366 T/C cg18830697 chr6:72922368 RIMS1 -0.42 -5.81 -0.34 1.78e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs2933343 0.729 rs1680786 chr3:128644840 T/C cg24203234 chr3:128598194 ACAD9 0.43 5.8 0.34 1.93e-8 IgG glycosylation; CESC cis rs9914544 0.689 rs11078421 chr17:18804385 A/G cg26378065 chr17:18585709 ZNF286B 0.43 5.85 0.34 1.41e-8 Educational attainment (years of education); CESC cis rs6963495 0.818 rs115609508 chr7:105163716 C/A cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs11645898 0.748 rs56387295 chr16:72055336 C/A cg14768367 chr16:72042858 DHODH -0.83 -6.78 -0.38 7.88e-11 Blood protein levels; CESC cis rs2380220 0.606 rs4571572 chr6:96004823 T/C cg15832292 chr6:96025679 MANEA 0.64 7.3 0.41 3.28e-12 Behavioural disinhibition (generation interaction); CESC cis rs897984 0.542 rs3751855 chr16:31091209 T/C cg00531865 chr16:30841666 NA -0.39 -5.45 -0.32 1.18e-7 Dementia with Lewy bodies; CESC cis rs16866061 1.000 rs72974263 chr2:225447371 C/T cg12698349 chr2:225449008 CUL3 0.72 10.51 0.54 7.77e-22 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs3762637 1.000 rs6790051 chr3:122192846 T/C cg24169773 chr3:122142474 KPNA1 -0.54 -6.33 -0.36 1.04e-9 LDL cholesterol levels; CESC cis rs7542091 0.635 rs7550733 chr1:210044968 G/A cg22029157 chr1:209979665 IRF6 0.5 7.98 0.44 4.32e-14 Monobrow; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02957340 chr14:100070899 CCDC85C 0.61 6.86 0.39 4.76e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23142731 chr12:50899018 DIP2B 0.6 6.62 0.38 1.94e-10 Gut microbiome composition (summer); CESC cis rs72945132 0.882 rs7943547 chr11:70133282 C/A cg00319359 chr11:70116639 PPFIA1 0.78 7.74 0.43 2.13e-13 Coronary artery disease; CESC cis rs4948102 0.691 rs4470984 chr7:56033558 A/G cg09872392 chr7:56161020 PHKG1 -0.46 -7.13 -0.4 9.57e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs11098499 0.863 rs10013305 chr4:120450424 G/A cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.24e-28 Corneal astigmatism; CESC cis rs6496667 0.683 rs1869180 chr15:90895467 T/C cg22089800 chr15:90895588 ZNF774 0.64 8.39 0.46 2.95e-15 Rheumatoid arthritis; CESC cis rs2737618 0.674 rs2249150 chr1:200083654 G/A cg21825944 chr1:200113062 NR5A2 -0.47 -7.26 -0.41 4.42e-12 Uric acid levels; CESC cis rs7086627 0.515 rs4933390 chr10:82213081 A/C cg00277334 chr10:82204260 NA -0.91 -15.78 -0.7 5.2e-40 Post bronchodilator FEV1; CESC cis rs7296418 0.885 rs1790104 chr12:123709409 C/T cg00376283 chr12:123451042 ABCB9 0.67 9.59 0.51 6.84e-19 Platelet count; CESC cis rs5167 0.525 rs10402642 chr19:45453878 G/A cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.58e-10 Blood protein levels; CESC cis rs7100689 0.784 rs4934153 chr10:82191255 T/C cg00277334 chr10:82204260 NA -0.62 -7.58 -0.42 5.88e-13 Post bronchodilator FEV1; CESC cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10858047 0.883 rs761755 chr1:115222434 G/A cg12756093 chr1:115239321 AMPD1 -0.52 -5.23 -0.31 3.44e-7 Autism; CESC cis rs1538970 0.924 rs1007858 chr1:45912005 C/T cg05343316 chr1:45956843 TESK2 0.89 12.04 0.59 6.22e-27 Platelet count; CESC trans rs561341 1.000 rs501957 chr17:30314504 C/T cg20587970 chr11:113659929 NA -1.41 -18.06 -0.74 4.37e-48 Hip circumference adjusted for BMI; CESC cis rs6831352 0.918 rs35784540 chr4:100061692 T/A cg13256891 chr4:100009986 ADH5 -0.76 -8.27 -0.45 6.69e-15 Alcohol dependence; CESC cis rs4849845 0.653 rs3925970 chr2:121018153 C/A cg24070213 chr2:121070622 NA 0.44 6.36 0.36 8.64e-10 Mean platelet volume; CESC cis rs7772486 0.875 rs9373485 chr6:146401429 A/T cg05347473 chr6:146136440 FBXO30 0.49 6.65 0.38 1.63e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs734999 0.588 rs745368 chr1:2524205 C/T cg20673091 chr1:2541236 MMEL1 0.43 6.9 0.39 3.84e-11 Ulcerative colitis; CESC trans rs10174398 0.668 rs11887973 chr2:51242058 A/G cg00888162 chr2:38152302 FAM82A1 -0.64 -6.16 -0.35 2.72e-9 Body mass index; CESC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg06873352 chr17:61820015 STRADA 0.7 12.62 0.61 6.49e-29 Prudent dietary pattern; CESC cis rs1008375 0.900 rs3822235 chr4:17694916 C/T cg02297831 chr4:17616191 MED28 -0.42 -5.21 -0.3 3.75e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2250402 0.510 rs2898984 chr15:40324075 G/C cg01081584 chr15:40268610 EIF2AK4 -0.57 -5.42 -0.32 1.33e-7 Corneal curvature; CESC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg21770322 chr7:97807741 LMTK2 0.55 8.18 0.45 1.17e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.41 0.37 6.53e-10 Bipolar disorder; CESC cis rs9831754 0.756 rs12714468 chr3:78445878 A/T cg06138941 chr3:78371609 NA -0.5 -6.12 -0.35 3.34e-9 Calcium levels; CESC cis rs3733585 0.699 rs6449179 chr4:9969117 G/A cg00071950 chr4:10020882 SLC2A9 -0.69 -11.47 -0.58 5.42e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs863345 0.604 rs12133791 chr1:158506682 C/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.82 -0.39 6.1e-11 Pneumococcal bacteremia; CESC trans rs6794880 0.778 rs75823133 chr3:84424374 T/G cg03554283 chr8:76319451 NA 0.57 6.07 0.35 4.44e-9 Body mass index (joint analysis main effects and smoking interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg22143856 chr6:28129313 ZNF389 0.52 6.53 0.37 3.27e-10 Depression; CESC cis rs9910055 0.529 rs228757 chr17:42164885 G/C cg13607699 chr17:42295918 UBTF -0.45 -5.69 -0.33 3.39e-8 Total body bone mineral density; CESC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg24060327 chr5:131705240 SLC22A5 -0.74 -10.25 -0.53 5.64e-21 Breast cancer; CESC trans rs1545843 0.593 rs4761082 chr12:84792755 T/G cg03015433 chr16:56623111 MT3 -0.34 -6.12 -0.35 3.37e-9 Major depressive disorder; CESC trans rs4843747 0.697 rs72818533 chr16:88073841 G/A cg26811252 chr16:29126840 RRN3P2 0.7 9.74 0.51 2.28e-19 Menopause (age at onset); CESC trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg06636001 chr8:8085503 FLJ10661 0.52 6.54 0.37 3.07e-10 Triglycerides; CESC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs2425143 1.000 rs11699690 chr20:34271774 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.16 0.3 4.75e-7 Blood protein levels; CESC cis rs6964587 0.869 rs10242792 chr7:91492103 A/C cg17063962 chr7:91808500 NA 0.49 6.52 0.37 3.47e-10 Breast cancer; CESC cis rs34779708 0.733 rs61449529 chr10:35543914 T/C cg04310649 chr10:35416472 CREM -0.47 -5.38 -0.31 1.67e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs3820928 0.874 rs10195072 chr2:227794452 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.63 -0.33 4.51e-8 Pulmonary function; CESC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg06108461 chr20:60628389 TAF4 -0.5 -5.95 -0.34 8.26e-9 Obesity-related traits; CESC cis rs763121 0.744 rs5757140 chr22:38957013 T/C cg06544989 chr22:39130855 UNC84B 0.49 8.15 0.45 1.42e-14 Menopause (age at onset); CESC cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg23711669 chr6:146136114 FBXO30 -0.99 -14.35 -0.66 5.95e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs9911578 0.803 rs8069033 chr17:57131581 T/A cg05425664 chr17:57184151 TRIM37 0.53 7.36 0.41 2.26e-12 Intelligence (multi-trait analysis); CESC cis rs34779708 0.733 rs12777960 chr10:35541026 C/A cg03585969 chr10:35415529 CREM 0.56 6.42 0.37 6.15e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs948562 0.744 rs113392266 chr11:58219751 C/G cg24637035 chr12:120445227 CCDC64 -0.5 -6.06 -0.35 4.67e-9 Lymphoma; CESC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg23161317 chr6:28129485 ZNF389 0.46 6.19 0.36 2.32e-9 Parkinson's disease; CESC cis rs7927771 1.000 rs11605774 chr11:47832793 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -5.98 -0.34 7.23e-9 Subjective well-being; CESC cis rs7071206 0.947 rs716255 chr10:79419679 A/T cg07817648 chr10:79422355 NA -0.85 -10.89 -0.56 4.71e-23 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15498283 chr11:747520 TALDO1 0.56 6.37 0.36 8.55e-10 Gut microbiome composition (summer); CESC cis rs1372520 0.567 rs2619349 chr4:90746646 G/T cg15133208 chr4:90757351 SNCA -0.4 -5.42 -0.32 1.34e-7 Neuroticism; CESC cis rs10949834 1.000 rs11770302 chr7:73485252 G/C cg07137043 chr7:73588983 EIF4H -0.63 -5.24 -0.31 3.26e-7 Verbal memory performance (residualized delayed recall change); CESC cis rs3820068 0.822 rs2901964 chr1:15792426 C/G cg16988262 chr1:15930761 NA 0.35 5.54 0.32 7.38e-8 Systolic blood pressure; CESC cis rs453301 0.682 rs2929451 chr8:9085295 A/T cg06636001 chr8:8085503 FLJ10661 0.54 7.4 0.41 1.81e-12 Joint mobility (Beighton score); CESC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.66 0.38 1.54e-10 Bipolar disorder; CESC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg18252515 chr7:66147081 NA 0.44 5.85 0.34 1.48e-8 Aortic root size; CESC trans rs2488397 0.750 rs35939830 chr1:197561510 C/T cg13426224 chr12:133196447 P2RX2 -0.46 -6.01 -0.35 6.2e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.15 0.3 5.06e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9303401 0.646 rs7213269 chr17:57237796 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.56 7.32 0.41 2.93e-12 Cognitive test performance; CESC cis rs7179456 0.513 rs593742 chr15:59045774 A/G cg05156742 chr15:59063176 FAM63B 0.55 6.74 0.38 9.99e-11 Asperger disorder; CESC cis rs4523957 0.786 rs28524880 chr17:2125444 C/A cg16513277 chr17:2031491 SMG6 -0.62 -8.67 -0.47 4.51e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6445797 0.855 rs7646924 chr3:56570947 G/C cg13792233 chr3:56591045 CCDC66 -0.38 -5.26 -0.31 2.98e-7 Gastritis; CESC cis rs919433 0.889 rs787995 chr2:198216853 T/G cg03934865 chr2:198174659 NA 0.44 6.47 0.37 4.71e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs854765 0.822 rs1889014 chr17:17767165 C/T cg04398451 chr17:18023971 MYO15A 0.6 8.25 0.45 7.68e-15 Total body bone mineral density; CESC cis rs80130819 0.688 rs11168455 chr12:48592792 G/A cg07561017 chr12:48398056 COL2A1 0.38 5.11 0.3 6.08e-7 Prostate cancer; CESC cis rs738144 0.542 rs4303811 chr22:39157755 A/G cg06022373 chr22:39101656 GTPBP1 -0.55 -5.3 -0.31 2.42e-7 IgG glycosylation; CESC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.62 8.63 0.47 5.7e-16 Bipolar disorder; CESC cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg12365402 chr11:9010492 NRIP3 -0.33 -5.25 -0.31 3.14e-7 Hemoglobin concentration; CESC cis rs17253792 0.822 rs75663029 chr14:56092385 T/C cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08597319 chr8:103876573 AZIN1 -0.49 -6.22 -0.36 1.88e-9 Ulcerative colitis; CESC cis rs787274 0.543 rs1324930 chr9:115634639 A/G cg13803584 chr9:115635662 SNX30 0.64 5.98 0.34 7.3e-9 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05543547 chr10:119135213 PDZD8 0.53 6.01 0.35 6.18e-9 Gut microbiome composition (summer); CESC cis rs10504073 0.647 rs10808744 chr8:49988984 A/G cg00325661 chr8:49890786 NA 0.54 7.92 0.44 6.4e-14 Blood metabolite ratios; CESC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg03576123 chr11:487126 PTDSS2 -1.12 -11.21 -0.57 3.93e-24 Body mass index; CESC cis rs7826238 0.566 rs2945886 chr8:8148270 C/G cg06636001 chr8:8085503 FLJ10661 0.61 7.96 0.44 5e-14 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01985186 chr16:31448002 ZNF843 -0.5 -6.02 -0.35 5.81e-9 Gut microbiome composition (summer); CESC cis rs7107174 1.000 rs2373115 chr11:78091150 G/T cg02023728 chr11:77925099 USP35 0.41 6.01 0.35 6.21e-9 Testicular germ cell tumor; CESC cis rs6580649 0.941 rs7312326 chr12:48480643 G/A cg24011408 chr12:48396354 COL2A1 -0.4 -5.04 -0.3 8.67e-7 Lung cancer; CESC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg21248554 chr2:27665150 KRTCAP3 -0.37 -7.68 -0.43 3.02e-13 Total body bone mineral density; CESC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg22963979 chr7:1858916 MAD1L1 -0.39 -5.32 -0.31 2.26e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7385804 0.766 rs1734909 chr7:100309582 C/G cg16850897 chr7:100343110 ZAN 0.47 6.41 0.37 6.69e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg23048001 chr7:2026167 MAD1L1 0.47 6.11 0.35 3.5e-9 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05815920 chr10:103880348 LDB1 0.56 6.31 0.36 1.17e-9 Gut microbiome composition (summer); CESC cis rs11745587 0.539 rs6897597 chr5:131743465 C/T cg21138405 chr5:131827807 IRF1 0.36 5.54 0.32 7.4e-8 Asthma; CESC trans rs1814175 0.702 rs4881644 chr11:49786367 C/T cg03929089 chr4:120376271 NA -0.9 -14.71 -0.67 3.25e-36 Height; CESC trans rs3087243 0.728 rs231734 chr2:204694280 G/A cg01841312 chr10:38069945 NA 0.4 6.76 0.38 8.92e-11 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs12477438 0.784 rs13407840 chr2:99569928 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.59 -0.47 7.8e-16 Chronic sinus infection; CESC cis rs6732160 0.564 rs1430346 chr2:73367245 T/C cg01422370 chr2:73384389 NA 0.57 8.83 0.48 1.43e-16 Intelligence (multi-trait analysis); CESC trans rs9467711 0.606 rs9379858 chr6:26367689 T/C cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC cis rs4253772 0.550 rs715515 chr22:46720921 G/A cg18190219 chr22:46762943 CELSR1 -0.59 -5.82 -0.34 1.71e-8 LDL cholesterol;Cholesterol, total; CESC cis rs11098499 0.954 rs10024844 chr4:120311528 A/G cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg17372223 chr3:52568218 NT5DC2 0.56 9.65 0.51 4.61e-19 Electroencephalogram traits; CESC cis rs11690935 0.550 rs62183784 chr2:172866696 A/G cg13550731 chr2:172543902 DYNC1I2 0.49 6.76 0.38 8.6e-11 Schizophrenia; CESC trans rs17685 0.672 rs1639623 chr7:75707951 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 12.47 0.61 2.13e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.77 0.33 2.18e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12973672 0.812 rs12986033 chr19:35748782 A/G cg12095397 chr19:35769544 USF2 0.49 5.97 0.34 7.44e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs965469 1.000 rs2236107 chr20:3285821 C/T cg25506879 chr20:3388711 C20orf194 -0.57 -5.91 -0.34 1.04e-8 IFN-related cytopenia; CESC cis rs2735413 0.875 rs8055298 chr16:78084868 C/G cg04733911 chr16:78082701 NA 0.54 9.1 0.49 2.18e-17 Systolic blood pressure (alcohol consumption interaction); CESC trans rs7604827 0.915 rs73072790 chr2:215330774 C/T cg26520399 chr15:25332888 SNORD116-20;SNORD116-21 0.48 6.06 0.35 4.74e-9 PR interval; CESC cis rs3741151 0.656 rs73550316 chr11:73299799 G/A cg17517138 chr11:73019481 ARHGEF17 1.02 7.43 0.42 1.51e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs656900 0.874 rs622506 chr15:80139195 A/C cg02196730 chr15:80188777 MTHFS -0.43 -5.52 -0.32 8.05e-8 Cerebrospinal P-tau181p levels; CESC cis rs2115630 0.645 rs2292463 chr15:85175750 A/G cg11189052 chr15:85197271 WDR73 -0.47 -6.36 -0.36 8.61e-10 P wave terminal force; CESC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg04944784 chr2:26401820 FAM59B -0.64 -7.31 -0.41 3.21e-12 Gut microbiome composition (summer); CESC cis rs12586317 0.547 rs77262907 chr14:35495734 C/G cg16230307 chr14:35515116 FAM177A1 0.99 10.61 0.55 3.72e-22 Psoriasis; CESC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg25072359 chr17:41440525 NA 0.44 5.91 0.34 1.06e-8 Menopause (age at onset); CESC cis rs7666738 0.791 rs13146909 chr4:98934198 C/T cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11166629 0.502 rs2439813 chr8:135669158 C/T cg27224718 chr8:135614730 ZFAT 0.41 5.09 0.3 6.86e-7 Smoking quantity; CESC cis rs79057730 0.528 rs6965219 chr7:821807 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.68 6.15 0.35 2.91e-9 Initial pursuit acceleration; CESC cis rs2228479 0.717 rs2074904 chr16:89811546 A/G cg04013166 chr16:89971882 TCF25 0.79 6.78 0.38 7.83e-11 Skin colour saturation; CESC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg22535103 chr8:58192502 C8orf71 -0.92 -10.16 -0.53 1.04e-20 Developmental language disorder (linguistic errors); CESC cis rs881375 0.900 rs2241003 chr9:123666777 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 5.94 0.34 8.87e-9 Rheumatoid arthritis; CESC cis rs4481887 0.962 rs12037921 chr1:248454167 T/G cg00666640 chr1:248458726 OR2T12 0.38 6.24 0.36 1.7e-9 Common traits (Other); CESC cis rs9611565 0.694 rs5751107 chr22:41857812 A/G cg06634786 chr22:41940651 POLR3H 0.72 7.39 0.41 1.94e-12 Vitiligo; CESC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg05279229 chr7:1896384 MAD1L1 -0.39 -5.11 -0.3 6.13e-7 Bipolar disorder and schizophrenia; CESC cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg20607287 chr7:12443886 VWDE -0.77 -8.7 -0.47 3.63e-16 Coronary artery disease; CESC cis rs9916302 0.706 rs8067511 chr17:37611352 C/T cg07936489 chr17:37558343 FBXL20 -0.92 -9.65 -0.51 4.39e-19 Glomerular filtration rate (creatinine); CESC cis rs7208859 0.573 rs56031503 chr17:29075665 T/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.19 0.3 4.21e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16978263 chr3:160118452 SMC4;IFT80 0.48 6.11 0.35 3.54e-9 Gut microbiota (bacterial taxa); CESC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg26343298 chr8:95960752 TP53INP1 0.35 5.83 0.34 1.57e-8 Type 2 diabetes; CESC cis rs731174 0.802 rs502776 chr1:38182164 T/A cg12339802 chr1:38156545 C1orf109 -0.5 -5.2 -0.3 4.01e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs13256369 0.708 rs11783670 chr8:8559394 G/A cg17143192 chr8:8559678 CLDN23 0.77 8.63 0.47 5.79e-16 Obesity-related traits; CESC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg04414720 chr1:150670196 GOLPH3L 0.5 6.49 0.37 4.21e-10 Melanoma; CESC cis rs35955841 0.569 rs12437108 chr14:65309550 G/A cg23373153 chr14:65346875 NA 0.44 5.76 0.33 2.32e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg23281280 chr6:28129359 ZNF389 0.59 7.91 0.44 6.86e-14 Depression; CESC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.83 -9.25 -0.49 7.55e-18 Gut microbiome composition (summer); CESC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg04772025 chr11:68637568 NA 0.57 6.59 0.38 2.35e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1595825 0.891 rs7580003 chr2:198517893 C/T cg10820045 chr2:198174542 NA 0.41 5.17 0.3 4.69e-7 Ulcerative colitis; CESC cis rs1008375 1.000 rs10805358 chr4:17652450 A/C cg16339924 chr4:17578868 LAP3 0.55 6.83 0.39 5.88e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs7937682 1.000 rs12363179 chr11:111568091 G/A cg22437258 chr11:111473054 SIK2 -0.68 -7.83 -0.43 1.19e-13 Primary sclerosing cholangitis; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg01814833 chr7:75623698 TMEM120A -0.53 -6.05 -0.35 5.04e-9 Gut microbiota (bacterial taxa); CESC cis rs1879734 0.636 rs12080903 chr1:54178270 G/A cg23596471 chr1:54105337 GLIS1 0.31 5.03 0.3 8.88e-7 Mitral valve prolapse; CESC cis rs1003719 0.742 rs8129231 chr21:38501034 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.21 -0.45 9.49e-15 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09302448 chr16:67562672 FAM65A 0.62 7.13 0.4 9.71e-12 Gut microbiome composition (summer); CESC cis rs854765 0.547 rs2955383 chr17:17941364 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.56 8.0 0.44 3.85e-14 Total body bone mineral density; CESC cis rs12477438 0.520 rs4851187 chr2:99745860 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.86 -16.29 -0.71 7.94e-42 Chronic sinus infection; CESC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg24829409 chr8:58192753 C8orf71 -0.7 -7.79 -0.43 1.49e-13 Developmental language disorder (linguistic errors); CESC cis rs6060717 0.610 rs2794382 chr20:34613651 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.5 6.32 0.36 1.13e-9 Hip circumference adjusted for BMI; CESC cis rs4975709 0.801 rs3797063 chr5:1881549 A/T cg12288994 chr5:1860383 NA 0.37 5.84 0.34 1.53e-8 Cardiovascular disease risk factors; CESC cis rs12545109 0.765 rs2576589 chr8:57425647 C/T cg09654669 chr8:57350985 NA -0.61 -6.85 -0.39 5.2e-11 Obesity-related traits; CESC cis rs2404602 0.563 rs12914005 chr15:76765667 A/G cg26408565 chr15:76604113 ETFA -0.43 -6.43 -0.37 5.86e-10 Blood metabolite levels; CESC cis rs782590 0.967 rs1975484 chr2:55803167 T/A cg18811423 chr2:55921094 PNPT1 0.8 12.92 0.62 6.23e-30 Metabolic syndrome; CESC cis rs4423214 0.592 rs10898186 chr11:71188800 G/A cg05163923 chr11:71159392 DHCR7 -0.54 -5.76 -0.33 2.36e-8 Vitamin D levels; CESC cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg24633756 chr6:26577808 NA -0.37 -5.61 -0.33 5.13e-8 Intelligence (multi-trait analysis); CESC cis rs12200560 0.505 rs211175 chr6:97073320 C/T cg06623918 chr6:96969491 KIAA0776 0.5 6.43 0.37 5.95e-10 Coronary heart disease; CESC cis rs863345 0.604 rs1342947 chr1:158459714 G/A cg12129480 chr1:158549410 OR10X1 -0.36 -7.14 -0.4 8.93e-12 Pneumococcal bacteremia; CESC cis rs9768139 0.903 rs28503558 chr7:158119568 C/T cg06219351 chr7:158114137 PTPRN2 0.49 7.69 0.43 2.82e-13 Calcium levels; CESC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.83 8.24 0.45 7.99e-15 Platelet count; CESC cis rs2749592 0.550 rs7081464 chr10:37883937 C/T cg25427524 chr10:38739819 LOC399744 0.54 7.36 0.41 2.31e-12 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.5 8.8 0.48 1.8e-16 Monocyte percentage of white cells; CESC cis rs2228479 0.850 rs2190808 chr16:89840856 C/T cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs2075671 0.855 rs11974395 chr7:100282538 G/A cg16850897 chr7:100343110 ZAN -0.7 -8.88 -0.48 1.04e-16 Other erythrocyte phenotypes; CESC cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg08847533 chr14:75593920 NEK9 0.92 16.29 0.71 8.22e-42 Height; CESC cis rs3806843 0.735 rs2563335 chr5:140044292 A/C cg26395211 chr5:140044315 WDR55 -0.48 -6.06 -0.35 4.75e-9 Depressive symptoms (multi-trait analysis); CESC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.06 0.3 7.92e-7 Menopause (age at onset); CESC cis rs2014572 0.904 rs10412465 chr19:57753931 T/C cg24459738 chr19:57751996 ZNF805 -0.57 -8.01 -0.44 3.74e-14 Hyperactive-impulsive symptoms; CESC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg07308232 chr7:1071921 C7orf50 -0.41 -5.59 -0.32 5.56e-8 Longevity;Endometriosis; CESC cis rs10876993 0.928 rs1689596 chr12:58053029 T/C cg18357645 chr12:58087776 OS9 0.63 9.92 0.52 6.15e-20 Celiac disease or Rheumatoid arthritis; CESC cis rs9457247 0.935 rs1794697 chr6:167395410 C/T cg07741184 chr6:167504864 NA 0.29 5.18 0.3 4.34e-7 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12498654 chr6:139456103 HECA 0.53 6.0 0.35 6.54e-9 Gut microbiome composition (summer); CESC cis rs9581857 0.579 rs75872792 chr13:27996064 G/T cg22138327 chr13:27999177 GTF3A 0.64 5.41 0.32 1.43e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs3741151 0.773 rs7951072 chr11:73221721 G/A cg17517138 chr11:73019481 ARHGEF17 0.98 7.25 0.41 4.61e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs8049040 0.609 rs4258624 chr16:71467951 C/T cg08717414 chr16:71523259 ZNF19 0.54 6.34 0.36 1.01e-9 Blood protein levels; CESC cis rs4566357 0.595 rs1320406 chr2:227920474 C/T cg11843606 chr2:227700838 RHBDD1 -0.51 -7.3 -0.41 3.4e-12 Coronary artery disease; CESC cis rs11077998 0.933 rs6502121 chr17:80531314 A/G cg10255544 chr17:80519551 FOXK2 0.55 8.73 0.47 2.83e-16 Reticulocyte fraction of red cells; CESC cis rs3761218 0.738 rs4815604 chr20:3772913 C/T cg25011176 chr20:3776985 CDC25B -0.42 -5.52 -0.32 7.89e-8 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14546712 chr8:41478669 AGPAT6 0.53 6.94 0.39 2.94e-11 Fibrinogen levels; CESC cis rs7223966 1.000 rs7223672 chr17:61720565 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.63 0.38 1.84e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs11809207 0.501 rs3762460 chr1:26495550 A/G cg00147160 chr1:26503991 CNKSR1 0.3 5.75 0.33 2.47e-8 Height; CESC cis rs9948 0.786 rs62156230 chr2:97424915 A/G cg01990225 chr2:97406019 LMAN2L -0.86 -7.49 -0.42 1.03e-12 Erectile dysfunction and prostate cancer treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03729566 chr7:1059678 C7orf50 -0.59 -6.62 -0.38 1.98e-10 Gut microbiome composition (summer); CESC cis rs1729951 0.575 rs361243 chr3:136697786 C/T cg25687071 chr3:136751404 NA 0.4 5.33 0.31 2.15e-7 Neuroticism; CESC cis rs9467711 0.606 rs9379858 chr6:26367689 T/C cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7605827 0.897 rs11675604 chr2:15672901 C/T cg19274914 chr2:15703543 NA 0.33 5.76 0.33 2.28e-8 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09102409 chr8:134308734 NDRG1 -0.61 -7.49 -0.42 1.05e-12 Gut microbiome composition (summer); CESC cis rs7914558 0.966 rs7921574 chr10:104840970 T/C cg04362960 chr10:104952993 NT5C2 0.47 6.12 0.35 3.36e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2282802 0.685 rs13170475 chr5:139671062 C/T cg26211634 chr5:139558579 C5orf32 0.48 6.99 0.39 2.17e-11 Intelligence (multi-trait analysis); CESC cis rs734999 0.505 rs4073285 chr1:2539796 C/T cg18854424 chr1:2615690 NA 0.3 5.83 0.34 1.57e-8 Ulcerative colitis; CESC cis rs4704187 0.687 rs7709707 chr5:74363575 T/G cg03227963 chr5:74354835 NA 0.31 5.71 0.33 2.97e-8 Response to amphetamines; CESC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg04166393 chr7:2884313 GNA12 0.59 7.78 0.43 1.66e-13 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03488284 chr16:23607835 NDUFAB1 -0.47 -6.29 -0.36 1.31e-9 Fibrinogen levels; CESC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.41e-28 Prudent dietary pattern; CESC cis rs1552244 0.608 rs3732962 chr3:10048951 T/C cg00149659 chr3:10157352 C3orf10 0.53 6.51 0.37 3.81e-10 Alzheimer's disease; CESC trans rs208520 0.609 rs208436 chr6:66897470 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.66 -8.07 -0.44 2.54e-14 Exhaled nitric oxide output; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23262030 chr17:45918702 SCRN2 -0.48 -6.07 -0.35 4.29e-9 Ulcerative colitis; CESC cis rs3820068 0.577 rs41270271 chr1:15913582 G/C cg17385448 chr1:15911702 AGMAT 0.43 6.71 0.38 1.15e-10 Systolic blood pressure; CESC cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg19717773 chr7:2847554 GNA12 -0.58 -9.13 -0.49 1.87e-17 Height; CESC cis rs2997447 0.761 rs17356867 chr1:26448849 C/T cg24596570 chr1:26146463 FAM54B;LOC646471 -0.59 -5.37 -0.31 1.76e-7 QRS complex (12-leadsum); CESC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg18135555 chr8:22132992 PIWIL2 0.25 5.26 0.31 2.92e-7 Hypertriglyceridemia; CESC cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg05347473 chr6:146136440 FBXO30 -0.56 -7.08 -0.4 1.29e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 12.86 0.62 9.49e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg27398817 chr8:82754497 SNX16 0.56 6.44 0.37 5.68e-10 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25886337 chr2:73441702 SMYD5 0.61 6.88 0.39 4.33e-11 Gut microbiome composition (summer); CESC cis rs2070997 0.816 rs6597642 chr9:133725767 C/T cg11464064 chr9:133710261 ABL1 0.55 5.57 0.32 6.37e-8 Response to amphetamines; CESC cis rs7772486 0.875 rs2814875 chr6:146305810 G/A cg23711669 chr6:146136114 FBXO30 0.9 13.1 0.63 1.45e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs3733585 0.673 rs10000983 chr4:9951606 T/C cg11266682 chr4:10021025 SLC2A9 -0.59 -11.13 -0.56 7.1e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3925075 1.000 rs4506917 chr16:31347350 T/G cg02846316 chr16:31340340 ITGAM 0.41 6.52 0.37 3.54e-10 IgA nephropathy; CESC cis rs56104184 0.775 rs55737338 chr19:49403141 A/G cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs9908102 0.740 rs55883319 chr17:12907513 G/C cg26162695 chr17:12921313 ELAC2 0.51 5.64 0.33 4.33e-8 Schizophrenia; CESC cis rs5753618 0.504 rs8142121 chr22:31882785 G/A cg02404636 chr22:31891804 SFI1 0.4 5.3 0.31 2.39e-7 Colorectal cancer; CESC cis rs4835473 0.831 rs4323050 chr4:144913259 T/C cg25736465 chr4:144833511 NA 0.43 6.44 0.37 5.61e-10 Immature fraction of reticulocytes; CESC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.0 10.3 0.53 3.82e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12142240 0.698 rs41293285 chr1:46808426 C/T cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs8050907 0.590 rs17137096 chr16:4558553 C/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.8 5.38 0.31 1.61e-7 Obesity-related traits; CESC cis rs6500395 1.000 rs12919520 chr16:48705760 G/C cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg06634786 chr22:41940651 POLR3H 0.69 7.02 0.4 1.86e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs9581857 0.579 rs75024088 chr13:27970105 G/T cg01674679 chr13:27998804 GTF3A -0.67 -5.25 -0.31 3.15e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs2455799 0.574 rs2470534 chr3:15701054 C/G cg16303742 chr3:15540471 COLQ 0.39 6.27 0.36 1.47e-9 Mean platelet volume; CESC cis rs8060686 0.920 rs16942887 chr16:67928042 G/A cg26727032 chr16:67993705 SLC12A4 -0.57 -6.74 -0.38 1e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg08736216 chr1:53307985 ZYG11A -0.4 -6.79 -0.38 7.53e-11 Monocyte count; CESC cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg00033643 chr7:134001901 SLC35B4 0.41 5.28 0.31 2.7e-7 Mean platelet volume; CESC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg22638593 chr5:131593259 PDLIM4 0.42 5.43 0.32 1.26e-7 Breast cancer; CESC cis rs933688 1.000 rs4382199 chr5:90744228 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 12.03 0.59 6.99e-27 Smoking behavior; CESC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg09455208 chr3:40491958 NA 0.45 7.84 0.43 1.1e-13 Renal cell carcinoma; CESC cis rs60154123 0.730 rs587203 chr1:210463786 C/T cg23283495 chr1:209979779 IRF6 0.38 5.11 0.3 6.31e-7 Coronary artery disease; CESC cis rs7267979 0.932 rs6138600 chr20:25521346 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.76 13.66 0.64 1.58e-32 Liver enzyme levels (alkaline phosphatase); CESC trans rs7615952 0.641 rs7640158 chr3:125808011 G/A cg07211511 chr3:129823064 LOC729375 -0.56 -6.22 -0.36 1.92e-9 Blood pressure (smoking interaction); CESC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg03806693 chr22:41940476 POLR3H 1.19 14.08 0.65 5.29e-34 Vitiligo; CESC cis rs116095464 0.558 rs10080225 chr5:232175 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.41 0.32 1.43e-7 Breast cancer; CESC cis rs3096299 0.900 rs2911258 chr16:89480760 A/G cg16743903 chr16:89593216 SPG7 -0.42 -5.35 -0.31 1.93e-7 Multiple myeloma (IgH translocation); CESC cis rs6598955 0.666 rs12759434 chr1:26607123 C/T cg00852783 chr1:26633632 UBXN11 0.42 6.11 0.35 3.58e-9 Obesity-related traits; CESC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg23590916 chr17:43697445 MGC57346 -0.64 -7.02 -0.4 1.84e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16558908 chr1:33896237 NA 0.54 6.07 0.35 4.47e-9 Gut microbiome composition (summer); CESC cis rs9549367 0.713 rs553316 chr13:113838015 A/G cg18105134 chr13:113819100 PROZ 0.55 7.11 0.4 1.1e-11 Platelet distribution width; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16248187 chr2:153191727 FMNL2 -0.5 -6.07 -0.35 4.46e-9 Ulcerative colitis; CESC cis rs2197308 0.715 rs11181816 chr12:37911626 A/G cg26384229 chr12:38710491 ALG10B -0.55 -7.85 -0.43 1.02e-13 Morning vs. evening chronotype; CESC cis rs3733585 0.648 rs35954357 chr4:9978758 G/C cg00071950 chr4:10020882 SLC2A9 0.69 11.14 0.56 6.55e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -8.67 -0.47 4.4e-16 Schizophrenia; CESC cis rs1008375 1.000 rs2315561 chr4:17679695 C/T cg16339924 chr4:17578868 LAP3 0.48 6.13 0.35 3.14e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg18876405 chr7:65276391 NA 0.48 5.52 0.32 8.06e-8 Aortic root size; CESC cis rs4319547 1.000 rs1392236 chr12:123074890 C/G cg05707623 chr12:122985044 ZCCHC8 -0.58 -6.75 -0.38 9.4e-11 Body mass index; CESC cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg25894440 chr7:65020034 NA -0.61 -5.12 -0.3 5.79e-7 Diabetic kidney disease; CESC cis rs9611565 0.921 rs2281332 chr22:41746212 T/C cg06481639 chr22:41940642 POLR3H -0.45 -5.25 -0.31 3.14e-7 Vitiligo; CESC cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg11752832 chr7:134001865 SLC35B4 0.52 6.73 0.38 1.04e-10 Mean platelet volume; CESC cis rs2072732 0.821 rs12034766 chr1:2944038 A/G cg03976712 chr1:2946727 NA 0.34 5.35 0.31 1.9e-7 Plateletcrit; CESC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg00262263 chr6:170184901 NA 0.44 6.63 0.38 1.88e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs728616 0.867 rs12414096 chr10:81713629 A/G cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2228479 0.764 rs35518096 chr16:89961140 C/A cg06558623 chr16:89946397 TCF25 0.69 6.1 0.35 3.69e-9 Skin colour saturation; CESC cis rs3820068 0.581 rs6692489 chr1:15928517 A/G cg13390004 chr1:15929781 NA 0.34 5.45 0.32 1.13e-7 Systolic blood pressure; CESC cis rs7927592 0.913 rs12294029 chr11:68257059 A/C cg20283391 chr11:68216788 NA -0.53 -6.41 -0.37 6.5e-10 Total body bone mineral density; CESC cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.82 -12.1 -0.6 3.83e-27 Systemic lupus erythematosus; CESC trans rs1814175 0.546 rs1614397 chr11:49913384 G/C cg03929089 chr4:120376271 NA -0.93 -15.69 -0.69 1.12e-39 Height; CESC cis rs6570726 0.905 rs452770 chr6:145847162 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.96e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg05457628 chr5:178986728 RUFY1 0.51 7.68 0.43 3.09e-13 Lung cancer; CESC cis rs698833 0.638 rs698786 chr2:44744897 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.42 5.18 0.3 4.3e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs7615952 0.576 rs4646759 chr3:125822946 G/C cg07211511 chr3:129823064 LOC729375 -0.57 -6.28 -0.36 1.38e-9 Blood pressure (smoking interaction); CESC cis rs2963155 0.518 rs55817235 chr5:142765733 C/T cg17617527 chr5:142782415 NR3C1 0.82 6.79 0.39 7.2e-11 Breast cancer; CESC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg19163074 chr7:65112434 INTS4L2 -0.46 -5.5 -0.32 8.86e-8 Calcium levels; CESC cis rs919433 0.926 rs787997 chr2:198216271 A/G cg03934865 chr2:198174659 NA 0.44 6.49 0.37 4.2e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs734999 0.545 rs4648356 chr1:2709164 C/A cg20673091 chr1:2541236 MMEL1 0.48 7.84 0.43 1.07e-13 Ulcerative colitis; CESC cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg20891283 chr12:69753455 YEATS4 0.89 14.3 0.66 9.23e-35 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02588659 chr11:45826627 SLC35C1 0.63 6.87 0.39 4.67e-11 Gut microbiome composition (summer); CESC cis rs11098499 0.818 rs10008791 chr4:120431469 A/C cg24375607 chr4:120327624 NA 0.44 5.27 0.31 2.85e-7 Corneal astigmatism; CESC cis rs113601626 1 rs113601626 chr2:24239189 T/TCCTGGC cg08917208 chr2:24149416 ATAD2B 1.13 9.83 0.52 1.17e-19 Lymphocyte percentage of white cells; CESC cis rs7188697 0.922 rs4471670 chr16:58601365 G/A cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg18876405 chr7:65276391 NA -0.53 -7.16 -0.4 7.93e-12 Aortic root size; CESC cis rs2439831 0.867 rs2447211 chr15:43936351 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.69 8.5 0.46 1.35e-15 Lung cancer in ever smokers; CESC trans rs6089829 0.890 rs6062775 chr20:61663650 T/C cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs2637266 0.905 rs34173296 chr10:78343389 C/T cg18941641 chr10:78392320 NA 0.4 7.36 0.41 2.26e-12 Pulmonary function; CESC cis rs7809950 0.678 rs2301801 chr7:106870746 T/C cg23024343 chr7:107201750 COG5 -0.55 -7.01 -0.4 1.98e-11 Coronary artery disease; CESC cis rs10170846 0.893 rs12614976 chr2:223542896 A/T cg25565276 chr2:223520875 FARSB 0.57 7.92 0.44 6.64e-14 Schizophrenia (inflammation and infection response interaction); CESC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs9291683 0.588 rs2240722 chr4:10020757 A/G cg11266682 chr4:10021025 SLC2A9 0.72 14.83 0.67 1.25e-36 Bone mineral density; CESC cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg02297831 chr4:17616191 MED28 -0.53 -6.26 -0.36 1.51e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6430585 0.591 rs12466487 chr2:136407078 C/T cg07169764 chr2:136633963 MCM6 -1.13 -11.55 -0.58 2.9e-25 Corneal structure; CESC cis rs3767633 0.800 rs2880055 chr1:161922365 C/T cg09175582 chr1:161736000 ATF6 0.77 6.62 0.38 1.95e-10 IgG glycosylation; CESC cis rs897984 0.683 rs9932572 chr16:30841642 A/G cg02466173 chr16:30829666 NA -0.6 -11.55 -0.58 2.97e-25 Dementia with Lewy bodies; CESC trans rs35110281 0.807 rs9984002 chr21:45061501 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 7.22 0.41 5.57e-12 Mean corpuscular volume; CESC cis rs8062405 0.573 rs6565300 chr16:28993049 G/T cg05966235 chr16:28915196 ATP2A1 0.36 5.2 0.3 4.04e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9443645 0.527 rs1415859 chr6:79794858 A/G cg05283184 chr6:79620031 NA -0.39 -5.58 -0.32 5.88e-8 Intelligence (multi-trait analysis); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg20930618 chr1:151162157 VPS72 -0.41 -6.13 -0.35 3.1e-9 Vertical cup-disc ratio; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08492205 chr10:103879827 LDB1 -0.45 -6.1 -0.35 3.65e-9 Gut microbiota (bacterial taxa); CESC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg07936489 chr17:37558343 FBXL20 0.8 11.69 0.58 9.64e-26 Glomerular filtration rate (creatinine); CESC cis rs16867321 0.950 rs4667228 chr2:181498824 T/A cg23363182 chr2:181467187 NA -0.43 -5.69 -0.33 3.39e-8 Obesity; CESC cis rs7208859 0.623 rs80355557 chr17:29154421 C/T cg19761014 chr17:28927070 LRRC37B2 0.72 5.91 0.34 1.03e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6580649 0.883 rs4075913 chr12:48537624 A/G cg05342945 chr12:48394962 COL2A1 -0.54 -6.26 -0.36 1.54e-9 Lung cancer; CESC cis rs2637266 1.000 rs12251568 chr10:78345667 C/T cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.54e-13 Pulmonary function; CESC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg24675658 chr1:53192096 ZYG11B -0.66 -9.13 -0.49 1.78e-17 Monocyte count; CESC cis rs1986734 0.576 rs4624677 chr4:77420406 T/C cg20311846 chr4:77356250 SHROOM3 -0.28 -5.68 -0.33 3.62e-8 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg26839252 chr6:160211577 TCP1;MRPL18 -0.43 -5.41 -0.32 1.39e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs9457247 0.602 rs9457262 chr6:167473685 A/G cg23791538 chr6:167370224 RNASET2 -0.52 -6.9 -0.39 3.81e-11 Crohn's disease; CESC cis rs11139399 0.650 rs6559640 chr9:84349735 G/A cg07852945 chr9:84303915 TLE1 0.37 5.51 0.32 8.35e-8 Hippocampal atrophy; CESC cis rs6570726 0.935 rs419847 chr6:145827278 A/G cg23711669 chr6:146136114 FBXO30 0.79 11.77 0.59 5.16e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs62005083 1.000 rs62006778 chr14:74644121 A/G cg05179529 chr14:74551516 LIN52;ALDH6A1 0.71 5.52 0.32 7.97e-8 Mean corpuscular volume; CESC cis rs9908102 0.740 rs56375019 chr17:12909790 G/A cg26162695 chr17:12921313 ELAC2 0.52 5.67 0.33 3.77e-8 Schizophrenia; CESC cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg04455712 chr21:45112962 RRP1B 0.39 5.84 0.34 1.53e-8 Mean corpuscular volume; CESC cis rs4727027 0.631 rs62507511 chr7:148796080 C/A cg23158103 chr7:148848205 ZNF398 -0.4 -6.31 -0.36 1.15e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4555082 0.957 rs2735818 chr14:105714751 A/G cg06808227 chr14:105710500 BRF1 -0.55 -6.73 -0.38 1.03e-10 Mean platelet volume;Platelet distribution width; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12876261 chr7:56119223 PSPH;CCT6A -0.44 -6.28 -0.36 1.35e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs34638657 0.827 rs6564996 chr16:82207542 T/C cg09439754 chr16:82129088 HSD17B2 -0.37 -5.27 -0.31 2.84e-7 Lung adenocarcinoma; CESC cis rs7809799 0.826 rs73147651 chr7:98781440 G/C cg05967295 chr7:98741636 SMURF1 0.88 5.54 0.32 7.27e-8 Ulcerative colitis; CESC trans rs11039798 0.557 rs4441015 chr11:49027070 A/G cg15704280 chr7:45808275 SEPT13 0.68 6.88 0.39 4.2e-11 Axial length; CESC trans rs9354308 0.840 rs1827157 chr6:66615761 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.65 7.07 0.4 1.36e-11 Metabolite levels; CESC cis rs9527 0.571 rs4917985 chr10:104624072 C/T cg04362960 chr10:104952993 NT5C2 0.48 5.97 0.34 7.73e-9 Arsenic metabolism; CESC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg02461776 chr11:598696 PHRF1 0.52 6.1 0.35 3.7e-9 Systemic lupus erythematosus; CESC cis rs9549367 0.713 rs9549356 chr13:113851633 A/G cg00898013 chr13:113819073 PROZ -0.56 -7.55 -0.42 7.02e-13 Platelet distribution width; CESC cis rs8014204 1.000 rs4553560 chr14:75334199 T/C cg26191576 chr14:75389716 RPS6KL1 0.37 5.28 0.31 2.73e-7 Caffeine consumption; CESC cis rs965469 0.779 rs6051752 chr20:3310452 C/T cg25506879 chr20:3388711 C20orf194 -0.49 -5.41 -0.32 1.42e-7 IFN-related cytopenia; CESC cis rs2479724 0.935 rs7753507 chr6:41784094 C/T cg17623882 chr6:41773611 USP49 0.41 5.95 0.34 8.52e-9 Menarche (age at onset); CESC cis rs34779708 0.733 rs4007271 chr10:35546611 C/T cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg22143856 chr6:28129313 ZNF389 0.46 5.83 0.34 1.58e-8 Parkinson's disease; CESC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.73 0.38 1.02e-10 Bipolar disorder; CESC cis rs2243480 1.000 rs34193460 chr7:65393110 A/G cg18252515 chr7:66147081 NA -1.23 -11.37 -0.57 1.14e-24 Diabetic kidney disease; CESC cis rs1153858 1.000 rs12441971 chr15:45671957 A/T cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs72772090 0.539 rs111886458 chr5:96125047 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.26 -0.31 3.01e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1881797 1.000 rs10158379 chr1:247686352 C/A cg21399703 chr1:247681439 NA 0.55 7.37 0.41 2.13e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs698833 0.962 rs698828 chr2:44730577 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.49 6.05 0.35 4.93e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs727505 0.607 rs59635547 chr7:124796371 A/C cg23710748 chr7:124431027 NA -0.39 -6.05 -0.35 4.87e-9 Lewy body disease; CESC cis rs11098499 0.629 rs28369518 chr4:120271630 T/C cg09307838 chr4:120376055 NA 0.77 10.19 0.53 8.72e-21 Corneal astigmatism; CESC trans rs1814175 0.646 rs1722010 chr11:49897958 A/G cg03929089 chr4:120376271 NA -0.9 -14.75 -0.67 2.44e-36 Height; CESC cis rs7044106 0.762 rs1470307 chr9:123433039 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.76 0.33 2.37e-8 Hip circumference adjusted for BMI; CESC cis rs858239 0.636 rs28706766 chr7:23169834 T/A cg23682824 chr7:23144976 KLHL7 0.48 6.64 0.38 1.75e-10 Cerebrospinal fluid biomarker levels; CESC cis rs2952156 0.920 rs2517957 chr17:37838716 G/A cg20243544 chr17:37824526 PNMT 0.62 8.16 0.45 1.36e-14 Asthma; CESC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg00815214 chr21:47717953 NA 0.43 6.27 0.36 1.49e-9 Testicular germ cell tumor; CESC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC trans rs11989744 1.000 rs17782264 chr8:23570489 C/T cg03492747 chr16:86543808 FOXF1 0.6 7.07 0.4 1.38e-11 Waist-hip ratio; CESC cis rs3806843 0.771 rs801174 chr5:140112712 C/T cg26395211 chr5:140044315 WDR55 0.47 6.08 0.35 4.27e-9 Depressive symptoms (multi-trait analysis); CESC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg18404041 chr3:52824283 ITIH1 0.36 6.13 0.35 3.21e-9 Electroencephalogram traits; CESC cis rs10504229 0.639 rs112926738 chr8:58054939 A/G cg02725872 chr8:58115012 NA -0.41 -5.95 -0.34 8.38e-9 Developmental language disorder (linguistic errors); CESC cis rs9303401 0.580 rs12946396 chr17:57164195 T/A cg02118635 chr17:56770003 RAD51C;TEX14 1.0 12.81 0.62 1.44e-29 Cognitive test performance; CESC cis rs6088580 0.634 rs3746455 chr20:32957216 G/A cg24642439 chr20:33292090 TP53INP2 -0.51 -6.71 -0.38 1.18e-10 Glomerular filtration rate (creatinine); CESC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg27266027 chr21:40555129 PSMG1 0.47 5.63 0.33 4.49e-8 Cognitive function; CESC cis rs4718428 0.705 rs4718422 chr7:66359269 A/G cg12165864 chr7:66369176 NA -0.66 -7.66 -0.43 3.45e-13 Corneal structure; CESC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg10295955 chr4:187884368 NA -1.07 -21.24 -0.79 3.82e-59 Lobe attachment (rater-scored or self-reported); CESC cis rs6754311 0.731 rs7569057 chr2:136583958 A/C cg15123519 chr2:136567270 LCT -0.33 -5.62 -0.33 4.8e-8 Mosquito bite size; CESC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg07701084 chr6:150067640 NUP43 0.44 6.15 0.35 2.83e-9 Lung cancer; CESC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg02569458 chr12:86230093 RASSF9 -0.49 -7.38 -0.41 2e-12 Major depressive disorder; CESC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.23 0.41 5.23e-12 Height; CESC trans rs10488821 0.714 rs3781847 chr11:30518304 T/A cg04407762 chr4:113442791 NA -0.43 -6.07 -0.35 4.43e-9 QRS complex (12-leadsum); CESC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.92 10.3 0.53 3.87e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7223966 1.000 rs8068603 chr17:61755211 T/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.6 -0.33 5.23e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg07648498 chr16:89883185 FANCA 0.43 5.38 0.31 1.66e-7 Vitiligo; CESC cis rs5753618 0.555 rs9609302 chr22:31895987 A/C cg13145458 chr22:31556086 RNF185 -0.53 -6.25 -0.36 1.63e-9 Colorectal cancer; CESC cis rs1215050 0.791 rs1025201 chr4:98902938 A/G cg05340658 chr4:99064831 C4orf37 -0.53 -6.91 -0.39 3.69e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -12.15 -0.6 2.74e-27 Alzheimer's disease; CESC cis rs853679 1.000 rs853685 chr6:28288785 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.67 6.96 0.39 2.68e-11 Depression; CESC cis rs2645694 0.533 rs2645680 chr4:77820956 T/C cg10057126 chr4:77819792 ANKRD56 0.59 8.71 0.47 3.45e-16 Emphysema distribution in smoking; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02546208 chr12:1100009 ERC1 0.55 6.0 0.35 6.32e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21944557 chr1:179923876 CEP350 0.62 7.39 0.41 1.93e-12 Gut microbiome composition (summer); CESC cis rs7223966 1.000 rs8081612 chr17:61724695 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.58 -7.46 -0.42 1.23e-12 Hip circumference adjusted for BMI;Body mass index; CESC trans rs1814175 0.645 rs7103554 chr11:50027612 G/A cg11707556 chr5:10655725 ANKRD33B -0.41 -6.01 -0.35 6.08e-9 Height; CESC cis rs1395 0.778 rs34618115 chr2:27418289 G/A cg22903471 chr2:27725779 GCKR -0.42 -5.21 -0.3 3.81e-7 Blood metabolite levels; CESC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg22903471 chr2:27725779 GCKR 0.54 7.97 0.44 4.78e-14 Total body bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08905662 chr7:102789948 NAPEPLD -0.44 -6.12 -0.35 3.31e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3733585 0.673 rs6850143 chr4:9958924 T/C cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg23758822 chr17:41437982 NA -0.95 -15.74 -0.7 7.54e-40 Menopause (age at onset); CESC cis rs6754311 0.731 rs6719488 chr2:136575199 G/T cg15123519 chr2:136567270 LCT 0.33 5.62 0.33 4.81e-8 Mosquito bite size; CESC cis rs2072732 0.808 rs56091202 chr1:2936803 A/G cg15211996 chr1:2936768 ACTRT2 0.34 5.46 0.32 1.08e-7 Plateletcrit; CESC cis rs7659604 0.540 rs28672860 chr4:122705051 G/A cg19671926 chr4:122722719 EXOSC9 0.67 8.91 0.48 8.57e-17 Type 2 diabetes; CESC cis rs6866344 0.570 rs56236920 chr5:178144617 C/T cg03877680 chr5:178157825 ZNF354A 0.82 9.74 0.51 2.33e-19 Neutrophil percentage of white cells; CESC cis rs7084402 0.935 rs1649068 chr10:60304864 A/C cg07615347 chr10:60278583 BICC1 0.61 9.61 0.51 5.78e-19 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14182682 chr14:57857589 NAA30 -0.56 -6.31 -0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs7223966 1.000 rs8064261 chr17:61705212 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.07 -0.3 7.58e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9549260 0.755 rs7985364 chr13:41179580 C/G cg21288729 chr13:41239152 FOXO1 0.6 7.4 0.41 1.82e-12 Red blood cell count; CESC cis rs9649465 1.000 rs6963231 chr7:123374766 A/G cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.46e-7 Migraine; CESC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg15145296 chr3:125709740 NA -0.49 -5.31 -0.31 2.36e-7 Blood pressure (smoking interaction); CESC cis rs5758659 1.000 rs134902 chr22:42683997 C/T cg05082376 chr22:42548792 NA -0.34 -5.24 -0.31 3.28e-7 Cognitive function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23324888 chr5:111093475 C5orf13 -0.46 -6.37 -0.36 8.49e-10 Fibrinogen levels; CESC cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg22875332 chr1:76189707 ACADM 0.69 9.24 0.49 8.13e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9303401 0.527 rs12939313 chr17:56755616 A/T cg02118635 chr17:56770003 RAD51C;TEX14 1.01 11.02 0.56 1.64e-23 Cognitive test performance; CESC cis rs1976403 0.659 rs10799701 chr1:21820990 A/G cg02390115 chr1:21767211 NBPF3 0.39 5.66 0.33 3.95e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7772486 0.875 rs11155452 chr6:146424631 C/T cg23711669 chr6:146136114 FBXO30 0.86 12.72 0.62 2.98e-29 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02265318 chr1:220960539 MOSC1 0.58 7.3 0.41 3.37e-12 Gut microbiome composition (summer); CESC trans rs208520 0.690 rs1304672 chr6:66847973 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 9.27 0.49 6.82e-18 Exhaled nitric oxide output; CESC cis rs6828523 0.698 rs4695984 chr4:175858796 C/T cg14561282 chr4:175839468 ADAM29 0.46 5.42 0.32 1.32e-7 Breast cancer; CESC cis rs258892 0.895 rs34155124 chr5:72060249 C/T cg21869765 chr5:72125136 TNPO1 -0.43 -5.31 -0.31 2.33e-7 Small cell lung carcinoma; CESC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg19468946 chr17:37922297 IKZF3 -0.39 -5.03 -0.3 9.14e-7 Glomerular filtration rate (creatinine); CESC cis rs17253792 0.822 rs78395034 chr14:56069783 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg24110177 chr3:50126178 RBM5 -0.55 -7.57 -0.42 6.07e-13 Intelligence (multi-trait analysis); CESC cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.09 11.08 0.56 1.09e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12681288 0.862 rs935821 chr8:1022455 G/A cg15309053 chr8:964076 NA 0.34 5.63 0.33 4.59e-8 Schizophrenia; CESC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC cis rs7618501 1.000 rs4855862 chr3:49748833 C/T cg24308560 chr3:49941425 MST1R 0.5 6.94 0.39 3.08e-11 Intelligence (multi-trait analysis); CESC cis rs4566357 0.615 rs4675139 chr2:227908527 G/A cg05526886 chr2:227700861 RHBDD1 -0.45 -5.87 -0.34 1.31e-8 Coronary artery disease; CESC cis rs4722166 0.573 rs35436671 chr7:22775508 G/A cg05472934 chr7:22766657 IL6 0.88 11.05 0.56 1.34e-23 Lung cancer; CESC cis rs2933343 0.729 rs813732 chr3:128619357 C/T cg25356066 chr3:128598488 ACAD9 0.62 8.43 0.46 2.2e-15 IgG glycosylation; CESC cis rs2017305 0.834 rs12252761 chr10:70780296 C/T cg01024728 chr10:70782572 NA 0.57 5.41 0.32 1.4e-7 Depression (quantitative trait); CESC cis rs75804782 0.521 rs55915157 chr2:239424273 T/C cg18131467 chr2:239335373 ASB1 -0.68 -5.54 -0.32 7.3e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs3820068 0.603 rs6668726 chr1:15962614 G/A cg16988262 chr1:15930761 NA 0.34 5.48 0.32 9.82e-8 Systolic blood pressure; CESC cis rs1707322 1.000 rs4660895 chr1:46329739 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06489653 chr2:99061716 INPP4A -0.39 -6.16 -0.35 2.68e-9 Gambling; CESC cis rs1003719 0.715 rs58008706 chr21:38540506 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.7 -0.43 2.7e-13 Eye color traits; CESC cis rs561341 1.000 rs510264 chr17:30323414 A/G cg12193833 chr17:30244370 NA -0.76 -6.95 -0.39 2.87e-11 Hip circumference adjusted for BMI; CESC cis rs1348850 0.914 rs4893944 chr2:178289357 G/T cg23306229 chr2:178417860 TTC30B 0.59 7.51 0.42 8.78e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10197940 0.662 rs10175134 chr2:152299355 G/A cg06191203 chr2:152266755 RIF1 -0.45 -5.34 -0.31 2.02e-7 Lung cancer; CESC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg18337363 chr3:52569053 NT5DC2 0.28 5.05 0.3 8.27e-7 Electroencephalogram traits; CESC cis rs6570726 0.935 rs386823 chr6:145841365 C/T cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.36e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs6594713 0.717 rs8180416 chr5:112868440 A/G cg12552261 chr5:112820674 MCC 0.58 5.7 0.33 3.26e-8 Brain cytoarchitecture; CESC cis rs9611565 0.504 rs5758452 chr22:42144927 G/A cg06634786 chr22:41940651 POLR3H 0.49 5.58 0.32 5.82e-8 Vitiligo; CESC cis rs61008539 0.821 rs10950789 chr7:897492 A/G cg00475322 chr7:917719 C7orf20 0.5 7.39 0.41 1.92e-12 Perceived unattractiveness to mosquitoes; CESC trans rs208520 0.690 rs12208310 chr6:66730108 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.24 0.6 1.32e-27 Exhaled nitric oxide output; CESC cis rs709400 0.633 rs8013101 chr14:103951772 G/C cg12935359 chr14:103987150 CKB -0.51 -7.44 -0.42 1.39e-12 Body mass index; CESC cis rs4555082 0.915 rs28594491 chr14:105758018 G/A cg27165867 chr14:105738592 BRF1 -0.5 -5.38 -0.31 1.68e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg03467027 chr4:99064603 C4orf37 0.42 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3960554 0.808 rs111764601 chr7:75706141 T/C cg17325771 chr7:75508891 RHBDD2 -0.36 -5.37 -0.31 1.72e-7 Eotaxin levels; CESC cis rs4722166 0.603 rs7801406 chr7:22788274 A/G cg05265849 chr7:22767390 IL6 0.56 7.04 0.4 1.62e-11 Lung cancer; CESC trans rs11039798 0.614 rs8188910 chr11:48825740 C/T cg15704280 chr7:45808275 SEPT13 0.7 6.34 0.36 9.71e-10 Axial length; CESC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6582630 0.519 rs10880576 chr12:38497693 T/C cg26384229 chr12:38710491 ALG10B 0.64 9.62 0.51 5.39e-19 Drug-induced liver injury (flucloxacillin); CESC cis rs4835473 0.932 rs4835472 chr4:144903551 A/T cg25736465 chr4:144833511 NA 0.4 6.12 0.35 3.42e-9 Immature fraction of reticulocytes; CESC cis rs9814567 1.000 rs9871305 chr3:134213538 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.99 -0.35 6.73e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs950027 0.620 rs1426932 chr15:45687256 T/C cg21132104 chr15:45694354 SPATA5L1 0.66 8.53 0.46 1.12e-15 Response to fenofibrate (adiponectin levels); CESC cis rs12711979 0.509 rs10200764 chr2:3827772 C/G cg17052675 chr2:3827356 NA -0.67 -11.23 -0.57 3.34e-24 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs9815354 0.812 rs17284472 chr3:41996304 A/G cg03022575 chr3:42003672 ULK4 -0.7 -6.19 -0.36 2.3e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs12545109 0.800 rs1968551 chr8:57407760 T/C cg09654669 chr8:57350985 NA -0.56 -6.65 -0.38 1.67e-10 Obesity-related traits; CESC cis rs9583531 0.600 rs2119479 chr13:111371181 A/C cg15841412 chr13:111365552 ING1 0.52 6.71 0.38 1.19e-10 Coronary artery disease; CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg21548813 chr6:291882 DUSP22 -0.73 -9.72 -0.51 2.63e-19 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16522462 chr20:1875565 SIRPA 0.58 6.66 0.38 1.6e-10 Gut microbiome composition (summer); CESC cis rs61776719 0.747 rs28428561 chr1:38434306 G/A cg18451016 chr1:38461880 NA -0.52 -7.82 -0.43 1.22e-13 Coronary artery disease; CESC cis rs2839186 0.900 rs59828751 chr21:47708918 A/G cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 7.02e-11 Testicular germ cell tumor; CESC cis rs4132509 1.000 rs10927076 chr1:243958293 A/G cg21452805 chr1:244014465 NA 0.49 5.6 0.33 5.46e-8 RR interval (heart rate); CESC cis rs7666738 0.546 rs62320963 chr4:98839297 A/G cg05340658 chr4:99064831 C4orf37 0.54 6.4 0.37 7.1e-10 Colonoscopy-negative controls vs population controls; CESC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg09365446 chr1:150670422 GOLPH3L 0.39 5.21 0.3 3.87e-7 Melanoma; CESC cis rs2230307 0.572 rs514090 chr1:100563186 C/G cg24955406 chr1:100503596 HIAT1 0.53 5.25 0.31 3.18e-7 Carotid intima media thickness; CESC trans rs6677604 1.000 rs12144939 chr1:196698945 G/T cg02859443 chr16:53737878 RPGRIP1L;FTO -0.63 -6.02 -0.35 5.87e-9 IgA nephropathy;Nephropathy;Blood protein levels; CESC cis rs6867032 1.000 rs10462750 chr5:2012963 A/G cg26168224 chr5:2018326 NA 0.91 17.17 0.73 5.99e-45 Gut microbiome composition (winter); CESC cis rs782590 0.967 rs4672054 chr2:55773093 C/A cg18811423 chr2:55921094 PNPT1 0.82 13.34 0.63 2.05e-31 Metabolic syndrome; CESC cis rs2652822 0.525 rs2899691 chr15:63519088 T/A cg02713581 chr15:63449717 RPS27L 0.51 6.49 0.37 4.3e-10 Metabolic traits; CESC cis rs6456156 0.586 rs10946208 chr6:167459596 C/T cg23791538 chr6:167370224 RNASET2 -0.53 -6.84 -0.39 5.4e-11 Primary biliary cholangitis; CESC cis rs7851660 0.506 rs1912996 chr9:100598261 G/T cg13688889 chr9:100608707 NA -0.89 -13.11 -0.63 1.34e-30 Strep throat; CESC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg05564831 chr3:52568323 NT5DC2 -0.47 -7.71 -0.43 2.47e-13 Electroencephalogram traits; CESC cis rs6736093 0.863 rs35757708 chr2:112769902 T/C cg12686935 chr2:112915763 FBLN7 -0.44 -5.66 -0.33 4.03e-8 Coronary artery disease; CESC cis rs4253772 0.832 rs6008259 chr22:46633782 G/A cg24881330 chr22:46731750 TRMU 0.75 8.11 0.45 1.92e-14 LDL cholesterol;Cholesterol, total; CESC cis rs7589728 0.858 rs79992736 chr2:88530575 A/C cg04511125 chr2:88470314 THNSL2 0.61 7.02 0.4 1.81e-11 Plasma clusterin levels; CESC cis rs12893597 0.704 rs34065247 chr14:76834029 A/C cg20290672 chr14:76816747 NA -0.37 -5.24 -0.31 3.36e-7 Maximal oxygen uptake response; CESC cis rs7940866 0.770 rs10750456 chr11:130819634 A/G cg12179176 chr11:130786555 SNX19 0.7 10.51 0.54 7.74e-22 Schizophrenia; CESC cis rs7927771 0.801 rs12798028 chr11:47604639 C/T cg20307385 chr11:47447363 PSMC3 -0.42 -5.23 -0.31 3.38e-7 Subjective well-being; CESC cis rs1018697 0.518 rs284846 chr10:104557290 T/C cg04362960 chr10:104952993 NT5C2 -0.55 -6.24 -0.36 1.77e-9 Colorectal adenoma (advanced); CESC trans rs1814175 0.817 rs1851860 chr11:49861310 A/C cg03929089 chr4:120376271 NA -0.87 -14.03 -0.65 8.19e-34 Height; CESC cis rs8067354 0.872 rs2645466 chr17:57853214 A/C cg13753209 chr17:57696993 CLTC 0.51 6.98 0.39 2.38e-11 Hemoglobin concentration; CESC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg14893161 chr1:205819251 PM20D1 0.87 15.37 0.69 1.47e-38 Menarche (age at onset); CESC cis rs6460942 0.505 rs62448708 chr7:12328450 G/A cg06484146 chr7:12443880 VWDE -0.48 -5.56 -0.32 6.66e-8 Coronary artery disease; CESC cis rs7103648 0.669 rs12577383 chr11:47774238 C/T cg10504702 chr11:47789108 FNBP4 0.43 5.47 0.32 1.03e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs35123781 1.000 rs601324 chr5:139057179 C/G cg10513866 chr5:139070639 NA 0.37 5.37 0.31 1.75e-7 Schizophrenia; CESC trans rs801193 1.000 rs4717310 chr7:66161007 C/T cg26939375 chr7:64535504 NA 0.64 8.67 0.47 4.39e-16 Aortic root size; CESC cis rs4555082 0.834 rs11622165 chr14:105759761 C/A cg06808227 chr14:105710500 BRF1 -0.49 -5.28 -0.31 2.72e-7 Mean platelet volume;Platelet distribution width; CESC cis rs9914988 0.943 rs7215000 chr17:27088436 C/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.29 -0.31 2.56e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg22800045 chr5:56110881 MAP3K1 0.84 10.23 0.53 6.66e-21 Initial pursuit acceleration; CESC cis rs939658 0.728 rs8031638 chr15:79422726 C/T cg17916960 chr15:79447300 NA -0.32 -5.05 -0.3 8.14e-7 Refractive error; CESC cis rs12824058 0.799 rs4759656 chr12:130815804 G/A cg24838063 chr12:130822603 PIWIL1 0.63 8.58 0.47 7.91e-16 Menopause (age at onset); CESC cis rs10845606 1.000 rs10845610 chr12:12839107 G/A cg04607235 chr12:12878440 APOLD1 -0.74 -8.25 -0.45 7.65e-15 Systemic lupus erythematosus; CESC cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg03433033 chr1:76189801 ACADM 0.54 6.3 0.36 1.23e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs17376456 1.000 rs13181660 chr5:93533658 A/G cg21475434 chr5:93447410 FAM172A 0.85 7.64 0.42 4.02e-13 Diabetic retinopathy; CESC cis rs34779708 0.966 rs10827492 chr10:35429825 A/G cg04310649 chr10:35416472 CREM 0.51 6.34 0.36 9.74e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg14820908 chr5:178986412 RUFY1 0.46 7.12 0.4 1.03e-11 Lung cancer; CESC cis rs9902453 0.845 rs12601963 chr17:28246358 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.2 0.45 1.04e-14 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04526987 chr8:131370329 ASAP1 -0.68 -8.34 -0.46 4.07e-15 Gut microbiome composition (summer); CESC cis rs1707322 0.721 rs11211163 chr1:46153548 C/T cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11997175 0.625 rs11777333 chr8:33596470 C/A ch.8.33884649F chr8:33765107 NA 0.51 6.29 0.36 1.34e-9 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03236184 chr10:89621862 PTEN;KILLIN -0.63 -7.37 -0.41 2.21e-12 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs6001185 chr22:39052155 G/A cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.54e-7 Menopause (age at onset); CESC trans rs634534 0.622 rs501353 chr11:65739549 T/G cg17712092 chr4:129076599 LARP1B 0.63 8.49 0.46 1.49e-15 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg25767906 chr1:53392781 SCP2 0.41 5.59 0.32 5.58e-8 Monocyte count; CESC cis rs9902453 0.709 rs6505162 chr17:28444183 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.67 0.43 3.22e-13 Coffee consumption (cups per day); CESC cis rs6665290 0.669 rs3768424 chr1:227177444 A/G cg10327440 chr1:227177885 CDC42BPA -1.13 -25.31 -0.84 1.15e-72 Myeloid white cell count; CESC cis rs9488822 0.676 rs12190737 chr6:116328128 C/A cg26893134 chr6:116381904 FRK 0.25 5.98 0.34 7.06e-9 Cholesterol, total;LDL cholesterol; CESC cis rs7267979 0.966 rs6083855 chr20:25405118 A/G cg08601574 chr20:25228251 PYGB -0.37 -5.43 -0.32 1.25e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg18225595 chr11:63971243 STIP1 -0.45 -5.73 -0.33 2.69e-8 Platelet count; CESC cis rs10206020 0.921 rs9678719 chr2:1549628 A/G cg26248373 chr2:1572462 NA -0.58 -6.59 -0.38 2.38e-10 IgG glycosylation; CESC trans rs11637445 0.677 rs11631864 chr15:68067762 T/C cg14583481 chr3:118865028 C3orf30;IGSF11 -0.41 -6.08 -0.35 4.15e-9 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs3820068 0.705 rs74054769 chr1:15860147 A/C cg18192808 chr1:15853278 DNAJC16 0.48 5.72 0.33 2.8e-8 Systolic blood pressure; CESC cis rs1580019 0.563 rs2392071 chr7:32572536 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.07 17.82 0.74 3.15e-47 Cognitive ability; CESC cis rs763014 0.931 rs3752567 chr16:628130 A/G cg09263875 chr16:632152 PIGQ 0.67 10.99 0.56 2.17e-23 Height; CESC cis rs11098499 0.754 rs714899 chr4:120243035 G/A cg09307838 chr4:120376055 NA 0.8 10.89 0.56 4.48e-23 Corneal astigmatism; CESC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg10792982 chr14:105748885 BRF1 0.42 5.59 0.32 5.74e-8 Mean platelet volume;Platelet distribution width; CESC cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg25517755 chr10:38738941 LOC399744 -0.48 -6.27 -0.36 1.47e-9 Extrinsic epigenetic age acceleration; CESC cis rs35955747 0.934 rs5997966 chr22:31776246 C/T cg25791279 chr22:32026902 PISD -0.49 -5.91 -0.34 1.02e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs2882667 0.824 rs11748097 chr5:138479887 C/A cg04439458 chr5:138467593 SIL1 -0.38 -5.75 -0.33 2.5e-8 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs1814175 0.817 rs1390676 chr11:50056778 C/T cg15704280 chr7:45808275 SEPT13 -1.05 -21.04 -0.79 1.87e-58 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03542721 chr8:22926253 TNFRSF10B 0.52 6.29 0.36 1.32e-9 Gut microbiome composition (summer); CESC cis rs4642101 0.793 rs13086170 chr3:12832604 G/C cg05775895 chr3:12838266 CAND2 0.35 5.3 0.31 2.41e-7 QRS complex (12-leadsum); CESC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg20295408 chr7:1910781 MAD1L1 0.43 5.76 0.33 2.36e-8 Bipolar disorder and schizophrenia; CESC cis rs17384381 0.834 rs11161614 chr1:85898160 A/C cg16011679 chr1:85725395 C1orf52 0.64 7.18 0.4 6.87e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07997682 chr22:41418886 NA -0.46 -6.65 -0.38 1.71e-10 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01249735 chr7:156742241 NOM1 0.57 6.75 0.38 9.13e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13547250 chr16:30107791 YPEL3 0.55 6.43 0.37 5.98e-10 Gut microbiome composition (summer); CESC cis rs7527798 0.592 rs7539772 chr1:207833301 G/A cg21110645 chr1:207815933 NA -0.31 -5.41 -0.32 1.43e-7 Erythrocyte sedimentation rate; CESC cis rs12476592 0.602 rs2421952 chr2:63749833 T/C cg17519650 chr2:63277830 OTX1 -0.49 -5.64 -0.33 4.44e-8 Childhood ear infection; CESC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg05313129 chr8:58192883 C8orf71 0.48 5.26 0.31 2.95e-7 Developmental language disorder (linguistic errors); CESC cis rs12479064 0.724 rs3792150 chr2:100041849 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.7 -0.43 2.79e-13 Chronic sinus infection; CESC cis rs6570726 0.935 rs906774 chr6:145813770 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.72 0.38 1.13e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6032067 0.929 rs17334064 chr20:43839197 T/C cg10761708 chr20:43804764 PI3 0.5 5.91 0.34 1.02e-8 Blood protein levels; CESC cis rs6754311 0.731 rs3769005 chr2:136603366 C/G cg07169764 chr2:136633963 MCM6 -0.68 -8.38 -0.46 3.1e-15 Mosquito bite size; CESC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg03452623 chr4:187889614 NA -0.89 -15.18 -0.68 7.11e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.79 0.43 1.55e-13 Electroencephalogram traits; CESC cis rs6963495 0.556 rs711427 chr7:105161755 T/G cg13798780 chr7:105162888 PUS7 0.51 6.3 0.36 1.26e-9 Bipolar disorder (body mass index interaction); CESC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg12311346 chr5:56204834 C5orf35 -0.83 -10.23 -0.53 6.39e-21 Initial pursuit acceleration; CESC cis rs6800768 1.000 rs6800768 chr3:24113252 T/C cg10674438 chr3:24145617 LOC152024 -0.37 -5.59 -0.33 5.5e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25581932 chr17:7892150 NA 0.56 6.9 0.39 3.83e-11 Gut microbiome composition (summer); CESC cis rs10208940 0.920 rs10211211 chr2:68718191 G/C cg12452813 chr2:68675892 NA 0.52 5.24 0.31 3.26e-7 Urate levels in lean individuals; CESC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg19717773 chr7:2847554 GNA12 -0.56 -7.86 -0.43 9.86e-14 Height; CESC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg03806693 chr22:41940476 POLR3H -1.22 -15.27 -0.68 3.46e-38 Vitiligo; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00318242 chr5:137548698 CDC23 0.47 6.4 0.37 7.14e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9660180 0.967 rs61422524 chr1:1767565 C/A cg23982607 chr1:1823379 GNB1 -0.76 -12.08 -0.6 4.49e-27 Body mass index; CESC cis rs561341 0.941 rs2470236 chr17:30304940 G/C cg19193384 chr17:30244184 NA -0.6 -6.35 -0.36 9.57e-10 Hip circumference adjusted for BMI; CESC cis rs963731 0.579 rs10190377 chr2:39250673 A/G cg04010122 chr2:39346883 SOS1 -0.58 -5.17 -0.3 4.53e-7 Corticobasal degeneration; CESC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg22920501 chr2:26401640 FAM59B -0.9 -10.21 -0.53 7.46e-21 Gut microbiome composition (summer); CESC cis rs710216 0.843 rs10890232 chr1:43416514 C/T cg03128534 chr1:43423976 SLC2A1 0.61 7.74 0.43 2.04e-13 Red cell distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12855988 chr6:133135904 RPS12;SNORD101 0.53 6.26 0.36 1.58e-9 Gut microbiome composition (summer); CESC cis rs2502731 0.539 rs3003610 chr9:130985525 G/A cg09976142 chr9:130955436 CIZ1 0.41 6.63 0.38 1.83e-10 Attention deficit hyperactivity disorder; CESC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25509121 chr17:61851092 DDX42;CCDC47 -0.47 -6.38 -0.36 7.93e-10 Gut microbiota (bacterial taxa); CESC cis rs6582630 0.502 rs10880450 chr12:38440294 G/C cg13010199 chr12:38710504 ALG10B 0.43 5.57 0.32 6.34e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs4718428 0.705 rs3800817 chr7:66263550 T/A cg12165864 chr7:66369176 NA -0.64 -7.35 -0.41 2.39e-12 Corneal structure; CESC cis rs752010 0.841 rs58737163 chr1:42079821 G/T cg06885757 chr1:42089581 HIVEP3 0.47 7.63 0.42 4.22e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg18876405 chr7:65276391 NA 0.47 6.29 0.36 1.27e-9 Aortic root size; CESC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg08736216 chr1:53307985 ZYG11A -0.41 -6.69 -0.38 1.34e-10 Monocyte count; CESC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.94 0.59 1.43e-26 Alzheimer's disease; CESC cis rs1348850 0.914 rs4893938 chr2:178250095 T/C cg23306229 chr2:178417860 TTC30B 0.64 8.26 0.45 7.09e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs290268 0.845 rs290266 chr9:93537952 T/A cg02608019 chr9:93564028 SYK 0.57 8.39 0.46 2.91e-15 Platelet count; CESC cis rs2050392 0.624 rs303447 chr10:30728464 T/C cg02070205 chr10:30722105 MAP3K8 -0.46 -5.42 -0.32 1.33e-7 Inflammatory bowel disease; CESC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.33 0.31 2.11e-7 Tonsillectomy; CESC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg15445000 chr17:37608096 MED1 -0.4 -6.39 -0.37 7.58e-10 Glomerular filtration rate (creatinine); CESC cis rs11583043 0.874 rs41312668 chr1:101443582 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 5.51 0.32 8.64e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs1949733 0.523 rs16842563 chr4:8545146 C/T cg11789530 chr4:8429930 ACOX3 -0.52 -6.79 -0.38 7.45e-11 Response to antineoplastic agents; CESC cis rs7520050 0.751 rs2991975 chr1:46024526 A/G cg24296786 chr1:45957014 TESK2 0.5 6.33 0.36 1.03e-9 Red blood cell count;Reticulocyte count; CESC cis rs3020736 0.500 rs6002605 chr22:42494335 A/G cg15557168 chr22:42548783 NA 0.45 6.35 0.36 9.09e-10 Autism spectrum disorder or schizophrenia; CESC cis rs453301 0.571 rs2929452 chr8:9084465 G/A cg17143192 chr8:8559678 CLDN23 -0.46 -5.65 -0.33 4.11e-8 Joint mobility (Beighton score); CESC cis rs8062405 1.000 rs62036622 chr16:28837203 T/G cg05966235 chr16:28915196 ATP2A1 0.35 5.09 0.3 6.75e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs16867321 0.950 rs9677293 chr2:181499459 C/G cg23363182 chr2:181467187 NA -0.43 -5.69 -0.33 3.39e-8 Obesity; CESC trans rs2898290 0.622 rs4840567 chr8:11347625 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -6.03 -0.35 5.53e-9 Systolic blood pressure; CESC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg24549020 chr5:56110836 MAP3K1 0.68 7.72 0.43 2.37e-13 Initial pursuit acceleration; CESC cis rs57221529 0.709 rs4957056 chr5:570105 T/C cg09021430 chr5:549028 NA -0.42 -5.08 -0.3 7.04e-7 Lung disease severity in cystic fibrosis; CESC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.14 -0.3 5.22e-7 Lung cancer; CESC cis rs959260 1.000 rs2117562 chr17:73369000 C/T cg20590849 chr17:73267439 MIF4GD -0.54 -6.32 -0.36 1.13e-9 Systemic lupus erythematosus; CESC cis rs16854884 0.739 rs1075113 chr3:143760535 C/T cg06585982 chr3:143692056 C3orf58 0.49 6.3 0.36 1.23e-9 Economic and political preferences (feminism/equality); CESC cis rs4268898 0.571 rs1986478 chr2:24468545 G/A cg06627628 chr2:24431161 ITSN2 -0.97 -11.05 -0.56 1.32e-23 Asthma; CESC cis rs6121246 0.567 rs6060262 chr20:30193071 A/C cg13852791 chr20:30311386 BCL2L1 0.67 6.71 0.38 1.2e-10 Mean corpuscular hemoglobin; CESC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 5.8 0.34 1.84e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24993015 chr5:37371179 NUP155 0.58 6.56 0.37 2.74e-10 Gut microbiome composition (summer); CESC cis rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09249682 chr7:17338253 AHR -0.41 -5.3 -0.31 2.5e-7 Fibrinogen levels; CESC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.82 10.4 0.54 1.81e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10791097 0.967 rs1944142 chr11:130717440 C/T cg14779329 chr11:130786720 SNX19 0.34 5.3 0.31 2.42e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4843747 0.671 rs72818540 chr16:88078988 C/T cg17633681 chr16:88106987 BANP 0.71 9.32 0.5 4.59e-18 Menopause (age at onset); CESC cis rs17021463 0.676 rs11097421 chr4:95302915 T/C cg11021082 chr4:95130006 SMARCAD1 0.52 7.21 0.4 5.93e-12 Testicular germ cell tumor; CESC cis rs12048904 0.964 rs12027668 chr1:101330984 G/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.52 6.61 0.38 2.11e-10 Multiple sclerosis; CESC cis rs6460942 0.505 rs73290446 chr7:12358133 T/G cg20607287 chr7:12443886 VWDE -0.57 -6.12 -0.35 3.31e-9 Coronary artery disease; CESC cis rs12464559 0.522 rs7583060 chr2:152620943 C/A cg01189475 chr2:152685088 ARL5A 0.7 6.72 0.38 1.13e-10 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs2732480 0.537 rs1061986 chr12:48736439 T/C cg24011408 chr12:48396354 COL2A1 0.44 5.95 0.34 8.54e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs10883723 0.810 rs13287 chr10:104240438 A/G cg22532475 chr10:104410764 TRIM8 -0.32 -5.35 -0.31 1.89e-7 Allergic disease (asthma, hay fever or eczema); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg00024472 chr17:47573864 NGFR 0.48 6.11 0.35 3.58e-9 Psoriatic arthritis; CESC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg12463550 chr7:65579703 CRCP -0.53 -6.87 -0.39 4.46e-11 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16529530 chr1:32688001 EIF3I;C1orf91 0.6 6.61 0.38 2.13e-10 Gut microbiome composition (summer); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg13483984 chr1:224580455 WDR26 0.4 6.04 0.35 5.06e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2242116 0.796 rs4683296 chr3:46973820 G/C cg02527881 chr3:46936655 PTH1R 0.52 7.3 0.41 3.29e-12 Birth weight; CESC cis rs1008375 1.000 rs10939750 chr4:17692422 C/G cg02297831 chr4:17616191 MED28 0.48 5.86 0.34 1.4e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs17253792 0.822 rs2274075 chr14:56096731 A/G cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs1387259 0.570 rs12368659 chr12:48562299 C/A cg04545296 chr12:48745243 ZNF641 0.35 6.02 0.35 5.83e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg26338869 chr17:61819248 STRADA 0.73 9.52 0.5 1.11e-18 Prudent dietary pattern; CESC cis rs1797885 0.934 rs299658 chr3:12552084 A/G cg26432171 chr3:12704882 RAF1 -0.46 -5.63 -0.33 4.52e-8 Immature fraction of reticulocytes; CESC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.76 10.89 0.56 4.42e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg11890956 chr21:40555474 PSMG1 -0.93 -15.1 -0.68 1.32e-37 Cognitive function; CESC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg13395646 chr4:1353034 KIAA1530 -0.38 -5.07 -0.3 7.66e-7 Longevity; CESC trans rs8007846 0.569 rs4400971 chr14:66254578 A/C cg24965984 chr10:113943723 GPAM 0.43 6.16 0.35 2.65e-9 Multiple sclerosis--Brain Glutamate Levels; CESC cis rs9910055 0.615 rs189049 chr17:42197213 A/C cg19774624 chr17:42201019 HDAC5 0.86 13.63 0.64 2.1e-32 Total body bone mineral density; CESC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg27170947 chr2:26402098 FAM59B -0.59 -7.11 -0.4 1.1e-11 Gut microbiome composition (summer); CESC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg03806693 chr22:41940476 POLR3H 1.19 14.41 0.66 3.63e-35 Vitiligo; CESC cis rs10129255 0.912 rs35468694 chr14:107192436 A/C cg07958169 chr14:107095056 NA -0.4 -5.5 -0.32 8.83e-8 Kawasaki disease; CESC cis rs1878931 0.697 rs1044390 chr16:3432594 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 1.07 18.3 0.75 6.4e-49 Body mass index (adult); CESC trans rs11113894 0.579 rs11113845 chr12:108778298 A/G cg24376434 chr1:170634859 PRRX1 -0.87 -6.61 -0.38 2.11e-10 Obesity-related traits; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg02683314 chr19:4182606 SIRT6;ANKRD24 -0.41 -6.0 -0.35 6.49e-9 Breast cancer; CESC cis rs12477438 0.834 rs1563107 chr2:99701276 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.7 9.34 0.5 4.2e-18 Chronic sinus infection; CESC cis rs8072100 0.840 rs9893901 chr17:45506682 T/G cg25173405 chr17:45401733 C17orf57 -0.41 -5.44 -0.32 1.21e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs250677 0.687 rs250663 chr5:148453117 T/C cg18129178 chr5:148520854 ABLIM3 -0.5 -5.77 -0.33 2.22e-8 Breast cancer; CESC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg09033563 chr22:24373618 LOC391322 0.52 5.93 0.34 9.44e-9 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs11098499 0.955 rs13114751 chr4:120156617 G/A cg09307838 chr4:120376055 NA 0.87 11.45 0.58 6.04e-25 Corneal astigmatism; CESC cis rs4481887 1.000 rs6683717 chr1:248476792 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.66 0.38 1.54e-10 Common traits (Other); CESC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.31e-9 Developmental language disorder (linguistic errors); CESC cis rs2737618 0.630 rs2821328 chr1:200082051 G/A cg21825944 chr1:200113062 NR5A2 -0.47 -7.17 -0.4 7.64e-12 Uric acid levels; CESC trans rs1545843 0.564 rs1459612 chr12:84890302 C/T cg03015433 chr16:56623111 MT3 0.33 6.01 0.35 6.09e-9 Major depressive disorder; CESC cis rs9992101 0.547 rs7654754 chr4:77409795 C/T cg20311846 chr4:77356250 SHROOM3 -0.26 -5.11 -0.3 6.1e-7 Creatinine levels; CESC trans rs634534 0.562 rs661335 chr11:65754061 G/A cg17712092 chr4:129076599 LARP1B 0.72 9.89 0.52 7.93e-20 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs9811920 0.609 rs4479633 chr3:99654510 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.59 -7.22 -0.41 5.61e-12 Axial length; CESC cis rs7202877 0.611 rs56092808 chr16:75312716 A/T cg04384234 chr16:75411784 CFDP1 -0.45 -5.23 -0.31 3.42e-7 Type 2 diabetes;Type 1 diabetes; CESC trans rs7246657 0.882 rs13345148 chr19:37819631 A/G cg24637308 chr11:6592297 DNHD1 0.53 6.15 0.35 2.8e-9 Coronary artery calcification; CESC cis rs1050631 1.000 rs1050631 chr18:33694120 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 -0.41 -5.41 -0.32 1.42e-7 Esophageal squamous cell cancer (length of survival); CESC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg26939375 chr7:64535504 NA -0.77 -10.9 -0.56 4.36e-23 Aortic root size; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg18887839 chr14:67894263 NA 0.45 6.25 0.36 1.64e-9 Thyroid stimulating hormone; CESC cis rs17253792 0.822 rs17832365 chr14:56153531 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.73 0.33 2.74e-8 Putamen volume; CESC cis rs6754311 0.773 rs309180 chr2:136614255 A/G cg15123519 chr2:136567270 LCT -0.3 -5.15 -0.3 5.02e-7 Mosquito bite size; CESC cis rs3806843 0.932 rs2563257 chr5:140140529 A/G cg26395211 chr5:140044315 WDR55 0.39 5.17 0.3 4.51e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7044106 0.762 rs4837790 chr9:123446325 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.83 0.34 1.58e-8 Hip circumference adjusted for BMI; CESC cis rs7605827 0.897 rs13010658 chr2:15668468 A/G cg19274914 chr2:15703543 NA 0.33 5.8 0.34 1.88e-8 Educational attainment (years of education); CESC cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg25019033 chr10:957182 NA -0.57 -6.13 -0.35 3.19e-9 Eosinophil percentage of granulocytes; CESC cis rs936229 0.749 rs4886633 chr15:75178207 G/A cg14664628 chr15:75095509 CSK -0.72 -9.05 -0.49 3.28e-17 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg24549020 chr5:56110836 MAP3K1 -0.4 -5.03 -0.3 9.19e-7 Initial pursuit acceleration; CESC cis rs28386778 0.965 rs2854154 chr17:61981696 C/A cg06873352 chr17:61820015 STRADA -0.68 -11.53 -0.58 3.38e-25 Prudent dietary pattern; CESC cis rs7917772 0.503 rs7899576 chr10:104307504 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.93 -0.34 9.49e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs734999 0.572 rs2985857 chr1:2532624 C/T cg18854424 chr1:2615690 NA -0.27 -5.19 -0.3 4.11e-7 Ulcerative colitis; CESC trans rs3749237 0.964 rs34522271 chr3:49808517 A/G cg21659725 chr3:3221576 CRBN 0.53 6.28 0.36 1.39e-9 Resting heart rate; CESC cis rs12477438 0.765 rs2278895 chr2:99613484 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.09 11.83 0.59 3.18e-26 Gut microbiome composition (summer); CESC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg21770322 chr7:97807741 LMTK2 0.58 8.5 0.46 1.36e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.03 0.4 1.78e-11 Height; CESC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -7.2 -0.4 6.36e-12 Personality dimensions; CESC cis rs35272691 1 rs35272691 chr17:38157841 T/C cg17467752 chr17:38218738 THRA -0.45 -5.94 -0.34 9.08e-9 White blood cell count (neutrophil); CESC cis rs3857067 0.806 rs17374832 chr4:95114394 G/A cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg16405210 chr4:1374714 KIAA1530 -0.91 -12.03 -0.59 6.78e-27 Longevity; CESC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg17949981 chr6:28129498 ZNF389 0.43 5.69 0.33 3.43e-8 Depression; CESC cis rs6982240 0.569 rs6992286 chr8:142279412 G/A cg27411547 chr8:142287226 NA -0.55 -7.99 -0.44 4.17e-14 Tonsillectomy; CESC cis rs7527798 0.592 rs12563520 chr1:207844062 C/T cg21110645 chr1:207815933 NA -0.33 -5.75 -0.33 2.4e-8 Erythrocyte sedimentation rate; CESC cis rs7917772 0.503 rs11191342 chr10:104344450 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.47 0.42 1.15e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6690583 0.562 rs76839162 chr1:85530021 A/G cg22488158 chr1:85528044 WDR63 0.55 5.26 0.31 3.03e-7 Serum sulfate level; CESC cis rs4790333 0.813 rs2005029 chr17:2255138 G/T cg02569219 chr17:2266849 SGSM2 -0.39 -5.12 -0.3 5.98e-7 Proinsulin levels; CESC cis rs73206853 0.764 rs28840785 chr12:110844920 C/G cg12870014 chr12:110450643 ANKRD13A 0.63 5.18 0.3 4.34e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs360798 0.532 rs7573756 chr2:62990637 G/A cg17519650 chr2:63277830 OTX1 -0.59 -7.61 -0.42 4.72e-13 Coronary artery disease; CESC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs672059 0.548 rs500530 chr1:183254972 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.5 -5.91 -0.34 1.02e-8 Hypertriglyceridemia; CESC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg15369054 chr17:80825471 TBCD 0.47 5.2 0.3 3.98e-7 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.55 0.64 3.99e-32 Prudent dietary pattern; CESC cis rs698833 0.886 rs2927433 chr2:44580737 T/A cg04920474 chr2:44395004 PPM1B 0.37 5.04 0.3 8.75e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg11764359 chr7:65958608 NA -0.73 -9.1 -0.49 2.27e-17 Aortic root size; CESC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg13628971 chr7:2884303 GNA12 0.62 7.94 0.44 5.91e-14 Height; CESC cis rs2243480 0.901 rs778687 chr7:65835819 G/A cg18252515 chr7:66147081 NA -1.39 -14.18 -0.66 2.5e-34 Diabetic kidney disease; CESC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12220238 1.000 rs12357530 chr10:75928654 C/A cg19889307 chr10:75911429 ADK;AP3M1 0.63 6.1 0.35 3.78e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs17376456 0.825 rs13361613 chr5:93272176 C/T cg21475434 chr5:93447410 FAM172A 0.74 6.16 0.35 2.67e-9 Diabetic retinopathy; CESC cis rs116095464 0.558 rs10036253 chr5:238519 A/C cg20965017 chr5:231967 SDHA -0.47 -5.3 -0.31 2.49e-7 Breast cancer; CESC cis rs7116495 0.609 rs10751191 chr11:71680920 C/T cg18441811 chr11:71824068 C11orf51 -0.81 -5.3 -0.31 2.48e-7 Severe influenza A (H1N1) infection; CESC cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg00745463 chr17:30367425 LRRC37B -0.81 -7.35 -0.41 2.5e-12 Hip circumference adjusted for BMI; CESC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg21535942 chr1:75199100 CRYZ;TYW3 0.4 5.23 0.31 3.46e-7 Resistin levels; CESC cis rs77741769 0.529 rs3213572 chr12:121205078 A/G cg02419362 chr12:121203948 SPPL3 -0.35 -5.77 -0.33 2.18e-8 Mean corpuscular volume; CESC cis rs977987 0.843 rs8056080 chr16:75410798 C/A cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.78e-8 Dupuytren's disease; CESC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg04267008 chr7:1944627 MAD1L1 -0.53 -6.25 -0.36 1.61e-9 Schizophrenia; CESC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22271113 chr17:8370397 NDEL1 0.51 7.13 0.4 9.42e-12 Fibrinogen levels; CESC cis rs9479482 1.000 rs11754987 chr6:150351204 G/A cg03788504 chr6:150331562 NA -0.38 -7.07 -0.4 1.38e-11 Alopecia areata; CESC cis rs6456156 0.586 rs7746628 chr6:167483235 A/G cg23791538 chr6:167370224 RNASET2 -0.51 -6.44 -0.37 5.67e-10 Primary biliary cholangitis; CESC cis rs9858542 0.953 rs35169793 chr3:49423274 A/G cg03060546 chr3:49711283 APEH -0.54 -6.16 -0.35 2.67e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4132509 1.000 rs4553169 chr1:243900640 G/A cg21452805 chr1:244014465 NA 0.42 5.36 0.31 1.85e-7 RR interval (heart rate); CESC cis rs941873 0.836 rs6480931 chr10:81108482 T/C cg11057378 chr10:81107060 PPIF 0.35 5.57 0.32 6.2e-8 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24625240 chr11:126081434 RPUSD4;FAM118B -0.45 -6.91 -0.39 3.61e-11 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05099121 chr7:91764089 CYP51A1 0.51 6.09 0.35 3.99e-9 Gut microbiome composition (summer); CESC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg10792982 chr14:105748885 BRF1 0.42 5.54 0.32 7.27e-8 Mean platelet volume;Platelet distribution width; CESC trans rs2216164 0.933 rs2080414 chr12:68571817 A/T cg27495728 chr7:99067116 NA -0.35 -6.26 -0.36 1.56e-9 Alopecia areata; CESC trans rs801193 1.000 rs2003301 chr7:66147656 G/C cg26939375 chr7:64535504 NA -0.63 -8.5 -0.46 1.4e-15 Aortic root size; CESC cis rs6087990 0.899 rs6087999 chr20:31363774 A/G cg13636640 chr20:31349939 DNMT3B 0.9 16.5 0.71 1.5e-42 Ulcerative colitis; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg21289763 chr17:78868835 RPTOR 0.41 6.01 0.35 6.22e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs75575287 1.000 rs17120196 chr14:73206034 C/T cg14758526 chr11:104879683 CASP5 -0.84 -6.06 -0.35 4.57e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs111326718 1 rs111326718 chr10:104771211 A/AAAAAT cg08650961 chr10:104748594 CNNM2 0.33 5.5 0.32 8.73e-8 Reticulocyte count; CESC cis rs193541 0.642 rs42538 chr5:122292352 A/T cg19412675 chr5:122181750 SNX24 0.45 5.34 0.31 2.03e-7 Glucose homeostasis traits; CESC cis rs2235544 0.565 rs7513522 chr1:54465705 A/G cg25741118 chr1:54482237 LDLRAD1 0.23 5.65 0.33 4.13e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21745091 chr11:118992183 HINFP -0.44 -6.06 -0.35 4.7e-9 Fibrinogen levels; CESC cis rs483180 0.512 rs606312 chr1:120222582 G/A cg19096424 chr1:120255104 PHGDH 0.44 5.35 0.31 1.92e-7 Macular telangiectasia type 2; CESC cis rs3820928 0.874 rs10210963 chr2:227821845 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -5.58 -0.32 5.9e-8 Pulmonary function; CESC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg04267008 chr7:1944627 MAD1L1 -0.6 -7.33 -0.41 2.73e-12 Bipolar disorder and schizophrenia; CESC cis rs7551222 0.752 rs12566957 chr1:204556958 C/T cg20240347 chr1:204465584 NA -0.29 -5.95 -0.34 8.64e-9 Schizophrenia; CESC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg09877947 chr5:131593287 PDLIM4 0.48 6.32 0.36 1.11e-9 Acylcarnitine levels; CESC cis rs826838 0.684 rs12367400 chr12:38618673 G/T cg26384229 chr12:38710491 ALG10B 0.74 11.21 0.57 3.91e-24 Heart rate; CESC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7927592 0.763 rs596494 chr11:68251054 T/G cg20283391 chr11:68216788 NA -0.47 -5.99 -0.35 6.92e-9 Total body bone mineral density; CESC trans rs11098499 0.754 rs1546503 chr4:120241167 T/C cg25214090 chr10:38739885 LOC399744 0.61 8.49 0.46 1.47e-15 Corneal astigmatism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15380607 chr6:138188545 TNFAIP3 -0.5 -6.45 -0.37 5.17e-10 Ulcerative colitis; CESC cis rs2932538 0.961 rs3013441 chr1:113192605 C/T cg22162597 chr1:113214053 CAPZA1 -0.55 -6.7 -0.38 1.24e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs763121 0.853 rs2284073 chr22:39105948 T/C cg06022373 chr22:39101656 GTPBP1 0.95 18.16 0.74 1.96e-48 Menopause (age at onset); CESC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg10691866 chr7:65817282 TPST1 -0.31 -5.08 -0.3 7.3e-7 Aortic root size; CESC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg11890956 chr21:40555474 PSMG1 -0.69 -9.95 -0.52 5.08e-20 Menarche (age at onset); CESC cis rs34330 0.562 rs7486387 chr12:12866911 G/A cg04607235 chr12:12878440 APOLD1 -0.76 -8.34 -0.46 4.15e-15 Systemic lupus erythematosus; CESC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg17143192 chr8:8559678 CLDN23 0.73 8.7 0.47 3.55e-16 Obesity-related traits; CESC trans rs11098499 0.954 rs13133522 chr4:120324424 A/T cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg22143856 chr6:28129313 ZNF389 0.43 5.34 0.31 2.03e-7 Parkinson's disease; CESC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.54 0.54 6.46e-22 Prudent dietary pattern; CESC cis rs9916302 0.904 rs1619021 chr17:37739274 G/A cg15445000 chr17:37608096 MED1 0.39 6.05 0.35 4.91e-9 Glomerular filtration rate (creatinine); CESC cis rs7267979 1.000 rs2424700 chr20:25266513 A/G cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.05e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs367615 0.918 rs10055528 chr5:108861129 G/T cg17395555 chr5:108820864 NA 0.54 7.88 0.44 8.68e-14 Colorectal cancer (SNP x SNP interaction); CESC cis rs854765 0.583 rs7503334 chr17:17779458 C/T cg09796270 chr17:17721594 SREBF1 -0.46 -6.46 -0.37 4.99e-10 Total body bone mineral density; CESC cis rs4664304 0.966 rs925411 chr2:160745785 G/T cg03641300 chr2:160917029 PLA2R1 -0.49 -6.99 -0.39 2.24e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs561341 1.000 rs542132 chr17:30307193 A/T cg23018236 chr17:30244563 NA -0.52 -5.1 -0.3 6.39e-7 Hip circumference adjusted for BMI; CESC cis rs4253772 0.515 rs8142080 chr22:46647429 G/T cg10541313 chr22:46663664 TTC38 0.73 5.69 0.33 3.36e-8 LDL cholesterol;Cholesterol, total; CESC trans rs4332037 0.950 rs11771828 chr7:1941003 T/C cg11693508 chr17:37793320 STARD3 0.67 6.4 0.37 6.96e-10 Bipolar disorder; CESC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.69 -9.14 -0.49 1.63e-17 Total body bone mineral density; CESC cis rs2933343 0.700 rs1683787 chr3:128627021 C/T cg25356066 chr3:128598488 ACAD9 -0.58 -8.19 -0.45 1.14e-14 IgG glycosylation; CESC cis rs3960554 0.600 rs2302429 chr7:75614777 G/A cg03214087 chr7:75624699 TMEM120A -0.37 -5.47 -0.32 1.02e-7 Eotaxin levels; CESC cis rs9355610 0.892 rs2247314 chr6:167370230 T/C cg25258033 chr6:167368657 RNASET2 -0.4 -5.87 -0.34 1.27e-8 Graves' disease; CESC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg06600287 chr1:53387719 ECHDC2 -0.27 -5.05 -0.3 8.13e-7 Monocyte count; CESC trans rs801193 0.613 rs2016325 chr7:66323500 T/C cg18876405 chr7:65276391 NA -0.59 -7.53 -0.42 7.76e-13 Aortic root size; CESC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg12463550 chr7:65579703 CRCP -0.52 -6.63 -0.38 1.84e-10 Aortic root size; CESC cis rs568617 1.000 rs641018 chr11:65655393 G/C cg19792802 chr11:65647270 CTSW 0.36 5.44 0.32 1.24e-7 Crohn's disease; CESC trans rs2018683 0.707 rs4722875 chr7:28969632 A/G cg19402173 chr7:128379420 CALU -0.51 -6.84 -0.39 5.62e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs2820292 1.000 rs2494112 chr1:201787833 G/A cg11586189 chr1:201857591 SHISA4 0.32 5.32 0.31 2.25e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs4474465 0.541 rs11237527 chr11:78219664 C/A cg27205649 chr11:78285834 NARS2 0.44 5.28 0.31 2.69e-7 Alzheimer's disease (survival time); CESC cis rs9486715 1.000 rs9373985 chr6:97063522 C/G cg06623918 chr6:96969491 KIAA0776 -0.88 -13.15 -0.63 9.55e-31 Headache; CESC cis rs1009170 0.522 rs8004117 chr14:92638468 A/G ch.14.1475328F chr14:92585817 NDUFB1 0.44 5.06 0.3 7.88e-7 Dialysis-related mortality; CESC cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg11752832 chr7:134001865 SLC35B4 0.49 5.84 0.34 1.56e-8 Mean platelet volume; CESC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg23161317 chr6:28129485 ZNF389 0.49 6.14 0.35 3.02e-9 Parkinson's disease; CESC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg15038512 chr6:170123185 PHF10 0.45 6.07 0.35 4.44e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9908102 0.710 rs4792313 chr17:12918296 T/C cg26162695 chr17:12921313 ELAC2 0.56 6.04 0.35 5.13e-9 Schizophrenia; CESC cis rs7131987 0.903 rs10843371 chr12:29414232 G/A cg09582351 chr12:29534625 ERGIC2 -0.35 -5.59 -0.32 5.57e-8 QT interval; CESC cis rs2154427 0.938 rs114440021 chr21:34202672 C/T cg21871883 chr21:34145043 C21orf49;C21orf66 0.62 5.15 0.3 5.15e-7 Bilirubin levels; CESC trans rs6089829 0.851 rs6122346 chr20:61661822 C/G cg23505145 chr19:12996616 KLF1 0.52 6.7 0.38 1.24e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg17971929 chr21:40555470 PSMG1 1.04 16.44 0.71 2.36e-42 Cognitive function; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01522446 chr17:41150340 RPL27 0.49 6.83 0.39 5.93e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg17143192 chr8:8559678 CLDN23 -0.7 -7.81 -0.43 1.3e-13 Obesity-related traits; CESC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg24531977 chr5:56204891 C5orf35 -0.89 -11.1 -0.56 9.12e-24 Initial pursuit acceleration; CESC cis rs1728785 1.000 rs1728773 chr16:68563644 A/C cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs7560272 0.723 rs6722867 chr2:73816285 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -7.03 -0.4 1.74e-11 Schizophrenia; CESC cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg17366294 chr4:99064904 C4orf37 0.57 7.86 0.43 9.47e-14 Colonoscopy-negative controls vs population controls; CESC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg05518939 chr3:121554459 IQCB1;EAF2 -0.45 -6.7 -0.38 1.21e-10 Response to TNF-alpha inhibitors in rheumatoid arthritis; CESC cis rs2797160 1.000 rs1739373 chr6:126011509 A/G cg05901451 chr6:126070800 HEY2 0.45 6.62 0.38 2e-10 Endometrial cancer; CESC cis rs17376456 0.877 rs12374470 chr5:93481046 A/G cg21475434 chr5:93447410 FAM172A 0.88 7.64 0.42 3.98e-13 Diabetic retinopathy; CESC cis rs2832077 0.506 rs10222093 chr21:30163518 T/C cg24692254 chr21:30365293 RNF160 -0.51 -6.02 -0.35 5.92e-9 Cognitive test performance; CESC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg19717773 chr7:2847554 GNA12 -0.54 -7.66 -0.43 3.55e-13 Height; CESC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs838147 0.507 rs1704773 chr19:49209566 A/G cg21064579 chr19:49206444 FUT2 0.51 7.12 0.4 9.95e-12 Dietary macronutrient intake; CESC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.48 -0.54 9.87e-22 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25907362 chr10:120937749 PRDX3 -0.63 -6.85 -0.39 5.25e-11 Gut microbiome composition (summer); CESC cis rs62229266 0.804 rs62230821 chr21:37425116 C/T cg12218747 chr21:37451666 NA -0.42 -5.88 -0.34 1.23e-8 Mitral valve prolapse; CESC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg18404041 chr3:52824283 ITIH1 -0.37 -6.26 -0.36 1.54e-9 Electroencephalogram traits; CESC cis rs372883 0.638 rs371432 chr21:30710876 G/A cg24692254 chr21:30365293 RNF160 -0.52 -6.55 -0.37 2.97e-10 Pancreatic cancer; CESC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg11247378 chr22:39784982 NA -0.59 -9.03 -0.49 3.52e-17 Intelligence (multi-trait analysis); CESC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.7 -8.01 -0.44 3.69e-14 Gut microbiome composition (summer); CESC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg04944784 chr2:26401820 FAM59B 0.94 10.66 0.55 2.64e-22 Gut microbiome composition (summer); CESC trans rs1994135 0.565 rs1905240 chr12:33645009 A/G cg26384229 chr12:38710491 ALG10B -0.46 -6.28 -0.36 1.35e-9 Resting heart rate; CESC cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg22875332 chr1:76189707 ACADM 0.69 9.24 0.49 8.13e-18 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08798701 chr3:129118382 RPL32P3 -0.55 -6.27 -0.36 1.43e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.729 rs169362 chr22:41827589 G/C cg06634786 chr22:41940651 POLR3H 0.44 5.15 0.3 5.05e-7 Vitiligo; CESC trans rs6543990 0.741 rs305191 chr2:36252564 C/T cg04092111 chr11:58728533 NA -0.41 -6.02 -0.35 5.87e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2651899 0.902 rs2742673 chr1:3080019 A/C cg07622451 chr1:3079886 PRDM16 -0.31 -5.63 -0.33 4.51e-8 Migraine; CESC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg08888203 chr3:10149979 C3orf24 0.48 6.09 0.35 3.99e-9 Alzheimer's disease; CESC cis rs4820294 1.000 rs732856 chr22:38060691 C/G cg21798802 chr22:38057573 PDXP -0.46 -7.88 -0.44 8.53e-14 Fat distribution (HIV); CESC cis rs6691722 1.000 rs6691722 chr1:24673866 A/G cg02336364 chr1:24764700 NIPAL3 0.26 5.1 0.3 6.47e-7 Response to interferon beta in multiple sclerosis; CESC cis rs3096299 0.566 rs4129126 chr16:89561475 A/C cg02187348 chr16:89574699 SPG7 0.49 6.13 0.35 3.11e-9 Multiple myeloma (IgH translocation); CESC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.21 0.3 3.85e-7 Bipolar disorder; CESC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg25072359 chr17:41440525 NA 0.5 6.75 0.38 9.44e-11 Menopause (age at onset); CESC cis rs4595586 0.545 rs7972590 chr12:39376615 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs920590 0.684 rs57837509 chr8:19670088 A/G cg17834443 chr8:19674713 INTS10 0.59 6.57 0.37 2.69e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg24060327 chr5:131705240 SLC22A5 0.7 9.59 0.51 7.1e-19 Blood metabolite levels; CESC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg17372223 chr3:52568218 NT5DC2 0.44 6.63 0.38 1.88e-10 Bipolar disorder; CESC cis rs548181 0.577 rs569766 chr11:125532369 G/A cg03464685 chr11:125439445 EI24 0.89 7.67 0.43 3.32e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg09323728 chr8:95962352 TP53INP1 -0.42 -9.2 -0.49 1.09e-17 Type 2 diabetes; CESC trans rs7617773 0.780 rs3731550 chr3:48206583 A/C cg02094337 chr17:80542118 FOXK2 0.43 6.16 0.35 2.63e-9 Coronary artery disease; CESC cis rs12765878 1.000 rs10883943 chr10:105651416 G/T cg11005552 chr10:105648138 OBFC1 0.34 5.05 0.3 8.35e-7 Coronary artery disease; CESC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg14703610 chr5:56206110 C5orf35 0.48 5.96 0.34 7.88e-9 Coronary artery disease; CESC cis rs950776 0.518 rs11636131 chr15:78821606 C/T cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.23 0.31 3.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg23283495 chr1:209979779 IRF6 0.51 7.55 0.42 6.94e-13 Cleft lip with or without cleft palate; CESC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg26338869 chr17:61819248 STRADA -0.62 -7.85 -0.43 1.04e-13 Prudent dietary pattern; CESC cis rs12950390 0.853 rs55745341 chr17:45855778 G/C cg00777063 chr17:45855553 NA -0.38 -5.64 -0.33 4.46e-8 IgG glycosylation; CESC cis rs72781680 0.821 rs12616257 chr2:24135034 A/G cg08917208 chr2:24149416 ATAD2B 0.56 5.6 0.33 5.47e-8 Lymphocyte counts; CESC cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.91e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg04944784 chr2:26401820 FAM59B -0.9 -9.7 -0.51 3.1400000000000002e-19 Gut microbiome composition (summer); CESC cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg26373071 chr5:1325741 CLPTM1L -0.45 -7.05 -0.4 1.58e-11 Lung cancer; CESC cis rs12477438 0.501 rs11123770 chr2:99825102 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.71 10.42 0.54 1.52e-21 Chronic sinus infection; CESC cis rs2066819 1.000 rs75598973 chr12:56746558 C/T cg26714650 chr12:56694279 CS -1.39 -9.06 -0.49 2.88e-17 Psoriasis vulgaris; CESC cis rs11048434 0.761 rs2377675 chr12:9124765 C/T cg23795048 chr12:9217529 LOC144571 0.36 5.46 0.32 1.07e-7 Sjögren's syndrome; CESC cis rs10789491 0.588 rs2099766 chr1:47193987 T/C cg15501359 chr1:47185051 KIAA0494 0.68 6.75 0.38 9.35e-11 Response to hepatitis C treatment; CESC cis rs12477438 0.715 rs6724476 chr2:99627316 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs963731 0.649 rs79361942 chr2:39336315 G/A cg04010122 chr2:39346883 SOS1 0.76 5.65 0.33 4.06e-8 Corticobasal degeneration; CESC cis rs8078723 0.866 rs11078934 chr17:38189793 C/T cg17467752 chr17:38218738 THRA 0.69 11.13 0.56 7.55e-24 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs6598955 0.543 rs6698557 chr1:26561220 G/C cg04990556 chr1:26633338 UBXN11 0.83 9.48 0.5 1.56e-18 Obesity-related traits; CESC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg04166393 chr7:2884313 GNA12 0.59 8.08 0.44 2.29e-14 Height; CESC cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg05340658 chr4:99064831 C4orf37 0.83 12.83 0.62 1.27e-29 Colonoscopy-negative controls vs population controls; CESC cis rs57506017 0.585 rs3807865 chr7:12250402 A/G cg23422036 chr7:12250390 TMEM106B -0.38 -5.11 -0.3 6.2e-7 Neuroticism; CESC cis rs4727027 0.933 rs12532104 chr7:148864233 A/C cg23158103 chr7:148848205 ZNF398 -0.42 -6.88 -0.39 4.26e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2777491 0.574 rs1757468 chr15:41743574 T/A cg20272979 chr15:41787780 ITPKA 0.42 5.18 0.3 4.44e-7 Ulcerative colitis; CESC cis rs1546924 0.570 rs197419 chr1:112315450 G/T cg23955903 chr1:112298873 DDX20;C1orf183 -0.44 -5.74 -0.33 2.65e-8 Body mass index; CESC cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg08847533 chr14:75593920 NEK9 -0.97 -17.65 -0.74 1.22e-46 Height; CESC cis rs4319547 0.656 rs7135419 chr12:122911861 T/A cg05707623 chr12:122985044 ZCCHC8 -0.54 -6.17 -0.35 2.52e-9 Body mass index; CESC cis rs1005224 0.927 rs8007792 chr14:76175666 C/A cg25116370 chr14:76127843 TTLL5;C14orf1 -0.43 -5.83 -0.34 1.57e-8 Large artery stroke; CESC cis rs41271951 0.512 rs34761930 chr1:151089523 T/C cg11822372 chr1:151115635 SEMA6C -0.63 -5.03 -0.3 9.12e-7 Blood protein levels; CESC cis rs116095464 0.558 rs112343653 chr5:257174 G/A cg10591111 chr5:226296 SDHA -0.51 -6.15 -0.35 2.84e-9 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09912005 chr4:123300640 ADAD1 -0.58 -6.23 -0.36 1.83e-9 Gut microbiome composition (summer); CESC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg04369109 chr6:150039330 LATS1 -0.44 -6.24 -0.36 1.7e-9 Lung cancer; CESC cis rs72781680 0.582 rs72783611 chr2:24291445 C/T cg08917208 chr2:24149416 ATAD2B 0.55 5.22 0.31 3.56e-7 Lymphocyte counts; CESC cis rs854765 0.693 rs9907246 chr17:17770965 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.45 -5.83 -0.34 1.58e-8 Total body bone mineral density; CESC cis rs16857609 0.628 rs2068972 chr2:218346451 A/G cg03013118 chr2:218375971 DIRC3 0.28 5.28 0.31 2.7e-7 Breast cancer;Breast cancer (estrogen-receptor negative); CESC cis rs4727027 0.866 rs1405124 chr7:148779618 C/T cg23583168 chr7:148888333 NA -0.79 -11.84 -0.59 3.12e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg10691866 chr7:65817282 TPST1 -0.32 -5.42 -0.32 1.35e-7 Aortic root size; CESC cis rs3749237 0.595 rs35701831 chr3:49515000 A/C cg02487422 chr3:49467188 NICN1 0.56 8.19 0.45 1.12e-14 Resting heart rate; CESC cis rs798554 0.591 rs757791 chr7:2867296 A/G cg19717773 chr7:2847554 GNA12 -0.52 -7.99 -0.44 4.22e-14 Height; CESC cis rs8062405 0.755 rs62034325 chr16:28538640 A/G cg07382826 chr16:28625726 SULT1A1 0.4 6.64 0.38 1.73e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -6.54 -0.37 3.16e-10 Hemoglobin concentration; CESC cis rs7666738 0.546 rs10440329 chr4:98903735 C/T cg17366294 chr4:99064904 C4orf37 0.51 6.53 0.37 3.27e-10 Colonoscopy-negative controls vs population controls; CESC cis rs12220238 1.000 rs11000887 chr10:75897542 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.65 6.33 0.36 1.03e-9 Soluble interleukin-2 receptor subunit alpha; CESC trans rs875971 1.000 rs4717292 chr7:65895598 G/A cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs6842047 1.000 rs72647308 chr4:187135129 G/A cg09526685 chr4:187126073 CYP4V2 -0.7 -5.91 -0.34 1.03e-8 Blood protein levels; CESC cis rs1801251 0.574 rs2250660 chr2:233752551 G/C cg25237894 chr2:233734115 C2orf82 -0.33 -5.44 -0.32 1.19e-7 Coronary artery disease; CESC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg13206674 chr6:150067644 NUP43 0.42 5.82 0.34 1.66e-8 Lung cancer; CESC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg23708337 chr7:1209742 NA 0.52 5.14 0.3 5.37e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg11235426 chr6:292522 DUSP22 -0.73 -9.71 -0.51 2.89e-19 Menopause (age at onset); CESC cis rs11792861 0.781 rs72607158 chr9:111763010 T/C cg13535736 chr9:111863775 C9orf5 -0.46 -5.98 -0.35 7e-9 Menarche (age at onset); CESC cis rs2652822 0.525 rs11632192 chr15:63515946 A/G cg02713581 chr15:63449717 RPS27L 0.49 6.34 0.36 1e-9 Metabolic traits; CESC cis rs66887589 0.967 rs3775842 chr4:120427732 G/A cg09307838 chr4:120376055 NA 0.5 6.65 0.38 1.67e-10 Diastolic blood pressure; CESC cis rs4843747 0.619 rs66508972 chr16:88086385 C/G cg09044154 chr16:88155775 NA -0.47 -5.22 -0.31 3.61e-7 Menopause (age at onset); CESC cis rs4253772 0.591 rs11704586 chr22:46685274 T/C cg18190219 chr22:46762943 CELSR1 -0.59 -5.46 -0.32 1.09e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg05564831 chr3:52568323 NT5DC2 0.46 7.33 0.41 2.88e-12 Bipolar disorder; CESC cis rs2228479 0.702 rs3819574 chr16:89826630 G/A cg00800038 chr16:89945340 TCF25 -0.92 -7.62 -0.42 4.38e-13 Skin colour saturation; CESC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg14393609 chr7:65229607 NA -0.52 -7.14 -0.4 8.77e-12 Aortic root size; CESC cis rs113835537 0.559 rs74933537 chr11:66274958 A/C cg24851651 chr11:66362959 CCS 0.46 5.81 0.34 1.81e-8 Airway imaging phenotypes; CESC cis rs3015469 0.751 rs12891224 chr14:51208143 T/G cg26011998 chr14:51135199 SAV1 0.53 5.94 0.34 9.01e-9 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs8070740 0.898 rs4493114 chr17:5324207 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.28 0.36 1.35e-9 Menopause (age at onset); CESC cis rs694739 1.000 rs499425 chr11:64105929 A/G cg23796481 chr11:64053134 BAD;GPR137 -0.67 -8.62 -0.47 6.29e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs2932538 0.961 rs6537746 chr1:113163529 C/T cg22162597 chr1:113214053 CAPZA1 -0.58 -7.44 -0.42 1.42e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08007338 chr1:180123948 QSOX1 -0.45 -6.13 -0.35 3.11e-9 Fibrinogen levels; CESC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg17178900 chr1:205818956 PM20D1 0.79 12.22 0.6 1.59e-27 Menarche (age at onset); CESC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg05283184 chr6:79620031 NA -0.44 -6.88 -0.39 4.39e-11 Intelligence (multi-trait analysis); CESC trans rs7615952 0.673 rs9841194 chr3:125635739 C/T cg07211511 chr3:129823064 LOC729375 -0.89 -8.15 -0.45 1.47e-14 Blood pressure (smoking interaction); CESC trans rs2975734 0.736 rs4841300 chr8:10112595 T/C cg15556689 chr8:8085844 FLJ10661 -0.59 -6.73 -0.38 1.06e-10 Morning vs. evening chronotype;Chronotype; CESC cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.623 rs1054400 chr17:29109954 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.37 0.36 8.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg05564831 chr3:52568323 NT5DC2 0.46 7.12 0.4 1e-11 Electroencephalogram traits; CESC cis rs7264396 0.563 rs2425094 chr20:34306974 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.65 -0.55 2.79e-22 Total cholesterol levels; CESC cis rs7246657 0.943 rs7252346 chr19:37914682 G/A cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.69e-9 Coronary artery calcification; CESC cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg02297831 chr4:17616191 MED28 0.6 7.63 0.42 4.17e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg13628971 chr7:2884303 GNA12 0.6 7.87 0.44 9.16e-14 Height; CESC cis rs9596863 0.898 rs9316658 chr13:54333620 C/T ch.13.53330881F chr13:54432880 NA -0.59 -5.16 -0.3 4.78e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg05340658 chr4:99064831 C4orf37 0.77 11.6 0.58 2.01e-25 Colonoscopy-negative controls vs population controls; CESC cis rs9325144 0.505 rs826893 chr12:39100536 A/G cg26384229 chr12:38710491 ALG10B -0.59 -9.44 -0.5 2.04e-18 Morning vs. evening chronotype; CESC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg18252515 chr7:66147081 NA 0.44 5.75 0.33 2.44e-8 Aortic root size; CESC cis rs2412819 0.599 rs2470120 chr15:43929070 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.52 6.67 0.38 1.46e-10 Lung cancer; CESC cis rs9815354 0.556 rs56201224 chr3:42004427 A/C cg03022575 chr3:42003672 ULK4 0.64 5.83 0.34 1.62e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg27347728 chr4:17578864 LAP3 0.42 5.08 0.3 7.24e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs73206853 0.764 rs56128816 chr12:110775609 T/C cg12870014 chr12:110450643 ANKRD13A 0.66 5.59 0.32 5.61e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs7740797 0.967 rs3757291 chr6:155124583 G/T cg11972327 chr1:8419796 RERE -0.44 -6.05 -0.35 5.05e-9 Colorectal or endometrial cancer; CESC cis rs11696501 0.694 rs7266372 chr20:44266635 T/C cg11783356 chr20:44313418 WFDC10B -0.34 -5.3 -0.31 2.44e-7 Brain structure; CESC cis rs3820928 1.000 rs978909 chr2:227771389 A/C cg05526886 chr2:227700861 RHBDD1 -0.44 -5.56 -0.32 6.65e-8 Pulmonary function; CESC cis rs79349575 0.715 rs9894220 chr17:46989154 C/T cg16584676 chr17:46985605 UBE2Z 0.71 9.18 0.49 1.25e-17 Type 2 diabetes; CESC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg17971929 chr21:40555470 PSMG1 0.86 12.53 0.61 1.31e-28 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16941144 chr14:45603841 FKBP3;FANCM -0.54 -6.1 -0.35 3.69e-9 Gut microbiome composition (summer); CESC cis rs2952156 0.883 rs8077172 chr17:37834977 G/T cg07936489 chr17:37558343 FBXL20 -0.6 -7.98 -0.44 4.35e-14 Asthma; CESC cis rs7216064 1.000 rs56404791 chr17:65893019 T/G cg12091567 chr17:66097778 LOC651250 -0.71 -8.08 -0.44 2.37e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11718455 0.960 rs11917885 chr3:44008013 A/G cg08738300 chr3:44038990 NA -0.45 -6.06 -0.35 4.56e-9 Coronary artery disease; CESC cis rs2273669 0.667 rs12206606 chr6:109353519 C/A cg05315195 chr6:109294784 ARMC2 -0.67 -6.33 -0.36 1.02e-9 Prostate cancer; CESC trans rs61931739 0.500 rs11053249 chr12:34518834 A/T cg13010199 chr12:38710504 ALG10B 0.5 6.42 0.37 6.3e-10 Morning vs. evening chronotype; CESC cis rs10129255 1.000 rs8012033 chr14:107134871 T/A cg23076370 chr14:107095027 NA -0.41 -5.16 -0.3 4.85e-7 Kawasaki disease; CESC cis rs7084402 0.870 rs1896245 chr10:60276083 T/G cg07615347 chr10:60278583 BICC1 -0.59 -9.42 -0.5 2.33e-18 Refractive error; CESC cis rs9354308 0.933 rs12203567 chr6:66589062 T/C cg07460842 chr6:66804631 NA 0.66 7.47 0.42 1.16e-12 Metabolite levels; CESC cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg25554036 chr4:6271136 WFS1 0.53 8.74 0.47 2.69e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs35955747 0.934 rs4820045 chr22:31785969 G/A cg25791279 chr22:32026902 PISD -0.44 -5.3 -0.31 2.42e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs6543140 0.929 rs11465700 chr2:103057668 G/A cg04239558 chr2:103089729 SLC9A4 0.48 6.04 0.35 5.17e-9 Blood protein levels; CESC trans rs412658 0.668 rs7253490 chr19:22293706 A/C cg05197062 chr11:11642011 GALNTL4 0.42 6.05 0.35 4.87e-9 Telomere length; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16988008 chr11:108463728 EXPH5 0.64 7.82 0.43 1.27e-13 Gut microbiome composition (summer); CESC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg21724239 chr8:58056113 NA 0.77 10.64 0.55 2.97e-22 Developmental language disorder (linguistic errors); CESC cis rs11608355 0.618 rs2075435 chr12:109796832 C/T cg19025524 chr12:109796872 NA -0.58 -8.38 -0.46 3.14e-15 Neuroticism; CESC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg20999797 chr1:1681921 NA 0.27 5.21 0.31 3.71e-7 Body mass index; CESC cis rs7107174 1.000 rs10899453 chr11:77997482 A/C cg02023728 chr11:77925099 USP35 0.51 7.03 0.4 1.74e-11 Testicular germ cell tumor; CESC cis rs2408955 0.522 rs973398 chr12:48491048 A/G cg24011408 chr12:48396354 COL2A1 -0.49 -7.34 -0.41 2.63e-12 Glycated hemoglobin levels; CESC cis rs644148 0.738 rs2686767 chr19:44995037 G/C cg15540054 chr19:45004280 ZNF180 -0.43 -5.35 -0.31 1.94e-7 Personality dimensions; CESC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.36 -0.31 1.82e-7 Total body bone mineral density; CESC cis rs360798 0.553 rs7562734 chr2:63047973 G/C cg17519650 chr2:63277830 OTX1 -0.59 -7.62 -0.42 4.45e-13 Coronary artery disease; CESC trans rs10506458 0.688 rs73127095 chr12:63418283 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.08 -13.72 -0.64 9.72e-33 Hemostatic factors and hematological phenotypes; CESC cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg08917208 chr2:24149416 ATAD2B 0.61 5.78 0.33 2.1e-8 Lymphocyte counts; CESC cis rs1801251 0.711 rs778339 chr2:233739678 T/C cg08000102 chr2:233561755 GIGYF2 -0.6 -8.18 -0.45 1.16e-14 Coronary artery disease; CESC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg06634786 chr22:41940651 POLR3H -0.69 -7.1 -0.4 1.12e-11 Vitiligo; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05556477 chr5:131705319 SLC22A5 -0.42 -6.09 -0.35 3.94e-9 Gambling; CESC cis rs9811920 0.893 rs720688 chr3:99880569 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.43 6.99 0.39 2.28e-11 Axial length; CESC cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.64 7.74 0.43 2.05e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.07 12.6 0.61 7.81e-29 Gut microbiome composition (summer); CESC trans rs7837860 0.541 rs35658486 chr8:89279419 A/G cg04391754 chr17:18022714 MYO15A 0.52 6.12 0.35 3.41e-9 Autism spectrum disorder or schizophrenia; CESC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg07677032 chr17:61819896 STRADA 0.45 5.93 0.34 9.39e-9 Prudent dietary pattern; CESC cis rs12579753 0.692 rs9943807 chr12:82279404 T/A cg23701643 chr12:82153290 PPFIA2 -0.36 -5.31 -0.31 2.36e-7 Resting heart rate; CESC cis rs2204008 0.549 rs12312109 chr12:38228251 G/T cg26384229 chr12:38710491 ALG10B -0.47 -6.22 -0.36 1.89e-9 Bladder cancer; CESC cis rs2625529 0.526 rs62022789 chr15:72564492 C/T cg16672083 chr15:72433130 SENP8 0.42 6.36 0.36 8.62e-10 Red blood cell count; CESC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg26314531 chr2:26401878 FAM59B -0.6 -6.78 -0.38 7.95e-11 Gut microbiome composition (summer); CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.44 5.41 0.32 1.39e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9291683 0.530 rs6449196 chr4:9973660 C/T cg02734326 chr4:10020555 SLC2A9 -0.45 -6.77 -0.38 8.45e-11 Bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07254608 chr8:41997973 NA 0.51 6.71 0.38 1.19e-10 Gut microbiota (bacterial taxa); CESC cis rs8067354 0.574 rs1296279 chr17:57965731 G/A cg02344993 chr17:57696989 CLTC 0.54 5.6 0.33 5.31e-8 Hemoglobin concentration; CESC cis rs11997175 0.550 rs10105616 chr8:33786830 G/A ch.8.33884649F chr8:33765107 NA 0.63 8.07 0.44 2.53e-14 Body mass index; CESC cis rs193541 0.632 rs152038 chr5:122195846 G/A cg19412675 chr5:122181750 SNX24 0.46 5.4 0.31 1.5e-7 Glucose homeostasis traits; CESC cis rs6693567 0.545 rs4446975 chr1:150456169 C/T cg09579323 chr1:150459698 TARS2 0.42 5.53 0.32 7.5e-8 Migraine; CESC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg04414720 chr1:150670196 GOLPH3L 0.56 7.43 0.42 1.52e-12 Melanoma; CESC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg24503407 chr1:205819492 PM20D1 0.39 5.3 0.31 2.42e-7 Parkinson's disease; CESC cis rs703842 1.000 rs10431505 chr12:58178589 A/G cg18357645 chr12:58087776 OS9 -0.39 -5.52 -0.32 8.26e-8 Multiple sclerosis; CESC cis rs35995292 0.534 rs10274968 chr7:38939254 C/T cg19327137 chr7:38886074 VPS41 0.67 11.55 0.58 2.79e-25 Subjective well-being (multi-trait analysis); CESC cis rs71277158 0.688 rs879161 chr3:169812115 A/G cg04067573 chr3:169899625 PHC3 0.68 6.96 0.39 2.62e-11 Prostate cancer; CESC cis rs1401999 1.000 rs2176824 chr3:183654029 C/G cg01324343 chr3:183735012 ABCC5 0.66 14.04 0.65 7.57e-34 Anterior chamber depth; CESC cis rs8017423 0.935 rs17260827 chr14:90732703 G/A cg14092571 chr14:90743983 NA 0.57 8.49 0.46 1.49e-15 Mortality in heart failure; CESC cis rs7208859 0.623 rs60890550 chr17:29030861 A/G cg14008862 chr17:28927542 LRRC37B2 0.67 5.22 0.31 3.58e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs62458065 0.513 rs787220 chr7:32581139 C/G cg20159608 chr7:32802032 NA -0.55 -6.15 -0.35 2.89e-9 Metabolite levels (HVA/MHPG ratio); CESC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg02187348 chr16:89574699 SPG7 0.66 9.26 0.49 7.27e-18 Multiple myeloma (IgH translocation); CESC cis rs8018808 0.846 rs11624990 chr14:77943616 C/T cg20045696 chr14:77926864 AHSA1 0.4 5.41 0.32 1.4e-7 Myeloid white cell count; CESC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg04944784 chr2:26401820 FAM59B 0.95 9.94 0.52 5.28e-20 Gut microbiome composition (summer); CESC cis rs4689388 0.926 rs4688987 chr4:6287329 C/T cg14416269 chr4:6271139 WFS1 0.47 7.85 0.43 1.05e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg02880119 chr16:3481970 NA 0.41 5.13 0.3 5.61e-7 Body mass index (adult); CESC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg11764359 chr7:65958608 NA -0.73 -9.8 -0.52 1.49e-19 Aortic root size; CESC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg21951975 chr1:209979733 IRF6 0.61 9.34 0.5 4.14e-18 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01091156 chr16:87991122 BANP -0.66 -7.79 -0.43 1.5700000000000001e-13 Gut microbiome composition (summer); CESC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg02353165 chr6:42928485 GNMT 0.85 13.6 0.64 2.68e-32 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.98 0.34 7.13e-9 Menopause (age at onset); CESC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg13206674 chr6:150067644 NUP43 0.43 5.98 0.34 7.33e-9 Lung cancer; CESC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg19774624 chr17:42201019 HDAC5 -0.89 -14.85 -0.67 1.01e-36 Total body bone mineral density; CESC cis rs7647973 0.626 rs4855845 chr3:49687043 T/C cg06212747 chr3:49208901 KLHDC8B 0.65 7.85 0.43 1.01e-13 Menarche (age at onset); CESC trans rs1945213 0.659 rs11227133 chr11:55836620 T/C cg03929089 chr4:120376271 NA 0.76 7.26 0.41 4.31e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs8017423 0.605 rs3742673 chr14:90735707 C/T cg14092571 chr14:90743983 NA -0.53 -8.17 -0.45 1.31e-14 Mortality in heart failure; CESC cis rs6963495 0.745 rs75805443 chr7:105162828 A/G cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs72781680 0.898 rs17462433 chr2:24012758 T/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg04025307 chr7:1156635 C7orf50 0.51 8.46 0.46 1.8e-15 Longevity;Endometriosis; CESC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg05564831 chr3:52568323 NT5DC2 0.4 5.62 0.33 4.82e-8 Bipolar disorder; CESC cis rs6963495 0.818 rs73192124 chr7:105171528 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.45 -0.32 1.13e-7 Bipolar disorder (body mass index interaction); CESC cis rs7429990 0.932 rs9862913 chr3:48016172 T/C cg11946769 chr3:48343235 NME6 0.43 5.2 0.3 4e-7 Educational attainment (years of education); CESC trans rs61931739 0.500 rs7979769 chr12:34509522 C/T cg13010199 chr12:38710504 ALG10B 0.5 6.42 0.37 6.3e-10 Morning vs. evening chronotype; CESC cis rs11792861 0.816 rs2304779 chr9:111670513 C/T cg05043794 chr9:111880884 C9orf5 0.33 5.47 0.32 1.03e-7 Menarche (age at onset); CESC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg04944784 chr2:26401820 FAM59B -0.68 -7.66 -0.43 3.57e-13 Gut microbiome composition (summer); CESC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg24549020 chr5:56110836 MAP3K1 0.6 6.65 0.38 1.67e-10 Initial pursuit acceleration; CESC cis rs2236918 1.000 rs2236918 chr1:242017826 C/G cg17736920 chr1:242011382 EXO1 -0.73 -10.02 -0.52 3.1e-20 Menopause (age at onset); CESC cis rs1707322 1.000 rs7538978 chr1:46505054 C/T cg03146154 chr1:46216737 IPP -0.7 -9.56 -0.51 8.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9303401 0.659 rs36109237 chr17:56653834 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.93 0.62 5.59e-30 Cognitive test performance; CESC cis rs10206020 0.921 rs10177509 chr2:1568536 T/C cg26248373 chr2:1572462 NA -0.57 -6.78 -0.38 7.9e-11 IgG glycosylation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15483030 chr1:5935144 NPHP4 0.48 6.1 0.35 3.82e-9 Fibrinogen levels; CESC cis rs7091068 0.616 rs6583905 chr10:95504022 T/G cg20715218 chr10:95462985 C10orf4 0.58 5.34 0.31 1.97e-7 Urinary tract infection frequency; CESC cis rs34779708 0.649 rs34421369 chr10:35550275 G/C cg03585969 chr10:35415529 CREM 0.54 6.19 0.36 2.3e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10517474 chr16:31470676 ARMC5 0.58 6.88 0.39 4.28e-11 Gut microbiome composition (summer); CESC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg14773178 chr5:1868261 NA 0.32 5.71 0.33 3.06e-8 Cardiovascular disease risk factors; CESC cis rs1577917 0.727 rs9351065 chr6:86360428 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.54 -7.18 -0.4 7.14e-12 Response to antipsychotic treatment; CESC cis rs473651 0.967 rs483042 chr2:239335320 A/G cg18131467 chr2:239335373 ASB1 1.01 20.34 0.78 4.61e-56 Multiple system atrophy; CESC cis rs734999 0.588 rs2843402 chr1:2528682 T/C cg20673091 chr1:2541236 MMEL1 -0.44 -7.15 -0.4 8.55e-12 Ulcerative colitis; CESC cis rs10743315 0.778 rs7397459 chr12:19377578 C/G cg02471346 chr12:19282374 PLEKHA5 0.52 5.82 0.34 1.7e-8 Gut microbiota (bacterial taxa); CESC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg14829155 chr15:31115871 NA 0.74 10.23 0.53 6.51e-21 Huntington's disease progression; CESC cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2859741 0.528 rs59729868 chr1:37493710 G/A cg09363841 chr1:37513479 NA -0.51 -7.61 -0.42 4.96e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs73206853 0.764 rs68087637 chr12:110619797 T/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.77 0.33 2.21e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs763014 0.898 rs1045277 chr16:633125 T/C cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC cis rs17253792 0.915 rs78089630 chr14:56178584 G/C cg01858014 chr14:56050164 KTN1 -0.91 -7.03 -0.4 1.8e-11 Putamen volume; CESC cis rs17376456 0.877 rs28418572 chr5:93144161 A/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.23 0.31 3.42e-7 Diabetic retinopathy; CESC cis rs826838 0.935 rs1719855 chr12:39127242 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.53e-9 Heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09797031 chr1:231473707 C1orf124;EXOC8 0.58 6.18 0.35 2.43e-9 Gut microbiome composition (summer); CESC cis rs6088580 0.634 rs6120644 chr20:33023810 G/A cg08999081 chr20:33150536 PIGU 0.65 11.36 0.57 1.22e-24 Glomerular filtration rate (creatinine); CESC trans rs61931739 0.517 rs7139189 chr12:34319757 T/C cg26384229 chr12:38710491 ALG10B 0.47 6.29 0.36 1.3e-9 Morning vs. evening chronotype; CESC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg22823121 chr1:150693482 HORMAD1 0.36 5.1 0.3 6.36e-7 Melanoma; CESC cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg23711669 chr6:146136114 FBXO30 1.02 15.57 0.69 2.89e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs1371867 0.846 rs1788199 chr8:101292854 A/G cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.24e-11 Atrioventricular conduction; CESC cis rs17125944 0.542 rs75723366 chr14:53256882 T/C cg00686598 chr14:53173677 PSMC6 1.33 11.53 0.58 3.4e-25 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06917231 chr6:28234854 ZNF187 0.57 6.86 0.39 4.81e-11 Gut microbiome composition (summer); CESC cis rs3820068 0.581 rs72645890 chr1:15930602 A/G cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg27170947 chr2:26402098 FAM59B 0.87 9.89 0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs6500395 0.963 rs6500404 chr16:48690083 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg06873352 chr17:61820015 STRADA 0.7 12.02 0.59 7.36e-27 Prudent dietary pattern; CESC cis rs17376456 0.825 rs6877030 chr5:93201841 C/A cg25358565 chr5:93447407 FAM172A 1.11 10.79 0.55 9.8e-23 Diabetic retinopathy; CESC cis rs873946 0.564 rs2803991 chr10:134557068 A/G cg26818010 chr10:134567672 INPP5A -0.7 -8.73 -0.47 2.82e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg24110177 chr3:50126178 RBM5 0.54 7.52 0.42 8.35e-13 Intelligence (multi-trait analysis); CESC cis rs4975616 0.869 rs452384 chr5:1330840 T/C cg26373071 chr5:1325741 CLPTM1L 0.43 6.92 0.39 3.37e-11 Lung cancer; CESC cis rs7949030 0.653 rs2516634 chr11:62367186 G/A cg23462726 chr11:62437636 C11orf83;C11orf48 0.41 5.42 0.32 1.35e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs983392 0.679 rs7930318 chr11:60033371 C/T cg13921652 chr1:144931966 PDE4DIP 0.48 6.12 0.35 3.29e-9 Alzheimer's disease (late onset); CESC cis rs7589342 0.628 rs10496403 chr2:106419622 T/G cg16077055 chr2:106428750 NCK2 0.56 7.13 0.4 9.6e-12 Addiction; CESC cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg07636037 chr3:49044803 WDR6 1.08 19.55 0.77 2.71e-53 Parkinson's disease; CESC cis rs6032067 1.000 rs13041304 chr20:43811697 G/A cg11264863 chr20:43835661 SEMG1 0.48 5.31 0.31 2.32e-7 Blood protein levels; CESC cis rs965469 1.000 rs6051763 chr20:3321616 T/G cg25506879 chr20:3388711 C20orf194 -0.51 -5.59 -0.32 5.65e-8 IFN-related cytopenia; CESC trans rs2018683 0.707 rs917218 chr7:28975122 A/C cg19402173 chr7:128379420 CALU -0.46 -6.05 -0.35 4.94e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09567311 chr17:53316197 NA 0.47 6.87 0.39 4.55e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4689592 0.554 rs3822270 chr4:7069804 C/A cg06697600 chr4:7070879 GRPEL1 -0.49 -7.23 -0.41 5.09e-12 Monocyte percentage of white cells; CESC cis rs79387448 0.701 rs10515921 chr2:102981018 T/G cg09003973 chr2:102972529 NA 1.19 9.2 0.49 1.13e-17 Gut microbiota (bacterial taxa); CESC trans rs11039798 0.582 rs1483119 chr11:48382334 A/G cg15704280 chr7:45808275 SEPT13 -0.69 -6.75 -0.38 9.03e-11 Axial length; CESC cis rs9916302 0.752 rs6503513 chr17:37561613 A/G cg20243544 chr17:37824526 PNMT -0.52 -5.87 -0.34 1.29e-8 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg03467027 chr4:99064603 C4orf37 0.44 5.41 0.32 1.4e-7 Colonoscopy-negative controls vs population controls; CESC cis rs57221529 0.608 rs11749927 chr5:668842 C/T cg16447950 chr5:562315 NA -0.56 -6.39 -0.37 7.27e-10 Lung disease severity in cystic fibrosis; CESC cis rs728616 0.681 rs17677908 chr10:82049603 A/G cg05935833 chr10:81318306 SFTPA2 -0.44 -5.53 -0.32 7.71e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg00149659 chr3:10157352 C3orf10 -0.56 -6.84 -0.39 5.34e-11 Alzheimer's disease; CESC cis rs78366141 0.649 rs10428273 chr4:89672738 G/A cg01026744 chr4:89619053 NAP1L5;HERC3 0.79 5.64 0.33 4.32e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.86 0.34 1.34e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9488822 0.676 rs12154016 chr6:116355188 C/T cg26893134 chr6:116381904 FRK 0.25 6.08 0.35 4.16e-9 Cholesterol, total;LDL cholesterol; CESC cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg00701064 chr4:6280414 WFS1 0.68 11.32 0.57 1.77e-24 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs644799 0.965 rs545342 chr11:95545369 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9902453 0.817 rs2628170 chr17:28056612 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.74 -9.63 -0.51 5.31e-19 Coffee consumption (cups per day); CESC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg06481639 chr22:41940642 POLR3H 0.61 5.94 0.34 8.81e-9 Vitiligo; CESC cis rs155076 1.000 rs9509638 chr13:21860193 G/A cg11317459 chr13:21872234 NA -1.08 -11.42 -0.57 7.79e-25 White matter hyperintensity burden; CESC cis rs72945132 0.882 rs17853270 chr11:70200529 C/T cg14191688 chr11:70257035 CTTN 0.44 5.31 0.31 2.37e-7 Coronary artery disease; CESC cis rs9300255 0.602 rs10744147 chr12:123643729 A/G cg00376283 chr12:123451042 ABCB9 0.57 6.44 0.37 5.55e-10 Neutrophil percentage of white cells; CESC cis rs2281845 0.507 rs942703 chr1:201092979 A/G cg06714761 chr1:201096289 NA -0.43 -6.64 -0.38 1.77e-10 Permanent tooth development; CESC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg21963583 chr11:68658836 MRPL21 0.4 5.64 0.33 4.32e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1707322 0.752 rs11211145 chr1:46108491 A/C cg06784218 chr1:46089804 CCDC17 0.4 6.62 0.38 2.02e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs863345 0.967 rs12081915 chr1:158533224 A/G cg12129480 chr1:158549410 OR10X1 -0.33 -6.62 -0.38 1.93e-10 Pneumococcal bacteremia; CESC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg24675658 chr1:53192096 ZYG11B -0.56 -7.08 -0.4 1.27e-11 Monocyte count; CESC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 4.97e-9 Prudent dietary pattern; CESC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs13336428 0.730 rs3946124 chr16:1525779 A/G cg08008072 chr16:1524255 CLCN7 0.73 12.58 0.61 9.14e-29 Bone mineral density; CESC cis rs295140 0.605 rs1436164 chr2:201158411 C/T cg23649088 chr2:200775458 C2orf69 -0.4 -5.21 -0.31 3.71e-7 QT interval; CESC cis rs2439831 0.867 rs6493085 chr15:43654182 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.46 0.54 1.12e-21 Lung cancer in ever smokers; CESC cis rs11677416 1.000 rs6542092 chr2:113528322 C/G cg27083787 chr2:113543245 IL1A 0.41 5.16 0.3 4.75e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs10752881 0.967 rs12404594 chr1:182988027 G/A ch.1.3577855R chr1:183094577 LAMC1 0.8 12.34 0.6 6.01e-28 Colorectal cancer; CESC cis rs17433780 0.504 rs7525985 chr1:89460948 C/T cg09516651 chr1:89888402 LOC400759 0.47 6.47 0.37 4.81e-10 Carotid intima media thickness; CESC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg12463550 chr7:65579703 CRCP 0.49 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.71 0.43 2.57e-13 Prudent dietary pattern; CESC cis rs9322193 0.886 rs9767555 chr6:149968158 T/C cg07701084 chr6:150067640 NUP43 0.4 5.44 0.32 1.19e-7 Lung cancer; CESC cis rs4072980 0.545 rs16824518 chr1:38415315 A/C cg17077180 chr1:38461687 NA -0.39 -5.23 -0.31 3.45e-7 Coronary artery disease; CESC cis rs6938 0.534 rs11854704 chr15:75221015 C/T cg09165964 chr15:75287851 SCAMP5 0.45 6.02 0.35 5.86e-9 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09538139 chr9:127532208 NR6A1 -0.45 -6.23 -0.36 1.84e-9 Gut microbiota (bacterial taxa); CESC cis rs1348850 0.914 rs9789582 chr2:178330173 C/G cg22681709 chr2:178499509 PDE11A -0.43 -6.1 -0.35 3.67e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg06420487 chr17:61919686 SMARCD2 0.46 5.47 0.32 1.05e-7 Height; CESC cis rs4547160 0.788 rs12227007 chr12:63484710 G/T cg26727693 chr12:63544175 AVPR1A -0.36 -5.22 -0.31 3.6e-7 Morning vs. evening chronotype; CESC cis rs2294693 0.679 rs1534995 chr6:40960731 G/A cg14418226 chr6:40996092 UNC5CL 0.45 5.08 0.3 7.03e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs12682352 0.652 rs1567398 chr8:8726804 A/C cg15556689 chr8:8085844 FLJ10661 -0.49 -6.3 -0.36 1.25e-9 Neuroticism; CESC trans rs2207136 0.835 rs568642 chr6:50904360 C/G cg06522515 chr3:184090630 THPO -0.36 -6.26 -0.36 1.56e-9 Myopia; CESC cis rs2274273 0.624 rs7150234 chr14:55802181 A/G cg04306507 chr14:55594613 LGALS3 0.29 5.12 0.3 5.74e-7 Protein biomarker; CESC trans rs7246760 0.867 rs61580479 chr19:9782940 G/A cg02900749 chr2:68251473 NA -0.84 -7.5 -0.42 9.78e-13 Pursuit maintenance gain; CESC cis rs6546550 0.901 rs10205487 chr2:70151471 C/T cg02498382 chr2:70120550 SNRNP27 0.36 6.16 0.35 2.74e-9 Prevalent atrial fibrillation; CESC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg11764359 chr7:65958608 NA 0.67 8.6 0.47 7.12e-16 Aortic root size; CESC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg20862496 chr8:143823734 SLURP1 0.34 5.35 0.31 1.92e-7 Urinary tract infection frequency; CESC cis rs10979 0.557 rs9376767 chr6:143909380 G/A cg25407410 chr6:143891975 LOC285740 -0.49 -6.47 -0.37 4.64e-10 Hypospadias; CESC cis rs853679 1.000 rs6905391 chr6:28262686 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.67 6.93 0.39 3.12e-11 Depression; CESC trans rs35110281 0.807 rs6518301 chr21:45016818 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 6.31 0.36 1.15e-9 Mean corpuscular volume; CESC trans rs1814175 0.645 rs28454367 chr11:50045708 G/A cg03929089 chr4:120376271 NA -0.91 -14.92 -0.68 5.78e-37 Height; CESC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.71 6.1 0.35 3.74e-9 Platelet count; CESC cis rs9291683 0.530 rs73227883 chr4:9979279 T/C cg02734326 chr4:10020555 SLC2A9 0.46 6.84 0.39 5.39e-11 Bone mineral density; CESC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg25319279 chr11:5960081 NA 0.41 6.11 0.35 3.51e-9 DNA methylation (variation); CESC cis rs7827545 1.000 rs62523736 chr8:135560916 A/T cg17885191 chr8:135476712 NA 0.47 6.31 0.36 1.18e-9 Hypertension (SNP x SNP interaction); CESC cis rs8058578 1.000 rs7204278 chr16:30730274 A/G cg00531865 chr16:30841666 NA -0.44 -5.9 -0.34 1.11e-8 Multiple myeloma; CESC cis rs7580658 0.963 rs10803585 chr2:128130108 G/A cg10021288 chr2:128175891 PROC -0.41 -6.47 -0.37 4.66e-10 Protein C levels; CESC cis rs897984 0.542 rs7197717 chr16:31083075 A/C cg00531865 chr16:30841666 NA -0.37 -5.26 -0.31 2.92e-7 Dementia with Lewy bodies; CESC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg04317338 chr11:64019027 PLCB3 0.9 9.39 0.5 2.86e-18 Mean platelet volume; CESC trans rs6923462 0.735 rs10498671 chr6:7797591 T/C cg24010885 chr20:30102097 HM13 0.55 6.03 0.35 5.47e-9 Lung function (forced vital capacity); CESC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg22508957 chr16:3507546 NAT15 -0.59 -10.14 -0.53 1.26e-20 Tuberculosis; CESC cis rs1267303 0.642 rs6670699 chr1:46997270 C/T cg25110126 chr1:46999211 NA 1.06 11.5 0.58 4.25e-25 Monobrow; CESC cis rs4812048 0.901 rs151358 chr20:57610059 C/A cg14073986 chr20:57617431 SLMO2 0.5 5.06 0.3 7.92e-7 Mean platelet volume; CESC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg07414643 chr4:187882934 NA 0.48 6.94 0.39 2.96e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs61931739 0.500 rs10844789 chr12:34202279 C/G cg26384229 chr12:38710491 ALG10B 0.64 9.15 0.49 1.59e-17 Morning vs. evening chronotype; CESC cis rs17125944 0.505 rs17125762 chr14:53289288 A/G cg13660082 chr14:53194042 PSMC6 -0.84 -6.77 -0.38 8.02e-11 Alzheimer's disease (late onset); CESC cis rs11792861 0.962 rs3750452 chr9:111801353 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.46 5.74 0.33 2.64e-8 Menarche (age at onset); CESC cis rs2979489 0.945 rs12548554 chr8:30346544 G/A cg26383811 chr8:30366931 RBPMS -0.81 -9.65 -0.51 4.48e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs4242434 0.699 rs878053 chr8:22483849 T/C cg03733263 chr8:22462867 KIAA1967 0.73 10.33 0.54 3.13e-21 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04569364 chr19:57922590 ZNF17 0.47 6.02 0.35 5.91e-9 Gut microbiota (bacterial taxa); CESC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.2 -0.3 3.97e-7 Gut microbiome composition (summer); CESC cis rs244293 0.931 rs2170942 chr17:53209515 A/C cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.09 -0.3 6.87e-7 Menarche (age at onset); CESC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg17724175 chr1:150552817 MCL1 0.35 5.48 0.32 9.68e-8 Melanoma; CESC cis rs4969178 0.965 rs12450500 chr17:76395750 C/T cg20026190 chr17:76395443 PGS1 0.49 7.81 0.43 1.34e-13 HDL cholesterol levels; CESC cis rs12497850 1.000 rs4858831 chr3:48735558 C/T cg03060546 chr3:49711283 APEH 0.43 5.37 0.31 1.7e-7 Parkinson's disease; CESC cis rs67257959 0.708 rs10406406 chr19:17198073 C/T cg16202187 chr19:17186497 HAUS8;MYO9B 0.42 5.07 0.3 7.52e-7 Selective IgA deficiency; CESC cis rs453301 0.686 rs10217044 chr8:8894752 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -6.01 -0.35 6.06e-9 Joint mobility (Beighton score); CESC cis rs3749237 0.595 rs4855864 chr3:49521974 C/T cg07636037 chr3:49044803 WDR6 0.64 9.26 0.49 7.21e-18 Resting heart rate; CESC cis rs67460515 0.563 rs4494975 chr3:160866768 C/T cg03342759 chr3:160939853 NMD3 -0.53 -6.82 -0.39 6.25e-11 Parkinson's disease; CESC cis rs782590 0.721 rs782641 chr2:55929294 C/T cg18811423 chr2:55921094 PNPT1 0.76 11.62 0.58 1.68e-25 Metabolic syndrome; CESC cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg06697600 chr4:7070879 GRPEL1 -0.5 -7.34 -0.41 2.58e-12 Monocyte percentage of white cells; CESC cis rs4835473 0.863 rs11735239 chr4:144610525 A/T cg25736465 chr4:144833511 NA -0.44 -6.52 -0.37 3.44e-10 Immature fraction of reticulocytes; CESC trans rs9929218 0.954 rs35794312 chr16:68827785 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.03 -0.44 3.1e-14 Colorectal cancer; CESC cis rs3008870 0.920 rs3008860 chr1:67391003 G/C cg02640540 chr1:67518911 SLC35D1 0.49 5.29 0.31 2.6e-7 Lymphocyte percentage of white cells; CESC cis rs8180040 0.966 rs13075233 chr3:47420627 T/C cg27129171 chr3:47204927 SETD2 0.64 9.85 0.52 1.05e-19 Colorectal cancer; CESC cis rs12950390 0.853 rs67441169 chr17:45854462 T/G cg00777063 chr17:45855553 NA -0.39 -5.74 -0.33 2.62e-8 IgG glycosylation; CESC trans rs875971 0.660 rs13224319 chr7:66007363 A/G cg26939375 chr7:64535504 NA 0.63 8.63 0.47 5.93e-16 Aortic root size; CESC cis rs7085104 0.700 rs743572 chr10:104597152 A/G cg04362960 chr10:104952993 NT5C2 0.51 6.55 0.37 2.95e-10 Immature fraction of reticulocytes;Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03609269 chr1:53393023 SCP2 -0.43 -6.11 -0.35 3.61e-9 Gambling; CESC cis rs1799949 0.930 rs34210004 chr17:41370337 A/T cg25072359 chr17:41440525 NA 0.52 7.59 0.42 5.46e-13 Menopause (age at onset); CESC cis rs7402982 0.625 rs4966011 chr15:99204006 G/A cg03437748 chr15:99193247 IGF1R 0.62 8.25 0.45 7.46e-15 Birth weight; CESC cis rs61776719 0.738 rs7555461 chr1:38444749 T/C cg12658694 chr1:38397304 INPP5B -0.76 -11.14 -0.56 6.69e-24 Coronary artery disease; CESC cis rs9354308 0.933 rs55672811 chr6:66571730 G/A cg07460842 chr6:66804631 NA 0.68 7.77 0.43 1.68e-13 Metabolite levels; CESC cis rs735860 0.726 rs209517 chr6:53206989 A/T cg10236188 chr6:53219634 NA 0.35 5.26 0.31 2.92e-7 Glaucoma; CESC cis rs9309473 1.000 rs10496191 chr2:73673798 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.22 -0.36 1.95e-9 Metabolite levels; CESC cis rs2011503 0.941 rs112253053 chr19:19425145 T/A cg11584989 chr19:19387371 SF4 0.67 8.03 0.44 3.2e-14 Bipolar disorder; CESC cis rs2070433 0.539 rs721131 chr21:47957767 T/C cg12379764 chr21:47803548 PCNT 0.62 8.18 0.45 1.17e-14 Lymphocyte counts; CESC cis rs9487051 0.676 rs9372208 chr6:109596168 A/G cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC cis rs9911578 0.935 rs2302189 chr17:56584205 A/C cg10487724 chr17:56770010 TEX14;RAD51C -0.42 -5.3 -0.31 2.42e-7 Intelligence (multi-trait analysis); CESC cis rs1152591 1.000 rs2738413 chr14:64679960 A/G cg23250157 chr14:64679961 SYNE2 0.55 8.13 0.45 1.64e-14 Atrial fibrillation; CESC trans rs66887589 0.616 rs11098498 chr4:120187119 T/C cg25214090 chr10:38739885 LOC399744 0.44 6.14 0.35 3.05e-9 Diastolic blood pressure; CESC cis rs27434 0.607 rs34753 chr5:96150911 C/T cg16492584 chr5:96139282 ERAP1 -0.37 -5.43 -0.32 1.29e-7 Ankylosing spondylitis; CESC cis rs611744 0.517 rs62537573 chr8:109269281 C/T cg21045802 chr8:109455806 TTC35 0.56 6.95 0.39 2.89e-11 Dupuytren's disease; CESC cis rs7208859 0.623 rs55938328 chr17:29117010 T/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs763014 0.931 rs11643039 chr16:634260 G/A cg09263875 chr16:632152 PIGQ 0.67 11.3 0.57 1.94e-24 Height; CESC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg00166722 chr3:10149974 C3orf24 0.48 6.41 0.37 6.72e-10 Alzheimer's disease; CESC cis rs60871478 0.947 rs62432255 chr7:804219 G/A cg27478167 chr7:817139 HEATR2 -0.49 -5.88 -0.34 1.23e-8 Cerebrospinal P-tau181p levels; CESC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg08632164 chr7:65971372 NA 0.31 5.11 0.3 6.27e-7 Aortic root size; CESC cis rs1348850 0.645 rs4893963 chr2:178430747 A/G cg23306229 chr2:178417860 TTC30B -0.73 -8.13 -0.45 1.61e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7589342 0.831 rs34554853 chr2:106448931 G/A cg16077055 chr2:106428750 NCK2 0.49 6.98 0.39 2.34e-11 Addiction; CESC cis rs400736 0.602 rs7553544 chr1:8165719 C/T cg25007680 chr1:8021821 PARK7 -0.57 -6.24 -0.36 1.68e-9 Response to antidepressants and depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13446153 chr8:41435704 AGPAT6 0.53 6.09 0.35 4.05e-9 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15065896 chr3:37285038 GOLGA4 -0.46 -6.61 -0.38 2.04e-10 Gambling; CESC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg11764359 chr7:65958608 NA 0.8 10.0 0.52 3.53e-20 Aortic root size; CESC cis rs13256369 0.851 rs13266562 chr8:8564065 T/C cg18904891 chr8:8559673 CLDN23 0.73 8.12 0.45 1.74e-14 Obesity-related traits; CESC cis rs2204008 0.811 rs12368410 chr12:38305705 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.16 0.53 1.08e-20 Bladder cancer; CESC cis rs1707322 1.000 rs1768807 chr1:46510570 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.65 -0.33 4.08e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6754311 0.731 rs218174 chr2:136658345 C/T cg15123519 chr2:136567270 LCT 0.3 5.08 0.3 7.19e-7 Mosquito bite size; CESC cis rs763121 0.853 rs2235230 chr22:39124467 A/G cg21395723 chr22:39101663 GTPBP1 -0.43 -5.19 -0.3 4.24e-7 Menopause (age at onset); CESC cis rs2635047 1.000 rs2684826 chr18:44679147 A/G cg19077165 chr18:44547161 KATNAL2 -0.45 -6.03 -0.35 5.56e-9 Educational attainment; CESC cis rs6674176 0.628 rs4660759 chr1:44432500 C/G cg13606994 chr1:44402422 ARTN -0.39 -5.79 -0.34 1.96e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs694739 1.000 rs499425 chr11:64105929 A/G cg02228329 chr11:64053129 BAD;GPR137 -0.66 -8.33 -0.46 4.5e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg16680214 chr1:154839983 KCNN3 -0.45 -6.95 -0.39 2.84e-11 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14198950 chr1:153913380 DENND4B -0.55 -6.54 -0.37 3.23e-10 Gut microbiome composition (summer); CESC cis rs523522 0.962 rs55848094 chr12:120966659 G/A cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs9399137 0.507 rs6940258 chr6:135366132 C/T cg24558204 chr6:135376177 HBS1L 0.64 8.65 0.47 5.15e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17524854 chr12:67663046 CAND1 0.47 6.11 0.35 3.6e-9 Systemic lupus erythematosus; CESC cis rs6580649 0.941 rs7296913 chr12:48488920 G/A cg05342945 chr12:48394962 COL2A1 0.5 5.71 0.33 3.04e-8 Lung cancer; CESC trans rs8073060 0.544 rs7211724 chr17:33993414 C/G cg19694781 chr19:47549865 TMEM160 -0.75 -7.46 -0.42 1.21e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs71403859 0.730 rs12447672 chr16:71715131 G/A cg08717414 chr16:71523259 ZNF19 -0.73 -6.29 -0.36 1.31e-9 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10382060 chr16:4853033 ROGDI 0.64 7.22 0.41 5.56e-12 Gut microbiome composition (summer); CESC cis rs72781680 0.566 rs6714016 chr2:23899948 A/G cg20701182 chr2:24300061 SF3B14 0.71 7.18 0.4 7.24e-12 Lymphocyte counts; CESC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg00149659 chr3:10157352 C3orf10 0.77 9.07 0.49 2.81e-17 Alzheimer's disease; CESC cis rs4969178 0.931 rs3826323 chr17:76400268 C/G cg05887092 chr17:76393375 PGS1 0.58 9.26 0.49 7e-18 HDL cholesterol levels; CESC cis rs9435341 0.965 rs9435441 chr1:107603330 C/G cg09367891 chr1:107599246 PRMT6 -0.57 -7.28 -0.41 3.91e-12 Facial morphology (factor 21, depth of nasal alae); CESC cis rs7818688 0.697 rs74633621 chr8:95981037 A/G cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs763121 0.925 rs5757251 chr22:39100128 G/A cg06544989 chr22:39130855 UNC84B 0.45 8.43 0.46 2.18e-15 Menopause (age at onset); CESC cis rs2180341 0.924 rs9285459 chr6:127631113 T/C cg27446573 chr6:127587934 RNF146 1.09 16.33 0.71 5.73e-42 Breast cancer; CESC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.99e-8 Eye color traits; CESC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg25036284 chr2:26402008 FAM59B -0.71 -8.2 -0.45 1.05e-14 Gut microbiome composition (summer); CESC cis rs1538970 1.000 rs2492840 chr1:45849792 C/A cg05343316 chr1:45956843 TESK2 0.78 11.0 0.56 1.93e-23 Platelet count; CESC cis rs10089 1.000 rs4836370 chr5:127499224 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.62 0.55 3.42e-22 Ileal carcinoids; CESC cis rs4704187 0.687 rs10066946 chr5:74508021 T/A cg03227963 chr5:74354835 NA 0.28 5.19 0.3 4.21e-7 Response to amphetamines; CESC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg04025307 chr7:1156635 C7orf50 0.45 7.35 0.41 2.48e-12 Longevity;Endometriosis; CESC cis rs6121246 0.512 rs6060941 chr20:30367383 C/T cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg12667521 chr19:29218732 NA 0.48 6.4 0.37 6.97e-10 Methadone dose in opioid dependence; CESC cis rs2742234 0.541 rs10899782 chr10:43736361 A/T cg07801480 chr10:43725741 RASGEF1A -0.4 -5.13 -0.3 5.71e-7 Hirschsprung disease; CESC cis rs9399135 0.967 rs952674 chr6:135349157 A/G cg22676075 chr6:135203613 NA 0.51 7.36 0.41 2.34e-12 Red blood cell count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09726469 chr1:150552014 MCL1 0.5 6.4 0.37 7.01e-10 Gut microbiota (bacterial taxa); CESC cis rs6967414 0.786 rs6948965 chr7:6758547 G/A cg09896999 chr7:6746977 ZNF12 -0.52 -6.19 -0.36 2.31e-9 Hematocrit;Hemoglobin concentration; CESC cis rs3740713 1.000 rs35593189 chr11:18468378 C/T cg23797887 chr11:18477753 LDHAL6A -0.53 -5.29 -0.31 2.59e-7 Amyotrophic lateral sclerosis (sporadic); CESC trans rs12310956 0.532 rs1525903 chr12:33964163 T/C cg26384229 chr12:38710491 ALG10B 0.52 7.15 0.4 8.38e-12 Morning vs. evening chronotype; CESC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg26839252 chr6:160211577 TCP1;MRPL18 0.49 6.15 0.35 2.83e-9 Age-related macular degeneration (geographic atrophy); CESC cis rs9359856 0.510 rs2768936 chr6:90441851 A/G cg13799429 chr6:90582589 CASP8AP2 -0.7 -7.84 -0.43 1.11e-13 Bipolar disorder; CESC trans rs1429606 1.000 rs12659535 chr5:87305069 A/C cg12139725 chr1:38219781 EPHA10 0.63 6.7 0.38 1.26e-10 Number of children (6+ vs. 0 or 1); CESC cis rs11098499 0.697 rs4373140 chr4:120307698 A/G cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15576692 chr20:18548019 LOC388789 0.59 6.63 0.38 1.84e-10 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01511534 chr16:3284640 ZNF200 -0.44 -6.62 -0.38 2.02e-10 Gambling; CESC cis rs4919087 0.715 rs13439 chr10:99006083 C/T cg25902810 chr10:99078978 FRAT1 -0.46 -5.26 -0.31 3e-7 Monocyte count; CESC cis rs7818688 0.614 rs6989591 chr8:95874580 T/C cg16049864 chr8:95962084 TP53INP1 0.51 5.26 0.31 2.91e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21548869 chr14:105834472 PACS2 -0.53 -6.07 -0.35 4.37e-9 Gut microbiome composition (summer); CESC cis rs6088590 0.735 rs2273684 chr20:33529766 G/T cg06115741 chr20:33292138 TP53INP2 -0.5 -6.29 -0.36 1.34e-9 Coronary artery disease; CESC cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg05347473 chr6:146136440 FBXO30 0.59 7.59 0.42 5.36e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs796364 1.000 rs281771 chr2:200812202 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.8 -8.54 -0.46 1.05e-15 Schizophrenia; CESC trans rs1973993 0.691 rs1980684 chr1:96890636 A/G cg10631902 chr5:14652156 NA 0.61 9.46 0.5 1.72e-18 Weight; CESC trans rs61931739 0.500 rs11053203 chr12:34456593 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.28 0.36 1.38e-9 Morning vs. evening chronotype; CESC cis rs9931543 0.504 rs9922112 chr16:56314687 A/C cg02433656 chr16:56322654 GNAO1 0.41 5.3 0.31 2.46e-7 Subjective well-being; CESC cis rs258892 0.895 rs153320 chr5:72138452 C/T cg21869765 chr5:72125136 TNPO1 -0.46 -5.87 -0.34 1.31e-8 Small cell lung carcinoma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19105362 chr10:71929497 SAR1A 0.46 6.27 0.36 1.5e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11931598 0.514 rs10937779 chr4:7039326 G/A cg19539972 chr4:7069911 GRPEL1 0.38 5.26 0.31 2.96e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC cis rs7551222 0.752 rs4951393 chr1:204489557 A/C cg20240347 chr1:204465584 NA 0.27 5.54 0.32 7.3e-8 Schizophrenia; CESC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg06221963 chr1:154839813 KCNN3 -0.7 -12.21 -0.6 1.62e-27 Prostate cancer; CESC cis rs10751667 0.961 rs6597951 chr11:991530 C/T cg20946044 chr11:1010712 AP2A2 -0.46 -5.85 -0.34 1.43e-8 Alzheimer's disease (late onset); CESC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg24818145 chr4:99064322 C4orf37 0.38 5.03 0.3 8.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7399018 1.000 rs7399018 chr12:51610365 C/T cg25754956 chr12:51612065 POU6F1 -0.68 -7.65 -0.43 3.76e-13 Cisplatin-induced ototoxicity; CESC cis rs765787 0.530 rs3759895 chr15:45543870 G/A cg24006582 chr15:45444508 DUOX1 -0.6 -7.3 -0.41 3.41e-12 Uric acid levels; CESC cis rs9487051 0.752 rs9372209 chr6:109601684 T/C cg01475377 chr6:109611718 NA -0.45 -7.12 -0.4 1e-11 Reticulocyte fraction of red cells; CESC cis rs2276314 0.857 rs62101379 chr18:33584902 G/A cg19628046 chr18:33552617 C18orf21 0.51 5.55 0.32 6.97e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7772486 0.654 rs1011597 chr6:146075672 A/C cg05347473 chr6:146136440 FBXO30 -0.54 -7.07 -0.4 1.34e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9300255 0.602 rs1727315 chr12:123638930 A/G cg19016782 chr12:123741754 C12orf65 0.41 5.76 0.33 2.3e-8 Neutrophil percentage of white cells; CESC cis rs6939532 0.522 rs9366652 chr6:26354219 C/G cg14345882 chr6:26364793 BTN3A2 0.39 6.26 0.36 1.54e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 -0.91 -9.32 -0.5 4.62e-18 Platelet count; CESC cis rs2404602 0.619 rs7342603 chr15:76982625 C/T cg22467129 chr15:76604101 ETFA -0.34 -5.12 -0.3 5.9e-7 Blood metabolite levels; CESC cis rs7107174 0.792 rs10751287 chr11:78072476 T/C cg02023728 chr11:77925099 USP35 0.38 5.29 0.31 2.58e-7 Testicular germ cell tumor; CESC cis rs734999 0.588 rs2843403 chr1:2529097 T/C cg18854424 chr1:2615690 NA -0.28 -5.61 -0.33 5.2100000000000003e-08 Ulcerative colitis; CESC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.56 0.8 3.13e-60 Prudent dietary pattern; CESC cis rs2072499 1.000 rs2241108 chr1:156181007 C/G cg25208724 chr1:156163844 SLC25A44 0.98 18.37 0.75 3.62e-49 Testicular germ cell tumor; CESC cis rs1784581 0.706 rs9346895 chr6:162431168 T/C cg17173639 chr6:162384350 PARK2 0.61 9.62 0.51 5.63e-19 Itch intensity from mosquito bite; CESC cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg25019033 chr10:957182 NA -0.64 -8.23 -0.45 8.48e-15 Eosinophil percentage of granulocytes; CESC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7264396 0.790 rs6058290 chr20:34247702 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.7 0.43 2.63e-13 Total cholesterol levels; CESC cis rs9611565 0.592 rs4481089 chr22:41980892 T/C cg06481639 chr22:41940642 POLR3H -0.56 -6.32 -0.36 1.13e-9 Vitiligo; CESC cis rs4790333 0.531 rs2447107 chr17:2257864 A/G cg02569219 chr17:2266849 SGSM2 0.39 5.15 0.3 5e-7 Proinsulin levels; CESC cis rs4237845 0.537 rs7312623 chr12:58262523 G/T cg02175503 chr12:58329896 NA 0.49 5.85 0.34 1.42e-8 Intelligence (multi-trait analysis); CESC trans rs9914544 0.544 rs4244595 chr17:18677329 C/T cg04702396 chr17:15466718 FAM18B2 0.48 6.07 0.35 4.3e-9 Educational attainment (years of education); CESC cis rs18122 0.660 rs12479293 chr2:67521205 G/A cg09028215 chr2:67624308 ETAA1 -0.41 -5.13 -0.3 5.5e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs754466 1.000 rs2278218 chr10:79680399 G/A cg17075019 chr10:79541650 NA -0.76 -9.43 -0.5 2.22e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9303401 0.704 rs740605 chr17:56604811 C/T cg12560992 chr17:57184187 TRIM37 0.57 7.24 0.41 4.75e-12 Cognitive test performance; CESC cis rs7589342 0.839 rs1465639 chr2:106439181 T/C cg16077055 chr2:106428750 NCK2 0.48 6.88 0.39 4.33e-11 Addiction; CESC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg05025164 chr4:1340916 KIAA1530 0.42 5.72 0.33 2.82e-8 Longevity; CESC trans rs561341 0.709 rs8068049 chr17:30183857 T/C cg20587970 chr11:113659929 NA 1.01 10.34 0.54 2.85e-21 Hip circumference adjusted for BMI; CESC cis rs9457247 1.000 rs2769352 chr6:167378619 A/G cg25258033 chr6:167368657 RNASET2 -0.4 -6.11 -0.35 3.49e-9 Crohn's disease; CESC cis rs7666738 0.830 rs28451001 chr4:98924544 T/A cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg00999950 chr4:99064541 C4orf37 0.4 5.13 0.3 5.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4843747 0.697 rs72818533 chr16:88073841 G/A cg06374794 chr16:88002281 BANP 0.41 5.3 0.31 2.42e-7 Menopause (age at onset); CESC cis rs889312 0.500 rs832566 chr5:56151744 C/T cg14703610 chr5:56206110 C5orf35 0.48 6.34 0.36 9.93e-10 Breast cancer;Breast cancer (early onset); CESC cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg06544989 chr22:39130855 UNC84B 0.52 8.93 0.48 7.46e-17 Menopause (age at onset); CESC cis rs62064224 0.638 rs9748130 chr17:30739113 A/G cg18200150 chr17:30822561 MYO1D 0.4 5.18 0.3 4.45e-7 Schizophrenia; CESC cis rs9287719 0.837 rs4233883 chr2:10755596 A/G cg00105475 chr2:10696890 NA 0.38 5.44 0.32 1.23e-7 Prostate cancer; CESC cis rs9911578 1.000 rs1472288 chr17:56910720 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 3.04e-7 Intelligence (multi-trait analysis); CESC cis rs4253772 0.591 rs73886791 chr22:46687212 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.76 8.8 0.48 1.8e-16 LDL cholesterol;Cholesterol, total; CESC cis rs7223966 1.000 rs11658740 chr17:61751069 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.69 0.38 1.33e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7769051 0.522 rs6934155 chr6:133124021 C/T cg22852734 chr6:133119734 C6orf192 1.06 7.13 0.4 9.46e-12 Type 2 diabetes nephropathy; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17966709 chr11:57435952 ZDHHC5 0.47 6.48 0.37 4.52e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs796364 0.806 rs6435040 chr2:200861161 T/G cg23649088 chr2:200775458 C2orf69 0.59 5.34 0.31 1.95e-7 Schizophrenia; CESC cis rs9914988 0.943 rs1035989 chr17:27143810 T/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs7216064 1.000 rs62084208 chr17:65827443 C/T cg12091567 chr17:66097778 LOC651250 -0.85 -8.46 -0.46 1.79e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11098499 0.562 rs2389879 chr4:120557684 G/A cg25214090 chr10:38739885 LOC399744 -0.57 -8.01 -0.44 3.6e-14 Corneal astigmatism; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09267708 chr1:155883625 KIAA0907 -0.43 -6.17 -0.35 2.53e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs62064224 0.702 rs2302277 chr17:30791509 C/G cg18200150 chr17:30822561 MYO1D 0.72 11.31 0.57 1.8e-24 Schizophrenia; CESC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg25517755 chr10:38738941 LOC399744 -0.49 -6.35 -0.36 9.08e-10 Extrinsic epigenetic age acceleration; CESC cis rs3126085 0.825 rs868303 chr1:152178563 C/A cg26876637 chr1:152193138 HRNR 0.48 5.5 0.32 8.93e-8 Atopic dermatitis; CESC cis rs9875589 0.509 rs2731337 chr3:14091440 G/C cg19554555 chr3:13937349 NA -0.45 -5.85 -0.34 1.41e-8 Ovarian reserve; CESC cis rs7394190 0.748 rs2306327 chr10:75573778 A/T cg07699608 chr10:75541558 CHCHD1 0.58 5.07 0.3 7.41e-7 Incident atrial fibrillation; CESC cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg05347473 chr6:146136440 FBXO30 -0.56 -7.08 -0.4 1.26e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs11792861 0.926 rs59904140 chr9:111910051 C/T cg05043794 chr9:111880884 C9orf5 -0.39 -6.41 -0.37 6.65e-10 Menarche (age at onset); CESC cis rs854765 0.583 rs10048206 chr17:17866897 A/G cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC cis rs453301 0.571 rs2929454 chr8:9083854 A/C cg15556689 chr8:8085844 FLJ10661 -0.52 -6.52 -0.37 3.6e-10 Joint mobility (Beighton score); CESC cis rs11650494 0.710 rs76305536 chr17:47488913 G/A cg08112188 chr17:47440006 ZNF652 1.12 7.22 0.41 5.4e-12 Prostate cancer; CESC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg08736216 chr1:53307985 ZYG11A -0.37 -6.27 -0.36 1.45e-9 Monocyte count; CESC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg05585544 chr11:47624801 NA 0.41 6.14 0.35 3.01e-9 Subjective well-being; CESC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg04315214 chr1:2043799 PRKCZ 0.6 10.26 0.53 5.16e-21 Height; CESC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs113835537 0.529 rs11227501 chr11:66274072 T/C cg24851651 chr11:66362959 CCS 0.43 5.39 0.31 1.52e-7 Airway imaging phenotypes; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg10166735 chr16:1570449 IFT140 0.37 6.03 0.35 5.62e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg11301795 chr4:187892539 NA -0.75 -11.96 -0.59 1.2e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg01939980 chr4:1354348 KIAA1530 0.38 5.07 0.3 7.48e-7 Longevity; CESC cis rs208520 0.789 rs9351549 chr6:66871851 A/G cg07460842 chr6:66804631 NA -0.99 -13.04 -0.63 2.24e-30 Exhaled nitric oxide output; CESC cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.79 8.79 0.47 1.98e-16 Alzheimer's disease; CESC cis rs12477438 0.798 rs9679602 chr2:99577827 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.7 10.3 0.53 3.91e-21 Chronic sinus infection; CESC trans rs4596713 0.507 rs10115134 chr9:71800562 T/C cg16512924 chr15:28394682 HERC2 0.48 6.13 0.35 3.2e-9 Headache; CESC cis rs4268898 1.000 rs6746005 chr2:24434345 G/A cg06627628 chr2:24431161 ITSN2 0.63 7.39 0.41 1.89e-12 Asthma; CESC cis rs5758659 0.652 rs5751195 chr22:42380001 A/C cg15557168 chr22:42548783 NA -0.42 -6.17 -0.35 2.61e-9 Cognitive function; CESC cis rs2415984 0.562 rs61991051 chr14:46904538 C/A cg14871534 chr14:47121158 RPL10L 0.43 6.07 0.35 4.41e-9 Number of children ever born; CESC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg11764359 chr7:65958608 NA -0.66 -8.43 -0.46 2.25e-15 Aortic root size; CESC cis rs10979 1.000 rs9403506 chr6:143887805 C/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.21 -0.49 1.04e-17 Hypospadias; CESC trans rs61931739 1.000 rs12427279 chr12:34025898 T/G cg26384229 chr12:38710491 ALG10B -0.46 -6.14 -0.35 2.98e-9 Morning vs. evening chronotype; CESC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg19163074 chr7:65112434 INTS4L2 -0.46 -5.93 -0.34 9.36e-9 Aortic root size; CESC cis rs7210086 0.948 rs72849451 chr17:70638565 C/T cg04206342 chr17:70636940 NA -0.35 -6.01 -0.35 6.05e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01849260 chr5:77072153 TBCA 0.55 6.22 0.36 1.93e-9 Gut microbiome composition (summer); CESC cis rs2404602 0.647 rs36114653 chr15:77025393 G/A cg23625390 chr15:77176239 SCAPER -0.39 -5.12 -0.3 5.75e-7 Blood metabolite levels; CESC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg11366901 chr6:160182831 ACAT2 0.83 10.41 0.54 1.65e-21 Age-related macular degeneration (geographic atrophy); CESC cis rs963731 0.649 rs4670905 chr2:39266134 A/T cg04010122 chr2:39346883 SOS1 -0.72 -5.23 -0.31 3.38e-7 Corticobasal degeneration; CESC cis rs12893668 0.638 rs11851616 chr14:104065600 G/A cg08213375 chr14:104286397 PPP1R13B 0.33 5.18 0.3 4.43e-7 Reticulocyte count; CESC cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.03e-7 Colorectal cancer; CESC trans rs35110281 0.712 rs167930 chr21:44946625 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.62 0.38 1.94e-10 Mean corpuscular volume; CESC cis rs9359856 0.564 rs72915933 chr6:90441464 C/T cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.52 -0.37 3.51e-10 Bipolar disorder; CESC cis rs6964587 1.000 rs6944591 chr7:91642714 T/C cg17063962 chr7:91808500 NA 0.56 7.76 0.43 1.79e-13 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00556029 chr1:32802033 MARCKSL1 -0.55 -7.32 -0.41 3.02e-12 Gut microbiota (bacterial taxa); CESC cis rs7582720 1.000 rs115654617 chr2:203893999 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg24675658 chr1:53192096 ZYG11B -0.66 -9.13 -0.49 1.78e-17 Monocyte count; CESC cis rs250677 0.687 rs36043 chr5:148440983 G/A cg18129178 chr5:148520854 ABLIM3 -0.5 -5.79 -0.34 1.98e-8 Breast cancer; CESC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg18301423 chr5:131593218 PDLIM4 0.38 5.42 0.32 1.32e-7 Breast cancer; CESC cis rs7927592 0.913 rs12284933 chr11:68319489 G/A cg20283391 chr11:68216788 NA -0.61 -7.36 -0.41 2.26e-12 Total body bone mineral density; CESC cis rs11958404 0.932 rs6859470 chr5:157429505 T/G cg05962755 chr5:157440814 NA 0.62 6.53 0.37 3.41e-10 IgG glycosylation; CESC cis rs7225537 0.532 rs11551189 chr17:17062241 C/G cg20098446 chr17:17120238 FLCN 0.33 5.14 0.3 5.4e-7 Mean platelet volume; CESC cis rs7772486 0.875 rs9403763 chr6:146357655 A/G cg05347473 chr6:146136440 FBXO30 0.5 6.51 0.37 3.72e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs17376456 0.877 rs10063045 chr5:93457584 A/T cg21475434 chr5:93447410 FAM172A 0.9 7.47 0.42 1.18e-12 Diabetic retinopathy; CESC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg09127314 chr1:152161683 NA 0.4 5.16 0.3 4.81e-7 Inflammatory skin disease; CESC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg18538332 chr22:24372958 LOC391322 -0.66 -9.82 -0.52 1.3e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12603476 chr10:82214649 TSPAN14 0.62 6.94 0.39 2.94e-11 Gut microbiome composition (summer); CESC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg18446336 chr7:2847575 GNA12 -0.36 -5.47 -0.32 1.03e-7 Height; CESC cis rs7666738 0.546 rs13149516 chr4:98913030 T/A cg05340658 chr4:99064831 C4orf37 0.6 7.49 0.42 1.06e-12 Colonoscopy-negative controls vs population controls; CESC trans rs561341 1.000 rs15654 chr17:30326360 A/C cg20587970 chr11:113659929 NA -1.44 -18.71 -0.75 2.25e-50 Hip circumference adjusted for BMI; CESC cis rs453301 0.598 rs2921383 chr8:8892221 C/T cg06636001 chr8:8085503 FLJ10661 0.47 5.92 0.34 9.75e-9 Joint mobility (Beighton score); CESC cis rs360798 0.512 rs1906198 chr2:62946658 C/T cg17519650 chr2:63277830 OTX1 0.48 6.01 0.35 5.97e-9 Coronary artery disease; CESC cis rs4555082 0.834 rs4412909 chr14:105759226 T/C cg13114125 chr14:105738426 BRF1 -0.89 -10.98 -0.56 2.32e-23 Mean platelet volume;Platelet distribution width; CESC cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs748404 0.660 rs542898 chr15:43719392 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.55 0.42 7.19e-13 Lung cancer; CESC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg24101359 chr6:42928495 GNMT 0.61 9.62 0.51 5.66e-19 Alzheimer's disease in APOE e4+ carriers; CESC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg23978390 chr7:1156363 C7orf50 0.42 5.56 0.32 6.5e-8 Longevity;Endometriosis; CESC cis rs12464483 0.591 rs72800120 chr2:30897122 G/A cg07150166 chr2:30669952 LCLAT1 0.56 5.51 0.32 8.59e-8 Pre-treatment pain in head and neck squamous cell carcinoma; CESC cis rs4780401 0.703 rs7193637 chr16:11764920 C/T cg01061890 chr16:11836724 TXNDC11 -0.4 -5.17 -0.3 4.64e-7 Rheumatoid arthritis; CESC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.4 5.33 0.31 2.06e-7 Bipolar disorder; CESC trans rs11098499 0.866 rs6847778 chr4:120293582 A/G cg25214090 chr10:38739885 LOC399744 0.66 9.17 0.49 1.35e-17 Corneal astigmatism; CESC cis rs6460942 1.000 rs62448566 chr7:12403662 G/A cg17427002 chr7:12443146 VWDE -0.52 -5.27 -0.31 2.82e-7 Coronary artery disease; CESC cis rs10088262 0.629 rs12541177 chr8:124800273 G/T cg02993010 chr8:124780839 FAM91A1 -0.67 -8.55 -0.46 1.01e-15 Pancreatic cancer; CESC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg06108461 chr20:60628389 TAF4 -0.93 -14.44 -0.66 2.89e-35 Body mass index; CESC cis rs1475911 1.000 rs2839466 chr21:43512324 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 -0.55 -6.37 -0.36 8.35e-10 IgG glycosylation; CESC cis rs854765 0.583 rs7213225 chr17:17869111 T/C cg09796270 chr17:17721594 SREBF1 0.45 6.17 0.35 2.61e-9 Total body bone mineral density; CESC cis rs2710642 0.611 rs1534418 chr2:62883920 A/G cg17519650 chr2:63277830 OTX1 -0.49 -5.86 -0.34 1.37e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs56104184 0.779 rs17272666 chr19:49356294 T/C cg15549821 chr19:49342101 PLEKHA4 -0.8 -9.11 -0.49 2.04e-17 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7264396 0.623 rs78949029 chr20:34384964 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.66 6.57 0.37 2.65e-10 Total cholesterol levels; CESC cis rs7524258 0.868 rs4908607 chr1:7269323 A/G cg07173049 chr1:7289937 CAMTA1 0.4 6.06 0.35 4.56e-9 Tourette's syndrome or obsessive-compulsive disorder; CESC trans rs875971 0.895 rs4718349 chr7:65909011 C/G cg26939375 chr7:64535504 NA 0.47 6.04 0.35 5.27e-9 Aortic root size; CESC cis rs782590 0.748 rs782634 chr2:55897700 T/C cg18811423 chr2:55921094 PNPT1 0.77 12.5 0.61 1.74e-28 Metabolic syndrome; CESC cis rs1461503 0.966 rs10892937 chr11:122841904 T/C cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs9487051 0.621 rs351722 chr6:109550939 A/G cg01475377 chr6:109611718 NA -0.38 -5.14 -0.3 5.22e-7 Reticulocyte fraction of red cells; CESC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.55 0.37 2.95e-10 Bipolar disorder; CESC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg27121462 chr16:89883253 FANCA 0.75 10.79 0.55 9.94e-23 Vitiligo; CESC cis rs3126085 0.935 rs1552995 chr1:152171427 A/G cg26876637 chr1:152193138 HRNR 0.45 5.18 0.3 4.29e-7 Atopic dermatitis; CESC cis rs7224685 0.501 rs11649992 chr17:4026823 A/G cg07607921 chr17:4047574 ZZEF1;CYB5D2 0.49 5.09 0.3 6.96e-7 Type 2 diabetes; CESC cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg02487422 chr3:49467188 NICN1 0.4 5.15 0.3 5.11e-7 Parkinson's disease; CESC cis rs6912958 0.781 rs9450755 chr6:88303702 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.56 -0.37 2.82e-10 Monocyte percentage of white cells; CESC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg08704250 chr15:31115839 NA -0.63 -8.06 -0.44 2.6e-14 Huntington's disease progression; CESC cis rs12971120 0.891 rs3794953 chr18:72180519 C/T cg25817165 chr18:72167213 CNDP2 -0.61 -7.27 -0.41 3.94e-12 Refractive error; CESC trans rs4741343 0.752 rs723968 chr9:14154231 T/C cg03691418 chr17:80962847 B3GNTL1 -0.58 -6.09 -0.35 3.91e-9 Educational attainment (years of education); CESC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg23708337 chr7:1209742 NA 0.52 5.14 0.3 5.37e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg14347670 chr6:41908995 CCND3 0.47 6.14 0.35 2.96e-9 Tetralogy of Fallot; CESC cis rs10242455 0.571 rs117370443 chr7:98975258 T/C cg18809830 chr7:99032528 PTCD1 -0.73 -5.28 -0.31 2.71e-7 Blood metabolite levels; CESC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg03576123 chr11:487126 PTDSS2 -1.08 -10.51 -0.54 7.9e-22 Body mass index; CESC cis rs12681288 0.550 rs72507624 chr8:961324 G/A cg04851639 chr8:1020857 NA -0.32 -6.12 -0.35 3.33e-9 Schizophrenia; CESC cis rs66887589 0.616 rs7659403 chr4:120207254 T/A cg09307838 chr4:120376055 NA 0.68 9.52 0.5 1.13e-18 Diastolic blood pressure; CESC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg06494592 chr3:125709126 NA -0.49 -5.23 -0.31 3.48e-7 Blood pressure (smoking interaction); CESC cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg24110177 chr3:50126178 RBM5 -0.61 -8.72 -0.47 3.07e-16 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11310125 chr2:113239311 TTL 0.61 7.34 0.41 2.66e-12 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg20151795 chr6:28129481 ZNF389 0.45 5.84 0.34 1.5e-8 Depression; CESC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg05872129 chr22:39784769 NA 0.81 10.76 0.55 1.25e-22 Intelligence (multi-trait analysis); CESC trans rs561341 1.000 rs56903735 chr17:30254393 T/A cg20587970 chr11:113659929 NA -1.11 -13.56 -0.64 3.64e-32 Hip circumference adjusted for BMI; CESC cis rs9660992 0.762 rs1668871 chr1:205237137 T/C cg00857998 chr1:205179979 DSTYK 0.43 5.24 0.31 3.28e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs12971120 0.891 rs2303463 chr18:72168608 G/A cg25817165 chr18:72167213 CNDP2 -0.58 -7.09 -0.4 1.22e-11 Refractive error; CESC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg07701084 chr6:150067640 NUP43 0.43 5.95 0.34 8.47e-9 Lung cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24156658 chr11:65122092 TIGD3 -0.45 -6.44 -0.37 5.56e-10 Asthma; CESC cis rs10838687 0.673 rs59567949 chr11:47300155 G/A cg25783544 chr11:47291846 MADD 0.56 6.52 0.37 3.53e-10 Proinsulin levels; CESC cis rs4699052 0.963 rs4699057 chr4:104171123 A/G cg16532752 chr4:104119610 CENPE 0.44 6.15 0.35 2.82e-9 Testicular germ cell tumor; CESC cis rs9309473 0.607 rs7567017 chr2:73596270 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -6.56 -0.37 2.84e-10 Metabolite levels; CESC cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 -0.36 -5.82 -0.34 1.66e-8 Hip circumference adjusted for BMI; CESC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg07507251 chr3:52567010 NT5DC2 0.32 5.5 0.32 8.74e-8 Bipolar disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16520737 chr19:1021368 C19orf6 -0.46 -6.18 -0.35 2.39e-9 Gut microbiota (bacterial taxa); CESC cis rs4664308 0.935 rs4637057 chr2:160950161 G/T cg03641300 chr2:160917029 PLA2R1 -0.67 -9.84 -0.52 1.11e-19 Idiopathic membranous nephropathy; CESC cis rs7605827 0.897 rs10202600 chr2:15514461 T/C cg19274914 chr2:15703543 NA 0.32 5.55 0.32 6.84e-8 Educational attainment (years of education); CESC cis rs11098499 0.738 rs10026493 chr4:120384194 C/G cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.05e-8 Corneal astigmatism; CESC cis rs10242455 0.867 rs2404769 chr7:99321716 T/C cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs4948102 0.961 rs7776550 chr7:56092391 T/C cg09872392 chr7:56161020 PHKG1 -0.43 -6.46 -0.37 5.11e-10 Plasma homocysteine levels (post-methionine load test); CESC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg05863683 chr7:1912471 MAD1L1 0.48 7.35 0.41 2.39e-12 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg03676636 chr4:99064102 C4orf37 0.35 5.23 0.31 3.46e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3820928 0.874 rs13393902 chr2:227880554 A/G cg11843606 chr2:227700838 RHBDD1 -0.46 -6.09 -0.35 3.87e-9 Pulmonary function; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02576092 chr1:27668556 SYTL1 0.44 6.04 0.35 5.27e-9 Systemic lupus erythematosus; CESC cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg12373951 chr3:133503437 NA 0.37 5.09 0.3 6.7e-7 Iron status biomarkers; CESC cis rs13191362 0.810 rs13209784 chr6:162961274 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 7.66 0.43 3.52e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs5769765 0.908 rs9616213 chr22:50317851 T/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.63 -6.44 -0.37 5.53e-10 Schizophrenia; CESC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC trans rs9951602 0.512 rs12607938 chr18:76651887 A/C cg02800362 chr5:177631904 HNRNPAB 0.61 8.34 0.46 4.07e-15 Obesity-related traits; CESC cis rs2120019 0.938 rs8033925 chr15:75311959 A/G cg09165964 chr15:75287851 SCAMP5 -0.77 -9.82 -0.52 1.29e-19 Blood trace element (Zn levels); CESC cis rs7044106 0.791 rs10985001 chr9:123484232 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.3 0.53 3.82e-21 Hip circumference adjusted for BMI; CESC cis rs34779708 0.733 rs3936503 chr10:35549257 A/G cg03585969 chr10:35415529 CREM -0.56 -6.85 -0.39 5.01e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs6089584 1.000 rs6089581 chr20:60562394 G/A cg13770153 chr20:60521292 NA -0.45 -5.9 -0.34 1.12e-8 Body mass index; CESC cis rs10504073 0.647 rs10808745 chr8:49989037 G/A cg00325661 chr8:49890786 NA 0.55 8.05 0.44 2.78e-14 Blood metabolite ratios; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16442450 chr15:69111511 ANP32A -0.39 -6.23 -0.36 1.82e-9 Gambling; CESC trans rs10463316 0.894 rs6579863 chr5:150761946 A/T cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs7927592 0.763 rs1193699 chr11:68249480 C/G cg01657329 chr11:68192670 LRP5 -0.45 -5.91 -0.34 1.05e-8 Total body bone mineral density; CESC cis rs6740322 0.895 rs9309098 chr2:43554972 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.69 7.48 0.42 1.11e-12 Coronary artery disease; CESC cis rs920590 0.684 rs59565447 chr8:19668430 A/T cg03894339 chr8:19674705 INTS10 0.68 7.68 0.43 3.04e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs6500395 0.926 rs11643272 chr16:48639723 T/C cg04672837 chr16:48644449 N4BP1 0.5 6.07 0.35 4.3e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg11663144 chr21:46675770 NA -0.51 -7.08 -0.4 1.31e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12458462 0.892 rs2242174 chr18:77458037 T/C cg11879182 chr18:77439856 CTDP1 0.88 13.9 0.65 2.24e-33 Monocyte count; CESC cis rs2625529 0.652 rs2929518 chr15:72332748 A/C cg16672083 chr15:72433130 SENP8 0.44 6.71 0.38 1.18e-10 Red blood cell count; CESC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.94 0.44 5.6e-14 Menopause (age at onset); CESC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg09263875 chr16:632152 PIGQ 0.68 11.67 0.58 1.11e-25 Height; CESC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg22029157 chr1:209979665 IRF6 0.71 10.13 0.53 1.34e-20 Cleft lip with or without cleft palate; CESC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg18016565 chr1:150552671 MCL1 0.33 5.09 0.3 6.65e-7 Melanoma; CESC cis rs6499129 0.867 rs11859352 chr16:67390448 A/G cg26727032 chr16:67993705 SLC12A4 -0.53 -5.83 -0.34 1.57e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.4 5.32 0.31 2.26e-7 Bipolar disorder; CESC cis rs11098499 0.954 rs1546505 chr4:120241224 A/G cg24375607 chr4:120327624 NA 0.44 5.4 0.31 1.49e-7 Corneal astigmatism; CESC cis rs1045714 0.943 rs1045711 chr7:2653571 C/T cg20813462 chr7:2646259 IQCE 0.71 5.79 0.34 1.98e-8 Urate levels in lean individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15487600 chr1:155113158 DPM3 0.61 7.02 0.4 1.9e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13323097 chr1:205649211 SLC45A3 0.57 6.81 0.39 6.52e-11 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg27347728 chr4:17578864 LAP3 0.46 5.48 0.32 9.65e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs55728055 0.661 rs16989274 chr22:31955908 G/A cg01338084 chr22:32026380 PISD 1.26 8.23 0.45 8.74e-15 Age-related hearing impairment; CESC cis rs367943 0.712 rs10062004 chr5:112694914 T/C cg12552261 chr5:112820674 MCC 0.41 5.37 0.31 1.73e-7 Type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16529307 chr1:89990087 LRRC8B -0.52 -6.68 -0.38 1.39e-10 Ulcerative colitis; CESC cis rs360798 0.512 rs12989754 chr2:63020970 A/G cg17519650 chr2:63277830 OTX1 -0.59 -7.79 -0.43 1.49e-13 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11781344 chr5:133706657 UBE2B -0.63 -7.37 -0.41 2.24e-12 Gut microbiome composition (summer); CESC cis rs3809566 1.000 rs4775610 chr15:63332057 C/T cg05507819 chr15:63340323 TPM1 -0.52 -6.37 -0.36 8.15e-10 Platelet count; CESC cis rs13064411 0.696 rs1386336 chr3:113144153 C/T cg18753928 chr3:113234510 CCDC52 -0.45 -5.18 -0.3 4.37e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs6831352 0.918 rs4699713 chr4:100060513 C/T cg13256891 chr4:100009986 ADH5 -0.75 -8.21 -0.45 9.89e-15 Alcohol dependence; CESC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg27165867 chr14:105738592 BRF1 -0.5 -5.44 -0.32 1.23e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7772486 0.875 rs1330939 chr6:146308518 T/A cg23711669 chr6:146136114 FBXO30 0.78 11.25 0.57 2.92e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs3015469 0.671 rs2883951 chr14:51154493 C/T cg26011998 chr14:51135199 SAV1 0.52 5.58 0.32 6.05e-8 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs9747201 1.000 rs9303020 chr17:80163247 C/T cg09264619 chr17:80180166 NA -0.46 -5.43 -0.32 1.29e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9611519 0.929 rs13055800 chr22:41440424 G/A cg03806693 chr22:41940476 POLR3H -0.56 -5.88 -0.34 1.22e-8 Neuroticism; CESC cis rs7512552 0.809 rs1694363 chr1:150368677 T/G cg15654264 chr1:150340011 RPRD2 0.42 5.51 0.32 8.49e-8 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs8114671 0.562 rs4911447 chr20:33479445 T/A cg07148914 chr20:33460835 GGT7 0.45 5.92 0.34 9.9e-9 Height; CESC cis rs79349575 0.687 rs12602179 chr17:47010034 G/T cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs9913156 0.793 rs72835633 chr17:4562643 C/T cg19197139 chr17:4613644 ARRB2 0.92 10.46 0.54 1.18e-21 Lymphocyte counts; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12296079 chr11:61849674 NA 0.49 6.15 0.35 2.85e-9 Gut microbiota (bacterial taxa); CESC cis rs2370759 0.945 rs10508773 chr10:32575444 C/T cg05361325 chr10:32636312 EPC1 -0.55 -5.18 -0.3 4.39e-7 Sexual dysfunction (female); CESC cis rs9611565 0.879 rs5758307 chr22:41750219 A/G cg17376030 chr22:41985996 PMM1 0.43 5.03 0.3 9.17e-7 Vitiligo; CESC cis rs4803468 0.901 rs3745292 chr19:41888506 A/G cg09537434 chr19:41945824 ATP5SL -1.02 -18.21 -0.75 1.31e-48 Height; CESC cis rs7727544 0.735 rs272894 chr5:131662460 C/T cg07395648 chr5:131743802 NA -0.49 -6.5 -0.37 4.07e-10 Blood metabolite levels; CESC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg17221315 chr6:27791827 HIST1H4J 0.63 5.22 0.31 3.65e-7 Depression; CESC cis rs735860 0.726 rs209507 chr6:53194768 T/A cg10236188 chr6:53219634 NA 0.34 5.12 0.3 5.91e-7 Glaucoma; CESC cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg01017244 chr2:74357527 NA 0.68 9.89 0.52 7.68e-20 Gestational age at birth (maternal effect); CESC cis rs568617 0.953 rs658524 chr11:65647260 A/G cg00576331 chr11:65640516 EFEMP2 0.45 5.3 0.31 2.48e-7 Crohn's disease; CESC trans rs875971 1.000 rs1565531 chr7:65663113 T/A cg26939375 chr7:64535504 NA -0.46 -6.09 -0.35 4e-9 Aortic root size; CESC cis rs7264396 1.000 rs6060479 chr20:34165723 A/C cg04508476 chr20:34239394 CPNE1;RBM12 0.54 6.47 0.37 4.67e-10 Total cholesterol levels; CESC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.05 0.3 8.28e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8064299 0.967 rs878907 chr17:72769694 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.64 9.21 0.49 9.94e-18 Monocyte count; CESC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.24 0.76 3.09e-52 Height; CESC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg06456125 chr7:65229604 NA -0.39 -5.09 -0.3 6.82e-7 Aortic root size; CESC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg25036284 chr2:26402008 FAM59B -0.88 -9.99 -0.52 3.79e-20 Gut microbiome composition (summer); CESC cis rs909674 0.734 rs5757675 chr22:39838892 G/T cg05872129 chr22:39784769 NA -0.77 -10.31 -0.54 3.54e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs10078 0.571 rs2721014 chr5:463539 G/A cg08916839 chr5:415575 AHRR 0.58 6.76 0.38 8.54e-11 Fat distribution (HIV); CESC cis rs8060686 0.623 rs7205935 chr16:68152157 A/G cg26727032 chr16:67993705 SLC12A4 -0.59 -8.1 -0.45 2.03e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg07507251 chr3:52567010 NT5DC2 0.41 7.2 0.4 6.38e-12 Bipolar disorder; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg14748682 chr11:6624841 ILK;RRP8 0.49 6.19 0.36 2.23e-9 Breast cancer;Type 2 diabetes; CESC cis rs754466 0.580 rs2289309 chr10:79571108 C/T cg17075019 chr10:79541650 NA -0.87 -13.8 -0.65 5.26e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg11644478 chr21:40555479 PSMG1 -0.84 -12.59 -0.61 8.41e-29 Cognitive function; CESC cis rs11122272 0.735 rs2790881 chr1:231534181 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg11494091 chr17:61959527 GH2 0.74 12.59 0.61 8.53e-29 Prudent dietary pattern; CESC trans rs2693676 0.504 rs1257491 chr14:99603939 T/C cg17465227 chr4:47427752 GABRB1 0.55 6.25 0.36 1.68e-9 Corneal curvature; CESC cis rs977987 0.806 rs12930768 chr16:75464500 T/C cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg11752832 chr7:134001865 SLC35B4 0.5 5.99 0.35 6.84e-9 Mean platelet volume; CESC cis rs910316 1.000 rs2268617 chr14:75608728 G/A cg08847533 chr14:75593920 NEK9 1.0 19.26 0.76 2.69e-52 Height; CESC cis rs1691799 0.899 rs1168351 chr12:66752505 A/G cg16791601 chr12:66731901 HELB -0.78 -13.93 -0.65 1.79e-33 White blood cell count (basophil); CESC cis rs2243480 1.000 rs58062456 chr7:65394852 G/T cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC cis rs17666538 0.585 rs4448252 chr8:615597 A/G cg07234876 chr8:600039 NA 0.81 5.83 0.34 1.62e-8 IgG glycosylation; CESC cis rs8020095 0.706 rs8006552 chr14:67294069 C/G cg19548862 chr14:67692701 FAM71D -0.42 -5.67 -0.33 3.7e-8 Depression (quantitative trait); CESC cis rs10788264 0.504 rs1034533 chr10:124032434 A/G cg09507567 chr10:124027408 NA 0.43 6.0 0.35 6.31e-9 Total body bone mineral density; CESC cis rs4566357 0.615 rs12621808 chr2:227909522 A/C cg05526886 chr2:227700861 RHBDD1 -0.44 -5.74 -0.33 2.57e-8 Coronary artery disease; CESC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 5.97 0.34 7.45e-9 Electroencephalogram traits; CESC cis rs17376456 0.757 rs10066431 chr5:93198204 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 5.05 0.3 8.28e-7 Diabetic retinopathy; CESC cis rs7267979 0.932 rs424487 chr20:25468131 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 14.62 0.67 6.72e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs870825 0.655 rs35764203 chr4:185639078 C/A cg04058563 chr4:185651563 MLF1IP 0.64 7.07 0.4 1.39e-11 Blood protein levels; CESC cis rs2243480 0.522 rs73150635 chr7:65972490 C/T cg13147721 chr7:65941812 NA -0.86 -6.38 -0.36 7.85e-10 Diabetic kidney disease; CESC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg04414720 chr1:150670196 GOLPH3L 0.63 9.04 0.49 3.47e-17 Tonsillectomy; CESC cis rs12410462 0.681 rs6670816 chr1:227610592 G/T cg04117972 chr1:227635322 NA -0.73 -6.9 -0.39 3.72e-11 Major depressive disorder; CESC cis rs2658782 0.789 rs3020076 chr11:93141058 C/T cg15737290 chr11:93063684 CCDC67 0.48 5.83 0.34 1.61e-8 Pulmonary function decline; CESC cis rs477692 0.612 rs58103386 chr10:131319958 C/A cg05714579 chr10:131428358 MGMT 0.41 5.36 0.31 1.83e-7 Response to temozolomide; CESC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg26441486 chr22:50317300 CRELD2 0.42 5.24 0.31 3.33e-7 Schizophrenia; CESC cis rs4555082 0.957 rs2735818 chr14:105714751 A/G cg13114125 chr14:105738426 BRF1 -0.68 -8.41 -0.46 2.62e-15 Mean platelet volume;Platelet distribution width; CESC cis rs3096299 0.874 rs3102342 chr16:89451575 T/C cg02187348 chr16:89574699 SPG7 0.55 7.34 0.41 2.64e-12 Multiple myeloma (IgH translocation); CESC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg12463550 chr7:65579703 CRCP 0.59 7.54 0.42 7.73e-13 Aortic root size; CESC cis rs1577917 0.771 rs7742201 chr6:86432930 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -7.92 -0.44 6.58e-14 Response to antipsychotic treatment; CESC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg16325326 chr1:53192061 ZYG11B -0.9 -15.35 -0.69 1.76e-38 Monocyte count; CESC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg26335602 chr6:28129616 ZNF389 0.54 7.14 0.4 8.92e-12 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06891939 chr7:56950307 NA -0.56 -6.6 -0.38 2.19e-10 Gut microbiome composition (summer); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04100724 chr12:92539208 BTG1 -0.48 -6.65 -0.38 1.7e-10 Height; CESC cis rs1005224 0.895 rs11624114 chr14:76131800 A/G cg25116370 chr14:76127843 TTLL5;C14orf1 -0.4 -5.36 -0.31 1.78e-7 Large artery stroke; CESC cis rs7772486 0.790 rs9497425 chr6:146234197 G/A cg23711669 chr6:146136114 FBXO30 -0.82 -11.64 -0.58 1.47e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs9581857 0.725 rs1924074 chr13:28015387 C/G cg22138327 chr13:27999177 GTF3A -0.67 -5.42 -0.32 1.36e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs74781061 1.000 rs11072488 chr15:74786358 T/C cg17294928 chr15:75287854 SCAMP5 -0.47 -5.04 -0.3 8.43e-7 Endometriosis; CESC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Parkinson's disease; CESC cis rs4699052 0.590 rs28728298 chr4:104282850 A/T cg16532752 chr4:104119610 CENPE -0.37 -5.3 -0.31 2.46e-7 Testicular germ cell tumor; CESC cis rs28386778 0.965 rs2854154 chr17:61981696 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.69 -9.37 -0.5 3.23e-18 Prudent dietary pattern; CESC cis rs78707713 0.841 rs12242391 chr10:71201504 C/T cg12610070 chr10:71211762 TSPAN15 -0.41 -7.22 -0.41 5.39e-12 Venous thromboembolism; CESC cis rs34330 0.562 rs11055024 chr12:12858969 A/G cg09462578 chr12:12878428 APOLD1 -0.79 -8.49 -0.46 1.48e-15 Systemic lupus erythematosus; CESC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg21951975 chr1:209979733 IRF6 0.6 9.55 0.51 9.28e-19 Cleft lip with or without cleft palate; CESC cis rs28374715 0.681 rs7162231 chr15:41591859 G/A cg20272979 chr15:41787780 ITPKA 0.43 5.17 0.3 4.65e-7 Ulcerative colitis; CESC cis rs2380220 0.606 rs4559095 chr6:95994154 A/C cg04719120 chr6:96025338 MANEA 0.46 5.21 0.3 3.88e-7 Behavioural disinhibition (generation interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10826053 chr4:108641834 PAPSS1 -0.59 -6.71 -0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs10754283 0.934 rs7529653 chr1:90111851 G/A cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7827545 0.545 rs4909477 chr8:135562976 A/G cg17885191 chr8:135476712 NA 0.57 6.1 0.35 3.79e-9 Hypertension (SNP x SNP interaction); CESC trans rs73198271 0.640 rs7838012 chr8:8656630 A/G cg23754772 chr18:12253859 CIDEA -0.34 -6.26 -0.36 1.55e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1707322 0.752 rs4660880 chr1:46111040 C/T cg05343316 chr1:45956843 TESK2 0.51 6.27 0.36 1.49e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8050907 0.744 rs1345430 chr16:4527961 G/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg07414643 chr4:187882934 NA 0.53 7.37 0.41 2.15e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs55883249 1.000 rs62119423 chr2:9726601 C/T cg23886495 chr2:9695866 ADAM17 0.6 5.6 0.33 5.39e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21397993 chr1:243418055 CEP170;SDCCAG8 0.55 6.13 0.35 3.19e-9 Gut microbiome composition (summer); CESC cis rs40363 0.720 rs4453493 chr16:3533881 T/C cg21433313 chr16:3507492 NAT15 -0.56 -8.71 -0.47 3.39e-16 Tuberculosis; CESC cis rs11764590 0.724 rs55669426 chr7:2090129 G/C cg21782813 chr7:2030301 MAD1L1 -0.41 -5.26 -0.31 2.9e-7 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02993890 chr14:50087996 RPL36AL;MGAT2 0.55 6.09 0.35 3.87e-9 Gut microbiome composition (summer); CESC cis rs6968419 0.755 rs6948556 chr7:115895433 T/C cg02561103 chr7:115862891 TES -0.41 -5.33 -0.31 2.13e-7 Intraocular pressure; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07869135 chr8:123794843 ZHX2 0.47 6.05 0.35 4.91e-9 Systemic lupus erythematosus; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg04091837 chr21:47809310 PCNT 0.42 6.13 0.35 3.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2637266 0.935 rs2579774 chr10:78402253 T/C cg18941641 chr10:78392320 NA 0.45 8.65 0.47 4.9e-16 Pulmonary function; CESC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg26839252 chr6:160211577 TCP1;MRPL18 0.46 5.26 0.31 3.04e-7 Age-related macular degeneration (geographic atrophy); CESC trans rs11098499 0.754 rs12711071 chr4:120240934 A/G cg25214090 chr10:38739885 LOC399744 0.57 7.73 0.43 2.3e-13 Corneal astigmatism; CESC cis rs8072100 0.607 rs9894594 chr17:45461383 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -5.42 -0.32 1.36e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs727505 1.000 rs67939974 chr7:124554364 C/T cg23710748 chr7:124431027 NA -0.48 -7.38 -0.41 2.09e-12 Lewy body disease; CESC cis rs4237845 0.591 rs4760344 chr12:58320783 A/T cg02175503 chr12:58329896 NA 0.8 10.69 0.55 2e-22 Intelligence (multi-trait analysis); CESC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg21285383 chr16:89894308 SPIRE2 0.33 5.82 0.34 1.73e-8 Vitiligo; CESC cis rs6582630 0.599 rs8175936 chr12:38426315 C/G cg26384229 chr12:38710491 ALG10B -0.44 -5.95 -0.34 8.28e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg24531977 chr5:56204891 C5orf35 -0.67 -9.38 -0.5 3.04e-18 Initial pursuit acceleration; CESC trans rs2717463 0.639 rs4399374 chr12:80814828 A/G cg08548409 chr3:61550635 PTPRG 0.77 6.27 0.36 1.48e-9 Positive affect; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05922971 chr5:43121458 ZNF131 -0.46 -6.13 -0.35 3.18e-9 Ulcerative colitis; CESC cis rs3857067 0.806 rs17302300 chr4:95109177 T/C cg11021082 chr4:95130006 SMARCAD1 -0.59 -8.92 -0.48 7.87e-17 QT interval; CESC trans rs561341 1.000 rs7216102 chr17:30259450 A/G cg27661571 chr11:113659931 NA -0.53 -6.04 -0.35 5.29e-9 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg26338869 chr17:61819248 STRADA 0.7 9.26 0.49 7.46e-18 Prudent dietary pattern; CESC cis rs66569888 0.754 rs6719028 chr2:106895212 T/C cg16099169 chr2:106886729 NA 0.71 8.71 0.47 3.26e-16 Facial morphology (factor 23); CESC cis rs17401966 1.000 rs35837142 chr1:10322358 C/G cg15208524 chr1:10270712 KIF1B 0.5 6.47 0.37 4.65e-10 Hepatocellular carcinoma; CESC cis rs1847202 0.859 rs7634316 chr3:72941452 C/G cg25664220 chr3:72788482 NA 0.41 5.84 0.34 1.5e-8 Motion sickness; CESC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg12463550 chr7:65579703 CRCP -0.47 -5.96 -0.34 7.88e-9 Aortic root size; CESC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg22442454 chr1:209979470 IRF6 0.51 6.28 0.36 1.38e-9 Cleft lip with or without cleft palate; CESC cis rs7726839 0.540 rs3749618 chr5:602650 A/G cg16447950 chr5:562315 NA -0.58 -6.02 -0.35 5.91e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09426994 chr11:118478258 PHLDB1 0.55 6.29 0.36 1.29e-9 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00560284 chr12:49783222 SPATS2 -0.67 -7.57 -0.42 6.17e-13 Gut microbiome composition (summer); CESC cis rs7408868 0.908 rs45591935 chr19:15277006 T/C cg14696996 chr19:15285081 NOTCH3 1.11 11.48 0.58 4.81e-25 Pulse pressure; CESC cis rs7219021 0.739 rs4793993 chr17:47008546 C/T cg16584676 chr17:46985605 UBE2Z -0.61 -6.92 -0.39 3.46e-11 Schizophrenia or bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04284535 chr17:41624145 ETV4 -0.59 -7.02 -0.4 1.86e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs9831754 1.000 rs3946823 chr3:78353052 G/A cg06138941 chr3:78371609 NA -0.75 -8.54 -0.46 1.09e-15 Calcium levels; CESC cis rs9911578 1.000 rs12453459 chr17:56624291 C/T cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.5e-11 Intelligence (multi-trait analysis); CESC cis rs3857067 1.000 rs3846291 chr4:95026735 A/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -7.99 -0.44 4.19e-14 QT interval; CESC cis rs1728785 1.000 rs8058145 chr16:68584090 G/A cg02972257 chr16:68554789 NA -0.54 -6.27 -0.36 1.45e-9 Ulcerative colitis; CESC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg07936489 chr17:37558343 FBXL20 -0.81 -11.7 -0.58 9.17e-26 Glomerular filtration rate (creatinine); CESC cis rs8141529 0.748 rs5997412 chr22:29276747 G/A cg15103426 chr22:29168792 CCDC117 0.6 7.59 0.42 5.42e-13 Lymphocyte counts; CESC cis rs10979 0.597 rs9496687 chr6:143908815 A/G cg25407410 chr6:143891975 LOC285740 -0.53 -6.93 -0.39 3.25e-11 Hypospadias; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03338968 chr1:3731507 KIAA0562 -0.48 -6.03 -0.35 5.58e-9 Gut microbiome composition (summer); CESC cis rs921968 0.541 rs687747 chr2:219399627 T/C cg02176678 chr2:219576539 TTLL4 0.5 9.0 0.48 4.36e-17 Mean corpuscular hemoglobin concentration; CESC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg11764359 chr7:65958608 NA -0.94 -15.28 -0.68 3.2e-38 Aortic root size; CESC cis rs7219021 0.886 rs9897440 chr17:46868142 C/G cg16584676 chr17:46985605 UBE2Z -0.57 -6.6 -0.38 2.17e-10 Schizophrenia or bipolar disorder; CESC cis rs6964587 0.869 rs13237856 chr7:91551788 G/A cg01689657 chr7:91764605 CYP51A1 -0.29 -5.17 -0.3 4.57e-7 Breast cancer; CESC cis rs113835537 0.529 rs116867234 chr11:66209024 C/T cg22134325 chr11:66188745 NPAS4 0.44 6.7 0.38 1.22e-10 Airway imaging phenotypes; CESC cis rs939574 0.790 rs79225383 chr2:220093972 C/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.88 7.38 0.41 2e-12 Platelet distribution width; CESC cis rs3008870 1.000 rs1925408 chr1:67365034 C/T cg02640540 chr1:67518911 SLC35D1 0.48 5.12 0.3 5.81e-7 Lymphocyte percentage of white cells; CESC trans rs2727020 0.587 rs1164658 chr11:49298551 C/A cg15704280 chr7:45808275 SEPT13 0.87 14.55 0.67 1.19e-35 Coronary artery disease; CESC cis rs7914558 1.000 rs10883826 chr10:104830819 A/G cg04362960 chr10:104952993 NT5C2 0.46 6.16 0.35 2.62e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs11583043 1.000 rs3861734 chr1:101489461 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.63 0.33 4.65e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs6060717 0.536 rs6060664 chr20:34478884 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.7 0.33 3.16e-8 Hip circumference adjusted for BMI; CESC cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg06697600 chr4:7070879 GRPEL1 0.53 6.48 0.37 4.39e-10 Monocyte percentage of white cells; CESC cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg03676636 chr4:99064102 C4orf37 0.34 5.1 0.3 6.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.77 9.43 0.5 2.1e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg01475377 chr6:109611718 NA -0.52 -8.56 -0.47 9.05e-16 Reticulocyte fraction of red cells; CESC cis rs453301 0.686 rs3895823 chr8:8873646 T/C cg15556689 chr8:8085844 FLJ10661 -0.47 -5.62 -0.33 4.95e-8 Joint mobility (Beighton score); CESC cis rs12477438 0.501 rs2516833 chr2:99777405 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.84 0.62 1.16e-29 Chronic sinus infection; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26913791 chr1:47134196 ATPAF1 -0.5 -6.37 -0.36 8.16e-10 Ulcerative colitis; CESC cis rs11690935 0.632 rs11690807 chr2:172628120 G/A cg13550731 chr2:172543902 DYNC1I2 0.62 8.72 0.47 3.14e-16 Schizophrenia; CESC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg08888203 chr3:10149979 C3orf24 0.47 5.91 0.34 1.05e-8 Alzheimer's disease; CESC cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg23711669 chr6:146136114 FBXO30 0.98 15.12 0.68 1.11e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs9457247 0.935 rs1187530 chr6:167376812 C/T cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.62e-7 Crohn's disease; CESC cis rs7914558 0.901 rs35525740 chr10:104941112 A/T cg04362960 chr10:104952993 NT5C2 0.47 6.21 0.36 2.01e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg11843238 chr5:131593191 PDLIM4 0.36 5.21 0.31 3.71e-7 Breast cancer; CESC cis rs7512552 0.809 rs2794679 chr1:150324857 G/A cg15654264 chr1:150340011 RPRD2 0.39 5.24 0.31 3.25e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs4006360 0.505 rs8067313 chr17:39290306 G/T cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.4 -5.07 -0.3 7.45e-7 Bipolar disorder and schizophrenia; CESC cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 5.82 0.34 1.69e-8 Colorectal cancer; CESC cis rs7582720 1.000 rs72936872 chr2:203790889 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs1493916 0.870 rs1389531 chr18:31386616 C/T cg27147174 chr7:100797783 AP1S1 -0.49 -6.87 -0.39 4.48e-11 Life satisfaction; CESC cis rs10489202 0.632 rs202268 chr1:167927339 T/C cg24449463 chr1:168025552 DCAF6 -0.44 -5.56 -0.32 6.55e-8 Schizophrenia; CESC cis rs7582720 1.000 rs6725887 chr2:203745885 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 -0.85 -7.0 -0.39 2.13e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg09796270 chr17:17721594 SREBF1 0.43 5.84 0.34 1.49e-8 Total body bone mineral density; CESC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.11 19.72 0.77 6.87e-54 Height; CESC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg07507251 chr3:52567010 NT5DC2 0.32 5.56 0.32 6.75e-8 Bipolar disorder; CESC cis rs9902453 0.765 rs3102560 chr17:28029938 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.77 10.47 0.54 1.11e-21 Coffee consumption (cups per day); CESC cis rs2228479 0.850 rs74251570 chr16:89910068 C/A cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs1005224 0.963 rs2302592 chr14:76129287 C/G cg25116370 chr14:76127843 TTLL5;C14orf1 0.39 5.21 0.3 3.74e-7 Large artery stroke; CESC cis rs7208859 0.623 rs216446 chr17:28933718 T/G cg13385521 chr17:29058706 SUZ12P 0.77 5.67 0.33 3.8e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9837602 1.000 rs7610486 chr3:99732564 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.51 0.42 9.05e-13 Breast cancer; CESC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg00310523 chr12:86230176 RASSF9 0.35 5.71 0.33 3.05e-8 Major depressive disorder; CESC cis rs12220238 1.000 rs7096553 chr10:75957835 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.48 0.32 9.99e-8 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2204008 0.569 rs11495449 chr12:37995753 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.87 0.56 5.15e-23 Bladder cancer; CESC cis rs72781680 0.678 rs2551341 chr2:24014778 G/T cg08917208 chr2:24149416 ATAD2B 0.61 5.99 0.35 6.76e-9 Lymphocyte counts; CESC cis rs34779708 0.931 rs34876468 chr10:35424450 G/A cg03585969 chr10:35415529 CREM 0.76 10.09 0.53 1.81e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6496667 0.557 rs2589951 chr15:90958392 T/C cg22089800 chr15:90895588 ZNF774 0.43 5.63 0.33 4.61e-8 Rheumatoid arthritis; CESC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg08470875 chr2:26401718 FAM59B -0.71 -7.68 -0.43 3.13e-13 Gut microbiome composition (summer); CESC cis rs9309473 1.000 rs7585004 chr2:73666645 C/G cg20560298 chr2:73613845 ALMS1 -0.45 -5.91 -0.34 1.06e-8 Metabolite levels; CESC cis rs709400 1.000 rs61995780 chr14:104120612 A/G cg24130564 chr14:104152367 KLC1 -0.42 -5.42 -0.32 1.36e-7 Body mass index; CESC trans rs2727020 0.573 rs7925419 chr11:49231859 C/T cg00717180 chr2:96193071 NA -0.48 -6.82 -0.39 6.01e-11 Coronary artery disease; CESC cis rs7937682 1.000 rs4936661 chr11:111587495 G/A cg09085632 chr11:111637200 PPP2R1B 1.09 15.25 0.68 4.08e-38 Primary sclerosing cholangitis; CESC cis rs7267979 1.000 rs422424 chr20:25445446 G/C cg08601574 chr20:25228251 PYGB 0.37 5.31 0.31 2.31e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs6783573 0.510 rs11718490 chr3:46628763 C/T cg21489266 chr3:46619131 LRRC2;TDGF1 -0.46 -6.5 -0.37 4.02e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg06494592 chr3:125709126 NA -0.52 -5.56 -0.32 6.58e-8 Blood pressure (smoking interaction); CESC cis rs921968 0.565 rs6436070 chr2:219597960 A/G cg02176678 chr2:219576539 TTLL4 -0.45 -8.11 -0.45 1.85e-14 Mean corpuscular hemoglobin concentration; CESC cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg00031303 chr3:195681400 NA 0.46 5.81 0.34 1.74e-8 Pancreatic cancer; CESC cis rs17253792 0.822 rs10083499 chr14:56066590 T/A cg24579896 chr14:56047964 C14orf33;KTN1 0.83 6.18 0.36 2.36e-9 Putamen volume; CESC cis rs6060960 0.502 rs6057968 chr20:30082779 A/T cg13852791 chr20:30311386 BCL2L1 0.5 5.22 0.31 3.66e-7 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21871583 chr3:15374148 SH3BP5 -0.43 -6.25 -0.36 1.6e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9790314 0.502 rs34972965 chr3:160984296 G/A cg03342759 chr3:160939853 NMD3 -0.54 -7.7 -0.43 2.68e-13 Morning vs. evening chronotype; CESC cis rs4132509 1.000 rs6681863 chr1:243982709 C/G cg21452805 chr1:244014465 NA 0.5 6.21 0.36 2.09e-9 RR interval (heart rate); CESC cis rs2014572 0.967 rs8106734 chr19:57763546 C/T cg12963866 chr19:57752005 ZNF805 -0.47 -6.41 -0.37 6.66e-10 Hyperactive-impulsive symptoms; CESC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.57 6.99 0.39 2.29e-11 Height; CESC cis rs950776 0.518 rs12900783 chr15:78815523 G/A cg24631222 chr15:78858424 CHRNA5 -0.4 -5.18 -0.3 4.45e-7 Sudden cardiac arrest; CESC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg09877947 chr5:131593287 PDLIM4 0.48 6.32 0.36 1.11e-9 Acylcarnitine levels; CESC cis rs473651 0.935 rs578510 chr2:239343140 C/T cg21699342 chr2:239360505 ASB1 0.55 9.41 0.5 2.44e-18 Multiple system atrophy; CESC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg24829409 chr8:58192753 C8orf71 -0.74 -8.46 -0.46 1.77e-15 Developmental language disorder (linguistic errors); CESC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.65 0.47 4.88e-16 Menopause (age at onset); CESC cis rs1707322 1.000 rs785507 chr1:46541558 C/T cg05343316 chr1:45956843 TESK2 -0.48 -5.66 -0.33 3.94e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4689388 0.926 rs4688986 chr4:6285797 C/A cg14416269 chr4:6271139 WFS1 0.49 8.17 0.45 1.26e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg08704250 chr15:31115839 NA -0.63 -8.23 -0.45 8.79e-15 Huntington's disease progression; CESC cis rs992157 0.735 rs13392177 chr2:219112956 C/T cg00012203 chr2:219082015 ARPC2 -0.8 -11.49 -0.58 4.77e-25 Colorectal cancer; CESC cis rs3809566 0.526 rs35829897 chr15:63334688 G/C cg05507819 chr15:63340323 TPM1 -0.79 -7.76 -0.43 1.85e-13 Platelet count; CESC cis rs28647808 0.748 rs28502181 chr9:136257792 T/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.75 0.33 2.45e-8 Blood protein levels; CESC cis rs854765 0.583 rs8078105 chr17:17853782 T/C cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg11905131 chr22:24372483 LOC391322 0.7 10.0 0.52 3.49e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7091068 0.518 rs1572772 chr10:95432862 A/G cg20715218 chr10:95462985 C10orf4 -0.47 -5.96 -0.34 8.08e-9 Urinary tract infection frequency; CESC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg19077165 chr18:44547161 KATNAL2 0.65 9.84 0.52 1.13e-19 Personality dimensions; CESC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg05585544 chr11:47624801 NA -0.41 -6.05 -0.35 4.91e-9 Subjective well-being; CESC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.81 0.39 6.64e-11 Bipolar disorder; CESC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg15445000 chr17:37608096 MED1 0.4 6.21 0.36 2.02e-9 Glomerular filtration rate (creatinine); CESC cis rs6582630 0.531 rs3850000 chr12:38483752 T/C cg26384229 chr12:38710491 ALG10B 0.71 10.82 0.55 7.82e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs6977955 0.877 rs9648346 chr7:28160113 C/G cg23620719 chr7:28220237 JAZF1 0.44 5.04 0.3 8.53e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs1577917 1.000 rs12196411 chr6:86779762 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.2 -0.36 2.14e-9 Response to antipsychotic treatment; CESC cis rs3820068 0.581 rs61056912 chr1:15926296 A/G cg17385448 chr1:15911702 AGMAT 0.44 7.16 0.4 7.97e-12 Systolic blood pressure; CESC cis rs1879734 0.731 rs6665257 chr1:54161087 T/C cg23596471 chr1:54105337 GLIS1 0.32 5.45 0.32 1.13e-7 Mitral valve prolapse; CESC cis rs561341 0.783 rs512698 chr17:30292507 G/T cg19193384 chr17:30244184 NA -0.69 -6.46 -0.37 4.99e-10 Hip circumference adjusted for BMI; CESC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg07701084 chr6:150067640 NUP43 -0.47 -6.65 -0.38 1.7e-10 Lung cancer; CESC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.61 0.38 2.1e-10 Prudent dietary pattern; CESC cis rs9815354 0.767 rs73081341 chr3:41900335 A/T cg03022575 chr3:42003672 ULK4 0.56 5.58 0.32 5.87e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.69 0.38 1.35e-10 Bipolar disorder; CESC cis rs3820928 1.000 rs10210763 chr2:227776029 G/T cg11843606 chr2:227700838 RHBDD1 -0.43 -5.74 -0.33 2.55e-8 Pulmonary function; CESC cis rs75477785 0.590 rs10489346 chr1:210235308 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.91 6.32 0.36 1.09e-9 Cleft lip with or without cleft palate; CESC trans rs11264799 0.765 rs7531547 chr1:157623267 G/T cg22691776 chr3:15032403 NR2C2 0.33 6.1 0.35 3.7e-9 IgA nephropathy; CESC cis rs1153858 1.000 rs1288775 chr15:45661678 T/A cg21132104 chr15:45694354 SPATA5L1 0.77 10.24 0.53 5.86e-21 Homoarginine levels; CESC cis rs7577696 0.568 rs177082 chr2:32438350 A/T cg02381751 chr2:32503542 YIPF4 0.46 5.16 0.3 4.77e-7 Inflammatory biomarkers; CESC cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.75 11.04 0.56 1.49e-23 Hip circumference adjusted for BMI; CESC cis rs7914558 0.966 rs56946876 chr10:104653545 T/C cg04362960 chr10:104952993 NT5C2 0.46 5.99 0.35 6.65e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1577917 0.771 rs4383777 chr6:86435960 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.36 5.09 0.3 6.94e-7 Response to antipsychotic treatment; CESC trans rs87938 1.000 rs376362 chr3:41111939 A/T cg27294816 chr19:54372713 MYADM 0.37 6.22 0.36 1.88e-9 Bone mineral density (hip); CESC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg21963583 chr11:68658836 MRPL21 0.38 5.13 0.3 5.62e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7618501 1.000 rs11130221 chr3:49819102 C/G cg24308560 chr3:49941425 MST1R -0.5 -6.8 -0.39 7.06e-11 Intelligence (multi-trait analysis); CESC cis rs752010 0.574 rs10890157 chr1:42117689 C/G cg06885757 chr1:42089581 HIVEP3 0.48 7.61 0.42 4.72e-13 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22483286 chr7:72727303 TRIM50 -0.58 -7.17 -0.4 7.45e-12 Gut microbiome composition (summer); CESC cis rs9487023 1 rs9487023 chr6:109590004 A/G cg21918786 chr6:109611834 NA -0.36 -5.25 -0.31 3.12e-7 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; CESC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg19717773 chr7:2847554 GNA12 -0.47 -6.75 -0.38 9.38e-11 Height; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg26586917 chr4:153899740 FHDC1 -0.41 -6.18 -0.35 2.35e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs901683 1.000 rs36070535 chr10:46022238 T/C cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs826838 1.000 rs11183214 chr12:38692938 C/T cg13010199 chr12:38710504 ALG10B 0.61 8.84 0.48 1.32e-16 Heart rate; CESC cis rs77956314 0.515 rs9804817 chr12:117440220 G/A cg16111737 chr12:117408163 FBXW8 0.45 5.34 0.31 1.98e-7 Subcortical brain region volumes;Hippocampal volume; CESC cis rs66887589 0.967 rs2892869 chr4:120521297 T/C cg09307838 chr4:120376055 NA -0.51 -6.85 -0.39 5.19e-11 Diastolic blood pressure; CESC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg03709012 chr19:19516395 GATAD2A 0.96 14.18 0.66 2.35e-34 Tonsillectomy; CESC cis rs6088580 0.634 rs2225837 chr20:33005634 C/T cg08999081 chr20:33150536 PIGU -0.65 -11.29 -0.57 2.22e-24 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04266929 chr5:54522528 NA 0.52 6.08 0.35 4.08e-9 Gut microbiome composition (summer); CESC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg02951883 chr7:2050386 MAD1L1 -0.58 -7.94 -0.44 5.88e-14 Autism spectrum disorder or schizophrenia; CESC cis rs7084402 0.967 rs1658483 chr10:60288933 C/T cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC trans rs801193 1.000 rs62466794 chr7:66191579 G/A cg26939375 chr7:64535504 NA 0.64 8.67 0.47 4.39e-16 Aortic root size; CESC cis rs870825 0.616 rs55674580 chr4:185626605 C/G cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs1707322 1.000 rs6661500 chr1:46465662 T/C cg06784218 chr1:46089804 CCDC17 0.35 5.95 0.34 8.32e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.35 -0.31 1.89e-7 Total body bone mineral density; CESC cis rs7246657 1.000 rs35398388 chr19:37740358 A/G cg23950597 chr19:37808831 NA -0.61 -6.37 -0.36 8.38e-10 Coronary artery calcification; CESC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg00684032 chr4:1343700 KIAA1530 0.4 5.56 0.32 6.51e-8 Obesity-related traits; CESC cis rs12930096 1.000 rs12444633 chr16:11677857 A/C cg07439791 chr16:11680400 LITAF 0.61 5.59 0.32 5.69e-8 QT interval; CESC cis rs2455799 0.634 rs62243670 chr3:15918990 C/T cg16303742 chr3:15540471 COLQ -0.37 -5.69 -0.33 3.27e-8 Mean platelet volume; CESC cis rs11638352 1.000 rs1820485 chr15:44430332 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -5.29 -0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs2880765 0.743 rs8028240 chr15:86013248 A/G cg10818794 chr15:86012489 AKAP13 -0.34 -5.31 -0.31 2.33e-7 Coronary artery disease; CESC trans rs208520 0.661 rs851466 chr6:66840476 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -13.08 -0.63 1.69e-30 Exhaled nitric oxide output; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18505939 chr19:36427426 LRFN3 -0.44 -6.8 -0.39 7.11e-11 Gambling; CESC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg10691866 chr7:65817282 TPST1 0.33 5.51 0.32 8.51e-8 Aortic root size; CESC cis rs6580649 0.771 rs1034762 chr12:48389643 G/T cg24011408 chr12:48396354 COL2A1 -0.4 -5.17 -0.3 4.54e-7 Lung cancer; CESC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg11366901 chr6:160182831 ACAT2 0.64 8.17 0.45 1.24e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs17376456 0.877 rs28575883 chr5:93346035 T/C cg25358565 chr5:93447407 FAM172A 1.09 10.4 0.54 1.88e-21 Diabetic retinopathy; CESC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg24531977 chr5:56204891 C5orf35 0.69 9.27 0.49 6.83e-18 Type 2 diabetes; CESC cis rs34779708 0.931 rs6481935 chr10:35342959 C/T cg04310649 chr10:35416472 CREM -0.53 -6.42 -0.37 6.1e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.25 -0.36 1.67e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9916302 0.706 rs8182252 chr17:37727950 T/C cg00129232 chr17:37814104 STARD3 0.54 6.1 0.35 3.84e-9 Glomerular filtration rate (creatinine); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08487038 chr9:6413045 UHRF2 0.5 6.35 0.36 9.23e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01831166 chr2:198570100 MARS2 0.56 7.2 0.4 6.17e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg21132104 chr15:45694354 SPATA5L1 0.83 11.19 0.57 4.65e-24 Homoarginine levels; CESC cis rs9300255 0.596 rs10732573 chr12:123743883 G/C cg19016782 chr12:123741754 C12orf65 -0.37 -5.68 -0.33 3.55e-8 Neutrophil percentage of white cells; CESC cis rs11792861 0.816 rs72607157 chr9:111748001 T/G cg13535736 chr9:111863775 C9orf5 -0.47 -6.16 -0.35 2.73e-9 Menarche (age at onset); CESC cis rs6942756 1.000 rs6467233 chr7:128868656 C/T cg02491457 chr7:128862824 NA -0.71 -10.14 -0.53 1.27e-20 White matter hyperintensity burden; CESC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg11764359 chr7:65958608 NA -0.72 -9.69 -0.51 3.32e-19 Aortic root size; CESC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.6 -0.42 4.99e-13 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26582338 chr3:155523741 C3orf33 -0.56 -6.04 -0.35 5.12e-9 Gut microbiome composition (summer); CESC cis rs2346177 0.967 rs4953374 chr2:46654401 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.43 -5.18 -0.3 4.37e-7 HDL cholesterol; CESC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.43 -5.43 -0.32 1.24e-7 Tonsillectomy; CESC cis rs3093024 0.935 rs10946216 chr6:167538897 T/C cg23791538 chr6:167370224 RNASET2 0.42 5.19 0.3 4.27e-7 Rheumatoid arthritis; CESC cis rs9815354 0.812 rs73071242 chr3:41993011 T/C cg03022575 chr3:42003672 ULK4 0.67 5.88 0.34 1.23e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs7309 0.622 rs4664396 chr2:161901650 C/T cg16506815 chr2:162101123 NA -0.38 -5.05 -0.3 8.15e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CESC cis rs1003719 0.762 rs11701556 chr21:38455153 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.67 0.47 4.41e-16 Eye color traits; CESC cis rs2361718 0.500 rs8068856 chr17:78100731 A/G cg21238619 chr17:78079768 GAA -0.36 -5.44 -0.32 1.21e-7 Yeast infection; CESC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg10541313 chr22:46663664 TTC38 0.72 5.84 0.34 1.54e-8 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21317132 chr2:65215566 SLC1A4 -0.55 -6.15 -0.35 2.78e-9 Gut microbiome composition (summer); CESC cis rs9399401 0.614 rs262125 chr6:142838355 A/T cg03128060 chr6:142623767 GPR126 0.33 5.42 0.32 1.35e-7 Chronic obstructive pulmonary disease; CESC cis rs13242816 1.000 rs17138708 chr7:116109062 T/G cg04696780 chr7:116139425 CAV2 -0.63 -5.71 -0.33 2.98e-8 P wave duration; CESC cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg06808227 chr14:105710500 BRF1 -0.57 -6.55 -0.37 3.02e-10 Mean platelet volume;Platelet distribution width; CESC cis rs60843830 1.000 rs3828165 chr2:220889 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.78 9.79 0.52 1.63e-19 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs12824058 0.831 rs4759658 chr12:130815872 C/T cg26677194 chr12:130822605 PIWIL1 0.52 6.82 0.39 6.23e-11 Menopause (age at onset); CESC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg06873352 chr17:61820015 STRADA 0.49 7.24 0.41 4.86e-12 Height; CESC cis rs9916302 0.861 rs11078896 chr17:37415544 C/T cg15445000 chr17:37608096 MED1 0.4 6.54 0.37 3.13e-10 Glomerular filtration rate (creatinine); CESC cis rs11229555 1.000 rs11229545 chr11:58386650 A/G cg15696309 chr11:58395628 NA -0.43 -5.64 -0.33 4.3e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs6963495 0.818 rs17343556 chr7:105151272 C/T cg13798780 chr7:105162888 PUS7 0.76 7.84 0.43 1.12e-13 Bipolar disorder (body mass index interaction); CESC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg19748678 chr4:122722346 EXOSC9 0.78 9.69 0.51 3.39e-19 Type 2 diabetes; CESC cis rs2073300 0.609 rs6137931 chr20:23376875 G/C cg16736954 chr20:23401023 NAPB 0.8 6.25 0.36 1.67e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7584330 0.737 rs60187585 chr2:238365159 C/T cg14458575 chr2:238380390 NA 0.62 8.39 0.46 3.03e-15 Prostate cancer; CESC cis rs9388451 0.626 rs1343115 chr6:126069817 C/G cg05901451 chr6:126070800 HEY2 -0.61 -9.27 -0.49 6.65e-18 Brugada syndrome; CESC cis rs155076 0.711 rs4770131 chr13:21897468 A/G cg06138931 chr13:21896616 NA 0.68 6.52 0.37 3.56e-10 White matter hyperintensity burden; CESC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg11764359 chr7:65958608 NA -0.78 -11.58 -0.58 2.21e-25 Aortic root size; CESC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg18016565 chr1:150552671 MCL1 -0.35 -5.89 -0.34 1.15e-8 Tonsillectomy; CESC cis rs13191362 1.000 rs35583420 chr6:163214327 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.97 9.11 0.49 2.06e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs561341 1.000 rs497479 chr17:30328605 C/T cg20587970 chr11:113659929 NA -1.39 -18.35 -0.75 4.13e-49 Hip circumference adjusted for BMI; CESC cis rs9400467 0.506 rs12199233 chr6:111592317 G/A cg15721981 chr6:111408429 SLC16A10 0.53 5.11 0.3 6.28e-7 Blood metabolite levels;Amino acid levels; CESC cis rs7659604 0.702 rs58649165 chr4:122693752 C/A cg06713675 chr4:122721982 EXOSC9 -0.39 -5.64 -0.33 4.43e-8 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08555013 chr4:83932063 LIN54 0.6 6.46 0.37 4.92e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg27170947 chr2:26402098 FAM59B 0.61 7.09 0.4 1.19e-11 Gut microbiome composition (summer); CESC cis rs910316 0.737 rs175080 chr14:75513828 G/A cg11812906 chr14:75593930 NEK9 -0.82 -13.36 -0.63 1.72e-31 Height; CESC cis rs644799 0.710 rs522536 chr11:95528714 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.77 10.82 0.55 8.02e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6121246 0.559 rs6060950 chr20:30378031 T/C cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs78456975 0.506 rs10167704 chr2:1571037 G/C cg12573674 chr2:1569213 NA -0.47 -5.35 -0.31 1.93e-7 Placebo response in major depressive disorder (% change in symptom score); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13503583 chr14:105282271 NA -0.51 -6.6 -0.38 2.28e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7243790 0.837 rs1992129 chr18:51946093 G/T cg04730925 chr18:51795821 POLI -0.43 -5.76 -0.33 2.33e-8 Diastolic blood pressure; CESC trans rs7618501 0.699 rs2681781 chr3:49898273 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.49 6.8 0.39 6.79e-11 Intelligence (multi-trait analysis); CESC cis rs1348850 0.526 rs6723063 chr2:178491398 C/T cg22681709 chr2:178499509 PDE11A -0.52 -5.36 -0.31 1.82e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11388866 chr21:40752116 WRB 0.63 7.13 0.4 9.61e-12 Gut microbiome composition (summer); CESC cis rs6912958 0.781 rs2300906 chr6:88207155 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -5.93 -0.34 9.18e-9 Monocyte percentage of white cells; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03044510 chr21:27107978 ATP5J;GABPA 0.47 6.26 0.36 1.53e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs151227923 1 rs151227923 chr7:155106564 C/T cg14927855 chr7:155151427 NA 0.49 8.0 0.44 3.96e-14 Stem cell growth factor beta levels; CESC cis rs4727963 0.765 rs6971635 chr7:122704188 C/T cg03640110 chr7:122635026 TAS2R16 0.41 6.49 0.37 4.11e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs11690935 0.686 rs10165126 chr2:172820315 C/T cg13550731 chr2:172543902 DYNC1I2 -0.67 -9.93 -0.52 5.85e-20 Schizophrenia; CESC cis rs3820068 0.581 rs72645871 chr1:15926142 G/A cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs1707322 1.000 rs34446427 chr1:46417655 A/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs34638657 0.673 rs62045961 chr16:82199723 A/G cg09439754 chr16:82129088 HSD17B2 -0.37 -6.42 -0.37 6.31e-10 Lung adenocarcinoma; CESC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg11764359 chr7:65958608 NA -0.79 -11.67 -0.58 1.16e-25 Aortic root size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04653284 chr16:28875071 SH2B1 -0.51 -6.16 -0.35 2.69e-9 Ulcerative colitis; CESC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg03934478 chr11:495069 RNH1 0.52 5.05 0.3 8.42e-7 Body mass index; CESC cis rs2180341 0.804 rs6902233 chr6:127555963 A/G cg24812749 chr6:127587940 RNF146 0.95 11.43 0.57 7.26e-25 Breast cancer; CESC cis rs6540556 0.723 rs10863785 chr1:209908876 C/T cg23920097 chr1:209922102 NA 0.39 5.07 0.3 7.64e-7 Red blood cell count; CESC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg11247378 chr22:39784982 NA -0.63 -9.31 -0.5 5.01e-18 Intelligence (multi-trait analysis); CESC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs2204008 0.748 rs11514352 chr12:38246954 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.11 0.53 1.52e-20 Bladder cancer; CESC cis rs7264396 0.580 rs6119655 chr20:34412049 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -10.45 -0.54 1.21e-21 Total cholesterol levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11150667 chr3:195595368 TNK2 0.48 6.31 0.36 1.14e-9 Fibrinogen levels; CESC cis rs6775745 0.654 rs1976992 chr3:131779012 G/A cg12213930 chr3:131751605 CPNE4 0.48 5.5 0.32 8.82e-8 Neutrophil count; CESC cis rs503341 0.756 rs11231591 chr11:63587986 G/T cg04362095 chr11:63592001 C11orf84 -0.56 -7.98 -0.44 4.36e-14 Pulse pressure; CESC cis rs6433857 0.505 rs7561255 chr2:181369216 A/G cg23363182 chr2:181467187 NA -0.42 -5.96 -0.34 7.9e-9 Body mass index; CESC cis rs3733585 0.699 rs6449171 chr4:9965998 C/T cg11266682 chr4:10021025 SLC2A9 0.58 10.41 0.54 1.67e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2274273 0.588 rs11158037 chr14:55832152 C/A cg04306507 chr14:55594613 LGALS3 0.29 5.17 0.3 4.65e-7 Protein biomarker; CESC cis rs73206853 0.686 rs73206895 chr12:110879968 A/G cg12870014 chr12:110450643 ANKRD13A 0.63 5.18 0.3 4.34e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs11098499 0.866 rs13105020 chr4:120285688 G/T cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs4642101 0.662 rs57411588 chr3:12820384 C/G cg24848339 chr3:12840334 CAND2 0.38 6.02 0.35 5.8e-9 QRS complex (12-leadsum); CESC cis rs1348850 0.526 rs6723014 chr2:178410586 G/A cg22681709 chr2:178499509 PDE11A -0.5 -5.3 -0.31 2.44e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10791097 0.694 rs7106995 chr11:130758152 G/T cg12179176 chr11:130786555 SNX19 0.65 10.09 0.53 1.76e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9611519 0.565 rs8135524 chr22:41436442 T/C cg03806693 chr22:41940476 POLR3H -0.51 -6.0 -0.35 6.59e-9 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27007625 chr2:240896183 NA -0.6 -6.48 -0.37 4.55e-10 Gut microbiome composition (summer); CESC trans rs9945268 0.964 rs7227150 chr18:59331815 A/G cg24536146 chr1:207997166 NA -0.4 -6.31 -0.36 1.19e-9 Glomerular filtration rate (creatinine); CESC cis rs7084402 0.764 rs2033149 chr10:60264741 A/T cg07615347 chr10:60278583 BICC1 0.59 9.22 0.49 9.73e-18 Refractive error; CESC cis rs3126085 0.935 rs4361987 chr1:152229701 A/G cg03465714 chr1:152285911 FLG -0.46 -5.7 -0.33 3.14e-8 Atopic dermatitis; CESC cis rs6693567 0.545 rs1566225 chr1:150415990 G/C cg09579323 chr1:150459698 TARS2 0.48 6.0 0.35 6.34e-9 Migraine; CESC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg24060327 chr5:131705240 SLC22A5 -0.77 -10.78 -0.55 1.05e-22 Acylcarnitine levels; CESC cis rs4909189 1.000 rs4909189 chr7:158136986 A/T cg27057461 chr7:158136379 PTPRN2 0.38 5.25 0.31 3.15e-7 Response to amphetamines; CESC cis rs919433 0.889 rs788001 chr2:198213720 C/T cg20885578 chr2:198174922 NA 0.4 5.42 0.32 1.31e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs5753618 0.583 rs5753601 chr22:31798259 G/T cg13145458 chr22:31556086 RNF185 -0.5 -5.96 -0.34 7.96e-9 Colorectal cancer; CESC cis rs6732160 0.656 rs2043093 chr2:73407342 G/C cg01422370 chr2:73384389 NA 0.45 7.6 0.42 5.07e-13 Intelligence (multi-trait analysis); CESC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg06074448 chr4:187884817 NA -0.38 -5.52 -0.32 8.08e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg07493874 chr5:1342172 CLPTM1L 0.37 6.83 0.39 5.81e-11 Lung cancer; CESC cis rs4664308 1.000 rs10929966 chr2:160908341 C/T cg03641300 chr2:160917029 PLA2R1 -0.67 -10.16 -0.53 1.08e-20 Idiopathic membranous nephropathy; CESC cis rs3793683 0.545 rs12784407 chr10:134589631 A/G cg27286337 chr10:134555280 INPP5A 0.7 8.03 0.44 3.21e-14 Migraine; CESC cis rs6032067 0.673 rs4522674 chr20:43893276 T/C cg10761708 chr20:43804764 PI3 0.41 5.14 0.3 5.43e-7 Blood protein levels; CESC cis rs938554 0.692 rs13125209 chr4:9982044 A/C cg11266682 chr4:10021025 SLC2A9 0.36 5.03 0.3 8.88e-7 Blood metabolite levels; CESC cis rs4851551 0.543 rs62156407 chr2:102824622 C/T cg09363443 chr2:102758946 NA 0.65 5.26 0.31 2.94e-7 Blood protein levels; CESC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg05890377 chr2:74357713 NA 0.8 10.16 0.53 1.06e-20 Gestational age at birth (maternal effect); CESC cis rs7914558 0.752 rs7896519 chr10:104866863 C/T cg04362960 chr10:104952993 NT5C2 0.46 5.81 0.34 1.74e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs546131 0.928 rs572690 chr11:34833614 A/G cg06937548 chr11:34938143 PDHX;APIP 0.52 6.59 0.38 2.38e-10 Lung disease severity in cystic fibrosis; CESC cis rs9916302 0.861 rs11658219 chr17:37709782 G/A cg20243544 chr17:37824526 PNMT 0.48 5.91 0.34 1.07e-8 Glomerular filtration rate (creatinine); CESC cis rs11969893 0.649 rs9485415 chr6:101279459 C/T cg12253828 chr6:101329408 ASCC3 0.94 8.23 0.45 8.37e-15 Economic and political preferences (immigration/crime); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15424593 chr16:34777963 NA -0.5 -6.38 -0.36 7.96e-10 Gut microbiome composition (summer); CESC cis rs9549367 0.713 rs11620600 chr13:113829090 G/A cg18105134 chr13:113819100 PROZ -0.71 -8.53 -0.46 1.13e-15 Platelet distribution width; CESC cis rs7772486 0.686 rs857879 chr6:145974043 C/A cg05347473 chr6:146136440 FBXO30 -0.53 -6.97 -0.39 2.51e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4930103 0.935 rs2071095 chr11:2020627 C/A cg23202291 chr11:1979235 NA 0.35 5.04 0.3 8.79e-7 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs3733585 0.673 rs10000983 chr4:9951606 T/C cg00071950 chr4:10020882 SLC2A9 -0.7 -11.53 -0.58 3.42e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3888647 0.561 rs4758617 chr11:2995185 T/A cg25174290 chr11:3078921 CARS 0.52 7.06 0.4 1.48e-11 Type 2 diabetes; CESC cis rs9430161 0.579 rs7542158 chr1:11040193 G/A cg02454025 chr1:11042201 C1orf127 0.87 13.72 0.64 9.82e-33 Ewing sarcoma; CESC cis rs6732160 0.809 rs13387480 chr2:73371007 C/T cg01422370 chr2:73384389 NA 0.42 7.2 0.4 6.17e-12 Intelligence (multi-trait analysis); CESC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg21433313 chr16:3507492 NAT15 0.51 8.54 0.46 1.1e-15 Tuberculosis; CESC cis rs7267979 0.932 rs367666 chr20:25449818 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.83 15.78 0.7 5.17e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs6088580 0.609 rs2378205 chr20:33110803 C/G cg06115741 chr20:33292138 TP53INP2 0.45 5.8 0.34 1.88e-8 Glomerular filtration rate (creatinine); CESC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg21724239 chr8:58056113 NA 0.57 5.76 0.33 2.29e-8 Developmental language disorder (linguistic errors); CESC cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg15017067 chr4:17643749 FAM184B 0.37 5.21 0.3 3.74e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs324780 0.506 rs370604 chr12:83926427 C/T cg22140261 chr22:42466895 NAGA -0.48 -6.12 -0.35 3.34e-9 Vertical cup-disc ratio; CESC cis rs12079745 1.000 rs12076510 chr1:169162084 A/G cg09363564 chr1:169337483 NME7;BLZF1 -0.71 -5.51 -0.32 8.29e-8 QT interval; CESC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg04369109 chr6:150039330 LATS1 -0.42 -5.83 -0.34 1.61e-8 Lung cancer; CESC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs2073300 1.000 rs6137961 chr20:23443102 G/T cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.51e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4660306 1.000 rs4660870 chr1:45995231 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.51 -6.54 -0.37 3.07e-10 Homocysteine levels; CESC cis rs6963495 0.872 rs1569134 chr7:105158228 T/C cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs34330 0.562 rs11055024 chr12:12858969 A/G cg04607235 chr12:12878440 APOLD1 -0.84 -9.1 -0.49 2.3e-17 Systemic lupus erythematosus; CESC cis rs116095464 0.558 rs7715108 chr5:264661 A/G cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.51e-10 Breast cancer; CESC cis rs4566357 1.000 rs2177597 chr2:227922546 C/T cg11843606 chr2:227700838 RHBDD1 -0.42 -5.28 -0.31 2.71e-7 Coronary artery disease; CESC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg03352830 chr11:487213 PTDSS2 0.75 7.18 0.4 7.06e-12 Body mass index; CESC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg24308560 chr3:49941425 MST1R 0.63 9.28 0.5 6.27e-18 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg05368731 chr17:41323189 NBR1 0.75 10.35 0.54 2.72e-21 Menopause (age at onset); CESC cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg17366294 chr4:99064904 C4orf37 0.51 6.62 0.38 1.93e-10 Colonoscopy-negative controls vs population controls; CESC cis rs9486715 0.758 rs2971610 chr6:97027380 C/T cg18709589 chr6:96969512 KIAA0776 -0.45 -6.39 -0.37 7.52e-10 Headache; CESC cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg24818145 chr4:99064322 C4orf37 -0.39 -5.18 -0.3 4.46e-7 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17377491 chr11:112096999 PTS -0.42 -6.09 -0.35 3.99e-9 Gambling; CESC cis rs17376456 0.569 rs7713956 chr5:93133185 T/C cg25358565 chr5:93447407 FAM172A -0.71 -7.57 -0.42 6.21e-13 Diabetic retinopathy; CESC cis rs17666538 0.585 rs6559064 chr8:623061 G/A cg23958373 chr8:599963 NA 0.82 5.92 0.34 1.02e-8 IgG glycosylation; CESC cis rs7107174 0.579 rs10793299 chr11:78018954 T/A cg02023728 chr11:77925099 USP35 0.48 6.27 0.36 1.46e-9 Testicular germ cell tumor; CESC cis rs709400 0.930 rs10134399 chr14:104083457 G/A cg12935359 chr14:103987150 CKB -0.44 -5.61 -0.33 5.14e-8 Body mass index; CESC cis rs3892630 0.588 rs12610342 chr19:33250690 C/T cg13157960 chr19:33183277 NUDT19 0.54 5.31 0.31 2.32e-7 Red blood cell traits; CESC cis rs7178909 0.872 rs28468074 chr15:90435600 C/T cg19708238 chr15:90437601 AP3S2 0.43 6.23 0.36 1.86e-9 Common traits (Other); CESC cis rs2832191 0.692 rs8134627 chr21:30349069 C/T cg08807101 chr21:30365312 RNF160 -0.91 -14.05 -0.65 6.69e-34 Dental caries; CESC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg03605463 chr16:89740564 NA 0.66 7.83 0.43 1.14e-13 Vitiligo; CESC cis rs2777491 0.915 rs7178777 chr15:41634588 C/A cg02330683 chr15:41787940 ITPKA 0.44 6.51 0.37 3.74e-10 Ulcerative colitis; CESC cis rs8062405 0.824 rs4788084 chr16:28539848 C/T cg07382826 chr16:28625726 SULT1A1 0.31 5.05 0.3 8.32e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs3820068 0.603 rs72645887 chr1:15929905 G/C cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg08027265 chr7:2291960 NA -0.36 -5.48 -0.32 1e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.87 9.17 0.49 1.38e-17 Platelet count; CESC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1030877 0.515 rs2576736 chr2:105890971 C/T cg02079111 chr2:105885981 TGFBRAP1 0.5 6.52 0.37 3.61e-10 Obesity-related traits; CESC cis rs6964587 0.839 rs17731846 chr7:91440342 A/G cg17063962 chr7:91808500 NA 0.48 6.19 0.36 2.22e-9 Breast cancer; CESC cis rs7714584 1.000 rs7736873 chr5:150258482 T/C cg22134413 chr5:150180641 NA 0.48 5.35 0.31 1.86e-7 Crohn's disease; CESC cis rs9473147 0.543 rs1004173 chr6:47445017 C/T cg20196966 chr6:47445060 CD2AP 0.39 5.03 0.3 9.22e-7 Platelet distribution width;Mean platelet volume; CESC cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg15017067 chr4:17643749 FAM184B 0.4 5.77 0.33 2.23e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs80282103 0.618 rs11816485 chr10:1147974 T/C cg08668510 chr10:1095578 IDI1 0.76 6.28 0.36 1.36e-9 Glomerular filtration rate (creatinine); CESC cis rs9640161 0.789 rs13223702 chr7:150058968 G/A cg17279839 chr7:150038598 RARRES2 0.48 5.75 0.33 2.51e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg18876405 chr7:65276391 NA -0.57 -7.75 -0.43 1.97e-13 Aortic root size; CESC cis rs7296418 0.961 rs1790121 chr12:123604492 G/A cg00376283 chr12:123451042 ABCB9 0.72 10.31 0.54 3.58e-21 Platelet count; CESC cis rs208520 0.690 rs176289 chr6:66766522 C/T cg07460842 chr6:66804631 NA -0.96 -13.07 -0.63 1.89e-30 Exhaled nitric oxide output; CESC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg20151795 chr6:28129481 ZNF389 0.44 5.74 0.33 2.6e-8 Depression; CESC cis rs7647973 0.600 rs13064780 chr3:49274826 T/G cg06212747 chr3:49208901 KLHDC8B 0.7 10.45 0.54 1.24e-21 Menarche (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14839905 chr11:68183723 LRP5 0.47 6.18 0.35 2.35e-9 Fibrinogen levels; CESC cis rs826838 0.900 rs1403523 chr12:39130570 T/A cg13010199 chr12:38710504 ALG10B -0.45 -6.27 -0.36 1.48e-9 Heart rate; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg04238871 chr10:126431886 FAM53B 0.44 6.06 0.35 4.63e-9 Post-traumatic stress disorder; CESC cis rs3820928 0.839 rs10197773 chr2:227824835 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -5.67 -0.33 3.79e-8 Pulmonary function; CESC cis rs9640161 0.789 rs6964110 chr7:150041836 A/C cg27494647 chr7:150038898 RARRES2 0.43 5.64 0.33 4.26e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg07677032 chr17:61819896 STRADA 0.41 5.37 0.31 1.75e-7 Prudent dietary pattern; CESC cis rs17433780 0.897 rs17434151 chr1:89500526 G/T cg09516651 chr1:89888402 LOC400759 0.68 9.56 0.51 8.55e-19 Carotid intima media thickness; CESC cis rs829661 0.947 rs829665 chr2:30724701 T/A cg17749961 chr2:30669863 LCLAT1 1.05 9.57 0.51 7.98e-19 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs35110281 0.805 rs2838330 chr21:45023876 T/A cg21573476 chr21:45109991 RRP1B -0.46 -6.34 -0.36 9.62e-10 Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09709060 chr11:95522957 CEP57;FAM76B 0.58 7.64 0.42 3.93e-13 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs2030746 1.000 rs2030746 chr2:121309488 C/T cg15455772 chr8:33269701 FUT10 0.43 6.03 0.35 5.45e-9 LDL cholesterol;Total cholesterol levels;LDL cholesterol levels; CESC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg10053473 chr17:62856997 LRRC37A3 -0.72 -7.62 -0.42 4.44e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2625529 0.617 rs3784313 chr15:72187519 G/T cg16672083 chr15:72433130 SENP8 0.45 6.77 0.38 8.17e-11 Red blood cell count; CESC trans rs2120243 0.647 rs7632702 chr3:157145903 C/T cg23109721 chr2:106886537 NA -0.39 -6.13 -0.35 3.14e-9 Hepatocellular carcinoma in hepatitis B infection; CESC cis rs1832871 0.672 rs9457345 chr6:158743098 A/G cg07165851 chr6:158734300 TULP4 0.59 6.41 0.37 6.63e-10 Height; CESC cis rs722599 0.748 rs61978948 chr14:75363369 G/A cg11812906 chr14:75593930 NEK9 -0.47 -5.61 -0.33 5.15e-8 IgG glycosylation; CESC cis rs1559088 0.847 rs3786933 chr19:33602881 C/T cg27124370 chr19:33622961 WDR88 0.45 5.86 0.34 1.34e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2932538 0.883 rs6701351 chr1:113139196 G/A cg22162597 chr1:113214053 CAPZA1 0.49 6.56 0.37 2.84e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs116095464 0.558 rs10079760 chr5:230778 A/G cg10591111 chr5:226296 SDHA -0.52 -6.53 -0.37 3.4e-10 Breast cancer; CESC cis rs6500602 0.727 rs4786510 chr16:4571247 A/G cg08645402 chr16:4508243 NA 0.54 8.71 0.47 3.29e-16 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25386411 chr1:232766478 NA 0.55 6.06 0.35 4.55e-9 Gut microbiome composition (summer); CESC cis rs7520050 0.807 rs4660312 chr1:46110572 A/G cg03146154 chr1:46216737 IPP 0.52 6.88 0.39 4.28e-11 Red blood cell count;Reticulocyte count; CESC cis rs3768617 0.510 rs7525917 chr1:183065406 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 13.25 0.63 4.47e-31 Fuchs's corneal dystrophy; CESC cis rs820218 0.892 rs820215 chr17:73693810 A/G cg01592526 chr17:73663357 RECQL5;SAP30BP -0.48 -6.54 -0.37 3.09e-10 Rotator cuff tears; CESC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg07936489 chr17:37558343 FBXL20 -0.79 -11.12 -0.56 7.81e-24 Glomerular filtration rate (creatinine); CESC cis rs10927875 0.518 rs1763597 chr1:16343297 C/T cg22431228 chr1:16359049 CLCNKA -0.52 -9.9 -0.52 7.22e-20 Dilated cardiomyopathy; CESC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.84 0.34 1.49e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07353731 chr12:123341735 HIP1R -0.65 -7.4 -0.41 1.86e-12 Gut microbiome composition (summer); CESC cis rs7223966 1.000 rs8077265 chr17:61732727 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.55 0.42 7e-13 Hip circumference adjusted for BMI;Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03028685 chr10:99078963 FRAT1 0.58 6.82 0.39 6.22e-11 Gut microbiome composition (summer); CESC cis rs4481887 1.000 rs7527822 chr1:248467301 A/G cg00666640 chr1:248458726 OR2T12 0.38 6.73 0.38 1.03e-10 Common traits (Other); CESC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.53 7.0 0.4 2.08e-11 Tuberculosis; CESC cis rs8114671 0.662 rs6088664 chr20:33551100 G/A cg07148914 chr20:33460835 GGT7 0.44 5.66 0.33 3.83e-8 Height; CESC cis rs2243480 0.901 rs73142137 chr7:65343442 A/T cg12463550 chr7:65579703 CRCP 0.69 5.53 0.32 7.85e-8 Diabetic kidney disease; CESC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg11764359 chr7:65958608 NA 0.79 11.32 0.57 1.67e-24 Aortic root size; CESC cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg03467027 chr4:99064603 C4orf37 0.43 5.48 0.32 1.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2288912 0.807 rs3760626 chr19:45457105 A/G cg09555818 chr19:45449301 APOC2 0.41 6.54 0.37 3.08e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2354432 1.000 rs7514864 chr1:146690102 T/C cg25205988 chr1:146714368 CHD1L 1.08 11.4 0.57 8.97e-25 Mitochondrial DNA levels; CESC cis rs9790314 0.580 rs10936227 chr3:161043869 A/C cg03342759 chr3:160939853 NMD3 -0.44 -6.28 -0.36 1.41e-9 Morning vs. evening chronotype; CESC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg04944784 chr2:26401820 FAM59B -0.96 -10.5 -0.54 8.76e-22 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23477849 chr19:5698492 LONP1 -0.57 -6.45 -0.37 5.17e-10 Gut microbiome composition (summer); CESC cis rs6866344 0.697 rs11749438 chr5:178131245 C/T cg10224037 chr5:178157518 ZNF354A 0.67 7.44 0.42 1.39e-12 Neutrophil percentage of white cells; CESC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg27094323 chr7:1216898 NA -0.37 -5.18 -0.3 4.4e-7 Longevity;Endometriosis; CESC cis rs2425143 1.000 rs2378409 chr20:34392464 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 7.72e-12 Blood protein levels; CESC cis rs9487051 0.714 rs1546722 chr6:109625797 A/G cg01475377 chr6:109611718 NA -0.43 -6.66 -0.38 1.6e-10 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06551493 chr7:77166702 PTPN12 0.53 6.39 0.37 7.53e-10 Gut microbiome composition (summer); CESC cis rs2014572 1.000 rs2014572 chr19:57760018 G/A cg12963866 chr19:57752005 ZNF805 -0.47 -6.28 -0.36 1.38e-9 Hyperactive-impulsive symptoms; CESC trans rs941207 0.542 rs6581106 chr12:57190543 G/A cg26462586 chr2:11164677 NA 0.38 6.1 0.35 3.66e-9 Platelet count; CESC cis rs3204270 0.500 rs62077175 chr17:79649568 G/T cg26965718 chr17:79658957 HGS -0.74 -5.65 -0.33 4.16e-8 Dental caries; CESC cis rs950776 0.616 rs12901300 chr15:78892952 G/A cg06917634 chr15:78832804 PSMA4 0.56 7.26 0.41 4.24e-12 Sudden cardiac arrest; CESC cis rs11098499 0.604 rs17051352 chr4:120581427 G/A cg09307838 chr4:120376055 NA 0.75 9.29 0.5 6.05e-18 Corneal astigmatism; CESC cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg12826209 chr6:26865740 GUSBL1 0.73 8.13 0.45 1.7e-14 Intelligence (multi-trait analysis); CESC cis rs6496667 0.510 rs7495784 chr15:91068882 T/C cg10434728 chr15:90938212 IQGAP1 -0.33 -5.27 -0.31 2.77e-7 Rheumatoid arthritis; CESC cis rs78456975 1.000 rs13414537 chr2:1556330 C/T cg26248373 chr2:1572462 NA -0.58 -5.22 -0.31 3.68e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4253772 0.550 rs715515 chr22:46720921 G/A cg24881330 chr22:46731750 TRMU 0.78 5.94 0.34 9.12e-9 LDL cholesterol;Cholesterol, total; CESC cis rs7927592 0.513 rs653056 chr11:68203625 T/C cg01657329 chr11:68192670 LRP5 -0.55 -7.23 -0.41 5.07e-12 Total body bone mineral density; CESC cis rs3126085 0.935 rs1496045 chr1:152184704 C/T cg26876637 chr1:152193138 HRNR 0.48 5.44 0.32 1.21e-7 Atopic dermatitis; CESC cis rs27434 0.529 rs34757 chr5:96152588 T/C cg16492584 chr5:96139282 ERAP1 -0.37 -5.35 -0.31 1.89e-7 Ankylosing spondylitis; CESC cis rs561341 1.000 rs72821952 chr17:30248133 T/A cg00745463 chr17:30367425 LRRC37B -0.81 -7.22 -0.41 5.54e-12 Hip circumference adjusted for BMI; CESC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg12463550 chr7:65579703 CRCP -0.57 -7.38 -0.41 2.02e-12 Aortic root size; CESC cis rs7116495 0.609 rs1548348 chr11:71750917 A/G cg26138937 chr11:71823887 C11orf51 -1.24 -7.4 -0.41 1.82e-12 Severe influenza A (H1N1) infection; CESC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg19774624 chr17:42201019 HDAC5 -0.89 -14.35 -0.66 6.3e-35 Total body bone mineral density; CESC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs72945132 0.882 rs55758686 chr11:70172204 C/T cg14191688 chr11:70257035 CTTN 0.43 5.46 0.32 1.11e-7 Coronary artery disease; CESC cis rs8072100 0.790 rs34200664 chr17:45744652 C/T cg08085267 chr17:45401833 C17orf57 0.44 5.54 0.32 7.36e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs8072100 0.576 rs7216112 chr17:45406345 C/T cg08085267 chr17:45401833 C17orf57 0.65 8.29 0.45 5.66e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs10911232 0.507 rs10752890 chr1:183021910 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.43 0.64 1.05e-31 Hypertriglyceridemia; CESC cis rs921968 0.643 rs2278530 chr2:219501133 G/A cg02176678 chr2:219576539 TTLL4 0.46 8.34 0.46 4.1e-15 Mean corpuscular hemoglobin concentration; CESC cis rs2880765 0.835 rs11633604 chr15:86031579 T/G cg19183879 chr15:85880815 NA -0.25 -5.26 -0.31 3.03e-7 Coronary artery disease; CESC cis rs6426558 0.537 rs6699828 chr1:227274591 T/C cg10327440 chr1:227177885 CDC42BPA 0.47 5.75 0.33 2.42e-8 Neutrophil percentage of white cells; CESC cis rs8078723 0.690 rs3785549 chr17:38149724 T/C cg17467752 chr17:38218738 THRA -0.56 -8.52 -0.46 1.22e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg13175981 chr1:150552382 MCL1 0.62 9.23 0.49 9.09e-18 Tonsillectomy; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09123307 chr7:6746650 ZNF12 -0.5 -6.44 -0.37 5.67e-10 Ulcerative colitis; CESC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs7674212 0.539 rs6815783 chr4:104122146 A/C cg16532752 chr4:104119610 CENPE -0.4 -5.48 -0.32 1.01e-7 Type 2 diabetes; CESC cis rs28489187 0.597 rs506082 chr1:85899215 A/C cg16011679 chr1:85725395 C1orf52 -0.44 -5.28 -0.31 2.7e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs3106136 0.934 rs4693004 chr4:95168456 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.8 -0.39 6.94e-11 Capecitabine sensitivity; CESC cis rs41307935 0.722 rs12724052 chr1:27234682 G/A cg12203394 chr1:27248618 NUDC 0.65 5.51 0.32 8.6e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1707322 0.928 rs7527244 chr1:46368772 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.52 0.32 8.1e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6537837 0.838 rs12046010 chr1:110104189 A/C cg05049280 chr1:110155535 GNAT2 0.41 5.74 0.33 2.62e-8 Major depressive disorder; CESC cis rs9831754 0.756 rs6548554 chr3:78423185 C/T cg06138941 chr3:78371609 NA -0.52 -6.53 -0.37 3.29e-10 Calcium levels; CESC trans rs3780486 1.000 rs3780486 chr9:33139453 C/T cg20290983 chr6:43655470 MRPS18A 0.85 12.23 0.6 1.45e-27 IgG glycosylation; CESC cis rs4423214 0.559 rs10898203 chr11:71203436 C/T cg24826892 chr11:71159390 DHCR7 -0.54 -5.12 -0.3 5.94e-7 Vitamin D levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27220681 chr17:685915 RNMTL1;GLOD4 -0.49 -6.5 -0.37 3.99e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg14829155 chr15:31115871 NA -0.7 -9.48 -0.5 1.52e-18 Huntington's disease progression; CESC cis rs6912958 0.781 rs9444504 chr6:88181046 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.45 -6.14 -0.35 3.01e-9 Monocyte percentage of white cells; CESC cis rs11098499 0.863 rs6858592 chr4:120458692 G/A cg24375607 chr4:120327624 NA 0.42 5.05 0.3 8.24e-7 Corneal astigmatism; CESC cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg00033643 chr7:134001901 SLC35B4 0.43 5.56 0.32 6.56e-8 Mean platelet volume; CESC trans rs61931739 0.500 rs11053261 chr12:34530810 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.97 -11.12 -0.56 7.79e-24 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs7736600 chr5:231337 A/C cg10591111 chr5:226296 SDHA -0.51 -6.18 -0.35 2.44e-9 Breast cancer; CESC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.62 0.64 2.2e-32 Prudent dietary pattern; CESC cis rs748404 0.588 rs2255410 chr15:43831097 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.54 6.95 0.39 2.87e-11 Lung cancer; CESC cis rs1215050 0.782 rs6853916 chr4:98653387 C/T cg05340658 chr4:99064831 C4orf37 -0.47 -6.04 -0.35 5.08e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7605827 0.930 rs11889160 chr2:15605509 C/T cg19274914 chr2:15703543 NA 0.35 6.33 0.36 1.05e-9 Educational attainment (years of education); CESC cis rs1707322 1.000 rs10890355 chr1:46317348 G/A cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22122542 chr4:113486179 C4orf21 0.41 6.3 0.36 1.24e-9 Gambling; CESC cis rs7481584 0.624 rs449164 chr11:3053454 C/T cg25174290 chr11:3078921 CARS -0.43 -6.04 -0.35 5.18e-9 Calcium levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00254426 chr21:30374028 NA 0.4 6.06 0.35 4.67e-9 Gut microbiota (bacterial taxa); CESC cis rs9486719 1.000 rs2142652 chr6:96868504 A/C cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs7819412 0.668 rs4841507 chr8:11046394 C/G cg21775007 chr8:11205619 TDH -0.38 -5.62 -0.33 4.96e-8 Triglycerides; CESC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg14829155 chr15:31115871 NA 0.76 10.65 0.55 2.87e-22 Huntington's disease progression; CESC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg11663144 chr21:46675770 NA -0.63 -9.74 -0.51 2.28e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs61990749 0.500 rs8011337 chr14:78272626 T/G cg23188588 chr14:78226832 SNW1;C14orf178 0.5 5.15 0.3 5.07e-7 Fibroblast growth factor basic levels; CESC cis rs910316 1.000 rs175442 chr14:75603564 T/C cg11812906 chr14:75593930 NEK9 -0.87 -14.98 -0.68 3.74e-37 Height; CESC cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg10523679 chr1:76189770 ACADM 0.74 8.74 0.47 2.79e-16 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9318086 0.712 rs9510916 chr13:24442789 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.42 5.82 0.34 1.69e-8 Myopia (pathological); CESC cis rs2688608 0.620 rs7076525 chr10:75512797 C/T cg23231163 chr10:75533350 FUT11 -0.37 -5.65 -0.33 4.06e-8 Inflammatory bowel disease; CESC trans rs3942852 0.955 rs6485809 chr11:48112468 C/T cg15704280 chr7:45808275 SEPT13 -0.68 -7.52 -0.42 8.24e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs7772486 0.875 rs2777483 chr6:146329235 A/G cg23711669 chr6:146136114 FBXO30 0.81 11.45 0.58 6.31e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs8060686 0.920 rs2271293 chr16:67902070 A/G cg26727032 chr16:67993705 SLC12A4 0.55 5.92 0.34 9.84e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg23300289 chr9:132146083 NA 0.48 6.4 0.37 6.92e-10 Systemic lupus erythematosus; CESC cis rs2108622 0.647 rs111427692 chr19:15977479 A/T cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs4666360 1.000 rs10196396 chr2:20337035 C/T cg23291376 chr2:20336282 NA 0.37 6.34 0.36 9.68e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel); CESC cis rs4555082 0.874 rs28625632 chr14:105748849 G/T cg13114125 chr14:105738426 BRF1 -0.86 -10.36 -0.54 2.37e-21 Mean platelet volume;Platelet distribution width; CESC cis rs854765 0.663 rs4925120 chr17:17754633 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.48 -6.85 -0.39 5.21e-11 Total body bone mineral density; CESC cis rs1185460 1.000 rs1185460 chr11:118943433 C/T cg23280166 chr11:118938394 VPS11 -0.52 -6.6 -0.38 2.22e-10 Coronary artery disease; CESC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg13628971 chr7:2884303 GNA12 0.59 7.53 0.42 8.17e-13 Height; CESC cis rs854765 0.583 rs7207395 chr17:17819335 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.51 6.57 0.37 2.65e-10 Total body bone mineral density; CESC cis rs9457247 1.000 rs400176 chr6:167406238 T/C cg07741184 chr6:167504864 NA 0.29 5.31 0.31 2.32e-7 Crohn's disease; CESC cis rs8070624 0.543 rs4299203 chr17:17878159 T/G cg09796270 chr17:17721594 SREBF1 0.43 5.68 0.33 3.48e-8 Total body bone mineral density; CESC cis rs2730245 0.527 rs924910 chr7:158672272 C/T cg24397884 chr7:158709396 WDR60 0.85 8.81 0.48 1.67e-16 Height; CESC trans rs1814175 0.746 rs10839429 chr11:49906845 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -21.21 -0.79 4.77e-59 Height; CESC cis rs7917772 0.582 rs10883738 chr10:104321721 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 5.71 0.33 3.08e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs11792861 0.962 rs3829084 chr9:111801724 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.45 -5.71 -0.33 3.01e-8 Menarche (age at onset); CESC cis rs9457247 0.663 rs6456143 chr6:167415440 C/A cg23791538 chr6:167370224 RNASET2 -0.57 -7.68 -0.43 3e-13 Crohn's disease; CESC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg19257562 chr1:2043853 PRKCZ 0.34 5.67 0.33 3.77e-8 Height; CESC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.56 7.54 0.42 7.46e-13 Bipolar disorder; CESC cis rs7586879 0.575 rs6706316 chr2:25128351 C/G cg01884057 chr2:25150051 NA 0.37 7.06 0.4 1.44e-11 Body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04844016 chr2:65659148 SPRED2 -0.49 -7.4 -0.41 1.83e-12 Gambling; CESC cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg18512352 chr11:47633146 NA -0.59 -8.87 -0.48 1.15e-16 Subjective well-being; CESC cis rs6754311 0.731 rs12988076 chr2:136569848 C/A cg15123519 chr2:136567270 LCT 0.33 5.62 0.33 4.81e-8 Mosquito bite size; CESC cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg07636037 chr3:49044803 WDR6 1.03 19.7 0.77 7.94e-54 Parkinson's disease; CESC cis rs2033732 0.826 rs12546578 chr8:85085268 A/T cg05716166 chr8:85095498 RALYL -0.31 -5.05 -0.3 8.31e-7 Body mass index; CESC cis rs6456156 0.586 rs10946209 chr6:167480991 G/A cg23791538 chr6:167370224 RNASET2 -0.54 -7.02 -0.4 1.83e-11 Primary biliary cholangitis; CESC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg25072359 chr17:41440525 NA 0.49 6.51 0.37 3.68e-10 Menopause (age at onset); CESC cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7107174 1.000 rs11237460 chr11:78056274 G/A cg02023728 chr11:77925099 USP35 0.4 5.79 0.34 2e-8 Testicular germ cell tumor; CESC cis rs3093024 0.595 rs4412174 chr6:167476066 A/G cg07741184 chr6:167504864 NA 0.38 6.7 0.38 1.22e-10 Rheumatoid arthritis; CESC cis rs2235544 0.588 rs638749 chr1:54450490 A/G cg25741118 chr1:54482237 LDLRAD1 0.23 5.84 0.34 1.55e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs1185460 0.546 rs549893 chr11:118959732 A/G cg23280166 chr11:118938394 VPS11 -0.37 -5.27 -0.31 2.78e-7 Coronary artery disease; CESC cis rs9596863 0.950 rs6561749 chr13:54435195 G/C ch.13.53330881F chr13:54432880 NA -0.62 -5.31 -0.31 2.33e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs55788414 0.932 rs8043592 chr16:81182537 A/G cg06400318 chr16:81190750 PKD1L2 -0.59 -7.04 -0.4 1.62e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs2276314 0.857 rs28530656 chr18:33588700 C/T cg19628046 chr18:33552617 C18orf21 -0.51 -5.94 -0.34 8.89e-9 Endometriosis;Drug-induced torsades de pointes; CESC cis rs962856 0.619 rs6546298 chr2:67581853 T/G cg09028215 chr2:67624308 ETAA1 -0.44 -5.29 -0.31 2.56e-7 Pancreatic cancer; CESC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg27266027 chr21:40555129 PSMG1 0.43 5.11 0.3 6.04e-7 Cognitive function; CESC cis rs9611565 0.592 rs5758405 chr22:42076381 C/A cg06481639 chr22:41940642 POLR3H 0.6 6.3 0.36 1.21e-9 Vitiligo; CESC cis rs13223928 0.621 rs10228451 chr7:3150859 C/G cg19214707 chr7:3157722 NA 0.43 5.85 0.34 1.46e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs7818688 1.000 rs10100089 chr8:96025093 T/A cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs2645424 1.000 rs2645424 chr8:11684463 A/G cg21281001 chr8:11725306 CTSB -0.42 -5.03 -0.3 9.1e-7 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); CESC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg09365446 chr1:150670422 GOLPH3L 0.38 5.05 0.3 8.07e-7 Melanoma; CESC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.48 -0.32 9.84e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs9325144 0.647 rs35138700 chr12:38804474 C/T cg23762105 chr12:34175262 ALG10 0.46 6.04 0.35 5.29e-9 Morning vs. evening chronotype; CESC cis rs12142240 0.698 rs56063031 chr1:46825433 C/T cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs7666738 0.688 rs4632667 chr4:98748299 A/G cg05340658 chr4:99064831 C4orf37 0.55 5.64 0.33 4.29e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg06873352 chr17:61820015 STRADA -0.69 -11.9 -0.59 1.84e-26 Prudent dietary pattern; CESC cis rs2880765 0.835 rs7174323 chr15:86049719 A/C cg10818794 chr15:86012489 AKAP13 -0.34 -5.22 -0.31 3.68e-7 Coronary artery disease; CESC cis rs2629540 0.889 rs17624662 chr10:126408146 A/C cg08799069 chr10:126477246 METTL10 0.59 7.49 0.42 1.02e-12 Cocaine dependence; CESC cis rs3931020 0.671 rs1327088 chr1:75255491 A/G cg00121533 chr1:75199117 CRYZ;TYW3 0.39 5.14 0.3 5.28e-7 Resistin levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19040509 chr17:72199640 RPL38 0.46 6.57 0.37 2.69e-10 Systemic lupus erythematosus; CESC cis rs4523957 0.614 rs7219693 chr17:2061101 C/A cg16513277 chr17:2031491 SMG6 -0.7 -9.84 -0.52 1.09e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg01341218 chr17:43662625 NA 0.93 11.18 0.57 4.86e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs2727020 0.894 rs2866361 chr11:49372481 A/G cg15704280 chr7:45808275 SEPT13 -0.76 -9.38 -0.5 2.98e-18 Coronary artery disease; CESC cis rs7824557 0.602 rs10110557 chr8:11207508 T/C cg21775007 chr8:11205619 TDH 0.57 8.65 0.47 5.01e-16 Retinal vascular caliber; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19683962 chr4:108852534 CYP2U1 0.61 7.41 0.41 1.71e-12 Gut microbiome composition (summer); CESC cis rs2337406 0.714 rs7145254 chr14:107226016 A/G cg07958169 chr14:107095056 NA -0.48 -5.37 -0.31 1.7e-7 Alzheimer's disease (late onset); CESC cis rs7408868 1.000 rs2074618 chr19:15276143 C/T cg14696996 chr19:15285081 NOTCH3 1.12 11.59 0.58 2.09e-25 Pulse pressure; CESC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg02428538 chr16:24856791 SLC5A11 -0.6 -6.06 -0.35 4.63e-9 Intelligence (multi-trait analysis); CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg08587820 chr3:5020949 BHLHE40 0.48 6.45 0.37 5.28e-10 Positive affect; CESC cis rs910316 0.737 rs175065 chr14:75494983 T/C cg15467112 chr14:75489610 MLH3 -0.34 -5.14 -0.3 5.43e-7 Height; CESC cis rs3806933 0.522 rs11241095 chr5:110439509 A/G cg04022379 chr5:110408740 TSLP 0.46 7.55 0.42 6.96e-13 Eosinophilic esophagitis; CESC cis rs11122272 0.735 rs2790878 chr1:231534390 T/C cg06096015 chr1:231504339 EGLN1 0.39 5.45 0.32 1.16e-7 Hemoglobin concentration; CESC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg00612595 chr21:47717864 NA 0.36 5.08 0.3 7.06e-7 Testicular germ cell tumor; CESC cis rs1847202 0.859 rs4566476 chr3:72948995 G/C cg25664220 chr3:72788482 NA -0.37 -5.46 -0.32 1.08e-7 Motion sickness; CESC cis rs7103648 0.897 rs35032070 chr11:47408592 G/A cg03711944 chr11:47377212 SPI1 -0.36 -5.8 -0.34 1.85e-8 Diastolic blood pressure;Systolic blood pressure; CESC cis rs829661 0.532 rs7602714 chr2:30789607 C/G cg12454169 chr2:30669597 LCLAT1 -0.4 -5.07 -0.3 7.51e-7 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg05564831 chr3:52568323 NT5DC2 0.47 7.35 0.41 2.54e-12 Bipolar disorder; CESC cis rs9486715 1.000 rs9398148 chr6:97063555 A/G cg06623918 chr6:96969491 KIAA0776 -0.89 -13.28 -0.63 3.27e-31 Headache; CESC cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg10523679 chr1:76189770 ACADM 0.75 10.09 0.53 1.83e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg08859206 chr1:53392774 SCP2 -0.64 -8.55 -0.47 9.9e-16 Monocyte count; CESC cis rs2380220 0.576 rs4498363 chr6:96042338 A/C cg04719120 chr6:96025338 MANEA 0.62 6.61 0.38 2.14e-10 Behavioural disinhibition (generation interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15801215 chr6:130341195 L3MBTL3 -0.6 -6.25 -0.36 1.59e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09266924 chr15:29034669 NA 0.42 6.11 0.35 3.51e-9 Fibrinogen levels; CESC cis rs2262909 0.548 rs7249672 chr19:22301523 C/T cg07498013 chr19:22123504 NA -0.32 -5.06 -0.3 7.86e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs7086627 0.515 rs11202959 chr10:82209672 A/G cg03267442 chr10:82210566 NA -0.34 -5.6 -0.33 5.45e-8 Post bronchodilator FEV1; CESC cis rs7824557 0.806 rs6601574 chr8:11094885 G/A cg21775007 chr8:11205619 TDH -0.36 -5.22 -0.31 3.7e-7 Retinal vascular caliber; CESC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg04317338 chr11:64019027 PLCB3 0.41 5.11 0.3 6.03e-7 Platelet count; CESC cis rs4919044 0.756 rs835257 chr10:94779801 T/A cg26979504 chr10:94451518 HHEX -0.47 -5.15 -0.3 5.16e-7 Coronary artery disease; CESC cis rs950776 0.518 rs12903129 chr15:78819606 C/T cg24631222 chr15:78858424 CHRNA5 -0.4 -5.2 -0.3 4.08e-7 Sudden cardiac arrest; CESC cis rs3026101 0.578 rs55747983 chr17:5297742 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs9325144 0.555 rs2387847 chr12:38687434 C/T cg26384229 chr12:38710491 ALG10B 0.58 8.59 0.47 7.74e-16 Morning vs. evening chronotype; CESC cis rs6032067 0.632 rs62208389 chr20:43794783 A/T cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.55 0.42 7.15e-13 Bipolar disorder; CESC cis rs7937682 0.889 rs493865 chr11:111495178 A/C cg22437258 chr11:111473054 SIK2 0.71 9.55 0.51 8.99e-19 Primary sclerosing cholangitis; CESC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg04414720 chr1:150670196 GOLPH3L 0.63 9.03 0.48 3.76e-17 Tonsillectomy; CESC cis rs7772486 0.875 rs10872582 chr6:146373061 G/A cg05347473 chr6:146136440 FBXO30 0.48 6.46 0.37 4.85e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs8018808 0.935 rs11627016 chr14:77881138 T/C cg20045696 chr14:77926864 AHSA1 0.42 5.84 0.34 1.56e-8 Myeloid white cell count; CESC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.53 0.81 1.67e-63 Prudent dietary pattern; CESC cis rs7833986 0.501 rs2953911 chr8:56948009 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 6.89e-13 Height; CESC cis rs8180040 1.000 rs811115 chr3:47322133 C/T cg27129171 chr3:47204927 SETD2 0.66 10.09 0.53 1.82e-20 Colorectal cancer; CESC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg09913183 chr17:42254507 C17orf65;ASB16 0.65 8.58 0.47 8.13e-16 Total body bone mineral density; CESC cis rs2262909 0.925 rs404822 chr19:22215967 A/C cg11619707 chr19:22235551 ZNF257 -0.36 -5.84 -0.34 1.5e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg11764359 chr7:65958608 NA 0.8 8.97 0.48 5.49e-17 Aortic root size; CESC cis rs698833 0.620 rs1067354 chr2:44663675 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.03 0.3 8.86e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg16049864 chr8:95962084 TP53INP1 -0.65 -11.35 -0.57 1.31e-24 Type 2 diabetes; CESC trans rs2018683 0.707 rs1021690 chr7:28974488 A/G cg19402173 chr7:128379420 CALU -0.49 -6.51 -0.37 3.68e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs3857536 0.566 rs208463 chr6:66913962 T/A cg07460842 chr6:66804631 NA -0.62 -7.72 -0.43 2.4e-13 Blood trace element (Cu levels); CESC cis rs4901847 0.643 rs7153396 chr14:58596356 C/T cg15908186 chr14:58618357 C14orf37 -0.35 -5.19 -0.3 4.23e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.24 -0.36 1.7e-9 Total body bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25228510 chr10:62538235 CDK1;CDC2 0.44 6.24 0.36 1.68e-9 Gut microbiota (bacterial taxa); CESC cis rs3762637 0.882 rs7630833 chr3:122190424 C/T cg24169773 chr3:122142474 KPNA1 -0.53 -6.17 -0.35 2.56e-9 LDL cholesterol levels; CESC cis rs10484885 0.878 rs72921959 chr6:90591326 C/G cg13799429 chr6:90582589 CASP8AP2 -0.8 -7.56 -0.42 6.5e-13 QRS interval (sulfonylurea treatment interaction); CESC cis rs6732160 0.691 rs4536673 chr2:73413462 A/T cg01422370 chr2:73384389 NA 0.42 7.15 0.4 8.6e-12 Intelligence (multi-trait analysis); CESC cis rs820218 0.962 rs820129 chr17:73668107 A/G cg01592526 chr17:73663357 RECQL5;SAP30BP 0.47 6.09 0.35 3.9e-9 Rotator cuff tears; CESC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg04267008 chr7:1944627 MAD1L1 -0.49 -5.91 -0.34 1.03e-8 Bipolar disorder and schizophrenia; CESC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC trans rs61931739 0.500 rs11053066 chr12:34185318 G/A cg26384229 chr12:38710491 ALG10B 0.65 9.11 0.49 2.1e-17 Morning vs. evening chronotype; CESC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg23102388 chr7:1867652 MAD1L1 -0.34 -5.11 -0.3 6.07e-7 Bipolar disorder and schizophrenia; CESC trans rs208520 0.634 rs3909071 chr6:66836947 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.96 -12.54 -0.61 1.29e-28 Exhaled nitric oxide output; CESC cis rs6964587 0.869 rs10256780 chr7:91527176 T/A cg17063962 chr7:91808500 NA -0.54 -7.24 -0.41 4.76e-12 Breast cancer; CESC cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg07636037 chr3:49044803 WDR6 1.08 19.78 0.77 4.02e-54 Parkinson's disease; CESC cis rs6424115 0.729 rs561733 chr1:24049595 T/G cg15997130 chr1:24165203 NA 0.42 5.61 0.33 4.99e-8 Immature fraction of reticulocytes; CESC cis rs6060717 0.610 rs2794382 chr20:34613651 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -7.92 -0.44 6.36e-14 Hip circumference adjusted for BMI; CESC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg08470875 chr2:26401718 FAM59B 0.76 8.06 0.44 2.69e-14 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs2413546 chr22:39107001 G/A cg06022373 chr22:39101656 GTPBP1 0.91 14.57 0.67 9.91e-36 Menopause (age at onset); CESC cis rs3092073 0.624 rs11696623 chr20:44580380 C/T cg00981651 chr20:44574847 PCIF1 0.37 5.51 0.32 8.6e-8 Intelligence (multi-trait analysis); CESC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg23281280 chr6:28129359 ZNF389 0.49 6.54 0.37 3.24e-10 Parkinson's disease; CESC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg12412775 chr1:25698385 RHCE -0.31 -5.55 -0.32 6.93e-8 Plateletcrit;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24931596 chr1:109968772 PSMA5 0.6 7.09 0.4 1.21e-11 Gut microbiome composition (summer); CESC trans rs6445797 0.632 rs4681963 chr3:56687637 C/T cg15444621 chr13:113611794 NA 0.34 6.08 0.35 4.13e-9 Gastritis; CESC cis rs13102973 0.965 rs11730310 chr4:135861925 A/G cg14419869 chr4:135874104 NA 0.34 5.37 0.31 1.72e-7 Subjective well-being; CESC cis rs3733585 0.673 rs6843873 chr4:9958788 A/C cg02734326 chr4:10020555 SLC2A9 -0.43 -5.99 -0.35 6.72e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg22508957 chr16:3507546 NAT15 0.57 9.5 0.5 1.31e-18 Tuberculosis; CESC cis rs1975974 1.000 rs4889732 chr17:21721443 T/C cg18423549 chr17:21743878 NA -0.5 -6.94 -0.39 2.92e-11 Psoriasis; CESC cis rs10131894 0.635 rs174997 chr14:75434806 G/A cg11812906 chr14:75593930 NEK9 -0.67 -10.05 -0.53 2.41e-20 Coronary artery disease; CESC trans rs7937682 0.889 rs564086 chr11:111501079 C/G cg18187862 chr3:45730750 SACM1L 0.5 6.39 0.37 7.26e-10 Primary sclerosing cholangitis; CESC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09036558 chr16:69973001 WWP2 -0.68 -7.8 -0.43 1.43e-13 Gut microbiome composition (summer); CESC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg24733560 chr20:60626293 TAF4 0.45 6.54 0.37 3.1e-10 Body mass index; CESC cis rs11166629 1.000 rs935119 chr8:135638353 C/T cg27224718 chr8:135614730 ZFAT -0.46 -5.65 -0.33 4.21e-8 Smoking quantity; CESC cis rs12142240 0.698 rs4372193 chr1:46853233 G/T cg10495392 chr1:46806563 NSUN4 0.56 6.15 0.35 2.86e-9 Menopause (age at onset); CESC cis rs7267979 1.000 rs422844 chr20:25445591 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.57 0.73 2.33e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs4919694 1.000 rs76892505 chr10:104719290 G/A cg04362960 chr10:104952993 NT5C2 0.76 5.99 0.35 6.7e-9 Arsenic metabolism; CESC cis rs56104184 0.775 rs55981795 chr19:49401952 A/C cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg09658497 chr7:2847517 GNA12 -0.42 -5.69 -0.33 3.35e-8 Height; CESC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg14196790 chr5:131705035 SLC22A5 0.34 5.16 0.3 4.96e-7 Breast cancer;Mosquito bite size; CESC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg06494592 chr3:125709126 NA -0.51 -5.46 -0.32 1.12e-7 Blood pressure (smoking interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg05719672 chr15:91446576 MAN2A2 0.43 6.18 0.35 2.44e-9 Systemic lupus erythematosus; CESC cis rs919433 0.963 rs1896854 chr2:198147776 G/T cg10820045 chr2:198174542 NA -0.41 -6.28 -0.36 1.36e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs5758659 0.652 rs133336 chr22:42416303 C/T cg04733989 chr22:42467013 NAGA 0.4 5.32 0.31 2.26e-7 Cognitive function; CESC cis rs7103648 0.630 rs7934481 chr11:47883337 C/T cg10504702 chr11:47789108 FNBP4 0.42 5.23 0.31 3.48e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs28655083 0.957 rs2171096 chr16:77079043 T/C cg01753188 chr16:77233325 SYCE1L;MON1B -0.4 -5.24 -0.31 3.21e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7512552 0.809 rs1694377 chr1:150293153 A/G cg15654264 chr1:150340011 RPRD2 0.41 5.31 0.31 2.31e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs13004237 1 rs13004237 chr2:172833139 A/G cg13550731 chr2:172543902 DYNC1I2 -0.73 -10.52 -0.54 7.25e-22 Schizophrenia; CESC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg24503407 chr1:205819492 PM20D1 0.39 5.33 0.31 2.13e-7 Prostate-specific antigen levels; CESC cis rs2380220 0.606 rs9488080 chr6:96006973 A/G cg15832292 chr6:96025679 MANEA 0.63 7.18 0.4 6.98e-12 Behavioural disinhibition (generation interaction); CESC cis rs57506017 0.585 rs1468802 chr7:12276011 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.24 0.31 3.35e-7 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21581312 chr15:35529473 LOC723972 -0.66 -7.82 -0.43 1.27e-13 Gut microbiome composition (summer); CESC cis rs3862260 0.509 rs3795662 chr1:120165135 G/T cg16322792 chr1:120165303 ZNF697 0.58 10.95 0.56 2.82e-23 Systemic lupus erythematosus; CESC cis rs1691799 0.867 rs1168311 chr12:66725912 A/C cg16791601 chr12:66731901 HELB 0.72 12.31 0.6 7.35e-28 White blood cell count (basophil); CESC cis rs75229567 0.717 rs17107156 chr12:70234066 A/G cg10114359 chr12:70132523 RAB3IP -0.84 -6.37 -0.36 8.36e-10 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs6690583 0.573 rs7547317 chr1:85456961 T/G cg22153463 chr1:85462885 MCOLN2 0.77 7.18 0.4 6.91e-12 Serum sulfate level; CESC cis rs4629180 0.675 rs10183203 chr2:102095080 C/T cg04415270 chr2:102091202 RFX8 0.33 5.74 0.33 2.63e-8 Chronic rhinosinusitis with nasal polyps; CESC cis rs2014572 0.967 rs10421632 chr19:57764770 G/A cg24459738 chr19:57751996 ZNF805 -0.53 -7.57 -0.42 6.02e-13 Hyperactive-impulsive symptoms; CESC cis rs763121 0.853 rs2281021 chr22:39064667 T/C cg06544989 chr22:39130855 UNC84B 0.48 8.4 0.46 2.69e-15 Menopause (age at onset); CESC cis rs2236918 1.000 rs2797605 chr1:242025245 A/T cg17736920 chr1:242011382 EXO1 0.71 9.05 0.49 3.1e-17 Menopause (age at onset); CESC cis rs12477438 0.520 rs6542865 chr2:99764521 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.46 0.69 7.45e-39 Chronic sinus infection; CESC cis rs1559088 0.847 rs2287680 chr19:33608566 A/G cg17764715 chr19:33622953 WDR88 -0.47 -6.05 -0.35 4.91e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs74181299 0.620 rs6546123 chr2:65303582 T/C cg05010058 chr2:65284262 CEP68 -0.32 -5.33 -0.31 2.1e-7 Pulse pressure; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg02664216 chr12:19592651 AEBP2 -0.45 -6.02 -0.35 5.78e-9 Height; CESC cis rs3820928 0.874 rs116652884 chr2:227902285 C/T cg05526886 chr2:227700861 RHBDD1 -0.45 -5.66 -0.33 3.98e-8 Pulmonary function; CESC cis rs6598955 0.724 rs7526545 chr1:26569990 C/A cg00852783 chr1:26633632 UBXN11 0.42 6.22 0.36 1.89e-9 Obesity-related traits; CESC cis rs910316 0.591 rs7157158 chr14:75457238 A/G cg08847533 chr14:75593920 NEK9 0.9 15.58 0.69 2.7e-39 Height; CESC cis rs6866344 0.697 rs17184281 chr5:178127563 G/A cg10224037 chr5:178157518 ZNF354A 0.68 7.51 0.42 8.94e-13 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.13.1524792R chr13:99552827 DOCK9 -0.51 -6.11 -0.35 3.45e-9 Gut microbiome composition (summer); CESC cis rs4555082 0.874 rs56263609 chr14:105756944 C/T cg27165867 chr14:105738592 BRF1 -0.5 -5.2 -0.3 4.05e-7 Mean platelet volume;Platelet distribution width; CESC cis rs2625529 0.504 rs11072349 chr15:72464471 T/C cg16672083 chr15:72433130 SENP8 0.45 6.79 0.39 7.29e-11 Red blood cell count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19560052 chr20:60813453 OSBPL2 0.46 6.0 0.35 6.59e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7267979 1.000 rs6050626 chr20:25428261 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 2.94e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg04267008 chr7:1944627 MAD1L1 -0.71 -9.05 -0.49 3.25e-17 Bipolar disorder and schizophrenia; CESC cis rs80130819 0.515 rs1476608 chr12:48493731 C/T cg05342945 chr12:48394962 COL2A1 -0.5 -5.87 -0.34 1.28e-8 Prostate cancer; CESC cis rs12477438 0.520 rs2516827 chr2:99772565 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.81 0.7 4.17e-40 Chronic sinus infection; CESC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs2658782 0.666 rs2925361 chr11:93098823 G/A cg15737290 chr11:93063684 CCDC67 0.57 7.26 0.41 4.36e-12 Pulmonary function decline; CESC cis rs2228479 0.850 rs11649100 chr16:89798179 A/G cg00800038 chr16:89945340 TCF25 -0.74 -5.68 -0.33 3.6e-8 Skin colour saturation; CESC cis rs1559088 0.546 rs11881543 chr19:33559372 T/G cg27124370 chr19:33622961 WDR88 0.54 7.48 0.42 1.13e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4072980 0.545 rs12120737 chr1:38422544 C/T cg18451016 chr1:38461880 NA 0.4 5.67 0.33 3.78e-8 Coronary artery disease; CESC cis rs2361718 0.521 rs2361724 chr17:78099114 G/A cg27427491 chr17:78079615 GAA -0.4 -5.88 -0.34 1.2e-8 Yeast infection; CESC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.38 0.36 7.99e-10 Bipolar disorder; CESC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg18758796 chr5:131593413 PDLIM4 0.5 7.41 0.41 1.74e-12 Acylcarnitine levels; CESC cis rs2730245 0.550 rs2657364 chr7:158683825 T/C cg24397884 chr7:158709396 WDR60 0.82 12.85 0.62 1.06e-29 Height; CESC cis rs2228479 0.850 rs1800355 chr16:89813194 C/T cg04013166 chr16:89971882 TCF25 0.78 6.65 0.38 1.72e-10 Skin colour saturation; CESC cis rs17376456 0.877 rs7701011 chr5:93311456 G/A cg21475434 chr5:93447410 FAM172A 0.76 6.88 0.39 4.31e-11 Diabetic retinopathy; CESC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.31 -5.14 -0.3 5.46e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs2439831 0.681 rs3742969 chr15:43621947 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.12 0.63 1.26e-30 Lung cancer in ever smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19408915 chr1:172412924 C1orf105;PIGC 0.53 6.26 0.36 1.5e-9 Gut microbiome composition (summer); CESC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg08027265 chr7:2291960 NA -0.41 -6.4 -0.37 6.89e-10 Schizophrenia; CESC cis rs765787 0.530 rs16941017 chr15:45543281 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -7.4 -0.41 1.83e-12 Uric acid levels; CESC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg19770292 chr5:1868693 NA 0.3 5.05 0.3 8.04e-7 Cardiovascular disease risk factors; CESC cis rs4595586 0.525 rs12809307 chr12:39365927 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.57 0.42 6.23e-13 Morning vs. evening chronotype; CESC cis rs2380220 0.576 rs7751219 chr6:96018915 G/A cg23517279 chr6:96025343 MANEA 0.54 5.29 0.31 2.57e-7 Behavioural disinhibition (generation interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26865258 chr19:47551991 TMEM160 0.58 6.11 0.35 3.54e-9 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg22800045 chr5:56110881 MAP3K1 0.83 9.99 0.52 3.69e-20 Initial pursuit acceleration; CESC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg12412775 chr1:25698385 RHCE 0.32 5.7 0.33 3.14e-8 Erythrocyte sedimentation rate; CESC cis rs2249694 0.960 rs7075572 chr10:135404358 T/C cg20169779 chr10:135381914 SYCE1 -0.39 -5.64 -0.33 4.42e-8 Obesity-related traits; CESC cis rs1879734 0.689 rs12097598 chr1:54170801 C/G cg23596471 chr1:54105337 GLIS1 0.35 5.58 0.32 5.97e-8 Mitral valve prolapse; CESC cis rs6831352 0.918 rs1126672 chr4:100047812 G/A cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs34779708 0.931 rs11010067 chr10:35295431 C/G cg03585969 chr10:35415529 CREM -0.74 -9.87 -0.52 8.82e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs116095464 0.558 rs13357299 chr5:242211 T/C cg22496380 chr5:211416 CCDC127 -0.72 -8.46 -0.46 1.87e-15 Breast cancer; CESC cis rs922182 0.569 rs7180050 chr15:64263784 G/A cg24729988 chr15:64271149 DAPK2 0.4 5.32 0.31 2.21e-7 Blood protein levels; CESC cis rs2760061 0.626 rs592736 chr1:228116831 A/G cg01973587 chr1:228161476 NA 0.33 5.19 0.3 4.15e-7 Diastolic blood pressure; CESC cis rs7927771 0.524 rs11039392 chr11:47798753 A/G cg18512352 chr11:47633146 NA 0.34 5.24 0.31 3.35e-7 Subjective well-being; CESC cis rs79349575 0.783 rs59270107 chr17:47026185 A/T cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs9611565 0.525 rs9611549 chr22:41705909 C/G cg06634786 chr22:41940651 POLR3H -0.5 -5.35 -0.31 1.91e-7 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03915945 chr6:155635934 TFB1M 0.61 7.37 0.41 2.23e-12 Gut microbiome composition (summer); CESC cis rs12476592 0.602 rs10469945 chr2:63816776 T/C cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.81 0.34 1.79e-8 Bipolar disorder; CESC cis rs6582630 0.638 rs12425531 chr12:38550387 A/G cg26384229 chr12:38710491 ALG10B -0.39 -5.19 -0.3 4.22e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs67311347 0.910 rs7617361 chr3:40373259 G/T cg09455208 chr3:40491958 NA 0.45 7.96 0.44 5.05e-14 Renal cell carcinoma; CESC cis rs854765 0.583 rs4413022 chr17:17858280 G/C cg16928487 chr17:17741425 SREBF1 -0.57 -9.58 -0.51 7.39e-19 Total body bone mineral density; CESC cis rs6687430 0.532 rs9430149 chr1:10612820 G/C cg20482658 chr1:10539492 PEX14 0.39 8.02 0.44 3.52e-14 Hand grip strength; CESC cis rs1790761 0.505 rs7938563 chr11:67304131 A/G cg00290607 chr11:67383545 NA -0.38 -5.63 -0.33 4.55e-8 Mean corpuscular volume; CESC cis rs910316 0.737 rs108622 chr14:75481908 A/G cg16144293 chr14:75469539 EIF2B2 0.39 5.11 0.3 6.28e-7 Height; CESC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs6424115 1.000 rs4237 chr1:24114129 C/T cg15997130 chr1:24165203 NA 0.5 7.05 0.4 1.55e-11 Immature fraction of reticulocytes; CESC cis rs3824867 0.920 rs7107853 chr11:47453518 T/C cg20307385 chr11:47447363 PSMC3 -0.49 -5.94 -0.34 9.16e-9 Mean corpuscular hemoglobin; CESC cis rs2354432 0.607 rs11587707 chr1:146707186 T/C cg25205988 chr1:146714368 CHD1L -1.02 -8.03 -0.44 3.16e-14 Mitochondrial DNA levels; CESC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg07507251 chr3:52567010 NT5DC2 0.42 6.12 0.35 3.32e-9 Bipolar disorder; CESC cis rs7772486 0.875 rs2224121 chr6:146343214 G/A cg23711669 chr6:146136114 FBXO30 0.84 12.07 0.6 4.9e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs10489525 0.599 rs7516121 chr1:115604317 A/G cg01522456 chr1:115632236 TSPAN2 0.47 5.61 0.33 5.03e-8 Autism; CESC trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.43 -0.46 2.17e-15 Intelligence (multi-trait analysis); CESC cis rs367943 1.000 rs348948 chr5:112822452 A/C cg12552261 chr5:112820674 MCC -0.63 -7.96 -0.44 4.96e-14 Type 2 diabetes; CESC cis rs897080 0.515 rs1067333 chr2:44626710 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.82 0.34 1.67e-8 Height; CESC cis rs36051895 0.622 rs12686652 chr9:5071942 C/G cg02405213 chr9:5042618 JAK2 -0.51 -6.19 -0.36 2.28e-9 Pediatric autoimmune diseases; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06931193 chr6:107781130 PDSS2 0.56 6.43 0.37 5.83e-10 Gut microbiome composition (summer); CESC cis rs1707322 0.964 rs10437063 chr1:46273666 G/A cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1059312 0.966 rs2291349 chr12:129284248 T/C cg09035930 chr12:129282057 SLC15A4 0.78 11.04 0.56 1.46e-23 Systemic lupus erythematosus; CESC cis rs910316 0.737 rs175084 chr14:75519175 C/T cg16144293 chr14:75469539 EIF2B2 0.39 5.14 0.3 5.39e-7 Height; CESC cis rs11971779 0.793 rs4732366 chr7:139027845 G/C cg07862535 chr7:139043722 LUC7L2 0.49 5.55 0.32 6.82e-8 Diisocyanate-induced asthma; CESC cis rs34779708 0.931 rs35126129 chr10:35452141 G/A cg04310649 chr10:35416472 CREM -0.53 -6.4 -0.37 7.07e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg04772025 chr11:68637568 NA 0.53 5.97 0.34 7.49e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7178572 0.568 rs12913233 chr15:77543297 C/T cg22256960 chr15:77711686 NA -0.53 -6.78 -0.38 7.79e-11 Type 2 diabetes; CESC cis rs10185178 1.000 rs10185178 chr2:171356274 A/G cg21128415 chr2:171359116 MYO3B -1.07 -8.89 -0.48 9.93e-17 Coronary artery aneurysm in Kawasaki disease; CESC cis rs963731 0.649 rs4142729 chr2:39222915 A/G cg04010122 chr2:39346883 SOS1 -0.77 -5.4 -0.31 1.51e-7 Corticobasal degeneration; CESC cis rs7631605 0.905 rs11711968 chr3:37224967 C/G cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.24 -0.31 3.21e-7 Cerebrospinal P-tau181p levels; CESC cis rs1941023 0.503 rs11230288 chr11:60128968 G/A cg08716584 chr11:60157161 MS4A7 -0.51 -8.18 -0.45 1.2e-14 Congenital heart disease (maternal effect); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17424859 chr6:71319002 NA -0.62 -7.41 -0.41 1.72e-12 Gut microbiome composition (summer); CESC cis rs71403859 0.803 rs17282500 chr16:71633653 C/A cg08717414 chr16:71523259 ZNF19 -0.79 -6.93 -0.39 3.26e-11 Post bronchodilator FEV1; CESC cis rs7312933 0.558 rs61926593 chr12:42818912 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.41 0.37 6.61e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7100689 0.646 rs10749579 chr10:82140959 C/T cg00277334 chr10:82204260 NA -0.59 -7.81 -0.43 1.36e-13 Post bronchodilator FEV1; CESC cis rs6748734 0.600 rs10933510 chr2:241826754 G/A cg04034577 chr2:241836375 C2orf54 -0.29 -5.08 -0.3 7.16e-7 Urinary metabolites; CESC cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.45 5.79 0.34 1.99e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3126085 0.935 rs7537637 chr1:152223335 T/A cg03465714 chr1:152285911 FLG -0.42 -5.16 -0.3 4.84e-7 Atopic dermatitis; CESC cis rs2933343 0.700 rs2249514 chr3:128643812 C/T cg25356066 chr3:128598488 ACAD9 0.6 8.44 0.46 2.09e-15 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02620388 chr7:100271115 GNB2 0.55 6.34 0.36 1e-9 Gut microbiome composition (summer); CESC cis rs7937682 0.921 rs4616071 chr11:111440865 C/G cg09085632 chr11:111637200 PPP2R1B 0.91 10.72 0.55 1.59e-22 Primary sclerosing cholangitis; CESC cis rs826838 0.872 rs826878 chr12:39088837 A/T cg13010199 chr12:38710504 ALG10B -0.37 -5.04 -0.3 8.58e-7 Heart rate; CESC cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg25405998 chr7:65216604 CCT6P1 0.51 5.52 0.32 8.13e-8 Aortic root size; CESC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg24060327 chr5:131705240 SLC22A5 -0.75 -10.45 -0.54 1.25e-21 Blood metabolite levels; CESC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg18099408 chr3:52552593 STAB1 -0.3 -5.13 -0.3 5.48e-7 Electroencephalogram traits; CESC cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 1.000 rs11039390 chr11:47796295 C/G cg05585544 chr11:47624801 NA -0.5 -7.86 -0.43 9.61e-14 Subjective well-being; CESC cis rs1707322 1.000 rs11211237 chr1:46447329 G/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs897080 0.515 rs1067398 chr2:44678882 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.51 0.32 8.33e-8 Height; CESC cis rs7937682 0.640 rs587010 chr11:111425658 C/A cg09085632 chr11:111637200 PPP2R1B -0.76 -10.13 -0.53 1.34e-20 Primary sclerosing cholangitis; CESC cis rs2109514 0.902 rs28495552 chr7:116113744 C/G cg12739419 chr7:116140593 CAV2 -0.38 -6.85 -0.39 5.19e-11 Prevalent atrial fibrillation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21140054 chr3:42632404 SS18L2 0.54 6.29 0.36 1.29e-9 Gut microbiome composition (summer); CESC cis rs9640161 0.742 rs2159236 chr7:150017214 A/G cg10018233 chr7:150070692 REPIN1 0.46 7.36 0.41 2.3e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg07677032 chr17:61819896 STRADA -0.46 -6.25 -0.36 1.63e-9 Prudent dietary pattern; CESC cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg00290607 chr11:67383545 NA -0.39 -5.38 -0.31 1.61e-7 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17895870 chr19:16254474 HSH2D 0.57 6.7 0.38 1.24e-10 Gut microbiome composition (summer); CESC trans rs123509 0.874 rs339683 chr3:42788511 G/T cg22035501 chr5:112073398 APC 0.57 6.11 0.35 3.62e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10252516 chr19:56671462 ZNF444 0.49 6.42 0.37 6.3e-10 Fibrinogen levels; CESC cis rs5769765 0.740 rs2103932 chr22:50272515 A/G cg26441486 chr22:50317300 CRELD2 -0.38 -5.31 -0.31 2.32e-7 Schizophrenia; CESC cis rs3820068 0.581 rs72645864 chr1:15921153 C/T cg17385448 chr1:15911702 AGMAT 0.42 6.72 0.38 1.13e-10 Systolic blood pressure; CESC cis rs6736093 1.000 rs7604403 chr2:112656652 G/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.18 -0.3 4.48e-7 Coronary artery disease; CESC cis rs250677 0.522 rs1432801 chr5:148390979 T/C cg18129178 chr5:148520854 ABLIM3 -0.47 -5.22 -0.31 3.57e-7 Breast cancer; CESC cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg18876405 chr7:65276391 NA 0.49 6.52 0.37 3.5e-10 Aortic root size; CESC trans rs12265790 1.000 rs11253670 chr10:15928012 G/A cg03460745 chr3:171966142 FNDC3B 0.75 6.19 0.36 2.25e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; CESC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs9467711 0.606 rs28360517 chr6:26602453 A/G cg12826209 chr6:26865740 GUSBL1 0.67 6.06 0.35 4.68e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg21770322 chr7:97807741 LMTK2 0.54 7.91 0.44 6.97e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs1790761 0.658 rs684928 chr11:67329742 G/A cg24690094 chr11:67383802 NA 0.36 5.85 0.34 1.43e-8 Mean corpuscular volume; CESC cis rs67366981 0.925 rs66846709 chr14:77692812 G/A cg22824376 chr14:77648248 TMEM63C 0.64 5.32 0.31 2.23e-7 Obsessive-compulsive symptoms; CESC cis rs7772486 0.875 rs2814873 chr6:146308932 T/C cg05347473 chr6:146136440 FBXO30 0.56 7.37 0.41 2.14e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.68 -7.7 -0.43 2.76e-13 Gut microbiome composition (summer); CESC cis rs1707322 0.656 rs9429172 chr1:46092476 C/G cg03146154 chr1:46216737 IPP -0.79 -11.05 -0.56 1.36e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs826838 0.585 rs4363678 chr12:38624514 G/A cg26384229 chr12:38710491 ALG10B 0.46 6.6 0.38 2.27e-10 Heart rate; CESC cis rs9611565 0.512 rs9611672 chr22:42209922 A/G cg03806693 chr22:41940476 POLR3H -1.18 -13.57 -0.64 3.29e-32 Vitiligo; CESC cis rs7264396 0.790 rs6060516 chr20:34214368 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.51 -0.58 4.04e-25 Total cholesterol levels; CESC cis rs7412746 0.658 rs4970987 chr1:150949682 T/C cg04414720 chr1:150670196 GOLPH3L 0.49 6.45 0.37 5.22e-10 Melanoma; CESC cis rs11711311 0.911 rs9817327 chr3:113478500 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.24 0.53 5.93e-21 IgG glycosylation; CESC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs35110281 0.627 rs56369437 chr21:44970275 A/G cg01579765 chr21:45077557 HSF2BP -0.5 -8.45 -0.46 2.01e-15 Mean corpuscular volume; CESC cis rs559928 0.548 rs11231713 chr11:63931849 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.44 0.32 1.2e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs2439831 1.000 rs2256764 chr15:43735763 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.92 9.53 0.51 1.06e-18 Lung cancer in ever smokers; CESC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg08888203 chr3:10149979 C3orf24 -0.47 -5.19 -0.3 4.16e-7 Alzheimer's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22108864 chr8:26307427 NA 0.5 6.52 0.37 3.45e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs61931739 0.817 rs7963318 chr12:34244929 C/G cg19457237 chr12:34500585 NA 0.4 5.74 0.33 2.58e-8 Morning vs. evening chronotype; CESC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg22968622 chr17:43663579 NA 0.78 10.72 0.55 1.68e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7937682 0.883 rs12366001 chr11:111433916 A/G cg09085632 chr11:111637200 PPP2R1B 0.97 13.15 0.63 9.55e-31 Primary sclerosing cholangitis; CESC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.49 6.95 0.39 2.79e-11 Menopause (age at onset); CESC cis rs667920 0.557 rs35849216 chr3:136327569 C/T cg15507776 chr3:136538369 TMEM22 -0.71 -5.63 -0.33 4.58e-8 Coronary artery disease; CESC cis rs4332037 0.805 rs10278591 chr7:1921362 A/G cg23422044 chr7:1970798 MAD1L1 0.6 7.65 0.43 3.83e-13 Bipolar disorder; CESC cis rs9905704 0.718 rs72826360 chr17:56664395 T/G cg12560992 chr17:57184187 TRIM37 0.64 5.96 0.34 8.03e-9 Testicular germ cell tumor; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19273467 chr1:32110819 PEF1 0.5 6.33 0.36 1.03e-9 Gut microbiota (bacterial taxa); CESC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg11843238 chr5:131593191 PDLIM4 -0.37 -5.34 -0.31 1.99e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17838705 chr1:112298602 DDX20;C1orf183 0.6 7.46 0.42 1.26e-12 Gut microbiome composition (summer); CESC cis rs727505 1.000 rs10233385 chr7:124498707 C/G cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs3020736 0.500 rs6519306 chr22:42501217 T/C cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC cis rs4604732 0.536 rs12058821 chr1:247649651 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.42 5.34 0.31 1.98e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs1945213 0.694 rs11227113 chr11:55828024 C/T cg03929089 chr4:120376271 NA 0.76 7.23 0.41 5.06e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs12930096 1.000 rs12929430 chr16:11679467 C/T cg07439791 chr16:11680400 LITAF 0.61 6.14 0.35 2.95e-9 QT interval; CESC cis rs7733403 1 rs7733403 chr5:140154215 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.36 -0.31 1.82e-7 Schizophrenia; CESC cis rs10887741 0.646 rs12257469 chr10:89437129 G/A cg13926569 chr10:89418898 PAPSS2 0.5 8.14 0.45 1.54e-14 Exercise (leisure time); CESC cis rs12500824 0.564 rs62300855 chr4:77281889 G/C cg20311846 chr4:77356250 SHROOM3 0.37 6.88 0.39 4.32e-11 Coronary artery disease; CESC cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1023500 0.573 rs133382 chr22:42471774 C/T cg04733989 chr22:42467013 NAGA 0.79 12.05 0.59 5.98e-27 Schizophrenia; CESC cis rs7223966 1.000 rs8074771 chr17:61735865 C/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.16 -0.3 4.73e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg03709012 chr19:19516395 GATAD2A -0.98 -14.29 -0.66 1.02e-34 Tonsillectomy; CESC cis rs7116495 0.786 rs610004 chr11:71797939 C/T cg26138937 chr11:71823887 C11orf51 -0.86 -7.03 -0.4 1.75e-11 Severe influenza A (H1N1) infection; CESC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg24549020 chr5:56110836 MAP3K1 0.67 6.19 0.36 2.25e-9 Type 2 diabetes; CESC cis rs9926296 0.744 rs154657 chr16:89708096 A/G cg04287289 chr16:89883240 FANCA 0.47 5.9 0.34 1.09e-8 Vitiligo; CESC cis rs2239547 0.522 rs6770957 chr3:52995416 T/C cg11645453 chr3:52864694 ITIH4 0.33 5.55 0.32 7.04e-8 Schizophrenia; CESC cis rs561341 1.000 rs527256 chr17:30321293 C/G cg12193833 chr17:30244370 NA -0.72 -6.68 -0.38 1.42e-10 Hip circumference adjusted for BMI; CESC cis rs300703 0.639 rs397719 chr2:204870 T/G cg21211680 chr2:198530 NA 0.96 10.54 0.54 6.42e-22 Blood protein levels; CESC cis rs7927771 0.524 rs6485786 chr11:47837408 G/C cg20307385 chr11:47447363 PSMC3 0.62 8.62 0.47 6.37e-16 Subjective well-being; CESC cis rs8031584 0.651 rs28664821 chr15:31172323 G/A cg08109568 chr15:31115862 NA 0.8 11.8 0.59 4.17e-26 Huntington's disease progression; CESC cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg27347728 chr4:17578864 LAP3 0.43 5.18 0.3 4.42e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg08888203 chr3:10149979 C3orf24 0.47 6.14 0.35 3.04e-9 Alzheimer's disease; CESC cis rs7851660 0.967 rs907577 chr9:100615117 C/T cg13688889 chr9:100608707 NA -0.69 -10.57 -0.54 4.92e-22 Strep throat; CESC cis rs863345 0.604 rs10908661 chr1:158466990 T/A cg12129480 chr1:158549410 OR10X1 -0.33 -6.58 -0.37 2.53e-10 Pneumococcal bacteremia; CESC cis rs3820928 0.874 rs2228557 chr2:227872182 G/A cg11843606 chr2:227700838 RHBDD1 -0.47 -6.05 -0.35 4.92e-9 Pulmonary function; CESC cis rs2249625 1.000 rs2463698 chr6:72923936 A/G cg18830697 chr6:72922368 RIMS1 -0.45 -6.43 -0.37 6.06e-10 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 7.66 0.43 3.61e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg25517755 chr10:38738941 LOC399744 0.44 5.72 0.33 2.81e-8 Extrinsic epigenetic age acceleration; CESC cis rs11871801 0.517 rs645692 chr17:40701073 C/T cg14558262 chr17:40713999 COASY 0.53 6.14 0.35 3.08e-9 Crohn's disease; CESC cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg08807892 chr2:162101083 NA -0.47 -6.29 -0.36 1.31e-9 Intelligence (multi-trait analysis); CESC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -6.76 -0.38 8.51e-11 Bipolar disorder; CESC cis rs9467711 0.591 rs17586553 chr6:25928775 C/T cg21479132 chr6:26055353 NA 0.91 9.03 0.48 3.74e-17 Autism spectrum disorder or schizophrenia; CESC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs634534 0.622 rs624273 chr11:65712413 A/G cg26695010 chr11:65641043 EFEMP2 -0.44 -5.43 -0.32 1.29e-7 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs25645 0.771 rs11078936 chr17:38197914 T/C cg17467752 chr17:38218738 THRA -0.53 -6.77 -0.38 8.22e-11 Myeloid white cell count; CESC cis rs1451375 0.572 rs12666409 chr7:50634976 A/T cg14593290 chr7:50529359 DDC -0.44 -5.27 -0.31 2.79e-7 Malaria; CESC cis rs2070488 0.736 rs2070988 chr3:38437835 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.68 9.56 0.51 8.31e-19 Electrocardiographic conduction measures; CESC trans rs8073060 0.586 rs8064895 chr17:34001121 T/C cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.58 -7.57 -0.42 6.29e-13 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11653948 chr11:2421970 NA 0.55 6.59 0.38 2.43e-10 Gut microbiome composition (summer); CESC cis rs7107174 1.000 rs7116611 chr11:78030046 A/G cg02023728 chr11:77925099 USP35 0.47 6.47 0.37 4.75e-10 Testicular germ cell tumor; CESC cis rs8103278 0.507 rs62111759 chr19:46296230 A/T cg06577658 chr19:46296270 DMWD 0.47 5.59 0.33 5.5e-8 Coronary artery disease; CESC cis rs12906542 0.507 rs4395040 chr15:78282533 G/A cg22832135 chr15:78370102 TBC1D2B 0.49 5.05 0.3 8.04e-7 Breast cancer; CESC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg13206674 chr6:150067644 NUP43 -0.46 -6.67 -0.38 1.52e-10 Lung cancer; CESC cis rs34779708 0.931 rs4934709 chr10:35339324 A/C cg03585969 chr10:35415529 CREM -0.71 -9.07 -0.49 2.73e-17 Inflammatory bowel disease;Crohn's disease; CESC cis rs7647973 0.626 rs9830730 chr3:49675875 G/C cg07636037 chr3:49044803 WDR6 0.53 6.34 0.36 9.78e-10 Menarche (age at onset); CESC cis rs79839061 0.656 rs11726912 chr4:887868 A/C cg07828340 chr4:882639 GAK 1.07 8.55 0.47 9.76e-16 Intelligence (multi-trait analysis); CESC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.79 10.4 0.54 1.83e-21 Height; CESC cis rs7851660 0.809 rs12004762 chr9:100652755 A/G cg13688889 chr9:100608707 NA -0.63 -8.96 -0.48 5.96e-17 Strep throat; CESC cis rs7116495 0.609 rs2852365 chr11:71715218 T/C cg26138937 chr11:71823887 C11orf51 -1.22 -8.14 -0.45 1.52e-14 Severe influenza A (H1N1) infection; CESC trans rs3925158 0.510 rs4955398 chr3:38301161 T/C cg23247845 chr10:3679085 NA 0.61 6.0 0.35 6.39e-9 Gut microbiota (bacterial taxa); CESC cis rs938554 0.501 rs7671266 chr4:10056376 C/T cg00071950 chr4:10020882 SLC2A9 -0.68 -8.29 -0.45 5.91e-15 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15549927 chr7:153749756 DPP6 -0.48 -6.05 -0.35 4.83e-9 Gut microbiome composition (summer); CESC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.72 9.83 0.52 1.18e-19 Total body bone mineral density; CESC cis rs870825 0.616 rs3184982 chr4:185615768 T/G cg04058563 chr4:185651563 MLF1IP 0.65 7.14 0.4 9.11e-12 Blood protein levels; CESC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg09913183 chr17:42254507 C17orf65;ASB16 0.68 9.05 0.49 3.11e-17 Total body bone mineral density; CESC cis rs854765 0.551 rs12600546 chr17:17867614 A/G cg16928487 chr17:17741425 SREBF1 -0.57 -9.55 -0.51 9.29e-19 Total body bone mineral density; CESC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg26314531 chr2:26401878 FAM59B -0.62 -6.99 -0.39 2.29e-11 Gut microbiome composition (summer); CESC cis rs72781680 1.000 rs12617839 chr2:24166277 A/T cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC trans rs11098499 0.865 rs3956464 chr4:120256764 T/C cg25214090 chr10:38739885 LOC399744 0.64 9.08 0.49 2.59e-17 Corneal astigmatism; CESC cis rs9300255 0.537 rs1619561 chr12:123620268 G/C cg00376283 chr12:123451042 ABCB9 0.74 8.99 0.48 4.76e-17 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00281600 chr7:149322071 ZNF767 0.57 6.29 0.36 1.33e-9 Gut microbiome composition (summer); CESC cis rs2797160 0.935 rs12717178 chr6:126016499 G/A cg05901451 chr6:126070800 HEY2 0.45 6.45 0.37 5.3e-10 Endometrial cancer; CESC cis rs926938 0.618 rs904292 chr1:115358421 C/T cg12756093 chr1:115239321 AMPD1 0.44 5.92 0.34 9.88e-9 Autism; CESC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg17414380 chr19:19431394 KIAA0892;SF4 0.46 5.65 0.33 4.07e-8 Tonsillectomy; CESC cis rs9399135 1.000 rs6569988 chr6:135352303 C/A cg22676075 chr6:135203613 NA 0.48 6.69 0.38 1.36e-10 Red blood cell count; CESC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg05564831 chr3:52568323 NT5DC2 0.46 6.98 0.39 2.32e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17809632 chr2:27435717 SLC5A6;C2orf28 -0.55 -6.35 -0.36 9.25e-10 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs3796813 chr4:17591648 A/G cg16339924 chr4:17578868 LAP3 0.7 9.26 0.49 7.03e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8072100 0.967 rs2317826 chr17:45730899 C/T cg08085267 chr17:45401833 C17orf57 -0.43 -5.75 -0.33 2.45e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs11785400 0.793 rs11785012 chr8:143748355 G/A cg24634471 chr8:143751801 JRK 0.46 5.77 0.33 2.25e-8 Schizophrenia; CESC cis rs2737618 0.674 rs2821334 chr1:200093887 G/T cg21825944 chr1:200113062 NR5A2 -0.42 -6.36 -0.36 8.88e-10 Uric acid levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00475815 chr3:196594767 SENP5 -0.42 -6.02 -0.35 5.72e-9 Ulcerative colitis; CESC cis rs6991838 0.550 rs12335006 chr8:66531629 T/C cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs6429082 0.871 rs6675944 chr1:235572669 C/T cg26050004 chr1:235667680 B3GALNT2 0.39 5.31 0.31 2.37e-7 Adiposity; CESC cis rs5769765 0.908 rs138866 chr22:50205903 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.45 5.12 0.3 5.82e-7 Schizophrenia; CESC cis rs611744 0.870 rs634216 chr8:109174803 A/G cg21045802 chr8:109455806 TTC35 0.46 5.57 0.32 6.24e-8 Dupuytren's disease; CESC cis rs3820068 0.705 rs41486146 chr1:15900517 A/G cg17385448 chr1:15911702 AGMAT -0.39 -5.79 -0.34 1.99e-8 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05241309 chr16:67691486 ACD -0.59 -6.64 -0.38 1.8e-10 Gut microbiome composition (summer); CESC cis rs9908102 0.740 rs8078710 chr17:12910662 G/A cg26162695 chr17:12921313 ELAC2 0.52 5.71 0.33 3.04e-8 Schizophrenia; CESC cis rs1775715 0.737 rs2808072 chr10:32205504 A/T cg18675610 chr10:32216311 ARHGAP12 0.36 5.55 0.32 6.84e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs763014 0.865 rs8909 chr16:633851 T/C cg09263875 chr16:632152 PIGQ 0.65 10.73 0.55 1.53e-22 Height; CESC cis rs9733 0.715 rs7534124 chr1:150739073 C/T cg22823121 chr1:150693482 HORMAD1 -0.39 -5.85 -0.34 1.41e-8 Tonsillectomy; CESC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg08736216 chr1:53307985 ZYG11A -0.39 -6.79 -0.39 7.28e-11 Monocyte count; CESC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg07414643 chr4:187882934 NA 0.55 8.01 0.44 3.75e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg00684032 chr4:1343700 KIAA1530 0.36 5.56 0.32 6.59e-8 Longevity; CESC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg19717773 chr7:2847554 GNA12 -0.57 -8.08 -0.44 2.27e-14 Height; CESC cis rs4948523 0.530 rs11006182 chr10:60309128 G/A cg07615347 chr10:60278583 BICC1 -0.57 -8.14 -0.45 1.59e-14 Myopia; CESC cis rs2439831 0.850 rs28413704 chr15:44148427 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.43 0.42 1.45e-12 Lung cancer in ever smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07508942 chr7:5267994 WIPI2 -0.55 -6.0 -0.35 6.6e-9 Gut microbiome composition (summer); CESC cis rs2120019 0.938 rs5020842 chr15:75322310 T/C cg09165964 chr15:75287851 SCAMP5 -0.86 -10.97 -0.56 2.39e-23 Blood trace element (Zn levels); CESC cis rs9394152 0.845 rs9296092 chr6:33478496 C/T cg13560919 chr6:33536144 NA -0.48 -7.61 -0.42 4.71e-13 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs992157 0.798 rs10193383 chr2:219157692 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.02 0.48 3.81e-17 Colorectal cancer; CESC cis rs2180341 0.782 rs6912750 chr6:127723081 A/T cg27446573 chr6:127587934 RNF146 0.8 11.46 0.58 5.73e-25 Breast cancer; CESC trans rs1814175 0.645 rs11040671 chr11:49958776 G/A cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs8050907 0.744 rs28680621 chr16:4518994 G/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.93 6.54 0.37 3.14e-10 Obesity-related traits; CESC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg10351095 chr21:47802916 PCNT 0.43 5.87 0.34 1.31e-8 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 4.04e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2066819 0.892 rs112931321 chr12:56667894 C/T cg26714650 chr12:56694279 CS -1.51 -10.33 -0.54 3.09e-21 Psoriasis vulgaris; CESC cis rs796364 0.577 rs7574287 chr2:200680999 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.57 5.23 0.31 3.39e-7 Schizophrenia; CESC cis rs992157 0.735 rs13430006 chr2:219113089 A/C cg20019365 chr2:219134978 PNKD;AAMP -0.67 -9.18 -0.49 1.3e-17 Colorectal cancer; CESC cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg15556689 chr8:8085844 FLJ10661 0.64 8.72 0.47 3.04e-16 Mood instability; CESC cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg03433033 chr1:76189801 ACADM -0.58 -5.97 -0.34 7.72e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3806843 0.900 rs2337983 chr5:140136808 G/A cg26395211 chr5:140044315 WDR55 0.43 5.46 0.32 1.07e-7 Depressive symptoms (multi-trait analysis); CESC cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg18904891 chr8:8559673 CLDN23 0.73 8.11 0.45 1.94e-14 Obesity-related traits; CESC cis rs977987 0.778 rs62059846 chr16:75430809 T/A cg03315344 chr16:75512273 CHST6 0.4 5.71 0.33 3e-8 Dupuytren's disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20194871 chr2:97779411 ANKRD36 -0.47 -6.17 -0.35 2.57e-9 Asthma; CESC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg05368731 chr17:41323189 NBR1 0.79 10.96 0.56 2.64e-23 Menopause (age at onset); CESC cis rs7089973 0.624 rs11196930 chr10:116583596 C/T cg25233709 chr10:116636983 FAM160B1 0.35 5.48 0.32 1.01e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs11792861 0.591 rs2275641 chr9:111696389 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.63 9.77 0.51 1.92e-19 Menarche (age at onset); CESC cis rs9467711 0.606 rs2235251 chr6:26431982 C/T cg14345882 chr6:26364793 BTN3A2 0.61 5.84 0.34 1.56e-8 Autism spectrum disorder or schizophrenia; CESC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg06456125 chr7:65229604 NA 0.44 5.75 0.33 2.47e-8 Calcium levels; CESC cis rs3780486 0.718 rs10971418 chr9:33122024 A/C cg13443165 chr9:33130375 B4GALT1 -0.43 -5.27 -0.31 2.8e-7 IgG glycosylation; CESC cis rs11122272 0.735 rs2790885 chr1:231529925 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs12586317 0.547 rs28589276 chr14:35478865 A/G cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26606899 chr16:1802252 MAPK8IP3 0.49 6.48 0.37 4.37e-10 Fibrinogen levels; CESC cis rs11750568 0.967 rs890699 chr5:178511846 A/G cg10208897 chr5:178548229 ADAMTS2 -0.41 -5.74 -0.33 2.52e-8 Height; CESC cis rs1153858 1.000 rs12909158 chr15:45621174 A/G cg21132104 chr15:45694354 SPATA5L1 0.83 11.01 0.56 1.8e-23 Homoarginine levels; CESC trans rs2502399 0.689 rs2502372 chr6:113504554 A/G cg00285294 chr7:1089767 C7orf50 -0.35 -6.64 -0.38 1.75e-10 Plasma clusterin levels; CESC cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6459788 0.692 rs10807645 chr7:157258979 T/C cg03453431 chr7:157225567 NA 0.34 5.78 0.33 2.12e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg03934478 chr11:495069 RNH1 0.55 5.25 0.31 3.06e-7 Body mass index; CESC trans rs7672847 0.547 rs7693196 chr4:170474693 C/T cg19308436 chr1:237949471 RYR2 0.65 6.9 0.39 3.89e-11 Subjective well-being; CESC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg24549020 chr5:56110836 MAP3K1 -0.48 -6.08 -0.35 4.11e-9 Initial pursuit acceleration; CESC cis rs7621025 0.505 rs34613715 chr3:136455007 A/T cg15507776 chr3:136538369 TMEM22 -0.8 -7.14 -0.4 9.13e-12 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg06494592 chr3:125709126 NA -0.49 -5.32 -0.31 2.23e-7 Blood pressure (smoking interaction); CESC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg24531977 chr5:56204891 C5orf35 0.4 5.04 0.3 8.73e-7 Coronary artery disease; CESC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg21775979 chr11:780331 NA 0.38 5.78 0.33 2.12e-8 Breast cancer; CESC cis rs7116495 1.000 rs541022 chr11:71783056 G/A cg26138937 chr11:71823887 C11orf51 -0.72 -6.35 -0.36 9.41e-10 Severe influenza A (H1N1) infection; CESC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg18876405 chr7:65276391 NA 0.52 7.33 0.41 2.8e-12 Aortic root size; CESC cis rs6831352 0.918 rs13129488 chr4:100053025 G/T cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC trans rs9319321 0.571 rs9512419 chr13:27415593 A/T cg14332112 chr6:47277683 TNFRSF21 -0.49 -6.22 -0.36 1.97e-9 Asthma (toluene diisocyanate-induced); CESC cis rs6032067 0.777 rs2868237 chr20:43794189 C/T cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs3784262 0.904 rs12901462 chr15:58316487 A/G cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.05 -0.3 8.08e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg06481639 chr22:41940642 POLR3H 0.64 6.52 0.37 3.61e-10 Vitiligo; CESC cis rs7772486 0.790 rs80050589 chr6:146230454 T/C cg05347473 chr6:146136440 FBXO30 -0.57 -7.31 -0.41 3.07e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs7911712 0.565 rs2477529 chr10:45250582 C/G cg12743970 chr17:64536520 PRKCA -0.63 -6.02 -0.35 5.68e-9 Emphysema-related traits; CESC cis rs10751667 0.666 rs7395823 chr11:942701 T/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.44 -0.32 1.23e-7 Alzheimer's disease (late onset); CESC cis rs68170813 0.559 rs77829121 chr7:106968470 A/G cg02696742 chr7:106810147 HBP1 -0.54 -5.17 -0.3 4.64e-7 Coronary artery disease; CESC cis rs9916302 0.706 rs7503081 chr17:37482673 A/G cg07936489 chr17:37558343 FBXL20 0.94 10.63 0.55 3.23e-22 Glomerular filtration rate (creatinine); CESC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg27266027 chr21:40555129 PSMG1 0.4 5.13 0.3 5.63e-7 Cognitive function; CESC cis rs6502050 0.835 rs34199331 chr17:80134487 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.42 -0.37 6.39e-10 Life satisfaction; CESC cis rs6967414 0.786 rs9639026 chr7:6746736 A/G cg00387323 chr7:6746715 ZNF12 0.69 6.89 0.39 4.06e-11 Hematocrit;Hemoglobin concentration; CESC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg04248312 chr19:17393744 ANKLE1 -0.92 -14.73 -0.67 2.83e-36 Systemic lupus erythematosus; CESC cis rs3020736 0.500 rs7364293 chr22:42506370 C/T cg04733989 chr22:42467013 NAGA -0.83 -12.49 -0.61 1.9e-28 Autism spectrum disorder or schizophrenia; CESC cis rs17401966 0.838 rs61775887 chr1:10284733 T/C cg15208524 chr1:10270712 KIF1B 0.42 5.45 0.32 1.14e-7 Hepatocellular carcinoma; CESC cis rs941873 0.868 rs2233718 chr10:81108956 A/G cg09469691 chr10:81107165 PPIF 0.54 7.29 0.41 3.65e-12 Height; CESC cis rs6088580 0.634 rs6087587 chr20:33058628 G/T cg06115741 chr20:33292138 TP53INP2 0.47 6.09 0.35 4.03e-9 Glomerular filtration rate (creatinine); CESC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg24101359 chr6:42928495 GNMT -0.45 -6.79 -0.38 7.55e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs72634258 0.945 rs12757968 chr1:8106201 A/G cg00042356 chr1:8021962 PARK7 0.8 7.14 0.4 9.2e-12 Inflammatory bowel disease; CESC cis rs8180040 0.620 rs7373821 chr3:47080127 A/C cg27129171 chr3:47204927 SETD2 0.66 9.82 0.52 1.32e-19 Colorectal cancer; CESC cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.29 -5.22 -0.31 3.69e-7 Electroencephalogram traits; CESC cis rs7786808 0.649 rs6459879 chr7:158211792 C/G cg09998033 chr7:158218633 PTPRN2 -0.37 -5.41 -0.32 1.43e-7 Obesity-related traits; CESC cis rs9322193 0.651 rs9322188 chr6:149909491 A/G cg07701084 chr6:150067640 NUP43 -0.41 -5.65 -0.33 4.23e-8 Lung cancer; CESC cis rs921968 0.565 rs608047 chr2:219615910 A/C cg02176678 chr2:219576539 TTLL4 0.39 6.87 0.39 4.68e-11 Mean corpuscular hemoglobin concentration; CESC cis rs11122272 0.735 rs2486730 chr1:231534987 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs2180341 1.000 rs9285460 chr6:127640190 A/G cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6.31e-39 Breast cancer; CESC cis rs634534 0.562 rs661335 chr11:65754061 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 6.02 0.35 5.67e-9 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs9549367 0.713 rs4907599 chr13:113861441 C/T cg00898013 chr13:113819073 PROZ 0.44 6.61 0.38 2.15e-10 Platelet distribution width; CESC cis rs7762018 1.000 rs41265383 chr6:170068025 T/C cg13891659 chr6:170190454 C6orf122;C6orf208 0.52 5.34 0.31 2e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs870825 0.616 rs7667449 chr4:185641711 T/C cg04058563 chr4:185651563 MLF1IP 0.65 7.14 0.4 9.06e-12 Blood protein levels; CESC cis rs7267979 0.966 rs3002698 chr20:25303379 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -16.78 -0.72 1.5e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs738322 1.000 rs133009 chr22:38569653 G/C cg25457927 chr22:38595422 NA -0.3 -5.51 -0.32 8.66e-8 Cutaneous nevi; CESC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11668638 chr6:42952412 PPP2R5D 0.46 6.19 0.36 2.26e-9 Systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19906694 chr5:60629770 ZSWIM6 -0.47 -6.19 -0.36 2.34e-9 Fibrinogen levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25682936 chr1:38455768 SF3A3 -0.44 -6.18 -0.35 2.38e-9 Gambling; CESC cis rs6964587 0.869 rs2013334 chr7:91549657 G/A cg17063962 chr7:91808500 NA -0.53 -7.09 -0.4 1.21e-11 Breast cancer; CESC cis rs6088590 1.000 rs6088595 chr20:33358499 T/A cg06115741 chr20:33292138 TP53INP2 0.59 7.02 0.4 1.84e-11 Coronary artery disease; CESC cis rs7246657 0.943 rs10415024 chr19:37814724 A/G cg23950597 chr19:37808831 NA -0.6 -6.08 -0.35 4.27e-9 Coronary artery calcification; CESC cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg14393609 chr7:65229607 NA 0.43 5.46 0.32 1.12e-7 Aortic root size; CESC cis rs11864453 0.612 rs12708925 chr16:72122706 A/T cg16558253 chr16:72132732 DHX38 -0.54 -8.41 -0.46 2.65e-15 Fibrinogen levels; CESC cis rs10885582 0.754 rs10749167 chr10:116300041 G/C cg17056676 chr10:116301354 ABLIM1 -0.29 -5.33 -0.31 2.14e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg04025307 chr7:1156635 C7orf50 0.53 8.92 0.48 8.11e-17 Longevity;Endometriosis; CESC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg20271620 chr17:80763330 TBCD 0.43 5.71 0.33 2.98e-8 Breast cancer; CESC cis rs5753037 0.585 rs5752962 chr22:30188245 A/C cg01021169 chr22:30184971 ASCC2 -0.56 -8.59 -0.47 7.73e-16 Type 1 diabetes; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg17878204 chr1:145611075 RNF115;POLR3C 0.48 6.13 0.35 3.23e-9 Attention deficit hyperactivity disorder; CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg09177884 chr7:1199841 ZFAND2A -0.66 -8.77 -0.47 2.21e-16 Longevity;Endometriosis; CESC cis rs2637266 0.703 rs846646 chr10:78515883 C/T cg18941641 chr10:78392320 NA 0.38 7.5 0.42 9.82e-13 Pulmonary function; CESC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg12311346 chr5:56204834 C5orf35 0.69 8.7 0.47 3.65e-16 Initial pursuit acceleration; CESC cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.15e-15 Colonoscopy-negative controls vs population controls; CESC cis rs11723261 0.582 rs11248005 chr4:166615 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.44 5.57 0.32 6.39e-8 Immune response to smallpox vaccine (IL-6); CESC cis rs660498 0.516 rs638324 chr10:27730261 A/C cg08398567 chr10:27609333 NA 0.36 5.13 0.3 5.71e-7 Asthma (childhood onset); CESC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.19e-10 Life satisfaction; CESC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg12311346 chr5:56204834 C5orf35 -0.42 -5.27 -0.31 2.79e-7 Coronary artery disease; CESC cis rs113835537 0.935 rs79106199 chr11:66420518 T/C cg22134325 chr11:66188745 NPAS4 0.51 5.84 0.34 1.55e-8 Airway imaging phenotypes; CESC cis rs4243830 1.000 rs12401795 chr1:6594773 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.78 6.22 0.36 1.95e-9 Body mass index; CESC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg25036284 chr2:26402008 FAM59B -0.89 -10.85 -0.55 6.05e-23 Gut microbiome composition (summer); CESC cis rs929354 0.739 rs12533082 chr7:157014172 T/A cg05182265 chr7:156933206 UBE3C -0.5 -7.39 -0.41 1.88e-12 Body mass index; CESC cis rs2073300 0.609 rs3746733 chr20:23349749 C/T cg16736954 chr20:23401023 NAPB 0.72 5.54 0.32 7.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21646326 chr4:77227811 STBD1 0.62 7.29 0.41 3.57e-12 Gut microbiome composition (summer); CESC cis rs8060686 0.920 rs73591955 chr16:67782568 G/T cg26727032 chr16:67993705 SLC12A4 -0.57 -6.22 -0.36 1.92e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs17685 0.712 rs4552844 chr7:75718095 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 12.47 0.61 2.13e-28 Coffee consumption;Coffee consumption (cups per day); CESC trans rs11098499 0.754 rs10212714 chr4:120254302 T/C cg25214090 chr10:38739885 LOC399744 0.64 8.81 0.48 1.68e-16 Corneal astigmatism; CESC cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg20307385 chr11:47447363 PSMC3 0.56 6.65 0.38 1.65e-10 Subjective well-being; CESC cis rs6582630 0.519 rs11182021 chr12:38443709 A/T cg26384229 chr12:38710491 ALG10B -0.64 -9.48 -0.5 1.5e-18 Drug-induced liver injury (flucloxacillin); CESC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg22467129 chr15:76604101 ETFA -0.38 -5.75 -0.33 2.43e-8 Blood metabolite levels; CESC cis rs4803468 1.000 rs2231940 chr19:41944237 T/C cg09537434 chr19:41945824 ATP5SL 1.12 21.48 0.8 5.84e-60 Height; CESC cis rs7568458 0.709 rs11895401 chr2:85753847 C/T cg02493740 chr2:85810744 VAMP5 -0.57 -8.48 -0.46 1.57e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs7072216 0.763 rs7911036 chr10:100167015 A/T cg26618903 chr10:100175079 PYROXD2 -0.36 -5.49 -0.32 9.42e-8 Metabolite levels; CESC cis rs2795502 0.873 rs1891324 chr10:43399581 A/G cg27426351 chr10:43362370 NA 0.49 5.97 0.34 7.63e-9 Blood protein levels; CESC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg08859206 chr1:53392774 SCP2 -0.59 -8.23 -0.45 8.65e-15 Monocyte count; CESC cis rs4253772 0.637 rs6008339 chr22:46650846 C/T cg24881330 chr22:46731750 TRMU 0.89 10.09 0.53 1.86e-20 LDL cholesterol;Cholesterol, total; CESC cis rs1008375 0.931 rs10008337 chr4:17593849 G/C cg16339924 chr4:17578868 LAP3 0.73 9.5 0.5 1.31e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs870825 0.860 rs72703527 chr4:185605997 C/A cg04058563 chr4:185651563 MLF1IP 0.54 5.24 0.31 3.27e-7 Blood protein levels; CESC cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg23711669 chr6:146136114 FBXO30 1.02 16.0 0.7 8.93e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.693 rs8080061 chr17:17776389 C/T cg04398451 chr17:18023971 MYO15A 0.64 9.38 0.5 3.08e-18 Total body bone mineral density; CESC cis rs13130787 0.606 rs1370821 chr4:94943383 C/T cg11021082 chr4:95130006 SMARCAD1 0.45 6.26 0.36 1.55e-9 Colorectal cancer; CESC cis rs3768617 0.510 rs2296293 chr1:183095477 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs11677416 1.000 rs34015482 chr2:113525745 A/G cg27083787 chr2:113543245 IL1A 0.58 7.33 0.41 2.81e-12 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg11494091 chr17:61959527 GH2 0.73 12.55 0.61 1.13e-28 Prudent dietary pattern; CESC cis rs10242455 0.702 rs115279860 chr7:98994492 C/T cg25640893 chr7:99214727 ZNF498 1.07 6.42 0.37 6.22e-10 Blood metabolite levels; CESC cis rs2014572 0.967 rs11667407 chr19:57763122 C/T cg24459738 chr19:57751996 ZNF805 -0.53 -7.54 -0.42 7.48e-13 Hyperactive-impulsive symptoms; CESC cis rs9467711 0.606 rs2073530 chr6:26375243 T/C cg12826209 chr6:26865740 GUSBL1 0.65 5.35 0.31 1.88e-7 Autism spectrum disorder or schizophrenia; CESC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg12667521 chr19:29218732 NA 0.48 6.28 0.36 1.37e-9 Methadone dose in opioid dependence; CESC cis rs561341 0.740 rs11080174 chr17:30208521 C/A cg13647721 chr17:30228624 UTP6 -0.76 -9.3 -0.5 5.52e-18 Hip circumference adjusted for BMI; CESC cis rs61332075 0.518 rs56171132 chr2:239378856 C/T cg18131467 chr2:239335373 ASB1 -0.74 -6.11 -0.35 3.58e-9 Lung function (FEV1/FVC); CESC cis rs1395 0.778 rs1978881 chr2:27400850 C/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 5.5 0.32 8.91e-8 Blood metabolite levels; CESC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg19592336 chr6:28129416 ZNF389 0.47 6.44 0.37 5.49e-10 Parkinson's disease; CESC cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3105593 0.635 rs3131567 chr15:50757930 A/T cg05456662 chr15:50716270 USP8 0.41 5.53 0.32 7.86e-8 QT interval; CESC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.69 0.33 3.44e-8 Bipolar disorder; CESC cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg11764359 chr7:65958608 NA 0.65 8.21 0.45 9.47e-15 Aortic root size; CESC cis rs7100689 0.646 rs1340384 chr10:82088702 T/A cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 4.91e-14 Post bronchodilator FEV1; CESC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.27 0.41 4.02e-12 Bipolar disorder; CESC cis rs7250872 0.647 rs2304612 chr19:1817866 A/G cg02747822 chr19:1826707 REXO1 -0.37 -5.15 -0.3 5.13e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15900544 chr1:153606818 C1orf77;S100A13 0.58 6.09 0.35 3.94e-9 Gut microbiome composition (summer); CESC cis rs3892630 0.588 rs7248798 chr19:33303684 G/T cg13157960 chr19:33183277 NUDT19 0.55 5.59 0.32 5.67e-8 Red blood cell traits; CESC cis rs2439831 0.867 rs12324572 chr15:43636200 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.84 12.56 0.61 1.02e-28 Lung cancer in ever smokers; CESC cis rs57506017 0.628 rs2302635 chr7:12270625 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.17 0.3 4.56e-7 Neuroticism; CESC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Tonsillectomy; CESC cis rs8014204 1.000 rs8014204 chr14:75322794 A/G cg08847533 chr14:75593920 NEK9 0.48 6.08 0.35 4.26e-9 Caffeine consumption; CESC cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg01475377 chr6:109611718 NA -0.41 -6.16 -0.35 2.7e-9 Reticulocyte fraction of red cells; CESC cis rs12973672 0.812 rs12979058 chr19:35750684 G/A cg12095397 chr19:35769544 USF2 0.5 6.0 0.35 6.44e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs28829049 0.597 rs12745238 chr1:19393710 C/T cg13387374 chr1:19411106 UBR4 0.44 5.62 0.33 4.73e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs829880 0.558 rs249821 chr12:98897811 T/C cg25150519 chr12:98850993 NA 0.51 5.97 0.34 7.65e-9 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg19163074 chr7:65112434 INTS4L2 0.47 5.05 0.3 8.31e-7 Aortic root size; CESC cis rs5758659 1.000 rs5751255 chr22:42648408 C/T cg04733989 chr22:42467013 NAGA 0.41 5.6 0.33 5.42e-8 Cognitive function; CESC cis rs12824058 0.798 rs7968728 chr12:130804696 T/A cg23887609 chr12:130822674 PIWIL1 0.43 5.3 0.31 2.45e-7 Menopause (age at onset); CESC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg00310523 chr12:86230176 RASSF9 -0.35 -5.49 -0.32 9.21e-8 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19319069 chr7:129593010 UBE2H -0.6 -7.05 -0.4 1.57e-11 Gut microbiome composition (summer); CESC cis rs12477438 0.520 rs13798 chr2:99813614 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 15.95 0.7 1.34e-40 Chronic sinus infection; CESC cis rs8017423 0.967 rs7142513 chr14:90705182 T/C cg14092571 chr14:90743983 NA -0.55 -8.08 -0.44 2.37e-14 Mortality in heart failure; CESC cis rs2404618 0.624 rs7012381 chr8:1475357 C/T cg13402656 chr8:1511478 DLGAP2 -0.48 -6.69 -0.38 1.3100000000000001e-10 Lung cancer; CESC cis rs858239 0.600 rs10256524 chr7:23144947 T/C cg23682824 chr7:23144976 KLHL7 0.54 7.7 0.43 2.72e-13 Cerebrospinal fluid biomarker levels; CESC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg22800045 chr5:56110881 MAP3K1 0.57 7.53 0.42 8.21e-13 Initial pursuit acceleration; CESC cis rs796364 0.662 rs11687313 chr2:201146399 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.71 -5.11 -0.3 6.16e-7 Schizophrenia; CESC cis rs7605827 0.930 rs13015492 chr2:15505716 G/A cg19274914 chr2:15703543 NA 0.32 5.76 0.33 2.33e-8 Educational attainment (years of education); CESC cis rs73206853 0.841 rs73191828 chr12:110946121 G/A cg12870014 chr12:110450643 ANKRD13A 0.63 5.22 0.31 3.56e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7267979 1.000 rs6050617 chr20:25421648 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 3e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs1499614 1.000 rs2707828 chr7:66171377 G/A cg13147721 chr7:65941812 NA -0.94 -8.9 -0.48 9.08e-17 Gout; CESC cis rs61931739 0.534 rs10844816 chr12:34248533 C/A cg19457237 chr12:34500585 NA -0.38 -5.34 -0.31 2.02e-7 Morning vs. evening chronotype; CESC cis rs1707322 0.721 rs11211149 chr1:46112218 T/C cg05343316 chr1:45956843 TESK2 0.5 6.18 0.35 2.46e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg02711726 chr17:80685570 FN3KRP -0.43 -5.72 -0.33 2.8e-8 Glycated hemoglobin levels; CESC cis rs73206853 0.563 rs34378671 chr12:111163204 C/T cg12870014 chr12:110450643 ANKRD13A 0.64 5.66 0.33 3.91e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs12310956 0.532 rs1852226 chr12:33962940 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.68 0.38 1.37e-10 Morning vs. evening chronotype; CESC cis rs10489525 0.599 rs17033129 chr1:115611539 C/T cg12756093 chr1:115239321 AMPD1 -0.45 -5.59 -0.32 5.56e-8 Autism; CESC cis rs4955124 0.818 rs4955220 chr3:32043207 A/G cg05935571 chr3:32023257 ZNF860;OSBPL10 0.66 5.29 0.31 2.5e-7 Schizophrenia; CESC cis rs2288912 0.807 rs10423208 chr19:45453656 G/A cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.58e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs10129255 0.500 rs6576225 chr14:107186359 G/C cg23076370 chr14:107095027 NA -0.65 -9.67 -0.51 3.98e-19 Kawasaki disease; CESC cis rs1008375 1.000 rs4698651 chr4:17694223 A/G cg16339924 chr4:17578868 LAP3 0.58 7.08 0.4 1.33e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.61 5.64 0.33 4.37e-8 Breast cancer; CESC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg21226059 chr5:178986404 RUFY1 0.52 8.09 0.44 2.18e-14 Lung cancer; CESC trans rs2797160 0.651 rs1268067 chr6:126036621 T/C cg05039488 chr6:79577232 IRAK1BP1 0.48 6.44 0.37 5.59e-10 Endometrial cancer; CESC cis rs6598955 0.640 rs6667826 chr1:26531408 T/C cg00852783 chr1:26633632 UBXN11 0.4 5.85 0.34 1.41e-8 Obesity-related traits; CESC cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs7584330 0.657 rs7599658 chr2:238352898 A/C cg14458575 chr2:238380390 NA -0.66 -9.26 -0.49 7.41e-18 Prostate cancer; CESC cis rs10504229 0.679 rs16921606 chr8:58034477 A/C cg24829409 chr8:58192753 C8orf71 -0.42 -5.53 -0.32 7.58e-8 Developmental language disorder (linguistic errors); CESC cis rs832540 0.519 rs10940518 chr5:56270794 C/T cg14703610 chr5:56206110 C5orf35 0.53 6.86 0.39 4.71e-11 Coronary artery disease; CESC cis rs6732160 0.588 rs2043101 chr2:73374050 A/G cg01422370 chr2:73384389 NA 0.58 9.54 0.51 9.53e-19 Intelligence (multi-trait analysis); CESC cis rs9430161 0.579 rs7542164 chr1:11040223 G/A cg02454025 chr1:11042201 C1orf127 0.87 13.72 0.64 9.82e-33 Ewing sarcoma; CESC trans rs10028773 0.700 rs35653026 chr4:120248378 A/G cg25214090 chr10:38739885 LOC399744 0.62 8.36 0.46 3.48e-15 Educational attainment; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09419297 chr15:77712428 HMG20A -0.45 -6.09 -0.35 3.97e-9 Gut microbiota (bacterial taxa); CESC cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg23649088 chr2:200775458 C2orf69 0.71 8.81 0.48 1.64e-16 Osteoporosis; CESC cis rs4253772 0.575 rs9615364 chr22:46797503 G/A cg18190219 chr22:46762943 CELSR1 -0.6 -6.22 -0.36 1.97e-9 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23323137 chr6:42532021 UBR2 0.57 6.46 0.37 4.94e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.36 0.6 5.3e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11098499 0.863 rs11736416 chr4:120431661 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.54e-19 Corneal astigmatism; CESC cis rs35110281 0.805 rs2838317 chr21:44991791 A/C cg21573476 chr21:45109991 RRP1B -0.43 -5.96 -0.34 8.16e-9 Mean corpuscular volume; CESC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg12463550 chr7:65579703 CRCP 0.57 7.2 0.4 6.12e-12 Aortic root size; CESC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg18538332 chr22:24372958 LOC391322 -0.74 -10.81 -0.55 8.55e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6499129 0.867 rs1862689 chr16:67419152 C/T cg26727032 chr16:67993705 SLC12A4 -0.5 -5.62 -0.33 4.95e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs6831352 0.918 rs3919370 chr4:100064326 A/T cg13256891 chr4:100009986 ADH5 -0.73 -7.79 -0.43 1.52e-13 Alcohol dependence; CESC cis rs796364 0.806 rs79725795 chr2:201083534 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.12 -0.35 3.32e-9 Schizophrenia; CESC cis rs9911578 0.935 rs9911753 chr17:56983174 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.4 5.31 0.31 2.36e-7 Intelligence (multi-trait analysis); CESC cis rs9916302 0.706 rs12937013 chr17:37665571 G/A cg07936489 chr17:37558343 FBXL20 -0.91 -9.97 -0.52 4.37e-20 Glomerular filtration rate (creatinine); CESC cis rs17666538 1.000 rs59631161 chr8:587808 G/T cg13264159 chr8:625131 ERICH1 0.74 5.14 0.3 5.34e-7 IgG glycosylation; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12105361 chr19:10216875 PPAN-P2RY11;SNORD105;PPAN -0.47 -6.14 -0.35 2.97e-9 Asthma; CESC trans rs7618501 0.699 rs2777888 chr3:49898000 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.49 6.8 0.39 6.79e-11 Intelligence (multi-trait analysis); CESC cis rs12220238 1.000 rs10824078 chr10:75892120 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.23 0.36 1.87e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2898681 0.561 rs2200225 chr4:53738411 A/G cg00791764 chr4:53727839 RASL11B 0.45 5.45 0.32 1.13e-7 Optic nerve measurement (cup area); CESC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg10691866 chr7:65817282 TPST1 -0.33 -5.39 -0.31 1.58e-7 Aortic root size; CESC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg21280719 chr6:42927975 GNMT -0.27 -6.08 -0.35 4.09e-9 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7020830 0.858 rs67036212 chr9:37133538 A/G cg14294708 chr9:37120828 ZCCHC7 1.25 23.68 0.82 2.39e-67 Schizophrenia; CESC trans rs1908814 0.510 rs57655799 chr8:11782417 A/C cg15556689 chr8:8085844 FLJ10661 0.51 6.21 0.36 1.99e-9 Neuroticism; CESC cis rs6963495 0.818 rs73190167 chr7:105160418 A/G cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs4466137 1.000 rs4466137 chr5:82985739 A/C cg16102102 chr5:83017553 HAPLN1 -0.42 -6.36 -0.36 8.92e-10 Prostate cancer; CESC cis rs4588572 0.615 rs4143070 chr5:77769094 G/C cg11547950 chr5:77652471 NA -0.4 -5.47 -0.32 1.07e-7 Triglycerides; CESC cis rs739401 0.611 rs494427 chr11:3048140 A/G cg08508325 chr11:3079039 CARS -0.51 -10.01 -0.52 3.22e-20 Longevity; CESC cis rs9443189 1.000 rs6905047 chr6:76498109 C/T cg01950844 chr6:76311363 SENP6 0.62 5.97 0.34 7.42e-9 Prostate cancer; CESC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg16743903 chr16:89593216 SPG7 -0.49 -6.5 -0.37 3.95e-10 Multiple myeloma (IgH translocation); CESC cis rs644799 1.000 rs1944074 chr11:95511445 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.55 0.51 8.96e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2294693 0.947 rs6924722 chr6:41002195 C/T cg14418226 chr6:40996092 UNC5CL -0.45 -5.81 -0.34 1.75e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.51 5.75 0.33 2.42e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg03351412 chr1:154909251 PMVK 0.6 7.73 0.43 2.26e-13 Prostate cancer; CESC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg05617483 chr15:76483344 C15orf27 0.4 5.34 0.31 2.01e-7 Blood metabolite levels; CESC cis rs9487051 0.768 rs442405 chr6:109526980 T/G cg01475377 chr6:109611718 NA -0.44 -6.66 -0.38 1.56e-10 Reticulocyte fraction of red cells; CESC cis rs7107174 1.000 rs10899465 chr11:78013588 G/A cg02023728 chr11:77925099 USP35 0.49 6.42 0.37 6.18e-10 Testicular germ cell tumor; CESC cis rs11122272 0.668 rs2808616 chr1:231554993 C/G cg06096015 chr1:231504339 EGLN1 -0.39 -5.65 -0.33 4.21e-8 Hemoglobin concentration; CESC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7851660 0.809 rs3808893 chr9:100663745 C/T cg13688889 chr9:100608707 NA -0.62 -8.87 -0.48 1.11e-16 Strep throat; CESC cis rs1348850 0.918 rs12463893 chr2:178448559 G/T cg23306229 chr2:178417860 TTC30B 0.55 7.17 0.4 7.52e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4660306 0.961 rs4660867 chr1:45986484 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.72 -0.43 2.33e-13 Homocysteine levels; CESC cis rs3087591 0.960 rs1013947 chr17:29530362 C/T cg24425628 chr17:29625626 OMG;NF1 0.43 5.35 0.31 1.9e-7 Hip circumference; CESC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -9.22 -0.49 9.72e-18 Developmental language disorder (linguistic errors); CESC cis rs6499255 0.951 rs56282083 chr16:69825728 C/T cg15192750 chr16:69999425 NA 0.43 5.35 0.31 1.91e-7 IgE levels; CESC cis rs6087771 0.650 rs6060395 chr20:30219823 G/C cg13852791 chr20:30311386 BCL2L1 0.67 7.84 0.43 1.11e-13 Subcortical brain region volumes;Putamen volume; CESC trans rs17685 0.753 rs1639609 chr7:75683581 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 12.38 0.61 4.45e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg05535760 chr7:792225 HEATR2 0.87 10.97 0.56 2.5e-23 Cerebrospinal P-tau181p levels; CESC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg17971929 chr21:40555470 PSMG1 -0.87 -12.61 -0.61 6.96e-29 Cognitive function; CESC cis rs453301 0.507 rs2929306 chr8:9084909 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.0 -0.39 2.15e-11 Joint mobility (Beighton score); CESC cis rs4268898 1.000 rs6707781 chr2:24441883 T/G cg06627628 chr2:24431161 ITSN2 0.66 8.08 0.44 2.26e-14 Asthma; CESC cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg12927641 chr6:109611667 NA -0.41 -6.13 -0.35 3.09e-9 Reticulocyte fraction of red cells; CESC cis rs9388451 0.587 rs1739385 chr6:126099939 G/A cg05901451 chr6:126070800 HEY2 -0.57 -8.24 -0.45 7.88e-15 Brugada syndrome; CESC cis rs4835473 0.669 rs75704080 chr4:144700219 A/T cg25736465 chr4:144833511 NA -0.33 -5.18 -0.3 4.42e-7 Immature fraction of reticulocytes; CESC cis rs7607369 0.580 rs7594289 chr2:219652286 A/G cg02176678 chr2:219576539 TTLL4 -0.49 -8.59 -0.47 7.42e-16 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs12477438 0.798 rs6705821 chr2:99602832 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg05347473 chr6:146136440 FBXO30 -0.56 -6.87 -0.39 4.53e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg18252515 chr7:66147081 NA -0.47 -6.41 -0.37 6.57e-10 Aortic root size; CESC trans rs1219515 0.614 rs1696821 chr10:123463056 G/A cg09033641 chr16:89436838 ANKRD11 0.54 6.13 0.35 3.21e-9 Magnesium levels; CESC cis rs6087990 0.965 rs2424899 chr20:31343543 A/C cg13636640 chr20:31349939 DNMT3B 0.9 16.32 0.71 6.41e-42 Ulcerative colitis; CESC cis rs698833 0.828 rs4952710 chr2:44524575 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.83 0.34 1.63e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1707322 0.721 rs56255771 chr1:46224319 C/T cg05343316 chr1:45956843 TESK2 0.47 6.02 0.35 5.8e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs9291683 0.530 rs13115193 chr4:9982191 C/T cg02734326 chr4:10020555 SLC2A9 0.46 6.9 0.39 3.73e-11 Bone mineral density; CESC cis rs9916302 0.706 rs2338799 chr17:37513941 G/A cg07936489 chr17:37558343 FBXL20 0.89 9.69 0.51 3.45e-19 Glomerular filtration rate (creatinine); CESC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.23 -0.36 1.8e-9 Total body bone mineral density; CESC cis rs9581857 0.579 rs3759434 chr13:27997700 A/C cg01674679 chr13:27998804 GTF3A -0.63 -6.3 -0.36 1.26e-9 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.63 0.51 5.12e-19 Platelet count; CESC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg08704611 chr17:80376099 HEXDC;C17orf101 -0.43 -5.06 -0.3 7.89e-7 Breast cancer; CESC cis rs11676348 0.811 rs13027120 chr2:219020914 C/T cg00012203 chr2:219082015 ARPC2 0.54 6.89 0.39 4.03e-11 Ulcerative colitis; CESC cis rs524281 0.861 rs485857 chr11:65959519 A/G cg14036092 chr11:66035641 RAB1B -0.49 -5.5 -0.32 9.06e-8 Electroencephalogram traits; CESC cis rs34779708 0.931 rs4934710 chr10:35350416 T/C cg04310649 chr10:35416472 CREM -0.49 -5.87 -0.34 1.31e-8 Inflammatory bowel disease;Crohn's disease; CESC trans rs61931739 0.534 rs11053075 chr12:34207009 A/G cg26384229 chr12:38710491 ALG10B -0.63 -9.08 -0.49 2.55e-17 Morning vs. evening chronotype; CESC cis rs12541635 0.677 rs12546875 chr8:107012915 C/T cg10147462 chr8:107024639 NA 0.48 7.12 0.4 1.03e-11 Age of smoking initiation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12833323 chr8:145180747 NA -0.55 -6.06 -0.35 4.66e-9 Gut microbiome composition (summer); CESC cis rs2637266 0.905 rs3923669 chr10:78375047 T/C cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC cis rs8114671 0.869 rs2145559 chr20:33651725 G/A cg07148914 chr20:33460835 GGT7 -0.41 -5.24 -0.31 3.28e-7 Height; CESC cis rs703842 1.000 rs10783847 chr12:58196447 G/A cg00599273 chr12:58146742 CDK4 0.33 5.04 0.3 8.52e-7 Multiple sclerosis; CESC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg01939980 chr4:1354348 KIAA1530 0.41 5.53 0.32 7.61e-8 Longevity; CESC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg00149659 chr3:10157352 C3orf10 1.01 11.49 0.58 4.52e-25 Alzheimer's disease; CESC cis rs8005677 1.000 rs1043209 chr14:23373986 A/G cg25600027 chr14:23388339 RBM23 0.42 5.11 0.3 6.24e-7 Cognitive ability (multi-trait analysis); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg17001531 chr1:16825540 NA -0.43 -6.12 -0.35 3.39e-9 Recombination measurement; CESC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg06481639 chr22:41940642 POLR3H -0.67 -7.01 -0.4 1.95e-11 Vitiligo; CESC cis rs938554 0.784 rs10939638 chr4:9977675 T/A cg00071950 chr4:10020882 SLC2A9 0.48 5.68 0.33 3.49e-8 Blood metabolite levels; CESC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg00784671 chr22:46762841 CELSR1 -0.52 -5.49 -0.32 9.24e-8 LDL cholesterol;Cholesterol, total; CESC cis rs3540 0.533 rs12916560 chr15:91056259 A/C cg22089800 chr15:90895588 ZNF774 -0.61 -8.11 -0.45 1.93e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg25405998 chr7:65216604 CCT6P1 0.46 5.21 0.3 3.87e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14849479 chr5:60039648 NA 0.41 6.1 0.35 3.83e-9 Fibrinogen levels; CESC cis rs7178572 0.568 rs11857294 chr15:77596725 C/T cg22256960 chr15:77711686 NA -0.53 -6.6 -0.38 2.26e-10 Type 2 diabetes; CESC trans rs9929218 1.000 rs12930371 chr16:68802936 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.47 0.46 1.75e-15 Colorectal cancer; CESC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg07157834 chr1:205819609 PM20D1 0.71 11.02 0.56 1.73e-23 Menarche (age at onset); CESC cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg22903471 chr2:27725779 GCKR -0.55 -7.72 -0.43 2.43e-13 Total body bone mineral density; CESC cis rs6541297 0.941 rs2144299 chr1:230280366 A/G cg05784532 chr1:230284198 GALNT2 0.47 5.38 0.31 1.63e-7 Coronary artery disease; CESC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg07395648 chr5:131743802 NA 0.44 5.48 0.32 1.01e-7 Breast cancer;Mosquito bite size; CESC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13986503 chr11:126152983 TIRAP 0.58 7.04 0.4 1.64e-11 Gut microbiome composition (summer); CESC trans rs6794880 0.943 rs1482385 chr3:84459213 G/T cg03554283 chr8:76319451 NA -0.56 -6.08 -0.35 4.27e-9 Body mass index (joint analysis main effects and smoking interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg24675658 chr1:53192096 ZYG11B 0.56 7.04 0.4 1.63e-11 Monocyte count; CESC cis rs7560272 0.501 rs6750494 chr2:73946496 G/A cg20560298 chr2:73613845 ALMS1 0.41 5.61 0.33 5.1e-8 Schizophrenia; CESC cis rs7640424 0.628 rs7628325 chr3:107816314 G/A cg09227934 chr3:107805635 CD47 -0.47 -5.77 -0.33 2.24e-8 Body mass index; CESC cis rs4820294 1.000 rs78974622 chr22:38059925 A/C cg21798802 chr22:38057573 PDXP 0.46 7.88 0.44 8.53e-14 Fat distribution (HIV); CESC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg06873352 chr17:61820015 STRADA 0.73 12.83 0.62 1.19e-29 Prudent dietary pattern; CESC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg22535103 chr8:58192502 C8orf71 -0.94 -9.92 -0.52 6.46e-20 Developmental language disorder (linguistic errors); CESC cis rs10791097 0.678 rs10894272 chr11:130731081 A/G cg12179176 chr11:130786555 SNX19 0.55 8.38 0.46 3.14e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs72781680 0.752 rs56152044 chr2:23927680 A/G cg20701182 chr2:24300061 SF3B14 0.81 7.13 0.4 9.6e-12 Lymphocyte counts; CESC cis rs6963495 0.585 rs1706923 chr7:105221097 A/G cg13798780 chr7:105162888 PUS7 0.54 6.76 0.38 8.58e-11 Bipolar disorder (body mass index interaction); CESC cis rs8017423 0.967 rs61989980 chr14:90727635 C/T cg14092571 chr14:90743983 NA -0.55 -8.17 -0.45 1.24e-14 Mortality in heart failure; CESC cis rs7520050 0.966 rs7556615 chr1:46461369 G/A cg03146154 chr1:46216737 IPP -0.48 -6.16 -0.35 2.71e-9 Red blood cell count;Reticulocyte count; CESC cis rs4953076 0.573 rs13008237 chr2:44404902 A/G cg04920474 chr2:44395004 PPM1B 0.55 7.07 0.4 1.37e-11 Height; CESC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg17372223 chr3:52568218 NT5DC2 0.43 6.34 0.36 1e-9 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08717488 chr1:205238158 TMCC2 -0.61 -6.75 -0.38 9.17e-11 Gut microbiome composition (summer); CESC cis rs5758659 0.904 rs134877 chr22:42662371 C/T cg04733989 chr22:42467013 NAGA 0.42 5.81 0.34 1.78e-8 Cognitive function; CESC cis rs977987 0.843 rs7499872 chr16:75426529 G/A cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.68e-8 Dupuytren's disease; CESC trans rs561341 1.000 rs546519 chr17:30297682 T/G cg27661571 chr11:113659931 NA -0.72 -7.36 -0.41 2.36e-12 Hip circumference adjusted for BMI; CESC cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 12.9 0.62 7.29e-30 Personality dimensions; CESC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg17971929 chr21:40555470 PSMG1 -0.55 -7.16 -0.4 8.14e-12 Menarche (age at onset); CESC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg21963583 chr11:68658836 MRPL21 0.43 6.33 0.36 1.03e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg05863683 chr7:1912471 MAD1L1 0.47 7.18 0.4 7e-12 Bipolar disorder and schizophrenia; CESC cis rs1707322 0.721 rs10890341 chr1:46147240 C/A cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6912958 0.512 rs910563 chr6:88058885 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.47 8.18 0.45 1.18e-14 Monocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03988675 chr1:14075428 PRDM2 -0.45 -6.2 -0.36 2.18e-9 Gut microbiota (bacterial taxa); CESC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg08704250 chr15:31115839 NA -0.63 -8.2 -0.45 1.06e-14 Huntington's disease progression; CESC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.27 0.31 2.88e-7 Tonsillectomy; CESC cis rs6545883 0.895 rs2442029 chr2:61679552 G/T cg15711740 chr2:61764176 XPO1 -0.4 -5.22 -0.31 3.61e-7 Tuberculosis; CESC cis rs9815354 0.812 rs73073230 chr3:42008263 G/A cg03022575 chr3:42003672 ULK4 0.69 6.24 0.36 1.72e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9479482 1.000 rs9478380 chr6:150354665 A/G cg03788504 chr6:150331562 NA 0.36 6.53 0.37 3.3e-10 Alopecia areata; CESC cis rs7503807 0.701 rs1485329 chr17:78643561 A/G cg09596252 chr17:78655493 RPTOR 0.42 5.77 0.33 2.19e-8 Obesity; CESC cis rs3741489 1.000 rs75810241 chr12:133365186 G/A cg01499426 chr12:133417423 CHFR 1.07 6.1 0.35 3.79e-9 Cognitive function; CESC cis rs4319547 0.695 rs10773167 chr12:122934001 C/T cg23029597 chr12:123009494 RSRC2 -0.48 -5.19 -0.3 4.24e-7 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16873973 chr7:5920535 OCM -0.42 -6.12 -0.35 3.43e-9 Gut microbiome composition (summer); CESC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg21782813 chr7:2030301 MAD1L1 0.49 7.05 0.4 1.52e-11 Bipolar disorder and schizophrenia; CESC cis rs11252926 0.507 rs4881199 chr10:428090 C/G cg16386425 chr10:429943 DIP2C -0.57 -7.5 -0.42 9.73e-13 Psychosis in Alzheimer's disease; CESC cis rs6032067 0.929 rs6032055 chr20:43833336 C/T cg10761708 chr20:43804764 PI3 0.52 6.3 0.36 1.27e-9 Blood protein levels; CESC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.82 -0.34 1.69e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9322193 0.962 rs2065664 chr6:150083621 A/G cg13206674 chr6:150067644 NUP43 0.41 5.64 0.33 4.37e-8 Lung cancer; CESC cis rs9916302 0.904 rs8077104 chr17:37530510 A/G cg00129232 chr17:37814104 STARD3 0.57 7.44 0.42 1.38e-12 Glomerular filtration rate (creatinine); CESC cis rs2204008 0.594 rs2711545 chr12:38061039 C/T cg26384229 chr12:38710491 ALG10B 0.44 5.96 0.34 7.93e-9 Bladder cancer; CESC cis rs4077515 0.967 rs10781500 chr9:139269338 A/G cg14169450 chr9:139327907 INPP5E -0.34 -5.03 -0.3 9.17e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs3093024 0.967 rs1571878 chr6:167540842 C/T cg07741184 chr6:167504864 NA -0.33 -5.56 -0.32 6.49e-8 Rheumatoid arthritis; CESC cis rs1065852 0.510 rs5751247 chr22:42633054 T/C cg00645731 chr22:42541494 CYP2D7P1 0.38 6.21 0.36 2.08e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg07677032 chr17:61819896 STRADA 0.46 6.21 0.36 2.06e-9 Prudent dietary pattern; CESC trans rs11098499 0.863 rs12508173 chr4:120318526 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.7 0.51 3.1400000000000002e-19 Corneal astigmatism; CESC cis rs1003719 0.762 rs2835590 chr21:38463406 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs72772090 0.539 rs11750464 chr5:96113031 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.59 5.11 0.3 6.29e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg03526776 chr6:41159608 TREML2 -0.39 -6.54 -0.37 3.18e-10 Alzheimer's disease (late onset); CESC cis rs17023223 0.537 rs12086686 chr1:119689084 T/A cg05756136 chr1:119680316 WARS2 -0.46 -5.58 -0.32 6.01e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.44 0.46 2.09e-15 Colonoscopy-negative controls vs population controls; CESC cis rs12530845 0.943 rs55889179 chr7:135331631 C/T cg23117316 chr7:135346802 PL-5283 -0.45 -5.58 -0.32 6.05e-8 Red blood cell traits; CESC cis rs12142240 0.698 rs1135460 chr1:46815970 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs854765 0.547 rs2955378 chr17:17930253 G/A cg09796270 chr17:17721594 SREBF1 0.38 5.3 0.31 2.5e-7 Total body bone mineral density; CESC cis rs10465746 0.935 rs942848 chr1:84427707 G/C cg10977910 chr1:84465055 TTLL7 0.46 6.18 0.35 2.45e-9 Obesity-related traits; CESC cis rs753778 0.667 rs10103731 chr8:142206068 C/T cg23750338 chr8:142222470 SLC45A4 0.36 5.14 0.3 5.35e-7 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs941873 0.835 rs4246944 chr10:81105684 C/T cg11057378 chr10:81107060 PPIF 0.32 5.12 0.3 5.94e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13063101 chr1:119914432 HAO2 0.51 6.26 0.36 1.58e-9 Gut microbiome composition (summer); CESC cis rs202629 1 rs202629 chr22:41849975 C/T cg06634786 chr22:41940651 POLR3H 0.59 6.39 0.37 7.33e-10 Cannabis dependence symptom count; CESC cis rs1008375 0.900 rs13144986 chr4:17675019 C/A cg27347728 chr4:17578864 LAP3 -0.48 -5.3 -0.31 2.49e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11785400 1.000 rs10108059 chr8:143750028 G/T cg24634471 chr8:143751801 JRK -0.47 -6.13 -0.35 3.26e-9 Schizophrenia; CESC cis rs7000551 0.725 rs2461489 chr8:22370253 G/A cg12081754 chr8:22256438 SLC39A14 0.45 6.02 0.35 5.74e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 7.41 0.41 1.7e-12 Melanoma; CESC cis rs9916302 0.904 rs6503519 chr17:37706578 A/G cg07936489 chr17:37558343 FBXL20 -0.8 -11.36 -0.57 1.25e-24 Glomerular filtration rate (creatinine); CESC cis rs11098499 0.863 rs3736115 chr4:120488703 A/G cg24375607 chr4:120327624 NA -0.45 -5.34 -0.31 2.05e-7 Corneal astigmatism; CESC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg06108461 chr20:60628389 TAF4 -0.92 -14.32 -0.66 7.92e-35 Body mass index; CESC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg27057461 chr7:158136379 PTPRN2 -0.33 -5.17 -0.3 4.6e-7 Calcium levels; CESC cis rs9300255 0.602 rs1716177 chr12:123655457 C/T cg00376283 chr12:123451042 ABCB9 0.7 8.57 0.47 8.55e-16 Neutrophil percentage of white cells; CESC cis rs9611565 0.512 rs139566 chr22:42199277 A/G cg06634786 chr22:41940651 POLR3H -0.67 -6.64 -0.38 1.74e-10 Vitiligo; CESC cis rs28647808 1.000 rs2285483 chr9:136271838 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.95 10.4 0.54 1.85e-21 Mean platelet volume; CESC cis rs1005277 0.522 rs9417256 chr10:37976990 A/G cg25517755 chr10:38738941 LOC399744 -0.42 -5.42 -0.32 1.35e-7 Extrinsic epigenetic age acceleration; CESC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg13918804 chr1:2043761 PRKCZ 0.28 5.31 0.31 2.31e-7 Height; CESC cis rs4237845 0.537 rs59401446 chr12:58259564 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.51 5.72 0.33 2.82e-8 Intelligence (multi-trait analysis); CESC cis rs477692 0.647 rs524804 chr10:131430686 G/A cg05714579 chr10:131428358 MGMT -0.6 -8.72 -0.47 3.18e-16 Response to temozolomide; CESC cis rs6570726 0.516 rs9322025 chr6:145729196 C/T cg23711669 chr6:146136114 FBXO30 0.52 6.65 0.38 1.69e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg00802000 chr16:706648 WDR90 -0.43 -6.55 -0.37 3.05e-10 Height; CESC cis rs459571 0.959 rs2520100 chr9:136918137 A/T cg13789015 chr9:136890014 NCRNA00094 0.57 8.06 0.44 2.59e-14 Platelet distribution width; CESC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg17376030 chr22:41985996 PMM1 -0.79 -8.37 -0.46 3.43e-15 Crohn's disease;Inflammatory bowel disease; CESC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.76 0.55 1.2e-22 Height; CESC cis rs13040088 1.000 rs6090159 chr20:61531351 C/G cg23096297 chr20:61557774 DIDO1 0.89 10.14 0.53 1.26e-20 Menopause (age at onset); CESC cis rs7824557 0.568 rs35747588 chr8:11206627 C/G cg21775007 chr8:11205619 TDH 0.58 8.81 0.48 1.71e-16 Retinal vascular caliber; CESC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg01988459 chr11:68622903 NA -0.39 -5.42 -0.32 1.37e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg04234412 chr22:24373322 LOC391322 -0.61 -8.69 -0.47 3.86e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6570726 0.791 rs4896820 chr6:145894957 T/C cg23711669 chr6:146136114 FBXO30 0.83 12.51 0.61 1.62e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7937682 0.883 rs12804962 chr11:111442683 A/T cg09085632 chr11:111637200 PPP2R1B 0.89 12.45 0.61 2.58e-28 Primary sclerosing cholangitis; CESC cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg05343316 chr1:45956843 TESK2 -0.51 -6.75 -0.38 9.49e-11 High light scatter reticulocyte count; CESC cis rs9527 0.590 rs2182348 chr10:104872684 A/G cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs7927771 1.000 rs9909 chr11:47799775 C/G cg20307385 chr11:47447363 PSMC3 -0.51 -6.24 -0.36 1.7e-9 Subjective well-being; CESC trans rs7666738 0.830 rs4292341 chr4:98959724 C/T cg01391346 chr6:99873300 SFRS18 0.41 6.11 0.35 3.58e-9 Colonoscopy-negative controls vs population controls; CESC cis rs10191773 0.589 rs72833410 chr2:113054119 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.68 -7.37 -0.41 2.23e-12 Yeast infection; CESC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg05535760 chr7:792225 HEATR2 0.96 10.78 0.55 1.04e-22 Cerebrospinal P-tau181p levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17298437 chr19:5805096 NA -0.48 -6.17 -0.35 2.53e-9 Ulcerative colitis; CESC cis rs796364 0.951 rs10931888 chr2:201022952 T/G cg23649088 chr2:200775458 C2orf69 -0.52 -5.09 -0.3 6.65e-7 Schizophrenia; CESC cis rs637571 0.607 rs574586 chr11:65697083 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.46 5.83 0.34 1.63e-8 Eosinophil percentage of white cells; CESC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg23283495 chr1:209979779 IRF6 0.53 6.34 0.36 9.65e-10 Cleft lip with or without cleft palate; CESC cis rs2760061 0.583 rs1774757 chr1:228211135 C/G cg02753203 chr1:228287806 NA 0.8 11.29 0.57 2.17e-24 Diastolic blood pressure; CESC cis rs3820928 0.967 rs4675113 chr2:227766339 G/A cg05526886 chr2:227700861 RHBDD1 -0.43 -5.63 -0.33 4.53e-8 Pulmonary function; CESC cis rs9549260 0.620 rs9532580 chr13:41244260 T/C cg21288729 chr13:41239152 FOXO1 0.58 6.3 0.36 1.23e-9 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10795676 chr6:26370623 BTN3A2 -0.57 -6.59 -0.38 2.34e-10 Gut microbiome composition (summer); CESC cis rs7408868 1.000 rs7250232 chr19:15277199 C/T cg14696996 chr19:15285081 NOTCH3 0.89 8.5 0.46 1.42e-15 Pulse pressure; CESC cis rs7267979 1.000 rs4815408 chr20:25346678 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -16.53 -0.71 1.11e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs829883 1.000 rs249819 chr12:98897265 T/A cg25150519 chr12:98850993 NA 0.66 8.75 0.47 2.57e-16 Colorectal adenoma (advanced); CESC cis rs5769765 0.865 rs10854860 chr22:50320029 G/T cg02269571 chr22:50332266 NA -0.55 -6.42 -0.37 6.1e-10 Schizophrenia; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg15605918 chr19:3501056 DOHH -0.45 -6.17 -0.35 2.57e-9 Thyroid stimulating hormone; CESC cis rs12530845 0.623 rs7798256 chr7:135344211 C/A cg23117316 chr7:135346802 PL-5283 -0.6 -6.51 -0.37 3.73e-10 Red blood cell traits; CESC cis rs7903847 0.642 rs2275090 chr10:99148151 A/G cg20016023 chr10:99160130 RRP12 -0.29 -5.06 -0.3 7.89e-7 Granulocyte percentage of myeloid white cells; CESC trans rs11088226 0.681 rs2833891 chr21:33928821 A/G cg09050820 chr6:167586206 TCP10L2 0.82 8.68 0.47 4.09e-16 Gastritis; CESC cis rs4253772 1.000 rs4253772 chr22:46627603 C/T cg18190219 chr22:46762943 CELSR1 -0.67 -5.9 -0.34 1.11e-8 LDL cholesterol;Cholesterol, total; CESC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg16743903 chr16:89593216 SPG7 -0.41 -5.09 -0.3 6.76e-7 Multiple myeloma (IgH translocation); CESC cis rs7044106 0.762 rs10491783 chr9:123450155 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.83 0.34 1.58e-8 Hip circumference adjusted for BMI; CESC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.15 0.4 8.26e-12 Height; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg13456812 chr6:167369504 RNASET2 -0.48 -6.6 -0.38 2.18e-10 Height; CESC cis rs8072100 0.754 rs8081717 chr17:45653921 T/A cg08085267 chr17:45401833 C17orf57 0.44 5.9 0.34 1.12e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg13607699 chr17:42295918 UBTF 0.42 5.44 0.32 1.23e-7 Bone mineral density (hip);Bone mineral density; CESC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg05340658 chr4:99064831 C4orf37 0.82 12.87 0.62 9.38e-30 Colonoscopy-negative controls vs population controls; CESC cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg23649088 chr2:200775458 C2orf69 0.55 5.33 0.31 2.14e-7 Schizophrenia; CESC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg00149659 chr3:10157352 C3orf10 0.75 9.05 0.49 3.07e-17 Alzheimer's disease; CESC cis rs79976124 0.879 rs78012385 chr6:66618091 G/A cg07460842 chr6:66804631 NA 0.75 8.76 0.47 2.39e-16 Type 2 diabetes; CESC cis rs3791556 0.661 rs3791539 chr2:240102327 C/T cg03281426 chr2:240109471 HDAC4 0.5 5.98 0.34 7.23e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01688141 chr8:23539808 NKX3-1 -0.44 -6.23 -0.36 1.81e-9 Gambling; CESC cis rs4474465 0.831 rs7121299 chr11:78189133 G/T cg27205649 chr11:78285834 NARS2 -0.42 -5.23 -0.31 3.4e-7 Alzheimer's disease (survival time); CESC cis rs9457247 1.000 rs415842 chr6:167406681 G/A cg07741184 chr6:167504864 NA 0.29 5.31 0.31 2.32e-7 Crohn's disease; CESC cis rs9788682 0.947 rs12439240 chr15:78829091 T/C cg06917634 chr15:78832804 PSMA4 -0.58 -6.94 -0.39 2.92e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs926938 0.584 rs2798663 chr1:115363582 G/A cg12756093 chr1:115239321 AMPD1 0.43 5.9 0.34 1.09e-8 Autism; CESC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg04414720 chr1:150670196 GOLPH3L 0.51 6.76 0.38 8.61e-11 Melanoma; CESC cis rs9290065 0.538 rs6809206 chr3:160755708 G/A cg03342759 chr3:160939853 NMD3 -0.38 -5.12 -0.3 5.91e-7 Kawasaki disease; CESC cis rs7312774 0.618 rs4964513 chr12:107375758 T/C cg16260113 chr12:107380972 MTERFD3 0.97 7.63 0.42 4.27e-13 Severe influenza A (H1N1) infection; CESC cis rs35110281 0.632 rs9306160 chr21:45107562 T/C cg01579765 chr21:45077557 HSF2BP -0.54 -8.95 -0.48 6.29e-17 Mean corpuscular volume; CESC cis rs7659604 1.000 rs7660078 chr4:122665577 G/T cg19671926 chr4:122722719 EXOSC9 -0.49 -5.95 -0.34 8.28e-9 Type 2 diabetes; CESC cis rs116095464 0.558 rs10075018 chr5:239175 G/A cg22857025 chr5:266934 NA -1.27 -18.31 -0.75 6.06e-49 Breast cancer; CESC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg22968622 chr17:43663579 NA 1.36 18.72 0.75 2.16e-50 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs56104184 0.775 rs117016425 chr19:49400216 C/T cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs11098499 0.909 rs71614422 chr4:120359340 G/A cg25214090 chr10:38739885 LOC399744 0.71 10.01 0.52 3.2e-20 Corneal astigmatism; CESC cis rs4423214 0.921 rs12807827 chr11:71203790 A/C cg24826892 chr11:71159390 DHCR7 0.45 5.16 0.3 4.88e-7 Vitamin D levels; CESC cis rs7959452 0.640 rs1598543 chr12:69688757 G/T cg20891283 chr12:69753455 YEATS4 0.75 11.01 0.56 1.86e-23 Blood protein levels; CESC cis rs10845606 1.000 rs10845605 chr12:12833468 T/C cg04607235 chr12:12878440 APOLD1 -0.71 -7.86 -0.43 9.54e-14 Systemic lupus erythematosus; CESC cis rs9457247 0.967 rs377753 chr6:167389496 A/T cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs6087990 0.765 rs6058900 chr20:31400673 T/C cg13636640 chr20:31349939 DNMT3B 0.9 15.0 0.68 3.16e-37 Ulcerative colitis; CESC cis rs7527798 0.592 rs11118282 chr1:207832402 G/A cg21110645 chr1:207815933 NA -0.32 -5.62 -0.33 4.92e-8 Erythrocyte sedimentation rate; CESC cis rs61931739 0.517 rs34760282 chr12:34153711 G/T cg19457237 chr12:34500585 NA -0.39 -5.35 -0.31 1.93e-7 Morning vs. evening chronotype; CESC cis rs933688 0.759 rs1423593 chr5:90752351 T/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.12 12.64 0.61 5.66e-29 Smoking behavior; CESC cis rs9467711 0.523 rs9379853 chr6:26357635 A/G cg14345882 chr6:26364793 BTN3A2 0.59 6.06 0.35 4.66e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9916302 0.904 rs7223438 chr17:37521355 T/C cg00129232 chr17:37814104 STARD3 0.52 6.49 0.37 4.19e-10 Glomerular filtration rate (creatinine); CESC cis rs6782228 1.000 rs6775011 chr3:128396483 T/C cg15607142 chr3:128420513 NA -0.38 -5.19 -0.3 4.24e-7 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg24846343 chr22:24311635 DDTL 0.6 10.01 0.52 3.34e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10489202 0.632 rs413168 chr1:168005789 C/G cg24449463 chr1:168025552 DCAF6 -0.4 -5.12 -0.3 5.94e-7 Schizophrenia; CESC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg16606324 chr3:10149918 C3orf24 0.43 5.36 0.31 1.81e-7 Alzheimer's disease; CESC cis rs910316 0.967 rs4899549 chr14:75647494 G/A cg08847533 chr14:75593920 NEK9 -0.94 -16.62 -0.71 5.67e-43 Height; CESC trans rs8007846 0.569 rs4400971 chr14:66254578 A/C cg05684300 chr4:102267366 PPP3CA 0.47 6.48 0.37 4.36e-10 Multiple sclerosis--Brain Glutamate Levels; CESC cis rs9303401 0.659 rs7224276 chr17:56897827 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.68 0.61 4.11e-29 Cognitive test performance; CESC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.821 rs1966915 chr17:37425262 A/C cg07936489 chr17:37558343 FBXL20 -0.8 -11.48 -0.58 5.11e-25 Glomerular filtration rate (creatinine); CESC cis rs826838 0.616 rs2200605 chr12:38624088 G/A cg26384229 chr12:38710491 ALG10B 0.47 6.69 0.38 1.34e-10 Heart rate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14311538 chr9:139348775 SEC16A 0.5 6.64 0.38 1.75e-10 Fibrinogen levels; CESC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.25 0.53 5.71e-21 Prudent dietary pattern; CESC cis rs7659604 1.000 rs6823488 chr4:122664819 A/G cg19671926 chr4:122722719 EXOSC9 -0.43 -5.27 -0.31 2.78e-7 Type 2 diabetes; CESC cis rs12134245 1.000 rs12134245 chr1:92021464 C/T cg25838465 chr1:92012736 NA -0.38 -5.17 -0.3 4.59e-7 Breast cancer; CESC cis rs7246657 0.943 rs2291004 chr19:37997952 C/A cg23950597 chr19:37808831 NA -0.62 -6.38 -0.36 7.88e-10 Coronary artery calcification; CESC cis rs7680126 0.672 rs4697957 chr4:10182254 A/G cg00071950 chr4:10020882 SLC2A9 -0.51 -5.53 -0.32 7.58e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12592965 chr5:177631661 HNRNPAB -0.5 -6.71 -0.38 1.18e-10 Fibrinogen levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24615751 chr1:40723984 ZMPSTE24 -0.44 -6.06 -0.35 4.55e-9 Asthma; CESC cis rs57506017 0.585 rs1042949 chr7:12272116 C/G cg23422036 chr7:12250390 TMEM106B 0.39 5.17 0.3 4.57e-7 Neuroticism; CESC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg05863683 chr7:1912471 MAD1L1 0.37 5.4 0.31 1.46e-7 Schizophrenia; CESC cis rs4843747 0.671 rs28679286 chr16:88106307 C/T cg17633681 chr16:88106987 BANP 0.76 10.51 0.54 8.01e-22 Menopause (age at onset); CESC trans rs11098499 0.865 rs11722183 chr4:120280597 A/C cg25214090 chr10:38739885 LOC399744 0.68 9.35 0.5 3.7e-18 Corneal astigmatism; CESC cis rs11971779 1.000 rs75919582 chr7:139054919 G/A cg07862535 chr7:139043722 LUC7L2 0.55 5.19 0.3 4.12e-7 Diisocyanate-induced asthma; CESC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.7 0.38 1.22e-10 Bipolar disorder; CESC cis rs3204270 0.759 rs8071492 chr17:79682650 G/A cg18367735 chr17:79674897 NA 0.74 6.59 0.38 2.39e-10 Dental caries; CESC cis rs10861342 1.000 rs11112368 chr12:105494218 T/C cg23923672 chr12:105501055 KIAA1033 0.69 5.91 0.34 1.07e-8 IgG glycosylation; CESC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg12311346 chr5:56204834 C5orf35 -0.47 -5.63 -0.33 4.59e-8 Coronary artery disease; CESC cis rs6860806 0.531 rs274556 chr5:131722075 A/G cg18758796 chr5:131593413 PDLIM4 -0.42 -5.75 -0.33 2.45e-8 Breast cancer; CESC cis rs7208859 0.573 rs7223803 chr17:29077193 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12220238 1.000 rs4745740 chr10:75942469 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.61 5.82 0.34 1.69e-8 Soluble interleukin-2 receptor subunit alpha; CESC cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg17724175 chr1:150552817 MCL1 -0.32 -5.26 -0.31 2.93e-7 Tonsillectomy; CESC cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg12698349 chr2:225449008 CUL3 -0.59 -8.44 -0.46 2.1e-15 IgE levels in asthmatics (D.p. specific); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12588476 chr7:99647494 ZSCAN21 0.69 8.13 0.45 1.7e-14 Gut microbiome composition (summer); CESC cis rs4849845 0.889 rs4849846 chr2:121026891 T/C cg24070213 chr2:121070622 NA 0.39 5.04 0.3 8.71e-7 Mean platelet volume; CESC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg16262614 chr3:133464971 TF 0.29 5.14 0.3 5.29e-7 Iron status biomarkers; CESC cis rs7605827 0.930 rs4668446 chr2:15516020 C/T cg19274914 chr2:15703543 NA 0.31 5.39 0.31 1.55e-7 Educational attainment (years of education); CESC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg24549020 chr5:56110836 MAP3K1 0.66 7.45 0.42 1.29e-12 Initial pursuit acceleration; CESC cis rs71444571 1 rs71444571 chr12:123771015 G/A cg00376283 chr12:123451042 ABCB9 -0.62 -6.4 -0.37 7.02e-10 Lymphocyte percentage of white cells; CESC cis rs72829446 0.556 rs12936464 chr17:7403942 A/C cg02795151 chr17:7402630 POLR2A -0.57 -6.68 -0.38 1.42e-10 Androgen levels; CESC cis rs3015497 0.506 rs6572689 chr14:51168325 T/C cg26011998 chr14:51135199 SAV1 -0.55 -6.15 -0.35 2.8e-9 Mean platelet volume; CESC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg07701084 chr6:150067640 NUP43 0.41 5.41 0.32 1.41e-7 Lung cancer; CESC cis rs754466 0.651 rs11815015 chr10:79625482 C/T cg17075019 chr10:79541650 NA -0.86 -13.15 -0.63 9.74e-31 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12887734 0.524 rs4906363 chr14:104210239 G/A cg01849466 chr14:104193079 ZFYVE21 -0.44 -5.46 -0.32 1.1e-7 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs7680126 0.596 rs10939723 chr4:10139105 G/T cg11266682 chr4:10021025 SLC2A9 -0.38 -5.25 -0.31 3.17e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs10754283 0.901 rs4520403 chr1:90112840 T/G cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs3820068 0.608 rs12092485 chr1:16048038 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.78 0.33 2.06e-8 Systolic blood pressure; CESC cis rs868036 0.756 rs2241421 chr15:68082825 G/A cg08079166 chr15:68083412 MAP2K5 0.45 7.05 0.4 1.53e-11 Restless legs syndrome; CESC cis rs12618769 0.597 rs6753515 chr2:99128965 T/A cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs61996546 0.622 rs12901009 chr15:26855181 C/G cg14859324 chr15:26874363 GABRB3 -0.37 -5.06 -0.3 7.97e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs7216064 1.000 rs4790908 chr17:65852907 T/G cg07042672 chr17:66097459 LOC651250 -0.57 -6.56 -0.37 2.74e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6088580 0.634 rs6059867 chr20:33078103 C/T cg08999081 chr20:33150536 PIGU 0.66 11.68 0.58 1.03e-25 Glomerular filtration rate (creatinine); CESC cis rs2933343 0.621 rs4927921 chr3:128568868 A/G cg24203234 chr3:128598194 ACAD9 -0.47 -6.58 -0.37 2.51e-10 IgG glycosylation; CESC cis rs228437 1.000 rs6928242 chr6:134936389 T/G cg24504307 chr6:134963096 NA 0.56 5.98 0.34 7.38e-9 Melanoma; CESC cis rs939574 0.722 rs115402093 chr2:220096128 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 7.02 0.4 1.85e-11 Platelet distribution width; CESC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg11890956 chr21:40555474 PSMG1 -0.93 -15.11 -0.68 1.23e-37 Cognitive function; CESC cis rs3857067 1.000 rs2865330 chr4:95004716 A/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3e-14 QT interval; CESC cis rs2075671 0.857 rs11772849 chr7:100308412 G/A cg20848291 chr7:100343083 ZAN -0.73 -9.16 -0.49 1.5e-17 Other erythrocyte phenotypes; CESC cis rs7605827 0.866 rs13014988 chr2:15498404 C/T cg19274914 chr2:15703543 NA 0.31 5.63 0.33 4.57e-8 Educational attainment (years of education); CESC cis rs2404618 0.593 rs7815979 chr8:1484887 A/G cg13402656 chr8:1511478 DLGAP2 -0.55 -8.01 -0.44 3.57e-14 Lung cancer; CESC cis rs6963495 0.745 rs75805443 chr7:105162828 A/G cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs3806843 1.000 rs6898939 chr5:140169355 C/A cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.19 -0.3 4.21e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9325144 0.600 rs12424410 chr12:38758035 A/T cg26384229 chr12:38710491 ALG10B -0.57 -7.91 -0.44 6.79e-14 Morning vs. evening chronotype; CESC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs660498 0.507 rs765700 chr10:27734885 G/A cg25705717 chr10:27608719 NA 0.48 5.82 0.34 1.73e-8 Asthma (childhood onset); CESC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg22920501 chr2:26401640 FAM59B 0.72 8.03 0.44 3.27e-14 Gut microbiome composition (summer); CESC cis rs6456156 0.586 rs2345753 chr6:167484344 T/A cg23791538 chr6:167370224 RNASET2 -0.51 -6.44 -0.37 5.67e-10 Primary biliary cholangitis; CESC cis rs644799 1.000 rs11021319 chr11:95523123 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 14.22 0.66 1.74e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg12463550 chr7:65579703 CRCP 0.57 7.18 0.4 6.93e-12 Aortic root size; CESC cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg08847533 chr14:75593920 NEK9 -0.94 -16.53 -0.71 1.17e-42 Height; CESC trans rs6084875 0.641 rs6052810 chr20:4722964 A/C cg10192164 chr16:30419175 ZNF771 -0.51 -6.18 -0.35 2.44e-9 Systemic lupus erythematosus; CESC cis rs2439831 0.681 rs1549523 chr15:43624189 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.95 0.56 2.88e-23 Lung cancer in ever smokers; CESC cis rs9814567 1.000 rs6766897 chr3:134191303 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.41 -5.64 -0.33 4.25e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.71 11.5 0.58 4.37e-25 Personality dimensions; CESC cis rs2455799 0.573 rs2455833 chr3:15752830 T/C cg09340198 chr3:15902540 ANKRD28 -0.33 -5.27 -0.31 2.87e-7 Mean platelet volume; CESC cis rs2455799 0.613 rs3856830 chr3:15806520 A/C cg16303742 chr3:15540471 COLQ -0.4 -6.23 -0.36 1.83e-9 Mean platelet volume; CESC cis rs6667605 0.506 rs10797440 chr1:2541269 A/G cg18854424 chr1:2615690 NA 0.3 6.01 0.35 6.23e-9 Inflammatory bowel disease;Ulcerative colitis; CESC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg06873352 chr17:61820015 STRADA 0.71 12.48 0.61 2.02e-28 Prudent dietary pattern; CESC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg12463550 chr7:65579703 CRCP -0.54 -6.65 -0.38 1.65e-10 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05246657 chr6:52930357 FBXO9 0.53 6.01 0.35 6.23e-9 Gut microbiome composition (summer); CESC cis rs2011503 1.000 rs4808206 chr19:19645645 C/A cg11584989 chr19:19387371 SF4 0.61 6.98 0.39 2.41e-11 Bipolar disorder; CESC cis rs6545883 0.931 rs7557230 chr2:61736652 A/T cg15711740 chr2:61764176 XPO1 -0.43 -5.35 -0.31 1.91e-7 Tuberculosis; CESC cis rs10463316 0.817 rs6895187 chr5:150775909 G/A cg03212797 chr5:150827313 SLC36A1 -0.45 -5.94 -0.34 9.07e-9 Metabolite levels (Pyroglutamine); CESC cis rs3857067 1.000 rs7685048 chr4:95027784 C/T cg11021082 chr4:95130006 SMARCAD1 -0.53 -8.12 -0.45 1.77e-14 QT interval; CESC cis rs9910055 0.573 rs228768 chr17:42191893 A/C cg10896456 chr17:42255109 ASB16;C17orf65 0.37 5.36 0.31 1.79e-7 Total body bone mineral density; CESC cis rs317689 0.581 rs315132 chr12:69761996 G/C cg20891283 chr12:69753455 YEATS4 0.75 10.03 0.52 2.83e-20 Response to diuretic therapy; CESC cis rs718433 0.584 rs1002180 chr14:22217052 C/T cg02257791 chr14:22217085 NA -0.32 -5.08 -0.3 7.27e-7 Intraocular pressure; CESC cis rs6690583 1.000 rs6690583 chr1:85466337 A/G cg22153463 chr1:85462885 MCOLN2 -0.77 -9.39 -0.5 2.81e-18 Serum sulfate level; CESC cis rs2721195 0.626 rs59464125 chr8:145857786 G/A cg15857475 chr8:145742913 RECQL4;LRRC14 -0.67 -9.69 -0.51 3.4e-19 Age at first birth; CESC cis rs2439831 0.867 rs4583210 chr15:43660925 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.92 11.29 0.57 2.11e-24 Lung cancer in ever smokers; CESC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg18758796 chr5:131593413 PDLIM4 0.46 6.48 0.37 4.48e-10 Breast cancer; CESC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg10570241 chr7:158785291 NA 0.31 5.25 0.31 3.15e-7 Facial morphology (factor 20); CESC trans rs459571 0.920 rs2520094 chr9:136919985 A/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.63 -8.22 -0.45 8.91e-15 Platelet distribution width; CESC cis rs3733585 0.664 rs17245436 chr4:9958169 A/G cg00071950 chr4:10020882 SLC2A9 -0.72 -11.7 -0.58 8.89e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3126085 0.935 rs3126091 chr1:152307338 T/C cg03465714 chr1:152285911 FLG 0.41 5.18 0.3 4.36e-7 Atopic dermatitis; CESC cis rs6709815 0.902 rs13020432 chr2:219668211 C/T cg02176678 chr2:219576539 TTLL4 -0.34 -5.81 -0.34 1.77e-8 Reticulocyte count;High light scatter reticulocyte count; CESC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg22143856 chr6:28129313 ZNF389 -0.42 -5.56 -0.32 6.72e-8 Depression; CESC cis rs6121246 0.909 rs6060923 chr20:30336655 A/C cg13852791 chr20:30311386 BCL2L1 0.82 8.74 0.47 2.63e-16 Mean corpuscular hemoglobin; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01088093 chr15:75748402 SIN3A -0.39 -6.24 -0.36 1.68e-9 Gambling; CESC cis rs7726839 0.794 rs6883536 chr5:599274 G/A cg16447950 chr5:562315 NA -0.49 -5.72 -0.33 2.88e-8 Obesity-related traits; CESC cis rs11997175 0.625 rs7825931 chr8:33583627 A/C ch.8.33884649F chr8:33765107 NA -0.49 -5.84 -0.34 1.51e-8 Body mass index; CESC cis rs4148883 0.689 rs2851275 chr4:100024883 A/G cg13256891 chr4:100009986 ADH5 0.54 7.3 0.41 3.37e-12 Alcohol dependence; CESC cis rs6987853 0.661 rs4641053 chr8:42352161 G/A cg09913449 chr8:42400586 C8orf40 -0.36 -5.9 -0.34 1.11e-8 Mean corpuscular hemoglobin concentration; CESC cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg10523679 chr1:76189770 ACADM 0.87 13.69 0.64 1.21e-32 Blood metabolite levels;Acylcarnitine levels; CESC cis rs941873 0.836 rs6480931 chr10:81108482 T/C cg09469691 chr10:81107165 PPIF 0.53 7.02 0.4 1.82e-11 Height; CESC cis rs7129220 0.588 rs7124925 chr11:10143700 G/A cg01453529 chr11:10209919 SBF2 -0.48 -5.63 -0.33 4.67e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs6785206 0.614 rs2712430 chr3:128337438 A/C cg16766828 chr3:128327626 NA -0.63 -6.49 -0.37 4.31e-10 Lymphocyte percentage of white cells; CESC cis rs7267979 0.932 rs417110 chr20:25458297 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.78 0.67 1.87e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs4588572 0.645 rs10059940 chr5:77680873 T/C cg11547950 chr5:77652471 NA 0.46 5.91 0.34 1.06e-8 Triglycerides; CESC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 11.0 0.56 1.98e-23 Platelet count; CESC cis rs59918340 0.616 rs3739222 chr8:142205904 C/G cg18755752 chr8:142205143 DENND3 -0.48 -6.55 -0.37 3.01e-10 Immature fraction of reticulocytes; CESC cis rs1371867 0.875 rs1612773 chr8:101337818 G/C cg11906718 chr8:101322791 RNF19A 0.48 6.1 0.35 3.7e-9 Atrioventricular conduction; CESC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.647 rs11072607 chr15:76908529 C/T cg23625390 chr15:77176239 SCAPER -0.45 -6.17 -0.35 2.48e-9 Blood metabolite levels; CESC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg07701084 chr6:150067640 NUP43 0.4 5.49 0.32 9.18e-8 Lung cancer; CESC cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg12463550 chr7:65579703 CRCP 0.68 5.42 0.32 1.36e-7 Diabetic kidney disease; CESC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.21 -0.3 3.76e-7 Lung cancer; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg19245296 chr20:10015646 ANKRD5 0.41 6.05 0.35 4.92e-9 Vertical cup-disc ratio; CESC trans rs7902708 0.920 rs7895388 chr10:54423387 A/G cg26219051 chr22:43739629 SCUBE1 -0.48 -6.19 -0.36 2.25e-9 Bone properties (heel); CESC cis rs796364 1.000 rs281774 chr2:200814572 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.87 8.59 0.47 7.81e-16 Schizophrenia; CESC cis rs11792861 0.926 rs72607173 chr9:111879398 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 5.31 0.31 2.28e-7 Menarche (age at onset); CESC cis rs3540 0.618 rs11609 chr15:91043765 C/G cg22089800 chr15:90895588 ZNF774 -0.62 -8.14 -0.45 1.56e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs4642101 0.611 rs6442331 chr3:12820636 T/G cg24848339 chr3:12840334 CAND2 0.41 6.36 0.36 8.91e-10 QRS complex (12-leadsum); CESC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg18451016 chr1:38461880 NA -0.41 -5.64 -0.33 4.36e-8 Coronary artery disease; CESC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg01988459 chr11:68622903 NA -0.42 -5.43 -0.32 1.27e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6460942 0.597 rs13232817 chr7:12551909 C/A cg02935154 chr7:12443704 VWDE -0.55 -5.24 -0.31 3.31e-7 Coronary artery disease; CESC cis rs3806843 0.735 rs2530240 chr5:140060547 T/C cg16179182 chr5:140090404 VTRNA1-1 0.39 5.11 0.3 6.21e-7 Depressive symptoms (multi-trait analysis); CESC cis rs10242455 0.867 rs2037499 chr7:99312653 C/G cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.06 10.91 0.56 3.9e-23 Platelet count; CESC cis rs3820068 0.562 rs10927841 chr1:16045261 T/C cg13390004 chr1:15929781 NA 0.34 5.19 0.3 4.22e-7 Systolic blood pressure; CESC cis rs4253772 0.637 rs9627295 chr22:46650100 C/T cg09491104 chr22:46646882 C22orf40 -0.59 -9.15 -0.49 1.58e-17 LDL cholesterol;Cholesterol, total; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23681110 chr8:140847721 TRAPPC9 0.46 6.14 0.35 2.94e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07613930 chr12:117316665 HRK -0.66 -8.15 -0.45 1.47e-14 Gut microbiome composition (summer); CESC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg27170947 chr2:26402098 FAM59B -0.82 -9.69 -0.51 3.29e-19 Gut microbiome composition (summer); CESC cis rs7772486 0.566 rs735536 chr6:146036832 A/C cg05347473 chr6:146136440 FBXO30 -0.53 -6.99 -0.39 2.19e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9581857 0.725 rs9581853 chr13:28016236 T/C cg22138327 chr13:27999177 GTF3A 0.67 5.46 0.32 1.12e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg17372223 chr3:52568218 NT5DC2 0.55 9.24 0.49 8.55e-18 Electroencephalogram traits; CESC cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg25019033 chr10:957182 NA -0.58 -6.3 -0.36 1.2e-9 Eosinophil percentage of granulocytes; CESC cis rs12142240 0.698 rs17361791 chr1:46812519 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.85 0.43 1.05e-13 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00840257 chr16:8963031 CARHSP1 -0.48 -6.08 -0.35 4.08e-9 Ulcerative colitis; CESC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg11663144 chr21:46675770 NA -0.62 -9.82 -0.52 1.27e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04840494 chr5:79550959 SERINC5 -0.63 -7.29 -0.41 3.6e-12 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs781156 chr7:65479141 C/A cg13147721 chr7:65941812 NA -0.89 -8.55 -0.47 9.65e-16 Diabetic kidney disease; CESC cis rs9640161 0.750 rs3800780 chr7:150027284 C/A cg17279839 chr7:150038598 RARRES2 0.43 5.19 0.3 4.24e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg22920501 chr2:26401640 FAM59B 0.72 8.12 0.45 1.74e-14 Gut microbiome composition (summer); CESC cis rs3857067 0.967 rs7668980 chr4:95037320 G/A cg11021082 chr4:95130006 SMARCAD1 -0.52 -7.95 -0.44 5.37e-14 QT interval; CESC trans rs17685 0.753 rs6951943 chr7:75772452 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 12.4 0.61 3.88e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg08847533 chr14:75593920 NEK9 -1.01 -18.52 -0.75 1.04e-49 Height; CESC cis rs778371 0.676 rs13024330 chr2:233715487 A/G cg08000102 chr2:233561755 GIGYF2 0.81 12.42 0.61 3.19e-28 Schizophrenia; CESC cis rs1559088 0.600 rs7255229 chr19:33562807 A/G cg27124370 chr19:33622961 WDR88 0.54 7.5 0.42 9.47e-13 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7246657 0.943 rs4452075 chr19:37879589 A/G cg23950597 chr19:37808831 NA -0.55 -5.97 -0.34 7.77e-9 Coronary artery calcification; CESC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.14 0.3 5.31e-7 Personality dimensions; CESC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg04944784 chr2:26401820 FAM59B -0.96 -10.83 -0.55 7.34e-23 Gut microbiome composition (summer); CESC cis rs4711336 1.000 rs764754 chr6:33658310 C/T cg14003231 chr6:33640908 ITPR3 0.32 5.46 0.32 1.07e-7 Height; CESC cis rs546131 0.928 rs552868 chr11:34830694 G/A cg06937548 chr11:34938143 PDHX;APIP 0.53 6.72 0.38 1.09e-10 Lung disease severity in cystic fibrosis; CESC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.63 0.51 5.12e-19 Platelet count; CESC cis rs7247513 0.701 rs8107642 chr19:12766370 C/T cg06417478 chr19:12876846 HOOK2 0.43 5.25 0.31 3.11e-7 Bipolar disorder; CESC cis rs62005083 1.000 rs62006760 chr14:74615095 G/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.74 5.42 0.32 1.34e-7 Mean corpuscular volume; CESC cis rs2243480 1.000 rs4145008 chr7:65647511 T/G cg12463550 chr7:65579703 CRCP -0.73 -5.66 -0.33 4.03e-8 Diabetic kidney disease; CESC trans rs561341 0.883 rs72821942 chr17:30234460 C/T cg20587970 chr11:113659929 NA -1.09 -13.14 -0.63 1.04e-30 Hip circumference adjusted for BMI; CESC cis rs10479542 0.929 rs10078796 chr5:178978883 T/A cg00080972 chr5:178986291 RUFY1 0.44 7.02 0.4 1.88e-11 Lung cancer; CESC cis rs6439153 0.967 rs61480393 chr3:128699759 T/C cg25356066 chr3:128598488 ACAD9 0.51 6.5 0.37 3.9e-10 Pneumococcal bacteremia; CESC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg26408565 chr15:76604113 ETFA -0.4 -5.89 -0.34 1.19e-8 Blood metabolite levels; CESC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg13393036 chr8:95962371 TP53INP1 0.47 9.09 0.49 2.33e-17 Type 2 diabetes; CESC cis rs2635047 0.542 rs2684814 chr18:44754103 C/T cg24371990 chr18:44770781 NA -0.34 -5.51 -0.32 8.31e-8 Educational attainment; CESC cis rs5758659 0.967 rs5751250 chr22:42639645 T/G cg15557168 chr22:42548783 NA -0.49 -7.72 -0.43 2.34e-13 Cognitive function; CESC cis rs2739330 0.892 rs5751776 chr22:24266954 A/C cg23131131 chr22:24373011 LOC391322 -0.76 -11.11 -0.56 8.7e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg13770153 chr20:60521292 NA -0.5 -6.58 -0.37 2.55e-10 Body mass index; CESC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.45e-21 Prudent dietary pattern; CESC cis rs8060686 0.545 rs8056649 chr16:68260083 A/G cg26727032 chr16:67993705 SLC12A4 0.44 5.49 0.32 9.33e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg23172400 chr8:95962367 TP53INP1 -0.5 -11.1 -0.56 9.09e-24 Type 2 diabetes; CESC cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg17366294 chr4:99064904 C4orf37 0.6 8.49 0.46 1.46e-15 Colonoscopy-negative controls vs population controls; CESC cis rs72945132 0.882 rs55738915 chr11:70190019 C/T cg00319359 chr11:70116639 PPFIA1 0.79 7.41 0.41 1.66e-12 Coronary artery disease; CESC cis rs4654899 0.802 rs12401413 chr1:21236503 T/C cg05370193 chr1:21551575 ECE1 0.38 5.55 0.32 6.84e-8 Superior frontal gyrus grey matter volume; CESC trans rs7980799 0.654 rs1482987 chr12:33614283 G/C cg26384229 chr12:38710491 ALG10B -0.55 -7.87 -0.44 9.24e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs1912483 0.505 rs11079772 chr17:45393739 A/C cg25173405 chr17:45401733 C17orf57 0.44 5.16 0.3 4.96e-7 Coronary artery disease; CESC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg10546459 chr2:36825355 FEZ2 -0.44 -5.3 -0.31 2.43e-7 Height; CESC cis rs4132509 0.739 rs10803150 chr1:243822600 C/T cg21452805 chr1:244014465 NA 0.59 6.57 0.37 2.72e-10 RR interval (heart rate); CESC cis rs72781680 0.848 rs6754694 chr2:24155448 T/C cg08917208 chr2:24149416 ATAD2B 0.95 8.51 0.46 1.27e-15 Lymphocyte counts; CESC cis rs34375054 0.660 rs12578446 chr12:125605887 A/G cg25124228 chr12:125621409 AACS -0.56 -6.74 -0.38 1e-10 Post bronchodilator FEV1/FVC ratio; CESC cis rs3857067 1.000 rs3846292 chr4:95027717 G/T cg11021082 chr4:95130006 SMARCAD1 -0.53 -8.12 -0.45 1.77e-14 QT interval; CESC cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg27347728 chr4:17578864 LAP3 0.43 5.11 0.3 6.18e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs60380162 0.963 rs28379534 chr1:87709437 G/C cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.0 -0.35 6.63e-9 Loneliness (linear analysis); CESC cis rs7267979 1.000 rs6083828 chr20:25369918 T/C cg08601574 chr20:25228251 PYGB -0.38 -5.53 -0.32 7.83e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs523522 0.962 rs10849759 chr12:120994488 T/A cg12219531 chr12:120966889 COQ5 0.75 9.81 0.52 1.43e-19 High light scatter reticulocyte count; CESC cis rs9287719 0.615 rs12613769 chr2:10742290 C/T cg00105475 chr2:10696890 NA 0.37 5.06 0.3 7.79e-7 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11527367 chr1:144612646 C1orf152 -0.64 -7.94 -0.44 5.59e-14 Gut microbiome composition (summer); CESC cis rs4835473 0.798 rs34353812 chr4:144895102 T/A cg25736465 chr4:144833511 NA 0.38 5.7 0.33 3.22e-8 Immature fraction of reticulocytes; CESC cis rs7017914 0.840 rs13254851 chr8:71689034 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg10074409 chr1:209979377 IRF6 0.37 5.96 0.34 7.83e-9 Cleft lip with or without cleft palate; CESC cis rs2479106 0.591 rs7852243 chr9:126417340 A/G cg16191174 chr9:126692580 DENND1A -0.4 -5.69 -0.33 3.31e-8 Polycystic ovary syndrome; CESC cis rs6964587 0.626 rs12704631 chr7:91523525 T/C cg17063962 chr7:91808500 NA -0.46 -6.48 -0.37 4.55e-10 Breast cancer; CESC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg14393609 chr7:65229607 NA -0.47 -6.31 -0.36 1.16e-9 Aortic root size; CESC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg05863683 chr7:1912471 MAD1L1 0.4 5.89 0.34 1.18e-8 Schizophrenia; CESC cis rs1008375 0.932 rs6835077 chr4:17653285 A/T cg02297831 chr4:17616191 MED28 0.65 8.09 0.44 2.2e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs60733400 0.500 rs72644697 chr1:2533605 G/A cg18854424 chr1:2615690 NA 0.27 5.23 0.31 3.43e-7 Multiple sclerosis; CESC cis rs11078597 0.671 rs34599286 chr17:1645747 C/A cg18436246 chr17:1640651 WDR81 0.62 7.59 0.42 5.36e-13 Serum albumin level; CESC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg17221315 chr6:27791827 HIST1H4J 0.44 5.31 0.31 2.27e-7 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10332367 chr16:2075476 SLC9A3R2 -0.47 -6.2 -0.36 2.15e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07434447 chr7:74489725 WBSCR16 -0.48 -6.57 -0.37 2.71e-10 Fibrinogen levels; CESC cis rs10871290 0.881 rs7498574 chr16:74472661 A/G cg01733217 chr16:74700730 RFWD3 -0.67 -8.85 -0.48 1.27e-16 Breast cancer; CESC cis rs73206853 0.534 rs7131996 chr12:111073276 C/A cg12870014 chr12:110450643 ANKRD13A 0.63 5.68 0.33 3.53e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9300255 0.739 rs1533703 chr12:123742093 T/G cg05973401 chr12:123451056 ABCB9 0.49 5.52 0.32 8.03e-8 Neutrophil percentage of white cells; CESC cis rs763121 0.819 rs6001205 chr22:39100264 T/A cg21395723 chr22:39101663 GTPBP1 0.44 5.44 0.32 1.2e-7 Menopause (age at onset); CESC trans rs875971 0.660 rs10272357 chr7:66063074 G/A cg26939375 chr7:64535504 NA -0.64 -8.62 -0.47 6.24e-16 Aortic root size; CESC cis rs11690935 0.885 rs6725388 chr2:172730015 G/C cg13550731 chr2:172543902 DYNC1I2 -0.86 -13.3 -0.63 2.97e-31 Schizophrenia; CESC cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg02297831 chr4:17616191 MED28 0.51 6.18 0.35 2.44e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg00701064 chr4:6280414 WFS1 -0.67 -11.4 -0.57 9.44e-25 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg09491104 chr22:46646882 C22orf40 -0.51 -6.16 -0.35 2.69e-9 LDL cholesterol;Cholesterol, total; CESC cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg05347473 chr6:146136440 FBXO30 0.55 7.26 0.41 4.4e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09659697 chr5:54529994 CCNO -0.55 -6.38 -0.36 8.08e-10 Gut microbiome composition (summer); CESC cis rs763121 0.814 rs5757212 chr22:39053757 G/C cg06022373 chr22:39101656 GTPBP1 0.95 17.52 0.73 3.72e-46 Menopause (age at onset); CESC cis rs1801251 0.963 rs13424351 chr2:233573629 A/G cg25237894 chr2:233734115 C2orf82 0.49 8.29 0.45 5.67e-15 Coronary artery disease; CESC cis rs13242816 1.000 rs34936262 chr7:116160022 G/A cg04696780 chr7:116139425 CAV2 -0.61 -5.55 -0.32 7.01e-8 P wave duration; CESC cis rs1059312 1.000 rs1059312 chr12:129278864 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.61 8.23 0.45 8.64e-15 Systemic lupus erythematosus; CESC cis rs6594499 0.872 rs13178997 chr5:110444249 G/T cg04022379 chr5:110408740 TSLP 0.34 5.95 0.34 8.43e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.51 6.38 0.36 8.06e-10 Tonsillectomy; CESC cis rs698813 0.572 rs6544749 chr2:44478077 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.44 0.32 1.19e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs9943753 0.508 rs7958071 chr12:109836089 G/A cg19025524 chr12:109796872 NA -0.47 -6.67 -0.38 1.45e-10 HDL cholesterol; CESC trans rs931812 0.895 rs4734013 chr8:101908687 A/C cg20993868 chr7:22813445 NA 0.57 8.09 0.45 2.11e-14 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg07507251 chr3:52567010 NT5DC2 0.32 5.58 0.32 5.88e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13830646 chr11:65668067 FOSL1 0.56 6.98 0.39 2.34e-11 Gut microbiome composition (summer); CESC cis rs763014 0.865 rs8675 chr16:633843 A/G cg07343612 chr16:622815 PIGQ -0.55 -7.95 -0.44 5.41e-14 Height; CESC cis rs11252926 0.673 rs7096559 chr10:499188 C/T cg18196295 chr10:418757 DIP2C 0.5 6.79 0.38 7.44e-11 Psychosis in Alzheimer's disease; CESC cis rs611744 0.625 rs4735055 chr8:109286642 G/A cg21045802 chr8:109455806 TTC35 0.48 5.87 0.34 1.29e-8 Dupuytren's disease; CESC cis rs17376456 0.877 rs10476601 chr5:93402522 G/A cg21475434 chr5:93447410 FAM172A 0.82 7.28 0.41 3.91e-12 Diabetic retinopathy; CESC cis rs5758659 0.714 rs5751216 chr22:42508937 G/T cg15557168 chr22:42548783 NA 0.42 6.46 0.37 4.94e-10 Cognitive function; CESC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg06481639 chr22:41940642 POLR3H -0.63 -6.54 -0.37 3.09e-10 Vitiligo; CESC cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg08917208 chr2:24149416 ATAD2B 0.62 5.98 0.34 7.28e-9 Lymphocyte counts; CESC cis rs2758596 0.850 rs2842879 chr1:156163695 G/T cg25208724 chr1:156163844 SLC25A44 0.65 6.24 0.36 1.72e-9 Paclitaxel disposition in epithelial ovarian cancer; CESC cis rs17401966 0.931 rs4846205 chr1:10310214 A/T cg15208524 chr1:10270712 KIF1B 0.41 5.25 0.31 3.14e-7 Hepatocellular carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00703902 chr7:5253016 WIPI2 0.52 6.04 0.35 5.21e-9 Gut microbiome composition (summer); CESC cis rs1018836 0.599 rs9643295 chr8:91492283 T/G cg16814680 chr8:91681699 NA -0.55 -7.75 -0.43 1.91e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs873946 0.586 rs12767391 chr10:134573844 A/G cg18305652 chr10:134549665 INPP5A -0.42 -6.03 -0.35 5.43e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6594499 0.872 rs10038177 chr5:110436450 C/T cg04022379 chr5:110408740 TSLP 0.34 6.22 0.36 1.9e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs9811920 0.609 rs10936005 chr3:99674093 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.6 -9.71 -0.51 2.92e-19 Axial length; CESC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg12564285 chr5:131593104 PDLIM4 0.4 6.13 0.35 3.15e-9 Breast cancer; CESC cis rs3806843 1.000 rs2337985 chr5:140157861 T/C cg26395211 chr5:140044315 WDR55 -0.42 -5.41 -0.32 1.41e-7 Depressive symptoms (multi-trait analysis); CESC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.49 0.42 1.05e-12 Height; CESC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg14893161 chr1:205819251 PM20D1 -0.42 -5.83 -0.34 1.64e-8 Parkinson's disease; CESC cis rs11252926 0.589 rs12359901 chr10:475068 A/G cg16386425 chr10:429943 DIP2C 0.48 5.99 0.35 6.99e-9 Psychosis in Alzheimer's disease; CESC cis rs7829975 0.777 rs560544 chr8:8637429 G/A cg15556689 chr8:8085844 FLJ10661 -0.45 -5.68 -0.33 3.53e-8 Mood instability; CESC cis rs9863 0.828 rs12833624 chr12:124476873 C/T cg00084347 chr12:124393913 DNAH10 0.26 5.06 0.3 7.9e-7 White blood cell count; CESC cis rs7666738 0.800 rs2865988 chr4:99067807 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.5 0.46 1.41e-15 Colonoscopy-negative controls vs population controls; CESC cis rs897984 0.806 rs11640534 chr16:30949515 G/A cg02466173 chr16:30829666 NA 0.48 8.19 0.45 1.15e-14 Dementia with Lewy bodies; CESC trans rs7246760 0.867 rs67539464 chr19:9832424 C/G cg02900749 chr2:68251473 NA -0.8 -7.31 -0.41 3.22e-12 Pursuit maintenance gain; CESC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.47 6.08 0.35 4.06e-9 Tonsillectomy; CESC cis rs3125734 0.660 rs10733769 chr10:63974255 G/T cg09941381 chr10:64027924 RTKN2 -0.32 -5.17 -0.3 4.51e-7 Rheumatoid arthritis; CESC cis rs7843479 0.506 rs7818430 chr8:21798429 C/T cg17168535 chr8:21777572 XPO7 0.76 12.74 0.62 2.53e-29 Mean corpuscular volume; CESC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8044868 0.512 rs10048144 chr16:72052891 C/G cg16558253 chr16:72132732 DHX38 -0.37 -5.69 -0.33 3.31e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs2354432 0.607 rs11239980 chr1:146782698 G/A cg25205988 chr1:146714368 CHD1L -1.0 -8.9 -0.48 9.01e-17 Mitochondrial DNA levels; CESC cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg04455712 chr21:45112962 RRP1B 0.51 7.8 0.43 1.44e-13 Mean corpuscular volume; CESC trans rs17685 0.753 rs10233282 chr7:75790081 C/T cg19862616 chr7:65841803 NCRNA00174 0.84 12.03 0.59 6.77e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2760061 0.598 rs1774755 chr1:228115282 T/G cg02753203 chr1:228287806 NA -0.5 -7.24 -0.41 4.83e-12 Diastolic blood pressure; CESC cis rs6964587 0.626 rs68009402 chr7:91516226 G/A cg17063962 chr7:91808500 NA -0.46 -6.48 -0.37 4.5e-10 Breast cancer; CESC cis rs72634258 0.945 rs225120 chr1:8046378 C/T cg00042356 chr1:8021962 PARK7 0.59 6.3 0.36 1.25e-9 Inflammatory bowel disease; CESC cis rs921968 0.643 rs864990 chr2:219494037 G/A cg02176678 chr2:219576539 TTLL4 0.39 6.64 0.38 1.79e-10 Mean corpuscular hemoglobin concentration; CESC cis rs11122272 0.735 rs2437149 chr1:231490105 C/T cg06096015 chr1:231504339 EGLN1 0.42 6.12 0.35 3.3e-9 Hemoglobin concentration; CESC cis rs6429082 0.875 rs2291688 chr1:235594250 A/G cg26050004 chr1:235667680 B3GALNT2 -0.41 -5.29 -0.31 2.51e-7 Adiposity; CESC cis rs4234798 0.500 rs7661066 chr4:7219878 C/T cg18431297 chr4:7219810 SORCS2 0.56 9.37 0.5 3.28e-18 Insulin-like growth factors; CESC trans rs35110281 0.627 rs6518268 chr21:44967448 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 7.52 0.42 8.61e-13 Mean corpuscular volume; CESC cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg04455712 chr21:45112962 RRP1B 0.47 7.61 0.42 4.67e-13 Mean corpuscular volume; CESC cis rs3825932 0.736 rs1036939 chr15:79237324 C/A cg25744700 chr15:79237217 CTSH 0.48 6.35 0.36 9.31e-10 Type 1 diabetes; CESC cis rs4642101 0.640 rs9877049 chr3:12821231 A/G cg05775895 chr3:12838266 CAND2 0.41 6.3 0.36 1.23e-9 QRS complex (12-leadsum); CESC cis rs1950626 0.750 rs72700530 chr14:101429459 G/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.82 11.2 0.57 4.23e-24 Pelvic organ prolapse (moderate/severe); CESC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg18876405 chr7:65276391 NA 0.51 6.68 0.38 1.39e-10 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17249942 chr21:45660288 ICOSLG -0.48 -6.27 -0.36 1.42e-9 Fibrinogen levels; CESC trans rs11971186 0.924 rs3919444 chr7:126473588 C/T cg10894441 chr11:111169905 C11orf92;C11orf93 -0.46 -6.0 -0.35 6.57e-9 Chemerin levels; CESC cis rs9467711 0.606 rs67234939 chr6:26530419 A/G cg12826209 chr6:26865740 GUSBL1 0.59 5.27 0.31 2.84e-7 Autism spectrum disorder or schizophrenia; CESC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg21280719 chr6:42927975 GNMT -0.3 -7.06 -0.4 1.44e-11 Alzheimer's disease in APOE e4+ carriers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10066545 chr7:66072065 NA -0.48 -6.01 -0.35 6e-9 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs3008854 chr1:67385951 T/C cg02640540 chr1:67518911 SLC35D1 0.48 5.19 0.3 4.09e-7 Lymphocyte percentage of white cells; CESC cis rs7095944 0.585 rs11245357 chr10:126452042 A/G cg08799069 chr10:126477246 METTL10 -0.35 -5.14 -0.3 5.46e-7 Asthma; CESC cis rs7219021 0.961 rs9906942 chr17:46864634 G/A cg16584676 chr17:46985605 UBE2Z -0.56 -6.31 -0.36 1.14e-9 Schizophrenia or bipolar disorder; CESC cis rs5167 0.506 rs11669173 chr19:45492559 G/A cg13119609 chr19:45449297 APOC2 -0.51 -7.69 -0.43 2.89e-13 Blood protein levels; CESC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg23048001 chr7:2026167 MAD1L1 0.44 5.73 0.33 2.73e-8 Bipolar disorder and schizophrenia; CESC cis rs1348850 0.914 rs4893950 chr2:178304885 T/C cg23306229 chr2:178417860 TTC30B 0.64 7.97 0.44 4.59e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs7914558 0.966 rs11191438 chr10:104637864 C/G cg08650961 chr10:104748594 CNNM2 0.35 5.87 0.34 1.27e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2243480 1.000 rs313809 chr7:65499983 G/A cg13147721 chr7:65941812 NA -0.91 -8.69 -0.47 3.87e-16 Diabetic kidney disease; CESC cis rs477895 1.000 rs477895 chr11:64048912 C/T cg04317338 chr11:64019027 PLCB3 -0.52 -5.07 -0.3 7.4e-7 Mean platelet volume; CESC cis rs2066819 1.000 rs2066819 chr12:56750204 C/T cg26714650 chr12:56694279 CS -1.39 -9.06 -0.49 2.88e-17 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07264050 chr8:48920858 UBE2V2 0.63 7.58 0.42 5.75e-13 Gut microbiome composition (summer); CESC cis rs6502050 0.842 rs7211808 chr17:80071244 T/C cg23985595 chr17:80112537 CCDC57 0.4 6.35 0.36 9.15e-10 Life satisfaction; CESC cis rs2742234 0.955 rs2503841 chr10:43675721 C/T cg07801480 chr10:43725741 RASGEF1A 0.39 5.69 0.33 3.31e-8 Hirschsprung disease; CESC cis rs12586317 0.557 rs8004288 chr14:35679288 A/G cg16230307 chr14:35515116 FAM177A1 0.42 5.22 0.31 3.57e-7 Psoriasis; CESC trans rs17508449 0.819 rs4839331 chr1:114161631 A/G cg23028848 chr11:57092561 TNKS1BP1 -0.74 -6.0 -0.35 6.52e-9 Leprosy; CESC cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs7839040 0.698 rs13277577 chr8:82931310 C/T cg14472086 chr9:107730925 NA -0.48 -6.45 -0.37 5.4e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs3857067 0.806 rs12513267 chr4:95109545 C/T cg11021082 chr4:95130006 SMARCAD1 -0.59 -8.92 -0.48 7.87e-17 QT interval; CESC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg20243544 chr17:37824526 PNMT 0.51 6.4 0.37 6.86e-10 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.28 0.31 2.64e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3796392 1 rs3796392 chr3:129137127 G/A cg18113058 chr3:129116479 RPL32P3;SNORA7B 1.12 5.99 0.35 6.85e-9 Diisocyanate-induced asthma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06066128 chr3:47018377 CCDC12 -0.49 -6.13 -0.35 3.22e-9 Gut microbiota (bacterial taxa); CESC cis rs6430585 0.702 rs2304601 chr2:136528034 C/A cg07169764 chr2:136633963 MCM6 1.26 16.5 0.71 1.45e-42 Corneal structure; CESC cis rs6728642 0.614 rs113485946 chr2:97866442 T/C cg26665480 chr2:98280029 ACTR1B -0.92 -6.97 -0.39 2.47e-11 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs6964587 1.000 rs756647 chr7:91586389 A/G cg17063962 chr7:91808500 NA 0.58 7.89 0.44 7.72e-14 Breast cancer; CESC cis rs3820928 0.874 rs4234063 chr2:227828335 A/T cg11843606 chr2:227700838 RHBDD1 0.47 6.11 0.35 3.58e-9 Pulmonary function; CESC cis rs66573146 0.572 rs66734745 chr4:6948765 T/C cg00086871 chr4:6988644 TBC1D14 1.03 6.85 0.39 5.16e-11 Granulocyte percentage of myeloid white cells; CESC cis rs7917772 0.536 rs12357172 chr10:104388549 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.51 5.47 0.32 1.06e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -5.13 -0.3 5.63e-7 Developmental language disorder (linguistic errors); CESC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg03538708 chr1:25844672 NA -0.35 -5.21 -0.3 3.85e-7 Plateletcrit;Mean corpuscular volume; CESC cis rs7772486 0.654 rs6928007 chr6:146074941 G/A cg23711669 chr6:146136114 FBXO30 -0.87 -12.87 -0.62 8.94e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg05347473 chr6:146136440 FBXO30 0.59 7.78 0.43 1.59e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs17666538 0.591 rs2878547 chr8:603416 G/A cg07685180 chr8:600429 NA 0.6 5.13 0.3 5.73e-7 IgG glycosylation; CESC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg18357526 chr6:26021779 HIST1H4A -0.61 -8.53 -0.46 1.13e-15 Intelligence (multi-trait analysis); CESC cis rs9291683 0.588 rs12506364 chr4:10023448 C/T cg02734326 chr4:10020555 SLC2A9 0.48 6.9 0.39 3.89e-11 Bone mineral density; CESC cis rs4925386 1.000 rs4925386 chr20:60921044 C/T cg22633769 chr20:60982531 CABLES2 0.42 5.07 0.3 7.46e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg22968622 chr17:43663579 NA -1.19 -16.0 -0.7 8.93e-41 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.72 0.33 2.9e-8 Personality dimensions; CESC trans rs9929218 0.551 rs3785133 chr16:68728611 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.89 14.92 0.68 5.68e-37 Colorectal cancer; CESC cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg14416269 chr4:6271139 WFS1 0.47 7.54 0.42 7.67e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6963495 0.818 rs6944787 chr7:105147309 C/T cg19920283 chr7:105172520 RINT1 0.66 6.28 0.36 1.36e-9 Bipolar disorder (body mass index interaction); CESC trans rs7944735 0.767 rs1017875 chr11:47999218 C/T cg15704280 chr7:45808275 SEPT13 0.59 6.16 0.35 2.74e-9 Intraocular pressure; CESC cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.35 0.46 3.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6456156 0.586 rs12213801 chr6:167474084 T/A cg07741184 chr6:167504864 NA 0.37 6.39 0.37 7.28e-10 Primary biliary cholangitis; CESC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg24768116 chr2:27665128 KRTCAP3 -0.31 -5.62 -0.33 4.71e-8 Total body bone mineral density; CESC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.56 7.85 0.43 1.05e-13 Bipolar disorder; CESC cis rs9929218 0.529 rs2296404 chr16:68729525 C/T cg01251360 chr16:68772225 CDH1 -0.23 -5.12 -0.3 6.01e-7 Colorectal cancer; CESC cis rs6540556 0.608 rs7532324 chr1:209918090 C/T cg05527609 chr1:210001259 C1orf107 -0.58 -6.93 -0.39 3.18e-11 Red blood cell count; CESC cis rs1707322 0.691 rs61784799 chr1:46177748 A/G cg06784218 chr1:46089804 CCDC17 -0.41 -7.21 -0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg08859206 chr1:53392774 SCP2 -0.64 -8.62 -0.47 6.22e-16 Monocyte count; CESC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11166348 chr1:7740267 CAMTA1 0.51 6.09 0.35 3.95e-9 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.14 -0.3 5.22e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg17372223 chr3:52568218 NT5DC2 0.4 5.93 0.34 9.47e-9 Electroencephalogram traits; CESC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.34 5.78 0.33 2.1e-8 Bipolar disorder; CESC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg23283495 chr1:209979779 IRF6 -0.49 -6.06 -0.35 4.54e-9 Cleft lip with or without cleft palate; CESC cis rs7680126 0.632 rs6834645 chr4:10150174 G/A cg00071950 chr4:10020882 SLC2A9 -0.61 -6.53 -0.37 3.41e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs7615952 0.611 rs2947646 chr3:125593602 C/T cg07211511 chr3:129823064 LOC729375 0.8 7.66 0.43 3.46e-13 Blood pressure (smoking interaction); CESC cis rs7692995 1.000 rs6840868 chr4:17939331 C/T cg08925142 chr4:18023851 LCORL -0.45 -5.28 -0.31 2.65e-7 Height; CESC cis rs868036 1.000 rs1026732 chr15:68095085 C/T cg08079166 chr15:68083412 MAP2K5 0.44 7.06 0.4 1.5e-11 Restless legs syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09567311 chr17:53316197 NA -0.54 -6.42 -0.37 6.39e-10 Gut microbiome composition (summer); CESC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg21251018 chr6:28226885 NKAPL 0.35 5.29 0.31 2.57e-7 Depression; CESC cis rs1348850 0.872 rs4893825 chr2:178298687 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.77 10.18 0.53 9.32e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9834373 0.853 rs13322529 chr3:78495795 A/G cg06138941 chr3:78371609 NA -0.42 -5.12 -0.3 5.77e-7 Protein quantitative trait loci; CESC cis rs17209837 0.607 rs60040620 chr7:87085379 C/A cg00919237 chr7:87102261 ABCB4 -0.51 -6.58 -0.37 2.45e-10 Gallbladder cancer; CESC cis rs35110281 0.840 rs7276633 chr21:45078800 C/T cg01579765 chr21:45077557 HSF2BP -0.58 -9.91 -0.52 6.67e-20 Mean corpuscular volume; CESC cis rs2180341 0.781 rs7760652 chr6:127572096 A/G cg27446573 chr6:127587934 RNF146 0.83 11.71 0.58 8.67e-26 Breast cancer; CESC trans rs7840128 1.000 rs2720743 chr8:3677684 C/T cg00270497 chr6:84562908 RIPPLY2 -0.79 -6.58 -0.37 2.44e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg13770153 chr20:60521292 NA -0.44 -5.68 -0.33 3.6e-8 Body mass index; CESC cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg13298116 chr11:62369859 EML3;MTA2 0.64 9.47 0.5 1.65e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.76 -0.33 2.37e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg21951975 chr1:209979733 IRF6 0.6 9.37 0.5 3.31e-18 Cleft lip with or without cleft palate; CESC cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.1e-7 Colonoscopy-negative controls vs population controls; CESC cis rs67478160 0.654 rs11628240 chr14:104218135 A/G cg08213375 chr14:104286397 PPP1R13B 0.55 11.04 0.56 1.4e-23 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22717323 chr7:2094977 MAD1L1 0.4 6.2 0.36 2.17e-9 Fibrinogen levels; CESC cis rs2540647 0.706 rs2518804 chr22:18975504 A/C cg12798833 chr22:18958832 DGCR5 0.5 5.45 0.32 1.15e-7 Blood metabolite ratios; CESC trans rs9467711 0.790 rs1979 chr6:26377591 G/T cg06606381 chr12:133084897 FBRSL1 -0.74 -6.73 -0.38 1.05e-10 Autism spectrum disorder or schizophrenia; CESC cis rs3780486 0.846 rs10738905 chr9:33123627 A/G cg13443165 chr9:33130375 B4GALT1 0.43 6.23 0.36 1.86e-9 IgG glycosylation; CESC cis rs897080 0.552 rs1067377 chr2:44648239 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs6963495 0.615 rs2697021 chr7:105151029 A/C cg13798780 chr7:105162888 PUS7 0.5 6.09 0.35 4.04e-9 Bipolar disorder (body mass index interaction); CESC cis rs1003719 0.788 rs2835600 chr21:38468958 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs7927771 1.000 rs12787330 chr11:47812311 C/T cg05585544 chr11:47624801 NA -0.49 -7.71 -0.43 2.62e-13 Subjective well-being; CESC cis rs11077998 0.967 rs4789788 chr17:80510285 C/T cg10255544 chr17:80519551 FOXK2 -0.52 -8.56 -0.47 9.1e-16 Reticulocyte fraction of red cells; CESC cis rs9837602 1.000 rs6799379 chr3:99762840 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 7.14 0.4 8.96e-12 Breast cancer; CESC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs6460942 1.000 rs112794590 chr7:12319426 G/A cg02935154 chr7:12443704 VWDE -0.59 -5.84 -0.34 1.5e-8 Coronary artery disease; CESC cis rs854765 0.693 rs8079418 chr17:17924060 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.4 5.58 0.32 5.93e-8 Total body bone mineral density; CESC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg17143192 chr8:8559678 CLDN23 0.66 7.49 0.42 1.01e-12 Obesity-related traits; CESC cis rs12681366 0.537 rs2919664 chr8:95468713 A/G cg13257157 chr8:95487014 RAD54B 0.45 5.47 0.32 1.02e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs710216 0.917 rs900837 chr1:43412793 A/G cg03128534 chr1:43423976 SLC2A1 -0.56 -6.49 -0.37 4.09e-10 Red cell distribution width; CESC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg09658497 chr7:2847517 GNA12 -0.43 -5.93 -0.34 9.31e-9 Height; CESC trans rs2018683 1.000 rs740252 chr7:28997765 C/G cg19402173 chr7:128379420 CALU -0.66 -8.73 -0.47 2.87e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs7937682 0.961 rs491937 chr11:111494947 A/T cg09085632 chr11:111637200 PPP2R1B -0.91 -13.98 -0.65 1.22e-33 Primary sclerosing cholangitis; CESC cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg23649088 chr2:200775458 C2orf69 0.72 8.93 0.48 7.24e-17 Osteoporosis; CESC cis rs7084402 0.967 rs1658427 chr10:60331504 G/A cg07615347 chr10:60278583 BICC1 0.59 9.22 0.49 9.62e-18 Refractive error; CESC cis rs9314323 0.798 rs2019239 chr8:26217354 G/A cg11498726 chr8:26250323 BNIP3L -0.44 -6.47 -0.37 4.7e-10 Red cell distribution width; CESC cis rs6893300 0.524 rs12522926 chr5:179214818 G/A cg14593053 chr5:179126677 CANX 0.53 7.87 0.44 8.9e-14 Resting heart rate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12977448 chr10:14920832 SUV39H2 -0.42 -6.1 -0.35 3.79e-9 Gambling; CESC cis rs568617 1.000 rs687672 chr11:65649984 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.67 -7.06 -0.4 1.43e-11 Crohn's disease; CESC cis rs7666738 0.830 rs7659593 chr4:98934823 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2932538 0.922 rs6668533 chr1:113064468 C/T cg22162597 chr1:113214053 CAPZA1 0.55 6.83 0.39 5.8e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs4969178 0.965 rs56658017 chr17:76396164 G/A cg05887092 chr17:76393375 PGS1 0.58 9.22 0.49 9.9e-18 HDL cholesterol levels; CESC trans rs11096990 0.964 rs6831700 chr4:39256964 G/T cg24474409 chr7:150021518 ACTR3C;LRRC61 -0.38 -6.05 -0.35 4.89e-9 Cognitive function; CESC cis rs2404602 0.692 rs12437733 chr15:77155562 A/G cg26408565 chr15:76604113 ETFA -0.39 -5.68 -0.33 3.6e-8 Blood metabolite levels; CESC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.13 -0.35 3.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7945705 0.791 rs6484484 chr11:8817206 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.33 5.16 0.3 4.93e-7 Hemoglobin concentration; CESC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg17328964 chr8:145687451 CYHR1 -0.57 -7.72 -0.43 2.34e-13 Age at first birth; CESC trans rs17716202 0.702 rs16885766 chr5:55892229 A/G cg14306956 chr9:37027384 PAX5 -0.53 -6.02 -0.35 5.7e-9 Psychosis in Alzheimer's disease; CESC cis rs694739 0.796 rs479777 chr11:64107477 A/G cg23796481 chr11:64053134 BAD;GPR137 0.67 8.37 0.46 3.26e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs1620921 0.505 rs2115870 chr6:161207992 A/G cg01280913 chr6:161186852 NA -0.38 -5.69 -0.33 3.37e-8 Lipoprotein (a) - cholesterol levels; CESC cis rs17431357 1.000 rs76230314 chr12:120930908 C/T cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs902774 0.515 rs2363635 chr12:53354622 T/C cg05393297 chr12:53359155 NA -0.63 -8.77 -0.47 2.24e-16 Prostate cancer; CESC cis rs9467711 0.606 rs9358930 chr6:26357011 C/T cg14345882 chr6:26364793 BTN3A2 0.59 6.06 0.35 4.66e-9 Autism spectrum disorder or schizophrenia; CESC cis rs698833 0.828 rs2165421 chr2:44526010 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 6.1 0.35 3.79e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9831754 1.000 rs9855903 chr3:78347988 C/A cg06138941 chr3:78371609 NA -0.78 -8.75 -0.47 2.54e-16 Calcium levels; CESC cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.84 13.65 0.64 1.68e-32 Hip circumference adjusted for BMI; CESC cis rs10823500 0.604 rs10762345 chr10:71939374 A/G cg04118878 chr10:71993077 PPA1 0.43 5.13 0.3 5.55e-7 Blood protein levels; CESC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs919433 0.857 rs36071109 chr2:198183191 C/A cg03934865 chr2:198174659 NA -0.42 -5.83 -0.34 1.57e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs10504229 0.679 rs10504217 chr8:58037522 A/G cg22535103 chr8:58192502 C8orf71 -0.6 -6.76 -0.38 8.68e-11 Developmental language disorder (linguistic errors); CESC trans rs2502399 0.652 rs1321021 chr6:113505786 T/C cg00285294 chr7:1089767 C7orf50 -0.35 -6.31 -0.36 1.14e-9 Plasma clusterin levels; CESC cis rs6831352 0.918 rs13138294 chr4:100062675 T/G cg12011299 chr4:100065546 ADH4 -0.6 -6.7 -0.38 1.25e-10 Alcohol dependence; CESC cis rs8072100 0.701 rs6503807 chr17:45772932 T/C cg08085267 chr17:45401833 C17orf57 -0.43 -5.45 -0.32 1.12e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs12586317 0.547 rs116499019 chr14:35441931 T/C cg05294307 chr14:35346193 BAZ1A -0.49 -5.37 -0.31 1.75e-7 Psoriasis; CESC cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg05340658 chr4:99064831 C4orf37 0.76 11.21 0.57 4.1e-24 Colonoscopy-negative controls vs population controls; CESC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg17724175 chr1:150552817 MCL1 0.45 7.33 0.41 2.84e-12 Melanoma; CESC cis rs9549367 0.737 rs71446680 chr13:113894846 C/T cg18105134 chr13:113819100 PROZ -0.71 -8.63 -0.47 5.81e-16 Platelet distribution width; CESC cis rs12541635 0.934 rs7008840 chr8:107016404 T/C cg10147462 chr8:107024639 NA 0.42 5.87 0.34 1.31e-8 Age of smoking initiation; CESC cis rs12410462 0.892 rs35341041 chr1:227653885 G/A cg23173402 chr1:227635558 NA 0.55 5.41 0.32 1.41e-7 Major depressive disorder; CESC cis rs6456156 0.586 rs1358882 chr6:167467101 G/A cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.13e-10 Primary biliary cholangitis; CESC cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg02551604 chr5:131831745 NA -0.37 -5.27 -0.31 2.81e-7 Asthma (sex interaction); CESC cis rs10198628 0.623 rs779339 chr2:13043884 A/G cg13769605 chr2:12857067 TRIB2 0.42 5.83 0.34 1.65e-8 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg25072359 chr17:41440525 NA 0.46 6.06 0.35 4.72e-9 Menopause (age at onset); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg16157530 chr2:105654526 MRPS9 0.43 6.05 0.35 4.91e-9 Vertical cup-disc ratio; CESC cis rs9910055 0.530 rs7222349 chr17:42304644 C/T cg19774624 chr17:42201019 HDAC5 -0.6 -8.52 -0.46 1.24e-15 Total body bone mineral density; CESC cis rs734999 0.566 rs12748729 chr1:2558740 C/T cg20673091 chr1:2541236 MMEL1 -0.48 -8.01 -0.44 3.71e-14 Ulcerative colitis; CESC cis rs892961 0.932 rs3987886 chr17:75414980 A/G cg05865280 chr17:75406074 SEPT9 0.63 12.78 0.62 1.79e-29 Airflow obstruction; CESC cis rs4975616 0.686 rs37008 chr5:1351538 C/T cg26373071 chr5:1325741 CLPTM1L 0.42 6.77 0.38 8.03e-11 Lung cancer; CESC cis rs921968 0.541 rs6720403 chr2:219294258 A/C cg02176678 chr2:219576539 TTLL4 -0.48 -8.4 -0.46 2.8e-15 Mean corpuscular hemoglobin concentration; CESC trans rs57221529 0.545 rs55955015 chr5:575182 A/G cg25482853 chr8:67687455 SGK3 1.01 10.19 0.53 8.63e-21 Lung disease severity in cystic fibrosis; CESC cis rs4654899 1.000 rs4654905 chr1:21509558 A/G cg05370193 chr1:21551575 ECE1 0.41 6.22 0.36 1.96e-9 Superior frontal gyrus grey matter volume; CESC cis rs2404602 0.684 rs28895952 chr15:76856776 A/G cg23625390 chr15:77176239 SCAPER -0.44 -6.13 -0.35 3.24e-9 Blood metabolite levels; CESC cis rs3796619 1.000 rs4974601 chr4:1095410 G/A cg27284194 chr4:1044797 NA 0.38 5.74 0.33 2.58e-8 Recombination rate (males); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg09196456 chr19:1390694 NDUFS7 0.43 6.17 0.35 2.6e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11190604 1.000 rs7088512 chr10:102303498 G/T cg07080220 chr10:102295463 HIF1AN 0.56 5.42 0.32 1.35e-7 Palmitoleic acid (16:1n-7) levels; CESC trans rs7741085 0.872 rs11755164 chr6:44639184 A/G cg04735960 chr13:21006388 CRYL1 -0.45 -6.13 -0.35 3.18e-9 Total body bone mineral density; CESC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 11.93 0.59 1.55e-26 Platelet count; CESC cis rs7000551 0.725 rs2469757 chr8:22360938 C/T cg12081754 chr8:22256438 SLC39A14 0.39 5.31 0.31 2.33e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs60154123 0.505 rs76101197 chr1:210044089 T/C cg23283495 chr1:209979779 IRF6 0.53 5.68 0.33 3.56e-8 Coronary artery disease; CESC cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg20503657 chr10:835505 NA 0.77 8.0 0.44 3.93e-14 Eosinophil percentage of granulocytes; CESC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg27572855 chr1:25598939 RHD 0.5 8.4 0.46 2.68e-15 Plateletcrit;Mean corpuscular volume; CESC cis rs55882075 0.535 rs67484565 chr5:179110574 G/T cg14593053 chr5:179126677 CANX 0.46 5.91 0.34 1.07e-8 Monocyte percentage of white cells; CESC cis rs1801251 0.778 rs2250665 chr2:233752639 A/T cg08000102 chr2:233561755 GIGYF2 -0.57 -7.79 -0.43 1.52e-13 Coronary artery disease; CESC cis rs7149337 0.717 rs4309324 chr14:51606336 A/T cg23942311 chr14:51606299 NA -0.55 -9.72 -0.51 2.68e-19 Cancer; CESC cis rs3770081 1.000 rs6724025 chr2:86200835 A/G cg01119172 chr2:86362222 SNORD94;PTCD3 0.65 5.11 0.3 6.12e-7 Facial emotion recognition (sad faces); CESC cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg00255919 chr5:131827918 IRF1 0.51 8.68 0.47 4.19e-16 Asthma (sex interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02674305 chr20:34359915 PHF20 -0.69 -8.71 -0.47 3.44e-16 Gut microbiome composition (summer); CESC cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.81 0.34 1.8e-8 Tonsillectomy; CESC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg13206674 chr6:150067644 NUP43 0.4 5.57 0.32 6.36e-8 Lung cancer; CESC cis rs4481887 0.893 rs4297335 chr1:248473421 C/T cg00666640 chr1:248458726 OR2T12 0.36 6.12 0.35 3.33e-9 Common traits (Other); CESC cis rs9611519 0.580 rs8138349 chr22:41412723 C/T cg03806693 chr22:41940476 POLR3H -0.51 -6.04 -0.35 5.18e-9 Neuroticism; CESC cis rs7582720 0.943 rs72932560 chr2:203847417 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg07157834 chr1:205819609 PM20D1 0.7 10.74 0.55 1.37e-22 Menarche (age at onset); CESC trans rs3087243 0.755 rs3115969 chr2:204694805 T/C cg01841312 chr10:38069945 NA 0.38 6.33 0.36 1.03e-9 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs6714710 0.603 rs34974566 chr2:98552299 C/G cg26665480 chr2:98280029 ACTR1B 0.58 7.99 0.44 4.15e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Tonsillectomy; CESC cis rs2180341 0.961 rs7775493 chr6:127615000 C/A cg27446573 chr6:127587934 RNF146 1.08 16.13 0.7 3.14e-41 Breast cancer; CESC cis rs854765 0.583 rs4244602 chr17:17841456 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.38 0.37 7.73e-10 Total body bone mineral density; CESC cis rs7945705 0.967 rs10769973 chr11:8928615 C/G cg12365402 chr11:9010492 NRIP3 0.4 6.09 0.35 3.86e-9 Hemoglobin concentration; CESC cis rs950169 0.920 rs12915390 chr15:84792069 T/C cg17507749 chr15:85114479 UBE2QP1 0.62 6.89 0.39 4e-11 Schizophrenia; CESC cis rs6674176 0.660 rs12726706 chr1:44399942 G/A cg23954153 chr1:44402353 ARTN -0.35 -5.51 -0.32 8.56e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs921968 0.565 rs6723334 chr2:219629303 C/T cg02176678 chr2:219576539 TTLL4 0.42 7.5 0.42 9.58e-13 Mean corpuscular hemoglobin concentration; CESC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg08736216 chr1:53307985 ZYG11A 0.35 6.25 0.36 1.65e-9 Monocyte count; CESC cis rs9902453 0.791 rs2628166 chr17:28113123 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -8.47 -0.46 1.74e-15 Coffee consumption (cups per day); CESC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg15445000 chr17:37608096 MED1 -0.4 -6.38 -0.36 7.99e-10 Glomerular filtration rate (creatinine); CESC cis rs3857067 0.773 rs10023115 chr4:95095502 G/A cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.04 -0.49 3.47e-17 QT interval; CESC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg22823121 chr1:150693482 HORMAD1 0.45 6.38 0.36 7.78e-10 Melanoma; CESC cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg03433033 chr1:76189801 ACADM 0.63 6.35 0.36 9.5e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9447004 0.557 rs2173854 chr6:74426775 T/A cg23004174 chr6:74404879 CD109 0.35 5.07 0.3 7.63e-7 Blood protein levels;Calcium levels; CESC cis rs2806561 0.894 rs1738475 chr1:23536891 C/G cg12483005 chr1:23474871 LUZP1 0.32 5.15 0.3 4.99e-7 Height; CESC cis rs6570726 0.935 rs372378 chr6:145816227 A/G cg23711669 chr6:146136114 FBXO30 0.82 12.29 0.6 8.74e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg17372223 chr3:52568218 NT5DC2 0.41 6.32 0.36 1.11e-9 Bipolar disorder; CESC cis rs9443189 0.570 rs659807 chr6:76293435 C/A cg01950844 chr6:76311363 SENP6 0.87 9.54 0.51 9.61e-19 Prostate cancer; CESC cis rs7089973 0.624 rs11196940 chr10:116593791 T/G cg25233709 chr10:116636983 FAM160B1 0.39 6.13 0.35 3.22e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18073432 chr5:86180679 NA -0.56 -6.78 -0.38 7.68e-11 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs4660328 chr1:46444831 G/T cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg17971929 chr21:40555470 PSMG1 -0.59 -7.65 -0.43 3.67e-13 Menarche (age at onset); CESC cis rs8180040 1.000 rs295458 chr3:47385585 C/A cg27129171 chr3:47204927 SETD2 0.66 10.0 0.52 3.6e-20 Colorectal cancer; CESC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg26338869 chr17:61819248 STRADA 0.69 8.69 0.47 3.91e-16 Prudent dietary pattern; CESC cis rs9910055 0.659 rs112114764 chr17:42201041 G/T cg19774624 chr17:42201019 HDAC5 0.9 14.87 0.67 8.64e-37 Total body bone mineral density; CESC cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg13877915 chr19:58951672 ZNF132 0.37 5.53 0.32 7.56e-8 Uric acid clearance; CESC cis rs3784262 1.000 rs4646627 chr15:58255305 A/G cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.13 -0.3 5.51e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs735396 0.770 rs1169300 chr12:121431225 G/A cg25281562 chr12:121454272 C12orf43 0.53 6.68 0.38 1.43e-10 N-glycan levels; CESC cis rs10206020 0.879 rs72778007 chr2:1573178 C/T cg12573674 chr2:1569213 NA -0.47 -5.42 -0.32 1.33e-7 IgG glycosylation; CESC cis rs4722166 0.630 rs2091115 chr7:22810166 G/T cg13104385 chr7:22767384 IL6 0.41 5.56 0.32 6.6e-8 Lung cancer; CESC trans rs6456042 0.893 rs3099312 chr6:166557339 T/C cg01261503 chr17:62493599 POLG2 -0.44 -6.3 -0.36 1.2e-9 Asthma; CESC cis rs3916 0.911 rs3999408 chr12:121167387 C/T cg21892295 chr12:121157589 UNC119B -0.36 -5.24 -0.31 3.35e-7 Urinary metabolites (H-NMR features); CESC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg11764359 chr7:65958608 NA 0.96 15.23 0.68 4.87e-38 Aortic root size; CESC cis rs2230307 0.536 rs2893426 chr1:100528200 G/T cg24955406 chr1:100503596 HIAT1 0.55 5.37 0.31 1.76e-7 Carotid intima media thickness; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg17670436 chr10:3374199 NA -0.45 -6.19 -0.36 2.23e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2274273 1.000 rs67098772 chr14:55595242 G/A cg04306507 chr14:55594613 LGALS3 0.28 5.15 0.3 5.13e-7 Protein biomarker; CESC cis rs694739 0.796 rs479777 chr11:64107477 A/G cg02228329 chr11:64053129 BAD;GPR137 0.72 9.32 0.5 4.74e-18 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs9914266 1 rs9914266 chr17:2133250 T/C cg16513277 chr17:2031491 SMG6 -0.63 -8.99 -0.48 4.73e-17 Myocardial infarction; CESC cis rs933688 1.000 rs7720132 chr5:90745105 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 11.04 0.56 1.47e-23 Smoking behavior; CESC cis rs1008375 1.000 rs10939756 chr4:17693867 C/T cg16339924 chr4:17578868 LAP3 0.58 7.22 0.41 5.37e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6570726 0.846 rs453834 chr6:145886261 T/C cg23711669 chr6:146136114 FBXO30 0.85 13.03 0.62 2.59e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs113835537 0.529 rs117112180 chr11:66293273 A/G cg24851651 chr11:66362959 CCS 0.53 6.07 0.35 4.43e-9 Airway imaging phenotypes; CESC cis rs6662572 1.000 rs56251392 chr1:46210829 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 5.55 0.32 7.08e-8 Blood protein levels; CESC trans rs11148252 0.595 rs9526974 chr13:53251040 C/G cg18335740 chr13:41363409 SLC25A15 0.51 6.83 0.39 5.79e-11 Lewy body disease; CESC cis rs2014572 0.967 rs10411941 chr19:57762886 C/T cg12963866 chr19:57752005 ZNF805 -0.47 -6.35 -0.36 9.56e-10 Hyperactive-impulsive symptoms; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07159286 chr12:133779169 ZNF268 -0.56 -6.4 -0.37 6.84e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs45524643 chr16:89815824 G/A cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs7312933 1.000 rs3229 chr12:42475888 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.38 5.05 0.3 8.32e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg27165867 chr14:105738592 BRF1 -0.55 -5.92 -0.34 9.91e-9 Mean platelet volume;Platelet distribution width; CESC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg09359103 chr1:154839909 KCNN3 0.46 7.72 0.43 2.39e-13 Prostate cancer; CESC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg02071572 chr4:1403502 NA 0.38 5.61 0.33 5.2e-8 Longevity; CESC cis rs7474896 0.537 rs1208683 chr10:38093723 A/G cg25427524 chr10:38739819 LOC399744 0.46 5.03 0.3 8.97e-7 Obesity (extreme); CESC cis rs4319547 0.876 rs10846978 chr12:122964708 T/C cg23029597 chr12:123009494 RSRC2 -0.5 -5.52 -0.32 7.88e-8 Body mass index; CESC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg21644426 chr2:191273491 MFSD6 -0.49 -6.68 -0.38 1.42e-10 Pulse pressure; CESC cis rs9583531 0.600 rs9555726 chr13:111368316 C/T cg24331049 chr13:111365604 ING1 0.67 9.59 0.51 7.01e-19 Coronary artery disease; CESC cis rs11718455 0.960 rs35277738 chr3:44006732 T/C cg08738300 chr3:44038990 NA 0.46 6.14 0.35 3.03e-9 Coronary artery disease; CESC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.55 6.63 0.38 1.86e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6964587 0.621 rs38798 chr7:92044539 C/A cg17063962 chr7:91808500 NA -0.52 -7.49 -0.42 1.05e-12 Breast cancer; CESC cis rs611744 0.523 rs13253581 chr8:109343105 A/G cg21045802 chr8:109455806 TTC35 0.58 7.04 0.4 1.69e-11 Dupuytren's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09068198 chr2:65357064 RAB1A -0.47 -6.89 -0.39 4.05e-11 Gambling; CESC cis rs7216064 1.000 rs62084246 chr17:65867911 G/C cg07042672 chr17:66097459 LOC651250 -0.54 -5.59 -0.32 5.61e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs7615952 0.599 rs16834938 chr3:125706046 C/T cg07211511 chr3:129823064 LOC729375 -0.54 -6.56 -0.37 2.75e-10 Blood pressure (smoking interaction); CESC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.69 -7.85 -0.43 1.04e-13 Gut microbiome composition (summer); CESC cis rs9837602 1.000 rs6806178 chr3:99780393 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 6.78 0.38 8e-11 Breast cancer; CESC cis rs4268898 0.896 rs2702042 chr2:24546542 C/T cg20701182 chr2:24300061 SF3B14 0.47 5.85 0.34 1.44e-8 Asthma; CESC cis rs4253772 0.515 rs7287164 chr22:46781008 T/C cg24881330 chr22:46731750 TRMU 0.8 5.49 0.32 9.33e-8 LDL cholesterol;Cholesterol, total; CESC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC cis rs3857067 1.000 rs3857068 chr4:95026494 C/G cg11021082 chr4:95130006 SMARCAD1 0.54 8.45 0.46 1.98e-15 QT interval; CESC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg18758796 chr5:131593413 PDLIM4 0.46 6.4 0.37 7.1e-10 Breast cancer; CESC cis rs7119038 0.731 rs28409215 chr11:118679304 G/A cg19308663 chr11:118741387 NA 0.4 5.03 0.3 9e-7 Sjögren's syndrome; CESC cis rs1371867 0.641 rs1788209 chr8:101337056 C/T cg11906718 chr8:101322791 RNF19A 0.48 6.22 0.36 1.97e-9 Atrioventricular conduction; CESC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg18252515 chr7:66147081 NA 0.48 6.47 0.37 4.62e-10 Aortic root size; CESC cis rs2180341 1.000 rs9375499 chr6:127618072 T/C cg27446573 chr6:127587934 RNF146 1.08 16.13 0.7 3.14e-41 Breast cancer; CESC cis rs10465746 0.967 rs12118434 chr1:84328629 C/T cg10977910 chr1:84465055 TTLL7 0.47 6.49 0.37 4.22e-10 Obesity-related traits; CESC cis rs9308433 0.553 rs1048791 chr1:214511519 T/C cg06198575 chr1:214491504 SMYD2 0.44 5.05 0.3 8.27e-7 IgG glycosylation; CESC cis rs7666738 0.830 rs7659420 chr4:98878714 G/C cg05340658 chr4:99064831 C4orf37 0.78 11.69 0.58 9.42e-26 Colonoscopy-negative controls vs population controls; CESC cis rs9308731 1.000 rs13396983 chr2:111900598 A/G cg04202892 chr2:111875749 ACOXL 0.37 5.37 0.31 1.71e-7 Chronic lymphocytic leukemia; CESC cis rs13095912 1.000 rs6784842 chr3:185342723 C/T cg11274856 chr3:185301563 NA 0.34 5.43 0.32 1.31e-7 Systolic blood pressure; CESC cis rs4727027 0.769 rs10952797 chr7:148816722 A/T cg23583168 chr7:148888333 NA -0.78 -12.25 -0.6 1.2100000000000001e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6448317 0.863 rs2695228 chr4:24901985 C/T cg21108841 chr4:24914750 CCDC149 0.49 6.14 0.35 3.07e-9 Heschl's gyrus morphology; CESC trans rs921968 0.541 rs593888 chr2:219427597 A/G cg15547669 chr20:2781122 CPXM1 0.36 6.04 0.35 5.31e-9 Mean corpuscular hemoglobin concentration; CESC cis rs1448094 0.717 rs60713909 chr12:86294469 C/G cg02569458 chr12:86230093 RASSF9 0.36 5.14 0.3 5.46e-7 Major depressive disorder; CESC cis rs6732160 0.838 rs13411380 chr2:73382846 G/C cg01422370 chr2:73384389 NA 0.44 7.58 0.42 5.89e-13 Intelligence (multi-trait analysis); CESC cis rs4835473 0.897 rs4835095 chr4:144881584 A/T cg25736465 chr4:144833511 NA 0.41 6.05 0.35 4.79e-9 Immature fraction of reticulocytes; CESC trans rs3942852 0.726 rs1503171 chr11:48175152 T/C cg15704280 chr7:45808275 SEPT13 -0.75 -8.6 -0.47 7.22e-16 Acute lymphoblastic leukemia (childhood); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15831200 chr1:110765724 KCNC4 0.35 6.0 0.35 6.29e-9 Gambling; CESC cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg13877915 chr19:58951672 ZNF132 0.39 5.81 0.34 1.83e-8 Uric acid clearance; CESC cis rs9303401 0.703 rs8072182 chr17:57211213 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.57 7.56 0.42 6.48e-13 Cognitive test performance; CESC cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg06713675 chr4:122721982 EXOSC9 -0.44 -6.13 -0.35 3.23e-9 Type 2 diabetes; CESC cis rs12079745 0.590 rs35144581 chr1:169183588 C/T cg09363564 chr1:169337483 NME7;BLZF1 -0.99 -6.11 -0.35 3.47e-9 QT interval; CESC cis rs78456975 0.943 rs10470006 chr2:1580971 A/C cg26248373 chr2:1572462 NA -0.51 -5.19 -0.3 4.24e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg23131131 chr22:24373011 LOC391322 -0.69 -9.45 -0.5 1.87e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs11792861 0.888 rs11794648 chr9:111829792 C/T cg13535736 chr9:111863775 C9orf5 -0.49 -6.64 -0.38 1.75e-10 Menarche (age at onset); CESC trans rs7618501 0.699 rs6446187 chr3:49907111 C/A cg21659725 chr3:3221576 CRBN 0.58 8.2 0.45 1.04e-14 Intelligence (multi-trait analysis); CESC cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg09658497 chr7:2847517 GNA12 -0.35 -5.25 -0.31 3.07e-7 Height; CESC trans rs561341 0.882 rs2428337 chr17:30299467 C/T cg20587970 chr11:113659929 NA -1.43 -18.65 -0.75 3.85e-50 Hip circumference adjusted for BMI; CESC cis rs1062177 0.756 rs2964587 chr5:151119972 C/T cg12924095 chr5:151150029 G3BP1 -0.43 -5.34 -0.31 2e-7 Preschool internalizing problems; CESC cis rs55728055 0.661 rs16989278 chr22:31957167 A/G cg01338084 chr22:32026380 PISD 1.26 8.23 0.45 8.62e-15 Age-related hearing impairment; CESC cis rs4523957 0.928 rs452363 chr17:2194028 T/C cg16513277 chr17:2031491 SMG6 0.59 8.08 0.44 2.29e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.52 7.06 0.4 1.46e-11 Lymphocyte counts; CESC cis rs2439831 0.850 rs3816792 chr15:44116986 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.66 -6.06 -0.35 4.62e-9 Lung cancer in ever smokers; CESC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg18876405 chr7:65276391 NA -0.53 -7.22 -0.41 5.6e-12 Aortic root size; CESC cis rs4132509 0.566 rs1578275 chr1:243680442 C/G cg21452805 chr1:244014465 NA -0.55 -6.19 -0.36 2.33e-9 RR interval (heart rate); CESC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg03538708 chr1:25844672 NA 0.37 5.43 0.32 1.3e-7 Erythrocyte sedimentation rate; CESC cis rs2688608 0.560 rs10128354 chr10:75470045 T/C cg23231163 chr10:75533350 FUT11 -0.36 -5.53 -0.32 7.78e-8 Inflammatory bowel disease; CESC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg00290607 chr11:67383545 NA 0.5 7.39 0.41 1.91e-12 Mean corpuscular volume; CESC trans rs7819412 0.505 rs67849263 chr8:11007544 G/T cg15556689 chr8:8085844 FLJ10661 -0.54 -6.27 -0.36 1.46e-9 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17004975 chr10:81743287 NA -0.58 -7.21 -0.4 5.71e-12 Gut microbiome composition (summer); CESC cis rs3768617 0.510 rs10797844 chr1:183082067 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 14.13 0.66 3.47e-34 Fuchs's corneal dystrophy; CESC cis rs2573652 1.000 rs2727196 chr15:100513529 C/T cg09918751 chr15:100517450 ADAMTS17 -0.39 -7.61 -0.42 4.79e-13 Height; CESC cis rs8070128 0.534 rs2955350 chr17:17953548 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.81 -0.48 1.7e-16 Total body bone mineral density; CESC cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg06212747 chr3:49208901 KLHDC8B 0.68 9.34 0.5 3.96e-18 Parkinson's disease; CESC cis rs7523050 0.643 rs12741194 chr1:109400390 T/C cg08274380 chr1:109419600 GPSM2 0.83 5.58 0.32 5.89e-8 Fat distribution (HIV); CESC trans rs208520 0.837 rs208498 chr6:66931560 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.81 -9.62 -0.51 5.57e-19 Exhaled nitric oxide output; CESC cis rs763121 0.853 rs35565791 chr22:39063011 C/A cg06022373 chr22:39101656 GTPBP1 0.88 13.95 0.65 1.51e-33 Menopause (age at onset); CESC cis rs561341 1.000 rs501312 chr17:30329066 A/G cg00745463 chr17:30367425 LRRC37B -0.83 -7.54 -0.42 7.69e-13 Hip circumference adjusted for BMI; CESC cis rs6121246 0.954 rs6060992 chr20:30431255 G/T cg13852791 chr20:30311386 BCL2L1 0.75 7.38 0.41 2.1e-12 Mean corpuscular hemoglobin; CESC cis rs72945132 0.882 rs67529561 chr11:70162055 G/T cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs2243480 1.000 rs6460274 chr7:65628484 T/A cg12463550 chr7:65579703 CRCP -0.73 -5.71 -0.33 3.1e-8 Diabetic kidney disease; CESC cis rs473651 0.967 rs483042 chr2:239335320 A/G cg21699342 chr2:239360505 ASB1 0.54 9.13 0.49 1.82e-17 Multiple system atrophy; CESC cis rs11608355 0.545 rs11609019 chr12:109895958 G/A cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs258892 0.793 rs34657 chr5:72148196 G/A cg21869765 chr5:72125136 TNPO1 0.44 5.55 0.32 6.92e-8 Small cell lung carcinoma; CESC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg17971929 chr21:40555470 PSMG1 -0.6 -8.02 -0.44 3.31e-14 Menarche (age at onset); CESC cis rs9908102 0.740 rs11545302 chr17:12899963 T/C cg26162695 chr17:12921313 ELAC2 0.52 5.75 0.33 2.5e-8 Schizophrenia; CESC cis rs67460515 0.527 rs34221255 chr3:160854123 T/C cg03342759 chr3:160939853 NMD3 -0.41 -5.38 -0.31 1.66e-7 Parkinson's disease; CESC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs11792861 0.926 rs72607163 chr9:111803128 G/T cg05043794 chr9:111880884 C9orf5 -0.4 -6.63 -0.38 1.86e-10 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05205601 chr15:64885318 ZNF609 -0.53 -6.13 -0.35 3.17e-9 Gut microbiome composition (summer); CESC cis rs9308433 0.553 rs11120299 chr1:214509407 C/A cg06198575 chr1:214491504 SMYD2 0.48 5.79 0.34 2.01e-8 IgG glycosylation; CESC cis rs17641971 0.599 rs2385230 chr8:50015755 A/G cg00325661 chr8:49890786 NA 0.38 5.33 0.31 2.15e-7 Blood metabolite levels; CESC cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.65 0.33 4.1e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs9951602 0.573 rs8098953 chr18:76648734 A/G cg02800362 chr5:177631904 HNRNPAB 0.65 8.65 0.47 5.07e-16 Obesity-related traits; CESC cis rs4595586 0.545 rs12812262 chr12:39392567 T/A cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs7100689 0.577 rs9285726 chr10:82035150 A/T cg09936400 chr10:82049201 MAT1A 0.4 5.85 0.34 1.43e-8 Post bronchodilator FEV1; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20340149 chr2:122407145 CLASP1 -0.46 -6.66 -0.38 1.55e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13191362 0.507 rs13212746 chr6:163203092 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.47 5.53 0.32 7.67e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs6931865 0.508 rs55767626 chr6:144065552 A/G cg02864954 chr6:154535553 IPCEF1;OPRM1 0.39 6.36 0.36 8.74e-10 Erectile dysfunction in type 1 diabetes; CESC cis rs9911578 0.935 rs302873 chr17:56769481 C/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.11 -0.4 1.07e-11 Intelligence (multi-trait analysis); CESC cis rs2901656 0.502 rs9425601 chr1:172377262 G/A cg03748243 chr1:172413542 C1orf105;PIGC -0.4 -5.49 -0.32 9.18e-8 Red cell distribution width;Platelet distribution width; CESC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg06420487 chr17:61919686 SMARCD2 0.44 5.29 0.31 2.53e-7 Height; CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg26335602 chr6:28129616 ZNF389 0.53 6.95 0.39 2.83e-11 Depression; CESC cis rs2228479 0.850 rs62054640 chr16:89823157 C/T cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs4953076 0.613 rs11124981 chr2:44462133 A/T cg04920474 chr2:44395004 PPM1B 0.6 7.75 0.43 1.92e-13 Height; CESC cis rs10129255 0.957 rs8005468 chr14:107142448 C/T cg07958169 chr14:107095056 NA -0.38 -5.21 -0.3 3.79e-7 Kawasaki disease; CESC cis rs9549260 0.564 rs4941989 chr13:41299687 T/C cg21288729 chr13:41239152 FOXO1 0.59 7.63 0.42 4.25e-13 Red blood cell count; CESC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.28 -0.31 2.7e-7 Total body bone mineral density; CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg07092213 chr7:1199455 ZFAND2A -0.44 -5.81 -0.34 1.83e-8 Longevity;Endometriosis; CESC cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg22875332 chr1:76189707 ACADM -0.58 -6.06 -0.35 4.53e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7208859 0.524 rs77498725 chr17:29063986 C/T cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs801193 0.935 rs2659899 chr7:66186721 A/G cg26939375 chr7:64535504 NA 0.64 8.67 0.47 4.39e-16 Aortic root size; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg04203298 chr11:59521722 STX3 0.44 6.22 0.36 1.91e-9 Bronchopulmonary dysplasia; CESC cis rs7089973 0.872 rs7918388 chr10:116614563 T/C cg23260525 chr10:116636907 FAM160B1 0.38 6.37 0.36 8.29e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2549003 1.000 rs7735073 chr5:131815357 G/A cg02551604 chr5:131831745 NA -0.36 -5.08 -0.3 7.22e-7 Asthma (sex interaction); CESC cis rs2637266 0.783 rs7900420 chr10:78476543 T/C cg18941641 chr10:78392320 NA 0.4 7.59 0.42 5.51e-13 Pulmonary function; CESC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -7.13 -0.4 9.34e-12 Extrinsic epigenetic age acceleration; CESC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.0 0.35 6.55e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg11301795 chr4:187892539 NA -0.74 -11.64 -0.58 1.46e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg23711669 chr6:146136114 FBXO30 -0.98 -15.11 -0.68 1.2e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs7903847 0.692 rs7900255 chr10:99157575 G/A cg20016023 chr10:99160130 RRP12 -0.3 -5.19 -0.3 4.18e-7 Granulocyte percentage of myeloid white cells; CESC cis rs258892 0.895 rs34782328 chr5:72060974 T/C cg21869765 chr5:72125136 TNPO1 -0.43 -5.35 -0.31 1.93e-7 Small cell lung carcinoma; CESC cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg05535760 chr7:792225 HEATR2 0.88 11.01 0.56 1.78e-23 Cerebrospinal P-tau181p levels; CESC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg27266027 chr21:40555129 PSMG1 0.43 5.17 0.3 4.72e-7 Cognitive function; CESC trans rs1814175 0.791 rs7395713 chr11:49877887 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -20.77 -0.79 1.6e-57 Height; CESC cis rs6912958 0.559 rs242281 chr6:88048916 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.99 0.56 2.06e-23 Monocyte percentage of white cells; CESC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg19717773 chr7:2847554 GNA12 -0.44 -6.46 -0.37 4.99e-10 Height; CESC cis rs7666738 0.830 rs1120708 chr4:98931260 G/C cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC cis rs17253792 0.822 rs28831725 chr14:56087569 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs7267979 0.903 rs6132819 chr20:25218618 C/G cg08601574 chr20:25228251 PYGB 0.42 5.88 0.34 1.23e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7580658 0.676 rs58475809 chr2:128002650 A/G cg10021288 chr2:128175891 PROC -0.37 -6.03 -0.35 5.53e-9 Protein C levels; CESC cis rs977987 0.815 rs11149818 chr16:75419373 G/A cg03315344 chr16:75512273 CHST6 0.4 5.77 0.33 2.22e-8 Dupuytren's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08718230 chr6:21596358 SOX4 -0.49 -6.47 -0.37 4.62e-10 Ulcerative colitis; CESC cis rs7927592 0.830 rs10896339 chr11:68302846 G/C cg16797656 chr11:68205561 LRP5 0.41 6.15 0.35 2.76e-9 Total body bone mineral density; CESC cis rs6460942 1.000 rs77494477 chr7:12315302 A/T cg20607287 chr7:12443886 VWDE -0.79 -8.51 -0.46 1.32e-15 Coronary artery disease; CESC cis rs7914558 0.966 rs4917997 chr10:104945213 A/G cg04362960 chr10:104952993 NT5C2 0.46 6.16 0.35 2.74e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1707322 0.717 rs1547925 chr1:46085356 C/T cg03146154 chr1:46216737 IPP -0.78 -10.93 -0.56 3.39e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16087482 chr17:79683232 SLC25A10 0.41 6.38 0.36 7.85e-10 Fibrinogen levels; CESC trans rs6479874 0.920 rs7893612 chr10:52761458 G/A cg14115756 chr9:125795935 GPR21;RABGAP1 0.68 6.0 0.35 6.41e-9 Migraine; CESC cis rs2243480 1.000 rs56291018 chr7:65390339 G/A cg13147721 chr7:65941812 NA -0.88 -8.15 -0.45 1.47e-14 Diabetic kidney disease; CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg01420088 chr10:101491661 CUTC;COX15 0.54 6.04 0.35 5.18e-9 Endometrial cancer; CESC cis rs4563143 0.514 rs73029079 chr19:29294903 A/G cg12756686 chr19:29218302 NA 0.54 6.27 0.36 1.46e-9 Methadone dose in opioid dependence; CESC cis rs7267979 0.706 rs6037069 chr20:25234166 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.79 15.3 0.68 2.73e-38 Liver enzyme levels (alkaline phosphatase); CESC cis rs7678296 0.649 rs60691639 chr4:37239925 T/C cg06805348 chr4:37245195 KIAA1239 0.53 5.79 0.33 2.04e-8 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs2011503 0.941 rs11555053 chr19:19390185 G/A cg11584989 chr19:19387371 SF4 0.61 7.3 0.41 3.41e-12 Bipolar disorder; CESC cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00688900 chr17:34901364 GGNBP2 0.42 6.03 0.35 5.56e-9 Fibrinogen levels; CESC cis rs870825 0.616 rs2141257 chr4:185609463 C/T cg04058563 chr4:185651563 MLF1IP -0.63 -6.14 -0.35 3.01e-9 Blood protein levels; CESC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.61 0.47 6.49e-16 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15092787 chr17:74581715 ST6GALNAC2 -0.48 -6.49 -0.37 4.08e-10 Fibrinogen levels; CESC cis rs9309473 1.000 rs10187192 chr2:73713500 T/C cg20560298 chr2:73613845 ALMS1 -0.55 -6.86 -0.39 4.78e-11 Metabolite levels; CESC cis rs11122272 0.675 rs1416913 chr1:231533206 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs6062302 0.522 rs13043255 chr20:62218916 C/G cg06363034 chr20:62225388 GMEB2 -0.51 -6.57 -0.37 2.68e-10 Glioblastoma; CESC cis rs3008870 0.920 rs2755253 chr1:67470843 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.77 10.52 0.54 7.66e-22 Lymphocyte percentage of white cells; CESC cis rs6963495 0.818 rs73192115 chr7:105169605 T/A cg02135003 chr7:105160482 PUS7 -0.46 -5.5 -0.32 9.1e-8 Bipolar disorder (body mass index interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10217975 chr3:52091484 DUSP7 -0.47 -6.3 -0.36 1.21e-9 Fibrinogen levels; CESC cis rs71403859 0.502 rs12708914 chr16:71470636 G/A cg08717414 chr16:71523259 ZNF19 -0.7 -7.23 -0.41 5.03e-12 Post bronchodilator FEV1; CESC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.62 6.4 0.37 7.19e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs870825 0.698 rs7673203 chr4:185625397 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs6088590 1.000 rs6120750 chr20:33465289 A/C cg06115741 chr20:33292138 TP53INP2 0.63 7.65 0.43 3.83e-13 Coronary artery disease; CESC cis rs1044826 0.642 rs295473 chr3:139215585 T/C cg00490450 chr3:139108681 COPB2 0.45 5.53 0.32 7.8e-8 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01708236 chr6:44233446 NFKBIE 0.64 7.02 0.4 1.9e-11 Gut microbiome composition (summer); CESC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg02569458 chr12:86230093 RASSF9 0.49 7.22 0.41 5.67e-12 Major depressive disorder; CESC cis rs7246657 0.943 rs2112923 chr19:37940327 C/T cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.69e-9 Coronary artery calcification; CESC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.29 0.31 2.61e-7 Menopause (age at onset); CESC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg16049864 chr8:95962084 TP53INP1 -0.64 -11.35 -0.57 1.34e-24 Type 2 diabetes; CESC trans rs6445797 0.632 rs2291499 chr3:56658481 G/C cg15444621 chr13:113611794 NA 0.34 6.1 0.35 3.64e-9 Gastritis; CESC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg03395511 chr6:291903 DUSP22 -0.73 -9.54 -0.51 1.01e-18 Menopause (age at onset); CESC cis rs17376456 0.825 rs10038828 chr5:93124056 C/T cg25358565 chr5:93447407 FAM172A 1.11 10.66 0.55 2.6e-22 Diabetic retinopathy; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12444081 chr17:16521159 NA -0.46 -6.37 -0.36 8.21e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs861020 0.959 rs658860 chr1:209990549 C/T cg05527609 chr1:210001259 C1orf107 1.08 13.26 0.63 4.16e-31 Orofacial clefts; CESC cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg05340658 chr4:99064831 C4orf37 0.81 12.4 0.61 3.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs10979 0.571 rs7764231 chr6:143919151 C/G cg25407410 chr6:143891975 LOC285740 -0.47 -5.85 -0.34 1.42e-8 Hypospadias; CESC cis rs2439831 0.850 rs694985 chr15:43813387 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.78 8.47 0.46 1.69e-15 Lung cancer in ever smokers; CESC cis rs9487051 0.621 rs351750 chr6:109533385 T/C cg01475377 chr6:109611718 NA -0.39 -5.16 -0.3 4.76e-7 Reticulocyte fraction of red cells; CESC cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.51 -6.17 -0.35 2.48e-9 Breast cancer; CESC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg11764359 chr7:65958608 NA -0.64 -8.11 -0.45 1.9e-14 Aortic root size; CESC cis rs2797685 0.853 rs707462 chr1:7849880 A/G cg04725166 chr1:7887271 PER3 -0.44 -6.24 -0.36 1.7e-9 Crohn's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.1.2648414R chr1:113158148 ST7L -0.47 -6.0 -0.35 6.37e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC trans rs208520 1.000 rs208527 chr6:66957209 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -9.42 -0.5 2.36e-18 Exhaled nitric oxide output; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06397510 chr1:32403634 PTP4A2 -0.48 -6.42 -0.37 6.27e-10 Ulcerative colitis; CESC cis rs6499255 1.000 rs12925371 chr16:69773885 G/A cg15192750 chr16:69999425 NA 0.54 6.48 0.37 4.42e-10 IgE levels; CESC cis rs7903847 0.642 rs11189200 chr10:99156273 C/G cg20016023 chr10:99160130 RRP12 -0.3 -5.19 -0.3 4.18e-7 Granulocyte percentage of myeloid white cells; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01604348 chr19:54663591 LENG1 0.46 6.41 0.37 6.58e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11645898 0.688 rs437638 chr16:72095452 C/T cg14768367 chr16:72042858 DHODH -0.79 -6.25 -0.36 1.65e-9 Blood protein levels; CESC trans rs61931739 0.517 rs10844830 chr12:34308133 C/T cg26384229 chr12:38710491 ALG10B 0.44 6.01 0.35 6.07e-9 Morning vs. evening chronotype; CESC cis rs9811920 0.609 rs793466 chr3:99609837 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs8077889 0.672 rs4793028 chr17:41857212 T/C cg26893861 chr17:41843967 DUSP3 1.01 18.86 0.76 6.61e-51 Triglycerides; CESC cis rs1051424 0.651 rs1292063 chr17:57907768 T/A cg13753209 chr17:57696993 CLTC -0.67 -8.48 -0.46 1.6e-15 Obesity-related traits; CESC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg07395648 chr5:131743802 NA -0.43 -5.64 -0.33 4.43e-8 Breast cancer; CESC cis rs6088580 0.561 rs3761147 chr20:32996689 G/T cg08999081 chr20:33150536 PIGU -0.63 -10.83 -0.55 7.31e-23 Glomerular filtration rate (creatinine); CESC cis rs4803468 1.000 rs11883104 chr19:41923799 T/C cg14132834 chr19:41945861 ATP5SL -0.68 -8.39 -0.46 2.9e-15 Height; CESC cis rs854765 0.547 rs2955370 chr17:17966945 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.48 -6.15 -0.35 2.87e-9 Total body bone mineral density; CESC cis rs4594175 0.926 rs9323206 chr14:51621800 C/T cg23942311 chr14:51606299 NA 0.41 6.23 0.36 1.78e-9 Cancer; CESC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg04267008 chr7:1944627 MAD1L1 -0.54 -6.51 -0.37 3.78e-10 Bipolar disorder and schizophrenia; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23939166 chr14:55032812 NA -0.45 -6.13 -0.35 3.17e-9 Asthma; CESC cis rs3785574 0.962 rs2727280 chr17:61918082 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.06 16.57 0.71 8.06e-43 Height; CESC cis rs921968 0.541 rs488767 chr2:219466860 G/T cg02176678 chr2:219576539 TTLL4 0.44 7.6 0.42 5.18e-13 Mean corpuscular hemoglobin concentration; CESC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.15 0.4 8.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs73206853 0.764 rs73206857 chr12:110767721 T/A cg04375036 chr12:111181819 PPP1CC -0.55 -5.04 -0.3 8.52e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs5753618 0.561 rs2283879 chr22:31638448 G/A cg13145458 chr22:31556086 RNF185 0.46 5.21 0.3 3.86e-7 Colorectal cancer; CESC trans rs62103177 0.759 rs9956512 chr18:77607517 G/A cg05926928 chr17:57297772 GDPD1 1.14 11.63 0.58 1.58e-25 Opioid sensitivity; CESC cis rs4332037 0.754 rs62436669 chr7:1926636 G/A cg23422044 chr7:1970798 MAD1L1 -0.58 -6.06 -0.35 4.66e-9 Bipolar disorder; CESC cis rs447 1.000 rs6978184 chr7:83778360 C/T cg22846510 chr7:83753280 SEMA3A -0.42 -5.08 -0.3 7e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6121246 0.609 rs6089054 chr20:30323141 A/G cg13852791 chr20:30311386 BCL2L1 0.81 10.36 0.54 2.4e-21 Mean corpuscular hemoglobin; CESC cis rs7103648 0.669 rs7131262 chr11:47836302 T/A cg10504702 chr11:47789108 FNBP4 0.43 5.34 0.31 2.03e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs2733201 1.000 rs4419034 chr15:44348400 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.66 -6.28 -0.36 1.39e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs7202877 0.706 rs247443 chr16:75465073 G/C cg04384234 chr16:75411784 CFDP1 0.49 5.77 0.33 2.24e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 5.35 0.31 1.87e-7 Menopause (age at onset); CESC cis rs1448094 0.511 rs10863071 chr12:86145813 A/G cg02569458 chr12:86230093 RASSF9 -0.43 -6.65 -0.38 1.65e-10 Major depressive disorder; CESC cis rs4481887 0.741 rs7540715 chr1:248544206 C/T cg26353448 chr1:248524236 OR2T4 -0.37 -5.12 -0.3 5.85e-7 Common traits (Other); CESC cis rs2735413 0.709 rs1319049 chr16:78084610 T/G cg04733911 chr16:78082701 NA 0.52 8.4 0.46 2.69e-15 Systolic blood pressure (alcohol consumption interaction); CESC cis rs4906332 0.933 rs35999760 chr14:103924481 A/C cg09975044 chr14:104007538 NA 0.47 6.45 0.37 5.25e-10 Coronary artery disease; CESC cis rs11764590 0.666 rs3996325 chr7:2053747 T/C cg21782813 chr7:2030301 MAD1L1 -0.42 -5.27 -0.31 2.84e-7 Neuroticism; CESC cis rs6537837 0.838 rs6663547 chr1:110114229 A/C cg05049280 chr1:110155535 GNAT2 0.4 5.69 0.33 3.32e-8 Major depressive disorder; CESC cis rs9612 1.000 rs58896392 chr19:44269142 G/A cg08581076 chr19:44259116 C19orf61 0.53 6.05 0.35 4.88e-9 Exhaled nitric oxide output; CESC trans rs11098499 0.754 rs12506487 chr4:120271361 T/G cg25214090 chr10:38739885 LOC399744 0.6 8.3 0.45 5.33e-15 Corneal astigmatism; CESC cis rs10754283 0.967 rs10922680 chr1:90101326 C/T cg21401794 chr1:90099060 LRRC8C -0.67 -9.02 -0.48 3.79e-17 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg22823121 chr1:150693482 HORMAD1 0.36 5.05 0.3 8.1e-7 Melanoma; CESC cis rs920590 0.758 rs7011322 chr8:19661937 C/T cg01411142 chr8:19674711 INTS10 0.52 5.86 0.34 1.39e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg03060546 chr3:49711283 APEH 0.64 7.34 0.41 2.55e-12 Menarche (age at onset); CESC cis rs16854884 0.632 rs35716467 chr3:143684993 C/A cg01302019 chr3:143689584 C3orf58 -0.34 -5.17 -0.3 4.54e-7 Economic and political preferences (feminism/equality); CESC cis rs7561273 0.609 rs2160943 chr2:24288775 G/A cg20701182 chr2:24300061 SF3B14 0.45 6.03 0.35 5.41e-9 Quantitative traits; CESC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg12463550 chr7:65579703 CRCP 0.57 7.21 0.4 5.88e-12 Aortic root size; CESC cis rs7202877 0.706 rs4888375 chr16:75322356 T/C cg04384234 chr16:75411784 CFDP1 -0.46 -5.29 -0.31 2.55e-7 Type 2 diabetes;Type 1 diabetes; CESC cis rs11958404 0.932 rs56065211 chr5:157439386 C/T cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs1949733 0.523 rs56053534 chr4:8542876 G/A cg11789530 chr4:8429930 ACOX3 -0.58 -7.21 -0.41 5.71e-12 Response to antineoplastic agents; CESC trans rs116095464 0.558 rs56043030 chr5:220917 A/G cg00938859 chr5:1591904 SDHAP3 0.6 6.66 0.38 1.55e-10 Breast cancer; CESC cis rs12545109 0.732 rs1973629 chr8:57429583 A/G cg09654669 chr8:57350985 NA -0.62 -7.17 -0.4 7.37e-12 Obesity-related traits; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13789711 chr9:139743225 PHPT1 0.51 7.06 0.4 1.42e-11 Systemic lupus erythematosus; CESC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg19077165 chr18:44547161 KATNAL2 -0.52 -7.67 -0.43 3.34e-13 Personality dimensions; CESC cis rs763121 0.889 rs2267390 chr22:38889657 C/T cg14440974 chr22:39074834 NA -0.38 -5.16 -0.3 4.84e-7 Menopause (age at onset); CESC cis rs2404602 0.692 rs67570291 chr15:77020502 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs79149102 0.649 rs1531162 chr15:75111984 C/T cg09165964 chr15:75287851 SCAMP5 -0.69 -5.44 -0.32 1.21e-7 Lung cancer; CESC cis rs7927771 0.524 rs61895760 chr11:47794538 G/C cg20307385 chr11:47447363 PSMC3 0.61 8.64 0.47 5.45e-16 Subjective well-being; CESC cis rs12347191 0.500 rs1912998 chr9:100621386 T/C cg13688889 chr9:100608707 NA -0.91 -13.42 -0.64 1.07e-31 Orofacial clefts; CESC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg18446336 chr7:2847575 GNA12 -0.39 -5.63 -0.33 4.55e-8 Height; CESC cis rs4889855 0.530 rs8080678 chr17:78544003 G/T cg16591659 chr17:78472290 NA 0.37 6.18 0.35 2.45e-9 Fractional excretion of uric acid; CESC cis rs2073300 0.609 rs3746733 chr20:23349749 C/T cg12062639 chr20:23401060 NAPB 0.98 7.92 0.44 6.56e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs643506 0.817 rs658373 chr11:111682991 T/C cg09085632 chr11:111637200 PPP2R1B 0.41 5.45 0.32 1.13e-7 Breast cancer; CESC cis rs7818688 1.000 rs28440026 chr8:96026744 C/G cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg24308560 chr3:49941425 MST1R 0.62 9.1 0.49 2.24e-17 Intelligence (multi-trait analysis); CESC cis rs6429082 0.597 rs6683978 chr1:235541425 A/G cg26050004 chr1:235667680 B3GALNT2 -0.54 -6.73 -0.38 1.02e-10 Adiposity; CESC cis rs11658309 1 rs11658309 chr17:17762247 T/G cg09796270 chr17:17721594 SREBF1 -0.43 -6.15 -0.35 2.77e-9 Strep throat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25910647 chr15:62539093 NA -0.64 -7.57 -0.42 6.19e-13 Gut microbiome composition (summer); CESC cis rs938554 0.571 rs4144 chr4:10016322 T/C cg11266682 chr4:10021025 SLC2A9 0.56 7.75 0.43 2.03e-13 Blood metabolite levels; CESC cis rs12477438 0.765 rs28648058 chr2:99696417 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.62 -0.47 6.05e-16 Chronic sinus infection; CESC cis rs2439831 1.000 rs2467739 chr15:43740196 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.56 0.54 5.55e-22 Lung cancer in ever smokers; CESC cis rs10203711 0.966 rs4998694 chr2:239564713 C/T cg14580085 chr2:239553406 NA 0.34 5.08 0.3 7.02e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg22823121 chr1:150693482 HORMAD1 0.47 6.66 0.38 1.6e-10 Melanoma; CESC cis rs4604732 0.631 rs74154676 chr1:247625894 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4727027 0.901 rs34201592 chr7:148842403 C/G cg23583168 chr7:148888333 NA -0.73 -10.81 -0.55 8.24e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1499972 0.938 rs843854 chr3:117757755 A/G cg07612923 chr3:117604196 NA 0.75 5.65 0.33 4.12e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26312950 chr7:5391498 TNRC18 -0.56 -6.13 -0.35 3.25e-9 Gut microbiome composition (summer); CESC cis rs1372520 0.684 rs1442144 chr4:90736113 T/C cg15133208 chr4:90757351 SNCA -0.42 -5.74 -0.33 2.57e-8 Neuroticism; CESC cis rs10832963 0.924 rs10500834 chr11:18638712 A/T cg20219074 chr11:18656078 SPTY2D1 0.8 11.77 0.59 5.17e-26 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00563768 chr17:34174170 TAF15 -0.56 -6.97 -0.39 2.53e-11 Gut microbiome composition (summer); CESC cis rs155076 1.000 rs195570 chr13:21867580 T/G cg11317459 chr13:21872234 NA -1.12 -12.77 -0.62 1.94e-29 White matter hyperintensity burden; CESC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.45 6.05 0.35 4.97e-9 Bipolar disorder; CESC cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg18357645 chr12:58087776 OS9 -0.43 -6.13 -0.35 3.17e-9 Multiple sclerosis; CESC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg22920501 chr2:26401640 FAM59B -0.69 -8.22 -0.45 9.07e-15 Gut microbiome composition (summer); CESC cis rs76878669 0.561 rs4244813 chr11:66129488 G/C cg18002602 chr11:66138449 SLC29A2 0.4 6.65 0.38 1.71e-10 Educational attainment (years of education); CESC cis rs7071206 0.704 rs11002234 chr10:79434458 A/G cg07817648 chr10:79422355 NA -0.69 -8.68 -0.47 4.16e-16 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05087722 chr2:241404981 GPC1 -0.57 -6.6 -0.38 2.17e-10 Gut microbiome composition (summer); CESC cis rs4253772 0.530 rs79354880 chr22:46746419 C/A cg00784671 chr22:46762841 CELSR1 -0.65 -6.26 -0.36 1.51e-9 LDL cholesterol;Cholesterol, total; CESC trans rs208520 0.507 rs9453585 chr6:66796668 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -23.22 -0.82 7.87e-66 Exhaled nitric oxide output; CESC cis rs67311347 1.000 rs73078163 chr3:40479958 C/T cg24209194 chr3:40518798 ZNF619 0.51 6.2 0.36 2.18e-9 Renal cell carcinoma; CESC cis rs9457247 1.000 rs402749 chr6:167386104 C/T cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC cis rs2952156 0.959 rs1495102 chr17:37832093 T/C cg00129232 chr17:37814104 STARD3 -0.71 -9.32 -0.5 4.68e-18 Asthma; CESC cis rs8114671 0.562 rs6087653 chr20:33522054 T/C cg24642439 chr20:33292090 TP53INP2 0.43 5.19 0.3 4.19e-7 Height; CESC cis rs3845702 0.736 rs6727890 chr2:180832675 T/C cg01881094 chr2:180872142 CWC22 -1.02 -9.36 -0.5 3.69e-18 Schizophrenia; CESC cis rs754466 0.580 rs10824575 chr10:79549047 A/G cg17075019 chr10:79541650 NA -0.86 -13.56 -0.64 3.65e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs929354 0.742 rs62491945 chr7:156955580 G/A cg05182265 chr7:156933206 UBE3C -0.5 -7.29 -0.41 3.49e-12 Body mass index; CESC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg06582575 chr6:163149167 PACRG;PARK2 0.75 7.87 0.44 9.12e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6693567 0.565 rs2264417 chr1:150368501 C/T cg09579323 chr1:150459698 TARS2 0.48 6.03 0.35 5.58e-9 Migraine; CESC cis rs367615 0.918 rs10070104 chr5:108866438 C/T cg17395555 chr5:108820864 NA -0.55 -8.22 -0.45 9.28e-15 Colorectal cancer (SNP x SNP interaction); CESC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg04025307 chr7:1156635 C7orf50 0.6 10.36 0.54 2.53e-21 Longevity;Endometriosis; CESC cis rs2243480 1.000 rs316321 chr7:65611613 G/A cg12463550 chr7:65579703 CRCP 0.75 5.84 0.34 1.56e-8 Diabetic kidney disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10579840 chr8:99306110 NIPAL2 -0.44 -6.14 -0.35 3.05e-9 Gambling; CESC cis rs13191362 1.000 rs35754151 chr6:163074867 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 7.82 0.43 1.29e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2295499 0.816 rs9683572 chr4:2702698 C/T cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.21 -0.3 3.75e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11585767 chr3:112280782 ATG3;SLC35A5 0.5 6.21 0.36 2.08e-9 Gut microbiome composition (summer); CESC trans rs1728785 0.901 rs6499186 chr16:68660565 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.7 7.71 0.43 2.54e-13 Ulcerative colitis; CESC cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg02935154 chr7:12443704 VWDE -0.59 -6.39 -0.37 7.23e-10 Coronary artery disease; CESC cis rs7959452 0.640 rs4761233 chr12:69722880 T/C cg20891283 chr12:69753455 YEATS4 0.77 11.25 0.57 3.01e-24 Blood protein levels; CESC cis rs919433 0.963 rs2043016 chr2:198146381 C/T cg03934865 chr2:198174659 NA -0.49 -7.43 -0.42 1.47e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4704187 0.687 rs4340901 chr5:74404905 C/T cg03227963 chr5:74354835 NA 0.32 5.94 0.34 8.7e-9 Response to amphetamines; CESC cis rs13064411 0.696 rs869343 chr3:113226705 C/T cg18753928 chr3:113234510 CCDC52 -0.5 -6.13 -0.35 3.23e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs62229266 0.804 rs12483151 chr21:37419578 C/T cg12218747 chr21:37451666 NA -0.4 -5.72 -0.33 2.82e-8 Mitral valve prolapse; CESC cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg17366294 chr4:99064904 C4orf37 0.58 8.39 0.46 2.88e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 0.932 rs11941874 chr4:17666416 C/T cg16339924 chr4:17578868 LAP3 -0.64 -7.58 -0.42 5.95e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg18337363 chr3:52569053 NT5DC2 0.28 5.24 0.31 3.22e-7 Bipolar disorder; CESC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9399135 0.660 rs4267967 chr6:135272477 T/G cg22676075 chr6:135203613 NA 0.51 7.06 0.4 1.46e-11 Red blood cell count; CESC cis rs2985684 0.802 rs10150823 chr14:50051751 C/T cg04989706 chr14:50066350 PPIL5 -0.45 -5.05 -0.3 8.24e-7 Carotid intima media thickness; CESC cis rs412050 0.696 rs41283227 chr22:22275524 C/T cg17089214 chr22:22089827 YPEL1 0.69 5.88 0.34 1.24e-8 Attention deficit hyperactivity disorder; CESC cis rs17209837 0.831 rs56223611 chr7:87083157 C/A cg00919237 chr7:87102261 ABCB4 -0.53 -6.03 -0.35 5.36e-9 Gallbladder cancer; CESC cis rs6982240 0.514 rs72681579 chr8:142263074 G/A cg27411547 chr8:142287226 NA -0.53 -7.27 -0.41 4.07e-12 Tonsillectomy; CESC cis rs75064307 0.834 rs9288870 chr3:108113469 G/C cg03329597 chr3:108125523 MYH15 0.51 5.77 0.33 2.17e-8 Intelligence (multi-trait analysis); CESC cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg00745463 chr17:30367425 LRRC37B -0.78 -7.09 -0.4 1.2e-11 Hip circumference adjusted for BMI; CESC cis rs662064 1.000 rs662064 chr1:10557251 T/C cg20482658 chr1:10539492 PEX14 -0.36 -7.09 -0.4 1.24e-11 Asthma; CESC cis rs7918232 0.941 rs1085782 chr10:27440517 G/A cg14442939 chr10:27389572 ANKRD26 -0.67 -6.45 -0.37 5.34e-10 Breast cancer; CESC cis rs2637266 0.777 rs2637254 chr10:78312002 G/A cg18941641 chr10:78392320 NA 0.34 6.14 0.35 2.94e-9 Pulmonary function; CESC cis rs709400 0.598 rs11627529 chr14:104004557 C/T cg12935359 chr14:103987150 CKB -0.55 -7.91 -0.44 6.94e-14 Body mass index; CESC cis rs4332037 0.538 rs6951956 chr7:1934131 C/T cg23422044 chr7:1970798 MAD1L1 -0.43 -5.5 -0.32 9.08e-8 Bipolar disorder; CESC cis rs9905704 0.918 rs302857 chr17:56692387 C/G cg12560992 chr17:57184187 TRIM37 0.59 6.98 0.39 2.34e-11 Testicular germ cell tumor; CESC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg21724239 chr8:58056113 NA 0.6 5.54 0.32 7.11e-8 Developmental language disorder (linguistic errors); CESC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg13393036 chr8:95962371 TP53INP1 -0.49 -10.71 -0.55 1.73e-22 Type 2 diabetes; CESC cis rs1881797 1.000 rs12071797 chr1:247686871 A/G cg05639522 chr1:247681581 NA 0.46 6.02 0.35 5.84e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg11941060 chr3:133502564 NA -0.52 -7.18 -0.4 7.03e-12 Iron status biomarkers; CESC cis rs4253772 0.550 rs9615949 chr22:46722531 C/T cg18190219 chr22:46762943 CELSR1 -0.53 -5.5 -0.32 9.1e-8 LDL cholesterol;Cholesterol, total; CESC cis rs897984 0.762 rs11150601 chr16:30977799 G/A cg00531865 chr16:30841666 NA 0.51 7.02 0.4 1.83e-11 Dementia with Lewy bodies; CESC cis rs17433780 0.928 rs10922533 chr1:89456659 C/G cg09516651 chr1:89888402 LOC400759 0.66 8.99 0.48 4.92e-17 Carotid intima media thickness; CESC cis rs2012796 0.743 rs8020575 chr14:81859521 G/A cg02996355 chr14:81879375 NA 0.62 7.72 0.43 2.44e-13 Night sleep phenotypes; CESC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg18904891 chr8:8559673 CLDN23 0.66 7.24 0.41 4.75e-12 Obesity-related traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16242888 chr9:34179479 UBAP1 0.5 6.39 0.37 7.48e-10 Gut microbiota (bacterial taxa); CESC cis rs7267979 1.000 rs11087521 chr20:25440648 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.34 0.69 1.94e-38 Liver enzyme levels (alkaline phosphatase); CESC cis rs1348850 0.526 rs59972556 chr2:178399561 A/G cg22681709 chr2:178499509 PDE11A -0.49 -5.23 -0.31 3.39e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs148734725 1 rs148734725 chr3:49406708 G/A cg07274523 chr3:49395745 GPX1 0.68 8.49 0.46 1.55e-15 Educational attainment (college completion); CESC cis rs941408 0.515 rs1640265 chr19:2784405 C/T cg06609049 chr19:2785107 THOP1 0.85 12.84 0.62 1.16e-29 Total cholesterol levels; CESC cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg05347473 chr6:146136440 FBXO30 0.64 8.09 0.45 2.15e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs910316 1.000 rs4903275 chr14:75512509 C/T cg11812906 chr14:75593930 NEK9 0.89 14.59 0.67 8.27e-36 Height; CESC trans rs747782 0.646 rs61914719 chr11:48059091 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.07 0.35 4.48e-9 Intraocular pressure; CESC cis rs208520 1.000 rs12190773 chr6:66968194 T/C cg07460842 chr6:66804631 NA 0.9 10.34 0.54 2.79e-21 Exhaled nitric oxide output; CESC cis rs2279817 0.863 rs28481933 chr1:18026277 A/G cg21791023 chr1:18019539 ARHGEF10L 0.55 8.07 0.44 2.53e-14 Neuroticism; CESC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg00166722 chr3:10149974 C3orf24 0.53 6.37 0.36 8.45e-10 Alzheimer's disease; CESC cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 9.04 0.49 3.35e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9917256 0.831 rs908594 chr2:169133796 A/G cg07857142 chr2:169103971 STK39 0.54 5.03 0.3 9.04e-7 Parkinson's disease; CESC cis rs7827545 1.000 rs6992097 chr8:135565844 G/A cg17885191 chr8:135476712 NA 0.48 6.36 0.36 8.96e-10 Hypertension (SNP x SNP interaction); CESC cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg21918786 chr6:109611834 NA 0.38 5.79 0.33 2.02e-8 Reticulocyte fraction of red cells; CESC cis rs2977993 1 rs2977993 chr9:131608786 G/A cg00228799 chr9:131580591 ENDOG 0.45 5.56 0.32 6.55e-8 Schizophrenia; CESC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.58 0.42 5.75e-13 Tonsillectomy; CESC cis rs1801251 1.000 rs283479 chr2:233648754 A/G cg08000102 chr2:233561755 GIGYF2 0.67 9.28 0.5 6.17e-18 Coronary artery disease; CESC cis rs2273669 0.667 rs2356575 chr6:109367255 T/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.33 -0.36 1.02e-9 Prostate cancer; CESC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg13628971 chr7:2884303 GNA12 0.59 7.57 0.42 6.06e-13 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01833398 chr12:53894760 TARBP2;MAP3K12 0.65 7.29 0.41 3.54e-12 Gut microbiome composition (summer); CESC cis rs7089973 0.584 rs6585300 chr10:116639889 A/C cg23260525 chr10:116636907 FAM160B1 0.42 8.02 0.44 3.46e-14 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7940866 0.834 rs1594821 chr11:130835883 C/T cg12179176 chr11:130786555 SNX19 0.62 9.08 0.49 2.66e-17 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15844154 chr10:75173990 ANXA7 -0.62 -6.75 -0.38 9.46e-11 Gut microbiome composition (summer); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg24249734 chr3:127872125 EEFSEC -0.52 -6.88 -0.39 4.37e-11 Height; CESC cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg05283184 chr6:79620031 NA -0.43 -6.5 -0.37 3.91e-10 Intelligence (multi-trait analysis); CESC cis rs2439831 0.681 rs1549523 chr15:43624189 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.2 0.63 6.62e-31 Lung cancer in ever smokers; CESC cis rs1983170 1.000 rs597288 chr1:91999296 C/T cg21854759 chr1:92012499 NA 0.52 5.66 0.33 3.99e-8 Eosinophil percentage of white cells; CESC trans rs604222 0.508 rs9878726 chr3:193577995 C/T cg18397450 chr14:105830631 PACS2 -0.4 -6.02 -0.35 5.82e-9 Major depressive disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21654404 chr12:118814431 SUDS3 -0.5 -6.37 -0.36 8.3e-10 Ulcerative colitis; CESC cis rs4566357 0.595 rs6707159 chr2:227909339 T/A cg05526886 chr2:227700861 RHBDD1 -0.47 -6.13 -0.35 3.1e-9 Coronary artery disease; CESC cis rs17826219 0.706 rs55764512 chr17:29085758 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Body mass index; CESC cis rs637571 0.522 rs606978 chr11:65711517 A/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.47 6.19 0.36 2.3e-9 Eosinophil percentage of white cells; CESC cis rs1905108 0.510 rs12544004 chr8:49543160 T/C cg15397374 chr8:49647703 EFCAB1 0.31 5.27 0.31 2.85e-7 Colonoscopy-negative controls vs population controls; CESC cis rs748404 0.578 rs576557 chr15:43597737 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.56 8.89 0.48 9.41e-17 Lung cancer; CESC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg18479299 chr3:125709523 NA -0.48 -5.06 -0.3 7.98e-7 Blood pressure (smoking interaction); CESC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg03351412 chr1:154909251 PMVK 0.69 9.38 0.5 3.14e-18 Prostate cancer; CESC cis rs6500602 0.701 rs8129 chr16:4562351 A/G cg08645402 chr16:4508243 NA 0.42 6.41 0.37 6.74e-10 Schizophrenia; CESC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg12516959 chr21:47718080 NA -0.4 -5.8 -0.34 1.87e-8 Testicular germ cell tumor; CESC cis rs1055129 0.560 rs2305913 chr17:73922941 T/C cg10935138 chr17:73851978 WBP2 0.42 5.17 0.3 4.59e-7 White matter hyperintensity burden; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06623486 chr1:162531613 UAP1 0.62 7.56 0.42 6.69e-13 Gut microbiome composition (summer); CESC cis rs6582630 0.502 rs1607867 chr12:38385463 C/T cg26384229 chr12:38710491 ALG10B 0.73 11.15 0.57 6.25e-24 Drug-induced liver injury (flucloxacillin); CESC cis rs2066819 1.000 rs11171803 chr12:56718422 T/C cg26714650 chr12:56694279 CS -1.48 -9.9 -0.52 7.03e-20 Psoriasis vulgaris; CESC trans rs11098499 0.863 rs2127823 chr4:120485670 G/T cg25214090 chr10:38739885 LOC399744 0.67 9.07 0.49 2.85e-17 Corneal astigmatism; CESC cis rs1144333 1.000 rs60144605 chr1:76359699 A/C cg22875332 chr1:76189707 ACADM 0.52 5.04 0.3 8.65e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs1124376 1.000 rs9828701 chr3:20149203 A/G cg05072819 chr3:20081367 KAT2B 0.47 5.14 0.3 5.39e-7 Bipolar disorder and schizophrenia; CESC cis rs9814567 0.722 rs13083717 chr3:134348796 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.46 5.71 0.33 3.01e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4523957 0.651 rs7223390 chr17:2085653 T/C cg16513277 chr17:2031491 SMG6 -0.71 -10.17 -0.53 1.04e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg17211192 chr8:82754475 SNX16 -0.58 -7.62 -0.42 4.64e-13 Diastolic blood pressure; CESC cis rs12479064 0.724 rs3792150 chr2:100041849 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -7.01 -0.4 1.98e-11 Chronic sinus infection; CESC cis rs7647973 1.000 rs13096474 chr3:49443081 C/T cg07636037 chr3:49044803 WDR6 -0.71 -10.03 -0.52 2.87e-20 Menarche (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15703646 chr7:100209939 MOSPD3 -0.42 -6.14 -0.35 2.96e-9 Gambling; CESC cis rs8114671 0.967 rs34515766 chr20:33785221 C/G cg06115741 chr20:33292138 TP53INP2 -0.42 -5.11 -0.3 6.06e-7 Height; CESC cis rs12765878 0.934 rs11191841 chr10:105639611 C/T cg11005552 chr10:105648138 OBFC1 -0.38 -5.52 -0.32 8e-8 Coronary artery disease; CESC cis rs9549260 0.620 rs4325427 chr13:41216534 C/T cg21288729 chr13:41239152 FOXO1 0.66 8.68 0.47 4.2e-16 Red blood cell count; CESC cis rs2795502 0.515 rs116848302 chr10:43367783 G/A cg20628663 chr10:43360327 NA 0.57 5.1 0.3 6.44e-7 Blood protein levels; CESC cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg19077165 chr18:44547161 KATNAL2 0.54 8.01 0.44 3.56e-14 Personality dimensions; CESC cis rs30380 0.553 rs152280 chr5:96161942 T/G cg16492584 chr5:96139282 ERAP1 -0.41 -5.62 -0.33 4.9e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7660520 0.524 rs4862100 chr4:183732709 G/T cg09197432 chr4:183729176 NA 0.58 5.59 0.32 5.75e-8 Pediatric autoimmune diseases; CESC cis rs4076764 1.000 rs7540279 chr1:163429970 A/T cg06092702 chr1:163392909 NA -0.37 -5.39 -0.31 1.57e-7 Motion sickness; CESC cis rs7215564 0.822 rs10871488 chr17:78739079 T/C cg11222173 chr17:78748019 RPTOR 0.55 5.04 0.3 8.62e-7 Myopia (pathological); CESC trans rs17685 0.702 rs6960598 chr7:75772991 T/C cg19862616 chr7:65841803 NCRNA00174 0.8 11.44 0.57 6.89e-25 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2243480 0.908 rs4718273 chr7:65216099 G/A cg18252515 chr7:66147081 NA 1.21 11.36 0.57 1.3e-24 Diabetic kidney disease; CESC cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg10523679 chr1:76189770 ACADM -0.65 -7.28 -0.41 3.82e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11098499 0.863 rs36040693 chr4:120477616 A/G cg09307838 chr4:120376055 NA 0.91 12.68 0.61 4e-29 Corneal astigmatism; CESC cis rs1008375 0.966 rs1860599 chr4:17638900 T/C cg02297831 chr4:17616191 MED28 0.54 6.85 0.39 5.05e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg04287289 chr16:89883240 FANCA 0.9 15.27 0.68 3.27e-38 Vitiligo; CESC cis rs4132509 0.793 rs34477525 chr1:243966454 T/A cg21452805 chr1:244014465 NA 0.5 6.25 0.36 1.59e-9 RR interval (heart rate); CESC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg03647317 chr4:187891568 NA 0.37 5.32 0.31 2.17e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs60871478 0.735 rs4721501 chr7:862166 G/T cg05535760 chr7:792225 HEATR2 -0.81 -8.41 -0.46 2.63e-15 Cerebrospinal P-tau181p levels; CESC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg19077165 chr18:44547161 KATNAL2 -0.54 -7.79 -0.43 1.53e-13 Personality dimensions; CESC cis rs9512730 0.527 rs11619722 chr13:27998600 T/C cg08193333 chr13:27998609 GTF3A 0.54 6.35 0.36 9.52e-10 Schizophrenia; CESC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg26939375 chr7:64535504 NA 0.48 6.2 0.36 2.12e-9 Aortic root size; CESC cis rs9583531 0.600 rs6492303 chr13:111356800 G/A cg24331049 chr13:111365604 ING1 0.73 10.7 0.55 1.9e-22 Coronary artery disease; CESC trans rs4308128 0.657 rs272049 chr2:116622022 C/A cg17910586 chr3:52479098 SEMA3G -0.43 -6.04 -0.35 5.13e-9 Suicide attempts in major depressive disorder; CESC cis rs7580658 0.929 rs4150477 chr2:128032546 A/G cg10021288 chr2:128175891 PROC 0.42 6.7 0.38 1.27e-10 Protein C levels; CESC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg01448562 chr3:133502909 NA -0.42 -5.9 -0.34 1.09e-8 Iron status biomarkers; CESC cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg16339924 chr4:17578868 LAP3 0.59 7.41 0.41 1.69e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs67311347 1.000 rs56291770 chr3:40515370 T/C cg24209194 chr3:40518798 ZNF619 0.5 6.15 0.35 2.84e-9 Renal cell carcinoma; CESC cis rs3733585 0.699 rs6449179 chr4:9969117 G/A cg11266682 chr4:10021025 SLC2A9 -0.57 -10.92 -0.56 3.5e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg02725872 chr8:58115012 NA -0.48 -7.47 -0.42 1.14e-12 Developmental language disorder (linguistic errors); CESC cis rs6500395 1.000 rs7195684 chr16:48710750 G/A cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg06456125 chr7:65229604 NA -0.4 -5.58 -0.32 5.82e-8 Aortic root size; CESC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg12463550 chr7:65579703 CRCP -0.53 -6.69 -0.38 1.36e-10 Aortic root size; CESC cis rs62432291 0.681 rs418859 chr6:159649695 A/T cg14500486 chr6:159655392 FNDC1 0.6 6.01 0.35 6.09e-9 Joint mobility (Beighton score); CESC cis rs9908102 0.740 rs733889 chr17:12918118 A/G cg26162695 chr17:12921313 ELAC2 0.56 6.04 0.35 5.13e-9 Schizophrenia; CESC cis rs317689 0.613 rs315112 chr12:69785926 T/A cg20891283 chr12:69753455 YEATS4 0.72 9.58 0.51 7.42e-19 Response to diuretic therapy; CESC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg06873352 chr17:61820015 STRADA 0.73 13.07 0.63 1.78e-30 Prudent dietary pattern; CESC cis rs2204008 0.744 rs66474616 chr12:38461564 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.71 0.38 1.14e-10 Bladder cancer; CESC cis rs1707322 0.964 rs785508 chr1:46527159 G/A cg05343316 chr1:45956843 TESK2 -0.42 -5.05 -0.3 8.16e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6502050 0.835 rs8079389 chr17:80158656 T/G cg23985595 chr17:80112537 CCDC57 -0.4 -6.37 -0.36 8.38e-10 Life satisfaction; CESC cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg05347473 chr6:146136440 FBXO30 -0.57 -7.25 -0.41 4.46e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.33 0.31 2.11e-7 Tonsillectomy; CESC cis rs35110281 0.782 rs2051407 chr21:45079245 T/C cg21573476 chr21:45109991 RRP1B -0.51 -7.14 -0.4 8.91e-12 Mean corpuscular volume; CESC cis rs17039065 0.920 rs17039101 chr4:109434632 C/G cg16022748 chr4:109541635 LOC285456;RPL34 0.67 6.15 0.35 2.81e-9 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg08888203 chr3:10149979 C3orf24 0.52 6.28 0.36 1.38e-9 Alzheimer's disease; CESC cis rs7429990 0.965 rs35199727 chr3:47946708 T/C cg11946769 chr3:48343235 NME6 0.46 5.59 0.32 5.54e-8 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11913104 chr19:13056743 RAD23A 0.59 6.51 0.37 3.85e-10 Gut microbiome composition (summer); CESC cis rs7116495 1.000 rs73539529 chr11:71815596 T/C cg26138937 chr11:71823887 C11orf51 0.86 6.88 0.39 4.18e-11 Severe influenza A (H1N1) infection; CESC cis rs7809950 0.678 rs7790080 chr7:107031322 G/A cg23024343 chr7:107201750 COG5 -0.58 -7.26 -0.41 4.42e-12 Coronary artery disease; CESC cis rs55794721 0.509 rs6699113 chr1:25777743 C/T cg03538708 chr1:25844672 NA -0.41 -6.27 -0.36 1.48e-9 Plateletcrit;Mean corpuscular volume; CESC cis rs6736093 1.000 rs10496439 chr2:112664631 C/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.35 -0.31 1.91e-7 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26531923 chr6:24646364 KIAA0319 -0.47 -6.0 -0.35 6.28e-9 Gut microbiota (bacterial taxa); CESC cis rs9399401 0.667 rs17071756 chr6:142715195 C/T cg04461802 chr6:142623433 GPR126 -0.39 -5.64 -0.33 4.41e-8 Chronic obstructive pulmonary disease; CESC cis rs909674 0.734 rs5757675 chr22:39838892 G/T cg11247378 chr22:39784982 NA -0.59 -8.61 -0.47 6.52e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs710865 0.541 rs4066014 chr1:19555783 A/G cg13387374 chr1:19411106 UBR4 0.47 5.73 0.33 2.7e-8 Brain structure; CESC cis rs7666738 0.830 rs880472 chr4:98922595 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 0.967 rs402191 chr6:167405553 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.89 0.34 1.15e-8 Crohn's disease; CESC cis rs7918232 0.941 rs7907988 chr10:27444344 T/G cg14442939 chr10:27389572 ANKRD26 0.66 6.3 0.36 1.27e-9 Breast cancer; CESC cis rs7084402 1.000 rs12259315 chr10:60266152 T/C cg07615347 chr10:60278583 BICC1 -0.58 -8.92 -0.48 8.11e-17 Refractive error; CESC cis rs826838 1.000 rs826891 chr12:39100824 A/G cg13010199 chr12:38710504 ALG10B -0.4 -5.54 -0.32 7.42e-8 Heart rate; CESC cis rs1670533 1.000 rs7673898 chr4:1056569 C/A cg04106633 chr4:1044584 NA 0.41 5.19 0.3 4.11e-7 Recombination rate (females); CESC cis rs2635047 0.811 rs17785419 chr18:44765469 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -6.27 -0.36 1.48e-9 Educational attainment; CESC cis rs9287719 0.745 rs4997810 chr2:10755540 T/A cg02196655 chr2:10830764 NOL10 -0.37 -5.51 -0.32 8.5e-8 Prostate cancer; CESC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs6502050 0.865 rs8073679 chr17:80155343 G/A cg23985595 chr17:80112537 CCDC57 -0.39 -6.26 -0.36 1.53e-9 Life satisfaction; CESC cis rs858239 0.568 rs6970694 chr7:23250828 T/C cg23682824 chr7:23144976 KLHL7 0.46 5.88 0.34 1.23e-8 Cerebrospinal fluid biomarker levels; CESC cis rs644799 0.862 rs1150361 chr11:95633805 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.6 7.68 0.43 3.1e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00974149 chr17:56296512 MKS1 -0.43 -6.01 -0.35 6.18e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2228479 0.850 rs2302162 chr16:89845287 A/G cg04013166 chr16:89971882 TCF25 0.78 6.68 0.38 1.41e-10 Skin colour saturation; CESC trans rs9650657 0.537 rs11250092 chr8:10786543 A/G cg15556689 chr8:8085844 FLJ10661 0.54 6.55 0.37 2.92e-10 Neuroticism; CESC cis rs644799 0.930 rs3802764 chr11:95514599 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.93 0.39 3.22e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05439191 chr3:9791515 OGG1 0.58 6.11 0.35 3.62e-9 Gut microbiome composition (summer); CESC cis rs3820068 0.580 rs61169376 chr1:16003832 A/G cg17385448 chr1:15911702 AGMAT 0.39 6.22 0.36 1.94e-9 Systolic blood pressure; CESC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg23758822 chr17:41437982 NA 1.03 15.37 0.69 1.52e-38 Menopause (age at onset); CESC cis rs7824557 0.564 rs12547100 chr8:11242632 G/A cg21775007 chr8:11205619 TDH -0.5 -7.41 -0.41 1.66e-12 Retinal vascular caliber; CESC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.21 -0.53 7.17e-21 Alzheimer's disease; CESC cis rs35306767 0.953 rs1106064 chr10:957211 G/A cg26597838 chr10:835615 NA 0.82 9.53 0.51 1.07e-18 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24074884 chr19:17356310 NR2F6 0.46 5.99 0.35 6.71e-9 Gut microbiome composition (summer); CESC cis rs9394438 0.628 rs2153947 chr6:37544930 A/G cg00985040 chr6:37553208 NA -0.33 -5.38 -0.31 1.62e-7 IgG glycosylation; CESC cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg13902645 chr11:5959945 NA -0.68 -8.25 -0.45 7.64e-15 DNA methylation (variation); CESC cis rs2204008 0.837 rs12369089 chr12:38060263 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.64 0.55 3.1e-22 Bladder cancer; CESC cis rs1401999 1.000 rs6443926 chr3:183706630 A/C cg01324343 chr3:183735012 ABCC5 0.64 13.64 0.64 1.94e-32 Anterior chamber depth; CESC cis rs2404602 0.669 rs12438540 chr15:76943213 C/G cg22467129 chr15:76604101 ETFA -0.35 -5.21 -0.3 3.89e-7 Blood metabolite levels; CESC cis rs10791097 0.677 rs11222359 chr11:130730648 A/G cg09137382 chr11:130731461 NA 0.39 5.86 0.34 1.38e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23359810 chr10:51572113 NCOA4 0.39 6.08 0.35 4.07e-9 Gambling; CESC cis rs4955124 0.558 rs12632509 chr3:32024275 T/C cg05935571 chr3:32023257 ZNF860;OSBPL10 1.01 8.09 0.45 2.1e-14 Schizophrenia; CESC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.44 -6.05 -0.35 4.93e-9 Bipolar disorder; CESC cis rs1983891 0.742 rs9369295 chr6:41564026 G/C cg20194872 chr6:41519635 FOXP4 0.44 6.16 0.35 2.74e-9 Prostate cancer; CESC cis rs2295499 0.643 rs12509102 chr4:2710962 G/C cg27239842 chr4:2403781 ZFYVE28 -0.34 -5.82 -0.34 1.69e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs1048238 0.548 rs848217 chr1:16272250 A/G cg22431228 chr1:16359049 CLCNKA 0.46 8.63 0.47 5.65e-16 Systolic blood pressure; CESC cis rs9486719 1.000 rs10457159 chr6:96993139 G/A cg06623918 chr6:96969491 KIAA0776 -0.79 -8.2 -0.45 1.07e-14 Migraine;Coronary artery disease; CESC cis rs1215050 0.818 rs6532703 chr4:98777486 A/T cg05340658 chr4:99064831 C4orf37 0.54 6.42 0.37 6.44e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9326248 0.569 rs4938315 chr11:116731205 C/T cg01368799 chr11:117014884 PAFAH1B2 0.57 5.35 0.31 1.93e-7 Blood protein levels; CESC cis rs9457247 0.967 rs377753 chr6:167389496 A/T cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC cis rs2235642 0.787 rs2235646 chr16:1601287 A/G cg03715980 chr16:1756201 MAPK8IP3 0.39 5.03 0.3 8.87e-7 Coronary artery disease; CESC cis rs826838 0.967 rs7965656 chr12:38807244 G/A cg26384229 chr12:38710491 ALG10B 0.81 13.62 0.64 2.28e-32 Heart rate; CESC cis rs9788682 1.000 rs7181245 chr15:78814389 C/T cg24631222 chr15:78858424 CHRNA5 0.73 9.27 0.49 6.82e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs208520 0.955 rs12202599 chr6:67001573 A/G cg07460842 chr6:66804631 NA 0.77 8.99 0.48 4.98e-17 Exhaled nitric oxide output; CESC cis rs67460515 0.500 rs9822435 chr3:160748068 A/T cg03342759 chr3:160939853 NMD3 -0.5 -6.06 -0.35 4.78e-9 Parkinson's disease; CESC cis rs9303280 0.754 rs3816470 chr17:37985801 A/G cg20243544 chr17:37824526 PNMT 0.52 7.03 0.4 1.74e-11 Self-reported allergy; CESC cis rs7605827 0.930 rs2052435 chr2:15687306 A/T cg19274914 chr2:15703543 NA 0.3 5.39 0.31 1.59e-7 Educational attainment (years of education); CESC cis rs2180341 0.814 rs9321085 chr6:127735361 T/C cg27446573 chr6:127587934 RNF146 0.83 12.03 0.59 6.99e-27 Breast cancer; CESC cis rs60154123 0.730 rs652256 chr1:210465017 T/C cg22029157 chr1:209979665 IRF6 0.48 5.88 0.34 1.21e-8 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13444131 chr19:40322546 DYRK1B 0.5 6.91 0.39 3.61e-11 Fibrinogen levels; CESC cis rs6977660 0.507 rs28402966 chr7:19774469 A/C cg07541023 chr7:19748670 TWISTNB 0.8 7.2 0.4 6.34e-12 Thyroid stimulating hormone; CESC cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg03433033 chr1:76189801 ACADM -0.6 -6.31 -0.36 1.15e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg27286337 chr10:134555280 INPP5A 0.59 6.9 0.39 3.78e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg26874164 chr19:58962979 ZNF324B 0.54 7.55 0.42 6.95e-13 Uric acid clearance; CESC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg08859206 chr1:53392774 SCP2 0.53 6.93 0.39 3.16e-11 Monocyte count; CESC cis rs1215050 0.740 rs804051 chr4:98935935 A/T cg05340658 chr4:99064831 C4orf37 -0.56 -7.47 -0.42 1.16e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs36051895 0.623 rs7025005 chr9:5261794 T/C cg02405213 chr9:5042618 JAK2 -0.52 -6.49 -0.37 4.26e-10 Pediatric autoimmune diseases; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26512406 chr16:28223152 XPO6 0.64 7.58 0.42 5.83e-13 Gut microbiome composition (summer); CESC cis rs907612 0.638 rs11041476 chr11:1875067 C/T cg07277017 chr11:1874093 LSP1 0.35 5.76 0.33 2.29e-8 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; CESC cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg23711669 chr6:146136114 FBXO30 0.97 14.77 0.67 2.05e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs7635838 0.684 rs2594968 chr3:11352442 T/C cg00170343 chr3:11313890 ATG7 0.54 7.66 0.43 3.45e-13 HDL cholesterol; CESC cis rs11997175 0.646 rs7386741 chr8:33769709 A/G ch.8.33884649F chr8:33765107 NA 0.43 5.17 0.3 4.58e-7 Body mass index; CESC cis rs760805 0.900 rs1005733 chr1:25261960 T/A cg22509179 chr1:25234806 RUNX3 -0.69 -10.07 -0.53 2.08e-20 Allergic disease (asthma, hay fever or eczema); CESC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg18305652 chr10:134549665 INPP5A 0.48 6.9 0.39 3.86e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs3733585 0.673 rs6449156 chr4:9956712 G/C cg00071950 chr4:10020882 SLC2A9 -0.72 -11.68 -0.58 1.03e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9611565 0.694 rs2142505 chr22:41820541 A/G cg06481639 chr22:41940642 POLR3H 0.64 6.43 0.37 5.82e-10 Vitiligo; CESC cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg14784868 chr12:69753453 YEATS4 0.84 13.23 0.63 5.07e-31 Blood protein levels; CESC cis rs858239 0.539 rs6971673 chr7:23159523 C/G cg23682824 chr7:23144976 KLHL7 0.54 7.4 0.41 1.79e-12 Cerebrospinal fluid biomarker levels; CESC cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg01017244 chr2:74357527 NA 0.68 9.91 0.52 6.99e-20 Gestational age at birth (maternal effect); CESC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg15445000 chr17:37608096 MED1 0.4 6.54 0.37 3.24e-10 Glomerular filtration rate (creatinine); CESC trans rs35110281 0.776 rs1073522 chr21:45009219 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 7.86 0.43 9.43e-14 Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08389503 chr7:6204983 CYTH3 0.44 6.06 0.35 4.53e-9 Fibrinogen levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13778778 chr20:35808076 C20orf132;RPN2 -0.5 -6.48 -0.37 4.39e-10 Ulcerative colitis; CESC cis rs7605827 0.897 rs10166429 chr2:15514472 A/C cg19274914 chr2:15703543 NA 0.32 5.55 0.32 6.84e-8 Educational attainment (years of education); CESC cis rs870825 0.655 rs35397385 chr4:185639095 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.07 0.4 1.39e-11 Blood protein levels; CESC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg18099408 chr3:52552593 STAB1 -0.32 -5.25 -0.31 3.08e-7 Bipolar disorder; CESC cis rs12410462 0.681 rs114950580 chr1:227673334 G/C cg23173402 chr1:227635558 NA 0.69 5.31 0.31 2.27e-7 Major depressive disorder; CESC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg06634786 chr22:41940651 POLR3H -0.67 -6.82 -0.39 6.3e-11 Vitiligo; CESC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg25072359 chr17:41440525 NA 0.46 6.1 0.35 3.77e-9 Menopause (age at onset); CESC trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg15704280 chr7:45808275 SEPT13 0.88 12.57 0.61 9.61e-29 Height; CESC cis rs9487051 0.604 rs9320282 chr6:109619377 A/G cg12927641 chr6:109611667 NA -0.35 -5.12 -0.3 5.81e-7 Reticulocyte fraction of red cells; CESC cis rs2243480 1.000 rs34933526 chr7:65383199 A/G cg13147721 chr7:65941812 NA -0.85 -8.1 -0.45 2e-14 Diabetic kidney disease; CESC cis rs7259376 0.936 rs2099354 chr19:22539532 C/A cg02657401 chr19:22469223 NA -0.25 -5.05 -0.3 8.16e-7 Menopause (age at onset); CESC cis rs10949834 1.000 rs10949835 chr7:73488922 A/G cg07137043 chr7:73588983 EIF4H -0.68 -5.39 -0.31 1.53e-7 Verbal memory performance (residualized delayed recall change); CESC cis rs57244997 0.860 rs9458425 chr6:162376946 C/T cg17173639 chr6:162384350 PARK2 -0.75 -7.63 -0.42 4.27e-13 Mosquito bite size; CESC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg21951975 chr1:209979733 IRF6 0.62 7.75 0.43 2.01e-13 Cleft lip with or without cleft palate; CESC cis rs7927771 0.832 rs7940536 chr11:47395240 G/A cg18512352 chr11:47633146 NA 0.49 7.01 0.4 2.02e-11 Subjective well-being; CESC cis rs4808199 1.000 rs7258508 chr19:19475469 T/C cg03709012 chr19:19516395 GATAD2A 1.08 12.88 0.62 8.56e-30 Nonalcoholic fatty liver disease; CESC cis rs690037 0.641 rs538525 chr3:16376279 A/G cg23474789 chr3:16306055 DPH3;OXNAD1 0.51 6.89 0.39 4.06e-11 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); CESC cis rs35995292 0.553 rs2392605 chr7:38924670 T/C cg19327137 chr7:38886074 VPS41 0.64 10.39 0.54 1.98e-21 Subjective well-being (multi-trait analysis); CESC trans rs57221529 0.713 rs12521091 chr5:590710 G/T cg25482853 chr8:67687455 SGK3 0.97 9.68 0.51 3.51e-19 Lung disease severity in cystic fibrosis; CESC cis rs7666738 0.830 rs4292342 chr4:98959870 A/T cg03467027 chr4:99064603 C4orf37 0.44 5.43 0.32 1.31e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6570726 0.935 rs452552 chr6:145820781 G/A cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs9457247 0.935 rs1044059 chr6:167369897 C/A cg07741184 chr6:167504864 NA -0.31 -5.47 -0.32 1.03e-7 Crohn's disease; CESC cis rs950776 0.518 rs4886571 chr15:78833758 G/A cg06917634 chr15:78832804 PSMA4 -0.79 -12.1 -0.6 4.1e-27 Sudden cardiac arrest; CESC cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg05340658 chr4:99064831 C4orf37 0.78 11.64 0.58 1.43e-25 Colonoscopy-negative controls vs population controls; CESC cis rs5753618 0.607 rs5753621 chr22:31847647 T/C cg13145458 chr22:31556086 RNF185 -0.5 -5.89 -0.34 1.16e-8 Colorectal cancer; CESC cis rs11098499 0.575 rs907205 chr4:120238664 G/C cg09307838 chr4:120376055 NA 0.79 10.77 0.55 1.17e-22 Corneal astigmatism; CESC cis rs13392177 0.684 rs62185965 chr2:219073779 T/C cg00012203 chr2:219082015 ARPC2 -0.66 -8.2 -0.45 1.01e-14 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs9916302 0.706 rs7503377 chr17:37708841 A/G cg20243544 chr17:37824526 PNMT 0.57 5.56 0.32 6.59e-8 Glomerular filtration rate (creatinine); CESC cis rs4523957 0.890 rs9900379 chr17:2101134 G/A cg16513277 chr17:2031491 SMG6 -0.66 -9.11 -0.49 2.04e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23963070 chr1:1162176 SDF4 0.45 6.01 0.35 5.95e-9 Fibrinogen levels; CESC cis rs6570726 1.000 rs1935615 chr6:145921117 G/T cg05347473 chr6:146136440 FBXO30 0.41 5.55 0.32 6.9e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg19346786 chr7:2764209 NA -0.5 -7.22 -0.41 5.54e-12 Height; CESC cis rs2297440 0.530 rs34533955 chr20:62233020 A/C cg09650180 chr20:62225654 GMEB2 -0.82 -9.27 -0.49 6.91e-18 Glioma;Non-glioblastoma glioma;Glioblastoma; CESC cis rs858239 0.601 rs3735228 chr7:23170427 T/G cg23682824 chr7:23144976 KLHL7 0.54 7.55 0.42 6.83e-13 Cerebrospinal fluid biomarker levels; CESC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg24503407 chr1:205819492 PM20D1 0.45 6.6 0.38 2.26e-10 Prostate cancer; CESC cis rs7772486 0.659 rs9376957 chr6:146011064 C/T cg23711669 chr6:146136114 FBXO30 -0.88 -12.63 -0.61 6.23e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs4919087 0.748 rs1147600 chr10:98981643 T/C cg25902810 chr10:99078978 FRAT1 -0.52 -5.82 -0.34 1.71e-8 Monocyte count; CESC cis rs7089973 0.836 rs1966384 chr10:116627910 G/T cg23260525 chr10:116636907 FAM160B1 0.37 6.3 0.36 1.26e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9611565 0.559 rs5758428 chr22:42106216 G/A cg17376030 chr22:41985996 PMM1 -0.78 -8.43 -0.46 2.23e-15 Vitiligo; CESC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg05863683 chr7:1912471 MAD1L1 0.4 5.89 0.34 1.16e-8 Schizophrenia; CESC cis rs2594989 0.943 rs346072 chr3:11306851 A/G cg00170343 chr3:11313890 ATG7 -0.55 -5.06 -0.3 7.92e-7 Circulating chemerin levels; CESC trans rs1814175 0.541 rs12287397 chr11:49819799 G/A cg03929089 chr4:120376271 NA -0.91 -15.19 -0.68 6.5e-38 Height; CESC cis rs7589342 0.831 rs10169998 chr2:106452253 A/G cg16077055 chr2:106428750 NCK2 0.49 6.83 0.39 5.65e-11 Addiction; CESC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.1 0.53 1.62e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12817154 chr4:864995 GAK 0.48 6.38 0.36 7.73e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05929132 chr15:66586024 DIS3L 0.6 7.22 0.41 5.58e-12 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs11722037 chr4:17683811 G/A cg16339924 chr4:17578868 LAP3 0.49 6.27 0.36 1.44e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02528389 chr5:143550332 YIPF5;KCTD16 0.56 6.13 0.35 3.12e-9 Gut microbiome composition (summer); CESC cis rs593982 0.920 rs4930298 chr11:65448108 T/A cg08755490 chr11:65554678 OVOL1 -1.17 -8.74 -0.47 2.66e-16 Atopic dermatitis; CESC cis rs7665939 1.000 rs72709217 chr4:190113079 C/T cg14840187 chr4:190284988 NA -0.63 -6.2 -0.36 2.12e-9 Amyotrophic lateral sclerosis; CESC cis rs11098499 0.779 rs72918579 chr4:120333222 G/C cg24375607 chr4:120327624 NA 0.47 5.71 0.33 3.03e-8 Corneal astigmatism; CESC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg23708337 chr7:1209742 NA 0.49 5.21 0.3 3.82e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10463316 0.779 rs6861968 chr5:150817725 C/T cg03212797 chr5:150827313 SLC36A1 -0.44 -5.74 -0.33 2.54e-8 Metabolite levels (Pyroglutamine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24117723 chr11:77185398 PAK1 0.59 6.5 0.37 4.03e-10 Gut microbiome composition (summer); CESC cis rs8017423 0.935 rs7154695 chr14:90795705 C/G cg14092571 chr14:90743983 NA -0.53 -7.63 -0.42 4.19e-13 Mortality in heart failure; CESC cis rs10744422 1.000 rs4759355 chr12:123316566 A/G cg25930673 chr12:123319894 HIP1R -0.67 -5.41 -0.32 1.42e-7 Schizophrenia; CESC cis rs12586317 0.553 rs3809448 chr14:35515096 C/T cg05294307 chr14:35346193 BAZ1A -0.57 -5.82 -0.34 1.71e-8 Psoriasis; CESC cis rs763121 0.853 rs2076028 chr22:39150450 G/A cg06022373 chr22:39101656 GTPBP1 0.92 15.32 0.69 2.23e-38 Menopause (age at onset); CESC cis rs367943 0.608 rs4705564 chr5:112980196 G/C cg12552261 chr5:112820674 MCC 0.39 5.03 0.3 8.99e-7 Type 2 diabetes; CESC cis rs4595586 0.545 rs12812959 chr12:39371197 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.51 0.42 8.86e-13 Morning vs. evening chronotype; CESC cis rs9522267 0.535 rs4773392 chr13:112227358 A/G cg10483660 chr13:112241077 NA 0.34 6.09 0.35 3.85e-9 Hepatitis; CESC cis rs295140 0.546 rs295119 chr2:201117944 C/T cg23649088 chr2:200775458 C2orf69 0.46 5.98 0.34 7.23e-9 QT interval; CESC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg18876405 chr7:65276391 NA 0.53 7.32 0.41 3.01e-12 Aortic root size; CESC cis rs11785400 1.000 rs3824208 chr8:143743653 C/G cg10596483 chr8:143751796 JRK 0.43 5.65 0.33 4.1e-8 Schizophrenia; CESC cis rs7551222 0.752 rs12039454 chr1:204542580 C/T cg20240347 chr1:204465584 NA 0.27 5.45 0.32 1.16e-7 Schizophrenia; CESC cis rs7255436 0.965 rs11668346 chr19:8450854 A/T cg16745616 chr19:8428856 ANGPTL4 -0.36 -5.49 -0.32 9.22e-8 HDL cholesterol; CESC cis rs4450131 0.522 rs11245323 chr10:126344624 C/T cg20435097 chr10:126320824 FAM53B 0.29 5.23 0.31 3.43e-7 White blood cell count (basophil); CESC cis rs2073300 0.609 rs6132609 chr20:23400412 A/C cg16736954 chr20:23401023 NAPB 0.77 5.65 0.33 4.24e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9308731 0.591 rs7569300 chr2:111944873 G/A cg04202892 chr2:111875749 ACOXL 0.37 5.17 0.3 4.61e-7 Chronic lymphocytic leukemia; CESC cis rs79349575 0.651 rs4378658 chr17:46993370 G/A cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs4654899 0.802 rs6426648 chr1:21179527 A/G cg05370193 chr1:21551575 ECE1 0.37 5.41 0.32 1.41e-7 Superior frontal gyrus grey matter volume; CESC cis rs826838 1.000 rs1963562 chr12:38662896 C/T cg13010199 chr12:38710504 ALG10B 0.59 8.31 0.45 4.93e-15 Heart rate; CESC trans rs2797160 0.651 rs1343121 chr6:126036184 C/T cg05039488 chr6:79577232 IRAK1BP1 0.53 7.17 0.4 7.49e-12 Endometrial cancer; CESC cis rs28374715 0.528 rs28492932 chr15:41624397 G/C cg20272979 chr15:41787780 ITPKA 0.47 5.57 0.32 6.19e-8 Ulcerative colitis; CESC cis rs753778 0.667 rs6578153 chr8:142209543 C/T cg18755752 chr8:142205143 DENND3 -0.64 -9.53 -0.51 1.04e-18 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs965469 0.545 rs6051846 chr20:3403824 A/G cg25506879 chr20:3388711 C20orf194 0.56 6.93 0.39 3.16e-11 IFN-related cytopenia; CESC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs6500395 0.926 rs11645193 chr16:48594229 C/T cg04672837 chr16:48644449 N4BP1 0.46 5.54 0.32 7.22e-8 Response to tocilizumab in rheumatoid arthritis; CESC trans rs1814175 0.935 rs10839329 chr11:49694206 G/A cg03929089 chr4:120376271 NA -0.87 -13.35 -0.63 1.93e-31 Height; CESC cis rs1707322 0.721 rs11211158 chr1:46132850 C/G cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6963495 0.592 rs114793754 chr7:105152162 G/C cg13798780 chr7:105162888 PUS7 0.76 7.77 0.43 1.79e-13 Bipolar disorder (body mass index interaction); CESC cis rs4974559 0.948 rs3856982 chr4:1328863 C/T cg02980000 chr4:1222292 CTBP1 -0.66 -7.79 -0.43 1.56e-13 Systolic blood pressure; CESC cis rs7264396 0.563 rs7268195 chr20:34339854 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.73 -0.55 1.51e-22 Total cholesterol levels; CESC trans rs1814175 0.645 rs10839382 chr11:49823172 C/T cg11707556 chr5:10655725 ANKRD33B -0.44 -6.32 -0.36 1.09e-9 Height; CESC cis rs9905704 0.801 rs2013182 chr17:56637770 G/A cg12560992 chr17:57184187 TRIM37 -0.62 -7.63 -0.42 4.34e-13 Testicular germ cell tumor; CESC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg10691866 chr7:65817282 TPST1 0.31 5.34 0.31 2e-7 Aortic root size; CESC cis rs11030122 0.702 rs17081 chr11:3987830 A/G cg18678763 chr11:4115507 RRM1 0.46 6.07 0.35 4.38e-9 Mean platelet volume;Platelet distribution width; CESC cis rs7923609 0.934 rs2893919 chr10:65134778 G/A cg01631684 chr10:65280961 REEP3 -0.42 -5.18 -0.3 4.35e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs6748734 1.000 rs6748734 chr2:241837452 A/G cg15164180 chr2:241846931 NA -0.35 -5.21 -0.3 3.77e-7 Urinary metabolites; CESC cis rs9948 0.655 rs62152785 chr2:97459403 A/T cg01990225 chr2:97406019 LMAN2L -0.89 -7.17 -0.4 7.42e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs921968 0.541 rs7574429 chr2:219498759 T/G cg02176678 chr2:219576539 TTLL4 0.47 8.29 0.45 5.7e-15 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11255513 chr11:113644528 ZW10 -0.57 -6.47 -0.37 4.66e-10 Gut microbiome composition (summer); CESC cis rs2066819 1.000 rs2629447 chr12:56700809 G/A cg26714650 chr12:56694279 CS 1.28 15.86 0.7 2.7e-40 Psoriasis vulgaris; CESC cis rs539096 0.566 rs3011220 chr1:44308867 A/G cg13606994 chr1:44402422 ARTN -0.36 -5.55 -0.32 6.9e-8 Intelligence (multi-trait analysis); CESC cis rs1801251 1.000 rs1044480 chr2:233633736 A/G cg08000102 chr2:233561755 GIGYF2 0.65 9.21 0.49 1.01e-17 Coronary artery disease; CESC cis rs11098499 0.909 rs28555550 chr4:120211040 C/G cg09307838 chr4:120376055 NA 0.88 11.91 0.59 1.75e-26 Corneal astigmatism; CESC cis rs2070488 0.775 rs4679066 chr3:38568527 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.78 -12.87 -0.62 9.13e-30 Electrocardiographic conduction measures; CESC cis rs8072100 0.870 rs10432035 chr17:45624913 G/C cg08085267 chr17:45401833 C17orf57 0.42 5.37 0.31 1.74e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2337406 0.714 rs8022729 chr14:107225161 C/T cg23076370 chr14:107095027 NA 0.55 5.82 0.34 1.68e-8 Alzheimer's disease (late onset); CESC cis rs72781680 0.593 rs72797817 chr2:24350569 A/G cg06627628 chr2:24431161 ITSN2 -0.68 -6.64 -0.38 1.76e-10 Lymphocyte counts; CESC cis rs2108622 0.727 rs3093193 chr19:15991914 C/G cg13772218 chr19:15982569 NA 0.31 6.07 0.35 4.46e-9 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs644799 1.000 rs586238 chr11:95560371 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.29 0.5 5.89e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4253772 0.591 rs9615348 chr22:46729338 C/G cg10541313 chr22:46663664 TTC38 0.73 5.21 0.3 3.86e-7 LDL cholesterol;Cholesterol, total; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15915129 chr11:124933008 SLC37A2 0.46 6.12 0.35 3.39e-9 Systemic lupus erythematosus; CESC cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg12365402 chr11:9010492 NRIP3 -0.42 -7.18 -0.4 7.05e-12 Hemoglobin concentration; CESC cis rs1707322 0.963 rs4660900 chr1:46419605 T/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7044106 0.762 rs10984974 chr9:123421556 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 12.73 0.62 2.71e-29 Hip circumference adjusted for BMI; CESC cis rs55871839 0.547 rs3780001 chr8:59872615 G/T cg07426533 chr8:59803705 TOX -0.45 -5.8 -0.34 1.88e-8 Pneumonia; CESC cis rs8141529 0.748 rs6005936 chr22:29289250 T/C cg02153584 chr22:29168773 CCDC117 0.58 7.78 0.43 1.5700000000000001e-13 Lymphocyte counts; CESC trans rs61931739 0.500 rs28624237 chr12:34457171 G/T cg13010199 chr12:38710504 ALG10B 0.48 6.28 0.36 1.38e-9 Morning vs. evening chronotype; CESC cis rs6430585 0.583 rs3754689 chr2:136590746 C/T cg07169764 chr2:136633963 MCM6 1.18 17.34 0.73 1.59e-45 Corneal structure; CESC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg10295955 chr4:187884368 NA -1.04 -21.24 -0.79 3.96e-59 Lobe attachment (rater-scored or self-reported); CESC trans rs11039798 0.588 rs6485891 chr11:48612024 T/A cg15704280 chr7:45808275 SEPT13 0.61 6.29 0.36 1.32e-9 Axial length; CESC cis rs12477438 0.520 rs6542869 chr2:99783403 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.91 15.64 0.69 1.66e-39 Chronic sinus infection; CESC trans rs1814175 0.817 rs1996982 chr11:49972619 G/T cg03929089 chr4:120376271 NA -0.93 -16.32 -0.71 6.51e-42 Height; CESC cis rs7216064 1.000 rs9912770 chr17:65868233 C/T cg07042672 chr17:66097459 LOC651250 -0.57 -6.57 -0.37 2.69e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2832191 0.933 rs2832236 chr21:30547602 C/T cg08807101 chr21:30365312 RNF160 -0.57 -7.58 -0.42 5.96e-13 Dental caries; CESC cis rs897984 0.644 rs73524556 chr16:30823162 G/A cg02466173 chr16:30829666 NA -0.59 -11.47 -0.58 5.58e-25 Dementia with Lewy bodies; CESC trans rs17536732 0.685 rs80229139 chr4:162856305 T/A cg12177677 chr2:158300475 CYTIP -0.63 -6.2 -0.36 2.17e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs858239 0.601 rs4440529 chr7:23168751 G/C cg23682824 chr7:23144976 KLHL7 0.54 7.37 0.41 2.14e-12 Cerebrospinal fluid biomarker levels; CESC cis rs1448094 0.817 rs10863122 chr12:86346047 T/C cg02569458 chr12:86230093 RASSF9 0.39 5.64 0.33 4.25e-8 Major depressive disorder; CESC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.82 -0.34 1.73e-8 Parkinson's disease; CESC cis rs7666738 0.570 rs10032272 chr4:99095601 T/C cg05340658 chr4:99064831 C4orf37 0.63 8.46 0.46 1.84e-15 Colonoscopy-negative controls vs population controls; CESC cis rs17253792 0.822 rs2274075 chr14:56096731 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs9303280 0.747 rs1453559 chr17:38020419 T/C cg19468946 chr17:37922297 IKZF3 -0.4 -5.47 -0.32 1.05e-7 Self-reported allergy; CESC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.16e-7 Aortic root size; CESC cis rs4629710 0.592 rs11154622 chr6:131547578 C/T cg12606694 chr6:131520996 AKAP7 0.46 5.66 0.33 3.86e-8 Multiple myeloma (IgH translocation); CESC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg18876405 chr7:65276391 NA -0.53 -7.27 -0.41 4.11e-12 Aortic root size; CESC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 12.47 0.61 2.14e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6500602 0.647 rs1641868 chr16:4594503 G/C cg08645402 chr16:4508243 NA 0.49 7.81 0.43 1.31e-13 Schizophrenia; CESC cis rs2576037 0.526 rs564113 chr18:44364389 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -7.45 -0.42 1.33e-12 Personality dimensions; CESC cis rs7084402 0.967 rs1658447 chr10:60313174 G/A cg07615347 chr10:60278583 BICC1 0.61 9.59 0.51 7.04e-19 Refractive error; CESC cis rs6580649 0.883 rs4760621 chr12:48561262 A/G cg05342945 chr12:48394962 COL2A1 -0.5 -5.93 -0.34 9.25e-9 Lung cancer; CESC cis rs8180040 0.726 rs1463393 chr3:46994987 G/A cg27129171 chr3:47204927 SETD2 -0.63 -8.95 -0.48 6.47e-17 Colorectal cancer; CESC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03576123 chr11:487126 PTDSS2 1.1 10.95 0.56 2.87e-23 Body mass index; CESC cis rs11048434 0.687 rs12814670 chr12:9060025 C/T cg23795048 chr12:9217529 LOC144571 0.37 5.8 0.34 1.87e-8 Sjögren's syndrome; CESC cis rs6580649 1.000 rs7132668 chr12:48405860 C/T cg24011408 chr12:48396354 COL2A1 0.43 5.45 0.32 1.15e-7 Lung cancer; CESC cis rs460214 0.539 rs55819392 chr21:40038207 G/A cg05519781 chr21:40033154 ERG -0.46 -5.57 -0.32 6.13e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs9915657 0.933 rs4793272 chr17:70139257 A/T cg09344028 chr17:70110421 NA 0.32 6.02 0.35 5.66e-9 Thyroid hormone levels; CESC cis rs17376456 0.825 rs10214278 chr5:93237679 C/T cg25358565 chr5:93447407 FAM172A -1.07 -9.7 -0.51 3.21e-19 Diabetic retinopathy; CESC cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg13628971 chr7:2884303 GNA12 0.41 5.46 0.32 1.11e-7 Height; CESC trans rs11098499 0.866 rs13125526 chr4:120288019 G/A cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs7582720 1.000 rs72936846 chr2:203774734 G/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs2635047 0.713 rs28666933 chr18:44762408 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.64 0.33 4.37e-8 Educational attainment; CESC cis rs748404 0.697 rs564946 chr15:43556272 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.83 0.43 1.19e-13 Lung cancer; CESC cis rs2760061 0.583 rs708113 chr1:228192753 T/A cg02753203 chr1:228287806 NA 0.72 11.27 0.57 2.57e-24 Diastolic blood pressure; CESC cis rs1185460 0.967 rs1184902 chr11:118945337 A/G cg01677386 chr11:118938358 VPS11 -0.44 -5.4 -0.32 1.45e-7 Coronary artery disease; CESC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg18225595 chr11:63971243 STIP1 0.55 5.41 0.32 1.39e-7 Mean platelet volume; CESC cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg24308560 chr3:49941425 MST1R -0.55 -7.61 -0.42 4.87e-13 Body mass index; CESC cis rs28489187 0.617 rs233112 chr1:85785751 C/T cg16011679 chr1:85725395 C1orf52 -0.43 -5.3 -0.31 2.46e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs11098499 0.820 rs6829903 chr4:120506884 C/T cg24375607 chr4:120327624 NA 0.46 5.48 0.32 1.01e-7 Corneal astigmatism; CESC cis rs1728785 1.000 rs1170439 chr16:68608511 T/C cg02972257 chr16:68554789 NA -0.61 -6.93 -0.39 3.25e-11 Ulcerative colitis; CESC cis rs9811920 0.809 rs13059754 chr3:99678490 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.44 -5.65 -0.33 4.05e-8 Axial length; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg00917603 chr5:140209956 PCDHA6;PCDHA2;PCDHA1;PCDHA5;PCDHA3;PCDHA4 0.41 6.23 0.36 1.85e-9 Recombination measurement; CESC trans rs74054849 0.850 rs72879500 chr1:16033853 G/A cg06826283 chr7:600452 PRKAR1B 0.69 6.1 0.35 3.76e-9 Alcoholic chronic pancreatitis; CESC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg14664628 chr15:75095509 CSK -0.56 -7.57 -0.42 6.12e-13 Breast cancer; CESC cis rs8114671 0.562 rs4911161 chr20:33402231 C/T cg08999081 chr20:33150536 PIGU 0.4 5.67 0.33 3.74e-8 Height; CESC cis rs2228479 0.717 rs9282682 chr16:89805794 A/G cg00800038 chr16:89945340 TCF25 -0.61 -6.18 -0.36 2.38e-9 Skin colour saturation; CESC cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg00376283 chr12:123451042 ABCB9 0.72 10.03 0.52 2.88e-20 Platelet count; CESC cis rs12541635 0.934 rs2115703 chr8:107045935 C/G cg10147462 chr8:107024639 NA 0.42 5.97 0.34 7.51e-9 Age of smoking initiation; CESC cis rs2228479 0.541 rs13335395 chr16:89952843 T/A cg04013166 chr16:89971882 TCF25 0.72 8.57 0.47 8.47e-16 Skin colour saturation; CESC cis rs2635047 1.000 rs2684841 chr18:44724262 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.49 6.74 0.38 1.01e-10 Educational attainment; CESC cis rs2050392 0.624 rs303435 chr10:30731491 T/C cg18806716 chr10:30721971 MAP3K8 -0.62 -9.31 -0.5 5.02e-18 Inflammatory bowel disease; CESC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg25072359 chr17:41440525 NA 0.5 6.77 0.38 8.41e-11 Menopause (age at onset); CESC cis rs11190604 1.000 rs3793771 chr10:102222957 C/G cg07080220 chr10:102295463 HIF1AN 0.55 5.6 0.33 5.35e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs8076336 1 rs8076336 chr17:18212614 A/C cg16794390 chr17:18148240 FLII 0.41 7.04 0.4 1.65e-11 Parental longevity (combined parental age at death); CESC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg18404041 chr3:52824283 ITIH1 -0.35 -5.99 -0.35 6.8e-9 Electroencephalogram traits; CESC cis rs7210086 0.768 rs72849445 chr17:70637985 T/G cg04206342 chr17:70636940 NA -0.31 -6.09 -0.35 4.05e-9 Ulcerative colitis; CESC cis rs2204008 0.618 rs8186932 chr12:38338386 G/A cg26384229 chr12:38710491 ALG10B -0.45 -5.82 -0.34 1.72e-8 Bladder cancer; CESC cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.81 11.33 0.57 1.59e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs5753618 0.583 rs2273251 chr22:31843567 G/C cg13145458 chr22:31556086 RNF185 -0.51 -6.04 -0.35 5.17e-9 Colorectal cancer; CESC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg06219351 chr7:158114137 PTPRN2 -0.44 -6.86 -0.39 4.87e-11 Calcium levels; CESC cis rs6032067 0.777 rs34916007 chr20:43782952 T/G cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.89e-7 Blood protein levels; CESC cis rs941408 1.000 rs2260416 chr19:2796355 G/A cg06609049 chr19:2785107 THOP1 0.71 10.27 0.53 4.74e-21 Total cholesterol levels; CESC cis rs317689 0.876 rs547332 chr12:69743639 C/G cg20891283 chr12:69753455 YEATS4 0.66 8.34 0.46 4.23e-15 Response to diuretic therapy; CESC cis rs9814567 0.964 rs6772406 chr3:134210183 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.98 -0.34 7.11e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg08736216 chr1:53307985 ZYG11A -0.38 -6.25 -0.36 1.65e-9 Monocyte count; CESC cis rs924607 0.966 rs1709554 chr5:637443 A/G cg09021430 chr5:549028 NA -0.39 -6.88 -0.39 4.32e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03272279 chr8:74791249 UBE2W 0.68 7.77 0.43 1.76e-13 Gut microbiome composition (summer); CESC trans rs61931739 0.500 rs3924704 chr12:34557833 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.67 0.55 2.39e-22 Morning vs. evening chronotype; CESC cis rs561341 1.000 rs561341 chr17:30316385 T/G cg23018236 chr17:30244563 NA -0.52 -5.1 -0.3 6.39e-7 Hip circumference adjusted for BMI; CESC trans rs4589258 0.737 rs7110548 chr11:90397761 A/G cg04115680 chr7:75889229 SRRM3 0.34 5.99 0.35 6.67e-9 Intelligence (multi-trait analysis); CESC cis rs965469 0.779 rs6051693 chr20:3244449 T/G cg25506879 chr20:3388711 C20orf194 -0.51 -5.57 -0.32 6.1e-8 IFN-related cytopenia; CESC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg06456125 chr7:65229604 NA -0.39 -5.06 -0.3 7.77e-7 Aortic root size; CESC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg11890956 chr21:40555474 PSMG1 1.17 21.56 0.8 3.08e-60 Cognitive function; CESC cis rs826838 0.967 rs980572 chr12:39127673 A/C cg13010199 chr12:38710504 ALG10B 0.43 5.73 0.33 2.7e-8 Heart rate; CESC cis rs17376456 0.825 rs17374166 chr5:93238655 T/C cg25358565 chr5:93447407 FAM172A 1.1 10.58 0.54 4.84e-22 Diabetic retinopathy; CESC cis rs9303401 1.000 rs6503877 chr17:56841948 C/T cg12560992 chr17:57184187 TRIM37 0.49 5.54 0.32 7.42e-8 Cognitive test performance; CESC cis rs9905704 0.647 rs2108435 chr17:57102133 T/C cg12560992 chr17:57184187 TRIM37 -0.66 -8.39 -0.46 2.97e-15 Testicular germ cell tumor; CESC cis rs9863 0.828 rs11057412 chr12:124489142 G/C cg00084347 chr12:124393913 DNAH10 0.26 5.11 0.3 6.2e-7 White blood cell count; CESC cis rs2835872 0.733 rs1787400 chr21:39038217 G/C cg06728970 chr21:39037746 KCNJ6 0.3 5.59 0.32 5.72e-8 Electroencephalographic traits in alcoholism; CESC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg19346786 chr7:2764209 NA -0.5 -7.17 -0.4 7.34e-12 Height; CESC cis rs9487051 0.735 rs1761608 chr6:109517706 G/A cg01475377 chr6:109611718 NA -0.37 -5.52 -0.32 8.15e-8 Reticulocyte fraction of red cells; CESC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs67311347 1.000 rs73080137 chr3:40516412 A/G cg01475735 chr3:40494733 NA -0.41 -5.14 -0.3 5.28e-7 Renal cell carcinoma; CESC cis rs6545883 0.859 rs2694644 chr2:61604856 A/T cg15711740 chr2:61764176 XPO1 0.4 5.03 0.3 9.13e-7 Tuberculosis; CESC cis rs1707322 0.721 rs10890341 chr1:46147240 C/A cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6912958 0.754 rs4587143 chr6:88292291 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.52 -0.37 3.6e-10 Monocyte percentage of white cells; CESC cis rs10979 0.965 rs9390109 chr6:143892806 T/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.21 -0.49 1.01e-17 Hypospadias; CESC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg26314531 chr2:26401878 FAM59B 0.76 7.54 0.42 7.31e-13 Gut microbiome composition (summer); CESC cis rs11509880 0.606 rs11971133 chr7:12256548 T/C cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.36e-7 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14529598 chr4:8098851 ABLIM2 0.39 6.13 0.35 3.15e-9 Fibrinogen levels; CESC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.04 10.24 0.53 6.17e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8082590 1 rs8082590 chr17:17958402 G/A cg09796270 chr17:17721594 SREBF1 -0.38 -5.12 -0.3 5.97e-7 Schizophrenia; CESC cis rs15676 0.853 rs2259043 chr9:131607921 A/G cg00228799 chr9:131580591 ENDOG 0.44 5.48 0.32 9.79e-8 Blood metabolite levels; CESC cis rs2070488 0.965 rs4679060 chr3:38536261 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.95 -17.92 -0.74 1.34e-47 Electrocardiographic conduction measures; CESC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg22963979 chr7:1858916 MAD1L1 -0.39 -5.42 -0.32 1.37e-7 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs11729753 chr4:98803267 T/A cg17366294 chr4:99064904 C4orf37 0.58 8.12 0.45 1.73e-14 Colonoscopy-negative controls vs population controls; CESC cis rs16867321 0.627 rs2194687 chr2:181577170 G/A cg23363182 chr2:181467187 NA 0.45 6.6 0.38 2.21e-10 Obesity; CESC cis rs17125944 0.572 rs79312783 chr14:53250296 A/T cg13660082 chr14:53194042 PSMC6 -0.67 -5.97 -0.34 7.59e-9 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00041467 chr2:122494276 MKI67IP 0.58 6.63 0.38 1.91e-10 Gut microbiome composition (summer); CESC cis rs2455799 0.552 rs1472697 chr3:15750268 G/A cg09340198 chr3:15902540 ANKRD28 -0.33 -5.15 -0.3 5.13e-7 Mean platelet volume; CESC cis rs7224314 1.000 rs62084076 chr17:65383102 G/A cg01507342 chr17:65387096 PITPNC1 -0.46 -5.6 -0.33 5.31e-8 Diisocyanate-induced asthma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17378273 chr11:45169082 PRDM11 -0.45 -6.28 -0.36 1.39e-9 Gut microbiota (bacterial taxa); CESC cis rs870825 0.616 rs1401358 chr4:185640057 C/T cg04058563 chr4:185651563 MLF1IP 0.63 7.34 0.41 2.68e-12 Blood protein levels; CESC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg08470875 chr2:26401718 FAM59B -0.47 -5.19 -0.3 4.23e-7 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02400751 chr11:74459640 RNF169 -0.44 -6.02 -0.35 5.69e-9 Asthma; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07203573 chr17:73201765 NUP85 -0.52 -6.34 -0.36 9.94e-10 Ulcerative colitis; CESC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg00129232 chr17:37814104 STARD3 0.59 7.98 0.44 4.33e-14 Glomerular filtration rate (creatinine); CESC trans rs11148252 0.595 rs4884522 chr13:53053768 C/A cg18335740 chr13:41363409 SLC25A15 0.56 7.62 0.42 4.45e-13 Lewy body disease; CESC cis rs4253772 0.591 rs6008538 chr22:46685963 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.78 8.9 0.48 8.95e-17 LDL cholesterol;Cholesterol, total; CESC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg12463550 chr7:65579703 CRCP -0.5 -6.46 -0.37 4.91e-10 Aortic root size; CESC cis rs9911578 0.740 rs368243 chr17:56708979 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.43 5.76 0.33 2.31e-8 Intelligence (multi-trait analysis); CESC cis rs2832191 0.646 rs2832214 chr21:30517127 C/T cg24692254 chr21:30365293 RNF160 -0.56 -7.08 -0.4 1.32e-11 Dental caries; CESC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg04772025 chr11:68637568 NA 0.52 6.06 0.35 4.6e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg18350739 chr11:68623251 NA -0.45 -6.5 -0.37 3.89e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3026101 0.671 rs1071705 chr17:5290033 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.8 0.34 1.9e-8 Body mass index; CESC cis rs7129220 0.588 rs60257382 chr11:10122172 C/T cg01453529 chr11:10209919 SBF2 -0.48 -5.38 -0.31 1.67e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs6444746 1.000 rs6444746 chr3:193495155 A/G cg22553634 chr3:193489233 NA -0.42 -5.49 -0.32 9.61e-8 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); CESC cis rs17125944 0.686 rs77625717 chr14:53336544 T/C cg00686598 chr14:53173677 PSMC6 0.94 6.6 0.38 2.19e-10 Alzheimer's disease (late onset); CESC cis rs2066819 1.000 rs11575234 chr12:56744276 C/G cg26734620 chr12:56694298 CS 0.88 8.73 0.47 2.85e-16 Psoriasis vulgaris; CESC trans rs2764766 0.721 rs245192 chr5:127188220 C/T cg15764593 chr10:829463 NA -0.4 -6.19 -0.36 2.33e-9 Schizophrenia; CESC cis rs4727027 0.782 rs10245343 chr7:148796333 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 5.77 0.33 2.25e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1707322 0.752 rs4607935 chr1:46117161 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.12 0.4 1.04e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 6.01 0.35 5.99e-9 Personality dimensions; CESC cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg15485101 chr11:133734466 NA 0.41 6.65 0.38 1.66e-10 Childhood ear infection; CESC cis rs6547741 1.000 rs6706610 chr2:27778091 G/A cg27432699 chr2:27873401 GPN1 0.49 6.86 0.39 4.85e-11 Oral cavity cancer; CESC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.67 0.33 3.7e-8 Bipolar disorder; CESC cis rs78707713 0.841 rs10998780 chr10:71201735 A/T cg12610070 chr10:71211762 TSPAN15 -0.36 -6.41 -0.37 6.68e-10 Venous thromboembolism; CESC cis rs11098499 0.909 rs11723757 chr4:120299669 C/T cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs1691799 0.867 rs1183274 chr12:66732057 C/G cg16791601 chr12:66731901 HELB -0.75 -12.95 -0.62 4.83e-30 White blood cell count (basophil); CESC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.75e-12 Tonsillectomy; CESC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs561341 0.941 rs112569713 chr17:30271738 C/T cg27661571 chr11:113659931 NA -0.71 -7.27 -0.41 4.13e-12 Hip circumference adjusted for BMI; CESC cis rs1538970 0.816 rs34673142 chr1:45985561 G/A cg05343316 chr1:45956843 TESK2 0.92 12.54 0.61 1.2e-28 Platelet count; CESC cis rs7216064 1.000 rs4271626 chr17:65930133 G/A cg07042672 chr17:66097459 LOC651250 -0.55 -5.96 -0.34 8.12e-9 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7772486 0.875 rs2814872 chr6:146310234 T/C cg05347473 chr6:146136440 FBXO30 0.56 7.37 0.41 2.14e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6439153 0.933 rs900381 chr3:128713455 C/G cg25356066 chr3:128598488 ACAD9 0.51 6.57 0.37 2.65e-10 Pneumococcal bacteremia; CESC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg13114125 chr14:105738426 BRF1 -0.78 -10.03 -0.52 2.81e-20 Mean platelet volume;Platelet distribution width; CESC cis rs12541635 0.966 rs4734895 chr8:107002604 A/G cg10147462 chr8:107024639 NA 0.41 5.69 0.33 3.3e-8 Age of smoking initiation; CESC cis rs9291683 0.538 rs11727199 chr4:10036190 C/T cg00071950 chr4:10020882 SLC2A9 0.83 14.43 0.66 3.23e-35 Bone mineral density; CESC cis rs950027 0.620 rs872192 chr15:45614502 A/G cg21132104 chr15:45694354 SPATA5L1 0.68 8.67 0.47 4.44e-16 Response to fenofibrate (adiponectin levels); CESC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.898 rs6712524 chr2:24083925 T/C cg08917208 chr2:24149416 ATAD2B 0.92 8.46 0.46 1.78e-15 Lymphocyte counts; CESC cis rs651907 0.514 rs34301719 chr3:101417993 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 5.91 0.34 1.03e-8 Colorectal cancer; CESC cis rs10870270 1.000 rs11146338 chr10:133770291 C/G cg17892150 chr10:133769511 PPP2R2D -0.86 -12.56 -0.61 1.08e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs17826219 0.636 rs79565452 chr17:29142841 T/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.47e-7 Body mass index; CESC cis rs763014 0.966 rs4144003 chr16:645968 C/T cg07256732 chr16:621771 PIGQ -0.3 -5.1 -0.3 6.42e-7 Height; CESC cis rs1348850 0.918 rs4893966 chr2:178470138 A/G cg22681709 chr2:178499509 PDE11A -0.37 -5.35 -0.31 1.89e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs45535039 0.961 rs7120073 chr11:119112898 T/C cg16724696 chr11:118992527 HINFP 0.43 5.29 0.31 2.51e-7 Plateletcrit; CESC cis rs3820928 0.874 rs1917122 chr2:227835681 C/T cg11843606 chr2:227700838 RHBDD1 -0.45 -5.77 -0.33 2.22e-8 Pulmonary function; CESC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg02034447 chr16:89574710 SPG7 0.47 5.99 0.35 6.82e-9 Multiple myeloma (IgH translocation); CESC cis rs17666538 0.585 rs1669615 chr8:616665 T/C cg02524346 chr8:600233 NA 0.85 6.12 0.35 3.39e-9 IgG glycosylation; CESC cis rs3981351 0.797 rs61866461 chr10:115454862 C/A cg24846397 chr10:115438155 CASP7 -0.36 -5.13 -0.3 5.49e-7 Obesity-related traits; CESC cis rs7267979 0.903 rs6115118 chr20:25246734 G/A cg08601574 chr20:25228251 PYGB 0.42 5.9 0.34 1.12e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs10504229 0.639 rs112926738 chr8:58054939 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -6.75 -0.38 9.05e-11 Developmental language disorder (linguistic errors); CESC cis rs7692995 1.000 rs73098845 chr4:17940718 C/A cg08925142 chr4:18023851 LCORL -0.46 -5.32 -0.31 2.26e-7 Height; CESC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 13.5 0.64 6.04e-32 Platelet count; CESC cis rs3617 0.573 rs4687680 chr3:52907372 G/A cg07507251 chr3:52567010 NT5DC2 0.33 5.44 0.32 1.19e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.94 0.59 1.43e-26 Alzheimer's disease; CESC cis rs1008375 1.000 rs4698648 chr4:17692715 C/G cg16339924 chr4:17578868 LAP3 0.6 7.44 0.42 1.45e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs116095464 0.558 rs60251075 chr5:245292 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.63 -0.47 5.66e-16 Breast cancer; CESC cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg02079420 chr8:82753780 SNX16 0.57 7.65 0.43 3.67e-13 Diastolic blood pressure; CESC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg08888203 chr3:10149979 C3orf24 0.5 6.02 0.35 5.84e-9 Alzheimer's disease; CESC cis rs16973500 1.000 rs16973500 chr16:71965196 C/T cg09427745 chr16:71932006 KIAA0174 -0.52 -5.33 -0.31 2.13e-7 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg06970220 chr1:156163860 SLC25A44 0.38 5.25 0.31 3.16e-7 Testicular germ cell tumor; CESC cis rs2952156 0.920 rs1565920 chr17:37831613 G/A cg00129232 chr17:37814104 STARD3 -0.78 -10.99 -0.56 2.12e-23 Asthma; CESC cis rs7089973 0.604 rs11196936 chr10:116588630 C/T cg23260525 chr10:116636907 FAM160B1 0.4 7.19 0.4 6.76e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7560272 0.501 rs11894953 chr2:73964631 A/G cg20560298 chr2:73613845 ALMS1 -0.41 -5.66 -0.33 3.97e-8 Schizophrenia; CESC cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.17 0.3 4.54e-7 Colonoscopy-negative controls vs population controls; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg16714605 chr19:10765132 ILF3;LOC147727 0.44 6.16 0.35 2.62e-9 Breast cancer;Type 2 diabetes; CESC cis rs208520 0.690 rs4710564 chr6:66823478 A/G cg07460842 chr6:66804631 NA 0.92 10.96 0.56 2.59e-23 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12177922 chr1:154245232 HAX1 0.57 7.3 0.41 3.34e-12 Gut microbiome composition (summer); CESC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.87 7.6 0.42 5.06e-13 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02051553 chr1:10044519 NMNAT1 -0.59 -7.06 -0.4 1.48e-11 Gut microbiome composition (summer); CESC cis rs60154123 0.505 rs1319435 chr1:210047618 C/T cg21951975 chr1:209979733 IRF6 -0.58 -6.27 -0.36 1.47e-9 Coronary artery disease; CESC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg00310523 chr12:86230176 RASSF9 0.38 5.9 0.34 1.11e-8 Major depressive disorder; CESC cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg04972856 chr6:88032051 C6orf162;GJB7 0.35 5.74 0.33 2.6e-8 Monocyte percentage of white cells; CESC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg08470875 chr2:26401718 FAM59B -0.48 -5.21 -0.3 3.8e-7 Gut microbiome composition (summer); CESC cis rs2228479 1.000 rs62052213 chr16:89991963 C/T cg00800038 chr16:89945340 TCF25 -0.92 -7.39 -0.41 1.97e-12 Skin colour saturation; CESC trans rs7039247 0.659 rs12352824 chr9:1267148 C/T cg04148091 chr16:81348876 GAN 0.45 6.04 0.35 5.13e-9 Stem cell factor levels; CESC cis rs2455799 0.613 rs3924773 chr3:15796853 G/A cg09340198 chr3:15902540 ANKRD28 -0.33 -5.16 -0.3 4.94e-7 Mean platelet volume; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg08052428 chr9:135996421 RALGDS 0.47 6.18 0.35 2.4e-9 Obesity-related traits; CESC cis rs11098499 0.954 rs7437420 chr4:120312903 A/G cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10802521 chr3:52805072 NEK4 0.57 6.26 0.36 1.53e-9 Gut microbiome composition (summer); CESC cis rs7193541 0.694 rs8061942 chr16:74691362 C/T cg01733217 chr16:74700730 RFWD3 1.05 20.24 0.78 1.06e-55 Multiple myeloma; CESC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.46 -5.63 -0.33 4.62e-8 Tuberculosis; CESC cis rs533581 0.873 rs555191 chr16:88978850 C/T cg16701003 chr16:89028210 CBFA2T3 0.6 8.5 0.46 1.41e-15 Social autistic-like traits; CESC cis rs7216064 1.000 rs8071463 chr17:65938655 C/T cg12091567 chr17:66097778 LOC651250 0.69 7.54 0.42 7.42e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs734999 0.545 rs28690427 chr1:2571823 A/G cg20673091 chr1:2541236 MMEL1 -0.48 -8.03 -0.44 3.11e-14 Ulcerative colitis; CESC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.14 -0.4 9.22e-12 Personality dimensions; CESC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.18 -0.3 4.46e-7 Bipolar disorder; CESC cis rs748404 0.604 rs2278857 chr15:43632549 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.56 8.76 0.47 2.39e-16 Lung cancer; CESC cis rs9549367 0.756 rs9549702 chr13:113881944 T/G cg00898013 chr13:113819073 PROZ -0.52 -7.32 -0.41 2.88e-12 Platelet distribution width; CESC cis rs7044106 0.734 rs12553070 chr9:123485266 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.34 5.47 0.32 1.06e-7 Hip circumference adjusted for BMI; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09212610 chr15:90892496 GABARAPL3 0.52 7.32 0.41 3.05e-12 Fibrinogen levels; CESC cis rs7824557 0.603 rs2246606 chr8:11219334 G/A cg21775007 chr8:11205619 TDH 0.56 7.98 0.44 4.53e-14 Retinal vascular caliber; CESC cis rs7818345 0.967 rs4391454 chr8:19275653 T/C cg11303988 chr8:19266685 CSGALNACT1 0.34 6.19 0.36 2.31e-9 Language performance in older adults (adjusted for episodic memory); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04343394 chr6:10695072 C6orf52;PAK1IP1 0.56 6.55 0.37 3.04e-10 Gut microbiome composition (summer); CESC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg02569458 chr12:86230093 RASSF9 -0.42 -6.48 -0.37 4.48e-10 Major depressive disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04100724 chr12:92539208 BTG1 0.5 6.68 0.38 1.42e-10 Gut microbiota (bacterial taxa); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16924120 chr12:118814149 SUDS3 -0.46 -6.66 -0.38 1.58e-10 Gambling; CESC cis rs6674176 0.597 rs4031031 chr1:44393533 C/T cg13606994 chr1:44402422 ARTN -0.41 -6.5 -0.37 3.91e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25851803 chr17:79481404 NA -0.58 -6.55 -0.37 2.92e-10 Gut microbiome composition (summer); CESC cis rs8060686 0.858 rs1109166 chr16:67977382 T/C cg26727032 chr16:67993705 SLC12A4 -0.62 -8.97 -0.48 5.52e-17 HDL cholesterol;Metabolic syndrome; CESC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg19193384 chr17:30244184 NA -0.5 -5.87 -0.34 1.29e-8 Hip circumference adjusted for BMI; CESC cis rs1050631 0.960 rs1789516 chr18:33691688 T/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.44 5.7 0.33 3.22e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs3741798 1.000 rs55865572 chr12:12497333 T/C cg08615371 chr12:12503544 MANSC1 0.79 5.65 0.33 4.22e-8 Cerebrospinal fluid biomarker levels; CESC cis rs9467711 0.606 rs9379857 chr6:26367654 G/C cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg11752832 chr7:134001865 SLC35B4 0.51 6.55 0.37 3.04e-10 Mean platelet volume; CESC cis rs7904368 0.951 rs7074647 chr10:16855455 T/C cg23933602 chr10:16859644 RSU1 0.79 8.26 0.45 6.99e-15 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs728616 0.614 rs17678338 chr10:82098146 C/T cg05935833 chr10:81318306 SFTPA2 -0.48 -6.05 -0.35 4.99e-9 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs11676348 0.755 rs13410318 chr2:219022910 T/G cg00012203 chr2:219082015 ARPC2 0.57 7.33 0.41 2.75e-12 Ulcerative colitis; CESC cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg18252515 chr7:66147081 NA -1.25 -12.55 -0.61 1.18e-28 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03517506 chr2:97778174 ANKRD36 -0.56 -7.14 -0.4 9.03e-12 Gut microbiome composition (summer); CESC cis rs7937682 0.961 rs11828343 chr11:111491322 A/G cg09085632 chr11:111637200 PPP2R1B 0.91 12.11 0.6 3.68e-27 Primary sclerosing cholangitis; CESC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg08888203 chr3:10149979 C3orf24 0.53 6.52 0.37 3.48e-10 Alzheimer's disease; CESC cis rs17021463 0.673 rs17377118 chr4:95285622 G/A cg11021082 chr4:95130006 SMARCAD1 0.5 6.9 0.39 3.75e-11 Testicular germ cell tumor; CESC cis rs3126085 0.877 rs1552992 chr1:152171625 C/G cg03465714 chr1:152285911 FLG -0.43 -5.28 -0.31 2.72e-7 Atopic dermatitis; CESC cis rs10905065 0.965 rs10737019 chr10:5783733 G/A cg11519256 chr10:5708881 ASB13 0.45 6.04 0.35 5.07e-9 Menopause (age at onset); CESC cis rs1153858 1.000 rs7179743 chr15:45638331 G/C cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs7264396 0.563 rs2425130 chr20:34335059 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.73 -0.55 1.57e-22 Total cholesterol levels; CESC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg24503407 chr1:205819492 PM20D1 0.82 13.21 0.63 5.8e-31 Menarche (age at onset); CESC cis rs7208859 0.673 rs7211776 chr17:29120196 T/G cg04154034 chr17:28927549 LRRC37B2 0.55 5.24 0.31 3.25e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg16545954 chr1:2118288 C1orf86 -0.3 -5.85 -0.34 1.46e-8 Height; CESC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg02951883 chr7:2050386 MAD1L1 -0.53 -7.08 -0.4 1.29e-11 Bipolar disorder and schizophrenia; CESC cis rs4727027 0.933 rs917122 chr7:148848257 T/C cg23583168 chr7:148888333 NA -0.81 -12.66 -0.61 4.98e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs12791968 0.765 rs2279359 chr11:44999605 A/G cg11846598 chr11:44996168 LOC221122 0.46 5.64 0.33 4.25e-8 Inhibitory control; CESC cis rs6460942 1.000 rs62448562 chr7:12398785 T/C cg02935154 chr7:12443704 VWDE -0.58 -5.83 -0.34 1.62e-8 Coronary artery disease; CESC cis rs8067354 0.574 rs1292043 chr17:57934169 A/G cg02344993 chr17:57696989 CLTC 0.57 5.91 0.34 1.03e-8 Hemoglobin concentration; CESC cis rs1707322 0.686 rs1084086 chr1:46041100 A/C cg06784218 chr1:46089804 CCDC17 -0.41 -7.23 -0.41 5.17e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.64 -0.33 4.41e-8 Menopause (age at onset); CESC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg18904891 chr8:8559673 CLDN23 0.7 8.26 0.45 7.1e-15 Obesity-related traits; CESC cis rs7927592 0.913 rs12285993 chr11:68302538 A/G cg20283391 chr11:68216788 NA -0.62 -7.44 -0.42 1.42e-12 Total body bone mineral density; CESC cis rs12530845 0.673 rs73721607 chr7:135335822 C/T cg23117316 chr7:135346802 PL-5283 -0.55 -6.16 -0.35 2.7e-9 Red blood cell traits; CESC cis rs78707713 0.512 rs35793747 chr10:71182165 A/G cg12610070 chr10:71211762 TSPAN15 -0.37 -7.75 -0.43 1.98e-13 Venous thromboembolism; CESC cis rs853679 0.607 rs13197574 chr6:28060239 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.83 5.09 0.3 6.76e-7 Depression; CESC cis rs677665 0.537 rs72641832 chr1:9336116 C/A cg25755851 chr1:9335794 NA 0.97 14.24 0.66 1.49e-34 Eosinophil percentage of white cells; CESC cis rs36051895 0.587 rs7035915 chr9:5238253 C/T cg02405213 chr9:5042618 JAK2 -0.56 -6.81 -0.39 6.66e-11 Pediatric autoimmune diseases; CESC cis rs7818345 1.000 rs7833166 chr8:19294634 C/T cg11303988 chr8:19266685 CSGALNACT1 0.35 6.31 0.36 1.14e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs2668423 0.922 rs3826942 chr19:1360575 A/G cg02639931 chr19:1387894 NDUFS7 0.46 7.04 0.4 1.64e-11 Nonalcoholic fatty liver disease; CESC cis rs9300255 0.537 rs1790101 chr12:123704844 T/C cg05973401 chr12:123451056 ABCB9 0.5 5.68 0.33 3.48e-8 Neutrophil percentage of white cells; CESC cis rs4268898 0.662 rs2891382 chr2:24511491 C/G cg06627628 chr2:24431161 ITSN2 -0.96 -11.13 -0.56 7.18e-24 Asthma; CESC trans rs7819412 0.521 rs2409720 chr8:11037903 A/C cg06636001 chr8:8085503 FLJ10661 -0.55 -6.53 -0.37 3.25e-10 Triglycerides; CESC cis rs7481584 0.626 rs2071103 chr11:3040087 C/T cg08508325 chr11:3079039 CARS 0.29 5.03 0.3 8.92e-7 Calcium levels; CESC cis rs35146811 0.771 rs6465762 chr7:99620554 G/A cg22906224 chr7:99728672 NA 0.49 5.77 0.33 2.23e-8 Coronary artery disease; CESC cis rs7223966 1.000 rs7216798 chr17:61740963 G/A cg11494091 chr17:61959527 GH2 0.38 5.35 0.31 1.93e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6460942 0.915 rs17444141 chr7:12460971 T/G cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC cis rs7044106 0.762 rs3903886 chr9:123383646 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.77 -12.08 -0.6 4.56e-27 Hip circumference adjusted for BMI; CESC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs9300255 0.568 rs1627724 chr12:123638580 T/A cg19016782 chr12:123741754 C12orf65 -0.4 -5.74 -0.33 2.64e-8 Neutrophil percentage of white cells; CESC cis rs854765 0.583 rs8065970 chr17:17858771 A/G cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC cis rs7267979 1.000 rs11100 chr20:25281184 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs10791323 0.628 rs10750543 chr11:133718467 G/A cg15485101 chr11:133734466 NA 0.36 5.89 0.34 1.17e-8 Childhood ear infection; CESC cis rs8014204 1.000 rs8014204 chr14:75322794 A/G cg11812906 chr14:75593930 NEK9 0.44 5.48 0.32 1.01e-7 Caffeine consumption; CESC cis rs7845219 0.544 rs9643352 chr8:95918288 C/T cg09323728 chr8:95962352 TP53INP1 -0.32 -6.23 -0.36 1.8e-9 Type 2 diabetes; CESC cis rs2191566 0.691 rs8104605 chr19:44589016 C/T cg20607764 chr19:44506953 ZNF230 0.45 5.6 0.33 5.31e-8 Acute lymphoblastic leukemia (childhood); CESC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg01341218 chr17:43662625 NA -0.52 -6.78 -0.38 7.67e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6901004 0.772 rs191632 chr6:111544882 C/T cg15721981 chr6:111408429 SLC16A10 -0.36 -5.18 -0.3 4.3e-7 Blood metabolite levels; CESC cis rs11711311 1.000 rs9863050 chr3:113508888 C/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.69 9.48 0.5 1.48e-18 IgG glycosylation; CESC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.62 6.63 0.38 1.93e-10 Gut microbiome composition (summer); CESC cis rs6840258 0.825 rs72667751 chr4:87936379 C/T cg08197287 chr4:87952173 AFF1 -0.4 -5.4 -0.31 1.48e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs7818688 1.000 rs6985880 chr8:96027599 A/G cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs459571 0.959 rs416390 chr9:136908549 C/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.66 8.78 0.47 2.08e-16 Platelet distribution width; CESC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg04369109 chr6:150039330 LATS1 -0.39 -5.43 -0.32 1.28e-7 Lung cancer; CESC cis rs1707322 1.000 rs11211244 chr1:46456673 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17125944 0.686 rs77650471 chr14:53364307 C/T cg00686598 chr14:53173677 PSMC6 0.96 7.21 0.41 5.77e-12 Alzheimer's disease (late onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13762774 chr10:32048991 NA -0.46 -6.81 -0.39 6.37e-11 Gambling; CESC cis rs55728055 0.661 rs62237798 chr22:31976839 G/T cg01338084 chr22:32026380 PISD 1.22 8.02 0.44 3.48e-14 Age-related hearing impairment; CESC cis rs9916302 0.904 rs10221223 chr17:37489100 T/G cg15445000 chr17:37608096 MED1 -0.42 -6.67 -0.38 1.49e-10 Glomerular filtration rate (creatinine); CESC cis rs7208859 0.623 rs9899692 chr17:29156939 C/T cg19761014 chr17:28927070 LRRC37B2 0.74 6.03 0.35 5.43e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2299587 0.623 rs7816738 chr8:17768482 A/G cg08627089 chr8:17753878 FGL1 -0.4 -5.44 -0.32 1.19e-7 Economic and political preferences; CESC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg19774624 chr17:42201019 HDAC5 0.9 15.0 0.68 3.16e-37 Total body bone mineral density; CESC cis rs7116495 0.609 rs2503 chr11:71719403 C/T cg07596299 chr11:71824057 C11orf51 0.74 5.16 0.3 4.92e-7 Severe influenza A (H1N1) infection; CESC cis rs6500395 1.000 rs6500397 chr16:48642235 T/C cg04672837 chr16:48644449 N4BP1 0.51 6.21 0.36 2.03e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs10465746 0.901 rs17475760 chr1:84398435 A/T cg10977910 chr1:84465055 TTLL7 0.47 6.39 0.37 7.37e-10 Obesity-related traits; CESC trans rs17685 0.753 rs1637045 chr7:75703895 T/C cg19862616 chr7:65841803 NCRNA00174 0.87 12.74 0.62 2.5e-29 Coffee consumption;Coffee consumption (cups per day); CESC trans rs7427021 0.967 rs11709545 chr3:163737754 A/C cg07975705 chr5:114961891 TMED7-TICAM2;TMED7 -0.42 -6.14 -0.35 3.03e-9 Bipolar disorder; CESC trans rs11098499 0.691 rs12502524 chr4:120271414 G/A cg25214090 chr10:38739885 LOC399744 0.6 8.3 0.45 5.33e-15 Corneal astigmatism; CESC trans rs72996113 0.702 rs78901113 chr11:100568439 G/A cg01999051 chr6:166797738 BRP44L 0.7 6.08 0.35 4.17e-9 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs2549003 1.000 rs6873426 chr5:131818631 G/T cg21138405 chr5:131827807 IRF1 0.54 9.25 0.49 8e-18 Asthma (sex interaction); CESC cis rs6964587 0.655 rs6965864 chr7:91595596 A/G cg17063962 chr7:91808500 NA 0.46 6.49 0.37 4.29e-10 Breast cancer; CESC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg11644478 chr21:40555479 PSMG1 0.83 12.83 0.62 1.29e-29 Cognitive function; CESC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg25072359 chr17:41440525 NA 0.43 5.83 0.34 1.61e-8 Menopause (age at onset); CESC cis rs72781680 0.898 rs112985192 chr2:24102797 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.72 0.33 2.93e-8 Lymphocyte counts; CESC cis rs1832871 0.672 rs12529235 chr6:158766950 A/G cg07165851 chr6:158734300 TULP4 0.58 6.19 0.36 2.31e-9 Height; CESC cis rs2075371 0.966 rs2544225 chr7:133995838 A/C cg20476274 chr7:133979776 SLC35B4 0.67 9.82 0.52 1.26e-19 Mean platelet volume; CESC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.2e-8 Major depressive disorder; CESC cis rs34286592 0.929 rs9939514 chr16:29855731 G/A cg27338089 chr16:29820515 MAZ 0.48 5.04 0.3 8.68e-7 Multiple sclerosis; CESC cis rs1577917 0.740 rs2842604 chr6:86336300 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -6.94 -0.39 2.99e-11 Response to antipsychotic treatment; CESC cis rs2370759 1.000 rs79578760 chr10:32611264 C/A cg01819863 chr10:32635814 EPC1 1.16 12.51 0.61 1.58e-28 Sexual dysfunction (female); CESC cis rs1707322 1.000 rs4539075 chr1:46358010 C/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.3 0.36 1.22e-9 Bipolar disorder; CESC cis rs9486715 1.000 rs9373985 chr6:97063522 C/G cg18709589 chr6:96969512 KIAA0776 -0.46 -6.39 -0.37 7.34e-10 Headache; CESC cis rs6674176 0.660 rs12726706 chr1:44399942 G/A cg12908607 chr1:44402522 ARTN -0.49 -7.35 -0.41 2.39e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9916302 0.904 rs6503503 chr17:37514373 G/A cg07936489 chr17:37558343 FBXL20 0.78 10.7 0.55 1.93e-22 Glomerular filtration rate (creatinine); CESC cis rs861020 0.677 rs2049998 chr1:210031154 C/T cg05527609 chr1:210001259 C1orf107 -1.02 -12.03 -0.59 6.72e-27 Orofacial clefts; CESC cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg02297831 chr4:17616191 MED28 0.54 6.26 0.36 1.5e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7918232 0.943 rs4747584 chr10:27373333 G/A cg14442939 chr10:27389572 ANKRD26 0.7 6.5 0.37 4.04e-10 Breast cancer; CESC cis rs13294100 0.929 rs10435770 chr9:17581168 C/G cg11213383 chr9:17579734 SH3GL2 -0.36 -5.58 -0.32 5.98e-8 Parkinson's disease; CESC cis rs1153858 1.000 rs4627277 chr15:45652768 C/A cg21132104 chr15:45694354 SPATA5L1 0.85 11.64 0.58 1.47e-25 Homoarginine levels; CESC trans rs7937682 0.889 rs493865 chr11:111495178 A/C cg18187862 chr3:45730750 SACM1L 0.47 5.99 0.35 6.68e-9 Primary sclerosing cholangitis; CESC cis rs9583531 0.600 rs6492305 chr13:111361400 C/T cg15841412 chr13:111365552 ING1 0.52 6.74 0.38 1.01e-10 Coronary artery disease; CESC cis rs11030122 0.702 rs17279635 chr11:3973083 A/C cg18678763 chr11:4115507 RRM1 0.48 6.48 0.37 4.42e-10 Mean platelet volume;Platelet distribution width; CESC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg11843238 chr5:131593191 PDLIM4 0.38 5.6 0.33 5.25e-8 Acylcarnitine levels; CESC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg24549020 chr5:56110836 MAP3K1 0.41 5.13 0.3 5.53e-7 Coronary artery disease; CESC cis rs7264396 0.528 rs7273880 chr20:34551507 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.2 0.36 2.18e-9 Total cholesterol levels; CESC cis rs12142240 0.698 rs41294478 chr1:46818442 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs11252926 0.966 rs61831030 chr10:578869 C/T cg16386425 chr10:429943 DIP2C 0.47 5.04 0.3 8.44e-7 Psychosis in Alzheimer's disease; CESC cis rs1348850 1.000 rs3927978 chr2:178443854 A/G cg22681709 chr2:178499509 PDE11A 0.36 5.6 0.33 5.35e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12730826 chr1:205179972 DSTYK 0.55 6.04 0.35 5.26e-9 Gut microbiome composition (summer); CESC cis rs9467711 0.606 rs9379858 chr6:26367689 T/C cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9914988 0.832 rs12946132 chr17:27157362 T/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs7659604 0.540 rs4833775 chr4:122716826 T/C cg19748678 chr4:122722346 EXOSC9 -0.43 -5.3 -0.31 2.47e-7 Type 2 diabetes; CESC cis rs7772486 0.902 rs1331643 chr6:146398873 T/A cg05347473 chr6:146136440 FBXO30 0.47 6.54 0.37 3.1e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs5757676 1.000 rs5757676 chr22:39841700 T/C cg24399712 chr22:39784796 NA -0.81 -8.7 -0.47 3.49e-16 IgG glycosylation; CESC trans rs61931739 0.500 rs7955247 chr12:34126580 G/A cg26384229 chr12:38710491 ALG10B 0.6 8.43 0.46 2.28e-15 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs7659006 chr4:98934529 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg04317338 chr11:64019027 PLCB3 0.82 8.4 0.46 2.83e-15 Mean platelet volume; CESC cis rs870825 0.860 rs72703521 chr4:185603080 T/C cg04058563 chr4:185651563 MLF1IP 0.54 5.24 0.31 3.27e-7 Blood protein levels; CESC cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs4950322 0.542 rs56080828 chr1:146655026 G/A cg04954894 chr8:38089920 DDHD2 -0.62 -6.39 -0.37 7.45e-10 Protein quantitative trait loci; CESC cis rs1801251 1.000 rs36007169 chr2:233621834 A/G cg08000102 chr2:233561755 GIGYF2 0.67 9.48 0.5 1.53e-18 Coronary artery disease; CESC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg19163074 chr7:65112434 INTS4L2 -0.46 -5.05 -0.3 8.07e-7 Aortic root size; CESC cis rs6977955 0.838 rs917115 chr7:28172586 T/C cg23620719 chr7:28220237 JAZF1 0.53 5.99 0.35 6.92e-9 Allergic disease (asthma, hay fever or eczema); CESC trans rs208520 0.690 rs12202805 chr6:66703903 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -12.44 -0.61 2.68e-28 Exhaled nitric oxide output; CESC cis rs858239 0.601 rs73272048 chr7:23152653 C/G cg23682824 chr7:23144976 KLHL7 0.55 7.73 0.43 2.24e-13 Cerebrospinal fluid biomarker levels; CESC cis rs11864453 0.713 rs9925763 chr16:72142595 C/A cg01557791 chr16:72042693 DHODH -0.48 -6.32 -0.36 1.08e-9 Fibrinogen levels; CESC cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg05585544 chr11:47624801 NA -0.51 -7.28 -0.41 3.77e-12 Subjective well-being; CESC cis rs1144333 0.737 rs1144339 chr1:76280543 A/G cg10523679 chr1:76189770 ACADM -0.57 -5.44 -0.32 1.22e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg05890377 chr2:74357713 NA 0.77 10.42 0.54 1.51e-21 Gestational age at birth (maternal effect); CESC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg00684032 chr4:1343700 KIAA1530 0.56 8.52 0.46 1.19e-15 Obesity-related traits; CESC cis rs910316 0.763 rs175047 chr14:75479039 C/G cg08847533 chr14:75593920 NEK9 -0.9 -15.92 -0.7 1.65e-40 Height; CESC cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.15e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 0.867 rs4793941 chr17:56472366 G/A cg25039879 chr17:56429692 SUPT4H1 -0.39 -5.1 -0.3 6.37e-7 Intelligence (multi-trait analysis); CESC cis rs910316 0.699 rs175039 chr14:75468950 G/C cg16144293 chr14:75469539 EIF2B2 0.43 5.67 0.33 3.79e-8 Height; CESC trans rs116095464 0.558 rs10052012 chr5:231908 T/C cg00938859 chr5:1591904 SDHAP3 0.63 6.87 0.39 4.49e-11 Breast cancer; CESC cis rs9649465 0.561 rs2429618 chr7:123421662 G/A cg03229431 chr7:123269106 ASB15 0.4 5.59 0.32 5.75e-8 Migraine; CESC cis rs2841277 0.676 rs10438246 chr14:105410183 T/C cg14403583 chr14:105418241 AHNAK2 -0.58 -8.06 -0.44 2.55e-14 Rheumatoid arthritis; CESC cis rs4908768 0.501 rs1024197 chr1:8537058 C/G cg00120948 chr1:8484417 RERE -0.34 -5.23 -0.31 3.51e-7 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CESC trans rs11098499 0.754 rs34425882 chr4:120253177 G/A cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC trans rs10242455 0.702 rs73397481 chr7:99030108 C/T cg09045935 chr12:6379348 NA 0.9 6.02 0.35 5.93e-9 Blood metabolite levels; CESC cis rs9926296 0.607 rs11076629 chr16:89875259 T/C cg27121462 chr16:89883253 FANCA 0.57 7.08 0.4 1.28e-11 Vitiligo; CESC cis rs2963155 0.518 rs853178 chr5:142634799 C/T cg17617527 chr5:142782415 NR3C1 0.84 7.69 0.43 2.95e-13 Breast cancer; CESC cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg22834771 chr12:69754056 YEATS4 -0.48 -6.46 -0.37 4.87e-10 Blood protein levels; CESC cis rs9354308 0.899 rs2814094 chr6:66536275 G/T cg07460842 chr6:66804631 NA -0.56 -6.45 -0.37 5.17e-10 Metabolite levels; CESC cis rs11098499 0.566 rs7664440 chr4:120578540 A/G cg09307838 chr4:120376055 NA 0.75 9.42 0.5 2.26e-18 Corneal astigmatism; CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg18538332 chr22:24372958 LOC391322 -0.78 -11.44 -0.58 6.57e-25 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs798554 0.610 rs1182173 chr7:2878016 C/G cg13628971 chr7:2884303 GNA12 0.38 5.11 0.3 6.26e-7 Height; CESC trans rs9388451 0.626 rs3799708 chr6:126078530 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.66 -9.21 -0.49 1e-17 Brugada syndrome; CESC cis rs12464559 0.579 rs2293221 chr2:152653380 C/T cg01189475 chr2:152685088 ARL5A 0.66 5.81 0.34 1.74e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg07701084 chr6:150067640 NUP43 0.44 5.92 0.34 9.71e-9 Lung cancer; CESC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg10150615 chr22:24372951 LOC391322 -0.59 -8.05 -0.44 2.87e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3793683 0.928 rs10781585 chr10:134553369 C/A cg18305652 chr10:134549665 INPP5A -0.34 -5.41 -0.32 1.4e-7 Migraine; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13777502 chr17:66031814 KPNA2 -0.46 -6.76 -0.38 9.02e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9467773 0.549 rs9461273 chr6:26584526 A/G cg26531700 chr6:26746687 NA 0.35 5.36 0.31 1.78e-7 Intelligence (multi-trait analysis); CESC cis rs9325144 0.647 rs4616077 chr12:39092364 T/C cg26384229 chr12:38710491 ALG10B -0.5 -6.9 -0.39 3.79e-11 Morning vs. evening chronotype; CESC cis rs7267979 0.966 rs2263204 chr20:25377688 A/T cg08601574 chr20:25228251 PYGB -0.36 -5.05 -0.3 8.36e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs1577917 0.771 rs9362230 chr6:86305013 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -7.8 -0.43 1.46e-13 Response to antipsychotic treatment; CESC cis rs9486715 0.867 rs4839687 chr6:96951732 C/A cg06623918 chr6:96969491 KIAA0776 0.93 14.38 0.66 4.75e-35 Headache; CESC cis rs7312933 1.000 rs10880230 chr12:42450253 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.41 5.36 0.31 1.81e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs2806561 0.765 rs4333826 chr1:23517514 C/T cg12483005 chr1:23474871 LUZP1 0.38 6.0 0.35 6.44e-9 Height; CESC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg24578937 chr1:2090814 PRKCZ 0.36 6.49 0.37 4.11e-10 Height; CESC cis rs914615 0.552 rs4971089 chr1:155142927 A/G cg02153340 chr1:155202674 NA -0.37 -5.39 -0.31 1.54e-7 Urinary albumin-to-creatinine ratio; CESC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg03709012 chr19:19516395 GATAD2A 1.01 15.71 0.69 9.73e-40 Tonsillectomy; CESC cis rs73206853 0.764 rs970228 chr12:111070169 G/C cg12870014 chr12:110450643 ANKRD13A 0.64 5.49 0.32 9.25e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14337668 chr9:99883682 NA -0.47 -6.42 -0.37 6.09e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11098499 0.564 rs11098507 chr4:120288286 G/A cg24375607 chr4:120327624 NA 0.42 5.2 0.3 3.94e-7 Corneal astigmatism; CESC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.89 0.62 7.89e-30 Alzheimer's disease; CESC cis rs10779751 1.000 rs718206 chr1:11294474 T/A cg08854313 chr1:11322531 MTOR 0.79 10.7 0.55 1.85e-22 Body mass index; CESC cis rs1801251 1.000 rs4973054 chr2:233710713 G/C cg08000102 chr2:233561755 GIGYF2 -0.69 -9.93 -0.52 5.72e-20 Coronary artery disease; CESC cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg14784868 chr12:69753453 YEATS4 0.84 13.42 0.64 1.11e-31 Blood protein levels; CESC cis rs897080 0.515 rs1067346 chr2:44618811 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 5.94 0.34 8.71e-9 Height; CESC cis rs11098499 0.588 rs2389874 chr4:120554991 A/G cg09307838 chr4:120376055 NA -0.66 -8.66 -0.47 4.83e-16 Corneal astigmatism; CESC cis rs477692 0.544 rs7904404 chr10:131447612 G/A cg24747557 chr10:131355152 MGMT 0.46 6.19 0.36 2.33e-9 Response to temozolomide; CESC cis rs12617721 0.574 rs6542754 chr2:99025400 C/T cg10123293 chr2:99228465 UNC50 0.4 5.37 0.31 1.76e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7833986 0.534 rs72653928 chr8:56907735 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.23 0.41 5.33e-12 Height; CESC cis rs62229266 0.563 rs6517325 chr21:37434978 T/C cg08632701 chr21:37451849 NA -0.4 -5.49 -0.32 9.62e-8 Mitral valve prolapse; CESC cis rs9611565 0.559 rs739136 chr22:42100275 C/T cg06481639 chr22:41940642 POLR3H -0.59 -5.91 -0.34 1.05e-8 Vitiligo; CESC cis rs6500602 0.702 rs11645519 chr16:4538989 G/A cg08645402 chr16:4508243 NA 0.57 9.27 0.49 6.82e-18 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17961057 chr2:74645699 C2orf81 -0.61 -7.26 -0.41 4.34e-12 Gut microbiome composition (summer); CESC cis rs694739 0.930 rs574087 chr11:64102948 A/G cg02228329 chr11:64053129 BAD;GPR137 0.71 9.08 0.49 2.64e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg24675658 chr1:53192096 ZYG11B -0.52 -6.56 -0.37 2.89e-10 Monocyte count; CESC cis rs8060686 0.565 rs55857142 chr16:68236741 A/T cg26727032 chr16:67993705 SLC12A4 -0.52 -5.73 -0.33 2.72e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs962856 0.964 rs600388 chr2:67656809 A/G cg09028215 chr2:67624308 ETAA1 -0.39 -5.23 -0.31 3.39e-7 Pancreatic cancer; CESC cis rs6032067 0.641 rs34638860 chr20:43765839 C/T cg10761708 chr20:43804764 PI3 0.54 6.07 0.35 4.4e-9 Blood protein levels; CESC cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.64e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs4835473 0.864 rs13101482 chr4:144910616 G/A cg25736465 chr4:144833511 NA 0.42 6.43 0.37 6.02e-10 Immature fraction of reticulocytes; CESC cis rs28374715 0.528 rs7178360 chr15:41631175 T/A cg20272979 chr15:41787780 ITPKA 0.46 5.44 0.32 1.19e-7 Ulcerative colitis; CESC cis rs2635047 0.638 rs2571008 chr18:44649950 T/C cg19077165 chr18:44547161 KATNAL2 -0.37 -5.04 -0.3 8.63e-7 Educational attainment; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08732623 chr10:127408269 C10orf137 -0.45 -6.21 -0.36 2.03e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4243830 1.000 rs11809957 chr1:6584420 C/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.69 5.84 0.34 1.5e-8 Body mass index; CESC cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg19052272 chr2:3704530 ALLC -0.48 -5.92 -0.34 1.01e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs73206853 0.640 rs871921 chr12:111115113 G/C cg12870014 chr12:110450643 ANKRD13A 0.76 7.62 0.42 4.46e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs10791097 0.694 rs2236717 chr11:130739887 G/T cg12179176 chr11:130786555 SNX19 0.64 10.04 0.52 2.69e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11098499 0.909 rs28884220 chr4:120307211 A/G cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs10911251 0.546 rs2027085 chr1:183108611 G/T ch.1.3577855R chr1:183094577 LAMC1 -0.82 -12.85 -0.62 1.04e-29 Colorectal cancer; CESC cis rs6577655 0.517 rs62525562 chr8:135587076 C/T cg17885191 chr8:135476712 NA 0.45 5.1 0.3 6.63e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs5758659 0.652 rs133301 chr22:42390093 C/T cg15557168 chr22:42548783 NA -0.43 -6.29 -0.36 1.27e-9 Cognitive function; CESC cis rs7178572 0.568 rs1191196 chr15:77646504 C/T cg22256960 chr15:77711686 NA 0.54 6.65 0.38 1.67e-10 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10807698 chr14:103243805 TRAF3 0.66 7.69 0.43 2.91e-13 Gut microbiome composition (summer); CESC cis rs7851660 0.967 rs1443434 chr9:100617479 G/T cg13688889 chr9:100608707 NA -0.69 -10.57 -0.54 4.92e-22 Strep throat; CESC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.5 0.37 3.98e-10 Prudent dietary pattern; CESC cis rs6138458 1.000 rs11906373 chr20:24938832 A/G cg06937882 chr20:24974362 C20orf3 -0.35 -5.05 -0.3 8.34e-7 Blood protein levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05330668 chr14:24836090 NFATC4 -0.47 -6.55 -0.37 2.99e-10 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg05340658 chr4:99064831 C4orf37 0.82 12.87 0.62 9.16e-30 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19877921 chr17:61904685 PSMC5;FTSJ3 0.53 6.12 0.35 3.29e-9 Gut microbiome composition (summer); CESC cis rs258892 0.895 rs36040109 chr5:72050659 A/G cg21869765 chr5:72125136 TNPO1 -0.41 -5.3 -0.31 2.49e-7 Small cell lung carcinoma; CESC cis rs9532580 0.710 rs9577090 chr13:41225228 G/T cg21288729 chr13:41239152 FOXO1 0.65 8.35 0.46 3.76e-15 Mean corpuscular hemoglobin; CESC cis rs12765878 1.000 rs4918067 chr10:105644636 A/C cg11005552 chr10:105648138 OBFC1 0.36 5.29 0.31 2.51e-7 Coronary artery disease; CESC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg11890956 chr21:40555474 PSMG1 1.17 21.95 0.8 1.41e-61 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01029985 chr19:40932112 SERTAD1 -0.55 -6.26 -0.36 1.5e-9 Gut microbiome composition (summer); CESC cis rs2191566 0.576 rs370809 chr19:44493830 C/T cg20607764 chr19:44506953 ZNF230 0.44 5.58 0.32 5.9e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs778371 0.723 rs12619195 chr2:233678326 G/A cg08000102 chr2:233561755 GIGYF2 -0.84 -14.27 -0.66 1.18e-34 Schizophrenia; CESC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg18490616 chr2:88469792 THNSL2 0.55 5.29 0.31 2.59e-7 Plasma clusterin levels; CESC cis rs7666738 0.830 rs1527517 chr4:98931907 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC cis rs34779708 0.931 rs2384289 chr10:35343525 G/A cg03585969 chr10:35415529 CREM 0.78 10.21 0.53 7.36e-21 Inflammatory bowel disease;Crohn's disease; CESC trans rs7937682 1.000 rs10502147 chr11:111569931 G/A cg18187862 chr3:45730750 SACM1L -0.53 -6.07 -0.35 4.52e-9 Primary sclerosing cholangitis; CESC cis rs919433 0.854 rs787994 chr2:198223121 T/C cg20885578 chr2:198174922 NA 0.4 5.37 0.31 1.73e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7000551 0.715 rs12544074 chr8:22338378 A/G cg12081754 chr8:22256438 SLC39A14 0.45 6.09 0.35 3.97e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs3771570 1.000 rs1056801 chr2:242292307 T/C cg21155796 chr2:242212141 HDLBP 0.6 5.18 0.3 4.5e-7 Prostate cancer; CESC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg02807482 chr3:125708958 NA -0.4 -5.17 -0.3 4.73e-7 Blood pressure (smoking interaction); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04524006 chr5:111093197 C5orf13 -0.5 -6.39 -0.37 7.28e-10 Asthma; CESC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg20887711 chr4:1340912 KIAA1530 0.85 11.41 0.57 8.51e-25 Longevity; CESC cis rs12618769 0.597 rs1847550 chr2:99052299 C/T cg10123293 chr2:99228465 UNC50 0.41 5.42 0.32 1.31e-7 Bipolar disorder; CESC cis rs17253792 0.822 rs10145687 chr14:56124384 T/C cg01858014 chr14:56050164 KTN1 -0.71 -6.19 -0.36 2.22e-9 Putamen volume; CESC cis rs7829975 0.514 rs2920991 chr8:8259117 T/A cg15556689 chr8:8085844 FLJ10661 0.59 7.85 0.43 1.06e-13 Mood instability; CESC cis rs7589342 0.628 rs12996286 chr2:106399667 A/G cg16077055 chr2:106428750 NCK2 0.51 6.18 0.36 2.34e-9 Addiction; CESC cis rs6426558 0.537 rs2718193 chr1:227404672 C/G cg10327440 chr1:227177885 CDC42BPA 0.45 5.53 0.32 7.58e-8 Neutrophil percentage of white cells; CESC cis rs6087990 0.899 rs4911107 chr20:31374991 G/A cg13636640 chr20:31349939 DNMT3B 0.89 15.31 0.69 2.42e-38 Ulcerative colitis; CESC cis rs763121 0.853 rs5757213 chr22:39053888 C/T cg06022373 chr22:39101656 GTPBP1 0.88 13.91 0.65 2.06e-33 Menopause (age at onset); CESC cis rs9308433 0.529 rs59864830 chr1:214474889 A/G cg06198575 chr1:214491504 SMYD2 0.46 5.25 0.31 3.08e-7 IgG glycosylation; CESC cis rs11098499 0.863 rs10034450 chr4:120455649 A/G cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.24e-28 Corneal astigmatism; CESC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg17372223 chr3:52568218 NT5DC2 0.42 6.19 0.36 2.24e-9 Bipolar disorder; CESC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg19163074 chr7:65112434 INTS4L2 -0.41 -5.11 -0.3 6.29e-7 Aortic root size; CESC cis rs9488822 0.636 rs10872142 chr6:116369052 C/A cg05304507 chr6:116381966 FRK 0.26 6.75 0.38 9.45e-11 Cholesterol, total;LDL cholesterol; CESC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs11583043 0.918 rs6693456 chr1:101424561 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 5.51 0.32 8.62e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg09699651 chr6:150184138 LRP11 0.4 5.15 0.3 4.99e-7 Lung cancer; CESC cis rs561341 1.000 rs484175 chr17:30309041 G/A cg00745463 chr17:30367425 LRRC37B -0.78 -7.09 -0.4 1.2e-11 Hip circumference adjusted for BMI; CESC cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg26597838 chr10:835615 NA 0.87 9.15 0.49 1.55e-17 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01861349 chr15:75198956 C15orf17 0.54 6.22 0.36 1.94e-9 Gut microbiome composition (summer); CESC cis rs4319547 0.661 rs10846830 chr12:122897220 C/G cg05707623 chr12:122985044 ZCCHC8 -0.53 -6.11 -0.35 3.47e-9 Body mass index; CESC cis rs7336332 0.598 rs75439483 chr13:28010512 A/G cg01674679 chr13:27998804 GTF3A -0.58 -5.34 -0.31 2.04e-7 Weight; CESC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg18099408 chr3:52552593 STAB1 -0.31 -5.23 -0.31 3.4e-7 Electroencephalogram traits; CESC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.62 0.38 1.94e-10 Prudent dietary pattern; CESC cis rs7666738 0.830 rs10031751 chr4:98939134 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9399135 0.869 rs9402675 chr6:135325794 C/G cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs9788682 0.747 rs938682 chr15:78896547 A/G cg24631222 chr15:78858424 CHRNA5 0.78 9.77 0.51 1.92e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs9611565 0.918 rs9611562 chr22:41760172 T/G cg06481639 chr22:41940642 POLR3H -0.7 -7.37 -0.41 2.23e-12 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13822231 chr9:133588088 ABL1 -0.47 -6.17 -0.35 2.53e-9 Fibrinogen levels; CESC cis rs34330 0.562 rs7486387 chr12:12866911 G/A cg09462578 chr12:12878428 APOLD1 -0.7 -7.61 -0.42 4.78e-13 Systemic lupus erythematosus; CESC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg27170947 chr2:26402098 FAM59B -0.72 -8.31 -0.45 5.18e-15 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs17746033 chr14:56061837 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg06108461 chr20:60628389 TAF4 -0.59 -7.99 -0.44 4.06e-14 Body mass index; CESC trans rs4756846 1.000 rs17554911 chr11:16432694 A/G cg05579622 chr5:10618622 ANKRD33B 0.76 6.91 0.39 3.7e-11 Obesity and osteoporosis; CESC cis rs8141529 0.748 rs1318026 chr22:29283518 A/G cg02153584 chr22:29168773 CCDC117 0.6 7.84 0.43 1.13e-13 Lymphocyte counts; CESC cis rs6062302 0.522 rs914558 chr20:62216976 A/G cg09650180 chr20:62225654 GMEB2 -0.8 -8.92 -0.48 7.9e-17 Glioblastoma; CESC cis rs826838 0.510 rs10506129 chr12:39224242 A/T cg26384229 chr12:38710491 ALG10B 0.7 10.51 0.54 7.69e-22 Heart rate; CESC cis rs7953249 0.807 rs2393775 chr12:121424574 G/A cg02403541 chr12:121454288 C12orf43 -0.51 -6.84 -0.39 5.58e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg15445000 chr17:37608096 MED1 -0.41 -6.8 -0.39 6.8e-11 Glomerular filtration rate (creatinine); CESC cis rs919433 0.783 rs788014 chr2:198228997 G/A cg20885578 chr2:198174922 NA 0.4 5.2 0.3 4.09e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg24879335 chr3:133465180 TF 0.36 6.37 0.36 8.47e-10 Iron status biomarkers; CESC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs1545843 0.568 rs11116351 chr12:84775744 T/C cg03015433 chr16:56623111 MT3 -0.33 -6.05 -0.35 4.9e-9 Major depressive disorder; CESC cis rs7592578 0.599 rs62180992 chr2:191285732 A/G cg10560079 chr2:191398806 TMEM194B -0.6 -5.73 -0.33 2.73e-8 Diastolic blood pressure; CESC cis rs858239 0.536 rs6956974 chr7:23252318 C/G cg23682824 chr7:23144976 KLHL7 -0.43 -5.64 -0.33 4.28e-8 Cerebrospinal fluid biomarker levels; CESC cis rs5769707 0.632 rs135876 chr22:50013573 A/G cg20744362 chr22:50050164 C22orf34 0.36 5.05 0.3 8.22e-7 Monocyte count;Monocyte percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10387901 chr3:15106641 MRPS25 -0.45 -6.55 -0.37 2.97e-10 Gambling; CESC cis rs28489187 0.597 rs233053 chr1:85839507 G/A cg16011679 chr1:85725395 C1orf52 0.44 5.3 0.31 2.44e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs9303401 0.659 rs12944971 chr17:56988801 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.96 10.69 0.55 2.11e-22 Cognitive test performance; CESC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg17949981 chr6:28129498 ZNF389 0.42 5.24 0.31 3.27e-7 Depression; CESC cis rs941873 0.772 rs7086293 chr10:81103247 T/C cg11057378 chr10:81107060 PPIF 0.36 5.89 0.34 1.18e-8 Height; CESC cis rs11650494 0.908 rs9907478 chr17:47395729 C/T cg08112188 chr17:47440006 ZNF652 1.29 8.63 0.47 5.85e-16 Prostate cancer; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg20284698 chr3:48956327 C3orf71;ARIH2 0.44 6.02 0.35 5.91e-9 Breast cancer;Type 2 diabetes; CESC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg07090678 chr1:91966139 CDC7 0.38 5.33 0.31 2.08e-7 Breast cancer; CESC cis rs36051895 0.632 rs62541916 chr9:5151904 C/A cg02405213 chr9:5042618 JAK2 -0.53 -6.57 -0.37 2.66e-10 Pediatric autoimmune diseases; CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg25934064 chr3:52569026 NT5DC2 0.27 5.69 0.33 3.39e-8 Electroencephalogram traits; CESC cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10895547 0.565 rs492441 chr11:103792570 C/T cg23613023 chr12:115353932 NA -0.36 -6.03 -0.35 5.53e-9 LDL cholesterol; CESC cis rs7116495 1.000 rs7116495 chr11:71762085 C/T cg10381502 chr11:71823885 C11orf51 -0.66 -5.35 -0.31 1.89e-7 Severe influenza A (H1N1) infection; CESC cis rs2841277 0.509 rs11850949 chr14:105408827 A/C cg19901468 chr14:105411992 AHNAK2 -0.63 -9.05 -0.49 3.14e-17 Rheumatoid arthritis; CESC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg11764359 chr7:65958608 NA -0.79 -11.16 -0.57 5.72e-24 Aortic root size; CESC cis rs778371 0.958 rs778341 chr2:233728801 C/A cg08000102 chr2:233561755 GIGYF2 -0.81 -11.29 -0.57 2.19e-24 Schizophrenia; CESC cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg10523679 chr1:76189770 ACADM 0.64 6.11 0.35 3.63e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7160336 0.641 rs17782448 chr14:74682701 G/C cg08255017 chr14:74727001 VSX2 -0.38 -5.6 -0.33 5.35e-8 Blood protein levels; CESC cis rs155076 0.711 rs4769158 chr13:21881975 T/C cg11317459 chr13:21872234 NA 1.2 15.33 0.69 2.11e-38 White matter hyperintensity burden; CESC trans rs8073060 0.505 rs225276 chr17:33973034 T/C cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs1707322 1.000 rs785469 chr1:46521091 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.65 -0.33 4.08e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs447735 0.565 rs10852626 chr16:89914633 T/G cg03605463 chr16:89740564 NA -0.45 -5.12 -0.3 5.82e-7 Hemoglobin concentration; CESC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs9302635 0.640 rs9933009 chr16:72190650 G/A cg01557791 chr16:72042693 DHODH -0.49 -5.68 -0.33 3.57e-8 Blood protein levels; CESC cis rs11249608 0.548 rs10516150 chr5:178459169 G/C cg01312482 chr5:178451176 ZNF879 -0.45 -6.08 -0.35 4.26e-9 Pubertal anthropometrics; CESC trans rs2472476 0.900 rs2472479 chr9:107525165 G/T cg14553338 chr2:66689807 MEIS1 0.46 6.41 0.37 6.74e-10 Obesity-related traits; CESC cis rs863345 0.604 rs10908666 chr1:158500098 G/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.49e-11 Pneumococcal bacteremia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21951070 chr3:185826924 ETV5 0.59 6.05 0.35 5.02e-9 Gut microbiome composition (summer); CESC trans rs4824093 0.610 rs13340054 chr22:50311726 G/A cg09872104 chr7:134855509 C7orf49 -0.86 -6.13 -0.35 3.09e-9 Amyotrophic lateral sclerosis (sporadic); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg00097228 chr1:63783167 NA 0.51 6.12 0.35 3.41e-9 Psoriatic arthritis; CESC cis rs7818345 1.000 rs7835461 chr8:19307051 C/T cg11303988 chr8:19266685 CSGALNACT1 0.35 6.11 0.35 3.48e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs67072384 0.818 rs1872128 chr11:72465526 C/T cg04827223 chr11:72435913 ARAP1 -0.7 -7.1 -0.4 1.16e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18190547 chr1:249142064 ZNF672 0.51 7.18 0.4 6.87e-12 Fibrinogen levels; CESC cis rs4268898 0.662 rs9917355 chr2:24433400 C/T cg08917208 chr2:24149416 ATAD2B 0.55 5.27 0.31 2.89e-7 Asthma; CESC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg03709012 chr19:19516395 GATAD2A -0.97 -14.38 -0.66 4.86e-35 Tonsillectomy; CESC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg05313129 chr8:58192883 C8orf71 -0.54 -6.21 -0.36 1.99e-9 Developmental language disorder (linguistic errors); CESC cis rs7520050 0.966 rs7515491 chr1:46355079 A/G cg03146154 chr1:46216737 IPP -0.49 -6.43 -0.37 5.9e-10 Red blood cell count;Reticulocyte count; CESC cis rs4849845 0.598 rs3933620 chr2:121034936 A/T cg24070213 chr2:121070622 NA 0.44 6.41 0.37 6.46e-10 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26571942 chr2:30455099 LBH 0.55 6.24 0.36 1.75e-9 Gut microbiome composition (summer); CESC cis rs10504073 0.669 rs12548464 chr8:50023867 C/T cg00325661 chr8:49890786 NA 0.5 7.49 0.42 1.02e-12 Blood metabolite ratios; CESC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg02951883 chr7:2050386 MAD1L1 -0.58 -7.77 -0.43 1.72e-13 Bipolar disorder and schizophrenia; CESC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.34 0.5 3.98e-18 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23039201 chr2:27851887 GPN1;CCDC121 0.65 8.02 0.44 3.39e-14 Gut microbiome composition (summer); CESC cis rs7223966 1.000 rs17549954 chr17:61707032 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.16 0.35 2.7e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg21361702 chr7:150065534 REPIN1 0.54 5.89 0.34 1.18e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg20503657 chr10:835505 NA 0.67 6.06 0.35 4.55e-9 Eosinophil percentage of granulocytes; CESC cis rs6088580 0.634 rs6059878 chr20:33087166 A/T cg08999081 chr20:33150536 PIGU 0.65 11.26 0.57 2.65e-24 Glomerular filtration rate (creatinine); CESC cis rs9486719 1.000 rs12213426 chr6:96896035 T/C cg18709589 chr6:96969512 KIAA0776 -0.54 -5.87 -0.34 1.3e-8 Migraine;Coronary artery disease; CESC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.53 -7.21 -0.4 5.87e-12 Lymphocyte counts; CESC cis rs9297145 0.673 rs62473003 chr7:98725660 A/G cg05967295 chr7:98741636 SMURF1 0.91 8.99 0.48 4.78e-17 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs1448094 0.511 rs17279240 chr12:86162550 A/T cg00310523 chr12:86230176 RASSF9 0.35 5.59 0.32 5.75e-8 Major depressive disorder; CESC cis rs34311866 0.808 rs4583705 chr4:973036 C/T cg07828340 chr4:882639 GAK 0.88 6.92 0.39 3.33e-11 Parkinson's disease; CESC cis rs9768139 1.000 rs9768139 chr7:158120731 G/A cg24154853 chr7:158122151 PTPRN2 -0.38 -5.95 -0.34 8.6e-9 Calcium levels; CESC cis rs12410462 0.901 rs1120000 chr1:227659615 T/C cg04117972 chr1:227635322 NA 0.63 6.27 0.36 1.47e-9 Major depressive disorder; CESC trans rs6089829 0.855 rs6090203 chr20:61663632 G/A cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg18876405 chr7:65276391 NA -0.55 -7.48 -0.42 1.11e-12 Aortic root size; CESC trans rs10463316 0.894 rs13361316 chr5:150765593 T/C cg24389359 chr12:111284228 CCDC63 -0.34 -6.2 -0.36 2.19e-9 Metabolite levels (Pyroglutamine); CESC cis rs9309711 0.621 rs7586472 chr2:3473670 G/A cg10845886 chr2:3471009 TTC15 -0.63 -8.64 -0.47 5.3e-16 Neurofibrillary tangles; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg19536664 chr17:6899085 ALOX12 0.39 8.6 0.47 7.07e-16 Tonsillectomy; CESC cis rs8014204 0.753 rs6574199 chr14:75356103 T/C cg08847533 chr14:75593920 NEK9 -0.44 -5.4 -0.32 1.45e-7 Caffeine consumption; CESC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg10494973 chr17:80897199 TBCD -0.48 -6.04 -0.35 5.14e-9 Breast cancer; CESC cis rs10911232 0.507 rs10797822 chr1:183017769 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.5 0.64 5.78e-32 Hypertriglyceridemia; CESC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg23978390 chr7:1156363 C7orf50 0.47 6.41 0.37 6.75e-10 Longevity;Endometriosis; CESC cis rs9517313 0.551 rs2274051 chr13:99091634 A/G cg07423050 chr13:99094983 FARP1 0.36 6.35 0.36 9.47e-10 Neuroticism; CESC cis rs55882075 0.537 rs62406698 chr5:179110429 C/T cg14593053 chr5:179126677 CANX 0.54 6.91 0.39 3.62e-11 Monocyte percentage of white cells; CESC cis rs7116495 0.609 rs2155145 chr11:71719619 G/T cg10381502 chr11:71823885 C11orf51 -1.16 -7.71 -0.43 2.62e-13 Severe influenza A (H1N1) infection; CESC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg07701084 chr6:150067640 NUP43 0.43 5.81 0.34 1.78e-8 Lung cancer; CESC cis rs1580019 0.587 rs6968990 chr7:32552159 C/T cg06627557 chr7:32535165 LSM5;AVL9 -1.04 -17.38 -0.73 1.12e-45 Cognitive ability; CESC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg19163074 chr7:65112434 INTS4L2 0.46 5.05 0.3 8.07e-7 Aortic root size; CESC cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg05347473 chr6:146136440 FBXO30 -0.54 -7.0 -0.4 2.06e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9905704 0.633 rs2632511 chr17:56490989 G/A cg12560992 chr17:57184187 TRIM37 0.62 5.62 0.33 4.95e-8 Testicular germ cell tumor; CESC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.77 6.63 0.38 1.87e-10 Platelet count; CESC cis rs2301436 0.512 rs6925969 chr6:167501738 C/A cg23791538 chr6:167370224 RNASET2 -0.53 -6.66 -0.38 1.59e-10 Crohn's disease; CESC cis rs10851478 0.802 rs7162741 chr15:49905410 A/G cg08060515 chr15:49448048 GALK2;COPS2 0.43 5.26 0.31 3e-7 Oral cavity cancer; CESC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg27170947 chr2:26402098 FAM59B -0.6 -7.23 -0.41 5.28e-12 Gut microbiome composition (summer); CESC cis rs6740322 0.696 rs10188539 chr2:43484675 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.77 -8.39 -0.46 2.95e-15 Coronary artery disease; CESC cis rs7089973 0.523 rs7093330 chr10:116744574 T/A cg23260525 chr10:116636907 FAM160B1 0.3 5.24 0.31 3.21e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs77972916 0.505 rs6727824 chr2:43528377 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.63 -6.01 -0.35 6.27e-9 Granulocyte percentage of myeloid white cells; CESC cis rs17376456 1.000 rs13174700 chr5:93554644 G/A cg21475434 chr5:93447410 FAM172A 0.88 7.46 0.42 1.25e-12 Diabetic retinopathy; CESC cis rs7520050 0.667 rs11211176 chr1:46223086 C/T cg06784218 chr1:46089804 CCDC17 -0.36 -6.48 -0.37 4.5e-10 Red blood cell count;Reticulocyte count; CESC cis rs796364 0.951 rs2881593 chr2:201000347 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.62 -6.46 -0.37 4.94e-10 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12309172 chr15:91454691 MAN2A2 -0.52 -6.48 -0.37 4.45e-10 Gut microbiome composition (summer); CESC cis rs6460942 0.915 rs75732743 chr7:12454095 C/T cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg04414720 chr1:150670196 GOLPH3L 0.58 7.55 0.42 7.07e-13 Melanoma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24641125 chr21:40721130 HMGN1 -0.46 -6.09 -0.35 3.86e-9 Gut microbiota (bacterial taxa); CESC cis rs8005677 1.000 rs1951119 chr14:23388326 A/C cg01529538 chr14:23388837 RBM23 0.51 6.88 0.39 4.29e-11 Cognitive ability (multi-trait analysis); CESC cis rs7103648 0.695 rs7933019 chr11:47509137 G/C cg10504702 chr11:47789108 FNBP4 0.42 5.2 0.3 4.01e-7 Diastolic blood pressure;Systolic blood pressure; CESC trans rs61931739 0.500 rs34418276 chr12:34535976 C/T cg13010199 chr12:38710504 ALG10B 0.5 6.31 0.36 1.16e-9 Morning vs. evening chronotype; CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg18099408 chr3:52552593 STAB1 -0.35 -6.35 -0.36 9.06e-10 Cognitive function; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08118649 chr12:99038419 APAF1;IKBIP 0.48 6.21 0.36 2.08e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs77956314 0.515 rs10850741 chr12:117432004 A/G cg02017074 chr12:117425053 FBXW8 0.78 8.49 0.46 1.46e-15 Subcortical brain region volumes;Hippocampal volume; CESC cis rs1008375 0.933 rs6449324 chr4:17694880 G/C cg02297831 chr4:17616191 MED28 0.43 5.27 0.31 2.79e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.12 -0.3 5.96e-7 Total body bone mineral density; CESC cis rs8062405 0.755 rs4788076 chr16:28570005 C/T cg01378222 chr16:28622494 SULT1A1 0.31 5.15 0.3 5.01e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs10197940 0.789 rs2444256 chr2:152280365 C/T cg19508488 chr2:152266495 RIF1 0.43 5.19 0.3 4.1e-7 Lung cancer; CESC cis rs7264396 0.635 rs6058382 chr20:34553948 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.18 0.36 2.37e-9 Total cholesterol levels; CESC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg12311346 chr5:56204834 C5orf35 0.65 8.75 0.47 2.51e-16 Initial pursuit acceleration; CESC trans rs17057718 1.000 rs2035656 chr3:57125101 A/C cg04869497 chr17:20059225 CYTSB -0.56 -5.99 -0.35 6.63e-9 Cerebrospinal fluid biomarker levels; CESC cis rs11785400 1.000 rs3735994 chr8:143742683 C/T cg24634471 chr8:143751801 JRK 0.47 6.21 0.36 2e-9 Schizophrenia; CESC trans rs7178375 1.000 rs28881289 chr15:31223955 A/G cg04373760 chr16:53404718 NA 0.54 7.26 0.41 4.39e-12 Hypertriglyceridemia; CESC cis rs6963495 0.818 rs17343556 chr7:105151272 C/T cg19920283 chr7:105172520 RINT1 0.67 6.33 0.36 1.02e-9 Bipolar disorder (body mass index interaction); CESC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg13647721 chr17:30228624 UTP6 -0.62 -5.83 -0.34 1.63e-8 Hip circumference adjusted for BMI; CESC cis rs1784581 0.855 rs1893101 chr6:162384371 G/C cg17173639 chr6:162384350 PARK2 -0.81 -13.3 -0.63 2.97e-31 Itch intensity from mosquito bite; CESC cis rs8062405 0.756 rs151301 chr16:28497059 T/A cg08761264 chr16:28874980 SH2B1 -0.45 -5.26 -0.31 3.03e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9815354 0.812 rs73830532 chr3:41898814 T/C cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.84e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg18252515 chr7:66147081 NA 0.46 5.97 0.34 7.62e-9 Aortic root size; CESC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg00074818 chr8:8560427 CLDN23 0.36 5.22 0.31 3.64e-7 Obesity-related traits; CESC cis rs734999 0.545 rs4648565 chr1:2570023 A/G cg18854424 chr1:2615690 NA -0.3 -5.88 -0.34 1.2e-8 Ulcerative colitis; CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg19536664 chr17:6899085 ALOX12 0.39 8.73 0.47 2.97e-16 Tonsillectomy; CESC cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg20503657 chr10:835505 NA 0.79 7.99 0.44 4.07e-14 Eosinophil percentage of granulocytes; CESC cis rs1865760 0.566 rs1971509 chr6:26085777 T/C cg17691542 chr6:26056736 HIST1H1C 0.42 5.57 0.32 6.13e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10534439 chr2:69969029 ANXA4 0.7 8.38 0.46 3.08e-15 Gut microbiome composition (summer); CESC cis rs11122272 0.525 rs2749713 chr1:231537921 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.08 0.35 4.28e-9 Hemoglobin concentration; CESC cis rs9788682 0.748 rs569207 chr15:78873119 A/G cg24631222 chr15:78858424 CHRNA5 -0.8 -10.06 -0.53 2.25e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs8067545 0.611 rs2703786 chr17:20156369 T/C cg13482628 chr17:19912719 NA -0.41 -5.51 -0.32 8.66e-8 Schizophrenia; CESC cis rs2760061 0.598 rs605410 chr1:228116281 A/G cg02753203 chr1:228287806 NA -0.49 -7.18 -0.4 7.11e-12 Diastolic blood pressure; CESC cis rs7833986 0.501 rs72653981 chr8:57027814 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.57 7.28 0.41 3.83e-12 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19905880 chr11:67049324 ADRBK1 -0.52 -6.08 -0.35 4.15e-9 Gut microbiome composition (summer); CESC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg13175981 chr1:150552382 MCL1 0.62 9.02 0.48 3.95e-17 Lymphocyte counts; CESC cis rs9318086 0.901 rs7336730 chr13:24452104 T/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.41 -5.97 -0.34 7.55e-9 Myopia (pathological); CESC cis rs992157 0.798 rs10206064 chr2:219157959 T/C cg00012203 chr2:219082015 ARPC2 0.75 9.7 0.51 3.1e-19 Colorectal cancer; CESC cis rs12142240 0.698 rs45449893 chr1:46859024 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.27 0.45 6.54e-15 Menopause (age at onset); CESC trans rs9467711 0.606 rs9379899 chr6:26603015 T/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.73 6.12 0.35 3.38e-9 Autism spectrum disorder or schizophrenia; CESC cis rs6484504 0.532 rs1929019 chr11:31267030 C/T cg14844989 chr11:31128820 NA -0.41 -5.82 -0.34 1.73e-8 Red blood cell count; CESC cis rs8072100 0.905 rs9895274 chr17:45539117 C/T cg25173405 chr17:45401733 C17orf57 -0.41 -5.49 -0.32 9.29e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10824722 chr1:206506826 NA 0.45 6.74 0.38 9.94e-11 Fibrinogen levels; CESC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg02187348 chr16:89574699 SPG7 0.64 9.02 0.48 4.03e-17 Multiple myeloma (IgH translocation); CESC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.51 -0.37 3.7e-10 Bipolar disorder; CESC cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg12386194 chr3:101231763 SENP7 0.45 5.6 0.33 5.44e-8 Colorectal cancer; CESC cis rs2380220 0.935 rs7744491 chr6:95994980 T/G cg04719120 chr6:96025338 MANEA 0.55 5.4 0.32 1.45e-7 Behavioural disinhibition (generation interaction); CESC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC trans rs5758511 0.731 rs58302269 chr22:42351309 G/A cg15080870 chr19:47770746 CCDC9 0.5 6.19 0.36 2.26e-9 Birth weight; CESC cis rs1707322 0.648 rs4439382 chr1:46150805 C/T cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg06494592 chr3:125709126 NA -0.5 -5.51 -0.32 8.69e-8 Blood pressure (smoking interaction); CESC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg18402987 chr7:1209562 NA 0.57 6.64 0.38 1.72e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs881375 0.702 rs3761847 chr9:123690239 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.57 0.32 6.41e-8 Rheumatoid arthritis; CESC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC trans rs561341 1.000 rs117029332 chr17:30266085 C/G cg27661571 chr11:113659931 NA -0.83 -7.82 -0.43 1.26e-13 Hip circumference adjusted for BMI; CESC cis rs17253792 0.822 rs117050012 chr14:56038729 G/T cg01858014 chr14:56050164 KTN1 -0.99 -7.46 -0.42 1.21e-12 Putamen volume; CESC cis rs7216064 0.953 rs62086044 chr17:65970837 G/T cg07042672 chr17:66097459 LOC651250 -0.58 -6.52 -0.37 3.49e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08255233 chr6:87607178 NA -0.58 -7.64 -0.42 3.85e-13 Gut microbiome composition (summer); CESC cis rs7116495 1.000 rs493065 chr11:71796929 T/C cg26138937 chr11:71823887 C11orf51 -0.86 -7.03 -0.4 1.75e-11 Severe influenza A (H1N1) infection; CESC cis rs11098499 0.954 rs6834796 chr4:120414693 A/C cg09307838 chr4:120376055 NA 0.93 13.06 0.63 2.03e-30 Corneal astigmatism; CESC cis rs7927592 0.913 rs11228276 chr11:68307525 A/G cg20283391 chr11:68216788 NA -0.62 -7.45 -0.42 1.31e-12 Total body bone mineral density; CESC cis rs668210 0.793 rs622779 chr11:65744247 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.66 -6.52 -0.37 3.55e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7247513 0.639 rs12984441 chr19:12760287 A/C cg01871581 chr19:12707946 ZNF490 -0.81 -12.65 -0.61 5.37e-29 Bipolar disorder; CESC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -7.04 -0.4 1.69e-11 Extrinsic epigenetic age acceleration; CESC trans rs677673 1.000 rs67438213 chr20:10476532 T/G cg16021678 chr13:55475951 NA 0.51 6.4 0.37 7.15e-10 Body mass index (change over time) in chronic obstructive pulmonary disease; CESC cis rs3820068 0.581 rs6692461 chr1:15928449 A/G cg17385448 chr1:15911702 AGMAT 0.44 7.16 0.4 7.97e-12 Systolic blood pressure; CESC cis rs9611519 0.780 rs1983631 chr22:41644074 C/T cg03806693 chr22:41940476 POLR3H -0.69 -7.8 -0.43 1.38e-13 Neuroticism; CESC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.57 6.99 0.39 2.29e-11 Height; CESC cis rs796364 0.906 rs281789 chr2:200780698 T/G cg23649088 chr2:200775458 C2orf69 0.56 5.26 0.31 3e-7 Schizophrenia; CESC cis rs9513627 0.833 rs4605005 chr13:100132471 T/C cg25919922 chr13:100150906 NA 0.68 5.77 0.33 2.16e-8 Obesity-related traits; CESC cis rs6598955 0.617 rs11247883 chr1:26576247 T/G cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07207937 chr4:78783799 MRPL1 -0.55 -6.11 -0.35 3.45e-9 Gut microbiome composition (summer); CESC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.68 0.33 3.59e-8 Bipolar disorder; CESC trans rs9354308 0.901 rs2814121 chr6:66566915 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 7.96 0.44 5.21e-14 Metabolite levels; CESC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg23758822 chr17:41437982 NA 1.01 15.25 0.68 3.9e-38 Menopause (age at onset); CESC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg02269571 chr22:50332266 NA -0.57 -6.99 -0.39 2.29e-11 Schizophrenia; CESC cis rs6540556 0.769 rs627670 chr1:209929299 G/A cg05527609 chr1:210001259 C1orf107 0.49 5.89 0.34 1.17e-8 Red blood cell count; CESC cis rs11190604 1.000 rs11190556 chr10:102209223 G/A cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs4969178 0.965 rs8072632 chr17:76397830 T/C cg20026190 chr17:76395443 PGS1 0.49 7.79 0.43 1.51e-13 HDL cholesterol levels; CESC cis rs644799 0.648 rs1255176 chr11:95471465 A/T cg25622487 chr11:95524042 FAM76B;CEP57 0.42 5.73 0.33 2.78e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2228479 0.867 rs62052185 chr16:89969254 C/T cg14709524 chr16:89940631 TCF25 0.72 5.44 0.32 1.24e-7 Skin colour saturation; CESC cis rs3008870 1.000 rs6673462 chr1:67461857 A/C cg02640540 chr1:67518911 SLC35D1 -0.51 -5.58 -0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs7824557 0.806 rs7007394 chr8:11094566 G/A cg21775007 chr8:11205619 TDH -0.36 -5.21 -0.31 3.73e-7 Retinal vascular caliber; CESC cis rs7116495 0.609 rs4387373 chr11:71774908 A/G cg26138937 chr11:71823887 C11orf51 -1.32 -8.2 -0.45 1.04e-14 Severe influenza A (H1N1) infection; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16682046 chr11:82612617 PRCP;C11orf82 0.47 6.0 0.35 6.52e-9 Gut microbiota (bacterial taxa); CESC cis rs2072732 0.904 rs12044831 chr1:2964397 A/C cg15211996 chr1:2936768 ACTRT2 0.34 5.44 0.32 1.2e-7 Plateletcrit; CESC cis rs7116495 1.000 rs10793016 chr11:71755063 A/G cg26138937 chr11:71823887 C11orf51 0.76 6.44 0.37 5.6e-10 Severe influenza A (H1N1) infection; CESC cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg08392591 chr16:89556376 ANKRD11 -0.38 -5.06 -0.3 7.77e-7 Multiple myeloma (IgH translocation); CESC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg08470875 chr2:26401718 FAM59B 0.75 7.82 0.43 1.26e-13 Gut microbiome composition (summer); CESC cis rs9443189 1.000 rs1280047 chr6:76527791 A/G cg01950844 chr6:76311363 SENP6 0.64 6.66 0.38 1.61e-10 Prostate cancer; CESC cis rs7809950 0.862 rs12112877 chr7:106941324 T/C cg23024343 chr7:107201750 COG5 -0.37 -5.1 -0.3 6.42e-7 Coronary artery disease; CESC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg22903471 chr2:27725779 GCKR -0.55 -7.53 -0.42 8.1e-13 Total body bone mineral density; CESC cis rs4722166 0.564 rs1800797 chr7:22766221 A/G cg05472934 chr7:22766657 IL6 0.8 10.22 0.53 6.78e-21 Lung cancer; CESC cis rs8018808 0.935 rs958463 chr14:77886721 G/T cg20045696 chr14:77926864 AHSA1 0.47 6.59 0.38 2.42e-10 Myeloid white cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25886382 chr13:26760664 NA 0.55 6.64 0.38 1.78e-10 Gut microbiome composition (summer); CESC cis rs898097 0.528 rs2243523 chr17:80680449 G/T cg05255149 chr17:80675120 FN3KRP -0.5 -6.42 -0.37 6.24e-10 Breast cancer; CESC cis rs425277 0.958 rs7546523 chr1:2043792 G/A cg16545954 chr1:2118288 C1orf86 0.32 5.25 0.31 3.15e-7 Height; CESC trans rs6542647 0.678 rs17582650 chr2:4855471 A/G cg06797068 chr6:74104600 DDX43 0.69 6.17 0.35 2.52e-9 Left ventricular obstructive tract defect (inherited effect); CESC cis rs9309473 0.950 rs6546860 chr2:73844249 G/A cg20560298 chr2:73613845 ALMS1 -0.43 -5.74 -0.33 2.55e-8 Metabolite levels; CESC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg06873352 chr17:61820015 STRADA 0.49 7.2 0.4 6.26e-12 Height; CESC cis rs7666738 0.830 rs60391193 chr4:98933912 T/G cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs72945132 0.882 rs72949078 chr11:70217708 T/C cg00319359 chr11:70116639 PPFIA1 0.76 7.17 0.4 7.33e-12 Coronary artery disease; CESC cis rs6541297 0.703 rs637180 chr1:230311677 G/A cg20703242 chr1:230279135 GALNT2 -0.43 -5.59 -0.33 5.51e-8 Coronary artery disease; CESC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.8 -0.55 9.24e-23 Alzheimer's disease; CESC cis rs9457247 1.000 rs408080 chr6:167392522 T/C cg25258033 chr6:167368657 RNASET2 0.38 5.76 0.33 2.31e-8 Crohn's disease; CESC cis rs3749237 0.595 rs7637999 chr3:49535115 C/T cg02487422 chr3:49467188 NICN1 0.56 8.19 0.45 1.09e-14 Resting heart rate; CESC cis rs12477438 0.501 rs12619780 chr2:99707307 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.35 0.63 2e-31 Chronic sinus infection; CESC cis rs2273669 0.667 rs112319185 chr6:109305318 T/C cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg26939375 chr7:64535504 NA -0.63 -8.45 -0.46 1.96e-15 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.54 6.01 0.35 5.96e-9 Gut microbiome composition (summer); CESC cis rs2635047 1.000 rs2684825 chr18:44666415 T/C cg19077165 chr18:44547161 KATNAL2 -0.45 -6.05 -0.35 5e-9 Educational attainment; CESC cis rs7605827 0.930 rs12692262 chr2:15539084 A/G cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.45e-9 Educational attainment (years of education); CESC cis rs8067354 0.645 rs2645491 chr17:57877049 C/T cg02344993 chr17:57696989 CLTC 0.67 8.28 0.45 6.3e-15 Hemoglobin concentration; CESC trans rs3942852 0.868 rs7118226 chr11:48106267 T/G cg15704280 chr7:45808275 SEPT13 -0.66 -7.67 -0.43 3.3e-13 Acute lymphoblastic leukemia (childhood); CESC trans rs61931739 0.534 rs1852222 chr12:34008665 C/A cg26384229 chr12:38710491 ALG10B 0.48 6.57 0.37 2.6e-10 Morning vs. evening chronotype; CESC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg11644478 chr21:40555479 PSMG1 -0.82 -12.16 -0.6 2.48e-27 Cognitive function; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg08126158 chr2:183963421 DUSP19 0.39 6.13 0.35 3.23e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg05564831 chr3:52568323 NT5DC2 0.46 7.34 0.41 2.57e-12 Electroencephalogram traits; CESC cis rs763014 0.898 rs8060921 chr16:635988 C/A cg07343612 chr16:622815 PIGQ -0.55 -7.99 -0.44 4.25e-14 Height; CESC cis rs8038465 0.622 rs710086 chr15:73877001 C/T cg15420318 chr15:73925796 NPTN 0.49 6.93 0.39 3.26e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12142240 0.698 rs45517837 chr1:46859225 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.27 0.45 6.54e-15 Menopause (age at onset); CESC cis rs9303401 0.580 rs34076823 chr17:57114497 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.86 10.68 0.55 2.3e-22 Cognitive test performance; CESC cis rs6580649 0.882 rs2286022 chr12:48436647 G/A cg05342945 chr12:48394962 COL2A1 0.53 6.0 0.35 6.38e-9 Lung cancer; CESC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.16 -0.3 4.96e-7 Obesity-related traits; CESC cis rs8060686 0.545 rs12444188 chr16:68282077 G/A cg26727032 chr16:67993705 SLC12A4 -0.52 -5.6 -0.33 5.23e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs3733585 0.699 rs6844787 chr4:9959233 A/G cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg11764359 chr7:65958608 NA -0.63 -8.0 -0.44 4.01e-14 Aortic root size; CESC cis rs11792861 0.619 rs2289480 chr9:111705501 A/C cg13535736 chr9:111863775 C9orf5 -0.39 -5.67 -0.33 3.82e-8 Menarche (age at onset); CESC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg05564831 chr3:52568323 NT5DC2 0.47 7.34 0.41 2.68e-12 Electroencephalogram traits; CESC trans rs7824557 0.510 rs4841524 chr8:11243126 C/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.05 -0.35 4.95e-9 Retinal vascular caliber; CESC cis rs9583531 0.600 rs6492306 chr13:111361693 G/A cg24331049 chr13:111365604 ING1 0.71 10.89 0.56 4.48e-23 Coronary artery disease; CESC cis rs2228479 1.000 rs62052180 chr16:89963289 C/G cg04013166 chr16:89971882 TCF25 0.76 6.94 0.39 3.06e-11 Skin colour saturation; CESC cis rs4594175 0.926 rs114230179 chr14:51601974 C/T cg23942311 chr14:51606299 NA 0.4 5.94 0.34 9.07e-9 Cancer; CESC cis rs7973683 0.541 rs6488910 chr12:124393697 G/T cg00084347 chr12:124393913 DNAH10 0.29 6.19 0.36 2.23e-9 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.58 -7.33 -0.41 2.75e-12 Height; CESC cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg08736216 chr1:53307985 ZYG11A 0.3 5.05 0.3 8.16e-7 Monocyte count; CESC cis rs3617 0.591 rs11918800 chr3:52868145 G/A cg11645453 chr3:52864694 ITIH4 -0.26 -5.18 -0.3 4.48e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs72781680 0.752 rs72796119 chr2:23917179 C/T cg08917208 chr2:24149416 ATAD2B 1.13 10.24 0.53 5.87e-21 Lymphocyte counts; CESC cis rs6831352 0.918 rs7670060 chr4:100059568 G/T cg13256891 chr4:100009986 ADH5 -0.77 -8.49 -0.46 1.5e-15 Alcohol dependence; CESC cis rs28374715 0.578 rs7165914 chr15:41632451 C/T cg20272979 chr15:41787780 ITPKA 0.46 5.5 0.32 8.78e-8 Ulcerative colitis; CESC cis rs7000551 0.715 rs2443502 chr8:22340499 G/A cg12081754 chr8:22256438 SLC39A14 0.4 5.31 0.31 2.34e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC trans rs9951602 0.512 rs9946138 chr18:76654608 A/G cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs9894429 0.646 rs6565609 chr17:79592267 G/A cg21984481 chr17:79567631 NPLOC4 -0.34 -5.19 -0.3 4.21e-7 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15238467 chr12:57522045 LRP1 0.55 6.06 0.35 4.64e-9 Gut microbiome composition (summer); CESC cis rs870825 0.549 rs28579266 chr4:185627262 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs425277 1.000 rs262657 chr1:2088577 G/A cg24578937 chr1:2090814 PRKCZ 0.55 9.53 0.51 1.09e-18 Height; CESC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg00149659 chr3:10157352 C3orf10 0.72 8.61 0.47 6.41e-16 Alzheimer's disease; CESC cis rs7762018 1.000 rs74900588 chr6:170102180 A/C cg13891659 chr6:170190454 C6orf122;C6orf208 0.55 5.7 0.33 3.26e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9768139 0.708 rs10234067 chr7:158114542 C/T cg25566285 chr7:158114605 PTPRN2 0.54 9.09 0.49 2.33e-17 Calcium levels; CESC cis rs62344088 0.590 rs2115276 chr5:169829 C/G cg22857025 chr5:266934 NA -1.2 -8.17 -0.45 1.24e-14 Asthma (childhood onset); CESC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg26119090 chr2:26468346 HADHA;HADHB -1.09 -13.46 -0.64 8.09e-32 Gut microbiome composition (summer); CESC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.51 -0.32 8.59e-8 Huntington's disease progression; CESC cis rs5995756 0.761 rs1534883 chr22:40005425 T/C cg03390717 chr22:39966585 CACNA1I -0.36 -6.18 -0.35 2.4e-9 Autism spectrum disorder or schizophrenia; CESC cis rs12477438 0.798 rs2309524 chr2:99659510 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -11.0 -0.56 1.96e-23 Chronic sinus infection; CESC cis rs9911578 0.935 rs2302189 chr17:56584205 A/C cg12560992 chr17:57184187 TRIM37 -0.92 -14.34 -0.66 6.66e-35 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg26335602 chr6:28129616 ZNF389 0.53 6.82 0.39 6.19e-11 Depression; CESC cis rs6942756 1.000 rs2012919 chr7:128890812 C/T cg02491457 chr7:128862824 NA -0.7 -10.09 -0.53 1.75e-20 White matter hyperintensity burden; CESC cis rs10782582 0.593 rs79552201 chr1:76215497 A/T cg22875332 chr1:76189707 ACADM -0.45 -5.32 -0.31 2.19e-7 Daytime sleep phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16479401 chr4:83956051 COPS4 -0.57 -6.61 -0.38 2.15e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg04944784 chr2:26401820 FAM59B -0.91 -10.44 -0.54 1.36e-21 Gut microbiome composition (summer); CESC cis rs9486719 1.000 rs2145535 chr6:97034715 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -8.21 -0.45 9.56e-15 Migraine;Coronary artery disease; CESC cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg22875332 chr1:76189707 ACADM 0.69 9.3 0.5 5.49e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1371867 0.846 rs1660327 chr8:101292206 A/C cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.24e-11 Atrioventricular conduction; CESC cis rs7914558 0.933 rs1538204 chr10:104733893 T/A cg04362960 chr10:104952993 NT5C2 0.45 5.76 0.33 2.33e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs11122272 0.701 rs2883799 chr1:231531166 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs17125944 0.615 rs17125798 chr14:53319905 G/A cg00686598 chr14:53173677 PSMC6 0.98 7.08 0.4 1.29e-11 Alzheimer's disease (late onset); CESC cis rs1034435 0.755 rs6007871 chr22:48894392 C/G cg05992904 chr22:48892994 FAM19A5 -0.57 -9.64 -0.51 4.75e-19 Late-onset Alzheimer's disease; CESC cis rs501120 0.929 rs605425 chr10:44750669 T/C cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.12e-11 Coronary artery disease;Coronary heart disease; CESC cis rs67311347 1.000 rs73080138 chr3:40516417 A/G cg01475735 chr3:40494733 NA -0.42 -5.4 -0.32 1.46e-7 Renal cell carcinoma; CESC cis rs763121 0.853 rs5750627 chr22:38982321 A/G cg06022373 chr22:39101656 GTPBP1 0.93 16.41 0.71 2.96e-42 Menopause (age at onset); CESC cis rs6598955 0.724 rs12754536 chr1:26639605 T/C cg00852783 chr1:26633632 UBXN11 0.43 6.31 0.36 1.14e-9 Obesity-related traits; CESC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg00149659 chr3:10157352 C3orf10 0.72 9.27 0.49 6.61e-18 Alzheimer's disease; CESC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg09365446 chr1:150670422 GOLPH3L 0.39 5.11 0.3 6.21e-7 Melanoma; CESC cis rs4843747 0.636 rs4075597 chr16:88107590 C/A cg17633681 chr16:88106987 BANP 0.72 9.54 0.51 9.75e-19 Menopause (age at onset); CESC cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg05347473 chr6:146136440 FBXO30 0.59 7.63 0.42 4.24e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs698833 0.669 rs1584885 chr2:44647038 A/C cg02912187 chr19:18314776 RAB3A -0.44 -6.03 -0.35 5.55e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.44 0.32 1.2e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2710642 0.545 rs1406002 chr2:62807091 A/C cg17519650 chr2:63277830 OTX1 0.47 6.26 0.36 1.53e-9 LDL cholesterol levels;LDL cholesterol; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13415434 chr3:49044522 P4HTM;WDR6 0.47 6.03 0.35 5.43e-9 Gut microbiota (bacterial taxa); CESC trans rs76747430 0.528 rs5750913 chr22:40640285 A/G cg26752003 chr8:145688521 CYHR1 0.48 6.07 0.35 4.33e-9 Facial morphology (factor 20); CESC cis rs6032067 0.929 rs6032044 chr20:43819416 C/A cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.53e-7 Blood protein levels; CESC cis rs9300255 0.739 rs10846491 chr12:123753492 C/G cg05973401 chr12:123451056 ABCB9 0.51 5.88 0.34 1.24e-8 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19726959 chr15:75094782 CSK -0.52 -6.14 -0.35 3.05e-9 Gut microbiome composition (summer); CESC cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg23711669 chr6:146136114 FBXO30 0.94 14.11 0.66 4.13e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs2046867 0.818 rs1502757 chr3:72864161 C/T cg25664220 chr3:72788482 NA -0.47 -6.89 -0.39 4.1e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs1059312 1.000 rs7135854 chr12:129279988 G/C cg09035930 chr12:129282057 SLC15A4 0.76 10.73 0.55 1.59e-22 Systemic lupus erythematosus; CESC cis rs12042052 1.000 rs72754230 chr1:232935071 A/G cg06935979 chr1:232941706 KIAA1383 0.75 6.09 0.35 4.02e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs367943 0.712 rs26961 chr5:112736779 A/G cg12552261 chr5:112820674 MCC 0.4 5.32 0.31 2.21e-7 Type 2 diabetes; CESC cis rs7107174 1.000 rs10899467 chr11:78014057 G/T cg02023728 chr11:77925099 USP35 0.43 5.66 0.33 4e-8 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11792861 0.591 rs2275641 chr9:111696389 G/C cg05043794 chr9:111880884 C9orf5 -0.3 -5.43 -0.32 1.28e-7 Menarche (age at onset); CESC cis rs35110281 0.666 rs2838348 chr21:45107285 C/G cg04455712 chr21:45112962 RRP1B -0.48 -7.52 -0.42 8.48e-13 Mean corpuscular volume; CESC cis rs1957429 0.901 rs1957435 chr14:65349697 G/A cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC cis rs11123694 1.000 rs11123694 chr2:109064563 C/T cg01745370 chr2:109065127 GCC2 0.37 5.61 0.33 5.02e-8 Mean platelet volume; CESC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg04369109 chr6:150039330 LATS1 -0.4 -5.4 -0.31 1.48e-7 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17740632 chr19:58892104 ZNF837 -0.45 -6.21 -0.36 2.03e-9 Fibrinogen levels; CESC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg18876405 chr7:65276391 NA -0.59 -7.97 -0.44 4.6e-14 Aortic root size; CESC cis rs6963495 0.818 rs56055535 chr7:105163574 C/A cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17902007 chr13:101184847 A2LD1 -0.62 -7.06 -0.4 1.43e-11 Gut microbiome composition (summer); CESC cis rs7520050 0.807 rs4660312 chr1:46110572 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.95 0.34 8.33e-9 Red blood cell count;Reticulocyte count; CESC cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg10523679 chr1:76189770 ACADM 0.77 10.51 0.54 8.08e-22 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7605827 0.897 rs4668922 chr2:15675130 C/T cg19274914 chr2:15703543 NA 0.38 6.79 0.38 7.31e-11 Educational attainment (years of education); CESC cis rs714031 0.934 rs5757768 chr22:40071322 G/A cg21377881 chr22:40064566 CACNA1I -0.4 -6.47 -0.37 4.69e-10 Schizophrenia; CESC cis rs9811920 0.609 rs793467 chr3:99539664 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 5.73 0.33 2.79e-8 Axial length; CESC cis rs11098499 0.865 rs28753180 chr4:120405367 A/T cg09307838 chr4:120376055 NA 0.93 13.07 0.63 1.78e-30 Corneal astigmatism; CESC cis rs9486719 1.000 rs9373978 chr6:97056255 T/C cg18709589 chr6:96969512 KIAA0776 -0.52 -5.71 -0.33 3.09e-8 Migraine;Coronary artery disease; CESC cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg25019033 chr10:957182 NA -0.56 -5.57 -0.32 6.34e-8 Eosinophil percentage of granulocytes; CESC cis rs6963495 0.818 rs56177071 chr7:105165648 C/T cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs2573652 1.000 rs7163481 chr15:100516916 C/G cg09918751 chr15:100517450 ADAMTS17 0.42 8.07 0.44 2.39e-14 Height; CESC cis rs9926296 0.542 rs12599531 chr16:89909401 C/T cg27121462 chr16:89883253 FANCA -0.51 -6.1 -0.35 3.66e-9 Vitiligo; CESC cis rs12478296 0.901 rs73007142 chr2:243010852 T/C cg06360820 chr2:242988706 NA -1.04 -10.22 -0.53 7.03e-21 Obesity-related traits; CESC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg15445000 chr17:37608096 MED1 -0.39 -5.95 -0.34 8.41e-9 Glomerular filtration rate (creatinine); CESC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg11859384 chr17:80120422 CCDC57 0.38 5.21 0.3 3.88e-7 Life satisfaction; CESC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg11657440 chr19:46296263 DMWD 0.77 11.86 0.59 2.57e-26 Coronary artery disease; CESC cis rs75477785 0.590 rs72649949 chr1:210244351 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.23 0.36 1.82e-9 Cleft lip with or without cleft palate; CESC cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg16262614 chr3:133464971 TF -0.39 -7.78 -0.43 1.66e-13 Iron status biomarkers (transferrin levels); CESC cis rs6582630 0.599 rs8189525 chr12:38424982 A/C cg26384229 chr12:38710491 ALG10B 0.41 5.58 0.32 6.04e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs7917772 0.545 rs3934960 chr10:104355275 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.4 -5.4 -0.31 1.49e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs854765 0.619 rs4561528 chr17:17979099 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.51 6.52 0.37 3.59e-10 Total body bone mineral density; CESC cis rs7089973 0.604 rs11196936 chr10:116588630 C/T cg03647239 chr10:116582469 FAM160B1 0.43 5.29 0.31 2.6e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7674212 0.539 rs6533056 chr4:104120997 T/C cg16532752 chr4:104119610 CENPE -0.4 -5.48 -0.32 1.01e-7 Type 2 diabetes; CESC cis rs9303401 0.573 rs35104446 chr17:57180234 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.89 11.2 0.57 4.21e-24 Cognitive test performance; CESC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg13264159 chr8:625131 ERICH1 -0.69 -5.15 -0.3 5.02e-7 IgG glycosylation; CESC cis rs9291683 0.552 rs10939655 chr4:10014642 A/T cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.7e-37 Bone mineral density; CESC cis rs2180341 1.000 rs6904520 chr6:127629802 T/C cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6e-39 Breast cancer; CESC cis rs6088580 0.524 rs6087612 chr20:33230822 T/G cg08999081 chr20:33150536 PIGU -0.44 -6.19 -0.36 2.33e-9 Glomerular filtration rate (creatinine); CESC cis rs2276314 1.000 rs9304154 chr18:33562227 C/T cg19628046 chr18:33552617 C18orf21 0.53 5.72 0.33 2.83e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs6963495 0.872 rs1569134 chr7:105158228 T/C cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs748404 0.631 rs2467745 chr15:43722742 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.62 0.42 4.42e-13 Lung cancer; CESC cis rs2732480 0.517 rs2634676 chr12:48738236 A/G cg04545296 chr12:48745243 ZNF641 0.44 7.23 0.41 5.12e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9790314 1.000 rs7653233 chr3:160992033 G/A cg03342759 chr3:160939853 NMD3 -0.53 -7.24 -0.41 4.97e-12 Morning vs. evening chronotype; CESC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg11764359 chr7:65958608 NA 0.96 15.27 0.68 3.49e-38 Aortic root size; CESC cis rs7914558 0.505 rs12260436 chr10:104741114 A/C cg04362960 chr10:104952993 NT5C2 0.53 6.29 0.36 1.33e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6570726 0.935 rs390252 chr6:145856896 A/G cg23711669 chr6:146136114 FBXO30 0.8 11.74 0.58 6.58e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs889398 0.802 rs12598642 chr16:69848772 A/G cg09409435 chr16:70099608 PDXDC2 -0.4 -5.06 -0.3 7.91e-7 Body mass index; CESC cis rs6835098 1.000 rs28477433 chr4:174085820 T/C cg08422745 chr4:174089978 GALNT7 -0.84 -12.19 -0.6 1.92e-27 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs208520 0.690 rs12208977 chr6:66725257 G/A cg07460842 chr6:66804631 NA 0.96 12.77 0.62 2e-29 Exhaled nitric oxide output; CESC cis rs7247513 0.639 rs12984441 chr19:12760287 A/C cg06417478 chr19:12876846 HOOK2 0.43 5.36 0.31 1.86e-7 Bipolar disorder; CESC cis rs2243480 1.000 rs34815098 chr7:65292254 A/C cg18252515 chr7:66147081 NA -1.01 -9.72 -0.51 2.6e-19 Diabetic kidney disease; CESC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg23590916 chr17:43697445 MGC57346 0.65 6.44 0.37 5.62e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3738443 0.594 rs6664697 chr1:247380610 A/T cg07706540 chr1:247373924 NA 0.47 5.74 0.33 2.61e-8 Alcohol dependence; CESC cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg06027949 chr8:82754900 SNX16 -0.44 -5.24 -0.31 3.31e-7 Diastolic blood pressure; CESC cis rs4660306 1.000 rs2993259 chr1:46001550 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.6 -7.53 -0.42 8.05e-13 Homocysteine levels; CESC cis rs4243830 0.850 rs1114661 chr1:6596871 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.98 -9.9 -0.52 7.19e-20 Body mass index; CESC cis rs6732160 0.691 rs2007191 chr2:73421463 T/G cg01422370 chr2:73384389 NA 0.43 7.29 0.41 3.57e-12 Intelligence (multi-trait analysis); CESC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg25767906 chr1:53392781 SCP2 0.43 6.06 0.35 4.75e-9 Monocyte count; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg04621255 chr9:131581398 ENDOG 0.44 6.01 0.35 5.98e-9 Weight; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15739904 chr8:125313885 NA -0.48 -6.37 -0.36 8.35e-10 Asthma; CESC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg09658497 chr7:2847517 GNA12 -0.43 -6.15 -0.35 2.77e-9 Height; CESC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg23590916 chr17:43697445 MGC57346 0.65 6.58 0.37 2.51e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00292435 chr9:91925643 CKS2 -0.43 -6.35 -0.36 9.2e-10 Gambling; CESC cis rs11098499 0.913 rs35271032 chr4:120156659 C/T cg09307838 chr4:120376055 NA 0.87 11.45 0.58 6.04e-25 Corneal astigmatism; CESC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -5.09 -0.3 6.71e-7 Developmental language disorder (linguistic errors); CESC cis rs2204008 0.576 rs11519979 chr12:37999413 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.71 0.55 1.77e-22 Bladder cancer; CESC cis rs1580019 0.922 rs59938271 chr7:32484844 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.89 12.23 0.6 1.43e-27 Cognitive ability; CESC cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -9.2 -0.49 1.12e-17 Mean corpuscular volume; CESC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg14949292 chr17:78079608 GAA 0.36 5.13 0.3 5.5e-7 Yeast infection; CESC cis rs7165102 0.895 rs1699937 chr15:65791579 T/C cg11441148 chr15:65824328 PTPLAD1 -0.31 -5.21 -0.3 3.74e-7 Mean corpuscular hemoglobin; CESC cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.76e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg09365446 chr1:150670422 GOLPH3L 0.4 5.31 0.31 2.34e-7 Melanoma; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20617956 chr10:82168530 C10orf58 -0.47 -6.65 -0.38 1.64e-10 Height; CESC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg22105103 chr4:187893119 NA 0.49 6.86 0.39 4.89e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs8017423 0.935 rs7158410 chr14:90704370 T/C cg14092571 chr14:90743983 NA -0.56 -8.31 -0.45 4.95e-15 Mortality in heart failure; CESC cis rs748404 0.660 rs694725 chr15:43756210 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.49 0.42 1.01e-12 Lung cancer; CESC cis rs10752881 1.000 rs10797802 chr1:182973158 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.85 -13.52 -0.64 4.8e-32 Colorectal cancer; CESC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg18032046 chr6:28092343 ZSCAN16 -0.53 -5.74 -0.33 2.55e-8 Parkinson's disease; CESC cis rs2204008 0.748 rs7312204 chr12:38334909 T/C cg26384229 chr12:38710491 ALG10B 0.65 9.63 0.51 5.06e-19 Bladder cancer; CESC cis rs57506017 0.585 rs1020006 chr7:12255664 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.36e-7 Neuroticism; CESC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.87 -11.68 -0.58 1.08e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs116095464 0.558 rs6555055 chr5:226160 A/C cg10591111 chr5:226296 SDHA -0.53 -6.61 -0.38 2.15e-10 Breast cancer; CESC cis rs11650494 0.831 rs73324348 chr17:47455752 G/A cg08112188 chr17:47440006 ZNF652 1.04 8.0 0.44 3.86e-14 Prostate cancer; CESC cis rs6543140 0.964 rs1523206 chr2:103070175 A/T cg04239558 chr2:103089729 SLC9A4 0.47 5.99 0.35 6.67e-9 Blood protein levels; CESC trans rs941207 0.542 rs2888095 chr12:57187473 C/T cg26462586 chr2:11164677 NA 0.38 6.02 0.35 5.82e-9 Platelet count; CESC cis rs6732160 0.574 rs1991612 chr2:73480501 G/C cg01422370 chr2:73384389 NA 0.44 7.54 0.42 7.49e-13 Intelligence (multi-trait analysis); CESC cis rs1065852 0.526 rs2097562 chr22:42389500 T/C cg22189786 chr22:42395067 WBP2NL 0.43 5.42 0.32 1.33e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC trans rs1373453 0.908 rs2277389 chr12:70066856 C/T cg19702771 chr4:82058885 PRKG2 0.74 6.04 0.35 5.28e-9 Orofacial clefts; CESC cis rs854765 0.964 rs854764 chr17:18011750 A/G cg16928487 chr17:17741425 SREBF1 0.61 9.81 0.52 1.41e-19 Total body bone mineral density; CESC cis rs2243480 1.000 rs781142 chr7:65438778 C/T cg13147721 chr7:65941812 NA -0.87 -8.63 -0.47 5.76e-16 Diabetic kidney disease; CESC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.66 9.22 0.49 9.27e-18 Menopause (age at onset); CESC cis rs76878669 0.561 rs4930362 chr11:66154360 T/C cg18002602 chr11:66138449 SLC29A2 0.4 6.76 0.38 8.68e-11 Educational attainment (years of education); CESC cis rs2425143 0.818 rs73902932 chr20:34489009 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.87 0.34 1.33e-8 Blood protein levels; CESC cis rs4604732 0.588 rs74154678 chr1:247626202 A/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9910055 0.573 rs113184718 chr17:42206543 A/T cg13607699 chr17:42295918 UBTF -0.6 -7.82 -0.43 1.23e-13 Total body bone mineral density; CESC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg14829155 chr15:31115871 NA -0.71 -9.41 -0.5 2.52e-18 Huntington's disease progression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15427160 chr3:186524114 RFC4 0.57 6.05 0.35 4.86e-9 Gut microbiome composition (summer); CESC cis rs12530845 1.000 rs56060450 chr7:135331777 C/T cg23117316 chr7:135346802 PL-5283 -0.41 -5.29 -0.31 2.52e-7 Red blood cell traits; CESC cis rs4803455 0.565 rs2241713 chr19:41869468 C/G cg09537434 chr19:41945824 ATP5SL 0.69 9.91 0.52 6.84e-20 Migraine;Coronary artery disease; CESC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.68 0.61 4e-29 Gut microbiome composition (summer); CESC cis rs2354432 0.891 rs2165743 chr1:146690319 C/T cg25205988 chr1:146714368 CHD1L 1.08 11.4 0.57 8.97e-25 Mitochondrial DNA levels; CESC cis rs287982 1.000 rs287979 chr2:9970967 T/C cg10881225 chr2:9984929 TAF1B -0.39 -5.12 -0.3 5.88e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs12121840 0.790 rs16847083 chr1:165534130 C/T cg16553119 chr1:165599451 MGST3 0.43 5.04 0.3 8.72e-7 Interleukin-1-receptor antagonist levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00383909 chr3:49044727 WDR6 -0.62 -7.02 -0.4 1.86e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19598685 chr12:109592525 ACACB 0.57 6.9 0.39 3.87e-11 Gut microbiome composition (summer); CESC cis rs6460942 1.000 rs117657017 chr7:12318891 T/C cg20607287 chr7:12443886 VWDE -0.79 -8.51 -0.46 1.32e-15 Coronary artery disease; CESC cis rs8002861 0.846 rs56408817 chr13:44471983 A/G cg14210620 chr13:44453864 C13orf31;CCDC122 -0.44 -5.48 -0.32 9.92e-8 Leprosy; CESC cis rs4835473 0.932 rs6843671 chr4:144693194 T/G cg25736465 chr4:144833511 NA -0.33 -5.15 -0.3 5e-7 Immature fraction of reticulocytes; CESC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs751728 0.664 rs6929696 chr6:33759290 C/T cg25922239 chr6:33757077 LEMD2 -0.43 -6.01 -0.35 6.02e-9 Crohn's disease; CESC cis rs7208859 0.573 rs216443 chr17:28931871 A/G cg19761014 chr17:28927070 LRRC37B2 0.81 6.39 0.37 7.41e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7520050 0.807 rs28844317 chr1:46209207 T/C cg24296786 chr1:45957014 TESK2 -0.48 -6.19 -0.36 2.27e-9 Red blood cell count;Reticulocyte count; CESC cis rs17253792 0.822 rs17747083 chr14:56110594 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.79 6.04 0.35 5.13e-9 Putamen volume; CESC cis rs7665939 0.932 rs66626876 chr4:190101569 T/G cg14840187 chr4:190284988 NA -0.64 -6.6 -0.38 2.28e-10 Amyotrophic lateral sclerosis; CESC cis rs1048238 0.818 rs945421 chr1:16345393 T/C cg21214613 chr1:16344536 HSPB7 0.32 5.25 0.31 3.08e-7 Systolic blood pressure; CESC cis rs9911578 0.967 rs302842 chr17:56728102 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC cis rs8018808 1.000 rs4899652 chr14:77848972 A/G cg20045696 chr14:77926864 AHSA1 -0.43 -5.81 -0.34 1.82e-8 Myeloid white cell count; CESC cis rs2996428 0.667 rs11576900 chr1:3770914 A/G cg13057898 chr1:3703894 LRRC47 0.44 5.98 0.34 7.28e-9 Red cell distribution width; CESC cis rs1355223 0.545 rs12278318 chr11:34876507 C/G cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.59 -0.38 2.37e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7264396 0.690 rs2425171 chr20:34443173 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.51 -0.58 3.81e-25 Total cholesterol levels; CESC trans rs3780486 0.846 rs2209948 chr9:33138247 G/A cg04842962 chr6:43655489 MRPS18A 1.0 18.82 0.76 9.47e-51 IgG glycosylation; CESC cis rs2073300 0.609 rs6132617 chr20:23420151 G/C cg12062639 chr20:23401060 NAPB 0.89 7.28 0.41 3.91e-12 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7212590 0.748 rs7223057 chr17:57936438 G/C cg20303301 chr17:57937339 TUBD1 -0.53 -5.24 -0.31 3.3e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs9916302 0.718 rs10445306 chr17:37591422 A/G cg00129232 chr17:37814104 STARD3 -0.56 -7.4 -0.41 1.85e-12 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg03467027 chr4:99064603 C4orf37 0.47 5.94 0.34 8.77e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7274811 0.744 rs209665 chr20:32128889 T/G cg21523528 chr20:32077966 CBFA2T2 0.43 5.21 0.31 3.73e-7 Height; CESC cis rs9815354 1.000 rs9875083 chr3:41775786 T/A cg03022575 chr3:42003672 ULK4 0.55 5.41 0.32 1.39e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs11098499 0.908 rs11098527 chr4:120399906 A/G cg09307838 chr4:120376055 NA 0.92 12.88 0.62 8.65e-30 Corneal astigmatism; CESC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg04553112 chr3:125709451 NA -0.54 -5.82 -0.34 1.71e-8 Blood pressure (smoking interaction); CESC cis rs7914558 0.966 rs10450373 chr10:104728616 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.74 0.33 2.57e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs708547 0.647 rs1718830 chr4:57888510 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.48 6.67 0.38 1.48e-10 Response to bleomycin (chromatid breaks); CESC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Parkinson's disease; CESC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.46 -6.9 -0.39 3.86e-11 Total body bone mineral density; CESC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg12288994 chr5:1860383 NA 0.42 7.1 0.4 1.12e-11 Cardiovascular disease risk factors; CESC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg27170947 chr2:26402098 FAM59B -0.87 -9.83 -0.52 1.2e-19 Gut microbiome composition (summer); CESC cis rs1499614 1.000 rs1882655 chr7:66147057 T/C cg18252515 chr7:66147081 NA 1.42 14.47 0.66 2.33e-35 Gout; CESC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg16405210 chr4:1374714 KIAA1530 -0.98 -13.46 -0.64 7.93e-32 Longevity; CESC cis rs3806843 0.966 rs6579965 chr5:140168811 T/G cg26395211 chr5:140044315 WDR55 -0.42 -5.43 -0.32 1.26e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6582630 0.593 rs11182590 chr12:38574274 A/T cg26384229 chr12:38710491 ALG10B 0.52 7.36 0.41 2.25e-12 Drug-induced liver injury (flucloxacillin); CESC cis rs7937682 0.562 rs527847 chr11:111369132 A/C cg22437258 chr11:111473054 SIK2 -0.47 -5.97 -0.34 7.65e-9 Primary sclerosing cholangitis; CESC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg01988459 chr11:68622903 NA -0.4 -5.5 -0.32 8.8e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs75804782 0.641 rs3769124 chr2:239349362 G/A cg18131467 chr2:239335373 ASB1 -0.66 -5.83 -0.34 1.58e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs3820068 0.603 rs7536654 chr1:15989141 C/G cg13390004 chr1:15929781 NA 0.31 5.17 0.3 4.66e-7 Systolic blood pressure; CESC cis rs17826219 0.568 rs7213925 chr17:29121634 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Body mass index; CESC cis rs11711311 1.000 rs7633832 chr3:113472292 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.06 0.53 2.24e-20 IgG glycosylation; CESC cis rs2635047 0.967 rs3816125 chr18:44601611 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.56 -6.97 -0.39 2.49e-11 Educational attainment; CESC trans rs61931739 0.500 rs11053248 chr12:34518011 G/A cg13010199 chr12:38710504 ALG10B 0.5 6.42 0.37 6.3e-10 Morning vs. evening chronotype; CESC cis rs8067545 0.611 rs1992561 chr17:20219119 G/A cg13482628 chr17:19912719 NA -0.39 -5.06 -0.3 8.02e-7 Schizophrenia; CESC cis rs929354 0.772 rs6459738 chr7:156998532 T/G cg05182265 chr7:156933206 UBE3C -0.51 -7.47 -0.42 1.2e-12 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24034568 chr3:184080707 CLCN2;POLR2H 0.67 7.74 0.43 2.08e-13 Gut microbiome composition (summer); CESC cis rs2115630 0.846 rs8024538 chr15:85368419 A/T cg11189052 chr15:85197271 WDR73 -0.43 -5.65 -0.33 4.2e-8 P wave terminal force; CESC cis rs116095464 0.558 rs9688045 chr5:254035 T/C cg22496380 chr5:211416 CCDC127 -0.73 -8.39 -0.46 2.99e-15 Breast cancer; CESC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.11e-8 Alzheimer's disease; CESC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.55 0.37 2.91e-10 Prudent dietary pattern; CESC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg25767906 chr1:53392781 SCP2 -0.54 -7.48 -0.42 1.08e-12 Monocyte count; CESC cis rs9796 0.621 rs2918462 chr15:41481254 A/G cg20272979 chr15:41787780 ITPKA -0.34 -5.15 -0.3 4.97e-7 Menopause (age at onset); CESC cis rs7107174 1.000 rs2510050 chr11:77982564 A/G cg02023728 chr11:77925099 USP35 0.47 6.49 0.37 4.19e-10 Testicular germ cell tumor; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09164920 chr16:4526354 HMOX2;NMRAL1 -0.55 -7.35 -0.41 2.44e-12 Asthma; CESC trans rs6089829 0.851 rs4809460 chr20:61661355 T/C cg23505145 chr19:12996616 KLF1 0.52 6.7 0.38 1.24e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs2797160 1.000 rs1739380 chr6:126012858 T/C cg05901451 chr6:126070800 HEY2 0.46 6.56 0.37 2.81e-10 Endometrial cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09333812 chr10:99052472 ARHGAP19 -0.48 -6.62 -0.38 1.97e-10 Gut microbiota (bacterial taxa); CESC cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg05347473 chr6:146136440 FBXO30 0.57 7.3 0.41 3.36e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg10691866 chr7:65817282 TPST1 -0.32 -5.45 -0.32 1.15e-7 Aortic root size; CESC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg18446336 chr7:2847575 GNA12 -0.38 -5.75 -0.33 2.51e-8 Height; CESC cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg06577658 chr19:46296270 DMWD 0.42 5.09 0.3 6.69e-7 Coronary artery disease; CESC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg18758796 chr5:131593413 PDLIM4 -0.46 -6.58 -0.37 2.56e-10 Breast cancer; CESC cis rs10733682 0.715 rs3814119 chr9:129462901 A/G cg00232160 chr9:129468157 NA 0.38 6.12 0.35 3.4e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10465746 0.935 rs12410617 chr1:84379461 G/C cg10977910 chr1:84465055 TTLL7 0.47 6.37 0.36 8.21e-10 Obesity-related traits; CESC cis rs4595586 1.000 rs4595586 chr12:39225991 A/T cg26384229 chr12:38710491 ALG10B -0.4 -5.61 -0.33 5.12e-8 Morning vs. evening chronotype; CESC cis rs9311474 0.713 rs352165 chr3:52242902 A/G cg05564831 chr3:52568323 NT5DC2 0.39 6.09 0.35 3.89e-9 Electroencephalogram traits; CESC cis rs7103648 0.643 rs12365079 chr11:47696596 A/T cg10504702 chr11:47789108 FNBP4 0.44 5.52 0.32 8.2e-8 Diastolic blood pressure;Systolic blood pressure; CESC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg11890956 chr21:40555474 PSMG1 1.2 22.3 0.81 9.49e-63 Cognitive function; CESC cis rs798766 0.723 rs3134865 chr4:1723279 T/C cg05874882 chr4:1763078 NA -0.6 -8.45 -0.46 1.98e-15 Bladder cancer;Urinary bladder cancer; CESC cis rs79349575 0.783 rs17708633 chr17:47011620 C/G cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg11764359 chr7:65958608 NA -0.73 -9.8 -0.52 1.49e-19 Aortic root size; CESC trans rs801193 0.591 rs9986881 chr7:66173040 A/G cg26939375 chr7:64535504 NA 0.49 6.47 0.37 4.67e-10 Aortic root size; CESC cis rs56775891 1.000 rs4799088 chr18:77573548 A/G cg13263691 chr18:77568018 NA 0.46 6.82 0.39 6.12e-11 Schizophrenia; CESC cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg11663144 chr21:46675770 NA -0.52 -7.66 -0.43 3.51e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs595018 0.505 rs11230501 chr11:60598075 G/A cg07268726 chr11:60701918 TMEM132A -0.5 -5.66 -0.33 3.9e-8 Wegener's granulomatosis; CESC cis rs12472274 0.646 rs2305171 chr2:239097140 G/A cg17459225 chr2:239074497 NA 0.5 5.89 0.34 1.17e-8 Phospholipid levels (plasma); CESC cis rs7635838 0.620 rs1666988 chr3:11284950 A/G cg00170343 chr3:11313890 ATG7 0.51 7.08 0.4 1.26e-11 HDL cholesterol; CESC cis rs3812762 0.833 rs35670750 chr11:8782444 T/C cg03980550 chr11:8754370 ST5 -0.41 -5.58 -0.32 5.95e-8 Hypospadias; CESC cis rs36051895 0.623 rs4358852 chr9:5251238 C/T cg02405213 chr9:5042618 JAK2 -0.53 -6.45 -0.37 5.36e-10 Pediatric autoimmune diseases; CESC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg11890956 chr21:40555474 PSMG1 -0.67 -9.24 -0.49 8.2e-18 Menarche (age at onset); CESC cis rs115056730 0.520 rs113247402 chr2:98168573 T/C cg26665480 chr2:98280029 ACTR1B -0.93 -6.48 -0.37 4.37e-10 Monocyte chemoattractant protein-3 levels; CESC cis rs6570726 0.643 rs9403735 chr6:145936591 C/T cg23711669 chr6:146136114 FBXO30 0.97 14.71 0.67 3.19e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs7786877 0.626 rs11983745 chr7:100223678 T/C cg16850897 chr7:100343110 ZAN -0.62 -6.62 -0.38 1.99e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg19257562 chr1:2043853 PRKCZ 0.35 5.75 0.33 2.43e-8 Height; CESC cis rs2777491 1.000 rs7167729 chr15:41721042 G/A cg20272979 chr15:41787780 ITPKA 0.45 6.68 0.38 1.39e-10 Ulcerative colitis; CESC cis rs3806843 0.676 rs778593 chr5:140027216 T/C cg16179182 chr5:140090404 VTRNA1-1 0.44 5.61 0.33 5.07e-8 Depressive symptoms (multi-trait analysis); CESC cis rs5769765 0.908 rs138889 chr22:50226673 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.46 -5.19 -0.3 4.28e-7 Schizophrenia; CESC cis rs2769264 0.505 rs11801791 chr1:151387508 C/T cg18801370 chr1:151430492 POGZ 0.55 6.9 0.39 3.88e-11 Blood trace element (Cu levels); CESC cis rs989978 0.532 rs10883364 chr10:101287586 A/G cg09788492 chr10:101292477 NKX2-3 0.31 5.03 0.3 8.88e-7 Red blood cell count; CESC cis rs55788414 0.932 rs12103403 chr16:81185904 C/A cg06400318 chr16:81190750 PKD1L2 -0.57 -6.54 -0.37 3.21e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs830124 0.571 rs1667586 chr12:122382179 A/G cg22168489 chr12:122356033 WDR66 -0.39 -5.14 -0.3 5.32e-7 Urinary metabolites; CESC cis rs7301826 1.000 rs1106369 chr12:131300095 G/T cg11011512 chr12:131303247 STX2 0.41 5.22 0.31 3.53e-7 Plasma plasminogen activator levels; CESC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs1707322 1.000 rs4660896 chr1:46372416 A/G cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10876993 0.893 rs1678504 chr12:58085498 G/C cg18357645 chr12:58087776 OS9 0.65 10.98 0.56 2.31e-23 Celiac disease or Rheumatoid arthritis; CESC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Parkinson's disease; CESC cis rs117623576 0.941 rs17230152 chr10:32431969 A/G cg03047570 chr10:32398778 NA -0.61 -5.56 -0.32 6.59e-8 Anti-saccade response; CESC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.93 0.34 9.38e-9 Bipolar disorder; CESC cis rs854765 0.583 rs7503334 chr17:17779458 C/T cg16928487 chr17:17741425 SREBF1 0.61 10.65 0.55 2.81e-22 Total body bone mineral density; CESC cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg10057126 chr4:77819792 ANKRD56 0.46 6.44 0.37 5.58e-10 Emphysema distribution in smoking; CESC cis rs4073582 0.595 rs3016319 chr11:65981846 C/T cg14036092 chr11:66035641 RAB1B 0.55 7.59 0.42 5.59e-13 Gout; CESC cis rs11055008 0.620 rs2111941 chr12:12829404 A/T cg04607235 chr12:12878440 APOLD1 0.5 6.58 0.37 2.5e-10 Pulse pressure; CESC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg04511125 chr2:88470314 THNSL2 -0.71 -10.38 -0.54 2.19e-21 Response to metformin (IC50); CESC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg21984481 chr17:79567631 NPLOC4 -0.49 -8.04 -0.44 2.97e-14 Eye color traits; CESC trans rs877282 0.898 rs11253349 chr10:765897 C/G cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs2204008 0.665 rs11495668 chr12:38221018 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.65 0.38 1.69e-10 Bladder cancer; CESC cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.62 7.54 0.42 7.41e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs1185460 0.967 rs1786141 chr11:118938315 C/T cg01677386 chr11:118938358 VPS11 -0.47 -6.03 -0.35 5.54e-9 Coronary artery disease; CESC cis rs595982 0.517 rs10404905 chr19:49406175 A/T cg21252483 chr19:49399788 TULP2 0.35 5.18 0.3 4.47e-7 Red cell distribution width; CESC cis rs6842047 1.000 rs9995366 chr4:187131384 T/C cg23442198 chr4:187126114 CYP4V2 0.57 5.07 0.3 7.49e-7 Blood protein levels; CESC cis rs7927592 0.871 rs871212 chr11:68348695 T/A cg16797656 chr11:68205561 LRP5 0.39 5.36 0.31 1.82e-7 Total body bone mineral density; CESC cis rs7726839 0.526 rs55647623 chr5:567747 T/C cg09021430 chr5:549028 NA -0.47 -6.34 -0.36 9.81e-10 Obesity-related traits; CESC cis rs36051895 0.589 rs6476947 chr9:5204279 A/G cg02405213 chr9:5042618 JAK2 -0.49 -5.69 -0.33 3.41e-8 Pediatric autoimmune diseases; CESC cis rs977987 0.835 rs3851734 chr16:75371920 T/C cg03315344 chr16:75512273 CHST6 0.4 5.64 0.33 4.32e-8 Dupuytren's disease; CESC cis rs950027 0.549 rs9920634 chr15:45596546 G/T cg21132104 chr15:45694354 SPATA5L1 -0.58 -6.96 -0.39 2.61e-11 Response to fenofibrate (adiponectin levels); CESC cis rs2742234 0.590 rs2435339 chr10:43642173 G/C cg07801480 chr10:43725741 RASGEF1A 0.42 5.31 0.31 2.34e-7 Hirschsprung disease; CESC cis rs45535039 1.000 rs4938643 chr11:119119045 C/T cg16724696 chr11:118992527 HINFP 0.43 5.29 0.31 2.61e-7 Plateletcrit; CESC cis rs11078917 1 rs11078917 chr17:37746359 A/C cg15445000 chr17:37608096 MED1 0.34 5.18 0.3 4.33e-7 Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06832064 chr1:150551018 MCL1 -0.46 -6.59 -0.38 2.36e-10 Gambling; CESC cis rs7833986 0.501 rs2719227 chr8:57043794 A/G cg26371346 chr8:56986568 SNORD54;RPS20 -0.56 -5.14 -0.3 5.46e-7 Height; CESC cis rs13720 0.673 rs163802 chr20:57578852 C/G cg23907860 chr20:57583709 CTSZ -0.47 -5.79 -0.34 1.98e-8 Platelet distribution width; CESC cis rs9457247 0.967 rs377753 chr6:167389496 A/T cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC cis rs644799 0.562 rs1313288 chr11:95520695 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.61 8.27 0.45 6.69e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg22920501 chr2:26401640 FAM59B -0.9 -10.16 -0.53 1.09e-20 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg22823121 chr1:150693482 HORMAD1 0.48 7.07 0.4 1.36e-11 Tonsillectomy; CESC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg16145915 chr7:1198662 ZFAND2A -0.49 -6.15 -0.35 2.92e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs963731 0.649 rs297137 chr2:39305721 T/C cg04010122 chr2:39346883 SOS1 -0.76 -5.74 -0.33 2.65e-8 Corticobasal degeneration; CESC cis rs5753618 0.555 rs5749286 chr22:31900359 G/T cg02404636 chr22:31891804 SFI1 0.42 5.73 0.33 2.75e-8 Colorectal cancer; CESC cis rs17293817 0.589 rs115985668 chr10:1419403 G/A cg04271617 chr10:1416546 ADARB2 0.36 5.73 0.33 2.68e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9611565 0.592 rs5751101 chr22:41828111 C/T cg03806693 chr22:41940476 POLR3H 1.2 14.31 0.66 8.32e-35 Vitiligo; CESC cis rs7851660 0.679 rs4297160 chr9:100585506 G/A cg13688889 chr9:100608707 NA -0.61 -9.31 -0.5 4.99e-18 Strep throat; CESC cis rs854765 0.547 rs2955377 chr17:17932818 G/A cg16928487 chr17:17741425 SREBF1 -0.53 -8.99 -0.48 4.71e-17 Total body bone mineral density; CESC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg27125505 chr17:43679177 LOC644172 -0.48 -6.62 -0.38 2.01e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs5769765 0.862 rs138857 chr22:50199589 C/T cg02269571 chr22:50332266 NA -0.46 -5.72 -0.33 2.9e-8 Schizophrenia; CESC cis rs9487051 0.597 rs351718 chr6:109552918 G/A cg01475377 chr6:109611718 NA -0.4 -5.35 -0.31 1.92e-7 Reticulocyte fraction of red cells; CESC cis rs7267979 1.000 rs7018 chr20:25278261 A/G cg08601574 chr20:25228251 PYGB 0.38 5.54 0.32 7.26e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.72 9.4 0.5 2.65e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8063761 1.000 rs8063761 chr16:90027626 A/T cg12064134 chr16:90016061 DEF8 0.4 5.31 0.31 2.27e-7 Squamous cell carcinoma; CESC cis rs42648 0.935 rs42668 chr7:89986525 A/C cg23697855 chr7:89950296 NA 0.27 5.12 0.3 5.75e-7 Homocysteine levels; CESC cis rs863345 0.604 rs7518808 chr1:158491820 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC cis rs3892630 0.757 rs8109823 chr19:33183316 A/G cg22980127 chr19:33182716 NUDT19 1.02 11.67 0.58 1.15e-25 Red blood cell traits; CESC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg23048001 chr7:2026167 MAD1L1 0.46 6.05 0.35 4.97e-9 Bipolar disorder and schizophrenia; CESC cis rs4454254 0.901 rs10088129 chr8:141060242 A/G cg06693505 chr8:141057453 TRAPPC9 0.31 5.27 0.31 2.76e-7 Pulse pressure; CESC cis rs72781680 0.898 rs72786298 chr2:24083011 C/T cg08917208 chr2:24149416 ATAD2B 1.13 10.29 0.53 3.99e-21 Lymphocyte counts; CESC cis rs6480314 0.831 rs10733840 chr10:69980221 A/G cg06988349 chr10:69991859 ATOH7 -0.33 -5.23 -0.31 3.38e-7 Optic nerve measurement (disc area); CESC cis rs7520050 0.933 rs6656022 chr1:46394315 A/G cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.66e-9 Red blood cell count;Reticulocyte count; CESC cis rs2731664 0.792 rs335466 chr5:176889530 C/A cg23176889 chr5:176863531 GRK6 -0.64 -11.29 -0.57 2.1e-24 Intelligence (multi-trait analysis); CESC cis rs72781680 0.752 rs7578606 chr2:23902360 T/C cg20701182 chr2:24300061 SF3B14 0.8 6.92 0.39 3.33e-11 Lymphocyte counts; CESC cis rs778371 0.697 rs4973564 chr2:233718440 A/G cg08000102 chr2:233561755 GIGYF2 -0.84 -14.34 -0.66 6.47e-35 Schizophrenia; CESC cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg24110177 chr3:50126178 RBM5 0.58 8.17 0.45 1.28e-14 Body mass index; CESC cis rs1048238 0.846 rs945422 chr1:16345619 T/C cg21214613 chr1:16344536 HSPB7 0.31 5.04 0.3 8.71e-7 Systolic blood pressure; CESC cis rs10927875 0.632 rs10927863 chr1:16165247 C/A cg18973939 chr1:16164122 FLJ37453 0.36 5.46 0.32 1.07e-7 Dilated cardiomyopathy; CESC cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17340548 chr19:46185070 GIPR 0.63 7.53 0.42 7.97e-13 Gut microbiome composition (summer); CESC cis rs12476592 0.602 rs6736029 chr2:63789170 G/A cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs7017914 0.967 rs6993170 chr8:71693519 A/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.44 -5.61 -0.33 4.99e-8 Bone mineral density; CESC trans rs7618501 0.633 rs6446189 chr3:50008566 A/G cg21659725 chr3:3221576 CRBN 0.52 7.18 0.4 7.23e-12 Intelligence (multi-trait analysis); CESC cis rs79349575 0.783 rs12602746 chr17:47031741 A/C cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs9309473 0.500 rs6757996 chr2:73772251 G/A cg20560298 chr2:73613845 ALMS1 -0.52 -7.35 -0.41 2.42e-12 Metabolite levels; CESC cis rs60154123 0.772 rs614167 chr1:210425895 T/C cg22029157 chr1:209979665 IRF6 0.5 5.75 0.33 2.5e-8 Coronary artery disease; CESC cis rs6460942 0.597 rs7808537 chr7:12520913 G/C cg20607287 chr7:12443886 VWDE -0.7 -7.58 -0.42 5.83e-13 Coronary artery disease; CESC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg05552183 chr6:42928497 GNMT -0.75 -12.03 -0.59 7.05e-27 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7258465 1.000 rs7252707 chr19:18612257 G/A cg25828334 chr19:18545568 ISYNA1 -0.35 -5.42 -0.32 1.36e-7 Breast cancer; CESC trans rs7902708 0.920 rs11003015 chr10:54427337 T/G cg26219051 chr22:43739629 SCUBE1 -0.48 -6.19 -0.36 2.25e-9 Bone properties (heel); CESC cis rs2836633 1.000 rs2836634 chr21:40068230 T/A cg05519781 chr21:40033154 ERG 0.59 9.22 0.49 9.41e-18 Coronary artery disease; CESC cis rs7927592 0.763 rs10791982 chr11:68337664 T/G cg20283391 chr11:68216788 NA 0.43 5.36 0.31 1.79e-7 Total body bone mineral density; CESC cis rs2070677 1.000 rs4301745 chr10:135421636 T/G cg20169779 chr10:135381914 SYCE1 -0.74 -9.88 -0.52 8.58e-20 Gout; CESC cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg10523679 chr1:76189770 ACADM 0.68 6.49 0.37 4.14e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg03060546 chr3:49711283 APEH 0.64 7.27 0.41 4.1e-12 Menarche (age at onset); CESC trans rs11098499 0.955 rs35916640 chr4:120155852 T/C cg25214090 chr10:38739885 LOC399744 0.65 8.59 0.47 7.54e-16 Corneal astigmatism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02933375 chr17:78858828 RPTOR 0.53 7.03 0.4 1.77e-11 Fibrinogen levels; CESC cis rs10504229 0.679 rs16921688 chr8:58054659 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -6.75 -0.38 9.05e-11 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15997374 chr11:64666193 ATG2A -0.55 -6.11 -0.35 3.63e-9 Gut microbiome composition (summer); CESC cis rs9549367 0.789 rs2287251 chr13:113889499 A/G cg18105134 chr13:113819100 PROZ -0.65 -7.73 -0.43 2.24e-13 Platelet distribution width; CESC cis rs10129255 0.957 rs10137980 chr14:107183974 G/C cg23076370 chr14:107095027 NA -0.46 -6.01 -0.35 6.16e-9 Kawasaki disease; CESC cis rs7520050 0.807 rs12025621 chr1:46228391 G/A cg06784218 chr1:46089804 CCDC17 -0.31 -5.59 -0.32 5.66e-8 Red blood cell count;Reticulocyte count; CESC cis rs1577917 1.000 rs11759855 chr6:86610841 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -5.91 -0.34 1.05e-8 Response to antipsychotic treatment; CESC cis rs17376456 0.877 rs12109629 chr5:93359702 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.2 0.3 3.98e-7 Diabetic retinopathy; CESC cis rs9894429 0.624 rs9910935 chr17:79613949 T/C cg13777783 chr17:79615861 NA -0.38 -5.91 -0.34 1.05e-8 Eye color traits; CESC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.51 0.42 8.95e-13 Prudent dietary pattern; CESC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.91 10.16 0.53 1.1e-20 Platelet count; CESC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs4523957 0.719 rs1532292 chr17:2097483 T/G cg16513277 chr17:2031491 SMG6 -0.57 -7.84 -0.43 1.08e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9309473 0.847 rs13538 chr2:73868328 A/G cg20560298 chr2:73613845 ALMS1 -0.53 -6.77 -0.38 8.13e-11 Metabolite levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21989094 chr19:39421295 MRPS12;SARS2 -0.46 -6.53 -0.37 3.38e-10 Gambling; CESC trans rs7246657 1.000 rs1823061 chr19:37800626 G/A cg01833234 chr11:6592585 DNHD1 0.54 6.13 0.35 3.19e-9 Coronary artery calcification; CESC cis rs6963495 0.818 rs55740553 chr7:105159551 A/G cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs847577 0.587 rs34307903 chr7:97728449 C/A cg21770322 chr7:97807741 LMTK2 0.83 14.06 0.65 6.11e-34 Breast cancer; CESC cis rs6693567 0.565 rs1776275 chr1:150269437 G/T cg09579323 chr1:150459698 TARS2 -0.47 -6.04 -0.35 5.18e-9 Migraine; CESC cis rs6460942 0.908 rs6948654 chr7:12418546 T/A cg20607287 chr7:12443886 VWDE -0.73 -8.95 -0.48 6.59e-17 Coronary artery disease; CESC cis rs910316 1.000 rs12590452 chr14:75548756 T/C cg08847533 chr14:75593920 NEK9 1.02 20.23 0.78 1.12e-55 Height; CESC cis rs56235845 0.964 rs11741640 chr5:176792743 G/A cg06060754 chr5:176797920 RGS14 0.49 5.14 0.3 5.3e-7 Hemoglobin concentration;Hematocrit; CESC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg21782813 chr7:2030301 MAD1L1 -0.4 -5.62 -0.33 4.71e-8 Bipolar disorder and schizophrenia; CESC cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg22590775 chr19:49891494 CCDC155 0.45 5.04 0.3 8.62e-7 Multiple sclerosis; CESC cis rs7914558 0.966 rs11191518 chr10:104782853 C/G cg15744005 chr10:104629667 AS3MT -0.33 -5.42 -0.32 1.33e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06522697 chr10:121356224 TIAL1 -0.43 -6.04 -0.35 5.27e-9 Fibrinogen levels; CESC cis rs4728302 0.934 rs10258052 chr7:133635874 T/C cg10665199 chr7:133106180 EXOC4 -0.37 -5.04 -0.3 8.52e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg17971929 chr21:40555470 PSMG1 -1.03 -16.37 -0.71 4.3e-42 Cognitive function; CESC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.65 0.38 1.62e-10 Bipolar disorder; CESC cis rs9303401 0.659 rs12600349 chr17:57054245 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.98 -12.11 -0.6 3.72e-27 Cognitive test performance; CESC cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg00149659 chr3:10157352 C3orf10 1.0 11.96 0.59 1.22e-26 Alzheimer's disease; CESC cis rs9915657 0.660 rs2241170 chr17:70070989 G/C cg09344028 chr17:70110421 NA 0.39 7.08 0.4 1.32e-11 Thyroid hormone levels; CESC cis rs6901004 0.803 rs193282 chr6:111543067 G/A cg15721981 chr6:111408429 SLC16A10 -0.35 -5.07 -0.3 7.41e-7 Blood metabolite levels; CESC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg11494091 chr17:61959527 GH2 0.72 12.17 0.6 2.32e-27 Prudent dietary pattern; CESC cis rs4242434 0.927 rs2291232 chr8:22464064 A/G cg03733263 chr8:22462867 KIAA1967 0.93 14.86 0.67 9.8e-37 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs1707322 1.000 rs946524 chr1:46487560 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.6 -0.33 5.27e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs763014 0.898 rs1045277 chr16:633125 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC cis rs9818758 0.607 rs9847839 chr3:49289003 T/C cg00383909 chr3:49044727 WDR6 0.79 6.09 0.35 4e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs4699052 1.000 rs7694190 chr4:104168017 A/G cg16532752 chr4:104119610 CENPE -0.37 -5.04 -0.3 8.58e-7 Testicular germ cell tumor; CESC cis rs8077577 0.689 rs62072543 chr17:18243872 G/A cg16794390 chr17:18148240 FLII 0.41 6.42 0.37 6.22e-10 Obesity-related traits; CESC cis rs7937682 0.883 rs566647 chr11:111466607 A/G cg22437258 chr11:111473054 SIK2 -0.75 -9.18 -0.49 1.27e-17 Primary sclerosing cholangitis; CESC cis rs3820068 0.581 rs72645871 chr1:15926142 G/A cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs73206853 0.544 rs55752061 chr12:111126096 G/C cg12870014 chr12:110450643 ANKRD13A 0.71 5.24 0.31 3.26e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs735396 0.731 rs1182933 chr12:121454622 C/T cg25281562 chr12:121454272 C12orf43 0.52 6.49 0.37 4.18e-10 N-glycan levels; CESC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg27125505 chr17:43679177 LOC644172 -0.5 -6.85 -0.39 5.1e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6500602 0.727 rs4786515 chr16:4578133 T/A cg08645402 chr16:4508243 NA 0.51 8.37 0.46 3.41e-15 Schizophrenia; CESC cis rs7927771 0.864 rs2868459 chr11:47454972 C/G cg05585544 chr11:47624801 NA -0.49 -7.17 -0.4 7.46e-12 Subjective well-being; CESC cis rs314370 0.521 rs314308 chr7:100420878 C/T cg10426581 chr7:100472382 SRRT 0.49 5.44 0.32 1.21e-7 Resting heart rate; CESC cis rs2455799 0.552 rs2470540 chr3:15718652 T/A cg16303742 chr3:15540471 COLQ -0.33 -5.16 -0.3 4.94e-7 Mean platelet volume; CESC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04103315 chr3:42642047 NKTR 0.61 6.57 0.37 2.67e-10 Gut microbiome composition (summer); CESC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg18016565 chr1:150552671 MCL1 0.34 5.07 0.3 7.52e-7 Melanoma; CESC trans rs10411161 0.702 rs10423835 chr19:52387322 A/G cg22319618 chr22:45562946 NUP50 -0.73 -7.14 -0.4 8.9e-12 Breast cancer; CESC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg18305652 chr10:134549665 INPP5A -0.43 -6.0 -0.35 6.52e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs116095464 0.558 rs10043002 chr5:226753 G/A cg20965017 chr5:231967 SDHA -0.45 -5.15 -0.3 5.04e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12435584 chr6:107780425 PDSS2 0.56 6.38 0.36 7.99e-10 Gut microbiome composition (summer); CESC cis rs6580649 0.941 rs12580764 chr12:48453882 G/A cg24011408 chr12:48396354 COL2A1 -0.42 -5.28 -0.31 2.67e-7 Lung cancer; CESC cis rs34779708 0.966 rs35814343 chr10:35427714 G/T cg03585969 chr10:35415529 CREM 0.76 10.09 0.53 1.81e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg25036284 chr2:26402008 FAM59B -0.82 -9.43 -0.5 2.23e-18 Gut microbiome composition (summer); CESC cis rs8114671 0.836 rs6058154 chr20:33585834 C/T cg24642439 chr20:33292090 TP53INP2 -0.51 -6.27 -0.36 1.45e-9 Height; CESC cis rs9815354 1.000 rs17063649 chr3:41863406 C/T cg03022575 chr3:42003672 ULK4 0.49 5.51 0.32 8.46e-8 Pulse pressure;Diastolic blood pressure; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg11522767 chr6:157342961 ARID1B 0.48 6.31 0.36 1.18e-9 Obesity-related traits; CESC cis rs1707322 0.752 rs11211152 chr1:46114157 C/T cg05343316 chr1:45956843 TESK2 0.51 6.24 0.36 1.7e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9640161 0.789 rs13223702 chr7:150058968 G/A cg21361702 chr7:150065534 REPIN1 0.61 6.62 0.38 1.93e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs68170813 0.641 rs1978085 chr7:107095216 T/C cg02696742 chr7:106810147 HBP1 -0.56 -5.26 -0.31 3.03e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01140579 chr3:48541502 SHISA5 0.51 6.2 0.36 2.12e-9 Gut microbiome composition (summer); CESC cis rs6964587 0.967 rs10248102 chr7:91699779 G/A cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.45e-15 Breast cancer; CESC trans rs7824557 0.525 rs12682349 chr8:11245303 C/G cg06636001 chr8:8085503 FLJ10661 0.49 6.18 0.35 2.47e-9 Retinal vascular caliber; CESC cis rs2286503 0.901 rs10950922 chr7:22854006 C/T cg13679077 chr7:22862647 TOMM7 0.4 5.07 0.3 7.52e-7 Fibrinogen; CESC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg04369109 chr6:150039330 LATS1 -0.39 -5.27 -0.31 2.82e-7 Lung cancer; CESC cis rs8060686 0.858 rs7187289 chr16:67967878 A/C cg26727032 chr16:67993705 SLC12A4 -0.64 -9.33 -0.5 4.45e-18 HDL cholesterol;Metabolic syndrome; CESC cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg12756686 chr19:29218302 NA 0.42 5.87 0.34 1.3e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs6963495 0.818 rs73190161 chr7:105156871 C/T cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs7692995 1.000 rs16896074 chr4:17947873 T/C cg08925142 chr4:18023851 LCORL -0.44 -5.1 -0.3 6.36e-7 Height; CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.55 0.32 6.9e-8 Bipolar disorder; CESC cis rs5769765 0.817 rs8142561 chr22:50291750 T/C cg26441486 chr22:50317300 CRELD2 0.39 5.37 0.31 1.76e-7 Schizophrenia; CESC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg16278512 chr7:12443529 VWDE 0.46 5.38 0.31 1.62e-7 Coronary artery disease; CESC cis rs2668423 0.502 rs7254913 chr19:1388320 A/G cg02639931 chr19:1387894 NDUFS7 0.69 15.0 0.68 2.98e-37 Nonalcoholic fatty liver disease; CESC cis rs3820068 0.705 rs951225 chr1:15826292 G/A cg17385448 chr1:15911702 AGMAT 0.39 6.18 0.35 2.44e-9 Systolic blood pressure; CESC cis rs858239 0.600 rs10488077 chr7:23144182 A/T cg23682824 chr7:23144976 KLHL7 0.51 6.8 0.39 7.07e-11 Cerebrospinal fluid biomarker levels; CESC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg12463550 chr7:65579703 CRCP 0.56 7.16 0.4 8.17e-12 Aortic root size; CESC cis rs8014204 0.836 rs8021280 chr14:75290018 C/G cg08847533 chr14:75593920 NEK9 0.47 6.01 0.35 6.18e-9 Caffeine consumption; CESC cis rs7814319 0.646 rs938828 chr8:97316821 A/C cg20787634 chr8:97240163 UQCRB -0.57 -7.28 -0.41 3.75e-12 Lung function (FVC); CESC cis rs7818688 1.000 rs7818688 chr8:96024082 C/A cg16049864 chr8:95962084 TP53INP1 0.61 5.77 0.33 2.17e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg19717773 chr7:2847554 GNA12 -0.56 -7.87 -0.44 8.93e-14 Height; CESC cis rs2046867 0.862 rs6778168 chr3:72840206 T/A cg25664220 chr3:72788482 NA -0.38 -5.69 -0.33 3.42e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.64 0.38 1.79e-10 Bipolar disorder; CESC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg10691866 chr7:65817282 TPST1 -0.36 -5.92 -0.34 9.82e-9 Aortic root size; CESC cis rs3857536 0.776 rs9294687 chr6:66942919 C/T cg07460842 chr6:66804631 NA -0.41 -5.28 -0.31 2.71e-7 Blood trace element (Cu levels); CESC cis rs600231 0.706 rs3782091 chr11:65336483 G/T cg21890820 chr11:65308645 LTBP3 -0.4 -5.1 -0.3 6.4e-7 Bone mineral density; CESC cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg17143192 chr8:8559678 CLDN23 0.67 8.16 0.45 1.4e-14 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09041756 chr7:5570314 ACTB -0.5 -6.84 -0.39 5.55e-11 Fibrinogen levels; CESC cis rs11122272 0.735 rs2486735 chr1:231521778 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs854765 0.583 rs4534911 chr17:17852330 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 7.66 0.43 3.56e-13 Total body bone mineral density; CESC cis rs6484504 0.576 rs2756191 chr11:31135882 A/T cg14844989 chr11:31128820 NA 0.42 6.02 0.35 5.86e-9 Red blood cell count; CESC cis rs9790314 0.521 rs60625846 chr3:161084525 G/T cg04691961 chr3:161091175 C3orf57 -0.37 -5.11 -0.3 6.18e-7 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.51 0.37 3.75e-10 Prudent dietary pattern; CESC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg07936489 chr17:37558343 FBXL20 -0.81 -11.8 -0.59 4.2e-26 Glomerular filtration rate (creatinine); CESC cis rs17401966 0.931 rs10864448 chr1:10277497 A/T cg15208524 chr1:10270712 KIF1B 0.47 6.0 0.35 6.47e-9 Hepatocellular carcinoma; CESC cis rs1395 0.778 rs724311 chr2:27441645 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 5.92 0.34 1.01e-8 Blood metabolite levels; CESC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg17178900 chr1:205818956 PM20D1 0.78 12.92 0.62 5.92e-30 Menarche (age at onset); CESC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg21770322 chr7:97807741 LMTK2 0.57 8.63 0.47 5.93e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs748404 0.660 rs2249952 chr15:43720533 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.55 0.42 7.19e-13 Lung cancer; CESC cis rs10465746 0.967 rs942849 chr1:84427499 G/A cg10977910 chr1:84465055 TTLL7 0.46 6.18 0.35 2.45e-9 Obesity-related traits; CESC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg15052019 chr19:19431593 KIAA0892;SF4 -0.42 -5.39 -0.31 1.53e-7 Tonsillectomy; CESC cis rs832540 0.931 rs832399 chr5:56222358 A/T cg12311346 chr5:56204834 C5orf35 -0.43 -5.38 -0.31 1.66e-7 Coronary artery disease; CESC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg09365446 chr1:150670422 GOLPH3L 0.4 5.6 0.33 5.44e-8 Tonsillectomy; CESC cis rs8103278 1.000 rs8108864 chr19:46301671 G/A cg14061069 chr19:46274453 DMPK -0.37 -5.07 -0.3 7.38e-7 Coronary artery disease; CESC cis rs208520 0.690 rs4710311 chr6:66823223 C/T cg07460842 chr6:66804631 NA -0.86 -11.82 -0.59 3.51e-26 Exhaled nitric oxide output; CESC cis rs11122272 0.735 rs2739515 chr1:231514681 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs34779708 0.931 rs34954932 chr10:35410807 G/T cg03585969 chr10:35415529 CREM 0.77 10.36 0.54 2.41e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs1538970 0.962 rs7532762 chr1:45864695 C/A cg06784218 chr1:46089804 CCDC17 0.31 5.33 0.31 2.13e-7 Platelet count; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15353389 chr12:120525027 CCDC64 0.48 6.59 0.38 2.43e-10 Systemic lupus erythematosus; CESC cis rs6120849 0.754 rs6088686 chr20:33623437 C/T cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC trans rs11098499 0.754 rs7672594 chr4:120248543 A/C cg25214090 chr10:38739885 LOC399744 0.62 8.71 0.47 3.41e-16 Corneal astigmatism; CESC cis rs2262909 0.962 rs73021832 chr19:22316144 G/C cg11619707 chr19:22235551 ZNF257 0.34 5.48 0.32 1e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC trans rs10500991 0.737 rs11602503 chr11:24879440 T/C cg07129253 chr8:30890560 PURG;WRN -0.54 -6.74 -0.38 1.01e-10 Iron status biomarkers; CESC cis rs367615 0.552 rs2416210 chr5:108741137 C/T cg17395555 chr5:108820864 NA -0.45 -7.45 -0.42 1.34e-12 Colorectal cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs681343 1.000 rs681343 chr19:49206462 C/T cg21064579 chr19:49206444 FUT2 0.52 7.39 0.41 1.98e-12 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CESC cis rs9929218 0.953 rs9927329 chr16:68750331 C/T cg02972257 chr16:68554789 NA 0.56 6.46 0.37 4.87e-10 Colorectal cancer; CESC cis rs3096299 0.933 rs2965938 chr16:89491336 C/T cg00750074 chr16:89608354 SPG7 -0.39 -5.62 -0.33 4.73e-8 Multiple myeloma (IgH translocation); CESC cis rs778371 0.624 rs6733495 chr2:233616709 A/G cg08000102 chr2:233561755 GIGYF2 0.83 14.46 0.66 2.52e-35 Schizophrenia; CESC cis rs734999 0.549 rs3828154 chr1:2524943 G/A cg18854424 chr1:2615690 NA 0.28 5.48 0.32 1.01e-7 Ulcerative colitis; CESC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.6 -0.38 2.25e-10 Depression; CESC cis rs2243480 0.803 rs36127118 chr7:65565505 A/G cg12463550 chr7:65579703 CRCP 0.75 5.83 0.34 1.63e-8 Diabetic kidney disease; CESC cis rs12478296 1.000 rs60533128 chr2:243028088 A/G cg06360820 chr2:242988706 NA -1.01 -9.22 -0.49 9.77e-18 Obesity-related traits; CESC cis rs3850699 0.886 rs12773833 chr10:104418350 C/T cg04362960 chr10:104952993 NT5C2 0.45 5.53 0.32 7.68e-8 Prostate cancer; CESC trans rs2321882 0.958 rs6561986 chr13:59393763 C/T cg20914879 chr14:56566808 NA -0.43 -6.17 -0.35 2.51e-9 Body mass index; CESC cis rs4950928 0.774 rs4950931 chr1:203164075 G/A cg14085262 chr1:203155938 CHI3L1 -0.48 -5.3 -0.31 2.43e-7 YKL-40 levels; CESC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg13393036 chr8:95962371 TP53INP1 -0.47 -9.94 -0.52 5.45e-20 Type 2 diabetes; CESC cis rs1348850 0.567 rs3770009 chr2:178536544 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 6.78 0.38 7.63e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs668210 0.793 rs586921 chr11:65747701 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.64 -6.04 -0.35 5.25e-9 Cerebrospinal fluid biomarker levels; CESC cis rs472402 0.540 rs2288445 chr5:6620092 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.5 -6.51 -0.37 3.79e-10 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17367356 chr11:45907078 MAPK8IP1 0.61 6.71 0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg02725872 chr8:58115012 NA -0.42 -5.88 -0.34 1.25e-8 Developmental language disorder (linguistic errors); CESC cis rs1728785 0.688 rs698729 chr16:68624205 G/C cg02972257 chr16:68554789 NA -0.64 -7.22 -0.41 5.58e-12 Ulcerative colitis; CESC cis rs62005083 1.000 rs62006761 chr14:74616299 T/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.74 5.42 0.32 1.34e-7 Mean corpuscular volume; CESC trans rs208520 0.690 rs207094 chr6:66799009 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.82 -0.62 1.32e-29 Exhaled nitric oxide output; CESC cis rs6570726 1.000 rs450076 chr6:145847655 G/T cg23711669 chr6:146136114 FBXO30 0.76 11.25 0.57 2.92e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs11958404 0.615 rs10061079 chr5:157449968 G/C cg05962755 chr5:157440814 NA 0.38 5.65 0.33 4.06e-8 IgG glycosylation; CESC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg24642844 chr7:1081250 C7orf50 -0.74 -8.83 -0.48 1.46e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611519 0.929 rs73174660 chr22:41437304 T/C cg03806693 chr22:41940476 POLR3H -0.56 -5.88 -0.34 1.22e-8 Neuroticism; CESC cis rs4253772 0.591 rs6008384 chr22:46655948 T/C cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.49 5.14 0.3 5.39e-7 LDL cholesterol;Cholesterol, total; CESC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg18904891 chr8:8559673 CLDN23 0.69 8.05 0.44 2.87e-14 Obesity-related traits; CESC cis rs8180040 0.932 rs62246474 chr3:47398130 C/T cg27129171 chr3:47204927 SETD2 -0.68 -10.45 -0.54 1.24e-21 Colorectal cancer; CESC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg25036284 chr2:26402008 FAM59B -0.59 -6.7 -0.38 1.23e-10 Gut microbiome composition (summer); CESC cis rs78456975 0.600 rs72776256 chr2:1529595 C/A cg01028140 chr2:1542097 TPO -0.61 -5.79 -0.33 2.02e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs10267417 0.514 rs2072184 chr7:19748883 A/G cg07541023 chr7:19748670 TWISTNB 0.86 8.92 0.48 7.92e-17 Night sleep phenotypes; CESC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg18876405 chr7:65276391 NA -0.55 -7.4 -0.41 1.75e-12 Aortic root size; CESC cis rs9287719 0.934 rs6721510 chr2:10751046 T/C cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10990685 chr12:120720139 NME2P1 0.53 7.04 0.4 1.65e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg11764359 chr7:65958608 NA -0.93 -15.42 -0.69 1.01e-38 Aortic root size; CESC cis rs62064224 0.720 rs8078837 chr17:30763537 A/G cg25809561 chr17:30822961 MYO1D 0.62 9.08 0.49 2.59e-17 Schizophrenia; CESC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg16145915 chr7:1198662 ZFAND2A -0.57 -8.7 -0.47 3.58e-16 Longevity;Endometriosis; CESC trans rs10411161 0.702 rs6509592 chr19:52393150 G/A cg22319618 chr22:45562946 NUP50 -0.74 -7.34 -0.41 2.7e-12 Breast cancer; CESC cis rs4555082 0.957 rs10140586 chr14:105749582 A/G cg06808227 chr14:105710500 BRF1 -0.53 -6.56 -0.37 2.88e-10 Mean platelet volume;Platelet distribution width; CESC cis rs2439831 0.850 rs8032649 chr15:44134922 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.6 -5.47 -0.32 1.06e-7 Lung cancer in ever smokers; CESC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg13206674 chr6:150067644 NUP43 0.41 5.87 0.34 1.31e-8 Lung cancer; CESC cis rs17021463 0.673 rs17565759 chr4:95280763 C/T cg11021082 chr4:95130006 SMARCAD1 0.5 6.91 0.39 3.66e-11 Testicular germ cell tumor; CESC cis rs4948102 0.642 rs6593297 chr7:56122058 A/T cg09872392 chr7:56161020 PHKG1 0.44 7.21 0.4 5.83e-12 Plasma homocysteine levels (post-methionine load test); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03931927 chr7:65215969 CCT6P1 -0.47 -6.62 -0.38 1.97e-10 Fibrinogen levels; CESC cis rs9487051 0.652 rs13210424 chr6:109598737 G/A cg01475377 chr6:109611718 NA -0.44 -6.88 -0.39 4.24e-11 Reticulocyte fraction of red cells; CESC cis rs2806561 0.514 rs7519093 chr1:23541078 A/T cg19743168 chr1:23544995 NA -0.37 -5.76 -0.33 2.32e-8 Height; CESC cis rs7586879 0.639 rs6749170 chr2:25110962 A/G cg01884057 chr2:25150051 NA 0.37 7.13 0.4 9.47e-12 Body mass index; CESC trans rs2018683 0.624 rs2286220 chr7:28998699 G/C cg19402173 chr7:128379420 CALU -0.58 -7.07 -0.4 1.36e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs10242455 0.702 rs73405247 chr7:99159174 C/G cg25640893 chr7:99214727 ZNF498 0.78 5.5 0.32 8.75e-8 Blood metabolite levels; CESC cis rs60154123 0.505 rs115881613 chr1:210040369 C/T cg22029157 chr1:209979665 IRF6 0.72 7.16 0.4 8.04e-12 Coronary artery disease; CESC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg00149659 chr3:10157352 C3orf10 -0.61 -7.54 -0.42 7.57e-13 Alzheimer's disease; CESC cis rs8018808 0.935 rs1061629 chr14:77926011 A/G cg20045696 chr14:77926864 AHSA1 -0.41 -5.44 -0.32 1.23e-7 Myeloid white cell count; CESC cis rs6752107 1.000 rs2241879 chr2:234183468 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.7 0.38 1.25e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs9733 0.744 rs2039590 chr1:150813315 G/A cg13175981 chr1:150552382 MCL1 0.49 6.75 0.38 9.09e-11 Tonsillectomy; CESC cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg03060546 chr3:49711283 APEH 0.45 5.5 0.32 9e-8 Parkinson's disease; CESC cis rs2425143 1.000 rs17093027 chr20:34319118 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.49 -0.42 1.03e-12 Blood protein levels; CESC cis rs1728785 1.000 rs698719 chr16:68560125 C/T cg02972257 chr16:68554789 NA -0.56 -6.46 -0.37 5.11e-10 Ulcerative colitis; CESC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg09359103 chr1:154839909 KCNN3 -0.64 -11.52 -0.58 3.75e-25 Prostate cancer; CESC cis rs1034435 0.755 rs5768679 chr22:48892847 T/G cg05992904 chr22:48892994 FAM19A5 -0.57 -9.8 -0.52 1.53e-19 Late-onset Alzheimer's disease; CESC trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg03929089 chr4:120376271 NA 0.75 8.78 0.47 2.11e-16 Height; CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg12963246 chr6:28129442 ZNF389 0.59 8.01 0.44 3.74e-14 Depression; CESC cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7216064 0.906 rs1976052 chr17:65830578 C/T cg07042672 chr17:66097459 LOC651250 -0.5 -5.06 -0.3 7.79e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.44 5.53 0.32 7.7e-8 Tonsillectomy; CESC cis rs763014 0.931 rs7191939 chr16:630089 C/T cg09263875 chr16:632152 PIGQ 0.66 10.93 0.56 3.24e-23 Height; CESC trans rs17764205 0.929 rs10421936 chr19:3256484 C/T cg27384338 chr17:2031545 SMG6 -0.64 -6.08 -0.35 4.2e-9 Bipolar disorder and schizophrenia; CESC cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 12.78 0.62 1.82e-29 Personality dimensions; CESC cis rs12348691 0.503 rs1348386 chr9:100612807 A/G cg13688889 chr9:100608707 NA -0.9 -13.36 -0.63 1.76e-31 Alopecia areata; CESC cis rs7246657 0.943 rs1559229 chr19:37876197 T/C cg23950597 chr19:37808831 NA -0.55 -6.06 -0.35 4.78e-9 Coronary artery calcification; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19980912 chr5:133304180 C5orf15 -0.45 -6.25 -0.36 1.65e-9 Fibrinogen levels; CESC cis rs4319547 0.774 rs7954006 chr12:123131824 A/C cg05707623 chr12:122985044 ZCCHC8 0.48 5.76 0.33 2.35e-8 Body mass index; CESC cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg02187348 chr16:89574699 SPG7 -0.58 -8.11 -0.45 1.9e-14 Multiple myeloma (IgH translocation); CESC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg25517755 chr10:38738941 LOC399744 -0.49 -6.35 -0.36 9.09e-10 Extrinsic epigenetic age acceleration; CESC trans rs3780486 0.846 rs6476399 chr9:33123013 A/G cg20290983 chr6:43655470 MRPS18A 0.98 18.34 0.75 4.45e-49 IgG glycosylation; CESC cis rs4595586 0.505 rs76485055 chr12:39358294 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC cis rs753778 0.667 rs6578153 chr8:142209543 C/T cg23750338 chr8:142222470 SLC45A4 0.38 5.55 0.32 6.98e-8 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs11608355 0.515 rs11609921 chr12:109918405 A/G cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs2236918 1.000 rs735943 chr1:242030151 C/T cg17736920 chr1:242011382 EXO1 -0.66 -8.95 -0.48 6.54e-17 Menopause (age at onset); CESC cis rs13064411 0.696 rs6438161 chr3:113227637 G/A cg18753928 chr3:113234510 CCDC52 -0.5 -6.13 -0.35 3.23e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs6831352 0.851 rs1230164 chr4:99986023 C/G cg13256891 chr4:100009986 ADH5 0.63 6.75 0.38 9.24e-11 Alcohol dependence; CESC cis rs11122272 0.735 rs2790884 chr1:231531932 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs34779708 0.966 rs12762493 chr10:35471873 G/A cg04310649 chr10:35416472 CREM -0.54 -6.54 -0.37 3.16e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs17407555 0.601 rs73229828 chr4:10026833 A/G cg00071950 chr4:10020882 SLC2A9 -0.58 -5.86 -0.34 1.36e-8 Schizophrenia (age at onset); CESC cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg20891283 chr12:69753455 YEATS4 0.6 8.51 0.46 1.3e-15 Blood protein levels; CESC cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg13628971 chr7:2884303 GNA12 0.42 5.54 0.32 7.32e-8 Height; CESC cis rs2273669 0.667 rs111523655 chr6:109301664 G/A cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC cis rs28829049 0.570 rs12060125 chr1:19391108 A/G cg13387374 chr1:19411106 UBR4 -0.42 -5.54 -0.32 7.27e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs9911578 1.000 rs12453049 chr17:56611372 C/T cg12560992 chr17:57184187 TRIM37 -0.93 -15.59 -0.69 2.43e-39 Intelligence (multi-trait analysis); CESC cis rs7727544 0.735 rs272879 chr5:131670546 C/G cg07395648 chr5:131743802 NA -0.46 -6.06 -0.35 4.78e-9 Blood metabolite levels; CESC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg18230493 chr5:56204884 C5orf35 -0.74 -8.84 -0.48 1.37e-16 Initial pursuit acceleration; CESC trans rs561341 1.000 rs506766 chr17:30289659 T/C cg27661571 chr11:113659931 NA -0.8 -6.98 -0.39 2.37e-11 Hip circumference adjusted for BMI; CESC cis rs7264396 0.790 rs6058294 chr20:34259396 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.66 7.92 0.44 6.7e-14 Total cholesterol levels; CESC cis rs11785400 1.000 rs11785400 chr8:143730456 C/T cg10596483 chr8:143751796 JRK 0.41 5.41 0.32 1.43e-7 Schizophrenia; CESC trans rs7726839 0.540 rs72705030 chr5:645562 C/T cg25482853 chr8:67687455 SGK3 1.01 10.42 0.54 1.61e-21 Obesity-related traits; CESC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.84 0.59 2.99e-26 Alzheimer's disease; CESC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg23803603 chr1:2058230 PRKCZ -0.35 -6.16 -0.35 2.74e-9 Height; CESC cis rs4330281 0.702 rs10433561 chr3:17803996 T/G cg20981856 chr3:17787350 NA 0.38 5.35 0.31 1.87e-7 Schizophrenia; CESC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Parkinson's disease; CESC cis rs9926296 0.572 rs8046872 chr16:89841552 T/C cg04287289 chr16:89883240 FANCA 0.59 7.91 0.44 7.09e-14 Vitiligo; CESC cis rs12142240 0.659 rs17361873 chr1:46832686 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.08 0.44 2.37e-14 Menopause (age at onset); CESC cis rs7312933 1.000 rs11181328 chr12:42504679 T/G cg01256987 chr12:42539512 GXYLT1 -0.34 -5.13 -0.3 5.66e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7296418 0.699 rs11057219 chr12:123750073 T/C cg05973401 chr12:123451056 ABCB9 0.46 5.93 0.34 9.46e-9 Platelet count; CESC cis rs9486719 1.000 rs72931061 chr6:96880285 G/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.84 0.34 1.55e-8 Tonsillectomy; CESC cis rs7592578 0.664 rs10931461 chr2:191405280 T/A cg10560079 chr2:191398806 TMEM194B 0.66 5.89 0.34 1.14e-8 Diastolic blood pressure; CESC cis rs9388451 0.772 rs1268064 chr6:126042578 G/A cg05901451 chr6:126070800 HEY2 0.6 8.58 0.47 8.27e-16 Brugada syndrome; CESC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg23754390 chr11:835074 CD151 0.31 5.28 0.31 2.75e-7 Mean platelet volume; CESC cis rs7084402 1.000 rs28426375 chr10:60285478 T/A cg07615347 chr10:60278583 BICC1 0.61 9.7 0.51 3.12e-19 Refractive error; CESC cis rs17384381 0.953 rs12717763 chr1:85808164 A/T cg16011679 chr1:85725395 C1orf52 0.81 8.44 0.46 2.12e-15 Lobe attachment (rater-scored or self-reported); CESC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg01411255 chr17:61851458 DDX42;CCDC47 1.06 16.15 0.7 2.57e-41 Height; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg09474081 chr11:94501387 AMOTL1 -0.42 -6.3 -0.36 1.21e-9 Breast cancer; CESC cis rs4704187 0.687 rs4389672 chr5:74368642 G/T cg03227963 chr5:74354835 NA 0.31 5.79 0.34 1.99e-8 Response to amphetamines; CESC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg21251018 chr6:28226885 NKAPL 0.35 5.63 0.33 4.61e-8 Cardiac Troponin-T levels; CESC cis rs801193 0.548 rs2659904 chr7:66178602 C/A cg11764359 chr7:65958608 NA 0.87 13.23 0.63 4.93e-31 Aortic root size; CESC cis rs11190604 1.000 rs35106985 chr10:102307542 T/C cg07080220 chr10:102295463 HIF1AN 0.63 6.0 0.35 6.54e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs2204008 0.805 rs11169513 chr12:37988640 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.83 0.55 6.91e-23 Bladder cancer; CESC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.49e-7 Life satisfaction; CESC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg07936489 chr17:37558343 FBXL20 0.77 10.94 0.56 3.02e-23 Glomerular filtration rate (creatinine); CESC cis rs9388451 0.874 rs13209968 chr6:126089285 G/C cg10911889 chr6:126070802 HEY2 0.39 5.31 0.31 2.3e-7 Brugada syndrome; CESC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg06456125 chr7:65229604 NA 0.44 5.73 0.33 2.7e-8 Aortic root size; CESC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.6 0.33 5.36e-8 Menopause (age at onset); CESC cis rs7937682 0.889 rs12360825 chr11:111528786 A/T cg09085632 chr11:111637200 PPP2R1B -0.97 -15.5 -0.69 5.25e-39 Primary sclerosing cholangitis; CESC cis rs3733585 0.563 rs881971 chr4:9930962 A/G cg11266682 chr4:10021025 SLC2A9 -0.52 -9.6 -0.51 6.34e-19 Cleft plate (environmental tobacco smoke interaction); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg05515957 chr12:14956570 WBP11;C12orf60 -0.42 -6.46 -0.37 5.12e-10 Vertical cup-disc ratio; CESC cis rs8040855 0.627 rs11632175 chr15:85611680 T/A cg08123816 chr15:85640762 PDE8A -0.41 -6.08 -0.35 4.18e-9 Bulimia nervosa; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24132523 chr1:145827062 GPR89A -0.47 -6.53 -0.37 3.42e-10 Gut microbiota (bacterial taxa); CESC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg05564831 chr3:52568323 NT5DC2 0.45 6.96 0.39 2.68e-11 Bipolar disorder; CESC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg12311346 chr5:56204834 C5orf35 -0.81 -9.5 -0.5 1.33e-18 Initial pursuit acceleration; CESC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg01416388 chr22:39784598 NA -0.58 -7.11 -0.4 1.1e-11 Intelligence (multi-trait analysis); CESC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 10.22 0.53 6.88e-21 Platelet count; CESC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -6.43 -0.37 5.82e-10 Parkinson's disease; CESC cis rs2072732 0.861 rs3795262 chr1:2938697 A/C cg15211996 chr1:2936768 ACTRT2 0.33 5.46 0.32 1.1e-7 Plateletcrit; CESC cis rs11676348 0.755 rs1008562 chr2:219026972 G/C cg20019365 chr2:219134978 PNKD;AAMP 0.43 5.52 0.32 7.92e-8 Ulcerative colitis; CESC cis rs2070488 0.965 rs2051215 chr3:38560345 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.9 -16.74 -0.72 2.14e-43 Electrocardiographic conduction measures; CESC cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg03467027 chr4:99064603 C4orf37 0.49 6.16 0.35 2.65e-9 Colonoscopy-negative controls vs population controls; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15604170 chr13:19203463 NA -0.42 -6.47 -0.37 4.7e-10 Asthma; CESC cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.69 6.68 0.38 1.41e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg04287289 chr16:89883240 FANCA 0.9 15.3 0.68 2.55e-38 Vitiligo; CESC cis rs7772486 0.875 rs2748501 chr6:146312258 G/A cg23711669 chr6:146136114 FBXO30 0.9 13.01 0.62 3.07e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs11122272 0.735 rs973252 chr1:231520802 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs8018808 1.000 rs4903577 chr14:77847258 C/T cg20045696 chr14:77926864 AHSA1 -0.4 -5.37 -0.31 1.68e-7 Myeloid white cell count; CESC cis rs7216064 0.953 rs8073510 chr17:65839210 A/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.83 -0.48 1.49e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11122272 0.735 rs2808585 chr1:231514218 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg05564831 chr3:52568323 NT5DC2 -0.38 -5.32 -0.31 2.19e-7 Bipolar disorder; CESC cis rs6121246 0.567 rs2889488 chr20:30185758 G/A cg13852791 chr20:30311386 BCL2L1 0.67 6.71 0.38 1.2e-10 Mean corpuscular hemoglobin; CESC cis rs11098499 0.863 rs3775858 chr4:120486028 A/G cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.27e-28 Corneal astigmatism; CESC cis rs2249694 0.586 rs9418987 chr10:135324409 A/G cg20169779 chr10:135381914 SYCE1 0.4 5.29 0.31 2.52e-7 Obesity-related traits; CESC cis rs6032067 0.852 rs17333180 chr20:43803708 C/A cg10761708 chr20:43804764 PI3 0.55 6.55 0.37 2.91e-10 Blood protein levels; CESC cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs13191362 0.507 rs2846519 chr6:163045463 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.47 -5.87 -0.34 1.28e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4268898 0.722 rs12185638 chr2:24382030 C/G cg06627628 chr2:24431161 ITSN2 0.52 6.77 0.38 8.5e-11 Asthma; CESC cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg11644478 chr21:40555479 PSMG1 0.99 15.29 0.68 2.91e-38 Cognitive function; CESC cis rs155076 0.938 rs485361 chr13:21845826 G/T cg11317459 chr13:21872234 NA -1.01 -11.12 -0.56 7.88e-24 White matter hyperintensity burden; CESC cis rs10870270 1.000 rs10870292 chr10:133770782 G/C cg08754478 chr10:133766260 PPP2R2D -0.58 -7.52 -0.42 8.66e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs6963495 0.818 rs818621 chr7:105173029 T/C cg02135003 chr7:105160482 PUS7 -0.44 -5.98 -0.34 7.1e-9 Bipolar disorder (body mass index interaction); CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg07507251 chr3:52567010 NT5DC2 0.38 7.27 0.41 3.99e-12 Bipolar disorder; CESC cis rs17818399 0.926 rs13032670 chr2:46830794 C/T cg02822958 chr2:46747628 ATP6V1E2 0.47 5.64 0.33 4.45e-8 Height; CESC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg13607699 chr17:42295918 UBTF -0.57 -7.31 -0.41 3.2e-12 Total body bone mineral density; CESC cis rs3617 0.573 rs9810807 chr3:52924227 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.31 -5.26 -0.31 3.03e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs11250464 0.833 rs4554799 chr10:1407728 C/T cg08668359 chr10:1443807 ADARB2 0.6 7.32 0.41 2.89e-12 Radiation response; CESC cis rs7903847 0.642 rs11814021 chr10:99158386 A/G cg20016023 chr10:99160130 RRP12 -0.3 -5.17 -0.3 4.63e-7 Granulocyte percentage of myeloid white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10735211 chr4:4310922 ZNF509 -0.59 -7.13 -0.4 9.8e-12 Gut microbiome composition (summer); CESC cis rs9291683 0.546 rs13110307 chr4:10044364 T/C cg02734326 chr4:10020555 SLC2A9 0.45 6.19 0.36 2.29e-9 Bone mineral density; CESC cis rs6714710 0.603 rs7421146 chr2:98552271 G/C cg26665480 chr2:98280029 ACTR1B 0.67 8.99 0.48 4.92e-17 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs3809566 0.637 rs8026047 chr15:63323347 C/G cg12160578 chr15:63334699 TPM1 0.45 5.52 0.32 8.13e-8 Platelet count; CESC cis rs7659604 0.592 rs56077950 chr4:122721412 C/T cg06713675 chr4:122721982 EXOSC9 -0.51 -7.04 -0.4 1.65e-11 Type 2 diabetes; CESC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg12311346 chr5:56204834 C5orf35 -0.47 -5.73 -0.33 2.67e-8 Coronary artery disease; CESC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg06494592 chr3:125709126 NA -0.51 -5.44 -0.32 1.22e-7 Blood pressure (smoking interaction); CESC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg00166722 chr3:10149974 C3orf24 0.46 5.89 0.34 1.18e-8 Alzheimer's disease; CESC cis rs854765 0.583 rs4077198 chr17:17834563 T/C cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.9e-9 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02574861 chr17:3912370 ZZEF1 0.49 6.58 0.37 2.54e-10 Fibrinogen levels; CESC cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg19748678 chr4:122722346 EXOSC9 0.72 9.4 0.5 2.74e-18 Type 2 diabetes; CESC cis rs1568889 1.000 rs11603799 chr11:28196488 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.58 0.54 4.76e-22 Bipolar disorder; CESC cis rs11048434 0.761 rs1805765 chr12:9094548 A/G cg23795048 chr12:9217529 LOC144571 0.38 5.88 0.34 1.25e-8 Sjögren's syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27067419 chr5:54830434 PPAP2A;RNF138P1 0.63 7.86 0.43 9.83e-14 Gut microbiome composition (summer); CESC trans rs5758511 0.773 rs10154700 chr22:42365073 G/T cg15080870 chr19:47770746 CCDC9 0.5 6.19 0.36 2.26e-9 Birth weight; CESC cis rs35110281 0.627 rs6518268 chr21:44967448 A/G cg01579765 chr21:45077557 HSF2BP -0.49 -8.04 -0.44 2.93e-14 Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16010370 chr3:53290200 TKT 0.46 6.59 0.38 2.36e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs116095464 0.558 rs7725227 chr5:233517 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.24 0.31 3.35e-7 Breast cancer; CESC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg13012494 chr21:47604986 C21orf56 -0.45 -5.99 -0.35 6.77e-9 Testicular germ cell tumor; CESC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.89e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27391037 chr22:18560705 PEX26 -0.44 -6.27 -0.36 1.44e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9916302 0.605 rs12938099 chr17:37612910 T/G cg07936489 chr17:37558343 FBXL20 -0.91 -9.97 -0.52 4.37e-20 Glomerular filtration rate (creatinine); CESC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg03647317 chr4:187891568 NA -0.37 -5.56 -0.32 6.44e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg13298116 chr11:62369859 EML3;MTA2 0.64 9.19 0.49 1.22e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6088580 0.634 rs6059860 chr20:33063830 A/C cg24642439 chr20:33292090 TP53INP2 0.52 6.9 0.39 3.77e-11 Glomerular filtration rate (creatinine); CESC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg05872129 chr22:39784769 NA -0.84 -11.18 -0.57 5.16e-24 Intelligence (multi-trait analysis); CESC cis rs7116495 1.000 rs10898814 chr11:71736505 T/C cg26138937 chr11:71823887 C11orf51 -0.76 -6.07 -0.35 4.41e-9 Severe influenza A (H1N1) infection; CESC cis rs11997175 0.624 rs4621768 chr8:33677452 T/C ch.8.33884649F chr8:33765107 NA 0.58 7.44 0.42 1.44e-12 Body mass index; CESC cis rs2180341 0.618 rs6683 chr6:127610021 G/A cg27446573 chr6:127587934 RNF146 0.62 8.52 0.46 1.22e-15 Breast cancer; CESC cis rs9486715 1.000 rs9486725 chr6:97061159 C/T cg18709589 chr6:96969512 KIAA0776 -0.46 -6.36 -0.36 8.93e-10 Headache; CESC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg22823121 chr1:150693482 HORMAD1 -0.4 -5.43 -0.32 1.25e-7 Blood protein levels; CESC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg04518342 chr5:131593106 PDLIM4 0.43 6.61 0.38 2.05e-10 Acylcarnitine levels; CESC cis rs6582630 0.519 rs7305545 chr12:38349223 G/A cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.62e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg13393036 chr8:95962371 TP53INP1 -0.49 -10.71 -0.55 1.73e-22 Type 2 diabetes; CESC cis rs72627123 0.867 rs73303129 chr14:74489244 A/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.65 0.33 4.06e-8 Morning vs. evening chronotype; CESC cis rs1801251 0.727 rs13029336 chr2:233569935 A/G cg08000102 chr2:233561755 GIGYF2 -0.65 -9.58 -0.51 7.27e-19 Coronary artery disease; CESC trans rs958685 0.766 rs3771503 chr2:70712241 A/G cg20996124 chr1:1144203 NA -0.41 -6.06 -0.35 4.59e-9 Hand grip strength; CESC cis rs7267979 1.000 rs6515651 chr20:25414539 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -16.43 -0.71 2.68e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs4843747 0.619 rs66508972 chr16:88086385 C/G cg06915872 chr16:87998081 BANP 0.45 5.26 0.31 2.94e-7 Menopause (age at onset); CESC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg04166393 chr7:2884313 GNA12 0.53 6.76 0.38 8.84e-11 Height; CESC trans rs35883536 1.000 rs1932351 chr1:101142049 C/T cg16931499 chr17:42786676 DBF4B 0.42 6.26 0.36 1.57e-9 Monocyte count; CESC cis rs367943 0.698 rs2115206 chr5:112999058 A/T cg12552261 chr5:112820674 MCC 0.44 5.77 0.33 2.21e-8 Type 2 diabetes; CESC cis rs16854884 0.657 rs6766685 chr3:143736916 C/T cg06585982 chr3:143692056 C3orf58 0.5 6.7 0.38 1.26e-10 Economic and political preferences (feminism/equality); CESC cis rs12681366 0.708 rs13280849 chr8:95396959 C/A cg13257157 chr8:95487014 RAD54B 0.38 5.14 0.3 5.22e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7586673 0.578 rs6723840 chr2:161879615 G/T cg22496339 chr2:162101262 NA 0.47 6.01 0.35 6.14e-9 Intelligence (multi-trait analysis); CESC cis rs1691799 0.899 rs1168300 chr12:66736467 C/A cg16791601 chr12:66731901 HELB -0.75 -13.03 -0.62 2.51e-30 White blood cell count (basophil); CESC cis rs7923609 0.936 rs4405189 chr10:65013935 A/G cg01631684 chr10:65280961 REEP3 -0.45 -5.53 -0.32 7.73e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs2880765 0.743 rs8032488 chr15:86012768 T/C cg10818794 chr15:86012489 AKAP13 -0.34 -5.26 -0.31 2.99e-7 Coronary artery disease; CESC cis rs1499972 0.938 rs864199 chr3:117755612 T/C cg07612923 chr3:117604196 NA -0.81 -6.04 -0.35 5.25e-9 Schizophrenia; CESC cis rs3126085 0.935 rs1353436 chr1:152172658 G/A cg26876637 chr1:152193138 HRNR 0.44 5.11 0.3 6.25e-7 Atopic dermatitis; CESC cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg11189052 chr15:85197271 WDR73 0.52 7.04 0.4 1.66e-11 P wave terminal force; CESC cis rs9486715 0.929 rs2025044 chr6:97067028 A/G cg06623918 chr6:96969491 KIAA0776 -0.88 -12.55 -0.61 1.13e-28 Headache; CESC cis rs2011503 0.714 rs113980591 chr19:19565357 G/A cg11584989 chr19:19387371 SF4 0.62 6.89 0.39 4.07e-11 Bipolar disorder; CESC cis rs9488822 0.596 rs6568921 chr6:116373616 C/T cg18764771 chr6:116381957 FRK 0.22 5.14 0.3 5.3e-7 Cholesterol, total;LDL cholesterol; CESC cis rs4253772 1.000 rs4253766 chr22:46623905 C/T cg09491104 chr22:46646882 C22orf40 -0.55 -6.41 -0.37 6.62e-10 LDL cholesterol;Cholesterol, total; CESC cis rs2439831 0.850 rs68079546 chr15:44136957 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.46 0.42 1.21e-12 Lung cancer in ever smokers; CESC cis rs9863 0.827 rs12823740 chr12:124458002 C/A cg17562584 chr12:124393655 DNAH10 0.31 5.34 0.31 2.04e-7 White blood cell count; CESC cis rs18122 0.632 rs1483333 chr2:67530280 C/T cg09028215 chr2:67624308 ETAA1 -0.43 -5.28 -0.31 2.67e-7 Waist-to-hip ratio adjusted for body mass index; CESC trans rs12310956 0.515 rs115836245 chr12:33951369 T/C cg26384229 chr12:38710491 ALG10B 0.45 6.39 0.37 7.33e-10 Morning vs. evening chronotype; CESC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg03388025 chr16:89894329 SPIRE2 0.4 7.7 0.43 2.69e-13 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16263627 chr15:100339283 C15orf51 -0.66 -7.88 -0.44 8.52e-14 Gut microbiome composition (summer); CESC cis rs1707322 0.721 rs11211163 chr1:46153548 C/T cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6912958 0.754 rs4587143 chr6:88292291 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -5.34 -0.31 1.99e-7 Monocyte percentage of white cells; CESC cis rs7680126 0.633 rs55766779 chr4:10287039 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -6.07 -0.35 4.32e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs4969178 0.965 rs11077362 chr17:76397219 A/T cg20026190 chr17:76395443 PGS1 0.49 7.81 0.43 1.34e-13 HDL cholesterol levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00840257 chr16:8963031 CARHSP1 -0.44 -6.03 -0.35 5.47e-9 Fibrinogen levels; CESC cis rs561341 1.000 rs757009 chr17:30243937 A/G cg12193833 chr17:30244370 NA -0.52 -5.82 -0.34 1.69e-8 Hip circumference adjusted for BMI; CESC cis rs7223966 1.000 rs8078862 chr17:61854068 C/T cg11494091 chr17:61959527 GH2 0.38 5.18 0.3 4.33e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2274273 0.662 rs67092614 chr14:55672055 G/A cg04306507 chr14:55594613 LGALS3 0.31 5.24 0.31 3.34e-7 Protein biomarker; CESC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.78 10.35 0.54 2.63e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7631605 0.905 rs1468712 chr3:37106013 C/T cg22985146 chr3:37219077 LRRFIP2 0.34 5.51 0.32 8.43e-8 Cerebrospinal P-tau181p levels; CESC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg07507251 chr3:52567010 NT5DC2 0.45 8.39 0.46 2.84e-15 Electroencephalogram traits; CESC cis rs208520 1.000 rs72882100 chr6:66981495 G/C cg07460842 chr6:66804631 NA 0.87 10.16 0.53 1.1e-20 Exhaled nitric oxide output; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg14753042 chr7:55714413 LOC442308 -0.48 -6.5 -0.37 3.94e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs7089973 0.604 rs11196942 chr10:116596872 G/A cg23260525 chr10:116636907 FAM160B1 0.42 7.66 0.43 3.53e-13 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg21285383 chr16:89894308 SPIRE2 0.32 5.69 0.33 3.3e-8 Vitiligo; CESC cis rs17293817 0.562 rs7070629 chr10:1424938 A/G cg04271617 chr10:1416546 ADARB2 -0.32 -5.31 -0.31 2.32e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2034088 0.833 rs11247554 chr17:407465 C/A cg13332499 chr17:408570 NA 0.52 9.08 0.49 2.54e-17 Hip circumference adjusted for BMI; CESC cis rs3815700 1.000 rs8109885 chr19:33095557 A/G cg02997394 chr19:33096574 ANKRD27 0.71 7.09 0.4 1.21e-11 Eosinophilic esophagitis; CESC cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.78 8.21 0.45 9.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg26462404 chr19:2270807 OAZ1 0.46 6.2 0.36 2.21e-9 Weight; CESC cis rs72945132 1.000 rs72945127 chr11:70107650 A/G cg14191688 chr11:70257035 CTTN 0.42 5.22 0.31 3.61e-7 Coronary artery disease; CESC cis rs477692 0.905 rs4751106 chr10:131424653 G/T cg26102564 chr10:131424627 MGMT -0.35 -5.22 -0.31 3.64e-7 Response to temozolomide; CESC cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg12826209 chr6:26865740 GUSBL1 0.75 8.82 0.48 1.62e-16 Intelligence (multi-trait analysis); CESC cis rs2011503 0.941 rs10403273 chr19:19372968 C/G cg11584989 chr19:19387371 SF4 0.54 6.42 0.37 6.34e-10 Bipolar disorder; CESC cis rs17376456 0.569 rs7729807 chr5:93104089 C/T cg25358565 chr5:93447407 FAM172A 0.67 7.04 0.4 1.66e-11 Diabetic retinopathy; CESC cis rs9325144 0.505 rs7955162 chr12:38711658 G/A cg26384229 chr12:38710491 ALG10B 0.69 11.89 0.59 2.07e-26 Morning vs. evening chronotype; CESC cis rs9300255 0.602 rs11057192 chr12:123693420 T/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.51 -0.37 3.65e-10 Neutrophil percentage of white cells; CESC cis rs7666738 0.830 rs10007261 chr4:98926155 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg12463550 chr7:65579703 CRCP -0.53 -6.77 -0.38 8.05e-11 Aortic root size; CESC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg02788857 chr8:22132959 PIWIL2 0.32 5.68 0.33 3.54e-8 Hypertriglyceridemia; CESC trans rs11992162 0.967 rs4841661 chr8:11832769 T/C cg15556689 chr8:8085844 FLJ10661 0.55 6.28 0.36 1.37e-9 Monocyte count; CESC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg04414720 chr1:150670196 GOLPH3L 0.61 8.81 0.48 1.72e-16 Tonsillectomy; CESC cis rs3733585 0.638 rs28715627 chr4:9958140 T/A cg02734326 chr4:10020555 SLC2A9 -0.43 -5.93 -0.34 9.22e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8141529 0.732 rs5762788 chr22:29174770 G/T cg02153584 chr22:29168773 CCDC117 0.72 10.17 0.53 9.68e-21 Lymphocyte counts; CESC cis rs644799 1.000 rs2508289 chr11:95624669 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.83 11.71 0.58 8.53e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7666738 0.830 rs7689495 chr4:98920152 T/C cg05340658 chr4:99064831 C4orf37 0.78 11.59 0.58 2.05e-25 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg08470875 chr2:26401718 FAM59B 0.71 7.06 0.4 1.43e-11 Gut microbiome composition (summer); CESC cis rs3796352 1.000 rs71301809 chr3:53090312 C/T cg12962167 chr3:53033115 SFMBT1 0.7 6.13 0.35 3.23e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg20476274 chr7:133979776 SLC35B4 0.67 9.79 0.52 1.65e-19 Mean platelet volume; CESC cis rs8005677 1.000 rs2295685 chr14:23398153 A/G cg01529538 chr14:23388837 RBM23 0.51 6.84 0.39 5.51e-11 Cognitive ability (multi-trait analysis); CESC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs6693567 0.565 rs1262432 chr1:150371839 C/A cg09579323 chr1:150459698 TARS2 0.48 6.03 0.35 5.61e-9 Migraine; CESC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg01341218 chr17:43662625 NA 0.93 10.8 0.55 9.11e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs10911232 0.507 rs7547953 chr1:183031641 T/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.59 0.64 2.82e-32 Hypertriglyceridemia; CESC cis rs1475911 1.000 rs17114359 chr21:43510437 A/C cg14562523 chr21:43528734 C21orf128;UMODL1 -0.35 -5.17 -0.3 4.7e-7 IgG glycosylation; CESC cis rs7727544 0.735 rs2569266 chr5:131706791 T/C cg24060327 chr5:131705240 SLC22A5 0.68 9.2 0.49 1.14e-17 Blood metabolite levels; CESC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg11890956 chr21:40555474 PSMG1 -0.92 -14.57 -0.67 1.03e-35 Cognitive function; CESC cis rs854765 0.547 rs8075189 chr17:17901946 C/G cg16928487 chr17:17741425 SREBF1 -0.58 -10.22 -0.53 6.92e-21 Total body bone mineral density; CESC cis rs9596863 1.000 rs1379831 chr13:54418506 C/G ch.13.53330881F chr13:54432880 NA 0.62 5.38 0.31 1.64e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs2180341 0.842 rs9375492 chr6:127545492 C/T cg27446573 chr6:127587934 RNF146 -1.01 -12.64 -0.61 5.73e-29 Breast cancer; CESC cis rs870825 0.616 rs28618216 chr4:185648998 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1878931 0.582 rs27239 chr16:3442140 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.7 -8.38 -0.46 3.13e-15 Body mass index (adult); CESC cis rs76878669 0.561 rs1039594 chr11:66131149 C/T cg18002602 chr11:66138449 SLC29A2 0.4 6.65 0.38 1.71e-10 Educational attainment (years of education); CESC cis rs9916302 0.904 rs9898170 chr17:37510092 T/C cg15445000 chr17:37608096 MED1 -0.41 -6.6 -0.38 2.18e-10 Glomerular filtration rate (creatinine); CESC cis rs656900 0.874 rs642697 chr15:80121160 C/T cg02196730 chr15:80188777 MTHFS -0.4 -5.13 -0.3 5.73e-7 Cerebrospinal P-tau181p levels; CESC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg08859206 chr1:53392774 SCP2 0.57 7.13 0.4 9.66e-12 Monocyte count; CESC cis rs3091242 0.933 rs909833 chr1:25754140 C/G cg12412775 chr1:25698385 RHCE -0.29 -5.18 -0.3 4.39e-7 Erythrocyte sedimentation rate; CESC cis rs8014204 0.901 rs2080087 chr14:75365062 C/T cg08847533 chr14:75593920 NEK9 0.44 5.38 0.31 1.61e-7 Caffeine consumption; CESC cis rs9858542 0.953 rs4625 chr3:49572140 A/G cg03060546 chr3:49711283 APEH -0.5 -5.96 -0.34 8.2e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs854765 0.583 rs9890341 chr17:17823175 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.18 0.45 1.22e-14 Total body bone mineral density; CESC cis rs703842 1.000 rs703842 chr12:58162739 C/T cg00677455 chr12:58241039 CTDSP2 -0.52 -6.94 -0.39 2.96e-11 Multiple sclerosis; CESC cis rs7527798 0.571 rs11118237 chr1:207818719 G/A cg21110645 chr1:207815933 NA -0.32 -5.43 -0.32 1.3e-7 Erythrocyte sedimentation rate; CESC cis rs561341 0.769 rs8074383 chr17:30178793 C/T cg19193384 chr17:30244184 NA 0.6 5.7 0.33 3.19e-8 Hip circumference adjusted for BMI; CESC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg26343298 chr8:95960752 TP53INP1 0.36 5.86 0.34 1.35e-8 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07926531 chr1:33546695 ADC 0.64 7.35 0.41 2.39e-12 Gut microbiome composition (summer); CESC cis rs9911578 0.839 rs7208505 chr17:57187729 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.35 0.31 1.87e-7 Intelligence (multi-trait analysis); CESC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg14664628 chr15:75095509 CSK -0.58 -8.1 -0.45 2.07e-14 Breast cancer; CESC cis rs35955747 0.902 rs5997932 chr22:31668154 C/G cg25791279 chr22:32026902 PISD -0.5 -5.96 -0.34 7.84e-9 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg05872129 chr22:39784769 NA -0.81 -9.95 -0.52 5.1e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7552167 1.000 rs7552167 chr1:24518643 A/G cg01960748 chr1:24522592 NA -0.44 -5.9 -0.34 1.11e-8 Psoriasis vulgaris; CESC cis rs17376456 0.877 rs34184666 chr5:93444584 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.11 0.3 6.27e-7 Diabetic retinopathy; CESC cis rs7219021 0.705 rs11869991 chr17:47027763 C/T cg16584676 chr17:46985605 UBE2Z -0.61 -6.99 -0.39 2.2e-11 Schizophrenia or bipolar disorder; CESC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg18099408 chr3:52552593 STAB1 -0.31 -5.09 -0.3 6.65e-7 Bipolar disorder; CESC cis rs6912958 0.500 rs2025486 chr6:87796886 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.39 -5.85 -0.34 1.42e-8 Monocyte percentage of white cells; CESC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg07157834 chr1:205819609 PM20D1 0.74 11.29 0.57 2.21e-24 Menarche (age at onset); CESC cis rs17376456 0.778 rs72786662 chr5:93137630 C/T cg21475434 chr5:93447410 FAM172A 0.85 7.25 0.41 4.66e-12 Diabetic retinopathy; CESC cis rs7131987 0.874 rs10843366 chr12:29407903 T/C cg09582351 chr12:29534625 ERGIC2 -0.35 -5.59 -0.32 5.57e-8 QT interval; CESC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg25036284 chr2:26402008 FAM59B -0.59 -6.69 -0.38 1.35e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.681 rs3212346 chr16:89982358 G/A cg04013166 chr16:89971882 TCF25 0.77 9.0 0.48 4.63e-17 Skin colour saturation; CESC cis rs2429369 0.528 rs2526376 chr17:56427142 A/C cg12560992 chr17:57184187 TRIM37 0.59 7.69 0.43 2.96e-13 Cognitive function; CESC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.73 0.43 2.26e-13 Bipolar disorder; CESC cis rs4654899 0.758 rs6658679 chr1:21376451 T/C cg05370193 chr1:21551575 ECE1 0.35 5.34 0.31 2.04e-7 Superior frontal gyrus grey matter volume; CESC cis rs17001868 0.568 rs470113 chr22:40729614 A/G cg07138101 chr22:40742427 ADSL 0.57 5.52 0.32 8.18e-8 Mammographic density (dense area); CESC cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg09997546 chr11:8931473 C11orf17;ST5 -0.37 -6.41 -0.37 6.74e-10 Hemoglobin concentration; CESC cis rs9399135 0.967 rs9389251 chr6:135325717 A/G cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs708547 0.624 rs1277284 chr4:57855361 T/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.51 -6.97 -0.39 2.51e-11 Response to bleomycin (chromatid breaks); CESC cis rs617791 0.530 rs735942 chr11:65749337 A/G cg09783858 chr11:65769428 EIF1AD;BANF1 0.53 6.35 0.36 9.55e-10 Breast cancer; CESC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg08888203 chr3:10149979 C3orf24 0.49 6.17 0.35 2.49e-9 Alzheimer's disease; CESC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg27535305 chr1:53392650 SCP2 -0.32 -5.19 -0.3 4.2e-7 Monocyte count; CESC cis rs3799378 0.579 rs9348715 chr6:26375642 C/G cg14345882 chr6:26364793 BTN3A2 0.37 5.84 0.34 1.56e-8 Intelligence (multi-trait analysis); CESC cis rs12477438 0.501 rs9941561 chr2:99753829 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.91 15.68 0.69 1.18e-39 Chronic sinus infection; CESC trans rs61931739 0.500 rs35030191 chr12:34548865 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC cis rs2425143 1.000 rs7261284 chr20:34244104 T/A cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.17 0.3 4.59e-7 Blood protein levels; CESC cis rs6831352 0.918 rs1042364 chr4:100045574 T/C cg13256891 chr4:100009986 ADH5 0.74 8.13 0.45 1.63e-14 Alcohol dependence; CESC cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg02297831 chr4:17616191 MED28 0.5 6.12 0.35 3.42e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1707322 1.000 rs4660332 chr1:46461418 T/A cg05343316 chr1:45956843 TESK2 0.5 6.13 0.35 3.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg24733560 chr20:60626293 TAF4 0.49 7.22 0.41 5.59e-12 Body mass index; CESC cis rs116095464 0.867 rs10061296 chr5:312253 G/A cg22857025 chr5:266934 NA -1.21 -10.57 -0.54 4.96e-22 Breast cancer; CESC cis rs1018836 0.923 rs7833025 chr8:91568470 G/C cg16814680 chr8:91681699 NA -0.72 -10.29 -0.53 4.01e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4803468 0.967 rs3213860 chr19:41920211 T/C cg09537434 chr19:41945824 ATP5SL -1.08 -18.9 -0.76 4.86e-51 Height; CESC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg06138931 chr13:21896616 NA 0.47 5.94 0.34 8.88e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg22535103 chr8:58192502 C8orf71 -0.93 -12.03 -0.59 6.97e-27 Developmental language disorder (linguistic errors); CESC cis rs926392 0.533 rs6129162 chr20:37683195 G/A cg16355469 chr20:37678765 NA 0.59 7.12 0.4 1.01e-11 Dialysis-related mortality; CESC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.67 0.33 3.77e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11583043 0.708 rs10493942 chr1:101545482 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 5.17 0.3 4.67e-7 Ulcerative colitis;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00713953 chr2:220462525 STK11IP 0.54 6.34 0.36 9.86e-10 Gut microbiome composition (summer); CESC cis rs910316 1.000 rs175512 chr14:75523382 T/C cg08847533 chr14:75593920 NEK9 -1.0 -19.03 -0.76 1.79e-51 Height; CESC cis rs116095464 0.681 rs10060016 chr5:241100 T/C cg22857025 chr5:266934 NA -1.27 -18.37 -0.75 3.49e-49 Breast cancer; CESC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg03609598 chr5:56110824 MAP3K1 -0.51 -5.54 -0.32 7.18e-8 Initial pursuit acceleration; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg08678925 chr15:85358595 ALPK3 -0.43 -6.26 -0.36 1.52e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs11696501 0.739 rs6073846 chr20:44296323 G/T cg10864404 chr6:43395769 NA 0.53 6.45 0.37 5.32e-10 Brain structure; CESC cis rs9560113 0.550 rs1163632 chr13:112231530 T/C cg10483660 chr13:112241077 NA -0.44 -7.63 -0.42 4.14e-13 Menarche (age at onset); CESC cis rs853679 0.824 rs34712084 chr6:28043828 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.79 6.72 0.38 1.1e-10 Depression; CESC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg22535103 chr8:58192502 C8orf71 -0.92 -10.16 -0.53 1.04e-20 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10378898 chr14:55738124 FBXO34 0.62 7.07 0.4 1.4e-11 Gut microbiome composition (summer); CESC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg15369054 chr17:80825471 TBCD 0.55 7.64 0.42 3.91e-13 Breast cancer; CESC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg21664854 chr7:1097933 C7orf50;GPR146 0.62 6.85 0.39 5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs6963495 0.818 rs73190156 chr7:105153567 C/T cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24858658 chr1:33502741 AK2 -0.44 -6.05 -0.35 5.04e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg11952622 chr19:58962976 ZNF324B 0.44 5.81 0.34 1.83e-8 Uric acid clearance; CESC cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg06022373 chr22:39101656 GTPBP1 0.9 13.91 0.65 2.08e-33 Menopause (age at onset); CESC cis rs2408955 0.500 rs12816820 chr12:48558325 A/G cg04545296 chr12:48745243 ZNF641 0.34 5.78 0.33 2.04e-8 Glycated hemoglobin levels; CESC cis rs7264396 0.635 rs6060696 chr20:34522060 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -11.03 -0.56 1.57e-23 Total cholesterol levels; CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg10819733 chr22:24237672 NA -0.41 -5.83 -0.34 1.64e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6752107 1.000 rs12994997 chr2:234173503 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 6.67 0.38 1.52e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg06634786 chr22:41940651 POLR3H -0.64 -6.69 -0.38 1.35e-10 Vitiligo; CESC cis rs6582630 0.519 rs8189618 chr12:38276281 A/C cg26384229 chr12:38710491 ALG10B 0.68 9.7 0.51 3.2e-19 Drug-induced liver injury (flucloxacillin); CESC cis rs2901656 0.652 rs3213563 chr1:172412995 T/C cg03748243 chr1:172413542 C1orf105;PIGC 0.54 8.28 0.45 5.98e-15 Red cell distribution width;Platelet distribution width; CESC cis rs3796352 1.000 rs59583591 chr3:53119581 T/C cg12962167 chr3:53033115 SFMBT1 0.5 5.23 0.31 3.38e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs1387259 0.859 rs2054905 chr12:48687951 A/G cg24011408 chr12:48396354 COL2A1 0.43 5.96 0.34 7.85e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs748404 0.690 rs2244981 chr15:43752751 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.19 0.45 1.12e-14 Lung cancer; CESC trans rs9354352 0.784 rs2062327 chr6:66689923 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.7 -9.86 -0.52 9.73e-20 Initial pursuit acceleration in psychotic disorders; CESC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg07701084 chr6:150067640 NUP43 0.45 6.39 0.37 7.37e-10 Lung cancer; CESC cis rs117623576 0.941 rs11008775 chr10:32410307 T/C cg03047570 chr10:32398778 NA -0.73 -7.75 -0.43 1.96e-13 Anti-saccade response; CESC cis rs977987 0.806 rs2285225 chr16:75429252 T/C cg03315344 chr16:75512273 CHST6 0.4 5.71 0.33 3e-8 Dupuytren's disease; CESC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg04267008 chr7:1944627 MAD1L1 -0.6 -7.31 -0.41 3.12e-12 Autism spectrum disorder or schizophrenia; CESC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg23985595 chr17:80112537 CCDC57 0.41 6.42 0.37 6.41e-10 Life satisfaction; CESC cis rs9914988 0.943 rs66588554 chr17:27141110 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs897984 0.806 rs10782001 chr16:30942625 G/A cg02466173 chr16:30829666 NA 0.49 8.33 0.46 4.26e-15 Dementia with Lewy bodies; CESC cis rs11583043 0.918 rs6577216 chr1:101409972 C/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.45 5.09 0.3 6.75e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs7598759 0.548 rs1823328 chr2:232355184 G/A cg19187155 chr2:232395269 NMUR1 0.62 10.27 0.53 4.87e-21 Noise-induced hearing loss; CESC cis rs863345 0.604 rs11264997 chr1:158485482 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.91 -0.39 3.53e-11 Pneumococcal bacteremia; CESC cis rs2439831 0.850 rs12440573 chr15:44108997 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.71 0.43 2.55e-13 Lung cancer in ever smokers; CESC cis rs4664293 1.000 rs12692554 chr2:160451288 G/A cg08347373 chr2:160653686 CD302 -0.32 -5.32 -0.31 2.19e-7 Monocyte percentage of white cells; CESC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg08888203 chr3:10149979 C3orf24 0.52 6.09 0.35 3.95e-9 Alzheimer's disease; CESC cis rs7165102 0.965 rs28754459 chr15:65990096 T/C cg11441148 chr15:65824328 PTPLAD1 0.3 5.04 0.3 8.68e-7 Mean corpuscular hemoglobin; CESC cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg22467129 chr15:76604101 ETFA -0.37 -5.48 -0.32 9.79e-8 Blood metabolite levels; CESC cis rs12681366 0.563 rs6999103 chr8:95482537 G/A cg13257157 chr8:95487014 RAD54B 0.45 5.44 0.32 1.22e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs933688 1.000 rs10073935 chr5:90742188 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.96 12.76 0.62 2.16e-29 Smoking behavior; CESC cis rs863345 0.604 rs6666805 chr1:158498305 G/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.15e-11 Pneumococcal bacteremia; CESC cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg22875332 chr1:76189707 ACADM 0.66 7.82 0.43 1.24e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1506636 1.000 rs2429619 chr7:123425599 C/G cg03229431 chr7:123269106 ASB15 0.49 6.56 0.37 2.83e-10 Plateletcrit;Platelet count; CESC trans rs1814175 0.669 rs11040473 chr11:49703813 C/T cg03929089 chr4:120376271 NA -0.72 -9.21 -0.49 1.04e-17 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11118357 chr8:67525492 MYBL1 -0.47 -6.13 -0.35 3.23e-9 Ulcerative colitis; CESC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg06028605 chr16:24865363 SLC5A11 0.54 7.55 0.42 7.16e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs17428076 0.874 rs12619041 chr2:172600716 A/C cg13550731 chr2:172543902 DYNC1I2 -0.46 -5.11 -0.3 6.17e-7 Myopia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25101327 chr2:119981142 STEAP3 -0.46 -6.34 -0.36 9.66e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2463822 1.000 rs11231050 chr11:62131660 C/G cg06239285 chr11:62104954 ASRGL1 -0.94 -8.25 -0.45 7.44e-15 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg04025307 chr7:1156635 C7orf50 0.44 5.31 0.31 2.33e-7 Bronchopulmonary dysplasia; CESC cis rs8040855 0.627 rs72757059 chr15:85603149 C/T cg08123816 chr15:85640762 PDE8A -0.37 -5.56 -0.32 6.5e-8 Bulimia nervosa; CESC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.43e-21 Prudent dietary pattern; CESC cis rs4919694 1.000 rs12266291 chr10:104806884 G/A cg04362960 chr10:104952993 NT5C2 0.79 7.08 0.4 1.27e-11 Arsenic metabolism; CESC cis rs4654899 0.758 rs7521711 chr1:21400218 A/G cg05370193 chr1:21551575 ECE1 0.36 5.48 0.32 1e-7 Superior frontal gyrus grey matter volume; CESC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg21770322 chr7:97807741 LMTK2 0.54 8.13 0.45 1.67e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs28417716 chr4:98864859 C/T cg03467027 chr4:99064603 C4orf37 0.42 5.16 0.3 4.73e-7 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21989500 chr16:23607577 NDUFAB1 -0.43 -6.32 -0.36 1.1e-9 Gambling; CESC cis rs7666738 0.830 rs13110410 chr4:98920018 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.33 0.31 2.06e-7 Colonoscopy-negative controls vs population controls; CESC trans rs8073060 0.586 rs225280 chr17:33976296 C/T cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs2180341 0.618 rs11154396 chr6:127638911 C/T cg27446573 chr6:127587934 RNF146 0.62 8.56 0.47 9.22e-16 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17584303 chr4:1657192 FAM53A 0.45 6.15 0.35 2.79e-9 Fibrinogen levels; CESC cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.78 8.21 0.45 9.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2455799 0.613 rs2470537 chr3:15716898 C/T cg16303742 chr3:15540471 COLQ -0.34 -5.32 -0.31 2.18e-7 Mean platelet volume; CESC cis rs4711336 0.935 rs3818525 chr6:33660779 A/G cg15676125 chr6:33679581 C6orf125 0.34 5.04 0.3 8.58e-7 Height; CESC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19138325 chr12:129429698 GLT1D1 -0.57 -7.21 -0.4 6.03e-12 Gut microbiome composition (summer); CESC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg26338869 chr17:61819248 STRADA 0.67 8.75 0.47 2.55e-16 Prudent dietary pattern; CESC cis rs8141529 0.732 rs6005881 chr22:29183133 A/G cg15103426 chr22:29168792 CCDC117 0.69 9.96 0.52 4.85e-20 Lymphocyte counts; CESC cis rs644799 1.000 rs617999 chr11:95589935 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.73 0.47 2.91e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7843479 0.601 rs3824338 chr8:21864540 A/C cg17168535 chr8:21777572 XPO7 0.7 11.09 0.56 9.93e-24 Mean corpuscular volume; CESC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg23281280 chr6:28129359 ZNF389 0.4 5.7 0.33 3.25e-8 Parkinson's disease; CESC cis rs116095464 0.558 rs1541822 chr5:269234 A/C cg22496380 chr5:211416 CCDC127 0.69 7.87 0.44 8.94e-14 Breast cancer; CESC cis rs6540556 0.608 rs12129718 chr1:209912540 C/T cg05527609 chr1:210001259 C1orf107 -0.55 -6.35 -0.36 9.43e-10 Red blood cell count; CESC cis rs35110281 0.627 rs11701746 chr21:44975137 C/T cg21573476 chr21:45109991 RRP1B -0.4 -5.5 -0.32 9.09e-8 Mean corpuscular volume; CESC cis rs9611565 0.568 rs5751159 chr22:42175365 G/A cg03806693 chr22:41940476 POLR3H 0.78 9.34 0.5 3.97e-18 Vitiligo; CESC cis rs2075371 0.611 rs12707154 chr7:134015832 C/T cg20476274 chr7:133979776 SLC35B4 0.58 7.72 0.43 2.35e-13 Mean platelet volume; CESC cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg06453172 chr10:134556979 INPP5A -0.4 -5.43 -0.32 1.3e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.25 0.36 1.63e-9 Bipolar disorder; CESC cis rs2425143 1.000 rs6060588 chr20:34337480 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.15 0.3 5.14e-7 Blood protein levels; CESC trans rs1814175 0.746 rs10839429 chr11:49906845 G/A cg03929089 chr4:120376271 NA -0.93 -16.26 -0.71 1.03e-41 Height; CESC cis rs6831352 0.879 rs29001215 chr4:100051722 T/C cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.69 -0.33 3.38e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg24675658 chr1:53192096 ZYG11B 0.64 8.96 0.48 5.89e-17 Monocyte count; CESC cis rs11122272 0.766 rs2790872 chr1:231540543 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -6.32 -0.36 1.08e-9 Hemoglobin concentration; CESC cis rs2455799 0.613 rs6795100 chr3:15793798 C/T cg09340198 chr3:15902540 ANKRD28 -0.33 -5.16 -0.3 4.94e-7 Mean platelet volume; CESC cis rs9549260 0.755 rs4941987 chr13:41195992 T/C cg21288729 chr13:41239152 FOXO1 0.62 7.9 0.44 7.34e-14 Red blood cell count; CESC cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg08847533 chr14:75593920 NEK9 -0.83 -13.0 -0.62 3.11e-30 Height; CESC cis rs1215050 0.740 rs700739 chr4:99022546 A/G cg17366294 chr4:99064904 C4orf37 -0.4 -5.26 -0.31 3e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg20119798 chr7:94954144 PON1 -0.38 -5.58 -0.32 5.95e-8 Paraoxonase activity; CESC cis rs12477438 0.822 rs6727170 chr2:99588042 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.95 -0.44 5.43e-14 Chronic sinus infection; CESC cis rs3768617 1.000 rs3768617 chr1:183092500 C/T ch.1.3577855R chr1:183094577 LAMC1 0.65 9.22 0.49 9.46e-18 Fuchs's corneal dystrophy; CESC cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg05585544 chr11:47624801 NA -0.5 -7.5 -0.42 9.62e-13 Subjective well-being; CESC cis rs644799 0.965 rs502521 chr11:95533557 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.13 0.49 1.83e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11690935 0.851 rs7581072 chr2:172859849 C/T cg13550731 chr2:172543902 DYNC1I2 -0.79 -10.76 -0.55 1.25e-22 Schizophrenia; CESC cis rs6866344 0.570 rs56236920 chr5:178144617 C/T cg10224037 chr5:178157518 ZNF354A 0.73 8.42 0.46 2.41e-15 Neutrophil percentage of white cells; CESC cis rs3768617 0.510 rs10797852 chr1:183101302 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 14.34 0.66 6.72e-35 Fuchs's corneal dystrophy; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg13917004 chr19:42462874 RABAC1 -0.48 -6.24 -0.36 1.76e-9 Height; CESC cis rs6963495 0.818 rs73190151 chr7:105152887 C/T cg19920283 chr7:105172520 RINT1 0.69 6.54 0.37 3.09e-10 Bipolar disorder (body mass index interaction); CESC trans rs7839040 0.662 rs7840956 chr8:82929514 C/A cg14472086 chr9:107730925 NA -0.48 -6.33 -0.36 1.03e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg05343316 chr1:45956843 TESK2 -0.5 -6.51 -0.37 3.84e-10 High light scatter reticulocyte count; CESC cis rs1509123 0.609 rs56161809 chr17:6705360 A/T cg12642237 chr17:6703447 TEKT1 -0.62 -5.08 -0.3 7.26e-7 Blood metabolite levels; CESC cis rs7762018 1.000 rs11961560 chr6:170130121 T/C cg13891659 chr6:170190454 C6orf122;C6orf208 0.6 6.14 0.35 3.04e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 10.29 0.53 4.1e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6987853 0.787 rs2923442 chr8:42435493 T/C cg09913449 chr8:42400586 C8orf40 0.45 7.54 0.42 7.31e-13 Mean corpuscular hemoglobin concentration; CESC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.22 -0.36 1.95e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9876781 0.559 rs13073692 chr3:48403302 C/T cg11946769 chr3:48343235 NME6 0.4 5.05 0.3 8.28e-7 Longevity; CESC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg21238619 chr17:78079768 GAA -0.41 -6.17 -0.35 2.54e-9 Yeast infection; CESC cis rs7727544 0.716 rs11949055 chr5:131576737 T/C cg14196790 chr5:131705035 SLC22A5 0.36 5.29 0.31 2.58e-7 Blood metabolite levels; CESC cis rs2066819 0.818 rs703830 chr12:56701872 T/C cg26734620 chr12:56694298 CS -0.92 -9.33 -0.5 4.31e-18 Psoriasis vulgaris; CESC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg26343298 chr8:95960752 TP53INP1 0.37 5.94 0.34 8.73e-9 Type 2 diabetes; CESC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg22903471 chr2:27725779 GCKR -0.46 -6.43 -0.37 5.8e-10 Total body bone mineral density; CESC cis rs208520 0.690 rs1233103 chr6:66855943 T/G cg07460842 chr6:66804631 NA -1.01 -13.48 -0.64 6.84e-32 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03041730 chr4:903314 GAK -0.58 -6.17 -0.35 2.58e-9 Gut microbiome composition (summer); CESC cis rs2014572 0.875 rs10405008 chr19:57753643 C/G cg12963866 chr19:57752005 ZNF805 0.44 5.94 0.34 8.71e-9 Hyperactive-impulsive symptoms; CESC cis rs1832871 0.672 rs12525675 chr6:158708749 A/T cg07165851 chr6:158734300 TULP4 0.61 6.68 0.38 1.38e-10 Height; CESC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg06634786 chr22:41940651 POLR3H -0.64 -6.72 -0.38 1.11e-10 Vitiligo; CESC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg24846343 chr22:24311635 DDTL 0.46 7.28 0.41 3.76e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg10523679 chr1:76189770 ACADM 0.64 6.24 0.36 1.71e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4253772 0.591 rs6007747 chr22:46657261 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.7 8.29 0.45 5.64e-15 LDL cholesterol;Cholesterol, total; CESC cis rs1023500 0.505 rs134899 chr22:42683030 T/G cg04733989 chr22:42467013 NAGA 0.61 9.3 0.5 5.44e-18 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18052550 chr4:166201661 GK3P;KLHL2 -0.61 -7.53 -0.42 7.89e-13 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs881375 0.678 rs4836834 chr9:123665901 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.78 0.38 7.79e-11 Rheumatoid arthritis; CESC cis rs11583043 0.708 rs6577227 chr1:101562132 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 5.47 0.32 1.03e-7 Ulcerative colitis;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07172676 chr8:144997714 PLEC1 -0.57 -6.43 -0.37 6.06e-10 Gut microbiome composition (summer); CESC cis rs6867032 1.000 rs4413568 chr5:2016894 A/G cg26168224 chr5:2018326 NA 1.05 23.85 0.83 6.36e-68 Gut microbiome composition (winter); CESC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg18446336 chr7:2847575 GNA12 -0.37 -5.49 -0.32 9.37e-8 Height; CESC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06080712 chr22:32435515 NA -0.59 -6.94 -0.39 2.96e-11 Gut microbiome composition (summer); CESC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Parkinson's disease; CESC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg21782813 chr7:2030301 MAD1L1 0.43 6.05 0.35 4.98e-9 Bipolar disorder and schizophrenia; CESC trans rs11098499 0.908 rs28499576 chr4:120386677 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.98 0.52 4.04e-20 Corneal astigmatism; CESC cis rs959260 1.000 rs12604003 chr17:73399598 G/A cg12999837 chr17:73267436 MIF4GD -0.52 -5.87 -0.34 1.3e-8 Systemic lupus erythematosus; CESC cis rs11191270 0.590 rs12569901 chr10:104025410 C/G cg15320455 chr10:103880129 LDB1 0.61 5.86 0.34 1.38e-8 Intelligence (multi-trait analysis); CESC cis rs4700695 0.668 rs166180 chr5:65499225 C/T cg21114390 chr5:65439923 SFRS12 -0.48 -5.85 -0.34 1.48e-8 Facial morphology (factor 19); CESC cis rs11630290 0.592 rs1039818 chr15:64155296 A/G cg12036633 chr15:63758958 NA 0.45 5.44 0.32 1.21e-7 Iris characteristics; CESC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg14664628 chr15:75095509 CSK -0.53 -6.71 -0.38 1.17e-10 Breast cancer; CESC cis rs5769765 1.000 rs4597652 chr22:50270570 A/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs644799 0.930 rs631099 chr11:95563482 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.57e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs7188697 0.921 rs12445577 chr16:58587164 T/C cg02549819 chr16:58548995 SETD6 0.43 5.38 0.31 1.64e-7 QT interval; CESC cis rs3105593 1.000 rs11637228 chr15:50899972 G/T cg08437265 chr15:50716283 USP8 0.41 5.37 0.31 1.76e-7 QT interval; CESC cis rs9837602 0.938 rs9814359 chr3:99797013 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.45 6.39 0.37 7.39e-10 Breast cancer; CESC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg04369109 chr6:150039330 LATS1 -0.4 -5.49 -0.32 9.42e-8 Lung cancer; CESC cis rs2066819 1.000 rs11575229 chr12:56750737 C/T cg26734620 chr12:56694298 CS 0.97 5.8 0.34 1.92e-8 Psoriasis vulgaris; CESC cis rs6728642 1.000 rs6728642 chr2:97607071 A/G cg26665480 chr2:98280029 ACTR1B -0.65 -6.53 -0.37 3.32e-10 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs796364 0.806 rs78527234 chr2:200913453 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC cis rs589448 0.535 rs12423794 chr12:69713018 G/A cg14784868 chr12:69753453 YEATS4 0.77 10.88 0.56 4.75e-23 Cerebrospinal fluid biomarker levels; CESC cis rs9611565 0.559 rs12483860 chr22:41961916 C/T cg06481639 chr22:41940642 POLR3H -0.57 -6.38 -0.36 7.88e-10 Vitiligo; CESC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg24562669 chr7:97807699 LMTK2 0.51 7.27 0.41 4.05e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs10992471 0.756 rs10992319 chr9:95127895 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -5.68 -0.33 3.52e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs4891159 0.513 rs35534021 chr18:74130523 G/A cg24786174 chr18:74118243 ZNF516 0.83 15.52 0.69 4.35e-39 Longevity; CESC cis rs9309473 0.519 rs13022145 chr2:73863473 G/A cg20560298 chr2:73613845 ALMS1 0.48 6.77 0.38 8.49e-11 Metabolite levels; CESC cis rs926938 0.563 rs360630 chr1:115415132 C/T cg12756093 chr1:115239321 AMPD1 0.45 6.01 0.35 6.15e-9 Autism; CESC cis rs2295499 0.754 rs12499258 chr4:2715758 G/A cg27239842 chr4:2403781 ZFYVE28 -0.33 -5.55 -0.32 6.84e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg03647317 chr4:187891568 NA -0.44 -6.71 -0.38 1.15e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9309473 1.000 rs10190219 chr2:73658331 C/T cg20560298 chr2:73613845 ALMS1 -0.53 -6.95 -0.39 2.86e-11 Metabolite levels; CESC trans rs9354308 0.903 rs9360158 chr6:66558164 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.5 -6.02 -0.35 5.86e-9 Metabolite levels; CESC cis rs6723226 0.750 rs1033751 chr2:32695759 T/C cg02381751 chr2:32503542 YIPF4 0.53 6.82 0.39 6.05e-11 Intelligence (multi-trait analysis); CESC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg16325326 chr1:53192061 ZYG11B 0.9 15.66 0.69 1.42e-39 Monocyte count; CESC cis rs116979167 0.514 rs1706915 chr7:105196437 A/G cg19920283 chr7:105172520 RINT1 0.5 5.7 0.33 3.17e-8 Bipolar disorder (body mass index interaction); CESC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg05863683 chr7:1912471 MAD1L1 0.37 5.42 0.32 1.35e-7 Bipolar disorder and schizophrenia; CESC trans rs1814175 0.817 rs2866545 chr11:49630824 A/C cg03929089 chr4:120376271 NA -0.9 -14.83 -0.67 1.19e-36 Height; CESC cis rs8114671 0.836 rs6060140 chr20:33566507 G/A cg07148914 chr20:33460835 GGT7 0.43 5.58 0.32 6e-8 Height; CESC cis rs9611565 0.512 rs139566 chr22:42199277 A/G cg06481639 chr22:41940642 POLR3H -0.58 -5.82 -0.34 1.68e-8 Vitiligo; CESC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.51 -0.5 1.23e-18 Alzheimer's disease; CESC cis rs10203711 0.966 rs4998693 chr2:239564753 G/T cg14580085 chr2:239553406 NA 0.34 5.16 0.3 4.74e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg24642844 chr7:1081250 C7orf50 -0.75 -9.03 -0.49 3.61e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6598955 0.543 rs6690461 chr1:26543097 T/A cg04990556 chr1:26633338 UBXN11 0.82 9.16 0.49 1.45e-17 Obesity-related traits; CESC cis rs4975616 0.714 rs37007 chr5:1352372 G/C cg07493874 chr5:1342172 CLPTM1L -0.42 -7.83 -0.43 1.18e-13 Lung cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19586661 chr11:66079705 NA -0.54 -7.21 -0.4 5.85e-12 Ulcerative colitis; CESC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg12310025 chr6:25882481 NA -0.44 -6.38 -0.36 7.94e-10 Intelligence (multi-trait analysis); CESC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.38 -5.23 -0.31 3.39e-7 Lymphocyte counts; CESC cis rs7647973 0.807 rs4955416 chr3:49108428 T/C cg06212747 chr3:49208901 KLHDC8B 0.52 6.23 0.36 1.81e-9 Menarche (age at onset); CESC cis rs2295499 0.673 rs55993221 chr4:2704910 G/T cg27239842 chr4:2403781 ZFYVE28 -0.34 -5.66 -0.33 3.98e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg06074448 chr4:187884817 NA -0.37 -5.43 -0.32 1.27e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg04369109 chr6:150039330 LATS1 -0.46 -6.46 -0.37 4.96e-10 Lung cancer; CESC cis rs1008375 0.966 rs3775925 chr4:17588437 A/G cg16339924 chr4:17578868 LAP3 0.74 9.63 0.51 5.26e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11122272 0.668 rs2472261 chr1:231505701 G/A cg06096015 chr1:231504339 EGLN1 0.39 5.57 0.32 6.39e-8 Hemoglobin concentration; CESC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg26354017 chr1:205819088 PM20D1 0.84 13.62 0.64 2.19e-32 Menarche (age at onset); CESC cis rs7208859 0.623 rs9916725 chr17:29107471 A/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3026101 0.534 rs57303034 chr17:5319003 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.22 0.31 3.64e-7 Body mass index; CESC cis rs7829975 0.682 rs7013471 chr8:8687325 A/G cg15556689 chr8:8085844 FLJ10661 -0.44 -5.41 -0.32 1.44e-7 Mood instability; CESC cis rs6543140 0.964 rs7561351 chr2:103077780 A/G cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs3733585 0.699 rs4408959 chr4:9948868 C/T cg00071950 chr4:10020882 SLC2A9 -0.72 -11.95 -0.59 1.27e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs8031584 0.918 rs1425292 chr15:31285422 G/A cg14298792 chr15:30685198 CHRFAM7A -0.45 -5.33 -0.31 2.08e-7 Huntington's disease progression; CESC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs6912958 0.781 rs7757636 chr6:88256092 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.53 -7.12 -0.4 9.94e-12 Monocyte percentage of white cells; CESC trans rs7615952 0.599 rs2270986 chr3:125701099 T/C cg07211511 chr3:129823064 LOC729375 -0.55 -6.3 -0.36 1.2e-9 Blood pressure (smoking interaction); CESC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg13206674 chr6:150067644 NUP43 0.44 6.35 0.36 9.48e-10 Lung cancer; CESC cis rs561341 0.714 rs474455 chr17:30312465 A/T cg00745463 chr17:30367425 LRRC37B -0.68 -6.9 -0.39 3.9e-11 Hip circumference adjusted for BMI; CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg15112475 chr7:1198522 ZFAND2A -0.45 -7.28 -0.41 3.84e-12 Longevity;Endometriosis; CESC cis rs1568889 0.838 rs11030230 chr11:28174631 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.46 0.64 8.14e-32 Bipolar disorder; CESC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg27170947 chr2:26402098 FAM59B 0.78 9.28 0.5 6.33e-18 Gut microbiome composition (summer); CESC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg25405998 chr7:65216604 CCT6P1 0.52 6.56 0.37 2.75e-10 Calcium levels; CESC cis rs6701037 0.555 rs10912899 chr1:175120715 C/T cg00321850 chr1:175162397 KIAA0040 0.45 6.48 0.37 4.35e-10 Alcohol dependence; CESC cis rs782590 1.000 rs782590 chr2:55843413 C/T cg18811423 chr2:55921094 PNPT1 0.79 12.71 0.62 3.13e-29 Metabolic syndrome; CESC cis rs10751667 0.666 rs6597962 chr11:976351 C/T cg06064525 chr11:970664 AP2A2 -0.51 -9.99 -0.52 3.83e-20 Alzheimer's disease (late onset); CESC trans rs9325144 0.671 rs7485963 chr12:38768254 C/G cg10679878 chr6:156759499 NA -0.34 -6.09 -0.35 4.05e-9 Morning vs. evening chronotype; CESC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg00129232 chr17:37814104 STARD3 0.57 7.67 0.43 3.29e-13 Glomerular filtration rate (creatinine); CESC trans rs877282 0.945 rs34367686 chr10:791868 G/C cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs1348850 0.914 rs7591807 chr2:178252986 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.9 13.34 0.63 2.02e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs12586317 0.514 rs61100068 chr14:35400232 A/T cg16230307 chr14:35515116 FAM177A1 1.08 10.96 0.56 2.63e-23 Psoriasis; CESC cis rs7264396 0.790 rs6058283 chr20:34216276 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.65 0.43 3.84e-13 Total cholesterol levels; CESC cis rs73019876 0.869 rs2522092 chr19:22126992 G/T cg11619707 chr19:22235551 ZNF257 -0.29 -5.22 -0.31 3.61e-7 Testicular germ cell tumor; CESC cis rs9818941 0.910 rs9825122 chr3:157672947 T/C cg08654915 chr3:157813417 NA -0.44 -7.72 -0.43 2.34e-13 Height; CESC cis rs11574514 1.000 rs28679372 chr16:67882932 C/T cg01866162 chr16:67596514 CTCF -0.96 -5.57 -0.32 6.39e-8 Crohn's disease; CESC cis rs2243480 1.000 rs160646 chr7:65556280 C/T cg18252515 chr7:66147081 NA -1.39 -13.8 -0.65 5.05e-33 Diabetic kidney disease; CESC cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg16447950 chr5:562315 NA 0.56 6.13 0.35 3.2e-9 Obesity-related traits; CESC cis rs9660992 0.639 rs1151786 chr1:205227760 G/C cg00857998 chr1:205179979 DSTYK 0.49 5.7 0.33 3.24e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs67311347 1.000 rs9822644 chr3:40426609 G/A cg24209194 chr3:40518798 ZNF619 0.5 6.24 0.36 1.74e-9 Renal cell carcinoma; CESC trans rs8073060 0.586 rs225307 chr17:33918311 A/G cg19694781 chr19:47549865 TMEM160 0.72 6.95 0.39 2.85e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7178572 0.524 rs11853287 chr15:77399371 A/G cg22256960 chr15:77711686 NA -0.54 -6.84 -0.39 5.62e-11 Type 2 diabetes; CESC cis rs4237845 0.537 rs10877031 chr12:58266695 A/G cg02175503 chr12:58329896 NA 0.51 6.08 0.35 4.27e-9 Intelligence (multi-trait analysis); CESC trans rs10242455 0.702 rs2293256 chr7:99057701 A/G cg09045935 chr12:6379348 NA -0.7 -6.02 -0.35 5.93e-9 Blood metabolite levels; CESC cis rs6748734 0.625 rs4675871 chr2:241823849 G/A cg04034577 chr2:241836375 C2orf54 -0.32 -5.63 -0.33 4.69e-8 Urinary metabolites; CESC cis rs9796 0.870 rs28581803 chr15:41326513 G/A cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.84 -0.39 5.38e-11 Menopause (age at onset); CESC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs10754283 0.905 rs7519969 chr1:90108721 G/C cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs34779708 0.966 rs12765038 chr10:35416513 G/C cg03585969 chr10:35415529 CREM 0.77 10.24 0.53 5.78e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs9611565 0.512 rs139572 chr22:42214532 C/T cg03806693 chr22:41940476 POLR3H -1.05 -11.19 -0.57 4.52e-24 Vitiligo; CESC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg11987759 chr7:65425863 GUSB -0.47 -6.42 -0.37 6.18e-10 Calcium levels; CESC cis rs35110281 0.807 rs28840140 chr21:45039163 T/C cg01579765 chr21:45077557 HSF2BP -0.59 -10.12 -0.53 1.43e-20 Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08464520 chr19:56104287 FIZ1 0.47 6.36 0.36 8.59e-10 Fibrinogen levels; CESC trans rs7615952 0.741 rs13314845 chr3:125644782 C/T cg07211511 chr3:129823064 LOC729375 -1.13 -15.5 -0.69 5.37e-39 Blood pressure (smoking interaction); CESC cis rs7191439 0.728 rs8043637 chr16:88781125 T/C cg27087555 chr16:88793112 FAM38A -1.1 -9.05 -0.49 3.07e-17 Plateletcrit; CESC cis rs11098499 0.866 rs13105020 chr4:120285688 G/T cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs11209002 0.567 rs2755269 chr1:67541065 T/C cg02640540 chr1:67518911 SLC35D1 0.47 5.39 0.31 1.52e-7 Crohn's disease; CESC cis rs8070624 0.543 rs11078409 chr17:17876296 C/G cg04398451 chr17:18023971 MYO15A -0.75 -10.67 -0.55 2.48e-22 Total body bone mineral density; CESC cis rs6693567 0.565 rs1313569 chr1:150344171 G/A cg09579323 chr1:150459698 TARS2 0.47 6.05 0.35 4.99e-9 Migraine; CESC cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg19193384 chr17:30244184 NA -0.67 -6.36 -0.36 8.74e-10 Hip circumference adjusted for BMI; CESC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg22903657 chr4:1355424 KIAA1530 -0.38 -5.26 -0.31 2.94e-7 Obesity-related traits; CESC cis rs1707322 0.721 rs4564187 chr1:46166861 G/C cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg17372223 chr3:52568218 NT5DC2 0.45 6.61 0.38 2.11e-10 Bipolar disorder; CESC cis rs7666738 0.830 rs35822567 chr4:98654138 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.39 0.31 1.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg05896524 chr21:47604654 C21orf56 -0.4 -5.18 -0.3 4.41e-7 Testicular germ cell tumor; CESC cis rs11864453 0.560 rs6499561 chr16:72148404 A/G cg01557791 chr16:72042693 DHODH -0.47 -6.34 -0.36 9.86e-10 Fibrinogen levels; CESC cis rs1348850 0.597 rs13014417 chr2:178417835 T/G cg22681709 chr2:178499509 PDE11A -0.53 -6.46 -0.37 5.11e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2657888 0.899 rs7300877 chr12:56933233 C/A cg23002907 chr12:56915593 RBMS2 0.4 5.22 0.31 3.53e-7 Adiponectin levels; CESC cis rs6964587 1.000 rs12704635 chr7:91737324 T/G cg17063962 chr7:91808500 NA 0.56 7.69 0.43 2.96e-13 Breast cancer; CESC cis rs4727963 0.846 rs6968535 chr7:122715438 C/T cg03640110 chr7:122635026 TAS2R16 -0.39 -6.04 -0.35 5.11e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs34779708 0.931 rs11010101 chr10:35411045 T/A cg04310649 chr10:35416472 CREM -0.55 -6.76 -0.38 8.85e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs950776 0.616 rs495090 chr15:78870003 A/G cg06917634 chr15:78832804 PSMA4 -0.5 -6.19 -0.36 2.26e-9 Sudden cardiac arrest; CESC cis rs6009527 1.000 rs2318942 chr22:49573505 G/A cg12746016 chr22:49560550 NA 0.35 5.13 0.3 5.61e-7 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); CESC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg04414720 chr1:150670196 GOLPH3L 0.57 7.47 0.42 1.2e-12 Urate levels; CESC trans rs7824557 0.564 rs2572400 chr8:11234367 T/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.07 -0.35 4.52e-9 Retinal vascular caliber; CESC cis rs208520 0.661 rs704519 chr6:66801136 T/C cg07460842 chr6:66804631 NA -0.99 -13.28 -0.63 3.36e-31 Exhaled nitric oxide output; CESC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg06456125 chr7:65229604 NA -0.4 -5.59 -0.32 5.76e-8 Aortic root size; CESC trans rs801193 1.000 rs7785213 chr7:66138978 A/C cg26939375 chr7:64535504 NA -0.64 -8.64 -0.47 5.52e-16 Aortic root size; CESC cis rs6831352 0.589 rs2602836 chr4:100014805 C/T cg12011299 chr4:100065546 ADH4 -0.75 -10.87 -0.56 5.26e-23 Alcohol dependence; CESC cis rs12042052 1.000 rs72752168 chr1:232922800 G/A cg00951395 chr1:232941775 KIAA1383 0.71 6.48 0.37 4.51e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs9611565 0.506 rs1984839 chr22:41685937 G/C cg03806693 chr22:41940476 POLR3H -0.79 -9.05 -0.49 3.08e-17 Vitiligo; CESC cis rs757110 0.933 rs4148646 chr11:17415190 C/G cg11839944 chr11:17409644 KCNJ11 0.38 5.05 0.3 8.1e-7 Type 2 diabetes; CESC trans rs637571 0.512 rs660118 chr11:65735174 G/C cg17712092 chr4:129076599 LARP1B 0.75 10.32 0.54 3.36e-21 Eosinophil percentage of white cells; CESC cis rs11722228 0.521 rs56403947 chr4:10112529 T/G cg14348967 chr4:10160060 NA -0.41 -5.15 -0.3 5.13e-7 Gout;Urate levels;Serum uric acid levels; CESC cis rs6582630 0.634 rs10748443 chr12:38734062 G/T cg26384229 chr12:38710491 ALG10B 0.56 8.04 0.44 3.07e-14 Drug-induced liver injury (flucloxacillin); CESC cis rs7809950 0.817 rs34325395 chr7:107113808 C/G cg23024343 chr7:107201750 COG5 -0.6 -7.8 -0.43 1.43e-13 Coronary artery disease; CESC cis rs9549367 0.737 rs11619691 chr13:113904636 T/C cg00898013 chr13:113819073 PROZ -0.53 -7.21 -0.41 5.74e-12 Platelet distribution width; CESC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.39 -0.31 1.55e-7 Total body bone mineral density; CESC cis rs1728785 1.000 rs7118 chr16:68600855 G/T cg02972257 chr16:68554789 NA -0.59 -6.75 -0.38 9.22e-11 Ulcerative colitis; CESC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.53 -0.42 7.92e-13 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.56 0.37 2.76e-10 Bipolar disorder; CESC cis rs5167 0.504 rs8100120 chr19:45466058 T/C cg09555818 chr19:45449301 APOC2 0.39 6.18 0.35 2.46e-9 Blood protein levels; CESC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg18446336 chr7:2847575 GNA12 -0.36 -5.65 -0.33 4.18e-8 Height; CESC cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg02297831 chr4:17616191 MED28 0.44 5.64 0.33 4.43e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6032067 0.929 rs56168207 chr20:43803971 C/T cg10761708 chr20:43804764 PI3 0.53 6.29 0.36 1.28e-9 Blood protein levels; CESC cis rs9815354 1.000 rs1716661 chr3:41962818 C/T cg03022575 chr3:42003672 ULK4 -0.46 -5.45 -0.32 1.15e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs3796352 1.000 rs7625448 chr3:53120766 C/A cg12962167 chr3:53033115 SFMBT1 0.53 5.44 0.32 1.22e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs2288073 1.000 rs2288073 chr2:24413298 C/T cg06627628 chr2:24431161 ITSN2 0.78 9.23 0.49 8.93e-18 Venous thromboembolism (SNP x SNP interaction); CESC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.27 -0.31 2.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs938554 0.736 rs4697699 chr4:9945722 T/C cg11266682 chr4:10021025 SLC2A9 -0.38 -5.17 -0.3 4.57e-7 Blood metabolite levels; CESC cis rs12137294 0.866 rs896320 chr1:205205347 T/C cg21643547 chr1:205240462 TMCC2 -0.35 -5.58 -0.32 6.09e-8 Red cell distribution width; CESC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.65 -8.42 -0.46 2.42e-15 Tonsillectomy; CESC cis rs1691799 0.899 rs1168292 chr12:66732660 C/T cg16791601 chr12:66731901 HELB -0.75 -12.9 -0.62 7.25e-30 White blood cell count (basophil); CESC cis rs2712184 0.729 rs2541397 chr2:217646693 G/A cg05032264 chr2:217675019 NA -0.35 -5.32 -0.31 2.26e-7 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC cis rs1950626 0.615 rs12893486 chr14:101463800 C/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.84 9.79 0.52 1.62e-19 Pelvic organ prolapse (moderate/severe); CESC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.39 -0.37 7.61e-10 Total body bone mineral density; CESC cis rs7078219 0.505 rs10883371 chr10:101292455 G/T cg09788492 chr10:101292477 NKX2-3 0.33 6.32 0.36 1.12e-9 Dental caries; CESC cis rs9902453 0.757 rs12453308 chr17:28441604 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 7.88 0.44 8.34e-14 Coffee consumption (cups per day); CESC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg18301423 chr5:131593218 PDLIM4 -0.4 -5.56 -0.32 6.68e-8 Acylcarnitine levels; CESC cis rs7582720 0.806 rs72926770 chr2:203798585 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg05368731 chr17:41323189 NBR1 0.77 10.78 0.55 1.02e-22 Menopause (age at onset); CESC cis rs858239 0.539 rs6949363 chr7:23192394 A/G cg23682824 chr7:23144976 KLHL7 0.5 6.78 0.38 7.91e-11 Cerebrospinal fluid biomarker levels; CESC cis rs80130819 0.636 rs2732470 chr12:48664757 T/G cg05342945 chr12:48394962 COL2A1 -0.48 -5.22 -0.31 3.6e-7 Prostate cancer; CESC cis rs62064224 0.703 rs62065492 chr17:30822607 C/T cg18200150 chr17:30822561 MYO1D 0.75 12.22 0.6 1.55e-27 Schizophrenia; CESC trans rs801193 0.967 rs1110414 chr7:66205582 A/G cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC cis rs7587476 0.784 rs13032278 chr2:215698034 G/A cg04004882 chr2:215674386 BARD1 0.5 5.42 0.32 1.36e-7 Neuroblastoma; CESC cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg05347473 chr6:146136440 FBXO30 -0.57 -7.36 -0.41 2.27e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2204008 0.715 rs3899385 chr12:38169880 C/G cg26384229 chr12:38710491 ALG10B 0.72 10.46 0.54 1.18e-21 Bladder cancer; CESC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg12311346 chr5:56204834 C5orf35 -0.74 -8.84 -0.48 1.38e-16 Initial pursuit acceleration; CESC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg00310523 chr12:86230176 RASSF9 0.41 6.17 0.35 2.61e-9 Major depressive disorder; CESC cis rs7143963 0.609 rs7140494 chr14:103291698 C/T cg24154132 chr14:103367632 TRAF3 -0.36 -6.58 -0.37 2.52e-10 Body mass index; CESC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg19592336 chr6:28129416 ZNF389 0.47 6.85 0.39 5.17e-11 Parkinson's disease; CESC cis rs854765 0.583 rs9913724 chr17:17819101 A/G cg16928487 chr17:17741425 SREBF1 -0.56 -9.74 -0.51 2.34e-19 Total body bone mineral density; CESC cis rs7917772 0.503 rs10748825 chr10:104293609 A/G cg22532475 chr10:104410764 TRIM8 -0.34 -5.81 -0.34 1.82e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs921968 0.541 rs3845835 chr2:219342284 T/C cg02176678 chr2:219576539 TTLL4 -0.55 -9.81 -0.52 1.36e-19 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14520079 chr3:106825871 NA -0.65 -7.46 -0.42 1.26e-12 Gut microbiome composition (summer); CESC cis rs9611565 0.559 rs13056262 chr22:42081921 A/G cg17376030 chr22:41985996 PMM1 -0.79 -8.55 -0.47 9.65e-16 Vitiligo; CESC cis rs6032067 0.850 rs34274189 chr20:43864298 G/T cg10761708 chr20:43804764 PI3 0.49 5.55 0.32 6.82e-8 Blood protein levels; CESC cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg21573476 chr21:45109991 RRP1B -0.46 -6.29 -0.36 1.31e-9 Mean corpuscular volume; CESC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg27572855 chr1:25598939 RHD 0.45 7.53 0.42 7.96e-13 Erythrocyte sedimentation rate; CESC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.95 10.4 0.54 1.85e-21 Mean platelet volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg27026831 chr7:72971748 BCL7B -0.51 -6.07 -0.35 4.4e-9 Ulcerative colitis; CESC cis rs703842 1.000 rs10783848 chr12:58196528 G/A cg00677455 chr12:58241039 CTDSP2 0.53 6.97 0.39 2.45e-11 Multiple sclerosis; CESC cis rs1983891 0.742 rs6920495 chr6:41554182 A/G cg20194872 chr6:41519635 FOXP4 0.48 6.77 0.38 8.28e-11 Prostate cancer; CESC cis rs3820068 0.581 rs72645889 chr1:15930251 T/G cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg17724175 chr1:150552817 MCL1 0.38 5.83 0.34 1.58e-8 Melanoma; CESC trans rs7937682 0.824 rs510866 chr11:111484113 A/C cg18187862 chr3:45730750 SACM1L 0.48 6.03 0.35 5.37e-9 Primary sclerosing cholangitis; CESC cis rs2425143 1.000 rs12480408 chr20:34234800 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -7.67 -0.43 3.27e-13 Blood protein levels; CESC cis rs6594499 0.872 rs7702774 chr5:110460851 G/T cg04022379 chr5:110408740 TSLP 0.33 6.01 0.35 5.98e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg07677032 chr17:61819896 STRADA 0.5 6.7 0.38 1.25e-10 Prudent dietary pattern; CESC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg04414720 chr1:150670196 GOLPH3L 0.62 8.8 0.48 1.76e-16 Tonsillectomy; CESC cis rs7364180 0.515 rs6002503 chr22:42208672 A/G cg03806693 chr22:41940476 POLR3H -0.5 -6.14 -0.35 2.97e-9 Alzheimer's disease biomarkers; CESC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.48 6.24 0.36 1.71e-9 Lymphocyte counts; CESC cis rs72781680 0.898 rs72796166 chr2:23939311 G/C cg08917208 chr2:24149416 ATAD2B 1.1 10.15 0.53 1.18e-20 Lymphocyte counts; CESC cis rs2735413 0.560 rs73562716 chr16:78126415 A/G cg04733911 chr16:78082701 NA 0.43 6.06 0.35 4.54e-9 Systolic blood pressure (alcohol consumption interaction); CESC trans rs9929218 1.000 rs9282650 chr16:68809640 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -8.03 -0.44 3.1e-14 Colorectal cancer; CESC cis rs4835473 0.897 rs35377051 chr4:144658780 A/G cg25736465 chr4:144833511 NA -0.34 -5.3 -0.31 2.46e-7 Immature fraction of reticulocytes; CESC cis rs71277158 0.688 rs76646441 chr3:169885103 A/G cg04067573 chr3:169899625 PHC3 0.71 7.12 0.4 9.93e-12 Prostate cancer; CESC cis rs760805 0.932 rs1005734 chr1:25262022 C/A cg22509179 chr1:25234806 RUNX3 -0.68 -9.96 -0.52 4.52e-20 Allergic disease (asthma, hay fever or eczema); CESC cis rs1003719 0.788 rs2835597 chr21:38466539 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs9584850 0.789 rs7988345 chr13:99117685 A/G cg22223119 chr13:99095684 FARP1 -0.35 -5.03 -0.3 8.85e-7 Neuroticism; CESC cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg16506815 chr2:162101123 NA 0.44 6.0 0.35 6.4e-9 Intelligence (multi-trait analysis); CESC cis rs7666738 0.546 rs28590002 chr4:98722642 C/T cg05340658 chr4:99064831 C4orf37 0.59 7.36 0.41 2.32e-12 Colonoscopy-negative controls vs population controls; CESC cis rs7786808 0.741 rs11769149 chr7:158227127 A/G cg09998033 chr7:158218633 PTPRN2 0.41 6.1 0.35 3.84e-9 Obesity-related traits; CESC cis rs9905704 0.881 rs695137 chr17:56776663 G/A cg12560992 chr17:57184187 TRIM37 0.59 7.01 0.4 1.92e-11 Testicular germ cell tumor; CESC cis rs4523957 0.690 rs4790884 chr17:2105299 G/C cg16513277 chr17:2031491 SMG6 -0.67 -9.25 -0.49 7.79e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs909002 0.800 rs6703093 chr1:32093561 C/T cg13919466 chr1:32135498 COL16A1 -0.46 -8.27 -0.45 6.37e-15 Intelligence (multi-trait analysis); CESC cis rs3026101 0.671 rs12602074 chr17:5302778 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg18180107 chr4:99064573 C4orf37 0.4 5.16 0.3 4.82e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11608355 0.538 rs11611957 chr12:109801803 A/G cg19025524 chr12:109796872 NA -0.51 -7.31 -0.41 3.06e-12 Neuroticism; CESC cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg24130564 chr14:104152367 KLC1 -0.49 -6.46 -0.37 4.98e-10 Reticulocyte count; CESC trans rs1493916 0.967 rs9953765 chr18:31399464 A/G cg27147174 chr7:100797783 AP1S1 -0.52 -7.1 -0.4 1.14e-11 Life satisfaction; CESC cis rs12479064 0.724 rs2309618 chr2:99974473 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -7.8 -0.43 1.4e-13 Chronic sinus infection; CESC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg20887711 chr4:1340912 KIAA1530 0.85 11.49 0.58 4.64e-25 Longevity; CESC cis rs11711311 1.000 rs2566968 chr3:113474154 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.58 7.64 0.42 4.1e-13 IgG glycosylation; CESC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 8.51 0.46 1.27e-15 Platelet count; CESC cis rs11650494 0.522 rs117821438 chr17:47325867 A/T cg08112188 chr17:47440006 ZNF652 1.04 6.47 0.37 4.69e-10 Prostate cancer; CESC cis rs11792861 0.926 rs10512391 chr9:111809530 A/G cg13535736 chr9:111863775 C9orf5 -0.46 -5.77 -0.33 2.25e-8 Menarche (age at onset); CESC cis rs9359856 0.510 rs6937789 chr6:90468775 C/G cg13799429 chr6:90582589 CASP8AP2 0.67 7.27 0.41 3.97e-12 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13581034 chr5:174906090 SFXN1 -0.57 -6.15 -0.35 2.92e-9 Gut microbiome composition (summer); CESC cis rs8005677 0.798 rs35615180 chr14:23404389 T/C cg01529538 chr14:23388837 RBM23 0.43 5.69 0.33 3.3e-8 Cognitive ability (multi-trait analysis); CESC cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg00031303 chr3:195681400 NA 0.47 5.87 0.34 1.27e-8 Pancreatic cancer; CESC cis rs10129255 0.957 rs10142918 chr14:107190443 C/A cg07958169 chr14:107095056 NA -0.39 -5.3 -0.31 2.47e-7 Kawasaki disease; CESC trans rs7246657 0.765 rs7247259 chr19:37851090 T/C cg24637308 chr11:6592297 DNHD1 0.53 6.17 0.35 2.55e-9 Coronary artery calcification; CESC cis rs8027181 0.804 rs34661924 chr15:72994564 A/G cg25632853 chr15:73088954 NA 0.3 5.28 0.31 2.74e-7 Triglyceride levels; CESC cis rs7301826 0.651 rs4759525 chr12:131316281 T/C cg11011512 chr12:131303247 STX2 0.46 5.74 0.33 2.6e-8 Plasma plasminogen activator levels; CESC cis rs847577 0.609 rs6465657 chr7:97816327 C/T cg24562669 chr7:97807699 LMTK2 0.83 13.57 0.64 3.36e-32 Breast cancer; CESC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg03188948 chr7:1209495 NA 0.74 7.3 0.41 3.27e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11098499 0.863 rs10009626 chr4:120470005 T/C cg09307838 chr4:120376055 NA 0.91 12.73 0.62 2.82e-29 Corneal astigmatism; CESC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg18876405 chr7:65276391 NA 0.52 6.87 0.39 4.49e-11 Aortic root size; CESC cis rs8014204 0.905 rs8014289 chr14:75377352 A/G cg08847533 chr14:75593920 NEK9 -0.47 -5.8 -0.34 1.86e-8 Caffeine consumption; CESC cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg10523679 chr1:76189770 ACADM 0.76 10.05 0.53 2.4e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7091068 0.522 rs10882323 chr10:95483280 T/C cg20715218 chr10:95462985 C10orf4 0.5 5.89 0.34 1.14e-8 Urinary tract infection frequency; CESC cis rs2742234 0.955 rs2435384 chr10:43673731 G/T cg07801480 chr10:43725741 RASGEF1A 0.37 5.29 0.31 2.58e-7 Hirschsprung disease; CESC cis rs9660992 0.710 rs1668873 chr1:205235990 G/A cg21643547 chr1:205240462 TMCC2 -0.49 -6.67 -0.38 1.45e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs1707322 1.000 rs4660889 chr1:46297331 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.47 0.32 1.02e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1707322 0.963 rs10890373 chr1:46393755 A/C cg05343316 chr1:45956843 TESK2 0.51 6.24 0.36 1.71e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8063761 0.640 rs4785760 chr16:90051438 G/A cg08547343 chr16:90038815 CENPBD1;AFG3L1 0.65 9.59 0.51 6.71e-19 Squamous cell carcinoma; CESC cis rs11792861 0.816 rs28361186 chr9:111704064 G/A cg13535736 chr9:111863775 C9orf5 -0.47 -6.26 -0.36 1.57e-9 Menarche (age at onset); CESC cis rs7937682 0.889 rs1789355 chr11:111499718 T/C cg22437258 chr11:111473054 SIK2 0.7 9.18 0.49 1.31e-17 Primary sclerosing cholangitis; CESC cis rs6951245 0.542 rs28460147 chr7:1217192 G/A cg18402987 chr7:1209562 NA 0.77 8.33 0.46 4.24e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22776125 chr6:167041314 RPS6KA2 0.54 7.13 0.4 9.79e-12 Gut microbiota (bacterial taxa); CESC cis rs9916302 0.706 rs649180 chr17:37464959 A/C cg07936489 chr17:37558343 FBXL20 0.95 10.45 0.54 1.24e-21 Glomerular filtration rate (creatinine); CESC cis rs1707322 1.000 rs10789485 chr1:46407308 C/T cg05343316 chr1:45956843 TESK2 0.5 6.13 0.35 3.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8114671 0.742 rs6058161 chr20:33620026 C/T cg07148914 chr20:33460835 GGT7 -0.41 -5.31 -0.31 2.28e-7 Height; CESC cis rs1878931 0.582 rs9921152 chr16:3421199 A/G cg02880119 chr16:3481970 NA -0.4 -5.22 -0.31 3.67e-7 Body mass index (adult); CESC cis rs2425143 1.000 rs6060557 chr20:34270266 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -7.53 -0.42 8.04e-13 Blood protein levels; CESC trans rs4671386 0.901 rs2160068 chr2:60522090 T/C cg24386296 chr4:1723849 TMEM129;TACC3 0.51 6.39 0.37 7.28e-10 Acne (severe); CESC cis rs2425143 1.000 rs117010355 chr20:34343442 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -7.55 -0.42 6.87e-13 Blood protein levels; CESC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg26587870 chr6:27730563 NA -0.59 -5.3 -0.31 2.44e-7 Depression; CESC cis rs3091242 0.933 rs11249251 chr1:25770188 C/G cg03538708 chr1:25844672 NA -0.38 -5.69 -0.33 3.37e-8 Erythrocyte sedimentation rate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18216292 chr1:155920810 ARHGEF2 0.49 6.82 0.39 6.08e-11 Fibrinogen levels; CESC cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.55 -0.32 6.86e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7586879 0.638 rs10203482 chr2:25136916 T/C cg01884057 chr2:25150051 NA 0.41 7.92 0.44 6.63e-14 Body mass index; CESC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.54 0.54 6.22e-22 Height; CESC cis rs9303401 0.659 rs16943176 chr17:56769887 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC cis rs2718058 0.519 rs2722242 chr7:37873610 A/G cg24998770 chr7:37888106 TXNDC3 -0.32 -5.12 -0.3 5.88e-7 Alzheimer's disease (late onset); CESC cis rs365132 0.818 rs251843 chr5:176476106 A/G cg16309518 chr5:176445507 NA -0.38 -5.53 -0.32 7.74e-8 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs62103177 0.608 rs551643 chr18:77838970 C/G cg12964065 chr18:77638022 KCNG2 -0.44 -5.13 -0.3 5.53e-7 Opioid sensitivity; CESC cis rs16957304 1.000 rs3868143 chr16:67328453 C/T cg26727032 chr16:67993705 SLC12A4 0.52 5.2 0.3 4.04e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs2072732 0.821 rs58052947 chr1:2950094 T/C cg03976712 chr1:2946727 NA 0.32 5.45 0.32 1.13e-7 Plateletcrit; CESC cis rs8017423 0.967 rs12889636 chr14:90689953 A/C cg14092571 chr14:90743983 NA 0.52 7.58 0.42 6e-13 Mortality in heart failure; CESC cis rs9611565 0.694 rs202637 chr22:41853928 A/G cg17376030 chr22:41985996 PMM1 -0.7 -7.2 -0.4 6.1e-12 Vitiligo; CESC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg00933542 chr6:150070202 PCMT1 -0.31 -5.33 -0.31 2.14e-7 Lung cancer; CESC cis rs11122272 0.735 rs2437147 chr1:231516756 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs17666538 0.535 rs1669658 chr8:607380 A/G cg23958373 chr8:599963 NA 0.81 6.21 0.36 2.04e-9 IgG glycosylation; CESC cis rs10918270 0.838 rs9783050 chr1:161936020 A/G cg19735514 chr1:161762739 ATF6 -0.38 -5.6 -0.33 5.26e-8 Parkinson's disease (age of onset); CESC cis rs1580019 0.587 rs9638880 chr7:32552401 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.68 0.38 1.44e-10 Cognitive ability; CESC cis rs1003719 0.788 rs2156076 chr21:38452634 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.64 8.79 0.48 1.93e-16 Eye color traits; CESC cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg05340658 chr4:99064831 C4orf37 0.79 11.76 0.59 5.78e-26 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 1.000 rs28497813 chr4:17685503 A/G cg16339924 chr4:17578868 LAP3 0.51 6.55 0.37 2.98e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2625529 0.878 rs16956302 chr15:72136243 C/T cg16672083 chr15:72433130 SENP8 -0.43 -5.34 -0.31 1.95e-7 Red blood cell count; CESC cis rs17125944 1.000 rs17125924 chr14:53391680 A/G cg00686598 chr14:53173677 PSMC6 0.8 5.79 0.33 2.02e-8 Alzheimer's disease (late onset); CESC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs763121 0.888 rs2235229 chr22:39124912 A/G cg06544989 chr22:39130855 UNC84B 0.43 8.07 0.44 2.5e-14 Menopause (age at onset); CESC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg26335602 chr6:28129616 ZNF389 0.53 7.09 0.4 1.19e-11 Depression; CESC cis rs654950 0.901 rs1885654 chr1:42007188 C/A cg06885757 chr1:42089581 HIVEP3 -0.63 -9.94 -0.52 5.5e-20 Airway imaging phenotypes; CESC cis rs28374715 0.578 rs72739630 chr15:41631064 G/A cg20272979 chr15:41787780 ITPKA 0.44 5.2 0.3 4.02e-7 Ulcerative colitis; CESC cis rs4561483 0.815 rs11646545 chr16:11934594 T/G cg08843971 chr16:11963173 GSPT1 0.52 7.46 0.42 1.23e-12 Testicular germ cell tumor; CESC cis rs7726839 0.540 rs11750321 chr5:599196 C/T cg16447950 chr5:562315 NA -0.6 -6.05 -0.35 4.91e-9 Obesity-related traits; CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg16132339 chr22:24313637 DDTL;DDT 0.41 6.22 0.36 1.9e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7827545 1.000 rs6578229 chr8:135562453 T/G cg17885191 chr8:135476712 NA 0.45 6.05 0.35 4.94e-9 Hypertension (SNP x SNP interaction); CESC trans rs8026198 0.568 rs1659213 chr15:42624699 C/T cg13954090 chr10:73533106 CDH23;C10orf54 -0.7 -6.11 -0.35 3.47e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19955521 chr10:1102667 WDR37 0.57 6.88 0.39 4.21e-11 Gut microbiome composition (summer); CESC cis rs11203032 0.901 rs7098394 chr10:90960906 T/A cg16672925 chr10:90967113 CH25H 0.75 7.18 0.4 7.13e-12 Heart failure; CESC cis rs7824557 0.564 rs13260727 chr8:11232860 A/G cg21775007 chr8:11205619 TDH 0.49 7.02 0.4 1.83e-11 Retinal vascular caliber; CESC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg12963246 chr6:28129442 ZNF389 0.56 7.62 0.42 4.43e-13 Depression; CESC cis rs16937 0.574 rs10900455 chr1:205123534 T/C cg00857998 chr1:205179979 DSTYK 0.4 5.35 0.31 1.92e-7 Schizophrenia; CESC cis rs76878669 0.538 rs73489638 chr11:66127639 C/T cg18002602 chr11:66138449 SLC29A2 -0.41 -6.77 -0.38 8.14e-11 Educational attainment (years of education); CESC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg12963246 chr6:28129442 ZNF389 0.54 7.12 0.4 1.02e-11 Depression; CESC cis rs4561483 0.801 rs33637 chr16:11989875 A/T cg08843971 chr16:11963173 GSPT1 -0.56 -8.18 -0.45 1.23e-14 Testicular germ cell tumor; CESC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg16325326 chr1:53192061 ZYG11B 0.93 16.13 0.7 3.13e-41 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24849267 chr2:172374169 NA -0.56 -6.28 -0.36 1.36e-9 Gut microbiome composition (summer); CESC cis rs459571 0.916 rs467303 chr9:136904835 C/T cg13789015 chr9:136890014 NCRNA00094 0.54 7.69 0.43 2.98e-13 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06895349 chr6:26197261 HIST1H3D 0.56 6.34 0.36 9.82e-10 Gut microbiome composition (summer); CESC cis rs8072100 0.967 rs12452315 chr17:45479446 G/T cg25173405 chr17:45401733 C17orf57 0.39 5.26 0.31 2.91e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg04756594 chr16:24857601 SLC5A11 0.48 5.22 0.31 3.7e-7 Intelligence (multi-trait analysis); CESC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg10541313 chr22:46663664 TTC38 0.71 5.69 0.33 3.36e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6439153 0.933 rs7648877 chr3:128709980 T/C cg24203234 chr3:128598194 ACAD9 0.43 5.59 0.32 5.56e-8 Pneumococcal bacteremia; CESC cis rs9303280 0.901 rs9901146 chr17:38043343 G/A cg19468946 chr17:37922297 IKZF3 -0.42 -5.63 -0.33 4.53e-8 Self-reported allergy; CESC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg23758822 chr17:41437982 NA 1.03 15.62 0.69 2.01e-39 Menopause (age at onset); CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg12912258 chr5:131630175 SLC22A4 0.48 6.38 0.36 7.92e-10 Myopia (pathological); CESC cis rs6433857 0.505 rs12471899 chr2:181369856 C/T cg23363182 chr2:181467187 NA -0.42 -5.87 -0.34 1.28e-8 Body mass index; CESC cis rs2243480 1.000 rs4718269 chr7:65200778 C/G cg12463550 chr7:65579703 CRCP -0.65 -5.08 -0.3 6.99e-7 Diabetic kidney disease; CESC cis rs1124376 1.000 rs1124376 chr3:20108546 A/G cg05072819 chr3:20081367 KAT2B -0.59 -6.16 -0.35 2.62e-9 Bipolar disorder and schizophrenia; CESC cis rs6963495 0.556 rs711433 chr7:105153191 A/G cg13798780 chr7:105162888 PUS7 -0.49 -6.07 -0.35 4.39e-9 Bipolar disorder (body mass index interaction); CESC cis rs7208859 0.673 rs11653955 chr17:29033292 C/A cg13385521 chr17:29058706 SUZ12P 0.82 6.37 0.36 8.09e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1595825 0.945 rs73058818 chr2:198862600 C/T cg00982548 chr2:198649783 BOLL -0.49 -5.58 -0.32 5.98e-8 Ulcerative colitis; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg03971247 chr2:46841077 PIGF 0.38 6.29 0.36 1.34e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs644799 0.542 rs10831416 chr11:95467220 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.5 6.53 0.37 3.28e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg16680214 chr1:154839983 KCNN3 -0.45 -6.94 -0.39 2.95e-11 Prostate cancer; CESC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg24060327 chr5:131705240 SLC22A5 -0.78 -11.01 -0.56 1.85e-23 Breast cancer; CESC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg23161317 chr6:28129485 ZNF389 0.44 5.72 0.33 2.8e-8 Depression; CESC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.21 -0.36 2.01e-9 Schizophrenia; CESC cis rs1957429 0.614 rs73279812 chr14:65348012 G/A cg23373153 chr14:65346875 NA -0.9 -6.61 -0.38 2.11e-10 Pediatric areal bone mineral density (radius); CESC trans rs12429889 0.831 rs11620053 chr13:74751444 T/C cg03455107 chr17:54509207 ANKFN1 0.34 6.03 0.35 5.36e-9 Sudden cardiac arrest; CESC cis rs733592 0.560 rs2158515 chr12:48507668 T/C cg04545296 chr12:48745243 ZNF641 -0.29 -5.29 -0.31 2.55e-7 Plateletcrit; CESC trans rs11098499 0.645 rs72676059 chr4:120290828 C/G cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs916888 0.610 rs142167 chr17:44795234 C/T cg01570182 chr17:44337453 NA -0.68 -9.33 -0.5 4.28e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2197308 0.619 rs4002730 chr12:37876400 T/C cg26384229 chr12:38710491 ALG10B 0.74 10.98 0.56 2.29e-23 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.65 0.64 1.8e-32 Prudent dietary pattern; CESC cis rs9911578 1.000 rs8067571 chr17:56868856 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.24 0.31 3.23e-7 Intelligence (multi-trait analysis); CESC cis rs765787 0.530 rs4270107 chr15:45535350 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs2974760 0.606 rs6600143 chr16:201389 A/C cg08400316 chr16:204221 HBZ -0.65 -11.11 -0.56 8.51e-24 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs1448094 0.511 rs11610371 chr12:86163487 A/G cg00310523 chr12:86230176 RASSF9 0.35 5.76 0.33 2.3e-8 Major depressive disorder; CESC cis rs10927875 0.632 rs10927863 chr1:16165247 C/A cg21385522 chr1:16154831 NA -1.02 -17.11 -0.72 1.05e-44 Dilated cardiomyopathy; CESC cis rs9291683 0.546 rs4529049 chr4:10045389 C/T cg11266682 chr4:10021025 SLC2A9 0.65 12.39 0.61 3.92e-28 Bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17609050 chr7:92861606 CCDC132 -0.43 -6.11 -0.35 3.53e-9 Gambling; CESC cis rs10504073 0.584 rs11784268 chr8:49956339 T/G cg00325661 chr8:49890786 NA 0.59 8.9 0.48 9.3e-17 Blood metabolite ratios; CESC cis rs2243480 1.000 rs451396 chr7:65484074 T/A cg18252515 chr7:66147081 NA -1.19 -11.57 -0.58 2.56e-25 Diabetic kidney disease; CESC cis rs7615952 0.611 rs2947646 chr3:125593602 C/T cg05084668 chr3:125655381 ALG1L 0.73 7.89 0.44 7.91e-14 Blood pressure (smoking interaction); CESC cis rs7395581 0.879 rs3758673 chr11:47278917 C/T cg25783544 chr11:47291846 MADD 0.6 7.8 0.43 1.47e-13 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20725539 chr19:9695373 ZNF121 0.57 6.5 0.37 4.02e-10 Gut microbiome composition (summer); CESC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg21433313 chr16:3507492 NAT15 0.5 7.85 0.43 1.02e-13 Tuberculosis; CESC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.6 0.64 2.58e-32 Prudent dietary pattern; CESC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg23985595 chr17:80112537 CCDC57 0.41 6.42 0.37 6.41e-10 Life satisfaction; CESC cis rs9522267 0.535 rs7329118 chr13:112232693 C/T cg10483660 chr13:112241077 NA -0.33 -5.83 -0.34 1.65e-8 Hepatitis; CESC cis rs6088580 0.634 rs4258875 chr20:32924895 C/A cg24642439 chr20:33292090 TP53INP2 -0.52 -6.77 -0.38 8.14e-11 Glomerular filtration rate (creatinine); CESC cis rs3733585 0.648 rs7378305 chr4:9954893 C/T cg02734326 chr4:10020555 SLC2A9 -0.41 -5.79 -0.33 2.02e-8 Cleft plate (environmental tobacco smoke interaction); CESC trans rs459571 0.959 rs461462 chr9:136911272 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.57 -7.48 -0.42 1.1e-12 Platelet distribution width; CESC cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg04455712 chr21:45112962 RRP1B 0.39 5.96 0.34 7.84e-9 Mean corpuscular volume; CESC cis rs6723226 0.721 rs3769600 chr2:32616879 G/A cg02381751 chr2:32503542 YIPF4 -0.54 -6.79 -0.39 7.3e-11 Intelligence (multi-trait analysis); CESC cis rs1270639 0.722 rs6950817 chr7:157439636 A/G cg13357408 chr7:157437802 PTPRN2 0.61 6.99 0.39 2.24e-11 Colorectal cancer; CESC cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg13628971 chr7:2884303 GNA12 0.41 5.47 0.32 1.06e-7 Height; CESC cis rs8020095 0.571 rs7156852 chr14:67340549 T/G cg19548862 chr14:67692701 FAM71D -0.5 -6.06 -0.35 4.73e-9 Depression (quantitative trait); CESC cis rs17253792 0.545 rs12893676 chr14:56016159 G/A cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs2777491 0.872 rs61037359 chr15:41585926 T/C cg02330683 chr15:41787940 ITPKA 0.42 6.21 0.36 2e-9 Ulcerative colitis; CESC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg10295955 chr4:187884368 NA -1.05 -19.92 -0.77 1.36e-54 Lobe attachment (rater-scored or self-reported); CESC cis rs4595586 0.525 rs34204378 chr12:39425759 C/T cg13010199 chr12:38710504 ALG10B 0.43 5.19 0.3 4.24e-7 Morning vs. evening chronotype; CESC cis rs7208859 0.673 rs9907197 chr17:29018263 C/T cg19761014 chr17:28927070 LRRC37B2 0.67 5.99 0.35 6.81e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs61776719 0.747 rs28428561 chr1:38434306 G/A cg17077180 chr1:38461687 NA -0.55 -8.49 -0.46 1.48e-15 Coronary artery disease; CESC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg07414643 chr4:187882934 NA -0.53 -7.57 -0.42 6.21e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg05255149 chr17:80675120 FN3KRP -0.48 -5.64 -0.33 4.28e-8 Breast cancer; CESC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg11764359 chr7:65958608 NA -0.93 -14.88 -0.67 8.32e-37 Aortic root size; CESC cis rs9291683 0.597 rs11723016 chr4:10126189 A/G cg00071950 chr4:10020882 SLC2A9 -0.55 -8.51 -0.46 1.33e-15 Bone mineral density; CESC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg27535305 chr1:53392650 SCP2 0.32 5.68 0.33 3.6e-8 Monocyte count; CESC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs3960554 0.808 rs13438599 chr7:75768022 G/A cg17325771 chr7:75508891 RHBDD2 -0.34 -5.06 -0.3 7.71e-7 Eotaxin levels; CESC cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg27057461 chr7:158136379 PTPRN2 -0.34 -5.29 -0.31 2.58e-7 Calcium levels; CESC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.34 0.36 9.62e-10 Bipolar disorder; CESC cis rs14057 0.896 rs2232460 chr1:6659505 G/A cg06778853 chr1:6672620 PHF13 -0.27 -5.04 -0.3 8.74e-7 Systolic blood pressure; CESC cis rs2243480 1.000 rs1546059 chr7:65654709 C/A cg12463550 chr7:65579703 CRCP -0.73 -5.66 -0.33 4.03e-8 Diabetic kidney disease; CESC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg22903471 chr2:27725779 GCKR -0.5 -7.11 -0.4 1.08e-11 Total body bone mineral density; CESC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg27121462 chr16:89883253 FANCA -0.46 -5.38 -0.31 1.66e-7 Vitiligo; CESC cis rs7666738 0.830 rs35531558 chr4:98938217 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs131777 0.575 rs963980 chr22:51022117 C/A cg00083937 chr22:51039805 MAPK8IP2 0.4 5.73 0.33 2.72e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs6460942 0.908 rs77034890 chr7:12244506 A/T cg20607287 chr7:12443886 VWDE -0.62 -6.03 -0.35 5.41e-9 Coronary artery disease; CESC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg24060327 chr5:131705240 SLC22A5 0.76 10.91 0.56 3.9699999999999997e-23 Breast cancer; CESC cis rs478304 0.934 rs12801731 chr11:65549606 T/C cg08755490 chr11:65554678 OVOL1 0.52 6.73 0.38 1.03e-10 Acne (severe); CESC cis rs11958404 1.000 rs72816538 chr5:157414303 A/G cg05962755 chr5:157440814 NA 0.52 6.01 0.35 6.19e-9 IgG glycosylation; CESC cis rs3857536 0.813 rs4710581 chr6:66939954 T/C cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01499736 chr6:36164655 BRPF3 0.58 6.78 0.38 7.78e-11 Gut microbiome composition (summer); CESC cis rs3741151 1.000 rs7125978 chr11:73039229 G/A cg17517138 chr11:73019481 ARHGEF17 0.62 5.33 0.31 2.12e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg21573476 chr21:45109991 RRP1B -0.47 -6.64 -0.38 1.8e-10 Mean corpuscular volume; CESC cis rs1018836 0.884 rs2073640 chr8:91594853 A/G cg16814680 chr8:91681699 NA -0.71 -10.37 -0.54 2.21e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs933688 1.000 rs332544 chr5:90778848 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.03 13.78 0.65 6.06e-33 Smoking behavior; CESC cis rs977987 0.843 rs4888427 chr16:75478447 A/G cg03315344 chr16:75512273 CHST6 0.43 6.23 0.36 1.77e-9 Dupuytren's disease; CESC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC trans rs12339966 0.643 rs2586341 chr9:11678273 G/T cg03904639 chr13:37677730 CSNK1A1L 0.39 6.06 0.35 4.67e-9 Systolic blood pressure; CESC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg04553112 chr3:125709451 NA -0.5 -5.48 -0.32 9.86e-8 Blood pressure (smoking interaction); CESC cis rs55883249 1.000 rs57234614 chr2:9756379 T/C cg23886495 chr2:9695866 ADAM17 0.62 5.66 0.33 3.83e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04723601 chr11:60681193 TMEM109 -0.56 -6.39 -0.37 7.58e-10 Gut microbiome composition (summer); CESC cis rs6662572 1.000 rs72688452 chr1:46092365 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 5.73 0.33 2.66e-8 Blood protein levels; CESC cis rs7264396 0.635 rs6060682 chr20:34506331 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.22 -0.57 3.58e-24 Total cholesterol levels; CESC cis rs4561483 0.549 rs6498251 chr16:11952290 A/G cg08843971 chr16:11963173 GSPT1 0.52 7.26 0.41 4.2e-12 Testicular germ cell tumor; CESC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.63e-10 Life satisfaction; CESC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg03452623 chr4:187889614 NA -0.88 -16.16 -0.7 2.39e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs2197308 0.740 rs11182967 chr12:37935140 A/C cg13010199 chr12:38710504 ALG10B 0.53 6.81 0.39 6.71e-11 Morning vs. evening chronotype; CESC cis rs3820068 0.705 rs72643694 chr1:15860185 C/T cg18192808 chr1:15853278 DNAJC16 0.48 5.91 0.34 1.03e-8 Systolic blood pressure; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12102766 chr2:105954037 C2orf49 -0.53 -6.64 -0.38 1.77e-10 Ulcerative colitis; CESC cis rs9512730 0.553 rs1007701 chr13:28049143 C/G cg08193333 chr13:27998609 GTF3A -0.45 -5.32 -0.31 2.18e-7 Schizophrenia; CESC cis rs11168351 0.927 rs7971880 chr12:48391055 C/T cg24011408 chr12:48396354 COL2A1 0.53 8.08 0.44 2.23e-14 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg03467027 chr4:99064603 C4orf37 0.45 5.61 0.33 4.97e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg21280719 chr6:42927975 GNMT -0.29 -6.75 -0.38 9.55e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg02034447 chr16:89574710 SPG7 0.55 6.99 0.39 2.17e-11 Multiple myeloma (IgH translocation); CESC cis rs561341 0.556 rs542244 chr17:30307242 T/C cg12193833 chr17:30244370 NA -0.7 -6.48 -0.37 4.5e-10 Hip circumference adjusted for BMI; CESC cis rs868036 0.609 rs13329413 chr15:68097126 C/T cg08079166 chr15:68083412 MAP2K5 0.42 5.8 0.34 1.86e-8 Restless legs syndrome; CESC cis rs11098499 0.863 rs9884402 chr4:120489982 A/G cg24375607 chr4:120327624 NA 0.46 5.59 0.32 5.73e-8 Corneal astigmatism; CESC cis rs854765 0.964 rs72827413 chr17:17988299 C/T cg16928487 chr17:17741425 SREBF1 0.57 9.73 0.51 2.47e-19 Total body bone mineral density; CESC cis rs2933343 0.951 rs789218 chr3:128592670 G/A cg25356066 chr3:128598488 ACAD9 0.57 6.87 0.39 4.45e-11 IgG glycosylation; CESC trans rs2623325 0.874 rs6440580 chr3:99111135 A/G cg19595760 chr1:25948511 MAN1C1 0.46 6.09 0.35 3.98e-9 Optic cup area;Vertical cup-disc ratio; CESC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg06456125 chr7:65229604 NA -0.48 -6.33 -0.36 1.04e-9 Aortic root size; CESC cis rs3820928 0.804 rs4144327 chr2:227790262 C/T cg11843606 chr2:227700838 RHBDD1 -0.44 -5.87 -0.34 1.29e-8 Pulmonary function; CESC cis rs11122272 0.735 rs2437147 chr1:231516756 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs11098499 0.954 rs11940028 chr4:120411907 T/C cg24375607 chr4:120327624 NA 0.46 5.63 0.33 4.52e-8 Corneal astigmatism; CESC cis rs1348850 0.632 rs13009207 chr2:178501632 A/G cg23306229 chr2:178417860 TTC30B 0.58 7.61 0.42 4.82e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg26116260 chr4:7069785 GRPEL1 -0.83 -9.37 -0.5 3.38e-18 Monocyte percentage of white cells; CESC cis rs947211 0.898 rs10900524 chr1:205748309 G/A cg17178900 chr1:205818956 PM20D1 0.41 5.27 0.31 2.9e-7 Parkinson's disease; CESC cis rs1707322 1.000 rs6429580 chr1:46275648 A/G cg03146154 chr1:46216737 IPP 0.73 10.13 0.53 1.3e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2797160 0.935 rs1739372 chr6:126011325 G/A cg05039488 chr6:79577232 IRAK1BP1 0.45 5.99 0.35 6.67e-9 Endometrial cancer; CESC cis rs6060717 0.536 rs2425104 chr20:34312346 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.29 0.31 2.61e-7 Hip circumference adjusted for BMI; CESC cis rs3820928 0.934 rs16822890 chr2:227761477 G/A cg05526886 chr2:227700861 RHBDD1 -0.42 -5.5 -0.32 8.95e-8 Pulmonary function; CESC cis rs9911578 0.967 rs2429369 chr17:56501420 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.73 0.69 7.77e-40 Intelligence (multi-trait analysis); CESC cis rs11792861 0.781 rs874864 chr9:111728718 C/T cg05043794 chr9:111880884 C9orf5 -0.38 -6.6 -0.38 2.22e-10 Menarche (age at onset); CESC cis rs425277 1.000 rs262676 chr1:2078482 T/A cg04315214 chr1:2043799 PRKCZ -0.38 -5.3 -0.31 2.42e-7 Height; CESC cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg08564027 chr20:61660810 NA 0.9 15.44 0.69 8.75e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs6496667 0.557 rs2601201 chr15:90958000 C/T cg10434728 chr15:90938212 IQGAP1 0.33 5.76 0.33 2.33e-8 Rheumatoid arthritis; CESC cis rs8031584 0.918 rs1425292 chr15:31285422 G/A cg14829155 chr15:31115871 NA -0.73 -9.78 -0.51 1.78e-19 Huntington's disease progression; CESC cis rs96067 0.711 rs795047 chr1:36637708 C/T cg24686825 chr1:36642396 MAP7D1 0.43 5.95 0.34 8.34e-9 Corneal structure; CESC cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg20307385 chr11:47447363 PSMC3 -0.62 -7.42 -0.41 1.58e-12 Subjective well-being; CESC cis rs9486715 0.867 rs9373907 chr6:96981189 G/A cg18709589 chr6:96969512 KIAA0776 0.46 6.47 0.37 4.7e-10 Headache; CESC cis rs2180341 0.920 rs4472373 chr6:127705983 G/A cg24812749 chr6:127587940 RNF146 1.05 14.91 0.68 6.23e-37 Breast cancer; CESC cis rs2731664 0.792 rs2630764 chr5:176880085 C/T cg23176889 chr5:176863531 GRK6 -0.66 -11.73 -0.58 6.91e-26 Intelligence (multi-trait analysis); CESC cis rs4566357 0.615 rs12618793 chr2:227909552 T/C cg11843606 chr2:227700838 RHBDD1 -0.48 -6.54 -0.37 3.2e-10 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08494708 chr6:108881870 FOXO3 0.62 7.41 0.41 1.71e-12 Gut microbiome composition (summer); CESC cis rs3820928 1.000 rs11692572 chr2:227774503 C/G cg05526886 chr2:227700861 RHBDD1 -0.43 -5.51 -0.32 8.62e-8 Pulmonary function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15731816 chr14:75230414 YLPM1 0.51 6.85 0.39 5.11e-11 Gut microbiota (bacterial taxa); CESC cis rs4073582 0.595 rs1115508 chr11:65923149 A/G cg14036092 chr11:66035641 RAB1B 0.55 7.83 0.43 1.17e-13 Gout; CESC cis rs10838687 0.736 rs7120158 chr11:47265194 G/C cg25783544 chr11:47291846 MADD 0.57 6.63 0.38 1.91e-10 Proinsulin levels; CESC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg02353165 chr6:42928485 GNMT 0.88 15.24 0.68 4.23e-38 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9787249 0.957 rs10888958 chr1:40211737 T/C cg24920358 chr1:40204285 PPIE 0.42 6.37 0.36 8.16e-10 Blood protein levels; CESC cis rs7631605 0.905 rs1399178 chr3:37258669 G/A cg22985146 chr3:37219077 LRRFIP2 -0.35 -5.51 -0.32 8.64e-8 Cerebrospinal P-tau181p levels; CESC cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 6.36 0.36 8.58e-10 Eosinophil percentage of white cells; CESC cis rs6088590 0.687 rs6088580 chr20:33285053 G/C cg06115741 chr20:33292138 TP53INP2 0.52 6.49 0.37 4.1e-10 Coronary artery disease; CESC cis rs7666738 0.830 rs7678250 chr4:98922109 G/A cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg12311346 chr5:56204834 C5orf35 0.87 10.7 0.55 1.85e-22 Initial pursuit acceleration; CESC cis rs2688608 0.592 rs11000760 chr10:75493734 G/A cg23231163 chr10:75533350 FUT11 -0.34 -5.27 -0.31 2.82e-7 Inflammatory bowel disease; CESC trans rs1814175 0.817 rs28502006 chr11:50049930 T/C cg15704280 chr7:45808275 SEPT13 -1.05 -21.04 -0.79 1.87e-58 Height; CESC cis rs11098499 0.954 rs3733520 chr4:120423480 C/G cg09307838 chr4:120376055 NA 0.96 13.89 0.65 2.55e-33 Corneal astigmatism; CESC cis rs7044106 0.762 rs10760115 chr9:123476952 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.12 0.53 1.48e-20 Hip circumference adjusted for BMI; CESC cis rs12545109 0.879 rs1581129 chr8:57377476 T/C cg09654669 chr8:57350985 NA -0.57 -6.67 -0.38 1.46e-10 Obesity-related traits; CESC cis rs6493487 0.512 rs7170364 chr15:51123027 G/A cg02338191 chr15:51200825 AP4E1 0.51 5.19 0.3 4.29e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7937682 0.632 rs10789850 chr11:111750829 C/T cg22437258 chr11:111473054 SIK2 -0.49 -5.46 -0.32 1.1e-7 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03569283 chr8:142222314 SLC45A4 -0.55 -6.39 -0.37 7.52e-10 Gut microbiome composition (summer); CESC cis rs1865760 0.566 rs1971509 chr6:26085777 T/C cg16482183 chr6:26056742 HIST1H1C 0.38 5.11 0.3 6.19e-7 Height; CESC cis rs9316337 0.557 rs9509659 chr13:21924162 A/G cg18095732 chr13:22033692 ZDHHC20 -0.47 -5.78 -0.33 2.1e-8 Schizophrenia; CESC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg13607699 chr17:42295918 UBTF 0.56 7.28 0.41 3.88e-12 Total body bone mineral density; CESC cis rs116095464 0.558 rs59284383 chr5:284525 C/G cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.41 0.32 1.38e-7 Breast cancer; CESC cis rs10197940 0.624 rs4461258 chr2:152429679 A/G cg19508488 chr2:152266495 RIF1 -0.46 -5.06 -0.3 8e-7 Lung cancer; CESC cis rs7666738 0.518 rs13133925 chr4:98706398 G/T cg17366294 chr4:99064904 C4orf37 0.49 6.11 0.35 3.59e-9 Colonoscopy-negative controls vs population controls; CESC cis rs8002861 0.905 rs12853286 chr13:44446817 A/G cg14210620 chr13:44453864 C13orf31;CCDC122 -0.45 -5.64 -0.33 4.33e-8 Leprosy; CESC cis rs9811920 0.609 rs2452320 chr3:99645216 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg13206674 chr6:150067644 NUP43 0.41 5.68 0.33 3.47e-8 Lung cancer; CESC trans rs61931739 0.517 rs2101396 chr12:34048927 T/A cg26384229 chr12:38710491 ALG10B 0.51 6.94 0.39 2.97e-11 Morning vs. evening chronotype; CESC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg26119090 chr2:26468346 HADHA;HADHB 0.81 8.71 0.47 3.25e-16 Gut microbiome composition (summer); CESC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg24503407 chr1:205819492 PM20D1 0.79 12.46 0.61 2.34e-28 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09804439 chr17:40540457 STAT3 0.54 6.12 0.35 3.35e-9 Gut microbiome composition (summer); CESC cis rs1552244 0.748 rs9862221 chr3:10059658 G/T cg13047869 chr3:10149882 C3orf24 0.43 5.27 0.31 2.85e-7 Alzheimer's disease; CESC cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg06753689 chr10:1034030 GTPBP4 0.5 5.05 0.3 8.33e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs7980687 0.574 rs10744149 chr12:123708490 T/A cg05973401 chr12:123451056 ABCB9 0.47 5.29 0.31 2.63e-7 Height;Educational attainment;Head circumference (infant); CESC cis rs6120849 0.754 rs17319032 chr20:33643296 T/C cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs7584330 0.704 rs72620821 chr2:238362615 C/A cg14458575 chr2:238380390 NA 0.89 11.75 0.59 5.91e-26 Prostate cancer; CESC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg18490616 chr2:88469792 THNSL2 0.54 5.07 0.3 7.54e-7 Plasma clusterin levels; CESC cis rs870825 0.587 rs35377170 chr4:185639728 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC cis rs3733585 0.673 rs4467564 chr4:9953472 G/T cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg19077165 chr18:44547161 KATNAL2 -0.53 -7.75 -0.43 1.94e-13 Personality dimensions; CESC cis rs7772486 0.875 rs9322044 chr6:146369608 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.5 0.37 3.88e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00841781 chr22:51021511 LOC100144603;CHKB-CPT1B;CHKB 0.56 6.16 0.35 2.62e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs2777479 chr6:146309178 C/A cg05347473 chr6:146136440 FBXO30 0.54 7.04 0.4 1.66e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs10465746 0.967 rs12757632 chr1:84416408 T/C cg10977910 chr1:84465055 TTLL7 0.49 6.58 0.37 2.51e-10 Obesity-related traits; CESC cis rs13343954 0.518 rs8106293 chr19:33536376 C/T cg17764715 chr19:33622953 WDR88 0.55 7.54 0.42 7.64e-13 Colorectal cancer; CESC cis rs733592 0.965 rs1978161 chr12:48467721 A/G cg24011408 chr12:48396354 COL2A1 -0.51 -7.81 -0.43 1.36e-13 Plateletcrit; CESC cis rs11677370 0.561 rs13015012 chr2:3821252 C/G cg17052675 chr2:3827356 NA 0.41 5.31 0.31 2.37e-7 Type 2 diabetes; CESC cis rs9487051 0.676 rs7773213 chr6:109601885 C/T cg21918786 chr6:109611834 NA -0.39 -5.74 -0.33 2.56e-8 Reticulocyte fraction of red cells; CESC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs2115630 0.645 rs4842978 chr15:85197253 T/C cg12501888 chr15:85177176 SCAND2 -0.46 -6.06 -0.35 4.58e-9 P wave terminal force; CESC cis rs9309711 0.922 rs11679058 chr2:3483813 C/G cg10845886 chr2:3471009 TTC15 -0.89 -12.76 -0.62 2.13e-29 Neurofibrillary tangles; CESC cis rs7568498 0.517 rs11678856 chr2:161925443 C/T cg22496339 chr2:162101262 NA -0.52 -5.62 -0.33 4.95e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.54 -6.76 -0.38 8.91e-11 Prudent dietary pattern; CESC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg07308232 chr7:1071921 C7orf50 -0.48 -6.89 -0.39 4.16e-11 Longevity;Endometriosis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14895945 chr19:12889086 NA -0.49 -6.62 -0.38 1.96e-10 Asthma; CESC cis rs7843479 0.509 rs3758156 chr8:21770796 A/G cg17168535 chr8:21777572 XPO7 0.63 9.46 0.5 1.74e-18 Mean corpuscular volume; CESC cis rs7762018 1.000 rs4509126 chr6:170068058 A/G cg05834625 chr6:170176447 C6orf70 0.62 7.35 0.41 2.48e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2228479 0.850 rs74251570 chr16:89910068 C/A cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg13880726 chr7:1868755 MAD1L1 -0.5 -6.73 -0.38 1.02e-10 Bipolar disorder and schizophrenia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg14797243 chr11:68671428 IGHMBP2;MRPL21 0.5 6.68 0.38 1.41e-10 Systemic lupus erythematosus; CESC cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg02487422 chr3:49467188 NICN1 0.46 5.84 0.34 1.53e-8 Parkinson's disease; CESC cis rs9486715 1.000 rs2273621 chr6:97058553 A/G cg06623918 chr6:96969491 KIAA0776 -0.89 -12.98 -0.62 3.77e-30 Headache; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02458088 chr16:77228411 MON1B 0.47 6.29 0.36 1.29e-9 Fibrinogen levels; CESC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg19717773 chr7:2847554 GNA12 -0.53 -7.62 -0.42 4.54e-13 Height; CESC cis rs1904096 0.506 rs6841121 chr4:95222995 G/A cg11021082 chr4:95130006 SMARCAD1 -0.62 -10.1 -0.53 1.67e-20 Type 2 diabetes; CESC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg23172400 chr8:95962367 TP53INP1 -0.47 -9.92 -0.52 6.36e-20 Type 2 diabetes; CESC cis rs3008870 0.755 rs4655661 chr1:67408828 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.63 8.34 0.46 4.16e-15 Lymphocyte percentage of white cells; CESC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.57 7.98 0.44 4.5e-14 Personality dimensions; CESC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.3 0.6 8.13e-28 Alzheimer's disease; CESC cis rs6840360 0.533 rs13121190 chr4:152729072 T/G cg22705602 chr4:152727874 NA 0.37 5.07 0.3 7.32e-7 Intelligence (multi-trait analysis); CESC cis rs6060717 0.610 rs2590964 chr20:34613376 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -7.92 -0.44 6.36e-14 Hip circumference adjusted for BMI; CESC cis rs950169 0.723 rs17589320 chr15:84919996 C/A cg17507749 chr15:85114479 UBE2QP1 0.57 6.33 0.36 1.07e-9 Schizophrenia; CESC cis rs11031096 0.502 rs720571 chr11:4001328 G/T cg18678763 chr11:4115507 RRM1 -0.48 -6.47 -0.37 4.8e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.51e-9 Developmental language disorder (linguistic errors); CESC cis rs2625529 0.775 rs16956273 chr15:72117102 C/T cg16672083 chr15:72433130 SENP8 -0.49 -7.32 -0.41 2.92e-12 Red blood cell count; CESC cis rs4604732 0.536 rs12074913 chr1:247631607 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 5.96 0.34 7.9e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg19592336 chr6:28129416 ZNF389 0.62 8.12 0.45 1.77e-14 Depression; CESC trans rs11098499 0.730 rs78971550 chr4:120281041 C/T cg25214090 chr10:38739885 LOC399744 0.67 9.02 0.48 3.81e-17 Corneal astigmatism; CESC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg08859206 chr1:53392774 SCP2 -0.56 -7.4 -0.41 1.83e-12 Monocyte count; CESC cis rs941873 0.838 rs2233713 chr10:81107135 A/C cg09469691 chr10:81107165 PPIF 0.59 7.98 0.44 4.31e-14 Height; CESC cis rs7267979 0.844 rs6083851 chr20:25401235 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -14.64 -0.67 5.69e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs3741151 0.773 rs58564192 chr11:73228904 G/A cg17517138 chr11:73019481 ARHGEF17 1.05 7.72 0.43 2.46e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7089973 0.836 rs1046492 chr10:116624067 C/T cg23260525 chr10:116636907 FAM160B1 0.38 6.47 0.37 4.62e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs78889164 0.614 rs8111593 chr19:33851076 G/A cg02272751 chr19:33882848 PEPD -0.37 -5.48 -0.32 9.97e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs317689 0.684 rs315125 chr12:69758884 C/T cg14784868 chr12:69753453 YEATS4 0.64 7.44 0.42 1.36e-12 Response to diuretic therapy; CESC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg08470875 chr2:26401718 FAM59B 0.7 7.23 0.41 5.17e-12 Gut microbiome composition (summer); CESC trans rs826838 0.709 rs4882355 chr12:38721462 A/T cg23762105 chr12:34175262 ALG10 -0.48 -6.38 -0.36 7.96e-10 Heart rate; CESC cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg10523679 chr1:76189770 ACADM 0.76 9.99 0.52 3.63e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7116495 1.000 rs4945434 chr11:71759087 A/G cg26138937 chr11:71823887 C11orf51 0.91 7.39 0.41 1.86e-12 Severe influenza A (H1N1) infection; CESC cis rs897984 0.609 rs12445650 chr16:31044897 G/A cg02466173 chr16:30829666 NA -0.39 -6.7 -0.38 1.28e-10 Dementia with Lewy bodies; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05707704 chr2:73144283 EMX1 -0.48 -6.62 -0.38 1.93e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg17376030 chr22:41985996 PMM1 -0.79 -8.34 -0.46 4.18e-15 Crohn's disease;Inflammatory bowel disease; CESC cis rs11785400 0.793 rs11543967 chr8:143739435 A/G cg10596483 chr8:143751796 JRK -0.43 -5.27 -0.31 2.88e-7 Schizophrenia; CESC cis rs861020 0.582 rs630065 chr1:209998662 C/T cg05527609 chr1:210001259 C1orf107 0.74 9.63 0.51 5.29e-19 Orofacial clefts; CESC cis rs3820928 0.874 rs10194663 chr2:227875369 T/A cg11843606 chr2:227700838 RHBDD1 -0.46 -5.8 -0.34 1.84e-8 Pulmonary function; CESC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.5 0.5 1.34e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.13.1524792R chr13:99552827 DOCK9 0.46 6.8 0.39 7.07e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7219021 0.674 rs9904761 chr17:46956830 C/G cg16584676 chr17:46985605 UBE2Z -0.57 -6.85 -0.39 5.06e-11 Schizophrenia or bipolar disorder; CESC cis rs1348850 0.872 rs13004955 chr2:178398923 A/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.82 -11.06 -0.56 1.29e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07020338 chr15:41099895 ZFYVE19;DNAJC17 0.57 6.02 0.35 5.91e-9 Gut microbiome composition (summer); CESC cis rs116095464 0.542 rs28650039 chr5:273954 C/A cg20965017 chr5:231967 SDHA -0.49 -5.48 -0.32 9.73e-8 Breast cancer; CESC cis rs1045714 0.779 rs3735113 chr7:2651563 G/A cg20813462 chr7:2646259 IQCE 0.66 5.62 0.33 4.95e-8 Urate levels in lean individuals; CESC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg07308232 chr7:1071921 C7orf50 -0.43 -6.03 -0.35 5.52e-9 Longevity;Endometriosis; CESC cis rs1475911 1.000 rs17114359 chr21:43510437 A/C cg19766460 chr21:43528205 UMODL1;C21orf128 0.53 5.93 0.34 9.52e-9 IgG glycosylation; CESC cis rs17384381 0.700 rs11161616 chr1:85907625 A/G cg16011679 chr1:85725395 C1orf52 -0.61 -6.43 -0.37 6.03e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg17724175 chr1:150552817 MCL1 0.38 5.85 0.34 1.42e-8 Melanoma; CESC cis rs5769765 0.865 rs3788730 chr22:50244695 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.47 5.47 0.32 1.07e-7 Schizophrenia; CESC cis rs9837602 0.872 rs4928234 chr3:99704861 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.53 -7.24 -0.41 4.82e-12 Breast cancer; CESC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg06873352 chr17:61820015 STRADA 0.73 12.93 0.62 5.59e-30 Prudent dietary pattern; CESC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.51 0.37 3.8e-10 Depression; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03330302 chr2:26468406 HADHA;HADHB 0.45 6.51 0.37 3.75e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg26839252 chr6:160211577 TCP1;MRPL18 0.49 5.42 0.32 1.32e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs4148883 0.603 rs6833176 chr4:100131163 G/C cg13256891 chr4:100009986 ADH5 -0.46 -6.08 -0.35 4.13e-9 Alcohol dependence; CESC cis rs6977660 0.507 rs72591449 chr7:19775443 T/C cg07541023 chr7:19748670 TWISTNB 0.8 7.21 0.4 6.02e-12 Thyroid stimulating hormone; CESC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg27535305 chr1:53392650 SCP2 0.35 6.23 0.36 1.78e-9 Monocyte count; CESC trans rs11165623 0.792 rs13375510 chr1:96920723 A/G cg10631902 chr5:14652156 NA -0.55 -8.26 -0.45 7.06e-15 Hip circumference;Waist circumference; CESC cis rs709400 1.000 rs6593 chr14:104163282 G/A cg12935359 chr14:103987150 CKB -0.46 -6.21 -0.36 2.08e-9 Body mass index; CESC cis rs2742234 0.554 rs1254963 chr10:43696086 C/T cg07801480 chr10:43725741 RASGEF1A -0.41 -5.33 -0.31 2.14e-7 Hirschsprung disease; CESC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg21285383 chr16:89894308 SPIRE2 0.31 5.47 0.32 1.03e-7 Vitiligo; CESC cis rs62103177 0.810 rs62103188 chr18:77627661 G/A cg12964065 chr18:77638022 KCNG2 0.58 5.46 0.32 1.07e-7 Opioid sensitivity; CESC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.42 -0.37 6.22e-10 Depression; CESC cis rs963731 0.649 rs1377861 chr2:39293858 T/C cg04010122 chr2:39346883 SOS1 -0.78 -5.91 -0.34 1.06e-8 Corticobasal degeneration; CESC cis rs10751667 0.643 rs7396407 chr11:929374 A/T cg06064525 chr11:970664 AP2A2 -0.52 -10.25 -0.53 5.74e-21 Alzheimer's disease (late onset); CESC cis rs8067354 0.872 rs1292060 chr17:57913849 A/G cg13753209 chr17:57696993 CLTC 0.48 6.62 0.38 1.99e-10 Hemoglobin concentration; CESC cis rs977987 0.585 rs62059845 chr16:75430713 A/G cg03315344 chr16:75512273 CHST6 0.4 5.71 0.33 3e-8 Dupuytren's disease; CESC cis rs8141529 0.748 rs1318025 chr22:29283757 C/T cg02153584 chr22:29168773 CCDC117 0.59 7.62 0.42 4.62e-13 Lymphocyte counts; CESC cis rs7072216 0.763 rs45523432 chr10:100167436 T/C cg26618903 chr10:100175079 PYROXD2 -0.36 -5.49 -0.32 9.42e-8 Metabolite levels; CESC cis rs6570726 0.935 rs385134 chr6:145851005 C/T cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 2e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.583 rs8065563 chr17:17782404 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.51 6.51 0.37 3.71e-10 Total body bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01628954 chr18:60190696 ZCCHC2 -0.46 -6.79 -0.38 7.16e-11 Gambling; CESC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg05313129 chr8:58192883 C8orf71 -0.54 -6.58 -0.37 2.56e-10 Developmental language disorder (linguistic errors); CESC cis rs9911578 0.900 rs4793593 chr17:56892699 C/G cg05425664 chr17:57184151 TRIM37 0.48 6.73 0.38 1.06e-10 Intelligence (multi-trait analysis); CESC cis rs6429082 1.000 rs6429082 chr1:235600129 C/T cg26050004 chr1:235667680 B3GALNT2 0.45 6.0 0.35 6.47e-9 Adiposity; CESC cis rs13095912 1.000 rs2034343 chr3:185337854 A/T cg11274856 chr3:185301563 NA 0.33 5.25 0.31 3.19e-7 Systolic blood pressure; CESC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg18876405 chr7:65276391 NA -0.53 -7.3 -0.41 3.35e-12 Aortic root size; CESC cis rs6500395 1.000 rs9933187 chr16:48556573 A/C cg04672837 chr16:48644449 N4BP1 -0.47 -5.57 -0.32 6.29e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg16325326 chr1:53192061 ZYG11B -0.71 -11.92 -0.59 1.62e-26 Monocyte count; CESC cis rs6089584 0.507 rs6061990 chr20:60628429 T/G cg24733560 chr20:60626293 TAF4 0.44 6.55 0.37 2.93e-10 Body mass index; CESC cis rs6701037 0.566 rs4344281 chr1:175135376 C/T cg00321850 chr1:175162397 KIAA0040 0.44 6.32 0.36 1.11e-9 Alcohol dependence; CESC cis rs3815700 1.000 rs8108840 chr19:33094452 A/C cg02997394 chr19:33096574 ANKRD27 0.68 6.36 0.36 8.94e-10 Eosinophilic esophagitis; CESC cis rs10851478 0.872 rs6493372 chr15:49758729 T/C cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.16 0.3 4.79e-7 Oral cavity cancer; CESC cis rs2073300 1.000 rs6137960 chr20:23442886 G/A cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4481887 1.000 rs10888360 chr1:248479282 G/A cg00666640 chr1:248458726 OR2T12 0.39 6.34 0.36 9.68e-10 Common traits (Other); CESC cis rs2425143 1.000 rs10485510 chr20:34445164 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 7.86e-12 Blood protein levels; CESC cis rs6594499 1.000 rs1438673 chr5:110467499 C/T cg04022379 chr5:110408740 TSLP 0.3 5.14 0.3 5.35e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg02896835 chr1:92012615 NA -0.56 -7.79 -0.43 1.51e-13 Breast cancer; CESC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg26338869 chr17:61819248 STRADA 0.71 9.41 0.5 2.51e-18 Prudent dietary pattern; CESC cis rs7264396 0.673 rs2425163 chr20:34432670 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.61 7.24 0.41 4.81e-12 Total cholesterol levels; CESC cis rs7000551 0.715 rs1600877 chr8:22378118 C/T cg12081754 chr8:22256438 SLC39A14 0.41 5.46 0.32 1.08e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs7605827 0.930 rs2287276 chr2:15660254 A/G cg19274914 chr2:15703543 NA 0.37 6.67 0.38 1.47e-10 Educational attainment (years of education); CESC cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg20644253 chr19:19431407 KIAA0892;SF4 0.56 7.0 0.4 2.1e-11 Tonsillectomy; CESC cis rs2228479 0.717 rs17226274 chr16:89850170 C/T cg14709524 chr16:89940631 TCF25 0.82 6.43 0.37 6.08e-10 Skin colour saturation; CESC cis rs12477438 0.501 rs11692336 chr2:99740606 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 12.89 0.62 7.58e-30 Chronic sinus infection; CESC trans rs1557351 0.723 rs6566850 chr18:54723394 T/C cg11433624 chr6:7146702 RREB1 0.37 6.06 0.35 4.6e-9 Multiple sclerosis (age of onset); CESC cis rs12137294 0.794 rs1172160 chr1:205207015 G/A cg21643547 chr1:205240462 TMCC2 -0.35 -5.65 -0.33 4.24e-8 Red cell distribution width; CESC cis rs9487051 0.652 rs9372210 chr6:109601703 G/C cg21918786 chr6:109611834 NA -0.37 -5.39 -0.31 1.55e-7 Reticulocyte fraction of red cells; CESC cis rs6570726 0.967 rs7772286 chr6:145930423 A/T cg23711669 chr6:146136114 FBXO30 -0.81 -11.73 -0.58 7.17e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs9309473 0.500 rs4852953 chr2:73869908 G/A cg20560298 chr2:73613845 ALMS1 0.46 6.36 0.36 8.78e-10 Metabolite levels; CESC cis rs9815354 0.812 rs73071352 chr3:41828300 A/G cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23668004 chr7:4784903 FOXK1 -0.41 -6.29 -0.36 1.3e-9 Gambling; CESC cis rs7615952 0.611 rs35321002 chr3:125612065 G/C cg05084668 chr3:125655381 ALG1L -0.6 -6.54 -0.37 3.1e-10 Blood pressure (smoking interaction); CESC cis rs4835473 0.831 rs2667353 chr4:144881615 G/C cg25736465 chr4:144833511 NA 0.41 6.05 0.35 4.79e-9 Immature fraction of reticulocytes; CESC trans rs6499188 0.522 rs8046299 chr16:68672346 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.64 0.42 3.93e-13 Ulcerative colitis; CESC cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg20476274 chr7:133979776 SLC35B4 0.58 7.59 0.42 5.33e-13 Mean platelet volume; CESC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg23758822 chr17:41437982 NA 1.01 15.21 0.68 5.44e-38 Menopause (age at onset); CESC cis rs6732160 0.619 rs12105975 chr2:73406049 T/A cg01422370 chr2:73384389 NA 0.42 6.77 0.38 8.44e-11 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20974885 chr3:183966734 ALG3;ECE2 0.77 8.69 0.47 3.73e-16 Gut microbiome composition (summer); CESC cis rs6580649 1.000 rs10783227 chr12:48400617 C/T cg24011408 chr12:48396354 COL2A1 0.4 5.17 0.3 4.63e-7 Lung cancer; CESC cis rs6831352 0.918 rs13110176 chr4:100062430 C/T cg12011299 chr4:100065546 ADH4 0.56 6.34 0.36 9.9e-10 Alcohol dependence; CESC cis rs116095464 0.558 rs62347677 chr5:227453 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.71 -0.47 3.44e-16 Breast cancer; CESC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg11494091 chr17:61959527 GH2 0.73 12.48 0.61 2.02e-28 Prudent dietary pattern; CESC cis rs72627123 0.867 rs17094448 chr14:74440119 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.76 5.04 0.3 8.57e-7 Morning vs. evening chronotype; CESC cis rs1707322 1.000 rs6676982 chr1:46275401 A/T cg05343316 chr1:45956843 TESK2 0.44 5.53 0.32 7.85e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3820068 0.581 rs6692489 chr1:15928517 A/G cg16988262 chr1:15930761 NA 0.33 5.35 0.31 1.89e-7 Systolic blood pressure; CESC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 7.22 0.41 5.43e-12 Lymphocyte counts; CESC trans rs7615952 0.673 rs7632557 chr3:125634881 G/C cg07211511 chr3:129823064 LOC729375 -1.1 -13.65 -0.64 1.67e-32 Blood pressure (smoking interaction); CESC cis rs9549260 0.709 rs2721072 chr13:41144919 G/A cg21288729 chr13:41239152 FOXO1 0.67 8.49 0.46 1.54e-15 Red blood cell count; CESC cis rs7116495 0.609 rs949326 chr11:71730306 A/G cg26138937 chr11:71823887 C11orf51 1.04 7.01 0.4 1.96e-11 Severe influenza A (H1N1) infection; CESC cis rs9287719 0.967 rs7566767 chr2:10754663 T/C cg02196655 chr2:10830764 NOL10 -0.37 -5.58 -0.32 5.98e-8 Prostate cancer; CESC trans rs11098499 0.754 rs11724409 chr4:120252361 A/G cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs7580658 0.680 rs2069931 chr2:128185569 C/T cg10021288 chr2:128175891 PROC -0.41 -6.14 -0.35 2.94e-9 Protein C levels; CESC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.07 -0.3 7.42e-7 Menopause (age at onset); CESC cis rs116979167 0.630 rs56230603 chr7:105165268 A/G cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg18758796 chr5:131593413 PDLIM4 0.45 6.31 0.36 1.14e-9 Breast cancer; CESC cis rs9549367 0.789 rs9549699 chr13:113878263 T/A cg18105134 chr13:113819100 PROZ -0.66 -8.24 -0.45 8.04e-15 Platelet distribution width; CESC cis rs7584330 0.868 rs58057291 chr2:238395479 T/A cg14458575 chr2:238380390 NA 0.75 10.47 0.54 1.05e-21 Prostate cancer; CESC trans rs9467711 0.606 rs9366653 chr6:26354247 G/A cg06606381 chr12:133084897 FBRSL1 -0.77 -7.0 -0.4 2.04e-11 Autism spectrum disorder or schizophrenia; CESC trans rs10895547 0.527 rs566033 chr11:103790856 A/G cg23613023 chr12:115353932 NA -0.38 -6.16 -0.35 2.7e-9 LDL cholesterol; CESC cis rs2066819 1.000 rs11171803 chr12:56718422 T/C cg26734620 chr12:56694298 CS 1.03 6.25 0.36 1.65e-9 Psoriasis vulgaris; CESC cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg03433033 chr1:76189801 ACADM 0.71 9.78 0.52 1.68e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg21724239 chr8:58056113 NA 0.55 5.6 0.33 5.43e-8 Developmental language disorder (linguistic errors); CESC cis rs1707322 0.686 rs2050376 chr1:46078630 C/T cg06784218 chr1:46089804 CCDC17 0.42 7.43 0.42 1.52e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs62103177 0.733 rs62096747 chr18:77619568 A/G cg05926928 chr17:57297772 GDPD1 1.2 10.71 0.55 1.82e-22 Opioid sensitivity; CESC cis rs9790314 1.000 rs336577 chr3:161066294 C/T cg03342759 chr3:160939853 NMD3 -0.49 -6.43 -0.37 6.04e-10 Morning vs. evening chronotype; CESC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.57 -0.32 6.1e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2979489 0.891 rs2915590 chr8:30393334 A/G cg26383811 chr8:30366931 RBPMS -0.78 -9.72 -0.51 2.78e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs6121246 0.528 rs6060252 chr20:30191084 A/G cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs400736 0.562 rs7551900 chr1:8178526 A/C cg25007680 chr1:8021821 PARK7 -0.55 -6.86 -0.39 4.91e-11 Response to antidepressants and depression; CESC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg18099408 chr3:52552593 STAB1 -0.32 -5.15 -0.3 5.11e-7 Bipolar disorder; CESC cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg06212747 chr3:49208901 KLHDC8B 0.66 8.81 0.48 1.65e-16 Parkinson's disease; CESC cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg22875332 chr1:76189707 ACADM 0.64 7.7 0.43 2.76e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1580019 0.961 rs11765387 chr7:32494790 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.72 10.07 0.53 2.04e-20 Cognitive ability; CESC cis rs8014204 0.836 rs888413 chr14:75267396 C/T cg11812906 chr14:75593930 NEK9 0.42 5.14 0.3 5.35e-7 Caffeine consumption; CESC cis rs1847505 0.609 rs9538998 chr13:61571160 A/G cg25164009 chr13:61490935 NA -0.4 -5.41 -0.32 1.4e-7 Polychlorinated biphenyl levels; CESC cis rs3733585 0.605 rs56178126 chr4:10123581 C/T cg02734326 chr4:10020555 SLC2A9 -0.38 -5.13 -0.3 5.48e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9649465 0.688 rs34967330 chr7:123318560 A/C cg04330084 chr7:123175371 IQUB -0.39 -5.26 -0.31 2.95e-7 Migraine; CESC cis rs10838687 0.800 rs10838689 chr11:47334524 C/T cg25783544 chr11:47291846 MADD 0.5 5.39 0.31 1.55e-7 Proinsulin levels; CESC cis rs2282802 0.585 rs2189659 chr5:139697220 C/A cg26211634 chr5:139558579 C5orf32 -0.46 -6.6 -0.38 2.21e-10 Intelligence (multi-trait analysis); CESC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.89 0.52 7.53e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg03388025 chr16:89894329 SPIRE2 0.39 7.39 0.41 1.94e-12 Vitiligo; CESC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg04166393 chr7:2884313 GNA12 0.63 8.01 0.44 3.75e-14 Height; CESC cis rs13256369 0.802 rs35382339 chr8:8559255 G/A cg00074818 chr8:8560427 CLDN23 0.37 5.18 0.3 4.44e-7 Obesity-related traits; CESC cis rs7116495 0.609 rs7942626 chr11:71703849 G/A cg26138937 chr11:71823887 C11orf51 -1.22 -8.09 -0.45 2.15e-14 Severe influenza A (H1N1) infection; CESC cis rs2204008 0.537 rs11170128 chr12:38006632 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.77 0.38 8.14e-11 Bladder cancer; CESC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg18016565 chr1:150552671 MCL1 0.34 5.29 0.31 2.53e-7 Melanoma; CESC cis rs6500395 1.000 rs8052073 chr16:48682696 T/C cg04672837 chr16:48644449 N4BP1 0.51 6.36 0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9858542 0.953 rs1801143 chr3:49570200 C/T cg07274523 chr3:49395745 GPX1 0.66 8.17 0.45 1.23e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6500395 0.775 rs7185541 chr16:48664681 A/G cg04672837 chr16:48644449 N4BP1 0.49 6.27 0.36 1.46e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2191566 0.664 rs7251083 chr19:44551866 G/T cg20607764 chr19:44506953 ZNF230 -0.44 -5.64 -0.33 4.34e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.85 0.34 1.46e-8 Bipolar disorder; CESC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg26314531 chr2:26401878 FAM59B -0.61 -6.91 -0.39 3.66e-11 Gut microbiome composition (summer); CESC cis rs5769765 0.908 rs2319464 chr22:50265777 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.31 0.31 2.35e-7 Schizophrenia; CESC cis rs8092503 0.951 rs12457769 chr18:52499801 T/G cg12377874 chr18:52495404 RAB27B 0.37 6.11 0.35 3.62e-9 Childhood body mass index; CESC cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs6088590 0.561 rs3891369 chr20:33161127 C/T cg06115741 chr20:33292138 TP53INP2 0.52 6.74 0.38 1e-10 Coronary artery disease; CESC cis rs12479064 0.694 rs11896520 chr2:99995517 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -7.34 -0.41 2.6e-12 Chronic sinus infection; CESC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg14664628 chr15:75095509 CSK -0.54 -7.22 -0.41 5.37e-12 Breast cancer; CESC cis rs8017423 0.647 rs11626821 chr14:90824945 A/G cg14092571 chr14:90743983 NA 0.44 6.77 0.38 8.12e-11 Mortality in heart failure; CESC cis rs896854 0.517 rs1011796 chr8:95951273 A/G cg16049864 chr8:95962084 TP53INP1 0.54 7.6 0.42 4.98e-13 Type 2 diabetes; CESC cis rs7605827 0.930 rs4668445 chr2:15515838 C/T cg19274914 chr2:15703543 NA 0.32 5.7 0.33 3.17e-8 Educational attainment (years of education); CESC cis rs7560272 0.501 rs17350188 chr2:73964842 C/G cg20560298 chr2:73613845 ALMS1 -0.44 -5.95 -0.34 8.45e-9 Schizophrenia; CESC cis rs1153858 0.723 rs11855527 chr15:45606685 G/A cg21132104 chr15:45694354 SPATA5L1 -0.72 -9.29 -0.5 5.8e-18 Homoarginine levels; CESC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg08470875 chr2:26401718 FAM59B -0.76 -8.06 -0.44 2.69e-14 Gut microbiome composition (summer); CESC cis rs17125944 0.615 rs2025632 chr14:53294319 T/C cg00686598 chr14:53173677 PSMC6 -0.69 -5.95 -0.34 8.3e-9 Alzheimer's disease (late onset); CESC cis rs941873 0.868 rs2233718 chr10:81108956 A/G cg11057378 chr10:81107060 PPIF 0.31 5.05 0.3 8.43e-7 Height; CESC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg01416388 chr22:39784598 NA -0.61 -7.09 -0.4 1.25e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7089973 0.584 rs4752255 chr10:116576790 C/T cg25233709 chr10:116636983 FAM160B1 0.35 5.55 0.32 6.87e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9457247 0.663 rs6456143 chr6:167415440 C/A cg25258033 chr6:167368657 RNASET2 0.37 5.39 0.31 1.56e-7 Crohn's disease; CESC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg00750074 chr16:89608354 SPG7 -0.43 -6.18 -0.35 2.41e-9 Multiple myeloma (IgH translocation); CESC cis rs9929218 1.000 rs13334294 chr16:68809278 A/C cg02972257 chr16:68554789 NA 0.43 5.12 0.3 5.89e-7 Colorectal cancer; CESC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.26 0.36 1.57e-9 Menopause (age at onset); CESC cis rs3106136 0.967 rs17310266 chr4:95177051 T/C cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.72 -0.38 1.14e-10 Capecitabine sensitivity; CESC cis rs2404602 0.735 rs56246286 chr15:76690731 C/T cg23625390 chr15:77176239 SCAPER -0.43 -5.94 -0.34 8.72e-9 Blood metabolite levels; CESC trans rs9929218 1.000 rs67359183 chr16:68814204 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.64 -8.36 -0.46 3.57e-15 Colorectal cancer; CESC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg22903471 chr2:27725779 GCKR -0.56 -8.05 -0.44 2.81e-14 Menopause (age at onset); CESC cis rs7264396 0.836 rs6058282 chr20:34212590 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.33 -0.57 1.56e-24 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01083584 chr19:14629193 DNAJB1 0.53 6.34 0.36 1.01e-9 Gut microbiome composition (summer); CESC trans rs6021270 0.850 rs1987430 chr20:50134174 G/A cg05339727 chr2:165812079 SLC38A11 -0.79 -6.11 -0.35 3.45e-9 Self-reported allergy; CESC cis rs863345 0.967 rs863355 chr1:158542595 T/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.36 -0.36 8.9e-10 Pneumococcal bacteremia; CESC cis rs34779708 0.966 rs12775548 chr10:35479504 G/T cg03585969 chr10:35415529 CREM 0.71 9.19 0.49 1.21e-17 Inflammatory bowel disease;Crohn's disease; CESC cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg08069147 chr6:88032118 GJB7;C6orf162 0.76 11.09 0.56 9.87e-24 Monocyte percentage of white cells; CESC trans rs66573146 1.000 rs56178503 chr4:6961748 C/T cg07817883 chr1:32538562 TMEM39B 1.51 9.21 0.49 1.06e-17 Granulocyte percentage of myeloid white cells; CESC cis rs7084402 0.902 rs1593670 chr10:60300766 C/G cg07615347 chr10:60278583 BICC1 0.6 9.46 0.5 1.77e-18 Refractive error; CESC cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.52 6.3 0.36 1.26e-9 Breast cancer; CESC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg10578991 chr7:12443926 VWDE -0.45 -5.11 -0.3 6.15e-7 Coronary artery disease; CESC cis rs12313068 0.600 rs7136207 chr12:110491487 T/C cg12870014 chr12:110450643 ANKRD13A 0.86 9.68 0.51 3.61e-19 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20980112 chr1:155108432 RAG1AP1 0.62 7.06 0.4 1.45e-11 Gut microbiome composition (summer); CESC trans rs17508449 0.819 rs4839332 chr1:114162191 G/T cg23028848 chr11:57092561 TNKS1BP1 -0.82 -6.49 -0.37 4.21e-10 Leprosy; CESC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg11764359 chr7:65958608 NA -0.94 -15.34 -0.69 1.97e-38 Aortic root size; CESC cis rs35955747 0.902 rs5997919 chr22:31623442 A/G cg25791279 chr22:32026902 PISD -0.48 -5.75 -0.33 2.44e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs959260 1.000 rs7216423 chr17:73365671 T/C cg12999837 chr17:73267436 MIF4GD -0.47 -5.46 -0.32 1.1e-7 Systemic lupus erythematosus; CESC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg14703610 chr5:56206110 C5orf35 0.43 5.38 0.31 1.62e-7 Coronary artery disease; CESC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg11644478 chr21:40555479 PSMG1 1.03 16.69 0.72 3.03e-43 Cognitive function; CESC cis rs2204008 0.805 rs11179579 chr12:38213957 A/C cg26384229 chr12:38710491 ALG10B 0.71 10.3 0.53 3.96e-21 Bladder cancer; CESC cis rs854765 0.583 rs9635697 chr17:17870394 T/A cg09796270 chr17:17721594 SREBF1 0.45 6.17 0.35 2.61e-9 Total body bone mineral density; CESC cis rs2439831 0.764 rs12324584 chr15:43683446 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.89 0.56 4.69e-23 Lung cancer in ever smokers; CESC trans rs1814175 0.645 rs7103554 chr11:50027612 G/A cg03929089 chr4:120376271 NA -0.9 -14.7 -0.67 3.47e-36 Height; CESC cis rs4975709 0.838 rs4975752 chr5:1880588 A/C cg17650747 chr5:1873721 NA 0.39 5.24 0.31 3.21e-7 Cardiovascular disease risk factors; CESC cis rs7312774 0.618 rs12316476 chr12:107343326 C/G cg16260113 chr12:107380972 MTERFD3 0.81 7.42 0.41 1.55e-12 Severe influenza A (H1N1) infection; CESC cis rs3126085 0.935 rs11204934 chr1:152176848 C/A cg03465714 chr1:152285911 FLG 0.47 5.55 0.32 6.93e-8 Atopic dermatitis; CESC trans rs1557351 0.569 rs2027701 chr18:54725195 C/T cg11433624 chr6:7146702 RREB1 -0.36 -6.06 -0.35 4.54e-9 Multiple sclerosis (age of onset); CESC cis rs4704187 0.687 rs6879894 chr5:74498164 C/A cg03227963 chr5:74354835 NA 0.28 5.18 0.3 4.33e-7 Response to amphetamines; CESC cis rs1009181 0.585 rs9379827 chr6:26153335 G/T cg17691542 chr6:26056736 HIST1H1C 0.51 5.24 0.31 3.36e-7 Childhood ear infection; CESC cis rs7532866 0.885 rs7517224 chr1:26731029 A/G cg17456097 chr1:26900765 RPS6KA1 -0.47 -6.04 -0.35 5.23e-9 Height; CESC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.69 -7.83 -0.43 1.19e-13 Gut microbiome composition (summer); CESC cis rs12477438 0.520 rs11692699 chr2:99730657 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.61 0.69 2.15e-39 Chronic sinus infection; CESC cis rs116095464 0.510 rs10057501 chr5:239545 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.66 -0.47 4.75e-16 Breast cancer; CESC cis rs9611565 0.643 rs202634 chr22:41809623 A/G cg06634786 chr22:41940651 POLR3H 0.73 7.46 0.42 1.23e-12 Vitiligo; CESC cis rs9303401 0.659 rs56162835 chr17:56687315 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.04 13.0 0.62 3.27e-30 Cognitive test performance; CESC trans rs9858542 1.000 rs9836291 chr3:49697459 G/A cg21659725 chr3:3221576 CRBN -0.54 -6.63 -0.38 1.89e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4835473 0.868 rs66634585 chr4:144655761 C/G cg25736465 chr4:144833511 NA -0.33 -5.23 -0.31 3.44e-7 Immature fraction of reticulocytes; CESC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg05368731 chr17:41323189 NBR1 0.79 10.91 0.56 4.06e-23 Menopause (age at onset); CESC cis rs6088590 1.000 rs6120705 chr20:33313740 T/C cg06115741 chr20:33292138 TP53INP2 0.59 7.32 0.41 2.95e-12 Coronary artery disease; CESC trans rs3780486 0.801 rs3780495 chr9:33125942 A/C cg04842962 chr6:43655489 MRPS18A 1.0 19.11 0.76 8.81e-52 IgG glycosylation; CESC cis rs3820068 0.532 rs74057713 chr1:15944620 G/C cg13390004 chr1:15929781 NA 0.36 5.92 0.34 9.92e-9 Systolic blood pressure; CESC cis rs826838 0.868 rs864324 chr12:39122853 A/G cg13010199 chr12:38710504 ALG10B 0.41 5.65 0.33 4.04e-8 Heart rate; CESC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg18404041 chr3:52824283 ITIH1 -0.41 -6.79 -0.38 7.34e-11 Bipolar disorder; CESC cis rs2108225 0.900 rs7805114 chr7:107450033 G/T cg18560240 chr7:107437656 SLC26A3 0.39 5.34 0.31 2.05e-7 Ulcerative colitis; CESC cis rs9815354 0.680 rs73073250 chr3:42016559 G/T cg03022575 chr3:42003672 ULK4 0.74 6.64 0.38 1.79e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs2979489 0.891 rs4449748 chr8:30304402 A/G cg26383811 chr8:30366931 RBPMS 0.82 9.6 0.51 6.26e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs9894429 1.000 rs9748176 chr17:79584043 C/G cg13777783 chr17:79615861 NA -0.35 -5.81 -0.34 1.83e-8 Eye color traits; CESC cis rs826838 0.935 rs1160162 chr12:38959795 G/A cg13010199 chr12:38710504 ALG10B 0.58 8.14 0.45 1.56e-14 Heart rate; CESC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs8018808 0.902 rs176773 chr14:77882456 C/T cg20045696 chr14:77926864 AHSA1 0.42 5.84 0.34 1.56e-8 Myeloid white cell count; CESC cis rs116988415 0.584 rs74331120 chr14:65244595 G/A cg25083366 chr14:65239357 SPTB 0.75 5.47 0.32 1.02e-7 Daytime sleep phenotypes; CESC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg19346786 chr7:2764209 NA -0.47 -6.76 -0.38 9.02e-11 Height; CESC trans rs9784649 0.771 rs72755810 chr5:25039139 A/C cg08600765 chr20:34638493 LOC647979 -0.55 -6.27 -0.36 1.48e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26561342 chr1:45241260 SNORD55;RPS8;SNORD46 0.53 6.57 0.37 2.71e-10 Gut microbiome composition (summer); CESC cis rs5167 0.504 rs3760629 chr19:45458146 A/C cg20090143 chr19:45452003 APOC2 0.33 5.82 0.34 1.66e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11259409 chr11:1331124 LOC255512;TOLLIP 0.59 6.99 0.39 2.22e-11 Gut microbiome composition (summer); CESC cis rs8099014 0.814 rs4245272 chr18:56115145 T/A cg19312305 chr18:56117016 MIR122 -0.26 -5.21 -0.3 3.83e-7 Platelet count; CESC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg16325326 chr1:53192061 ZYG11B 0.53 7.5 0.42 9.67e-13 Monocyte count; CESC cis rs208515 0.525 rs10755508 chr6:66675790 T/C cg07460842 chr6:66804631 NA 0.85 10.63 0.55 3.24e-22 Exhaled nitric oxide levels; CESC cis rs950169 1.000 rs35658069 chr15:84780146 C/T cg17507749 chr15:85114479 UBE2QP1 0.6 6.61 0.38 2.08e-10 Schizophrenia; CESC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg02807482 chr3:125708958 NA -0.4 -5.2 -0.3 3.94e-7 Blood pressure (smoking interaction); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg09265274 chr17:48585635 MYCBPAP -0.45 -6.2 -0.36 2.19e-9 Bronchopulmonary dysplasia; CESC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg20307385 chr11:47447363 PSMC3 0.62 7.61 0.42 4.7e-13 Subjective well-being; CESC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg24531977 chr5:56204891 C5orf35 0.87 11.43 0.57 7.36e-25 Initial pursuit acceleration; CESC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg26850624 chr5:429559 AHRR -0.5 -6.67 -0.38 1.52e-10 Cystic fibrosis severity; CESC cis rs11997175 0.574 rs7001404 chr8:33645219 G/A ch.8.33884649F chr8:33765107 NA 0.65 8.33 0.46 4.47e-15 Body mass index; CESC cis rs2708240 0.689 rs2710114 chr7:147598021 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.66 -0.33 3.93e-8 QT interval (drug interaction); CESC cis rs3888647 0.561 rs4758617 chr11:2995185 T/A cg08508325 chr11:3079039 CARS -0.5 -9.29 -0.5 5.75e-18 Type 2 diabetes; CESC cis rs9486719 0.802 rs2983896 chr6:97029871 G/A cg06623918 chr6:96969491 KIAA0776 -0.9 -10.79 -0.55 9.98e-23 Migraine;Coronary artery disease; CESC cis rs9399135 0.660 rs4472368 chr6:135274232 A/G cg22676075 chr6:135203613 NA 0.48 6.5 0.37 4.04e-10 Red blood cell count; CESC cis rs9911578 1.000 rs7215808 chr17:56940742 G/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.95 -0.39 2.8e-11 Intelligence (multi-trait analysis); CESC cis rs4481887 0.830 rs4916126 chr1:248466604 G/A cg00666640 chr1:248458726 OR2T12 0.39 6.37 0.36 8.47e-10 Common traits (Other); CESC cis rs7259376 0.902 rs4932763 chr19:22603922 C/A cg02657401 chr19:22469223 NA 0.26 5.07 0.3 7.61e-7 Menopause (age at onset); CESC cis rs4253772 0.550 rs9615951 chr22:46728056 C/A cg24881330 chr22:46731750 TRMU 0.78 6.4 0.37 6.94e-10 LDL cholesterol;Cholesterol, total; CESC cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg25554036 chr4:6271136 WFS1 0.51 8.34 0.46 4.21e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7264396 0.635 rs6060720 chr20:34548336 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.35 -0.54 2.7e-21 Total cholesterol levels; CESC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.88 0.39 4.21e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12477438 0.520 rs2516829 chr2:99773201 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.91 15.51 0.69 4.65e-39 Chronic sinus infection; CESC cis rs4535700 0.501 rs10227764 chr7:56012422 A/C cg09872392 chr7:56161020 PHKG1 0.4 5.78 0.33 2.1e-8 Macular telangiectasia type 2; CESC cis rs919433 0.783 rs55725278 chr2:198238223 C/T cg10820045 chr2:198174542 NA 0.41 5.98 0.34 7.19e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9325144 0.541 rs7303395 chr12:38664124 C/T cg26384229 chr12:38710491 ALG10B -0.6 -8.49 -0.46 1.45e-15 Morning vs. evening chronotype; CESC cis rs4588572 0.644 rs6873144 chr5:77741784 C/T cg11547950 chr5:77652471 NA -0.4 -5.56 -0.32 6.42e-8 Triglycerides; CESC cis rs372883 0.600 rs1153277 chr21:30666867 A/T cg24692254 chr21:30365293 RNF160 -0.59 -7.61 -0.42 4.74e-13 Pancreatic cancer; CESC cis rs12325245 0.536 rs71375919 chr16:58547522 C/T cg02549819 chr16:58548995 SETD6 0.95 6.25 0.36 1.67e-9 Schizophrenia; CESC cis rs72772090 0.539 rs72773917 chr5:96111302 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.03 -0.3 8.86e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg08859206 chr1:53392774 SCP2 0.63 9.27 0.49 6.72e-18 Monocyte count; CESC cis rs12540874 0.698 rs3807566 chr7:50564204 G/T cg18232548 chr7:50535776 DDC -0.42 -5.89 -0.34 1.16e-8 Systemic sclerosis; CESC cis rs12887734 0.546 rs4906376 chr14:104272165 A/C cg08213375 chr14:104286397 PPP1R13B 0.38 6.41 0.37 6.71e-10 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs2075371 0.637 rs13245165 chr7:133951492 A/T cg20476274 chr7:133979776 SLC35B4 0.62 8.9 0.48 8.88e-17 Mean platelet volume; CESC cis rs365132 0.875 rs4976665 chr5:176352736 C/T cg16309518 chr5:176445507 NA -0.37 -5.33 -0.31 2.09e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs6088590 0.523 rs6059913 chr20:33143288 G/A cg08999081 chr20:33150536 PIGU 0.7 12.47 0.61 2.17e-28 Coronary artery disease; CESC cis rs523522 0.962 rs3742052 chr12:120966921 A/G cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg19052272 chr2:3704530 ALLC -0.79 -8.83 -0.48 1.5e-16 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs7267979 0.565 rs6107060 chr20:25592476 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.7 11.68 0.58 1.05e-25 Liver enzyme levels (alkaline phosphatase); CESC trans rs10517270 0.744 rs10028228 chr4:33212652 A/G cg20709895 chr11:43965598 NA 0.62 6.45 0.37 5.4e-10 Alzheimer's disease (age of onset); CESC cis rs738322 1.000 rs4382 chr22:38570842 T/C cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC trans rs11098499 0.954 rs3733523 chr4:120423719 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.78 0.51 1.7e-19 Corneal astigmatism; CESC cis rs2519796 0.531 rs2519804 chr9:136805739 G/A cg13751417 chr9:136814406 VAV2 -0.43 -5.67 -0.33 3.79e-8 Hematocrit;Hemoglobin concentration; CESC trans rs877282 0.945 rs17293517 chr10:778770 C/T cg22713356 chr15:30763199 NA 1.32 13.38 0.63 1.51e-31 Uric acid levels; CESC cis rs12121840 0.790 rs6657863 chr1:165546671 G/A cg16553119 chr1:165599451 MGST3 -0.43 -5.55 -0.32 6.91e-8 Interleukin-1-receptor antagonist levels; CESC cis rs7512552 0.839 rs11587116 chr1:150451898 A/T cg15654264 chr1:150340011 RPRD2 0.39 5.2 0.3 3.98e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs9929218 0.954 rs4552018 chr16:68822854 T/G cg02972257 chr16:68554789 NA 0.45 5.39 0.31 1.58e-7 Colorectal cancer; CESC cis rs2011503 0.941 rs56044734 chr19:19366927 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.43 0.32 1.3e-7 Bipolar disorder; CESC cis rs7084402 0.967 rs1649025 chr10:60281584 C/G cg07615347 chr10:60278583 BICC1 -0.6 -9.49 -0.5 1.43e-18 Refractive error; CESC cis rs3806843 0.735 rs801167 chr5:140081423 A/G cg26395211 chr5:140044315 WDR55 -0.45 -5.67 -0.33 3.74e-8 Depressive symptoms (multi-trait analysis); CESC cis rs7259376 0.869 rs10402396 chr19:22601809 G/C cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.79e-7 Menopause (age at onset); CESC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg00166722 chr3:10149974 C3orf24 0.48 5.97 0.34 7.76e-9 Alzheimer's disease; CESC cis rs7937682 0.961 rs11828343 chr11:111491322 A/G cg22437258 chr11:111473054 SIK2 -0.69 -8.26 -0.45 7.19e-15 Primary sclerosing cholangitis; CESC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2011503 1.000 rs75453386 chr19:19637781 C/T cg11584989 chr19:19387371 SF4 0.61 7.03 0.4 1.79e-11 Bipolar disorder; CESC cis rs60871478 0.945 rs62432254 chr7:804175 C/T cg27478167 chr7:817139 HEATR2 -0.49 -5.88 -0.34 1.23e-8 Cerebrospinal P-tau181p levels; CESC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg06420487 chr17:61919686 SMARCD2 0.47 5.59 0.32 5.64e-8 Height; CESC cis rs2228479 0.717 rs2074904 chr16:89811546 A/G cg06558623 chr16:89946397 TCF25 1.19 9.55 0.51 8.99e-19 Skin colour saturation; CESC cis rs977987 0.872 rs10781976 chr16:75314838 G/T cg03315344 chr16:75512273 CHST6 0.38 5.41 0.32 1.39e-7 Dupuytren's disease; CESC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg18225595 chr11:63971243 STIP1 0.52 5.19 0.3 4.19e-7 Mean platelet volume; CESC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg22823121 chr1:150693482 HORMAD1 0.47 6.64 0.38 1.73e-10 Melanoma; CESC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC cis rs3733585 0.673 rs6836706 chr4:9964251 T/A cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs801193 0.967 rs2707853 chr7:66214010 G/A cg26939375 chr7:64535504 NA 0.64 8.67 0.47 4.31e-16 Aortic root size; CESC cis rs962856 0.964 rs5022017 chr2:67619177 G/A cg09028215 chr2:67624308 ETAA1 -0.4 -5.33 -0.31 2.07e-7 Pancreatic cancer; CESC cis rs9611565 0.729 rs2413646 chr22:41906325 C/T cg06634786 chr22:41940651 POLR3H -0.7 -7.13 -0.4 9.69e-12 Vitiligo; CESC cis rs7084402 0.967 rs1658467 chr10:60295316 A/G cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.35e-18 Refractive error; CESC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg18876405 chr7:65276391 NA 0.49 6.67 0.38 1.46e-10 Aortic root size; CESC cis rs4523957 0.583 rs2760738 chr17:2024600 A/G cg16513277 chr17:2031491 SMG6 -0.71 -10.08 -0.53 1.96e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg06221963 chr1:154839813 KCNN3 -0.66 -11.23 -0.57 3.52e-24 Prostate cancer; CESC cis rs10242455 0.717 rs2741872 chr7:99339776 A/T cg07715041 chr7:99302981 CYP3A7 -0.45 -5.32 -0.31 2.25e-7 Blood metabolite levels; CESC cis rs754466 0.651 rs11002316 chr10:79617511 C/G cg17075019 chr10:79541650 NA -0.87 -13.72 -0.64 1.01e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs875971 0.564 rs313804 chr7:65514622 A/G cg18876405 chr7:65276391 NA 0.56 7.47 0.42 1.15e-12 Aortic root size; CESC trans rs2391518 0.639 rs2952860 chr4:130782065 A/G cg04981619 chr2:43328122 NA 0.38 6.0 0.35 6.59e-9 Body mass index; CESC cis rs9309473 0.519 rs7606947 chr2:73909818 C/T cg20560298 chr2:73613845 ALMS1 -0.5 -7.03 -0.4 1.77e-11 Metabolite levels; CESC cis rs7116495 0.609 rs595062 chr11:71809635 C/T cg10381502 chr11:71823885 C11orf51 1.05 6.51 0.37 3.78e-10 Severe influenza A (H1N1) infection; CESC cis rs11098499 0.863 rs3822190 chr4:120428098 G/A cg09307838 chr4:120376055 NA 0.95 13.17 0.63 8.54e-31 Corneal astigmatism; CESC cis rs7666738 0.830 rs880470 chr4:98922522 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7937682 0.587 rs571594 chr11:111359334 A/G cg22437258 chr11:111473054 SIK2 -0.44 -5.52 -0.32 8.22e-8 Primary sclerosing cholangitis; CESC trans rs1814175 0.645 rs28839231 chr11:50044292 G/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.71 -0.75 2.23e-50 Height; CESC cis rs12477438 0.501 rs12613624 chr2:99732741 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.8 -12.74 -0.62 2.5e-29 Chronic sinus infection; CESC cis rs4474465 0.736 rs10899542 chr11:78246572 T/G cg27205649 chr11:78285834 NARS2 0.44 5.33 0.31 2.12e-7 Alzheimer's disease (survival time); CESC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg22823121 chr1:150693482 HORMAD1 0.36 5.12 0.3 5.88e-7 Melanoma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12129596 chr19:55770037 SAPS1 -0.45 -6.58 -0.37 2.51e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg24829409 chr8:58192753 C8orf71 -0.67 -8.18 -0.45 1.19e-14 Developmental language disorder (linguistic errors); CESC cis rs9303401 0.659 rs34351230 chr17:56782555 C/A cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC cis rs10191773 0.589 rs6761440 chr2:112959193 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.74 -7.2 -0.4 6.14e-12 Yeast infection; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26918957 chr8:22926800 TNFRSF10B -0.45 -6.24 -0.36 1.7e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs854765 0.583 rs7213225 chr17:17869111 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.22 0.45 9.43e-15 Total body bone mineral density; CESC cis rs9296736 0.922 rs625899 chr6:53957588 C/T cg04374786 chr6:53939321 C6orf142 -0.32 -5.19 -0.3 4.16e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs116095464 0.558 rs6869925 chr5:264036 A/G cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.51e-10 Breast cancer; CESC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg16145915 chr7:1198662 ZFAND2A -0.49 -6.15 -0.35 2.92e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg04025307 chr7:1156635 C7orf50 0.45 7.29 0.41 3.56e-12 Longevity;Endometriosis; CESC cis rs6500395 0.925 rs12920170 chr16:48701530 A/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs62229266 0.804 rs2835259 chr21:37425302 T/C cg08632701 chr21:37451849 NA -0.38 -5.2 -0.3 3.96e-7 Mitral valve prolapse; CESC cis rs2790457 0.958 rs2772432 chr10:28894295 G/A cg04045419 chr10:28823091 WAC -0.43 -5.16 -0.3 4.76e-7 Multiple myeloma; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg06772157 chr7:100728711 TRIM56 -0.53 -6.24 -0.36 1.68e-9 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16931877 chr3:32726605 CNOT10 0.64 7.16 0.4 7.98e-12 Gut microbiome composition (summer); CESC cis rs6502050 0.626 rs11868521 chr17:80100195 T/G cg23985595 chr17:80112537 CCDC57 0.36 5.18 0.3 4.33e-7 Life satisfaction; CESC cis rs1055129 0.560 rs9891076 chr17:73911715 C/T cg02678768 chr17:74002944 EVPL 0.42 5.93 0.34 9.62e-9 White matter hyperintensity burden; CESC cis rs10870270 0.956 rs10870281 chr10:133762642 G/A cg17892150 chr10:133769511 PPP2R2D -0.87 -12.75 -0.62 2.25e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09882061 chr5:175874675 FAF2 0.59 6.56 0.37 2.75e-10 Gut microbiome composition (summer); CESC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg18758796 chr5:131593413 PDLIM4 -0.41 -5.74 -0.33 2.61e-8 Breast cancer; CESC cis rs17253792 0.822 rs113692713 chr14:56087424 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs5753037 0.653 rs140133 chr22:30152522 G/C cg01021169 chr22:30184971 ASCC2 -0.44 -6.21 -0.36 2.09e-9 Type 1 diabetes; CESC cis rs7116495 0.737 rs661290 chr11:71766014 A/G cg26138937 chr11:71823887 C11orf51 -1.18 -7.09 -0.4 1.25e-11 Severe influenza A (H1N1) infection; CESC cis rs6466055 0.720 rs35757884 chr7:105020534 G/T cg04380332 chr7:105027541 SRPK2 -0.42 -5.36 -0.31 1.81e-7 Schizophrenia; CESC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg19622623 chr12:86230825 RASSF9 -0.48 -6.11 -0.35 3.64e-9 Major depressive disorder; CESC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg12963246 chr6:28129442 ZNF389 0.49 6.34 0.36 9.71e-10 Parkinson's disease; CESC cis rs9291683 0.588 rs2240724 chr4:10021290 G/C cg11266682 chr4:10021025 SLC2A9 0.71 14.8 0.67 1.56e-36 Bone mineral density; CESC cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg27129171 chr3:47204927 SETD2 0.67 9.93 0.52 5.88e-20 Colorectal cancer; CESC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg19770292 chr5:1868693 NA 0.3 5.18 0.3 4.47e-7 Cardiovascular disease risk factors; CESC cis rs4835473 0.932 rs6813011 chr4:144835649 G/T cg25736465 chr4:144833511 NA 0.41 6.21 0.36 2.09e-9 Immature fraction of reticulocytes; CESC cis rs5417 0.788 rs2654185 chr17:7183362 G/T cg25256661 chr17:7137939 DVL2 0.53 7.3 0.41 3.27e-12 Diastolic blood pressure; CESC cis rs3106136 0.967 rs4693377 chr4:95157256 G/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.98 -0.39 2.33e-11 Capecitabine sensitivity; CESC cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg04450456 chr4:17643702 FAM184B 0.38 5.44 0.32 1.2e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg22535103 chr8:58192502 C8orf71 -1.06 -13.14 -0.63 1.04e-30 Developmental language disorder (linguistic errors); CESC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg22920501 chr2:26401640 FAM59B -0.67 -8.09 -0.44 2.22e-14 Gut microbiome composition (summer); CESC cis rs1707322 0.686 rs1541131 chr1:46084934 G/A cg06784218 chr1:46089804 CCDC17 -0.41 -7.15 -0.4 8.63e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2908835 0.705 rs35428220 chr12:11644192 G/T cg09915232 chr8:1879280 ARHGEF10 -0.64 -6.26 -0.36 1.52e-9 Information processing speed; CESC cis rs17641971 0.684 rs4873100 chr8:50025772 G/A cg00325661 chr8:49890786 NA 0.38 5.35 0.31 1.9e-7 Blood metabolite levels; CESC cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg09640425 chr7:158790006 NA -0.4 -6.44 -0.37 5.44e-10 Facial morphology (factor 20); CESC cis rs72781680 0.566 rs72796106 chr2:23901362 A/C cg20701182 chr2:24300061 SF3B14 0.75 7.56 0.42 6.46e-13 Lymphocyte counts; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22185043 chr18:12947723 SEH1L -0.44 -6.1 -0.35 3.72e-9 Fibrinogen levels; CESC cis rs9815354 0.812 rs73077359 chr3:41850016 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9859260 0.744 rs492288 chr3:195784210 C/T cg12923728 chr3:195709715 SDHAP1 0.54 6.96 0.39 2.68e-11 Mean corpuscular volume; CESC cis rs9906944 0.864 rs9902512 chr17:47094274 C/G cg09029085 chr17:47094198 IGF2BP1 0.26 5.11 0.3 6.12e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs60871478 0.636 rs61441144 chr7:897784 C/T cg13798912 chr7:905769 UNC84A -0.54 -5.43 -0.32 1.29e-7 Cerebrospinal P-tau181p levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27491609 chr17:62779607 LOC146880 0.47 6.6 0.38 2.17e-10 Fibrinogen levels; CESC cis rs28673728 0.868 rs28380108 chr1:38409103 G/C cg04673462 chr1:38461896 NA 0.39 5.92 0.34 9.68e-9 Red cell distribution width; CESC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg06634786 chr22:41940651 POLR3H 0.65 6.57 0.37 2.6200000000000003e-10 Vitiligo; CESC cis rs4474465 1.000 rs11237500 chr11:78163636 G/A cg02023728 chr11:77925099 USP35 0.39 5.04 0.3 8.78e-7 Alzheimer's disease (survival time); CESC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg11941060 chr3:133502564 NA -0.47 -6.33 -0.36 1.04e-9 Iron status biomarkers; CESC cis rs922692 0.715 rs11072803 chr15:79077878 G/A cg04896959 chr15:78267971 NA 0.35 5.1 0.3 6.61e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs10751667 0.666 rs7936830 chr11:959686 A/G cg01483505 chr11:975446 AP2A2 0.37 5.09 0.3 6.77e-7 Alzheimer's disease (late onset); CESC cis rs12220238 1.000 rs10824088 chr10:75921490 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.09 0.35 4.01e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs6714710 0.603 rs2278700 chr2:98427382 T/C cg26665480 chr2:98280029 ACTR1B 0.56 7.96 0.44 5.02e-14 Posterior cortical atrophy and Alzheimer's disease; CESC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg01341218 chr17:43662625 NA -0.87 -10.48 -0.54 9.93e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17482391 chr1:110881020 RBM15 0.52 6.14 0.35 3.06e-9 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs561341 chr17:30316385 T/G cg00745463 chr17:30367425 LRRC37B -0.78 -7.09 -0.4 1.2e-11 Hip circumference adjusted for BMI; CESC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg00166722 chr3:10149974 C3orf24 -0.45 -5.94 -0.34 8.84e-9 Alzheimer's disease; CESC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg00129232 chr17:37814104 STARD3 -0.57 -7.33 -0.41 2.77e-12 Glomerular filtration rate (creatinine); CESC cis rs8114671 0.562 rs6088655 chr20:33527838 A/G cg06115741 chr20:33292138 TP53INP2 0.48 5.78 0.33 2.13e-8 Height; CESC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.45e-21 Prudent dietary pattern; CESC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg16049864 chr8:95962084 TP53INP1 -0.69 -12.32 -0.6 6.82e-28 Type 2 diabetes; CESC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg22508957 chr16:3507546 NAT15 -0.69 -7.52 -0.42 8.76e-13 Tuberculosis; CESC cis rs9303401 0.580 rs34076823 chr17:57114497 C/G cg12560992 chr17:57184187 TRIM37 0.5 5.2 0.3 3.94e-7 Cognitive test performance; CESC cis rs6594713 0.717 rs17331844 chr5:112914426 G/T cg12552261 chr5:112820674 MCC 0.57 5.55 0.32 6.94e-8 Brain cytoarchitecture; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg23965352 chr5:92603043 NA -0.46 -6.25 -0.36 1.59e-9 Gut microbiota (bacterial taxa); CESC cis rs2294693 0.947 rs9349176 chr6:40989525 C/T cg14769373 chr6:40998127 UNC5CL -0.47 -6.59 -0.38 2.41e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg22903657 chr4:1355424 KIAA1530 -0.4 -5.67 -0.33 3.82e-8 Obesity-related traits; CESC cis rs9457247 0.967 rs1187532 chr6:167382020 G/A cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 5.12e-16 Crohn's disease; CESC trans rs3780486 1.000 rs10813951 chr9:33128021 C/T cg04842962 chr6:43655489 MRPS18A -0.91 -13.82 -0.65 4.43e-33 IgG glycosylation; CESC cis rs739401 0.595 rs6578305 chr11:3001120 C/T cg08508325 chr11:3079039 CARS -0.49 -9.26 -0.49 7.24e-18 Longevity; CESC cis rs6754311 0.731 rs12615624 chr2:136721603 A/G cg15123519 chr2:136567270 LCT -0.3 -5.16 -0.3 4.95e-7 Mosquito bite size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14105000 chr17:55193516 AKAP1 -0.54 -6.59 -0.38 2.37e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs2207785 chr6:146332784 T/G cg23711669 chr6:146136114 FBXO30 0.81 11.57 0.58 2.49e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg10578991 chr7:12443926 VWDE -0.45 -5.11 -0.3 6.15e-7 Coronary artery disease; CESC cis rs902774 0.597 rs7299694 chr12:53352572 A/C cg25025879 chr12:53359317 NA -0.48 -6.35 -0.36 9.47e-10 Prostate cancer; CESC trans rs208520 0.661 rs1100950 chr6:66827285 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.85 -0.62 1.09e-29 Exhaled nitric oxide output; CESC cis rs5760092 0.618 rs4461358 chr22:24260106 T/C cg09033563 chr22:24373618 LOC391322 0.48 5.8 0.34 1.89e-8 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs113835537 0.529 rs2279865 chr11:66203025 A/C cg24851651 chr11:66362959 CCS 0.46 5.99 0.35 6.96e-9 Airway imaging phenotypes; CESC cis rs9443645 0.901 rs7767100 chr6:79810533 A/C cg05283184 chr6:79620031 NA -0.43 -6.66 -0.38 1.56e-10 Intelligence (multi-trait analysis); CESC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg03352830 chr11:487213 PTDSS2 0.7 6.71 0.38 1.16e-10 Body mass index; CESC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg24829409 chr8:58192753 C8orf71 -0.67 -7.32 -0.41 3e-12 Developmental language disorder (linguistic errors); CESC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg22823121 chr1:150693482 HORMAD1 0.49 7.19 0.4 6.7e-12 Tonsillectomy; CESC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.89 0.39 4.08e-11 Bipolar disorder; CESC cis rs4566357 0.615 rs2272200 chr2:227912331 G/A cg05526886 chr2:227700861 RHBDD1 -0.46 -6.15 -0.35 2.81e-9 Coronary artery disease; CESC cis rs9527 0.571 rs10786715 chr10:104620735 G/C cg04362960 chr10:104952993 NT5C2 0.47 6.01 0.35 6e-9 Arsenic metabolism; CESC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 6.3 0.36 1.2e-9 LDL cholesterol;Cholesterol, total; CESC cis rs9303401 0.659 rs72828726 chr17:56951217 C/G cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.79 0.62 1.74e-29 Cognitive test performance; CESC cis rs10751667 0.666 rs6597958 chr11:978087 C/T cg06064525 chr11:970664 AP2A2 -0.47 -9.12 -0.49 1.9e-17 Alzheimer's disease (late onset); CESC cis rs36051895 0.632 rs12115301 chr9:5180548 A/G cg02405213 chr9:5042618 JAK2 0.5 6.08 0.35 4.27e-9 Pediatric autoimmune diseases; CESC cis rs365132 0.967 rs11740768 chr5:176339499 G/A cg16309518 chr5:176445507 NA -0.41 -6.03 -0.35 5.49e-9 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs17253792 0.545 rs35294669 chr14:56017438 T/A cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs3752962 0.569 rs12451788 chr17:1941048 C/T cg24156229 chr17:1948635 NA 0.62 9.57 0.51 7.82e-19 Itch intensity from mosquito bite; CESC cis rs11674184 0.714 rs9789525 chr2:11724580 G/T cg07314298 chr2:11723111 GREB1 -0.66 -10.06 -0.53 2.28e-20 Endometriosis; CESC cis rs4727027 0.866 rs35599790 chr7:148806012 C/T cg23583168 chr7:148888333 NA -0.79 -12.1 -0.6 4.02e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg06634786 chr22:41940651 POLR3H -0.69 -6.9 -0.39 3.9e-11 Vitiligo; CESC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg03351412 chr1:154909251 PMVK 0.69 9.39 0.5 2.91e-18 Prostate cancer; CESC cis rs7481584 0.926 rs12806061 chr11:3008404 G/A cg25174290 chr11:3078921 CARS -0.49 -6.08 -0.35 4.07e-9 Calcium levels; CESC cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg25405998 chr7:65216604 CCT6P1 0.51 5.52 0.32 8.13e-8 Aortic root size; CESC cis rs2230307 0.536 rs506044 chr1:100611931 A/G cg24955406 chr1:100503596 HIAT1 -0.49 -5.18 -0.3 4.29e-7 Carotid intima media thickness; CESC cis rs1178968 0.818 rs2108235 chr7:72783383 A/G cg25889504 chr7:72793014 NA 0.44 5.07 0.3 7.38e-7 Triglyceride levels; CESC cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -5.64 -0.33 4.43e-8 Monocyte percentage of white cells; CESC cis rs3820068 0.580 rs7556473 chr1:15996858 C/T cg18133145 chr1:16060689 PLEKHM2 0.47 5.9 0.34 1.12e-8 Systolic blood pressure; CESC cis rs13256369 0.802 rs12541520 chr8:8564146 G/T cg17143192 chr8:8559678 CLDN23 0.76 9.02 0.48 3.85e-17 Obesity-related traits; CESC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg11742103 chr11:62369870 EML3;MTA2 0.65 9.46 0.5 1.69e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2115536 1.000 rs11072871 chr15:80197931 T/C cg00225070 chr15:80189496 MTHFS 0.54 7.26 0.41 4.41e-12 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs9911578 1.000 rs2333332 chr17:56631054 A/G cg05425664 chr17:57184151 TRIM37 0.5 6.93 0.39 3.29e-11 Intelligence (multi-trait analysis); CESC cis rs1005277 0.505 rs13503 chr10:38239843 C/A cg25427524 chr10:38739819 LOC399744 0.71 10.68 0.55 2.25e-22 Extrinsic epigenetic age acceleration; CESC cis rs6446731 0.734 rs9996868 chr4:3275484 C/T cg08886695 chr4:3369023 RGS12 -0.36 -5.16 -0.3 4.83e-7 Mean platelet volume; CESC cis rs8050907 0.744 rs77430528 chr16:4523389 T/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.89 5.66 0.33 3.84e-8 Obesity-related traits; CESC cis rs11148252 0.532 rs9536190 chr13:53181044 T/C cg00495681 chr13:53174319 NA 0.67 9.12 0.49 1.99e-17 Lewy body disease; CESC cis rs8062405 1.000 rs3088215 chr16:28853996 A/C cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6973256 0.543 rs13243553 chr7:133506955 A/G cg10665199 chr7:133106180 EXOC4 -0.44 -5.95 -0.34 8.63e-9 Intelligence (multi-trait analysis); CESC cis rs4664304 1.000 rs6735923 chr2:160769588 A/G cg03641300 chr2:160917029 PLA2R1 -0.48 -6.78 -0.38 7.98e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs3126085 0.544 rs3126074 chr1:152279841 G/C cg03465714 chr1:152285911 FLG 0.43 5.2 0.3 3.91e-7 Atopic dermatitis; CESC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg19257562 chr1:2043853 PRKCZ 0.34 5.66 0.33 3.9e-8 Height; CESC cis rs78132593 0.796 rs72992015 chr1:150842696 C/T cg04414720 chr1:150670196 GOLPH3L -0.53 -5.28 -0.31 2.72e-7 High light scatter reticulocyte count; CESC cis rs858239 0.600 rs59073109 chr7:23133226 C/A cg23682824 chr7:23144976 KLHL7 0.54 7.34 0.41 2.63e-12 Cerebrospinal fluid biomarker levels; CESC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg24531977 chr5:56204891 C5orf35 -0.67 -9.25 -0.49 7.78e-18 Initial pursuit acceleration; CESC cis rs4822044 0.560 rs7284839 chr22:42010902 C/T cg17376030 chr22:41985996 PMM1 -0.8 -8.91 -0.48 8.57e-17 Cannabis dependence symptom count; CESC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg24829409 chr8:58192753 C8orf71 -0.77 -10.02 -0.52 2.95e-20 Developmental language disorder (linguistic errors); CESC cis rs367943 0.712 rs26968 chr5:112742429 A/G cg12552261 chr5:112820674 MCC 0.4 5.35 0.31 1.89e-7 Type 2 diabetes; CESC cis rs11122272 0.735 rs2066140 chr1:231504311 C/G cg06096015 chr1:231504339 EGLN1 0.42 6.26 0.36 1.56e-9 Hemoglobin concentration; CESC cis rs9287719 0.967 rs2110778 chr2:10748970 A/T cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs6691722 0.583 rs35671964 chr1:24695749 C/G cg02336364 chr1:24764700 NIPAL3 0.29 5.79 0.34 1.95e-8 Response to interferon beta in multiple sclerosis; CESC cis rs6964587 0.839 rs6952459 chr7:91435820 T/A cg17063962 chr7:91808500 NA 0.49 6.21 0.36 1.99e-9 Breast cancer; CESC cis rs35160687 0.623 rs7569654 chr2:86478022 C/T cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.18 -0.3 4.5e-7 Night sleep phenotypes; CESC cis rs116095464 0.558 rs9687898 chr5:253952 A/G cg22496380 chr5:211416 CCDC127 -0.73 -8.39 -0.46 2.99e-15 Breast cancer; CESC cis rs17376456 0.877 rs9314099 chr5:93447375 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.44 0.32 1.23e-7 Diabetic retinopathy; CESC cis rs10463316 0.894 rs7707964 chr5:150765475 C/T cg03212797 chr5:150827313 SLC36A1 -0.49 -6.4 -0.37 6.94e-10 Metabolite levels (Pyroglutamine); CESC cis rs2734839 0.537 rs10891549 chr11:113278447 T/C cg14159747 chr11:113255604 NA 0.36 6.48 0.37 4.52e-10 Information processing speed; CESC cis rs748404 0.697 rs579651 chr15:43558376 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.84 0.43 1.08e-13 Lung cancer; CESC cis rs8141529 0.509 rs5762863 chr22:29253335 A/C cg15103426 chr22:29168792 CCDC117 0.63 8.51 0.46 1.29e-15 Lymphocyte counts; CESC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg17340268 chr14:105411764 AHNAK2 -0.51 -6.84 -0.39 5.32e-11 Rheumatoid arthritis; CESC cis rs5769765 0.955 rs5769761 chr22:50263641 G/T cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs854765 0.583 rs12452219 chr17:17829423 C/T cg04398451 chr17:18023971 MYO15A -0.65 -9.11 -0.49 2.07e-17 Total body bone mineral density; CESC cis rs734999 0.524 rs4648448 chr1:2695687 C/T cg20673091 chr1:2541236 MMEL1 0.48 7.76 0.43 1.89e-13 Ulcerative colitis; CESC cis rs7412746 0.611 rs7532045 chr1:150821847 G/A cg22823121 chr1:150693482 HORMAD1 0.39 5.55 0.32 6.99e-8 Melanoma; CESC cis rs523522 1.000 rs523522 chr12:121020250 A/T cg27279351 chr12:120934652 DYNLL1 0.72 9.32 0.5 4.74e-18 High light scatter reticulocyte count; CESC trans rs875971 0.660 rs801217 chr7:66010577 C/T cg26939375 chr7:64535504 NA -0.63 -8.63 -0.47 5.82e-16 Aortic root size; CESC cis rs9612 0.664 rs164069 chr19:44260199 T/C cg08581076 chr19:44259116 C19orf61 0.45 5.54 0.32 7.16e-8 Exhaled nitric oxide output; CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.42 8.27 0.45 6.75e-15 Electroencephalogram traits; CESC cis rs4660261 0.526 rs2906458 chr1:44336389 A/G cg13606994 chr1:44402422 ARTN 0.38 5.75 0.33 2.41e-8 Intelligence (multi-trait analysis); CESC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.27 -0.31 2.82e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg22535103 chr8:58192502 C8orf71 -0.93 -11.66 -0.58 1.19e-25 Developmental language disorder (linguistic errors); CESC cis rs8028182 0.636 rs62027209 chr15:75871626 A/G cg20655648 chr15:75932815 IMP3 0.55 7.01 0.4 1.95e-11 Sudden cardiac arrest; CESC cis rs365132 1.000 rs2292255 chr5:176334195 C/T cg16309518 chr5:176445507 NA -0.41 -6.02 -0.35 5.77e-9 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7429990 0.930 rs11130152 chr3:48056409 T/C cg11946769 chr3:48343235 NME6 -0.43 -5.17 -0.3 4.63e-7 Educational attainment (years of education); CESC cis rs6582630 0.555 rs10880607 chr12:38508184 A/G cg26384229 chr12:38710491 ALG10B 0.72 10.68 0.55 2.17e-22 Drug-induced liver injury (flucloxacillin); CESC trans rs2099077 0.737 rs12515712 chr5:102781210 G/T cg07434438 chr16:72961899 ZFHX3 0.44 6.09 0.35 3.87e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2795502 0.554 rs1620395 chr10:43341185 G/A cg20628663 chr10:43360327 NA -0.42 -5.76 -0.33 2.36e-8 Blood protein levels; CESC cis rs2933343 1.000 rs2630252 chr3:128624772 T/C cg25356066 chr3:128598488 ACAD9 0.59 7.16 0.4 7.76e-12 IgG glycosylation; CESC cis rs9796 0.624 rs9920619 chr15:41318845 A/G cg18705301 chr15:41695430 NDUFAF1 -0.44 -6.17 -0.35 2.48e-9 Menopause (age at onset); CESC cis rs75477785 1.000 rs10779514 chr1:209987624 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg25036284 chr2:26402008 FAM59B 0.84 9.47 0.5 1.61e-18 Gut microbiome composition (summer); CESC cis rs4704187 0.687 rs10051572 chr5:74502797 G/A cg03227963 chr5:74354835 NA 0.28 5.18 0.3 4.33e-7 Response to amphetamines; CESC cis rs9457247 0.967 rs447042 chr6:167405435 C/T cg07741184 chr6:167504864 NA 0.29 5.31 0.31 2.32e-7 Crohn's disease; CESC cis rs9733 0.744 rs2089081 chr1:150800117 T/C cg18016565 chr1:150552671 MCL1 -0.34 -5.62 -0.33 4.84e-8 Tonsillectomy; CESC cis rs9916302 0.904 rs11078897 chr17:37415870 C/T cg20243544 chr17:37824526 PNMT 0.47 5.83 0.34 1.64e-8 Glomerular filtration rate (creatinine); CESC cis rs5769765 0.954 rs5770739 chr22:50268014 C/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs2073300 0.609 rs6137907 chr20:23344511 C/T cg12062639 chr20:23401060 NAPB 0.98 7.59 0.42 5.37e-13 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg22875332 chr1:76189707 ACADM -0.64 -7.57 -0.42 6.05e-13 Blood metabolite levels;Acylcarnitine levels; CESC trans rs1423617 1.000 rs1423617 chr5:50801564 G/A cg04420932 chr11:67195621 RPS6KB2 0.55 6.01 0.35 6.1e-9 Childhood ear infection; CESC cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.09e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7933455 0.502 rs1385850 chr11:12234595 C/T cg10383724 chr11:12228521 MICAL2 0.57 6.79 0.39 7.3e-11 Cold sores; CESC cis rs6964587 0.900 rs4279 chr7:91764128 C/A cg17063962 chr7:91808500 NA 0.58 8.09 0.45 2.09e-14 Breast cancer; CESC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg06108461 chr20:60628389 TAF4 -0.92 -14.55 -0.67 1.22e-35 Body mass index; CESC cis rs1559088 0.947 rs12461297 chr19:33559245 A/G cg17764715 chr19:33622953 WDR88 0.47 5.82 0.34 1.67e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16282910 chr9:112296723 NA 0.48 6.68 0.38 1.41e-10 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19983870 chr19:56671579 ZNF444 0.47 6.14 0.35 3e-9 Fibrinogen levels; CESC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.4e-8 Tonsillectomy; CESC cis rs12497850 1.000 rs10865952 chr3:48744484 A/G cg06212747 chr3:49208901 KLHDC8B 0.62 8.15 0.45 1.41e-14 Parkinson's disease; CESC cis rs9649465 1.000 rs9641715 chr7:123348623 A/G cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.46e-7 Migraine; CESC cis rs2742234 0.541 rs11238490 chr10:43747598 G/A cg03680517 chr10:43632967 CSGALNACT2 -0.41 -5.11 -0.3 6.15e-7 Hirschsprung disease; CESC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7116495 1.000 rs17161991 chr11:71839960 T/C cg26138937 chr11:71823887 C11orf51 0.78 6.22 0.36 1.98e-9 Severe influenza A (H1N1) infection; CESC cis rs60871478 0.947 rs62432239 chr7:794576 C/T cg05535760 chr7:792225 HEATR2 0.85 10.54 0.54 6.53e-22 Cerebrospinal P-tau181p levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01383268 chr17:71088868 SLC39A11 -0.43 -6.16 -0.35 2.63e-9 Gambling; CESC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg12311346 chr5:56204834 C5orf35 -0.64 -8.82 -0.48 1.55e-16 Initial pursuit acceleration; CESC trans rs877282 0.891 rs12357999 chr10:796468 A/C cg22713356 chr15:30763199 NA 1.32 13.47 0.64 7.47e-32 Uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01742680 chr3:152879841 RAP2B 0.59 7.25 0.41 4.65e-12 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs316326 chr7:65609453 T/C cg13147721 chr7:65941812 NA -0.97 -9.14 -0.49 1.7e-17 Diabetic kidney disease; CESC cis rs2625529 0.824 rs12906711 chr15:72215065 A/G cg16672083 chr15:72433130 SENP8 -0.39 -5.07 -0.3 7.49e-7 Red blood cell count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26347379 chr8:99956585 OSR2 -0.47 -6.38 -0.36 7.79e-10 Fibrinogen levels; CESC cis rs7116495 0.609 rs2155145 chr11:71719619 G/T cg07596299 chr11:71824057 C11orf51 -0.82 -5.33 -0.31 2.13e-7 Severe influenza A (H1N1) infection; CESC cis rs9858542 0.953 rs6446272 chr3:49463287 G/A cg03060546 chr3:49711283 APEH -0.55 -6.21 -0.36 2.08e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7828089 0.582 rs3817445 chr8:22266054 G/T cg13512537 chr8:22265999 SLC39A14 -0.41 -5.76 -0.33 2.3e-8 Verbal declarative memory; CESC cis rs9457247 0.765 rs1060404 chr6:167429467 A/G cg23791538 chr6:167370224 RNASET2 -0.54 -7.46 -0.42 1.26e-12 Crohn's disease; CESC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg25517755 chr10:38738941 LOC399744 -0.49 -6.35 -0.36 9.09e-10 Extrinsic epigenetic age acceleration; CESC cis rs7914558 0.966 rs10786725 chr10:104682357 T/C cg08650961 chr10:104748594 CNNM2 0.32 5.12 0.3 5.86e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg12963246 chr6:28129442 ZNF389 -0.59 -7.87 -0.44 9.36e-14 Depression; CESC cis rs4319547 0.626 rs10744210 chr12:122931793 A/G cg23029597 chr12:123009494 RSRC2 -0.45 -5.08 -0.3 7.04e-7 Body mass index; CESC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg02569458 chr12:86230093 RASSF9 0.48 7.18 0.4 6.9e-12 Major depressive disorder; CESC cis rs1904096 0.506 rs10034781 chr4:95169682 A/C cg11021082 chr4:95130006 SMARCAD1 0.62 9.54 0.51 9.85e-19 Type 2 diabetes; CESC cis rs10504073 0.647 rs10435612 chr8:49993696 A/T cg00325661 chr8:49890786 NA 0.55 8.17 0.45 1.29e-14 Blood metabolite ratios; CESC cis rs7546094 0.875 rs1110043 chr1:113236421 G/A cg22162597 chr1:113214053 CAPZA1 -0.35 -5.15 -0.3 5.05e-7 Platelet distribution width; CESC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg26338869 chr17:61819248 STRADA -0.62 -7.86 -0.43 9.7e-14 Prudent dietary pattern; CESC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.05 0.4 1.57e-11 Height; CESC cis rs67460515 0.892 rs34771618 chr3:161059795 A/C cg03342759 chr3:160939853 NMD3 -0.54 -7.83 -0.43 1.17e-13 Parkinson's disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03758392 chr3:184870408 C3orf70 0.48 6.69 0.38 1.28e-10 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs28451001 chr4:98924544 T/A cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs506597 0.920 rs221803 chr7:100291200 C/T cg10426581 chr7:100472382 SRRT -0.72 -5.39 -0.31 1.53e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs116095464 0.614 rs28736753 chr5:274081 G/A cg20965017 chr5:231967 SDHA -0.49 -5.39 -0.31 1.59e-7 Breast cancer; CESC cis rs4253772 0.515 rs77797820 chr22:46771270 C/T cg00784671 chr22:46762841 CELSR1 -0.71 -6.0 -0.35 6.48e-9 LDL cholesterol;Cholesterol, total; CESC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg23048001 chr7:2026167 MAD1L1 0.45 5.8 0.34 1.85e-8 Schizophrenia; CESC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg05313129 chr8:58192883 C8orf71 -0.56 -5.84 -0.34 1.56e-8 Developmental language disorder (linguistic errors); CESC cis rs9488822 0.676 rs12190737 chr6:116328128 C/A cg15226275 chr6:116381976 FRK 0.24 6.16 0.35 2.73e-9 Cholesterol, total;LDL cholesterol; CESC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.01 0.52 3.17e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19731367 chr10:95256484 CEP55 0.55 6.6 0.38 2.26e-10 Gut microbiome composition (summer); CESC cis rs1401999 1.000 rs1401999 chr3:183678342 C/G cg01324343 chr3:183735012 ABCC5 0.63 13.53 0.64 4.5e-32 Anterior chamber depth; CESC cis rs7772486 0.806 rs4075696 chr6:146250947 T/C cg23711669 chr6:146136114 FBXO30 -0.77 -10.89 -0.56 4.58e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.1 0.6 3.86e-27 Alzheimer's disease; CESC cis rs11098499 0.619 rs28502463 chr4:120257023 T/C cg09307838 chr4:120376055 NA 0.81 10.94 0.56 3.14e-23 Corneal astigmatism; CESC cis rs11098499 0.954 rs2389802 chr4:120325732 C/A cg24375607 chr4:120327624 NA 0.46 5.79 0.34 2e-8 Corneal astigmatism; CESC cis rs2562152 0.706 rs216596 chr16:105320 A/G cg02949481 chr16:131562 MPG 0.52 5.73 0.33 2.69e-8 Glioblastoma; CESC cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs561341 1.000 rs2470267 chr17:30274132 G/A cg00745463 chr17:30367425 LRRC37B -0.68 -6.78 -0.38 7.66e-11 Hip circumference adjusted for BMI; CESC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 11.62 0.58 1.68e-25 Alzheimer's disease; CESC cis rs12477438 0.520 rs13030961 chr2:99799520 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.86 0.7 2.83e-40 Chronic sinus infection; CESC cis rs28374715 0.617 rs16971733 chr15:41562030 C/A cg18705301 chr15:41695430 NDUFAF1 -0.53 -7.59 -0.42 5.57e-13 Ulcerative colitis; CESC cis rs2070488 0.745 rs7649153 chr3:38467753 T/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.68 8.89 0.48 9.74e-17 Electrocardiographic conduction measures; CESC cis rs9815354 1.000 rs114960066 chr3:41882323 A/G cg03022575 chr3:42003672 ULK4 0.45 5.29 0.31 2.59e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs2070677 0.935 rs11101885 chr10:135417088 T/C cg20169779 chr10:135381914 SYCE1 -0.72 -9.59 -0.51 6.83e-19 Gout; CESC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg24531977 chr5:56204891 C5orf35 -0.75 -7.53 -0.42 7.95e-13 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06169648 chr16:85646832 KIAA0182 0.49 6.1 0.35 3.7e-9 Gut microbiota (bacterial taxa); CESC cis rs17376456 0.825 rs28645862 chr5:93233128 G/C cg25358565 chr5:93447407 FAM172A 1.09 10.53 0.54 6.82e-22 Diabetic retinopathy; CESC cis rs7216064 1.000 rs62085992 chr17:65923083 T/A cg12091567 chr17:66097778 LOC651250 -0.8 -8.08 -0.44 2.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs929596 0.785 rs11695484 chr2:234654449 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.7 -8.81 -0.48 1.64e-16 Total bilirubin levels in HIV-1 infection; CESC cis rs6582630 0.537 rs1851124 chr12:38516404 G/A cg13010199 chr12:38710504 ALG10B 0.49 6.43 0.37 6.06e-10 Drug-induced liver injury (flucloxacillin); CESC trans rs11098499 0.863 rs11723090 chr4:120490592 T/C cg25214090 chr10:38739885 LOC399744 0.65 8.73 0.47 2.86e-16 Corneal astigmatism; CESC cis rs9287719 0.934 rs10181806 chr2:10741141 A/G cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs2247341 1.000 rs3958122 chr4:1693931 C/T cg07465881 chr4:1713556 SLBP -0.53 -6.85 -0.39 5.23e-11 Hip circumference adjusted for BMI;Height; CESC cis rs1008375 0.843 rs59112113 chr4:17685336 A/T cg16339924 chr4:17578868 LAP3 0.5 6.47 0.37 4.69e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs116095464 0.614 rs78905930 chr5:246560 G/A cg22496380 chr5:211416 CCDC127 -0.79 -9.2 -0.49 1.07e-17 Breast cancer; CESC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg02038168 chr22:39784481 NA 0.57 7.05 0.4 1.52e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg08888203 chr3:10149979 C3orf24 0.48 6.06 0.35 4.71e-9 Alzheimer's disease; CESC cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.87 -13.01 -0.62 3.07e-30 Systemic lupus erythematosus; CESC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg00074818 chr8:8560427 CLDN23 0.36 5.35 0.31 1.89e-7 Obesity-related traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02576092 chr1:27668556 SYTL1 -0.42 -6.28 -0.36 1.39e-9 Gambling; CESC cis rs6570726 0.935 rs9390329 chr6:145828026 T/C cg23711669 chr6:146136114 FBXO30 0.78 11.62 0.58 1.64e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs6088580 0.634 rs62212172 chr20:32987705 G/A cg24642439 chr20:33292090 TP53INP2 -0.52 -6.9 -0.39 3.82e-11 Glomerular filtration rate (creatinine); CESC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg24531977 chr5:56204891 C5orf35 -0.49 -6.0 -0.35 6.46e-9 Coronary artery disease; CESC cis rs10504229 0.531 rs55923836 chr8:57999127 A/G cg24829409 chr8:58192753 C8orf71 -0.42 -5.5 -0.32 8.75e-8 Developmental language disorder (linguistic errors); CESC cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg00255919 chr5:131827918 IRF1 0.51 8.59 0.47 7.76e-16 Asthma (sex interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09656405 chr15:69745057 RPLP1 -0.44 -6.25 -0.36 1.6e-9 Gambling; CESC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg08027265 chr7:2291960 NA -0.41 -6.34 -0.36 9.6e-10 Schizophrenia; CESC cis rs7208859 0.673 rs73277967 chr17:29184166 T/A cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2455799 0.613 rs2470547 chr3:15737610 T/C cg16303742 chr3:15540471 COLQ -0.36 -5.63 -0.33 4.5e-8 Mean platelet volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22879676 chr17:81009871 B3GNTL1 -0.46 -6.09 -0.35 3.86e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs17685 0.587 rs1623759 chr7:75724679 A/T cg19862616 chr7:65841803 NCRNA00174 0.87 12.7 0.62 3.58e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs60154123 0.772 rs845452 chr1:210417861 C/T cg22029157 chr1:209979665 IRF6 0.52 5.89 0.34 1.15e-8 Coronary artery disease; CESC cis rs796364 0.806 rs11694236 chr2:200916230 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg13866156 chr1:1669148 SLC35E2 -0.5 -6.62 -0.38 1.97e-10 Body mass index; CESC cis rs7772486 0.875 rs9403763 chr6:146357655 A/G cg23711669 chr6:146136114 FBXO30 0.85 12.46 0.61 2.27e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs977987 0.966 rs8055490 chr16:75497135 C/T cg03315344 chr16:75512273 CHST6 0.54 7.91 0.44 6.89e-14 Dupuytren's disease; CESC cis rs8020095 0.571 rs8012660 chr14:67300671 T/A cg19548862 chr14:67692701 FAM71D -0.48 -5.87 -0.34 1.27e-8 Depression (quantitative trait); CESC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg22535103 chr8:58192502 C8orf71 -1.04 -12.83 -0.62 1.26e-29 Developmental language disorder (linguistic errors); CESC cis rs9291683 0.645 rs11557743 chr4:10118377 C/G cg00071950 chr4:10020882 SLC2A9 -0.52 -8.1 -0.45 1.96e-14 Bone mineral density; CESC cis rs16866061 0.517 rs7580488 chr2:225473263 C/T cg12698349 chr2:225449008 CUL3 0.47 6.16 0.35 2.69e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg17143192 chr8:8559678 CLDN23 0.78 8.81 0.48 1.63e-16 Obesity-related traits; CESC cis rs3785574 0.621 rs1051684 chr17:62006497 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.45 -5.52 -0.32 7.99e-8 Height; CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.34 -0.36 9.9e-10 Depression; CESC cis rs7078219 0.505 rs7085798 chr10:101288347 C/A cg09788492 chr10:101292477 NKX2-3 0.32 6.12 0.35 3.29e-9 Dental caries; CESC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.61e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4808199 0.739 rs2240117 chr19:19418916 C/T cg03709012 chr19:19516395 GATAD2A 0.97 8.41 0.46 2.57e-15 Nonalcoholic fatty liver disease; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23198998 chr6:150244323 RAET1G -0.5 -6.87 -0.39 4.65e-11 Height; CESC cis rs929354 0.772 rs1182364 chr7:157017912 T/C cg05182265 chr7:156933206 UBE3C 0.52 7.57 0.42 6.2800000000000005e-13 Body mass index; CESC trans rs4942242 0.512 rs9533552 chr13:44187194 C/T cg19169023 chr15:41853346 TYRO3 -0.68 -8.5 -0.46 1.36e-15 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9362426 1.000 rs1203156 chr6:88079694 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.49 6.17 0.35 2.61e-9 Depressive episodes in bipolar disorder; CESC cis rs12142240 0.698 rs41294458 chr1:46810304 T/C cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg05368731 chr17:41323189 NBR1 0.6 8.36 0.46 3.63e-15 Menopause (age at onset); CESC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg02725872 chr8:58115012 NA -0.42 -5.85 -0.34 1.48e-8 Developmental language disorder (linguistic errors); CESC cis rs9837602 1.000 rs9832186 chr3:99728503 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.51 0.42 9.05e-13 Breast cancer; CESC cis rs425277 1.000 rs262670 chr1:2082458 C/T cg24578937 chr1:2090814 PRKCZ 0.55 9.54 0.51 9.57e-19 Height; CESC cis rs933688 0.938 rs1477348 chr5:90707823 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.82 0.59 3.43e-26 Smoking behavior; CESC cis rs7605827 0.930 rs10929372 chr2:15662434 A/G cg19274914 chr2:15703543 NA 0.36 6.32 0.36 1.12e-9 Educational attainment (years of education); CESC trans rs9929218 1.000 rs13334326 chr16:68809207 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -8.04 -0.44 2.94e-14 Colorectal cancer; CESC cis rs67311347 1.000 rs951560 chr3:40463471 A/G cg24209194 chr3:40518798 ZNF619 0.45 5.84 0.34 1.54e-8 Renal cell carcinoma; CESC cis rs2242116 0.592 rs2290545 chr3:46967040 C/T cg02527881 chr3:46936655 PTH1R -0.41 -5.09 -0.3 6.66e-7 Birth weight; CESC cis rs3820928 0.874 rs7423610 chr2:227836262 A/G cg11843606 chr2:227700838 RHBDD1 -0.45 -5.77 -0.33 2.22e-8 Pulmonary function; CESC cis rs2996428 0.709 rs6424052 chr1:3713746 A/G cg13057898 chr1:3703894 LRRC47 0.47 6.33 0.36 1.04e-9 Red cell distribution width; CESC cis rs2230307 0.536 rs834278 chr1:100510882 T/C cg24955406 chr1:100503596 HIAT1 0.56 5.47 0.32 1.06e-7 Carotid intima media thickness; CESC cis rs708547 0.578 rs781665 chr4:57831461 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.59 7.57 0.42 6.36e-13 Response to bleomycin (chromatid breaks); CESC cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.86 -0.39 4.91e-11 Hemoglobin concentration; CESC cis rs3126085 0.935 rs3120659 chr1:152293202 A/G cg03465714 chr1:152285911 FLG 0.43 5.2 0.3 3.91e-7 Atopic dermatitis; CESC trans rs9329221 0.935 rs3750310 chr8:10283426 G/A cg17143192 chr8:8559678 CLDN23 -0.56 -6.25 -0.36 1.6e-9 Neuroticism; CESC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg04315214 chr1:2043799 PRKCZ 0.43 6.99 0.39 2.24e-11 Height; CESC trans rs1814175 0.533 rs4528310 chr11:49983106 C/A cg15704280 chr7:45808275 SEPT13 -1.01 -19.0 -0.76 2.27e-51 Height; CESC cis rs8077577 0.945 rs62073604 chr17:18065888 T/C cg16794390 chr17:18148240 FLII 0.41 5.65 0.33 4.04e-8 Obesity-related traits; CESC cis rs2832191 0.633 rs2832166 chr21:30462395 G/C cg24692254 chr21:30365293 RNF160 0.95 15.46 0.69 7.36e-39 Dental caries; CESC cis rs863345 0.526 rs857718 chr1:158595142 T/A cg12129480 chr1:158549410 OR10X1 -0.29 -5.53 -0.32 7.5e-8 Pneumococcal bacteremia; CESC cis rs9308731 0.591 rs7572367 chr2:111942971 C/T cg04202892 chr2:111875749 ACOXL 0.37 5.17 0.3 4.61e-7 Chronic lymphocytic leukemia; CESC cis rs959260 0.623 rs2164244 chr17:73325244 C/T cg12999837 chr17:73267436 MIF4GD -0.41 -5.07 -0.3 7.61e-7 Systemic lupus erythematosus; CESC cis rs78456975 1.000 rs13422995 chr2:1553554 C/A cg01028140 chr2:1542097 TPO -0.51 -5.3 -0.31 2.48e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9902453 0.933 rs8074028 chr17:28461687 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.5 0.42 9.48e-13 Coffee consumption (cups per day); CESC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg03538708 chr1:25844672 NA -0.39 -5.86 -0.34 1.35e-8 Erythrocyte sedimentation rate; CESC cis rs13191362 0.507 rs13211655 chr6:163177542 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.51 5.71 0.33 3.05e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg09365446 chr1:150670422 GOLPH3L 0.38 5.08 0.3 7e-7 Melanoma; CESC cis rs2797160 0.515 rs4897149 chr6:125980018 G/T cg05901451 chr6:126070800 HEY2 0.36 5.08 0.3 7.05e-7 Endometrial cancer; CESC cis rs55823223 0.680 rs57287238 chr17:73850940 T/C cg08125733 chr17:73851984 WBP2 0.91 11.82 0.59 3.7e-26 Psoriasis; CESC trans rs2727020 0.658 rs1851992 chr11:49438110 C/T cg15704280 chr7:45808275 SEPT13 -0.9 -15.53 -0.69 3.95e-39 Coronary artery disease; CESC cis rs26868 0.740 rs26869 chr16:2248786 T/C cg07587117 chr16:2239488 CASKIN1 0.33 5.2 0.3 4.08e-7 Height; CESC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg05863683 chr7:1912471 MAD1L1 -0.44 -6.73 -0.38 1.04e-10 Bipolar disorder and schizophrenia; CESC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg26119090 chr2:26468346 HADHA;HADHB 1.07 12.41 0.61 3.37e-28 Gut microbiome composition (summer); CESC cis rs6582630 0.502 rs11520234 chr12:38255005 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.26 0.53 5.3e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs7918232 0.627 rs10829165 chr10:27319465 A/G cg14442939 chr10:27389572 ANKRD26 0.45 5.08 0.3 7.07e-7 Breast cancer; CESC cis rs4835473 0.897 rs28825455 chr4:144628746 T/C cg25736465 chr4:144833511 NA 0.4 6.1 0.35 3.71e-9 Immature fraction of reticulocytes; CESC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.49 -0.37 4.23e-10 Depression; CESC cis rs6502050 0.835 rs9898697 chr17:80100498 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.15 -0.3 5.06e-7 Life satisfaction; CESC trans rs17307778 1.000 rs2404050 chr11:25357269 G/A cg22888484 chr20:37075185 SNHG11 -0.63 -6.08 -0.35 4.23e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9913156 0.793 rs72835643 chr17:4573612 G/A cg00122941 chr17:4613640 ARRB2 0.88 10.3 0.53 3.7e-21 Lymphocyte counts; CESC cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg10523679 chr1:76189770 ACADM 0.76 9.99 0.52 3.63e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs151234 0.800 rs231974 chr16:28540322 A/T cg01378222 chr16:28622494 SULT1A1 -0.5 -6.1 -0.35 3.8e-9 Platelet distribution width; CESC cis rs74181299 0.855 rs2723066 chr2:65279321 T/G cg05010058 chr2:65284262 CEP68 0.33 5.66 0.33 3.89e-8 Pulse pressure; CESC cis rs7259376 0.694 rs75653200 chr19:22579503 G/T cg02657401 chr19:22469223 NA 0.26 5.14 0.3 5.27e-7 Menopause (age at onset); CESC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg05872129 chr22:39784769 NA 0.82 10.77 0.55 1.17e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs4843747 0.671 rs4075599 chr16:88107423 C/G cg06374794 chr16:88002281 BANP 0.41 5.47 0.32 1.02e-7 Menopause (age at onset); CESC cis rs9814567 0.929 rs1863912 chr3:134205227 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.22 -0.36 1.92e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.68 0.38 1.44e-10 Bipolar disorder; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg11897279 chr19:13044638 FARSA -0.41 -6.0 -0.35 6.45e-9 Vertical cup-disc ratio; CESC cis rs8067545 0.512 rs34726000 chr17:19887821 G/T cg12073167 chr17:19770448 ULK2 -0.47 -5.67 -0.33 3.79e-8 Schizophrenia; CESC cis rs11166927 0.716 rs4736094 chr8:140802186 G/A cg16909799 chr8:140841666 TRAPPC9 0.45 6.19 0.36 2.23e-9 Pediatric non-alcoholic fatty liver disease activity score; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05380008 chr22:42466865 NAGA 0.54 6.0 0.35 6.32e-9 Gut microbiome composition (summer); CESC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg00277769 chr7:97922759 BAIAP2L1 0.33 5.47 0.32 1.06e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs11125080 0.735 rs7609080 chr2:46733783 A/G cg02822958 chr2:46747628 ATP6V1E2 0.54 5.15 0.3 5.06e-7 Anti-saccade response;Anti-saccade error rate in psychotic disorders; CESC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg24250549 chr1:154909240 PMVK 0.72 10.53 0.54 6.84e-22 Prostate cancer; CESC cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg03467027 chr4:99064603 C4orf37 0.45 5.72 0.33 2.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7017914 0.967 rs17689955 chr8:71848864 C/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.43 -5.42 -0.32 1.33e-7 Bone mineral density; CESC cis rs9902453 0.874 rs7220004 chr17:28369548 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.69 -0.47 3.79e-16 Coffee consumption (cups per day); CESC trans rs801193 0.967 rs34356500 chr7:66236607 G/T cg14393609 chr7:65229607 NA 0.47 6.14 0.35 2.96e-9 Aortic root size; CESC cis rs847577 0.677 rs951988 chr7:97762474 C/G cg24562669 chr7:97807699 LMTK2 -0.57 -8.49 -0.46 1.46e-15 Breast cancer; CESC cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg00745463 chr17:30367425 LRRC37B -0.87 -7.84 -0.43 1.08e-13 Hip circumference adjusted for BMI; CESC cis rs503341 0.756 rs612010 chr11:63591005 G/A cg04362095 chr11:63592001 C11orf84 -0.58 -8.42 -0.46 2.4e-15 Pulse pressure; CESC cis rs7224314 1.000 rs62084080 chr17:65387014 C/T cg01507342 chr17:65387096 PITPNC1 -0.47 -5.66 -0.33 3.86e-8 Diisocyanate-induced asthma; CESC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg11644478 chr21:40555479 PSMG1 1.06 17.5 0.73 4.14e-46 Cognitive function; CESC cis rs7914558 0.966 rs2297786 chr10:104679978 C/T cg15744005 chr10:104629667 AS3MT -0.35 -5.49 -0.32 9.37e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6540559 0.546 rs74991018 chr1:210033790 T/G cg25204440 chr1:209979598 IRF6 0.67 6.11 0.35 3.54e-9 Cleft lip with or without cleft palate; CESC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs7927771 0.524 rs7110300 chr11:47848442 T/G cg20307385 chr11:47447363 PSMC3 0.62 8.62 0.47 6.37e-16 Subjective well-being; CESC cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg03433033 chr1:76189801 ACADM 0.65 7.82 0.43 1.24e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs34779708 0.931 rs12776390 chr10:35391535 T/G cg04310649 chr10:35416472 CREM -0.54 -6.56 -0.37 2.77e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs2050392 1.000 rs2489864 chr10:30693744 C/G cg25182066 chr10:30743637 MAP3K8 -0.38 -5.13 -0.3 5.52e-7 Inflammatory bowel disease; CESC cis rs4764487 0.710 rs7964366 chr12:6346478 T/C cg08284733 chr12:6341482 CD9 0.44 6.52 0.37 3.48e-10 Mean platelet volume; CESC cis rs9039 1.000 rs9921107 chr16:9219845 G/T cg08831531 chr16:9218945 NA -0.44 -6.25 -0.36 1.64e-9 Menopause (age at onset); CESC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.49 -0.37 4.23e-10 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07955105 chr10:27639156 NA -0.51 -6.04 -0.35 5.13e-9 Gut microbiome composition (summer); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg18551892 chr11:86667149 FZD4 -0.45 -6.01 -0.35 5.97e-9 Recombination measurement; CESC cis rs9796 0.870 rs72737704 chr15:41323575 C/G cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.86 -0.39 4.82e-11 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12093930 chr8:82598664 IMPA1 -0.51 -6.67 -0.38 1.45e-10 Fibrinogen levels; CESC cis rs10779751 0.770 rs7553827 chr1:11222393 C/T cg08854313 chr1:11322531 MTOR 0.74 9.18 0.49 1.23e-17 Body mass index; CESC cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.6e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs738322 0.742 rs4821767 chr22:38614129 G/T cg25457927 chr22:38595422 NA 0.29 5.59 0.32 5.63e-8 Cutaneous nevi; CESC cis rs4629180 0.727 rs10188564 chr2:102101064 C/A cg01388757 chr2:102091195 RFX8 -0.45 -6.92 -0.39 3.44e-11 Chronic rhinosinusitis with nasal polyps; CESC cis rs1728785 1.000 rs1170445 chr16:68573064 G/T cg02972257 chr16:68554789 NA -0.55 -6.34 -0.36 9.7e-10 Ulcerative colitis; CESC trans rs4843747 0.671 rs8062855 chr16:88106941 T/C cg26811252 chr16:29126840 RRN3P2 0.67 9.46 0.5 1.77e-18 Menopause (age at onset); CESC cis rs2228479 0.541 rs62052173 chr16:89950739 T/C cg00800038 chr16:89945340 TCF25 -0.64 -7.06 -0.4 1.47e-11 Skin colour saturation; CESC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.53 7.26 0.41 4.38e-12 Lymphocyte counts; CESC trans rs748404 0.631 rs12905772 chr15:43648444 G/A cg24053811 chr14:70265306 SLC10A1 0.43 6.06 0.35 4.72e-9 Lung cancer; CESC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg04553112 chr3:125709451 NA -0.51 -6.2 -0.36 2.2e-9 Blood pressure (smoking interaction); CESC cis rs116095464 0.614 rs62344339 chr5:252995 T/G cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.28 0.31 2.76e-7 Breast cancer; CESC trans rs1728785 1.000 rs4783653 chr16:68562815 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.23 0.41 5.24e-12 Ulcerative colitis; CESC cis rs6912958 0.874 rs2103764 chr6:88157392 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.58 -7.94 -0.44 5.73e-14 Monocyte percentage of white cells; CESC cis rs7089973 0.604 rs11196943 chr10:116598865 T/C cg25233709 chr10:116636983 FAM160B1 0.38 5.97 0.34 7.44e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2130392 1.000 rs2130392 chr4:185639169 A/G cg04058563 chr4:185651563 MLF1IP 0.33 5.15 0.3 5.13e-7 Kawasaki disease; CESC cis rs6696846 0.765 rs61822619 chr1:205090885 C/G cg00857998 chr1:205179979 DSTYK 0.56 7.27 0.41 4.02e-12 Red blood cell count; CESC cis rs3091242 0.935 rs4233043 chr1:25765483 A/G cg27572855 chr1:25598939 RHD 0.44 7.3 0.41 3.27e-12 Erythrocyte sedimentation rate; CESC cis rs963731 0.649 rs2123879 chr2:39292598 A/G cg04010122 chr2:39346883 SOS1 -0.87 -6.01 -0.35 5.99e-9 Corticobasal degeneration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05942963 chr14:71787552 NA 0.61 7.27 0.41 3.98e-12 Gut microbiome composition (summer); CESC trans rs61931739 0.500 rs6488224 chr12:34537205 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 8.03e-13 Morning vs. evening chronotype; CESC cis rs7216064 1.000 rs4791212 chr17:65975385 C/T cg12091567 chr17:66097778 LOC651250 -0.83 -8.76 -0.47 2.3e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs858239 0.600 rs6961131 chr7:23134790 A/G cg23682824 chr7:23144976 KLHL7 0.55 7.67 0.43 3.39e-13 Cerebrospinal fluid biomarker levels; CESC cis rs477692 0.673 rs10829600 chr10:131322051 G/C cg05714579 chr10:131428358 MGMT 0.41 5.27 0.31 2.78e-7 Response to temozolomide; CESC cis rs4595586 0.545 rs12812750 chr12:39363258 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.23 0.41 5.29e-12 Morning vs. evening chronotype; CESC cis rs12995491 0.933 rs13008732 chr2:88528771 G/A cg14558114 chr2:88469736 THNSL2 -0.49 -7.1 -0.4 1.17e-11 Response to metformin (IC50); CESC cis rs2074585 0.517 rs11635361 chr15:91081791 G/T cg22089800 chr15:90895588 ZNF774 -0.43 -5.12 -0.3 5.77e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC trans rs116095464 0.558 rs2288458 chr5:231260 C/T cg00938859 chr5:1591904 SDHAP3 0.63 6.87 0.39 4.48e-11 Breast cancer; CESC cis rs17376456 0.825 rs66564678 chr5:93165894 C/T cg25358565 chr5:93447407 FAM172A 1.12 10.9 0.56 4.36e-23 Diabetic retinopathy; CESC cis rs116161686 0.500 rs55871867 chr1:210051029 A/G cg23283495 chr1:209979779 IRF6 0.48 5.28 0.31 2.71e-7 Coronary artery disease; CESC cis rs595982 0.546 rs9941490 chr19:49396737 G/A cg21252483 chr19:49399788 TULP2 -0.39 -5.63 -0.33 4.59e-8 Red cell distribution width; CESC trans rs2235573 0.551 rs139892 chr22:38388203 C/T cg19894588 chr14:64061835 NA 0.61 8.06 0.44 2.68e-14 Glioblastoma;Glioma; CESC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg16606324 chr3:10149918 C3orf24 0.43 5.36 0.31 1.81e-7 Alzheimer's disease; CESC cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs5769765 0.730 rs62233964 chr22:50317410 C/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.64 -6.54 -0.37 3.14e-10 Schizophrenia; CESC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg14829155 chr15:31115871 NA -0.69 -9.13 -0.49 1.78e-17 Huntington's disease progression; CESC cis rs11792861 0.781 rs2297581 chr9:111755008 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 6.66 0.38 1.55e-10 Menarche (age at onset); CESC cis rs7542091 0.637 rs9429826 chr1:210052146 G/A cg09509183 chr1:209979624 IRF6 0.38 5.45 0.32 1.14e-7 Monobrow; CESC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.63 8.35 0.46 3.94e-15 Height; CESC cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.75 -0.47 2.6e-16 Total body bone mineral density; CESC cis rs2573652 0.722 rs11630930 chr15:100544145 G/T cg09918751 chr15:100517450 ADAMTS17 -0.33 -6.14 -0.35 3.08e-9 Height; CESC cis rs9309473 0.583 rs35885918 chr2:73612234 T/C cg20560298 chr2:73613845 ALMS1 -0.47 -6.49 -0.37 4.22e-10 Metabolite levels; CESC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg05368731 chr17:41323189 NBR1 0.77 10.64 0.55 2.93e-22 Menopause (age at onset); CESC cis rs6032067 0.929 rs17424578 chr20:43806321 A/G cg11264863 chr20:43835661 SEMG1 0.5 5.56 0.32 6.58e-8 Blood protein levels; CESC cis rs12824058 0.798 rs7968728 chr12:130804696 T/A cg24838063 chr12:130822603 PIWIL1 0.61 7.96 0.44 5.22e-14 Menopause (age at onset); CESC cis rs78456975 1.000 rs13413356 chr2:1553849 G/T cg26248373 chr2:1572462 NA -0.59 -5.69 -0.33 3.31e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg01570182 chr17:44337453 NA -0.62 -8.47 -0.46 1.71e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs1814175 0.616 rs1722001 chr11:49894427 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.51e-9 Height; CESC cis rs6987853 0.787 rs2923402 chr8:42445400 G/A cg09913449 chr8:42400586 C8orf40 0.46 7.87 0.44 9.25e-14 Mean corpuscular hemoglobin concentration; CESC cis rs9543976 0.623 rs3783028 chr13:76165282 T/C cg01531495 chr13:76123901 UCHL3 0.5 5.03 0.3 9.04e-7 Diabetic retinopathy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10452522 chr19:34663544 LSM14A 0.49 6.57 0.37 2.63e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg14780466 chr2:20870812 GDF7 -0.47 -7.65 -0.43 3.78e-13 Abdominal aortic aneurysm; CESC cis rs8114671 0.662 rs3761143 chr20:33545745 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.06 0.3 7.9e-7 Height; CESC cis rs73206853 0.764 rs73194012 chr12:111100627 T/C cg12870014 chr12:110450643 ANKRD13A 0.63 5.24 0.31 3.21e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs57221529 0.709 rs4957056 chr5:570105 T/C cg25482853 chr8:67687455 SGK3 1.05 10.55 0.54 6.01e-22 Lung disease severity in cystic fibrosis; CESC cis rs11785400 0.793 rs4430070 chr8:143729184 G/C cg10596483 chr8:143751796 JRK 0.42 5.25 0.31 3.11e-7 Schizophrenia; CESC cis rs67460515 0.531 rs13060601 chr3:160823159 G/A cg03342759 chr3:160939853 NMD3 -0.51 -6.44 -0.37 5.65e-10 Parkinson's disease; CESC cis rs1550582 0.662 rs7812708 chr8:135500832 C/T cg17885191 chr8:135476712 NA 0.85 11.36 0.57 1.23e-24 Educational attainment; CESC cis rs12586317 0.547 rs28395170 chr14:35506988 C/T cg05294307 chr14:35346193 BAZ1A -0.54 -5.54 -0.32 7.14e-8 Psoriasis; CESC cis rs36051895 0.659 rs10974944 chr9:5070831 C/G cg02405213 chr9:5042618 JAK2 -0.52 -6.38 -0.36 8.06e-10 Pediatric autoimmune diseases; CESC cis rs10791323 0.582 rs2851120 chr11:133708065 A/G cg06766960 chr11:133703094 NA -0.37 -5.42 -0.32 1.31e-7 Childhood ear infection; CESC cis rs74781061 0.860 rs8033841 chr15:74763881 A/T cg17294928 chr15:75287854 SCAMP5 -0.5 -5.51 -0.32 8.65e-8 Endometriosis; CESC cis rs12477438 0.520 rs6542863 chr2:99725138 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.61 0.69 2.15e-39 Chronic sinus infection; CESC cis rs3820928 1.000 rs7579961 chr2:227776976 T/A cg05526886 chr2:227700861 RHBDD1 -0.44 -5.75 -0.33 2.45e-8 Pulmonary function; CESC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.23 0.53 6.6e-21 Prudent dietary pattern; CESC cis rs4588572 0.643 rs1864172 chr5:77690945 T/C cg11547950 chr5:77652471 NA 0.45 5.71 0.33 3.06e-8 Triglycerides; CESC cis rs796364 0.625 rs13035260 chr2:201132377 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.48 -5.05 -0.3 8.19e-7 Schizophrenia; CESC cis rs6582630 0.519 rs4436613 chr12:38293653 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.88 0.34 1.26e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9916302 0.904 rs8068427 chr17:37511517 G/A cg20243544 chr17:37824526 PNMT -0.47 -5.74 -0.33 2.54e-8 Glomerular filtration rate (creatinine); CESC cis rs2637266 1.000 rs6480827 chr10:78356333 T/G cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs9915657 0.660 rs1558748 chr17:70066502 T/C cg09344028 chr17:70110421 NA 0.39 7.1 0.4 1.16e-11 Thyroid hormone levels; CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg10150615 chr22:24372951 LOC391322 -0.53 -6.97 -0.39 2.44e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6088590 0.561 rs6087605 chr20:33180624 G/T cg06115741 chr20:33292138 TP53INP2 0.51 6.53 0.37 3.37e-10 Coronary artery disease; CESC cis rs6142102 0.580 rs761233 chr20:32568886 A/G cg08999081 chr20:33150536 PIGU 0.33 5.08 0.3 6.97e-7 Skin pigmentation; CESC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg04546413 chr19:29218101 NA 0.56 7.91 0.44 6.84e-14 Methadone dose in opioid dependence; CESC trans rs57221529 0.766 rs72703042 chr5:579269 C/T cg25482853 chr8:67687455 SGK3 1.01 10.05 0.53 2.35e-20 Lung disease severity in cystic fibrosis; CESC cis rs2274273 1.000 rs57970196 chr14:55600405 C/T cg04306507 chr14:55594613 LGALS3 0.29 5.16 0.3 4.74e-7 Protein biomarker; CESC cis rs9549260 0.755 rs2297627 chr13:41233931 A/G cg21288729 chr13:41239152 FOXO1 0.66 8.42 0.46 2.36e-15 Red blood cell count; CESC cis rs523522 0.962 rs10744752 chr12:120900554 T/G cg27279351 chr12:120934652 DYNLL1 0.68 8.42 0.46 2.45e-15 High light scatter reticulocyte count; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16139770 chr10:63661496 ARID5B 0.48 6.1 0.35 3.73e-9 Systemic lupus erythematosus; CESC cis rs8180040 0.835 rs6780013 chr3:47452118 G/A cg27129171 chr3:47204927 SETD2 -0.63 -9.4 -0.5 2.63e-18 Colorectal cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20851245 chr2:219538212 STK36;RNF25 -0.4 -6.74 -0.38 9.72e-11 Gambling; CESC cis rs116095464 0.558 rs10065239 chr5:275288 C/T cg22496380 chr5:211416 CCDC127 -0.97 -9.97 -0.52 4.23e-20 Breast cancer; CESC cis rs3733585 0.805 rs882222 chr4:9981294 G/A cg00071950 chr4:10020882 SLC2A9 0.78 14.43 0.66 3.07e-35 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9302635 0.513 rs7198572 chr16:72183220 G/A cg01557791 chr16:72042693 DHODH -0.63 -7.12 -0.4 1.04e-11 Blood protein levels; CESC trans rs7726839 0.540 rs74553517 chr5:665671 C/T cg25482853 chr8:67687455 SGK3 0.97 9.73 0.51 2.43e-19 Obesity-related traits; CESC cis rs763014 0.931 rs62030903 chr16:638323 T/A cg00802000 chr16:706648 WDR90 -0.37 -5.36 -0.31 1.82e-7 Height; CESC cis rs2070488 0.775 rs9838614 chr3:38537671 A/C cg24069376 chr3:38537580 EXOG -0.3 -5.09 -0.3 6.76e-7 Electrocardiographic conduction measures; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16572859 chr19:18263815 PIK3R2 -0.46 -6.67 -0.38 1.47e-10 Fibrinogen levels; CESC cis rs7959452 0.530 rs12811632 chr12:69755003 G/A cg14784868 chr12:69753453 YEATS4 0.83 12.85 0.62 1.03e-29 Blood protein levels; CESC cis rs9611565 0.559 rs132765 chr22:42008068 A/G cg06481639 chr22:41940642 POLR3H 0.62 6.24 0.36 1.7e-9 Vitiligo; CESC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg18230493 chr5:56204884 C5orf35 -0.66 -8.28 -0.45 6.32e-15 Initial pursuit acceleration; CESC cis rs12220238 1.000 rs10762582 chr10:75968316 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.44 0.32 1.24e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs10782582 0.593 rs6675212 chr1:76230829 C/A cg10523679 chr1:76189770 ACADM -0.47 -5.45 -0.32 1.18e-7 Daytime sleep phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19304273 chr11:49070231 NA -0.44 -6.02 -0.35 5.75e-9 Gut microbiome composition (summer); CESC cis rs6032067 0.929 rs6017513 chr20:43835232 A/C cg10761708 chr20:43804764 PI3 0.5 5.94 0.34 8.83e-9 Blood protein levels; CESC cis rs11122272 0.735 rs2486733 chr1:231531465 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg18876405 chr7:65276391 NA 0.47 5.3 0.31 2.45e-7 Aortic root size; CESC cis rs4822044 0.680 rs8138780 chr22:42097462 A/T cg06481639 chr22:41940642 POLR3H 0.59 5.91 0.34 1.05e-8 Cannabis dependence symptom count; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg13964393 chr15:45003702 B2M -0.44 -6.06 -0.35 4.65e-9 Asthma; CESC cis rs8044868 0.530 rs2550868 chr16:72066072 G/A cg16558253 chr16:72132732 DHX38 -0.4 -6.13 -0.35 3.24e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg17372223 chr3:52568218 NT5DC2 0.4 5.93 0.34 9.47e-9 Bipolar disorder; CESC cis rs1595825 0.786 rs77773624 chr2:198514845 G/A cg10820045 chr2:198174542 NA 0.42 5.29 0.31 2.54e-7 Ulcerative colitis; CESC cis rs9915657 0.870 rs12600458 chr17:70130545 C/T cg06234051 chr17:70120541 SOX9 -0.44 -6.43 -0.37 6.05e-10 Thyroid hormone levels; CESC cis rs854765 0.583 rs12452254 chr17:17829434 G/A cg09796270 chr17:17721594 SREBF1 0.46 6.42 0.37 6.23e-10 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18502522 chr15:75165624 SCAMP2 0.55 6.4 0.37 6.88e-10 Gut microbiome composition (summer); CESC cis rs36051895 0.664 rs10115518 chr9:5094559 T/C cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.61e-9 Pediatric autoimmune diseases; CESC cis rs9457247 1.000 rs932644 chr6:167404187 A/C cg07741184 chr6:167504864 NA 0.28 5.1 0.3 6.54e-7 Crohn's disease; CESC cis rs7809950 1.000 rs28714607 chr7:107106253 T/C cg23024343 chr7:107201750 COG5 -0.44 -6.24 -0.36 1.76e-9 Coronary artery disease; CESC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg18876405 chr7:65276391 NA 0.52 6.87 0.39 4.49e-11 Aortic root size; CESC cis rs9486719 1.000 rs11153064 chr6:97021959 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -8.28 -0.45 6.29e-15 Migraine;Coronary artery disease; CESC cis rs6032067 0.704 rs35009666 chr20:43786020 C/T cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs12900413 0.687 rs35060998 chr15:90310294 A/G cg24249390 chr15:90295951 MESP1 -0.4 -5.5 -0.32 9.05e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs58785573 0.504 rs62294474 chr4:38628725 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.46 6.29 0.36 1.3e-9 Lymphocyte percentage of white cells; CESC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg00149659 chr3:10157352 C3orf10 0.7 8.7 0.47 3.6e-16 Alzheimer's disease; CESC cis rs2075371 0.897 rs10488428 chr7:133997560 C/T cg11752832 chr7:134001865 SLC35B4 0.52 6.66 0.38 1.6e-10 Mean platelet volume; CESC cis rs2777491 0.957 rs3743038 chr15:41694743 C/T cg20272979 chr15:41787780 ITPKA 0.43 6.38 0.36 7.81e-10 Ulcerative colitis; CESC cis rs6493487 0.512 rs12913094 chr15:51219284 T/C cg02338191 chr15:51200825 AP4E1 0.62 5.84 0.34 1.52e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7666738 0.515 rs13118898 chr4:98792893 T/A cg17366294 chr4:99064904 C4orf37 0.52 6.61 0.38 2.09e-10 Colonoscopy-negative controls vs population controls; CESC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg11941060 chr3:133502564 NA -0.46 -6.22 -0.36 1.93e-9 Iron status biomarkers; CESC cis rs2439831 0.681 rs3742971 chr15:43622916 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.89 -13.8 -0.65 5.02e-33 Lung cancer in ever smokers; CESC cis rs60154123 0.730 rs689248 chr1:210463122 A/G cg21951975 chr1:209979733 IRF6 -0.48 -6.61 -0.38 2.16e-10 Coronary artery disease; CESC cis rs3859192 0.599 rs2270401 chr17:38176256 A/T cg17344932 chr17:38183730 MED24;SNORD124 0.62 9.17 0.49 1.33e-17 White blood cell count; CESC cis rs1879734 0.689 rs12040081 chr1:54168609 A/G cg23596471 chr1:54105337 GLIS1 0.35 5.58 0.32 5.97e-8 Mitral valve prolapse; CESC cis rs7264396 0.690 rs2425172 chr20:34443893 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -11.72 -0.58 7.57e-26 Total cholesterol levels; CESC cis rs911555 0.755 rs12435516 chr14:103954404 T/C cg12935359 chr14:103987150 CKB 0.67 9.78 0.52 1.73e-19 Intelligence (multi-trait analysis); CESC cis rs7772486 0.686 rs9373473 chr6:146082282 A/G cg05347473 chr6:146136440 FBXO30 0.46 6.12 0.35 3.38e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs11997175 0.545 rs66783231 chr8:33811467 A/T ch.8.33884649F chr8:33765107 NA 0.47 6.04 0.35 5.27e-9 Body mass index; CESC cis rs9532580 0.778 rs61963319 chr13:41244220 A/T cg21288729 chr13:41239152 FOXO1 0.68 8.46 0.46 1.82e-15 Mean corpuscular hemoglobin; CESC cis rs933688 1.000 rs2059208 chr5:90732065 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.12 15.6 0.69 2.34e-39 Smoking behavior; CESC cis rs763014 0.931 rs1981483 chr16:630665 G/A cg07343612 chr16:622815 PIGQ -0.58 -8.49 -0.46 1.53e-15 Height; CESC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.2 -0.36 2.21e-9 Parkinson's disease; CESC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg08859206 chr1:53392774 SCP2 0.61 9.01 0.48 4.28e-17 Monocyte count; CESC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs9910055 0.509 rs9916444 chr17:42313512 C/G cg19774624 chr17:42201019 HDAC5 -0.55 -7.36 -0.41 2.33e-12 Total body bone mineral density; CESC cis rs3540 0.513 rs2589974 chr15:90891566 C/T cg10434728 chr15:90938212 IQGAP1 -0.38 -6.64 -0.38 1.75e-10 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1881797 0.872 rs12408686 chr1:247691141 C/T cg05639522 chr1:247681581 NA 0.48 6.22 0.36 1.92e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.51 -5.5 -0.32 8.78e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs208520 0.690 rs6929762 chr6:66709277 C/T cg07460842 chr6:66804631 NA 0.97 13.04 0.63 2.3e-30 Exhaled nitric oxide output; CESC cis rs11642862 1.000 rs113454775 chr16:30809534 A/G cg02466173 chr16:30829666 NA -0.59 -5.92 -0.34 9.76e-9 Tonsillectomy; CESC trans rs11098499 0.863 rs10009626 chr4:120470005 T/C cg25214090 chr10:38739885 LOC399744 0.67 9.21 0.49 1.05e-17 Corneal astigmatism; CESC cis rs6429082 0.818 rs210037 chr1:235649501 A/G cg26050004 chr1:235667680 B3GALNT2 0.63 7.82 0.43 1.24e-13 Adiposity; CESC cis rs6736093 0.862 rs35382200 chr2:112780716 G/C cg12686935 chr2:112915763 FBLN7 -0.41 -5.33 -0.31 2.1e-7 Coronary artery disease; CESC cis rs1153858 1.000 rs12595087 chr15:45655232 A/G cg14582100 chr15:45693742 SPATA5L1 0.42 5.96 0.34 7.92e-9 Homoarginine levels; CESC cis rs3204270 0.810 rs8077959 chr17:79670122 G/A cg18367735 chr17:79674897 NA 0.66 5.48 0.32 1.01e-7 Dental caries; CESC cis rs7523050 0.643 rs36052234 chr1:109402943 C/T cg08274380 chr1:109419600 GPSM2 0.86 5.69 0.33 3.36e-8 Fat distribution (HIV); CESC cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg26597838 chr10:835615 NA 0.85 8.99 0.48 4.92e-17 Eosinophil percentage of granulocytes; CESC cis rs6500602 0.964 rs2304633 chr16:4496973 T/A cg08645402 chr16:4508243 NA 0.44 6.71 0.38 1.14e-10 Schizophrenia; CESC cis rs807669 0.777 rs9605972 chr22:19253274 C/T cg02655711 chr22:19163373 SLC25A1 0.58 8.39 0.46 2.88e-15 Metabolite levels; CESC cis rs208520 0.690 rs851465 chr6:66840293 G/A cg07460842 chr6:66804631 NA -0.99 -13.42 -0.64 1.15e-31 Exhaled nitric oxide output; CESC cis rs9291683 0.530 rs13115193 chr4:9982191 C/T cg00071950 chr4:10020882 SLC2A9 0.78 14.43 0.66 3.07e-35 Bone mineral density; CESC cis rs9549367 0.789 rs34989271 chr13:113894766 G/A cg18105134 chr13:113819100 PROZ -0.67 -8.13 -0.45 1.68e-14 Platelet distribution width; CESC cis rs2367563 1.000 rs2367563 chr12:96057184 A/G cg19013339 chr12:96052514 NTN4 0.37 5.4 0.31 1.47e-7 Allergic dermatitis (nickel); CESC cis rs1215050 0.740 rs700740 chr4:98976003 A/C cg05340658 chr4:99064831 C4orf37 -0.56 -7.55 -0.42 7e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs3820068 0.581 rs72645874 chr1:15926238 C/G cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs8112211 0.598 rs4802351 chr19:38848796 A/G cg14299480 chr19:38876666 GGN -0.49 -5.58 -0.32 6.04e-8 Blood protein levels; CESC cis rs9611565 0.592 rs4822040 chr22:41963553 C/G cg06634786 chr22:41940651 POLR3H -0.63 -6.9 -0.39 3.9e-11 Vitiligo; CESC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.71 0.62 3.17e-29 Personality dimensions; CESC cis rs1376303 0.558 rs41479949 chr7:32946363 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.64 -5.09 -0.3 6.84e-7 Intelligence (multi-trait analysis); CESC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg11663144 chr21:46675770 NA -0.61 -9.6 -0.51 6.2e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11098499 0.863 rs34308924 chr4:120481431 T/C cg25214090 chr10:38739885 LOC399744 0.66 9.03 0.49 3.57e-17 Corneal astigmatism; CESC trans rs875971 1.000 rs1968225 chr7:65874773 T/C cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.77e-9 Aortic root size; CESC cis rs9902453 0.838 rs9646437 chr17:28209065 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.08 0.44 2.31e-14 Coffee consumption (cups per day); CESC cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7561273 0.586 rs11902756 chr2:24300932 A/G cg20701182 chr2:24300061 SF3B14 0.52 6.69 0.38 1.34e-10 Quantitative traits; CESC cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg12386194 chr3:101231763 SENP7 -0.61 -6.41 -0.37 6.48e-10 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg07701084 chr6:150067640 NUP43 0.47 6.6 0.38 2.17e-10 Lung cancer; CESC cis rs2243480 1.000 rs316321 chr7:65611613 G/A cg13147721 chr7:65941812 NA -0.97 -9.14 -0.49 1.7e-17 Diabetic kidney disease; CESC cis rs2795502 0.702 rs3123750 chr10:43227824 C/A cg20628663 chr10:43360327 NA -0.65 -6.95 -0.39 2.76e-11 Blood protein levels; CESC cis rs6500602 0.701 rs4785971 chr16:4577090 A/G cg08645402 chr16:4508243 NA 0.4 5.63 0.33 4.56e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19906608 chr1:94344521 DNTTIP2 0.67 7.86 0.43 9.47e-14 Gut microbiome composition (summer); CESC cis rs4654899 0.965 rs2873424 chr1:21500701 C/A cg05370193 chr1:21551575 ECE1 0.39 5.77 0.33 2.19e-8 Superior frontal gyrus grey matter volume; CESC cis rs4844614 1.000 rs4844614 chr1:207875175 G/T cg21110645 chr1:207815933 NA 0.35 5.44 0.32 1.24e-7 LDL cholesterol; CESC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg24209194 chr3:40518798 ZNF619 0.5 6.62 0.38 1.97e-10 Renal cell carcinoma; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg12271800 chr19:59028764 ZBTB45 -0.49 -6.68 -0.38 1.36e-10 Breast cancer;Type 2 diabetes; CESC cis rs1008375 0.872 rs6831115 chr4:17640463 A/G cg15017067 chr4:17643749 FAM184B 0.36 5.11 0.3 6.3e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7605827 0.930 rs1318980 chr2:15549890 G/T cg19274914 chr2:15703543 NA 0.36 6.56 0.37 2.83e-10 Educational attainment (years of education); CESC cis rs9925964 0.935 rs12597511 chr16:31145219 C/T cg02466173 chr16:30829666 NA 0.33 5.07 0.3 7.51e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg02569458 chr12:86230093 RASSF9 0.51 7.64 0.42 3.9e-13 Major depressive disorder; CESC cis rs9291683 0.668 rs2241474 chr4:10086015 T/C cg00071950 chr4:10020882 SLC2A9 0.7 10.92 0.56 3.72e-23 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06782493 chr16:1876874 HAGH;FAHD1 0.64 8.02 0.44 3.37e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21449445 chr8:144546357 ZC3H3 -0.6 -7.1 -0.4 1.12e-11 Gut microbiome composition (summer); CESC cis rs9486715 0.867 rs11152924 chr6:96877383 A/G cg06623918 chr6:96969491 KIAA0776 0.91 14.05 0.65 6.83e-34 Headache; CESC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg11890956 chr21:40555474 PSMG1 -0.67 -9.54 -0.51 1e-18 Menarche (age at onset); CESC cis rs6546550 0.867 rs4852349 chr2:70076954 A/T cg02498382 chr2:70120550 SNRNP27 -0.37 -6.28 -0.36 1.41e-9 Prevalent atrial fibrillation; CESC cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg23583168 chr7:148888333 NA 0.76 11.49 0.58 4.59e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7264396 0.635 rs2064724 chr20:34522520 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -11.03 -0.56 1.57e-23 Total cholesterol levels; CESC cis rs425277 0.565 rs61775448 chr1:2045376 A/G cg16545954 chr1:2118288 C1orf86 -0.32 -5.98 -0.34 7.26e-9 Height; CESC cis rs62229266 0.771 rs2835232 chr21:37393427 G/A cg12218747 chr21:37451666 NA -0.4 -5.71 -0.33 3.01e-8 Mitral valve prolapse; CESC cis rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00777555 chr3:57583074 ARF4 0.38 5.03 0.3 9.01e-7 Systemic lupus erythematosus; CESC cis rs16866061 1.000 rs72974205 chr2:225408468 C/T cg12698349 chr2:225449008 CUL3 0.76 11.28 0.57 2.38e-24 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs7274811 0.744 rs6141962 chr20:32110312 T/C cg21523528 chr20:32077966 CBFA2T2 0.62 7.13 0.4 9.62e-12 Height; CESC cis rs7264396 0.635 rs6058382 chr20:34553948 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.29 -0.53 4.22e-21 Total cholesterol levels; CESC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg12463550 chr7:65579703 CRCP 0.56 7.07 0.4 1.39e-11 Aortic root size; CESC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.51 0.37 3.65e-10 Prudent dietary pattern; CESC cis rs72781680 0.752 rs12616649 chr2:23890913 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.58 0.37 2.44e-10 Lymphocyte counts; CESC cis rs4253772 0.550 rs738444 chr22:46721088 C/T cg24881330 chr22:46731750 TRMU 0.91 10.0 0.52 3.44e-20 LDL cholesterol;Cholesterol, total; CESC cis rs10751667 0.560 rs7924794 chr11:962745 A/T cg06064525 chr11:970664 AP2A2 -0.48 -9.43 -0.5 2.11e-18 Alzheimer's disease (late onset); CESC trans rs10448044 0.956 rs10448042 chr8:80101677 A/G cg08211306 chr6:46097784 ENPP4 0.42 6.08 0.35 4.2e-9 Suicide in bipolar disorder; CESC trans rs9951602 0.512 rs58352488 chr18:76651113 T/A cg02800362 chr5:177631904 HNRNPAB 0.66 8.66 0.47 4.55e-16 Obesity-related traits; CESC cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg13902645 chr11:5959945 NA -0.62 -7.34 -0.41 2.65e-12 DNA methylation (variation); CESC cis rs2486288 0.656 rs11629859 chr15:45547121 T/G cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.5 -0.37 4.05e-10 Glomerular filtration rate; CESC cis rs922182 0.633 rs12592702 chr15:64271882 C/T cg24729988 chr15:64271149 DAPK2 -0.47 -6.72 -0.38 1.08e-10 Blood protein levels; CESC cis rs7666738 0.606 rs6839946 chr4:99076132 A/C cg03467027 chr4:99064603 C4orf37 0.41 5.09 0.3 6.89e-7 Colonoscopy-negative controls vs population controls; CESC trans rs7690543 0.505 rs1364981 chr4:67995183 G/A cg05505961 chr17:66375071 ARSG -0.51 -6.1 -0.35 3.79e-9 Glucose homeostasis traits; CESC cis rs9512730 0.553 rs6491211 chr13:28049533 A/G cg04070771 chr13:27998621 GTF3A 0.44 5.03 0.3 9.06e-7 Schizophrenia; CESC cis rs13256369 1.000 rs4840351 chr8:8573148 A/G cg17143192 chr8:8559678 CLDN23 0.73 8.6 0.47 7.31e-16 Obesity-related traits; CESC cis rs1538970 0.781 rs713358 chr1:45988267 C/G cg03146154 chr1:46216737 IPP 0.45 5.27 0.31 2.79e-7 Platelet count; CESC cis rs7116495 1.000 rs4945426 chr11:71748146 A/C cg10381502 chr11:71823885 C11orf51 0.62 5.39 0.31 1.55e-7 Severe influenza A (H1N1) infection; CESC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg24675658 chr1:53192096 ZYG11B -0.7 -9.41 -0.5 2.53e-18 Monocyte count; CESC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg14298792 chr15:30685198 CHRFAM7A -0.47 -5.62 -0.33 4.81e-8 Huntington's disease progression; CESC cis rs1865760 0.532 rs2006736 chr6:26086017 C/T cg16482183 chr6:26056742 HIST1H1C 0.38 5.11 0.3 6.19e-7 Height; CESC cis rs501120 0.810 rs622472 chr10:44749211 A/C cg09554077 chr10:44749378 NA 0.48 6.2 0.36 2.13e-9 Coronary artery disease;Coronary heart disease; CESC cis rs6570726 0.905 rs1355146 chr6:145781741 A/C cg23711669 chr6:146136114 FBXO30 -0.73 -10.7 -0.55 1.96e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs2708240 0.540 rs1723438 chr7:147546659 G/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.37 -5.62 -0.33 4.84e-8 QT interval (drug interaction); CESC cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs4808199 0.901 rs12973258 chr19:19488718 T/C cg03709012 chr19:19516395 GATAD2A 1.13 13.1 0.63 1.44e-30 Nonalcoholic fatty liver disease; CESC cis rs2180341 0.960 rs7753913 chr6:127671296 A/G cg24812749 chr6:127587940 RNF146 1.05 15.07 0.68 1.77e-37 Breast cancer; CESC cis rs2857078 0.745 rs4793085 chr17:42320732 A/C cg13607699 chr17:42295918 UBTF -0.78 -11.22 -0.57 3.61e-24 Red cell distribution width;Reticulocyte count; CESC cis rs9300255 0.602 rs1727296 chr12:123647725 G/C cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.16e-16 Neutrophil percentage of white cells; CESC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg02772935 chr3:125709198 NA -0.44 -5.48 -0.32 1.01e-7 Blood pressure (smoking interaction); CESC cis rs2731664 0.792 rs335434 chr5:176867276 A/G cg23176889 chr5:176863531 GRK6 -0.61 -9.79 -0.52 1.58e-19 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03411949 chr12:62654125 USP15 0.58 6.07 0.35 4.32e-9 Gut microbiome composition (summer); CESC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg16006841 chr5:176797999 RGS14 0.5 5.21 0.3 3.75e-7 Urinary electrolytes (magnesium/calcium ratio); CESC cis rs3820068 0.581 rs6429762 chr1:15945595 A/C cg13390004 chr1:15929781 NA 0.34 5.61 0.33 5.1e-8 Systolic blood pressure; CESC cis rs116095464 0.558 rs28635197 chr5:279071 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.41 0.32 1.38e-7 Breast cancer; CESC cis rs10276381 1.000 rs10280937 chr7:28182306 T/C cg23620719 chr7:28220237 JAZF1 0.7 7.22 0.41 5.61e-12 Crohn's disease; CESC cis rs6762 0.748 rs7928935 chr11:839127 G/A cg23754390 chr11:835074 CD151 0.32 5.51 0.32 8.52e-8 Mean platelet volume; CESC cis rs920590 0.758 rs2898491 chr8:19661883 C/T cg17834443 chr8:19674713 INTS10 0.58 6.53 0.37 3.27e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs920590 0.758 rs1907799 chr8:19664668 A/G cg03894339 chr8:19674705 INTS10 -0.6 -7.14 -0.4 9.02e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs9486719 1.000 rs72931061 chr6:96880285 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs8072100 0.745 rs7214410 chr17:45422628 A/G cg08085267 chr17:45401833 C17orf57 -0.55 -7.4 -0.41 1.83e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6088590 1.000 rs6087626 chr20:33347328 C/T cg24642439 chr20:33292090 TP53INP2 0.84 11.78 0.59 4.81e-26 Coronary artery disease; CESC cis rs116979167 0.630 rs56230603 chr7:105165268 A/G cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs992157 0.687 rs35271699 chr2:219117482 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.67 9.13 0.49 1.79e-17 Colorectal cancer; CESC cis rs116095464 0.558 rs2288457 chr5:231270 C/T cg10591111 chr5:226296 SDHA -0.51 -6.18 -0.35 2.44e-9 Breast cancer; CESC cis rs7527798 0.545 rs6696228 chr1:207846830 G/A cg21110645 chr1:207815933 NA -0.33 -5.67 -0.33 3.7e-8 Erythrocyte sedimentation rate; CESC cis rs523522 0.962 rs4767904 chr12:120930798 T/G cg27279351 chr12:120934652 DYNLL1 0.69 8.95 0.48 6.15e-17 High light scatter reticulocyte count; CESC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg17971929 chr21:40555470 PSMG1 -0.86 -12.45 -0.61 2.59e-28 Cognitive function; CESC cis rs3733585 0.699 rs2018643 chr4:9947121 C/T cg00071950 chr4:10020882 SLC2A9 0.71 11.71 0.58 8.25e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10911251 0.546 rs1547715 chr1:183113952 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.22 0.63 5.53e-31 Colorectal cancer; CESC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg15112475 chr7:1198522 ZFAND2A -0.39 -6.13 -0.35 3.2e-9 Longevity;Endometriosis; CESC cis rs2228479 1.000 rs2228479 chr16:89985940 G/A cg00800038 chr16:89945340 TCF25 -0.92 -7.43 -0.42 1.48e-12 Skin colour saturation; CESC cis rs10089 1.000 rs11957052 chr5:127524055 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 9.52 0.5 1.14e-18 Ileal carcinoids; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10972625 chr1:143745140 LOC100286793;FLJ39739 -0.58 -7.26 -0.41 4.22e-12 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs1638734 chr7:66097539 A/C cg13147721 chr7:65941812 NA -0.91 -8.45 -0.46 1.99e-15 Diabetic kidney disease; CESC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg04025307 chr7:1156635 C7orf50 0.54 9.01 0.48 4.22e-17 Longevity;Endometriosis; CESC cis rs7267979 0.932 rs2387891 chr20:25470328 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.74 13.2 0.63 6.56e-31 Liver enzyme levels (alkaline phosphatase); CESC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg06456125 chr7:65229604 NA 0.45 5.94 0.34 8.7e-9 Aortic root size; CESC cis rs11696501 0.688 rs6094197 chr20:44316492 C/T cg11783356 chr20:44313418 WFDC10B -0.31 -5.08 -0.3 7.02e-7 Brain structure; CESC trans rs2727020 0.523 rs7948958 chr11:49506749 G/A cg03929089 chr4:120376271 NA 0.7 7.98 0.44 4.31e-14 Coronary artery disease; CESC cis rs919433 0.680 rs3792160 chr2:198403519 G/A cg03934865 chr2:198174659 NA 0.38 5.06 0.3 7.92e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs921968 0.540 rs7582329 chr2:219620909 C/T cg02176678 chr2:219576539 TTLL4 -0.44 -7.67 -0.43 3.29e-13 Mean corpuscular hemoglobin concentration; CESC cis rs10465746 0.967 rs6576956 chr1:84343885 T/G cg10977910 chr1:84465055 TTLL7 0.48 6.52 0.37 3.64e-10 Obesity-related traits; CESC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg08470875 chr2:26401718 FAM59B 0.69 6.74 0.38 1.01e-10 Gut microbiome composition (summer); CESC cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg18225595 chr11:63971243 STIP1 -0.64 -8.95 -0.48 6.28e-17 Platelet count; CESC cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg20243544 chr17:37824526 PNMT -0.45 -5.62 -0.33 4.75e-8 Glomerular filtration rate (creatinine); CESC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.72 6.41 0.37 6.71e-10 Platelet count; CESC trans rs1005277 0.540 rs7903942 chr10:37929276 C/T cg12057190 chr19:54976211 LENG9;CDC42EP5 -0.42 -6.1 -0.35 3.82e-9 Extrinsic epigenetic age acceleration; CESC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg12463550 chr7:65579703 CRCP -0.48 -6.03 -0.35 5.35e-9 Aortic root size; CESC cis rs10493773 0.609 rs6689168 chr1:86174232 G/T cg17807903 chr1:86174739 ZNHIT6 -0.44 -6.53 -0.37 3.37e-10 Urate levels in overweight individuals; CESC trans rs848353 1.000 rs11768295 chr7:108595963 T/C cg03555276 chr13:113260139 NA 0.56 6.03 0.35 5.42e-9 Smoking behavior; CESC cis rs7267979 1.000 rs6050547 chr20:25326012 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.49 -0.32 9.45e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7927771 0.896 rs12794570 chr11:47658314 C/T cg18512352 chr11:47633146 NA -0.62 -9.74 -0.51 2.4e-19 Subjective well-being; CESC cis rs9611565 0.649 rs202666 chr22:41814719 T/C cg03806693 chr22:41940476 POLR3H 1.16 14.61 0.67 7.1e-36 Vitiligo; CESC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg22903471 chr2:27725779 GCKR -0.48 -6.79 -0.38 7.49e-11 Total body bone mineral density; CESC cis rs9831754 0.526 rs6548551 chr3:78342292 C/T cg06138941 chr3:78371609 NA 0.43 5.73 0.33 2.78e-8 Calcium levels; CESC cis rs34779708 0.966 rs4934737 chr10:35512799 T/C cg04310649 chr10:35416472 CREM -0.54 -6.4 -0.37 6.97e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs9291683 0.551 rs2276961 chr4:10022981 C/T cg02734326 chr4:10020555 SLC2A9 0.48 6.82 0.39 6.31e-11 Bone mineral density; CESC cis rs9815354 1.000 rs17063599 chr3:41861676 C/T cg03022575 chr3:42003672 ULK4 0.48 5.38 0.31 1.68e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs2014572 1.000 rs3746231 chr19:57760057 G/A cg12963866 chr19:57752005 ZNF805 -0.47 -6.19 -0.36 2.29e-9 Hyperactive-impulsive symptoms; CESC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg06494592 chr3:125709126 NA -0.51 -5.51 -0.32 8.32e-8 Blood pressure (smoking interaction); CESC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg11494091 chr17:61959527 GH2 -0.79 -13.94 -0.65 1.7e-33 Prudent dietary pattern; CESC cis rs56399783 0.901 rs73049362 chr7:2826822 G/A cg19731401 chr7:2775893 GNA12 0.66 5.9 0.34 1.08e-8 Childhood ear infection; CESC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg16680214 chr1:154839983 KCNN3 -0.45 -6.93 -0.39 3.15e-11 Prostate cancer; CESC cis rs9457247 1.000 rs393558 chr6:167397750 A/C cg25258033 chr6:167368657 RNASET2 0.4 6.12 0.35 3.43e-9 Crohn's disease; CESC cis rs9633740 1.000 rs7896832 chr10:82257570 T/C cg00277334 chr10:82204260 NA -0.58 -5.81 -0.34 1.8e-8 Post bronchodilator FEV1; CESC trans rs61148964 0.826 rs58430765 chr22:37235632 G/A cg05061107 chr11:64532875 SF1 0.62 6.0 0.35 6.63e-9 Scarlet fever; CESC cis rs4919087 0.926 rs2861875 chr10:98990139 C/G cg25902810 chr10:99078978 FRAT1 -0.66 -9.49 -0.5 1.37e-18 Monocyte count; CESC cis rs9649213 0.614 rs9641236 chr7:97998124 T/A cg09267113 chr7:98030324 BAIAP2L1 -0.42 -5.67 -0.33 3.65e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs12618769 0.597 rs4850879 chr2:99113082 A/G cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02447287 chr2:238707023 RBM44 -0.55 -6.07 -0.35 4.39e-9 Gut microbiome composition (summer); CESC cis rs870825 0.655 rs72703561 chr4:185630890 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.0 0.4 2.05e-11 Blood protein levels; CESC cis rs62064224 0.902 rs35830939 chr17:30627564 A/C cg24550644 chr17:30846204 MYO1D -0.35 -5.14 -0.3 5.38e-7 Schizophrenia; CESC trans rs8140097 0.566 rs5993688 chr22:19561066 T/G cg03477303 chr10:134016713 DPYSL4 0.52 6.19 0.36 2.32e-9 Recurrent major depressive disorder; CESC cis rs9291683 0.507 rs6827754 chr4:10018153 A/C cg00071950 chr4:10020882 SLC2A9 -0.67 -9.45 -0.5 1.83e-18 Bone mineral density; CESC cis rs8067354 0.645 rs2132715 chr17:57858374 A/T cg02344993 chr17:57696989 CLTC 0.57 6.21 0.36 2.03e-9 Hemoglobin concentration; CESC cis rs1448094 0.706 rs10863149 chr12:86425498 A/T cg02569458 chr12:86230093 RASSF9 0.38 5.56 0.32 6.46e-8 Major depressive disorder; CESC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.03e-11 Tonsillectomy; CESC cis rs6752107 0.935 rs10199278 chr2:234160669 C/G cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.37 5.74 0.33 2.56e-8 Crohn's disease;Inflammatory bowel disease; CESC trans rs208623 0.774 rs110368 chr16:22943837 C/T cg20295040 chr1:192778396 RGS2 0.52 6.07 0.35 4.31e-9 CTACK levels; CESC cis rs3015497 0.789 rs11621971 chr14:51124527 C/T cg09863266 chr14:51125203 SAV1 0.35 5.51 0.32 8.5e-8 Mean platelet volume; CESC cis rs9287719 0.967 rs4613248 chr2:10744051 C/T cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs4268898 0.662 rs56006260 chr2:24409903 A/G cg06627628 chr2:24431161 ITSN2 -1.01 -10.33 -0.54 3.04e-21 Asthma; CESC cis rs10208940 0.502 rs10203846 chr2:68670921 G/A cg12452813 chr2:68675892 NA -0.74 -9.16 -0.49 1.45e-17 Urate levels in lean individuals; CESC cis rs16917546 1.000 rs10995248 chr10:64396042 A/G cg03961010 chr10:64397487 ZNF365 0.38 6.26 0.36 1.58e-9 Basal cell carcinoma; CESC cis rs2880765 0.835 rs2170736 chr15:86043398 A/G cg10818794 chr15:86012489 AKAP13 -0.34 -5.2 -0.3 4.03e-7 Coronary artery disease; CESC cis rs2050392 0.760 rs10826797 chr10:30690376 A/C cg02070205 chr10:30722105 MAP3K8 -0.44 -5.29 -0.31 2.6e-7 Inflammatory bowel disease; CESC cis rs709400 0.628 rs2273699 chr14:103923475 A/G cg12935359 chr14:103987150 CKB -0.51 -7.41 -0.41 1.71e-12 Body mass index; CESC cis rs4803468 1.000 rs4674 chr19:41930396 A/G cg09537434 chr19:41945824 ATP5SL -1.11 -20.29 -0.78 7.01e-56 Height; CESC cis rs2404602 0.692 rs35999717 chr15:77193367 G/C cg22467129 chr15:76604101 ETFA -0.35 -5.25 -0.31 3.13e-7 Blood metabolite levels; CESC cis rs7824557 0.736 rs35392635 chr8:11164349 G/C cg21775007 chr8:11205619 TDH 0.5 7.3 0.41 3.43e-12 Retinal vascular caliber; CESC cis rs9914988 0.778 rs9907185 chr17:27122414 C/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC trans rs8014252 0.667 rs55728800 chr14:70813520 C/T cg03123320 chr1:229394665 NA -0.49 -6.27 -0.36 1.45e-9 Plasma estrone levels in resected estrogen-receptor positive breast cancer; CESC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.22 0.45 8.86e-15 Menopause (age at onset); CESC cis rs9513627 1.000 rs6491512 chr13:100199741 C/T cg25919922 chr13:100150906 NA 0.65 5.1 0.3 6.62e-7 Obesity-related traits; CESC cis rs4555082 0.834 rs2735822 chr14:105712734 C/T cg13114125 chr14:105738426 BRF1 -0.86 -10.3 -0.53 3.86e-21 Mean platelet volume;Platelet distribution width; CESC cis rs2456568 0.548 rs6483280 chr11:93661592 T/C cg26875233 chr11:93583750 C11orf90 -0.33 -5.87 -0.34 1.3e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs9905704 0.647 rs6503888 chr17:57028126 T/C cg12560992 chr17:57184187 TRIM37 0.61 7.64 0.43 3.87e-13 Testicular germ cell tumor; CESC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg25405998 chr7:65216604 CCT6P1 0.44 5.57 0.32 6.41e-8 Calcium levels; CESC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg25767906 chr1:53392781 SCP2 0.44 6.13 0.35 3.09e-9 Monocyte count; CESC cis rs7560272 0.512 rs13015885 chr2:73920482 G/T cg20560298 chr2:73613845 ALMS1 0.45 6.17 0.35 2.6e-9 Schizophrenia; CESC trans rs3942852 0.568 rs10769312 chr11:48094769 C/T cg15704280 chr7:45808275 SEPT13 0.72 9.16 0.49 1.49e-17 Acute lymphoblastic leukemia (childhood); CESC cis rs787274 0.543 rs10116897 chr9:115633479 C/T cg13803584 chr9:115635662 SNX30 -0.68 -6.63 -0.38 1.86e-10 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs10489896 0.541 rs12760253 chr1:234577514 G/C cg23817893 chr11:86085932 CCDC81 -0.46 -6.41 -0.37 6.57e-10 Cognitive test performance; CESC cis rs12545109 0.800 rs2576602 chr8:57394495 C/T cg09654669 chr8:57350985 NA -0.57 -7.21 -0.41 5.73e-12 Obesity-related traits; CESC cis rs6582630 0.555 rs10748382 chr12:38504529 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.8 0.34 1.91e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs116095464 0.764 rs10069197 chr5:230822 G/C cg00938859 chr5:1591904 SDHAP3 0.61 6.74 0.38 9.82e-11 Breast cancer; CESC cis rs1559088 1.000 rs8106453 chr19:33557412 C/T cg27124370 chr19:33622961 WDR88 0.42 5.33 0.31 2.07e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12748961 0.557 rs823127 chr1:205713139 G/A cg23034840 chr1:205782522 SLC41A1 0.54 6.15 0.35 2.84e-9 White blood cell types; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22018784 chr9:98079448 FANCC -0.47 -6.44 -0.37 5.71e-10 Gambling; CESC cis rs904092 0.786 rs2646011 chr4:100161381 A/G cg12011299 chr4:100065546 ADH4 0.54 6.09 0.35 3.89e-9 Alcohol dependence; CESC cis rs9658691 0.736 rs9658727 chr10:90761865 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.64 -5.06 -0.3 7.71e-7 Mosquito bite size; CESC cis rs7208859 0.673 rs11656845 chr17:29206164 G/T cg19761014 chr17:28927070 LRRC37B2 0.7 5.48 0.32 9.75e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg25072359 chr17:41440525 NA 0.45 6.07 0.35 4.5e-9 Menopause (age at onset); CESC cis rs7107174 1.000 rs4134379 chr11:77992588 A/G cg02023728 chr11:77925099 USP35 0.37 5.43 0.32 1.27e-7 Testicular germ cell tumor; CESC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.76 9.27 0.49 6.91e-18 Height; CESC cis rs4595586 0.545 rs1349257 chr12:39397139 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.27 0.41 4.12e-12 Morning vs. evening chronotype; CESC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg02038168 chr22:39784481 NA -0.71 -8.28 -0.45 6.14e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg06221963 chr1:154839813 KCNN3 -0.5 -7.43 -0.42 1.54e-12 Prostate cancer; CESC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg11644478 chr21:40555479 PSMG1 -0.94 -14.21 -0.66 1.91e-34 Cognitive function; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08925066 chr14:39572669 SEC23A 0.49 6.67 0.38 1.46e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1707322 0.752 rs8179402 chr1:46142466 C/A cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs763121 0.889 rs9610971 chr22:38910810 C/T cg06544989 chr22:39130855 UNC84B 0.44 7.25 0.41 4.66e-12 Menopause (age at onset); CESC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg21724239 chr8:58056113 NA 0.58 5.91 0.34 1.02e-8 Developmental language disorder (linguistic errors); CESC cis rs763014 0.898 rs62030902 chr16:638264 C/G cg00908189 chr16:619842 PIGQ 0.64 8.59 0.47 7.59e-16 Height; CESC cis rs644799 0.862 rs1150361 chr11:95633805 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.46 5.61 0.33 5.06e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9388451 0.591 rs1268792 chr6:126042124 G/A cg05901451 chr6:126070800 HEY2 0.54 7.63 0.42 4.19e-13 Brugada syndrome; CESC cis rs7116495 0.609 rs10898812 chr11:71698801 G/A cg10381502 chr11:71823885 C11orf51 -1.19 -7.81 -0.43 1.32e-13 Severe influenza A (H1N1) infection; CESC cis rs27434 0.605 rs1230366 chr5:96195280 A/G cg16492584 chr5:96139282 ERAP1 -0.53 -5.94 -0.34 8.99e-9 Ankylosing spondylitis; CESC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.87 13.16 0.63 8.66e-31 Prudent dietary pattern; CESC cis rs13343954 0.518 rs7252086 chr19:33534929 T/C cg17764715 chr19:33622953 WDR88 0.55 7.29 0.41 3.62e-12 Colorectal cancer; CESC cis rs80130819 0.688 rs2468945 chr12:48652414 G/A cg05342945 chr12:48394962 COL2A1 -0.49 -5.33 -0.31 2.14e-7 Prostate cancer; CESC cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7945705 0.967 rs34842234 chr11:8891894 G/A cg12365402 chr11:9010492 NRIP3 0.36 5.61 0.33 5.01e-8 Hemoglobin concentration; CESC cis rs7937682 0.889 rs7948236 chr11:111499933 C/A cg09085632 chr11:111637200 PPP2R1B -0.99 -15.84 -0.7 3.24e-40 Primary sclerosing cholangitis; CESC cis rs4835473 0.614 rs4487293 chr4:144915033 C/G cg25736465 chr4:144833511 NA 0.43 6.38 0.36 8.02e-10 Immature fraction of reticulocytes; CESC cis rs763014 0.898 rs2017567 chr16:637212 T/C cg09781414 chr16:715207 WDR90 -0.33 -5.03 -0.3 9.06e-7 Height; CESC cis rs7659604 0.540 rs4075065 chr4:122683906 A/G cg19671926 chr4:122722719 EXOSC9 0.58 7.25 0.41 4.44e-12 Type 2 diabetes; CESC cis rs6547741 0.935 rs4260197 chr2:27794150 C/G cg21248554 chr2:27665150 KRTCAP3 -0.26 -5.44 -0.32 1.23e-7 Oral cavity cancer; CESC cis rs858239 0.669 rs12539467 chr7:23115859 A/G cg23682824 chr7:23144976 KLHL7 0.5 6.43 0.37 5.85e-10 Cerebrospinal fluid biomarker levels; CESC cis rs258892 0.895 rs13164198 chr5:72051641 G/T cg21869765 chr5:72125136 TNPO1 0.4 5.36 0.31 1.83e-7 Small cell lung carcinoma; CESC cis rs2243480 1.000 rs10950032 chr7:65738591 C/A cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs4930103 0.602 rs170101 chr11:2008936 C/T cg23202291 chr11:1979235 NA 0.36 5.06 0.3 7.84e-7 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg23978390 chr7:1156363 C7orf50 0.58 8.45 0.46 1.94e-15 Longevity;Endometriosis; CESC cis rs9633740 1.000 rs6586028 chr10:82253984 C/T cg00277334 chr10:82204260 NA -0.57 -5.85 -0.34 1.42e-8 Post bronchodilator FEV1; CESC cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.75 0.38 9.2e-11 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs10782582 0.593 rs17848068 chr1:76190216 G/A cg10523679 chr1:76189770 ACADM -0.45 -5.35 -0.31 1.87e-7 Daytime sleep phenotypes; CESC cis rs899997 0.862 rs8032552 chr15:78971136 T/C cg04896959 chr15:78267971 NA -0.36 -5.16 -0.3 4.94e-7 Coronary artery disease or large artery stroke; CESC cis rs11583043 0.874 rs6577219 chr1:101415707 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.54 6.01 0.35 6.1e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs8180040 0.900 rs4858894 chr3:47484953 C/G cg27129171 chr3:47204927 SETD2 0.62 9.25 0.49 7.87e-18 Colorectal cancer; CESC cis rs873946 0.689 rs2803993 chr10:134550606 T/C cg27286337 chr10:134555280 INPP5A 0.72 9.02 0.48 4e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs16857609 0.550 rs1351163 chr2:218267992 A/G cg15335768 chr2:218268053 DIRC3 -0.41 -5.76 -0.33 2.28e-8 Breast cancer;Breast cancer (estrogen-receptor negative); CESC cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg10523679 chr1:76189770 ACADM 0.69 7.93 0.44 6.25e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7809950 1.000 rs2253146 chr7:107200319 A/G cg23024343 chr7:107201750 COG5 -0.41 -5.72 -0.33 2.85e-8 Coronary artery disease; CESC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg03676636 chr4:99064102 C4orf37 0.37 5.37 0.31 1.75e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3126085 0.935 rs7534716 chr1:152198654 A/G cg03465714 chr1:152285911 FLG -0.43 -5.24 -0.31 3.23e-7 Atopic dermatitis; CESC cis rs12824058 0.678 rs11614163 chr12:130814621 C/G cg23887609 chr12:130822674 PIWIL1 0.45 5.54 0.32 7.17e-8 Menopause (age at onset); CESC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg02725872 chr8:58115012 NA -0.45 -6.84 -0.39 5.31e-11 Developmental language disorder (linguistic errors); CESC cis rs7608623 0.644 rs2339940 chr2:24251787 G/T cg20701182 chr2:24300061 SF3B14 -0.41 -5.41 -0.32 1.44e-7 Obesity-related traits; CESC cis rs5753618 0.539 rs8135344 chr22:31671932 G/T cg13145458 chr22:31556086 RNF185 0.48 5.4 0.31 1.51e-7 Colorectal cancer; CESC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg22508957 chr16:3507546 NAT15 0.56 9.21 0.49 1.01e-17 Tuberculosis; CESC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg13944838 chr5:179740914 GFPT2 -0.62 -8.31 -0.45 5.16e-15 Height; CESC cis rs11122272 0.705 rs2486742 chr1:231507254 G/A cg06096015 chr1:231504339 EGLN1 0.39 5.68 0.33 3.49e-8 Hemoglobin concentration; CESC cis rs11190604 1.000 rs2495732 chr10:102357780 T/C cg07080220 chr10:102295463 HIF1AN 0.61 5.47 0.32 1.03e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs6500395 1.000 rs11076573 chr16:48632758 A/G cg04672837 chr16:48644449 N4BP1 0.53 6.72 0.38 1.08e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs8016982 0.674 rs1957549 chr14:81706179 G/A cg01989461 chr14:81687754 GTF2A1 0.74 11.64 0.58 1.44e-25 Schizophrenia; CESC cis rs2404602 0.716 rs12438077 chr15:76863601 T/C cg26408565 chr15:76604113 ETFA -0.4 -5.72 -0.33 2.92e-8 Blood metabolite levels; CESC cis rs34779708 0.931 rs67976880 chr10:35372261 G/C cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs4722166 0.630 rs10950916 chr7:22799667 C/T cg26061582 chr7:22766209 IL6 0.51 5.37 0.31 1.71e-7 Lung cancer; CESC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.77 0.65 6.55e-33 Prudent dietary pattern; CESC cis rs12476592 0.571 rs10865341 chr2:63824050 A/T cg17519650 chr2:63277830 OTX1 -0.46 -5.14 -0.3 5.28e-7 Childhood ear infection; CESC cis rs793571 0.714 rs972801 chr15:58921198 C/T cg05156742 chr15:59063176 FAM63B -0.64 -8.58 -0.47 7.95e-16 Schizophrenia; CESC cis rs9291683 0.595 rs3733585 chr4:10036339 A/G cg02734326 chr4:10020555 SLC2A9 0.49 6.84 0.39 5.6e-11 Bone mineral density; CESC cis rs1707322 0.721 rs11211157 chr1:46132844 T/C cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4889855 0.556 rs4297763 chr17:78533626 G/C cg16591659 chr17:78472290 NA 0.34 5.86 0.34 1.35e-8 Fractional excretion of uric acid; CESC cis rs10463316 0.962 rs61647401 chr5:150743076 T/C cg03212797 chr5:150827313 SLC36A1 -0.44 -5.19 -0.3 4.25e-7 Metabolite levels (Pyroglutamine); CESC cis rs8067354 0.645 rs11079389 chr17:57887952 G/A cg02344993 chr17:57696989 CLTC 0.56 6.04 0.35 5.31e-9 Hemoglobin concentration; CESC cis rs9814567 0.712 rs9838467 chr3:134332222 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.1 -0.3 6.38e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg17724175 chr1:150552817 MCL1 0.41 6.29 0.36 1.29e-9 Melanoma; CESC cis rs2637266 0.549 rs11516640 chr10:78414532 A/G cg18941641 chr10:78392320 NA -0.32 -5.25 -0.31 3.12e-7 Pulmonary function; CESC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg17971929 chr21:40555470 PSMG1 -0.55 -7.16 -0.4 8.14e-12 Menarche (age at onset); CESC cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg15017067 chr4:17643749 FAM184B 0.37 5.36 0.31 1.79e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6964587 1.000 rs7455444 chr7:91639313 C/T cg17063962 chr7:91808500 NA 0.57 7.92 0.44 6.39e-14 Breast cancer; CESC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg26850624 chr5:429559 AHRR -0.48 -6.63 -0.38 1.85e-10 Cystic fibrosis severity; CESC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg22520471 chr17:61851767 DDX42;CCDC47 -0.58 -7.24 -0.41 4.99e-12 Height; CESC cis rs6582630 0.554 rs8189625 chr12:38401177 C/T cg26384229 chr12:38710491 ALG10B -0.46 -6.19 -0.36 2.32e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs11112613 0.713 rs11112587 chr12:105941285 G/A cg03607813 chr12:105948248 NA 0.64 7.77 0.43 1.69e-13 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs72781680 0.752 rs72796138 chr2:23926233 C/T cg08917208 chr2:24149416 ATAD2B 1.1 10.19 0.53 8.84e-21 Lymphocyte counts; CESC cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg12927641 chr6:109611667 NA -0.43 -6.63 -0.38 1.91e-10 Reticulocyte fraction of red cells; CESC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 12.81 0.62 1.48e-29 Alzheimer's disease; CESC trans rs7615952 0.576 rs2276727 chr3:125826243 C/T cg07211511 chr3:129823064 LOC729375 -0.56 -6.33 -0.36 1.05e-9 Blood pressure (smoking interaction); CESC cis rs910316 0.763 rs175014 chr14:75456927 A/G cg11812906 chr14:75593930 NEK9 -0.8 -12.37 -0.6 4.8e-28 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00634145 chr1:155108588 RAG1AP1 -0.51 -6.17 -0.35 2.55e-9 Ulcerative colitis; CESC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg22823121 chr1:150693482 HORMAD1 0.46 6.33 0.36 1.07e-9 Melanoma; CESC trans rs561341 0.714 rs474455 chr17:30312465 A/T cg20587970 chr11:113659929 NA -1.11 -14.12 -0.66 3.82e-34 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs734999 0.545 rs10910105 chr1:2538209 G/A cg20673091 chr1:2541236 MMEL1 0.46 7.59 0.42 5.5e-13 Ulcerative colitis; CESC cis rs17376456 0.825 rs28534784 chr5:93063332 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.3 0.31 2.48e-7 Diabetic retinopathy; CESC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -7.91 -0.44 7.01e-14 Personality dimensions; CESC cis rs6456156 0.792 rs4710179 chr6:167513692 G/T cg07741184 chr6:167504864 NA 0.38 6.94 0.39 2.95e-11 Primary biliary cholangitis; CESC cis rs2404602 0.692 rs3816266 chr15:76993835 T/G cg26408565 chr15:76604113 ETFA -0.39 -5.58 -0.32 6.05e-8 Blood metabolite levels; CESC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg26516362 chr5:178986906 RUFY1 0.48 7.76 0.43 1.88e-13 Lung cancer; CESC cis rs11098499 0.954 rs35091806 chr4:120325529 G/A cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs12620999 0.838 rs7589198 chr2:237967615 C/T cg23555395 chr2:238036564 NA 0.46 6.3 0.36 1.22e-9 Systemic lupus erythematosus; CESC cis rs4450798 0.793 rs28581168 chr3:13740488 A/C cg05589046 chr3:13742034 LOC285375 0.37 5.49 0.32 9.59e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7726839 0.540 rs55929359 chr5:595956 C/G cg16447950 chr5:562315 NA -0.59 -5.95 -0.34 8.59e-9 Obesity-related traits; CESC cis rs10899021 0.920 rs76121309 chr11:74343921 A/T cg25880958 chr11:74394337 NA -0.77 -7.0 -0.39 2.11e-11 Response to metformin (IC50); CESC cis rs7107174 1.000 rs10899469 chr11:78018313 T/C cg02023728 chr11:77925099 USP35 0.48 6.32 0.36 1.09e-9 Testicular germ cell tumor; CESC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg26338869 chr17:61819248 STRADA 0.69 9.24 0.49 8.34e-18 Prudent dietary pattern; CESC cis rs6570726 1.000 rs386678 chr6:145869010 A/G cg23711669 chr6:146136114 FBXO30 0.71 10.38 0.54 2.11e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg15445000 chr17:37608096 MED1 -0.4 -6.52 -0.37 3.49e-10 Glomerular filtration rate (creatinine); CESC cis rs4820539 1.000 rs916584 chr22:23469433 A/G cg14186256 chr22:23484241 RTDR1 0.81 14.26 0.66 1.27e-34 Bone mineral density; CESC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg06221963 chr1:154839813 KCNN3 -0.68 -11.73 -0.58 7.29e-26 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03837292 chr11:67049397 ADRBK1 -0.59 -6.54 -0.37 3.24e-10 Gut microbiome composition (summer); CESC cis rs5758659 1.000 rs5751255 chr22:42648408 C/T cg05082376 chr22:42548792 NA -0.39 -5.75 -0.33 2.5e-8 Cognitive function; CESC cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg24209194 chr3:40518798 ZNF619 -0.49 -6.17 -0.35 2.58e-9 Renal cell carcinoma; CESC cis rs2228479 0.867 rs62052168 chr16:89947203 G/A cg06558623 chr16:89946397 TCF25 1.15 9.14 0.49 1.65e-17 Skin colour saturation; CESC trans rs9467711 0.606 rs34622023 chr6:26362119 A/T cg06606381 chr12:133084897 FBRSL1 -0.76 -7.08 -0.4 1.28e-11 Autism spectrum disorder or schizophrenia; CESC cis rs4594175 0.926 rs72688713 chr14:51598375 C/T cg23942311 chr14:51606299 NA 0.37 5.4 0.31 1.48e-7 Cancer; CESC cis rs11191270 0.554 rs77616533 chr10:104055983 A/G cg15320455 chr10:103880129 LDB1 0.61 5.82 0.34 1.65e-8 Intelligence (multi-trait analysis); CESC cis rs10465746 0.935 rs12133778 chr1:84367626 A/G cg10977910 chr1:84465055 TTLL7 0.48 6.34 0.36 9.89e-10 Obesity-related traits; CESC cis rs7666738 0.716 rs9994641 chr4:99101605 C/T cg24818145 chr4:99064322 C4orf37 0.4 5.03 0.3 9.06e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 1.000 rs386548 chr6:167385533 A/T cg07741184 chr6:167504864 NA -0.32 -5.78 -0.33 2.1e-8 Crohn's disease; CESC cis rs950776 0.518 rs4243083 chr15:78833830 C/G cg06917634 chr15:78832804 PSMA4 -0.79 -12.1 -0.6 4.1e-27 Sudden cardiac arrest; CESC cis rs7520050 0.807 rs28844317 chr1:46209207 T/C cg03146154 chr1:46216737 IPP 0.51 6.79 0.39 7.23e-11 Red blood cell count;Reticulocyte count; CESC cis rs6831352 0.918 rs3919370 chr4:100064326 A/T cg12011299 chr4:100065546 ADH4 -0.58 -6.31 -0.36 1.14e-9 Alcohol dependence; CESC cis rs9487051 0.738 rs171272 chr6:109530094 T/C cg01475377 chr6:109611718 NA -0.45 -6.83 -0.39 5.94e-11 Reticulocyte fraction of red cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03697509 chr11:72466028 STARD10 0.48 6.62 0.38 2.04e-10 Fibrinogen levels; CESC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.62 8.66 0.47 4.87e-16 Intelligence (multi-trait analysis); CESC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg18758796 chr5:131593413 PDLIM4 -0.42 -5.74 -0.33 2.56e-8 Breast cancer; CESC cis rs4803468 1.000 rs284652 chr19:41928652 C/T cg14132834 chr19:41945861 ATP5SL -0.66 -8.18 -0.45 1.22e-14 Height; CESC cis rs60843830 0.928 rs62114494 chr2:211317 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.73 9.05 0.49 3.23e-17 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1707322 1.000 rs11211223 chr1:46380605 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.51e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2243480 1.000 rs958550 chr7:65635679 C/T cg13147721 chr7:65941812 NA 0.95 8.89 0.48 9.63e-17 Diabetic kidney disease; CESC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg17724175 chr1:150552817 MCL1 0.38 5.9 0.34 1.11e-8 Melanoma; CESC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 5.02e-9 Prudent dietary pattern; CESC cis rs7216064 1.000 rs12600941 chr17:65918807 A/G cg12091567 chr17:66097778 LOC651250 -0.8 -8.05 -0.44 2.9e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6460942 0.630 rs1866650 chr7:12396897 C/T cg06484146 chr7:12443880 VWDE -0.67 -7.12 -0.4 9.88e-12 Coronary artery disease; CESC cis rs9486715 0.867 rs9486444 chr6:96963619 A/G cg06623918 chr6:96969491 KIAA0776 0.92 14.17 0.66 2.59e-34 Headache; CESC cis rs7072216 0.727 rs7913541 chr10:100172479 A/G cg26618903 chr10:100175079 PYROXD2 -0.38 -5.85 -0.34 1.41e-8 Metabolite levels; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg06925236 chr11:68039653 C11orf24 0.48 6.17 0.35 2.56e-9 Tetralogy of Fallot; CESC trans rs1814175 0.645 rs1851844 chr11:50021773 T/C cg03929089 chr4:120376271 NA -0.91 -14.8 -0.67 1.58e-36 Height; CESC cis rs1670533 1.000 rs604597 chr4:1094151 G/A cg04106633 chr4:1044584 NA -0.4 -5.16 -0.3 4.94e-7 Recombination rate (females); CESC cis rs6963495 0.818 rs73190184 chr7:105163736 C/T cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs12474201 0.775 rs7584870 chr2:46973400 A/T cg06386533 chr2:46925753 SOCS5 0.74 10.33 0.54 3.15e-21 Height; CESC cis rs7618501 1.000 rs34614773 chr3:49753003 T/G cg24308560 chr3:49941425 MST1R 0.5 6.94 0.39 3.09e-11 Intelligence (multi-trait analysis); CESC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg08109568 chr15:31115862 NA 0.71 9.6 0.51 6.47e-19 Huntington's disease progression; CESC cis rs68170813 0.523 rs12532447 chr7:106940476 C/T cg02696742 chr7:106810147 HBP1 -0.55 -5.17 -0.3 4.54e-7 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14990712 chr19:4055085 ZBTB7A 0.46 6.1 0.35 3.74e-9 Fibrinogen levels; CESC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg02569458 chr12:86230093 RASSF9 0.48 7.19 0.4 6.74e-12 Major depressive disorder; CESC cis rs7923609 1.000 rs10761742 chr10:65085048 A/G cg01631684 chr10:65280961 REEP3 -0.44 -5.56 -0.32 6.51e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg21782813 chr7:2030301 MAD1L1 0.51 7.37 0.41 2.14e-12 Bipolar disorder and schizophrenia; CESC cis rs7551222 0.752 rs10900593 chr1:204470096 G/T cg20240347 chr1:204465584 NA -0.27 -5.52 -0.32 7.89e-8 Schizophrenia; CESC cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg17427002 chr7:12443146 VWDE -0.51 -5.04 -0.3 8.48e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10137990 chr8:145137203 GPAA1 0.58 6.79 0.38 7.37e-11 Gut microbiome composition (summer); CESC cis rs939658 0.805 rs2177056 chr15:79441489 T/C cg17916960 chr15:79447300 NA -0.35 -5.98 -0.34 7.25e-9 Refractive error; CESC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -12.93 -0.62 5.44e-30 Developmental language disorder (linguistic errors); CESC cis rs2652834 0.904 rs2729827 chr15:63360564 C/T cg05507819 chr15:63340323 TPM1 0.58 6.03 0.35 5.41e-9 HDL cholesterol; CESC cis rs9467711 0.606 rs9358930 chr6:26357011 C/T cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.52e-7 Autism spectrum disorder or schizophrenia; CESC trans rs17685 0.712 rs1859794 chr7:75821544 G/A cg19862616 chr7:65841803 NCRNA00174 0.81 11.3 0.57 1.92e-24 Coffee consumption;Coffee consumption (cups per day); CESC cis rs12136530 0.538 rs115773162 chr1:19763168 G/T cg01832549 chr1:19774989 CAPZB -0.46 -6.55 -0.37 2.9e-10 Lead levels in blood; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01908177 chr3:113005203 BOC 0.44 6.29 0.36 1.28e-9 Fibrinogen levels; CESC cis rs2439831 0.850 rs28891769 chr15:44072860 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.97 0.44 4.59e-14 Lung cancer in ever smokers; CESC cis rs7607369 0.637 rs17462630 chr2:219286541 C/G cg02176678 chr2:219576539 TTLL4 -0.43 -6.84 -0.39 5.37e-11 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs939658 0.805 rs11635757 chr15:79432737 T/C cg17916960 chr15:79447300 NA -0.36 -5.98 -0.34 7.3e-9 Refractive error; CESC cis rs858239 0.600 rs7788821 chr7:23133645 A/T cg23682824 chr7:23144976 KLHL7 0.54 7.34 0.41 2.63e-12 Cerebrospinal fluid biomarker levels; CESC cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg20701182 chr2:24300061 SF3B14 0.94 10.39 0.54 2.01e-21 Lymphocyte counts; CESC cis rs1003719 0.788 rs2835605 chr21:38490734 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs11098499 0.955 rs1511018 chr4:120161580 G/T cg24375607 chr4:120327624 NA 0.43 5.23 0.31 3.41e-7 Corneal astigmatism; CESC cis rs2832191 0.632 rs1984011 chr21:30337831 T/A cg24692254 chr21:30365293 RNF160 -0.96 -17.02 -0.72 2.03e-44 Dental caries; CESC cis rs7618915 0.501 rs55678971 chr3:52717229 T/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.4 7.05 0.4 1.54e-11 Bipolar disorder; CESC cis rs523522 0.962 rs10849753 chr12:120910813 C/T cg27279351 chr12:120934652 DYNLL1 0.68 8.74 0.47 2.65e-16 High light scatter reticulocyte count; CESC cis rs7561273 0.609 rs10200844 chr2:24293363 A/C cg20701182 chr2:24300061 SF3B14 0.45 6.03 0.35 5.41e-9 Quantitative traits; CESC cis rs2425143 0.908 rs6060632 chr20:34422601 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.4 0.31 1.52e-7 Blood protein levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19371097 chr1:17735001 RCC2 -0.49 -6.35 -0.36 9.32e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs3780486 0.846 rs6476402 chr9:33148552 G/A cg20290983 chr6:43655470 MRPS18A 0.95 16.66 0.72 3.99e-43 IgG glycosylation; CESC cis rs2180341 0.782 rs4897214 chr6:127723625 G/T cg27446573 chr6:127587934 RNF146 0.8 11.46 0.58 5.73e-25 Breast cancer; CESC cis rs11048434 0.687 rs12814670 chr12:9060025 C/T cg04155231 chr12:9217510 LOC144571 0.33 5.47 0.32 1.06e-7 Sjögren's syndrome; CESC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg12516959 chr21:47718080 NA 0.45 6.18 0.35 2.4e-9 Testicular germ cell tumor; CESC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg23172400 chr8:95962367 TP53INP1 -0.48 -10.11 -0.53 1.51e-20 Type 2 diabetes; CESC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg23281280 chr6:28129359 ZNF389 0.43 6.41 0.37 6.55e-10 Cardiac Troponin-T levels; CESC cis rs7044106 0.791 rs4837792 chr9:123483559 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.28 0.53 4.36e-21 Hip circumference adjusted for BMI; CESC cis rs2832191 0.692 rs2776240 chr21:30310639 C/T cg24692254 chr21:30365293 RNF160 0.95 17.09 0.72 1.15e-44 Dental caries; CESC cis rs6142102 0.625 rs1883705 chr20:32552878 C/T cg08999081 chr20:33150536 PIGU 0.34 5.1 0.3 6.63e-7 Skin pigmentation; CESC cis rs34779708 0.931 rs12771399 chr10:35452377 C/T cg03585969 chr10:35415529 CREM 0.78 10.33 0.54 2.95e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg27170947 chr2:26402098 FAM59B -0.6 -7.25 -0.41 4.7e-12 Gut microbiome composition (summer); CESC cis rs798554 0.591 rs757791 chr7:2867296 A/G cg13628971 chr7:2884303 GNA12 0.42 5.54 0.32 7.14e-8 Height; CESC cis rs1670533 1.000 rs3816474 chr4:1050653 G/A cg27284194 chr4:1044797 NA 0.49 5.23 0.31 3.4e-7 Recombination rate (females); CESC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.526 rs11682621 chr2:27749669 G/A cg21248554 chr2:27665150 KRTCAP3 -0.33 -6.63 -0.38 1.85e-10 Total body bone mineral density; CESC cis rs16866061 0.890 rs72972401 chr2:225404668 T/C cg12698349 chr2:225449008 CUL3 0.75 11.48 0.58 5.14e-25 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs9300255 0.568 rs3018098 chr12:123654812 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.19e-16 Neutrophil percentage of white cells; CESC cis rs2637266 0.935 rs4353214 chr10:78393149 C/T cg18941641 chr10:78392320 NA -0.43 -8.28 -0.45 6.19e-15 Pulmonary function; CESC cis rs1215050 0.740 rs783963 chr4:98989070 A/G cg17366294 chr4:99064904 C4orf37 0.44 5.99 0.35 6.73e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg27535305 chr1:53392650 SCP2 -0.32 -5.08 -0.3 7.25e-7 Monocyte count; CESC trans rs875971 1.000 rs778722 chr7:65844828 T/C cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.69e-9 Aortic root size; CESC cis rs17407555 0.862 rs11729685 chr4:10276787 G/T cg11266682 chr4:10021025 SLC2A9 -0.41 -5.26 -0.31 2.92e-7 Schizophrenia (age at onset); CESC cis rs5769765 1.000 rs8184990 chr22:50273174 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.45 5.28 0.31 2.7e-7 Schizophrenia; CESC cis rs9790314 0.875 rs336580 chr3:161082982 A/T cg03342759 chr3:160939853 NMD3 -0.41 -5.4 -0.31 1.5e-7 Morning vs. evening chronotype; CESC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.18 0.53 9.01e-21 Mean platelet volume; CESC cis rs3820068 0.705 rs72643694 chr1:15860185 C/T cg17385448 chr1:15911702 AGMAT 0.36 5.62 0.33 4.86e-8 Systolic blood pressure; CESC trans rs367943 1.000 rs348961 chr5:112819944 A/C cg08495027 chr22:31364830 MORC2;TUG1 -0.62 -6.05 -0.35 5.01e-9 Type 2 diabetes; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg03067462 chr11:2422131 TSSC4 0.48 6.42 0.37 6.34e-10 Myopia (pathological); CESC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg00149659 chr3:10157352 C3orf10 -0.7 -8.16 -0.45 1.37e-14 Alzheimer's disease; CESC cis rs9522267 0.535 rs9522305 chr13:112237550 A/G cg10483660 chr13:112241077 NA -0.32 -5.69 -0.33 3.29e-8 Hepatitis; CESC cis rs9868809 0.772 rs9809222 chr3:48714411 C/T cg07636037 chr3:49044803 WDR6 -0.64 -5.65 -0.33 4.04e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs1878931 0.696 rs35175748 chr16:3445427 C/G cg22508957 chr16:3507546 NAT15 -0.43 -6.4 -0.37 7.11e-10 Body mass index (adult); CESC cis rs763121 0.962 rs138711 chr22:39139913 C/T cg06544989 chr22:39130855 UNC84B 0.4 6.69 0.38 1.3100000000000001e-10 Menopause (age at onset); CESC cis rs1048238 0.506 rs848209 chr1:16256007 T/C cg21385522 chr1:16154831 NA -0.43 -5.38 -0.31 1.63e-7 Systolic blood pressure; CESC cis rs3126085 0.935 rs3126043 chr1:152256030 C/G cg03465714 chr1:152285911 FLG -0.44 -5.62 -0.33 4.84e-8 Atopic dermatitis; CESC cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg23583168 chr7:148888333 NA -0.77 -11.26 -0.57 2.68e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg17372223 chr3:52568218 NT5DC2 0.41 6.34 0.36 9.92e-10 Intelligence (multi-trait analysis); CESC cis rs4889855 0.530 rs4889865 chr17:78568447 A/T cg16591659 chr17:78472290 NA 0.35 5.73 0.33 2.77e-8 Fractional excretion of uric acid; CESC trans rs11098499 0.691 rs9996494 chr4:120238880 C/A cg25214090 chr10:38739885 LOC399744 0.59 8.08 0.44 2.33e-14 Corneal astigmatism; CESC cis rs897984 0.568 rs4889653 chr16:30895713 C/T cg02466173 chr16:30829666 NA 0.43 6.27 0.36 1.43e-9 Dementia with Lewy bodies; CESC trans rs55704346 0.566 rs12509843 chr4:25385456 G/A cg01822600 chr1:245751692 KIF26B 0.43 6.27 0.36 1.44e-9 Tonsillectomy; CESC trans rs1728785 1.000 rs698728 chr16:68625253 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.72 0.43 2.35e-13 Ulcerative colitis; CESC cis rs11822910 0.737 rs2584858 chr11:57207077 C/T cg00522883 chr11:57194120 SLC43A3 0.55 7.04 0.4 1.68e-11 Platelet distribution width; CESC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg01171360 chr6:293285 DUSP22 -0.67 -8.79 -0.48 1.96e-16 Menopause (age at onset); CESC cis rs595982 0.527 rs73061659 chr19:49373556 G/A cg15549821 chr19:49342101 PLEKHA4 -0.65 -6.96 -0.39 2.63e-11 Red cell distribution width; CESC cis rs1348850 0.872 rs2084233 chr2:178331206 G/A cg23306229 chr2:178417860 TTC30B 0.66 8.16 0.45 1.32e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23379540 chr12:51611600 POU6F1 0.6 6.25 0.36 1.59e-9 Gut microbiome composition (summer); CESC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg21984481 chr17:79567631 NPLOC4 0.35 5.45 0.32 1.14e-7 Eye color traits; CESC trans rs4513299 1.000 rs4849326 chr2:115078288 T/A cg26275355 chr4:12252318 NA -0.36 -6.2 -0.36 2.2e-9 Inflammatory biomarkers; CESC cis rs7208859 0.623 rs7220999 chr17:29149298 C/T cg14008862 chr17:28927542 LRRC37B2 0.66 5.21 0.3 3.84e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg23048001 chr7:2026167 MAD1L1 0.41 5.24 0.31 3.36e-7 Bipolar disorder and schizophrenia; CESC cis rs6912958 0.712 rs2814712 chr6:88396322 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.5 6.49 0.37 4.31e-10 Monocyte percentage of white cells; CESC cis rs9309473 1.000 rs60844734 chr2:73623205 T/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.49 -0.37 4.28e-10 Metabolite levels; CESC cis rs13223928 0.572 rs16870744 chr7:3135781 G/A cg19214707 chr7:3157722 NA -0.39 -5.37 -0.31 1.74e-7 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3092073 0.624 rs11696623 chr20:44580380 C/T cg00125455 chr20:44574271 PCIF1 0.38 6.0 0.35 6.32e-9 Intelligence (multi-trait analysis); CESC cis rs7107174 1.000 rs2512541 chr11:77981747 A/T cg02023728 chr11:77925099 USP35 0.48 6.86 0.39 4.75e-11 Testicular germ cell tumor; CESC cis rs11122272 0.766 rs2790871 chr1:231543555 G/C cg06096015 chr1:231504339 EGLN1 0.41 5.71 0.33 3e-8 Hemoglobin concentration; CESC cis rs477692 0.673 rs511361 chr10:131365052 C/T cg24747557 chr10:131355152 MGMT -0.39 -5.25 -0.31 3.14e-7 Response to temozolomide; CESC cis rs9910055 0.530 rs11656758 chr17:42301541 A/G cg19774624 chr17:42201019 HDAC5 -0.6 -8.66 -0.47 4.59e-16 Total body bone mineral density; CESC cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.95 0.48 6.42e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg18876405 chr7:65276391 NA 0.51 5.96 0.34 8.21e-9 Aortic root size; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg06324094 chr1:153950482 JTB 0.52 6.18 0.35 2.46e-9 Psoriatic arthritis; CESC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg08736216 chr1:53307985 ZYG11A -0.41 -6.77 -0.38 8.37e-11 Monocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23806609 chr7:66369525 NA 0.52 7.42 0.41 1.58e-12 Fibrinogen levels; CESC cis rs11718455 0.883 rs2372579 chr3:44034003 A/T cg08738300 chr3:44038990 NA 0.48 6.41 0.37 6.74e-10 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24073613 chr1:210424721 NA -0.53 -7.19 -0.4 6.73e-12 Fibrinogen levels; CESC cis rs9902453 0.904 rs9905638 chr17:28261022 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 9.16 0.49 1.49e-17 Coffee consumption (cups per day); CESC cis rs4971059 0.617 rs12127609 chr1:155133491 G/C cg22049894 chr1:155113146 DPM3 0.48 6.07 0.35 4.32e-9 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.11.41625527F chr11:41668953 NA -0.62 -6.62 -0.38 1.95e-10 Gut microbiome composition (summer); CESC trans rs61931739 0.500 rs11524949 chr12:34435551 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.32 0.54 3.19e-21 Morning vs. evening chronotype; CESC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg13206674 chr6:150067644 NUP43 0.42 5.83 0.34 1.65e-8 Lung cancer; CESC cis rs9300255 0.602 rs1617434 chr12:123649486 A/G cg00376283 chr12:123451042 ABCB9 0.58 6.51 0.37 3.75e-10 Neutrophil percentage of white cells; CESC cis rs4835473 0.932 rs62339580 chr4:144706243 A/G cg25736465 chr4:144833511 NA -0.33 -5.43 -0.32 1.28e-7 Immature fraction of reticulocytes; CESC cis rs7395581 1.000 rs830085 chr11:47251199 G/A cg25783544 chr11:47291846 MADD -0.57 -7.61 -0.42 4.96e-13 HDL cholesterol; CESC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg12311346 chr5:56204834 C5orf35 0.48 5.77 0.33 2.17e-8 Coronary artery disease; CESC cis rs6061231 0.631 rs2427318 chr20:60975727 G/T cg22541963 chr20:60982533 CABLES2 0.41 5.27 0.31 2.79e-7 Colorectal cancer; CESC cis rs9900062 1.000 rs11871616 chr17:62737602 C/T cg02598441 chr17:62777298 LOC146880 -0.67 -8.07 -0.44 2.53e-14 QT interval; CESC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC cis rs1153858 0.621 rs2687512 chr15:45581495 T/C cg21132104 chr15:45694354 SPATA5L1 -0.77 -9.37 -0.5 3.33e-18 Homoarginine levels; CESC cis rs2797160 1.000 rs1739348 chr6:126014573 T/C cg05901451 chr6:126070800 HEY2 0.46 6.55 0.37 2.89e-10 Endometrial cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00399650 chr7:141402322 KIAA1147 0.52 7.08 0.4 1.31e-11 Gut microbiota (bacterial taxa); CESC cis rs2011503 0.882 rs10401714 chr19:19363630 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.54 5.73 0.33 2.76e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17472072 chr3:33759422 CLASP2 0.61 7.09 0.4 1.19e-11 Gut microbiome composition (summer); CESC cis rs901683 1.000 rs17157887 chr10:46020348 G/C cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg17971929 chr21:40555470 PSMG1 -0.59 -7.77 -0.43 1.76e-13 Menarche (age at onset); CESC cis rs7666738 0.830 rs10001479 chr4:98918764 A/G cg17366294 chr4:99064904 C4orf37 -0.55 -7.39 -0.41 1.95e-12 Colonoscopy-negative controls vs population controls; CESC cis rs16973500 0.808 rs112452788 chr16:71911198 C/T cg09427745 chr16:71932006 KIAA0174 -0.51 -5.05 -0.3 8.42e-7 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs8070740 1.000 rs8066928 chr17:5328155 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.53 6.37 0.36 8.15e-10 Menopause (age at onset); CESC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg12311346 chr5:56204834 C5orf35 0.8 9.68 0.51 3.71e-19 Initial pursuit acceleration; CESC cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg03709012 chr19:19516395 GATAD2A 1.01 15.55 0.69 3.38e-39 Tonsillectomy; CESC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg00149659 chr3:10157352 C3orf10 0.7 8.38 0.46 3.2e-15 Alzheimer's disease; CESC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.21 0.53 7.28e-21 Prudent dietary pattern; CESC cis rs12190007 0.547 rs3006178 chr6:169823936 G/A cg15038512 chr6:170123185 PHF10 -0.5 -6.99 -0.39 2.22e-11 Obesity-related traits; CESC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg11494091 chr17:61959527 GH2 0.73 12.48 0.61 2.02e-28 Prudent dietary pattern; CESC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg05863683 chr7:1912471 MAD1L1 0.48 7.4 0.41 1.79e-12 Bipolar disorder and schizophrenia; CESC cis rs11098499 0.505 rs75122014 chr4:120362426 G/C cg09307838 chr4:120376055 NA 0.94 13.69 0.64 1.22e-32 Corneal astigmatism; CESC cis rs4555082 0.957 rs10140586 chr14:105749582 A/G cg27165867 chr14:105738592 BRF1 -0.47 -5.37 -0.31 1.69e-7 Mean platelet volume;Platelet distribution width; CESC cis rs1707322 0.896 rs946528 chr1:46485562 C/T cg06784218 chr1:46089804 CCDC17 -0.31 -5.38 -0.31 1.66e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04996668 chr22:24093433 ZNF70 0.56 6.42 0.37 6.14e-10 Gut microbiome composition (summer); CESC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg24250549 chr1:154909240 PMVK 0.63 8.87 0.48 1.08e-16 Prostate cancer; CESC cis rs10392 0.543 rs59777567 chr20:37557548 A/G cg27552599 chr20:37590471 DHX35 0.41 6.08 0.35 4.15e-9 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27226920 chr20:2733318 EBF4 -0.44 -6.32 -0.36 1.09e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6446731 0.500 rs2858085 chr4:3271226 T/G cg08886695 chr4:3369023 RGS12 0.39 5.59 0.33 5.5e-8 Mean platelet volume; CESC cis rs9467711 0.539 rs34436535 chr6:26370365 G/C cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs453301 0.606 rs7462373 chr8:8899318 G/C cg06636001 chr8:8085503 FLJ10661 -0.42 -5.14 -0.3 5.39e-7 Joint mobility (Beighton score); CESC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg14393609 chr7:65229607 NA 0.52 7.02 0.4 1.81e-11 Aortic root size; CESC cis rs593982 0.920 rs521678 chr11:65485727 T/G cg08755490 chr11:65554678 OVOL1 1.19 10.86 0.55 5.78e-23 Atopic dermatitis; CESC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg07701084 chr6:150067640 NUP43 0.43 5.85 0.34 1.45e-8 Lung cancer; CESC cis rs11785400 0.793 rs9297969 chr8:143723237 A/G cg24634471 chr8:143751801 JRK 0.46 5.82 0.34 1.73e-8 Schizophrenia; CESC cis rs4243830 1.000 rs34757678 chr1:6583270 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.71 6.02 0.35 5.91e-9 Body mass index; CESC cis rs6546550 0.869 rs6712827 chr2:70156540 C/G cg02498382 chr2:70120550 SNRNP27 -0.39 -6.83 -0.39 5.64e-11 Prevalent atrial fibrillation; CESC cis rs10752881 1.000 rs10752885 chr1:182982878 C/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.26 0.63 4.09e-31 Colorectal cancer; CESC cis rs67478160 0.634 rs941473 chr14:104201869 C/G cg08213375 chr14:104286397 PPP1R13B 0.45 8.6 0.47 7.26e-16 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12065272 chr1:245028125 HNRNPU 0.45 6.11 0.35 3.53e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6942756 0.774 rs2566876 chr7:128890055 A/G cg02491457 chr7:128862824 NA 0.65 9.65 0.51 4.39e-19 White matter hyperintensity burden; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18436758 chr1:21113190 HP1BP3 0.55 6.2 0.36 2.11e-9 Gut microbiome composition (summer); CESC cis rs6582630 0.555 rs10880602 chr12:38505660 T/C cg13010199 chr12:38710504 ALG10B 0.42 5.5 0.32 9.16e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs763512 0.504 rs11652399 chr17:35869781 G/T cg16670864 chr17:35848621 DUSP14 0.5 6.16 0.35 2.66e-9 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg26752003 chr8:145688521 CYHR1 -0.42 -5.53 -0.32 7.75e-8 Age at first birth; CESC cis rs2777491 0.574 rs2730056 chr15:41735785 A/G cg20272979 chr15:41787780 ITPKA 0.42 5.14 0.3 5.47e-7 Ulcerative colitis; CESC cis rs4523957 0.928 rs170045 chr17:2196905 A/G cg16513277 chr17:2031491 SMG6 0.59 8.08 0.44 2.29e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs524281 0.861 rs10896090 chr11:65945186 A/G cg14036092 chr11:66035641 RAB1B -0.54 -5.03 -0.3 9.2e-7 Electroencephalogram traits; CESC cis rs10779751 0.770 rs2258621 chr1:11141187 C/G cg08854313 chr1:11322531 MTOR 0.74 8.78 0.47 2.09e-16 Body mass index; CESC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.55 0.32 6.85e-8 Electroencephalogram traits; CESC cis rs12699921 0.933 rs6942635 chr7:17987865 A/G cg03009463 chr7:17980271 SNX13 0.38 5.06 0.3 7.96e-7 Fibrinogen levels; CESC cis rs73206853 0.609 rs55833146 chr12:110872335 A/G cg12870014 chr12:110450643 ANKRD13A 0.62 5.09 0.3 6.71e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs910316 0.737 rs175084 chr14:75519175 C/T cg08847533 chr14:75593920 NEK9 -0.91 -15.66 -0.69 1.43e-39 Height; CESC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg12463550 chr7:65579703 CRCP 0.49 6.26 0.36 1.56e-9 Aortic root size; CESC cis rs911555 0.723 rs12894652 chr14:103926024 A/G cg12935359 chr14:103987150 CKB 0.66 9.58 0.51 7.28e-19 Intelligence (multi-trait analysis); CESC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg20887711 chr4:1340912 KIAA1530 0.54 7.47 0.42 1.15e-12 Longevity; CESC cis rs763121 0.853 rs5757181 chr22:39013522 G/A cg14440974 chr22:39074834 NA -0.39 -5.14 -0.3 5.34e-7 Menopause (age at onset); CESC cis rs9911578 1.000 rs654778 chr17:56736473 A/C cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg03188948 chr7:1209495 NA 0.73 7.05 0.4 1.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7586673 0.930 rs6432667 chr2:161905001 T/C cg21518248 chr2:162101506 NA 0.5 6.52 0.37 3.6e-10 Intelligence (multi-trait analysis); CESC cis rs16917546 1.000 rs10995250 chr10:64396921 G/A cg03961010 chr10:64397487 ZNF365 -0.37 -6.06 -0.35 4.7e-9 Basal cell carcinoma; CESC cis rs2180341 0.576 rs2057224 chr6:127624414 C/G cg24812749 chr6:127587940 RNF146 0.6 8.1 0.45 1.97e-14 Breast cancer; CESC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.48 -0.32 9.71e-8 Lung cancer; CESC cis rs4144743 0.938 rs35439279 chr17:45321694 C/T cg18085866 chr17:45331354 ITGB3 -0.65 -7.15 -0.4 8.53e-12 Body mass index; CESC cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg18769074 chr3:133464867 TF 0.3 5.7 0.33 3.12e-8 Iron status biomarkers (transferrin levels); CESC cis rs7762018 0.769 rs7766146 chr6:170070135 A/T cg13891659 chr6:170190454 C6orf122;C6orf208 0.57 5.51 0.32 8.63e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9457247 0.935 rs427824 chr6:167403918 T/G cg25258033 chr6:167368657 RNASET2 0.38 5.77 0.33 2.23e-8 Crohn's disease; CESC trans rs9467711 0.538 rs35942482 chr6:26444938 T/A cg06606381 chr12:133084897 FBRSL1 -0.82 -6.76 -0.38 9.01e-11 Autism spectrum disorder or schizophrenia; CESC cis rs7017914 0.967 rs1493198 chr8:71851957 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.16 -0.3 4.74e-7 Bone mineral density; CESC cis rs950776 0.518 rs62008174 chr15:78808947 C/T cg24631222 chr15:78858424 CHRNA5 -0.4 -5.03 -0.3 9.02e-7 Sudden cardiac arrest; CESC cis rs7917772 0.536 rs11191361 chr10:104411958 C/T cg22532475 chr10:104410764 TRIM8 -0.43 -6.68 -0.38 1.39e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00164301 chr17:80351457 C17orf101 0.41 6.16 0.35 2.71e-9 Fibrinogen levels; CESC cis rs10979 0.838 rs12208649 chr6:143893321 G/T cg25407410 chr6:143891975 LOC285740 -0.61 -9.21 -0.49 1.01e-17 Hypospadias; CESC cis rs2302190 0.882 rs12942018 chr17:56613277 C/T cg25885038 chr17:56607967 SEPT4 -0.42 -5.69 -0.33 3.33e-8 Vitamin D levels; CESC trans rs13098911 0.540 rs17330872 chr3:46035097 A/G cg10236987 chr1:228114221 WNT9A 0.66 6.54 0.37 3.11e-10 Celiac disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06148997 chr2:107084783 RGPD3 0.43 6.03 0.35 5.61e-9 Fibrinogen levels; CESC cis rs6424115 0.708 rs11803575 chr1:24182348 A/T cg15997130 chr1:24165203 NA -0.4 -5.06 -0.3 7.96e-7 Immature fraction of reticulocytes; CESC cis rs4975616 0.714 rs37007 chr5:1352372 G/C cg06550200 chr5:1325588 CLPTM1L -0.65 -9.79 -0.52 1.63e-19 Lung cancer; CESC trans rs7615952 0.599 rs12485717 chr3:125707075 C/T cg07211511 chr3:129823064 LOC729375 0.55 6.28 0.36 1.35e-9 Blood pressure (smoking interaction); CESC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg14926445 chr8:58193284 C8orf71 -0.52 -5.59 -0.32 5.77e-8 Developmental language disorder (linguistic errors); CESC cis rs1153858 1.000 rs66939267 chr15:45676902 T/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg15782153 chr7:917662 C7orf20 -0.47 -5.04 -0.3 8.47e-7 Cerebrospinal P-tau181p levels; CESC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg01763666 chr17:80159506 CCDC57 0.37 5.14 0.3 5.38e-7 Life satisfaction; CESC cis rs72945132 0.882 rs7116059 chr11:70159690 G/T cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg12311346 chr5:56204834 C5orf35 -0.57 -7.57 -0.42 6.09e-13 Coronary artery disease; CESC cis rs12477438 0.520 rs11890338 chr2:99767868 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.81 0.7 4.17e-40 Chronic sinus infection; CESC trans rs11264799 0.765 rs66931510 chr1:157635085 C/T cg22691776 chr3:15032403 NR2C2 0.33 6.1 0.35 3.79e-9 IgA nephropathy; CESC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 6.86 0.39 4.74e-11 Melanoma; CESC cis rs12824058 0.831 rs4759655 chr12:130815740 A/G cg23887609 chr12:130822674 PIWIL1 -0.47 -6.09 -0.35 3.96e-9 Menopause (age at onset); CESC cis rs4780401 0.567 rs34340800 chr16:11779318 G/A cg01061890 chr16:11836724 TXNDC11 -0.45 -5.63 -0.33 4.67e-8 Rheumatoid arthritis; CESC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg11905131 chr22:24372483 LOC391322 -0.74 -10.92 -0.56 3.66e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg01181863 chr3:195395398 SDHAP2 -0.54 -6.25 -0.36 1.63e-9 Pancreatic cancer; CESC cis rs9902453 0.838 rs3110495 chr17:27978455 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -8.62 -0.47 6.1e-16 Coffee consumption (cups per day); CESC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.23 0.41 5.08e-12 Intelligence (multi-trait analysis); CESC trans rs877282 0.898 rs11253346 chr10:765313 A/G cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg04282206 chr17:62833786 PLEKHM1P 0.55 6.36 0.36 8.57e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs933688 1.000 rs10059163 chr5:90742444 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.96 12.76 0.62 2.16e-29 Smoking behavior; CESC cis rs8060686 0.841 rs56374641 chr16:67908713 G/T cg26727032 chr16:67993705 SLC12A4 -0.6 -6.82 -0.39 6.03e-11 HDL cholesterol;Metabolic syndrome; CESC cis rs3617 0.625 rs2240917 chr3:52851137 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.73 0.33 2.8e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs1401999 1.000 rs939338 chr3:183704068 A/G cg01324343 chr3:183735012 ABCC5 -0.63 -13.64 -0.64 1.94e-32 Anterior chamber depth; CESC cis rs9611565 0.559 rs739136 chr22:42100275 C/T cg06634786 chr22:41940651 POLR3H -0.69 -6.91 -0.39 3.58e-11 Vitiligo; CESC cis rs7116495 0.881 rs676721 chr11:71770638 G/A cg26138937 chr11:71823887 C11orf51 -0.84 -6.98 -0.39 2.33e-11 Severe influenza A (H1N1) infection; CESC cis rs796364 0.813 rs7565417 chr2:201057491 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.6 6.05 0.35 5.03e-9 Schizophrenia; CESC cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -8.16 -0.45 1.33e-14 Hemoglobin concentration; CESC cis rs2806561 0.765 rs605367 chr1:23518524 T/C cg12483005 chr1:23474871 LUZP1 0.37 5.89 0.34 1.15e-8 Height; CESC cis rs7833986 0.501 rs2719226 chr8:57044066 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.45 0.42 1.35e-12 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12366118 chr12:62860687 MON2 -0.43 -6.14 -0.35 2.97e-9 Gambling; CESC cis rs17376456 0.825 rs17314825 chr5:93234937 A/G cg21475434 chr5:93447410 FAM172A 0.74 6.68 0.38 1.42e-10 Diabetic retinopathy; CESC cis rs4253772 0.591 rs11704614 chr22:46691936 A/G cg18190219 chr22:46762943 CELSR1 -0.59 -5.45 -0.32 1.14e-7 LDL cholesterol;Cholesterol, total; CESC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.15e-9 Menopause (age at onset); CESC cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg23711669 chr6:146136114 FBXO30 0.97 14.77 0.67 2.05e-36 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13325346 chr17:37353483 CACNB1 -0.53 -6.41 -0.37 6.48e-10 Gut microbiome composition (summer); CESC cis rs60733400 0.818 rs10909839 chr1:2708430 G/A cg18854424 chr1:2615690 NA 0.31 5.79 0.34 1.98e-8 Multiple sclerosis; CESC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg07507251 chr3:52567010 NT5DC2 0.33 5.4 0.31 1.49e-7 Bipolar disorder; CESC cis rs2290720 0.930 rs7301458 chr12:101747562 T/G cg22051763 chr12:101673672 UTP20 -0.49 -6.04 -0.35 5.28e-9 Brain structure (hippocampal volume); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16029838 chr7:44530503 NUDCD3 0.6 7.21 0.4 5.69e-12 Gut microbiome composition (summer); CESC cis rs6142102 0.602 rs2268079 chr20:32596750 A/G cg08999081 chr20:33150536 PIGU 0.33 5.05 0.3 8.33e-7 Skin pigmentation; CESC cis rs6582630 0.502 rs11522899 chr12:38270637 T/C cg26384229 chr12:38710491 ALG10B 0.72 10.26 0.53 5.3e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs412000 0.560 rs4793583 chr17:56451407 A/C cg12560992 chr17:57184187 TRIM37 -0.82 -12.98 -0.62 3.76e-30 Primary tooth development (time to first tooth eruption); CESC cis rs3862030 0.839 rs7078511 chr10:104283874 C/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.38 -5.26 -0.31 2.92e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg21963583 chr11:68658836 MRPL21 0.44 6.04 0.35 5.19e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7659604 0.540 rs34445121 chr4:122710889 G/A cg19671926 chr4:122722719 EXOSC9 0.67 8.89 0.48 9.9900000000000006e-17 Type 2 diabetes; CESC cis rs11997175 0.545 rs7388496 chr8:33667898 A/G ch.8.33884649F chr8:33765107 NA 0.44 5.28 0.31 2.72e-7 Body mass index; CESC cis rs7520050 0.771 rs4660882 chr1:46116292 C/T cg06784218 chr1:46089804 CCDC17 0.33 6.06 0.35 4.56e-9 Red blood cell count;Reticulocyte count; CESC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.29e-8 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08030134 chr16:85813931 COX4NB -0.5 -6.14 -0.35 3.05e-9 Gut microbiome composition (summer); CESC cis rs832540 0.931 rs832534 chr5:56213672 G/A cg12311346 chr5:56204834 C5orf35 -0.42 -5.21 -0.3 3.88e-7 Coronary artery disease; CESC cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg00409905 chr10:38381863 ZNF37A -0.48 -6.39 -0.37 7.55e-10 Extrinsic epigenetic age acceleration; CESC cis rs6541297 0.645 rs648456 chr1:230311918 G/A cg20703242 chr1:230279135 GALNT2 -0.43 -5.59 -0.32 5.66e-8 Coronary artery disease; CESC cis rs644799 0.965 rs534488 chr11:95562327 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.57e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs66561647 0.661 rs7387614 chr8:128929353 C/T cg05480350 chr8:128972681 MIR1205;PVT1 0.39 5.19 0.3 4.18e-7 Hemoglobin concentration; CESC cis rs10206020 0.885 rs11899557 chr2:1576123 G/T cg12573674 chr2:1569213 NA -0.46 -5.2 -0.3 3.96e-7 IgG glycosylation; CESC cis rs4523957 0.583 rs2984939 chr17:2023965 T/C cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9811920 0.609 rs793460 chr3:99615733 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs9457247 0.534 rs9366078 chr6:167399512 A/G cg23791538 chr6:167370224 RNASET2 0.67 9.68 0.51 3.65e-19 Crohn's disease; CESC cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs5167 0.504 rs3760628 chr19:45457225 G/A cg09555818 chr19:45449301 APOC2 0.41 6.54 0.37 3.08e-10 Blood protein levels; CESC cis rs911555 0.755 rs975892 chr14:103883349 A/T cg12935359 chr14:103987150 CKB -0.6 -8.86 -0.48 1.2e-16 Intelligence (multi-trait analysis); CESC cis rs17854409 1.000 rs66956644 chr20:61484499 T/C cg07645718 chr20:61493192 TCFL5 0.81 5.2 0.3 4.03e-7 Obesity-related traits; CESC cis rs7474896 0.515 rs2738208 chr10:38306128 A/G cg25427524 chr10:38739819 LOC399744 0.49 5.56 0.32 6.5e-8 Obesity (extreme); CESC cis rs710216 0.957 rs859511 chr1:43430260 C/T cg03128534 chr1:43423976 SLC2A1 0.54 6.3 0.36 1.21e-9 Red cell distribution width; CESC cis rs12545109 0.800 rs1467125 chr8:57418638 C/T cg09654669 chr8:57350985 NA -0.55 -6.58 -0.37 2.56e-10 Obesity-related traits; CESC trans rs877282 0.853 rs10904545 chr10:757100 G/A cg22713356 chr15:30763199 NA 0.95 8.36 0.46 3.67e-15 Uric acid levels; CESC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs77972916 0.561 rs10167415 chr2:43552460 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.6 -5.32 -0.31 2.19e-7 Granulocyte percentage of myeloid white cells; CESC cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg24549020 chr5:56110836 MAP3K1 -0.52 -6.46 -0.37 4.87e-10 Initial pursuit acceleration; CESC cis rs6060717 0.610 rs1891151 chr20:34612726 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -5.17 -0.3 4.71e-7 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.32 0.31 2.23e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7084402 0.967 rs2438182 chr10:60314815 A/T cg07615347 chr10:60278583 BICC1 0.61 9.59 0.51 7.04e-19 Refractive error; CESC cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 6.58 0.37 2.45e-10 Personality dimensions; CESC cis rs10905065 1.000 rs10905065 chr10:5769827 C/T cg11519256 chr10:5708881 ASB13 0.44 5.94 0.34 8.88e-9 Menopause (age at onset); CESC cis rs920590 0.684 rs57462676 chr8:19670848 G/C cg17834443 chr8:19674713 INTS10 0.55 6.09 0.35 3.85e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs3857067 1.000 rs6532463 chr4:95027048 G/T cg11021082 chr4:95130006 SMARCAD1 -0.53 -8.12 -0.45 1.77e-14 QT interval; CESC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg11663144 chr21:46675770 NA -0.47 -6.99 -0.39 2.27e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03131298 chr16:31580889 CSDAP1 -0.47 -6.11 -0.35 3.59e-9 Gut microbiome composition (summer); CESC cis rs9300255 0.510 rs1727323 chr12:123698790 T/C cg05973401 chr12:123451056 ABCB9 0.49 5.63 0.33 4.63e-8 Neutrophil percentage of white cells; CESC cis rs3806933 0.522 rs13153937 chr5:110434307 C/T cg04022379 chr5:110408740 TSLP 0.48 7.95 0.44 5.23e-14 Eosinophilic esophagitis; CESC cis rs2832077 0.527 rs9981922 chr21:30212718 A/G cg08807101 chr21:30365312 RNF160 -0.64 -8.28 -0.45 5.94e-15 Cognitive test performance; CESC cis rs7923452 0.507 rs612802 chr10:30756441 G/A cg25182066 chr10:30743637 MAP3K8 -0.51 -7.16 -0.4 7.9e-12 Itch intensity from mosquito bite; CESC cis rs2120019 0.608 rs8042558 chr15:75320433 G/T cg09165964 chr15:75287851 SCAMP5 -0.8 -10.86 -0.56 5.61e-23 Blood trace element (Zn levels); CESC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg19539972 chr4:7069911 GRPEL1 0.77 9.17 0.49 1.37e-17 Monocyte percentage of white cells; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg01840591 chr16:19179931 SYT17 -0.46 -6.33 -0.36 1.04e-9 Asthma; CESC cis rs708547 0.836 rs1315005 chr4:57858237 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.77 10.29 0.53 4.12e-21 Response to bleomycin (chromatid breaks); CESC cis rs7916697 0.593 rs7912895 chr10:70021498 A/G cg06988349 chr10:69991859 ATOH7 0.32 5.19 0.3 4.12e-7 Optic disc area; CESC cis rs9549367 0.636 rs486407 chr13:113833499 G/A cg18105134 chr13:113819100 PROZ 0.55 7.12 0.4 1.04e-11 Platelet distribution width; CESC cis rs9303401 0.614 rs62084384 chr17:57126842 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.57 0.61 9.48e-29 Cognitive test performance; CESC cis rs9902453 0.834 rs9901694 chr17:28271645 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 8.8 0.48 1.79e-16 Coffee consumption (cups per day); CESC cis rs2486288 0.656 rs2413768 chr15:45561984 A/G cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.46 -0.37 4.99e-10 Glomerular filtration rate; CESC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg25072359 chr17:41440525 NA 0.51 6.64 0.38 1.77e-10 Menopause (age at onset); CESC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg12463550 chr7:65579703 CRCP 0.49 6.35 0.36 9.51e-10 Aortic root size; CESC cis rs6120849 0.573 rs3746429 chr20:33703607 A/G cg24642439 chr20:33292090 TP53INP2 -0.72 -6.79 -0.38 7.52e-11 Protein C levels; CESC cis rs1983170 1.000 rs12563578 chr1:91993702 T/C cg21854759 chr1:92012499 NA 0.52 5.6 0.33 5.45e-8 Eosinophil percentage of white cells; CESC trans rs1973993 0.745 rs7512263 chr1:96941158 C/A cg10631902 chr5:14652156 NA -0.47 -6.18 -0.35 2.43e-9 Weight; CESC cis rs4363385 0.773 rs310122 chr1:153064288 C/T cg22204954 chr1:153085998 SPRR2F -0.4 -5.54 -0.32 7.43e-8 Inflammatory skin disease; CESC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg08027265 chr7:2291960 NA -0.49 -7.48 -0.42 1.09e-12 Bipolar disorder and schizophrenia; CESC cis rs11122272 0.705 rs2486731 chr1:231532511 C/T cg06096015 chr1:231504339 EGLN1 -0.38 -5.54 -0.32 7.3e-8 Hemoglobin concentration; CESC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.97 0.48 5.62e-17 Bipolar disorder; CESC cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg12292205 chr6:26970375 C6orf41 -0.54 -5.98 -0.34 7.34e-9 Intelligence (multi-trait analysis); CESC cis rs2242116 0.932 rs4683301 chr3:46931478 A/T cg27129171 chr3:47204927 SETD2 -0.38 -5.39 -0.31 1.53e-7 Birth weight; CESC cis rs72627123 0.749 rs10149956 chr14:74649106 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 -0.75 -5.25 -0.31 3.11e-7 Morning vs. evening chronotype; CESC trans rs61931739 0.500 rs11053197 chr12:34441949 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.28 0.36 1.38e-9 Morning vs. evening chronotype; CESC cis rs892961 0.932 rs7223768 chr17:75410521 G/A cg05865280 chr17:75406074 SEPT9 0.61 12.53 0.61 1.38e-28 Airflow obstruction; CESC cis rs4970966 0.951 rs11204682 chr1:150595537 G/T cg13175981 chr1:150552382 MCL1 0.6 6.22 0.36 1.95e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs11785400 0.793 rs9297969 chr8:143723237 A/G cg10596483 chr8:143751796 JRK 0.42 5.36 0.31 1.77e-7 Schizophrenia; CESC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs4547160 0.888 rs10877953 chr12:63488462 C/T cg26727693 chr12:63544175 AVPR1A 0.43 6.35 0.36 9.56e-10 Morning vs. evening chronotype; CESC cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg10556349 chr10:835070 NA 0.55 5.41 0.32 1.44e-7 Eosinophil percentage of granulocytes; CESC cis rs7927592 0.763 rs10896327 chr11:68235275 G/C cg01657329 chr11:68192670 LRP5 -0.47 -6.19 -0.36 2.29e-9 Total body bone mineral density; CESC cis rs2439831 0.867 rs2412780 chr15:43655794 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.93 11.25 0.57 2.98e-24 Lung cancer in ever smokers; CESC cis rs7312933 0.607 rs7965392 chr12:42540280 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 5.95 0.34 8.64e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg01171360 chr6:293285 DUSP22 -0.67 -8.64 -0.47 5.47e-16 Menopause (age at onset); CESC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg22535103 chr8:58192502 C8orf71 0.9 9.48 0.5 1.54e-18 Developmental language disorder (linguistic errors); CESC cis rs710216 0.843 rs844501 chr1:43440783 G/A cg22176566 chr1:43424700 SLC2A1 0.48 5.16 0.3 4.86e-7 Red cell distribution width; CESC cis rs9291683 0.526 rs12506122 chr4:10033538 C/A cg11266682 chr4:10021025 SLC2A9 0.66 12.66 0.61 4.64e-29 Bone mineral density; CESC cis rs17433780 0.857 rs12140979 chr1:89467242 C/G cg09516651 chr1:89888402 LOC400759 0.67 8.98 0.48 5.18e-17 Carotid intima media thickness; CESC cis rs754466 0.651 rs55738779 chr10:79652395 C/T cg17075019 chr10:79541650 NA -0.83 -11.79 -0.59 4.62e-26 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1707322 0.752 rs4607935 chr1:46117161 C/T cg05343316 chr1:45956843 TESK2 0.51 6.24 0.36 1.7e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9399135 0.967 rs6902438 chr6:135336587 C/T cg24558204 chr6:135376177 HBS1L 0.52 7.18 0.4 7.05e-12 Red blood cell count; CESC cis rs8028182 0.549 rs56395816 chr15:75664571 A/T cg20655648 chr15:75932815 IMP3 -0.46 -5.72 -0.33 2.87e-8 Sudden cardiac arrest; CESC cis rs2404602 0.574 rs4886795 chr15:76642218 G/C cg00316803 chr15:76480434 C15orf27 0.44 5.86 0.34 1.37e-8 Blood metabolite levels; CESC cis rs17445774 1.000 rs17445774 chr2:200859249 A/G cg23649088 chr2:200775458 C2orf69 -0.64 -7.24 -0.41 4.97e-12 LDL cholesterol to HDL cholesterol ratio; CESC cis rs12681288 0.676 rs2701914 chr8:999935 C/T cg04851639 chr8:1020857 NA -0.32 -6.86 -0.39 4.9e-11 Schizophrenia; CESC cis rs17270561 1.000 rs17270561 chr6:25820439 A/C cg16482183 chr6:26056742 HIST1H1C -0.51 -5.86 -0.34 1.37e-8 Iron status biomarkers; CESC cis rs977987 0.778 rs4887821 chr16:75398574 G/A cg03315344 chr16:75512273 CHST6 0.39 5.63 0.33 4.61e-8 Dupuytren's disease; CESC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg18876405 chr7:65276391 NA 0.5 6.68 0.38 1.43e-10 Aortic root size; CESC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg19318889 chr4:1322082 MAEA 0.62 7.59 0.42 5.56e-13 Longevity; CESC cis rs7223966 1.000 rs11657120 chr17:61857218 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.73 0.38 1.06e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.47 5.59 0.32 5.74e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs7819412 0.594 rs7460507 chr8:10969075 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -6.97 -0.39 2.56e-11 Triglycerides; CESC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Parkinson's disease; CESC cis rs67478160 0.608 rs11160760 chr14:104248938 G/T cg01849466 chr14:104193079 ZFYVE21 -0.52 -7.18 -0.4 7.16e-12 Schizophrenia; CESC cis rs6120849 0.802 rs6087682 chr20:33752897 A/T cg24642439 chr20:33292090 TP53INP2 0.61 6.49 0.37 4.21e-10 Protein C levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15658577 chr2:179319711 DFNB59;MIR548N 0.52 6.78 0.38 7.94e-11 Fibrinogen levels; CESC cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg14829155 chr15:31115871 NA 0.67 7.34 0.41 2.58e-12 Huntington's disease progression; CESC cis rs7927771 0.524 rs7943213 chr11:47715524 T/C cg20307385 chr11:47447363 PSMC3 0.61 8.46 0.46 1.82e-15 Subjective well-being; CESC cis rs7084402 0.967 rs1649015 chr10:60289031 A/G cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg18099408 chr3:52552593 STAB1 -0.33 -5.47 -0.32 1.02e-7 Bipolar disorder; CESC cis rs9581857 0.685 rs9319372 chr13:28042796 C/T cg01674679 chr13:27998804 GTF3A 0.67 5.43 0.32 1.26e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7542091 0.739 rs10863793 chr1:210037420 G/A cg22029157 chr1:209979665 IRF6 0.47 7.0 0.39 2.15e-11 Monobrow; CESC cis rs11577318 0.853 rs12743998 chr1:26629882 G/A cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.46 -0.37 5.05e-10 Granulocyte percentage of myeloid white cells; CESC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.08e-9 Aortic root size; CESC cis rs4654899 0.931 rs1152998 chr1:21124290 C/T cg05370193 chr1:21551575 ECE1 0.37 5.42 0.32 1.32e-7 Superior frontal gyrus grey matter volume; CESC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs506597 0.920 rs221770 chr7:100302094 A/T cg10426581 chr7:100472382 SRRT 0.61 5.23 0.31 3.52e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs1018836 0.631 rs2205157 chr8:91472384 C/T cg16814680 chr8:91681699 NA -0.52 -6.92 -0.39 3.38e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs68170813 0.641 rs12532953 chr7:106865920 C/T cg02696742 chr7:106810147 HBP1 -0.52 -5.08 -0.3 7.2e-7 Coronary artery disease; CESC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg18016565 chr1:150552671 MCL1 0.34 5.22 0.31 3.63e-7 Tonsillectomy; CESC cis rs11577318 0.853 rs4526602 chr1:26648034 C/T cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.41 -0.37 6.69e-10 Granulocyte percentage of myeloid white cells; CESC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg11494091 chr17:61959527 GH2 0.76 13.48 0.64 6.83e-32 Prudent dietary pattern; CESC cis rs1707322 0.752 rs10430105 chr1:46138876 G/A cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3820068 0.603 rs998032 chr1:15989918 T/C cg16988262 chr1:15930761 NA 0.34 5.59 0.32 5.64e-8 Systolic blood pressure; CESC cis rs2073300 0.609 rs77673953 chr20:23398794 G/C cg16736954 chr20:23401023 NAPB 0.77 5.7 0.33 3.12e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs372883 0.600 rs1236460 chr21:30615513 G/A cg08807101 chr21:30365312 RNF160 -0.5 -5.87 -0.34 1.33e-8 Pancreatic cancer; CESC cis rs6088619 1.000 rs6088619 chr20:33411871 A/G cg08999081 chr20:33150536 PIGU 0.68 5.86 0.34 1.35e-8 Hip circumference adjusted for BMI; CESC cis rs1348850 0.645 rs10181259 chr2:178428256 C/A cg23306229 chr2:178417860 TTC30B 0.75 8.31 0.45 5.11e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg18032046 chr6:28092343 ZSCAN16 -0.48 -6.22 -0.36 1.92e-9 Cardiac Troponin-T levels; CESC cis rs9611565 0.592 rs8779 chr22:42070276 T/C cg06634786 chr22:41940651 POLR3H 0.62 6.25 0.36 1.67e-9 Vitiligo; CESC cis rs780096 0.647 rs11682083 chr2:27752296 A/G cg21248554 chr2:27665150 KRTCAP3 -0.32 -6.35 -0.36 9.28e-10 Total body bone mineral density; CESC cis rs9399135 0.967 rs6925424 chr6:135313948 T/A cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs2243480 1.000 rs73150014 chr7:65450919 A/C cg13147721 chr7:65941812 NA -0.9 -8.73 -0.47 2.9e-16 Diabetic kidney disease; CESC cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg06212747 chr3:49208901 KLHDC8B 0.65 8.81 0.48 1.68e-16 Parkinson's disease; CESC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg02711726 chr17:80685570 FN3KRP -0.43 -5.56 -0.32 6.61e-8 Glycated hemoglobin levels; CESC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg11247378 chr22:39784982 NA -0.59 -8.94 -0.48 6.6e-17 Intelligence (multi-trait analysis); CESC cis rs6466055 0.720 rs7800928 chr7:105007470 T/C cg04380332 chr7:105027541 SRPK2 -0.42 -5.47 -0.32 1.02e-7 Schizophrenia; CESC cis rs3793683 0.571 rs12781152 chr10:134590257 G/C cg27297192 chr10:134578999 INPP5A 0.39 5.16 0.3 4.75e-7 Migraine; CESC cis rs2295359 0.892 rs4655687 chr1:67649946 C/T cg17031739 chr1:67600172 NA 0.4 5.2 0.3 4.05e-7 Psoriasis; CESC cis rs832540 0.519 rs6895442 chr5:56260998 T/C cg24531977 chr5:56204891 C5orf35 -0.43 -5.31 -0.31 2.34e-7 Coronary artery disease; CESC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg08736216 chr1:53307985 ZYG11A 0.36 6.32 0.36 1.09e-9 Monocyte count; CESC trans rs4950322 0.518 rs55697094 chr1:146592787 T/C cg04954894 chr8:38089920 DDHD2 -0.6 -6.47 -0.37 4.75e-10 Protein quantitative trait loci; CESC cis rs7824557 0.628 rs7831346 chr8:11193530 C/T cg21775007 chr8:11205619 TDH 0.55 8.74 0.47 2.75e-16 Retinal vascular caliber; CESC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg09699651 chr6:150184138 LRP11 0.39 5.04 0.3 8.83e-7 Lung cancer; CESC cis rs8180040 0.764 rs12629262 chr3:47196580 C/T cg27129171 chr3:47204927 SETD2 0.69 10.44 0.54 1.33e-21 Colorectal cancer; CESC cis rs4132509 1.000 rs57824597 chr1:243930399 C/T cg21452805 chr1:244014465 NA 0.52 6.37 0.36 8.35e-10 RR interval (heart rate); CESC cis rs2795502 0.938 rs2744085 chr10:43341976 C/T cg20628663 chr10:43360327 NA 0.57 6.85 0.39 5.02e-11 Blood protein levels; CESC cis rs11098499 0.542 rs7677836 chr4:120310638 T/A cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs6866344 0.697 rs11743893 chr5:178125194 C/T cg03877680 chr5:178157825 ZNF354A 0.67 7.87 0.44 9.2e-14 Neutrophil percentage of white cells; CESC cis rs1129187 0.837 rs4714634 chr6:42901120 G/A cg24101359 chr6:42928495 GNMT 0.61 8.82 0.48 1.55e-16 Alzheimer's disease in APOE e4+ carriers; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24883605 chr17:79508142 C17orf70 0.45 6.1 0.35 3.65e-9 Fibrinogen levels; CESC cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg10523679 chr1:76189770 ACADM 0.79 10.91 0.56 3.81e-23 Blood metabolite levels;Acylcarnitine levels; CESC cis rs858239 0.965 rs156429 chr7:23306020 A/G cg23682824 chr7:23144976 KLHL7 0.38 5.09 0.3 6.85e-7 Cerebrospinal fluid biomarker levels; CESC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg22903657 chr4:1355424 KIAA1530 -0.38 -5.23 -0.31 3.48e-7 Obesity-related traits; CESC trans rs1728785 1.000 rs11648314 chr16:68596775 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.71 8.6 0.47 7.11e-16 Ulcerative colitis; CESC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg18876405 chr7:65276391 NA 0.7 9.79 0.52 1.65e-19 Calcium levels; CESC cis rs1400745 0.756 rs3783316 chr14:35337192 A/G cg16230307 chr14:35515116 FAM177A1 0.44 5.25 0.31 3.18e-7 Monocyte count; CESC cis rs2425143 1.000 rs11700256 chr20:34372941 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.69 5.94 0.34 9.08e-9 Blood protein levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25018755 chr22:43506952 BIK 0.5 6.65 0.38 1.65e-10 Gut microbiota (bacterial taxa); CESC cis rs9300255 0.569 rs1727320 chr12:123700476 T/A cg05973401 chr12:123451056 ABCB9 0.49 5.63 0.33 4.65e-8 Neutrophil percentage of white cells; CESC cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg08213375 chr14:104286397 PPP1R13B 0.31 5.1 0.3 6.45e-7 Reticulocyte count; CESC cis rs2456568 0.803 rs10765641 chr11:93640312 T/C cg26875233 chr11:93583750 C11orf90 -0.29 -5.07 -0.3 7.48e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.16 0.35 2.62e-9 Prudent dietary pattern; CESC cis rs6500602 0.929 rs9926114 chr16:4478322 C/G cg08645402 chr16:4508243 NA 0.4 6.03 0.35 5.44e-9 Schizophrenia; CESC cis rs1511802 0.666 rs13106826 chr4:187125168 T/A cg24794857 chr4:187113578 CYP4V2 0.46 6.08 0.35 4.23e-9 Blood protein levels; CESC cis rs2985684 0.625 rs4900931 chr14:50022793 A/T cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.41 -5.04 -0.3 8.68e-7 Carotid intima media thickness; CESC cis rs1008375 1.000 rs60178264 chr4:17685308 G/T cg16339924 chr4:17578868 LAP3 0.51 6.55 0.37 2.98e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg05564831 chr3:52568323 NT5DC2 0.45 6.8 0.39 6.82e-11 Bipolar disorder; CESC cis rs8050907 0.744 rs17137053 chr16:4524155 C/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs367943 1.000 rs348962 chr5:112819086 C/T cg12552261 chr5:112820674 MCC 0.61 7.85 0.43 1.05e-13 Type 2 diabetes; CESC cis rs4822044 0.680 rs8138780 chr22:42097462 A/T cg17376030 chr22:41985996 PMM1 -0.78 -8.3 -0.45 5.4e-15 Cannabis dependence symptom count; CESC trans rs11722228 0.522 rs73212880 chr4:10115692 T/A cg26043149 chr18:55253948 FECH 0.97 11.8 0.59 4.27e-26 Gout;Urate levels;Serum uric acid levels; CESC cis rs7267979 0.753 rs400357 chr20:25479058 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.76 13.71 0.64 1.05e-32 Liver enzyme levels (alkaline phosphatase); CESC cis rs902774 0.597 rs7299694 chr12:53352572 A/C cg14581129 chr12:53358946 NA -0.45 -6.05 -0.35 5.02e-9 Prostate cancer; CESC cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.62 0.33 4.87e-8 Personality dimensions; CESC cis rs863345 0.967 rs12041218 chr1:158481574 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -5.9 -0.34 1.14e-8 Pneumococcal bacteremia; CESC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.49 -6.33 -0.36 1.05e-9 Bipolar disorder; CESC cis rs10851478 0.872 rs4480740 chr15:49755842 A/G cg08060515 chr15:49448048 GALK2;COPS2 -0.43 -5.35 -0.31 1.87e-7 Oral cavity cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05973872 chr7:2293347 NA -0.52 -6.12 -0.35 3.4e-9 Gut microbiome composition (summer); CESC cis rs16975963 0.644 rs2290999 chr19:38138887 T/C cg14970273 chr19:37794573 NA -0.4 -5.08 -0.3 7.11e-7 Longevity; CESC cis rs17376456 0.825 rs10056879 chr5:93282218 C/A cg21475434 chr5:93447410 FAM172A 0.79 6.2 0.36 2.11e-9 Diabetic retinopathy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16249894 chr13:21141322 IFT88 -0.47 -6.05 -0.35 4.85e-9 Fibrinogen levels; CESC cis rs7267979 1.000 rs2257985 chr20:25269743 G/T cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg03609598 chr5:56110824 MAP3K1 -0.51 -5.5 -0.32 9.11e-8 Initial pursuit acceleration; CESC cis rs11122272 0.735 rs2749716 chr1:231486908 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -6.38 -0.36 7.94e-10 Hemoglobin concentration; CESC cis rs524023 0.957 rs893007 chr11:64365668 C/A cg07220939 chr11:64358617 SLC22A12 -0.37 -5.65 -0.33 4.19e-8 Urate levels in obese individuals; CESC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg25985355 chr7:65971099 NA 0.32 5.24 0.31 3.35e-7 Aortic root size; CESC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7116495 0.881 rs6592449 chr11:71670222 C/T cg26138937 chr11:71823887 C11orf51 -0.78 -6.48 -0.37 4.32e-10 Severe influenza A (H1N1) infection; CESC cis rs9527 0.590 rs12415199 chr10:104895536 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs6674176 0.932 rs12410334 chr1:44442521 A/C cg12908607 chr1:44402522 ARTN -0.43 -5.95 -0.34 8.45e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs8013055 0.846 rs8013827 chr14:105970176 C/T cg23356831 chr14:105996513 TMEM121 -0.36 -5.22 -0.31 3.64e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC cis rs10206020 0.842 rs7609325 chr2:1574718 G/A cg26248373 chr2:1572462 NA -0.59 -6.93 -0.39 3.22e-11 IgG glycosylation; CESC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg24250549 chr1:154909240 PMVK 0.74 11.08 0.56 1.06e-23 Prostate cancer; CESC cis rs7818345 1.000 rs6981898 chr8:19305705 A/G cg11303988 chr8:19266685 CSGALNACT1 0.34 6.18 0.35 2.45e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs17376456 0.877 rs9314093 chr5:93333347 G/A cg25358565 chr5:93447407 FAM172A 1.08 10.32 0.54 3.23e-21 Diabetic retinopathy; CESC cis rs11583043 1.000 rs34915449 chr1:101476786 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.53 5.84 0.34 1.54e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs1413885 0.549 rs9436726 chr1:65853196 T/C cg14976592 chr1:65886160 LEPROT;LEPR 0.48 6.32 0.36 1.13e-9 Anticoagulant levels; CESC cis rs7267979 0.932 rs2260997 chr20:25256266 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -15.46 -0.69 7.27e-39 Liver enzyme levels (alkaline phosphatase); CESC trans rs561341 1.000 rs1557731 chr17:30321567 T/G cg20587970 chr11:113659929 NA -1.13 -14.25 -0.66 1.39e-34 Hip circumference adjusted for BMI; CESC cis rs208520 0.874 rs208491 chr6:66928459 C/G cg07460842 chr6:66804631 NA -0.89 -10.73 -0.55 1.58e-22 Exhaled nitric oxide output; CESC cis rs11625487 0.505 rs10145609 chr14:77957377 G/A cg20045696 chr14:77926864 AHSA1 -0.44 -5.23 -0.31 3.42e-7 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg09177884 chr7:1199841 ZFAND2A -0.54 -5.95 -0.34 8.41e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03661428 chr13:111589040 NA -0.6 -6.35 -0.36 9.49e-10 Gut microbiome composition (summer); CESC cis rs10832963 0.686 rs11024743 chr11:18653712 A/G cg20219074 chr11:18656078 SPTY2D1 0.8 11.71 0.58 8.4e-26 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27613076 chr10:121484944 INPP5F -0.66 -7.93 -0.44 6.23e-14 Gut microbiome composition (summer); CESC cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg12923728 chr3:195709715 SDHAP1 -0.67 -8.99 -0.48 4.91e-17 Pancreatic cancer; CESC cis rs8016982 0.674 rs2288499 chr14:81660997 C/T cg01989461 chr14:81687754 GTF2A1 0.75 11.64 0.58 1.4e-25 Schizophrenia; CESC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg11494091 chr17:61959527 GH2 0.72 12.34 0.6 6.02e-28 Prudent dietary pattern; CESC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg01341218 chr17:43662625 NA -0.86 -10.6 -0.55 3.99e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9914988 0.887 rs11656272 chr17:27091153 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs2066819 1.000 rs2020854 chr12:56743367 T/C cg26714650 chr12:56694279 CS -1.22 -14.58 -0.67 9.61e-36 Psoriasis vulgaris; CESC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg14562523 chr21:43528734 C21orf128;UMODL1 -0.47 -7.31 -0.41 3.1e-12 IgG glycosylation; CESC cis rs6964587 1.000 rs1859037 chr7:91568272 A/G cg17063962 chr7:91808500 NA -0.59 -7.88 -0.44 8.67e-14 Breast cancer; CESC cis rs28386778 0.965 rs2854154 chr17:61981696 C/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.55 -6.89 -0.39 4.08e-11 Prudent dietary pattern; CESC cis rs10242455 0.702 rs79285548 chr7:99058396 T/C cg25640893 chr7:99214727 ZNF498 1.17 7.11 0.4 1.09e-11 Blood metabolite levels; CESC trans rs8135828 0.770 rs74395461 chr22:29933875 T/C cg17961835 chr3:126195582 ZXDC -0.45 -6.03 -0.35 5.35e-9 Lipid traits; CESC cis rs13256369 0.802 rs12541520 chr8:8564146 G/T cg18904891 chr8:8559673 CLDN23 0.69 8.09 0.45 2.13e-14 Obesity-related traits; CESC cis rs7274811 0.711 rs293713 chr20:31942247 A/G cg21523528 chr20:32077966 CBFA2T2 -0.47 -5.66 -0.33 3.84e-8 Height; CESC trans rs607987 0.836 rs1222202 chr11:30336613 G/A cg25993608 chr18:76621396 NA -0.42 -6.0 -0.35 6.63e-9 Body mass index; CESC cis rs11098499 0.863 rs6833334 chr4:120504227 C/T cg24375607 chr4:120327624 NA 0.46 5.47 0.32 1.05e-7 Corneal astigmatism; CESC cis rs1008375 1.000 rs4642241 chr4:17617111 T/C cg04450456 chr4:17643702 FAM184B 0.36 5.24 0.31 3.28e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6866344 0.697 rs62392832 chr5:178134395 T/C cg10224037 chr5:178157518 ZNF354A 0.6 6.75 0.38 9.05e-11 Neutrophil percentage of white cells; CESC cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg03433033 chr1:76189801 ACADM -0.67 -8.01 -0.44 3.56e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11098499 0.866 rs7665125 chr4:120402079 G/T cg09307838 chr4:120376055 NA 0.76 10.51 0.54 7.9e-22 Corneal astigmatism; CESC cis rs9487051 0.676 rs6913093 chr6:109636205 T/C cg21918786 chr6:109611834 NA -0.4 -5.8 -0.34 1.91e-8 Reticulocyte fraction of red cells; CESC cis rs36051895 0.623 rs11506668 chr9:5252789 C/T cg02405213 chr9:5042618 JAK2 -0.54 -6.37 -0.36 8.41e-10 Pediatric autoimmune diseases; CESC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg02038168 chr22:39784481 NA -0.58 -7.17 -0.4 7.65e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs868036 1.000 rs8037262 chr15:68108572 C/T cg08079166 chr15:68083412 MAP2K5 0.44 6.94 0.39 3e-11 Restless legs syndrome; CESC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Parkinson's disease; CESC cis rs240764 0.764 rs6903206 chr6:100929516 A/G cg21058520 chr6:100914733 NA -0.38 -5.94 -0.34 9.12e-9 Neuroticism; CESC cis rs7647973 0.769 rs6446204 chr3:49034879 T/C cg06212747 chr3:49208901 KLHDC8B 0.49 5.32 0.31 2.16e-7 Menarche (age at onset); CESC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg02018176 chr4:1364513 KIAA1530 0.41 5.91 0.34 1.04e-8 Longevity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22081084 chr1:89990230 LRRC8B 0.46 6.36 0.36 8.61e-10 Gut microbiota (bacterial taxa); CESC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg23161317 chr6:28129485 ZNF389 0.5 6.29 0.36 1.29e-9 Depression; CESC cis rs9916302 0.784 rs4795361 chr17:37573446 G/A cg00129232 chr17:37814104 STARD3 -0.59 -7.8 -0.43 1.45e-13 Glomerular filtration rate (creatinine); CESC cis rs1670533 1.000 rs13134921 chr4:1054177 A/G cg04106633 chr4:1044584 NA 0.42 5.34 0.31 2.04e-7 Recombination rate (females); CESC cis rs2072732 0.706 rs12564456 chr1:2936386 C/G cg15211996 chr1:2936768 ACTRT2 0.33 5.3 0.31 2.44e-7 Plateletcrit; CESC cis rs9640161 0.871 rs56156367 chr7:150047201 A/T cg10018233 chr7:150070692 REPIN1 0.36 5.2 0.3 3.99e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs7918232 0.882 rs788211 chr10:27479070 C/T cg14442939 chr10:27389572 ANKRD26 -0.63 -6.14 -0.35 2.95e-9 Breast cancer; CESC cis rs11690935 0.589 rs62183782 chr2:172865009 T/A cg13550731 chr2:172543902 DYNC1I2 0.5 6.81 0.39 6.42e-11 Schizophrenia; CESC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg24549020 chr5:56110836 MAP3K1 0.64 7.46 0.42 1.26e-12 Initial pursuit acceleration; CESC cis rs4595586 0.655 rs11831499 chr12:39310114 A/T cg26384229 chr12:38710491 ALG10B 0.42 6.11 0.35 3.51e-9 Morning vs. evening chronotype; CESC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg24531977 chr5:56204891 C5orf35 -0.46 -5.67 -0.33 3.72e-8 Coronary artery disease; CESC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs1814175 0.566 rs1811673 chr11:49602134 A/G cg15704280 chr7:45808275 SEPT13 -0.88 -10.8 -0.55 8.69e-23 Height; CESC cis rs73110464 0.609 rs11170348 chr12:53355588 A/G cg14581129 chr12:53358946 NA -0.57 -7.69 -0.43 2.84e-13 Cancer (pleiotropy); CESC cis rs11626933 0.959 rs2149649 chr14:90774974 A/G cg14092571 chr14:90743983 NA 0.91 15.01 0.68 2.86e-37 Gut microbiota (bacterial taxa); CESC cis rs941408 0.515 rs4624312 chr19:2774460 T/C cg02580895 chr19:2754563 NA -0.46 -6.02 -0.35 5.71e-9 Total cholesterol levels; CESC cis rs3796352 1.000 rs11707780 chr3:53084326 A/G cg07884673 chr3:53033167 SFMBT1 -0.59 -6.04 -0.35 5.05e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs554111 0.560 rs592060 chr1:21050958 A/G cg08890418 chr1:21044141 KIF17 -0.49 -6.23 -0.36 1.82e-9 Facial morphology (factor 17, height of vermillion upper lip); CESC cis rs2901656 0.640 rs4916258 chr1:172413526 T/G cg03748243 chr1:172413542 C1orf105;PIGC 0.54 8.28 0.45 5.98e-15 Red cell distribution width;Platelet distribution width; CESC cis rs11822910 1.000 rs2439448 chr11:57199211 T/C cg00522883 chr11:57194120 SLC43A3 0.57 6.65 0.38 1.63e-10 Platelet distribution width; CESC cis rs36051895 0.623 rs12351715 chr9:5262349 A/G cg02405213 chr9:5042618 JAK2 -0.49 -6.01 -0.35 6.2e-9 Pediatric autoimmune diseases; CESC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg08859206 chr1:53392774 SCP2 0.54 7.13 0.4 9.6e-12 Monocyte count; CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg07424592 chr7:64974309 NA -0.35 -5.09 -0.3 6.74e-7 Calcium levels; CESC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.26 0.36 1.51e-9 Cystic fibrosis severity; CESC cis rs6963495 0.818 rs73190181 chr7:105162907 A/C cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs1707322 0.963 rs6690652 chr1:46376692 G/T cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.51 5.07 0.3 7.6e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg18402987 chr7:1209562 NA 0.76 7.55 0.42 7.26e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8114671 0.836 rs6060140 chr20:33566507 G/A cg06115741 chr20:33292138 TP53INP2 0.46 5.54 0.32 7.42e-8 Height; CESC cis rs897984 0.609 rs35468353 chr16:31056433 A/G cg02466173 chr16:30829666 NA -0.39 -6.77 -0.38 8.15e-11 Dementia with Lewy bodies; CESC cis rs34779708 0.931 rs7079205 chr10:35324619 C/T cg04310649 chr10:35416472 CREM -0.49 -5.7 -0.33 3.24e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg05863683 chr7:1912471 MAD1L1 0.44 6.67 0.38 1.5e-10 Autism spectrum disorder or schizophrenia; CESC trans rs61931739 0.534 rs2389276 chr12:34097891 T/C cg26384229 chr12:38710491 ALG10B 0.52 7.07 0.4 1.35e-11 Morning vs. evening chronotype; CESC cis rs4423214 0.918 rs11233789 chr11:71181085 A/G cg24826892 chr11:71159390 DHCR7 0.45 5.14 0.3 5.42e-7 Vitamin D levels; CESC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg18190219 chr22:46762943 CELSR1 -0.56 -6.37 -0.36 8.5e-10 LDL cholesterol;Cholesterol, total; CESC cis rs11792861 0.926 rs17729523 chr9:111773317 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.46 5.69 0.33 3.29e-8 Menarche (age at onset); CESC cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg03060546 chr3:49711283 APEH 0.64 7.34 0.41 2.55e-12 Menarche (age at onset); CESC cis rs9303401 0.646 rs9892425 chr17:57241938 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.49 6.47 0.37 4.83e-10 Cognitive test performance; CESC cis rs10089 0.953 rs1432614 chr5:127416919 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 9.86 0.52 9.37e-20 Ileal carcinoids; CESC cis rs2243480 1.000 rs1873494 chr7:65649899 T/C cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.24e-32 Diabetic kidney disease; CESC cis rs6831352 0.918 rs13112176 chr4:100055825 G/A cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.56 0.37 2.87e-10 Life satisfaction; CESC cis rs11690935 0.959 rs7562356 chr2:172626611 C/G cg13550731 chr2:172543902 DYNC1I2 -1.01 -16.63 -0.71 5.07e-43 Schizophrenia; CESC cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg00825309 chr19:58991885 ZNF446 -0.58 -8.22 -0.45 8.94e-15 Uric acid clearance; CESC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg22920501 chr2:26401640 FAM59B -0.66 -7.89 -0.44 8.09e-14 Gut microbiome composition (summer); CESC cis rs854765 0.647 rs6826 chr17:18011140 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.4 0.46 2.71e-15 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13769605 chr2:12857067 TRIB2 -0.55 -6.4 -0.37 6.97e-10 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.29e-8 Developmental language disorder (linguistic errors); CESC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg06060754 chr5:176797920 RGS14 -0.48 -5.14 -0.3 5.22e-7 Hemoglobin concentration;Hematocrit; CESC trans rs7945404 0.548 rs4936618 chr11:121223996 G/T cg09432902 chr12:113909932 LHX5 -0.39 -6.08 -0.35 4.07e-9 QT interval; CESC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg11890956 chr21:40555474 PSMG1 -0.95 -15.1 -0.68 1.38e-37 Cognitive function; CESC cis rs3008870 1.000 rs2985821 chr1:67403787 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7524258 0.903 rs4908608 chr1:7292772 T/C cg07173049 chr1:7289937 CAMTA1 0.47 7.14 0.4 9e-12 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs11792861 0.591 rs7044275 chr9:111717138 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.62 9.55 0.51 9.13e-19 Menarche (age at onset); CESC cis rs1801251 0.929 rs10933409 chr2:233629386 A/G cg25237894 chr2:233734115 C2orf82 0.45 7.9 0.44 7.6e-14 Coronary artery disease; CESC cis rs6831352 1.000 rs1126670 chr4:100052733 C/A cg21548116 chr4:100009993 ADH5 0.48 5.15 0.3 4.98e-7 Alcohol dependence; CESC cis rs3106136 0.967 rs767657 chr4:95227901 G/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.59 -0.38 2.41e-10 Capecitabine sensitivity; CESC cis rs453301 0.538 rs7830804 chr8:8970762 G/T cg06636001 chr8:8085503 FLJ10661 -0.45 -5.66 -0.33 3.95e-8 Joint mobility (Beighton score); CESC cis rs9811920 0.516 rs793486 chr3:99493165 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.33 -5.44 -0.32 1.2e-7 Axial length; CESC cis rs9487051 0.676 rs6913093 chr6:109636205 T/C cg12927641 chr6:109611667 NA -0.4 -5.84 -0.34 1.49e-8 Reticulocyte fraction of red cells; CESC cis rs858239 0.539 rs2390757 chr7:23191492 A/G cg23682824 chr7:23144976 KLHL7 0.42 5.23 0.31 3.38e-7 Cerebrospinal fluid biomarker levels; CESC cis rs10949834 0.877 rs34325097 chr7:73492990 G/A cg07137043 chr7:73588983 EIF4H -0.64 -5.43 -0.32 1.28e-7 Verbal memory performance (residualized delayed recall change); CESC cis rs2016266 0.859 rs10747668 chr12:53737461 C/T cg26875137 chr12:53738046 NA 0.35 5.28 0.31 2.66e-7 Bone mineral density (spine);Bone mineral density; CESC cis rs453301 0.624 rs6987558 chr8:8862521 C/G cg15556689 chr8:8085844 FLJ10661 0.45 5.77 0.33 2.18e-8 Joint mobility (Beighton score); CESC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg09658497 chr7:2847517 GNA12 -0.44 -6.32 -0.36 1.13e-9 Height; CESC cis rs7937682 0.562 rs519850 chr11:111376888 A/T cg22437258 chr11:111473054 SIK2 0.45 5.63 0.33 4.59e-8 Primary sclerosing cholangitis; CESC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.54 7.4 0.41 1.83e-12 Lymphocyte counts; CESC cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg01475377 chr6:109611718 NA -0.45 -7.11 -0.4 1.08e-11 Reticulocyte fraction of red cells; CESC cis rs11072805 1 rs11072805 chr15:79078518 T/C cg04896959 chr15:78267971 NA 0.34 5.11 0.3 6.16e-7 Post bronchodilator FEV1/FVC ratio; CESC trans rs7944735 0.671 rs1228044 chr11:48011180 A/G cg07554734 chr6:7728676 BMP6 -0.36 -6.24 -0.36 1.76e-9 Intraocular pressure; CESC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg22920501 chr2:26401640 FAM59B 0.93 10.89 0.56 4.54e-23 Gut microbiome composition (summer); CESC cis rs12079745 0.793 rs12071224 chr1:169191945 C/T cg09363564 chr1:169337483 NME7;BLZF1 -1.01 -6.29 -0.36 1.34e-9 QT interval; CESC cis rs7582720 0.943 rs72928610 chr2:203838961 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg05564831 chr3:52568323 NT5DC2 0.42 6.13 0.35 3.1e-9 Bipolar disorder; CESC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 12.96 0.62 4.51e-30 Platelet count; CESC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg04267008 chr7:1944627 MAD1L1 0.72 9.66 0.51 4.02e-19 Bipolar disorder and schizophrenia; CESC cis rs1707322 1.000 rs6671754 chr1:46433990 A/G cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1801251 0.685 rs1515961 chr2:233623763 C/A cg25237894 chr2:233734115 C2orf82 0.35 6.01 0.35 6.01e-9 Coronary artery disease; CESC cis rs1707322 0.685 rs11211177 chr1:46226349 A/G cg03146154 chr1:46216737 IPP 0.77 11.13 0.56 7.46e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs10510776 0.875 rs11710973 chr3:55217512 C/T cg24055398 chr17:73127994 NT5C 0.58 6.17 0.35 2.59e-9 Cancer; CESC cis rs7560272 0.723 rs1320374 chr2:73828310 T/C cg20560298 chr2:73613845 ALMS1 0.5 7.06 0.4 1.5e-11 Schizophrenia; CESC cis rs7524258 0.868 rs4243825 chr1:7308264 T/C cg07173049 chr1:7289937 CAMTA1 0.42 6.29 0.36 1.3e-9 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg17971929 chr21:40555470 PSMG1 -0.54 -7.04 -0.4 1.6e-11 Menarche (age at onset); CESC cis rs854765 0.583 rs8073001 chr17:17831716 A/C cg16928487 chr17:17741425 SREBF1 0.56 9.79 0.52 1.66e-19 Total body bone mineral density; CESC cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.7 0.33 3.17e-8 Tonsillectomy; CESC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg14703610 chr5:56206110 C5orf35 -0.44 -5.78 -0.33 2.07e-8 Coronary artery disease; CESC cis rs17376456 0.877 rs10476596 chr5:93367074 C/T cg21475434 chr5:93447410 FAM172A -0.79 -6.72 -0.38 1.08e-10 Diabetic retinopathy; CESC cis rs34779708 0.966 rs12775759 chr10:35400183 G/T cg04310649 chr10:35416472 CREM -0.52 -6.25 -0.36 1.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.92e-7 Lung cancer; CESC cis rs950776 0.518 rs4886572 chr15:78837452 A/G cg06917634 chr15:78832804 PSMA4 -0.76 -11.61 -0.58 1.83e-25 Sudden cardiac arrest; CESC cis rs8023845 1.000 rs62019997 chr15:40443476 T/C cg20259534 chr15:40453036 BUB1B 0.68 6.76 0.38 8.58e-11 Chronic lymphocytic leukemia; CESC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs977987 0.806 rs7202596 chr16:75491072 G/T cg03315344 chr16:75512273 CHST6 0.44 6.31 0.36 1.15e-9 Dupuytren's disease; CESC cis rs863345 1.000 rs863356 chr1:158543739 G/T cg12129480 chr1:158549410 OR10X1 -0.32 -6.49 -0.37 4.31e-10 Pneumococcal bacteremia; CESC cis rs7551222 0.752 rs10900594 chr1:204470129 C/G cg20240347 chr1:204465584 NA -0.25 -5.09 -0.3 6.89e-7 Schizophrenia; CESC cis rs4130590 0.966 rs6478770 chr9:130112231 T/C cg13736810 chr9:130213283 LRSAM1;RPL12 0.51 6.08 0.35 4.28e-9 Bipolar disorder; CESC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg08923669 chr16:420230 MRPL28 -0.47 -6.2 -0.36 2.1e-9 Bone mineral density (spine);Bone mineral density; CESC trans rs61931739 0.500 rs7963282 chr12:34535255 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 8.03e-13 Morning vs. evening chronotype; CESC trans rs561341 0.941 rs2428338 chr17:30299629 T/C cg20587970 chr11:113659929 NA -1.14 -14.35 -0.66 6.11e-35 Hip circumference adjusted for BMI; CESC trans rs7173947 0.646 rs11634297 chr15:95267564 A/T cg09233161 chr9:37079712 NA -0.46 -6.42 -0.37 6.4e-10 Hematological and biochemical traits; CESC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg00310523 chr12:86230176 RASSF9 0.37 5.57 0.32 6.15e-8 Major depressive disorder; CESC cis rs7119 0.717 rs11636412 chr15:77767291 C/T cg17802220 chr15:77601643 NA -0.51 -7.18 -0.4 7.24e-12 Type 2 diabetes; CESC cis rs4948102 0.767 rs4948096 chr7:56053118 C/T cg09872392 chr7:56161020 PHKG1 -0.46 -7.25 -0.41 4.59e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs2281558 0.833 rs6115202 chr20:25497538 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.55 -7.76 -0.43 1.9e-13 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs9858542 1.000 rs34762726 chr3:49689210 G/A cg03060546 chr3:49711283 APEH -0.59 -6.94 -0.39 2.96e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg05340658 chr4:99064831 C4orf37 0.79 12.27 0.6 1.02e-27 Colonoscopy-negative controls vs population controls; CESC cis rs6539267 0.748 rs1921953 chr12:106721012 C/T cg02476566 chr12:106696527 TCP11L2 0.44 5.2 0.3 4.06e-7 Tourette syndrome; CESC cis rs17376456 0.877 rs7701974 chr5:93311417 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.33 0.31 2.15e-7 Diabetic retinopathy; CESC cis rs9399135 1.000 rs9399135 chr6:135368314 G/A cg22676075 chr6:135203613 NA 0.48 6.71 0.38 1.2e-10 Red blood cell count; CESC cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg03433033 chr1:76189801 ACADM -0.62 -6.54 -0.37 3.12e-10 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14089512 chr10:102106757 SCD 0.61 7.37 0.41 2.13e-12 Gut microbiome composition (summer); CESC cis rs57221529 0.766 rs12519763 chr5:559145 C/T cg09021430 chr5:549028 NA -0.42 -5.26 -0.31 2.92e-7 Lung disease severity in cystic fibrosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00028918 chr5:159200479 NA 0.48 6.11 0.35 3.47e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg11644478 chr21:40555479 PSMG1 1.03 16.3 0.71 7.81e-42 Cognitive function; CESC cis rs3091242 0.933 rs3093584 chr1:25668714 T/C cg12412775 chr1:25698385 RHCE 0.32 5.68 0.33 3.54e-8 Erythrocyte sedimentation rate; CESC cis rs13315871 0.929 rs73835170 chr3:58318448 A/G cg20936604 chr3:58311152 NA -0.51 -5.13 -0.3 5.57e-7 Cholesterol, total; CESC cis rs155076 0.625 rs4769159 chr13:21881978 A/C cg11317459 chr13:21872234 NA 1.2 15.33 0.69 2.11e-38 White matter hyperintensity burden; CESC cis rs6493487 0.512 rs7165920 chr15:51229808 G/A cg02338191 chr15:51200825 AP4E1 0.61 5.56 0.32 6.72e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7818345 0.967 rs12679671 chr8:19270831 G/T cg11303988 chr8:19266685 CSGALNACT1 0.33 5.96 0.34 7.84e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs9325144 0.650 rs6582624 chr12:38733475 A/T cg26384229 chr12:38710491 ALG10B -0.55 -7.59 -0.42 5.47e-13 Morning vs. evening chronotype; CESC cis rs57024841 0.500 rs6560652 chr9:139830940 C/T cg00693599 chr9:139836323 FBXW5 -0.42 -6.11 -0.35 3.46e-9 Beta-trace protein levels; CESC cis rs1707322 0.691 rs28495425 chr1:46187320 T/G cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs763121 0.853 rs5757253 chr22:39104320 C/T cg06022373 chr22:39101656 GTPBP1 0.95 18.07 0.74 3.97e-48 Menopause (age at onset); CESC cis rs7552404 0.545 rs12748741 chr1:76351193 A/G cg22875332 chr1:76189707 ACADM -0.56 -5.75 -0.33 2.44e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9916302 0.904 rs11078898 chr17:37536480 A/G cg15445000 chr17:37608096 MED1 -0.4 -6.54 -0.37 3.24e-10 Glomerular filtration rate (creatinine); CESC cis rs12042052 1.000 rs6686747 chr1:232912743 T/C cg06935979 chr1:232941706 KIAA1383 0.64 6.16 0.35 2.69e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg03467027 chr4:99064603 C4orf37 0.48 6.15 0.35 2.83e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs9916302 0.904 rs4795357 chr17:37569551 T/C cg20243544 chr17:37824526 PNMT 0.49 5.92 0.34 9.98e-9 Glomerular filtration rate (creatinine); CESC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.61 7.58 0.42 5.93e-13 Height; CESC cis rs9399135 0.933 rs4559100 chr6:135324085 T/C cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg24531977 chr5:56204891 C5orf35 -0.89 -11.26 -0.57 2.62e-24 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01124529 chr16:87743286 KLHDC4 -0.53 -6.63 -0.38 1.89e-10 Gut microbiome composition (summer); CESC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg07507251 chr3:52567010 NT5DC2 0.44 7.38 0.41 2.11e-12 Bipolar disorder; CESC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg22903657 chr4:1355424 KIAA1530 -0.38 -5.23 -0.31 3.48e-7 Obesity-related traits; CESC cis rs10924970 0.687 rs10802441 chr1:235357698 A/T cg26050004 chr1:235667680 B3GALNT2 0.44 5.09 0.3 6.95e-7 Asthma; CESC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg07507251 chr3:52567010 NT5DC2 0.45 8.38 0.46 3.04e-15 Electroencephalogram traits; CESC cis rs1580019 0.522 rs10951340 chr7:32562408 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.07 19.04 0.76 1.57e-51 Cognitive ability; CESC cis rs10779751 0.734 rs2261317 chr1:11124979 A/G cg08854313 chr1:11322531 MTOR 0.77 10.41 0.54 1.73e-21 Body mass index; CESC cis rs1045902 0.574 rs1053329 chr2:73461483 C/A cg01422370 chr2:73384389 NA 0.39 5.31 0.31 2.36e-7 Intelligence (multi-trait analysis); CESC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Urate levels; CESC cis rs6580649 0.943 rs1990029 chr12:48407987 C/T cg24011408 chr12:48396354 COL2A1 0.44 5.44 0.32 1.18e-7 Lung cancer; CESC trans rs9929218 0.551 rs7201437 chr16:68727130 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.9 14.8 0.67 1.6e-36 Colorectal cancer; CESC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg07414643 chr4:187882934 NA -0.52 -7.28 -0.41 3.88e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs11725477 chr4:98803266 G/T cg05340658 chr4:99064831 C4orf37 0.75 11.11 0.56 8.68e-24 Colonoscopy-negative controls vs population controls; CESC cis rs10979 1.000 rs13211390 chr6:143888010 A/T cg25407410 chr6:143891975 LOC285740 -0.63 -9.51 -0.5 1.24e-18 Hypospadias; CESC cis rs6815814 0.731 rs66735315 chr4:38774180 G/T cg02016764 chr4:38805732 TLR1 -0.44 -6.08 -0.35 4.24e-9 Breast cancer; CESC cis rs11122272 0.735 rs2491407 chr1:231518928 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC trans rs3934047 0.904 rs4448893 chr15:82011355 T/C cg07747791 chr7:27498134 NA -0.4 -6.31 -0.36 1.19e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs1707322 0.752 rs11488313 chr1:46224780 G/C cg03146154 chr1:46216737 IPP 0.8 11.44 0.57 6.8e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12229918 0.540 rs10784460 chr12:65863584 C/T cg09854775 chr9:137029881 RNU6ATAC 0.52 6.32 0.36 1.11e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CESC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.95 -15.11 -0.68 1.21e-37 Prudent dietary pattern; CESC cis rs11048434 0.736 rs34798934 chr12:9108444 C/T cg23795048 chr12:9217529 LOC144571 0.35 5.31 0.31 2.28e-7 Sjögren's syndrome; CESC cis rs9300255 0.602 rs1716164 chr12:123663660 G/A cg00376283 chr12:123451042 ABCB9 0.71 8.92 0.48 7.69e-17 Neutrophil percentage of white cells; CESC cis rs3806843 0.933 rs2879087 chr5:140188575 G/C cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.11 -0.3 6.12e-7 Depressive symptoms (multi-trait analysis); CESC cis rs477692 0.685 rs551491 chr10:131397821 G/A cg05714579 chr10:131428358 MGMT 0.5 6.88 0.39 4.21e-11 Response to temozolomide; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg11383747 chr17:260000 C17orf97 -0.54 -7.27 -0.41 4.03e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs1814175 0.619 rs847644 chr11:49918418 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs2204008 0.777 rs8189597 chr12:38307739 G/C cg26384229 chr12:38710491 ALG10B -0.73 -10.64 -0.55 2.97e-22 Bladder cancer; CESC cis rs10751667 0.666 rs7936830 chr11:959686 A/G cg20946044 chr11:1010712 AP2A2 -0.38 -5.28 -0.31 2.65e-7 Alzheimer's disease (late onset); CESC cis rs16854884 0.710 rs6782558 chr3:143817462 G/C cg06585982 chr3:143692056 C3orf58 0.46 6.11 0.35 3.6e-9 Economic and political preferences (feminism/equality); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07023867 chr18:55710965 NEDD4L 0.59 6.56 0.37 2.89e-10 Gut microbiome composition (summer); CESC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg23283495 chr1:209979779 IRF6 0.53 6.26 0.36 1.56e-9 Cleft lip with or without cleft palate; CESC cis rs796364 0.806 rs112305133 chr2:201010380 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -6.43 -0.37 5.87e-10 Schizophrenia; CESC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg07507251 chr3:52567010 NT5DC2 0.43 7.4 0.41 1.84e-12 Bipolar disorder; CESC cis rs6032067 0.704 rs2223901 chr20:43789924 C/G cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19374457 chr1:44412380 IPO13 0.57 6.74 0.38 9.79e-11 Gut microbiome composition (summer); CESC cis rs1728785 1.000 rs1624718 chr16:68580385 A/G cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs3820928 0.874 rs13393894 chr2:227880543 A/G cg05526886 chr2:227700861 RHBDD1 -0.43 -5.48 -0.32 9.75e-8 Pulmonary function; CESC cis rs4919087 0.748 rs701810 chr10:98974849 C/T cg25902810 chr10:99078978 FRAT1 -0.45 -5.2 -0.3 3.96e-7 Monocyte count; CESC cis rs6912958 0.781 rs7742965 chr6:88278196 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.58 -0.37 2.55e-10 Monocyte percentage of white cells; CESC cis rs30380 0.632 rs30186 chr5:96124447 G/C cg16492584 chr5:96139282 ERAP1 -0.47 -6.63 -0.38 1.89e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7246657 0.943 rs13343502 chr19:37962292 C/T cg23950597 chr19:37808831 NA -0.61 -6.23 -0.36 1.85e-9 Coronary artery calcification; CESC cis rs55788414 0.505 rs7190543 chr16:81189320 T/C cg06400318 chr16:81190750 PKD1L2 -0.51 -6.68 -0.38 1.38e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9303401 0.659 rs35797125 chr17:56736547 G/A cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.13 0.63 1.12e-30 Cognitive test performance; CESC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg14893161 chr1:205819251 PM20D1 0.87 15.37 0.69 1.47e-38 Menarche (age at onset); CESC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg18225595 chr11:63971243 STIP1 0.52 5.13 0.3 5.55e-7 Mean platelet volume; CESC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.08 -20.03 -0.78 5.86e-55 Prudent dietary pattern; CESC cis rs3780486 0.846 rs7036812 chr9:33143822 T/C cg13443165 chr9:33130375 B4GALT1 0.48 7.09 0.4 1.21e-11 IgG glycosylation; CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg23281280 chr6:28129359 ZNF389 0.6 8.42 0.46 2.34e-15 Depression; CESC cis rs7659604 0.540 rs10007956 chr4:122700669 A/T cg19671926 chr4:122722719 EXOSC9 0.66 8.86 0.48 1.22e-16 Type 2 diabetes; CESC cis rs6466055 0.501 rs6965384 chr7:104603112 A/G cg04380332 chr7:105027541 SRPK2 -0.38 -5.5 -0.32 8.8e-8 Schizophrenia; CESC cis rs28374715 1.000 rs28374715 chr15:41563950 A/G cg18705301 chr15:41695430 NDUFAF1 -0.83 -11.24 -0.57 3.04e-24 Ulcerative colitis; CESC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs4843747 0.749 rs72818535 chr16:88074039 G/A cg06915872 chr16:87998081 BANP 0.49 5.91 0.34 1.04e-8 Menopause (age at onset); CESC cis rs9611519 0.602 rs8138520 chr22:41412928 A/G cg03806693 chr22:41940476 POLR3H -0.51 -6.04 -0.35 5.18e-9 Neuroticism; CESC cis rs10733682 0.633 rs869500 chr9:129465898 G/A cg00232160 chr9:129468157 NA 0.38 6.07 0.35 4.47e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7635838 0.503 rs9853547 chr3:11396101 C/G cg00170343 chr3:11313890 ATG7 0.47 6.56 0.37 2.77e-10 HDL cholesterol; CESC cis rs9486719 1.000 rs4078038 chr6:96904366 A/G cg18709589 chr6:96969512 KIAA0776 -0.53 -5.8 -0.34 1.92e-8 Migraine;Coronary artery disease; CESC cis rs9911578 1.000 rs11869828 chr17:56609525 G/A cg12560992 chr17:57184187 TRIM37 -0.93 -15.59 -0.69 2.43e-39 Intelligence (multi-trait analysis); CESC cis rs9916302 0.904 rs8079303 chr17:37530755 G/C cg20243544 chr17:37824526 PNMT -0.49 -6.14 -0.35 3.08e-9 Glomerular filtration rate (creatinine); CESC cis rs9487051 0.714 rs6903695 chr6:109631422 C/G cg01475377 chr6:109611718 NA 0.44 6.97 0.39 2.45e-11 Reticulocyte fraction of red cells; CESC cis rs7927592 0.763 rs11822059 chr11:68300822 T/G cg16797656 chr11:68205561 LRP5 0.47 7.1 0.4 1.15e-11 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12680424 chr13:19239716 NA -0.56 -6.56 -0.37 2.87e-10 Gut microbiome composition (summer); CESC cis rs2412488 0.893 rs6840530 chr4:54359726 C/T cg22241045 chr4:54363911 LNX1 -0.39 -5.33 -0.31 2.09e-7 DNA methylation (variation); CESC cis rs734999 0.588 rs60520190 chr1:2533706 G/A cg20673091 chr1:2541236 MMEL1 0.44 7.36 0.41 2.28e-12 Ulcerative colitis; CESC cis rs8017423 0.967 rs11621431 chr14:90709221 C/T cg14092571 chr14:90743983 NA -0.57 -8.44 -0.46 2.09e-15 Mortality in heart failure; CESC cis rs826838 0.967 rs11183577 chr12:38781887 A/G cg13010199 chr12:38710504 ALG10B 0.6 8.55 0.46 1.02e-15 Heart rate; CESC trans rs1814175 0.645 rs1721995 chr11:49915488 A/G cg11707556 chr5:10655725 ANKRD33B -0.42 -6.25 -0.36 1.68e-9 Height; CESC cis rs782590 0.774 rs2627773 chr2:55900459 A/G cg18811423 chr2:55921094 PNPT1 0.79 12.77 0.62 2.02e-29 Metabolic syndrome; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13083637 chr1:169337225 BLZF1;NME7 -0.44 -6.38 -0.36 7.94e-10 Gambling; CESC cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg11890956 chr21:40555474 PSMG1 1.15 20.17 0.78 1.84e-55 Cognitive function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17043284 chr1:32228579 BAI2 0.47 6.06 0.35 4.68e-9 Gut microbiota (bacterial taxa); CESC cis rs861020 0.630 rs599649 chr1:210003402 T/C cg05527609 chr1:210001259 C1orf107 0.75 9.82 0.52 1.25e-19 Orofacial clefts; CESC cis rs3096299 0.967 rs2911253 chr16:89488587 T/G cg02187348 chr16:89574699 SPG7 0.58 7.9 0.44 7.55e-14 Multiple myeloma (IgH translocation); CESC cis rs17125944 0.505 rs118053951 chr14:53259829 G/A cg13660082 chr14:53194042 PSMC6 -0.65 -5.74 -0.33 2.53e-8 Alzheimer's disease (late onset); CESC cis rs11229555 1.000 rs7102510 chr11:58371283 T/G cg15696309 chr11:58395628 NA -0.43 -5.64 -0.33 4.3e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs4722166 0.630 rs2091115 chr7:22810166 G/T cg05265849 chr7:22767390 IL6 0.49 6.33 0.36 1.03e-9 Lung cancer; CESC cis rs4727027 0.933 rs1468369 chr7:148839840 G/C cg23583168 chr7:148888333 NA -0.73 -10.82 -0.55 7.76e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg20887711 chr4:1340912 KIAA1530 0.85 11.49 0.58 4.64e-25 Longevity; CESC cis rs6460942 0.915 rs62448600 chr7:12454944 T/G cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs9488822 0.636 rs12201275 chr6:116314563 C/G cg18764771 chr6:116381957 FRK 0.22 5.34 0.31 1.95e-7 Cholesterol, total;LDL cholesterol; CESC cis rs4481887 0.800 rs4514268 chr1:248444600 T/G cg00666640 chr1:248458726 OR2T12 0.36 6.19 0.36 2.27e-9 Common traits (Other); CESC cis rs11976180 0.517 rs6949375 chr7:143773851 T/G cg10157972 chr7:143270135 LOC441294 -0.39 -5.34 -0.31 1.97e-7 Obesity-related traits; CESC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg07677032 chr17:61819896 STRADA 0.41 5.28 0.31 2.64e-7 Height; CESC cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg05347473 chr6:146136440 FBXO30 0.59 7.82 0.43 1.24e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs9926296 0.712 rs258330 chr16:89729574 T/G cg04287289 chr16:89883240 FANCA -0.44 -5.6 -0.33 5.3e-8 Vitiligo; CESC cis rs7552167 0.925 rs3932664 chr1:24511663 G/T cg01960748 chr1:24522592 NA -0.42 -5.51 -0.32 8.54e-8 Psoriasis vulgaris; CESC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.38 -6.62 -0.38 1.94e-10 Bipolar disorder; CESC trans rs2018683 0.624 rs1006521 chr7:28996220 G/A cg19402173 chr7:128379420 CALU -0.58 -7.01 -0.4 1.98e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs10392 0.543 rs56660421 chr20:37559329 G/T cg27552599 chr20:37590471 DHX35 0.38 5.72 0.33 2.82e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs1775715 0.705 rs2778651 chr10:32106575 C/T cg18675610 chr10:32216311 ARHGAP12 0.33 5.1 0.3 6.52e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs2859741 0.608 rs480411 chr1:37476077 T/C cg09363841 chr1:37513479 NA -0.51 -7.2 -0.4 6.25e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs2380220 0.606 rs7747776 chr6:96005852 C/T cg23517279 chr6:96025343 MANEA 0.49 5.55 0.32 7e-8 Behavioural disinhibition (generation interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14950044 chr20:49457327 BCAS4 -0.66 -7.61 -0.42 4.86e-13 Gut microbiome composition (summer); CESC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg17949981 chr6:28129498 ZNF389 0.42 5.24 0.31 3.27e-7 Parkinson's disease; CESC cis rs10242455 0.867 rs2687081 chr7:99300758 G/A cg07715041 chr7:99302981 CYP3A7 -0.44 -5.56 -0.32 6.73e-8 Blood metabolite levels; CESC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg18190219 chr22:46762943 CELSR1 -0.58 -6.66 -0.38 1.6e-10 LDL cholesterol;Cholesterol, total; CESC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg06634786 chr22:41940651 POLR3H 0.68 6.78 0.38 7.6e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs790123 1.000 rs790117 chr3:122380888 C/T cg17380795 chr3:122379686 NA 0.35 5.3 0.31 2.47e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs7188697 0.883 rs4485352 chr16:58601410 A/G cg02549819 chr16:58548995 SETD6 0.44 5.43 0.32 1.26e-7 QT interval; CESC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.28 -0.31 2.74e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.46 0.42 1.21e-12 Prudent dietary pattern; CESC cis rs11098499 0.604 rs2389887 chr4:120570644 T/C cg24375607 chr4:120327624 NA 0.44 5.35 0.31 1.87e-7 Corneal astigmatism; CESC cis rs863345 0.967 rs4620544 chr1:158470747 C/T cg12129480 chr1:158549410 OR10X1 -0.31 -6.14 -0.35 3.08e-9 Pneumococcal bacteremia; CESC cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg24110177 chr3:50126178 RBM5 -0.54 -7.23 -0.41 5.19e-12 Intelligence (multi-trait analysis); CESC cis rs6964587 0.839 rs17731846 chr7:91440342 A/G cg01689657 chr7:91764605 CYP51A1 0.28 5.03 0.3 8.96e-7 Breast cancer; CESC cis rs60871478 1.000 rs62432242 chr7:797715 G/A cg27478167 chr7:817139 HEATR2 -0.51 -6.0 -0.35 6.34e-9 Cerebrospinal P-tau181p levels; CESC cis rs4563143 0.675 rs17498203 chr19:29279734 G/T cg12756686 chr19:29218302 NA 0.58 7.36 0.41 2.38e-12 Methadone dose in opioid dependence; CESC cis rs59901009 0.569 rs12280005 chr11:10228452 G/A cg01453529 chr11:10209919 SBF2 -0.46 -5.67 -0.33 3.77e-8 Hematocrit;Hemoglobin concentration; CESC trans rs1223629 1.000 rs55909847 chr10:95941476 A/G cg16346422 chr11:2920819 SLC22A18;SLC22A18AS 0.67 6.04 0.35 5.08e-9 Glucose homeostasis traits; CESC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg00339695 chr16:24857497 SLC5A11 -0.5 -6.58 -0.37 2.49e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4566357 1.000 rs2177598 chr2:227922900 T/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.28 -0.31 2.76e-7 Coronary artery disease; CESC cis rs2439831 0.850 rs3862142 chr15:44064806 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.7 6.79 0.38 7.39e-11 Lung cancer in ever smokers; CESC cis rs9287719 0.839 rs12692415 chr2:10745474 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20306180 chr22:32340197 C22orf24;YWHAH -0.47 -6.77 -0.38 8.07e-11 Gut microbiota (bacterial taxa); CESC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg00129232 chr17:37814104 STARD3 -0.53 -6.8 -0.39 7.03e-11 Glomerular filtration rate (creatinine); CESC cis rs2108622 1.000 rs55744319 chr19:15981821 G/A cg13772218 chr19:15982569 NA 0.38 7.14 0.4 8.98e-12 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs709400 1.000 rs3783404 chr14:104118498 A/G cg24130564 chr14:104152367 KLC1 -0.42 -5.41 -0.32 1.44e-7 Body mass index; CESC cis rs62103177 0.810 rs62103187 chr18:77627633 G/C cg12964065 chr18:77638022 KCNG2 0.58 5.46 0.32 1.07e-7 Opioid sensitivity; CESC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs2074585 0.517 rs11637971 chr15:91079863 A/C cg22089800 chr15:90895588 ZNF774 -0.43 -5.15 -0.3 5e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.27 0.31 2.85e-7 Bipolar disorder; CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -5.26 -0.31 2.94e-7 Bipolar disorder; CESC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg07157834 chr1:205819609 PM20D1 0.69 10.26 0.53 5.29e-21 Menarche (age at onset); CESC cis rs11098499 0.554 rs2175381 chr4:120265967 T/C cg09307838 chr4:120376055 NA 0.75 9.66 0.51 4.11e-19 Corneal astigmatism; CESC cis rs12216125 0.554 rs6942196 chr6:26072804 A/G cg17691542 chr6:26056736 HIST1H1C 0.42 5.66 0.33 3.97e-8 Iron status biomarkers; CESC cis rs4243830 0.850 rs12744992 chr1:6601290 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.99 -9.98 -0.52 4.03e-20 Body mass index; CESC cis rs3820928 0.967 rs4675118 chr2:227773157 C/A cg11843606 chr2:227700838 RHBDD1 -0.39 -5.22 -0.31 3.69e-7 Pulmonary function; CESC cis rs9300255 0.698 rs4759416 chr12:123746357 C/G cg00376283 chr12:123451042 ABCB9 0.72 9.0 0.48 4.56e-17 Neutrophil percentage of white cells; CESC cis rs9905704 0.633 rs2018966 chr17:56477565 C/T cg12560992 chr17:57184187 TRIM37 -0.61 -5.75 -0.33 2.49e-8 Testicular germ cell tumor; CESC cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg07636037 chr3:49044803 WDR6 1.07 19.82 0.77 3.09e-54 Parkinson's disease; CESC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg25985355 chr7:65971099 NA 0.32 5.3 0.31 2.4e-7 Aortic root size; CESC cis rs1707322 0.721 rs7519900 chr1:46234947 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.2 0.4 6.12e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1348850 0.914 rs2060929 chr2:178280031 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.86 12.77 0.62 1.97e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7190458 0.522 rs72787110 chr16:75379533 T/C cg04384234 chr16:75411784 CFDP1 0.61 5.17 0.3 4.54e-7 Pancreatic cancer; CESC cis rs11203032 0.831 rs10788638 chr10:90950683 A/G cg16672925 chr10:90967113 CH25H 0.46 5.42 0.32 1.32e-7 Heart failure; CESC cis rs709400 0.604 rs7158144 chr14:103887615 A/G cg12935359 chr14:103987150 CKB -0.56 -8.18 -0.45 1.21e-14 Body mass index; CESC cis rs10927875 1.000 rs10927875 chr1:16299312 A/G cg21385522 chr1:16154831 NA 0.77 9.74 0.51 2.41e-19 Dilated cardiomyopathy; CESC cis rs8060686 0.516 rs7184821 chr16:68270229 T/C cg26727032 chr16:67993705 SLC12A4 -0.6 -8.67 -0.47 4.34e-16 HDL cholesterol;Metabolic syndrome; CESC cis rs12144044 0.701 rs2999159 chr1:113230758 A/G cg22162597 chr1:113214053 CAPZA1 -0.5 -5.26 -0.31 2.91e-7 Glomerular filtration rate (creatinine); CESC cis rs57502260 0.704 rs41478448 chr11:68181621 A/G cg20283391 chr11:68216788 NA -0.57 -5.17 -0.3 4.71e-7 Total body bone mineral density (age 45-60); CESC cis rs61776719 0.520 rs17465651 chr1:38418496 C/T cg17077180 chr1:38461687 NA 0.47 7.15 0.4 8.21e-12 Coronary artery disease; CESC cis rs116095464 1.000 rs56235400 chr5:312625 G/A cg10591111 chr5:226296 SDHA -0.61 -5.73 -0.33 2.73e-8 Breast cancer; CESC cis rs4073582 0.595 rs801737 chr11:65928193 T/C cg14036092 chr11:66035641 RAB1B 0.55 7.76 0.43 1.82e-13 Gout; CESC cis rs2274273 0.837 rs7146748 chr14:55747086 G/A cg04306507 chr14:55594613 LGALS3 0.3 5.84 0.34 1.54e-8 Protein biomarker; CESC cis rs916888 0.610 rs199529 chr17:44837217 A/C cg17911788 chr17:44343683 NA -0.46 -6.74 -0.38 9.64e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2228479 0.702 rs62053702 chr16:89860688 G/T cg14709524 chr16:89940631 TCF25 0.93 6.97 0.39 2.5e-11 Skin colour saturation; CESC cis rs4319547 0.614 rs10846764 chr12:122874297 T/C cg05707623 chr12:122985044 ZCCHC8 0.56 6.28 0.36 1.35e-9 Body mass index; CESC trans rs11098499 0.644 rs7676296 chr4:120555687 A/G cg25214090 chr10:38739885 LOC399744 0.62 8.65 0.47 4.98e-16 Corneal astigmatism; CESC cis rs6540559 0.611 rs61747285 chr1:210004332 G/A cg23283495 chr1:209979779 IRF6 0.47 5.24 0.31 3.24e-7 Cleft lip with or without cleft palate; CESC cis rs765787 0.530 rs12906537 chr15:45520061 T/C cg24006582 chr15:45444508 DUOX1 0.54 6.48 0.37 4.44e-10 Uric acid levels; CESC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.58 0.37 2.48e-10 Bipolar disorder; CESC cis rs4253772 0.550 rs6007779 chr22:46678615 A/C cg18190219 chr22:46762943 CELSR1 -0.42 -5.34 -0.31 2e-7 LDL cholesterol;Cholesterol, total; CESC cis rs1267303 0.716 rs942255 chr1:46989792 C/T cg25110126 chr1:46999211 NA 0.76 8.82 0.48 1.57e-16 Monobrow; CESC cis rs60843830 1.000 rs3791221 chr2:226933 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.35 0.54 2.56e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs17095355 0.748 rs2501577 chr10:111846687 C/T cg00817464 chr10:111662876 XPNPEP1 0.44 5.67 0.33 3.74e-8 Biliary atresia; CESC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg18876405 chr7:65276391 NA 0.45 6.17 0.35 2.49e-9 Aortic root size; CESC cis rs2276314 1.000 rs9956938 chr18:33567061 A/G cg19628046 chr18:33552617 C18orf21 0.5 5.33 0.31 2.1e-7 Endometriosis;Drug-induced torsades de pointes; CESC cis rs4253772 0.550 rs739164 chr22:46684558 C/T cg07012999 chr22:46692446 CN5H6.4;GTSE1 -0.52 -5.28 -0.31 2.64e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4423214 0.879 rs736894 chr11:71152258 A/G cg05163923 chr11:71159392 DHCR7 0.7 8.59 0.47 7.51e-16 Vitamin D levels; CESC cis rs6964587 0.810 rs408 chr7:91556284 A/G cg17063962 chr7:91808500 NA -0.54 -7.15 -0.4 8.24e-12 Breast cancer; CESC cis rs7927771 1.000 rs34910028 chr11:47758449 T/C cg05585544 chr11:47624801 NA -0.52 -8.05 -0.44 2.78e-14 Subjective well-being; CESC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.09 19.75 0.77 5.18e-54 Prudent dietary pattern; CESC cis rs713587 0.713 rs12466350 chr2:25239969 A/G cg01884057 chr2:25150051 NA 0.4 7.62 0.42 4.48e-13 Body mass index in non-asthmatics; CESC cis rs2637266 0.703 rs864677 chr10:78525525 G/A cg18941641 chr10:78392320 NA 0.39 7.68 0.43 3.1400000000000003e-13 Pulmonary function; CESC cis rs7615952 0.932 rs7629977 chr3:125649573 T/G cg05084668 chr3:125655381 ALG1L -0.54 -6.32 -0.36 1.09e-9 Blood pressure (smoking interaction); CESC trans rs7980799 0.682 rs7311794 chr12:33635630 C/T cg26384229 chr12:38710491 ALG10B -0.57 -8.34 -0.46 3.99e-15 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs11718455 0.920 rs13084408 chr3:44008967 G/A cg08738300 chr3:44038990 NA 0.46 6.1 0.35 3.7e-9 Coronary artery disease; CESC cis rs76878669 0.561 rs10896111 chr11:66115690 T/C cg18002602 chr11:66138449 SLC29A2 -0.42 -6.96 -0.39 2.67e-11 Educational attainment (years of education); CESC cis rs1707322 1.000 rs12097761 chr1:46291162 T/C cg03146154 chr1:46216737 IPP 0.78 10.73 0.55 1.5e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1348850 0.526 rs2293475 chr2:178407897 C/T cg23306229 chr2:178417860 TTC30B -0.74 -6.73 -0.38 1.02e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.48 -6.18 -0.35 2.39e-9 Tonsillectomy; CESC cis rs61996546 0.622 rs34661562 chr15:26849631 A/G cg14859324 chr15:26874363 GABRB3 -0.37 -5.06 -0.3 7.97e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg09165964 chr15:75287851 SCAMP5 0.51 7.09 0.4 1.19e-11 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01777103 chr8:145550585 DGAT1 -0.44 -6.11 -0.35 3.58e-9 Fibrinogen levels; CESC cis rs763121 0.853 rs5750671 chr22:39094619 A/C cg06544989 chr22:39130855 UNC84B 0.52 9.88 0.52 8.35e-20 Menopause (age at onset); CESC cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg24531977 chr5:56204891 C5orf35 -0.44 -5.45 -0.32 1.17e-7 Coronary artery disease; CESC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg07701084 chr6:150067640 NUP43 0.41 5.41 0.32 1.41e-7 Lung cancer; CESC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg08736216 chr1:53307985 ZYG11A 0.41 6.85 0.39 5.29e-11 Monocyte count; CESC cis rs7247513 0.790 rs17476839 chr19:12762783 C/T cg01871581 chr19:12707946 ZNF490 0.73 10.72 0.55 1.68e-22 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21680979 chr1:204485559 MDM4 0.55 6.39 0.37 7.25e-10 Gut microbiome composition (summer); CESC cis rs8092503 0.903 rs58243949 chr18:52509833 C/T cg12377874 chr18:52495404 RAB27B 0.39 5.97 0.34 7.63e-9 Childhood body mass index; CESC cis rs12725198 1.000 rs12725833 chr1:16080618 G/A cg18133145 chr1:16060689 PLEKHM2 -0.52 -5.66 -0.33 4e-8 Cardiac Troponin-T levels; CESC cis rs6087990 0.735 rs1855350 chr20:31387525 C/T cg13636640 chr20:31349939 DNMT3B 0.8 12.85 0.62 1.09e-29 Ulcerative colitis; CESC cis rs986417 0.901 rs10139995 chr14:60947177 G/T cg00859478 chr14:60978094 SIX6 0.45 5.06 0.3 7.79e-7 Gut microbiota (bacterial taxa); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg00772714 chr1:15479360 TMEM51;C1orf126 -0.46 -6.21 -0.36 2.09e-9 Recombination measurement; CESC cis rs6582630 0.519 rs11514056 chr12:38284001 G/T cg13010199 chr12:38710504 ALG10B 0.46 5.61 0.33 5.13e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg24549020 chr5:56110836 MAP3K1 0.66 7.45 0.42 1.35e-12 Initial pursuit acceleration; CESC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg18225595 chr11:63971243 STIP1 0.52 5.16 0.3 4.77e-7 Mean platelet volume; CESC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.84 0.55 6.79e-23 Alzheimer's disease; CESC trans rs3942852 0.955 rs7117386 chr11:48125371 G/A cg15704280 chr7:45808275 SEPT13 -0.59 -6.74 -0.38 9.73e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.44 0.61 2.73e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9788682 0.747 rs2568490 chr15:78738370 T/C cg24631222 chr15:78858424 CHRNA5 -0.6 -7.09 -0.4 1.21e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs897080 0.552 rs1085442 chr2:44635454 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.52 0.32 8.08e-8 Height; CESC cis rs9640161 0.702 rs1962004 chr7:150020381 G/A cg10018233 chr7:150070692 REPIN1 0.38 5.23 0.31 3.38e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs6429082 0.608 rs4659838 chr1:235565315 A/G cg26050004 chr1:235667680 B3GALNT2 -0.53 -6.63 -0.38 1.84e-10 Adiposity; CESC cis rs4268898 0.722 rs35520052 chr2:24415277 C/T cg06627628 chr2:24431161 ITSN2 0.6 7.91 0.44 6.79e-14 Asthma; CESC cis rs6060717 0.536 rs6060664 chr20:34478884 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -6.93 -0.39 3.22e-11 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.73 0.64 9.09e-33 Prudent dietary pattern; CESC cis rs3741151 0.656 rs56884659 chr11:73252947 C/G cg17517138 chr11:73019481 ARHGEF17 1.05 7.72 0.43 2.46e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs742614 0.533 rs6059497 chr20:32446960 C/G cg06304546 chr20:32448765 NA -0.48 -6.15 -0.35 2.81e-9 Stearic acid (18:0) levels; CESC cis rs6693567 0.565 rs832621 chr1:150392909 G/C cg09579323 chr1:150459698 TARS2 0.46 5.97 0.34 7.68e-9 Migraine; CESC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.32 -0.31 2.21e-7 Total body bone mineral density; CESC cis rs3791556 0.501 rs3791536 chr2:240101713 G/A cg03281426 chr2:240109471 HDAC4 0.47 5.94 0.34 9.16e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC cis rs3125734 0.608 rs7905731 chr10:64018472 T/C cg09941381 chr10:64027924 RTKN2 -0.32 -5.21 -0.3 3.79e-7 Rheumatoid arthritis; CESC cis rs61542988 0.570 rs62448267 chr7:22822501 T/C cg11367502 chr7:22862612 TOMM7 0.54 6.29 0.36 1.3e-9 Fibrinogen levels; CESC cis rs77972916 0.611 rs11693190 chr2:43602415 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -6.05 -0.35 5.04e-9 Granulocyte percentage of myeloid white cells; CESC cis rs7524258 0.868 rs2412152 chr1:7303213 C/T cg07173049 chr1:7289937 CAMTA1 0.42 6.27 0.36 1.5e-9 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs992157 0.687 rs10206984 chr2:219066980 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.56 0.51 8.5e-19 Colorectal cancer; CESC cis rs8067545 0.611 rs2526465 chr17:20167611 T/C cg13482628 chr17:19912719 NA -0.42 -5.6 -0.33 5.37e-8 Schizophrenia; CESC cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg01579765 chr21:45077557 HSF2BP -0.56 -9.31 -0.5 5.09e-18 Mean corpuscular volume; CESC cis rs478222 0.866 rs11684464 chr2:25340610 A/G cg01884057 chr2:25150051 NA -0.3 -5.08 -0.3 7.24e-7 Type 1 diabetes; CESC cis rs4129767 0.869 rs4969142 chr17:76398304 G/A cg05887092 chr17:76393375 PGS1 0.68 11.21 0.57 4.1e-24 HDL cholesterol; CESC cis rs367943 0.712 rs10042223 chr5:112712832 C/T cg12552261 chr5:112820674 MCC 0.39 5.2 0.3 4e-7 Type 2 diabetes; CESC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC trans rs11148252 0.574 rs61958118 chr13:53170226 C/T cg18335740 chr13:41363409 SLC25A15 0.57 7.92 0.44 6.73e-14 Lewy body disease; CESC cis rs12142240 0.583 rs5013330 chr1:46815154 G/A cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs3092073 0.624 rs11696196 chr20:44574533 C/T cg17986701 chr20:44574422 PCIF1 0.35 5.22 0.31 3.62e-7 Intelligence (multi-trait analysis); CESC cis rs6032067 0.866 rs2233901 chr20:43851094 A/G cg10761708 chr20:43804764 PI3 -0.5 -6.28 -0.36 1.4e-9 Blood protein levels; CESC cis rs4629180 0.630 rs10188189 chr2:102127926 A/G cg04415270 chr2:102091202 RFX8 -0.34 -5.95 -0.34 8.64e-9 Chronic rhinosinusitis with nasal polyps; CESC cis rs9443189 0.950 rs1280039 chr6:76514940 C/T cg01950844 chr6:76311363 SENP6 0.64 6.54 0.37 3.09e-10 Prostate cancer; CESC cis rs10851478 0.872 rs62022665 chr15:49873811 G/C cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.16 0.3 4.75e-7 Oral cavity cancer; CESC cis rs826838 1.000 rs826851 chr12:39112639 A/G cg26384229 chr12:38710491 ALG10B -0.7 -11.43 -0.57 7.55e-25 Heart rate; CESC cis rs11683229 0.704 rs12996320 chr2:63310229 C/T cg17519650 chr2:63277830 OTX1 0.62 5.12 0.3 6.01e-7 Protein quantitative trait loci; CESC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.3 -0.57 2.05e-24 Type 2 diabetes; CESC cis rs3820068 0.581 rs72645874 chr1:15926238 C/G cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs7937682 1.000 rs2186839 chr11:111534442 T/G cg22437258 chr11:111473054 SIK2 0.7 9.23 0.49 9.06e-18 Primary sclerosing cholangitis; CESC cis rs6580649 0.941 rs1859441 chr12:48423233 C/T cg24011408 chr12:48396354 COL2A1 -0.42 -5.26 -0.31 2.93e-7 Lung cancer; CESC cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg03433033 chr1:76189801 ACADM -0.63 -6.61 -0.38 2.14e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg09165964 chr15:75287851 SCAMP5 -0.45 -6.15 -0.35 2.89e-9 Breast cancer; CESC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg04369109 chr6:150039330 LATS1 -0.44 -6.17 -0.35 2.52e-9 Lung cancer; CESC cis rs7084402 0.967 rs1620186 chr10:60314275 G/A cg07615347 chr10:60278583 BICC1 0.62 9.95 0.52 5.08e-20 Refractive error; CESC cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg05343316 chr1:45956843 TESK2 -0.5 -6.45 -0.37 5.14e-10 High light scatter reticulocyte count; CESC trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -7.17 -0.4 7.55e-12 Neuroticism; CESC cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.69 -8.64 -0.47 5.38e-16 Multiple sclerosis; CESC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg01546378 chr2:38892901 GALM -0.5 -6.7 -0.38 1.24e-10 5-HTT brain serotonin transporter levels; CESC cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg21385522 chr1:16154831 NA -0.61 -7.58 -0.42 5.89e-13 Dilated cardiomyopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.18.486455F chr18:23949690 TAF4B -0.53 -6.36 -0.36 8.81e-10 Gut microbiome composition (summer); CESC cis rs9488822 0.676 rs12202641 chr6:116314634 A/G cg26893134 chr6:116381904 FRK -0.26 -6.5 -0.37 3.96e-10 Cholesterol, total;LDL cholesterol; CESC cis rs11098499 0.644 rs3986377 chr4:120260270 G/A cg09307838 chr4:120376055 NA 0.76 10.33 0.54 3.09e-21 Corneal astigmatism; CESC trans rs17685 0.753 rs10245584 chr7:75745866 C/T cg19862616 chr7:65841803 NCRNA00174 0.84 12.42 0.61 3.1e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg27266027 chr21:40555129 PSMG1 0.46 5.37 0.31 1.72e-7 Cognitive function; CESC cis rs7267979 1.000 rs6083804 chr20:25317060 A/G cg08601574 chr20:25228251 PYGB -0.39 -5.61 -0.33 4.99e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7818688 0.697 rs61591488 chr8:95984955 C/T cg16049864 chr8:95962084 TP53INP1 0.57 5.73 0.33 2.68e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg02487422 chr3:49467188 NICN1 0.39 5.05 0.3 8.06e-7 Parkinson's disease; CESC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg23018236 chr17:30244563 NA -0.52 -5.59 -0.32 5.57e-8 Hip circumference adjusted for BMI; CESC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.76e-12 Tonsillectomy; CESC cis rs758324 0.853 rs10051653 chr5:131248894 G/A cg06307176 chr5:131281290 NA -0.37 -5.06 -0.3 7.79e-7 Alzheimer's disease in APOE e4- carriers; CESC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg07507251 chr3:52567010 NT5DC2 0.4 7.03 0.4 1.78e-11 Bipolar disorder; CESC cis rs36051895 0.695 rs7045000 chr9:5015143 G/A cg02405213 chr9:5042618 JAK2 -0.48 -6.0 -0.35 6.46e-9 Pediatric autoimmune diseases; CESC cis rs7223966 1.000 rs9891018 chr17:61827856 A/G cg11494091 chr17:61959527 GH2 0.39 5.22 0.31 3.59e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs3741151 1.000 rs75109191 chr11:73023532 T/C cg17517138 chr11:73019481 ARHGEF17 1.16 8.06 0.44 2.63e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.61 7.94 0.44 5.84e-14 Prudent dietary pattern; CESC cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg11764359 chr7:65958608 NA 0.8 8.97 0.48 5.55e-17 Aortic root size; CESC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg21770322 chr7:97807741 LMTK2 -0.56 -8.61 -0.47 6.79e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs2204008 0.837 rs2387317 chr12:38235319 T/C cg13010199 chr12:38710504 ALG10B 0.49 6.1 0.35 3.78e-9 Bladder cancer; CESC cis rs4833079 0.562 rs11944291 chr4:38631620 T/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.48 6.69 0.38 1.34e-10 Body mass index; CESC cis rs933688 1.000 rs6867091 chr5:90734333 C/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.06 14.58 0.67 9.41e-36 Smoking behavior; CESC cis rs3768617 0.510 rs2093985 chr1:183094322 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.25 0.63 4.17e-31 Fuchs's corneal dystrophy; CESC cis rs9828933 1.000 rs9828933 chr3:64002897 T/C cg16258503 chr3:63850278 ATXN7;THOC7 -0.52 -5.21 -0.3 3.74e-7 Type 2 diabetes; CESC cis rs7512552 0.839 rs2647373 chr1:150320570 G/C cg15654264 chr1:150340011 RPRD2 0.39 5.16 0.3 4.81e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs2933343 0.729 rs1680780 chr3:128612659 G/C cg25356066 chr3:128598488 ACAD9 0.63 8.58 0.47 8.01e-16 IgG glycosylation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10909163 chr13:41635251 WBP4 -0.43 -6.11 -0.35 3.53e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6545883 1.000 rs778758 chr2:61782161 T/C cg15711740 chr2:61764176 XPO1 -0.43 -5.33 -0.31 2.14e-7 Tuberculosis; CESC cis rs9910055 0.509 rs9916444 chr17:42313512 C/G cg08499158 chr17:42289980 UBTF -0.42 -5.18 -0.3 4.32e-7 Total body bone mineral density; CESC cis rs2011503 0.941 rs11670775 chr19:19649636 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.13 0.3 5.7e-7 Bipolar disorder; CESC cis rs57083693 0.556 rs6538984 chr12:101725669 T/G cg22051763 chr12:101673672 UTP20 -0.44 -5.5 -0.32 8.98e-8 Alcohol dependence (age at onset); CESC cis rs7202877 0.539 rs17764278 chr16:75374029 A/T cg04384234 chr16:75411784 CFDP1 -0.63 -5.52 -0.32 8.2e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg19774624 chr17:42201019 HDAC5 -0.69 -10.1 -0.53 1.62e-20 Total body bone mineral density; CESC cis rs8067354 0.574 rs2526354 chr17:57976658 A/G cg13753209 chr17:57696993 CLTC 0.54 6.03 0.35 5.57e-9 Hemoglobin concentration; CESC cis rs7208859 0.673 rs1347360 chr17:28914532 T/C cg19761014 chr17:28927070 LRRC37B2 0.7 5.97 0.34 7.4e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg19052272 chr2:3704530 ALLC -0.48 -5.85 -0.34 1.41e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs73206853 0.764 rs73206857 chr12:110767721 T/A cg12870014 chr12:110450643 ANKRD13A 0.67 5.67 0.33 3.67e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9393777 0.623 rs7773938 chr6:26474044 C/T cg12826209 chr6:26865740 GUSBL1 0.67 7.12 0.4 9.9e-12 Intelligence (multi-trait analysis); CESC cis rs7953249 0.656 rs6489786 chr12:121397875 A/G cg02403541 chr12:121454288 C12orf43 -0.53 -6.9 -0.39 3.77e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg18145393 chr4:520203 PIGG -0.51 -6.62 -0.38 1.95e-10 Post-traumatic stress disorder; CESC trans rs1340425 0.793 rs67551075 chr1:74441371 T/C cg26500312 chr17:30821755 MYO1D 0.55 6.13 0.35 3.09e-9 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg00149659 chr3:10157352 C3orf10 0.97 11.51 0.58 3.85e-25 Alzheimer's disease; CESC cis rs4242434 0.819 rs720745 chr8:22471147 G/T cg03733263 chr8:22462867 KIAA1967 0.86 14.44 0.66 2.98e-35 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs8014204 0.868 rs2230237 chr14:75359670 G/A cg08847533 chr14:75593920 NEK9 -0.46 -5.68 -0.33 3.46e-8 Caffeine consumption; CESC cis rs7481584 0.624 rs511990 chr11:3052936 A/G cg08508325 chr11:3079039 CARS 0.29 5.19 0.3 4.29e-7 Calcium levels; CESC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg19046167 chr17:80928561 B3GNTL1 0.4 5.34 0.31 2.04e-7 Breast cancer; CESC cis rs7927592 0.763 rs10896326 chr11:68234571 T/C cg01657329 chr11:68192670 LRP5 -0.47 -6.19 -0.36 2.29e-9 Total body bone mineral density; CESC cis rs9916302 0.851 rs677888 chr17:37461018 T/G cg00129232 chr17:37814104 STARD3 0.51 6.26 0.36 1.58e-9 Glomerular filtration rate (creatinine); CESC cis rs12579753 0.810 rs10862355 chr12:82162698 C/T cg23701643 chr12:82153290 PPFIA2 -0.33 -5.07 -0.3 7.33e-7 Resting heart rate; CESC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg24531977 chr5:56204891 C5orf35 -0.84 -10.77 -0.55 1.09e-22 Initial pursuit acceleration; CESC cis rs798766 0.953 rs798751 chr4:1719572 A/G cg10756475 chr4:1757242 NA 0.44 5.97 0.34 7.54e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs4588572 0.644 rs10061149 chr5:77744201 G/A cg11547950 chr5:77652471 NA -0.4 -5.46 -0.32 1.12e-7 Triglycerides; CESC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg13733410 chr7:12443478 VWDE -0.48 -5.78 -0.33 2.07e-8 Coronary artery disease; CESC cis rs9467711 0.606 rs12176317 chr6:26372786 A/G cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.07e-9 Autism spectrum disorder or schizophrenia; CESC cis rs6088580 0.634 rs6059779 chr20:32950325 C/T cg24642439 chr20:33292090 TP53INP2 -0.51 -6.66 -0.38 1.6e-10 Glomerular filtration rate (creatinine); CESC cis rs4944092 1.000 rs4944092 chr11:75909619 C/T cg04588336 chr11:75916460 WNT11 -0.48 -7.7 -0.43 2.78e-13 PR interval; CESC cis rs7727544 0.684 rs611084 chr5:131709739 A/C cg07395648 chr5:131743802 NA 0.42 5.49 0.32 9.52e-8 Blood metabolite levels; CESC cis rs1215050 0.791 rs13114823 chr4:98671119 G/A cg05340658 chr4:99064831 C4orf37 -0.47 -6.09 -0.35 3.86e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg20151795 chr6:28129481 ZNF389 0.48 6.12 0.35 3.35e-9 Depression; CESC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg03647317 chr4:187891568 NA -0.37 -5.56 -0.32 6.44e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs4423214 1.000 rs2282620 chr11:71183477 C/T cg24826892 chr11:71159390 DHCR7 0.46 5.24 0.31 3.2e-7 Vitamin D levels; CESC cis rs6088590 1.000 rs6119535 chr20:33442138 A/C cg06115741 chr20:33292138 TP53INP2 0.55 6.84 0.39 5.34e-11 Coronary artery disease; CESC cis rs30380 0.690 rs2216752 chr5:96185467 A/G cg16492584 chr5:96139282 ERAP1 0.37 5.07 0.3 7.43e-7 Cerebrospinal fluid biomarker levels; CESC cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.88 0.34 1.21e-8 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg03676636 chr4:99064102 C4orf37 0.34 5.15 0.3 5e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12059507 chr11:62606662 WDR74 0.55 6.11 0.35 3.58e-9 Gut microbiome composition (summer); CESC cis rs10256972 0.527 rs2949170 chr7:1216438 A/G cg17541715 chr7:1216824 NA -0.39 -5.05 -0.3 8.42e-7 Longevity;Endometriosis; CESC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.03 0.4 1.78e-11 Height; CESC cis rs11122272 0.735 rs2491416 chr1:231547335 T/C cg06096015 chr1:231504339 EGLN1 -0.42 -5.93 -0.34 9.56e-9 Hemoglobin concentration; CESC cis rs9811920 0.809 rs35422475 chr3:99711545 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -7.53 -0.42 7.76e-13 Axial length; CESC cis rs9796 0.662 rs8033435 chr15:41436479 C/T cg12426344 chr15:41135900 SPINT1 -0.25 -5.39 -0.31 1.59e-7 Menopause (age at onset); CESC trans rs61931739 0.500 rs11053201 chr12:34453903 T/A cg26384229 chr12:38710491 ALG10B 0.69 10.44 0.54 1.34e-21 Morning vs. evening chronotype; CESC cis rs921968 0.540 rs646295 chr2:219408558 A/C cg02176678 chr2:219576539 TTLL4 0.43 7.65 0.43 3.67e-13 Mean corpuscular hemoglobin concentration; CESC cis rs11252926 0.537 rs4881255 chr10:453638 T/C cg16386425 chr10:429943 DIP2C -0.56 -7.18 -0.4 7.03e-12 Psychosis in Alzheimer's disease; CESC cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 -0.42 -5.41 -0.32 1.38e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7537052 0.646 rs795045 chr1:36650055 T/C cg24686825 chr1:36642396 MAP7D1 -0.71 -10.0 -0.52 3.38e-20 Schizophrenia; CESC cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg17211192 chr8:82754475 SNX16 -0.67 -8.1 -0.45 2.01e-14 Diastolic blood pressure; CESC cis rs6687430 0.543 rs7512495 chr1:10631237 C/T cg07384165 chr1:10488281 NA -0.47 -6.54 -0.37 3.08e-10 Hand grip strength; CESC cis rs4072980 0.545 rs10890285 chr1:38453576 A/C cg12658694 chr1:38397304 INPP5B -0.67 -8.87 -0.48 1.1e-16 Coronary artery disease; CESC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg03060546 chr3:49711283 APEH 0.47 5.9 0.34 1.08e-8 Parkinson's disease; CESC cis rs2404602 0.647 rs12904417 chr15:76964152 A/G cg23625390 chr15:77176239 SCAPER 0.46 6.57 0.37 2.71e-10 Blood metabolite levels; CESC cis rs344364 0.636 rs344363 chr16:1972548 C/T cg26617929 chr16:1858877 NA -0.52 -5.12 -0.3 5.8e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs2294693 0.685 rs67525613 chr6:41008956 G/T cg14769373 chr6:40998127 UNC5CL -0.43 -5.17 -0.3 4.65e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs10242455 0.702 rs76702117 chr7:98916779 A/G cg25640893 chr7:99214727 ZNF498 0.9 6.04 0.35 5.13e-9 Blood metabolite levels; CESC cis rs9487051 0.768 rs351752 chr6:109536034 C/A cg01475377 chr6:109611718 NA -0.44 -6.76 -0.38 8.56e-11 Reticulocyte fraction of red cells; CESC cis rs7726839 1.000 rs7726839 chr5:618586 A/G cg16447950 chr5:562315 NA -0.4 -5.2 -0.3 4.03e-7 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10318825 chr7:75611554 POR 0.43 6.2 0.36 2.12e-9 Fibrinogen levels; CESC cis rs7527798 0.592 rs12025522 chr1:207854355 A/C cg09232269 chr1:207846808 CR1L 0.28 5.07 0.3 7.41e-7 Erythrocyte sedimentation rate; CESC cis rs1707322 1.000 rs34444543 chr1:46358862 G/A cg05343316 chr1:45956843 TESK2 0.45 5.55 0.32 6.98e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs847577 0.609 rs7791463 chr7:97819047 G/A cg21770322 chr7:97807741 LMTK2 0.84 13.94 0.65 1.67e-33 Breast cancer; CESC cis rs593982 0.925 rs585272 chr11:65505289 A/G cg08755490 chr11:65554678 OVOL1 1.32 20.05 0.78 4.7e-55 Atopic dermatitis; CESC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg25427524 chr10:38739819 LOC399744 0.69 10.31 0.54 3.49e-21 Extrinsic epigenetic age acceleration; CESC cis rs9291683 0.595 rs3733585 chr4:10036339 A/G cg00071950 chr4:10020882 SLC2A9 0.87 15.5 0.69 5.06e-39 Bone mineral density; CESC cis rs17601876 0.814 rs7181429 chr15:51559496 G/A cg19946085 chr15:51559439 CYP19A1 -0.33 -5.39 -0.31 1.54e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg13783546 chr17:76671452 CYTH1 -0.49 -6.03 -0.35 5.6e-9 Psoriatic arthritis; CESC cis rs4237845 0.844 rs4628718 chr12:58301600 A/C cg02175503 chr12:58329896 NA 0.66 8.31 0.45 5.16e-15 Intelligence (multi-trait analysis); CESC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.38 0.31 1.66e-7 Tonsillectomy; CESC cis rs5771225 0.563 rs738334 chr22:50688235 T/C cg16473166 chr22:50639996 SELO 0.46 5.18 0.3 4.36e-7 Late-onset Alzheimer's disease; CESC trans rs916888 0.773 rs199439 chr17:44793503 A/G cg27125505 chr17:43679177 LOC644172 0.49 6.46 0.37 4.88e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2072732 0.861 rs1890338 chr1:2949028 C/T cg15211996 chr1:2936768 ACTRT2 0.35 6.12 0.35 3.42e-9 Plateletcrit; CESC cis rs12765878 1.000 rs4918067 chr10:105644636 A/C cg24587175 chr10:105670608 OBFC1 0.31 5.07 0.3 7.48e-7 Coronary artery disease; CESC trans rs66573146 1.000 rs28729690 chr4:6962061 C/T cg07817883 chr1:32538562 TMEM39B 1.36 8.74 0.47 2.78e-16 Granulocyte percentage of myeloid white cells; CESC cis rs367615 0.513 rs11741087 chr5:108807760 G/A cg17395555 chr5:108820864 NA 0.62 10.04 0.53 2.55e-20 Colorectal cancer (SNP x SNP interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09351035 chr11:748060 TALDO1 0.49 6.16 0.35 2.64e-9 Gut microbiota (bacterial taxa); CESC cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg06115741 chr20:33292138 TP53INP2 0.48 5.89 0.34 1.16e-8 Coronary artery disease; CESC cis rs8067354 0.645 rs2665400 chr17:57880201 G/A cg13753209 chr17:57696993 CLTC 0.66 8.34 0.46 4.12e-15 Hemoglobin concentration; CESC cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg22875332 chr1:76189707 ACADM 0.59 5.77 0.33 2.27e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9549367 0.713 rs3024764 chr13:113824314 A/G cg18105134 chr13:113819100 PROZ -0.63 -7.92 -0.44 6.5e-14 Platelet distribution width; CESC cis rs593982 0.777 rs72941015 chr11:65457514 A/C cg08755490 chr11:65554678 OVOL1 -1.21 -8.91 -0.48 8.27e-17 Atopic dermatitis; CESC cis rs12042052 1.000 rs72754230 chr1:232935071 A/G cg00951395 chr1:232941775 KIAA1383 0.83 7.03 0.4 1.73e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs7100689 0.784 rs6585986 chr10:82171559 T/C cg00277334 chr10:82204260 NA -0.57 -7.11 -0.4 1.09e-11 Post bronchodilator FEV1; CESC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg05564831 chr3:52568323 NT5DC2 0.45 6.87 0.39 4.46e-11 Bipolar disorder; CESC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg26314531 chr2:26401878 FAM59B -0.71 -7.89 -0.44 8.08e-14 Gut microbiome composition (summer); CESC cis rs2777491 0.957 rs8027626 chr15:41711514 T/G cg20272979 chr15:41787780 ITPKA 0.45 6.62 0.38 1.94e-10 Ulcerative colitis; CESC cis rs7586879 0.616 rs12713422 chr2:25134497 A/C cg01884057 chr2:25150051 NA 0.36 7.02 0.4 1.84e-11 Body mass index; CESC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg24399712 chr22:39784796 NA -0.78 -9.96 -0.52 4.84e-20 Intelligence (multi-trait analysis); CESC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.32 0.41 3.05e-12 Tonsillectomy; CESC cis rs9911578 0.935 rs302873 chr17:56769481 C/G cg12560992 chr17:57184187 TRIM37 0.93 15.26 0.68 3.64e-38 Intelligence (multi-trait analysis); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg18875839 chr8:29120848 KIF13B -0.46 -6.14 -0.35 3.04e-9 Height; CESC cis rs6460942 0.630 rs1866650 chr7:12396897 C/T cg20607287 chr7:12443886 VWDE -0.64 -6.82 -0.39 6.18e-11 Coronary artery disease; CESC cis rs9611565 0.506 rs2024567 chr22:41699206 G/C cg06481639 chr22:41940642 POLR3H -0.52 -5.74 -0.33 2.57e-8 Vitiligo; CESC cis rs67311347 0.544 rs13098483 chr3:40342743 G/C cg09455208 chr3:40491958 NA 0.37 6.51 0.37 3.77e-10 Renal cell carcinoma; CESC cis rs6500395 0.775 rs28481630 chr16:48663664 G/C cg04672837 chr16:48644449 N4BP1 0.49 6.27 0.36 1.46e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2072499 0.722 rs61462713 chr1:156161682 C/T cg25208724 chr1:156163844 SLC25A44 1.01 12.84 0.62 1.13e-29 Testicular germ cell tumor; CESC cis rs3741151 0.773 rs7950375 chr11:73281345 G/A cg17517138 chr11:73019481 ARHGEF17 1.02 7.54 0.42 7.35e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14253848 chr9:131038517 GOLGA2;C9orf119 0.6 6.48 0.37 4.56e-10 Gut microbiome composition (summer); CESC cis rs7107174 0.901 rs2512525 chr11:77923019 T/C cg02023728 chr11:77925099 USP35 0.45 6.01 0.35 6.06e-9 Testicular germ cell tumor; CESC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg17971929 chr21:40555470 PSMG1 -0.87 -12.61 -0.61 6.96e-29 Cognitive function; CESC cis rs9902453 0.612 rs2617868 chr17:28073247 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.76 -10.2 -0.53 8.08e-21 Coffee consumption (cups per day); CESC cis rs2404602 0.647 rs12903331 chr15:77168268 C/G cg23625390 chr15:77176239 SCAPER -0.45 -6.34 -0.36 1.01e-9 Blood metabolite levels; CESC cis rs25645 0.800 rs34003767 chr17:38194296 A/G cg17467752 chr17:38218738 THRA -0.52 -6.75 -0.38 9.49e-11 Myeloid white cell count; CESC trans rs877282 0.583 rs112372193 chr10:826602 A/G cg22713356 chr15:30763199 NA 1.02 9.67 0.51 3.88e-19 Uric acid levels; CESC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg20916646 chr4:852691 GAK 0.43 5.92 0.34 1e-8 Sjögren's syndrome; CESC cis rs7520050 0.667 rs11211176 chr1:46223086 C/T cg03146154 chr1:46216737 IPP -0.61 -8.28 -0.45 6.01e-15 Red blood cell count;Reticulocyte count; CESC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg21951975 chr1:209979733 IRF6 0.61 9.44 0.5 2e-18 Cleft lip with or without cleft palate; CESC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg05863683 chr7:1912471 MAD1L1 0.5 7.78 0.43 1.58e-13 Bipolar disorder and schizophrenia; CESC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg11494091 chr17:61959527 GH2 0.73 12.71 0.62 3.32e-29 Prudent dietary pattern; CESC cis rs35110281 0.565 rs7278003 chr21:44966069 T/C cg01579765 chr21:45077557 HSF2BP -0.5 -8.26 -0.45 7.04e-15 Mean corpuscular volume; CESC cis rs17376456 0.877 rs10213956 chr5:93460839 C/T cg25358565 chr5:93447407 FAM172A 1.15 11.35 0.57 1.34e-24 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03195269 chr13:50510427 C13orf1 0.53 6.04 0.35 5.2e-9 Gut microbiome composition (summer); CESC trans rs208520 0.690 rs12192710 chr6:66718137 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 12.17 0.6 2.34e-27 Exhaled nitric oxide output; CESC cis rs4253772 0.530 rs9615349 chr22:46732418 T/G cg10541313 chr22:46663664 TTC38 0.75 5.27 0.31 2.88e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2486288 0.656 rs9921035 chr15:45546660 C/T cg21132104 chr15:45694354 SPATA5L1 -0.52 -6.07 -0.35 4.48e-9 Glomerular filtration rate; CESC cis rs79349575 0.749 rs58838744 chr17:46998902 A/G cg16584676 chr17:46985605 UBE2Z 0.54 6.7 0.38 1.24e-10 Type 2 diabetes; CESC cis rs1950626 0.743 rs12884454 chr14:101465627 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.84 10.54 0.54 6.45e-22 Pelvic organ prolapse (moderate/severe); CESC trans rs10411161 0.702 rs7256926 chr19:52391988 A/G cg22319618 chr22:45562946 NUP50 -0.74 -7.44 -0.42 1.37e-12 Breast cancer; CESC cis rs7662987 0.517 rs2602873 chr4:100039032 G/C cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC cis rs637571 0.522 rs606978 chr11:65711517 A/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 5.86 0.34 1.37e-8 Eosinophil percentage of white cells; CESC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg22143856 chr6:28129313 ZNF389 0.45 5.62 0.33 4.71e-8 Parkinson's disease; CESC cis rs12545109 0.879 rs1975285 chr8:57358682 G/C cg09654669 chr8:57350985 NA -0.59 -6.92 -0.39 3.32e-11 Obesity-related traits; CESC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg18099408 chr3:52552593 STAB1 -0.34 -5.84 -0.34 1.49e-8 Bipolar disorder; CESC cis rs71636778 0.596 rs2095637 chr1:27232845 A/G cg12203394 chr1:27248618 NUDC 0.66 5.55 0.32 6.85e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs854765 0.534 rs7207461 chr17:17949789 T/G cg09796270 chr17:17721594 SREBF1 -0.38 -5.04 -0.3 8.49e-7 Total body bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21583412 chr17:27621436 NUFIP2 -0.43 -6.25 -0.36 1.61e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs79839061 0.610 rs78590562 chr4:869715 C/T cg07828340 chr4:882639 GAK 1.07 8.26 0.45 6.86e-15 Intelligence (multi-trait analysis); CESC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg04511125 chr2:88470314 THNSL2 -0.52 -7.66 -0.43 3.41e-13 Response to metformin (IC50); CESC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg18512352 chr11:47633146 NA 0.44 6.35 0.36 9.06e-10 Subjective well-being; CESC cis rs6087990 0.899 rs1333469 chr20:31361249 C/T cg13636640 chr20:31349939 DNMT3B 0.92 16.43 0.71 2.65e-42 Ulcerative colitis; CESC cis rs2404602 0.692 rs34181263 chr15:77065388 C/T cg22467129 chr15:76604101 ETFA -0.34 -5.1 -0.3 6.54e-7 Blood metabolite levels; CESC cis rs4805272 0.539 rs1075733 chr19:29324460 C/T cg12756686 chr19:29218302 NA 0.5 6.33 0.36 1.06e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.3 0.53 3.87e-21 Prudent dietary pattern; CESC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg08888203 chr3:10149979 C3orf24 0.48 6.19 0.36 2.33e-9 Alzheimer's disease; CESC cis rs2836633 0.929 rs11701577 chr21:40028906 C/T cg05519781 chr21:40033154 ERG 0.78 13.14 0.63 1.03e-30 Coronary artery disease; CESC cis rs66561647 0.929 rs67423398 chr8:128972220 C/T cg05480350 chr8:128972681 MIR1205;PVT1 0.58 8.11 0.45 1.91e-14 Hemoglobin concentration; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg19403339 chr2:183580841 DNAJC10 0.41 6.13 0.35 3.14e-9 Vertical cup-disc ratio; CESC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.43 0.37 5.92e-10 Bipolar disorder; CESC cis rs9486719 0.947 rs2499801 chr6:96854594 G/A cg18709589 chr6:96969512 KIAA0776 0.54 5.66 0.33 3.9e-8 Migraine;Coronary artery disease; CESC cis rs7246865 0.531 rs8103913 chr19:17166229 G/C cg16202187 chr19:17186497 HAUS8;MYO9B 0.51 6.7 0.38 1.21e-10 Reticulocyte fraction of red cells; CESC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs2742234 0.590 rs1254962 chr10:43696992 G/A cg07801480 chr10:43725741 RASGEF1A -0.41 -5.33 -0.31 2.14e-7 Hirschsprung disease; CESC cis rs13385 0.769 rs6872766 chr5:139595614 A/C cg26211634 chr5:139558579 C5orf32 0.46 5.13 0.3 5.68e-7 Atrial fibrillation; CESC cis rs6121246 0.559 rs6060933 chr20:30351903 C/T cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.59 0.38 2.42e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg14298792 chr15:30685198 CHRFAM7A -0.49 -5.93 -0.34 9.3e-9 Huntington's disease progression; CESC cis rs28489187 0.683 rs6671599 chr1:85858857 T/C cg16011679 chr1:85725395 C1orf52 -0.47 -5.61 -0.33 5.17e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs9611565 0.921 rs6002333 chr22:41719469 C/T cg03806693 chr22:41940476 POLR3H -0.93 -10.55 -0.54 5.74e-22 Vitiligo; CESC cis rs17818399 0.749 rs13000560 chr2:46790997 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.52 -5.61 -0.33 5.16e-8 Height; CESC cis rs7089973 0.604 rs55759483 chr10:116573423 T/C cg23260525 chr10:116636907 FAM160B1 0.39 7.32 0.41 2.97e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9470366 0.816 rs7774130 chr6:36623756 C/T cg08179530 chr6:36648295 CDKN1A 0.56 6.68 0.38 1.41e-10 QRS duration; CESC cis rs1949733 0.523 rs4619877 chr4:8543235 G/A cg11789530 chr4:8429930 ACOX3 -0.57 -7.18 -0.4 7.24e-12 Response to antineoplastic agents; CESC cis rs2625529 0.526 rs8032222 chr15:72479178 C/G cg16672083 chr15:72433130 SENP8 0.46 6.83 0.39 5.7e-11 Red blood cell count; CESC cis rs2635047 1.000 rs2635045 chr18:44668417 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 6.58 0.37 2.47e-10 Educational attainment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12467960 chr11:68201194 LRP5 -0.57 -6.1 -0.35 3.73e-9 Gut microbiome composition (summer); CESC trans rs13360092 1.000 rs10076846 chr5:50534292 A/T cg03200537 chr16:87022121 NA -0.67 -6.24 -0.36 1.77e-9 Verbal declarative memory; CESC cis rs9902453 0.765 rs8071576 chr17:28188554 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.97 0.48 5.59e-17 Coffee consumption (cups per day); CESC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg18876405 chr7:65276391 NA 0.52 6.98 0.39 2.44e-11 Aortic root size; CESC cis rs4253772 0.550 rs6008598 chr22:46704243 C/T cg24881330 chr22:46731750 TRMU 0.84 7.59 0.42 5.62e-13 LDL cholesterol;Cholesterol, total; CESC cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg23000734 chr10:126850823 CTBP2 -0.68 -11.07 -0.56 1.16e-23 Menarche (age at onset); CESC cis rs8072100 0.713 rs4968257 chr17:45430534 A/G cg08085267 chr17:45401833 C17orf57 -0.53 -6.65 -0.38 1.65e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs10208940 0.920 rs11886343 chr2:68750336 G/A cg12452813 chr2:68675892 NA 0.51 5.1 0.3 6.39e-7 Urate levels in lean individuals; CESC cis rs933688 1.000 rs6869717 chr5:90694797 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 12.36 0.6 5.17e-28 Smoking behavior; CESC trans rs877282 0.945 rs35342920 chr10:790484 T/C cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs4900538 0.855 rs60215817 chr14:102873886 A/G cg18135206 chr14:102964638 TECPR2 -0.73 -9.33 -0.5 4.35e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23927983 chr2:179315956 PRKRA;MIR548N;DFNB59 0.57 6.3 0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs7914558 0.966 rs10786745 chr10:104956827 A/G cg04362960 chr10:104952993 NT5C2 0.48 6.41 0.37 6.53e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg10691866 chr7:65817282 TPST1 0.34 5.54 0.32 7.19e-8 Aortic root size; CESC cis rs6831352 0.959 rs1139490 chr4:100045141 C/T cg12011299 chr4:100065546 ADH4 0.67 8.64 0.47 5.48e-16 Alcohol dependence; CESC cis rs9527 0.590 rs10786744 chr10:104945028 A/C cg04362960 chr10:104952993 NT5C2 -0.4 -5.07 -0.3 7.58e-7 Arsenic metabolism; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg25709441 chr19:44507025 ZNF230 0.53 7.13 0.4 9.68e-12 Retinol levels; CESC trans rs561341 1.000 rs8064843 chr17:30245744 A/G cg27661571 chr11:113659931 NA -0.57 -6.2 -0.36 2.17e-9 Hip circumference adjusted for BMI; CESC cis rs6690583 0.524 rs12030837 chr1:85519383 A/G cg22153463 chr1:85462885 MCOLN2 -0.75 -7.2 -0.4 6.19e-12 Serum sulfate level; CESC cis rs3092073 0.624 rs13040315 chr20:44585793 A/G cg27529037 chr20:44575021 PCIF1 0.56 8.71 0.47 3.28e-16 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27391037 chr22:18560705 PEX26 0.55 6.52 0.37 3.64e-10 Gut microbiome composition (summer); CESC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg13607699 chr17:42295918 UBTF -0.51 -6.31 -0.36 1.14e-9 Total body bone mineral density; CESC cis rs651907 0.557 rs2318090 chr3:101474933 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 6.77 0.38 8.14e-11 Colorectal cancer; CESC cis rs2070488 1.000 rs6772046 chr3:38479660 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 16.04 0.7 6.47e-41 Electrocardiographic conduction measures; CESC cis rs6460942 0.597 rs62449509 chr7:12515013 C/T cg02935154 chr7:12443704 VWDE -0.54 -5.5 -0.32 9.08e-8 Coronary artery disease; CESC cis rs637571 0.546 rs10791827 chr11:65596546 C/A cg26695010 chr11:65641043 EFEMP2 0.51 6.39 0.37 7.26e-10 Eosinophil percentage of white cells; CESC cis rs26528 0.584 rs153103 chr16:28528623 A/G cg07382826 chr16:28625726 SULT1A1 -0.33 -5.27 -0.31 2.82e-7 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.77 0.33 2.24e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg26343298 chr8:95960752 TP53INP1 0.36 5.93 0.34 9.41e-9 Type 2 diabetes; CESC cis rs1008375 0.931 rs6449326 chr4:17699790 G/T cg02297831 chr4:17616191 MED28 0.45 5.45 0.32 1.14e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg14820908 chr5:178986412 RUFY1 0.48 7.11 0.4 1.05e-11 Lung cancer; CESC cis rs62229266 0.804 rs2835259 chr21:37425302 T/C cg12218747 chr21:37451666 NA -0.42 -5.92 -0.34 9.9e-9 Mitral valve prolapse; CESC cis rs7178572 0.633 rs12907746 chr15:77843326 A/G cg22256960 chr15:77711686 NA -0.52 -6.35 -0.36 9.29e-10 Type 2 diabetes; CESC cis rs563538 1 rs563538 chr13:37433721 A/G cg23429638 chr13:37573626 EXOSC8;ALG5 -0.67 -5.09 -0.3 6.78e-7 Spontaneous preterm birth (preterm birth); CESC cis rs16854884 0.632 rs35629416 chr3:143748424 C/T cg06585982 chr3:143692056 C3orf58 0.49 6.14 0.35 2.96e-9 Economic and political preferences (feminism/equality); CESC cis rs9291683 0.609 rs36084205 chr4:10028678 A/C cg02734326 chr4:10020555 SLC2A9 0.47 6.52 0.37 3.47e-10 Bone mineral density; CESC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs910316 0.737 rs175065 chr14:75494983 T/C cg11812906 chr14:75593930 NEK9 -0.82 -13.3 -0.63 2.87e-31 Height; CESC cis rs7520050 0.931 rs11211224 chr1:46384388 G/A cg24296786 chr1:45957014 TESK2 0.44 5.48 0.32 9.94e-8 Red blood cell count;Reticulocyte count; CESC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg02564969 chr6:151773285 C6orf211;RMND1 0.6 8.23 0.45 8.68e-15 Menarche (age at onset); CESC cis rs28647808 0.748 rs28721280 chr9:136267318 C/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg08508325 chr11:3079039 CARS -0.58 -10.72 -0.55 1.6400000000000001e-22 Longevity; CESC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg26839252 chr6:160211577 TCP1;MRPL18 0.49 6.15 0.35 2.83e-9 Age-related macular degeneration (geographic atrophy); CESC cis rs2439831 0.850 rs28590651 chr15:44113016 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.65 7.54 0.42 7.27e-13 Lung cancer in ever smokers; CESC cis rs7927592 0.731 rs643609 chr11:68241833 A/G cg20283391 chr11:68216788 NA -0.47 -5.98 -0.34 7.13e-9 Total body bone mineral density; CESC cis rs7527798 0.592 rs2181694 chr1:207826776 G/A cg21110645 chr1:207815933 NA -0.34 -6.2 -0.36 2.1e-9 Erythrocyte sedimentation rate; CESC trans rs10463316 0.894 rs7723379 chr5:150765025 T/C cg24389359 chr12:111284228 CCDC63 -0.34 -6.08 -0.35 4.19e-9 Metabolite levels (Pyroglutamine); CESC cis rs2072499 0.833 rs2842870 chr1:156200671 T/C cg24450063 chr1:156163899 SLC25A44 0.87 13.93 0.65 1.74e-33 Testicular germ cell tumor; CESC trans rs116988415 0.748 rs12587471 chr14:65292315 A/G cg22747501 chr7:29233476 CHN2 0.51 6.16 0.35 2.75e-9 Daytime sleep phenotypes; CESC cis rs7824557 0.564 rs2572394 chr8:11235393 A/G cg21775007 chr8:11205619 TDH -0.54 -8.12 -0.45 1.75e-14 Retinal vascular caliber; CESC cis rs66573146 1.000 rs7686168 chr4:6986057 C/A cg00086871 chr4:6988644 TBC1D14 1.11 6.36 0.36 8.97e-10 Granulocyte percentage of myeloid white cells; CESC cis rs4704187 0.663 rs965735 chr5:74459220 A/G cg03227963 chr5:74354835 NA 0.29 5.32 0.31 2.25e-7 Response to amphetamines; CESC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg02725872 chr8:58115012 NA 0.44 6.68 0.38 1.36e-10 Developmental language disorder (linguistic errors); CESC cis rs2302190 0.882 rs6503859 chr17:56460852 C/G cg25885038 chr17:56607967 SEPT4 -0.4 -5.42 -0.32 1.37e-7 Vitamin D levels; CESC cis rs9303401 0.659 rs61291849 chr17:56909867 T/C cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.69 0.61 3.78e-29 Cognitive test performance; CESC cis rs7818688 0.697 rs74553842 chr8:95984392 C/T cg16049864 chr8:95962084 TP53INP1 0.55 5.56 0.32 6.66e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1559088 0.744 rs12462426 chr19:33536683 A/C cg22980127 chr19:33182716 NUDT19 0.47 5.32 0.31 2.18e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6901004 0.803 rs4947107 chr6:111442505 C/T cg15721981 chr6:111408429 SLC16A10 -0.34 -5.04 -0.3 8.59e-7 Blood metabolite levels; CESC cis rs116095464 0.558 rs10058428 chr5:235608 A/G cg22496380 chr5:211416 CCDC127 -0.75 -8.8 -0.48 1.82e-16 Breast cancer; CESC cis rs6032067 0.777 rs34343273 chr20:43795293 G/A cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs12142240 0.698 rs17357759 chr1:46832534 A/G cg00530320 chr1:46809349 NSUN4 0.57 7.8 0.43 1.4e-13 Menopause (age at onset); CESC cis rs3820928 0.874 rs13383070 chr2:227904939 C/T cg05526886 chr2:227700861 RHBDD1 -0.43 -5.66 -0.33 3.89e-8 Pulmonary function; CESC cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg02574844 chr11:5959923 NA -0.45 -5.63 -0.33 4.63e-8 DNA methylation (variation); CESC cis rs977987 0.778 rs11862719 chr16:75431708 T/A cg03315344 chr16:75512273 CHST6 0.4 5.71 0.33 3e-8 Dupuytren's disease; CESC trans rs801193 1.000 rs7783924 chr7:66209057 A/C cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC trans rs877282 0.898 rs12357016 chr10:765675 C/T cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg04414720 chr1:150670196 GOLPH3L 0.57 7.53 0.42 8.1e-13 Melanoma; CESC cis rs1006703 0.544 rs8068362 chr17:3838757 T/C cg06463185 chr17:3833770 ATP2A3 -0.64 -6.26 -0.36 1.58e-9 Glucose homeostasis traits; CESC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg04944784 chr2:26401820 FAM59B -0.63 -7.23 -0.41 5.29e-12 Gut microbiome composition (summer); CESC trans rs13360092 0.764 rs10213960 chr5:50561783 T/C cg03200537 chr16:87022121 NA 0.69 6.01 0.35 6.15e-9 Verbal declarative memory; CESC cis rs7605827 0.897 rs11693457 chr2:15612683 A/C cg19274914 chr2:15703543 NA 0.36 6.42 0.37 6.17e-10 Educational attainment (years of education); CESC cis rs2832191 1.000 rs2832191 chr21:30489300 A/C cg24692254 chr21:30365293 RNF160 -0.72 -10.88 -0.56 4.78e-23 Dental caries; CESC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg04772025 chr11:68637568 NA -0.5 -6.19 -0.36 2.23e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3820068 0.581 rs6693694 chr1:15980135 G/T cg17385448 chr1:15911702 AGMAT 0.42 6.89 0.39 4.17e-11 Systolic blood pressure; CESC cis rs644799 0.896 rs4430471 chr11:95646774 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.59 7.55 0.42 7.19e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs9354308 0.933 rs2814131 chr6:66562051 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 7.82 0.43 1.27e-13 Metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26221637 chr1:1510359 SSU72 -0.49 -6.3 -0.36 1.24e-9 Fibrinogen levels; CESC cis rs6540556 0.682 rs2282741 chr1:209900609 G/C cg05527609 chr1:210001259 C1orf107 -0.44 -5.28 -0.31 2.68e-7 Red blood cell count; CESC cis rs7208859 0.614 rs216412 chr17:28903394 A/G cg19761014 chr17:28927070 LRRC37B2 -0.75 -7.46 -0.42 1.28e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg18404041 chr3:52824283 ITIH1 -0.37 -6.54 -0.37 3.16e-10 Electroencephalogram traits; CESC cis rs2952156 0.959 rs907087 chr17:37828787 G/A cg00129232 chr17:37814104 STARD3 -0.74 -9.51 -0.5 1.25e-18 Asthma; CESC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.37 -0.31 1.76e-7 Life satisfaction; CESC cis rs9372253 0.934 rs9320327 chr6:110715194 T/A cg19196401 chr6:110721138 DDO -0.39 -5.63 -0.33 4.51e-8 Platelet distribution width; CESC cis rs826838 1.000 rs826888 chr12:39104719 C/G cg13010199 chr12:38710504 ALG10B -0.42 -5.86 -0.34 1.37e-8 Heart rate; CESC cis rs597539 0.727 rs632984 chr11:68620271 C/T cg01988459 chr11:68622903 NA -0.4 -5.12 -0.3 5.75e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg22143856 chr6:28129313 ZNF389 0.46 5.84 0.34 1.56e-8 Depression; CESC cis rs9467711 0.606 rs35307327 chr6:26370474 C/T cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs977987 0.806 rs11860284 chr16:75412907 A/G cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.78e-8 Dupuytren's disease; CESC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg22823121 chr1:150693482 HORMAD1 0.46 6.46 0.37 4.87e-10 Melanoma; CESC cis rs2479724 0.846 rs2488338 chr6:41808351 A/G cg17623882 chr6:41773611 USP49 -0.4 -5.75 -0.33 2.49e-8 Menarche (age at onset); CESC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg04267008 chr7:1944627 MAD1L1 -0.6 -7.23 -0.41 5.11e-12 Bipolar disorder and schizophrenia; CESC cis rs7267979 0.966 rs416745 chr20:25438868 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.57 0.73 2.33e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs2777491 1.000 rs7167729 chr15:41721042 G/A cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.78 -0.52 1.71e-19 Ulcerative colitis; CESC trans rs877282 1.000 rs11253366 chr10:773386 C/T cg22713356 chr15:30763199 NA 1.11 11.25 0.57 2.85e-24 Uric acid levels; CESC cis rs7481584 0.924 rs4758502 chr11:2998461 C/T cg25174290 chr11:3078921 CARS -0.51 -6.22 -0.36 1.95e-9 Calcium levels; CESC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg27588902 chr6:42928151 GNMT -0.31 -5.8 -0.34 1.85e-8 Alzheimer's disease in APOE e4+ carriers; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg25303336 chr6:33756862 LEMD2 0.46 6.0 0.35 6.49e-9 Weight; CESC trans rs561341 1.000 rs548957 chr17:30302411 G/A cg20587970 chr11:113659929 NA -1.41 -18.23 -0.75 1.08e-48 Hip circumference adjusted for BMI; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16809304 chr8:143784794 LY6K 0.39 6.04 0.35 5.07e-9 Fibrinogen levels; CESC cis rs7551222 0.681 rs4252686 chr1:204496895 A/G cg20240347 chr1:204465584 NA -0.28 -5.74 -0.33 2.59e-8 Schizophrenia; CESC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.47 -0.37 4.79e-10 Life satisfaction; CESC cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg20503657 chr10:835505 NA 0.77 7.72 0.43 2.36e-13 Eosinophil percentage of granulocytes; CESC cis rs2354432 0.556 rs12568866 chr1:146718430 A/C cg25205988 chr1:146714368 CHD1L -1.03 -8.98 -0.48 5.06e-17 Mitochondrial DNA levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06225581 chr5:140080094 ZMAT2 -0.56 -6.23 -0.36 1.87e-9 Gut microbiome composition (summer); CESC cis rs6121246 0.559 rs6060932 chr20:30350545 A/G cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg23803603 chr1:2058230 PRKCZ -0.37 -6.75 -0.38 9.46e-11 Height; CESC cis rs1256061 0.603 rs3020445 chr14:64788644 A/G cg23250157 chr14:64679961 SYNE2 0.53 7.39 0.41 1.96e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9611565 0.729 rs505533 chr22:41864216 A/C cg06481639 chr22:41940642 POLR3H 0.44 5.32 0.31 2.22e-7 Vitiligo; CESC cis rs7429990 0.965 rs184388 chr3:47939626 G/A cg11946769 chr3:48343235 NME6 0.46 5.62 0.33 4.91e-8 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03163734 chr2:65659863 SPRED2 0.56 6.02 0.35 5.64e-9 Gut microbiome composition (summer); CESC cis rs9814567 0.752 rs4605591 chr3:134328361 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.39 -5.04 -0.3 8.59e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg19592336 chr6:28129416 ZNF389 -0.49 -6.77 -0.38 8.47e-11 Depression; CESC cis rs7598759 0.712 rs6740474 chr2:232331831 A/G cg19187155 chr2:232395269 NMUR1 0.39 6.12 0.35 3.36e-9 Noise-induced hearing loss; CESC cis rs113835537 0.627 rs11227534 chr11:66336171 C/A cg24851651 chr11:66362959 CCS 0.5 5.95 0.34 8.35e-9 Airway imaging phenotypes; CESC cis rs870825 0.616 rs7658186 chr4:185622509 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs734999 0.588 rs6689711 chr1:2531467 T/C cg18854424 chr1:2615690 NA -0.27 -5.14 -0.3 5.24e-7 Ulcerative colitis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07399312 chr1:156470683 MEF2D 0.47 6.2 0.36 2.16e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs68170813 0.559 rs3801963 chr7:106898036 C/T cg02696742 chr7:106810147 HBP1 -0.53 -5.34 -0.31 2.01e-7 Coronary artery disease; CESC cis rs3026445 0.851 rs34840178 chr12:110832027 A/G cg12870014 chr12:110450643 ANKRD13A 0.42 5.18 0.3 4.33e-7 QT interval; CESC cis rs8062405 1.000 rs12325113 chr16:28848668 T/C cg08761264 chr16:28874980 SH2B1 -0.44 -5.45 -0.32 1.16e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6545883 0.929 rs55806663 chr2:61740487 G/T cg15711740 chr2:61764176 XPO1 -0.43 -5.3 -0.31 2.41e-7 Tuberculosis; CESC cis rs938554 0.513 rs4529048 chr4:9997112 G/T cg02734326 chr4:10020555 SLC2A9 0.43 5.29 0.31 2.58e-7 Blood metabolite levels; CESC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg20999797 chr1:1681921 NA 0.26 5.11 0.3 6.15e-7 Body mass index; CESC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.79 0.43 1.5e-13 Prudent dietary pattern; CESC cis rs7259376 0.871 rs2360622 chr19:22570622 T/C cg02657401 chr19:22469223 NA -0.25 -5.1 -0.3 6.58e-7 Menopause (age at onset); CESC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg08859206 chr1:53392774 SCP2 0.54 7.11 0.4 1.05e-11 Monocyte count; CESC cis rs2072732 0.861 rs12409277 chr1:2957600 A/G cg15211996 chr1:2936768 ACTRT2 0.34 6.25 0.36 1.64e-9 Plateletcrit; CESC cis rs6087990 0.871 rs1007122 chr20:31346001 C/T cg13636640 chr20:31349939 DNMT3B 0.79 12.8 0.62 1.58e-29 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11488864 chr4:8379238 ACOX3 -0.56 -6.38 -0.36 7.86e-10 Gut microbiome composition (summer); CESC cis rs17253792 0.598 rs35830444 chr14:56017350 T/C cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs7647973 1.000 rs9860055 chr3:49506900 C/T cg02487422 chr3:49467188 NICN1 -0.41 -5.36 -0.31 1.81e-7 Menarche (age at onset); CESC cis rs6667605 0.527 rs12046118 chr1:2540343 A/C cg20673091 chr1:2541236 MMEL1 0.45 7.84 0.43 1.09e-13 Inflammatory bowel disease;Ulcerative colitis; CESC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg15112475 chr7:1198522 ZFAND2A -0.36 -5.75 -0.33 2.45e-8 Longevity;Endometriosis; CESC cis rs3020736 0.500 rs6002603 chr22:42492362 C/G cg04733989 chr22:42467013 NAGA -0.82 -12.02 -0.59 7.23e-27 Autism spectrum disorder or schizophrenia; CESC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg12756686 chr19:29218302 NA 0.58 7.52 0.42 8.38e-13 Methadone dose in opioid dependence; CESC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg17427002 chr7:12443146 VWDE -0.55 -6.79 -0.38 7.54e-11 Coronary artery disease; CESC trans rs875971 1.000 rs778710 chr7:65854834 T/C cg26939375 chr7:64535504 NA 0.47 6.14 0.35 3.07e-9 Aortic root size; CESC cis rs1451375 0.583 rs3779078 chr7:50610918 C/T cg14593290 chr7:50529359 DDC 0.51 6.19 0.36 2.34e-9 Malaria; CESC cis rs35306767 0.953 rs12259801 chr10:959306 C/G cg10556349 chr10:835070 NA 0.57 6.07 0.35 4.29e-9 Eosinophil percentage of granulocytes; CESC cis rs2361710 0.611 rs3816257 chr17:78074446 G/T cg06718696 chr17:78121285 EIF4A3 -0.62 -7.51 -0.42 9.34e-13 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CESC cis rs7712401 0.601 rs246271 chr5:122212822 A/G cg19412675 chr5:122181750 SNX24 0.41 5.1 0.3 6.57e-7 Mean platelet volume; CESC cis rs3818285 0.556 rs3758409 chr10:111669239 A/C cg00817464 chr10:111662876 XPNPEP1 -0.54 -6.69 -0.38 1.33e-10 Superior crus of antihelix expression; CESC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg07952391 chr2:88470173 THNSL2 -0.61 -5.79 -0.34 2e-8 Plasma clusterin levels; CESC cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.42 0.32 1.32e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs1801251 1.000 rs2100053 chr2:233719516 G/T cg25237894 chr2:233734115 C2orf82 -0.48 -8.29 -0.45 5.66e-15 Coronary artery disease; CESC cis rs7916697 0.578 rs1900002 chr10:70004552 G/C cg06988349 chr10:69991859 ATOH7 0.39 6.39 0.37 7.5e-10 Optic disc area; CESC cis rs67311347 1.000 rs4974017 chr3:40473519 C/T cg09455208 chr3:40491958 NA 0.46 8.04 0.44 2.96e-14 Renal cell carcinoma; CESC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg15921436 chr17:44337874 NA -0.44 -5.58 -0.32 6e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27308231 chr10:94050819 CPEB3;MARCH5 -0.46 -6.51 -0.37 3.68e-10 Gambling; CESC cis rs17209837 0.607 rs1473154 chr7:87082042 A/G cg00919237 chr7:87102261 ABCB4 -0.51 -6.61 -0.38 2.1e-10 Gallbladder cancer; CESC trans rs801193 1.000 rs17566701 chr7:66193183 T/C cg26939375 chr7:64535504 NA 0.62 8.21 0.45 9.49e-15 Aortic root size; CESC cis rs2439831 1.000 rs7173487 chr15:43750239 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.84 8.59 0.47 7.37e-16 Lung cancer in ever smokers; CESC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg25405998 chr7:65216604 CCT6P1 -0.44 -5.67 -0.33 3.7e-8 Calcium levels; CESC cis rs7582720 1.000 rs6738618 chr2:203749439 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg19539972 chr4:7069911 GRPEL1 0.78 9.93 0.52 5.95e-20 Monocyte percentage of white cells; CESC cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.66 -8.92 -0.48 7.61e-17 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7772486 0.701 rs2244308 chr6:146213706 C/T cg05347473 chr6:146136440 FBXO30 0.53 6.92 0.39 3.46e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs7943203 1.000 rs11212638 chr11:108312080 T/C cg24643211 chr18:11851603 GNAL;CHMP1B -0.48 -6.04 -0.35 5.27e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs2880765 0.835 rs7169632 chr15:86044667 T/G cg10818794 chr15:86012489 AKAP13 -0.34 -5.22 -0.31 3.68e-7 Coronary artery disease; CESC cis rs3767633 0.748 rs6667896 chr1:161837407 G/A cg09175582 chr1:161736000 ATF6 0.86 6.98 0.39 2.42e-11 IgG glycosylation; CESC cis rs7474896 0.583 rs12776092 chr10:38015795 G/C cg00409905 chr10:38381863 ZNF37A -0.49 -5.6 -0.33 5.42e-8 Obesity (extreme); CESC cis rs8050907 0.744 rs13330957 chr16:4525330 G/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg21775979 chr11:780331 NA 0.41 6.19 0.36 2.23e-9 Breast cancer; CESC cis rs6540556 0.678 rs12094117 chr1:209888435 G/T cg05527609 chr1:210001259 C1orf107 -0.7 -7.5 -0.42 9.83e-13 Red blood cell count; CESC cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg03806693 chr22:41940476 POLR3H -1.19 -14.62 -0.67 6.9e-36 Vitiligo; CESC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.4 -0.31 1.48e-7 Lung cancer; CESC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.53 6.35 0.36 9.55e-10 Breast cancer; CESC cis rs10779751 0.734 rs1211575 chr1:11118390 G/A cg08854313 chr1:11322531 MTOR 0.77 10.46 0.54 1.17e-21 Body mass index; CESC cis rs7799006 0.929 rs6951493 chr7:2257612 G/A cg08027265 chr7:2291960 NA -0.45 -6.8 -0.39 6.97e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs250677 0.522 rs10040598 chr5:148365720 C/A cg18129178 chr5:148520854 ABLIM3 0.47 5.16 0.3 4.93e-7 Breast cancer; CESC cis rs7267979 1.000 rs6083805 chr20:25317356 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -16.91 -0.72 5.15e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg11494091 chr17:61959527 GH2 0.76 13.48 0.64 6.83e-32 Prudent dietary pattern; CESC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs3820928 1.000 rs1835158 chr2:227763993 C/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.77 -0.33 2.2e-8 Pulmonary function; CESC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg26119090 chr2:26468346 HADHA;HADHB 0.61 7.09 0.4 1.24e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18202751 chr17:7620996 NA 0.6 6.7 0.38 1.24e-10 Gut microbiome composition (summer); CESC cis rs2795502 0.873 rs1891324 chr10:43399581 A/G cg20628663 chr10:43360327 NA 0.54 6.08 0.35 4.28e-9 Blood protein levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13969496 chr9:140095465 C9orf75 -0.4 -6.65 -0.38 1.68e-10 Gambling; CESC trans rs5769765 0.908 rs9616370 chr22:50306316 A/G cg09872104 chr7:134855509 C7orf49 0.54 6.08 0.35 4.13e-9 Schizophrenia; CESC cis rs250677 0.617 rs166106 chr5:148447061 T/C cg18129178 chr5:148520854 ABLIM3 -0.6 -6.05 -0.35 4.91e-9 Breast cancer; CESC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -7.38 -0.41 2.06e-12 Developmental language disorder (linguistic errors); CESC cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.77 7.24 0.41 4.88e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs79976124 1.000 rs79976124 chr6:66618657 G/A cg07460842 chr6:66804631 NA 0.75 8.54 0.46 1.06e-15 Type 2 diabetes; CESC cis rs7188697 0.922 rs37034 chr16:58551360 C/G cg02549819 chr16:58548995 SETD6 -0.41 -5.03 -0.3 9.12e-7 QT interval; CESC cis rs36051895 0.623 rs3780382 chr9:5232299 G/A cg02405213 chr9:5042618 JAK2 -0.49 -5.81 -0.34 1.8e-8 Pediatric autoimmune diseases; CESC cis rs2304069 0.909 rs2544931 chr5:149367837 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.92 -11.14 -0.56 6.85e-24 HIV-1 control; CESC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg23758822 chr17:41437982 NA 1.03 14.6 0.67 7.88e-36 Menopause (age at onset); CESC cis rs7937682 0.924 rs10891288 chr11:111552053 G/T cg22437258 chr11:111473054 SIK2 -0.67 -8.95 -0.48 6.43e-17 Primary sclerosing cholangitis; CESC cis rs6987853 0.787 rs2974314 chr8:42457043 C/T cg09913449 chr8:42400586 C8orf40 0.42 6.98 0.39 2.38e-11 Mean corpuscular hemoglobin concentration; CESC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg04369109 chr6:150039330 LATS1 -0.45 -6.39 -0.37 7.48e-10 Lung cancer; CESC cis rs4481887 0.927 rs7519334 chr1:248472076 C/T cg00666640 chr1:248458726 OR2T12 0.35 5.81 0.34 1.81e-8 Common traits (Other); CESC cis rs2014572 0.967 rs10421632 chr19:57764770 G/A cg12963866 chr19:57752005 ZNF805 -0.48 -6.47 -0.37 4.61e-10 Hyperactive-impulsive symptoms; CESC cis rs10751667 0.666 rs7395488 chr11:954111 T/C cg01483505 chr11:975446 AP2A2 0.37 5.05 0.3 8.3e-7 Alzheimer's disease (late onset); CESC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC trans rs61931739 0.736 rs7314457 chr12:34454301 G/A cg26384229 chr12:38710491 ALG10B 0.67 10.45 0.54 1.29e-21 Morning vs. evening chronotype; CESC trans rs7618501 1.000 rs7374183 chr3:49785133 G/A cg21659725 chr3:3221576 CRBN -0.83 -13.42 -0.64 1.08e-31 Intelligence (multi-trait analysis); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg15159625 chr1:118042759 MAN1A2 0.41 6.41 0.37 6.68e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs12200560 0.505 rs211172 chr6:97070691 C/A cg06623918 chr6:96969491 KIAA0776 0.46 5.75 0.33 2.48e-8 Coronary heart disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06838422 chr1:62902269 USP1 0.52 7.19 0.4 6.49e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs16867321 0.853 rs73023563 chr2:181502830 C/T cg23363182 chr2:181467187 NA -0.41 -5.53 -0.32 7.58e-8 Obesity; CESC cis rs854765 0.583 rs4414547 chr17:17859052 G/T cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.27e-16 Colonoscopy-negative controls vs population controls; CESC cis rs3733585 0.673 rs4495037 chr4:9954050 C/G cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg15921436 chr17:44337874 NA -0.44 -5.64 -0.33 4.41e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg18876405 chr7:65276391 NA 0.55 7.52 0.42 8.43e-13 Aortic root size; CESC cis rs7829975 0.774 rs11775523 chr8:8679176 A/G cg15556689 chr8:8085844 FLJ10661 0.45 5.69 0.33 3.44e-8 Mood instability; CESC cis rs9787249 0.957 rs11809515 chr1:40205326 C/A cg02773041 chr1:40204384 PPIE 0.54 7.69 0.43 2.82e-13 Blood protein levels; CESC cis rs7851660 0.874 rs10818175 chr9:100633386 T/C cg13688889 chr9:100608707 NA -0.6 -8.55 -0.47 9.84e-16 Strep throat; CESC cis rs3733585 0.638 rs17185835 chr4:9958180 T/G cg02734326 chr4:10020555 SLC2A9 -0.43 -5.93 -0.34 9.22e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9911578 0.967 rs12938821 chr17:56959422 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -6.74 -0.38 9.58e-11 Intelligence (multi-trait analysis); CESC cis rs7828089 0.582 rs13259873 chr8:22266292 C/T cg13512537 chr8:22265999 SLC39A14 -0.36 -5.1 -0.3 6.53e-7 Verbal declarative memory; CESC cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg09555818 chr19:45449301 APOC2 0.39 6.26 0.36 1.55e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg08499158 chr17:42289980 UBTF -0.47 -5.74 -0.33 2.53e-8 Total body bone mineral density; CESC cis rs921968 0.643 rs497983 chr2:219415189 A/G cg02176678 chr2:219576539 TTLL4 0.4 6.94 0.39 2.93e-11 Mean corpuscular hemoglobin concentration; CESC cis rs1401999 0.966 rs2313216 chr3:183637251 C/T cg01324343 chr3:183735012 ABCC5 0.57 11.6 0.58 2e-25 Anterior chamber depth; CESC cis rs12586317 0.883 rs4982254 chr14:35755737 C/T cg16230307 chr14:35515116 FAM177A1 0.73 8.33 0.46 4.34e-15 Psoriasis; CESC cis rs7617773 0.539 rs11706939 chr3:48383992 G/T cg11946769 chr3:48343235 NME6 0.66 8.34 0.46 4.12e-15 Coronary artery disease; CESC cis rs9300255 0.510 rs1790133 chr12:123698518 T/G cg05973401 chr12:123451056 ABCB9 0.51 5.78 0.33 2.07e-8 Neutrophil percentage of white cells; CESC cis rs9900062 0.586 rs35018407 chr17:62690181 A/C cg02097616 chr17:62675921 NA 0.44 5.56 0.32 6.65e-8 QT interval; CESC trans rs17685 0.697 rs2302437 chr7:75677016 G/A cg19862616 chr7:65841803 NCRNA00174 -0.84 -12.47 -0.61 2.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC trans rs7395662 0.611 rs7478698 chr11:48549139 T/C cg00717180 chr2:96193071 NA -0.44 -6.06 -0.35 4.58e-9 HDL cholesterol; CESC cis rs910316 0.737 rs175043 chr14:75471803 G/A cg16144293 chr14:75469539 EIF2B2 0.4 5.18 0.3 4.45e-7 Height; CESC cis rs2760061 0.626 rs594916 chr1:228133544 C/A cg01973587 chr1:228161476 NA 0.38 5.84 0.34 1.55e-8 Diastolic blood pressure; CESC cis rs847577 0.630 rs11764933 chr7:97825188 G/A cg21770322 chr7:97807741 LMTK2 0.86 14.68 0.67 4.05e-36 Breast cancer; CESC cis rs6748734 0.625 rs4312490 chr2:241821481 A/G cg04034577 chr2:241836375 C2orf54 -0.31 -5.65 -0.33 4.16e-8 Urinary metabolites; CESC cis rs1008375 1.000 rs4698199 chr4:17656738 G/C cg02297831 chr4:17616191 MED28 0.53 6.71 0.38 1.2e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7851660 0.844 rs993501 chr9:100623377 A/G cg13688889 chr9:100608707 NA 0.64 8.95 0.48 6.59e-17 Strep throat; CESC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg22800045 chr5:56110881 MAP3K1 0.81 9.66 0.51 4.1e-19 Initial pursuit acceleration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06854353 chr6:109704291 CD164 0.45 6.15 0.35 2.79e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9581857 0.556 rs1885991 chr13:28040470 G/A cg01674679 chr13:27998804 GTF3A -0.55 -5.89 -0.34 1.17e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs9403521 1.000 rs117303301 chr6:143999003 C/T cg18240653 chr6:144019428 PHACTR2 -0.48 -5.36 -0.31 1.81e-7 Obesity-related traits; CESC cis rs12188164 0.620 rs1043356 chr5:480948 C/T cg15813090 chr5:442598 EXOC3;C5orf55 -0.39 -5.47 -0.32 1.02e-7 Cystic fibrosis severity; CESC cis rs4843747 0.671 rs28451517 chr16:88109127 A/C cg17633681 chr16:88106987 BANP 0.72 9.39 0.5 2.8e-18 Menopause (age at onset); CESC cis rs933688 1.000 rs10058025 chr5:90689052 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 12.36 0.6 5.17e-28 Smoking behavior; CESC cis rs9815354 0.680 rs73073288 chr3:42027637 G/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08236912 chr17:37557587 FBXL20 -0.57 -6.09 -0.35 3.88e-9 Gut microbiome composition (summer); CESC cis rs2235649 0.843 rs9932890 chr16:1847868 G/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 0.41 5.12 0.3 5.97e-7 Blood metabolite levels; CESC cis rs2415984 0.622 rs7156466 chr14:46933384 A/G cg14871534 chr14:47121158 RPL10L -0.34 -5.12 -0.3 5.96e-7 Number of children ever born; CESC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg22105103 chr4:187893119 NA 0.38 5.73 0.33 2.78e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs858239 0.601 rs73272053 chr7:23155525 A/G cg23682824 chr7:23144976 KLHL7 0.46 6.1 0.35 3.83e-9 Cerebrospinal fluid biomarker levels; CESC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.91 9.96 0.52 4.74e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.45 6.0 0.35 6.42e-9 Lymphocyte counts; CESC cis rs75477785 0.590 rs1040424 chr1:210134382 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.84 6.29 0.36 1.29e-9 Cleft lip with or without cleft palate; CESC cis rs7267979 0.586 rs11087505 chr20:25196520 T/A cg08601574 chr20:25228251 PYGB 0.36 5.1 0.3 6.43e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7916697 0.626 rs3858145 chr10:70011838 A/G cg06988349 chr10:69991859 ATOH7 0.31 5.03 0.3 9.05e-7 Optic disc area; CESC cis rs9329289 0.510 rs10903785 chr10:2550063 C/T cg15501526 chr10:2543763 NA 0.48 7.86 0.43 9.74e-14 Age-related hearing impairment; CESC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 10.98 0.56 2.37e-23 Platelet count; CESC cis rs950169 0.922 rs11633534 chr15:85124642 C/T cg17507749 chr15:85114479 UBE2QP1 0.54 6.09 0.35 3.99e-9 Schizophrenia; CESC cis rs2243480 1.000 rs2533288 chr7:66056711 C/G cg13147721 chr7:65941812 NA -0.93 -8.79 -0.47 1.98e-16 Diabetic kidney disease; CESC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg03188948 chr7:1209495 NA 0.72 6.93 0.39 3.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05407778 chr3:127399268 ABTB1 -0.54 -6.05 -0.35 4.98e-9 Gut microbiome composition (summer); CESC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.59 -0.38 2.43e-10 Life satisfaction; CESC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg21251018 chr6:28226885 NKAPL 0.34 5.53 0.32 7.72e-8 Cardiac Troponin-T levels; CESC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg27297192 chr10:134578999 INPP5A 0.39 5.12 0.3 5.95e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1020064 0.895 rs2250659 chr2:105889684 A/G cg02079111 chr2:105885981 TGFBRAP1 0.5 6.52 0.37 3.61e-10 AIDS; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg25971741 chr6:15343116 JARID2 -0.48 -6.41 -0.37 6.61e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs4481887 0.893 rs4512685 chr1:248446246 C/T cg00666640 chr1:248458726 OR2T12 0.37 6.47 0.37 4.71e-10 Common traits (Other); CESC cis rs1348850 0.914 rs2121430 chr2:178318375 A/G cg23306229 chr2:178417860 TTC30B 0.54 6.82 0.39 6.02e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7809950 0.773 rs2237668 chr7:107050209 A/G cg23024343 chr7:107201750 COG5 -0.59 -7.45 -0.42 1.35e-12 Coronary artery disease; CESC cis rs2228479 0.867 rs12930606 chr16:89946682 A/G cg00800038 chr16:89945340 TCF25 -0.88 -7.85 -0.43 1.01e-13 Skin colour saturation; CESC cis rs11958404 0.860 rs11135023 chr5:157420082 G/T cg05962755 chr5:157440814 NA 0.54 6.71 0.38 1.18e-10 IgG glycosylation; CESC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.21 -0.53 7.17e-21 Alzheimer's disease; CESC cis rs9549367 0.569 rs3024719 chr13:113814225 G/A cg00898013 chr13:113819073 PROZ -0.53 -6.62 -0.38 1.97e-10 Platelet distribution width; CESC trans rs877282 0.947 rs957642 chr10:773966 C/T cg22713356 chr15:30763199 NA 1.08 10.78 0.55 1.04e-22 Uric acid levels; CESC cis rs12410462 1.000 rs12410462 chr1:227667790 A/G cg23173402 chr1:227635558 NA -0.6 -6.08 -0.35 4.26e-9 Major depressive disorder; CESC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg18446336 chr7:2847575 GNA12 -0.4 -5.94 -0.34 8.91e-9 Height; CESC cis rs2952156 0.959 rs1565922 chr17:37831035 A/G cg00129232 chr17:37814104 STARD3 -0.71 -9.62 -0.51 5.48e-19 Asthma; CESC cis rs7216064 0.906 rs78452260 chr17:65848522 G/T cg07042672 chr17:66097459 LOC651250 -0.5 -5.13 -0.3 5.53e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2243480 1.000 rs4718269 chr7:65200778 C/G cg13147721 chr7:65941812 NA 0.86 8.14 0.45 1.51e-14 Diabetic kidney disease; CESC cis rs7267979 0.966 rs6083818 chr20:25346082 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.07 -0.74 3.95e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs3741151 0.656 rs10501411 chr11:73292085 A/C cg17517138 chr11:73019481 ARHGEF17 0.77 6.25 0.36 1.65e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs17253792 0.822 rs76192881 chr14:56034654 C/T cg01858014 chr14:56050164 KTN1 -0.94 -6.82 -0.39 6.11e-11 Putamen volume; CESC cis rs1355223 0.902 rs704744 chr11:34736561 A/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.44 -0.37 5.45e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.55 0.42 6.86e-13 Prudent dietary pattern; CESC cis rs9303401 0.614 rs34058624 chr17:57118121 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.86 10.68 0.55 2.3e-22 Cognitive test performance; CESC cis rs1538970 0.924 rs7528573 chr1:45913860 T/C cg06784218 chr1:46089804 CCDC17 0.35 5.54 0.32 7.26e-8 Platelet count; CESC cis rs4660261 0.561 rs11210934 chr1:44369435 G/A cg13606994 chr1:44402422 ARTN -0.38 -5.96 -0.34 7.9e-9 Intelligence (multi-trait analysis); CESC cis rs17253792 0.822 rs75351812 chr14:56082192 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs4835473 0.932 rs10025527 chr4:144889544 C/G cg25736465 chr4:144833511 NA 0.38 5.82 0.34 1.7e-8 Immature fraction of reticulocytes; CESC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg17143192 chr8:8559678 CLDN23 0.75 8.9 0.48 8.72e-17 Obesity-related traits; CESC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg03188948 chr7:1209495 NA 0.72 6.93 0.39 3.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4889855 0.556 rs56873925 chr17:78536611 C/T cg16591659 chr17:78472290 NA 0.39 6.42 0.37 6.35e-10 Fractional excretion of uric acid; CESC cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg24308560 chr3:49941425 MST1R -0.63 -9.02 -0.48 3.95e-17 Intelligence (multi-trait analysis); CESC cis rs6429082 0.783 rs291364 chr1:235687179 A/G cg26050004 chr1:235667680 B3GALNT2 0.66 8.77 0.47 2.23e-16 Adiposity; CESC cis rs4253772 0.678 rs1055659 chr22:46638298 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.54 5.65 0.33 4.08e-8 LDL cholesterol;Cholesterol, total; CESC cis rs854765 0.547 rs4072739 chr17:17884660 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.48 6.76 0.38 9.02e-11 Total body bone mineral density; CESC trans rs561341 0.882 rs2521594 chr17:30302087 C/T cg27661571 chr11:113659931 NA -0.83 -7.76 -0.43 1.9e-13 Hip circumference adjusted for BMI; CESC cis rs6502050 0.835 rs11654584 chr17:80079435 A/T cg11859384 chr17:80120422 CCDC57 -0.4 -5.39 -0.31 1.59e-7 Life satisfaction; CESC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg21770322 chr7:97807741 LMTK2 0.55 8.18 0.45 1.17e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs9300255 0.602 rs1716167 chr12:123651162 C/T cg00376283 chr12:123451042 ABCB9 -0.7 -8.72 -0.47 3.04e-16 Neutrophil percentage of white cells; CESC trans rs709082 0.709 rs709105 chr3:191471655 C/T cg25305879 chr2:106814630 NA 0.4 6.44 0.37 5.56e-10 Colonoscopy-negative controls vs population controls; CESC cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg10351095 chr21:47802916 PCNT -0.49 -6.62 -0.38 2.02e-10 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg03676636 chr4:99064102 C4orf37 0.33 5.05 0.3 8.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4595586 0.525 rs12818844 chr12:39423806 A/G cg26384229 chr12:38710491 ALG10B 0.6 8.2 0.45 1.03e-14 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg17366294 chr4:99064904 C4orf37 0.63 8.76 0.47 2.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.552 rs6502624 chr17:17847936 G/A cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC trans rs853679 0.556 rs13200214 chr6:28017250 C/T cg06606381 chr12:133084897 FBRSL1 -1.14 -8.21 -0.45 9.47e-15 Depression; CESC cis rs2594989 0.887 rs2447604 chr3:11574297 G/A cg00170343 chr3:11313890 ATG7 -0.63 -5.22 -0.31 3.66e-7 Circulating chemerin levels; CESC trans rs116095464 0.558 rs10036253 chr5:238519 A/C cg00938859 chr5:1591904 SDHAP3 0.64 6.99 0.39 2.27e-11 Breast cancer; CESC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg17178900 chr1:205818956 PM20D1 0.5 7.44 0.42 1.4e-12 Menarche (age at onset); CESC trans rs116095464 0.558 rs6869925 chr5:264036 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.38e-11 Breast cancer; CESC cis rs258892 0.895 rs10039408 chr5:72069110 G/T cg21869765 chr5:72125136 TNPO1 -0.43 -5.35 -0.31 1.93e-7 Small cell lung carcinoma; CESC cis rs3762637 1.000 rs13321097 chr3:122162007 C/T cg24169773 chr3:122142474 KPNA1 -0.54 -6.31 -0.36 1.2e-9 LDL cholesterol levels; CESC cis rs9926296 0.744 rs164746 chr16:89709019 C/T cg08949735 chr16:89699720 DPEP1 -0.28 -5.06 -0.3 7.68e-7 Vitiligo; CESC cis rs4975616 0.869 rs465498 chr5:1325803 A/G cg06550200 chr5:1325588 CLPTM1L -0.69 -11.07 -0.56 1.16e-23 Lung cancer; CESC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.51 -0.32 8.45e-8 Aortic root size; CESC cis rs5769765 0.955 rs8135963 chr22:50301476 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.49 -5.53 -0.32 7.82e-8 Schizophrenia; CESC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg07308232 chr7:1071921 C7orf50 -0.41 -5.59 -0.32 5.67e-8 Longevity;Endometriosis; CESC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 6.43 0.37 6.01e-10 Bipolar disorder; CESC cis rs8067354 0.645 rs1874548 chr17:57841357 A/G cg02344993 chr17:57696989 CLTC 0.57 5.97 0.34 7.53e-9 Hemoglobin concentration; CESC cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.32 0.6 7.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.53 -7.24 -0.41 4.87e-12 Menarche (age at onset); CESC cis rs2050392 0.894 rs303430 chr10:30706235 C/A cg18806716 chr10:30721971 MAP3K8 -0.43 -6.14 -0.35 3.01e-9 Inflammatory bowel disease; CESC cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg05347473 chr6:146136440 FBXO30 0.52 6.73 0.38 1.06e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs7335046 1.000 rs9517678 chr13:99961059 T/C cg14259717 chr11:18433732 LDHC 0.61 6.02 0.35 5.87e-9 Basal cell carcinoma; CESC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.56 7.42 0.41 1.55e-12 Lymphocyte counts; CESC cis rs6089584 1.000 rs6142910 chr20:60562181 C/A cg06108461 chr20:60628389 TAF4 -0.78 -11.36 -0.57 1.25e-24 Body mass index; CESC cis rs9858542 1.000 rs9822268 chr3:49719729 G/A cg03060546 chr3:49711283 APEH -0.58 -6.87 -0.39 4.44e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg00750074 chr16:89608354 SPG7 -0.35 -5.06 -0.3 7.86e-7 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08568561 chr7:42834498 NA -0.56 -6.11 -0.35 3.6e-9 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04381741 chr7:108210905 THAP5;DNAJB9 -0.48 -6.84 -0.39 5.4e-11 Gut microbiota (bacterial taxa); CESC cis rs6991838 0.612 rs12335276 chr8:66531903 A/G cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs477692 0.792 rs12762024 chr10:131441055 G/C cg05714579 chr10:131428358 MGMT -0.57 -8.2 -0.45 1.08e-14 Response to temozolomide; CESC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.55 8.22 0.45 9.26e-15 Bipolar disorder; CESC cis rs9911578 1.000 rs8071280 chr17:57010225 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -6.81 -0.39 6.39e-11 Intelligence (multi-trait analysis); CESC cis rs6137287 0.643 rs6047261 chr20:21103910 T/G cg13880779 chr20:21376337 NKX2-4 0.33 5.31 0.31 2.33e-7 Height; CESC cis rs9902453 1.000 rs6505152 chr17:28331466 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.83 -0.43 1.15e-13 Coffee consumption (cups per day); CESC cis rs3772130 0.564 rs28620947 chr3:121585631 G/A cg20356878 chr3:121714668 ILDR1 0.44 6.31 0.36 1.18e-9 Cognitive performance; CESC cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg07636037 chr3:49044803 WDR6 1.02 18.44 0.75 2.06e-49 Parkinson's disease; CESC cis rs8077577 0.708 rs3889544 chr17:18133788 C/T cg16794390 chr17:18148240 FLII -0.45 -6.69 -0.38 1.35e-10 Obesity-related traits; CESC cis rs4803468 1.000 rs11670668 chr19:41920454 G/C cg09537434 chr19:41945824 ATP5SL -1.08 -18.9 -0.76 4.86e-51 Height; CESC cis rs1448094 0.511 rs17279289 chr12:86162792 T/G cg00310523 chr12:86230176 RASSF9 0.35 5.59 0.32 5.75e-8 Major depressive disorder; CESC cis rs8078723 1.000 rs709592 chr17:38175553 C/T cg17467752 chr17:38218738 THRA 0.66 9.91 0.52 6.68e-20 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs2486288 0.656 rs1706768 chr15:45569443 T/C cg09092052 chr15:45571596 NA 0.51 6.0 0.35 6.6e-9 Glomerular filtration rate; CESC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.74 7.57 0.42 6.21e-13 Platelet count; CESC cis rs6991838 0.584 rs7012856 chr8:66534975 C/T cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs798554 0.704 rs798503 chr7:2789704 G/A cg19717773 chr7:2847554 GNA12 -0.56 -8.8 -0.48 1.81e-16 Height; CESC cis rs9309473 0.950 rs6705977 chr2:73849170 C/G cg20560298 chr2:73613845 ALMS1 -0.45 -5.89 -0.34 1.17e-8 Metabolite levels; CESC cis rs2228479 0.717 rs1061647 chr16:89806063 G/C cg00800038 chr16:89945340 TCF25 -0.83 -6.65 -0.38 1.71e-10 Skin colour saturation; CESC cis rs2985684 0.894 rs4900932 chr14:50022928 A/G cg04989706 chr14:50066350 PPIL5 -0.45 -5.17 -0.3 4.58e-7 Carotid intima media thickness; CESC cis rs7605827 0.930 rs2287635 chr2:15704410 C/G cg19274914 chr2:15703543 NA 0.3 5.44 0.32 1.21e-7 Educational attainment (years of education); CESC cis rs8114671 0.836 rs2425006 chr20:33571228 T/G cg07148914 chr20:33460835 GGT7 -0.43 -5.51 -0.32 8.28e-8 Height; CESC cis rs17376456 0.825 rs17314762 chr5:93231200 C/T cg25358565 chr5:93447407 FAM172A 1.13 10.46 0.54 1.15e-21 Diabetic retinopathy; CESC cis rs12410462 0.681 rs4486420 chr1:227572321 T/A cg23173402 chr1:227635558 NA 0.68 5.73 0.33 2.78e-8 Major depressive disorder; CESC cis rs17376456 0.877 rs7736620 chr5:93305762 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.64 5.63 0.33 4.56e-8 Diabetic retinopathy; CESC cis rs4566357 0.615 rs10174591 chr2:227913140 G/A cg05526886 chr2:227700861 RHBDD1 -0.47 -6.27 -0.36 1.45e-9 Coronary artery disease; CESC cis rs6088590 0.930 rs6120723 chr20:33364655 C/T cg08999081 chr20:33150536 PIGU 0.59 9.06 0.49 2.93e-17 Coronary artery disease; CESC cis rs9790314 0.605 rs2593812 chr3:160703069 T/G cg04691961 chr3:161091175 C3orf57 0.38 5.04 0.3 8.69e-7 Morning vs. evening chronotype; CESC cis rs10129255 0.500 rs10142931 chr14:107190525 A/C cg07958169 chr14:107095056 NA -0.58 -9.32 -0.5 4.62e-18 Kawasaki disease; CESC cis rs9467711 0.790 rs13195402 chr6:26463575 G/T cg14345882 chr6:26364793 BTN3A2 0.63 5.15 0.3 4.99e-7 Autism spectrum disorder or schizophrenia; CESC cis rs1707322 0.964 rs785508 chr1:46527159 G/A cg03146154 chr1:46216737 IPP -0.7 -9.16 -0.49 1.46e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7208859 0.623 rs28627615 chr17:29145817 G/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6752107 0.837 rs3792108 chr2:234184952 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.69 0.38 1.3e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs6676180 0.514 rs868675 chr1:119773596 A/G cg05756136 chr1:119680316 WARS2 -0.41 -5.42 -0.32 1.32e-7 Monobrow; CESC cis rs4704187 0.687 rs1345705 chr5:74507007 C/A cg03227963 chr5:74354835 NA 0.28 5.19 0.3 4.21e-7 Response to amphetamines; CESC cis rs1018836 0.923 rs6986001 chr8:91650205 T/C cg16814680 chr8:91681699 NA -0.74 -11.4 -0.57 8.9e-25 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg26338869 chr17:61819248 STRADA 0.68 8.88 0.48 1.06e-16 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27452651 chr22:50312357 ALG12;CRELD2 -0.45 -6.18 -0.35 2.44e-9 Fibrinogen levels; CESC cis rs13108904 0.604 rs11946375 chr4:1313488 T/C cg00684032 chr4:1343700 KIAA1530 0.43 6.25 0.36 1.67e-9 Obesity-related traits; CESC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg25072359 chr17:41440525 NA 0.45 5.96 0.34 7.83e-9 Menopause (age at onset); CESC trans rs9467711 0.790 rs72843784 chr6:26498758 G/T cg01620082 chr3:125678407 NA -0.91 -6.59 -0.38 2.31e-10 Autism spectrum disorder or schizophrenia; CESC cis rs79387448 0.592 rs6728945 chr2:102986471 T/C cg09003973 chr2:102972529 NA 1.22 10.27 0.53 4.91e-21 Gut microbiota (bacterial taxa); CESC cis rs8058578 0.943 rs7197770 chr16:30715908 T/C cg00531865 chr16:30841666 NA -0.44 -5.77 -0.33 2.15e-8 Multiple myeloma; CESC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 6.94 0.39 2.94e-11 Bipolar disorder; CESC cis rs12155623 0.834 rs6472110 chr8:49784810 T/C cg22283653 chr8:49824208 NA -0.38 -5.37 -0.31 1.75e-7 Sudden cardiac arrest; CESC cis rs9488822 0.636 rs7745074 chr6:116347432 G/A cg26893134 chr6:116381904 FRK 0.25 6.14 0.35 3.03e-9 Cholesterol, total;LDL cholesterol; CESC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg26314531 chr2:26401878 FAM59B -0.82 -9.03 -0.48 3.69e-17 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03456755 chr17:75084957 SCARNA16;C17orf86 -0.42 -6.13 -0.35 3.11e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg24675658 chr1:53192096 ZYG11B -0.57 -7.0 -0.39 2.13e-11 Monocyte count; CESC cis rs72945132 0.882 rs72947078 chr11:70197542 G/T cg00319359 chr11:70116639 PPFIA1 0.81 7.2 0.4 6.16e-12 Coronary artery disease; CESC cis rs6688613 0.649 rs11584352 chr1:166850372 T/C ch.1.3259774R chr1:166827647 TADA1 0.55 5.32 0.31 2.23e-7 Refractive astigmatism; CESC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg07414643 chr4:187882934 NA -0.5 -7.03 -0.4 1.77e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg21782813 chr7:2030301 MAD1L1 0.42 5.83 0.34 1.59e-8 Schizophrenia; CESC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg24209194 chr3:40518798 ZNF619 0.5 6.28 0.36 1.42e-9 Renal cell carcinoma; CESC cis rs9362426 0.943 rs242291 chr6:88077083 A/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -5.7 -0.33 3.21e-8 Depressive episodes in bipolar disorder; CESC trans rs7246760 0.867 rs66943818 chr19:9746367 G/A cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg26314531 chr2:26401878 FAM59B 0.7 7.86 0.43 9.71e-14 Gut microbiome composition (summer); CESC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg22442454 chr1:209979470 IRF6 0.53 6.31 0.36 1.14e-9 Cleft lip with or without cleft palate; CESC trans rs6759922 1.000 rs4321395 chr2:22444221 G/A cg21162304 chr4:80247171 NAA11 0.38 6.24 0.36 1.72e-9 Subjective well-being (multi-trait analysis); CESC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg18225595 chr11:63971243 STIP1 0.52 5.13 0.3 5.56e-7 Mean platelet volume; CESC cis rs2735413 0.875 rs11649082 chr16:78082256 C/T cg04733911 chr16:78082701 NA -0.53 -8.93 -0.48 7.29e-17 Systolic blood pressure (alcohol consumption interaction); CESC trans rs11088226 1.000 rs11701627 chr21:33927794 T/A cg09050820 chr6:167586206 TCP10L2 0.6 6.09 0.35 3.97e-9 Gastritis; CESC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg19717773 chr7:2847554 GNA12 -0.57 -8.38 -0.46 3.07e-15 Height; CESC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.38 0.31 1.66e-7 Tonsillectomy; CESC trans rs4927850 1.000 rs4927850 chr3:195751630 C/T cg16724585 chr3:197361211 NA 0.54 7.02 0.4 1.89e-11 Pancreatic cancer; CESC cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.36 5.65 0.33 4.19e-8 Monocyte percentage of white cells; CESC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.73 -0.33 2.66e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg14558114 chr2:88469736 THNSL2 -0.49 -7.16 -0.4 8.01e-12 Response to metformin (IC50); CESC cis rs7219021 0.926 rs7209437 chr17:46855267 A/G cg16584676 chr17:46985605 UBE2Z -0.56 -6.32 -0.36 1.08e-9 Schizophrenia or bipolar disorder; CESC cis rs561341 1.000 rs555629 chr17:30294136 T/C cg00745463 chr17:30367425 LRRC37B -0.81 -7.35 -0.41 2.5e-12 Hip circumference adjusted for BMI; CESC cis rs10242455 0.702 rs3823813 chr7:99049389 G/A cg25640893 chr7:99214727 ZNF498 0.81 5.34 0.31 1.98e-7 Blood metabolite levels; CESC cis rs7845219 0.525 rs10956931 chr8:95930301 A/G cg09323728 chr8:95962352 TP53INP1 -0.29 -5.56 -0.32 6.67e-8 Type 2 diabetes; CESC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg04369109 chr6:150039330 LATS1 -0.38 -5.26 -0.31 3.04e-7 Lung cancer; CESC cis rs9303401 0.614 rs35245220 chr17:56510305 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.92 10.45 0.54 1.27e-21 Cognitive test performance; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg14159672 chr1:205819179 PM20D1 0.96 16.98 0.72 2.86e-44 Menarche (age at onset); CESC cis rs9359856 0.662 rs1179904 chr6:90322573 A/G cg13799429 chr6:90582589 CASP8AP2 0.54 6.09 0.35 3.98e-9 Bipolar disorder; CESC cis rs9308731 0.505 rs10169613 chr2:111934977 C/T cg04202892 chr2:111875749 ACOXL 0.43 5.84 0.34 1.52e-8 Chronic lymphocytic leukemia; CESC trans rs7666738 0.830 rs4292341 chr4:98959724 C/T cg11514184 chr1:161015941 USF1 0.43 6.13 0.35 3.25e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg12516959 chr21:47718080 NA -0.47 -6.45 -0.37 5.37e-10 Testicular germ cell tumor; CESC cis rs8070128 0.534 rs2955350 chr17:17953548 G/A cg09796270 chr17:17721594 SREBF1 -0.38 -5.07 -0.3 7.66e-7 Total body bone mineral density; CESC cis rs116095464 0.558 rs13356367 chr5:242395 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.63 -0.47 5.66e-16 Breast cancer; CESC cis rs67311347 0.544 rs12054197 chr3:40337562 C/T cg09455208 chr3:40491958 NA 0.36 6.35 0.36 9.37e-10 Renal cell carcinoma; CESC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg24642844 chr7:1081250 C7orf50 -0.71 -8.62 -0.47 6.13e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg08859206 chr1:53392774 SCP2 -0.58 -7.44 -0.42 1.45e-12 Monocyte count; CESC cis rs2839186 0.749 rs62226488 chr21:47710517 C/T cg10351095 chr21:47802916 PCNT -0.5 -6.75 -0.38 9.55e-11 Testicular germ cell tumor; CESC cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg06697600 chr4:7070879 GRPEL1 -0.47 -7.22 -0.41 5.6e-12 Monocyte percentage of white cells; CESC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg05347473 chr6:146136440 FBXO30 0.58 7.43 0.42 1.48e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs921968 0.643 rs492400 chr2:219349752 C/T cg02176678 chr2:219576539 TTLL4 0.4 7.13 0.4 9.47e-12 Mean corpuscular hemoglobin concentration; CESC cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7542091 0.704 rs2142907 chr1:210039505 T/C cg23283495 chr1:209979779 IRF6 0.33 5.23 0.31 3.38e-7 Monobrow; CESC cis rs10504073 0.626 rs9298106 chr8:50007508 T/G cg00325661 chr8:49890786 NA 0.51 7.78 0.43 1.65e-13 Blood metabolite ratios; CESC cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs11608355 0.545 rs12818120 chr12:109901916 C/T cg05360138 chr12:110035743 NA 0.84 9.16 0.49 1.46e-17 Neuroticism; CESC cis rs2115536 0.692 rs6495450 chr15:80162499 C/A cg11839771 chr15:80205821 ST20 -0.36 -5.29 -0.31 2.59e-7 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs116095464 0.558 rs6878061 chr5:223072 A/G cg22857025 chr5:266934 NA -1.27 -18.89 -0.76 5.51e-51 Breast cancer; CESC cis rs1691799 0.867 rs1168297 chr12:66735644 T/C cg16791601 chr12:66731901 HELB -0.75 -12.95 -0.62 4.83e-30 White blood cell count (basophil); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08132980 chr7:2632320 IQCE -0.57 -7.05 -0.4 1.51e-11 Gut microbiome composition (summer); CESC cis rs9611519 1.000 rs9611510 chr22:41569124 T/C cg03806693 chr22:41940476 POLR3H -0.57 -5.85 -0.34 1.42e-8 Neuroticism; CESC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg00475322 chr7:917719 C7orf20 0.46 5.1 0.3 6.53e-7 Cerebrospinal P-tau181p levels; CESC cis rs826838 0.967 rs826855 chr12:39114888 T/C cg26384229 chr12:38710491 ALG10B -0.67 -11.02 -0.56 1.72e-23 Heart rate; CESC cis rs7772486 0.686 rs1415744 chr6:146022531 C/T cg05347473 chr6:146136440 FBXO30 0.53 6.76 0.38 8.75e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1801251 0.727 rs283482 chr2:233646920 A/T cg08000102 chr2:233561755 GIGYF2 0.67 10.02 0.52 2.92e-20 Coronary artery disease; CESC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs11608355 0.557 rs759971 chr12:109826046 A/T cg19025524 chr12:109796872 NA -0.54 -7.73 -0.43 2.27e-13 Neuroticism; CESC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg17372223 chr3:52568218 NT5DC2 0.42 6.42 0.37 6.33e-10 Bipolar disorder; CESC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2011503 1.000 rs7252453 chr19:19654117 G/C cg20644253 chr19:19431407 KIAA0892;SF4 0.54 5.83 0.34 1.61e-8 Bipolar disorder; CESC cis rs959260 1.000 rs9902966 chr17:73362147 C/T cg20590849 chr17:73267439 MIF4GD -0.56 -6.44 -0.37 5.52e-10 Systemic lupus erythematosus; CESC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg00684032 chr4:1343700 KIAA1530 0.4 5.59 0.32 5.54e-8 Obesity-related traits; CESC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.18 0.3 4.42e-7 Bipolar disorder; CESC cis rs863345 0.604 rs11265021 chr1:158511810 A/T cg12129480 chr1:158549410 OR10X1 0.34 6.98 0.39 2.37e-11 Pneumococcal bacteremia; CESC cis rs6967414 0.579 rs6968879 chr7:6757886 T/G cg09896999 chr7:6746977 ZNF12 -0.52 -6.19 -0.36 2.31e-9 Hematocrit;Hemoglobin concentration; CESC cis rs11203032 0.831 rs7076185 chr10:90923524 G/A cg16672925 chr10:90967113 CH25H 0.7 6.65 0.38 1.62e-10 Heart failure; CESC cis rs2235544 0.565 rs650134 chr1:54467342 T/C cg25741118 chr1:54482237 LDLRAD1 0.24 5.77 0.33 2.2e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs1707322 0.821 rs11211182 chr1:46240170 G/A cg03146154 chr1:46216737 IPP 0.8 10.82 0.55 7.95e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4076764 1.000 rs6683181 chr1:163417077 C/T cg24596788 chr1:163392923 NA -0.49 -7.17 -0.4 7.57e-12 Motion sickness; CESC cis rs300703 0.542 rs300691 chr2:180171 C/A cg21211680 chr2:198530 NA -0.86 -9.51 -0.5 1.21e-18 Blood protein levels; CESC cis rs2228479 0.541 rs12918575 chr16:89811151 A/G cg04287289 chr16:89883240 FANCA 0.71 6.53 0.37 3.42e-10 Skin colour saturation; CESC cis rs1832871 0.672 rs11751553 chr6:158774750 C/T cg07165851 chr6:158734300 TULP4 -0.59 -6.12 -0.35 3.27e-9 Height; CESC cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.75 0.47 2.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10861342 0.892 rs7488014 chr12:105657527 C/T cg23923672 chr12:105501055 KIAA1033 0.68 5.88 0.34 1.25e-8 IgG glycosylation; CESC cis rs4423214 0.840 rs1792229 chr11:71179395 A/G cg05163923 chr11:71159392 DHCR7 -0.64 -7.61 -0.42 4.66e-13 Vitamin D levels; CESC trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg06636001 chr8:8085503 FLJ10661 0.49 6.27 0.36 1.46e-9 Retinal vascular caliber; CESC cis rs963731 0.649 rs1869513 chr2:39205315 A/G cg04010122 chr2:39346883 SOS1 -0.68 -5.09 -0.3 6.82e-7 Corticobasal degeneration; CESC cis rs1801251 0.964 rs10933411 chr2:233706847 A/G cg25237894 chr2:233734115 C2orf82 -0.46 -8.06 -0.44 2.65e-14 Coronary artery disease; CESC cis rs3740713 0.920 rs73438656 chr11:18455935 C/A cg23797887 chr11:18477753 LDHAL6A -0.53 -5.27 -0.31 2.89e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg19729930 chr2:74357872 NA 0.86 12.94 0.62 5.25e-30 Gestational age at birth (maternal effect); CESC trans rs62103177 0.810 rs62096746 chr18:77619556 T/A cg05926928 chr17:57297772 GDPD1 1.2 10.71 0.55 1.82e-22 Opioid sensitivity; CESC cis rs4594175 0.926 rs4901084 chr14:51634131 G/A cg23942311 chr14:51606299 NA 0.39 6.03 0.35 5.6e-9 Cancer; CESC cis rs4523957 0.552 rs923862 chr17:2031382 A/C cg16513277 chr17:2031491 SMG6 -0.79 -11.73 -0.58 6.95e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7829975 0.511 rs2976902 chr8:8341105 T/G cg06636001 chr8:8085503 FLJ10661 0.42 5.09 0.3 6.68e-7 Mood instability; CESC cis rs9486719 0.948 rs2499817 chr6:96878321 C/T cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs367943 0.712 rs26959 chr5:112736615 A/G cg12552261 chr5:112820674 MCC 0.4 5.32 0.31 2.21e-7 Type 2 diabetes; CESC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.98 0.34 7.35e-9 Tonsillectomy; CESC cis rs362272 0.524 rs2857982 chr4:3358665 G/A cg08886695 chr4:3369023 RGS12 -0.43 -5.95 -0.34 8.67e-9 Serum sulfate level; CESC cis rs7312774 0.748 rs1861746 chr12:107301518 G/A cg16260113 chr12:107380972 MTERFD3 0.65 6.12 0.35 3.43e-9 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10514235 chr4:15003844 NA 0.53 6.4 0.37 6.97e-10 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg24562669 chr7:97807699 LMTK2 0.48 7.0 0.4 2.09e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs11190604 1.000 rs2489050 chr10:102350898 T/A cg07080220 chr10:102295463 HIF1AN 0.6 5.3 0.31 2.43e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg16325326 chr1:53192061 ZYG11B -0.87 -14.76 -0.67 2.25e-36 Monocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19523618 chr12:125438446 DHX37 0.49 6.35 0.36 9.29e-10 Fibrinogen levels; CESC cis rs7618501 0.699 rs6446187 chr3:49907111 C/A cg24308560 chr3:49941425 MST1R -0.68 -10.12 -0.53 1.45e-20 Intelligence (multi-trait analysis); CESC cis rs11098499 0.820 rs28578366 chr4:120536905 A/G cg24375607 chr4:120327624 NA -0.46 -5.67 -0.33 3.82e-8 Corneal astigmatism; CESC trans rs2823962 0.759 rs8134854 chr21:18016042 C/T cg06419850 chr17:4688683 VMO1 -0.43 -6.1 -0.35 3.83e-9 Amyotrophic lateral sclerosis; CESC cis rs1707322 0.662 rs11211160 chr1:46146229 T/A cg06784218 chr1:46089804 CCDC17 0.4 7.04 0.4 1.63e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg17509989 chr5:176798049 RGS14 0.48 5.78 0.33 2.12e-8 Hemoglobin concentration;Hematocrit; CESC cis rs7592578 0.679 rs59929070 chr2:191327852 A/G cg27211696 chr2:191398769 TMEM194B -0.59 -5.88 -0.34 1.25e-8 Diastolic blood pressure; CESC cis rs2635047 0.519 rs2668771 chr18:44775897 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.35 0.31 1.88e-7 Educational attainment; CESC cis rs1712517 0.524 rs1712509 chr10:105013870 G/T cg04362960 chr10:104952993 NT5C2 -0.48 -5.71 -0.33 2.96e-8 Migraine; CESC cis rs4629710 0.545 rs2077490 chr6:131554184 C/T cg12606694 chr6:131520996 AKAP7 0.46 5.86 0.34 1.36e-8 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11891330 chr4:2010714 WHSC2 -0.58 -6.33 -0.36 1.02e-9 Gut microbiome composition (summer); CESC cis rs9788682 0.747 rs16969894 chr15:78776456 C/T cg24631222 chr15:78858424 CHRNA5 0.64 7.6 0.42 5.15e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00045532 chr12:38493714 NA -0.61 -7.63 -0.42 4.21e-13 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02931907 chr8:94753245 RBM12B 0.44 6.2 0.36 2.15e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg11317459 chr13:21872234 NA 1.18 15.36 0.69 1.57e-38 White matter hyperintensity burden; CESC cis rs7666738 0.830 rs880470 chr4:98922522 A/T cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17584085 chr17:46688329 HOXB7 -0.45 -6.24 -0.36 1.69e-9 Gut microbiota (bacterial taxa); CESC cis rs6580649 0.941 rs4760615 chr12:48428150 A/G cg05342945 chr12:48394962 COL2A1 -0.52 -6.06 -0.35 4.61e-9 Lung cancer; CESC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg18876405 chr7:65276391 NA 0.53 7.06 0.4 1.47e-11 Aortic root size; CESC cis rs9911578 0.900 rs717828 chr17:56535932 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.94 -0.39 2.97e-11 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15342139 chr6:170124938 PHF10 -0.46 -6.38 -0.36 7.85e-10 Fibrinogen levels; CESC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg14893161 chr1:205819251 PM20D1 0.86 14.4 0.66 4.17e-35 Menarche (age at onset); CESC cis rs7520050 0.966 rs785471 chr1:46518677 T/C cg24296786 chr1:45957014 TESK2 0.41 5.12 0.3 5.92e-7 Red blood cell count;Reticulocyte count; CESC trans rs208520 0.690 rs12213581 chr6:66735818 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.22 0.6 1.51e-27 Exhaled nitric oxide output; CESC cis rs910316 0.763 rs2080201 chr14:75629972 C/T cg16144293 chr14:75469539 EIF2B2 0.39 5.04 0.3 8.77e-7 Height; CESC cis rs6088580 0.634 rs6058051 chr20:33044862 G/A cg24642439 chr20:33292090 TP53INP2 0.52 6.9 0.39 3.77e-11 Glomerular filtration rate (creatinine); CESC cis rs853679 1.000 rs13200462 chr6:28218199 A/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.74 7.3 0.41 3.39e-12 Depression; CESC cis rs10751667 0.666 rs7395182 chr11:927553 A/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.26 -0.31 2.96e-7 Alzheimer's disease (late onset); CESC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg03060546 chr3:49711283 APEH 0.54 7.09 0.4 1.2e-11 Menarche (age at onset); CESC cis rs116095464 0.867 rs10074958 chr5:230828 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.23 0.31 3.47e-7 Breast cancer; CESC cis rs2243480 1.000 rs1618893 chr7:66096119 C/T cg12463550 chr7:65579703 CRCP 0.63 5.63 0.33 4.64e-8 Diabetic kidney disease; CESC cis rs9611565 0.649 rs202666 chr22:41814719 T/C cg06634786 chr22:41940651 POLR3H 0.72 7.58 0.42 5.66e-13 Vitiligo; CESC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg25405998 chr7:65216604 CCT6P1 -0.45 -5.06 -0.3 7.71e-7 Aortic root size; CESC cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.38 -6.63 -0.38 1.92e-10 Hemoglobin concentration; CESC cis rs660498 0.507 rs4018734 chr10:27741269 G/A cg25705717 chr10:27608719 NA 0.47 5.73 0.33 2.73e-8 Asthma (childhood onset); CESC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg07677032 chr17:61819896 STRADA 0.45 5.9 0.34 1.12e-8 Prudent dietary pattern; CESC cis rs11203032 0.831 rs2902445 chr10:90934154 A/G cg16672925 chr10:90967113 CH25H 0.69 6.54 0.37 3.17e-10 Heart failure; CESC cis rs9486719 0.843 rs2472875 chr6:96844691 G/A cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC trans rs17685 0.725 rs7807647 chr7:75628669 G/A cg19862616 chr7:65841803 NCRNA00174 -0.81 -11.87 -0.59 2.41e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.1 0.4 1.11e-11 Height; CESC cis rs4805272 0.512 rs4805278 chr19:29336664 C/T cg12756686 chr19:29218302 NA 0.4 5.2 0.3 3.94e-7 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs11997175 0.574 rs4538830 chr8:33653741 C/G ch.8.33884649F chr8:33765107 NA 0.66 8.38 0.46 3.14e-15 Body mass index; CESC cis rs9834373 0.853 rs6797869 chr3:78495322 C/T cg06138941 chr3:78371609 NA -0.42 -5.18 -0.3 4.45e-7 Protein quantitative trait loci; CESC cis rs2180341 0.618 rs11154398 chr6:127654281 C/A cg27446573 chr6:127587934 RNF146 0.63 8.54 0.46 1.09e-15 Breast cancer; CESC cis rs7927771 0.524 rs7939420 chr11:47723938 A/G cg18512352 chr11:47633146 NA -0.35 -5.46 -0.32 1.1e-7 Subjective well-being; CESC cis rs4664308 0.875 rs60908067 chr2:161004983 T/G cg03641300 chr2:160917029 PLA2R1 -0.65 -9.48 -0.5 1.49e-18 Idiopathic membranous nephropathy; CESC cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg05535760 chr7:792225 HEATR2 0.85 10.38 0.54 2.06e-21 Cerebrospinal P-tau181p levels; CESC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.18 0.3 4.4e-7 Colonoscopy-negative controls vs population controls; CESC cis rs5757673 1 rs5757673 chr22:39837920 T/C cg11247378 chr22:39784982 NA -0.66 -8.9 -0.48 9.27e-17 Post bronchodilator FEV1; CESC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg18404041 chr3:52824283 ITIH1 -0.41 -6.82 -0.39 5.97e-11 Bipolar disorder; CESC cis rs4969178 0.930 rs7208596 chr17:76396528 C/G cg05887092 chr17:76393375 PGS1 0.58 9.22 0.49 9.9e-18 HDL cholesterol levels; CESC cis rs4969178 0.930 rs12452576 chr17:76386037 A/C cg20026190 chr17:76395443 PGS1 0.42 6.55 0.37 2.98e-10 HDL cholesterol levels; CESC cis rs1046896 0.731 rs9906115 chr17:80791469 G/A cg02711726 chr17:80685570 FN3KRP -0.4 -5.24 -0.31 3.29e-7 Glycated hemoglobin levels; CESC cis rs7772486 0.846 rs7755440 chr6:146375906 T/C cg23711669 chr6:146136114 FBXO30 0.89 13.12 0.63 1.2e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg02935154 chr7:12443704 VWDE -0.59 -6.9 -0.39 3.79e-11 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09555217 chr11:16759900 C11orf58 -0.7 -8.48 -0.46 1.58e-15 Gut microbiome composition (summer); CESC cis rs3741151 0.773 rs73544716 chr11:73170061 C/T cg17517138 chr11:73019481 ARHGEF17 1.0 7.41 0.41 1.74e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg27170947 chr2:26402098 FAM59B -0.84 -9.95 -0.52 4.91e-20 Gut microbiome composition (summer); CESC cis rs7520050 0.966 rs11211230 chr1:46406767 G/T cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.66e-9 Red blood cell count;Reticulocyte count; CESC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg10691866 chr7:65817282 TPST1 -0.32 -5.09 -0.3 6.81e-7 Aortic root size; CESC cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg05347473 chr6:146136440 FBXO30 0.59 7.59 0.42 5.36e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs858239 0.600 rs10256361 chr7:23123885 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.63 0.42 4.21e-13 Cerebrospinal fluid biomarker levels; CESC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.93 0.59 1.49e-26 Alzheimer's disease; CESC cis rs4132509 0.649 rs12140040 chr1:243871922 G/A cg21452805 chr1:244014465 NA 0.63 6.85 0.39 5.02e-11 RR interval (heart rate); CESC cis rs4481887 1.000 rs4244174 chr1:248467956 A/G cg00666640 chr1:248458726 OR2T12 0.39 6.36 0.36 8.71e-10 Common traits (Other); CESC cis rs9300255 0.544 rs2049114 chr12:123657338 T/C cg05973401 chr12:123451056 ABCB9 0.49 5.45 0.32 1.18e-7 Neutrophil percentage of white cells; CESC cis rs7084402 0.967 rs1658436 chr10:60326910 G/A cg07615347 chr10:60278583 BICC1 0.58 8.91 0.48 8.41e-17 Refractive error; CESC trans rs11098499 0.955 rs7684942 chr4:120162201 C/T cg25214090 chr10:38739885 LOC399744 0.64 8.53 0.46 1.16e-15 Corneal astigmatism; CESC cis rs208520 0.690 rs12209753 chr6:66703951 A/G cg07460842 chr6:66804631 NA 0.97 13.24 0.63 4.76e-31 Exhaled nitric oxide output; CESC cis rs2797160 1.000 rs2747717 chr6:126008435 A/G cg05901451 chr6:126070800 HEY2 0.45 6.51 0.37 3.77e-10 Endometrial cancer; CESC cis rs870825 0.616 rs6833858 chr4:185639961 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.15 0.4 8.53e-12 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01182386 chr15:75182373 MPI 0.65 7.87 0.44 8.87e-14 Gut microbiome composition (summer); CESC cis rs11098499 0.954 rs28429722 chr4:120300093 G/A cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs763014 0.865 rs8909 chr16:633851 T/C cg00802000 chr16:706648 WDR90 -0.39 -5.81 -0.34 1.81e-8 Height; CESC cis rs2932538 0.922 rs12048528 chr1:113210534 A/C cg22162597 chr1:113214053 CAPZA1 -0.56 -7.11 -0.4 1.1e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs561341 0.783 rs512698 chr17:30292507 G/T cg12193833 chr17:30244370 NA -0.71 -6.56 -0.37 2.86e-10 Hip circumference adjusted for BMI; CESC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg07090678 chr1:91966139 CDC7 0.4 5.54 0.32 7.19e-8 Breast cancer; CESC trans rs12479064 0.724 rs6748200 chr2:100080895 G/A cg20598333 chr11:3663511 ART5 0.52 6.18 0.35 2.41e-9 Chronic sinus infection; CESC cis rs3820928 0.845 rs13384342 chr2:227805010 G/A cg05526886 chr2:227700861 RHBDD1 -0.44 -5.68 -0.33 3.52e-8 Pulmonary function; CESC cis rs10911251 0.546 rs2274984 chr1:183107446 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.82 -12.53 -0.61 1.38e-28 Colorectal cancer; CESC trans rs6600671 0.902 rs2222371 chr1:121289118 T/C cg17023122 chr1:144479586 NA -0.5 -6.57 -0.37 2.67e-10 Hip geometry; CESC cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs66573146 0.572 rs67922134 chr4:6955772 G/A cg00086871 chr4:6988644 TBC1D14 1.05 6.88 0.39 4.25e-11 Granulocyte percentage of myeloid white cells; CESC cis rs7772486 0.875 rs864390 chr6:146315035 G/T cg05347473 chr6:146136440 FBXO30 0.52 6.98 0.39 2.32e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7481584 0.624 rs1077335 chr11:3030524 A/G cg25174290 chr11:3078921 CARS -0.48 -6.51 -0.37 3.85e-10 Calcium levels; CESC cis rs2425143 1.000 rs13038622 chr20:34319343 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.31 0.31 2.37e-7 Blood protein levels; CESC cis rs9596863 0.950 rs9568935 chr13:54397928 C/T ch.13.53330881F chr13:54432880 NA 0.66 5.36 0.31 1.84e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg12193833 chr17:30244370 NA -0.7 -6.49 -0.37 4.19e-10 Hip circumference adjusted for BMI; CESC cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg05234568 chr11:5960015 NA -0.62 -7.41 -0.41 1.74e-12 DNA methylation (variation); CESC cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.66 8.67 0.47 4.33e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs8070740 0.898 rs4790770 chr17:5324893 A/C cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.35 0.36 9.3e-10 Menopause (age at onset); CESC cis rs79839061 0.518 rs3755960 chr4:895060 G/T cg07828340 chr4:882639 GAK 1.07 8.27 0.45 6.45e-15 Intelligence (multi-trait analysis); CESC cis rs1355223 0.583 rs2956074 chr11:34864880 T/C cg11058730 chr11:34937778 PDHX;APIP 0.83 12.66 0.61 4.91e-29 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg04025307 chr7:1156635 C7orf50 0.45 7.06 0.4 1.44e-11 Longevity;Endometriosis; CESC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg06505273 chr16:24850292 NA 0.49 5.46 0.32 1.07e-7 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg23758822 chr17:41437982 NA 1.01 15.21 0.68 5.44e-38 Menopause (age at onset); CESC cis rs2243480 1.000 rs35283677 chr7:65359233 C/T cg25894440 chr7:65020034 NA -0.63 -5.42 -0.32 1.33e-7 Diabetic kidney disease; CESC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg14829155 chr15:31115871 NA -0.72 -9.72 -0.51 2.73e-19 Huntington's disease progression; CESC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg16325326 chr1:53192061 ZYG11B -0.88 -15.06 -0.68 1.8e-37 Monocyte count; CESC cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs17362650 0.921 rs35848871 chr2:9657827 A/G cg12832956 chr2:9616023 IAH1 -0.52 -5.09 -0.3 6.69e-7 Alcohol dependence (age at onset); CESC trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.58 8.4 0.46 2.71e-15 Intelligence (multi-trait analysis); CESC trans rs17789174 0.700 rs3794679 chr16:85104588 A/C cg23141902 chr22:39712694 RPL3;SNORD83A -0.42 -6.36 -0.36 8.61e-10 Dysphagia; CESC cis rs2985684 0.779 rs12160 chr14:50091932 T/A cg02151108 chr14:50098012 C14orf104 -0.45 -5.85 -0.34 1.43e-8 Carotid intima media thickness; CESC cis rs501120 0.810 rs474281 chr10:44749120 T/C cg09554077 chr10:44749378 NA 0.54 6.97 0.39 2.44e-11 Coronary artery disease;Coronary heart disease; CESC cis rs9911578 1.000 rs302848 chr17:56686454 C/T cg12560992 chr17:57184187 TRIM37 0.93 15.59 0.69 2.48e-39 Intelligence (multi-trait analysis); CESC cis rs748404 0.578 rs507178 chr15:43610135 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.6 8.0 0.44 3.9e-14 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13820145 chr20:26062310 FAM182A 0.39 6.36 0.36 8.89e-10 Fibrinogen levels; CESC cis rs8013055 0.846 rs8003942 chr14:105971670 A/G cg23356831 chr14:105996513 TMEM121 0.37 5.14 0.3 5.23e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC cis rs34734847 0.898 rs696339 chr12:121169436 A/T cg26008908 chr12:120799332 MSI1 0.34 5.23 0.31 3.53e-7 Mean corpuscular volume; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg15441325 chr3:106959341 LOC344595;LOC100302640 -0.4 -6.24 -0.36 1.74e-9 Vertical cup-disc ratio; CESC cis rs6598955 0.670 rs12733645 chr1:26540356 G/T cg04990556 chr1:26633338 UBXN11 -0.75 -10.6 -0.55 4.14e-22 Obesity-related traits; CESC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg03354898 chr7:1950403 MAD1L1 -0.31 -5.15 -0.3 5.11e-7 Bipolar disorder and schizophrenia; CESC cis rs9911578 1.000 rs2531732 chr17:56548420 T/A cg05425664 chr17:57184151 TRIM37 0.5 6.94 0.39 2.97e-11 Intelligence (multi-trait analysis); CESC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg17376030 chr22:41985996 PMM1 0.68 7.35 0.41 2.5e-12 Vitiligo; CESC cis rs1788820 0.843 rs1788821 chr18:21120869 A/G cg14672496 chr18:21087552 C18orf8 0.49 6.75 0.38 9.35e-11 Body mass index; CESC cis rs9303280 0.806 rs11078927 chr17:38064405 C/T cg20243544 chr17:37824526 PNMT 0.54 6.91 0.39 3.53e-11 Self-reported allergy; CESC cis rs4595586 0.525 rs35046524 chr12:39414535 A/G cg26384229 chr12:38710491 ALG10B 0.61 8.37 0.46 3.29e-15 Morning vs. evening chronotype; CESC cis rs9291683 0.530 rs998675 chr4:9948829 A/G cg00071950 chr4:10020882 SLC2A9 0.76 14.09 0.65 4.8e-34 Bone mineral density; CESC cis rs7662987 0.517 rs1133485 chr4:100023811 T/A cg12011299 chr4:100065546 ADH4 0.6 6.6 0.38 2.23e-10 Smoking initiation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08837462 chr7:90893760 FZD1 0.56 6.46 0.37 4.9e-10 Gut microbiome composition (summer); CESC trans rs5417 0.662 rs8067500 chr17:7172631 A/G cg15655154 chr3:113604241 GRAMD1C 0.69 8.69 0.47 3.7e-16 Diastolic blood pressure; CESC cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.18 0.3 4.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11264213 0.686 rs72661655 chr1:36475401 G/T cg27506609 chr1:36549197 TEKT2 0.69 5.65 0.33 4.09e-8 Schizophrenia; CESC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg02071572 chr4:1403502 NA -0.36 -5.46 -0.32 1.1e-7 Longevity; CESC cis rs6570726 0.935 rs454614 chr6:145832633 C/T cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg17650747 chr5:1873721 NA 0.45 6.24 0.36 1.74e-9 Cardiovascular disease risk factors; CESC cis rs113835537 0.529 rs11821155 chr11:66246337 C/T cg24851651 chr11:66362959 CCS -0.44 -5.58 -0.32 5.98e-8 Airway imaging phenotypes; CESC cis rs8180040 1.000 rs807810 chr3:47403892 G/A cg27129171 chr3:47204927 SETD2 -0.66 -10.01 -0.52 3.3e-20 Colorectal cancer; CESC cis rs13191362 0.507 rs2849525 chr6:163126652 A/C cg06582575 chr6:163149167 PACRG;PARK2 -0.51 -5.97 -0.34 7.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11098499 0.863 rs7664986 chr4:120429952 A/C cg09307838 chr4:120376055 NA 0.93 12.74 0.62 2.6e-29 Corneal astigmatism; CESC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg04944784 chr2:26401820 FAM59B -0.93 -10.75 -0.55 1.28e-22 Gut microbiome composition (summer); CESC cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg18357645 chr12:58087776 OS9 -0.43 -5.98 -0.34 7.09e-9 Multiple sclerosis; CESC cis rs7818688 1.000 rs10111300 chr8:96025631 C/G cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.55 -7.35 -0.41 2.44e-12 Menarche (age at onset); CESC cis rs7605827 0.930 rs12692265 chr2:15544998 T/C cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.72e-10 Educational attainment (years of education); CESC cis rs1008375 0.966 rs3733581 chr4:17695206 C/G cg02297831 chr4:17616191 MED28 -0.53 -6.34 -0.36 9.65e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1707322 1.000 rs4524994 chr1:46370263 A/G cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6088580 0.524 rs7269596 chr20:33229063 T/C cg24642439 chr20:33292090 TP53INP2 -0.45 -5.24 -0.31 3.3e-7 Glomerular filtration rate (creatinine); CESC cis rs4132509 0.793 rs9428579 chr1:243690034 C/T cg21452805 chr1:244014465 NA 0.45 5.08 0.3 7.23e-7 RR interval (heart rate); CESC cis rs9467773 0.620 rs2504567 chr6:26662920 C/G cg26531700 chr6:26746687 NA -0.39 -5.97 -0.34 7.57e-9 Intelligence (multi-trait analysis); CESC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg08888203 chr3:10149979 C3orf24 0.51 6.88 0.39 4.33e-11 Alzheimer's disease; CESC cis rs4835473 0.897 rs55635947 chr4:144657371 G/A cg25736465 chr4:144833511 NA -0.32 -5.07 -0.3 7.49e-7 Immature fraction of reticulocytes; CESC cis rs11098499 0.866 rs9995136 chr4:120286845 A/G cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC trans rs7922314 0.571 rs61865722 chr10:64755548 G/A cg06935979 chr1:232941706 KIAA1383 -0.64 -6.12 -0.35 3.3e-9 Cutaneous psoriasis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03484267 chr2:207988651 KLF7 0.46 6.23 0.36 1.82e-9 Fibrinogen levels; CESC cis rs62064224 0.614 rs4794923 chr17:30763009 G/A cg18200150 chr17:30822561 MYO1D 0.42 5.45 0.32 1.15e-7 Schizophrenia; CESC cis rs6547741 0.967 rs4665995 chr2:27813827 T/G cg21248554 chr2:27665150 KRTCAP3 0.25 5.08 0.3 7.23e-7 Oral cavity cancer; CESC cis rs4588572 0.643 rs10068686 chr5:77795220 C/T cg11547950 chr5:77652471 NA -0.44 -5.66 -0.33 3.96e-8 Triglycerides; CESC cis rs6500395 1.000 rs1362636 chr16:48712779 T/C cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9300255 0.544 rs1716175 chr12:123658388 A/T cg00376283 chr12:123451042 ABCB9 0.7 8.46 0.46 1.87e-15 Neutrophil percentage of white cells; CESC cis rs8180040 0.966 rs12632132 chr3:47477019 C/T cg27129171 chr3:47204927 SETD2 0.62 9.25 0.49 7.87e-18 Colorectal cancer; CESC cis rs9611519 0.732 rs1883826 chr22:41703428 G/A cg06634786 chr22:41940651 POLR3H -0.5 -5.35 -0.31 1.91e-7 Neuroticism; CESC cis rs709400 0.663 rs7152202 chr14:103886757 A/G cg12935359 chr14:103987150 CKB -0.5 -7.45 -0.42 1.28e-12 Body mass index; CESC cis rs12048904 0.595 rs2295280 chr1:101342497 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.69 9.96 0.52 4.76e-20 Multiple sclerosis; CESC cis rs4835473 0.831 rs4125544 chr4:144883695 G/T cg25736465 chr4:144833511 NA 0.38 5.57 0.32 6.4e-8 Immature fraction of reticulocytes; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg07751222 chr4:102268245 PPP3CA -0.61 -8.12 -0.45 1.77e-14 Thyroid stimulating hormone; CESC cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg04267008 chr7:1944627 MAD1L1 -0.5 -5.86 -0.34 1.34e-8 Bipolar disorder and schizophrenia; CESC cis rs9399137 0.507 rs11753673 chr6:135316476 T/C cg22676075 chr6:135203613 NA 0.53 7.09 0.4 1.22e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs12579753 0.917 rs7132465 chr12:82205840 C/T cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg02807482 chr3:125708958 NA -0.38 -5.34 -0.31 1.98e-7 Blood pressure (smoking interaction); CESC cis rs6964587 0.869 rs10276682 chr7:91486070 G/A cg17063962 chr7:91808500 NA -0.53 -7.23 -0.41 5.28e-12 Breast cancer; CESC cis rs9522267 0.535 rs9522286 chr13:112230909 A/G cg10483660 chr13:112241077 NA -0.33 -5.83 -0.34 1.65e-8 Hepatitis; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18485729 chr3:113774958 QTRTD1;KIAA1407 -0.45 -6.2 -0.36 2.18e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7098414 0.511 rs10887828 chr10:82151470 T/C cg00277334 chr10:82204260 NA -0.5 -7.37 -0.41 2.23e-12 Post bronchodilator FEV1; CESC cis rs12142240 0.628 rs56126529 chr1:46808860 C/T cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs5167 0.504 rs7248162 chr19:45454686 T/C cg09555818 chr19:45449301 APOC2 0.41 6.54 0.37 3.08e-10 Blood protein levels; CESC cis rs3771570 0.901 rs56129392 chr2:242242439 C/T cg21155796 chr2:242212141 HDLBP 0.61 5.16 0.3 4.88e-7 Prostate cancer; CESC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg02187348 chr16:89574699 SPG7 0.64 8.83 0.48 1.42e-16 Multiple myeloma (IgH translocation); CESC cis rs7635838 0.819 rs4684072 chr3:11514860 A/G cg00170343 chr3:11313890 ATG7 0.43 5.8 0.34 1.93e-8 HDL cholesterol; CESC cis rs6690583 0.623 rs1371143 chr1:85455532 C/T cg22153463 chr1:85462885 MCOLN2 0.72 7.37 0.41 2.15e-12 Serum sulfate level; CESC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg02353165 chr6:42928485 GNMT 0.94 17.36 0.73 1.35e-45 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg25427524 chr10:38739819 LOC399744 -0.7 -10.24 -0.53 6.01e-21 Extrinsic epigenetic age acceleration; CESC cis rs9815354 0.638 rs56008529 chr3:42026755 A/T cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs9875589 0.509 rs2731332 chr3:14110083 G/C cg19554555 chr3:13937349 NA -0.45 -5.84 -0.34 1.54e-8 Ovarian reserve; CESC cis rs7000551 0.505 rs4872499 chr8:22293306 A/G cg12081754 chr8:22256438 SLC39A14 -0.81 -9.79 -0.52 1.61e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg06221963 chr1:154839813 KCNN3 -0.73 -12.88 -0.62 8.02e-30 Prostate cancer; CESC cis rs1348850 0.526 rs4243389 chr2:178379783 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.68 6.17 0.35 2.52e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3780486 0.505 rs1411609 chr9:33137303 C/T cg13443165 chr9:33130375 B4GALT1 0.47 7.15 0.4 8.29e-12 IgG glycosylation; CESC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg11764359 chr7:65958608 NA 0.79 9.51 0.5 1.18e-18 Aortic root size; CESC cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -8.42 -0.46 2.39e-15 Hemoglobin concentration; CESC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg23758822 chr17:41437982 NA 0.96 16.32 0.71 6.62e-42 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02951695 chr10:134400351 INPP5A -0.58 -6.08 -0.35 4.14e-9 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25844211 chr1:229761456 URB2;TAF5L -0.51 -6.17 -0.35 2.56e-9 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18539546 chr1:174992693 MRPS14 -0.49 -6.45 -0.37 5.33e-10 Fibrinogen levels; CESC cis rs7756236 0.521 rs9394368 chr6:36630525 C/G cg08179530 chr6:36648295 CDKN1A -0.63 -9.27 -0.49 6.86e-18 QRS duration; CESC trans rs9325144 0.671 rs7485963 chr12:38768254 C/G cg23762105 chr12:34175262 ALG10 0.48 6.27 0.36 1.49e-9 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15674175 chr20:278095 ZCCHC3 0.55 6.21 0.36 2.08e-9 Gut microbiome composition (summer); CESC cis rs711245 0.572 rs3821150 chr2:36795233 G/A cg09467607 chr2:36825704 FEZ2 0.56 9.1 0.49 2.3e-17 Height; CESC cis rs9291683 0.609 rs13141233 chr4:10028729 T/C cg11266682 chr4:10021025 SLC2A9 0.7 14.15 0.66 2.99e-34 Bone mineral density; CESC cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg10523679 chr1:76189770 ACADM 0.76 10.18 0.53 9.1e-21 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7666738 0.830 rs35560671 chr4:99069095 G/A cg05340658 chr4:99064831 C4orf37 0.83 12.82 0.62 1.36e-29 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg06074448 chr4:187884817 NA -0.38 -5.49 -0.32 9.35e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg08888203 chr3:10149979 C3orf24 0.46 6.01 0.35 6.24e-9 Alzheimer's disease; CESC cis rs9611519 0.780 rs9611546 chr22:41698542 C/G cg06481639 chr22:41940642 POLR3H -0.53 -5.85 -0.34 1.41e-8 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00120998 chr16:67881473 CENPT;NUTF2 0.72 8.63 0.47 5.88e-16 Gut microbiome composition (summer); CESC cis rs7940866 0.903 rs7942900 chr11:130839244 G/A cg12179176 chr11:130786555 SNX19 0.62 8.78 0.47 2.05e-16 Schizophrenia; CESC cis rs11077998 0.901 rs4789798 chr17:80531643 C/G cg10255544 chr17:80519551 FOXK2 0.55 8.71 0.47 3.34e-16 Reticulocyte fraction of red cells; CESC cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.42 -6.95 -0.39 2.78e-11 Personality dimensions; CESC cis rs8077577 0.747 rs57697650 chr17:18224695 G/A cg16794390 chr17:18148240 FLII 0.4 6.34 0.36 9.98e-10 Obesity-related traits; CESC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg06456125 chr7:65229604 NA 0.39 5.37 0.31 1.75e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02607779 chr2:208030673 KLF7 -0.48 -6.99 -0.39 2.26e-11 Fibrinogen levels; CESC cis rs116988415 0.584 rs78748209 chr14:65255676 C/T cg25083366 chr14:65239357 SPTB 0.71 5.36 0.31 1.8e-7 Daytime sleep phenotypes; CESC cis rs4713675 0.584 rs3227 chr6:33662295 G/C cg15676125 chr6:33679581 C6orf125 0.34 5.2 0.3 3.95e-7 Plateletcrit; CESC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg24829409 chr8:58192753 C8orf71 -0.49 -5.99 -0.35 6.9e-9 Developmental language disorder (linguistic errors); CESC cis rs11971779 0.941 rs4732368 chr7:139034207 A/C cg07862535 chr7:139043722 LUC7L2 0.54 5.56 0.32 6.42e-8 Diisocyanate-induced asthma; CESC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg05457628 chr5:178986728 RUFY1 -0.53 -8.08 -0.44 2.23e-14 Lung cancer; CESC cis rs11650494 0.710 rs77653195 chr17:47468868 A/T cg08112188 chr17:47440006 ZNF652 1.19 8.04 0.44 3.04e-14 Prostate cancer; CESC cis rs1499614 1.000 rs1638731 chr7:66144679 C/T cg13147721 chr7:65941812 NA -0.96 -9.03 -0.49 3.58e-17 Gout; CESC cis rs4268898 0.662 rs17789375 chr2:24502554 G/T cg20701182 chr2:24300061 SF3B14 0.6 6.75 0.38 9.29e-11 Asthma; CESC cis rs11155671 0.530 rs2342770 chr6:150216685 C/T cg09699651 chr6:150184138 LRP11 0.54 7.43 0.42 1.48e-12 Testicular germ cell tumor; CESC cis rs7605378 0.567 rs717915 chr2:200714766 C/T cg23649088 chr2:200775458 C2orf69 0.71 8.87 0.48 1.1e-16 Osteoporosis; CESC cis rs9905704 0.647 rs11650809 chr17:56972741 A/G cg12560992 chr17:57184187 TRIM37 0.62 7.63 0.42 4.12e-13 Testicular germ cell tumor; CESC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg02524346 chr8:600233 NA 0.85 6.05 0.35 4.93e-9 IgG glycosylation; CESC cis rs4689388 0.610 rs4328980 chr4:6281756 A/G cg25554036 chr4:6271136 WFS1 0.5 6.95 0.39 2.88e-11 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg07395648 chr5:131743802 NA 0.41 5.35 0.31 1.86e-7 Breast cancer; CESC cis rs8014204 0.570 rs7147721 chr14:75186010 A/G cg08847533 chr14:75593920 NEK9 0.49 6.18 0.36 2.38e-9 Caffeine consumption; CESC cis rs9790314 0.905 rs1154701 chr3:161008025 T/A cg04691961 chr3:161091175 C3orf57 -0.41 -5.37 -0.31 1.7e-7 Morning vs. evening chronotype; CESC cis rs12618769 0.520 rs4851135 chr2:99050705 T/A cg10123293 chr2:99228465 UNC50 0.41 5.51 0.32 8.4e-8 Bipolar disorder; CESC cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 7.45 0.42 1.29e-12 Personality dimensions; CESC cis rs4253772 0.592 rs1807600 chr22:46644640 A/G cg09491104 chr22:46646882 C22orf40 -0.56 -8.7 -0.47 3.55e-16 LDL cholesterol;Cholesterol, total; CESC cis rs2050392 0.792 rs9338188 chr10:30721963 G/C cg25182066 chr10:30743637 MAP3K8 -0.44 -5.96 -0.34 7.81e-9 Inflammatory bowel disease; CESC cis rs372883 0.648 rs15092 chr21:30718201 G/A cg24692254 chr21:30365293 RNF160 -0.54 -6.71 -0.38 1.2e-10 Pancreatic cancer; CESC cis rs4789693 0.938 rs8078595 chr17:80426988 G/T cg04308225 chr17:80449738 NA 0.45 5.26 0.31 3.02e-7 Glucocorticoid-induced osteonecrosis; CESC cis rs6831352 0.918 rs28987097 chr4:100049579 C/T cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs11098499 0.863 rs11947234 chr4:120474859 A/G cg24375607 chr4:120327624 NA 0.45 5.54 0.32 7.33e-8 Corneal astigmatism; CESC cis rs17641971 0.619 rs6983929 chr8:49984896 T/C cg00325661 chr8:49890786 NA 0.36 5.13 0.3 5.72e-7 Blood metabolite levels; CESC cis rs1348850 0.567 rs3821006 chr2:178537694 G/A cg22681709 chr2:178499509 PDE11A -0.48 -7.68 -0.43 3e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6741892 0.536 rs7590835 chr2:38893950 A/G cg05275752 chr2:38892887 GALM 0.47 6.67 0.38 1.5e-10 5-HTT brain serotonin transporter levels; CESC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg11644478 chr21:40555479 PSMG1 -0.84 -12.62 -0.61 6.4e-29 Cognitive function; CESC cis rs35110281 0.600 rs914198 chr21:45117456 A/C cg01579765 chr21:45077557 HSF2BP -0.51 -8.35 -0.46 3.74e-15 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13099829 chr1:2237991 SKI -0.57 -6.49 -0.37 4.12e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09985698 chr21:45759020 C21orf2 0.61 6.76 0.38 9.01e-11 Gut microbiome composition (summer); CESC cis rs2637266 0.807 rs2256413 chr10:78315334 C/T cg18941641 chr10:78392320 NA -0.31 -5.2 -0.3 3.93e-7 Pulmonary function; CESC cis rs807669 0.835 rs698423 chr22:19197896 T/C cg02655711 chr22:19163373 SLC25A1 0.96 14.09 0.65 5.02e-34 Metabolite levels; CESC cis rs3857536 0.813 rs2040591 chr6:66945915 A/G cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg08470875 chr2:26401718 FAM59B -0.46 -5.05 -0.3 8.16e-7 Gut microbiome composition (summer); CESC cis rs7618501 1.000 rs6785549 chr3:49736565 G/A cg24308560 chr3:49941425 MST1R 0.5 6.86 0.39 4.8e-11 Intelligence (multi-trait analysis); CESC cis rs6800768 0.633 rs59715267 chr3:24100414 C/A cg10674438 chr3:24145617 LOC152024 -0.4 -5.32 -0.31 2.23e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg21970626 chr13:21893289 NA -0.42 -6.09 -0.35 3.85e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg07157506 chr18:12883603 PTPN2 -0.49 -7.45 -0.42 1.32e-12 Vertical cup-disc ratio; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg21755440 chr3:20227801 SGOL1 -0.48 -6.41 -0.37 6.47e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs35123781 0.696 rs904612 chr5:139070952 G/A cg10513866 chr5:139070639 NA 0.43 6.12 0.35 3.33e-9 Schizophrenia; CESC cis rs561341 0.882 rs28649357 chr17:30367190 A/G cg00745463 chr17:30367425 LRRC37B -0.59 -5.96 -0.34 7.98e-9 Hip circumference adjusted for BMI; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg04590956 chr2:70057467 GMCL1 0.55 7.02 0.4 1.84e-11 Tetralogy of Fallot; CESC cis rs9457247 1.000 rs408918 chr6:167399282 G/T cg23791538 chr6:167370224 RNASET2 -0.57 -7.91 -0.44 7.09e-14 Crohn's disease; CESC cis rs2380220 0.872 rs4546494 chr6:95990626 A/C cg04719120 chr6:96025338 MANEA 0.55 5.52 0.32 7.89e-8 Behavioural disinhibition (generation interaction); CESC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg07936489 chr17:37558343 FBXL20 0.77 10.56 0.54 5.54e-22 Glomerular filtration rate (creatinine); CESC cis rs116095464 0.558 rs10462754 chr5:246669 T/C cg22496380 chr5:211416 CCDC127 -0.75 -8.7 -0.47 3.49e-16 Breast cancer; CESC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.41 5.82 0.34 1.69e-8 Schizophrenia; CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg18110333 chr6:292329 DUSP22 -0.74 -9.66 -0.51 4.11e-19 Menopause (age at onset); CESC cis rs10911232 0.507 rs4652766 chr1:182994336 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs9902453 0.817 rs1038089 chr17:28178724 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.3 0.45 5.54e-15 Coffee consumption (cups per day); CESC cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg01579765 chr21:45077557 HSF2BP -0.54 -9.0 -0.48 4.6e-17 Mean corpuscular volume; CESC cis rs684232 0.543 rs4968095 chr17:507539 A/G cg15660573 chr17:549704 VPS53 -0.78 -11.44 -0.58 6.66e-25 Prostate cancer; CESC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg13126279 chr21:47581558 C21orf56 -0.47 -6.46 -0.37 4.99e-10 Testicular germ cell tumor; CESC cis rs7851660 0.839 rs2417575 chr9:100628642 G/A cg13688889 chr9:100608707 NA -0.63 -8.87 -0.48 1.09e-16 Strep throat; CESC cis rs11785400 1.000 rs3802232 chr8:143746701 A/G cg24634471 chr8:143751801 JRK 0.47 6.21 0.36 2e-9 Schizophrenia; CESC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg11890956 chr21:40555474 PSMG1 -0.64 -8.71 -0.47 3.25e-16 Menarche (age at onset); CESC cis rs7845219 0.539 rs13271644 chr8:95853948 A/G cg16049864 chr8:95962084 TP53INP1 -0.49 -7.56 -0.42 6.76e-13 Type 2 diabetes; CESC cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg26597838 chr10:835615 NA 1.18 11.34 0.57 1.52e-24 Eosinophil percentage of granulocytes; CESC cis rs9815354 1.000 rs9854833 chr3:41775577 C/T cg03022575 chr3:42003672 ULK4 0.53 5.21 0.3 3.81e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs12950390 0.853 rs11079790 chr17:45853626 G/A cg00777063 chr17:45855553 NA -0.39 -5.78 -0.33 2.05e-8 IgG glycosylation; CESC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg22728534 chr2:87034800 CD8A -0.45 -6.01 -0.35 6.2e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9399135 0.967 rs10872427 chr6:135353452 T/C cg22676075 chr6:135203613 NA 0.52 7.38 0.41 1.99e-12 Red blood cell count; CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -6.57 -0.37 2.71e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9916302 0.904 rs7501488 chr17:37576417 T/G cg07936489 chr17:37558343 FBXL20 -0.8 -11.36 -0.57 1.21e-24 Glomerular filtration rate (creatinine); CESC cis rs7818688 0.697 rs77055525 chr8:95980583 G/A cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9487051 0.714 rs9386797 chr6:109632520 C/A cg12927641 chr6:109611667 NA -0.37 -5.51 -0.32 8.68e-8 Reticulocyte fraction of red cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17487170 chr5:133451259 TCF7 0.44 6.42 0.37 6.37e-10 Gut microbiota (bacterial taxa); CESC cis rs8180040 0.726 rs10461018 chr3:46995242 C/T cg27129171 chr3:47204927 SETD2 -0.62 -8.78 -0.47 2.12e-16 Colorectal cancer; CESC cis rs1670533 1.000 rs7679432 chr4:1050521 G/A cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.77e-7 Recombination rate (females); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.42 -6.22 -0.36 1.88e-9 Recombination measurement; CESC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg15145296 chr3:125709740 NA -0.55 -6.33 -0.36 1.05e-9 Blood pressure (smoking interaction); CESC cis rs1577917 0.958 rs11755864 chr6:86691791 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.95 -0.34 8.33e-9 Response to antipsychotic treatment; CESC cis rs2070729 0.523 rs743562 chr5:131872383 C/T cg21138405 chr5:131827807 IRF1 -0.32 -5.4 -0.31 1.49e-7 Platelet count; CESC cis rs902774 0.554 rs4919749 chr12:53358034 C/T cg14581129 chr12:53358946 NA -0.5 -6.78 -0.38 7.91e-11 Prostate cancer; CESC trans rs61931739 0.500 rs11519398 chr12:34473553 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.5 0.54 8.77e-22 Morning vs. evening chronotype; CESC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg22800045 chr5:56110881 MAP3K1 -0.6 -7.71 -0.43 2.48e-13 Initial pursuit acceleration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19046697 chr5:92915581 FLJ42709 -0.5 -7.24 -0.41 4.93e-12 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05985655 chr5:16616805 FAM134B 0.63 7.58 0.42 6e-13 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 10.92 0.56 3.64e-23 Personality dimensions; CESC cis rs56104184 0.775 rs117016425 chr19:49400216 C/T cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs36051895 0.659 rs10283730 chr9:5073289 G/A cg02405213 chr9:5042618 JAK2 -0.5 -6.07 -0.35 4.51e-9 Pediatric autoimmune diseases; CESC cis rs4950322 0.570 rs72692904 chr1:146773136 T/A cg22381352 chr1:146742008 CHD1L -0.46 -5.05 -0.3 8.32e-7 Protein quantitative trait loci; CESC cis rs6732160 0.613 rs6546804 chr2:73385919 G/A cg01422370 chr2:73384389 NA 0.56 8.74 0.47 2.67e-16 Intelligence (multi-trait analysis); CESC cis rs3862435 0.518 rs2444061 chr15:90909439 T/G cg22089800 chr15:90895588 ZNF774 0.53 5.8 0.34 1.88e-8 Response to exercise (triglyceride level interaction); CESC cis rs523522 0.962 rs3213565 chr12:120992401 C/T cg27279351 chr12:120934652 DYNLL1 0.68 8.7 0.47 3.47e-16 High light scatter reticulocyte count; CESC trans rs61931739 0.534 rs10844732 chr12:34037104 A/C cg26384229 chr12:38710491 ALG10B 0.6 8.41 0.46 2.5e-15 Morning vs. evening chronotype; CESC cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg04972856 chr6:88032051 C6orf162;GJB7 0.34 5.53 0.32 7.5e-8 Monocyte percentage of white cells; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11832990 chr15:78832690 PSMA4 -0.54 -6.45 -0.37 5.38e-10 Ulcerative colitis; CESC trans rs7615952 0.641 rs2365019 chr3:125808135 T/C cg07211511 chr3:129823064 LOC729375 -0.56 -6.22 -0.36 1.92e-9 Blood pressure (smoking interaction); CESC cis rs367943 0.712 rs10035686 chr5:112683357 C/T cg12552261 chr5:112820674 MCC 0.41 5.3 0.31 2.49e-7 Type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14095983 chr9:71737204 TJP2 -0.48 -6.25 -0.36 1.65e-9 Ulcerative colitis; CESC cis rs72781680 0.898 rs113027486 chr2:24098371 G/A cg08917208 chr2:24149416 ATAD2B 0.91 8.38 0.46 3.17e-15 Lymphocyte counts; CESC cis rs7927592 0.763 rs624003 chr11:68231240 C/T cg01657329 chr11:68192670 LRP5 -0.47 -6.09 -0.35 3.93e-9 Total body bone mineral density; CESC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg19163074 chr7:65112434 INTS4L2 -0.43 -5.51 -0.32 8.54e-8 Aortic root size; CESC cis rs3733585 0.673 rs4312757 chr4:9956145 T/A cg11266682 chr4:10021025 SLC2A9 -0.59 -11.16 -0.57 5.9e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9987353 0.566 rs34389718 chr8:9065525 A/G cg06636001 chr8:8085503 FLJ10661 -0.59 -7.16 -0.4 7.73e-12 Recombination measurement; CESC cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.47 6.35 0.36 9.1e-10 Personality dimensions; CESC cis rs13064411 0.696 rs2399479 chr3:113227050 G/A cg18753928 chr3:113234510 CCDC52 -0.47 -5.44 -0.32 1.21e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC trans rs12542260 0.871 rs7836802 chr8:125473730 C/T cg09438698 chr12:133365205 GOLGA3 -0.49 -6.44 -0.37 5.5e-10 Colonoscopy-negative controls vs population controls; CESC cis rs651907 0.557 rs13099674 chr3:101489629 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.5 6.73 0.38 1.05e-10 Colorectal cancer; CESC trans rs35110281 0.748 rs9981460 chr21:45030965 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 7.11 0.4 1.1e-11 Mean corpuscular volume; CESC cis rs4481887 0.927 rs4558008 chr1:248477641 C/T cg00666640 chr1:248458726 OR2T12 0.35 5.79 0.34 1.95e-8 Common traits (Other); CESC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg02725872 chr8:58115012 NA -0.42 -5.85 -0.34 1.48e-8 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs12042938 0.507 rs1655301 chr1:231731730 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.53 -0.46 1.16e-15 Neuranatomic and neurocognitive phenotypes; CESC cis rs9916302 0.610 rs11078902 chr17:37631883 C/G cg20243544 chr17:37824526 PNMT 0.51 6.44 0.37 5.65e-10 Glomerular filtration rate (creatinine); CESC cis rs9494145 0.680 rs9376092 chr6:135427144 A/C cg22676075 chr6:135203613 NA -0.41 -5.12 -0.3 5.97e-7 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CESC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.0 0.56 1.99e-23 Platelet count; CESC cis rs66573146 0.831 rs56300156 chr4:6990813 G/C cg00086871 chr4:6988644 TBC1D14 1.18 7.59 0.42 5.45e-13 Granulocyte percentage of myeloid white cells; CESC cis rs868036 0.681 rs28688285 chr15:68110297 T/C cg24579218 chr15:68104479 NA -0.36 -5.07 -0.3 7.39e-7 Restless legs syndrome; CESC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg18099408 chr3:52552593 STAB1 -0.31 -5.16 -0.3 4.75e-7 Bipolar disorder; CESC cis rs2294693 0.947 rs736795 chr6:40998141 G/A cg14769373 chr6:40998127 UNC5CL -0.47 -6.6 -0.38 2.28e-10 Gastric cancer;Non-cardia gastric cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05290695 chr8:119634602 SAMD12 -0.58 -7.0 -0.4 2.15e-11 Gut microbiome composition (summer); CESC cis rs9905704 0.671 rs28709536 chr17:57008912 C/A cg12560992 chr17:57184187 TRIM37 0.62 7.8 0.43 1.47e-13 Testicular germ cell tumor; CESC cis rs11696501 0.688 rs6104247 chr20:44244938 C/T cg11783356 chr20:44313418 WFDC10B -0.35 -5.45 -0.32 1.15e-7 Brain structure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03474219 chr11:64072691 ESRRA 0.59 7.21 0.4 5.83e-12 Gut microbiome composition (summer); CESC trans rs7618501 0.633 rs9814664 chr3:50078541 C/T cg21659725 chr3:3221576 CRBN -0.49 -6.92 -0.39 3.38e-11 Intelligence (multi-trait analysis); CESC cis rs10492096 0.947 rs10849482 chr12:6635274 G/A cg13857086 chr12:6580257 VAMP1 0.56 5.44 0.32 1.23e-7 Hip geometry; CESC cis rs10129255 0.500 rs8011115 chr14:107194530 T/C cg07958169 chr14:107095056 NA -0.49 -7.38 -0.41 2.01e-12 Kawasaki disease; CESC cis rs6570726 0.935 rs409121 chr6:145839793 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.74 0.38 1e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25765325 chr7:25164994 CYCS 0.53 6.08 0.35 4.25e-9 Gut microbiome composition (summer); CESC cis rs7927771 0.524 rs2170815 chr11:47875910 T/C cg18512352 chr11:47633146 NA 0.35 5.38 0.31 1.66e-7 Subjective well-being; CESC cis rs11792861 0.781 rs72607159 chr9:111764270 C/T cg13535736 chr9:111863775 C9orf5 -0.46 -6.06 -0.35 4.65e-9 Menarche (age at onset); CESC cis rs1568889 1.000 rs34667360 chr11:28055650 T/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.7 8.15 0.45 1.44e-14 Bipolar disorder; CESC cis rs11098499 0.738 rs72918577 chr4:120326701 G/A cg09307838 chr4:120376055 NA 0.95 13.83 0.65 4.08e-33 Corneal astigmatism; CESC cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg24733560 chr20:60626293 TAF4 0.46 6.57 0.37 2.67e-10 Body mass index; CESC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg10560079 chr2:191398806 TMEM194B 0.47 6.77 0.38 8.47e-11 Pulse pressure; CESC trans rs629535 0.821 rs650267 chr8:70029160 C/T cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg02487422 chr3:49467188 NICN1 0.44 5.56 0.32 6.42e-8 Parkinson's disease; CESC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.67 -9.19 -0.49 1.22e-17 Prudent dietary pattern; CESC cis rs7772486 0.790 rs9403755 chr6:146231470 C/A cg23711669 chr6:146136114 FBXO30 -0.92 -13.36 -0.63 1.78e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs453301 0.571 rs2929305 chr8:9085217 G/A cg17143192 chr8:8559678 CLDN23 -0.47 -5.8 -0.34 1.88e-8 Joint mobility (Beighton score); CESC cis rs854765 0.505 rs2955358 chr17:17946623 A/G cg04398451 chr17:18023971 MYO15A 0.7 10.16 0.53 1.07e-20 Total body bone mineral density; CESC cis rs4835473 0.618 rs12499907 chr4:144920901 A/C cg25736465 chr4:144833511 NA -0.45 -6.79 -0.38 7.53e-11 Immature fraction of reticulocytes; CESC cis rs763014 0.931 rs7191939 chr16:630089 C/T cg00802000 chr16:706648 WDR90 -0.42 -6.37 -0.36 8.38e-10 Height; CESC cis rs733592 0.507 rs7299704 chr12:48444488 A/G cg24011408 chr12:48396354 COL2A1 0.49 8.09 0.45 2.13e-14 Plateletcrit; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg16025584 chr9:139887217 C9orf142 -0.47 -6.33 -0.36 1.05e-9 Height; CESC cis rs11048434 0.698 rs1805784 chr12:9065172 G/T cg04155231 chr12:9217510 LOC144571 0.33 5.34 0.31 2.03e-7 Sjögren's syndrome; CESC cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg20503657 chr10:835505 NA 1.07 9.91 0.52 6.79e-20 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12598048 chr15:22892705 CYFIP1 0.52 6.09 0.35 3.92e-9 Gut microbiome composition (summer); CESC cis rs5758511 0.508 rs58099562 chr22:42453772 T/C cg00645731 chr22:42541494 CYP2D7P1 0.55 7.48 0.42 1.11e-12 Birth weight; CESC cis rs921968 0.643 rs611203 chr2:219472325 G/A cg02176678 chr2:219576539 TTLL4 0.39 6.66 0.38 1.56e-10 Mean corpuscular hemoglobin concentration; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24342864 chr17:17184608 COPS3 -0.45 -6.52 -0.37 3.59e-10 Asthma; CESC cis rs7312933 0.531 rs1796380 chr12:42791543 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.5 -6.76 -0.38 8.51e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg11752832 chr7:134001865 SLC35B4 0.54 7.09 0.4 1.19e-11 Mean platelet volume; CESC cis rs8044868 0.586 rs7188962 chr16:72098962 A/G cg16558253 chr16:72132732 DHX38 -0.41 -6.44 -0.37 5.61e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg23985595 chr17:80112537 CCDC57 0.41 6.42 0.37 6.41e-10 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18091465 chr15:82551086 EFTUD1 -0.57 -6.62 -0.38 2e-10 Gut microbiome composition (summer); CESC cis rs6752107 0.967 rs56227616 chr2:234157741 T/C cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.38 5.75 0.33 2.4e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs9399135 0.636 rs4646871 chr6:135265617 A/G cg22676075 chr6:135203613 NA -0.49 -6.94 -0.39 2.92e-11 Red blood cell count; CESC cis rs854765 0.583 rs7222480 chr17:17818817 G/T cg04398451 chr17:18023971 MYO15A -0.65 -9.11 -0.49 2.08e-17 Total body bone mineral density; CESC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg06420487 chr17:61919686 SMARCD2 0.44 5.3 0.31 2.48e-7 Height; CESC cis rs2230307 0.656 rs1395332 chr1:100503993 A/C cg24955406 chr1:100503596 HIAT1 0.55 5.42 0.32 1.31e-7 Carotid intima media thickness; CESC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg24324837 chr19:49891574 CCDC155 0.52 6.07 0.35 4.32e-9 Multiple sclerosis; CESC cis rs11958404 0.860 rs6885815 chr5:157437253 C/T cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs16854884 0.632 rs1910691 chr3:143656905 G/A cg06585982 chr3:143692056 C3orf58 0.56 7.59 0.42 5.61e-13 Economic and political preferences (feminism/equality); CESC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg18876405 chr7:65276391 NA 0.53 7.06 0.4 1.42e-11 Aortic root size; CESC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.09 21.48 0.8 5.66e-60 Prudent dietary pattern; CESC cis rs752010 0.967 rs6703597 chr1:42097904 C/T cg06885757 chr1:42089581 HIVEP3 0.5 8.06 0.44 2.57e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9486719 0.857 rs3798293 chr6:97033370 A/G cg06623918 chr6:96969491 KIAA0776 -0.83 -8.97 -0.48 5.38e-17 Migraine;Coronary artery disease; CESC cis rs3806843 0.966 rs11953833 chr5:140155123 T/A cg16179182 chr5:140090404 VTRNA1-1 -0.38 -5.03 -0.3 9.03e-7 Depressive symptoms (multi-trait analysis); CESC cis rs965469 0.779 rs6515810 chr20:3370861 T/C cg25506879 chr20:3388711 C20orf194 -0.49 -5.28 -0.31 2.63e-7 IFN-related cytopenia; CESC cis rs1152591 0.811 rs1255984 chr14:64654431 C/T cg23250157 chr14:64679961 SYNE2 -0.54 -7.78 -0.43 1.67e-13 Atrial fibrillation; CESC cis rs12142240 0.698 rs66575205 chr1:46814092 T/G cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.15 0.81 2.97e-62 Prudent dietary pattern; CESC cis rs72627123 0.867 rs77321049 chr14:74455219 G/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.79 5.35 0.31 1.9e-7 Morning vs. evening chronotype; CESC cis rs6674176 0.597 rs2352990 chr1:44393276 T/A cg23954153 chr1:44402353 ARTN -0.36 -5.44 -0.32 1.24e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg11644478 chr21:40555479 PSMG1 -0.53 -7.23 -0.41 5.11e-12 Menarche (age at onset); CESC trans rs62158800 0.852 rs60010278 chr2:108270056 T/C cg20498414 chr20:43439400 RIMS4 -0.68 -6.02 -0.35 5.81e-9 Facial morphology (factor 22); CESC cis rs10751667 0.643 rs10902257 chr11:973577 T/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.32 -0.31 2.24e-7 Alzheimer's disease (late onset); CESC cis rs11711311 1.000 rs7622515 chr3:113472538 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.59 7.78 0.43 1.6e-13 IgG glycosylation; CESC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg18876405 chr7:65276391 NA 0.51 6.84 0.39 5.45e-11 Aortic root size; CESC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs6502050 0.835 rs4459614 chr17:80086597 C/T cg23985595 chr17:80112537 CCDC57 0.4 6.23 0.36 1.85e-9 Life satisfaction; CESC cis rs35851103 0.600 rs4841662 chr8:11843758 A/G cg14752069 chr8:11977206 FAM66D -0.31 -5.12 -0.3 5.94e-7 Neuroticism; CESC cis rs4780401 0.609 rs55934118 chr16:11820003 G/C cg01061890 chr16:11836724 TXNDC11 -0.55 -7.56 -0.42 6.67e-13 Rheumatoid arthritis; CESC cis rs7078219 0.543 rs10786556 chr10:101278324 C/T cg09788492 chr10:101292477 NKX2-3 0.33 6.23 0.36 1.81e-9 Dental caries; CESC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg02869306 chr7:64672164 INTS4L1 0.32 5.11 0.3 6.08e-7 Calcium levels; CESC cis rs11792861 0.781 rs874864 chr9:111728718 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 7.99 0.44 4.18e-14 Menarche (age at onset); CESC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg26314531 chr2:26401878 FAM59B 0.72 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC cis rs11696501 0.738 rs6104294 chr20:44326850 T/C cg11783356 chr20:44313418 WFDC10B -0.31 -5.08 -0.3 7.02e-7 Brain structure; CESC cis rs748404 0.578 rs2278856 chr15:43631356 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.81 0.43 1.33e-13 Lung cancer; CESC cis rs9457247 0.756 rs1811123 chr6:167403443 T/C cg23791538 chr6:167370224 RNASET2 -0.58 -8.29 -0.45 5.65e-15 Crohn's disease; CESC cis rs3749237 0.595 rs35701831 chr3:49515000 A/C cg07636037 chr3:49044803 WDR6 0.6 8.71 0.47 3.31e-16 Resting heart rate; CESC cis rs13082711 0.595 rs17317435 chr3:27339326 A/G cg02860705 chr3:27208620 NA 0.78 9.37 0.5 3.35e-18 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08240571 chr16:87970654 CA5A 0.36 6.53 0.37 3.35e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs34375054 0.624 rs73233307 chr12:125675873 G/C cg25124228 chr12:125621409 AACS -0.46 -5.24 -0.31 3.23e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs728616 0.867 rs117139504 chr10:81734207 C/A cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04297258 chr16:88772664 RNF166;CTU2 0.52 6.68 0.38 1.4e-10 Gut microbiota (bacterial taxa); CESC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg16145915 chr7:1198662 ZFAND2A 0.46 6.3 0.36 1.22e-9 Longevity;Endometriosis; CESC cis rs2652822 0.662 rs34367270 chr15:63410912 G/A cg02713581 chr15:63449717 RPS27L 0.43 5.49 0.32 9.22e-8 Metabolic traits; CESC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg02071572 chr4:1403502 NA 0.38 5.74 0.33 2.64e-8 Longevity; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13790199 chr7:100209986 MOSPD3 -0.49 -6.21 -0.36 2.02e-9 Ulcerative colitis; CESC cis rs208520 0.690 rs4386800 chr6:66755242 A/G cg07460842 chr6:66804631 NA 0.96 12.59 0.61 8.05e-29 Exhaled nitric oxide output; CESC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg21782813 chr7:2030301 MAD1L1 0.51 7.29 0.41 3.59e-12 Bipolar disorder and schizophrenia; CESC cis rs2268241 0.938 rs7283827 chr21:34769904 A/G cg14850771 chr21:34775459 IFNGR2 0.94 11.49 0.58 4.44e-25 Obesity-related traits; CESC cis rs2228479 0.850 rs62054638 chr16:89821131 G/C cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg11890956 chr21:40555474 PSMG1 1.22 24.05 0.83 1.4e-68 Cognitive function; CESC cis rs61841072 1.000 rs10803106 chr1:243129841 G/T cg02356786 chr1:243265016 LOC731275 0.41 5.26 0.31 2.97e-7 Schizophrenia; CESC cis rs1801251 1.000 rs13008942 chr2:233594875 G/A cg25237894 chr2:233734115 C2orf82 0.45 7.78 0.43 1.68e-13 Coronary artery disease; CESC cis rs1538970 0.962 rs9429075 chr1:45818421 G/A cg06784218 chr1:46089804 CCDC17 0.31 5.15 0.3 5.19e-7 Platelet count; CESC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg18252515 chr7:66147081 NA 0.46 6.03 0.35 5.53e-9 Aortic root size; CESC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg09177884 chr7:1199841 ZFAND2A -0.55 -7.03 -0.4 1.72e-11 Longevity;Endometriosis; CESC cis rs3820068 0.603 rs6660234 chr1:15962590 T/C cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.3100000000000001e-10 Systolic blood pressure; CESC cis rs11155671 0.517 rs9397058 chr6:150207249 C/T cg09699651 chr6:150184138 LRP11 0.56 7.75 0.43 2.01e-13 Testicular germ cell tumor; CESC cis rs6570726 0.935 rs110289 chr6:145865176 C/G cg23711669 chr6:146136114 FBXO30 0.8 11.78 0.59 4.84e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.88 9.62 0.51 5.45e-19 Mean platelet volume; CESC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg13770153 chr20:60521292 NA -0.5 -6.53 -0.37 3.31e-10 Body mass index; CESC cis rs2456568 0.802 rs1395387 chr11:93639307 A/T cg26875233 chr11:93583750 C11orf90 -0.31 -5.42 -0.32 1.37e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs2197308 0.813 rs11504316 chr12:38219320 G/A cg26384229 chr12:38710491 ALG10B -0.47 -6.34 -0.36 1.01e-9 Morning vs. evening chronotype; CESC cis rs9355610 0.727 rs2247315 chr6:167370211 A/C cg23791538 chr6:167370224 RNASET2 0.7 9.97 0.52 4.28e-20 Graves' disease; CESC trans rs7615952 0.688 rs12485622 chr3:125710739 T/C cg07211511 chr3:129823064 LOC729375 -0.57 -6.53 -0.37 3.29e-10 Blood pressure (smoking interaction); CESC cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg07636037 chr3:49044803 WDR6 1.04 19.28 0.76 2.27e-52 Parkinson's disease; CESC cis rs739401 0.595 rs6578305 chr11:3001120 C/T cg25174290 chr11:3078921 CARS 0.51 7.05 0.4 1.51e-11 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17492855 chr11:65585364 NA -0.6 -6.93 -0.39 3.22e-11 Gut microbiome composition (summer); CESC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg03647317 chr4:187891568 NA -0.39 -5.54 -0.32 7.26e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs2832191 0.597 rs8127842 chr21:30516461 G/A cg24692254 chr21:30365293 RNF160 -0.63 -7.77 -0.43 1.74e-13 Dental caries; CESC cis rs1552244 0.554 rs2272121 chr3:10047680 A/G cg00149659 chr3:10157352 C3orf10 0.54 6.55 0.37 2.98e-10 Alzheimer's disease; CESC cis rs12136530 0.774 rs12092284 chr1:19778323 C/T cg01832549 chr1:19774989 CAPZB -0.48 -6.78 -0.38 7.83e-11 Lead levels in blood; CESC cis rs55871839 0.598 rs4737525 chr8:59799781 G/A cg07426533 chr8:59803705 TOX -0.5 -7.16 -0.4 8.11e-12 Pneumonia; CESC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs6952808 0.931 rs12537479 chr7:1868995 A/G cg23102388 chr7:1867652 MAD1L1 0.36 5.54 0.32 7.34e-8 Bipolar disorder and schizophrenia; CESC trans rs7246657 0.943 rs4803347 chr19:37848017 G/A cg24637308 chr11:6592297 DNHD1 0.52 6.02 0.35 5.89e-9 Coronary artery calcification; CESC cis rs7192750 0.562 rs152838 chr16:72105702 C/T cg14768367 chr16:72042858 DHODH 0.74 6.17 0.35 2.57e-9 LDL cholesterol levels;Total cholesterol levels; CESC cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.76 -12.3 -0.6 8.23e-28 Personality dimensions; CESC cis rs6456156 0.742 rs2022000 chr6:167529611 A/G cg07741184 chr6:167504864 NA -0.31 -5.12 -0.3 5.75e-7 Primary biliary cholangitis; CESC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg05863683 chr7:1912471 MAD1L1 0.38 5.57 0.32 6.26e-8 Bipolar disorder and schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10640168 chr8:141360745 TRAPPC9 0.51 7.2 0.4 6.39e-12 Fibrinogen levels; CESC cis rs72781680 0.716 rs2551325 chr2:23979729 C/T cg08917208 chr2:24149416 ATAD2B 0.61 5.95 0.34 8.4e-9 Lymphocyte counts; CESC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -11.97 -0.59 1.09e-26 Alzheimer's disease; CESC cis rs2932538 0.961 rs10745332 chr1:113189053 G/A cg22162597 chr1:113214053 CAPZA1 -0.52 -6.84 -0.39 5.56e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs3762637 1.000 rs7642869 chr3:122190786 T/C cg24169773 chr3:122142474 KPNA1 -0.54 -6.33 -0.36 1.04e-9 LDL cholesterol levels; CESC cis rs11030122 0.702 rs7102215 chr11:3943970 C/T cg18678763 chr11:4115507 RRM1 -0.45 -6.05 -0.35 4.94e-9 Mean platelet volume;Platelet distribution width; CESC cis rs7131987 0.845 rs7299861 chr12:29409667 G/A cg09582351 chr12:29534625 ERGIC2 -0.35 -5.72 -0.33 2.9e-8 QT interval; CESC cis rs9649465 1.000 rs7805759 chr7:123318696 C/A cg04330084 chr7:123175371 IQUB -0.38 -5.16 -0.3 4.75e-7 Migraine; CESC cis rs12458462 0.892 rs2242175 chr18:77464406 G/A cg11879182 chr18:77439856 CTDP1 0.88 13.95 0.65 1.54e-33 Monocyte count; CESC trans rs6084875 0.641 rs2025117 chr20:4723701 A/G cg10192164 chr16:30419175 ZNF771 -0.51 -6.18 -0.35 2.44e-9 Systemic lupus erythematosus; CESC cis rs1927790 0.727 rs9556550 chr13:96947034 A/C cg02571835 chr13:96230311 CLDN10 -0.36 -5.35 -0.31 1.88e-7 Body mass index; CESC cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg10523679 chr1:76189770 ACADM 0.65 6.45 0.37 5.37e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4906332 0.811 rs2756138 chr14:103996733 C/G cg19000871 chr14:103996768 TRMT61A 0.37 5.51 0.32 8.69e-8 Coronary artery disease; CESC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.4 5.08 0.3 7.01e-7 Lymphocyte counts; CESC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg17724175 chr1:150552817 MCL1 0.33 5.08 0.3 7.16e-7 Melanoma; CESC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg12648201 chr2:27665141 KRTCAP3 -0.28 -5.41 -0.32 1.4e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs3857536 0.813 rs7771716 chr6:66946769 C/T cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs2120019 0.938 rs8030089 chr15:75290377 C/T cg11632617 chr15:75315747 PPCDC -0.47 -5.23 -0.31 3.47e-7 Blood trace element (Zn levels); CESC cis rs2795502 1.000 rs2795508 chr10:43353555 G/T cg20628663 chr10:43360327 NA 0.54 6.64 0.38 1.74e-10 Blood protein levels; CESC cis rs57502260 0.704 rs2186937 chr11:68256847 G/A cg20283391 chr11:68216788 NA -0.68 -5.69 -0.33 3.39e-8 Total body bone mineral density (age 45-60); CESC cis rs10838687 0.736 rs2633083 chr11:47249420 T/C cg25783544 chr11:47291846 MADD -0.56 -6.56 -0.37 2.78e-10 Proinsulin levels; CESC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg14893161 chr1:205819251 PM20D1 0.87 14.6 0.67 7.96e-36 Menarche (age at onset); CESC cis rs11030122 0.702 rs10835402 chr11:3990914 T/C cg18678763 chr11:4115507 RRM1 -0.46 -6.12 -0.35 3.31e-9 Mean platelet volume;Platelet distribution width; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03558408 chr5:134181967 C5orf24 -0.42 -6.08 -0.35 4.19e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3733585 0.579 rs4235356 chr4:10123106 G/C cg00071950 chr4:10020882 SLC2A9 -0.65 -10.19 -0.53 8.59e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg26335602 chr6:28129616 ZNF389 0.52 6.85 0.39 5.22e-11 Depression; CESC cis rs9937943 0.615 rs12925346 chr16:74492495 G/C cg01733217 chr16:74700730 RFWD3 0.63 5.48 0.32 1.01e-7 Neutrophil percentage of white cells; CESC cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.82e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18955698 chr17:43025023 KIF18B -0.49 -6.83 -0.39 5.92e-11 Gut microbiota (bacterial taxa); CESC cis rs3749237 0.595 rs6797765 chr3:49423976 A/G cg07636037 chr3:49044803 WDR6 0.59 8.45 0.46 1.98e-15 Resting heart rate; CESC cis rs929354 0.742 rs3808316 chr7:156944787 C/G cg05182265 chr7:156933206 UBE3C -0.5 -7.28 -0.41 3.7e-12 Body mass index; CESC cis rs7808935 0.628 rs72598551 chr7:27939885 C/T cg05786569 chr7:27702416 HIBADH 0.52 5.84 0.34 1.56e-8 Prostate cancer; CESC cis rs2370759 0.891 rs76164690 chr10:32590362 T/G cg01819863 chr10:32635814 EPC1 1.12 10.5 0.54 8.76e-22 Sexual dysfunction (female); CESC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg05564831 chr3:52568323 NT5DC2 0.45 7.06 0.4 1.5e-11 Bipolar disorder; CESC cis rs10883723 0.810 rs6584504 chr10:104253507 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.44 0.42 1.43e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs1691799 0.899 rs1168306 chr12:66738900 A/G cg16791601 chr12:66731901 HELB -0.75 -12.98 -0.62 3.8e-30 White blood cell count (basophil); CESC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg19257562 chr1:2043853 PRKCZ 0.34 5.71 0.33 3.02e-8 Height; CESC cis rs9309473 0.555 rs2901437 chr2:73597024 T/G cg20560298 chr2:73613845 ALMS1 -0.46 -6.55 -0.37 3.03e-10 Metabolite levels; CESC cis rs1707322 0.752 rs61784798 chr1:46173481 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs4716602 0.550 rs12672151 chr7:156159053 A/G cg07175507 chr18:77160758 NFATC1 -0.44 -6.09 -0.35 3.91e-9 Anti-saccade response; CESC cis rs10771431 0.817 rs17202253 chr12:9361850 A/G cg08997352 chr12:9597637 DDX12 -0.75 -10.14 -0.53 1.24e-20 Breast size; CESC cis rs7252981 0.632 rs880090 chr19:19740729 C/G cg03709012 chr19:19516395 GATAD2A 0.45 5.21 0.3 3.79e-7 Perceived unattractiveness to mosquitoes; CESC cis rs523522 0.962 rs11065149 chr12:120956963 G/A cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03934443 chr10:134639821 NA -0.48 -6.58 -0.37 2.45e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -5.53 -0.32 7.62e-8 Personality dimensions; CESC cis rs8141529 0.764 rs5752809 chr22:29225500 G/A cg15103426 chr22:29168792 CCDC117 0.68 9.65 0.51 4.52e-19 Lymphocyte counts; CESC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg10560079 chr2:191398806 TMEM194B 0.49 7.03 0.4 1.8e-11 Pulse pressure; CESC cis rs694739 0.541 rs61886926 chr11:64133552 C/T cg23796481 chr11:64053134 BAD;GPR137 0.56 6.87 0.39 4.63e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg03709012 chr19:19516395 GATAD2A -0.96 -14.2 -0.66 2.12e-34 Tonsillectomy; CESC cis rs926938 0.563 rs360652 chr1:115445478 C/T cg12756093 chr1:115239321 AMPD1 0.48 6.94 0.39 3e-11 Autism; CESC cis rs8077577 0.836 rs58441148 chr17:18106498 T/A cg16794390 chr17:18148240 FLII 0.41 5.59 0.32 5.53e-8 Obesity-related traits; CESC cis rs2072732 0.861 rs1890338 chr1:2949028 C/T cg03976712 chr1:2946727 NA 0.34 5.63 0.33 4.53e-8 Plateletcrit; CESC cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg23158103 chr7:148848205 ZNF398 -0.4 -6.36 -0.36 8.78e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4523957 0.559 rs216174 chr17:2164898 A/G cg16513277 chr17:2031491 SMG6 0.52 5.64 0.33 4.43e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9815354 1.000 rs2683695 chr3:41914928 C/T cg03022575 chr3:42003672 ULK4 0.44 5.13 0.3 5.55e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs858239 0.600 rs2072369 chr7:23146189 A/G cg23682824 chr7:23144976 KLHL7 0.55 7.79 0.43 1.49e-13 Cerebrospinal fluid biomarker levels; CESC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg06456125 chr7:65229604 NA -0.39 -5.1 -0.3 6.54e-7 Aortic root size; CESC cis rs644799 0.965 rs10831430 chr11:95509638 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.37 0.5 3.25e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1707322 1.000 rs3922887 chr1:46473802 A/G cg06784218 chr1:46089804 CCDC17 0.34 5.75 0.33 2.49e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7837860 0.588 rs28986511 chr8:89295258 G/A cg04391754 chr17:18022714 MYO15A 0.52 6.07 0.35 4.4e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2625529 0.617 rs2306576 chr15:72170686 C/T cg16672083 chr15:72433130 SENP8 0.47 7.19 0.4 6.81e-12 Red blood cell count; CESC cis rs9549260 0.664 rs1360719 chr13:41225874 G/C cg21288729 chr13:41239152 FOXO1 0.66 8.55 0.47 9.85e-16 Red blood cell count; CESC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg02353165 chr6:42928485 GNMT 0.86 14.33 0.66 7.06e-35 Alzheimer's disease in APOE e4+ carriers; CESC cis rs78456975 0.527 rs10203194 chr2:1558021 A/G cg26248373 chr2:1572462 NA -0.57 -6.79 -0.39 7.14e-11 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs3820068 0.532 rs74057713 chr1:15944620 G/C cg17385448 chr1:15911702 AGMAT 0.41 6.82 0.39 5.97e-11 Systolic blood pressure; CESC cis rs116095464 0.558 rs73024831 chr5:257192 A/G cg20965017 chr5:231967 SDHA -0.47 -5.22 -0.31 3.61e-7 Breast cancer; CESC trans rs12681287 0.517 rs34367154 chr8:87508749 A/T cg27317242 chr8:23145699 R3HCC1 -0.53 -6.35 -0.36 9.05e-10 Caudate activity during reward; CESC cis rs3768617 0.510 rs10911247 chr1:183076993 A/G ch.1.3577855R chr1:183094577 LAMC1 0.82 12.37 0.6 4.91e-28 Fuchs's corneal dystrophy; CESC cis rs6840258 0.800 rs6839933 chr4:87964363 A/C cg08197287 chr4:87952173 AFF1 -0.35 -5.18 -0.3 4.45e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs7662987 0.517 rs2602876 chr4:100039535 A/T cg13256891 chr4:100009986 ADH5 0.7 7.59 0.42 5.63e-13 Smoking initiation; CESC trans rs2823962 0.759 rs2211990 chr21:18016965 G/A cg06419850 chr17:4688683 VMO1 -0.42 -6.13 -0.35 3.23e-9 Amyotrophic lateral sclerosis; CESC cis rs9902453 0.904 rs12952179 chr17:28412687 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.71 -9.11 -0.49 2.13e-17 Coffee consumption (cups per day); CESC cis rs4332037 0.530 rs62434669 chr7:1866946 G/A cg13880726 chr7:1868755 MAD1L1 -0.52 -5.17 -0.3 4.52e-7 Bipolar disorder; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05062148 chr1:25757186 TMEM57 -0.47 -6.2 -0.36 2.15e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs561341 1.000 rs72825712 chr17:30316119 A/T cg20587970 chr11:113659929 NA -1.48 -19.48 -0.77 4.55e-53 Hip circumference adjusted for BMI; CESC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg17376030 chr22:41985996 PMM1 0.67 7.27 0.41 3.96e-12 Vitiligo; CESC cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg24209194 chr3:40518798 ZNF619 0.51 6.64 0.38 1.74e-10 Renal cell carcinoma; CESC cis rs2249694 1.000 rs1952467 chr10:135353499 T/G cg20169779 chr10:135381914 SYCE1 0.39 5.2 0.3 3.9e-7 Obesity-related traits; CESC cis rs10504229 0.679 rs72649119 chr8:58040301 T/C cg24829409 chr8:58192753 C8orf71 -0.5 -6.25 -0.36 1.61e-9 Developmental language disorder (linguistic errors); CESC cis rs4964805 0.632 rs11111782 chr12:104188476 A/G cg02344784 chr12:104178138 NT5DC3 -0.48 -6.91 -0.39 3.64e-11 Attention deficit hyperactivity disorder; CESC cis rs929596 0.755 rs4148325 chr2:234673309 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.69 -9.23 -0.49 8.92e-18 Total bilirubin levels in HIV-1 infection; CESC cis rs7914558 1.000 rs7094843 chr10:104806654 A/C cg08650961 chr10:104748594 CNNM2 0.31 5.19 0.3 4.18e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2760061 0.598 rs658238 chr1:228121291 A/G cg01973587 chr1:228161476 NA 0.37 5.73 0.33 2.77e-8 Diastolic blood pressure; CESC cis rs16854884 0.632 rs1466941 chr3:143670131 A/G cg06585982 chr3:143692056 C3orf58 0.56 7.53 0.42 8.21e-13 Economic and political preferences (feminism/equality); CESC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC cis rs73206853 0.841 rs7967246 chr12:110756569 G/A cg12870014 chr12:110450643 ANKRD13A 0.64 5.06 0.3 7.92e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg18337363 chr3:52569053 NT5DC2 0.29 5.27 0.31 2.85e-7 Bipolar disorder; CESC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.03 0.4 1.78e-11 Height; CESC cis rs2841277 0.741 rs9672139 chr14:105408182 T/G cg19901468 chr14:105411992 AHNAK2 -0.65 -9.71 -0.51 2.88e-19 Rheumatoid arthritis; CESC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg16145915 chr7:1198662 ZFAND2A -0.51 -6.35 -0.36 9.13e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02079963 chr6:160512064 IGF2R -0.6 -7.05 -0.4 1.58e-11 Gut microbiome composition (summer); CESC cis rs2050392 0.517 rs2489847 chr10:30743673 G/A cg18806716 chr10:30721971 MAP3K8 -0.5 -7.64 -0.42 3.9e-13 Inflammatory bowel disease; CESC cis rs4268898 0.662 rs2303297 chr2:24432937 C/T cg06627628 chr2:24431161 ITSN2 -1.02 -11.2 -0.57 4.2e-24 Asthma; CESC cis rs2797685 0.773 rs2301489 chr1:7837676 G/C cg04725166 chr1:7887271 PER3 -0.39 -5.37 -0.31 1.71e-7 Crohn's disease; CESC cis rs2651899 0.934 rs1627080 chr1:3081309 T/C cg22674798 chr1:3096360 PRDM16 0.42 8.31 0.45 5.02e-15 Migraine; CESC cis rs7100689 0.784 rs10887838 chr10:82161380 G/A cg00277334 chr10:82204260 NA -0.59 -7.32 -0.41 3.05e-12 Post bronchodilator FEV1; CESC cis rs35160687 0.623 rs4832263 chr2:86485157 G/T cg01119172 chr2:86362222 SNORD94;PTCD3 -0.37 -5.07 -0.3 7.54e-7 Night sleep phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07565404 chr2:107084911 RGPD3 -0.56 -6.66 -0.38 1.56e-10 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs12452509 chr17:37574722 G/A cg07936489 chr17:37558343 FBXL20 -0.8 -11.5 -0.58 4.2e-25 Glomerular filtration rate (creatinine); CESC cis rs6088580 0.634 rs6059880 chr20:33088669 G/A cg08999081 chr20:33150536 PIGU 0.65 11.4 0.57 9e-25 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17621259 chr3:37035168 MLH1;EPM2AIP1 0.59 6.35 0.36 9.39e-10 Gut microbiome composition (summer); CESC cis rs863345 0.604 rs10908657 chr1:158465243 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.9 -0.39 3.93e-11 Pneumococcal bacteremia; CESC cis rs8180040 0.593 rs4018905 chr3:47138170 A/G cg27129171 chr3:47204927 SETD2 0.66 9.84 0.52 1.1e-19 Colorectal cancer; CESC cis rs4604732 0.631 rs80319072 chr1:247626835 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7520050 0.931 rs6698247 chr1:46371486 C/T cg03146154 chr1:46216737 IPP -0.48 -6.34 -0.36 1e-9 Red blood cell count;Reticulocyte count; CESC cis rs11098499 0.954 rs12506546 chr4:120301618 T/C cg24375607 chr4:120327624 NA 0.46 5.58 0.32 5.79e-8 Corneal astigmatism; CESC cis rs7917772 0.503 rs10883732 chr10:104293461 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.41 0.41 1.67e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2066819 1.000 rs76430365 chr12:56699993 A/C cg26734620 chr12:56694298 CS 1.03 6.25 0.36 1.65e-9 Psoriasis vulgaris; CESC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9916302 0.904 rs8065963 chr17:37681332 C/T cg00129232 chr17:37814104 STARD3 -0.56 -7.37 -0.41 2.15e-12 Glomerular filtration rate (creatinine); CESC cis rs6701037 0.555 rs10912899 chr1:175120715 C/T cg08873628 chr1:175162347 KIAA0040 0.43 5.54 0.32 7.28e-8 Alcohol dependence; CESC cis rs2370759 1.000 rs75984055 chr10:32591276 T/C cg05361325 chr10:32636312 EPC1 -0.55 -5.18 -0.3 4.39e-7 Sexual dysfunction (female); CESC cis rs3106136 0.967 rs8026 chr4:95212185 A/G cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.73 -0.38 1.02e-10 Capecitabine sensitivity; CESC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg22535103 chr8:58192502 C8orf71 -0.9 -9.52 -0.5 1.13e-18 Developmental language disorder (linguistic errors); CESC cis rs9297145 0.565 rs12705030 chr7:98765041 A/G cg05967295 chr7:98741636 SMURF1 -0.61 -8.22 -0.45 9.3e-15 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.98 12.04 0.59 6.29e-27 Platelet count; CESC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg11214544 chr1:2391121 NA -0.4 -6.52 -0.37 3.5e-10 Schizophrenia; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg10221240 chr4:1004669 FGFRL1 0.5 6.25 0.36 1.67e-9 Attention deficit hyperactivity disorder; CESC cis rs2180341 0.960 rs1964130 chr6:127677391 C/G cg27446573 chr6:127587934 RNF146 0.97 13.1 0.63 1.47e-30 Breast cancer; CESC cis rs8017423 0.935 rs3742668 chr14:90767759 G/A cg14092571 chr14:90743983 NA 0.53 7.94 0.44 5.81e-14 Mortality in heart failure; CESC cis rs1005277 0.522 rs200943 chr10:38148730 A/G cg25427524 chr10:38739819 LOC399744 -0.68 -10.16 -0.53 1.05e-20 Extrinsic epigenetic age acceleration; CESC cis rs1045714 0.895 rs4721866 chr7:2643341 G/A cg20813462 chr7:2646259 IQCE 0.63 5.55 0.32 6.94e-8 Urate levels in lean individuals; CESC cis rs8072100 0.676 rs7221345 chr17:45405144 G/A cg25173405 chr17:45401733 C17orf57 -0.49 -6.41 -0.37 6.71e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9911578 0.967 rs405684 chr17:56777148 T/C cg05425664 chr17:57184151 TRIM37 -0.51 -7.15 -0.4 8.36e-12 Intelligence (multi-trait analysis); CESC cis rs9300255 0.602 rs1051431 chr12:123645803 G/A cg05973401 chr12:123451056 ABCB9 0.5 5.81 0.34 1.79e-8 Neutrophil percentage of white cells; CESC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.04 -0.3 8.58e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg18076651 chr12:53625605 RARG -0.5 -6.66 -0.38 1.56e-10 Lung cancer in ever smokers; CESC cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg11742103 chr11:62369870 EML3;MTA2 0.65 10.01 0.52 3.3e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg06636001 chr8:8085503 FLJ10661 -0.56 -7.33 -0.41 2.73e-12 Neuroticism; CESC trans rs526821 0.532 rs578067 chr11:55313690 T/G cg15704280 chr7:45808275 SEPT13 -0.52 -6.37 -0.36 8.32e-10 Pediatric bone mineral density (spine); CESC cis rs2074585 0.806 rs8033813 chr15:90999715 A/T cg22089800 chr15:90895588 ZNF774 0.65 8.76 0.47 2.32e-16 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg25517755 chr10:38738941 LOC399744 -0.45 -5.88 -0.34 1.25e-8 Extrinsic epigenetic age acceleration; CESC cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.57 7.01 0.4 1.98e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs35110281 0.805 rs4818843 chr21:45006607 C/T cg21573476 chr21:45109991 RRP1B -0.42 -5.62 -0.33 4.84e-8 Mean corpuscular volume; CESC cis rs1152591 0.543 rs1152592 chr14:64676098 A/G cg23250157 chr14:64679961 SYNE2 0.47 6.65 0.38 1.65e-10 Atrial fibrillation; CESC cis rs6964587 0.743 rs33993294 chr7:91998655 A/C cg17063962 chr7:91808500 NA 0.57 7.39 0.41 1.91e-12 Breast cancer; CESC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg21724239 chr8:58056113 NA 0.56 5.96 0.34 8.22e-9 Developmental language disorder (linguistic errors); CESC cis rs7084402 0.902 rs1582826 chr10:60297175 C/T cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.35e-18 Refractive error; CESC cis rs6502050 0.842 rs6502053 chr17:80066714 C/T cg11859384 chr17:80120422 CCDC57 0.4 5.51 0.32 8.47e-8 Life satisfaction; CESC cis rs4835473 0.618 rs7666297 chr4:144920158 G/A cg25736465 chr4:144833511 NA -0.45 -6.63 -0.38 1.91e-10 Immature fraction of reticulocytes; CESC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs916888 0.610 rs199529 chr17:44837217 A/C cg01570182 chr17:44337453 NA 0.76 9.84 0.52 1.11e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12476592 0.602 rs6546007 chr2:63724795 C/T cg17519650 chr2:63277830 OTX1 -0.47 -5.4 -0.31 1.46e-7 Childhood ear infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26074535 chr5:134094528 DDX46 -0.57 -6.29 -0.36 1.32e-9 Gut microbiome composition (summer); CESC cis rs6963495 0.818 rs55794529 chr7:105165747 T/C cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC trans rs7980799 0.711 rs1482993 chr12:33594515 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.09 -0.45 2.22e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs7829975 0.514 rs2920991 chr8:8259117 T/A cg08975724 chr8:8085496 FLJ10661 0.41 5.25 0.31 3.19e-7 Mood instability; CESC cis rs9828933 0.938 rs3816157 chr3:63999322 G/A cg16258503 chr3:63850278 ATXN7;THOC7 -0.66 -6.4 -0.37 7.22e-10 Type 2 diabetes; CESC cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg16339924 chr4:17578868 LAP3 0.6 7.47 0.42 1.16e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8064299 1.000 rs8064299 chr17:72762646 C/A cg25054828 chr17:72772726 NAT9;TMEM104 0.61 8.6 0.47 6.99e-16 Monocyte count; CESC trans rs57221529 0.608 rs11749927 chr5:668842 C/T cg25482853 chr8:67687455 SGK3 0.92 9.88 0.52 8.33e-20 Lung disease severity in cystic fibrosis; CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg18099408 chr3:52552593 STAB1 -0.34 -6.18 -0.35 2.39e-9 Bipolar disorder; CESC cis rs854765 0.583 rs11650890 chr17:17790882 C/T cg16928487 chr17:17741425 SREBF1 0.61 10.65 0.55 2.82e-22 Total body bone mineral density; CESC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.54 0.37 3.2e-10 Bipolar disorder; CESC cis rs2050392 0.517 rs602966 chr10:30755853 C/T cg18806716 chr10:30721971 MAP3K8 -0.51 -7.76 -0.43 1.9e-13 Inflammatory bowel disease; CESC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg12379764 chr21:47803548 PCNT 0.48 5.64 0.33 4.36e-8 Testicular germ cell tumor; CESC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg01448562 chr3:133502909 NA -0.42 -5.87 -0.34 1.27e-8 Iron status biomarkers; CESC cis rs7116495 1.000 rs10751190 chr11:71680757 C/T cg10381502 chr11:71823885 C11orf51 -0.68 -5.67 -0.33 3.64e-8 Severe influenza A (H1N1) infection; CESC cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg01579765 chr21:45077557 HSF2BP -0.57 -9.85 -0.52 1.05e-19 Mean corpuscular volume; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg09529150 chr10:22615839 BMI1 0.38 6.07 0.35 4.29e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1178968 0.901 rs9784947 chr7:72748888 C/G cg25889504 chr7:72793014 NA 0.47 5.03 0.3 8.91e-7 Triglyceride levels; CESC cis rs8114671 0.562 rs3818273 chr20:33509275 G/A cg24642439 chr20:33292090 TP53INP2 0.43 5.19 0.3 4.19e-7 Height; CESC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg10053473 chr17:62856997 LRRC37A3 0.67 7.42 0.41 1.61e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.98 -0.34 7.07e-9 Total body bone mineral density; CESC cis rs62432291 0.681 rs385438 chr6:159656213 A/G cg14500486 chr6:159655392 FNDC1 -0.62 -6.72 -0.38 1.08e-10 Joint mobility (Beighton score); CESC cis rs6728642 1.000 rs11890407 chr2:97621647 G/C cg26665480 chr2:98280029 ACTR1B -0.72 -6.69 -0.38 1.29e-10 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs7296418 0.885 rs1051434 chr12:123641200 C/T cg00376283 chr12:123451042 ABCB9 0.68 9.47 0.5 1.67e-18 Platelet count; CESC cis rs17253792 0.822 rs28681420 chr14:56088403 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg02951883 chr7:2050386 MAD1L1 -0.5 -6.71 -0.38 1.19e-10 Bipolar disorder and schizophrenia; CESC cis rs17826219 0.500 rs61685770 chr17:29085713 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Body mass index; CESC cis rs2880765 0.835 rs12708553 chr15:86046833 C/G cg19183879 chr15:85880815 NA 0.26 5.27 0.31 2.82e-7 Coronary artery disease; CESC cis rs7818688 0.697 rs74633235 chr8:95981476 A/G cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs2072732 0.904 rs2993480 chr1:2973322 A/G cg15211996 chr1:2936768 ACTRT2 -0.34 -6.12 -0.35 3.33e-9 Plateletcrit; CESC cis rs3011225 0.691 rs3791102 chr1:44366617 C/T cg12908607 chr1:44402522 ARTN -0.47 -6.94 -0.39 3e-11 Amyotrophic lateral sclerosis (age of onset); CESC cis rs2882667 0.929 rs17207828 chr5:138299835 A/G cg04439458 chr5:138467593 SIL1 -0.39 -6.18 -0.36 2.34e-9 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05384275 chr12:56122970 CD63 0.55 6.29 0.36 1.3e-9 Gut microbiome composition (summer); CESC cis rs12477438 0.798 rs6740035 chr2:99576578 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.22 -0.53 6.79e-21 Chronic sinus infection; CESC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg23172400 chr8:95962367 TP53INP1 -0.42 -8.94 -0.48 6.87e-17 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27571405 chr3:100211424 TMEM45A 0.48 6.2 0.36 2.13e-9 Gut microbiota (bacterial taxa); CESC cis rs8017423 0.967 rs59980414 chr14:90687738 G/C cg14092571 chr14:90743983 NA -0.57 -8.29 -0.45 5.91e-15 Mortality in heart failure; CESC cis rs9914988 0.778 rs4794837 chr17:27110024 T/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04101267 chr1:95538294 ALG14 -0.49 -6.04 -0.35 5.21e-9 Ulcerative colitis; CESC cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg13147721 chr7:65941812 NA -0.95 -9.01 -0.48 4.17e-17 Diabetic kidney disease; CESC trans rs9929218 1.000 rs12599517 chr16:68814590 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.22 -0.45 9.14e-15 Colorectal cancer; CESC cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg22875332 chr1:76189707 ACADM 0.63 7.38 0.41 2.06e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10493773 0.862 rs12075929 chr1:86248138 A/C cg17807903 chr1:86174739 ZNHIT6 0.4 5.35 0.31 1.88e-7 Urate levels in overweight individuals; CESC cis rs3820928 0.692 rs17416354 chr2:227770844 A/G cg11843606 chr2:227700838 RHBDD1 -0.58 -8.05 -0.44 2.81e-14 Pulmonary function; CESC cis rs2576037 0.796 rs2576041 chr18:44580919 C/T cg19077165 chr18:44547161 KATNAL2 0.51 7.11 0.4 1.05e-11 Personality dimensions; CESC cis rs6545883 0.811 rs778753 chr2:61780200 T/A cg15711740 chr2:61764176 XPO1 -0.39 -5.06 -0.3 7.81e-7 Tuberculosis; CESC trans rs11098499 0.863 rs7664986 chr4:120429952 A/C cg25214090 chr10:38739885 LOC399744 0.71 9.72 0.51 2.69e-19 Corneal astigmatism; CESC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg08109568 chr15:31115862 NA 0.66 9.3 0.5 5.39e-18 Huntington's disease progression; CESC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg07701084 chr6:150067640 NUP43 0.47 6.55 0.37 3.03e-10 Lung cancer; CESC cis rs6700559 0.740 rs6663322 chr1:200649869 G/A cg07804481 chr1:200639085 DDX59 0.39 5.06 0.3 7.88e-7 Coronary artery disease; CESC cis rs7208859 0.524 rs73263982 chr17:28920624 T/C cg14008862 chr17:28927542 LRRC37B2 0.69 6.16 0.35 2.63e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg22029157 chr1:209979665 IRF6 0.75 8.93 0.48 7.38e-17 Cleft lip with or without cleft palate; CESC cis rs7208859 0.623 rs1061342 chr17:29114463 G/A cg19761014 chr17:28927070 LRRC37B2 0.78 6.41 0.37 6.74e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2320614 0.648 rs1382661 chr4:164104090 C/T cg15586945 chr4:164088095 NAF1 -0.6 -7.87 -0.44 9.17e-14 Lung adenocarcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15600365 chr17:1420230 LOC100306951;INPP5K 0.57 6.25 0.36 1.67e-9 Gut microbiome composition (summer); CESC cis rs6964587 1.000 rs2301559 chr7:91746727 T/C cg17063962 chr7:91808500 NA 0.58 8.02 0.44 3.33e-14 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23226134 chr1:11866389 CLCN6;MTHFR -0.57 -6.72 -0.38 1.12e-10 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13765646 chr4:47708509 CORIN -0.47 -6.15 -0.35 2.8e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4466137 0.953 rs1585153 chr5:83000385 A/T cg16102102 chr5:83017553 HAPLN1 -0.47 -6.74 -0.38 9.88e-11 Prostate cancer; CESC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg27535305 chr1:53392650 SCP2 0.35 6.23 0.36 1.78e-9 Monocyte count; CESC cis rs9303401 0.614 rs34683543 chr17:56520036 C/A cg12560992 chr17:57184187 TRIM37 0.5 5.07 0.3 7.47e-7 Cognitive test performance; CESC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg13114125 chr14:105738426 BRF1 -0.9 -11.3 -0.57 1.99e-24 Mean platelet volume;Platelet distribution width; CESC cis rs2012796 0.743 rs61986598 chr14:81856865 G/A cg02996355 chr14:81879375 NA 0.64 7.93 0.44 6.28e-14 Night sleep phenotypes; CESC cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg15017067 chr4:17643749 FAM184B 0.36 5.16 0.3 4.78e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00716675 chr1:38478417 UTP11L 0.61 6.56 0.37 2.88e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.592 rs5758427 chr22:42099688 A/G cg17376030 chr22:41985996 PMM1 -0.72 -7.68 -0.43 3.15e-13 Vitiligo; CESC cis rs9788682 1.000 rs12438181 chr15:78812098 G/A cg24631222 chr15:78858424 CHRNA5 0.71 8.74 0.47 2.69e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg19163074 chr7:65112434 INTS4L2 0.42 5.28 0.31 2.63e-7 Aortic root size; CESC cis rs6598955 0.543 rs4585968 chr1:26535146 G/A cg04990556 chr1:26633338 UBXN11 0.81 9.12 0.49 1.92e-17 Obesity-related traits; CESC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg11644478 chr21:40555479 PSMG1 0.99 15.3 0.68 2.73e-38 Cognitive function; CESC cis rs9291683 0.530 rs4235346 chr4:9945296 C/T cg02734326 chr4:10020555 SLC2A9 -0.47 -6.88 -0.39 4.28e-11 Bone mineral density; CESC cis rs7210086 0.606 rs72849437 chr17:70631124 T/C cg04206342 chr17:70636940 NA -0.39 -6.18 -0.35 2.45e-9 Ulcerative colitis; CESC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg07395648 chr5:131743802 NA 0.42 5.56 0.32 6.71e-8 Breast cancer; CESC cis rs9815354 0.627 rs115971784 chr3:42016146 T/C cg03022575 chr3:42003672 ULK4 0.74 6.64 0.38 1.79e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg20243544 chr17:37824526 PNMT 0.48 5.99 0.35 6.77e-9 Glomerular filtration rate (creatinine); CESC cis rs2197308 0.667 rs61920838 chr12:37856814 T/C cg26384229 chr12:38710491 ALG10B -0.54 -7.84 -0.43 1.12e-13 Morning vs. evening chronotype; CESC cis rs68170813 0.559 rs75313693 chr7:106863170 T/C cg02696742 chr7:106810147 HBP1 -0.52 -5.09 -0.3 6.89e-7 Coronary artery disease; CESC cis rs7336332 0.628 rs9581854 chr13:28017782 C/T cg22138327 chr13:27999177 GTF3A 0.62 5.66 0.33 3.95e-8 Weight; CESC cis rs2204008 0.902 rs11520218 chr12:38223227 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.63 0.55 3.35e-22 Bladder cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24485466 chr1:200589999 KIF14 0.47 6.48 0.37 4.46e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg06634786 chr22:41940651 POLR3H -0.69 -7.19 -0.4 6.63e-12 Vitiligo; CESC cis rs113835537 0.529 rs11227515 chr11:66287383 C/T cg22134325 chr11:66188745 NPAS4 0.34 5.42 0.32 1.36e-7 Airway imaging phenotypes; CESC cis rs4268898 0.636 rs72787385 chr2:24585820 G/A cg20701182 chr2:24300061 SF3B14 0.66 6.97 0.39 2.47e-11 Asthma; CESC cis rs3806843 0.735 rs801189 chr5:140063091 A/G cg16179182 chr5:140090404 VTRNA1-1 0.39 5.11 0.3 6.21e-7 Depressive symptoms (multi-trait analysis); CESC cis rs11098499 0.657 rs71614442 chr4:120379346 C/T cg09307838 chr4:120376055 NA 0.95 13.8 0.65 5e-33 Corneal astigmatism; CESC cis rs9818758 0.505 rs11716159 chr3:49631585 G/A cg00383909 chr3:49044727 WDR6 0.81 5.35 0.31 1.9e-7 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC trans rs17685 0.725 rs2302436 chr7:75676988 A/T cg19862616 chr7:65841803 NCRNA00174 -0.86 -12.65 -0.61 4.99e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs1691799 0.899 rs1168305 chr12:66738714 A/G cg16791601 chr12:66731901 HELB -0.75 -13.03 -0.62 2.51e-30 White blood cell count (basophil); CESC cis rs9527 0.590 rs12415388 chr10:104796345 T/C cg04362960 chr10:104952993 NT5C2 0.42 5.45 0.32 1.17e-7 Arsenic metabolism; CESC cis rs17376456 0.877 rs9314099 chr5:93447375 T/C cg21475434 chr5:93447410 FAM172A 0.82 7.56 0.42 6.81e-13 Diabetic retinopathy; CESC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.66 0.81 5.75e-64 Prudent dietary pattern; CESC cis rs6460942 0.597 rs10273045 chr7:12519371 T/C cg20607287 chr7:12443886 VWDE -0.63 -7.11 -0.4 1.1e-11 Coronary artery disease; CESC cis rs8018808 0.935 rs4223 chr14:77893276 A/G cg20045696 chr14:77926864 AHSA1 -0.41 -5.69 -0.33 3.28e-8 Myeloid white cell count; CESC cis rs2243480 0.908 rs1532573 chr7:65798802 A/G cg13147721 chr7:65941812 NA 0.95 8.98 0.48 5.3e-17 Diabetic kidney disease; CESC cis rs2439831 0.681 rs7175434 chr15:43628542 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.22 0.63 5.55e-31 Lung cancer in ever smokers; CESC cis rs6460942 0.818 rs116613169 chr7:12234669 T/C cg06484146 chr7:12443880 VWDE -0.64 -6.3 -0.36 1.22e-9 Coronary artery disease; CESC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs1729951 0.575 rs361243 chr3:136697786 C/T cg03617693 chr3:136751559 NA 0.39 5.43 0.32 1.28e-7 Neuroticism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14558639 chr19:35760677 USF2 -0.46 -6.22 -0.36 1.93e-9 Fibrinogen levels; CESC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.62 0.47 6.27e-16 Bipolar disorder; CESC cis rs7927592 0.956 rs12274114 chr11:68255577 A/C cg20283391 chr11:68216788 NA -0.53 -6.41 -0.37 6.5e-10 Total body bone mineral density; CESC trans rs354225 0.539 rs13428703 chr2:54960680 G/A cg26336731 chr22:42016984 XRCC6;PPPDE2 -0.64 -6.0 -0.35 6.34e-9 Schizophrenia; CESC cis rs7553864 0.667 rs6576866 chr1:87601471 T/C cg17420885 chr1:87600446 LOC339524 -0.42 -5.68 -0.33 3.47e-8 Smoking behavior; CESC trans rs208520 0.661 rs150263 chr6:66777620 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -12.48 -0.61 2.03e-28 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25418777 chr20:44035099 DBNDD2;SYS1-DBNDD2 0.52 6.21 0.36 2.07e-9 Gut microbiome composition (summer); CESC cis rs7824557 0.806 rs6601573 chr8:11094751 A/G cg21775007 chr8:11205619 TDH -0.36 -5.24 -0.31 3.22e-7 Retinal vascular caliber; CESC cis rs12476592 0.602 rs174485 chr2:63857402 G/A cg17519650 chr2:63277830 OTX1 -0.45 -5.1 -0.3 6.61e-7 Childhood ear infection; CESC cis rs5753618 0.583 rs2899164 chr22:31790289 G/A cg13145458 chr22:31556086 RNF185 -0.5 -5.91 -0.34 1.02e-8 Colorectal cancer; CESC cis rs2832191 0.692 rs2245517 chr21:30357968 C/T cg24692254 chr21:30365293 RNF160 0.97 17.47 0.73 5.36e-46 Dental caries; CESC cis rs1577917 0.958 rs2225754 chr6:86449698 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -6.76 -0.38 8.98e-11 Response to antipsychotic treatment; CESC cis rs9326248 0.530 rs2000616 chr11:116916529 C/T cg01368799 chr11:117014884 PAFAH1B2 0.56 5.18 0.3 4.38e-7 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00919016 chr7:139168487 KLRG2 0.48 6.06 0.35 4.58e-9 Gut microbiome composition (summer); CESC cis rs763014 0.898 rs4984897 chr16:632180 G/C cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC cis rs478304 0.580 rs11606947 chr11:65508237 A/C cg10518572 chr11:65560635 OVOL1 -0.32 -6.19 -0.36 2.31e-9 Acne (severe); CESC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg22920501 chr2:26401640 FAM59B -0.86 -10.21 -0.53 7.23e-21 Gut microbiome composition (summer); CESC trans rs2235573 0.517 rs4821727 chr22:38393423 C/A cg19894588 chr14:64061835 NA 0.55 7.03 0.4 1.77e-11 Glioblastoma;Glioma; CESC cis rs3793683 0.520 rs12769959 chr10:134579026 A/C cg26818010 chr10:134567672 INPP5A -0.86 -10.62 -0.55 3.5e-22 Migraine; CESC cis rs12478296 0.591 rs7573042 chr2:242996589 A/G cg06360820 chr2:242988706 NA -0.57 -7.78 -0.43 1.66e-13 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24780086 chr5:14713043 ANKH 0.47 6.76 0.38 8.71e-11 Fibrinogen levels; CESC cis rs4780401 0.567 rs12920377 chr16:11781582 A/C cg01061890 chr16:11836724 TXNDC11 -0.43 -5.57 -0.32 6.29e-8 Rheumatoid arthritis; CESC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg02038168 chr22:39784481 NA -0.63 -6.78 -0.38 7.83e-11 IgG glycosylation; CESC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg12412775 chr1:25698385 RHCE -0.33 -6.03 -0.35 5.42e-9 Erythrocyte sedimentation rate; CESC cis rs4253772 0.550 rs6007779 chr22:46678615 A/C cg07012999 chr22:46692446 CN5H6.4;GTSE1 0.5 5.21 0.3 3.88e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.51e-7 Life satisfaction; CESC cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg10556349 chr10:835070 NA 0.54 5.77 0.33 2.17e-8 Eosinophil percentage of granulocytes; CESC cis rs72781680 0.846 rs72782114 chr2:24025740 G/A cg08917208 chr2:24149416 ATAD2B 0.96 8.71 0.47 3.37e-16 Lymphocyte counts; CESC cis rs11098499 0.562 rs13101722 chr4:120555975 C/A cg09307838 chr4:120376055 NA -0.61 -8.05 -0.44 2.8e-14 Corneal astigmatism; CESC cis rs7312774 0.618 rs4964501 chr12:107330079 C/T cg16260113 chr12:107380972 MTERFD3 -0.77 -6.99 -0.39 2.23e-11 Severe influenza A (H1N1) infection; CESC cis rs17376456 0.825 rs56108532 chr5:93276342 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 5.15 0.3 4.98e-7 Diabetic retinopathy; CESC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg13047869 chr3:10149882 C3orf24 0.39 5.05 0.3 8.22e-7 Alzheimer's disease; CESC cis rs6570726 0.846 rs9376954 chr6:145943737 T/A cg05347473 chr6:146136440 FBXO30 0.53 6.89 0.39 4.01e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg12386194 chr3:101231763 SENP7 0.46 5.61 0.33 5.16e-8 Colorectal cancer; CESC cis rs4900538 0.821 rs8016191 chr14:102825340 G/A cg18135206 chr14:102964638 TECPR2 -0.68 -8.13 -0.45 1.67e-14 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs10751667 0.666 rs10902235 chr11:938892 T/C cg01483505 chr11:975446 AP2A2 0.38 5.18 0.3 4.33e-7 Alzheimer's disease (late onset); CESC cis rs6540559 0.611 rs11810817 chr1:210011747 C/G cg21951975 chr1:209979733 IRF6 0.55 6.57 0.37 2.71e-10 Cleft lip with or without cleft palate; CESC cis rs6933660 0.720 rs6913515 chr6:151753470 G/C cg14262678 chr6:151773367 RMND1;C6orf211 0.65 9.33 0.5 4.4e-18 Menarche (age at onset); CESC cis rs4253772 0.591 rs6007795 chr22:46686792 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.76 8.8 0.48 1.8e-16 LDL cholesterol;Cholesterol, total; CESC cis rs9858542 0.953 rs11706370 chr3:49441091 G/A cg07274523 chr3:49395745 GPX1 0.66 8.22 0.45 8.84e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2455799 0.573 rs924753 chr3:15706124 C/T cg16303742 chr3:15540471 COLQ -0.35 -5.57 -0.32 6.24e-8 Mean platelet volume; CESC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg23281280 chr6:28129359 ZNF389 0.58 8.05 0.44 2.72e-14 Depression; CESC cis rs6584283 0.846 rs10883370 chr10:101291472 T/C cg09788492 chr10:101292477 NKX2-3 0.33 6.18 0.35 2.45e-9 Ulcerative colitis; CESC cis rs9399135 0.622 rs3817776 chr6:135256756 C/T cg12549451 chr6:135224345 NA -0.36 -5.43 -0.32 1.28e-7 Red blood cell count; CESC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg26314531 chr2:26401878 FAM59B -0.76 -8.42 -0.46 2.48e-15 Gut microbiome composition (summer); CESC cis rs854765 0.547 rs7212167 chr17:17913504 G/A cg09796270 chr17:17721594 SREBF1 0.4 5.52 0.32 7.97e-8 Total body bone mineral density; CESC cis rs2227631 0.505 rs4729662 chr7:100765559 C/T cg08053846 chr7:100769605 SERPINE1 -0.45 -5.26 -0.31 2.92e-7 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs10979 0.597 rs9390118 chr6:143907610 A/G cg25407410 chr6:143891975 LOC285740 -0.49 -6.31 -0.36 1.16e-9 Hypospadias; CESC cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg16339924 chr4:17578868 LAP3 0.64 7.91 0.44 6.79e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg04166393 chr7:2884313 GNA12 0.53 6.63 0.38 1.84e-10 Height; CESC cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 4.04e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 1.000 rs422780 chr6:167406209 A/G cg23791538 chr6:167370224 RNASET2 -0.59 -8.54 -0.46 1.09e-15 Crohn's disease; CESC cis rs12681288 0.862 rs2004701 chr8:1022287 A/G cg04851639 chr8:1020857 NA -0.38 -8.56 -0.47 9.08e-16 Schizophrenia; CESC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.32 0.54 3.32e-21 Prudent dietary pattern; CESC cis rs1728785 1.000 rs1182968 chr16:68573945 C/T cg02972257 chr16:68554789 NA -0.55 -6.32 -0.36 1.08e-9 Ulcerative colitis; CESC cis rs28647808 1.000 rs28709650 chr9:136276699 G/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs4253772 0.550 rs6008598 chr22:46704243 C/T cg00784671 chr22:46762841 CELSR1 -0.48 -5.55 -0.32 7.04e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9287719 0.901 rs6432109 chr2:10736821 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC trans rs208520 0.742 rs208454 chr6:66907783 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.84 -9.54 -0.51 9.64e-19 Exhaled nitric oxide output; CESC cis rs2439831 0.850 rs7169988 chr15:44060435 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.71 0.38 1.18e-10 Lung cancer in ever smokers; CESC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg02269571 chr22:50332266 NA -0.57 -6.99 -0.39 2.29e-11 Schizophrenia; CESC cis rs9287719 0.967 rs12995602 chr2:10753542 C/A cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs7116495 0.609 rs60054591 chr11:71825687 G/A cg26138937 chr11:71823887 C11orf51 1.22 7.75 0.43 2.02e-13 Severe influenza A (H1N1) infection; CESC cis rs7659604 0.502 rs4075066 chr4:122684283 T/C cg19671926 chr4:122722719 EXOSC9 0.6 7.65 0.43 3.84e-13 Type 2 diabetes; CESC cis rs881375 0.933 rs7028641 chr9:123691141 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.08 0.3 7.23e-7 Rheumatoid arthritis; CESC cis rs11676348 0.846 rs3890158 chr2:218990292 G/A cg00012203 chr2:219082015 ARPC2 -0.57 -7.46 -0.42 1.27e-12 Ulcerative colitis; CESC trans rs2727020 0.553 rs7479975 chr11:49581964 C/G cg15704280 chr7:45808275 SEPT13 -0.91 -15.17 -0.68 7.93e-38 Coronary artery disease; CESC cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg20701182 chr2:24300061 SF3B14 0.93 10.4 0.54 1.79e-21 Lymphocyte counts; CESC cis rs2952156 0.883 rs1495100 chr17:37832279 C/T cg07936489 chr17:37558343 FBXL20 -0.6 -7.57 -0.42 6.06e-13 Asthma; CESC cis rs2108622 0.711 rs113059233 chr19:15977368 G/A cg13772218 chr19:15982569 NA 0.29 5.71 0.33 2.98e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg11663144 chr21:46675770 NA -0.52 -7.66 -0.43 3.51e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6456156 0.846 rs7749827 chr6:167515624 C/T cg07741184 chr6:167504864 NA -0.35 -6.04 -0.35 5.2e-9 Primary biliary cholangitis; CESC cis rs6987853 0.736 rs6991995 chr8:42436219 A/C cg09913449 chr8:42400586 C8orf40 0.45 7.54 0.42 7.31e-13 Mean corpuscular hemoglobin concentration; CESC cis rs1499614 0.803 rs1922723 chr7:66175063 C/T cg13147721 chr7:65941812 NA -0.94 -8.9 -0.48 9.08e-17 Gout; CESC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9486719 0.843 rs2499797 chr6:96848669 C/T cg06623918 chr6:96969491 KIAA0776 0.79 7.21 0.4 6.01e-12 Migraine;Coronary artery disease; CESC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg08392591 chr16:89556376 ANKRD11 0.59 8.1 0.45 1.99e-14 Multiple myeloma (IgH translocation); CESC cis rs2235544 0.565 rs72664114 chr1:54471747 C/T cg25741118 chr1:54482237 LDLRAD1 -0.24 -5.76 -0.33 2.29e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs9487051 0.700 rs9400266 chr6:109596193 T/A cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg25405998 chr7:65216604 CCT6P1 0.44 5.07 0.3 7.49e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07503662 chr16:87761121 KLHDC4 0.47 6.14 0.35 3.02e-9 Fibrinogen levels; CESC cis rs11722228 0.522 rs7681250 chr4:10133013 G/T cg14348967 chr4:10160060 NA -0.39 -5.06 -0.3 7.9e-7 Gout;Urate levels;Serum uric acid levels; CESC cis rs4472734 0.965 rs61271474 chr1:214621877 G/A cg00063699 chr1:214624242 PTPN14 -0.33 -5.28 -0.31 2.76e-7 Height; CESC cis rs6964587 1.000 rs6961928 chr7:91669808 C/T cg17063962 chr7:91808500 NA 0.57 7.92 0.44 6.51e-14 Breast cancer; CESC cis rs1879734 0.731 rs7544346 chr1:54158475 C/T cg23596471 chr1:54105337 GLIS1 0.35 5.57 0.32 6.32e-8 Mitral valve prolapse; CESC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg09877947 chr5:131593287 PDLIM4 0.45 5.98 0.34 7.23e-9 Breast cancer; CESC cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs2637266 0.714 rs6480835 chr10:78446863 T/C cg18941641 chr10:78392320 NA 0.43 7.8 0.43 1.43e-13 Pulmonary function; CESC cis rs8070624 0.543 rs57728924 chr17:17875342 A/G cg16928487 chr17:17741425 SREBF1 -0.62 -10.37 -0.54 2.2e-21 Total body bone mineral density; CESC cis rs644799 1.000 rs557079 chr11:95530125 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.84 0.65 3.87e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs42714 0.688 rs73073997 chr7:28478668 G/A cg08140114 chr6:139482238 HECA -0.83 -6.02 -0.35 5.68e-9 Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals; CESC trans rs1493916 0.905 rs12455290 chr18:31398778 A/G cg27147174 chr7:100797783 AP1S1 -0.52 -6.93 -0.39 3.22e-11 Life satisfaction; CESC cis rs12477438 0.520 rs4340581 chr2:99725025 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.09 0.7 4.08e-41 Chronic sinus infection; CESC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg14393609 chr7:65229607 NA 0.48 6.24 0.36 1.74e-9 Aortic root size; CESC cis rs6495122 0.699 rs2168518 chr15:75081078 G/A cg14664628 chr15:75095509 CSK -0.68 -9.37 -0.5 3.23e-18 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC trans rs7246760 0.867 rs56377135 chr19:9820116 C/T cg02900749 chr2:68251473 NA -0.81 -7.26 -0.41 4.4e-12 Pursuit maintenance gain; CESC cis rs79387448 0.638 rs13405222 chr2:102981891 T/C cg09003973 chr2:102972529 NA 1.2 9.22 0.49 9.89e-18 Gut microbiota (bacterial taxa); CESC cis rs250677 0.522 rs4562031 chr5:148368451 A/G cg18129178 chr5:148520854 ABLIM3 0.45 5.04 0.3 8.58e-7 Breast cancer; CESC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg22903657 chr4:1355424 KIAA1530 -0.38 -5.23 -0.31 3.48e-7 Obesity-related traits; CESC cis rs501120 0.810 rs535176 chr10:44747059 C/T cg09554077 chr10:44749378 NA 0.52 6.92 0.39 3.41e-11 Coronary artery disease;Coronary heart disease; CESC cis rs12479064 0.724 rs2309618 chr2:99974473 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -7.2 -0.4 6.39e-12 Chronic sinus infection; CESC trans rs561341 1.000 rs4795670 chr17:30244839 T/C cg20587970 chr11:113659929 NA -0.89 -10.75 -0.55 1.33e-22 Hip circumference adjusted for BMI; CESC cis rs2635047 0.811 rs17723754 chr18:44771481 C/T cg24371990 chr18:44770781 NA 0.43 6.87 0.39 4.53e-11 Educational attainment; CESC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg07701084 chr6:150067640 NUP43 0.42 5.77 0.33 2.25e-8 Lung cancer; CESC cis rs854765 0.647 rs6826 chr17:18011140 C/T cg09796270 chr17:17721594 SREBF1 0.42 5.7 0.33 3.22e-8 Total body bone mineral density; CESC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg26354017 chr1:205819088 PM20D1 0.54 7.74 0.43 2.16e-13 Menarche (age at onset); CESC cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 11.25 0.57 2.87e-24 Hip circumference adjusted for BMI; CESC cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg21644426 chr2:191273491 MFSD6 -0.49 -6.69 -0.38 1.35e-10 Pulse pressure; CESC cis rs9815354 0.556 rs60966614 chr3:42005166 A/G cg03022575 chr3:42003672 ULK4 0.65 5.73 0.33 2.75e-8 Pulse pressure;Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21912093 chr14:73704842 PAPLN 0.59 7.09 0.4 1.24e-11 Gut microbiome composition (summer); CESC cis rs412050 0.696 rs79103791 chr22:22244897 A/G cg17089214 chr22:22089827 YPEL1 0.72 6.21 0.36 2.09e-9 Attention deficit hyperactivity disorder; CESC cis rs9467773 0.620 rs3800303 chr6:26598188 A/G cg20266910 chr6:26577678 NA 0.36 5.86 0.34 1.34e-8 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22496665 chr3:46887449 NA -0.43 -6.08 -0.35 4.21e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs5753618 0.583 rs2899164 chr22:31790289 G/A cg00478049 chr22:31556069 RNF185 -0.44 -5.19 -0.3 4.24e-7 Colorectal cancer; CESC cis rs3733585 0.699 rs62294331 chr4:9959889 A/G cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs12477438 0.520 rs11695751 chr2:99708247 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.18 0.68 6.85e-38 Chronic sinus infection; CESC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg11301795 chr4:187892539 NA -0.81 -14.49 -0.66 1.92e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg21963583 chr11:68658836 MRPL21 0.42 5.68 0.33 3.45e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs5758511 0.680 rs5751243 chr22:42617177 T/C cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.12 -0.3 5.79e-7 Birth weight; CESC cis rs9291683 0.546 rs12504565 chr4:10045145 G/A cg02734326 chr4:10020555 SLC2A9 0.45 6.19 0.36 2.29e-9 Bone mineral density; CESC cis rs8114671 0.647 rs1415771 chr20:33734493 G/A cg24642439 chr20:33292090 TP53INP2 0.51 6.5 0.37 3.86e-10 Height; CESC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg11644478 chr21:40555479 PSMG1 -1.01 -15.87 -0.7 2.52e-40 Cognitive function; CESC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.42 -5.59 -0.32 5.59e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg00431813 chr7:1051703 C7orf50 -0.39 -6.09 -0.35 3.97e-9 Longevity;Endometriosis; CESC cis rs830124 0.516 rs1177588 chr12:122389167 A/G cg22168489 chr12:122356033 WDR66 -0.38 -5.05 -0.3 8.27e-7 Urinary metabolites; CESC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg26587870 chr6:27730563 NA -0.55 -5.4 -0.31 1.47e-7 Depression; CESC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg05552183 chr6:42928497 GNMT 0.87 15.8 0.7 4.47e-40 Alzheimer's disease in APOE e4+ carriers; CESC cis rs6121246 0.697 rs6060446 chr20:30231637 T/C cg13852791 chr20:30311386 BCL2L1 0.8 8.21 0.45 9.79e-15 Mean corpuscular hemoglobin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07897837 chr1:231377046 C1orf131;GNPAT -0.58 -6.62 -0.38 1.95e-10 Gut microbiome composition (summer); CESC cis rs7107217 1.000 rs1873872 chr11:129473993 A/T cg24592846 chr11:129873229 NCRNA00167;PRDM10 0.42 5.36 0.31 1.84e-7 Breast cancer;Type 2 diabetes; CESC cis rs7216064 0.655 rs8078543 chr17:66037251 G/T cg07042672 chr17:66097459 LOC651250 0.66 8.74 0.47 2.69e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs12142240 0.698 rs17357711 chr1:46829013 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 3.02e-14 Menopause (age at onset); CESC cis rs950776 0.518 rs12594391 chr15:78816240 A/G cg06917634 chr15:78832804 PSMA4 0.79 11.88 0.59 2.16e-26 Sudden cardiac arrest; CESC cis rs1443512 0.812 rs1561987 chr12:54335268 C/T cg12374095 chr12:54320830 NA -0.42 -5.79 -0.34 1.96e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs2070488 0.695 rs6599201 chr3:38476614 A/G cg24069376 chr3:38537580 EXOG 0.33 5.5 0.32 9e-8 Electrocardiographic conduction measures; CESC trans rs1814175 0.754 rs28593359 chr11:50042357 C/T cg15704280 chr7:45808275 SEPT13 -1.05 -20.97 -0.79 3.22e-58 Height; CESC cis rs7937682 0.889 rs541198 chr11:111475340 A/G cg09085632 chr11:111637200 PPP2R1B -0.95 -14.72 -0.67 3.09e-36 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05137146 chr16:30103511 TBX6 0.55 6.37 0.36 8.36e-10 Gut microbiome composition (summer); CESC cis rs3768617 0.510 rs2296292 chr1:183086757 A/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.49e-35 Fuchs's corneal dystrophy; CESC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -6.38 -0.37 7.67e-10 Developmental language disorder (linguistic errors); CESC trans rs853679 0.766 rs9368561 chr6:28168343 C/T cg06606381 chr12:133084897 FBRSL1 -0.64 -6.06 -0.35 4.68e-9 Depression; CESC cis rs644799 0.544 rs687559 chr11:95598629 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.45 -5.86 -0.34 1.36e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9488822 0.676 rs873879 chr6:116391259 A/G cg15226275 chr6:116381976 FRK 0.26 6.69 0.38 1.3e-10 Cholesterol, total;LDL cholesterol; CESC cis rs1355223 0.506 rs7130774 chr11:34869267 A/G cg11622362 chr11:34938112 PDHX;APIP 0.46 5.45 0.32 1.14e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07161888 chr16:53537348 AKTIP -0.45 -6.13 -0.35 3.19e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7631605 0.905 rs12629462 chr3:37226969 A/C cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.24 -0.31 3.21e-7 Cerebrospinal P-tau181p levels; CESC cis rs9858542 0.953 rs11713474 chr3:49611457 A/G cg03060546 chr3:49711283 APEH -0.53 -6.17 -0.35 2.52e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9300255 0.739 rs4759417 chr12:123746510 C/T cg19016782 chr12:123741754 C12orf65 -0.5 -7.23 -0.41 5.16e-12 Neutrophil percentage of white cells; CESC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.63 -0.33 4.6e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs11723261 0.546 rs57839456 chr4:148289 C/G cg12746427 chr4:53362 ZNF718;ZNF595 0.46 5.96 0.34 8.05e-9 Immune response to smallpox vaccine (IL-6); CESC cis rs6963495 0.872 rs1569134 chr7:105158228 T/C cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs3092073 0.624 rs7275164 chr20:44604822 G/A cg23303369 chr20:44641161 MMP9 0.33 5.14 0.3 5.29e-7 Intelligence (multi-trait analysis); CESC cis rs2050392 0.590 rs2065723 chr10:30720462 A/T cg18806716 chr10:30721971 MAP3K8 -0.63 -9.25 -0.49 7.67e-18 Inflammatory bowel disease; CESC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15399923 chr2:209130889 PIKFYVE 0.6 6.13 0.35 3.13e-9 Bipolar disorder and schizophrenia; CESC cis rs4523957 0.818 rs4790887 chr17:2130592 C/A cg16513277 chr17:2031491 SMG6 0.63 8.77 0.47 2.19e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4253772 0.591 rs6008546 chr22:46686377 T/G cg09491104 chr22:46646882 C22orf40 -0.56 -7.09 -0.4 1.24e-11 LDL cholesterol;Cholesterol, total; CESC cis rs13191362 0.507 rs2849511 chr6:163139050 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.63 -7.46 -0.42 1.24e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4919044 0.756 rs2486686 chr10:94778511 G/T cg00487187 chr10:94451625 HHEX -0.45 -5.05 -0.3 8.21e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11468462 chr12:57610686 NXPH4 0.53 6.05 0.35 5e-9 Gut microbiome composition (summer); CESC cis rs2073300 0.609 rs6137938 chr20:23389127 C/G cg12062639 chr20:23401060 NAPB 0.99 8.13 0.45 1.62e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7772486 0.846 rs9403767 chr6:146402386 G/T cg05347473 chr6:146136440 FBXO30 0.5 6.37 0.36 8.55e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg16339924 chr4:17578868 LAP3 0.66 8.42 0.46 2.35e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1577917 1.000 rs10455158 chr6:86672825 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.92 -0.34 9.76e-9 Response to antipsychotic treatment; CESC cis rs12142240 0.698 rs13374893 chr1:46843800 A/G cg00530320 chr1:46809349 NSUN4 0.59 7.97 0.44 4.81e-14 Menopause (age at onset); CESC cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.03 0.3 8.96e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6933660 0.536 rs3800274 chr6:151759192 T/G cg02564969 chr6:151773285 C6orf211;RMND1 0.51 6.09 0.35 3.98e-9 Menarche (age at onset); CESC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.51 5.61 0.33 5.08e-8 Schizophrenia; CESC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg23758822 chr17:41437982 NA 1.02 15.6 0.69 2.35e-39 Menopause (age at onset); CESC cis rs2204008 0.591 rs11495396 chr12:38380182 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.23 0.36 1.87e-9 Bladder cancer; CESC cis rs11750568 0.933 rs7719616 chr5:178536584 A/G cg10208897 chr5:178548229 ADAMTS2 0.38 5.32 0.31 2.2e-7 Height; CESC cis rs36051895 0.658 rs10974910 chr9:5010091 G/A cg02405213 chr9:5042618 JAK2 -0.48 -5.53 -0.32 7.83e-8 Pediatric autoimmune diseases; CESC trans rs11098499 0.954 rs59866101 chr4:120296591 T/G cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg03538708 chr1:25844672 NA -0.38 -5.63 -0.33 4.66e-8 Erythrocyte sedimentation rate; CESC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg26354017 chr1:205819088 PM20D1 0.39 5.21 0.3 3.76e-7 Prostate-specific antigen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13846960 chr9:2718456 KCNV2 0.48 6.25 0.36 1.6e-9 Fibrinogen levels; CESC cis rs916888 0.773 rs1378358 chr17:44787312 C/T cg27589368 chr17:43923255 LOC100128977;IMP5 -0.39 -5.24 -0.31 3.28e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs910316 0.967 rs4899550 chr14:75647666 C/T cg08847533 chr14:75593920 NEK9 -0.94 -16.62 -0.71 5.67e-43 Height; CESC cis rs10927875 0.632 rs2862162 chr1:16142960 A/C cg04889800 chr1:16163555 FLJ37453 -0.37 -5.2 -0.3 4.08e-7 Dilated cardiomyopathy; CESC cis rs7605827 0.930 rs6749063 chr2:15565278 T/G cg19274914 chr2:15703543 NA 0.35 6.29 0.36 1.3e-9 Educational attainment (years of education); CESC cis rs344364 0.511 rs2982447 chr16:1947413 C/T cg03013636 chr16:1946785 NA -0.49 -6.61 -0.38 2.09e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs11920090 0.720 rs58284370 chr3:170738849 G/A cg09710316 chr3:170744871 SLC2A2 0.56 6.31 0.36 1.17e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg00033643 chr7:134001901 SLC35B4 0.44 5.76 0.33 2.33e-8 Mean platelet volume; CESC cis rs4253772 0.872 rs41362646 chr22:46633505 G/A cg18190219 chr22:46762943 CELSR1 -0.61 -5.86 -0.34 1.39e-8 LDL cholesterol;Cholesterol, total; CESC cis rs807669 0.548 rs885979 chr22:19198375 T/C cg02655711 chr22:19163373 SLC25A1 0.79 11.96 0.59 1.24e-26 Metabolite levels; CESC cis rs2249694 0.960 rs4133041 chr10:135408387 G/A cg20169779 chr10:135381914 SYCE1 -0.39 -5.52 -0.32 7.97e-8 Obesity-related traits; CESC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg25036284 chr2:26402008 FAM59B 0.85 8.95 0.48 6.29e-17 Gut microbiome composition (summer); CESC cis rs55692411 0.517 rs62262106 chr3:49991427 A/G cg24308560 chr3:49941425 MST1R -0.53 -6.39 -0.37 7.37e-10 Intelligence (multi-trait analysis); CESC cis rs12912251 1.000 rs7163869 chr15:38988391 G/C cg01338139 chr15:38987640 C15orf53 -0.47 -5.43 -0.32 1.26e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg22800045 chr5:56110881 MAP3K1 0.81 9.67 0.51 3.84e-19 Initial pursuit acceleration; CESC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.17e-9 Menopause (age at onset); CESC cis rs863345 0.604 rs6670343 chr1:158497258 A/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.78e-11 Pneumococcal bacteremia; CESC cis rs4835473 0.897 rs7681914 chr4:144629991 A/G cg25736465 chr4:144833511 NA 0.4 6.17 0.35 2.59e-9 Immature fraction of reticulocytes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06925625 chr13:113887609 CUL4A 0.55 7.18 0.4 7.24e-12 Fibrinogen levels; CESC cis rs7831492 0.564 rs11787479 chr8:41613496 A/G cg17182837 chr8:41585554 ANK1 -0.41 -6.25 -0.36 1.65e-9 Colorectal cancer; CESC cis rs6460942 0.597 rs6944517 chr7:12515283 C/T cg06484146 chr7:12443880 VWDE -0.64 -7.13 -0.4 9.4e-12 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20877507 chr13:50464614 LOC220429 0.43 6.12 0.35 3.41e-9 Fibrinogen levels; CESC cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg14784868 chr12:69753453 YEATS4 0.83 12.94 0.62 5.29e-30 Blood protein levels; CESC cis rs17826219 0.500 rs28452421 chr17:29083980 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Body mass index; CESC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg18758796 chr5:131593413 PDLIM4 0.41 5.41 0.32 1.43e-7 Breast cancer; CESC cis rs739401 0.572 rs410820 chr11:3080102 G/A cg25174290 chr11:3078921 CARS 0.63 8.57 0.47 8.78e-16 Longevity; CESC cis rs3126085 0.935 rs7531094 chr1:152176850 A/G cg26876637 chr1:152193138 HRNR 0.46 5.33 0.31 2.14e-7 Atopic dermatitis; CESC cis rs2066819 1.000 rs111885088 chr12:56657216 A/C cg26734620 chr12:56694298 CS 1.03 6.76 0.38 8.6e-11 Psoriasis vulgaris; CESC cis rs2637266 1.000 rs7897015 chr10:78366566 G/C cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg22442454 chr1:209979470 IRF6 0.43 5.15 0.3 5.13e-7 Cleft lip with or without cleft palate; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10685559 chr22:18633123 USP18 -0.43 -6.01 -0.35 6.05e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg10691866 chr7:65817282 TPST1 0.33 5.51 0.32 8.51e-8 Aortic root size; CESC cis rs6500395 0.890 rs3843724 chr16:48618573 C/G cg04672837 chr16:48644449 N4BP1 0.47 5.82 0.34 1.72e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4969178 0.965 rs3817294 chr17:76396963 A/G cg20026190 chr17:76395443 PGS1 0.49 7.81 0.43 1.34e-13 HDL cholesterol levels; CESC cis rs6061231 0.761 rs2427312 chr20:60970591 C/T cg22601191 chr20:60968625 CABLES2 0.58 5.61 0.33 5.15e-8 Colorectal cancer; CESC cis rs10927875 0.632 rs4661666 chr1:16162471 C/A cg21385522 chr1:16154831 NA -1.02 -17.0 -0.72 2.47e-44 Dilated cardiomyopathy; CESC cis rs3820068 0.603 rs59558854 chr1:15971399 T/G cg18133145 chr1:16060689 PLEKHM2 -0.39 -5.04 -0.3 8.81e-7 Systolic blood pressure; CESC cis rs12541635 0.934 rs62527361 chr8:107021574 T/A cg10147462 chr8:107024639 NA 0.4 5.65 0.33 4.1e-8 Age of smoking initiation; CESC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.55 -7.31 -0.41 3.22e-12 Menarche (age at onset); CESC cis rs2011503 1.000 rs55927782 chr19:19642032 T/C cg11584989 chr19:19387371 SF4 0.63 7.15 0.4 8.47e-12 Bipolar disorder; CESC cis rs72781680 0.848 rs6754694 chr2:24155448 T/C cg20701182 chr2:24300061 SF3B14 0.65 5.77 0.33 2.22e-8 Lymphocyte counts; CESC cis rs17376456 1.000 rs13185608 chr5:93509688 T/G cg25358565 chr5:93447407 FAM172A 1.17 10.96 0.56 2.63e-23 Diabetic retinopathy; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15472170 chr1:12012720 PLOD1 -0.44 -6.11 -0.35 3.51e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00564598 chr19:10216860 SNORD105;PPAN-P2RY11;PPAN 0.66 7.73 0.43 2.21e-13 Gut microbiome composition (summer); CESC cis rs3796352 0.892 rs11718388 chr3:53076415 G/A cg12962167 chr3:53033115 SFMBT1 0.61 5.04 0.3 8.66e-7 Immune reponse to smallpox (secreted IL-2); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13155599 chr4:120221765 C4orf3 -0.49 -6.38 -0.36 7.83e-10 Fibrinogen levels; CESC cis rs11190604 1.000 rs11190558 chr10:102209397 C/A cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.41 5.81 0.34 1.83e-8 Schizophrenia; CESC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg18032046 chr6:28092343 ZSCAN16 0.55 6.22 0.36 1.92e-9 Depression; CESC cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg03467027 chr4:99064603 C4orf37 0.48 5.95 0.34 8.67e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2737618 0.674 rs2737683 chr1:200092448 G/A cg21825944 chr1:200113062 NR5A2 -0.45 -6.72 -0.38 1.08e-10 Uric acid levels; CESC cis rs295140 0.605 rs10931893 chr2:201114652 A/G cg23649088 chr2:200775458 C2orf69 -0.42 -5.71 -0.33 3.02e-8 QT interval; CESC cis rs2011503 1.000 rs77616520 chr19:19652776 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC cis rs763121 0.752 rs6001190 chr22:39073811 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.61 0.47 6.51e-16 Menopause (age at onset); CESC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg13206674 chr6:150067644 NUP43 0.45 6.72 0.38 1.12e-10 Lung cancer; CESC cis rs61931739 0.500 rs7307583 chr12:34521711 T/C cg06521331 chr12:34319734 NA -0.37 -5.09 -0.3 6.85e-7 Morning vs. evening chronotype; CESC cis rs3015497 0.586 rs12587842 chr14:51092562 A/G cg09863266 chr14:51125203 SAV1 -0.32 -5.07 -0.3 7.62e-7 Mean platelet volume; CESC cis rs8067545 0.532 rs12936794 chr17:19912570 C/T cg12073167 chr17:19770448 ULK2 -0.48 -5.39 -0.31 1.54e-7 Schizophrenia; CESC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.67 0.64 1.52e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3741489 1.000 rs4758915 chr12:133477147 A/G cg01499426 chr12:133417423 CHFR 0.89 5.57 0.32 6.38e-8 Cognitive function; CESC cis rs11608355 0.508 rs11066394 chr12:109799212 C/A cg19025524 chr12:109796872 NA -0.42 -5.28 -0.31 2.63e-7 Neuroticism; CESC trans rs4671386 0.747 rs907573 chr2:60523559 C/T cg24386296 chr4:1723849 TMEM129;TACC3 -0.48 -6.07 -0.35 4.5e-9 Acne (severe); CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg24451074 chr3:129035583 H1FX;C3orf47 0.47 6.17 0.35 2.61e-9 Weight; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg20591167 chr15:99602178 NA -0.49 -7.48 -0.42 1.09e-12 Vertical cup-disc ratio; CESC cis rs897984 0.645 rs58726213 chr16:31044683 A/G cg00531865 chr16:30841666 NA -0.39 -5.49 -0.32 9.18e-8 Dementia with Lewy bodies; CESC cis rs708547 0.647 rs1718839 chr4:57827206 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.6 7.98 0.44 4.41e-14 Response to bleomycin (chromatid breaks); CESC cis rs78456975 0.550 rs10197874 chr2:1545310 A/G cg01028140 chr2:1542097 TPO -0.5 -6.27 -0.36 1.45e-9 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg17971929 chr21:40555470 PSMG1 1.06 16.27 0.71 9.3e-42 Cognitive function; CESC cis rs35955747 0.869 rs131213 chr22:31753849 C/T cg25791279 chr22:32026902 PISD 0.49 6.07 0.35 4.51e-9 Neutrophil count;Sum basophil neutrophil counts; CESC trans rs11039798 0.588 rs7479642 chr11:48553808 G/T cg15704280 chr7:45808275 SEPT13 0.66 6.62 0.38 1.97e-10 Axial length; CESC cis rs1858740 0.509 rs196375 chr3:38422919 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.63 8.7 0.47 3.53e-16 Schizophrenia; CESC cis rs7107174 1.000 rs9651768 chr11:77996020 C/T cg02023728 chr11:77925099 USP35 0.38 5.6 0.33 5.35e-8 Testicular germ cell tumor; CESC cis rs7851660 0.527 rs7870540 chr9:100573925 T/C cg13688889 chr9:100608707 NA -0.9 -14.95 -0.68 4.69e-37 Strep throat; CESC cis rs863345 0.967 rs1592256 chr1:158470596 C/T cg12129480 chr1:158549410 OR10X1 -0.31 -6.19 -0.36 2.34e-9 Pneumococcal bacteremia; CESC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.52 0.37 3.63e-10 Prudent dietary pattern; CESC cis rs9858542 0.953 rs1873625 chr3:49666964 C/A cg03060546 chr3:49711283 APEH -0.56 -6.6 -0.38 2.23e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs460214 0.576 rs28446127 chr21:40029568 C/A cg05519781 chr21:40033154 ERG -0.45 -5.46 -0.32 1.09e-7 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs6831352 0.918 rs29001199 chr4:100053891 A/G cg12011299 chr4:100065546 ADH4 -0.61 -6.62 -0.38 1.94e-10 Alcohol dependence; CESC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.62 8.03 0.44 3.18e-14 Menopause (age at onset); CESC cis rs10927875 0.864 rs1976402 chr1:16143779 G/A cg21385522 chr1:16154831 NA -0.93 -11.77 -0.59 5.17e-26 Dilated cardiomyopathy; CESC cis rs3956705 0.762 rs13311608 chr7:32999601 C/T cg06627557 chr7:32535165 LSM5;AVL9 -0.47 -5.64 -0.33 4.31e-8 Red cell distribution width; CESC cis rs7084402 0.967 rs1620404 chr10:60327830 G/A cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs854765 0.583 rs4244602 chr17:17841456 A/G cg09796270 chr17:17721594 SREBF1 0.46 6.41 0.37 6.66e-10 Total body bone mineral density; CESC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg14820908 chr5:178986412 RUFY1 0.44 6.42 0.37 6.11e-10 Lung cancer; CESC trans rs2623325 0.874 rs73138305 chr3:99139531 G/A cg19595760 chr1:25948511 MAN1C1 -0.48 -6.28 -0.36 1.4e-9 Optic cup area;Vertical cup-disc ratio; CESC cis rs4889855 0.614 rs9892081 chr17:78484484 A/C cg16591659 chr17:78472290 NA 0.45 6.83 0.39 5.65e-11 Fractional excretion of uric acid; CESC cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg26874164 chr19:58962979 ZNF324B 0.58 7.92 0.44 6.46e-14 Uric acid clearance; CESC cis rs9527 0.571 rs12219246 chr10:104613355 A/G cg04362960 chr10:104952993 NT5C2 0.47 6.0 0.35 6.31e-9 Arsenic metabolism; CESC cis rs9457247 1.000 rs389956 chr6:167407254 T/G cg25258033 chr6:167368657 RNASET2 0.39 5.89 0.34 1.15e-8 Crohn's disease; CESC cis rs7917772 0.502 rs10748827 chr10:104368336 G/T cg22532475 chr10:104410764 TRIM8 -0.38 -6.52 -0.37 3.55e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18652453 chr5:68665041 TAF9;RAD17 -0.44 -6.2 -0.36 2.19e-9 Gambling; CESC cis rs858239 0.600 rs10256359 chr7:23123877 C/T cg23682824 chr7:23144976 KLHL7 0.54 7.58 0.42 5.85e-13 Cerebrospinal fluid biomarker levels; CESC cis rs938554 0.501 rs7671266 chr4:10056376 C/T cg02734326 chr4:10020555 SLC2A9 -0.45 -5.07 -0.3 7.62e-7 Blood metabolite levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01471259 chr16:2645846 PDPK1 -0.5 -6.74 -0.38 1.01e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2180341 0.960 rs9398839 chr6:127665863 G/A cg27446573 chr6:127587934 RNF146 1.08 15.6 0.69 2.29e-39 Breast cancer; CESC trans rs561341 0.941 rs2428341 chr17:30317295 C/T cg20587970 chr11:113659929 NA -0.84 -10.91 -0.56 3.98e-23 Hip circumference adjusted for BMI; CESC cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg05347473 chr6:146136440 FBXO30 -0.71 -8.51 -0.46 1.29e-15 Lobe attachment (rater-scored or self-reported); CESC cis rs992157 0.661 rs10171839 chr2:219051314 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.65 9.47 0.5 1.68e-18 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23298564 chr19:41256395 C19orf54;SNRPA -0.55 -6.47 -0.37 4.7e-10 Gut microbiome composition (summer); CESC cis rs117623576 0.680 rs740859 chr10:32361839 G/A cg03047570 chr10:32398778 NA -0.64 -6.36 -0.36 9.02e-10 Anti-saccade response; CESC cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.47e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26289049 chr3:134080517 AMOTL2 -0.54 -6.38 -0.36 7.7e-10 Gut microbiome composition (summer); CESC cis rs73206853 0.563 rs7301769 chr12:111171026 T/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.7 0.33 3.23e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs763121 0.853 rs2294296 chr22:39053049 T/C cg06022373 chr22:39101656 GTPBP1 0.88 13.87 0.65 3.04e-33 Menopause (age at onset); CESC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs7223438 chr17:37521355 T/C cg15445000 chr17:37608096 MED1 -0.41 -6.54 -0.37 3.23e-10 Glomerular filtration rate (creatinine); CESC cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg24110177 chr3:50126178 RBM5 0.54 7.47 0.42 1.17e-12 Body mass index; CESC cis rs7940866 0.774 rs10894292 chr11:130820757 C/T cg12179176 chr11:130786555 SNX19 0.6 8.12 0.45 1.79e-14 Schizophrenia; CESC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg17971929 chr21:40555470 PSMG1 -0.55 -6.94 -0.39 3.03e-11 Menarche (age at onset); CESC cis rs9596863 0.861 rs4088520 chr13:54441906 C/T ch.13.53330881F chr13:54432880 NA -0.59 -5.18 -0.3 4.3e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs7605827 0.897 rs6431698 chr2:15540156 G/C cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.45e-9 Educational attainment (years of education); CESC cis rs863345 0.933 rs10797015 chr1:158468265 T/G cg12129480 chr1:158549410 OR10X1 -0.31 -6.23 -0.36 1.78e-9 Pneumococcal bacteremia; CESC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg15369054 chr17:80825471 TBCD 0.53 7.17 0.4 7.36e-12 Breast cancer; CESC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg18404041 chr3:52824283 ITIH1 -0.4 -6.71 -0.38 1.19e-10 Bipolar disorder; CESC cis rs6665290 0.566 rs1513617 chr1:227447213 C/T cg10327440 chr1:227177885 CDC42BPA 0.89 12.42 0.61 3.28e-28 Myeloid white cell count; CESC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg21782813 chr7:2030301 MAD1L1 -0.52 -7.44 -0.42 1.43e-12 Bipolar disorder and schizophrenia; CESC cis rs9435341 0.930 rs61798463 chr1:107565934 G/A cg09367891 chr1:107599246 PRMT6 0.71 8.35 0.46 3.94e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg10691866 chr7:65817282 TPST1 0.3 5.05 0.3 8.38e-7 Aortic root size; CESC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 11.97 0.59 1.14e-26 Alzheimer's disease; CESC cis rs11792861 0.926 rs59904140 chr9:111910051 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 5.24 0.31 3.36e-7 Menarche (age at onset); CESC cis rs3806843 0.735 rs2563314 chr5:140047289 A/G cg26395211 chr5:140044315 WDR55 0.47 6.03 0.35 5.51e-9 Depressive symptoms (multi-trait analysis); CESC cis rs7267979 1.000 rs6037105 chr20:25374199 C/A cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.85e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7223966 0.961 rs17631394 chr17:61646000 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.47 -5.22 -0.31 3.65e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7945705 0.967 rs1569408 chr11:8909732 G/A cg12365402 chr11:9010492 NRIP3 0.38 5.81 0.34 1.78e-8 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07192240 chr11:3829780 PGAP2 0.53 6.22 0.36 1.91e-9 Gut microbiome composition (summer); CESC cis rs4699052 0.625 rs2138592 chr4:104255718 A/G cg16532752 chr4:104119610 CENPE -0.39 -5.52 -0.32 8.23e-8 Testicular germ cell tumor; CESC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg19592336 chr6:28129416 ZNF389 -0.5 -6.51 -0.37 3.74e-10 Depression; CESC cis rs2832191 0.791 rs2832202 chr21:30501342 G/A cg08807101 chr21:30365312 RNF160 -0.73 -10.05 -0.53 2.35e-20 Dental caries; CESC cis rs6121246 0.542 rs2376990 chr20:30238744 G/A cg13852791 chr20:30311386 BCL2L1 0.77 7.96 0.44 5e-14 Mean corpuscular hemoglobin; CESC cis rs6493487 0.546 rs12904155 chr15:51356728 C/T cg02338191 chr15:51200825 AP4E1 -0.56 -5.39 -0.31 1.59e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9303280 0.837 rs907092 chr17:37922259 A/G cg19468946 chr17:37922297 IKZF3 0.47 6.5 0.37 4.01e-10 Self-reported allergy; CESC cis rs13082711 0.519 rs13091109 chr3:27229125 G/A cg02860705 chr3:27208620 NA 0.59 7.39 0.41 1.89e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs1941023 0.606 rs7946122 chr11:60172770 G/A cg08716584 chr11:60157161 MS4A7 -0.55 -9.03 -0.48 3.7e-17 Congenital heart disease (maternal effect); CESC cis rs10779751 0.734 rs2039840 chr1:11125866 G/A cg08854313 chr1:11322531 MTOR 0.77 10.41 0.54 1.73e-21 Body mass index; CESC cis rs2742234 0.541 rs4648313 chr10:43716739 G/A cg15436174 chr10:43711423 RASGEF1A 0.47 5.58 0.32 5.81e-8 Hirschsprung disease; CESC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg03188948 chr7:1209495 NA 0.66 6.79 0.38 7.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11871801 0.958 rs8081779 chr17:40571395 G/A cg21433558 chr17:40837037 CNTNAP1 0.45 5.04 0.3 8.46e-7 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09315918 chr1:206137767 FAM72A 0.57 6.3 0.36 1.23e-9 Gut microbiome composition (summer); CESC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg17724175 chr1:150552817 MCL1 -0.5 -7.92 -0.44 6.36e-14 Blood protein levels; CESC trans rs11098499 0.779 rs28495013 chr4:120375831 A/C cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg25036284 chr2:26402008 FAM59B -0.86 -9.4 -0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg13770153 chr20:60521292 NA -0.46 -6.05 -0.35 4.84e-9 Body mass index; CESC cis rs703842 0.616 rs870392 chr12:58219173 C/A cg02175503 chr12:58329896 NA 0.48 5.88 0.34 1.25e-8 Multiple sclerosis; CESC cis rs2228479 0.850 rs62056061 chr16:89901767 G/A cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs9788682 1.000 rs2036534 chr15:78826948 T/C cg06917634 chr15:78832804 PSMA4 -0.56 -6.69 -0.38 1.3100000000000001e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs9287719 0.967 rs6712304 chr2:10754375 A/C cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs769267 0.792 rs4808961 chr19:19577215 C/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.44 5.51 0.32 8.47e-8 Tonsillectomy; CESC cis rs4820294 1.000 rs7291867 chr22:38062112 C/G cg21798802 chr22:38057573 PDXP 0.47 8.12 0.45 1.81e-14 Fat distribution (HIV); CESC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.64 0.47 5.23e-16 Menopause (age at onset); CESC trans rs9858542 0.953 rs6803222 chr3:49665976 T/G cg21659725 chr3:3221576 CRBN -0.52 -6.32 -0.36 1.13e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs28647808 0.867 rs28534766 chr9:136273381 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs34779708 0.931 rs1926554 chr10:35344969 C/T cg03585969 chr10:35415529 CREM 0.75 9.67 0.51 3.92e-19 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26663063 chr12:49239477 DDX23 -0.56 -6.3 -0.36 1.23e-9 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.24e-9 Extrinsic epigenetic age acceleration; CESC cis rs116095464 0.558 rs7736600 chr5:231337 A/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.22 0.31 3.68e-7 Breast cancer; CESC cis rs9788682 0.748 rs2456020 chr15:78868398 C/T cg24631222 chr15:78858424 CHRNA5 0.78 9.72 0.51 2.6e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg23985595 chr17:80112537 CCDC57 -0.4 -6.32 -0.36 1.12e-9 Life satisfaction; CESC cis rs6456156 0.586 rs7746628 chr6:167483235 A/G cg07741184 chr6:167504864 NA 0.37 6.36 0.36 8.83e-10 Primary biliary cholangitis; CESC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg06481639 chr22:41940642 POLR3H 0.6 5.98 0.34 7.25e-9 Vitiligo; CESC cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg15017067 chr4:17643749 FAM184B 0.38 5.41 0.32 1.41e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11719291 0.833 rs11715835 chr3:48770732 C/T cg00383909 chr3:49044727 WDR6 0.87 6.49 0.37 4.18e-10 Cognitive function; CESC cis rs847577 0.748 rs13221897 chr7:97719699 G/A cg24562669 chr7:97807699 LMTK2 0.63 10.23 0.53 6.29e-21 Breast cancer; CESC cis rs4594175 0.926 rs11157804 chr14:51630340 A/G cg23942311 chr14:51606299 NA -0.35 -5.48 -0.32 9.86e-8 Cancer; CESC cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg11752832 chr7:134001865 SLC35B4 0.53 6.88 0.39 4.35e-11 Mean platelet volume; CESC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg05863683 chr7:1912471 MAD1L1 -0.43 -6.36 -0.36 8.96e-10 Bipolar disorder and schizophrenia; CESC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg00166722 chr3:10149974 C3orf24 0.48 5.92 0.34 1.01e-8 Alzheimer's disease; CESC cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg16339924 chr4:17578868 LAP3 0.64 7.91 0.44 6.79e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg06636001 chr8:8085503 FLJ10661 0.53 6.78 0.38 7.72e-11 Mood instability; CESC cis rs854765 0.547 rs2955353 chr17:17948979 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.33 -0.36 1.03e-9 Total body bone mineral density; CESC cis rs9549260 0.564 rs4943808 chr13:41293950 C/T cg21288729 chr13:41239152 FOXO1 0.59 7.61 0.42 4.7e-13 Red blood cell count; CESC cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.6e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg06766960 chr11:133703094 NA -0.37 -5.19 -0.3 4.25e-7 Childhood ear infection; CESC cis rs9611565 0.592 rs12484254 chr22:41962003 T/A cg03806693 chr22:41940476 POLR3H -0.97 -12.07 -0.6 4.96e-27 Vitiligo; CESC cis rs6426558 0.537 rs6685823 chr1:227270835 A/G cg10327440 chr1:227177885 CDC42BPA 0.47 5.79 0.34 1.96e-8 Neutrophil percentage of white cells; CESC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.53 0.81 1.67e-63 Prudent dietary pattern; CESC cis rs9911578 0.967 rs686425 chr17:56776730 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.17 0.3 4.67e-7 Intelligence (multi-trait analysis); CESC trans rs853679 0.546 rs200954 chr6:27838764 C/G cg06606381 chr12:133084897 FBRSL1 -0.78 -7.49 -0.42 1.05e-12 Depression; CESC cis rs4253772 0.591 rs6007726 chr22:46650858 A/C cg24881330 chr22:46731750 TRMU 0.89 10.09 0.53 1.86e-20 LDL cholesterol;Cholesterol, total; CESC cis rs12042107 1.000 rs10922907 chr1:91193049 A/T cg13456504 chr1:91191583 NA 0.37 6.66 0.38 1.53e-10 Educational attainment; CESC cis rs9457247 1.000 rs397713 chr6:167386714 G/A cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs3806843 0.966 rs12659129 chr5:140147248 T/C cg26395211 chr5:140044315 WDR55 -0.39 -5.12 -0.3 5.97e-7 Depressive symptoms (multi-trait analysis); CESC cis rs12765878 1.000 rs10883942 chr10:105651386 A/G cg11005552 chr10:105648138 OBFC1 0.36 5.4 0.31 1.52e-7 Coronary artery disease; CESC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg05457628 chr5:178986728 RUFY1 0.57 8.81 0.48 1.7e-16 Lung cancer; CESC cis rs2625529 0.618 rs6494992 chr15:72420750 G/C cg16672083 chr15:72433130 SENP8 0.42 6.38 0.36 7.92e-10 Red blood cell count; CESC cis rs34390795 1 rs34390795 chr12:133112394 CGT/C cg06183872 chr12:133049993 NA 0.5 5.85 0.34 1.47e-8 Red blood cell count; CESC cis rs4948102 0.655 rs4947533 chr7:56071282 T/C cg09872392 chr7:56161020 PHKG1 -0.44 -6.73 -0.38 1.02e-10 Plasma homocysteine levels (post-methionine load test); CESC cis rs2997447 0.761 rs79778025 chr1:26449337 A/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.58 5.08 0.3 7.24e-7 QRS complex (12-leadsum); CESC cis rs8005677 1.000 rs10148215 chr14:23382345 C/T cg01529538 chr14:23388837 RBM23 0.51 6.89 0.39 4.01e-11 Cognitive ability (multi-trait analysis); CESC cis rs3091242 0.933 rs9438904 chr1:25756860 T/C cg12412775 chr1:25698385 RHCE -0.28 -5.07 -0.3 7.51e-7 Erythrocyte sedimentation rate; CESC cis rs6032067 0.777 rs56191952 chr20:43802487 A/G cg11264863 chr20:43835661 SEMG1 0.5 5.38 0.31 1.62e-7 Blood protein levels; CESC cis rs7666738 0.515 rs28615369 chr4:98896858 C/T cg17366294 chr4:99064904 C4orf37 0.51 6.53 0.37 3.27e-10 Colonoscopy-negative controls vs population controls; CESC cis rs7772486 0.714 rs1883365 chr6:146076749 C/T cg23711669 chr6:146136114 FBXO30 -0.88 -13.21 -0.63 5.93e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs1008375 0.797 rs6843530 chr4:17593605 G/T cg27347728 chr4:17578864 LAP3 0.43 5.3 0.31 2.49e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg15441629 chr19:16582551 EPS15L1 0.49 6.43 0.37 6.06e-10 Myopia (pathological); CESC cis rs9911578 1.000 rs3744108 chr17:56585872 G/C cg10487724 chr17:56770010 TEX14;RAD51C -0.38 -5.04 -0.3 8.8e-7 Intelligence (multi-trait analysis); CESC cis rs921968 0.541 rs523305 chr2:219402691 T/C cg02176678 chr2:219576539 TTLL4 0.5 9.0 0.48 4.36e-17 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03227570 chr1:17766306 RCC2 0.56 6.34 0.36 9.76e-10 Gut microbiome composition (summer); CESC cis rs7264396 0.563 rs2425121 chr20:34326186 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.88e-22 Total cholesterol levels; CESC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.36 -0.31 1.8e-7 Developmental language disorder (linguistic errors); CESC cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg17775713 chr3:133465469 TF 0.35 6.22 0.36 1.88e-9 Iron status biomarkers (transferrin levels); CESC cis rs453301 0.653 rs7853 chr8:8890814 A/G cg15556689 chr8:8085844 FLJ10661 0.5 6.18 0.35 2.4e-9 Joint mobility (Beighton score); CESC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.58 -0.37 2.45e-10 Bipolar disorder; CESC cis rs6141600 0.760 rs2746097 chr20:34672923 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.41 5.39 0.31 1.58e-7 Height;Hip circumference; CESC trans rs60380162 0.963 rs11577298 chr1:87730319 G/A cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.03 -0.35 5.48e-9 Loneliness (linear analysis); CESC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.48 0.32 9.87e-8 Electroencephalogram traits; CESC cis rs7806994 1 rs7806994 chr7:56139505 A/T cg14187409 chr7:56174376 CHCHD2 0.7 6.75 0.38 9.19e-11 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg04267008 chr7:1944627 MAD1L1 -0.61 -7.6 -0.42 5.21e-13 Bipolar disorder and schizophrenia; CESC cis rs568617 0.768 rs12225345 chr11:65647105 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.94 9.55 0.51 9.22e-19 Crohn's disease; CESC cis rs938554 0.612 rs9991278 chr4:10002665 A/G cg11266682 chr4:10021025 SLC2A9 0.37 5.13 0.3 5.49e-7 Blood metabolite levels; CESC cis rs7843479 1.000 rs67385415 chr8:21853733 T/C cg17168535 chr8:21777572 XPO7 0.52 7.13 0.4 9.55e-12 Mean corpuscular volume; CESC cis rs2197308 0.610 rs10880837 chr12:37864924 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.3 0.36 1.2e-9 Morning vs. evening chronotype; CESC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg10792982 chr14:105748885 BRF1 0.42 5.59 0.32 5.74e-8 Mean platelet volume;Platelet distribution width; CESC cis rs12291225 0.679 rs7934671 chr11:14305101 C/T cg19336497 chr11:14380999 RRAS2 -0.37 -5.29 -0.31 2.58e-7 Sense of smell; CESC cis rs7551222 0.752 rs4951398 chr1:204531876 T/C cg20240347 chr1:204465584 NA -0.29 -5.8 -0.34 1.89e-8 Schizophrenia; CESC cis rs9303401 0.573 rs34097494 chr17:57171917 C/T cg12560992 chr17:57184187 TRIM37 0.5 5.21 0.3 3.78e-7 Cognitive test performance; CESC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg06028808 chr11:68637592 NA 0.43 5.12 0.3 5.87e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs5769765 0.954 rs5770707 chr22:50244533 G/A cg02269571 chr22:50332266 NA 0.46 6.07 0.35 4.43e-9 Schizophrenia; CESC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.79 -0.55 9.74e-23 Alzheimer's disease; CESC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg11890956 chr21:40555474 PSMG1 1.04 16.54 0.71 1.1e-42 Cognitive function; CESC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg24101359 chr6:42928495 GNMT 0.63 9.67 0.51 3.77e-19 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1707322 1.000 rs6677777 chr1:46475836 A/G cg06784218 chr1:46089804 CCDC17 0.39 6.56 0.37 2.87e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3741404 1.000 rs3741404 chr11:63999240 G/C cg18225595 chr11:63971243 STIP1 0.67 8.96 0.48 5.85e-17 Platelet count; CESC cis rs4654899 0.802 rs12123910 chr1:21233316 C/T cg05370193 chr1:21551575 ECE1 0.4 5.61 0.33 5.04e-8 Superior frontal gyrus grey matter volume; CESC trans rs1506636 0.854 rs6466879 chr7:123276197 G/A cg12383159 chr11:1262597 MUC5B 0.36 6.02 0.35 5.66e-9 Plateletcrit;Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06749514 chr10:114206969 VTI1A;ZDHHC6 -0.54 -7.2 -0.4 6.05e-12 Fibrinogen levels; CESC cis rs7000551 0.606 rs7844699 chr8:22248920 G/T cg12081754 chr8:22256438 SLC39A14 -0.78 -10.36 -0.54 2.41e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs11676855 0.927 rs4341884 chr2:235918504 G/T cg14917874 chr2:235941519 SH3BP4 0.42 5.44 0.32 1.2e-7 Dialysis-related mortality; CESC cis rs6456156 0.586 rs6456154 chr6:167472256 C/T cg23791538 chr6:167370224 RNASET2 -0.5 -6.44 -0.37 5.46e-10 Primary biliary cholangitis; CESC cis rs10949834 0.730 rs2237503 chr7:73509326 G/C cg07137043 chr7:73588983 EIF4H -0.69 -7.57 -0.42 6.12e-13 Verbal memory performance (residualized delayed recall change); CESC cis rs11785400 0.731 rs4736363 chr8:143742112 C/A cg24634471 chr8:143751801 JRK 0.45 5.78 0.33 2.13e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04184877 chr16:22386315 CDR2 0.6 6.52 0.37 3.55e-10 Gut microbiome composition (summer); CESC cis rs79839061 0.520 rs2279187 chr4:875529 C/T cg07828340 chr4:882639 GAK 1.04 7.65 0.43 3.68e-13 Intelligence (multi-trait analysis); CESC cis rs7216064 1.000 rs58122682 chr17:65876915 T/C cg07042672 chr17:66097459 LOC651250 -0.52 -5.4 -0.31 1.5e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7264396 0.528 rs6058370 chr20:34518592 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.78 0.38 7.81e-11 Total cholesterol levels; CESC cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg07636037 chr3:49044803 WDR6 1.03 19.61 0.77 1.59e-53 Parkinson's disease; CESC cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg21138405 chr5:131827807 IRF1 -0.38 -5.71 -0.33 3.08e-8 Breast cancer;Mosquito bite size; CESC cis rs7560272 0.529 rs2421672 chr2:73955540 G/A cg20560298 chr2:73613845 ALMS1 0.43 5.82 0.34 1.71e-8 Schizophrenia; CESC cis rs6667605 0.527 rs6673993 chr1:2552071 T/C cg20673091 chr1:2541236 MMEL1 0.47 8.28 0.45 6.16e-15 Inflammatory bowel disease;Ulcerative colitis; CESC cis rs9911578 0.967 rs12944948 chr17:56951474 A/G cg12560992 chr17:57184187 TRIM37 0.93 15.55 0.69 3.5e-39 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05265988 chr5:180688748 TRIM52 -0.45 -6.22 -0.36 1.91e-9 Fibrinogen levels; CESC cis rs9300255 0.679 rs4759409 chr12:123719585 G/C cg05973401 chr12:123451056 ABCB9 0.5 5.61 0.33 5.11e-8 Neutrophil percentage of white cells; CESC trans rs1814175 0.615 rs10839378 chr11:49806943 C/T cg03929089 chr4:120376271 NA -0.86 -13.45 -0.64 9.04e-32 Height; CESC cis rs921968 0.541 rs17572485 chr2:219296545 C/T cg02176678 chr2:219576539 TTLL4 -0.45 -7.78 -0.43 1.66e-13 Mean corpuscular hemoglobin concentration; CESC cis rs6754311 0.731 rs2164210 chr2:136580287 T/C cg15123519 chr2:136567270 LCT 0.33 5.62 0.33 4.81e-8 Mosquito bite size; CESC cis rs9457247 0.905 rs453184 chr6:167387404 A/C cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg11584989 chr19:19387371 SF4 0.38 5.12 0.3 5.98e-7 Tonsillectomy; CESC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg05368731 chr17:41323189 NBR1 0.8 10.6 0.55 3.93e-22 Menopause (age at onset); CESC cis rs9457247 0.555 rs2247325 chr6:167369992 A/G cg25258033 chr6:167368657 RNASET2 -0.36 -5.21 -0.3 3.8e-7 Crohn's disease; CESC trans rs7089973 0.549 rs34434610 chr10:116739745 A/G cg17463145 chr7:79084011 MAGI2 0.32 6.36 0.36 8.92e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs601339 1.000 rs601339 chr12:123174743 A/G cg11919336 chr12:123188078 GPR109A 0.48 6.44 0.37 5.44e-10 Adiponectin levels; CESC cis rs763014 0.931 rs11643039 chr16:634260 G/A cg00908189 chr16:619842 PIGQ 0.64 8.89 0.48 9.75e-17 Height; CESC cis rs7903847 0.642 rs11189178 chr10:99143272 T/G cg20016023 chr10:99160130 RRP12 -0.29 -5.03 -0.3 9.15e-7 Granulocyte percentage of myeloid white cells; CESC cis rs2228479 0.541 rs9806913 chr16:89953773 A/G cg04013166 chr16:89971882 TCF25 0.72 8.84 0.48 1.33e-16 Skin colour saturation; CESC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg09913183 chr17:42254507 C17orf65;ASB16 0.68 9.07 0.49 2.78e-17 Total body bone mineral density; CESC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg20476274 chr7:133979776 SLC35B4 0.62 8.86 0.48 1.15e-16 Mean platelet volume; CESC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg03467027 chr4:99064603 C4orf37 0.47 5.97 0.34 7.51e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9300255 0.543 rs1617156 chr12:123590165 T/C cg00376283 chr12:123451042 ABCB9 0.76 9.09 0.49 2.44e-17 Neutrophil percentage of white cells; CESC cis rs694739 0.734 rs663743 chr11:64107735 G/A cg02228329 chr11:64053129 BAD;GPR137 0.78 9.66 0.51 4.13e-19 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs6772849 0.901 rs9289330 chr3:128311067 C/G cg16766828 chr3:128327626 NA -0.31 -5.22 -0.31 3.64e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs9467711 0.659 rs36033628 chr6:26456074 T/G cg14345882 chr6:26364793 BTN3A2 0.66 5.26 0.31 2.98e-7 Autism spectrum disorder or schizophrenia; CESC cis rs763121 0.719 rs9610995 chr22:39057763 C/T cg06022373 chr22:39101656 GTPBP1 0.88 13.88 0.65 2.66e-33 Menopause (age at onset); CESC cis rs116988415 0.584 rs4902314 chr14:65254415 T/C cg25083366 chr14:65239357 SPTB 0.7 5.29 0.31 2.6e-7 Daytime sleep phenotypes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19902697 chr11:76494208 TSKU -0.46 -7.13 -0.4 9.33e-12 Gambling; CESC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.8 -9.12 -0.49 1.98e-17 Alzheimer's disease; CESC trans rs11098499 0.691 rs28396837 chr4:120271541 G/A cg25214090 chr10:38739885 LOC399744 0.6 8.3 0.45 5.33e-15 Corneal astigmatism; CESC trans rs12229918 0.540 rs10784460 chr12:65863584 C/T cg10754697 chr17:1504809 SLC43A2 0.48 6.04 0.35 5.3e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CESC cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg14703610 chr5:56206110 C5orf35 -0.42 -5.59 -0.32 5.75e-8 Coronary artery disease; CESC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg12463550 chr7:65579703 CRCP -0.52 -6.62 -0.38 1.94e-10 Aortic root size; CESC cis rs2279817 0.863 rs11203439 chr1:18026328 T/C cg21791023 chr1:18019539 ARHGEF10L 0.6 8.57 0.47 8.54e-16 Neuroticism; CESC cis rs11030122 0.702 rs10767715 chr11:3951409 G/T cg18678763 chr11:4115507 RRM1 -0.45 -6.05 -0.35 4.94e-9 Mean platelet volume;Platelet distribution width; CESC cis rs10924309 0.737 rs1538957 chr1:245855639 A/G cg00036263 chr1:245852353 KIF26B -0.53 -7.07 -0.4 1.39e-11 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs17376456 0.877 rs10070390 chr5:93452345 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.44 0.32 1.23e-7 Diabetic retinopathy; CESC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg25985355 chr7:65971099 NA 0.32 5.15 0.3 5.12e-7 Aortic root size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01343991 chr7:23338897 C7orf30 -0.51 -6.19 -0.36 2.28e-9 Ulcerative colitis; CESC cis rs4243830 1.000 rs12027598 chr1:6600804 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.69 5.1 0.3 6.58e-7 Body mass index; CESC cis rs9486719 1.000 rs2472890 chr6:96867646 C/T cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg14784868 chr12:69753453 YEATS4 -0.88 -13.87 -0.65 3.01e-33 Cerebrospinal fluid biomarker levels; CESC cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg18225595 chr11:63971243 STIP1 0.62 8.75 0.47 2.62e-16 Platelet count; CESC cis rs9815354 0.812 rs4547673 chr3:41952303 A/C cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.9e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg12365402 chr11:9010492 NRIP3 -0.42 -7.18 -0.4 7.05e-12 Hemoglobin concentration; CESC cis rs10927875 0.597 rs61782184 chr1:16150976 G/A cg05821634 chr1:16164109 FLJ37453 0.35 5.06 0.3 7.74e-7 Dilated cardiomyopathy; CESC trans rs4942242 1.000 rs1105856 chr13:44227067 G/T cg19169023 chr15:41853346 TYRO3 0.44 6.39 0.37 7.49e-10 Response to tocilizumab in rheumatoid arthritis; CESC trans rs7090925 1.000 rs10905373 chr10:8481266 A/G cg22997768 chr12:11092816 TAS2R14;PRR4;PRH1 0.47 6.0 0.35 6.55e-9 Systemic lupus erythematosus; CESC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg10691866 chr7:65817282 TPST1 -0.36 -5.9 -0.34 1.1e-8 Aortic root size; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg25934064 chr3:52569026 NT5DC2 0.25 5.08 0.3 7.15e-7 Hemoglobin concentration; CESC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg21926612 chr6:163149169 PACRG;PARK2 1.07 10.98 0.56 2.38e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6500602 0.653 rs4786487 chr16:4440397 C/G cg08645402 chr16:4508243 NA -0.41 -5.89 -0.34 1.17e-8 Schizophrenia; CESC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg21782813 chr7:2030301 MAD1L1 0.47 6.61 0.38 2.06e-10 Bipolar disorder and schizophrenia; CESC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.25 0.49 7.88e-18 Menopause (age at onset); CESC cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.66 0.61 4.8e-29 Colonoscopy-negative controls vs population controls; CESC cis rs9790314 1.000 rs6765269 chr3:160948542 T/C cg04691961 chr3:161091175 C3orf57 -0.4 -5.08 -0.3 7.27e-7 Morning vs. evening chronotype; CESC cis rs7714584 1.000 rs77698001 chr5:150250367 C/T cg22134413 chr5:150180641 NA 0.5 5.59 0.32 5.78e-8 Crohn's disease; CESC cis rs34779708 0.931 rs4934693 chr10:35271844 G/A cg04310649 chr10:35416472 CREM -0.5 -5.97 -0.34 7.5e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs4704187 0.687 rs6862754 chr5:74427193 T/C cg03227963 chr5:74354835 NA 0.31 5.68 0.33 3.52e-8 Response to amphetamines; CESC cis rs9359856 0.517 rs112527288 chr6:90509141 C/T cg13799429 chr6:90582589 CASP8AP2 -0.66 -6.74 -0.38 9.61e-11 Bipolar disorder; CESC cis rs1878931 0.580 rs7194596 chr16:3404408 T/A cg22508957 chr16:3507546 NAT15 -0.41 -6.04 -0.35 5.08e-9 Body mass index (adult); CESC cis rs4481887 1.000 rs4409693 chr1:248479061 C/T cg00666640 chr1:248458726 OR2T12 0.41 6.56 0.37 2.84e-10 Common traits (Other); CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg22809411 chr8:74884737 TCEB1 0.56 6.56 0.37 2.77e-10 Endometrial cancer; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg02737830 chr12:64616354 C12orf66 -0.45 -6.1 -0.35 3.76e-9 Height; CESC cis rs6842047 0.706 rs4862667 chr4:187136416 A/G cg02012338 chr4:187126139 CYP4V2 0.68 5.78 0.33 2.13e-8 Blood protein levels; CESC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg11644478 chr21:40555479 PSMG1 -0.53 -7.28 -0.41 3.78e-12 Menarche (age at onset); CESC cis rs9303280 0.901 rs9901146 chr17:38043343 G/A cg20243544 chr17:37824526 PNMT 0.52 6.82 0.39 6.16e-11 Self-reported allergy; CESC cis rs10463316 0.894 rs4099171 chr5:150766623 C/T cg03212797 chr5:150827313 SLC36A1 -0.47 -6.2 -0.36 2.17e-9 Metabolite levels (Pyroglutamine); CESC cis rs6060717 0.610 rs2590964 chr20:34613376 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.5 6.32 0.36 1.13e-9 Hip circumference adjusted for BMI; CESC cis rs9303401 0.573 rs34717648 chr17:56886624 T/A cg02118635 chr17:56770003 RAD51C;TEX14 1.0 12.54 0.61 1.28e-28 Cognitive test performance; CESC cis rs7772486 0.875 rs1412081 chr6:146409733 A/G cg23711669 chr6:146136114 FBXO30 0.81 12.17 0.6 2.27e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg17143192 chr8:8559678 CLDN23 0.45 5.56 0.32 6.52e-8 Mood instability; CESC cis rs2119480 0.701 rs1193458 chr13:111302922 T/C cg16216153 chr13:111290848 CARKD -0.36 -5.43 -0.32 1.26e-7 Diastolic blood pressure; CESC cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg15017067 chr4:17643749 FAM184B 0.39 5.57 0.32 6.24e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2806561 0.704 rs663942 chr1:23522476 G/A cg12483005 chr1:23474871 LUZP1 0.43 6.55 0.37 2.93e-10 Height; CESC trans rs875971 1.000 rs7789768 chr7:65938980 A/C cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg19346786 chr7:2764209 NA -0.5 -7.17 -0.4 7.34e-12 Height; CESC cis rs1348850 0.958 rs12471741 chr2:178448196 A/G cg23306229 chr2:178417860 TTC30B 0.54 7.07 0.4 1.38e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6669008 1.000 rs6669008 chr1:114166561 A/G cg26035817 chr1:114414802 PTPN22 0.44 6.32 0.36 1.12e-9 Bacteremia; CESC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg20243544 chr17:37824526 PNMT -0.46 -5.63 -0.33 4.6e-8 Glomerular filtration rate (creatinine); CESC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg04944784 chr2:26401820 FAM59B -0.98 -11.51 -0.58 3.85e-25 Gut microbiome composition (summer); CESC cis rs703842 0.585 rs10877022 chr12:58223937 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.58 6.64 0.38 1.8e-10 Multiple sclerosis; CESC cis rs11971779 0.688 rs1862880 chr7:139020100 T/C cg07862535 chr7:139043722 LUC7L2 0.49 5.64 0.33 4.31e-8 Diisocyanate-induced asthma; CESC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.84 0.55 6.79e-23 Alzheimer's disease; CESC cis rs2997447 0.846 rs61775425 chr1:26405634 A/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.57 5.1 0.3 6.49e-7 QRS complex (12-leadsum); CESC cis rs12220238 1.000 rs11000902 chr10:75920483 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.63 5.79 0.34 2.01e-8 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg12382846 chr20:60892121 LAMA5 -0.32 -5.06 -0.3 7.8e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs950776 0.518 rs952215 chr15:78819153 C/T cg06917634 chr15:78832804 PSMA4 -0.8 -12.2 -0.6 1.77e-27 Sudden cardiac arrest; CESC cis rs763121 0.853 rs5757234 chr22:39072686 C/T cg21395723 chr22:39101663 GTPBP1 0.49 6.73 0.38 1.07e-10 Menopause (age at onset); CESC cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg10556349 chr10:835070 NA 0.58 5.59 0.32 5.56e-8 Eosinophil percentage of granulocytes; CESC trans rs9388451 0.657 rs4895799 chr6:126052729 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.49 -6.41 -0.37 6.82e-10 Brugada syndrome; CESC cis rs963731 0.579 rs4643520 chr2:39229464 T/C cg04010122 chr2:39346883 SOS1 -0.69 -5.14 -0.3 5.41e-7 Corticobasal degeneration; CESC cis rs2415984 0.644 rs1669808 chr14:46930473 A/G cg14871534 chr14:47121158 RPL10L 0.36 5.5 0.32 8.86e-8 Number of children ever born; CESC cis rs17095355 0.818 rs11194981 chr10:111861054 A/G cg00817464 chr10:111662876 XPNPEP1 -0.49 -6.21 -0.36 2.03e-9 Biliary atresia; CESC cis rs2882667 0.858 rs11750382 chr5:138456994 A/G cg04439458 chr5:138467593 SIL1 0.35 5.58 0.32 6.01e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4975616 0.773 rs414965 chr5:1324121 G/A cg07493874 chr5:1342172 CLPTM1L -0.42 -7.93 -0.44 6.1e-14 Lung cancer; CESC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg22920501 chr2:26401640 FAM59B -0.78 -9.08 -0.49 2.58e-17 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg11764359 chr7:65958608 NA 0.79 11.32 0.57 1.67e-24 Aortic root size; CESC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg07507251 chr3:52567010 NT5DC2 0.39 6.31 0.36 1.16e-9 Bipolar disorder; CESC cis rs892961 0.932 rs9646396 chr17:75416755 G/A cg05865280 chr17:75406074 SEPT9 0.55 10.53 0.54 7.12e-22 Airflow obstruction; CESC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg02725872 chr8:58115012 NA -0.46 -7.23 -0.41 5.05e-12 Developmental language disorder (linguistic errors); CESC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.2 0.3 4.08e-7 Electroencephalogram traits; CESC cis rs6662572 0.737 rs56047133 chr1:46517228 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 5.36 0.31 1.77e-7 Blood protein levels; CESC cis rs3762637 1.000 rs28434553 chr3:122229515 C/A cg24169773 chr3:122142474 KPNA1 -0.59 -7.1 -0.4 1.16e-11 LDL cholesterol levels; CESC cis rs7264396 0.635 rs6060682 chr20:34506331 G/A cg17201900 chr20:34330562 RBM39 0.49 5.17 0.3 4.63e-7 Total cholesterol levels; CESC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.67 0.38 1.47e-10 Electroencephalogram traits; CESC cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.49 6.26 0.36 1.5e-9 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08779779 chr2:200322566 SATB2 0.59 6.73 0.38 1.02e-10 Gut microbiome composition (summer); CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg10687823 chr19:36103576 HAUS5 0.46 6.13 0.35 3.16e-9 Post-traumatic stress disorder; CESC cis rs7617480 0.648 rs6766238 chr3:48801929 G/A cg07636037 chr3:49044803 WDR6 0.8 10.94 0.56 3.04e-23 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25402685 chr13:52980264 THSD1 0.47 6.11 0.35 3.58e-9 Gut microbiome composition (summer); CESC cis rs4523957 0.928 rs403553 chr17:2191260 C/T cg16513277 chr17:2031491 SMG6 0.54 7.45 0.42 1.31e-12 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs826838 0.838 rs11183646 chr12:38799846 A/T cg13010199 chr12:38710504 ALG10B 0.6 8.53 0.46 1.1e-15 Heart rate; CESC cis rs922182 0.633 rs16947621 chr15:64271660 C/G cg24729988 chr15:64271149 DAPK2 0.47 6.68 0.38 1.41e-10 Blood protein levels; CESC cis rs919433 0.648 rs6434933 chr2:198426960 G/A cg03934865 chr2:198174659 NA 0.38 5.16 0.3 4.82e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs72781680 1.000 rs75046532 chr2:24167267 A/G cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs9291683 0.585 rs12648479 chr4:10104571 G/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.32 -0.5 4.75e-18 Bone mineral density; CESC trans rs6460942 0.915 rs7803056 chr7:12306913 A/C cg16269144 chr1:2003326 PRKCZ 0.51 6.11 0.35 3.54e-9 Coronary artery disease; CESC cis rs2933343 0.729 rs789230 chr3:128602558 G/A cg24203234 chr3:128598194 ACAD9 0.43 5.79 0.34 1.97e-8 IgG glycosylation; CESC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg20243544 chr17:37824526 PNMT -0.47 -5.8 -0.34 1.84e-8 Glomerular filtration rate (creatinine); CESC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg07507251 chr3:52567010 NT5DC2 0.32 5.56 0.32 6.75e-8 Bipolar disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11224334 chr19:53030489 ZNF808 0.45 6.63 0.38 1.89e-10 Asthma; CESC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg17949981 chr6:28129498 ZNF389 0.42 5.24 0.31 3.27e-7 Depression; CESC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg26314531 chr2:26401878 FAM59B -0.61 -6.97 -0.39 2.52e-11 Gut microbiome composition (summer); CESC cis rs7429990 0.965 rs62260764 chr3:47990500 G/C cg11946769 chr3:48343235 NME6 0.61 6.75 0.38 9.33e-11 Educational attainment (years of education); CESC cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg17366294 chr4:99064904 C4orf37 0.62 8.77 0.47 2.18e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6500395 1.000 rs9936467 chr16:48677983 T/C cg04672837 chr16:48644449 N4BP1 0.51 6.31 0.36 1.16e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs757110 0.834 rs1002226 chr11:17405617 C/T cg15432903 chr11:17409602 KCNJ11 0.65 9.4 0.5 2.69e-18 Type 2 diabetes; CESC cis rs4662945 0.603 rs13002385 chr2:130276865 T/C cg05903289 chr2:130345205 NA -0.45 -6.67 -0.38 1.5e-10 Response to cytidine analogues (gemcitabine); CESC cis rs2652822 1.000 rs1126309 chr15:63429062 A/G cg02713581 chr15:63449717 RPS27L 0.56 7.23 0.41 5.07e-12 Metabolic traits; CESC cis rs7927771 0.507 rs7119517 chr11:47675316 T/C cg18512352 chr11:47633146 NA 0.34 5.34 0.31 2.03e-7 Subjective well-being; CESC cis rs9290065 0.538 rs9840600 chr3:160769101 G/A cg03342759 chr3:160939853 NMD3 -0.4 -5.22 -0.31 3.61e-7 Kawasaki disease; CESC cis rs10129255 0.719 rs7156660 chr14:107129187 T/C cg23076370 chr14:107095027 NA -0.49 -6.73 -0.38 1.06e-10 Kawasaki disease; CESC cis rs4888262 0.526 rs8055803 chr16:74615190 A/G cg01733217 chr16:74700730 RFWD3 0.83 11.46 0.58 5.96e-25 Testicular germ cell tumor; CESC cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg07636037 chr3:49044803 WDR6 1.02 18.99 0.76 2.3e-51 Parkinson's disease; CESC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10089 1.000 rs4835944 chr5:127490870 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.72 -9.25 -0.49 7.6e-18 Ileal carcinoids; CESC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg04267008 chr7:1944627 MAD1L1 -0.74 -9.69 -0.51 3.28e-19 Bipolar disorder and schizophrenia; CESC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.65 -7.57 -0.42 6.27e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10751667 0.600 rs1128419 chr11:1010750 G/A cg20946044 chr11:1010712 AP2A2 -0.47 -6.16 -0.35 2.62e-9 Alzheimer's disease (late onset); CESC cis rs727563 0.608 rs2076200 chr22:41985956 G/T cg06481639 chr22:41940642 POLR3H -0.65 -6.38 -0.37 7.65e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg18230493 chr5:56204884 C5orf35 -0.71 -8.8 -0.48 1.77e-16 Type 2 diabetes; CESC cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 12.64 0.61 5.76e-29 Hip circumference adjusted for BMI; CESC cis rs11822910 0.871 rs2581928 chr11:57202790 A/G cg00522883 chr11:57194120 SLC43A3 -0.61 -6.91 -0.39 3.6e-11 Platelet distribution width; CESC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.42 -0.32 1.34e-7 Total body bone mineral density; CESC cis rs4909189 0.915 rs11773551 chr7:158136146 C/T cg24154853 chr7:158122151 PTPRN2 0.51 6.44 0.37 5.73e-10 Response to amphetamines; CESC cis rs72634258 0.945 rs441597 chr1:8080895 A/G cg00042356 chr1:8021962 PARK7 0.57 6.04 0.35 5.25e-9 Inflammatory bowel disease; CESC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.18 -0.3 4.5e-7 Obesity-related traits; CESC cis rs7927771 1.000 rs12361031 chr11:47783076 G/A cg20307385 chr11:47447363 PSMC3 -0.51 -6.23 -0.36 1.79e-9 Subjective well-being; CESC cis rs7107174 0.892 rs1007837 chr11:77941076 A/G cg02023728 chr11:77925099 USP35 0.38 5.53 0.32 7.66e-8 Testicular germ cell tumor; CESC cis rs9911578 1.000 rs9907499 chr17:56949044 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.16 0.3 4.87e-7 Intelligence (multi-trait analysis); CESC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg18876405 chr7:65276391 NA -0.51 -7.23 -0.41 5.17e-12 Aortic root size; CESC cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2249694 1.000 rs2515644 chr10:135353079 A/C cg20169779 chr10:135381914 SYCE1 0.39 5.2 0.3 3.9e-7 Obesity-related traits; CESC cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg08213375 chr14:104286397 PPP1R13B 0.33 5.41 0.32 1.4e-7 Reticulocyte count; CESC cis rs5753037 0.702 rs9614055 chr22:30187702 C/T cg01021169 chr22:30184971 ASCC2 -0.46 -6.57 -0.37 2.65e-10 Type 1 diabetes; CESC cis rs9487051 0.646 rs11153166 chr6:109622494 C/T cg01475377 chr6:109611718 NA 0.41 5.72 0.33 2.89e-8 Reticulocyte fraction of red cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05311119 chr4:1805090 FGFR3 0.45 6.23 0.36 1.82e-9 Fibrinogen levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01490821 chr2:170684022 UBR3 -0.44 -6.21 -0.36 2.06e-9 Gambling; CESC cis rs300703 0.935 rs300755 chr2:228505 C/T cg21211680 chr2:198530 NA 0.97 7.77 0.43 1.68e-13 Blood protein levels; CESC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg25767906 chr1:53392781 SCP2 0.43 6.05 0.35 4.94e-9 Monocyte count; CESC cis rs7520050 0.966 rs785494 chr1:46586626 C/A cg03146154 chr1:46216737 IPP -0.42 -5.42 -0.32 1.34e-7 Red blood cell count;Reticulocyte count; CESC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg00310523 chr12:86230176 RASSF9 -0.31 -5.04 -0.3 8.55e-7 Major depressive disorder; CESC cis rs60154123 0.730 rs689248 chr1:210463122 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 -0.46 -5.13 -0.3 5.47e-7 Coronary artery disease; CESC cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg05340658 chr4:99064831 C4orf37 0.83 12.9 0.62 7.07e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg11859384 chr17:80120422 CCDC57 -0.41 -5.67 -0.33 3.65e-8 Life satisfaction; CESC cis rs1348850 0.632 rs1405718 chr2:178499809 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.47 0.42 1.17e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs365132 1.000 rs1700490 chr5:176402401 G/A cg16309518 chr5:176445507 NA -0.36 -5.31 -0.31 2.33e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC trans rs9929218 0.859 rs9936682 chr16:68748223 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -9.56 -0.51 8.63e-19 Colorectal cancer; CESC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg26314531 chr2:26401878 FAM59B -0.82 -9.04 -0.49 3.33e-17 Gut microbiome composition (summer); CESC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg16545954 chr1:2118288 C1orf86 0.36 7.09 0.4 1.19e-11 Height; CESC cis rs748404 0.631 rs8042688 chr15:43638525 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.81 0.43 1.33e-13 Lung cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06852250 chr1:171750693 METTL13 -0.43 -6.0 -0.35 6.4e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2486288 0.656 rs1706768 chr15:45569443 T/C cg21132104 chr15:45694354 SPATA5L1 -0.62 -7.22 -0.41 5.34e-12 Glomerular filtration rate; CESC cis rs7814319 1.000 rs7814319 chr8:97263418 C/T cg20787634 chr8:97240163 UQCRB -0.53 -6.91 -0.39 3.66e-11 Lung function (FVC); CESC cis rs17376456 0.825 rs10064368 chr5:93266396 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.65 5.32 0.31 2.26e-7 Diabetic retinopathy; CESC cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs17376456 0.877 rs13170509 chr5:93378564 T/C cg25358565 chr5:93447407 FAM172A 1.14 10.54 0.54 6.24e-22 Diabetic retinopathy; CESC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg17143192 chr8:8559678 CLDN23 0.73 8.62 0.47 6.39e-16 Obesity-related traits; CESC cis rs7208859 0.573 rs60724269 chr17:29113273 G/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs78456975 1.000 rs28742145 chr2:1562671 T/C cg26248373 chr2:1572462 NA -0.59 -5.66 -0.33 3.87e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs60843830 1.000 rs59937473 chr2:271797 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.78 10.22 0.53 6.97e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1577917 0.771 rs2842609 chr6:86296788 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -7.8 -0.43 1.46e-13 Response to antipsychotic treatment; CESC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg08888203 chr3:10149979 C3orf24 0.48 6.1 0.35 3.84e-9 Alzheimer's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22897130 chr10:89419623 PAPSS2 0.47 6.62 0.38 2.01e-10 Gut microbiota (bacterial taxa); CESC cis rs738322 0.775 rs4375 chr22:38539041 T/C cg17652424 chr22:38574118 PLA2G6 -0.29 -5.19 -0.3 4.14e-7 Cutaneous nevi; CESC cis rs453301 0.624 rs2979265 chr8:8858717 G/C cg15556689 chr8:8085844 FLJ10661 0.49 6.35 0.36 9.2e-10 Joint mobility (Beighton score); CESC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.69 0.38 1.29e-10 Bipolar disorder; CESC trans rs28549925 0.590 rs28676827 chr7:16994780 T/C cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.74e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg21144161 chr5:423903 AHRR 0.37 6.09 0.35 3.9e-9 Cystic fibrosis severity; CESC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs7551222 0.752 rs6681905 chr1:204535789 T/G cg20240347 chr1:204465584 NA -0.29 -5.78 -0.33 2.15e-8 Schizophrenia; CESC cis rs6582630 0.599 rs7967598 chr12:38540760 C/T cg26384229 chr12:38710491 ALG10B -0.43 -5.67 -0.33 3.8e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs752010 0.714 rs2148635 chr1:42082452 C/T cg06885757 chr1:42089581 HIVEP3 -0.52 -9.07 -0.49 2.85e-17 Lupus nephritis in systemic lupus erythematosus; CESC cis rs1448094 0.817 rs7972773 chr12:86340774 A/C cg02569458 chr12:86230093 RASSF9 0.42 6.06 0.35 4.64e-9 Major depressive disorder; CESC cis rs15676 0.947 rs2997922 chr9:131580744 C/T cg00228799 chr9:131580591 ENDOG 0.45 5.67 0.33 3.76e-8 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14479329 chr6:167370587 RNASET2 0.54 7.12 0.4 1.04e-11 Gut microbiome composition (summer); CESC cis rs16866061 1.000 rs72974222 chr2:225424143 C/T cg12698349 chr2:225449008 CUL3 0.75 11.51 0.58 4.07e-25 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 12.03 0.59 6.95e-27 Platelet count; CESC cis rs3820928 0.874 rs10182307 chr2:227875360 C/T cg05526886 chr2:227700861 RHBDD1 -0.44 -5.33 -0.31 2.12e-7 Pulmonary function; CESC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg04414720 chr1:150670196 GOLPH3L 0.48 6.29 0.36 1.33e-9 Melanoma; CESC trans rs629535 0.814 rs62513373 chr8:70080753 C/T cg21567404 chr3:27674614 NA -0.89 -10.53 -0.54 6.98e-22 Dupuytren's disease; CESC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.99 -0.35 6.88e-9 Parkinson's disease; CESC cis rs13385 0.769 rs13178142 chr5:139596552 C/T cg26211634 chr5:139558579 C5orf32 0.47 5.31 0.31 2.35e-7 Atrial fibrillation; CESC cis rs9457247 1.000 rs365189 chr6:167384545 G/A cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 5.12e-16 Crohn's disease; CESC cis rs3818285 0.504 rs7100154 chr10:111650150 T/C cg00817464 chr10:111662876 XPNPEP1 -0.51 -7.08 -0.4 1.26e-11 Superior crus of antihelix expression; CESC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg01516881 chr6:292596 DUSP22 -0.84 -11.6 -0.58 1.89e-25 Menopause (age at onset); CESC cis rs116095464 0.558 rs6874745 chr5:264527 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.86e-15 Breast cancer; CESC cis rs11997175 0.646 rs6468195 chr8:33724817 A/G ch.8.33884649F chr8:33765107 NA 0.56 7.36 0.41 2.25e-12 Body mass index; CESC trans rs62103177 0.608 rs59300126 chr18:77694439 C/A cg05926928 chr17:57297772 GDPD1 0.87 8.21 0.45 9.47e-15 Opioid sensitivity; CESC trans rs17685 0.753 rs1637051 chr7:75730659 G/A cg19862616 chr7:65841803 NCRNA00174 0.87 12.7 0.62 3.58e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs78889164 0.830 rs8111027 chr19:33877523 C/G cg02272751 chr19:33882848 PEPD -0.55 -7.64 -0.42 4.08e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs12348691 0.503 rs10983975 chr9:100614188 A/C cg13688889 chr9:100608707 NA -0.9 -13.65 -0.64 1.78e-32 Alopecia areata; CESC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg11764359 chr7:65958608 NA -0.8 -11.71 -0.58 8.38e-26 Aortic root size; CESC cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg05347473 chr6:146136440 FBXO30 0.59 7.56 0.42 6.43e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs9818941 1.000 rs9818941 chr3:157686457 G/A cg08654915 chr3:157813417 NA -0.44 -7.54 -0.42 7.3e-13 Height; CESC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg13393036 chr8:95962371 TP53INP1 -0.51 -11.09 -0.56 9.71e-24 Type 2 diabetes; CESC cis rs963731 0.649 rs74258982 chr2:39344474 T/C cg04010122 chr2:39346883 SOS1 0.72 5.04 0.3 8.77e-7 Corticobasal degeneration; CESC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg12463550 chr7:65579703 CRCP -0.54 -6.98 -0.39 2.4e-11 Aortic root size; CESC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2929278 0.562 rs8033846 chr15:44035363 A/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.54 -7.18 -0.4 7.19e-12 Schizophrenia; CESC cis rs2455799 0.634 rs11128765 chr3:15903331 G/T cg16303742 chr3:15540471 COLQ -0.38 -5.91 -0.34 1.03e-8 Mean platelet volume; CESC cis rs6599388 0.803 rs11248057 chr4:906131 C/G cg23939001 chr4:940644 TMEM175 -0.48 -6.41 -0.37 6.58e-10 Parkinson's disease; CESC cis rs4566357 1.000 rs2141829 chr2:227922454 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -5.37 -0.31 1.68e-7 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08585351 chr13:22178326 EFHA1 -0.46 -6.05 -0.35 4.94e-9 Ulcerative colitis; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24394020 chr22:50354019 PIM3 0.49 6.24 0.36 1.75e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg23048001 chr7:2026167 MAD1L1 -0.47 -6.07 -0.35 4.36e-9 Bipolar disorder and schizophrenia; CESC cis rs113835537 0.529 rs11227512 chr11:66281291 T/C cg22134325 chr11:66188745 NPAS4 0.37 5.81 0.34 1.77e-8 Airway imaging phenotypes; CESC cis rs11690935 0.632 rs35854151 chr2:172657439 G/A cg13550731 chr2:172543902 DYNC1I2 0.55 7.6 0.42 4.99e-13 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18654971 chr5:54469363 MIR449C;CDC20B -0.43 -6.14 -0.35 3.03e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00414561 chr15:23034473 NIPA2 0.6 7.12 0.4 1.04e-11 Gut microbiome composition (summer); CESC cis rs8017423 0.866 rs10184 chr14:90744672 G/A cg14092571 chr14:90743983 NA 0.56 8.3 0.45 5.43e-15 Mortality in heart failure; CESC cis rs10089 1.000 rs13357268 chr5:127423051 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.16 0.53 1.05e-20 Ileal carcinoids; CESC trans rs7246760 1.000 rs12460571 chr19:9881746 C/A cg02900749 chr2:68251473 NA -0.74 -6.78 -0.38 7.89e-11 Pursuit maintenance gain; CESC cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9398803 0.965 rs2326387 chr6:126680489 G/A cg19875578 chr6:126661172 C6orf173 0.48 6.73 0.38 1.06e-10 Male-pattern baldness; CESC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg17971929 chr21:40555470 PSMG1 -0.6 -7.91 -0.44 7.15e-14 Menarche (age at onset); CESC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg13607699 chr17:42295918 UBTF 0.56 7.08 0.4 1.31e-11 Total body bone mineral density; CESC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.41e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1153858 1.000 rs12437887 chr15:45669094 G/A cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs988913 0.723 rs75537920 chr6:54999717 T/C cg03513858 chr6:54763001 FAM83B 0.34 5.2 0.3 4.05e-7 Menarche (age at onset); CESC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.07 -0.3 7.43e-7 Bipolar disorder; CESC cis rs9818941 0.748 rs12634315 chr3:157728016 T/C cg08654915 chr3:157813417 NA -0.45 -7.54 -0.42 7.43e-13 Height; CESC cis rs9300255 0.568 rs1047158 chr12:123644056 C/A cg19016782 chr12:123741754 C12orf65 -0.4 -5.77 -0.33 2.27e-8 Neutrophil percentage of white cells; CESC cis rs1881797 0.932 rs4551631 chr1:247667663 C/T cg18198730 chr1:247681584 NA -0.66 -8.59 -0.47 7.7e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg17211192 chr8:82754475 SNX16 -0.59 -7.69 -0.43 2.94e-13 Diastolic blood pressure; CESC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg19391498 chr2:38892846 GALM -0.52 -6.74 -0.38 1.01e-10 5-HTT brain serotonin transporter levels; CESC cis rs7107174 1.000 rs2510051 chr11:77981171 A/C cg02023728 chr11:77925099 USP35 0.48 6.86 0.39 4.75e-11 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9399137 0.507 rs7761964 chr6:135314265 T/C cg24558204 chr6:135376177 HBS1L 0.72 10.08 0.53 1.92e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.03e-9 Aortic root size; CESC trans rs1728785 0.818 rs1170430 chr16:68604954 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.93 0.44 6e-14 Ulcerative colitis; CESC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg17724175 chr1:150552817 MCL1 0.43 6.47 0.37 4.66e-10 Melanoma; CESC cis rs7520050 0.778 rs2934857 chr1:46039612 A/G cg24296786 chr1:45957014 TESK2 -0.46 -5.93 -0.34 9.54e-9 Red blood cell count;Reticulocyte count; CESC cis rs6964587 1.000 rs57816416 chr7:91736078 A/C cg17063962 chr7:91808500 NA 0.56 7.69 0.43 2.96e-13 Breast cancer; CESC cis rs9858542 0.953 rs7648841 chr3:49416825 G/A cg03060546 chr3:49711283 APEH -0.53 -6.04 -0.35 5.23e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs10465746 0.967 rs11163879 chr1:84444051 T/C cg10977910 chr1:84465055 TTLL7 0.47 6.43 0.37 6.02e-10 Obesity-related traits; CESC trans rs208520 0.690 rs4618506 chr6:66756889 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.9 -11.53 -0.58 3.38e-25 Exhaled nitric oxide output; CESC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg15787769 chr11:842744 TSPAN4;POLR2L -0.69 -8.78 -0.47 2.11e-16 Mean platelet volume; CESC cis rs6088590 0.603 rs6579186 chr20:33282198 G/C cg08999081 chr20:33150536 PIGU 0.65 10.66 0.55 2.54e-22 Coronary artery disease; CESC cis rs9303401 0.632 rs7222087 chr17:57221619 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.56 7.31 0.41 3.2e-12 Cognitive test performance; CESC cis rs57221529 0.766 rs72706606 chr5:558609 T/C cg16447950 chr5:562315 NA -0.7 -7.76 -0.43 1.9e-13 Lung disease severity in cystic fibrosis; CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg07308232 chr7:1071921 C7orf50 -0.38 -5.05 -0.3 8.19e-7 Longevity;Endometriosis; CESC cis rs2228479 0.618 rs62052174 chr16:89950901 G/A cg04013166 chr16:89971882 TCF25 0.77 7.14 0.4 8.86e-12 Skin colour saturation; CESC cis rs3892630 0.824 rs2287884 chr19:33321447 A/G cg13157960 chr19:33183277 NUDT19 0.54 5.13 0.3 5.73e-7 Red blood cell traits; CESC cis rs7130144 0.541 rs1950119 chr11:130462002 A/T cg26307797 chr11:130446613 NA 0.65 6.04 0.35 5.26e-9 Urate levels in lean individuals; CESC cis rs4699052 1.000 rs6533060 chr4:104139996 T/C cg16532752 chr4:104119610 CENPE -0.39 -5.42 -0.32 1.35e-7 Testicular germ cell tumor; CESC cis rs713587 0.521 rs35177510 chr2:25089594 C/A cg01884057 chr2:25150051 NA 0.35 6.67 0.38 1.46e-10 Body mass index in non-asthmatics; CESC cis rs4930103 0.591 rs11042048 chr11:1986240 C/G cg23202291 chr11:1979235 NA 0.41 5.83 0.34 1.62e-8 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs2637266 0.703 rs846641 chr10:78524136 C/T cg18941641 chr10:78392320 NA 0.39 7.5 0.42 9.46e-13 Pulmonary function; CESC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.62 8.73 0.47 2.84e-16 Bipolar disorder; CESC cis rs854765 0.583 rs4077198 chr17:17834563 T/C cg04398451 chr17:18023971 MYO15A -0.67 -9.61 -0.51 6.01e-19 Total body bone mineral density; CESC cis rs2979489 0.891 rs2979498 chr8:30375251 T/A cg26383811 chr8:30366931 RBPMS -0.8 -9.88 -0.52 8.22e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg07697082 chr8:82753677 SNX16 -0.39 -5.98 -0.35 7.01e-9 Diastolic blood pressure; CESC cis rs6088580 0.634 rs6059878 chr20:33087166 A/T cg24642439 chr20:33292090 TP53INP2 0.51 6.62 0.38 1.99e-10 Glomerular filtration rate (creatinine); CESC cis rs8141529 0.748 rs9620841 chr22:29290981 C/T cg02153584 chr22:29168773 CCDC117 0.59 7.84 0.43 1.09e-13 Lymphocyte counts; CESC cis rs861020 0.771 rs674804 chr1:210014603 C/G cg05527609 chr1:210001259 C1orf107 1.09 15.51 0.69 4.93e-39 Orofacial clefts; CESC trans rs66573146 0.572 rs67922134 chr4:6955772 G/A cg07817883 chr1:32538562 TMEM39B 1.25 8.67 0.47 4.33e-16 Granulocyte percentage of myeloid white cells; CESC cis rs2425143 1.000 rs56116518 chr20:34286251 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.11 0.3 6.03e-7 Blood protein levels; CESC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg06873352 chr17:61820015 STRADA 0.48 7.02 0.4 1.81e-11 Height; CESC cis rs992157 0.661 rs17653757 chr2:219109364 G/C cg00012203 chr2:219082015 ARPC2 0.85 12.31 0.6 7.75e-28 Colorectal cancer; CESC cis rs7264396 0.635 rs6060681 chr20:34506147 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.58 7.14 0.4 8.92e-12 Total cholesterol levels; CESC cis rs7927771 0.524 rs6485763 chr11:47627302 C/T cg20307385 chr11:47447363 PSMC3 0.65 8.97 0.48 5.58e-17 Subjective well-being; CESC cis rs28386778 0.700 rs12449555 chr17:62003982 T/A cg06873352 chr17:61820015 STRADA -0.63 -10.1 -0.53 1.69e-20 Prudent dietary pattern; CESC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg17971929 chr21:40555470 PSMG1 1.07 16.33 0.71 5.97e-42 Cognitive function; CESC cis rs72781680 0.898 rs72782137 chr2:24047805 C/T cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15342139 chr6:170124938 PHF10 0.62 7.18 0.4 6.93e-12 Gut microbiome composition (summer); CESC cis rs12824058 0.831 rs4759657 chr12:130815818 G/A cg26677194 chr12:130822605 PIWIL1 0.52 6.82 0.39 6.23e-11 Menopause (age at onset); CESC cis rs7617773 0.780 rs11714176 chr3:48360862 C/T cg11946769 chr3:48343235 NME6 0.89 12.34 0.6 5.98e-28 Coronary artery disease; CESC cis rs2228479 0.702 rs17233441 chr16:89817998 C/G cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg05555928 chr11:63887634 MACROD1 0.37 5.48 0.32 9.98e-8 Platelet count; CESC cis rs933688 0.818 rs10052492 chr5:90759930 T/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 13.7 0.64 1.12e-32 Smoking behavior; CESC cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg12311346 chr5:56204834 C5orf35 0.64 8.49 0.46 1.47e-15 Initial pursuit acceleration; CESC trans rs561341 1.000 rs527256 chr17:30321293 C/G cg20587970 chr11:113659929 NA -1.44 -18.71 -0.75 2.25e-50 Hip circumference adjusted for BMI; CESC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs6429082 0.783 rs291365 chr1:235688043 A/G cg26050004 chr1:235667680 B3GALNT2 0.66 8.81 0.48 1.67e-16 Adiposity; CESC cis rs1006703 0.544 rs35299172 chr17:3834598 C/T cg06463185 chr17:3833770 ATP2A3 0.56 6.06 0.35 4.59e-9 Glucose homeostasis traits; CESC cis rs933688 1.000 rs1035476 chr5:90745976 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 12.5 0.61 1.76e-28 Smoking behavior; CESC cis rs11785400 1.000 rs4327844 chr8:143733540 C/T cg24634471 chr8:143751801 JRK -0.46 -6.11 -0.35 3.49e-9 Schizophrenia; CESC cis rs7098414 0.531 rs4120852 chr10:82018594 G/T cg00277334 chr10:82204260 NA -0.47 -6.11 -0.35 3.5e-9 Post bronchodilator FEV1; CESC cis rs1881797 0.872 rs12404733 chr1:247690417 A/C cg11166453 chr1:247681781 NA 0.48 6.82 0.39 6.26e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs3733585 0.699 rs1122142 chr4:9947548 G/C cg02734326 chr4:10020555 SLC2A9 -0.42 -5.84 -0.34 1.49e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1707322 0.721 rs12069121 chr1:46231984 G/A cg03146154 chr1:46216737 IPP 0.81 11.48 0.58 4.89e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4722166 0.630 rs7808457 chr7:22798265 A/T cg05472934 chr7:22766657 IL6 -0.87 -10.38 -0.54 2.11e-21 Lung cancer; CESC cis rs8060686 0.858 rs20549 chr16:67969930 A/G cg26727032 chr16:67993705 SLC12A4 -0.64 -9.33 -0.5 4.45e-18 HDL cholesterol;Metabolic syndrome; CESC cis rs12325245 0.536 rs34737210 chr16:58549262 T/C cg02549819 chr16:58548995 SETD6 0.97 6.12 0.35 3.44e-9 Schizophrenia; CESC cis rs7474896 0.583 rs10764144 chr10:37975732 G/C cg00409905 chr10:38381863 ZNF37A -0.45 -5.28 -0.31 2.75e-7 Obesity (extreme); CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg13789711 chr9:139743225 PHPT1 0.48 6.41 0.37 6.66e-10 Obesity-related traits; CESC cis rs7923609 0.756 rs7080386 chr10:65048306 C/A cg01631684 chr10:65280961 REEP3 -0.45 -5.64 -0.33 4.38e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7542091 0.704 rs7537294 chr1:210043777 A/G cg22029157 chr1:209979665 IRF6 0.5 7.98 0.44 4.32e-14 Monobrow; CESC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg22920501 chr2:26401640 FAM59B -0.79 -9.59 -0.51 6.87e-19 Gut microbiome composition (summer); CESC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg15145296 chr3:125709740 NA -0.54 -5.73 -0.33 2.67e-8 Blood pressure (smoking interaction); CESC cis rs561341 0.769 rs12941700 chr17:30185022 A/G cg12193833 chr17:30244370 NA 0.55 5.31 0.31 2.35e-7 Hip circumference adjusted for BMI; CESC cis rs7582720 1.000 rs72936304 chr2:204036357 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 6.87 0.39 4.55e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7560272 0.723 rs4346412 chr2:73843571 A/G cg20560298 chr2:73613845 ALMS1 -0.51 -7.19 -0.4 6.42e-12 Schizophrenia; CESC cis rs901683 1.000 rs34897497 chr10:46024677 A/G cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg19077165 chr18:44547161 KATNAL2 -0.62 -9.37 -0.5 3.23e-18 Personality dimensions; CESC cis rs2797160 1.000 rs1777222 chr6:126021030 C/T cg05901451 chr6:126070800 HEY2 0.44 6.4 0.37 7.13e-10 Endometrial cancer; CESC cis rs916888 0.773 rs199533 chr17:44828931 G/A cg17911788 chr17:44343683 NA -0.59 -7.77 -0.43 1.75e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs863345 0.967 rs7534319 chr1:158532295 G/C cg12129480 chr1:158549410 OR10X1 -0.33 -6.66 -0.38 1.57e-10 Pneumococcal bacteremia; CESC cis rs17401966 0.931 rs12130563 chr1:10428452 G/A cg15208524 chr1:10270712 KIF1B 0.4 5.12 0.3 6e-7 Hepatocellular carcinoma; CESC cis rs3768617 0.565 rs10752898 chr1:183077896 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.25 0.63 4.34e-31 Fuchs's corneal dystrophy; CESC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg21285383 chr16:89894308 SPIRE2 0.32 5.8 0.34 1.86e-8 Vitiligo; CESC cis rs1953600 0.668 rs7091565 chr10:81913561 A/G cg04850286 chr10:81895943 PLAC9 -0.29 -5.1 -0.3 6.32e-7 Sarcoidosis; CESC cis rs72949976 0.864 rs13389834 chr2:214025112 G/A cg08319019 chr2:214017104 IKZF2 -0.45 -5.5 -0.32 9e-8 Lung cancer;Squamous cell lung carcinoma; CESC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg22535103 chr8:58192502 C8orf71 -0.96 -9.82 -0.52 1.3e-19 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.908 rs7695996 chr4:120322033 C/T cg09307838 chr4:120376055 NA 0.91 12.48 0.61 2.07e-28 Corneal astigmatism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14967814 chr3:179041370 ZNF639 -0.43 -6.1 -0.35 3.72e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24324755 chr1:44115813 KDM4A -0.44 -6.29 -0.36 1.29e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13256369 0.802 rs13256404 chr8:8562974 T/C cg00074818 chr8:8560427 CLDN23 0.38 5.46 0.32 1.1e-7 Obesity-related traits; CESC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg24829409 chr8:58192753 C8orf71 -0.78 -10.28 -0.53 4.36e-21 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs30380 1.000 rs27529 chr5:96126308 A/G cg16492584 chr5:96139282 ERAP1 -0.35 -5.13 -0.3 5.6e-7 Cerebrospinal fluid biomarker levels; CESC cis rs9325144 0.600 rs6582630 chr12:38743508 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.08 -0.44 2.26e-14 Morning vs. evening chronotype; CESC cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg22875332 chr1:76189707 ACADM -0.76 -11.73 -0.58 6.93e-26 Blood metabolite levels;Acylcarnitine levels; CESC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.88 10.19 0.53 8.59e-21 Mean platelet volume; CESC cis rs8072100 0.713 rs11079776 chr17:45546893 C/T cg08085267 chr17:45401833 C17orf57 -0.54 -6.83 -0.39 5.68e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00784703 chr21:45139229 PDXK 0.69 7.84 0.43 1.1e-13 Gut microbiome composition (summer); CESC cis rs778371 0.834 rs778364 chr2:233777859 A/G cg08000102 chr2:233561755 GIGYF2 0.64 8.25 0.45 7.54e-15 Schizophrenia; CESC cis rs7116495 0.609 rs949323 chr11:71714528 T/G cg26138937 chr11:71823887 C11orf51 -1.16 -7.82 -0.43 1.29e-13 Severe influenza A (H1N1) infection; CESC trans rs7607369 0.680 rs533760 chr2:219381405 T/C cg15547669 chr20:2781122 CPXM1 0.36 6.03 0.35 5.54e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs1153858 1.000 rs11852800 chr15:45639131 A/G cg14582100 chr15:45693742 SPATA5L1 -0.43 -6.08 -0.35 4.2e-9 Homoarginine levels; CESC cis rs4722166 0.695 rs7808122 chr7:22798080 A/G cg05265849 chr7:22767390 IL6 0.45 6.22 0.36 1.93e-9 Lung cancer; CESC cis rs4664308 0.905 rs62175518 chr2:160915149 C/T cg03641300 chr2:160917029 PLA2R1 -0.63 -9.44 -0.5 1.98e-18 Idiopathic membranous nephropathy; CESC cis rs10256972 0.527 rs28671326 chr7:1174973 G/A cg09177884 chr7:1199841 ZFAND2A -0.59 -7.72 -0.43 2.38e-13 Longevity;Endometriosis; CESC cis rs1790761 0.692 rs611663 chr11:67312221 C/T cg00290607 chr11:67383545 NA 0.4 5.72 0.33 2.9e-8 Mean corpuscular volume; CESC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.15e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4664304 0.781 rs6432570 chr2:160808314 A/G cg03641300 chr2:160917029 PLA2R1 -0.41 -5.47 -0.32 1.06e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg18099408 chr3:52552593 STAB1 -0.31 -5.16 -0.3 4.81e-7 Bipolar disorder; CESC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs763121 0.853 rs6001184 chr22:39052116 C/T cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.54e-7 Menopause (age at onset); CESC cis rs75887402 1.000 rs1428387 chr5:122705244 A/G cg27033705 chr5:122759302 CEP120 -0.89 -5.95 -0.34 8.67e-9 Breast cancer; CESC cis rs4906332 1.000 rs1951389 chr14:103898525 G/C cg09975044 chr14:104007538 NA 0.47 6.4 0.37 6.89e-10 Coronary artery disease; CESC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg13880726 chr7:1868755 MAD1L1 0.53 7.0 0.4 2.07e-11 Bipolar disorder and schizophrenia; CESC cis rs9470366 0.816 rs7742159 chr6:36619452 A/C cg08179530 chr6:36648295 CDKN1A 0.54 6.3 0.36 1.21e-9 QRS duration; CESC trans rs9650657 0.513 rs4841459 chr8:10782442 A/C cg06636001 chr8:8085503 FLJ10661 -0.51 -6.35 -0.36 9.17e-10 Neuroticism; CESC cis rs4835473 0.932 rs6826862 chr4:144899333 A/G cg25736465 chr4:144833511 NA 0.39 6.05 0.35 4.91e-9 Immature fraction of reticulocytes; CESC cis rs6546550 0.901 rs11893500 chr2:70154187 T/C cg02498382 chr2:70120550 SNRNP27 -0.4 -6.95 -0.39 2.78e-11 Prevalent atrial fibrillation; CESC cis rs782590 0.683 rs782633 chr2:55898203 A/G cg18811423 chr2:55921094 PNPT1 0.78 12.9 0.62 7e-30 Metabolic syndrome; CESC cis rs412000 0.554 rs2680700 chr17:56440542 G/T cg25039879 chr17:56429692 SUPT4H1 0.58 7.27 0.41 4.04e-12 Primary tooth development (time to first tooth eruption); CESC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg05564831 chr3:52568323 NT5DC2 -0.39 -5.99 -0.35 6.88e-9 Electroencephalogram traits; CESC cis rs7584330 0.910 rs72620830 chr2:238396985 C/T cg11271282 chr2:238384023 NA 0.48 5.6 0.33 5.34e-8 Prostate cancer; CESC trans rs9467711 0.659 rs34605993 chr6:26454363 C/T cg06606381 chr12:133084897 FBRSL1 -0.97 -7.05 -0.4 1.58e-11 Autism spectrum disorder or schizophrenia; CESC trans rs9929218 0.953 rs17772411 chr16:68810923 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.6 -7.78 -0.43 1.6e-13 Colorectal cancer; CESC cis rs2273669 0.667 rs9688496 chr6:109364825 G/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg04369109 chr6:150039330 LATS1 -0.41 -5.64 -0.33 4.35e-8 Lung cancer; CESC cis rs8013055 0.796 rs11628497 chr14:105970789 C/T cg23356831 chr14:105996513 TMEM121 0.37 5.11 0.3 6.19e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC cis rs868036 0.718 rs2241420 chr15:68082816 G/A cg08079166 chr15:68083412 MAP2K5 0.35 5.1 0.3 6.47e-7 Restless legs syndrome; CESC cis rs9486715 1.000 rs9386670 chr6:97060688 C/A cg06623918 chr6:96969491 KIAA0776 -0.86 -11.98 -0.59 9.94e-27 Headache; CESC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg05564831 chr3:52568323 NT5DC2 0.45 6.9 0.39 3.86e-11 Bipolar disorder; CESC trans rs17685 0.753 rs1637044 chr7:75703744 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.47 0.61 2.13e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2933343 1.000 rs789213 chr3:128616359 C/G cg25356066 chr3:128598488 ACAD9 -0.58 -7.34 -0.41 2.7e-12 IgG glycosylation; CESC cis rs6495122 0.699 rs12905199 chr15:75070196 A/G cg09165964 chr15:75287851 SCAMP5 0.4 5.22 0.31 3.65e-7 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs17376456 0.877 rs13170509 chr5:93378564 T/C cg21475434 chr5:93447410 FAM172A 0.84 7.15 0.4 8.34e-12 Diabetic retinopathy; CESC trans rs3934047 0.904 rs28403489 chr15:82010502 A/G cg17156767 chr19:30364462 NA 0.38 6.04 0.35 5.15e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg05564831 chr3:52568323 NT5DC2 0.45 6.97 0.39 2.55e-11 Bipolar disorder; CESC cis rs4481887 0.927 rs4347240 chr1:248475403 C/G cg00666640 chr1:248458726 OR2T12 0.36 6.12 0.35 3.33e-9 Common traits (Other); CESC cis rs12497850 0.931 rs11920534 chr3:48937761 G/T cg06212747 chr3:49208901 KLHDC8B 0.68 9.38 0.5 3.06e-18 Parkinson's disease; CESC cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg24818145 chr4:99064322 C4orf37 0.39 5.08 0.3 7.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10779751 0.632 rs2748876 chr1:11134157 T/G cg08854313 chr1:11322531 MTOR 0.74 8.83 0.48 1.43e-16 Body mass index; CESC cis rs9611565 0.546 rs739129 chr22:42118249 G/A cg17376030 chr22:41985996 PMM1 -0.78 -8.45 -0.46 1.98e-15 Vitiligo; CESC cis rs6439153 0.967 rs12695513 chr3:128722312 T/C cg24203234 chr3:128598194 ACAD9 0.4 5.29 0.31 2.56e-7 Pneumococcal bacteremia; CESC cis rs7044106 0.762 rs3903886 chr9:123383646 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.66 -9.71 -0.51 2.85e-19 Hip circumference adjusted for BMI; CESC cis rs10203711 1.000 rs907102 chr2:239564503 G/A cg14580085 chr2:239553406 NA 0.34 5.1 0.3 6.6e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg04944784 chr2:26401820 FAM59B -0.66 -7.66 -0.43 3.61e-13 Gut microbiome composition (summer); CESC cis rs12291225 0.639 rs61883858 chr11:14294708 C/T cg19336497 chr11:14380999 RRAS2 -0.37 -5.37 -0.31 1.68e-7 Sense of smell; CESC cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.79 8.26 0.45 6.82e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs523522 0.962 rs4767905 chr12:120930835 C/T cg27279351 chr12:120934652 DYNLL1 0.69 9.13 0.49 1.8e-17 High light scatter reticulocyte count; CESC trans rs4295623 0.585 rs34421088 chr8:11589042 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -6.31 -0.36 1.15e-9 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.59 0.64 2.72e-32 Prudent dietary pattern; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15356780 chr14:90422831 TDP1 0.47 6.3 0.36 1.23e-9 Systemic lupus erythematosus; CESC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg00166722 chr3:10149974 C3orf24 0.54 6.89 0.39 4.08e-11 Alzheimer's disease; CESC cis rs2985684 0.895 rs4900940 chr14:50075310 A/C cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.48 -5.66 -0.33 3.92e-8 Carotid intima media thickness; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09929564 chr1:153643582 ILF2 -0.47 -6.55 -0.37 2.93e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs35146811 0.625 rs858514 chr7:99825748 A/G cg13215871 chr17:75784724 NA -0.34 -6.23 -0.36 1.8e-9 Coronary artery disease; CESC cis rs10771431 0.597 rs3759275 chr12:9353828 A/T cg08997352 chr12:9597637 DDX12 -0.7 -8.86 -0.48 1.17e-16 Breast size; CESC cis rs477692 0.604 rs1008982 chr10:131445731 T/C cg24747557 chr10:131355152 MGMT 0.37 5.1 0.3 6.41e-7 Response to temozolomide; CESC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 13.21 0.63 5.99e-31 Platelet count; CESC cis rs7666738 0.791 rs34790496 chr4:98930516 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.33 0.31 2.13e-7 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17446216 chr1:32480239 KHDRBS1 0.38 6.02 0.35 5.83e-9 Gambling; CESC cis rs708547 0.957 rs2458552 chr4:57773442 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -5.35 -0.31 1.88e-7 Response to bleomycin (chromatid breaks); CESC trans rs875971 0.895 rs10755833 chr7:65913917 A/G cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC trans rs35110281 0.744 rs230644 chr21:44917183 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.46 -6.08 -0.35 4.23e-9 Mean corpuscular volume; CESC cis rs13191362 1.000 rs35424047 chr6:163029715 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.86 9.12 0.49 1.91e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs112790992 1 rs112790992 chr14:105758217 A/C cg27165867 chr14:105738592 BRF1 -0.47 -5.55 -0.32 6.92e-8 Platelet count; CESC cis rs9457247 0.902 rs34560498 chr6:167395862 A/G cg23791538 chr6:167370224 RNASET2 -0.6 -8.51 -0.46 1.35e-15 Crohn's disease; CESC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg08027265 chr7:2291960 NA -0.45 -6.92 -0.39 3.42e-11 Bipolar disorder and schizophrenia; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg19875216 chr3:133524841 SRPRB -0.42 -6.08 -0.35 4.22e-9 Vertical cup-disc ratio; CESC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg20151795 chr6:28129481 ZNF389 0.41 5.28 0.31 2.69e-7 Depression; CESC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg19592336 chr6:28129416 ZNF389 0.58 7.71 0.43 2.54e-13 Parkinson's disease; CESC cis rs758324 0.947 rs2404778 chr5:131172886 T/C cg06307176 chr5:131281290 NA 0.42 5.08 0.3 7.13e-7 Alzheimer's disease in APOE e4- carriers; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01716223 chr13:53023979 VPS36 0.47 6.21 0.36 2.07e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2735413 0.837 rs12920830 chr16:78083149 A/C cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs3540 0.554 rs4244879 chr15:91066915 C/T cg22089800 chr15:90895588 ZNF774 -0.64 -8.42 -0.46 2.39e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.87 9.04 0.49 3.35e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs9467711 0.606 rs9348726 chr6:26605206 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.71 6.05 0.35 5.04e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2011503 0.941 rs998732 chr19:19378671 A/G cg11584989 chr19:19387371 SF4 0.63 7.58 0.42 5.75e-13 Bipolar disorder; CESC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg19046167 chr17:80928561 B3GNTL1 -0.41 -5.04 -0.3 8.77e-7 Breast cancer; CESC cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.77 0.33 2.21e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6088590 0.561 rs6088527 chr20:33155841 C/T cg06115741 chr20:33292138 TP53INP2 0.51 6.51 0.37 3.74e-10 Coronary artery disease; CESC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg11644478 chr21:40555479 PSMG1 0.92 13.73 0.64 8.83e-33 Cognitive function; CESC cis rs897984 0.806 rs11150600 chr16:30940331 C/T cg02466173 chr16:30829666 NA 0.49 8.33 0.46 4.26e-15 Dementia with Lewy bodies; CESC cis rs3771570 0.892 rs62186433 chr2:242257835 A/G cg21155796 chr2:242212141 HDLBP 0.6 5.12 0.3 5.96e-7 Prostate cancer; CESC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.86 0.34 1.4e-8 Electroencephalogram traits; CESC cis rs4727027 0.769 rs10952797 chr7:148816722 A/T cg23158103 chr7:148848205 ZNF398 -0.41 -6.83 -0.39 5.9e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg02038168 chr22:39784481 NA -0.62 -7.88 -0.44 8.34e-14 Intelligence (multi-trait analysis); CESC cis rs754466 0.914 rs4595491 chr10:79685833 G/A cg17075019 chr10:79541650 NA -0.77 -9.42 -0.5 2.33e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs939658 0.875 rs2177057 chr15:79441441 G/C cg17916960 chr15:79447300 NA -0.35 -5.98 -0.34 7.25e-9 Refractive error; CESC cis rs6690583 0.562 rs6688354 chr1:85520854 A/G cg22488158 chr1:85528044 WDR63 0.57 5.53 0.32 7.72e-8 Serum sulfate level; CESC cis rs6565681 1.000 rs4889848 chr17:78354661 C/T cg15383979 chr17:78362278 RNF213;LOC100294362 -0.77 -8.8 -0.48 1.75e-16 Moyamoya disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15260365 chr11:67771606 UNC93B1 0.43 6.04 0.35 5.06e-9 Gut microbiota (bacterial taxa); CESC cis rs3126085 0.935 rs3126048 chr1:152260165 T/C cg03465714 chr1:152285911 FLG 0.46 5.74 0.33 2.61e-8 Atopic dermatitis; CESC cis rs9309473 0.607 rs6740173 chr2:73602266 C/G cg20560298 chr2:73613845 ALMS1 -0.52 -7.34 -0.41 2.65e-12 Metabolite levels; CESC cis rs9486715 0.867 rs926277 chr6:96868837 T/A cg18709589 chr6:96969512 KIAA0776 0.45 6.46 0.37 5.05e-10 Headache; CESC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg14893161 chr1:205819251 PM20D1 -0.79 -11.4 -0.57 9.31e-25 Menarche (age at onset); CESC cis rs12422267 0.536 rs11246933 chr12:132610314 G/A cg09764611 chr12:132620959 NA -0.58 -6.86 -0.39 4.85e-11 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs2795502 0.935 rs2744060 chr10:43262616 C/G cg20628663 chr10:43360327 NA -0.7 -7.58 -0.42 5.97e-13 Blood protein levels; CESC cis rs12887734 0.524 rs12888002 chr14:104238647 T/C cg08213375 chr14:104286397 PPP1R13B 0.43 7.39 0.41 1.9e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs472402 0.623 rs8192135 chr5:6636757 T/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.46 -6.13 -0.35 3.2e-9 Response to amphetamines; CESC cis rs425277 0.958 rs262652 chr1:2090816 T/C cg04315214 chr1:2043799 PRKCZ -0.38 -5.31 -0.31 2.35e-7 Height; CESC cis rs10489525 0.599 rs2335724 chr1:115608444 T/C cg01522456 chr1:115632236 TSPAN2 0.45 5.45 0.32 1.14e-7 Autism; CESC cis rs4253772 0.513 rs9615345 chr22:46713631 C/T cg09491104 chr22:46646882 C22orf40 -0.58 -8.3 -0.45 5.42e-15 LDL cholesterol;Cholesterol, total; CESC cis rs8114671 0.562 rs6088636 chr20:33469746 C/T cg07148914 chr20:33460835 GGT7 0.44 5.89 0.34 1.17e-8 Height; CESC cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg22307029 chr19:49891270 CCDC155 0.51 5.97 0.34 7.52e-9 Multiple sclerosis; CESC cis rs2180341 0.960 rs6900074 chr6:127685893 A/G cg24812749 chr6:127587940 RNF146 1.05 15.12 0.68 1.2e-37 Breast cancer; CESC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg17724175 chr1:150552817 MCL1 0.42 6.36 0.36 8.76e-10 Urate levels; CESC cis rs3015497 0.554 rs8011039 chr14:51091267 C/T cg09863266 chr14:51125203 SAV1 -0.32 -5.03 -0.3 9.1e-7 Mean platelet volume; CESC cis rs2072499 0.932 rs2736613 chr1:156196016 T/C cg24450063 chr1:156163899 SLC25A44 0.96 15.65 0.69 1.58e-39 Testicular germ cell tumor; CESC cis rs2688608 0.592 rs7909802 chr10:75484186 G/C cg23231163 chr10:75533350 FUT11 -0.34 -5.28 -0.31 2.75e-7 Inflammatory bowel disease; CESC cis rs9486719 1.000 rs2092096 chr6:96870919 A/G cg06623918 chr6:96969491 KIAA0776 0.82 8.35 0.46 3.89e-15 Migraine;Coronary artery disease; CESC cis rs7666738 0.830 rs2865989 chr4:99067532 G/A cg03467027 chr4:99064603 C4orf37 0.48 5.96 0.34 7.81e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 0.765 rs2237276 chr6:167442115 C/T cg07741184 chr6:167504864 NA 0.36 6.49 0.37 4.31e-10 Crohn's disease; CESC cis rs9291683 0.595 rs35250962 chr4:10048271 C/T cg11266682 chr4:10021025 SLC2A9 0.68 13.29 0.63 3.1e-31 Bone mineral density; CESC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg22823121 chr1:150693482 HORMAD1 0.47 6.96 0.39 2.6e-11 Tonsillectomy; CESC cis rs7635838 0.819 rs904474 chr3:11524648 C/G cg00170343 chr3:11313890 ATG7 0.42 5.65 0.33 4.2e-8 HDL cholesterol; CESC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg24531977 chr5:56204891 C5orf35 -0.88 -10.98 -0.56 2.21e-23 Initial pursuit acceleration; CESC cis rs2742234 0.590 rs2505553 chr10:43681251 G/T cg15436174 chr10:43711423 RASGEF1A -0.49 -5.76 -0.33 2.3e-8 Hirschsprung disease; CESC trans rs7618501 0.699 rs9821675 chr3:49902544 A/G cg21659725 chr3:3221576 CRBN 0.59 8.21 0.45 9.53e-15 Intelligence (multi-trait analysis); CESC cis rs55823223 0.648 rs936394 chr17:73852008 C/A cg02397686 chr17:73851076 WBP2 0.59 7.47 0.42 1.16e-12 Psoriasis; CESC cis rs9300255 0.602 rs2682434 chr12:123694724 C/T cg19016782 chr12:123741754 C12orf65 -0.45 -6.51 -0.37 3.65e-10 Neutrophil percentage of white cells; CESC cis rs826838 1.000 rs1684416 chr12:39130301 G/A cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg02569458 chr12:86230093 RASSF9 0.52 7.79 0.43 1.55e-13 Major depressive disorder; CESC cis rs5758659 0.569 rs133294 chr22:42382805 C/T cg04733989 chr22:42467013 NAGA 0.47 6.14 0.35 2.93e-9 Cognitive function; CESC cis rs7937682 0.924 rs10891283 chr11:111527672 A/G cg22437258 chr11:111473054 SIK2 0.69 9.29 0.5 5.71e-18 Primary sclerosing cholangitis; CESC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg05255149 chr17:80675120 FN3KRP -0.46 -5.2 -0.3 3.93e-7 Breast cancer; CESC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg18758796 chr5:131593413 PDLIM4 0.41 5.65 0.33 4.12e-8 Breast cancer; CESC cis rs1568889 0.838 rs7933991 chr11:28059761 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.53 0.64 4.71e-32 Bipolar disorder; CESC cis rs2742234 0.590 rs2503848 chr10:43672785 G/A cg07801480 chr10:43725741 RASGEF1A 0.42 5.37 0.31 1.72e-7 Hirschsprung disease; CESC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg18240062 chr17:79603768 NPLOC4 -0.72 -10.28 -0.53 4.56e-21 Eye color traits; CESC trans rs57221529 0.664 rs72704802 chr5:554211 C/T cg25482853 chr8:67687455 SGK3 1.21 10.79 0.55 9.75e-23 Lung disease severity in cystic fibrosis; CESC cis rs1062177 1.000 rs2347596 chr5:151179199 T/C cg00977110 chr5:151150581 G3BP1 0.66 7.11 0.4 1.06e-11 Preschool internalizing problems; CESC cis rs3793683 1.000 rs3793683 chr10:134568387 G/T cg27286337 chr10:134555280 INPP5A -0.91 -14.24 -0.66 1.5e-34 Migraine; CESC cis rs7408868 1.000 rs4809029 chr19:15273248 A/C cg14696996 chr19:15285081 NOTCH3 1.11 11.32 0.57 1.67e-24 Pulse pressure; CESC cis rs2076222 1.000 rs2076350 chr1:209800341 C/T cg00257659 chr1:209800214 LAMB3 -0.87 -8.14 -0.45 1.6e-14 Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours); CESC cis rs1950626 0.833 rs2400963 chr14:101395706 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.79 10.83 0.55 7.22e-23 Pelvic organ prolapse (moderate/severe); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01764079 chr8:144718741 ZNF623 -0.45 -6.12 -0.35 3.34e-9 Gut microbiota (bacterial taxa); CESC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg22467129 chr15:76604101 ETFA -0.39 -6.0 -0.35 6.37e-9 Blood metabolite levels; CESC trans rs7178375 1.000 rs35162264 chr15:31200683 T/A cg04373760 chr16:53404718 NA 0.57 7.49 0.42 1e-12 Hypertriglyceridemia; CESC cis rs1371867 0.875 rs28595052 chr8:101327553 G/A cg11906718 chr8:101322791 RNF19A 0.54 6.89 0.39 4.05e-11 Atrioventricular conduction; CESC cis rs6963495 0.818 rs73192120 chr7:105171156 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.5 -0.32 9.1e-8 Bipolar disorder (body mass index interaction); CESC cis rs644799 0.965 rs2508713 chr11:95547927 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.61 0.38 2.07e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs727505 0.754 rs56012154 chr7:124781250 A/G cg23710748 chr7:124431027 NA -0.38 -6.2 -0.36 2.14e-9 Lewy body disease; CESC cis rs17039065 1.000 rs11736209 chr4:109394658 A/T cg16022748 chr4:109541635 LOC285456;RPL34 0.65 5.52 0.32 8.2e-8 Gut microbiome composition (summer); CESC cis rs250677 0.652 rs1422582 chr5:148436925 T/C cg18129178 chr5:148520854 ABLIM3 -0.54 -5.38 -0.31 1.6e-7 Breast cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07087156 chr2:228190257 NA -0.44 -6.34 -0.36 1.01e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs877282 0.945 rs877280 chr10:771599 C/T cg22713356 chr15:30763199 NA 1.26 12.69 0.61 3.79e-29 Uric acid levels; CESC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg09699651 chr6:150184138 LRP11 0.41 5.14 0.3 5.32e-7 Lung cancer; CESC cis rs2072732 0.687 rs10489588 chr1:2951834 C/T cg15211996 chr1:2936768 ACTRT2 0.33 5.94 0.34 8.91e-9 Plateletcrit; CESC cis rs9596863 1.000 rs9568940 chr13:54419251 C/A ch.13.53330881F chr13:54432880 NA 0.65 5.26 0.31 2.99e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs9300255 0.722 rs12304248 chr12:123810425 C/T cg19016782 chr12:123741754 C12orf65 0.44 6.02 0.35 5.91e-9 Neutrophil percentage of white cells; CESC trans rs17685 0.753 rs9691174 chr7:75790405 T/C cg19862616 chr7:65841803 NCRNA00174 0.84 12.03 0.59 6.77e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs17253792 0.659 rs34330219 chr14:56017375 G/A cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04775315 chr10:71168737 TACR2 0.61 6.95 0.39 2.82e-11 Gut microbiome composition (summer); CESC cis rs17102423 0.661 rs45604339 chr14:65543102 C/T cg11161011 chr14:65562177 MAX -0.49 -5.45 -0.32 1.14e-7 Obesity-related traits; CESC cis rs17345786 1.000 rs17345786 chr3:101318318 A/C cg12386194 chr3:101231763 SENP7 -0.57 -6.47 -0.37 4.8e-10 Colonoscopy-negative controls vs population controls; CESC cis rs4660261 0.526 rs2485997 chr1:44345841 G/C cg13606994 chr1:44402422 ARTN -0.37 -5.6 -0.33 5.47e-8 Intelligence (multi-trait analysis); CESC cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.52 0.46 1.18e-15 Hip circumference adjusted for BMI; CESC cis rs4466137 0.953 rs7735476 chr5:83015140 G/C cg16102102 chr5:83017553 HAPLN1 -0.51 -7.16 -0.4 8.14e-12 Prostate cancer; CESC trans rs5417 0.636 rs222851 chr17:7139238 G/A cg15655154 chr3:113604241 GRAMD1C 0.53 7.15 0.4 8.49e-12 Diastolic blood pressure; CESC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.43 -0.42 1.46e-12 Total body bone mineral density; CESC cis rs1538970 0.816 rs4633317 chr1:45985157 T/C cg03146154 chr1:46216737 IPP 0.48 5.47 0.32 1.03e-7 Platelet count; CESC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7692995 1.000 rs11930366 chr4:17960168 G/A cg08925142 chr4:18023851 LCORL -0.45 -5.13 -0.3 5.66e-7 Height; CESC cis rs7665939 0.932 rs10022377 chr4:190108803 C/T cg09826759 chr4:190284978 NA -0.65 -6.9 -0.39 3.72e-11 Amyotrophic lateral sclerosis; CESC cis rs72945132 0.882 rs57810426 chr11:70230030 G/A cg00319359 chr11:70116639 PPFIA1 0.73 7.1 0.4 1.11e-11 Coronary artery disease; CESC cis rs6775745 0.689 rs1406778 chr3:131750466 T/C cg12213930 chr3:131751605 CPNE4 0.47 5.17 0.3 4.61e-7 Neutrophil count; CESC cis rs2742234 0.590 rs2293020 chr10:43692887 A/G cg07801480 chr10:43725741 RASGEF1A -0.43 -5.6 -0.33 5.36e-8 Hirschsprung disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14047321 chr14:62523576 SYT16 -0.45 -6.17 -0.35 2.54e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06066128 chr3:47018377 CCDC12 -0.53 -6.74 -0.38 9.59e-11 Asthma; CESC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.46 5.88 0.34 1.26e-8 Tuberculosis; CESC trans rs1005277 0.579 rs176838 chr10:38371899 A/T cg17830980 chr10:43048298 ZNF37B 0.47 6.24 0.36 1.72e-9 Extrinsic epigenetic age acceleration; CESC cis rs763121 0.962 rs909564 chr22:39126508 A/G cg06544989 chr22:39130855 UNC84B 0.46 8.65 0.47 5.06e-16 Menopause (age at onset); CESC cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg25554036 chr4:6271136 WFS1 0.57 9.67 0.51 3.93e-19 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs3824867 0.920 rs7101772 chr11:47449378 A/G cg20307385 chr11:47447363 PSMC3 -0.47 -5.54 -0.32 7.3900000000000007e-08 Mean corpuscular hemoglobin; CESC trans rs7937682 0.961 rs4936682 chr11:111629743 T/G cg18187862 chr3:45730750 SACM1L -0.55 -6.08 -0.35 4.12e-9 Primary sclerosing cholangitis; CESC cis rs911555 0.723 rs4906324 chr14:103923099 A/G cg24130564 chr14:104152367 KLC1 0.5 6.6 0.38 2.27e-10 Intelligence (multi-trait analysis); CESC cis rs9486719 1.000 rs34236778 chr6:96884556 C/A cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs2658782 0.547 rs3133454 chr11:93059019 A/C cg15737290 chr11:93063684 CCDC67 0.55 7.61 0.42 4.71e-13 Pulmonary function decline; CESC cis rs1018836 0.892 rs1476428 chr8:91555603 G/T cg16814680 chr8:91681699 NA -0.61 -8.71 -0.47 3.26e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9929218 0.551 rs2296409 chr16:68713730 G/A cg02972257 chr16:68554789 NA -0.43 -5.26 -0.31 2.96e-7 Colorectal cancer; CESC cis rs7809950 1.000 rs17154104 chr7:107090698 C/T cg23024343 chr7:107201750 COG5 -0.38 -5.41 -0.32 1.41e-7 Coronary artery disease; CESC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg04944784 chr2:26401820 FAM59B 0.96 10.55 0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg07636037 chr3:49044803 WDR6 1.03 18.76 0.76 1.49e-50 Parkinson's disease; CESC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg16049864 chr8:95962084 TP53INP1 -0.71 -13.23 -0.63 5.18e-31 Type 2 diabetes; CESC cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.7 6.61 0.38 2.08e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 -0.45 -5.92 -0.34 1.01e-8 Tonsillectomy; CESC cis rs8014204 0.604 rs11625594 chr14:75389833 G/A cg26191576 chr14:75389716 RPS6KL1 -0.4 -5.59 -0.32 5.6e-8 Caffeine consumption; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24409649 chr12:31479318 FAM60A -0.46 -6.4 -0.37 7.12e-10 Asthma; CESC cis rs6432018 0.964 rs7565646 chr2:9728879 A/G cg23886495 chr2:9695866 ADAM17 0.44 5.18 0.3 4.5e-7 Heart rate variability traits; CESC cis rs2404602 0.684 rs1011083 chr15:77007527 C/T cg23625390 chr15:77176239 SCAPER -0.47 -6.52 -0.37 3.54e-10 Blood metabolite levels; CESC cis rs6800768 0.633 rs826375 chr3:24163964 A/G cg10674438 chr3:24145617 LOC152024 -0.46 -7.02 -0.4 1.83e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs599083 0.573 rs3018713 chr11:68390986 A/G cg20283391 chr11:68216788 NA -0.43 -5.25 -0.31 3.18e-7 Bone mineral density (spine); CESC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg08736216 chr1:53307985 ZYG11A 0.4 6.55 0.37 3.06e-10 Monocyte count; CESC cis rs7772486 0.817 rs9386145 chr6:146363519 A/T cg05347473 chr6:146136440 FBXO30 0.47 6.16 0.35 2.66e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg05863683 chr7:1912471 MAD1L1 0.43 6.57 0.37 2.61e-10 Bipolar disorder and schizophrenia; CESC cis rs7191439 0.858 rs11076702 chr16:88774569 A/C cg02389323 chr16:88786976 FAM38A 1.09 8.71 0.47 3.29e-16 Plateletcrit; CESC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg02038168 chr22:39784481 NA -0.61 -7.98 -0.44 4.55e-14 Intelligence (multi-trait analysis); CESC cis rs4523957 0.928 rs9905529 chr17:2177732 T/C cg16513277 chr17:2031491 SMG6 -0.59 -8.07 -0.44 2.41e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs17685 0.736 rs4732594 chr7:75753273 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.41 0.61 3.51e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.71 -7.39 -0.41 1.9e-12 Gut microbiome composition (summer); CESC cis rs7847628 0.765 rs10985024 chr9:123516812 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.5 5.97 0.34 7.78e-9 Birth weight; CESC cis rs2302729 0.860 rs6489375 chr12:2777768 A/G cg19945202 chr12:2788847 CACNA1C -0.41 -5.66 -0.33 3.92e-8 Sleep quality; CESC cis rs11785400 0.731 rs9720504 chr8:143725502 T/C cg10596483 chr8:143751796 JRK 0.42 5.36 0.31 1.77e-7 Schizophrenia; CESC cis rs597539 0.654 rs7107137 chr11:68623712 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.35 0.5 3.73e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs965469 1.000 rs6051732 chr20:3294182 G/A cg25506879 chr20:3388711 C20orf194 -0.57 -6.08 -0.35 4.19e-9 IFN-related cytopenia; CESC cis rs10242455 0.702 rs79878591 chr7:99082928 C/T cg18809830 chr7:99032528 PTCD1 -0.84 -5.59 -0.32 5.72e-8 Blood metabolite levels; CESC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.21 0.36 2.01e-9 Menopause (age at onset); CESC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg15782153 chr7:917662 C7orf20 -0.49 -5.43 -0.32 1.25e-7 Cerebrospinal P-tau181p levels; CESC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg00129232 chr17:37814104 STARD3 0.55 7.29 0.41 3.49e-12 Glomerular filtration rate (creatinine); CESC cis rs5753618 0.583 rs5753631 chr22:31863022 A/C cg00478049 chr22:31556069 RNF185 -0.43 -5.15 -0.3 5.2e-7 Colorectal cancer; CESC cis rs1670533 0.746 rs688008 chr4:1082829 T/C cg04106633 chr4:1044584 NA 0.4 5.1 0.3 6.33e-7 Recombination rate (females); CESC cis rs3820068 0.705 rs927206 chr1:15893338 C/T cg18192808 chr1:15853278 DNAJC16 0.46 5.52 0.32 7.92e-8 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04245873 chr15:63796130 USP3 -0.67 -8.21 -0.45 9.48e-15 Gut microbiome composition (summer); CESC cis rs6866344 0.697 rs11742808 chr5:178131658 G/A cg03877680 chr5:178157825 ZNF354A 0.75 8.5 0.46 1.38e-15 Neutrophil percentage of white cells; CESC trans rs4942242 0.763 rs7326281 chr13:44233186 G/A cg19169023 chr15:41853346 TYRO3 -0.65 -8.88 -0.48 1.06e-16 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3820928 0.874 rs13413235 chr2:227893863 C/T cg11843606 chr2:227700838 RHBDD1 -0.48 -6.37 -0.36 8.53e-10 Pulmonary function; CESC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg19717773 chr7:2847554 GNA12 -0.56 -7.8 -0.43 1.42e-13 Height; CESC cis rs3820928 1.000 rs12615988 chr2:227769000 A/G cg05526886 chr2:227700861 RHBDD1 -0.42 -5.54 -0.32 7.26e-8 Pulmonary function; CESC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg04267008 chr7:1944627 MAD1L1 -0.53 -6.51 -0.37 3.7e-10 Bipolar disorder and schizophrenia; CESC cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -5.76 -0.33 2.3e-8 Axial length; CESC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg01448562 chr3:133502909 NA -0.42 -5.95 -0.34 8.32e-9 Iron status biomarkers; CESC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg04248312 chr19:17393744 ANKLE1 -0.92 -14.85 -0.67 1.01e-36 Systemic lupus erythematosus; CESC cis rs2273669 0.667 rs76267985 chr6:109326183 A/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.31 -0.31 2.36e-7 Prostate cancer; CESC cis rs9287719 0.934 rs4629131 chr2:10744159 C/T cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs1642645 0.872 rs4660586 chr1:42407229 C/T cg16685388 chr1:42384056 HIVEP3 0.37 5.04 0.3 8.77e-7 Left ventricular obstructive tract defect (maternal effect); CESC cis rs9549367 0.789 rs12584813 chr13:113895443 C/G cg00898013 chr13:113819073 PROZ -0.5 -6.91 -0.39 3.69e-11 Platelet distribution width; CESC trans rs11098499 0.562 rs13101722 chr4:120555975 C/A cg25214090 chr10:38739885 LOC399744 -0.52 -7.39 -0.41 1.88e-12 Corneal astigmatism; CESC cis rs6460942 1.000 rs62448568 chr7:12407445 A/G cg02935154 chr7:12443704 VWDE -0.57 -5.89 -0.34 1.16e-8 Coronary artery disease; CESC cis rs72781680 0.898 rs56315094 chr2:23941952 T/C cg20701182 chr2:24300061 SF3B14 0.69 6.2 0.36 2.18e-9 Lymphocyte counts; CESC cis rs8092503 1.000 rs12968302 chr18:52478970 A/G cg12377874 chr18:52495404 RAB27B 0.38 6.27 0.36 1.46e-9 Childhood body mass index; CESC cis rs1451375 0.617 rs896307 chr7:50569060 T/C cg14593290 chr7:50529359 DDC -0.52 -6.56 -0.37 2.82e-10 Malaria; CESC cis rs9863 0.828 rs71458830 chr12:124476561 C/T cg17562584 chr12:124393655 DNAH10 0.3 5.21 0.3 3.88e-7 White blood cell count; CESC cis rs6460942 0.591 rs4721082 chr7:12341804 A/G cg20607287 chr7:12443886 VWDE -0.58 -6.29 -0.36 1.28e-9 Coronary artery disease; CESC trans rs1945213 0.694 rs7131381 chr11:55858158 T/G cg15704280 chr7:45808275 SEPT13 0.76 7.34 0.41 2.57e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs870825 0.616 rs6825561 chr4:185615532 A/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs9796 0.689 rs8032195 chr15:41448790 G/A cg12426344 chr15:41135900 SPINT1 -0.24 -5.36 -0.31 1.79e-7 Menopause (age at onset); CESC cis rs9287719 0.967 rs4613248 chr2:10744051 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 2.97e-8 Mean platelet volume; CESC cis rs7666738 0.830 rs7672901 chr4:98938781 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.4 0.46 2.75e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs7618501 0.521 rs11709573 chr3:49956628 C/T cg24308560 chr3:49941425 MST1R -0.58 -8.38 -0.46 3.15e-15 Intelligence (multi-trait analysis); CESC cis rs8070624 0.574 rs9914127 chr17:17875836 A/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.53 6.69 0.38 1.3100000000000001e-10 Total body bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27576415 chr15:41709087 RTF1 -0.53 -7.83 -0.43 1.14e-13 Gambling; CESC cis rs7116495 1.000 rs7937582 chr11:71744613 C/T cg26138937 chr11:71823887 C11orf51 -0.83 -6.72 -0.38 1.14e-10 Severe influenza A (H1N1) infection; CESC cis rs79057730 0.599 rs34411410 chr7:811721 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.91 7.84 0.43 1.1e-13 Initial pursuit acceleration; CESC cis rs1595825 0.891 rs74965164 chr2:198499162 C/T cg10820045 chr2:198174542 NA 0.41 5.14 0.3 5.33e-7 Ulcerative colitis; CESC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg18099408 chr3:52552593 STAB1 0.34 6.08 0.35 4.06e-9 Electroencephalogram traits; CESC cis rs933688 1.000 rs1363839 chr5:90671274 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 12.55 0.61 1.16e-28 Smoking behavior; CESC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.77 -0.33 2.2e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg11764359 chr7:65958608 NA 0.89 13.18 0.63 7.3e-31 Aortic root size; CESC cis rs4969178 0.965 rs3744217 chr17:76400258 G/A cg05887092 chr17:76393375 PGS1 0.58 9.26 0.49 7e-18 HDL cholesterol levels; CESC cis rs6089584 0.566 rs11699442 chr20:60623268 A/G cg06108461 chr20:60628389 TAF4 -0.61 -8.04 -0.44 2.95e-14 Body mass index; CESC cis rs116095464 0.558 rs9688136 chr5:229348 T/C cg10591111 chr5:226296 SDHA -0.54 -6.65 -0.38 1.72e-10 Breast cancer; CESC cis rs35110281 0.807 rs2838325 chr21:45014284 A/T cg21573476 chr21:45109991 RRP1B 0.41 6.02 0.35 5.92e-9 Mean corpuscular volume; CESC cis rs9303401 0.646 rs7342863 chr17:57227010 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.55 7.28 0.41 3.78e-12 Cognitive test performance; CESC cis rs7089973 0.525 rs11196945 chr10:116600424 G/A cg03647239 chr10:116582469 FAM160B1 0.43 5.35 0.31 1.94e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs67478160 0.595 rs1475007 chr14:104297147 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.35 0.54 2.54e-21 Schizophrenia; CESC cis rs4835473 0.897 rs35598237 chr4:144657114 C/T cg25736465 chr4:144833511 NA -0.33 -5.16 -0.3 4.78e-7 Immature fraction of reticulocytes; CESC cis rs9611519 0.567 rs8141730 chr22:41473061 A/G cg03806693 chr22:41940476 POLR3H -0.43 -5.22 -0.31 3.67e-7 Neuroticism; CESC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg24675658 chr1:53192096 ZYG11B -0.66 -9.3 -0.5 5.42e-18 Monocyte count; CESC cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg18016565 chr1:150552671 MCL1 -0.42 -6.98 -0.39 2.33e-11 Tonsillectomy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11844697 chr17:80935769 B3GNTL1 0.41 6.3 0.36 1.27e-9 Gambling; CESC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg27266027 chr21:40555129 PSMG1 0.44 5.2 0.3 4.04e-7 Cognitive function; CESC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg04553112 chr3:125709451 NA -0.55 -5.82 -0.34 1.71e-8 Blood pressure (smoking interaction); CESC cis rs9815354 0.812 rs17215498 chr3:41829679 G/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs72781680 1.000 rs12616899 chr2:24165235 A/G cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14492347 chr15:85292323 ZNF592 -0.47 -6.73 -0.38 1.05e-10 Gambling; CESC cis rs7582720 1.000 rs72932588 chr2:203883193 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg20271620 chr17:80763330 TBCD 0.45 5.28 0.31 2.71e-7 Breast cancer; CESC cis rs6499255 0.951 rs3743673 chr16:69711311 A/T cg15192750 chr16:69999425 NA 0.49 5.65 0.33 4.18e-8 IgE levels; CESC cis rs1355223 0.583 rs2915179 chr11:34871943 C/T cg11058730 chr11:34937778 PDHX;APIP 0.83 12.62 0.61 6.47e-29 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2735413 0.881 rs12927515 chr16:78080141 T/G cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.13e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg08027265 chr7:2291960 NA -0.37 -5.53 -0.32 7.61e-8 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.761 rs1456210 chr4:98645932 T/G cg03467027 chr4:99064603 C4orf37 0.42 5.26 0.31 2.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg11494091 chr17:61959527 GH2 0.72 12.39 0.61 4.12e-28 Prudent dietary pattern; CESC cis rs2072732 0.861 rs6661908 chr1:2950334 C/T cg03976712 chr1:2946727 NA 0.34 5.77 0.33 2.22e-8 Plateletcrit; CESC cis rs7937682 1.000 rs11608122 chr11:111535105 C/T cg22437258 chr11:111473054 SIK2 -0.68 -7.96 -0.44 5.09e-14 Primary sclerosing cholangitis; CESC cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 2e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.77 -12.33 -0.6 6.78e-28 Personality dimensions; CESC cis rs6752107 0.967 rs3792111 chr2:234179690 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.39 5.81 0.34 1.82e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs2274273 0.870 rs10147434 chr14:55674847 C/T cg04306507 chr14:55594613 LGALS3 0.3 5.95 0.34 8.35e-9 Protein biomarker; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00837838 chr15:45003774 B2M 0.57 6.17 0.35 2.56e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02724903 chr13:114260339 TFDP1 0.48 6.7 0.38 1.24e-10 Fibrinogen levels; CESC cis rs868036 0.522 rs3784711 chr15:68072527 C/T cg08079166 chr15:68083412 MAP2K5 -0.43 -6.87 -0.39 4.69e-11 Restless legs syndrome; CESC cis rs10883723 0.773 rs7917402 chr10:104246690 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.14 0.3 5.44e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs372883 0.600 rs1153276 chr21:30661694 T/C cg08807101 chr21:30365312 RNF160 -0.51 -5.91 -0.34 1.03e-8 Pancreatic cancer; CESC cis rs9399135 0.967 rs6915770 chr6:135369214 G/A cg22676075 chr6:135203613 NA 0.52 7.3 0.41 3.39e-12 Red blood cell count; CESC cis rs7917772 0.503 rs7096072 chr10:104299976 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.33 0.41 2.81e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9905704 0.627 rs1267543 chr17:56656624 A/G cg12560992 chr17:57184187 TRIM37 -0.61 -6.3 -0.36 1.24e-9 Testicular germ cell tumor; CESC cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 5.52 0.32 8e-8 Colorectal cancer; CESC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg04287289 chr16:89883240 FANCA -0.48 -5.89 -0.34 1.16e-8 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12457986 chr21:27107982 ATP5J;GABPA -0.44 -6.02 -0.35 5.69e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21364231 chr7:152161058 LOC100128822 0.59 6.34 0.36 9.66e-10 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs55833259 chr5:286728 G/A cg22496380 chr5:211416 CCDC127 -0.99 -10.19 -0.53 8.71e-21 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19575813 chr18:46476937 SMAD7 0.56 6.34 0.36 9.58e-10 Gut microbiome composition (summer); CESC cis rs7296418 0.699 rs11057219 chr12:123750073 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.12 -0.3 6.01e-7 Platelet count; CESC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg00129232 chr17:37814104 STARD3 -0.59 -7.88 -0.44 8.59e-14 Glomerular filtration rate (creatinine); CESC cis rs977987 0.806 rs4888411 chr16:75443183 T/A cg03315344 chr16:75512273 CHST6 0.41 5.86 0.34 1.35e-8 Dupuytren's disease; CESC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg06221963 chr1:154839813 KCNN3 -0.71 -12.45 -0.61 2.58e-28 Prostate cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24797830 chr7:99686956 COPS6 -0.48 -6.59 -0.38 2.42e-10 Asthma; CESC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg26119090 chr2:26468346 HADHA;HADHB 1.08 11.71 0.58 8.24e-26 Gut microbiome composition (summer); CESC cis rs6732160 0.564 rs2043096 chr2:73375723 T/C cg01422370 chr2:73384389 NA 0.57 9.11 0.49 2.01e-17 Intelligence (multi-trait analysis); CESC cis rs3617 0.625 rs56019197 chr3:52874753 T/C cg11645453 chr3:52864694 ITIH4 -0.25 -5.07 -0.3 7.43e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs4290604 0.665 rs6761002 chr2:238038873 T/C cg23555395 chr2:238036564 NA -0.62 -5.71 -0.33 3.06e-8 Asthma; CESC cis rs1538970 0.924 rs11211108 chr1:45891152 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.46 0.32 1.11e-7 Platelet count; CESC trans rs12310956 0.532 rs1589902 chr12:33989289 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.64 0.38 1.82e-10 Morning vs. evening chronotype; CESC cis rs11098499 0.954 rs10024844 chr4:120311528 A/G cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs7223966 1.000 rs7216798 chr17:61740963 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.42 0.41 1.55e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg08888203 chr3:10149979 C3orf24 0.49 6.24 0.36 1.68e-9 Alzheimer's disease; CESC cis rs921968 0.643 rs524902 chr2:219433357 A/C cg02176678 chr2:219576539 TTLL4 0.41 7.03 0.4 1.72e-11 Mean corpuscular hemoglobin concentration; CESC cis rs6499255 0.951 rs10500551 chr16:69666970 C/T cg15192750 chr16:69999425 NA 0.44 5.24 0.31 3.32e-7 IgE levels; CESC cis rs2230307 0.536 rs7530361 chr1:100462860 T/C cg24955406 chr1:100503596 HIAT1 0.53 5.39 0.31 1.56e-7 Carotid intima media thickness; CESC cis rs9583531 0.689 rs2165418 chr13:111379365 G/T cg15841412 chr13:111365552 ING1 -0.42 -5.16 -0.3 4.8e-7 Coronary artery disease; CESC cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg11890956 chr21:40555474 PSMG1 0.68 9.48 0.5 1.48e-18 Cognitive function; CESC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg11247378 chr22:39784982 NA -0.63 -9.17 -0.49 1.32e-17 Intelligence (multi-trait analysis); CESC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.84 0.34 1.48e-8 Tonsillectomy; CESC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg06634786 chr22:41940651 POLR3H -0.7 -7.4 -0.41 1.85e-12 Vitiligo; CESC trans rs1814175 0.692 rs1851873 chr11:49937767 A/G cg15704280 chr7:45808275 SEPT13 -0.82 -11.35 -0.57 1.34e-24 Height; CESC cis rs2262909 0.962 rs425781 chr19:22229306 A/G cg11619707 chr19:22235551 ZNF257 -0.32 -5.26 -0.31 2.94e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs77106637 1.000 rs3862791 chr11:72501002 C/T cg03713592 chr11:72463424 ARAP1 1.23 11.1 0.56 9.02e-24 Type 2 diabetes; CESC cis rs2180341 0.618 rs12199451 chr6:127597780 C/G cg27446573 chr6:127587934 RNF146 0.59 7.77 0.43 1.71e-13 Breast cancer; CESC cis rs1707322 1.000 rs7517560 chr1:46425943 A/G cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16285902 chr11:32605422 EIF3M 0.63 7.26 0.41 4.34e-12 Gut microbiome composition (summer); CESC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.05e-8 Lung cancer; CESC cis rs863345 0.967 rs7527623 chr1:158469859 G/A cg12129480 chr1:158549410 OR10X1 -0.31 -6.19 -0.36 2.34e-9 Pneumococcal bacteremia; CESC cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.79 8.08 0.44 2.27e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11203032 0.831 rs10788635 chr10:90927063 A/G cg16672925 chr10:90967113 CH25H 0.45 5.13 0.3 5.55e-7 Heart failure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25001845 chr14:75201709 FCF1 0.45 6.25 0.36 1.6e-9 Fibrinogen levels; CESC trans rs61931739 0.500 rs34287388 chr12:34444626 C/A cg13010199 chr12:38710504 ALG10B 0.48 6.28 0.36 1.38e-9 Morning vs. evening chronotype; CESC cis rs11098499 0.575 rs907204 chr4:120238654 G/A cg09307838 chr4:120376055 NA 0.79 10.77 0.55 1.17e-22 Corneal astigmatism; CESC cis rs12500482 0.935 rs2239736 chr4:2438929 T/C cg08330972 chr4:2403930 ZFYVE28 -0.35 -5.21 -0.3 3.85e-7 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05508062 chr3:62110348 ID2B;PTPRG -0.62 -7.1 -0.4 1.13e-11 Gut microbiome composition (summer); CESC cis rs9470366 1.000 rs9470366 chr6:36625562 C/T cg08179530 chr6:36648295 CDKN1A 0.47 5.69 0.33 3.33e-8 QRS duration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11725182 chr1:5968678 NPHP4 0.51 6.58 0.37 2.57e-10 Fibrinogen levels; CESC cis rs727505 0.954 rs17327014 chr7:124709349 C/T cg23710748 chr7:124431027 NA -0.39 -6.1 -0.35 3.77e-9 Lewy body disease; CESC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -7.44 -0.42 1.37e-12 Bipolar disorder and schizophrenia; CESC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg09658497 chr7:2847517 GNA12 -0.38 -5.33 -0.31 2.15e-7 Height; CESC cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg17644776 chr2:200775616 C2orf69 0.56 6.82 0.39 5.99e-11 Osteoporosis; CESC cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.39 -6.53 -0.37 3.3e-10 Hemoglobin concentration; CESC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.29e-8 Developmental language disorder (linguistic errors); CESC trans rs11098499 0.866 rs9991221 chr4:120292107 G/C cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg03806693 chr22:41940476 POLR3H -1.15 -16.09 -0.7 4.08e-41 Vitiligo; CESC cis rs1020064 0.945 rs1030878 chr2:105910598 T/G cg02079111 chr2:105885981 TGFBRAP1 0.49 6.38 0.37 7.65e-10 AIDS; CESC cis rs7605827 0.930 rs6431712 chr2:15691292 C/T cg19274914 chr2:15703543 NA 0.37 6.67 0.38 1.5e-10 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15798163 chr13:113933520 NA -0.64 -7.49 -0.42 1.03e-12 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04667467 chr16:90089176 GAS8 -0.47 -6.13 -0.35 3.15e-9 Ulcerative colitis; CESC cis rs2996428 0.667 rs61768933 chr1:3766587 G/A cg13057898 chr1:3703894 LRRC47 0.45 6.14 0.35 2.98e-9 Red cell distribution width; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07721005 chr5:87564621 TMEM161B -0.45 -6.18 -0.35 2.43e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg21285383 chr16:89894308 SPIRE2 0.3 5.28 0.31 2.65e-7 Vitiligo; CESC cis rs9658691 0.607 rs12411483 chr10:90780910 G/T cg03111039 chr10:90751583 FAS;ACTA2 -0.58 -5.25 -0.31 3.08e-7 Mosquito bite size; CESC cis rs9859260 0.614 rs493661 chr3:195786489 T/A cg12923728 chr3:195709715 SDHAP1 0.53 6.86 0.39 4.83e-11 Mean corpuscular volume; CESC cis rs2979489 0.699 rs62508370 chr8:30417026 G/A cg26383811 chr8:30366931 RBPMS -0.74 -8.84 -0.48 1.39e-16 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg19717773 chr7:2847554 GNA12 -0.53 -8.32 -0.45 4.85e-15 Height; CESC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.92 0.52 6.18e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10949834 0.529 rs7785826 chr7:73548785 C/A cg07137043 chr7:73588983 EIF4H -0.65 -6.99 -0.39 2.23e-11 Verbal memory performance (residualized delayed recall change); CESC cis rs2066819 1.000 rs75754909 chr12:56726349 A/G cg26734620 chr12:56694298 CS 0.98 5.95 0.34 8.45e-9 Psoriasis vulgaris; CESC cis rs1185460 0.967 rs1784461 chr11:118937985 G/A cg23280166 chr11:118938394 VPS11 0.58 8.16 0.45 1.4e-14 Coronary artery disease; CESC cis rs1949733 0.701 rs4696828 chr4:8455604 G/A cg11789530 chr4:8429930 ACOX3 -0.76 -10.91 -0.56 3.99e-23 Response to antineoplastic agents; CESC cis rs12476592 0.602 rs10865339 chr2:63811884 G/T cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17461271 chr1:172717683 NA -0.49 -6.59 -0.38 2.34e-10 Gut microbiota (bacterial taxa); CESC cis rs116095464 0.558 rs13357299 chr5:242211 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.48 5.12 0.3 5.84e-7 Breast cancer; CESC cis rs6831352 0.918 rs29001231 chr4:100046680 T/C cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs7246657 0.882 rs13345148 chr19:37819631 A/G cg23950597 chr19:37808831 NA -0.55 -6.06 -0.35 4.54e-9 Coronary artery calcification; CESC cis rs2243480 1.000 rs9769882 chr7:65642925 T/C cg13147721 chr7:65941812 NA 0.97 9.16 0.49 1.47e-17 Diabetic kidney disease; CESC cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg08917208 chr2:24149416 ATAD2B -0.56 -5.26 -0.31 2.92e-7 Lymphocyte counts; CESC cis rs644799 0.544 rs1150360 chr11:95512060 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.49 6.47 0.37 4.68e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.11 19.58 0.77 2.06e-53 Height; CESC cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg18016565 chr1:150552671 MCL1 -0.39 -6.47 -0.37 4.78e-10 Tonsillectomy; CESC cis rs8053891 0.615 rs2287997 chr16:72140553 G/A cg16558253 chr16:72132732 DHX38 -0.52 -6.2 -0.36 2.1e-9 Coronary artery disease; CESC cis rs6963495 0.818 rs73192145 chr7:105203628 A/C cg13798780 chr7:105162888 PUS7 0.77 7.63 0.42 4.27e-13 Bipolar disorder (body mass index interaction); CESC cis rs2204008 0.837 rs11180549 chr12:38236950 A/G cg26384229 chr12:38710491 ALG10B 0.73 10.35 0.54 2.55e-21 Bladder cancer; CESC cis rs9916302 0.861 rs11658219 chr17:37709782 G/A cg00129232 chr17:37814104 STARD3 -0.59 -7.79 -0.43 1.49e-13 Glomerular filtration rate (creatinine); CESC cis rs7520050 0.966 rs2275426 chr1:46487552 G/A cg24296786 chr1:45957014 TESK2 0.44 5.5 0.32 8.98e-8 Red blood cell count;Reticulocyte count; CESC cis rs2070997 0.607 rs9919036 chr9:133684844 A/G cg11464064 chr9:133710261 ABL1 0.57 6.36 0.36 8.71e-10 Response to amphetamines; CESC cis rs9527 0.590 rs11191553 chr10:104851396 G/T cg04362960 chr10:104952993 NT5C2 0.44 5.6 0.33 5.49e-8 Arsenic metabolism; CESC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.49 0.32 9.47e-8 Bipolar disorder; CESC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 10.14 0.53 1.26e-20 Platelet count; CESC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg25072359 chr17:41440525 NA 0.44 6.04 0.35 5.21e-9 Menopause (age at onset); CESC cis rs66731853 0.769 rs476582 chr1:20894450 A/G cg04087271 chr1:20915334 CDA -0.48 -6.91 -0.39 3.52e-11 Mean corpuscular volume; CESC cis rs17655565 0.581 rs73093302 chr12:52763203 A/G cg00777198 chr12:52828273 KRT75 0.35 5.07 0.3 7.59e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs3008870 1.000 rs3008870 chr1:67418027 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg00409905 chr10:38381863 ZNF37A -0.51 -6.8 -0.39 6.98e-11 Extrinsic epigenetic age acceleration; CESC cis rs11864453 0.762 rs6416742 chr16:72149061 C/T cg01557791 chr16:72042693 DHODH -0.53 -7.1 -0.4 1.17e-11 Fibrinogen levels; CESC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg16680214 chr1:154839983 KCNN3 -0.44 -6.69 -0.38 1.28e-10 Prostate cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15929228 chr2:240323491 HDAC4 -0.47 -6.2 -0.36 2.19e-9 Ulcerative colitis; CESC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs66561647 0.661 rs7835090 chr8:128940177 A/C cg05480350 chr8:128972681 MIR1205;PVT1 0.38 5.18 0.3 4.33e-7 Hemoglobin concentration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01928910 chr1:31194314 MATN1 0.39 6.04 0.35 5.3e-9 Fibrinogen levels; CESC cis rs17539620 0.624 rs62432746 chr6:154838986 A/G cg17771515 chr6:154831774 CNKSR3 0.59 5.82 0.34 1.69e-8 Lipoprotein (a) levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04562739 chr20:5107446 CDS2;PCNA -0.45 -6.05 -0.35 5e-9 Asthma; CESC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg21724239 chr8:58056113 NA 0.59 5.69 0.33 3.3e-8 Developmental language disorder (linguistic errors); CESC cis rs11828289 0.660 rs79045664 chr11:23238737 G/A cg20040320 chr11:23191996 NA -0.7 -5.92 -0.34 9.9e-9 Cancer; CESC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs7116495 1.000 rs2250866 chr11:71804513 A/G cg26138937 chr11:71823887 C11orf51 -0.65 -5.19 -0.3 4.25e-7 Severe influenza A (H1N1) infection; CESC cis rs9583531 0.657 rs7318291 chr13:111352460 C/T cg24331049 chr13:111365604 ING1 -0.76 -10.57 -0.54 5.01e-22 Coronary artery disease; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg13517516 chr9:20684768 KIAA1797 0.48 5.99 0.35 6.71e-9 Retinol levels; CESC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg22535103 chr8:58192502 C8orf71 -0.9 -9.01 -0.48 4.26e-17 Developmental language disorder (linguistic errors); CESC cis rs1808579 0.935 rs1140458 chr18:21119777 G/A cg14672496 chr18:21087552 C18orf8 0.37 5.68 0.33 3.47e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25320668 chr1:205196970 TMCC2 -0.44 -6.08 -0.35 4.26e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11247915 0.583 rs34058882 chr1:26659794 C/T cg04990556 chr1:26633338 UBXN11 -0.56 -6.3 -0.36 1.2e-9 Obesity-related traits; CESC cis rs17376456 0.877 rs7736620 chr5:93305762 C/T cg21475434 chr5:93447410 FAM172A 0.75 6.78 0.38 7.96e-11 Diabetic retinopathy; CESC cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg23711669 chr6:146136114 FBXO30 -1.05 -14.96 -0.68 4.26e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs10883723 0.810 rs10883729 chr10:104273943 A/G cg22532475 chr10:104410764 TRIM8 -0.35 -5.9 -0.34 1.13e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7662987 0.517 rs2602845 chr4:100023944 T/C cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.21e-14 Smoking initiation; CESC cis rs2235544 0.579 rs1537321 chr1:54482236 C/A cg25741118 chr1:54482237 LDLRAD1 -0.23 -5.99 -0.35 6.92e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs6088590 0.550 rs12624640 chr20:32952125 G/A cg06115741 chr20:33292138 TP53INP2 0.44 5.23 0.31 3.38e-7 Coronary artery disease; CESC cis rs10102274 1.000 rs7823529 chr8:91661083 C/T cg16814680 chr8:91681699 NA -0.8 -5.4 -0.31 1.47e-7 Cerebrospinal fluid clusterin levels; CESC cis rs9658691 0.607 rs9325604 chr10:90775756 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.62 -5.41 -0.32 1.43e-7 Mosquito bite size; CESC cis rs11264213 0.901 rs72661613 chr1:36364781 A/G cg27506609 chr1:36549197 TEKT2 0.68 5.63 0.33 4.5e-8 Schizophrenia; CESC cis rs4692589 0.606 rs34752946 chr4:170951738 G/T cg19918862 chr4:170955249 NA 0.45 5.62 0.33 4.79e-8 Anxiety disorder; CESC cis rs977987 0.843 rs12927562 chr16:75482860 G/A cg03315344 chr16:75512273 CHST6 0.42 6.0 0.35 6.43e-9 Dupuytren's disease; CESC cis rs9894429 0.789 rs7219915 chr17:79591813 C/T cg18240062 chr17:79603768 NPLOC4 0.9 13.2 0.63 6.66e-31 Eye color traits; CESC cis rs1670533 0.932 rs13106586 chr4:1054182 G/A cg04106633 chr4:1044584 NA 0.42 5.34 0.31 2.04e-7 Recombination rate (females); CESC cis rs1797885 0.524 rs2596823 chr3:12608345 A/G cg26432171 chr3:12704882 RAF1 -0.46 -5.94 -0.34 8.85e-9 Immature fraction of reticulocytes; CESC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg18490616 chr2:88469792 THNSL2 -0.5 -7.41 -0.41 1.66e-12 Response to metformin (IC50); CESC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg22549504 chr19:17448937 GTPBP3 0.5 5.56 0.32 6.74e-8 Systemic lupus erythematosus; CESC cis rs644799 1.000 rs596277 chr11:95566886 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.68 8.6 0.47 6.86e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2070997 0.651 rs35218356 chr9:133669521 T/C cg11464064 chr9:133710261 ABL1 0.57 6.7 0.38 1.24e-10 Response to amphetamines; CESC cis rs3820068 0.581 rs111699992 chr1:15927158 G/A cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs7000551 0.715 rs1530874 chr8:22347777 G/C cg12081754 chr8:22256438 SLC39A14 0.4 5.24 0.31 3.32e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg05332525 chr7:65337924 VKORC1L1 0.52 6.41 0.37 6.6e-10 Aortic root size; CESC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg10150615 chr22:24372951 LOC391322 -0.57 -7.82 -0.43 1.28e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07923666 chr12:49932857 KCNH3 0.62 7.43 0.42 1.48e-12 Gut microbiome composition (summer); CESC cis rs1801251 1.000 rs283484 chr2:233646505 A/G cg25237894 chr2:233734115 C2orf82 0.46 8.08 0.44 2.3e-14 Coronary artery disease; CESC cis rs2880765 0.566 rs55899824 chr15:86004091 C/T cg10818794 chr15:86012489 AKAP13 -0.36 -5.04 -0.3 8.5e-7 Coronary artery disease; CESC cis rs17539620 0.624 rs62432738 chr6:154835674 T/C cg17771515 chr6:154831774 CNKSR3 0.58 5.81 0.34 1.83e-8 Lipoprotein (a) levels; CESC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg22535103 chr8:58192502 C8orf71 -1.06 -13.36 -0.63 1.82e-31 Developmental language disorder (linguistic errors); CESC cis rs9911578 1.000 rs368186 chr17:56736659 A/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC cis rs4243830 0.850 rs4908558 chr1:6584101 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -9.22 -0.49 9.6e-18 Body mass index; CESC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg18402987 chr7:1209562 NA 0.64 6.48 0.37 4.58e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg12503243 chr14:45553114 PRPF39 0.42 6.19 0.36 2.31e-9 Positive affect; CESC cis rs9399135 0.935 rs949547 chr6:135343499 C/G cg24558204 chr6:135376177 HBS1L 0.52 7.29 0.41 3.48e-12 Red blood cell count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21587861 chr12:32260103 BICD1 0.49 6.18 0.35 2.34e-9 Gut microbiota (bacterial taxa); CESC cis rs7949030 0.588 rs2428548 chr11:62311462 A/G cg11742103 chr11:62369870 EML3;MTA2 0.57 8.63 0.47 5.87e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs12136530 0.625 rs4911992 chr1:19750486 T/A cg01832549 chr1:19774989 CAPZB -0.5 -6.87 -0.39 4.58e-11 Lead levels in blood; CESC cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.16 0.3 4.84e-7 Hip circumference adjusted for BMI; CESC cis rs1620921 0.505 rs1344731 chr6:161205037 G/A cg01280913 chr6:161186852 NA -0.35 -5.17 -0.3 4.72e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg22467129 chr15:76604101 ETFA -0.38 -5.77 -0.33 2.24e-8 Blood metabolite levels; CESC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg13012494 chr21:47604986 C21orf56 0.44 5.8 0.34 1.84e-8 Testicular germ cell tumor; CESC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg08859206 chr1:53392774 SCP2 0.53 7.09 0.4 1.19e-11 Monocyte count; CESC cis rs2228479 0.850 rs2238527 chr16:89840708 C/A cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg03060546 chr3:49711283 APEH 0.5 5.97 0.34 7.77e-9 Parkinson's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12994003 chr1:225616475 LBR 0.44 6.01 0.35 6.13e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6429082 0.818 rs291391 chr1:235649955 A/G cg26050004 chr1:235667680 B3GALNT2 0.63 7.78 0.43 1.63e-13 Adiposity; CESC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.39 5.25 0.31 3.16e-7 Bipolar disorder; CESC cis rs4713675 0.565 rs4713671 chr6:33699899 A/G cg14003231 chr6:33640908 ITPR3 0.3 5.34 0.31 1.95e-7 Plateletcrit; CESC cis rs854765 0.583 rs4925125 chr17:17794444 T/C cg09796270 chr17:17721594 SREBF1 -0.4 -5.6 -0.33 5.34e-8 Total body bone mineral density; CESC cis rs16895831 0.519 rs12196856 chr6:42554187 T/A cg10605015 chr6:42532144 UBR2 -0.5 -5.52 -0.32 7.87e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24531794 chr11:31531233 ELP4;IMMP1L 0.47 6.28 0.36 1.41e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1799949 0.864 rs60309406 chr17:41435665 C/T cg25072359 chr17:41440525 NA 0.46 6.23 0.36 1.87e-9 Menopause (age at onset); CESC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg26939375 chr7:64535504 NA 0.75 10.38 0.54 2.1e-21 Aortic root size; CESC trans rs9329221 0.935 rs3750310 chr8:10283426 G/A cg15556689 chr8:8085844 FLJ10661 -0.57 -6.49 -0.37 4.28e-10 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06128920 chr1:1447374 ATAD3A 0.62 7.4 0.41 1.83e-12 Gut microbiome composition (summer); CESC cis rs2637266 0.783 rs860165 chr10:78492807 A/G cg18941641 chr10:78392320 NA 0.44 8.54 0.46 1.06e-15 Pulmonary function; CESC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg16049864 chr8:95962084 TP53INP1 -0.64 -10.95 -0.56 2.92e-23 Type 2 diabetes; CESC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg25754956 chr12:51612065 POU6F1 0.76 8.46 0.46 1.8e-15 Cisplatin-induced ototoxicity; CESC trans rs11098499 0.754 rs66900435 chr4:120249425 C/A cg25214090 chr10:38739885 LOC399744 0.62 8.81 0.48 1.69e-16 Corneal astigmatism; CESC cis rs7084402 0.967 rs1658459 chr10:60299246 C/A cg07615347 chr10:60278583 BICC1 0.59 9.22 0.49 9.45e-18 Refractive error; CESC cis rs4700695 0.719 rs27080 chr5:65442271 A/G cg21114390 chr5:65439923 SFRS12 -0.5 -6.1 -0.35 3.72e-9 Facial morphology (factor 19); CESC trans rs3942852 0.545 rs7395231 chr11:48091689 T/C cg15704280 chr7:45808275 SEPT13 -0.73 -9.53 -0.51 1.06e-18 Acute lymphoblastic leukemia (childhood); CESC cis rs7814319 0.933 rs13261747 chr8:97238769 A/G cg20787634 chr8:97240163 UQCRB -0.63 -8.3 -0.45 5.32e-15 Lung function (FVC); CESC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg18876405 chr7:65276391 NA -0.55 -7.55 -0.42 7.19e-13 Aortic root size; CESC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs9389248 0.690 rs6569982 chr6:135256495 C/G cg22676075 chr6:135203613 NA 0.58 8.28 0.45 5.98e-15 High light scatter reticulocyte percentage of red cells; CESC cis rs62005083 0.867 rs62005153 chr14:74596115 G/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.63 5.09 0.3 6.69e-7 Mean corpuscular volume; CESC cis rs1483121 0.808 rs11039482 chr11:48009074 C/T cg20307385 chr11:47447363 PSMC3 0.71 6.41 0.37 6.47e-10 Fasting blood glucose (BMI interaction);Fasting blood glucose; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04621042 chr22:50169721 BRD1 0.48 6.32 0.36 1.11e-9 Fibrinogen levels; CESC cis rs2243480 1.000 rs36033484 chr7:65390558 T/G cg18252515 chr7:66147081 NA -1.18 -10.88 -0.56 5.02e-23 Diabetic kidney disease; CESC cis rs10465746 0.935 rs35946036 chr1:84438991 A/G cg10977910 chr1:84465055 TTLL7 0.47 6.43 0.37 6.02e-10 Obesity-related traits; CESC trans rs9929218 0.731 rs72785179 chr16:68767912 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -10.27 -0.53 4.68e-21 Colorectal cancer; CESC cis rs909674 0.775 rs8138462 chr22:39839670 G/C cg02038168 chr22:39784481 NA -0.66 -8.54 -0.46 1.09e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs58785573 0.570 rs4833078 chr4:38646476 C/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.51 7.09 0.4 1.19e-11 Lymphocyte percentage of white cells; CESC cis rs7267979 1.000 rs12428 chr20:25433821 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -17.58 -0.73 2.14e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs2249694 0.960 rs11101890 chr10:135421321 G/A cg20169779 chr10:135381914 SYCE1 -0.38 -5.5 -0.32 9.1e-8 Obesity-related traits; CESC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg08888203 chr3:10149979 C3orf24 0.53 6.83 0.39 5.8200000000000003e-11 Alzheimer's disease; CESC cis rs9486715 0.830 rs1475748 chr6:97034143 T/C cg18709589 chr6:96969512 KIAA0776 -0.46 -6.47 -0.37 4.79e-10 Headache; CESC cis rs10949834 0.824 rs2285025 chr7:73529976 T/C cg07137043 chr7:73588983 EIF4H -0.67 -5.8 -0.34 1.9e-8 Verbal memory performance (residualized delayed recall change); CESC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg07677032 chr17:61819896 STRADA 0.51 6.71 0.38 1.14e-10 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10911619 chr10:96162162 TBC1D12 0.61 7.13 0.4 9.53e-12 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs3008856 chr1:67387901 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.03 14.35 0.66 5.87e-35 Lymphocyte percentage of white cells; CESC cis rs2933343 0.679 rs1091938 chr3:128637025 T/C cg25356066 chr3:128598488 ACAD9 0.62 8.37 0.46 3.36e-15 IgG glycosylation; CESC cis rs644799 1.000 rs693364 chr11:95621926 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.6 7.36 0.41 2.31e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs494003 1.000 rs11227284 chr11:65503224 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.65 5.05 0.3 8.41e-7 Systemic lupus erythematosus; CESC cis rs8077889 0.917 rs72836547 chr17:41902799 G/T cg26893861 chr17:41843967 DUSP3 0.83 9.86 0.52 9.44e-20 Triglycerides; CESC cis rs3540 0.513 rs2589974 chr15:90891566 C/T cg22089800 chr15:90895588 ZNF774 -0.73 -10.22 -0.53 6.91e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs10484885 0.824 rs72919976 chr6:90526686 C/G cg13799429 chr6:90582589 CASP8AP2 -0.76 -7.17 -0.4 7.34e-12 QRS interval (sulfonylurea treatment interaction); CESC cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg05535760 chr7:792225 HEATR2 0.88 10.93 0.56 3.48e-23 Cerebrospinal P-tau181p levels; CESC cis rs2243480 1.000 rs57057549 chr7:65405738 A/G cg13147721 chr7:65941812 NA -0.88 -8.09 -0.45 2.17e-14 Diabetic kidney disease; CESC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg19163074 chr7:65112434 INTS4L2 0.42 5.28 0.31 2.63e-7 Aortic root size; CESC cis rs10782582 0.569 rs74090722 chr1:76197262 A/G cg22875332 chr1:76189707 ACADM -0.46 -5.57 -0.32 6.41e-8 Daytime sleep phenotypes; CESC cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg12365402 chr11:9010492 NRIP3 -0.44 -7.41 -0.41 1.65e-12 Hemoglobin concentration; CESC cis rs2228479 0.850 rs11649510 chr16:89851004 A/G cg00800038 chr16:89945340 TCF25 -0.91 -7.52 -0.42 8.29e-13 Skin colour saturation; CESC cis rs9287719 0.901 rs13034017 chr2:10739592 C/T cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs6694270 0.913 rs11261069 chr1:19117300 C/G cg19637330 chr1:19110922 NA -0.4 -5.2 -0.3 3.99e-7 Drug-induced liver injury (nitrofurantoin); CESC cis rs6089584 0.528 rs4925335 chr20:60627034 G/A cg06108461 chr20:60628389 TAF4 -0.61 -8.18 -0.45 1.16e-14 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17331554 chr14:105167820 INF2 0.46 6.71 0.38 1.18e-10 Fibrinogen levels; CESC cis rs9325144 0.647 rs7980932 chr12:38921583 G/T cg26384229 chr12:38710491 ALG10B -0.51 -7.18 -0.4 6.89e-12 Morning vs. evening chronotype; CESC cis rs9768139 0.935 rs7809076 chr7:158118438 C/T cg24154853 chr7:158122151 PTPRN2 -0.4 -6.51 -0.37 3.82e-10 Calcium levels; CESC cis rs911555 0.723 rs4906324 chr14:103923099 A/G cg12935359 chr14:103987150 CKB 0.65 9.62 0.51 5.7e-19 Intelligence (multi-trait analysis); CESC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.17e-12 Tonsillectomy; CESC cis rs73019876 0.869 rs2666457 chr19:22126880 T/C cg11619707 chr19:22235551 ZNF257 -0.29 -5.22 -0.31 3.61e-7 Testicular germ cell tumor; CESC cis rs7264396 0.563 rs6060567 chr20:34288250 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.87 0.39 4.47e-11 Total cholesterol levels; CESC trans rs9325144 0.600 rs6582630 chr12:38743508 A/G cg23762105 chr12:34175262 ALG10 0.48 6.44 0.37 5.66e-10 Morning vs. evening chronotype; CESC cis rs12464483 0.591 rs4952171 chr2:30886903 G/A cg17749961 chr2:30669863 LCLAT1 0.68 6.7 0.38 1.28e-10 Pre-treatment pain in head and neck squamous cell carcinoma; CESC cis rs4132509 1.000 rs7514984 chr1:243965623 C/T cg21452805 chr1:244014465 NA 0.43 5.32 0.31 2.18e-7 RR interval (heart rate); CESC cis rs7481584 1.000 rs12804412 chr11:3020782 G/A cg25174290 chr11:3078921 CARS -0.43 -5.36 -0.31 1.78e-7 Calcium levels; CESC cis rs28374715 0.617 rs16971733 chr15:41562030 C/A cg02330683 chr15:41787940 ITPKA 0.36 5.04 0.3 8.78e-7 Ulcerative colitis; CESC cis rs7927771 0.524 rs7933184 chr11:47682402 C/T cg18512352 chr11:47633146 NA 0.34 5.15 0.3 5.04e-7 Subjective well-being; CESC cis rs9435341 0.965 rs12401598 chr1:107580533 C/A cg09367891 chr1:107599246 PRMT6 0.71 8.35 0.46 3.78e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs9303280 0.806 rs9904624 chr17:38036586 A/G cg19468946 chr17:37922297 IKZF3 -0.41 -5.42 -0.32 1.31e-7 Self-reported allergy; CESC cis rs5758659 0.714 rs2284087 chr22:42485671 T/C cg04733989 chr22:42467013 NAGA -0.45 -6.36 -0.36 8.61e-10 Cognitive function; CESC cis rs9549367 0.577 rs3024713 chr13:113813321 G/A cg10067723 chr13:113807384 NA -0.44 -5.31 -0.31 2.34e-7 Platelet distribution width; CESC cis rs6662572 0.686 rs72677541 chr1:46561560 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.13 0.3 5.7e-7 Blood protein levels; CESC cis rs763121 0.853 rs3788544 chr22:39064966 C/T cg06544989 chr22:39130855 UNC84B 0.48 8.1 0.45 1.96e-14 Menopause (age at onset); CESC cis rs7659604 0.605 rs1396080 chr4:122740454 T/G cg06713675 chr4:122721982 EXOSC9 -0.43 -6.09 -0.35 4.03e-9 Type 2 diabetes; CESC cis rs17253792 0.822 rs10147380 chr14:56054354 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.83 6.03 0.35 5.45e-9 Putamen volume; CESC cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.14 -0.4 9.21e-12 Personality dimensions; CESC cis rs1020064 0.636 rs2679883 chr2:105949668 C/T cg02079111 chr2:105885981 TGFBRAP1 0.39 5.27 0.31 2.83e-7 AIDS; CESC cis rs6582630 0.555 rs10880520 chr12:38464111 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.11 0.35 3.63e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs1005277 0.502 rs2800484 chr10:38542415 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -5.68 -0.33 3.45e-8 Extrinsic epigenetic age acceleration; CESC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs1775715 0.769 rs2808102 chr10:32117749 A/T cg18675610 chr10:32216311 ARHGAP12 0.33 5.1 0.3 6.52e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26878967 chr11:66459081 SPTBN2 -0.68 -8.17 -0.45 1.27e-14 Gut microbiome composition (summer); CESC cis rs425277 1.000 rs262665 chr1:2083173 A/G cg04315214 chr1:2043799 PRKCZ -0.38 -5.3 -0.31 2.42e-7 Height; CESC cis rs12477438 0.798 rs1349779 chr2:99645055 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -11.02 -0.56 1.73e-23 Chronic sinus infection; CESC cis rs10779751 0.762 rs1074078 chr1:11326788 C/T cg08854313 chr1:11322531 MTOR -0.63 -7.92 -0.44 6.75e-14 Body mass index; CESC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg26314531 chr2:26401878 FAM59B -0.61 -6.85 -0.39 5.26e-11 Gut microbiome composition (summer); CESC cis rs3740713 1.000 rs73438674 chr11:18456889 T/C cg23797887 chr11:18477753 LDHAL6A -0.53 -5.27 -0.31 2.89e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg24130564 chr14:104152367 KLC1 -0.49 -6.53 -0.37 3.4e-10 Reticulocyte count; CESC cis rs11098499 0.789 rs1980024 chr4:120253047 C/T cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg17971929 chr21:40555470 PSMG1 -0.53 -6.93 -0.39 3.21e-11 Menarche (age at onset); CESC cis rs1008375 1.000 rs28693609 chr4:17645233 C/T cg16339924 chr4:17578868 LAP3 0.57 7.13 0.4 9.66e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs36051895 0.559 rs7874495 chr9:5209804 A/G cg02405213 chr9:5042618 JAK2 -0.49 -6.03 -0.35 5.56e-9 Pediatric autoimmune diseases; CESC cis rs1950626 0.750 rs34061904 chr14:101435974 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.83 11.29 0.57 2.14e-24 Pelvic organ prolapse (moderate/severe); CESC cis rs7587476 0.784 rs36086595 chr2:215680293 A/G cg04004882 chr2:215674386 BARD1 0.54 6.08 0.35 4.21e-9 Neuroblastoma; CESC cis rs4253772 0.591 rs9615935 chr22:46686115 T/G cg00784671 chr22:46762841 CELSR1 -0.57 -5.5 -0.32 8.75e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7851660 0.805 rs7038998 chr9:100662396 C/G cg13688889 chr9:100608707 NA -0.63 -8.96 -0.48 5.91e-17 Strep throat; CESC cis rs9929218 0.581 rs7203337 chr16:68774800 C/G cg02972257 chr16:68554789 NA -0.42 -5.29 -0.31 2.6e-7 Colorectal cancer; CESC cis rs6456156 0.586 rs720325 chr6:167467349 G/T cg23791538 chr6:167370224 RNASET2 -0.51 -6.52 -0.37 3.62e-10 Primary biliary cholangitis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06914050 chr7:56119237 PSPH;CCT6A -0.5 -6.52 -0.37 3.5e-10 Ulcerative colitis; CESC trans rs2018683 0.649 rs12536605 chr7:28970500 C/T cg19402173 chr7:128379420 CALU -0.5 -6.57 -0.37 2.64e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs9302635 0.515 rs36033103 chr16:72142038 G/T cg08717414 chr16:71523259 ZNF19 -0.9 -5.68 -0.33 3.63e-8 Blood protein levels; CESC cis rs644799 0.710 rs10765771 chr11:95521044 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.8 0.59 4.17e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3105593 1.000 rs17645649 chr15:50900370 A/G cg08437265 chr15:50716283 USP8 0.41 5.24 0.31 3.29e-7 QT interval; CESC cis rs4595586 0.679 rs4768473 chr12:39326256 A/G cg26384229 chr12:38710491 ALG10B 0.41 5.93 0.34 9.53e-9 Morning vs. evening chronotype; CESC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 10.35 0.54 2.68e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10791097 0.694 rs4264159 chr11:130755784 G/T cg09137382 chr11:130731461 NA 0.36 5.32 0.31 2.17e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.46 -5.6 -0.33 5.4e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 11.78 0.59 4.83e-26 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20990694 chr7:150417431 GIMAP1 -0.52 -6.43 -0.37 5.9e-10 Gut microbiome composition (summer); CESC cis rs11214589 0.651 rs11214595 chr11:113259658 G/T cg14159747 chr11:113255604 NA 0.33 5.96 0.34 7.95e-9 Neuroticism; CESC cis rs1448094 0.511 rs4897823 chr12:86161484 C/T cg00310523 chr12:86230176 RASSF9 0.32 5.19 0.3 4.23e-7 Major depressive disorder; CESC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg05234568 chr11:5960015 NA -0.57 -7.15 -0.4 8.67e-12 DNA methylation (variation); CESC cis rs7584330 0.554 rs13392410 chr2:238430273 G/A cg14458575 chr2:238380390 NA 0.48 5.3 0.31 2.4e-7 Prostate cancer; CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg24503407 chr1:205819492 PM20D1 0.92 16.78 0.72 1.49e-43 Menarche (age at onset); CESC cis rs1008375 1.000 rs28545485 chr4:17645376 C/T cg15017067 chr4:17643749 FAM184B 0.35 5.07 0.3 7.59e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9796 0.870 rs12910027 chr15:41283817 A/T cg18705301 chr15:41695430 NDUFAF1 0.44 6.5 0.37 4.03e-10 Menopause (age at onset); CESC cis rs7786808 0.741 rs11767875 chr7:158228923 A/G cg01191920 chr7:158217561 PTPRN2 -0.45 -8.1 -0.45 2.03e-14 Obesity-related traits; CESC cis rs4594175 0.926 rs12101170 chr14:51611902 T/C cg23942311 chr14:51606299 NA 0.36 5.43 0.32 1.29e-7 Cancer; CESC cis rs897984 0.609 rs12445650 chr16:31044897 G/A cg00531865 chr16:30841666 NA -0.39 -5.38 -0.31 1.64e-7 Dementia with Lewy bodies; CESC trans rs61931739 0.517 rs1486882 chr12:34025896 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.19 0.45 1.12e-14 Morning vs. evening chronotype; CESC cis rs2637266 1.000 rs2130795 chr10:78333892 C/G cg18941641 chr10:78392320 NA 0.42 7.93 0.44 6.07e-14 Pulmonary function; CESC trans rs17181170 0.574 rs9877721 chr3:87205485 G/C ch.2.199792288R chr2:200084043 NA -0.46 -6.08 -0.35 4.21e-9 Prostate cancer; CESC cis rs7647973 1.000 rs74471041 chr3:49542543 T/G cg06212747 chr3:49208901 KLHDC8B -0.59 -7.8 -0.43 1.43e-13 Menarche (age at onset); CESC cis rs4834770 1.000 rs2282688 chr4:120243722 T/C cg09307838 chr4:120376055 NA 0.45 5.37 0.31 1.74e-7 Blood protein levels; CESC cis rs8180040 0.966 rs6800271 chr3:47470787 A/T cg27129171 chr3:47204927 SETD2 -0.64 -9.95 -0.52 5.02e-20 Colorectal cancer; CESC cis rs17854409 0.764 rs8114722 chr20:61478492 G/A cg05147244 chr20:61493195 TCFL5 1.08 5.88 0.34 1.22e-8 Obesity-related traits; CESC cis rs9796 0.621 rs28737302 chr15:41469943 G/A cg12386646 chr15:41787261 ITPKA 0.33 5.08 0.3 7.11e-7 Menopause (age at onset); CESC cis rs826838 1.000 rs10880914 chr12:38720543 C/T cg13010199 chr12:38710504 ALG10B 0.62 8.83 0.48 1.5e-16 Heart rate; CESC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.61 -0.33 4.97e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1580019 0.587 rs7804457 chr7:32557981 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.73 0.38 1.05e-10 Cognitive ability; CESC cis rs10791097 0.739 rs11222358 chr11:130730497 G/A cg09137382 chr11:130731461 NA 0.4 5.92 0.34 9.71e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg10487699 chr11:57480176 TMX2;MED19 -0.46 -6.02 -0.35 5.89e-9 Recombination measurement; CESC cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg24101359 chr6:42928495 GNMT 0.55 7.85 0.43 1.02e-13 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9457247 0.534 rs933243 chr6:167403873 A/C cg25258033 chr6:167368657 RNASET2 0.39 5.74 0.33 2.59e-8 Crohn's disease; CESC cis rs34779708 0.931 rs72789609 chr10:35306206 C/T cg03585969 chr10:35415529 CREM 0.74 9.69 0.51 3.4e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs7408868 0.563 rs10423702 chr19:15300069 T/C cg14696996 chr19:15285081 NOTCH3 0.97 9.8 0.52 1.47e-19 Pulse pressure; CESC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg11366901 chr6:160182831 ACAT2 0.76 9.31 0.5 4.95e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs2486288 0.656 rs11632651 chr15:45550838 C/T cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs589448 0.902 rs642786 chr12:69758462 T/C cg22834771 chr12:69754056 YEATS4 -0.57 -7.68 -0.43 3.15e-13 Cerebrospinal fluid biomarker levels; CESC cis rs9291683 0.527 rs73212848 chr4:10093299 T/C cg11266682 chr4:10021025 SLC2A9 -0.56 -10.6 -0.55 4.1e-22 Bone mineral density; CESC cis rs858239 0.699 rs1881201 chr7:23194013 C/T cg23682824 chr7:23144976 KLHL7 -0.38 -5.17 -0.3 4.71e-7 Cerebrospinal fluid biomarker levels; CESC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg18479299 chr3:125709523 NA -0.45 -5.5 -0.32 8.73e-8 Blood pressure (smoking interaction); CESC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.88 6.3 0.36 1.21e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs42648 0.837 rs10262472 chr7:89900383 T/C cg23697855 chr7:89950296 NA 0.27 5.14 0.3 5.24e-7 Homocysteine levels; CESC cis rs9393777 0.588 rs4518487 chr6:26467531 A/G cg12826209 chr6:26865740 GUSBL1 0.59 7.13 0.4 9.69e-12 Intelligence (multi-trait analysis); CESC cis rs1707322 0.752 rs6678444 chr1:46229847 A/G cg03146154 chr1:46216737 IPP 0.8 11.41 0.57 8.33e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9300255 0.739 rs11057210 chr12:123733799 A/G cg19016782 chr12:123741754 C12orf65 -0.49 -7.03 -0.4 1.75e-11 Neutrophil percentage of white cells; CESC trans rs11098499 0.863 rs3775848 chr4:120447724 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.68 0.51 3.69e-19 Corneal astigmatism; CESC cis rs1005277 0.540 rs1814077 chr10:37992018 G/C cg25427524 chr10:38739819 LOC399744 -0.66 -9.58 -0.51 7.33e-19 Extrinsic epigenetic age acceleration; CESC cis rs7481584 0.669 rs12793371 chr11:3034709 A/G cg25174290 chr11:3078921 CARS -0.45 -6.07 -0.35 4.48e-9 Calcium levels; CESC cis rs6964587 0.647 rs38801 chr7:92046327 G/T cg17063962 chr7:91808500 NA -0.5 -6.55 -0.37 2.91e-10 Breast cancer; CESC cis rs1267303 0.637 rs1745371 chr1:46985192 C/T cg25110126 chr1:46999211 NA 0.71 8.78 0.47 2.11e-16 Monobrow; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03762820 chr2:43823654 THADA -0.45 -6.15 -0.35 2.88e-9 Gut microbiota (bacterial taxa); CESC cis rs7259376 0.905 rs114170435 chr19:22562522 C/A cg02657401 chr19:22469223 NA -0.26 -5.18 -0.3 4.47e-7 Menopause (age at onset); CESC cis rs80282103 0.867 rs3793781 chr10:1081293 G/T cg08668510 chr10:1095578 IDI1 0.65 5.03 0.3 8.89e-7 Glomerular filtration rate (creatinine); CESC cis rs950776 0.518 rs1504545 chr15:78818471 C/G cg06917634 chr15:78832804 PSMA4 -0.76 -11.0 -0.56 1.9e-23 Sudden cardiac arrest; CESC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.05 0.56 1.38e-23 Alzheimer's disease; CESC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg00409905 chr10:38381863 ZNF37A -0.44 -5.86 -0.34 1.36e-8 Breast cancer; CESC cis rs11623869 0.614 rs11627052 chr14:103863476 A/G cg12935359 chr14:103987150 CKB 0.59 6.68 0.38 1.39e-10 Bone mineral density; CESC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg24399712 chr22:39784796 NA 0.75 9.79 0.52 1.66e-19 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19322864 chr10:51572718 NCOA4 0.42 6.03 0.35 5.42e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11638352 1.000 rs2733204 chr15:44417012 A/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs9911578 0.967 rs2333410 chr17:57137129 G/A cg12560992 chr17:57184187 TRIM37 -0.97 -16.6 -0.71 6.75e-43 Intelligence (multi-trait analysis); CESC cis rs11645898 0.745 rs55824906 chr16:72064905 A/G cg14768367 chr16:72042858 DHODH -0.84 -6.92 -0.39 3.43e-11 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01307007 chr19:3522587 FZR1 -0.59 -6.64 -0.38 1.79e-10 Gut microbiome composition (summer); CESC cis rs7084402 0.935 rs10826202 chr10:60359091 C/T cg07615347 chr10:60278583 BICC1 0.54 8.25 0.45 7.48e-15 Refractive error; CESC cis rs7188697 0.922 rs7186997 chr16:58603348 A/G cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs36051895 0.587 rs7036761 chr9:5198781 A/C cg02405213 chr9:5042618 JAK2 0.51 6.03 0.35 5.43e-9 Pediatric autoimmune diseases; CESC cis rs10242455 0.867 rs2740558 chr7:99324743 T/C cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs67311347 0.955 rs73078170 chr3:40483947 C/T cg24209194 chr3:40518798 ZNF619 0.53 6.41 0.37 6.66e-10 Renal cell carcinoma; CESC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs344364 0.511 rs337286 chr16:1965719 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.6 -6.41 -0.37 6.63e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs6963495 0.745 rs73190179 chr7:105162812 C/A cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg26939375 chr7:64535504 NA 0.76 10.99 0.56 2.15e-23 Aortic root size; CESC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.31e-9 Developmental language disorder (linguistic errors); CESC cis rs9457247 1.000 rs1819333 chr6:167373547 G/T cg07741184 chr6:167504864 NA 0.29 5.17 0.3 4.71e-7 Crohn's disease; CESC cis rs847577 0.609 rs6465657 chr7:97816327 C/T cg21770322 chr7:97807741 LMTK2 0.85 14.37 0.66 5.23e-35 Breast cancer; CESC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg10883421 chr6:151773342 RMND1;C6orf211 0.83 13.29 0.63 3.11e-31 Menarche (age at onset); CESC cis rs6831352 0.744 rs2602847 chr4:100025963 T/C cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.21e-14 Alcohol dependence; CESC trans rs11098499 0.697 rs10020027 chr4:120381879 G/C cg25214090 chr10:38739885 LOC399744 0.7 9.91 0.52 6.89e-20 Corneal astigmatism; CESC cis rs7178572 0.568 rs4886866 chr15:77696166 A/T cg22256960 chr15:77711686 NA -0.55 -6.96 -0.39 2.61e-11 Type 2 diabetes; CESC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg18016565 chr1:150552671 MCL1 0.33 5.13 0.3 5.67e-7 Tonsillectomy; CESC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg17143192 chr8:8559678 CLDN23 0.74 8.41 0.46 2.57e-15 Obesity-related traits; CESC cis rs4474465 0.703 rs10899547 chr11:78254720 C/T cg27205649 chr11:78285834 NARS2 0.43 5.39 0.31 1.52e-7 Alzheimer's disease (survival time); CESC cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg23172400 chr8:95962367 TP53INP1 0.42 7.09 0.4 1.22e-11 Type 2 diabetes; CESC cis rs1847202 0.592 rs13073005 chr3:72951007 C/T cg10804678 chr3:72788309 NA -0.41 -5.38 -0.31 1.63e-7 Motion sickness; CESC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.18 0.76 5.16e-52 Height; CESC trans rs6084875 0.641 rs6037946 chr20:4724693 A/G cg10192164 chr16:30419175 ZNF771 -0.51 -6.18 -0.35 2.44e-9 Systemic lupus erythematosus; CESC cis rs11190604 1.000 rs2495750 chr10:102327708 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.09 0.3 6.72e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs3749237 0.595 rs11720264 chr3:49580347 C/T cg02487422 chr3:49467188 NICN1 0.55 8.04 0.44 2.95e-14 Resting heart rate; CESC cis rs7100689 0.784 rs7078075 chr10:82162768 A/G cg00277334 chr10:82204260 NA -0.59 -7.32 -0.41 3.05e-12 Post bronchodilator FEV1; CESC cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs644799 1.000 rs563653 chr11:95561488 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.57e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs113835537 0.935 rs1127145 chr11:66373305 G/A cg24851651 chr11:66362959 CCS 0.62 5.6 0.33 5.26e-8 Airway imaging phenotypes; CESC cis rs1443512 0.812 rs1561987 chr12:54335268 C/T cg17410650 chr12:54324560 NA -0.39 -6.53 -0.37 3.39e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs113835537 0.529 rs17495838 chr11:66196265 T/C cg24851651 chr11:66362959 CCS 0.56 6.51 0.37 3.65e-10 Airway imaging phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11855615 chr17:33817136 SLFN12L -0.51 -6.08 -0.35 4.28e-9 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs12041926 chr1:67434602 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.04 14.47 0.66 2.27e-35 Lymphocyte percentage of white cells; CESC cis rs919433 1.000 rs919433 chr2:198166565 G/A cg10820045 chr2:198174542 NA -0.41 -6.27 -0.36 1.45e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg17372223 chr3:52568218 NT5DC2 0.51 8.0 0.44 3.82e-14 Electroencephalogram traits; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.5.409282R chr5:15780558 FBXL7 -0.47 -6.49 -0.37 4.21e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1348850 0.914 rs4893944 chr2:178289357 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.75 10.4 0.54 1.82e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs929354 0.772 rs1182442 chr7:157026633 G/A cg05182265 chr7:156933206 UBE3C 0.5 7.33 0.41 2.87e-12 Body mass index; CESC cis rs963731 0.579 rs4670902 chr2:39220904 A/T cg04010122 chr2:39346883 SOS1 -0.57 -5.07 -0.3 7.42e-7 Corticobasal degeneration; CESC cis rs4919694 0.611 rs77328741 chr10:105066314 T/C cg04362960 chr10:104952993 NT5C2 0.68 5.59 0.32 5.56e-8 Arsenic metabolism; CESC cis rs2197308 0.765 rs12230545 chr12:37927114 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.08 -0.44 2.34e-14 Morning vs. evening chronotype; CESC cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg12311346 chr5:56204834 C5orf35 -0.41 -5.16 -0.3 4.75e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01990225 chr2:97406019 LMAN2L -0.66 -7.3 -0.41 3.41e-12 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23236025 chr1:109826094 PSRC1 -0.52 -6.3 -0.36 1.25e-9 Ulcerative colitis; CESC cis rs9303401 0.538 rs12603174 chr17:56489279 T/C cg12560992 chr17:57184187 TRIM37 0.5 5.03 0.3 8.86e-7 Cognitive test performance; CESC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.46 5.52 0.32 7.91e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg04578304 chr7:75796096 NA -0.42 -6.19 -0.36 2.23e-9 Vertical cup-disc ratio; CESC cis rs7592578 0.882 rs58568707 chr2:191468987 G/A cg10560079 chr2:191398806 TMEM194B -0.68 -6.16 -0.35 2.74e-9 Diastolic blood pressure; CESC cis rs593982 0.843 rs680948 chr11:65472394 C/G cg08755490 chr11:65554678 OVOL1 1.13 10.31 0.54 3.48e-21 Atopic dermatitis; CESC cis rs9393777 0.588 rs6933213 chr6:26493909 T/C cg12826209 chr6:26865740 GUSBL1 0.6 7.02 0.4 1.89e-11 Intelligence (multi-trait analysis); CESC trans rs3942852 0.774 rs10838812 chr11:48186924 T/C cg15704280 chr7:45808275 SEPT13 -0.73 -8.25 -0.45 7.61e-15 Acute lymphoblastic leukemia (childhood); CESC cis rs6456156 0.792 rs10946215 chr6:167516181 A/G cg23791538 chr6:167370224 RNASET2 0.42 5.2 0.3 3.99e-7 Primary biliary cholangitis; CESC cis rs734999 0.549 rs2764840 chr1:2529437 C/T cg20673091 chr1:2541236 MMEL1 -0.44 -7.49 -0.42 1.01e-12 Ulcerative colitis; CESC cis rs6840360 0.517 rs4399967 chr4:152729312 T/A cg22705602 chr4:152727874 NA 0.37 5.07 0.3 7.31e-7 Intelligence (multi-trait analysis); CESC cis rs9443645 0.810 rs9361482 chr6:79750385 T/C cg05283184 chr6:79620031 NA -0.4 -6.07 -0.35 4.46e-9 Intelligence (multi-trait analysis); CESC cis rs929354 0.566 rs6979947 chr7:157005863 C/T cg05182265 chr7:156933206 UBE3C 0.43 6.05 0.35 4.87e-9 Body mass index; CESC cis rs6543140 0.964 rs10169192 chr2:103072211 A/G cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs752010 0.695 rs10890156 chr1:42108090 T/C cg06885757 chr1:42089581 HIVEP3 0.49 7.86 0.43 9.43e-14 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11098499 0.954 rs7436506 chr4:120393769 T/C cg25214090 chr10:38739885 LOC399744 0.7 10.29 0.53 4.26e-21 Corneal astigmatism; CESC cis rs3762637 0.941 rs77599736 chr3:122179509 A/T cg24169773 chr3:122142474 KPNA1 -0.53 -6.17 -0.35 2.56e-9 LDL cholesterol levels; CESC trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21659725 chr3:3221576 CRBN -0.82 -13.5 -0.64 5.74e-32 Intelligence (multi-trait analysis); CESC cis rs116095464 0.558 rs13356367 chr5:242395 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.27 0.31 2.9e-7 Breast cancer; CESC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.07 -0.35 4.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.99 10.09 0.53 1.82e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs72781680 0.898 rs17763224 chr2:24213776 T/C cg08917208 chr2:24149416 ATAD2B 0.92 8.28 0.45 6.31e-15 Lymphocyte counts; CESC cis rs6430585 0.528 rs75667274 chr2:136682486 C/T cg07169764 chr2:136633963 MCM6 1.22 14.89 0.67 7.4e-37 Corneal structure; CESC cis rs9291683 0.655 rs35750364 chr4:10049049 T/C cg02734326 chr4:10020555 SLC2A9 0.47 6.53 0.37 3.3e-10 Bone mineral density; CESC cis rs12971120 0.947 rs4891559 chr18:72170397 C/T cg25817165 chr18:72167213 CNDP2 -0.58 -8.46 -0.46 1.84e-15 Refractive error; CESC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.53 8.02 0.44 3.41e-14 Bipolar disorder; CESC cis rs67478160 0.643 rs6575999 chr14:104250609 C/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.11 -0.4 1.09e-11 Schizophrenia; CESC trans rs1945213 0.694 rs67394518 chr11:55855303 G/A cg15704280 chr7:45808275 SEPT13 0.75 6.95 0.39 2.83e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs10779751 1.000 rs7544489 chr1:11299511 A/G cg08854313 chr1:11322531 MTOR -0.91 -14.27 -0.66 1.13e-34 Body mass index; CESC cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg07697082 chr8:82753677 SNX16 0.38 5.25 0.31 3.07e-7 Diastolic blood pressure; CESC trans rs1814175 0.645 rs7928714 chr11:49887622 G/A cg11707556 chr5:10655725 ANKRD33B -0.41 -6.15 -0.35 2.81e-9 Height; CESC cis rs3749237 0.595 rs1568661 chr3:49520958 A/G cg06212747 chr3:49208901 KLHDC8B 0.52 6.87 0.39 4.47e-11 Resting heart rate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17140673 chr4:111117400 ELOVL6 -0.44 -6.79 -0.38 7.47e-11 Gambling; CESC cis rs4237845 0.537 rs11172369 chr12:58280592 T/C cg00677455 chr12:58241039 CTDSP2 0.79 10.54 0.54 6.21e-22 Intelligence (multi-trait analysis); CESC cis rs17666538 0.591 rs2878547 chr8:603416 G/A cg07234876 chr8:600039 NA 0.8 6.57 0.37 2.7e-10 IgG glycosylation; CESC cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg22823121 chr1:150693482 HORMAD1 -0.37 -5.38 -0.31 1.61e-7 Tonsillectomy; CESC cis rs13034020 0.522 rs13005116 chr2:61241567 G/C cg18625361 chr2:61244694 PEX13;PUS10 0.66 5.9 0.34 1.13e-8 Hodgkin's lymphoma; CESC cis rs7692995 1.000 rs16896128 chr4:17953590 A/G cg08925142 chr4:18023851 LCORL -0.45 -5.39 -0.31 1.58e-7 Height; CESC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.64 0.38 1.79e-10 Prudent dietary pattern; CESC cis rs2011503 0.882 rs113841472 chr19:19565482 T/G cg11584989 chr19:19387371 SF4 0.62 7.24 0.41 4.98e-12 Bipolar disorder; CESC cis rs9549367 0.789 rs9549711 chr13:113900557 C/T cg00898013 chr13:113819073 PROZ -0.53 -7.21 -0.41 5.74e-12 Platelet distribution width; CESC cis rs6964587 1.000 rs28927678 chr7:91715662 C/T cg17063962 chr7:91808500 NA 0.53 7.03 0.4 1.78e-11 Breast cancer; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg12952568 chr14:21924005 NA 0.51 6.26 0.36 1.56e-9 Retinol levels; CESC cis rs3862260 0.509 rs3862262 chr1:120161841 G/T cg16322792 chr1:120165303 ZNF697 0.6 11.5 0.58 4.43e-25 Systemic lupus erythematosus; CESC cis rs4973397 0.509 rs10191571 chr2:232279975 C/A cg09339159 chr2:232260559 B3GNT7 0.5 6.18 0.36 2.37e-9 Anti-saccade response; CESC cis rs2243480 1.000 rs6958420 chr7:65751171 A/G cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg17971929 chr21:40555470 PSMG1 -0.86 -12.5 -0.61 1.77e-28 Cognitive function; CESC cis rs7208859 0.623 rs73271842 chr17:29137155 T/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12142240 0.698 rs58162700 chr1:46816659 T/A cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs7208859 0.573 rs55661352 chr17:29045628 A/G cg19761014 chr17:28927070 LRRC37B2 0.79 6.32 0.36 1.1e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg11764359 chr7:65958608 NA -0.73 -10.44 -0.54 1.38e-21 Aortic root size; CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg25934064 chr3:52569026 NT5DC2 0.26 5.4 0.32 1.45e-7 Bipolar disorder; CESC cis rs12530845 1.000 rs6975251 chr7:135328689 C/G cg23117316 chr7:135346802 PL-5283 -0.41 -5.29 -0.31 2.52e-7 Red blood cell traits; CESC cis rs2625529 0.938 rs2742323 chr15:72116778 A/T cg16672083 chr15:72433130 SENP8 0.42 5.38 0.31 1.66e-7 Red blood cell count; CESC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.44 0.5 1.97e-18 Menopause (age at onset); CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg07520141 chr5:10564205 ANKRD33B -0.56 -6.4 -0.37 7.2e-10 Subjective well-being; CESC cis rs2832077 0.506 rs2832081 chr21:30152992 A/C cg08807101 chr21:30365312 RNF160 0.46 5.3 0.31 2.38e-7 Cognitive test performance; CESC trans rs28549925 0.590 rs1403803 chr7:16989678 A/G cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.83e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs60843830 0.661 rs7561648 chr2:105171 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.51 6.08 0.35 4.11e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg20151795 chr6:28129481 ZNF389 0.46 5.83 0.34 1.65e-8 Depression; CESC cis rs950169 0.840 rs62019457 chr15:85102142 T/C cg17507749 chr15:85114479 UBE2QP1 0.56 6.24 0.36 1.7e-9 Schizophrenia; CESC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg02034447 chr16:89574710 SPG7 0.54 6.99 0.39 2.22e-11 Multiple myeloma (IgH translocation); CESC cis rs6665290 0.904 rs6426559 chr1:227195876 T/C cg10327440 chr1:227177885 CDC42BPA -1.22 -32.88 -0.9 1.62e-95 Myeloid white cell count; CESC cis rs763014 0.931 rs11648728 chr16:635525 C/T cg07343612 chr16:622815 PIGQ -0.55 -7.99 -0.44 4.25e-14 Height; CESC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg06634786 chr22:41940651 POLR3H 0.58 6.31 0.36 1.14e-9 Vitiligo; CESC cis rs17253792 0.822 rs8006705 chr14:56171283 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.64 5.08 0.3 7.04e-7 Putamen volume; CESC cis rs1691799 0.867 rs1168344 chr12:66758213 G/A cg16791601 chr12:66731901 HELB -0.79 -14.13 -0.66 3.73e-34 White blood cell count (basophil); CESC cis rs10504229 0.679 rs6474100 chr8:58031161 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -5.93 -0.34 9.43e-9 Developmental language disorder (linguistic errors); CESC cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg00149659 chr3:10157352 C3orf10 1.01 12.47 0.61 2.12e-28 Alzheimer's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06666157 chr19:4791552 FEM1A 0.55 7.2 0.4 6.3e-12 Gut microbiota (bacterial taxa); CESC cis rs4925386 0.840 rs6143024 chr20:60914229 A/G cg24112000 chr20:60950667 NA -0.51 -6.15 -0.35 2.86e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs977987 0.843 rs11860231 chr16:75385159 A/G cg03315344 chr16:75512273 CHST6 0.4 5.82 0.34 1.72e-8 Dupuytren's disease; CESC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.45 5.51 0.32 8.43e-8 Tonsillectomy; CESC cis rs9905704 0.918 rs11650343 chr17:56919549 G/A cg12560992 chr17:57184187 TRIM37 0.6 7.02 0.4 1.81e-11 Testicular germ cell tumor; CESC cis rs662064 0.928 rs685746 chr1:10537437 C/G cg20482658 chr1:10539492 PEX14 -0.36 -7.11 -0.4 1.11e-11 Asthma; CESC cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg10523679 chr1:76189770 ACADM -0.53 -5.54 -0.32 7.22e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2242116 0.796 rs4683297 chr3:46973673 T/C cg02527881 chr3:46936655 PTH1R 0.52 7.28 0.41 3.69e-12 Birth weight; CESC cis rs1801251 1.000 rs11679079 chr2:233612656 C/T cg25237894 chr2:233734115 C2orf82 0.45 7.84 0.43 1.1e-13 Coronary artery disease; CESC trans rs74054849 0.850 rs72878889 chr1:16014128 C/T cg06826283 chr7:600452 PRKAR1B 0.63 6.0 0.35 6.35e-9 Alcoholic chronic pancreatitis; CESC cis rs16854884 1.000 rs13067695 chr3:143781054 C/T cg06585982 chr3:143692056 C3orf58 0.46 5.69 0.33 3.34e-8 Economic and political preferences (feminism/equality); CESC cis rs9611565 0.649 rs5751108 chr22:41858035 T/C cg17376030 chr22:41985996 PMM1 -0.74 -7.87 -0.44 9.15e-14 Vitiligo; CESC cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg25405998 chr7:65216604 CCT6P1 0.5 5.39 0.31 1.53e-7 Aortic root size; CESC cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11098499 0.954 rs35091806 chr4:120325529 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs2479724 0.868 rs2249703 chr6:41814760 A/G cg17623882 chr6:41773611 USP49 -0.4 -5.79 -0.34 1.95e-8 Menarche (age at onset); CESC cis rs11676348 0.783 rs4674252 chr2:218984478 G/A cg00012203 chr2:219082015 ARPC2 -0.56 -7.31 -0.41 3.18e-12 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24854085 chr5:95158523 GLRX -0.68 -7.28 -0.41 3.74e-12 Gut microbiome composition (summer); CESC cis rs4132509 1.000 rs10927059 chr1:243852079 T/C cg21452805 chr1:244014465 NA 0.42 5.03 0.3 8.87e-7 RR interval (heart rate); CESC cis rs7824557 0.707 rs3808519 chr8:11142970 C/G cg21775007 chr8:11205619 TDH 0.47 6.94 0.39 3.05e-11 Retinal vascular caliber; CESC cis rs4927850 0.709 rs6765762 chr3:195652851 G/A cg00031303 chr3:195681400 NA 0.76 9.54 0.51 9.8e-19 Pancreatic cancer; CESC cis rs11971779 0.941 rs7800795 chr7:139080348 A/G cg07862535 chr7:139043722 LUC7L2 0.56 5.81 0.34 1.82e-8 Diisocyanate-induced asthma; CESC cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg03433033 chr1:76189801 ACADM 0.7 9.34 0.5 4.14e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10883723 0.775 rs2296579 chr10:104241375 A/G cg22532475 chr10:104410764 TRIM8 -0.32 -5.43 -0.32 1.27e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg07677032 chr17:61819896 STRADA 0.44 5.81 0.34 1.78e-8 Prudent dietary pattern; CESC cis rs950169 1.000 rs35297609 chr15:84772896 A/G cg17507749 chr15:85114479 UBE2QP1 0.6 6.5 0.37 3.92e-10 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05309454 chr17:79791505 FAM195B;DYSFIP1 0.52 6.32 0.36 1.09e-9 Gut microbiome composition (summer); CESC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs589448 0.902 rs528974 chr12:69765918 A/T cg14784868 chr12:69753453 YEATS4 0.89 14.22 0.66 1.68e-34 Cerebrospinal fluid biomarker levels; CESC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg20243544 chr17:37824526 PNMT 0.48 5.93 0.34 9.26e-9 Urinary metabolites; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14971544 chr1:54955149 NA 0.55 6.98 0.39 2.36e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.513 rs739135 chr22:42090069 A/C cg17376030 chr22:41985996 PMM1 -0.78 -8.3 -0.45 5.4e-15 Vitiligo; CESC cis rs8078723 0.933 rs4794822 chr17:38156712 C/T cg17467752 chr17:38218738 THRA 0.7 10.65 0.55 2.78e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg11301795 chr4:187892539 NA -0.72 -10.9 -0.56 4.33e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg05863683 chr7:1912471 MAD1L1 -0.43 -6.64 -0.38 1.76e-10 Bipolar disorder and schizophrenia; CESC trans rs62103177 0.564 rs2115996 chr18:77701007 C/G cg05926928 chr17:57297772 GDPD1 0.83 7.77 0.43 1.76e-13 Opioid sensitivity; CESC cis rs710216 1.000 rs710216 chr1:43428757 A/G cg07803811 chr1:43423981 SLC2A1 0.47 5.03 0.3 9.03e-7 Red cell distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07005173 chr17:7977057 ALOX12B -0.54 -6.35 -0.36 9.12e-10 Gut microbiome composition (summer); CESC cis rs3780486 0.757 rs10121987 chr9:33119818 A/G cg13443165 chr9:33130375 B4GALT1 0.44 6.37 0.36 8.22e-10 IgG glycosylation; CESC cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg12826209 chr6:26865740 GUSBL1 0.75 8.23 0.45 8.34e-15 Intelligence (multi-trait analysis); CESC cis rs4660306 0.961 rs12082256 chr1:45951380 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.67 -0.43 3.26e-13 Homocysteine levels; CESC cis rs116095464 0.558 rs6555052 chr5:224268 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.72 -0.47 3.15e-16 Breast cancer; CESC cis rs710216 0.917 rs4660691 chr1:43417150 T/G cg07803811 chr1:43423981 SLC2A1 -0.48 -5.17 -0.3 4.61e-7 Red cell distribution width; CESC cis rs3857067 1.000 rs12502725 chr4:94999873 T/C cg11021082 chr4:95130006 SMARCAD1 -0.51 -7.64 -0.42 3.98e-13 QT interval; CESC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg13647721 chr17:30228624 UTP6 -0.63 -5.87 -0.34 1.31e-8 Hip circumference adjusted for BMI; CESC cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg02353165 chr6:42928485 GNMT -0.62 -7.09 -0.4 1.24e-11 Blood protein levels; CESC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg08470875 chr2:26401718 FAM59B 0.55 6.06 0.35 4.56e-9 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs1054400 chr17:29109954 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.55 0.37 3.04e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6942756 0.747 rs692432 chr7:129113287 G/A cg02491457 chr7:128862824 NA -0.57 -7.83 -0.43 1.18e-13 White matter hyperintensity burden; CESC cis rs643506 0.715 rs11214031 chr11:111766039 C/A cg17089665 chr11:111648010 NA -0.39 -5.68 -0.33 3.46e-8 Breast cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20420867 chr1:160175396 PEA15 -0.44 -6.28 -0.36 1.37e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6500602 0.674 rs8051695 chr16:4536621 T/C cg08645402 chr16:4508243 NA 0.43 6.69 0.38 1.35e-10 Schizophrenia; CESC cis rs2228479 0.850 rs62052714 chr16:89857180 T/C cg04013166 chr16:89971882 TCF25 0.78 6.67 0.38 1.44e-10 Skin colour saturation; CESC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg06873352 chr17:61820015 STRADA 0.47 6.85 0.39 5.3e-11 Height; CESC cis rs6460942 0.908 rs6948654 chr7:12418546 T/A cg16278512 chr7:12443529 VWDE -0.5 -5.21 -0.31 3.71e-7 Coronary artery disease; CESC cis rs748404 0.631 rs11070399 chr15:43646347 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.71 0.43 2.5e-13 Lung cancer; CESC cis rs7267979 0.844 rs6050477 chr20:25221547 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.66 -11.43 -0.57 7.25e-25 Liver enzyme levels (alkaline phosphatase); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg07496882 chr10:112631570 LOC282997;PDCD4 0.48 6.54 0.37 3.22e-10 Bronchopulmonary dysplasia; CESC cis rs873946 0.557 rs4880427 chr10:134591389 T/C cg26818010 chr10:134567672 INPP5A -0.95 -11.6 -0.58 2.03e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6754311 0.731 rs745500 chr2:136583192 G/A cg07169764 chr2:136633963 MCM6 -0.69 -8.44 -0.46 2.16e-15 Mosquito bite size; CESC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg02725872 chr8:58115012 NA -0.44 -6.1 -0.35 3.84e-9 Developmental language disorder (linguistic errors); CESC cis rs7845219 0.525 rs10956931 chr8:95930301 A/G cg16049864 chr8:95962084 TP53INP1 -0.44 -6.25 -0.36 1.59e-9 Type 2 diabetes; CESC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg07677032 chr17:61819896 STRADA 0.45 6.06 0.35 4.7e-9 Prudent dietary pattern; CESC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.43 0.37 6.06e-10 Bipolar disorder; CESC cis rs3762637 1.000 rs9879508 chr3:122136480 A/G cg24169773 chr3:122142474 KPNA1 -0.51 -6.03 -0.35 5.56e-9 LDL cholesterol levels; CESC cis rs4342066 0.522 rs4680746 chr3:28278165 C/G cg15038811 chr3:28283857 CMC1 0.39 5.1 0.3 6.38e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg19774624 chr17:42201019 HDAC5 0.83 12.85 0.62 1.02e-29 Total body bone mineral density; CESC cis rs13242816 1.000 rs7796429 chr7:116144369 T/C cg04696780 chr7:116139425 CAV2 -0.61 -5.55 -0.32 7.01e-8 P wave duration; CESC cis rs7605827 0.836 rs9287662 chr2:15595994 A/G cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC cis rs12971120 0.891 rs11151960 chr18:72177232 G/A cg25817165 chr18:72167213 CNDP2 -0.62 -7.54 -0.42 7.61e-13 Refractive error; CESC cis rs7762018 1.000 rs6912959 chr6:170126224 G/A cg05834625 chr6:170176447 C6orf70 0.66 7.77 0.43 1.75e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg10691866 chr7:65817282 TPST1 -0.33 -5.63 -0.33 4.48e-8 Aortic root size; CESC cis rs4268898 0.662 rs2303291 chr2:24431184 C/T cg08917208 chr2:24149416 ATAD2B 0.54 5.18 0.3 4.48e-7 Asthma; CESC cis rs17253792 0.822 rs74053651 chr14:56125366 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.78 0.33 2.08e-8 Putamen volume; CESC cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.41 0.32 1.39e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs7213347 0.780 rs1555568 chr17:2149505 T/C cg16127145 chr16:1842146 IGFALS -0.43 -6.05 -0.35 4.91e-9 Total body bone mineral density; CESC cis rs367943 0.712 rs7714734 chr5:112691261 G/A cg12552261 chr5:112820674 MCC 0.43 5.55 0.32 6.89e-8 Type 2 diabetes; CESC cis rs709400 0.663 rs3783402 chr14:103967929 C/G cg12935359 chr14:103987150 CKB -0.52 -7.53 -0.42 8.19e-13 Body mass index; CESC cis rs12477438 0.520 rs1133978 chr2:99741964 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.85 0.62 1.02e-29 Chronic sinus infection; CESC cis rs6499129 0.558 rs7191281 chr16:67655133 T/C cg26727032 chr16:67993705 SLC12A4 -0.56 -5.98 -0.34 7.22e-9 Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04381043 chr16:89341467 ANKRD11 -0.57 -6.42 -0.37 6.21e-10 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07417990 chr1:224051868 NA 0.42 6.09 0.35 3.87e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs35146811 0.659 rs863450 chr7:99821685 C/T cg13215871 chr17:75784724 NA -0.34 -6.39 -0.37 7.46e-10 Coronary artery disease; CESC cis rs77861329 0.748 rs9851576 chr3:52091254 C/T cg08692210 chr3:52188851 WDR51A -0.44 -5.14 -0.3 5.29e-7 Macrophage inflammatory protein 1b levels; CESC cis rs5758511 0.680 rs58654759 chr22:42642576 T/C cg00645731 chr22:42541494 CYP2D7P1 0.57 8.33 0.46 4.29e-15 Birth weight; CESC cis rs4654899 0.733 rs10916907 chr1:21261088 A/C cg05370193 chr1:21551575 ECE1 0.38 5.72 0.33 2.83e-8 Superior frontal gyrus grey matter volume; CESC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg06420487 chr17:61919686 SMARCD2 0.44 5.28 0.31 2.68e-7 Height; CESC cis rs4076764 0.958 rs10917748 chr1:163400377 T/C cg06092702 chr1:163392909 NA -0.41 -5.9 -0.34 1.13e-8 Motion sickness; CESC cis rs17376456 0.825 rs12188163 chr5:93250608 A/G cg21475434 chr5:93447410 FAM172A -0.76 -6.58 -0.37 2.51e-10 Diabetic retinopathy; CESC cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg15017067 chr4:17643749 FAM184B 0.36 5.18 0.3 4.44e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg17376030 chr22:41985996 PMM1 0.78 8.18 0.45 1.17e-14 Vitiligo; CESC cis rs9435341 0.762 rs72697623 chr1:107554269 G/A cg09367891 chr1:107599246 PRMT6 0.66 7.1 0.4 1.16e-11 Facial morphology (factor 21, depth of nasal alae); CESC cis rs9916302 0.610 rs11078902 chr17:37631883 C/G cg07936489 chr17:37558343 FBXL20 -0.8 -11.68 -0.58 1.06e-25 Glomerular filtration rate (creatinine); CESC cis rs8060686 0.641 rs9938553 chr16:68183064 T/A cg26727032 chr16:67993705 SLC12A4 -0.5 -6.15 -0.35 2.84e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs6964587 0.692 rs10236483 chr7:91797296 A/C cg17063962 chr7:91808500 NA 0.44 6.38 0.36 7.97e-10 Breast cancer; CESC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg00484396 chr16:3507460 NAT15 0.61 7.64 0.42 3.99e-13 Tuberculosis; CESC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg00166722 chr3:10149974 C3orf24 0.46 5.88 0.34 1.21e-8 Alzheimer's disease; CESC trans rs11098499 0.954 rs6820115 chr4:120398182 T/C cg25214090 chr10:38739885 LOC399744 0.67 9.69 0.51 3.43e-19 Corneal astigmatism; CESC trans rs1945213 0.694 rs17149976 chr11:55839746 T/C cg03929089 chr4:120376271 NA 0.76 7.26 0.41 4.31e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs9287719 0.967 rs10191883 chr2:10744136 A/G cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs9291683 0.595 rs11722930 chr4:10035454 G/A cg11266682 chr4:10021025 SLC2A9 0.7 13.85 0.65 3.49e-33 Bone mineral density; CESC cis rs9300255 0.568 rs3018098 chr12:123654812 T/C cg19016782 chr12:123741754 C12orf65 -0.43 -6.15 -0.35 2.78e-9 Neutrophil percentage of white cells; CESC cis rs7692995 1.000 rs16896068 chr4:17944840 C/T cg08925142 chr4:18023851 LCORL -0.45 -5.3 -0.31 2.41e-7 Height; CESC cis rs9486719 0.947 rs9386648 chr6:97035656 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -8.21 -0.45 9.56e-15 Migraine;Coronary artery disease; CESC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg19717773 chr7:2847554 GNA12 -0.58 -8.34 -0.46 4.07e-15 Height; CESC cis rs11098499 0.865 rs2389809 chr4:120377399 T/C cg09307838 chr4:120376055 NA 0.96 13.95 0.65 1.6e-33 Corneal astigmatism; CESC cis rs9788682 0.747 rs7174190 chr15:78763617 C/T cg24631222 chr15:78858424 CHRNA5 0.61 7.16 0.4 8.13e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg11764359 chr7:65958608 NA -0.72 -9.26 -0.49 7.15e-18 Aortic root size; CESC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg17971929 chr21:40555470 PSMG1 1.04 16.4 0.71 3.34e-42 Cognitive function; CESC cis rs7666738 0.830 rs9992639 chr4:98940400 G/T cg17366294 chr4:99064904 C4orf37 0.61 8.59 0.47 7.44e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9811920 0.535 rs792837 chr3:99477182 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.33 -5.42 -0.32 1.37e-7 Axial length; CESC cis rs2243480 1.000 rs73142121 chr7:65311206 C/T cg18252515 chr7:66147081 NA -1.07 -10.29 -0.53 4.14e-21 Diabetic kidney disease; CESC cis rs7772486 0.713 rs1986729 chr6:146194831 G/A cg23711669 chr6:146136114 FBXO30 1.02 15.62 0.69 1.98e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.77 0.38 8.38e-11 Bipolar disorder; CESC cis rs3026101 0.671 rs56018748 chr17:5316939 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.22 0.31 3.62e-7 Body mass index; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09061759 chr1:65431709 JAK1 -0.49 -6.18 -0.35 2.4e-9 Ulcerative colitis; CESC cis rs61931739 0.517 rs11053067 chr12:34191391 T/C cg19457237 chr12:34500585 NA -0.39 -5.39 -0.31 1.53e-7 Morning vs. evening chronotype; CESC cis rs1707322 0.821 rs10749857 chr1:46248143 C/T cg06784218 chr1:46089804 CCDC17 0.34 5.82 0.34 1.67e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35146811 0.844 rs10281368 chr7:99655897 A/G cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.48 5.99 0.35 6.84e-9 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08328324 chr8:33370759 C8orf41 -0.55 -6.28 -0.36 1.38e-9 Gut microbiome composition (summer); CESC trans rs11764590 0.694 rs55860148 chr7:2105594 G/A cg11693508 chr17:37793320 STARD3 0.68 7.39 0.41 1.92e-12 Neuroticism; CESC trans rs7191820 0.539 rs9927057 chr16:79360803 A/G cg02396914 chr8:120743868 TAF2 -0.49 -6.37 -0.36 8.5e-10 Obesity-related traits; CESC cis rs7208859 0.623 rs609063 chr17:28951513 A/G cg14008862 chr17:28927542 LRRC37B2 0.75 5.53 0.32 7.72e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs796364 0.806 rs74724807 chr2:201005109 A/C cg23649088 chr2:200775458 C2orf69 -0.55 -5.04 -0.3 8.69e-7 Schizophrenia; CESC cis rs79057730 0.599 rs4721086 chr7:821123 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.72 6.55 0.37 2.98e-10 Initial pursuit acceleration; CESC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.92 9.76 0.51 2.07e-19 Platelet count; CESC cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -6.28 -0.36 1.37e-9 Mood instability; CESC cis rs1832871 0.683 rs56197409 chr6:158684338 A/G cg07165851 chr6:158734300 TULP4 0.6 6.34 0.36 9.88e-10 Height; CESC cis rs7666738 0.830 rs35560671 chr4:99069095 G/A cg03467027 chr4:99064603 C4orf37 0.48 5.96 0.34 7.81e-9 Colonoscopy-negative controls vs population controls; CESC cis rs561341 1.000 rs497479 chr17:30328605 C/T cg12193833 chr17:30244370 NA -0.67 -6.35 -0.36 9.44e-10 Hip circumference adjusted for BMI; CESC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg24675658 chr1:53192096 ZYG11B -0.59 -7.33 -0.41 2.83e-12 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00076056 chr16:85061228 KIAA0513 0.57 6.58 0.37 2.53e-10 Gut microbiome composition (summer); CESC cis rs1878931 0.507 rs4429296 chr16:3408277 T/G cg02880119 chr16:3481970 NA 0.4 5.2 0.3 3.91e-7 Body mass index (adult); CESC cis rs2315504 0.692 rs12602410 chr17:39017343 A/G cg05063374 chr17:38953512 KRT28 -0.38 -5.11 -0.3 6.06e-7 Height; CESC cis rs2290159 0.800 rs5746187 chr3:12659419 A/G cg23032965 chr3:12705835 RAF1 0.53 5.69 0.33 3.41e-8 Cholesterol, total; CESC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg17279839 chr7:150038598 RARRES2 0.43 5.34 0.31 2.03e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs78049276 0.568 rs10305839 chr4:148400413 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.64 -6.72 -0.38 1.11e-10 Pulse pressure; CESC cis rs4646450 0.636 rs2003499 chr7:99014984 A/G cg24650262 chr7:98904301 NA 0.43 5.05 0.3 8.34e-7 Blood metabolite levels; CESC cis rs113835537 0.529 rs11227502 chr11:66274148 T/G cg22134325 chr11:66188745 NPAS4 0.36 5.65 0.33 4.17e-8 Airway imaging phenotypes; CESC cis rs11048434 0.736 rs4309200 chr12:9121856 A/C cg23795048 chr12:9217529 LOC144571 0.33 5.05 0.3 8.2e-7 Sjögren's syndrome; CESC cis rs9840812 0.728 rs6439646 chr3:136273563 T/C cg15507776 chr3:136538369 TMEM22 0.42 5.07 0.3 7.46e-7 Fibrinogen levels; CESC cis rs9303401 0.703 rs9910629 chr17:57210301 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.59 7.67 0.43 3.29e-13 Cognitive test performance; CESC cis rs6964587 0.869 rs6964050 chr7:91482418 C/T cg17063962 chr7:91808500 NA -0.52 -6.98 -0.39 2.31e-11 Breast cancer; CESC cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg14784868 chr12:69753453 YEATS4 -0.75 -10.95 -0.56 2.88e-23 Blood protein levels; CESC cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg11890956 chr21:40555474 PSMG1 0.81 12.36 0.6 5.15e-28 Cognitive function; CESC cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 5.47 0.32 1.04e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1832871 0.655 rs4273715 chr6:158722847 T/C cg07165851 chr6:158734300 TULP4 0.61 6.77 0.38 8.06e-11 Height; CESC cis rs2637266 1.000 rs10219021 chr10:78364516 C/T cg18941641 chr10:78392320 NA 0.43 8.16 0.45 1.34e-14 Pulmonary function; CESC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg17971929 chr21:40555470 PSMG1 -0.85 -12.14 -0.6 2.84e-27 Cognitive function; CESC cis rs8058578 0.945 rs885107 chr16:30672719 T/C cg02466173 chr16:30829666 NA -0.4 -6.37 -0.36 8.16e-10 Multiple myeloma; CESC cis rs79839061 0.610 rs2306252 chr4:892116 T/C cg07828340 chr4:882639 GAK 0.83 7.07 0.4 1.41e-11 Intelligence (multi-trait analysis); CESC cis rs3780486 0.846 rs7864705 chr9:33140352 A/C cg13443165 chr9:33130375 B4GALT1 0.45 6.65 0.38 1.71e-10 IgG glycosylation; CESC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg06074448 chr4:187884817 NA -0.37 -5.44 -0.32 1.21e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs2066819 1.000 rs77768890 chr12:56725121 A/G cg26734620 chr12:56694298 CS 1.02 6.17 0.35 2.52e-9 Psoriasis vulgaris; CESC trans rs2727020 0.701 rs7949044 chr11:49597334 C/T cg15704280 chr7:45808275 SEPT13 -0.86 -11.62 -0.58 1.63e-25 Coronary artery disease; CESC cis rs5753037 0.564 rs131298 chr22:30180001 C/T cg01021169 chr22:30184971 ASCC2 0.56 8.47 0.46 1.69e-15 Type 1 diabetes; CESC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg23978390 chr7:1156363 C7orf50 0.59 6.04 0.35 5.26e-9 Bronchopulmonary dysplasia; CESC cis rs12369179 0.737 rs116896792 chr12:122948907 T/C cg18578876 chr12:123200353 GPR109B -0.93 -7.09 -0.4 1.19e-11 Age-related diseases, mortality and associated endophenotypes;Age-related disease endophenotypes; CESC cis rs6835098 1.000 rs9990666 chr4:174083150 G/T cg08422745 chr4:174089978 GALNT7 -0.82 -11.83 -0.59 3.26e-26 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs6732160 0.588 rs2043099 chr2:73374156 G/A cg01422370 chr2:73384389 NA 0.57 9.1 0.49 2.21e-17 Intelligence (multi-trait analysis); CESC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7937682 1.000 rs7121011 chr11:111568681 C/T cg22437258 chr11:111473054 SIK2 -0.68 -7.83 -0.43 1.19e-13 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07907564 chr7:73589340 EIF4H -0.57 -6.6 -0.38 2.28e-10 Gut microbiome composition (summer); CESC cis rs6460942 1.000 rs62448563 chr7:12400040 G/A cg17427002 chr7:12443146 VWDE -0.51 -5.05 -0.3 8.11e-7 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21755457 chr12:54020320 ATF7 -0.4 -6.01 -0.35 6.18e-9 Gambling; CESC cis rs8060686 0.668 rs9932414 chr16:68219969 A/G cg26727032 chr16:67993705 SLC12A4 -0.6 -8.91 -0.48 8.26e-17 HDL cholesterol;Metabolic syndrome; CESC cis rs1003719 0.688 rs2000413 chr21:38539718 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.77 -0.43 1.71e-13 Eye color traits; CESC cis rs2180341 0.814 rs6905553 chr6:127727407 A/G cg27446573 chr6:127587934 RNF146 0.83 12.03 0.59 6.99e-27 Breast cancer; CESC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg25405998 chr7:65216604 CCT6P1 0.43 5.53 0.32 7.54e-8 Calcium levels; CESC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.4 0.41 1.83e-12 Electroencephalogram traits; CESC cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.55 -0.42 6.87e-13 Alzheimer's disease; CESC cis rs7927771 0.524 rs754434 chr11:47814280 A/G cg20307385 chr11:47447363 PSMC3 0.62 8.62 0.47 6.37e-16 Subjective well-being; CESC cis rs4975616 0.804 rs457130 chr5:1336178 A/T cg07493874 chr5:1342172 CLPTM1L -0.42 -7.83 -0.43 1.21e-13 Lung cancer; CESC trans rs6600671 0.934 rs11249348 chr1:121188302 T/C cg17023122 chr1:144479586 NA 0.44 6.13 0.35 3.24e-9 Hip geometry; CESC cis rs6076065 0.748 rs4815198 chr20:23343491 T/C cg11657817 chr20:23433608 CST11 0.39 5.95 0.34 8.62e-9 Facial morphology (factor 15, philtrum width); CESC cis rs2519796 0.531 rs2519108 chr9:136807640 C/T cg13751417 chr9:136814406 VAV2 0.41 5.45 0.32 1.18e-7 Hematocrit;Hemoglobin concentration; CESC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg00484396 chr16:3507460 NAT15 -0.42 -6.91 -0.39 3.51e-11 Tuberculosis; CESC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg23161317 chr6:28129485 ZNF389 0.51 6.5 0.37 3.98e-10 Depression; CESC cis rs6456156 0.586 rs12529876 chr6:167461501 G/A cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.13e-10 Primary biliary cholangitis; CESC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg25838465 chr1:92012736 NA -0.61 -8.91 -0.48 8.65e-17 Breast cancer; CESC cis rs4911253 0.527 rs853859 chr20:31402269 A/G cg13636640 chr20:31349939 DNMT3B 0.7 9.98 0.52 4.17e-20 Lymphocyte counts; CESC cis rs6586111 0.647 rs2880655 chr10:82369816 G/T cg03086067 chr10:82368399 SH2D4B -0.36 -5.94 -0.34 8.82e-9 Capecitabine sensitivity; CESC cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg17143192 chr8:8559678 CLDN23 0.77 8.87 0.48 1.09e-16 Obesity-related traits; CESC cis rs9487051 0.768 rs427960 chr6:109524939 C/T cg01475377 chr6:109611718 NA -0.44 -6.62 -0.38 1.93e-10 Reticulocyte fraction of red cells; CESC cis rs57506017 0.540 rs7808568 chr7:12271252 T/C cg23422036 chr7:12250390 TMEM106B 0.39 5.24 0.31 3.21e-7 Neuroticism; CESC cis rs929354 0.742 rs7801905 chr7:156940111 T/C cg05182265 chr7:156933206 UBE3C -0.49 -7.03 -0.4 1.76e-11 Body mass index; CESC cis rs9467711 0.606 rs12174631 chr6:26373150 C/T cg14345882 chr6:26364793 BTN3A2 0.61 6.49 0.37 4.12e-10 Autism spectrum disorder or schizophrenia; CESC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg11764359 chr7:65958608 NA 0.96 15.21 0.68 5.32e-38 Aortic root size; CESC cis rs7927771 0.931 rs4752801 chr11:47907641 A/G cg18512352 chr11:47633146 NA -0.56 -9.14 -0.49 1.72e-17 Subjective well-being; CESC cis rs12477438 0.834 rs10179043 chr2:99687490 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.4 -0.54 1.79e-21 Chronic sinus infection; CESC trans rs6987853 0.830 rs2272685 chr8:42354102 C/T cg27650678 chr11:66636318 PC -0.46 -6.08 -0.35 4.13e-9 Mean corpuscular hemoglobin concentration; CESC cis rs2180341 0.889 rs2000909 chr6:127711173 G/A cg27446573 chr6:127587934 RNF146 0.81 11.43 0.57 7.46e-25 Breast cancer; CESC cis rs115056730 0.520 rs114113305 chr2:98189209 A/T cg26665480 chr2:98280029 ACTR1B -0.96 -6.66 -0.38 1.62e-10 Monocyte chemoattractant protein-3 levels; CESC cis rs7089973 0.604 rs35319791 chr10:116602296 C/A cg25233709 chr10:116636983 FAM160B1 0.38 6.08 0.35 4.13e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4595586 0.566 rs7307174 chr12:39368862 A/G cg26384229 chr12:38710491 ALG10B 0.43 6.1 0.35 3.82e-9 Morning vs. evening chronotype; CESC cis rs4308124 0.708 rs10178095 chr2:111972516 C/T cg04571233 chr2:111982156 NA -0.62 -6.8 -0.39 6.82e-11 Vitiligo; CESC cis rs2243480 1.000 rs383402 chr7:65586653 A/C cg13147721 chr7:65941812 NA 0.85 8.7 0.47 3.69e-16 Diabetic kidney disease; CESC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg11764359 chr7:65958608 NA 0.96 15.17 0.68 7.94e-38 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06136617 chr16:4027502 ADCY9 0.42 6.07 0.35 4.38e-9 Fibrinogen levels; CESC cis rs2404602 0.692 rs4383105 chr15:77055510 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs78456975 1.000 rs13431491 chr2:1553808 T/A cg01028140 chr2:1542097 TPO -0.5 -5.26 -0.31 3.03e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs5758511 0.633 rs5758690 chr22:42668295 C/G cg00645731 chr22:42541494 CYP2D7P1 0.57 8.5 0.46 1.37e-15 Birth weight; CESC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg23978390 chr7:1156363 C7orf50 0.54 7.14 0.4 9.19e-12 Longevity;Endometriosis; CESC cis rs7927592 0.830 rs7120635 chr11:68261293 A/G cg16797656 chr11:68205561 LRP5 0.41 6.2 0.36 2.16e-9 Total body bone mineral density; CESC trans rs5756813 0.635 rs12160750 chr22:38199054 A/G cg19894588 chr14:64061835 NA -0.68 -8.42 -0.46 2.36e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg12365402 chr11:9010492 NRIP3 0.37 5.68 0.33 3.49e-8 Hemoglobin concentration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08240007 chr2:220407822 CHPF;TMEM198 -0.39 -6.07 -0.35 4.48e-9 Gambling; CESC cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.33 5.21 0.3 3.79e-7 Personality dimensions; CESC cis rs72781680 0.898 rs12623316 chr2:24087857 A/G cg08917208 chr2:24149416 ATAD2B 0.91 8.36 0.46 3.7e-15 Lymphocyte counts; CESC cis rs2637266 0.626 rs2583066 chr10:78555839 T/C cg18941641 chr10:78392320 NA 0.41 7.79 0.43 1.51e-13 Pulmonary function; CESC cis rs3096299 0.967 rs2911253 chr16:89488587 T/G cg08822215 chr16:89438651 ANKRD11 -0.37 -5.72 -0.33 2.81e-8 Multiple myeloma (IgH translocation); CESC cis rs137699 0.687 rs4821887 chr22:39756985 C/T cg11247378 chr22:39784982 NA -0.5 -6.59 -0.38 2.4e-10 IgG glycosylation; CESC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10782582 0.593 rs6704444 chr1:76205108 T/C cg22875332 chr1:76189707 ACADM -0.47 -5.66 -0.33 3.93e-8 Daytime sleep phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14146092 chr11:129873378 NCRNA00167;PRDM10 -0.55 -6.4 -0.37 7.08e-10 Gut microbiome composition (summer); CESC cis rs9303280 0.836 rs11557467 chr17:38028634 G/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.54 -0.32 7.15e-8 Self-reported allergy; CESC cis rs4664293 0.967 rs12999124 chr2:160531328 A/G cg08347373 chr2:160653686 CD302 -0.33 -5.29 -0.31 2.5e-7 Monocyte percentage of white cells; CESC cis rs7809950 0.635 rs62483629 chr7:106866178 T/C cg23024343 chr7:107201750 COG5 -0.58 -6.95 -0.39 2.79e-11 Coronary artery disease; CESC cis rs8050907 0.590 rs11860985 chr16:4555965 G/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.8 5.38 0.31 1.61e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00502533 chr1:113498761 SLC16A1 -0.54 -6.36 -0.36 8.75e-10 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg13206674 chr6:150067644 NUP43 0.45 6.43 0.37 5.82e-10 Lung cancer; CESC cis rs9815354 1.000 rs1716644 chr3:41968028 A/G cg03022575 chr3:42003672 ULK4 -0.46 -5.37 -0.31 1.76e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs17818399 0.962 rs7565274 chr2:46841861 G/T cg02822958 chr2:46747628 ATP6V1E2 0.46 5.74 0.33 2.55e-8 Height; CESC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs10504073 0.584 rs17642664 chr8:49942945 A/G cg00325661 chr8:49890786 NA 0.58 8.67 0.47 4.37e-16 Blood metabolite ratios; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13820145 chr20:26062310 FAM182A -0.47 -6.19 -0.36 2.28e-9 Gut microbiome composition (summer); CESC cis rs2204008 0.580 rs36118148 chr12:38411812 G/A cg26384229 chr12:38710491 ALG10B -0.41 -5.49 -0.32 9.35e-8 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14981573 chr1:70671146 SFRS11;LRRC40 0.57 6.36 0.36 8.8e-10 Gut microbiome composition (summer); CESC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg07211511 chr3:129823064 LOC729375 -0.59 -7.28 -0.41 3.84e-12 Blood pressure (smoking interaction); CESC cis rs644799 0.544 rs1527450 chr11:95467777 G/T cg25478527 chr11:95522999 CEP57;FAM76B 0.41 5.21 0.3 3.83e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs938554 0.513 rs4529048 chr4:9997112 G/T cg00071950 chr4:10020882 SLC2A9 0.64 8.57 0.47 8.41e-16 Blood metabolite levels; CESC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Depression; CESC cis rs60154123 0.730 rs587203 chr1:210463786 C/T cg22029157 chr1:209979665 IRF6 0.47 5.87 0.34 1.3e-8 Coronary artery disease; CESC cis rs7917772 0.503 rs11191326 chr10:104302959 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.19 0.3 4.1e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6060717 0.536 rs3787173 chr20:34472105 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -6.93 -0.39 3.22e-11 Hip circumference adjusted for BMI; CESC trans rs7937682 0.889 rs2850247 chr11:111637202 C/A cg18187862 chr3:45730750 SACM1L -0.63 -7.83 -0.43 1.14e-13 Primary sclerosing cholangitis; CESC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg04369109 chr6:150039330 LATS1 -0.46 -6.46 -0.37 4.96e-10 Lung cancer; CESC cis rs9640161 0.830 rs13307276 chr7:150061525 T/C cg21361702 chr7:150065534 REPIN1 0.69 8.45 0.46 1.94e-15 Blood protein levels;Circulating chemerin levels; CESC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg08859206 chr1:53392774 SCP2 -0.63 -8.33 -0.46 4.29e-15 Monocyte count; CESC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.59 6.66 0.38 1.56e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.64 0.64 1.86e-32 Prudent dietary pattern; CESC cis rs3820928 0.874 rs59630650 chr2:227786514 T/C cg11843606 chr2:227700838 RHBDD1 -0.44 -5.84 -0.34 1.5e-8 Pulmonary function; CESC cis rs1215050 0.791 rs260902 chr4:98764694 G/A cg05340658 chr4:99064831 C4orf37 0.51 6.65 0.38 1.63e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1577917 1.000 rs12216203 chr6:86675301 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.05 -0.35 4.79e-9 Response to antipsychotic treatment; CESC cis rs66887589 0.592 rs2175383 chr4:120215836 C/A cg09307838 chr4:120376055 NA 0.67 9.37 0.5 3.4e-18 Diastolic blood pressure; CESC cis rs11583043 0.874 rs72734253 chr1:101380718 A/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 6.69 0.38 1.29e-10 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs703842 1.000 rs10877014 chr12:58167661 A/G cg18357645 chr12:58087776 OS9 -0.38 -5.33 -0.31 2.06e-7 Multiple sclerosis; CESC cis rs36051895 0.632 rs7040922 chr9:5174829 A/G cg02405213 chr9:5042618 JAK2 0.53 6.88 0.39 4.37e-11 Pediatric autoimmune diseases; CESC cis rs7223966 1.000 rs7209435 chr17:61712964 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.66 -0.33 3.84e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9486715 0.867 rs4438964 chr6:96917563 T/G cg06623918 chr6:96969491 KIAA0776 0.93 14.33 0.66 6.89e-35 Headache; CESC cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg10523679 chr1:76189770 ACADM 0.66 6.65 0.38 1.71e-10 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15470736 chr7:157056012 UBE3C -0.65 -7.63 -0.42 4.26e-13 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg23758822 chr17:41437982 NA 0.99 15.38 0.69 1.36e-38 Menopause (age at onset); CESC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg19046167 chr17:80928561 B3GNTL1 0.48 5.71 0.33 3.09e-8 Glycated hemoglobin levels; CESC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg09509183 chr1:209979624 IRF6 0.48 5.92 0.34 1.02e-8 Cleft lip with or without cleft palate; CESC cis rs2996428 0.667 rs16824230 chr1:3766240 A/G cg17848003 chr1:3704513 LRRC47 0.36 5.06 0.3 7.97e-7 Red cell distribution width; CESC cis rs7819412 0.745 rs2898260 chr8:10939490 G/T cg21775007 chr8:11205619 TDH -0.42 -6.18 -0.35 2.45e-9 Triglycerides; CESC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2297440 0.527 rs4809318 chr20:62264760 G/A cg06363034 chr20:62225388 GMEB2 -0.5 -6.3 -0.36 1.26e-9 Glioma;Non-glioblastoma glioma;Glioblastoma; CESC cis rs36051895 0.587 rs7848872 chr9:5197027 T/A cg02405213 chr9:5042618 JAK2 -0.51 -5.73 -0.33 2.77e-8 Pediatric autoimmune diseases; CESC cis rs832540 0.931 rs832399 chr5:56222358 A/T cg14703610 chr5:56206110 C5orf35 0.53 7.01 0.4 1.95e-11 Coronary artery disease; CESC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg22920501 chr2:26401640 FAM59B -0.91 -10.33 -0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs4604732 0.631 rs34330532 chr1:247626844 G/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9300255 0.739 rs1402275 chr12:123750895 A/G cg05973401 chr12:123451056 ABCB9 0.52 6.02 0.35 5.73e-9 Neutrophil percentage of white cells; CESC cis rs10911251 0.508 rs6424890 chr1:183112764 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.22 0.63 5.53e-31 Colorectal cancer; CESC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg07677032 chr17:61819896 STRADA 0.44 5.9 0.34 1.1e-8 Prudent dietary pattern; CESC cis rs425277 1.000 rs427811 chr1:2075560 T/G cg16545954 chr1:2118288 C1orf86 0.33 5.54 0.32 7.23e-8 Height; CESC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.44 0.37 5.62e-10 Bipolar disorder; CESC cis rs1843834 0.539 rs1494109 chr2:225441833 G/A cg22455342 chr2:225449267 CUL3 0.7 9.61 0.51 6.05e-19 IgE levels in asthmatics (D.p. specific); CESC cis rs72634258 0.554 rs34305100 chr1:7913029 A/G cg26816564 chr1:7831052 VAMP3 0.5 5.12 0.3 5.86e-7 Inflammatory bowel disease; CESC cis rs4423214 0.879 rs1792264 chr11:71150247 C/T cg05163923 chr11:71159392 DHCR7 -0.6 -7.02 -0.4 1.83e-11 Vitamin D levels; CESC cis rs7647973 1.000 rs10865956 chr3:49581559 C/A cg06212747 chr3:49208901 KLHDC8B 0.59 7.9 0.44 7.38e-14 Menarche (age at onset); CESC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg25405998 chr7:65216604 CCT6P1 0.45 5.19 0.3 4.22e-7 Aortic root size; CESC cis rs4975616 0.804 rs457130 chr5:1336178 A/T cg06550200 chr5:1325588 CLPTM1L -0.66 -9.89 -0.52 7.55e-20 Lung cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21055707 chr12:110486280 C12orf76 -0.44 -6.11 -0.35 3.6e-9 Gambling; CESC cis rs4700695 0.511 rs29443 chr5:65504927 G/A cg21114390 chr5:65439923 SFRS12 -0.47 -5.62 -0.33 4.75e-8 Facial morphology (factor 19); CESC cis rs3768617 0.510 rs2027075 chr1:183073266 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.5e-35 Fuchs's corneal dystrophy; CESC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg08704250 chr15:31115839 NA -0.68 -9.07 -0.49 2.76e-17 Huntington's disease progression; CESC cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg00825309 chr19:58991885 ZNF446 -0.53 -7.45 -0.42 1.29e-12 Uric acid clearance; CESC cis rs4843747 0.671 rs4075998 chr16:88106776 G/A cg06915872 chr16:87998081 BANP 0.44 5.24 0.31 3.36e-7 Menopause (age at onset); CESC cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg15017067 chr4:17643749 FAM184B 0.38 5.35 0.31 1.86e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs7088969 0.587 rs9888017 chr10:119553728 A/G cg11827998 chr14:105995685 TMEM121 -0.42 -6.13 -0.35 3.19e-9 Homeostasis model assessment of beta-cell function (dietary factor interaction); CESC cis rs290268 1.000 rs290271 chr9:93551619 G/A cg02608019 chr9:93564028 SYK 0.64 9.39 0.5 2.82e-18 Platelet count; CESC cis rs826838 1.000 rs1719830 chr12:39096992 T/G cg13010199 chr12:38710504 ALG10B -0.4 -5.54 -0.32 7.33e-8 Heart rate; CESC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg24829409 chr8:58192753 C8orf71 -0.69 -7.77 -0.43 1.77e-13 Developmental language disorder (linguistic errors); CESC cis rs644799 0.648 rs1255182 chr11:95472391 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.41 5.76 0.33 2.28e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs8114671 0.551 rs4911162 chr20:33411425 G/C cg24642439 chr20:33292090 TP53INP2 0.46 5.51 0.32 8.4e-8 Height; CESC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg14893161 chr1:205819251 PM20D1 -0.74 -12.71 -0.62 3.27e-29 Monocyte percentage of white cells; CESC cis rs1707322 0.717 rs3014245 chr1:46086913 C/T cg05343316 chr1:45956843 TESK2 -0.53 -6.5 -0.37 3.98e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4268898 1.000 rs6707781 chr2:24441883 T/G cg20701182 chr2:24300061 SF3B14 -0.43 -5.28 -0.31 2.67e-7 Asthma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24043861 chr14:73396628 DCAF4 -0.45 -6.13 -0.35 3.18e-9 Gut microbiota (bacterial taxa); CESC cis rs7296418 0.699 rs11057254 chr12:123794581 A/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.11 -0.3 6.27e-7 Platelet count; CESC cis rs6541297 1.000 rs1997947 chr1:230283764 A/G cg20703242 chr1:230279135 GALNT2 -0.68 -10.97 -0.56 2.42e-23 Coronary artery disease; CESC trans rs526821 0.553 rs519637 chr11:55295935 A/T cg15704280 chr7:45808275 SEPT13 -0.52 -6.37 -0.36 8.1e-10 Pediatric bone mineral density (spine); CESC trans rs61931739 0.817 rs304313 chr12:34216898 C/T cg26384229 chr12:38710491 ALG10B 0.5 6.83 0.39 5.7e-11 Morning vs. evening chronotype; CESC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg07395648 chr5:131743802 NA 0.41 5.35 0.31 1.86e-7 Breast cancer; CESC cis rs7264396 0.563 rs2425138 chr20:34345710 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.68 7.26 0.41 4.32e-12 Total cholesterol levels; CESC trans rs10411161 0.690 rs7252336 chr19:52389514 C/T cg22319618 chr22:45562946 NUP50 -0.76 -7.71 -0.43 2.6e-13 Breast cancer; CESC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 7.34 0.41 2.56e-12 Melanoma; CESC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg13206674 chr6:150067644 NUP43 0.45 6.47 0.37 4.82e-10 Lung cancer; CESC cis rs1538970 1.000 rs61791368 chr1:45867944 T/C cg24296786 chr1:45957014 TESK2 -0.44 -5.04 -0.3 8.63e-7 Platelet count; CESC cis rs1797885 0.564 rs2633443 chr3:12600837 G/A cg26432171 chr3:12704882 RAF1 -0.5 -6.61 -0.38 2.15e-10 Immature fraction of reticulocytes; CESC cis rs796364 0.755 rs6739563 chr2:201134216 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.57 5.2 0.3 3.92e-7 Schizophrenia; CESC cis rs61931739 0.500 rs10844845 chr12:34381117 C/T cg23762105 chr12:34175262 ALG10 -0.39 -5.05 -0.3 8.29e-7 Morning vs. evening chronotype; CESC cis rs9399135 0.935 rs11754504 chr6:135321509 C/T cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs7044106 0.762 rs966397 chr9:123453312 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.09 0.53 1.84e-20 Hip circumference adjusted for BMI; CESC cis rs2839186 0.605 rs2839173 chr21:47676711 G/A cg00815214 chr21:47717953 NA -0.36 -5.35 -0.31 1.91e-7 Testicular germ cell tumor; CESC cis rs4523957 0.786 rs216213 chr17:2134225 G/A cg16513277 chr17:2031491 SMG6 0.63 8.71 0.47 3.27e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9443189 0.615 rs6453829 chr6:76268509 C/T cg01950844 chr6:76311363 SENP6 0.87 9.17 0.49 1.36e-17 Prostate cancer; CESC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg04267008 chr7:1944627 MAD1L1 -0.49 -5.89 -0.34 1.19e-8 Schizophrenia; CESC trans rs61931739 0.500 rs7977194 chr12:34408459 G/A cg13010199 chr12:38710504 ALG10B 0.49 6.3 0.36 1.26e-9 Morning vs. evening chronotype; CESC cis rs1005277 0.505 rs200937 chr10:38135772 T/C cg00409905 chr10:38381863 ZNF37A -0.55 -7.6 -0.42 5.03e-13 Extrinsic epigenetic age acceleration; CESC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg19163074 chr7:65112434 INTS4L2 0.46 5.04 0.3 8.72e-7 Aortic root size; CESC cis rs7582720 1.000 rs72934737 chr2:203740798 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs897080 0.515 rs698763 chr2:44573624 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.66 0.33 3.83e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04095345 chr6:34857663 ANKS1A -0.57 -6.89 -0.39 4.07e-11 Gut microbiome composition (summer); CESC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg08392591 chr16:89556376 ANKRD11 0.56 7.59 0.42 5.32e-13 Multiple myeloma (IgH translocation); CESC cis rs10848704 0.637 rs11062351 chr12:2881763 C/T cg19995117 chr12:2880862 NA 0.57 9.66 0.51 4.08e-19 Quantitative traits; CESC cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg18099408 chr3:52552593 STAB1 -0.33 -5.19 -0.3 4.21e-7 Bipolar disorder; CESC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg10150615 chr22:24372951 LOC391322 0.6 8.0 0.44 3.97e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg26939375 chr7:64535504 NA 0.77 11.14 0.56 6.68e-24 Calcium levels; CESC cis rs4604732 0.642 rs4472786 chr1:247636518 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.43 0.32 1.26e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12479064 0.724 rs4851203 chr2:99986932 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.55 -6.64 -0.38 1.79e-10 Chronic sinus infection; CESC trans rs7985867 0.840 rs675945 chr13:26032877 G/A cg26929337 chr19:52511726 ZNF615 0.45 6.26 0.36 1.58e-9 Common carotid intima-media thickness; CESC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg06287003 chr12:125626642 AACS 0.33 5.28 0.31 2.74e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs10924970 0.649 rs12753233 chr1:235487094 C/T cg26050004 chr1:235667680 B3GALNT2 0.44 5.1 0.3 6.38e-7 Asthma; CESC cis rs858239 0.712 rs200717 chr7:23392271 A/G cg23682824 chr7:23144976 KLHL7 0.39 5.22 0.31 3.55e-7 Cerebrospinal fluid biomarker levels; CESC cis rs2985684 1.000 rs2985696 chr14:50094913 C/A cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.48 -5.56 -0.32 6.45e-8 Carotid intima media thickness; CESC cis rs76878669 0.561 rs2279861 chr11:66133336 A/G cg18002602 chr11:66138449 SLC29A2 0.4 6.62 0.38 1.93e-10 Educational attainment (years of education); CESC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs3820928 0.874 rs6718057 chr2:227834349 T/G cg11843606 chr2:227700838 RHBDD1 -0.45 -5.77 -0.33 2.22e-8 Pulmonary function; CESC cis rs4888262 0.604 rs12935075 chr16:74676033 A/T cg01733217 chr16:74700730 RFWD3 0.94 12.4 0.61 3.68e-28 Testicular germ cell tumor; CESC cis rs933688 1.000 rs12651840 chr5:90729592 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.17 16.18 0.7 2e-41 Smoking behavior; CESC cis rs897080 0.515 rs786403 chr2:44710788 G/A cg04920474 chr2:44395004 PPM1B 0.41 5.16 0.3 4.83e-7 Height; CESC cis rs11792861 0.926 rs1333344 chr9:111776224 C/T cg13535736 chr9:111863775 C9orf5 -0.44 -5.85 -0.34 1.48e-8 Menarche (age at onset); CESC cis rs2841277 0.676 rs4264326 chr14:105411700 A/G cg17340268 chr14:105411764 AHNAK2 -0.5 -6.7 -0.38 1.24e-10 Rheumatoid arthritis; CESC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8017423 0.900 rs7141887 chr14:90705364 G/T cg14092571 chr14:90743983 NA -0.58 -8.54 -0.46 1.04e-15 Mortality in heart failure; CESC cis rs710216 0.957 rs841563 chr1:43429520 C/T cg07803811 chr1:43423981 SLC2A1 0.47 5.04 0.3 8.75e-7 Red cell distribution width; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22467232 chr5:1816093 NDUFS6 -0.5 -6.84 -0.39 5.59e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs8114671 0.967 rs3746427 chr20:33730464 A/G cg24642439 chr20:33292090 TP53INP2 0.46 5.71 0.33 2.98e-8 Height; CESC cis rs2012796 0.956 rs10450940 chr14:81825326 C/A cg02996355 chr14:81879375 NA 0.5 5.86 0.34 1.34e-8 Night sleep phenotypes; CESC cis rs9916302 0.706 rs9893735 chr17:37469858 A/C cg07936489 chr17:37558343 FBXL20 0.92 10.37 0.54 2.23e-21 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04838709 chr14:21151782 ANG;RNASE4 -0.59 -6.98 -0.39 2.43e-11 Gut microbiome composition (summer); CESC cis rs478304 0.654 rs12289836 chr11:65436888 C/T cg27068330 chr11:65405492 SIPA1 0.43 5.33 0.31 2.12e-7 Acne (severe); CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg23131131 chr22:24373011 LOC391322 -0.63 -8.54 -0.46 1.06e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs826838 1.000 rs11183196 chr12:38685915 G/T cg13010199 chr12:38710504 ALG10B 0.62 8.78 0.47 2.05e-16 Heart rate; CESC cis rs1577917 1.000 rs10944163 chr6:86658693 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.29 -0.36 1.32e-9 Response to antipsychotic treatment; CESC cis rs950027 0.620 rs1145076 chr15:45684508 G/T cg21132104 chr15:45694354 SPATA5L1 0.65 8.35 0.46 3.84e-15 Response to fenofibrate (adiponectin levels); CESC cis rs798766 1.000 rs798762 chr4:1731150 T/C cg05874882 chr4:1763078 NA -0.61 -8.54 -0.46 1.07e-15 Bladder cancer;Urinary bladder cancer; CESC cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg19077165 chr18:44547161 KATNAL2 0.54 8.01 0.44 3.56e-14 Personality dimensions; CESC cis rs7582720 1.000 rs72934763 chr2:203758396 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs61931739 0.500 rs7137392 chr12:34447074 T/C cg23762105 chr12:34175262 ALG10 -0.4 -5.22 -0.31 3.7e-7 Morning vs. evening chronotype; CESC cis rs4523957 0.579 rs903160 chr17:2091765 C/T cg16513277 chr17:2031491 SMG6 -0.64 -8.92 -0.48 7.58e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00348771 chr1:165599927 MGST3 -0.46 -6.24 -0.36 1.68e-9 Asthma; CESC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg04317338 chr11:64019027 PLCB3 0.86 8.93 0.48 7.13e-17 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24771206 chr2:203735709 ICA1L 0.6 6.93 0.39 3.24e-11 Gut microbiome composition (summer); CESC cis rs4076764 0.958 rs11584957 chr1:163392937 C/T cg06092702 chr1:163392909 NA -0.42 -6.09 -0.35 4e-9 Motion sickness; CESC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs12249377 0.519 rs12259401 chr10:92594121 T/G cg14313238 chr10:92632228 RPP30 0.42 5.08 0.3 7.22e-7 White matter microstructure (global fractional anisotropy); CESC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg20891558 chr2:74357851 NA 0.82 12.12 0.6 3.38e-27 Gestational age at birth (maternal effect); CESC cis rs1499614 0.831 rs3800822 chr7:66147149 A/G cg12463550 chr7:65579703 CRCP -0.77 -6.0 -0.35 6.47e-9 Gout; CESC cis rs56161922 0.749 rs3738469 chr1:207818422 G/A cg09557387 chr1:207818395 CR1L 0.68 5.14 0.3 5.47e-7 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); CESC trans rs11098499 0.955 rs7685268 chr4:120162188 G/A cg25214090 chr10:38739885 LOC399744 0.64 8.53 0.46 1.16e-15 Corneal astigmatism; CESC cis rs6540559 0.673 rs1073150 chr1:210017083 G/A cg23283495 chr1:209979779 IRF6 0.48 5.61 0.33 5.1e-8 Cleft lip with or without cleft palate; CESC cis rs7618501 0.699 rs2681780 chr3:49897830 C/T cg24110177 chr3:50126178 RBM5 -0.45 -6.05 -0.35 5.01e-9 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13789711 chr9:139743225 PHPT1 0.49 6.43 0.37 5.89e-10 Gut microbiota (bacterial taxa); CESC cis rs763014 0.833 rs3743902 chr16:632728 T/C cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC cis rs10751667 0.643 rs7942693 chr11:957832 G/A cg06064525 chr11:970664 AP2A2 -0.48 -9.52 -0.5 1.15e-18 Alzheimer's disease (late onset); CESC cis rs79349575 0.749 rs12601672 chr17:47006493 T/C cg26022315 chr17:47021804 SNF8 0.38 5.11 0.3 6.3e-7 Type 2 diabetes; CESC cis rs55794721 0.509 rs909834 chr1:25757996 A/G cg03538708 chr1:25844672 NA -0.42 -6.21 -0.36 2.09e-9 Plateletcrit;Mean corpuscular volume; CESC trans rs4650994 0.525 rs2224811 chr1:178544323 C/T cg05059571 chr16:84539110 KIAA1609 0.39 6.01 0.35 5.99e-9 HDL cholesterol levels;HDL cholesterol; CESC cis rs1506636 0.646 rs805776 chr7:123212561 T/C cg03229431 chr7:123269106 ASB15 -0.42 -5.51 -0.32 8.34e-8 Plateletcrit;Platelet count; CESC cis rs4319547 0.737 rs7964138 chr12:122950375 A/G cg05707623 chr12:122985044 ZCCHC8 -0.56 -6.87 -0.39 4.45e-11 Body mass index; CESC cis rs10463316 0.894 rs6875014 chr5:150754345 C/T cg03212797 chr5:150827313 SLC36A1 -0.44 -5.64 -0.33 4.26e-8 Metabolite levels (Pyroglutamine); CESC cis rs6687430 0.532 rs2150038 chr1:10609973 G/T cg20482658 chr1:10539492 PEX14 0.42 8.9 0.48 9.19e-17 Hand grip strength; CESC cis rs8017423 0.838 rs11845950 chr14:90723962 T/A cg14092571 chr14:90743983 NA -0.55 -8.33 -0.46 4.53e-15 Mortality in heart failure; CESC cis rs1874326 0.545 rs4620232 chr7:138110210 A/G cg18008034 chr7:138118925 NA -0.41 -5.14 -0.3 5.34e-7 Quantitative traits; CESC cis rs9399137 0.561 rs11753985 chr6:135280438 C/T cg22676075 chr6:135203613 NA 0.54 7.01 0.4 2.04e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs10870270 1.000 rs4880263 chr10:133787629 C/T cg26149184 chr10:133730230 NA 0.4 5.42 0.32 1.35e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg00745463 chr17:30367425 LRRC37B -0.61 -5.86 -0.34 1.35e-8 Hip circumference adjusted for BMI; CESC cis rs7503807 1.000 rs901064 chr17:78596040 C/T cg09596252 chr17:78655493 RPTOR -0.52 -7.65 -0.43 3.84e-13 Obesity; CESC cis rs929354 0.772 rs10228145 chr7:157007337 A/G cg05182265 chr7:156933206 UBE3C -0.51 -7.45 -0.42 1.3e-12 Body mass index; CESC cis rs2777491 0.540 rs7164684 chr15:41705008 G/T cg02330683 chr15:41787940 ITPKA 0.42 5.03 0.3 9.14e-7 Ulcerative colitis; CESC cis rs5769707 0.967 rs739248 chr22:50025205 T/C cg20744362 chr22:50050164 C22orf34 0.46 8.05 0.44 2.79e-14 Monocyte count;Monocyte percentage of white cells; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg08555112 chr17:48942811 TOB1 0.45 6.05 0.35 5.02e-9 Weight; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24696268 chr4:49526636 NA -0.55 -6.84 -0.39 5.51e-11 Gut microbiome composition (summer); CESC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg11764359 chr7:65958608 NA -0.79 -9.51 -0.5 1.18e-18 Aortic root size; CESC cis rs4835473 0.932 rs2323190 chr4:144665435 C/T cg25736465 chr4:144833511 NA -0.35 -5.57 -0.32 6.16e-8 Immature fraction of reticulocytes; CESC cis rs1062177 0.855 rs1346489 chr5:151266534 C/T cg12924095 chr5:151150029 G3BP1 0.39 5.53 0.32 7.7e-8 Preschool internalizing problems; CESC cis rs7580658 0.963 rs4233583 chr2:128060068 C/A cg10021288 chr2:128175891 PROC -0.42 -6.62 -0.38 1.93e-10 Protein C levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26401633 chr14:73925225 NUMB -0.57 -6.71 -0.38 1.16e-10 Gut microbiome composition (summer); CESC cis rs5753618 0.561 rs4603880 chr22:31744721 T/C cg13145458 chr22:31556086 RNF185 -0.49 -5.52 -0.32 8.27e-8 Colorectal cancer; CESC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg24642844 chr7:1081250 C7orf50 -0.66 -8.28 -0.45 6.24e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7246657 0.943 rs9676967 chr19:37928089 G/C cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.69e-9 Coronary artery calcification; CESC cis rs9612 1.000 rs61002661 chr19:44269032 T/A cg08581076 chr19:44259116 C19orf61 0.48 5.69 0.33 3.4e-8 Exhaled nitric oxide output; CESC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12343791 chr22:39240109 NPTXR 0.59 6.57 0.37 2.58e-10 Gut microbiome composition (summer); CESC cis rs6500395 1.000 rs3743779 chr16:48574040 T/G cg04672837 chr16:48644449 N4BP1 0.49 6.08 0.35 4.18e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg26839252 chr6:160211577 TCP1;MRPL18 0.44 5.03 0.3 9.06e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg16405210 chr4:1374714 KIAA1530 0.75 10.47 0.54 1.09e-21 Obesity-related traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12598048 chr15:22892705 CYFIP1 -0.47 -6.77 -0.38 8.41e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7584330 0.704 rs7598954 chr2:238364776 C/T cg14458575 chr2:238380390 NA 0.89 11.72 0.58 7.74e-26 Prostate cancer; CESC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.96 11.05 0.56 1.32e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4555082 0.718 rs2816619 chr14:105732551 G/C cg13114125 chr14:105738426 BRF1 -0.9 -10.96 -0.56 2.66e-23 Mean platelet volume;Platelet distribution width; CESC cis rs3749237 0.615 rs55957735 chr3:49438158 G/A cg03060546 chr3:49711283 APEH 0.75 11.31 0.57 1.91e-24 Resting heart rate; CESC cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg08564027 chr20:61660810 NA -0.81 -12.9 -0.62 7.11e-30 Prostate cancer (SNP x SNP interaction); CESC cis rs67311347 0.869 rs7646899 chr3:40366982 A/G cg09455208 chr3:40491958 NA 0.48 7.97 0.44 4.61e-14 Renal cell carcinoma; CESC cis rs9486719 1.000 rs2179126 chr6:96871350 A/G cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs10751667 0.961 rs6597971 chr11:928598 T/A cg20946044 chr11:1010712 AP2A2 -0.42 -5.56 -0.32 6.59e-8 Alzheimer's disease (late onset); CESC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg18758796 chr5:131593413 PDLIM4 0.38 5.05 0.3 8.06e-7 Blood metabolite levels; CESC cis rs1707322 0.964 rs1707339 chr1:46513179 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.65 -0.33 4.08e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg07636037 chr3:49044803 WDR6 1.07 19.9 0.77 1.59e-54 Parkinson's disease; CESC cis rs10089 1.000 rs10061367 chr5:127449021 T/C cg19767477 chr5:127420684 SLC12A2 -0.41 -5.59 -0.32 5.76e-8 Ileal carcinoids; CESC cis rs2095921 1 rs2095921 chr1:11033322 C/G cg02454025 chr1:11042201 C1orf127 0.99 16.1 0.7 3.84e-41 Male-pattern baldness; CESC cis rs3796352 0.892 rs2581807 chr3:53088844 G/A cg07884673 chr3:53033167 SFMBT1 -0.64 -6.12 -0.35 3.42e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.78 0.38 7.94e-11 Bipolar disorder; CESC cis rs10779751 0.666 rs77270747 chr1:11214584 A/C cg08854313 chr1:11322531 MTOR -0.8 -10.59 -0.55 4.35e-22 Body mass index; CESC cis rs2540647 0.908 rs2540653 chr22:18973549 G/A cg12798833 chr22:18958832 DGCR5 0.61 6.45 0.37 5.38e-10 Blood metabolite ratios; CESC cis rs2204008 0.774 rs11520237 chr12:38266978 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.7 0.51 3.2e-19 Bladder cancer; CESC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg12311346 chr5:56204834 C5orf35 -0.46 -5.61 -0.33 5e-8 Coronary artery disease; CESC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg03647317 chr4:187891568 NA -0.39 -5.8 -0.34 1.88e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs4629180 1.000 rs13031791 chr2:102108790 T/C cg04415270 chr2:102091202 RFX8 0.46 7.46 0.42 1.25e-12 Chronic rhinosinusitis with nasal polyps; CESC cis rs10754283 0.967 rs1953821 chr1:90107098 C/G cg21401794 chr1:90099060 LRRC8C 0.63 8.14 0.45 1.52e-14 Amyotrophic lateral sclerosis (sporadic); CESC cis rs72781680 0.611 rs7602797 chr2:24318148 C/T cg08917208 chr2:24149416 ATAD2B 0.55 5.3 0.31 2.47e-7 Lymphocyte counts; CESC trans rs73191547 0.730 rs6601420 chr8:10045721 T/C cg11410023 chr3:96533511 EPHA6 -0.35 -6.0 -0.35 6.54e-9 Schizophrenia; CESC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg12143784 chr7:64541923 NA 0.41 5.43 0.32 1.3e-7 Calcium levels; CESC cis rs1215050 0.791 rs1506438 chr4:98789542 C/T cg05340658 chr4:99064831 C4orf37 0.52 6.86 0.39 4.98e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs12478296 1.000 rs12474070 chr2:243039738 C/T cg06360820 chr2:242988706 NA -0.66 -7.52 -0.42 8.51e-13 Obesity-related traits; CESC cis rs8049040 0.564 rs310335 chr16:71573918 T/A cg08717414 chr16:71523259 ZNF19 -0.59 -6.49 -0.37 4.11e-10 Blood protein levels; CESC cis rs6460942 0.915 rs17444141 chr7:12460971 T/G cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg23281280 chr6:28129359 ZNF389 -0.6 -8.58 -0.47 8.27e-16 Depression; CESC cis rs1670533 1.000 rs629260 chr4:1086764 A/G cg27284194 chr4:1044797 NA 0.48 6.17 0.35 2.6e-9 Recombination rate (females); CESC cis rs963731 0.649 rs297152 chr2:39326734 G/T cg04010122 chr2:39346883 SOS1 -0.61 -5.12 -0.3 6.01e-7 Corticobasal degeneration; CESC cis rs11122272 0.732 rs2808605 chr1:231540187 A/C cg06096015 chr1:231504339 EGLN1 0.42 6.05 0.35 4.97e-9 Hemoglobin concentration; CESC trans rs7746199 0.736 rs58616630 chr6:27474715 A/G cg06606381 chr12:133084897 FBRSL1 -1.1 -8.8 -0.48 1.75e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg03351412 chr1:154909251 PMVK 0.7 9.54 0.51 9.98e-19 Prostate cancer; CESC cis rs2290720 0.930 rs7298507 chr12:101715728 G/T cg22051763 chr12:101673672 UTP20 -0.49 -6.06 -0.35 4.55e-9 Brain structure (hippocampal volume); CESC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.61e-7 Life satisfaction; CESC cis rs2439831 0.867 rs2242068 chr15:43699304 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.92 10.28 0.53 4.31e-21 Lung cancer in ever smokers; CESC cis rs72634258 0.503 rs697675 chr1:7838113 A/C cg26816564 chr1:7831052 VAMP3 0.64 6.67 0.38 1.49e-10 Inflammatory bowel disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05989775 chr11:2906934 CDKN1C 0.45 6.34 0.36 1e-9 Gut microbiota (bacterial taxa); CESC trans rs6951245 0.529 rs76001997 chr7:1152615 C/T cg13565492 chr6:43139072 SRF -0.74 -8.88 -0.48 1.02e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11864453 1.000 rs11864453 chr16:72050480 C/T cg01557791 chr16:72042693 DHODH -0.67 -9.02 -0.48 3.92e-17 Fibrinogen levels; CESC cis rs6121246 0.821 rs3181073 chr20:30307199 A/C cg13852791 chr20:30311386 BCL2L1 -0.72 -7.79 -0.43 1.52e-13 Mean corpuscular hemoglobin; CESC cis rs7267979 1.000 rs6050561 chr20:25334855 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.13 -0.74 2.42e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs8072100 0.934 rs6504872 chr17:45438952 C/T cg08085267 chr17:45401833 C17orf57 -0.54 -7.43 -0.42 1.46e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1801251 0.893 rs11687128 chr2:233608901 T/C cg25237894 chr2:233734115 C2orf82 0.45 7.84 0.43 1.1e-13 Coronary artery disease; CESC cis rs1355223 1.000 rs11601205 chr11:34768479 C/T cg11058730 chr11:34937778 PDHX;APIP -0.43 -5.54 -0.32 7.34e-8 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg24531977 chr5:56204891 C5orf35 -0.98 -12.02 -0.59 7.7e-27 Initial pursuit acceleration; CESC trans rs8014252 0.667 rs10133282 chr14:70827899 C/A cg03123320 chr1:229394665 NA -0.49 -6.27 -0.36 1.45e-9 Plasma estrone levels in resected estrogen-receptor positive breast cancer; CESC cis rs7243790 0.967 rs62091589 chr18:51951697 G/C cg04730925 chr18:51795821 POLI -0.41 -5.36 -0.31 1.78e-7 Diastolic blood pressure; CESC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.97 0.52 4.38e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs9850225 0.719 rs4856616 chr3:80466481 A/C cg21058987 chr14:50778937 L2HGDH;ATP5S 0.38 6.12 0.35 3.42e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs10791323 0.572 rs10750551 chr11:133737462 G/A cg15485101 chr11:133734466 NA 0.37 6.19 0.36 2.32e-9 Childhood ear infection; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg24558718 chr10:853215 NA -0.48 -6.47 -0.37 4.75e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs3820928 0.874 rs10188770 chr2:227877037 G/A cg11843606 chr2:227700838 RHBDD1 -0.48 -6.13 -0.35 3.13e-9 Pulmonary function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04025889 chr20:32891089 AHCY 0.47 6.09 0.35 3.89e-9 Gut microbiota (bacterial taxa); CESC cis rs826838 0.904 rs1554550 chr12:39208889 G/A cg13010199 chr12:38710504 ALG10B 0.57 7.94 0.44 5.86e-14 Heart rate; CESC cis rs11630290 0.592 rs12232336 chr15:64153357 T/C cg12036633 chr15:63758958 NA 0.46 5.67 0.33 3.82e-8 Iris characteristics; CESC trans rs17783634 0.509 rs11775489 chr8:11036843 T/C cg06636001 chr8:8085503 FLJ10661 -0.54 -6.19 -0.36 2.22e-9 Subjective well-being; CESC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg14393609 chr7:65229607 NA -0.46 -6.16 -0.35 2.62e-9 Aortic root size; CESC cis rs9467711 0.606 rs9366653 chr6:26354247 G/A cg14345882 chr6:26364793 BTN3A2 0.6 6.29 0.36 1.33e-9 Autism spectrum disorder or schizophrenia; CESC cis rs11098499 0.687 rs71610270 chr4:120287436 A/G cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs7385804 0.796 rs221799 chr7:100288545 G/A cg16850897 chr7:100343110 ZAN 0.52 7.17 0.4 7.5e-12 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs9858542 1.000 rs2172252 chr3:49678307 A/T cg07274523 chr3:49395745 GPX1 0.65 8.2 0.45 1.03e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs3733585 0.683 rs13112015 chr4:9933796 C/T cg00071950 chr4:10020882 SLC2A9 -0.72 -12.57 -0.61 1e-28 Cleft plate (environmental tobacco smoke interaction); CESC cis rs698813 0.763 rs1067335 chr2:44625958 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.52 6.09 0.35 3.94e-9 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg14061069 chr19:46274453 DMPK -0.41 -5.56 -0.32 6.67e-8 Coronary artery disease; CESC trans rs1814175 0.645 rs10444311 chr11:49986906 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg23803603 chr1:2058230 PRKCZ -0.35 -5.85 -0.34 1.42e-8 Height; CESC cis rs60843830 1.000 rs3791224 chr2:221981 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.89 11.71 0.58 8.48e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg07677032 chr17:61819896 STRADA -0.45 -6.1 -0.35 3.8e-9 Prudent dietary pattern; CESC cis rs7216064 1.000 rs11870068 chr17:65944515 A/C cg12091567 chr17:66097778 LOC651250 -0.67 -6.79 -0.38 7.39e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10504073 0.584 rs4873300 chr8:49902201 C/G cg00325661 chr8:49890786 NA 0.55 8.31 0.45 5.1e-15 Blood metabolite ratios; CESC cis rs7247513 0.897 rs12979146 chr19:12717904 C/T cg01871581 chr19:12707946 ZNF490 -0.89 -15.22 -0.68 5.25e-38 Bipolar disorder; CESC cis rs2479106 0.591 rs16926721 chr9:126403335 G/C cg16191174 chr9:126692580 DENND1A 0.4 5.58 0.32 5.94e-8 Polycystic ovary syndrome; CESC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.92 -13.38 -0.64 1.5e-31 Prudent dietary pattern; CESC cis rs9549367 0.713 rs3024756 chr13:113822950 G/C cg18105134 chr13:113819100 PROZ -0.65 -8.24 -0.45 8.15e-15 Platelet distribution width; CESC cis rs3733585 0.699 rs7699609 chr4:9961059 A/G cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg16394138 chr1:180601363 XPR1 -0.49 -6.46 -0.37 4.97e-10 Height; CESC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg18305652 chr10:134549665 INPP5A 0.45 6.26 0.36 1.53e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs6934970 0.696 rs4945908 chr6:112996839 A/G cg05146922 chr2:10634174 NA -0.38 -6.03 -0.35 5.61e-9 Bipolar disorder (body mass index interaction); CESC cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg23422044 chr7:1970798 MAD1L1 -0.48 -5.22 -0.31 3.61e-7 Neuroticism; CESC cis rs4141404 0.640 rs9606854 chr22:31930567 C/T cg13145458 chr22:31556086 RNF185 -0.58 -6.26 -0.36 1.58e-9 Paclitaxel-induced neuropathy; CESC cis rs6901004 0.716 rs35312643 chr6:111574536 C/A cg15721981 chr6:111408429 SLC16A10 0.38 5.43 0.32 1.26e-7 Blood metabolite levels; CESC cis rs8070624 0.574 rs11078408 chr17:17876011 A/G cg16928487 chr17:17741425 SREBF1 -0.54 -8.64 -0.47 5.35e-16 Total body bone mineral density; CESC cis rs9875589 0.509 rs1601868 chr3:14065450 T/C cg19554555 chr3:13937349 NA -0.44 -5.6 -0.33 5.43e-8 Ovarian reserve; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06185204 chr15:80351985 ZFAND6 -0.67 -7.89 -0.44 8.09e-14 Gut microbiome composition (summer); CESC cis rs10504073 0.647 rs12549138 chr8:50007203 C/T cg00325661 chr8:49890786 NA 0.57 8.45 0.46 1.97e-15 Blood metabolite ratios; CESC cis rs7647973 0.600 rs12631989 chr3:49273996 C/T cg07636037 chr3:49044803 WDR6 0.8 13.11 0.63 1.37e-30 Menarche (age at onset); CESC cis rs910316 0.737 rs175499 chr14:75535927 G/A cg08847533 chr14:75593920 NEK9 -0.91 -15.78 -0.7 5.15e-40 Height; CESC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg04267008 chr7:1944627 MAD1L1 -0.61 -7.41 -0.41 1.71e-12 Bipolar disorder and schizophrenia; CESC cis rs2228479 0.681 rs4287569 chr16:89957815 A/G cg06558623 chr16:89946397 TCF25 0.57 5.7 0.33 3.26e-8 Skin colour saturation; CESC cis rs10504229 0.906 rs7846666 chr8:58172302 T/C cg05313129 chr8:58192883 C8orf71 -0.45 -5.6 -0.33 5.3e-8 Developmental language disorder (linguistic errors); CESC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg11764359 chr7:65958608 NA 0.73 10.6 0.55 4.14e-22 Aortic root size; CESC trans rs7672847 0.547 rs61651883 chr4:170460665 T/C cg19308436 chr1:237949471 RYR2 0.63 6.82 0.39 6.26e-11 Subjective well-being; CESC cis rs4819052 0.679 rs2838860 chr21:46684904 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 12.94 0.62 5.1e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8067545 0.611 rs2526482 chr17:20119133 C/T cg13482628 chr17:19912719 NA -0.43 -5.82 -0.34 1.66e-8 Schizophrenia; CESC cis rs7586879 1.000 rs7608185 chr2:25115432 G/C cg01884057 chr2:25150051 NA 0.28 5.12 0.3 5.86e-7 Body mass index; CESC cis rs12142240 0.667 rs12062 chr1:46830447 G/T cg10495392 chr1:46806563 NSUN4 -0.57 -6.18 -0.35 2.44e-9 Menopause (age at onset); CESC cis rs2797160 0.967 rs1578793 chr6:126015057 A/G cg05901451 chr6:126070800 HEY2 0.46 6.55 0.37 2.89e-10 Endometrial cancer; CESC cis rs9911578 0.967 rs72628392 chr17:56506160 A/G cg05425664 chr17:57184151 TRIM37 0.48 6.73 0.38 1.06e-10 Intelligence (multi-trait analysis); CESC cis rs950173 1.000 rs6716901 chr2:172673453 C/T cg13550731 chr2:172543902 DYNC1I2 -0.66 -5.12 -0.3 5.83e-7 Hippocampal volume; CESC cis rs6460942 1.000 rs7808819 chr7:12297440 C/T cg10578991 chr7:12443926 VWDE -0.56 -5.78 -0.33 2.08e-8 Coronary artery disease; CESC cis rs7220401 0.515 rs8080772 chr17:28413129 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.64 -6.77 -0.38 8.1e-11 Coronary artery disease; CESC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg12463550 chr7:65579703 CRCP -0.5 -6.29 -0.36 1.3e-9 Aortic root size; CESC cis rs6032067 0.777 rs55767422 chr20:43802497 A/G cg10761708 chr20:43804764 PI3 0.56 6.65 0.38 1.7e-10 Blood protein levels; CESC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.29 0.45 5.55e-15 Menopause (age at onset); CESC cis rs911555 0.713 rs10162425 chr14:103931621 C/T cg24130564 chr14:104152367 KLC1 -0.5 -6.66 -0.38 1.55e-10 Intelligence (multi-trait analysis); CESC cis rs9915657 0.595 rs10438697 chr17:70055734 A/G cg09344028 chr17:70110421 NA -0.38 -6.84 -0.39 5.5e-11 Thyroid hormone levels; CESC cis rs763014 0.931 rs710925 chr16:633354 G/A cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg12310025 chr6:25882481 NA -0.43 -6.22 -0.36 1.95e-9 Intelligence (multi-trait analysis); CESC cis rs7818345 1.000 rs4618712 chr8:19302621 A/G cg11303988 chr8:19266685 CSGALNACT1 0.33 6.0 0.35 6.57e-9 Language performance in older adults (adjusted for episodic memory); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11461836 chr5:176739316 MXD3 -0.47 -6.1 -0.35 3.68e-9 Asthma; CESC cis rs7829975 0.593 rs2979241 chr8:8303353 G/C cg15556689 chr8:8085844 FLJ10661 0.61 8.1 0.45 2.05e-14 Mood instability; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08017189 chr16:85680248 KIAA0182 0.44 6.46 0.37 4.93e-10 Fibrinogen levels; CESC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg13206674 chr6:150067644 NUP43 0.46 6.59 0.38 2.43e-10 Lung cancer; CESC cis rs60843830 1.000 rs36216559 chr2:262335 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.89 12.23 0.6 1.41e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7818688 1.000 rs10092003 chr8:96036422 A/G cg16049864 chr8:95962084 TP53INP1 0.61 5.77 0.33 2.24e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00320159 chr20:48429251 SLC9A8 0.56 6.0 0.35 6.35e-9 Gut microbiome composition (summer); CESC cis rs4718428 0.705 rs28648401 chr7:66367132 T/C cg25985355 chr7:65971099 NA -0.34 -5.12 -0.3 5.99e-7 Corneal structure; CESC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg13206674 chr6:150067644 NUP43 0.41 5.76 0.33 2.36e-8 Lung cancer; CESC cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg04455712 chr21:45112962 RRP1B 0.47 7.73 0.43 2.3e-13 Mean corpuscular volume; CESC cis rs7914558 0.966 rs7085598 chr10:104650128 T/C cg04362960 chr10:104952993 NT5C2 0.46 5.99 0.35 6.65e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg00166722 chr3:10149974 C3orf24 0.45 5.84 0.34 1.54e-8 Alzheimer's disease; CESC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg18225595 chr11:63971243 STIP1 0.74 10.32 0.54 3.36e-21 Platelet count; CESC cis rs4727027 0.865 rs13236754 chr7:148845773 G/A cg23583168 chr7:148888333 NA -0.81 -12.65 -0.61 5.11e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2046867 0.774 rs9820293 chr3:72876237 T/A cg25664220 chr3:72788482 NA -0.4 -5.68 -0.33 3.52e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs7584330 0.737 rs6431539 chr2:238360708 G/T cg14458575 chr2:238380390 NA 0.55 7.52 0.42 8.53e-13 Prostate cancer; CESC cis rs12579753 0.879 rs11115010 chr12:82165895 G/T cg24719984 chr12:82153464 PPFIA2 -0.37 -5.35 -0.31 1.9e-7 Resting heart rate; CESC cis rs2439831 0.867 rs2614811 chr15:43913487 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.8 8.31 0.45 5.16e-15 Lung cancer in ever smokers; CESC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg12193833 chr17:30244370 NA -0.6 -6.36 -0.36 8.68e-10 Hip circumference adjusted for BMI; CESC cis rs7208859 0.623 rs8075341 chr17:29136565 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC cis rs1707322 1.000 rs9793167 chr1:46446800 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7909791 0.632 rs3752949 chr10:105670503 A/G cg24587175 chr10:105670608 OBFC1 0.43 6.03 0.35 5.44e-9 White matter hyperintensity burden; CESC cis rs7178572 1.000 rs8034133 chr15:77763712 C/G cg22256960 chr15:77711686 NA -0.59 -7.96 -0.44 5e-14 Type 2 diabetes; CESC trans rs1814175 0.645 rs1963215 chr11:49931486 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22541143 chr4:84377292 HELQ;MRPS18C 0.45 6.29 0.36 1.3e-9 Gut microbiota (bacterial taxa); CESC cis rs77741769 0.529 rs2047568 chr12:121243790 A/G cg02419362 chr12:121203948 SPPL3 -0.33 -5.35 -0.31 1.89e-7 Mean corpuscular volume; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg03209809 chr3:126422892 CHCHD6 -0.44 -6.5 -0.37 3.93e-10 Vertical cup-disc ratio; CESC cis rs10779751 0.734 rs2748877 chr1:11129437 T/C cg08854313 chr1:11322531 MTOR 0.76 10.26 0.53 4.97e-21 Body mass index; CESC cis rs4704187 0.617 rs2035192 chr5:74407231 T/A cg03227963 chr5:74354835 NA 0.32 5.94 0.34 8.7e-9 Response to amphetamines; CESC cis rs7107174 1.000 rs11237462 chr11:78058812 C/A cg02023728 chr11:77925099 USP35 0.47 6.25 0.36 1.63e-9 Testicular germ cell tumor; CESC cis rs708547 0.874 rs1718869 chr4:57880232 A/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.69 7.8 0.43 1.45e-13 Response to bleomycin (chromatid breaks); CESC cis rs7786808 0.707 rs11770299 chr7:158228822 G/A cg09998033 chr7:158218633 PTPRN2 -0.43 -6.48 -0.37 4.46e-10 Obesity-related traits; CESC cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg25019033 chr10:957182 NA -0.66 -8.22 -0.45 8.89e-15 Eosinophil percentage of granulocytes; CESC cis rs593982 0.858 rs663797 chr11:65552740 A/G cg08755490 chr11:65554678 OVOL1 1.35 19.68 0.77 9.23e-54 Atopic dermatitis; CESC cis rs3733585 0.673 rs6836706 chr4:9964251 T/A cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs72781680 0.611 rs72783605 chr2:24287864 A/G cg06627628 chr2:24431161 ITSN2 -0.67 -6.42 -0.37 6.35e-10 Lymphocyte counts; CESC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg23172400 chr8:95962367 TP53INP1 -0.44 -9.11 -0.49 2.05e-17 Type 2 diabetes; CESC cis rs2066819 1.000 rs116849218 chr12:56683975 C/T cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs6582630 0.555 rs7965311 chr12:38513307 G/A cg13010199 chr12:38710504 ALG10B -0.43 -5.56 -0.32 6.5e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs116095464 0.614 rs10067482 chr5:219328 T/G cg22857025 chr5:266934 NA -1.27 -18.89 -0.76 5.51e-51 Breast cancer; CESC cis rs796364 0.951 rs12620298 chr2:201047184 C/T cg23649088 chr2:200775458 C2orf69 -0.55 -5.41 -0.32 1.39e-7 Schizophrenia; CESC cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg12463550 chr7:65579703 CRCP 0.67 5.38 0.31 1.67e-7 Diabetic kidney disease; CESC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg23161317 chr6:28129485 ZNF389 0.46 5.41 0.32 1.42e-7 Parkinson's disease; CESC cis rs7520050 0.966 rs1707340 chr1:46514942 T/C cg03146154 chr1:46216737 IPP -0.44 -5.72 -0.33 2.88e-8 Red blood cell count;Reticulocyte count; CESC trans rs79976124 0.837 rs12201218 chr6:66653619 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.71 -8.49 -0.46 1.47e-15 Type 2 diabetes; CESC cis rs868036 0.645 rs4776987 chr15:68123915 A/T cg08079166 chr15:68083412 MAP2K5 -0.4 -5.23 -0.31 3.39e-7 Restless legs syndrome; CESC cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg13628971 chr7:2884303 GNA12 0.4 5.06 0.3 8.02e-7 Height; CESC trans rs61931739 0.500 rs10844862 chr12:34531965 A/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 8.03e-13 Morning vs. evening chronotype; CESC cis rs7726839 0.540 rs58599998 chr5:596087 A/G cg16447950 chr5:562315 NA -0.59 -6.01 -0.35 6.18e-9 Obesity-related traits; CESC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg21963583 chr11:68658836 MRPL21 0.38 5.39 0.31 1.55e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11098499 0.954 rs7437420 chr4:120312903 A/G cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg05025164 chr4:1340916 KIAA1530 -0.65 -8.89 -0.48 9.35e-17 Obesity-related traits; CESC cis rs3760982 0.565 rs3786956 chr19:44286829 C/T cg11993925 chr19:44307056 LYPD5 0.44 7.46 0.42 1.26e-12 Breast cancer (estrogen-receptor negative);Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08493338 chr16:354269 AXIN1 -0.63 -7.08 -0.4 1.32e-11 Gut microbiome composition (summer); CESC cis rs3741404 0.609 rs687581 chr11:63871533 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.71 -9.97 -0.52 4.4e-20 Platelet count; CESC cis rs35955747 0.838 rs5997887 chr22:31543197 G/A cg25791279 chr22:32026902 PISD -0.43 -5.17 -0.3 4.66e-7 Neutrophil count;Sum basophil neutrophil counts; CESC trans rs961253 0.899 rs654433 chr20:6380022 A/G cg14636113 chr2:240742128 NA -0.46 -6.08 -0.35 4.28e-9 Colorectal cancer; CESC cis rs1153858 1.000 rs1365610 chr15:45694610 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 5.88 0.34 1.22e-8 Homoarginine levels; CESC trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21582582 chr3:182698605 DCUN1D1 -0.44 -6.01 -0.35 6.2e-9 Intelligence (multi-trait analysis); CESC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.74 7.36 0.41 2.29e-12 Platelet count; CESC cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg05535760 chr7:792225 HEATR2 0.91 10.41 0.54 1.64e-21 Cerebrospinal P-tau181p levels; CESC trans rs12310956 0.532 rs11052920 chr12:33955891 T/G cg26384229 chr12:38710491 ALG10B 0.45 6.39 0.37 7.33e-10 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07832761 chr16:15188255 RRN3 -0.44 -6.47 -0.37 4.61e-10 Gambling; CESC cis rs11785693 0.862 rs6994323 chr8:4996786 T/A cg26367366 chr8:4980734 NA 0.83 7.83 0.43 1.16e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs2997447 0.688 rs3008431 chr1:26371281 A/G cg19633962 chr1:26362018 EXTL1 -0.54 -5.49 -0.32 9.45e-8 QRS complex (12-leadsum); CESC cis rs9987353 0.544 rs2929469 chr8:9062656 T/G cg15556689 chr8:8085844 FLJ10661 0.47 5.52 0.32 8.21e-8 Recombination measurement; CESC cis rs10129255 0.500 rs9324092 chr14:107139823 A/G cg07470598 chr14:107239068 NA -0.36 -5.06 -0.3 7.74e-7 Kawasaki disease; CESC cis rs734999 0.545 rs4648356 chr1:2709164 C/A cg18854424 chr1:2615690 NA 0.3 5.78 0.33 2.12e-8 Ulcerative colitis; CESC cis rs6120849 0.950 rs6088732 chr20:33744134 A/G cg24642439 chr20:33292090 TP53INP2 -0.63 -6.89 -0.39 4.16e-11 Protein C levels; CESC cis rs6964587 1.000 rs55745934 chr7:91670998 T/C cg17063962 chr7:91808500 NA 0.55 7.47 0.42 1.19e-12 Breast cancer; CESC cis rs10242455 0.717 rs2687134 chr7:99331042 T/G cg07715041 chr7:99302981 CYP3A7 -0.49 -5.86 -0.34 1.34e-8 Blood metabolite levels; CESC cis rs10870270 0.957 rs3753008 chr10:133785129 A/C cg08754478 chr10:133766260 PPP2R2D -0.58 -7.62 -0.42 4.62e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs12822507 0.732 rs7132530 chr12:12753950 T/C cg11838227 chr12:12764436 CREBL2 0.42 5.61 0.33 5.15e-8 Systemic lupus erythematosus; CESC cis rs9287719 0.967 rs6733416 chr2:10738684 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg11494091 chr17:61959527 GH2 0.74 12.76 0.62 2.2e-29 Prudent dietary pattern; CESC cis rs1552244 0.882 rs13100734 chr3:10022878 A/G cg08888203 chr3:10149979 C3orf24 0.5 6.18 0.35 2.44e-9 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02277511 chr5:174905420 SFXN1 -0.48 -6.56 -0.37 2.82e-10 Fibrinogen levels; CESC cis rs1707322 0.752 rs11211146 chr1:46109794 T/C cg05343316 chr1:45956843 TESK2 0.5 6.18 0.35 2.46e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11190604 1.000 rs11190570 chr10:102227702 G/C cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7394190 0.748 rs11000780 chr10:75559077 G/A cg07699608 chr10:75541558 CHCHD1 0.65 5.31 0.31 2.31e-7 Incident atrial fibrillation; CESC cis rs9291683 0.632 rs7679916 chr4:10042160 C/T cg02734326 chr4:10020555 SLC2A9 0.47 6.53 0.37 3.29e-10 Bone mineral density; CESC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg04518342 chr5:131593106 PDLIM4 0.36 5.22 0.31 3.57e-7 Breast cancer; CESC cis rs4663969 0.733 rs6741669 chr2:234653192 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.49 -6.37 -0.36 8.39e-10 Total bilirubin levels in HIV-1 infection; CESC cis rs11785400 0.793 rs13248524 chr8:143739343 T/C cg10596483 chr8:143751796 JRK 0.42 5.31 0.31 2.32e-7 Schizophrenia; CESC cis rs7223966 1.000 rs8075521 chr17:61804954 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.68 0.38 1.4e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg03709012 chr19:19516395 GATAD2A 0.95 13.92 0.65 1.91e-33 Tonsillectomy; CESC cis rs1008375 1.000 rs55939327 chr4:17642937 T/A cg15017067 chr4:17643749 FAM184B 0.35 5.07 0.3 7.59e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7927592 0.871 rs55953412 chr11:68328283 C/T cg20283391 chr11:68216788 NA -0.61 -7.36 -0.41 2.26e-12 Total body bone mineral density; CESC cis rs7575873 1 rs7575873 chr2:23962647 A/G cg20701182 chr2:24300061 SF3B14 0.78 6.7 0.38 1.22e-10 Birth weight; CESC cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg25809561 chr17:30822961 MYO1D 0.54 8.4 0.46 2.83e-15 Schizophrenia; CESC cis rs6754311 0.773 rs1435576 chr2:136641882 A/T cg07169764 chr2:136633963 MCM6 0.7 8.66 0.47 4.59e-16 Mosquito bite size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25461793 chr19:17212553 MYO9B 0.52 6.73 0.38 1.06e-10 Fibrinogen levels; CESC cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg05585544 chr11:47624801 NA -0.52 -8.03 -0.44 3.23e-14 Subjective well-being; CESC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.84 8.38 0.46 3.05e-15 Platelet count; CESC cis rs1707322 1.000 rs6657720 chr1:46386269 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7146395 1 rs7146395 chr14:75228647 A/C cg08847533 chr14:75593920 NEK9 0.48 5.88 0.34 1.25e-8 Platelet count; CESC cis rs7772486 0.686 rs4896828 chr6:145953339 A/C cg05347473 chr6:146136440 FBXO30 0.56 7.24 0.41 4.97e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7814319 0.674 rs2643339 chr8:97246978 C/A cg20787634 chr8:97240163 UQCRB -0.5 -5.86 -0.34 1.36e-8 Lung function (FVC); CESC cis rs6598955 0.543 rs881578 chr1:26536141 G/A cg04990556 chr1:26633338 UBXN11 0.81 9.3 0.5 5.64e-18 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09998632 chr17:46688433 HOXB7 0.55 6.05 0.35 4.99e-9 Gut microbiome composition (summer); CESC cis rs589448 0.902 rs528974 chr12:69765918 A/T cg22834771 chr12:69754056 YEATS4 -0.57 -7.68 -0.43 3.15e-13 Cerebrospinal fluid biomarker levels; CESC cis rs2425143 0.915 rs74355238 chr20:34441541 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.78 -7.46 -0.42 1.25e-12 Blood protein levels; CESC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg26839252 chr6:160211577 TCP1;MRPL18 0.48 6.01 0.35 6.04e-9 Age-related macular degeneration (geographic atrophy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02196458 chr15:90809250 NGRN -0.45 -6.47 -0.37 4.68e-10 Gambling; CESC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg27125505 chr17:43679177 LOC644172 -0.48 -6.69 -0.38 1.34e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg12826209 chr6:26865740 GUSBL1 0.73 8.13 0.45 1.7e-14 Intelligence (multi-trait analysis); CESC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 11.71 0.58 8.43e-26 Platelet count; CESC cis rs2559856 1.000 rs2559855 chr12:102090080 A/G cg00136105 chr12:102224911 GNPTAB 0.37 5.04 0.3 8.7e-7 Blood protein levels; CESC cis rs1879734 0.731 rs4927028 chr1:54161545 T/C cg23596471 chr1:54105337 GLIS1 0.35 5.56 0.32 6.52e-8 Mitral valve prolapse; CESC cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg00475322 chr7:917719 C7orf20 0.46 5.1 0.3 6.53e-7 Cerebrospinal P-tau181p levels; CESC cis rs7089973 0.668 rs7898347 chr10:116644324 G/A cg23260525 chr10:116636907 FAM160B1 0.37 6.65 0.38 1.68e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1499972 0.938 rs817500 chr3:117713444 G/T cg07612923 chr3:117604196 NA 0.75 5.15 0.3 5.13e-7 Schizophrenia; CESC cis rs17376456 0.597 rs7708175 chr5:93381182 A/G cg25358565 chr5:93447407 FAM172A -0.47 -5.47 -0.32 1.03e-7 Diabetic retinopathy; CESC cis rs12477438 0.798 rs13412764 chr2:99583733 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.51 -0.54 7.92e-22 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01688026 chr15:83735344 BTBD1 0.57 6.47 0.37 4.72e-10 Gut microbiome composition (summer); CESC cis rs796364 1.000 rs35594306 chr2:200775125 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.95 -7.49 -0.42 1.06e-12 Schizophrenia; CESC trans rs4950322 0.518 rs4950306 chr1:146589420 C/G cg04954894 chr8:38089920 DDHD2 -0.59 -6.34 -0.36 9.74e-10 Protein quantitative trait loci; CESC cis rs3771570 1.000 rs55645375 chr2:242269024 A/G cg21155796 chr2:242212141 HDLBP 0.6 5.11 0.3 6.17e-7 Prostate cancer; CESC cis rs6545883 0.929 rs2694625 chr2:61616055 G/A cg15711740 chr2:61764176 XPO1 0.4 5.15 0.3 5.02e-7 Tuberculosis; CESC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg00149659 chr3:10157352 C3orf10 0.69 8.2 0.45 1.02e-14 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14557232 chr4:1368966 KIAA1530 -0.61 -6.96 -0.39 2.75e-11 Gut microbiome composition (summer); CESC cis rs6570726 1.000 rs450076 chr6:145847655 G/T cg05347473 chr6:146136440 FBXO30 0.42 5.68 0.33 3.58e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg12193833 chr17:30244370 NA -0.7 -6.49 -0.37 4.19e-10 Hip circumference adjusted for BMI; CESC cis rs2243480 1.000 rs1499614 chr7:65730798 A/T cg18252515 chr7:66147081 NA -1.36 -13.88 -0.65 2.66e-33 Diabetic kidney disease; CESC cis rs909002 0.772 rs10798876 chr1:32074514 C/G cg13919466 chr1:32135498 COL16A1 -0.47 -8.52 -0.46 1.24e-15 Intelligence (multi-trait analysis); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg17598323 chr1:44440401 ATP6V0B -0.47 -6.39 -0.37 7.44e-10 Recombination measurement; CESC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg18337363 chr3:52569053 NT5DC2 -0.29 -5.37 -0.31 1.68e-7 Bipolar disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20382160 chr11:75526115 UVRAG -0.49 -6.06 -0.35 4.62e-9 Asthma; CESC cis rs950776 0.507 rs12912673 chr15:78810216 T/C cg06917634 chr15:78832804 PSMA4 0.78 11.39 0.57 9.64e-25 Sudden cardiac arrest; CESC cis rs12995491 0.843 rs1878809 chr2:88518315 C/T cg18490616 chr2:88469792 THNSL2 -0.53 -7.53 -0.42 7.76e-13 Response to metformin (IC50); CESC cis rs2011503 1.000 rs56280531 chr19:19585788 A/C cg11584989 chr19:19387371 SF4 0.62 7.22 0.41 5.54e-12 Bipolar disorder; CESC cis rs61931739 0.517 rs10844830 chr12:34308133 C/T cg19457237 chr12:34500585 NA -0.38 -5.4 -0.31 1.52e-7 Morning vs. evening chronotype; CESC cis rs1953600 0.870 rs2573353 chr10:81940917 A/C cg00277334 chr10:82204260 NA -0.43 -5.93 -0.34 9.33e-9 Sarcoidosis; CESC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 9.59 0.51 6.99e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1577917 1.000 rs12663690 chr6:86640162 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.47 6.0 0.35 6.46e-9 Response to antipsychotic treatment; CESC trans rs116095464 0.558 rs6866632 chr5:264429 C/G cg00938859 chr5:1591904 SDHAP3 0.64 6.48 0.37 4.47e-10 Breast cancer; CESC cis rs17818399 0.749 rs4142759 chr2:46783890 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.49 -5.37 -0.31 1.76e-7 Height; CESC cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.835 rs67634087 chr17:80118168 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.42 -0.37 6.33e-10 Life satisfaction; CESC cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg24110177 chr3:50126178 RBM5 0.59 8.17 0.45 1.31e-14 Body mass index; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg24054508 chr1:38273761 C1orf122;YRDC 0.45 6.17 0.35 2.53e-9 Myopia (pathological); CESC cis rs2295499 0.773 rs2298961 chr4:2644961 T/A cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.19 -0.3 4.18e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.5 0.32 8.89e-8 Personality dimensions; CESC cis rs4727027 0.933 rs9718383 chr7:148857624 A/T cg23583168 chr7:148888333 NA 0.82 12.74 0.62 2.48e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg18876405 chr7:65276391 NA 0.5 6.48 0.37 4.33e-10 Aortic root size; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25235326 chr18:77243457 NFATC1 0.44 7.55 0.42 7.22e-13 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2180341 0.751 rs9388553 chr6:127574044 A/G cg24812749 chr6:127587940 RNF146 0.86 11.86 0.59 2.62e-26 Breast cancer; CESC cis rs6460942 0.597 rs13245635 chr7:12526454 T/A cg02935154 chr7:12443704 VWDE -0.55 -5.53 -0.32 7.71e-8 Coronary artery disease; CESC cis rs2404602 0.735 rs62028423 chr15:76754514 G/A cg23625390 chr15:77176239 SCAPER -0.42 -5.83 -0.34 1.58e-8 Blood metabolite levels; CESC cis rs6912958 0.630 rs4707377 chr6:88280332 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.58 -0.37 2.55e-10 Monocyte percentage of white cells; CESC trans rs10924245 0.867 rs77520445 chr1:245734275 T/C cg05754179 chr11:125985044 NA 0.55 6.14 0.35 2.95e-9 Schizophrenia; CESC cis rs59918340 0.509 rs11784862 chr8:142203452 T/C cg23750338 chr8:142222470 SLC45A4 0.46 6.36 0.36 8.6e-10 Immature fraction of reticulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13038030 chr17:73267041 MIF4GD 0.46 6.28 0.36 1.34e-9 Gut microbiota (bacterial taxa); CESC trans rs7819412 0.521 rs10100660 chr8:11038885 T/A cg06636001 chr8:8085503 FLJ10661 -0.53 -6.12 -0.35 3.27e-9 Triglycerides; CESC cis rs9399135 0.967 rs1023179 chr6:135343829 T/A cg22676075 chr6:135203613 NA 0.51 7.36 0.41 2.34e-12 Red blood cell count; CESC cis rs12765878 1.000 rs10883943 chr10:105651416 G/T cg24587175 chr10:105670608 OBFC1 0.32 5.36 0.31 1.81e-7 Coronary artery disease; CESC cis rs151234 0.800 rs231972 chr16:28538336 A/C cg01378222 chr16:28622494 SULT1A1 -0.5 -6.1 -0.35 3.8e-9 Platelet distribution width; CESC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 7.46 0.42 1.24e-12 Personality dimensions; CESC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.82 8.2 0.45 1.06e-14 Platelet count; CESC cis rs2797160 0.967 rs1777224 chr6:126019527 T/C cg05901451 chr6:126070800 HEY2 0.46 6.71 0.38 1.21e-10 Endometrial cancer; CESC trans rs61931739 0.500 rs12371415 chr12:34521362 C/T cg13010199 chr12:38710504 ALG10B 0.5 6.41 0.37 6.56e-10 Morning vs. evening chronotype; CESC cis rs4835473 0.722 rs7666296 chr4:144920157 G/C cg25736465 chr4:144833511 NA -0.46 -6.85 -0.39 5.22e-11 Immature fraction of reticulocytes; CESC cis rs3780486 0.846 rs7849148 chr9:33138352 A/T cg13443165 chr9:33130375 B4GALT1 0.45 6.49 0.37 4.1e-10 IgG glycosylation; CESC cis rs2280018 0.526 rs2966129 chr16:15152927 A/C cg27102117 chr16:15229624 NA -0.52 -7.8 -0.43 1.46e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs9611565 0.694 rs202616 chr22:41822221 C/G cg06634786 chr22:41940651 POLR3H 0.71 7.17 0.4 7.6e-12 Vitiligo; CESC cis rs3008870 0.701 rs2815358 chr1:67493778 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.61 7.91 0.44 7.21e-14 Lymphocyte percentage of white cells; CESC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg11644478 chr21:40555479 PSMG1 -0.55 -7.63 -0.42 4.34e-13 Menarche (age at onset); CESC cis rs34779708 0.931 rs58159560 chr10:35351249 C/T cg04310649 chr10:35416472 CREM -0.51 -6.0 -0.35 6.31e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs6502050 0.787 rs11653012 chr17:80058857 C/T cg23985595 chr17:80112537 CCDC57 0.41 6.2 0.36 2.1e-9 Life satisfaction; CESC cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg04455712 chr21:45112962 RRP1B 0.38 5.69 0.33 3.43e-8 Mean corpuscular volume; CESC cis rs5753618 0.583 rs5753601 chr22:31798259 G/T cg00478049 chr22:31556069 RNF185 -0.43 -5.11 -0.3 6.22e-7 Colorectal cancer; CESC cis rs4595586 0.545 rs1156705 chr12:39372672 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs11264213 0.591 rs274755 chr1:36544237 T/C cg27506609 chr1:36549197 TEKT2 -0.75 -7.19 -0.4 6.77e-12 Schizophrenia; CESC trans rs208520 0.874 rs208491 chr6:66928459 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.86 -9.96 -0.52 4.65e-20 Exhaled nitric oxide output; CESC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg22133161 chr19:49891603 CCDC155 0.46 5.2 0.3 4.06e-7 Multiple sclerosis; CESC cis rs11871801 0.541 rs4793090 chr17:40686342 G/A cg21433558 chr17:40837037 CNTNAP1 -0.46 -5.92 -0.34 1.01e-8 Crohn's disease; CESC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg18099408 chr3:52552593 STAB1 -0.3 -5.2 -0.3 4.06e-7 Bipolar disorder; CESC cis rs907612 0.638 rs11041476 chr11:1875067 C/T cg05305434 chr11:1874049 LSP1 0.36 6.21 0.36 2.05e-9 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; CESC cis rs7666738 0.546 rs10461174 chr4:98698293 G/A cg17366294 chr4:99064904 C4orf37 0.49 6.11 0.35 3.59e-9 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.819 rs5750629 chr22:38985065 T/C cg06022373 chr22:39101656 GTPBP1 0.94 17.17 0.73 5.98e-45 Menopause (age at onset); CESC cis rs2243480 1.000 rs10807701 chr7:65724686 C/A cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg07507251 chr3:52567010 NT5DC2 0.42 7.31 0.41 3.07e-12 Bipolar disorder; CESC cis rs1595825 0.891 rs73061068 chr2:198908439 A/G cg10820045 chr2:198174542 NA 0.39 5.03 0.3 8.84e-7 Ulcerative colitis; CESC cis rs11792861 0.926 rs1044905 chr9:111781495 G/A cg13535736 chr9:111863775 C9orf5 -0.51 -6.69 -0.38 1.35e-10 Menarche (age at onset); CESC cis rs9486715 1.000 rs7752277 chr6:97065131 C/T cg06623918 chr6:96969491 KIAA0776 -0.88 -13.19 -0.63 7.15e-31 Headache; CESC cis rs6964587 0.967 rs4729015 chr7:91561592 T/G cg17063962 chr7:91808500 NA -0.59 -7.88 -0.44 8.67e-14 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27665823 chr16:460516 DECR2 0.56 7.81 0.43 1.36e-13 Fibrinogen levels; CESC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.42 -0.5 2.37e-18 Alzheimer's disease; CESC cis rs225245 0.791 rs8067294 chr17:34027964 T/C cg05299278 chr17:33885742 SLFN14 0.39 5.51 0.32 8.5e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs5769765 0.632 rs13056783 chr22:50259152 A/T cg22709217 chr22:50311962 ALG12;CRELD2 0.47 5.51 0.32 8.55e-8 Schizophrenia; CESC cis rs400736 0.860 rs371452 chr1:8084051 C/T cg25007680 chr1:8021821 PARK7 0.71 10.25 0.53 5.59e-21 Response to antidepressants and depression; CESC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg06456125 chr7:65229604 NA -0.4 -5.29 -0.31 2.53e-7 Calcium levels; CESC cis rs11048434 0.673 rs1124402 chr12:9062606 C/T cg04155231 chr12:9217510 LOC144571 0.33 5.33 0.31 2.09e-7 Sjögren's syndrome; CESC cis rs965513 1.000 rs10983700 chr9:100537455 T/C cg13688889 chr9:100608707 NA -0.61 -8.64 -0.47 5.56e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs8180040 0.739 rs4683320 chr3:47152992 C/T cg27129171 chr3:47204927 SETD2 0.73 11.32 0.57 1.71e-24 Colorectal cancer; CESC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg06634786 chr22:41940651 POLR3H -0.68 -6.84 -0.39 5.6e-11 Vitiligo; CESC cis rs9287719 0.967 rs10929688 chr2:10756650 T/C cg02196655 chr2:10830764 NOL10 -0.36 -5.52 -0.32 8.15e-8 Prostate cancer; CESC cis rs854765 0.547 rs4459604 chr17:17888549 A/G cg09796270 chr17:17721594 SREBF1 0.38 5.11 0.3 6.08e-7 Total body bone mineral density; CESC trans rs10500991 0.587 rs11605315 chr11:24889365 T/C cg07129253 chr8:30890560 PURG;WRN -0.5 -6.6 -0.38 2.23e-10 Iron status biomarkers; CESC cis rs4466137 0.903 rs3734092 chr5:83016743 C/T cg16102102 chr5:83017553 HAPLN1 -0.51 -7.2 -0.4 6.22e-12 Prostate cancer; CESC cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.94 0.62 5.09e-30 Personality dimensions; CESC cis rs9300255 0.568 rs1790108 chr12:123636841 A/G cg05973401 chr12:123451056 ABCB9 0.5 5.77 0.33 2.18e-8 Neutrophil percentage of white cells; CESC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg21951975 chr1:209979733 IRF6 0.61 7.53 0.42 8.13e-13 Cleft lip with or without cleft palate; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08916340 chr10:112631462 LOC282997;PDCD4 -0.48 -6.21 -0.36 2.05e-9 Ulcerative colitis; CESC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg22920501 chr2:26401640 FAM59B -0.69 -8.44 -0.46 2.06e-15 Gut microbiome composition (summer); CESC cis rs75804782 0.641 rs11904390 chr2:239344663 T/A cg18131467 chr2:239335373 ASB1 -0.68 -5.96 -0.34 8.16e-9 Morning vs. evening chronotype;Chronotype; CESC cis rs847577 0.677 rs10242903 chr7:97741795 C/T cg21770322 chr7:97807741 LMTK2 -0.5 -7.17 -0.4 7.68e-12 Breast cancer; CESC trans rs3780486 0.874 rs10813955 chr9:33141791 C/T cg04842962 chr6:43655489 MRPS18A 1.0 18.63 0.75 4.36e-50 IgG glycosylation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14422660 chr6:105628044 POPDC3 0.4 6.33 0.36 1.06e-9 Gambling; CESC cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.5 -6.29 -0.36 1.34e-9 Tonsillectomy; CESC cis rs2286503 0.839 rs2240726 chr7:22853135 C/T cg13679077 chr7:22862647 TOMM7 0.45 5.77 0.33 2.2e-8 Fibrinogen; CESC cis rs1348850 0.914 rs1348849 chr2:178358072 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.89 12.98 0.62 3.87e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2204008 0.570 rs1315664 chr12:38138274 A/G cg26384229 chr12:38710491 ALG10B -0.44 -5.99 -0.35 6.87e-9 Bladder cancer; CESC cis rs1008375 1.000 rs6854733 chr4:17640526 C/T cg15017067 chr4:17643749 FAM184B 0.35 5.07 0.3 7.59e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2262909 1.000 rs2017962 chr19:22208751 T/C cg11619707 chr19:22235551 ZNF257 -0.35 -5.7 -0.33 3.19e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs9584850 0.834 rs12463 chr13:99105302 G/A cg20750642 chr13:99100586 FARP1 -0.38 -5.78 -0.33 2.05e-8 Neuroticism; CESC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg11644478 chr21:40555479 PSMG1 -0.8 -11.95 -0.59 1.27e-26 Cognitive function; CESC cis rs62103177 0.810 rs62096745 chr18:77619135 A/G cg12964065 chr18:77638022 KCNG2 0.59 5.71 0.33 2.97e-8 Opioid sensitivity; CESC cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs864537 0.618 rs2988277 chr1:167431352 A/G cg22356347 chr1:167427500 CD247 0.42 8.53 0.46 1.15e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs2108622 0.727 rs12611242 chr19:15978564 G/A cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16008945 chr10:14996031 DCLRE1C 0.55 6.49 0.37 4.25e-10 Gut microbiome composition (summer); CESC cis rs11122272 0.735 rs2749717 chr1:231489353 G/T cg06096015 chr1:231504339 EGLN1 0.41 5.9 0.34 1.1e-8 Hemoglobin concentration; CESC cis rs4555082 0.874 rs56263609 chr14:105756944 C/T cg13114125 chr14:105738426 BRF1 -0.89 -10.53 -0.54 7.09e-22 Mean platelet volume;Platelet distribution width; CESC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs713587 0.713 rs11125884 chr2:25239264 C/T cg01884057 chr2:25150051 NA 0.38 7.33 0.41 2.87e-12 Body mass index in non-asthmatics; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21454386 chr13:114292018 TFDP1 0.45 6.08 0.35 4.25e-9 Fibrinogen levels; CESC cis rs561341 1.000 rs55962687 chr17:30260369 C/T cg19193384 chr17:30244184 NA -0.63 -5.95 -0.34 8.64e-9 Hip circumference adjusted for BMI; CESC cis rs710216 0.917 rs900837 chr1:43412793 A/G cg22176566 chr1:43424700 SLC2A1 -0.5 -5.54 -0.32 7.23e-8 Red cell distribution width; CESC cis rs11098499 0.954 rs13145352 chr4:120409963 C/T cg24375607 chr4:120327624 NA -0.43 -5.12 -0.3 5.89e-7 Corneal astigmatism; CESC cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg17143192 chr8:8559678 CLDN23 0.4 5.05 0.3 8.22e-7 Mood instability; CESC cis rs963731 0.649 rs7577088 chr2:39233500 G/A cg04010122 chr2:39346883 SOS1 -0.72 -5.46 -0.32 1.09e-7 Corticobasal degeneration; CESC cis rs3741151 0.773 rs73542990 chr11:73134398 C/T cg17517138 chr11:73019481 ARHGEF17 0.94 6.86 0.39 4.87e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs12659622 0.703 rs17523908 chr5:15696499 G/T cg22457238 chr19:58570995 ZNF135 -0.55 -6.17 -0.35 2.48e-9 Obesity-related traits; CESC cis rs2806561 0.929 rs2903545 chr1:23541108 C/T cg12483005 chr1:23474871 LUZP1 -0.33 -5.33 -0.31 2.07e-7 Height; CESC cis rs7216064 1.000 rs7224923 chr17:65842265 T/G cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.73e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg27266027 chr21:40555129 PSMG1 0.47 5.67 0.33 3.69e-8 Cognitive function; CESC cis rs9611565 0.500 rs2011053 chr22:42121278 G/A cg06481639 chr22:41940642 POLR3H 0.48 5.56 0.32 6.63e-8 Vitiligo; CESC cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg09455208 chr3:40491958 NA -0.41 -6.53 -0.37 3.31e-10 Renal cell carcinoma; CESC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg14262678 chr6:151773367 RMND1;C6orf211 0.63 8.86 0.48 1.23e-16 Menarche (age at onset); CESC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg12463550 chr7:65579703 CRCP -0.5 -6.43 -0.37 5.9e-10 Aortic root size; CESC cis rs9487051 0.676 rs2884013 chr6:109599952 C/T cg21918786 chr6:109611834 NA -0.37 -5.5 -0.32 9.15e-8 Reticulocyte fraction of red cells; CESC cis rs72634258 0.554 rs68024107 chr1:7914066 G/C cg00042356 chr1:8021962 PARK7 0.57 5.49 0.32 9.24e-8 Inflammatory bowel disease; CESC cis rs12079745 0.793 rs57776592 chr1:169268023 A/G cg09363564 chr1:169337483 NME7;BLZF1 -1.0 -6.04 -0.35 5.12e-9 QT interval; CESC cis rs6088590 0.735 rs6088618 chr20:33409350 G/A cg06115741 chr20:33292138 TP53INP2 0.61 7.67 0.43 3.19e-13 Coronary artery disease; CESC cis rs11858210 1 rs11858210 chr15:79078358 G/A cg04896959 chr15:78267971 NA 0.34 5.09 0.3 6.64e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs763121 0.962 rs6001193 chr22:39074737 A/G cg14440974 chr22:39074834 NA -0.36 -5.23 -0.31 3.4e-7 Menopause (age at onset); CESC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg27170947 chr2:26402098 FAM59B -0.58 -6.93 -0.39 3.18e-11 Gut microbiome composition (summer); CESC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg27165867 chr14:105738592 BRF1 -0.52 -5.77 -0.33 2.22e-8 Mean platelet volume;Platelet distribution width; CESC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.48 0.58 5.13e-25 Alzheimer's disease; CESC trans rs7191820 0.605 rs1876764 chr16:79364932 T/C cg02396914 chr8:120743868 TAF2 -0.52 -6.74 -0.38 9.67e-11 Obesity-related traits; CESC cis rs1400745 0.756 rs3783314 chr14:35337384 T/C cg16230307 chr14:35515116 FAM177A1 0.44 5.25 0.31 3.18e-7 Monocyte count; CESC cis rs6963495 0.818 rs6977748 chr7:105167462 T/G cg02135003 chr7:105160482 PUS7 -0.46 -5.25 -0.31 3.19e-7 Bipolar disorder (body mass index interaction); CESC cis rs2404602 0.716 rs2404737 chr15:76872217 T/G cg26408565 chr15:76604113 ETFA -0.39 -5.66 -0.33 4.02e-8 Blood metabolite levels; CESC cis rs7178572 0.524 rs12914128 chr15:77493875 T/C cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC cis rs714031 1.000 rs4821909 chr22:40066418 T/C cg21377881 chr22:40064566 CACNA1I -0.34 -5.47 -0.32 1.06e-7 Schizophrenia; CESC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg15352829 chr14:105391018 PLD4 0.61 10.68 0.55 2.23e-22 Rheumatoid arthritis; CESC cis rs6582630 0.532 rs1589394 chr12:38419700 A/C cg26384229 chr12:38710491 ALG10B 0.46 6.73 0.38 1.05e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs11098499 0.754 rs12506487 chr4:120271361 T/G cg09307838 chr4:120376055 NA 0.77 10.19 0.53 8.72e-21 Corneal astigmatism; CESC cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg02891314 chr5:179741120 GFPT2 -0.7 -9.34 -0.5 3.96e-18 Height; CESC cis rs6460942 0.915 rs75158182 chr7:12456059 C/T cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs35146811 0.844 rs13232115 chr7:99670932 T/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.45 5.74 0.33 2.65e-8 Coronary artery disease; CESC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg03806693 chr22:41940476 POLR3H 1.13 15.51 0.69 4.94e-39 Vitiligo; CESC trans rs61931739 0.500 rs11053203 chr12:34456593 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.44 0.54 1.34e-21 Morning vs. evening chronotype; CESC trans rs60843830 0.508 rs300750 chr2:208794 T/G cg06230206 chr11:126456119 KIRREL3 0.37 6.63 0.38 1.91e-10 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9300255 0.602 rs1716160 chr12:123700225 C/T cg19016782 chr12:123741754 C12orf65 -0.45 -6.5 -0.37 3.89e-10 Neutrophil percentage of white cells; CESC cis rs3892630 0.824 rs34748593 chr19:33240447 T/C cg13157960 chr19:33183277 NUDT19 0.55 5.12 0.3 5.91e-7 Red blood cell traits; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09849967 chr3:49138870 QARS -0.42 -6.06 -0.35 4.54e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.42 -0.32 1.31e-7 Aortic root size; CESC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg19346786 chr7:2764209 NA -0.49 -7.02 -0.4 1.86e-11 Height; CESC cis rs34779708 0.931 rs13377158 chr10:35370465 A/C cg03585969 chr10:35415529 CREM -0.74 -10.07 -0.53 2.12e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7818688 1.000 rs7002940 chr8:96027392 G/A cg16049864 chr8:95962084 TP53INP1 0.58 5.63 0.33 4.56e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1256061 0.646 rs1152588 chr14:64688175 G/C cg23250157 chr14:64679961 SYNE2 0.53 7.35 0.41 2.5e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg18305652 chr10:134549665 INPP5A 0.48 6.75 0.38 9.22e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg02569458 chr12:86230093 RASSF9 0.5 7.43 0.42 1.49e-12 Major depressive disorder; CESC cis rs3008870 0.727 rs11208971 chr1:67383901 G/A cg02640540 chr1:67518911 SLC35D1 0.44 5.26 0.31 2.94e-7 Lymphocyte percentage of white cells; CESC cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg08847533 chr14:75593920 NEK9 0.96 16.63 0.71 5.16e-43 Height; CESC cis rs4662945 0.504 rs35568023 chr2:130251812 A/T cg05903289 chr2:130345205 NA -0.4 -6.23 -0.36 1.83e-9 Response to cytidine analogues (gemcitabine); CESC cis rs13242816 1.000 rs35184471 chr7:116133246 G/A cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC cis rs950027 0.787 rs1547487 chr15:45723983 A/G cg21132104 chr15:45694354 SPATA5L1 0.47 5.55 0.32 6.87e-8 Response to fenofibrate (adiponectin levels); CESC cis rs11098499 0.863 rs6835635 chr4:120458867 A/G cg24375607 chr4:120327624 NA 0.44 5.33 0.31 2.13e-7 Corneal astigmatism; CESC cis rs1421811 0.509 rs7733428 chr5:32689850 G/A cg16267343 chr5:32710456 NPR3 0.58 6.53 0.37 3.3e-10 Blood pressure; CESC cis rs1950626 0.623 rs34448411 chr14:101429287 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.68 9.19 0.49 1.18e-17 Pelvic organ prolapse (moderate/severe); CESC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg18876405 chr7:65276391 NA 0.49 6.55 0.37 3e-10 Aortic root size; CESC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg17971929 chr21:40555470 PSMG1 -0.58 -7.57 -0.42 6.25e-13 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13398782 chr1:23857288 E2F2 0.56 6.52 0.37 3.48e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg18230493 chr5:56204884 C5orf35 -0.58 -7.69 -0.43 2.89e-13 Coronary artery disease; CESC cis rs897984 0.721 rs2305884 chr16:30970741 G/A cg00531865 chr16:30841666 NA 0.51 7.02 0.4 1.83e-11 Dementia with Lewy bodies; CESC trans rs9354308 0.868 rs1938063 chr6:66559098 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.54 -6.52 -0.37 3.6e-10 Metabolite levels; CESC cis rs10883723 0.737 rs11191312 chr10:104278601 T/C cg22532475 chr10:104410764 TRIM8 -0.41 -6.32 -0.36 1.08e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs7130144 0.541 rs7949571 chr11:130462430 A/G cg26307797 chr11:130446613 NA -0.76 -6.78 -0.38 7.92e-11 Urate levels in lean individuals; CESC cis rs73110464 0.562 rs2363634 chr12:53354683 A/G cg25025879 chr12:53359317 NA -0.6 -7.9 -0.44 7.28e-14 Cancer (pleiotropy); CESC cis rs7654585 0.645 rs1123943 chr4:25924426 A/G cg10409131 chr4:25915609 C4orf52 -0.66 -8.7 -0.47 3.65e-16 Obesity-related traits; CESC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.97 0.8 1.29e-61 Prudent dietary pattern; CESC cis rs1003719 1.000 rs2835607 chr21:38491973 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.64 8.63 0.47 5.67e-16 Eye color traits; CESC cis rs6831352 0.734 rs2602856 chr4:100029145 C/A cg13256891 chr4:100009986 ADH5 0.67 8.04 0.44 2.92e-14 Alcohol dependence; CESC cis rs6141600 0.540 rs761312 chr20:34687809 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -5.99 -0.35 6.69e-9 Height;Hip circumference; CESC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.1 -0.35 3.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs501120 0.636 rs3123689 chr10:44773121 G/A cg09554077 chr10:44749378 NA 0.52 6.94 0.39 3.05e-11 Coronary artery disease;Coronary heart disease; CESC cis rs7666738 0.830 rs9992639 chr4:98940400 G/T cg03467027 chr4:99064603 C4orf37 0.48 5.92 0.34 9.97e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg07636037 chr3:49044803 WDR6 0.79 12.9 0.62 6.92e-30 Menarche (age at onset); CESC cis rs16922576 0.623 rs2104166 chr9:5230447 T/C cg02405213 chr9:5042618 JAK2 -0.51 -6.34 -0.36 1.01e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs6754311 0.731 rs309164 chr2:136691825 T/C cg07169764 chr2:136633963 MCM6 0.71 9.13 0.49 1.8e-17 Mosquito bite size; CESC cis rs863345 0.604 rs11264991 chr1:158472861 T/G cg12129480 chr1:158549410 OR10X1 -0.35 -7.04 -0.4 1.66e-11 Pneumococcal bacteremia; CESC cis rs829883 0.659 rs11109510 chr12:98911382 A/G cg25150519 chr12:98850993 NA -0.65 -7.95 -0.44 5.42e-14 Colorectal adenoma (advanced); CESC cis rs2273669 0.667 rs11153154 chr6:109357324 G/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.33 -0.36 1.02e-9 Prostate cancer; CESC cis rs2072499 0.898 rs2758609 chr1:156202868 G/A cg25208724 chr1:156163844 SLC25A44 0.84 13.27 0.63 3.75e-31 Testicular germ cell tumor; CESC cis rs9308433 0.529 rs4655243 chr1:214497291 A/G cg06198575 chr1:214491504 SMYD2 0.49 5.98 0.34 7.22e-9 IgG glycosylation; CESC cis rs8077577 0.945 rs62073649 chr17:18080522 T/C cg16794390 chr17:18148240 FLII 0.44 5.74 0.33 2.54e-8 Obesity-related traits; CESC trans rs877282 0.945 rs10904550 chr10:774177 C/T cg22713356 chr15:30763199 NA 1.12 11.29 0.57 2.14e-24 Uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11042866 chr11:65626132 CFL1 -0.54 -6.32 -0.36 1.08e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02963556 chr12:132588637 EP400NL 0.47 6.26 0.36 1.54e-9 Fibrinogen levels; CESC cis rs9399135 0.967 rs4142299 chr6:135377186 G/T cg24558204 chr6:135376177 HBS1L 0.52 7.19 0.4 6.52e-12 Red blood cell count; CESC cis rs698833 0.886 rs786613 chr2:44590066 C/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.54 -7.04 -0.4 1.68e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs10871290 1.000 rs11149710 chr16:74472546 G/T cg01733217 chr16:74700730 RFWD3 -0.64 -8.56 -0.47 9.44e-16 Breast cancer; CESC cis rs1065852 0.526 rs9611700 chr22:42401514 C/T cg22189786 chr22:42395067 WBP2NL 0.43 5.34 0.31 2e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs7044106 0.708 rs1324472 chr9:123375110 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.09 0.3 6.82e-7 Hip circumference adjusted for BMI; CESC cis rs6121246 0.567 rs6060297 chr20:30198560 A/G cg13852791 chr20:30311386 BCL2L1 0.58 5.47 0.32 1.03e-7 Mean corpuscular hemoglobin; CESC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg11764359 chr7:65958608 NA 0.79 11.32 0.57 1.67e-24 Aortic root size; CESC cis rs7680126 0.633 rs4697743 chr4:10294833 A/G cg11266682 chr4:10021025 SLC2A9 -0.43 -5.6 -0.33 5.38e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg27170947 chr2:26402098 FAM59B -0.83 -10.36 -0.54 2.42e-21 Gut microbiome composition (summer); CESC cis rs17401966 1.000 rs35766535 chr1:10284659 T/C cg15208524 chr1:10270712 KIF1B 0.51 6.64 0.38 1.78e-10 Hepatocellular carcinoma; CESC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg00166722 chr3:10149974 C3orf24 0.48 5.95 0.34 8.39e-9 Alzheimer's disease; CESC cis rs6963495 0.818 rs6973263 chr7:105170293 A/G cg02135003 chr7:105160482 PUS7 -0.46 -5.5 -0.32 9.1e-8 Bipolar disorder (body mass index interaction); CESC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg19680485 chr15:31195859 MTMR15 0.5 6.02 0.35 5.9e-9 Huntington's disease progression; CESC cis rs1707322 1.000 rs11211205 chr1:46321874 C/T cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2011503 1.000 rs754256 chr19:19578591 A/G cg11584989 chr19:19387371 SF4 -0.57 -6.45 -0.37 5.19e-10 Bipolar disorder; CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg10819733 chr22:24237672 NA -0.48 -6.92 -0.39 3.43e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10727759 chr12:50017361 PRPF40B -0.45 -6.0 -0.35 6.46e-9 Ulcerative colitis; CESC cis rs820218 0.717 rs9910627 chr17:73655529 C/T cg01592526 chr17:73663357 RECQL5;SAP30BP -0.4 -5.4 -0.31 1.47e-7 Rotator cuff tears; CESC cis rs9908102 0.740 rs4792311 chr17:12915009 A/G cg26162695 chr17:12921313 ELAC2 -0.54 -5.96 -0.34 8.1e-9 Schizophrenia; CESC cis rs12325245 0.536 rs17821549 chr16:58554780 C/T cg01152986 chr16:58549298 SETD6 0.85 5.17 0.3 4.54e-7 Schizophrenia; CESC cis rs2996428 0.667 rs2368534 chr1:3740640 C/T cg13057898 chr1:3703894 LRRC47 0.45 6.1 0.35 3.65e-9 Red cell distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05144345 chr4:1686368 FAM53A 0.58 7.09 0.4 1.19e-11 Gut microbiome composition (summer); CESC cis rs6547741 0.935 rs6761095 chr2:27778010 G/T cg27432699 chr2:27873401 GPN1 0.44 6.1 0.35 3.8e-9 Oral cavity cancer; CESC cis rs4253772 0.591 rs12167567 chr22:46659942 G/C cg24881330 chr22:46731750 TRMU 0.86 9.62 0.51 5.71e-19 LDL cholesterol;Cholesterol, total; CESC cis rs1538970 0.884 rs781226 chr1:45872662 T/C cg05343316 chr1:45956843 TESK2 -0.78 -11.06 -0.56 1.3e-23 Platelet count; CESC cis rs3796352 1.000 rs7622420 chr3:53111069 A/G cg12962167 chr3:53033115 SFMBT1 0.53 5.76 0.33 2.28e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg25767906 chr1:53392781 SCP2 0.53 7.72 0.43 2.46e-13 Monocyte count; CESC cis rs16854884 0.609 rs2885197 chr3:143636616 A/T cg06585982 chr3:143692056 C3orf58 -0.44 -5.52 -0.32 8.23e-8 Economic and political preferences (feminism/equality); CESC cis rs7918232 0.830 rs10764672 chr10:27392541 A/C cg14240646 chr10:27532245 ACBD5 0.51 5.27 0.31 2.79e-7 Breast cancer; CESC cis rs9902453 0.765 rs2447935 chr17:28057524 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.76 -10.3 -0.53 3.95e-21 Coffee consumption (cups per day); CESC cis rs6904897 0.538 rs4639353 chr6:135224328 A/G cg22676075 chr6:135203613 NA -0.66 -9.75 -0.51 2.13e-19 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs3806843 0.966 rs10036519 chr5:140151701 C/T cg26395211 chr5:140044315 WDR55 0.41 5.38 0.31 1.61e-7 Depressive symptoms (multi-trait analysis); CESC cis rs738322 1.000 rs738322 chr22:38569006 A/G cg17652424 chr22:38574118 PLA2G6 -0.34 -6.03 -0.35 5.39e-9 Cutaneous nevi; CESC trans rs7943203 1.000 rs10431061 chr11:108288808 G/T cg01416241 chr5:148737479 PCYOX1L -0.48 -6.25 -0.36 1.61e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs57244997 0.685 rs2226770 chr6:162447251 C/T cg17173639 chr6:162384350 PARK2 0.59 6.19 0.36 2.29e-9 Mosquito bite size; CESC cis rs853679 0.599 rs149990 chr6:27998258 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.8 6.55 0.37 2.92e-10 Depression; CESC cis rs853679 0.556 rs45509595 chr6:27840926 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.9 6.23 0.36 1.82e-9 Depression; CESC cis rs10791323 0.546 rs55801927 chr11:133713094 A/C cg15485101 chr11:133734466 NA 0.4 6.59 0.38 2.34e-10 Childhood ear infection; CESC cis rs2404602 0.647 rs118129828 chr15:77015200 T/C cg23625390 chr15:77176239 SCAPER -0.47 -6.52 -0.37 3.54e-10 Blood metabolite levels; CESC cis rs7193541 0.684 rs9931225 chr16:74699293 T/C cg05580060 chr16:74700937 RFWD3 -0.45 -5.77 -0.33 2.2e-8 Multiple myeloma; CESC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs9527 0.637 rs7085104 chr10:104628873 A/G cg04362960 chr10:104952993 NT5C2 0.52 6.23 0.36 1.79e-9 Arsenic metabolism; CESC cis rs10504229 0.817 rs55949560 chr8:58167603 T/C cg22535103 chr8:58192502 C8orf71 -0.84 -11.02 -0.56 1.76e-23 Developmental language disorder (linguistic errors); CESC cis rs3015497 0.624 rs3015486 chr14:51135330 A/G cg26011998 chr14:51135199 SAV1 -0.62 -7.02 -0.4 1.82e-11 Mean platelet volume; CESC cis rs4268898 0.662 rs2303296 chr2:24432839 A/G cg06627628 chr2:24431161 ITSN2 -1.02 -11.2 -0.57 4.2e-24 Asthma; CESC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg04553112 chr3:125709451 NA -0.5 -5.48 -0.32 9.86e-8 Blood pressure (smoking interaction); CESC cis rs4595586 0.545 rs12827823 chr12:39392144 G/T cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs8002861 0.875 rs12428432 chr13:44464043 A/G cg14210620 chr13:44453864 C13orf31;CCDC122 -0.44 -5.58 -0.32 5.88e-8 Leprosy; CESC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg18135555 chr8:22132992 PIWIL2 0.25 5.31 0.31 2.37e-7 Hypertriglyceridemia; CESC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg07308232 chr7:1071921 C7orf50 -0.6 -8.51 -0.46 1.29e-15 Longevity;Endometriosis; CESC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs6831352 1.000 rs6532798 chr4:100054827 C/T cg13256891 chr4:100009986 ADH5 0.73 8.48 0.46 1.62e-15 Alcohol dependence; CESC cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg25427524 chr10:38739819 LOC399744 0.65 9.07 0.49 2.71e-17 Extrinsic epigenetic age acceleration; CESC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg00750074 chr16:89608354 SPG7 -0.44 -6.44 -0.37 5.61e-10 Multiple myeloma (IgH translocation); CESC cis rs67311347 0.869 rs6790495 chr3:40366770 C/T cg09455208 chr3:40491958 NA 0.48 7.97 0.44 4.61e-14 Renal cell carcinoma; CESC cis rs796364 1.000 rs35594306 chr2:200775125 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.83 -6.41 -0.37 6.49e-10 Schizophrenia; CESC cis rs7847628 0.551 rs10818476 chr9:123572038 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.82 13.23 0.63 5.01e-31 Birth weight; CESC cis rs4925386 0.681 rs2427296 chr20:60927475 G/A cg22307297 chr20:60903441 LAMA5 0.37 5.28 0.31 2.65e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg05265985 chr11:20412000 PRMT3 0.43 6.37 0.36 8.51e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6541297 0.941 rs6541294 chr1:230278826 A/G cg20703242 chr1:230279135 GALNT2 0.68 10.87 0.56 5.47e-23 Coronary artery disease; CESC cis rs6546550 0.901 rs6725425 chr2:70150674 T/C cg02498382 chr2:70120550 SNRNP27 -0.41 -7.26 -0.41 4.34e-12 Prevalent atrial fibrillation; CESC cis rs7927592 0.717 rs7126451 chr11:68257386 A/G cg16797656 chr11:68205561 LRP5 -0.5 -7.84 -0.43 1.1e-13 Total body bone mineral density; CESC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg24503407 chr1:205819492 PM20D1 0.48 7.23 0.41 5.18e-12 Menarche (age at onset); CESC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg04553112 chr3:125709451 NA -0.51 -5.37 -0.31 1.7e-7 Blood pressure (smoking interaction); CESC cis rs3820928 0.874 rs13385711 chr2:227830414 G/T cg11843606 chr2:227700838 RHBDD1 -0.44 -5.74 -0.33 2.6e-8 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17205877 chr22:41842716 TOB2 0.56 6.38 0.36 7.68e-10 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg04414720 chr1:150670196 GOLPH3L -0.63 -8.94 -0.48 6.83e-17 Tonsillectomy; CESC cis rs4906332 1.000 rs28711288 chr14:103906126 T/C cg09975044 chr14:104007538 NA 0.48 6.67 0.38 1.46e-10 Coronary artery disease; CESC cis rs748404 0.660 rs694725 chr15:43756210 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.19 0.45 1.12e-14 Lung cancer; CESC cis rs3820068 0.734 rs72645830 chr1:15889910 A/G cg18192808 chr1:15853278 DNAJC16 0.46 5.52 0.32 7.92e-8 Systolic blood pressure; CESC cis rs3733585 0.699 rs4473653 chr4:9971058 A/G cg02734326 chr4:10020555 SLC2A9 -0.41 -5.81 -0.34 1.79e-8 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06584028 chr2:69614451 GFPT1 0.59 6.29 0.36 1.28e-9 Gut microbiome composition (summer); CESC cis rs11209002 0.567 rs983111 chr1:67539356 T/C cg02640540 chr1:67518911 SLC35D1 0.47 5.39 0.31 1.52e-7 Crohn's disease; CESC cis rs17539620 0.506 rs62432749 chr6:154839219 G/A cg20019720 chr6:154832845 CNKSR3 0.46 6.04 0.35 5.07e-9 Lipoprotein (a) levels; CESC cis rs1355223 0.552 rs2421743 chr11:34882840 C/T cg24088639 chr11:34937564 PDHX;APIP -0.4 -5.12 -0.3 5.76e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7084402 0.967 rs1649072 chr10:60298112 G/A cg07615347 chr10:60278583 BICC1 0.6 9.46 0.5 1.77e-18 Refractive error; CESC cis rs8077577 0.895 rs62072500 chr17:18126918 A/C cg16794390 chr17:18148240 FLII 0.43 5.8 0.34 1.92e-8 Obesity-related traits; CESC cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg06713675 chr4:122721982 EXOSC9 -0.5 -6.81 -0.39 6.6e-11 Type 2 diabetes; CESC cis rs4604732 0.631 rs11490201 chr1:247626262 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg17366294 chr4:99064904 C4orf37 0.63 8.7 0.47 3.53e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6831352 0.837 rs2924583 chr4:100044640 T/C cg12011299 chr4:100065546 ADH4 0.59 6.66 0.38 1.56e-10 Alcohol dependence; CESC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg12463550 chr7:65579703 CRCP -0.55 -7.0 -0.39 2.15e-11 Aortic root size; CESC cis rs910316 1.000 rs10138183 chr14:75615227 T/C cg11812906 chr14:75593930 NEK9 0.91 15.77 0.7 5.67e-40 Height; CESC cis rs7666738 0.830 rs13125930 chr4:98654695 G/A cg05340658 chr4:99064831 C4orf37 0.76 10.99 0.56 2.11e-23 Colonoscopy-negative controls vs population controls; CESC cis rs7945705 0.520 rs1984791 chr11:9035027 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.35 5.56 0.32 6.66e-8 Hemoglobin concentration; CESC cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg00475322 chr7:917719 C7orf20 0.46 5.19 0.3 4.28e-7 Cerebrospinal P-tau181p levels; CESC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg06028605 chr16:24865363 SLC5A11 -0.56 -8.24 -0.45 7.9e-15 Intelligence (multi-trait analysis); CESC cis rs9788682 1.000 rs12441426 chr15:78812329 T/C cg06917634 chr15:78832804 PSMA4 -0.53 -6.09 -0.35 3.92e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs11098499 0.954 rs7437420 chr4:120312903 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.11e-7 Major depressive disorder; CESC cis rs2734839 1.000 rs2734839 chr11:113286490 C/T cg14159747 chr11:113255604 NA 0.3 5.4 0.31 1.52e-7 Information processing speed; CESC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.11 -0.3 6.06e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 10.22 0.53 7.11e-21 Platelet count; CESC cis rs6690583 0.573 rs61768854 chr1:85460021 T/C cg22488158 chr1:85528044 WDR63 0.55 5.18 0.3 4.45e-7 Serum sulfate level; CESC cis rs4604732 0.642 rs10925048 chr1:247640736 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.36 5.26 0.31 3.01e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2228479 0.764 rs11641201 chr16:89983276 T/C cg00800038 chr16:89945340 TCF25 -0.69 -7.09 -0.4 1.19e-11 Skin colour saturation; CESC trans rs4332037 0.539 rs56305291 chr7:2048706 A/G cg11693508 chr17:37793320 STARD3 0.67 6.77 0.38 8.32e-11 Bipolar disorder; CESC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg22433210 chr17:43662623 NA 0.99 11.32 0.57 1.75e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg03647317 chr4:187891568 NA -0.37 -5.56 -0.32 6.44e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg25208724 chr1:156163844 SLC25A44 1.01 19.18 0.76 4.95e-52 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04768184 chr8:37963284 ASH2L 0.57 6.67 0.38 1.52e-10 Gut microbiome composition (summer); CESC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg16145915 chr7:1198662 ZFAND2A -0.44 -6.22 -0.36 1.89e-9 Longevity;Endometriosis; CESC cis rs9894429 0.789 rs8074989 chr17:79598728 G/C cg21984481 chr17:79567631 NPLOC4 -0.56 -8.99 -0.48 4.98e-17 Eye color traits; CESC cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.52 0.46 1.18e-15 Hip circumference adjusted for BMI; CESC cis rs4654899 0.865 rs9426730 chr1:21452255 A/T cg05370193 chr1:21551575 ECE1 0.39 5.83 0.34 1.59e-8 Superior frontal gyrus grey matter volume; CESC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg27094323 chr7:1216898 NA -0.37 -5.05 -0.3 8.32e-7 Longevity;Endometriosis; CESC cis rs55794721 0.509 rs909834 chr1:25757996 A/G cg02931644 chr1:25747376 RHCE 0.43 7.07 0.4 1.38e-11 Plateletcrit;Mean corpuscular volume; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11286060 chr17:27182016 ERAL1 0.46 6.11 0.35 3.45e-9 Systemic lupus erythematosus; CESC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg25072359 chr17:41440525 NA 0.48 6.36 0.36 8.96e-10 Menopause (age at onset); CESC cis rs7017914 0.967 rs6991329 chr8:71593425 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.09 -0.3 6.93e-7 Bone mineral density; CESC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg06873352 chr17:61820015 STRADA 0.59 9.28 0.5 6.17e-18 Prudent dietary pattern; CESC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.7 -0.38 1.25e-10 Depression; CESC cis rs17376456 0.877 rs12109629 chr5:93359702 A/G cg21475434 chr5:93447410 FAM172A 0.77 6.93 0.39 3.17e-11 Diabetic retinopathy; CESC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg24768116 chr2:27665128 KRTCAP3 -0.31 -5.69 -0.33 3.43e-8 Total body bone mineral density; CESC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg04944784 chr2:26401820 FAM59B -0.93 -10.69 -0.55 2.11e-22 Gut microbiome composition (summer); CESC cis rs1878931 0.615 rs6501171 chr16:3402610 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.93 13.47 0.64 7.47e-32 Body mass index (adult); CESC cis rs6582630 0.502 rs7312212 chr12:38274760 T/G cg13010199 chr12:38710504 ALG10B 0.46 5.61 0.33 5.13e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04338281 chr16:54962385 NA 0.55 6.2 0.36 2.17e-9 Gut microbiome composition (summer); CESC cis rs751837 0.591 rs10135776 chr14:103411295 G/C cg10087771 chr14:103399429 CDC42BPB 0.59 5.43 0.32 1.29e-7 Large B-cell lymphoma; CESC cis rs7520050 0.966 rs785485 chr1:46574424 C/T cg03146154 chr1:46216737 IPP -0.43 -5.56 -0.32 6.67e-8 Red blood cell count;Reticulocyte count; CESC cis rs34311866 0.752 rs11725653 chr4:963397 C/T cg07828340 chr4:882639 GAK 0.86 6.67 0.38 1.49e-10 Parkinson's disease; CESC cis rs11785400 1.000 rs6988393 chr8:143740596 A/G cg24634471 chr8:143751801 JRK 0.47 6.21 0.36 2e-9 Schizophrenia; CESC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.54 -0.32 7.46e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs8141529 1.000 rs8141529 chr22:29269692 A/G cg15103426 chr22:29168792 CCDC117 0.46 5.58 0.32 5.81e-8 Lymphocyte counts; CESC cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 6.1e-17 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10475689 chr16:12142335 RUNDC2A -0.53 -7.01 -0.4 1.98e-11 Gut microbiome composition (summer); CESC cis rs6088590 1.000 rs12626122 chr20:33425800 A/G cg06115741 chr20:33292138 TP53INP2 0.6 7.14 0.4 8.98e-12 Coronary artery disease; CESC cis rs7267979 1.000 rs6050559 chr20:25329915 A/G cg08601574 chr20:25228251 PYGB 0.37 5.37 0.31 1.73e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg15556689 chr8:8085844 FLJ10661 -0.46 -5.81 -0.34 1.81e-8 Mood instability; CESC cis rs1153858 1.000 rs4271549 chr15:45652730 G/A cg21132104 chr15:45694354 SPATA5L1 0.85 11.64 0.58 1.47e-25 Homoarginine levels; CESC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg16325326 chr1:53192061 ZYG11B 0.9 15.56 0.69 3.23e-39 Monocyte count; CESC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg06505273 chr16:24850292 NA -0.52 -6.43 -0.37 5.95e-10 Intelligence (multi-trait analysis); CESC cis rs4835473 0.549 rs11940719 chr4:144892008 C/T cg25736465 chr4:144833511 NA 0.39 5.99 0.35 6.96e-9 Immature fraction of reticulocytes; CESC cis rs28374715 0.532 rs28703570 chr15:41679492 G/A cg18705301 chr15:41695430 NDUFAF1 -1.07 -17.74 -0.74 6.07e-47 Ulcerative colitis; CESC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg10691866 chr7:65817282 TPST1 -0.31 -5.16 -0.3 4.74e-7 Aortic root size; CESC cis rs12476592 0.602 rs262536 chr2:63906926 T/C cg17519650 chr2:63277830 OTX1 -0.48 -5.26 -0.31 3.01e-7 Childhood ear infection; CESC cis rs8062405 0.824 rs62034326 chr16:28539293 A/G cg07382826 chr16:28625726 SULT1A1 0.31 5.05 0.3 8.32e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9911578 1.000 rs7207693 chr17:57016525 C/T cg12560992 chr17:57184187 TRIM37 0.93 15.28 0.68 3.05e-38 Intelligence (multi-trait analysis); CESC cis rs4450131 0.522 rs34336231 chr10:126355662 C/T cg20435097 chr10:126320824 FAM53B 0.3 5.37 0.31 1.69e-7 White blood cell count (basophil); CESC cis rs6964587 0.904 rs6465339 chr7:91570790 T/A cg17063962 chr7:91808500 NA -0.57 -7.69 -0.43 2.84e-13 Breast cancer; CESC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg13777783 chr17:79615861 NA 0.36 6.15 0.35 2.83e-9 Eye color traits; CESC cis rs2506889 0.553 rs11580264 chr1:10605796 C/A cg20482658 chr1:10539492 PEX14 -0.28 -5.61 -0.33 4.97e-8 Breast cancer; CESC cis rs3096299 0.838 rs3102384 chr16:89411661 T/G cg00750074 chr16:89608354 SPG7 -0.43 -5.8 -0.34 1.91e-8 Multiple myeloma (IgH translocation); CESC cis rs7818688 1.000 rs10086541 chr8:96033950 A/G cg16049864 chr8:95962084 TP53INP1 0.55 5.85 0.34 1.42e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.63 7.73 0.43 2.2e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10927875 0.722 rs6660685 chr1:16346988 A/G cg21385522 chr1:16154831 NA 0.6 7.16 0.4 8.13e-12 Dilated cardiomyopathy; CESC cis rs9359856 0.564 rs72915904 chr6:90421412 C/A cg13799429 chr6:90582589 CASP8AP2 -0.67 -6.77 -0.38 8.26e-11 Bipolar disorder; CESC cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg10556349 chr10:835070 NA 0.56 5.34 0.31 2e-7 Eosinophil percentage of granulocytes; CESC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.57 6.96 0.39 2.69e-11 Height; CESC cis rs7301826 0.651 rs10734979 chr12:131288954 T/C cg11011512 chr12:131303247 STX2 0.47 5.82 0.34 1.71e-8 Plasma plasminogen activator levels; CESC cis rs9457247 0.967 rs385460 chr6:167403888 A/T cg25258033 chr6:167368657 RNASET2 0.39 5.88 0.34 1.26e-8 Crohn's disease; CESC cis rs11252926 0.527 rs11252754 chr10:538637 G/A cg03684893 chr10:554711 DIP2C -0.47 -7.39 -0.41 1.91e-12 Psychosis in Alzheimer's disease; CESC cis rs7799006 0.755 rs12534131 chr7:2294123 C/T cg08027265 chr7:2291960 NA -0.58 -10.02 -0.52 2.97e-20 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs8060686 0.858 rs2008173 chr16:67856240 A/G cg26727032 chr16:67993705 SLC12A4 -0.67 -9.45 -0.5 1.89e-18 HDL cholesterol;Metabolic syndrome; CESC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg17724175 chr1:150552817 MCL1 0.38 5.9 0.34 1.13e-8 Melanoma; CESC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg18876405 chr7:65276391 NA -0.53 -7.37 -0.41 2.19e-12 Aortic root size; CESC cis rs4919087 0.923 rs11189038 chr10:98974765 A/T cg25902810 chr10:99078978 FRAT1 0.67 9.67 0.51 3.88e-19 Monocyte count; CESC cis rs8045833 0.714 rs749681 chr16:88570675 A/G cg05152867 chr16:88568237 ZFPM1 0.32 5.23 0.31 3.48e-7 Vascular endothelial growth factor levels; CESC cis rs28829049 0.895 rs2313061 chr1:19360293 G/A cg13387374 chr1:19411106 UBR4 0.42 5.24 0.31 3.25e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg21963583 chr11:68658836 MRPL21 0.42 5.71 0.33 3.1e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2880765 0.835 rs56406982 chr15:86036379 G/A cg10818794 chr15:86012489 AKAP13 -0.34 -5.31 -0.31 2.3e-7 Coronary artery disease; CESC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.58 0.32 5.89e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2228479 0.557 rs11648881 chr16:89862434 T/C cg04013166 chr16:89971882 TCF25 0.76 6.45 0.37 5.36e-10 Skin colour saturation; CESC cis rs3820928 0.874 rs4675138 chr2:227884118 G/A cg05526886 chr2:227700861 RHBDD1 -0.43 -5.49 -0.32 9.36e-8 Pulmonary function; CESC cis rs72781680 0.821 rs17045981 chr2:24109316 A/G cg08917208 chr2:24149416 ATAD2B 0.66 6.55 0.37 2.91e-10 Lymphocyte counts; CESC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg26343298 chr8:95960752 TP53INP1 0.36 6.05 0.35 4.98e-9 Type 2 diabetes; CESC cis rs3820928 0.967 rs16822905 chr2:227770727 G/C cg11843606 chr2:227700838 RHBDD1 -0.4 -5.22 -0.31 3.58e-7 Pulmonary function; CESC cis rs4805272 0.512 rs66830923 chr19:29321277 C/T cg14983838 chr19:29218262 NA 0.45 5.38 0.31 1.66e-7 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg06026331 chr20:60912101 LAMA5 0.46 5.09 0.3 6.77e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs807669 0.868 rs2800973 chr22:19168616 A/G cg02655711 chr22:19163373 SLC25A1 0.95 14.93 0.68 5.37e-37 Metabolite levels; CESC cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg11166453 chr1:247681781 NA 0.45 5.59 0.32 5.53e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs10744422 0.748 rs2292138 chr12:123339712 A/G cg25930673 chr12:123319894 HIP1R -0.76 -5.88 -0.34 1.26e-8 Schizophrenia; CESC cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg05347473 chr6:146136440 FBXO30 0.55 7.21 0.4 5.99e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg16561543 chr14:105714843 BRF1;BTBD6 0.48 6.03 0.35 5.51e-9 Psoriatic arthritis; CESC cis rs9660992 0.710 rs1768586 chr1:205238275 A/G cg21643547 chr1:205240462 TMCC2 -0.49 -6.84 -0.39 5.31e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg19774624 chr17:42201019 HDAC5 -0.7 -10.12 -0.53 1.49e-20 Total body bone mineral density; CESC cis rs2354432 0.607 rs59689207 chr1:146722484 G/A cg25205988 chr1:146714368 CHD1L -1.01 -8.47 -0.46 1.68e-15 Mitochondrial DNA levels; CESC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg05872129 chr22:39784769 NA -0.8 -10.34 -0.54 2.79e-21 Intelligence (multi-trait analysis); CESC cis rs4237845 0.837 rs7954957 chr12:58299250 C/T cg02175503 chr12:58329896 NA 0.65 9.29 0.5 5.97e-18 Intelligence (multi-trait analysis); CESC cis rs35849525 0.776 rs7615318 chr3:49987475 C/T cg24308560 chr3:49941425 MST1R -0.53 -6.43 -0.37 6.09e-10 Intelligence (multi-trait analysis); CESC cis rs6032067 0.929 rs6017504 chr20:43818920 G/A cg11264863 chr20:43835661 SEMG1 0.49 5.29 0.31 2.5e-7 Blood protein levels; CESC cis rs858239 0.669 rs1006709 chr7:23140099 C/T cg27449745 chr7:23145252 KLHL7 -0.48 -6.37 -0.36 8.44e-10 Cerebrospinal fluid biomarker levels; CESC cis rs460214 0.564 rs9979888 chr21:40022099 A/G cg05519781 chr21:40033154 ERG 0.45 5.53 0.32 7.65e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs7845219 0.544 rs9643351 chr8:95917290 C/T cg13393036 chr8:95962371 TP53INP1 -0.42 -7.84 -0.43 1.13e-13 Type 2 diabetes; CESC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg03609598 chr5:56110824 MAP3K1 -0.5 -5.35 -0.31 1.9e-7 Initial pursuit acceleration; CESC cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg24846343 chr22:24311635 DDTL 0.42 5.61 0.33 5.11e-8 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs2228479 0.702 rs11649501 chr16:89850957 A/T cg06558623 chr16:89946397 TCF25 1.18 9.42 0.5 2.3e-18 Skin colour saturation; CESC cis rs765787 0.530 rs3759893 chr15:45542950 G/T cg24006582 chr15:45444508 DUOX1 -0.6 -7.38 -0.41 2.07e-12 Uric acid levels; CESC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.39 0.41 1.97e-12 Electroencephalogram traits; CESC cis rs80130819 0.688 rs10783233 chr12:48590899 C/G cg05342945 chr12:48394962 COL2A1 -0.51 -5.81 -0.34 1.75e-8 Prostate cancer; CESC cis rs7582720 1.000 rs72934749 chr2:203746816 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs701145 0.617 rs9820619 chr3:154028294 G/T cg16511985 chr3:153974050 SGEF 0.4 5.33 0.31 2.06e-7 Coronary artery disease; CESC cis rs10838687 0.673 rs77532017 chr11:47284317 C/T cg25783544 chr11:47291846 MADD 0.58 6.58 0.37 2.5e-10 Proinsulin levels; CESC cis rs7551222 0.752 rs11240758 chr1:204528651 C/T cg20240347 chr1:204465584 NA -0.28 -5.61 -0.33 5.06e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09368168 chr16:15744041 NDE1 0.54 6.14 0.35 2.97e-9 Gut microbiome composition (summer); CESC cis rs6693567 0.565 rs1260458 chr1:150347454 C/T cg09579323 chr1:150459698 TARS2 0.46 6.05 0.35 4.93e-9 Migraine; CESC cis rs7809950 0.637 rs3801964 chr7:106836242 T/C cg23024343 chr7:107201750 COG5 -0.57 -6.94 -0.39 2.95e-11 Coronary artery disease; CESC cis rs2760061 0.626 rs2313118 chr1:228118084 T/C cg02753203 chr1:228287806 NA -0.5 -7.24 -0.41 4.91e-12 Diastolic blood pressure; CESC cis rs4722166 0.630 rs12700391 chr7:22777327 C/A cg05265849 chr7:22767390 IL6 0.57 7.11 0.4 1.06e-11 Lung cancer; CESC cis rs61996546 0.622 rs11637029 chr15:26836107 T/A cg14859324 chr15:26874363 GABRB3 -0.38 -5.12 -0.3 6e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs9911578 1.000 rs304296 chr17:56834229 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.16 0.3 4.76e-7 Intelligence (multi-trait analysis); CESC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg12463550 chr7:65579703 CRCP 0.58 7.41 0.41 1.67e-12 Aortic root size; CESC cis rs11997175 0.550 rs7459565 chr8:33836717 C/T ch.8.33884649F chr8:33765107 NA 0.58 6.66 0.38 1.58e-10 Body mass index; CESC cis rs7772486 0.875 rs9390372 chr6:146363638 G/C cg05347473 chr6:146136440 FBXO30 0.47 6.16 0.35 2.66e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg05564831 chr3:52568323 NT5DC2 0.43 6.59 0.38 2.3e-10 Bipolar disorder; CESC cis rs6424115 0.830 rs2503002 chr1:24196957 C/G cg10978503 chr1:24200527 CNR2 0.3 6.11 0.35 3.57e-9 Immature fraction of reticulocytes; CESC cis rs6665290 0.904 rs3768425 chr1:227178127 A/G cg10327440 chr1:227177885 CDC42BPA -1.23 -34.55 -0.9 3.8e-100 Myeloid white cell count; CESC cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg05347473 chr6:146136440 FBXO30 0.72 9.07 0.49 2.79e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs763121 0.853 rs6519124 chr22:39045099 T/C cg06022373 chr22:39101656 GTPBP1 0.95 17.36 0.73 1.37e-45 Menopause (age at onset); CESC cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg05347473 chr6:146136440 FBXO30 0.64 8.16 0.45 1.37e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs10911363 0.573 rs2702181 chr1:183516985 T/A cg09173681 chr1:183549694 NCF2 0.53 7.72 0.43 2.39e-13 Systemic lupus erythematosus; CESC cis rs17376456 0.877 rs10044139 chr5:93407803 T/C cg21475434 chr5:93447410 FAM172A 0.83 7.31 0.41 3.14e-12 Diabetic retinopathy; CESC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg18876405 chr7:65276391 NA 0.48 6.32 0.36 1.08e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01953119 chr2:20425340 SDC1 -0.59 -6.59 -0.38 2.32e-10 Gut microbiome composition (summer); CESC cis rs4704187 0.617 rs1477936 chr5:74448502 T/A cg03227963 chr5:74354835 NA 0.3 5.5 0.32 8.75e-8 Response to amphetamines; CESC cis rs6598955 0.543 rs17163720 chr1:26549399 A/G cg04990556 chr1:26633338 UBXN11 -0.74 -8.25 -0.45 7.73e-15 Obesity-related traits; CESC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg05313129 chr8:58192883 C8orf71 -0.4 -5.11 -0.3 6.17e-7 Developmental language disorder (linguistic errors); CESC cis rs11249608 0.789 rs903989 chr5:178434434 C/T cg21905437 chr5:178450457 ZNF879 0.55 7.85 0.43 1.05e-13 Pubertal anthropometrics; CESC cis rs11785400 0.928 rs2280878 chr8:143722366 G/A cg10596483 chr8:143751796 JRK 0.41 5.36 0.31 1.82e-7 Schizophrenia; CESC cis rs7914558 0.966 rs2297786 chr10:104679978 C/T cg08650961 chr10:104748594 CNNM2 0.32 5.12 0.3 5.79e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg07701084 chr6:150067640 NUP43 0.44 5.94 0.34 8.85e-9 Lung cancer; CESC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg01448562 chr3:133502909 NA -0.57 -7.84 -0.43 1.12e-13 Iron status biomarkers; CESC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg22920501 chr2:26401640 FAM59B -0.67 -8.09 -0.44 2.22e-14 Gut microbiome composition (summer); CESC cis rs9611565 0.506 rs1984839 chr22:41685937 G/C cg06634786 chr22:41940651 POLR3H -0.51 -5.48 -0.32 1.01e-7 Vitiligo; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18076651 chr12:53625605 RARG 0.41 6.45 0.37 5.26e-10 Systemic lupus erythematosus; CESC cis rs7116495 1.000 rs2508858 chr11:71805405 C/G cg26138937 chr11:71823887 C11orf51 0.85 6.82 0.39 6e-11 Severe influenza A (H1N1) infection; CESC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg18252515 chr7:66147081 NA 0.43 5.73 0.33 2.67e-8 Aortic root size; CESC trans rs10776614 0.799 rs7087729 chr10:49767103 C/T cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 10.92 0.56 3.56e-23 Personality dimensions; CESC cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg18357645 chr12:58087776 OS9 -0.42 -5.84 -0.34 1.49e-8 Multiple sclerosis; CESC cis rs8114671 0.836 rs734308 chr20:33572096 A/G cg24642439 chr20:33292090 TP53INP2 -0.46 -5.48 -0.32 1.01e-7 Height; CESC trans rs11989744 0.843 rs10481331 chr8:23559257 T/C cg03492747 chr16:86543808 FOXF1 0.64 7.29 0.41 3.59e-12 Waist-hip ratio; CESC cis rs7098414 0.511 rs7899545 chr10:82150635 G/C cg00277334 chr10:82204260 NA -0.5 -7.5 -0.42 9.84e-13 Post bronchodilator FEV1; CESC cis rs4803468 1.000 rs8105833 chr19:41896145 G/A cg14132834 chr19:41945861 ATP5SL -0.56 -6.89 -0.39 4.02e-11 Height; CESC cis rs7098414 0.511 rs7071752 chr10:82159539 C/A cg00277334 chr10:82204260 NA -0.52 -7.71 -0.43 2.58e-13 Post bronchodilator FEV1; CESC cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg20503657 chr10:835505 NA 0.63 7.11 0.4 1.06e-11 Eosinophil percentage of granulocytes; CESC cis rs6546550 0.933 rs1454498 chr2:70149225 C/A cg02498382 chr2:70120550 SNRNP27 -0.41 -7.26 -0.41 4.34e-12 Prevalent atrial fibrillation; CESC trans rs11098499 0.697 rs4560394 chr4:120313435 T/G cg25214090 chr10:38739885 LOC399744 0.68 9.21 0.49 1.05e-17 Corneal astigmatism; CESC cis rs7520050 0.807 rs28844317 chr1:46209207 T/C cg06784218 chr1:46089804 CCDC17 0.33 5.94 0.34 9.01e-9 Red blood cell count;Reticulocyte count; CESC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg11890956 chr21:40555474 PSMG1 1.09 18.21 0.75 1.28e-48 Cognitive function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05354989 chr17:56429503 SUPT4H1 0.45 6.03 0.35 5.37e-9 Gut microbiota (bacterial taxa); CESC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg04025307 chr7:1156635 C7orf50 0.48 7.69 0.43 2.81e-13 Longevity;Endometriosis; CESC cis rs12477438 0.501 rs11692336 chr2:99740606 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 12.74 0.62 2.5e-29 Chronic sinus infection; CESC cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs13064411 0.735 rs7636128 chr3:113133701 A/T cg18753928 chr3:113234510 CCDC52 -0.48 -5.75 -0.33 2.39e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs914615 0.529 rs11264338 chr1:155138557 A/G cg02153340 chr1:155202674 NA -0.38 -5.48 -0.32 9.97e-8 Urinary albumin-to-creatinine ratio; CESC cis rs4975616 0.804 rs31489 chr5:1342714 C/A cg26373071 chr5:1325741 CLPTM1L 0.46 7.16 0.4 8.04e-12 Lung cancer; CESC cis rs7264396 0.563 rs3827029 chr20:34332784 G/T cg23207816 chr20:34252616 CPNE1;RBM12 -0.64 -7.19 -0.4 6.64e-12 Total cholesterol levels; CESC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Depression; CESC cis rs1707322 1.000 rs1622208 chr1:46498375 A/G cg03146154 chr1:46216737 IPP -0.77 -10.51 -0.54 7.99e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.01 0.35 6.19e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.46 -0.5 1.79e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7680126 0.633 rs887732 chr4:10183117 G/C cg00071950 chr4:10020882 SLC2A9 -0.51 -5.55 -0.32 6.79e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs854765 0.693 rs4924823 chr17:17764502 A/G cg09796270 chr17:17721594 SREBF1 -0.4 -5.6 -0.33 5.27e-8 Total body bone mineral density; CESC cis rs1879734 0.773 rs1554750 chr1:54135334 T/C cg23596471 chr1:54105337 GLIS1 0.35 5.44 0.32 1.19e-7 Mitral valve prolapse; CESC trans rs877282 0.898 rs12359731 chr10:759497 A/G cg22713356 chr15:30763199 NA 1.12 11.1 0.56 8.99e-24 Uric acid levels; CESC cis rs367943 0.966 rs364738 chr5:112808329 A/G cg12552261 chr5:112820674 MCC -0.62 -7.85 -0.43 1.05e-13 Type 2 diabetes; CESC cis rs2228479 0.541 rs9922515 chr16:89954138 G/C cg06558623 chr16:89946397 TCF25 0.58 5.86 0.34 1.34e-8 Skin colour saturation; CESC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg06420487 chr17:61919686 SMARCD2 0.44 5.28 0.31 2.68e-7 Height; CESC cis rs6430585 0.528 rs2278682 chr2:136743143 G/C cg07169764 chr2:136633963 MCM6 1.09 15.1 0.68 1.35e-37 Corneal structure; CESC cis rs826838 0.967 rs1719856 chr12:39127201 C/T cg26384229 chr12:38710491 ALG10B -0.67 -10.95 -0.56 2.81e-23 Heart rate; CESC cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg22467129 chr15:76604101 ETFA -0.39 -5.79 -0.33 2.02e-8 Blood metabolite levels; CESC cis rs3809566 1.000 rs4775612 chr15:63332157 T/C cg05507819 chr15:63340323 TPM1 0.51 6.28 0.36 1.37e-9 Platelet count; CESC cis rs8060686 0.565 rs4359427 chr16:68202747 C/T cg26727032 chr16:67993705 SLC12A4 -0.49 -5.98 -0.34 7.1e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs546131 1.000 rs546131 chr11:34851760 G/C cg06937548 chr11:34938143 PDHX;APIP 0.5 6.22 0.36 1.93e-9 Lung disease severity in cystic fibrosis; CESC cis rs6570726 0.935 rs409121 chr6:145839793 G/A cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.36e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs1801251 1.000 rs13013142 chr2:233600606 A/G cg08000102 chr2:233561755 GIGYF2 0.67 9.36 0.5 3.68e-18 Coronary artery disease; CESC cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg18180107 chr4:99064573 C4orf37 0.42 5.23 0.31 3.45e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8133932 0.608 rs373267 chr21:47343320 G/T cg14185626 chr21:47401492 COL6A1 -0.46 -5.17 -0.3 4.62e-7 Schizophrenia; CESC cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs7937682 0.562 rs955744 chr11:111374334 C/T cg09085632 chr11:111637200 PPP2R1B 0.66 8.39 0.46 2.87e-15 Primary sclerosing cholangitis; CESC trans rs801193 1.000 rs1553609 chr7:66197139 T/C cg26939375 chr7:64535504 NA 0.64 8.67 0.47 4.39e-16 Aortic root size; CESC cis rs9291683 0.609 rs12500810 chr4:10031068 G/A cg00071950 chr4:10020882 SLC2A9 0.88 16.3 0.71 7.52e-42 Bone mineral density; CESC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg10691866 chr7:65817282 TPST1 0.34 5.58 0.32 6.03e-8 Aortic root size; CESC cis rs4253772 0.637 rs8139035 chr22:46651367 A/G cg24881330 chr22:46731750 TRMU 0.89 10.09 0.53 1.86e-20 LDL cholesterol;Cholesterol, total; CESC cis rs898097 0.841 rs8074284 chr17:80909967 G/A cg19046167 chr17:80928561 B3GNTL1 0.43 5.25 0.31 3.13e-7 Breast cancer; CESC cis rs9926296 0.533 rs12102297 chr16:89812762 C/A cg04287289 chr16:89883240 FANCA 0.92 16.38 0.71 3.91e-42 Vitiligo; CESC cis rs3126085 0.935 rs11588174 chr1:152175970 C/T cg26876637 chr1:152193138 HRNR -0.45 -5.21 -0.31 3.73e-7 Atopic dermatitis; CESC cis rs60154123 0.505 rs115881613 chr1:210040369 C/T cg25204440 chr1:209979598 IRF6 0.67 6.11 0.35 3.54e-9 Coronary artery disease; CESC cis rs1707322 0.963 rs9787412 chr1:46371596 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg02269571 chr22:50332266 NA -0.57 -6.99 -0.39 2.29e-11 Schizophrenia; CESC cis rs1348850 0.757 rs4893969 chr2:178478476 T/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.53 6.82 0.39 5.99e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2635047 0.648 rs4986203 chr18:44597092 A/G cg19077165 chr18:44547161 KATNAL2 -0.52 -7.51 -0.42 8.81e-13 Educational attainment; CESC cis rs4474465 0.688 rs7929656 chr11:78276416 T/C cg27205649 chr11:78285834 NARS2 0.47 6.35 0.36 9.35e-10 Alzheimer's disease (survival time); CESC cis rs400736 0.562 rs12129505 chr1:8171734 T/C cg25007680 chr1:8021821 PARK7 -0.6 -7.81 -0.43 1.32e-13 Response to antidepressants and depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04407228 chr1:1710158 NADK 0.6 6.36 0.36 8.77e-10 Gut microbiome composition (summer); CESC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg13880726 chr7:1868755 MAD1L1 0.51 6.98 0.39 2.4e-11 Bipolar disorder and schizophrenia; CESC cis rs9911578 1.000 rs7342903 chr17:56914588 C/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis); CESC cis rs6963495 0.818 rs73192120 chr7:105171156 C/T cg19920283 chr7:105172520 RINT1 0.69 6.54 0.37 3.15e-10 Bipolar disorder (body mass index interaction); CESC trans rs526821 0.595 rs629948 chr11:55356448 G/A cg15704280 chr7:45808275 SEPT13 -0.52 -6.55 -0.37 2.99e-10 Pediatric bone mineral density (spine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11957880 chr12:93835939 UBE2N -0.6 -6.89 -0.39 4.14e-11 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg03609598 chr5:56110824 MAP3K1 -0.5 -5.32 -0.31 2.26e-7 Initial pursuit acceleration; CESC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.69 10.17 0.53 9.75e-21 Menarche (age at onset); CESC cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00746083 chr14:21905454 CHD8 0.48 6.4 0.37 7.2e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02073954 chr6:28193080 ZNF193 -0.54 -6.87 -0.39 4.52e-11 Ulcerative colitis; CESC cis rs1348850 0.914 rs10170546 chr2:178248790 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.9 13.34 0.63 2.15e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11098499 0.821 rs3775852 chr4:120454556 A/G cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg16049864 chr8:95962084 TP53INP1 -0.61 -10.57 -0.54 5.24e-22 Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24117723 chr11:77185398 PAK1 -0.46 -6.0 -0.35 6.56e-9 Fibrinogen levels; CESC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg24829409 chr8:58192753 C8orf71 -0.56 -7.04 -0.4 1.61e-11 Developmental language disorder (linguistic errors); CESC cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg24296786 chr1:45957014 TESK2 0.64 8.63 0.47 5.88e-16 High light scatter reticulocyte count; CESC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg18032046 chr6:28092343 ZSCAN16 -0.47 -6.05 -0.35 4.86e-9 Parkinson's disease; CESC cis rs2073300 1.000 rs114718317 chr20:23442620 T/C cg12062639 chr20:23401060 NAPB 0.9 6.28 0.36 1.4e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.71 0.38 1.17e-10 Platelet count; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg18099408 chr3:52552593 STAB1 -0.38 -6.87 -0.39 4.69e-11 Hemoglobin concentration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07855967 chr6:13486425 C6orf114;GFOD1 -0.44 -6.91 -0.39 3.68e-11 Gambling; CESC cis rs9467711 0.606 rs9393708 chr6:26362643 C/T cg14345882 chr6:26364793 BTN3A2 -0.61 -6.72 -0.38 1.11e-10 Autism spectrum disorder or schizophrenia; CESC cis rs2066819 1.000 rs57279772 chr12:56698960 G/A cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg09365446 chr1:150670422 GOLPH3L 0.41 5.58 0.32 5.85e-8 Melanoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25934700 chr22:50644755 SELO -0.56 -6.43 -0.37 5.93e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15983200 chr12:110562122 IFT81 0.56 6.37 0.36 8.35e-10 Gut microbiome composition (summer); CESC cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg15556689 chr8:8085844 FLJ10661 0.53 6.45 0.37 5.4e-10 Mood instability; CESC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg18337363 chr3:52569053 NT5DC2 0.29 5.2 0.3 4e-7 Electroencephalogram traits; CESC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.4e-8 Developmental language disorder (linguistic errors); CESC cis rs3733585 0.699 rs7676733 chr4:9966956 G/A cg11266682 chr4:10021025 SLC2A9 -0.58 -10.94 -0.56 3.03e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10779751 0.770 rs11581010 chr1:11212458 A/G cg08854313 chr1:11322531 MTOR -0.73 -8.44 -0.46 2.06e-15 Body mass index; CESC trans rs9325144 0.647 rs7487395 chr12:38865660 C/A cg23762105 chr12:34175262 ALG10 0.46 6.04 0.35 5.3e-9 Morning vs. evening chronotype; CESC cis rs3796352 1.000 rs10510761 chr3:52965255 A/G cg12962167 chr3:53033115 SFMBT1 -0.59 -5.1 -0.3 6.53e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs12478296 0.901 rs67951957 chr2:243004901 A/G cg06360820 chr2:242988706 NA -0.74 -9.12 -0.49 1.92e-17 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18849300 chr3:48723061 NCKIPSD 0.5 6.3 0.36 1.27e-9 Gut microbiome composition (summer); CESC cis rs4319547 0.620 rs12372756 chr12:122815130 A/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -5.6 -0.33 5.34e-8 Body mass index; CESC cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12911832 0.958 rs12912003 chr15:58986001 A/T cg05156742 chr15:59063176 FAM63B 0.57 7.14 0.4 8.75e-12 Schizophrenia; CESC cis rs3806843 0.966 rs11953833 chr5:140155123 T/A cg26395211 chr5:140044315 WDR55 -0.4 -5.15 -0.3 5.05e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9911578 1.000 rs2270097 chr17:56572070 G/A cg05425664 chr17:57184151 TRIM37 0.49 6.83 0.39 5.65e-11 Intelligence (multi-trait analysis); CESC trans rs2727020 0.553 rs3862350 chr11:49595912 A/C cg15704280 chr7:45808275 SEPT13 -0.95 -16.23 -0.71 1.34e-41 Coronary artery disease; CESC cis rs6460942 1.000 rs6460935 chr7:12401317 A/T cg17427002 chr7:12443146 VWDE -0.51 -5.04 -0.3 8.8e-7 Coronary artery disease; CESC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg05535760 chr7:792225 HEATR2 0.97 11.19 0.57 4.78e-24 Cerebrospinal P-tau181p levels; CESC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg25985355 chr7:65971099 NA -0.31 -5.04 -0.3 8.47e-7 Aortic root size; CESC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg07677032 chr17:61819896 STRADA 0.45 5.96 0.34 8.12e-9 Prudent dietary pattern; CESC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg18538332 chr22:24372958 LOC391322 0.72 10.22 0.53 6.92e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7680126 0.644 rs4697703 chr4:10107431 A/G cg11266682 chr4:10021025 SLC2A9 -0.53 -7.28 -0.41 3.77e-12 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs10242455 0.764 rs4646465 chr7:99304524 A/G cg07715041 chr7:99302981 CYP3A7 -0.42 -5.37 -0.31 1.71e-7 Blood metabolite levels; CESC cis rs2180341 0.960 rs9398839 chr6:127665863 G/A cg24812749 chr6:127587940 RNF146 1.07 15.17 0.68 7.85e-38 Breast cancer; CESC cis rs17401966 0.838 rs11580854 chr1:10293565 G/A cg15208524 chr1:10270712 KIF1B 0.41 5.36 0.31 1.84e-7 Hepatocellular carcinoma; CESC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.13 0.3 5.51e-7 Menopause (age at onset); CESC cis rs1144333 1.000 rs12078893 chr1:76370862 T/C cg10523679 chr1:76189770 ACADM 0.56 5.19 0.3 4.09e-7 Attention function in attention deficit hyperactive disorder; CESC trans rs7937682 0.961 rs7106104 chr11:111635655 T/C cg18187862 chr3:45730750 SACM1L -0.55 -6.2 -0.36 2.1e-9 Primary sclerosing cholangitis; CESC cis rs60154123 0.686 rs227222 chr1:210191272 T/C cg22029157 chr1:209979665 IRF6 -0.62 -5.24 -0.31 3.26e-7 Coronary artery disease; CESC cis rs6728642 1.000 rs60608738 chr2:97608085 G/A cg26665480 chr2:98280029 ACTR1B -0.65 -6.44 -0.37 5.72e-10 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs17209837 0.920 rs17149652 chr7:87087187 G/T cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC cis rs1670533 0.932 rs13140571 chr4:1054358 T/C cg27284194 chr4:1044797 NA 0.46 5.83 0.34 1.61e-8 Recombination rate (females); CESC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg23978390 chr7:1156363 C7orf50 -0.62 -8.9 -0.48 8.83e-17 Longevity;Endometriosis; CESC cis rs7044106 0.718 rs1981021 chr9:123388393 T/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.84 0.34 1.54e-8 Hip circumference adjusted for BMI; CESC trans rs3780486 0.629 rs10971439 chr9:33180813 C/T cg20290983 chr6:43655470 MRPS18A -0.57 -6.46 -0.37 4.93e-10 IgG glycosylation; CESC cis rs10744422 1.000 rs7294991 chr12:123286780 C/T cg22842854 chr12:123319900 HIP1R -0.61 -5.09 -0.3 6.95e-7 Schizophrenia; CESC cis rs4654899 1.000 rs10916921 chr1:21334542 C/T cg05370193 chr1:21551575 ECE1 0.41 6.25 0.36 1.63e-9 Superior frontal gyrus grey matter volume; CESC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg18446336 chr7:2847575 GNA12 -0.35 -5.52 -0.32 8.23e-8 Height; CESC cis rs854765 0.693 rs35451946 chr17:17764061 C/G cg04398451 chr17:18023971 MYO15A 0.64 9.36 0.5 3.58e-18 Total body bone mineral density; CESC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg04166393 chr7:2884313 GNA12 0.6 7.63 0.42 4.2e-13 Height; CESC cis rs59698941 0.765 rs67045943 chr5:132219956 C/T cg02081065 chr5:132209139 LEAP2 -0.52 -5.11 -0.3 6.08e-7 Apolipoprotein A-IV levels; CESC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg26335602 chr6:28129616 ZNF389 0.53 6.75 0.38 9.35e-11 Parkinson's disease; CESC cis rs2797160 0.967 rs926854 chr6:126021780 A/G cg05901451 chr6:126070800 HEY2 0.45 6.51 0.37 3.77e-10 Endometrial cancer; CESC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg26338869 chr17:61819248 STRADA 0.69 9.2 0.49 1.12e-17 Prudent dietary pattern; CESC cis rs8058578 1.000 rs56656810 chr16:30788759 C/A cg00531865 chr16:30841666 NA -0.43 -5.5 -0.32 8.79e-8 Multiple myeloma; CESC cis rs10779751 0.770 rs10864490 chr1:11236410 A/C cg08854313 chr1:11322531 MTOR 0.78 9.97 0.52 4.23e-20 Body mass index; CESC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.75 0.81 2.95e-64 Prudent dietary pattern; CESC trans rs8073060 0.586 rs72829922 chr17:34044809 G/A cg19694781 chr19:47549865 TMEM160 0.72 6.47 0.37 4.78e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs4555082 1.000 rs4277291 chr14:105759009 A/G cg06808227 chr14:105710500 BRF1 -0.52 -6.31 -0.36 1.16e-9 Mean platelet volume;Platelet distribution width; CESC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg21285383 chr16:89894308 SPIRE2 0.31 5.4 0.32 1.46e-7 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11604142 chr10:101989359 CHUK 0.64 6.89 0.39 3.96e-11 Gut microbiome composition (summer); CESC cis rs6752107 1.000 rs2241879 chr2:234183468 G/A cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.37 5.56 0.32 6.49e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs17539620 0.534 rs7768635 chr6:154827861 C/T cg17771515 chr6:154831774 CNKSR3 0.47 5.12 0.3 5.9e-7 Lipoprotein (a) levels; CESC cis rs921968 0.565 rs7580147 chr2:219643036 A/G cg02176678 chr2:219576539 TTLL4 -0.43 -7.73 -0.43 2.26e-13 Mean corpuscular hemoglobin concentration; CESC cis rs4727027 0.704 rs12704070 chr7:148902789 G/A cg23583168 chr7:148888333 NA -0.94 -17.36 -0.73 1.28e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2777491 1.000 rs66538814 chr15:41685917 G/T cg20272979 chr15:41787780 ITPKA 0.35 5.12 0.3 5.88e-7 Ulcerative colitis; CESC cis rs8078723 1.000 rs4795415 chr17:38157995 C/T cg17467752 chr17:38218738 THRA 0.69 10.55 0.54 5.78e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs7659604 0.502 rs28522256 chr4:122709266 C/T cg19671926 chr4:122722719 EXOSC9 0.67 8.89 0.48 9.9900000000000006e-17 Type 2 diabetes; CESC cis rs11098499 0.866 rs12501602 chr4:120287935 A/T cg09307838 chr4:120376055 NA 0.87 12.1 0.6 3.92e-27 Corneal astigmatism; CESC cis rs4604732 0.536 rs10925056 chr1:247650472 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.44 5.56 0.32 6.43e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs644148 0.785 rs118112019 chr19:44965091 T/G cg15540054 chr19:45004280 ZNF180 0.53 5.82 0.34 1.73e-8 Personality dimensions; CESC cis rs6087990 0.735 rs2424913 chr20:31374259 C/T cg13636640 chr20:31349939 DNMT3B 0.75 11.72 0.58 7.79e-26 Ulcerative colitis; CESC cis rs10788264 0.621 rs7907952 chr10:124056774 C/T cg09507567 chr10:124027408 NA -0.37 -5.5 -0.32 8.88e-8 Total body bone mineral density; CESC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg24675658 chr1:53192096 ZYG11B 0.53 6.78 0.38 7.96e-11 Monocyte count; CESC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg03452623 chr4:187889614 NA 0.9 16.64 0.71 4.64e-43 Lobe attachment (rater-scored or self-reported); CESC cis rs11785400 0.793 rs750530 chr8:143744931 G/A cg24634471 chr8:143751801 JRK 0.46 5.83 0.34 1.61e-8 Schizophrenia; CESC cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.43 5.66 0.33 3.98e-8 Personality dimensions; CESC cis rs137603 0.562 rs137644 chr22:39728139 A/G cg01093212 chr22:39715156 SNORD43;RPL3 -0.4 -5.16 -0.3 4.9e-7 Primary biliary cholangitis; CESC cis rs8072100 1.000 rs11870935 chr17:45732605 G/A cg08085267 chr17:45401833 C17orf57 0.42 5.63 0.33 4.55e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9291683 0.632 rs13137074 chr4:10042842 C/T cg02734326 chr4:10020555 SLC2A9 0.47 6.53 0.37 3.29e-10 Bone mineral density; CESC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.33 0.31 2.11e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19791277 chr8:136469780 KHDRBS3 -0.55 -6.31 -0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs6570726 0.791 rs7765687 chr6:145915100 A/C cg05347473 chr6:146136440 FBXO30 0.52 6.83 0.39 5.79e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg05340658 chr4:99064831 C4orf37 -0.82 -12.78 -0.62 1.89e-29 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.623 rs9890558 chr17:29110355 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs16957304 1.000 rs9924145 chr16:67329762 T/C cg26727032 chr16:67993705 SLC12A4 -0.52 -5.18 -0.3 4.42e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs4965006 0.915 rs4965004 chr12:132424700 A/G cg00588090 chr12:132412438 PUS1 0.52 7.12 0.4 1.01e-11 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs8180040 0.653 rs6808742 chr3:47051512 G/A cg27129171 chr3:47204927 SETD2 0.68 9.98 0.52 4.14e-20 Colorectal cancer; CESC cis rs3106136 0.967 rs2664892 chr4:95154186 T/C cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.25 -0.41 4.57e-12 Capecitabine sensitivity; CESC cis rs2777491 0.957 rs919961 chr15:41651721 A/G cg18705301 chr15:41695430 NDUFAF1 -0.62 -9.39 -0.5 2.92e-18 Ulcerative colitis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00307073 chr7:116502428 CAPZA2 0.52 6.9 0.39 3.78e-11 Systemic lupus erythematosus; CESC cis rs10864907 0.614 rs10199311 chr2:113697961 C/T cg12858261 chr2:113808755 IL1F8 0.45 5.48 0.32 9.88e-8 Pulmonary function; CESC cis rs4843747 0.749 rs13333619 chr16:88072076 C/T cg09044154 chr16:88155775 NA -0.45 -5.05 -0.3 8.33e-7 Menopause (age at onset); CESC cis rs944722 0.511 rs2297520 chr17:26108040 T/C cg07704981 chr17:26127537 NOS2 -0.35 -5.36 -0.31 1.78e-7 Fractional exhaled nitric oxide (childhood); CESC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg13175981 chr1:150552382 MCL1 0.62 9.22 0.49 9.37e-18 Tonsillectomy; CESC cis rs1707322 1.000 rs4660895 chr1:46329739 C/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg11644478 chr21:40555479 PSMG1 0.95 14.26 0.66 1.25e-34 Cognitive function; CESC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg19163074 chr7:65112434 INTS4L2 -0.41 -5.11 -0.3 6.29e-7 Aortic root size; CESC cis rs4835473 0.832 rs35763177 chr4:144658870 A/T cg25736465 chr4:144833511 NA -0.33 -5.2 -0.3 4.08e-7 Immature fraction of reticulocytes; CESC cis rs561341 1.000 rs473356 chr17:30321762 G/C cg23018236 chr17:30244563 NA -0.52 -5.11 -0.3 6.12e-7 Hip circumference adjusted for BMI; CESC cis rs5758659 0.652 rs133300 chr22:42389839 A/G cg04733989 chr22:42467013 NAGA 0.46 6.13 0.35 3.12e-9 Cognitive function; CESC cis rs11112613 0.713 rs60865625 chr12:105940256 A/C cg03607813 chr12:105948248 NA 0.66 7.95 0.44 5.32e-14 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs847577 0.569 rs12674083 chr7:97696334 C/T cg24562669 chr7:97807699 LMTK2 0.78 13.15 0.63 9.73e-31 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09149896 chr17:48624438 SPATA20 0.56 6.59 0.38 2.32e-10 Gut microbiome composition (summer); CESC cis rs11638352 1.000 rs2059628 chr15:44415271 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.51 0.42 8.95e-13 Prudent dietary pattern; CESC cis rs7568498 0.517 rs11678856 chr2:161925443 C/T cg08807892 chr2:162101083 NA -0.52 -5.74 -0.33 2.53e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs727505 0.551 rs2293346 chr7:124783849 C/T cg23710748 chr7:124431027 NA -0.34 -5.54 -0.32 7.18e-8 Lewy body disease; CESC cis rs9911578 0.835 rs3744093 chr17:56492800 T/C cg12560992 chr17:57184187 TRIM37 -0.88 -14.33 -0.66 7.21e-35 Intelligence (multi-trait analysis); CESC cis rs3820928 0.874 rs2396452 chr2:227838040 T/G cg11843606 chr2:227700838 RHBDD1 -0.51 -6.65 -0.38 1.64e-10 Pulmonary function; CESC cis rs6963495 0.818 rs73190202 chr7:105166510 A/G cg02135003 chr7:105160482 PUS7 -0.46 -5.51 -0.32 8.38e-8 Bipolar disorder (body mass index interaction); CESC cis rs2243480 1.000 rs6460261 chr7:65215580 T/C cg25894440 chr7:65020034 NA 0.65 5.42 0.32 1.36e-7 Diabetic kidney disease; CESC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg16405210 chr4:1374714 KIAA1530 -0.71 -9.36 -0.5 3.61e-18 Longevity; CESC cis rs593982 0.777 rs534414 chr11:65475515 A/G cg08755490 chr11:65554678 OVOL1 1.17 10.74 0.55 1.45e-22 Atopic dermatitis; CESC cis rs7267979 0.868 rs6107019 chr20:25233985 C/T cg08601574 chr20:25228251 PYGB 0.42 5.91 0.34 1.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs6460942 0.643 rs80264734 chr7:12233800 T/A cg06484146 chr7:12443880 VWDE -0.47 -5.22 -0.31 3.54e-7 Coronary artery disease; CESC cis rs9875589 0.509 rs4047237 chr3:14012861 T/C cg19554555 chr3:13937349 NA -0.44 -5.61 -0.33 5.2e-8 Ovarian reserve; CESC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg18252515 chr7:66147081 NA -0.43 -5.73 -0.33 2.67e-8 Aortic root size; CESC cis rs7777484 0.534 rs2533886 chr7:2834869 C/T cg19717773 chr7:2847554 GNA12 -0.68 -11.72 -0.58 7.98e-26 Height; CESC cis rs12410462 0.579 rs115037090 chr1:227666191 A/G cg23173402 chr1:227635558 NA 0.71 6.11 0.35 3.57e-9 Major depressive disorder; CESC cis rs72634258 0.945 rs3766606 chr1:8022197 G/T cg00042356 chr1:8021962 PARK7 0.71 6.91 0.39 3.59e-11 Inflammatory bowel disease; CESC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs6582630 0.537 rs11611326 chr12:38547958 C/A cg26384229 chr12:38710491 ALG10B 0.72 10.77 0.55 1.13e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs3767633 0.925 rs924777 chr1:161848904 G/A cg09175582 chr1:161736000 ATF6 0.86 6.95 0.39 2.83e-11 IgG glycosylation; CESC cis rs116095464 0.558 rs11959126 chr5:283880 T/G cg20965017 chr5:231967 SDHA -0.46 -5.2 -0.3 4.02e-7 Breast cancer; CESC cis rs8058578 1.000 rs8051050 chr16:30687909 A/G cg00531865 chr16:30841666 NA -0.43 -5.58 -0.32 6.02e-8 Multiple myeloma; CESC cis rs10207060 0.771 rs4852124 chr2:240680022 C/T cg07506560 chr2:240697449 NA 0.41 5.78 0.33 2.13e-8 Obesity-related traits; CESC cis rs7809950 1.000 rs10234355 chr7:107086517 T/G cg23024343 chr7:107201750 COG5 -0.41 -5.89 -0.34 1.2e-8 Coronary artery disease; CESC cis rs4699052 0.625 rs11734572 chr4:104288620 G/A cg16532752 chr4:104119610 CENPE -0.37 -5.28 -0.31 2.72e-7 Testicular germ cell tumor; CESC cis rs4629180 0.959 rs11896771 chr2:102098328 T/C cg04415270 chr2:102091202 RFX8 -0.42 -7.07 -0.4 1.39e-11 Chronic rhinosinusitis with nasal polyps; CESC cis rs9910055 0.664 rs433610 chr17:42197281 A/G cg08499158 chr17:42289980 UBTF 0.58 7.63 0.42 4.33e-13 Total body bone mineral density; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.42 8.24 0.45 8.2e-15 Electroencephalogram traits; CESC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg20243544 chr17:37824526 PNMT -0.48 -6.07 -0.35 4.42e-9 Glomerular filtration rate (creatinine); CESC cis rs854765 0.575 rs2955357 chr17:17946401 T/C cg16928487 chr17:17741425 SREBF1 0.56 9.38 0.5 3e-18 Total body bone mineral density; CESC cis rs2011503 0.943 rs8100927 chr19:19643636 C/G cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs453301 0.624 rs2288671 chr8:8860894 T/C cg15556689 chr8:8085844 FLJ10661 0.46 5.8 0.34 1.88e-8 Joint mobility (Beighton score); CESC cis rs4906332 0.782 rs2236281 chr14:104000518 G/T cg19000871 chr14:103996768 TRMT61A -0.35 -5.09 -0.3 6.83e-7 Coronary artery disease; CESC cis rs4604732 0.588 rs7549955 chr1:247628321 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.09 0.3 6.91e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12188164 0.620 rs56070387 chr5:482531 A/T cg15813090 chr5:442598 EXOC3;C5orf55 0.42 5.97 0.34 7.67e-9 Cystic fibrosis severity; CESC cis rs116095464 0.558 rs6881920 chr5:222411 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.74 0.33 2.63e-8 Breast cancer; CESC cis rs13191362 0.935 rs13205279 chr6:162945030 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.73 6.37 0.36 8.54e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6499255 1.000 rs11641521 chr16:69823081 C/G cg15192750 chr16:69999425 NA 0.45 5.51 0.32 8.31e-8 IgE levels; CESC cis rs9303401 0.659 rs12602808 chr17:56698420 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.13 0.63 1.12e-30 Cognitive test performance; CESC cis rs1729951 0.575 rs1682356 chr3:136692037 T/C cg15507776 chr3:136538369 TMEM22 0.41 5.11 0.3 6.29e-7 Neuroticism; CESC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg05313129 chr8:58192883 C8orf71 -0.56 -6.51 -0.37 3.67e-10 Developmental language disorder (linguistic errors); CESC cis rs1577917 1.000 rs1857965 chr6:86630776 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.33 2.14e-8 Response to antipsychotic treatment; CESC cis rs7772486 0.754 rs6921073 chr6:146144377 G/A cg05347473 chr6:146136440 FBXO30 0.54 6.96 0.39 2.63e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs62229266 0.771 rs7280136 chr21:37432910 C/G cg08632701 chr21:37451849 NA 0.37 5.1 0.3 6.36e-7 Mitral valve prolapse; CESC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg14298792 chr15:30685198 CHRFAM7A 0.46 5.59 0.33 5.51e-8 Huntington's disease progression; CESC cis rs4737010 0.570 rs6474364 chr8:41646997 T/G cg08923054 chr8:41654455 ANK1 0.55 6.85 0.39 5.18e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs7560272 0.723 rs6743576 chr2:73814333 G/A cg20560298 chr2:73613845 ALMS1 -0.51 -7.26 -0.41 4.35e-12 Schizophrenia; CESC cis rs12410462 0.901 rs1120000 chr1:227659615 T/C cg23173402 chr1:227635558 NA 0.56 5.67 0.33 3.72e-8 Major depressive disorder; CESC cis rs258892 0.947 rs266443 chr5:72180377 C/T cg21869765 chr5:72125136 TNPO1 0.45 5.65 0.33 4.2e-8 Small cell lung carcinoma; CESC cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg05347473 chr6:146136440 FBXO30 0.59 7.63 0.42 4.24e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7647973 1.000 rs12583 chr3:49571462 G/T cg07636037 chr3:49044803 WDR6 -0.69 -9.6 -0.51 6.34e-19 Menarche (age at onset); CESC cis rs17039065 0.920 rs73838436 chr4:109446477 G/T cg16022748 chr4:109541635 LOC285456;RPL34 0.62 5.61 0.33 5.08e-8 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg12463550 chr7:65579703 CRCP -0.47 -6.01 -0.35 6.04e-9 Aortic root size; CESC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg09074113 chr2:20870087 GDF7 -0.43 -7.04 -0.4 1.66e-11 Abdominal aortic aneurysm; CESC cis rs6570726 0.967 rs9403707 chr6:145800010 A/G cg23711669 chr6:146136114 FBXO30 0.76 10.99 0.56 2.11e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs9549367 0.789 rs9549711 chr13:113900557 C/T cg18105134 chr13:113819100 PROZ -0.68 -8.25 -0.45 7.53e-15 Platelet distribution width; CESC cis rs6062302 0.522 rs3787107 chr20:62230576 G/A cg09650180 chr20:62225654 GMEB2 -0.82 -9.28 -0.5 6.08e-18 Glioblastoma; CESC cis rs10504073 0.669 rs4493917 chr8:50015846 C/T cg00325661 chr8:49890786 NA 0.57 8.6 0.47 7.15e-16 Blood metabolite ratios; CESC cis rs2455799 0.613 rs2470542 chr3:15724133 A/C cg16303742 chr3:15540471 COLQ -0.38 -5.83 -0.34 1.57e-8 Mean platelet volume; CESC cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg00080972 chr5:178986291 RUFY1 0.44 6.98 0.39 2.35e-11 Lung cancer; CESC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.97 10.21 0.53 7.3e-21 Platelet count; CESC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg13393036 chr8:95962371 TP53INP1 -0.55 -12.25 -0.6 1.25e-27 Type 2 diabetes; CESC cis rs2011503 0.941 rs11670775 chr19:19649636 A/G cg11584989 chr19:19387371 SF4 0.59 6.82 0.39 6.12e-11 Bipolar disorder; CESC cis rs13126513 0.519 rs7659550 chr4:100554402 G/T cg05468953 chr4:100565104 NA 0.34 5.24 0.31 3.34e-7 Metabolite levels (MHPG); CESC cis rs11792861 0.962 rs3829084 chr9:111801724 C/G cg05043794 chr9:111880884 C9orf5 0.41 6.84 0.39 5.37e-11 Menarche (age at onset); CESC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.25 0.53 5.71e-21 Prudent dietary pattern; CESC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.07e-8 Lung cancer; CESC trans rs9393777 0.841 rs13191474 chr6:27413345 C/T cg06606381 chr12:133084897 FBRSL1 -0.96 -7.42 -0.41 1.54e-12 Intelligence (multi-trait analysis); CESC cis rs4253311 0.520 rs7687818 chr4:187122060 A/G cg24794857 chr4:187113578 CYP4V2 0.43 5.67 0.33 3.82e-8 Plasma renin activity levels;Circulating chromogranin peptide levels;Blood metabolite levels; CESC cis rs12325245 0.536 rs35432891 chr16:58561966 G/A cg05725404 chr16:58534157 NDRG4 -0.61 -5.24 -0.31 3.21e-7 Schizophrenia; CESC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 5.9 0.34 1.11e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1878931 0.858 rs3760083 chr16:3450052 C/T cg22508957 chr16:3507546 NAT15 0.38 5.5 0.32 8.88e-8 Body mass index (adult); CESC cis rs17039065 0.920 rs72891053 chr4:109460871 C/T cg16022748 chr4:109541635 LOC285456;RPL34 0.66 6.19 0.36 2.27e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.918 rs2281333 chr22:41749630 T/C cg17376030 chr22:41985996 PMM1 0.43 5.03 0.3 9.05e-7 Vitiligo; CESC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -12.15 -0.6 2.74e-27 Alzheimer's disease; CESC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg25036284 chr2:26402008 FAM59B 0.71 8.3 0.45 5.3e-15 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17951368 chr11:17298273 NUCB2 0.46 6.13 0.35 3.22e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1008375 0.932 rs4698628 chr4:17608620 A/G cg27347728 chr4:17578864 LAP3 0.44 5.32 0.31 2.17e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs763121 0.853 rs3761454 chr22:39066820 C/T cg14440974 chr22:39074834 NA -0.42 -5.81 -0.34 1.75e-8 Menopause (age at onset); CESC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg11644478 chr21:40555479 PSMG1 0.96 14.03 0.65 8.35e-34 Cognitive function; CESC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg18446336 chr7:2847575 GNA12 -0.38 -5.8 -0.34 1.93e-8 Height; CESC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg12379764 chr21:47803548 PCNT 0.56 7.89 0.44 7.8500000000000006e-14 Testicular germ cell tumor; CESC cis rs4720575 1.000 rs7791050 chr7:47086452 T/C cg00036614 chr7:47093842 NA -0.43 -6.62 -0.38 2e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg00166722 chr3:10149974 C3orf24 0.52 6.61 0.38 2.15e-10 Alzheimer's disease; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg23461432 chr11:56457812 OR8U8 -0.59 -6.81 -0.39 6.44e-11 Psoriatic arthritis; CESC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.28 -0.36 1.34e-9 Total body bone mineral density; CESC cis rs4595586 0.545 rs11615638 chr12:39364766 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.57 0.42 6.23e-13 Morning vs. evening chronotype; CESC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg17158414 chr2:27665306 KRTCAP3 -0.35 -6.4 -0.37 7.17e-10 Total body bone mineral density; CESC cis rs62458065 0.513 rs7788809 chr7:32552622 T/A cg20159608 chr7:32802032 NA -0.56 -6.26 -0.36 1.54e-9 Metabolite levels (HVA/MHPG ratio); CESC cis rs10416265 0.527 rs7246814 chr19:33538414 G/T cg27124370 chr19:33622961 WDR88 0.54 7.41 0.41 1.68e-12 Bone properties (heel); CESC cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -6.68 -0.38 1.42e-10 Hemoglobin concentration; CESC cis rs7474896 0.616 rs2505239 chr10:38440765 A/G cg25427524 chr10:38739819 LOC399744 -0.51 -5.06 -0.3 7.89e-7 Obesity (extreme); CESC cis rs6942756 0.806 rs7788327 chr7:128986519 C/T cg02491457 chr7:128862824 NA -0.64 -9.09 -0.49 2.32e-17 White matter hyperintensity burden; CESC cis rs11645898 0.687 rs56129242 chr16:72098260 C/G cg14768367 chr16:72042858 DHODH -0.62 -5.33 -0.31 2.11e-7 Blood protein levels; CESC cis rs7116495 0.786 rs678193 chr11:71770273 A/C cg10381502 chr11:71823885 C11orf51 -0.67 -5.66 -0.33 3.92e-8 Severe influenza A (H1N1) infection; CESC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg12963246 chr6:28129442 ZNF389 0.39 5.57 0.32 6.24e-8 Parkinson's disease; CESC cis rs735396 0.770 rs2264782 chr12:121432603 C/T cg25281562 chr12:121454272 C12orf43 0.39 5.07 0.3 7.36e-7 N-glycan levels; CESC cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg06484146 chr7:12443880 VWDE -0.81 -9.25 -0.49 7.78e-18 Coronary artery disease; CESC cis rs7599312 0.534 rs10182996 chr2:213404834 T/C cg16329650 chr2:213403929 ERBB4 0.58 8.43 0.46 2.31e-15 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.82 8.2 0.45 1.06e-14 Platelet count; CESC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg06505273 chr16:24850292 NA -0.53 -6.49 -0.37 4.27e-10 Intelligence (multi-trait analysis); CESC cis rs2243480 0.901 rs778732 chr7:65822360 C/T cg13147721 chr7:65941812 NA -0.93 -8.5 -0.46 1.44e-15 Diabetic kidney disease; CESC cis rs8070128 0.568 rs3935505 chr17:17882020 T/G cg16928487 chr17:17741425 SREBF1 -0.56 -8.8 -0.48 1.84e-16 Total body bone mineral density; CESC cis rs2243480 1.000 rs34970380 chr7:65431493 C/T cg25894440 chr7:65020034 NA -0.66 -5.72 -0.33 2.81e-8 Diabetic kidney disease; CESC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg04944784 chr2:26401820 FAM59B -0.95 -11.61 -0.58 1.86e-25 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg02951883 chr7:2050386 MAD1L1 -0.46 -5.92 -0.34 9.71e-9 Bipolar disorder and schizophrenia; CESC cis rs4595586 0.545 rs12828001 chr12:39392208 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg24562669 chr7:97807699 LMTK2 0.48 7.0 0.4 2.09e-11 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25689539 chr7:149130015 ZNF777 -0.54 -6.19 -0.36 2.28e-9 Gut microbiome composition (summer); CESC cis rs2124969 0.562 rs6750639 chr2:161066862 T/C cg03641300 chr2:160917029 PLA2R1 -0.41 -5.84 -0.34 1.53e-8 Waist circumference adjusted for body mass index; CESC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg00129232 chr17:37814104 STARD3 -0.55 -7.12 -0.4 1.04e-11 Glomerular filtration rate (creatinine); CESC cis rs4604732 0.631 rs74154675 chr1:247625836 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7000551 0.700 rs2461480 chr8:22381839 C/T cg12081754 chr8:22256438 SLC39A14 0.45 5.99 0.35 6.93e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs561341 0.883 rs2074102 chr17:30228884 G/A cg12193833 chr17:30244370 NA -0.6 -6.05 -0.35 4.88e-9 Hip circumference adjusted for BMI; CESC cis rs854765 0.583 rs9912895 chr17:17826020 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.53 -6.98 -0.39 2.38e-11 Total body bone mineral density; CESC cis rs116095464 0.558 rs10057299 chr5:242135 C/T cg20965017 chr5:231967 SDHA -0.47 -5.38 -0.31 1.65e-7 Breast cancer; CESC cis rs4132509 0.739 rs10927033 chr1:243695539 C/A cg21452805 chr1:244014465 NA 0.58 6.23 0.36 1.8e-9 RR interval (heart rate); CESC cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg12386194 chr3:101231763 SENP7 0.41 5.14 0.3 5.44e-7 Colorectal cancer; CESC cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4843747 0.619 rs66508972 chr16:88086385 C/G cg17633681 chr16:88106987 BANP 0.69 8.8 0.48 1.82e-16 Menopause (age at onset); CESC cis rs561341 1.000 rs693116 chr17:30246124 C/T cg00745463 chr17:30367425 LRRC37B -0.85 -7.62 -0.42 4.38e-13 Hip circumference adjusted for BMI; CESC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg12463550 chr7:65579703 CRCP -0.57 -7.35 -0.41 2.54e-12 Aortic root size; CESC cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg10556349 chr10:835070 NA 0.47 5.2 0.3 4.05e-7 Eosinophil percentage of granulocytes; CESC cis rs2070488 0.965 rs1984312 chr3:38538466 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.89 -16.1 -0.7 3.86e-41 Electrocardiographic conduction measures; CESC cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7772486 0.817 rs2748491 chr6:146327759 T/C cg05347473 chr6:146136440 FBXO30 0.54 7.08 0.4 1.28e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg11494091 chr17:61959527 GH2 0.38 5.2 0.3 3.91e-7 Height; CESC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.49 0.42 1.01e-12 Prudent dietary pattern; CESC trans rs8057939 0.528 rs9929573 chr16:49410565 A/G cg15532236 chr6:170188124 NA 0.5 6.1 0.35 3.75e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1065852 0.526 rs8138080 chr22:42396371 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.33 -5.2 -0.3 4.09e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs9457247 0.715 rs6923582 chr6:167437162 T/A cg23791538 chr6:167370224 RNASET2 -0.54 -7.31 -0.41 3.23e-12 Crohn's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24419099 chr11:47270565 NR1H3;ACP2 -0.43 -6.23 -0.36 1.87e-9 Gambling; CESC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg13206674 chr6:150067644 NUP43 0.39 5.58 0.32 5.93e-8 Lung cancer; CESC cis rs17641971 0.684 rs6984804 chr8:49987910 G/A cg00325661 chr8:49890786 NA 0.36 5.13 0.3 5.72e-7 Blood metabolite levels; CESC cis rs9916302 0.904 rs8068427 chr17:37511517 G/A cg07936489 chr17:37558343 FBXL20 0.78 10.7 0.55 1.93e-22 Glomerular filtration rate (creatinine); CESC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg07395648 chr5:131743802 NA -0.46 -6.14 -0.35 2.92e-9 Breast cancer; CESC cis rs79976124 0.879 rs12213669 chr6:66627704 G/A cg07460842 chr6:66804631 NA 0.74 8.58 0.47 7.85e-16 Type 2 diabetes; CESC cis rs12348691 0.503 rs7847259 chr9:100600712 A/G cg13688889 chr9:100608707 NA -0.91 -13.49 -0.64 6.17e-32 Alopecia areata; CESC cis rs2576037 0.796 rs2571018 chr18:44585344 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.46 5.94 0.34 8.88e-9 Personality dimensions; CESC cis rs66530629 0.874 rs7535819 chr1:25173037 C/T cg22509179 chr1:25234806 RUNX3 0.43 5.63 0.33 4.66e-8 Plateletcrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05778415 chr2:75185968 POLE4 0.61 7.43 0.42 1.53e-12 Gut microbiome composition (summer); CESC cis rs1707322 0.964 rs785499 chr1:46592420 G/A cg06784218 chr1:46089804 CCDC17 -0.36 -5.93 -0.34 9.35e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2180341 1.000 rs4897207 chr6:127605898 C/T cg24812749 chr6:127587940 RNF146 1.06 15.35 0.69 1.74e-38 Breast cancer; CESC cis rs10752881 1.000 rs4233192 chr1:182970837 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.86 -13.93 -0.65 1.86e-33 Colorectal cancer; CESC cis rs9768139 0.935 rs7800718 chr7:158121878 G/A cg25566285 chr7:158114605 PTPRN2 -0.5 -8.54 -0.46 1.03e-15 Calcium levels; CESC cis rs9322193 0.962 rs62439843 chr6:149997657 T/C cg13206674 chr6:150067644 NUP43 0.4 5.52 0.32 8.03e-8 Lung cancer; CESC cis rs9457247 1.000 rs422780 chr6:167406209 A/G cg25258033 chr6:167368657 RNASET2 0.39 5.89 0.34 1.15e-8 Crohn's disease; CESC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg04944784 chr2:26401820 FAM59B 0.6 7.31 0.41 3.1e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20777920 chr6:10404848 TFAP2A 0.56 6.64 0.38 1.79e-10 Gut microbiome composition (summer); CESC cis rs7107174 1.000 rs2511155 chr11:77969223 G/A cg02023728 chr11:77925099 USP35 0.46 6.39 0.37 7.41e-10 Testicular germ cell tumor; CESC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg26855724 chr1:75198818 TYW3;CRYZ 0.48 6.19 0.36 2.28e-9 Resistin levels; CESC cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg10845886 chr2:3471009 TTC15 -0.67 -9.29 -0.5 5.87e-18 Neurofibrillary tangles; CESC trans rs2235573 0.551 rs139898 chr22:38399979 A/G cg19894588 chr14:64061835 NA 0.56 7.11 0.4 1.05e-11 Glioblastoma;Glioma; CESC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.46 -0.32 1.12e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14165241 chr9:131315156 SPTAN1 0.55 6.18 0.35 2.36e-9 Gut microbiome composition (summer); CESC cis rs7216064 0.953 rs62086043 chr17:65968003 A/G cg12091567 chr17:66097778 LOC651250 -0.78 -8.35 -0.46 3.75e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs796364 0.568 rs11890894 chr2:201072055 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.48 5.38 0.31 1.62e-7 Schizophrenia; CESC cis rs12900413 0.603 rs12909833 chr15:90301518 G/A cg24249390 chr15:90295951 MESP1 -0.4 -5.36 -0.31 1.79e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs950776 0.714 rs514743 chr15:78884227 A/T cg06917634 chr15:78832804 PSMA4 -0.54 -6.6 -0.38 2.19e-10 Sudden cardiac arrest; CESC cis rs4604732 0.631 rs12039642 chr1:247624898 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12477438 0.501 rs6727749 chr2:99793590 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.84 0.62 1.16e-29 Chronic sinus infection; CESC cis rs9831754 0.704 rs7647185 chr3:78468807 T/C cg06138941 chr3:78371609 NA -0.51 -6.44 -0.37 5.69e-10 Calcium levels; CESC trans rs9650657 0.562 rs10090444 chr8:10745469 C/G cg06636001 chr8:8085503 FLJ10661 0.52 6.48 0.37 4.43e-10 Neuroticism; CESC cis rs7084402 0.967 rs1649077 chr10:60293906 A/G cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.35e-18 Refractive error; CESC cis rs1059312 1.000 rs7136092 chr12:129280164 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.74 -10.51 -0.54 8.05e-22 Systemic lupus erythematosus; CESC cis rs8060686 0.516 rs73612297 chr16:68284754 T/G cg26727032 chr16:67993705 SLC12A4 -0.55 -7.23 -0.41 5.23e-12 HDL cholesterol;Metabolic syndrome; CESC cis rs8014204 0.604 rs11159109 chr14:75389074 G/A cg08847533 chr14:75593920 NEK9 0.6 7.62 0.42 4.64e-13 Caffeine consumption; CESC cis rs10851478 0.872 rs8032688 chr15:49929664 A/G cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.11 0.3 6.15e-7 Oral cavity cancer; CESC cis rs208520 0.837 rs208471 chr6:66916749 A/C cg07460842 chr6:66804631 NA -0.89 -10.85 -0.55 6.35e-23 Exhaled nitric oxide output; CESC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg06634786 chr22:41940651 POLR3H -0.68 -7.15 -0.4 8.28e-12 Vitiligo; CESC cis rs6032067 0.929 rs2664581 chr20:43804522 A/C cg10761708 chr20:43804764 PI3 0.44 5.52 0.32 7.91e-8 Blood protein levels; CESC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.24 -0.31 3.26e-7 Life satisfaction; CESC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg18357526 chr6:26021779 HIST1H4A 0.52 6.95 0.39 2.81e-11 Intelligence (multi-trait analysis); CESC cis rs4853012 0.887 rs2280644 chr2:74358411 G/A cg01017244 chr2:74357527 NA 0.68 9.44 0.5 1.95e-18 Gestational age at birth (maternal effect); CESC cis rs7666738 0.753 rs13137152 chr4:98938044 A/T cg05340658 chr4:99064831 C4orf37 0.82 12.32 0.6 6.98e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9393777 0.623 rs3757150 chr6:26476782 T/A cg12826209 chr6:26865740 GUSBL1 0.65 6.85 0.39 5.16e-11 Intelligence (multi-trait analysis); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg13823003 chr17:72856049 GRIN2C 0.46 6.59 0.38 2.3e-10 Psoriatic arthritis; CESC cis rs62064224 0.658 rs62065460 chr17:30715007 A/G cg09324608 chr17:30823087 MYO1D 0.5 7.56 0.42 6.7e-13 Schizophrenia; CESC cis rs8133932 0.521 rs1625244 chr21:47364499 C/T cg14185626 chr21:47401492 COL6A1 -0.49 -5.5 -0.32 9.03e-8 Schizophrenia; CESC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg22963979 chr7:1858916 MAD1L1 -0.38 -5.15 -0.3 5e-7 Bipolar disorder and schizophrenia; CESC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.61 -0.33 4.97e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2742417 0.603 rs2742457 chr3:45767487 G/A cg04837898 chr3:45731254 SACM1L -0.5 -6.55 -0.37 2.92e-10 Response to anti-depressant treatment in major depressive disorder; CESC cis rs6964587 0.773 rs12740 chr7:92029302 A/G cg17063962 chr7:91808500 NA 0.55 7.07 0.4 1.36e-11 Breast cancer; CESC cis rs1707322 0.964 rs10890358 chr1:46319025 T/A cg03146154 chr1:46216737 IPP 0.74 10.13 0.53 1.32e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.791 rs10013680 chr4:99023030 G/C cg05340658 chr4:99064831 C4orf37 0.75 10.97 0.56 2.55e-23 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07919162 chr19:19431259 SF4;KIAA0892 -0.67 -7.53 -0.42 7.91e-13 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg10691866 chr7:65817282 TPST1 0.31 5.37 0.31 1.75e-7 Aortic root size; CESC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg13126279 chr21:47581558 C21orf56 -0.45 -6.1 -0.35 3.79e-9 Testicular germ cell tumor; CESC cis rs6987853 0.933 rs2923434 chr8:42422307 A/G cg09913449 chr8:42400586 C8orf40 0.4 6.38 0.36 7.85e-10 Mean corpuscular hemoglobin concentration; CESC cis rs9486719 1.000 rs12197411 chr6:97039621 G/A cg06623918 chr6:96969491 KIAA0776 -0.79 -8.13 -0.45 1.64e-14 Migraine;Coronary artery disease; CESC trans rs2749592 0.550 rs7917262 chr10:37874602 A/C cg12057190 chr19:54976211 LENG9;CDC42EP5 -0.43 -6.17 -0.35 2.56e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1348850 0.837 rs12619074 chr2:178472336 G/A cg23306229 chr2:178417860 TTC30B 0.56 7.11 0.4 1.08e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11677416 1.000 rs3783520 chr2:113544339 C/T cg27083787 chr2:113543245 IL1A 0.62 7.55 0.42 6.97e-13 Response to antipsychotic treatment in schizophrenia (working memory); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08602689 chr13:103452535 BIVM;KDELC1 -0.61 -6.8 -0.39 6.8e-11 Gut microbiome composition (summer); CESC cis rs36051895 0.664 rs1034072 chr9:5088903 T/A cg02405213 chr9:5042618 JAK2 -0.54 -6.52 -0.37 3.6e-10 Pediatric autoimmune diseases; CESC cis rs9815354 0.638 rs73073258 chr3:42017894 G/A cg03022575 chr3:42003672 ULK4 0.74 6.64 0.38 1.79e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg25554036 chr4:6271136 WFS1 -0.5 -8.06 -0.44 2.62e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg06456125 chr7:65229604 NA -0.39 -5.09 -0.3 6.82e-7 Aortic root size; CESC cis rs6963495 0.818 rs73192107 chr7:105168095 G/A cg13798780 chr7:105162888 PUS7 0.77 7.88 0.44 8.3e-14 Bipolar disorder (body mass index interaction); CESC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.46 6.11 0.35 3.49e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3820068 0.705 rs16851727 chr1:15857918 C/T cg17385448 chr1:15911702 AGMAT 0.39 6.03 0.35 5.62e-9 Systolic blood pressure; CESC cis rs57221529 0.766 rs12519763 chr5:559145 C/T cg16447950 chr5:562315 NA -0.7 -7.76 -0.43 1.9e-13 Lung disease severity in cystic fibrosis; CESC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -5.6 -0.33 5.38e-8 Electroencephalogram traits; CESC cis rs910316 0.967 rs10246 chr14:75544470 T/A cg08847533 chr14:75593920 NEK9 1.0 19.06 0.76 1.34e-51 Height; CESC cis rs225245 0.610 rs321607 chr17:33880584 A/G cg05299278 chr17:33885742 SLFN14 0.38 5.2 0.3 3.9e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC trans rs3008870 0.583 rs11208985 chr1:67464666 G/A cg19754094 chr2:74055942 STAMBP -0.62 -6.0 -0.35 6.49e-9 Lymphocyte percentage of white cells; CESC cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg24675658 chr1:53192096 ZYG11B -0.6 -7.68 -0.43 3.1e-13 Monocyte count; CESC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.13 0.4 9.75e-12 Height; CESC cis rs1707322 0.686 rs1250 chr1:46094027 A/G cg06784218 chr1:46089804 CCDC17 0.41 7.26 0.41 4.37e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7659604 0.502 rs13108419 chr4:122687238 A/G cg19748678 chr4:122722346 EXOSC9 -0.45 -5.56 -0.32 6.48e-8 Type 2 diabetes; CESC cis rs7077164 0.846 rs1227773 chr10:71579347 C/A cg07630274 chr10:71583235 COL13A1 -0.41 -7.77 -0.43 1.7e-13 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs8014204 0.836 rs11159099 chr14:75235397 A/G cg08847533 chr14:75593920 NEK9 0.49 6.26 0.36 1.51e-9 Caffeine consumption; CESC cis rs1499614 1.000 rs2659911 chr7:66158420 G/A cg13147721 chr7:65941812 NA -0.94 -8.9 -0.48 9.08e-17 Gout; CESC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg00800038 chr16:89945340 TCF25 -0.69 -6.6 -0.38 2.24e-10 Skin colour saturation; CESC cis rs17376456 0.825 rs72786702 chr5:93254656 A/C cg21475434 chr5:93447410 FAM172A 0.74 6.22 0.36 1.9e-9 Diabetic retinopathy; CESC cis rs7607369 0.559 rs13002060 chr2:219660394 G/T cg02176678 chr2:219576539 TTLL4 -0.4 -7.02 -0.4 1.87e-11 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs12701220 0.690 rs10243973 chr7:1064983 T/C cg26769984 chr7:1090371 C7orf50 0.62 7.28 0.41 3.85e-12 Bronchopulmonary dysplasia; CESC cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg10556349 chr10:835070 NA 0.57 5.44 0.32 1.23e-7 Eosinophil percentage of granulocytes; CESC cis rs4699052 0.662 rs1516732 chr4:104251154 A/T cg16532752 chr4:104119610 CENPE -0.43 -6.32 -0.36 1.08e-9 Testicular germ cell tumor; CESC cis rs888194 0.544 rs7316486 chr12:109849540 A/G cg19025524 chr12:109796872 NA -0.46 -6.68 -0.38 1.4e-10 Neuroticism; CESC cis rs2742234 0.590 rs2435383 chr10:43675671 T/C cg15436174 chr10:43711423 RASGEF1A -0.5 -5.84 -0.34 1.5e-8 Hirschsprung disease; CESC cis rs832540 0.931 rs832535 chr5:56213334 C/T cg12311346 chr5:56204834 C5orf35 -0.43 -5.43 -0.32 1.25e-7 Coronary artery disease; CESC cis rs4555082 1.000 rs4334224 chr14:105759198 C/T cg06808227 chr14:105710500 BRF1 -0.52 -6.34 -0.36 9.7e-10 Mean platelet volume;Platelet distribution width; CESC trans rs208520 0.690 rs176289 chr6:66766522 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -12.45 -0.61 2.48e-28 Exhaled nitric oxide output; CESC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg17949981 chr6:28129498 ZNF389 0.41 5.38 0.31 1.66e-7 Parkinson's disease; CESC trans rs1814175 0.502 rs12365889 chr11:49623034 G/A cg03929089 chr4:120376271 NA -0.75 -8.98 -0.48 5.35e-17 Height; CESC cis rs7666738 0.830 rs11944107 chr4:98931638 G/C cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg06558623 chr16:89946397 TCF25 1.13 8.87 0.48 1.08e-16 Skin colour saturation; CESC cis rs5769765 0.773 rs7410291 chr22:50300078 A/G cg26441486 chr22:50317300 CRELD2 0.39 5.33 0.31 2.11e-7 Schizophrenia; CESC cis rs2730245 0.505 rs1188956 chr7:158690576 G/A cg01943577 chr7:158741284 NA -0.46 -6.08 -0.35 4.23e-9 Height; CESC cis rs72781680 0.848 rs2339926 chr2:24045734 C/G cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs1465370 0.720 rs1558917 chr7:130028723 C/T cg04743876 chr7:130013617 NA 0.27 5.08 0.3 7.18e-7 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs453301 0.653 rs1562211 chr8:8902424 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -6.66 -0.38 1.54e-10 Joint mobility (Beighton score); CESC cis rs2710642 0.576 rs1386399 chr2:62871303 G/A cg17519650 chr2:63277830 OTX1 0.47 5.61 0.33 5.11e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs459571 0.876 rs2520095 chr9:136919568 A/G cg13789015 chr9:136890014 NCRNA00094 0.57 8.09 0.45 2.11e-14 Platelet distribution width; CESC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.1 0.53 1.62e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08265551 chr1:151032119 CDC42SE1;MLLT11 0.57 6.89 0.39 4.14e-11 Gut microbiome composition (summer); CESC cis rs11191419 1 rs11191419 chr10:104612335 T/A cg04362960 chr10:104952993 NT5C2 0.5 6.13 0.35 3.18e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg24675658 chr1:53192096 ZYG11B 0.7 9.91 0.52 6.87e-20 Monocyte count; CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg17372223 chr3:52568218 NT5DC2 -0.47 -7.75 -0.43 1.97e-13 Electroencephalogram traits; CESC cis rs2072499 0.750 rs55910626 chr1:156159909 C/G cg24450063 chr1:156163899 SLC25A44 0.98 12.05 0.59 5.99e-27 Testicular germ cell tumor; CESC cis rs34172651 0.917 rs12930481 chr16:24775438 A/G cg06028605 chr16:24865363 SLC5A11 0.39 5.75 0.33 2.5e-8 Intelligence (multi-trait analysis); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg27127099 chr5:150158597 C5orf62 0.47 6.27 0.36 1.48e-9 Bronchopulmonary dysplasia; CESC cis rs9399135 0.967 rs2150681 chr6:135375232 A/G cg24558204 chr6:135376177 HBS1L -0.51 -6.87 -0.39 4.48e-11 Red blood cell count; CESC cis rs12893668 0.645 rs12889403 chr14:104034746 C/T cg24130564 chr14:104152367 KLC1 -0.48 -5.87 -0.34 1.31e-8 Reticulocyte count; CESC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg02951883 chr7:2050386 MAD1L1 -0.6 -7.97 -0.44 4.83e-14 Bipolar disorder and schizophrenia; CESC cis rs7772486 0.790 rs2254257 chr6:146203724 C/T cg05347473 chr6:146136440 FBXO30 0.58 7.51 0.42 9.28e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs7944735 0.671 rs1228044 chr11:48011180 A/G cg03929089 chr4:120376271 NA 0.55 6.17 0.35 2.53e-9 Intraocular pressure; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg23978390 chr7:1156363 C7orf50 0.59 8.12 0.45 1.77e-14 Longevity;Endometriosis; CESC trans rs74054849 0.850 rs55976422 chr1:16008379 T/C cg06826283 chr7:600452 PRKAR1B 0.7 6.25 0.36 1.66e-9 Alcoholic chronic pancreatitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01403123 chr2:240287795 HDAC4 -0.57 -6.69 -0.38 1.34e-10 Gut microbiome composition (summer); CESC cis rs12479064 0.724 rs62153852 chr2:99934713 C/T cg09787394 chr2:99771194 LIPT1;TSGA10 0.48 5.07 0.3 7.54e-7 Chronic sinus infection; CESC cis rs2455799 0.573 rs2470546 chr3:15733897 T/C cg09340198 chr3:15902540 ANKRD28 -0.32 -5.1 -0.3 6.53e-7 Mean platelet volume; CESC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg23161317 chr6:28129485 ZNF389 0.5 6.4 0.37 7.04e-10 Depression; CESC cis rs6537837 1.000 rs6682956 chr1:110130264 G/A cg05049280 chr1:110155535 GNAT2 0.38 5.26 0.31 3e-7 Major depressive disorder; CESC cis rs9443645 0.527 rs4706743 chr6:79615793 G/T cg05283184 chr6:79620031 NA -0.37 -5.23 -0.31 3.45e-7 Intelligence (multi-trait analysis); CESC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg25405998 chr7:65216604 CCT6P1 -0.51 -5.35 -0.31 1.94e-7 Aortic root size; CESC cis rs7084402 0.967 rs1303968 chr10:60298941 G/A cg07615347 chr10:60278583 BICC1 0.6 9.46 0.5 1.77e-18 Refractive error; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15465092 chr8:128747754 MYC -0.46 -6.51 -0.37 3.8e-10 Gut microbiota (bacterial taxa); CESC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg23758822 chr17:41437982 NA -1.0 -17.54 -0.73 3.02e-46 Menopause (age at onset); CESC cis rs1707322 1.000 rs10890365 chr1:46359348 C/T cg05343316 chr1:45956843 TESK2 0.42 5.24 0.31 3.26e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs5769765 0.862 rs9616386 chr22:50313179 G/A cg09872104 chr7:134855509 C7orf49 -0.55 -6.31 -0.36 1.19e-9 Schizophrenia; CESC cis rs10743315 0.547 rs7310796 chr12:19362390 C/T cg02471346 chr12:19282374 PLEKHA5 -0.47 -5.19 -0.3 4.11e-7 Gut microbiota (bacterial taxa); CESC cis rs8060686 0.516 rs11075670 chr16:68288393 C/G cg26727032 chr16:67993705 SLC12A4 -0.55 -7.3 -0.41 3.29e-12 HDL cholesterol;Metabolic syndrome; CESC cis rs8020095 0.528 rs1950689 chr14:67338678 C/T cg19548862 chr14:67692701 FAM71D -0.49 -5.94 -0.34 8.74e-9 Depression (quantitative trait); CESC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs8070624 0.543 rs57728924 chr17:17875342 A/G cg04398451 chr17:18023971 MYO15A -0.69 -9.51 -0.5 1.19e-18 Total body bone mineral density; CESC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg17376030 chr22:41985996 PMM1 -0.77 -8.15 -0.45 1.45e-14 Crohn's disease;Inflammatory bowel disease; CESC cis rs9302635 0.688 rs763665 chr16:72078043 C/T cg01557791 chr16:72042693 DHODH -0.62 -5.11 -0.3 6.11e-7 Blood protein levels; CESC cis rs11150038 0.826 rs9926583 chr16:78087730 C/T cg04733911 chr16:78082701 NA -0.43 -5.34 -0.31 2.02e-7 Colorectal or endometrial cancer; CESC cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg05347473 chr6:146136440 FBXO30 0.59 7.59 0.42 5.36e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.52 0.61 1.45e-28 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg12463550 chr7:65579703 CRCP -0.55 -7.02 -0.4 1.82e-11 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20818191 chr4:866154 GAK -0.61 -6.75 -0.38 9.36e-11 Gut microbiome composition (summer); CESC cis rs6570726 0.818 rs398812 chr6:145817271 T/C cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs116988415 0.584 rs17767466 chr14:65252095 G/T cg25083366 chr14:65239357 SPTB 0.7 5.29 0.31 2.6e-7 Daytime sleep phenotypes; CESC cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg11663144 chr21:46675770 NA -0.45 -6.02 -0.35 5.74e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19419993 chr17:65374049 PITPNC1 -0.5 -7.2 -0.4 6.22e-12 Gut microbiota (bacterial taxa); CESC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg27170947 chr2:26402098 FAM59B 0.53 6.74 0.38 9.89e-11 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.75 0.33 2.41e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9443189 0.570 rs7770824 chr6:76408189 G/A cg01950844 chr6:76311363 SENP6 0.88 9.29 0.5 6.05e-18 Prostate cancer; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg04700215 chr12:46320110 SFRS2IP 0.38 6.16 0.35 2.7e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9323205 0.577 rs9672038 chr14:51724856 A/G cg23942311 chr14:51606299 NA -0.44 -6.5 -0.37 4.01e-10 Cancer; CESC cis rs9902453 0.845 rs12602426 chr17:28158815 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.38 0.46 3.08e-15 Coffee consumption (cups per day); CESC cis rs11971779 0.941 rs74299967 chr7:139043769 G/T cg07862535 chr7:139043722 LUC7L2 0.56 5.74 0.33 2.55e-8 Diisocyanate-induced asthma; CESC cis rs7208859 0.623 rs9916727 chr17:29107472 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4374383 1.000 rs4374383 chr2:112770770 A/G cg07905836 chr2:113190072 RGPD8;RGPD5 -0.45 -5.17 -0.3 4.66e-7 Hepatitis C induced liver fibrosis; CESC cis rs6088590 1.000 rs11698977 chr20:33449691 C/T cg24642439 chr20:33292090 TP53INP2 0.85 11.94 0.59 1.39e-26 Coronary artery disease; CESC cis rs4697263 0.580 rs7657801 chr4:22044236 C/T cg16694489 chr4:22509445 GPR125 0.4 5.55 0.32 6.77e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs651907 0.535 rs13065944 chr3:101473088 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.88 0.34 1.22e-8 Colorectal cancer; CESC trans rs694739 0.628 rs11606081 chr11:64137875 T/C cg01888411 chr11:34378293 ABTB2 0.4 6.01 0.35 6e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs2249625 0.564 rs2463734 chr6:72882558 C/T cg18830697 chr6:72922368 RIMS1 -0.46 -6.81 -0.39 6.53e-11 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs854765 0.583 rs950966 chr17:17783748 A/G cg16928487 chr17:17741425 SREBF1 0.6 10.48 0.54 9.88e-22 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08949011 chr10:99400449 PI4K2A 0.69 7.66 0.43 3.49e-13 Gut microbiome composition (summer); CESC cis rs2635047 0.811 rs17785419 chr18:44765469 A/G cg19077165 chr18:44547161 KATNAL2 0.38 5.12 0.3 5.77e-7 Educational attainment; CESC cis rs8020095 0.571 rs8012063 chr14:67434470 G/A cg19548862 chr14:67692701 FAM71D -0.49 -5.89 -0.34 1.15e-8 Depression (quantitative trait); CESC cis rs2235544 0.664 rs12036530 chr1:54476323 T/C cg25741118 chr1:54482237 LDLRAD1 -0.24 -6.21 -0.36 2.01e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs9303401 0.659 rs62083368 chr17:56878062 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.5 0.61 1.71e-28 Cognitive test performance; CESC trans rs10435719 0.899 rs7815595 chr8:11792351 C/A cg15556689 chr8:8085844 FLJ10661 0.52 6.39 0.37 7.33e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs4950322 0.570 rs72691098 chr1:146771840 G/A cg22381352 chr1:146742008 CHD1L -0.46 -5.05 -0.3 8.32e-7 Protein quantitative trait loci; CESC cis rs7847628 0.587 rs10760117 chr9:123586737 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.94 17.46 0.73 5.92e-46 Birth weight; CESC cis rs11122272 0.766 rs2790867 chr1:231548059 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.58 7.93 0.44 5.95e-14 Hemoglobin concentration; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg21146272 chr6:42858716 C6orf226 -0.46 -6.15 -0.35 2.83e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11608355 0.545 rs4766473 chr12:109900596 C/T cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.98 0.39 2.38e-11 Bipolar disorder; CESC cis rs559928 0.549 rs57831436 chr11:64007297 C/T cg18225595 chr11:63971243 STIP1 0.66 5.46 0.32 1.08e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs6582630 0.519 rs4405392 chr12:38293661 A/C cg13010199 chr12:38710504 ALG10B 0.46 5.88 0.34 1.26e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs12134245 0.755 rs11164928 chr1:92012678 G/A cg07090678 chr1:91966139 CDC7 0.37 5.3 0.31 2.39e-7 Breast cancer; CESC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg08859206 chr1:53392774 SCP2 0.71 11.13 0.56 7.51e-24 Monocyte count; CESC cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg08564027 chr20:61660810 NA 0.9 15.36 0.69 1.69e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg18765753 chr7:1198926 ZFAND2A -0.38 -5.44 -0.32 1.23e-7 Longevity;Endometriosis; CESC cis rs80130819 0.636 rs4760623 chr12:48619256 A/C cg05342945 chr12:48394962 COL2A1 -0.48 -5.2 -0.3 4.07e-7 Prostate cancer; CESC cis rs72627123 0.500 rs7359018 chr14:74521008 T/C cg05179529 chr14:74551516 LIN52;ALDH6A1 0.53 5.94 0.34 9.08e-9 Morning vs. evening chronotype; CESC cis rs7772486 0.790 rs2247666 chr6:146220409 C/A cg05347473 chr6:146136440 FBXO30 0.57 7.31 0.41 3.07e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6540556 0.654 rs6540549 chr1:209922668 G/T cg05527609 chr1:210001259 C1orf107 0.41 5.08 0.3 7.27e-7 Red blood cell count; CESC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.6 -0.42 4.99e-13 Gut microbiome composition (summer); CESC cis rs7264396 0.676 rs6060729 chr20:34557004 G/C cg17201900 chr20:34330562 RBM39 0.51 5.31 0.31 2.37e-7 Total cholesterol levels; CESC cis rs4835473 0.932 rs12512652 chr4:144657940 A/T cg25736465 chr4:144833511 NA -0.33 -5.05 -0.3 8.38e-7 Immature fraction of reticulocytes; CESC cis rs12711979 0.509 rs10178286 chr2:3823821 A/G cg17052675 chr2:3827356 NA 0.66 10.56 0.54 5.58e-22 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs7659604 0.628 rs6838153 chr4:122720999 A/G cg06713675 chr4:122721982 EXOSC9 -0.51 -7.04 -0.4 1.65e-11 Type 2 diabetes; CESC cis rs10755723 1 rs10755723 chr6:42593718 T/A cg10605015 chr6:42532144 UBR2 0.52 5.89 0.34 1.18e-8 Lung cancer in never smokers; CESC cis rs2651899 0.867 rs207200 chr1:3073555 T/C cg22674798 chr1:3096360 PRDM16 0.41 8.06 0.44 2.65e-14 Migraine; CESC cis rs2228479 0.867 rs62056110 chr16:89946388 A/C cg04013166 chr16:89971882 TCF25 0.77 7.14 0.4 8.86e-12 Skin colour saturation; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14405528 chr22:47372700 TBC1D22A -0.52 -6.81 -0.39 6.57e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1707322 0.717 rs28396194 chr1:46213227 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7927592 0.731 rs2840367 chr11:68302101 G/A cg20283391 chr11:68216788 NA 0.43 5.45 0.32 1.16e-7 Total body bone mineral density; CESC cis rs965513 1.000 rs10983761 chr9:100553957 A/C cg13688889 chr9:100608707 NA -0.58 -8.26 -0.45 6.88e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs7551222 0.634 rs12139477 chr1:204553104 A/C cg20240347 chr1:204465584 NA -0.3 -6.02 -0.35 5.95e-9 Schizophrenia; CESC cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg11752832 chr7:134001865 SLC35B4 0.51 6.52 0.37 3.54e-10 Mean platelet volume; CESC trans rs718857 0.524 rs1443841 chr9:106721632 A/G cg24317979 chr2:87302855 LOC285074 0.48 6.0 0.35 6.37e-9 Breast cancer; CESC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.72 0.62 2.99e-29 Alzheimer's disease; CESC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs4737010 0.501 rs1579274 chr8:41658923 T/G cg08923054 chr8:41654455 ANK1 0.59 7.24 0.41 4.99e-12 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs28489187 0.683 rs233050 chr1:85837793 T/C cg16011679 chr1:85725395 C1orf52 0.54 6.3 0.36 1.25e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg00271154 chr2:113033418 ZC3H6 -0.43 -6.78 -0.38 7.97e-11 Vertical cup-disc ratio; CESC cis rs9291683 0.527 rs73212848 chr4:10093299 T/C cg05927159 chr4:10118984 WDR1 0.34 5.05 0.3 8.15e-7 Bone mineral density; CESC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg24768116 chr2:27665128 KRTCAP3 -0.31 -5.63 -0.33 4.62e-8 Total body bone mineral density; CESC cis rs7824557 0.564 rs1435275 chr8:11235735 T/C cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.52e-14 Retinal vascular caliber; CESC cis rs1707322 0.721 rs12043945 chr1:46106922 T/A cg06784218 chr1:46089804 CCDC17 0.42 7.35 0.41 2.41e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs854765 0.647 rs2056842 chr17:18009028 C/T cg09796270 chr17:17721594 SREBF1 0.42 5.56 0.32 6.44e-8 Total body bone mineral density; CESC cis rs9462846 0.841 rs66541797 chr6:42825942 C/T cg05552183 chr6:42928497 GNMT 0.44 5.28 0.31 2.69e-7 Blood protein levels; CESC trans rs877282 0.898 rs12357995 chr10:765739 T/C cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs847577 0.588 rs12666406 chr7:97790991 G/A cg21770322 chr7:97807741 LMTK2 0.83 13.92 0.65 1.95e-33 Breast cancer; CESC cis rs80130819 0.892 rs7966139 chr12:48628757 T/A cg05342945 chr12:48394962 COL2A1 -0.68 -5.38 -0.31 1.64e-7 Prostate cancer; CESC cis rs7680126 0.596 rs17418533 chr4:10316941 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -5.18 -0.3 4.42e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs17376456 0.877 rs12374463 chr5:93483569 C/G cg21475434 chr5:93447410 FAM172A 0.88 7.64 0.42 3.98e-13 Diabetic retinopathy; CESC cis rs9300255 0.507 rs1727302 chr12:123632930 G/A cg00376283 chr12:123451042 ABCB9 0.68 9.08 0.49 2.6e-17 Neutrophil percentage of white cells; CESC cis rs8114671 0.562 rs4911447 chr20:33479445 T/A cg06115741 chr20:33292138 TP53INP2 0.47 5.66 0.33 4e-8 Height; CESC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg02034447 chr16:89574710 SPG7 0.53 6.83 0.39 5.85e-11 Multiple myeloma (IgH translocation); CESC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs7332672 0.532 rs9284183 chr13:99946371 G/A cg21788972 chr13:99853209 UBAC2 -0.4 -5.13 -0.3 5.56e-7 Eosinophil counts; CESC trans rs10054504 0.722 rs57193891 chr5:32001061 C/T cg16516980 chr11:1535048 HCCA2 -0.76 -6.42 -0.37 6.4e-10 Renal cell carcinoma; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg03404566 chr17:6899310 ALOX12 0.37 6.18 0.35 2.47e-9 Tonsillectomy; CESC cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg22467129 chr15:76604101 ETFA -0.38 -5.68 -0.33 3.56e-8 Blood metabolite levels; CESC cis rs16867321 0.588 rs2368175 chr2:181493763 G/C cg23363182 chr2:181467187 NA -0.52 -7.96 -0.44 5.11e-14 Obesity; CESC cis rs6570726 0.791 rs379040 chr6:145889035 T/C cg23711669 chr6:146136114 FBXO30 0.91 13.76 0.65 7.31e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs9470366 0.883 rs7756236 chr6:36627053 A/G cg08179530 chr6:36648295 CDKN1A 0.51 6.24 0.36 1.76e-9 QRS duration; CESC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg07507251 chr3:52567010 NT5DC2 -0.41 -7.05 -0.4 1.55e-11 Bipolar disorder; CESC cis rs1801251 1.000 rs1801251 chr2:233633460 G/A cg08000102 chr2:233561755 GIGYF2 0.67 9.48 0.5 1.53e-18 Coronary artery disease; CESC trans rs10776614 0.799 rs1473323 chr10:49764820 A/G cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.72 9.23 0.49 8.74e-18 Multiple sclerosis; CESC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg27170947 chr2:26402098 FAM59B 0.87 9.82 0.52 1.27e-19 Gut microbiome composition (summer); CESC cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg25019033 chr10:957182 NA -0.53 -5.67 -0.33 3.77e-8 Eosinophil percentage of granulocytes; CESC cis rs244293 0.665 rs6504947 chr17:53004144 T/A cg19360675 chr17:53046073 COX11;STXBP4 -0.42 -5.33 -0.31 2.12e-7 Menarche (age at onset); CESC cis rs7666738 0.830 rs10014284 chr4:98681951 G/C cg05340658 chr4:99064831 C4orf37 0.76 10.99 0.56 2.11e-23 Colonoscopy-negative controls vs population controls; CESC cis rs2046867 0.818 rs62249863 chr3:72868666 G/C cg25664220 chr3:72788482 NA -0.45 -6.52 -0.37 3.55e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs2273669 0.588 rs75995854 chr6:109325624 C/A cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs7927771 0.524 rs4752796 chr11:47841862 A/G cg18512352 chr11:47633146 NA -0.36 -5.55 -0.32 6.84e-8 Subjective well-being; CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg18402987 chr7:1209562 NA 0.46 6.1 0.35 3.76e-9 Longevity;Endometriosis; CESC trans rs7246760 0.737 rs73501268 chr19:9803081 G/A cg02900749 chr2:68251473 NA -0.82 -7.19 -0.4 6.67e-12 Pursuit maintenance gain; CESC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg21144161 chr5:423903 AHRR 0.38 6.08 0.35 4.1e-9 Cystic fibrosis severity; CESC trans rs2764766 0.721 rs245180 chr5:127204314 G/A cg15764593 chr10:829463 NA -0.4 -6.29 -0.36 1.33e-9 Schizophrenia; CESC trans rs987724 0.542 rs4680304 chr3:156531273 G/A cg04543008 chr11:71955332 PHOX2A 0.36 6.0 0.35 6.61e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CESC cis rs78456975 1.000 rs6708604 chr2:1556887 C/T cg01028140 chr2:1542097 TPO -0.58 -5.93 -0.34 9.51e-9 Placebo response in major depressive disorder (% change in symptom score); CESC trans rs58106596 0.660 rs62197212 chr2:232562727 G/A cg01370599 chr3:116745421 NA 0.5 6.14 0.35 3.02e-9 White blood cell count;Lymphocyte counts; CESC trans rs2207136 0.835 rs532847 chr6:50910439 T/C cg06522515 chr3:184090630 THPO -0.36 -6.19 -0.36 2.26e-9 Myopia; CESC cis rs734999 0.549 rs6670198 chr1:2520527 T/C cg20673091 chr1:2541236 MMEL1 0.43 7.14 0.4 9.15e-12 Ulcerative colitis; CESC cis rs910316 0.763 rs175490 chr14:75545685 A/G cg11812906 chr14:75593930 NEK9 0.83 13.63 0.64 2.12e-32 Height; CESC cis rs12479064 0.724 rs6748200 chr2:100080895 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.56 -6.69 -0.38 1.34e-10 Chronic sinus infection; CESC cis rs561341 1.000 rs7216102 chr17:30259450 A/G cg19193384 chr17:30244184 NA -0.47 -5.6 -0.33 5.4e-8 Hip circumference adjusted for BMI; CESC cis rs933688 1.000 rs12651840 chr5:90729592 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.13 14.43 0.66 3.18e-35 Smoking behavior; CESC trans rs7943203 0.962 rs611646 chr11:108177097 T/A cg24155668 chr6:36098398 MAPK13 -0.49 -6.14 -0.35 3.01e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg16405210 chr4:1374714 KIAA1530 0.47 6.04 0.35 5.3e-9 Obesity-related traits; CESC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.19 0.53 8.59e-21 Prudent dietary pattern; CESC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg18230493 chr5:56204884 C5orf35 -0.71 -8.42 -0.46 2.36e-15 Initial pursuit acceleration; CESC cis rs12586317 0.620 rs10145433 chr14:35583333 G/A cg16230307 chr14:35515116 FAM177A1 0.92 10.08 0.53 1.98e-20 Psoriasis; CESC cis rs7107174 0.892 rs11601866 chr11:78011153 G/A cg02023728 chr11:77925099 USP35 0.51 6.71 0.38 1.14e-10 Testicular germ cell tumor; CESC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg12419862 chr22:24373484 LOC391322 -0.69 -9.86 -0.52 9.48e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs9929218 0.954 rs17715799 chr16:68830511 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.64 -8.24 -0.45 7.98e-15 Colorectal cancer; CESC cis rs11864453 0.826 rs2240243 chr16:72137561 A/G cg01557791 chr16:72042693 DHODH 0.51 6.66 0.38 1.57e-10 Fibrinogen levels; CESC cis rs12142240 0.698 rs6690075 chr1:46819848 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC trans rs877282 0.945 rs11253391 chr10:788752 G/A cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs1215050 0.791 rs1215055 chr4:98865454 C/T cg05340658 chr4:99064831 C4orf37 -0.5 -6.61 -0.38 2.14e-10 Waist-to-hip ratio adjusted for body mass index; CESC trans rs7944735 0.671 rs1228044 chr11:48011180 A/G cg15704280 chr7:45808275 SEPT13 0.65 7.61 0.42 4.93e-13 Intraocular pressure; CESC cis rs4700695 0.719 rs36922 chr5:65464856 C/T cg21114390 chr5:65439923 SFRS12 -0.48 -5.85 -0.34 1.46e-8 Facial morphology (factor 19); CESC cis rs8072100 0.817 rs11869940 chr17:45578435 T/A cg08085267 chr17:45401833 C17orf57 0.44 5.77 0.33 2.18e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs3011225 0.683 rs4660753 chr1:44321044 G/A cg13606994 chr1:44402422 ARTN -0.35 -5.14 -0.3 5.31e-7 Amyotrophic lateral sclerosis (age of onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06662685 chr11:2907073 CDKN1C -0.45 -6.14 -0.35 3.06e-9 Gut microbiota (bacterial taxa); CESC cis rs672059 0.934 rs641057 chr1:183156859 A/G ch.1.3577855R chr1:183094577 LAMC1 0.54 6.99 0.39 2.28e-11 Hypertriglyceridemia; CESC cis rs10751667 0.666 rs7396473 chr11:966181 T/C cg06064525 chr11:970664 AP2A2 -0.48 -9.29 -0.5 5.99e-18 Alzheimer's disease (late onset); CESC cis rs4835473 0.897 rs7687156 chr4:144630115 T/C cg25736465 chr4:144833511 NA 0.4 6.17 0.35 2.59e-9 Immature fraction of reticulocytes; CESC cis rs4423214 0.610 rs12793607 chr11:71129316 C/T cg05163923 chr11:71159392 DHCR7 -0.59 -8.0 -0.44 3.86e-14 Vitamin D levels; CESC cis rs752010 0.806 rs1109255 chr1:42091708 C/T cg06885757 chr1:42089581 HIVEP3 0.5 8.31 0.45 5.03e-15 Lupus nephritis in systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19742965 chr7:42006083 GLI3 0.47 6.12 0.35 3.42e-9 Fibrinogen levels; CESC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg24642844 chr7:1081250 C7orf50 -0.62 -8.19 -0.45 1.15e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg25019033 chr10:957182 NA -0.6 -6.51 -0.37 3.72e-10 Eosinophil percentage of granulocytes; CESC cis rs763014 0.931 rs3752568 chr16:628302 A/G cg00908189 chr16:619842 PIGQ 0.67 9.39 0.5 2.81e-18 Height; CESC trans rs7944735 0.832 rs7130876 chr11:48050995 A/G cg15704280 chr7:45808275 SEPT13 0.64 6.53 0.37 3.26e-10 Intraocular pressure; CESC cis rs7107174 1.000 rs2292572 chr11:78052864 G/T cg02023728 chr11:77925099 USP35 0.38 5.39 0.31 1.57e-7 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17260383 chr8:22298246 PPP3CC 0.64 6.94 0.39 3.08e-11 Gut microbiome composition (summer); CESC cis rs7116495 0.609 rs1894004 chr11:71759817 G/A cg26138937 chr11:71823887 C11orf51 -1.33 -8.44 -0.46 2.03e-15 Severe influenza A (H1N1) infection; CESC cis rs11723261 0.664 rs4627799 chr4:132389 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.48 5.81 0.34 1.78e-8 Immune response to smallpox vaccine (IL-6); CESC cis rs6087990 0.836 rs2424909 chr20:31361861 T/C cg13636640 chr20:31349939 DNMT3B 0.91 16.01 0.7 8.02e-41 Ulcerative colitis; CESC cis rs10256972 0.528 rs7784607 chr7:1178694 A/G cg22907277 chr7:1156413 C7orf50 0.42 6.05 0.35 4.95e-9 Longevity;Endometriosis; CESC cis rs2718058 0.501 rs2717938 chr7:37702545 C/T cg15028436 chr7:37888078 TXNDC3 -0.36 -5.73 -0.33 2.69e-8 Alzheimer's disease (late onset); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg13959152 chr12:100535986 UHRF1BP1L -0.45 -6.08 -0.35 4.11e-9 Height; CESC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg05552183 chr6:42928497 GNMT -0.59 -9.09 -0.49 2.38e-17 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2012796 0.743 rs12435764 chr14:81836866 A/C cg02996355 chr14:81879375 NA 0.65 8.05 0.44 2.88e-14 Night sleep phenotypes; CESC cis rs9399135 0.967 rs9402676 chr6:135355507 C/T cg24558204 chr6:135376177 HBS1L 0.52 7.14 0.4 9.16e-12 Red blood cell count; CESC cis rs7264396 0.790 rs12480622 chr20:34234620 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -10.48 -0.54 1.01e-21 Total cholesterol levels; CESC cis rs790123 1.000 rs790125 chr3:122388464 A/G cg17380795 chr3:122379686 NA 0.38 5.65 0.33 4.19e-8 Response to angiotensin II receptor blocker therapy; CESC cis rs8062405 0.824 rs4788083 chr16:28545449 A/G cg07382826 chr16:28625726 SULT1A1 0.3 5.03 0.3 8.87e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs11764590 0.694 rs10276536 chr7:2086960 C/T cg21782813 chr7:2030301 MAD1L1 -0.4 -5.34 -0.31 2.04e-7 Neuroticism; CESC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg13906792 chr15:75199810 C15orf17 -0.34 -5.03 -0.3 9.02e-7 Breast cancer; CESC cis rs9486719 1.000 rs6921291 chr6:97066242 C/T cg18709589 chr6:96969512 KIAA0776 -0.55 -6.01 -0.35 6.27e-9 Migraine;Coronary artery disease; CESC cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.95e-9 Extrinsic epigenetic age acceleration; CESC cis rs911555 0.723 rs11160751 chr14:103925740 T/C cg24130564 chr14:104152367 KLC1 -0.52 -6.88 -0.39 4.27e-11 Intelligence (multi-trait analysis); CESC cis rs6088590 0.965 rs6119534 chr20:33441257 C/T cg06115741 chr20:33292138 TP53INP2 0.6 7.48 0.42 1.06e-12 Coronary artery disease; CESC cis rs2354432 0.607 rs6694347 chr1:146751140 T/C cg25205988 chr1:146714368 CHD1L -0.9 -7.78 -0.43 1.64e-13 Mitochondrial DNA levels; CESC cis rs909674 0.662 rs2899318 chr22:39837625 A/G cg24399712 chr22:39784796 NA -0.82 -10.89 -0.56 4.46e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7267979 1.000 rs2482931 chr20:25334445 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -15.92 -0.7 1.72e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg10645314 chr2:3704589 ALLC -0.62 -6.02 -0.35 5.68e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs589448 0.933 rs523398 chr12:69752775 C/T cg22834771 chr12:69754056 YEATS4 -0.54 -7.24 -0.41 4.92e-12 Cerebrospinal fluid biomarker levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04822973 chr14:68086311 ARG2 0.57 6.31 0.36 1.15e-9 Gut microbiome composition (summer); CESC cis rs1670533 1.000 rs11725984 chr4:1087338 C/T cg27284194 chr4:1044797 NA 0.48 6.17 0.35 2.6e-9 Recombination rate (females); CESC cis rs12348691 0.503 rs907576 chr9:100615359 C/T cg13688889 chr9:100608707 NA -0.9 -13.65 -0.64 1.78e-32 Alopecia areata; CESC trans rs304172 0.793 rs478412 chr3:62779627 G/A cg14089474 chr19:45280184 CBLC 0.55 6.21 0.36 2.06e-9 IgG glycosylation; CESC cis rs2933343 0.729 rs1680781 chr3:128612830 C/A cg11901034 chr3:128598214 ACAD9 -0.36 -5.17 -0.3 4.68e-7 IgG glycosylation; CESC cis rs8112211 0.953 rs61160177 chr19:38819463 C/G cg14299480 chr19:38876666 GGN -0.43 -5.81 -0.34 1.82e-8 Blood protein levels; CESC cis rs6543140 0.964 rs10193485 chr2:103089573 T/C cg04239558 chr2:103089729 SLC9A4 0.48 6.27 0.36 1.49e-9 Blood protein levels; CESC cis rs10493773 0.609 rs12058974 chr1:86192235 T/A cg17807903 chr1:86174739 ZNHIT6 -0.44 -6.53 -0.37 3.43e-10 Urate levels in overweight individuals; CESC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Depression; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22806557 chr3:178865281 PIK3CA 0.55 7.53 0.42 7.92e-13 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7824557 0.564 rs11782430 chr8:11226071 A/G cg27411982 chr8:10470053 RP1L1 -0.45 -5.59 -0.32 5.79e-8 Retinal vascular caliber; CESC cis rs4604732 0.631 rs10925044 chr1:247627071 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.15 0.4 8.36e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01594514 chr11:67374213 NDUFV1 0.61 6.85 0.39 5.16e-11 Gut microbiome composition (summer); CESC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs2637266 0.703 rs846637 chr10:78534627 G/A cg18941641 chr10:78392320 NA 0.4 7.71 0.43 2.61e-13 Pulmonary function; CESC cis rs11871801 1.000 rs12937756 chr17:40576813 C/A cg21433558 chr17:40837037 CNTNAP1 0.45 5.04 0.3 8.46e-7 Crohn's disease; CESC cis rs2370759 1.000 rs11594459 chr10:32561858 A/C cg18270830 chr10:32634957 EPC1 0.72 6.74 0.38 1.01e-10 Sexual dysfunction (female); CESC cis rs10206020 0.921 rs10177509 chr2:1568536 T/C cg12573674 chr2:1569213 NA -0.45 -5.18 -0.3 4.31e-7 IgG glycosylation; CESC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg18404041 chr3:52824283 ITIH1 0.35 6.09 0.35 3.85e-9 Electroencephalogram traits; CESC cis rs1552244 0.554 rs3732965 chr3:10048760 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -7.17 -0.4 7.49e-12 Alzheimer's disease; CESC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg00255919 chr5:131827918 IRF1 -0.35 -5.05 -0.3 8.15e-7 Breast cancer;Mosquito bite size; CESC cis rs10870270 0.956 rs6557 chr10:133781449 C/T cg17892150 chr10:133769511 PPP2R2D -0.86 -12.54 -0.61 1.24e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2415984 0.562 rs34386313 chr14:46908479 C/T cg14871534 chr14:47121158 RPL10L 0.43 6.0 0.35 6.49e-9 Number of children ever born; CESC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg06873352 chr17:61820015 STRADA 0.73 13.0 0.62 3.22e-30 Prudent dietary pattern; CESC cis rs3820928 0.874 rs13423714 chr2:227896652 C/G cg11843606 chr2:227700838 RHBDD1 0.46 6.01 0.35 6.23e-9 Pulmonary function; CESC cis rs2742234 0.518 rs1254967 chr10:43690391 G/A cg07801480 chr10:43725741 RASGEF1A -0.41 -5.3 -0.31 2.46e-7 Hirschsprung disease; CESC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg18252515 chr7:66147081 NA -0.43 -5.62 -0.33 4.9e-8 Aortic root size; CESC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg22549504 chr19:17448937 GTPBP3 0.52 5.88 0.34 1.24e-8 Systemic lupus erythematosus; CESC cis rs4563143 0.502 rs73029061 chr19:29283980 T/A cg04546413 chr19:29218101 NA 0.52 6.75 0.38 9.46e-11 Methadone dose in opioid dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05947391 chr16:2918414 NA 0.61 6.52 0.37 3.56e-10 Gut microbiome composition (summer); CESC cis rs6964587 1.000 rs6969536 chr7:91689351 C/G cg17063962 chr7:91808500 NA 0.59 8.09 0.45 2.1e-14 Breast cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08135815 chr12:94533765 NA 0.4 6.13 0.35 3.21e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10129255 0.701 rs2005643 chr14:107132304 C/T cg07958169 chr14:107095056 NA -0.43 -6.37 -0.36 8.53e-10 Kawasaki disease; CESC cis rs7107174 1.000 rs12277648 chr11:78054336 C/T cg02023728 chr11:77925099 USP35 0.39 5.55 0.32 7.03e-8 Testicular germ cell tumor; CESC cis rs897080 0.552 rs1067374 chr2:44650250 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.5 -6.06 -0.35 4.57e-9 Height; CESC cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg00074818 chr8:8560427 CLDN23 0.38 5.41 0.32 1.39e-7 Obesity-related traits; CESC cis rs6032067 1.000 rs6032065 chr20:43855649 C/T cg10761708 chr20:43804764 PI3 0.52 6.29 0.36 1.34e-9 Blood protein levels; CESC trans rs208520 0.690 rs6929762 chr6:66709277 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.41 0.61 3.59e-28 Exhaled nitric oxide output; CESC cis rs138880 0.542 rs9616215 chr22:50318834 C/T cg02269571 chr22:50332266 NA -0.65 -6.15 -0.35 2.82e-9 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11004508 chr12:74686423 NA 0.47 6.57 0.37 2.6200000000000003e-10 Fibrinogen levels; CESC cis rs637571 0.522 rs556643 chr11:65733289 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.39 5.13 0.3 5.53e-7 Eosinophil percentage of white cells; CESC cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg02079420 chr8:82753780 SNX16 0.56 7.65 0.43 3.64e-13 Diastolic blood pressure; CESC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg06108461 chr20:60628389 TAF4 -0.91 -13.97 -0.65 1.32e-33 Body mass index; CESC cis rs10465746 0.935 rs11807807 chr1:84424071 C/T cg10977910 chr1:84465055 TTLL7 0.47 6.26 0.36 1.58e-9 Obesity-related traits; CESC cis rs6460942 0.915 rs75158182 chr7:12456059 C/T cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC cis rs854765 0.547 rs4459604 chr17:17888549 A/G cg16928487 chr17:17741425 SREBF1 -0.6 -10.06 -0.53 2.31e-20 Total body bone mineral density; CESC cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9300255 0.663 rs7953929 chr12:123758235 C/G cg19016782 chr12:123741754 C12orf65 -0.41 -5.18 -0.3 4.29e-7 Neutrophil percentage of white cells; CESC cis rs3845702 0.736 rs3845701 chr2:180826781 A/G cg01881094 chr2:180872142 CWC22 -0.98 -9.07 -0.49 2.78e-17 Schizophrenia; CESC cis rs6460942 1.000 rs77494477 chr7:12315302 A/T cg10578991 chr7:12443926 VWDE -0.61 -6.41 -0.37 6.66e-10 Coronary artery disease; CESC cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg07636037 chr3:49044803 WDR6 1.01 18.68 0.75 2.81e-50 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05112967 chr7:63353492 NA -0.66 -8.12 -0.45 1.8e-14 Gut microbiome composition (summer); CESC cis rs3008870 0.709 rs62883160 chr1:67392889 G/A cg02640540 chr1:67518911 SLC35D1 0.45 5.41 0.32 1.39e-7 Lymphocyte percentage of white cells; CESC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg17971929 chr21:40555470 PSMG1 -0.6 -8.01 -0.44 3.65e-14 Menarche (age at onset); CESC cis rs7909074 1.000 rs4948927 chr10:45397071 G/A cg05187965 chr10:45406764 TMEM72 -0.33 -5.1 -0.3 6.34e-7 Mean corpuscular volume; CESC cis rs10883723 0.703 rs7898410 chr10:104245858 T/C cg22532475 chr10:104410764 TRIM8 -0.33 -5.63 -0.33 4.68e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs1707322 0.963 rs6429581 chr1:46319096 G/A cg06784218 chr1:46089804 CCDC17 0.35 5.87 0.34 1.33e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7902708 0.920 rs7898709 chr10:54423398 T/G cg26219051 chr22:43739629 SCUBE1 -0.48 -6.08 -0.35 4.13e-9 Bone properties (heel); CESC cis rs10089 1.000 rs59484271 chr5:127503781 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 9.09 0.49 2.47e-17 Ileal carcinoids; CESC cis rs634534 0.622 rs593525 chr11:65727799 T/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.75 0.38 9.36e-11 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs916888 0.773 rs199457 chr17:44795469 C/T cg17911788 chr17:44343683 NA -0.63 -8.15 -0.45 1.45e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs61931739 0.534 rs11053075 chr12:34207009 A/G cg19457237 chr12:34500585 NA 0.39 5.47 0.32 1.06e-7 Morning vs. evening chronotype; CESC cis rs9814567 1.000 rs9827987 chr3:134272621 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.37 -0.36 8.41e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs3820928 0.934 rs1366756 chr2:227772038 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.74 -0.33 2.55e-8 Pulmonary function; CESC cis rs897080 0.515 rs1067332 chr2:44626972 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.82 0.34 1.67e-8 Height; CESC cis rs12142240 0.698 rs966907 chr1:46817125 C/G cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs4950928 0.823 rs4950882 chr1:203164848 A/G cg14085262 chr1:203155938 CHI3L1 -0.53 -5.76 -0.33 2.36e-8 YKL-40 levels; CESC cis rs57221529 0.655 rs11948381 chr5:568413 A/T cg09021430 chr5:549028 NA -0.47 -6.43 -0.37 6.07e-10 Lung disease severity in cystic fibrosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02005709 chr14:92492924 TRIP11 -0.55 -6.92 -0.39 3.36e-11 Gut microbiome composition (summer); CESC cis rs2243480 0.522 rs431168 chr7:65511604 G/T cg18252515 chr7:66147081 NA -1.25 -9.3 -0.5 5.42e-18 Diabetic kidney disease; CESC cis rs12136530 0.593 rs4911990 chr1:19731873 A/C cg01832549 chr1:19774989 CAPZB -0.4 -5.82 -0.34 1.67e-8 Lead levels in blood; CESC cis rs902774 0.554 rs4503623 chr12:53353759 T/C cg14581129 chr12:53358946 NA -0.46 -6.14 -0.35 2.99e-9 Prostate cancer; CESC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg03467027 chr4:99064603 C4orf37 0.43 5.35 0.31 1.91e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.62 0.33 4.81e-8 Bipolar disorder; CESC cis rs4478858 0.698 rs10914370 chr1:31854955 T/C cg00250761 chr1:31883323 NA -0.26 -5.04 -0.3 8.56e-7 Alcohol dependence; CESC cis rs595982 0.527 rs17272673 chr19:49362992 C/A cg15549821 chr19:49342101 PLEKHA4 -0.69 -7.74 -0.43 2.11e-13 Red cell distribution width; CESC cis rs11792861 0.816 rs17792434 chr9:111667319 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 6.69 0.38 1.34e-10 Menarche (age at onset); CESC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg05313129 chr8:58192883 C8orf71 -0.5 -5.05 -0.3 8.06e-7 Developmental language disorder (linguistic errors); CESC cis rs17376456 1.000 rs17376207 chr5:93545524 C/T cg25358565 chr5:93447407 FAM172A -1.13 -11.09 -0.56 1e-23 Diabetic retinopathy; CESC cis rs4604732 0.631 rs74154676 chr1:247625894 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2228479 0.850 rs62056061 chr16:89901767 G/A cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs4835473 0.897 rs13114071 chr4:144656881 C/T cg25736465 chr4:144833511 NA -0.36 -5.52 -0.32 7.97e-8 Immature fraction of reticulocytes; CESC cis rs9796 0.611 rs691672 chr15:41444438 A/C cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.34 -0.36 9.71e-10 Menopause (age at onset); CESC cis rs11764590 0.694 rs10276536 chr7:2086960 C/T cg16393715 chr7:1948819 MAD1L1 -0.36 -5.06 -0.3 8e-7 Neuroticism; CESC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg00166722 chr3:10149974 C3orf24 0.45 5.72 0.33 2.8e-8 Alzheimer's disease; CESC cis rs947211 1.000 rs1775151 chr1:205745684 C/T cg26354017 chr1:205819088 PM20D1 0.4 5.04 0.3 8.8e-7 Parkinson's disease; CESC cis rs10489202 0.632 rs203779 chr1:167877647 T/G cg24449463 chr1:168025552 DCAF6 -0.43 -5.51 -0.32 8.36e-8 Schizophrenia; CESC cis rs7296418 0.885 rs1727305 chr12:123633382 T/C cg05973401 chr12:123451056 ABCB9 0.53 6.84 0.39 5.33e-11 Platelet count; CESC cis rs6500395 1.000 rs904819 chr16:48622583 C/A cg04672837 chr16:48644449 N4BP1 0.52 6.51 0.37 3.83e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg05457628 chr5:178986728 RUFY1 0.51 7.68 0.43 3.09e-13 Lung cancer; CESC cis rs1707322 1.000 rs12097799 chr1:46459886 C/A cg06784218 chr1:46089804 CCDC17 0.33 5.67 0.33 3.8e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4253772 0.591 rs9627324 chr22:46656511 A/G cg09491104 chr22:46646882 C22orf40 -0.6 -9.2 -0.49 1.09e-17 LDL cholesterol;Cholesterol, total; CESC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg07395648 chr5:131743802 NA -0.43 -5.66 -0.33 3.93e-8 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02066925 chr22:35936722 RASD2 -0.57 -6.49 -0.37 4.3e-10 Gut microbiome composition (summer); CESC cis rs1800795 0.652 rs7802307 chr7:22766433 T/A cg05265849 chr7:22767390 IL6 0.45 5.82 0.34 1.65e-8 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CESC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg15445000 chr17:37608096 MED1 0.4 6.47 0.37 4.81e-10 Glomerular filtration rate (creatinine); CESC cis rs7267979 0.932 rs449703 chr20:25458559 C/T cg08601574 chr20:25228251 PYGB 0.37 5.36 0.31 1.77e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg16145915 chr7:1198662 ZFAND2A -0.5 -6.29 -0.36 1.3e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11098499 0.644 rs28787668 chr4:120554687 G/A cg09307838 chr4:120376055 NA 0.77 10.24 0.53 5.82e-21 Corneal astigmatism; CESC cis rs10489525 0.599 rs910622 chr1:115600424 A/G cg01522456 chr1:115632236 TSPAN2 -0.48 -5.71 -0.33 2.96e-8 Autism; CESC cis rs8062405 0.756 rs151182 chr16:28495752 C/T cg08761264 chr16:28874980 SH2B1 -0.45 -5.34 -0.31 1.99e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs3780486 0.846 rs10813960 chr9:33180362 C/T cg13443165 chr9:33130375 B4GALT1 0.41 5.42 0.32 1.33e-7 IgG glycosylation; CESC cis rs6570726 0.935 rs446242 chr6:145843866 A/G cg23711669 chr6:146136114 FBXO30 0.78 11.38 0.57 1.07e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg16262614 chr3:133464971 TF 0.3 5.33 0.31 2.14e-7 Iron status biomarkers; CESC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.49 1.51e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.79 0.33 2.03e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg17971929 chr21:40555470 PSMG1 1.04 15.59 0.69 2.46e-39 Cognitive function; CESC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.56 0.37 2.89e-10 Prudent dietary pattern; CESC cis rs473651 0.935 rs35080527 chr2:239351387 T/C cg21699342 chr2:239360505 ASB1 0.54 9.21 0.49 1.05e-17 Multiple system atrophy; CESC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg17221315 chr6:27791827 HIST1H4J 0.43 5.15 0.3 4.98e-7 Parkinson's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12557418 chr8:110552613 EBAG9 -0.44 -6.24 -0.36 1.75e-9 Gambling; CESC cis rs6693567 0.565 rs698917 chr1:150319884 G/A cg09579323 chr1:150459698 TARS2 0.48 6.1 0.35 3.74e-9 Migraine; CESC cis rs9814567 1.000 rs9819532 chr3:134288644 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.05 -0.35 4.79e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4780401 0.728 rs8057398 chr16:11780629 G/T cg01061890 chr16:11836724 TXNDC11 -0.47 -6.19 -0.36 2.28e-9 Rheumatoid arthritis; CESC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg11890956 chr21:40555474 PSMG1 1.18 23.84 0.83 6.88e-68 Cognitive function; CESC cis rs950169 0.881 rs4842852 chr15:84941961 A/G cg17507749 chr15:85114479 UBE2QP1 0.59 6.52 0.37 3.46e-10 Schizophrenia; CESC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -6.73 -0.38 1.04e-10 Bipolar disorder; CESC cis rs9486715 0.929 rs7775721 chr6:97056979 C/T cg06623918 chr6:96969491 KIAA0776 -0.95 -14.69 -0.67 3.77e-36 Headache; CESC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2635047 0.967 rs1119005 chr18:44725605 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 6.48 0.37 4.57e-10 Educational attainment; CESC cis rs16895831 0.519 rs16895843 chr6:42541802 G/C cg10605015 chr6:42532144 UBR2 -0.52 -5.7 -0.33 3.23e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg12463550 chr7:65579703 CRCP -0.52 -6.63 -0.38 1.84e-10 Aortic root size; CESC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14516552 chr9:96213518 FAM120AOS;FAM120A -0.45 -6.38 -0.36 7.99e-10 Fibrinogen levels; CESC cis rs722599 0.715 rs2300598 chr14:75359229 T/C cg11812906 chr14:75593930 NEK9 -0.47 -5.58 -0.32 6.07e-8 IgG glycosylation; CESC cis rs6088590 1.000 rs55753039 chr20:33394940 C/T cg06115741 chr20:33292138 TP53INP2 0.62 7.42 0.41 1.59e-12 Coronary artery disease; CESC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg17971929 chr21:40555470 PSMG1 -0.87 -12.28 -0.6 9.54e-28 Cognitive function; CESC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg09658497 chr7:2847517 GNA12 0.43 6.12 0.35 3.33e-9 Height; CESC cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg03709012 chr19:19516395 GATAD2A 1.01 15.7 0.69 1.02e-39 Tonsillectomy; CESC cis rs4423214 0.592 rs11233977 chr11:71221605 C/T cg05163923 chr11:71159392 DHCR7 -0.55 -6.0 -0.35 6.31e-9 Vitamin D levels; CESC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg25767906 chr1:53392781 SCP2 -0.41 -5.07 -0.3 7.47e-7 Monocyte count; CESC cis rs9549260 0.591 rs9577108 chr13:41271764 G/A cg21288729 chr13:41239152 FOXO1 0.59 7.68 0.43 2.99e-13 Red blood cell count; CESC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg16145915 chr7:1198662 ZFAND2A -0.56 -8.69 -0.47 3.73e-16 Longevity;Endometriosis; CESC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg24829409 chr8:58192753 C8orf71 -0.67 -7.32 -0.41 3e-12 Developmental language disorder (linguistic errors); CESC cis rs2011503 1.000 rs11670761 chr19:19649327 G/C cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs6912958 0.781 rs2325064 chr6:88224467 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.51 -6.83 -0.39 5.94e-11 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07960067 chr2:9144629 MBOAT2 0.56 6.28 0.36 1.36e-9 Gut microbiome composition (summer); CESC cis rs887829 0.569 rs871514 chr2:234628529 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.52 -6.88 -0.39 4.26e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs2832191 0.935 rs11910316 chr21:30519729 G/A cg08807101 chr21:30365312 RNF160 -0.68 -9.36 -0.5 3.57e-18 Dental caries; CESC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.7 0.33 3.27e-8 Intelligence (multi-trait analysis); CESC cis rs6545883 0.965 rs6734830 chr2:61731112 G/A cg15711740 chr2:61764176 XPO1 -0.42 -5.3 -0.31 2.48e-7 Tuberculosis; CESC cis rs2710642 0.888 rs2539985 chr2:63134507 T/A cg17519650 chr2:63277830 OTX1 0.56 7.17 0.4 7.62e-12 LDL cholesterol levels;LDL cholesterol; CESC cis rs9837602 1.000 rs13323143 chr3:99811553 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 6.81 0.39 6.48e-11 Breast cancer; CESC cis rs4076764 1.000 rs12740984 chr1:163422151 A/G cg06092702 chr1:163392909 NA 0.39 5.68 0.33 3.5e-8 Motion sickness; CESC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 5.96 0.34 7.97e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1707322 0.721 rs10890337 chr1:46124527 C/T cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg05552183 chr6:42928497 GNMT 0.79 12.72 0.62 3.08e-29 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4803468 0.904 rs60781668 chr19:41944842 A/T cg14132834 chr19:41945861 ATP5SL 0.6 7.54 0.42 7.52e-13 Height; CESC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.68 0.64 1.34e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg26874164 chr19:58962979 ZNF324B 0.54 7.46 0.42 1.23e-12 Uric acid clearance; CESC cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg00825309 chr19:58991885 ZNF446 -0.54 -7.71 -0.43 2.62e-13 Uric acid clearance; CESC cis rs2439831 0.850 rs12441127 chr15:44021175 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.98 0.44 4.48e-14 Lung cancer in ever smokers; CESC cis rs116095464 0.558 rs7736600 chr5:231337 A/C cg22496380 chr5:211416 CCDC127 -0.74 -8.5 -0.46 1.44e-15 Breast cancer; CESC trans rs2727020 0.729 rs1917325 chr11:49370004 G/A cg03929089 chr4:120376271 NA -0.79 -11.97 -0.59 1.09e-26 Coronary artery disease; CESC cis rs6502050 0.761 rs9908277 chr17:80060829 T/C cg11859384 chr17:80120422 CCDC57 0.38 5.1 0.3 6.35e-7 Life satisfaction; CESC cis rs9916302 0.821 rs412430 chr17:37737094 C/G cg20243544 chr17:37824526 PNMT 0.55 6.8 0.39 6.87e-11 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.16 0.81 2.84e-62 Prudent dietary pattern; CESC cis rs6500395 0.802 rs13330784 chr16:48661530 A/C cg04672837 chr16:48644449 N4BP1 0.49 6.25 0.36 1.59e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs8002861 0.875 rs12867890 chr13:44423088 A/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.44 -5.51 -0.32 8.5e-8 Leprosy; CESC trans rs1973993 1.000 rs1973993 chr1:96943994 A/G cg10631902 chr5:14652156 NA 0.51 7.01 0.4 1.99e-11 Weight; CESC trans rs1814175 0.817 rs7947526 chr11:49983654 T/C cg03929089 chr4:120376271 NA -0.93 -15.75 -0.7 6.58e-40 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25166340 chr7:39605883 C7orf36 -0.45 -6.41 -0.37 6.5e-10 Fibrinogen levels; CESC cis rs763014 0.898 rs35666389 chr16:629458 A/G cg00802000 chr16:706648 WDR90 -0.42 -6.36 -0.36 9.01e-10 Height; CESC cis rs703842 1.000 rs703842 chr12:58162739 C/T cg18357645 chr12:58087776 OS9 0.36 5.17 0.3 4.71e-7 Multiple sclerosis; CESC cis rs8092503 1.000 rs6566870 chr18:52475860 C/G cg12377874 chr18:52495404 RAB27B -0.35 -5.99 -0.35 6.86e-9 Childhood body mass index; CESC cis rs4704187 0.687 rs1422699 chr5:74442410 G/A cg03227963 chr5:74354835 NA 0.3 5.58 0.32 5.99e-8 Response to amphetamines; CESC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 10.07 0.53 2.07e-20 Platelet count; CESC cis rs35955747 0.838 rs28716 chr22:31730189 A/C cg25791279 chr22:32026902 PISD 0.48 5.86 0.34 1.39e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs962856 0.619 rs6546301 chr2:67604239 G/A cg09028215 chr2:67624308 ETAA1 -0.43 -5.25 -0.31 3.17e-7 Pancreatic cancer; CESC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.77 10.11 0.53 1.58e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8058578 0.943 rs3747486 chr16:30786927 C/T cg00531865 chr16:30841666 NA -0.46 -6.23 -0.36 1.85e-9 Multiple myeloma; CESC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg01448562 chr3:133502909 NA -0.42 -5.81 -0.34 1.81e-8 Iron status biomarkers; CESC cis rs7829975 0.846 rs6601724 chr8:8544872 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -6.59 -0.38 2.35e-10 Mood instability; CESC cis rs2404602 0.669 rs12916324 chr15:77179603 G/A cg22467129 chr15:76604101 ETFA -0.35 -5.3 -0.31 2.45e-7 Blood metabolite levels; CESC cis rs2295359 0.892 rs72676058 chr1:67627681 C/A cg17031739 chr1:67600172 NA 0.4 5.22 0.31 3.68e-7 Psoriasis; CESC cis rs59698941 0.943 rs10491278 chr5:132220436 A/C cg02081065 chr5:132209139 LEAP2 -0.52 -5.11 -0.3 6.08e-7 Apolipoprotein A-IV levels; CESC cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg10578991 chr7:12443926 VWDE -0.51 -5.61 -0.33 5.17e-8 Coronary artery disease; CESC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg24060327 chr5:131705240 SLC22A5 -0.75 -10.38 -0.54 2.11e-21 Blood metabolite levels; CESC cis rs6912958 0.781 rs9450723 chr6:88226641 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.31 5.07 0.3 7.58e-7 Monocyte percentage of white cells; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg24528447 chr5:92918517 NR2F1 -0.4 -6.09 -0.35 3.9e-9 Vertical cup-disc ratio; CESC cis rs8018808 0.935 rs6574372 chr14:77906295 T/G cg20045696 chr14:77926864 AHSA1 0.42 5.79 0.33 2.03e-8 Myeloid white cell count; CESC cis rs523522 0.962 rs10849753 chr12:120910813 C/T cg12219531 chr12:120966889 COQ5 0.73 9.48 0.5 1.51e-18 High light scatter reticulocyte count; CESC cis rs2832191 1.000 rs9984793 chr21:30486471 T/C cg08807101 chr21:30365312 RNF160 -0.66 -9.01 -0.48 4.11e-17 Dental caries; CESC cis rs11098499 0.818 rs12498599 chr4:120468503 C/T cg24375607 chr4:120327624 NA 0.44 5.36 0.31 1.84e-7 Corneal astigmatism; CESC cis rs796364 0.806 rs112486506 chr2:201073947 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.77 -6.48 -0.37 4.42e-10 Schizophrenia; CESC cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg00701064 chr4:6280414 WFS1 0.69 11.97 0.59 1.14e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02918483 chr4:84406202 FAM175A 0.56 6.17 0.35 2.6e-9 Gut microbiome composition (summer); CESC cis rs16858210 0.874 rs10937153 chr3:183562925 A/G cg25686905 chr3:183603175 PARL 0.35 6.51 0.37 3.81e-10 Menopause (age at onset); CESC trans rs59827721 0.607 rs112865679 chr9:13855014 C/T cg27555582 chr12:22094009 NA -0.51 -6.01 -0.35 6.06e-9 Inflammatory skin disease; CESC cis rs5750830 0.620 rs1007337 chr22:39781585 C/T cg01416388 chr22:39784598 NA -0.53 -6.96 -0.39 2.66e-11 Intelligence (multi-trait analysis); CESC cis rs2295499 0.673 rs12506536 chr4:2712403 T/C cg27239842 chr4:2403781 ZFYVE28 -0.34 -5.66 -0.33 3.98e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs801193 1.000 rs10274773 chr7:66133578 G/A cg26939375 chr7:64535504 NA -0.64 -8.57 -0.47 8.53e-16 Aortic root size; CESC cis rs17641971 0.684 rs10957363 chr8:49999175 T/A cg00325661 chr8:49890786 NA 0.4 5.56 0.32 6.64e-8 Blood metabolite levels; CESC cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg08109568 chr15:31115862 NA -0.75 -9.74 -0.51 2.26e-19 Huntington's disease progression; CESC cis rs16854884 0.584 rs59768870 chr3:143738366 G/A cg06585982 chr3:143692056 C3orf58 0.5 6.46 0.37 4.94e-10 Economic and political preferences (feminism/equality); CESC cis rs1008375 0.931 rs10008337 chr4:17593849 G/C cg02297831 chr4:17616191 MED28 0.51 6.27 0.36 1.43e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6963495 0.818 rs73192144 chr7:105203535 C/T cg02135003 chr7:105160482 PUS7 -0.47 -5.61 -0.33 5.06e-8 Bipolar disorder (body mass index interaction); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03148428 chr7:156433416 C7orf13;RNF32 0.42 6.02 0.35 5.88e-9 Asthma; CESC cis rs10838687 0.800 rs58023804 chr11:47312374 A/G cg25783544 chr11:47291846 MADD 0.59 5.95 0.34 8.57e-9 Proinsulin levels; CESC cis rs6942756 0.737 rs61570833 chr7:128933492 C/A cg02491457 chr7:128862824 NA -0.69 -9.25 -0.49 7.66e-18 White matter hyperintensity burden; CESC cis rs7914558 0.966 rs12569617 chr10:104729996 T/C cg08650961 chr10:104748594 CNNM2 0.31 5.05 0.3 8.15e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs8017423 1.000 rs1959001 chr14:90667739 G/A cg14092571 chr14:90743983 NA -0.58 -8.7 -0.47 3.56e-16 Mortality in heart failure; CESC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg11663144 chr21:46675770 NA -0.62 -9.68 -0.51 3.55e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg05890377 chr2:74357713 NA 0.75 10.07 0.53 2.15e-20 Gestational age at birth (maternal effect); CESC cis rs6598955 0.671 rs12145403 chr1:26597189 C/T cg19743891 chr1:26644573 UBXN11;CD52 0.36 5.28 0.31 2.74e-7 Obesity-related traits; CESC cis rs7647973 0.587 rs10452032 chr3:49680973 G/A cg03060546 chr3:49711283 APEH 0.69 8.34 0.46 4.18e-15 Menarche (age at onset); CESC cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg00033643 chr7:134001901 SLC35B4 0.44 5.6 0.33 5.35e-8 Mean platelet volume; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03952484 chr1:149899818 SF3B4 0.45 6.24 0.36 1.77e-9 Systemic lupus erythematosus; CESC cis rs3862030 0.810 rs5870 chr10:104239100 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.38 -5.24 -0.31 3.36e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.46 6.39 0.37 7.27e-10 Menopause (age at onset); CESC cis rs9457247 1.000 rs416131 chr6:167406544 A/C cg25258033 chr6:167368657 RNASET2 -0.4 -6.07 -0.35 4.46e-9 Crohn's disease; CESC cis rs6087990 0.806 rs4911254 chr20:31357579 C/A cg13636640 chr20:31349939 DNMT3B 0.92 16.3 0.71 7.35e-42 Ulcerative colitis; CESC cis rs9894429 1.000 rs9894429 chr17:79596811 C/T cg21984481 chr17:79567631 NPLOC4 -0.49 -7.86 -0.43 9.77e-14 Eye color traits; CESC trans rs324780 0.544 rs324805 chr12:83931559 C/T cg22140261 chr22:42466895 NAGA -0.49 -6.24 -0.36 1.68e-9 Vertical cup-disc ratio; CESC cis rs4654899 1.000 rs12126133 chr1:21456537 T/C cg05370193 chr1:21551575 ECE1 0.41 6.2 0.36 2.2e-9 Superior frontal gyrus grey matter volume; CESC cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg02551604 chr5:131831745 NA -0.37 -5.22 -0.31 3.53e-7 Asthma (sex interaction); CESC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg04414720 chr1:150670196 GOLPH3L 0.62 9.16 0.49 1.47e-17 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20058270 chr6:43149950 CUL9 0.59 7.02 0.4 1.88e-11 Gut microbiome composition (summer); CESC cis rs60787346 0.883 rs2838334 chr21:45064961 A/G cg01579765 chr21:45077557 HSF2BP -0.35 -5.19 -0.3 4.12e-7 Coronary artery disease; CESC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg25036284 chr2:26402008 FAM59B -0.61 -7.08 -0.4 1.31e-11 Gut microbiome composition (summer); CESC cis rs6088580 0.634 rs4911152 chr20:32955024 T/C cg08999081 chr20:33150536 PIGU -0.65 -11.59 -0.58 2.17e-25 Glomerular filtration rate (creatinine); CESC cis rs9911578 1.000 rs9911578 chr17:56953147 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -6.96 -0.39 2.6e-11 Intelligence (multi-trait analysis); CESC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.13 -0.3 5.62e-7 Life satisfaction; CESC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg12373951 chr3:133503437 NA -0.35 -5.14 -0.3 5.46e-7 Iron status biomarkers; CESC cis rs7577696 0.539 rs2280972 chr2:32377961 C/T cg02381751 chr2:32503542 YIPF4 -0.46 -5.04 -0.3 8.51e-7 Inflammatory biomarkers; CESC cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg21918786 chr6:109611834 NA -0.35 -5.03 -0.3 8.9e-7 Reticulocyte fraction of red cells; CESC cis rs28374715 0.578 rs8036026 chr15:41630499 C/G cg18705301 chr15:41695430 NDUFAF1 -1.06 -15.7 -0.69 1.03e-39 Ulcerative colitis; CESC cis rs881375 0.678 rs7031752 chr9:123663482 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 6.62 0.38 1.99e-10 Rheumatoid arthritis; CESC cis rs12476592 0.602 rs6546018 chr2:63817422 G/T cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg11494091 chr17:61959527 GH2 0.63 10.06 0.53 2.26e-20 Prudent dietary pattern; CESC cis rs6963495 0.745 rs73190179 chr7:105162812 C/A cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs4588572 0.643 rs6453391 chr5:77755035 T/C cg11547950 chr5:77652471 NA -0.44 -5.48 -0.32 9.67e-8 Triglycerides; CESC cis rs2230307 0.536 rs834164 chr1:100603948 A/C cg24955406 chr1:100503596 HIAT1 -0.51 -5.43 -0.32 1.26e-7 Carotid intima media thickness; CESC cis rs1023500 0.573 rs2269524 chr22:42475703 T/G cg04733989 chr22:42467013 NAGA -0.83 -12.7 -0.62 3.37e-29 Schizophrenia; CESC cis rs6430585 0.528 rs16832440 chr2:136754183 G/A cg07169764 chr2:136633963 MCM6 1.27 17.1 0.72 1.1e-44 Corneal structure; CESC cis rs651907 0.557 rs1031710 chr3:101463895 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.88 0.34 1.22e-8 Colorectal cancer; CESC cis rs6912958 0.781 rs9450738 chr6:88267314 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.57 -0.37 2.58e-10 Monocyte percentage of white cells; CESC cis rs3087591 0.960 rs11080146 chr17:29578724 C/T cg24425628 chr17:29625626 OMG;NF1 -0.41 -5.04 -0.3 8.56e-7 Hip circumference; CESC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg06636001 chr8:8085503 FLJ10661 -0.45 -5.86 -0.34 1.34e-8 Mood instability; CESC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg05132306 chr1:1846340 CALML6 -0.3 -6.27 -0.36 1.44e-9 Body mass index; CESC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg10150615 chr22:24372951 LOC391322 -0.54 -7.24 -0.41 4.97e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs56313388 0.521 rs62039274 chr16:56328813 G/T cg02433656 chr16:56322654 GNAO1 0.45 5.55 0.32 6.79e-8 Pulse pressure; CESC cis rs4704187 0.687 rs10462513 chr5:74422607 C/T cg03227963 chr5:74354835 NA 0.31 5.67 0.33 3.69e-8 Response to amphetamines; CESC cis rs73019876 0.869 rs2522095 chr19:22124067 T/G cg11619707 chr19:22235551 ZNF257 -0.31 -5.78 -0.33 2.11e-8 Testicular germ cell tumor; CESC cis rs3091242 0.933 rs35530120 chr1:25785451 A/G cg03538708 chr1:25844672 NA 0.38 5.79 0.34 1.98e-8 Erythrocyte sedimentation rate; CESC trans rs9467711 0.606 rs12173854 chr6:26371679 A/G cg06606381 chr12:133084897 FBRSL1 -0.76 -6.89 -0.39 4.1e-11 Autism spectrum disorder or schizophrenia; CESC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg17949981 chr6:28129498 ZNF389 0.39 5.08 0.3 7.23e-7 Parkinson's disease; CESC cis rs2228479 0.867 rs57940434 chr16:89975496 G/A cg00800038 chr16:89945340 TCF25 -0.75 -7.05 -0.4 1.54e-11 Skin colour saturation; CESC cis rs9291683 0.588 rs3733586 chr4:9997534 C/T cg11266682 chr4:10021025 SLC2A9 0.67 13.52 0.64 4.92e-32 Bone mineral density; CESC cis rs2075371 0.796 rs1646644 chr7:134011817 A/T cg20476274 chr7:133979776 SLC35B4 0.55 7.51 0.42 9e-13 Mean platelet volume; CESC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg02725872 chr8:58115012 NA -0.34 -5.32 -0.31 2.18e-7 Developmental language disorder (linguistic errors); CESC cis rs933688 1.000 rs6452953 chr5:90723034 T/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.11 14.8 0.67 1.56e-36 Smoking behavior; CESC cis rs523522 0.926 rs10774555 chr12:120971978 G/A cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg02725872 chr8:58115012 NA -0.44 -6.88 -0.39 4.33e-11 Developmental language disorder (linguistic errors); CESC cis rs7116495 0.609 rs2503 chr11:71719403 C/T cg10381502 chr11:71823885 C11orf51 1.11 7.91 0.44 7.18e-14 Severe influenza A (H1N1) infection; CESC cis rs763121 0.853 rs1056610 chr22:39080078 C/T cg06544989 chr22:39130855 UNC84B -0.52 -9.7 -0.51 3.19e-19 Menopause (age at onset); CESC cis rs9329289 0.603 rs2458698 chr10:2548452 C/T cg05625103 chr10:2543513 NA 0.51 7.11 0.4 1.09e-11 Age-related hearing impairment; CESC cis rs3820068 0.603 rs3766163 chr1:15986547 T/C cg16988262 chr1:15930761 NA 0.35 5.81 0.34 1.83e-8 Systolic blood pressure; CESC cis rs523522 0.962 rs10774549 chr12:120891172 C/T cg12219531 chr12:120966889 COQ5 0.72 9.05 0.49 3.08e-17 High light scatter reticulocyte count; CESC trans rs1814175 0.869 rs10769600 chr11:49681832 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -17.79 -0.74 4.04e-47 Height; CESC cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg03467027 chr4:99064603 C4orf37 0.44 5.56 0.32 6.75e-8 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13751213 chr7:148581913 EZH2 -0.47 -6.11 -0.35 3.57e-9 Ulcerative colitis; CESC cis rs2645694 0.533 rs2703125 chr4:77819900 T/C cg10057126 chr4:77819792 ANKRD56 0.59 8.66 0.47 4.84e-16 Emphysema distribution in smoking; CESC cis rs4819052 0.788 rs13049700 chr21:46701909 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.6 7.58 0.42 5.8e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19886613 chr18:61089605 VPS4B 0.58 6.82 0.39 6.27e-11 Gut microbiome composition (summer); CESC cis rs12765878 0.967 rs10883940 chr10:105650598 G/A cg11005552 chr10:105648138 OBFC1 0.36 5.24 0.31 3.32e-7 Coronary artery disease; CESC cis rs3106136 0.527 rs2865345 chr4:95156565 A/G cg11021082 chr4:95130006 SMARCAD1 -0.65 -10.45 -0.54 1.22e-21 Capecitabine sensitivity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00127214 chr14:36295713 BRMS1L 0.5 6.65 0.38 1.67e-10 Gut microbiota (bacterial taxa); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg05865202 chr20:36156789 BLCAP 0.46 6.01 0.35 6.24e-9 Breast cancer;Type 2 diabetes; CESC cis rs10465746 0.780 rs7550413 chr1:84423891 T/A cg10977910 chr1:84465055 TTLL7 0.52 7.01 0.4 2.02e-11 Obesity-related traits; CESC cis rs2625529 0.689 rs12898728 chr15:72112853 C/T cg16672083 chr15:72433130 SENP8 -0.52 -7.9 -0.44 7.36e-14 Red blood cell count; CESC cis rs7818345 0.967 rs4617172 chr8:19273362 G/A cg11303988 chr8:19266685 CSGALNACT1 0.31 5.43 0.32 1.28e-7 Language performance in older adults (adjusted for episodic memory); CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg26939375 chr7:64535504 NA 0.67 9.74 0.51 2.4e-19 Calcium levels; CESC cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg05347473 chr6:146136440 FBXO30 0.58 7.33 0.41 2.84e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs17253792 0.822 rs75399477 chr14:56174413 T/C cg01858014 chr14:56050164 KTN1 -0.96 -7.37 -0.41 2.12e-12 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27123106 chr10:855660 LARP4B -0.72 -7.86 -0.43 9.84e-14 Gut microbiome composition (summer); CESC cis rs9908102 0.740 rs58809197 chr17:12920260 A/G cg26162695 chr17:12921313 ELAC2 0.58 6.18 0.35 2.47e-9 Schizophrenia; CESC trans rs7824557 0.564 rs2572389 chr8:11236392 T/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.15 -0.35 2.9e-9 Retinal vascular caliber; CESC cis rs4474465 0.790 rs4944206 chr11:78263127 T/C cg27205649 chr11:78285834 NARS2 0.41 5.27 0.31 2.81e-7 Alzheimer's disease (survival time); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27130364 chr5:36151796 LMBRD2;SKP2 0.54 6.16 0.35 2.7e-9 Gut microbiome composition (summer); CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg04234412 chr22:24373322 LOC391322 -0.65 -9.72 -0.51 2.72e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1348850 0.793 rs13020788 chr2:178480714 C/A cg23306229 chr2:178417860 TTC30B 0.53 6.78 0.38 7.89e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs4904167 0.841 rs1462340 chr14:84676912 T/C cg06870609 chr15:89787223 FANCI 0.46 6.04 0.35 5.27e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg21285383 chr16:89894308 SPIRE2 0.3 5.35 0.31 1.87e-7 Vitiligo; CESC cis rs3820068 0.581 rs16851876 chr1:15950628 A/T cg18133145 chr1:16060689 PLEKHM2 0.4 5.09 0.3 6.88e-7 Systolic blood pressure; CESC cis rs67311347 1.000 rs9849992 chr3:40402140 C/T cg24209194 chr3:40518798 ZNF619 0.42 5.33 0.31 2.12e-7 Renal cell carcinoma; CESC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg23708337 chr7:1209742 NA 0.52 5.19 0.3 4.12e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs12492269 0.702 rs41381644 chr3:178161614 A/G cg13389611 chr3:179370465 USP13 -0.73 -6.01 -0.35 6.06e-9 Plasma clusterin levels; CESC cis rs7605827 0.930 rs12692260 chr2:15511809 A/G cg19274914 chr2:15703543 NA 0.32 5.58 0.32 5.95e-8 Educational attainment (years of education); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09854653 chr6:163834903 QKI -0.5 -6.03 -0.35 5.63e-9 Ulcerative colitis; CESC cis rs2404602 0.716 rs12441550 chr15:76863682 A/T cg22467129 chr15:76604101 ETFA -0.35 -5.24 -0.31 3.24e-7 Blood metabolite levels; CESC cis rs9814567 1.000 rs934093 chr3:134195885 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.41 -0.37 6.66e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs4596713 0.538 rs10781456 chr9:71782869 G/A cg16512924 chr15:28394682 HERC2 0.48 6.1 0.35 3.71e-9 Headache; CESC cis rs367943 0.965 rs644154 chr5:112799080 G/T cg12552261 chr5:112820674 MCC -0.62 -7.68 -0.43 3.04e-13 Type 2 diabetes; CESC cis rs11608355 0.515 rs35691047 chr12:109932585 C/T cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg25124228 chr12:125621409 AACS 0.49 5.83 0.34 1.58e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg08392591 chr16:89556376 ANKRD11 0.67 9.05 0.49 3.17e-17 Multiple myeloma (IgH translocation); CESC cis rs1878931 0.668 rs2074366 chr16:3439676 G/A cg21433313 chr16:3507492 NAT15 -0.36 -5.35 -0.31 1.94e-7 Body mass index (adult); CESC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg12718519 chr1:2058417 PRKCZ -0.25 -5.48 -0.32 9.73e-8 Height; CESC cis rs977987 0.931 rs7195161 chr16:75495572 T/C cg03315344 chr16:75512273 CHST6 0.55 8.01 0.44 3.67e-14 Dupuytren's disease; CESC cis rs644799 0.965 rs10831425 chr11:95500628 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.72 9.85 0.52 1.06e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10743315 0.557 rs78983750 chr12:19284967 C/T cg02471346 chr12:19282374 PLEKHA5 0.71 5.34 0.31 1.96e-7 Gut microbiota (bacterial taxa); CESC cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg11657440 chr19:46296263 DMWD 0.86 12.95 0.62 4.58e-30 Coronary artery disease; CESC cis rs8114671 0.527 rs6088650 chr20:33514465 C/T cg06115741 chr20:33292138 TP53INP2 -0.48 -5.9 -0.34 1.13e-8 Height; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01931797 chr11:77899910 KCTD21;USP35 0.46 6.37 0.36 8.39e-10 Intelligence (multi-trait analysis); CESC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.86 0.34 1.4e-8 Electroencephalogram traits; CESC cis rs2354432 0.556 rs7516165 chr1:146866418 G/T cg25205988 chr1:146714368 CHD1L 1.01 8.88 0.48 1.06e-16 Mitochondrial DNA levels; CESC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg26314531 chr2:26401878 FAM59B -0.75 -7.66 -0.43 3.48e-13 Gut microbiome composition (summer); CESC cis rs7824557 0.547 rs2409745 chr8:11076635 G/T cg21775007 chr8:11205619 TDH 0.39 5.58 0.32 6.04e-8 Retinal vascular caliber; CESC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg22535103 chr8:58192502 C8orf71 -1.07 -13.57 -0.64 3.2e-32 Developmental language disorder (linguistic errors); CESC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.98 0.34 7.35e-9 Tonsillectomy; CESC cis rs6460942 0.915 rs10267801 chr7:12451931 G/A cg16278512 chr7:12443529 VWDE -0.5 -5.84 -0.34 1.53e-8 Coronary artery disease; CESC cis rs1775715 0.835 rs11008701 chr10:32241096 A/G cg18675610 chr10:32216311 ARHGAP12 0.33 5.18 0.3 4.45e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg02951883 chr7:2050386 MAD1L1 -0.4 -5.12 -0.3 5.76e-7 Bipolar disorder and schizophrenia; CESC cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg12365402 chr11:9010492 NRIP3 -0.33 -5.31 -0.31 2.27e-7 Hemoglobin concentration; CESC cis rs6980507 0.523 rs2974293 chr8:42369455 C/T cg09913449 chr8:42400586 C8orf40 -0.34 -5.4 -0.31 1.48e-7 Glycated hemoglobin levels; CESC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg07507251 chr3:52567010 NT5DC2 0.41 7.19 0.4 6.62e-12 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11296937 chr11:64084966 PRDX5;TRMT112 -0.46 -6.7 -0.38 1.28e-10 Fibrinogen levels; CESC cis rs238295 0.766 rs6038204 chr20:5549071 T/A cg24001556 chr20:5591874 RP5-1022P6.2 -0.46 -5.11 -0.3 6.12e-7 Occipital cortical area (total cortical area interaction); CESC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg06505273 chr16:24850292 NA 0.51 5.84 0.34 1.56e-8 Intelligence (multi-trait analysis); CESC cis rs6540559 0.673 rs7511996 chr1:210018473 C/A cg23283495 chr1:209979779 IRF6 0.48 5.61 0.33 5.1e-8 Cleft lip with or without cleft palate; CESC cis rs3820928 0.874 rs10169717 chr2:227796911 T/G cg11843606 chr2:227700838 RHBDD1 -0.43 -5.75 -0.33 2.45e-8 Pulmonary function; CESC cis rs9858542 0.953 rs9824092 chr3:49674147 C/G cg07274523 chr3:49395745 GPX1 0.68 8.72 0.47 3.23e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03217679 chr4:73935524 COX18 -0.48 -6.12 -0.35 3.29e-9 Fibrinogen levels; CESC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs2243480 0.711 rs2460426 chr7:65623129 A/G cg13147721 chr7:65941812 NA 0.97 9.19 0.49 1.2e-17 Diabetic kidney disease; CESC cis rs2295359 0.892 rs2064689 chr1:67653010 G/A cg17031739 chr1:67600172 NA 0.41 5.43 0.32 1.28e-7 Psoriasis; CESC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.51 0.46 1.33e-15 Colonoscopy-negative controls vs population controls; CESC cis rs73206853 0.698 rs1018134 chr12:111121119 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 5.79 0.33 2.02e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7662987 0.517 rs1154406 chr4:100008494 T/C cg13256891 chr4:100009986 ADH5 0.75 8.06 0.44 2.55e-14 Smoking initiation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01539269 chr19:18746992 KLHL26 -0.56 -6.51 -0.37 3.68e-10 Gut microbiome composition (summer); CESC cis rs922182 0.633 rs4776700 chr15:64270861 A/T cg24729988 chr15:64271149 DAPK2 -0.47 -6.63 -0.38 1.84e-10 Blood protein levels; CESC cis rs10484885 0.878 rs111664889 chr6:90566427 G/T cg13799429 chr6:90582589 CASP8AP2 -0.76 -7.22 -0.41 5.66e-12 QRS interval (sulfonylurea treatment interaction); CESC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg25767906 chr1:53392781 SCP2 -0.4 -5.16 -0.3 4.92e-7 Monocyte count; CESC trans rs10958369 0.541 rs1477955 chr8:54435226 T/C cg05787952 chr16:734667 JMJD8 0.44 6.22 0.36 1.93e-9 Response to antineoplastic agents; CESC cis rs1728785 0.901 rs1183956 chr16:68606726 G/A cg02972257 chr16:68554789 NA -0.59 -6.71 -0.38 1.2e-10 Ulcerative colitis; CESC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg21770322 chr7:97807741 LMTK2 0.55 8.31 0.45 4.96e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs6582630 0.573 rs12319414 chr12:38267440 T/C cg26384229 chr12:38710491 ALG10B -0.46 -6.06 -0.35 4.62e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg19622623 chr12:86230825 RASSF9 -0.47 -5.96 -0.34 7.92e-9 Major depressive disorder; CESC cis rs7845219 0.525 rs7820818 chr8:95919231 G/A cg09323728 chr8:95962352 TP53INP1 -0.34 -6.56 -0.37 2.83e-10 Type 2 diabetes; CESC trans rs7726839 0.540 rs11739847 chr5:609661 G/A cg25482853 chr8:67687455 SGK3 1.02 9.93 0.52 5.72e-20 Obesity-related traits; CESC cis rs4901869 0.902 rs10149194 chr14:59308198 A/G cg02291164 chr14:59296302 NA -0.43 -7.5 -0.42 9.57e-13 Panic disorder; CESC cis rs79387448 0.626 rs80277428 chr2:103080056 G/A cg09003973 chr2:102972529 NA 1.09 8.16 0.45 1.39e-14 Gut microbiota (bacterial taxa); CESC cis rs9527 0.637 rs11191424 chr10:104625886 G/A cg04362960 chr10:104952993 NT5C2 0.52 6.38 0.36 7.96e-10 Arsenic metabolism; CESC cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg01579765 chr21:45077557 HSF2BP -0.57 -9.52 -0.5 1.15e-18 Mean corpuscular volume; CESC trans rs1994135 0.617 rs10844644 chr12:33735871 A/G cg26384229 chr12:38710491 ALG10B 0.45 6.5 0.37 3.96e-10 Resting heart rate; CESC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.53 8.0 0.44 3.86e-14 Bipolar disorder; CESC cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.3 -5.22 -0.31 3.6e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs477692 0.673 rs1970197 chr10:131359588 C/T cg05714579 chr10:131428358 MGMT 0.41 5.38 0.31 1.63e-7 Response to temozolomide; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg14195823 chr19:39926698 RPS16 0.48 6.19 0.36 2.32e-9 Bronchopulmonary dysplasia; CESC cis rs4604732 0.588 rs7552461 chr1:247628644 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.09 0.3 6.91e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02820613 chr16:30538074 ZNF768 0.61 6.87 0.39 4.44e-11 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs62054257 chr16:89900195 G/A cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg26314531 chr2:26401878 FAM59B -0.77 -8.56 -0.47 9.38e-16 Gut microbiome composition (summer); CESC cis rs4563143 0.502 rs73029061 chr19:29283980 T/A cg12756686 chr19:29218302 NA 0.55 6.67 0.38 1.51e-10 Methadone dose in opioid dependence; CESC cis rs17376456 0.825 rs28645862 chr5:93233128 G/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.24 0.31 3.31e-7 Diabetic retinopathy; CESC cis rs11997175 0.819 rs6415400 chr8:33783714 C/T ch.8.33884649F chr8:33765107 NA 0.73 10.48 0.54 1.03e-21 Body mass index; CESC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg22143856 chr6:28129313 ZNF389 0.38 5.38 0.31 1.6e-7 Cardiac Troponin-T levels; CESC cis rs977987 0.806 rs11642572 chr16:75452782 C/T cg03315344 chr16:75512273 CHST6 0.41 5.84 0.34 1.56e-8 Dupuytren's disease; CESC cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg20476274 chr7:133979776 SLC35B4 0.59 8.11 0.45 1.89e-14 Mean platelet volume; CESC cis rs561341 1.000 rs530209 chr17:30315287 A/G cg19193384 chr17:30244184 NA -0.67 -6.36 -0.36 8.74e-10 Hip circumference adjusted for BMI; CESC cis rs7044106 0.537 rs10739573 chr9:123489818 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 7.99 0.44 4.25e-14 Hip circumference adjusted for BMI; CESC cis rs870825 0.655 rs67380800 chr4:185623788 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg12463550 chr7:65579703 CRCP -0.48 -5.91 -0.34 1.05e-8 Aortic root size; CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.38 0.36 7.82e-10 Bipolar disorder; CESC cis rs2073300 1.000 rs6132621 chr20:23442180 C/T cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs9929218 0.539 rs1125557 chr16:68809599 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.86 13.93 0.65 1.77e-33 Colorectal cancer; CESC cis rs739401 0.572 rs384490 chr11:3078885 A/C cg08508325 chr11:3079039 CARS -0.58 -11.24 -0.57 3.11e-24 Longevity; CESC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.78 0.47 2.06e-16 Bipolar disorder; CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg05564831 chr3:52568323 NT5DC2 0.51 8.61 0.47 6.6e-16 Electroencephalogram traits; CESC cis rs7100689 0.622 rs1417221 chr10:82100428 G/A cg00277334 chr10:82204260 NA -0.61 -8.03 -0.44 3.17e-14 Post bronchodilator FEV1; CESC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs35110281 0.743 rs2329443 chr21:45059431 C/T cg04455712 chr21:45112962 RRP1B 0.4 5.76 0.33 2.38e-8 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00053086 chr1:233119296 NA -0.52 -6.22 -0.36 1.95e-9 Gut microbiome composition (summer); CESC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg13206674 chr6:150067644 NUP43 0.42 5.81 0.34 1.75e-8 Lung cancer; CESC cis rs1045714 1.000 rs1045714 chr7:2653582 A/G cg20813462 chr7:2646259 IQCE 0.71 5.79 0.34 1.98e-8 Urate levels in lean individuals; CESC cis rs10927875 0.662 rs848309 chr1:16308447 T/C cg22431228 chr1:16359049 CLCNKA -0.45 -8.45 -0.46 1.99e-15 Dilated cardiomyopathy; CESC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg02187348 chr16:89574699 SPG7 0.7 10.19 0.53 8.74e-21 Multiple myeloma (IgH translocation); CESC cis rs7103648 0.966 rs10838702 chr11:47410888 G/T cg20307385 chr11:47447363 PSMC3 0.89 14.12 0.66 3.98e-34 Diastolic blood pressure;Systolic blood pressure; CESC cis rs5997397 1.000 rs5997397 chr22:29154455 A/G cg15103426 chr22:29168792 CCDC117 0.45 6.0 0.35 6.59e-9 Red cell distribution width; CESC cis rs9611565 0.506 rs2024566 chr22:41697338 A/G cg06634786 chr22:41940651 POLR3H -0.5 -5.35 -0.31 1.91e-7 Vitiligo; CESC cis rs9297145 0.916 rs4236540 chr7:98769025 A/C cg05967295 chr7:98741636 SMURF1 0.91 12.21 0.6 1.68e-27 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs2228479 0.717 rs12917681 chr16:89810941 C/A cg04013166 chr16:89971882 TCF25 0.71 7.73 0.43 2.28e-13 Skin colour saturation; CESC cis rs4925386 0.840 rs6142738 chr20:60919960 C/T cg24112000 chr20:60950667 NA 0.45 5.69 0.33 3.33e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg22029157 chr1:209979665 IRF6 0.69 10.11 0.53 1.57e-20 Cleft lip with or without cleft palate; CESC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg14196790 chr5:131705035 SLC22A5 0.32 5.2 0.3 4.03e-7 Breast cancer; CESC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg02375832 chr11:62437615 C11orf48 -0.38 -5.48 -0.32 9.85e-8 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs13095912 1.000 rs9714158 chr3:185328780 C/T cg11274856 chr3:185301563 NA 0.35 5.5 0.32 8.96e-8 Systolic blood pressure; CESC cis rs12586317 0.534 rs2273157 chr14:35438836 A/G cg05294307 chr14:35346193 BAZ1A -0.5 -6.39 -0.37 7.53e-10 Psoriasis; CESC cis rs12048904 0.619 rs10875347 chr1:101333737 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.88 12.02 0.59 7.32e-27 Multiple sclerosis; CESC cis rs4237845 1.000 rs4237845 chr12:58302436 A/G cg02175503 chr12:58329896 NA -0.66 -8.84 -0.48 1.4e-16 Intelligence (multi-trait analysis); CESC cis rs10979 0.894 rs6924940 chr6:143906183 C/T cg25407410 chr6:143891975 LOC285740 -0.59 -8.51 -0.46 1.29e-15 Hypospadias; CESC cis rs2629540 0.847 rs11245342 chr10:126414084 C/T cg08799069 chr10:126477246 METTL10 0.58 7.33 0.41 2.73e-12 Cocaine dependence; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02675260 chr11:64135691 MIR1237;RPS6KA4 0.54 7.44 0.42 1.4e-12 Fibrinogen levels; CESC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg08704250 chr15:31115839 NA -0.68 -9.12 -0.49 1.97e-17 Huntington's disease progression; CESC cis rs10129255 0.500 rs2027902 chr14:107215393 T/C cg23076370 chr14:107095027 NA -0.63 -8.89 -0.48 9.53e-17 Kawasaki disease; CESC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.4 -0.57 9.17e-25 Type 2 diabetes; CESC cis rs7255436 0.965 rs7351098 chr19:8451671 G/C cg10174797 chr19:8464628 RAB11B 0.39 5.57 0.32 6.11e-8 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16010370 chr3:53290200 TKT -0.65 -7.9 -0.44 7.36e-14 Gut microbiome composition (summer); CESC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg23034840 chr1:205782522 SLC41A1 0.68 8.43 0.46 2.21e-15 Menarche (age at onset); CESC cis rs2073300 0.609 rs3827086 chr20:23357331 C/T cg16736954 chr20:23401023 NAPB 0.8 6.09 0.35 3.89e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg26314531 chr2:26401878 FAM59B -0.61 -6.93 -0.39 3.12e-11 Gut microbiome composition (summer); CESC cis rs11166927 0.967 rs12680346 chr8:140814379 C/T cg16909799 chr8:140841666 TRAPPC9 0.47 6.9 0.39 3.74e-11 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs9388451 0.874 rs7739566 chr6:126094757 A/T cg05901451 chr6:126070800 HEY2 -0.63 -9.26 -0.49 7.05e-18 Brugada syndrome; CESC cis rs7267979 1.000 rs6115168 chr20:25372891 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.35e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs2404602 0.655 rs4886824 chr15:76969256 A/G cg26408565 chr15:76604113 ETFA -0.39 -5.71 -0.33 2.98e-8 Blood metabolite levels; CESC cis rs5769765 0.954 rs1569954 chr22:50244071 C/T cg02269571 chr22:50332266 NA 0.46 6.07 0.35 4.43e-9 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15420520 chr20:55043481 C20orf43 -0.41 -6.2 -0.36 2.11e-9 Gambling; CESC cis rs9325144 0.560 rs7314632 chr12:38636979 C/T cg26384229 chr12:38710491 ALG10B -0.59 -9.2 -0.49 1.07e-17 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07434447 chr7:74489725 WBSCR16 0.64 7.37 0.41 2.24e-12 Gut microbiome composition (summer); CESC cis rs3824344 0.531 rs7870336 chr9:37007769 C/G cg14294708 chr9:37120828 ZCCHC7 -0.4 -5.13 -0.3 5.54e-7 Intelligence; CESC cis rs12762955 0.561 rs7075141 chr10:1091195 C/T cg10556349 chr10:835070 NA -0.42 -5.16 -0.3 4.83e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs2439831 0.850 rs12442129 chr15:44055856 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.76 0.38 8.72e-11 Lung cancer in ever smokers; CESC cis rs2415984 0.622 rs73245837 chr14:46947914 A/G cg14871534 chr14:47121158 RPL10L -0.37 -5.64 -0.33 4.47e-8 Number of children ever born; CESC cis rs7799006 0.723 rs2270052 chr7:2291399 C/T cg12823233 chr7:2316876 SNX8 -0.3 -5.1 -0.3 6.6e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12477438 0.765 rs17708262 chr2:99696313 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.57 -0.47 8.65e-16 Chronic sinus infection; CESC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg22535103 chr8:58192502 C8orf71 -1.04 -12.84 -0.62 1.16e-29 Developmental language disorder (linguistic errors); CESC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg12311346 chr5:56204834 C5orf35 -0.71 -8.43 -0.46 2.24e-15 Initial pursuit acceleration; CESC cis rs2228479 0.681 rs8044906 chr16:89969603 T/C cg00800038 chr16:89945340 TCF25 -0.57 -6.03 -0.35 5.45e-9 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00026974 chr17:42298151 UBTF 0.54 6.28 0.36 1.36e-9 Gut microbiome composition (summer); CESC cis rs1124376 1.000 rs9819628 chr3:20140837 A/G cg05072819 chr3:20081367 KAT2B -0.48 -5.4 -0.31 1.5e-7 Bipolar disorder and schizophrenia; CESC trans rs10074525 0.885 rs17633498 chr5:90276385 A/G cg22855255 chr17:50237267 CA10 -0.34 -6.05 -0.35 5.03e-9 Obesity-related traits; CESC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg13206674 chr6:150067644 NUP43 0.43 6.17 0.35 2.58e-9 Lung cancer; CESC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg05617483 chr15:76483344 C15orf27 0.41 5.57 0.32 6.17e-8 Blood metabolite levels; CESC cis rs4629180 1.000 rs11123889 chr2:102107180 G/A cg01388757 chr2:102091195 RFX8 0.45 6.67 0.38 1.45e-10 Chronic rhinosinusitis with nasal polyps; CESC cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg10556349 chr10:835070 NA 0.55 5.39 0.31 1.54e-7 Eosinophil percentage of granulocytes; CESC cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg18357645 chr12:58087776 OS9 0.43 6.1 0.35 3.79e-9 Multiple sclerosis; CESC cis rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04799588 chr10:6263484 PFKFB3 -0.38 -5.11 -0.3 6.28e-7 Gut microbiota (bacterial taxa); CESC cis rs1881797 1.000 rs1881797 chr1:247689532 A/G cg11166453 chr1:247681781 NA 0.4 5.96 0.34 8.17e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs7937682 0.921 rs4616071 chr11:111440865 C/G cg22437258 chr11:111473054 SIK2 -0.65 -7.0 -0.39 2.15e-11 Primary sclerosing cholangitis; CESC cis rs3768617 0.510 rs10797837 chr1:183075121 C/G ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.05e-34 Fuchs's corneal dystrophy; CESC cis rs2073300 0.609 rs6137929 chr20:23376357 G/A cg12062639 chr20:23401060 NAPB 1.07 8.85 0.48 1.29e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg18252515 chr7:66147081 NA -0.39 -5.18 -0.3 4.4e-7 Aortic root size; CESC cis rs10870270 0.913 rs4880326 chr10:133745547 C/A cg08754478 chr10:133766260 PPP2R2D -0.61 -7.93 -0.44 6.3e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs4819052 0.590 rs414743 chr21:46512075 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.59 6.43 0.37 5.99e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4664308 0.935 rs4292050 chr2:160940899 G/T cg03641300 chr2:160917029 PLA2R1 -0.67 -9.84 -0.52 1.11e-19 Idiopathic membranous nephropathy; CESC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs765787 0.530 rs2899378 chr15:45537584 C/T cg24006582 chr15:45444508 DUOX1 0.57 6.91 0.39 3.55e-11 Uric acid levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25195100 chr20:61903949 ARFGAP1 -0.48 -6.28 -0.36 1.37e-9 Ulcerative colitis; CESC cis rs4803468 1.000 rs878082 chr19:41897674 G/A cg09537434 chr19:41945824 ATP5SL -1.02 -18.17 -0.74 1.81e-48 Height; CESC cis rs7615952 0.673 rs35001498 chr3:125628644 A/G cg05084668 chr3:125655381 ALG1L -0.77 -8.05 -0.44 2.74e-14 Blood pressure (smoking interaction); CESC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg21433313 chr16:3507492 NAT15 0.51 8.48 0.46 1.56e-15 Tuberculosis; CESC cis rs4953076 0.573 rs920519 chr2:44452344 T/C cg04920474 chr2:44395004 PPM1B 0.51 6.65 0.38 1.72e-10 Height; CESC cis rs4819052 0.679 rs2255761 chr21:46683622 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.71 0.33 3.04e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9611565 0.840 rs2234052 chr22:41777241 A/G cg06481639 chr22:41940642 POLR3H -0.6 -6.44 -0.37 5.59e-10 Vitiligo; CESC cis rs921968 0.565 rs7603709 chr2:219642601 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -7.51 -0.42 9.29e-13 Mean corpuscular hemoglobin concentration; CESC cis rs10870270 1.000 rs3935905 chr10:133758262 A/C cg08754478 chr10:133766260 PPP2R2D -0.59 -7.69 -0.43 2.86e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1062746 0.777 rs34400756 chr16:87372078 A/G cg02258303 chr16:87377426 FBXO31 -0.51 -6.5 -0.37 3.96e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CESC trans rs3780486 0.846 rs7865745 chr9:33140976 A/G cg20290983 chr6:43655470 MRPS18A -0.98 -18.27 -0.75 8.33e-49 IgG glycosylation; CESC cis rs782590 0.643 rs5012561 chr2:55742032 G/C cg18811423 chr2:55921094 PNPT1 -0.55 -7.3 -0.41 3.27e-12 Metabolic syndrome; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg12975709 chr7:47317262 TNS3 -0.45 -6.13 -0.35 3.24e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs11711311 0.747 rs7638378 chr3:113343630 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.56 7.46 0.42 1.26e-12 IgG glycosylation; CESC cis rs3820928 0.904 rs2894623 chr2:227766112 T/C cg11843606 chr2:227700838 RHBDD1 -0.45 -5.87 -0.34 1.27e-8 Pulmonary function; CESC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg11235426 chr6:292522 DUSP22 -0.74 -9.99 -0.52 3.72e-20 Menopause (age at onset); CESC cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg25517755 chr10:38738941 LOC399744 -0.49 -6.3 -0.36 1.25e-9 Extrinsic epigenetic age acceleration; CESC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg18225595 chr11:63971243 STIP1 0.52 5.13 0.3 5.55e-7 Mean platelet volume; CESC cis rs4889855 0.556 rs4890040 chr17:78518408 G/A cg16591659 chr17:78472290 NA 0.36 5.86 0.34 1.38e-8 Fractional excretion of uric acid; CESC cis rs12586317 0.547 rs10134907 chr14:35499211 A/C cg05294307 chr14:35346193 BAZ1A -0.51 -5.4 -0.31 1.49e-7 Psoriasis; CESC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.45 -5.1 -0.3 6.56e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6540559 0.673 rs114467813 chr1:210017785 G/A cg25204440 chr1:209979598 IRF6 0.68 6.35 0.36 9.09e-10 Cleft lip with or without cleft palate; CESC cis rs34891900 0.507 rs12167771 chr22:18124332 G/A cg19898043 chr22:18121309 BCL2L13 0.62 7.38 0.41 2.02e-12 Sum neutrophil eosinophil counts; CESC cis rs8072100 1.000 rs4794048 chr17:45763073 A/C cg08085267 chr17:45401833 C17orf57 -0.43 -5.82 -0.34 1.67e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg15145296 chr3:125709740 NA -0.5 -5.26 -0.31 3.01e-7 Blood pressure (smoking interaction); CESC cis rs977987 0.843 rs12443904 chr16:75438770 C/T cg03315344 chr16:75512273 CHST6 0.4 5.83 0.34 1.57e-8 Dupuytren's disease; CESC cis rs6120849 0.754 rs6088667 chr20:33566722 A/C cg06115741 chr20:33292138 TP53INP2 0.51 5.13 0.3 5.5e-7 Protein C levels; CESC cis rs9399135 0.967 rs11756988 chr6:135347595 A/G cg22676075 chr6:135203613 NA 0.51 7.36 0.41 2.34e-12 Red blood cell count; CESC cis rs9649213 0.614 rs9640655 chr7:98017099 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.45 -6.11 -0.35 3.54e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs959260 1.000 rs4789193 chr17:73404796 A/T cg20590849 chr17:73267439 MIF4GD 0.55 6.18 0.35 2.43e-9 Systemic lupus erythematosus; CESC cis rs9457247 0.967 rs428805 chr6:167403132 C/A cg25258033 chr6:167368657 RNASET2 0.4 5.98 0.34 7.15e-9 Crohn's disease; CESC cis rs9584850 0.789 rs7988345 chr13:99117685 A/G cg20750642 chr13:99100586 FARP1 -0.39 -5.87 -0.34 1.3e-8 Neuroticism; CESC cis rs568617 1.000 rs693824 chr11:65654783 A/G cg19792802 chr11:65647270 CTSW 0.36 5.44 0.32 1.24e-7 Crohn's disease; CESC cis rs7267979 1.000 rs2424712 chr20:25416942 T/C cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.4e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7937682 0.883 rs486038 chr11:111465963 A/C cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC cis rs9660180 0.839 rs12040826 chr1:1705287 A/C cg23982607 chr1:1823379 GNB1 -0.73 -11.44 -0.57 6.94e-25 Body mass index; CESC cis rs7851660 0.839 rs7027221 chr9:100662379 T/C cg13688889 chr9:100608707 NA -0.62 -8.87 -0.48 1.11e-16 Strep throat; CESC cis rs13343954 0.518 rs2216594 chr19:33533258 G/A cg27124370 chr19:33622961 WDR88 0.5 6.63 0.38 1.88e-10 Colorectal cancer; CESC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg20151795 chr6:28129481 ZNF389 0.41 5.3 0.31 2.46e-7 Depression; CESC cis rs5758659 0.714 rs5751220 chr22:42516205 A/C cg19513890 chr22:42538836 CYP2D7P1 0.38 5.48 0.32 9.98e-8 Cognitive function; CESC cis rs798766 0.909 rs28521716 chr4:1745751 A/G cg10756475 chr4:1757242 NA 0.47 6.08 0.35 4.15e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs56104184 0.615 rs73061693 chr19:49399941 C/A cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs916888 0.738 rs199515 chr17:44856641 C/G cg15921436 chr17:44337874 NA -0.71 -8.29 -0.45 5.63e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.41 -0.32 1.43e-7 Self-reported allergy; CESC cis rs1847202 0.826 rs13063441 chr3:72952400 A/G cg10804678 chr3:72788309 NA -0.39 -5.04 -0.3 8.66e-7 Motion sickness; CESC cis rs644799 1.000 rs10831431 chr11:95510089 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.72 9.58 0.51 7.32e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6460942 0.591 rs62451465 chr7:12364585 A/G cg20607287 chr7:12443886 VWDE -0.59 -6.48 -0.37 4.4e-10 Coronary artery disease; CESC cis rs3008870 1.000 rs12132068 chr1:67451924 G/T cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -14.57 -0.67 9.76e-36 Lymphocyte percentage of white cells; CESC cis rs11997175 0.626 rs12155927 chr8:33789851 A/G ch.8.33884649F chr8:33765107 NA 0.49 5.78 0.33 2.07e-8 Body mass index; CESC cis rs7044106 0.791 rs12554440 chr9:123485333 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.76 11.24 0.57 3.25e-24 Hip circumference adjusted for BMI; CESC cis rs614226 0.935 rs7956998 chr12:120994932 G/A cg01236616 chr12:121019343 POP5 1.5 18.76 0.76 1.47e-50 Type 1 diabetes nephropathy; CESC cis rs9457247 1.000 rs408080 chr6:167392522 T/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.5 -0.46 1.43e-15 Crohn's disease; CESC cis rs9911578 1.000 rs2009948 chr17:56611920 A/C cg12560992 chr17:57184187 TRIM37 -0.93 -15.59 -0.69 2.43e-39 Intelligence (multi-trait analysis); CESC cis rs12142240 0.698 rs72677585 chr1:46812374 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.85 0.43 1.05e-13 Menopause (age at onset); CESC cis rs911555 0.673 rs7144271 chr14:103890674 A/G cg24130564 chr14:104152367 KLC1 -0.52 -7.1 -0.4 1.16e-11 Intelligence (multi-trait analysis); CESC cis rs4450798 0.793 rs9855726 chr3:13741475 T/A cg05589046 chr3:13742034 LOC285375 0.38 5.64 0.33 4.42e-8 Bipolar disorder with mood-incongruent psychosis; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg03758392 chr3:184870408 C3orf70 0.46 6.15 0.35 2.87e-9 Tetralogy of Fallot; CESC cis rs17039065 1.000 rs59671813 chr4:109393618 A/C cg16022748 chr4:109541635 LOC285456;RPL34 0.63 5.32 0.31 2.18e-7 Gut microbiome composition (summer); CESC cis rs9899728 0.539 rs77948815 chr17:73128192 C/T cg20590849 chr17:73267439 MIF4GD 0.96 5.81 0.34 1.78e-8 Alzheimer's disease or small vessel stroke; CESC cis rs7208859 0.623 rs3752021 chr17:29111043 G/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03046325 chr10:93558661 TNKS2 -0.45 -6.08 -0.35 4.1e-9 Ulcerative colitis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22792938 chr2:228337242 AGFG1 -0.5 -6.92 -0.39 3.33e-11 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12410370 chr1:43296526 ERMAP -0.58 -7.03 -0.4 1.75e-11 Gut microbiome composition (summer); CESC cis rs6032067 0.777 rs2868235 chr20:43794069 T/C cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs796364 0.806 rs203765 chr2:200903020 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.83 -7.71 -0.43 2.49e-13 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09067715 chr16:702600 WDR90 0.54 6.56 0.37 2.85e-10 Ulcerative colitis; CESC cis rs1983891 0.954 rs1886816 chr6:41544494 A/G cg20194872 chr6:41519635 FOXP4 0.55 7.76 0.43 1.88e-13 Prostate cancer; CESC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg18876405 chr7:65276391 NA 0.45 5.47 0.32 1.06e-7 Aortic root size; CESC cis rs2228479 0.718 rs11645376 chr16:89912281 G/C cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs929354 0.772 rs3802126 chr7:156970281 G/A cg05182265 chr7:156933206 UBE3C -0.5 -7.3 -0.41 3.28e-12 Body mass index; CESC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg11764359 chr7:65958608 NA 0.71 9.12 0.49 1.89e-17 Aortic root size; CESC cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.4 5.25 0.31 3.18e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs258892 0.841 rs266426 chr5:72131255 A/G cg21869765 chr5:72125136 TNPO1 0.44 5.62 0.33 4.78e-8 Small cell lung carcinoma; CESC cis rs4243830 0.850 rs10864612 chr1:6593830 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.97 -9.95 -0.52 4.99e-20 Body mass index; CESC cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.86 -0.39 4.91e-11 Hemoglobin concentration; CESC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg07648498 chr16:89883185 FANCA 0.5 6.1 0.35 3.78e-9 Vitiligo; CESC cis rs1707322 0.721 rs10430124 chr1:46221617 C/T cg03146154 chr1:46216737 IPP 0.79 11.09 0.56 9.79e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs832540 0.931 rs1466008 chr5:56213406 G/C cg14703610 chr5:56206110 C5orf35 0.53 7.03 0.4 1.78e-11 Coronary artery disease; CESC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Depression; CESC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 8.78 0.47 2.09e-16 Platelet count; CESC cis rs10504073 0.647 rs4348510 chr8:50016027 C/A cg00325661 chr8:49890786 NA 0.52 7.96 0.44 4.91e-14 Blood metabolite ratios; CESC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.61 7.77 0.43 1.7e-13 Menopause (age at onset); CESC cis rs7631605 0.905 rs9836891 chr3:37148882 C/G cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.06 -0.3 7.85e-7 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08841910 chr3:52321932 GLYCTK 0.57 6.03 0.35 5.38e-9 Gut microbiome composition (summer); CESC cis rs4808199 0.793 rs12459676 chr19:19425141 A/T cg03709012 chr19:19516395 GATAD2A 1.08 11.33 0.57 1.58e-24 Nonalcoholic fatty liver disease; CESC cis rs2204008 0.743 rs2132212 chr12:38039405 G/A cg26384229 chr12:38710491 ALG10B 0.52 7.31 0.41 3.2e-12 Bladder cancer; CESC cis rs4718428 0.705 rs12698547 chr7:66278258 T/C cg18252515 chr7:66147081 NA -0.49 -5.4 -0.31 1.49e-7 Corneal structure; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg27306913 chr1:231115237 TTC13;ARV1 -0.38 -6.07 -0.35 4.5e-9 Vertical cup-disc ratio; CESC cis rs3796352 1.000 rs11713290 chr3:52971579 G/A cg12962167 chr3:53033115 SFMBT1 0.6 5.09 0.3 6.95e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs2180341 0.782 rs4487601 chr6:127723521 A/G cg27446573 chr6:127587934 RNF146 0.8 11.46 0.58 5.73e-25 Breast cancer; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg15776560 chr3:25916362 NA -0.45 -6.28 -0.36 1.39e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1003719 0.762 rs2835598 chr21:38466669 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.5 0.46 1.44e-15 Eye color traits; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg14832358 chr2:45837811 SRBD1 0.5 6.37 0.36 8.17e-10 Tetralogy of Fallot; CESC cis rs796364 0.806 rs76568708 chr2:200929531 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.83 -7.6 -0.42 5.11e-13 Schizophrenia; CESC cis rs34779708 0.931 rs12242882 chr10:35347860 G/C cg04310649 chr10:35416472 CREM -0.53 -6.42 -0.37 6.1e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs703842 1.000 rs11172344 chr12:58193448 T/C cg00599273 chr12:58146742 CDK4 0.33 5.06 0.3 7.92e-7 Multiple sclerosis; CESC cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg10523679 chr1:76189770 ACADM -0.63 -6.43 -0.37 6e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg03351412 chr1:154909251 PMVK 0.57 7.08 0.4 1.27e-11 Prostate cancer; CESC cis rs68092024 0.704 rs793487 chr3:99495422 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.43 -6.8 -0.39 6.87e-11 Cleft lip with or without cleft palate; CESC cis rs35306767 0.909 rs12264390 chr10:959111 T/C cg20503657 chr10:835505 NA 0.67 7.46 0.42 1.25e-12 Eosinophil percentage of granulocytes; CESC trans rs239339 0.959 rs349388 chr1:4425712 C/T cg06451177 chr17:79412583 BAHCC1 0.52 6.11 0.35 3.63e-9 Obesity-related traits; CESC cis rs2880765 0.835 rs11638498 chr15:86023018 T/C cg19183879 chr15:85880815 NA -0.24 -5.13 -0.3 5.61e-7 Coronary artery disease; CESC cis rs561341 0.769 rs8074383 chr17:30178793 C/T cg12193833 chr17:30244370 NA 0.62 5.74 0.33 2.58e-8 Hip circumference adjusted for BMI; CESC cis rs17253792 0.822 rs17685102 chr14:56129214 A/G cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02384530 chr12:6961868 USP5;CDCA3 0.46 6.31 0.36 1.18e-9 Gut microbiota (bacterial taxa); CESC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg24399712 chr22:39784796 NA -0.81 -11.14 -0.56 6.95e-24 Intelligence (multi-trait analysis); CESC cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg01579765 chr21:45077557 HSF2BP -0.56 -9.3 -0.5 5.47e-18 Mean corpuscular volume; CESC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg01988459 chr11:68622903 NA -0.42 -5.9 -0.34 1.12e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23806609 chr7:66369525 NA -0.61 -7.18 -0.4 7.08e-12 Gut microbiome composition (summer); CESC cis rs2380220 0.872 rs2613528 chr6:95939437 C/G cg04719120 chr6:96025338 MANEA -0.55 -5.05 -0.3 8.27e-7 Behavioural disinhibition (generation interaction); CESC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg14664628 chr15:75095509 CSK -0.54 -7.22 -0.41 5.37e-12 Breast cancer; CESC cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg12923728 chr3:195709715 SDHAP1 -0.66 -8.66 -0.47 4.59e-16 Pancreatic cancer; CESC cis rs2251381 0.778 rs2245021 chr21:30546841 C/T cg24692254 chr21:30365293 RNF160 0.78 10.72 0.55 1.6400000000000001e-22 Selective IgA deficiency; CESC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg16132339 chr22:24313637 DDTL;DDT -0.37 -5.5 -0.32 9.06e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6952808 0.578 rs6949478 chr7:1841342 A/G cg22963979 chr7:1858916 MAD1L1 0.41 5.45 0.32 1.16e-7 Bipolar disorder and schizophrenia; CESC cis rs9303029 0.866 rs72857495 chr17:80412867 A/C cg04942655 chr17:80303572 NA -0.47 -5.07 -0.3 7.35e-7 Protein quantitative trait loci; CESC cis rs7246865 0.510 rs8103578 chr19:17171227 C/T cg16202187 chr19:17186497 HAUS8;MYO9B 0.48 6.26 0.36 1.56e-9 Reticulocyte fraction of red cells; CESC cis rs7851660 0.933 rs12341377 chr9:100610382 C/G cg13688889 chr9:100608707 NA -0.68 -10.64 -0.55 3.08e-22 Strep throat; CESC trans rs9929218 0.954 rs9923925 chr16:68819444 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.64 -8.6 -0.47 6.95e-16 Colorectal cancer; CESC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg19346786 chr7:2764209 NA -0.45 -6.44 -0.37 5.64e-10 Height; CESC cis rs4704187 0.687 rs2059159 chr5:74451178 G/C cg03227963 chr5:74354835 NA 0.3 5.5 0.32 8.75e-8 Response to amphetamines; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08688335 chr8:144635260 GSDMD -0.44 -6.38 -0.36 7.72e-10 Gambling; CESC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg07636037 chr3:49044803 WDR6 0.8 13.39 0.64 1.45e-31 Menarche (age at onset); CESC cis rs1215050 0.740 rs1214997 chr4:99041533 A/T cg17366294 chr4:99064904 C4orf37 0.41 5.34 0.31 1.95e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs7927592 0.956 rs11228277 chr11:68308324 G/A cg16797656 chr11:68205561 LRP5 0.43 6.33 0.36 1.03e-9 Total body bone mineral density; CESC cis rs2573652 0.722 rs12908133 chr15:100544405 G/A cg09918751 chr15:100517450 ADAMTS17 -0.29 -5.38 -0.31 1.63e-7 Height; CESC cis rs10754283 0.967 rs10801757 chr1:90103080 A/G cg21401794 chr1:90099060 LRRC8C 0.69 9.2 0.49 1.08e-17 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6142102 0.602 rs6141433 chr20:32548862 T/C cg08999081 chr20:33150536 PIGU 0.34 5.11 0.3 6.04e-7 Skin pigmentation; CESC cis rs854765 0.647 rs9303144 chr17:17977355 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.13 0.35 3.24e-9 Total body bone mineral density; CESC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg05025164 chr4:1340916 KIAA1530 0.52 7.28 0.41 3.88e-12 Longevity; CESC cis rs1023500 0.573 rs8135801 chr22:42475568 A/G cg15557168 chr22:42548783 NA 0.44 6.29 0.36 1.34e-9 Schizophrenia; CESC cis rs7589342 0.501 rs13429800 chr2:106441002 C/T cg16077055 chr2:106428750 NCK2 0.4 6.28 0.36 1.4e-9 Addiction; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg04025307 chr7:1156635 C7orf50 0.5 8.53 0.46 1.15e-15 Longevity;Endometriosis; CESC cis rs12893597 0.715 rs4624098 chr14:76826256 G/A cg20290672 chr14:76816747 NA -0.4 -5.6 -0.33 5.34e-8 Maximal oxygen uptake response; CESC trans rs1814175 0.616 rs4881723 chr11:49788566 G/T cg15704280 chr7:45808275 SEPT13 -0.99 -17.45 -0.73 6.41e-46 Height; CESC cis rs12135062 0.851 rs2651926 chr1:3101820 C/T cg00254258 chr1:3105189 PRDM16 -0.35 -5.19 -0.3 4.21e-7 Migraine; CESC cis rs7223966 1.000 rs8075521 chr17:61804954 C/T cg11494091 chr17:61959527 GH2 0.38 5.19 0.3 4.28e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.45 7.41 0.41 1.67e-12 Personality dimensions; CESC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg24675658 chr1:53192096 ZYG11B -0.57 -7.54 -0.42 7.73e-13 Monocyte count; CESC trans rs1814175 0.562 rs1794130 chr11:49903764 T/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs16866061 0.855 rs11687736 chr2:225405122 A/T cg12698349 chr2:225449008 CUL3 0.75 11.48 0.58 5.14e-25 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs10411936 0.962 rs10404046 chr19:16477255 G/C cg10248733 chr19:16607483 C19orf44;CALR3 0.54 6.38 0.37 7.69e-10 White blood cell count;Multiple sclerosis; CESC cis rs863345 0.604 rs1342948 chr1:158463294 A/G cg12129480 chr1:158549410 OR10X1 -0.35 -6.95 -0.39 2.86e-11 Pneumococcal bacteremia; CESC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg06028605 chr16:24865363 SLC5A11 0.57 8.01 0.44 3.63e-14 Intelligence (multi-trait analysis); CESC cis rs9902453 0.578 rs8073217 chr17:28164263 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.78 10.3 0.53 3.82e-21 Coffee consumption (cups per day); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg02677328 chr6:52267982 PAQR8 0.45 6.26 0.36 1.51e-9 Thyroid stimulating hormone; CESC cis rs3824867 0.920 rs7111873 chr11:47469439 A/G cg20307385 chr11:47447363 PSMC3 0.5 6.06 0.35 4.73e-9 Mean corpuscular hemoglobin; CESC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg23281280 chr6:28129359 ZNF389 0.59 8.16 0.45 1.34e-14 Parkinson's disease; CESC cis rs75804782 0.521 rs1123472 chr2:239414355 C/T cg18131467 chr2:239335373 ASB1 0.69 5.68 0.33 3.63e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs7666738 0.830 rs4292342 chr4:98959870 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.01 0.59 8.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs561341 0.505 rs548298 chr17:30297494 C/A cg00745463 chr17:30367425 LRRC37B -0.7 -7.02 -0.4 1.85e-11 Hip circumference adjusted for BMI; CESC cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg23711669 chr6:146136114 FBXO30 0.8 10.47 0.54 1.05e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs748404 0.697 rs567357 chr15:43571390 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.99 0.44 4.21e-14 Lung cancer; CESC cis rs959260 0.588 rs2385263 chr17:73321117 T/C cg20590849 chr17:73267439 MIF4GD -0.44 -5.2 -0.3 3.9e-7 Systemic lupus erythematosus; CESC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg26338869 chr17:61819248 STRADA 0.69 9.23 0.49 8.85e-18 Prudent dietary pattern; CESC cis rs6693567 0.586 rs875514 chr1:150484555 C/G cg09579323 chr1:150459698 TARS2 0.43 5.38 0.31 1.64e-7 Migraine; CESC cis rs208520 0.690 rs74707865 chr6:66717352 A/G cg07460842 chr6:66804631 NA 0.96 12.77 0.62 2e-29 Exhaled nitric oxide output; CESC cis rs3806843 0.868 rs2531342 chr5:140130612 C/T cg26395211 chr5:140044315 WDR55 0.4 5.16 0.3 4.86e-7 Depressive symptoms (multi-trait analysis); CESC trans rs60843830 1.000 rs7605824 chr2:280819 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.67 -8.37 -0.46 3.32e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs3780486 0.846 rs73484568 chr9:33132492 G/A cg20290983 chr6:43655470 MRPS18A 0.99 18.31 0.75 5.73e-49 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14482902 chr17:36714803 SRCIN1 0.54 6.0 0.35 6.44e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs9386141 chr6:146268623 T/A cg23711669 chr6:146136114 FBXO30 -0.81 -11.61 -0.58 1.87e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg04455712 chr21:45112962 RRP1B 0.39 5.71 0.33 3.1e-8 Mean corpuscular volume; CESC cis rs7267979 0.816 rs376742 chr20:25487417 A/C cg24626310 chr20:25276739 ABHD12;PYGB 0.77 14.48 0.66 2.17e-35 Liver enzyme levels (alkaline phosphatase); CESC cis rs4746818 1.000 rs9299502 chr10:70876934 C/T cg11621586 chr10:70884670 VPS26A 0.96 12.58 0.61 8.98e-29 Left atrial antero-posterior diameter; CESC cis rs2066819 1.000 rs117779516 chr12:56750872 G/C cg26714650 chr12:56694279 CS -1.4 -8.78 -0.47 2.1e-16 Psoriasis vulgaris; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12469361 chr1:982189 AGRN 0.51 6.72 0.38 1.11e-10 Fibrinogen levels; CESC cis rs3008870 1.000 rs3008855 chr1:67386204 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.94 -11.58 -0.58 2.28e-25 Lymphocyte percentage of white cells; CESC cis rs13064411 0.696 rs2087129 chr3:113142769 T/A cg18753928 chr3:113234510 CCDC52 -0.48 -5.75 -0.33 2.39e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs7208859 0.623 rs11657777 chr17:29091785 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg27170947 chr2:26402098 FAM59B -0.58 -6.92 -0.39 3.46e-11 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg05368731 chr17:41323189 NBR1 0.8 11.32 0.57 1.66e-24 Menopause (age at onset); CESC cis rs4642101 0.793 rs13320486 chr3:12822069 C/A cg24848339 chr3:12840334 CAND2 0.39 5.96 0.34 8.16e-9 QRS complex (12-leadsum); CESC cis rs7208859 0.623 rs56163556 chr17:29101868 G/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9911578 0.867 rs72628394 chr17:57121313 C/T cg12560992 chr17:57184187 TRIM37 -0.94 -15.74 -0.7 7.41e-40 Intelligence (multi-trait analysis); CESC cis rs921968 0.643 rs563268 chr2:219372912 T/G cg02176678 chr2:219576539 TTLL4 0.39 6.75 0.38 9.18e-11 Mean corpuscular hemoglobin concentration; CESC cis rs798766 0.723 rs3134865 chr4:1723279 T/C cg10756475 chr4:1757242 NA 0.45 6.2 0.36 2.15e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg12419862 chr22:24373484 LOC391322 -0.84 -11.92 -0.59 1.62e-26 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs4843747 0.671 rs72818576 chr16:88111019 C/G cg26811252 chr16:29126840 RRN3P2 0.69 9.65 0.51 4.31e-19 Menopause (age at onset); CESC cis rs524281 0.773 rs11227448 chr11:66048491 G/A cg14036092 chr11:66035641 RAB1B -0.54 -5.32 -0.31 2.23e-7 Electroencephalogram traits; CESC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg01171360 chr6:293285 DUSP22 -0.47 -6.28 -0.36 1.4e-9 Menopause (age at onset); CESC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.14 -0.3 5.26e-7 Bipolar disorder; CESC cis rs1018836 0.608 rs6992512 chr8:91477936 C/A cg16814680 chr8:91681699 NA -0.55 -7.57 -0.42 6.13e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs12618769 0.625 rs3769736 chr2:99089119 C/T cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg03467027 chr4:99064603 C4orf37 0.44 5.42 0.32 1.36e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4566357 1.000 rs7567796 chr2:227922109 T/A cg11843606 chr2:227700838 RHBDD1 -0.4 -5.16 -0.3 4.78e-7 Coronary artery disease; CESC cis rs2019216 0.502 rs1842113 chr17:21872137 G/A cg22648282 chr17:21454238 C17orf51 -0.41 -5.46 -0.32 1.09e-7 Pelvic organ prolapse; CESC cis rs10447248 0.674 rs6594320 chr5:107896326 C/T cg25075504 chr5:107899390 NA 0.36 5.5 0.32 9.09e-8 Adiponectin levels; CESC cis rs6912958 0.781 rs4334949 chr6:88290150 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.58 -0.37 2.55e-10 Monocyte percentage of white cells; CESC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg00149659 chr3:10157352 C3orf10 0.72 8.87 0.48 1.09e-16 Alzheimer's disease; CESC cis rs6500395 1.000 rs7190106 chr16:48705542 C/T cg04672837 chr16:48644449 N4BP1 0.52 6.68 0.38 1.39e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9287719 0.967 rs1541574 chr2:10773508 A/T cg02196655 chr2:10830764 NOL10 -0.36 -5.36 -0.31 1.79e-7 Prostate cancer; CESC cis rs936229 0.654 rs762551 chr15:75041917 C/A cg14664628 chr15:75095509 CSK -0.79 -10.82 -0.55 7.49e-23 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs1005224 0.654 rs8005753 chr14:76136086 A/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.44 -6.01 -0.35 6.18e-9 Large artery stroke; CESC cis rs2228479 0.850 rs74251570 chr16:89910068 C/A cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.24 0.41 4.89e-12 Height; CESC cis rs7818688 1.000 rs34700722 chr8:96021876 A/G cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.19e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs593982 1.000 rs650619 chr11:65506483 G/A cg08755490 chr11:65554678 OVOL1 1.32 19.72 0.77 6.73e-54 Atopic dermatitis; CESC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.61 8.06 0.44 2.6e-14 Menopause (age at onset); CESC cis rs7762018 1.000 rs7747645 chr6:170070291 G/C cg13891659 chr6:170190454 C6orf122;C6orf208 0.53 5.41 0.32 1.43e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg24060327 chr5:131705240 SLC22A5 -0.77 -10.88 -0.56 4.91e-23 Breast cancer; CESC cis rs4253772 0.637 rs8135997 chr22:46651366 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.18 0.45 1.16e-14 LDL cholesterol;Cholesterol, total; CESC cis rs6964587 1.000 rs6960867 chr7:91712698 A/G cg01689657 chr7:91764605 CYP51A1 0.29 5.16 0.3 4.88e-7 Breast cancer; CESC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.62 8.65 0.47 4.93e-16 Bipolar disorder; CESC cis rs11122272 0.735 rs2749708 chr1:231529610 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs3733585 0.579 rs4235356 chr4:10123106 G/C cg02734326 chr4:10020555 SLC2A9 -0.37 -5.15 -0.3 5.14e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.4 0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10870270 0.784 rs10430614 chr10:133748640 C/T cg17892150 chr10:133769511 PPP2R2D 0.78 11.4 0.57 9.42e-25 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs854765 0.587 rs4077828 chr17:17833644 A/T cg16928487 chr17:17741425 SREBF1 -0.57 -9.74 -0.51 2.33e-19 Total body bone mineral density; CESC cis rs7246865 0.859 rs7252102 chr19:17197012 A/G cg19418318 chr19:17219073 MYO9B 0.35 5.87 0.34 1.33e-8 Reticulocyte fraction of red cells; CESC cis rs6496667 0.558 rs10459677 chr15:91042399 A/C cg10434728 chr15:90938212 IQGAP1 -0.34 -5.76 -0.33 2.29e-8 Rheumatoid arthritis; CESC cis rs9926296 0.533 rs12102290 chr16:89812617 C/T cg03388025 chr16:89894329 SPIRE2 0.39 7.42 0.41 1.63e-12 Vitiligo; CESC cis rs2929278 0.617 rs663214 chr15:44113782 T/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.47 -7.27 -0.41 4.03e-12 Schizophrenia; CESC cis rs1003719 0.715 rs2835647 chr21:38546773 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.06 -0.44 2.72e-14 Eye color traits; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11662638 chr2:45878864 PRKCE -0.51 -6.8 -0.39 6.78e-11 Ulcerative colitis; CESC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg07952391 chr2:88470173 THNSL2 -0.54 -8.14 -0.45 1.59e-14 Response to metformin (IC50); CESC cis rs7666738 0.606 rs10006414 chr4:99101401 T/C cg17366294 chr4:99064904 C4orf37 0.46 5.94 0.34 8.85e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7191439 0.790 rs2306046 chr16:88781419 A/G cg27087555 chr16:88793112 FAM38A -1.17 -10.08 -0.53 1.98e-20 Plateletcrit; CESC cis rs7586879 0.521 rs1865689 chr2:25108197 C/T cg01884057 chr2:25150051 NA -0.33 -6.19 -0.36 2.3e-9 Body mass index; CESC cis rs7129220 0.512 rs12279871 chr11:10228196 G/A cg01453529 chr11:10209919 SBF2 -0.46 -5.67 -0.33 3.77e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg02475777 chr4:1388615 CRIPAK -0.47 -5.98 -0.34 7.11e-9 Obesity-related traits; CESC cis rs698833 0.741 rs2340808 chr2:44511861 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.56 6.91 0.39 3.68e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg04234412 chr22:24373322 LOC391322 0.65 9.54 0.51 1e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs926938 0.527 rs2335954 chr1:115534151 C/T cg12756093 chr1:115239321 AMPD1 -0.47 -6.45 -0.37 5.14e-10 Autism; CESC cis rs4268898 0.636 rs72787383 chr2:24583861 G/A cg20701182 chr2:24300061 SF3B14 0.66 6.97 0.39 2.47e-11 Asthma; CESC cis rs7917772 0.560 rs729023 chr10:104341887 A/G ch.10.2196322F chr10:104248062 ACTR1A -0.4 -5.03 -0.3 8.96e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs3020736 0.500 rs11090076 chr22:42514190 T/C cg04733989 chr22:42467013 NAGA -0.78 -11.9 -0.59 1.87e-26 Autism spectrum disorder or schizophrenia; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg03407747 chr17:6899364 ALOX12 0.49 8.6 0.47 6.86e-16 Tonsillectomy; CESC trans rs2571521 0.887 rs9298879 chr9:26097224 A/C ch.15.23688912F chr15:26137819 NA 0.78 6.1 0.35 3.75e-9 Pursuit maintenance gain in psychotic disorders; CESC cis rs2439831 1.000 rs689754 chr15:43775895 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.83 11.48 0.58 5.16e-25 Lung cancer in ever smokers; CESC cis rs10200159 1.000 rs9309267 chr2:55850333 A/G cg13617705 chr2:55845095 SMEK2 -0.72 -5.18 -0.3 4.41e-7 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03051979 chr16:58283909 CCDC113 0.58 6.84 0.39 5.37e-11 Gut microbiome composition (summer); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg23743186 chr22:39152048 UNC84B 0.55 6.57 0.37 2.58e-10 Psoriatic arthritis; CESC cis rs6547741 1.000 rs4665381 chr2:27757150 A/C cg21248554 chr2:27665150 KRTCAP3 0.25 5.15 0.3 5.01e-7 Oral cavity cancer; CESC cis rs116095464 0.558 rs9688136 chr5:229348 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.65 -0.47 5.2e-16 Breast cancer; CESC cis rs10870270 0.917 rs9971362 chr10:133790150 T/C cg17892150 chr10:133769511 PPP2R2D -0.84 -12.03 -0.59 6.71e-27 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg25019033 chr10:957182 NA 0.55 7.98 0.44 4.5e-14 Eosinophil percentage of granulocytes; CESC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg16545954 chr1:2118288 C1orf86 -0.37 -7.04 -0.4 1.65e-11 Height; CESC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg04025307 chr7:1156635 C7orf50 -0.56 -9.95 -0.52 5.16e-20 Longevity;Endometriosis; CESC cis rs10078 0.571 rs890977 chr5:476910 T/C cg16584290 chr5:462447 EXOC3 0.47 5.1 0.3 6.39e-7 Fat distribution (HIV); CESC cis rs7216064 0.953 rs11079705 chr17:65835452 A/T cg12091567 chr17:66097778 LOC651250 -0.86 -8.83 -0.48 1.49e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10102242 chr16:4422216 VASN;CORO7 0.5 6.26 0.36 1.5e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9488822 0.676 rs868943 chr6:116337503 G/A cg05304507 chr6:116381966 FRK 0.25 6.58 0.37 2.49e-10 Cholesterol, total;LDL cholesterol; CESC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 10.52 0.54 7.52e-22 Platelet count; CESC cis rs1322639 0.614 rs4708414 chr6:169574144 C/G cg04662567 chr6:169592167 NA -0.38 -5.46 -0.32 1.08e-7 Pulse pressure; CESC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg01416388 chr22:39784598 NA -0.59 -7.23 -0.41 5.21e-12 Intelligence (multi-trait analysis); CESC cis rs12893668 0.697 rs67899457 chr14:104060066 A/T cg24130564 chr14:104152367 KLC1 -0.48 -6.09 -0.35 4.01e-9 Reticulocyte count; CESC cis rs265548 0.538 rs36688 chr19:17911212 A/C cg16024904 chr19:17905718 B3GNT3 0.43 5.72 0.33 2.8e-8 Tumor biomarkers; CESC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg08888203 chr3:10149979 C3orf24 0.49 6.33 0.36 1.05e-9 Alzheimer's disease; CESC cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.44 0.32 1.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.55 0.37 2.91e-10 Prudent dietary pattern; CESC cis rs11252926 0.800 rs2209625 chr10:747115 A/C cg08603382 chr10:743973 NA -0.61 -8.12 -0.45 1.74e-14 Psychosis in Alzheimer's disease; CESC cis rs7647973 1.000 rs7647973 chr3:49510931 G/A cg07636037 chr3:49044803 WDR6 -0.7 -9.53 -0.51 1.06e-18 Menarche (age at onset); CESC cis rs3820928 0.874 rs7576081 chr2:227843634 C/G cg11843606 chr2:227700838 RHBDD1 -0.44 -5.76 -0.33 2.35e-8 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22031650 chr11:111957494 SDHD;TIMM8B 0.58 6.67 0.38 1.51e-10 Gut microbiome composition (summer); CESC cis rs634534 0.563 rs470192 chr11:65724291 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.74 10.78 0.55 1.01e-22 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs17407555 0.821 rs4473652 chr4:10141617 G/C cg00071950 chr4:10020882 SLC2A9 -0.58 -5.29 -0.31 2.53e-7 Schizophrenia (age at onset); CESC cis rs2228479 0.541 rs12918575 chr16:89811151 A/G cg27121462 chr16:89883253 FANCA 0.63 5.51 0.32 8.36e-8 Skin colour saturation; CESC cis rs1707322 0.752 rs12027622 chr1:46130252 A/C cg05343316 chr1:45956843 TESK2 0.51 6.24 0.36 1.7e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2832191 0.740 rs2832177 chr21:30478353 G/A cg08807101 chr21:30365312 RNF160 -0.92 -13.86 -0.65 3.09e-33 Dental caries; CESC cis rs7246657 0.943 rs1015849 chr19:37946180 G/A cg23950597 chr19:37808831 NA -0.61 -6.23 -0.36 1.85e-9 Coronary artery calcification; CESC cis rs804280 0.662 rs11784764 chr8:11610874 C/T cg26752888 chr8:11627280 NEIL2 0.68 6.18 0.36 2.38e-9 Myopia (pathological); CESC cis rs698833 0.532 rs2616444 chr2:44605518 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.44 0.32 1.18e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.48e-10 Depression; CESC cis rs644799 0.965 rs2950522 chr11:95524719 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.3 0.5 5.52e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6429082 0.715 rs2131924 chr1:235580928 G/A cg26050004 chr1:235667680 B3GALNT2 -0.54 -6.75 -0.38 9.44e-11 Adiposity; CESC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg21782813 chr7:2030301 MAD1L1 0.51 7.28 0.41 3.86e-12 Bipolar disorder and schizophrenia; CESC cis rs4664304 0.629 rs1606117 chr2:160850716 C/T cg03641300 chr2:160917029 PLA2R1 -0.43 -5.8 -0.34 1.86e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs4953318 0.619 rs13406901 chr2:46363066 T/G cg12428440 chr2:46370979 PRKCE 0.49 6.48 0.37 4.56e-10 Red blood cell count;Hematocrit;Red blood cell traits; CESC trans rs17307778 0.908 rs10742085 chr11:25358050 A/T cg22888484 chr20:37075185 SNHG11 -0.63 -6.07 -0.35 4.42e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg11494091 chr17:61959527 GH2 0.72 12.44 0.61 2.76e-28 Prudent dietary pattern; CESC cis rs13102973 0.965 rs4535381 chr4:135861313 A/T cg14419869 chr4:135874104 NA 0.34 5.24 0.31 3.3e-7 Subjective well-being; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05602987 chr16:28834702 ATXN2L -0.47 -6.36 -0.36 8.59e-10 Ulcerative colitis; CESC cis rs4955124 0.730 rs12639105 chr3:32047336 C/T cg05935571 chr3:32023257 ZNF860;OSBPL10 0.8 5.88 0.34 1.2e-8 Schizophrenia; CESC cis rs6087990 0.806 rs910084 chr20:31379665 C/T cg13636640 chr20:31349939 DNMT3B 0.76 11.63 0.58 1.55e-25 Ulcerative colitis; CESC trans rs62103177 0.564 rs11874805 chr18:77697110 T/C cg05926928 chr17:57297772 GDPD1 0.79 7.47 0.42 1.14e-12 Opioid sensitivity; CESC cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg26769984 chr7:1090371 C7orf50 0.67 7.58 0.42 5.87e-13 Bronchopulmonary dysplasia; CESC cis rs7512552 0.839 rs1694362 chr1:150366963 T/A cg15654264 chr1:150340011 RPRD2 0.39 5.17 0.3 4.68e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs2294693 0.947 rs4714417 chr6:40987782 A/G cg14418226 chr6:40996092 UNC5CL 0.53 6.51 0.37 3.83e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs6582630 0.555 rs7133706 chr12:38475465 G/A cg26384229 chr12:38710491 ALG10B -0.65 -9.74 -0.51 2.31e-19 Drug-induced liver injury (flucloxacillin); CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg18538332 chr22:24372958 LOC391322 -0.75 -11.24 -0.57 3.27e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs763121 0.853 rs6001182 chr22:39047443 A/G cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg07507251 chr3:52567010 NT5DC2 0.4 7.06 0.4 1.49e-11 Bipolar disorder; CESC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.53 -0.37 3.29e-10 Bipolar disorder; CESC cis rs793571 0.523 rs12439457 chr15:58982390 T/C cg05156742 chr15:59063176 FAM63B 0.58 7.79 0.43 1.53e-13 Schizophrenia; CESC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg06873352 chr17:61820015 STRADA 0.73 13.12 0.63 1.2e-30 Prudent dietary pattern; CESC cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg13072238 chr3:49761600 GMPPB -0.51 -6.14 -0.35 3.03e-9 Menarche (age at onset); CESC cis rs9486715 1.000 rs9398148 chr6:97063555 A/G cg18709589 chr6:96969512 KIAA0776 -0.44 -6.2 -0.36 2.17e-9 Headache; CESC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg21724239 chr8:58056113 NA 0.56 5.97 0.34 7.66e-9 Developmental language disorder (linguistic errors); CESC cis rs920590 0.684 rs59259846 chr8:19669468 C/G cg03894339 chr8:19674705 INTS10 0.68 7.77 0.43 1.73e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs1468333 0.514 rs10515498 chr5:137586330 C/T cg27119451 chr5:137514611 BRD8;KIF20A 0.48 5.1 0.3 6.58e-7 Resting heart rate; CESC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg25517755 chr10:38738941 LOC399744 -0.45 -5.84 -0.34 1.55e-8 Extrinsic epigenetic age acceleration; CESC cis rs30380 0.632 rs26491 chr5:96134113 A/G cg16492584 chr5:96139282 ERAP1 -0.49 -6.65 -0.38 1.7e-10 Cerebrospinal fluid biomarker levels; CESC cis rs634534 0.532 rs12794370 chr11:65770413 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 10.62 0.55 3.4e-22 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs9733 0.519 rs1134067 chr1:150721175 G/T cg09365446 chr1:150670422 GOLPH3L 0.4 5.29 0.31 2.54e-7 Tonsillectomy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20832448 chr3:36418645 NA -0.42 -6.24 -0.36 1.76e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7044106 0.708 rs10984992 chr9:123473416 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.07 0.35 4.38e-9 Hip circumference adjusted for BMI; CESC cis rs12410462 0.581 rs77430808 chr1:227540880 C/T cg04117972 chr1:227635322 NA 0.64 5.38 0.31 1.66e-7 Major depressive disorder; CESC cis rs6938 0.618 rs11072514 chr15:75221865 T/A cg09165964 chr15:75287851 SCAMP5 0.47 6.32 0.36 1.12e-9 Breast cancer; CESC cis rs9303401 0.614 rs3087762 chr17:56568680 C/T cg25039879 chr17:56429692 SUPT4H1 0.51 5.13 0.3 5.51e-7 Cognitive test performance; CESC cis rs753778 0.602 rs9792 chr8:142205237 C/T cg23750338 chr8:142222470 SLC45A4 -0.35 -5.05 -0.3 8.05e-7 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs9549367 1.000 rs9549367 chr13:113911532 C/G cg00898013 chr13:113819073 PROZ -0.5 -7.15 -0.4 8.55e-12 Platelet distribution width; CESC cis rs11792861 0.926 rs72607173 chr9:111879398 T/G cg13535736 chr9:111863775 C9orf5 -0.49 -6.6 -0.38 2.27e-10 Menarche (age at onset); CESC trans rs2877832 0.778 rs73603734 chr14:27822362 A/G cg13449535 chr1:1101348 MIR200B 0.55 6.65 0.38 1.67e-10 Diabetes related insulin traits; CESC cis rs1707322 0.686 rs2991979 chr1:46055858 A/G cg05343316 chr1:45956843 TESK2 -0.53 -6.5 -0.37 3.87e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs72781680 0.800 rs72780112 chr2:23991182 C/T cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg21918786 chr6:109611834 NA -0.42 -6.34 -0.36 9.81e-10 Reticulocyte fraction of red cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13876163 chr1:45140495 C1orf228;TMEM53 -0.44 -6.3 -0.36 1.23e-9 Gambling; CESC cis rs763121 0.889 rs4820335 chr22:38935927 C/G cg06022373 chr22:39101656 GTPBP1 -0.74 -11.12 -0.56 7.88e-24 Menopause (age at onset); CESC cis rs4664308 1.000 rs4665147 chr2:160917062 A/G cg03641300 chr2:160917029 PLA2R1 -0.67 -10.08 -0.53 1.88e-20 Idiopathic membranous nephropathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15264303 chr12:7013902 LRRC23 -0.68 -8.13 -0.45 1.66e-14 Gut microbiome composition (summer); CESC cis rs9611565 0.694 rs202616 chr22:41822221 C/G cg03806693 chr22:41940476 POLR3H 1.2 14.5 0.67 1.86e-35 Vitiligo; CESC cis rs61931739 0.817 rs10772143 chr12:34230651 T/G cg19457237 chr12:34500585 NA -0.4 -5.53 -0.32 7.72e-8 Morning vs. evening chronotype; CESC cis rs3733585 0.605 rs56178126 chr4:10123581 C/T cg00071950 chr4:10020882 SLC2A9 -0.65 -9.75 -0.51 2.23e-19 Cleft plate (environmental tobacco smoke interaction); CESC trans rs10242455 0.702 rs112475236 chr7:99044679 A/G cg09045935 chr12:6379348 NA 0.92 7.57 0.42 6.02e-13 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05611199 chr16:88637223 ZC3H18 0.66 8.03 0.44 3.19e-14 Gut microbiome composition (summer); CESC trans rs4927850 0.881 rs7630489 chr3:195753401 T/C cg16724585 chr3:197361211 NA -0.56 -7.2 -0.4 6.32e-12 Pancreatic cancer; CESC cis rs1218582 0.600 rs72702224 chr1:154911689 G/A cg03351412 chr1:154909251 PMVK 0.52 6.36 0.36 8.93e-10 Prostate cancer; CESC cis rs6570726 0.935 rs380433 chr6:145859601 A/T cg05347473 chr6:146136440 FBXO30 0.48 6.44 0.37 5.7e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6088590 1.000 rs55753039 chr20:33394940 C/T cg08999081 chr20:33150536 PIGU 0.6 8.81 0.48 1.63e-16 Coronary artery disease; CESC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.79 10.29 0.53 4.01e-21 Height; CESC cis rs4730250 0.707 rs10253291 chr7:106786550 C/A cg02696742 chr7:106810147 HBP1 0.54 5.18 0.3 4.44e-7 Osteoarthritis; CESC cis rs1707322 1.000 rs34694458 chr1:46332696 G/A cg05343316 chr1:45956843 TESK2 0.42 5.18 0.3 4.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg25405998 chr7:65216604 CCT6P1 -0.5 -5.28 -0.31 2.64e-7 Aortic root size; CESC cis rs9457247 1.000 rs393727 chr6:167398632 T/A cg25258033 chr6:167368657 RNASET2 0.4 6.1 0.35 3.81e-9 Crohn's disease; CESC cis rs9790314 0.818 rs6797066 chr3:161008725 T/A cg03342759 chr3:160939853 NMD3 -0.51 -7.26 -0.41 4.27e-12 Morning vs. evening chronotype; CESC cis rs2839186 1.000 rs2839186 chr21:47690068 C/T cg10351095 chr21:47802916 PCNT -0.53 -7.32 -0.41 3.06e-12 Testicular germ cell tumor; CESC cis rs7216064 1.000 rs12451721 chr17:65939075 G/A cg12091567 chr17:66097778 LOC651250 -0.8 -8.08 -0.44 2.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs290268 0.585 rs290992 chr9:93561309 C/T cg02608019 chr9:93564028 SYK -0.45 -6.05 -0.35 5.01e-9 Platelet count; CESC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg26338869 chr17:61819248 STRADA 0.65 8.37 0.46 3.42e-15 Prudent dietary pattern; CESC cis rs1568889 1.000 rs7937117 chr11:28370038 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.86 0.55 5.8e-23 Bipolar disorder; CESC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02336323 chr4:54931210 CHIC2 -0.53 -6.37 -0.36 8.29e-10 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg16606324 chr3:10149918 C3orf24 0.41 5.03 0.3 8.88e-7 Alzheimer's disease; CESC trans rs7131987 0.903 rs2194518 chr12:29419460 C/T cg13198235 chr1:193028919 TROVE2;UCHL5 0.51 6.04 0.35 5.08e-9 QT interval; CESC cis rs12701220 0.901 rs12701713 chr7:1090505 G/A cg26769984 chr7:1090371 C7orf50 0.66 7.74 0.43 2.16e-13 Bronchopulmonary dysplasia; CESC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg22105103 chr4:187893119 NA 0.51 7.61 0.42 4.66e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7940866 0.903 rs2324316 chr11:130872353 G/T cg12179176 chr11:130786555 SNX19 0.67 9.62 0.51 5.64e-19 Schizophrenia; CESC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg25072359 chr17:41440525 NA 0.5 6.77 0.38 8.41e-11 Menopause (age at onset); CESC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg02269571 chr22:50332266 NA -0.45 -6.04 -0.35 5.22e-9 Schizophrenia; CESC cis rs854765 0.647 rs6826 chr17:18011140 C/T cg04398451 chr17:18023971 MYO15A -0.8 -11.92 -0.59 1.64e-26 Total body bone mineral density; CESC cis rs76533333 0.646 rs71446623 chr13:113374732 C/T cg08557188 chr13:113420371 ATP11A -0.72 -5.04 -0.3 8.54e-7 Red cell distribution width; CESC cis rs10979 0.931 rs12191837 chr6:143898200 T/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.19 -0.49 1.17e-17 Hypospadias; CESC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg00908189 chr16:619842 PIGQ 0.61 8.5 0.46 1.37e-15 Height; CESC cis rs72829446 0.556 rs10048219 chr17:7403792 C/T cg02795151 chr17:7402630 POLR2A 0.6 5.86 0.34 1.39e-8 Androgen levels; CESC cis rs5743618 0.537 rs10019951 chr4:38765584 A/G cg02016764 chr4:38805732 TLR1 -0.34 -5.21 -0.3 3.84e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs9486719 1.000 rs11153058 chr6:97012746 C/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.69 -0.33 3.43e-8 Migraine;Coronary artery disease; CESC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -7.41 -0.41 1.67e-12 Developmental language disorder (linguistic errors); CESC cis rs739401 0.611 rs391188 chr11:3047634 G/A cg25174290 chr11:3078921 CARS 0.55 7.9 0.44 7.59e-14 Longevity; CESC cis rs4689592 0.554 rs66925245 chr4:7071999 C/T cg06697600 chr4:7070879 GRPEL1 0.51 6.49 0.37 4.15e-10 Monocyte percentage of white cells; CESC cis rs863345 0.604 rs6663277 chr1:158495001 A/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.75e-11 Pneumococcal bacteremia; CESC cis rs1642645 0.831 rs7541929 chr1:42479393 G/A cg16685388 chr1:42384056 HIVEP3 0.38 5.68 0.33 3.57e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs2243480 1.000 rs2460422 chr7:65601505 C/T cg12463550 chr7:65579703 CRCP 0.74 5.75 0.33 2.4e-8 Diabetic kidney disease; CESC cis rs12477438 0.520 rs2632283 chr2:99776000 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.84 0.62 1.16e-29 Chronic sinus infection; CESC cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg25019033 chr10:957182 NA -0.61 -6.8 -0.39 6.93e-11 Eosinophil percentage of granulocytes; CESC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg04944784 chr2:26401820 FAM59B 0.95 9.94 0.52 5.28e-20 Gut microbiome composition (summer); CESC cis rs11250464 0.755 rs11250468 chr10:1410060 A/G cg26394196 chr10:1453818 ADARB2 -0.42 -5.66 -0.33 3.91e-8 Radiation response; CESC cis rs9399135 0.967 rs7763836 chr6:135362378 T/C cg24558204 chr6:135376177 HBS1L 0.5 6.88 0.39 4.35e-11 Red blood cell count; CESC trans rs9858542 0.953 rs11922013 chr3:49458355 G/C cg21659725 chr3:3221576 CRBN -0.55 -6.52 -0.37 3.63e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6598955 0.724 rs6656716 chr1:26563105 G/A cg00852783 chr1:26633632 UBXN11 0.44 6.48 0.37 4.56e-10 Obesity-related traits; CESC cis rs11078597 0.767 rs874424 chr17:1640034 G/A cg18436246 chr17:1640651 WDR81 0.62 7.54 0.42 7.44e-13 Serum albumin level; CESC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg06713675 chr4:122721982 EXOSC9 -0.51 -6.9 -0.39 3.9e-11 Type 2 diabetes; CESC cis rs12887734 0.546 rs12885509 chr14:104273325 T/C cg01849466 chr14:104193079 ZFYVE21 -0.45 -5.69 -0.33 3.3e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs1122900 1.000 rs1122900 chr5:36689181 A/C cg24186104 chr5:36689192 NA -0.45 -6.88 -0.39 4.29e-11 Aggressive periodontitis; CESC cis rs977987 0.806 rs2161684 chr16:75479153 T/C cg03315344 chr16:75512273 CHST6 0.43 6.15 0.35 2.85e-9 Dupuytren's disease; CESC cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.23e-9 Extrinsic epigenetic age acceleration; CESC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg23758822 chr17:41437982 NA 1.01 15.28 0.68 3.1e-38 Menopause (age at onset); CESC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg13628971 chr7:2884303 GNA12 0.64 9.03 0.49 3.6e-17 Height; CESC cis rs72945132 0.882 rs66989619 chr11:70202127 G/C cg14191688 chr11:70257035 CTTN 0.41 5.12 0.3 6.02e-7 Coronary artery disease; CESC cis rs2070677 1.000 rs1410897 chr10:135349537 G/A cg20169779 chr10:135381914 SYCE1 0.7 8.34 0.46 4.08e-15 Gout; CESC cis rs4925386 0.959 rs4925385 chr20:60920624 A/G cg24112000 chr20:60950667 NA 0.48 7.14 0.4 8.98e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs909674 0.690 rs5750825 chr22:39831278 A/G cg01416388 chr22:39784598 NA -0.58 -7.35 -0.41 2.51e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg03609598 chr5:56110824 MAP3K1 -0.51 -5.31 -0.31 2.33e-7 Initial pursuit acceleration; CESC cis rs698833 0.926 rs1067339 chr2:44624448 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 6.51 0.37 3.71e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03047724 chr7:139477895 TBXAS1;HIPK2 0.58 6.56 0.37 2.81e-10 Gut microbiome composition (summer); CESC trans rs78579285 0.545 rs79311053 chr16:88785206 C/T cg15076811 chr1:11001038 NA 0.72 6.2 0.36 2.13e-9 Joint mobility (Beighton score); CESC cis rs12765878 0.967 rs10883948 chr10:105667552 G/T cg24587175 chr10:105670608 OBFC1 0.33 5.36 0.31 1.84e-7 Coronary artery disease; CESC cis rs870825 0.616 rs745656 chr4:185637523 C/T cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs2479106 0.963 rs1778900 chr9:126549420 T/G cg16191174 chr9:126692580 DENND1A 0.51 6.95 0.39 2.83e-11 Polycystic ovary syndrome; CESC cis rs1969363 0.509 rs8189633 chr12:38065155 C/G cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Morning vs. evening chronotype; CESC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg11890956 chr21:40555474 PSMG1 -1.16 -20.43 -0.78 2.39e-56 Cognitive function; CESC trans rs3780486 0.846 rs7036812 chr9:33143822 T/C cg20290983 chr6:43655470 MRPS18A 0.97 17.46 0.73 5.92e-46 IgG glycosylation; CESC cis rs11190604 1.000 rs1080698 chr10:102295114 G/T cg07080220 chr10:102295463 HIF1AN 0.67 6.18 0.36 2.38e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg05283184 chr6:79620031 NA -0.42 -6.48 -0.37 4.35e-10 Intelligence (multi-trait analysis); CESC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg27266027 chr21:40555129 PSMG1 0.47 5.42 0.32 1.32e-7 Cognitive function; CESC cis rs8114671 0.836 rs6058154 chr20:33585834 C/T cg06115741 chr20:33292138 TP53INP2 -0.48 -5.8 -0.34 1.93e-8 Height; CESC cis rs9287719 0.935 rs10803723 chr2:10722877 C/T cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.35e-8 Prostate cancer; CESC cis rs35146811 0.844 rs4424195 chr7:99642745 A/G cg22906224 chr7:99728672 NA 0.48 5.72 0.33 2.82e-8 Coronary artery disease; CESC cis rs2839186 0.872 rs13052233 chr21:47707284 G/T cg10351095 chr21:47802916 PCNT -0.51 -6.9 -0.39 3.72e-11 Testicular germ cell tumor; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17282910 chr5:89825494 LYSMD3 0.53 7.34 0.41 2.57e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg07395648 chr5:131743802 NA 0.47 6.27 0.36 1.42e-9 Blood metabolite levels; CESC cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg13628971 chr7:2884303 GNA12 -0.6 -7.48 -0.42 1.11e-12 Height; CESC cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg03467027 chr4:99064603 C4orf37 -0.43 -5.32 -0.31 2.23e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 0.618 rs13129002 chr4:17567513 A/G cg27347728 chr4:17578864 LAP3 0.49 5.88 0.34 1.23e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg08470875 chr2:26401718 FAM59B -0.62 -6.69 -0.38 1.35e-10 Gut microbiome composition (summer); CESC cis rs7520050 0.966 rs12405451 chr1:46384326 T/A cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.67e-9 Red blood cell count;Reticulocyte count; CESC cis rs8044995 0.563 rs56220628 chr16:68384837 G/A cg26727032 chr16:67993705 SLC12A4 -0.5 -5.2 -0.3 4.07e-7 Schizophrenia; CESC cis rs9300255 0.722 rs34997336 chr12:123829116 G/A cg00376283 chr12:123451042 ABCB9 -0.58 -6.75 -0.38 9.12e-11 Neutrophil percentage of white cells; CESC cis rs11958404 0.932 rs72816581 chr5:157432591 T/A cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs6541297 0.703 rs2748115 chr1:230314291 A/G cg20703242 chr1:230279135 GALNT2 -0.43 -5.6 -0.33 5.46e-8 Coronary artery disease; CESC cis rs6088590 1.000 rs6087623 chr20:33317662 C/G cg06115741 chr20:33292138 TP53INP2 0.58 7.24 0.41 4.8e-12 Coronary artery disease; CESC cis rs35146811 0.807 rs10228764 chr7:99608029 A/G cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.46 5.71 0.33 3.04e-8 Coronary artery disease; CESC cis rs7208859 0.623 rs76633166 chr17:29113365 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11098499 0.779 rs72918579 chr4:120333222 G/C cg25214090 chr10:38739885 LOC399744 0.71 9.83 0.52 1.2e-19 Corneal astigmatism; CESC cis rs7833790 0.676 rs7834555 chr8:82697625 A/G cg17211192 chr8:82754475 SNX16 -0.58 -7.62 -0.42 4.64e-13 Diastolic blood pressure; CESC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg21984481 chr17:79567631 NPLOC4 -0.35 -5.52 -0.32 8.26e-8 Eye color traits; CESC cis rs2295499 1.000 rs2295499 chr4:2717690 A/G cg08330972 chr4:2403930 ZFYVE28 0.34 5.66 0.33 4e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs116095464 0.558 rs55776650 chr5:273826 G/A cg00938859 chr5:1591904 SDHAP3 0.64 6.95 0.39 2.88e-11 Breast cancer; CESC cis rs4722166 0.630 rs1581497 chr7:22779503 C/A cg13104385 chr7:22767384 IL6 0.48 6.43 0.37 5.96e-10 Lung cancer; CESC cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg24110177 chr3:50126178 RBM5 -0.53 -7.36 -0.41 2.33e-12 Intelligence (multi-trait analysis); CESC cis rs11997175 0.625 rs11991490 chr8:33595407 T/C ch.8.33884649F chr8:33765107 NA 0.54 6.91 0.39 3.67e-11 Body mass index; CESC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg24531977 chr5:56204891 C5orf35 -0.87 -10.87 -0.56 5.43e-23 Initial pursuit acceleration; CESC cis rs4523957 0.651 rs9895342 chr17:2081647 T/C cg16513277 chr17:2031491 SMG6 -0.71 -10.17 -0.53 1.04e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs709400 1.000 rs861539 chr14:104165753 G/A cg24130564 chr14:104152367 KLC1 -0.43 -5.41 -0.32 1.42e-7 Body mass index; CESC cis rs3096299 0.591 rs748940 chr16:89440757 T/A cg02187348 chr16:89574699 SPG7 0.54 7.03 0.4 1.72e-11 Multiple myeloma (IgH translocation); CESC cis rs11078597 0.650 rs62090056 chr17:1645410 C/T cg18436246 chr17:1640651 WDR81 0.62 7.53 0.42 7.83e-13 Serum albumin level; CESC cis rs17253792 0.822 rs12100753 chr14:56042870 G/A cg01858014 chr14:56050164 KTN1 -0.94 -7.69 -0.43 2.87e-13 Putamen volume; CESC cis rs2304069 0.545 rs1864998 chr5:149389465 C/T cg12661370 chr5:149340060 SLC26A2 0.47 6.27 0.36 1.49e-9 HIV-1 control; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14223017 chr19:2151266 AP3D1 0.57 6.75 0.38 9.08e-11 Gut microbiome composition (summer); CESC cis rs7592578 1.000 rs7592578 chr2:191439591 T/G cg10560079 chr2:191398806 TMEM194B 0.65 5.84 0.34 1.55e-8 Diastolic blood pressure; CESC cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg25019033 chr10:957182 NA -0.56 -5.57 -0.32 6.34e-8 Eosinophil percentage of granulocytes; CESC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg18876405 chr7:65276391 NA -0.54 -7.48 -0.42 1.09e-12 Aortic root size; CESC cis rs62458065 0.568 rs62463963 chr7:32486691 C/T cg20159608 chr7:32802032 NA -0.53 -5.08 -0.3 7.29e-7 Metabolite levels (HVA/MHPG ratio); CESC cis rs7617773 0.744 rs2125482 chr3:48323133 T/G cg11946769 chr3:48343235 NME6 0.82 10.95 0.56 2.9e-23 Coronary artery disease; CESC cis rs4974559 0.947 rs10000797 chr4:1345647 G/A cg02980000 chr4:1222292 CTBP1 0.7 6.48 0.37 4.4e-10 Systolic blood pressure; CESC cis rs854765 0.547 rs9913277 chr17:17919749 G/T cg04398451 chr17:18023971 MYO15A -0.71 -10.55 -0.54 5.77e-22 Total body bone mineral density; CESC cis rs16854884 0.683 rs2053211 chr3:143774592 C/T cg06585982 chr3:143692056 C3orf58 -0.51 -6.49 -0.37 4.21e-10 Economic and political preferences (feminism/equality); CESC cis rs208520 0.954 rs1468153 chr6:67009054 A/C cg07460842 chr6:66804631 NA 0.75 8.0 0.44 3.85e-14 Exhaled nitric oxide output; CESC cis rs858239 0.669 rs6461687 chr7:23116580 A/G cg27449745 chr7:23145252 KLHL7 -0.45 -5.82 -0.34 1.73e-8 Cerebrospinal fluid biomarker levels; CESC cis rs2742234 0.541 rs7096500 chr10:43712095 C/T cg15436174 chr10:43711423 RASGEF1A 0.47 5.51 0.32 8.67e-8 Hirschsprung disease; CESC trans rs4904167 0.805 rs11159637 chr14:84682116 G/C cg06870609 chr15:89787223 FANCI 0.46 6.06 0.35 4.73e-9 Autism spectrum disorder or schizophrenia; CESC cis rs863345 0.967 rs10489834 chr1:158521034 G/A cg12129480 chr1:158549410 OR10X1 -0.33 -6.51 -0.37 3.66e-10 Pneumococcal bacteremia; CESC cis rs6831352 0.918 rs29001214 chr4:100051733 A/G cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs2235544 0.579 rs11804837 chr1:54482915 G/A cg25741118 chr1:54482237 LDLRAD1 -0.23 -5.83 -0.34 1.58e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs2795502 0.766 rs947549 chr10:43265880 G/C cg20628663 chr10:43360327 NA -0.7 -7.56 -0.42 6.52e-13 Blood protein levels; CESC trans rs7839040 0.698 rs13268071 chr8:82930251 G/A cg14472086 chr9:107730925 NA -0.48 -6.41 -0.37 6.53e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs881375 0.678 rs7031752 chr9:123663482 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 7.56 0.42 6.71e-13 Rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24046888 chr2:46526785 EPAS1 -0.54 -6.62 -0.38 2e-10 Gut microbiome composition (summer); CESC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg18350739 chr11:68623251 NA 0.44 6.94 0.39 3.07e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02066925 chr22:35936722 RASD2 -0.45 -6.05 -0.35 4.94e-9 Gut microbiota (bacterial taxa); CESC trans rs2975734 0.709 rs4841298 chr8:10111637 G/A cg15556689 chr8:8085844 FLJ10661 -0.6 -6.82 -0.39 6.15e-11 Morning vs. evening chronotype;Chronotype; CESC cis rs116095464 0.558 rs112343653 chr5:257174 G/A cg22857025 chr5:266934 NA -1.29 -18.21 -0.75 1.29e-48 Breast cancer; CESC cis rs4820539 0.966 rs2157709 chr22:23457420 T/C cg14186256 chr22:23484241 RTDR1 0.82 14.81 0.67 1.47e-36 Bone mineral density; CESC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg19774624 chr17:42201019 HDAC5 0.65 8.44 0.46 2.04e-15 Total body bone mineral density; CESC cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg02275930 chr1:2372054 NA -0.5 -8.04 -0.44 3.06e-14 Non-obstructive azoospermia; CESC trans rs875971 0.965 rs6971509 chr7:65714970 G/T cg26939375 chr7:64535504 NA -0.46 -6.18 -0.35 2.39e-9 Aortic root size; CESC cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg03213289 chr20:61660250 NA 0.39 6.16 0.35 2.7e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg05564831 chr3:52568323 NT5DC2 -0.45 -7.02 -0.4 1.88e-11 Bipolar disorder; CESC trans rs11098499 0.863 rs36040693 chr4:120477616 A/G cg25214090 chr10:38739885 LOC399744 0.66 8.96 0.48 5.92e-17 Corneal astigmatism; CESC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg23711669 chr6:146136114 FBXO30 0.97 14.77 0.67 2.05e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs9287719 0.781 rs6714413 chr2:10758859 C/T cg02196655 chr2:10830764 NOL10 -0.36 -5.59 -0.32 5.58e-8 Prostate cancer; CESC cis rs11098499 0.863 rs3775847 chr4:120447642 A/C cg24375607 chr4:120327624 NA 0.43 5.22 0.31 3.68e-7 Corneal astigmatism; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23117447 chr6:34394069 RPS10 -0.52 -6.67 -0.38 1.48e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7216064 0.953 rs62086043 chr17:65968003 A/G cg07042672 chr17:66097459 LOC651250 -0.59 -6.53 -0.37 3.31e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7917772 0.503 rs11191325 chr10:104302933 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.33 0.41 2.81e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03634887 chr16:66730948 CMTM4 -0.43 -6.26 -0.36 1.5e-9 Gambling; CESC cis rs1023500 0.505 rs134888 chr22:42674281 C/T cg05082376 chr22:42548792 NA -0.38 -5.59 -0.32 5.66e-8 Schizophrenia; CESC cis rs7542091 0.635 rs985431 chr1:210043948 A/T cg22029157 chr1:209979665 IRF6 0.5 7.98 0.44 4.32e-14 Monobrow; CESC cis rs9325144 0.647 rs7487395 chr12:38865660 C/A cg26384229 chr12:38710491 ALG10B -0.56 -7.89 -0.44 8.02e-14 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07254608 chr8:41997973 NA -0.41 -6.0 -0.35 6.4e-9 Gambling; CESC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg07677032 chr17:61819896 STRADA 0.42 5.33 0.31 2.08e-7 Height; CESC cis rs887829 0.569 rs4124874 chr2:234665659 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -6.19 -0.36 2.27e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs287982 1.000 rs56154233 chr2:9969227 C/T cg10881225 chr2:9984929 TAF1B 0.39 5.06 0.3 7.7e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs6456156 0.586 rs1407315 chr6:167468659 A/G cg07741184 chr6:167504864 NA 0.36 6.17 0.35 2.48e-9 Primary biliary cholangitis; CESC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 10.22 0.53 6.88e-21 Platelet count; CESC cis rs11969893 0.850 rs9386260 chr6:101329428 G/A cg12253828 chr6:101329408 ASCC3 1.11 9.31 0.5 5.04e-18 Economic and political preferences (immigration/crime); CESC cis rs709400 0.930 rs28513222 chr14:104028069 A/T cg12935359 chr14:103987150 CKB -0.51 -6.56 -0.37 2.78e-10 Body mass index; CESC cis rs1322639 1.000 rs1322639 chr6:169587103 G/A cg04662567 chr6:169592167 NA 0.52 6.9 0.39 3.85e-11 Pulse pressure; CESC cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13941441 chr2:190649374 PMS1;ORMDL1 0.44 6.06 0.35 4.54e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg22968622 chr17:43663579 NA 0.77 10.56 0.54 5.65e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4523957 0.583 rs2760737 chr17:2024647 C/T cg16513277 chr17:2031491 SMG6 -0.71 -10.08 -0.53 1.96e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg05368731 chr17:41323189 NBR1 0.77 10.06 0.53 2.31e-20 Menopause (age at onset); CESC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg12463550 chr7:65579703 CRCP 0.56 7.07 0.4 1.39e-11 Aortic root size; CESC cis rs116095464 0.614 rs62344339 chr5:252995 T/G cg20965017 chr5:231967 SDHA -0.47 -5.22 -0.31 3.61e-7 Breast cancer; CESC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg12193833 chr17:30244370 NA 0.53 5.42 0.32 1.32e-7 Hip circumference adjusted for BMI; CESC cis rs796364 0.901 rs35572201 chr2:201035093 T/C cg23649088 chr2:200775458 C2orf69 -0.57 -5.62 -0.33 4.88e-8 Schizophrenia; CESC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg11890956 chr21:40555474 PSMG1 -0.62 -8.42 -0.46 2.33e-15 Menarche (age at onset); CESC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg26516362 chr5:178986906 RUFY1 -0.48 -7.91 -0.44 6.8e-14 Lung cancer; CESC cis rs2304069 0.954 rs1469691 chr5:149386716 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.91 11.66 0.58 1.21e-25 HIV-1 control; CESC cis rs2708240 0.905 rs2080154 chr7:147571529 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.54 -0.32 7.3900000000000007e-08 QT interval (drug interaction); CESC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.04 11.76 0.59 5.58e-26 Platelet count; CESC cis rs1865721 1.000 rs8096298 chr18:73187608 C/T cg26385618 chr18:73139727 C18orf62 -0.51 -7.6 -0.42 5.14e-13 Intelligence; CESC cis rs447 1.000 rs10261415 chr7:83760881 G/T cg22846510 chr7:83753280 SEMA3A -0.47 -5.87 -0.34 1.32e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs747782 0.528 rs10838881 chr11:48387275 T/C cg15704280 chr7:45808275 SEPT13 0.68 6.21 0.36 2.09e-9 Intraocular pressure; CESC cis rs17376456 0.877 rs17083455 chr5:93446380 A/C cg25358565 chr5:93447407 FAM172A 1.12 11.84 0.59 3.05e-26 Diabetic retinopathy; CESC cis rs7937682 0.814 rs1784788 chr11:111486136 T/G cg09085632 chr11:111637200 PPP2R1B -0.94 -14.43 -0.66 3.27e-35 Primary sclerosing cholangitis; CESC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg12463550 chr7:65579703 CRCP 0.56 7.06 0.4 1.44e-11 Aortic root size; CESC cis rs9910055 0.593 rs58392387 chr17:42297889 A/G cg19774624 chr17:42201019 HDAC5 -0.46 -5.9 -0.34 1.08e-8 Total body bone mineral density; CESC cis rs8031584 0.918 rs3817498 chr15:31268781 T/C cg14829155 chr15:31115871 NA -0.65 -8.53 -0.46 1.12e-15 Huntington's disease progression; CESC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg18252515 chr7:66147081 NA 0.47 6.17 0.35 2.57e-9 Aortic root size; CESC cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.89 -12.1 -0.6 3.95e-27 Multiple sclerosis; CESC cis rs7267979 0.738 rs2892409 chr20:25638138 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.71 11.83 0.59 3.42e-26 Liver enzyme levels (alkaline phosphatase); CESC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg04414720 chr1:150670196 GOLPH3L 0.58 7.54 0.42 7.34e-13 Melanoma; CESC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg18016565 chr1:150552671 MCL1 -0.34 -5.07 -0.3 7.65e-7 Urate levels; CESC trans rs561341 0.660 rs7406043 chr17:30220152 C/G cg27661571 chr11:113659931 NA -0.6 -6.15 -0.35 2.83e-9 Hip circumference adjusted for BMI; CESC cis rs847577 0.609 rs17435590 chr7:97784061 T/C cg24562669 chr7:97807699 LMTK2 0.82 13.45 0.64 8.74e-32 Breast cancer; CESC cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg17211192 chr8:82754475 SNX16 -0.7 -8.35 -0.46 3.95e-15 Diastolic blood pressure; CESC cis rs7714584 1.000 rs10051804 chr5:150226424 T/C cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs2070488 0.804 rs13092539 chr3:38458725 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.81 12.98 0.62 3.7e-30 Electrocardiographic conduction measures; CESC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg08888203 chr3:10149979 C3orf24 0.48 6.06 0.35 4.71e-9 Alzheimer's disease; CESC cis rs34779708 0.897 rs9665538 chr10:35461038 T/C cg04310649 chr10:35416472 CREM -0.53 -6.67 -0.38 1.48e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs963731 0.649 rs6756184 chr2:39256877 G/A cg04010122 chr2:39346883 SOS1 -0.75 -5.48 -0.32 9.69e-8 Corticobasal degeneration; CESC cis rs11203032 0.831 rs11203011 chr10:90931178 A/C cg16672925 chr10:90967113 CH25H 0.69 6.61 0.38 2.1e-10 Heart failure; CESC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg27170947 chr2:26402098 FAM59B -0.57 -6.76 -0.38 8.73e-11 Gut microbiome composition (summer); CESC cis rs4664308 1.000 rs925410 chr2:160912652 C/T cg03641300 chr2:160917029 PLA2R1 0.67 10.37 0.54 2.35e-21 Idiopathic membranous nephropathy; CESC cis rs7786808 0.504 rs10949725 chr7:158196003 C/T cg09998033 chr7:158218633 PTPRN2 0.36 5.62 0.33 4.93e-8 Obesity-related traits; CESC cis rs2228479 0.717 rs17226274 chr16:89850170 C/T cg00800038 chr16:89945340 TCF25 -0.89 -7.9 -0.44 7.67e-14 Skin colour saturation; CESC cis rs1003719 0.680 rs2835621 chr21:38510616 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.46 -0.46 1.79e-15 Eye color traits; CESC cis rs9583531 0.527 rs3818496 chr13:111358488 G/A cg24331049 chr13:111365604 ING1 0.71 10.88 0.56 4.81e-23 Coronary artery disease; CESC cis rs9486719 0.843 rs2472875 chr6:96844691 G/A cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs3824867 0.879 rs10769267 chr11:47460098 C/T cg20307385 chr11:47447363 PSMC3 0.5 6.06 0.35 4.73e-9 Mean corpuscular hemoglobin; CESC cis rs17401966 0.838 rs55676616 chr1:10290126 T/C cg15208524 chr1:10270712 KIF1B 0.42 5.4 0.32 1.46e-7 Hepatocellular carcinoma; CESC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg02038168 chr22:39784481 NA 0.65 8.16 0.45 1.38e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7020830 0.571 rs3780335 chr9:37376587 A/G cg14294708 chr9:37120828 ZCCHC7 -0.91 -10.3 -0.53 3.86e-21 Schizophrenia; CESC cis rs787274 0.718 rs1711745 chr9:115452909 C/A cg13803584 chr9:115635662 SNX30 0.54 5.17 0.3 4.67e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg08470875 chr2:26401718 FAM59B 0.63 6.48 0.37 4.45e-10 Gut microbiome composition (summer); CESC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg03576123 chr11:487126 PTDSS2 -1.12 -11.23 -0.57 3.5e-24 Body mass index; CESC trans rs61931739 0.534 rs10844800 chr12:34230734 A/G cg26384229 chr12:38710491 ALG10B 0.63 9.17 0.49 1.41e-17 Morning vs. evening chronotype; CESC cis rs5753618 0.583 rs7293171 chr22:31802324 T/C cg13145458 chr22:31556086 RNF185 -0.49 -5.56 -0.32 6.44e-8 Colorectal cancer; CESC cis rs2637266 0.703 rs4376842 chr10:78456250 C/T cg18941641 chr10:78392320 NA 0.41 7.42 0.41 1.55e-12 Pulmonary function; CESC trans rs1814175 0.817 rs10769618 chr11:49822336 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -20.12 -0.78 2.71e-55 Height; CESC cis rs11997175 0.603 rs716584 chr8:33779748 C/G ch.8.33884649F chr8:33765107 NA 0.5 6.09 0.35 4.02e-9 Body mass index; CESC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg22143856 chr6:28129313 ZNF389 0.51 6.49 0.37 4.19e-10 Depression; CESC cis rs9388451 0.874 rs9398787 chr6:126090608 A/G cg05901451 chr6:126070800 HEY2 -0.65 -9.31 -0.5 5.17e-18 Brugada syndrome; CESC cis rs11587400 0.656 rs12738051 chr1:115096964 A/G cg12756093 chr1:115239321 AMPD1 0.43 5.82 0.34 1.7e-8 Autism; CESC cis rs11190604 1.000 rs2003284 chr10:102202338 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs6964587 0.934 rs7793861 chr7:91742728 C/G cg17063962 chr7:91808500 NA 0.57 7.92 0.44 6.64e-14 Breast cancer; CESC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg08736216 chr1:53307985 ZYG11A 0.41 6.85 0.39 5.29e-11 Monocyte count; CESC trans rs10500991 0.587 rs7934559 chr11:24884066 A/G cg07129253 chr8:30890560 PURG;WRN -0.49 -6.54 -0.37 3.2e-10 Iron status biomarkers; CESC cis rs3916 0.955 rs34030695 chr12:121156496 G/A cg21892295 chr12:121157589 UNC119B -0.36 -5.26 -0.31 3.04e-7 Urinary metabolites (H-NMR features); CESC cis rs3736485 0.844 rs12593979 chr15:51741579 A/G cg08986416 chr15:51914746 DMXL2 0.4 5.1 0.3 6.45e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7927592 0.956 rs11228256 chr11:68251460 G/A cg20283391 chr11:68216788 NA -0.51 -6.17 -0.35 2.55e-9 Total body bone mineral density; CESC cis rs941873 0.868 rs7332 chr10:81114060 G/A cg11057378 chr10:81107060 PPIF 0.36 5.84 0.34 1.55e-8 Height; CESC cis rs10791097 0.967 rs4366492 chr11:130717256 T/C cg12179176 chr11:130786555 SNX19 0.58 8.19 0.45 1.14e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6754311 0.551 rs9287442 chr2:136522710 A/G cg15123519 chr2:136567270 LCT 0.33 5.64 0.33 4.29e-8 Mosquito bite size; CESC cis rs4889855 0.530 rs12603265 chr17:78618637 A/G cg16591659 chr17:78472290 NA -0.32 -5.16 -0.3 4.85e-7 Fractional excretion of uric acid; CESC cis rs4253772 0.591 rs11703435 chr22:46685563 C/T cg24881330 chr22:46731750 TRMU 0.75 5.43 0.32 1.25e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg18538332 chr22:24372958 LOC391322 -0.72 -10.75 -0.55 1.32e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg05313129 chr8:58192883 C8orf71 -0.56 -6.43 -0.37 5.99e-10 Developmental language disorder (linguistic errors); CESC cis rs868036 0.958 rs11635424 chr15:68037578 C/T cg08079166 chr15:68083412 MAP2K5 0.4 6.4 0.37 6.93e-10 Restless legs syndrome; CESC cis rs7095944 0.644 rs965484 chr10:126453481 T/C cg08799069 chr10:126477246 METTL10 -0.37 -5.28 -0.31 2.66e-7 Asthma; CESC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.45 0.8 7.14e-60 Prudent dietary pattern; CESC cis rs17253792 0.822 rs76555508 chr14:56071868 A/G cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg14784868 chr12:69753453 YEATS4 0.84 13.21 0.63 6.15e-31 Blood protein levels; CESC cis rs7017914 0.967 rs1348535 chr8:71662741 A/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.43 -5.41 -0.32 1.4e-7 Bone mineral density; CESC cis rs911555 0.755 rs4143998 chr14:103955247 T/C cg12935359 chr14:103987150 CKB -0.57 -8.24 -0.45 7.75e-15 Intelligence (multi-trait analysis); CESC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.71e-40 Aortic root size; CESC cis rs897984 0.572 rs4889526 chr16:31030344 C/A cg00531865 chr16:30841666 NA -0.4 -5.58 -0.32 5.95e-8 Dementia with Lewy bodies; CESC trans rs208520 0.565 rs1385222 chr6:66753013 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.98 18.55 0.75 8.14e-50 Exhaled nitric oxide output; CESC cis rs17362650 0.653 rs13001298 chr2:9550446 G/C cg12832956 chr2:9616023 IAH1 -0.55 -6.33 -0.36 1.05e-9 Alcohol dependence (age at onset); CESC cis rs1707322 0.506 rs2991983 chr1:46079391 T/C cg03146154 chr1:46216737 IPP -0.81 -11.23 -0.57 3.35e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs72781680 1.000 rs72796326 chr2:24137047 G/A cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC trans rs7943203 1.000 rs7952492 chr11:108296680 C/T cg01416241 chr5:148737479 PCYOX1L -0.48 -6.21 -0.36 2.08e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs4481887 0.790 rs4526648 chr1:248422503 A/T cg00666640 chr1:248458726 OR2T12 -0.33 -5.54 -0.32 7.29e-8 Common traits (Other); CESC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg06481639 chr22:41940642 POLR3H -0.61 -6.49 -0.37 4.09e-10 Vitiligo; CESC cis rs7000551 0.751 rs2449338 chr8:22369232 A/G cg12081754 chr8:22256438 SLC39A14 0.42 5.51 0.32 8.44e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg23758822 chr17:41437982 NA 1.04 16.01 0.7 7.99e-41 Menopause (age at onset); CESC cis rs2882667 0.858 rs11242444 chr5:138406379 T/A cg04439458 chr5:138467593 SIL1 -0.37 -5.78 -0.33 2.13e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs3857067 0.806 rs7678054 chr4:95093855 A/G cg11021082 chr4:95130006 SMARCAD1 0.58 8.51 0.46 1.3e-15 QT interval; CESC cis rs10206020 0.921 rs72776300 chr2:1571152 A/G cg26248373 chr2:1572462 NA -0.6 -6.98 -0.39 2.43e-11 IgG glycosylation; CESC cis rs4253772 0.591 rs11705624 chr22:46685380 C/T cg18190219 chr22:46762943 CELSR1 -0.59 -5.46 -0.32 1.09e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6539267 0.741 rs10861572 chr12:106688576 A/G cg02476566 chr12:106696527 TCP11L2 -0.57 -6.5 -0.37 4.06e-10 Tourette syndrome; CESC cis rs2425143 0.908 rs58448091 chr20:34325470 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.3 0.31 2.46e-7 Blood protein levels; CESC cis rs17253792 0.822 rs58589065 chr14:56152478 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.72 5.5 0.32 9.03e-8 Putamen volume; CESC cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs2228479 0.867 rs11646448 chr16:89966357 A/T cg14709524 chr16:89940631 TCF25 0.68 5.67 0.33 3.72e-8 Skin colour saturation; CESC cis rs12681366 0.762 rs7824722 chr8:95350851 A/T cg13257157 chr8:95487014 RAD54B 0.41 5.55 0.32 6.83e-8 Nonsyndromic cleft lip with cleft palate; CESC cis rs12497850 0.864 rs4521268 chr3:49137904 G/T cg02487422 chr3:49467188 NICN1 0.45 5.69 0.33 3.33e-8 Parkinson's disease; CESC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg22823121 chr1:150693482 HORMAD1 0.46 6.4 0.37 7.08e-10 Melanoma; CESC cis rs7255436 0.931 rs7249520 chr19:8446056 G/A cg16745616 chr19:8428856 ANGPTL4 -0.37 -5.67 -0.33 3.75e-8 HDL cholesterol; CESC cis rs7577696 0.512 rs9789593 chr2:32381110 T/G cg02381751 chr2:32503542 YIPF4 -0.44 -5.12 -0.3 5.83e-7 Inflammatory biomarkers; CESC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg07211511 chr3:129823064 LOC729375 -0.59 -7.28 -0.41 3.84e-12 Blood pressure (smoking interaction); CESC cis rs959260 1.000 rs7221050 chr17:73393949 A/T cg20590849 chr17:73267439 MIF4GD -0.56 -6.59 -0.38 2.39e-10 Systemic lupus erythematosus; CESC cis rs1580019 0.563 rs2392071 chr7:32572536 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.38 0.36 8.07e-10 Cognitive ability; CESC cis rs55692411 0.537 rs35012435 chr3:50031840 C/T cg24308560 chr3:49941425 MST1R -0.53 -6.39 -0.37 7.35e-10 Intelligence (multi-trait analysis); CESC cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 8.79 0.47 1.99e-16 Hip circumference adjusted for BMI; CESC cis rs1005277 0.522 rs7090858 chr10:38003670 A/C cg00409905 chr10:38381863 ZNF37A 0.52 7.16 0.4 8.05e-12 Extrinsic epigenetic age acceleration; CESC cis rs1003719 0.715 rs2835653 chr21:38558636 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.13 -0.45 1.62e-14 Eye color traits; CESC cis rs7666738 0.830 rs28867087 chr4:98880349 T/A cg17366294 chr4:99064904 C4orf37 0.56 7.87 0.44 9.05e-14 Colonoscopy-negative controls vs population controls; CESC cis rs8028182 0.501 rs7166281 chr15:75928192 G/T cg20655648 chr15:75932815 IMP3 -0.53 -6.63 -0.38 1.88e-10 Sudden cardiac arrest; CESC cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.45 6.04 0.35 5.28e-9 Personality dimensions; CESC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg18904891 chr8:8559673 CLDN23 0.7 7.82 0.43 1.26e-13 Obesity-related traits; CESC cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1801251 1.000 rs2675971 chr2:233726154 A/G cg25237894 chr2:233734115 C2orf82 -0.48 -8.13 -0.45 1.61e-14 Coronary artery disease; CESC cis rs7647973 1.000 rs9862534 chr3:49598064 A/G cg06212747 chr3:49208901 KLHDC8B 0.61 7.98 0.44 4.36e-14 Menarche (age at onset); CESC cis rs67311347 0.544 rs35112505 chr3:40337075 A/G cg09455208 chr3:40491958 NA 0.37 6.51 0.37 3.82e-10 Renal cell carcinoma; CESC cis rs25645 0.800 rs34003767 chr17:38194296 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.54 7.42 0.41 1.61e-12 Myeloid white cell count; CESC cis rs7587476 0.862 rs13001462 chr2:215678346 G/A cg04004882 chr2:215674386 BARD1 0.54 6.05 0.35 4.81e-9 Neuroblastoma; CESC cis rs344364 0.511 rs1657134 chr16:1953127 A/G cg26617929 chr16:1858877 NA -0.5 -5.24 -0.31 3.25e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs2032447 0.530 rs9356996 chr6:26008487 C/A cg18357526 chr6:26021779 HIST1H4A 0.44 6.23 0.36 1.78e-9 Intelligence (multi-trait analysis); CESC cis rs1801251 0.963 rs35395584 chr2:233573698 G/C cg08000102 chr2:233561755 GIGYF2 0.68 9.19 0.49 1.17e-17 Coronary artery disease; CESC cis rs10979 0.644 rs12527367 chr6:143918718 C/T cg25407410 chr6:143891975 LOC285740 -0.43 -5.82 -0.34 1.67e-8 Hypospadias; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18190534 chr8:142225894 SLC45A4 0.47 6.63 0.38 1.84e-10 Fibrinogen levels; CESC cis rs1707322 0.506 rs2991983 chr1:46079391 T/C cg05343316 chr1:45956843 TESK2 -0.53 -6.53 -0.37 3.25e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3768617 0.754 rs6673768 chr1:182983396 G/T ch.1.3577855R chr1:183094577 LAMC1 0.65 8.95 0.48 6.53e-17 Fuchs's corneal dystrophy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22982014 chr19:39322497 ECH1 -0.41 -6.17 -0.35 2.48e-9 Gambling; CESC cis rs2652822 0.933 rs7170846 chr15:63449543 A/C cg02713581 chr15:63449717 RPS27L 0.58 7.59 0.42 5.62e-13 Metabolic traits; CESC cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.83 0.34 1.58e-8 Colonoscopy-negative controls vs population controls; CESC cis rs17376456 0.569 rs7701114 chr5:93096028 T/C cg21475434 chr5:93447410 FAM172A 0.49 5.04 0.3 8.6e-7 Diabetic retinopathy; CESC cis rs8103278 0.826 rs11669442 chr19:46374557 A/G cg11657440 chr19:46296263 DMWD -0.46 -5.74 -0.33 2.59e-8 Coronary artery disease; CESC cis rs9911578 0.967 rs6416932 chr17:57148991 G/A cg12560992 chr17:57184187 TRIM37 1.0 17.39 0.73 9.99e-46 Intelligence (multi-trait analysis); CESC cis rs483180 0.855 rs562038 chr1:120254545 G/C cg19096424 chr1:120255104 PHGDH 0.71 8.69 0.47 3.78e-16 Macular telangiectasia type 2; CESC cis rs7666738 0.830 rs13144564 chr4:98939276 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2273669 0.667 rs11752532 chr6:109335969 C/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs1355223 0.902 rs61881050 chr11:34719749 G/A cg11058730 chr11:34937778 PDHX;APIP -0.46 -5.9 -0.34 1.09e-8 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs62005083 1.000 rs45538635 chr14:74485592 G/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.69 5.12 0.3 6.01e-7 Mean corpuscular volume; CESC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.43 -0.37 5.77e-10 Electroencephalogram traits; CESC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs10751667 0.666 rs7103585 chr11:971166 T/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.49e-7 Alzheimer's disease (late onset); CESC cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg25517755 chr10:38738941 LOC399744 -0.46 -5.98 -0.34 7.15e-9 Extrinsic epigenetic age acceleration; CESC cis rs6460942 0.597 rs17277369 chr7:12536192 A/G cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC cis rs14403 0.519 rs2994339 chr1:243641420 A/G cg21452805 chr1:244014465 NA 0.5 5.44 0.32 1.24e-7 Schizophrenia; CESC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg25036284 chr2:26402008 FAM59B -0.61 -7.08 -0.4 1.31e-11 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs55895244 chr7:65387678 C/G cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg11890956 chr21:40555474 PSMG1 -0.69 -9.97 -0.52 4.48e-20 Menarche (age at onset); CESC cis rs6460942 0.545 rs17448114 chr7:12524458 G/C cg02935154 chr7:12443704 VWDE -0.55 -5.53 -0.32 7.71e-8 Coronary artery disease; CESC cis rs6545883 0.929 rs12612982 chr2:61747355 G/A cg15711740 chr2:61764176 XPO1 -0.41 -5.07 -0.3 7.32e-7 Tuberculosis; CESC cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24704015 chr2:230931896 SLC16A14 -0.5 -6.59 -0.38 2.31e-10 Ulcerative colitis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04127825 chr1:167503222 NA -0.44 -6.02 -0.35 5.77e-9 Height; CESC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg06108461 chr20:60628389 TAF4 -0.79 -10.49 -0.54 9.03e-22 Body mass index; CESC cis rs992157 0.798 rs2382819 chr2:219155909 G/T cg20019365 chr2:219134978 PNKD;AAMP -0.66 -8.74 -0.47 2.72e-16 Colorectal cancer; CESC cis rs793571 0.744 rs4775097 chr15:59140801 C/T cg05156742 chr15:59063176 FAM63B -0.56 -6.88 -0.39 4.2e-11 Schizophrenia; CESC cis rs7589728 1.000 rs75309929 chr2:88524377 T/C cg04511125 chr2:88470314 THNSL2 0.58 5.62 0.33 4.78e-8 Plasma clusterin levels; CESC cis rs2274273 1.000 rs2147972 chr14:55598030 T/C cg04306507 chr14:55594613 LGALS3 0.29 5.16 0.3 4.74e-7 Protein biomarker; CESC trans rs11098499 0.955 rs13114751 chr4:120156617 G/A cg25214090 chr10:38739885 LOC399744 0.64 8.57 0.47 8.82e-16 Corneal astigmatism; CESC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg06634786 chr22:41940651 POLR3H -0.62 -6.61 -0.38 2.15e-10 Vitiligo; CESC cis rs7017914 0.967 rs1596566 chr8:71698576 A/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.3 -0.31 2.38e-7 Bone mineral density; CESC cis rs2243480 0.901 rs778730 chr7:65823325 T/A cg12463550 chr7:65579703 CRCP 0.68 5.26 0.31 2.94e-7 Diabetic kidney disease; CESC cis rs7640424 0.652 rs12152307 chr3:107861766 T/C cg09227934 chr3:107805635 CD47 -0.47 -6.13 -0.35 3.24e-9 Body mass index; CESC cis rs9916302 0.904 rs12452880 chr17:37591149 G/C cg07936489 chr17:37558343 FBXL20 -0.81 -11.75 -0.59 6.21e-26 Glomerular filtration rate (creatinine); CESC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.51 6.31 0.36 1.19e-9 Prudent dietary pattern; CESC cis rs12699921 0.526 rs12699916 chr7:17908546 C/T cg00911873 chr7:18067463 PRPS1L1 0.39 5.71 0.33 3.01e-8 Fibrinogen levels; CESC trans rs7582180 0.700 rs1437971 chr2:100986964 A/C cg22900798 chr8:23315430 ENTPD4 0.63 6.33 0.36 1.02e-9 Intelligence (multi-trait analysis); CESC cis rs12142240 0.698 rs55971480 chr1:46823206 G/T cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20589815 chr10:47656205 NA 0.53 6.03 0.35 5.51e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.592 rs9611612 chr22:41961189 T/C cg03806693 chr22:41940476 POLR3H -0.98 -12.2 -0.6 1.83e-27 Vitiligo; CESC cis rs9300255 0.543 rs520088 chr12:123522150 C/G cg05973401 chr12:123451056 ABCB9 0.58 6.59 0.38 2.36e-10 Neutrophil percentage of white cells; CESC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs12142240 0.698 rs17357621 chr1:46807697 C/T cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC trans rs4129059 0.765 rs72759626 chr1:214689619 T/C cg08821431 chr12:34491090 NA 0.54 6.33 0.36 1.04e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg18337363 chr3:52569053 NT5DC2 0.3 5.79 0.34 1.99e-8 Electroencephalogram traits; CESC cis rs933688 1.000 rs10073935 chr5:90742188 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 14.08 0.65 5.45e-34 Smoking behavior; CESC cis rs7336332 0.598 rs76249173 chr13:28010445 A/G cg01674679 chr13:27998804 GTF3A -0.58 -5.34 -0.31 2.04e-7 Weight; CESC cis rs9908102 0.740 rs59763012 chr17:12904636 C/T cg26162695 chr17:12921313 ELAC2 0.5 5.54 0.32 7.32e-8 Schizophrenia; CESC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.41e-28 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12446722 chr1:226374380 ACBD3 -0.46 -6.03 -0.35 5.37e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14134153 chr5:172386668 RPL26L1;LOC100268168 -0.55 -6.29 -0.36 1.33e-9 Gut microbiome composition (summer); CESC cis rs11785693 0.862 rs62491196 chr8:4995690 C/T cg26367366 chr8:4980734 NA 0.83 7.83 0.43 1.16e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg10351095 chr21:47802916 PCNT 0.43 5.55 0.32 7.02e-8 Testicular germ cell tumor; CESC cis rs113835537 0.935 rs57043177 chr11:66423147 A/G cg24851651 chr11:66362959 CCS 0.63 5.68 0.33 3.48e-8 Airway imaging phenotypes; CESC cis rs7520050 0.807 rs72688483 chr1:46149209 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.8 0.34 1.88e-8 Red blood cell count;Reticulocyte count; CESC cis rs36096196 0.891 rs12081179 chr1:2251119 A/G cg17974515 chr1:2252516 NA 0.45 7.49 0.42 1.04e-12 Coronary artery disease; CESC cis rs2952156 1.000 rs1565923 chr17:37858678 A/G cg00129232 chr17:37814104 STARD3 -0.68 -8.56 -0.47 9.14e-16 Asthma; CESC cis rs941873 0.803 rs5015119 chr10:81101609 G/C cg09469691 chr10:81107165 PPIF 0.57 7.75 0.43 1.96e-13 Height; CESC cis rs9354308 0.899 rs2802057 chr6:66548093 A/C cg07460842 chr6:66804631 NA 0.58 6.53 0.37 3.29e-10 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25833238 chr6:153304325 FBXO5 0.63 7.69 0.43 2.98e-13 Gut microbiome composition (summer); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg08060248 chr16:84213494 TAF1C 0.41 6.02 0.35 5.79e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs453301 0.658 rs6983877 chr8:8904639 T/C cg06636001 chr8:8085503 FLJ10661 -0.43 -5.3 -0.31 2.49e-7 Joint mobility (Beighton score); CESC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg19717773 chr7:2847554 GNA12 -0.57 -8.1 -0.45 2.06e-14 Height; CESC cis rs9549367 0.713 rs56002882 chr13:113830694 T/C cg00898013 chr13:113819073 PROZ -0.53 -7.25 -0.41 4.68e-12 Platelet distribution width; CESC cis rs61935443 1.000 rs4761691 chr12:95248171 C/G cg21533806 chr12:95267307 NA 0.51 6.46 0.37 4.89e-10 Schizophrenia; CESC cis rs7246865 0.510 rs6512161 chr19:17171582 A/G cg16202187 chr19:17186497 HAUS8;MYO9B 0.48 6.28 0.36 1.38e-9 Reticulocyte fraction of red cells; CESC cis rs524281 0.637 rs7126075 chr11:65940563 T/G cg14036092 chr11:66035641 RAB1B -0.56 -5.49 -0.32 9.43e-8 Electroencephalogram traits; CESC cis rs713587 0.520 rs1530016 chr2:25305756 C/T cg01884057 chr2:25150051 NA -0.3 -5.15 -0.3 5.08e-7 Body mass index in non-asthmatics; CESC cis rs1568889 0.667 rs7123947 chr11:28399908 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 8.14 0.45 1.59e-14 Bipolar disorder; CESC cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg24829409 chr8:58192753 C8orf71 -0.7 -9.11 -0.49 2.02e-17 Developmental language disorder (linguistic errors); CESC cis rs7833986 0.501 rs2719259 chr8:56941630 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.4 0.41 1.78e-12 Height; CESC cis rs2197308 0.740 rs11182251 chr12:37919611 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.23 -0.41 5.25e-12 Morning vs. evening chronotype; CESC cis rs6088580 0.634 rs945673 chr20:32964265 C/A cg06115741 chr20:33292138 TP53INP2 -0.46 -5.84 -0.34 1.49e-8 Glomerular filtration rate (creatinine); CESC cis rs6540556 0.723 rs1999826 chr1:209919275 C/T cg05527609 chr1:210001259 C1orf107 -0.48 -5.79 -0.33 2.04e-8 Red blood cell count; CESC cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg25517755 chr10:38738941 LOC399744 -0.47 -6.04 -0.35 5.12e-9 Extrinsic epigenetic age acceleration; CESC cis rs9911578 1.000 rs6503866 chr17:56619581 C/T cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.5e-11 Intelligence (multi-trait analysis); CESC cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg06212747 chr3:49208901 KLHDC8B -0.73 -10.22 -0.53 6.79e-21 Menarche (age at onset); CESC cis rs11785400 0.793 rs4457308 chr8:143733922 G/A cg24634471 chr8:143751801 JRK 0.47 6.03 0.35 5.44e-9 Schizophrenia; CESC cis rs1879734 0.636 rs11206202 chr1:54174607 A/G cg23596471 chr1:54105337 GLIS1 0.32 5.17 0.3 4.7e-7 Mitral valve prolapse; CESC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg05340658 chr4:99064831 C4orf37 0.81 12.59 0.61 8.13e-29 Colonoscopy-negative controls vs population controls; CESC cis rs1670533 1.000 rs10026482 chr4:1051128 C/G cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.77e-7 Recombination rate (females); CESC trans rs35110281 0.805 rs2838317 chr21:44991791 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 6.89 0.39 4.12e-11 Mean corpuscular volume; CESC cis rs16895831 0.531 rs12195803 chr6:42527571 G/A cg10605015 chr6:42532144 UBR2 -0.52 -5.63 -0.33 4.51e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs7847628 0.765 rs10985024 chr9:123516812 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.62 7.75 0.43 2.01e-13 Birth weight; CESC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC trans rs208520 0.526 rs4710310 chr6:66802808 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -24.8 -0.84 4.86e-71 Exhaled nitric oxide output; CESC cis rs1042058 0.565 rs2480297 chr10:30754512 A/G cg18806716 chr10:30721971 MAP3K8 -0.53 -8.02 -0.44 3.51e-14 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06812651 chr1:234746099 IRF2BP2 -0.53 -6.45 -0.37 5.23e-10 Ulcerative colitis; CESC cis rs9790314 1.000 rs6794601 chr3:160946769 C/T cg03342759 chr3:160939853 NMD3 -0.55 -7.52 -0.42 8.47e-13 Morning vs. evening chronotype; CESC cis rs7666738 0.819 rs62318904 chr4:99036101 A/T cg03467027 chr4:99064603 C4orf37 0.48 5.92 0.34 9.73e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9297145 0.678 rs62473048 chr7:98775511 T/C cg05967295 chr7:98741636 SMURF1 0.85 8.9 0.48 8.82e-17 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC trans rs877282 0.945 rs11253396 chr10:789754 C/T cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs7927771 0.524 rs10769299 chr11:47865160 G/T cg18512352 chr11:47633146 NA 0.35 5.44 0.32 1.23e-7 Subjective well-being; CESC cis rs7666738 0.830 rs11944035 chr4:98931618 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC cis rs3087591 0.922 rs12950506 chr17:29598392 A/G cg24425628 chr17:29625626 OMG;NF1 0.43 5.35 0.31 1.87e-7 Hip circumference; CESC cis rs2235642 0.750 rs2755185 chr16:1645827 A/G cg03715980 chr16:1756201 MAPK8IP3 0.4 5.24 0.31 3.33e-7 Coronary artery disease; CESC trans rs7839040 0.698 rs13249724 chr8:82931502 A/G cg14472086 chr9:107730925 NA -0.48 -6.45 -0.37 5.18e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs11864453 0.647 rs3764311 chr16:72125617 C/G cg16558253 chr16:72132732 DHX38 -0.55 -8.54 -0.46 1.08e-15 Fibrinogen levels; CESC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg15921436 chr17:44337874 NA 0.43 5.3 0.31 2.38e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg23158103 chr7:148848205 ZNF398 -0.4 -6.32 -0.36 1.08e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6032067 0.929 rs6017511 chr20:43833132 C/T cg10761708 chr20:43804764 PI3 0.52 6.32 0.36 1.07e-9 Blood protein levels; CESC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg03576123 chr11:487126 PTDSS2 -1.12 -11.21 -0.57 3.93e-24 Body mass index; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23543263 chr13:22245177 FGF9 0.51 6.4 0.37 7.16e-10 Intelligence (multi-trait analysis); CESC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg17971929 chr21:40555470 PSMG1 -0.86 -12.5 -0.61 1.7e-28 Cognitive function; CESC cis rs9916302 0.653 rs11654954 chr17:37745979 C/T cg00129232 chr17:37814104 STARD3 0.59 5.55 0.32 6.82e-8 Glomerular filtration rate (creatinine); CESC cis rs909002 1.000 rs909002 chr1:32139635 C/T cg13919466 chr1:32135498 COL16A1 -0.51 -9.57 -0.51 7.94e-19 Intelligence (multi-trait analysis); CESC cis rs36051895 0.664 rs10115172 chr9:5098549 C/T cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.61e-9 Pediatric autoimmune diseases; CESC cis rs2637266 0.745 rs241 chr10:78444456 G/T cg18941641 chr10:78392320 NA 0.44 7.95 0.44 5.38e-14 Pulmonary function; CESC cis rs6430585 0.583 rs3769001 chr2:136626078 A/G cg07169764 chr2:136633963 MCM6 1.29 19.86 0.77 2.13e-54 Corneal structure; CESC cis rs7208859 0.673 rs216440 chr17:28928309 A/T cg14008862 chr17:28927542 LRRC37B2 0.61 5.87 0.34 1.27e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs708547 0.836 rs1625691 chr4:57845740 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.58 -6.87 -0.39 4.63e-11 Response to bleomycin (chromatid breaks); CESC cis rs9611565 0.559 rs5751160 chr22:42175695 A/G cg17376030 chr22:41985996 PMM1 -0.79 -8.37 -0.46 3.44e-15 Vitiligo; CESC cis rs9911578 0.933 rs74370218 chr17:57095212 C/T cg12560992 chr17:57184187 TRIM37 -1.0 -17.63 -0.73 1.4300000000000001e-46 Intelligence (multi-trait analysis); CESC cis rs1801251 0.711 rs2592117 chr2:233735693 C/T cg08000102 chr2:233561755 GIGYF2 -0.58 -7.82 -0.43 1.22e-13 Coronary artery disease; CESC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg07677032 chr17:61819896 STRADA 0.45 6.01 0.35 6.14e-9 Prudent dietary pattern; CESC cis rs854765 0.587 rs4077828 chr17:17833644 A/T cg04398451 chr17:18023971 MYO15A -0.67 -9.61 -0.51 6.01e-19 Total body bone mineral density; CESC cis rs2228479 0.850 rs62052212 chr16:89981960 G/A cg00800038 chr16:89945340 TCF25 -0.91 -7.41 -0.41 1.67e-12 Skin colour saturation; CESC cis rs7259376 0.905 rs2082479 chr19:22539847 T/C cg02657401 chr19:22469223 NA -0.25 -5.08 -0.3 7.12e-7 Menopause (age at onset); CESC cis rs3747547 0.892 rs11789441 chr9:37993303 G/T cg13774184 chr9:37916125 SHB -0.73 -6.3 -0.36 1.22e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.66 9.08 0.49 2.51e-17 Menopause (age at onset); CESC cis rs7605827 0.930 rs6732252 chr2:15595473 T/C cg19274914 chr2:15703543 NA 0.31 5.45 0.32 1.13e-7 Educational attainment (years of education); CESC cis rs17253792 0.822 rs77182097 chr14:56136695 G/A cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs3947 1.000 rs1736085 chr8:11703659 T/C cg00262122 chr8:11665843 FDFT1 -0.51 -5.04 -0.3 8.69e-7 Blood protein levels; CESC cis rs11719291 0.584 rs13080725 chr3:49076092 G/A cg00383909 chr3:49044727 WDR6 0.92 6.59 0.38 2.35e-10 Cognitive function; CESC cis rs1355223 0.902 rs1597962 chr11:34727172 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.24 -0.36 1.68e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7071206 0.947 rs4979905 chr10:79416367 C/T cg00983440 chr10:79422392 NA -0.67 -8.2 -0.45 1.02e-14 Bone mineral density; CESC cis rs11190604 1.000 rs2495755 chr10:102324649 A/C cg07080220 chr10:102295463 HIF1AN 0.62 5.57 0.32 6.31e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7714584 1.000 rs11167515 chr5:150239471 G/T cg22134413 chr5:150180641 NA 0.57 5.4 0.32 1.45e-7 Crohn's disease; CESC cis rs17376456 0.825 rs13171131 chr5:93223028 C/T cg21475434 chr5:93447410 FAM172A 0.83 7.21 0.41 5.8e-12 Diabetic retinopathy; CESC cis rs711830 1.000 rs2249131 chr2:177032095 C/T cg13092806 chr2:177043255 NA 0.87 11.79 0.59 4.66e-26 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CESC cis rs7927771 1.000 rs11039412 chr11:47841581 G/A cg18512352 chr11:47633146 NA -0.6 -9.57 -0.51 8.16e-19 Subjective well-being; CESC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg23985595 chr17:80112537 CCDC57 0.42 6.47 0.37 4.65e-10 Life satisfaction; CESC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg21770322 chr7:97807741 LMTK2 0.58 8.49 0.46 1.53e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs9611565 0.649 rs5758434 chr22:42116163 G/A cg03806693 chr22:41940476 POLR3H 0.76 9.27 0.49 6.64e-18 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17170446 chr11:16759907 C11orf58 -0.63 -7.36 -0.41 2.34e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04266179 chr19:42746555 GSK3A 0.55 6.09 0.35 3.99e-9 Gut microbiome composition (summer); CESC cis rs11645898 0.935 rs11640722 chr16:72172300 C/T cg14768367 chr16:72042858 DHODH -0.76 -6.49 -0.37 4.28e-10 Blood protein levels; CESC cis rs2051211 0.947 rs73065216 chr3:38524194 G/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.66 -7.41 -0.41 1.65e-12 QRS duration; CESC cis rs9831754 0.704 rs1512491 chr3:78470954 T/C cg06138941 chr3:78371609 NA 0.4 5.17 0.3 4.63e-7 Calcium levels; CESC cis rs2832077 0.527 rs1048546 chr21:30244877 G/T cg08807101 chr21:30365312 RNF160 -0.51 -6.21 -0.36 2.04e-9 Cognitive test performance; CESC cis rs503341 0.756 rs480874 chr11:63591965 A/T cg04362095 chr11:63592001 C11orf84 -0.58 -8.42 -0.46 2.4e-15 Pulse pressure; CESC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg09177884 chr7:1199841 ZFAND2A -0.53 -7.07 -0.4 1.37e-11 Longevity;Endometriosis; CESC cis rs2204008 0.529 rs1315350 chr12:38164282 C/A cg26384229 chr12:38710491 ALG10B -0.41 -5.66 -0.33 3.98e-8 Bladder cancer; CESC cis rs11123694 1.000 rs11123694 chr2:109064563 C/T cg20520273 chr2:109403139 CCDC138 -0.4 -5.09 -0.3 6.75e-7 Mean platelet volume; CESC cis rs9814567 0.752 rs13075253 chr3:134329600 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.43 5.6 0.33 5.39e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7301826 0.651 rs34749116 chr12:131280752 G/A cg11011512 chr12:131303247 STX2 -0.44 -5.36 -0.31 1.81e-7 Plasma plasminogen activator levels; CESC cis rs11078597 0.731 rs2070863 chr17:1648502 C/T cg18436246 chr17:1640651 WDR81 0.62 7.5 0.42 9.49e-13 Serum albumin level; CESC cis rs35110281 0.720 rs162400 chr21:44950305 A/C cg01579765 chr21:45077557 HSF2BP -0.54 -9.23 -0.49 8.75e-18 Mean corpuscular volume; CESC cis rs6942756 0.712 rs6467241 chr7:128997838 A/G cg02491457 chr7:128862824 NA -0.61 -8.52 -0.46 1.22e-15 White matter hyperintensity burden; CESC cis rs17601876 0.778 rs11632926 chr15:51564226 G/A cg19946085 chr15:51559439 CYP19A1 -0.32 -5.04 -0.3 8.53e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg09658497 chr7:2847517 GNA12 -0.37 -5.45 -0.32 1.16e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11095632 chr20:56063618 HMGB1L1 -0.52 -6.19 -0.36 2.34e-9 Gut microbiome composition (summer); CESC cis rs7615952 0.673 rs35955861 chr3:125626201 T/C cg05084668 chr3:125655381 ALG1L -0.77 -7.99 -0.44 4.09e-14 Blood pressure (smoking interaction); CESC cis rs854765 0.583 rs8065416 chr17:17851162 C/T cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC cis rs7937682 0.847 rs500163 chr11:111462649 T/G cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC cis rs3540 0.576 rs12907587 chr15:91045851 G/C cg10434728 chr15:90938212 IQGAP1 -0.42 -7.65 -0.43 3.62e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg20735954 chr22:39777886 SYNGR1 -0.41 -5.07 -0.3 7.62e-7 Intelligence (multi-trait analysis); CESC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg04414720 chr1:150670196 GOLPH3L 0.49 6.47 0.37 4.81e-10 Melanoma; CESC cis rs4718428 0.705 rs68168107 chr7:66255238 G/A cg18252515 chr7:66147081 NA -0.45 -5.04 -0.3 8.7e-7 Corneal structure; CESC cis rs9796 0.870 rs8023345 chr15:41338348 T/G cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.86 -0.39 4.82e-11 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16629158 chr2:122042988 TFCP2L1 -0.47 -6.7 -0.38 1.23e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9400271 0.632 rs9487020 chr6:109587672 A/G cg01475377 chr6:109611718 NA -0.46 -7.18 -0.4 7.24e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs2380220 0.606 rs9488080 chr6:96006973 A/G cg04719120 chr6:96025338 MANEA 0.51 5.91 0.34 1.02e-8 Behavioural disinhibition (generation interaction); CESC cis rs3806843 1.000 rs7710794 chr5:140209467 T/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.25 -0.31 3.08e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9467711 0.606 rs12174639 chr6:26373121 G/A cg14345882 chr6:26364793 BTN3A2 0.61 6.43 0.37 5.97e-10 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13518988 chr17:73401817 GRB2 0.55 6.02 0.35 5.85e-9 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.33e-10 Skin colour saturation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22175779 chr15:57998734 GRINL1A;GCOM1 0.41 6.31 0.36 1.15e-9 Gambling; CESC cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.84 13.46 0.64 7.82e-32 Hip circumference adjusted for BMI; CESC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg12463550 chr7:65579703 CRCP -0.48 -6.03 -0.35 5.35e-9 Aortic root size; CESC cis rs7666738 0.830 rs34212748 chr4:99068708 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.5 0.46 1.41e-15 Colonoscopy-negative controls vs population controls; CESC cis rs3008870 1.000 rs7511948 chr1:67430427 A/G cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg25554036 chr4:6271136 WFS1 0.55 9.09 0.49 2.42e-17 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1878931 0.559 rs2106863 chr16:3391330 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.69 8.49 0.46 1.49e-15 Body mass index (adult); CESC trans rs983392 0.805 rs11230184 chr11:59965789 G/A cg02363969 chr19:56048075 SBK2 0.41 6.12 0.35 3.39e-9 Alzheimer's disease (late onset); CESC trans rs11098499 0.863 rs3775844 chr4:120428033 G/A cg25214090 chr10:38739885 LOC399744 0.71 9.77 0.51 1.88e-19 Corneal astigmatism; CESC trans rs9858542 0.903 rs11921590 chr3:49644193 T/C cg21659725 chr3:3221576 CRBN -0.52 -6.34 -0.36 9.97e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6459804 0.967 rs10233396 chr7:157512290 C/T cg05731713 chr7:157510257 PTPRN2 0.38 6.18 0.35 2.44e-9 Bipolar disorder and schizophrenia; CESC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.75 -0.33 2.42e-8 Total body bone mineral density; CESC cis rs1348850 0.574 rs4893835 chr2:178442592 T/C cg22681709 chr2:178499509 PDE11A -0.44 -5.18 -0.3 4.4e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16780939 chr12:56753945 STAT2 -0.47 -6.46 -0.37 4.99e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9457247 0.624 rs2239826 chr6:167504880 T/C cg23791538 chr6:167370224 RNASET2 -0.53 -6.78 -0.38 7.7e-11 Crohn's disease; CESC cis rs4561483 0.582 rs3850997 chr16:12043512 G/T cg08843971 chr16:11963173 GSPT1 -0.41 -5.47 -0.32 1.04e-7 Testicular germ cell tumor; CESC cis rs7809950 0.954 rs62482543 chr7:107080656 G/A cg23024343 chr7:107201750 COG5 -0.41 -5.89 -0.34 1.19e-8 Coronary artery disease; CESC cis rs858239 0.601 rs12539331 chr7:23151330 A/G cg23682824 chr7:23144976 KLHL7 0.46 6.0 0.35 6.55e-9 Cerebrospinal fluid biomarker levels; CESC cis rs2408955 0.521 rs10875753 chr12:48557141 C/T cg04545296 chr12:48745243 ZNF641 0.32 5.57 0.32 6.26e-8 Glycated hemoglobin levels; CESC cis rs992157 0.798 rs4996257 chr2:219162836 C/T cg00012203 chr2:219082015 ARPC2 0.76 10.05 0.53 2.51e-20 Colorectal cancer; CESC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg11764359 chr7:65958608 NA 0.79 11.17 0.57 5.2e-24 Aortic root size; CESC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg12963246 chr6:28129442 ZNF389 0.49 6.32 0.36 1.09e-9 Parkinson's disease; CESC cis rs7772486 0.875 rs2777476 chr6:146345024 A/G cg05347473 chr6:146136440 FBXO30 0.52 6.71 0.38 1.17e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7555523 0.887 rs2251768 chr1:165738311 A/T cg24409356 chr1:165738333 TMCO1 0.94 8.44 0.46 2.08e-15 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs7208859 0.573 rs73267873 chr17:29068457 C/T cg14008862 chr17:28927542 LRRC37B2 0.63 5.27 0.31 2.89e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs561341 0.739 rs4795663 chr17:30214542 T/C cg20587970 chr11:113659929 NA 0.57 7.55 0.42 7.15e-13 Hip circumference adjusted for BMI; CESC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg23978390 chr7:1156363 C7orf50 0.65 9.33 0.5 4.39e-18 Longevity;Endometriosis; CESC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Tonsillectomy; CESC cis rs9300255 0.739 rs4759417 chr12:123746510 C/T cg05973401 chr12:123451056 ABCB9 0.5 5.69 0.33 3.43e-8 Neutrophil percentage of white cells; CESC cis rs2455799 0.613 rs2470538 chr3:15717124 G/C cg16303742 chr3:15540471 COLQ -0.39 -6.04 -0.35 5.27e-9 Mean platelet volume; CESC cis rs7264396 0.563 rs78084033 chr20:34219990 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.58 5.65 0.33 4.22e-8 Total cholesterol levels; CESC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg07870213 chr5:140052090 DND1 -0.62 -7.2 -0.4 6.04e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs1814175 0.626 rs1722008 chr11:49897676 A/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.89 -0.77 1.79e-54 Height; CESC cis rs9916302 0.904 rs8079303 chr17:37530755 G/C cg07936489 chr17:37558343 FBXL20 0.82 11.97 0.59 1.11e-26 Glomerular filtration rate (creatinine); CESC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg03188948 chr7:1209495 NA 0.71 6.85 0.39 5.21e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10089 1.000 rs4835941 chr5:127430905 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.19 0.53 8.58e-21 Ileal carcinoids; CESC cis rs1050631 0.592 rs1785900 chr18:33710170 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.56 7.87 0.44 9.26e-14 Esophageal squamous cell cancer (length of survival); CESC cis rs1355223 0.837 rs11600402 chr11:34691751 C/G cg11058730 chr11:34937778 PDHX;APIP -0.52 -6.67 -0.38 1.47e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9467711 0.606 rs34878490 chr6:26370572 C/T cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs6598955 0.543 rs12125620 chr1:26552238 G/A cg04990556 chr1:26633338 UBXN11 0.83 9.29 0.5 5.95e-18 Obesity-related traits; CESC cis rs2997447 0.723 rs61776623 chr1:26474490 A/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.63 5.44 0.32 1.2e-7 QRS complex (12-leadsum); CESC cis rs10791097 0.967 rs6590512 chr11:130717916 A/G cg12179176 chr11:130786555 SNX19 -0.51 -7.53 -0.42 7.87e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2204008 0.754 rs11181643 chr12:38380553 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.91 0.56 3.86e-23 Bladder cancer; CESC cis rs10883723 0.668 rs12414479 chr10:104420902 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.52 5.6 0.33 5.26e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg27286337 chr10:134555280 INPP5A 0.68 7.64 0.42 4.05e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2486288 0.656 rs1060896 chr15:45554267 C/A cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.56 -0.37 2.75e-10 Glomerular filtration rate; CESC cis rs9469578 0.636 rs16869463 chr6:33714983 A/G cg18708504 chr6:33715942 IP6K3 -0.61 -7.22 -0.41 5.49e-12 Phosphorus levels; CESC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg27121462 chr16:89883253 FANCA 0.75 10.62 0.55 3.59e-22 Vitiligo; CESC cis rs6546550 0.869 rs6720498 chr2:70124805 T/C cg02498382 chr2:70120550 SNRNP27 -0.4 -6.69 -0.38 1.34e-10 Prevalent atrial fibrillation; CESC cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.23e-9 Extrinsic epigenetic age acceleration; CESC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.53 -0.54 6.99e-22 Alzheimer's disease; CESC cis rs548181 0.604 rs11608103 chr11:125627917 G/A cg03464685 chr11:125439445 EI24 -0.61 -5.45 -0.32 1.14e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs17401966 0.838 rs946502 chr1:10309279 G/C cg15208524 chr1:10270712 KIF1B 0.4 5.21 0.31 3.73e-7 Hepatocellular carcinoma; CESC cis rs6981523 0.553 rs11989369 chr8:11055385 A/G cg21775007 chr8:11205619 TDH 0.41 5.22 0.31 3.69e-7 Neuroticism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16889839 chr12:132547279 EP400 0.43 6.06 0.35 4.58e-9 Fibrinogen levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00482248 chr7:73589137 EIF4H 0.47 6.43 0.37 6.07e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17039065 0.920 rs61327329 chr4:109447407 T/C cg16022748 chr4:109541635 LOC285456;RPL34 0.62 5.61 0.33 5.08e-8 Gut microbiome composition (summer); CESC cis rs11098499 0.645 rs72676059 chr4:120290828 C/G cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs9488822 0.676 rs873879 chr6:116391259 A/G cg05304507 chr6:116381966 FRK 0.26 6.84 0.39 5.58e-11 Cholesterol, total;LDL cholesterol; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10883266 chr13:100741297 PCCA -0.51 -6.66 -0.38 1.54e-10 Ulcerative colitis; CESC cis rs826838 0.935 rs1601579 chr12:39178606 G/C cg26384229 chr12:38710491 ALG10B 0.78 13.22 0.63 5.37e-31 Heart rate; CESC cis rs10911251 0.508 rs2245784 chr1:183107665 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.2 0.63 6.6e-31 Colorectal cancer; CESC cis rs3733585 0.578 rs4466042 chr4:9955367 T/C cg11266682 chr4:10021025 SLC2A9 -0.57 -10.92 -0.56 3.75e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6424115 0.830 rs1105 chr1:24200800 T/C cg10978503 chr1:24200527 CNR2 0.33 6.64 0.38 1.73e-10 Immature fraction of reticulocytes; CESC cis rs6582630 0.502 rs11614397 chr12:38328163 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.0 0.35 6.62e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7188697 0.922 rs8047769 chr16:58591987 G/A cg02549819 chr16:58548995 SETD6 0.43 5.38 0.31 1.61e-7 QT interval; CESC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.94 14.0 0.65 1.07e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6736093 0.931 rs7578435 chr2:112714751 G/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.46 -0.32 1.1e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11586124 chr12:58259160 NA 0.56 6.35 0.36 9.56e-10 Gut microbiome composition (summer); CESC cis rs7851660 0.809 rs7032114 chr9:100656459 T/G cg13688889 chr9:100608707 NA -0.62 -8.87 -0.48 1.11e-16 Strep throat; CESC cis rs1707322 0.686 rs1547924 chr1:46085112 C/T cg05343316 chr1:45956843 TESK2 0.52 6.34 0.36 9.89e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6141600 0.760 rs6060794 chr20:34682864 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.39 5.18 0.3 4.36e-7 Height;Hip circumference; CESC trans rs9388451 0.626 rs1739384 chr6:126099246 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.6 -8.17 -0.45 1.28e-14 Brugada syndrome; CESC cis rs8060686 0.668 rs2418739 chr16:68092850 G/C cg26727032 chr16:67993705 SLC12A4 -0.59 -8.17 -0.45 1.24e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs7945705 0.934 rs1988709 chr11:8882890 A/T cg09997546 chr11:8931473 C11orf17;ST5 0.35 5.64 0.33 4.29e-8 Hemoglobin concentration; CESC cis rs55692411 0.537 rs35012435 chr3:50031840 C/T cg24110177 chr3:50126178 RBM5 -0.44 -5.15 -0.3 5.03e-7 Intelligence (multi-trait analysis); CESC cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 13.31 0.63 2.64e-31 Platelet count; CESC cis rs5769765 0.818 rs8140681 chr22:50292081 C/A cg02269571 chr22:50332266 NA -0.45 -6.05 -0.35 4.98e-9 Schizophrenia; CESC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg25072359 chr17:41440525 NA 0.43 5.75 0.33 2.45e-8 Menopause (age at onset); CESC trans rs459571 1.000 rs456207 chr9:136911140 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.57 -7.48 -0.42 1.12e-12 Platelet distribution width; CESC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg10546459 chr2:36825355 FEZ2 0.5 6.03 0.35 5.58e-9 Height; CESC cis rs1348850 0.651 rs4893935 chr2:178240601 C/G cg23306229 chr2:178417860 TTC30B 0.5 6.48 0.37 4.4e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg18876405 chr7:65276391 NA 0.58 7.86 0.44 9.39e-14 Aortic root size; CESC cis rs6460942 0.597 rs7798779 chr7:12543490 A/G cg06484146 chr7:12443880 VWDE -0.71 -7.34 -0.41 2.66e-12 Coronary artery disease; CESC cis rs2070488 0.965 rs4679053 chr3:38523495 G/T cg24069376 chr3:38537580 EXOG 0.49 8.96 0.48 6.1e-17 Electrocardiographic conduction measures; CESC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.89 9.93 0.52 5.96e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs17641971 0.662 rs1858312 chr8:49996521 G/A cg00325661 chr8:49890786 NA 0.39 5.51 0.32 8.67e-8 Blood metabolite levels; CESC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg10541313 chr22:46663664 TTC38 0.67 5.9 0.34 1.1e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.54 0.37 3.13e-10 Bipolar disorder; CESC trans rs11720469 0.934 rs11714025 chr3:166500304 C/T cg03163944 chr19:37663716 ZNF585A -0.41 -6.05 -0.35 5.02e-9 Fast beta electroencephalogram; CESC cis rs727505 0.821 rs67167896 chr7:124614127 T/C cg23710748 chr7:124431027 NA -0.45 -7.08 -0.4 1.27e-11 Lewy body disease; CESC trans rs12339966 0.689 rs2252358 chr9:11677252 T/C cg03904639 chr13:37677730 CSNK1A1L 0.39 6.06 0.35 4.67e-9 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26602477 chr1:1476845 C1orf70 -0.59 -6.77 -0.38 8.37e-11 Gut microbiome composition (summer); CESC cis rs4474465 0.850 rs10899538 chr11:78237749 C/T cg27205649 chr11:78285834 NARS2 0.45 5.62 0.33 4.71e-8 Alzheimer's disease (survival time); CESC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.92 -0.59 1.68e-26 Alzheimer's disease; CESC cis rs5769765 0.865 rs10854860 chr22:50320029 G/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.62 -6.38 -0.37 7.75e-10 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19936194 chr3:141595256 ATP1B3 0.67 7.86 0.43 9.73e-14 Gut microbiome composition (summer); CESC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg27297192 chr10:134578999 INPP5A 0.4 5.37 0.31 1.7e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs896854 0.517 rs10112447 chr8:95955701 C/T cg09323728 chr8:95962352 TP53INP1 -0.35 -6.62 -0.38 1.93e-10 Type 2 diabetes; CESC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg02461776 chr11:598696 PHRF1 0.51 5.92 0.34 1.01e-8 Systemic lupus erythematosus; CESC cis rs7772486 0.790 rs2254283 chr6:146204289 T/C cg23711669 chr6:146136114 FBXO30 0.92 13.65 0.64 1.71e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs4803455 0.565 rs2241713 chr19:41869468 C/G cg08477640 chr19:41863820 B9D2 -0.51 -7.44 -0.42 1.42e-12 Migraine;Coronary artery disease; CESC cis rs74181299 0.890 rs2723062 chr2:65280220 G/A cg05010058 chr2:65284262 CEP68 0.33 5.66 0.33 3.89e-8 Pulse pressure; CESC cis rs12893668 0.663 rs12889731 chr14:104087482 C/T cg08213375 chr14:104286397 PPP1R13B 0.33 5.28 0.31 2.69e-7 Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02217955 chr22:50941799 LMF2 -0.49 -6.24 -0.36 1.68e-9 Gut microbiome composition (summer); CESC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.94 10.33 0.54 3.08e-21 Mean platelet volume; CESC cis rs2882667 1.000 rs2060222 chr5:138308466 C/T cg04439458 chr5:138467593 SIL1 -0.36 -5.68 -0.33 3.5e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs5753618 0.583 rs7285619 chr22:31842554 C/T cg13145458 chr22:31556086 RNF185 -0.5 -5.9 -0.34 1.11e-8 Colorectal cancer; CESC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg04369109 chr6:150039330 LATS1 -0.46 -6.46 -0.37 4.96e-10 Lung cancer; CESC cis rs2180341 0.824 rs9321076 chr6:127655614 G/A cg27446573 chr6:127587934 RNF146 1.09 16.35 0.71 5.12e-42 Breast cancer; CESC cis rs3015497 0.789 rs3015500 chr14:51108877 C/T cg09863266 chr14:51125203 SAV1 -0.35 -5.4 -0.31 1.46e-7 Mean platelet volume; CESC cis rs6445967 0.569 rs7622497 chr3:58282673 A/C cg23715586 chr3:58305044 RPP14 0.43 6.51 0.37 3.73e-10 Platelet count; CESC cis rs858239 0.632 rs13438452 chr7:23174182 A/G cg23682824 chr7:23144976 KLHL7 0.54 7.69 0.43 2.96e-13 Cerebrospinal fluid biomarker levels; CESC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg04287289 chr16:89883240 FANCA 0.91 15.37 0.69 1.51e-38 Vitiligo; CESC trans rs4332037 0.851 rs10268609 chr7:1962163 A/C cg11693508 chr17:37793320 STARD3 0.68 6.65 0.38 1.62e-10 Bipolar disorder; CESC cis rs1538970 0.739 rs4660863 chr1:45955868 T/C cg06784218 chr1:46089804 CCDC17 0.37 5.9 0.34 1.11e-8 Platelet count; CESC cis rs2251381 0.750 rs2776250 chr21:30528094 T/G cg08807101 chr21:30365312 RNF160 0.7 8.59 0.47 7.75e-16 Selective IgA deficiency; CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg16145915 chr7:1198662 ZFAND2A -0.78 -13.36 -0.63 1.82e-31 Longevity;Endometriosis; CESC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg15664640 chr17:80829946 TBCD 0.4 5.75 0.33 2.44e-8 Breast cancer; CESC cis rs4566357 1.000 rs2251223 chr2:227914975 T/G cg11843606 chr2:227700838 RHBDD1 -0.42 -5.28 -0.31 2.66e-7 Coronary artery disease; CESC cis rs2243480 1.000 rs4718315 chr7:65648541 T/C cg12463550 chr7:65579703 CRCP -0.73 -5.66 -0.33 4.03e-8 Diabetic kidney disease; CESC cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg25036284 chr2:26402008 FAM59B -0.61 -6.94 -0.39 3.08e-11 Gut microbiome composition (summer); CESC cis rs17253792 0.915 rs79894275 chr14:56180285 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.74 5.1 0.3 6.53e-7 Putamen volume; CESC cis rs3015497 0.603 rs2983420 chr14:51036950 T/C cg26011998 chr14:51135199 SAV1 0.49 5.45 0.32 1.16e-7 Mean platelet volume; CESC cis rs17253792 0.915 rs78498383 chr14:56177585 C/T cg01858014 chr14:56050164 KTN1 -0.91 -7.03 -0.4 1.8e-11 Putamen volume; CESC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg18876405 chr7:65276391 NA 0.48 6.31 0.36 1.16e-9 Aortic root size; CESC cis rs9487051 0.700 rs7773815 chr6:109602343 A/C cg12927641 chr6:109611667 NA -0.37 -5.62 -0.33 4.82e-8 Reticulocyte fraction of red cells; CESC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg25204440 chr1:209979598 IRF6 0.66 6.78 0.38 7.96e-11 Cleft lip with or without cleft palate; CESC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg19717773 chr7:2847554 GNA12 -0.53 -7.53 -0.42 7.94e-13 Height; CESC cis rs11098499 0.739 rs7441137 chr4:120133221 G/T cg09307838 chr4:120376055 NA -0.67 -8.37 -0.46 3.41e-15 Corneal astigmatism; CESC trans rs116095464 0.558 rs56298907 chr5:283280 C/A cg00938859 chr5:1591904 SDHAP3 0.72 6.62 0.38 2.04e-10 Breast cancer; CESC cis rs9888739 0.841 rs11864503 chr16:31331137 T/C cg15817542 chr16:31343056 ITGAM -0.42 -5.06 -0.3 7.71e-7 Systemic lupus erythematosus; CESC cis rs9660992 0.736 rs1180734 chr1:205255438 A/G cg19090574 chr1:205240910 TMCC2 -0.4 -5.47 -0.32 1.05e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs763121 0.853 rs2072796 chr22:39064230 A/G cg06544989 chr22:39130855 UNC84B 0.48 8.4 0.46 2.69e-15 Menopause (age at onset); CESC cis rs780096 0.587 rs4665969 chr2:27574953 C/T cg21248554 chr2:27665150 KRTCAP3 0.29 5.83 0.34 1.61e-8 Total body bone mineral density; CESC cis rs7208859 0.573 rs79505916 chr17:29062326 C/T cg14008862 chr17:28927542 LRRC37B2 0.66 5.21 0.3 3.75e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs117623576 0.941 rs211409 chr10:32393213 T/C cg03047570 chr10:32398778 NA 0.8 8.36 0.46 3.67e-15 Anti-saccade response; CESC trans rs10448044 0.750 rs9298326 chr8:80103395 G/A cg08211306 chr6:46097784 ENPP4 0.44 6.3 0.36 1.21e-9 Suicide in bipolar disorder; CESC cis rs7949030 0.588 rs2512563 chr11:62311249 C/G cg22862634 chr11:62369728 EML3;MTA2 0.49 6.83 0.39 5.97e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2859741 0.967 rs534131 chr1:37484237 T/C cg09363841 chr1:37513479 NA -0.64 -10.12 -0.53 1.46e-20 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs698833 0.538 rs1067396 chr2:44637738 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.38 0.31 1.62e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg10691866 chr7:65817282 TPST1 -0.34 -5.5 -0.32 8.73e-8 Aortic root size; CESC cis rs77861329 1.000 rs876782 chr3:52107909 C/T cg08692210 chr3:52188851 WDR51A -0.86 -8.23 -0.45 8.33e-15 Macrophage inflammatory protein 1b levels; CESC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg05896524 chr21:47604654 C21orf56 0.42 5.44 0.32 1.21e-7 Testicular germ cell tumor; CESC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.97 0.8 1.29e-61 Prudent dietary pattern; CESC cis rs4722166 0.695 rs7787893 chr7:22774437 A/G cg13104385 chr7:22767384 IL6 0.4 5.96 0.34 8.18e-9 Lung cancer; CESC cis rs12824058 0.831 rs12831363 chr12:130814013 C/T cg24838063 chr12:130822603 PIWIL1 -0.62 -8.54 -0.46 1.09e-15 Menopause (age at onset); CESC cis rs2795502 0.882 rs2744093 chr10:43339243 A/G cg27426351 chr10:43362370 NA -0.45 -5.5 -0.32 8.91e-8 Blood protein levels; CESC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg07636037 chr3:49044803 WDR6 0.72 11.51 0.58 3.92e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs754466 0.651 rs10824583 chr10:79619402 C/T cg17075019 chr10:79541650 NA 0.87 13.53 0.64 4.62e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg19717773 chr7:2847554 GNA12 -0.52 -7.77 -0.43 1.72e-13 Height; CESC cis rs34779708 0.931 rs72789690 chr10:35382817 T/C cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs10791097 0.765 rs7943757 chr11:130716157 C/T cg12179176 chr11:130786555 SNX19 0.54 7.78 0.43 1.65e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1048238 0.506 rs698890 chr1:16267371 C/G cg22431228 chr1:16359049 CLCNKA 0.38 6.64 0.38 1.81e-10 Systolic blood pressure; CESC cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs67478160 0.643 rs12434686 chr14:104316033 C/T cg01849466 chr14:104193079 ZFYVE21 0.5 6.92 0.39 3.46e-11 Schizophrenia; CESC cis rs6088590 0.561 rs6059918 chr20:33150503 C/T cg06115741 chr20:33292138 TP53INP2 0.51 6.4 0.37 7.09e-10 Coronary artery disease; CESC cis rs2404618 0.587 rs6994849 chr8:1492839 G/T cg02903104 chr8:1507517 DLGAP2 -0.32 -6.07 -0.35 4.53e-9 Lung cancer; CESC cis rs1950626 0.833 rs34463495 chr14:101411186 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.79 10.67 0.55 2.42e-22 Pelvic organ prolapse (moderate/severe); CESC cis rs9430161 0.645 rs6675082 chr1:11033797 T/C cg02454025 chr1:11042201 C1orf127 0.96 15.32 0.69 2.28e-38 Ewing sarcoma; CESC cis rs34779708 0.966 rs998658 chr10:35408654 A/G cg04310649 chr10:35416472 CREM -0.54 -6.47 -0.37 4.62e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs8040855 0.627 rs11631548 chr15:85619248 C/T cg08123816 chr15:85640762 PDE8A -0.4 -5.97 -0.34 7.56e-9 Bulimia nervosa; CESC cis rs933688 1.000 rs332529 chr5:90789470 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 9.93 0.52 5.99e-20 Smoking behavior; CESC cis rs73110464 0.609 rs6580923 chr12:53358352 A/G cg16329197 chr12:53359506 NA -0.7 -10.4 -0.54 1.84e-21 Cancer (pleiotropy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16678024 chr22:41996951 PPPDE2 -0.39 -6.53 -0.37 3.39e-10 Gambling; CESC trans rs61931739 0.534 rs10844840 chr12:34364517 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.2 0.36 2.16e-9 Morning vs. evening chronotype; CESC cis rs7843479 0.601 rs6557712 chr8:21826421 C/T cg17168535 chr8:21777572 XPO7 0.75 12.24 0.6 1.31e-27 Mean corpuscular volume; CESC cis rs2243480 1.000 rs958550 chr7:65635679 C/T cg12463550 chr7:65579703 CRCP -0.7 -5.39 -0.31 1.54e-7 Diabetic kidney disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03678139 chr1:41832388 NA 0.47 6.04 0.35 5.12e-9 Gut microbiota (bacterial taxa); CESC cis rs589448 0.934 rs554591 chr12:69753847 T/C cg22834771 chr12:69754056 YEATS4 -0.55 -7.21 -0.41 5.72e-12 Cerebrospinal fluid biomarker levels; CESC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.7 -8.29 -0.45 5.67e-15 Alzheimer's disease; CESC cis rs7267979 1.000 rs2258135 chr20:25272323 C/A cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.13e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs79349575 0.783 rs62075838 chr17:46996432 C/T cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs4481887 0.962 rs6663952 chr1:248465682 A/G cg00666640 chr1:248458726 OR2T12 0.39 6.31 0.36 1.19e-9 Common traits (Other); CESC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.13 0.81 3.58e-62 Prudent dietary pattern; CESC cis rs4911259 0.552 rs6058925 chr20:31465374 G/A cg13636640 chr20:31349939 DNMT3B -0.54 -7.47 -0.42 1.16e-12 Inflammatory bowel disease; CESC cis rs9399135 0.967 rs11754783 chr6:135347661 T/A cg22676075 chr6:135203613 NA 0.51 7.36 0.41 2.34e-12 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27452651 chr22:50312357 ALG12;CRELD2 0.67 7.8 0.43 1.42e-13 Gut microbiome composition (summer); CESC cis rs2932538 0.961 rs3795820 chr1:113163042 C/A cg22162597 chr1:113214053 CAPZA1 -0.6 -7.53 -0.42 7.76e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03929816 chr8:141231575 TRAPPC9 0.49 6.6 0.38 2.25e-10 Fibrinogen levels; CESC cis rs933688 1.000 rs10058025 chr5:90689052 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.87 0.59 2.36e-26 Smoking behavior; CESC cis rs938554 0.612 rs4385059 chr4:9989233 A/G cg00071950 chr4:10020882 SLC2A9 -0.58 -6.59 -0.38 2.4e-10 Blood metabolite levels; CESC cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7829975 0.511 rs1543238 chr8:8134809 A/G cg06636001 chr8:8085503 FLJ10661 0.63 7.76 0.43 1.83e-13 Mood instability; CESC cis rs2180341 1.000 rs2144742 chr6:127595786 C/A cg27446573 chr6:127587934 RNF146 1.07 15.98 0.7 1e-40 Breast cancer; CESC cis rs4919694 0.572 rs72846714 chr10:104878454 G/A cg04362960 chr10:104952993 NT5C2 0.63 6.25 0.36 1.66e-9 Arsenic metabolism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23943013 chr5:79551904 SERINC5 -0.46 -6.03 -0.35 5.58e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7949030 0.504 rs2516633 chr11:62371773 A/C cg13298116 chr11:62369859 EML3;MTA2 -0.5 -6.98 -0.39 2.37e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs10506458 0.834 rs73127067 chr12:63390333 G/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -17.85 -0.74 2.4e-47 Hemostatic factors and hematological phenotypes; CESC cis rs4889855 0.556 rs4890039 chr17:78517883 C/T cg16591659 chr17:78472290 NA 0.36 5.75 0.33 2.49e-8 Fractional excretion of uric acid; CESC cis rs7894051 1.000 rs7899476 chr10:135197214 A/G cg20534287 chr10:135191450 PAOX 0.66 5.33 0.31 2.12e-7 Lifespan; CESC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg08888203 chr3:10149979 C3orf24 0.49 6.14 0.35 3.07e-9 Alzheimer's disease; CESC cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4076764 1.000 rs6683181 chr1:163417077 C/T cg06092702 chr1:163392909 NA -0.39 -5.66 -0.33 3.88e-8 Motion sickness; CESC cis rs7296418 0.517 rs73231928 chr12:123724325 T/C cg05973401 chr12:123451056 ABCB9 0.49 6.36 0.36 8.72e-10 Platelet count; CESC cis rs6674176 0.696 rs4448553 chr1:44411589 A/G cg13606994 chr1:44402422 ARTN -0.38 -5.81 -0.34 1.82e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg03467027 chr4:99064603 C4orf37 0.48 5.93 0.34 9.5e-9 Colonoscopy-negative controls vs population controls; CESC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg16405210 chr4:1374714 KIAA1530 -0.96 -12.77 -0.62 2.05e-29 Longevity; CESC cis rs4803468 1.000 rs3213861 chr19:41919944 A/C cg09537434 chr19:41945824 ATP5SL -1.08 -18.9 -0.76 4.86e-51 Height; CESC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg14829155 chr15:31115871 NA 0.72 9.99 0.52 3.77e-20 Huntington's disease progression; CESC cis rs3820928 0.845 rs1917126 chr2:227840923 G/T cg11843606 chr2:227700838 RHBDD1 -0.44 -5.77 -0.33 2.22e-8 Pulmonary function; CESC cis rs151234 0.612 rs11641853 chr16:28589719 A/G cg01378222 chr16:28622494 SULT1A1 -0.57 -7.19 -0.4 6.43e-12 Platelet distribution width; CESC trans rs1908814 0.516 rs4841641 chr8:11798227 G/A cg15556689 chr8:8085844 FLJ10661 0.54 6.79 0.38 7.43e-11 Neuroticism; CESC cis rs7615952 0.688 rs7624806 chr3:125599074 G/A cg05084668 chr3:125655381 ALG1L -0.43 -5.05 -0.3 8.31e-7 Blood pressure (smoking interaction); CESC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg10253484 chr15:75165896 SCAMP2 -0.52 -6.9 -0.39 3.71e-11 Breast cancer; CESC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.67 0.38 1.48e-10 Bipolar disorder; CESC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg05332525 chr7:65337924 VKORC1L1 0.5 6.18 0.35 2.42e-9 Aortic root size; CESC cis rs6693567 0.545 rs6699093 chr1:150440451 A/G cg09579323 chr1:150459698 TARS2 -0.45 -5.77 -0.33 2.21e-8 Migraine; CESC cis rs1670533 1.000 rs6850784 chr4:1059809 G/A cg27284194 chr4:1044797 NA 0.47 6.07 0.35 4.4e-9 Recombination rate (females); CESC cis rs644799 0.930 rs2186782 chr11:95649543 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.42 5.13 0.3 5.57e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg20151795 chr6:28129481 ZNF389 0.41 5.3 0.31 2.46e-7 Depression; CESC cis rs4242434 0.757 rs7005025 chr8:22519815 G/T cg03733263 chr8:22462867 KIAA1967 0.73 10.67 0.55 2.4e-22 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs8072100 0.651 rs1912484 chr17:45443664 C/G cg08085267 chr17:45401833 C17orf57 -0.53 -6.65 -0.38 1.65e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs72781680 1.000 rs72798411 chr2:24184343 A/G cg20701182 chr2:24300061 SF3B14 0.79 6.83 0.39 5.75e-11 Lymphocyte counts; CESC cis rs6912958 0.781 rs9444524 chr6:88311260 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.68 -0.38 1.43e-10 Monocyte percentage of white cells; CESC cis rs2243480 1.000 rs1553174 chr7:65731194 T/C cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg24829409 chr8:58192753 C8orf71 -0.78 -10.18 -0.53 9.38e-21 Developmental language disorder (linguistic errors); CESC cis rs8014204 0.935 rs3742786 chr14:75373011 A/G cg08847533 chr14:75593920 NEK9 -0.46 -5.79 -0.34 1.96e-8 Caffeine consumption; CESC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg05564831 chr3:52568323 NT5DC2 0.48 7.57 0.42 6.08e-13 Electroencephalogram traits; CESC cis rs28830936 1.000 rs11070343 chr15:41940146 T/A cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.38 -5.48 -0.32 9.74e-8 Diastolic blood pressure; CESC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs34779708 0.931 rs7923172 chr10:35309367 G/A cg04310649 chr10:35416472 CREM -0.51 -6.27 -0.36 1.5e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs3733585 0.673 rs7434391 chr4:9967682 C/G cg02734326 chr4:10020555 SLC2A9 -0.39 -5.58 -0.32 5.96e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg07308232 chr7:1071921 C7orf50 -0.53 -7.42 -0.41 1.56e-12 Longevity;Endometriosis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25018755 chr22:43506952 BIK 0.54 7.42 0.41 1.59e-12 Systemic lupus erythematosus; CESC cis rs6121246 0.909 rs4518038 chr20:30419051 A/G cg13852791 chr20:30311386 BCL2L1 0.82 7.39 0.41 1.97e-12 Mean corpuscular hemoglobin; CESC cis rs7917772 0.582 rs7907417 chr10:104370662 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -5.73 -0.33 2.7e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9549260 0.753 rs1986649 chr13:41178824 C/T cg21288729 chr13:41239152 FOXO1 0.53 5.05 0.3 8.14e-7 Red blood cell count; CESC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.59 -0.32 5.57e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07870854 chr16:791252 NARFL 0.55 6.13 0.35 3.11e-9 Gut microbiome composition (summer); CESC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg24531977 chr5:56204891 C5orf35 -0.67 -9.25 -0.49 7.78e-18 Initial pursuit acceleration; CESC cis rs79349575 0.749 rs46521 chr17:46988529 A/G cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs10504073 0.669 rs818559 chr8:50035806 C/T cg00325661 chr8:49890786 NA 0.51 7.5 0.42 9.61e-13 Blood metabolite ratios; CESC cis rs67460515 0.892 rs73026974 chr3:160963231 A/C cg03342759 chr3:160939853 NMD3 -0.55 -7.79 -0.43 1.5e-13 Parkinson's disease; CESC cis rs6547741 1.000 rs6547741 chr2:27855924 G/A cg21248554 chr2:27665150 KRTCAP3 0.25 5.3 0.31 2.42e-7 Oral cavity cancer; CESC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg09509183 chr1:209979624 IRF6 0.56 5.81 0.34 1.82e-8 Cleft lip with or without cleft palate; CESC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 6.5 0.37 4.07e-10 LDL cholesterol;Cholesterol, total; CESC cis rs9611565 0.512 rs139571 chr22:42214238 G/A cg06634786 chr22:41940651 POLR3H -0.64 -6.23 -0.36 1.83e-9 Vitiligo; CESC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg12311346 chr5:56204834 C5orf35 -0.73 -8.67 -0.47 4.4e-16 Type 2 diabetes; CESC cis rs7904368 0.568 rs10752061 chr10:16853900 A/G cg23933602 chr10:16859644 RSU1 0.85 12.6 0.61 7.81e-29 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs78456975 1.000 rs4073861 chr2:1563611 G/A cg26248373 chr2:1572462 NA -0.53 -5.16 -0.3 4.89e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg18402987 chr7:1209562 NA 0.76 7.56 0.42 6.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10504545 chr14:74769802 ABCD4 -0.49 -6.21 -0.36 2.03e-9 Ulcerative colitis; CESC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg24562669 chr7:97807699 LMTK2 0.48 6.92 0.39 3.3e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs344364 0.511 rs911392 chr16:1947259 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.53 -6.19 -0.36 2.29e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -7.69 -0.43 2.89e-13 Tonsillectomy; CESC cis rs2742417 1.000 rs2742406 chr3:45760600 C/T cg10512202 chr3:45649293 LIMD1 0.35 5.03 0.3 9.01e-7 Response to anti-depressant treatment in major depressive disorder; CESC cis rs12973672 0.812 rs10421504 chr19:35764701 C/G cg12095397 chr19:35769544 USF2 0.49 5.81 0.34 1.77e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8141529 0.702 rs8137262 chr22:29292135 C/T cg02153584 chr22:29168773 CCDC117 0.59 7.62 0.42 4.46e-13 Lymphocyte counts; CESC cis rs1707322 0.752 rs11211169 chr1:46166709 A/G cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17826219 0.706 rs609472 chr17:28951427 T/C cg04154034 chr17:28927549 LRRC37B2 0.67 5.98 0.34 7.21e-9 Body mass index; CESC trans rs561341 1.000 rs550923 chr17:30327013 G/C cg20587970 chr11:113659929 NA -1.44 -18.71 -0.75 2.25e-50 Hip circumference adjusted for BMI; CESC cis rs7188697 0.922 rs40188 chr16:58567761 T/A cg21335942 chr16:58549945 SETD6 0.45 5.32 0.31 2.17e-7 QT interval; CESC cis rs9549367 0.789 rs12869947 chr13:113896156 A/G cg18105134 chr13:113819100 PROZ -0.67 -8.05 -0.44 2.82e-14 Platelet distribution width; CESC cis rs78366141 0.649 rs78114325 chr4:89682189 T/C cg01026744 chr4:89619053 NAP1L5;HERC3 0.79 5.63 0.33 4.5e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs4073582 0.595 rs801731 chr11:65938446 G/C cg14036092 chr11:66035641 RAB1B 0.54 7.52 0.42 8.55e-13 Gout; CESC cis rs11122272 0.766 rs2808614 chr1:231550168 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.58 7.93 0.44 5.95e-14 Hemoglobin concentration; CESC cis rs9640161 0.830 rs3757425 chr7:150067640 A/C cg10018233 chr7:150070692 REPIN1 0.49 8.94 0.48 6.79e-17 Blood protein levels;Circulating chemerin levels; CESC cis rs7809950 0.678 rs2237661 chr7:106863123 T/C cg23024343 chr7:107201750 COG5 -0.59 -7.11 -0.4 1.07e-11 Coronary artery disease; CESC cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -5.52 -0.32 8.01e-8 Personality dimensions; CESC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg07395648 chr5:131743802 NA -0.42 -5.41 -0.32 1.41e-7 Breast cancer;Mosquito bite size; CESC cis rs7107174 0.892 rs1567891 chr11:78101985 A/G cg02023728 chr11:77925099 USP35 0.47 6.3 0.36 1.24e-9 Testicular germ cell tumor; CESC trans rs66573146 0.831 rs1048009 chr4:6988677 G/A cg07817883 chr1:32538562 TMEM39B 1.04 7.45 0.42 1.34e-12 Granulocyte percentage of myeloid white cells; CESC cis rs6582630 0.502 rs11520276 chr12:38359216 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.02 0.35 5.87e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs10927875 1.000 rs4307563 chr1:16313788 C/T cg21385522 chr1:16154831 NA -0.77 -9.68 -0.51 3.51e-19 Dilated cardiomyopathy; CESC cis rs4812048 0.649 rs3761258 chr20:57618596 C/G cg14073986 chr20:57617431 SLMO2 -0.76 -6.38 -0.36 7.85e-10 Mean platelet volume; CESC cis rs7965445 0.892 rs115080397 chr12:131877059 A/G cg08164151 chr12:131118432 NA 0.62 5.38 0.31 1.6e-7 Mortality in heart failure; CESC cis rs727505 0.826 rs11532793 chr7:124747952 A/G cg23710748 chr7:124431027 NA -0.4 -6.36 -0.36 8.79e-10 Lewy body disease; CESC cis rs6951245 0.542 rs28460147 chr7:1217192 G/A cg24642844 chr7:1081250 C7orf50 -0.56 -6.81 -0.39 6.51e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2304069 0.954 rs216125 chr5:149428395 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.92 11.68 0.58 1.06e-25 HIV-1 control; CESC cis rs3617 0.573 rs3821873 chr3:52913006 C/T cg07507251 chr3:52567010 NT5DC2 -0.32 -5.39 -0.31 1.57e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs2243480 0.708 rs35310401 chr7:65390359 A/G cg13147721 chr7:65941812 NA -0.85 -8.1 -0.45 2e-14 Diabetic kidney disease; CESC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg24399712 chr22:39784796 NA -0.83 -10.31 -0.53 3.67e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs80130819 0.688 rs2732475 chr12:48700754 G/C cg05342945 chr12:48394962 COL2A1 -0.51 -5.6 -0.33 5.35e-8 Prostate cancer; CESC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg10883421 chr6:151773342 RMND1;C6orf211 -0.82 -13.34 -0.63 2.15e-31 Menarche (age at onset); CESC cis rs2075371 0.897 rs10488428 chr7:133997560 C/T cg20476274 chr7:133979776 SLC35B4 0.64 9.1 0.49 2.26e-17 Mean platelet volume; CESC cis rs6831352 0.693 rs2602875 chr4:100039495 C/G cg13256891 chr4:100009986 ADH5 0.69 8.13 0.45 1.61e-14 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12975330 chr19:53228974 ZNF611 -0.51 -5.99 -0.35 6.65e-9 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs576985 chr17:30323323 C/T cg23018236 chr17:30244563 NA -0.52 -5.11 -0.3 6.12e-7 Hip circumference adjusted for BMI; CESC cis rs1153858 1.000 rs2056493 chr15:45648272 A/G cg21132104 chr15:45694354 SPATA5L1 0.79 10.96 0.56 2.66e-23 Homoarginine levels; CESC trans rs1814175 0.645 rs1851869 chr11:49960552 T/C cg11707556 chr5:10655725 ANKRD33B -0.43 -6.24 -0.36 1.75e-9 Height; CESC cis rs117623576 0.941 rs111379000 chr10:32427247 A/G cg03047570 chr10:32398778 NA -0.57 -5.57 -0.32 6.11e-8 Anti-saccade response; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13921204 chr10:12171454 SEC61A2 0.58 6.75 0.38 9.51e-11 Gut microbiome composition (summer); CESC trans rs1814175 0.607 rs11493324 chr11:50011304 T/C cg03929089 chr4:120376271 NA -0.73 -9.4 -0.5 2.77e-18 Height; CESC cis rs7590368 0.640 rs12472302 chr2:10941301 G/A cg15705551 chr2:10952987 PDIA6 0.54 5.2 0.3 4.09e-7 Educational attainment (years of education); CESC cis rs507506 0.771 rs929229 chr17:7105399 C/T cg13729891 chr17:7108468 DLG4 -0.43 -5.35 -0.31 1.91e-7 Adiponectin levels; CESC cis rs7914558 0.966 rs1591915 chr10:104646849 C/T cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.27e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg04369109 chr6:150039330 LATS1 -0.44 -6.24 -0.36 1.7e-9 Lung cancer; CESC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg24818145 chr4:99064322 C4orf37 0.4 5.04 0.3 8.69e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.38 0.61 4.34e-28 Colonoscopy-negative controls vs population controls; CESC trans rs4129059 0.834 rs72759620 chr1:214684150 G/A cg08821431 chr12:34491090 NA 0.62 6.73 0.38 1.03e-10 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6430585 0.583 rs60253740 chr2:136571852 G/T cg07169764 chr2:136633963 MCM6 1.3 19.5 0.77 4.07e-53 Corneal structure; CESC cis rs11098499 0.863 rs7699064 chr4:120428309 A/G cg24375607 chr4:120327624 NA -0.43 -5.22 -0.31 3.68e-7 Corneal astigmatism; CESC cis rs116095464 0.558 rs9312957 chr5:202194 C/T cg16372103 chr5:203701 NA 0.49 5.49 0.32 9.48e-8 Breast cancer; CESC cis rs7605827 0.930 rs10189403 chr2:15635664 T/A cg19274914 chr2:15703543 NA 0.36 6.32 0.36 1.09e-9 Educational attainment (years of education); CESC cis rs4975616 0.804 rs457130 chr5:1336178 A/T cg26373071 chr5:1325741 CLPTM1L 0.44 6.94 0.39 2.94e-11 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23323388 chr11:6502596 FXC1;ARFIP2 0.55 6.06 0.35 4.58e-9 Gut microbiome composition (summer); CESC cis rs7927771 1.000 rs12418852 chr11:47868853 C/G cg18512352 chr11:47633146 NA -0.6 -9.47 -0.5 1.62e-18 Subjective well-being; CESC cis rs1395 0.710 rs72817533 chr2:27482612 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 5.48 0.32 9.82e-8 Blood metabolite levels; CESC cis rs9303280 0.806 rs10852935 chr17:38031674 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.42 -0.32 1.34e-7 Self-reported allergy; CESC cis rs10504229 0.516 rs11781671 chr8:57992733 T/C cg22535103 chr8:58192502 C8orf71 -0.48 -5.89 -0.34 1.16e-8 Developmental language disorder (linguistic errors); CESC cis rs727505 1.000 rs10240673 chr7:124513050 A/G cg23710748 chr7:124431027 NA -0.47 -7.43 -0.42 1.46e-12 Lewy body disease; CESC cis rs12410462 0.582 rs12408978 chr1:227596235 A/T cg04117972 chr1:227635322 NA -0.73 -6.88 -0.39 4.18e-11 Major depressive disorder; CESC cis rs4588572 0.686 rs10078289 chr5:77670793 T/G cg11547950 chr5:77652471 NA 0.45 5.76 0.33 2.37e-8 Triglycerides; CESC cis rs863345 0.604 rs7549581 chr1:158489704 T/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC cis rs6032067 0.929 rs2233883 chr20:43835822 T/C cg11264863 chr20:43835661 SEMG1 0.48 5.26 0.31 2.99e-7 Blood protein levels; CESC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg25985355 chr7:65971099 NA 0.32 5.29 0.31 2.51e-7 Aortic root size; CESC cis rs2735413 0.918 rs36068555 chr16:78077082 G/A cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs9611519 1.000 rs9611520 chr22:41613303 C/T cg03806693 chr22:41940476 POLR3H -0.62 -6.45 -0.37 5.16e-10 Neuroticism; CESC cis rs6831352 0.918 rs28987097 chr4:100049579 C/T cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs10870270 1.000 rs7077744 chr10:133770201 C/T cg17892150 chr10:133769511 PPP2R2D -0.86 -12.56 -0.61 1.08e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs6964587 1.000 rs1063243 chr7:91726927 A/C cg17063962 chr7:91808500 NA 0.55 7.6 0.42 5e-13 Breast cancer; CESC cis rs7208859 0.573 rs11656278 chr17:29075188 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1707322 0.721 rs4415615 chr1:46132109 C/T cg05343316 chr1:45956843 TESK2 0.51 6.24 0.36 1.7e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4803468 1.000 rs284651 chr19:41928336 T/C cg14132834 chr19:41945861 ATP5SL -0.66 -8.15 -0.45 1.46e-14 Height; CESC cis rs55788414 0.860 rs28697180 chr16:81185079 C/T cg06400318 chr16:81190750 PKD1L2 -0.6 -6.82 -0.39 6.19e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs2243480 1.000 rs781142 chr7:65438778 C/T cg18252515 chr7:66147081 NA -1.08 -10.48 -0.54 9.71e-22 Diabetic kidney disease; CESC cis rs10242455 0.557 rs2404487 chr7:99038057 G/A cg18809830 chr7:99032528 PTCD1 -0.63 -5.13 -0.3 5.68e-7 Blood metabolite levels; CESC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.28 0.31 2.75e-7 Menopause (age at onset); CESC cis rs1514687 0.534 rs73911839 chr2:1475088 C/T cg13703866 chr2:1479523 TPO -0.79 -5.36 -0.31 1.81e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs7520050 0.743 rs61789988 chr1:46085242 G/C cg24296786 chr1:45957014 TESK2 0.44 5.58 0.32 5.88e-8 Red blood cell count;Reticulocyte count; CESC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs2549003 1.000 rs6873426 chr5:131818631 G/T cg02551604 chr5:131831745 NA -0.37 -5.23 -0.31 3.45e-7 Asthma (sex interaction); CESC cis rs6060717 0.610 rs2794383 chr20:34615152 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -7.86 -0.43 9.46e-14 Hip circumference adjusted for BMI; CESC cis rs28374715 0.532 rs316606 chr15:41772202 A/C cg18705301 chr15:41695430 NDUFAF1 -1.08 -17.26 -0.73 2.91e-45 Ulcerative colitis; CESC cis rs2735413 0.875 rs4888736 chr16:78083784 T/C cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.37 -0.54 2.25e-21 Alzheimer's disease; CESC cis rs9549367 0.713 rs9549356 chr13:113851633 A/G cg18105134 chr13:113819100 PROZ -0.7 -8.26 -0.45 6.89e-15 Platelet distribution width; CESC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg08859206 chr1:53392774 SCP2 0.54 6.88 0.39 4.29e-11 Monocyte count; CESC cis rs2204008 0.818 rs1589389 chr12:38416041 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.34 -0.5 4.08e-18 Bladder cancer; CESC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg06873352 chr17:61820015 STRADA 0.72 12.91 0.62 6.56e-30 Prudent dietary pattern; CESC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -6.69 -0.38 1.36e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11855759 chr17:9548802 USP43 0.59 6.85 0.39 5.05e-11 Gut microbiome composition (summer); CESC trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.35 -0.46 3.8e-15 Intelligence (multi-trait analysis); CESC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.05 11.23 0.57 3.43e-24 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg26338869 chr17:61819248 STRADA 0.67 8.77 0.47 2.24e-16 Prudent dietary pattern; CESC cis rs12410462 1.000 rs75360545 chr1:227625419 T/C cg23173402 chr1:227635558 NA 0.57 5.92 0.34 9.9e-9 Major depressive disorder; CESC trans rs11098499 0.909 rs79026312 chr4:120440677 C/A cg25214090 chr10:38739885 LOC399744 0.71 9.72 0.51 2.74e-19 Corneal astigmatism; CESC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg02788857 chr8:22132959 PIWIL2 0.32 5.59 0.32 5.6e-8 Hypertriglyceridemia; CESC cis rs2439831 0.867 rs11856184 chr15:43919162 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.71 8.69 0.47 3.81e-16 Lung cancer in ever smokers; CESC cis rs6032067 0.929 rs13039213 chr20:43805712 A/C cg10761708 chr20:43804764 PI3 0.53 6.33 0.36 1.04e-9 Blood protein levels; CESC cis rs668210 0.894 rs1786171 chr11:65769809 G/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.74 9.4 0.5 2.64e-18 Cerebrospinal fluid biomarker levels; CESC cis rs7680126 0.530 rs2903827 chr4:10175872 C/G cg11266682 chr4:10021025 SLC2A9 -0.46 -6.18 -0.36 2.38e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg18876405 chr7:65276391 NA -0.5 -6.9 -0.39 3.87e-11 Aortic root size; CESC cis rs561341 0.941 rs112569713 chr17:30271738 C/T cg12193833 chr17:30244370 NA -0.62 -6.33 -0.36 1.06e-9 Hip circumference adjusted for BMI; CESC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg25036284 chr2:26402008 FAM59B 0.82 8.69 0.47 3.88e-16 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01971940 chr16:1259322 CACNA1H -0.44 -6.02 -0.35 5.89e-9 Gut microbiome composition (summer); CESC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg11890956 chr21:40555474 PSMG1 -1.16 -23.2 -0.82 9.1e-66 Cognitive function; CESC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.48 0.32 9.89e-8 Bipolar disorder; CESC cis rs6502050 0.787 rs7222326 chr17:80057272 T/C cg23985595 chr17:80112537 CCDC57 0.4 6.05 0.35 4.99e-9 Life satisfaction; CESC cis rs13191362 0.935 rs34035978 chr6:163165336 G/C cg06582575 chr6:163149167 PACRG;PARK2 0.67 7.11 0.4 1.05e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3106136 0.934 rs35995707 chr4:95167150 C/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.94 -0.39 3.02e-11 Capecitabine sensitivity; CESC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg26354017 chr1:205819088 PM20D1 0.49 6.99 0.39 2.27e-11 Menarche (age at onset); CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg18765753 chr7:1198926 ZFAND2A -0.58 -8.93 -0.48 7.28e-17 Longevity;Endometriosis; CESC cis rs6963495 0.818 rs6973974 chr7:105170629 C/T cg13798780 chr7:105162888 PUS7 0.77 7.88 0.44 8.3e-14 Bipolar disorder (body mass index interaction); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg24004055 chr6:25279718 LRRC16A -0.45 -6.11 -0.35 3.49e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs11098499 1.000 rs13116504 chr4:120209412 A/C cg24375607 chr4:120327624 NA 0.42 5.04 0.3 8.8e-7 Corneal astigmatism; CESC cis rs9814567 0.806 rs7626557 chr3:134318213 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.38 -5.05 -0.3 8.34e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4563143 0.675 rs55849754 chr19:29279665 G/A cg04546413 chr19:29218101 NA 0.54 7.17 0.4 7.28e-12 Methadone dose in opioid dependence; CESC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg23590916 chr17:43697445 MGC57346 0.65 6.58 0.37 2.51e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs79976124 0.797 rs74995761 chr6:66640216 G/A cg07460842 chr6:66804631 NA 0.72 8.37 0.46 3.35e-15 Type 2 diabetes; CESC cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg03676636 chr4:99064102 C4orf37 0.36 5.42 0.32 1.35e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2479724 0.935 rs2025951 chr6:41827193 C/T cg08135965 chr6:41755394 TOMM6 -0.39 -5.37 -0.31 1.7e-7 Menarche (age at onset); CESC cis rs941408 0.515 rs759067 chr19:2775668 C/T cg06609049 chr19:2785107 THOP1 0.96 14.63 0.67 6.13e-36 Total cholesterol levels; CESC cis rs2777491 1.000 rs7177641 chr15:41743426 C/T cg20272979 chr15:41787780 ITPKA 0.46 6.87 0.39 4.62e-11 Ulcerative colitis; CESC cis rs9908102 0.740 rs58854608 chr17:12904540 C/T cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs34638657 0.702 rs11866709 chr16:82201017 A/G cg09439754 chr16:82129088 HSD17B2 -0.36 -6.24 -0.36 1.71e-9 Lung adenocarcinoma; CESC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.71 0.33 3.07e-8 Depression; CESC cis rs870825 0.616 rs10006828 chr4:185651416 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.74e-11 Blood protein levels; CESC cis rs722599 0.683 rs2058918 chr14:75288518 A/G cg08847533 chr14:75593920 NEK9 0.5 5.97 0.34 7.71e-9 IgG glycosylation; CESC cis rs863345 0.604 rs1894038 chr1:158455947 T/C cg12129480 chr1:158549410 OR10X1 -0.36 -7.14 -0.4 8.77e-12 Pneumococcal bacteremia; CESC cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.6 -8.71 -0.47 3.35e-16 Personality dimensions; CESC trans rs7980799 0.711 rs12319055 chr12:33626509 C/T cg26384229 chr12:38710491 ALG10B -0.55 -7.81 -0.43 1.32e-13 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg11764359 chr7:65958608 NA 0.66 8.46 0.46 1.78e-15 Calcium levels; CESC cis rs11750568 0.967 rs6864279 chr5:178515060 G/T cg10208897 chr5:178548229 ADAMTS2 -0.38 -5.44 -0.32 1.24e-7 Height; CESC cis rs9911578 0.967 rs1588322 chr17:56990099 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.81 -0.39 6.5500000000000006e-11 Intelligence (multi-trait analysis); CESC cis rs8099014 0.814 rs7227488 chr18:56113233 A/G cg19312305 chr18:56117016 MIR122 -0.26 -5.17 -0.3 4.51e-7 Platelet count; CESC cis rs7818345 0.967 rs17479099 chr8:19277144 T/C cg11303988 chr8:19266685 CSGALNACT1 0.32 5.84 0.34 1.56e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs1538970 0.924 rs7531253 chr1:45890183 T/C cg05343316 chr1:45956843 TESK2 0.89 12.41 0.61 3.59e-28 Platelet count; CESC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg18032046 chr6:28092343 ZSCAN16 -0.6 -6.84 -0.39 5.51e-11 Depression; CESC cis rs28374715 0.528 rs7181982 chr15:41623020 C/G cg20272979 chr15:41787780 ITPKA 0.47 5.58 0.32 5.94e-8 Ulcerative colitis; CESC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg26335602 chr6:28129616 ZNF389 0.54 7.3 0.41 3.37e-12 Depression; CESC cis rs57506017 0.561 rs3800847 chr7:12262242 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.51e-7 Neuroticism; CESC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg02427764 chr11:65769310 BANF1;EIF1AD -0.44 -5.12 -0.3 6.02e-7 Breast cancer; CESC cis rs711245 0.574 rs1179494 chr2:36809496 C/G cg01206211 chr2:36825736 FEZ2 -0.33 -5.75 -0.33 2.39e-8 Height; CESC cis rs9488822 0.676 rs11153594 chr6:116354591 A/G cg05304507 chr6:116381966 FRK -0.26 -6.75 -0.38 9.16e-11 Cholesterol, total;LDL cholesterol; CESC cis rs250677 0.522 rs62378210 chr5:148384885 G/A cg18129178 chr5:148520854 ABLIM3 -0.46 -5.14 -0.3 5.32e-7 Breast cancer; CESC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg02569458 chr12:86230093 RASSF9 0.5 7.71 0.43 2.53e-13 Major depressive disorder; CESC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg24675658 chr1:53192096 ZYG11B -0.63 -7.68 -0.43 3.03e-13 Monocyte count; CESC cis rs6964587 1.000 rs2961020 chr7:91573308 G/A cg17063962 chr7:91808500 NA -0.54 -7.12 -0.4 9.86e-12 Breast cancer; CESC cis rs8060686 0.641 rs7190079 chr16:68073834 G/A cg26727032 chr16:67993705 SLC12A4 -0.54 -6.21 -0.36 2.01e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs9291683 0.620 rs4383618 chr4:10125151 T/C cg11266682 chr4:10021025 SLC2A9 -0.48 -8.68 -0.47 4.01e-16 Bone mineral density; CESC cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg20503657 chr10:835505 NA 0.69 6.31 0.36 1.19e-9 Eosinophil percentage of granulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09920427 chr19:12777674 MORG1;MAN2B1 0.52 6.82 0.39 6.05e-11 Gut microbiota (bacterial taxa); CESC cis rs8077889 0.703 rs231531 chr17:41946180 A/C cg26893861 chr17:41843967 DUSP3 0.66 6.92 0.39 3.43e-11 Triglycerides; CESC cis rs9811920 0.695 rs1287284 chr3:99516962 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.43 -7.03 -0.4 1.72e-11 Axial length; CESC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg06456125 chr7:65229604 NA 0.41 5.26 0.31 2.99e-7 Aortic root size; CESC cis rs734999 0.588 rs4648652 chr1:2535758 A/G cg18854424 chr1:2615690 NA 0.28 5.64 0.33 4.44e-8 Ulcerative colitis; CESC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.04 -0.56 1.41e-23 Alzheimer's disease; CESC cis rs6964587 1.000 rs6956596 chr7:91750107 T/G cg17063962 chr7:91808500 NA 0.53 7.14 0.4 9.24e-12 Breast cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg27426340 chr1:11589839 PTCHD2 -0.37 -6.39 -0.37 7.33e-10 Systemic lupus erythematosus; CESC cis rs2742234 0.541 rs7098236 chr10:43740508 T/C cg15436174 chr10:43711423 RASGEF1A 0.46 5.3 0.31 2.44e-7 Hirschsprung disease; CESC cis rs2576037 0.796 rs2576038 chr18:44582200 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.61 -8.73 -0.47 2.87e-16 Personality dimensions; CESC cis rs11792861 0.781 rs2297581 chr9:111755008 C/T cg05043794 chr9:111880884 C9orf5 -0.38 -6.26 -0.36 1.54e-9 Menarche (age at onset); CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg24846343 chr22:24311635 DDTL 0.63 10.51 0.54 7.74e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs208520 0.661 rs851466 chr6:66840476 A/G cg07460842 chr6:66804631 NA -0.99 -13.42 -0.64 1.15e-31 Exhaled nitric oxide output; CESC cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg26597838 chr10:835615 NA 0.71 8.15 0.45 1.43e-14 Eosinophil percentage of granulocytes; CESC cis rs6121246 0.567 rs6060260 chr20:30192907 C/T cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs12780046 0.536 rs12268360 chr10:101013466 C/G cg27143070 chr10:101087766 CNNM1 0.38 5.62 0.33 4.74e-8 Non-glioblastoma glioma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18048544 chr8:38033938 LSM1;BAG4 0.75 8.15 0.45 1.48e-14 Gut microbiome composition (summer); CESC cis rs3540 0.597 rs1978150 chr15:91037041 A/G cg22089800 chr15:90895588 ZNF774 -0.65 -8.92 -0.48 7.99e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs75804782 0.521 rs72994973 chr2:239428315 C/T cg18131467 chr2:239335373 ASB1 -0.68 -5.18 -0.3 4.38e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs10751667 0.714 rs7396700 chr11:963863 A/C cg01483505 chr11:975446 AP2A2 0.36 5.05 0.3 8.13e-7 Alzheimer's disease (late onset); CESC cis rs830124 0.602 rs686220 chr12:122386515 A/G cg22168489 chr12:122356033 WDR66 -0.38 -5.05 -0.3 8.27e-7 Urinary metabolites; CESC cis rs61931739 0.534 rs7965503 chr12:34199349 A/G cg19457237 chr12:34500585 NA -0.4 -5.42 -0.32 1.32e-7 Morning vs. evening chronotype; CESC cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg08564027 chr20:61660810 NA 0.9 15.37 0.69 1.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.546 rs9993299 chr4:98815976 G/A cg05340658 chr4:99064831 C4orf37 0.54 6.35 0.36 9.22e-10 Colonoscopy-negative controls vs population controls; CESC cis rs9325144 0.647 rs34311455 chr12:39060889 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.23 -0.41 5.23e-12 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09311052 chr1:154531418 UBE2Q1 -0.42 -6.17 -0.35 2.58e-9 Gambling; CESC cis rs3820068 0.603 rs1122387 chr1:15947282 T/C cg17385448 chr1:15911702 AGMAT 0.42 6.83 0.39 5.64e-11 Systolic blood pressure; CESC cis rs10979 1.000 rs13198159 chr6:143891953 C/T cg25407410 chr6:143891975 LOC285740 -0.62 -9.3 -0.5 5.3e-18 Hypospadias; CESC cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg22800045 chr5:56110881 MAP3K1 -0.61 -7.83 -0.43 1.21e-13 Initial pursuit acceleration; CESC cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg16339924 chr4:17578868 LAP3 0.54 6.64 0.38 1.76e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.15e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504073 0.584 rs62507210 chr8:49946601 C/T cg00325661 chr8:49890786 NA 0.58 8.75 0.47 2.59e-16 Blood metabolite ratios; CESC cis rs1577917 1.000 rs2324843 chr6:86617501 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.22 -0.36 1.9e-9 Response to antipsychotic treatment; CESC cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg03060546 chr3:49711283 APEH 0.52 6.31 0.36 1.17e-9 Parkinson's disease; CESC cis rs7100689 0.622 rs1340383 chr10:82095968 T/G cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 5.06e-14 Post bronchodilator FEV1; CESC cis rs561341 1.000 rs560132 chr17:30320019 C/T cg19193384 chr17:30244184 NA -0.71 -6.63 -0.38 1.85e-10 Hip circumference adjusted for BMI; CESC trans rs709082 0.771 rs796627 chr3:191455386 T/G cg25305879 chr2:106814630 NA 0.4 6.33 0.36 1.03e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg03647317 chr4:187891568 NA -0.39 -5.76 -0.33 2.37e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7560272 0.501 rs7210 chr2:73957124 A/G cg20560298 chr2:73613845 ALMS1 0.43 5.86 0.34 1.4e-8 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14751398 chr6:20402153 E2F3 0.51 6.59 0.38 2.37e-10 Gut microbiota (bacterial taxa); CESC cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg11812906 chr14:75593930 NEK9 0.73 11.2 0.57 4.15e-24 Height; CESC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg03934478 chr11:495069 RNH1 0.56 5.36 0.31 1.77e-7 Body mass index; CESC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg24562669 chr7:97807699 LMTK2 0.52 7.75 0.43 1.91e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg20307385 chr11:47447363 PSMC3 0.69 8.91 0.48 8.43e-17 Subjective well-being; CESC cis rs12410462 0.579 rs77529417 chr1:227547895 T/C cg10327440 chr1:227177885 CDC42BPA -0.68 -5.74 -0.33 2.56e-8 Major depressive disorder; CESC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.61 8.0 0.44 3.91e-14 Menopause (age at onset); CESC cis rs6570726 0.935 rs422540 chr6:145837815 G/T cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs614226 0.938 rs7972244 chr12:120994872 A/G cg01236616 chr12:121019343 POP5 1.5 18.76 0.76 1.47e-50 Type 1 diabetes nephropathy; CESC cis rs2204008 0.582 rs11179135 chr12:38204689 A/C cg26384229 chr12:38710491 ALG10B 0.73 10.16 0.53 1.08e-20 Bladder cancer; CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg04622731 chr7:157956161 PTPRN2 -0.5 -7.42 -0.41 1.63e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs8141529 0.764 rs8137969 chr22:29228484 G/C cg02153584 chr22:29168773 CCDC117 0.64 9.16 0.49 1.46e-17 Lymphocyte counts; CESC cis rs1270639 0.778 rs2530404 chr7:157445995 C/T cg13357408 chr7:157437802 PTPRN2 -0.61 -7.15 -0.4 8.33e-12 Colorectal cancer; CESC cis rs4253772 0.550 rs9615913 chr22:46668515 A/T cg10231785 chr22:46692440 CN5H6.4;GTSE1 -0.56 -6.02 -0.35 5.77e-9 LDL cholesterol;Cholesterol, total; CESC cis rs3820928 0.874 rs13403281 chr2:227880769 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -5.71 -0.33 2.95e-8 Pulmonary function; CESC cis rs11098499 0.863 rs10013305 chr4:120450424 G/A cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs2408955 0.522 rs3997 chr12:48481587 T/C cg24011408 chr12:48396354 COL2A1 -0.5 -7.48 -0.42 1.11e-12 Glycated hemoglobin levels; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08163220 chr3:31574309 STT3B 0.48 6.87 0.39 4.61e-11 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.4 0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg08027265 chr7:2291960 NA -0.39 -6.18 -0.35 2.46e-9 Schizophrenia; CESC cis rs9287719 0.837 rs4233883 chr2:10755596 A/G cg02196655 chr2:10830764 NOL10 -0.36 -5.44 -0.32 1.24e-7 Prostate cancer; CESC cis rs17021463 0.673 rs35898424 chr4:95289278 A/G cg11021082 chr4:95130006 SMARCAD1 0.51 6.98 0.39 2.32e-11 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg25767906 chr1:53392781 SCP2 -0.44 -5.61 -0.33 4.98e-8 Monocyte count; CESC cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.86 0.59 2.7e-26 Smoking behavior; CESC cis rs644799 1.000 rs494829 chr11:95571750 C/A cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.53 0.37 3.39e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg17971929 chr21:40555470 PSMG1 1.03 15.85 0.7 2.92e-40 Cognitive function; CESC cis rs10129255 0.833 rs61997797 chr14:107223423 G/A cg23076370 chr14:107095027 NA -0.44 -5.18 -0.3 4.3e-7 Kawasaki disease; CESC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg17143192 chr8:8559678 CLDN23 0.75 8.97 0.48 5.42e-17 Obesity-related traits; CESC cis rs9549367 0.713 rs9577211 chr13:113830718 G/C cg18105134 chr13:113819100 PROZ -0.65 -8.26 -0.45 7.1e-15 Platelet distribution width; CESC cis rs854765 0.964 rs12943202 chr17:17994332 T/A cg09796270 chr17:17721594 SREBF1 -0.37 -5.08 -0.3 7.17e-7 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06875660 chr1:85040134 CTBS 0.64 7.18 0.4 6.9e-12 Gut microbiome composition (summer); CESC cis rs425277 1.000 rs385039 chr1:2077409 C/T cg24578937 chr1:2090814 PRKCZ -0.54 -9.49 -0.5 1.36e-18 Height; CESC cis rs11098499 0.738 rs34965784 chr4:120361586 G/C cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg07701084 chr6:150067640 NUP43 0.44 5.95 0.34 8.4e-9 Lung cancer; CESC cis rs4919687 0.679 rs12762176 chr10:104499232 A/T cg04362960 chr10:104952993 NT5C2 0.45 5.21 0.3 3.88e-7 Colorectal cancer; CESC cis rs12410462 0.581 rs113827839 chr1:227547180 C/T cg10327440 chr1:227177885 CDC42BPA -0.68 -5.74 -0.33 2.56e-8 Major depressive disorder; CESC cis rs1065852 0.526 rs7290655 chr22:42390225 C/G cg22189786 chr22:42395067 WBP2NL 0.44 5.5 0.32 8.77e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26804944 chr12:56660921 COQ10A -0.48 -6.51 -0.37 3.65e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -6.7 -0.38 1.24e-10 Developmental language disorder (linguistic errors); CESC cis rs9549367 0.713 rs576463 chr13:113846614 C/T cg00898013 chr13:113819073 PROZ 0.46 6.8 0.39 7.09e-11 Platelet distribution width; CESC trans rs1545843 0.564 rs2468287 chr12:84888498 G/A cg03015433 chr16:56623111 MT3 0.34 6.13 0.35 3.18e-9 Major depressive disorder; CESC cis rs1670533 1.000 rs676561 chr4:1083112 C/T cg04106633 chr4:1044584 NA 0.4 5.1 0.3 6.33e-7 Recombination rate (females); CESC cis rs977987 0.806 rs11644306 chr16:75490053 T/C cg03315344 chr16:75512273 CHST6 0.46 6.72 0.38 1.09e-10 Dupuytren's disease; CESC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.39 5.14 0.3 5.23e-7 Bipolar disorder; CESC cis rs1728785 0.901 rs6499186 chr16:68660565 C/T cg02972257 chr16:68554789 NA -0.66 -6.89 -0.39 4.06e-11 Ulcerative colitis; CESC cis rs17539620 0.624 rs62432736 chr6:154834401 A/G cg17771515 chr6:154831774 CNKSR3 0.6 6.0 0.35 6.52e-9 Lipoprotein (a) levels; CESC cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg11752832 chr7:134001865 SLC35B4 0.51 6.52 0.37 3.54e-10 Mean platelet volume; CESC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg17414380 chr19:19431394 KIAA0892;SF4 0.46 5.86 0.34 1.35e-8 Tonsillectomy; CESC cis rs854765 0.583 rs4925123 chr17:17784374 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.48 -6.65 -0.38 1.71e-10 Total body bone mineral density; CESC cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg05347473 chr6:146136440 FBXO30 0.63 8.02 0.44 3.46e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs2066819 1.000 rs79718165 chr12:56644251 C/T cg26734620 chr12:56694298 CS 1.04 6.73 0.38 1.06e-10 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19246266 chr1:68697366 GPR177 -0.6 -7.21 -0.4 6.02e-12 Gut microbiome composition (summer); CESC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg22963979 chr7:1858916 MAD1L1 -0.43 -5.88 -0.34 1.25e-8 Bipolar disorder and schizophrenia; CESC cis rs17376456 0.877 rs10060160 chr5:93387879 G/A cg21475434 chr5:93447410 FAM172A 0.84 7.13 0.4 9.45e-12 Diabetic retinopathy; CESC cis rs6062302 0.522 rs3761126 chr20:62252044 C/T cg09650180 chr20:62225654 GMEB2 -0.82 -9.36 -0.5 3.43e-18 Glioblastoma; CESC cis rs9486719 0.948 rs2092095 chr6:96870864 T/G cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs7914558 0.966 rs10748839 chr10:104953547 A/G cg04362960 chr10:104952993 NT5C2 0.47 6.26 0.36 1.56e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg02297831 chr4:17616191 MED28 0.49 6.15 0.35 2.81e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2243480 1.000 rs2707844 chr7:66059509 G/A cg12463550 chr7:65579703 CRCP 0.74 5.83 0.34 1.61e-8 Diabetic kidney disease; CESC cis rs10779751 0.770 rs2486922 chr1:11124885 T/C cg08854313 chr1:11322531 MTOR 0.77 10.41 0.54 1.73e-21 Body mass index; CESC cis rs6500395 0.962 rs9937623 chr16:48571590 A/T cg04672837 chr16:48644449 N4BP1 -0.47 -5.61 -0.33 5.17e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6701037 1.000 rs6659824 chr1:175125378 C/A cg00321850 chr1:175162397 KIAA0040 -0.42 -5.88 -0.34 1.22e-8 Alcohol dependence; CESC cis rs8114671 0.562 rs34837802 chr20:33424908 C/G cg07148914 chr20:33460835 GGT7 0.43 5.7 0.33 3.27e-8 Height; CESC cis rs6011002 1.000 rs79391682 chr20:62297768 A/G cg15212369 chr20:62274085 STMN3 -0.57 -5.16 -0.3 4.82e-7 Dental caries; CESC cis rs360798 0.512 rs2710640 chr2:63144305 A/G cg17519650 chr2:63277830 OTX1 0.54 7.04 0.4 1.66e-11 Coronary artery disease; CESC cis rs9905704 0.633 rs2680712 chr17:56509865 C/T cg12560992 chr17:57184187 TRIM37 0.53 5.27 0.31 2.83e-7 Testicular germ cell tumor; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg21211866 chr9:35111727 KIAA1539 -0.47 -6.39 -0.37 7.59e-10 Height; CESC cis rs2576037 0.796 rs2576041 chr18:44580919 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.45 5.72 0.33 2.8e-8 Personality dimensions; CESC cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg00033643 chr7:134001901 SLC35B4 0.41 5.28 0.31 2.67e-7 Mean platelet volume; CESC cis rs9733 0.744 rs12568757 chr1:150729793 C/T cg13175981 chr1:150552382 MCL1 0.55 7.67 0.43 3.35e-13 Tonsillectomy; CESC cis rs17376456 0.741 rs12374432 chr5:93481348 C/A cg21475434 chr5:93447410 FAM172A 0.86 7.66 0.43 3.53e-13 Diabetic retinopathy; CESC cis rs2072732 0.756 rs7514166 chr1:2949607 G/C cg03976712 chr1:2946727 NA 0.34 5.63 0.33 4.53e-8 Plateletcrit; CESC cis rs7191439 0.522 rs745326 chr16:88755245 C/G cg27087555 chr16:88793112 FAM38A -0.83 -5.89 -0.34 1.19e-8 Plateletcrit; CESC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg10691866 chr7:65817282 TPST1 0.34 5.54 0.32 7.19e-8 Aortic root size; CESC cis rs2806561 0.894 rs629107 chr1:23537971 C/T cg12483005 chr1:23474871 LUZP1 0.32 5.12 0.3 5.77e-7 Height; CESC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg04025307 chr7:1156635 C7orf50 0.4 5.48 0.32 9.88e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg07507251 chr3:52567010 NT5DC2 -0.31 -5.29 -0.31 2.54e-7 Bipolar disorder; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08306513 chr11:120040083 NA 0.48 6.92 0.39 3.3e-11 Systemic lupus erythematosus; CESC cis rs9814567 0.963 rs36006513 chr3:134291913 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.1 0.35 3.71e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs3126085 0.935 rs12063165 chr1:152176357 C/T cg03465714 chr1:152285911 FLG -0.45 -5.45 -0.32 1.17e-7 Atopic dermatitis; CESC cis rs9916302 0.706 rs11078894 chr17:37396805 C/G cg07936489 chr17:37558343 FBXL20 -0.92 -10.72 -0.55 1.6e-22 Glomerular filtration rate (creatinine); CESC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -5.9 -0.34 1.11e-8 Tonsillectomy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24483304 chr1:43855122 MED8;C1orf84 0.49 6.29 0.36 1.32e-9 Gut microbiota (bacterial taxa); CESC cis rs6542838 0.641 rs13005124 chr2:99527680 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -5.1 -0.3 6.46e-7 Fear of minor pain; CESC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg24531977 chr5:56204891 C5orf35 0.62 8.47 0.46 1.69e-15 Initial pursuit acceleration; CESC cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg11742103 chr11:62369870 EML3;MTA2 0.63 9.6 0.51 6.49e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg17372223 chr3:52568218 NT5DC2 0.45 6.59 0.38 2.39e-10 Bipolar disorder; CESC cis rs9611519 0.929 rs73174657 chr22:41434158 G/A cg03806693 chr22:41940476 POLR3H -0.57 -5.92 -0.34 1.01e-8 Neuroticism; CESC trans rs1728785 1.000 rs1094282 chr16:68577260 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs7998202 0.614 rs420431 chr13:113346317 C/G cg02820901 chr13:113351484 ATP11A -0.63 -5.74 -0.33 2.59e-8 Glycated hemoglobin levels; CESC cis rs412050 0.948 rs34239349 chr22:22325624 G/A cg17089214 chr22:22089827 YPEL1 0.7 5.99 0.35 6.84e-9 Attention deficit hyperactivity disorder; CESC cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg03467027 chr4:99064603 C4orf37 0.43 5.42 0.32 1.34e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1030268 0.577 rs13244007 chr7:133260825 A/G cg10665199 chr7:133106180 EXOC4 0.5 5.32 0.31 2.25e-7 Intelligence (multi-trait analysis); CESC cis rs9815354 1.000 rs9867627 chr3:41795841 G/T cg03022575 chr3:42003672 ULK4 -0.54 -5.58 -0.32 6.05e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs1401999 1.000 rs869417 chr3:183689138 T/C cg01324343 chr3:183735012 ABCC5 0.62 13.05 0.63 2.19e-30 Anterior chamber depth; CESC cis rs7560272 0.501 rs13003035 chr2:73957227 T/A cg20560298 chr2:73613845 ALMS1 0.44 6.03 0.35 5.61e-9 Schizophrenia; CESC cis rs8060686 0.516 rs1971546 chr16:68280893 T/C cg26727032 chr16:67993705 SLC12A4 -0.57 -7.72 -0.43 2.32e-13 HDL cholesterol;Metabolic syndrome; CESC cis rs6061231 1.000 rs67941642 chr20:60958108 C/T cg06197360 chr20:60970103 CABLES2 -0.42 -5.42 -0.32 1.33e-7 Colorectal cancer; CESC cis rs7264396 0.676 rs58372200 chr20:34555445 C/A cg17201900 chr20:34330562 RBM39 0.51 5.31 0.31 2.37e-7 Total cholesterol levels; CESC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg20243544 chr17:37824526 PNMT 0.48 5.96 0.34 8.16e-9 Glomerular filtration rate (creatinine); CESC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg04315214 chr1:2043799 PRKCZ 0.54 9.35 0.5 3.89e-18 Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg11015017 chr19:18390607 JUND -0.48 -6.31 -0.36 1.17e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs12477438 0.501 rs7349217 chr2:99815146 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.91 15.67 0.69 1.24e-39 Chronic sinus infection; CESC cis rs1062177 0.826 rs2915822 chr5:151130901 G/T cg00977110 chr5:151150581 G3BP1 -0.58 -6.24 -0.36 1.72e-9 Preschool internalizing problems; CESC cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg19748678 chr4:122722346 EXOSC9 0.73 9.5 0.5 1.29e-18 Type 2 diabetes; CESC cis rs17094448 0.557 rs117276277 chr14:74497463 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.8 5.37 0.31 1.71e-7 Blood protein levels; CESC cis rs9902453 1.000 rs12600993 chr17:28291222 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.49 0.46 1.53e-15 Coffee consumption (cups per day); CESC cis rs1018836 0.632 rs6995399 chr8:91481629 T/C cg16814680 chr8:91681699 NA -0.59 -8.07 -0.44 2.51e-14 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9457247 0.935 rs1187530 chr6:167376812 C/T cg23791538 chr6:167370224 RNASET2 0.6 8.57 0.47 8.75e-16 Crohn's disease; CESC cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg19723775 chr5:179050963 HNRNPH1 0.41 5.46 0.32 1.08e-7 Lung cancer; CESC cis rs5769765 0.874 rs4624 chr22:50281917 A/G cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs7017914 0.902 rs10504481 chr8:71699517 T/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.3 -0.31 2.38e-7 Bone mineral density; CESC cis rs2180341 1.000 rs9385419 chr6:127597591 A/G cg24812749 chr6:127587940 RNF146 1.06 15.23 0.68 4.52e-38 Breast cancer; CESC cis rs7216064 0.953 rs75231441 chr17:65885485 A/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.82 -0.48 1.55e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7580658 0.817 rs6761447 chr2:128074573 A/T cg10021288 chr2:128175891 PROC -0.41 -6.5 -0.37 4.02e-10 Protein C levels; CESC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg06636001 chr8:8085503 FLJ10661 -0.42 -5.43 -0.32 1.25e-7 Mood instability; CESC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg00409905 chr10:38381863 ZNF37A -0.45 -6.01 -0.35 6.11e-9 Extrinsic epigenetic age acceleration; CESC cis rs6500602 0.767 rs8060219 chr16:4480158 T/A cg08645402 chr16:4508243 NA 0.41 6.25 0.36 1.59e-9 Schizophrenia; CESC cis rs11581903 0.568 rs11205977 chr1:53068093 G/T cg19751897 chr1:52520827 TXNDC12;BTF3L4 0.73 5.47 0.32 1.06e-7 Joint mobility (Beighton score); CESC cis rs9399135 0.967 rs6910530 chr6:135332770 C/T cg22676075 chr6:135203613 NA 0.51 7.16 0.4 7.86e-12 Red blood cell count; CESC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg24250549 chr1:154909240 PMVK -0.41 -5.28 -0.31 2.69e-7 Schizophrenia; CESC trans rs13398848 1.000 rs10168676 chr2:84201254 A/G cg23262351 chr6:79576851 IRAK1BP1 -0.69 -6.08 -0.35 4.1e-9 Conduct disorder (symptom count);Conduct disorder; CESC cis rs9815354 1.000 rs7624372 chr3:41881107 T/A cg03022575 chr3:42003672 ULK4 0.45 5.29 0.31 2.59e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg04944784 chr2:26401820 FAM59B -0.67 -7.75 -0.43 2e-13 Gut microbiome composition (summer); CESC cis rs35146811 0.844 rs13232115 chr7:99670932 T/C cg13334819 chr7:99746414 C7orf59 -0.43 -5.27 -0.31 2.79e-7 Coronary artery disease; CESC cis rs911555 0.755 rs8014800 chr14:103946302 T/C cg12935359 chr14:103987150 CKB 0.67 9.78 0.52 1.73e-19 Intelligence (multi-trait analysis); CESC cis rs11252926 0.501 rs2050971 chr10:525530 T/G cg18196295 chr10:418757 DIP2C -0.5 -6.72 -0.38 1.1e-10 Psychosis in Alzheimer's disease; CESC cis rs2204008 0.701 rs3898237 chr12:38219714 A/G cg26384229 chr12:38710491 ALG10B 0.74 10.65 0.55 2.74e-22 Bladder cancer; CESC cis rs4132509 0.779 rs1538773 chr1:243674682 T/G cg21452805 chr1:244014465 NA 0.41 5.03 0.3 9.21e-7 RR interval (heart rate); CESC cis rs208520 0.690 rs10455595 chr6:66738034 T/C cg07460842 chr6:66804631 NA 0.96 12.87 0.62 8.96e-30 Exhaled nitric oxide output; CESC cis rs6460942 0.544 rs34644264 chr7:12536090 C/A cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC trans rs208515 0.525 rs10944859 chr6:66665197 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 10.74 0.55 1.42e-22 Exhaled nitric oxide levels; CESC cis rs662064 0.962 rs2781232 chr1:10544388 T/C cg20482658 chr1:10539492 PEX14 -0.41 -8.23 -0.45 8.65e-15 Asthma; CESC cis rs2777491 0.915 rs8032838 chr15:41605632 G/A cg18705301 chr15:41695430 NDUFAF1 -0.6 -8.84 -0.48 1.39e-16 Ulcerative colitis; CESC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs80130819 0.688 rs7313023 chr12:48584179 T/C cg05342945 chr12:48394962 COL2A1 -0.52 -5.88 -0.34 1.26e-8 Prostate cancer; CESC cis rs1018836 0.923 rs6986689 chr8:91626709 A/C cg16814680 chr8:91681699 NA -0.72 -10.07 -0.53 2.16e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1577917 0.771 rs9353318 chr6:86231721 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.57 7.88 0.44 8.64e-14 Response to antipsychotic treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06212498 chr3:49045151 WDR6 0.64 7.14 0.4 8.77e-12 Gut microbiome composition (summer); CESC cis rs400736 0.655 rs55634431 chr1:8149549 G/A cg25007680 chr1:8021821 PARK7 -0.64 -8.79 -0.48 1.86e-16 Response to antidepressants and depression; CESC cis rs4523957 0.560 rs1994884 chr17:2084008 G/A cg16513277 chr17:2031491 SMG6 -0.71 -10.17 -0.53 1.04e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11583043 0.708 rs36023027 chr1:101575205 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.56 0.32 6.53e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs4979906 1.000 rs4325263 chr10:79444236 A/G cg00983440 chr10:79422392 NA -0.48 -5.1 -0.3 6.57e-7 Mortality in heart failure; CESC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg08888203 chr3:10149979 C3orf24 0.53 6.83 0.39 5.8200000000000003e-11 Alzheimer's disease; CESC cis rs875971 0.662 rs448725 chr7:65514628 A/G cg18876405 chr7:65276391 NA 0.56 7.47 0.42 1.15e-12 Aortic root size; CESC cis rs7208859 0.623 rs55961983 chr17:29119286 G/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7587476 0.736 rs62202002 chr2:215690600 T/C cg04004882 chr2:215674386 BARD1 0.53 5.91 0.34 1.05e-8 Neuroblastoma; CESC cis rs4924935 0.851 rs12936834 chr17:18807078 A/G cg26378065 chr17:18585709 ZNF286B 0.47 5.4 0.31 1.47e-7 Pancreatic cancer; CESC cis rs763121 0.849 rs12004 chr22:38877461 T/G cg06544989 chr22:39130855 UNC84B 0.46 7.51 0.42 9.02e-13 Menopause (age at onset); CESC cis rs1707322 1.000 rs6676982 chr1:46275401 A/T cg06784218 chr1:46089804 CCDC17 0.33 5.75 0.33 2.42e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2243480 1.000 rs1553174 chr7:65731194 T/C cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC cis rs34779708 0.733 rs12249814 chr10:35542757 T/C cg03585969 chr10:35415529 CREM 0.56 6.42 0.37 6.15e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18673246 chr17:7217969 GPS2 -0.6 -7.14 -0.4 9.03e-12 Gut microbiome composition (summer); CESC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.51 6.04 0.35 5.07e-9 Breast cancer; CESC cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6430585 0.583 rs3087343 chr2:136622543 T/G cg07169764 chr2:136633963 MCM6 1.29 19.97 0.78 9.47e-55 Corneal structure; CESC cis rs7843479 0.562 rs2127206 chr8:21786989 C/T cg17168535 chr8:21777572 XPO7 0.7 11.38 0.57 1.12e-24 Mean corpuscular volume; CESC cis rs9868809 0.772 rs9841602 chr3:48713570 A/G cg06212747 chr3:49208901 KLHDC8B -0.57 -5.06 -0.3 7.97e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg23803603 chr1:2058230 PRKCZ -0.34 -5.74 -0.33 2.54e-8 Height; CESC cis rs7666738 0.546 rs34621463 chr4:98793357 G/C cg05340658 chr4:99064831 C4orf37 0.58 7.25 0.41 4.5e-12 Colonoscopy-negative controls vs population controls; CESC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg02018176 chr4:1364513 KIAA1530 0.61 8.08 0.44 2.33e-14 Longevity; CESC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg23281280 chr6:28129359 ZNF389 0.5 6.27 0.36 1.46e-9 Parkinson's disease; CESC cis rs8092503 1.000 rs8093506 chr18:52474170 A/G cg12377874 chr18:52495404 RAB27B 0.37 5.83 0.34 1.64e-8 Childhood body mass index; CESC cis rs7247513 0.964 rs8100964 chr19:12720631 C/T cg01871581 chr19:12707946 ZNF490 -0.86 -13.76 -0.65 7.13e-33 Bipolar disorder; CESC cis rs3785574 0.962 rs2727280 chr17:61918082 A/G cg06873352 chr17:61820015 STRADA 0.47 6.63 0.38 1.92e-10 Height; CESC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg07157834 chr1:205819609 PM20D1 0.71 11.02 0.56 1.73e-23 Menarche (age at onset); CESC cis rs6460942 1.000 rs117657017 chr7:12318891 T/C cg02935154 chr7:12443704 VWDE -0.59 -5.84 -0.34 1.5e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06916931 chr13:49106753 RCBTB2 0.55 6.54 0.37 3.22e-10 Gut microbiome composition (summer); CESC cis rs2404602 0.692 rs55676827 chr15:76961716 C/T cg26408565 chr15:76604113 ETFA -0.39 -5.58 -0.32 5.8e-8 Blood metabolite levels; CESC cis rs7918232 0.941 rs1085782 chr10:27440517 G/A cg14240646 chr10:27532245 ACBD5 0.68 6.49 0.37 4.18e-10 Breast cancer; CESC cis rs1003719 0.654 rs764175 chr21:38517058 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.14 -0.45 1.51e-14 Eye color traits; CESC cis rs10851478 0.872 rs11854671 chr15:49765426 C/T cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.16 0.3 4.79e-7 Oral cavity cancer; CESC cis rs9640161 0.750 rs3735169 chr7:150034378 A/G cg17279839 chr7:150038598 RARRES2 0.45 5.44 0.32 1.2e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs13082711 0.871 rs7624790 chr3:27468601 C/A cg02860705 chr3:27208620 NA 0.53 6.8 0.39 7.04e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs10504229 0.679 rs60869047 chr8:58053221 G/A cg24829409 chr8:58192753 C8orf71 -0.5 -6.27 -0.36 1.43e-9 Developmental language disorder (linguistic errors); CESC cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.19 0.3 4.18e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg23758822 chr17:41437982 NA 1.03 15.53 0.69 4.02e-39 Menopause (age at onset); CESC cis rs2790457 0.874 rs1265840 chr10:28919641 C/T cg04045419 chr10:28823091 WAC -0.42 -5.04 -0.3 8.49e-7 Multiple myeloma; CESC cis rs1348850 0.914 rs11893448 chr2:178280013 T/C cg22681709 chr2:178499509 PDE11A -0.42 -6.23 -0.36 1.79e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1065656 0.571 rs12149777 chr16:1834724 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.4 -5.54 -0.32 7.41e-8 Insulin-like growth factors; CESC cis rs9611565 0.546 rs739129 chr22:42118249 G/A cg03806693 chr22:41940476 POLR3H 1.15 13.67 0.64 1.42e-32 Vitiligo; CESC cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.54 0.46 1.08e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9309473 1.000 rs13431267 chr2:73782200 A/G cg20560298 chr2:73613845 ALMS1 -0.54 -7.08 -0.4 1.31e-11 Metabolite levels; CESC cis rs3096299 0.935 rs3102387 chr16:89432276 A/C cg08822215 chr16:89438651 ANKRD11 -0.41 -6.19 -0.36 2.22e-9 Multiple myeloma (IgH translocation); CESC trans rs7079041 1 rs7079041 chr10:32993268 G/A cg01456440 chr13:21714647 SAP18 -0.5 -6.41 -0.37 6.77e-10 Suicide in bipolar disorder; CESC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg09913183 chr17:42254507 C17orf65;ASB16 0.65 8.64 0.47 5.22e-16 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26645063 chr2:65454766 ACTR2 0.56 6.12 0.35 3.42e-9 Gut microbiome composition (summer); CESC trans rs61931739 0.500 rs11053140 chr12:34316122 T/C cg26384229 chr12:38710491 ALG10B 0.65 9.19 0.49 1.16e-17 Morning vs. evening chronotype; CESC cis rs79839061 0.656 rs3775126 chr4:886345 C/T cg07828340 chr4:882639 GAK 1.07 8.55 0.47 9.76e-16 Intelligence (multi-trait analysis); CESC cis rs7165102 1.000 rs429657 chr15:65813764 G/A cg11441148 chr15:65824328 PTPLAD1 -0.32 -5.38 -0.31 1.61e-7 Mean corpuscular hemoglobin; CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg16103275 chr6:290800 DUSP22 0.44 6.02 0.35 5.78e-9 Menopause (age at onset); CESC cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg15506890 chr2:3487001 NA -0.42 -5.24 -0.31 3.22e-7 Neurofibrillary tangles; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15891076 chr10:65930618 NA -0.55 -6.15 -0.35 2.89e-9 Gut microbiome composition (summer); CESC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.42 -5.39 -0.31 1.59e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6570726 0.875 rs368744 chr6:145812622 A/G cg23711669 chr6:146136114 FBXO30 0.78 11.22 0.57 3.67e-24 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09133562 chr1:20126395 TMCO4 0.6 6.62 0.38 2e-10 Gut microbiome composition (summer); CESC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.08 0.4 1.32e-11 Height; CESC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.06 -0.35 4.65e-9 Parkinson's disease; CESC cis rs4919694 1.000 rs58317752 chr10:104799267 T/A cg04362960 chr10:104952993 NT5C2 0.79 6.94 0.39 2.92e-11 Arsenic metabolism; CESC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.47 6.24 0.36 1.71e-9 Lymphocyte counts; CESC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC cis rs5750830 0.645 rs756640 chr22:39779300 G/A cg05872129 chr22:39784769 NA -0.74 -10.84 -0.55 6.72e-23 Intelligence (multi-trait analysis); CESC cis rs644799 1.000 rs474442 chr11:95583995 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.36 0.5 3.46e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9399135 0.660 rs4440481 chr6:135276696 A/G cg24558204 chr6:135376177 HBS1L 0.53 7.34 0.41 2.55e-12 Red blood cell count; CESC cis rs67478160 0.619 rs1040813 chr14:104306696 T/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.18 -0.4 7.24e-12 Schizophrenia; CESC cis rs12618769 0.597 rs3769738 chr2:99078367 T/C cg10123293 chr2:99228465 UNC50 0.41 5.42 0.32 1.36e-7 Bipolar disorder; CESC cis rs11148252 0.553 rs7999849 chr13:53249414 A/G cg00495681 chr13:53174319 NA 0.6 8.21 0.45 9.62e-15 Lewy body disease; CESC cis rs2486288 0.656 rs11637364 chr15:45579238 C/T cg21132104 chr15:45694354 SPATA5L1 -0.6 -7.19 -0.4 6.71e-12 Glomerular filtration rate; CESC cis rs1570884 0.516 rs9316463 chr13:50176844 G/A cg03651054 chr13:50194643 NA 0.31 5.1 0.3 6.4e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg16928487 chr17:17741425 SREBF1 0.41 6.01 0.35 5.97e-9 Body mass index; CESC cis rs3812762 0.833 rs10500707 chr11:8817580 C/T cg03980550 chr11:8754370 ST5 0.39 5.22 0.31 3.62e-7 Hypospadias; CESC cis rs7512552 0.839 rs1694369 chr1:150351101 A/G cg15654264 chr1:150340011 RPRD2 0.39 5.13 0.3 5.73e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg10691866 chr7:65817282 TPST1 0.33 5.52 0.32 8.11e-8 Aortic root size; CESC cis rs11864453 0.713 rs6680 chr16:72146570 T/C cg01557791 chr16:72042693 DHODH -0.48 -6.35 -0.36 9.29e-10 Fibrinogen levels; CESC cis rs1499614 1.000 rs2659913 chr7:66157336 T/A cg18252515 chr7:66147081 NA -1.42 -14.62 -0.67 6.69e-36 Gout; CESC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2228479 0.850 rs11649510 chr16:89851004 A/G cg06558623 chr16:89946397 TCF25 1.18 9.42 0.5 2.3e-18 Skin colour saturation; CESC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg19163074 chr7:65112434 INTS4L2 0.4 5.16 0.3 4.86e-7 Aortic root size; CESC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg04267008 chr7:1944627 MAD1L1 -0.5 -5.81 -0.34 1.75e-8 Bipolar disorder and schizophrenia; CESC trans rs1120787 0.793 rs478765 chr18:55013866 C/T cg03862225 chr10:126850454 CTBP2 -0.54 -6.11 -0.35 3.53e-9 HIV-1 control; CESC cis rs3820068 0.603 rs41270279 chr1:15988878 A/G cg13390004 chr1:15929781 NA 0.34 5.49 0.32 9.33e-8 Systolic blood pressure; CESC cis rs9916302 0.904 rs755500 chr17:37409865 C/T cg20243544 chr17:37824526 PNMT 0.48 5.81 0.34 1.81e-8 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.41 0.37 6.57e-10 Prudent dietary pattern; CESC cis rs9611565 0.729 rs12165508 chr22:41819960 T/C cg03806693 chr22:41940476 POLR3H 0.77 9.87 0.52 9.21e-20 Vitiligo; CESC cis rs9303401 0.659 rs34818467 chr17:56643109 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.8 -10.1 -0.53 1.73e-20 Cognitive test performance; CESC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg10691866 chr7:65817282 TPST1 -0.36 -5.92 -0.34 9.82e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11028091 chr15:72522207 PKM2 -0.6 -7.03 -0.4 1.78e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07853743 chr16:2802190 SRRM2;LOC100128788 0.64 7.03 0.4 1.71e-11 Gut microbiome composition (summer); CESC cis rs6736093 0.862 rs11684321 chr2:112775750 C/T cg12686935 chr2:112915763 FBLN7 -0.41 -5.21 -0.3 3.87e-7 Coronary artery disease; CESC cis rs57502260 0.704 rs60538784 chr11:68386735 G/A cg20283391 chr11:68216788 NA -0.6 -5.04 -0.3 8.8e-7 Total body bone mineral density (age 45-60); CESC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg25072359 chr17:41440525 NA 0.48 7.22 0.41 5.37e-12 Menopause (age at onset); CESC cis rs6088580 0.634 rs6142153 chr20:32968747 C/G cg24642439 chr20:33292090 TP53INP2 -0.53 -7.01 -0.4 2.01e-11 Glomerular filtration rate (creatinine); CESC cis rs6964587 0.967 rs6465340 chr7:91588664 G/A cg17063962 chr7:91808500 NA 0.57 7.74 0.43 2.17e-13 Breast cancer; CESC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg13206674 chr6:150067644 NUP43 0.43 6.18 0.35 2.39e-9 Lung cancer; CESC trans rs11722228 0.508 rs2241472 chr4:10085902 C/G cg26043149 chr18:55253948 FECH 0.94 11.05 0.56 1.31e-23 Gout;Urate levels;Serum uric acid levels; CESC cis rs8058578 1.000 rs6565201 chr16:30747191 C/T cg02466173 chr16:30829666 NA -0.41 -6.69 -0.38 1.3100000000000001e-10 Multiple myeloma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02751639 chr2:112641883 ANAPC1 0.54 6.03 0.35 5.61e-9 Gut microbiome composition (summer); CESC cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg20887711 chr4:1340912 KIAA1530 0.42 5.65 0.33 4.13e-8 Longevity; CESC cis rs9457247 1.000 rs393558 chr6:167397750 A/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.41 -0.46 2.56e-15 Crohn's disease; CESC trans rs1814175 0.712 rs9665784 chr11:50030617 C/T cg15704280 chr7:45808275 SEPT13 -1.05 -21.42 -0.8 9.36e-60 Height; CESC cis rs67257959 0.708 rs10405158 chr19:17195997 A/G cg16202187 chr19:17186497 HAUS8;MYO9B 0.45 5.41 0.32 1.42e-7 Selective IgA deficiency; CESC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg03388025 chr16:89894329 SPIRE2 0.39 7.4 0.41 1.76e-12 Vitiligo; CESC cis rs796364 0.760 rs56285751 chr2:200919836 C/T cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC cis rs7216064 0.911 rs6504551 chr17:65903326 T/G cg07042672 chr17:66097459 LOC651250 -0.55 -7.4 -0.41 1.8e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg24531977 chr5:56204891 C5orf35 -0.88 -11.37 -0.57 1.16e-24 Initial pursuit acceleration; CESC cis rs11098499 0.820 rs28394116 chr4:120524283 T/G cg24375607 chr4:120327624 NA 0.43 5.28 0.31 2.66e-7 Corneal astigmatism; CESC cis rs7580658 0.550 rs62160290 chr2:128200695 C/T cg10021288 chr2:128175891 PROC -0.4 -5.92 -0.34 1e-8 Protein C levels; CESC cis rs2274273 0.662 rs2094436 chr14:55661495 C/G cg04306507 chr14:55594613 LGALS3 0.31 5.27 0.31 2.78e-7 Protein biomarker; CESC trans rs7178375 1.000 rs28693590 chr15:31195021 A/G cg04373760 chr16:53404718 NA 0.55 7.21 0.4 5.95e-12 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25233569 chr10:62703741 RHOBTB1 0.66 7.27 0.41 4.08e-12 Gut microbiome composition (summer); CESC cis rs3106136 0.967 rs13135934 chr4:95207688 G/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.75 -0.38 9.27e-11 Capecitabine sensitivity; CESC cis rs6736093 0.700 rs4848958 chr2:112785775 T/C cg07905836 chr2:113190072 RGPD8;RGPD5 -0.48 -5.54 -0.32 7.35e-8 Coronary artery disease; CESC cis rs9858542 0.953 rs35261698 chr3:49537839 C/G cg03060546 chr3:49711283 APEH -0.55 -6.28 -0.36 1.34e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4948102 0.551 rs4275190 chr7:56104388 C/T cg09872392 chr7:56161020 PHKG1 -0.48 -7.82 -0.43 1.26e-13 Plasma homocysteine levels (post-methionine load test); CESC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg07870213 chr5:140052090 DND1 -0.61 -6.87 -0.39 4.47e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2635047 0.638 rs2635054 chr18:44653028 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.39 -5.39 -0.31 1.55e-7 Educational attainment; CESC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg27266060 chr8:22091797 NA 0.42 8.42 0.46 2.39e-15 Hypertriglyceridemia; CESC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.62 6.9 0.39 3.91e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8062405 0.691 rs11646653 chr16:28922149 C/T cg05966235 chr16:28915196 ATP2A1 -0.34 -5.06 -0.3 7.84e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6714710 0.603 rs1875699 chr2:98580724 G/T cg26665480 chr2:98280029 ACTR1B 0.56 7.9 0.44 7.59e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs2486288 0.656 rs12908818 chr15:45571668 A/G cg09092052 chr15:45571596 NA 0.44 5.23 0.31 3.44e-7 Glomerular filtration rate; CESC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg19774624 chr17:42201019 HDAC5 -0.68 -9.97 -0.52 4.48e-20 Total body bone mineral density; CESC cis rs897984 0.609 rs57576577 chr16:31036367 G/A cg02466173 chr16:30829666 NA -0.4 -6.95 -0.39 2.84e-11 Dementia with Lewy bodies; CESC cis rs7542091 0.637 rs9429826 chr1:210052146 G/A cg22029157 chr1:209979665 IRF6 0.49 7.73 0.43 2.23e-13 Monobrow; CESC cis rs924607 1.000 rs11746907 chr5:598224 G/A cg07001201 chr5:642380 CEP72 0.39 5.1 0.3 6.55e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9859260 0.710 rs34906439 chr3:195779706 A/G cg12923728 chr3:195709715 SDHAP1 0.54 6.95 0.39 2.78e-11 Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06569419 chr2:182827064 NA 0.37 6.56 0.37 2.75e-10 Gambling; CESC cis rs28647808 1.000 rs6597630 chr9:136279935 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs7312774 0.618 rs10861680 chr12:107323730 T/C cg16260113 chr12:107380972 MTERFD3 0.78 7.11 0.4 1.05e-11 Severe influenza A (H1N1) infection; CESC cis rs2109514 1.000 rs2270188 chr7:116140524 G/T cg12739419 chr7:116140593 CAV2 -0.37 -6.71 -0.38 1.17e-10 Prevalent atrial fibrillation; CESC cis rs2180341 0.538 rs11556354 chr6:127664661 G/A cg24812749 chr6:127587940 RNF146 0.51 6.82 0.39 6.2e-11 Breast cancer; CESC cis rs75804782 0.641 rs72985397 chr2:239341354 A/G cg18131467 chr2:239335373 ASB1 -0.67 -5.7 -0.33 3.14e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs7264396 0.563 rs6060567 chr20:34288250 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.9 -10.87 -0.56 5.11e-23 Total cholesterol levels; CESC cis rs12144309 0.554 rs2476602 chr1:114396955 C/T cg13572289 chr1:114447746 DCLRE1B;AP4B1 0.44 5.2 0.3 4.07e-7 Coronary artery disease; CESC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.12 -0.4 1.02e-11 Personality dimensions; CESC cis rs765787 0.556 rs12915965 chr15:45512647 T/C cg24006582 chr15:45444508 DUOX1 0.52 6.32 0.36 1.13e-9 Uric acid levels; CESC cis rs1568889 0.712 rs4567438 chr11:28380051 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.69 8.53 0.46 1.12e-15 Bipolar disorder; CESC cis rs2243480 1.000 rs4718270 chr7:65202407 A/G cg12463550 chr7:65579703 CRCP 0.68 5.29 0.31 2.55e-7 Diabetic kidney disease; CESC cis rs925228 0.504 rs6755030 chr2:24318343 C/T cg01493198 chr2:24299560 SF3B14 0.66 5.79 0.34 1.97e-8 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs77861329 1.000 rs9857878 chr3:52109668 A/G cg08692210 chr3:52188851 WDR51A -0.83 -7.03 -0.4 1.73e-11 Macrophage inflammatory protein 1b levels; CESC cis rs75920871 0.589 rs2075547 chr11:117068534 G/T cg01368799 chr11:117014884 PAFAH1B2 -0.71 -5.35 -0.31 1.87e-7 Subjective well-being; CESC cis rs6474412 1.000 rs4950 chr8:42552633 C/T cg25026480 chr8:42547641 NA 0.32 5.29 0.31 2.54e-7 Smoking behavior; CESC cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg04455712 chr21:45112962 RRP1B 0.51 7.91 0.44 7.22e-14 Mean corpuscular volume; CESC trans rs17433710 0.543 rs10753585 chr1:162669006 C/T cg13392022 chr1:154600693 ADAR -0.45 -6.04 -0.35 5.09e-9 Dupuytren's disease; CESC cis rs9470366 0.816 rs4331968 chr6:36623243 A/T cg08179530 chr6:36648295 CDKN1A 0.56 6.66 0.38 1.61e-10 QRS duration; CESC trans rs7607369 0.782 rs514799 chr2:219411203 A/G cg15547669 chr20:2781122 CPXM1 0.35 6.0 0.35 6.31e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs7666738 0.606 rs4577589 chr4:99087858 A/G cg24818145 chr4:99064322 C4orf37 0.4 5.14 0.3 5.32e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11711311 1.000 rs9830978 chr3:113455940 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.27 0.53 4.81e-21 IgG glycosylation; CESC cis rs9612 1.000 rs346523 chr19:44260681 A/C cg08581076 chr19:44259116 C19orf61 0.52 6.19 0.36 2.33e-9 Exhaled nitric oxide output; CESC cis rs2737618 0.722 rs2258675 chr1:200091548 G/C cg21825944 chr1:200113062 NR5A2 -0.38 -5.43 -0.32 1.28e-7 Uric acid levels; CESC cis rs7107174 1.000 rs4945270 chr11:78068216 A/G cg02023728 chr11:77925099 USP35 0.48 6.3 0.36 1.23e-9 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17634588 chr8:141646421 EIF2C2 0.61 6.89 0.39 3.99e-11 Gut microbiome composition (summer); CESC trans rs5756813 0.727 rs4821703 chr22:38136676 C/T cg19894588 chr14:64061835 NA -0.67 -7.81 -0.43 1.32e-13 Optic cup area;Vertical cup-disc ratio; CESC trans rs6987853 0.830 rs4737048 chr8:42359035 G/T cg27650678 chr11:66636318 PC -0.46 -6.11 -0.35 3.45e-9 Mean corpuscular hemoglobin concentration; CESC cis rs7666738 0.830 rs28867087 chr4:98880349 T/A cg03467027 chr4:99064603 C4orf37 0.42 5.25 0.31 3.05e-7 Colonoscopy-negative controls vs population controls; CESC trans rs875971 1.000 rs2420591 chr7:65912381 T/C cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.6e-9 Aortic root size; CESC cis rs1341267 0.529 rs6492721 chr13:95258944 A/G cg18412871 chr13:95254051 GPR180 -0.56 -7.54 -0.42 7.58e-13 Triglyceride levels; CESC cis rs7666738 0.830 rs2114426 chr4:98933130 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs56043030 chr5:220917 A/G cg10591111 chr5:226296 SDHA -0.51 -6.35 -0.36 9.22e-10 Breast cancer; CESC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg19770292 chr5:1868693 NA 0.31 5.28 0.31 2.73e-7 Cardiovascular disease risk factors; CESC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg25517755 chr10:38738941 LOC399744 -0.49 -6.41 -0.37 6.52e-10 Extrinsic epigenetic age acceleration; CESC cis rs4654899 0.965 rs7525620 chr1:21458392 G/A cg05370193 chr1:21551575 ECE1 0.41 6.2 0.36 2.2e-9 Superior frontal gyrus grey matter volume; CESC cis rs67478160 0.643 rs8005594 chr14:104279889 T/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.04 -0.4 1.62e-11 Schizophrenia; CESC cis rs12190007 0.547 rs3006182 chr6:169808323 C/T cg15038512 chr6:170123185 PHF10 -0.48 -6.81 -0.39 6.6e-11 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00291661 chr16:30581198 ZNF688 0.49 6.53 0.37 3.3e-10 Fibrinogen levels; CESC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg06074448 chr4:187884817 NA -0.46 -7.14 -0.4 8.73e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs796364 0.806 rs79156935 chr2:200913822 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs10392 0.602 rs4810240 chr20:37532033 G/A cg27552599 chr20:37590471 DHX35 0.38 5.13 0.3 5.5e-7 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs4835473 0.800 rs2175451 chr4:144914117 T/C cg25736465 chr4:144833511 NA 0.43 6.44 0.37 5.61e-10 Immature fraction of reticulocytes; CESC cis rs7116495 0.609 rs12275171 chr11:71835373 C/T cg26138937 chr11:71823887 C11orf51 1.23 7.77 0.43 1.75e-13 Severe influenza A (H1N1) infection; CESC cis rs6456156 0.846 rs204293 chr6:167514481 T/C cg07741184 chr6:167504864 NA 0.35 6.18 0.36 2.37e-9 Primary biliary cholangitis; CESC cis rs9640161 0.830 rs3735165 chr7:150068371 T/C cg27494647 chr7:150038898 RARRES2 0.36 5.4 0.31 1.48e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs244293 0.730 rs3213757 chr17:53041857 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.45 -6.14 -0.35 3.02e-9 Menarche (age at onset); CESC cis rs16854884 0.837 rs989665 chr3:143792854 C/T cg06585982 chr3:143692056 C3orf58 0.44 5.49 0.32 9.61e-8 Economic and political preferences (feminism/equality); CESC cis rs6540556 0.723 rs6752 chr1:209908100 G/A cg05527609 chr1:210001259 C1orf107 -0.63 -7.21 -0.41 5.81e-12 Red blood cell count; CESC cis rs113835537 0.529 rs61561111 chr11:66275923 T/C cg24851651 chr11:66362959 CCS 0.44 5.49 0.32 9.2e-8 Airway imaging phenotypes; CESC cis rs1538970 1.000 rs1417578 chr1:45850590 A/G cg06784218 chr1:46089804 CCDC17 0.3 5.19 0.3 4.14e-7 Platelet count; CESC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg01448562 chr3:133502909 NA -0.44 -6.1 -0.35 3.8e-9 Iron status biomarkers; CESC cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg05347473 chr6:146136440 FBXO30 0.59 7.56 0.42 6.43e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs117623576 0.941 rs211424 chr10:32398895 A/G cg03047570 chr10:32398778 NA 0.62 6.65 0.38 1.68e-10 Anti-saccade response; CESC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC cis rs7216064 1.000 rs62084248 chr17:65874541 C/T cg07042672 chr17:66097459 LOC651250 -0.52 -5.4 -0.31 1.5e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs72781680 0.611 rs72781695 chr2:24266744 T/C cg06627628 chr2:24431161 ITSN2 -0.65 -6.21 -0.36 2.08e-9 Lymphocyte counts; CESC trans rs60843830 1.000 rs58461606 chr2:267367 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 8.47 0.46 1.72e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg03806693 chr22:41940476 POLR3H 1.13 15.47 0.69 6.47e-39 Vitiligo; CESC cis rs2506889 0.553 rs7548453 chr1:10589836 A/G cg07384165 chr1:10488281 NA -0.55 -7.92 -0.44 6.54e-14 Breast cancer; CESC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg06873352 chr17:61820015 STRADA 0.45 6.62 0.38 1.96e-10 Height; CESC cis rs11608355 0.521 rs1119271 chr12:109819727 A/T cg19025524 chr12:109796872 NA -0.55 -7.9 -0.44 7.54e-14 Neuroticism; CESC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg05872129 chr22:39784769 NA -0.81 -10.78 -0.55 1.07e-22 Intelligence (multi-trait analysis); CESC cis rs66887589 0.592 rs11731571 chr4:120221185 G/A cg09307838 chr4:120376055 NA 0.65 8.97 0.48 5.51e-17 Diastolic blood pressure; CESC cis rs3767633 0.925 rs2134696 chr1:161781200 A/T cg09175582 chr1:161736000 ATF6 -0.78 -7.23 -0.41 5.24e-12 IgG glycosylation; CESC cis rs9633740 1.000 rs9633740 chr10:82265271 A/G cg00277334 chr10:82204260 NA -0.57 -5.71 -0.33 3e-8 Post bronchodilator FEV1; CESC cis rs854765 0.547 rs4072739 chr17:17884660 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.69 0.38 1.3100000000000001e-10 Total body bone mineral density; CESC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg08888203 chr3:10149979 C3orf24 0.49 6.14 0.35 3.07e-9 Alzheimer's disease; CESC trans rs7628583 0.696 rs12488626 chr3:64071952 C/A cg08189171 chr12:6420023 PLEKHG6 -0.57 -6.2 -0.36 2.15e-9 Parental extreme longevity (95 years and older); CESC cis rs13064411 0.735 rs9875025 chr3:113147552 T/C cg18753928 chr3:113234510 CCDC52 -0.46 -5.45 -0.32 1.13e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs3825932 0.744 rs11072818 chr15:79236933 A/G cg25744700 chr15:79237217 CTSH 0.49 6.47 0.37 4.79e-10 Type 1 diabetes; CESC cis rs79349575 0.811 rs1057897 chr17:47005509 T/G cg16584676 chr17:46985605 UBE2Z 0.52 6.38 0.37 7.67e-10 Type 2 diabetes; CESC cis rs7103648 0.630 rs7120548 chr11:47662932 A/G cg20307385 chr11:47447363 PSMC3 0.81 12.49 0.61 1.92e-28 Diastolic blood pressure;Systolic blood pressure; CESC cis rs965469 1.000 rs2281500 chr20:3262824 C/T cg25506879 chr20:3388711 C20orf194 -0.55 -6.05 -0.35 4.82e-9 IFN-related cytopenia; CESC cis rs2243480 1.000 rs60683927 chr7:65394768 T/C cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs6547741 0.844 rs9678851 chr2:27887034 C/A cg27432699 chr2:27873401 GPN1 -0.59 -8.6 -0.47 6.89e-16 Oral cavity cancer; CESC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg18099408 chr3:52552593 STAB1 -0.3 -5.05 -0.3 8.14e-7 Bipolar disorder; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg03115081 chr17:74722049 C17orf95;JMJD6 -0.49 -6.86 -0.39 4.96e-11 Height; CESC cis rs17401966 0.838 rs12125535 chr1:10350849 T/A cg15208524 chr1:10270712 KIF1B 0.41 5.32 0.31 2.16e-7 Hepatocellular carcinoma; CESC cis rs2637266 0.935 rs2637265 chr10:78326104 A/G cg18941641 chr10:78392320 NA 0.38 6.83 0.39 5.66e-11 Pulmonary function; CESC cis rs4268898 0.552 rs12621083 chr2:24367540 C/T cg20701182 chr2:24300061 SF3B14 -0.39 -5.47 -0.32 1.03e-7 Asthma; CESC cis rs7301826 0.651 rs2277336 chr12:131286119 A/G cg11011512 chr12:131303247 STX2 -0.47 -5.59 -0.32 5.74e-8 Plasma plasminogen activator levels; CESC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.1 -0.3 6.36e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs10489202 0.583 rs201539 chr1:167995407 A/G cg24449463 chr1:168025552 DCAF6 -0.4 -5.14 -0.3 5.43e-7 Schizophrenia; CESC cis rs11785693 0.866 rs11782170 chr8:4976942 A/G cg26367366 chr8:4980734 NA -0.85 -7.58 -0.42 5.67e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg17911788 chr17:44343683 NA -0.43 -6.7 -0.38 1.22e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg16325326 chr1:53192061 ZYG11B 0.72 11.92 0.59 1.6e-26 Monocyte count; CESC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg22535103 chr8:58192502 C8orf71 -0.93 -10.39 -0.54 1.89e-21 Developmental language disorder (linguistic errors); CESC cis rs7809950 1.000 rs10274041 chr7:107261556 C/T cg23024343 chr7:107201750 COG5 0.43 5.91 0.34 1.02e-8 Coronary artery disease; CESC cis rs6691722 0.503 rs3765425 chr1:24699872 G/C cg02336364 chr1:24764700 NIPAL3 0.34 6.94 0.39 2.96e-11 Response to interferon beta in multiple sclerosis; CESC cis rs7107174 0.901 rs2450133 chr11:77925759 A/C cg02023728 chr11:77925099 USP35 0.47 6.43 0.37 5.9e-10 Testicular germ cell tumor; CESC cis rs7809950 1.000 rs10276604 chr7:107216738 C/T cg23024343 chr7:107201750 COG5 0.43 5.56 0.32 6.71e-8 Coronary artery disease; CESC cis rs6446731 0.614 rs7661630 chr4:3280106 G/A cg08886695 chr4:3369023 RGS12 -0.37 -5.38 -0.31 1.65e-7 Mean platelet volume; CESC cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg07507251 chr3:52567010 NT5DC2 0.36 6.15 0.35 2.88e-9 Electroencephalogram traits; CESC cis rs7917772 0.582 rs4919663 chr10:104363293 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 5.66 0.33 4.02e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg16928487 chr17:17741425 SREBF1 -0.56 -9.44 -0.5 1.99e-18 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15888741 chr10:15139207 RPP38;C10orf111 0.6 6.8 0.39 7.05e-11 Gut microbiome composition (summer); CESC cis rs2637266 0.783 rs58247832 chr10:78471383 C/A cg18941641 chr10:78392320 NA 0.43 8.19 0.45 1.08e-14 Pulmonary function; CESC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg15369054 chr17:80825471 TBCD 0.53 7.29 0.41 3.57e-12 Breast cancer; CESC cis rs735396 1.000 rs1169309 chr12:121439192 G/T cg02403541 chr12:121454288 C12orf43 0.64 9.18 0.49 1.23e-17 N-glycan levels; CESC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg08888203 chr3:10149979 C3orf24 0.51 6.39 0.37 7.29e-10 Alzheimer's disease; CESC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg22433210 chr17:43662623 NA -0.91 -10.77 -0.55 1.15e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg00750074 chr16:89608354 SPG7 -0.37 -5.41 -0.32 1.41e-7 Multiple myeloma (IgH translocation); CESC cis rs826838 0.678 rs11182781 chr12:38610178 C/T cg26384229 chr12:38710491 ALG10B 0.74 11.15 0.57 6.39e-24 Heart rate; CESC cis rs4664304 0.629 rs955388 chr2:160837921 A/G cg03641300 chr2:160917029 PLA2R1 -0.44 -6.02 -0.35 5.73e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs6912958 0.559 rs107689 chr6:88069333 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.48 8.61 0.47 6.58e-16 Monocyte percentage of white cells; CESC cis rs28374715 0.578 rs72739630 chr15:41631064 G/A cg18705301 chr15:41695430 NDUFAF1 -1.07 -15.8 -0.7 4.43e-40 Ulcerative colitis; CESC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg18769074 chr3:133464867 TF 0.32 5.93 0.34 9.22e-9 Iron status biomarkers; CESC cis rs61776719 0.520 rs12569027 chr1:38449163 C/T cg26398791 chr1:38455867 SF3A3 -0.43 -5.46 -0.32 1.12e-7 Coronary artery disease; CESC cis rs35110281 0.508 rs2838351 chr21:45110784 A/G cg21573476 chr21:45109991 RRP1B -0.55 -7.78 -0.43 1.67e-13 Mean corpuscular volume; CESC cis rs80282103 0.764 rs12247818 chr10:1110464 G/A cg08668510 chr10:1095578 IDI1 0.65 5.53 0.32 7.75e-8 Glomerular filtration rate (creatinine); CESC cis rs12618769 0.571 rs72821939 chr2:99138872 T/C cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 6.54 0.37 3.08e-10 Personality dimensions; CESC cis rs4460629 0.742 rs7368345 chr1:155080090 C/T cg01019262 chr1:155095195 NA 0.29 5.15 0.3 5.14e-7 Serum magnesium levels; CESC cis rs2235544 0.554 rs7540270 chr1:54484682 A/G cg25741118 chr1:54482237 LDLRAD1 -0.23 -5.77 -0.33 2.16e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs1799949 0.965 rs4793234 chr17:41436183 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.83 0.48 1.48e-16 Menopause (age at onset); CESC cis rs897984 0.806 rs8050588 chr16:30937799 G/A cg02466173 chr16:30829666 NA -0.48 -8.23 -0.45 8.48e-15 Dementia with Lewy bodies; CESC cis rs8072100 0.713 rs1912486 chr17:45515167 A/G cg08085267 chr17:45401833 C17orf57 -0.52 -6.6 -0.38 2.28e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9815354 1.000 rs9856088 chr3:41860482 G/T cg03022575 chr3:42003672 ULK4 0.45 5.06 0.3 7.71e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7582720 0.943 rs72932556 chr2:203845996 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7727544 0.606 rs17622208 chr5:131717050 G/A cg14196790 chr5:131705035 SLC22A5 0.37 5.63 0.33 4.49e-8 Blood metabolite levels; CESC cis rs6762 0.550 rs8672 chr11:838634 C/G cg15787769 chr11:842744 TSPAN4;POLR2L -0.67 -8.65 -0.47 5.21e-16 Mean platelet volume; CESC cis rs977987 0.806 rs35263058 chr16:75391937 T/C cg03315344 chr16:75512273 CHST6 0.39 5.64 0.33 4.36e-8 Dupuytren's disease; CESC cis rs7662987 1.000 rs13125919 chr4:99999848 C/T cg13256891 chr4:100009986 ADH5 -0.83 -5.87 -0.34 1.29e-8 Smoking initiation; CESC cis rs9308731 1.000 rs1980045 chr2:111904541 A/G cg04202892 chr2:111875749 ACOXL 0.37 5.34 0.31 1.97e-7 Chronic lymphocytic leukemia; CESC cis rs4595586 0.545 rs969468 chr12:39367278 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs12477438 0.798 rs13409996 chr2:99575497 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.59 -0.55 4.26e-22 Chronic sinus infection; CESC cis rs826838 0.967 rs826856 chr12:39115434 G/A cg26384229 chr12:38710491 ALG10B -0.67 -11.02 -0.56 1.72e-23 Heart rate; CESC cis rs8077889 0.917 rs72836559 chr17:41913529 C/T cg26893861 chr17:41843967 DUSP3 0.83 9.9 0.52 7.45e-20 Triglycerides; CESC cis rs9914988 0.887 rs12451790 chr17:27112000 C/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC trans rs916888 0.610 rs199529 chr17:44837217 A/C cg07870213 chr5:140052090 DND1 0.53 6.43 0.37 5.85e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7412746 0.611 rs3768018 chr1:150723747 T/C cg04414720 chr1:150670196 GOLPH3L 0.57 7.47 0.42 1.14e-12 Melanoma; CESC cis rs8067354 0.645 rs28516945 chr17:57816578 T/C cg13753209 chr17:57696993 CLTC 0.65 7.77 0.43 1.71e-13 Hemoglobin concentration; CESC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg17372223 chr3:52568218 NT5DC2 0.4 6.01 0.35 6.27e-9 Electroencephalogram traits; CESC cis rs7539624 0.588 rs12070364 chr1:223916059 A/T cg10100437 chr1:223903862 CAPN2 0.38 5.09 0.3 6.88e-7 Schizophrenia; CESC cis rs2180341 1.000 rs9321073 chr6:127609691 C/T cg27446573 chr6:127587934 RNF146 1.08 16.13 0.7 3.14e-41 Breast cancer; CESC cis rs11920090 0.860 rs55641619 chr3:170740599 A/G cg09710316 chr3:170744871 SLC2A2 0.45 5.41 0.32 1.42e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs28647808 1.000 rs28556828 chr9:136273106 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.74 0.33 2.53e-8 Blood protein levels; CESC cis rs2070488 1.000 rs2268758 chr3:38514049 C/T cg24069376 chr3:38537580 EXOG 0.48 8.77 0.47 2.26e-16 Electrocardiographic conduction measures; CESC trans rs2727020 0.553 rs61904166 chr11:49581461 T/C cg03929089 chr4:120376271 NA -0.81 -12.18 -0.6 2.06e-27 Coronary artery disease; CESC cis rs12410462 0.681 rs58496521 chr1:227582375 T/C cg23173402 chr1:227635558 NA 0.65 5.73 0.33 2.74e-8 Major depressive disorder; CESC cis rs1729951 0.575 rs10935213 chr3:136693459 A/G cg04103450 chr3:136751342 NA 0.41 5.48 0.32 9.82e-8 Neuroticism; CESC cis rs9611565 0.512 rs4512 chr22:42206084 G/C cg17376030 chr22:41985996 PMM1 0.79 8.09 0.44 2.22e-14 Vitiligo; CESC cis rs7592578 0.882 rs2192010 chr2:191462133 C/T cg27211696 chr2:191398769 TMEM194B -0.62 -5.47 -0.32 1.06e-7 Diastolic blood pressure; CESC cis rs9611565 0.592 rs12484254 chr22:41962003 T/A cg17376030 chr22:41985996 PMM1 0.53 5.88 0.34 1.25e-8 Vitiligo; CESC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg18404041 chr3:52824283 ITIH1 -0.45 -7.34 -0.41 2.64e-12 Bipolar disorder; CESC cis rs1008375 0.863 rs2058336 chr4:17608299 T/C cg16339924 chr4:17578868 LAP3 0.64 8.22 0.45 9.39e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs66573146 0.831 rs67315413 chr4:6987910 T/C cg00086871 chr4:6988644 TBC1D14 1.18 8.17 0.45 1.25e-14 Granulocyte percentage of myeloid white cells; CESC cis rs611744 0.560 rs58605513 chr8:109279122 A/C cg21045802 chr8:109455806 TTC35 0.45 5.56 0.32 6.42e-8 Dupuytren's disease; CESC cis rs10479542 0.929 rs10078796 chr5:178978883 T/A cg21226059 chr5:178986404 RUFY1 0.5 7.62 0.42 4.49e-13 Lung cancer; CESC cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.21e-14 Blood protein levels; CESC cis rs9486719 0.843 rs2499796 chr6:96848364 A/G cg06623918 chr6:96969491 KIAA0776 0.75 7.16 0.4 8.08e-12 Migraine;Coronary artery disease; CESC cis rs7044106 0.791 rs10985001 chr9:123484232 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.34 5.55 0.32 6.77e-8 Hip circumference adjusted for BMI; CESC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg13047869 chr3:10149882 C3orf24 0.4 5.03 0.3 8.89e-7 Alzheimer's disease; CESC cis rs9457247 0.508 rs9459874 chr6:167504127 A/G cg23791538 chr6:167370224 RNASET2 0.43 5.71 0.33 3.06e-8 Crohn's disease; CESC cis rs2236918 0.710 rs2526698 chr1:242029101 T/C cg17736920 chr1:242011382 EXO1 0.55 6.97 0.39 2.51e-11 Menopause (age at onset); CESC cis rs7726839 0.561 rs11955068 chr5:582324 C/T cg09021430 chr5:549028 NA -0.43 -5.76 -0.33 2.29e-8 Obesity-related traits; CESC cis rs561341 0.882 rs563539 chr17:30307958 A/G cg12193833 chr17:30244370 NA -0.57 -5.73 -0.33 2.69e-8 Hip circumference adjusted for BMI; CESC cis rs2228479 0.850 rs62054611 chr16:89817017 T/C cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.67 8.75 0.47 2.62e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs977987 0.806 rs4887818 chr16:75361995 T/C cg03315344 chr16:75512273 CHST6 0.39 5.58 0.32 5.89e-8 Dupuytren's disease; CESC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg09877947 chr5:131593287 PDLIM4 0.46 5.98 0.35 7.05e-9 Breast cancer; CESC cis rs35306767 0.714 rs66797613 chr10:1090469 C/T cg26597838 chr10:835615 NA 0.63 6.0 0.35 6.62e-9 Eosinophil percentage of granulocytes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25237692 chr15:64752785 NA -0.47 -6.15 -0.35 2.9e-9 Ulcerative colitis; CESC cis rs7712401 0.601 rs154496 chr5:122221731 A/G cg19412675 chr5:122181750 SNX24 0.41 5.15 0.3 5.03e-7 Mean platelet volume; CESC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg22823121 chr1:150693482 HORMAD1 -0.42 -5.69 -0.33 3.38e-8 Urate levels; CESC cis rs1865721 0.771 rs6566093 chr18:73136682 T/C cg26385618 chr18:73139727 C18orf62 -0.51 -8.36 -0.46 3.47e-15 Intelligence; CESC cis rs763121 0.853 rs2267395 chr22:39113903 C/T cg06022373 chr22:39101656 GTPBP1 0.94 18.18 0.75 1.61e-48 Menopause (age at onset); CESC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg07936489 chr17:37558343 FBXL20 0.76 10.71 0.55 1.83e-22 Glomerular filtration rate (creatinine); CESC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg07936489 chr17:37558343 FBXL20 0.75 10.23 0.53 6.6e-21 Glomerular filtration rate (creatinine); CESC cis rs7512552 0.582 rs834233 chr1:150354276 G/A cg15654264 chr1:150340011 RPRD2 0.4 5.21 0.3 3.83e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC trans rs13063635 0.915 rs75928798 chr3:45962603 A/G cg10236987 chr1:228114221 WNT9A 0.56 6.05 0.35 4.83e-9 Eosinophil percentage of granulocytes; CESC cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg12386194 chr3:101231763 SENP7 0.58 6.6 0.38 2.25e-10 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.853 rs2267393 chr22:39101619 G/C cg06022373 chr22:39101656 GTPBP1 0.94 17.57 0.73 2.32e-46 Menopause (age at onset); CESC cis rs7520050 0.966 rs7539932 chr1:46292354 C/T cg24296786 chr1:45957014 TESK2 0.42 5.39 0.31 1.6e-7 Red blood cell count;Reticulocyte count; CESC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.39 0.31 1.54e-7 Bipolar disorder; CESC cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg21573476 chr21:45109991 RRP1B -0.53 -8.0 -0.44 3.92e-14 Mean corpuscular volume; CESC cis rs7107174 1.000 rs2510049 chr11:77985459 G/T cg02023728 chr11:77925099 USP35 0.48 6.63 0.38 1.82e-10 Testicular germ cell tumor; CESC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 12.95 0.62 4.82e-30 Platelet count; CESC cis rs10242455 0.702 rs73711293 chr7:99081595 C/T cg25640893 chr7:99214727 ZNF498 0.76 5.39 0.31 1.58e-7 Blood metabolite levels; CESC cis rs2439831 0.850 rs28718261 chr15:44043793 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.7 8.06 0.44 2.56e-14 Lung cancer in ever smokers; CESC trans rs7618501 0.933 rs1128535 chr3:49866392 C/T cg21659725 chr3:3221576 CRBN 0.84 13.68 0.64 1.39e-32 Intelligence (multi-trait analysis); CESC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg01341218 chr17:43662625 NA 0.92 10.78 0.55 1.06e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs62408225 1.000 rs62408225 chr6:90956409 A/G cg06866423 chr6:90926672 BACH2 0.46 5.67 0.33 3.74e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg00031303 chr3:195681400 NA 0.47 6.26 0.36 1.52e-9 Pancreatic cancer; CESC cis rs1395 0.778 rs72810794 chr2:27401260 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 5.5 0.32 8.91e-8 Blood metabolite levels; CESC cis rs7927771 0.524 rs10838746 chr11:47706291 A/G cg18512352 chr11:47633146 NA 0.35 5.39 0.31 1.53e-7 Subjective well-being; CESC cis rs4835473 0.838 rs6832094 chr4:144716541 A/C cg25736465 chr4:144833511 NA -0.35 -5.83 -0.34 1.59e-8 Immature fraction of reticulocytes; CESC cis rs6542838 0.611 rs17758170 chr2:99531842 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -5.84 -0.34 1.55e-8 Fear of minor pain; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00046018 chr1:202318086 PPP1R12B -0.52 -6.21 -0.36 2.03e-9 Ulcerative colitis; CESC cis rs1670533 1.000 rs629261 chr4:1086763 A/C cg04106633 chr4:1044584 NA 0.4 5.08 0.3 6.98e-7 Recombination rate (females); CESC cis rs708547 0.836 rs1718882 chr4:57859533 C/G cg14719990 chr4:57843890 C4orf14;POLR2B 0.47 5.63 0.33 4.58e-8 Response to bleomycin (chromatid breaks); CESC cis rs6570726 0.935 rs425731 chr6:145834151 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.934 rs430003 chr6:145819506 C/T cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.71 -0.33 2.98e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7771547 0.573 rs522179 chr6:36391605 G/A cg07856975 chr6:36356162 ETV7 0.37 5.5 0.32 8.73e-8 Platelet distribution width; CESC cis rs7772486 0.875 rs2474353 chr6:146323883 G/A cg05347473 chr6:146136440 FBXO30 0.53 6.87 0.39 4.54e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg17143192 chr8:8559678 CLDN23 0.75 8.46 0.46 1.78e-15 Obesity-related traits; CESC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.05 10.71 0.55 1.78e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19452060 chr12:57914632 DDIT3 -0.42 -6.71 -0.38 1.19e-10 Gambling; CESC cis rs3126085 0.935 rs1858478 chr1:152257457 C/T cg03465714 chr1:152285911 FLG 0.45 5.54 0.32 7.12e-8 Atopic dermatitis; CESC cis rs11969893 0.737 rs1856131 chr6:101407104 C/G cg12253828 chr6:101329408 ASCC3 0.89 7.23 0.41 5.04e-12 Economic and political preferences (immigration/crime); CESC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12956009 0.518 rs1347343 chr18:44818996 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.47 6.24 0.36 1.73e-9 Educational attainment (years of education); CESC trans rs10242455 0.557 rs45492501 chr7:99047030 T/A cg09045935 chr12:6379348 NA 0.91 7.33 0.41 2.87e-12 Blood metabolite levels; CESC cis rs763121 0.853 rs4821808 chr22:39065739 A/G cg06022373 chr22:39101656 GTPBP1 0.88 13.81 0.65 4.88e-33 Menopause (age at onset); CESC cis rs2708240 1.000 rs2538990 chr7:147580041 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 0.36 5.92 0.34 1.01e-8 QT interval (drug interaction); CESC cis rs3741798 1.000 rs61922023 chr12:12485555 G/A cg08615371 chr12:12503544 MANSC1 0.87 6.35 0.36 9.19e-10 Cerebrospinal fluid biomarker levels; CESC cis rs9309473 0.500 rs12472502 chr2:73859184 C/T cg20560298 chr2:73613845 ALMS1 0.51 7.14 0.4 8.9e-12 Metabolite levels; CESC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.07 0.53 2.08e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23709988 chr14:23772096 PPP1R3E -0.46 -6.42 -0.37 6.15e-10 Fibrinogen levels; CESC cis rs1707322 0.656 rs3014210 chr1:46066608 A/G cg06784218 chr1:46089804 CCDC17 -0.43 -7.66 -0.43 3.41e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7726839 0.540 rs3762951 chr5:662613 C/G cg09021430 chr5:549028 NA -0.4 -5.04 -0.3 8.51e-7 Obesity-related traits; CESC cis rs7086627 0.506 rs10749575 chr10:82136921 C/T cg00277334 chr10:82204260 NA -0.52 -7.67 -0.43 3.38e-13 Post bronchodilator FEV1; CESC trans rs208520 0.955 rs208532 chr6:66961280 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -9.42 -0.5 2.36e-18 Exhaled nitric oxide output; CESC cis rs858239 0.601 rs10278700 chr7:23160529 T/C cg23682824 chr7:23144976 KLHL7 0.54 7.38 0.41 2.09e-12 Cerebrospinal fluid biomarker levels; CESC cis rs4948102 0.924 rs13240915 chr7:56090752 G/C cg09872392 chr7:56161020 PHKG1 -0.4 -6.15 -0.35 2.9e-9 Plasma homocysteine levels (post-methionine load test); CESC cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg16339924 chr4:17578868 LAP3 0.75 9.8 0.52 1.56e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4664308 0.618 rs62175488 chr2:160892758 T/C cg03641300 chr2:160917029 PLA2R1 -0.59 -8.54 -0.46 1.04e-15 Idiopathic membranous nephropathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07589846 chr1:212872696 BATF3 0.53 6.36 0.36 8.95e-10 Gut microbiome composition (summer); CESC cis rs78456975 1.000 rs11898988 chr2:1560336 G/A cg26248373 chr2:1572462 NA -0.59 -5.7 -0.33 3.11e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs2625529 0.761 rs972029 chr15:72172986 C/T cg16672083 chr15:72433130 SENP8 -0.37 -5.05 -0.3 8.12e-7 Red blood cell count; CESC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg02951883 chr7:2050386 MAD1L1 -0.49 -6.59 -0.38 2.32e-10 Bipolar disorder and schizophrenia; CESC cis rs829883 0.621 rs11109516 chr12:98921035 G/A cg25150519 chr12:98850993 NA -0.64 -7.93 -0.44 6.24e-14 Colorectal adenoma (advanced); CESC cis rs2295499 0.782 rs4690053 chr4:2736579 G/C cg08330972 chr4:2403930 ZFYVE28 -0.33 -5.21 -0.3 3.89e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04122601 chr12:10826785 STYK1 0.46 6.13 0.35 3.17e-9 Gut microbiota (bacterial taxa); CESC cis rs6723226 0.803 rs176415 chr2:32649778 G/A cg02381751 chr2:32503542 YIPF4 -0.81 -11.7 -0.58 8.87e-26 Intelligence (multi-trait analysis); CESC cis rs34734847 0.703 rs7978125 chr12:121167039 A/G cg21892295 chr12:121157589 UNC119B -0.35 -5.6 -0.33 5.48e-8 Mean corpuscular volume; CESC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.35 -6.13 -0.35 3.13e-9 Bipolar disorder; CESC cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg17427002 chr7:12443146 VWDE -0.53 -5.08 -0.3 7.29e-7 Coronary artery disease; CESC cis rs6540559 0.546 rs735694 chr1:210034029 T/C cg21951975 chr1:209979733 IRF6 0.58 6.23 0.36 1.85e-9 Cleft lip with or without cleft palate; CESC cis rs1784581 0.588 rs4131681 chr6:162422167 T/G cg17173639 chr6:162384350 PARK2 0.57 8.73 0.47 2.94e-16 Itch intensity from mosquito bite; CESC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg00339695 chr16:24857497 SLC5A11 -0.5 -6.57 -0.37 2.58e-10 Intelligence (multi-trait analysis); CESC cis rs4727963 0.846 rs7805573 chr7:122699114 C/T cg03640110 chr7:122635026 TAS2R16 -0.37 -5.71 -0.33 3.07e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg19774624 chr17:42201019 HDAC5 0.68 9.64 0.51 4.82e-19 Total body bone mineral density; CESC cis rs412050 0.594 rs113463481 chr22:22097230 G/A cg17089214 chr22:22089827 YPEL1 0.65 5.63 0.33 4.49e-8 Attention deficit hyperactivity disorder; CESC cis rs9796 0.653 rs28516683 chr15:41446645 A/G cg20272979 chr15:41787780 ITPKA 0.34 5.12 0.3 6.01e-7 Menopause (age at onset); CESC cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg05340658 chr4:99064831 C4orf37 0.64 8.22 0.45 9.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs68170813 0.559 rs58663672 chr7:106949444 T/C cg02696742 chr7:106810147 HBP1 -0.54 -5.12 -0.3 5.86e-7 Coronary artery disease; CESC cis rs879620 1.000 rs2531995 chr16:4013467 C/T cg09300795 chr16:4042428 ADCY9 0.38 5.14 0.3 5.39e-7 Hip circumference;Body mass index; CESC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg11890956 chr21:40555474 PSMG1 -0.63 -8.81 -0.48 1.69e-16 Menarche (age at onset); CESC cis rs9649465 0.967 rs12706546 chr7:123353414 G/A cg04330084 chr7:123175371 IQUB -0.39 -5.23 -0.31 3.37e-7 Migraine; CESC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg11890956 chr21:40555474 PSMG1 1.18 23.98 0.83 2.35e-68 Cognitive function; CESC cis rs12971120 0.891 rs4891557 chr18:72170299 C/T cg25817165 chr18:72167213 CNDP2 -0.61 -7.26 -0.41 4.39e-12 Refractive error; CESC cis rs7512552 0.839 rs834232 chr1:150354682 T/C cg15654264 chr1:150340011 RPRD2 0.39 5.25 0.31 3.16e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs4604732 0.642 rs10802514 chr1:247637749 A/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.4 5.97 0.34 7.41e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9488822 0.676 rs11153593 chr6:116335131 C/A cg18764771 chr6:116381957 FRK 0.22 5.42 0.32 1.32e-7 Cholesterol, total;LDL cholesterol; CESC cis rs4144743 1.000 rs4144743 chr17:45323125 A/G cg18085866 chr17:45331354 ITGB3 -0.66 -7.69 -0.43 2.84e-13 Body mass index; CESC cis rs2120019 1.000 rs67544533 chr15:75361539 A/G cg09165964 chr15:75287851 SCAMP5 -0.74 -8.79 -0.48 1.9e-16 Blood trace element (Zn levels); CESC cis rs300703 0.748 rs4484059 chr2:286812 G/A cg21211680 chr2:198530 NA 0.85 7.25 0.41 4.51e-12 Blood protein levels; CESC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs3806843 0.900 rs2531340 chr5:140131046 C/T cg26395211 chr5:140044315 WDR55 0.39 5.09 0.3 6.79e-7 Depressive symptoms (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21367838 chr20:47805154 STAU1 -0.41 -6.23 -0.36 1.79e-9 Gambling; CESC cis rs1620921 0.505 rs13196324 chr6:161201842 A/T cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC trans rs2273788 1.000 rs2273788 chr9:114348617 C/T cg24992690 chr2:160472234 BAZ2B -0.57 -6.12 -0.35 3.27e-9 Monocyte count; CESC cis rs72945132 0.825 rs7950280 chr11:70213455 G/T cg00319359 chr11:70116639 PPFIA1 0.68 6.63 0.38 1.86e-10 Coronary artery disease; CESC cis rs11122272 0.668 rs2749712 chr1:231537751 T/A cg06096015 chr1:231504339 EGLN1 0.43 6.08 0.35 4.07e-9 Hemoglobin concentration; CESC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 11.71 0.58 8.2e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg18876405 chr7:65276391 NA 0.69 9.69 0.51 3.26e-19 Aortic root size; CESC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.62 0.33 4.73e-8 Personality dimensions; CESC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg11766577 chr21:47581405 C21orf56 -0.43 -5.94 -0.34 8.84e-9 Testicular germ cell tumor; CESC cis rs6963495 0.799 rs73190201 chr7:105165891 A/C cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs1707322 0.964 rs785496 chr1:46588006 T/C cg06784218 chr1:46089804 CCDC17 -0.36 -5.93 -0.34 9.35e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8063761 0.689 rs4785763 chr16:90066936 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.59 -7.32 -0.41 3.01e-12 Squamous cell carcinoma; CESC cis rs7216064 0.953 rs1966410 chr17:65837215 T/C cg07042672 chr17:66097459 LOC651250 -0.57 -6.69 -0.38 1.32e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1008375 0.902 rs12503164 chr4:17656107 C/T cg16339924 chr4:17578868 LAP3 0.56 7.01 0.4 1.96e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2070488 0.804 rs1817364 chr3:38474513 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 13.18 0.63 7.62e-31 Electrocardiographic conduction measures; CESC cis rs854765 0.583 rs10048206 chr17:17866897 A/G cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg26597838 chr10:835615 NA 0.91 9.69 0.51 3.43e-19 Eosinophil percentage of granulocytes; CESC cis rs4919694 1.000 rs12257941 chr10:104833161 C/T cg04362960 chr10:104952993 NT5C2 0.79 7.0 0.4 2.07e-11 Arsenic metabolism; CESC cis rs1344694 0.566 rs13029765 chr2:216894976 A/T cg12620499 chr2:216877984 MREG 0.57 8.08 0.44 2.34e-14 Alcohol dependence; CESC cis rs11264213 0.901 rs72661605 chr1:36326227 A/G cg27506609 chr1:36549197 TEKT2 0.66 5.59 0.32 5.58e-8 Schizophrenia; CESC cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg08859206 chr1:53392774 SCP2 0.6 7.75 0.43 1.96e-13 Monocyte count; CESC trans rs1448094 0.692 rs7958438 chr12:86326141 A/T cg00308659 chr16:84871952 CRISPLD2 0.46 6.15 0.35 2.87e-9 Major depressive disorder; CESC cis rs1801251 1.000 rs4517962 chr2:233578337 T/C cg25237894 chr2:233734115 C2orf82 0.48 8.11 0.45 1.86e-14 Coronary artery disease; CESC cis rs3020736 0.519 rs5996116 chr22:42517492 G/A cg04733989 chr22:42467013 NAGA -0.78 -11.9 -0.59 1.87e-26 Autism spectrum disorder or schizophrenia; CESC cis rs77956314 0.515 rs12299065 chr12:117442304 A/G cg25972092 chr12:117363249 FBXW8 0.53 5.85 0.34 1.46e-8 Subcortical brain region volumes;Hippocampal volume; CESC cis rs748404 0.631 rs8042688 chr15:43638525 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.69 0.47 3.96e-16 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07474076 chr16:2972993 FLYWCH1 -0.67 -7.51 -0.42 9.12e-13 Gut microbiome composition (summer); CESC cis rs8180040 0.934 rs4858811 chr3:47480524 G/C cg27129171 chr3:47204927 SETD2 -0.63 -9.47 -0.5 1.61e-18 Colorectal cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16259330 chr11:13299070 ARNTL -0.47 -6.01 -0.35 6.02e-9 Fibrinogen levels; CESC cis rs16854884 0.586 rs11914731 chr3:143725594 A/G cg06585982 chr3:143692056 C3orf58 0.52 7.07 0.4 1.42e-11 Economic and political preferences (feminism/equality); CESC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg23978390 chr7:1156363 C7orf50 0.57 7.84 0.43 1.1e-13 Longevity;Endometriosis; CESC cis rs9291683 0.546 rs6829727 chr4:10051672 A/C cg00071950 chr4:10020882 SLC2A9 0.77 12.81 0.62 1.51e-29 Bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12504415 chr17:74722752 JMJD6;C17orf95 -0.45 -6.21 -0.36 2.03e-9 Fibrinogen levels; CESC cis rs17253792 0.822 rs75288952 chr14:56034010 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.83 5.5 0.32 8.98e-8 Putamen volume; CESC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg09263875 chr16:632152 PIGQ 0.68 11.68 0.58 1.06e-25 Height; CESC trans rs1382269 0.866 rs3856624 chr3:136997294 C/T cg16900796 chr19:10755136 SLC44A2 -0.4 -6.09 -0.35 4.05e-9 Metabolite levels; CESC cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg24920358 chr1:40204285 PPIE 0.43 6.41 0.37 6.57e-10 Blood protein levels; CESC cis rs926938 0.584 rs869990 chr1:115379614 A/G cg12756093 chr1:115239321 AMPD1 -0.45 -6.13 -0.35 3.15e-9 Autism; CESC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg23281280 chr6:28129359 ZNF389 0.52 7.0 0.39 2.13e-11 Parkinson's disease; CESC cis rs6466055 0.720 rs4730082 chr7:105027509 A/G cg04380332 chr7:105027541 SRPK2 -0.42 -5.6 -0.33 5.42e-8 Schizophrenia; CESC cis rs7264396 0.790 rs2425160 chr20:34425968 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -11.14 -0.56 6.75e-24 Total cholesterol levels; CESC cis rs546131 0.928 rs499183 chr11:34836678 A/G cg06937548 chr11:34938143 PDHX;APIP 0.51 6.3 0.36 1.24e-9 Lung disease severity in cystic fibrosis; CESC cis rs4835473 0.897 rs7676614 chr4:144616366 A/G cg25736465 chr4:144833511 NA -0.42 -6.22 -0.36 1.95e-9 Immature fraction of reticulocytes; CESC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg22800045 chr5:56110881 MAP3K1 0.81 9.66 0.51 4.1e-19 Initial pursuit acceleration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01370599 chr3:116745421 NA -0.41 -6.5 -0.37 3.86e-10 Gut microbiota (bacterial taxa); CESC cis rs4803468 0.967 rs67047091 chr19:41938684 C/T cg08639244 chr19:41945921 ATP5SL 0.44 5.41 0.32 1.39e-7 Height; CESC cis rs7684253 0.565 rs7697176 chr4:57823048 C/T cg21154227 chr4:57904332 IGFBP7 0.37 5.36 0.31 1.85e-7 Migraine; CESC cis rs2072732 0.861 rs4576609 chr1:2938265 C/T cg03976712 chr1:2946727 NA 0.34 5.39 0.31 1.58e-7 Plateletcrit; CESC cis rs921968 0.565 rs2059717 chr2:219600316 A/T cg02176678 chr2:219576539 TTLL4 -0.4 -7.04 -0.4 1.67e-11 Mean corpuscular hemoglobin concentration; CESC cis rs67460515 0.892 rs2100238 chr3:161058055 T/A cg03342759 chr3:160939853 NMD3 -0.54 -7.82 -0.43 1.29e-13 Parkinson's disease; CESC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg03806693 chr22:41940476 POLR3H 1.16 14.45 0.66 2.63e-35 Vitiligo; CESC cis rs6831352 1.000 rs1126670 chr4:100052733 C/A cg13256891 chr4:100009986 ADH5 0.72 8.45 0.46 1.94e-15 Alcohol dependence; CESC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg11890956 chr21:40555474 PSMG1 1.19 23.55 0.82 6.33e-67 Cognitive function; CESC cis rs9790314 1.000 rs28515190 chr3:161028605 G/A cg04691961 chr3:161091175 C3orf57 -0.45 -5.81 -0.34 1.75e-8 Morning vs. evening chronotype; CESC cis rs7178909 0.902 rs8034116 chr15:90441568 A/G cg19708238 chr15:90437601 AP3S2 0.45 6.41 0.37 6.78e-10 Common traits (Other); CESC cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg06484146 chr7:12443880 VWDE -0.79 -9.25 -0.49 7.67e-18 Coronary artery disease; CESC cis rs61931739 0.500 rs11053272 chr12:34547020 C/G cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs7937682 0.632 rs11608193 chr11:111732215 T/C cg09085632 chr11:111637200 PPP2R1B 0.87 10.76 0.55 1.25e-22 Primary sclerosing cholangitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04179819 chr10:7860513 TAF3 -0.39 -6.2 -0.36 2.1e-9 Gambling; CESC cis rs4237845 0.537 rs12426201 chr12:58259752 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.5 5.57 0.32 6.28e-8 Intelligence (multi-trait analysis); CESC cis rs314370 0.951 rs12667888 chr7:100474289 T/C cg10426581 chr7:100472382 SRRT 0.86 8.37 0.46 3.32e-15 Resting heart rate; CESC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg25036284 chr2:26402008 FAM59B -0.71 -8.2 -0.45 1.05e-14 Gut microbiome composition (summer); CESC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.55 -7.36 -0.41 2.37e-12 Menarche (age at onset); CESC cis rs7208859 0.623 rs9895785 chr17:29107708 C/T cg19761014 chr17:28927070 LRRC37B2 -0.78 -6.45 -0.37 5.34e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8177179 0.967 rs4994582 chr3:133437566 G/C cg16262614 chr3:133464971 TF 0.38 7.36 0.41 2.37e-12 Iron status biomarkers (transferrin levels); CESC cis rs4141404 0.740 rs9609301 chr22:31895940 C/T cg13145458 chr22:31556086 RNF185 -0.53 -6.25 -0.36 1.63e-9 Paclitaxel-induced neuropathy; CESC cis rs2228479 0.850 rs62056068 chr16:89909737 C/T cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs7116495 1.000 rs7127865 chr11:71747781 G/C cg26138937 chr11:71823887 C11orf51 -0.82 -6.68 -0.38 1.39e-10 Severe influenza A (H1N1) infection; CESC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.53 -0.32 7.74e-8 Depression; CESC cis rs2243480 1.000 rs402418 chr7:65509469 G/A cg25894440 chr7:65020034 NA -0.61 -5.12 -0.3 5.79e-7 Diabetic kidney disease; CESC cis rs6032067 0.929 rs17424868 chr20:43818519 T/G cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.53e-7 Blood protein levels; CESC cis rs9811920 0.609 rs9872871 chr3:99658702 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.64 -10.15 -0.53 1.17e-20 Axial length; CESC cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 0.508 rs6902119 chr6:167505791 T/C cg07741184 chr6:167504864 NA 0.33 5.73 0.33 2.76e-8 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04683551 chr10:14880332 HSPA14;CDNF 0.55 6.52 0.37 3.58e-10 Gut microbiome composition (summer); CESC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg16132339 chr22:24313637 DDTL;DDT 0.37 5.55 0.32 7.05e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs8067342 0.611 rs6587132 chr17:21175069 C/T cg03858720 chr17:21194718 MAP2K3 0.42 5.7 0.33 3.21e-8 Immature fraction of reticulocytes;Red cell distribution width; CESC cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.44 7.24 0.41 4.8e-12 Personality dimensions; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12994003 chr1:225616475 LBR -0.45 -6.12 -0.35 3.27e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs71277158 0.688 rs16854812 chr3:169774383 T/C cg04067573 chr3:169899625 PHC3 0.56 5.73 0.33 2.73e-8 Prostate cancer; CESC cis rs9902453 0.934 rs11080120 chr17:28507021 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.84 0.43 1.09e-13 Coffee consumption (cups per day); CESC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg16606324 chr3:10149918 C3orf24 0.42 5.16 0.3 4.9e-7 Alzheimer's disease; CESC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg04414720 chr1:150670196 GOLPH3L -0.63 -9.01 -0.48 4.15e-17 Tonsillectomy; CESC cis rs7903847 0.642 rs6584128 chr10:99171926 G/T cg20016023 chr10:99160130 RRP12 0.3 5.04 0.3 8.75e-7 Granulocyte percentage of myeloid white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07791762 chr19:17323290 MYO9B 0.49 6.43 0.37 5.88e-10 Fibrinogen levels; CESC cis rs11098499 0.908 rs1002152 chr4:120273387 C/A cg24375607 chr4:120327624 NA 0.46 5.59 0.32 5.72e-8 Corneal astigmatism; CESC cis rs2625529 0.652 rs2899776 chr15:72268365 A/T cg16672083 chr15:72433130 SENP8 0.46 6.81 0.39 6.7e-11 Red blood cell count; CESC cis rs2243480 1.000 rs160646 chr7:65556280 C/T cg13147721 chr7:65941812 NA -0.98 -9.09 -0.49 2.37e-17 Diabetic kidney disease; CESC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg13628971 chr7:2884303 GNA12 0.63 8.14 0.45 1.53e-14 Height; CESC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg16145915 chr7:1198662 ZFAND2A -0.47 -6.48 -0.37 4.33e-10 Longevity;Endometriosis; CESC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg24578937 chr1:2090814 PRKCZ -0.34 -5.75 -0.33 2.46e-8 Height; CESC cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg15017067 chr4:17643749 FAM184B 0.4 5.69 0.33 3.38e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs7839040 0.698 rs7820074 chr8:82928598 T/C cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs2832077 1.000 rs9983229 chr21:30137674 A/G cg03476357 chr21:30257390 N6AMT1 0.53 5.79 0.33 2.02e-8 Cognitive test performance; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04005938 chr7:148334417 NA 0.49 6.42 0.37 6.15e-10 Fibrinogen levels; CESC trans rs10518765 0.945 rs35334291 chr15:54648780 C/G cg09098624 chr8:11558334 NA -0.56 -6.04 -0.35 5.13e-9 Select biomarker traits; CESC cis rs9911578 1.000 rs4482353 chr17:56896834 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.24 0.31 3.23e-7 Intelligence (multi-trait analysis); CESC cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg02574844 chr11:5959923 NA -0.44 -5.49 -0.32 9.52e-8 DNA methylation (variation); CESC cis rs12477438 0.520 rs36071868 chr2:99737120 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.09 0.7 4.08e-41 Chronic sinus infection; CESC cis rs116095464 0.614 rs4371799 chr5:268192 C/A cg20965017 chr5:231967 SDHA -0.46 -5.24 -0.31 3.34e-7 Breast cancer; CESC cis rs1538970 0.504 rs3790585 chr1:46023356 A/T cg05343316 chr1:45956843 TESK2 0.69 7.37 0.41 2.17e-12 Platelet count; CESC cis rs9902453 0.765 rs2729436 chr17:28120670 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg05234568 chr11:5960015 NA -0.45 -5.31 -0.31 2.27e-7 DNA methylation (variation); CESC cis rs6696846 0.703 rs112653854 chr1:205079251 G/T cg00857998 chr1:205179979 DSTYK 0.53 7.03 0.4 1.78e-11 Red blood cell count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05742564 chr16:23568708 UBFD1;EARS2 -0.42 -6.06 -0.35 4.66e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9914988 0.943 rs67327562 chr17:27108828 G/A cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC trans rs9929218 0.551 rs3785135 chr16:68728976 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.86 -14.02 -0.65 8.54e-34 Colorectal cancer; CESC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg19445457 chr11:5799446 OR52N5 -0.4 -5.41 -0.32 1.4e-7 DNA methylation (variation); CESC cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs3733585 0.699 rs1122142 chr4:9947548 G/C cg11266682 chr4:10021025 SLC2A9 -0.59 -11.16 -0.57 5.72e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3780486 0.846 rs913214 chr9:33135085 G/A cg13443165 chr9:33130375 B4GALT1 0.47 6.88 0.39 4.37e-11 IgG glycosylation; CESC cis rs17376456 1.000 rs17376456 chr5:93557702 C/T cg21475434 chr5:93447410 FAM172A -0.87 -7.24 -0.41 4.98e-12 Diabetic retinopathy; CESC cis rs78456975 0.550 rs11904276 chr2:1524006 T/C cg01028140 chr2:1542097 TPO -0.48 -6.09 -0.35 3.97e-9 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs6088580 0.634 rs2424992 chr20:33012060 C/T cg08999081 chr20:33150536 PIGU 0.65 11.43 0.57 7.54e-25 Glomerular filtration rate (creatinine); CESC trans rs853679 0.546 rs17695758 chr6:27837183 T/C cg01620082 chr3:125678407 NA -0.76 -6.48 -0.37 4.51e-10 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26520976 chr11:63706312 NAA40 0.55 6.03 0.35 5.57e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04769218 chr7:99098020 ZNF394 0.58 7.0 0.4 2.12e-11 Gut microbiome composition (summer); CESC cis rs35995292 0.534 rs13228087 chr7:38909204 A/C cg19327137 chr7:38886074 VPS41 0.63 10.43 0.54 1.4e-21 Subjective well-being (multi-trait analysis); CESC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg02018176 chr4:1364513 KIAA1530 0.43 6.18 0.36 2.36e-9 Longevity; CESC cis rs7267979 0.586 rs6050429 chr20:25183058 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.66 10.76 0.55 1.18e-22 Liver enzyme levels (alkaline phosphatase); CESC cis rs7020830 0.898 rs13284651 chr9:37222681 G/T cg14294708 chr9:37120828 ZCCHC7 -1.23 -22.06 -0.8 6.4e-62 Schizophrenia; CESC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg04944784 chr2:26401820 FAM59B -0.81 -8.98 -0.48 5.09e-17 Gut microbiome composition (summer); CESC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg06634786 chr22:41940651 POLR3H -0.63 -6.61 -0.38 2.1e-10 Vitiligo; CESC cis rs2898681 0.618 rs79471207 chr4:53738524 C/T cg00791764 chr4:53727839 RASL11B 0.55 5.36 0.31 1.79e-7 Optic nerve measurement (cup area); CESC cis rs2637266 0.703 rs12252157 chr10:78449521 G/A cg18941641 chr10:78392320 NA 0.4 7.27 0.41 4.01e-12 Pulmonary function; CESC trans rs3942852 0.915 rs905477 chr11:48148606 T/C cg15704280 chr7:45808275 SEPT13 -0.69 -7.79 -0.43 1.51e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs7465272 0.500 rs7463655 chr8:143731034 G/C cg10596483 chr8:143751796 JRK 0.42 5.33 0.31 2.06e-7 Bipolar disorder and schizophrenia; CESC cis rs2730245 0.645 rs4909282 chr7:158699797 T/C cg01943577 chr7:158741284 NA -0.46 -6.13 -0.35 3.16e-9 Height; CESC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.91 9.82 0.52 1.26e-19 Platelet count; CESC cis rs933688 1.000 rs1363839 chr5:90671274 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.12 16.02 0.7 7.64e-41 Smoking behavior; CESC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg00684032 chr4:1343700 KIAA1530 0.4 5.56 0.32 6.51e-8 Obesity-related traits; CESC cis rs2108622 0.727 rs8102532 chr19:15980060 G/A cg13772218 chr19:15982569 NA 0.3 5.78 0.33 2.11e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs9905704 0.918 rs304272 chr17:56803028 C/A cg12560992 chr17:57184187 TRIM37 0.59 7.01 0.4 1.92e-11 Testicular germ cell tumor; CESC cis rs7216064 1.000 rs62085993 chr17:65923152 T/C cg07042672 chr17:66097459 LOC651250 -0.54 -5.87 -0.34 1.3e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg17366294 chr4:99064904 C4orf37 0.58 8.3 0.45 5.45e-15 Colonoscopy-negative controls vs population controls; CESC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg00934597 chr7:893267 UNC84A 0.53 5.41 0.32 1.43e-7 Cerebrospinal P-tau181p levels; CESC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 9.88 0.52 8.25e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg27266027 chr21:40555129 PSMG1 -0.4 -5.13 -0.3 5.63e-7 Cognitive function; CESC cis rs10791097 0.694 rs2155749 chr11:130751094 G/T cg12179176 chr11:130786555 SNX19 0.65 10.24 0.53 6.07e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9308731 0.842 rs56173510 chr2:111928436 G/T cg04202892 chr2:111875749 ACOXL 0.35 5.04 0.3 8.53e-7 Chronic lymphocytic leukemia; CESC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg26850624 chr5:429559 AHRR -0.5 -6.67 -0.38 1.52e-10 Cystic fibrosis severity; CESC cis rs7927771 1.000 rs11039390 chr11:47796295 C/G cg18512352 chr11:47633146 NA -0.61 -9.59 -0.51 6.7e-19 Subjective well-being; CESC cis rs8072100 0.688 rs8079142 chr17:45442049 G/A cg08085267 chr17:45401833 C17orf57 -0.53 -6.65 -0.38 1.65e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg10691866 chr7:65817282 TPST1 0.31 5.06 0.3 7.76e-7 Aortic root size; CESC cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg09658497 chr7:2847517 GNA12 -0.34 -5.09 -0.3 6.75e-7 Height; CESC trans rs7615952 0.558 rs17334039 chr3:125540308 A/G cg07211511 chr3:129823064 LOC729375 -0.84 -9.55 -0.51 9.43e-19 Blood pressure (smoking interaction); CESC cis rs7647973 1.000 rs9871024 chr3:49554241 T/C cg02487422 chr3:49467188 NICN1 -0.41 -5.35 -0.31 1.86e-7 Menarche (age at onset); CESC cis rs7116495 0.609 rs6592457 chr11:71738086 G/C cg18441811 chr11:71824068 C11orf51 -0.86 -5.19 -0.3 4.21e-7 Severe influenza A (H1N1) infection; CESC cis rs9929218 1.000 rs8056538 chr16:68802282 C/T cg02972257 chr16:68554789 NA 0.45 5.47 0.32 1.03e-7 Colorectal cancer; CESC cis rs11229555 1.000 rs11229543 chr11:58370698 G/A cg15696309 chr11:58395628 NA -0.43 -5.64 -0.33 4.3e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs2011503 0.739 rs8108659 chr19:19680738 T/A cg11584989 chr19:19387371 SF4 -0.45 -5.03 -0.3 9.03e-7 Bipolar disorder; CESC cis rs9457247 1.000 rs393727 chr6:167398632 T/A cg23791538 chr6:167370224 RNASET2 -0.6 -8.59 -0.47 7.81e-16 Crohn's disease; CESC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg18876405 chr7:65276391 NA 0.53 7.06 0.4 1.42e-11 Aortic root size; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg15622891 chr6:163862445 QKI 0.39 6.01 0.35 5.97e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.721 rs56255771 chr1:46224319 C/T cg03146154 chr1:46216737 IPP 0.74 10.62 0.55 3.46e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7927771 0.524 rs7129797 chr11:47667167 G/C cg18512352 chr11:47633146 NA 0.34 5.18 0.3 4.49e-7 Subjective well-being; CESC cis rs79057730 0.599 rs9458 chr7:825494 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.88 -8.08 -0.44 2.33e-14 Initial pursuit acceleration; CESC cis rs12142240 0.738 rs10489769 chr1:46806703 A/G cg10495392 chr1:46806563 NSUN4 0.59 6.37 0.36 8.18e-10 Menopause (age at onset); CESC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.74 9.01 0.48 4.17e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs6968419 0.755 rs4730719 chr7:115895010 A/C cg02561103 chr7:115862891 TES 0.42 5.49 0.32 9.63e-8 Intraocular pressure; CESC cis rs17253792 0.822 rs2147114 chr14:56077118 C/T cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg26897989 chr16:1907736 C16orf73 -0.53 -6.52 -0.37 3.49e-10 Ankle injury; CESC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg23172400 chr8:95962367 TP53INP1 0.4 7.44 0.42 1.38e-12 Type 2 diabetes; CESC cis rs933688 0.938 rs6866923 chr5:90669352 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.2 17.43 0.73 7.37e-46 Smoking behavior; CESC cis rs17253792 0.822 rs80328469 chr14:56067701 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg22029157 chr1:209979665 IRF6 0.66 9.23 0.49 9.02e-18 Cleft lip with or without cleft palate; CESC cis rs9393777 0.623 rs9358944 chr6:26469875 A/C cg14345882 chr6:26364793 BTN3A2 0.43 5.43 0.32 1.3e-7 Intelligence (multi-trait analysis); CESC cis rs9399137 0.507 rs12663810 chr6:135289782 G/C cg24558204 chr6:135376177 HBS1L 0.7 9.52 0.5 1.13e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.51e-11 Developmental language disorder (linguistic errors); CESC cis rs9937943 0.667 rs11862508 chr16:74598688 T/C cg01733217 chr16:74700730 RFWD3 0.58 5.13 0.3 5.6e-7 Neutrophil percentage of white cells; CESC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg04166393 chr7:2884313 GNA12 0.57 7.27 0.41 4.13e-12 Height; CESC cis rs2228479 0.850 rs62054610 chr16:89816920 G/A cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs858239 0.539 rs6955969 chr7:23186699 C/T cg23682824 chr7:23144976 KLHL7 0.51 6.72 0.38 1.13e-10 Cerebrospinal fluid biomarker levels; CESC cis rs11677416 1.000 rs59674541 chr2:113553824 A/T cg27083787 chr2:113543245 IL1A 0.44 5.4 0.31 1.48e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs7605827 0.836 rs13019322 chr2:15511270 G/A cg19274914 chr2:15703543 NA 0.32 5.58 0.32 5.99e-8 Educational attainment (years of education); CESC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.59 0.64 2.77e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg26597838 chr10:835615 NA 0.85 9.43 0.5 2.16e-18 Eosinophil percentage of granulocytes; CESC cis rs7208859 0.623 rs1061346 chr17:29114229 G/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12464559 0.579 rs6740508 chr2:152613212 T/A cg01189475 chr2:152685088 ARL5A 0.68 5.87 0.34 1.31e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs2243480 0.803 rs160649 chr7:65543199 C/T cg12463550 chr7:65579703 CRCP 0.65 5.11 0.3 6.05e-7 Diabetic kidney disease; CESC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg05368731 chr17:41323189 NBR1 0.8 10.98 0.56 2.35e-23 Menopause (age at onset); CESC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg03351412 chr1:154909251 PMVK 0.65 8.6 0.47 7.02e-16 Prostate cancer; CESC cis rs6831352 0.589 rs2602836 chr4:100014805 C/T cg13256891 chr4:100009986 ADH5 -0.77 -10.5 -0.54 8.63e-22 Alcohol dependence; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03539850 chr10:91404063 PANK1 -0.51 -6.51 -0.37 3.78e-10 Asthma; CESC cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg00409905 chr10:38381863 ZNF37A -0.45 -6.0 -0.35 6.61e-9 Extrinsic epigenetic age acceleration; CESC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.9 0.52 7.05e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg17376030 chr22:41985996 PMM1 0.75 8.13 0.45 1.65e-14 Vitiligo; CESC cis rs561341 0.710 rs9900031 chr17:30199537 T/C cg13647721 chr17:30228624 UTP6 -0.62 -5.84 -0.34 1.52e-8 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10384294 chr12:57636980 NA -0.56 -6.78 -0.38 7.98e-11 Gut microbiome composition (summer); CESC cis rs2749592 0.550 rs4934881 chr10:37914346 A/C cg00409905 chr10:38381863 ZNF37A 0.42 5.55 0.32 7.09e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg04267008 chr7:1944627 MAD1L1 -0.7 -8.86 -0.48 1.16e-16 Bipolar disorder and schizophrenia; CESC cis rs763121 0.925 rs1056661 chr22:39080245 A/G cg06544989 chr22:39130855 UNC84B 0.48 9.06 0.49 3.03e-17 Menopause (age at onset); CESC cis rs7772486 0.686 rs9403739 chr6:146015357 A/G cg23711669 chr6:146136114 FBXO30 -0.92 -12.9 -0.62 6.98e-30 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26907429 chr1:165667743 ALDH9A1 0.62 6.61 0.38 2.13e-10 Gut microbiome composition (summer); CESC cis rs9309473 0.519 rs13009035 chr2:73845709 T/C cg20560298 chr2:73613845 ALMS1 0.46 6.47 0.37 4.83e-10 Metabolite levels; CESC cis rs2439831 0.850 rs9944216 chr15:44160773 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.69 -7.38 -0.41 2.02e-12 Lung cancer in ever smokers; CESC cis rs116095464 0.558 rs2288459 chr5:231143 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.5 -0.46 1.44e-15 Breast cancer; CESC cis rs2249694 0.878 rs2480257 chr10:135352509 T/A cg20169779 chr10:135381914 SYCE1 0.41 5.76 0.33 2.33e-8 Obesity-related traits; CESC cis rs938554 0.784 rs13145758 chr4:9981997 G/A cg00071950 chr4:10020882 SLC2A9 0.47 5.64 0.33 4.35e-8 Blood metabolite levels; CESC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.68 0.61 4e-29 Gut microbiome composition (summer); CESC cis rs7789940 0.951 rs7787526 chr7:75947553 C/T cg10167463 chr7:75959203 YWHAG -0.51 -6.01 -0.35 6.11e-9 Multiple sclerosis; CESC cis rs2213920 0.516 rs35976675 chr9:118173444 T/C cg13918206 chr9:118159781 DEC1 -0.66 -5.41 -0.32 1.43e-7 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CESC trans rs66573146 0.656 rs66905212 chr4:6949508 G/C cg07817883 chr1:32538562 TMEM39B 1.35 8.85 0.48 1.24e-16 Granulocyte percentage of myeloid white cells; CESC trans rs1814175 0.817 rs28525029 chr11:50045815 A/G cg03929089 chr4:120376271 NA -0.94 -16.17 -0.7 2.25e-41 Height; CESC cis rs66561647 0.719 rs7821928 chr8:128939295 G/A cg05480350 chr8:128972681 MIR1205;PVT1 0.45 5.87 0.34 1.28e-8 Hemoglobin concentration; CESC cis rs4803468 1.000 rs4803469 chr19:41922775 A/C cg09537434 chr19:41945824 ATP5SL -1.11 -20.39 -0.78 3.11e-56 Height; CESC cis rs2109514 0.765 rs768108 chr7:116108658 A/G cg12739419 chr7:116140593 CAV2 -0.3 -5.52 -0.32 7.94e-8 Prevalent atrial fibrillation; CESC cis rs76419734 0.510 rs2193856 chr4:106742958 A/C cg24545054 chr4:106630052 GSTCD;INTS12 -0.63 -6.36 -0.36 8.64e-10 Post bronchodilator FEV1; CESC cis rs1691799 0.867 rs1168343 chr12:66758581 C/T cg16791601 chr12:66731901 HELB -0.79 -14.12 -0.66 3.81e-34 White blood cell count (basophil); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25886382 chr13:26760664 NA -0.39 -6.15 -0.35 2.76e-9 Gambling; CESC cis rs4141404 0.737 rs5998058 chr22:32006408 C/T cg02404636 chr22:31891804 SFI1 0.45 6.09 0.35 4.05e-9 Paclitaxel-induced neuropathy; CESC cis rs8114671 0.836 rs6142294 chr20:33671497 A/G cg24642439 chr20:33292090 TP53INP2 -0.49 -5.91 -0.34 1.04e-8 Height; CESC cis rs1865721 0.755 rs3813081 chr18:73185096 A/G cg26385618 chr18:73139727 C18orf62 -0.42 -6.3 -0.36 1.24e-9 Intelligence; CESC cis rs868036 1.000 rs884202 chr15:68054388 G/A cg08079166 chr15:68083412 MAP2K5 -0.42 -6.51 -0.37 3.67e-10 Restless legs syndrome; CESC cis rs832540 0.902 rs194059 chr5:56197416 G/A cg14703610 chr5:56206110 C5orf35 0.54 7.22 0.41 5.64e-12 Coronary artery disease; CESC cis rs12477438 0.765 rs6737257 chr2:99683330 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs4835473 0.868 rs35016507 chr4:144655770 G/A cg25736465 chr4:144833511 NA -0.33 -5.23 -0.31 3.44e-7 Immature fraction of reticulocytes; CESC cis rs2299587 0.554 rs13253029 chr8:17749622 C/T cg08627089 chr8:17753878 FGL1 -0.39 -5.57 -0.32 6.34e-8 Economic and political preferences; CESC cis rs6912958 1.000 rs13214153 chr6:88153983 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -7.58 -0.42 5.88e-13 Monocyte percentage of white cells; CESC cis rs34779708 0.733 rs16935948 chr10:35549748 C/G cg03585969 chr10:35415529 CREM 0.62 6.79 0.39 7.28e-11 Inflammatory bowel disease;Crohn's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03443922 chr7:107384711 CBLL1 0.49 6.45 0.37 5.27e-10 Gut microbiota (bacterial taxa); CESC cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg10057126 chr4:77819792 ANKRD56 0.58 8.5 0.46 1.43e-15 Emphysema distribution in smoking; CESC cis rs1538970 0.962 rs4660301 chr1:45820149 T/A cg05343316 chr1:45956843 TESK2 0.82 11.17 0.57 5.6e-24 Platelet count; CESC cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg24130564 chr14:104152367 KLC1 -0.5 -6.8 -0.39 6.77e-11 Reticulocyte count; CESC cis rs8044868 0.521 rs7203821 chr16:72101165 T/C cg23815491 chr16:72088622 HP 0.34 5.16 0.3 4.87e-7 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7520050 0.966 rs12049588 chr1:46472422 G/A cg24296786 chr1:45957014 TESK2 0.44 5.5 0.32 9.17e-8 Red blood cell count;Reticulocyte count; CESC trans rs9650657 0.571 rs4240673 chr8:10787612 T/C cg15556689 chr8:8085844 FLJ10661 -0.55 -6.84 -0.39 5.5e-11 Neuroticism; CESC cis rs2204008 0.714 rs11520135 chr12:38114863 C/T cg13010199 chr12:38710504 ALG10B 0.54 6.71 0.38 1.17e-10 Bladder cancer; CESC cis rs1008375 0.966 rs3796812 chr4:17582051 G/A cg02297831 chr4:17616191 MED28 0.44 5.43 0.32 1.29e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.79 8.79 0.47 1.98e-16 Alzheimer's disease; CESC trans rs10751667 0.961 rs7396670 chr11:929269 A/G cg00159523 chr10:114713187 TCF7L2 -0.41 -6.11 -0.35 3.52e-9 Alzheimer's disease (late onset); CESC trans rs9929218 0.953 rs3114411 chr16:68734591 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.77 10.24 0.53 5.92e-21 Colorectal cancer; CESC cis rs1348850 0.554 rs11679519 chr2:178432110 C/T cg22681709 chr2:178499509 PDE11A -0.53 -6.59 -0.38 2.3e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg21285383 chr16:89894308 SPIRE2 0.31 5.45 0.32 1.15e-7 Vitiligo; CESC cis rs1595825 1.000 rs7579905 chr2:198868109 T/A cg00982548 chr2:198649783 BOLL -0.44 -5.05 -0.3 8.32e-7 Ulcerative colitis; CESC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg09658497 chr7:2847517 GNA12 -0.43 -6.15 -0.35 2.86e-9 Height; CESC cis rs965469 0.779 rs6037515 chr20:3233091 C/A cg25506879 chr20:3388711 C20orf194 -0.51 -5.57 -0.32 6.1e-8 IFN-related cytopenia; CESC cis rs10411936 1.000 rs16995422 chr19:16519045 A/G cg10248733 chr19:16607483 C19orf44;CALR3 -0.5 -6.08 -0.35 4.18e-9 White blood cell count;Multiple sclerosis; CESC cis rs1018836 0.632 rs7002775 chr8:91476765 C/T cg16814680 chr8:91681699 NA 0.63 8.82 0.48 1.58e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4660306 0.961 rs4660864 chr1:45966582 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.62 -7.82 -0.43 1.23e-13 Homocysteine levels; CESC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg03452623 chr4:187889614 NA -0.87 -14.96 -0.68 4.25e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs8023845 0.954 rs1680156 chr15:40447265 T/C cg20259534 chr15:40453036 BUB1B 0.7 7.22 0.41 5.52e-12 Chronic lymphocytic leukemia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20592656 chr7:5417060 TNRC18 0.46 6.2 0.36 2.14e-9 Fibrinogen levels; CESC cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg17366294 chr4:99064904 C4orf37 0.59 8.39 0.46 2.85e-15 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05221349 chr4:100870488 LOC256880;H2AFZ -0.4 -6.74 -0.38 1e-10 Gambling; CESC trans rs360798 0.532 rs9636442 chr2:62806286 A/G cg07814414 chr15:31774773 NA -0.43 -6.26 -0.36 1.55e-9 Coronary artery disease; CESC cis rs2243480 1.000 rs410128 chr7:65603173 C/T cg12463550 chr7:65579703 CRCP 0.74 5.66 0.33 3.91e-8 Diabetic kidney disease; CESC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg15595755 chr5:1867978 NA 0.53 8.91 0.48 8.18e-17 Cardiovascular disease risk factors; CESC cis rs1707322 0.927 rs11211194 chr1:46282084 C/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2598107 0.542 rs6965395 chr7:37950115 C/T cg10806140 chr7:37956554 SFRP4 0.32 5.13 0.3 5.54e-7 Dupuytren's disease; CESC cis rs8060686 0.641 rs1125333 chr16:68227566 C/A cg26727032 chr16:67993705 SLC12A4 -0.53 -5.95 -0.34 8.44e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18664336 chr17:57970265 TUBD1;RPS6KB1 -0.57 -6.65 -0.38 1.7e-10 Gut microbiome composition (summer); CESC cis rs9902453 0.780 rs7210991 chr17:28190961 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.21 0.45 9.9e-15 Coffee consumption (cups per day); CESC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg11764359 chr7:65958608 NA 0.79 11.32 0.57 1.67e-24 Aortic root size; CESC cis rs3892630 0.757 rs8109823 chr19:33183316 A/G cg13157960 chr19:33183277 NUDT19 0.53 5.2 0.3 4.04e-7 Red blood cell traits; CESC cis rs6500395 0.963 rs2041921 chr16:48714002 T/C cg04672837 chr16:48644449 N4BP1 -0.49 -6.05 -0.35 4.8e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs12765878 1.000 rs12765878 chr10:105669622 C/T cg24587175 chr10:105670608 OBFC1 -0.34 -5.56 -0.32 6.67e-8 Coronary artery disease; CESC cis rs6429082 0.818 rs704714 chr1:235632094 T/C cg26050004 chr1:235667680 B3GALNT2 0.62 7.88 0.44 8.78e-14 Adiposity; CESC cis rs3820928 0.874 rs4675137 chr2:227883910 G/C cg11843606 chr2:227700838 RHBDD1 -0.46 -6.09 -0.35 3.87e-9 Pulmonary function; CESC cis rs6500395 0.928 rs4785532 chr16:48695500 G/A cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7091068 0.550 rs7901909 chr10:95492508 C/T cg20715218 chr10:95462985 C10orf4 0.51 6.42 0.37 6.42e-10 Urinary tract infection frequency; CESC cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg20891283 chr12:69753455 YEATS4 0.91 15.05 0.68 2.02e-37 Blood protein levels; CESC cis rs6089584 0.627 rs35560719 chr20:60561917 A/C cg24733560 chr20:60626293 TAF4 0.42 6.29 0.36 1.33e-9 Body mass index; CESC cis rs7659604 0.502 rs11098640 chr4:122675875 G/A cg19671926 chr4:122722719 EXOSC9 0.53 6.7 0.38 1.21e-10 Type 2 diabetes; CESC trans rs877282 0.842 rs35872126 chr10:764545 G/A cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg11890956 chr21:40555474 PSMG1 -0.66 -9.11 -0.49 2.05e-17 Menarche (age at onset); CESC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg12463550 chr7:65579703 CRCP -0.53 -6.91 -0.39 3.65e-11 Aortic root size; CESC cis rs916888 0.821 rs199514 chr17:44856881 G/A cg01570182 chr17:44337453 NA -0.87 -10.25 -0.53 5.7e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs7246760 0.867 rs55800282 chr19:9833530 A/G cg02900749 chr2:68251473 NA -0.85 -7.44 -0.42 1.38e-12 Pursuit maintenance gain; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27600497 chr7:155091023 INSIG1 0.46 6.23 0.36 1.85e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8020095 0.528 rs1044745 chr14:67800815 G/A cg19548862 chr14:67692701 FAM71D -0.45 -5.3 -0.31 2.41e-7 Depression (quantitative trait); CESC cis rs7219021 0.926 rs7217983 chr17:46853345 A/G cg16584676 chr17:46985605 UBE2Z -0.52 -5.9 -0.34 1.12e-8 Schizophrenia or bipolar disorder; CESC cis rs4237845 0.788 rs1962047 chr12:58292707 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.49 5.43 0.32 1.26e-7 Intelligence (multi-trait analysis); CESC cis rs9486719 0.749 rs1009596 chr6:96843688 A/G cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg25767906 chr1:53392781 SCP2 0.43 5.85 0.34 1.42e-8 Monocyte count; CESC cis rs36051895 0.664 rs10117565 chr9:5094461 G/A cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.61e-9 Pediatric autoimmune diseases; CESC cis rs6060717 0.553 rs2590958 chr20:34616590 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -7.83 -0.43 1.17e-13 Hip circumference adjusted for BMI; CESC trans rs2900976 0.739 rs13033187 chr2:71993619 C/A cg01646268 chr11:14367071 RRAS2 0.49 6.24 0.36 1.76e-9 Protein quantitative trait loci; CESC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.5e-8 Developmental language disorder (linguistic errors); CESC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg21226059 chr5:178986404 RUFY1 0.51 7.6 0.42 5.26e-13 Lung cancer; CESC cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg12756686 chr19:29218302 NA 0.54 6.5 0.37 3.99e-10 Methadone dose in opioid dependence; CESC cis rs672059 0.513 rs572977 chr1:183164991 C/G cg23696949 chr1:183155644 LAMC2 -0.25 -5.82 -0.34 1.69e-8 Hypertriglyceridemia; CESC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg18350739 chr11:68623251 NA -0.46 -7.02 -0.4 1.87e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.55 7.42 0.41 1.57e-12 Lymphocyte counts; CESC cis rs2688608 0.592 rs3933085 chr10:75483331 C/T cg23231163 chr10:75533350 FUT11 -0.36 -5.42 -0.32 1.33e-7 Inflammatory bowel disease; CESC cis rs920590 0.684 rs7461774 chr8:19666645 G/A cg17834443 chr8:19674713 INTS10 0.59 6.47 0.37 4.76e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.72 0.62 2.99e-29 Alzheimer's disease; CESC cis rs826838 1.000 rs11168367 chr12:38913397 T/G cg13010199 chr12:38710504 ALG10B 0.6 8.42 0.46 2.34e-15 Heart rate; CESC cis rs3733585 0.781 rs4292328 chr4:9970962 C/T cg02734326 chr4:10020555 SLC2A9 -0.45 -6.74 -0.38 1e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13108904 0.870 rs4974545 chr4:1271923 C/T cg00684032 chr4:1343700 KIAA1530 0.41 5.87 0.34 1.33e-8 Obesity-related traits; CESC cis rs10927875 0.557 rs1572381 chr1:16344494 G/A cg22431228 chr1:16359049 CLCNKA -0.53 -10.31 -0.54 3.47e-21 Dilated cardiomyopathy; CESC cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg22875332 chr1:76189707 ACADM 0.62 6.32 0.36 1.13e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9486719 0.948 rs2472906 chr6:96875318 G/T cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs10905065 0.931 rs10795510 chr10:5758827 G/A cg11519256 chr10:5708881 ASB13 0.44 5.9 0.34 1.11e-8 Menopause (age at onset); CESC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.72 -0.33 2.89e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs12681288 0.550 rs4637864 chr8:959761 C/T cg15309053 chr8:964076 NA 0.48 8.23 0.45 8.5e-15 Schizophrenia; CESC cis rs4950928 0.887 rs7556099 chr1:203166198 C/G cg17014757 chr1:203156097 CHI3L1 -0.51 -5.11 -0.3 6.1e-7 YKL-40 levels; CESC cis rs1355223 0.872 rs12802798 chr11:34747434 T/G cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.12 -0.35 3.26e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs897984 0.806 rs12924903 chr16:30928970 C/T cg00531865 chr16:30841666 NA -0.49 -6.58 -0.37 2.57e-10 Dementia with Lewy bodies; CESC cis rs4253772 0.938 rs75977757 chr22:46641525 G/T cg00784671 chr22:46762841 CELSR1 -0.57 -5.62 -0.33 4.95e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7223966 1.000 rs8078462 chr17:61857937 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.73 0.38 1.06e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4836694 0.574 rs4837476 chr9:132937533 T/C cg13414629 chr9:132935646 FREQ 0.42 5.29 0.31 2.5e-7 Alzheimer's disease (cognitive decline); CESC cis rs4950928 0.823 rs4950882 chr1:203164848 A/G cg17014757 chr1:203156097 CHI3L1 -0.53 -5.23 -0.31 3.39e-7 YKL-40 levels; CESC cis rs9486719 1.000 rs12208011 chr6:96991105 G/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.83 -0.34 1.64e-8 Migraine;Coronary artery disease; CESC cis rs2658782 0.951 rs2608214 chr11:93148665 C/T cg15737290 chr11:93063684 CCDC67 0.55 6.92 0.39 3.49e-11 Pulmonary function decline; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08131204 chr22:41487073 MIR1281 -0.52 -7.01 -0.4 2.01e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs300703 0.872 rs12233077 chr2:120949 T/A cg21211680 chr2:198530 NA -0.86 -6.93 -0.39 3.16e-11 Blood protein levels; CESC cis rs735860 0.674 rs209485 chr6:53174448 C/T cg10236188 chr6:53219634 NA -0.37 -5.52 -0.32 7.98e-8 Glaucoma; CESC cis rs9858542 0.953 rs35169793 chr3:49423274 A/G cg07274523 chr3:49395745 GPX1 0.68 8.44 0.46 2.17e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs3741798 1.000 rs17375328 chr12:12485292 T/C cg08615371 chr12:12503544 MANSC1 0.9 6.53 0.37 3.39e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7208859 0.623 rs11652358 chr17:29205480 T/C cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg22143856 chr6:28129313 ZNF389 0.44 5.84 0.34 1.49e-8 Depression; CESC cis rs2658782 0.756 rs3019222 chr11:93079718 C/T cg15737290 chr11:93063684 CCDC67 0.58 7.38 0.41 2e-12 Pulmonary function decline; CESC cis rs7647973 0.626 rs1996663 chr3:49878264 C/G cg06212747 chr3:49208901 KLHDC8B -0.6 -7.36 -0.41 2.25e-12 Menarche (age at onset); CESC cis rs9814567 0.762 rs13067564 chr3:134209956 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.44 5.69 0.33 3.35e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs854765 0.583 rs11650649 chr17:17790319 C/A cg09796270 chr17:17721594 SREBF1 -0.45 -6.32 -0.36 1.12e-9 Total body bone mineral density; CESC cis rs9303401 0.659 rs17222523 chr17:56620501 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.92 0.62 6.16e-30 Cognitive test performance; CESC cis rs3126085 0.935 rs11204943 chr1:152203906 A/C cg03465714 chr1:152285911 FLG -0.43 -5.17 -0.3 4.7e-7 Atopic dermatitis; CESC cis rs6061231 0.505 rs13037253 chr20:60928724 G/A cg22541963 chr20:60982533 CABLES2 0.48 5.09 0.3 6.64e-7 Colorectal cancer; CESC cis rs11098499 0.874 rs12509054 chr4:120115075 A/C cg09307838 chr4:120376055 NA 0.74 9.24 0.49 8.6e-18 Corneal astigmatism; CESC cis rs2439831 1.000 rs2601014 chr15:43756013 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.9 9.31 0.5 5e-18 Lung cancer in ever smokers; CESC cis rs9815354 1.000 rs11928580 chr3:41885722 C/T cg03022575 chr3:42003672 ULK4 0.45 5.29 0.31 2.59e-7 Pulse pressure;Diastolic blood pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19937698 chr13:60970319 TDRD3 -0.42 -6.13 -0.35 3.22e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27046659 chr10:75634352 CAMK2G 0.61 6.78 0.38 7.66e-11 Gut microbiome composition (summer); CESC cis rs2842992 0.714 rs2495278 chr6:160123674 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.74 8.97 0.48 5.37e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg21280719 chr6:42927975 GNMT -0.3 -7.32 -0.41 3.05e-12 Alzheimer's disease in APOE e4+ carriers; CESC cis rs662064 0.962 rs6540933 chr1:10547263 C/T cg20482658 chr1:10539492 PEX14 -0.4 -8.1 -0.45 2.02e-14 Asthma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07732421 chr5:74633253 HMGCR -0.41 -6.14 -0.35 3e-9 Gambling; CESC cis rs35110281 0.591 rs162366 chr21:44935383 C/T cg01579765 chr21:45077557 HSF2BP 0.48 8.13 0.45 1.63e-14 Mean corpuscular volume; CESC cis rs2228479 0.702 rs17233868 chr16:89803629 C/T cg06558623 chr16:89946397 TCF25 1.06 8.28 0.45 6.12e-15 Skin colour saturation; CESC cis rs2832191 0.716 rs2297252 chr21:30377104 G/A cg08807101 chr21:30365312 RNF160 0.96 15.02 0.68 2.66e-37 Dental caries; CESC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg07211511 chr3:129823064 LOC729375 -0.59 -7.28 -0.41 3.84e-12 Blood pressure (smoking interaction); CESC trans rs3942852 0.869 rs4752806 chr11:48118199 G/C cg15704280 chr7:45808275 SEPT13 -0.59 -6.83 -0.39 5.9e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs1153858 1.000 rs12591058 chr15:45640172 T/C cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs12142240 0.698 rs68191463 chr1:46808695 T/C cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs12477438 0.798 rs13393860 chr2:99590397 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.51 -0.54 7.92e-22 Chronic sinus infection; CESC cis rs2425143 0.818 rs12481545 chr20:34407698 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.4 0.31 1.49e-7 Blood protein levels; CESC cis rs941873 0.869 rs7917610 chr10:81117237 T/C cg11057378 chr10:81107060 PPIF 0.36 5.84 0.34 1.55e-8 Height; CESC cis rs36051895 0.623 rs12349113 chr9:5254224 T/A cg02405213 chr9:5042618 JAK2 -0.51 -6.3 -0.36 1.24e-9 Pediatric autoimmune diseases; CESC cis rs75804782 0.521 rs72993056 chr2:239404671 G/T cg18131467 chr2:239335373 ASB1 -0.71 -5.56 -0.32 6.45e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs10197940 0.571 rs13393021 chr2:152413258 A/C cg19508488 chr2:152266495 RIF1 0.51 5.99 0.35 6.85e-9 Lung cancer; CESC cis rs2281558 1.000 rs2281558 chr20:25240189 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.57 7.3 0.41 3.41e-12 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06905970 chr19:41222748 ADCK4;ITPKC -0.46 -6.75 -0.38 9.55e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19240110 chr19:17445963 ANO8 -0.46 -6.06 -0.35 4.65e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg04776990 chr17:42853002 ADAM11 0.61 6.1 0.35 3.66e-9 Diastolic blood pressure; CESC cis rs4568518 0.742 rs13245422 chr7:18015975 A/G cg03009463 chr7:17980271 SNX13 0.45 5.97 0.34 7.52e-9 Measles; CESC cis rs7834588 0.503 rs1378520 chr8:63840209 C/T cg20602954 chr8:63776762 NKAIN3 0.32 5.3 0.31 2.44e-7 Response to Vitamin E supplementation; CESC cis rs910316 0.763 rs175450 chr14:75590340 G/A cg16144293 chr14:75469539 EIF2B2 0.41 5.42 0.32 1.36e-7 Height; CESC cis rs2732480 0.577 rs1489109 chr12:48738780 C/A cg24011408 chr12:48396354 COL2A1 0.44 5.99 0.35 6.63e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs60843830 1.000 rs60149603 chr2:285421 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.69 8.62 0.47 6.18e-16 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg19770292 chr5:1868693 NA 0.3 5.04 0.3 8.57e-7 Cardiovascular disease risk factors; CESC cis rs10129255 0.500 rs8006888 chr14:107190456 A/C cg23076370 chr14:107095027 NA -0.65 -9.66 -0.51 4.15e-19 Kawasaki disease; CESC cis rs1551570 0.755 rs11667630 chr19:10229297 A/C cg16327482 chr19:10226339 EIF3G -0.5 -8.11 -0.45 1.93e-14 Narcolepsy; CESC cis rs4423214 0.802 rs4616066 chr11:71183846 G/A cg05163923 chr11:71159392 DHCR7 -0.68 -7.76 -0.43 1.82e-13 Vitamin D levels; CESC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg23161317 chr6:28129485 ZNF389 0.5 6.24 0.36 1.71e-9 Parkinson's disease; CESC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg19163074 chr7:65112434 INTS4L2 0.47 5.14 0.3 5.23e-7 Aortic root size; CESC cis rs727505 1.000 rs720614 chr7:124452790 T/C cg23710748 chr7:124431027 NA -0.46 -7.21 -0.41 5.71e-12 Lewy body disease; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01025762 chr7:107531363 DLD -0.46 -6.25 -0.36 1.6e-9 Height; CESC cis rs7385804 0.796 rs221799 chr7:100288545 G/A cg20848291 chr7:100343083 ZAN 0.55 7.54 0.42 7.56e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs2439831 0.850 rs3097773 chr15:43893072 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.75 -8.2 -0.45 1.01e-14 Lung cancer in ever smokers; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25951811 chr14:96858416 AK7 -0.48 -6.02 -0.35 5.77e-9 Ulcerative colitis; CESC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg22823121 chr1:150693482 HORMAD1 -0.46 -6.81 -0.39 6.43e-11 Tonsillectomy; CESC cis rs9815354 1.000 rs28702390 chr3:41889920 C/A cg03022575 chr3:42003672 ULK4 0.58 5.94 0.34 9.04e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs1506636 0.646 rs805779 chr7:123214835 C/T cg03229431 chr7:123269106 ASB15 -0.39 -5.24 -0.31 3.21e-7 Plateletcrit;Platelet count; CESC cis rs2806561 0.514 rs11801120 chr1:23543307 C/T cg19743168 chr1:23544995 NA 0.38 5.76 0.33 2.37e-8 Height; CESC cis rs4835473 0.897 rs6537170 chr4:144612900 A/T cg25736465 chr4:144833511 NA 0.35 5.16 0.3 4.8e-7 Immature fraction of reticulocytes; CESC cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.49 0.46 1.51e-15 Hip circumference adjusted for BMI; CESC cis rs67257959 1.000 rs67257959 chr19:17158145 T/C cg16202187 chr19:17186497 HAUS8;MYO9B 0.44 5.34 0.31 1.95e-7 Selective IgA deficiency; CESC cis rs854765 0.618 rs8068820 chr17:17834119 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.29 0.41 3.65e-12 Total body bone mineral density; CESC cis rs72781680 0.898 rs72782126 chr2:24039901 A/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs34779708 0.966 rs12773647 chr10:35440327 A/G cg03585969 chr10:35415529 CREM 0.73 9.58 0.51 7.16e-19 Inflammatory bowel disease;Crohn's disease; CESC trans rs61931739 0.500 rs7296061 chr12:34435009 A/G cg13010199 chr12:38710504 ALG10B -0.49 -6.39 -0.37 7.55e-10 Morning vs. evening chronotype; CESC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg21248554 chr2:27665150 KRTCAP3 -0.33 -6.73 -0.38 1.02e-10 Total body bone mineral density; CESC cis rs748404 0.697 rs574065 chr15:43550655 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.53 -8.06 -0.44 2.59e-14 Lung cancer; CESC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC trans rs61931739 0.929 rs10844740 chr12:34067930 C/T cg26384229 chr12:38710491 ALG10B -0.47 -6.66 -0.38 1.59e-10 Morning vs. evening chronotype; CESC cis rs2742234 0.590 rs1254960 chr10:43699657 C/T cg15436174 chr10:43711423 RASGEF1A 0.5 5.85 0.34 1.45e-8 Hirschsprung disease; CESC cis rs9905704 0.633 rs2680707 chr17:56455641 T/C cg12560992 chr17:57184187 TRIM37 -0.6 -5.8 -0.34 1.93e-8 Testicular germ cell tumor; CESC cis rs1506636 0.924 rs2402668 chr7:123296605 T/A cg03229431 chr7:123269106 ASB15 -0.53 -6.83 -0.39 5.87e-11 Plateletcrit;Platelet count; CESC cis rs1050631 0.592 rs1539823 chr18:33736261 T/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.53 7.16 0.4 7.87e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs2072732 0.861 rs67025412 chr1:2951806 T/C cg03976712 chr1:2946727 NA 0.33 5.45 0.32 1.17e-7 Plateletcrit; CESC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.96 10.67 0.55 2.46e-22 Mean platelet volume; CESC cis rs7662987 0.517 rs1154405 chr4:100008750 G/A cg13256891 chr4:100009986 ADH5 0.74 8.01 0.44 3.58e-14 Smoking initiation; CESC cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg05347473 chr6:146136440 FBXO30 0.58 7.41 0.41 1.68e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9399135 0.967 rs1590975 chr6:135352088 C/T cg24558204 chr6:135376177 HBS1L 0.48 6.64 0.38 1.73e-10 Red blood cell count; CESC cis rs6499255 1.000 rs11644838 chr16:69812705 G/C cg15192750 chr16:69999425 NA 0.46 5.64 0.33 4.46e-8 IgE levels; CESC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 11.12 0.56 8.06e-24 Platelet count; CESC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg14926445 chr8:58193284 C8orf71 -0.54 -5.24 -0.31 3.28e-7 Developmental language disorder (linguistic errors); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04230901 chr1:235292294 SNORA14B;TOMM20 -0.55 -6.54 -0.37 3.07e-10 Ulcerative colitis; CESC cis rs2380220 0.516 rs7748108 chr6:96008082 T/C cg04719120 chr6:96025338 MANEA 0.52 5.9 0.34 1.12e-8 Behavioural disinhibition (generation interaction); CESC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.24 -0.31 3.23e-7 Lung cancer; CESC cis rs2072499 0.767 rs3001789 chr1:156197614 T/G cg25208724 chr1:156163844 SLC25A44 0.84 13.29 0.63 3.21e-31 Testicular germ cell tumor; CESC cis rs12142240 0.698 rs17357711 chr1:46829013 A/G cg10495392 chr1:46806563 NSUN4 0.58 6.3 0.36 1.24e-9 Menopause (age at onset); CESC trans rs3942852 0.806 rs10838805 chr11:48118993 A/C cg15704280 chr7:45808275 SEPT13 -0.61 -7.18 -0.4 7.06e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.8 0.65 5.22e-33 Prudent dietary pattern; CESC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.7 -7.96 -0.44 5.16e-14 Alzheimer's disease; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg24583131 chr6:18265189 DEK 0.47 6.05 0.35 4.8e-9 Obesity-related traits; CESC cis rs763121 0.819 rs5750658 chr22:39060917 C/T cg06022373 chr22:39101656 GTPBP1 0.88 13.88 0.65 2.66e-33 Menopause (age at onset); CESC cis rs9581857 1.000 rs9581857 chr13:28027714 A/C cg22138327 chr13:27999177 GTF3A 0.64 5.14 0.3 5.37e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs72781680 0.898 rs72796396 chr2:24178154 G/A cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs9929218 0.817 rs8055912 chr16:68802068 C/T cg02972257 chr16:68554789 NA 0.44 5.27 0.31 2.78e-7 Colorectal cancer; CESC cis rs754466 0.580 rs1344966 chr10:79534527 T/C cg17075019 chr10:79541650 NA -0.87 -13.7 -0.64 1.14e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg18230493 chr5:56204884 C5orf35 -0.75 -8.9 -0.48 9.02e-17 Initial pursuit acceleration; CESC cis rs2239815 0.576 rs10427628 chr22:29239766 T/C cg15103426 chr22:29168792 CCDC117 0.52 5.84 0.34 1.52e-8 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; CESC cis rs116095464 0.558 rs10065584 chr5:253997 G/A cg22496380 chr5:211416 CCDC127 -0.98 -9.98 -0.52 4.08e-20 Breast cancer; CESC cis rs7267979 1.000 rs2259956 chr20:25282433 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs72829446 0.530 rs8075007 chr17:7374507 A/T cg02795151 chr17:7402630 POLR2A 0.58 5.99 0.35 6.89e-9 Androgen levels; CESC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs155076 1.000 rs12870992 chr13:21846019 A/G cg11317459 chr13:21872234 NA 0.91 8.96 0.48 5.78e-17 White matter hyperintensity burden; CESC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg24675658 chr1:53192096 ZYG11B 0.54 7.53 0.42 7.86e-13 Monocyte count; CESC trans rs11764590 0.694 rs6461115 chr7:2103668 A/G cg11693508 chr17:37793320 STARD3 0.54 6.37 0.36 8.23e-10 Neuroticism; CESC cis rs9549367 0.569 rs3024719 chr13:113814225 G/A cg18105134 chr13:113819100 PROZ -0.8 -9.13 -0.49 1.84e-17 Platelet distribution width; CESC cis rs477692 0.563 rs7079165 chr10:131430240 G/A cg24747557 chr10:131355152 MGMT 0.38 5.45 0.32 1.13e-7 Response to temozolomide; CESC cis rs2625529 0.730 rs3759900 chr15:72451827 A/C cg16672083 chr15:72433130 SENP8 0.47 7.0 0.4 2.06e-11 Red blood cell count; CESC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg09658497 chr7:2847517 GNA12 -0.35 -5.09 -0.3 6.67e-7 Height; CESC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg17971929 chr21:40555470 PSMG1 -0.88 -12.82 -0.62 1.38e-29 Cognitive function; CESC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.58 0.37 2.57e-10 Prudent dietary pattern; CESC cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg12193833 chr17:30244370 NA -0.71 -6.53 -0.37 3.38e-10 Hip circumference adjusted for BMI; CESC cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg12365402 chr11:9010492 NRIP3 -0.32 -5.07 -0.3 7.37e-7 Hemoglobin concentration; CESC cis rs7084402 0.967 rs10826198 chr10:60274182 C/T cg07615347 chr10:60278583 BICC1 -0.57 -8.96 -0.48 6.01e-17 Refractive error; CESC cis rs17125944 0.686 rs78623109 chr14:53383077 G/T cg00686598 chr14:53173677 PSMC6 0.96 6.93 0.39 3.2e-11 Alzheimer's disease (late onset); CESC cis rs9902453 0.791 rs57719820 chr17:28335088 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.83 -0.43 1.15e-13 Coffee consumption (cups per day); CESC cis rs4332037 0.530 rs62434669 chr7:1866946 G/A cg23422044 chr7:1970798 MAD1L1 -0.51 -5.13 -0.3 5.48e-7 Bipolar disorder; CESC cis rs473651 0.935 rs482775 chr2:239335403 G/C cg18131467 chr2:239335373 ASB1 1.02 21.0 0.79 2.57e-58 Multiple system atrophy; CESC cis rs1568889 1.000 rs61236373 chr11:28212720 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.58 0.54 4.76e-22 Bipolar disorder; CESC cis rs6545883 0.929 rs2256615 chr2:61679894 C/G cg15711740 chr2:61764176 XPO1 -0.4 -5.22 -0.31 3.61e-7 Tuberculosis; CESC cis rs477692 0.669 rs12265939 chr10:131445398 A/G cg05714579 chr10:131428358 MGMT -0.59 -8.3 -0.45 5.33e-15 Response to temozolomide; CESC cis rs10504229 0.679 rs1442125 chr8:58036258 A/C cg24829409 chr8:58192753 C8orf71 0.45 5.75 0.33 2.49e-8 Developmental language disorder (linguistic errors); CESC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg07167872 chr1:205819463 PM20D1 -0.38 -5.31 -0.31 2.35e-7 Menarche (age at onset); CESC cis rs9549367 0.789 rs9549705 chr13:113888425 T/C cg18105134 chr13:113819100 PROZ -0.69 -8.37 -0.46 3.39e-15 Platelet distribution width; CESC cis rs2228479 0.850 rs11645916 chr16:89835234 G/A cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs28374715 0.662 rs28587487 chr15:41495460 C/T cg18705301 chr15:41695430 NDUFAF1 -0.83 -10.66 -0.55 2.62e-22 Ulcerative colitis; CESC cis rs7607369 0.680 rs533760 chr2:219381405 T/C cg02176678 chr2:219576539 TTLL4 0.5 9.03 0.48 3.72e-17 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs9894429 0.646 rs7405870 chr17:79617284 G/A cg13777783 chr17:79615861 NA -0.33 -5.51 -0.32 8.56e-8 Eye color traits; CESC cis rs12200560 0.505 rs211164 chr6:97068140 G/T cg06623918 chr6:96969491 KIAA0776 0.47 5.81 0.34 1.79e-8 Coronary heart disease; CESC cis rs4969178 0.965 rs8071884 chr17:76398058 C/G cg05887092 chr17:76393375 PGS1 0.59 9.21 0.49 1.06e-17 HDL cholesterol levels; CESC cis rs3845702 0.736 rs6433821 chr2:180837806 T/A cg01881094 chr2:180872142 CWC22 -1.08 -9.69 -0.51 3.43e-19 Schizophrenia; CESC trans rs9929218 1.000 rs9937664 chr16:68784603 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.72 -9.06 -0.49 2.89e-17 Colorectal cancer; CESC cis rs71277158 0.688 rs80038349 chr3:169844718 G/T cg04067573 chr3:169899625 PHC3 0.56 5.76 0.33 2.3e-8 Prostate cancer; CESC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg24060327 chr5:131705240 SLC22A5 -0.77 -10.91 -0.56 4e-23 Breast cancer; CESC cis rs4595586 0.545 rs12809206 chr12:39388748 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.6 0.42 4.97e-13 Morning vs. evening chronotype; CESC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg24562669 chr7:97807699 LMTK2 0.49 7.17 0.4 7.48e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs6088580 0.601 rs6120668 chr20:33099793 A/G cg06115741 chr20:33292138 TP53INP2 0.45 5.8 0.34 1.88e-8 Glomerular filtration rate (creatinine); CESC cis rs938554 0.910 rs10010582 chr4:9937085 C/T cg00071950 chr4:10020882 SLC2A9 -0.42 -5.18 -0.3 4.36e-7 Blood metabolite levels; CESC cis rs4891159 0.548 rs617823 chr18:74120233 A/G cg24786174 chr18:74118243 ZNF516 0.86 16.21 0.71 1.55e-41 Longevity; CESC cis rs2075671 0.903 rs4727459 chr7:100276821 T/C cg20848291 chr7:100343083 ZAN -0.8 -10.16 -0.53 1.09e-20 Other erythrocyte phenotypes; CESC cis rs9303401 0.659 rs11495824 chr17:56918882 C/A cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.69 0.61 3.78e-29 Cognitive test performance; CESC cis rs6460942 0.659 rs17192500 chr7:12545379 A/G cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC cis rs10788264 0.504 rs4751885 chr10:124020305 G/T cg09507567 chr10:124027408 NA 0.41 5.62 0.33 4.71e-8 Total body bone mineral density; CESC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg08859206 chr1:53392774 SCP2 0.54 7.13 0.4 9.54e-12 Monocyte count; CESC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.25 -0.36 1.67e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg17178900 chr1:205818956 PM20D1 0.8 12.65 0.61 5.1e-29 Menarche (age at onset); CESC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg16743903 chr16:89593216 SPG7 -0.45 -5.78 -0.33 2.1e-8 Multiple myeloma (IgH translocation); CESC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.77 -8.64 -0.47 5.4e-16 Gut microbiome composition (summer); CESC cis rs9486715 0.867 rs926277 chr6:96868837 T/A cg06623918 chr6:96969491 KIAA0776 0.91 14.05 0.65 6.83e-34 Headache; CESC cis rs61931739 0.500 rs6488221 chr12:34525671 A/G cg06521331 chr12:34319734 NA -0.37 -5.15 -0.3 5.19e-7 Morning vs. evening chronotype; CESC cis rs11683229 0.778 rs72811598 chr2:63326416 T/G cg17519650 chr2:63277830 OTX1 -0.68 -5.33 -0.31 2.12e-7 Protein quantitative trait loci; CESC trans rs863345 0.967 rs1342958 chr1:158468676 A/C cg18533943 chr14:65380954 CHURC1 -0.44 -6.25 -0.36 1.59e-9 Pneumococcal bacteremia; CESC cis rs4718428 0.705 rs4718424 chr7:66376095 G/A cg18252515 chr7:66147081 NA -0.45 -5.14 -0.3 5.32e-7 Corneal structure; CESC cis rs4718428 0.705 rs13231140 chr7:66361618 C/G cg12165864 chr7:66369176 NA -0.66 -7.66 -0.43 3.45e-13 Corneal structure; CESC cis rs7267979 0.586 rs1007708 chr20:25190959 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.66 10.85 0.55 6.27e-23 Liver enzyme levels (alkaline phosphatase); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18173830 chr6:4776623 CDYL -0.53 -7.7 -0.43 2.78e-13 Gambling; CESC cis rs72945132 0.882 rs7945389 chr11:70158876 C/A cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg11859384 chr17:80120422 CCDC57 0.38 5.22 0.31 3.67e-7 Life satisfaction; CESC cis rs738322 0.934 rs84473 chr22:38557326 T/C cg17652424 chr22:38574118 PLA2G6 -0.34 -6.19 -0.36 2.28e-9 Cutaneous nevi; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05904283 chr16:716021 WDR90 -0.55 -6.1 -0.35 3.66e-9 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs2815371 chr1:67504313 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.99 13.22 0.63 5.4e-31 Lymphocyte percentage of white cells; CESC cis rs1642645 0.831 rs3856259 chr1:42475503 T/C cg16685388 chr1:42384056 HIVEP3 0.38 5.68 0.33 3.57e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs2239547 0.657 rs2276817 chr3:52860936 C/T cg11645453 chr3:52864694 ITIH4 0.32 5.89 0.34 1.15e-8 Schizophrenia; CESC cis rs8017423 0.935 rs3783838 chr14:90733012 A/G cg14092571 chr14:90743983 NA 0.53 7.96 0.44 4.93e-14 Mortality in heart failure; CESC cis rs6963495 0.745 rs2392749 chr7:105182605 A/G cg02135003 chr7:105160482 PUS7 -0.43 -5.98 -0.35 7.05e-9 Bipolar disorder (body mass index interaction); CESC cis rs7927592 0.956 rs6591341 chr11:68335478 C/T cg16797656 chr11:68205561 LRP5 0.42 6.21 0.36 2e-9 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13499067 chr11:10879629 ZBED5 -0.49 -6.64 -0.38 1.78e-10 Fibrinogen levels; CESC cis rs6691722 0.503 rs2274167 chr1:24707296 C/T cg02336364 chr1:24764700 NIPAL3 0.32 6.58 0.37 2.48e-10 Response to interferon beta in multiple sclerosis; CESC cis rs6460942 0.915 rs17444044 chr7:12458736 A/G cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg08027265 chr7:2291960 NA -0.46 -7.15 -0.4 8.3e-12 Schizophrenia; CESC trans rs10411161 0.752 rs10404812 chr19:52400691 T/C cg22319618 chr22:45562946 NUP50 -0.76 -7.49 -0.42 1.04e-12 Breast cancer; CESC cis rs2243480 1.000 rs13310597 chr7:65598540 A/G cg13147721 chr7:65941812 NA -0.99 -9.4 -0.5 2.68e-18 Diabetic kidney disease; CESC cis rs6025261 0.761 rs3848695 chr20:55513254 C/T cg04763273 chr20:55502381 NA 0.3 5.09 0.3 6.76e-7 Verbal memory performance (delayed recall level); CESC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg08470875 chr2:26401718 FAM59B -0.62 -6.71 -0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.78 -10.94 -0.56 3.2e-23 Chronic sinus infection; CESC cis rs939574 0.790 rs114196239 chr2:220094307 G/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.88 7.38 0.41 2e-12 Platelet distribution width; CESC cis rs74181299 0.927 rs2723064 chr2:65279805 T/C cg05010058 chr2:65284262 CEP68 0.33 5.79 0.34 1.98e-8 Pulse pressure; CESC cis rs3916 0.955 rs35771722 chr12:121154000 A/G cg21892295 chr12:121157589 UNC119B -0.36 -5.26 -0.31 3.04e-7 Urinary metabolites (H-NMR features); CESC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg04369109 chr6:150039330 LATS1 -0.39 -5.45 -0.32 1.16e-7 Lung cancer; CESC cis rs56046484 0.871 rs71397837 chr15:85563561 G/A cg08123816 chr15:85640762 PDE8A -0.49 -5.71 -0.33 3.08e-8 Testicular germ cell tumor; CESC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg08888203 chr3:10149979 C3orf24 0.46 5.94 0.34 9.05e-9 Alzheimer's disease; CESC cis rs2120019 0.935 rs34835684 chr15:75331805 T/G cg09165964 chr15:75287851 SCAMP5 -0.78 -9.31 -0.5 5.02e-18 Blood trace element (Zn levels); CESC cis rs12477438 0.765 rs9710648 chr2:99673129 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg22974920 chr21:40686053 BRWD1 0.48 5.47 0.32 1.06e-7 Cognitive function; CESC cis rs11608355 0.545 rs918107 chr12:109904198 C/T cg05360138 chr12:110035743 NA -0.8 -8.76 -0.47 2.41e-16 Neuroticism; CESC cis rs7818345 0.967 rs13255946 chr8:19275354 T/C cg11303988 chr8:19266685 CSGALNACT1 0.32 5.85 0.34 1.43e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs7264396 0.623 rs761827 chr20:34207897 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -9.24 -0.49 8.07e-18 Total cholesterol levels; CESC cis rs12135062 1.000 rs12135062 chr1:3103312 A/C cg00254258 chr1:3105189 PRDM16 0.4 5.64 0.33 4.29e-8 Migraine; CESC cis rs9790314 0.560 rs4856701 chr3:161044106 G/T cg03342759 chr3:160939853 NMD3 -0.45 -6.53 -0.37 3.35e-10 Morning vs. evening chronotype; CESC cis rs6582630 0.638 rs12423236 chr12:38548162 G/A cg26384229 chr12:38710491 ALG10B -0.39 -5.19 -0.3 4.22e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs8062405 0.756 rs151182 chr16:28495752 C/T cg05966235 chr16:28915196 ATP2A1 0.36 5.18 0.3 4.41e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7674212 0.570 rs2711898 chr4:104063071 C/T cg16532752 chr4:104119610 CENPE -0.41 -5.69 -0.33 3.31e-8 Type 2 diabetes; CESC cis rs10992471 0.756 rs1121979 chr9:95140218 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -5.68 -0.33 3.52e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg18225595 chr11:63971243 STIP1 -0.39 -5.12 -0.3 5.94e-7 Platelet count; CESC cis rs7542091 0.704 rs12022221 chr1:210046178 A/C cg25204440 chr1:209979598 IRF6 0.37 5.16 0.3 4.95e-7 Monobrow; CESC cis rs728616 0.557 rs17107449 chr10:81715696 C/T cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.23 -0.36 1.86e-9 Schizophrenia; CESC cis rs1546924 0.669 rs6687953 chr1:112293512 A/G cg23955903 chr1:112298873 DDX20;C1orf183 0.42 5.42 0.32 1.33e-7 Body mass index; CESC cis rs17253792 0.822 rs112308750 chr14:56080073 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs738322 0.870 rs2277844 chr22:38577515 G/A cg25457927 chr22:38595422 NA 0.31 5.71 0.33 3.07e-8 Cutaneous nevi; CESC cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg23711669 chr6:146136114 FBXO30 1.02 15.96 0.7 1.2e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.954 rs7681544 chr4:120411255 T/C cg09307838 chr4:120376055 NA 0.92 12.96 0.62 4.27e-30 Corneal astigmatism; CESC cis rs2841277 0.509 rs11850949 chr14:105408827 A/C cg21017887 chr14:105400489 NA 0.44 7.15 0.4 8.35e-12 Rheumatoid arthritis; CESC trans rs9907295 0.818 rs4796112 chr17:34158726 A/G cg27663249 chr16:2801092 LOC100128788;SRRM2 0.61 6.2 0.36 2.18e-9 Fibroblast growth factor basic levels; CESC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.37 -0.54 2.24e-21 Alzheimer's disease; CESC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03576123 chr11:487126 PTDSS2 1.05 10.55 0.54 5.94e-22 Body mass index; CESC cis rs9291683 0.632 rs10939669 chr4:10045827 A/G cg00071950 chr4:10020882 SLC2A9 0.85 14.82 0.67 1.3e-36 Bone mineral density; CESC cis rs6570726 0.967 rs374728 chr6:145854598 T/A cg23711669 chr6:146136114 FBXO30 0.8 11.74 0.58 6.58e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg22920501 chr2:26401640 FAM59B -0.67 -8.01 -0.44 3.54e-14 Gut microbiome composition (summer); CESC cis rs67340775 0.834 rs13218875 chr6:27884012 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.87 5.97 0.34 7.6e-9 Lung cancer in ever smokers; CESC cis rs6424115 0.830 rs2502999 chr1:24198321 A/G cg15997130 chr1:24165203 NA 0.38 5.11 0.3 6.3e-7 Immature fraction of reticulocytes; CESC cis rs2243480 1.000 rs1979823 chr7:65704613 G/A cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC cis rs950027 0.620 rs1153857 chr15:45659095 G/T cg21132104 chr15:45694354 SPATA5L1 0.67 8.55 0.46 1.01e-15 Response to fenofibrate (adiponectin levels); CESC cis rs6502050 0.835 rs4789732 chr17:80131382 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.61e-10 Life satisfaction; CESC cis rs8072100 0.738 rs3736438 chr17:45486651 T/G cg25173405 chr17:45401733 C17orf57 -0.44 -5.48 -0.32 9.7e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs372883 0.648 rs1153292 chr21:30689195 G/T cg24692254 chr21:30365293 RNF160 -0.51 -6.47 -0.37 4.79e-10 Pancreatic cancer; CESC cis rs34779708 0.931 rs34375045 chr10:35362356 A/C cg03585969 chr10:35415529 CREM 0.73 9.22 0.49 9.87e-18 Inflammatory bowel disease;Crohn's disease; CESC cis rs1577917 0.959 rs34258068 chr6:86679449 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.92 -0.34 9.76e-9 Response to antipsychotic treatment; CESC cis rs9303401 0.573 rs35104446 chr17:57180234 A/C cg25039879 chr17:56429692 SUPT4H1 0.51 5.4 0.31 1.48e-7 Cognitive test performance; CESC cis rs7937682 0.889 rs1789359 chr11:111475995 T/A cg22437258 chr11:111473054 SIK2 0.72 9.69 0.51 3.38e-19 Primary sclerosing cholangitis; CESC cis rs7726839 0.561 rs56410216 chr5:583216 C/A cg09021430 chr5:549028 NA -0.43 -5.76 -0.33 2.29e-8 Obesity-related traits; CESC cis rs861020 0.630 rs592694 chr1:210009533 G/T cg05527609 chr1:210001259 C1orf107 0.75 10.05 0.53 2.48e-20 Orofacial clefts; CESC cis rs9914988 0.943 rs4795457 chr17:27087929 C/T cg20469991 chr17:27169893 C17orf63 -0.5 -5.66 -0.33 3.89e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC trans rs2727020 0.729 rs2204366 chr11:49349367 A/C cg15704280 chr7:45808275 SEPT13 0.88 14.64 0.67 5.8e-36 Coronary artery disease; CESC cis rs7818688 0.578 rs75025610 chr8:95838303 T/G cg16049864 chr8:95962084 TP53INP1 0.5 5.19 0.3 4.11e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs8044868 0.530 rs2287998 chr16:72059269 C/T cg01557791 chr16:72042693 DHODH 0.45 6.11 0.35 3.56e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs8070128 0.637 rs4925133 chr17:17884801 A/G cg09796270 chr17:17721594 SREBF1 0.38 5.18 0.3 4.32e-7 Total body bone mineral density; CESC trans rs7307889 0.793 rs55754310 chr12:5999906 T/G cg18407955 chr7:158110685 PTPRN2 -0.67 -6.11 -0.35 3.55e-9 Obesity-related traits; CESC trans rs116095464 0.558 rs56342538 chr5:225796 T/C cg00938859 chr5:1591904 SDHAP3 0.61 6.78 0.38 7.58e-11 Breast cancer; CESC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.72 0.33 2.87e-8 Menopause (age at onset); CESC cis rs4727963 0.846 rs1525472 chr7:122733976 A/G cg03640110 chr7:122635026 TAS2R16 0.37 5.76 0.33 2.32e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs12368653 0.525 rs1564374 chr12:58010163 C/T cg00700412 chr12:58011837 NA 0.42 6.64 0.38 1.8e-10 Multiple sclerosis; CESC cis rs73206853 0.925 rs28670753 chr12:110826463 C/T cg12870014 chr12:110450643 ANKRD13A 0.61 5.62 0.33 4.8e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2109514 0.792 rs4727831 chr7:116093983 A/G cg12739419 chr7:116140593 CAV2 -0.29 -5.26 -0.31 3.02e-7 Prevalent atrial fibrillation; CESC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg24531977 chr5:56204891 C5orf35 -1.0 -13.13 -0.63 1.09e-30 Initial pursuit acceleration; CESC cis rs11650494 0.908 rs73340399 chr17:47372743 G/C cg08112188 chr17:47440006 ZNF652 1.11 7.71 0.43 2.48e-13 Prostate cancer; CESC cis rs7208859 0.673 rs3816780 chr17:29161358 C/T cg19761014 chr17:28927070 LRRC37B2 0.58 5.09 0.3 6.95e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2952156 0.920 rs9303274 chr17:37836353 T/C cg00129232 chr17:37814104 STARD3 -0.78 -11.59 -0.58 2.06e-25 Asthma; CESC cis rs2299587 0.689 rs12546237 chr8:17797055 A/G cg08627089 chr8:17753878 FGL1 -0.41 -5.61 -0.33 5e-8 Economic and political preferences; CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg15383120 chr6:291909 DUSP22 -0.66 -8.33 -0.46 4.42e-15 Menopause (age at onset); CESC cis rs2243480 1.000 rs12698509 chr7:65418876 C/T cg12463550 chr7:65579703 CRCP 0.64 5.31 0.31 2.38e-7 Diabetic kidney disease; CESC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC cis rs735396 0.770 rs1169315 chr12:121443753 T/G cg15155738 chr12:121454335 C12orf43 0.44 5.08 0.3 7.18e-7 N-glycan levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25845374 chr2:119981187 STEAP3 0.49 6.05 0.35 4.92e-9 Gut microbiome composition (summer); CESC cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg01579765 chr21:45077557 HSF2BP -0.54 -9.55 -0.51 8.97e-19 Mean corpuscular volume; CESC trans rs1814175 0.615 rs4545557 chr11:50027329 A/C cg03929089 chr4:120376271 NA -0.91 -14.8 -0.67 1.58e-36 Height; CESC cis rs3096299 0.933 rs3096297 chr16:89453155 T/G cg08392591 chr16:89556376 ANKRD11 0.41 5.25 0.31 3.13e-7 Multiple myeloma (IgH translocation); CESC cis rs2625529 0.730 rs2957725 chr15:72248205 C/A cg16672083 chr15:72433130 SENP8 0.4 5.89 0.34 1.17e-8 Red blood cell count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26176469 chr17:28951361 LRRC37B2 -0.53 -7.1 -0.4 1.16e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs2207136 0.728 rs10948577 chr6:50827126 T/G cg06522515 chr3:184090630 THPO -0.38 -6.62 -0.38 2.03e-10 Myopia; CESC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg14298792 chr15:30685198 CHRFAM7A -0.45 -5.33 -0.31 2.05e-7 Huntington's disease progression; CESC cis rs2952156 0.959 rs2941504 chr17:37830900 A/G cg20243544 chr17:37824526 PNMT 0.59 7.41 0.41 1.73e-12 Asthma; CESC cis rs6060717 0.536 rs2425104 chr20:34312346 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -7.58 -0.42 5.86e-13 Hip circumference adjusted for BMI; CESC cis rs3806843 0.766 rs801399 chr5:140034844 C/T cg26395211 chr5:140044315 WDR55 0.41 5.58 0.32 5.83e-8 Depressive symptoms (multi-trait analysis); CESC cis rs637571 0.676 rs1151523 chr11:65665200 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.64 -8.3 -0.45 5.35e-15 Eosinophil percentage of white cells; CESC cis rs6594499 0.542 rs7722241 chr5:110460747 T/A cg04022379 chr5:110408740 TSLP 0.42 7.59 0.42 5.39e-13 Allergic disease (asthma, hay fever or eczema); CESC trans rs5756813 0.661 rs2071910 chr22:38204259 C/T cg19894588 chr14:64061835 NA -0.69 -8.53 -0.46 1.12e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs12530134 0.590 rs760492 chr6:170743989 A/G cg16453901 chr6:170730693 NA -0.75 -5.76 -0.33 2.38e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3820068 0.532 rs72645862 chr1:15920366 A/G cg17385448 chr1:15911702 AGMAT 0.42 6.77 0.38 8.35e-11 Systolic blood pressure; CESC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg22442454 chr1:209979470 IRF6 -0.43 -5.11 -0.3 6.05e-7 Cleft lip with or without cleft palate; CESC cis rs113835537 0.559 rs11227497 chr11:66269464 T/C cg24851651 chr11:66362959 CCS 0.42 5.14 0.3 5.46e-7 Airway imaging phenotypes; CESC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.43 0.5 2.2e-18 Menopause (age at onset); CESC cis rs1215050 0.527 rs1214998 chr4:99042878 T/G cg05340658 chr4:99064831 C4orf37 0.62 8.35 0.46 3.82e-15 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7937682 0.889 rs1784785 chr11:111483306 A/G cg22437258 chr11:111473054 SIK2 0.72 9.69 0.51 3.38e-19 Primary sclerosing cholangitis; CESC cis rs78456975 1.000 rs55761535 chr2:1561450 A/G cg01028140 chr2:1542097 TPO -0.5 -5.36 -0.31 1.78e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs1881797 0.872 rs12408686 chr1:247691141 C/T cg21399703 chr1:247681439 NA 0.62 8.24 0.45 8.01e-15 Acute lymphoblastic leukemia (childhood); CESC cis rs6032067 1.000 rs6032042 chr20:43815949 T/C cg10761708 chr20:43804764 PI3 0.53 6.39 0.37 7.37e-10 Blood protein levels; CESC trans rs1437396 0.586 rs6756777 chr2:55623734 C/T cg07921503 chr7:2445843 CHST12 -0.24 -6.05 -0.35 4.95e-9 Alcohol dependence; CESC cis rs35110281 0.720 rs162374 chr21:44927089 T/C cg01579765 chr21:45077557 HSF2BP 0.53 8.86 0.48 1.18e-16 Mean corpuscular volume; CESC cis rs863345 0.604 rs4373761 chr1:158464634 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs7617773 0.925 rs6442105 chr3:48182326 A/G cg11946769 chr3:48343235 NME6 -0.67 -8.92 -0.48 8.12e-17 Coronary artery disease; CESC cis rs10751667 0.666 rs7395321 chr11:940280 C/T cg01483505 chr11:975446 AP2A2 0.38 5.18 0.3 4.33e-7 Alzheimer's disease (late onset); CESC cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg25554036 chr4:6271136 WFS1 -0.55 -7.5 -0.42 9.83e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs400736 0.535 rs4418631 chr1:8174197 A/G cg25007680 chr1:8021821 PARK7 0.58 7.48 0.42 1.09e-12 Response to antidepressants and depression; CESC cis rs11997175 0.550 rs10954943 chr8:33815972 A/G ch.8.33884649F chr8:33765107 NA 0.59 7.47 0.42 1.2e-12 Body mass index; CESC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 9.25 0.49 7.87e-18 Platelet count; CESC cis rs8016982 0.674 rs8004096 chr14:81701082 T/G cg01989461 chr14:81687754 GTF2A1 0.68 10.12 0.53 1.49e-20 Schizophrenia; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg05215748 chr17:6898738 ALOX12 0.31 6.35 0.36 9.5e-10 Tonsillectomy; CESC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03051310 chr12:108954266 SART3 -0.54 -6.27 -0.36 1.43e-9 Gut microbiome composition (summer); CESC cis rs11792861 0.816 rs28361111 chr9:111761012 A/C cg13535736 chr9:111863775 C9orf5 -0.46 -6.06 -0.35 4.65e-9 Menarche (age at onset); CESC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg18230493 chr5:56204884 C5orf35 -0.69 -8.27 -0.45 6.71e-15 Initial pursuit acceleration; CESC cis rs9790314 0.690 rs6441354 chr3:160826404 A/G cg03342759 chr3:160939853 NMD3 -0.39 -5.19 -0.3 4.21e-7 Morning vs. evening chronotype; CESC trans rs17685 0.753 rs1104879 chr7:75685568 C/T cg19862616 chr7:65841803 NCRNA00174 0.81 11.86 0.59 2.7e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2243480 1.000 rs1701750 chr7:65467145 T/C cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC cis rs11722228 0.522 rs881641 chr4:10133747 G/A cg14348967 chr4:10160060 NA -0.4 -5.22 -0.31 3.63e-7 Gout;Urate levels;Serum uric acid levels; CESC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg26314531 chr2:26401878 FAM59B 0.85 9.23 0.49 8.65e-18 Gut microbiome composition (summer); CESC cis rs9467711 0.524 rs13216484 chr6:26762087 C/T cg21479132 chr6:26055353 NA 0.71 5.25 0.31 3.1e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9443645 0.545 rs10755377 chr6:79637925 T/C cg05283184 chr6:79620031 NA -0.36 -5.15 -0.3 4.97e-7 Intelligence (multi-trait analysis); CESC cis rs6541297 0.594 rs6672758 chr1:230303512 C/T cg20703242 chr1:230279135 GALNT2 0.36 5.49 0.32 9.4e-8 Coronary artery disease; CESC cis rs7212590 0.655 rs8067568 chr17:57999215 A/G cg20303301 chr17:57937339 TUBD1 -0.52 -5.47 -0.32 1.05e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs12136530 0.774 rs4911995 chr1:19765004 C/G cg01832549 chr1:19774989 CAPZB 0.46 6.34 0.36 9.85e-10 Lead levels in blood; CESC cis rs7246865 0.603 rs10423719 chr19:17211568 T/C cg19418318 chr19:17219073 MYO9B 0.35 5.96 0.34 8.02e-9 Reticulocyte fraction of red cells; CESC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.53 6.35 0.36 9.55e-10 Breast cancer; CESC cis rs921968 0.643 rs1516086 chr2:219431535 C/T cg02176678 chr2:219576539 TTLL4 0.39 6.68 0.38 1.4e-10 Mean corpuscular hemoglobin concentration; CESC cis rs1050631 0.960 rs1789503 chr18:33696865 T/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.44 5.68 0.33 3.58e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg24531977 chr5:56204891 C5orf35 -0.52 -6.38 -0.37 7.72e-10 Coronary artery disease; CESC cis rs1153858 1.000 rs4625670 chr15:45652926 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 5.97 0.34 7.62e-9 Homoarginine levels; CESC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.11 0.81 4.36e-62 Prudent dietary pattern; CESC cis rs11122272 0.701 rs743120 chr1:231531232 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs60843830 1.000 rs62114497 chr2:214837 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.74 9.25 0.49 7.87e-18 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7666738 0.515 rs28615369 chr4:98896858 C/T cg05340658 chr4:99064831 C4orf37 0.59 7.43 0.42 1.47e-12 Colonoscopy-negative controls vs population controls; CESC cis rs7589342 0.792 rs13426321 chr2:106500280 G/A cg16077055 chr2:106428750 NCK2 0.42 5.92 0.34 1.02e-8 Addiction; CESC cis rs861020 0.959 rs641348 chr1:209992043 A/G cg05527609 chr1:210001259 C1orf107 1.08 12.88 0.62 8.31e-30 Orofacial clefts; CESC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg24733560 chr20:60626293 TAF4 0.47 6.72 0.38 1.09e-10 Body mass index; CESC cis rs9393777 0.841 rs13191474 chr6:27413345 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.8 5.44 0.32 1.2e-7 Intelligence (multi-trait analysis); CESC cis rs2014572 0.933 rs8107516 chr19:57758445 A/G cg24459738 chr19:57751996 ZNF805 -0.53 -7.49 -0.42 1e-12 Hyperactive-impulsive symptoms; CESC cis rs35110281 0.807 rs2838325 chr21:45014284 A/T cg01579765 chr21:45077557 HSF2BP 0.49 8.64 0.47 5.58e-16 Mean corpuscular volume; CESC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg17376030 chr22:41985996 PMM1 0.59 6.53 0.37 3.39e-10 Vitiligo; CESC cis rs34779708 0.931 rs4934709 chr10:35339324 A/C cg04310649 chr10:35416472 CREM 0.51 6.09 0.35 3.98e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15921436 chr17:44337874 NA 0.46 6.37 0.36 8.2e-10 Fibrinogen levels; CESC cis rs3806843 0.712 rs2530244 chr5:140109155 A/G cg16179182 chr5:140090404 VTRNA1-1 0.38 5.06 0.3 7.77e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9581857 0.556 rs9581864 chr13:28041567 T/C cg01674679 chr13:27998804 GTF3A -0.55 -5.84 -0.34 1.51e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7927771 0.524 rs6485773 chr11:47763509 A/G cg18512352 chr11:47633146 NA 0.35 5.51 0.32 8.36e-8 Subjective well-being; CESC cis rs3784262 0.967 rs12910752 chr15:58314679 G/A cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.08 -0.3 7.25e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC trans rs9951602 0.512 rs4799244 chr18:76649763 T/C cg02800362 chr5:177631904 HNRNPAB 0.65 8.64 0.47 5.23e-16 Obesity-related traits; CESC cis rs6912958 0.781 rs9450723 chr6:88226641 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.5 6.63 0.38 1.83e-10 Monocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17834289 chr15:41878006 NA -0.47 -6.69 -0.38 1.35e-10 Gut microbiota (bacterial taxa); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg20151045 chr17:35414114 AATF -0.47 -6.12 -0.35 3.34e-9 Tetralogy of Fallot; CESC cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg17143192 chr8:8559678 CLDN23 0.71 8.34 0.46 4.02e-15 Obesity-related traits; CESC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 13.36 0.63 1.81e-31 Platelet count; CESC cis rs3749237 1.000 rs11130216 chr3:49736172 C/A cg03060546 chr3:49711283 APEH 0.64 7.5 0.42 9.67e-13 Resting heart rate; CESC cis rs7589342 0.839 rs35812588 chr2:106432201 C/T cg16077055 chr2:106428750 NCK2 0.52 7.44 0.42 1.42e-12 Addiction; CESC cis rs763014 0.931 rs2071982 chr16:630405 T/G cg07256732 chr16:621771 PIGQ -0.3 -5.13 -0.3 5.63e-7 Height; CESC cis rs763121 0.853 rs1056610 chr22:39080078 C/T cg21395723 chr22:39101663 GTPBP1 -0.46 -6.14 -0.35 2.93e-9 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04811621 chr4:40058985 LOC344967;N4BP2 -0.47 -6.26 -0.36 1.56e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg05564831 chr3:52568323 NT5DC2 0.46 7.39 0.41 1.91e-12 Electroencephalogram traits; CESC cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg11279151 chr3:101281821 RG9MTD1 -0.49 -5.42 -0.32 1.32e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg09359103 chr1:154839909 KCNN3 -0.65 -12.31 -0.6 7.76e-28 Prostate cancer; CESC cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg25019033 chr10:957182 NA -0.59 -6.29 -0.36 1.32e-9 Eosinophil percentage of granulocytes; CESC cis rs6061231 0.583 rs2427313 chr20:60970675 G/A cg24112000 chr20:60950667 NA -0.51 -7.14 -0.4 8.82e-12 Colorectal cancer; CESC cis rs1348850 0.632 rs11682717 chr2:178499240 C/G cg22681709 chr2:178499509 PDE11A -0.58 -9.05 -0.49 3.1e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2635047 0.615 rs2684833 chr18:44719428 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.34 -5.11 -0.3 6.16e-7 Educational attainment; CESC cis rs7772486 0.875 rs2748498 chr6:146319166 C/G cg05347473 chr6:146136440 FBXO30 0.52 6.92 0.39 3.32e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6831352 0.918 rs2602891 chr4:100043284 C/T cg13256891 chr4:100009986 ADH5 0.75 8.31 0.45 5.11e-15 Alcohol dependence; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04571941 chr7:5463284 TNRC18 0.47 6.27 0.36 1.45e-9 Asthma; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg05000123 chr14:20937394 PNP 0.49 6.49 0.37 4.13e-10 Weight; CESC cis rs9611565 0.513 rs739135 chr22:42090069 A/C cg03806693 chr22:41940476 POLR3H 1.13 13.07 0.63 1.86e-30 Vitiligo; CESC cis rs13392177 0.660 rs62185964 chr2:219073745 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.52 -6.44 -0.37 5.71e-10 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs1451375 0.617 rs11772714 chr7:50542843 G/A cg14593290 chr7:50529359 DDC -0.55 -6.4 -0.37 6.95e-10 Malaria; CESC cis rs2708240 0.577 rs2373270 chr7:147567042 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.4 -6.52 -0.37 3.5e-10 QT interval (drug interaction); CESC cis rs10465746 0.967 rs10493744 chr1:84444752 C/T cg10977910 chr1:84465055 TTLL7 -0.46 -6.27 -0.36 1.47e-9 Obesity-related traits; CESC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg24829409 chr8:58192753 C8orf71 -0.69 -7.54 -0.42 7.35e-13 Developmental language disorder (linguistic errors); CESC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg08847533 chr14:75593920 NEK9 0.84 13.98 0.65 1.18e-33 Height; CESC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg16278512 chr7:12443529 VWDE -0.56 -5.96 -0.34 8.1e-9 Coronary artery disease; CESC cis rs2180341 0.960 rs7766942 chr6:127691323 G/T cg24812749 chr6:127587940 RNF146 1.05 15.12 0.68 1.2e-37 Breast cancer; CESC cis rs616402 0.527 rs10779737 chr1:10580275 C/G cg17425144 chr1:10567563 PEX14 0.38 6.25 0.36 1.62e-9 Breast size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15803506 chr10:135125704 ZNF511 -0.64 -7.35 -0.41 2.52e-12 Gut microbiome composition (summer); CESC cis rs1499614 1.000 rs1882655 chr7:66147057 T/C cg12463550 chr7:65579703 CRCP -0.77 -6.0 -0.35 6.47e-9 Gout; CESC cis rs10242455 0.867 rs2222411 chr7:99310331 C/G cg07715041 chr7:99302981 CYP3A7 -0.43 -5.35 -0.31 1.9e-7 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02952494 chr16:1818699 MAPK8IP3 -0.55 -6.91 -0.39 3.71e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21012729 chr14:51297401 NIN 0.59 6.89 0.39 4.13e-11 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg05132306 chr1:1846340 CALML6 -0.32 -6.79 -0.39 7.19e-11 Body mass index; CESC cis rs8077577 0.945 rs9916193 chr17:18057215 C/G cg16794390 chr17:18148240 FLII 0.43 6.03 0.35 5.43e-9 Obesity-related traits; CESC cis rs8008758 1.000 rs915379 chr14:101689392 T/C cg26224664 chr14:101693935 NA -0.35 -5.36 -0.31 1.82e-7 Body mass index (alcohol intake interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27113480 chr11:33757875 CD59 0.56 6.25 0.36 1.61e-9 Gut microbiome composition (summer); CESC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg14983838 chr19:29218262 NA 0.47 5.9 0.34 1.1e-8 Methadone dose in opioid dependence; CESC cis rs11577318 0.853 rs7541333 chr1:26622889 C/T cg00852783 chr1:26633632 UBXN11 0.5 6.98 0.39 2.31e-11 Granulocyte percentage of myeloid white cells; CESC cis rs72772090 0.634 rs12186366 chr5:96088850 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -5.59 -0.32 5.76e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs116095464 0.558 rs10055354 chr5:243794 G/A cg10591111 chr5:226296 SDHA -0.52 -6.38 -0.36 7.94e-10 Breast cancer; CESC cis rs1975974 0.511 rs17052375 chr17:21743877 G/A cg18423549 chr17:21743878 NA -0.7 -10.07 -0.53 2.12e-20 Psoriasis; CESC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg05535760 chr7:792225 HEATR2 0.95 10.74 0.55 1.44e-22 Cerebrospinal P-tau181p levels; CESC cis rs12765878 1.000 rs3850671 chr10:105659387 T/C cg11005552 chr10:105648138 OBFC1 0.35 5.04 0.3 8.51e-7 Coronary artery disease; CESC cis rs7259376 0.775 rs2360621 chr19:22548669 C/T cg02657401 chr19:22469223 NA -0.26 -5.23 -0.31 3.48e-7 Menopause (age at onset); CESC cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg17366294 chr4:99064904 C4orf37 0.57 7.87 0.44 9.16e-14 Colonoscopy-negative controls vs population controls; CESC cis rs478304 0.903 rs61895677 chr11:65549415 T/C cg08755490 chr11:65554678 OVOL1 0.52 6.73 0.38 1.03e-10 Acne (severe); CESC cis rs6460942 0.591 rs4721079 chr7:12337742 A/G cg20607287 chr7:12443886 VWDE -0.59 -6.52 -0.37 3.54e-10 Coronary artery disease; CESC cis rs2072732 0.861 rs66693767 chr1:2955930 A/G cg15211996 chr1:2936768 ACTRT2 0.34 6.04 0.35 5.27e-9 Plateletcrit; CESC cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs208520 0.955 rs17644076 chr6:67004973 A/G cg07460842 chr6:66804631 NA -0.76 -9.13 -0.49 1.82e-17 Exhaled nitric oxide output; CESC cis rs3008870 1.000 rs912797 chr1:67413478 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg08859206 chr1:53392774 SCP2 -0.57 -7.24 -0.41 4.89e-12 Monocyte count; CESC cis rs6964587 0.967 rs34863529 chr7:91644341 C/G cg17063962 chr7:91808500 NA 0.54 7.28 0.41 3.78e-12 Breast cancer; CESC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg10295955 chr4:187884368 NA 1.09 22.64 0.81 6.97e-64 Lobe attachment (rater-scored or self-reported); CESC cis rs5758511 0.680 rs5758681 chr22:42645091 A/G cg00645731 chr22:42541494 CYP2D7P1 0.57 8.53 0.46 1.12e-15 Birth weight; CESC cis rs910316 0.967 rs11159116 chr14:75550584 G/T cg11812906 chr14:75593930 NEK9 0.89 15.02 0.68 2.63e-37 Height; CESC cis rs829883 0.639 rs829898 chr12:98857675 A/C cg25150519 chr12:98850993 NA 0.87 14.78 0.67 1.88e-36 Colorectal adenoma (advanced); CESC cis rs1707322 0.691 rs28495425 chr1:46187320 T/G cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.6 0.33 5.29e-8 Bipolar disorder; CESC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.520 rs55967509 chr8:57992448 A/G cg24829409 chr8:58192753 C8orf71 -0.49 -5.88 -0.34 1.21e-8 Developmental language disorder (linguistic errors); CESC cis rs9815354 0.812 rs61661916 chr3:41921915 T/C cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.93e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg17179660 chr6:151773299 C6orf211;RMND1 -0.42 -5.47 -0.32 1.05e-7 Menarche (age at onset); CESC cis rs7772486 0.754 rs702323 chr6:146008274 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.73 -0.38 1.03e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg06221963 chr1:154839813 KCNN3 -0.66 -11.39 -0.57 1.03e-24 Prostate cancer; CESC cis rs11122272 0.614 rs78172021 chr1:231525160 A/T cg06096015 chr1:231504339 EGLN1 0.43 6.13 0.35 3.23e-9 Hemoglobin concentration; CESC cis rs2658782 0.789 rs1456238 chr11:93117370 G/C cg15737290 chr11:93063684 CCDC67 0.5 6.19 0.36 2.26e-9 Pulmonary function decline; CESC cis rs7267979 1.000 rs2297496 chr20:25295787 T/C cg08601574 chr20:25228251 PYGB -0.39 -5.61 -0.33 4.99e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg11644478 chr21:40555479 PSMG1 1.02 16.31 0.71 7.16e-42 Cognitive function; CESC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg12034118 chr1:209979487 IRF6 0.46 5.63 0.33 4.54e-8 Cleft lip with or without cleft palate; CESC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg17971929 chr21:40555470 PSMG1 -0.59 -7.89 -0.44 7.83e-14 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03115072 chr11:207155 BET1L;RIC8A 0.55 6.46 0.37 5.04e-10 Gut microbiome composition (summer); CESC cis rs4689388 0.581 rs4476672 chr4:6281496 A/G cg25554036 chr4:6271136 WFS1 0.52 6.56 0.37 2.86e-10 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2204008 0.837 rs55962152 chr12:38234281 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.85 0.52 1.07e-19 Bladder cancer; CESC cis rs1278769 0.735 rs12585036 chr13:113535741 C/T cg00823993 chr13:113535758 ATP11A 0.59 7.68 0.43 3e-13 Interstitial lung disease; CESC cis rs67311347 1.000 rs7625736 chr3:40441345 C/G cg09455208 chr3:40491958 NA -0.43 -7.47 -0.42 1.14e-12 Renal cell carcinoma; CESC cis rs6076065 0.748 rs6048779 chr20:23374709 C/G cg11657817 chr20:23433608 CST11 0.4 6.06 0.35 4.71e-9 Facial morphology (factor 15, philtrum width); CESC cis rs6570726 1.000 rs951143 chr6:145932576 C/T cg23711669 chr6:146136114 FBXO30 0.71 10.56 0.54 5.7e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg08736216 chr1:53307985 ZYG11A -0.39 -6.65 -0.38 1.65e-10 Monocyte count; CESC cis rs1832871 0.672 rs9457344 chr6:158742043 C/T cg07165851 chr6:158734300 TULP4 0.59 6.41 0.37 6.63e-10 Height; CESC cis rs11190604 0.943 rs113791644 chr10:102324330 T/G cg07080220 chr10:102295463 HIF1AN 0.59 5.64 0.33 4.42e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg03806693 chr22:41940476 POLR3H -1.23 -16.62 -0.71 5.4e-43 Vitiligo; CESC cis rs7131987 0.903 rs11050162 chr12:29420054 T/G cg09582351 chr12:29534625 ERGIC2 -0.34 -5.39 -0.31 1.57e-7 QT interval; CESC cis rs829883 0.724 rs1439774 chr12:98907692 C/T cg25150519 chr12:98850993 NA -0.64 -7.9 -0.44 7.53e-14 Colorectal adenoma (advanced); CESC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg12463550 chr7:65579703 CRCP 0.57 7.18 0.4 6.93e-12 Aortic root size; CESC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg12516959 chr21:47718080 NA 0.41 5.97 0.34 7.7e-9 Testicular germ cell tumor; CESC cis rs9399401 0.667 rs34018047 chr6:142790873 G/C cg03128060 chr6:142623767 GPR126 0.31 5.15 0.3 5.12e-7 Chronic obstructive pulmonary disease; CESC cis rs12477438 0.520 rs4347885 chr2:99804007 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.67 0.61 4.31e-29 Chronic sinus infection; CESC cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg25019033 chr10:957182 NA -0.59 -5.85 -0.34 1.43e-8 Eosinophil percentage of granulocytes; CESC cis rs9611565 0.559 rs739136 chr22:42100275 C/T cg17376030 chr22:41985996 PMM1 0.73 7.76 0.43 1.89e-13 Vitiligo; CESC cis rs6089584 0.566 rs6061401 chr20:60607482 G/A cg24733560 chr20:60626293 TAF4 0.49 7.28 0.41 3.82e-12 Body mass index; CESC cis rs9787249 0.957 rs3738673 chr1:40204823 C/T cg19912559 chr1:40204330 PPIE 0.43 6.59 0.38 2.3e-10 Blood protein levels; CESC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg11764359 chr7:65958608 NA -0.94 -15.49 -0.69 5.65e-39 Aortic root size; CESC cis rs6693567 0.565 rs1260407 chr1:150306125 T/C cg09579323 chr1:150459698 TARS2 0.49 6.28 0.36 1.35e-9 Migraine; CESC cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.8 0.48 1.82e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4849845 0.637 rs2028147 chr2:121058412 C/T cg24070213 chr2:121070622 NA -0.4 -5.71 -0.33 3.1e-8 Mean platelet volume; CESC cis rs1775715 0.835 rs1419169 chr10:32257204 C/G cg18675610 chr10:32216311 ARHGAP12 0.32 5.11 0.3 6.16e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs12458462 0.859 rs35493271 chr18:77448793 G/T cg11879182 chr18:77439856 CTDP1 0.87 13.93 0.65 1.87e-33 Monocyte count; CESC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg11494091 chr17:61959527 GH2 0.72 12.33 0.6 6.57e-28 Prudent dietary pattern; CESC cis rs7795096 0.806 rs10261999 chr7:151540659 G/T cg17008978 chr7:151542804 PRKAG2 0.39 7.25 0.41 4.53e-12 Bipolar disorder (age of onset and psychotic symptoms); CESC cis rs72781680 0.898 rs12619525 chr2:23999565 G/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs6499255 0.951 rs9921045 chr16:69708698 C/T cg15192750 chr16:69999425 NA 0.47 5.4 0.31 1.5e-7 IgE levels; CESC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg05025164 chr4:1340916 KIAA1530 0.86 11.6 0.58 1.94e-25 Longevity; CESC cis rs7116495 0.609 rs501308 chr11:71581325 C/G cg10381502 chr11:71823885 C11orf51 1.06 7.24 0.41 4.95e-12 Severe influenza A (H1N1) infection; CESC cis rs2562152 0.744 rs216597 chr16:106777 G/C cg02949481 chr16:131562 MPG 0.55 6.14 0.35 3e-9 Glioblastoma; CESC cis rs9905704 0.681 rs2108911 chr17:56570500 C/T cg12560992 chr17:57184187 TRIM37 -0.63 -5.79 -0.34 1.99e-8 Testicular germ cell tumor; CESC cis rs9796 0.621 rs1659228 chr15:41471978 A/G cg20272979 chr15:41787780 ITPKA 0.33 5.07 0.3 7.6e-7 Menopause (age at onset); CESC trans rs11098499 0.954 rs11098524 chr4:120390032 A/G cg25214090 chr10:38739885 LOC399744 0.58 7.31 0.41 3.08e-12 Corneal astigmatism; CESC cis rs1801251 0.963 rs13021246 chr2:233623111 T/C cg08000102 chr2:233561755 GIGYF2 0.67 9.48 0.5 1.53e-18 Coronary artery disease; CESC cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg11752832 chr7:134001865 SLC35B4 0.54 7.06 0.4 1.46e-11 Mean platelet volume; CESC cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg11752832 chr7:134001865 SLC35B4 0.54 7.0 0.4 2.04e-11 Mean platelet volume; CESC cis rs9362426 1.000 rs242271 chr6:88082029 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.48 5.57 0.32 6.22e-8 Depressive episodes in bipolar disorder; CESC cis rs4664308 0.967 rs7563607 chr2:160910215 C/G cg03641300 chr2:160917029 PLA2R1 -0.68 -10.17 -0.53 9.82e-21 Idiopathic membranous nephropathy; CESC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg00166722 chr3:10149974 C3orf24 0.55 7.09 0.4 1.21e-11 Alzheimer's disease; CESC cis rs6546550 0.901 rs1979214 chr2:70137498 G/C cg02498382 chr2:70120550 SNRNP27 -0.38 -6.6 -0.38 2.18e-10 Prevalent atrial fibrillation; CESC cis rs7789940 0.904 rs61294900 chr7:75937212 A/T cg10167463 chr7:75959203 YWHAG -0.51 -6.04 -0.35 5.31e-9 Multiple sclerosis; CESC cis rs2486288 0.656 rs2461705 chr15:45570241 A/G cg21132104 chr15:45694354 SPATA5L1 -0.6 -6.98 -0.39 2.36e-11 Glomerular filtration rate; CESC cis rs12476592 0.602 rs7570031 chr2:63792265 A/G cg17519650 chr2:63277830 OTX1 -0.49 -5.45 -0.32 1.16e-7 Childhood ear infection; CESC cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.41 0.46 2.57e-15 Colonoscopy-negative controls vs population controls; CESC cis rs727505 0.954 rs2170352 chr7:124605584 G/A cg23710748 chr7:124431027 NA -0.45 -7.08 -0.4 1.27e-11 Lewy body disease; CESC cis rs963731 0.522 rs1454225 chr2:39228632 T/G cg04010122 chr2:39346883 SOS1 -0.69 -5.14 -0.3 5.41e-7 Corticobasal degeneration; CESC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg08736216 chr1:53307985 ZYG11A -0.41 -6.96 -0.39 2.62e-11 Monocyte count; CESC cis rs523522 0.571 rs11065120 chr12:120875456 C/T cg12219531 chr12:120966889 COQ5 0.63 7.12 0.4 1.02e-11 High light scatter reticulocyte count; CESC cis rs10911251 0.546 rs1051473 chr1:183114146 T/C ch.1.3577855R chr1:183094577 LAMC1 0.81 12.18 0.6 2.1e-27 Colorectal cancer; CESC cis rs6460942 0.597 rs4721108 chr7:12535247 C/T cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs10504229 0.516 rs1866994 chr8:57990092 A/C cg24829409 chr8:58192753 C8orf71 -0.36 -5.11 -0.3 6.21e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26565578 chr12:10766330 MAGOHB -0.55 -6.74 -0.38 9.95e-11 Gut microbiome composition (summer); CESC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg18876405 chr7:65276391 NA -0.5 -5.91 -0.34 1.05e-8 Aortic root size; CESC cis rs7727544 0.735 rs272881 chr5:131669264 G/A cg07395648 chr5:131743802 NA -0.46 -6.06 -0.35 4.78e-9 Blood metabolite levels; CESC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg26354017 chr1:205819088 PM20D1 0.82 12.51 0.61 1.53e-28 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05049681 chr22:20708652 NA -0.56 -7.1 -0.4 1.15e-11 Gut microbiome composition (summer); CESC cis rs6496667 0.533 rs7173201 chr15:90991195 A/T cg10434728 chr15:90938212 IQGAP1 0.31 5.45 0.32 1.13e-7 Rheumatoid arthritis; CESC cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1983891 0.955 rs2025645 chr6:41519654 A/G cg20194872 chr6:41519635 FOXP4 0.58 8.35 0.46 3.92e-15 Prostate cancer; CESC cis rs3892630 0.878 rs6510277 chr19:33183669 C/A cg22980127 chr19:33182716 NUDT19 1.02 11.67 0.58 1.15e-25 Red blood cell traits; CESC cis rs6061231 1.000 rs11696991 chr20:60959694 G/T cg24112000 chr20:60950667 NA -0.67 -9.74 -0.51 2.4e-19 Colorectal cancer; CESC trans rs9470794 0.790 rs10947715 chr6:38147910 C/G cg16078060 chr6:74079719 OOEP -0.66 -6.02 -0.35 5.82e-9 Type 2 diabetes; CESC cis rs1707322 0.752 rs11211173 chr1:46219376 C/T cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.66 0.33 3.97e-8 Bipolar disorder; CESC cis rs3540 0.533 rs12708585 chr15:91052285 C/T cg22089800 chr15:90895588 ZNF774 -0.63 -8.44 -0.46 2.09e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs826838 0.967 rs2069211 chr12:39128892 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs2249625 0.523 rs2496552 chr6:72853042 T/C cg18830697 chr6:72922368 RIMS1 -0.42 -6.21 -0.36 2e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.83 8.17 0.45 1.25e-14 Platelet count; CESC cis rs12765878 1.000 rs3814220 chr10:105647300 A/G cg11005552 chr10:105648138 OBFC1 0.35 5.18 0.3 4.5e-7 Coronary artery disease; CESC cis rs924607 1.000 rs4045344 chr5:595870 G/T cg09021430 chr5:549028 NA 0.39 6.73 0.38 1.06e-10 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg20476274 chr7:133979776 SLC35B4 0.68 10.08 0.53 1.98e-20 Mean platelet volume; CESC cis rs2777491 0.574 rs11635906 chr15:41779260 A/G cg02330683 chr15:41787940 ITPKA 0.44 5.24 0.31 3.31e-7 Ulcerative colitis; CESC cis rs11785400 1.000 rs9720653 chr8:143731939 T/G cg10596483 chr8:143751796 JRK 0.43 5.54 0.32 7.2e-8 Schizophrenia; CESC cis rs9987353 0.566 rs6998368 chr8:9070288 G/C cg15556689 chr8:8085844 FLJ10661 -0.56 -6.41 -0.37 6.66e-10 Recombination measurement; CESC cis rs2228479 0.850 rs12600051 chr16:89992072 G/T cg00800038 chr16:89945340 TCF25 -0.92 -7.39 -0.41 1.97e-12 Skin colour saturation; CESC cis rs798766 0.953 rs798751 chr4:1719572 A/G cg07041428 chr4:1763019 NA -0.39 -5.54 -0.32 7.44e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg19912559 chr1:40204330 PPIE 0.42 6.48 0.37 4.37e-10 Blood protein levels; CESC cis rs9929218 0.954 rs2961 chr16:68818903 T/C cg02972257 chr16:68554789 NA 0.47 5.64 0.33 4.46e-8 Colorectal cancer; CESC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg07701084 chr6:150067640 NUP43 0.47 6.67 0.38 1.46e-10 Lung cancer; CESC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg06074448 chr4:187884817 NA -0.36 -5.21 -0.3 3.82e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.04 0.4 1.6e-11 Height; CESC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg08968635 chr6:28129556 ZNF389 0.4 5.21 0.3 3.88e-7 Depression; CESC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.38 0.54 2.06e-21 Prudent dietary pattern; CESC cis rs919433 0.963 rs13033821 chr2:198173536 T/G cg10820045 chr2:198174542 NA -0.38 -5.16 -0.3 4.87e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2262909 0.962 rs7255049 chr19:22213111 A/G cg11619707 chr19:22235551 ZNF257 -0.34 -5.8 -0.34 1.86e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs6754311 0.597 rs2278544 chr2:136546110 A/G cg15123519 chr2:136567270 LCT 0.31 5.22 0.31 3.65e-7 Mosquito bite size; CESC cis rs9300255 0.569 rs1716170 chr12:123716513 C/T cg00376283 chr12:123451042 ABCB9 0.72 8.89 0.48 9.37e-17 Neutrophil percentage of white cells; CESC cis rs2952156 0.920 rs2952152 chr17:37832735 T/C cg00129232 chr17:37814104 STARD3 -0.76 -10.51 -0.54 7.76e-22 Asthma; CESC cis rs6582630 0.555 rs7301250 chr12:38596244 G/T cg13010199 chr12:38710504 ALG10B 0.53 6.8 0.39 6.93e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs7872515 0.838 rs7860518 chr9:94826465 C/T cg01248375 chr9:94877805 SPTLC1 0.49 5.25 0.31 3.08e-7 Bipolar disorder and schizophrenia; CESC cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg21573476 chr21:45109991 RRP1B -0.43 -6.19 -0.36 2.29e-9 Mean corpuscular volume; CESC cis rs10781543 0.839 rs10870071 chr9:139382184 T/C cg14019695 chr9:139328340 INPP5E 0.35 5.31 0.31 2.29e-7 Monocyte percentage of white cells; CESC cis rs9649465 0.967 rs13239184 chr7:123314618 G/T cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.44e-7 Migraine; CESC cis rs28374715 0.662 rs522063 chr15:41476209 A/G cg18705301 chr15:41695430 NDUFAF1 0.73 9.55 0.51 8.88e-19 Ulcerative colitis; CESC cis rs3126085 0.825 rs11204933 chr1:152172185 C/T cg26876637 chr1:152193138 HRNR 0.45 5.11 0.3 6.05e-7 Atopic dermatitis; CESC cis rs113835537 0.529 rs75683511 chr11:66275026 A/G cg22134325 chr11:66188745 NPAS4 0.45 7.09 0.4 1.2e-11 Airway imaging phenotypes; CESC cis rs7937682 0.924 rs501089 chr11:111502479 G/T cg09085632 chr11:111637200 PPP2R1B 0.98 13.74 0.65 8.22e-33 Primary sclerosing cholangitis; CESC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg24060327 chr5:131705240 SLC22A5 -0.76 -10.61 -0.55 3.71e-22 Breast cancer; CESC cis rs6466055 0.777 rs2299319 chr7:104877916 C/T cg04380332 chr7:105027541 SRPK2 -0.38 -5.11 -0.3 6.3e-7 Schizophrenia; CESC trans rs9858542 0.953 rs34363169 chr3:49537712 G/A cg21659725 chr3:3221576 CRBN -0.55 -6.49 -0.37 4.22e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg05552183 chr6:42928497 GNMT 0.74 11.61 0.58 1.86e-25 Alzheimer's disease in APOE e4+ carriers; CESC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg27286337 chr10:134555280 INPP5A 0.7 8.15 0.45 1.5e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs5769765 1.000 rs5769764 chr22:50270784 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs4563143 0.675 rs17498203 chr19:29279734 G/T cg04546413 chr19:29218101 NA 0.54 7.17 0.4 7.28e-12 Methadone dose in opioid dependence; CESC cis rs10927875 0.578 rs10927859 chr1:16141862 C/T cg21385522 chr1:16154831 NA -1.03 -17.12 -0.72 9.61e-45 Dilated cardiomyopathy; CESC cis rs6754311 0.597 rs6760329 chr2:136544752 A/G cg15123519 chr2:136567270 LCT 0.3 5.24 0.31 3.25e-7 Mosquito bite size; CESC cis rs8060686 0.641 rs12445533 chr16:68082527 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.16 -0.35 2.65e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07684353 chr15:59664799 MYO1E -0.44 -6.17 -0.35 2.54e-9 Gambling; CESC cis rs6762477 0.748 rs2073726 chr3:50223593 T/A cg24308560 chr3:49941425 MST1R 0.4 5.12 0.3 5.76e-7 Menarche (age at onset); CESC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg24846343 chr22:24311635 DDTL 0.64 10.93 0.56 3.44e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs35110281 0.641 rs4818858 chr21:45083097 C/T cg21573476 chr21:45109991 RRP1B 0.57 8.15 0.45 1.43e-14 Mean corpuscular volume; CESC cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg12463550 chr7:65579703 CRCP 0.57 5.36 0.31 1.78e-7 Diabetic kidney disease; CESC cis rs4555082 0.834 rs2735825 chr14:105710900 G/A cg06808227 chr14:105710500 BRF1 -0.52 -5.7 -0.33 3.11e-8 Mean platelet volume;Platelet distribution width; CESC cis rs11758351 0.660 rs11753131 chr6:26219384 G/A cg01420254 chr6:26195488 NA 0.77 8.49 0.46 1.48e-15 Gout;Renal underexcretion gout; CESC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg07701084 chr6:150067640 NUP43 0.43 5.74 0.33 2.56e-8 Lung cancer; CESC cis rs1832871 0.672 rs1342211 chr6:158759496 G/T cg07165851 chr6:158734300 TULP4 0.6 6.58 0.37 2.57e-10 Height; CESC cis rs12711979 0.509 rs10195596 chr2:3824222 T/G cg17052675 chr2:3827356 NA -0.66 -11.02 -0.56 1.71e-23 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs7546094 1.000 rs6682737 chr1:113136229 T/C cg22162597 chr1:113214053 CAPZA1 0.38 5.73 0.33 2.69e-8 Platelet distribution width; CESC cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg13902645 chr11:5959945 NA 0.54 7.38 0.41 2.08e-12 DNA methylation (variation); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09658438 chr12:56693554 CS 0.48 6.28 0.36 1.37e-9 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14912727 chr1:36916005 OSCP1 0.64 7.62 0.42 4.51e-13 Gut microbiome composition (summer); CESC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg19257562 chr1:2043853 PRKCZ 0.42 6.76 0.38 8.69e-11 Height; CESC cis rs9362426 1.000 rs9294377 chr6:88084839 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.48 5.98 0.34 7.16e-9 Depressive episodes in bipolar disorder; CESC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg08470875 chr2:26401718 FAM59B -0.73 -7.99 -0.44 4.05e-14 Gut microbiome composition (summer); CESC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg08859206 chr1:53392774 SCP2 -0.57 -7.5 -0.42 9.72e-13 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16727585 chr12:109592662 ACACB 0.55 6.27 0.36 1.49e-9 Gut microbiome composition (summer); CESC cis rs3820928 0.874 rs55743026 chr2:227802813 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -5.61 -0.33 5.03e-8 Pulmonary function; CESC cis rs941873 0.868 rs12780295 chr10:81115438 G/A cg08514558 chr10:81106712 PPIF 0.33 5.8 0.34 1.85e-8 Height; CESC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg22535103 chr8:58192502 C8orf71 -0.78 -8.64 -0.47 5.58e-16 Developmental language disorder (linguistic errors); CESC cis rs67311347 1.000 rs11706148 chr3:40407243 A/C cg24209194 chr3:40518798 ZNF619 0.5 6.25 0.36 1.67e-9 Renal cell carcinoma; CESC cis rs1864400 0.690 rs7098237 chr10:43740513 T/A cg07801480 chr10:43725741 RASGEF1A -0.41 -5.21 -0.3 3.75e-7 Hirschsprung disease; CESC cis rs1152591 0.811 rs1255986 chr14:64655161 A/G cg21174375 chr14:64681225 SYNE2 -0.48 -6.51 -0.37 3.78e-10 Atrial fibrillation; CESC trans rs7246657 0.943 rs2112923 chr19:37940327 C/T cg01833234 chr11:6592585 DNHD1 0.52 6.0 0.35 6.5e-9 Coronary artery calcification; CESC cis rs35123781 1.000 rs682164 chr5:139058589 A/G cg10513866 chr5:139070639 NA 0.36 5.29 0.31 2.55e-7 Schizophrenia; CESC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 22.14 0.81 3.43e-62 Prudent dietary pattern; CESC cis rs2718058 0.519 rs2598054 chr7:37884640 C/T cg24998770 chr7:37888106 TXNDC3 0.35 5.39 0.31 1.58e-7 Alzheimer's disease (late onset); CESC trans rs2415984 0.811 rs7159042 chr14:46854616 T/C cg14945696 chr3:52713679 PBRM1 -0.39 -6.05 -0.35 4.98e-9 Number of children ever born; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01512265 chr20:34359908 PHF20 -0.59 -7.14 -0.4 9.04e-12 Gut microbiome composition (summer); CESC cis rs1707322 0.963 rs6429581 chr1:46319096 G/A cg05343316 chr1:45956843 TESK2 0.49 5.96 0.34 7.98e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6732160 0.845 rs72807999 chr2:73391695 T/C cg01422370 chr2:73384389 NA 0.44 7.58 0.42 5.72e-13 Intelligence (multi-trait analysis); CESC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.0 -0.39 2.14e-11 Total body bone mineral density; CESC cis rs5758659 0.682 rs133306 chr22:42396150 G/A cg04733989 chr22:42467013 NAGA 0.44 5.81 0.34 1.78e-8 Cognitive function; CESC cis rs7833790 0.553 rs9693128 chr8:82706128 A/G cg17211192 chr8:82754475 SNX16 -0.6 -8.07 -0.44 2.51e-14 Diastolic blood pressure; CESC cis rs6714710 0.603 rs11680321 chr2:98379267 C/T cg26665480 chr2:98280029 ACTR1B 0.54 7.64 0.42 3.91e-13 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs11676348 0.772 rs11676275 chr2:218944808 G/A cg00012203 chr2:219082015 ARPC2 -0.43 -5.27 -0.31 2.8e-7 Ulcerative colitis; CESC cis rs3806843 0.900 rs2531341 chr5:140130894 C/T cg26395211 chr5:140044315 WDR55 0.39 5.09 0.3 6.79e-7 Depressive symptoms (multi-trait analysis); CESC cis rs11931598 0.513 rs3857170 chr4:7003366 A/T cg19539972 chr4:7069911 GRPEL1 0.39 5.35 0.31 1.93e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg06108461 chr20:60628389 TAF4 -0.57 -7.54 -0.42 7.57e-13 Body mass index; CESC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg05863683 chr7:1912471 MAD1L1 0.38 5.54 0.32 7.43e-8 Bipolar disorder and schizophrenia; CESC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg07395648 chr5:131743802 NA 0.42 5.46 0.32 1.09e-7 Breast cancer; CESC cis rs2880765 0.835 rs7169429 chr15:86036648 C/T cg19183879 chr15:85880815 NA -0.25 -5.18 -0.3 4.31e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04784263 chr16:57318624 PLLP 0.55 6.29 0.36 1.32e-9 Gut microbiome composition (summer); CESC cis rs34779708 0.931 rs13376801 chr10:35370443 T/C cg04310649 chr10:35416472 CREM -0.52 -6.4 -0.37 7.03e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs1729951 0.575 rs10935213 chr3:136693459 A/G cg15507776 chr3:136538369 TMEM22 0.41 5.07 0.3 7.48e-7 Neuroticism; CESC cis rs17253792 0.822 rs75897560 chr14:56090965 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs1035144 0.510 rs12432357 chr14:81299468 A/G cg06600135 chr14:81408086 NA -0.58 -7.75 -0.43 2.03e-13 Male sexual orientation; CESC cis rs6424115 0.830 rs2502993 chr1:24201262 A/G cg10978503 chr1:24200527 CNR2 0.33 6.64 0.38 1.73e-10 Immature fraction of reticulocytes; CESC cis rs9486715 0.838 rs4839840 chr6:96941149 T/C cg18709589 chr6:96969512 KIAA0776 0.46 6.56 0.37 2.79e-10 Headache; CESC cis rs8062405 0.965 rs56040780 chr16:28861881 C/T cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg12463550 chr7:65579703 CRCP 0.57 7.2 0.4 6.12e-12 Aortic root size; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03734322 chr17:1532856 SLC43A2 0.49 6.68 0.38 1.36e-10 Systemic lupus erythematosus; CESC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.7 -0.33 3.25e-8 Total body bone mineral density; CESC cis rs10208940 0.764 rs34744266 chr2:68782606 G/A cg12452813 chr2:68675892 NA 0.52 5.16 0.3 4.88e-7 Urate levels in lean individuals; CESC cis rs1018836 0.923 rs7840846 chr8:91565501 T/A cg16814680 chr8:91681699 NA -0.72 -10.29 -0.53 4.01e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs3733585 0.673 rs7376948 chr4:9954708 G/A cg11266682 chr4:10021025 SLC2A9 -0.58 -10.94 -0.56 3.1e-23 Cleft plate (environmental tobacco smoke interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06544376 chr20:18548101 LOC388789 -0.53 -7.18 -0.4 6.99e-12 Fibrinogen levels; CESC cis rs7188697 0.922 rs37051 chr16:58558102 C/T cg21335942 chr16:58549945 SETD6 0.46 5.46 0.32 1.11e-7 QT interval; CESC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg24060327 chr5:131705240 SLC22A5 -0.78 -10.95 -0.56 2.89e-23 Blood metabolite levels; CESC cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs75477785 0.590 rs10779521 chr1:210253508 G/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.95 6.41 0.37 6.82e-10 Cleft lip with or without cleft palate; CESC cis rs1215050 0.791 rs649866 chr4:98738826 T/C cg05340658 chr4:99064831 C4orf37 0.53 6.93 0.39 3.26e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs96067 0.711 rs4653164 chr1:36627542 A/G cg24686825 chr1:36642396 MAP7D1 0.42 5.61 0.33 5.18e-8 Corneal structure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20513643 chr12:49393348 DDN -0.47 -6.59 -0.38 2.4e-10 Gut microbiota (bacterial taxa); CESC cis rs5758343 1 rs5758343 chr22:41816652 A/T cg17376030 chr22:41985996 PMM1 -0.74 -7.8 -0.43 1.42e-13 Allergic disease (asthma, hay fever or eczema); CESC trans rs61148964 0.826 rs11913459 chr22:37228603 G/A cg12583095 chr10:92618141 HTR7 -0.65 -6.01 -0.35 5.96e-9 Scarlet fever; CESC cis rs10189230 0.546 rs6727259 chr2:222358292 C/G cg14652038 chr2:222343519 EPHA4 -0.3 -5.53 -0.32 7.6e-8 Urate levels in lean individuals; CESC cis rs36051895 0.659 rs3780367 chr9:5068755 T/G cg02405213 chr9:5042618 JAK2 -0.51 -6.31 -0.36 1.19e-9 Pediatric autoimmune diseases; CESC cis rs12431939 0.947 rs56156789 chr14:51633899 C/G cg23942311 chr14:51606299 NA -0.42 -5.16 -0.3 4.89e-7 Cancer; CESC cis rs16910800 0.731 rs55908012 chr11:23191640 G/A cg20040320 chr11:23191996 NA -0.67 -6.66 -0.38 1.53e-10 Cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22238707 chr1:28833064 SNHG3-RCC1;SNHG3 -0.57 -6.27 -0.36 1.47e-9 Gut microbiome composition (summer); CESC cis rs10242455 0.702 rs73711293 chr7:99081595 C/T cg18809830 chr7:99032528 PTCD1 -0.64 -5.07 -0.3 7.31e-7 Blood metabolite levels; CESC trans rs7618501 1.000 rs3811696 chr3:49761605 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -8.48 -0.46 1.62e-15 Intelligence (multi-trait analysis); CESC cis rs17376456 0.542 rs10476588 chr5:93208330 C/T cg21475434 chr5:93447410 FAM172A -0.53 -5.33 -0.31 2.15e-7 Diabetic retinopathy; CESC cis rs7605827 0.930 rs3792578 chr2:15534642 G/A cg19274914 chr2:15703543 NA 0.35 6.39 0.37 7.22e-10 Educational attainment (years of education); CESC cis rs17376456 1.000 rs66978370 chr5:93553633 G/A cg21475434 chr5:93447410 FAM172A 0.88 7.52 0.42 8.32e-13 Diabetic retinopathy; CESC cis rs6570726 0.791 rs7765687 chr6:145915100 A/C cg23711669 chr6:146136114 FBXO30 0.88 13.21 0.63 5.75e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg02398342 chr17:80708632 TBCD;FN3K 0.47 5.56 0.32 6.47e-8 Glycated hemoglobin levels; CESC cis rs17125944 0.505 rs77137752 chr14:53230496 G/T cg13660082 chr14:53194042 PSMC6 -0.67 -5.98 -0.34 7.29e-9 Alzheimer's disease (late onset); CESC trans rs9951602 0.512 rs12455591 chr18:76656028 A/G cg02800362 chr5:177631904 HNRNPAB 0.64 8.39 0.46 3.02e-15 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02386725 chr1:162467755 UHMK1 0.57 7.07 0.4 1.39e-11 Gut microbiome composition (summer); CESC cis rs9796 0.835 rs2927062 chr15:41302687 A/G cg18705301 chr15:41695430 NDUFAF1 -0.4 -5.92 -0.34 1e-8 Menopause (age at onset); CESC cis rs228437 1.000 rs4896083 chr6:134932535 G/A cg24504307 chr6:134963096 NA 0.55 5.93 0.34 9.31e-9 Melanoma; CESC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg12564285 chr5:131593104 PDLIM4 0.4 6.13 0.35 3.15e-9 Breast cancer; CESC cis rs6456156 0.528 rs6936261 chr6:167469676 A/C cg07741184 chr6:167504864 NA 0.37 6.36 0.36 8.95e-10 Primary biliary cholangitis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg07520141 chr5:10564205 ANKRD33B -0.45 -6.1 -0.35 3.77e-9 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02569219 chr17:2266849 SGSM2 0.47 6.34 0.36 9.84e-10 Fibrinogen levels; CESC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg23803603 chr1:2058230 PRKCZ -0.37 -6.68 -0.38 1.43e-10 Height; CESC cis rs116095464 0.558 rs6874745 chr5:264527 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.49 0.32 9.44e-8 Breast cancer; CESC cis rs11971779 0.938 rs11981688 chr7:139088895 A/G cg07862535 chr7:139043722 LUC7L2 0.56 5.74 0.33 2.63e-8 Diisocyanate-induced asthma; CESC cis rs6991838 0.557 rs67685675 chr8:66486606 T/C cg13398993 chr8:66546079 ARMC1 -0.46 -5.54 -0.32 7.22e-8 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08689931 chr7:86781758 DMTF1 0.55 6.52 0.37 3.52e-10 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs9911490 chr17:29073013 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6831352 0.918 rs13133633 chr4:100058697 C/G cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg19163074 chr7:65112434 INTS4L2 0.45 5.18 0.3 4.32e-7 Aortic root size; CESC cis rs8072100 0.967 rs4338849 chr17:45512483 A/G cg08085267 chr17:45401833 C17orf57 -0.52 -7.09 -0.4 1.24e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1790761 0.505 rs4320958 chr11:67310334 G/A cg24690094 chr11:67383802 NA -0.32 -5.44 -0.32 1.21e-7 Mean corpuscular volume; CESC cis rs11122272 0.735 rs2572251 chr1:231514243 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs6690583 0.697 rs10782537 chr1:85484473 C/T cg11262906 chr1:85462892 MCOLN2 -0.55 -6.76 -0.38 8.92e-11 Serum sulfate level; CESC cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg02574844 chr11:5959923 NA 0.39 5.6 0.33 5.33e-8 DNA methylation (variation); CESC cis rs9611565 0.512 rs4822052 chr22:42193741 G/A cg06481639 chr22:41940642 POLR3H -0.63 -6.39 -0.37 7.46e-10 Vitiligo; CESC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg02896835 chr1:92012615 NA -0.53 -6.82 -0.39 6.14e-11 Breast cancer; CESC cis rs9399135 0.967 rs1041481 chr6:135335063 G/A cg24558204 chr6:135376177 HBS1L 0.53 7.22 0.41 5.63e-12 Red blood cell count; CESC cis rs9911578 1.000 rs2055779 chr17:57030561 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.2 0.68 5.84e-38 Intelligence (multi-trait analysis); CESC cis rs60154123 0.730 rs588197 chr1:210463515 A/T cg25204440 chr1:209979598 IRF6 0.45 5.12 0.3 5.88e-7 Coronary artery disease; CESC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.68 -0.33 3.54e-8 Total body bone mineral density; CESC cis rs6088580 0.634 rs4911152 chr20:32955024 T/C cg24642439 chr20:33292090 TP53INP2 -0.51 -6.75 -0.38 9.39e-11 Glomerular filtration rate (creatinine); CESC cis rs9858542 0.953 rs11922013 chr3:49458355 G/C cg03060546 chr3:49711283 APEH -0.55 -6.21 -0.36 2.08e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs875971 0.706 rs1643374 chr7:65872682 T/A cg26939375 chr7:64535504 NA 0.63 8.24 0.45 8.21e-15 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08321272 chr4:41992621 SLC30A9 -0.63 -7.39 -0.41 1.87e-12 Gut microbiome composition (summer); CESC cis rs2739330 0.892 rs5751776 chr22:24266954 A/C cg12419862 chr22:24373484 LOC391322 -0.82 -12.09 -0.6 4.16e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs11098499 0.954 rs11729521 chr4:120416788 T/C cg09307838 chr4:120376055 NA 0.93 13.06 0.63 2.03e-30 Corneal astigmatism; CESC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg24818145 chr4:99064322 C4orf37 0.4 5.04 0.3 8.69e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12545109 0.800 rs2609978 chr8:57394467 T/C cg09654669 chr8:57350985 NA -0.54 -6.56 -0.37 2.86e-10 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00551736 chr7:151573592 PRKAG2 -0.47 -6.11 -0.35 3.59e-9 Fibrinogen levels; CESC cis rs1008375 1.000 rs6849704 chr4:17652031 G/C cg02297831 chr4:17616191 MED28 0.53 6.71 0.38 1.2e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10088262 0.629 rs7015861 chr8:124795613 C/T cg15047889 chr8:124780837 FAM91A1 -0.51 -6.48 -0.37 4.44e-10 Pancreatic cancer; CESC cis rs10905065 0.930 rs10795485 chr10:5755047 T/C cg11519256 chr10:5708881 ASB13 0.44 5.85 0.34 1.43e-8 Menopause (age at onset); CESC cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg11764359 chr7:65958608 NA 0.78 11.28 0.57 2.25e-24 Aortic root size; CESC cis rs9314323 0.535 rs1055479 chr8:26240646 A/G cg11498726 chr8:26250323 BNIP3L -0.41 -6.15 -0.35 2.9e-9 Red cell distribution width; CESC cis rs4148883 0.675 rs11724783 chr4:100099688 C/A cg12011299 chr4:100065546 ADH4 0.66 9.72 0.51 2.67e-19 Alcohol dependence; CESC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.69 6.11 0.35 3.54e-9 Platelet count; CESC cis rs2439831 1.000 rs689781 chr15:43792097 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.58 0.54 4.72e-22 Lung cancer in ever smokers; CESC cis rs11048434 0.698 rs1805784 chr12:9065172 G/T cg23795048 chr12:9217529 LOC144571 0.36 5.68 0.33 3.46e-8 Sjögren's syndrome; CESC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7662987 0.517 rs2851265 chr4:100029684 A/G cg13256891 chr4:100009986 ADH5 0.73 7.78 0.43 1.66e-13 Smoking initiation; CESC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg26343298 chr8:95960752 TP53INP1 0.32 5.25 0.31 3.15e-7 Type 2 diabetes; CESC cis rs78456975 0.527 rs7590743 chr2:1575048 A/G cg12573674 chr2:1569213 NA -0.46 -5.2 -0.3 3.96e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs2985684 0.947 rs1952013 chr14:50087357 C/G cg02151108 chr14:50098012 C14orf104 -0.47 -6.09 -0.35 3.92e-9 Carotid intima media thickness; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12121965 chr21:46293563 PTTG1IP -0.42 -6.52 -0.37 3.49e-10 Gambling; CESC cis rs9911578 1.000 rs9898626 chr17:56698219 C/G cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC cis rs7772486 0.738 rs75288066 chr6:146319386 C/A cg23711669 chr6:146136114 FBXO30 0.81 11.43 0.57 7.46e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs9815354 1.000 rs1717017 chr3:41915616 A/C cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7077164 1.000 rs1227764 chr10:71583223 G/A cg07630274 chr10:71583235 COL13A1 -0.39 -7.33 -0.41 2.8e-12 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg11764359 chr7:65958608 NA 0.96 15.26 0.68 3.66e-38 Aortic root size; CESC cis rs3815700 1.000 rs10406750 chr19:33097144 C/T cg02997394 chr19:33096574 ANKRD27 0.71 7.25 0.41 4.59e-12 Eosinophilic esophagitis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15120146 chr6:42897303 CNPY3 -0.43 -6.21 -0.36 1.98e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1729951 0.545 rs1097288 chr3:136693721 C/T cg04103450 chr3:136751342 NA 0.4 5.31 0.31 2.32e-7 Neuroticism; CESC trans rs208520 1.000 rs208521 chr6:66953625 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -9.42 -0.5 2.36e-18 Exhaled nitric oxide output; CESC cis rs4268898 0.697 rs10445892 chr2:24406958 T/C cg06627628 chr2:24431161 ITSN2 0.54 7.22 0.41 5.5e-12 Asthma; CESC trans rs561341 1.000 rs693116 chr17:30246124 C/T cg20587970 chr11:113659929 NA -1.43 -17.6 -0.73 1.89e-46 Hip circumference adjusted for BMI; CESC cis rs34375054 0.735 rs34961756 chr12:125628598 C/T cg25124228 chr12:125621409 AACS -0.61 -8.43 -0.46 2.2e-15 Post bronchodilator FEV1/FVC ratio; CESC cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg05347473 chr6:146136440 FBXO30 -0.56 -7.23 -0.41 5.1e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs523522 0.962 rs2235218 chr12:120888619 A/C cg27279351 chr12:120934652 DYNLL1 0.66 8.19 0.45 1.09e-14 High light scatter reticulocyte count; CESC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg22920501 chr2:26401640 FAM59B -0.67 -8.09 -0.44 2.22e-14 Gut microbiome composition (summer); CESC cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg03060546 chr3:49711283 APEH 0.47 5.68 0.33 3.6e-8 Parkinson's disease; CESC cis rs6835098 1.000 rs6835098 chr4:174089238 T/C cg08422745 chr4:174089978 GALNT7 -0.82 -12.01 -0.59 7.93e-27 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs10838687 0.736 rs7933246 chr11:47262648 G/C cg25783544 chr11:47291846 MADD 0.57 6.63 0.38 1.91e-10 Proinsulin levels; CESC cis rs7312933 0.966 rs7977365 chr12:42513127 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.44 5.75 0.33 2.48e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6690583 0.623 rs1371140 chr1:85455362 A/C cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs2651899 0.902 rs2742673 chr1:3080019 A/C cg22674798 chr1:3096360 PRDM16 -0.39 -7.6 -0.42 5.07e-13 Migraine; CESC cis rs1670533 0.872 rs13108222 chr4:1054256 C/A cg27284194 chr4:1044797 NA 0.46 5.85 0.34 1.42e-8 Recombination rate (females); CESC cis rs8114671 0.647 rs1124511 chr20:33736697 A/C cg24642439 chr20:33292090 TP53INP2 0.5 6.43 0.37 5.94e-10 Height; CESC cis rs854765 0.604 rs12948749 chr17:17949802 G/A cg04398451 chr17:18023971 MYO15A 0.7 10.14 0.53 1.27e-20 Total body bone mineral density; CESC cis rs4077515 1.000 rs4077515 chr9:139266496 C/T cg14169450 chr9:139327907 INPP5E 0.36 5.24 0.31 3.35e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs3806843 0.966 rs10060640 chr5:140211226 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.26 -0.31 3.03e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7223966 1.000 rs72848797 chr17:61934664 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.47 -5.35 -0.31 1.9e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7107174 1.000 rs10793302 chr11:78040961 C/T cg03754400 chr11:77348600 CLNS1A 0.43 5.06 0.3 7.72e-7 Testicular germ cell tumor; CESC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg03188948 chr7:1209495 NA 0.72 6.93 0.39 3.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.649 rs202657 chr22:41844786 G/T cg06481639 chr22:41940642 POLR3H 0.58 5.81 0.34 1.75e-8 Vitiligo; CESC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg24562669 chr7:97807699 LMTK2 0.47 6.73 0.38 1.07e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02632015 chr17:19551762 ALDH3A2 0.56 6.32 0.36 1.1e-9 Gut microbiome composition (summer); CESC cis rs826838 1.000 rs11168505 chr12:38939057 A/T cg13010199 chr12:38710504 ALG10B -0.57 -8.21 -0.45 9.74e-15 Heart rate; CESC cis rs68170813 0.559 rs1002935 chr7:106832361 G/A cg02696742 chr7:106810147 HBP1 -0.55 -5.3 -0.31 2.42e-7 Coronary artery disease; CESC cis rs938554 0.657 rs9994216 chr4:9984541 G/T cg11266682 chr4:10021025 SLC2A9 0.39 5.85 0.34 1.45e-8 Blood metabolite levels; CESC cis rs9581857 0.685 rs9581856 chr13:28025615 G/C cg01674679 chr13:27998804 GTF3A -0.67 -5.29 -0.31 2.58e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs34779708 0.931 rs34954932 chr10:35410807 G/T cg04310649 chr10:35416472 CREM -0.53 -6.54 -0.37 3.07e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs3820928 0.874 rs55748731 chr2:227818629 C/A cg11843606 chr2:227700838 RHBDD1 -0.41 -5.5 -0.32 9.06e-8 Pulmonary function; CESC cis rs2204008 0.694 rs1672436 chr12:38132547 G/T cg26384229 chr12:38710491 ALG10B -0.44 -5.99 -0.35 6.87e-9 Bladder cancer; CESC trans rs11088226 0.681 rs2833912 chr21:33949822 G/A cg09050820 chr6:167586206 TCP10L2 0.96 10.31 0.54 3.58e-21 Gastritis; CESC cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg02297831 chr4:17616191 MED28 -0.58 -6.83 -0.39 5.83e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7219021 0.705 rs962273 chr17:46978353 T/C cg16584676 chr17:46985605 UBE2Z 0.66 8.32 0.46 4.68e-15 Schizophrenia or bipolar disorder; CESC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.44 -5.99 -0.35 6.8e-9 Lymphocyte counts; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26685501 chr1:38019921 SNIP1 -0.46 -6.7 -0.38 1.27e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg19046167 chr17:80928561 B3GNTL1 0.41 5.48 0.32 9.72e-8 Breast cancer; CESC cis rs17401966 0.898 rs11582123 chr1:10303942 A/T cg15208524 chr1:10270712 KIF1B 0.41 5.34 0.31 1.95e-7 Hepatocellular carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03274117 chr8:56686508 TMEM68;TGS1 -0.57 -6.95 -0.39 2.87e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12733907 chr3:57261991 APPL1 0.54 6.45 0.37 5.4e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg00166722 chr3:10149974 C3orf24 0.48 5.98 0.34 7.06e-9 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00762468 chr16:103568 POLR3K;SNRNP25 0.6 7.24 0.41 4.77e-12 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04653776 chr20:32399093 CHMP4B -0.47 -6.46 -0.37 5.01e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg18016565 chr1:150552671 MCL1 0.33 5.13 0.3 5.67e-7 Tonsillectomy; CESC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg04055107 chr11:65626734 MUS81;CFL1 -0.44 -5.04 -0.3 8.66e-7 Breast cancer; CESC cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg19193384 chr17:30244184 NA -0.68 -6.43 -0.37 5.9e-10 Hip circumference adjusted for BMI; CESC cis rs1005277 0.540 rs4934907 chr10:38015230 A/C cg25427524 chr10:38739819 LOC399744 -0.64 -9.43 -0.5 2.21e-18 Extrinsic epigenetic age acceleration; CESC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg17178900 chr1:205818956 PM20D1 -0.39 -5.32 -0.31 2.2e-7 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs2708240 1.000 rs2538991 chr7:147579619 A/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.36 -6.05 -0.35 4.82e-9 QT interval (drug interaction); CESC cis rs977987 0.843 rs12443834 chr16:75438469 C/T cg03315344 chr16:75512273 CHST6 0.41 5.86 0.34 1.35e-8 Dupuytren's disease; CESC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs67311347 0.822 rs9826847 chr3:40345312 A/T cg24209194 chr3:40518798 ZNF619 0.42 5.23 0.31 3.41e-7 Renal cell carcinoma; CESC cis rs9443645 0.527 rs10943595 chr6:79575291 C/G cg05283184 chr6:79620031 NA -0.36 -5.1 -0.3 6.62e-7 Intelligence (multi-trait analysis); CESC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg06484146 chr7:12443880 VWDE -0.78 -9.1 -0.49 2.28e-17 Coronary artery disease; CESC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.45 -5.1 -0.3 6.46e-7 Breast cancer; CESC cis rs7208859 0.673 rs56146117 chr17:29153325 C/T cg19761014 chr17:28927070 LRRC37B2 0.74 6.03 0.35 5.43e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9815354 0.812 rs60659106 chr3:41949569 G/C cg03022575 chr3:42003672 ULK4 0.71 6.45 0.37 5.42e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg12463550 chr7:65579703 CRCP 0.56 7.06 0.4 1.47e-11 Aortic root size; CESC cis rs8141529 0.748 rs2064261 chr22:29287730 C/T cg15103426 chr22:29168792 CCDC117 0.6 7.65 0.43 3.63e-13 Lymphocyte counts; CESC cis rs7084402 0.967 rs2577392 chr10:60329183 A/G cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs901683 1.000 rs9422651 chr10:46047456 C/T cg16031567 chr10:46195673 NA -0.74 -5.03 -0.3 8.96e-7 Red blood cell traits;Mean corpuscular volume; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00469508 chr10:112327249 SMC3 -0.49 -6.45 -0.37 5.23e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04867738 chr17:42298359 UBTF 0.55 6.05 0.35 4.81e-9 Gut microbiome composition (summer); CESC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg04317338 chr11:64019027 PLCB3 0.87 9.06 0.49 3.04e-17 Mean platelet volume; CESC cis rs11252926 1.000 rs11252926 chr10:566379 C/T cg18196295 chr10:418757 DIP2C -0.51 -6.01 -0.35 6.01e-9 Psychosis in Alzheimer's disease; CESC cis rs7216064 1.000 rs6504548 chr17:65886048 T/C cg07042672 chr17:66097459 LOC651250 -0.63 -7.44 -0.42 1.38e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.65 0.64 1.68e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4704187 0.687 rs9654426 chr5:74466737 C/T cg03227963 chr5:74354835 NA 0.29 5.28 0.31 2.67e-7 Response to amphetamines; CESC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg06505273 chr16:24850292 NA -0.47 -5.36 -0.31 1.79e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1538970 0.924 rs1007858 chr1:45912005 C/T cg03146154 chr1:46216737 IPP 0.46 5.34 0.31 1.97e-7 Platelet count; CESC trans rs11039798 0.687 rs11499938 chr11:48957297 G/A cg15704280 chr7:45808275 SEPT13 0.71 6.63 0.38 1.91e-10 Axial length; CESC cis rs2239547 0.522 rs6792578 chr3:53004604 G/A cg11645453 chr3:52864694 ITIH4 0.33 5.49 0.32 9.5e-8 Schizophrenia; CESC trans rs208520 0.802 rs208496 chr6:66930786 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.86 -9.98 -0.52 4.07e-20 Exhaled nitric oxide output; CESC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg21782813 chr7:2030301 MAD1L1 0.5 7.26 0.41 4.36e-12 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26591221 chr16:88942335 CBFA2T3 -0.58 -6.84 -0.39 5.36e-11 Gut microbiome composition (summer); CESC cis rs36051895 0.659 rs72701605 chr9:5062056 G/A cg02405213 chr9:5042618 JAK2 -0.5 -6.13 -0.35 3.19e-9 Pediatric autoimmune diseases; CESC trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg15556689 chr8:8085844 FLJ10661 0.52 6.45 0.37 5.2400000000000005e-10 Triglycerides; CESC cis rs6963495 0.818 rs6961863 chr7:105180953 C/T cg02135003 chr7:105160482 PUS7 -0.42 -5.42 -0.32 1.34e-7 Bipolar disorder (body mass index interaction); CESC trans rs9858542 1.000 rs1131095 chr3:49714225 T/C cg21659725 chr3:3221576 CRBN -0.55 -6.72 -0.38 1.11e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs11997175 0.625 rs7460540 chr8:33597907 A/G ch.8.33884649F chr8:33765107 NA 0.51 6.29 0.36 1.34e-9 Body mass index; CESC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg04756594 chr16:24857601 SLC5A11 0.49 5.63 0.33 4.68e-8 Intelligence (multi-trait analysis); CESC cis rs7481584 0.624 rs440130 chr11:3051476 A/G cg08508325 chr11:3079039 CARS 0.29 5.17 0.3 4.6e-7 Calcium levels; CESC cis rs9457247 1.000 rs397713 chr6:167386714 G/A cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC cis rs72781680 0.821 rs17038360 chr2:24095798 A/G cg08917208 chr2:24149416 ATAD2B 0.58 5.81 0.34 1.82e-8 Lymphocyte counts; CESC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg22903471 chr2:27725779 GCKR -0.47 -6.58 -0.37 2.51e-10 Total body bone mineral density; CESC cis rs4330281 0.765 rs13079096 chr3:17795076 T/A cg20981856 chr3:17787350 NA 0.36 5.21 0.3 3.79e-7 Schizophrenia; CESC cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg14345882 chr6:26364793 BTN3A2 0.41 5.25 0.31 3.16e-7 Intelligence (multi-trait analysis); CESC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg08736216 chr1:53307985 ZYG11A 0.43 7.16 0.4 7.72e-12 Monocyte count; CESC cis rs870825 0.549 rs7656993 chr4:185635159 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.89 0.39 3.95e-11 Blood protein levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04873026 chr21:30365177 RNF160 -0.47 -6.47 -0.37 4.76e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs861020 0.630 rs9308411 chr1:210005713 C/T cg05527609 chr1:210001259 C1orf107 0.72 9.81 0.52 1.35e-19 Orofacial clefts; CESC cis rs7191439 0.858 rs8044367 chr16:88783374 A/G cg02389323 chr16:88786976 FAM38A 0.85 6.44 0.37 5.49e-10 Plateletcrit; CESC cis rs4253772 0.591 rs6519993 chr22:46656479 A/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.48 5.08 0.3 7.09e-7 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08928321 chr10:70748447 KIAA1279 -0.61 -7.62 -0.42 4.61e-13 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs138705 chr22:39133803 C/T cg14440974 chr22:39074834 NA -0.39 -5.42 -0.32 1.36e-7 Menopause (age at onset); CESC trans rs35110281 0.720 rs162400 chr21:44950305 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 7.35 0.41 2.5e-12 Mean corpuscular volume; CESC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.85 14.3 0.66 9.42e-35 Menarche (age at onset); CESC cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg06544989 chr22:39130855 UNC84B 0.51 8.92 0.48 7.61e-17 Menopause (age at onset); CESC cis rs2840044 0.517 rs2124247 chr17:33885468 G/A cg05299278 chr17:33885742 SLFN14 0.42 5.95 0.34 8.56e-9 Response to radiotherapy in cancer (late toxicity); CESC cis rs2637266 1.000 rs34483246 chr10:78342790 G/A cg18941641 chr10:78392320 NA 0.41 7.78 0.43 1.65e-13 Pulmonary function; CESC cis rs6076065 0.925 rs2281430 chr20:23399314 T/C cg12062639 chr20:23401060 NAPB 0.41 5.08 0.3 7.25e-7 Facial morphology (factor 15, philtrum width); CESC cis rs888194 0.677 rs2075431 chr12:109874621 C/T cg19025524 chr12:109796872 NA -0.41 -6.14 -0.35 3.08e-9 Neuroticism; CESC cis rs72634258 0.786 rs9434992 chr1:8179392 G/T cg00042356 chr1:8021962 PARK7 0.5 5.43 0.32 1.29e-7 Inflammatory bowel disease; CESC cis rs6691722 0.506 rs12030365 chr1:24739220 T/A cg02336364 chr1:24764700 NIPAL3 0.31 6.14 0.35 2.99e-9 Response to interferon beta in multiple sclerosis; CESC cis rs6547741 1.000 rs1080060 chr2:27768808 T/A cg21248554 chr2:27665150 KRTCAP3 0.25 5.21 0.31 3.71e-7 Oral cavity cancer; CESC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg06481639 chr22:41940642 POLR3H -0.63 -6.57 -0.37 2.63e-10 Vitiligo; CESC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg23172400 chr8:95962367 TP53INP1 -0.46 -9.8 -0.52 1.55e-19 Type 2 diabetes; CESC cis rs5753618 0.561 rs2040533 chr22:31679110 G/C cg13145458 chr22:31556086 RNF185 0.48 5.38 0.31 1.61e-7 Colorectal cancer; CESC cis rs10504073 0.565 rs35282337 chr8:49920994 G/A cg00325661 chr8:49890786 NA 0.53 7.95 0.44 5.42e-14 Blood metabolite ratios; CESC cis rs9640161 0.789 rs4554381 chr7:150025567 G/A cg13722127 chr7:150037890 RARRES2 0.34 5.21 0.3 3.76e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs11098499 0.662 rs13108589 chr4:120268102 G/C cg09307838 chr4:120376055 NA 0.81 10.78 0.55 1.07e-22 Corneal astigmatism; CESC cis rs7619708 1 rs7619708 chr3:195810187 T/C cg12923728 chr3:195709715 SDHAP1 0.58 5.99 0.35 6.77e-9 Red cell distribution width; CESC cis rs7927771 0.507 rs10838754 chr11:47758532 A/C cg18512352 chr11:47633146 NA 0.36 5.58 0.32 6.08e-8 Subjective well-being; CESC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg12419862 chr22:24373484 LOC391322 -0.66 -9.06 -0.49 3.02e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4076764 0.830 rs10917770 chr1:163442214 G/C cg24596788 chr1:163392923 NA -0.47 -6.94 -0.39 3.08e-11 Motion sickness; CESC cis rs7809950 0.954 rs3779494 chr7:107250355 G/A cg23024343 chr7:107201750 COG5 0.45 6.26 0.36 1.58e-9 Coronary artery disease; CESC trans rs7618501 0.699 rs2681780 chr3:49897830 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.48 6.64 0.38 1.81e-10 Intelligence (multi-trait analysis); CESC cis rs962856 1.000 rs962856 chr2:67593803 C/T cg09028215 chr2:67624308 ETAA1 -0.41 -5.43 -0.32 1.3e-7 Pancreatic cancer; CESC cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -7.26 -0.41 4.25e-12 Personality dimensions; CESC cis rs425277 1.000 rs12401379 chr1:2058580 G/C cg24578937 chr1:2090814 PRKCZ 0.54 9.0 0.48 4.48e-17 Height; CESC cis rs17253792 0.822 rs74051609 chr14:56171132 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.64 5.08 0.3 7.04e-7 Putamen volume; CESC cis rs9513593 1.000 rs7331894 chr13:99852952 C/T cg21788972 chr13:99853209 UBAC2 0.61 6.81 0.39 6.58e-11 Psoriasis; CESC cis rs79349575 0.756 rs2643361 chr17:46977462 T/G cg16584676 chr17:46985605 UBE2Z 0.53 6.58 0.37 2.57e-10 Type 2 diabetes; CESC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg18758796 chr5:131593413 PDLIM4 0.38 5.17 0.3 4.59e-7 Breast cancer; CESC cis rs2230307 0.536 rs490669 chr1:100484430 C/T cg24955406 chr1:100503596 HIAT1 0.54 5.44 0.32 1.19e-7 Carotid intima media thickness; CESC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg17747265 chr1:1875780 NA -0.58 -9.43 -0.5 2.13e-18 Body mass index; CESC trans rs17685 0.712 rs6976236 chr7:75741087 G/T cg19862616 chr7:65841803 NCRNA00174 0.83 11.95 0.59 1.29e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs6693567 0.565 rs471738 chr1:150276429 G/A cg09579323 chr1:150459698 TARS2 -0.47 -6.06 -0.35 4.7e-9 Migraine; CESC cis rs1950626 0.671 rs34675695 chr14:101447913 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.81 10.41 0.54 1.64e-21 Pelvic organ prolapse (moderate/severe); CESC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10436540 chr17:4047319 ZZEF1;CYB5D2 -0.43 -6.14 -0.35 3.06e-9 Gambling; CESC cis rs4629180 0.675 rs10195061 chr2:102093974 T/G cg04415270 chr2:102091202 RFX8 -0.32 -5.46 -0.32 1.09e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs2262909 0.566 rs10419058 chr19:22309972 A/C cg07498013 chr19:22123504 NA -0.32 -5.09 -0.3 6.66e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs938554 0.577 rs7683856 chr4:10000947 A/G cg11266682 chr4:10021025 SLC2A9 0.46 6.2 0.36 2.11e-9 Blood metabolite levels; CESC cis rs258892 0.947 rs34955 chr5:72203628 T/C cg21869765 chr5:72125136 TNPO1 0.44 5.58 0.32 6e-8 Small cell lung carcinoma; CESC cis rs9486719 1.000 rs4262195 chr6:96929475 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.45e-15 Migraine;Coronary artery disease; CESC cis rs4319547 0.794 rs61954972 chr12:123074167 T/G cg23029597 chr12:123009494 RSRC2 -0.49 -5.41 -0.32 1.41e-7 Body mass index; CESC cis rs6831352 0.918 rs2213035 chr4:100064233 G/A cg13256891 chr4:100009986 ADH5 -0.73 -7.79 -0.43 1.52e-13 Alcohol dependence; CESC cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg16339924 chr4:17578868 LAP3 0.67 8.27 0.45 6.7e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs765787 0.530 rs11070445 chr15:45513163 T/A cg24006582 chr15:45444508 DUOX1 0.54 6.54 0.37 3.12e-10 Uric acid levels; CESC cis rs2742234 0.541 rs7073849 chr10:43740474 G/C cg07801480 chr10:43725741 RASGEF1A -0.41 -5.21 -0.3 3.75e-7 Hirschsprung disease; CESC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg10792982 chr14:105748885 BRF1 0.41 5.26 0.31 2.96e-7 Mean platelet volume;Platelet distribution width; CESC cis rs4332037 0.539 rs868754 chr7:2033780 G/C cg23422044 chr7:1970798 MAD1L1 -0.49 -5.07 -0.3 7.48e-7 Bipolar disorder; CESC cis rs793571 0.502 rs411007 chr15:59078502 G/C cg05156742 chr15:59063176 FAM63B 0.78 11.12 0.56 8e-24 Schizophrenia; CESC cis rs12950390 0.853 rs56363619 chr17:45854621 T/C cg00777063 chr17:45855553 NA -0.39 -5.78 -0.33 2.05e-8 IgG glycosylation; CESC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg04267008 chr7:1944627 MAD1L1 -0.63 -8.2 -0.45 1.05e-14 Bipolar disorder and schizophrenia; CESC cis rs8070740 0.898 rs4578712 chr17:5324431 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.35 0.36 9.3e-10 Menopause (age at onset); CESC cis rs7649275 0.882 rs7373113 chr3:53790054 A/C cg21503701 chr3:53781065 CACNA1D -0.4 -5.03 -0.3 8.95e-7 Trans fatty acid levels; CESC cis rs662064 0.692 rs12129512 chr1:10572967 G/T cg20482658 chr1:10539492 PEX14 0.33 5.61 0.33 5.13e-8 Asthma; CESC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs2354432 0.607 rs6677679 chr1:146803630 C/T cg25205988 chr1:146714368 CHD1L -1.03 -9.0 -0.48 4.56e-17 Mitochondrial DNA levels; CESC cis rs7246657 0.882 rs6508719 chr19:37877419 A/G cg23950597 chr19:37808831 NA -0.55 -6.05 -0.35 4.84e-9 Coronary artery calcification; CESC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg18099408 chr3:52552593 STAB1 -0.36 -6.09 -0.35 4.06e-9 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03920172 chr3:170075494 SKIL -0.54 -6.72 -0.38 1.11e-10 Gut microbiome composition (summer); CESC cis rs9494142 0.592 rs1547247 chr6:135390836 C/T cg24558204 chr6:135376177 HBS1L 0.59 7.0 0.39 2.13e-11 Lymphocyte counts;Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg04944784 chr2:26401820 FAM59B -0.68 -7.71 -0.43 2.47e-13 Gut microbiome composition (summer); CESC cis rs4654899 0.772 rs10916892 chr1:21201325 A/G cg05370193 chr1:21551575 ECE1 0.36 5.2 0.3 4e-7 Superior frontal gyrus grey matter volume; CESC cis rs9828933 0.577 rs704374 chr3:63865947 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.9 8.91 0.48 8.43e-17 Type 2 diabetes; CESC cis rs2204008 0.805 rs11522896 chr12:38234427 T/C cg13010199 chr12:38710504 ALG10B 0.52 6.43 0.37 5.91e-10 Bladder cancer; CESC cis rs9300255 0.566 rs1716169 chr12:123716930 A/T cg00376283 chr12:123451042 ABCB9 0.6 6.2 0.36 2.1e-9 Neutrophil percentage of white cells; CESC cis rs9611565 0.694 rs202665 chr22:41814401 A/G cg06481639 chr22:41940642 POLR3H 0.61 6.41 0.37 6.55e-10 Vitiligo; CESC cis rs6866344 0.697 rs56159071 chr5:178127246 T/A cg10224037 chr5:178157518 ZNF354A 0.67 7.37 0.41 2.13e-12 Neutrophil percentage of white cells; CESC cis rs3749237 0.636 rs1568662 chr3:49521263 A/G cg07636037 chr3:49044803 WDR6 0.6 8.72 0.47 3.04e-16 Resting heart rate; CESC cis rs11077998 1.000 rs11077998 chr17:80483946 C/G cg10255544 chr17:80519551 FOXK2 -0.55 -8.93 -0.48 7.08e-17 Reticulocyte fraction of red cells; CESC trans rs10242455 0.702 rs6974831 chr7:99131605 A/G cg09045935 chr12:6379348 NA 0.91 7.48 0.42 1.07e-12 Blood metabolite levels; CESC cis rs9467711 0.524 rs13216484 chr6:26762087 C/T cg14345882 chr6:26364793 BTN3A2 0.64 5.81 0.34 1.8e-8 Autism spectrum disorder or schizophrenia; CESC cis rs9894429 0.646 rs12948797 chr17:79617384 G/A cg21984481 chr17:79567631 NPLOC4 -0.33 -5.08 -0.3 7.26e-7 Eye color traits; CESC cis rs1499972 0.618 rs62264769 chr3:117643464 A/T cg07612923 chr3:117604196 NA 0.69 6.32 0.36 1.12e-9 Schizophrenia; CESC cis rs116161686 0.500 rs76610459 chr1:210050756 T/G cg23283495 chr1:209979779 IRF6 0.48 5.28 0.31 2.71e-7 Coronary artery disease; CESC cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg20701182 chr2:24300061 SF3B14 0.93 10.41 0.54 1.73e-21 Lymphocyte counts; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg23522832 chr1:45769727 LOC400752 -0.49 -6.03 -0.35 5.48e-9 Gut microbiota (bacterial taxa); CESC cis rs10979 0.631 rs12530338 chr6:143872563 C/T cg25407410 chr6:143891975 LOC285740 -0.4 -5.38 -0.31 1.62e-7 Hypospadias; CESC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg25985355 chr7:65971099 NA 0.31 5.3 0.31 2.38e-7 Aortic root size; CESC cis rs7523050 0.643 rs34801874 chr1:109404382 C/T cg08274380 chr1:109419600 GPSM2 0.85 5.82 0.34 1.74e-8 Fat distribution (HIV); CESC cis rs1448094 0.845 rs17354637 chr12:86347752 A/G cg02569458 chr12:86230093 RASSF9 0.38 5.5 0.32 8.85e-8 Major depressive disorder; CESC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg12463550 chr7:65579703 CRCP 0.56 7.07 0.4 1.39e-11 Aortic root size; CESC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg07870213 chr5:140052090 DND1 0.63 7.17 0.4 7.55e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12347191 0.500 rs907579 chr9:100622723 G/T cg13688889 chr9:100608707 NA -0.89 -13.0 -0.62 3.11e-30 Orofacial clefts; CESC cis rs7017914 0.967 rs7001162 chr8:71587470 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.09 -0.3 6.93e-7 Bone mineral density; CESC cis rs6088580 0.609 rs6059845 chr20:33036500 G/A cg06115741 chr20:33292138 TP53INP2 0.46 5.99 0.35 6.73e-9 Glomerular filtration rate (creatinine); CESC cis rs7945705 0.967 rs56316046 chr11:8876598 G/T cg09997546 chr11:8931473 C11orf17;ST5 0.35 5.72 0.33 2.82e-8 Hemoglobin concentration; CESC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg22920501 chr2:26401640 FAM59B -0.84 -9.82 -0.52 1.26e-19 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs11208976 chr1:67434411 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.19 -0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg21782813 chr7:2030301 MAD1L1 0.42 5.89 0.34 1.2e-8 Bipolar disorder and schizophrenia; CESC cis rs9457247 1.000 rs408087 chr6:167398952 C/T cg23791538 chr6:167370224 RNASET2 -0.57 -8.06 -0.44 2.59e-14 Crohn's disease; CESC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg04166393 chr7:2884313 GNA12 -0.62 -8.3 -0.45 5.27e-15 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05287481 chr11:17249967 NA -0.58 -6.75 -0.38 9.37e-11 Gut microbiome composition (summer); CESC cis rs9902453 0.715 rs2628176 chr17:28139292 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -9.41 -0.5 2.5e-18 Coffee consumption (cups per day); CESC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg01763666 chr17:80159506 CCDC57 -0.37 -5.26 -0.31 2.95e-7 Life satisfaction; CESC cis rs4790312 0.748 rs4790873 chr17:1994966 G/T cg20777128 chr17:1945076 DPH1;OVCA2 -0.39 -5.13 -0.3 5.72e-7 Left atrial antero-posterior diameter; CESC cis rs637571 0.544 rs56239996 chr11:65730003 A/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.48 6.28 0.36 1.39e-9 Eosinophil percentage of white cells; CESC cis rs7829975 0.564 rs2976855 chr8:8301794 G/A cg06636001 chr8:8085503 FLJ10661 0.52 6.72 0.38 1.13e-10 Mood instability; CESC cis rs72627123 0.737 rs77361581 chr14:74465290 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.43 0.32 1.26e-7 Morning vs. evening chronotype; CESC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.66 -8.82 -0.48 1.54e-16 Prudent dietary pattern; CESC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg03806693 chr22:41940476 POLR3H -1.21 -15.69 -0.69 1.07e-39 Vitiligo; CESC cis rs561341 0.700 rs886223 chr17:30229877 G/T cg13647721 chr17:30228624 UTP6 0.81 10.17 0.53 1.01e-20 Hip circumference adjusted for BMI; CESC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg08736216 chr1:53307985 ZYG11A -0.39 -6.47 -0.37 4.79e-10 Monocyte count; CESC cis rs9811920 0.541 rs1016914 chr3:99640121 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs9486719 1.000 rs2472889 chr6:96866803 T/G cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs35146811 0.883 rs4134903 chr7:99711040 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.48 6.01 0.35 6.15e-9 Coronary artery disease; CESC cis rs116095464 0.850 rs10055295 chr5:243749 G/A cg10591111 chr5:226296 SDHA -0.52 -6.38 -0.36 7.94e-10 Breast cancer; CESC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg06481639 chr22:41940642 POLR3H -0.61 -6.47 -0.37 4.81e-10 Vitiligo; CESC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg18099408 chr3:52552593 STAB1 -0.33 -5.45 -0.32 1.17e-7 Bipolar disorder; CESC cis rs10504229 0.679 rs72649120 chr8:58040308 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -6.85 -0.39 5e-11 Developmental language disorder (linguistic errors); CESC cis rs3733585 0.664 rs17185870 chr4:9958214 C/A cg02734326 chr4:10020555 SLC2A9 -0.43 -5.97 -0.34 7.58e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8027181 1.000 rs7164727 chr15:73093991 C/T cg25632853 chr15:73088954 NA 0.36 6.48 0.37 4.48e-10 Triglyceride levels; CESC cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg02873098 chr16:4524103 NMRAL1;HMOX2 0.37 5.39 0.31 1.55e-7 Schizophrenia; CESC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.25e-30 Prudent dietary pattern; CESC cis rs6456156 0.565 rs12529959 chr6:167469292 T/C cg07741184 chr6:167504864 NA 0.36 6.17 0.35 2.48e-9 Primary biliary cholangitis; CESC cis rs733175 0.855 rs10023068 chr4:10004832 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -5.24 -0.31 3.25e-7 Psychosis and Alzheimer's disease; CESC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.76 12.54 0.61 1.26e-28 Personality dimensions; CESC cis rs35110281 0.805 rs2838317 chr21:44991791 A/C cg04455712 chr21:45112962 RRP1B 0.37 5.5 0.32 9.16e-8 Mean corpuscular volume; CESC cis rs735396 0.770 rs2264782 chr12:121432603 C/T cg02403541 chr12:121454288 C12orf43 0.63 8.91 0.48 8.13e-17 N-glycan levels; CESC cis rs6430585 0.528 rs16832205 chr2:136684632 G/A cg07169764 chr2:136633963 MCM6 1.23 16.56 0.71 8.67e-43 Corneal structure; CESC cis rs10927875 0.632 rs6699394 chr1:16145143 C/A cg18973939 chr1:16164122 FLJ37453 0.37 5.52 0.32 8.17e-8 Dilated cardiomyopathy; CESC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs1322639 0.574 rs9689193 chr6:169588074 A/G cg03254818 chr6:169586852 NA 0.55 5.75 0.33 2.5e-8 Pulse pressure; CESC cis rs8062405 0.929 rs11150609 chr16:28870596 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs12142240 0.698 rs17361812 chr1:46814008 C/T cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs9611565 0.649 rs2413659 chr22:42164862 A/G cg06481639 chr22:41940642 POLR3H 0.48 5.49 0.32 9.4e-8 Vitiligo; CESC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg15556689 chr8:8085844 FLJ10661 0.45 5.78 0.33 2.11e-8 Mood instability; CESC cis rs35123781 1.000 rs35123781 chr5:139065180 A/G cg10513866 chr5:139070639 NA 0.39 5.76 0.33 2.36e-8 Schizophrenia; CESC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg08109568 chr15:31115862 NA 0.7 9.66 0.51 4.18e-19 Huntington's disease progression; CESC cis rs7771547 0.573 rs584418 chr6:36395437 G/A cg07856975 chr6:36356162 ETV7 0.36 5.38 0.31 1.67e-7 Platelet distribution width; CESC cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg01475377 chr6:109611718 NA 0.43 6.47 0.37 4.59e-10 Reticulocyte fraction of red cells; CESC cis rs2952156 0.920 rs2517957 chr17:37838716 G/A cg00129232 chr17:37814104 STARD3 -0.82 -12.14 -0.6 2.94e-27 Asthma; CESC cis rs225245 0.782 rs161183 chr17:33919475 G/C cg05299278 chr17:33885742 SLFN14 0.38 5.46 0.32 1.08e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs4808199 1.000 rs17288409 chr19:19504167 T/C cg03709012 chr19:19516395 GATAD2A 1.11 13.25 0.63 4.5e-31 Nonalcoholic fatty liver disease; CESC cis rs3733585 0.699 rs4621431 chr4:9947590 C/T cg02734326 chr4:10020555 SLC2A9 -0.44 -5.79 -0.33 2.03e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg13798912 chr7:905769 UNC84A -0.56 -5.53 -0.32 7.82e-8 Cerebrospinal P-tau181p levels; CESC cis rs8020095 0.571 rs17247792 chr14:67234457 G/A cg19548862 chr14:67692701 FAM71D -0.48 -5.84 -0.34 1.53e-8 Depression (quantitative trait); CESC trans rs877282 1.000 rs34257857 chr10:772993 C/A cg22713356 chr15:30763199 NA 1.12 11.31 0.57 1.87e-24 Uric acid levels; CESC trans rs724568 0.659 rs1430767 chr2:67928057 A/T cg19718508 chr5:176831858 F12 -0.45 -6.31 -0.36 1.2e-9 Major depressive disorder (broad); CESC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.69 6.12 0.35 3.41e-9 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13500430 chr11:2965905 NAP1L4 -0.54 -6.43 -0.37 5.83e-10 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs6445797 0.547 rs13094234 chr3:56582311 T/C cg13792233 chr3:56591045 CCDC66 0.4 5.31 0.31 2.28e-7 Gastritis; CESC cis rs6547741 1.000 rs4666009 chr2:27857992 T/A cg27432699 chr2:27873401 GPN1 0.51 7.23 0.41 5.02e-12 Oral cavity cancer; CESC trans rs17685 0.523 rs10246583 chr7:75746667 C/A cg19862616 chr7:65841803 NCRNA00174 0.83 11.92 0.59 1.67e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg10523679 chr1:76189770 ACADM 0.77 10.46 0.54 1.13e-21 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17560006 chr3:133969591 RYK 0.59 6.42 0.37 6.25e-10 Gut microbiome composition (summer); CESC cis rs778371 0.723 rs6739794 chr2:233576165 G/A cg08000102 chr2:233561755 GIGYF2 0.84 14.3 0.66 8.84e-35 Schizophrenia; CESC cis rs4642101 0.765 rs6791647 chr3:12826425 C/T cg05775895 chr3:12838266 CAND2 -0.41 -6.23 -0.36 1.84e-9 QRS complex (12-leadsum); CESC cis rs1707322 0.686 rs3014242 chr1:46087577 G/A cg06784218 chr1:46089804 CCDC17 -0.42 -7.32 -0.41 3.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs854765 0.583 rs10048206 chr17:17866897 A/G cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC cis rs11608355 0.515 rs1045582 chr12:109915727 G/T cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs10779751 0.887 rs6686835 chr1:11305316 G/A cg08854313 chr1:11322531 MTOR 0.84 11.96 0.59 1.16e-26 Body mass index; CESC cis rs75477785 0.590 rs17015076 chr1:209912593 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.8 5.24 0.31 3.31e-7 Cleft lip with or without cleft palate; CESC cis rs1707322 1.000 rs12124847 chr1:46380850 T/A cg06784218 chr1:46089804 CCDC17 0.35 5.96 0.34 7.85e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4253772 0.515 rs9615969 chr22:46773592 C/G cg24881330 chr22:46731750 TRMU 0.79 5.06 0.3 7.85e-7 LDL cholesterol;Cholesterol, total; CESC trans rs10772915 0.739 rs1799497 chr12:16399551 T/C cg01612449 chr11:66410467 RBM4 -0.38 -6.18 -0.35 2.42e-9 Visceral fat; CESC cis rs6089584 0.927 rs6089593 chr20:60572312 G/A cg06108461 chr20:60628389 TAF4 -0.81 -12.09 -0.6 4.39e-27 Body mass index; CESC cis rs11997175 0.766 rs4733178 chr8:33691899 A/T ch.8.33884649F chr8:33765107 NA 0.44 5.61 0.33 5.18e-8 Body mass index; CESC cis rs2204008 0.837 rs1842599 chr12:37986081 G/A cg26384229 chr12:38710491 ALG10B -0.53 -7.46 -0.42 1.26e-12 Bladder cancer; CESC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg25985355 chr7:65971099 NA 0.32 5.19 0.3 4.27e-7 Aortic root size; CESC trans rs12659622 0.703 rs17523929 chr5:15700585 A/G cg22457238 chr19:58570995 ZNF135 -0.55 -6.27 -0.36 1.47e-9 Obesity-related traits; CESC cis rs727505 0.821 rs73225498 chr7:124704197 C/T cg23710748 chr7:124431027 NA -0.38 -5.96 -0.34 8.16e-9 Lewy body disease; CESC cis rs959260 0.688 rs9894206 chr17:73360154 T/C cg20590849 chr17:73267439 MIF4GD -0.56 -6.17 -0.35 2.61e-9 Systemic lupus erythematosus; CESC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.6 5.27 0.31 2.83e-7 LDL cholesterol;Cholesterol, total; CESC trans rs3942852 0.806 rs4752808 chr11:48141252 G/A cg15704280 chr7:45808275 SEPT13 -0.64 -7.36 -0.41 2.32e-12 Acute lymphoblastic leukemia (childhood); CESC trans rs875971 1.000 rs778694 chr7:65871558 A/G cg26939375 chr7:64535504 NA 0.47 6.14 0.35 3.07e-9 Aortic root size; CESC cis rs3806843 0.712 rs2530244 chr5:140109155 A/G cg26395211 chr5:140044315 WDR55 0.46 6.16 0.35 2.62e-9 Depressive symptoms (multi-trait analysis); CESC trans rs629535 0.814 rs614050 chr8:70065642 G/A cg21567404 chr3:27674614 NA 0.88 10.34 0.54 2.74e-21 Dupuytren's disease; CESC cis rs752010 0.714 rs7513753 chr1:42079232 A/G cg06885757 chr1:42089581 HIVEP3 0.48 8.21 0.45 1.01e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs57506017 0.565 rs10278257 chr7:12253563 C/T cg23422036 chr7:12250390 TMEM106B 0.39 5.21 0.3 3.76e-7 Neuroticism; CESC cis rs11098499 0.754 rs1849457 chr4:120254355 A/G cg24375607 chr4:120327624 NA 0.41 5.04 0.3 8.48e-7 Corneal astigmatism; CESC cis rs1559088 0.600 rs7259117 chr19:33550113 G/T cg27124370 chr19:33622961 WDR88 0.54 7.48 0.42 1.08e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6831352 0.879 rs29001229 chr4:100046823 A/G cg13256891 chr4:100009986 ADH5 -0.76 -8.32 -0.46 4.63e-15 Alcohol dependence; CESC cis rs2839186 0.843 rs17182671 chr21:47696238 T/C cg10351095 chr21:47802916 PCNT -0.51 -6.98 -0.39 2.36e-11 Testicular germ cell tumor; CESC cis rs12042052 1.000 rs6696779 chr1:232920825 G/A cg00951395 chr1:232941775 KIAA1383 0.71 6.48 0.37 4.51e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg21782813 chr7:2030301 MAD1L1 0.49 7.0 0.39 2.14e-11 Bipolar disorder and schizophrenia; CESC cis rs6540559 0.546 rs74991018 chr1:210033790 T/G cg22029157 chr1:209979665 IRF6 0.72 7.16 0.4 8.04e-12 Cleft lip with or without cleft palate; CESC cis rs763121 0.925 rs17032 chr22:39130843 C/G cg21395723 chr22:39101663 GTPBP1 0.44 5.87 0.34 1.33e-8 Menopause (age at onset); CESC cis rs7666738 0.791 rs2081621 chr4:98926753 C/A cg05340658 chr4:99064831 C4orf37 0.82 12.23 0.6 1.45e-27 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17944940 chr17:73285520 SLC25A19 -0.5 -6.49 -0.37 4.1e-10 Fibrinogen levels; CESC trans rs4671386 0.901 rs2110401 chr2:60521970 T/C cg24386296 chr4:1723849 TMEM129;TACC3 0.51 6.39 0.37 7.28e-10 Acne (severe); CESC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg16132339 chr22:24313637 DDTL;DDT 0.37 5.64 0.33 4.37e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1559088 0.625 rs10411739 chr19:33616327 T/C cg03563238 chr19:33554763 RHPN2 -0.29 -5.27 -0.31 2.8e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg18252515 chr7:66147081 NA -0.43 -5.62 -0.33 4.86e-8 Aortic root size; CESC cis rs2380220 0.510 rs9387562 chr6:96057006 G/T cg15832292 chr6:96025679 MANEA 0.75 7.9 0.44 7.5e-14 Behavioural disinhibition (generation interaction); CESC cis rs7188697 0.922 rs37055 chr16:58560775 C/T cg21335942 chr16:58549945 SETD6 0.47 5.5 0.32 9.04e-8 QT interval; CESC cis rs17384381 0.953 rs12122816 chr1:85792384 C/T cg16011679 chr1:85725395 C1orf52 0.79 7.98 0.44 4.35e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg05347473 chr6:146136440 FBXO30 0.58 7.41 0.41 1.68e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs3780486 1.000 rs3780486 chr9:33139453 C/T cg04842962 chr6:43655489 MRPS18A 0.89 13.3 0.63 2.81e-31 IgG glycosylation; CESC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 21.72 0.8 8.88e-61 Prudent dietary pattern; CESC cis rs8062405 1.000 rs62037364 chr16:28868695 G/A cg08761264 chr16:28874980 SH2B1 -0.47 -5.89 -0.34 1.16e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03360920 chr6:159421029 RSPH3 0.69 8.62 0.47 6.13e-16 Gut microbiome composition (summer); CESC cis rs6547741 0.935 rs6749426 chr2:27847606 T/C cg21248554 chr2:27665150 KRTCAP3 0.25 5.23 0.31 3.37e-7 Oral cavity cancer; CESC trans rs61931739 0.500 rs7309421 chr12:34553795 C/T cg26384229 chr12:38710491 ALG10B 0.73 10.94 0.56 3.11e-23 Morning vs. evening chronotype; CESC cis rs34375054 0.687 rs35540170 chr12:125669122 C/G cg25124228 chr12:125621409 AACS -0.46 -5.2 -0.3 4.03e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs9894429 0.646 rs6565609 chr17:79592267 G/A cg13777783 chr17:79615861 NA -0.36 -6.11 -0.35 3.47e-9 Eye color traits; CESC cis rs9868809 0.505 rs11708786 chr3:48752654 C/T cg07636037 chr3:49044803 WDR6 -0.56 -5.09 -0.3 6.68e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs6968419 0.755 rs3807981 chr7:115896716 G/A cg02561103 chr7:115862891 TES -0.41 -5.35 -0.31 1.92e-7 Intraocular pressure; CESC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg06484146 chr7:12443880 VWDE -0.65 -9.3 -0.5 5.33e-18 Coronary artery disease; CESC cis rs7927771 0.524 rs10838769 chr11:47825333 A/G cg18512352 chr11:47633146 NA -0.36 -5.55 -0.32 6.84e-8 Subjective well-being; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05943731 chr12:123444284 ABCB9 0.51 7.2 0.4 6.07e-12 Fibrinogen levels; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg12783346 chr2:48117099 FBXO11 0.4 6.07 0.35 4.41e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg04455712 chr21:45112962 RRP1B 0.4 6.21 0.36 2.07e-9 Mean corpuscular volume; CESC cis rs2880765 0.835 rs7163958 chr15:86045215 G/A cg19183879 chr15:85880815 NA -0.25 -5.12 -0.3 5.84e-7 Coronary artery disease; CESC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg08355456 chr11:67383691 NA 0.33 5.18 0.3 4.36e-7 Mean corpuscular volume; CESC cis rs6867032 0.839 rs4314451 chr5:2001859 T/C cg26168224 chr5:2018326 NA -0.76 -11.49 -0.58 4.47e-25 Gut microbiome composition (winter); CESC cis rs1348850 0.914 rs1374437 chr2:178363423 T/C cg23306229 chr2:178417860 TTC30B 0.67 8.57 0.47 8.73e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2637266 0.678 rs846612 chr10:78550680 T/C cg18941641 chr10:78392320 NA 0.4 7.57 0.42 6.16e-13 Pulmonary function; CESC trans rs7944735 0.517 rs7952205 chr11:48199227 A/G cg15704280 chr7:45808275 SEPT13 0.7 6.76 0.38 8.86e-11 Intraocular pressure; CESC cis rs561341 0.941 rs501773 chr17:30314435 T/G cg00745463 chr17:30367425 LRRC37B -0.66 -6.7 -0.38 1.25e-10 Hip circumference adjusted for BMI; CESC trans rs11658311 0.850 rs11658846 chr17:17671486 G/C cg01883427 chr16:15242839 NA 0.55 6.22 0.36 1.96e-9 Obsessive-compulsive symptoms; CESC cis rs7267979 0.868 rs6138553 chr20:25239233 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 14.91 0.68 6.32e-37 Liver enzyme levels (alkaline phosphatase); CESC cis rs30380 1.000 rs246454 chr5:96123264 C/A cg16492584 chr5:96139282 ERAP1 -0.35 -5.36 -0.31 1.8e-7 Cerebrospinal fluid biomarker levels; CESC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg02353165 chr6:42928485 GNMT 0.89 15.21 0.68 5.68e-38 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7095944 0.614 rs10901817 chr10:126443404 A/T cg08799069 chr10:126477246 METTL10 -0.37 -5.28 -0.31 2.66e-7 Asthma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24571794 chr5:179564268 RASGEF1C 0.5 6.69 0.38 1.33e-10 Fibrinogen levels; CESC cis rs899997 1.000 rs9888691 chr15:79010046 T/C cg04896959 chr15:78267971 NA 0.39 5.84 0.34 1.53e-8 Coronary artery disease or large artery stroke; CESC cis rs929354 0.713 rs6946947 chr7:156948787 T/C cg05182265 chr7:156933206 UBE3C -0.5 -7.29 -0.41 3.49e-12 Body mass index; CESC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg02428538 chr16:24856791 SLC5A11 0.47 5.03 0.3 9.12e-7 Intelligence (multi-trait analysis); CESC trans rs5758511 0.773 rs62240999 chr22:42355563 C/G cg15080870 chr19:47770746 CCDC9 0.5 6.19 0.36 2.26e-9 Birth weight; CESC cis rs5769765 0.865 rs3788730 chr22:50244695 C/T cg02269571 chr22:50332266 NA 0.46 6.07 0.35 4.43e-9 Schizophrenia; CESC cis rs2599510 0.783 rs2568464 chr2:32848658 C/T cg02381751 chr2:32503542 YIPF4 -0.45 -5.77 -0.33 2.26e-8 Interleukin-18 levels; CESC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg22968622 chr17:43663579 NA 1.36 18.55 0.75 8.09e-50 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs258892 0.895 rs155429 chr5:72108080 G/A cg21869765 chr5:72125136 TNPO1 -0.44 -5.65 -0.33 4.05e-8 Small cell lung carcinoma; CESC cis rs6674176 0.561 rs12127226 chr1:44395309 C/T cg23954153 chr1:44402353 ARTN -0.35 -5.46 -0.32 1.08e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7267979 1.000 rs2500446 chr20:25339664 C/T cg08601574 chr20:25228251 PYGB -0.36 -5.05 -0.3 8.07e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs34779708 0.733 rs11597184 chr10:35397396 G/A cg03585969 chr10:35415529 CREM 0.76 9.99 0.52 3.71e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs61931739 0.534 rs73103090 chr12:34098801 C/T cg26384229 chr12:38710491 ALG10B 0.58 7.92 0.44 6.37e-14 Morning vs. evening chronotype; CESC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs6060717 0.610 rs2590965 chr20:34613120 C/T cg23207816 chr20:34252616 CPNE1;RBM12 -0.49 -6.26 -0.36 1.59e-9 Hip circumference adjusted for BMI; CESC cis rs6570726 0.967 rs373704 chr6:145860618 C/A cg05347473 chr6:146136440 FBXO30 0.43 5.76 0.33 2.38e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1843834 0.539 rs12694643 chr2:225446603 A/G cg12698349 chr2:225449008 CUL3 0.66 9.79 0.52 1.59e-19 IgE levels in asthmatics (D.p. specific); CESC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 11.78 0.59 4.76e-26 Alzheimer's disease; CESC cis rs6088580 0.634 rs4911418 chr20:32994257 G/A cg06115741 chr20:33292138 TP53INP2 -0.46 -5.98 -0.34 7.28e-9 Glomerular filtration rate (creatinine); CESC cis rs4242434 0.927 rs3735894 chr8:22454826 A/G cg03733263 chr8:22462867 KIAA1967 0.91 14.58 0.67 9.68e-36 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24690404 chr4:3507205 NA -0.59 -7.27 -0.41 4.09e-12 Gut microbiome composition (summer); CESC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg14773178 chr5:1868261 NA 0.34 6.28 0.36 1.4e-9 Cardiovascular disease risk factors; CESC cis rs8114671 0.551 rs4911162 chr20:33411425 G/C cg08999081 chr20:33150536 PIGU 0.39 5.45 0.32 1.18e-7 Height; CESC cis rs1023500 0.596 rs5758562 chr22:42448238 C/G cg15557168 chr22:42548783 NA -0.41 -5.32 -0.31 2.17e-7 Schizophrenia; CESC cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg23158103 chr7:148848205 ZNF398 -0.4 -6.43 -0.37 5.86e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg00339695 chr16:24857497 SLC5A11 -0.5 -6.62 -0.38 2.01e-10 Intelligence (multi-trait analysis); CESC cis rs1707322 0.964 rs1768802 chr1:46547868 A/G cg03146154 chr1:46216737 IPP -0.69 -9.04 -0.49 3.51e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.86 13.99 0.65 1.12e-33 Hip circumference adjusted for BMI; CESC cis rs6088580 0.608 rs2105109 chr20:32971932 A/G cg24642439 chr20:33292090 TP53INP2 -0.52 -6.9 -0.39 3.82e-11 Glomerular filtration rate (creatinine); CESC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg06634786 chr22:41940651 POLR3H 0.7 7.03 0.4 1.8e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs4474465 0.790 rs4544031 chr11:78265403 G/C cg27205649 chr11:78285834 NARS2 0.46 5.74 0.33 2.62e-8 Alzheimer's disease (survival time); CESC cis rs9611565 0.659 rs169361 chr22:41877989 A/G cg17376030 chr22:41985996 PMM1 -0.75 -7.97 -0.44 4.7e-14 Vitiligo; CESC cis rs6701037 1.000 rs7514749 chr1:175122123 A/G cg00321850 chr1:175162397 KIAA0040 -0.42 -5.86 -0.34 1.37e-8 Alcohol dependence; CESC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg09365446 chr1:150670422 GOLPH3L 0.4 5.68 0.33 3.53e-8 Tonsillectomy; CESC trans rs3780486 0.846 rs7849148 chr9:33138352 A/T cg04842962 chr6:43655489 MRPS18A 1.0 18.63 0.75 4.36e-50 IgG glycosylation; CESC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg04944784 chr2:26401820 FAM59B 0.91 9.37 0.5 3.37e-18 Gut microbiome composition (summer); CESC cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg27297192 chr10:134578999 INPP5A 0.43 5.68 0.33 3.62e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs10927875 0.632 rs2862162 chr1:16142960 A/C cg21385522 chr1:16154831 NA 0.99 15.92 0.7 1.7e-40 Dilated cardiomyopathy; CESC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.64 -0.33 4.43e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7927771 0.542 rs7102205 chr11:47745374 C/T cg20307385 chr11:47447363 PSMC3 0.6 8.55 0.46 1.01e-15 Subjective well-being; CESC cis rs9682041 0.696 rs6786542 chr3:170105378 C/T cg11886554 chr3:170076028 SKIL 0.69 6.33 0.36 1.02e-9 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs36051895 0.695 rs11794778 chr9:5023794 G/T cg02405213 chr9:5042618 JAK2 -0.51 -5.84 -0.34 1.49e-8 Pediatric autoimmune diseases; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11447699 chr10:99052509 ARHGAP19 -0.5 -6.03 -0.35 5.38e-9 Gut microbiome composition (summer); CESC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg24549020 chr5:56110836 MAP3K1 -0.59 -6.66 -0.38 1.54e-10 Initial pursuit acceleration; CESC cis rs7949030 0.626 rs61296092 chr11:62320838 T/C cg13298116 chr11:62369859 EML3;MTA2 0.65 9.56 0.51 8.58e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9911578 0.967 rs7503190 chr17:57184162 A/C cg05425664 chr17:57184151 TRIM37 -0.53 -7.31 -0.41 3.19e-12 Intelligence (multi-trait analysis); CESC cis rs61542988 0.756 rs5013587 chr7:22882660 C/T cg11367502 chr7:22862612 TOMM7 0.48 5.98 0.34 7.09e-9 Fibrinogen levels; CESC cis rs7957197 1.000 rs7957197 chr12:121460686 T/A cg02403541 chr12:121454288 C12orf43 -0.55 -5.04 -0.3 8.8e-7 Type 2 diabetes; CESC cis rs6980507 0.524 rs62510967 chr8:42441374 C/G cg09913449 chr8:42400586 C8orf40 0.32 5.04 0.3 8.5e-7 Glycated hemoglobin levels; CESC cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg00031303 chr3:195681400 NA 0.49 6.04 0.35 5.08e-9 Pancreatic cancer; CESC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Parkinson's disease; CESC cis rs3008870 1.000 rs12044278 chr1:67460977 T/C cg02640540 chr1:67518911 SLC35D1 -0.51 -5.58 -0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs8031584 0.918 rs35396566 chr15:31263057 T/C cg14298792 chr15:30685198 CHRFAM7A -0.47 -5.23 -0.31 3.46e-7 Huntington's disease progression; CESC cis rs12497850 0.863 rs4974084 chr3:48939080 G/A cg03060546 chr3:49711283 APEH 0.46 5.7 0.33 3.23e-8 Parkinson's disease; CESC cis rs1348850 0.526 rs10930802 chr2:178460095 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 5.25 0.31 3.15e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs17685 0.672 rs56343450 chr7:75796235 C/T cg19862616 chr7:65841803 NCRNA00174 0.84 12.03 0.59 6.77e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs3736485 0.934 rs7170330 chr15:51859313 C/T cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs35110281 0.805 rs162402 chr21:44963418 G/C cg21573476 chr21:45109991 RRP1B -0.42 -5.7 -0.33 3.13e-8 Mean corpuscular volume; CESC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg04267008 chr7:1944627 MAD1L1 -0.56 -6.59 -0.38 2.37e-10 Bipolar disorder and schizophrenia; CESC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg05617483 chr15:76483344 C15orf27 0.39 5.24 0.31 3.25e-7 Blood metabolite levels; CESC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg04315214 chr1:2043799 PRKCZ -0.42 -6.86 -0.39 4.84e-11 Height; CESC cis rs1707322 1.000 rs6682683 chr1:46342337 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10256972 0.528 rs7784607 chr7:1178694 A/G cg09177884 chr7:1199841 ZFAND2A -0.58 -7.66 -0.43 3.41e-13 Longevity;Endometriosis; CESC cis rs11864453 0.647 rs3764311 chr16:72125617 C/G cg01557791 chr16:72042693 DHODH -0.43 -5.57 -0.32 6.39e-8 Fibrinogen levels; CESC cis rs1707322 0.721 rs28442079 chr1:46172001 A/G cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2933343 1.000 rs789227 chr3:128600585 C/G cg25356066 chr3:128598488 ACAD9 0.6 7.55 0.42 6.86e-13 IgG glycosylation; CESC trans rs8073060 0.544 rs225246 chr17:33944773 T/C cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs1707322 0.752 rs4607935 chr1:46117161 C/T cg03146154 chr1:46216737 IPP 0.82 11.51 0.58 3.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg26998693 chr6:132834590 STX7 -0.41 -6.28 -0.36 1.39e-9 Vertical cup-disc ratio; CESC cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg03060546 chr3:49711283 APEH 0.43 5.34 0.31 2.05e-7 Parkinson's disease; CESC cis rs8114671 0.562 rs6088647 chr20:33505997 T/C cg07148914 chr20:33460835 GGT7 0.52 6.8 0.39 6.88e-11 Height; CESC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs6460942 0.597 rs17545416 chr7:12525944 A/T cg10578991 chr7:12443926 VWDE -0.49 -5.13 -0.3 5.63e-7 Coronary artery disease; CESC cis rs79349575 0.783 rs12601858 chr17:47017477 T/C cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22494505 chr1:26560657 CCDC21 0.54 6.01 0.35 6.2e-9 Gut microbiome composition (summer); CESC trans rs7246657 1.000 rs10426297 chr19:37798373 A/G cg01833234 chr11:6592585 DNHD1 0.54 6.13 0.35 3.19e-9 Coronary artery calcification; CESC cis rs9467711 0.606 rs34104395 chr6:26478252 C/T cg21479132 chr6:26055353 NA 0.74 5.07 0.3 7.56e-7 Autism spectrum disorder or schizophrenia; CESC trans rs11039798 0.764 rs2089208 chr11:48899860 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.44 0.37 5.66e-10 Axial length; CESC cis rs11122272 0.701 rs2749702 chr1:231523808 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs7267979 0.816 rs374701 chr20:25483616 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.71 0.67 3.22e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg10560079 chr2:191398806 TMEM194B -0.5 -7.26 -0.41 4.24e-12 Pulse pressure; CESC cis rs9649213 0.727 rs12113294 chr7:97910637 C/G cg21770322 chr7:97807741 LMTK2 0.42 5.85 0.34 1.45e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2559856 1.000 rs2695292 chr12:102087290 G/A cg12213457 chr12:102090980 CHPT1 -0.34 -5.1 -0.3 6.45e-7 Blood protein levels; CESC cis rs9287719 0.967 rs7563894 chr2:10754649 A/G cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC trans rs7577696 0.962 rs13022197 chr2:32343167 A/T cg13463167 chr1:197523608 DENND1B 0.37 6.18 0.35 2.38e-9 Inflammatory biomarkers; CESC cis rs2228479 0.681 rs11641790 chr16:89961957 A/G cg00800038 chr16:89945340 TCF25 0.59 6.52 0.37 3.61e-10 Skin colour saturation; CESC cis rs2243480 1.000 rs6949812 chr7:65387101 G/A cg25894440 chr7:65020034 NA -0.59 -5.03 -0.3 8.93e-7 Diabetic kidney disease; CESC cis rs6062302 0.522 rs2297427 chr20:62221364 G/A cg06363034 chr20:62225388 GMEB2 -0.52 -6.64 -0.38 1.74e-10 Glioblastoma; CESC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg14393609 chr7:65229607 NA -0.47 -6.33 -0.36 1.05e-9 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06757187 chr22:19110190 DGCR2 -0.43 -6.33 -0.36 1.03e-9 Gambling; CESC cis rs763121 0.853 rs138705 chr22:39133803 C/T cg21395723 chr22:39101663 GTPBP1 0.43 5.49 0.32 9.57e-8 Menopause (age at onset); CESC cis rs7100689 0.646 rs2994390 chr10:82074395 C/A cg00277334 chr10:82204260 NA -0.57 -7.5 -0.42 9.38e-13 Post bronchodilator FEV1; CESC cis rs4664308 0.618 rs55668231 chr2:160882066 A/G cg03641300 chr2:160917029 PLA2R1 -0.59 -8.37 -0.46 3.38e-15 Idiopathic membranous nephropathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13786801 chr1:59042745 TACSTD2 0.55 6.07 0.35 4.32e-9 Gut microbiome composition (summer); CESC cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg08069147 chr6:88032118 GJB7;C6orf162 0.72 9.98 0.52 4.07e-20 Monocyte percentage of white cells; CESC cis rs447 1.000 rs447 chr7:83772415 A/G cg22846510 chr7:83753280 SEMA3A -0.42 -5.09 -0.3 6.78e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg10862848 chr6:42927986 GNMT 0.27 6.84 0.39 5.43e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2070997 0.607 rs3808821 chr9:133712801 G/T cg14102055 chr9:133715238 ABL1 0.39 5.29 0.31 2.51e-7 Response to amphetamines; CESC cis rs1322639 0.614 rs6903921 chr6:169563957 C/T cg03254818 chr6:169586852 NA 0.48 5.22 0.31 3.57e-7 Pulse pressure; CESC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs73206853 0.764 rs16940935 chr12:111107470 A/G cg12870014 chr12:110450643 ANKRD13A 0.66 5.62 0.33 4.81e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01248421 chr18:32924572 ZNF24 0.44 6.19 0.36 2.31e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17666538 0.585 rs6559065 chr8:623156 G/C cg23958373 chr8:599963 NA 0.82 5.92 0.34 1.02e-8 IgG glycosylation; CESC cis rs66573146 0.634 rs55633489 chr4:6988745 C/A cg00086871 chr4:6988644 TBC1D14 1.18 8.17 0.45 1.25e-14 Granulocyte percentage of myeloid white cells; CESC cis rs910316 1.000 rs12589815 chr14:75544101 C/T cg08847533 chr14:75593920 NEK9 0.99 18.71 0.75 2.29e-50 Height; CESC cis rs919433 0.890 rs979020 chr2:198169749 T/C cg10820045 chr2:198174542 NA -0.41 -6.17 -0.35 2.49e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg18016565 chr1:150552671 MCL1 0.34 5.22 0.31 3.63e-7 Tonsillectomy; CESC cis rs12477438 1.000 rs73963398 chr2:99887025 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.14 -0.4 8.93e-12 Chronic sinus infection; CESC cis rs7249921 0.802 rs35746990 chr19:35666857 C/T cg15419183 chr19:35660584 FXYD5 0.54 8.39 0.46 2.95e-15 Platelet count; CESC cis rs7089973 0.604 rs2420066 chr10:116583897 A/G cg25233709 chr10:116636983 FAM160B1 0.35 5.47 0.32 1.05e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg04450456 chr4:17643702 FAM184B 0.37 5.18 0.3 4.46e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs2727020 0.755 rs652655 chr11:49251293 G/A cg03929089 chr4:120376271 NA 0.8 12.45 0.61 2.6e-28 Coronary artery disease; CESC cis rs4704187 0.687 rs2112874 chr5:74525165 G/A cg03227963 chr5:74354835 NA 0.28 5.04 0.3 8.66e-7 Response to amphetamines; CESC cis rs9905704 0.624 rs8080071 chr17:57093825 C/T cg12560992 chr17:57184187 TRIM37 -0.61 -7.51 -0.42 8.87e-13 Testicular germ cell tumor; CESC cis rs7703051 0.901 rs4549504 chr5:74808237 G/T cg03227963 chr5:74354835 NA 0.29 5.21 0.31 3.73e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs12530845 1.000 rs12531468 chr7:135336264 T/G cg23117316 chr7:135346802 PL-5283 -0.4 -5.15 -0.3 5.15e-7 Red blood cell traits; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg16763574 chr13:111937052 ARHGEF7 0.48 6.39 0.37 7.53e-10 Recombination measurement; CESC trans rs7246760 0.867 rs66880218 chr19:9774155 A/G cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs9640161 0.789 rs2159234 chr7:150020422 A/T cg21361702 chr7:150065534 REPIN1 0.54 6.23 0.36 1.84e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.54 7.31 0.41 3.13e-12 Lymphocyte counts; CESC cis rs72781680 0.533 rs56009471 chr2:23890084 A/C cg08917208 chr2:24149416 ATAD2B 1.0 9.69 0.51 3.24e-19 Lymphocyte counts; CESC cis rs7605827 0.897 rs6431694 chr2:15523031 T/C cg19274914 chr2:15703543 NA 0.35 6.11 0.35 3.61e-9 Educational attainment (years of education); CESC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg25985355 chr7:65971099 NA 0.32 5.34 0.31 2e-7 Aortic root size; CESC cis rs7799006 0.755 rs2256545 chr7:2291943 G/A cg08027265 chr7:2291960 NA -0.56 -9.82 -0.52 1.33e-19 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg12463550 chr7:65579703 CRCP -0.6 -7.4 -0.41 1.78e-12 Aortic root size; CESC trans rs7839040 0.698 rs10093631 chr8:82921021 A/T cg14472086 chr9:107730925 NA -0.46 -6.25 -0.36 1.61e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -5.56 -0.32 6.65e-8 Monocyte percentage of white cells; CESC cis rs897080 0.515 rs786616 chr2:44592975 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.51 6.0 0.35 6.57e-9 Height; CESC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.97 9.66 0.51 4.13e-19 Platelet count; CESC cis rs1707322 0.752 rs11211173 chr1:46219376 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10876993 0.928 rs10877001 chr12:58083077 T/C cg18357645 chr12:58087776 OS9 -0.66 -10.82 -0.55 7.8e-23 Celiac disease or Rheumatoid arthritis; CESC cis rs11676348 0.846 rs4674260 chr2:219002376 T/C cg00012203 chr2:219082015 ARPC2 -0.59 -7.7 -0.43 2.68e-13 Ulcerative colitis; CESC cis rs684232 0.688 rs2657633 chr17:600502 C/T cg12384639 chr17:618140 VPS53 0.4 5.24 0.31 3.26e-7 Prostate cancer; CESC cis rs3796619 1.000 rs1466215 chr4:1072220 C/T cg27284194 chr4:1044797 NA 0.36 5.5 0.32 9.08e-8 Recombination rate (males); CESC cis rs3733585 0.699 rs57574512 chr4:9960182 T/C cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.18 0.3 4.3e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg12756686 chr19:29218302 NA 0.58 7.52 0.42 8.38e-13 Methadone dose in opioid dependence; CESC cis rs10883723 0.810 rs10786669 chr10:104256094 C/G cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Allergic disease (asthma, hay fever or eczema); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26994227 chr5:130971071 RAPGEF6 0.67 7.92 0.44 6.51e-14 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04618842 chr12:57472555 TMEM194A -0.43 -6.06 -0.35 4.54e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11122272 0.733 rs2749700 chr1:231522734 A/G cg06096015 chr1:231504339 EGLN1 0.41 5.85 0.34 1.46e-8 Hemoglobin concentration; CESC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.48 0.32 9.95e-8 Depression; CESC cis rs6674176 0.932 rs4660761 chr1:44440146 G/A cg12908607 chr1:44402522 ARTN -0.45 -6.19 -0.36 2.24e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1153858 0.943 rs4774580 chr15:45652086 G/A cg21132104 chr15:45694354 SPATA5L1 0.85 11.64 0.58 1.47e-25 Homoarginine levels; CESC cis rs1580019 0.523 rs9791770 chr7:32582252 C/A cg06627557 chr7:32535165 LSM5;AVL9 1.07 18.41 0.75 2.5e-49 Cognitive ability; CESC trans rs7824557 0.527 rs2572448 chr8:11239352 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -6.11 -0.35 3.59e-9 Retinal vascular caliber; CESC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg00484396 chr16:3507460 NAT15 0.59 6.47 0.37 4.8e-10 Tuberculosis; CESC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -10.95 -0.56 2.97e-23 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26468130 chr11:64053342 BAD;GPR137 0.54 6.05 0.35 5.02e-9 Gut microbiome composition (summer); CESC cis rs6540556 0.723 rs3766619 chr1:209895298 C/G cg05527609 chr1:210001259 C1orf107 -0.66 -7.32 -0.41 2.95e-12 Red blood cell count; CESC cis rs3736485 0.934 rs17609666 chr15:51858038 G/T cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2228479 0.850 rs11639925 chr16:89908250 C/T cg00800038 chr16:89945340 TCF25 -0.9 -6.93 -0.39 3.24e-11 Skin colour saturation; CESC cis rs30380 0.666 rs26512 chr5:96128400 G/T cg16492584 chr5:96139282 ERAP1 -0.47 -6.59 -0.38 2.33e-10 Cerebrospinal fluid biomarker levels; CESC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs7267979 0.706 rs6138542 chr20:25207773 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 14.78 0.67 1.86e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg19346786 chr7:2764209 NA -0.49 -7.09 -0.4 1.19e-11 Height; CESC cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg17366294 chr4:99064904 C4orf37 0.58 8.3 0.45 5.45e-15 Colonoscopy-negative controls vs population controls; CESC cis rs8077577 0.747 rs62072540 chr17:18225228 G/A cg16794390 chr17:18148240 FLII 0.4 6.24 0.36 1.75e-9 Obesity-related traits; CESC cis rs17125944 0.505 rs77137752 chr14:53230496 G/T cg00686598 chr14:53173677 PSMC6 1.36 11.65 0.58 1.34e-25 Alzheimer's disease (late onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13184734 chr1:178512007 C1orf220 -0.44 -6.06 -0.35 4.55e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1371867 0.775 rs3020183 chr8:101233297 A/T cg11906718 chr8:101322791 RNF19A -0.49 -6.18 -0.36 2.36e-9 Atrioventricular conduction; CESC cis rs116095464 1.000 rs7723693 chr5:306032 G/A cg10591111 chr5:226296 SDHA -0.65 -5.92 -0.34 9.71e-9 Breast cancer; CESC cis rs11764590 0.694 rs7801349 chr7:2085553 T/C cg21782813 chr7:2030301 MAD1L1 -0.4 -5.37 -0.31 1.73e-7 Neuroticism; CESC cis rs7980687 0.628 rs2102949 chr12:123676763 G/A cg05973401 chr12:123451056 ABCB9 0.46 5.75 0.33 2.41e-8 Height;Educational attainment;Head circumference (infant); CESC cis rs362272 0.505 rs10155132 chr4:3369500 A/G cg08886695 chr4:3369023 RGS12 -0.39 -5.38 -0.31 1.64e-7 Serum sulfate level; CESC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg21770322 chr7:97807741 LMTK2 0.55 8.3 0.45 5.5e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs11650494 0.808 rs61286260 chr17:47433222 T/C cg08112188 chr17:47440006 ZNF652 0.83 6.24 0.36 1.71e-9 Prostate cancer; CESC cis rs2074585 0.517 rs11638010 chr15:91079920 A/G cg22089800 chr15:90895588 ZNF774 -0.43 -5.15 -0.3 5e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs2354432 0.556 rs2275249 chr1:146759320 C/G cg25205988 chr1:146714368 CHD1L 0.88 7.89 0.44 8.17e-14 Mitochondrial DNA levels; CESC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg19901468 chr14:105411992 AHNAK2 -0.6 -8.69 -0.47 3.79e-16 Rheumatoid arthritis; CESC cis rs2299587 0.582 rs17515033 chr8:17898518 A/T cg18067069 chr8:17937731 ASAH1 -0.37 -5.03 -0.3 8.86e-7 Economic and political preferences; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18103236 chr10:81060645 ZMIZ1 -0.57 -6.22 -0.36 1.95e-9 Gut microbiome composition (summer); CESC cis rs10883723 0.810 rs11191304 chr10:104255284 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs2109514 0.902 rs1007751 chr7:116110055 A/T cg12739419 chr7:116140593 CAV2 -0.38 -6.85 -0.39 5.28e-11 Prevalent atrial fibrillation; CESC cis rs2463822 0.583 rs7104825 chr11:62026833 C/T cg06239285 chr11:62104954 ASRGL1 -0.92 -7.01 -0.4 1.99e-11 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg18758796 chr5:131593413 PDLIM4 0.46 6.66 0.38 1.57e-10 Breast cancer; CESC cis rs7727544 0.684 rs272889 chr5:131665378 A/G cg24060327 chr5:131705240 SLC22A5 -0.63 -8.22 -0.45 9.15e-15 Blood metabolite levels; CESC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg11644478 chr21:40555479 PSMG1 1.02 16.23 0.71 1.32e-41 Cognitive function; CESC cis rs5753618 0.583 rs7293171 chr22:31802324 T/C cg02404636 chr22:31891804 SFI1 0.39 5.14 0.3 5.35e-7 Colorectal cancer; CESC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.15 0.4 8.26e-12 Height; CESC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg19592336 chr6:28129416 ZNF389 -0.59 -7.71 -0.43 2.55e-13 Depression; CESC cis rs703842 0.963 rs923829 chr12:58174306 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.7 9.11 0.49 2.09e-17 Multiple sclerosis; CESC cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6976053 0.518 rs314358 chr7:100410657 A/G cg03098644 chr7:100410630 EPHB4 -0.51 -6.76 -0.38 8.92e-11 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs7264396 0.635 rs6058358 chr20:34492560 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.23 -0.57 3.44e-24 Total cholesterol levels; CESC cis rs7178909 0.866 rs3784388 chr15:90437301 C/T cg19708238 chr15:90437601 AP3S2 0.43 6.19 0.36 2.25e-9 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15277658 chr10:73421701 CDH23 0.5 6.25 0.36 1.63e-9 Gut microbiome composition (summer); CESC cis rs1670533 1.000 rs10007978 chr4:1060984 A/T cg04106633 chr4:1044584 NA 0.4 5.19 0.3 4.15e-7 Recombination rate (females); CESC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.03e-11 Tonsillectomy; CESC cis rs2882667 0.858 rs11741150 chr5:138431457 C/T cg04439458 chr5:138467593 SIL1 -0.43 -6.58 -0.37 2.51e-10 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg02297831 chr4:17616191 MED28 0.6 7.67 0.43 3.22e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3806843 0.966 rs3806842 chr5:140212676 C/T cg26395211 chr5:140044315 WDR55 -0.4 -5.18 -0.3 4.4e-7 Depressive symptoms (multi-trait analysis); CESC cis rs8177253 0.555 rs4481157 chr3:133464684 G/A cg24879335 chr3:133465180 TF 0.36 6.55 0.37 2.97e-10 Iron status biomarkers; CESC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg07701084 chr6:150067640 NUP43 0.43 5.78 0.33 2.13e-8 Lung cancer; CESC cis rs9300255 0.539 rs1969355 chr12:123742061 G/A cg00376283 chr12:123451042 ABCB9 0.65 8.73 0.47 2.86e-16 Neutrophil percentage of white cells; CESC trans rs208520 1.000 rs72882079 chr6:66973878 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 9.39 0.5 2.78e-18 Exhaled nitric oxide output; CESC cis rs12476592 0.602 rs6724160 chr2:63786423 G/C cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs9486715 0.758 rs9386528 chr6:96928514 G/A cg06623918 chr6:96969491 KIAA0776 -0.82 -10.96 -0.56 2.73e-23 Headache; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13411879 chr7:30068273 PLEKHA8 -0.41 -6.12 -0.35 3.3e-9 Ulcerative colitis; CESC cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg05585544 chr11:47624801 NA -0.51 -7.32 -0.41 3.01e-12 Subjective well-being; CESC cis rs2996428 0.504 rs3765780 chr1:3767696 C/T cg13057898 chr1:3703894 LRRC47 -0.33 -5.37 -0.31 1.69e-7 Red cell distribution width; CESC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg16145915 chr7:1198662 ZFAND2A -0.48 -6.77 -0.38 8.14e-11 Longevity;Endometriosis; CESC cis rs8114671 0.836 rs6142284 chr20:33641367 G/A cg06115741 chr20:33292138 TP53INP2 -0.44 -5.29 -0.31 2.53e-7 Height; CESC cis rs2243480 1.000 rs13235972 chr7:65883605 C/T cg18252515 chr7:66147081 NA -1.39 -14.18 -0.66 2.5e-34 Diabetic kidney disease; CESC trans rs853679 0.546 rs17695758 chr6:27837183 T/C cg06606381 chr12:133084897 FBRSL1 -1.07 -8.89 -0.48 9.48e-17 Depression; CESC cis rs13242816 1.000 rs2402079 chr7:116128670 T/A cg04696780 chr7:116139425 CAV2 -0.61 -5.56 -0.32 6.58e-8 P wave duration; CESC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg22920501 chr2:26401640 FAM59B -0.67 -8.09 -0.44 2.22e-14 Gut microbiome composition (summer); CESC cis rs7605827 0.930 rs11684001 chr2:15513120 C/T cg19274914 chr2:15703543 NA 0.32 5.58 0.32 5.95e-8 Educational attainment (years of education); CESC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg24733560 chr20:60626293 TAF4 0.45 6.44 0.37 5.45e-10 Body mass index; CESC cis rs7223966 1.000 rs28463311 chr17:61919643 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 5.73 0.33 2.66e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs11997175 0.516 rs6981283 chr8:33619363 A/G ch.8.33884649F chr8:33765107 NA 0.57 7.35 0.41 2.5e-12 Body mass index; CESC cis rs1152591 0.505 rs1152601 chr14:64667337 T/C cg23250157 chr14:64679961 SYNE2 0.41 5.82 0.34 1.7e-8 Atrial fibrillation; CESC cis rs3812831 0.662 rs407531 chr13:114929218 G/A cg08824895 chr13:115047677 UPF3A 0.39 5.16 0.3 4.83e-7 Schizophrenia; CESC cis rs3947 0.855 rs1296026 chr8:11697442 C/T cg00262122 chr8:11665843 FDFT1 -0.51 -5.2 -0.3 4.02e-7 Blood protein levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09983252 chr4:119555556 NA -0.41 -6.02 -0.35 5.78e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg04166393 chr7:2884313 GNA12 0.6 7.91 0.44 7.05e-14 Height; CESC cis rs2708240 1.000 rs2538989 chr7:147580154 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.67 -0.33 3.73e-8 QT interval (drug interaction); CESC cis rs7084402 0.967 rs7091440 chr10:60271372 T/A cg07615347 chr10:60278583 BICC1 -0.57 -8.63 -0.47 5.58e-16 Refractive error; CESC cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg05347473 chr6:146136440 FBXO30 -0.59 -7.02 -0.4 1.87e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs3780486 0.718 rs7859454 chr9:33119583 T/A cg13443165 chr9:33130375 B4GALT1 0.44 5.37 0.31 1.76e-7 IgG glycosylation; CESC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.64 -0.51 4.86e-19 Alzheimer's disease; CESC cis rs8180040 0.900 rs10865946 chr3:47425060 T/G cg27129171 chr3:47204927 SETD2 0.63 9.65 0.51 4.34e-19 Colorectal cancer; CESC cis rs17102884 0.506 rs11845397 chr14:75404587 G/A cg08847533 chr14:75593920 NEK9 -0.44 -5.49 -0.32 9.41e-8 Neuroticism; CESC cis rs8060686 0.641 rs76501820 chr16:68114582 G/A cg26727032 chr16:67993705 SLC12A4 -0.58 -6.32 -0.36 1.11e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs2832191 0.755 rs55671430 chr21:30492421 G/C cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.63e-20 Dental caries; CESC cis rs4722166 0.508 rs2069832 chr7:22767433 A/G cg26061582 chr7:22766209 IL6 0.47 5.39 0.31 1.58e-7 Lung cancer; CESC cis rs1707322 0.865 rs785501 chr1:46579611 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.63 -0.33 4.67e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg18876405 chr7:65276391 NA -0.5 -6.41 -0.37 6.47e-10 Aortic root size; CESC cis rs10504073 0.545 rs4406405 chr8:49957261 G/C cg00325661 chr8:49890786 NA 0.59 8.9 0.48 9.3e-17 Blood metabolite ratios; CESC cis rs67311347 1.000 rs73078169 chr3:40483798 G/A cg24209194 chr3:40518798 ZNF619 0.5 6.21 0.36 2e-9 Renal cell carcinoma; CESC cis rs7208859 0.623 rs77544470 chr17:28934550 C/A cg19761014 chr17:28927070 LRRC37B2 0.82 6.21 0.36 2.01e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg24209194 chr3:40518798 ZNF619 -0.54 -7.24 -0.41 4.73e-12 Renal cell carcinoma; CESC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.02 10.3 0.53 3.86e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6502050 0.835 rs12945993 chr17:80129485 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.7e-7 Life satisfaction; CESC cis rs4595586 0.679 rs1356264 chr12:39393754 A/T cg26384229 chr12:38710491 ALG10B 0.43 6.28 0.36 1.35e-9 Morning vs. evening chronotype; CESC cis rs3126085 0.935 rs1390485 chr1:152182168 C/T cg03465714 chr1:152285911 FLG 0.44 5.25 0.31 3.16e-7 Atopic dermatitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08466385 chr6:18368294 NA -0.43 -6.18 -0.35 2.37e-9 Gut microbiota (bacterial taxa); CESC cis rs12477438 0.520 rs12621007 chr2:99791946 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.08 0.68 1.62e-37 Chronic sinus infection; CESC cis rs854765 0.551 rs56886154 chr17:17831473 C/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.36 0.36 8.96e-10 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21138277 chr11:93276595 C11orf75 0.55 6.44 0.37 5.73e-10 Gut microbiome composition (summer); CESC cis rs66887589 0.616 rs10032299 chr4:120206419 C/T cg09307838 chr4:120376055 NA 0.67 9.24 0.49 8.04e-18 Diastolic blood pressure; CESC cis rs4803455 0.565 rs1800470 chr19:41858921 G/A cg09537434 chr19:41945824 ATP5SL -0.71 -9.67 -0.51 3.78e-19 Migraine;Coronary artery disease; CESC cis rs7772486 0.875 rs9390372 chr6:146363638 G/C cg23711669 chr6:146136114 FBXO30 0.83 12.12 0.6 3.46e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs61869271 0.799 rs35501899 chr10:116739109 T/G cg17463145 chr7:79084011 MAGI2 0.32 6.36 0.36 8.92e-10 Tonsillectomy; CESC trans rs61931739 0.500 rs7979482 chr12:34542877 C/A cg13010199 chr12:38710504 ALG10B 0.52 6.67 0.38 1.49e-10 Morning vs. evening chronotype; CESC cis rs722599 0.748 rs2300599 chr14:75359441 A/G cg11812906 chr14:75593930 NEK9 -0.47 -5.72 -0.33 2.83e-8 IgG glycosylation; CESC cis rs2882667 0.858 rs11242442 chr5:138380489 C/T cg04439458 chr5:138467593 SIL1 -0.4 -6.15 -0.35 2.89e-9 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg11152298 chr5:142783383 NR3C1 -0.5 -6.18 -0.35 2.46e-9 Gut microbiota (bacterial taxa); CESC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.48 -6.01 -0.35 6.02e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2455799 0.634 rs13085226 chr3:15923750 C/T cg16303742 chr3:15540471 COLQ -0.34 -5.23 -0.31 3.47e-7 Mean platelet volume; CESC cis rs911555 0.755 rs34411783 chr14:103900639 G/A cg12935359 chr14:103987150 CKB 0.61 9.0 0.48 4.35e-17 Intelligence (multi-trait analysis); CESC cis rs6723226 0.806 rs6543658 chr2:32718849 G/A cg02381751 chr2:32503542 YIPF4 0.8 11.56 0.58 2.72e-25 Intelligence (multi-trait analysis); CESC cis rs9640161 0.830 rs13307276 chr7:150061525 T/C cg17279839 chr7:150038598 RARRES2 0.42 5.4 0.31 1.5e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg03934478 chr11:495069 RNH1 0.52 5.04 0.3 8.51e-7 Body mass index; CESC cis rs4660261 0.562 rs3011223 chr1:44318286 T/C cg12908607 chr1:44402522 ARTN -0.46 -6.6 -0.38 2.29e-10 Intelligence (multi-trait analysis); CESC cis rs10504073 0.584 rs55795863 chr8:49898055 A/G cg00325661 chr8:49890786 NA 0.56 8.46 0.46 1.82e-15 Blood metabolite ratios; CESC cis rs2050392 0.624 rs303444 chr10:30729347 C/T cg02070205 chr10:30722105 MAP3K8 -0.43 -5.15 -0.3 5.03e-7 Inflammatory bowel disease; CESC cis rs10781543 0.817 rs1128874 chr9:139323424 T/C cg14019695 chr9:139328340 INPP5E 0.34 5.04 0.3 8.49e-7 Monocyte percentage of white cells; CESC cis rs1707322 1.000 rs10890370 chr1:46389217 C/T cg05343316 chr1:45956843 TESK2 0.45 5.52 0.32 8e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.19 0.45 1.08e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg05347473 chr6:146136440 FBXO30 -0.71 -9.16 -0.49 1.42e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs1153858 1.000 rs1346266 chr15:45694516 G/T cg21132104 chr15:45694354 SPATA5L1 0.78 10.32 0.54 3.19e-21 Homoarginine levels; CESC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg07677032 chr17:61819896 STRADA 0.41 5.33 0.31 2.15e-7 Prudent dietary pattern; CESC cis rs11638352 1.000 rs958485 chr15:44350065 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.66 -6.28 -0.36 1.35e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs11098499 0.865 rs10032158 chr4:120391632 C/T cg24375607 chr4:120327624 NA 0.45 5.59 0.32 5.56e-8 Corneal astigmatism; CESC cis rs7786877 0.626 rs11767547 chr7:100221635 C/T cg16850897 chr7:100343110 ZAN -0.62 -6.54 -0.37 3.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg07507251 chr3:52567010 NT5DC2 0.43 7.47 0.42 1.19e-12 Bipolar disorder; CESC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg06634786 chr22:41940651 POLR3H 0.68 6.78 0.38 7.6e-11 Vitiligo; CESC cis rs801193 0.591 rs9986881 chr7:66173040 A/G cg25405998 chr7:65216604 CCT6P1 0.4 5.17 0.3 4.68e-7 Aortic root size; CESC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg27170947 chr2:26402098 FAM59B -0.6 -7.23 -0.41 5.28e-12 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs62346508 chr5:203668 T/C cg16372103 chr5:203701 NA 0.49 5.3 0.31 2.4e-7 Breast cancer; CESC cis rs9487051 0.714 rs7757347 chr6:109633815 G/A cg01475377 chr6:109611718 NA -0.45 -6.96 -0.39 2.6e-11 Reticulocyte fraction of red cells; CESC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg05340658 chr4:99064831 C4orf37 0.81 12.59 0.61 8.13e-29 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg14393609 chr7:65229607 NA 0.41 5.57 0.32 6.1e-8 Aortic root size; CESC cis rs4454254 1.000 rs4440615 chr8:141057641 G/A cg06693505 chr8:141057453 TRAPPC9 -0.35 -5.72 -0.33 2.93e-8 Pulse pressure; CESC cis rs3096299 0.935 rs3114890 chr16:89449546 C/G cg00750074 chr16:89608354 SPG7 -0.38 -5.32 -0.31 2.16e-7 Multiple myeloma (IgH translocation); CESC cis rs9611565 0.504 rs5758452 chr22:42144927 G/A cg03806693 chr22:41940476 POLR3H 0.79 9.66 0.51 4.04e-19 Vitiligo; CESC cis rs6460942 0.915 rs7802454 chr7:12454508 A/G cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC cis rs7824557 0.564 rs2572400 chr8:11234367 T/G cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.47e-14 Retinal vascular caliber; CESC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg02574844 chr11:5959923 NA -0.46 -6.5 -0.37 3.99e-10 DNA methylation (variation); CESC cis rs72781680 1.000 rs72788286 chr2:24098321 A/C cg08917208 chr2:24149416 ATAD2B 0.91 8.38 0.46 3.17e-15 Lymphocyte counts; CESC cis rs7084402 0.967 rs1658477 chr10:60289607 A/G cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs7089973 0.872 rs7909657 chr10:116629096 C/G cg23260525 chr10:116636907 FAM160B1 0.38 6.42 0.37 6.35e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00712792 chr16:89921048 SPIRE2 0.47 6.56 0.37 2.77e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10715820 chr1:17235063 NA -0.55 -6.34 -0.36 9.68e-10 Gut microbiome composition (summer); CESC cis rs897984 0.806 rs1046276 chr16:30914626 A/G cg00531865 chr16:30841666 NA 0.53 7.07 0.4 1.36e-11 Dementia with Lewy bodies; CESC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg12463550 chr7:65579703 CRCP -0.5 -6.34 -0.36 9.71e-10 Aortic root size; CESC cis rs9814567 0.896 rs58491661 chr3:134355189 G/T cg15484384 chr3:134203672 ANAPC13;CEP63 0.32 5.23 0.31 3.52e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg07936489 chr17:37558343 FBXL20 0.83 12.18 0.6 2.11e-27 Glomerular filtration rate (creatinine); CESC cis rs6665290 0.904 rs1045286 chr1:227179037 A/C cg10327440 chr1:227177885 CDC42BPA 1.16 31.06 0.89 2.64e-90 Myeloid white cell count; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg16882830 chr7:148823965 ZNF398;ZNF425 -0.47 -6.05 -0.35 4.83e-9 Recombination measurement; CESC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.14 0.56 6.75e-24 Alzheimer's disease; CESC cis rs9583531 0.689 rs1061386 chr13:111373368 G/C cg24331049 chr13:111365604 ING1 0.7 9.59 0.51 6.68e-19 Coronary artery disease; CESC cis rs1707322 0.928 rs6681068 chr1:46398382 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7851660 0.809 rs35324451 chr9:100660136 A/T cg13688889 chr9:100608707 NA -0.59 -8.1 -0.45 2.03e-14 Strep throat; CESC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg19729930 chr2:74357872 NA 0.79 11.51 0.58 3.95e-25 Gestational age at birth (maternal effect); CESC cis rs6866344 0.697 rs11749438 chr5:178131245 C/T cg03877680 chr5:178157825 ZNF354A 0.75 8.54 0.46 1.08e-15 Neutrophil percentage of white cells; CESC cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg02187348 chr16:89574699 SPG7 0.59 8.02 0.44 3.43e-14 Multiple myeloma (IgH translocation); CESC cis rs1461503 0.932 rs11218909 chr11:122842613 C/T cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.92 8.92 0.48 8e-17 Platelet count; CESC cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg26597838 chr10:835615 NA 0.86 8.98 0.48 5.16e-17 Eosinophil percentage of granulocytes; CESC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg20933634 chr6:27740509 NA -0.4 -5.12 -0.3 5.8e-7 Parkinson's disease; CESC cis rs1348850 0.831 rs7606235 chr2:178401288 T/C cg23306229 chr2:178417860 TTC30B 0.61 7.36 0.41 2.33e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs35110281 0.743 rs2329443 chr21:45059431 C/T cg21573476 chr21:45109991 RRP1B -0.55 -7.54 -0.42 7.34e-13 Mean corpuscular volume; CESC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg25036284 chr2:26402008 FAM59B 0.84 8.75 0.47 2.61e-16 Gut microbiome composition (summer); CESC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg03576123 chr11:487126 PTDSS2 -1.12 -11.21 -0.57 3.93e-24 Body mass index; CESC cis rs8018808 0.905 rs7142380 chr14:77931231 T/C cg20045696 chr14:77926864 AHSA1 0.43 5.9 0.34 1.13e-8 Myeloid white cell count; CESC cis rs9894429 0.716 rs7405578 chr17:79588306 C/A cg18240062 chr17:79603768 NPLOC4 0.89 13.31 0.63 2.64e-31 Eye color traits; CESC cis rs7607369 0.536 rs13013510 chr2:219667227 A/G cg02176678 chr2:219576539 TTLL4 -0.35 -6.13 -0.35 3.12e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg23048001 chr7:2026167 MAD1L1 0.39 5.04 0.3 8.75e-7 Bipolar disorder and schizophrenia; CESC cis rs7772486 0.686 rs9497396 chr6:146014963 C/A cg05347473 chr6:146136440 FBXO30 -0.51 -6.55 -0.37 2.92e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9486719 1.000 rs11153023 chr6:96968525 C/T cg06623918 chr6:96969491 KIAA0776 -0.77 -7.52 -0.42 8.36e-13 Migraine;Coronary artery disease; CESC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg02951883 chr7:2050386 MAD1L1 -0.53 -7.1 -0.4 1.16e-11 Bipolar disorder and schizophrenia; CESC cis rs2933343 0.903 rs2638846 chr3:128587163 A/T cg25356066 chr3:128598488 ACAD9 0.55 6.93 0.39 3.13e-11 IgG glycosylation; CESC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.08 -0.4 1.26e-11 Gut microbiome composition (summer); CESC cis rs2637266 0.685 rs7098713 chr10:78452828 C/T cg18941641 chr10:78392320 NA 0.43 7.82 0.43 1.23e-13 Pulmonary function; CESC cis rs6693567 0.565 rs4926422 chr1:150315436 T/C cg09579323 chr1:150459698 TARS2 0.49 6.28 0.36 1.35e-9 Migraine; CESC trans rs9646096 0.558 rs9547858 chr13:38002795 A/G cg24730915 chr19:7570267 C19orf45 0.63 6.04 0.35 5.25e-9 Age-related macular degeneration; CESC cis rs911555 0.504 rs61995761 chr14:104075712 T/C cg12935359 chr14:103987150 CKB -0.5 -7.3 -0.41 3.29e-12 Intelligence (multi-trait analysis); CESC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg04369109 chr6:150039330 LATS1 -0.43 -6.04 -0.35 5.1e-9 Lung cancer; CESC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg15052019 chr19:19431593 KIAA0892;SF4 -0.42 -5.39 -0.31 1.53e-7 Tonsillectomy; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg25422665 chr17:16485103 NA 0.48 6.35 0.36 9.08e-10 Thyroid stimulating hormone; CESC cis rs2425143 1.000 rs11696527 chr20:34245379 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -7.54 -0.42 7.65e-13 Blood protein levels; CESC cis rs6121246 0.529 rs56153385 chr20:30187609 C/T cg13852791 chr20:30311386 BCL2L1 0.67 6.71 0.38 1.2e-10 Mean corpuscular hemoglobin; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05176433 chr10:95242154 MYOF 0.47 6.36 0.36 8.63e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg23281280 chr6:28129359 ZNF389 0.58 8.05 0.44 2.72e-14 Depression; CESC cis rs10870270 0.912 rs7079991 chr10:133736130 A/G cg26149184 chr10:133730230 NA 0.38 5.15 0.3 5.07e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2075371 1.000 rs2598297 chr7:133993001 T/G cg20476274 chr7:133979776 SLC35B4 0.67 9.68 0.51 3.52e-19 Mean platelet volume; CESC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 8.34 0.46 4.21e-15 Platelet count; CESC cis rs4948102 0.731 rs4535700 chr7:56045448 T/C cg09872392 chr7:56161020 PHKG1 -0.46 -7.13 -0.4 9.34e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.0 0.8 9.67e-62 Prudent dietary pattern; CESC cis rs2050392 1.000 rs2265186 chr10:30691743 C/T cg18806716 chr10:30721971 MAP3K8 0.39 5.47 0.32 1.04e-7 Inflammatory bowel disease; CESC cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC trans rs9325144 0.624 rs7312879 chr12:39150752 G/A cg23762105 chr12:34175262 ALG10 0.46 6.0 0.35 6.45e-9 Morning vs. evening chronotype; CESC cis rs9911578 0.967 rs11656413 chr17:57082013 A/C cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.08 -0.3 7.13e-7 Intelligence (multi-trait analysis); CESC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg05872129 chr22:39784769 NA 0.72 9.83 0.52 1.22e-19 IgG glycosylation; CESC cis rs258892 0.895 rs13174766 chr5:72057135 C/T cg21869765 chr5:72125136 TNPO1 -0.43 -5.36 -0.31 1.84e-7 Small cell lung carcinoma; CESC cis rs3096299 0.591 rs748940 chr16:89440757 T/A cg08822215 chr16:89438651 ANKRD11 -0.44 -6.68 -0.38 1.42e-10 Multiple myeloma (IgH translocation); CESC cis rs3126085 0.935 rs72696997 chr1:152257099 A/C cg03465714 chr1:152285911 FLG 0.49 5.43 0.32 1.24e-7 Atopic dermatitis; CESC cis rs9399135 0.967 rs9389261 chr6:135371148 C/G cg24558204 chr6:135376177 HBS1L 0.49 6.77 0.38 8.11e-11 Red blood cell count; CESC cis rs11792861 0.555 rs4978767 chr9:111762925 C/T cg05043794 chr9:111880884 C9orf5 -0.3 -5.33 -0.31 2.11e-7 Menarche (age at onset); CESC cis rs2760061 0.583 rs697763 chr1:228192622 G/C cg02753203 chr1:228287806 NA 0.79 11.5 0.58 4.28e-25 Diastolic blood pressure; CESC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 10.64 0.55 2.98e-22 Platelet count; CESC cis rs360798 0.532 rs13013218 chr2:63011671 C/T cg17519650 chr2:63277830 OTX1 -0.57 -7.54 -0.42 7.37e-13 Coronary artery disease; CESC cis rs568617 1.000 rs694994 chr11:65653309 A/G cg19792802 chr11:65647270 CTSW 0.36 5.44 0.32 1.2e-7 Crohn's disease; CESC trans rs9398803 0.965 rs2326387 chr6:126680489 G/A cg03991309 chr1:68237761 GNG12 -0.39 -6.04 -0.35 5.23e-9 Male-pattern baldness; CESC trans rs208520 0.874 rs208470 chr6:66916402 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.84 -9.91 -0.52 6.69e-20 Exhaled nitric oxide output; CESC cis rs698813 0.604 rs1988663 chr2:44492753 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.4 0.32 1.45e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs1256061 0.624 rs1760988 chr14:64696813 A/G cg23250157 chr14:64679961 SYNE2 0.52 7.37 0.41 2.22e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17322163 chr12:51632344 DAZAP2 -0.45 -6.04 -0.35 5.3e-9 Fibrinogen levels; CESC cis rs1062177 1.000 rs2915880 chr5:151147334 G/A cg12924095 chr5:151150029 G3BP1 0.48 6.2 0.36 2.21e-9 Preschool internalizing problems; CESC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg10295955 chr4:187884368 NA -1.07 -22.28 -0.81 1.14e-62 Lobe attachment (rater-scored or self-reported); CESC cis rs6987853 0.830 rs2272685 chr8:42354102 C/T cg09913449 chr8:42400586 C8orf40 -0.34 -5.3 -0.31 2.38e-7 Mean corpuscular hemoglobin concentration; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13787782 chr2:239161568 PER2 -0.49 -6.42 -0.37 6.19e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11361923 1 rs11361923 chr14:77862679 GC/G cg20045696 chr14:77926864 AHSA1 -0.44 -5.92 -0.34 1.01e-8 Sum basophil neutrophil counts;White blood cell count;Granulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10978402 chr15:90931990 IQGAP1 0.64 7.09 0.4 1.21e-11 Gut microbiome composition (summer); CESC cis rs2251381 0.750 rs2776250 chr21:30528094 T/G cg24692254 chr21:30365293 RNF160 0.78 10.6 0.55 4.11e-22 Selective IgA deficiency; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01761420 chr6:106534239 PRDM1 0.55 6.35 0.36 9.22e-10 Gut microbiome composition (summer); CESC cis rs965469 0.895 rs6037595 chr20:3401128 T/G cg25506879 chr20:3388711 C20orf194 -0.61 -6.46 -0.37 4.98e-10 IFN-related cytopenia; CESC cis rs2243480 1.000 rs12698509 chr7:65418876 C/T cg13147721 chr7:65941812 NA -0.86 -8.63 -0.47 5.6e-16 Diabetic kidney disease; CESC cis rs7635838 0.859 rs6779840 chr3:11425423 A/G cg00170343 chr3:11313890 ATG7 0.42 5.61 0.33 5.14e-8 HDL cholesterol; CESC cis rs7918232 0.830 rs7087033 chr10:27392522 A/G cg14442939 chr10:27389572 ANKRD26 0.83 8.27 0.45 6.65e-15 Breast cancer; CESC cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg05283184 chr6:79620031 NA 0.42 6.59 0.38 2.38e-10 Intelligence (multi-trait analysis); CESC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 10.61 0.55 3.66e-22 Platelet count; CESC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 13.02 0.62 2.79e-30 Platelet count; CESC cis rs1355223 0.545 rs7106831 chr11:34879542 T/C cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.58 -0.37 2.5e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs959260 0.557 rs4788887 chr17:73323876 C/G cg20590849 chr17:73267439 MIF4GD -0.44 -5.19 -0.3 4.12e-7 Systemic lupus erythematosus; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00173170 chr1:214779122 CENPF -0.44 -6.1 -0.35 3.73e-9 Gut microbiota (bacterial taxa); CESC cis rs2276314 0.802 rs9963714 chr18:33592056 T/C cg05985134 chr18:33552581 C18orf21 0.61 7.12 0.4 1.01e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs36051895 0.623 rs7859361 chr9:5237479 C/T cg02405213 chr9:5042618 JAK2 -0.56 -6.62 -0.38 1.94e-10 Pediatric autoimmune diseases; CESC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg03526776 chr6:41159608 TREML2 -0.39 -6.92 -0.39 3.32e-11 Alzheimer's disease (late onset); CESC cis rs8180040 0.764 rs2132173 chr3:47247060 C/T cg27129171 chr3:47204927 SETD2 -0.47 -6.62 -0.38 2.03e-10 Colorectal cancer; CESC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4975709 0.959 rs9312959 chr5:1877008 G/A cg17650747 chr5:1873721 NA 0.38 5.15 0.3 5.03e-7 Cardiovascular disease risk factors; CESC cis rs2282802 0.685 rs6580515 chr5:139698110 A/C cg26211634 chr5:139558579 C5orf32 -0.45 -6.43 -0.37 6e-10 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09920427 chr19:12777674 MORG1;MAN2B1 -0.46 -6.72 -0.38 1.12e-10 Gambling; CESC trans rs1814175 0.669 rs11040455 chr11:49669829 G/C cg03929089 chr4:120376271 NA -0.73 -9.61 -0.51 5.76e-19 Height; CESC cis rs6987853 0.761 rs2974356 chr8:42434633 C/T cg09913449 chr8:42400586 C8orf40 0.46 7.65 0.43 3.68e-13 Mean corpuscular hemoglobin concentration; CESC cis rs2276314 0.857 rs62101394 chr18:33592299 C/T cg05985134 chr18:33552581 C18orf21 0.61 7.33 0.41 2.8e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs3026445 0.926 rs28609096 chr12:110815922 A/G cg12870014 chr12:110450643 ANKRD13A 0.42 5.2 0.3 4.07e-7 QT interval; CESC cis rs2732480 0.500 rs12829841 chr12:48628739 A/G cg24011408 chr12:48396354 COL2A1 0.43 5.9 0.34 1.11e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.08 19.95 0.77 1.03e-54 Prudent dietary pattern; CESC cis rs9309473 1.000 rs13421462 chr2:73719875 A/C cg20560298 chr2:73613845 ALMS1 -0.54 -7.05 -0.4 1.53e-11 Metabolite levels; CESC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg03351412 chr1:154909251 PMVK 0.57 7.06 0.4 1.46e-11 Prostate cancer; CESC cis rs1707322 0.686 rs2991986 chr1:46081282 A/G cg05343316 chr1:45956843 TESK2 -0.52 -6.36 -0.36 8.62e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9858542 0.953 rs9811982 chr3:49624377 A/C cg03060546 chr3:49711283 APEH -0.52 -6.14 -0.35 3.03e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9649465 1.000 rs3807640 chr7:123338713 G/C cg04330084 chr7:123175371 IQUB -0.39 -5.26 -0.31 2.95e-7 Migraine; CESC cis rs2832191 0.671 rs2832212 chr21:30511417 G/A cg24692254 chr21:30365293 RNF160 -0.61 -7.69 -0.43 2.86e-13 Dental caries; CESC cis rs787274 0.543 rs1041086 chr9:115627744 C/G cg13803584 chr9:115635662 SNX30 -0.66 -6.1 -0.35 3.77e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs826838 1.000 rs11183214 chr12:38692938 C/T cg26384229 chr12:38710491 ALG10B 0.83 15.17 0.68 7.62e-38 Heart rate; CESC cis rs3736485 0.966 rs4775944 chr15:51775610 T/C cg08986416 chr15:51914746 DMXL2 -0.42 -5.54 -0.32 7.22e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg24562669 chr7:97807699 LMTK2 0.48 7.1 0.4 1.13e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs7264396 0.635 rs6060660 chr20:34476649 T/C cg17201900 chr20:34330562 RBM39 0.5 5.09 0.3 6.68e-7 Total cholesterol levels; CESC cis rs2635047 0.967 rs2571016 chr18:44639175 C/G cg19077165 chr18:44547161 KATNAL2 0.47 6.38 0.36 7.86e-10 Educational attainment; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg13577407 chr3:57994372 FLNB 0.48 6.08 0.35 4.22e-9 Breast cancer;Type 2 diabetes; CESC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg11890956 chr21:40555474 PSMG1 0.64 8.97 0.48 5.72e-17 Menarche (age at onset); CESC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg04944784 chr2:26401820 FAM59B 0.96 10.55 0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs950027 0.620 rs1346267 chr15:45690989 A/G cg21132104 chr15:45694354 SPATA5L1 0.67 8.74 0.47 2.81e-16 Response to fenofibrate (adiponectin levels); CESC cis rs262147 0.610 rs2657363 chr7:158684273 C/T cg24397884 chr7:158709396 WDR60 0.68 5.16 0.3 4.85e-7 Hippocampal volume; CESC cis rs2637266 0.703 rs1345043 chr10:78458824 G/T cg18941641 chr10:78392320 NA 0.37 6.53 0.37 3.31e-10 Pulmonary function; CESC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg04772025 chr11:68637568 NA 0.57 6.63 0.38 1.87e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23979971 chr5:138677953 PAIP2 -0.47 -6.06 -0.35 4.67e-9 Ulcerative colitis; CESC cis rs939574 0.790 rs72955440 chr2:220091765 A/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.88 7.38 0.41 2e-12 Platelet distribution width; CESC cis rs7188697 0.922 rs11862156 chr16:58596753 C/T cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs4595586 0.545 rs12819907 chr12:39356906 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.63 0.42 4.31e-13 Morning vs. evening chronotype; CESC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg22903471 chr2:27725779 GCKR -0.5 -7.04 -0.4 1.66e-11 Total body bone mineral density; CESC cis rs11471957 1 rs11471957 chr20:57598332 C/CAA cg14073986 chr20:57617431 SLMO2 0.62 6.07 0.35 4.49e-9 Platelet count;Mean platelet volume; CESC cis rs10883723 0.773 rs715439 chr10:104257809 A/C cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7580658 0.521 rs35577992 chr2:127941324 C/T cg10021288 chr2:128175891 PROC -0.33 -5.07 -0.3 7.32e-7 Protein C levels; CESC trans rs2727020 0.894 rs1880438 chr11:49370698 A/G cg03929089 chr4:120376271 NA -0.65 -7.61 -0.42 4.95e-13 Coronary artery disease; CESC cis rs920590 0.721 rs67989257 chr8:19660278 G/A cg01411142 chr8:19674711 INTS10 0.53 5.89 0.34 1.14e-8 Acute lymphoblastic leukemia (childhood); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg17076397 chr5:10353763 MARCH6 0.49 6.57 0.37 2.7e-10 Breast cancer;Type 2 diabetes; CESC cis rs709400 0.628 rs4906321 chr14:103878882 C/T cg12935359 chr14:103987150 CKB -0.49 -7.3 -0.41 3.29e-12 Body mass index; CESC cis rs7560272 0.538 rs12233112 chr2:73931764 G/A cg20560298 chr2:73613845 ALMS1 0.47 6.36 0.36 8.73e-10 Schizophrenia; CESC cis rs7122539 0.646 rs594313 chr11:66608991 A/G cg24851651 chr11:66362959 CCS 0.46 6.56 0.37 2.77e-10 HIV-1 susceptibility; CESC trans rs7246760 0.867 rs57999229 chr19:9817357 C/T cg02900749 chr2:68251473 NA -0.86 -7.65 -0.43 3.79e-13 Pursuit maintenance gain; CESC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg04287289 chr16:89883240 FANCA -0.62 -8.69 -0.47 3.92e-16 Vitiligo; CESC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg04267008 chr7:1944627 MAD1L1 -0.5 -5.89 -0.34 1.19e-8 Schizophrenia; CESC cis rs9640161 0.750 rs11538922 chr7:150035183 C/T cg17279839 chr7:150038598 RARRES2 0.45 5.34 0.31 2e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs7264396 0.943 rs6060448 chr20:34112192 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.52 6.58 0.37 2.5e-10 Total cholesterol levels; CESC cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg12412775 chr1:25698385 RHCE -0.3 -5.3 -0.31 2.39e-7 Erythrocyte sedimentation rate; CESC cis rs6500395 1.000 rs1224 chr16:48572817 G/A cg04672837 chr16:48644449 N4BP1 0.5 6.21 0.36 2.04e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1577917 0.727 rs2758840 chr6:86304625 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -7.8 -0.43 1.46e-13 Response to antipsychotic treatment; CESC cis rs7828089 0.582 rs13259873 chr8:22266292 C/T cg23129673 chr8:22266227 SLC39A14 0.37 5.47 0.32 1.03e-7 Verbal declarative memory; CESC cis rs892961 0.932 rs7216155 chr17:75405155 C/G cg05865280 chr17:75406074 SEPT9 0.59 10.95 0.56 2.82e-23 Airflow obstruction; CESC cis rs7851660 0.548 rs1156850 chr9:100573164 G/A cg13688889 chr9:100608707 NA -0.9 -14.89 -0.67 7.55e-37 Strep throat; CESC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg11644478 chr21:40555479 PSMG1 0.99 15.22 0.68 5.25e-38 Cognitive function; CESC trans rs10435719 0.780 rs9692662 chr8:11789863 C/T cg15556689 chr8:8085844 FLJ10661 0.52 6.48 0.37 4.4e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs763121 0.853 rs9610993 chr22:39042818 C/A cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC cis rs17655565 0.581 rs1791626 chr12:52759979 T/C cg00777198 chr12:52828273 KRT75 0.35 5.09 0.3 6.8e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg14156121 chr10:33948478 NA -0.43 -6.34 -0.36 1.01e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6493487 0.512 rs7170009 chr15:51323648 C/A cg02338191 chr15:51200825 AP4E1 0.58 5.42 0.32 1.34e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4835473 0.801 rs35839125 chr4:144713504 C/A cg25736465 chr4:144833511 NA -0.35 -5.83 -0.34 1.59e-8 Immature fraction of reticulocytes; CESC cis rs9811920 0.809 rs6806323 chr3:99722564 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -7.82 -0.43 1.23e-13 Axial length; CESC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg06481639 chr22:41940642 POLR3H -0.63 -6.6 -0.38 2.22e-10 Vitiligo; CESC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.84 8.31 0.45 4.88e-15 Platelet count; CESC cis rs7692995 0.841 rs6449349 chr4:17952609 C/G cg08925142 chr4:18023851 LCORL -0.45 -5.26 -0.31 2.97e-7 Height; CESC cis rs7917772 0.503 rs11191330 chr10:104306160 G/T cg22532475 chr10:104410764 TRIM8 -0.33 -5.74 -0.33 2.65e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg06028808 chr11:68637592 NA 0.43 5.18 0.3 4.36e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13082711 0.871 rs73046194 chr3:27454558 C/T cg02860705 chr3:27208620 NA 0.54 7.0 0.39 2.13e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs7208859 0.623 rs2035494 chr17:29130393 T/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10129255 0.556 rs6576224 chr14:107186236 G/A cg07958169 chr14:107095056 NA -0.54 -8.51 -0.46 1.3e-15 Kawasaki disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20252016 chr11:64851499 CDCA5;ZFPL1 -0.4 -6.27 -0.36 1.49e-9 Gambling; CESC cis rs8020095 0.528 rs8003327 chr14:67855598 C/G cg19548862 chr14:67692701 FAM71D -0.45 -5.26 -0.31 2.98e-7 Depression (quantitative trait); CESC cis rs7178909 0.797 rs1910586 chr15:90440489 T/G cg19708238 chr15:90437601 AP3S2 0.46 6.52 0.37 3.52e-10 Common traits (Other); CESC cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg14416269 chr4:6271139 WFS1 0.46 7.73 0.43 2.23e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1003719 0.762 rs9975361 chr21:38450025 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.64 0.47 5.56e-16 Eye color traits; CESC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.4 -0.41 1.8e-12 Total body bone mineral density; CESC cis rs4648845 0.777 rs2477689 chr1:2395538 G/C cg13556452 chr1:2391241 NA -0.34 -5.64 -0.33 4.45e-8 Schizophrenia; CESC cis rs7592578 0.882 rs58568707 chr2:191468987 G/A cg27211696 chr2:191398769 TMEM194B -0.62 -5.67 -0.33 3.64e-8 Diastolic blood pressure; CESC cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg06544989 chr22:39130855 UNC84B 0.51 8.92 0.48 7.61e-17 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20979926 chr12:112546623 NAA25 0.66 7.33 0.41 2.74e-12 Gut microbiome composition (summer); CESC cis rs2295499 0.673 rs55688738 chr4:2704628 G/C cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.13 -0.3 5.58e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs11722228 0.521 rs56403947 chr4:10112529 T/G cg26043149 chr18:55253948 FECH 0.99 11.82 0.59 3.63e-26 Gout;Urate levels;Serum uric acid levels; CESC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.9e-10 Bipolar disorder; CESC cis rs854765 0.583 rs8065970 chr17:17858771 A/G cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC trans rs3780486 0.846 rs6476402 chr9:33148552 G/A cg04842962 chr6:43655489 MRPS18A 0.96 17.48 0.73 4.82e-46 IgG glycosylation; CESC cis rs75477785 0.590 rs17015566 chr1:210244865 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.23 0.36 1.82e-9 Cleft lip with or without cleft palate; CESC cis rs2050392 0.630 rs303426 chr10:30740379 A/G cg18806716 chr10:30721971 MAP3K8 0.39 5.8 0.34 1.89e-8 Inflammatory bowel disease; CESC cis rs9788721 0.592 rs28564957 chr15:78906107 C/A cg24631222 chr15:78858424 CHRNA5 0.43 5.46 0.32 1.08e-7 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CESC cis rs2439831 0.867 rs689616 chr15:43761901 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.58 0.54 4.72e-22 Lung cancer in ever smokers; CESC cis rs11122272 0.735 rs2790892 chr1:231512771 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.8 -0.43 1.41e-13 Hemoglobin concentration; CESC cis rs11122272 0.705 rs2790879 chr1:231534389 A/C cg06096015 chr1:231504339 EGLN1 0.38 5.29 0.31 2.54e-7 Hemoglobin concentration; CESC cis rs116095464 0.558 rs1971229 chr5:268187 A/G cg22857025 chr5:266934 NA -1.3 -18.55 -0.75 8.05e-50 Breast cancer; CESC cis rs7605827 0.704 rs62120513 chr2:15537727 T/A cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs17826219 0.500 rs57005940 chr17:29066329 C/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Body mass index; CESC cis rs7937682 0.883 rs553632 chr11:111462897 C/T cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC cis rs79387448 0.576 rs11902044 chr2:102972534 C/T cg09003973 chr2:102972529 NA 1.2 9.29 0.5 6.03e-18 Gut microbiota (bacterial taxa); CESC cis rs6424115 0.830 rs2502999 chr1:24198321 A/G cg10978503 chr1:24200527 CNR2 0.34 6.72 0.38 1.11e-10 Immature fraction of reticulocytes; CESC cis rs4810479 0.513 rs3746506 chr20:44586036 G/A cg17986701 chr20:44574422 PCIF1 0.33 5.05 0.3 8.38e-7 Metabolite levels; CESC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs3796619 0.924 rs11940546 chr4:1072485 C/T cg27284194 chr4:1044797 NA 0.37 5.53 0.32 7.53e-8 Recombination rate (males); CESC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.1 -0.35 3.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9300255 0.568 rs3018098 chr12:123654812 T/C cg05973401 chr12:123451056 ABCB9 0.5 5.7 0.33 3.19e-8 Neutrophil percentage of white cells; CESC cis rs72781680 0.821 rs2339887 chr2:24198376 G/A cg08917208 chr2:24149416 ATAD2B 0.66 6.5 0.37 3.98e-10 Lymphocyte counts; CESC cis rs858239 0.669 rs6461688 chr7:23116615 G/A cg23682824 chr7:23144976 KLHL7 0.46 6.12 0.35 3.35e-9 Cerebrospinal fluid biomarker levels; CESC trans rs7618501 0.815 rs3819325 chr3:49843723 T/C cg21659725 chr3:3221576 CRBN 0.83 13.22 0.63 5.57e-31 Intelligence (multi-trait analysis); CESC cis rs57506017 0.540 rs12699323 chr7:12253362 T/C cg23422036 chr7:12250390 TMEM106B 0.38 5.17 0.3 4.71e-7 Neuroticism; CESC cis rs2070677 0.866 rs2492664 chr10:135387240 G/T cg20169779 chr10:135381914 SYCE1 -0.75 -10.24 -0.53 5.91e-21 Gout; CESC cis rs75477785 0.590 rs760768 chr1:210177234 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.23 0.36 1.82e-9 Cleft lip with or without cleft palate; CESC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg26335602 chr6:28129616 ZNF389 0.53 7.09 0.4 1.19e-11 Parkinson's disease; CESC cis rs644148 0.967 rs2686778 chr19:44972257 G/A cg15540054 chr19:45004280 ZNF180 -0.72 -8.77 -0.47 2.23e-16 Personality dimensions; CESC cis rs1008375 1.000 rs4698649 chr4:17692782 A/G cg02297831 chr4:17616191 MED28 0.46 5.62 0.33 4.91e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs863345 0.504 rs2022386 chr1:158563076 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -5.58 -0.32 6.04e-8 Pneumococcal bacteremia; CESC cis rs3740713 1.000 rs73440637 chr11:18474128 C/A cg23797887 chr11:18477753 LDHAL6A -0.56 -5.18 -0.3 4.3e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs4727027 0.870 rs62507509 chr7:148795522 C/T cg23583168 chr7:148888333 NA -0.79 -12.1 -0.6 4.02e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs10979 1.000 rs11155300 chr6:143894576 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg04293180 chr8:144700367 TSTA3 0.49 6.62 0.38 2.03e-10 Tetralogy of Fallot; CESC cis rs75804782 0.521 rs56176151 chr2:239440220 T/C cg18131467 chr2:239335373 ASB1 -0.69 -5.5 -0.32 9.1e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs9811920 0.609 rs793465 chr3:99627750 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs881375 0.678 rs3761846 chr9:123689597 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.37 5.21 0.3 3.76e-7 Rheumatoid arthritis; CESC cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg13072238 chr3:49761600 GMPPB -0.51 -6.14 -0.35 3.03e-9 Menarche (age at onset); CESC trans rs2727020 0.595 rs11040416 chr11:49566429 C/T cg03929089 chr4:120376271 NA -0.85 -13.62 -0.64 2.23e-32 Coronary artery disease; CESC cis rs3774749 0.565 rs2188151 chr3:50201924 A/C cg24110177 chr3:50126178 RBM5 0.39 5.31 0.31 2.3e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.530 rs2865992 chr4:99067181 A/T cg05340658 chr4:99064831 C4orf37 0.59 7.96 0.44 5.16e-14 Colonoscopy-negative controls vs population controls; CESC cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg06713675 chr4:122721982 EXOSC9 -0.5 -6.82 -0.39 6.07e-11 Type 2 diabetes; CESC cis rs250677 0.687 rs1422581 chr5:148437386 C/T cg18129178 chr5:148520854 ABLIM3 0.48 5.53 0.32 7.54e-8 Breast cancer; CESC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg24675658 chr1:53192096 ZYG11B -0.61 -7.44 -0.42 1.42e-12 Monocyte count; CESC cis rs9361491 0.657 rs9341742 chr6:79440229 C/T cg05283184 chr6:79620031 NA -0.34 -5.1 -0.3 6.51e-7 Intelligence (multi-trait analysis); CESC cis rs2370759 1.000 rs11008865 chr10:32574842 C/T cg05361325 chr10:32636312 EPC1 -0.54 -5.12 -0.3 6e-7 Sexual dysfunction (female); CESC cis rs593982 1.000 rs1941746 chr11:65502413 A/G cg08755490 chr11:65554678 OVOL1 1.31 20.14 0.78 2.41e-55 Atopic dermatitis; CESC cis rs5758511 0.633 rs5758689 chr22:42664972 T/G cg00645731 chr22:42541494 CYP2D7P1 0.58 8.76 0.47 2.43e-16 Birth weight; CESC cis rs1568889 1.000 rs2354427 chr11:28049623 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.85 0.55 6.02e-23 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09301471 chr16:89349945 ANKRD11 -0.57 -6.84 -0.39 5.56e-11 Gut microbiome composition (summer); CESC cis rs6028335 0.674 rs3752301 chr20:37654024 T/G cg16355469 chr20:37678765 NA 0.54 5.28 0.31 2.74e-7 Alcohol and nicotine co-dependence; CESC cis rs34779708 0.931 rs2384287 chr10:35340559 A/G cg03585969 chr10:35415529 CREM 0.76 9.74 0.51 2.35e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg16325326 chr1:53192061 ZYG11B -0.91 -16.01 -0.7 8.25e-41 Monocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01184520 chr16:75032509 ZNRF1 0.38 6.14 0.35 2.94e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg04013166 chr16:89971882 TCF25 -0.67 -6.01 -0.35 6.22e-9 Skin colour saturation; CESC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg17971929 chr21:40555470 PSMG1 1.08 16.28 0.71 9.03e-42 Cognitive function; CESC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.83 8.24 0.45 7.99e-15 Platelet count; CESC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.87 9.14 0.49 1.7e-17 Platelet count; CESC cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg17366294 chr4:99064904 C4orf37 0.51 6.62 0.38 1.93e-10 Colonoscopy-negative controls vs population controls; CESC cis rs4481887 0.821 rs7515408 chr1:248425738 C/T cg00666640 chr1:248458726 OR2T12 0.41 6.69 0.38 1.32e-10 Common traits (Other); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26612252 chr16:48643305 N4BP1 -0.47 -6.6 -0.38 2.21e-10 Asthma; CESC cis rs4629710 0.592 rs9492877 chr6:131562577 C/G cg12606694 chr6:131520996 AKAP7 0.49 6.05 0.35 4.81e-9 Multiple myeloma (IgH translocation); CESC cis rs2197308 0.765 rs11182992 chr12:37935572 G/C cg13010199 chr12:38710504 ALG10B 0.53 6.77 0.38 8.4e-11 Morning vs. evening chronotype; CESC cis rs2637266 0.686 rs1660915 chr10:78525318 T/A cg18941641 chr10:78392320 NA 0.41 7.54 0.42 7.33e-13 Pulmonary function; CESC cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4604732 0.631 rs12031721 chr1:247623773 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.55 6.86 0.39 4.77e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6088580 0.524 rs6088568 chr20:33265971 A/C cg08999081 chr20:33150536 PIGU -0.45 -6.29 -0.36 1.33e-9 Glomerular filtration rate (creatinine); CESC cis rs1707322 1.000 rs4524994 chr1:46370263 A/G cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs863345 0.625 rs12063360 chr1:158499494 A/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs1538970 0.962 rs7544178 chr1:45819069 C/T cg03146154 chr1:46216737 IPP 0.45 5.38 0.31 1.62e-7 Platelet count; CESC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg18876405 chr7:65276391 NA -0.51 -6.73 -0.38 1.05e-10 Aortic root size; CESC cis rs4523957 0.559 rs170040 chr17:2165714 C/T cg16513277 chr17:2031491 SMG6 0.59 6.78 0.38 7.62e-11 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg20243544 chr17:37824526 PNMT -0.47 -5.97 -0.34 7.6e-9 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23332732 chr12:26986274 ITPR2 0.58 6.19 0.36 2.27e-9 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13894163 chr9:136932022 BRD3 0.42 6.06 0.35 4.72e-9 Systemic lupus erythematosus; CESC cis rs7296418 0.922 rs12425009 chr12:123502044 C/T cg05973401 chr12:123451056 ABCB9 0.58 7.62 0.42 4.54e-13 Platelet count; CESC trans rs7178375 1.000 rs7176351 chr15:31208727 G/A cg04373760 chr16:53404718 NA 0.58 7.71 0.43 2.54e-13 Hypertriglyceridemia; CESC cis rs10861342 1.000 rs12320123 chr12:105492167 C/T cg23923672 chr12:105501055 KIAA1033 0.65 5.29 0.31 2.52e-7 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11207852 chr1:91966655 CDC7 0.62 7.27 0.41 4.08e-12 Gut microbiome composition (summer); CESC cis rs11190604 1.000 rs7090431 chr10:102261753 A/G cg07080220 chr10:102295463 HIF1AN 0.66 6.48 0.37 4.45e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs853679 0.882 rs3757188 chr6:28107357 T/C cg23372001 chr6:27791640 HIST1H4J 0.57 5.18 0.3 4.48e-7 Depression; CESC cis rs68170813 0.559 rs77422419 chr7:106957932 A/G cg02696742 chr7:106810147 HBP1 -0.53 -5.03 -0.3 8.96e-7 Coronary artery disease; CESC cis rs790123 0.965 rs2133850 chr3:122381696 C/T cg17380795 chr3:122379686 NA 0.35 5.22 0.31 3.61e-7 Response to angiotensin II receptor blocker therapy; CESC trans rs116095464 0.558 rs10462755 chr5:246748 T/C cg00938859 chr5:1591904 SDHAP3 0.63 6.92 0.39 3.29e-11 Breast cancer; CESC cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg26818010 chr10:134567672 INPP5A -0.8 -9.85 -0.52 1.04e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs10242455 0.702 rs73713531 chr7:99222379 C/T cg24650262 chr7:98904301 NA 0.57 5.07 0.3 7.38e-7 Blood metabolite levels; CESC cis rs7786808 0.649 rs1377374 chr7:158215647 G/T cg09998033 chr7:158218633 PTPRN2 0.37 5.71 0.33 2.96e-8 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13987669 chr5:33440719 TARS 0.57 6.32 0.36 1.13e-9 Gut microbiome composition (summer); CESC cis rs6032067 0.641 rs74174932 chr20:43756133 G/A cg10761708 chr20:43804764 PI3 0.5 5.25 0.31 3.12e-7 Blood protein levels; CESC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg00310523 chr12:86230176 RASSF9 0.36 5.51 0.32 8.38e-8 Major depressive disorder; CESC cis rs9457247 0.663 rs9459839 chr6:167431829 T/C cg25258033 chr6:167368657 RNASET2 0.35 5.13 0.3 5.7e-7 Crohn's disease; CESC cis rs1878931 0.668 rs2074366 chr16:3439676 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 1.03 16.68 0.72 3.5e-43 Body mass index (adult); CESC cis rs921968 0.541 rs636723 chr2:219373197 A/G cg02176678 chr2:219576539 TTLL4 0.5 9.05 0.49 3.15e-17 Mean corpuscular hemoglobin concentration; CESC cis rs9303401 0.580 rs34076823 chr17:57114497 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.89 11.06 0.56 1.21e-23 Cognitive test performance; CESC cis rs9486715 0.867 rs9373887 chr6:96957004 C/T cg06623918 chr6:96969491 KIAA0776 0.92 14.08 0.65 5.46e-34 Headache; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg10150615 chr22:24372951 LOC391322 -0.48 -6.22 -0.36 1.94e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9811920 0.581 rs793468 chr3:99538346 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.5 -5.99 -0.35 6.71e-9 Axial length; CESC cis rs10423674 0.526 rs757317 chr19:18819984 C/T cg14292368 chr19:18793705 CRTC1 -0.46 -5.89 -0.34 1.14e-8 Menarche (age at onset); CESC cis rs2011503 0.941 rs4808934 chr19:19370917 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.53 0.32 7.55e-8 Bipolar disorder; CESC cis rs16854884 1.000 rs58251824 chr3:143786258 T/C cg06585982 chr3:143692056 C3orf58 0.46 5.65 0.33 4.2e-8 Economic and political preferences (feminism/equality); CESC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg04315214 chr1:2043799 PRKCZ 0.65 11.4 0.57 9.18e-25 Height; CESC cis rs977987 0.933 rs4888431 chr16:75500699 G/T cg03315344 chr16:75512273 CHST6 0.53 7.8 0.43 1.42e-13 Dupuytren's disease; CESC trans rs4906172 0.773 rs1190613 chr14:102521534 A/G cg17920195 chr4:129149383 NA 0.32 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs9549367 0.673 rs575453 chr13:113837871 C/A cg00898013 chr13:113819073 PROZ 0.47 6.89 0.39 3.97e-11 Platelet distribution width; CESC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.77 0.38 8.42e-11 Bipolar disorder; CESC cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg26597838 chr10:835615 NA 0.86 8.93 0.48 7.33e-17 Eosinophil percentage of granulocytes; CESC cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg20503657 chr10:835505 NA 0.71 6.72 0.38 1.12e-10 Eosinophil percentage of granulocytes; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg14757344 chr21:45209507 RRP1 0.48 6.5 0.37 3.88e-10 Systemic lupus erythematosus; CESC cis rs12422267 0.609 rs10128884 chr12:132621624 C/T cg09764611 chr12:132620959 NA -0.53 -7.15 -0.4 8.44e-12 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg04414720 chr1:150670196 GOLPH3L -0.45 -5.95 -0.34 8.38e-9 Melanoma; CESC cis rs7772486 0.790 rs2243665 chr6:146208120 A/C cg05347473 chr6:146136440 FBXO30 0.5 6.03 0.35 5.47e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs6987853 0.661 rs6988493 chr8:42351328 C/T cg09913449 chr8:42400586 C8orf40 -0.37 -6.01 -0.35 6.23e-9 Mean corpuscular hemoglobin concentration; CESC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg00149659 chr3:10157352 C3orf10 0.69 8.19 0.45 1.12e-14 Alzheimer's disease; CESC cis rs11098499 0.865 rs11722183 chr4:120280597 A/C cg24375607 chr4:120327624 NA 0.45 5.51 0.32 8.29e-8 Corneal astigmatism; CESC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6540556 0.723 rs11119327 chr1:209883804 T/C cg05527609 chr1:210001259 C1orf107 -0.69 -7.48 -0.42 1.08e-12 Red blood cell count; CESC cis rs13242816 1.000 rs987790 chr7:116134633 T/A cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC cis rs7408868 1.000 rs10420466 chr19:15261371 G/T cg14696996 chr19:15285081 NOTCH3 1.12 11.29 0.57 2.08e-24 Pulse pressure; CESC cis rs12313068 0.656 rs41436646 chr12:110495171 C/G cg12870014 chr12:110450643 ANKRD13A 0.83 9.43 0.5 2.1e-18 Intelligence (multi-trait analysis); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg09115837 chr10:79541592 NA 0.43 6.03 0.35 5.35e-9 Breast cancer; CESC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg06494592 chr3:125709126 NA -0.51 -5.44 -0.32 1.22e-7 Blood pressure (smoking interaction); CESC cis rs113835537 0.866 rs59566349 chr11:66365994 A/T cg24851651 chr11:66362959 CCS 0.63 5.6 0.33 5.28e-8 Airway imaging phenotypes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08642743 chr17:74099944 EXOC7 0.48 6.39 0.37 7.25e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05342987 chr14:59655273 DAAM1 -0.53 -6.84 -0.39 5.33e-11 Ulcerative colitis; CESC cis rs2012796 0.704 rs57670850 chr14:81841577 C/T cg02996355 chr14:81879375 NA 0.67 8.1 0.45 2.07e-14 Night sleep phenotypes; CESC cis rs7267979 1.000 rs6037095 chr20:25335687 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.48 -0.71 1.75e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs6831352 0.918 rs13110176 chr4:100062430 C/T cg13256891 chr4:100009986 ADH5 0.74 8.35 0.46 3.84e-15 Alcohol dependence; CESC cis rs597539 0.654 rs7107137 chr11:68623712 A/G cg04772025 chr11:68637568 NA 0.53 5.95 0.34 8.3e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9457247 0.534 rs1130033 chr6:167385623 C/T cg23791538 chr6:167370224 RNASET2 -0.72 -10.2 -0.53 7.92e-21 Crohn's disease; CESC cis rs854765 0.647 rs854814 chr17:18003648 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.05 0.35 4.92e-9 Total body bone mineral density; CESC cis rs5769765 0.773 rs7410291 chr22:50300078 A/G cg02269571 chr22:50332266 NA -0.49 -6.49 -0.37 4.14e-10 Schizophrenia; CESC cis rs8067354 0.574 rs1296279 chr17:57965731 G/A cg13753209 chr17:57696993 CLTC 0.55 5.84 0.34 1.49e-8 Hemoglobin concentration; CESC cis rs1797885 0.651 rs1552485 chr3:12580283 C/T cg26432171 chr3:12704882 RAF1 0.53 6.91 0.39 3.71e-11 Immature fraction of reticulocytes; CESC cis rs9900062 0.844 rs9908143 chr17:62754586 T/C cg02598441 chr17:62777298 LOC146880 -0.57 -5.62 -0.33 4.84e-8 QT interval; CESC cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg12463550 chr7:65579703 CRCP 0.69 5.37 0.31 1.74e-7 Diabetic kidney disease; CESC cis rs1005277 0.540 rs1987431 chr10:37988887 T/C cg25517755 chr10:38738941 LOC399744 -0.42 -5.42 -0.32 1.34e-7 Extrinsic epigenetic age acceleration; CESC cis rs933688 1.000 rs186717 chr5:90780467 T/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.03 13.27 0.63 3.59e-31 Smoking behavior; CESC trans rs7628583 0.660 rs11718458 chr3:64076420 T/C cg18893528 chr10:4296406 NA 0.46 6.01 0.35 5.98e-9 Parental extreme longevity (95 years and older); CESC cis rs8014204 0.935 rs2853779 chr14:75368508 G/A cg08847533 chr14:75593920 NEK9 -0.47 -5.79 -0.34 1.94e-8 Caffeine consumption; CESC cis rs34779708 0.931 rs34815241 chr10:35296676 T/C cg03585969 chr10:35415529 CREM 0.75 9.74 0.51 2.26e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs6582630 0.519 rs8189561 chr12:38296178 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs7208859 0.623 rs55961983 chr17:29119286 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1499614 1.000 rs2707838 chr7:66159201 C/T cg18252515 chr7:66147081 NA -1.42 -14.62 -0.67 6.69e-36 Gout; CESC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg07157834 chr1:205819609 PM20D1 0.45 6.56 0.37 2.88e-10 Menarche (age at onset); CESC cis rs79387448 0.638 rs11465698 chr2:103054577 T/C cg09003973 chr2:102972529 NA 0.94 7.25 0.41 4.66e-12 Gut microbiota (bacterial taxa); CESC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15153026 chr7:143058944 FAM131B 0.57 6.18 0.35 2.35e-9 Gut microbiome composition (summer); CESC cis rs8067545 0.750 rs4925080 chr17:19991838 T/A cg13482628 chr17:19912719 NA 0.4 5.33 0.31 2.12e-7 Schizophrenia; CESC cis rs10908458 0.743 rs7367207 chr1:155079477 C/T cg27045062 chr1:155054711 EFNA3 0.37 5.1 0.3 6.58e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs16922576 0.623 rs2093446 chr9:5230371 G/C cg02405213 chr9:5042618 JAK2 -0.58 -6.61 -0.38 2.05e-10 Allergic disease (asthma, hay fever or eczema); CESC cis rs73206853 0.841 rs56887341 chr12:110947185 T/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.59 0.32 5.78e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2286503 0.780 rs2286506 chr7:22854815 T/C cg11367502 chr7:22862612 TOMM7 0.39 5.14 0.3 5.45e-7 Fibrinogen; CESC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg06634786 chr22:41940651 POLR3H -0.73 -7.69 -0.43 2.96e-13 Vitiligo; CESC cis rs7587476 0.784 rs34112702 chr2:215696002 A/G cg04004882 chr2:215674386 BARD1 0.49 5.34 0.31 2.02e-7 Neuroblastoma; CESC trans rs61931739 0.517 rs10844727 chr12:34017435 C/T cg26384229 chr12:38710491 ALG10B 0.5 6.87 0.39 4.63e-11 Morning vs. evening chronotype; CESC trans rs61931739 0.517 rs10844815 chr12:34245150 G/A cg26384229 chr12:38710491 ALG10B 0.63 9.14 0.49 1.66e-17 Morning vs. evening chronotype; CESC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Depression; CESC trans rs7615952 0.599 rs60847438 chr3:125746005 T/C cg07211511 chr3:129823064 LOC729375 -0.6 -6.66 -0.38 1.62e-10 Blood pressure (smoking interaction); CESC cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg11764359 chr7:65958608 NA 0.82 9.29 0.5 6.03e-18 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18235443 chr1:150980829 FAM63A;PRUNE 0.59 6.64 0.38 1.82e-10 Gut microbiome composition (summer); CESC cis rs6598955 0.724 rs4659420 chr1:26614333 G/A cg00852783 chr1:26633632 UBXN11 0.42 6.23 0.36 1.79e-9 Obesity-related traits; CESC cis rs9911578 1.000 rs11869828 chr17:56609525 G/A cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.5e-11 Intelligence (multi-trait analysis); CESC cis rs7602441 0.521 rs74742552 chr2:14773375 G/T cg06545361 chr2:14773388 FAM84A 0.68 6.34 0.36 1.01e-9 Visceral adipose tissue adjusted for BMI; CESC trans rs561341 1.000 rs483301 chr17:30293398 G/T cg20587970 chr11:113659929 NA -1.48 -19.48 -0.77 4.55e-53 Hip circumference adjusted for BMI; CESC cis rs61784830 0.710 rs61783196 chr1:46291790 C/T cg03146154 chr1:46216737 IPP 0.69 5.59 0.33 5.51e-8 Iron status biomarkers (total iron binding capacity); CESC cis rs7605827 0.930 rs13030859 chr2:15701038 G/A cg19274914 chr2:15703543 NA 0.3 5.34 0.31 2.03e-7 Educational attainment (years of education); CESC cis rs6912958 0.781 rs1051148 chr6:88221892 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.73 -0.38 1.06e-10 Monocyte percentage of white cells; CESC cis rs7089973 0.604 rs11196932 chr10:116584386 C/T cg23260525 chr10:116636907 FAM160B1 0.38 6.86 0.39 4.82e-11 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg21926612 chr6:163149169 PACRG;PARK2 1.07 11.07 0.56 1.14e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11412256 chr1:228612818 HIST3H3 -0.67 -7.57 -0.42 6.2800000000000005e-13 Gut microbiome composition (summer); CESC cis rs2425143 0.841 rs4911519 chr20:34362326 A/T cg04508476 chr20:34239394 CPNE1;RBM12 0.8 7.75 0.43 1.96e-13 Blood protein levels; CESC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg09359103 chr1:154839909 KCNN3 -0.67 -12.43 -0.61 2.92e-28 Prostate cancer; CESC cis rs9611565 0.694 rs202613 chr22:41821993 C/A cg17376030 chr22:41985996 PMM1 -0.76 -8.01 -0.44 3.71e-14 Vitiligo; CESC cis rs3820928 0.874 rs10177995 chr2:227781600 T/C cg05526886 chr2:227700861 RHBDD1 -0.46 -5.89 -0.34 1.16e-8 Pulmonary function; CESC cis rs17253792 0.822 rs28409547 chr14:56047826 C/T cg01858014 chr14:56050164 KTN1 -0.96 -7.65 -0.43 3.84e-13 Putamen volume; CESC cis rs7659604 0.521 rs13130789 chr4:122690166 G/A cg19671926 chr4:122722719 EXOSC9 0.65 8.55 0.46 1e-15 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09345431 chr20:47538576 ARFGEF2 0.59 6.5 0.37 4.08e-10 Gut microbiome composition (summer); CESC cis rs5758659 0.714 rs6002607 chr22:42496506 C/T cg04733989 chr22:42467013 NAGA -0.41 -5.59 -0.32 5.62e-8 Cognitive function; CESC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg25405998 chr7:65216604 CCT6P1 -0.5 -6.4 -0.37 7.05e-10 Calcium levels; CESC cis rs2996428 0.561 rs2275833 chr1:3745721 C/T cg10555106 chr1:3691387 LOC388588 0.37 5.26 0.31 2.94e-7 Red cell distribution width; CESC cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.12 0.3 5.85e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 1.000 rs7694020 chr4:17682597 C/T cg02297831 chr4:17616191 MED28 0.43 5.44 0.32 1.23e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1568889 0.730 rs6484350 chr11:28113658 G/A cg06544937 chr11:28130018 METT5D1;KIF18A -0.8 -13.53 -0.64 4.71e-32 Bipolar disorder; CESC cis rs3091242 0.933 rs35403885 chr1:25784551 G/A cg03538708 chr1:25844672 NA 0.39 5.96 0.34 7.98e-9 Erythrocyte sedimentation rate; CESC cis rs4253772 0.591 rs6007732 chr22:46652303 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.68 8.04 0.44 3.03e-14 LDL cholesterol;Cholesterol, total; CESC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.51 0.37 3.72e-10 Prudent dietary pattern; CESC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg12963246 chr6:28129442 ZNF389 0.57 7.67 0.43 3.36e-13 Depression; CESC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg11890956 chr21:40555474 PSMG1 1.15 22.29 0.81 1.04e-62 Cognitive function; CESC cis rs7542091 0.635 rs985431 chr1:210043948 A/T cg23283495 chr1:209979779 IRF6 0.35 5.8 0.34 1.84e-8 Monobrow; CESC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg08499158 chr17:42289980 UBTF -0.47 -5.74 -0.33 2.53e-8 Total body bone mineral density; CESC cis rs453301 0.606 rs7462373 chr8:8899318 G/C cg15556689 chr8:8085844 FLJ10661 -0.5 -6.18 -0.36 2.36e-9 Joint mobility (Beighton score); CESC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg19592336 chr6:28129416 ZNF389 0.62 8.12 0.45 1.77e-14 Depression; CESC cis rs1801251 1.000 rs2674839 chr2:233669040 G/C cg25237894 chr2:233734115 C2orf82 0.47 8.27 0.45 6.45e-15 Coronary artery disease; CESC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg22535103 chr8:58192502 C8orf71 -1.03 -13.48 -0.64 7.04e-32 Developmental language disorder (linguistic errors); CESC cis rs708547 0.874 rs73242624 chr4:57847420 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 7.47 0.42 1.15e-12 Response to bleomycin (chromatid breaks); CESC cis rs9911578 1.000 rs4372750 chr17:57013803 A/C cg05425664 chr17:57184151 TRIM37 0.5 6.86 0.39 4.94e-11 Intelligence (multi-trait analysis); CESC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg24578937 chr1:2090814 PRKCZ -0.35 -5.91 -0.34 1.06e-8 Height; CESC cis rs9486719 1.000 rs6921291 chr6:97066242 C/T cg06623918 chr6:96969491 KIAA0776 -0.79 -8.12 -0.45 1.75e-14 Migraine;Coronary artery disease; CESC cis rs4589502 0.925 rs57729347 chr15:67136438 G/A cg12317470 chr15:67143691 NA 0.8 9.37 0.5 3.23e-18 Lung cancer (smoking interaction); CESC cis rs7584330 0.744 rs10929235 chr2:238380272 A/G cg14458575 chr2:238380390 NA 0.9 12.63 0.61 5.85e-29 Prostate cancer; CESC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg06481639 chr22:41940642 POLR3H 0.62 6.22 0.36 1.88e-9 Vitiligo; CESC cis rs3768617 0.510 rs2027076 chr1:183073407 C/A ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.05e-34 Fuchs's corneal dystrophy; CESC cis rs10751667 0.961 rs6597971 chr11:928598 T/A cg06064525 chr11:970664 AP2A2 -0.43 -7.7 -0.43 2.72e-13 Alzheimer's disease (late onset); CESC cis rs9486719 0.895 rs11152960 chr6:96900398 A/G cg18709589 chr6:96969512 KIAA0776 -0.54 -5.87 -0.34 1.3e-8 Migraine;Coronary artery disease; CESC trans rs11039798 0.588 rs7479642 chr11:48553808 G/T cg03929089 chr4:120376271 NA 0.62 6.09 0.35 4.05e-9 Axial length; CESC cis rs1008375 0.966 rs2315645 chr4:17579678 G/C cg02297831 chr4:17616191 MED28 0.5 6.03 0.35 5.44e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9715521 0.557 rs13146381 chr4:59853842 T/C cg11281224 chr4:60001000 NA -0.4 -5.46 -0.32 1.09e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg18337363 chr3:52569053 NT5DC2 0.32 6.09 0.35 3.87e-9 Electroencephalogram traits; CESC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.93 10.32 0.54 3.22e-21 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19368966 chr1:10458856 PGD 0.58 6.5 0.37 3.98e-10 Gut microbiome composition (summer); CESC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs11688816 0.569 rs7591708 chr2:63022050 T/C cg17519650 chr2:63277830 OTX1 -0.64 -8.78 -0.47 2.04e-16 Body mass index; CESC cis rs7998202 0.614 rs423117 chr13:113346107 C/T cg02820901 chr13:113351484 ATP11A -0.54 -5.22 -0.31 3.65e-7 Glycated hemoglobin levels; CESC cis rs977987 0.806 rs12924920 chr16:75440133 G/A cg03315344 chr16:75512273 CHST6 0.41 5.86 0.34 1.35e-8 Dupuytren's disease; CESC cis rs7855088 1.000 rs7855088 chr9:100742253 C/T cg13688889 chr9:100608707 NA -0.37 -5.61 -0.33 4.98e-8 Serum thyroid-stimulating hormone levels; CESC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg26338869 chr17:61819248 STRADA 0.67 8.77 0.47 2.24e-16 Prudent dietary pattern; CESC cis rs2898681 0.561 rs7699960 chr4:53735661 C/A cg00791764 chr4:53727839 RASL11B 0.44 5.16 0.3 4.96e-7 Optic nerve measurement (cup area); CESC cis rs72634258 0.554 rs17374781 chr1:7919363 A/G cg00042356 chr1:8021962 PARK7 -0.57 -5.42 -0.32 1.31e-7 Inflammatory bowel disease; CESC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg24675658 chr1:53192096 ZYG11B 0.54 7.53 0.42 7.86e-13 Monocyte count; CESC cis rs524023 0.874 rs518053 chr11:64456099 C/T cg19131476 chr11:64387923 NRXN2 -0.33 -5.05 -0.3 8.13e-7 Urate levels in obese individuals; CESC trans rs7395662 0.534 rs12418219 chr11:48988091 G/T cg15704280 chr7:45808275 SEPT13 -0.55 -6.66 -0.38 1.62e-10 HDL cholesterol; CESC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg21782813 chr7:2030301 MAD1L1 0.35 5.12 0.3 6.02e-7 Bipolar disorder and schizophrenia; CESC cis rs9291683 0.509 rs998676 chr4:9948564 T/C cg00071950 chr4:10020882 SLC2A9 -0.79 -14.72 -0.67 3.02e-36 Bone mineral density; CESC cis rs16867321 0.694 rs4666853 chr2:181439671 C/T cg23363182 chr2:181467187 NA 0.49 7.2 0.4 6.07e-12 Obesity; CESC cis rs854765 0.547 rs2955380 chr17:17944349 A/G cg09796270 chr17:17721594 SREBF1 -0.38 -5.07 -0.3 7.66e-7 Total body bone mineral density; CESC cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg08822215 chr16:89438651 ANKRD11 -0.42 -6.44 -0.37 5.7e-10 Multiple myeloma (IgH translocation); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02769252 chr17:25932535 KSR1 0.43 6.17 0.35 2.5e-9 Fibrinogen levels; CESC cis rs2380220 0.810 rs877096 chr6:95937046 A/G cg15832292 chr6:96025679 MANEA -0.64 -5.71 -0.33 2.99e-8 Behavioural disinhibition (generation interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26256999 chr1:249200418 PGBD2 0.63 7.09 0.4 1.19e-11 Gut microbiome composition (summer); CESC cis rs4523957 0.890 rs12941621 chr17:2194852 C/T cg16513277 chr17:2031491 SMG6 0.56 7.41 0.41 1.68e-12 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg13147721 chr7:65941812 NA 0.37 5.04 0.3 8.48e-7 Aortic root size; CESC cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg17724175 chr1:150552817 MCL1 -0.34 -5.44 -0.32 1.24e-7 Tonsillectomy; CESC cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg21138405 chr5:131827807 IRF1 -0.6 -10.61 -0.55 3.84e-22 Asthma (sex interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19522900 chr3:124303745 KALRN 0.45 5.99 0.35 6.63e-9 Gut microbiota (bacterial taxa); CESC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg23758822 chr17:41437982 NA 1.02 15.55 0.69 3.45e-39 Menopause (age at onset); CESC cis rs3736485 0.966 rs11070852 chr15:51782294 G/T cg08986416 chr15:51914746 DMXL2 -0.41 -5.21 -0.3 3.77e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13327952 chr7:90032561 CLDN12 -0.52 -6.03 -0.35 5.56e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg21724239 chr8:58056113 NA 0.52 5.36 0.31 1.78e-7 Developmental language disorder (linguistic errors); CESC cis rs963731 0.649 rs297153 chr2:39326835 C/G cg04010122 chr2:39346883 SOS1 -0.75 -5.58 -0.32 6.05e-8 Corticobasal degeneration; CESC cis rs7223966 0.515 rs2727315 chr17:61961458 C/T cg25324976 chr17:61989376 CSHL1 0.41 5.79 0.34 1.99e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg15369054 chr17:80825471 TBCD 0.56 7.77 0.43 1.68e-13 Breast cancer; CESC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg05564831 chr3:52568323 NT5DC2 0.46 7.15 0.4 8.7e-12 Bipolar disorder; CESC cis rs7927771 0.524 rs12226431 chr11:47805856 G/A cg20307385 chr11:47447363 PSMC3 0.61 8.5 0.46 1.36e-15 Subjective well-being; CESC cis rs7927771 0.965 rs3817335 chr11:47643891 T/A cg05585544 chr11:47624801 NA -0.54 -8.5 -0.46 1.37e-15 Subjective well-being; CESC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg20151795 chr6:28129481 ZNF389 0.44 5.74 0.33 2.6e-8 Parkinson's disease; CESC cis rs433852 0.718 rs550455 chr19:49136515 A/G cg06530960 chr19:49140787 SEC1;DBP -0.42 -5.15 -0.3 5.1e-7 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; CESC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg08392591 chr16:89556376 ANKRD11 0.57 7.81 0.43 1.36e-13 Multiple myeloma (IgH translocation); CESC cis rs748404 0.587 rs9920879 chr15:43639770 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.81 0.43 1.33e-13 Lung cancer; CESC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg02018176 chr4:1364513 KIAA1530 0.6 7.52 0.42 8.35e-13 Longevity; CESC cis rs9291683 0.530 rs13115193 chr4:9982191 C/T cg11266682 chr4:10021025 SLC2A9 0.62 12.69 0.61 3.76e-29 Bone mineral density; CESC cis rs2832191 0.791 rs7282843 chr21:30475226 A/G cg24692254 chr21:30365293 RNF160 0.8 12.54 0.61 1.25e-28 Dental caries; CESC cis rs2857078 0.654 rs9896789 chr17:42314567 C/T cg13607699 chr17:42295918 UBTF 0.84 12.25 0.6 1.27e-27 Red cell distribution width;Reticulocyte count; CESC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg13206674 chr6:150067644 NUP43 0.4 5.45 0.32 1.18e-7 Lung cancer; CESC cis rs9837602 1.000 rs9833888 chr3:99723580 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.51 0.42 9.05e-13 Breast cancer; CESC cis rs1879734 0.731 rs6658245 chr1:54159005 T/C cg23596471 chr1:54105337 GLIS1 0.35 5.67 0.33 3.77e-8 Mitral valve prolapse; CESC cis rs6714710 0.663 rs71429376 chr2:98534412 T/C cg26665480 chr2:98280029 ACTR1B 0.53 7.31 0.41 3.07e-12 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs2249625 0.523 rs2496554 chr6:72855840 A/T cg18830697 chr6:72922368 RIMS1 -0.42 -6.14 -0.35 3.01e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26944263 chr12:93964231 SOCS2 0.66 7.23 0.41 5.12e-12 Gut microbiome composition (summer); CESC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg00908189 chr16:619842 PIGQ 0.64 9.15 0.49 1.61e-17 Height; CESC cis rs9486719 1.000 rs6923212 chr6:97061940 A/G cg18709589 chr6:96969512 KIAA0776 -0.54 -6.0 -0.35 6.46e-9 Migraine;Coronary artery disease; CESC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg11764359 chr7:65958608 NA -0.78 -11.24 -0.57 3.14e-24 Aortic root size; CESC cis rs72634258 0.503 rs72632055 chr1:7835774 T/G cg26816564 chr1:7831052 VAMP3 0.7 6.42 0.37 6.33e-10 Inflammatory bowel disease; CESC cis rs2742417 0.603 rs7631818 chr3:45775931 A/T cg04837898 chr3:45731254 SACM1L -0.46 -6.11 -0.35 3.5e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.87 -12.19 -0.6 1.98e-27 Prudent dietary pattern; CESC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.71 -0.33 2.98e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7607369 0.714 rs2272190 chr2:219609995 G/C cg02176678 chr2:219576539 TTLL4 -0.46 -8.23 -0.45 8.59e-15 Red blood cell count;Amyotrophic lateral sclerosis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04359004 chr20:61427998 C20orf20 -0.43 -6.31 -0.36 1.15e-9 Gambling; CESC cis rs13223928 0.621 rs4722438 chr7:3155813 A/G cg19214707 chr7:3157722 NA 0.42 5.8 0.34 1.85e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs614226 1.000 rs614226 chr12:120974510 C/T cg01236616 chr12:121019343 POP5 -1.55 -19.24 -0.76 3.12e-52 Type 1 diabetes nephropathy; CESC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg26944245 chr16:421049 TMEM8A;MRPL28 0.43 6.5 0.37 3.9e-10 Bone mineral density (spine);Bone mineral density; CESC cis rs8114671 0.836 rs3746432 chr20:33592763 C/T cg06115741 chr20:33292138 TP53INP2 -0.44 -5.23 -0.31 3.37e-7 Height; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg21177064 chr12:4410167 CCND2 0.45 6.01 0.35 6.24e-9 Subjective well-being; CESC cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.66 0.33 4e-8 Tonsillectomy; CESC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg09365446 chr1:150670422 GOLPH3L 0.37 5.18 0.3 4.49e-7 Tonsillectomy; CESC cis rs11864453 0.578 rs2072141 chr16:72133211 G/A cg16558253 chr16:72132732 DHX38 -0.54 -8.47 -0.46 1.7e-15 Fibrinogen levels; CESC cis rs7267979 1.000 rs6083844 chr20:25386832 C/T cg08601574 chr20:25228251 PYGB -0.37 -5.43 -0.32 1.3e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs10504073 0.647 rs4493918 chr8:50015937 C/G cg00325661 chr8:49890786 NA 0.57 8.6 0.47 7.15e-16 Blood metabolite ratios; CESC cis rs916888 0.821 rs415430 chr17:44859144 C/T cg17911788 chr17:44343683 NA 0.53 7.17 0.4 7.3e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs116095464 0.558 rs2162870 chr5:228129 G/A cg10591111 chr5:226296 SDHA -0.54 -6.65 -0.38 1.72e-10 Breast cancer; CESC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg25072359 chr17:41440525 NA 0.44 5.88 0.34 1.23e-8 Menopause (age at onset); CESC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg13770153 chr20:60521292 NA -0.48 -6.23 -0.36 1.81e-9 Body mass index; CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg15147215 chr3:52552868 STAB1 -0.3 -5.47 -0.32 1.02e-7 Bipolar disorder; CESC cis rs9549367 0.789 rs7338235 chr13:113888687 T/C cg18105134 chr13:113819100 PROZ -0.66 -7.86 -0.43 9.75e-14 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04444761 chr8:126442446 TRIB1 -0.55 -6.46 -0.37 4.89e-10 Gut microbiome composition (summer); CESC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg04518342 chr5:131593106 PDLIM4 0.4 6.08 0.35 4.24e-9 Breast cancer; CESC cis rs9814567 0.712 rs9838621 chr3:134332319 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.1 -0.3 6.38e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs3936840 0.565 rs8011721 chr14:102986388 C/G cg18135206 chr14:102964638 TECPR2 -0.5 -6.38 -0.36 7.99e-10 Plateletcrit; CESC cis rs2243480 0.901 rs73142137 chr7:65343442 A/T cg18252515 chr7:66147081 NA -1.18 -11.4 -0.57 9.2e-25 Diabetic kidney disease; CESC cis rs2180341 1.000 rs2180341 chr6:127600630 C/T cg24812749 chr6:127587940 RNF146 1.06 15.36 0.69 1.61e-38 Breast cancer; CESC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg22467129 chr15:76604101 ETFA -0.39 -5.96 -0.34 8.05e-9 Blood metabolite levels; CESC cis rs2228479 0.850 rs11649510 chr16:89851004 A/G cg04013166 chr16:89971882 TCF25 0.78 6.68 0.38 1.43e-10 Skin colour saturation; CESC cis rs847577 0.575 rs41278842 chr7:97815999 A/G cg24562669 chr7:97807699 LMTK2 -0.57 -8.37 -0.46 3.36e-15 Breast cancer; CESC cis rs6138458 1.000 rs227632 chr20:24913729 G/A cg06937882 chr20:24974362 C20orf3 -0.36 -5.2 -0.3 3.9e-7 Blood protein levels; CESC cis rs12136530 0.593 rs9287046 chr1:19736395 C/G cg01832549 chr1:19774989 CAPZB -0.43 -6.38 -0.36 7.97e-10 Lead levels in blood; CESC cis rs5769765 0.817 rs8142561 chr22:50291750 T/C cg02269571 chr22:50332266 NA -0.45 -6.05 -0.35 4.98e-9 Schizophrenia; CESC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs58785573 0.504 rs12646137 chr4:38609650 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.46 6.23 0.36 1.87e-9 Lymphocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17216600 chr6:52442344 TRAM2 0.59 6.48 0.37 4.55e-10 Gut microbiome composition (summer); CESC cis rs9309473 0.687 rs7576824 chr2:73611281 C/T cg20560298 chr2:73613845 ALMS1 0.51 6.95 0.39 2.9100000000000002e-11 Metabolite levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02056921 chr1:901892 PLEKHN1 0.47 6.2 0.36 2.15e-9 Systemic lupus erythematosus; CESC cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg26116260 chr4:7069785 GRPEL1 -0.87 -8.81 -0.48 1.7e-16 Monocyte percentage of white cells; CESC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.84 0.59 2.99e-26 Alzheimer's disease; CESC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 10.52 0.54 7.52e-22 Platelet count; CESC cis rs7980687 0.506 rs1611973 chr12:123622731 C/G cg05973401 chr12:123451056 ABCB9 0.54 6.91 0.39 3.51e-11 Height;Educational attainment;Head circumference (infant); CESC trans rs9467711 0.606 rs66827971 chr6:26365766 T/C cg06606381 chr12:133084897 FBRSL1 -0.76 -6.82 -0.39 6.01e-11 Autism spectrum disorder or schizophrenia; CESC cis rs7267979 0.934 rs6037085 chr20:25305202 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.41 -0.75 2.54e-49 Liver enzyme levels (alkaline phosphatase); CESC cis rs959260 0.688 rs4789176 chr17:73352868 A/T cg20590849 chr17:73267439 MIF4GD -0.55 -6.16 -0.35 2.62e-9 Systemic lupus erythematosus; CESC cis rs11969893 0.737 rs4098482 chr6:101377808 C/T cg12253828 chr6:101329408 ASCC3 0.96 8.17 0.45 1.26e-14 Economic and political preferences (immigration/crime); CESC cis rs6540559 0.543 rs650728 chr1:210433351 C/T cg21951975 chr1:209979733 IRF6 0.49 6.09 0.35 4.01e-9 Cleft lip with or without cleft palate; CESC cis rs6088580 0.634 rs6059866 chr20:33075810 A/C cg06115741 chr20:33292138 TP53INP2 0.4 5.2 0.3 4.08e-7 Glomerular filtration rate (creatinine); CESC cis rs2074585 0.708 rs2589939 chr15:90930875 C/T cg10434728 chr15:90938212 IQGAP1 0.43 7.8 0.43 1.46e-13 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18125479 chr14:51411049 PYGL -0.5 -7.26 -0.41 4.3e-12 Gambling; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg05477027 chr19:46295590 DMWD -0.46 -6.3 -0.36 1.21e-9 Height; CESC cis rs9911578 0.967 rs7503190 chr17:57184162 A/C cg12560992 chr17:57184187 TRIM37 1.01 17.89 0.74 1.77e-47 Intelligence (multi-trait analysis); CESC cis rs593982 0.920 rs488170 chr11:65481544 T/C cg08755490 chr11:65554678 OVOL1 1.17 10.74 0.55 1.45e-22 Atopic dermatitis; CESC cis rs4704187 0.687 rs4345300 chr5:74376571 C/T cg03227963 chr5:74354835 NA 0.32 5.95 0.34 8.68e-9 Response to amphetamines; CESC cis rs4642101 0.662 rs3901664 chr3:12824660 T/C cg24848339 chr3:12840334 CAND2 0.42 6.64 0.38 1.78e-10 QRS complex (12-leadsum); CESC cis rs2742417 1.000 rs2742397 chr3:45758946 C/G cg10512202 chr3:45649293 LIMD1 -0.36 -5.23 -0.31 3.4e-7 Response to anti-depressant treatment in major depressive disorder; CESC trans rs1545843 0.593 rs4584624 chr12:84798715 G/A cg03015433 chr16:56623111 MT3 -0.34 -6.14 -0.35 3.04e-9 Major depressive disorder; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08043048 chr2:197036688 STK17B -0.46 -6.71 -0.38 1.19e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2204008 0.774 rs7305085 chr12:38263511 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.29 0.36 1.29e-9 Bladder cancer; CESC cis rs1878047 0.665 rs12972826 chr19:51775531 G/A cg14884932 chr19:51774451 NA -0.37 -5.16 -0.3 4.87e-7 Body mass index; CESC cis rs8018808 0.936 rs4903576 chr14:77844869 A/G cg20045696 chr14:77926864 AHSA1 -0.37 -5.06 -0.3 7.85e-7 Myeloid white cell count; CESC cis rs11958404 0.615 rs7724696 chr5:157450852 A/C cg05962755 chr5:157440814 NA 0.38 5.65 0.33 4.06e-8 IgG glycosylation; CESC trans rs11678036 1.000 rs11678036 chr2:186024735 A/G cg19931206 chr6:11138650 LOC221710 -0.43 -6.38 -0.36 8.08e-10 IgG glycosylation; CESC cis rs1062746 0.771 rs10514621 chr16:87369578 G/T cg02258303 chr16:87377426 FBXO31 -0.5 -6.35 -0.36 9.21e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CESC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg05255149 chr17:80675120 FN3KRP 0.46 5.19 0.3 4.25e-7 Glycated hemoglobin levels; CESC cis rs2243480 1.000 rs1715235 chr7:65488394 T/C cg18252515 chr7:66147081 NA -1.19 -11.57 -0.58 2.56e-25 Diabetic kidney disease; CESC cis rs4730250 0.708 rs3801965 chr7:106825628 G/T cg02696742 chr7:106810147 HBP1 -0.53 -5.06 -0.3 7.68e-7 Osteoarthritis; CESC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg26314531 chr2:26401878 FAM59B 0.73 7.64 0.42 4.03e-13 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg19163074 chr7:65112434 INTS4L2 -0.41 -5.11 -0.3 6.29e-7 Aortic root size; CESC trans rs55704346 0.566 rs11937932 chr4:25387660 A/G cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -5.18 -0.3 4.41e-7 Developmental language disorder (linguistic errors); CESC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg22862634 chr11:62369728 EML3;MTA2 0.53 7.5 0.42 9.64e-13 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg16339924 chr4:17578868 LAP3 0.61 7.5 0.42 9.61e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9611565 0.559 rs4822049 chr22:41993496 G/A cg17376030 chr22:41985996 PMM1 0.81 8.45 0.46 1.98e-15 Vitiligo; CESC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.74 7.45 0.42 1.29e-12 Platelet count; CESC cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg19193384 chr17:30244184 NA -0.64 -6.05 -0.35 4.85e-9 Hip circumference adjusted for BMI; CESC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Lung function (FEV1); CESC cis rs9814567 0.731 rs34797591 chr3:134192516 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.4 5.26 0.31 2.91e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09992653 chr13:53226650 SUGT1 -0.54 -6.33 -0.36 1.07e-9 Gut microbiome composition (summer); CESC cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg19717773 chr7:2847554 GNA12 -0.52 -8.18 -0.45 1.22e-14 Height; CESC trans rs116095464 0.558 rs7356535 chr5:284117 G/T cg00938859 chr5:1591904 SDHAP3 0.72 6.62 0.38 2.04e-10 Breast cancer; CESC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg19717773 chr7:2847554 GNA12 -0.54 -7.75 -0.43 1.92e-13 Height; CESC cis rs4604732 0.631 rs11490200 chr1:247625915 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7772486 0.875 rs9322043 chr6:146352690 A/G cg23711669 chr6:146136114 FBXO30 0.87 12.8 0.62 1.63e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs6828523 0.698 rs78557674 chr4:175853032 T/A cg14561282 chr4:175839468 ADAM29 0.43 5.04 0.3 8.73e-7 Breast cancer; CESC cis rs1775715 0.870 rs10827003 chr10:32266216 A/G cg18675610 chr10:32216311 ARHGAP12 0.33 5.14 0.3 5.29e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4132509 1.000 rs28869008 chr1:243986344 C/A cg21452805 chr1:244014465 NA 0.5 6.21 0.36 2.08e-9 RR interval (heart rate); CESC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg18512352 chr11:47633146 NA 0.44 6.31 0.36 1.18e-9 Subjective well-being; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07531037 chr17:43196299 PLCD3 0.49 6.58 0.37 2.57e-10 Fibrinogen levels; CESC cis rs10779751 0.690 rs2791659 chr1:11126569 C/A cg08854313 chr1:11322531 MTOR 0.77 10.41 0.54 1.73e-21 Body mass index; CESC cis rs10791323 0.569 rs329664 chr11:133754975 G/T cg15485101 chr11:133734466 NA 0.3 5.19 0.3 4.26e-7 Childhood ear infection; CESC cis rs3091242 0.933 rs10903130 chr1:25769221 A/T cg27572855 chr1:25598939 RHD 0.43 7.22 0.41 5.47e-12 Erythrocyte sedimentation rate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10599693 chr2:24300242 SF3B14 -0.41 -6.13 -0.35 3.24e-9 Gambling; CESC cis rs77861329 1.000 rs13319566 chr3:52095555 C/G cg08692210 chr3:52188851 WDR51A 0.8 7.04 0.4 1.61e-11 Macrophage inflammatory protein 1b levels; CESC cis rs8077889 0.871 rs9893111 chr17:41915767 G/A cg26893861 chr17:41843967 DUSP3 0.71 8.8 0.48 1.85e-16 Triglycerides; CESC cis rs11608355 0.515 rs6606727 chr12:109941450 T/A cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg17376030 chr22:41985996 PMM1 0.82 8.55 0.47 9.88e-16 Vitiligo; CESC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 8.33 0.46 4.25e-15 Platelet count; CESC trans rs12478296 0.901 rs67423532 chr2:243004719 A/G cg18288967 chr1:45987694 PRDX1 0.59 6.55 0.37 2.93e-10 Obesity-related traits; CESC cis rs1387259 0.859 rs2054905 chr12:48687951 A/G cg04545296 chr12:48745243 ZNF641 0.42 7.0 0.39 2.11e-11 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs916888 0.821 rs199512 chr17:44857352 T/C cg17911788 chr17:44343683 NA 0.53 7.2 0.4 6.14e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9911578 1.000 rs12453049 chr17:56611372 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.53 -0.32 7.63e-8 Intelligence (multi-trait analysis); CESC cis rs75804782 0.641 rs11902599 chr2:239348400 C/T cg18131467 chr2:239335373 ASB1 -0.66 -5.83 -0.34 1.58e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg10351095 chr21:47802916 PCNT 0.43 5.55 0.32 7.02e-8 Testicular germ cell tumor; CESC cis rs881375 0.669 rs73541868 chr9:123639264 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 6.41 0.37 6.75e-10 Rheumatoid arthritis; CESC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Depression; CESC cis rs660899 0.595 rs37458 chr1:44290530 A/G cg11704212 chr1:44303111 ST3GAL3 -0.39 -5.29 -0.31 2.51e-7 Hypertension risk in short sleep duration; CESC cis rs7072216 0.727 rs942809 chr10:100168001 G/A cg26618903 chr10:100175079 PYROXD2 -0.33 -5.11 -0.3 6.23e-7 Metabolite levels; CESC cis rs4268898 0.610 rs55860688 chr2:24451534 T/C cg08917208 chr2:24149416 ATAD2B 0.53 5.24 0.31 3.2e-7 Asthma; CESC cis rs3820928 0.874 rs59630650 chr2:227786514 T/C cg05526886 chr2:227700861 RHBDD1 -0.41 -5.23 -0.31 3.47e-7 Pulmonary function; CESC cis rs16857609 0.564 rs13388148 chr2:218281500 T/G cg15335768 chr2:218268053 DIRC3 -0.38 -5.53 -0.32 7.68e-8 Breast cancer;Breast cancer (estrogen-receptor negative); CESC cis rs12579753 0.917 rs7313521 chr12:82205656 G/A cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs7020830 0.931 rs3802422 chr9:37097172 G/A cg14294708 chr9:37120828 ZCCHC7 1.26 25.17 0.84 3.15e-72 Schizophrenia; CESC cis rs2228479 0.850 rs62056065 chr16:89905115 C/G cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg08470875 chr2:26401718 FAM59B -0.74 -7.65 -0.43 3.74e-13 Gut microbiome composition (summer); CESC cis rs2354432 0.607 rs894471 chr1:146687913 A/G cg25205988 chr1:146714368 CHD1L -0.89 -6.95 -0.39 2.9e-11 Mitochondrial DNA levels; CESC cis rs662064 0.962 rs2781230 chr1:10563717 G/A cg20482658 chr1:10539492 PEX14 0.38 7.3 0.41 3.44e-12 Asthma; CESC cis rs7617773 0.501 rs12185901 chr3:48382919 G/T cg11946769 chr3:48343235 NME6 0.66 8.34 0.46 4.12e-15 Coronary artery disease; CESC cis rs3733585 0.699 rs1079128 chr4:9951221 T/C cg00071950 chr4:10020882 SLC2A9 -0.71 -11.89 -0.59 2.08e-26 Cleft plate (environmental tobacco smoke interaction); CESC trans rs1814175 0.715 rs1722007 chr11:49897319 T/C cg03929089 chr4:120376271 NA -0.91 -15.11 -0.68 1.28e-37 Height; CESC cis rs9611519 0.780 rs2284079 chr22:41658632 C/T cg03806693 chr22:41940476 POLR3H -0.56 -6.46 -0.37 4.91e-10 Neuroticism; CESC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg20203395 chr5:56204925 C5orf35 0.46 5.37 0.31 1.73e-7 Initial pursuit acceleration; CESC cis rs11785693 0.862 rs11784262 chr8:4996942 G/A cg26367366 chr8:4980734 NA 0.63 6.28 0.36 1.36e-9 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs5758659 0.652 rs4822084 chr22:42435868 A/G cg15557168 chr22:42548783 NA 0.45 6.69 0.38 1.3e-10 Cognitive function; CESC cis rs362272 0.524 rs7435601 chr4:3369645 A/G cg14583973 chr4:3374767 RGS12 0.31 5.44 0.32 1.19e-7 Serum sulfate level; CESC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.95 14.1 0.65 4.6e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2777491 1.000 rs2730057 chr15:41736275 C/A cg18705301 chr15:41695430 NDUFAF1 -0.67 -10.16 -0.53 1.12e-20 Ulcerative colitis; CESC trans rs617791 0.669 rs4994056 chr11:65750997 G/A cg17712092 chr4:129076599 LARP1B 0.72 9.97 0.52 4.33e-20 Breast cancer; CESC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg19901468 chr14:105411992 AHNAK2 -0.6 -8.69 -0.47 3.74e-16 Rheumatoid arthritis; CESC cis rs2115536 0.704 rs2163005 chr15:80194480 A/G cg00225070 chr15:80189496 MTHFS 0.64 8.8 0.48 1.83e-16 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02769252 chr17:25932535 KSR1 -0.53 -6.35 -0.36 9.42e-10 Gut microbiome composition (summer); CESC cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg22823121 chr1:150693482 HORMAD1 -0.36 -5.37 -0.31 1.68e-7 Tonsillectomy; CESC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg04369109 chr6:150039330 LATS1 -0.44 -6.1 -0.35 3.82e-9 Lung cancer; CESC cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.25 0.31 3.12e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10870270 0.956 rs10781555 chr10:133745720 G/A cg08754478 chr10:133766260 PPP2R2D -0.61 -7.93 -0.44 6.3e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs10911251 0.528 rs2182020 chr1:183074964 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.05e-34 Colorectal cancer; CESC cis rs2228479 0.867 rs75110337 chr16:89962635 C/A cg04013166 chr16:89971882 TCF25 0.76 6.94 0.39 3.06e-11 Skin colour saturation; CESC trans rs11098499 0.863 rs3822195 chr4:120471660 C/T cg25214090 chr10:38739885 LOC399744 0.67 9.15 0.49 1.55e-17 Corneal astigmatism; CESC cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg27286337 chr10:134555280 INPP5A 0.62 7.31 0.41 3.07e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9916302 0.904 rs34363096 chr17:37594294 G/A cg15445000 chr17:37608096 MED1 0.41 6.74 0.38 9.67e-11 Glomerular filtration rate (creatinine); CESC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg09658497 chr7:2847517 GNA12 -0.42 -5.87 -0.34 1.27e-8 Height; CESC cis rs854765 0.647 rs6502637 chr17:17986098 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.68 0.47 4.14e-16 Total body bone mineral density; CESC cis rs362296 0.661 rs3095077 chr4:3265710 A/G cg08886695 chr4:3369023 RGS12 -0.36 -5.23 -0.31 3.53e-7 Parental longevity (mother's age at death); CESC cis rs425277 0.958 rs262688 chr1:2113565 T/G cg16545954 chr1:2118288 C1orf86 0.33 5.68 0.33 3.45e-8 Height; CESC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg10295955 chr4:187884368 NA -1.02 -20.59 -0.78 6.65e-57 Lobe attachment (rater-scored or self-reported); CESC cis rs7818345 1.000 rs13278459 chr8:19297583 A/G cg11303988 chr8:19266685 CSGALNACT1 0.34 6.23 0.36 1.85e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs9926296 0.712 rs258330 chr16:89729574 T/G cg27121462 chr16:89883253 FANCA -0.47 -5.75 -0.33 2.48e-8 Vitiligo; CESC cis rs2239547 0.657 rs6445538 chr3:52874288 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.4 0.37 7.09e-10 Schizophrenia; CESC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg05564831 chr3:52568323 NT5DC2 0.45 6.94 0.39 3.06e-11 Bipolar disorder; CESC trans rs1493916 0.905 rs7239283 chr18:31395397 G/A cg27147174 chr7:100797783 AP1S1 -0.54 -7.28 -0.41 3.85e-12 Life satisfaction; CESC cis rs72945132 0.882 rs1061328 chr11:70185325 C/T cg00319359 chr11:70116639 PPFIA1 0.71 6.92 0.39 3.49e-11 Coronary artery disease; CESC cis rs9837602 0.529 rs793459 chr3:99520591 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.62 -9.72 -0.51 2.66e-19 Breast cancer; CESC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg27535305 chr1:53392650 SCP2 -0.32 -5.49 -0.32 9.21e-8 Monocyte count; CESC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg10351095 chr21:47802916 PCNT -0.48 -6.44 -0.37 5.64e-10 Testicular germ cell tumor; CESC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Parkinson's disease; CESC cis rs6460942 1.000 rs6460935 chr7:12401317 A/T cg02935154 chr7:12443704 VWDE -0.57 -6.18 -0.35 2.42e-9 Coronary artery disease; CESC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg07936489 chr17:37558343 FBXL20 -0.75 -10.32 -0.54 3.35e-21 Glomerular filtration rate (creatinine); CESC cis rs9549367 0.673 rs575453 chr13:113837871 C/A cg18105134 chr13:113819100 PROZ 0.56 7.11 0.4 1.05e-11 Platelet distribution width; CESC cis rs763014 0.931 rs7191939 chr16:630089 C/T cg00908189 chr16:619842 PIGQ 0.67 9.29 0.5 6.02e-18 Height; CESC cis rs1035144 0.505 rs10145099 chr14:81456694 C/T cg06600135 chr14:81408086 NA -0.56 -7.4 -0.41 1.85e-12 Male sexual orientation; CESC cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg13902645 chr11:5959945 NA -0.66 -7.99 -0.44 4.21e-14 DNA methylation (variation); CESC cis rs2204008 0.777 rs2049130 chr12:38444837 G/A cg13010199 chr12:38710504 ALG10B 0.42 5.43 0.32 1.28e-7 Bladder cancer; CESC trans rs2814021 0.599 rs2650720 chr10:63264332 C/T cg08188886 chr14:105633697 JAG2 -0.42 -6.09 -0.35 3.95e-9 Obesity-related traits; CESC cis rs11098499 0.863 rs1480940 chr4:120457682 T/C cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs2412459 0.611 rs4924402 chr15:40245754 C/T cg21830797 chr15:40226279 EIF2AK4 -0.49 -5.5 -0.32 9.01e-8 Response to haloperidol in psychosis; CESC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs4523957 0.583 rs8067895 chr17:2030234 G/A cg16513277 chr17:2031491 SMG6 -0.79 -11.51 -0.58 3.93e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs73206853 0.841 rs73206886 chr12:110851190 T/G cg12870014 chr12:110450643 ANKRD13A 0.63 5.18 0.3 4.34e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs6088590 0.687 rs13044899 chr20:33287078 G/A cg06115741 chr20:33292138 TP53INP2 0.49 5.88 0.34 1.21e-8 Coronary artery disease; CESC cis rs12497850 0.931 rs7616815 chr3:48779715 C/T cg06212747 chr3:49208901 KLHDC8B 0.64 8.74 0.47 2.8e-16 Parkinson's disease; CESC cis rs7590368 0.640 rs56260452 chr2:10954843 C/G cg15705551 chr2:10952987 PDIA6 0.52 5.12 0.3 5.91e-7 Educational attainment (years of education); CESC cis rs6502050 0.835 rs4789672 chr17:80126603 T/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.97e-7 Life satisfaction; CESC cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg13902645 chr11:5959945 NA -0.58 -6.67 -0.38 1.49e-10 DNA methylation (variation); CESC cis rs16858210 0.529 rs10937154 chr3:183569489 C/T cg25686905 chr3:183603175 PARL -0.33 -5.84 -0.34 1.48e-8 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20273122 chr11:68671309 IGHMBP2;MRPL21 0.59 6.37 0.36 8.35e-10 Gut microbiome composition (summer); CESC cis rs2304069 0.545 rs9686746 chr5:149399968 G/A cg12661370 chr5:149340060 SLC26A2 0.41 5.42 0.32 1.33e-7 HIV-1 control; CESC trans rs274437 0.739 rs12197788 chr6:104791156 G/A cg23629166 chr1:2345368 PEX10 0.56 6.04 0.35 5.16e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3806843 0.705 rs35614340 chr5:140043618 C/G cg16179182 chr5:140090404 VTRNA1-1 0.4 5.16 0.3 4.88e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2797685 0.898 rs697693 chr1:7886424 C/T cg04725166 chr1:7887271 PER3 -0.47 -6.72 -0.38 1.1e-10 Crohn's disease; CESC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.79 0.52 1.65e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs17376456 1.000 rs13163610 chr5:93548877 A/C cg21475434 chr5:93447410 FAM172A 0.83 7.48 0.42 1.1e-12 Diabetic retinopathy; CESC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg06212747 chr3:49208901 KLHDC8B 0.68 9.45 0.5 1.86e-18 Parkinson's disease; CESC cis rs10870270 1.000 rs11146338 chr10:133770291 C/G cg08754478 chr10:133766260 PPP2R2D -0.59 -7.57 -0.42 6.29e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs6963495 0.745 rs55906043 chr7:105165367 T/G cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs7107174 1.000 rs1942352 chr11:77970563 T/G cg02023728 chr11:77925099 USP35 0.52 7.5 0.42 9.85e-13 Testicular germ cell tumor; CESC cis rs3741151 0.773 rs11820577 chr11:73261424 C/G cg17517138 chr11:73019481 ARHGEF17 0.86 6.82 0.39 6.26e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs1832871 0.643 rs7750656 chr6:158725907 C/T cg07165851 chr6:158734300 TULP4 0.61 6.77 0.38 8.06e-11 Height; CESC trans rs354225 0.539 rs6752720 chr2:54962352 G/A cg08887902 chr7:77428575 PHTF2;TMEM60 -0.61 -6.18 -0.35 2.42e-9 Schizophrenia; CESC cis rs8103278 0.826 rs11669442 chr19:46374557 A/G cg14061069 chr19:46274453 DMPK -0.39 -5.47 -0.32 1.03e-7 Coronary artery disease; CESC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.46 6.17 0.35 2.6e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs314370 0.951 rs12705095 chr7:100484381 T/G cg10426581 chr7:100472382 SRRT 0.85 8.23 0.45 8.68e-15 Resting heart rate; CESC cis rs8028182 0.549 rs7402844 chr15:75637396 C/G cg20655648 chr15:75932815 IMP3 -0.42 -5.26 -0.31 3.03e-7 Sudden cardiac arrest; CESC cis rs2832191 0.716 rs7509628 chr21:30454252 C/T cg24692254 chr21:30365293 RNF160 0.99 17.57 0.73 2.33e-46 Dental caries; CESC cis rs9303401 0.659 rs34556735 chr17:56694447 A/C cg02118635 chr17:56770003 RAD51C;TEX14 1.0 11.64 0.58 1.4e-25 Cognitive test performance; CESC cis rs9300255 0.568 rs1621194 chr12:123651018 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.16e-16 Neutrophil percentage of white cells; CESC cis rs4555082 0.789 rs2816649 chr14:105708326 A/G cg27165867 chr14:105738592 BRF1 -0.5 -5.81 -0.34 1.8e-8 Mean platelet volume;Platelet distribution width; CESC cis rs7296418 0.922 rs12425009 chr12:123502044 C/T cg00376283 chr12:123451042 ABCB9 0.75 10.88 0.56 4.77e-23 Platelet count; CESC cis rs10883723 0.810 rs10883728 chr10:104269301 A/G ch.10.2196322F chr10:104248062 ACTR1A -0.44 -5.44 -0.32 1.19e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs6687430 0.512 rs34575776 chr1:10621061 A/G cg20482658 chr1:10539492 PEX14 0.39 7.93 0.44 6.24e-14 Hand grip strength; CESC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg02569458 chr12:86230093 RASSF9 -0.52 -7.61 -0.42 4.68e-13 Major depressive disorder; CESC cis rs6466055 0.720 rs13239067 chr7:105011629 T/A cg04380332 chr7:105027541 SRPK2 -0.41 -5.33 -0.31 2.07e-7 Schizophrenia; CESC cis rs3845702 0.935 rs3845695 chr2:180796989 A/G cg01881094 chr2:180872142 CWC22 -0.71 -7.32 -0.41 2.9e-12 Schizophrenia; CESC cis rs8067545 0.636 rs11204300 chr17:20195438 C/T cg13482628 chr17:19912719 NA -0.42 -5.61 -0.33 5.2e-8 Schizophrenia; CESC cis rs9814567 1.000 rs28409322 chr3:134252385 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs11122272 0.735 rs2749709 chr1:231530476 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -7.12 -0.4 9.89e-12 Hemoglobin concentration; CESC cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.35 0.6 5.57e-28 Personality dimensions; CESC cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg05283184 chr6:79620031 NA -0.43 -6.56 -0.37 2.85e-10 Intelligence (multi-trait analysis); CESC trans rs9951602 0.512 rs1903722 chr18:76646539 G/A cg02800362 chr5:177631904 HNRNPAB 0.61 7.97 0.44 4.84e-14 Obesity-related traits; CESC cis rs2637266 1.000 rs2395389 chr10:78357701 C/T cg18941641 chr10:78392320 NA 0.42 7.73 0.43 2.28e-13 Pulmonary function; CESC trans rs8014204 0.816 rs10083386 chr14:75347585 C/A cg22117143 chr9:13251431 MPDZ 0.38 6.03 0.35 5.59e-9 Caffeine consumption; CESC trans rs2270927 0.834 rs4496693 chr5:75576729 T/C cg13563193 chr19:33072644 PDCD5 0.74 6.26 0.36 1.53e-9 Mean corpuscular volume; CESC cis rs61996546 0.622 rs12907116 chr15:26857399 A/G cg15066197 chr15:26874202 GABRB3 -0.35 -5.09 -0.3 6.95e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs9902453 1.000 rs9890205 chr17:28382704 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.09e-13 Coffee consumption (cups per day); CESC cis rs7089973 0.604 rs2420066 chr10:116583897 A/G cg23260525 chr10:116636907 FAM160B1 0.38 6.86 0.39 4.82e-11 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2645694 0.626 rs2703124 chr4:77820626 G/T cg10057126 chr4:77819792 ANKRD56 0.59 8.69 0.47 3.72e-16 Emphysema distribution in smoking; CESC cis rs8038465 0.568 rs62004592 chr15:73878019 A/G cg15420318 chr15:73925796 NPTN 0.5 6.99 0.39 2.18e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.78 0.65 6.21e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.91 0.34 1.03e-8 Tonsillectomy; CESC cis rs950169 0.881 rs62029596 chr15:84955434 A/G cg17507749 chr15:85114479 UBE2QP1 0.59 6.54 0.37 3.11e-10 Schizophrenia; CESC cis rs113835537 0.597 rs7939759 chr11:66337964 C/T cg24851651 chr11:66362959 CCS 0.5 5.96 0.34 7.95e-9 Airway imaging phenotypes; CESC cis rs7618501 0.521 rs868891 chr3:49949071 A/G cg24308560 chr3:49941425 MST1R -0.58 -8.38 -0.46 3.15e-15 Intelligence (multi-trait analysis); CESC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg11764359 chr7:65958608 NA 0.79 9.51 0.5 1.18e-18 Aortic root size; CESC trans rs3780486 0.801 rs56687083 chr9:33132134 A/G cg20290983 chr6:43655470 MRPS18A 0.99 18.35 0.75 4.06e-49 IgG glycosylation; CESC cis rs1005277 0.505 rs7917943 chr10:38195811 T/A cg25427524 chr10:38739819 LOC399744 0.69 10.35 0.54 2.59e-21 Extrinsic epigenetic age acceleration; CESC cis rs7193541 0.965 rs7199068 chr16:74698263 C/G cg01733217 chr16:74700730 RFWD3 0.98 14.95 0.68 4.57e-37 Multiple myeloma; CESC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg08704250 chr15:31115839 NA -0.63 -8.17 -0.45 1.28e-14 Huntington's disease progression; CESC trans rs877282 1.000 rs12763443 chr10:771941 G/A cg22713356 chr15:30763199 NA 1.26 12.69 0.61 3.79e-29 Uric acid levels; CESC trans rs5758511 0.773 rs7288749 chr22:42356430 C/T cg15080870 chr19:47770746 CCDC9 0.49 6.11 0.35 3.49e-9 Birth weight; CESC cis rs9467711 0.606 rs9379900 chr6:26603811 A/C cg14345882 chr6:26364793 BTN3A2 0.56 5.96 0.34 7.82e-9 Autism spectrum disorder or schizophrenia; CESC cis rs4803468 0.967 rs284661 chr19:41932120 C/T cg09537434 chr19:41945824 ATP5SL -1.05 -19.17 -0.76 5.5e-52 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23415789 chr17:59445792 BCAS3 0.45 6.12 0.35 3.42e-9 Fibrinogen levels; CESC cis rs7243790 1.000 rs7243790 chr18:51961763 T/G cg04730925 chr18:51795821 POLI -0.42 -5.54 -0.32 7.12e-8 Diastolic blood pressure; CESC cis rs1322639 1.000 rs1322639 chr6:169587103 G/A cg03254818 chr6:169586852 NA -0.53 -7.25 -0.41 4.57e-12 Pulse pressure; CESC cis rs75477785 1.000 rs75477785 chr1:209984470 T/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs1712517 0.525 rs11191667 chr10:105128898 G/A cg04362960 chr10:104952993 NT5C2 -0.47 -5.66 -0.33 4.01e-8 Migraine; CESC cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg02079420 chr8:82753780 SNX16 0.54 8.14 0.45 1.52e-14 Diastolic blood pressure; CESC trans rs853679 0.824 rs34712084 chr6:28043828 A/G cg06606381 chr12:133084897 FBRSL1 -0.66 -6.0 -0.35 6.41e-9 Depression; CESC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.46 0.32 1.12e-7 Bipolar disorder; CESC cis rs9914988 0.943 rs9890377 chr17:27111111 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg24578937 chr1:2090814 PRKCZ 0.38 6.59 0.38 2.32e-10 Height; CESC cis rs6543140 0.964 rs1523205 chr2:103070176 G/T cg04239558 chr2:103089729 SLC9A4 0.47 5.99 0.35 6.67e-9 Blood protein levels; CESC cis rs8180040 0.966 rs2101247 chr3:47494303 G/A cg27129171 chr3:47204927 SETD2 -0.63 -9.44 -0.5 1.95e-18 Colorectal cancer; CESC cis rs9911578 1.000 rs391370 chr17:56675050 A/C cg05425664 chr17:57184151 TRIM37 -0.51 -7.13 -0.4 9.35e-12 Intelligence (multi-trait analysis); CESC cis rs6570726 0.764 rs9386125 chr6:145911677 C/T cg23711669 chr6:146136114 FBXO30 0.92 13.58 0.64 3.16e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs7208859 0.623 rs9916727 chr17:29107472 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4789693 0.938 rs12952655 chr17:80421139 C/T cg04308225 chr17:80449738 NA -0.45 -5.36 -0.31 1.79e-7 Glucocorticoid-induced osteonecrosis; CESC cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.79 8.79 0.48 1.87e-16 Alzheimer's disease; CESC cis rs2072732 0.808 rs56091202 chr1:2936803 A/G cg03976712 chr1:2946727 NA 0.33 5.17 0.3 4.53e-7 Plateletcrit; CESC cis rs9611565 0.694 rs5758347 chr22:41821019 G/T cg06634786 chr22:41940651 POLR3H 0.71 7.17 0.4 7.6e-12 Vitiligo; CESC cis rs9916302 0.706 rs4287601 chr17:37513852 T/C cg07936489 chr17:37558343 FBXL20 0.89 9.69 0.51 3.45e-19 Glomerular filtration rate (creatinine); CESC cis rs4642101 0.597 rs12638595 chr3:12819281 T/C cg05775895 chr3:12838266 CAND2 0.37 5.42 0.32 1.36e-7 QRS complex (12-leadsum); CESC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg03934478 chr11:495069 RNH1 0.55 5.31 0.31 2.37e-7 Body mass index; CESC cis rs1879734 0.731 rs11206200 chr1:54168545 T/C cg23596471 chr1:54105337 GLIS1 0.34 5.44 0.32 1.19e-7 Mitral valve prolapse; CESC cis rs9399137 0.507 rs4896118 chr6:135276065 A/G cg22676075 chr6:135203613 NA -0.48 -6.25 -0.36 1.6e-9 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.53 0.51 1.06e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13781829 chr10:93558071 TNKS2 0.58 6.33 0.36 1.07e-9 Gut microbiome composition (summer); CESC cis rs72848980 0.512 rs56984020 chr10:105386275 C/A cg00126946 chr10:105363258 SH3PXD2A 0.6 8.55 0.46 1e-15 White matter hyperintensity burden; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17930852 chr1:45957182 TESK2 -0.57 -7.28 -0.41 3.7e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15891644 chr15:40751006 BAHD1 -0.5 -6.15 -0.35 2.78e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9894429 0.671 rs6565616 chr17:79612161 C/T cg13777783 chr17:79615861 NA -0.37 -6.17 -0.35 2.61e-9 Eye color traits; CESC cis rs2228479 0.618 rs34689166 chr16:89860697 C/T cg14709524 chr16:89940631 TCF25 0.93 6.97 0.39 2.5e-11 Skin colour saturation; CESC cis rs4737010 0.578 rs4466386 chr8:41679853 A/G cg08923054 chr8:41654455 ANK1 0.51 6.73 0.38 1.03e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs7824557 0.724 rs2251473 chr8:11177126 C/A cg21775007 chr8:11205619 TDH 0.41 5.72 0.33 2.82e-8 Retinal vascular caliber; CESC cis rs3015497 0.550 rs2934666 chr14:51154703 T/G cg26011998 chr14:51135199 SAV1 -0.55 -5.97 -0.34 7.45e-9 Mean platelet volume; CESC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg26354017 chr1:205819088 PM20D1 0.84 13.17 0.63 8.53e-31 Menarche (age at onset); CESC cis rs11122272 0.735 rs973252 chr1:231520802 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs3741404 0.512 rs4980504 chr11:63873083 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.62 -8.18 -0.45 1.2e-14 Platelet count; CESC cis rs7772486 0.686 rs857882 chr6:145969716 T/G cg05347473 chr6:146136440 FBXO30 -0.55 -7.1 -0.4 1.12e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13789711 chr9:139743225 PHPT1 -0.52 -7.94 -0.44 5.67e-14 Gambling; CESC cis rs9322193 0.923 rs9322197 chr6:149943713 C/A cg13206674 chr6:150067644 NUP43 0.39 5.56 0.32 6.65e-8 Lung cancer; CESC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.88 13.16 0.63 8.67e-31 Prudent dietary pattern; CESC cis rs6800768 0.556 rs73134512 chr3:24089762 G/C cg10674438 chr3:24145617 LOC152024 -0.4 -5.45 -0.32 1.18e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs262150 0.731 rs2657388 chr7:158763428 A/G cg19418458 chr7:158789849 NA 0.39 5.92 0.34 9.7e-9 Facial morphology (factor 20); CESC cis rs2455799 0.613 rs7633542 chr3:15816326 C/T cg16303742 chr3:15540471 COLQ -0.39 -6.15 -0.35 2.83e-9 Mean platelet volume; CESC cis rs4450798 0.649 rs9310430 chr3:13781682 A/G cg23332027 chr3:13681764 NA 0.38 5.2 0.3 4.01e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs3825932 0.778 rs1369324 chr15:79239719 C/T cg25744700 chr15:79237217 CTSH -0.5 -6.72 -0.38 1.09e-10 Type 1 diabetes; CESC cis rs2933343 0.700 rs2624910 chr3:128650275 G/C cg24203234 chr3:128598194 ACAD9 0.44 5.97 0.34 7.61e-9 IgG glycosylation; CESC cis rs75477785 0.590 rs4844916 chr1:210108196 A/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.94 6.89 0.39 4.04e-11 Cleft lip with or without cleft palate; CESC cis rs643506 0.774 rs11214033 chr11:111769702 G/A cg17089665 chr11:111648010 NA 0.39 5.72 0.33 2.85e-8 Breast cancer; CESC cis rs9287719 0.967 rs7600587 chr2:10739851 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs6540556 0.859 rs11119341 chr1:209940675 A/G cg05527609 chr1:210001259 C1orf107 0.56 6.97 0.39 2.49e-11 Red blood cell count; CESC cis rs9911578 1.000 rs1267545 chr17:56646909 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.02 -0.4 1.86e-11 Intelligence (multi-trait analysis); CESC cis rs9788333 0.762 rs4441120 chr13:21886863 T/A cg21970626 chr13:21893289 NA -0.39 -5.69 -0.33 3.31e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg07917127 chr4:99064746 C4orf37 0.43 5.21 0.3 3.86e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06708562 chr6:146285465 SHPRH 0.54 6.47 0.37 4.68e-10 Gut microbiome composition (summer); CESC trans rs3942852 0.868 rs11039514 chr11:48109598 A/G cg03929089 chr4:120376271 NA -0.55 -6.12 -0.35 3.42e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs2204008 0.743 rs11495614 chr12:38156358 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.04 0.35 5.25e-9 Bladder cancer; CESC cis rs208520 0.690 rs1304672 chr6:66847973 A/G cg07460842 chr6:66804631 NA 0.86 9.16 0.49 1.47e-17 Exhaled nitric oxide output; CESC cis rs9811920 0.683 rs793502 chr3:99588417 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 6.46 0.37 5.02e-10 Axial length; CESC cis rs425277 0.958 rs626479 chr1:2110260 A/G cg24578937 chr1:2090814 PRKCZ -0.54 -9.22 -0.49 9.39e-18 Height; CESC cis rs9457247 0.765 rs9457259 chr6:167444281 C/T cg23791538 chr6:167370224 RNASET2 -0.55 -7.59 -0.42 5.54e-13 Crohn's disease; CESC cis rs1927790 0.727 rs6491285 chr13:96944930 T/A cg02571835 chr13:96230311 CLDN10 -0.36 -5.3 -0.31 2.41e-7 Body mass index; CESC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg17971929 chr21:40555470 PSMG1 1.04 15.61 0.69 2.11e-39 Cognitive function; CESC cis rs3733585 0.674 rs7375643 chr4:9955239 A/G cg11266682 chr4:10021025 SLC2A9 -0.61 -12.65 -0.61 5.05e-29 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7408868 1.000 rs10418305 chr19:15278808 C/G cg14696996 chr19:15285081 NOTCH3 1.11 11.94 0.59 1.43e-26 Pulse pressure; CESC trans rs10743315 0.557 rs77344887 chr12:19312751 C/T cg09562322 chr12:119419143 SRRM4 -0.48 -6.11 -0.35 3.62e-9 Gut microbiota (bacterial taxa); CESC cis rs3008870 1.000 rs3008853 chr1:67385488 C/T cg02640540 chr1:67518911 SLC35D1 0.5 5.33 0.31 2.08e-7 Lymphocyte percentage of white cells; CESC cis rs2204008 0.837 rs11180549 chr12:38236950 A/G cg13010199 chr12:38710504 ALG10B 0.52 6.43 0.37 5.91e-10 Bladder cancer; CESC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg07308232 chr7:1071921 C7orf50 -0.44 -5.88 -0.34 1.26e-8 Longevity;Endometriosis; CESC cis rs4423214 0.840 rs1792315 chr11:71165547 C/T cg05163923 chr11:71159392 DHCR7 -0.63 -7.34 -0.41 2.61e-12 Vitamin D levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13381753 chr1:213189256 ANGEL2 0.49 6.32 0.36 1.12e-9 Systemic lupus erythematosus; CESC cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg13175981 chr1:150552382 MCL1 0.75 11.23 0.57 3.32e-24 Tonsillectomy; CESC cis rs9896933 0.830 rs113051447 chr17:80791806 A/G cg20578329 chr17:80767326 TBCD -0.62 -7.18 -0.4 6.87e-12 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs9487051 0.714 rs6927569 chr6:109621494 T/C cg12927641 chr6:109611667 NA -0.36 -5.26 -0.31 3.04e-7 Reticulocyte fraction of red cells; CESC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg25072359 chr17:41440525 NA 0.51 7.5 0.42 9.61e-13 Menopause (age at onset); CESC cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.52 0.46 1.24e-15 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg08859206 chr1:53392774 SCP2 0.57 7.13 0.4 9.66e-12 Monocyte count; CESC cis rs6866344 0.697 rs62392833 chr5:178135452 T/A cg10224037 chr5:178157518 ZNF354A 0.69 7.77 0.43 1.78e-13 Neutrophil percentage of white cells; CESC cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg03433033 chr1:76189801 ACADM 0.62 6.27 0.36 1.49e-9 Blood metabolite levels;Acylcarnitine levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21173440 chr5:55008212 SLC38A9 -0.43 -6.94 -0.39 3.01e-11 Gambling; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09508119 chr19:506588 C19orf20 -0.49 -6.68 -0.38 1.39e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9309711 0.961 rs11692184 chr2:3480710 C/T cg10845886 chr2:3471009 TTC15 -0.89 -13.07 -0.63 1.84e-30 Neurofibrillary tangles; CESC cis rs1003719 0.762 rs1155786 chr21:38448025 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.48 0.46 1.55e-15 Eye color traits; CESC cis rs7927771 1.000 rs11039255 chr11:47495746 G/T cg05585544 chr11:47624801 NA -0.53 -7.99 -0.44 4.29e-14 Subjective well-being; CESC cis rs7267979 0.727 rs4815431 chr20:25532405 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -12.48 -0.61 1.93e-28 Liver enzyme levels (alkaline phosphatase); CESC cis rs7937682 1.000 rs9734135 chr11:111536190 G/A cg22437258 chr11:111473054 SIK2 0.69 9.18 0.49 1.3e-17 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13132016 chr14:58893740 KIAA0586;TIMM9 -0.57 -6.56 -0.37 2.8e-10 Gut microbiome composition (summer); CESC cis rs916888 0.697 rs199516 chr17:44856485 C/T cg27589368 chr17:43923255 LOC100128977;IMP5 0.35 5.09 0.3 6.78e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs4716602 0.596 rs10267031 chr7:156159649 A/G cg07175507 chr18:77160758 NFATC1 -0.44 -6.04 -0.35 5.07e-9 Anti-saccade response; CESC cis rs5769707 0.967 rs739248 chr22:50025205 T/C cg05373962 chr22:49881684 NA -0.39 -6.77 -0.38 8.07e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg12756686 chr19:29218302 NA 0.49 5.91 0.34 1.04e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs7829975 0.617 rs4841071 chr8:8791144 G/T cg15556689 chr8:8085844 FLJ10661 0.41 5.19 0.3 4.26e-7 Mood instability; CESC cis rs9858542 1.000 rs13085791 chr3:49721798 C/A cg07274523 chr3:49395745 GPX1 0.67 8.65 0.47 5.08e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6964587 0.967 rs10429103 chr7:91598443 T/A cg17063962 chr7:91808500 NA 0.57 7.74 0.43 2.11e-13 Breast cancer; CESC cis rs977987 0.806 rs4888418 chr16:75460306 C/G cg03315344 chr16:75512273 CHST6 0.41 5.88 0.34 1.21e-8 Dupuytren's disease; CESC cis rs10242455 0.702 rs1045012 chr7:98984354 G/C cg18809830 chr7:99032528 PTCD1 -0.89 -6.09 -0.35 3.93e-9 Blood metabolite levels; CESC cis rs2479106 0.549 rs10818851 chr9:126395781 C/A cg16191174 chr9:126692580 DENND1A 0.4 5.57 0.32 6.35e-8 Polycystic ovary syndrome; CESC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.02 11.36 0.57 1.23e-24 Platelet count; CESC cis rs765787 0.530 rs12910270 chr15:45512086 G/A cg24006582 chr15:45444508 DUOX1 0.52 6.34 0.36 9.88e-10 Uric acid levels; CESC cis rs2845885 0.793 rs56241103 chr11:63882364 C/T cg05555928 chr11:63887634 MACROD1 -0.54 -5.99 -0.35 6.69e-9 Body mass index; CESC cis rs698833 0.886 rs2053455 chr2:44550233 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.53 6.75 0.38 9.26e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27224392 chr10:104474430 SFXN2;ARL3 -0.5 -7.14 -0.4 8.8e-12 Gambling; CESC cis rs10911232 0.507 rs10911195 chr1:182993438 T/C ch.1.3577855R chr1:183094577 LAMC1 0.85 13.21 0.63 5.94e-31 Hypertriglyceridemia; CESC trans rs9561428 0.850 rs9561440 chr13:94423496 A/C cg17039369 chr21:46341006 ITGB2 0.51 6.22 0.36 1.95e-9 Bipolar disorder and schizophrenia; CESC trans rs263156 0.567 rs263127 chr6:142934867 A/G cg10648252 chr7:101469088 CUX1 -0.45 -6.13 -0.35 3.24e-9 Ear morphology;Lobe size;Lobe attachment; CESC cis rs7927771 0.697 rs11039307 chr11:47611152 C/T cg05585544 chr11:47624801 NA -0.42 -6.6 -0.38 2.29e-10 Subjective well-being; CESC cis rs1153858 1.000 rs1145081 chr15:45679667 C/G cg21132104 chr15:45694354 SPATA5L1 0.77 10.24 0.53 5.77e-21 Homoarginine levels; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.39 0.37 7.51e-10 Electroencephalogram traits; CESC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg02564969 chr6:151773285 C6orf211;RMND1 0.62 8.57 0.47 8.78e-16 Menarche (age at onset); CESC cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg19193384 chr17:30244184 NA -0.71 -6.6 -0.38 2.17e-10 Hip circumference adjusted for BMI; CESC cis rs7914558 0.966 rs2065977 chr10:104729415 C/T cg15744005 chr10:104629667 AS3MT -0.34 -5.31 -0.31 2.32e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10704137 chr6:25732153 NA -0.63 -7.44 -0.42 1.37e-12 Gut microbiome composition (summer); CESC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.74 10.2 0.53 8.14e-21 Total body bone mineral density; CESC cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg03467027 chr4:99064603 C4orf37 0.47 5.71 0.33 2.95e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.928 rs61785614 chr1:46446047 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2637266 1.000 rs1907305 chr10:78339512 C/G cg18941641 chr10:78392320 NA 0.41 7.64 0.42 4.06e-13 Pulmonary function; CESC cis rs7927771 0.524 rs4752865 chr11:47759841 G/A cg05585544 chr11:47624801 NA -0.33 -5.22 -0.31 3.66e-7 Subjective well-being; CESC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg18357526 chr6:26021779 HIST1H4A -0.75 -10.78 -0.55 1.06e-22 Intelligence (multi-trait analysis); CESC cis rs9796 0.621 rs691702 chr15:41474399 C/G cg18705301 chr15:41695430 NDUFAF1 -0.44 -6.44 -0.37 5.52e-10 Menopause (age at onset); CESC cis rs9549260 0.755 rs2721066 chr13:41156188 C/T cg21288729 chr13:41239152 FOXO1 -0.63 -8.09 -0.44 2.2e-14 Red blood cell count; CESC cis rs7584330 0.868 rs67071074 chr2:238395429 T/C cg11271282 chr2:238384023 NA 0.51 5.76 0.33 2.31e-8 Prostate cancer; CESC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 6.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg20476274 chr7:133979776 SLC35B4 0.68 9.88 0.52 8.59e-20 Mean platelet volume; CESC cis rs6733011 0.508 rs4850889 chr2:99521385 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.11 -0.3 6.13e-7 Bipolar disorder; CESC cis rs12220238 1.000 rs10824112 chr10:75969003 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.45 0.32 1.13e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs10744422 1.000 rs4759387 chr12:123377569 C/T cg22842854 chr12:123319900 HIP1R -0.62 -5.15 -0.3 5.02e-7 Schizophrenia; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg23104823 chr14:45553408 PRPF39 -0.53 -6.18 -0.35 2.39e-9 Subjective well-being; CESC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 -0.45 -5.71 -0.33 2.99e-8 Tonsillectomy; CESC cis rs6690583 0.697 rs10782537 chr1:85484473 C/T cg22153463 chr1:85462885 MCOLN2 -0.8 -10.46 -0.54 1.2e-21 Serum sulfate level; CESC cis rs5771242 0.518 rs5771258 chr22:50675648 C/A cg08875078 chr22:50639485 SELO 0.47 5.49 0.32 9.18e-8 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC cis rs1538970 0.816 rs3790583 chr1:45956828 C/G cg06784218 chr1:46089804 CCDC17 0.37 5.9 0.34 1.11e-8 Platelet count; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg10446143 chr21:44394730 PKNOX1 -0.48 -6.55 -0.37 2.97e-10 Height; CESC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg09365446 chr1:150670422 GOLPH3L 0.39 5.24 0.31 3.25e-7 Melanoma; CESC cis rs1707322 1.000 rs1707338 chr1:46511981 T/G cg05343316 chr1:45956843 TESK2 -0.44 -5.44 -0.32 1.2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9916302 0.904 rs1619021 chr17:37739274 G/A cg20243544 chr17:37824526 PNMT 0.56 6.79 0.38 7.35e-11 Glomerular filtration rate (creatinine); CESC cis rs561341 0.714 rs547473 chr17:30297560 T/G cg00745463 chr17:30367425 LRRC37B -0.7 -7.02 -0.4 1.85e-11 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10015802 chr19:3492440 DOHH -0.59 -6.78 -0.38 7.97e-11 Gut microbiome composition (summer); CESC cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg18196295 chr10:418757 DIP2C 0.53 7.05 0.4 1.55e-11 Psychosis in Alzheimer's disease; CESC cis rs6582630 0.502 rs11181475 chr12:38348922 G/A cg26384229 chr12:38710491 ALG10B 0.69 10.42 0.54 1.6e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg00784671 chr22:46762841 CELSR1 -0.48 -5.51 -0.32 8.51e-8 LDL cholesterol;Cholesterol, total; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg09431544 chr19:14629187 DNAJB1 -0.45 -6.54 -0.37 3.17e-10 Breast cancer; CESC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg13918804 chr1:2043761 PRKCZ 0.27 5.32 0.31 2.19e-7 Height; CESC cis rs7582720 1.000 rs72926794 chr2:203827432 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs10927875 0.632 rs904911 chr1:16126932 C/T cg05821634 chr1:16164109 FLJ37453 0.35 5.04 0.3 8.77e-7 Dilated cardiomyopathy; CESC cis rs2730245 0.563 rs2709857 chr7:158685257 T/C cg24397884 chr7:158709396 WDR60 0.68 9.92 0.52 6.27e-20 Height; CESC cis rs1355223 0.583 rs2941060 chr11:34879154 G/A cg11058730 chr11:34937778 PDHX;APIP 0.83 12.7 0.62 3.47e-29 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg12564285 chr5:131593104 PDLIM4 -0.37 -5.43 -0.32 1.3e-7 Breast cancer; CESC cis rs863345 0.604 rs7555174 chr1:158487426 A/G cg12129480 chr1:158549410 OR10X1 -0.35 -6.98 -0.39 2.34e-11 Pneumococcal bacteremia; CESC cis rs8070463 0.515 rs11655943 chr17:45385640 A/G cg08085267 chr17:45401833 C17orf57 -0.5 -6.48 -0.37 4.54e-10 Multiple sclerosis;Ankylosing spondylitis; CESC cis rs7851660 0.594 rs28703314 chr9:100660145 A/T cg13688889 chr9:100608707 NA -0.62 -8.45 -0.46 2.02e-15 Strep throat; CESC cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg17366294 chr4:99064904 C4orf37 0.54 7.1 0.4 1.11e-11 Colonoscopy-negative controls vs population controls; CESC cis rs523522 0.962 rs651627 chr12:121009198 C/T cg12219531 chr12:120966889 COQ5 0.74 9.78 0.51 1.75e-19 High light scatter reticulocyte count; CESC trans rs9467711 0.606 rs71557334 chr6:26365913 G/T cg06606381 chr12:133084897 FBRSL1 -0.76 -6.82 -0.39 6.01e-11 Autism spectrum disorder or schizophrenia; CESC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg03709012 chr19:19516395 GATAD2A 1.0 15.34 0.69 1.87e-38 Tonsillectomy; CESC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg06453172 chr10:134556979 INPP5A -0.42 -5.32 -0.31 2.19e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7084402 1.000 rs12250013 chr10:60265957 C/A cg07615347 chr10:60278583 BICC1 -0.57 -8.73 -0.47 2.84e-16 Refractive error; CESC cis rs7631605 0.905 rs6764444 chr3:37173715 T/C cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.21 -0.3 3.82e-7 Cerebrospinal P-tau181p levels; CESC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.14 -0.3 5.22e-7 Lung cancer; CESC cis rs8017423 1.000 rs10129210 chr14:90668379 G/T cg14092571 chr14:90743983 NA -0.57 -8.45 -0.46 1.97e-15 Mortality in heart failure; CESC cis rs9549328 0.800 rs9549620 chr13:113633421 T/A cg22951483 chr13:113628068 MCF2L -0.35 -5.14 -0.3 5.44e-7 Systolic blood pressure; CESC cis rs9682041 0.627 rs34392658 chr3:170091584 C/T cg11886554 chr3:170076028 SKIL 0.56 5.64 0.33 4.46e-8 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00781875 chr1:156252398 TMEM79;SMG5 -0.46 -6.33 -0.36 1.02e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2658782 0.756 rs3019205 chr11:93109553 A/G cg15737290 chr11:93063684 CCDC67 0.52 6.75 0.38 9.51e-11 Pulmonary function decline; CESC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg00310523 chr12:86230176 RASSF9 0.42 6.27 0.36 1.47e-9 Major depressive disorder; CESC trans rs629535 0.767 rs72654073 chr8:70081231 G/A cg21567404 chr3:27674614 NA -0.88 -10.28 -0.53 4.4e-21 Dupuytren's disease; CESC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg16049864 chr8:95962084 TP53INP1 -0.67 -12.02 -0.59 7.22e-27 Type 2 diabetes; CESC cis rs10242455 0.681 rs2687140 chr7:99322342 T/C cg07715041 chr7:99302981 CYP3A7 -0.44 -5.48 -0.32 9.91e-8 Blood metabolite levels; CESC cis rs524023 1.000 rs10897518 chr11:64360705 A/G cg07220939 chr11:64358617 SLC22A12 0.35 5.35 0.31 1.89e-7 Urate levels in obese individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01823416 chr1:47082372 MOBKL2C 0.61 7.86 0.43 9.4e-14 Gut microbiome composition (summer); CESC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg23131131 chr22:24373011 LOC391322 -0.55 -6.36 -0.36 8.84e-10 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC trans rs1728785 0.818 rs11648503 chr16:68598938 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.71 8.43 0.46 2.17e-15 Ulcerative colitis; CESC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg23161317 chr6:28129485 ZNF389 0.49 6.2 0.36 2.14e-9 Parkinson's disease; CESC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg24829409 chr8:58192753 C8orf71 -0.65 -7.84 -0.43 1.13e-13 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12647895 chr7:6629806 C7orf26 0.59 6.71 0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs6964587 1.000 rs12533199 chr7:91757393 C/T cg17063962 chr7:91808500 NA 0.59 8.13 0.45 1.69e-14 Breast cancer; CESC cis rs644799 0.710 rs519511 chr11:95538270 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.76 10.93 0.56 3.47e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7089973 0.624 rs11196930 chr10:116583596 C/T cg03647239 chr10:116582469 FAM160B1 0.42 5.13 0.3 5.71e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg19774624 chr17:42201019 HDAC5 -0.7 -10.17 -0.53 1.03e-20 Total body bone mineral density; CESC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg11663144 chr21:46675770 NA -0.55 -8.58 -0.47 8.14e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg21770322 chr7:97807741 LMTK2 0.54 8.13 0.45 1.67e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs4803468 0.967 rs3213860 chr19:41920211 T/C cg14132834 chr19:41945861 ATP5SL -0.67 -8.23 -0.45 8.57e-15 Height; CESC cis rs140365914 1 rs140365914 chr7:155106570 C/T cg04811098 chr7:155088454 INSIG1 0.4 5.91 0.34 1.04e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg05340658 chr4:99064831 C4orf37 0.82 12.87 0.62 9.38e-30 Colonoscopy-negative controls vs population controls; CESC cis rs3749237 0.595 rs4855864 chr3:49521974 C/T cg06212747 chr3:49208901 KLHDC8B 0.51 6.82 0.39 6.09e-11 Resting heart rate; CESC cis rs7267979 0.966 rs2257705 chr20:25264664 T/C cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg03433033 chr1:76189801 ACADM -0.57 -5.87 -0.34 1.28e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1559088 0.576 rs10407255 chr19:33581150 A/G cg03563238 chr19:33554763 RHPN2 0.34 6.55 0.37 3.04e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9287719 1.000 rs9287719 chr2:10710730 C/T cg02196655 chr2:10830764 NOL10 -0.36 -5.42 -0.32 1.31e-7 Prostate cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25789201 chr7:72395803 POM121 0.51 6.58 0.37 2.45e-10 Gut microbiota (bacterial taxa); CESC cis rs1941023 0.503 rs4528348 chr11:60129505 C/G cg08716584 chr11:60157161 MS4A7 -0.51 -8.14 -0.45 1.5e-14 Congenital heart disease (maternal effect); CESC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg25319279 chr11:5960081 NA -0.36 -5.32 -0.31 2.19e-7 DNA methylation (variation); CESC cis rs1577917 0.771 rs12205013 chr6:86333029 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.54 -7.38 -0.41 2.02e-12 Response to antipsychotic treatment; CESC cis rs3925075 1.000 rs9674009 chr16:31347541 C/A cg02846316 chr16:31340340 ITGAM 0.41 6.52 0.37 3.54e-10 IgA nephropathy; CESC cis rs113835537 0.529 rs2279864 chr11:66247844 G/A cg22134325 chr11:66188745 NPAS4 0.35 5.47 0.32 1.05e-7 Airway imaging phenotypes; CESC cis rs637571 0.544 rs500161 chr11:65695438 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 9.97 0.52 4.4e-20 Eosinophil percentage of white cells; CESC cis rs3806843 1.000 rs1548700 chr5:140164889 A/T cg26395211 chr5:140044315 WDR55 -0.42 -5.31 -0.31 2.31e-7 Depressive symptoms (multi-trait analysis); CESC cis rs4555082 0.874 rs4677 chr14:105717279 T/C cg06808227 chr14:105710500 BRF1 -0.62 -7.35 -0.41 2.46e-12 Mean platelet volume;Platelet distribution width; CESC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.78 0.65 6.16e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9916302 0.851 rs9904919 chr17:37556431 G/C cg00129232 chr17:37814104 STARD3 0.59 7.96 0.44 5.17e-14 Glomerular filtration rate (creatinine); CESC cis rs7098414 0.511 rs10887826 chr10:82151380 C/T cg00277334 chr10:82204260 NA -0.5 -7.52 -0.42 8.74e-13 Post bronchodilator FEV1; CESC cis rs3126085 0.935 rs11204967 chr1:152249720 A/G cg17718321 chr1:152188247 HRNR 0.39 5.2 0.3 3.97e-7 Atopic dermatitis; CESC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs9486715 0.838 rs7770889 chr6:96858453 C/T cg06623918 chr6:96969491 KIAA0776 -0.76 -10.72 -0.55 1.62e-22 Headache; CESC cis rs12142240 0.698 rs1475390 chr1:46816340 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13654451 chr1:235267828 NA -0.49 -6.11 -0.35 3.47e-9 Ulcerative colitis; CESC cis rs7267979 0.932 rs6037125 chr20:25463382 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.73 13.15 0.63 9.54e-31 Liver enzyme levels (alkaline phosphatase); CESC cis rs11098499 0.618 rs35265692 chr4:120325135 T/C cg09307838 chr4:120376055 NA 0.93 12.87 0.62 9.12e-30 Corneal astigmatism; CESC cis rs7680126 0.500 rs4697933 chr4:10146493 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -6.41 -0.37 6.65e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs6987853 0.787 rs2923441 chr8:42429937 G/T cg09913449 chr8:42400586 C8orf40 -0.46 -7.64 -0.42 4.02e-13 Mean corpuscular hemoglobin concentration; CESC cis rs6570726 0.967 rs418662 chr6:145848832 A/C cg05347473 chr6:146136440 FBXO30 0.44 5.95 0.34 8.32e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg19077165 chr18:44547161 KATNAL2 0.65 9.96 0.52 4.76e-20 Personality dimensions; CESC cis rs11098499 0.909 rs1546504 chr4:120241179 C/T cg24375607 chr4:120327624 NA 0.45 5.5 0.32 8.75e-8 Corneal astigmatism; CESC cis rs1949733 0.701 rs940134 chr4:8454870 C/T cg11789530 chr4:8429930 ACOX3 0.76 11.12 0.56 8.15e-24 Response to antineoplastic agents; CESC cis rs4835473 0.868 rs35809032 chr4:144745950 G/A cg25736465 chr4:144833511 NA -0.46 -6.98 -0.39 2.36e-11 Immature fraction of reticulocytes; CESC cis rs2730245 1.000 rs2527199 chr7:158737113 G/A cg24397884 chr7:158709396 WDR60 -0.88 -13.48 -0.64 6.6e-32 Height; CESC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.67 0.33 3.77e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg08061076 chr7:1943177 MAD1L1 -0.38 -5.06 -0.3 7.92e-7 Bipolar disorder and schizophrenia; CESC cis rs2645694 0.626 rs2703126 chr4:77819842 T/C cg18351406 chr4:77819688 ANKRD56 0.55 6.85 0.39 5.11e-11 Emphysema distribution in smoking; CESC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg17724175 chr1:150552817 MCL1 0.44 7.21 0.4 6.02e-12 Tonsillectomy; CESC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg22143856 chr6:28129313 ZNF389 0.42 5.26 0.31 2.91e-7 Parkinson's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27432331 chr16:30544242 ZNF747 0.49 6.73 0.38 1.02e-10 Fibrinogen levels; CESC trans rs7246657 0.943 rs3803895 chr19:37898669 A/G cg24637308 chr11:6592297 DNHD1 0.54 6.32 0.36 1.11e-9 Coronary artery calcification; CESC cis rs7618915 0.679 rs6802320 chr3:52241835 T/C cg07507251 chr3:52567010 NT5DC2 0.34 5.43 0.32 1.25e-7 Bipolar disorder; CESC cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9549367 0.789 rs9549718 chr13:113909822 A/G cg00898013 chr13:113819073 PROZ -0.54 -7.44 -0.42 1.39e-12 Platelet distribution width; CESC cis rs10089 1.000 rs4836367 chr5:127482592 A/G cg19767477 chr5:127420684 SLC12A2 -0.39 -5.18 -0.3 4.42e-7 Ileal carcinoids; CESC cis rs7085104 0.591 rs4919683 chr10:104585125 G/T cg04362960 chr10:104952993 NT5C2 0.47 6.44 0.37 5.49e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg20151795 chr6:28129481 ZNF389 0.39 5.18 0.3 4.42e-7 Depression; CESC cis rs6460942 0.591 rs10262667 chr7:12385391 C/T cg06484146 chr7:12443880 VWDE -0.54 -7.57 -0.42 6.23e-13 Coronary artery disease; CESC cis rs920590 0.758 rs1817836 chr8:19664852 T/C cg01411142 chr8:19674711 INTS10 0.52 5.92 0.34 1.01e-8 Acute lymphoblastic leukemia (childhood); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27131607 chr17:61851115 DDX42;CCDC47 -0.46 -6.27 -0.36 1.44e-9 Gut microbiota (bacterial taxa); CESC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg06558623 chr16:89946397 TCF25 1.13 8.87 0.48 1.08e-16 Skin colour saturation; CESC cis rs72781680 1.000 rs17711825 chr2:24124578 A/G cg08917208 chr2:24149416 ATAD2B 0.91 8.18 0.45 1.18e-14 Lymphocyte counts; CESC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg04944784 chr2:26401820 FAM59B -0.68 -7.66 -0.43 3.59e-13 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01565083 chr17:80042523 FASN 0.48 6.69 0.38 1.3e-10 Fibrinogen levels; CESC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg05457628 chr5:178986728 RUFY1 0.57 8.63 0.47 5.81e-16 Lung cancer; CESC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg13733410 chr7:12443478 VWDE -0.5 -6.01 -0.35 6.23e-9 Coronary artery disease; CESC cis rs2074585 0.806 rs2657949 chr15:90950790 G/A cg10434728 chr15:90938212 IQGAP1 0.42 7.71 0.43 2.57e-13 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs11645898 0.872 rs4788459 chr16:72153125 C/G cg14768367 chr16:72042858 DHODH -0.69 -5.92 -0.34 1.02e-8 Blood protein levels; CESC cis rs870825 0.860 rs72689277 chr4:185593699 G/A cg04058563 chr4:185651563 MLF1IP 0.57 5.29 0.31 2.54e-7 Blood protein levels; CESC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg13944838 chr5:179740914 GFPT2 -0.73 -9.73 -0.51 2.49e-19 Height; CESC cis rs10883723 0.962 rs10883726 chr10:104236276 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.67 -0.33 3.77e-8 Allergic disease (asthma, hay fever or eczema); CESC trans rs4471313 0.955 rs6427242 chr1:170288157 C/G cg14876685 chr7:99177937 NA 0.41 6.27 0.36 1.5e-9 Waist-hip ratio; CESC cis rs4919087 0.851 rs2297987 chr10:98989454 C/T cg25902810 chr10:99078978 FRAT1 -0.58 -8.11 -0.45 1.93e-14 Monocyte count; CESC cis rs8177253 0.511 rs9830001 chr3:133433470 A/G cg24879335 chr3:133465180 TF -0.3 -5.23 -0.31 3.37e-7 Iron status biomarkers; CESC cis rs8072100 0.935 rs8070759 chr17:45638760 C/T cg08085267 chr17:45401833 C17orf57 0.41 5.3 0.31 2.46e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1018836 0.631 rs9987164 chr8:91470910 T/G cg16814680 chr8:91681699 NA -0.52 -6.92 -0.39 3.38e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs738322 0.934 rs84473 chr22:38557326 T/C cg25457927 chr22:38595422 NA -0.3 -5.56 -0.32 6.47e-8 Cutaneous nevi; CESC cis rs9488822 0.676 rs1338667 chr6:116323910 T/A cg15226275 chr6:116381976 FRK 0.25 6.22 0.36 1.94e-9 Cholesterol, total;LDL cholesterol; CESC cis rs16917546 0.933 rs10995238 chr10:64387108 A/G cg03961010 chr10:64397487 ZNF365 0.38 6.1 0.35 3.66e-9 Basal cell carcinoma; CESC cis rs7103648 0.864 rs10769264 chr11:47423340 C/T cg03711944 chr11:47377212 SPI1 -0.31 -5.04 -0.3 8.72e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs2072732 0.861 rs10489589 chr1:2951244 T/C cg03976712 chr1:2946727 NA 0.33 5.45 0.32 1.17e-7 Plateletcrit; CESC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg18230493 chr5:56204884 C5orf35 -0.74 -9.11 -0.49 2.05e-17 Initial pursuit acceleration; CESC cis rs9486715 1.000 rs3798297 chr6:97062835 C/T cg06623918 chr6:96969491 KIAA0776 -0.89 -13.28 -0.63 3.27e-31 Headache; CESC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg25072359 chr17:41440525 NA 0.47 6.25 0.36 1.66e-9 Menopause (age at onset); CESC cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg19912559 chr1:40204330 PPIE 0.39 5.85 0.34 1.42e-8 Blood protein levels; CESC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg11663144 chr21:46675770 NA -0.63 -10.0 -0.52 3.38e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs698833 0.926 rs786620 chr2:44595803 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.95 0.34 8.29e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs763014 0.898 rs8060585 chr16:635794 C/G cg00802000 chr16:706648 WDR90 -0.41 -6.19 -0.36 2.26e-9 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09724427 chr17:47866462 MYST2 0.47 6.09 0.35 4.05e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.694 rs5751107 chr22:41857812 A/G cg06481639 chr22:41940642 POLR3H 0.64 6.5 0.37 3.86e-10 Vitiligo; CESC cis rs7772486 0.774 rs6930181 chr6:146180974 A/T cg05347473 chr6:146136440 FBXO30 -0.44 -6.1 -0.35 3.81e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs6088580 0.634 rs6058041 chr20:33018008 A/G cg06115741 chr20:33292138 TP53INP2 0.47 6.03 0.35 5.34e-9 Glomerular filtration rate (creatinine); CESC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg15445000 chr17:37608096 MED1 0.39 6.46 0.37 4.99e-10 Glomerular filtration rate (creatinine); CESC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg00149659 chr3:10157352 C3orf10 0.71 8.3 0.45 5.44e-15 Alzheimer's disease; CESC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg23161317 chr6:28129485 ZNF389 -0.52 -6.6 -0.38 2.28e-10 Parkinson's disease; CESC cis rs2635047 0.682 rs9960932 chr18:44792445 C/T cg24371990 chr18:44770781 NA 0.39 6.26 0.36 1.5e-9 Educational attainment; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20861091 chr8:144881744 SCRIB -0.43 -6.22 -0.36 1.95e-9 Gut microbiota (bacterial taxa); CESC cis rs11690935 1.000 rs1554166 chr2:172541609 G/T cg13550731 chr2:172543902 DYNC1I2 -0.96 -15.12 -0.68 1.19e-37 Schizophrenia; CESC cis rs9388451 0.559 rs1777210 chr6:126098916 T/G cg05901451 chr6:126070800 HEY2 -0.57 -8.3 -0.45 5.53e-15 Brugada syndrome; CESC cis rs9611565 1.000 rs1109151 chr22:41752944 A/G cg06481639 chr22:41940642 POLR3H -0.46 -5.28 -0.31 2.7e-7 Vitiligo; CESC cis rs2228479 0.850 rs1800331 chr16:89858417 C/A cg06558623 chr16:89946397 TCF25 1.18 9.47 0.5 1.65e-18 Skin colour saturation; CESC cis rs9303280 0.806 rs10852935 chr17:38031674 C/T cg20243544 chr17:37824526 PNMT 0.53 6.93 0.39 3.14e-11 Self-reported allergy; CESC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Parkinson's disease; CESC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg18876405 chr7:65276391 NA -0.55 -7.48 -0.42 1.12e-12 Aortic root size; CESC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.33 -0.31 2.09e-7 Height; CESC cis rs11098499 0.909 rs10020034 chr4:120294331 A/G cg09307838 chr4:120376055 NA 0.94 12.84 0.62 1.16e-29 Corneal astigmatism; CESC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.5 -6.67 -0.38 1.5e-10 Menarche (age at onset); CESC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg25985355 chr7:65971099 NA 0.32 5.26 0.31 3e-7 Aortic root size; CESC cis rs4523957 0.928 rs1122645 chr17:2170858 A/G cg16513277 chr17:2031491 SMG6 -0.59 -8.01 -0.44 3.63e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs8067545 0.611 rs11868116 chr17:20029593 T/C cg13482628 chr17:19912719 NA 0.4 5.4 0.31 1.47e-7 Schizophrenia; CESC cis rs6484504 0.576 rs58702363 chr11:31246397 C/A cg14844989 chr11:31128820 NA -0.38 -5.46 -0.32 1.11e-7 Red blood cell count; CESC cis rs2859741 1.000 rs543121 chr1:37497098 T/C cg09363841 chr1:37513479 NA -0.67 -10.66 -0.55 2.62e-22 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs7582720 1.000 rs76890136 chr2:203850011 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg01448562 chr3:133502909 NA -0.42 -5.9 -0.34 1.09e-8 Iron status biomarkers; CESC cis rs3820068 0.532 rs72647105 chr1:15935238 C/G cg16988262 chr1:15930761 NA 0.34 5.52 0.32 7.98e-8 Systolic blood pressure; CESC cis rs1941023 0.584 rs6591578 chr11:60158649 G/A cg08716584 chr11:60157161 MS4A7 -0.53 -8.05 -0.44 2.73e-14 Congenital heart disease (maternal effect); CESC cis rs1957429 0.520 rs230723 chr14:65316017 C/T cg23373153 chr14:65346875 NA -0.71 -5.43 -0.32 1.25e-7 Pediatric areal bone mineral density (radius); CESC cis rs6835098 0.608 rs2332668 chr4:174163360 A/G cg08422745 chr4:174089978 GALNT7 -0.72 -10.33 -0.54 3.09e-21 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs2228479 0.702 rs62056087 chr16:89920383 C/A cg00800038 chr16:89945340 TCF25 -0.91 -6.93 -0.39 3.21e-11 Skin colour saturation; CESC cis rs1348850 0.914 rs6761593 chr2:178451600 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.56 -7.53 -0.42 7.83e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6088580 0.602 rs6058064 chr20:33086622 A/G cg06115741 chr20:33292138 TP53INP2 0.44 5.69 0.33 3.34e-8 Glomerular filtration rate (creatinine); CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg27094323 chr7:1216898 NA -0.43 -5.92 -0.34 1.02e-8 Longevity;Endometriosis; CESC trans rs2121875 0.667 rs1823252 chr5:44233661 A/G cg09056876 chr6:156718398 NA -0.48 -6.0 -0.35 6.34e-9 Prostate cancer; CESC cis rs9322193 0.961 rs9027 chr6:149916057 T/A cg07701084 chr6:150067640 NUP43 0.4 5.47 0.32 1.02e-7 Lung cancer; CESC cis rs1832871 0.711 rs9459887 chr6:158696479 C/T cg07165851 chr6:158734300 TULP4 0.58 6.25 0.36 1.63e-9 Height; CESC cis rs2243480 1.000 rs313809 chr7:65499983 G/A cg18252515 chr7:66147081 NA -1.26 -12.38 -0.61 4.54e-28 Diabetic kidney disease; CESC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg24209194 chr3:40518798 ZNF619 0.5 6.12 0.35 3.3e-9 Renal cell carcinoma; CESC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg18876405 chr7:65276391 NA -0.49 -6.65 -0.38 1.64e-10 Aortic root size; CESC trans rs1814175 0.692 rs1851873 chr11:49937767 A/G cg03929089 chr4:120376271 NA -0.72 -9.28 -0.5 6.08e-18 Height; CESC cis rs11577318 0.853 rs11247913 chr1:26648551 G/C cg00852783 chr1:26633632 UBXN11 0.49 6.75 0.38 9.16e-11 Granulocyte percentage of myeloid white cells; CESC cis rs4319547 0.698 rs10744217 chr12:122942070 A/G cg05707623 chr12:122985044 ZCCHC8 -0.53 -6.52 -0.37 3.46e-10 Body mass index; CESC cis rs2607426 0.681 rs2607418 chr19:41257396 A/G cg09128733 chr19:41633906 CYP2F1 -0.81 -5.21 -0.3 3.83e-7 Blood protein levels; CESC cis rs10504229 0.679 rs4738574 chr8:58033771 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -5.93 -0.34 9.43e-9 Developmental language disorder (linguistic errors); CESC cis rs2629540 0.824 rs10901809 chr10:126410804 C/T cg08799069 chr10:126477246 METTL10 0.49 6.66 0.38 1.59e-10 Cocaine dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03565437 chr5:14488482 TRIO -0.73 -8.42 -0.46 2.41e-15 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs6570736 chr6:146388320 C/T cg05347473 chr6:146136440 FBXO30 0.51 6.73 0.38 1.08e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg18758796 chr5:131593413 PDLIM4 0.46 6.59 0.38 2.35e-10 Breast cancer; CESC cis rs10851478 0.872 rs11858411 chr15:49791951 A/G cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16355531 chr10:126370306 FAM53B -0.48 -6.11 -0.35 3.56e-9 Gut microbiota (bacterial taxa); CESC cis rs5753618 0.504 rs9606847 chr22:31901789 G/C cg00478049 chr22:31556069 RNF185 -0.46 -5.53 -0.32 7.55e-8 Colorectal cancer; CESC cis rs7818345 0.967 rs4921638 chr8:19274793 C/A cg11303988 chr8:19266685 CSGALNACT1 0.34 6.25 0.36 1.64e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg17509989 chr5:176798049 RGS14 0.48 5.78 0.33 2.12e-8 Hemoglobin concentration;Hematocrit; CESC cis rs4664293 0.967 rs7597488 chr2:160547096 T/G cg08347373 chr2:160653686 CD302 -0.31 -5.09 -0.3 6.83e-7 Monocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03115081 chr17:74722049 C17orf95;JMJD6 0.49 6.65 0.38 1.65e-10 Gut microbiota (bacterial taxa); CESC cis rs2439831 0.850 rs12101756 chr15:44053887 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.78 0.38 7.96e-11 Lung cancer in ever smokers; CESC cis rs896854 0.517 rs1011796 chr8:95951273 A/G cg13393036 chr8:95962371 TP53INP1 0.46 8.21 0.45 9.85e-15 Type 2 diabetes; CESC cis rs8133932 0.654 rs375971 chr21:47338854 C/G cg14185626 chr21:47401492 COL6A1 -0.46 -5.12 -0.3 6.01e-7 Schizophrenia; CESC cis rs921968 0.565 rs6704575 chr2:219589594 C/T cg02176678 chr2:219576539 TTLL4 0.44 7.65 0.43 3.76e-13 Mean corpuscular hemoglobin concentration; CESC cis rs9287719 0.967 rs728282 chr2:10750303 A/G cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs67478160 0.619 rs12878682 chr14:104233627 G/C cg01849466 chr14:104193079 ZFYVE21 -0.5 -6.89 -0.39 4.13e-11 Schizophrenia; CESC cis rs1707322 1.000 rs4660905 chr1:46461587 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.63 -0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13453711 chr1:212482804 PPP2R5A -0.73 -8.6 -0.47 6.97e-16 Gut microbiome composition (summer); CESC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg18016565 chr1:150552671 MCL1 -0.35 -5.22 -0.31 3.62e-7 Urate levels; CESC cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg24818145 chr4:99064322 C4orf37 0.4 5.08 0.3 7.27e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8062405 1.000 rs61737565 chr16:28855522 G/C cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7945705 0.783 rs11042125 chr11:8938049 A/T cg21881798 chr11:8931708 C11orf17;ST5 -0.52 -8.56 -0.47 9.57e-16 Hemoglobin concentration; CESC cis rs2760061 0.655 rs686533 chr1:228119604 A/G cg01973587 chr1:228161476 NA 0.37 5.71 0.33 3.03e-8 Diastolic blood pressure; CESC cis rs7223966 1.000 rs8073373 chr17:61703320 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.42 0.41 1.61e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg18301423 chr5:131593218 PDLIM4 0.38 5.23 0.31 3.38e-7 Acylcarnitine levels; CESC cis rs2645694 0.626 rs2703143 chr4:77830441 A/G cg18351406 chr4:77819688 ANKRD56 0.53 6.34 0.36 9.71e-10 Emphysema distribution in smoking; CESC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.1 -0.3 6.6e-7 Developmental language disorder (linguistic errors); CESC cis rs1728785 1.000 rs1645938 chr16:68595197 G/A cg02972257 chr16:68554789 NA -0.59 -6.7 -0.38 1.23e-10 Ulcerative colitis; CESC cis rs10781543 0.845 rs10781542 chr9:139327439 A/G cg14169450 chr9:139327907 INPP5E 0.53 8.12 0.45 1.79e-14 Monocyte percentage of white cells; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg16145915 chr7:1198662 ZFAND2A -0.81 -14.46 -0.66 2.47e-35 Longevity;Endometriosis; CESC cis rs4233802 1.000 rs4362583 chr2:151149715 A/G cg25300694 chr2:151184358 NA 0.94 6.47 0.37 4.75e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs6598955 0.640 rs1577507 chr1:26547179 C/T cg00852783 chr1:26633632 UBXN11 0.43 6.34 0.36 9.72e-10 Obesity-related traits; CESC cis rs10979 0.571 rs6909701 chr6:143922918 C/G cg25407410 chr6:143891975 LOC285740 -0.47 -5.86 -0.34 1.4e-8 Hypospadias; CESC cis rs3806843 0.735 rs809635 chr5:140081791 A/G cg16179182 chr5:140090404 VTRNA1-1 0.4 5.14 0.3 5.34e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9611519 0.603 rs4821999 chr22:41470001 A/G cg03806693 chr22:41940476 POLR3H -0.43 -5.22 -0.31 3.67e-7 Neuroticism; CESC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg21770322 chr7:97807741 LMTK2 0.61 9.17 0.49 1.4e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs11168351 0.864 rs12228750 chr12:48496997 G/A cg04545296 chr12:48745243 ZNF641 -0.33 -5.65 -0.33 4.11e-8 Bipolar disorder and schizophrenia; CESC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg17294928 chr15:75287854 SCAMP5 0.49 6.53 0.37 3.31e-10 Breast cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20163463 chr17:1171417 NA 0.47 6.06 0.35 4.64e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.6 0.33 5.36e-8 Menopause (age at onset); CESC cis rs9457247 0.765 rs9295385 chr6:167448181 A/G cg07741184 chr6:167504864 NA 0.37 5.81 0.34 1.76e-8 Crohn's disease; CESC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg18876405 chr7:65276391 NA -0.51 -6.96 -0.39 2.71e-11 Aortic root size; CESC cis rs6570726 0.846 rs6570700 chr6:145931552 A/G cg23711669 chr6:146136114 FBXO30 0.87 12.93 0.62 5.52e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs4253772 0.515 rs8142080 chr22:46647429 G/T cg18190219 chr22:46762943 CELSR1 -0.52 -5.08 -0.3 7.06e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7089973 0.584 rs4752322 chr10:116613258 A/C cg03647239 chr10:116582469 FAM160B1 0.47 6.04 0.35 5.08e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9300255 0.506 rs11057251 chr12:123791227 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.34 5.44 0.32 1.2e-7 Neutrophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05612325 chr17:14110411 COX10 0.47 6.08 0.35 4.2e-9 Fibrinogen levels; CESC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg09177884 chr7:1199841 ZFAND2A -0.52 -6.93 -0.39 3.29e-11 Longevity;Endometriosis; CESC cis rs7833790 0.929 rs10958048 chr8:82792914 C/T cg17211192 chr8:82754475 SNX16 0.71 8.69 0.47 3.72e-16 Diastolic blood pressure; CESC cis rs7208859 0.673 rs216418 chr17:28936537 G/A cg14008862 chr17:28927542 LRRC37B2 0.69 6.31 0.36 1.18e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1003719 0.679 rs2835674 chr21:38581522 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.07 -0.44 2.45e-14 Eye color traits; CESC trans rs1945213 0.659 rs11227133 chr11:55836620 T/C cg15704280 chr7:45808275 SEPT13 0.76 7.31 0.41 3.15e-12 Acute lymphoblastic leukemia (childhood); CESC trans rs17685 0.725 rs6947068 chr7:75662056 T/C cg19862616 chr7:65841803 NCRNA00174 -0.86 -12.7 -0.62 3.41e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs72772090 0.539 rs13601 chr5:96110596 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.03 -0.3 8.86e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8020095 0.528 rs1950281 chr14:67401299 T/G cg19548862 chr14:67692701 FAM71D -0.48 -5.76 -0.33 2.34e-8 Depression (quantitative trait); CESC cis rs9790314 0.846 rs4560315 chr3:160982132 G/T cg03342759 chr3:160939853 NMD3 -0.51 -7.39 -0.41 1.96e-12 Morning vs. evening chronotype; CESC cis rs6087990 0.965 rs2424903 chr20:31349315 C/T cg13636640 chr20:31349939 DNMT3B 0.91 16.02 0.7 7.23e-41 Ulcerative colitis; CESC cis rs4722166 0.630 rs4722169 chr7:22785419 C/T cg05265849 chr7:22767390 IL6 0.57 7.08 0.4 1.31e-11 Lung cancer; CESC trans rs9858542 0.953 rs6766131 chr3:49538932 T/C cg21659725 chr3:3221576 CRBN -0.54 -6.37 -0.36 8.2e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs501120 1.000 rs687175 chr10:44751910 C/T cg09554077 chr10:44749378 NA -0.54 -7.18 -0.4 7.09e-12 Coronary artery disease;Coronary heart disease; CESC cis rs8016982 0.633 rs55822231 chr14:81708677 C/T cg01989461 chr14:81687754 GTF2A1 0.74 11.73 0.58 7.18e-26 Schizophrenia; CESC cis rs6460942 1.000 rs75333414 chr7:12303829 T/A cg20607287 chr7:12443886 VWDE -0.66 -7.5 -0.42 9.8e-13 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12121965 chr21:46293563 PTTG1IP 0.57 6.7 0.38 1.27e-10 Gut microbiome composition (summer); CESC trans rs2623325 0.874 rs7631745 chr3:99115940 G/A cg19595760 chr1:25948511 MAN1C1 -0.48 -6.34 -0.36 9.63e-10 Optic cup area;Vertical cup-disc ratio; CESC cis rs1348850 0.750 rs13031008 chr2:178477114 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 6.88 0.39 4.23e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.75 0.47 2.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04536951 chr19:9268775 ZNF317 0.53 7.07 0.4 1.36e-11 Fibrinogen levels; CESC cis rs2637266 1.000 rs7477433 chr10:78358116 C/T cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs10849689 1 rs10849689 chr12:110493222 A/G cg12870014 chr12:110450643 ANKRD13A 0.83 9.41 0.5 2.42e-18 Schizophrenia; CESC cis rs7523050 0.643 rs12729998 chr1:109405505 T/C cg08274380 chr1:109419600 GPSM2 0.91 6.2 0.36 2.16e-9 Fat distribution (HIV); CESC cis rs2439831 0.850 rs7183809 chr15:44120868 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.66 6.03 0.35 5.4e-9 Lung cancer in ever smokers; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg01685689 chr11:126081170 FAM118B;RPUSD4 0.48 6.27 0.36 1.49e-9 Systemic lupus erythematosus; CESC cis rs12946454 0.521 rs66827053 chr17:43250653 A/G cg10701640 chr17:43249399 NA 0.46 8.05 0.44 2.77e-14 Systolic blood pressure; CESC cis rs12497850 0.829 rs8926 chr3:49052785 T/A cg03060546 chr3:49711283 APEH 0.51 6.28 0.36 1.37e-9 Parkinson's disease; CESC cis rs11098499 0.863 rs13140409 chr4:120503460 A/G cg24375607 chr4:120327624 NA 0.46 5.47 0.32 1.05e-7 Corneal astigmatism; CESC cis rs6912958 0.559 rs107689 chr6:88069333 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.74 11.21 0.57 4.04e-24 Monocyte percentage of white cells; CESC cis rs6964587 0.610 rs10953056 chr7:91466700 C/T cg17063962 chr7:91808500 NA 0.44 5.92 0.34 9.84e-9 Breast cancer; CESC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg23161317 chr6:28129485 ZNF389 0.51 6.63 0.38 1.85e-10 Depression; CESC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.88 -11.59 -0.58 2.19e-25 Alzheimer's disease; CESC cis rs2073499 1.000 rs57319506 chr3:50285677 T/C cg05260129 chr3:50388622 TUSC4;CYB561D2 0.71 5.57 0.32 6.37e-8 Schizophrenia; CESC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 7.87 0.44 8.81e-14 Menopause (age at onset); CESC cis rs2109514 1.000 rs3919515 chr7:116151784 C/G cg12739419 chr7:116140593 CAV2 0.36 6.5 0.37 3.97e-10 Prevalent atrial fibrillation; CESC cis rs4820539 1.000 rs5759596 chr22:23475750 G/A cg14186256 chr22:23484241 RTDR1 0.83 15.08 0.68 1.65e-37 Bone mineral density; CESC cis rs894734 0.567 rs7138907 chr12:54324576 C/T cg17410650 chr12:54324560 NA -0.53 -9.85 -0.52 1.06e-19 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24663683 chr5:39721720 NA -0.67 -7.85 -0.43 1.03e-13 Gut microbiome composition (summer); CESC cis rs7957197 0.882 rs12427353 chr12:121426901 G/C cg12635120 chr12:121345228 NA -0.37 -5.32 -0.31 2.18e-7 Type 2 diabetes; CESC cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 9.04 0.49 3.35e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1707322 0.717 rs11211161 chr1:46148138 A/C cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9303280 0.806 rs12941333 chr17:38040534 C/T cg20243544 chr17:37824526 PNMT 0.5 6.54 0.37 3.21e-10 Self-reported allergy; CESC cis rs2635047 1.000 rs9304341 chr18:44670263 G/A cg19077165 chr18:44547161 KATNAL2 -0.41 -5.64 -0.33 4.36e-8 Educational attainment; CESC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg11644478 chr21:40555479 PSMG1 -0.82 -12.21 -0.6 1.7e-27 Cognitive function; CESC cis rs6460942 0.908 rs77799203 chr7:12264432 C/G cg20607287 chr7:12443886 VWDE -0.58 -6.08 -0.35 4.2e-9 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00531924 chr6:111279890 GTF3C6 -0.43 -6.01 -0.35 6.18e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4555082 0.957 rs2816609 chr14:105720803 A/C cg13114125 chr14:105738426 BRF1 -0.65 -8.32 -0.46 4.71e-15 Mean platelet volume;Platelet distribution width; CESC cis rs11630290 0.592 rs1017531 chr15:64158650 G/A cg12036633 chr15:63758958 NA 0.45 5.34 0.31 2e-7 Iris characteristics; CESC cis rs7267979 0.816 rs409853 chr20:25506067 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.79 14.8 0.67 1.56e-36 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04067506 chr5:176943966 DDX41 0.53 6.3 0.36 1.23e-9 Gut microbiome composition (summer); CESC trans rs10463316 0.894 rs10476769 chr5:150763970 A/G cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs9926296 0.624 rs1110331 chr16:89774396 A/G cg04287289 chr16:89883240 FANCA -0.42 -5.7 -0.33 3.11e-8 Vitiligo; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04949219 chr11:64863633 C11orf2 -0.49 -6.57 -0.37 2.6e-10 Height; CESC cis rs11148252 0.553 rs9536219 chr13:53227301 C/T cg00495681 chr13:53174319 NA 0.6 8.22 0.45 8.91e-15 Lewy body disease; CESC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.96 -0.34 8.13e-9 Total body bone mineral density; CESC cis rs1401999 1.000 rs9858774 chr3:183652736 G/A cg01324343 chr3:183735012 ABCC5 0.66 14.05 0.65 7.11e-34 Anterior chamber depth; CESC cis rs3762637 0.941 rs9873842 chr3:122135331 A/T cg24169773 chr3:122142474 KPNA1 -0.51 -6.03 -0.35 5.56e-9 LDL cholesterol levels; CESC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg11494091 chr17:61959527 GH2 0.73 12.74 0.62 2.55e-29 Prudent dietary pattern; CESC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg03538708 chr1:25844672 NA -0.38 -5.8 -0.34 1.92e-8 Erythrocyte sedimentation rate; CESC cis rs962856 0.964 rs11890812 chr2:67620015 A/G cg09028215 chr2:67624308 ETAA1 -0.42 -5.68 -0.33 3.57e-8 Pancreatic cancer; CESC cis rs11098499 0.954 rs2389802 chr4:120325732 C/A cg09307838 chr4:120376055 NA 0.94 13.61 0.64 2.45e-32 Corneal astigmatism; CESC cis rs9303401 0.659 rs34426768 chr17:56683385 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.0 11.58 0.58 2.27e-25 Cognitive test performance; CESC cis rs1534166 0.647 rs1464937 chr3:133536655 C/G cg27366882 chr3:133540807 NA -0.27 -5.28 -0.31 2.65e-7 Alcohol consumption (transferrin glycosylation); CESC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg05564831 chr3:52568323 NT5DC2 0.46 6.98 0.39 2.33e-11 Bipolar disorder; CESC cis rs12042938 0.935 rs751229 chr1:231768539 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 6.18 0.35 2.45e-9 Neuranatomic and neurocognitive phenotypes; CESC cis rs9325144 0.647 rs17518186 chr12:38883665 T/C cg26384229 chr12:38710491 ALG10B -0.56 -7.87 -0.44 9.32e-14 Morning vs. evening chronotype; CESC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg22907277 chr7:1156413 C7orf50 0.4 5.72 0.33 2.86e-8 Longevity;Endometriosis; CESC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg04511125 chr2:88470314 THNSL2 0.7 6.79 0.38 7.52e-11 Plasma clusterin levels; CESC cis rs2228479 0.850 rs62054599 chr16:89808850 C/G cg19635926 chr16:89946313 TCF25 0.66 5.04 0.3 8.52e-7 Skin colour saturation; CESC cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg10523679 chr1:76189770 ACADM -0.58 -6.0 -0.35 6.31e-9 Blood metabolite levels;Acylcarnitine levels; CESC trans rs4942242 1.000 rs9533572 chr13:44234265 A/C cg19169023 chr15:41853346 TYRO3 -0.48 -6.85 -0.39 5.04e-11 Response to tocilizumab in rheumatoid arthritis; CESC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg14893161 chr1:205819251 PM20D1 0.83 13.22 0.63 5.47e-31 Menarche (age at onset); CESC cis rs1046896 0.731 rs8067667 chr17:80785875 A/G cg02398342 chr17:80708632 TBCD;FN3K 0.47 5.57 0.32 6.24e-8 Glycated hemoglobin levels; CESC cis rs7635838 0.892 rs9310381 chr3:11458466 A/G cg00170343 chr3:11313890 ATG7 0.43 5.75 0.33 2.49e-8 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06526137 chr1:16174780 SPEN;FLJ37453 0.61 6.59 0.38 2.35e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01328119 chr1:228783545 DUSP5P -0.55 -6.53 -0.37 3.33e-10 Gut microbiome composition (summer); CESC cis rs15676 0.947 rs10988124 chr9:131569345 G/A cg00228799 chr9:131580591 ENDOG 0.42 5.12 0.3 5.98e-7 Blood metabolite levels; CESC cis rs2415984 0.570 rs28674745 chr14:46924415 G/C cg14871534 chr14:47121158 RPL10L -0.36 -5.43 -0.32 1.3e-7 Number of children ever born; CESC cis rs9457247 0.902 rs34560498 chr6:167395862 A/G cg25258033 chr6:167368657 RNASET2 0.41 6.14 0.35 3e-9 Crohn's disease; CESC cis rs2191566 0.664 rs62115477 chr19:44543027 T/G cg20607764 chr19:44506953 ZNF230 -0.43 -5.5 -0.32 8.85e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs4319547 0.741 rs4758644 chr12:122943915 A/C cg05707623 chr12:122985044 ZCCHC8 -0.47 -5.96 -0.34 8.08e-9 Body mass index; CESC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg07936489 chr17:37558343 FBXL20 -0.82 -12.22 -0.6 1.6e-27 Glomerular filtration rate (creatinine); CESC cis rs72781680 1.000 rs17712391 chr2:24245659 C/T cg08917208 chr2:24149416 ATAD2B 1.08 9.35 0.5 3.75e-18 Lymphocyte counts; CESC cis rs2832191 0.655 rs2247110 chr21:30323888 G/A cg08807101 chr21:30365312 RNF160 -0.91 -13.6 -0.64 2.52e-32 Dental caries; CESC cis rs6910061 1.000 rs5027679 chr6:11118871 A/G cg27233058 chr6:11094804 LOC221710 -0.44 -5.06 -0.3 7.84e-7 Diabetic kidney disease; CESC cis rs1577917 1.000 rs35797755 chr6:86706554 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.43 -0.37 5.9e-10 Response to antipsychotic treatment; CESC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg07507251 chr3:52567010 NT5DC2 0.4 7.03 0.4 1.75e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24578075 chr1:154193269 C1orf43;UBAP2L 0.59 6.54 0.37 3.17e-10 Gut microbiome composition (summer); CESC cis rs12479064 0.724 rs2309618 chr2:99974473 G/A cg09787394 chr2:99771194 LIPT1;TSGA10 0.48 5.06 0.3 7.78e-7 Chronic sinus infection; CESC cis rs11122272 0.766 rs1435166 chr1:231502310 T/C cg06096015 chr1:231504339 EGLN1 0.42 6.12 0.35 3.3e-9 Hemoglobin concentration; CESC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg02569458 chr12:86230093 RASSF9 0.52 7.46 0.42 1.24e-12 Major depressive disorder; CESC cis rs138229 0.506 rs9628282 chr22:50534952 G/T cg16473166 chr22:50639996 SELO 0.45 5.09 0.3 6.68e-7 Behavioural disinhibition (generation interaction); CESC trans rs1545843 0.564 rs11116374 chr12:84811788 C/G cg03015433 chr16:56623111 MT3 -0.34 -6.21 -0.36 2.09e-9 Major depressive disorder; CESC cis rs1153858 0.725 rs74572151 chr15:45647526 T/G cg21132104 chr15:45694354 SPATA5L1 0.81 10.68 0.55 2.28e-22 Homoarginine levels; CESC cis rs6912958 0.684 rs4707382 chr6:88320641 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.83 -0.39 5.9e-11 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26933736 chr6:83902998 RWDD2A;PGM3 0.54 6.0 0.35 6.59e-9 Gut microbiome composition (summer); CESC cis rs12681288 0.823 rs2701908 chr8:1003250 T/C cg15309053 chr8:964076 NA 0.35 5.91 0.34 1.05e-8 Schizophrenia; CESC trans rs561341 0.882 rs16967101 chr17:30377162 A/G cg27661571 chr11:113659931 NA -0.67 -6.78 -0.38 7.81e-11 Hip circumference adjusted for BMI; CESC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg10150615 chr22:24372951 LOC391322 -0.56 -7.93 -0.44 6.2e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12618769 0.597 rs17032870 chr2:99132786 C/T cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg23422044 chr7:1970798 MAD1L1 -0.54 -5.85 -0.34 1.42e-8 Bipolar disorder; CESC cis rs910316 1.000 rs175492 chr14:75545220 A/C cg11812906 chr14:75593930 NEK9 0.87 15.01 0.68 2.94e-37 Height; CESC cis rs12477438 0.871 rs62156364 chr2:99695097 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.64 -0.42 3.96e-13 Chronic sinus infection; CESC cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg04455712 chr21:45112962 RRP1B 0.39 5.87 0.34 1.29e-8 Mean corpuscular volume; CESC cis rs5167 0.504 rs3760629 chr19:45458146 A/C cg09555818 chr19:45449301 APOC2 0.38 6.03 0.35 5.51e-9 Blood protein levels; CESC cis rs7647973 0.626 rs9824435 chr3:49674343 A/G cg06212747 chr3:49208901 KLHDC8B -0.66 -7.3 -0.41 3.29e-12 Menarche (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24320737 chr6:170068102 WDR27 0.45 6.33 0.36 1.03e-9 Fibrinogen levels; CESC cis rs875971 0.545 rs10261710 chr7:65714189 T/A cg25405998 chr7:65216604 CCT6P1 0.5 5.31 0.31 2.28e-7 Aortic root size; CESC cis rs9309473 0.607 rs6720094 chr2:73588076 A/G cg20560298 chr2:73613845 ALMS1 -0.46 -6.48 -0.37 4.48e-10 Metabolite levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg14655249 chr9:86595816 HNRNPK;RMI1 -0.49 -6.5 -0.37 4.04e-10 Height; CESC cis rs2425143 1.000 rs6060643 chr20:34449851 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.78 -7.03 -0.4 1.78e-11 Blood protein levels; CESC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg15052019 chr19:19431593 KIAA0892;SF4 -0.42 -5.31 -0.31 2.38e-7 Tonsillectomy; CESC trans rs1814175 0.817 rs6486044 chr11:49982718 C/T cg03929089 chr4:120376271 NA -0.93 -15.75 -0.7 6.66e-40 Height; CESC cis rs2839186 0.721 rs13051200 chr21:47701693 A/T cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 6.74e-11 Testicular germ cell tumor; CESC cis rs1355223 0.552 rs2421743 chr11:34882840 C/T cg11058730 chr11:34937778 PDHX;APIP 0.84 13.04 0.63 2.37e-30 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs3812831 0.695 rs6560935 chr13:114945867 G/A cg08824895 chr13:115047677 UPF3A 0.39 5.13 0.3 5.52e-7 Schizophrenia; CESC cis rs11124063 1 rs11124063 chr2:106458806 T/C cg16077055 chr2:106428750 NCK2 0.42 6.31 0.36 1.18e-9 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05976228 chr2:74329082 TET3 -0.5 -5.99 -0.35 6.71e-9 Gut microbiome composition (summer); CESC cis rs738322 0.870 rs5750558 chr22:38582497 G/A cg25457927 chr22:38595422 NA 0.32 6.13 0.35 3.14e-9 Cutaneous nevi; CESC cis rs56104184 0.775 rs56149557 chr19:49401384 C/A cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7666738 0.519 rs28539191 chr4:98821552 C/T cg05340658 chr4:99064831 C4orf37 0.54 6.39 0.37 7.37e-10 Colonoscopy-negative controls vs population controls; CESC cis rs1697139 0.604 rs874550 chr5:66530945 C/T cg11553311 chr5:66541588 NA -0.35 -5.07 -0.3 7.45e-7 Breast cancer; CESC cis rs4595586 0.525 rs34204378 chr12:39425759 C/T cg26384229 chr12:38710491 ALG10B 0.6 8.05 0.44 2.83e-14 Morning vs. evening chronotype; CESC cis rs11098499 0.955 rs13129661 chr4:120152909 C/G cg24375607 chr4:120327624 NA 0.42 5.05 0.3 8.26e-7 Corneal astigmatism; CESC cis rs9303401 0.614 rs17175663 chr17:57108437 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.61 0.61 7.2e-29 Cognitive test performance; CESC cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09276982 chr10:15130648 ACBD7 0.55 6.27 0.36 1.49e-9 Gut microbiome composition (summer); CESC cis rs1707322 0.691 rs11211174 chr1:46220816 C/G cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs116095464 0.558 rs7713524 chr5:276200 C/T cg00938859 chr5:1591904 SDHAP3 -0.6 -6.61 -0.38 2.13e-10 Breast cancer; CESC cis rs4924935 1.000 rs6502674 chr17:18776897 A/G cg26378065 chr17:18585709 ZNF286B 0.43 5.5 0.32 8.97e-8 Pancreatic cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06985755 chr7:39663123 RALA -0.51 -6.51 -0.37 3.82e-10 Ulcerative colitis; CESC cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg16339924 chr4:17578868 LAP3 0.84 10.6 0.55 4.09e-22 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04915425 chr11:47236385 DDB2 0.48 6.38 0.36 7.67e-10 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11455386 chr1:2458039 PANK4 -0.6 -6.82 -0.39 6.18e-11 Gut microbiome composition (summer); CESC cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg03213289 chr20:61660250 NA -0.39 -5.97 -0.34 7.66e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09909877 chr22:38203717 GCAT -0.52 -6.1 -0.35 3.68e-9 Gut microbiome composition (summer); CESC cis rs3771570 1.000 rs6752050 chr2:242228780 T/C cg21155796 chr2:242212141 HDLBP 0.62 5.18 0.3 4.34e-7 Prostate cancer; CESC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg22920501 chr2:26401640 FAM59B -0.97 -12.08 -0.6 4.81e-27 Gut microbiome composition (summer); CESC cis rs7116495 0.881 rs7930142 chr11:71737016 C/T cg26138937 chr11:71823887 C11orf51 -0.77 -6.19 -0.36 2.3e-9 Severe influenza A (H1N1) infection; CESC cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg18876405 chr7:65276391 NA 0.49 6.1 0.35 3.74e-9 Aortic root size; CESC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -6.73 -0.38 1.07e-10 Bipolar disorder; CESC cis rs7927771 0.832 rs4992357 chr11:47393638 C/T cg18512352 chr11:47633146 NA -0.46 -6.65 -0.38 1.71e-10 Subjective well-being; CESC cis rs17376456 0.877 rs9885329 chr5:93380278 G/A cg25358565 chr5:93447407 FAM172A 1.14 10.54 0.54 6.24e-22 Diabetic retinopathy; CESC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg26335602 chr6:28129616 ZNF389 0.44 5.7 0.33 3.16e-8 Parkinson's disease; CESC cis rs12738007 0.544 rs4654390 chr1:29439016 T/A cg01925633 chr1:29338769 EPB41 0.35 5.03 0.3 9.09e-7 Schizophrenia; CESC cis rs7914558 0.966 rs10786721 chr10:104654383 C/A cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.45e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs36051895 0.664 rs3780377 chr9:5110899 T/C cg02405213 chr9:5042618 JAK2 -0.54 -6.33 -0.36 1.02e-9 Pediatric autoimmune diseases; CESC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg08968635 chr6:28129556 ZNF389 0.4 5.26 0.31 3e-7 Depression; CESC cis rs3820068 0.603 rs932602 chr1:15986087 A/G cg16988262 chr1:15930761 NA 0.34 5.64 0.33 4.34e-8 Systolic blood pressure; CESC trans rs79976124 0.842 rs74881738 chr6:66621825 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 8.11 0.45 1.91e-14 Type 2 diabetes; CESC cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg03467027 chr4:99064603 C4orf37 0.47 5.93 0.34 9.46e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg02951883 chr7:2050386 MAD1L1 -0.42 -5.48 -0.32 1.01e-7 Schizophrenia; CESC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg05315796 chr3:52349193 DNAH1 0.39 6.46 0.37 4.99e-10 Bipolar disorder; CESC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg12463550 chr7:65579703 CRCP 0.56 7.07 0.4 1.39e-11 Aortic root size; CESC cis rs4268898 0.931 rs2111882 chr2:24434424 A/G cg06627628 chr2:24431161 ITSN2 0.66 7.58 0.42 5.73e-13 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23469188 chr7:108166441 PNPLA8 0.6 6.56 0.37 2.76e-10 Gut microbiome composition (summer); CESC cis rs11122272 0.735 rs910822 chr1:231498721 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.27 0.36 1.47e-9 Hemoglobin concentration; CESC cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg09033563 chr22:24373618 LOC391322 0.47 5.69 0.33 3.42e-8 Urinary 1,3-butadiene metabolite levels in smokers; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08688335 chr8:144635260 GSDMD 0.49 6.34 0.36 1e-9 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09623457 chr3:183735666 ABCC5 0.6 7.45 0.42 1.32e-12 Gut microbiome composition (summer); CESC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg12288994 chr5:1860383 NA 0.41 6.88 0.39 4.39e-11 Cardiovascular disease risk factors; CESC cis rs6484504 0.532 rs7117286 chr11:31283810 T/A cg14844989 chr11:31128820 NA -0.36 -5.14 -0.3 5.47e-7 Red blood cell count; CESC trans rs17536732 0.685 rs74542350 chr4:162858977 G/A cg12177677 chr2:158300475 CYTIP -0.63 -6.2 -0.36 2.17e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs938554 0.513 rs10939650 chr4:9998440 C/T cg00071950 chr4:10020882 SLC2A9 0.66 9.08 0.49 2.51e-17 Blood metabolite levels; CESC cis rs9902453 0.904 rs11080115 chr17:28408070 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -8.81 -0.48 1.74e-16 Coffee consumption (cups per day); CESC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs34779708 0.733 rs16935945 chr10:35540320 A/C cg04310649 chr10:35416472 CREM -0.47 -5.39 -0.31 1.59e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs1878931 0.507 rs8054222 chr16:3413477 C/T cg02880119 chr16:3481970 NA 0.41 5.2 0.3 4.01e-7 Body mass index (adult); CESC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg17372223 chr3:52568218 NT5DC2 0.43 6.31 0.36 1.14e-9 Bipolar disorder; CESC cis rs12477438 0.501 rs11683107 chr2:99759235 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.89 0.62 7.96e-30 Chronic sinus infection; CESC cis rs829883 0.763 rs249843 chr12:98870987 G/A cg25150519 chr12:98850993 NA 0.86 14.72 0.67 3.04e-36 Colorectal adenoma (advanced); CESC cis rs10876993 0.855 rs1689585 chr12:58080140 A/G cg18357645 chr12:58087776 OS9 -0.64 -10.58 -0.54 4.84e-22 Celiac disease or Rheumatoid arthritis; CESC cis rs116095464 0.558 rs9688136 chr5:229348 T/C cg22857025 chr5:266934 NA -1.28 -18.8 -0.76 1.06e-50 Breast cancer; CESC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg27094323 chr7:1216898 NA -0.36 -5.05 -0.3 8.23e-7 Longevity;Endometriosis; CESC cis rs12478296 1.000 rs59036157 chr2:243040228 C/A cg06360820 chr2:242988706 NA -0.86 -8.97 -0.48 5.46e-17 Obesity-related traits; CESC cis rs9905704 0.633 rs2021733 chr17:56489168 C/T cg12560992 chr17:57184187 TRIM37 -0.62 -5.62 -0.33 4.95e-8 Testicular germ cell tumor; CESC cis rs3136441 1.000 rs57704144 chr11:46770359 C/T cg25783544 chr11:47291846 MADD 0.56 5.19 0.3 4.21e-7 HDL cholesterol; CESC cis rs6499255 0.951 rs7186002 chr16:69751065 C/G cg15192750 chr16:69999425 NA 0.5 5.87 0.34 1.32e-8 IgE levels; CESC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.59 0.32 5.72e-8 Bipolar disorder; CESC cis rs11583043 1.000 rs2391573 chr1:101489698 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.63 0.33 4.65e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs7666738 0.830 rs7664051 chr4:98766970 C/G cg05340658 chr4:99064831 C4orf37 0.76 11.12 0.56 7.66e-24 Colonoscopy-negative controls vs population controls; CESC cis rs921968 0.509 rs72963905 chr2:219547027 T/G cg02176678 chr2:219576539 TTLL4 -0.57 -9.75 -0.51 2.11e-19 Mean corpuscular hemoglobin concentration; CESC cis rs2576037 0.901 rs2576036 chr18:44587102 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.45 -5.7 -0.33 3.23e-8 Personality dimensions; CESC cis rs8067545 1.000 rs4925067 chr17:19921222 C/G cg13482628 chr17:19912719 NA 0.46 6.2 0.36 2.19e-9 Schizophrenia; CESC cis rs875971 0.662 rs448725 chr7:65514628 A/G cg11764359 chr7:65958608 NA 0.88 13.01 0.62 3.05e-30 Aortic root size; CESC cis rs10751667 0.714 rs7395879 chr11:963855 G/C cg01483505 chr11:975446 AP2A2 0.36 5.05 0.3 8.13e-7 Alzheimer's disease (late onset); CESC cis rs11098499 0.863 rs11933966 chr4:120476715 G/A cg24375607 chr4:120327624 NA 0.45 5.54 0.32 7.33e-8 Corneal astigmatism; CESC cis rs863345 0.604 rs12063320 chr1:158499423 A/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs748404 0.631 rs28702649 chr15:43648629 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.86 0.43 9.51e-14 Lung cancer; CESC cis rs9649465 1.000 rs11770041 chr7:123365788 C/T cg04330084 chr7:123175371 IQUB -0.39 -5.23 -0.31 3.47e-7 Migraine; CESC cis rs4409675 0.576 rs6679432 chr1:28227665 T/C cg23691781 chr1:28212827 C1orf38 0.29 5.75 0.33 2.49e-8 Corneal astigmatism; CESC cis rs9911578 0.805 rs12601867 chr17:56455260 C/G cg25039879 chr17:56429692 SUPT4H1 -0.42 -5.74 -0.33 2.52e-8 Intelligence (multi-trait analysis); CESC cis rs6690583 1.000 rs6690583 chr1:85466337 A/G cg11262906 chr1:85462892 MCOLN2 -0.57 -6.65 -0.38 1.71e-10 Serum sulfate level; CESC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Depression; CESC cis rs71636778 0.543 rs10493037 chr1:27248645 A/G cg12203394 chr1:27248618 NUDC 0.66 5.55 0.32 6.85e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs12042052 1.000 rs6696779 chr1:232920825 G/A cg06935979 chr1:232941706 KIAA1383 0.62 5.48 0.32 9.65e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs9611565 0.559 rs7290990 chr22:41964357 C/A cg06481639 chr22:41940642 POLR3H -0.57 -6.38 -0.36 7.88e-10 Vitiligo; CESC cis rs4664308 0.935 rs4520994 chr2:160937750 G/A cg03641300 chr2:160917029 PLA2R1 -0.67 -9.84 -0.52 1.11e-19 Idiopathic membranous nephropathy; CESC cis rs11098499 0.731 rs9995026 chr4:120490499 T/A cg24375607 chr4:120327624 NA 0.46 5.59 0.32 5.73e-8 Corneal astigmatism; CESC cis rs6541297 0.702 rs4846904 chr1:230279410 G/A cg20703242 chr1:230279135 GALNT2 0.68 10.78 0.55 1.05e-22 Coronary artery disease; CESC cis rs7551222 0.752 rs10793765 chr1:204549375 A/G cg20240347 chr1:204465584 NA -0.29 -5.88 -0.34 1.2e-8 Schizophrenia; CESC cis rs67311347 0.506 rs55962832 chr3:40244451 T/C cg09455208 chr3:40491958 NA 0.35 5.49 0.32 9.28e-8 Renal cell carcinoma; CESC cis rs539096 0.500 rs2906457 chr1:44338575 A/C cg13606994 chr1:44402422 ARTN -0.38 -6.05 -0.35 4.82e-9 Intelligence (multi-trait analysis); CESC cis rs36051895 0.659 rs12343867 chr9:5074189 T/C cg02405213 chr9:5042618 JAK2 -0.53 -6.44 -0.37 5.75e-10 Pediatric autoimmune diseases; CESC cis rs4253772 0.678 rs9627281 chr22:46644168 A/G cg24881330 chr22:46731750 TRMU 0.73 8.07 0.44 2.51e-14 LDL cholesterol;Cholesterol, total; CESC cis rs4906332 1.000 rs8012623 chr14:103937086 G/A cg09975044 chr14:104007538 NA 0.47 6.48 0.37 4.51e-10 Coronary artery disease; CESC cis rs9815354 0.767 rs61283393 chr3:41854135 T/G cg03022575 chr3:42003672 ULK4 0.7 6.34 0.36 1.01e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg00031303 chr3:195681400 NA 0.46 5.78 0.33 2.13e-8 Pancreatic cancer; CESC cis rs2439831 0.867 rs2899082 chr15:43656043 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.11 0.63 1.34e-30 Lung cancer in ever smokers; CESC cis rs3126085 0.935 rs1496045 chr1:152184704 C/T cg03465714 chr1:152285911 FLG -0.43 -5.16 -0.3 4.81e-7 Atopic dermatitis; CESC cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg26597838 chr10:835615 NA 1.18 11.47 0.58 5.21e-25 Eosinophil percentage of granulocytes; CESC cis rs5758659 0.652 rs133314 chr22:42401841 G/A cg04733989 chr22:42467013 NAGA 0.43 5.72 0.33 2.8e-8 Cognitive function; CESC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04774194 chr6:127664674 ECHDC1 -0.51 -6.57 -0.37 2.71e-10 Ulcerative colitis; CESC cis rs2963155 0.518 rs56150733 chr5:142765099 T/C cg17617527 chr5:142782415 NR3C1 0.82 6.79 0.39 7.2e-11 Breast cancer; CESC cis rs34779708 0.931 rs11597392 chr10:35288575 T/C cg04310649 chr10:35416472 CREM -0.48 -5.67 -0.33 3.81e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg02931644 chr1:25747376 RHCE 0.44 7.48 0.42 1.08e-12 Erythrocyte sedimentation rate; CESC cis rs2439831 0.850 rs28413704 chr15:44148427 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.6 0.33 5.26e-8 Lung cancer in ever smokers; CESC cis rs2197308 0.765 rs11182964 chr12:37935052 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.81 0.39 6.71e-11 Morning vs. evening chronotype; CESC cis rs3747547 0.685 rs72726082 chr9:38119334 A/G cg13774184 chr9:37916125 SHB -0.6 -5.03 -0.3 9.11e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs11563648 0.553 rs6957320 chr7:126998210 C/T cg25922125 chr7:127225783 GCC1 -0.42 -5.11 -0.3 6.29e-7 Resting heart rate; CESC cis rs7771547 0.573 rs522179 chr6:36391605 G/A cg04289385 chr6:36355825 ETV7 0.39 5.65 0.33 4.2e-8 Platelet distribution width; CESC cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg11279151 chr3:101281821 RG9MTD1 -0.45 -5.07 -0.3 7.59e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg18240062 chr17:79603768 NPLOC4 0.72 10.27 0.53 4.71e-21 Eye color traits; CESC cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs523522 0.962 rs4766969 chr12:120988238 A/G cg12219531 chr12:120966889 COQ5 0.74 9.75 0.51 2.17e-19 High light scatter reticulocyte count; CESC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg16743903 chr16:89593216 SPG7 -0.46 -6.0 -0.35 6.51e-9 Multiple myeloma (IgH translocation); CESC cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg05347473 chr6:146136440 FBXO30 -0.58 -7.36 -0.41 2.32e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg12667521 chr19:29218732 NA 0.48 6.4 0.37 6.97e-10 Methadone dose in opioid dependence; CESC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg02951883 chr7:2050386 MAD1L1 -0.51 -6.8 -0.39 6.8e-11 Bipolar disorder and schizophrenia; CESC cis rs2243480 1.000 rs316332 chr7:65604299 A/G cg13147721 chr7:65941812 NA -0.94 -8.91 -0.48 8.25e-17 Diabetic kidney disease; CESC cis rs10129255 0.957 rs10141052 chr14:107184767 G/A cg23076370 chr14:107095027 NA -0.48 -6.29 -0.36 1.32e-9 Kawasaki disease; CESC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg02569458 chr12:86230093 RASSF9 0.57 8.38 0.46 3.07e-15 Major depressive disorder; CESC cis rs9457247 0.740 rs10946204 chr6:167451129 T/C cg23791538 chr6:167370224 RNASET2 -0.55 -7.66 -0.43 3.42e-13 Crohn's disease; CESC cis rs9303401 0.614 rs34941454 chr17:57102742 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.87 10.87 0.56 5.18e-23 Cognitive test performance; CESC cis rs9649213 1.000 rs9649213 chr7:98021211 A/G cg21770322 chr7:97807741 LMTK2 -0.41 -5.78 -0.33 2.1e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg26338869 chr17:61819248 STRADA -0.79 -10.55 -0.54 6.11e-22 Prudent dietary pattern; CESC cis rs2243480 1.000 rs316312 chr7:65596491 T/G cg18252515 chr7:66147081 NA -1.41 -14.36 -0.66 5.44e-35 Diabetic kidney disease; CESC cis rs6831352 0.734 rs3100630 chr4:100031715 T/A cg13256891 chr4:100009986 ADH5 0.69 8.13 0.45 1.61e-14 Alcohol dependence; CESC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg00484396 chr16:3507460 NAT15 0.43 6.91 0.39 3.52e-11 Tuberculosis; CESC cis rs6584283 0.766 rs7911680 chr10:101293468 A/C cg09788492 chr10:101292477 NKX2-3 0.33 5.96 0.34 8.16e-9 Ulcerative colitis; CESC cis rs561341 0.941 rs2428338 chr17:30299629 T/C cg19193384 chr17:30244184 NA -0.6 -6.24 -0.36 1.72e-9 Hip circumference adjusted for BMI; CESC cis rs7312933 0.585 rs7969814 chr12:42669657 C/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.45 5.88 0.34 1.2e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg16339924 chr4:17578868 LAP3 0.57 7.13 0.4 9.77e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs35110281 0.840 rs7276633 chr21:45078800 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 6.89 0.39 4.06e-11 Mean corpuscular volume; CESC cis rs12579753 1.000 rs17749267 chr12:82178308 A/G cg21193143 chr12:82153300 PPFIA2 0.35 5.06 0.3 7.88e-7 Resting heart rate; CESC cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.43 0.61 3.04e-28 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg07677032 chr17:61819896 STRADA 0.49 6.67 0.38 1.46e-10 Prudent dietary pattern; CESC trans rs4596713 0.538 rs7865373 chr9:71765105 T/C cg16512924 chr15:28394682 HERC2 0.51 6.61 0.38 2.05e-10 Headache; CESC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg09177884 chr7:1199841 ZFAND2A -0.42 -5.29 -0.31 2.6e-7 Longevity;Endometriosis; CESC cis rs9905704 0.525 rs2632515 chr17:56444883 A/G cg12560992 chr17:57184187 TRIM37 0.63 5.5 0.32 8.81e-8 Testicular germ cell tumor; CESC cis rs1030268 0.505 rs80305547 chr7:133259400 A/G cg10665199 chr7:133106180 EXOC4 0.52 5.45 0.32 1.14e-7 Intelligence (multi-trait analysis); CESC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg09467607 chr2:36825704 FEZ2 0.61 11.73 0.58 7.01e-26 Height; CESC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg26769984 chr7:1090371 C7orf50 -0.56 -6.49 -0.37 4.23e-10 Bronchopulmonary dysplasia; CESC trans rs9858542 0.953 rs9862080 chr3:49674458 A/G cg21659725 chr3:3221576 CRBN -0.52 -6.3 -0.36 1.21e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs11122272 0.701 rs11582413 chr1:231530098 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs1707322 0.827 rs6683274 chr1:46241638 T/G cg06784218 chr1:46089804 CCDC17 0.38 6.29 0.36 1.33e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs977987 0.806 rs12933281 chr16:75483064 T/G cg03315344 chr16:75512273 CHST6 0.46 6.5 0.37 4.03e-10 Dupuytren's disease; CESC cis rs4964805 0.683 rs12424737 chr12:104196221 A/C cg02344784 chr12:104178138 NT5DC3 0.45 6.29 0.36 1.32e-9 Attention deficit hyperactivity disorder; CESC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg05368731 chr17:41323189 NBR1 0.78 10.13 0.53 1.33e-20 Menopause (age at onset); CESC cis rs3733585 0.699 rs10001964 chr4:9959275 C/T cg11266682 chr4:10021025 SLC2A9 -0.6 -11.15 -0.57 6.33e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15197458 chr19:3464765 NA 0.45 6.22 0.36 1.97e-9 Fibrinogen levels; CESC cis rs910316 1.000 rs10142865 chr14:75555624 G/A cg11812906 chr14:75593930 NEK9 0.91 15.88 0.7 2.25e-40 Height; CESC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg14926445 chr8:58193284 C8orf71 -0.49 -5.29 -0.31 2.57e-7 Developmental language disorder (linguistic errors); CESC cis rs11958404 0.932 rs72816563 chr5:157427447 C/T cg05962755 chr5:157440814 NA 0.62 6.61 0.38 2.14e-10 IgG glycosylation; CESC cis rs116095464 0.558 rs9688045 chr5:254035 T/C cg22857025 chr5:266934 NA -1.29 -18.21 -0.75 1.29e-48 Breast cancer; CESC cis rs3820068 0.677 rs72643691 chr1:15856251 T/C cg18192808 chr1:15853278 DNAJC16 0.47 5.81 0.34 1.75e-8 Systolic blood pressure; CESC cis rs7647973 1.000 rs3905330 chr3:49550774 A/G cg06212747 chr3:49208901 KLHDC8B 0.59 8.03 0.44 3.22e-14 Menarche (age at onset); CESC cis rs11048434 0.673 rs11611106 chr12:9060204 A/C cg23795048 chr12:9217529 LOC144571 -0.35 -5.5 -0.32 8.92e-8 Sjögren's syndrome; CESC cis rs76419734 0.510 rs2544417 chr4:106745405 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.63 -6.37 -0.36 8.24e-10 Post bronchodilator FEV1; CESC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg21784768 chr11:537496 LRRC56 -0.54 -5.11 -0.3 6.29e-7 Body mass index; CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg12419862 chr22:24373484 LOC391322 0.9 13.82 0.65 4.45e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1387259 0.758 rs2634670 chr12:48771877 G/A cg04545296 chr12:48745243 ZNF641 0.36 6.01 0.35 6.28e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs61332075 0.518 rs112649209 chr2:239422814 C/G cg18131467 chr2:239335373 ASB1 -0.72 -5.81 -0.34 1.76e-8 Lung function (FEV1/FVC); CESC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg26335602 chr6:28129616 ZNF389 0.44 5.61 0.33 5.19e-8 Parkinson's disease; CESC cis rs60843830 0.596 rs17041320 chr2:112051 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.48 5.74 0.33 2.6e-8 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs796364 1.000 rs796364 chr2:200716119 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.87 8.56 0.47 9.55e-16 Schizophrenia; CESC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg23048001 chr7:2026167 MAD1L1 0.5 6.35 0.36 9.34e-10 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.606 rs10006454 chr4:99080361 G/A cg17366294 chr4:99064904 C4orf37 0.43 5.71 0.33 3.05e-8 Colonoscopy-negative controls vs population controls; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25722142 chr6:139695762 CITED2 0.49 6.6 0.38 2.27e-10 Systemic lupus erythematosus; CESC cis rs2991971 0.729 rs10890328 chr1:45905383 G/T cg15605315 chr1:45957053 TESK2 -0.39 -5.39 -0.31 1.56e-7 High light scatter reticulocyte count; CESC cis rs9300255 0.620 rs1716173 chr12:123660721 A/T cg05973401 chr12:123451056 ABCB9 0.49 5.49 0.32 9.51e-8 Neutrophil percentage of white cells; CESC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg17372223 chr3:52568218 NT5DC2 0.39 6.1 0.35 3.84e-9 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00647403 chr16:23521932 GGA2 -0.66 -7.95 -0.44 5.29e-14 Gut microbiome composition (summer); CESC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg06028808 chr11:68637592 NA 0.43 5.12 0.3 5.87e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6088580 0.634 rs3746455 chr20:32957216 G/A cg06115741 chr20:33292138 TP53INP2 -0.44 -5.62 -0.33 4.71e-8 Glomerular filtration rate (creatinine); CESC cis rs6991838 0.584 rs2175810 chr8:66555818 A/C cg13398993 chr8:66546079 ARMC1 -0.47 -5.65 -0.33 4.12e-8 Intelligence (multi-trait analysis); CESC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.47 -0.32 1.05e-7 Total body bone mineral density; CESC cis rs6964587 0.626 rs1011372 chr7:91509867 T/C cg17063962 chr7:91808500 NA -0.45 -6.35 -0.36 9.06e-10 Breast cancer; CESC cis rs7843479 0.965 rs13269198 chr8:21823025 G/A cg17168535 chr8:21777572 XPO7 0.5 6.82 0.39 6.27e-11 Mean corpuscular volume; CESC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.79 0.48 1.9e-16 Bipolar disorder; CESC cis rs6088580 0.634 rs11700221 chr20:32940320 T/C cg08999081 chr20:33150536 PIGU -0.64 -11.05 -0.56 1.4e-23 Glomerular filtration rate (creatinine); CESC cis rs3857067 0.967 rs1509942 chr4:95013440 G/T cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs7647973 0.587 rs10452032 chr3:49680973 G/A cg06212747 chr3:49208901 KLHDC8B 0.64 7.75 0.43 1.94e-13 Menarche (age at onset); CESC cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4835473 0.864 rs28423022 chr4:144887569 A/G cg25736465 chr4:144833511 NA 0.41 6.37 0.36 8.26e-10 Immature fraction of reticulocytes; CESC cis rs896854 0.517 rs2013597 chr8:95951807 G/A cg09323728 chr8:95962352 TP53INP1 -0.35 -6.53 -0.37 3.29e-10 Type 2 diabetes; CESC cis rs847577 0.609 rs6465658 chr7:97816638 C/G cg24562669 chr7:97807699 LMTK2 0.81 12.94 0.62 5.24e-30 Breast cancer; CESC cis rs11690935 0.549 rs796839 chr2:172916214 A/C cg13550731 chr2:172543902 DYNC1I2 0.5 6.77 0.38 8.32e-11 Schizophrenia; CESC cis rs9303401 0.614 rs34550282 chr17:57092788 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.87 10.87 0.56 5.18e-23 Cognitive test performance; CESC cis rs888194 0.966 rs6606725 chr12:109905368 C/A cg19025524 chr12:109796872 NA -0.34 -5.04 -0.3 8.68e-7 Neuroticism; CESC trans rs9858542 0.953 rs7633271 chr3:49555963 T/C cg21659725 chr3:3221576 CRBN -0.54 -6.71 -0.38 1.19e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7824557 0.606 rs1047950 chr8:11185096 G/C cg21775007 chr8:11205619 TDH 0.5 7.24 0.41 4.76e-12 Retinal vascular caliber; CESC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg08499158 chr17:42289980 UBTF -0.53 -6.89 -0.39 3.94e-11 Total body bone mineral density; CESC cis rs55788414 0.932 rs2317119 chr16:81182854 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.97 -0.39 2.49e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.77 0.8 6.03e-61 Prudent dietary pattern; CESC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.39 0.31 1.52e-7 Tonsillectomy; CESC cis rs1348850 0.632 rs12471621 chr2:178502353 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.78 0.43 1.62e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg23161317 chr6:28129485 ZNF389 0.51 6.63 0.38 1.85e-10 Parkinson's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21395782 chr19:19626814 NDUFA13;TSSK6 -0.42 -6.29 -0.36 1.3e-9 Gambling; CESC cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg03213289 chr20:61660250 NA 0.39 6.16 0.35 2.7e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2274273 0.837 rs7142857 chr14:55704128 C/T cg04306507 chr14:55594613 LGALS3 0.29 5.82 0.34 1.66e-8 Protein biomarker; CESC cis rs61784830 0.710 rs61783196 chr1:46291790 C/T cg06784218 chr1:46089804 CCDC17 0.48 5.42 0.32 1.37e-7 Iron status biomarkers (total iron binding capacity); CESC cis rs7772486 0.790 rs3923579 chr6:146230232 C/G cg05347473 chr6:146136440 FBXO30 -0.57 -7.31 -0.41 3.07e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2832191 0.636 rs8131295 chr21:30516819 A/T cg24692254 chr21:30365293 RNF160 -0.63 -7.81 -0.43 1.34e-13 Dental caries; CESC cis rs1550582 0.662 rs6981748 chr8:135501309 A/C cg17885191 chr8:135476712 NA -0.84 -10.91 -0.56 3.91e-23 Educational attainment; CESC cis rs7224314 1.000 rs8070284 chr17:65387400 A/G cg01507342 chr17:65387096 PITPNC1 -0.48 -5.67 -0.33 3.82e-8 Diisocyanate-induced asthma; CESC cis rs1153858 1.000 rs11070456 chr15:45686835 G/A cg14582100 chr15:45693742 SPATA5L1 0.41 5.77 0.33 2.17e-8 Homoarginine levels; CESC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg26818010 chr10:134567672 INPP5A -0.92 -11.19 -0.57 4.64e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs826838 1.000 rs1719848 chr12:39085586 A/G cg13010199 chr12:38710504 ALG10B -0.41 -5.63 -0.33 4.66e-8 Heart rate; CESC cis rs10883723 0.847 rs3808934 chr10:104264280 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs6964587 0.585 rs10266481 chr7:91554338 T/C cg17063962 chr7:91808500 NA -0.44 -6.22 -0.36 1.9e-9 Breast cancer; CESC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg10691866 chr7:65817282 TPST1 0.33 5.21 0.3 3.74e-7 Aortic root size; CESC cis rs1364705 1.000 rs6986732 chr8:120225428 A/C cg09273054 chr8:120220131 MAL2 0.52 5.98 0.34 7.35e-9 Hippocampal atrophy; CESC cis rs7551222 0.752 rs4252694 chr1:204499056 A/G cg20240347 chr1:204465584 NA -0.28 -5.7 -0.33 3.12e-8 Schizophrenia; CESC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg09699651 chr6:150184138 LRP11 0.39 5.04 0.3 8.83e-7 Lung cancer; CESC cis rs4268898 0.722 rs11691212 chr2:24404733 A/G cg06627628 chr2:24431161 ITSN2 0.54 7.28 0.41 3.72e-12 Asthma; CESC cis rs17209837 0.646 rs10452935 chr7:87094247 A/T cg00919237 chr7:87102261 ABCB4 -0.51 -6.58 -0.37 2.45e-10 Gallbladder cancer; CESC cis rs17401966 1.000 rs11121533 chr1:10292888 G/C cg15208524 chr1:10270712 KIF1B 0.47 6.14 0.35 3.07e-9 Hepatocellular carcinoma; CESC cis rs2228479 0.850 rs45524643 chr16:89815824 G/A cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs2880765 0.835 rs7180213 chr15:86021187 G/A cg10818794 chr15:86012489 AKAP13 -0.34 -5.22 -0.31 3.66e-7 Coronary artery disease; CESC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg17949981 chr6:28129498 ZNF389 0.45 5.49 0.32 9.35e-8 Depression; CESC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg16680214 chr1:154839983 KCNN3 -0.51 -7.94 -0.44 5.69e-14 Prostate cancer; CESC cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg10523679 chr1:76189770 ACADM 0.73 8.51 0.46 1.33e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs193541 0.632 rs1903260 chr5:122135188 T/C cg19412675 chr5:122181750 SNX24 0.44 5.07 0.3 7.63e-7 Glucose homeostasis traits; CESC cis rs7147624 1.000 rs8021889 chr14:66214811 A/G cg03016385 chr14:66212404 NA -0.5 -5.25 -0.31 3.1e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.13 0.53 1.35e-20 Prudent dietary pattern; CESC trans rs1814175 0.645 rs28549248 chr11:50042740 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.71 -0.75 2.23e-50 Height; CESC cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg00745463 chr17:30367425 LRRC37B -0.85 -7.72 -0.43 2.36e-13 Hip circumference adjusted for BMI; CESC cis rs2180341 0.538 rs3756993 chr6:127651551 A/C cg24812749 chr6:127587940 RNF146 0.6 8.0 0.44 3.96e-14 Breast cancer; CESC cis rs7824557 0.525 rs12682349 chr8:11245303 C/G cg21775007 chr8:11205619 TDH 0.57 8.74 0.47 2.72e-16 Retinal vascular caliber; CESC trans rs3942852 0.524 rs7118665 chr11:48078427 C/A cg03929089 chr4:120376271 NA 0.68 8.11 0.45 1.93e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.791 rs11735105 chr4:98937357 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs826838 0.967 rs11183514 chr12:38760744 A/T cg26384229 chr12:38710491 ALG10B 0.84 14.74 0.67 2.59e-36 Heart rate; CESC cis rs7959663 1 rs7959663 chr12:109884367 G/C cg05360138 chr12:110035743 NA 0.51 5.24 0.31 3.27e-7 Bipolar disorder lithium response (categorical) or schizophrenia; CESC cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.65 9.21 0.49 1.05e-17 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.1 0.4 1.14e-11 Tonsillectomy; CESC cis rs1707322 0.721 rs10789468 chr1:46124558 A/G cg05343316 chr1:45956843 TESK2 0.48 6.05 0.35 4.85e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2996428 0.561 rs72640913 chr1:3747023 C/G cg13057898 chr1:3703894 LRRC47 0.35 5.1 0.3 6.53e-7 Red cell distribution width; CESC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg10691866 chr7:65817282 TPST1 -0.33 -5.43 -0.32 1.3e-7 Aortic root size; CESC cis rs9393777 0.623 rs9348719 chr6:26470032 T/C cg12826209 chr6:26865740 GUSBL1 0.68 7.39 0.41 1.94e-12 Intelligence (multi-trait analysis); CESC cis rs71403859 0.502 rs71403849 chr16:71484365 T/C cg08717414 chr16:71523259 ZNF19 -0.88 -8.98 -0.48 4.99e-17 Post bronchodilator FEV1; CESC cis rs1568889 1.000 rs7931847 chr11:28175245 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 9.47 0.5 1.58e-18 Bipolar disorder; CESC cis rs6088580 0.634 rs1205336 chr20:32926336 G/A cg08999081 chr20:33150536 PIGU -0.64 -11.01 -0.56 1.78e-23 Glomerular filtration rate (creatinine); CESC trans rs8073060 0.586 rs225264 chr17:33961335 A/G cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs6502050 0.769 rs4789741 chr17:80119184 A/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs12142240 0.698 rs12385695 chr1:46819021 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs7605827 0.930 rs6735633 chr2:15706096 G/A cg19274914 chr2:15703543 NA 0.37 6.6 0.38 2.23e-10 Educational attainment (years of education); CESC cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2841277 0.741 rs9672139 chr14:105408182 T/G cg17340268 chr14:105411764 AHNAK2 -0.48 -6.39 -0.37 7.62e-10 Rheumatoid arthritis; CESC cis rs1062177 0.951 rs2915876 chr5:151150745 C/A cg00977110 chr5:151150581 G3BP1 0.68 7.19 0.4 6.48e-12 Preschool internalizing problems; CESC cis rs7296418 0.961 rs1790106 chr12:123591596 G/T cg00376283 chr12:123451042 ABCB9 0.74 10.81 0.55 8.47e-23 Platelet count; CESC cis rs11958404 0.860 rs72816577 chr5:157431806 A/G cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.8 0.48 1.86e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs644799 0.542 rs10831417 chr11:95467262 A/G cg03916912 chr11:95522834 CEP57;FAM76B -0.63 -8.89 -0.48 9.51e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1949733 0.816 rs2631746 chr4:8490934 C/T cg11789530 chr4:8429930 ACOX3 -0.64 -8.58 -0.47 8.38e-16 Response to antineoplastic agents; CESC cis rs3768617 0.510 rs7529465 chr1:183096880 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs12142240 0.698 rs56358525 chr1:46849520 C/T cg00530320 chr1:46809349 NSUN4 0.6 8.3 0.45 5.19e-15 Menopause (age at onset); CESC cis rs9488822 0.676 rs13210143 chr6:116389636 G/A cg26893134 chr6:116381904 FRK 0.25 6.29 0.36 1.28e-9 Cholesterol, total;LDL cholesterol; CESC cis rs7312774 0.609 rs2374655 chr12:107380162 T/C cg16260113 chr12:107380972 MTERFD3 1.14 8.79 0.48 1.88e-16 Severe influenza A (H1N1) infection; CESC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg23161317 chr6:28129485 ZNF389 0.38 5.35 0.31 1.92e-7 Parkinson's disease; CESC cis rs11190604 1.000 rs7085439 chr10:102210100 C/T cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg19592336 chr6:28129416 ZNF389 0.62 8.14 0.45 1.55e-14 Depression; CESC cis rs1018836 0.828 rs7006279 chr8:91605364 A/G cg16814680 chr8:91681699 NA -0.71 -10.58 -0.54 4.89e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs11166629 1.000 rs3739423 chr8:135614705 A/G cg27224718 chr8:135614730 ZFAT 0.49 6.16 0.35 2.74e-9 Smoking quantity; CESC trans rs7980799 0.935 rs10772076 chr12:33553574 A/C cg26384229 chr12:38710491 ALG10B -0.52 -7.11 -0.4 1.06e-11 Heart rate;Heart rate variability traits (RMSSD); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22066304 chr19:55691730 SYT5 -0.66 -7.58 -0.42 5.75e-13 Gut microbiome composition (summer); CESC cis rs9621305 0.702 rs5749306 chr22:31976999 T/G cg25791279 chr22:32026902 PISD 0.59 5.94 0.34 8.73e-9 Intelligence; CESC cis rs2066819 1.000 rs808919 chr12:56647911 C/G cg26714650 chr12:56694279 CS 1.22 14.95 0.68 4.62e-37 Psoriasis vulgaris; CESC cis rs2243480 1.000 rs34192067 chr7:65887657 C/A cg18252515 chr7:66147081 NA -1.39 -14.18 -0.66 2.5e-34 Diabetic kidney disease; CESC trans rs11098499 0.820 rs6829903 chr4:120506884 C/T cg25214090 chr10:38739885 LOC399744 0.66 8.87 0.48 1.1e-16 Corneal astigmatism; CESC cis rs829883 0.616 rs249832 chr12:98832387 C/T cg25150519 chr12:98850993 NA 0.87 14.77 0.67 1.95e-36 Colorectal adenoma (advanced); CESC cis rs6500602 0.647 rs4786514 chr16:4576798 A/C cg08645402 chr16:4508243 NA 0.4 6.1 0.35 3.65e-9 Schizophrenia; CESC cis rs4253772 0.591 rs6008365 chr22:46652929 G/A cg24881330 chr22:46731750 TRMU 0.89 10.13 0.53 1.3e-20 LDL cholesterol;Cholesterol, total; CESC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg04944784 chr2:26401820 FAM59B -0.96 -10.55 -0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs1003719 0.715 rs2835667 chr21:38579914 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.22 -0.45 9.27e-15 Eye color traits; CESC cis rs4555082 1.000 rs7146012 chr14:105757566 G/A cg06808227 chr14:105710500 BRF1 -0.53 -6.49 -0.37 4.15e-10 Mean platelet volume;Platelet distribution width; CESC cis rs8078723 0.866 rs3935280 chr17:38189055 A/G cg17467752 chr17:38218738 THRA -0.68 -10.92 -0.56 3.76e-23 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg08564027 chr20:61660810 NA 0.9 15.29 0.68 2.9e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs10911232 0.507 rs10797817 chr1:182999136 G/T ch.1.3577855R chr1:183094577 LAMC1 0.85 13.17 0.63 8.54e-31 Hypertriglyceridemia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21348586 chr8:141461100 TRAPPC9 0.55 8.02 0.44 3.45e-14 Fibrinogen levels; CESC cis rs6674176 0.628 rs2301993 chr1:44426025 G/A cg13606994 chr1:44402422 ARTN -0.37 -5.58 -0.32 6.03e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1153858 0.723 rs1719238 chr15:45594766 C/T cg14582100 chr15:45693742 SPATA5L1 -0.38 -5.28 -0.31 2.76e-7 Homoarginine levels; CESC cis rs17854409 0.803 rs1063247 chr20:61472118 C/G cg07645718 chr20:61493192 TCFL5 0.79 5.2 0.3 3.98e-7 Obesity-related traits; CESC cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg12163867 chr12:51592794 POU6F1 -0.5 -6.68 -0.38 1.43e-10 Cisplatin-induced ototoxicity; CESC cis rs1983891 1.000 rs4714485 chr6:41536587 T/G cg20194872 chr6:41519635 FOXP4 0.55 7.83 0.43 1.17e-13 Prostate cancer; CESC cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg17724175 chr1:150552817 MCL1 0.44 7.25 0.41 4.48e-12 Tonsillectomy; CESC cis rs8028182 0.609 rs8038760 chr15:75742095 A/C cg20655648 chr15:75932815 IMP3 0.49 6.09 0.35 3.97e-9 Sudden cardiac arrest; CESC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg16325326 chr1:53192061 ZYG11B 0.91 15.48 0.69 6.08e-39 Monocyte count; CESC cis rs13064411 0.696 rs7631082 chr3:113208913 C/G cg18753928 chr3:113234510 CCDC52 -0.52 -6.31 -0.36 1.17e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs1728785 1.000 rs7205960 chr16:68565604 G/C cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs11155671 0.530 rs9371542 chr6:150213085 A/T cg09699651 chr6:150184138 LRP11 0.54 7.46 0.42 1.22e-12 Testicular germ cell tumor; CESC cis rs4237845 0.816 rs61935769 chr12:58294344 G/A cg00677455 chr12:58241039 CTDSP2 0.64 7.73 0.43 2.31e-13 Intelligence (multi-trait analysis); CESC cis rs7178909 0.902 rs2043882 chr15:90439753 G/A cg19708238 chr15:90437601 AP3S2 0.44 6.28 0.36 1.38e-9 Common traits (Other); CESC cis rs7216064 1.000 rs2365468 chr17:65841318 C/T cg07042672 chr17:66097459 LOC651250 -0.63 -7.54 -0.42 7.64e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs8057939 1.000 rs8060115 chr16:49391968 A/G cg16782675 chr3:63943755 ATXN7 -0.57 -6.04 -0.35 5.21e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs28489187 0.666 rs233132 chr1:85796545 A/G cg16011679 chr1:85725395 C1orf52 0.47 5.6 0.33 5.46e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.83 0.34 1.64e-8 Bipolar disorder; CESC cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg06212747 chr3:49208901 KLHDC8B 0.64 8.55 0.46 9.98e-16 Parkinson's disease; CESC cis rs34330 0.562 rs11055025 chr12:12866619 A/T cg04607235 chr12:12878440 APOLD1 -0.76 -8.36 -0.46 3.53e-15 Systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18891615 chr8:101962925 YWHAZ -0.47 -6.13 -0.35 3.14e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13898697 chr1:36641773 MAP7D1 -0.58 -6.42 -0.37 6.09e-10 Gut microbiome composition (summer); CESC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg18225595 chr11:63971243 STIP1 0.64 9.01 0.48 4.06e-17 Platelet count; CESC cis rs9916302 0.706 rs584377 chr17:37460128 G/A cg07936489 chr17:37558343 FBXL20 0.87 9.4 0.5 2.59e-18 Glomerular filtration rate (creatinine); CESC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg14159672 chr1:205819179 PM20D1 0.8 12.23 0.6 1.45e-27 Menarche (age at onset); CESC cis rs6696846 0.740 rs17344537 chr1:205091427 T/G cg00857998 chr1:205179979 DSTYK 0.56 7.33 0.41 2.86e-12 Red blood cell count; CESC cis rs7429990 0.965 rs6770467 chr3:48019232 A/G cg11946769 chr3:48343235 NME6 -0.44 -5.38 -0.31 1.65e-7 Educational attainment (years of education); CESC cis rs3858526 0.752 rs11040173 chr11:6009378 A/G cg05234568 chr11:5960015 NA 0.45 5.16 0.3 4.76e-7 DNA methylation (variation); CESC cis rs2637266 0.935 rs7900900 chr10:78367383 A/T cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC cis rs11122272 0.668 rs2749712 chr1:231537751 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.47 -0.42 1.15e-12 Hemoglobin concentration; CESC cis rs62034325 0.697 rs710410 chr16:28603342 A/G cg07382826 chr16:28625726 SULT1A1 0.4 6.49 0.37 4.11e-10 Body mass index; CESC cis rs950776 0.518 rs3813571 chr15:78832792 G/T cg06917634 chr15:78832804 PSMA4 0.81 12.58 0.61 8.9e-29 Sudden cardiac arrest; CESC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg06028808 chr11:68637592 NA 0.43 5.12 0.3 5.87e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1843834 0.539 rs10177898 chr2:225437552 C/T cg12698349 chr2:225449008 CUL3 0.61 8.74 0.47 2.73e-16 IgE levels in asthmatics (D.p. specific); CESC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg02353165 chr6:42928485 GNMT 0.83 13.12 0.63 1.26e-30 Alzheimer's disease in APOE e4+ carriers; CESC cis rs72627123 0.656 rs11159064 chr14:74614743 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 -0.75 -5.15 -0.3 5.06e-7 Morning vs. evening chronotype; CESC cis rs4332037 0.851 rs1403175 chr7:1964357 A/T cg23422044 chr7:1970798 MAD1L1 0.54 5.69 0.33 3.37e-8 Bipolar disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06767762 chr16:70323488 AARS -0.43 -6.05 -0.35 4.92e-9 Asthma; CESC cis rs938554 0.513 rs1014290 chr4:10001861 G/A cg00071950 chr4:10020882 SLC2A9 0.62 8.22 0.45 8.95e-15 Blood metabolite levels; CESC cis rs8077577 0.895 rs62073602 chr17:18057907 A/G cg16794390 chr17:18148240 FLII 0.48 6.36 0.36 8.84e-10 Obesity-related traits; CESC cis rs990171 0.506 rs4141632 chr2:102757139 A/G cg22835712 chr2:102737379 NA 0.42 6.09 0.35 3.92e-9 Lymphocyte counts; CESC cis rs854765 0.547 rs2955353 chr17:17948979 T/C cg09796270 chr17:17721594 SREBF1 -0.38 -5.07 -0.3 7.66e-7 Total body bone mineral density; CESC cis rs1915146 0.546 rs2454055 chr10:126859832 T/C cg00406319 chr10:126851303 NA 0.38 5.85 0.34 1.44e-8 Menarche (age at onset); CESC cis rs4820539 0.966 rs5751587 chr22:23470090 G/A cg14186256 chr22:23484241 RTDR1 0.83 15.0 0.68 3.12e-37 Bone mineral density; CESC trans rs3942852 0.806 rs10838805 chr11:48118993 A/C cg03929089 chr4:120376271 NA -0.56 -6.36 -0.36 9.04e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs2012796 1.000 rs8009171 chr14:81820060 G/A cg02996355 chr14:81879375 NA 0.51 5.97 0.34 7.64e-9 Night sleep phenotypes; CESC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg27286337 chr10:134555280 INPP5A 0.67 7.62 0.42 4.43e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg26441486 chr22:50317300 CRELD2 0.42 5.28 0.31 2.66e-7 Schizophrenia; CESC cis rs1008375 0.863 rs2058336 chr4:17608299 T/C cg02297831 chr4:17616191 MED28 0.52 6.53 0.37 3.27e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7208859 0.573 rs11656278 chr17:29075188 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg27266027 chr21:40555129 PSMG1 0.45 5.34 0.31 2.05e-7 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25010622 chr20:32700257 EIF2S2 0.59 7.18 0.4 6.84e-12 Gut microbiome composition (summer); CESC cis rs258892 0.895 rs10041942 chr5:72049964 T/C cg21869765 chr5:72125136 TNPO1 -0.4 -5.13 -0.3 5.56e-7 Small cell lung carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14022530 chr1:100598534 SASS6;CCDC76 0.54 6.57 0.37 2.63e-10 Gut microbiome composition (summer); CESC cis rs9325144 0.647 rs61937754 chr12:39060543 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.23 -0.41 5.23e-12 Morning vs. evening chronotype; CESC cis rs4986172 0.655 rs1044977 chr17:43227214 T/C cg10701640 chr17:43249399 NA 0.43 6.86 0.39 4.81e-11 Height; CESC cis rs6963495 0.818 rs6977748 chr7:105167462 T/G cg13798780 chr7:105162888 PUS7 0.77 7.59 0.42 5.45e-13 Bipolar disorder (body mass index interaction); CESC cis rs524281 0.861 rs9645684 chr11:65907964 G/A cg14036092 chr11:66035641 RAB1B -0.58 -5.91 -0.34 1.05e-8 Electroencephalogram traits; CESC cis rs2243480 1.000 rs35396113 chr7:65495461 C/T cg25894440 chr7:65020034 NA -0.66 -5.69 -0.33 3.42e-8 Diabetic kidney disease; CESC cis rs2425143 1.000 rs79035779 chr20:34343004 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.44 0.32 1.2e-7 Blood protein levels; CESC cis rs9616064 0.531 rs17821649 chr22:47050387 G/A cg25730555 chr22:47059586 GRAMD4 0.46 5.73 0.33 2.71e-8 Urate levels in obese individuals; CESC cis rs7044106 0.762 rs10491783 chr9:123450155 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.09 0.53 1.84e-20 Hip circumference adjusted for BMI; CESC cis rs3106136 0.967 rs12646184 chr4:95183216 A/G cg11021082 chr4:95130006 SMARCAD1 0.45 6.62 0.38 2.01e-10 Capecitabine sensitivity; CESC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg22143856 chr6:28129313 ZNF389 -0.46 -5.87 -0.34 1.28e-8 Parkinson's disease; CESC cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg26597838 chr10:835615 NA 0.94 10.04 0.53 2.57e-20 Eosinophil percentage of granulocytes; CESC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg18404041 chr3:52824283 ITIH1 -0.38 -6.49 -0.37 4.13e-10 Electroencephalogram traits; CESC cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.5 -6.23 -0.36 1.78e-9 Tonsillectomy; CESC cis rs2063714 0.967 rs913971 chr6:157197802 C/T cg23222435 chr6:157204239 ARID1B -0.39 -5.11 -0.3 6.29e-7 Sitting height ratio; CESC trans rs11098499 0.754 rs10213554 chr4:120260785 A/G cg25214090 chr10:38739885 LOC399744 -0.63 -8.91 -0.48 8.45e-17 Corneal astigmatism; CESC cis rs616402 0.527 rs604369 chr1:10567208 C/A cg20482658 chr1:10539492 PEX14 -0.28 -5.84 -0.34 1.54e-8 Breast size; CESC cis rs7727544 0.606 rs10058074 chr5:131686146 G/A cg14196790 chr5:131705035 SLC22A5 0.37 5.47 0.32 1.04e-7 Blood metabolite levels; CESC cis rs9549367 0.789 rs9549718 chr13:113909822 A/G cg18105134 chr13:113819100 PROZ -0.7 -8.49 -0.46 1.48e-15 Platelet distribution width; CESC cis rs7927592 0.731 rs2840367 chr11:68302101 G/A cg16797656 chr11:68205561 LRP5 -0.48 -7.41 -0.41 1.69e-12 Total body bone mineral density; CESC cis rs1707322 0.686 rs1084086 chr1:46041100 A/C cg03146154 chr1:46216737 IPP -0.78 -10.67 -0.55 2.34e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7202877 0.706 rs37605 chr16:75506572 G/C cg03315344 chr16:75512273 CHST6 -0.53 -5.05 -0.3 8.28e-7 Type 2 diabetes;Type 1 diabetes; CESC cis rs9815354 0.638 rs17218866 chr3:42017634 T/C cg03022575 chr3:42003672 ULK4 0.74 6.64 0.38 1.79e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs72945132 0.882 rs61260732 chr11:70162145 G/A cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17107193 chr6:5261438 LYRM4;FARS2 0.62 7.45 0.42 1.31e-12 Gut microbiome composition (summer); CESC cis rs9300255 0.722 rs28592876 chr12:123866429 G/A cg19016782 chr12:123741754 C12orf65 0.46 6.29 0.36 1.33e-9 Neutrophil percentage of white cells; CESC cis rs9389248 0.737 rs56358308 chr6:135306980 A/T cg22676075 chr6:135203613 NA 0.54 7.06 0.4 1.46e-11 High light scatter reticulocyte percentage of red cells; CESC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs763121 0.719 rs138699 chr22:39129708 G/A cg06544989 chr22:39130855 UNC84B 0.48 8.04 0.44 3.06e-14 Menopause (age at onset); CESC cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7191439 0.674 rs4782429 chr16:88792097 A/G cg02389323 chr16:88786976 FAM38A 0.93 8.34 0.46 4.01e-15 Plateletcrit; CESC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 6.5 0.37 4.03e-10 Bipolar disorder; CESC cis rs703842 1.000 rs10877014 chr12:58167661 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.71 9.41 0.5 2.48e-18 Multiple sclerosis; CESC trans rs7246760 0.748 rs113745845 chr19:9736226 G/A cg02900749 chr2:68251473 NA -0.8 -6.18 -0.35 2.43e-9 Pursuit maintenance gain; CESC cis rs10751667 0.857 rs7481221 chr11:966813 G/C cg20946044 chr11:1010712 AP2A2 -0.4 -5.46 -0.32 1.12e-7 Alzheimer's disease (late onset); CESC cis rs4561483 0.832 rs33645 chr16:11985201 T/C cg08843971 chr16:11963173 GSPT1 -0.55 -8.15 -0.45 1.5e-14 Testicular germ cell tumor; CESC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg24829409 chr8:58192753 C8orf71 -0.74 -9.68 -0.51 3.6e-19 Developmental language disorder (linguistic errors); CESC cis rs72627123 0.656 rs76479281 chr14:74564609 C/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.74 5.12 0.3 5.89e-7 Morning vs. evening chronotype; CESC cis rs3771570 0.786 rs62186396 chr2:242221219 A/G cg21155796 chr2:242212141 HDLBP 0.64 5.34 0.31 2.03e-7 Prostate cancer; CESC cis rs672059 0.513 rs572977 chr1:183164991 C/G cg06211724 chr1:183155437 LAMC2 -0.35 -5.64 -0.33 4.27e-8 Hypertriglyceridemia; CESC cis rs7561273 0.609 rs6545285 chr2:24340029 T/C cg20701182 chr2:24300061 SF3B14 0.46 6.02 0.35 5.92e-9 Quantitative traits; CESC cis rs9905704 0.633 rs72841019 chr17:56496346 G/A cg12560992 chr17:57184187 TRIM37 0.6 5.54 0.32 7.38e-8 Testicular germ cell tumor; CESC cis rs7662987 0.793 rs12106 chr4:99993350 A/G cg13256891 chr4:100009986 ADH5 -0.59 -5.12 -0.3 5.89e-7 Smoking initiation; CESC cis rs9611565 0.694 rs79008 chr22:41850500 C/T cg06634786 chr22:41940651 POLR3H -0.62 -6.36 -0.36 8.89e-10 Vitiligo; CESC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs66573146 0.572 rs73199995 chr4:6955801 G/C cg26116260 chr4:7069785 GRPEL1 -0.79 -5.16 -0.3 4.96e-7 Granulocyte percentage of myeloid white cells; CESC cis rs9549367 0.713 rs9577211 chr13:113830718 G/C cg00898013 chr13:113819073 PROZ -0.52 -7.48 -0.42 1.08e-12 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08975529 chr11:70309722 NA -0.55 -6.02 -0.35 5.72e-9 Gut microbiome composition (summer); CESC trans rs1814175 0.817 rs1851858 chr11:49855638 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -21.11 -0.79 1.04e-58 Height; CESC cis rs561341 1.000 rs546519 chr17:30297682 T/G cg12193833 chr17:30244370 NA -0.59 -6.02 -0.35 5.78e-9 Hip circumference adjusted for BMI; CESC cis rs6456156 0.586 rs2001115 chr6:167486218 A/C cg07741184 chr6:167504864 NA 0.37 6.28 0.36 1.39e-9 Primary biliary cholangitis; CESC cis rs1348850 0.567 rs4893838 chr2:178531436 T/C cg22681709 chr2:178499509 PDE11A -0.49 -7.27 -0.41 4.12e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs3749237 1.000 rs3749237 chr3:49770032 C/T cg21659725 chr3:3221576 CRBN 0.49 6.1 0.35 3.66e-9 Resting heart rate; CESC cis rs9487051 0.768 rs399561 chr6:109524979 G/A cg01475377 chr6:109611718 NA -0.46 -6.93 -0.39 3.27e-11 Reticulocyte fraction of red cells; CESC cis rs3780486 0.846 rs10813948 chr9:33121570 G/A cg13443165 chr9:33130375 B4GALT1 0.44 6.35 0.36 9.18e-10 IgG glycosylation; CESC cis rs2337406 0.714 rs7150993 chr14:107226748 A/T cg23076370 chr14:107095027 NA -0.52 -5.28 -0.31 2.68e-7 Alzheimer's disease (late onset); CESC cis rs752010 0.871 rs10890149 chr1:42092791 T/A cg06885757 chr1:42089581 HIVEP3 0.46 7.48 0.42 1.08e-12 Lupus nephritis in systemic lupus erythematosus; CESC cis rs116095464 0.558 rs10057674 chr5:266813 C/T cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.51e-10 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26860337 chr1:155178555 MTX1;THBS3 0.56 6.39 0.37 7.37e-10 Gut microbiome composition (summer); CESC cis rs9488822 0.596 rs13192549 chr6:116338352 C/A cg15226275 chr6:116381976 FRK 0.21 5.19 0.3 4.11e-7 Cholesterol, total;LDL cholesterol; CESC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg08027265 chr7:2291960 NA -0.46 -7.05 -0.4 1.6e-11 Bipolar disorder and schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09166770 chr16:30941758 FBXL19 0.5 6.76 0.38 8.91e-11 Fibrinogen levels; CESC cis rs12586317 0.620 rs28404080 chr14:35539418 G/T cg16230307 chr14:35515116 FAM177A1 0.93 9.91 0.52 6.88e-20 Psoriasis; CESC cis rs35306767 0.953 rs35174953 chr10:961191 C/A cg25019033 chr10:957182 NA -0.65 -7.87 -0.44 8.8e-14 Eosinophil percentage of granulocytes; CESC cis rs7584330 0.826 rs72620825 chr2:238381243 G/A cg14458575 chr2:238380390 NA 0.89 12.4 0.61 3.61e-28 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11704435 chr12:133281175 PXMP2 0.44 6.0 0.35 6.37e-9 Fibrinogen levels; CESC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg05457628 chr5:178986728 RUFY1 0.52 7.55 0.42 7.04e-13 Lung cancer; CESC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.49 7.26 0.41 4.3e-12 Total body bone mineral density; CESC cis rs17039065 0.920 rs11725434 chr4:109432750 G/A cg16022748 chr4:109541635 LOC285456;RPL34 0.61 5.16 0.3 4.75e-7 Gut microbiome composition (summer); CESC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg26554054 chr8:600488 NA 0.65 5.6 0.33 5.31e-8 IgG glycosylation; CESC cis rs3092073 0.624 rs13040315 chr20:44585793 A/G cg00981651 chr20:44574847 PCIF1 0.34 5.26 0.31 2.93e-7 Intelligence (multi-trait analysis); CESC cis rs941873 0.868 rs7898 chr10:81114959 C/T cg11057378 chr10:81107060 PPIF 0.32 5.24 0.31 3.25e-7 Height; CESC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg06873352 chr17:61820015 STRADA 0.71 12.11 0.6 3.8e-27 Prudent dietary pattern; CESC cis rs2073300 0.609 rs6137913 chr20:23357725 C/T cg12062639 chr20:23401060 NAPB 0.81 7.25 0.41 4.61e-12 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg11366901 chr6:160182831 ACAT2 0.78 9.9 0.52 7.06e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs11731606 0.508 rs9307140 chr4:95288670 G/C cg00507259 chr4:95128692 SMARCAD1 0.55 5.13 0.3 5.71e-7 Mean platelet volume; CESC cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg20503657 chr10:835505 NA 0.83 8.06 0.44 2.62e-14 Eosinophil percentage of granulocytes; CESC trans rs747782 0.582 rs11039571 chr11:48207259 G/A cg15704280 chr7:45808275 SEPT13 0.7 6.76 0.38 8.91e-11 Intraocular pressure; CESC cis rs3008870 1.000 rs2755248 chr1:67492624 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.02 13.83 0.65 4.01e-33 Lymphocyte percentage of white cells; CESC cis rs4822044 0.568 rs1883370 chr22:42143740 C/A cg06634786 chr22:41940651 POLR3H 0.72 7.16 0.4 8.16e-12 Cannabis dependence symptom count; CESC cis rs28374715 0.681 rs28728213 chr15:41653602 T/A cg18705301 chr15:41695430 NDUFAF1 -0.84 -12.55 -0.61 1.19e-28 Ulcerative colitis; CESC cis rs28489187 0.706 rs423105 chr1:85796427 A/G cg16011679 chr1:85725395 C1orf52 0.47 5.6 0.33 5.46e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg05896524 chr21:47604654 C21orf56 -0.47 -6.16 -0.35 2.67e-9 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.82 0.48 1.58e-16 Colonoscopy-negative controls vs population controls; CESC cis rs8180040 0.966 rs6792488 chr3:47503349 C/T cg27129171 chr3:47204927 SETD2 -0.63 -9.45 -0.5 1.86e-18 Colorectal cancer; CESC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg11764359 chr7:65958608 NA 0.68 8.78 0.47 2.05e-16 Aortic root size; CESC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg09658497 chr7:2847517 GNA12 -0.36 -5.14 -0.3 5.38e-7 Height; CESC cis rs2292864 0.764 rs2292867 chr17:45357489 C/T cg18085866 chr17:45331354 ITGB3 -0.56 -5.2 -0.3 4e-7 Left atrial antero-posterior diameter; CESC cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg13175981 chr1:150552382 MCL1 0.62 9.22 0.49 9.44e-18 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14428669 chr9:114659192 UGCG -0.44 -6.31 -0.36 1.19e-9 Fibrinogen levels; CESC cis rs10129255 0.789 rs61997796 chr14:107222031 C/T cg23076370 chr14:107095027 NA -0.45 -5.31 -0.31 2.3e-7 Kawasaki disease; CESC cis rs7666738 0.830 rs13116691 chr4:98929771 A/C cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11997175 0.598 rs4599769 chr8:33601425 T/C ch.8.33884649F chr8:33765107 NA 0.51 6.34 0.36 9.91e-10 Body mass index; CESC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg18758796 chr5:131593413 PDLIM4 0.48 5.98 0.34 7.36e-9 Breast cancer; CESC cis rs4474465 1.000 rs7927722 chr11:78210893 T/C cg02023728 chr11:77925099 USP35 -0.4 -5.18 -0.3 4.3e-7 Alzheimer's disease (survival time); CESC cis rs897984 0.609 rs35468353 chr16:31056433 A/G cg00531865 chr16:30841666 NA -0.39 -5.48 -0.32 9.95e-8 Dementia with Lewy bodies; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg01720705 chr1:231175557 FAM89A 0.43 6.0 0.35 6.29e-9 Breast cancer;Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01184139 chr5:180649358 TRIM41 0.6 6.86 0.39 4.99e-11 Gut microbiome composition (summer); CESC cis rs4727027 0.899 rs11771339 chr7:148854132 A/T cg23583168 chr7:148888333 NA -0.81 -12.68 -0.61 4.05e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2204008 0.745 rs12146863 chr12:38502346 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.46 0.54 1.15e-21 Bladder cancer; CESC cis rs116095464 0.558 rs113796397 chr5:246503 A/G cg10591111 chr5:226296 SDHA -0.53 -6.13 -0.35 3.16e-9 Breast cancer; CESC cis rs2456568 0.531 rs7105060 chr11:93661268 C/A cg26875233 chr11:93583750 C11orf90 -0.33 -5.84 -0.34 1.52e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs1153858 1.000 rs72623915 chr15:45647433 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.45e-9 Homoarginine levels; CESC cis rs13095912 0.752 rs13061708 chr3:185339984 T/C cg11274856 chr3:185301563 NA 0.37 5.51 0.32 8.61e-8 Systolic blood pressure; CESC cis rs9303401 0.614 rs17175663 chr17:57108437 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.98 12.1 0.6 4.08e-27 Cognitive test performance; CESC cis rs7927592 0.956 rs6591341 chr11:68335478 C/T cg20283391 chr11:68216788 NA -0.49 -6.13 -0.35 3.23e-9 Total body bone mineral density; CESC cis rs12479064 0.724 rs737094 chr2:100089078 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -6.67 -0.38 1.5e-10 Chronic sinus infection; CESC cis rs1568889 0.775 rs35243076 chr11:28250618 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.85 0.65 3.36e-33 Bipolar disorder; CESC cis rs11264213 0.591 rs274732 chr1:36488199 T/G cg27506609 chr1:36549197 TEKT2 -0.76 -6.97 -0.39 2.46e-11 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26595336 chr15:82338380 MEX3B -0.47 -6.34 -0.36 9.67e-10 Fibrinogen levels; CESC cis rs12541635 0.966 rs4416800 chr8:106996677 T/C cg10147462 chr8:107024639 NA 0.39 5.54 0.32 7.19e-8 Age of smoking initiation; CESC cis rs7927592 0.731 rs488381 chr11:68291693 G/A cg20283391 chr11:68216788 NA 0.44 5.53 0.32 7.51e-8 Total body bone mineral density; CESC cis rs748404 0.697 rs473554 chr15:43568207 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.82 0.43 1.29e-13 Lung cancer; CESC cis rs1153858 1.000 rs8042786 chr15:45703539 T/C cg21132104 chr15:45694354 SPATA5L1 0.86 11.69 0.58 9.6e-26 Homoarginine levels; CESC cis rs9486719 1.000 rs11752584 chr6:96884952 C/A cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC trans rs35883536 1.000 rs2050472 chr1:101125560 T/C cg16931499 chr17:42786676 DBF4B 0.42 6.14 0.35 3.05e-9 Monocyte count; CESC cis rs7520050 0.897 rs4440807 chr1:46470878 T/C cg24296786 chr1:45957014 TESK2 0.44 5.5 0.32 9.17e-8 Red blood cell count;Reticulocyte count; CESC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.83 11.56 0.58 2.7e-25 Age-related macular degeneration (geographic atrophy); CESC cis rs9911578 0.835 rs723991 chr17:56482039 G/A cg05425664 chr17:57184151 TRIM37 0.44 6.17 0.35 2.6e-9 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06503831 chr17:26634225 FLJ40504 -0.51 -6.09 -0.35 3.92e-9 Gut microbiome composition (summer); CESC cis rs2455799 0.573 rs2654648 chr3:15775425 T/C cg09340198 chr3:15902540 ANKRD28 -0.33 -5.12 -0.3 5.98e-7 Mean platelet volume; CESC cis rs8020095 0.571 rs10141947 chr14:67542678 A/G cg19548862 chr14:67692701 FAM71D -0.51 -6.26 -0.36 1.57e-9 Depression (quantitative trait); CESC cis rs854765 0.964 rs854813 chr17:18003845 C/T cg16928487 chr17:17741425 SREBF1 0.57 9.57 0.51 7.75e-19 Total body bone mineral density; CESC cis rs3733585 0.631 rs4697925 chr4:10124330 G/C cg11266682 chr4:10021025 SLC2A9 -0.56 -10.04 -0.52 2.64e-20 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg26335602 chr6:28129616 ZNF389 0.44 5.66 0.33 3.97e-8 Parkinson's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01184139 chr5:180649358 TRIM41 -0.46 -6.23 -0.36 1.79e-9 Fibrinogen levels; CESC cis rs8070624 0.543 rs7219320 chr17:17880877 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.59 7.69 0.43 2.97e-13 Total body bone mineral density; CESC cis rs832540 0.898 rs252890 chr5:56226410 T/C cg14703610 chr5:56206110 C5orf35 0.53 7.12 0.4 1.01e-11 Coronary artery disease; CESC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg07677032 chr17:61819896 STRADA 0.45 5.64 0.33 4.34e-8 Height; CESC cis rs1801251 1.000 rs6714245 chr2:233580505 T/C cg25237894 chr2:233734115 C2orf82 0.49 8.11 0.45 1.84e-14 Coronary artery disease; CESC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg16145915 chr7:1198662 ZFAND2A -0.47 -6.56 -0.37 2.79e-10 Longevity;Endometriosis; CESC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg12516959 chr21:47718080 NA 0.34 5.14 0.3 5.4e-7 Testicular germ cell tumor; CESC cis rs1692580 0.846 rs377599 chr1:2164699 C/T cg04315214 chr1:2043799 PRKCZ -0.37 -5.31 -0.31 2.37e-7 Coronary artery disease; CESC cis rs9911578 0.967 rs72628392 chr17:56506160 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.1 -0.3 6.62e-7 Intelligence (multi-trait analysis); CESC cis rs6502050 0.835 rs67634087 chr17:80118168 C/T cg11859384 chr17:80120422 CCDC57 -0.41 -5.71 -0.33 3.03e-8 Life satisfaction; CESC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.25e-30 Prudent dietary pattern; CESC cis rs17376456 1.000 rs17323433 chr5:93551028 G/A cg21475434 chr5:93447410 FAM172A 0.86 7.53 0.42 7.93e-13 Diabetic retinopathy; CESC cis rs9811920 0.809 rs6806323 chr3:99722564 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.4 -5.19 -0.3 4.27e-7 Axial length; CESC cis rs8060686 0.516 rs7193701 chr16:68185160 A/G cg01866162 chr16:67596514 CTCF -0.46 -5.05 -0.3 8.11e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs752010 0.695 rs11210508 chr1:42106935 A/G cg06885757 chr1:42089581 HIVEP3 0.49 7.86 0.43 9.43e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs4844614 0.904 rs6686325 chr1:207833357 G/A cg21110645 chr1:207815933 NA 0.41 6.48 0.37 4.37e-10 LDL cholesterol; CESC trans rs11098499 0.863 rs10013305 chr4:120450424 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.47e-19 Corneal astigmatism; CESC cis rs2011503 1.000 rs4808205 chr19:19645493 T/G cg11584989 chr19:19387371 SF4 0.56 6.29 0.36 1.33e-9 Bipolar disorder; CESC cis rs9329221 0.537 rs6983332 chr8:9977918 A/G cg21625330 chr8:9911636 MSRA 0.42 5.49 0.32 9.5e-8 Neuroticism; CESC cis rs2242116 0.796 rs4587 chr3:46963502 T/C cg02527881 chr3:46936655 PTH1R -0.51 -7.13 -0.4 9.47e-12 Birth weight; CESC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -6.91 -0.39 3.66e-11 Bipolar disorder and schizophrenia; CESC cis rs7219021 1.000 rs72831853 chr17:46842575 A/T cg16584676 chr17:46985605 UBE2Z -0.68 -7.51 -0.42 9.12e-13 Schizophrenia or bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26926632 chr1:150848739 ARNT -0.45 -6.05 -0.35 4.99e-9 Fibrinogen levels; CESC cis rs79839061 0.563 rs55728587 chr4:843674 G/A cg07828340 chr4:882639 GAK 1.09 8.29 0.45 5.76e-15 Intelligence (multi-trait analysis); CESC cis rs3820068 0.608 rs12760450 chr1:16037282 G/A cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.52e-7 Systolic blood pressure; CESC cis rs2415984 0.579 rs10151988 chr14:46955203 C/T cg14871534 chr14:47121158 RPL10L -0.34 -5.27 -0.31 2.85e-7 Number of children ever born; CESC cis rs796364 0.664 rs4673660 chr2:200915395 C/T cg23649088 chr2:200775458 C2orf69 0.66 6.94 0.39 3.05e-11 Schizophrenia; CESC cis rs10733682 0.659 rs4358894 chr9:129464802 C/G cg00232160 chr9:129468157 NA 0.39 6.22 0.36 1.9e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg23034840 chr1:205782522 SLC41A1 -0.64 -7.82 -0.43 1.29e-13 Menarche (age at onset); CESC cis rs6570726 0.935 rs12663211 chr6:145818427 G/A cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs116095464 0.558 rs10058428 chr5:235608 A/G cg22857025 chr5:266934 NA -1.29 -18.85 -0.76 7.33e-51 Breast cancer; CESC cis rs9768139 0.733 rs13309363 chr7:158122179 C/A cg25566285 chr7:158114605 PTPRN2 0.49 8.05 0.44 2.9e-14 Calcium levels; CESC cis rs2730245 1.000 rs2657345 chr7:158744169 T/C cg15303052 chr7:158526867 ESYT2 0.42 5.12 0.3 5.86e-7 Height; CESC cis rs6665290 0.558 rs1319103 chr1:227219314 A/G cg10327440 chr1:227177885 CDC42BPA -0.76 -11.29 -0.57 2.07e-24 Myeloid white cell count; CESC cis rs9640161 0.830 rs17173682 chr7:150059602 A/G cg17279839 chr7:150038598 RARRES2 0.41 5.31 0.31 2.33e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs10870270 1.000 rs11146324 chr10:133767445 A/C cg17892150 chr10:133769511 PPP2R2D -0.86 -12.59 -0.61 8.22e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg04944784 chr2:26401820 FAM59B 0.96 10.55 0.54 5.79e-22 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15947599 chr18:9478638 RALBP1 -0.59 -6.23 -0.36 1.84e-9 Gut microbiome composition (summer); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg16678153 chr1:82265969 LPHN2 -0.47 -6.42 -0.37 6.24e-10 Thyroid stimulating hormone; CESC cis rs938554 0.784 rs13131257 chr4:9981889 T/C cg11266682 chr4:10021025 SLC2A9 0.36 5.06 0.3 7.84e-7 Blood metabolite levels; CESC trans rs1814175 0.791 rs1722023 chr11:49908136 G/C cg03929089 chr4:120376271 NA -0.93 -16.26 -0.71 1.03e-41 Height; CESC cis rs950776 0.518 rs12900783 chr15:78815523 G/A cg06917634 chr15:78832804 PSMA4 0.79 11.88 0.59 2.16e-26 Sudden cardiac arrest; CESC trans rs7849270 0.959 rs3124509 chr9:131896999 C/T cg05583848 chr6:35265411 DEF6 0.45 6.26 0.36 1.53e-9 Blood metabolite ratios; CESC cis rs2742417 0.603 rs2742395 chr3:45758595 A/G cg04837898 chr3:45731254 SACM1L -0.49 -6.49 -0.37 4.14e-10 Response to anti-depressant treatment in major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27152661 chr10:99052555 ARHGAP19 -0.66 -7.86 -0.43 9.47e-14 Gut microbiome composition (summer); CESC trans rs10506458 0.915 rs17687426 chr12:63397900 G/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.32 -18.25 -0.75 9.19e-49 Hemostatic factors and hematological phenotypes; CESC cis rs2073300 1.000 rs12626013 chr20:23442215 G/A cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg27398817 chr8:82754497 SNX16 0.55 6.34 0.36 1.01e-9 Diastolic blood pressure; CESC cis rs9640161 0.783 rs1132261 chr7:150059987 G/A cg17279839 chr7:150038598 RARRES2 0.43 5.43 0.32 1.3e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg18876405 chr7:65276391 NA -0.57 -7.63 -0.42 4.14e-13 Aortic root size; CESC cis rs11997175 0.597 rs4472473 chr8:33610255 A/G ch.8.33884649F chr8:33765107 NA 0.54 6.88 0.39 4.27e-11 Body mass index; CESC cis rs5769765 0.542 rs761878 chr22:50249677 A/G cg02269571 chr22:50332266 NA 0.48 5.6 0.33 5.36e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01618530 chr8:54755981 ATP6V1H 0.65 7.16 0.4 7.89e-12 Gut microbiome composition (summer); CESC cis rs2073300 0.609 rs2281434 chr20:23378101 C/A cg16736954 chr20:23401023 NAPB 0.8 6.25 0.36 1.67e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg07507251 chr3:52567010 NT5DC2 0.31 5.39 0.31 1.57e-7 Electroencephalogram traits; CESC cis rs34779708 0.966 rs11010095 chr10:35395948 A/G cg04310649 chr10:35416472 CREM -0.53 -6.4 -0.37 7.11e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs17799476 0.938 rs72808770 chr2:46361322 G/A cg12428440 chr2:46370979 PRKCE 0.55 5.42 0.32 1.34e-7 Hemoglobin concentration;Hematocrit; CESC cis rs4604732 0.527 rs12031949 chr1:247624463 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.4 0.37 6.94e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2617583 0.967 rs2550947 chr5:1450506 T/C cg07151155 chr5:1473589 LPCAT1 -0.36 -5.52 -0.32 7.96e-8 Breast cancer; CESC cis rs11785400 0.793 rs9297970 chr8:143723386 C/T cg10596483 chr8:143751796 JRK 0.42 5.36 0.31 1.77e-7 Schizophrenia; CESC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg22535103 chr8:58192502 C8orf71 -0.95 -10.54 -0.54 6.39e-22 Developmental language disorder (linguistic errors); CESC cis rs9814567 0.896 rs4435682 chr3:134344182 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.43 5.74 0.33 2.6e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7927592 0.830 rs10896339 chr11:68302846 G/C cg20283391 chr11:68216788 NA -0.49 -6.23 -0.36 1.82e-9 Total body bone mineral density; CESC cis rs933688 0.938 rs10942634 chr5:90658392 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.1 15.48 0.69 6.1e-39 Smoking behavior; CESC cis rs7772486 0.790 rs2814879 chr6:146201743 T/C cg23711669 chr6:146136114 FBXO30 0.9 13.27 0.63 3.71e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg00784671 chr22:46762841 CELSR1 -0.49 -5.67 -0.33 3.76e-8 LDL cholesterol;Cholesterol, total; CESC cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.62 -5.91 -0.34 1.05e-8 Schizophrenia; CESC cis rs7116495 1.000 rs10793016 chr11:71755063 A/G cg10381502 chr11:71823885 C11orf51 0.62 5.34 0.31 2.03e-7 Severe influenza A (H1N1) infection; CESC cis rs61759167 0.774 rs61759173 chr1:3097509 C/T cg01961086 chr1:3086487 PRDM16 -0.35 -5.15 -0.3 5.19e-7 Motion sickness; CESC cis rs17253792 0.822 rs10133962 chr14:56066088 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg08859206 chr1:53392774 SCP2 -0.56 -7.35 -0.41 2.4e-12 Monocyte count; CESC cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg21573476 chr21:45109991 RRP1B -0.57 -8.14 -0.45 1.52e-14 Mean corpuscular volume; CESC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs9309711 0.772 rs9752251 chr2:3489869 C/T cg10845886 chr2:3471009 TTC15 -0.79 -10.42 -0.54 1.62e-21 Neurofibrillary tangles; CESC cis rs7107174 1.000 rs2248407 chr11:77937800 G/A cg02023728 chr11:77925099 USP35 0.46 6.55 0.37 2.9e-10 Testicular germ cell tumor; CESC cis rs2243480 1.000 rs316317 chr7:65613637 G/T cg13147721 chr7:65941812 NA -0.97 -9.14 -0.49 1.7e-17 Diabetic kidney disease; CESC cis rs8067354 0.574 rs1295923 chr17:57960436 A/G cg13753209 chr17:57696993 CLTC 0.55 5.84 0.34 1.49e-8 Hemoglobin concentration; CESC cis rs14403 1.000 rs55655818 chr1:243661222 G/T cg21452805 chr1:244014465 NA 0.49 5.58 0.32 5.8e-8 Schizophrenia; CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg17372223 chr3:52568218 NT5DC2 0.46 7.21 0.4 5.95e-12 Electroencephalogram traits; CESC cis rs12971120 0.947 rs3764509 chr18:72167124 C/G cg26446133 chr18:72167187 CNDP2 -0.74 -11.03 -0.56 1.55e-23 Refractive error; CESC cis rs1559088 1.000 rs12985438 chr19:33559368 G/A cg17764715 chr19:33622953 WDR88 0.47 5.78 0.33 2.13e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.8 0.48 1.78e-16 Intelligence (multi-trait analysis); CESC cis rs854765 0.964 rs12950562 chr17:17995166 C/T cg16928487 chr17:17741425 SREBF1 0.55 9.18 0.49 1.24e-17 Total body bone mineral density; CESC cis rs870825 0.616 rs7680835 chr4:185652992 C/G cg04058563 chr4:185651563 MLF1IP -0.63 -7.15 -0.4 8.3e-12 Blood protein levels; CESC cis rs6088580 0.584 rs2378203 chr20:32993846 A/T cg08999081 chr20:33150536 PIGU -0.64 -10.99 -0.56 2.09e-23 Glomerular filtration rate (creatinine); CESC cis rs2760061 0.569 rs621631 chr1:228114728 A/G cg01973587 chr1:228161476 NA 0.35 5.32 0.31 2.17e-7 Diastolic blood pressure; CESC cis rs514406 0.893 rs1242317 chr1:53414766 T/C cg25767906 chr1:53392781 SCP2 -0.43 -5.36 -0.31 1.77e-7 Monocyte count; CESC cis rs2228479 0.867 rs11645970 chr16:89958118 G/A cg00800038 chr16:89945340 TCF25 -0.87 -7.73 -0.43 2.3e-13 Skin colour saturation; CESC cis rs1044826 0.692 rs169824 chr3:139235006 G/C cg15131784 chr3:139108705 COPB2 -0.41 -5.04 -0.3 8.83e-7 Obesity-related traits; CESC cis rs6835098 0.500 rs13112928 chr4:174158132 A/G cg08422745 chr4:174089978 GALNT7 0.55 7.04 0.4 1.66e-11 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg03433033 chr1:76189801 ACADM -0.57 -6.26 -0.36 1.59e-9 Blood metabolite levels;Acylcarnitine levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25679743 chr19:42412463 NA 0.45 7.16 0.4 7.71e-12 Fibrinogen levels; CESC cis rs8077577 0.747 rs7215678 chr17:18139793 A/C cg16794390 chr17:18148240 FLII -0.43 -6.28 -0.36 1.36e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21817075 chr14:105647734 NUDT14 0.56 6.31 0.36 1.17e-9 Gut microbiome composition (summer); CESC cis rs9818941 0.824 rs7427551 chr3:157725242 C/T cg08654915 chr3:157813417 NA -0.45 -7.57 -0.42 6.11e-13 Height; CESC trans rs677673 1.000 rs677673 chr20:10481772 A/T cg16021678 chr13:55475951 NA 0.52 6.62 0.38 2.03e-10 Body mass index (change over time) in chronic obstructive pulmonary disease; CESC cis rs3736485 0.934 rs114641722 chr15:51863572 G/A cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs17095355 0.818 rs6584970 chr10:111847820 A/G cg00817464 chr10:111662876 XPNPEP1 -0.48 -5.5 -0.32 8.92e-8 Biliary atresia; CESC cis rs7824557 0.767 rs3808509 chr8:11163256 G/T cg21775007 chr8:11205619 TDH 0.49 7.14 0.4 8.87e-12 Retinal vascular caliber; CESC cis rs13191362 0.507 rs2849527 chr6:163117932 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.57 6.91 0.39 3.58e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8018808 0.967 rs176766 chr14:77865367 G/A cg20045696 chr14:77926864 AHSA1 0.38 5.17 0.3 4.56e-7 Myeloid white cell count; CESC cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg17143192 chr8:8559678 CLDN23 -0.68 -8.26 -0.45 7.19e-15 Obesity-related traits; CESC cis rs763121 0.853 rs2413546 chr22:39107001 G/A cg14440974 chr22:39074834 NA -0.42 -5.73 -0.33 2.69e-8 Menopause (age at onset); CESC cis rs13418410 0.539 rs35866672 chr2:33842174 G/A cg04131969 chr2:33951647 MYADML -0.65 -7.95 -0.44 5.34e-14 Non-response to antidepressants and depression; CESC trans rs4904167 0.841 rs7145105 chr14:84677705 C/A cg06870609 chr15:89787223 FANCI 0.46 6.06 0.35 4.73e-9 Autism spectrum disorder or schizophrenia; CESC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg11663144 chr21:46675770 NA -0.63 -9.84 -0.52 1.12e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg24110177 chr3:50126178 RBM5 0.55 7.61 0.42 4.8e-13 Intelligence (multi-trait analysis); CESC cis rs3857067 0.967 rs964843 chr4:95032367 G/A cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.61 -0.42 4.77e-13 QT interval; CESC cis rs2250402 0.510 rs2898984 chr15:40324075 G/C cg10636054 chr15:40330586 SRP14 0.9 6.95 0.39 2.79e-11 Corneal curvature; CESC cis rs7998202 0.667 rs188166 chr13:113355498 T/C cg02820901 chr13:113351484 ATP11A 0.65 5.78 0.33 2.05e-8 Glycated hemoglobin levels; CESC cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg19912559 chr1:40204330 PPIE -0.41 -6.33 -0.36 1.06e-9 Blood protein levels; CESC cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg05340658 chr4:99064831 C4orf37 0.84 13.04 0.63 2.35e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs9905432 chr17:37555918 C/A cg15445000 chr17:37608096 MED1 -0.41 -6.74 -0.38 9.67e-11 Glomerular filtration rate (creatinine); CESC cis rs10911232 0.520 rs10797831 chr1:183036816 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.77 0.65 6.86e-33 Hypertriglyceridemia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12868349 chr11:71639594 RNF121;LOC100133315 -0.44 -6.35 -0.36 9.29e-10 Gambling; CESC cis rs854765 0.583 rs7207043 chr17:17819188 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.56 7.99 0.44 4.08e-14 Total body bone mineral density; CESC trans rs7618501 0.602 rs10049087 chr3:50123417 A/G cg21659725 chr3:3221576 CRBN -0.53 -7.36 -0.41 2.33e-12 Intelligence (multi-trait analysis); CESC cis rs7662987 0.517 rs2851260 chr4:100033574 C/T cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg06074448 chr4:187884817 NA 0.35 5.14 0.3 5.41e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs5753618 0.504 rs5753669 chr22:31905819 T/G cg02404636 chr22:31891804 SFI1 0.43 5.9 0.34 1.1e-8 Colorectal cancer; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg07210466 chr3:33444388 UBP1 0.46 6.21 0.36 2.1e-9 Thyroid stimulating hormone; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11227541 chr1:84972317 GNG5;SPATA1 -0.6 -7.27 -0.41 4.04e-12 Gut microbiome composition (summer); CESC cis rs10838687 0.800 rs1051006 chr11:47306585 C/T cg25783544 chr11:47291846 MADD 0.54 6.3 0.36 1.24e-9 Proinsulin levels; CESC cis rs55794721 0.509 rs4649085 chr1:25778832 G/A cg27572855 chr1:25598939 RHD 0.49 8.31 0.45 4.97e-15 Plateletcrit;Mean corpuscular volume; CESC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.33 -0.31 2.07e-7 Lung cancer; CESC cis rs7089973 0.604 rs17663670 chr10:116596269 A/C cg03647239 chr10:116582469 FAM160B1 -0.45 -5.62 -0.33 4.86e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs7319075 0.657 rs9533543 chr13:44173400 A/G cg03288419 chr19:35225464 ZNF181 0.49 6.01 0.35 6.18e-9 Photic sneeze reflex; CESC cis rs11252926 0.674 rs11598550 chr10:504778 A/C cg03684893 chr10:554711 DIP2C 0.42 6.34 0.36 9.78e-10 Psychosis in Alzheimer's disease; CESC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.88 0.34 1.23e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3733585 0.605 rs4697708 chr4:10121189 A/G cg05927159 chr4:10118984 WDR1 0.34 5.09 0.3 6.76e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8072100 1.000 rs8072100 chr17:45674687 A/T cg08085267 chr17:45401833 C17orf57 0.44 5.87 0.34 1.29e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7017914 0.967 rs7012404 chr8:71668698 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs6456156 0.692 rs9457270 chr6:167512928 A/G cg07741184 chr6:167504864 NA 0.42 7.37 0.41 2.11e-12 Primary biliary cholangitis; CESC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg07092213 chr7:1199455 ZFAND2A -0.46 -5.31 -0.31 2.27e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.68 -7.8 -0.43 1.43e-13 Gut microbiome composition (summer); CESC cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg23711669 chr6:146136114 FBXO30 0.93 12.45 0.61 2.59e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg22862634 chr11:62369728 EML3;MTA2 0.6 8.14 0.45 1.58e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg09323728 chr8:95962352 TP53INP1 -0.41 -9.06 -0.49 2.87e-17 Type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg16773294 chr8:55048378 MRPL15 -0.47 -6.56 -0.37 2.89e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg10691866 chr7:65817282 TPST1 -0.31 -5.04 -0.3 8.79e-7 Aortic root size; CESC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg17221315 chr6:27791827 HIST1H4J 0.43 5.42 0.32 1.32e-7 Parkinson's disease; CESC cis rs2380220 0.751 rs117986000 chr6:95923454 A/C cg15832292 chr6:96025679 MANEA -0.63 -5.59 -0.32 5.56e-8 Behavioural disinhibition (generation interaction); CESC cis rs854765 0.583 rs11078404 chr17:17820487 A/T cg09796270 chr17:17721594 SREBF1 0.42 5.95 0.34 8.29e-9 Total body bone mineral density; CESC cis rs2243480 1.000 rs7787230 chr7:65629099 G/A cg13147721 chr7:65941812 NA 0.97 9.19 0.49 1.2e-17 Diabetic kidney disease; CESC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg26314531 chr2:26401878 FAM59B 0.6 5.52 0.32 8.02e-8 Gut microbiome composition (summer); CESC cis rs7424096 0.527 rs4670637 chr2:37164857 T/G cg14987922 chr2:37194071 STRN 0.43 5.36 0.31 1.8e-7 High light scatter reticulocyte percentage of red cells; CESC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg22800045 chr5:56110881 MAP3K1 -0.58 -7.4 -0.41 1.84e-12 Type 2 diabetes; CESC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg08470875 chr2:26401718 FAM59B 0.59 6.16 0.35 2.76e-9 Gut microbiome composition (summer); CESC cis rs9892942 1 rs9892942 chr17:27178761 C/T cg20469991 chr17:27169893 C17orf63 -0.44 -5.26 -0.31 2.97e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01860753 chr1:206730586 RASSF5 0.49 6.11 0.35 3.52e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7267979 0.816 rs3746337 chr20:25208272 C/T cg08601574 chr20:25228251 PYGB 0.41 5.72 0.33 2.87e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9303401 0.659 rs34382037 chr17:56643550 G/T cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.56e-29 Cognitive test performance; CESC cis rs40363 0.951 rs72778117 chr16:3531827 T/C cg00484396 chr16:3507460 NAT15 0.6 7.58 0.42 5.84e-13 Tuberculosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00815862 chr16:88851914 FAM38A 0.58 6.54 0.37 3.2e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10992590 chr2:130940487 SMPD4;FAM128B 0.54 6.3 0.36 1.2e-9 Gut microbiome composition (summer); CESC cis rs858239 0.600 rs7799422 chr7:23128413 G/A cg23682824 chr7:23144976 KLHL7 0.55 7.61 0.42 4.84e-13 Cerebrospinal fluid biomarker levels; CESC cis rs7520050 0.966 rs11211241 chr1:46452683 T/A cg03146154 chr1:46216737 IPP -0.47 -6.03 -0.35 5.46e-9 Red blood cell count;Reticulocyte count; CESC cis rs6088580 0.634 rs6119497 chr20:33012529 T/A cg24642439 chr20:33292090 TP53INP2 0.53 6.95 0.39 2.87e-11 Glomerular filtration rate (creatinine); CESC trans rs7246760 0.867 rs2336090 chr19:9879584 A/G cg02900749 chr2:68251473 NA -0.72 -6.61 -0.38 2.11e-10 Pursuit maintenance gain; CESC cis rs1665050 0.534 rs8031213 chr15:59239897 A/G cg05156742 chr15:59063176 FAM63B 0.48 6.08 0.35 4.08e-9 Atopic dermatitis; CESC cis rs10504229 0.679 rs72649132 chr8:58054615 G/A cg02725872 chr8:58115012 NA -0.41 -5.95 -0.34 8.38e-9 Developmental language disorder (linguistic errors); CESC cis rs7937682 0.632 rs11214029 chr11:111761230 C/T cg09085632 chr11:111637200 PPP2R1B 0.84 10.18 0.53 9.16e-21 Primary sclerosing cholangitis; CESC cis rs6866344 0.697 rs6873150 chr5:178125704 G/A cg03877680 chr5:178157825 ZNF354A 0.7 8.13 0.45 1.66e-14 Neutrophil percentage of white cells; CESC cis rs2380220 0.808 rs2613551 chr6:95914740 G/A cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs6582630 0.502 rs4309219 chr12:38293584 A/G cg26384229 chr12:38710491 ALG10B 0.64 9.48 0.5 1.53e-18 Drug-induced liver injury (flucloxacillin); CESC cis rs9649465 1.000 rs2109723 chr7:123325339 A/G cg04330084 chr7:123175371 IQUB -0.38 -5.16 -0.3 4.75e-7 Migraine; CESC cis rs1538970 0.962 rs7532762 chr1:45864695 C/A cg24296786 chr1:45957014 TESK2 -0.45 -5.45 -0.32 1.13e-7 Platelet count; CESC cis rs9549367 0.713 rs1323315 chr13:113859658 T/C cg18105134 chr13:113819100 PROZ 0.55 7.33 0.41 2.81e-12 Platelet distribution width; CESC cis rs365132 1.000 rs353493 chr5:176432585 T/C cg16309518 chr5:176445507 NA -0.37 -5.35 -0.31 1.9e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs2268241 0.938 rs17879003 chr21:34778527 C/T cg14850771 chr21:34775459 IFNGR2 0.93 11.19 0.57 4.47e-24 Obesity-related traits; CESC cis rs6732160 0.650 rs7560224 chr2:73406182 A/G cg01422370 chr2:73384389 NA 0.45 7.7 0.43 2.8e-13 Intelligence (multi-trait analysis); CESC cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg24634471 chr8:143751801 JRK -0.44 -5.08 -0.3 7.3e-7 Urinary tract infection frequency; CESC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs7560272 0.538 rs11126414 chr2:73932044 G/A cg20560298 chr2:73613845 ALMS1 0.47 6.47 0.37 4.84e-10 Schizophrenia; CESC cis rs3857067 0.806 rs12507575 chr4:95114920 T/C cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC cis rs992157 0.798 rs2382818 chr2:219155907 A/T cg00012203 chr2:219082015 ARPC2 -0.74 -9.58 -0.51 7.54e-19 Colorectal cancer; CESC cis rs9457247 0.561 rs916331 chr6:167470559 T/G cg23791538 chr6:167370224 RNASET2 -0.52 -6.9 -0.39 3.81e-11 Crohn's disease; CESC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.24 -0.41 4.79e-12 Developmental language disorder (linguistic errors); CESC cis rs3096299 0.702 rs2086824 chr16:89471246 G/T cg08822215 chr16:89438651 ANKRD11 0.37 5.37 0.31 1.73e-7 Multiple myeloma (IgH translocation); CESC cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg25427524 chr10:38739819 LOC399744 -0.67 -9.9 -0.52 7.2e-20 Extrinsic epigenetic age acceleration; CESC cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg04450456 chr4:17643702 FAM184B 0.37 5.3 0.31 2.47e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1005277 0.540 rs11011351 chr10:38030525 A/G cg25517755 chr10:38738941 LOC399744 -0.4 -5.14 -0.3 5.34e-7 Extrinsic epigenetic age acceleration; CESC cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 6.18e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg24250549 chr1:154909240 PMVK -0.62 -8.97 -0.48 5.67e-17 Prostate cancer; CESC cis rs8053891 0.615 rs3794695 chr16:72097827 C/T cg16558253 chr16:72132732 DHX38 -0.54 -6.34 -0.36 1.01e-9 Coronary artery disease; CESC cis rs77697190 1.000 rs76097782 chr14:103842702 A/G cg09975044 chr14:104007538 NA -0.8 -5.15 -0.3 5.09e-7 Mean corpuscular hemoglobin; CESC cis rs4253772 0.938 rs14842 chr22:46639457 A/T cg00784671 chr22:46762841 CELSR1 -0.57 -5.61 -0.33 5.1e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4595586 0.545 rs67985200 chr12:39386891 C/T cg26384229 chr12:38710491 ALG10B 0.62 8.69 0.47 3.89e-16 Morning vs. evening chronotype; CESC cis rs1790761 0.505 rs7927657 chr11:67346988 T/C cg00290607 chr11:67383545 NA -0.36 -5.33 -0.31 2.14e-7 Mean corpuscular volume; CESC trans rs62103177 0.789 rs7242289 chr18:77603291 C/T cg05926928 chr17:57297772 GDPD1 1.14 11.65 0.58 1.38e-25 Opioid sensitivity; CESC cis rs1580019 0.844 rs1901202 chr7:32503724 A/T cg06627557 chr7:32535165 LSM5;AVL9 0.89 12.61 0.61 7.03e-29 Cognitive ability; CESC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg23758822 chr17:41437982 NA 1.03 15.1 0.68 1.32e-37 Menopause (age at onset); CESC cis rs7086627 0.515 rs10887895 chr10:82210011 A/G cg00277334 chr10:82204260 NA -0.91 -15.92 -0.7 1.67e-40 Post bronchodilator FEV1; CESC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg02569458 chr12:86230093 RASSF9 0.51 7.79 0.43 1.5700000000000001e-13 Major depressive disorder; CESC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg01017244 chr2:74357527 NA -0.48 -6.52 -0.37 3.48e-10 Gestational age at birth (maternal effect); CESC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg22535103 chr8:58192502 C8orf71 -0.84 -8.74 -0.47 2.73e-16 Developmental language disorder (linguistic errors); CESC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.33 0.31 2.07e-7 Tonsillectomy; CESC cis rs2735413 0.958 rs1922611 chr16:78053121 C/T cg04733911 chr16:78082701 NA -0.41 -6.12 -0.35 3.29e-9 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.77 6.5 0.37 3.97e-10 Platelet count; CESC cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.15 -0.4 8.43e-12 Total body bone mineral density; CESC cis rs4711336 1.000 rs11759396 chr6:33656654 C/G cg14003231 chr6:33640908 ITPR3 0.32 5.44 0.32 1.22e-7 Height; CESC cis rs644799 0.526 rs693172 chr11:95636618 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.54 7.18 0.4 7.07e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs9399401 1.000 rs1040525 chr6:142703669 C/T cg15730116 chr12:76953768 OSBPL8 -0.43 -6.22 -0.36 1.89e-9 Chronic obstructive pulmonary disease; CESC cis rs9527 0.590 rs1926037 chr10:104878010 A/C cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05306024 chr7:127292158 SND1 0.6 6.59 0.38 2.31e-10 Gut microbiome composition (summer); CESC cis rs6733011 0.502 rs6542847 chr2:99573471 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.43 -5.4 -0.31 1.46e-7 Bipolar disorder; CESC cis rs11792861 0.781 rs838835 chr9:111758590 A/G cg13535736 chr9:111863775 C9orf5 0.4 5.42 0.32 1.31e-7 Menarche (age at onset); CESC cis rs2019216 0.521 rs12449447 chr17:21888786 C/T cg22648282 chr17:21454238 C17orf51 -0.42 -5.44 -0.32 1.24e-7 Pelvic organ prolapse; CESC cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg25072359 chr17:41440525 NA 0.45 6.04 0.35 5.14e-9 Menopause (age at onset); CESC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg04267008 chr7:1944627 MAD1L1 -0.51 -6.12 -0.35 3.44e-9 Schizophrenia; CESC cis rs72781680 0.851 rs12612830 chr2:24134599 C/T cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg03690763 chr11:133734501 NA 0.32 5.38 0.31 1.67e-7 Childhood ear infection; CESC cis rs4595586 0.545 rs7970307 chr12:39380760 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs1775715 0.737 rs1541260 chr10:32105570 C/T cg18675610 chr10:32216311 ARHGAP12 0.34 5.27 0.31 2.85e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.41 -5.28 -0.31 2.63e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.21 0.4 5.88e-12 Height; CESC cis rs9457247 0.935 rs427824 chr6:167403918 T/G cg23791538 chr6:167370224 RNASET2 -0.58 -8.27 -0.45 6.59e-15 Crohn's disease; CESC cis rs7845219 0.544 rs7001535 chr8:95921090 C/G cg09323728 chr8:95962352 TP53INP1 -0.32 -6.23 -0.36 1.8e-9 Type 2 diabetes; CESC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg10351095 chr21:47802916 PCNT -0.41 -5.21 -0.3 3.87e-7 Testicular germ cell tumor; CESC cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg14784868 chr12:69753453 YEATS4 0.84 13.21 0.63 6.15e-31 Blood protein levels; CESC cis rs10979 0.679 rs2275345 chr6:143872960 G/A cg25407410 chr6:143891975 LOC285740 -0.53 -7.62 -0.42 4.6e-13 Hypospadias; CESC cis rs7680126 0.596 rs10020887 chr4:10140751 C/G cg00071950 chr4:10020882 SLC2A9 -0.55 -6.19 -0.36 2.3e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.7 6.67 0.38 1.48e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3820068 0.705 rs11584209 chr1:15885041 G/T cg17385448 chr1:15911702 AGMAT 0.38 5.79 0.34 1.95e-8 Systolic blood pressure; CESC cis rs9308433 0.529 rs4655333 chr1:214493549 A/G cg06198575 chr1:214491504 SMYD2 0.45 5.45 0.32 1.15e-7 IgG glycosylation; CESC cis rs6968419 0.755 rs73452247 chr7:115893897 T/C cg02561103 chr7:115862891 TES -0.4 -5.26 -0.31 2.92e-7 Intraocular pressure; CESC cis rs2228479 0.557 rs62056064 chr16:89903843 G/A cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs2540647 1.000 rs2540648 chr22:18967349 A/G cg12798833 chr22:18958832 DGCR5 0.75 7.43 0.42 1.52e-12 Blood metabolite ratios; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03987890 chr16:69420050 TERF2 -0.48 -6.13 -0.35 3.25e-9 Asthma; CESC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg08888203 chr3:10149979 C3orf24 0.51 5.99 0.35 6.84e-9 Alzheimer's disease; CESC cis rs1577917 0.958 rs12198876 chr6:86525476 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.51 -6.68 -0.38 1.41e-10 Response to antipsychotic treatment; CESC cis rs7264396 0.635 rs2425166 chr20:34439391 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.51 -0.58 3.81e-25 Total cholesterol levels; CESC cis rs12541635 0.639 rs6469030 chr8:107030321 C/T cg10147462 chr8:107024639 NA 0.44 6.5 0.37 3.98e-10 Age of smoking initiation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08491733 chr2:128051434 ERCC3 -0.48 -6.35 -0.36 9.34e-10 Fibrinogen levels; CESC cis rs6120849 0.615 rs11167248 chr20:33538721 G/T cg24642439 chr20:33292090 TP53INP2 0.69 6.83 0.39 5.7e-11 Protein C levels; CESC cis rs853679 0.825 rs8180562 chr6:28141460 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.79 6.91 0.39 3.68e-11 Depression; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13411962 chr8:28243934 ZNF395 -0.42 -6.04 -0.35 5.14e-9 Fibrinogen levels; CESC cis rs10484885 0.877 rs17735389 chr6:90323139 G/T cg13799429 chr6:90582589 CASP8AP2 -0.52 -5.29 -0.31 2.57e-7 QRS interval (sulfonylurea treatment interaction); CESC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs637571 0.607 rs574586 chr11:65697083 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.72 9.83 0.52 1.18e-19 Eosinophil percentage of white cells; CESC cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg04455712 chr21:45112962 RRP1B 0.49 7.5 0.42 9.42e-13 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18673825 chr12:121647177 P2RX4 -0.59 -7.32 -0.41 2.92e-12 Gut microbiome composition (summer); CESC cis rs921968 0.528 rs35695178 chr2:219589164 C/T cg02176678 chr2:219576539 TTLL4 -0.43 -7.63 -0.42 4.22e-13 Mean corpuscular hemoglobin concentration; CESC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg14703610 chr5:56206110 C5orf35 0.47 6.14 0.35 3.06e-9 Breast cancer;Breast cancer (early onset); CESC cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg00409905 chr10:38381863 ZNF37A 0.43 5.51 0.32 8.69e-8 Extrinsic epigenetic age acceleration; CESC cis rs6912958 0.967 rs6914299 chr6:88149176 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -7.84 -0.43 1.12e-13 Monocyte percentage of white cells; CESC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg10351095 chr21:47802916 PCNT -0.49 -5.97 -0.34 7.5e-9 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18110965 chr2:62423083 B3GNT2 0.61 6.76 0.38 8.65e-11 Gut microbiome composition (summer); CESC cis rs2124969 0.562 rs4665164 chr2:161070078 T/G cg03641300 chr2:160917029 PLA2R1 -0.38 -5.31 -0.31 2.34e-7 Waist circumference adjusted for body mass index; CESC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg18225595 chr11:63971243 STIP1 -0.66 -9.05 -0.49 3.16e-17 Platelet count; CESC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg18350739 chr11:68623251 NA -0.48 -7.02 -0.4 1.91e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13064411 0.696 rs36054418 chr3:113204762 G/T cg18753928 chr3:113234510 CCDC52 -0.52 -6.24 -0.36 1.73e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg05890377 chr2:74357713 NA 0.78 8.99 0.48 4.66e-17 Gestational age at birth (maternal effect); CESC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg11905131 chr22:24372483 LOC391322 0.75 10.61 0.55 3.9e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg16447950 chr5:562315 NA -0.65 -6.74 -0.38 9.66e-11 Lung disease severity in cystic fibrosis; CESC cis rs73206853 0.841 rs11065631 chr12:110778383 A/G cg12870014 chr12:110450643 ANKRD13A 0.65 5.1 0.3 6.59e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7927771 0.524 rs11039431 chr11:47872012 G/T cg18512352 chr11:47633146 NA 0.35 5.38 0.31 1.6e-7 Subjective well-being; CESC cis rs9815354 0.767 rs73071238 chr3:41992243 A/G cg03022575 chr3:42003672 ULK4 0.67 5.88 0.34 1.23e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.51 7.5 0.42 9.53e-13 Total body bone mineral density; CESC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.55 0.47 9.8e-16 Menopause (age at onset); CESC cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.14 -0.45 1.55e-14 Personality dimensions; CESC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.17e-9 Menopause (age at onset); CESC cis rs6121246 0.954 rs73241710 chr20:30424956 G/A cg13852791 chr20:30311386 BCL2L1 0.75 7.46 0.42 1.27e-12 Mean corpuscular hemoglobin; CESC cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg03146154 chr1:46216737 IPP -0.44 -5.61 -0.33 5.09e-8 High light scatter reticulocyte count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07031794 chr2:26568949 SELI;GPR113 0.5 6.34 0.36 1e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg18225595 chr11:63971243 STIP1 0.53 5.44 0.32 1.23e-7 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03348573 chr5:133304316 C5orf15 0.53 6.05 0.35 5.02e-9 Gut microbiome composition (summer); CESC cis rs2952156 0.876 rs2313171 chr17:37833842 T/C cg00129232 chr17:37814104 STARD3 -0.73 -10.32 -0.54 3.36e-21 Asthma; CESC cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg14393609 chr7:65229607 NA -0.4 -5.3 -0.31 2.38e-7 Aortic root size; CESC cis rs11031096 0.502 rs4910875 chr11:4047855 C/G cg18678763 chr11:4115507 RRM1 -0.46 -6.15 -0.35 2.81e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs684232 0.666 rs423887 chr17:593600 A/G cg15660573 chr17:549704 VPS53 -0.64 -7.98 -0.44 4.3e-14 Prostate cancer; CESC cis rs75477785 0.590 rs4844940 chr1:210190104 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.91 6.36 0.36 8.83e-10 Cleft lip with or without cleft palate; CESC cis rs763014 0.898 rs8050792 chr16:656033 T/C cg00908189 chr16:619842 PIGQ 0.62 8.66 0.47 4.86e-16 Height; CESC cis rs892961 0.899 rs312911 chr17:75414585 A/C cg05865280 chr17:75406074 SEPT9 0.65 13.79 0.65 5.73e-33 Airflow obstruction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20809690 chr4:2757764 TNIP2 0.61 7.54 0.42 7.3e-13 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.87 0.62 9.16e-30 Colonoscopy-negative controls vs population controls; CESC cis rs12410462 0.581 rs77430808 chr1:227540880 C/T cg10327440 chr1:227177885 CDC42BPA -0.67 -5.56 -0.32 6.69e-8 Major depressive disorder; CESC cis rs4919694 0.572 rs12243903 chr10:104906992 T/C cg04362960 chr10:104952993 NT5C2 0.63 6.25 0.36 1.66e-9 Arsenic metabolism; CESC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.92 -11.61 -0.58 1.81e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.85 -12.98 -0.62 3.74e-30 Systemic lupus erythematosus; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07241146 chr10:134145514 LRRC27 0.44 6.12 0.35 3.38e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7224668 0.647 rs9898133 chr17:79249997 C/T cg05632623 chr17:78450055 NPTX1 -0.29 -5.1 -0.3 6.46e-7 IgG glycosylation; CESC cis rs10088262 0.629 rs7827665 chr8:124804190 G/A cg15047889 chr8:124780837 FAM91A1 -0.53 -6.72 -0.38 1.12e-10 Pancreatic cancer; CESC cis rs11673344 0.528 rs573294 chr19:37410162 C/T cg27390819 chr19:37464633 NA -0.34 -5.12 -0.3 5.92e-7 Obesity-related traits; CESC cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg25517755 chr10:38738941 LOC399744 -0.49 -6.37 -0.36 8.45e-10 Extrinsic epigenetic age acceleration; CESC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg24829409 chr8:58192753 C8orf71 -0.59 -7.36 -0.41 2.39e-12 Developmental language disorder (linguistic errors); CESC cis rs425277 0.959 rs77665022 chr1:2065958 C/T cg04315214 chr1:2043799 PRKCZ -0.41 -5.84 -0.34 1.56e-8 Height; CESC cis rs12765878 1.000 rs11191865 chr10:105672842 G/A cg11005552 chr10:105648138 OBFC1 0.37 5.27 0.31 2.84e-7 Coronary artery disease; CESC cis rs9300255 0.722 rs12298826 chr12:123829028 A/G cg00376283 chr12:123451042 ABCB9 -0.58 -6.75 -0.38 9.12e-11 Neutrophil percentage of white cells; CESC cis rs7254192 0.625 rs736625 chr19:41265201 C/T cg24958765 chr19:41283667 RAB4B -0.4 -5.05 -0.3 8.22e-7 Post bronchodilator FEV1; CESC cis rs959260 1.000 rs2053157 chr17:73378595 A/T cg20590849 chr17:73267439 MIF4GD -0.59 -6.78 -0.38 7.58e-11 Systemic lupus erythematosus; CESC cis rs6456156 0.586 rs12198816 chr6:167483546 G/A cg23791538 chr6:167370224 RNASET2 -0.54 -6.94 -0.39 3.07e-11 Primary biliary cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22685446 chr4:142142014 ZNF330 0.62 7.37 0.41 2.12e-12 Gut microbiome composition (summer); CESC cis rs10752881 1.000 rs10911185 chr1:182971747 G/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.37 0.63 1.69e-31 Colorectal cancer; CESC cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg03433033 chr1:76189801 ACADM 0.61 6.28 0.36 1.39e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg08888203 chr3:10149979 C3orf24 0.55 7.2 0.4 6.16e-12 Alzheimer's disease; CESC cis rs4819052 0.635 rs2838808 chr21:46621106 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.06 0.35 4.54e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg00166722 chr3:10149974 C3orf24 0.48 5.35 0.31 1.93e-7 Alzheimer's disease; CESC cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg09035930 chr12:129282057 SLC15A4 0.67 9.06 0.49 2.87e-17 Systemic lupus erythematosus; CESC cis rs3096299 0.967 rs753852 chr16:89446419 G/A cg02187348 chr16:89574699 SPG7 0.56 7.25 0.41 4.68e-12 Multiple myeloma (IgH translocation); CESC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.16 -0.63 8.66e-31 Developmental language disorder (linguistic errors); CESC cis rs2933343 0.700 rs2630257 chr3:128644015 T/C cg25356066 chr3:128598488 ACAD9 0.6 8.44 0.46 2.09e-15 IgG glycosylation; CESC cis rs75477785 0.590 rs11119373 chr1:210122652 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.94 6.76 0.38 8.97e-11 Cleft lip with or without cleft palate; CESC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg04944784 chr2:26401820 FAM59B -0.97 -11.29 -0.57 2.22e-24 Gut microbiome composition (summer); CESC trans rs875971 0.540 rs35510581 chr7:65578777 G/A cg26939375 chr7:64535504 NA -0.62 -8.29 -0.45 5.85e-15 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04238871 chr10:126431886 FAM53B -0.44 -6.68 -0.38 1.4e-10 Gambling; CESC cis rs10504229 0.679 rs12375445 chr8:58040082 A/G cg24829409 chr8:58192753 C8orf71 -0.5 -6.25 -0.36 1.61e-9 Developmental language disorder (linguistic errors); CESC cis rs9814567 0.762 rs13070654 chr3:134219348 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.44 5.68 0.33 3.53e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.5 -5.76 -0.33 2.29e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs208520 0.690 rs1563929 chr6:66702108 G/A cg07460842 chr6:66804631 NA 0.97 12.72 0.62 2.88e-29 Exhaled nitric oxide output; CESC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg24829409 chr8:58192753 C8orf71 -0.75 -9.9 -0.52 7.27e-20 Developmental language disorder (linguistic errors); CESC cis rs2839186 0.807 rs2032226 chr21:47680352 G/A cg10351095 chr21:47802916 PCNT -0.51 -6.92 -0.39 3.35e-11 Testicular germ cell tumor; CESC cis rs921968 0.591 rs3731877 chr2:219602499 G/C cg02176678 chr2:219576539 TTLL4 -0.46 -8.24 -0.45 8.18e-15 Mean corpuscular hemoglobin concentration; CESC cis rs1050631 0.564 rs1785934 chr18:33718326 A/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.51e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg07701084 chr6:150067640 NUP43 -0.44 -5.97 -0.34 7.45e-9 Lung cancer; CESC cis rs2066819 0.786 rs111580405 chr12:56739557 A/G cg26714650 chr12:56694279 CS -1.39 -9.17 -0.49 1.33e-17 Psoriasis vulgaris; CESC cis rs9457247 0.565 rs2038580 chr6:167456490 A/T cg23791538 chr6:167370224 RNASET2 -0.54 -7.12 -0.4 9.98e-12 Crohn's disease; CESC cis rs793571 0.543 rs4775087 chr15:58974904 T/C cg05156742 chr15:59063176 FAM63B 0.59 8.05 0.44 2.82e-14 Schizophrenia; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg02099053 chr1:110880516 RBM15 0.43 6.23 0.36 1.79e-9 Positive affect; CESC cis rs684232 0.666 rs1227028 chr17:573298 G/A cg12384639 chr17:618140 VPS53 0.4 5.15 0.3 5.02e-7 Prostate cancer; CESC cis rs6088580 0.634 rs6059887 chr20:33101102 C/G cg06115741 chr20:33292138 TP53INP2 0.45 5.8 0.34 1.88e-8 Glomerular filtration rate (creatinine); CESC cis rs10493773 0.775 rs11161662 chr1:86185040 A/G cg17807903 chr1:86174739 ZNHIT6 -0.39 -5.41 -0.32 1.39e-7 Urate levels in overweight individuals; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg07049977 chr2:37458536 CEBPZ;C2orf56 -0.45 -6.52 -0.37 3.49e-10 Breast cancer; CESC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.66 -0.33 3.97e-8 Total body bone mineral density; CESC cis rs6541297 0.699 rs4846916 chr1:230296492 G/A cg20703242 chr1:230279135 GALNT2 0.61 6.92 0.39 3.31e-11 Coronary artery disease; CESC cis rs11122272 0.766 rs2024879 chr1:231528638 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 10.88 0.56 4.85e-23 Personality dimensions; CESC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg10074409 chr1:209979377 IRF6 0.34 5.12 0.3 5.83e-7 Cleft lip with or without cleft palate; CESC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg08392591 chr16:89556376 ANKRD11 0.55 7.48 0.42 1.11e-12 Multiple myeloma (IgH translocation); CESC cis rs7259376 0.936 rs58170323 chr19:22539115 T/C cg02657401 chr19:22469223 NA -0.25 -5.05 -0.3 8.16e-7 Menopause (age at onset); CESC cis rs10504229 0.516 rs4060631 chr8:57990757 G/A cg22535103 chr8:58192502 C8orf71 -0.48 -5.89 -0.34 1.16e-8 Developmental language disorder (linguistic errors); CESC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.65 -0.33 4.05e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs8077577 1.000 rs2015336 chr17:18073610 A/G cg16794390 chr17:18148240 FLII 0.42 5.58 0.32 5.98e-8 Obesity-related traits; CESC cis rs6963495 0.818 rs55691539 chr7:105165774 T/C cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs3020736 0.500 rs5996111 chr22:42493902 C/T cg15557168 chr22:42548783 NA 0.44 6.1 0.35 3.82e-9 Autism spectrum disorder or schizophrenia; CESC cis rs727505 0.954 rs1568883 chr7:124710761 G/A cg23710748 chr7:124431027 NA -0.38 -5.98 -0.34 7.1e-9 Lewy body disease; CESC cis rs853679 0.882 rs4713139 chr6:28092685 C/T cg23372001 chr6:27791640 HIST1H4J 0.56 5.05 0.3 8.2e-7 Depression; CESC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg17372223 chr3:52568218 NT5DC2 0.42 6.29 0.36 1.32e-9 Bipolar disorder; CESC cis rs921968 0.541 rs6710383 chr2:219359685 T/G cg02176678 chr2:219576539 TTLL4 0.5 8.98 0.48 5.22e-17 Mean corpuscular hemoglobin concentration; CESC cis rs611744 0.647 rs4735053 chr8:109260776 A/G cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.65e-8 Dupuytren's disease; CESC cis rs9902453 0.619 rs1038088 chr17:28074563 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.22 -0.53 6.81e-21 Coffee consumption (cups per day); CESC cis rs7937682 0.575 rs34695265 chr11:111719128 T/C cg09085632 chr11:111637200 PPP2R1B 0.89 11.46 0.58 5.91e-25 Primary sclerosing cholangitis; CESC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg02951883 chr7:2050386 MAD1L1 -0.47 -6.2 -0.36 2.19e-9 Bipolar disorder and schizophrenia; CESC cis rs9916302 0.904 rs9905432 chr17:37555918 C/A cg00129232 chr17:37814104 STARD3 0.56 7.35 0.41 2.4e-12 Glomerular filtration rate (creatinine); CESC cis rs3736485 0.966 rs4775960 chr15:51891698 C/G cg08986416 chr15:51914746 DMXL2 -0.4 -5.07 -0.3 7.33e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2011503 0.941 rs10422893 chr19:19372185 G/C cg11584989 chr19:19387371 SF4 0.53 6.32 0.36 1.09e-9 Bipolar disorder; CESC cis rs7208859 0.573 rs8078182 chr17:29149664 C/T cg13385521 chr17:29058706 SUZ12P 0.53 5.04 0.3 8.47e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs17799476 0.938 rs56033319 chr2:46358886 G/C cg12428440 chr2:46370979 PRKCE 0.53 5.23 0.31 3.48e-7 Hemoglobin concentration;Hematocrit; CESC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg13206674 chr6:150067644 NUP43 0.41 5.53 0.32 7.84e-8 Lung cancer; CESC cis rs7264396 0.563 rs2425146 chr20:34355268 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.68 7.4 0.41 1.83e-12 Total cholesterol levels; CESC cis rs9875589 0.509 rs2607757 chr3:14081948 A/G cg19554555 chr3:13937349 NA 0.46 6.2 0.36 2.15e-9 Ovarian reserve; CESC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg11764359 chr7:65958608 NA -0.78 -11.43 -0.57 7.35e-25 Aortic root size; CESC cis rs4595586 0.545 rs4768505 chr12:39380338 C/A cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg11644478 chr21:40555479 PSMG1 -0.99 -16.65 -0.72 4.27e-43 Cognitive function; CESC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg18190219 chr22:46762943 CELSR1 -0.6 -6.73 -0.38 1.07e-10 LDL cholesterol;Cholesterol, total; CESC cis rs2732480 0.577 rs2732448 chr12:48730600 T/C cg24011408 chr12:48396354 COL2A1 0.43 5.97 0.34 7.7e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6499255 0.951 rs7196943 chr16:69592449 T/A cg15192750 chr16:69999425 NA 0.54 6.3 0.36 1.24e-9 IgE levels; CESC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg25036284 chr2:26402008 FAM59B 0.88 9.99 0.52 3.79e-20 Gut microbiome composition (summer); CESC cis rs7474896 0.583 rs10740950 chr10:38003496 C/T cg25427524 chr10:38739819 LOC399744 -0.47 -5.51 -0.32 8.62e-8 Obesity (extreme); CESC cis rs2652834 1.000 rs2729833 chr15:63397044 G/A cg05507819 chr15:63340323 TPM1 0.54 5.03 0.3 8.84e-7 HDL cholesterol; CESC cis rs2425143 0.512 rs11699653 chr20:34622916 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.54 6.65 0.38 1.71e-10 Blood protein levels; CESC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg08027265 chr7:2291960 NA -0.34 -5.18 -0.3 4.33e-7 Bipolar disorder and schizophrenia; CESC cis rs9300255 0.722 rs12304248 chr12:123810425 C/T cg00376283 chr12:123451042 ABCB9 -0.59 -6.87 -0.39 4.61e-11 Neutrophil percentage of white cells; CESC trans rs6952808 0.789 rs35729895 chr7:1885069 C/T cg24247370 chr13:99142703 STK24 -0.41 -6.15 -0.35 2.78e-9 Bipolar disorder and schizophrenia; CESC cis rs1707322 0.682 rs28508523 chr1:46189625 G/A cg05343316 chr1:45956843 TESK2 0.48 6.09 0.35 3.85e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 6.88 0.39 4.32e-11 Melanoma; CESC cis rs6088590 0.965 rs910869 chr20:33292777 C/T cg06115741 chr20:33292138 TP53INP2 0.61 7.4 0.41 1.83e-12 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15017043 chr7:100174944 LRCH4 0.48 6.54 0.37 3.14e-10 Fibrinogen levels; CESC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.54 -0.37 3.12e-10 Depression; CESC cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg24110177 chr3:50126178 RBM5 0.52 7.23 0.41 5.15e-12 Intelligence (multi-trait analysis); CESC cis rs2070488 0.965 rs2300668 chr3:38540541 A/G cg24069376 chr3:38537580 EXOG -0.46 -8.63 -0.47 5.78e-16 Electrocardiographic conduction measures; CESC cis rs3105593 1.000 rs3109880 chr15:50837812 G/A cg08437265 chr15:50716283 USP8 0.43 5.62 0.33 4.77e-8 QT interval; CESC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg16743903 chr16:89593216 SPG7 -0.43 -5.47 -0.32 1.05e-7 Multiple myeloma (IgH translocation); CESC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg20243544 chr17:37824526 PNMT -0.44 -5.29 -0.31 2.51e-7 Glomerular filtration rate (creatinine); CESC cis rs7523050 0.643 rs17621851 chr1:109400835 C/T cg08274380 chr1:109419600 GPSM2 0.85 5.61 0.33 5.08e-8 Fat distribution (HIV); CESC trans rs11039798 0.588 rs7116858 chr11:48543920 C/A cg15704280 chr7:45808275 SEPT13 0.66 6.73 0.38 1.05e-10 Axial length; CESC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg06456125 chr7:65229604 NA 0.45 5.94 0.34 8.73e-9 Calcium levels; CESC cis rs1050631 0.564 rs1789549 chr18:33722425 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.51e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs2439831 0.702 rs16977724 chr15:44151299 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.66 5.66 0.33 3.88e-8 Lung cancer in ever smokers; CESC cis rs8180040 0.676 rs13098228 chr3:47138253 A/G cg27129171 chr3:47204927 SETD2 0.73 11.38 0.57 1.09e-24 Colorectal cancer; CESC cis rs17376456 0.877 rs34595581 chr5:93369422 G/A cg25358565 chr5:93447407 FAM172A 1.11 10.67 0.55 2.44e-22 Diabetic retinopathy; CESC cis rs1348850 0.626 rs1901825 chr2:178225331 A/T cg23306229 chr2:178417860 TTC30B 0.54 6.91 0.39 3.51e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7216064 0.953 rs11079705 chr17:65835452 A/T cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.73e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9611519 0.603 rs9607764 chr22:41411804 G/C cg03806693 chr22:41940476 POLR3H -0.51 -6.04 -0.35 5.18e-9 Neuroticism; CESC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg12718519 chr1:2058417 PRKCZ -0.25 -5.36 -0.31 1.81e-7 Height; CESC cis rs3796352 1.000 rs71617204 chr3:53042951 G/A cg12962167 chr3:53033115 SFMBT1 0.65 5.17 0.3 4.52e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC cis rs6541297 0.941 rs2180078 chr1:230280513 T/C cg20703242 chr1:230279135 GALNT2 0.73 11.12 0.56 8.07e-24 Coronary artery disease; CESC cis rs9863 0.861 rs7973683 chr12:124449223 C/A cg17562584 chr12:124393655 DNAH10 0.32 5.55 0.32 6.96e-8 White blood cell count; CESC cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg13902645 chr11:5959945 NA -0.67 -8.06 -0.44 2.63e-14 DNA methylation (variation); CESC cis rs2576037 0.583 rs9960463 chr18:44522808 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -6.78 -0.38 7.97e-11 Personality dimensions; CESC cis rs11252926 0.523 rs816596 chr10:548004 C/T cg18196295 chr10:418757 DIP2C 0.5 6.78 0.38 7.76e-11 Psychosis in Alzheimer's disease; CESC cis rs7772486 0.790 rs9390365 chr6:146235626 A/G cg23711669 chr6:146136114 FBXO30 -0.94 -13.73 -0.64 9.31e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs13223928 0.516 rs11763949 chr7:3150279 A/C cg19214707 chr7:3157722 NA -0.44 -6.05 -0.35 4.79e-9 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs56116382 0.605 rs12715435 chr3:49338992 G/A cg00383909 chr3:49044727 WDR6 0.58 5.32 0.31 2.26e-7 Intelligence (multi-trait analysis);High light scatter reticulocyte count; CESC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg03709012 chr19:19516395 GATAD2A -0.96 -14.11 -0.66 4.09e-34 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01099470 chr2:131103656 IMP4 0.46 6.0 0.35 6.33e-9 Fibrinogen levels; CESC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg25767906 chr1:53392781 SCP2 0.41 5.64 0.33 4.36e-8 Monocyte count; CESC cis rs7296418 0.580 rs78455769 chr12:123856443 G/A cg05973401 chr12:123451056 ABCB9 0.43 5.49 0.32 9.54e-8 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13179130 chr1:24070416 TCEB3 0.65 6.91 0.39 3.5e-11 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg22535103 chr8:58192502 C8orf71 -0.81 -9.14 -0.49 1.65e-17 Developmental language disorder (linguistic errors); CESC cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg00701064 chr4:6280414 WFS1 0.7 12.4 0.61 3.83e-28 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs561341 1.000 rs1557731 chr17:30321567 T/G cg00745463 chr17:30367425 LRRC37B -0.68 -6.81 -0.39 6.34e-11 Hip circumference adjusted for BMI; CESC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg27266027 chr21:40555129 PSMG1 0.49 6.01 0.35 6.02e-9 Cognitive function; CESC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg03452623 chr4:187889614 NA -0.88 -16.16 -0.7 2.39e-41 Lobe attachment (rater-scored or self-reported); CESC trans rs9929218 1.000 rs12446407 chr16:68804068 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.21 -0.45 9.51e-15 Colorectal cancer; CESC cis rs9399137 0.507 rs13214669 chr6:135299959 T/C cg24558204 chr6:135376177 HBS1L 0.7 9.49 0.5 1.39e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs12410462 1.000 rs12410243 chr1:227669474 A/G cg23173402 chr1:227635558 NA 0.62 6.29 0.36 1.31e-9 Major depressive disorder; CESC cis rs12142240 0.698 rs56284503 chr1:46847127 C/G cg00530320 chr1:46809349 NSUN4 0.6 8.3 0.45 5.19e-15 Menopause (age at onset); CESC cis rs2625529 0.824 rs4776581 chr15:72207071 G/A cg16672083 chr15:72433130 SENP8 -0.39 -5.1 -0.3 6.54e-7 Red blood cell count; CESC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg14393609 chr7:65229607 NA -0.47 -6.3 -0.36 1.24e-9 Aortic root size; CESC cis rs6426558 0.537 rs488104 chr1:227300277 G/A cg10327440 chr1:227177885 CDC42BPA 0.47 5.84 0.34 1.48e-8 Neutrophil percentage of white cells; CESC cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg06544989 chr22:39130855 UNC84B 0.5 8.55 0.46 1.02e-15 Menopause (age at onset); CESC cis rs60843830 1.000 rs7605824 chr2:280819 A/G cg25945732 chr2:264204 ACP1;SH3YL1 -0.89 -12.02 -0.59 7.41e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs734999 0.588 rs2985859 chr1:2532416 T/C cg18854424 chr1:2615690 NA -0.28 -5.34 -0.31 1.99e-7 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10345337 chr14:65569751 MAX -0.6 -7.21 -0.4 5.82e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01796143 chr1:236687575 LGALS8 0.55 6.05 0.35 4.97e-9 Gut microbiome composition (summer); CESC trans rs694739 0.628 rs508168 chr11:64135435 G/A cg01888411 chr11:34378293 ABTB2 0.4 6.01 0.35 6e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC trans rs6991952 0.845 rs7822766 chr8:25742279 A/T cg06620762 chr15:76136437 UBE2Q2 -0.49 -6.16 -0.35 2.68e-9 Inguinal hernia; CESC cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2635047 0.601 rs2635052 chr18:44650607 C/G cg19077165 chr18:44547161 KATNAL2 -0.37 -5.04 -0.3 8.63e-7 Educational attainment; CESC cis rs6088590 0.965 rs6087619 chr20:33288511 C/G cg08999081 chr20:33150536 PIGU 0.59 9.11 0.49 2.13e-17 Coronary artery disease; CESC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.61e-7 Life satisfaction; CESC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg24733560 chr20:60626293 TAF4 0.46 6.62 0.38 1.97e-10 Body mass index; CESC cis rs28374715 0.562 rs8036686 chr15:41550333 C/T cg18705301 chr15:41695430 NDUFAF1 -0.52 -7.4 -0.41 1.77e-12 Ulcerative colitis; CESC cis rs17401966 0.867 rs61775872 chr1:10279308 T/C cg15208524 chr1:10270712 KIF1B 0.42 5.45 0.32 1.17e-7 Hepatocellular carcinoma; CESC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.54 0.54 6.46e-22 Platelet count; CESC trans rs7178375 0.678 rs34678577 chr15:31177465 A/C cg04373760 chr16:53404718 NA 0.49 6.42 0.37 6.37e-10 Hypertriglyceridemia; CESC cis rs7605827 0.897 rs4459705 chr2:15526584 C/T cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs9300255 0.739 rs4759371 chr12:123742563 T/C cg19016782 chr12:123741754 C12orf65 -0.48 -6.9 -0.39 3.71e-11 Neutrophil percentage of white cells; CESC cis rs7103648 0.695 rs11039290 chr11:47572279 G/A cg20307385 chr11:47447363 PSMC3 0.82 11.97 0.59 1.09e-26 Diastolic blood pressure;Systolic blood pressure; CESC cis rs9354308 0.933 rs2802063 chr6:66564148 T/C cg07460842 chr6:66804631 NA 0.67 7.56 0.42 6.71e-13 Metabolite levels; CESC cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg17372223 chr3:52568218 NT5DC2 0.42 6.35 0.36 9.4e-10 Bipolar disorder; CESC cis rs17253792 0.822 rs76472022 chr14:56053660 C/T cg01858014 chr14:56050164 KTN1 -0.97 -7.15 -0.4 8.64e-12 Putamen volume; CESC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg25985355 chr7:65971099 NA 0.33 5.52 0.32 7.94e-8 Aortic root size; CESC trans rs11638815 0.954 rs11635476 chr15:83339500 A/G cg25333056 chr10:135107159 TUBGCP2 -0.46 -6.05 -0.35 4.9e-9 Lipoprotein-associated phospholipase A2 activity change in response to statin therapy; CESC cis rs1881797 0.932 rs4551631 chr1:247667663 C/T cg11166453 chr1:247681781 NA -0.52 -6.86 -0.39 4.86e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.16e-7 Life satisfaction; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15433164 chr3:25824899 NGLY1 0.42 6.08 0.35 4.15e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg10191684 chr8:22423014 SORBS3 -0.45 -6.35 -0.36 9.12e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs3126085 0.736 rs11581433 chr1:152283236 T/C cg03465714 chr1:152285911 FLG 0.5 5.71 0.33 2.96e-8 Atopic dermatitis; CESC cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg13647721 chr17:30228624 UTP6 0.54 5.29 0.31 2.53e-7 Hip circumference adjusted for BMI; CESC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg07936489 chr17:37558343 FBXL20 0.81 11.8 0.59 4.01e-26 Glomerular filtration rate (creatinine); CESC cis rs72781680 0.851 rs72796397 chr2:24178211 T/A cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs3768617 0.811 rs4285667 chr1:182970225 T/A ch.1.3577855R chr1:183094577 LAMC1 0.65 9.01 0.48 4.1e-17 Fuchs's corneal dystrophy; CESC cis rs17253792 0.822 rs79921041 chr14:56090779 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12728516 chr1:155197152 GBAP1 -0.6 -7.38 -0.41 2e-12 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25533220 chr19:2328480 SPPL2B;LSM7 0.5 6.46 0.37 4.89e-10 Gut microbiota (bacterial taxa); CESC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg00310523 chr12:86230176 RASSF9 0.35 5.45 0.32 1.14e-7 Major depressive disorder; CESC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg13206674 chr6:150067644 NUP43 0.46 6.52 0.37 3.5e-10 Lung cancer; CESC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg27286337 chr10:134555280 INPP5A 0.68 7.64 0.42 4.05e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.65 -0.51 4.31e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9914988 0.887 rs4795464 chr17:27146497 G/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg01988459 chr11:68622903 NA -0.46 -6.57 -0.37 2.64e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7086627 0.515 rs7078254 chr10:82212193 C/T cg00277334 chr10:82204260 NA -0.91 -15.67 -0.69 1.25e-39 Post bronchodilator FEV1; CESC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.64 -0.51 4.86e-19 Alzheimer's disease; CESC cis rs6493487 0.512 rs17521789 chr15:51271177 G/A cg02338191 chr15:51200825 AP4E1 0.61 5.58 0.32 6.04e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4308124 0.708 rs67816163 chr2:111963310 A/G cg04571233 chr2:111982156 NA -0.64 -7.06 -0.4 1.47e-11 Vitiligo; CESC cis rs425277 1.000 rs74877653 chr1:2065949 C/T cg24578937 chr1:2090814 PRKCZ 0.53 8.95 0.48 6.35e-17 Height; CESC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg06456125 chr7:65229604 NA -0.4 -5.15 -0.3 5.11e-7 Aortic root size; CESC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg22535103 chr8:58192502 C8orf71 -0.71 -8.43 -0.46 2.21e-15 Developmental language disorder (linguistic errors); CESC trans rs116095464 0.558 rs55833259 chr5:286728 G/A cg00938859 chr5:1591904 SDHAP3 0.72 6.62 0.38 2.04e-10 Breast cancer; CESC cis rs8018808 0.935 rs11159262 chr14:77928735 A/G cg20045696 chr14:77926864 AHSA1 0.43 5.9 0.34 1.13e-8 Myeloid white cell count; CESC cis rs9457247 0.967 rs1794696 chr6:167396174 T/C cg25258033 chr6:167368657 RNASET2 0.38 5.79 0.33 2.01e-8 Crohn's disease; CESC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.35 0.81 6.51e-63 Prudent dietary pattern; CESC cis rs7799006 0.929 rs35629140 chr7:2257171 G/C cg08027265 chr7:2291960 NA -0.5 -7.67 -0.43 3.19e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4700695 0.545 rs253275 chr5:65509809 A/G cg21114390 chr5:65439923 SFRS12 -0.5 -5.89 -0.34 1.15e-8 Facial morphology (factor 19); CESC cis rs4604732 0.536 rs12049066 chr1:247642655 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.41 5.41 0.32 1.4e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2228479 0.850 rs57267516 chr16:89903552 G/A cg06558623 chr16:89946397 TCF25 0.98 7.35 0.41 2.45e-12 Skin colour saturation; CESC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg21724239 chr8:58056113 NA 0.58 5.16 0.3 4.75e-7 Developmental language disorder (linguistic errors); CESC cis rs9894429 0.646 rs9905639 chr17:79614154 A/G cg21984481 chr17:79567631 NPLOC4 -0.36 -5.6 -0.33 5.23e-8 Eye color traits; CESC cis rs2011503 0.941 rs2315023 chr19:19413393 C/T cg11584989 chr19:19387371 SF4 0.64 7.68 0.43 3.04e-13 Bipolar disorder; CESC cis rs10887741 0.646 rs1358864 chr10:89426630 A/C cg13926569 chr10:89418898 PAPSS2 0.48 7.39 0.41 1.97e-12 Exercise (leisure time); CESC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg24531977 chr5:56204891 C5orf35 -0.88 -11.06 -0.56 1.21e-23 Initial pursuit acceleration; CESC cis rs1564271 0.553 rs9334138 chr10:26978929 G/A cg13837822 chr10:26931731 LOC731789 0.45 6.91 0.39 3.55e-11 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CESC cis rs2204008 0.775 rs11514370 chr12:38305566 G/A cg26384229 chr12:38710491 ALG10B 0.66 9.71 0.51 2.92e-19 Bladder cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00613399 chr15:89010912 MRPL46;MRPS11 -0.43 -6.0 -0.35 6.63e-9 Gambling; CESC cis rs963731 0.649 rs2123876 chr2:39255873 C/G cg04010122 chr2:39346883 SOS1 -0.74 -5.09 -0.3 6.9e-7 Corticobasal degeneration; CESC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg18404041 chr3:52824283 ITIH1 -0.37 -6.32 -0.36 1.12e-9 Bipolar disorder; CESC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.16 0.81 2.75e-62 Prudent dietary pattern; CESC cis rs2415984 0.600 rs2084823 chr14:46966454 C/G cg14871534 chr14:47121158 RPL10L 0.35 5.32 0.31 2.19e-7 Number of children ever born; CESC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg21984481 chr17:79567631 NPLOC4 -0.49 -8.04 -0.44 2.97e-14 Eye color traits; CESC cis rs9486715 1.000 rs11153085 chr6:97066355 A/T cg18709589 chr6:96969512 KIAA0776 -0.46 -6.48 -0.37 4.56e-10 Headache; CESC cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg23711669 chr6:146136114 FBXO30 1.03 16.03 0.7 6.76e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs7193541 0.682 rs28681530 chr16:74682496 C/T cg05580060 chr16:74700937 RFWD3 -0.49 -6.3 -0.36 1.27e-9 Multiple myeloma; CESC cis rs2599510 0.703 rs58852184 chr2:32729763 A/T cg02381751 chr2:32503542 YIPF4 0.5 6.32 0.36 1.12e-9 Interleukin-18 levels; CESC cis rs6547741 1.000 rs4666007 chr2:27856495 T/C cg21248554 chr2:27665150 KRTCAP3 0.25 5.3 0.31 2.42e-7 Oral cavity cancer; CESC cis rs13102973 1.000 rs13112665 chr4:135898581 C/A cg14419869 chr4:135874104 NA 0.33 5.1 0.3 6.62e-7 Subjective well-being; CESC cis rs2228479 0.850 rs11646766 chr16:89838578 A/T cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.76 9.6 0.51 6.23e-19 Age-related macular degeneration (geographic atrophy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01832569 chr1:171711313 VAMP4 0.51 6.01 0.35 6e-9 Gut microbiome composition (summer); CESC cis rs17376456 0.877 rs10072592 chr5:93405989 C/G cg21475434 chr5:93447410 FAM172A 0.87 7.47 0.42 1.17e-12 Diabetic retinopathy; CESC cis rs56046484 0.956 rs35885781 chr15:85591083 A/T cg08123816 chr15:85640762 PDE8A -0.5 -6.21 -0.36 2.05e-9 Testicular germ cell tumor; CESC cis rs9581857 0.556 rs9579085 chr13:28041039 G/A cg01674679 chr13:27998804 GTF3A -0.56 -5.93 -0.34 9.2e-9 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs637571 0.544 rs56239996 chr11:65730003 A/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 10.26 0.53 5.13e-21 Eosinophil percentage of white cells; CESC cis rs3767633 0.925 rs4657103 chr1:161740483 G/T cg09175582 chr1:161736000 ATF6 0.8 6.58 0.37 2.49e-10 IgG glycosylation; CESC cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg19193384 chr17:30244184 NA -0.7 -6.62 -0.38 2e-10 Hip circumference adjusted for BMI; CESC cis rs2404602 0.622 rs11632365 chr15:77139080 G/A cg00316803 chr15:76480434 C15orf27 0.43 5.76 0.33 2.34e-8 Blood metabolite levels; CESC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.66 0.43 3.49e-13 Prudent dietary pattern; CESC cis rs4523957 0.757 rs216208 chr17:2195146 T/A cg16513277 chr17:2031491 SMG6 0.57 7.49 0.42 9.97e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6748734 1.000 rs11893118 chr2:241828308 C/G cg04034577 chr2:241836375 C2orf54 -0.52 -9.33 -0.5 4.44e-18 Urinary metabolites; CESC cis rs9682041 0.696 rs16855034 chr3:170097842 C/G cg11886554 chr3:170076028 SKIL 0.7 6.5 0.37 3.93e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs7116495 0.881 rs6592451 chr11:71674937 G/A cg10381502 chr11:71823885 C11orf51 -0.68 -5.67 -0.33 3.64e-8 Severe influenza A (H1N1) infection; CESC cis rs1728785 0.901 rs1631910 chr16:68603335 G/A cg02972257 chr16:68554789 NA -0.59 -6.76 -0.38 8.82e-11 Ulcerative colitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21989094 chr19:39421295 MRPS12;SARS2 0.52 6.66 0.38 1.56e-10 Gut microbiota (bacterial taxa); CESC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg20243544 chr17:37824526 PNMT -0.45 -5.53 -0.32 7.69e-8 Glomerular filtration rate (creatinine); CESC cis rs2295359 0.892 rs2064689 chr1:67653010 G/A cg03340356 chr1:67600835 NA 0.32 5.21 0.31 3.73e-7 Psoriasis; CESC cis rs12477438 0.765 rs1453564 chr2:99564428 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -8.75 -0.47 2.56e-16 Chronic sinus infection; CESC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg26939375 chr7:64535504 NA 0.66 8.83 0.48 1.42e-16 Calcium levels; CESC trans rs1814175 0.616 rs1851848 chr11:49992254 G/C cg03929089 chr4:120376271 NA -0.91 -15.15 -0.68 9.3e-38 Height; CESC cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg06713675 chr4:122721982 EXOSC9 -0.51 -6.96 -0.39 2.71e-11 Type 2 diabetes; CESC cis rs4969178 0.965 rs3817295 chr17:76394526 T/A cg20026190 chr17:76395443 PGS1 0.49 7.91 0.44 6.98e-14 HDL cholesterol levels; CESC cis rs694739 0.628 rs645078 chr11:64135298 A/C cg23796481 chr11:64053134 BAD;GPR137 0.57 6.71 0.38 1.18e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC trans rs208520 0.955 rs17644076 chr6:67004973 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.77 -8.97 -0.48 5.51e-17 Exhaled nitric oxide output; CESC cis rs727563 0.555 rs5751136 chr22:42075581 T/A cg03806693 chr22:41940476 POLR3H 0.92 10.78 0.55 1.06e-22 Crohn's disease;Inflammatory bowel disease; CESC cis rs9486719 1.000 rs2142653 chr6:96871520 C/A cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs3818285 0.556 rs941864 chr10:111656948 T/C cg00817464 chr10:111662876 XPNPEP1 -0.58 -8.35 -0.46 3.79e-15 Superior crus of antihelix expression; CESC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg22920501 chr2:26401640 FAM59B 0.93 10.89 0.56 4.54e-23 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg23018236 chr17:30244563 NA -0.55 -5.31 -0.31 2.37e-7 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25266135 chr15:77835749 NA 0.58 6.23 0.36 1.82e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1198872 0.526 rs57282335 chr2:10928207 G/A cg15705551 chr2:10952987 PDIA6 0.52 6.14 0.35 2.95e-9 Cardiac Troponin-T levels; CESC cis rs2304069 0.695 rs6866298 chr5:149439588 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.74 9.3 0.5 5.4e-18 HIV-1 control; CESC cis rs74181299 0.591 rs2422441 chr2:65370766 A/G cg05010058 chr2:65284262 CEP68 -0.32 -5.23 -0.31 3.48e-7 Pulse pressure; CESC cis rs4664304 0.764 rs2063440 chr2:160800102 A/C cg03641300 chr2:160917029 PLA2R1 -0.41 -5.46 -0.32 1.1e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg08888203 chr3:10149979 C3orf24 -0.46 -5.67 -0.33 3.68e-8 Alzheimer's disease; CESC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg06221963 chr1:154839813 KCNN3 -0.66 -11.23 -0.57 3.52e-24 Prostate cancer; CESC cis rs6963495 0.674 rs75880756 chr7:105163821 G/C cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs10752881 1.000 rs6701400 chr1:182977197 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Colorectal cancer; CESC cis rs9322193 0.607 rs3798763 chr6:150211100 T/C cg01145232 chr6:150245071 RAET1G 0.5 6.25 0.36 1.66e-9 Lung cancer; CESC cis rs11690935 0.851 rs6433319 chr2:172830953 C/T cg13550731 chr2:172543902 DYNC1I2 -0.72 -10.73 -0.55 1.52e-22 Schizophrenia; CESC cis rs708547 0.874 rs1718868 chr4:57881215 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.56 -5.78 -0.33 2.06e-8 Response to bleomycin (chromatid breaks); CESC cis rs11098499 0.955 rs1511015 chr4:120170473 A/C cg09307838 chr4:120376055 NA 0.86 11.39 0.57 9.73e-25 Corneal astigmatism; CESC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg05025164 chr4:1340916 KIAA1530 0.44 6.02 0.35 5.93e-9 Longevity; CESC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg23281280 chr6:28129359 ZNF389 0.58 8.05 0.44 2.72e-14 Depression; CESC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg18451016 chr1:38461880 NA 0.52 8.13 0.45 1.62e-14 Coronary artery disease; CESC cis rs7680126 0.644 rs4697703 chr4:10107431 A/G cg00071950 chr4:10020882 SLC2A9 -0.68 -8.19 -0.45 1.1e-14 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs9796 0.621 rs58109657 chr15:41471750 A/G cg18705301 chr15:41695430 NDUFAF1 0.46 6.81 0.39 6.54e-11 Menopause (age at onset); CESC cis rs3916 0.911 rs12829722 chr12:121155622 C/T cg21892295 chr12:121157589 UNC119B -0.38 -5.26 -0.31 2.94e-7 Urinary metabolites (H-NMR features); CESC cis rs7615952 0.741 rs13314845 chr3:125644782 C/T cg05084668 chr3:125655381 ALG1L -0.51 -6.1 -0.35 3.68e-9 Blood pressure (smoking interaction); CESC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs752010 0.523 rs10890160 chr1:42120011 A/G cg06885757 chr1:42089581 HIVEP3 0.5 7.95 0.44 5.36e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9549260 0.816 rs964901 chr13:41248698 C/T cg21288729 chr13:41239152 FOXO1 0.66 8.39 0.46 2.93e-15 Red blood cell count; CESC cis rs7000551 0.715 rs34649162 chr8:22314730 T/C cg12081754 chr8:22256438 SLC39A14 0.39 5.04 0.3 8.63e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs926938 0.527 rs360583 chr1:115462743 C/T cg12756093 chr1:115239321 AMPD1 0.45 6.28 0.36 1.41e-9 Autism; CESC cis rs2204008 0.543 rs2387018 chr12:38065638 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.11 0.53 1.5e-20 Bladder cancer; CESC cis rs977987 0.806 rs12448947 chr16:75462954 G/A cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19064601 chr11:68142605 LRP5 0.45 6.26 0.36 1.54e-9 Fibrinogen levels; CESC cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg20476274 chr7:133979776 SLC35B4 0.67 9.79 0.52 1.65e-19 Mean platelet volume; CESC cis rs904251 0.797 rs1776460 chr6:37485484 A/G cg01843034 chr6:37503916 NA -0.28 -5.1 -0.3 6.35e-7 Cognitive performance; CESC cis rs2408955 0.568 rs12099462 chr12:48503104 T/C cg04545296 chr12:48745243 ZNF641 -0.33 -5.59 -0.32 5.62e-8 Glycated hemoglobin levels; CESC cis rs9858542 0.953 rs6779524 chr3:49450449 C/T cg07274523 chr3:49395745 GPX1 0.67 8.36 0.46 3.5e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2531992 0.858 rs2230742 chr16:4016676 C/T cg05927578 chr16:4029543 ADCY9 -0.45 -5.61 -0.33 5.03e-8 Waist circumference; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27514286 chr3:183892688 AP2M1 -0.45 -6.04 -0.35 5.26e-9 Fibrinogen levels; CESC cis rs17376456 0.877 rs67066109 chr5:93494101 G/C cg21475434 chr5:93447410 FAM172A 0.88 7.77 0.43 1.71e-13 Diabetic retinopathy; CESC cis rs8050907 0.744 rs11861315 chr16:4518783 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 5.72 0.33 2.93e-8 Obesity-related traits; CESC cis rs2073300 0.609 rs56334525 chr20:23365812 A/G cg16736954 chr20:23401023 NAPB 0.79 5.87 0.34 1.33e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7772486 0.686 rs857875 chr6:145980033 T/G cg05347473 chr6:146136440 FBXO30 -0.55 -7.17 -0.4 7.36e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7618501 1.000 rs7618519 chr3:49772708 A/T cg24308560 chr3:49941425 MST1R 0.5 6.81 0.39 6.38e-11 Intelligence (multi-trait analysis); CESC cis rs12477438 0.501 rs13008171 chr2:99743419 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.85 0.62 1.02e-29 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02500152 chr12:48357316 TMEM106C 0.62 7.48 0.42 1.08e-12 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs1966916 chr17:37425238 T/G cg00129232 chr17:37814104 STARD3 -0.53 -6.89 -0.39 4.12e-11 Glomerular filtration rate (creatinine); CESC cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg04450456 chr4:17643702 FAM184B -0.36 -5.24 -0.31 3.21e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs75804782 0.521 rs56087929 chr2:239455564 G/A cg18131467 chr2:239335373 ASB1 -0.69 -5.57 -0.32 6.11e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs9486715 1.000 rs9486715 chr6:97059769 A/C cg06623918 chr6:96969491 KIAA0776 -0.92 -13.79 -0.65 5.63e-33 Headache; CESC cis rs826838 1.000 rs1684395 chr12:39083161 T/G cg13010199 chr12:38710504 ALG10B -0.41 -5.63 -0.33 4.66e-8 Heart rate; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.97 -0.44 4.77e-14 Electroencephalogram traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27520502 chr17:26684562 POLDIP2;TMEM199 -0.48 -6.33 -0.36 1.06e-9 Fibrinogen levels; CESC cis rs10927875 0.662 rs698893 chr1:16302982 C/T cg22431228 chr1:16359049 CLCNKA -0.51 -9.61 -0.51 5.89e-19 Dilated cardiomyopathy; CESC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg25072359 chr17:41440525 NA 0.47 6.98 0.39 2.42e-11 Menopause (age at onset); CESC cis rs1267303 0.710 rs1535739 chr1:46957719 A/C cg25110126 chr1:46999211 NA -0.53 -5.98 -0.34 7.12e-9 Monobrow; CESC cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg17366294 chr4:99064904 C4orf37 -0.62 -8.5 -0.46 1.43e-15 Colonoscopy-negative controls vs population controls; CESC cis rs72945132 0.825 rs2277273 chr11:70223992 T/C cg00319359 chr11:70116639 PPFIA1 0.72 6.93 0.39 3.17e-11 Coronary artery disease; CESC cis rs17666538 0.710 rs12716640 chr8:645376 A/C cg07234876 chr8:600039 NA 0.78 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs2180341 0.618 rs11154396 chr6:127638911 C/T cg24812749 chr6:127587940 RNF146 0.6 8.09 0.44 2.22e-14 Breast cancer; CESC cis rs2243480 1.000 rs2707844 chr7:66059509 G/A cg13147721 chr7:65941812 NA -0.93 -8.74 -0.47 2.72e-16 Diabetic kidney disease; CESC cis rs116095464 0.558 rs7708515 chr5:234989 C/G cg10591111 chr5:226296 SDHA -0.51 -6.26 -0.36 1.55e-9 Breast cancer; CESC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg18337363 chr3:52569053 NT5DC2 0.29 5.46 0.32 1.08e-7 Electroencephalogram traits; CESC trans rs2727020 0.724 rs4109837 chr11:49372051 A/T cg15704280 chr7:45808275 SEPT13 -0.78 -9.68 -0.51 3.47e-19 Coronary artery disease; CESC cis rs12142240 0.698 rs66483119 chr1:46838389 T/C cg10495392 chr1:46806563 NSUN4 0.58 6.26 0.36 1.54e-9 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24182333 chr10:73610570 PSAP -0.63 -7.37 -0.41 2.17e-12 Gut microbiome composition (summer); CESC cis rs3820928 0.605 rs6748311 chr2:227792530 T/A cg05526886 chr2:227700861 RHBDD1 -0.54 -7.23 -0.41 5.26e-12 Pulmonary function; CESC cis rs11958404 0.932 rs12517979 chr5:157428918 T/C cg05962755 chr5:157440814 NA 0.62 6.61 0.38 2.14e-10 IgG glycosylation; CESC cis rs8141529 0.588 rs10222249 chr22:29257147 A/G cg02153584 chr22:29168773 CCDC117 0.52 6.41 0.37 6.5e-10 Lymphocyte counts; CESC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg24562669 chr7:97807699 LMTK2 0.49 7.17 0.4 7.33e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs6580649 0.941 rs1635529 chr12:48395102 T/G cg24011408 chr12:48396354 COL2A1 0.4 5.1 0.3 6.46e-7 Lung cancer; CESC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 9.59 0.51 6.99e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg06456125 chr7:65229604 NA 0.41 5.31 0.31 2.29e-7 Calcium levels; CESC cis rs412050 0.793 rs238782 chr22:22341992 G/A cg17089214 chr22:22089827 YPEL1 0.56 5.04 0.3 8.7e-7 Attention deficit hyperactivity disorder; CESC cis rs2243480 1.000 rs2707831 chr7:66062511 G/A cg13147721 chr7:65941812 NA -0.93 -8.74 -0.47 2.72e-16 Diabetic kidney disease; CESC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg09877947 chr5:131593287 PDLIM4 0.44 5.37 0.31 1.76e-7 Blood metabolite levels; CESC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg01802117 chr1:53393560 SCP2 -0.4 -5.12 -0.3 5.9e-7 Monocyte count; CESC cis rs6460942 1.000 rs17668923 chr7:12302873 A/T cg20607287 chr7:12443886 VWDE -0.57 -6.53 -0.37 3.32e-10 Coronary artery disease; CESC trans rs7937682 0.855 rs539693 chr11:111477387 A/G cg18187862 chr3:45730750 SACM1L 0.49 6.16 0.35 2.71e-9 Primary sclerosing cholangitis; CESC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.82 0.34 1.67e-8 Menopause (age at onset); CESC cis rs35110281 0.563 rs162371 chr21:44931489 G/T cg21573476 chr21:45109991 RRP1B -0.4 -5.64 -0.33 4.34e-8 Mean corpuscular volume; CESC cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg21918786 chr6:109611834 NA -0.35 -5.03 -0.3 8.9e-7 Reticulocyte fraction of red cells; CESC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg12311346 chr5:56204834 C5orf35 -0.43 -5.46 -0.32 1.08e-7 Coronary artery disease; CESC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg09165964 chr15:75287851 SCAMP5 0.47 6.45 0.37 5.19e-10 Breast cancer; CESC cis rs748404 0.631 rs7167882 chr15:43678663 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.57 8.91 0.48 8.39e-17 Lung cancer; CESC cis rs6788895 1.000 rs74950732 chr3:150482621 C/T cg09723797 chr3:150481914 SIAH2 0.73 5.55 0.32 6.95e-8 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10541813 chr2:85839361 C2orf68 -0.65 -8.09 -0.45 2.11e-14 Gut microbiome composition (summer); CESC cis rs6964587 0.900 rs11984136 chr7:91766953 T/C cg17063962 chr7:91808500 NA 0.57 7.9 0.44 7.64e-14 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09681706 chr7:75703103 NA 0.53 6.94 0.39 2.92e-11 Fibrinogen levels; CESC cis rs3091242 0.933 rs11249250 chr1:25767609 G/A cg27572855 chr1:25598939 RHD 0.44 7.36 0.41 2.34e-12 Erythrocyte sedimentation rate; CESC cis rs17376456 0.825 rs34592268 chr5:93232751 G/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.64 5.49 0.32 9.59e-8 Diabetic retinopathy; CESC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Parkinson's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02723225 chr16:3019192 PAQR4 -0.52 -6.52 -0.37 3.56e-10 Ulcerative colitis; CESC cis rs60871478 0.636 rs61441144 chr7:897784 C/T cg05535760 chr7:792225 HEATR2 -0.74 -7.73 -0.43 2.28e-13 Cerebrospinal P-tau181p levels; CESC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.45 6.18 0.35 2.42e-9 Lymphocyte counts; CESC cis rs9905704 0.918 rs12942969 chr17:56892872 A/T cg12560992 chr17:57184187 TRIM37 0.61 7.21 0.4 5.9e-12 Testicular germ cell tumor; CESC trans rs853679 0.556 rs13200214 chr6:28017250 C/T cg01620082 chr3:125678407 NA -0.83 -6.19 -0.36 2.33e-9 Depression; CESC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg23758822 chr17:41437982 NA 1.01 16.99 0.72 2.66e-44 Menopause (age at onset); CESC cis rs9318086 0.648 rs78881146 chr13:24468704 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.49 6.79 0.38 7.33e-11 Myopia (pathological); CESC cis rs763121 0.853 rs138716 chr22:39146527 C/T cg06544989 chr22:39130855 UNC84B 0.47 8.12 0.45 1.75e-14 Menopause (age at onset); CESC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg23281280 chr6:28129359 ZNF389 0.5 5.49 0.32 9.49e-8 Depression; CESC trans rs11250098 0.574 rs7015168 chr8:10772210 G/C cg15556689 chr8:8085844 FLJ10661 -0.56 -6.63 -0.38 1.87e-10 Morning vs. evening chronotype; CESC cis rs9359856 0.564 rs55722352 chr6:90365853 C/T cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.35 -0.36 9.29e-10 Bipolar disorder; CESC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg21226059 chr5:178986404 RUFY1 0.51 7.84 0.43 1.12e-13 Lung cancer; CESC cis rs3762637 1.000 rs7609972 chr3:122199426 T/G cg24169773 chr3:122142474 KPNA1 -0.54 -6.4 -0.37 6.83e-10 LDL cholesterol levels; CESC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg19163074 chr7:65112434 INTS4L2 0.41 5.28 0.31 2.74e-7 Aortic root size; CESC cis rs2282802 0.685 rs7717576 chr5:139623591 G/A cg26211634 chr5:139558579 C5orf32 0.48 6.88 0.39 4.3e-11 Intelligence (multi-trait analysis); CESC cis rs7312933 0.934 rs11181289 chr12:42402342 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.41 5.24 0.31 3.28e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs991427 0.643 rs17018718 chr12:91498199 C/T cg01859340 chr18:44775576 NA -0.66 -6.1 -0.35 3.79e-9 Systolic blood pressure (alcohol consumption interaction); CESC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg12143784 chr7:64541923 NA 0.41 5.45 0.32 1.18e-7 Calcium levels; CESC cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs9522267 0.535 rs914031 chr13:112240176 C/A cg10483660 chr13:112241077 NA -0.33 -5.84 -0.34 1.54e-8 Hepatitis; CESC cis rs372883 0.648 rs11088117 chr21:30737816 G/C cg24692254 chr21:30365293 RNF160 0.52 6.54 0.37 3.21e-10 Pancreatic cancer; CESC cis rs10504229 0.636 rs77691549 chr8:58055126 G/T cg24829409 chr8:58192753 C8orf71 -0.57 -6.58 -0.37 2.54e-10 Developmental language disorder (linguistic errors); CESC cis rs4722166 0.598 rs4722171 chr7:22785717 A/G cg26061582 chr7:22766209 IL6 0.5 5.48 0.32 9.97e-8 Lung cancer; CESC cis rs17789174 0.810 rs8051308 chr16:85081953 A/G cg01766882 chr16:85496273 NA -0.47 -5.15 -0.3 5.07e-7 Dysphagia; CESC cis rs1267303 0.798 rs1267304 chr1:46990426 C/T cg25110126 chr1:46999211 NA -0.69 -7.98 -0.44 4.49e-14 Monobrow; CESC cis rs2191566 0.691 rs8104802 chr19:44588969 G/A cg20607764 chr19:44506953 ZNF230 -0.4 -5.31 -0.31 2.33e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs1577917 1.000 rs34852683 chr6:86702330 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -5.63 -0.33 4.56e-8 Response to antipsychotic treatment; CESC cis rs12136530 0.593 rs4911989 chr1:19727743 C/G cg01832549 chr1:19774989 CAPZB 0.45 6.17 0.35 2.5e-9 Lead levels in blood; CESC cis rs13242816 1.000 rs35538349 chr7:116117896 C/T cg04696780 chr7:116139425 CAV2 -0.62 -5.46 -0.32 1.09e-7 P wave duration; CESC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.59 0.38 2.35e-10 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08647641 chr7:91763896 CYP51A1 -0.44 -6.42 -0.37 6.35e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24391471 chr3:44974926 ZDHHC3 -0.56 -6.06 -0.35 4.61e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.679 rs16921676 chr8:58052386 G/T cg02725872 chr8:58115012 NA -0.34 -5.15 -0.3 5.21e-7 Developmental language disorder (linguistic errors); CESC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg27535305 chr1:53392650 SCP2 0.35 6.21 0.36 2.01e-9 Monocyte count; CESC cis rs56036086 0.824 rs73187254 chr22:50642359 C/T cg16473166 chr22:50639996 SELO 0.62 5.1 0.3 6.6e-7 Platelet count;Plateletcrit; CESC cis rs2629540 0.847 rs10901811 chr10:126417914 G/A cg08799069 chr10:126477246 METTL10 0.58 7.55 0.42 7.26e-13 Cocaine dependence; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23831927 chr13:20989645 CRYL1 0.5 6.91 0.39 3.61e-11 Fibrinogen levels; CESC cis rs10463316 0.894 rs7723016 chr5:150764828 T/C cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC cis rs17376456 0.542 rs1453003 chr5:93151611 T/C cg25358565 chr5:93447407 FAM172A -0.71 -7.57 -0.42 6.21e-13 Diabetic retinopathy; CESC cis rs8067354 0.958 rs2777889 chr17:57848006 A/G cg13753209 chr17:57696993 CLTC 0.5 6.75 0.38 9.33e-11 Hemoglobin concentration; CESC cis rs1185460 0.967 rs1307145 chr11:118950217 C/G cg23280166 chr11:118938394 VPS11 0.54 7.35 0.41 2.54e-12 Coronary artery disease; CESC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg19163074 chr7:65112434 INTS4L2 -0.46 -5.52 -0.32 8.14e-8 Calcium levels; CESC cis rs4253772 0.530 rs9615955 chr22:46743931 A/G cg18190219 chr22:46762943 CELSR1 -0.68 -6.18 -0.36 2.35e-9 LDL cholesterol;Cholesterol, total; CESC cis rs6598955 0.724 rs12726972 chr1:26639634 A/G cg00852783 chr1:26633632 UBXN11 -0.38 -5.61 -0.33 5.2e-8 Obesity-related traits; CESC cis rs537626 1.000 rs612611 chr11:69307463 A/G cg08353955 chr11:69289746 NA -0.59 -6.36 -0.36 8.9e-10 Breast cancer (early onset); CESC cis rs1707322 1.000 rs11211228 chr1:46399840 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7178572 0.962 rs12324627 chr15:77767539 A/G cg22256960 chr15:77711686 NA -0.6 -8.09 -0.44 2.19e-14 Type 2 diabetes; CESC cis rs6430585 0.536 rs60397494 chr2:136470219 C/T cg07169764 chr2:136633963 MCM6 1.25 14.03 0.65 7.82e-34 Corneal structure; CESC cis rs6460942 1.000 rs7791634 chr7:12401482 A/T cg17427002 chr7:12443146 VWDE -0.51 -5.04 -0.3 8.8e-7 Coronary artery disease; CESC cis rs501120 0.866 rs607609 chr10:44750209 T/C cg09554077 chr10:44749378 NA 0.5 6.65 0.38 1.71e-10 Coronary artery disease;Coronary heart disease; CESC cis rs7399018 0.739 rs10747608 chr12:51616582 A/G cg25754956 chr12:51612065 POU6F1 0.69 8.77 0.47 2.18e-16 Cisplatin-induced ototoxicity; CESC cis rs4727027 0.866 rs2373437 chr7:148779032 T/C cg23583168 chr7:148888333 NA -0.78 -11.69 -0.58 1.01e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4319547 0.774 rs7295105 chr12:123124225 G/A cg23029597 chr12:123009494 RSRC2 -0.45 -5.18 -0.3 4.34e-7 Body mass index; CESC trans rs7989524 1.000 rs9318655 chr13:19633215 C/T cg14825340 chr8:26681894 ADRA1A -0.59 -6.02 -0.35 5.87e-9 Schizophrenia; CESC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg13012494 chr21:47604986 C21orf56 0.44 5.86 0.34 1.37e-8 Testicular germ cell tumor; CESC cis rs1801251 0.896 rs4973561 chr2:233687337 C/G cg08000102 chr2:233561755 GIGYF2 -0.68 -10.57 -0.54 5.21e-22 Coronary artery disease; CESC cis rs61841072 1.000 rs61841071 chr1:243129358 C/A cg02356786 chr1:243265016 LOC731275 0.41 5.26 0.31 2.97e-7 Schizophrenia; CESC cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg10845886 chr2:3471009 TTC15 -0.68 -9.33 -0.5 4.29e-18 Neurofibrillary tangles; CESC cis rs1878931 0.696 rs35175748 chr16:3445427 C/G cg21433313 chr16:3507492 NAT15 -0.39 -5.78 -0.33 2.12e-8 Body mass index (adult); CESC cis rs4808199 0.948 rs968525 chr19:19459215 C/T cg03709012 chr19:19516395 GATAD2A 1.06 12.11 0.6 3.63e-27 Nonalcoholic fatty liver disease; CESC cis rs4803468 0.967 rs16975238 chr19:41944985 T/A cg14132834 chr19:41945861 ATP5SL 0.6 7.5 0.42 9.35e-13 Height; CESC cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg16339924 chr4:17578868 LAP3 -0.79 -10.12 -0.53 1.43e-20 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8031584 0.651 rs28664821 chr15:31172323 G/A cg14829155 chr15:31115871 NA 0.82 12.33 0.6 6.32e-28 Huntington's disease progression; CESC cis rs6460942 0.544 rs34644264 chr7:12536090 C/A cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs8077889 0.750 rs72836564 chr17:41935064 G/A cg26893861 chr17:41843967 DUSP3 0.86 8.42 0.46 2.39e-15 Triglycerides; CESC cis rs4474465 0.915 rs4944204 chr11:78222013 G/T cg27205649 chr11:78285834 NARS2 0.45 5.36 0.31 1.81e-7 Alzheimer's disease (survival time); CESC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg23034840 chr1:205782522 SLC41A1 0.68 8.4 0.46 2.75e-15 Menarche (age at onset); CESC cis rs113835537 0.529 rs11227503 chr11:66275242 G/C cg24851651 chr11:66362959 CCS 0.44 5.46 0.32 1.11e-7 Airway imaging phenotypes; CESC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg26566898 chr11:117069891 TAGLN -0.32 -5.47 -0.32 1.06e-7 Blood protein levels; CESC cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg06028605 chr16:24865363 SLC5A11 -0.4 -6.1 -0.35 3.71e-9 Intelligence (multi-trait analysis); CESC cis rs3126085 0.935 rs1390485 chr1:152182168 C/T cg26876637 chr1:152193138 HRNR -0.44 -5.03 -0.3 9.04e-7 Atopic dermatitis; CESC cis rs7927771 0.524 rs10838740 chr11:47679980 A/G cg18512352 chr11:47633146 NA 0.35 5.4 0.31 1.51e-7 Subjective well-being; CESC cis rs4974559 0.501 rs730830 chr4:1240091 T/C cg02980000 chr4:1222292 CTBP1 -0.76 -7.67 -0.43 3.31e-13 Systolic blood pressure; CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg18402987 chr7:1209562 NA 0.61 7.2 0.4 6.1e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1008375 0.898 rs7678654 chr4:17575376 T/G cg02297831 chr4:17616191 MED28 0.5 6.05 0.35 4.9e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg04267008 chr7:1944627 MAD1L1 -0.71 -9.06 -0.49 2.86e-17 Bipolar disorder and schizophrenia; CESC cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.95e-9 Extrinsic epigenetic age acceleration; CESC cis rs4242434 0.927 rs10095121 chr8:22538426 A/G cg03733263 chr8:22462867 KIAA1967 0.93 13.14 0.63 1.04e-30 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs2243480 1.000 rs316304 chr7:65616894 T/C cg13147721 chr7:65941812 NA -0.98 -9.23 -0.49 9.18e-18 Diabetic kidney disease; CESC cis rs941873 0.900 rs7092536 chr10:81131332 A/C cg09469691 chr10:81107165 PPIF 0.53 7.32 0.41 2.88e-12 Height; CESC cis rs854765 0.927 rs4925138 chr17:17992793 T/G cg16928487 chr17:17741425 SREBF1 0.58 9.78 0.51 1.75e-19 Total body bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18382590 chr9:131219195 ODF2 -0.49 -7.02 -0.4 1.86e-11 Gambling; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05725452 chr22:21996709 SDF2L1 -0.49 -6.89 -0.39 4.13e-11 Gut microbiota (bacterial taxa); CESC cis rs6121246 0.909 rs6060929 chr20:30345914 C/T cg13852791 chr20:30311386 BCL2L1 0.81 8.61 0.47 6.48e-16 Mean corpuscular hemoglobin; CESC cis rs9457247 1.000 rs2149091 chr6:167372786 C/T cg07741184 chr6:167504864 NA -0.3 -5.39 -0.31 1.6e-7 Crohn's disease; CESC cis rs2991971 0.901 rs11211122 chr1:45954650 C/T cg15605315 chr1:45957053 TESK2 0.46 6.14 0.35 2.94e-9 High light scatter reticulocyte count; CESC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg18404041 chr3:52824283 ITIH1 0.39 5.95 0.34 8.49e-9 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02819828 chr13:37453855 SMAD9 0.42 6.22 0.36 1.97e-9 Fibrinogen levels; CESC cis rs977987 0.872 rs4887825 chr16:75472422 C/A cg03315344 chr16:75512273 CHST6 0.42 6.12 0.35 3.38e-9 Dupuytren's disease; CESC cis rs4835473 0.900 rs13101531 chr4:144903350 G/T cg25736465 chr4:144833511 NA -0.43 -6.49 -0.37 4.21e-10 Immature fraction of reticulocytes; CESC cis rs4595586 0.525 rs10506132 chr12:39404599 C/T cg26384229 chr12:38710491 ALG10B 0.61 8.57 0.47 8.88e-16 Morning vs. evening chronotype; CESC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg22307029 chr19:49891270 CCDC155 0.72 8.46 0.46 1.82e-15 Multiple sclerosis; CESC cis rs4547160 0.781 rs10877951 chr12:63485882 T/C cg26727693 chr12:63544175 AVPR1A -0.34 -5.12 -0.3 5.82e-7 Morning vs. evening chronotype; CESC cis rs35740288 0.597 rs12900830 chr15:86326154 T/C cg20737812 chr15:86336631 KLHL25 -0.47 -5.41 -0.32 1.39e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs16866061 0.926 rs17479770 chr2:225335814 A/G cg12698349 chr2:225449008 CUL3 0.69 9.89 0.52 7.79e-20 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs863345 0.604 rs949397 chr1:158461951 G/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.29 -0.41 3.49e-12 Pneumococcal bacteremia; CESC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg23590916 chr17:43697445 MGC57346 -0.62 -6.63 -0.38 1.84e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1355223 0.833 rs11032804 chr11:34680598 C/A cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.13 -0.35 3.2e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6800768 0.633 rs826373 chr3:24163773 C/G cg10674438 chr3:24145617 LOC152024 -0.48 -6.92 -0.39 3.33e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8018808 1.000 rs12435136 chr14:77856184 G/A cg20045696 chr14:77926864 AHSA1 -0.44 -6.14 -0.35 3.05e-9 Myeloid white cell count; CESC cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg19626725 chr5:178986131 RUFY1 0.4 6.4 0.37 6.99e-10 Lung cancer; CESC cis rs7917772 0.636 rs2482499 chr10:104516246 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.44 5.1 0.3 6.41e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs798766 1.000 rs798755 chr4:1720824 A/G cg07041428 chr4:1763019 NA -0.39 -5.66 -0.33 3.86e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs9815354 0.680 rs114478966 chr3:42007050 T/C cg03022575 chr3:42003672 ULK4 0.67 6.27 0.36 1.43e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs116095464 0.558 rs1812843 chr5:267658 A/G cg22857025 chr5:266934 NA -1.3 -18.55 -0.75 8.05e-50 Breast cancer; CESC cis rs1059312 0.966 rs7135968 chr12:129280066 G/A cg09035930 chr12:129282057 SLC15A4 0.76 10.73 0.55 1.59e-22 Systemic lupus erythematosus; CESC cis rs9915657 0.870 rs4140903 chr17:70133771 C/T cg06234051 chr17:70120541 SOX9 -0.44 -6.5 -0.37 4.06e-10 Thyroid hormone levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21771171 chr6:692465 EXOC2 -0.43 -6.08 -0.35 4.18e-9 Gambling; CESC cis rs10870270 1.000 rs11146338 chr10:133770291 C/G cg26149184 chr10:133730230 NA 0.38 5.14 0.3 5.22e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs35110281 0.720 rs162392 chr21:44941406 A/G cg01579765 chr21:45077557 HSF2BP -0.54 -9.15 -0.49 1.58e-17 Mean corpuscular volume; CESC cis rs11098499 0.605 rs6833140 chr4:120266822 G/A cg09307838 chr4:120376055 NA 0.75 9.66 0.51 4.11e-19 Corneal astigmatism; CESC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg10691866 chr7:65817282 TPST1 0.33 5.47 0.32 1.02e-7 Aortic root size; CESC cis rs9287719 0.967 rs6761678 chr2:10746341 T/C cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg02807482 chr3:125708958 NA -0.38 -5.08 -0.3 7.16e-7 Blood pressure (smoking interaction); CESC cis rs9926296 0.533 rs12102297 chr16:89812762 C/A cg07648498 chr16:89883185 FANCA 0.49 6.21 0.36 1.99e-9 Vitiligo; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10828910 chr2:63850056 LOC388955 -0.5 -6.71 -0.38 1.17e-10 Gut microbiota (bacterial taxa); CESC cis rs9611565 0.569 rs188057 chr22:41822305 T/G cg17376030 chr22:41985996 PMM1 -0.76 -8.01 -0.44 3.71e-14 Vitiligo; CESC cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg27478167 chr7:817139 HEATR2 -0.45 -5.27 -0.31 2.81e-7 Cerebrospinal P-tau181p levels; CESC cis rs34779708 0.966 rs10827493 chr10:35454976 C/T cg03585969 chr10:35415529 CREM 0.77 10.56 0.54 5.56e-22 Inflammatory bowel disease;Crohn's disease; CESC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.32 0.36 1.11e-9 Menopause (age at onset); CESC cis rs863345 0.967 rs10908683 chr1:158522770 C/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.5 -0.37 3.89e-10 Pneumococcal bacteremia; CESC cis rs4604732 0.678 rs74154674 chr1:247625685 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs709400 0.930 rs10149249 chr14:104047757 C/T cg24130564 chr14:104152367 KLC1 -0.43 -5.33 -0.31 2.06e-7 Body mass index; CESC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg04287289 chr16:89883240 FANCA 0.87 14.87 0.67 8.54e-37 Vitiligo; CESC cis rs7123876 0.553 rs12099027 chr11:72433920 A/G cg03713592 chr11:72463424 ARAP1 0.44 5.21 0.31 3.71e-7 Body mass index; CESC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg12311346 chr5:56204834 C5orf35 -0.47 -5.69 -0.33 3.41e-8 Coronary artery disease; CESC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.38 -5.76 -0.33 2.3e-8 Personality dimensions; CESC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg11301795 chr4:187892539 NA -0.75 -12.33 -0.6 6.74e-28 Lobe attachment (rater-scored or self-reported); CESC trans rs9929218 0.559 rs55907909 chr16:68805805 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.86 13.93 0.65 1.77e-33 Colorectal cancer; CESC cis rs763121 0.853 rs138704 chr22:39133410 A/G cg14440974 chr22:39074834 NA -0.36 -5.27 -0.31 2.9e-7 Menopause (age at onset); CESC cis rs9837602 0.529 rs1688774 chr3:99521108 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.52 -6.21 -0.36 2.05e-9 Breast cancer; CESC cis rs8058578 0.887 rs28421305 chr16:30838128 G/A cg00531865 chr16:30841666 NA -0.41 -5.34 -0.31 2.02e-7 Multiple myeloma; CESC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.53 7.7 0.43 2.75e-13 Bipolar disorder; CESC cis rs12545109 0.800 rs2610052 chr8:57411316 C/A cg09654669 chr8:57350985 NA -0.47 -6.38 -0.36 8.01e-10 Obesity-related traits; CESC trans rs1728785 0.892 rs1103955 chr16:68588488 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.82 0.43 1.24e-13 Ulcerative colitis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20685139 chr19:53238254 ZNF611 0.46 6.24 0.36 1.69e-9 Asthma; CESC cis rs8016982 0.963 rs7149672 chr14:81657336 A/G cg01989461 chr14:81687754 GTF2A1 0.52 6.62 0.38 1.98e-10 Schizophrenia; CESC cis rs778371 0.723 rs6704763 chr2:233592487 C/T cg08000102 chr2:233561755 GIGYF2 0.85 15.12 0.68 1.13e-37 Schizophrenia; CESC cis rs2072732 0.861 rs10909867 chr1:2961402 G/T cg03976712 chr1:2946727 NA 0.35 5.63 0.33 4.52e-8 Plateletcrit; CESC trans rs116095464 0.558 rs113796397 chr5:246503 A/G cg00938859 chr5:1591904 SDHAP3 0.64 6.65 0.38 1.68e-10 Breast cancer; CESC cis rs2742234 0.541 rs1879310 chr10:43734775 A/G cg15436174 chr10:43711423 RASGEF1A 0.46 5.41 0.32 1.39e-7 Hirschsprung disease; CESC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg19592336 chr6:28129416 ZNF389 0.54 6.94 0.39 3e-11 Parkinson's disease; CESC cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg00745463 chr17:30367425 LRRC37B -0.86 -7.74 -0.43 2.15e-13 Hip circumference adjusted for BMI; CESC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg25072359 chr17:41440525 NA 0.46 6.1 0.35 3.77e-9 Menopause (age at onset); CESC cis rs7264396 0.563 rs17093093 chr20:34380925 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.66 6.74 0.38 9.78e-11 Total cholesterol levels; CESC cis rs916888 0.821 rs199509 chr17:44858728 G/A cg01570182 chr17:44337453 NA -0.87 -10.59 -0.55 4.47e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9487051 0.766 rs351748 chr6:109532296 C/T cg01475377 chr6:109611718 NA 0.4 5.98 0.35 7.01e-9 Reticulocyte fraction of red cells; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg10068917 chr8:63952060 GGH -0.45 -6.45 -0.37 5.38e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs116095464 0.558 rs10475136 chr5:232796 A/G cg22496380 chr5:211416 CCDC127 -0.73 -8.37 -0.46 3.25e-15 Breast cancer; CESC cis rs72781680 1.000 rs56205282 chr2:24221317 C/T cg20701182 chr2:24300061 SF3B14 0.81 6.96 0.39 2.71e-11 Lymphocyte counts; CESC cis rs9486715 0.867 rs211159 chr6:97023026 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -11.86 -0.59 2.51e-26 Headache; CESC cis rs9640161 0.750 rs59211922 chr7:150023790 T/G cg21361702 chr7:150065534 REPIN1 0.45 5.29 0.31 2.6e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg06873352 chr17:61820015 STRADA 0.47 6.85 0.39 5.3e-11 Height; CESC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg17971929 chr21:40555470 PSMG1 -0.85 -12.29 -0.6 9.04e-28 Cognitive function; CESC cis rs7918232 1.000 rs6482595 chr10:27380261 A/G cg14240646 chr10:27532245 ACBD5 0.55 5.82 0.34 1.69e-8 Breast cancer; CESC cis rs889312 0.500 rs832580 chr5:56172646 T/C cg12311346 chr5:56204834 C5orf35 -0.4 -5.03 -0.3 8.87e-7 Breast cancer;Breast cancer (early onset); CESC cis rs3096299 0.781 rs2170839 chr16:89409452 C/G cg02187348 chr16:89574699 SPG7 0.5 6.13 0.35 3.17e-9 Multiple myeloma (IgH translocation); CESC cis rs1009170 0.794 rs7158971 chr14:92586126 T/A cg10324096 chr14:92587714 CPSF2;NDUFB1 0.53 5.03 0.3 9.1e-7 Dialysis-related mortality; CESC cis rs1046896 1.000 rs28485881 chr17:80690014 G/A cg02711726 chr17:80685570 FN3KRP -0.57 -8.56 -0.47 9.56e-16 Glycated hemoglobin levels; CESC cis rs7267979 0.932 rs449370 chr20:25451180 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.81 -0.72 1.13e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs11122272 0.701 rs2491402 chr1:231494338 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -6.48 -0.37 4.4e-10 Hemoglobin concentration; CESC cis rs4764487 0.760 rs10849421 chr12:6327008 A/G cg08284733 chr12:6341482 CD9 0.41 6.04 0.35 5.21e-9 Mean platelet volume; CESC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.57 0.37 2.6e-10 Bipolar disorder; CESC cis rs7577696 0.568 rs7574000 chr2:32342888 A/C cg02381751 chr2:32503542 YIPF4 -0.42 -5.05 -0.3 8.31e-7 Inflammatory biomarkers; CESC cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -6.81 -0.39 6.64e-11 Personality dimensions; CESC cis rs77106637 1.000 rs11602858 chr11:72615069 C/G cg04827223 chr11:72435913 ARAP1 -0.5 -5.32 -0.31 2.26e-7 Type 2 diabetes; CESC cis rs7202877 0.706 rs247425 chr16:75460402 C/T cg04384234 chr16:75411784 CFDP1 0.48 5.68 0.33 3.51e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs644799 1.000 rs543530 chr11:95545170 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4568518 0.740 rs10429191 chr7:18009097 G/A cg03009463 chr7:17980271 SNX13 0.46 6.0 0.35 6.45e-9 Measles; CESC cis rs1034435 0.755 rs5767173 chr22:48892473 T/C cg05992904 chr22:48892994 FAM19A5 -0.56 -9.93 -0.52 6e-20 Late-onset Alzheimer's disease; CESC cis rs7481584 0.624 rs693687 chr11:3052494 A/G cg08508325 chr11:3079039 CARS 0.29 5.2 0.3 3.96e-7 Calcium levels; CESC cis rs4253772 0.591 rs11703245 chr22:46684890 A/G cg00784671 chr22:46762841 CELSR1 -0.57 -5.47 -0.32 1.03e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6693567 0.586 rs9661040 chr1:150483236 A/C cg09579323 chr1:150459698 TARS2 0.47 5.85 0.34 1.41e-8 Migraine; CESC cis rs6964587 1.000 rs3753107 chr7:91629151 C/T cg17063962 chr7:91808500 NA -0.56 -7.7 -0.43 2.64e-13 Breast cancer; CESC cis rs3733585 0.673 rs4447861 chr4:9953940 C/T cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs61776719 0.520 rs72661887 chr1:38416310 C/T cg12658694 chr1:38397304 INPP5B 0.64 9.15 0.49 1.55e-17 Coronary artery disease; CESC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.53 7.89 0.44 7.99e-14 Bipolar disorder; CESC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg27535305 chr1:53392650 SCP2 -0.33 -5.42 -0.32 1.31e-7 Monocyte count; CESC cis rs12497850 0.863 rs4974084 chr3:48939080 G/A cg07636037 chr3:49044803 WDR6 1.03 19.22 0.76 3.77e-52 Parkinson's disease; CESC cis rs6088580 0.634 rs6088483 chr20:32984714 T/A cg24642439 chr20:33292090 TP53INP2 -0.53 -6.98 -0.39 2.39e-11 Glomerular filtration rate (creatinine); CESC cis rs1448094 0.791 rs10863110 chr12:86328523 T/C cg02569458 chr12:86230093 RASSF9 0.45 6.43 0.37 5.79e-10 Major depressive disorder; CESC cis rs4478858 0.806 rs6686845 chr1:31708796 A/T cg00250761 chr1:31883323 NA -0.28 -5.39 -0.31 1.57e-7 Alcohol dependence; CESC cis rs6964587 1.000 rs2282968 chr7:91580287 A/C cg17063962 chr7:91808500 NA -0.54 -7.12 -0.4 9.86e-12 Breast cancer; CESC cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg03467027 chr4:99064603 C4orf37 0.43 5.35 0.31 1.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg03538708 chr1:25844672 NA -0.38 -5.79 -0.33 2.02e-8 Erythrocyte sedimentation rate; CESC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg23281280 chr6:28129359 ZNF389 0.5 6.51 0.37 3.72e-10 Parkinson's disease; CESC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg01416388 chr22:39784598 NA -0.6 -7.47 -0.42 1.19e-12 Intelligence (multi-trait analysis); CESC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg03934478 chr11:495069 RNH1 0.56 5.41 0.32 1.38e-7 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20413923 chr1:27022645 ARID1A 0.51 6.02 0.35 5.88e-9 Gut microbiome composition (summer); CESC cis rs3015497 0.603 rs3015447 chr14:51082586 T/C cg26011998 chr14:51135199 SAV1 -0.47 -5.38 -0.31 1.6e-7 Mean platelet volume; CESC cis rs9308731 0.644 rs3789065 chr2:111915022 C/G cg04202892 chr2:111875749 ACOXL 0.44 6.43 0.37 5.83e-10 Chronic lymphocytic leukemia; CESC cis rs6732160 0.657 rs10171459 chr2:73434728 A/C cg01422370 chr2:73384389 NA 0.44 7.38 0.41 1.99e-12 Intelligence (multi-trait analysis); CESC cis rs77106637 0.929 rs74333814 chr11:72457487 C/T cg04827223 chr11:72435913 ARAP1 -0.57 -5.49 -0.32 9.2e-8 Type 2 diabetes; CESC cis rs708547 0.647 rs1626594 chr4:57878254 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.47 6.61 0.38 2.11e-10 Response to bleomycin (chromatid breaks); CESC cis rs684232 0.666 rs2254134 chr17:628664 A/G cg15660573 chr17:549704 VPS53 -0.6 -8.04 -0.44 2.94e-14 Prostate cancer; CESC cis rs7659604 0.502 rs10212738 chr4:122675724 G/A cg19671926 chr4:122722719 EXOSC9 0.53 6.7 0.38 1.21e-10 Type 2 diabetes; CESC cis rs9583531 0.574 rs7319459 chr13:111352408 T/C cg24331049 chr13:111365604 ING1 -0.71 -10.41 -0.54 1.66e-21 Coronary artery disease; CESC cis rs9457247 1.000 rs394522 chr6:167398071 A/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.43 -0.46 2.21e-15 Crohn's disease; CESC cis rs763121 0.853 rs5750652 chr22:39048316 A/G cg06544989 chr22:39130855 UNC84B 0.5 9.27 0.49 6.78e-18 Menopause (age at onset); CESC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg04414720 chr1:150670196 GOLPH3L 0.63 9.04 0.49 3.47e-17 Tonsillectomy; CESC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg11890956 chr21:40555474 PSMG1 1.16 21.18 0.79 6.14e-59 Cognitive function; CESC cis rs4604732 0.631 rs10754561 chr1:247622800 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.37 5.19 0.3 4.17e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7666738 0.830 rs7659006 chr4:98934529 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs11997175 0.574 rs4733456 chr8:33656359 C/T ch.8.33884649F chr8:33765107 NA 0.66 8.69 0.47 3.79e-16 Body mass index; CESC cis rs1878931 0.567 rs7196196 chr16:3411855 C/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.96 14.37 0.66 5.2e-35 Body mass index (adult); CESC cis rs9815354 0.597 rs17283481 chr3:41924015 T/C cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs4604732 0.536 rs4925674 chr1:247636906 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.92 0.44 6.57e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6867032 0.958 rs4975797 chr5:2015573 G/A cg26168224 chr5:2018326 NA 0.96 19.64 0.77 1.3e-53 Gut microbiome composition (winter); CESC cis rs57506017 0.585 rs6460902 chr7:12255511 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.25 0.31 3.16e-7 Neuroticism; CESC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg20607287 chr7:12443886 VWDE -0.67 -8.34 -0.46 4.15e-15 Coronary artery disease; CESC cis rs3087591 0.887 rs1013946 chr17:29530350 A/C cg24425628 chr17:29625626 OMG;NF1 0.43 5.28 0.31 2.71e-7 Hip circumference; CESC cis rs9303401 0.614 rs3803753 chr17:56540110 G/A cg25039879 chr17:56429692 SUPT4H1 0.53 5.39 0.31 1.55e-7 Cognitive test performance; CESC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg23048001 chr7:2026167 MAD1L1 0.5 6.56 0.37 2.85e-10 Bipolar disorder and schizophrenia; CESC cis rs6723226 0.679 rs116617324 chr2:32622709 C/T cg02381751 chr2:32503542 YIPF4 -0.56 -7.28 -0.41 3.86e-12 Intelligence (multi-trait analysis); CESC cis rs412050 0.793 rs74576380 chr22:22283280 A/G cg17089214 chr22:22089827 YPEL1 0.68 5.8 0.34 1.91e-8 Attention deficit hyperactivity disorder; CESC cis rs2072499 0.833 rs2251847 chr1:156204047 G/A cg25208724 chr1:156163844 SLC25A44 0.83 13.26 0.63 3.87e-31 Testicular germ cell tumor; CESC trans rs3942852 0.703 rs11039513 chr11:48107204 C/T cg03929089 chr4:120376271 NA 0.59 7.16 0.4 7.95e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs2236918 0.932 rs1635501 chr1:242040775 C/T cg17736920 chr1:242011382 EXO1 0.57 7.79 0.43 1.52e-13 Menopause (age at onset); CESC cis rs17854409 0.881 rs68091818 chr20:61479882 A/C cg07645718 chr20:61493192 TCFL5 0.82 6.0 0.35 6.51e-9 Obesity-related traits; CESC cis rs854765 0.964 rs854810 chr17:18006421 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.46 -6.09 -0.35 3.92e-9 Total body bone mineral density; CESC cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg10523679 chr1:76189770 ACADM 0.73 8.74 0.47 2.81e-16 Blood metabolite levels;Acylcarnitine levels; CESC trans rs17685 0.753 rs2868203 chr7:75680026 G/A cg19862616 chr7:65841803 NCRNA00174 -0.84 -12.47 -0.61 2.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC trans rs9929218 0.551 rs9888942 chr16:68727572 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.93 15.66 0.69 1.35e-39 Colorectal cancer; CESC cis rs9914988 0.887 rs12948575 chr17:27130520 G/A cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg15813090 chr5:442598 EXOC3;C5orf55 0.41 6.22 0.36 1.89e-9 Cystic fibrosis severity; CESC trans rs3942852 0.703 rs11039513 chr11:48107204 C/T cg15704280 chr7:45808275 SEPT13 0.68 8.61 0.47 6.57e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs1865760 0.566 rs9358904 chr6:26068566 C/T cg17691542 chr6:26056736 HIST1H1C 0.44 5.86 0.34 1.4e-8 Height; CESC cis rs2228479 0.850 rs11076624 chr16:89855749 T/C cg06558623 chr16:89946397 TCF25 1.18 9.44 0.5 1.97e-18 Skin colour saturation; CESC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs734999 0.588 rs745367 chr1:2524457 T/C cg20673091 chr1:2541236 MMEL1 0.43 7.25 0.41 4.49e-12 Ulcerative colitis; CESC cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg03060546 chr3:49711283 APEH 0.44 5.38 0.31 1.61e-7 Parkinson's disease; CESC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.56 0.47 9.4e-16 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16506072 chr16:85833520 COX4NB;COX4I1 -0.41 -6.35 -0.36 9.11e-10 Gambling; CESC cis rs208520 0.874 rs208518 chr6:66948501 C/G cg07460842 chr6:66804631 NA 0.89 10.69 0.55 2.12e-22 Exhaled nitric oxide output; CESC cis rs4588572 0.643 rs7700390 chr5:77789532 T/C cg11547950 chr5:77652471 NA -0.45 -5.74 -0.33 2.53e-8 Triglycerides; CESC cis rs858239 1.000 rs199347 chr7:23293746 A/G cg23682824 chr7:23144976 KLHL7 0.4 5.34 0.31 2.01e-7 Cerebrospinal fluid biomarker levels; CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.39 -7.52 -0.42 8.27e-13 Electroencephalogram traits; CESC trans rs11098499 0.739 rs10013032 chr4:120149419 C/T cg25214090 chr10:38739885 LOC399744 -0.56 -7.5 -0.42 9.44e-13 Corneal astigmatism; CESC cis rs9309473 0.898 rs7587577 chr2:73832786 C/T cg20560298 chr2:73613845 ALMS1 -0.54 -7.04 -0.4 1.6e-11 Metabolite levels; CESC cis rs6598955 0.515 rs61776655 chr1:26541430 T/C cg04990556 chr1:26633338 UBXN11 -0.71 -9.87 -0.52 8.96e-20 Obesity-related traits; CESC trans rs473518 0.891 rs554133 chr18:20103754 C/T cg20346503 chr2:128994402 NA -0.45 -6.06 -0.35 4.69e-9 Migraine - clinic-based; CESC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg20887711 chr4:1340912 KIAA1530 0.65 8.85 0.48 1.26e-16 Longevity; CESC cis rs2124969 0.548 rs62175384 chr2:161011128 C/T cg03641300 chr2:160917029 PLA2R1 -0.57 -5.87 -0.34 1.29e-8 Waist circumference adjusted for body mass index; CESC cis rs6088590 0.930 rs6120723 chr20:33364655 C/T cg24642439 chr20:33292090 TP53INP2 0.84 11.81 0.59 3.81e-26 Coronary artery disease; CESC cis rs875971 0.545 rs7810213 chr7:65946579 G/C cg25405998 chr7:65216604 CCT6P1 0.5 5.36 0.31 1.81e-7 Aortic root size; CESC cis rs11638352 0.661 rs11857696 chr15:44366258 T/A cg02155558 chr15:43621948 ADAL;LCMT2 -0.5 -5.46 -0.32 1.09e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg17949981 chr6:28129498 ZNF389 -0.41 -5.2 -0.3 4.08e-7 Depression; CESC trans rs561341 1.000 rs72825740 chr17:30338356 A/G cg27661571 chr11:113659931 NA -0.86 -7.65 -0.43 3.84e-13 Hip circumference adjusted for BMI; CESC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.71 0.33 3.01e-8 Menopause (age at onset); CESC cis rs9660992 0.649 rs72745216 chr1:205261016 G/A cg21643547 chr1:205240462 TMCC2 -0.47 -6.25 -0.36 1.6e-9 Mean corpuscular volume;Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00298532 chr1:9790325 CLSTN1 -0.59 -6.56 -0.37 2.78e-10 Gut microbiome composition (summer); CESC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg06808227 chr14:105710500 BRF1 -0.59 -7.1 -0.4 1.16e-11 Mean platelet volume;Platelet distribution width; CESC cis rs7223966 1.000 rs78172786 chr17:61847114 A/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.08 -0.3 7.28e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs10911232 0.507 rs4652765 chr1:182994147 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs7100689 0.646 rs6585946 chr10:82118292 G/T cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs8053891 0.615 rs3794695 chr16:72097827 C/T cg01557791 chr16:72042693 DHODH -0.51 -5.17 -0.3 4.73e-7 Coronary artery disease; CESC cis rs4889855 0.556 rs3923514 chr17:78515210 A/G cg16591659 chr17:78472290 NA 0.37 5.93 0.34 9.29e-9 Fractional excretion of uric acid; CESC cis rs11098499 0.774 rs11098505 chr4:120284627 C/T cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs8077577 0.747 rs2071242 chr17:18154510 T/C cg16794390 chr17:18148240 FLII 0.41 6.24 0.36 1.69e-9 Obesity-related traits; CESC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg09177884 chr7:1199841 ZFAND2A -0.52 -6.64 -0.38 1.73e-10 Longevity;Endometriosis; CESC cis rs2070488 0.965 rs35553573 chr3:38441439 C/T cg24069376 chr3:38537580 EXOG 0.46 8.43 0.46 2.31e-15 Electrocardiographic conduction measures; CESC cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg21918786 chr6:109611834 NA 0.37 5.59 0.32 5.7e-8 Reticulocyte fraction of red cells; CESC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg22105103 chr4:187893119 NA 0.5 7.32 0.41 2.98e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg13114125 chr14:105738426 BRF1 0.62 8.13 0.45 1.61e-14 Mean platelet volume;Platelet distribution width; CESC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg12373951 chr3:133503437 NA 0.38 5.32 0.31 2.23e-7 Iron status biomarkers; CESC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg04025307 chr7:1156635 C7orf50 0.39 6.28 0.36 1.4e-9 Longevity;Endometriosis; CESC cis rs9473147 0.543 rs9473126 chr6:47481833 C/G cg20196966 chr6:47445060 CD2AP 0.41 5.33 0.31 2.13e-7 Platelet distribution width;Mean platelet volume; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg10355708 chr8:145618298 ADCK5 -0.47 -6.21 -0.36 2.01e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg07701084 chr6:150067640 NUP43 0.41 5.57 0.32 6.14e-8 Lung cancer; CESC cis rs17253792 0.822 rs79618862 chr14:56093971 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.98 0.34 7.23e-9 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09509543 chr4:119757682 SEC24D -0.62 -6.84 -0.39 5.44e-11 Gut microbiome composition (summer); CESC cis rs10861342 0.579 rs77585712 chr12:105482251 T/C cg23923672 chr12:105501055 KIAA1033 0.71 5.31 0.31 2.29e-7 IgG glycosylation; CESC trans rs1728785 0.901 rs1728787 chr16:68593042 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.84 0.43 1.09e-13 Ulcerative colitis; CESC cis rs709400 1.000 rs57218990 chr14:104128007 T/A cg24130564 chr14:104152367 KLC1 -0.42 -5.42 -0.32 1.36e-7 Body mass index; CESC cis rs992157 0.700 rs10165153 chr2:219159629 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.02 0.48 3.81e-17 Colorectal cancer; CESC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26163375 chr1:1209720 UBE2J2 -0.48 -6.72 -0.38 1.12e-10 Fibrinogen levels; CESC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.18 -0.3 4.5e-7 Obesity-related traits; CESC cis rs977987 0.836 rs4888376 chr16:75322573 T/C cg03315344 chr16:75512273 CHST6 0.37 5.31 0.31 2.28e-7 Dupuytren's disease; CESC cis rs66530629 0.874 rs10903102 chr1:25122839 C/G cg22509179 chr1:25234806 RUNX3 -0.43 -5.47 -0.32 1.05e-7 Plateletcrit; CESC trans rs28549925 0.590 rs9690465 chr7:16987494 C/T cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.83e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs6502050 0.865 rs8073679 chr17:80155343 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.26 -0.31 3e-7 Life satisfaction; CESC cis rs55692411 0.517 rs62262106 chr3:49991427 A/G cg03060546 chr3:49711283 APEH -0.48 -5.53 -0.32 7.62e-8 Intelligence (multi-trait analysis); CESC cis rs6963495 0.745 rs55906043 chr7:105165367 T/G cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs11122272 0.735 rs2486745 chr1:231505717 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.42e-9 Hemoglobin concentration; CESC cis rs523522 0.962 rs11065154 chr12:120971417 T/C cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs79349575 0.749 rs957557 chr17:47003221 G/T cg26022315 chr17:47021804 SNF8 0.39 5.18 0.3 4.5e-7 Type 2 diabetes; CESC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg02951883 chr7:2050386 MAD1L1 0.46 6.03 0.35 5.44e-9 Bipolar disorder and schizophrenia; CESC cis rs300703 0.678 rs423643 chr2:199648 A/C cg21211680 chr2:198530 NA 1.02 10.81 0.55 8.46e-23 Blood protein levels; CESC cis rs11864453 0.612 rs11862813 chr16:72132356 C/T cg16558253 chr16:72132732 DHX38 -0.54 -8.48 -0.46 1.6e-15 Fibrinogen levels; CESC cis rs6543140 0.865 rs6760275 chr2:103079607 C/T cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14159963 chr7:116139849 CAV2 -0.47 -6.05 -0.35 4.87e-9 Fibrinogen levels; CESC cis rs7772486 0.875 rs2474356 chr6:146296798 G/A cg05347473 chr6:146136440 FBXO30 0.54 6.99 0.39 2.28e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs897984 0.683 rs8046001 chr16:30833321 C/T cg00531865 chr16:30841666 NA -0.58 -8.58 -0.47 8.14e-16 Dementia with Lewy bodies; CESC cis rs2370759 1.000 rs11599522 chr10:32568434 G/C cg01819863 chr10:32635814 EPC1 1.15 12.94 0.62 4.99e-30 Sexual dysfunction (female); CESC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg17971929 chr21:40555470 PSMG1 0.94 12.96 0.62 4.46e-30 Cognitive function; CESC cis rs10752881 1.000 rs8179282 chr1:182974598 C/G ch.1.3577855R chr1:183094577 LAMC1 0.83 13.12 0.63 1.19e-30 Colorectal cancer; CESC cis rs78456975 0.941 rs6755875 chr2:1557109 T/C cg26248373 chr2:1572462 NA -0.59 -5.7 -0.33 3.26e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg24846343 chr22:24311635 DDTL -0.67 -11.22 -0.57 3.6e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs72634258 0.699 rs2493214 chr1:7994420 A/G cg00042356 chr1:8021962 PARK7 0.46 5.33 0.31 2.15e-7 Inflammatory bowel disease; CESC cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg06753689 chr10:1034030 GTPBP4 0.5 5.03 0.3 8.97e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs698813 0.604 rs11676798 chr2:44479982 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.48 0.32 9.84e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs7520050 0.778 rs2991985 chr1:46080530 T/C cg03146154 chr1:46216737 IPP -0.51 -6.81 -0.39 6.4e-11 Red blood cell count;Reticulocyte count; CESC cis rs36051895 0.659 rs62541540 chr9:5040080 A/G cg02405213 chr9:5042618 JAK2 -0.48 -5.69 -0.33 3.28e-8 Pediatric autoimmune diseases; CESC cis rs9389248 0.737 rs12664956 chr6:135384188 T/C cg24558204 chr6:135376177 HBS1L 0.71 9.63 0.51 5.3e-19 High light scatter reticulocyte percentage of red cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27556566 chr18:29671984 RNF138 -0.47 -6.93 -0.39 3.13e-11 Gambling; CESC cis rs7208859 0.573 rs8078656 chr17:29080971 A/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10088262 0.629 rs7827665 chr8:124804190 G/A cg02993010 chr8:124780839 FAM91A1 -0.67 -8.56 -0.47 9.13e-16 Pancreatic cancer; CESC cis rs9488822 0.702 rs12196154 chr6:116327471 T/G cg26893134 chr6:116381904 FRK 0.25 6.02 0.35 5.89e-9 Cholesterol, total;LDL cholesterol; CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg23034840 chr1:205782522 SLC41A1 0.67 8.26 0.45 7.02e-15 Menarche (age at onset); CESC cis rs2625529 0.652 rs2957750 chr15:72332258 C/T cg16672083 chr15:72433130 SENP8 0.46 7.22 0.41 5.65e-12 Red blood cell count; CESC cis rs5758659 0.935 rs134879 chr22:42664201 A/C cg15557168 chr22:42548783 NA -0.5 -8.0 -0.44 3.92e-14 Cognitive function; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06564803 chr16:70100193 PDXDC2 0.41 6.1 0.35 3.84e-9 Systemic lupus erythematosus; CESC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg06221963 chr1:154839813 KCNN3 -0.7 -11.99 -0.59 9.73e-27 Prostate cancer; CESC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg24531977 chr5:56204891 C5orf35 -0.88 -10.96 -0.56 2.74e-23 Initial pursuit acceleration; CESC cis rs6496667 0.533 rs2589949 chr15:90955015 C/T cg22089800 chr15:90895588 ZNF774 0.43 5.57 0.32 6.25e-8 Rheumatoid arthritis; CESC cis rs7829975 0.593 rs2979241 chr8:8303353 G/C cg06636001 chr8:8085503 FLJ10661 0.53 6.99 0.39 2.22e-11 Mood instability; CESC cis rs7927771 0.839 rs3817334 chr11:47650993 C/T cg05585544 chr11:47624801 NA -0.44 -6.99 -0.39 2.17e-11 Subjective well-being; CESC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.88 0.34 1.23e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11098499 0.754 rs1546503 chr4:120241167 T/C cg09307838 chr4:120376055 NA 0.79 10.65 0.55 2.89e-22 Corneal astigmatism; CESC cis rs4820294 1.000 rs713835 chr22:38064650 C/T cg21798802 chr22:38057573 PDXP 0.46 7.99 0.44 4.16e-14 Fat distribution (HIV); CESC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg27211696 chr2:191398769 TMEM194B 0.54 7.75 0.43 1.91e-13 Pulse pressure; CESC cis rs9916302 0.904 rs10491128 chr17:37551988 G/A cg15445000 chr17:37608096 MED1 -0.4 -6.35 -0.36 9.2e-10 Glomerular filtration rate (creatinine); CESC cis rs6570726 0.846 rs441575 chr6:145849205 A/C cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.96e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9584850 0.834 rs7985565 chr13:99113471 C/G cg20750642 chr13:99100586 FARP1 -0.38 -5.92 -0.34 9.73e-9 Neuroticism; CESC cis rs9287719 0.967 rs10929682 chr2:10732189 C/A cg02196655 chr2:10830764 NOL10 -0.36 -5.57 -0.32 6.1e-8 Prostate cancer; CESC cis rs3806843 0.705 rs2530230 chr5:140088131 G/A cg26395211 chr5:140044315 WDR55 0.48 6.1 0.35 3.71e-9 Depressive symptoms (multi-trait analysis); CESC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg17724175 chr1:150552817 MCL1 0.41 6.3 0.36 1.24e-9 Melanoma; CESC cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg19077165 chr18:44547161 KATNAL2 -0.61 -9.19 -0.49 1.2e-17 Personality dimensions; CESC cis rs763121 0.853 rs2235230 chr22:39124467 A/G cg06544989 chr22:39130855 UNC84B -0.48 -7.94 -0.44 5.83e-14 Menopause (age at onset); CESC cis rs1395 0.744 rs1975384 chr2:27542041 C/T cg22903471 chr2:27725779 GCKR -0.47 -5.67 -0.33 3.72e-8 Blood metabolite levels; CESC cis rs6061231 0.556 rs6121571 chr20:60977323 T/G cg15674680 chr20:60982522 CABLES2 0.51 6.28 0.36 1.37e-9 Colorectal cancer; CESC cis rs897984 0.513 rs17839568 chr16:31099783 T/C cg02466173 chr16:30829666 NA -0.4 -6.79 -0.38 7.45e-11 Dementia with Lewy bodies; CESC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg04369109 chr6:150039330 LATS1 -0.47 -6.36 -0.36 9.04e-10 Lung cancer; CESC cis rs1348850 0.567 rs1527401 chr2:178522104 C/T cg22681709 chr2:178499509 PDE11A -0.5 -8.12 -0.45 1.78e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1003719 0.788 rs1155787 chr21:38448069 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.64 0.47 5.56e-16 Eye color traits; CESC cis rs1707322 0.721 rs10789470 chr1:46158331 T/G cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs57083693 0.518 rs7315815 chr12:101747517 C/G cg22051763 chr12:101673672 UTP20 -0.44 -5.52 -0.32 8.05e-8 Alcohol dependence (age at onset); CESC cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2486288 0.656 rs12899058 chr15:45547324 G/A cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.54 -0.37 3.21e-10 Glomerular filtration rate; CESC cis rs2439831 0.867 rs2412779 chr15:43655927 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.93 11.25 0.57 2.98e-24 Lung cancer in ever smokers; CESC cis rs8180040 0.966 rs17476234 chr3:47326298 G/A cg27129171 chr3:47204927 SETD2 -0.66 -10.07 -0.53 2.14e-20 Colorectal cancer; CESC cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg08822215 chr16:89438651 ANKRD11 0.41 6.5 0.37 3.94e-10 Multiple myeloma (IgH translocation); CESC cis rs9614461 0.826 rs9614649 chr22:45746097 C/A cg15911859 chr22:45810043 RIBC2;SMC1B 0.68 7.52 0.42 8.52e-13 Tonsillectomy; CESC cis rs7107174 0.892 rs10431155 chr11:78121978 T/C cg02023728 chr11:77925099 USP35 0.43 5.5 0.32 8.8e-8 Testicular germ cell tumor; CESC trans rs1814175 0.645 rs1851869 chr11:49960552 T/C cg15704280 chr7:45808275 SEPT13 -1.01 -19.0 -0.76 2.27e-51 Height; CESC cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg03433033 chr1:76189801 ACADM 0.68 8.14 0.45 1.54e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg11301795 chr4:187892539 NA -0.75 -12.33 -0.6 6.74e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs4253772 0.550 rs55926596 chr22:46682955 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 5.24 0.31 3.26e-7 LDL cholesterol;Cholesterol, total; CESC cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg25019033 chr10:957182 NA -0.65 -6.31 -0.36 1.18e-9 Eosinophil percentage of granulocytes; CESC trans rs10776614 0.799 rs7071095 chr10:49763818 A/C cg19218067 chr2:181235115 NA 0.5 6.1 0.35 3.7e-9 Self-employment; CESC cis rs7605827 0.897 rs6753675 chr2:15539706 C/T cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs11098499 0.954 rs12508504 chr4:120410607 A/C cg09307838 chr4:120376055 NA 0.93 13.81 0.65 4.64e-33 Corneal astigmatism; CESC cis rs10823500 0.777 rs2184335 chr10:72006891 C/T cg02100629 chr10:71892760 AIFM2 -0.37 -5.71 -0.33 3.03e-8 Blood protein levels; CESC cis rs10129255 0.957 rs12589190 chr14:107191316 C/T cg23076370 chr14:107095027 NA -0.47 -5.98 -0.34 7.21e-9 Kawasaki disease; CESC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg11168104 chr5:1857477 NA -0.36 -5.24 -0.31 3.29e-7 Cardiovascular disease risk factors; CESC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.54 -6.97 -0.39 2.56e-11 Tuberculosis; CESC cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg19077165 chr18:44547161 KATNAL2 0.52 7.41 0.41 1.74e-12 Personality dimensions; CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg15779458 chr2:233415951 TIGD1;EIF4E2 0.55 6.2 0.36 2.12e-9 Endometrial cancer; CESC cis rs713587 0.646 rs2384061 chr2:25135620 C/T cg01884057 chr2:25150051 NA 0.29 5.54 0.32 7.2e-8 Body mass index in non-asthmatics; CESC cis rs17001868 0.568 rs742140 chr22:40781586 G/A cg07138101 chr22:40742427 ADSL 0.57 5.55 0.32 7.07e-8 Mammographic density (dense area); CESC cis rs5769765 1.000 rs768619 chr22:50287266 C/T cg26441486 chr22:50317300 CRELD2 0.38 5.37 0.31 1.77e-7 Schizophrenia; CESC cis rs6433857 0.594 rs34526919 chr2:181522678 T/A cg23363182 chr2:181467187 NA -0.46 -6.16 -0.35 2.73e-9 Body mass index; CESC cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 13.01 0.62 3.06e-30 Platelet count; CESC cis rs4423214 0.559 rs10898203 chr11:71203436 C/T cg05163923 chr11:71159392 DHCR7 -0.66 -6.59 -0.38 2.38e-10 Vitamin D levels; CESC cis rs367615 0.704 rs72804385 chr5:108848143 T/C cg17395555 chr5:108820864 NA 0.61 10.98 0.56 2.33e-23 Colorectal cancer (SNP x SNP interaction); CESC cis rs739401 0.611 rs450817 chr11:3056712 A/G cg08508325 chr11:3079039 CARS -0.56 -11.1 -0.56 9.17e-24 Longevity; CESC cis rs9291683 0.610 rs993172 chr4:10324361 G/T cg11266682 chr4:10021025 SLC2A9 0.48 8.34 0.46 4.14e-15 Bone mineral density; CESC cis rs8070740 0.841 rs2189337 chr17:5326178 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.44 0.37 5.73e-10 Menopause (age at onset); CESC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg13395646 chr4:1353034 KIAA1530 -0.49 -6.22 -0.36 1.88e-9 Obesity-related traits; CESC cis rs10411936 0.712 rs3810198 chr19:16601194 C/T cg10248733 chr19:16607483 C19orf44;CALR3 0.58 6.83 0.39 5.83e-11 White blood cell count;Multiple sclerosis; CESC cis rs12956009 0.583 rs7240132 chr18:44858634 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -6.07 -0.35 4.44e-9 Educational attainment (years of education); CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg08946332 chr17:6899888 ALOX12 0.45 6.52 0.37 3.51e-10 Tonsillectomy; CESC cis rs1003719 0.628 rs2835635 chr21:38528866 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.56 -7.33 -0.41 2.73e-12 Eye color traits; CESC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.43 5.27 0.31 2.76e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9303401 0.703 rs8072182 chr17:57211213 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.59 7.64 0.42 3.96e-13 Cognitive test performance; CESC cis rs2011503 0.941 rs10422893 chr19:19372185 G/C cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.53 0.32 7.55e-8 Bipolar disorder; CESC cis rs561341 0.505 rs548298 chr17:30297494 C/A cg12193833 chr17:30244370 NA -0.59 -6.02 -0.35 5.78e-9 Hip circumference adjusted for BMI; CESC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg19163074 chr7:65112434 INTS4L2 0.46 5.57 0.32 6.37e-8 Aortic root size; CESC cis rs7267979 1.000 rs6050632 chr20:25432601 A/G cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.4e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg10691866 chr7:65817282 TPST1 0.31 5.23 0.31 3.43e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13270404 chr8:99129495 POP1;HRSP12 0.62 7.04 0.4 1.69e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.544 rs35160902 chr4:98974690 A/T cg03467027 chr4:99064603 C4orf37 0.42 5.27 0.31 2.86e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24343413 chr1:151735844 OAZ3;MRPL9 0.56 7.12 0.4 1.01e-11 Gut microbiome composition (summer); CESC cis rs3820928 0.605 rs2228555 chr2:227872995 C/T cg11843606 chr2:227700838 RHBDD1 0.49 6.82 0.39 6.22e-11 Pulmonary function; CESC cis rs9894429 1.000 rs7222241 chr17:79574714 C/G cg21984481 chr17:79567631 NPLOC4 -0.5 -8.18 -0.45 1.2e-14 Eye color traits; CESC cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7772486 0.902 rs2144476 chr6:146322484 G/A cg05347473 chr6:146136440 FBXO30 0.48 6.48 0.37 4.33e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10392 0.571 rs6015982 chr20:37534369 C/T cg27552599 chr20:37590471 DHX35 0.39 5.65 0.33 4.24e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC trans rs35110281 0.574 rs1836856 chr21:44964638 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 7.07 0.4 1.36e-11 Mean corpuscular volume; CESC cis rs12476592 0.602 rs7571325 chr2:63785914 G/A cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs7210086 0.948 rs72849449 chr17:70638505 C/T cg04206342 chr17:70636940 NA -0.35 -6.01 -0.35 6.05e-9 Ulcerative colitis; CESC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg14393609 chr7:65229607 NA -0.41 -5.33 -0.31 2.08e-7 Aortic root size; CESC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg19077165 chr18:44547161 KATNAL2 -0.62 -9.37 -0.5 3.26e-18 Personality dimensions; CESC cis rs61776719 0.500 rs11210866 chr1:38449565 T/C cg17077180 chr1:38461687 NA 0.47 7.13 0.4 9.57e-12 Coronary artery disease; CESC cis rs3733585 0.699 rs28837683 chr4:9959808 C/T cg02734326 chr4:10020555 SLC2A9 -0.44 -6.11 -0.35 3.58e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg11890956 chr21:40555474 PSMG1 -0.62 -8.49 -0.46 1.52e-15 Menarche (age at onset); CESC cis rs9549367 0.713 rs9549681 chr13:113829873 T/C cg00898013 chr13:113819073 PROZ -0.55 -7.51 -0.42 8.85e-13 Platelet distribution width; CESC cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.75 9.56 0.51 8.73e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs11098499 0.954 rs3733523 chr4:120423719 C/T cg09307838 chr4:120376055 NA 0.93 13.08 0.63 1.67e-30 Corneal astigmatism; CESC trans rs4919087 1.000 rs10786329 chr10:99074621 G/A cg09150807 chr12:131568764 GPR133 -0.37 -6.07 -0.35 4.41e-9 Monocyte count; CESC cis rs2306032 0.669 rs10838622 chr11:46856536 T/C cg25783544 chr11:47291846 MADD -0.4 -5.2 -0.3 4.09e-7 Total body bone mineral density; CESC cis rs35146811 0.586 rs1076237 chr7:99585441 A/C cg14163444 chr7:99595348 NA -0.39 -5.24 -0.31 3.33e-7 Coronary artery disease; CESC cis rs6121246 1.000 rs6121246 chr20:30433352 C/T cg13852791 chr20:30311386 BCL2L1 0.76 7.67 0.43 3.38e-13 Mean corpuscular hemoglobin; CESC trans rs561341 1.000 rs72823785 chr17:30273784 C/T cg27661571 chr11:113659931 NA -0.83 -7.62 -0.42 4.42e-13 Hip circumference adjusted for BMI; CESC cis rs6120849 0.754 rs6120797 chr20:33606002 G/A cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs1153858 1.000 rs1153849 chr15:45695695 G/A cg10760299 chr15:45669010 GATM 0.37 5.14 0.3 5.42e-7 Homoarginine levels; CESC cis rs12540874 0.728 rs3807563 chr7:50566390 C/T cg18232548 chr7:50535776 DDC -0.41 -5.49 -0.32 9.25e-8 Systemic sclerosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16216227 chr4:174293382 SAP30 -0.41 -6.04 -0.35 5.19e-9 Gut microbiota (bacterial taxa); CESC cis rs7089973 0.646 rs35453961 chr10:116638166 T/C cg25233709 chr10:116636983 FAM160B1 0.4 6.3 0.36 1.23e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1144333 1.000 rs76192904 chr1:76359995 C/T cg22875332 chr1:76189707 ACADM 0.57 5.62 0.33 4.83e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg16680214 chr1:154839983 KCNN3 -0.44 -6.76 -0.38 8.73e-11 Prostate cancer; CESC cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg21918786 chr6:109611834 NA -0.4 -6.05 -0.35 5.03e-9 Reticulocyte fraction of red cells; CESC cis rs7551222 0.752 rs4252685 chr1:204496856 C/A cg20240347 chr1:204465584 NA -0.28 -5.74 -0.33 2.59e-8 Schizophrenia; CESC cis rs4722166 0.630 rs12700391 chr7:22777327 C/A cg05472934 chr7:22766657 IL6 0.87 10.94 0.56 3.06e-23 Lung cancer; CESC cis rs12476592 0.602 rs6546009 chr2:63745742 G/C cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs7020830 0.571 rs7031314 chr9:37376122 A/T cg14294708 chr9:37120828 ZCCHC7 -0.99 -12.35 -0.6 5.66e-28 Schizophrenia; CESC cis rs7208859 0.623 rs11657662 chr17:29076347 A/G cg19761014 chr17:28927070 LRRC37B2 -0.83 -6.55 -0.37 2.95e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -6.78 -0.38 7.61e-11 Bipolar disorder; CESC cis rs11955398 0.625 rs34395679 chr5:59954716 A/G cg02684056 chr5:59996105 DEPDC1B 0.4 5.09 0.3 6.86e-7 Intelligence (multi-trait analysis); CESC cis rs10206020 0.921 rs6605278 chr2:1547230 C/T cg01028140 chr2:1542097 TPO -0.47 -5.93 -0.34 9.62e-9 IgG glycosylation; CESC cis rs2952156 0.652 rs11869286 chr17:37813856 C/G cg20243544 chr17:37824526 PNMT 0.68 9.31 0.5 5.04e-18 Asthma; CESC cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.95e-9 Extrinsic epigenetic age acceleration; CESC cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg03433033 chr1:76189801 ACADM -0.58 -5.97 -0.34 7.72e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6545883 0.894 rs12997538 chr2:61564249 A/C cg15711740 chr2:61764176 XPO1 0.44 5.46 0.32 1.07e-7 Tuberculosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23709988 chr14:23772096 PPP1R3E 0.57 6.58 0.37 2.43e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs9485024 chr6:146142487 A/G cg23711669 chr6:146136114 FBXO30 -0.87 -11.97 -0.59 1.09e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs62064224 0.714 rs4795692 chr17:30636688 G/T cg18200150 chr17:30822561 MYO1D 0.4 5.34 0.31 1.95e-7 Schizophrenia; CESC cis rs8005677 1.000 rs2295683 chr14:23388382 A/C cg25600027 chr14:23388339 RBM23 -0.43 -5.33 -0.31 2.08e-7 Cognitive ability (multi-trait analysis); CESC cis rs6500602 0.647 rs1659497 chr16:4594635 G/A cg08645402 chr16:4508243 NA -0.46 -7.21 -0.4 5.84e-12 Schizophrenia; CESC cis rs3820928 0.605 rs2228555 chr2:227872995 C/T cg05526886 chr2:227700861 RHBDD1 0.48 6.38 0.37 7.71e-10 Pulmonary function; CESC cis rs754466 0.606 rs55854323 chr10:79589904 C/T cg17075019 chr10:79541650 NA -0.88 -14.05 -0.65 6.89e-34 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2404602 0.692 rs4641709 chr15:77047736 C/T cg26408565 chr15:76604113 ETFA 0.39 5.74 0.33 2.57e-8 Blood metabolite levels; CESC cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg03467027 chr4:99064603 C4orf37 0.45 5.8 0.34 1.87e-8 Colonoscopy-negative controls vs population controls; CESC cis rs3092073 0.669 rs11697323 chr20:44551579 C/T cg17986701 chr20:44574422 PCIF1 0.35 5.12 0.3 5.78e-7 Intelligence (multi-trait analysis); CESC cis rs754466 0.914 rs12218917 chr10:79701479 C/T cg17075019 chr10:79541650 NA -0.68 -8.29 -0.45 5.91e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6088590 0.965 rs6087639 chr20:33443866 G/A cg08999081 chr20:33150536 PIGU 0.58 8.82 0.48 1.57e-16 Coronary artery disease; CESC cis rs8141529 0.702 rs469992 chr22:29314899 T/C cg02153584 chr22:29168773 CCDC117 -0.57 -7.22 -0.41 5.58e-12 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05342987 chr14:59655273 DAAM1 0.62 7.16 0.4 7.84e-12 Gut microbiome composition (summer); CESC cis rs7301826 0.651 rs7295705 chr12:131301885 C/T cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC cis rs4595586 0.525 rs1878227 chr12:39355719 A/T cg26384229 chr12:38710491 ALG10B 0.63 8.79 0.48 1.9e-16 Morning vs. evening chronotype; CESC cis rs798554 0.704 rs798531 chr7:2770067 G/C cg13628971 chr7:2884303 GNA12 0.41 5.39 0.31 1.54e-7 Height; CESC trans rs1814175 0.935 rs11040463 chr11:49685574 C/T cg03929089 chr4:120376271 NA -0.87 -13.35 -0.63 1.97e-31 Height; CESC cis rs6032067 0.929 rs35869085 chr20:43805134 G/C cg10761708 chr20:43804764 PI3 0.53 6.37 0.36 8.25e-10 Blood protein levels; CESC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg08888203 chr3:10149979 C3orf24 0.45 5.91 0.34 1.06e-8 Alzheimer's disease; CESC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg18252515 chr7:66147081 NA -0.43 -5.62 -0.33 4.9e-8 Aortic root size; CESC cis rs9399137 0.507 rs11759077 chr6:135381351 A/G cg22676075 chr6:135203613 NA 0.53 7.01 0.4 1.95e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg18402987 chr7:1209562 NA 0.75 7.51 0.42 9.28e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1707322 0.752 rs28550303 chr1:46188914 G/T cg06784218 chr1:46089804 CCDC17 0.42 7.26 0.41 4.34e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs807669 0.903 rs756651 chr22:19179367 T/C cg02655711 chr22:19163373 SLC25A1 0.97 14.93 0.68 5.37e-37 Metabolite levels; CESC cis rs10178094 0.933 rs7423892 chr2:161329644 C/T cg03641300 chr2:160917029 PLA2R1 0.4 5.83 0.34 1.64e-8 White blood cell count; CESC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg27165867 chr14:105738592 BRF1 0.49 5.29 0.31 2.59e-7 Mean platelet volume;Platelet distribution width; CESC cis rs11608355 0.545 rs36094325 chr12:109911542 A/T cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs10129255 0.957 rs10142859 chr14:107190475 A/G cg07958169 chr14:107095056 NA -0.39 -5.3 -0.31 2.47e-7 Kawasaki disease; CESC cis rs7044106 0.537 rs10739573 chr9:123489818 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.74 9.51 0.5 1.21e-18 Hip circumference adjusted for BMI; CESC cis rs6940638 0.513 rs4424065 chr6:27036456 C/T cg12292205 chr6:26970375 C6orf41 -0.46 -7.16 -0.4 8.09e-12 Intelligence (multi-trait analysis); CESC cis rs208520 0.690 rs207096 chr6:66797287 T/C cg07460842 chr6:66804631 NA -1.0 -13.43 -0.64 1.05e-31 Exhaled nitric oxide output; CESC cis rs9902453 0.933 rs7216487 chr17:28502642 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 7.48 0.42 1.11e-12 Coffee consumption (cups per day); CESC cis rs6087990 0.806 rs4911108 chr20:31375311 A/G cg13636640 chr20:31349939 DNMT3B 0.81 12.51 0.61 1.56e-28 Ulcerative colitis; CESC cis rs55726902 0.506 rs1006476 chr12:48179347 C/T cg14736327 chr12:48174669 SLC48A1 -0.65 -6.69 -0.38 1.32e-10 Allergic disease (asthma, hay fever or eczema); CESC cis rs72829446 0.530 rs66616380 chr17:7380188 C/A cg02795151 chr17:7402630 POLR2A 0.57 6.07 0.35 4.53e-9 Androgen levels; CESC cis rs11098499 0.909 rs10002083 chr4:120311152 C/T cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs12477438 0.520 rs2516830 chr2:99773702 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.84 0.62 1.16e-29 Chronic sinus infection; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20566420 chr12:122327043 PSMD9 -0.48 -6.89 -0.39 4.16e-11 Gambling; CESC cis rs9303401 0.538 rs10515155 chr17:56481944 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.95 11.32 0.57 1.75e-24 Cognitive test performance; CESC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg13206674 chr6:150067644 NUP43 0.41 5.72 0.33 2.8e-8 Lung cancer; CESC cis rs208520 0.874 rs208485 chr6:66925654 T/C cg07460842 chr6:66804631 NA -0.89 -10.85 -0.55 6.35e-23 Exhaled nitric oxide output; CESC cis rs4141404 0.851 rs9606833 chr22:31750013 T/C cg00478049 chr22:31556069 RNF185 -0.48 -5.13 -0.3 5.71e-7 Paclitaxel-induced neuropathy; CESC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg24562669 chr7:97807699 LMTK2 0.47 6.8 0.39 6.92e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs6752107 1.000 rs35300242 chr2:234168790 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.46 6.32 0.36 1.13e-9 Crohn's disease;Inflammatory bowel disease; CESC trans rs561341 0.609 rs11658984 chr17:30186612 C/T cg20587970 chr11:113659929 NA 0.57 6.96 0.39 2.65e-11 Hip circumference adjusted for BMI; CESC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg17724175 chr1:150552817 MCL1 0.33 5.07 0.3 7.32e-7 Melanoma; CESC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg26338869 chr17:61819248 STRADA -0.69 -9.04 -0.49 3.3e-17 Prudent dietary pattern; CESC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg06074448 chr4:187884817 NA -0.39 -5.52 -0.32 8.02e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs8099014 0.770 rs1135519 chr18:56117145 C/T cg19312305 chr18:56117016 MIR122 -0.26 -5.21 -0.3 3.83e-7 Platelet count; CESC cis rs11190604 1.000 rs2489051 chr10:102351785 C/T cg07080220 chr10:102295463 HIF1AN -0.56 -5.3 -0.31 2.47e-7 Palmitoleic acid (16:1n-7) levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25757740 chr10:72647938 PCBD1 0.56 6.46 0.37 5.07e-10 Gut microbiome composition (summer); CESC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg26818010 chr10:134567672 INPP5A 0.82 10.19 0.53 8.69e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg05564831 chr3:52568323 NT5DC2 0.46 7.22 0.41 5.37e-12 Bipolar disorder; CESC cis rs2180341 0.814 rs7768435 chr6:127737038 A/C cg24812749 chr6:127587940 RNF146 0.84 12.05 0.59 5.93e-27 Breast cancer; CESC cis rs116095464 0.558 rs9654452 chr5:299561 C/T cg10591111 chr5:226296 SDHA -0.53 -6.45 -0.37 5.35e-10 Breast cancer; CESC cis rs6084875 0.733 rs7354668 chr20:4741710 A/C cg05143360 chr20:4741328 NA 0.54 7.31 0.41 3.22e-12 Systemic lupus erythematosus; CESC cis rs73206853 0.764 rs7311376 chr12:110605559 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.62 0.33 4.79e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9325144 0.647 rs61930266 chr12:38922048 A/G cg26384229 chr12:38710491 ALG10B -0.54 -7.53 -0.42 8.01e-13 Morning vs. evening chronotype; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg17492891 chr22:41843204 TOB2 0.48 6.35 0.36 9.56e-10 Weight; CESC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg26314531 chr2:26401878 FAM59B -0.61 -6.94 -0.39 2.97e-11 Gut microbiome composition (summer); CESC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg22800045 chr5:56110881 MAP3K1 0.8 9.58 0.51 7.41e-19 Initial pursuit acceleration; CESC cis rs2797160 0.967 rs2797162 chr6:126011381 G/T cg05901451 chr6:126070800 HEY2 0.45 6.6 0.38 2.19e-10 Endometrial cancer; CESC cis rs8060686 0.641 rs8047119 chr16:68047345 G/C cg26727032 chr16:67993705 SLC12A4 -0.54 -6.15 -0.35 2.78e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs644799 0.526 rs693792 chr11:95622200 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.52 6.63 0.38 1.84e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1801251 1.000 rs2592113 chr2:233669553 C/T cg25237894 chr2:233734115 C2orf82 0.44 7.81 0.43 1.32e-13 Coronary artery disease; CESC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg02398342 chr17:80708632 TBCD;FN3K 0.47 5.69 0.33 3.33e-8 Glycated hemoglobin levels; CESC cis rs2228479 0.850 rs11639906 chr16:89798183 T/C cg04013166 chr16:89971882 TCF25 0.67 5.38 0.31 1.65e-7 Skin colour saturation; CESC cis rs17376456 0.877 rs28637444 chr5:93495548 C/T cg21475434 chr5:93447410 FAM172A 0.9 7.77 0.43 1.68e-13 Diabetic retinopathy; CESC cis rs6893300 0.961 rs113829727 chr5:179191896 C/T cg14593053 chr5:179126677 CANX -0.53 -5.87 -0.34 1.27e-8 Resting heart rate; CESC cis rs6502050 0.734 rs7217625 chr17:80157766 T/C cg23985595 chr17:80112537 CCDC57 -0.39 -6.24 -0.36 1.76e-9 Life satisfaction; CESC cis rs6570726 0.902 rs373321 chr6:145854150 T/A cg05347473 chr6:146136440 FBXO30 0.48 6.44 0.37 5.7e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs920590 0.758 rs35896770 chr8:19665616 G/C cg03894339 chr8:19674705 INTS10 0.68 7.92 0.44 6.52e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs7527798 0.592 rs10863461 chr1:207840776 C/T cg21110645 chr1:207815933 NA -0.32 -5.72 -0.33 2.94e-8 Erythrocyte sedimentation rate; CESC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs2404602 0.698 rs12909656 chr15:76664378 A/T cg23625390 chr15:77176239 SCAPER -0.42 -5.77 -0.33 2.26e-8 Blood metabolite levels; CESC cis rs12464483 0.591 rs4952170 chr2:30885429 G/A cg12454169 chr2:30669597 LCLAT1 0.66 6.88 0.39 4.28e-11 Pre-treatment pain in head and neck squamous cell carcinoma; CESC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg02187348 chr16:89574699 SPG7 0.58 7.67 0.43 3.32e-13 Multiple myeloma (IgH translocation); CESC cis rs3806843 1.000 rs7701755 chr5:140182101 G/T cg26395211 chr5:140044315 WDR55 -0.42 -5.35 -0.31 1.94e-7 Depressive symptoms (multi-trait analysis); CESC cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg12419862 chr22:24373484 LOC391322 0.79 10.34 0.54 2.8e-21 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg23711669 chr6:146136114 FBXO30 -1.0 -15.48 -0.69 6.3e-39 Lobe attachment (rater-scored or self-reported); CESC trans rs66573146 0.634 rs55633489 chr4:6988745 C/A cg07817883 chr1:32538562 TMEM39B 1.14 7.98 0.44 4.51e-14 Granulocyte percentage of myeloid white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17291625 chr16:236080 NA -0.56 -6.46 -0.37 4.88e-10 Gut microbiome composition (summer); CESC cis rs7697216 0.668 rs6553846 chr4:175822759 C/T cg14561282 chr4:175839468 ADAM29 0.47 5.55 0.32 7.01e-8 Breast cancer; CESC cis rs7100689 0.784 rs3120977 chr10:82075324 C/G cg00277334 chr10:82204260 NA -0.59 -7.48 -0.42 1.08e-12 Post bronchodilator FEV1; CESC cis rs8016982 0.657 rs8021125 chr14:81704787 C/T cg01989461 chr14:81687754 GTF2A1 -0.69 -10.66 -0.55 2.53e-22 Schizophrenia; CESC cis rs1707322 0.752 rs11211145 chr1:46108491 A/C cg03146154 chr1:46216737 IPP 0.76 9.75 0.51 2.21e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg04546413 chr19:29218101 NA 0.56 7.79 0.43 1.52e-13 Methadone dose in opioid dependence; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16101257 chr8:146024039 ZNF517 -0.54 -7.16 -0.4 7.99e-12 Fibrinogen levels; CESC cis rs9790314 0.905 rs4518145 chr3:160950030 T/C cg03342759 chr3:160939853 NMD3 -0.47 -6.31 -0.36 1.17e-9 Morning vs. evening chronotype; CESC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg22974920 chr21:40686053 BRWD1 -0.44 -5.29 -0.31 2.51e-7 Cognitive function; CESC cis rs748404 0.588 rs2255410 chr15:43831097 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.85 0.43 1.03e-13 Lung cancer; CESC cis rs57506017 0.585 rs1054169 chr7:12273496 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.17 0.3 4.57e-7 Neuroticism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13369981 chr7:100027501 MEPCE;ZCWPW1 0.45 6.42 0.37 6.34e-10 Gut microbiota (bacterial taxa); CESC cis rs11864453 0.826 rs2074626 chr16:72139184 C/A cg01557791 chr16:72042693 DHODH -0.52 -6.77 -0.38 8.45e-11 Fibrinogen levels; CESC cis rs9291683 0.530 rs4697698 chr4:9942577 C/T cg02734326 chr4:10020555 SLC2A9 0.43 6.35 0.36 9.3e-10 Bone mineral density; CESC cis rs796364 1.000 rs281788 chr2:200783705 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.87 8.44 0.46 2.14e-15 Schizophrenia; CESC cis rs796364 0.951 rs281769 chr2:200809709 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.9 9.29 0.5 5.66e-18 Schizophrenia; CESC cis rs35110281 0.720 rs162372 chr21:44928863 C/T cg21573476 chr21:45109991 RRP1B 0.43 5.93 0.34 9.21e-9 Mean corpuscular volume; CESC cis rs524281 0.861 rs7943911 chr11:65943054 G/A cg14036092 chr11:66035641 RAB1B -0.56 -5.57 -0.32 6.24e-8 Electroencephalogram traits; CESC cis rs7267979 0.586 rs6050445 chr20:25195394 C/T cg08601574 chr20:25228251 PYGB 0.36 5.13 0.3 5.54e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs554111 0.637 rs529162 chr1:21063311 T/A cg04902671 chr1:21058625 SH2D5 -0.43 -5.19 -0.3 4.2e-7 Facial morphology (factor 17, height of vermillion upper lip); CESC cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg05340658 chr4:99064831 C4orf37 0.69 9.2 0.49 1.08e-17 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20781216 chr8:144546287 ZC3H3 0.5 6.6 0.38 2.28e-10 Fibrinogen levels; CESC cis rs1832871 0.643 rs112195967 chr6:158775695 C/T cg07165851 chr6:158734300 TULP4 0.54 5.43 0.32 1.29e-7 Height; CESC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg06453172 chr10:134556979 INPP5A -0.39 -5.03 -0.3 8.95e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg23048001 chr7:2026167 MAD1L1 -0.49 -6.29 -0.36 1.3e-9 Bipolar disorder and schizophrenia; CESC cis rs9644630 0.870 rs4244453 chr8:19359711 G/A cg01280390 chr8:19363452 CSGALNACT1 0.33 5.18 0.3 4.42e-7 Oropharynx cancer; CESC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs4561483 0.801 rs154148 chr16:11956478 T/C cg08843971 chr16:11963173 GSPT1 -0.54 -7.9 -0.44 7.27e-14 Testicular germ cell tumor; CESC cis rs2204008 0.683 rs11519834 chr12:38053575 T/A cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs7903847 0.642 rs1048442 chr10:99160152 A/G cg20016023 chr10:99160130 RRP12 -0.3 -5.2 -0.3 3.91e-7 Granulocyte percentage of myeloid white cells; CESC cis rs4727963 0.811 rs2140853 chr7:122713121 A/T cg03640110 chr7:122635026 TAS2R16 -0.38 -5.89 -0.34 1.18e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs2658782 1.000 rs2658779 chr11:93163137 G/T cg15737290 chr11:93063684 CCDC67 -0.53 -6.69 -0.38 1.28e-10 Pulmonary function decline; CESC trans rs208520 0.690 rs12213561 chr6:66705646 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.6 0.61 7.7e-29 Exhaled nitric oxide output; CESC cis rs7927592 0.871 rs113020558 chr11:68296832 G/A cg20283391 chr11:68216788 NA -0.62 -7.53 -0.42 8.09e-13 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07116015 chr17:27046591 RAB34;SNORD42B;RPL23A -0.46 -6.1 -0.35 3.71e-9 Fibrinogen levels; CESC cis rs7917772 0.503 rs11191328 chr10:104305185 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.31 0.31 2.36e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6893300 0.785 rs17617710 chr5:179206107 G/A cg14593053 chr5:179126677 CANX -0.49 -5.86 -0.34 1.34e-8 Resting heart rate; CESC cis rs1707322 0.752 rs6678444 chr1:46229847 A/G cg05343316 chr1:45956843 TESK2 0.5 6.25 0.36 1.62e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs17027102 chr4:98919221 A/G cg17366294 chr4:99064904 C4orf37 -0.56 -7.83 -0.43 1.21e-13 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC trans rs2727020 0.729 rs10839268 chr11:49380328 G/A cg15704280 chr7:45808275 SEPT13 -0.87 -14.48 -0.66 2.03e-35 Coronary artery disease; CESC cis rs523522 0.962 rs10774549 chr12:120891172 C/T cg27279351 chr12:120934652 DYNLL1 0.67 8.42 0.46 2.35e-15 High light scatter reticulocyte count; CESC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg07701084 chr6:150067640 NUP43 0.45 6.45 0.37 5.26e-10 Lung cancer; CESC cis rs9611565 0.659 rs17367849 chr22:41923644 G/A cg06481639 chr22:41940642 POLR3H -0.59 -6.17 -0.35 2.56e-9 Vitiligo; CESC cis rs9611565 0.877 rs3817999 chr22:41747717 A/G cg06481639 chr22:41940642 POLR3H 0.46 5.37 0.31 1.7e-7 Vitiligo; CESC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg18016565 chr1:150552671 MCL1 0.33 5.15 0.3 5.13e-7 Tonsillectomy; CESC cis rs950169 0.800 rs34302901 chr15:85110943 C/G cg17507749 chr15:85114479 UBE2QP1 0.54 6.31 0.36 1.17e-9 Schizophrenia; CESC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg04553112 chr3:125709451 NA -0.5 -5.68 -0.33 3.57e-8 Blood pressure (smoking interaction); CESC cis rs2455799 0.613 rs2345736 chr3:15824860 T/G cg16303742 chr3:15540471 COLQ -0.38 -5.82 -0.34 1.69e-8 Mean platelet volume; CESC cis rs6456156 0.755 rs4710182 chr6:167514061 G/A cg07741184 chr6:167504864 NA 0.38 6.92 0.39 3.46e-11 Primary biliary cholangitis; CESC cis rs72772090 0.539 rs55773007 chr5:96124918 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.26 -0.31 3.01e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs644799 0.509 rs580181 chr11:95643040 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.49 6.56 0.37 2.85e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.32 0.31 2.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg24642844 chr7:1081250 C7orf50 -0.72 -8.72 -0.47 3.07e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg19077165 chr18:44547161 KATNAL2 0.64 9.56 0.51 8.41e-19 Personality dimensions; CESC cis rs3749237 0.595 rs4855839 chr3:49507847 G/A cg06212747 chr3:49208901 KLHDC8B 0.52 6.9 0.39 3.72e-11 Resting heart rate; CESC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg05552183 chr6:42928497 GNMT 0.79 12.72 0.62 3.08e-29 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7116495 0.786 rs1894003 chr11:71750276 A/G cg26138937 chr11:71823887 C11orf51 -0.78 -6.37 -0.36 8.34e-10 Severe influenza A (H1N1) infection; CESC cis rs11958404 1.000 rs72816531 chr5:157413079 A/G cg05962755 chr5:157440814 NA 0.52 5.95 0.34 8.38e-9 IgG glycosylation; CESC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg27170947 chr2:26402098 FAM59B 0.87 10.16 0.53 1.05e-20 Gut microbiome composition (summer); CESC cis rs9291683 0.588 rs12506364 chr4:10023448 C/T cg11266682 chr4:10021025 SLC2A9 0.7 14.77 0.67 1.92e-36 Bone mineral density; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg23182539 chr10:121355708 TIAL1 0.47 6.36 0.36 8.9e-10 Systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13653153 chr9:130885858 PTGES2 0.56 7.93 0.44 6.26e-14 Fibrinogen levels; CESC cis rs9896933 0.775 rs79299098 chr17:80830944 G/A cg15664640 chr17:80829946 TBCD -0.53 -5.62 -0.33 4.83e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg22920501 chr2:26401640 FAM59B -0.68 -8.18 -0.45 1.21e-14 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs10055405 chr5:265666 C/T cg22857025 chr5:266934 NA -1.28 -18.09 -0.74 3.47e-48 Breast cancer; CESC cis rs6445797 0.632 rs2035798 chr3:56598544 G/A cg13792233 chr3:56591045 CCDC66 0.39 5.08 0.3 7.22e-7 Gastritis; CESC cis rs9916302 0.904 rs2338798 chr17:37547269 T/C cg07936489 chr17:37558343 FBXL20 0.8 11.62 0.58 1.74e-25 Glomerular filtration rate (creatinine); CESC cis rs6088580 0.634 rs6059892 chr20:33105766 A/G cg08999081 chr20:33150536 PIGU 0.65 11.26 0.57 2.65e-24 Glomerular filtration rate (creatinine); CESC cis rs8114671 0.562 rs6088646 chr20:33505937 T/C cg06115741 chr20:33292138 TP53INP2 0.46 5.58 0.32 6.06e-8 Height; CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg17221315 chr6:27791827 HIST1H4J 0.45 5.07 0.3 7.46e-7 Depression; CESC cis rs3126085 0.877 rs12116736 chr1:152167062 C/T cg26876637 chr1:152193138 HRNR 0.44 5.04 0.3 8.68e-7 Atopic dermatitis; CESC cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.42 5.22 0.31 3.55e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg26314531 chr2:26401878 FAM59B -0.62 -6.99 -0.39 2.29e-11 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.87 0.34 1.3e-8 Tonsillectomy; CESC cis rs7937682 0.921 rs688354 chr11:111438762 A/G cg22437258 chr11:111473054 SIK2 0.67 8.51 0.46 1.33e-15 Primary sclerosing cholangitis; CESC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg15145296 chr3:125709740 NA -0.49 -5.27 -0.31 2.78e-7 Blood pressure (smoking interaction); CESC cis rs9309473 0.950 rs1052162 chr2:73829372 A/G cg20560298 chr2:73613845 ALMS1 0.45 6.11 0.35 3.49e-9 Metabolite levels; CESC cis rs7772486 0.875 rs854145 chr6:146349650 C/T cg23711669 chr6:146136114 FBXO30 0.83 12.1 0.6 3.95e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs60843830 1.000 rs62114497 chr2:214837 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.86 11.23 0.57 3.36e-24 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg14393609 chr7:65229607 NA -0.48 -6.52 -0.37 3.63e-10 Aortic root size; CESC trans rs116095464 0.558 rs10065239 chr5:275288 C/T cg00938859 chr5:1591904 SDHAP3 0.71 6.55 0.37 2.92e-10 Breast cancer; CESC trans rs60843830 1.000 rs3791223 chr2:222336 T/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 8.23 0.45 8.51e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs60843830 1.000 rs4497901 chr2:239969 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.78 10.2 0.53 7.83e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs6565180 0.962 rs11642676 chr16:30371655 C/G cg17640201 chr16:30407289 ZNF48 -0.93 -13.46 -0.64 8.1e-32 Tonsillectomy; CESC cis rs9291683 0.655 rs35750364 chr4:10049049 T/C cg11266682 chr4:10021025 SLC2A9 0.68 13.42 0.64 1.11e-31 Bone mineral density; CESC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg18404041 chr3:52824283 ITIH1 -0.38 -6.45 -0.37 5.31e-10 Electroencephalogram traits; CESC cis rs4629180 0.675 rs908132 chr2:102093096 A/G cg04415270 chr2:102091202 RFX8 -0.32 -5.46 -0.32 1.09e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs12410462 0.581 rs112572966 chr1:227553905 C/T cg04117972 chr1:227635322 NA 0.65 5.65 0.33 4.14e-8 Major depressive disorder; CESC cis rs7267979 1.000 rs11087520 chr20:25436827 C/T cg08601574 chr20:25228251 PYGB 0.37 5.28 0.31 2.73e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg05457628 chr5:178986728 RUFY1 0.43 5.97 0.34 7.53e-9 Lung cancer; CESC trans rs9325144 0.600 rs10748442 chr12:38732939 A/T cg23762105 chr12:34175262 ALG10 -0.45 -6.02 -0.35 5.64e-9 Morning vs. evening chronotype; CESC cis rs2415984 0.622 rs61993305 chr14:46950955 C/T cg14871534 chr14:47121158 RPL10L -0.38 -5.73 -0.33 2.72e-8 Number of children ever born; CESC cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg06544989 chr22:39130855 UNC84B -0.5 -8.78 -0.47 2.02e-16 Menopause (age at onset); CESC cis rs34779708 0.733 rs3936502 chr10:35549218 C/T cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs208520 0.690 rs9345764 chr6:66820597 C/T cg07460842 chr6:66804631 NA -1.01 -13.53 -0.64 4.61e-32 Exhaled nitric oxide output; CESC cis rs2228479 0.867 rs62052189 chr16:89975555 G/C cg04013166 chr16:89971882 TCF25 0.7 6.91 0.39 3.7e-11 Skin colour saturation; CESC trans rs7615952 0.641 rs12491577 chr3:125731131 C/T cg07211511 chr3:129823064 LOC729375 -0.54 -6.15 -0.35 2.84e-9 Blood pressure (smoking interaction); CESC cis rs7542091 0.704 rs12022221 chr1:210046178 A/C cg23283495 chr1:209979779 IRF6 0.35 5.76 0.33 2.29e-8 Monobrow; CESC cis rs10782582 0.593 rs6704444 chr1:76205108 T/C cg10523679 chr1:76189770 ACADM -0.49 -5.78 -0.33 2.06e-8 Daytime sleep phenotypes; CESC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg24881330 chr22:46731750 TRMU 0.86 7.93 0.44 6.15e-14 LDL cholesterol;Cholesterol, total; CESC cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg20503657 chr10:835505 NA 0.71 6.72 0.38 1.12e-10 Eosinophil percentage of granulocytes; CESC cis rs4304924 0.500 rs9601109 chr13:79220114 A/G cg07926092 chr13:79233506 RNF219 0.61 6.68 0.38 1.43e-10 Large artery stroke; CESC cis rs11785400 0.963 rs9771845 chr8:143726577 C/G cg24634471 chr8:143751801 JRK 0.45 5.95 0.34 8.62e-9 Schizophrenia; CESC cis rs3096299 0.967 rs28644774 chr16:89472181 G/C cg08392591 chr16:89556376 ANKRD11 0.39 5.1 0.3 6.52e-7 Multiple myeloma (IgH translocation); CESC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg24675658 chr1:53192096 ZYG11B 0.53 6.73 0.38 1.04e-10 Monocyte count; CESC cis rs400736 0.729 rs2493216 chr1:8008366 C/A cg25007680 chr1:8021821 PARK7 -0.59 -8.21 -0.45 9.51e-15 Response to antidepressants and depression; CESC cis rs7264396 0.561 rs6060750 chr20:34596371 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.46 5.21 0.3 3.76e-7 Total cholesterol levels; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg02493798 chr17:6899577 ALOX12 0.42 7.48 0.42 1.07e-12 Tonsillectomy; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg09737314 chr17:6899359 ALOX12 0.45 7.71 0.43 2.6e-13 Tonsillectomy; CESC cis rs4919694 1.000 rs11191473 chr10:104710710 C/G cg04362960 chr10:104952993 NT5C2 0.78 6.79 0.38 7.53e-11 Arsenic metabolism; CESC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg19592336 chr6:28129416 ZNF389 0.52 6.77 0.38 8.17e-11 Parkinson's disease; CESC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.58 7.43 0.42 1.52e-12 Bipolar disorder; CESC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.69 -0.33 3.28e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7542091 0.635 rs7550733 chr1:210044968 G/A cg25204440 chr1:209979598 IRF6 0.37 5.1 0.3 6.55e-7 Monobrow; CESC trans rs9951602 0.512 rs9946120 chr18:76654548 A/T cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Depression; CESC cis rs6032067 0.777 rs13042694 chr20:43799368 G/A cg11264863 chr20:43835661 SEMG1 0.5 5.41 0.32 1.42e-7 Blood protein levels; CESC cis rs2230307 0.536 rs581097 chr1:100515920 C/T cg24955406 chr1:100503596 HIAT1 0.56 5.47 0.32 1.06e-7 Carotid intima media thickness; CESC cis rs9309711 0.922 rs13385119 chr2:3484521 G/A cg10845886 chr2:3471009 TTC15 -0.87 -12.1 -0.6 3.91e-27 Neurofibrillary tangles; CESC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg06873352 chr17:61820015 STRADA 0.73 12.98 0.62 3.9e-30 Prudent dietary pattern; CESC cis rs6060717 0.536 rs6060683 chr20:34507921 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.61 0.33 4.97e-8 Hip circumference adjusted for BMI; CESC trans rs10100465 0.596 rs218009 chr8:118716275 A/G cg00607566 chr17:45726993 KPNB1 0.62 6.0 0.35 6.47e-9 Leprosy; CESC cis rs2797160 1.000 rs2747725 chr6:126012397 A/C cg05901451 chr6:126070800 HEY2 0.51 6.47 0.37 4.58e-10 Endometrial cancer; CESC cis rs734999 0.545 rs41300092 chr1:2537838 C/T cg20673091 chr1:2541236 MMEL1 0.46 7.59 0.42 5.5e-13 Ulcerative colitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12427896 chr2:111880694 BCL2L11 0.51 6.7 0.38 1.25e-10 Gut microbiota (bacterial taxa); CESC cis rs854765 0.583 rs4553680 chr17:17857722 A/G cg16928487 chr17:17741425 SREBF1 -0.6 -10.08 -0.53 1.98e-20 Total body bone mineral density; CESC cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg02487422 chr3:49467188 NICN1 0.44 5.49 0.32 9.36e-8 Parkinson's disease; CESC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg05890377 chr2:74357713 NA -0.56 -7.07 -0.4 1.39e-11 Gestational age at birth (maternal effect); CESC cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg18904891 chr8:8559673 CLDN23 0.69 7.99 0.44 4.17e-14 Obesity-related traits; CESC cis rs6964587 1.000 rs10234434 chr7:91673308 A/T cg17063962 chr7:91808500 NA 0.6 8.31 0.45 5.05e-15 Breast cancer; CESC cis rs9309473 0.607 rs1403412 chr2:73598092 T/C cg20560298 chr2:73613845 ALMS1 -0.46 -6.55 -0.37 3.03e-10 Metabolite levels; CESC cis rs7208859 0.623 rs55638872 chr17:29149552 G/C cg14008862 chr17:28927542 LRRC37B2 0.66 5.21 0.3 3.84e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11098499 0.909 rs1546504 chr4:120241179 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.76 0.51 2.07e-19 Corneal astigmatism; CESC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg06108461 chr20:60628389 TAF4 0.48 5.89 0.34 1.16e-8 Obesity-related traits; CESC cis rs6582630 0.679 rs10785514 chr12:38573689 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.84 0.39 5.33e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg00409905 chr10:38381863 ZNF37A -0.45 -6.04 -0.35 5.25e-9 Extrinsic epigenetic age acceleration; CESC trans rs561341 1.000 rs72823787 chr17:30283809 A/T cg27661571 chr11:113659931 NA -0.86 -7.96 -0.44 5.05e-14 Hip circumference adjusted for BMI; CESC cis rs798554 0.660 rs798480 chr7:2805597 G/T cg19717773 chr7:2847554 GNA12 -0.55 -8.46 -0.46 1.84e-15 Height; CESC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg06873352 chr17:61820015 STRADA 0.72 12.56 0.61 1.02e-28 Prudent dietary pattern; CESC cis rs9611565 0.532 rs4401299 chr22:42156517 A/G cg03806693 chr22:41940476 POLR3H 0.79 9.68 0.51 3.55e-19 Vitiligo; CESC cis rs8072100 0.713 rs57427906 chr17:45494014 G/A cg25173405 chr17:45401733 C17orf57 -0.43 -5.43 -0.32 1.26e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9325144 0.577 rs10876008 chr12:39126750 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.14 -0.4 8.72e-12 Morning vs. evening chronotype; CESC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 12.51 0.61 1.61e-28 Alzheimer's disease; CESC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg06634786 chr22:41940651 POLR3H 0.71 7.03 0.4 1.75e-11 Vitiligo; CESC cis rs8060686 0.858 rs1476306 chr16:67973171 C/T cg26727032 chr16:67993705 SLC12A4 -0.64 -9.19 -0.49 1.22e-17 HDL cholesterol;Metabolic syndrome; CESC cis rs1316952 0.831 rs74624536 chr12:124393076 T/G cg00084347 chr12:124393913 DNAH10 0.41 5.68 0.33 3.56e-8 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs1801251 0.778 rs812383 chr2:233737132 C/A cg08000102 chr2:233561755 GIGYF2 -0.59 -8.12 -0.45 1.78e-14 Coronary artery disease; CESC cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg18351406 chr4:77819688 ANKRD56 0.53 6.69 0.38 1.28e-10 Emphysema distribution in smoking; CESC cis rs61776719 0.520 rs11485595 chr1:38411350 C/T cg04673462 chr1:38461896 NA 0.38 5.88 0.34 1.24e-8 Coronary artery disease; CESC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg03806693 chr22:41940476 POLR3H 1.19 14.07 0.65 6.09e-34 Cannabis dependence symptom count; CESC cis rs992157 0.560 rs12992937 chr2:219087072 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.57 -7.45 -0.42 1.29e-12 Colorectal cancer; CESC trans rs2472476 0.900 rs10991370 chr9:107518918 C/G cg14553338 chr2:66689807 MEIS1 0.42 6.17 0.35 2.61e-9 Obesity-related traits; CESC cis rs4253772 1.000 rs11705483 chr22:46630544 C/A cg18190219 chr22:46762943 CELSR1 -0.61 -5.84 -0.34 1.52e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6674176 0.628 rs7556565 chr1:44416090 C/T cg12908607 chr1:44402522 ARTN -0.46 -6.64 -0.38 1.75e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs11690935 0.731 rs10930491 chr2:172569824 A/G cg13550731 chr2:172543902 DYNC1I2 0.58 8.06 0.44 2.69e-14 Schizophrenia; CESC cis rs875971 0.867 rs13227219 chr7:65844062 T/A cg12463550 chr7:65579703 CRCP 0.56 6.98 0.39 2.33e-11 Aortic root size; CESC cis rs7223966 1.000 rs7220821 chr17:61704147 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.5 0.42 9.63e-13 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs644799 1.000 rs580255 chr11:95577929 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.56 6.72 0.38 1.11e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1348850 0.874 rs2166558 chr2:178373652 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.88 12.62 0.61 6.78e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs62229266 0.740 rs2835233 chr21:37393582 A/G cg12218747 chr21:37451666 NA -0.4 -5.71 -0.33 3.01e-8 Mitral valve prolapse; CESC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.81 0.39 6.56e-11 Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16116313 chr12:122255002 SETD1B 0.53 7.37 0.41 2.2e-12 Fibrinogen levels; CESC cis rs4423214 0.650 rs4245442 chr11:71220909 T/C cg24826892 chr11:71159390 DHCR7 0.55 6.12 0.35 3.26e-9 Vitamin D levels; CESC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg04369109 chr6:150039330 LATS1 -0.39 -5.28 -0.31 2.71e-7 Lung cancer; CESC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg18016565 chr1:150552671 MCL1 0.35 5.08 0.3 7.01e-7 Melanoma; CESC cis rs265548 0.646 rs36689 chr19:17910639 A/G cg21960279 chr19:17905606 B3GNT3 0.46 6.82 0.39 6.07e-11 Tumor biomarkers; CESC cis rs2486288 0.656 rs11629858 chr15:45547114 T/C cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.5 -0.37 4.05e-10 Glomerular filtration rate; CESC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg01341218 chr17:43662625 NA -0.58 -7.76 -0.43 1.87e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22187094 chr15:89878452 POLG -0.58 -6.28 -0.36 1.42e-9 Gut microbiome composition (summer); CESC cis rs727563 0.565 rs132774 chr22:42031953 C/G cg06634786 chr22:41940651 POLR3H -0.47 -5.31 -0.31 2.33e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs798554 0.704 rs798513 chr7:2782493 C/T cg13628971 chr7:2884303 GNA12 0.42 5.5 0.32 9.03e-8 Height; CESC cis rs7592578 0.825 rs12477369 chr2:191455624 G/T cg10560079 chr2:191398806 TMEM194B 0.59 5.19 0.3 4.11e-7 Diastolic blood pressure; CESC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Parkinson's disease; CESC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg04369109 chr6:150039330 LATS1 -0.44 -6.21 -0.36 2.05e-9 Lung cancer; CESC cis rs7584330 0.554 rs10208231 chr2:238433225 C/T cg14458575 chr2:238380390 NA 0.49 5.42 0.32 1.35e-7 Prostate cancer; CESC cis rs17655565 0.543 rs2298797 chr12:52755189 A/G cg00777198 chr12:52828273 KRT75 0.36 5.04 0.3 8.69e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs35110281 0.712 rs1454648 chr21:45053815 C/T cg04455712 chr21:45112962 RRP1B 0.38 5.58 0.32 5.8e-8 Mean corpuscular volume; CESC trans rs11252926 0.501 rs2050971 chr10:525530 T/G cg00953403 chr17:74099816 EXOC7 -0.49 -6.18 -0.35 2.4e-9 Psychosis in Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20235337 chr6:42981612 MEA1;KLHDC3 0.58 6.21 0.36 2.06e-9 Gut microbiome composition (summer); CESC cis rs4481887 0.679 rs4466692 chr1:248423174 C/G cg00666640 chr1:248458726 OR2T12 0.35 5.94 0.34 9.16e-9 Common traits (Other); CESC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg19163074 chr7:65112434 INTS4L2 0.42 5.28 0.31 2.73e-7 Aortic root size; CESC cis rs1153858 1.000 rs66528868 chr15:45668547 A/C cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs17253792 0.822 rs13379343 chr14:56050205 G/A cg01858014 chr14:56050164 KTN1 -0.95 -7.37 -0.41 2.23e-12 Putamen volume; CESC cis rs9399135 0.967 rs3756799 chr6:135341011 A/G cg24558204 chr6:135376177 HBS1L 0.49 6.8 0.39 6.8e-11 Red blood cell count; CESC cis rs763121 0.853 rs1013338 chr22:38974154 C/A cg06022373 chr22:39101656 GTPBP1 0.93 16.47 0.71 1.81e-42 Menopause (age at onset); CESC cis rs10791097 0.694 rs7106973 chr11:130758113 G/A cg09137382 chr11:130731461 NA 0.36 5.27 0.31 2.78e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs7159888 0.727 rs11847263 chr14:65775695 A/C cg21287597 chr13:114000024 GRTP1 0.45 6.01 0.35 6.23e-9 IgG glycosylation;N-glycan levels; CESC cis rs71277158 0.688 rs73879167 chr3:169776194 T/G cg04067573 chr3:169899625 PHC3 0.55 5.7 0.33 3.25e-8 Prostate cancer; CESC cis rs17641971 0.645 rs341805 chr8:50034658 T/G cg00325661 chr8:49890786 NA 0.39 5.28 0.31 2.64e-7 Blood metabolite levels; CESC cis rs9929218 0.954 rs17715799 chr16:68830511 A/T cg02972257 chr16:68554789 NA 0.46 5.42 0.32 1.33e-7 Colorectal cancer; CESC cis rs896854 0.738 rs481887 chr8:95967838 A/G cg23172400 chr8:95962367 TP53INP1 0.4 7.41 0.41 1.68e-12 Type 2 diabetes; CESC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg04944784 chr2:26401820 FAM59B -0.8 -8.93 -0.48 7.17e-17 Gut microbiome composition (summer); CESC cis rs7851660 0.809 rs12550872 chr9:100653128 G/A cg13688889 chr9:100608707 NA -0.63 -8.96 -0.48 5.96e-17 Strep throat; CESC cis rs8092503 0.859 rs35509548 chr18:52472408 A/G cg12377874 chr18:52495404 RAB27B 0.37 5.94 0.34 8.77e-9 Childhood body mass index; CESC cis rs9308731 0.591 rs55878194 chr2:111940474 C/G cg04202892 chr2:111875749 ACOXL 0.37 5.18 0.3 4.49e-7 Chronic lymphocytic leukemia; CESC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.48 0.32 9.89e-8 Bipolar disorder; CESC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg18337363 chr3:52569053 NT5DC2 0.29 5.08 0.3 7.02e-7 Bipolar disorder; CESC cis rs2046867 0.819 rs34132129 chr3:72829100 A/G cg25664220 chr3:72788482 NA -0.46 -6.67 -0.38 1.51e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC trans rs11098499 0.505 rs75122014 chr4:120362426 G/C cg25214090 chr10:38739885 LOC399744 0.7 9.9 0.52 7.24e-20 Corneal astigmatism; CESC cis rs35146811 0.961 rs1880949 chr7:99722266 A/C cg22906224 chr7:99728672 NA -0.47 -5.55 -0.32 7.05e-8 Coronary artery disease; CESC trans rs11148252 0.532 rs9536262 chr13:53303074 A/C cg18335740 chr13:41363409 SLC25A15 -0.55 -7.5 -0.42 9.4e-13 Lewy body disease; CESC cis rs3796352 1.000 rs71301814 chr3:53117663 G/A cg07884673 chr3:53033167 SFMBT1 0.66 5.57 0.32 6.19e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs113835537 0.935 rs11550057 chr11:66392880 C/T cg22134325 chr11:66188745 NPAS4 0.5 5.76 0.33 2.27e-8 Airway imaging phenotypes; CESC cis rs8016982 0.674 rs61980899 chr14:81676844 T/C cg01989461 chr14:81687754 GTF2A1 0.75 11.76 0.59 5.62e-26 Schizophrenia; CESC cis rs9814567 0.964 rs3856729 chr3:134200925 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.37 -0.36 8.13e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs672059 0.967 rs514183 chr1:183163174 A/C ch.1.3577855R chr1:183094577 LAMC1 0.58 7.5 0.42 9.59e-13 Hypertriglyceridemia; CESC cis rs17433780 0.504 rs1409150 chr1:89473175 A/G cg09516651 chr1:89888402 LOC400759 0.48 6.8 0.39 6.92e-11 Carotid intima media thickness; CESC cis rs4523957 0.928 rs4790072 chr17:2173497 A/G cg16513277 chr17:2031491 SMG6 -0.59 -7.99 -0.44 4.21e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.14 -0.3 5.22e-7 Lung cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10484450 chr14:67982152 TMEM229B -0.53 -7.0 -0.4 2.1e-11 Asthma; CESC cis rs59918340 0.728 rs6987335 chr8:142235358 T/G cg23750338 chr8:142222470 SLC45A4 -0.59 -9.01 -0.48 4.12e-17 Immature fraction of reticulocytes; CESC cis rs1707322 1.000 rs1768807 chr1:46510570 A/G cg05343316 chr1:45956843 TESK2 -0.44 -5.44 -0.32 1.2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6570726 0.935 rs386344 chr6:145855622 A/G cg23711669 chr6:146136114 FBXO30 0.8 11.39 0.57 1e-24 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26684574 chr20:48532295 SPATA2 -0.53 -7.28 -0.41 3.79e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7312933 0.558 rs11181422 chr12:42718552 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.4 -0.37 7.09e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs459571 0.883 rs2520096 chr9:136919416 A/G cg13789015 chr9:136890014 NCRNA00094 0.54 7.91 0.44 6.88e-14 Platelet distribution width; CESC cis rs9303280 0.901 rs2290400 chr17:38066240 A/G cg20243544 chr17:37824526 PNMT 0.41 5.26 0.31 2.98e-7 Self-reported allergy; CESC cis rs2486288 0.656 rs6493143 chr15:45570781 G/T cg21132104 chr15:45694354 SPATA5L1 -0.57 -6.66 -0.38 1.55e-10 Glomerular filtration rate; CESC cis rs4722166 0.508 rs1474348 chr7:22767908 C/G cg26061582 chr7:22766209 IL6 0.47 5.32 0.31 2.26e-7 Lung cancer; CESC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg10792982 chr14:105748885 BRF1 0.42 5.38 0.31 1.63e-7 Mean platelet volume;Platelet distribution width; CESC cis rs4909189 1.000 rs12698214 chr7:158136204 T/G cg25566285 chr7:158114605 PTPRN2 0.44 5.48 0.32 9.93e-8 Response to amphetamines; CESC cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg05283184 chr6:79620031 NA -0.42 -6.49 -0.37 4.09e-10 Intelligence (multi-trait analysis); CESC cis rs916888 0.821 rs199509 chr17:44858728 G/A cg17911788 chr17:44343683 NA 0.53 7.2 0.4 6.14e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg19346786 chr7:2764209 NA -0.45 -6.53 -0.37 3.3e-10 Height; CESC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg17372223 chr3:52568218 NT5DC2 0.44 6.57 0.37 2.6e-10 Bipolar disorder; CESC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg10691866 chr7:65817282 TPST1 0.35 5.9 0.34 1.12e-8 Aortic root size; CESC cis rs6582630 0.519 rs4406888 chr12:38293312 A/C cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.23e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.34 5.54 0.32 7.38e-8 Monocyte percentage of white cells; CESC cis rs7267979 1.000 rs2258884 chr20:25279539 C/T cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2228479 0.717 rs11649210 chr16:89807233 C/G cg04013166 chr16:89971882 TCF25 0.72 7.86 0.43 9.59e-14 Skin colour saturation; CESC cis rs8072100 0.967 rs4338849 chr17:45512483 A/G cg25173405 chr17:45401733 C17orf57 -0.4 -5.42 -0.32 1.34e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9549260 0.816 rs7324090 chr13:41253958 A/T cg21288729 chr13:41239152 FOXO1 0.63 8.2 0.45 1.02e-14 Red blood cell count; CESC cis rs2404602 0.692 rs36070630 chr15:76949259 T/C cg26408565 chr15:76604113 ETFA -0.4 -5.68 -0.33 3.58e-8 Blood metabolite levels; CESC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg11644478 chr21:40555479 PSMG1 -0.86 -12.94 -0.62 5.36e-30 Cognitive function; CESC cis rs6061231 0.793 rs2427320 chr20:60976723 A/G cg24112000 chr20:60950667 NA -0.57 -7.01 -0.4 1.96e-11 Colorectal cancer; CESC cis rs6499129 0.867 rs4360931 chr16:67471926 C/G cg26727032 chr16:67993705 SLC12A4 -0.58 -5.99 -0.35 6.84e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg25319279 chr11:5960081 NA 0.33 5.06 0.3 8.03e-7 DNA methylation (variation); CESC cis rs1729951 0.575 rs10935214 chr3:136693485 G/A cg25687071 chr3:136751404 NA 0.39 5.19 0.3 4.27e-7 Neuroticism; CESC cis rs11030122 0.569 rs11030781 chr11:4083258 T/C cg18678763 chr11:4115507 RRM1 -0.42 -5.66 -0.33 3.85e-8 Mean platelet volume;Platelet distribution width; CESC cis rs10504229 0.679 rs72649131 chr8:58054288 G/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.28 -0.41 3.76e-12 Developmental language disorder (linguistic errors); CESC cis rs2228479 0.850 rs11076623 chr16:89844120 G/T cg04013166 chr16:89971882 TCF25 0.78 6.65 0.38 1.64e-10 Skin colour saturation; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg09015484 chr9:96929106 NA -0.44 -6.15 -0.35 2.81e-9 Height; CESC cis rs2228479 0.850 rs62056103 chr16:89942781 G/A cg14709524 chr16:89940631 TCF25 0.88 6.44 0.37 5.5e-10 Skin colour saturation; CESC cis rs6912958 1.000 rs9294379 chr6:88152535 C/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -7.57 -0.42 6.2e-13 Monocyte percentage of white cells; CESC cis rs7223966 0.961 rs35844156 chr17:61837568 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.31 0.36 1.16e-9 Hip circumference adjusted for BMI;Body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08083689 chr4:8442326 ACOX3 -0.44 -6.04 -0.35 5.25e-9 Gambling; CESC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg02951883 chr7:2050386 MAD1L1 0.5 6.8 0.39 6.73e-11 Bipolar disorder and schizophrenia; CESC cis rs2842992 0.714 rs2475564 chr6:160123673 A/G cg11366901 chr6:160182831 ACAT2 0.83 10.24 0.53 6.02e-21 Age-related macular degeneration (geographic atrophy); CESC cis rs1062177 1.000 rs17804178 chr5:151197729 T/G cg00977110 chr5:151150581 G3BP1 0.63 6.65 0.38 1.66e-10 Preschool internalizing problems; CESC cis rs5758659 0.622 rs6519298 chr22:42364997 C/T cg15557168 chr22:42548783 NA -0.42 -6.28 -0.36 1.4e-9 Cognitive function; CESC cis rs742614 0.533 rs2092737 chr20:32428135 A/C cg06304546 chr20:32448765 NA -0.41 -5.29 -0.31 2.57e-7 Stearic acid (18:0) levels; CESC cis rs35123781 0.696 rs4912756 chr5:139070780 A/T cg10513866 chr5:139070639 NA 0.43 6.01 0.35 6.06e-9 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03803784 chr12:51157550 ATF1 0.57 6.14 0.35 3.05e-9 Gut microbiome composition (summer); CESC cis rs7872515 0.536 rs7852989 chr9:94782453 G/C cg01248375 chr9:94877805 SPTLC1 0.59 5.08 0.3 7.23e-7 Bipolar disorder and schizophrenia; CESC cis rs6783573 0.711 rs3806701 chr3:46617337 G/A cg21489266 chr3:46619131 LRRC2;TDGF1 -0.54 -7.79 -0.43 1.48e-13 Cerebrospinal fluid biomarker levels; CESC cis rs9640161 0.789 rs11767409 chr7:150058043 C/T cg21361702 chr7:150065534 REPIN1 0.61 6.72 0.38 1.13e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs6088580 0.634 rs4911423 chr20:32999386 T/A cg24642439 chr20:33292090 TP53INP2 -0.53 -6.98 -0.39 2.39e-11 Glomerular filtration rate (creatinine); CESC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg24733560 chr20:60626293 TAF4 -0.42 -5.74 -0.33 2.53e-8 Body mass index; CESC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg10351095 chr21:47802916 PCNT -0.45 -6.19 -0.36 2.33e-9 Testicular germ cell tumor; CESC cis rs11711311 1.000 rs12632983 chr3:113481913 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.59 7.77 0.43 1.71e-13 IgG glycosylation; CESC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg19318889 chr4:1322082 MAEA -0.46 -5.94 -0.34 9.14e-9 Obesity-related traits; CESC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg12564285 chr5:131593104 PDLIM4 0.39 5.88 0.34 1.23e-8 Breast cancer; CESC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg18230493 chr5:56204884 C5orf35 -0.81 -9.69 -0.51 3.23e-19 Initial pursuit acceleration; CESC cis rs12477438 0.798 rs9808541 chr2:99642179 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs3118233 1 rs3118233 chr16:68733646 G/C cg02972257 chr16:68554789 NA 0.48 5.69 0.33 3.36e-8 Red cell distribution width; CESC cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg21395723 chr22:39101663 GTPBP1 0.42 5.3 0.31 2.39e-7 Menopause (age at onset); CESC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.21e-8 Lung cancer; CESC cis rs9291683 0.655 rs55941493 chr4:10100341 G/A cg00071950 chr4:10020882 SLC2A9 -0.56 -8.65 -0.47 5.19e-16 Bone mineral density; CESC cis rs9815354 1.000 rs12639255 chr3:41861738 T/C cg03022575 chr3:42003672 ULK4 0.48 5.38 0.31 1.68e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg10541313 chr22:46663664 TTC38 0.61 5.14 0.3 5.24e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9611565 0.592 rs28750375 chr22:41990644 A/C cg17376030 chr22:41985996 PMM1 0.49 5.49 0.32 9.5e-8 Vitiligo; CESC cis rs3820068 0.655 rs11587521 chr1:15839206 T/C cg18192808 chr1:15853278 DNAJC16 0.46 5.53 0.32 7.56e-8 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.2.2017299F chr2:97269742 KIAA1310 -0.55 -6.37 -0.36 8.49e-10 Gut microbiome composition (summer); CESC cis rs362272 0.524 rs2749781 chr4:3346617 T/C cg14583973 chr4:3374767 RGS12 0.33 5.6 0.33 5.34e-8 Serum sulfate level; CESC cis rs4072980 0.524 rs28442147 chr1:38395410 T/A cg12658694 chr1:38397304 INPP5B 0.7 9.78 0.51 1.79e-19 Coronary artery disease; CESC cis rs1062177 0.855 rs62395861 chr5:151269270 A/G cg00977110 chr5:151150581 G3BP1 0.62 6.49 0.37 4.31e-10 Preschool internalizing problems; CESC cis rs854765 0.583 rs11078405 chr17:17824978 G/T cg04398451 chr17:18023971 MYO15A -0.65 -9.23 -0.49 9.1e-18 Total body bone mineral density; CESC cis rs7267979 0.868 rs6107019 chr20:25233985 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.1 0.68 1.39e-37 Liver enzyme levels (alkaline phosphatase); CESC cis rs60311166 1.000 rs934839 chr3:52683898 G/T cg13174197 chr3:52720522 GNL3;PBRM1 0.62 5.15 0.3 5.03e-7 CTACK levels; CESC trans rs61931739 0.534 rs4365131 chr12:34053308 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.23 0.41 5.25e-12 Morning vs. evening chronotype; CESC cis rs67311347 0.869 rs7646899 chr3:40366982 A/G cg24209194 chr3:40518798 ZNF619 0.4 5.03 0.3 9.09e-7 Renal cell carcinoma; CESC cis rs9291683 0.620 rs4444830 chr4:10124819 A/G cg00071950 chr4:10020882 SLC2A9 -0.53 -7.28 -0.41 3.86e-12 Bone mineral density; CESC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg09877947 chr5:131593287 PDLIM4 0.48 6.27 0.36 1.43e-9 Breast cancer; CESC cis rs10751667 0.643 rs7395613 chr11:933873 C/T cg20946044 chr11:1010712 AP2A2 -0.4 -5.43 -0.32 1.26e-7 Alzheimer's disease (late onset); CESC cis rs9894429 0.789 rs7502346 chr17:79603741 T/C cg18240062 chr17:79603768 NPLOC4 0.9 13.24 0.63 4.59e-31 Eye color traits; CESC cis rs11690935 0.632 rs62183783 chr2:172865775 A/G cg13550731 chr2:172543902 DYNC1I2 0.46 6.26 0.36 1.53e-9 Schizophrenia; CESC cis rs6570726 0.935 rs424263 chr6:145840073 A/C cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.36e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs597539 0.690 rs7129960 chr11:68622456 A/G cg18350739 chr11:68623251 NA -0.46 -6.64 -0.38 1.8e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25549747 chr13:21750870 MRP63;SKA3 -0.46 -6.36 -0.36 8.79e-10 Fibrinogen levels; CESC cis rs9486719 0.843 rs2205754 chr6:96843134 T/C cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs12042938 0.935 rs823159 chr1:231777168 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.47 6.57 0.37 2.65e-10 Neuranatomic and neurocognitive phenotypes; CESC cis rs9913156 0.793 rs4346260 chr17:4567215 A/G cg19197139 chr17:4613644 ARRB2 -0.92 -10.59 -0.55 4.42e-22 Lymphocyte counts; CESC cis rs2299587 0.689 rs2285303 chr8:17797409 A/G cg08627089 chr8:17753878 FGL1 -0.42 -5.65 -0.33 4.24e-8 Economic and political preferences; CESC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.11e-8 Alzheimer's disease; CESC cis rs11638352 1.000 rs2706473 chr15:44417735 C/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs2249694 0.919 rs10857769 chr10:135405047 T/C cg20169779 chr10:135381914 SYCE1 -0.4 -5.67 -0.33 3.78e-8 Obesity-related traits; CESC cis rs7851660 0.844 rs13287360 chr9:100637681 A/G cg13688889 chr9:100608707 NA -0.64 -8.94 -0.48 6.74e-17 Strep throat; CESC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.47 -0.32 1.04e-7 Lung cancer; CESC cis rs11711311 1.000 rs9865435 chr3:113450046 G/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.27 0.53 4.81e-21 IgG glycosylation; CESC cis rs10789491 0.565 rs2897107 chr1:47206178 A/T cg15501359 chr1:47185051 KIAA0494 0.76 7.4 0.41 1.82e-12 Response to hepatitis C treatment; CESC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg27266027 chr21:40555129 PSMG1 0.44 5.18 0.3 4.43e-7 Cognitive function; CESC cis rs7116495 1.000 rs7128317 chr11:71701367 C/T cg26138937 chr11:71823887 C11orf51 0.79 6.9 0.39 3.88e-11 Severe influenza A (H1N1) infection; CESC cis rs6963495 0.818 rs116845562 chr7:105217038 T/C cg02135003 chr7:105160482 PUS7 -0.47 -5.47 -0.32 1.04e-7 Bipolar disorder (body mass index interaction); CESC cis rs1215050 0.791 rs2123100 chr4:98803747 T/C cg05340658 chr4:99064831 C4orf37 0.52 6.88 0.39 4.36e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2276314 0.857 rs4799408 chr18:33588982 C/T cg05985134 chr18:33552581 C18orf21 -0.63 -7.6 -0.42 5.2e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg19163074 chr7:65112434 INTS4L2 0.43 5.34 0.31 2e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08755283 chr5:118324104 DTWD2 -0.45 -6.51 -0.37 3.74e-10 Fibrinogen levels; CESC cis rs4535700 0.501 rs6943341 chr7:55975182 A/T cg09872392 chr7:56161020 PHKG1 0.4 5.77 0.33 2.19e-8 Macular telangiectasia type 2; CESC cis rs858239 0.730 rs858279 chr7:23251005 T/C cg23682824 chr7:23144976 KLHL7 0.42 5.72 0.33 2.86e-8 Cerebrospinal fluid biomarker levels; CESC cis rs2243480 1.000 rs313831 chr7:65551226 C/T cg18252515 chr7:66147081 NA -1.37 -13.58 -0.64 2.97e-32 Diabetic kidney disease; CESC cis rs1878931 0.582 rs4785933 chr16:3419741 T/A cg02880119 chr16:3481970 NA -0.42 -5.42 -0.32 1.32e-7 Body mass index (adult); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24306142 chr1:17231793 NA -0.61 -6.75 -0.38 9.23e-11 Gut microbiome composition (summer); CESC cis rs3806843 0.750 rs2563285 chr5:140126137 T/C cg26395211 chr5:140044315 WDR55 0.41 5.25 0.31 3.1e-7 Depressive symptoms (multi-trait analysis); CESC cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg00255919 chr5:131827918 IRF1 0.35 5.23 0.31 3.45e-7 Breast cancer;Mosquito bite size; CESC cis rs950776 0.518 rs12916483 chr15:78832397 G/A cg06917634 chr15:78832804 PSMA4 0.81 12.32 0.6 6.91e-28 Sudden cardiac arrest; CESC trans rs7902708 0.920 rs12256387 chr10:54422872 C/A cg26219051 chr22:43739629 SCUBE1 -0.48 -6.19 -0.36 2.25e-9 Bone properties (heel); CESC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg05025164 chr4:1340916 KIAA1530 -0.88 -12.05 -0.59 5.84e-27 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07352001 chr10:44144445 ZNF32 0.56 6.15 0.35 2.86e-9 Gut microbiome composition (summer); CESC cis rs3820928 1.000 rs59904960 chr2:227761269 T/C cg05526886 chr2:227700861 RHBDD1 -0.42 -5.38 -0.31 1.64e-7 Pulmonary function; CESC cis rs2404602 0.716 rs1874944 chr15:76863928 A/G cg26408565 chr15:76604113 ETFA -0.4 -5.72 -0.33 2.92e-8 Blood metabolite levels; CESC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg07936489 chr17:37558343 FBXL20 0.77 10.62 0.55 3.6e-22 Glomerular filtration rate (creatinine); CESC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg15445000 chr17:37608096 MED1 0.42 6.91 0.39 3.71e-11 Glomerular filtration rate (creatinine); CESC trans rs11098499 1.000 rs28419773 chr4:120211061 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.37 0.5 3.4e-18 Corneal astigmatism; CESC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg17724175 chr1:150552817 MCL1 0.33 5.15 0.3 5.14e-7 Melanoma; CESC cis rs8067354 0.540 rs7221472 chr17:58036737 C/T cg02344993 chr17:57696989 CLTC 0.53 5.41 0.32 1.4e-7 Hemoglobin concentration; CESC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg11644478 chr21:40555479 PSMG1 -0.56 -7.58 -0.42 5.83e-13 Menarche (age at onset); CESC cis rs7833790 0.676 rs7834555 chr8:82697625 A/G cg02079420 chr8:82753780 SNX16 0.5 7.56 0.42 6.82e-13 Diastolic blood pressure; CESC cis rs4629180 0.586 rs1848699 chr2:102137903 C/G cg04415270 chr2:102091202 RFX8 -0.3 -5.24 -0.31 3.24e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs74054849 0.541 rs12094673 chr1:15914820 T/C cg17385448 chr1:15911702 AGMAT 0.53 5.21 0.3 3.83e-7 Alcoholic chronic pancreatitis; CESC cis rs7173419 0.607 rs1800411 chr15:28211921 A/G cg20906524 chr15:28200668 OCA2 0.37 5.03 0.3 9.22e-7 Eye color; CESC cis rs6121246 0.559 rs6058352 chr20:30269179 T/C cg13852791 chr20:30311386 BCL2L1 0.81 10.51 0.54 8.04e-22 Mean corpuscular hemoglobin; CESC cis rs7666738 0.606 rs7663216 chr4:99088385 A/C cg17366294 chr4:99064904 C4orf37 0.42 5.67 0.33 3.76e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6542838 0.582 rs6542845 chr2:99537600 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -5.66 -0.33 3.95e-8 Fear of minor pain; CESC cis rs78132593 0.757 rs41305070 chr1:150666860 A/G cg04414720 chr1:150670196 GOLPH3L -0.54 -5.43 -0.32 1.27e-7 High light scatter reticulocyte count; CESC cis rs2952156 0.959 rs1495101 chr17:37832103 C/A cg00129232 chr17:37814104 STARD3 -0.71 -9.32 -0.5 4.68e-18 Asthma; CESC cis rs7202877 0.610 rs3851735 chr16:75372092 A/G cg04384234 chr16:75411784 CFDP1 -0.5 -5.85 -0.34 1.42e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg05872129 chr22:39784769 NA 0.83 11.54 0.58 3.12e-25 Intelligence (multi-trait analysis); CESC cis rs2204008 0.580 rs11174421 chr12:38105138 A/G cg26384229 chr12:38710491 ALG10B 0.7 9.44 0.5 2.07e-18 Bladder cancer; CESC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg27535305 chr1:53392650 SCP2 -0.32 -5.31 -0.31 2.34e-7 Monocyte count; CESC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg24675658 chr1:53192096 ZYG11B -0.62 -7.63 -0.42 4.16e-13 Monocyte count; CESC cis rs7628338 0.525 rs13072744 chr3:72509637 C/T cg22685502 chr3:72496851 RYBP -0.27 -6.21 -0.36 2.08e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC trans rs11148252 0.553 rs9536219 chr13:53227301 C/T cg18335740 chr13:41363409 SLC25A15 0.52 7.02 0.4 1.89e-11 Lewy body disease; CESC cis rs10791097 0.694 rs2155751 chr11:130755240 G/A cg12179176 chr11:130786555 SNX19 0.65 10.15 0.53 1.18e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg07414643 chr4:187882934 NA 0.52 7.65 0.43 3.84e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.9e-10 Life satisfaction; CESC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg08859206 chr1:53392774 SCP2 -0.6 -8.04 -0.44 3.07e-14 Monocyte count; CESC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg22974920 chr21:40686053 BRWD1 -0.47 -5.72 -0.33 2.89e-8 Cognitive function; CESC cis rs3862030 0.810 rs11593710 chr10:104328719 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.4 -5.4 -0.31 1.47e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs3749237 0.595 rs11720264 chr3:49580347 C/T cg07636037 chr3:49044803 WDR6 0.6 8.78 0.47 2.1e-16 Resting heart rate; CESC cis rs4253772 0.591 rs11703245 chr22:46684890 A/G cg03036452 chr22:46663545 TTC38 0.64 5.03 0.3 9.16e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7149337 0.836 rs35345236 chr14:51671817 T/C cg23942311 chr14:51606299 NA 0.44 7.47 0.42 1.17e-12 Cancer; CESC cis rs12545109 0.800 rs1440747 chr8:57417924 G/T cg09654669 chr8:57350985 NA 0.53 6.09 0.35 3.89e-9 Obesity-related traits; CESC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg05861140 chr6:150128134 PCMT1 0.36 5.17 0.3 4.59e-7 Lung cancer; CESC cis rs6032067 0.777 rs13038342 chr20:43800232 C/T cg10761708 chr20:43804764 PI3 0.55 6.64 0.38 1.82e-10 Blood protein levels; CESC cis rs75229567 0.618 rs11177819 chr12:70134836 T/G cg10114359 chr12:70132523 RAB3IP 1.2 7.96 0.44 5.07e-14 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs4820294 0.961 rs62236664 chr22:38059427 T/C cg21798802 chr22:38057573 PDXP 0.46 7.93 0.44 6.33e-14 Fat distribution (HIV); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27098574 chr16:75285489 BCAR1 0.53 6.23 0.36 1.84e-9 Gut microbiome composition (summer); CESC cis rs28595532 0.800 rs114321375 chr4:119341663 G/A cg21605333 chr4:119757512 SEC24D 1.01 5.69 0.33 3.4e-8 Cannabis dependence symptom count; CESC trans rs7246760 1.000 rs73014068 chr19:9922783 T/C cg02900749 chr2:68251473 NA -0.83 -7.08 -0.4 1.3e-11 Pursuit maintenance gain; CESC cis rs72945132 0.882 rs67283107 chr11:70221204 C/T cg00319359 chr11:70116639 PPFIA1 0.71 6.71 0.38 1.18e-10 Coronary artery disease; CESC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg11494091 chr17:61959527 GH2 0.72 12.07 0.6 4.93e-27 Prudent dietary pattern; CESC cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg19077165 chr18:44547161 KATNAL2 -0.64 -9.69 -0.51 3.35e-19 Personality dimensions; CESC cis rs763121 0.853 rs5757204 chr22:39046700 A/C cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC cis rs6546550 0.935 rs13392884 chr2:70036711 A/G cg02498382 chr2:70120550 SNRNP27 -0.38 -6.47 -0.37 4.83e-10 Prevalent atrial fibrillation; CESC trans rs6828577 0.819 rs368669 chr4:119634275 A/G cg05098011 chr1:151736092 OAZ3;MRPL9 0.48 6.02 0.35 5.93e-9 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs2235642 0.893 rs2143285 chr16:1593171 A/G cg08296037 chr16:1584118 IFT140;TMEM204 -0.32 -5.27 -0.31 2.77e-7 Coronary artery disease; CESC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg11494091 chr17:61959527 GH2 0.74 12.88 0.62 8.12e-30 Prudent dietary pattern; CESC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg06456125 chr7:65229604 NA -0.4 -5.15 -0.3 5.11e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10063512 chr8:37594142 ERLIN2 0.63 7.25 0.41 4.57e-12 Gut microbiome composition (summer); CESC cis rs62432291 0.681 rs445957 chr6:159662064 C/T cg14500486 chr6:159655392 FNDC1 -0.63 -6.56 -0.37 2.84e-10 Joint mobility (Beighton score); CESC trans rs7615952 0.932 rs1976458 chr3:125647512 T/G cg07211511 chr3:129823064 LOC729375 -1.14 -15.22 -0.68 5.24e-38 Blood pressure (smoking interaction); CESC cis rs763014 0.898 rs4984897 chr16:632180 G/C cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg21644426 chr2:191273491 MFSD6 0.48 6.59 0.38 2.33e-10 Pulse pressure; CESC cis rs7524258 0.903 rs6577424 chr1:7292417 C/T cg07173049 chr1:7289937 CAMTA1 -0.44 -6.61 -0.38 2.1e-10 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs3820928 0.839 rs13404750 chr2:227876129 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -5.52 -0.32 8.19e-8 Pulmonary function; CESC cis rs7243790 0.774 rs62091573 chr18:51939055 G/A cg04730925 chr18:51795821 POLI -0.43 -5.75 -0.33 2.4e-8 Diastolic blood pressure; CESC cis rs11792861 0.816 rs2275637 chr9:111696043 C/G cg13535736 chr9:111863775 C9orf5 -0.47 -6.19 -0.36 2.22e-9 Menarche (age at onset); CESC cis rs62064224 0.765 rs62065463 chr17:30732405 G/T cg25809561 chr17:30822961 MYO1D 0.59 8.47 0.46 1.77e-15 Schizophrenia; CESC cis rs6831352 0.879 rs2602879 chr4:100040652 G/A cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Alcohol dependence; CESC cis rs6032067 0.777 rs35434469 chr20:43778544 C/T cg11264863 chr20:43835661 SEMG1 0.49 5.1 0.3 6.5e-7 Blood protein levels; CESC cis rs826838 0.654 rs7977738 chr12:38722460 G/A cg26384229 chr12:38710491 ALG10B 0.57 8.22 0.45 9.19e-15 Heart rate; CESC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg24562669 chr7:97807699 LMTK2 0.47 6.6 0.38 2.21e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs910316 0.935 rs2268620 chr14:75640403 G/A cg11812906 chr14:75593930 NEK9 -0.88 -14.42 -0.66 3.46e-35 Height; CESC cis rs523522 0.923 rs3916065 chr12:120934624 A/C cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs1568889 0.938 rs11601602 chr11:28233768 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.71 8.25 0.45 7.7e-15 Bipolar disorder; CESC cis rs7666738 0.830 rs6839203 chr4:98839814 C/G cg05340658 chr4:99064831 C4orf37 0.72 10.19 0.53 8.89e-21 Colonoscopy-negative controls vs population controls; CESC cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg03388025 chr16:89894329 SPIRE2 -0.32 -5.7 -0.33 3.19e-8 Vitiligo; CESC cis rs34779708 0.931 rs4934524 chr10:35270921 G/C cg04310649 chr10:35416472 CREM -0.5 -5.97 -0.34 7.5e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs1728785 0.892 rs1617749 chr16:68580890 A/G cg02972257 chr16:68554789 NA -0.62 -6.88 -0.39 4.41e-11 Ulcerative colitis; CESC cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg10556349 chr10:835070 NA 0.72 6.11 0.35 3.52e-9 Eosinophil percentage of granulocytes; CESC cis rs28655083 0.828 rs9938028 chr16:77127830 A/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.41 5.24 0.31 3.23e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs2425143 1.000 rs28685274 chr20:34358527 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -8.0 -0.44 3.85e-14 Blood protein levels; CESC cis rs4689592 0.587 rs3822269 chr4:7069901 T/C cg26116260 chr4:7069785 GRPEL1 0.95 12.78 0.62 1.81e-29 Monocyte percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00969680 chr1:113466087 AFARP1;SLC16A1 0.57 7.71 0.43 2.57e-13 Fibrinogen levels; CESC trans rs4335177 0.642 rs10816403 chr9:109371518 T/C cg12580783 chr12:49362475 WNT10B -0.32 -6.27 -0.36 1.45e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27171280 chr4:89205853 PPM1K 0.6 7.0 0.4 2.14e-11 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg13206674 chr6:150067644 NUP43 0.46 6.59 0.38 2.43e-10 Lung cancer; CESC cis rs208520 1.000 rs72884033 chr6:66995747 T/C cg07460842 chr6:66804631 NA 0.88 9.99 0.52 3.87e-20 Exhaled nitric oxide output; CESC cis rs854765 0.647 rs7406744 chr17:17981938 C/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 5.88 0.34 1.24e-8 Total body bone mineral density; CESC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs9911578 1.000 rs12940681 chr17:56933622 T/C cg12560992 chr17:57184187 TRIM37 0.92 15.53 0.69 3.91e-39 Intelligence (multi-trait analysis); CESC cis rs854765 0.547 rs4925135 chr17:17952868 T/C cg09796270 chr17:17721594 SREBF1 -0.38 -5.07 -0.3 7.66e-7 Total body bone mineral density; CESC cis rs6963495 0.818 rs6961863 chr7:105180953 C/T cg19920283 chr7:105172520 RINT1 0.77 8.17 0.45 1.24e-14 Bipolar disorder (body mass index interaction); CESC cis rs9359856 0.564 rs72917989 chr6:90470385 A/T cg13799429 chr6:90582589 CASP8AP2 -0.61 -5.64 -0.33 4.36e-8 Bipolar disorder; CESC cis rs807669 1.000 rs807670 chr22:19154608 A/C cg02655711 chr22:19163373 SLC25A1 0.66 10.17 0.53 9.83e-21 Metabolite levels; CESC cis rs4319547 0.695 rs55834409 chr12:122862560 C/G cg05707623 chr12:122985044 ZCCHC8 0.53 5.92 0.34 1.01e-8 Body mass index; CESC cis rs2228479 0.702 rs17177891 chr16:89799950 C/T cg14709524 chr16:89940631 TCF25 0.81 5.97 0.34 7.63e-9 Skin colour saturation; CESC cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg05340658 chr4:99064831 C4orf37 0.77 11.71 0.58 8.52e-26 Colonoscopy-negative controls vs population controls; CESC cis rs16957304 1.000 rs8062484 chr16:67343932 G/T cg26727032 chr16:67993705 SLC12A4 -0.52 -5.13 -0.3 5.74e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs897984 0.762 rs12931046 chr16:30987144 G/A cg00531865 chr16:30841666 NA 0.5 6.8 0.39 6.84e-11 Dementia with Lewy bodies; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11281249 chr2:198570061 MARS2 0.57 6.56 0.37 2.83e-10 Gut microbiome composition (summer); CESC cis rs36051895 0.623 rs28872016 chr9:5253558 T/G cg02405213 chr9:5042618 JAK2 -0.54 -6.37 -0.36 8.34e-10 Pediatric autoimmune diseases; CESC cis rs6547741 0.935 rs2384626 chr2:27773648 A/G cg27432699 chr2:27873401 GPN1 0.44 6.05 0.35 4.98e-9 Oral cavity cancer; CESC cis rs9905704 0.681 rs2531730 chr17:56545069 T/G cg12560992 chr17:57184187 TRIM37 -0.59 -5.62 -0.33 4.89e-8 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02136628 chr17:41476456 ARL4D 0.59 6.7 0.38 1.21e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg00149659 chr3:10157352 C3orf10 0.69 8.12 0.45 1.77e-14 Alzheimer's disease; CESC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg21724239 chr8:58056113 NA 0.57 5.76 0.33 2.29e-8 Developmental language disorder (linguistic errors); CESC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 11.97 0.59 1.14e-26 Alzheimer's disease; CESC cis rs9303542 0.559 rs1042822 chr17:46620095 G/T cg04904318 chr17:46607828 HOXB1 -0.57 -5.49 -0.32 9.47e-8 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs9815354 1.000 rs9869207 chr3:41878661 C/G cg03022575 chr3:42003672 ULK4 0.45 5.29 0.31 2.59e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg02297831 chr4:17616191 MED28 0.5 6.01 0.35 6.14e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs734999 0.549 rs6667564 chr1:2520302 T/C cg18854424 chr1:2615690 NA 0.29 5.58 0.32 5.84e-8 Ulcerative colitis; CESC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg24881330 chr22:46731750 TRMU 0.86 7.93 0.44 6.15e-14 LDL cholesterol;Cholesterol, total; CESC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.21e-8 Lung cancer; CESC cis rs16866061 0.515 rs1027340 chr2:225370554 C/A cg12698349 chr2:225449008 CUL3 0.84 14.81 0.67 1.42e-36 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs6500602 0.727 rs11076837 chr16:4569440 C/T cg08645402 chr16:4508243 NA 0.53 8.37 0.46 3.34e-15 Schizophrenia; CESC cis rs10751667 0.666 rs10902247 chr11:953686 G/A cg01483505 chr11:975446 AP2A2 0.37 5.05 0.3 8.3e-7 Alzheimer's disease (late onset); CESC cis rs11168351 0.927 rs7971880 chr12:48391055 C/T cg04545296 chr12:48745243 ZNF641 0.35 6.04 0.35 5.16e-9 Bipolar disorder and schizophrenia; CESC cis rs10131894 0.611 rs174995 chr14:75434183 T/C cg11812906 chr14:75593930 NEK9 -0.67 -10.02 -0.52 3e-20 Coronary artery disease; CESC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg14262678 chr6:151773367 RMND1;C6orf211 0.66 9.44 0.5 2.04e-18 Menarche (age at onset); CESC trans rs2727020 0.590 rs7949936 chr11:49378902 G/A cg15704280 chr7:45808275 SEPT13 -0.78 -8.98 -0.48 5.13e-17 Coronary artery disease; CESC cis rs6448317 0.520 rs13116411 chr4:24928949 G/A cg21108841 chr4:24914750 CCDC149 -0.58 -8.16 -0.45 1.39e-14 Heschl's gyrus morphology; CESC cis rs8017423 0.647 rs12587362 chr14:90821227 G/T cg14092571 chr14:90743983 NA 0.43 6.5 0.37 3.92e-10 Mortality in heart failure; CESC cis rs7582720 1.000 rs72934745 chr2:203744454 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.48 0.42 1.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9815354 0.812 rs967619 chr3:41876710 C/G cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.84e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.66 -7.36 -0.41 2.36e-12 Gut microbiome composition (summer); CESC cis rs4481887 1.000 rs4916128 chr1:248466706 G/A cg00666640 chr1:248458726 OR2T12 0.39 6.37 0.36 8.47e-10 Common traits (Other); CESC cis rs34779708 0.931 rs12768019 chr10:35389843 T/C cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs17376456 0.825 rs74825443 chr5:93254973 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.65 5.32 0.31 2.22e-7 Diabetic retinopathy; CESC cis rs3780486 0.522 rs10217770 chr9:33146393 C/A cg13443165 chr9:33130375 B4GALT1 0.48 7.14 0.4 9.07e-12 IgG glycosylation; CESC cis rs6088580 0.634 rs6142164 chr20:33006597 C/T cg24642439 chr20:33292090 TP53INP2 -0.53 -7.01 -0.4 2.01e-11 Glomerular filtration rate (creatinine); CESC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg04518342 chr5:131593106 PDLIM4 0.4 6.17 0.35 2.6e-9 Breast cancer; CESC cis rs2637266 0.967 rs10400134 chr10:78365158 G/C cg18941641 chr10:78392320 NA 0.43 8.31 0.45 4.85e-15 Pulmonary function; CESC cis rs6540556 0.769 rs7521461 chr1:209926207 C/G cg05527609 chr1:210001259 C1orf107 -0.46 -5.66 -0.33 3.89e-8 Red blood cell count; CESC cis rs6456156 0.586 rs12527827 chr6:167469271 C/T cg23791538 chr6:167370224 RNASET2 -0.5 -6.47 -0.37 4.66e-10 Primary biliary cholangitis; CESC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg17971929 chr21:40555470 PSMG1 1.05 16.66 0.72 4.09e-43 Cognitive function; CESC cis rs55728055 0.661 rs1018488 chr22:31992376 A/G cg01338084 chr22:32026380 PISD 1.19 8.67 0.47 4.34e-16 Age-related hearing impairment; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26476595 chr16:2284284 E4F1 0.45 6.44 0.37 5.57e-10 Fibrinogen levels; CESC cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg00825309 chr19:58991885 ZNF446 -0.54 -7.71 -0.43 2.62e-13 Uric acid clearance; CESC cis rs4979906 1.000 rs11002248 chr10:79446961 A/G cg07817648 chr10:79422355 NA -0.47 -5.53 -0.32 7.61e-8 Mortality in heart failure; CESC cis rs8062405 1.000 rs4788101 chr16:28867804 C/T cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg16049864 chr8:95962084 TP53INP1 0.62 8.62 0.47 6.01e-16 Type 2 diabetes; CESC cis rs17209837 0.607 rs10452936 chr7:87094306 C/A cg00919237 chr7:87102261 ABCB4 -0.51 -6.58 -0.37 2.45e-10 Gallbladder cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24701867 chr1:1189640 UBE2J2 0.45 6.17 0.35 2.58e-9 Fibrinogen levels; CESC cis rs11642862 0.901 rs77604316 chr16:30921487 G/A cg02466173 chr16:30829666 NA -0.57 -5.22 -0.31 3.68e-7 Tonsillectomy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13108601 chr6:41748242 FRS3;PRICKLE4 0.57 7.53 0.42 8.1e-13 Gut microbiota (bacterial taxa); CESC trans rs13098911 0.540 rs34754340 chr3:46041837 C/T cg10236987 chr1:228114221 WNT9A 0.66 6.54 0.37 3.11e-10 Celiac disease; CESC cis rs2835872 0.758 rs7278101 chr21:39035873 T/C cg06728970 chr21:39037746 KCNJ6 -0.29 -5.18 -0.3 4.41e-7 Electroencephalographic traits in alcoholism; CESC cis rs473651 0.935 rs541013 chr2:239336492 G/A cg21699342 chr2:239360505 ASB1 0.53 8.61 0.47 6.85e-16 Multiple system atrophy; CESC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg11764359 chr7:65958608 NA -0.77 -10.96 -0.56 2.75e-23 Aortic root size; CESC cis rs2228479 0.557 rs62056064 chr16:89903843 G/A cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs6005807 0.543 rs6005868 chr22:29165766 T/C cg15103426 chr22:29168792 CCDC117 0.5 5.1 0.3 6.37e-7 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; CESC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg04772025 chr11:68637568 NA 0.52 6.37 0.36 8.42e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9372253 1.000 rs9386894 chr6:110718853 A/G cg19196401 chr6:110721138 DDO -0.38 -5.38 -0.31 1.64e-7 Platelet distribution width; CESC cis rs7107174 0.901 rs2511159 chr11:77974193 G/T cg02023728 chr11:77925099 USP35 -0.4 -5.84 -0.34 1.55e-8 Testicular germ cell tumor; CESC cis rs910316 0.737 rs91144 chr14:75449517 G/A cg11812906 chr14:75593930 NEK9 -0.82 -13.22 -0.63 5.34e-31 Height; CESC cis rs1595825 0.891 rs7584475 chr2:198577424 A/C cg00982548 chr2:198649783 BOLL -0.48 -5.15 -0.3 5.05e-7 Ulcerative colitis; CESC cis rs12477438 0.520 rs11123765 chr2:99768064 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.04 0.68 2.28e-37 Chronic sinus infection; CESC cis rs863345 0.526 rs2051666 chr1:158507160 T/G cg12129480 chr1:158549410 OR10X1 -0.35 -7.08 -0.4 1.32e-11 Pneumococcal bacteremia; CESC cis rs3096299 0.967 rs2965937 chr16:89488779 A/T cg02187348 chr16:89574699 SPG7 0.58 7.9 0.44 7.49e-14 Multiple myeloma (IgH translocation); CESC cis rs140365914 1 rs140365914 chr7:155106570 C/T cg14927855 chr7:155151427 NA 0.49 8.0 0.44 3.96e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3812831 0.643 rs7322339 chr13:114929726 C/A cg08824895 chr13:115047677 UPF3A 0.39 5.16 0.3 4.83e-7 Schizophrenia; CESC cis rs7772486 0.776 rs4316025 chr6:146238032 C/T cg05347473 chr6:146136440 FBXO30 -0.49 -6.45 -0.37 5.3e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2797160 1.000 rs2211419 chr6:125995533 C/T cg05901451 chr6:126070800 HEY2 0.43 6.37 0.36 8.39e-10 Endometrial cancer; CESC trans rs16949788 1.000 rs11071894 chr15:66773733 A/C cg10186254 chr14:80267501 NRXN3 -0.54 -6.02 -0.35 5.78e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs8044868 0.586 rs7199261 chr16:72082788 A/G cg16558253 chr16:72132732 DHX38 -0.4 -6.32 -0.36 1.12e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs2011503 0.941 rs7257875 chr19:19372150 C/T cg11584989 chr19:19387371 SF4 0.53 6.32 0.36 1.09e-9 Bipolar disorder; CESC cis rs9815354 1.000 rs28755797 chr3:41774446 C/T cg03022575 chr3:42003672 ULK4 0.53 5.22 0.31 3.61e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg26119090 chr2:26468346 HADHA;HADHB -1.06 -12.34 -0.6 5.85e-28 Gut microbiome composition (summer); CESC cis rs12464559 0.522 rs1916301 chr2:152640498 G/A cg01189475 chr2:152685088 ARL5A 0.72 7.08 0.4 1.29e-11 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs66887589 0.777 rs10015883 chr4:120268146 A/G cg09307838 chr4:120376055 NA 0.55 7.42 0.41 1.63e-12 Diastolic blood pressure; CESC cis rs7580658 0.895 rs9636237 chr2:128076022 T/C cg10021288 chr2:128175891 PROC -0.4 -6.41 -0.37 6.58e-10 Protein C levels; CESC cis rs1729951 0.575 rs16844326 chr3:136678385 G/C cg03617693 chr3:136751559 NA 0.38 5.31 0.31 2.27e-7 Neuroticism; CESC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg08859206 chr1:53392774 SCP2 0.72 11.25 0.57 2.95e-24 Monocyte count; CESC cis rs67311347 1.000 rs7648952 chr3:40457038 C/T cg09455208 chr3:40491958 NA -0.45 -7.91 -0.44 6.82e-14 Renal cell carcinoma; CESC cis rs4660306 1.000 rs7536557 chr1:45992114 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.5 -6.52 -0.37 3.49e-10 Homocysteine levels; CESC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.5 0.37 4.08e-10 Bipolar disorder; CESC cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg05347473 chr6:146136440 FBXO30 0.58 7.61 0.42 4.8e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg03433033 chr1:76189801 ACADM 0.66 7.69 0.43 2.84e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7116495 1.000 rs12272213 chr11:71816219 G/A cg26138937 chr11:71823887 C11orf51 0.85 6.85 0.39 5.03e-11 Severe influenza A (H1N1) infection; CESC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg18876405 chr7:65276391 NA -0.56 -6.12 -0.35 3.35e-9 Aortic root size; CESC cis rs6598955 0.543 rs6699798 chr1:26556442 G/T cg04990556 chr1:26633338 UBXN11 0.83 9.29 0.5 5.95e-18 Obesity-related traits; CESC cis rs8077889 0.719 rs57227660 chr17:41858984 T/C cg26893861 chr17:41843967 DUSP3 0.97 17.58 0.73 2.2e-46 Triglycerides; CESC cis rs9926296 0.533 rs12102290 chr16:89812617 C/T cg27121462 chr16:89883253 FANCA 0.82 12.28 0.6 9.91e-28 Vitiligo; CESC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg24549020 chr5:56110836 MAP3K1 0.65 7.56 0.42 6.72e-13 Initial pursuit acceleration; CESC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg03013636 chr16:1946785 NA -0.39 -5.27 -0.31 2.82e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs12912251 1.000 rs35024396 chr15:38989770 G/A cg01338139 chr15:38987640 C15orf53 -0.45 -5.28 -0.31 2.71e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs11030122 0.673 rs4910590 chr11:4018619 C/T cg18678763 chr11:4115507 RRM1 -0.48 -6.45 -0.37 5.42e-10 Mean platelet volume;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06603377 chr14:89629090 FOXN3 -0.63 -7.25 -0.41 4.45e-12 Gut microbiome composition (summer); CESC cis rs10899021 0.920 rs11236172 chr11:74330888 G/A cg25880958 chr11:74394337 NA -0.74 -7.91 -0.44 7.23e-14 Response to metformin (IC50); CESC cis rs1707322 0.964 rs785483 chr1:46559171 T/C cg03146154 chr1:46216737 IPP -0.69 -9.13 -0.49 1.84e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12142240 0.698 rs72677596 chr1:46833930 C/T cg10495392 chr1:46806563 NSUN4 0.58 6.07 0.35 4.34e-9 Menopause (age at onset); CESC cis rs3892630 0.878 rs8112955 chr19:33191192 C/T cg13157960 chr19:33183277 NUDT19 0.55 5.39 0.31 1.58e-7 Red blood cell traits; CESC cis rs4843747 0.636 rs4075597 chr16:88107590 C/A cg06374794 chr16:88002281 BANP 0.41 5.33 0.31 2.11e-7 Menopause (age at onset); CESC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg00684032 chr4:1343700 KIAA1530 0.6 9.13 0.49 1.79e-17 Obesity-related traits; CESC cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg12927641 chr6:109611667 NA -0.43 -6.63 -0.38 1.91e-10 Reticulocyte fraction of red cells; CESC cis rs9811920 0.666 rs793456 chr3:99525631 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.44 -7.11 -0.4 1.09e-11 Axial length; CESC cis rs2228479 0.850 rs17226498 chr16:89840631 T/C cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.55 -7.3 -0.41 3.27e-12 Menarche (age at onset); CESC cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC cis rs4268898 0.662 rs9784114 chr2:24437517 C/T cg06627628 chr2:24431161 ITSN2 -1.02 -11.2 -0.57 4.2e-24 Asthma; CESC cis rs950776 0.518 rs2869544 chr15:78839400 G/A cg06917634 chr15:78832804 PSMA4 -0.75 -11.31 -0.57 1.91e-24 Sudden cardiac arrest; CESC cis rs748404 0.631 rs7166812 chr15:43644760 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.78 0.43 1.6e-13 Lung cancer; CESC cis rs11645898 0.872 rs7206422 chr16:72152652 C/T cg14768367 chr16:72042858 DHODH -0.71 -6.03 -0.35 5.4e-9 Blood protein levels; CESC cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg24308560 chr3:49941425 MST1R 0.63 9.36 0.5 3.46e-18 Intelligence (multi-trait analysis); CESC cis rs7208859 0.623 rs7223209 chr17:29107220 C/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11843948 chr7:5410861 TNRC18 0.47 6.25 0.36 1.6e-9 Fibrinogen levels; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg24441975 chr1:39339062 MYCBP 0.45 6.22 0.36 1.95e-9 Bronchopulmonary dysplasia; CESC cis rs703842 0.642 rs10876994 chr12:58064737 A/C cg18357645 chr12:58087776 OS9 -0.56 -7.41 -0.41 1.68e-12 Multiple sclerosis; CESC cis rs7927592 0.913 rs948316 chr11:68309670 G/T cg20283391 chr11:68216788 NA -0.61 -7.36 -0.41 2.26e-12 Total body bone mineral density; CESC cis rs79349575 0.749 rs58838744 chr17:46998902 A/G cg26022315 chr17:47021804 SNF8 0.39 5.18 0.3 4.5e-7 Type 2 diabetes; CESC cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg07636037 chr3:49044803 WDR6 1.08 19.59 0.77 1.89e-53 Parkinson's disease; CESC cis rs9911578 1.000 rs391370 chr17:56675050 A/C cg12560992 chr17:57184187 TRIM37 0.93 15.64 0.69 1.66e-39 Intelligence (multi-trait analysis); CESC cis rs1055129 0.560 rs2666003 chr17:73942976 G/A cg08125733 chr17:73851984 WBP2 0.5 6.74 0.38 9.73e-11 White matter hyperintensity burden; CESC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg16049864 chr8:95962084 TP53INP1 -0.72 -13.04 -0.63 2.36e-30 Type 2 diabetes; CESC cis rs7927771 0.507 rs10838759 chr11:47785347 T/C cg20307385 chr11:47447363 PSMC3 0.61 8.64 0.47 5.37e-16 Subjective well-being; CESC cis rs6866344 0.697 rs6873150 chr5:178125704 G/A cg10224037 chr5:178157518 ZNF354A 0.62 6.96 0.39 2.72e-11 Neutrophil percentage of white cells; CESC cis rs7617773 0.539 rs13082217 chr3:48383264 T/C cg11946769 chr3:48343235 NME6 0.66 8.34 0.46 4.12e-15 Coronary artery disease; CESC cis rs2836974 0.931 rs2776309 chr21:40715791 A/G cg17971929 chr21:40555470 PSMG1 0.94 12.38 0.61 4.37e-28 Cognitive function; CESC cis rs2243480 1.000 rs316327 chr7:65609201 G/T cg13147721 chr7:65941812 NA 0.92 8.74 0.47 2.66e-16 Diabetic kidney disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13307718 chr11:85995223 NA -0.39 -6.63 -0.38 1.86e-10 Gambling; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg16727006 chr16:87470545 ZCCHC14 0.45 6.28 0.36 1.36e-9 Thyroid stimulating hormone; CESC cis rs7845219 0.544 rs2945554 chr8:95939594 C/A cg13393036 chr8:95962371 TP53INP1 -0.43 -8.02 -0.44 3.31e-14 Type 2 diabetes; CESC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg25985355 chr7:65971099 NA -0.33 -5.38 -0.31 1.62e-7 Aortic root size; CESC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -10.8 -0.55 9.11e-23 Initial pursuit acceleration; CESC cis rs14403 0.954 rs9803993 chr1:243672125 G/A cg21452805 chr1:244014465 NA 0.49 5.59 0.32 5.78e-8 Schizophrenia; CESC cis rs6963495 0.818 rs75116202 chr7:105160059 C/T cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.6 0.64 2.58e-32 Prudent dietary pattern; CESC cis rs6484504 0.553 rs2183484 chr11:31259370 G/A cg14844989 chr11:31128820 NA -0.41 -5.79 -0.34 1.96e-8 Red blood cell count; CESC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.2 0.4 6.31e-12 Bipolar disorder; CESC cis rs73206853 0.841 rs11065663 chr12:110988886 G/T cg12870014 chr12:110450643 ANKRD13A 0.58 5.24 0.31 3.25e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9916302 0.706 rs57933226 chr17:37412829 C/T cg07936489 chr17:37558343 FBXL20 -0.85 -9.92 -0.52 6.21e-20 Glomerular filtration rate (creatinine); CESC cis rs9916302 0.706 rs4795385 chr17:37733148 A/G cg20243544 chr17:37824526 PNMT -0.56 -5.47 -0.32 1.03e-7 Glomerular filtration rate (creatinine); CESC cis rs2274273 0.934 rs2341621 chr14:55726425 C/T cg04306507 chr14:55594613 LGALS3 0.3 5.86 0.34 1.34e-8 Protein biomarker; CESC cis rs11688816 0.904 rs2539984 chr2:63133584 G/C cg17519650 chr2:63277830 OTX1 0.41 5.63 0.33 4.67e-8 Body mass index; CESC cis rs10504229 0.639 rs112926738 chr8:58054939 A/G cg21724239 chr8:58056113 NA 0.52 5.05 0.3 8.08e-7 Developmental language disorder (linguistic errors); CESC cis rs9790314 1.000 rs1382428 chr3:161032386 A/C cg04691961 chr3:161091175 C3orf57 -0.43 -5.56 -0.32 6.47e-8 Morning vs. evening chronotype; CESC cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.78e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs11098499 0.615 rs28551750 chr4:120264901 C/T cg09307838 chr4:120376055 NA 0.75 9.88 0.52 8.38e-20 Corneal astigmatism; CESC cis rs1707322 0.963 rs12076580 chr1:46258159 G/A cg05343316 chr1:45956843 TESK2 0.51 6.25 0.36 1.59e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16011496 chr8:63057206 NA -0.56 -6.35 -0.36 9.22e-10 Gut microbiome composition (summer); CESC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg12373951 chr3:133503437 NA 0.37 5.52 0.32 8.2e-8 Iron status biomarkers; CESC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg07701084 chr6:150067640 NUP43 0.47 6.67 0.38 1.46e-10 Lung cancer; CESC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7772486 0.754 rs702323 chr6:146008274 A/G cg23711669 chr6:146136114 FBXO30 -0.87 -12.26 -0.6 1.14e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.6 0.42 5.08e-13 Prudent dietary pattern; CESC cis rs4689388 0.679 rs1046316 chr4:6304087 A/G cg25554036 chr4:6271136 WFS1 0.51 7.68 0.43 3.15e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07738938 chr7:5372608 TNRC18 0.51 7.02 0.4 1.81e-11 Fibrinogen levels; CESC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.78 0.38 7.85e-11 Platelet count; CESC cis rs2502731 0.561 rs3003606 chr9:130982416 C/T cg13642260 chr9:130955380 CIZ1 0.45 6.58 0.37 2.46e-10 Attention deficit hyperactivity disorder; CESC cis rs6582630 0.519 rs7294292 chr12:38349540 C/T cg26384229 chr12:38710491 ALG10B 0.73 10.95 0.56 2.81e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs4843747 0.518 rs4072777 chr16:88107030 G/A cg03395651 chr16:88107091 BANP 0.46 5.36 0.31 1.85e-7 Menopause (age at onset); CESC cis rs2354432 0.556 rs72710311 chr1:146698256 A/G cg25205988 chr1:146714368 CHD1L -1.02 -8.03 -0.44 3.16e-14 Mitochondrial DNA levels; CESC cis rs6543140 0.964 rs2310301 chr2:103072935 C/T cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs9790314 0.967 rs10804790 chr3:161039300 T/A cg03342759 chr3:160939853 NMD3 -0.48 -6.25 -0.36 1.61e-9 Morning vs. evening chronotype; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09158336 chr17:76338205 NA -0.45 -6.03 -0.35 5.58e-9 Ulcerative colitis; CESC cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.4 0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg26039829 chr8:22132926 PIWIL2 0.39 6.05 0.35 4.84e-9 Hypertriglyceridemia; CESC cis rs7130144 0.541 rs73572219 chr11:130459830 C/T cg26307797 chr11:130446613 NA -0.74 -6.36 -0.36 8.72e-10 Urate levels in lean individuals; CESC cis rs17021463 0.966 rs7657789 chr4:95178589 C/T cg11021082 chr4:95130006 SMARCAD1 -0.68 -11.15 -0.57 6.32e-24 Testicular germ cell tumor; CESC cis rs2295359 1.000 rs4655684 chr1:67611772 A/G cg03340356 chr1:67600835 NA -0.33 -5.64 -0.33 4.39e-8 Psoriasis; CESC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.3 -0.5 5.54e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12472274 0.646 rs10929269 chr2:239097423 A/G cg17459225 chr2:239074497 NA 0.51 5.95 0.34 8.6e-9 Phospholipid levels (plasma); CESC cis rs2303759 0.543 rs7255778 chr19:49906608 G/A cg24324837 chr19:49891574 CCDC155 0.43 5.06 0.3 7.85e-7 Multiple sclerosis; CESC cis rs10870270 0.956 rs7904594 chr10:133734671 C/T cg26149184 chr10:133730230 NA 0.38 5.15 0.3 5.07e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg06074448 chr4:187884817 NA -0.37 -5.43 -0.32 1.27e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs1387259 0.931 rs1107654 chr12:48681097 T/G cg04545296 chr12:48745243 ZNF641 0.42 7.06 0.4 1.47e-11 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs920590 0.758 rs62496731 chr8:19659543 C/G cg03894339 chr8:19674705 INTS10 0.64 7.32 0.41 3e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs4629180 0.586 rs10172555 chr2:102126837 C/T cg04415270 chr2:102091202 RFX8 -0.3 -5.22 -0.31 3.53e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs6493487 0.512 rs8024689 chr15:51129127 C/T cg02338191 chr15:51200825 AP4E1 0.51 5.18 0.3 4.4e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7246657 0.943 rs8106839 chr19:37958475 C/G cg23950597 chr19:37808831 NA -0.58 -6.3 -0.36 1.22e-9 Coronary artery calcification; CESC cis rs9811920 0.609 rs4928232 chr3:99694217 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.63 -9.86 -0.52 9.59e-20 Axial length; CESC cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg12386194 chr3:101231763 SENP7 0.41 5.04 0.3 8.5e-7 Colorectal cancer; CESC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg03188948 chr7:1209495 NA 0.53 6.08 0.35 4.28e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg26338869 chr17:61819248 STRADA 0.67 8.79 0.48 1.9e-16 Prudent dietary pattern; CESC cis rs4664308 0.505 rs1037694 chr2:161028992 A/G cg03641300 chr2:160917029 PLA2R1 -0.37 -5.38 -0.31 1.65e-7 Idiopathic membranous nephropathy; CESC cis rs8008758 0.517 rs1772024 chr14:101695220 A/C cg26224664 chr14:101693935 NA 0.41 7.55 0.42 7.15e-13 Body mass index (alcohol intake interaction); CESC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg00684032 chr4:1343700 KIAA1530 0.37 5.54 0.32 7.28e-8 Obesity-related traits; CESC cis rs854765 0.547 rs6502632 chr17:17913057 A/G cg16928487 chr17:17741425 SREBF1 -0.55 -9.43 -0.5 2.18e-18 Total body bone mineral density; CESC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg18252515 chr7:66147081 NA 0.41 5.28 0.31 2.73e-7 Aortic root size; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg18591801 chr3:52553433 STAB1 -0.29 -5.59 -0.32 5.66e-8 Electroencephalogram traits; CESC trans rs561341 0.941 rs550213 chr17:30317518 C/G cg27661571 chr11:113659931 NA -0.71 -7.38 -0.41 1.99e-12 Hip circumference adjusted for BMI; CESC cis rs113835537 0.597 rs10896129 chr11:66338300 T/C cg24851651 chr11:66362959 CCS 0.5 5.96 0.34 7.95e-9 Airway imaging phenotypes; CESC cis rs1707322 1.000 rs10890359 chr1:46336635 A/G cg03146154 chr1:46216737 IPP 0.74 10.16 0.53 1.08e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg07648498 chr16:89883185 FANCA 0.44 5.42 0.32 1.34e-7 Vitiligo; CESC cis rs7927592 0.763 rs2513277 chr11:68360887 T/G cg16797656 chr11:68205561 LRP5 0.48 7.1 0.4 1.18e-11 Total body bone mineral density; CESC cis rs6088580 0.713 rs1884669 chr20:33171287 G/A cg08999081 chr20:33150536 PIGU 0.72 12.82 0.62 1.3e-29 Glomerular filtration rate (creatinine); CESC cis rs2197308 0.703 rs10880251 chr12:37903297 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.76 0.38 8.79e-11 Morning vs. evening chronotype; CESC cis rs2625529 0.617 rs8025939 chr15:72460339 T/A cg16672083 chr15:72433130 SENP8 0.49 7.33 0.41 2.81e-12 Red blood cell count; CESC cis rs727505 0.954 rs68102397 chr7:124685315 C/T cg23710748 chr7:124431027 NA -0.41 -6.4 -0.37 6.92e-10 Lewy body disease; CESC cis rs12995849 0.714 rs7580718 chr2:106471327 C/A cg16077055 chr2:106428750 NCK2 0.4 5.93 0.34 9.52e-9 Addiction; CESC cis rs7618501 1.000 rs2271960 chr3:49878078 A/G cg24308560 chr3:49941425 MST1R -0.49 -6.38 -0.36 7.99e-10 Intelligence (multi-trait analysis); CESC cis rs642803 0.551 rs1308020 chr11:65497558 G/A cg08755490 chr11:65554678 OVOL1 0.44 5.62 0.33 4.92e-8 Urate levels; CESC cis rs10129255 0.500 rs988132 chr14:107184997 C/T cg07958169 chr14:107095056 NA -0.52 -8.02 -0.44 3.42e-14 Kawasaki disease; CESC cis rs9916302 0.861 rs11078896 chr17:37415544 C/T cg20243544 chr17:37824526 PNMT 0.47 5.87 0.34 1.27e-8 Glomerular filtration rate (creatinine); CESC cis rs6032067 0.929 rs6017513 chr20:43835232 A/C cg11264863 chr20:43835661 SEMG1 0.48 5.26 0.31 2.99e-7 Blood protein levels; CESC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg26343298 chr8:95960752 TP53INP1 0.36 5.98 0.34 7.06e-9 Type 2 diabetes; CESC cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC trans rs1557351 0.723 rs9953564 chr18:54720196 G/A cg11433624 chr6:7146702 RREB1 0.39 6.27 0.36 1.47e-9 Multiple sclerosis (age of onset); CESC cis rs909002 0.849 rs1464306 chr1:32076261 T/C cg13919466 chr1:32135498 COL16A1 -0.48 -8.47 -0.46 1.66e-15 Intelligence (multi-trait analysis); CESC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg14893161 chr1:205819251 PM20D1 0.48 6.91 0.39 3.69e-11 Prostate cancer; CESC cis rs7044106 0.762 rs10984972 chr9:123409864 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.46 0.54 1.15e-21 Hip circumference adjusted for BMI; CESC cis rs2180341 0.920 rs1073931 chr6:127681762 A/T cg24812749 chr6:127587940 RNF146 1.05 15.15 0.68 9.37e-38 Breast cancer; CESC cis rs11583043 1.000 rs7535068 chr1:101490329 T/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.63 0.33 4.65e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg17650747 chr5:1873721 NA 0.43 6.09 0.35 3.94e-9 Cardiovascular disease risk factors; CESC cis rs6541297 0.703 rs650808 chr1:230317820 G/A cg20703242 chr1:230279135 GALNT2 -0.44 -5.77 -0.33 2.27e-8 Coronary artery disease; CESC cis rs6693567 0.565 rs11205370 chr1:150397567 A/G cg09579323 chr1:150459698 TARS2 0.48 6.07 0.35 4.38e-9 Migraine; CESC cis rs35110281 0.508 rs2838351 chr21:45110784 A/G cg01579765 chr21:45077557 HSF2BP -0.5 -7.98 -0.44 4.37e-14 Mean corpuscular volume; CESC cis rs3091242 0.836 rs34997029 chr1:25783823 A/G cg02931644 chr1:25747376 RHCE -0.43 -7.19 -0.4 6.66e-12 Erythrocyte sedimentation rate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13760347 chr22:42343277 CENPM -0.43 -6.26 -0.36 1.53e-9 Gambling; CESC cis rs10779751 0.734 rs2261217 chr1:11127764 C/A cg08854313 chr1:11322531 MTOR 0.77 10.41 0.54 1.73e-21 Body mass index; CESC cis rs10504229 0.679 rs16921687 chr8:58053514 T/C cg22535103 chr8:58192502 C8orf71 -0.65 -7.25 -0.41 4.69e-12 Developmental language disorder (linguistic errors); CESC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg11644478 chr21:40555479 PSMG1 -0.51 -6.94 -0.39 3.01e-11 Menarche (age at onset); CESC cis rs3008870 1.000 rs2755245 chr1:67487964 C/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 14.2 0.66 2.05e-34 Lymphocyte percentage of white cells; CESC cis rs7762018 1.000 rs41265383 chr6:170068025 T/C cg05834625 chr6:170176447 C6orf70 0.62 7.35 0.41 2.48e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1005224 0.963 rs11623813 chr14:76138194 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.42 -5.81 -0.34 1.81e-8 Large artery stroke; CESC cis rs1559088 0.803 rs10411529 chr19:33616256 A/C cg27124370 chr19:33622961 WDR88 0.42 5.48 0.32 1e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23214166 chr1:26606872 SH3BGRL3 0.55 6.19 0.36 2.34e-9 Gut microbiome composition (summer); CESC cis rs11122272 0.615 rs1465740 chr1:231495255 T/A cg06096015 chr1:231504339 EGLN1 0.46 6.65 0.38 1.7e-10 Hemoglobin concentration; CESC cis rs4523957 0.620 rs9900587 chr17:2071097 G/A cg16513277 chr17:2031491 SMG6 -0.77 -11.2 -0.57 4.15e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2652822 0.525 rs58789072 chr15:63497553 G/A cg02713581 chr15:63449717 RPS27L 0.49 6.39 0.37 7.59e-10 Metabolic traits; CESC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg08470875 chr2:26401718 FAM59B -0.7 -7.42 -0.41 1.55e-12 Gut microbiome composition (summer); CESC cis rs656900 0.647 rs668641 chr15:80118624 C/T cg02196730 chr15:80188777 MTHFS -0.4 -5.29 -0.31 2.52e-7 Cerebrospinal P-tau181p levels; CESC cis rs2337406 0.500 rs57619050 chr14:107228305 G/A cg07958169 chr14:107095056 NA -0.46 -5.09 -0.3 6.91e-7 Alzheimer's disease (late onset); CESC cis rs7917772 0.582 rs10883753 chr10:104372441 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.39 5.35 0.31 1.86e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg12641515 chr19:46296257 DMWD 0.74 9.95 0.52 4.96e-20 Coronary artery disease; CESC cis rs4253772 0.515 rs8142080 chr22:46647429 G/T cg24881330 chr22:46731750 TRMU 0.82 6.49 0.37 4.09e-10 LDL cholesterol;Cholesterol, total; CESC cis rs3771570 1.000 rs73002147 chr2:242302934 T/C cg21155796 chr2:242212141 HDLBP 0.6 5.27 0.31 2.89e-7 Prostate cancer; CESC cis rs2115536 1.000 rs2115540 chr15:80190308 A/G cg00225070 chr15:80189496 MTHFS 0.6 8.42 0.46 2.33e-15 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs734999 0.505 rs10797439 chr1:2540364 G/A cg20673091 chr1:2541236 MMEL1 0.45 7.84 0.43 1.09e-13 Ulcerative colitis; CESC cis rs2243480 0.901 rs3813708 chr7:65305632 C/A cg12463550 chr7:65579703 CRCP 0.7 5.55 0.32 6.85e-8 Diabetic kidney disease; CESC cis rs3096299 0.874 rs3102342 chr16:89451575 T/C cg08822215 chr16:89438651 ANKRD11 -0.37 -5.58 -0.32 5.87e-8 Multiple myeloma (IgH translocation); CESC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg20887711 chr4:1340912 KIAA1530 -0.87 -11.81 -0.59 3.71e-26 Longevity; CESC cis rs1005277 0.557 rs2983338 chr10:38550734 C/T cg00409905 chr10:38381863 ZNF37A -0.49 -6.58 -0.37 2.54e-10 Extrinsic epigenetic age acceleration; CESC cis rs9457247 1.000 rs439553 chr6:167391212 A/G cg25258033 chr6:167368657 RNASET2 0.41 6.13 0.35 3.23e-9 Crohn's disease; CESC cis rs7605827 0.930 rs2003592 chr2:15552153 C/T cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.42e-9 Educational attainment (years of education); CESC cis rs12681288 0.823 rs2701909 chr8:1003057 A/G cg15309053 chr8:964076 NA 0.35 6.09 0.35 3.99e-9 Schizophrenia; CESC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg11764359 chr7:65958608 NA 0.66 8.45 0.46 1.95e-15 Aortic root size; CESC trans rs4950322 0.580 rs7514970 chr1:146592098 C/T cg04954894 chr8:38089920 DDHD2 -0.59 -6.43 -0.37 5.98e-10 Protein quantitative trait loci; CESC cis rs2370759 1.000 rs11008865 chr10:32574842 C/T cg01819863 chr10:32635814 EPC1 1.17 13.3 0.63 2.82e-31 Sexual dysfunction (female); CESC cis rs11785693 0.862 rs7007542 chr8:4996718 G/A cg26367366 chr8:4980734 NA 0.83 7.83 0.43 1.16e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg19468946 chr17:37922297 IKZF3 0.4 5.17 0.3 4.69e-7 Glomerular filtration rate (creatinine); CESC cis rs863345 0.967 rs6697568 chr1:158520466 T/G cg12129480 chr1:158549410 OR10X1 -0.33 -6.48 -0.37 4.53e-10 Pneumococcal bacteremia; CESC cis rs10949834 0.817 rs6460071 chr7:73497196 G/A cg07137043 chr7:73588983 EIF4H -0.69 -6.89 -0.39 4.1e-11 Verbal memory performance (residualized delayed recall change); CESC cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg19901468 chr14:105411992 AHNAK2 -0.6 -8.78 -0.47 2.07e-16 Rheumatoid arthritis; CESC cis rs7666738 0.719 rs35184673 chr4:99050945 T/C cg03676636 chr4:99064102 C4orf37 0.44 5.33 0.31 2.11e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3768617 0.510 rs3768616 chr1:183103551 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 13.27 0.63 3.59e-31 Fuchs's corneal dystrophy; CESC cis rs6460942 0.591 rs62448733 chr7:12350526 C/T cg20607287 chr7:12443886 VWDE -0.61 -6.7 -0.38 1.23e-10 Coronary artery disease; CESC cis rs6991838 0.584 rs3812412 chr8:66547092 G/A cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs3808502 0.605 rs11784572 chr8:11174484 C/G cg21775007 chr8:11205619 TDH -0.44 -5.93 -0.34 9.39e-9 Neuroticism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12738349 chr22:24236284 MIF -0.44 -6.46 -0.37 4.91e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6088590 0.648 rs6059991 chr20:33280836 C/T cg24642439 chr20:33292090 TP53INP2 0.73 9.68 0.51 3.57e-19 Coronary artery disease; CESC trans rs4756846 1.000 rs4756846 chr11:16403511 C/T cg05579622 chr5:10618622 ANKRD33B -0.77 -7.03 -0.4 1.78e-11 Obesity and osteoporosis; CESC cis rs4268898 0.610 rs55860688 chr2:24451534 T/C cg20701182 chr2:24300061 SF3B14 0.65 6.96 0.39 2.59e-11 Asthma; CESC cis rs1620921 0.505 rs9458031 chr6:161210119 G/A cg01280913 chr6:161186852 NA -0.39 -5.63 -0.33 4.7e-8 Lipoprotein (a) - cholesterol levels; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg01217204 chr2:113239325 TTL 0.51 6.55 0.37 2.98e-10 Thyroid stimulating hormone; CESC cis rs9905704 0.918 rs302868 chr17:56752123 C/T cg12560992 chr17:57184187 TRIM37 0.59 6.95 0.39 2.75e-11 Testicular germ cell tumor; CESC cis rs727505 1.000 rs6952721 chr7:124480075 T/C cg23710748 chr7:124431027 NA -0.39 -6.4 -0.37 7e-10 Lewy body disease; CESC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg13206674 chr6:150067644 NUP43 0.41 5.72 0.33 2.82e-8 Lung cancer; CESC cis rs57502260 0.749 rs67446678 chr11:68227466 C/T cg20283391 chr11:68216788 NA -0.64 -5.5 -0.32 9.07e-8 Total body bone mineral density (age 45-60); CESC cis rs9287719 0.967 rs4669598 chr2:10757838 T/C cg02196655 chr2:10830764 NOL10 -0.37 -5.67 -0.33 3.73e-8 Prostate cancer; CESC cis rs1355223 0.902 rs2226113 chr11:34746289 C/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.46 -0.37 5.03e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2070488 1.000 rs1002675 chr3:38445226 C/T cg24069376 chr3:38537580 EXOG 0.45 8.15 0.45 1.43e-14 Electrocardiographic conduction measures; CESC trans rs62103177 0.810 rs62103195 chr18:77629693 T/C cg05926928 chr17:57297772 GDPD1 1.23 10.47 0.54 1.11e-21 Opioid sensitivity; CESC cis rs7927592 0.956 rs12274114 chr11:68255577 A/C cg16797656 chr11:68205561 LRP5 0.41 5.75 0.33 2.51e-8 Total body bone mineral density; CESC cis rs2404602 0.684 rs11854850 chr15:76844571 C/T cg23625390 chr15:77176239 SCAPER -0.43 -5.91 -0.34 1.06e-8 Blood metabolite levels; CESC cis rs7621025 0.599 rs13063987 chr3:136445397 C/G cg15507776 chr3:136538369 TMEM22 -0.54 -6.08 -0.35 4.18e-9 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs1153858 1.000 rs59889118 chr15:45618730 G/A cg21132104 chr15:45694354 SPATA5L1 0.83 11.01 0.56 1.85e-23 Homoarginine levels; CESC cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg02187348 chr16:89574699 SPG7 0.52 6.83 0.39 5.96e-11 Multiple myeloma (IgH translocation); CESC cis rs73001065 0.636 rs73002960 chr19:19582992 C/T cg03709012 chr19:19516395 GATAD2A 0.97 6.99 0.39 2.21e-11 LDL cholesterol; CESC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg00149659 chr3:10157352 C3orf10 0.54 6.64 0.38 1.72e-10 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07450219 chr17:78428858 NA 0.63 7.04 0.4 1.61e-11 Gut microbiome composition (summer); CESC cis rs2354432 0.607 rs6685775 chr1:146744294 A/G cg25205988 chr1:146714368 CHD1L -0.9 -7.78 -0.43 1.64e-13 Mitochondrial DNA levels; CESC cis rs2354432 0.607 rs6658763 chr1:146692373 C/T cg25205988 chr1:146714368 CHD1L -1.01 -7.32 -0.41 2.91e-12 Mitochondrial DNA levels; CESC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.6 0.51 6.43e-19 Platelet count; CESC cis rs4979906 1.000 rs4979906 chr10:79444753 A/G cg07817648 chr10:79422355 NA -0.47 -5.53 -0.32 7.81e-8 Mortality in heart failure; CESC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.54 0.42 7.72e-13 Bipolar disorder; CESC cis rs9814567 1.000 rs62269547 chr3:134214042 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.99 -0.35 6.9e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs17125944 0.773 rs1952089 chr14:53339777 C/T cg01134794 chr4:78529898 CXCL13 0.53 6.01 0.35 6.22e-9 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19111906 chr11:67816846 TCIRG1 -0.47 -6.16 -0.35 2.62e-9 Gut microbiome composition (summer); CESC cis rs826838 0.834 rs2387842 chr12:38736442 T/C cg13010199 chr12:38710504 ALG10B 0.62 8.72 0.47 3.22e-16 Heart rate; CESC cis rs2370759 1.000 rs76998371 chr10:32631785 A/G cg01819863 chr10:32635814 EPC1 1.16 12.73 0.62 2.71e-29 Sexual dysfunction (female); CESC cis rs11098499 0.754 rs2036856 chr4:120249288 G/A cg09307838 chr4:120376055 NA 0.77 10.35 0.54 2.54e-21 Corneal astigmatism; CESC cis rs546131 0.928 rs552171 chr11:34830709 G/T cg11058730 chr11:34937778 PDHX;APIP 0.47 5.84 0.34 1.52e-8 Lung disease severity in cystic fibrosis; CESC trans rs877282 0.583 rs11595057 chr10:819203 A/C cg22713356 chr15:30763199 NA 1.01 9.48 0.5 1.47e-18 Uric acid levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06683288 chr20:60813424 OSBPL2 -0.38 -6.06 -0.35 4.67e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21207217 chr5:43484130 C5orf28 -0.63 -6.74 -0.38 9.89e-11 Gut microbiome composition (summer); CESC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg02187348 chr16:89574699 SPG7 0.7 9.92 0.52 6.38e-20 Multiple myeloma (IgH translocation); CESC cis rs12762955 0.608 rs7922760 chr10:1156815 G/C cg18964960 chr10:1102726 WDR37 -0.56 -6.33 -0.36 1.02e-9 Response to angiotensin II receptor blocker therapy; CESC cis rs7208859 0.623 rs73269988 chr17:29118145 G/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg03609598 chr5:56110824 MAP3K1 -0.53 -5.61 -0.33 5.2100000000000003e-08 Initial pursuit acceleration; CESC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.65 0.64 1.8e-32 Prudent dietary pattern; CESC cis rs7949030 0.653 rs2516634 chr11:62367186 G/A cg11742103 chr11:62369870 EML3;MTA2 -0.6 -9.13 -0.49 1.86e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg17971929 chr21:40555470 PSMG1 -0.99 -15.24 -0.68 4.33e-38 Cognitive function; CESC cis rs9303401 0.659 rs1864754 chr17:56688789 G/T cg10487724 chr17:56770010 TEX14;RAD51C -1.05 -13.18 -0.63 7.78e-31 Cognitive test performance; CESC cis rs34779708 0.931 rs79749947 chr10:35277081 A/T cg04310649 chr10:35416472 CREM -0.5 -5.97 -0.34 7.61e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs7246657 0.943 rs10414904 chr19:37830088 G/A cg24637308 chr11:6592297 DNHD1 0.53 6.17 0.35 2.55e-9 Coronary artery calcification; CESC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg05863683 chr7:1912471 MAD1L1 0.4 5.9 0.34 1.08e-8 Bipolar disorder and schizophrenia; CESC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg18404041 chr3:52824283 ITIH1 -0.49 -7.9 -0.44 7.26e-14 Bipolar disorder; CESC cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg27347728 chr4:17578864 LAP3 -0.45 -5.26 -0.31 3e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9322193 0.516 rs1999632 chr6:150187873 C/T cg01145232 chr6:150245071 RAET1G 0.48 6.07 0.35 4.48e-9 Lung cancer; CESC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.52 0.54 7.61e-22 Prudent dietary pattern; CESC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.18 0.3 4.29e-7 Lung cancer; CESC cis rs9303401 0.704 rs7359501 chr17:56641200 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.54 7.24 0.41 4.92e-12 Cognitive test performance; CESC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs7818688 0.654 rs75680386 chr8:95986148 A/G cg16049864 chr8:95962084 TP53INP1 0.56 5.62 0.33 4.74e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.55 7.39 0.41 1.92e-12 Bone mineral density (hip);Bone mineral density; CESC cis rs7927771 0.524 rs4752796 chr11:47841862 A/G cg20307385 chr11:47447363 PSMC3 -0.58 -8.03 -0.44 3.12e-14 Subjective well-being; CESC cis rs12476592 0.543 rs12713494 chr2:63698162 G/T cg17519650 chr2:63277830 OTX1 -0.47 -5.23 -0.31 3.41e-7 Childhood ear infection; CESC cis rs7267979 0.933 rs6138571 chr20:25435388 A/G cg08601574 chr20:25228251 PYGB 0.37 5.31 0.31 2.31e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2299587 0.897 rs3850745 chr8:17784277 G/A cg08627089 chr8:17753878 FGL1 -0.36 -5.04 -0.3 8.69e-7 Economic and political preferences; CESC cis rs1865760 0.566 rs9366634 chr6:26072396 C/G cg17691542 chr6:26056736 HIST1H1C 0.41 5.47 0.32 1.05e-7 Height; CESC trans rs163030 0.840 rs335611 chr5:76747860 T/C cg26150533 chr8:82396069 FABP4 -0.39 -6.0 -0.35 6.54e-9 Caudate nucleus volume; CESC cis rs3096299 0.967 rs11648663 chr16:89466307 C/T cg08822215 chr16:89438651 ANKRD11 -0.42 -6.47 -0.37 4.58e-10 Multiple myeloma (IgH translocation); CESC cis rs11792861 0.816 rs11788336 chr9:111688387 T/C cg05043794 chr9:111880884 C9orf5 -0.37 -6.11 -0.35 3.59e-9 Menarche (age at onset); CESC cis rs17039065 0.920 rs73838435 chr4:109445261 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.66 6.18 0.35 2.47e-9 Gut microbiome composition (summer); CESC cis rs1577917 1.000 rs12208493 chr6:86662267 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.08 -0.35 4.29e-9 Response to antipsychotic treatment; CESC cis rs9300255 0.596 rs1568427 chr12:123738678 A/G cg19016782 chr12:123741754 C12orf65 -0.37 -5.61 -0.33 5.17e-8 Neutrophil percentage of white cells; CESC cis rs10463316 0.894 rs6579864 chr5:150762181 G/A cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC cis rs7560272 0.723 rs780395 chr2:73700853 G/A cg20560298 chr2:73613845 ALMS1 0.49 7.1 0.4 1.14e-11 Schizophrenia; CESC cis rs4727027 0.901 rs4727017 chr7:148822062 A/G cg23158103 chr7:148848205 ZNF398 -0.41 -6.74 -0.38 9.65e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg03806693 chr22:41940476 POLR3H -1.22 -16.24 -0.71 1.23e-41 Vitiligo; CESC cis rs8070128 0.583 rs7406982 chr17:17942613 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.33 0.36 1.03e-9 Total body bone mineral density; CESC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.52 0.37 3.63e-10 Prudent dietary pattern; CESC cis rs782590 0.869 rs782599 chr2:55847423 C/T cg18811423 chr2:55921094 PNPT1 0.79 12.22 0.6 1.55e-27 Metabolic syndrome; CESC cis rs1941023 0.503 rs12798266 chr11:60118851 G/A cg08716584 chr11:60157161 MS4A7 -0.5 -8.03 -0.44 3.19e-14 Congenital heart disease (maternal effect); CESC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg06074448 chr4:187884817 NA -0.37 -5.3 -0.31 2.41e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg08470875 chr2:26401718 FAM59B -0.63 -6.69 -0.38 1.33e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs3785279 chr16:89824562 G/C cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.34e-11 Skin colour saturation; CESC cis rs9300255 0.602 rs1716165 chr12:123648881 C/T cg19016782 chr12:123741754 C12orf65 -0.4 -5.77 -0.33 2.27e-8 Neutrophil percentage of white cells; CESC trans rs74054849 0.850 rs72878865 chr1:16009097 G/A cg06826283 chr7:600452 PRKAR1B 0.7 6.26 0.36 1.55e-9 Alcoholic chronic pancreatitis; CESC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg12963246 chr6:28129442 ZNF389 0.51 7.16 0.4 8.11e-12 Depression; CESC cis rs3820068 0.603 rs2236215 chr1:15892415 A/C cg17385448 chr1:15911702 AGMAT 0.39 6.35 0.36 9.13e-10 Systolic blood pressure; CESC cis rs6741892 0.536 rs7590835 chr2:38893950 A/G cg05604112 chr2:38893237 GALM 0.55 7.59 0.42 5.44e-13 5-HTT brain serotonin transporter levels; CESC trans rs2727020 0.617 rs1917311 chr11:49422665 C/T cg15704280 chr7:45808275 SEPT13 -0.89 -15.13 -0.68 1.09e-37 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22395253 chr7:104941898 SRPK2 -0.57 -6.01 -0.35 6.13e-9 Gut microbiome composition (summer); CESC cis rs72945132 0.882 rs72949076 chr11:70217695 T/C cg00319359 chr11:70116639 PPFIA1 0.76 7.17 0.4 7.33e-12 Coronary artery disease; CESC cis rs9916302 0.752 rs11078895 chr17:37401051 A/G cg07936489 chr17:37558343 FBXL20 -0.98 -11.85 -0.59 2.79e-26 Glomerular filtration rate (creatinine); CESC cis rs7107174 1.000 rs7939352 chr11:78003151 G/A cg02023728 chr11:77925099 USP35 0.41 5.97 0.34 7.43e-9 Testicular germ cell tumor; CESC cis rs7085104 0.684 rs7092690 chr10:104609365 T/C cg15744005 chr10:104629667 AS3MT -0.37 -5.8 -0.34 1.84e-8 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs28374715 0.532 rs11854632 chr15:41682094 A/G cg02330683 chr15:41787940 ITPKA -0.42 -5.21 -0.3 3.85e-7 Ulcerative colitis; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg12857786 chr4:83934023 LIN54 -0.44 -6.15 -0.35 2.77e-9 Vertical cup-disc ratio; CESC cis rs2072438 0.503 rs2146838 chr9:123876305 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.37 -5.39 -0.31 1.58e-7 Rheumatoid arthritis; CESC cis rs17826219 0.636 rs8080829 chr17:29058730 C/T cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Body mass index; CESC cis rs3540 0.554 rs113942266 chr15:91072990 A/G cg10434728 chr15:90938212 IQGAP1 -0.41 -7.42 -0.41 1.57e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03951724 chr22:30723125 TBC1D10A 0.62 7.5 0.42 9.53e-13 Gut microbiome composition (summer); CESC cis rs4588572 0.602 rs10059672 chr5:77673317 G/C cg11547950 chr5:77652471 NA 0.46 5.85 0.34 1.44e-8 Triglycerides; CESC cis rs9902453 0.904 rs10853136 chr17:28406018 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -9.1 -0.49 2.24e-17 Coffee consumption (cups per day); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01553063 chr11:560751 RASSF7;C11orf35 -0.47 -6.02 -0.35 5.8e-9 Gut microbiota (bacterial taxa); CESC cis rs17376456 0.809 rs13177800 chr5:93307350 T/C cg21475434 chr5:93447410 FAM172A 0.8 6.94 0.39 2.95e-11 Diabetic retinopathy; CESC cis rs10089 1.000 rs4836369 chr5:127486462 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.51 0.54 8.08e-22 Ileal carcinoids; CESC cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.4 0.41 1.78e-12 Tonsillectomy; CESC cis rs7727544 0.684 rs2631363 chr5:131707095 A/G cg24060327 chr5:131705240 SLC22A5 0.63 8.33 0.46 4.43e-15 Blood metabolite levels; CESC cis rs12681366 0.734 rs16916796 chr8:95402229 A/G cg13257157 chr8:95487014 RAD54B 0.38 5.14 0.3 5.22e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03145290 chr16:32857923 NA 0.37 6.04 0.35 5.18e-9 Fibrinogen levels; CESC cis rs12545109 0.837 rs4738500 chr8:57356193 G/A cg09654669 chr8:57350985 NA -0.6 -6.98 -0.39 2.44e-11 Obesity-related traits; CESC cis rs67311347 0.955 rs4974068 chr3:40376929 T/C cg24209194 chr3:40518798 ZNF619 0.41 5.24 0.31 3.3e-7 Renal cell carcinoma; CESC cis rs75477785 1.000 rs12075674 chr1:209995470 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.86 5.44 0.32 1.2e-7 Cleft lip with or without cleft palate; CESC trans rs7937682 0.824 rs11213962 chr11:111506027 G/A cg18187862 chr3:45730750 SACM1L 0.51 6.47 0.37 4.81e-10 Primary sclerosing cholangitis; CESC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.09 21.15 0.79 7.85e-59 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08205843 chr19:12848293 ASNA1 -0.66 -8.05 -0.44 2.87e-14 Gut microbiome composition (summer); CESC trans rs7615952 0.641 rs6438951 chr3:125696999 A/G cg07211511 chr3:129823064 LOC729375 -0.58 -6.62 -0.38 1.96e-10 Blood pressure (smoking interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00949670 chr12:120967105 COQ5 -0.47 -6.2 -0.36 2.11e-9 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07512676 chr17:48785330 ANKRD40 0.42 6.1 0.35 3.75e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6540556 0.723 rs6540551 chr1:209925295 C/T cg23920097 chr1:209922102 NA -0.39 -5.5 -0.32 9.14e-8 Red blood cell count; CESC cis rs7937682 0.575 rs7127010 chr11:111770782 C/T cg22437258 chr11:111473054 SIK2 -0.48 -5.3 -0.31 2.44e-7 Primary sclerosing cholangitis; CESC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg11494091 chr17:61959527 GH2 0.73 12.56 0.61 1.02e-28 Prudent dietary pattern; CESC cis rs2070433 0.800 rs11702190 chr21:47877367 C/T cg12379764 chr21:47803548 PCNT 0.66 7.47 0.42 1.13e-12 Lymphocyte counts; CESC cis rs11098499 0.954 rs12502423 chr4:120424172 A/C cg24375607 chr4:120327624 NA 0.5 6.17 0.35 2.61e-9 Corneal astigmatism; CESC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg25072359 chr17:41440525 NA 0.49 6.41 0.37 6.64e-10 Menopause (age at onset); CESC cis rs367943 1.000 rs348931 chr5:112812864 G/C cg12552261 chr5:112820674 MCC -0.62 -7.73 -0.43 2.27e-13 Type 2 diabetes; CESC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.37 -0.31 1.71e-7 Total body bone mineral density; CESC cis rs6429082 0.782 rs704705 chr1:235612320 C/T cg26050004 chr1:235667680 B3GALNT2 -0.61 -7.54 -0.42 7.34e-13 Adiposity; CESC cis rs9400271 0.632 rs949882 chr6:109586062 A/G cg01475377 chr6:109611718 NA 0.44 7.0 0.4 2.06e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs4853012 0.941 rs7571083 chr2:74342260 C/G cg01017244 chr2:74357527 NA 0.54 7.13 0.4 9.44e-12 Gestational age at birth (maternal effect); CESC cis rs13067593 1.000 rs11715620 chr3:188563772 T/G cg17809494 chr3:188572244 LPP 0.35 5.13 0.3 5.74e-7 Immune reponse to smallpox (secreted IFN-alpha); CESC cis rs2243480 1.000 rs7456042 chr7:65299778 T/C cg25894440 chr7:65020034 NA -0.61 -5.43 -0.32 1.25e-7 Diabetic kidney disease; CESC cis rs13191362 1.000 rs34619021 chr6:163029767 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.86 9.12 0.49 1.91e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs854765 0.583 rs12452219 chr17:17829423 C/T cg16928487 chr17:17741425 SREBF1 -0.59 -10.25 -0.53 5.56e-21 Total body bone mineral density; CESC cis rs4132509 1.000 rs2125230 chr1:243885848 A/G cg21452805 chr1:244014465 NA -0.45 -5.58 -0.32 5.92e-8 RR interval (heart rate); CESC cis rs9550616 0.801 rs9579787 chr13:20726921 G/T cg27436003 chr13:20734544 GJA3 0.37 5.31 0.31 2.31e-7 Facial emotion recognition (happy faces); CESC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg01448562 chr3:133502909 NA -0.42 -5.84 -0.34 1.55e-8 Iron status biomarkers; CESC cis rs735396 0.770 rs1169315 chr12:121443753 T/G cg02403541 chr12:121454288 C12orf43 0.75 10.48 0.54 1e-21 N-glycan levels; CESC cis rs7395581 0.918 rs11039166 chr11:47316691 A/C cg25783544 chr11:47291846 MADD 0.61 8.01 0.44 3.65e-14 HDL cholesterol; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11192808 chr8:101170185 SPAG1 -0.46 -6.01 -0.35 6.27e-9 Ulcerative colitis; CESC cis rs3796352 1.000 rs750474 chr3:53085280 A/C cg12962167 chr3:53033115 SFMBT1 0.55 5.56 0.32 6.66e-8 Immune reponse to smallpox (secreted IL-2); CESC trans rs3780486 0.846 rs913214 chr9:33135085 G/A cg20290983 chr6:43655470 MRPS18A 0.98 18.11 0.74 2.86e-48 IgG glycosylation; CESC cis rs765787 0.530 rs28526629 chr15:45540462 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -6.81 -0.39 6.42e-11 Uric acid levels; CESC cis rs4588572 0.643 rs13359053 chr5:77690224 T/C cg11547950 chr5:77652471 NA 0.45 5.71 0.33 3.06e-8 Triglycerides; CESC cis rs6121246 0.633 rs6060986 chr20:30426297 G/A cg13852791 chr20:30311386 BCL2L1 0.84 10.62 0.55 3.45e-22 Mean corpuscular hemoglobin; CESC cis rs7666738 0.719 rs4699323 chr4:98967484 G/A cg17366294 chr4:99064904 C4orf37 0.55 6.45 0.37 5.2400000000000005e-10 Colonoscopy-negative controls vs population controls; CESC trans rs11088226 0.681 rs2833906 chr21:33945521 G/T cg09050820 chr6:167586206 TCP10L2 0.91 9.31 0.5 5.03e-18 Gastritis; CESC cis rs76878669 0.538 rs4930360 chr11:66143247 T/A cg18002602 chr11:66138449 SLC29A2 0.4 6.62 0.38 1.96e-10 Educational attainment (years of education); CESC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg05890377 chr2:74357713 NA 0.76 10.34 0.54 2.76e-21 Gestational age at birth (maternal effect); CESC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg11890956 chr21:40555474 PSMG1 -0.6 -8.39 -0.46 2.99e-15 Menarche (age at onset); CESC cis rs7208859 0.623 rs73269923 chr17:29102571 C/T cg14008862 chr17:28927542 LRRC37B2 0.68 5.3 0.31 2.47e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg01246405 chr11:3876562 STIM1 0.5 6.81 0.39 6.46e-11 Weight; CESC cis rs5747327 0.874 rs5747323 chr22:18163539 G/A cg19898043 chr22:18121309 BCL2L13 -0.41 -5.16 -0.3 4.83e-7 Myeloid white cell count;Granulocyte count; CESC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg08470875 chr2:26401718 FAM59B 0.59 6.16 0.35 2.71e-9 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14490761 chr5:137878937 ETF1 0.5 6.55 0.37 2.99e-10 Gut microbiota (bacterial taxa); CESC cis rs7605827 0.930 rs12692268 chr2:15595519 A/G cg19274914 chr2:15703543 NA 0.34 6.12 0.35 3.4e-9 Educational attainment (years of education); CESC cis rs559928 0.606 rs11605856 chr11:63925528 C/T cg18225595 chr11:63971243 STIP1 0.65 5.97 0.34 7.73e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC trans rs13063635 0.915 rs71325091 chr3:45932407 G/A cg10236987 chr1:228114221 WNT9A 0.64 6.58 0.37 2.56e-10 Eosinophil percentage of granulocytes; CESC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg24829409 chr8:58192753 C8orf71 -0.75 -9.89 -0.52 7.84e-20 Developmental language disorder (linguistic errors); CESC cis rs2439831 0.681 rs526450 chr15:43599325 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.87 12.86 0.62 1e-29 Lung cancer in ever smokers; CESC cis rs477692 0.673 rs10829600 chr10:131322051 G/C cg24747557 chr10:131355152 MGMT -0.38 -5.22 -0.31 3.69e-7 Response to temozolomide; CESC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 11.0 0.56 1.98e-23 Platelet count; CESC cis rs9300255 0.739 rs11057210 chr12:123733799 A/G cg05973401 chr12:123451056 ABCB9 0.49 5.51 0.32 8.7e-8 Neutrophil percentage of white cells; CESC cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg21918786 chr6:109611834 NA -0.36 -5.22 -0.31 3.63e-7 Reticulocyte fraction of red cells; CESC cis rs11166927 1.000 rs13256625 chr8:140805003 G/T cg16909799 chr8:140841666 TRAPPC9 0.62 9.07 0.49 2.83e-17 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg13206674 chr6:150067644 NUP43 -0.45 -6.39 -0.37 7.31e-10 Lung cancer; CESC cis rs1448094 0.549 rs4919770 chr12:86238050 G/T cg02569458 chr12:86230093 RASSF9 0.52 7.5 0.42 9.37e-13 Major depressive disorder; CESC cis rs2439831 0.681 rs528517 chr15:43612925 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.56 0.61 1.09e-28 Lung cancer in ever smokers; CESC cis rs12291225 0.679 rs34238445 chr11:14315915 C/T cg19336497 chr11:14380999 RRAS2 -0.37 -5.27 -0.31 2.89e-7 Sense of smell; CESC cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg26874164 chr19:58962979 ZNF324B 0.54 7.41 0.41 1.73e-12 Uric acid clearance; CESC cis rs7267979 0.903 rs1118963 chr20:25247449 G/A cg08601574 chr20:25228251 PYGB 0.42 5.9 0.34 1.12e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9815354 0.812 rs17215988 chr3:41851320 A/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg04267008 chr7:1944627 MAD1L1 -0.57 -6.83 -0.39 5.77e-11 Bipolar disorder and schizophrenia; CESC cis rs9287719 0.745 rs4997809 chr2:10755542 G/A cg00105475 chr2:10696890 NA 0.37 5.2 0.3 3.96e-7 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04094107 chr15:73976560 CD276 -0.53 -7.2 -0.4 6.21e-12 Fibrinogen levels; CESC cis rs2243480 1.000 rs34974928 chr7:65364006 T/C cg18252515 chr7:66147081 NA -1.01 -9.32 -0.5 4.6e-18 Diabetic kidney disease; CESC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg18337363 chr3:52569053 NT5DC2 0.28 5.13 0.3 5.59e-7 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16480132 chr7:149571111 LOC401431;ATP6V0E2 -0.44 -6.74 -0.38 1.01e-10 Gambling; CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg18538332 chr22:24372958 LOC391322 0.68 9.68 0.51 3.49e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs79349575 0.783 rs62075852 chr17:47017176 T/C cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs17253792 0.822 rs10137340 chr14:56050989 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.81 6.52 0.37 3.55e-10 Putamen volume; CESC cis rs2816062 0.813 rs742485 chr1:18900943 A/T cg18795169 chr1:18902165 NA -0.93 -18.14 -0.74 2.22e-48 Urate levels in lean individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16419620 chr12:48214187 HDAC7 -0.58 -6.86 -0.39 4.75e-11 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs4660331 chr1:46458783 A/C cg03146154 chr1:46216737 IPP 0.74 10.23 0.53 6.52e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11696501 0.688 rs6104293 chr20:44326298 T/C cg11783356 chr20:44313418 WFDC10B -0.31 -5.08 -0.3 7.02e-7 Brain structure; CESC cis rs3096299 0.719 rs2965818 chr16:89510494 A/G cg02187348 chr16:89574699 SPG7 0.62 8.58 0.47 8.33e-16 Multiple myeloma (IgH translocation); CESC cis rs763121 0.853 rs6001188 chr22:39062194 T/C cg06544989 chr22:39130855 UNC84B 0.51 8.91 0.48 8.21e-17 Menopause (age at onset); CESC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg10819733 chr22:24237672 NA -0.47 -6.69 -0.38 1.33e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg08822215 chr16:89438651 ANKRD11 -0.43 -6.59 -0.38 2.38e-10 Multiple myeloma (IgH translocation); CESC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.56 -0.32 6.48e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg18350739 chr11:68623251 NA -0.43 -6.72 -0.38 1.09e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs708547 0.647 rs2293175 chr4:57861358 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.59 8.71 0.47 3.29e-16 Response to bleomycin (chromatid breaks); CESC trans rs11770686 0.967 rs4728289 chr7:75348505 C/T cg02552079 chr4:1220951 CTBP1 -0.39 -6.04 -0.35 5.29e-9 Essential tremor; CESC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg03647317 chr4:187891568 NA -0.44 -6.76 -0.38 8.81e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs12142240 0.698 rs41294478 chr1:46818442 G/A cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs9303401 0.646 rs7342863 chr17:57227010 G/A cg12560992 chr17:57184187 TRIM37 0.44 5.31 0.31 2.29e-7 Cognitive test performance; CESC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg04944784 chr2:26401820 FAM59B -0.91 -10.38 -0.54 2.12e-21 Gut microbiome composition (summer); CESC cis rs6942756 0.806 rs6467240 chr7:128984018 T/C cg02491457 chr7:128862824 NA -0.61 -8.63 -0.47 5.7e-16 White matter hyperintensity burden; CESC cis rs11677416 0.885 rs4849119 chr2:113523463 G/C cg27083787 chr2:113543245 IL1A 0.58 7.33 0.41 2.81e-12 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg22764044 chr5:178986830 RUFY1 0.45 6.78 0.38 7.76e-11 Lung cancer; CESC cis rs703842 1.000 rs11172351 chr12:58213485 C/T cg18357645 chr12:58087776 OS9 -0.41 -5.65 -0.33 4.08e-8 Multiple sclerosis; CESC cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg05535760 chr7:792225 HEATR2 -0.78 -8.24 -0.45 8.16e-15 Cerebrospinal P-tau181p levels; CESC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.7 -0.33 3.23e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg07636037 chr3:49044803 WDR6 1.06 19.29 0.76 2.09e-52 Parkinson's disease; CESC cis rs3015497 0.967 rs8018308 chr14:51122633 T/C cg26011998 chr14:51135199 SAV1 -0.44 -5.53 -0.32 7.8e-8 Mean platelet volume; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg27524515 chr8:38239417 WHSC1L1 0.48 6.37 0.36 8.16e-10 Height; CESC cis rs826838 0.935 rs1486357 chr12:39073675 A/G cg26384229 chr12:38710491 ALG10B 0.8 13.4 0.64 1.26e-31 Heart rate; CESC cis rs2288073 1.000 rs6708328 chr2:24412413 A/G cg06627628 chr2:24431161 ITSN2 -0.79 -9.79 -0.52 1.6e-19 Venous thromboembolism (SNP x SNP interaction); CESC cis rs916888 0.610 rs199529 chr17:44837217 A/C cg15921436 chr17:44337874 NA 0.61 7.37 0.41 2.2e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2204008 0.837 rs7315255 chr12:37949279 G/A cg26384229 chr12:38710491 ALG10B 0.75 11.2 0.57 4.3e-24 Bladder cancer; CESC cis rs17376456 0.877 rs17315943 chr5:93442830 T/C cg25358565 chr5:93447407 FAM172A 1.15 11.35 0.57 1.34e-24 Diabetic retinopathy; CESC trans rs11039798 0.688 rs10839007 chr11:48703442 A/C cg15704280 chr7:45808275 SEPT13 0.69 6.29 0.36 1.33e-9 Axial length; CESC cis rs2404602 0.647 rs907594 chr15:77197745 C/A cg23625390 chr15:77176239 SCAPER -0.46 -6.45 -0.37 5.34e-10 Blood metabolite levels; CESC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg01988459 chr11:68622903 NA -0.39 -5.21 -0.3 3.76e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg18769074 chr3:133464867 TF 0.29 5.42 0.32 1.36e-7 Iron status biomarkers (transferrin levels); CESC cis rs9287719 0.781 rs6714795 chr2:10759134 C/T cg00105475 chr2:10696890 NA 0.35 5.07 0.3 7.65e-7 Prostate cancer; CESC cis rs13242816 1.000 rs67652573 chr7:116109958 T/C cg04696780 chr7:116139425 CAV2 -0.63 -5.71 -0.33 2.98e-8 P wave duration; CESC cis rs9911578 0.967 rs6503893 chr17:57149695 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.16 0.3 4.91e-7 Intelligence (multi-trait analysis); CESC cis rs6732160 0.845 rs6546809 chr2:73389681 A/C cg01422370 chr2:73384389 NA 0.45 7.77 0.43 1.73e-13 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg22143856 chr6:28129313 ZNF389 0.52 6.77 0.38 8.31e-11 Depression; CESC cis rs858239 0.600 rs61292332 chr7:23131862 C/T cg23682824 chr7:23144976 KLHL7 0.54 7.34 0.41 2.63e-12 Cerebrospinal fluid biomarker levels; CESC cis rs4660306 1.000 rs10157597 chr1:45990278 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.92e-13 Homocysteine levels; CESC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg07701084 chr6:150067640 NUP43 0.43 5.71 0.33 3.1e-8 Lung cancer; CESC cis rs9583531 0.600 rs6492306 chr13:111361693 G/A cg15841412 chr13:111365552 ING1 0.47 6.31 0.36 1.17e-9 Coronary artery disease; CESC trans rs1814175 0.645 rs10839448 chr11:49938930 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -6.25 -0.36 1.68e-9 Height; CESC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.13 0.81 3.58e-62 Prudent dietary pattern; CESC cis rs6582630 0.559 rs12318620 chr12:38522340 T/C cg26384229 chr12:38710491 ALG10B -0.46 -6.23 -0.36 1.83e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs919433 0.889 rs12472355 chr2:198205840 C/A cg03934865 chr2:198174659 NA -0.45 -6.53 -0.37 3.26e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2243480 1.000 rs781142 chr7:65438778 C/T cg12463550 chr7:65579703 CRCP 0.67 5.54 0.32 7.11e-8 Diabetic kidney disease; CESC trans rs2950393 0.509 rs10459247 chr12:57171516 T/C cg26462586 chr2:11164677 NA 0.39 6.15 0.35 2.82e-9 Platelet distribution width; CESC trans rs12107539 1.000 rs4680356 chr3:151051100 A/G cg05862518 chr17:40277425 RAB5C -0.47 -6.19 -0.36 2.34e-9 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC cis rs748404 0.660 rs518288 chr15:43763999 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.33 0.46 4.53e-15 Lung cancer; CESC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg26338869 chr17:61819248 STRADA 0.67 8.82 0.48 1.6e-16 Prudent dietary pattern; CESC cis rs453301 0.624 rs330056 chr8:9089695 A/T cg17143192 chr8:8559678 CLDN23 -0.45 -5.41 -0.32 1.42e-7 Joint mobility (Beighton score); CESC cis rs240764 0.764 rs11155472 chr6:100921549 A/T cg21058520 chr6:100914733 NA 0.36 5.64 0.33 4.44e-8 Neuroticism; CESC cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg06212747 chr3:49208901 KLHDC8B 0.65 8.81 0.48 1.68e-16 Parkinson's disease; CESC cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg13880726 chr7:1868755 MAD1L1 0.53 7.14 0.4 8.82e-12 Bipolar disorder and schizophrenia; CESC cis rs400736 0.655 rs11121086 chr1:8151224 C/T cg25007680 chr1:8021821 PARK7 -0.6 -8.29 -0.45 5.83e-15 Response to antidepressants and depression; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16389252 chr1:894601 KLHL17;NOC2L -0.51 -6.51 -0.37 3.67e-10 Asthma; CESC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg22433210 chr17:43662623 NA 1.0 11.15 0.57 6.21e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9788682 0.668 rs2036529 chr15:78726272 A/T cg24631222 chr15:78858424 CHRNA5 -0.62 -7.34 -0.41 2.67e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7927592 0.913 rs6591346 chr11:68384618 T/A cg01657329 chr11:68192670 LRP5 -0.39 -5.04 -0.3 8.72e-7 Total body bone mineral density; CESC cis rs12477438 0.798 rs6759354 chr2:99632195 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.95 -0.56 2.84e-23 Chronic sinus infection; CESC cis rs72781680 0.898 rs72786277 chr2:24062818 T/G cg08917208 chr2:24149416 ATAD2B 0.93 8.48 0.46 1.57e-15 Lymphocyte counts; CESC cis rs709400 0.628 rs11621510 chr14:103869620 T/C cg12935359 chr14:103987150 CKB -0.5 -7.2 -0.4 6.09e-12 Body mass index; CESC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg08027265 chr7:2291960 NA -0.44 -6.84 -0.39 5.51e-11 Bipolar disorder and schizophrenia; CESC cis rs11098499 0.657 rs10434028 chr4:120294464 T/G cg09307838 chr4:120376055 NA 0.85 11.38 0.57 1.1e-24 Corneal astigmatism; CESC cis rs568617 1.000 rs656980 chr11:65656282 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.69 7.43 0.42 1.47e-12 Crohn's disease; CESC cis rs11971779 1.000 rs11971779 chr7:139040258 A/G cg07862535 chr7:139043722 LUC7L2 -0.54 -5.51 -0.32 8.7e-8 Diisocyanate-induced asthma; CESC cis rs796364 0.951 rs35618222 chr2:201065777 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.64 5.89 0.34 1.16e-8 Schizophrenia; CESC cis rs727505 0.954 rs989177 chr7:124412886 A/G cg23710748 chr7:124431027 NA -0.46 -7.26 -0.41 4.23e-12 Lewy body disease; CESC cis rs3820928 0.874 rs13393894 chr2:227880543 A/G cg11843606 chr2:227700838 RHBDD1 -0.46 -6.09 -0.35 3.87e-9 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14276772 chr2:10588646 ODC1 0.55 6.31 0.36 1.17e-9 Gut microbiome composition (summer); CESC cis rs4654899 0.865 rs6665549 chr1:21475884 G/C cg05370193 chr1:21551575 ECE1 0.46 7.08 0.4 1.28e-11 Superior frontal gyrus grey matter volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19942813 chr3:187463496 BCL6 -0.48 -6.17 -0.35 2.58e-9 Ulcerative colitis; CESC cis rs10242455 0.702 rs78218664 chr7:99154381 C/A cg18809830 chr7:99032528 PTCD1 -0.64 -5.03 -0.3 9.06e-7 Blood metabolite levels; CESC cis rs2657888 0.931 rs7301093 chr12:56933244 G/T cg23002907 chr12:56915593 RBMS2 0.4 5.22 0.31 3.53e-7 Adiponectin levels; CESC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7246657 0.941 rs7259618 chr19:37750719 G/A cg23950597 chr19:37808831 NA -0.63 -6.49 -0.37 4.22e-10 Coronary artery calcification; CESC cis rs6688613 0.694 rs11576455 chr1:166811970 G/A ch.1.3259774R chr1:166827647 TADA1 0.6 6.02 0.35 5.83e-9 Refractive astigmatism; CESC cis rs1949733 0.554 rs4259044 chr4:8536188 A/G cg11789530 chr4:8429930 ACOX3 -0.57 -7.24 -0.41 4.9e-12 Response to antineoplastic agents; CESC cis rs7577696 0.568 rs410469 chr2:32476992 G/T cg02381751 chr2:32503542 YIPF4 -0.43 -5.16 -0.3 4.93e-7 Inflammatory biomarkers; CESC cis rs910316 1.000 rs12589376 chr14:75561152 C/T cg11812906 chr14:75593930 NEK9 0.89 15.08 0.68 1.6e-37 Height; CESC cis rs4423214 1.000 rs12792306 chr11:71166992 T/C cg05163923 chr11:71159392 DHCR7 0.84 11.53 0.58 3.3e-25 Vitamin D levels; CESC cis rs6088580 0.524 rs7274854 chr20:33228672 A/C cg24642439 chr20:33292090 TP53INP2 0.42 5.03 0.3 8.97e-7 Glomerular filtration rate (creatinine); CESC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs72945132 0.882 rs11235755 chr11:70136323 A/G cg00319359 chr11:70116639 PPFIA1 0.78 7.67 0.43 3.32e-13 Coronary artery disease; CESC cis rs6087990 0.899 rs998382 chr20:31384136 C/T cg13636640 chr20:31349939 DNMT3B -0.84 -14.74 -0.67 2.64e-36 Ulcerative colitis; CESC cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg18876405 chr7:65276391 NA 0.48 5.27 0.31 2.88e-7 Aortic root size; CESC cis rs7662987 0.517 rs2602877 chr4:100039847 T/A cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC cis rs4812048 0.649 rs6070702 chr20:57621562 G/C cg14073986 chr20:57617431 SLMO2 0.83 7.12 0.4 9.9e-12 Mean platelet volume; CESC cis rs17376456 0.542 rs1982439 chr5:93160560 C/G cg21475434 chr5:93447410 FAM172A -0.51 -5.16 -0.3 4.73e-7 Diabetic retinopathy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26419957 chr12:122252518 SETD1B 0.55 7.36 0.41 2.35e-12 Fibrinogen levels; CESC cis rs3733585 0.673 rs4455410 chr4:9953297 C/T cg00071950 chr4:10020882 SLC2A9 0.69 10.99 0.56 2.1e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6460942 0.915 rs62447641 chr7:12488764 G/A cg02935154 chr7:12443704 VWDE -0.56 -5.84 -0.34 1.5e-8 Coronary artery disease; CESC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg13147721 chr7:65941812 NA 0.37 5.04 0.3 8.53e-7 Aortic root size; CESC cis rs793571 0.774 rs4775096 chr15:59140329 A/G cg05156742 chr15:59063176 FAM63B 0.5 6.1 0.35 3.79e-9 Schizophrenia; CESC cis rs7264396 0.570 rs1970576 chr20:34336720 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.46 0.42 1.24e-12 Total cholesterol levels; CESC cis rs9359856 0.564 rs17292425 chr6:90372128 A/G cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.7 -0.33 3.12e-8 Bipolar disorder; CESC cis rs10779751 1.000 rs11121706 chr1:11302065 C/T cg08854313 chr1:11322531 MTOR 0.79 11.12 0.56 7.87e-24 Body mass index; CESC cis rs7520050 1.000 rs785473 chr1:46516863 T/C cg03146154 chr1:46216737 IPP -0.44 -5.72 -0.33 2.88e-8 Red blood cell count;Reticulocyte count; CESC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg23281280 chr6:28129359 ZNF389 0.48 5.84 0.34 1.52e-8 Parkinson's disease; CESC cis rs2637266 0.783 rs7898786 chr10:78481338 T/C cg18941641 chr10:78392320 NA 0.44 8.37 0.46 3.27e-15 Pulmonary function; CESC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg11764359 chr7:65958608 NA -0.73 -9.77 -0.51 1.93e-19 Aortic root size; CESC trans rs561341 1.000 rs7210970 chr17:30262169 G/A cg20587970 chr11:113659929 NA -0.8 -9.97 -0.52 4.47e-20 Hip circumference adjusted for BMI; CESC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg23048001 chr7:2026167 MAD1L1 0.4 5.14 0.3 5.34e-7 Bipolar disorder and schizophrenia; CESC trans rs10411161 0.702 rs10420224 chr19:52398955 A/G cg22319618 chr22:45562946 NUP50 -0.75 -7.3 -0.41 3.33e-12 Breast cancer; CESC cis rs58235267 0.656 rs12713469 chr2:63059927 C/T cg17519650 chr2:63277830 OTX1 -0.68 -9.84 -0.52 1.1e-19 Prostate-specific antigen levels (conditioned on lead SNPs); CESC cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg16144293 chr14:75469539 EIF2B2 0.39 5.13 0.3 5.74e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23521069 chr14:39583513 SIP1 -0.59 -7.06 -0.4 1.44e-11 Gut microbiome composition (summer); CESC cis rs2933343 0.649 rs789214 chr3:128594995 A/G cg24203234 chr3:128598194 ACAD9 0.44 5.9 0.34 1.09e-8 IgG glycosylation; CESC cis rs4132509 1.000 rs7534117 chr1:243964902 A/C cg21452805 chr1:244014465 NA -0.4 -5.13 -0.3 5.53e-7 RR interval (heart rate); CESC cis rs2637266 1.000 rs10824425 chr10:78340310 C/G cg18941641 chr10:78392320 NA 0.41 7.61 0.42 4.86e-13 Pulmonary function; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04391736 chr16:69373674 COG8;NIP7 0.47 6.77 0.38 8.38e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg22467129 chr15:76604101 ETFA -0.39 -5.89 -0.34 1.15e-8 Blood metabolite levels; CESC trans rs7944735 0.507 rs10838802 chr11:48102478 A/G cg15704280 chr7:45808275 SEPT13 0.62 7.86 0.43 9.49e-14 Intraocular pressure; CESC cis rs11190604 1.000 rs2495742 chr10:102331364 C/T cg07080220 chr10:102295463 HIF1AN 0.64 5.85 0.34 1.46e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs6964587 1.000 rs6964587 chr7:91630620 G/T cg17063962 chr7:91808500 NA 0.56 7.72 0.43 2.41e-13 Breast cancer; CESC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg22968622 chr17:43663579 NA -1.21 -16.16 -0.7 2.31e-41 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs324780 0.544 rs439870 chr12:83928582 A/G cg22140261 chr22:42466895 NAGA -0.48 -6.12 -0.35 3.34e-9 Vertical cup-disc ratio; CESC cis rs1538970 1.000 rs9326141 chr1:45828943 A/G cg06784218 chr1:46089804 CCDC17 -0.31 -5.08 -0.3 7.04e-7 Platelet count; CESC cis rs4722166 0.695 rs7793125 chr7:22809160 A/G cg05472934 chr7:22766657 IL6 0.61 8.09 0.44 2.21e-14 Lung cancer; CESC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.43e-7 Life satisfaction; CESC cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg22467129 chr15:76604101 ETFA 0.38 5.94 0.34 8.99e-9 Blood metabolite levels; CESC cis rs853679 0.769 rs17720293 chr6:28214698 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.72 5.79 0.34 1.95e-8 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00134212 chr18:657361 C18orf56;TYMS -0.61 -7.07 -0.4 1.41e-11 Gut microbiome composition (summer); CESC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg17143192 chr8:8559678 CLDN23 0.72 8.54 0.46 1.07e-15 Obesity-related traits; CESC cis rs6088580 0.634 rs1890000 chr20:32968312 G/T cg08999081 chr20:33150536 PIGU -0.65 -11.36 -0.57 1.22e-24 Glomerular filtration rate (creatinine); CESC cis rs7129220 0.588 rs61878634 chr11:10140114 A/T cg01453529 chr11:10209919 SBF2 -0.48 -5.63 -0.33 4.67e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs4740619 0.511 rs3008731 chr9:16003441 G/A cg14451791 chr9:16040625 NA -0.37 -5.81 -0.34 1.8e-8 Body mass index; CESC cis rs4604732 0.642 rs7549312 chr1:247640078 C/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.38 0.31 1.63e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6088590 1.000 rs2295353 chr20:33356511 C/T cg08999081 chr20:33150536 PIGU 0.6 9.0 0.48 4.6e-17 Coronary artery disease; CESC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg11965913 chr1:205819406 PM20D1 0.83 12.87 0.62 9.23e-30 Menarche (age at onset); CESC cis rs9308433 0.529 rs10465696 chr1:214499883 G/A cg06198575 chr1:214491504 SMYD2 0.5 6.0 0.35 6.37e-9 IgG glycosylation; CESC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs10832963 1.000 rs2084220 chr11:18656932 C/T cg09201001 chr11:18656081 SPTY2D1 0.82 12.44 0.61 2.79e-28 Breast cancer; CESC cis rs12995491 0.933 rs34366691 chr2:88537451 G/A cg18490616 chr2:88469792 THNSL2 -0.54 -8.06 -0.44 2.59e-14 Response to metformin (IC50); CESC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg08888203 chr3:10149979 C3orf24 0.48 6.17 0.35 2.6e-9 Alzheimer's disease; CESC cis rs6754311 0.597 rs6760329 chr2:136544752 A/G cg07169764 chr2:136633963 MCM6 -0.73 -9.46 -0.5 1.76e-18 Mosquito bite size; CESC cis rs4835473 0.750 rs56372690 chr4:144656969 T/A cg25736465 chr4:144833511 NA -0.33 -5.25 -0.31 3.06e-7 Immature fraction of reticulocytes; CESC cis rs11098499 0.954 rs6847248 chr4:120225955 A/G cg24375607 chr4:120327624 NA 0.47 5.46 0.32 1.07e-7 Corneal astigmatism; CESC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.61 0.33 5.01e-8 Major depressive disorder; CESC cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.33 0.41 2.86e-12 Tonsillectomy; CESC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg07343612 chr16:622815 PIGQ -0.57 -8.37 -0.46 3.44e-15 Height; CESC cis rs938554 0.501 rs7671266 chr4:10056376 C/T cg11266682 chr4:10021025 SLC2A9 -0.54 -7.6 -0.42 5.03e-13 Blood metabolite levels; CESC cis rs1784581 0.500 rs9355379 chr6:162421466 C/T cg17173639 chr6:162384350 PARK2 0.51 5.66 0.33 3.95e-8 Itch intensity from mosquito bite; CESC cis rs7084402 0.967 rs1427198 chr10:60274970 T/G cg07615347 chr10:60278583 BICC1 -0.57 -8.96 -0.48 6.01e-17 Refractive error; CESC trans rs2727020 0.729 rs2866328 chr11:49282421 A/G cg03929089 chr4:120376271 NA 0.79 11.91 0.59 1.7e-26 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13984512 chr1:145438431 TXNIP 0.58 7.15 0.4 8.65e-12 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs709400 0.628 rs7154246 chr14:103876794 G/A cg12935359 chr14:103987150 CKB 0.48 7.16 0.4 8e-12 Body mass index; CESC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg11890956 chr21:40555474 PSMG1 -0.97 -15.84 -0.7 3.36e-40 Cognitive function; CESC cis rs1878931 0.535 rs10852706 chr16:3412582 G/C cg02880119 chr16:3481970 NA -0.41 -5.33 -0.31 2.06e-7 Body mass index (adult); CESC cis rs4925386 0.559 rs2427291 chr20:60921324 G/A cg12382846 chr20:60892121 LAMA5 0.45 5.77 0.33 2.16e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC trans rs11227306 0.934 rs7102454 chr11:65594820 C/T cg17712092 chr4:129076599 LARP1B -0.63 -7.06 -0.4 1.47e-11 DNA methylation (variation); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg16319310 chr10:52390957 NA -0.51 -7.07 -0.4 1.38e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs637571 0.522 rs7105628 chr11:65763067 C/T cg17712092 chr4:129076599 LARP1B 0.75 10.38 0.54 2.16e-21 Eosinophil percentage of white cells; CESC cis rs12931792 0.712 rs2887799 chr16:30163833 G/A cg17640201 chr16:30407289 ZNF48 0.6 8.0 0.44 3.8e-14 Tonsillectomy; CESC cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg18512352 chr11:47633146 NA -0.52 -7.38 -0.41 1.99e-12 Subjective well-being; CESC cis rs2014572 0.870 rs10426580 chr19:57756221 G/A cg12963866 chr19:57752005 ZNF805 -0.49 -6.49 -0.37 4.09e-10 Hyperactive-impulsive symptoms; CESC cis rs7103648 0.695 rs11039290 chr11:47572279 G/A cg10504702 chr11:47789108 FNBP4 0.43 5.23 0.31 3.52e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs709400 0.628 rs10141120 chr14:103923008 T/C cg12935359 chr14:103987150 CKB -0.51 -7.46 -0.42 1.24e-12 Body mass index; CESC cis rs796364 1.000 rs796364 chr2:200716119 C/A cg23649088 chr2:200775458 C2orf69 0.55 5.22 0.31 3.54e-7 Schizophrenia; CESC cis rs10461617 0.512 rs7715746 chr5:56048837 C/T cg24531977 chr5:56204891 C5orf35 -0.64 -8.18 -0.45 1.2e-14 Type 2 diabetes; CESC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg11301795 chr4:187892539 NA -0.72 -11.06 -0.56 1.3e-23 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00871673 chr12:122516220 MLXIP 0.59 6.75 0.38 9.07e-11 Gut microbiome composition (summer); CESC cis rs6032067 0.925 rs13042522 chr20:43829290 G/A cg10761708 chr20:43804764 PI3 0.52 6.15 0.35 2.77e-9 Blood protein levels; CESC cis rs10191773 0.535 rs11123133 chr2:112965023 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.68 -6.92 -0.39 3.36e-11 Yeast infection; CESC cis rs4629180 0.651 rs9653468 chr2:102108403 A/G cg04415270 chr2:102091202 RFX8 -0.3 -5.19 -0.3 4.25e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs11203032 1.000 rs61853072 chr10:90961500 A/T cg16672925 chr10:90967113 CH25H 0.75 7.18 0.4 7.13e-12 Heart failure; CESC cis rs854765 0.520 rs9899355 chr17:17898243 C/T cg16928487 chr17:17741425 SREBF1 -0.47 -7.6 -0.42 5.21e-13 Total body bone mineral density; CESC cis rs9322193 0.607 rs9371228 chr6:150243113 G/A cg01145232 chr6:150245071 RAET1G -0.56 -7.2 -0.4 6.1e-12 Lung cancer; CESC cis rs829661 0.947 rs829665 chr2:30724701 T/A cg03795903 chr2:30669940 LCLAT1 0.65 5.63 0.33 4.6e-8 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC trans rs17143387 0.614 rs11597013 chr10:8345388 C/G cg21762820 chr1:166135233 FAM78B 0.51 6.1 0.35 3.67e-9 Scalp hair shape; CESC cis rs611744 0.647 rs585077 chr8:109245497 C/T cg21045802 chr8:109455806 TTC35 0.45 5.53 0.32 7.53e-8 Dupuytren's disease; CESC cis rs2243480 0.522 rs778717 chr7:65848151 G/C cg13147721 chr7:65941812 NA -0.86 -6.39 -0.37 7.4e-10 Diabetic kidney disease; CESC cis rs6582630 0.555 rs11181657 chr12:38381858 T/C cg26384229 chr12:38710491 ALG10B -0.68 -10.43 -0.54 1.4e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs3820068 0.608 rs7514858 chr1:16035246 G/A cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.35 4.28e-9 Systolic blood pressure; CESC cis rs733592 0.524 rs10875741 chr12:48492922 A/C cg04545296 chr12:48745243 ZNF641 -0.3 -5.54 -0.32 7.37e-8 Plateletcrit; CESC cis rs1348850 0.914 rs2364854 chr2:178378452 T/A cg23306229 chr2:178417860 TTC30B 0.62 7.97 0.44 4.84e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7249142 0.562 rs1050544 chr19:19287901 A/G cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.28 5.21 0.3 3.8e-7 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27345282 chr3:196295526 WDR53;FBXO45 0.55 6.14 0.35 3.02e-9 Gut microbiome composition (summer); CESC cis rs11997175 0.603 rs7386384 chr8:33782471 C/T ch.8.33884649F chr8:33765107 NA 0.49 5.88 0.34 1.23e-8 Body mass index; CESC cis rs2294693 0.945 rs9349175 chr6:40982401 T/C cg14769373 chr6:40998127 UNC5CL -0.5 -6.43 -0.37 5.95e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg17971929 chr21:40555470 PSMG1 -0.62 -7.49 -0.42 1e-12 Menarche (age at onset); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg15882797 chr19:7615191 PNPLA6 0.52 6.96 0.39 2.72e-11 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11674231 chr7:5821297 RNF216 0.52 6.39 0.37 7.45e-10 Gut microbiome composition (summer); CESC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.23 0.41 5.08e-12 Bipolar disorder; CESC cis rs1062177 0.774 rs2964574 chr5:151155711 G/A cg00977110 chr5:151150581 G3BP1 0.62 6.76 0.38 8.65e-11 Preschool internalizing problems; CESC cis rs748404 0.631 rs2412781 chr15:43667900 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.54 -8.45 -0.46 1.99e-15 Lung cancer; CESC cis rs12477438 0.765 rs6750876 chr2:99679673 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs1953600 0.870 rs2573370 chr10:81951366 C/T cg00277334 chr10:82204260 NA 0.45 6.28 0.36 1.4e-9 Sarcoidosis; CESC cis rs6433857 0.657 rs6756509 chr2:181500273 T/C cg23363182 chr2:181467187 NA -0.45 -6.8 -0.39 6.88e-11 Body mass index; CESC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.75 -9.82 -0.52 1.31e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7193541 0.510 rs79473128 chr16:74589192 G/A cg01733217 chr16:74700730 RFWD3 0.84 11.38 0.57 1.07e-24 Multiple myeloma; CESC cis rs67311347 1.000 rs7631893 chr3:40440869 C/T cg01475735 chr3:40494733 NA -0.42 -5.54 -0.32 7.28e-8 Renal cell carcinoma; CESC cis rs10899021 0.512 rs2186955 chr11:74375475 C/T cg25880958 chr11:74394337 NA 0.53 6.81 0.39 6.48e-11 Response to metformin (IC50); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11176342 chr11:18344099 HPS5;GTF2H1 0.57 6.02 0.35 5.73e-9 Gut microbiome composition (summer); CESC cis rs67460515 0.665 rs28384382 chr3:160939141 C/T cg03342759 chr3:160939853 NMD3 -0.57 -7.74 -0.43 2.11e-13 Parkinson's disease; CESC cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg20701182 chr2:24300061 SF3B14 0.91 10.23 0.53 6.45e-21 Lymphocyte counts; CESC cis rs2439831 0.867 rs3213990 chr15:43670226 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.98 0.56 2.32e-23 Lung cancer in ever smokers; CESC cis rs9902453 0.934 rs34433787 chr17:28496780 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.84 0.43 1.08e-13 Coffee consumption (cups per day); CESC cis rs12142240 0.698 rs9661240 chr1:46827050 G/A cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs425277 0.606 rs3128295 chr1:2068480 C/T cg16545954 chr1:2118288 C1orf86 -0.35 -6.45 -0.37 5.23e-10 Height; CESC cis rs929354 0.772 rs6969244 chr7:157004012 A/G cg05182265 chr7:156933206 UBE3C -0.51 -7.47 -0.42 1.16e-12 Body mass index; CESC cis rs9902453 0.904 rs6505148 chr17:28289818 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 9.34 0.5 4.05e-18 Coffee consumption (cups per day); CESC cis rs2050392 0.965 rs2265368 chr10:30690289 G/C cg18806716 chr10:30721971 MAP3K8 -0.39 -5.6 -0.33 5.35e-8 Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20796294 chr1:220219430 EPRS 0.55 6.14 0.35 2.98e-9 Gut microbiome composition (summer); CESC cis rs11690935 0.959 rs10174525 chr2:172635697 T/C cg13550731 chr2:172543902 DYNC1I2 -1.02 -16.98 -0.72 2.91e-44 Schizophrenia; CESC cis rs7116495 1.000 rs679926 chr11:71769936 A/G cg10381502 chr11:71823885 C11orf51 0.68 5.81 0.34 1.81e-8 Severe influenza A (H1N1) infection; CESC cis rs78456975 0.527 rs4073862 chr2:1563433 A/G cg12573674 chr2:1569213 NA -0.43 -5.11 -0.3 6.09e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg11965913 chr1:205819406 PM20D1 -0.47 -6.48 -0.37 4.5e-10 Menarche (age at onset); CESC cis rs8062405 0.755 rs56272201 chr16:28580685 A/G cg07382826 chr16:28625726 SULT1A1 0.39 6.29 0.36 1.34e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs977987 0.835 rs8057535 chr16:75347941 C/T cg03315344 chr16:75512273 CHST6 0.39 5.59 0.32 5.55e-8 Dupuytren's disease; CESC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg21854759 chr1:92012499 NA -0.44 -5.65 -0.33 4.18e-8 Breast cancer; CESC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg09323728 chr8:95962352 TP53INP1 -0.44 -10.1 -0.53 1.69e-20 Type 2 diabetes; CESC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg12963246 chr6:28129442 ZNF389 0.39 5.65 0.33 4.21e-8 Parkinson's disease; CESC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.45 0.58 6.38e-25 Alzheimer's disease; CESC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.62 5.28 0.31 2.69e-7 Depression; CESC cis rs1008375 0.932 rs4698628 chr4:17608620 A/G cg02297831 chr4:17616191 MED28 0.52 6.53 0.37 3.27e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22542420 chr17:43183176 NMT1 -0.55 -6.14 -0.35 2.94e-9 Gut microbiome composition (summer); CESC cis rs2191566 0.821 rs62119173 chr19:44518073 G/A cg20607764 chr19:44506953 ZNF230 -0.58 -7.58 -0.42 5.8e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs9584850 0.708 rs4411372 chr13:99130423 T/C cg20750642 chr13:99100586 FARP1 -0.37 -5.39 -0.31 1.53e-7 Neuroticism; CESC cis rs6545883 0.895 rs4430924 chr2:61703856 A/G cg15711740 chr2:61764176 XPO1 -0.4 -5.05 -0.3 8.35e-7 Tuberculosis; CESC cis rs116095464 0.558 rs6875291 chr5:264192 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.49 0.32 9.44e-8 Breast cancer; CESC cis rs2279817 0.908 rs3766310 chr1:17977642 A/C cg21791023 chr1:18019539 ARHGEF10L -0.68 -8.09 -0.45 2.11e-14 Neuroticism; CESC cis rs7714584 1.000 rs6579803 chr5:150255559 C/T cg22134413 chr5:150180641 NA 0.51 5.92 0.34 9.88e-9 Crohn's disease; CESC cis rs1050631 0.592 rs1631346 chr18:33709664 T/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.57 7.9 0.44 7.63e-14 Esophageal squamous cell cancer (length of survival); CESC cis rs1707322 0.752 rs7541962 chr1:46235117 G/A cg03146154 chr1:46216737 IPP 0.81 11.49 0.58 4.45e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2243480 1.000 rs6949812 chr7:65387101 G/A cg18252515 chr7:66147081 NA -1.07 -9.84 -0.52 1.12e-19 Diabetic kidney disease; CESC cis rs1801251 0.711 rs778339 chr2:233739678 T/C cg25237894 chr2:233734115 C2orf82 -0.5 -8.81 -0.48 1.67e-16 Coronary artery disease; CESC cis rs2011503 1.000 rs78883953 chr19:19630002 G/A cg11584989 chr19:19387371 SF4 0.61 7.03 0.4 1.79e-11 Bipolar disorder; CESC cis rs1595825 0.891 rs16824631 chr2:198708695 T/G cg00982548 chr2:198649783 BOLL -0.49 -5.19 -0.3 4.16e-7 Ulcerative colitis; CESC cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg20701182 chr2:24300061 SF3B14 0.94 10.39 0.54 2.01e-21 Lymphocyte counts; CESC cis rs15676 0.947 rs1572912 chr9:131565554 T/C cg00228799 chr9:131580591 ENDOG -0.42 -5.09 -0.3 6.81e-7 Blood metabolite levels; CESC cis rs34734847 0.703 rs3794215 chr12:121168083 T/C cg26008908 chr12:120799332 MSI1 0.34 5.32 0.31 2.17e-7 Mean corpuscular volume; CESC cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 11.25 0.57 2.87e-24 Hip circumference adjusted for BMI; CESC cis rs28374715 0.681 rs8037574 chr15:41630770 T/C cg18705301 chr15:41695430 NDUFAF1 -0.78 -11.24 -0.57 3.19e-24 Ulcerative colitis; CESC cis rs7481584 0.624 rs413368 chr11:3047646 C/G cg25174290 chr11:3078921 CARS -0.46 -6.4 -0.37 6.86e-10 Calcium levels; CESC cis rs796364 0.951 rs11897245 chr2:201063644 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.57 5.54 0.32 7.17e-8 Schizophrenia; CESC cis rs4604732 0.536 rs12074913 chr1:247631607 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.52 6.44 0.37 5.54e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg27125505 chr17:43679177 LOC644172 0.5 6.65 0.38 1.65e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs72772090 0.539 rs17481856 chr5:96116808 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.19 -0.3 4.24e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1832871 0.683 rs11756200 chr6:158657736 A/G cg07165851 chr6:158734300 TULP4 0.62 6.3 0.36 1.23e-9 Height; CESC trans rs864643 0.678 rs1609647 chr3:39533071 C/T cg21413947 chr1:165329957 NA 0.41 6.05 0.35 5.04e-9 Attention deficit hyperactivity disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02334771 chr22:38577945 PLA2G6 -0.48 -6.3 -0.36 1.21e-9 Asthma; CESC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -7.02 -0.4 1.84e-11 Bipolar disorder and schizophrenia; CESC trans rs7618501 0.633 rs11130234 chr3:50024758 G/T cg21659725 chr3:3221576 CRBN 0.54 7.55 0.42 7.09e-13 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.55 0.64 3.99e-32 Prudent dietary pattern; CESC cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg24110177 chr3:50126178 RBM5 -0.54 -7.36 -0.41 2.31e-12 Intelligence (multi-trait analysis); CESC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg17178900 chr1:205818956 PM20D1 0.8 12.7 0.62 3.44e-29 Menarche (age at onset); CESC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.64 5.44 0.32 1.21e-7 Depression; CESC cis rs208520 1.000 rs28773210 chr6:66993566 C/T cg07460842 chr6:66804631 NA 0.88 9.99 0.52 3.87e-20 Exhaled nitric oxide output; CESC cis rs4409675 0.549 rs72872888 chr1:28239809 G/A cg23691781 chr1:28212827 C1orf38 0.28 5.47 0.32 1.06e-7 Corneal astigmatism; CESC cis rs72634258 0.786 rs7514098 chr1:8177632 G/A cg00042356 chr1:8021962 PARK7 0.54 5.82 0.34 1.71e-8 Inflammatory bowel disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13710816 chr19:8478019 MARCH2 -0.42 -6.02 -0.35 5.72e-9 Fibrinogen levels; CESC cis rs10979 1.000 rs9376762 chr6:143887248 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs34779708 0.931 rs4934702 chr10:35323074 T/C cg04310649 chr10:35416472 CREM -0.48 -5.79 -0.34 1.96e-8 Inflammatory bowel disease;Crohn's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03670158 chr17:41323431 NBR1 0.52 6.83 0.39 5.7e-11 Gut microbiota (bacterial taxa); CESC cis rs6598163 0.517 rs10902453 chr12:132297091 G/T cg07389463 chr12:132296394 NA -0.42 -6.01 -0.35 6.07e-9 Migraine; CESC cis rs17376456 1.000 rs12188453 chr5:93560807 G/T cg21475434 chr5:93447410 FAM172A -0.82 -7.0 -0.4 2.08e-11 Diabetic retinopathy; CESC trans rs1908814 0.516 rs58869268 chr8:11797095 G/C cg15556689 chr8:8085844 FLJ10661 0.52 6.44 0.37 5.68e-10 Neuroticism; CESC cis rs2073300 0.609 rs34648279 chr20:23402935 T/G cg16736954 chr20:23401023 NAPB 0.78 5.69 0.33 3.37e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg11494091 chr17:61959527 GH2 0.73 12.66 0.61 4.86e-29 Prudent dietary pattern; CESC cis rs7772486 0.790 rs2253764 chr6:146199881 T/A cg23711669 chr6:146136114 FBXO30 0.89 13.21 0.63 5.9e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.88 0.34 1.22e-8 Tonsillectomy; CESC cis rs9399135 0.935 rs4273704 chr6:135297520 G/T cg24558204 chr6:135376177 HBS1L 0.5 6.75 0.38 9.09e-11 Red blood cell count; CESC cis rs858239 0.665 rs858305 chr7:23242830 C/G cg23682824 chr7:23144976 KLHL7 -0.43 -5.58 -0.32 5.91e-8 Cerebrospinal fluid biomarker levels; CESC cis rs6460942 0.591 rs6945587 chr7:12356992 G/A cg20607287 chr7:12443886 VWDE -0.59 -6.32 -0.36 1.12e-9 Coronary artery disease; CESC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg26314531 chr2:26401878 FAM59B -0.7 -7.87 -0.44 9.29e-14 Gut microbiome composition (summer); CESC cis rs9300255 0.722 rs12322888 chr12:123825559 A/G cg00376283 chr12:123451042 ABCB9 0.59 6.85 0.39 5.1e-11 Neutrophil percentage of white cells; CESC cis rs9291683 0.546 rs4575994 chr4:9997979 G/A cg02734326 chr4:10020555 SLC2A9 0.47 6.4 0.37 6.98e-10 Bone mineral density; CESC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.81 0.39 6.5e-11 Platelet count; CESC cis rs11676348 1.000 rs11676348 chr2:219010146 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.08 -0.35 4.18e-9 Ulcerative colitis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12377424 chr6:10412286 TFAP2A 0.49 6.4 0.37 6.86e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg20119798 chr7:94954144 PON1 -0.33 -5.27 -0.31 2.81e-7 Paraoxonase activity; CESC cis rs3092073 0.669 rs11697323 chr20:44551579 C/T cg27529037 chr20:44575021 PCIF1 0.64 9.81 0.52 1.44e-19 Intelligence (multi-trait analysis); CESC cis rs10870270 0.957 rs3753008 chr10:133785129 A/C cg26149184 chr10:133730230 NA 0.37 5.09 0.3 6.86e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs9287719 0.967 rs6712406 chr2:10754420 A/G cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg15782153 chr7:917662 C7orf20 0.52 5.47 0.32 1.02e-7 Cerebrospinal P-tau181p levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20979128 chr1:16271176 ZBTB17 0.43 5.99 0.35 6.66e-9 Fibrinogen levels; CESC cis rs9948 0.655 rs62156216 chr2:97405127 C/T cg01990225 chr2:97406019 LMAN2L -1.02 -7.77 -0.43 1.76e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs6987853 0.636 rs6988165 chr8:42351176 C/G cg09913449 chr8:42400586 C8orf40 -0.36 -5.91 -0.34 1.03e-8 Mean corpuscular hemoglobin concentration; CESC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs7107174 1.000 rs4128206 chr11:78015952 A/C cg02023728 chr11:77925099 USP35 0.37 5.46 0.32 1.07e-7 Testicular germ cell tumor; CESC cis rs8078723 0.714 rs2241244 chr17:38153554 G/C cg17467752 chr17:38218738 THRA -0.57 -8.62 -0.47 6.23e-16 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs739401 0.527 rs423236 chr11:3065916 C/T cg05729581 chr11:3078854 CARS -0.39 -5.09 -0.3 6.65e-7 Longevity; CESC cis rs6459788 0.693 rs11981578 chr7:157250133 C/T cg06271696 chr7:157225062 NA -0.37 -5.34 -0.31 1.98e-7 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs11098499 0.909 rs1546502 chr4:120235898 A/G cg24375607 chr4:120327624 NA 0.46 5.57 0.32 6.18e-8 Corneal astigmatism; CESC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg25036284 chr2:26402008 FAM59B -0.6 -6.91 -0.39 3.64e-11 Gut microbiome composition (summer); CESC cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg11812906 chr14:75593930 NEK9 -0.76 -11.47 -0.58 5.58e-25 Height; CESC cis rs863345 0.933 rs1157523 chr1:158457638 G/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.02 -0.35 5.77e-9 Pneumococcal bacteremia; CESC cis rs2361718 0.521 rs2361724 chr17:78099114 G/A cg14949292 chr17:78079608 GAA -0.35 -5.15 -0.3 5.02e-7 Yeast infection; CESC cis rs13720 0.778 rs163783 chr20:57567730 A/C cg23907860 chr20:57583709 CTSZ -0.46 -5.63 -0.33 4.67e-8 Platelet distribution width; CESC cis rs1144333 1.000 rs5745542 chr1:76365073 C/G cg10523679 chr1:76189770 ACADM 0.56 5.2 0.3 3.94e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.61 0.33 5.09e-8 Bipolar disorder; CESC cis rs9858542 0.953 rs9821311 chr3:49543656 C/T cg03060546 chr3:49711283 APEH -0.55 -6.28 -0.36 1.34e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg05973401 chr12:123451056 ABCB9 0.59 7.5 0.42 9.64e-13 Platelet count; CESC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs2644899 0.859 rs2545757 chr19:41297302 A/G cg24958765 chr19:41283667 RAB4B -0.57 -6.44 -0.37 5.52e-10 Post bronchodilator FEV1/FVC ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23940655 chr14:74227020 C14orf43 0.62 6.88 0.39 4.36e-11 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs34815098 chr7:65292254 A/C cg12463550 chr7:65579703 CRCP 0.68 5.74 0.33 2.59e-8 Diabetic kidney disease; CESC cis rs10838687 0.736 rs16938581 chr11:47271039 G/A cg25783544 chr11:47291846 MADD 0.55 6.28 0.36 1.38e-9 Proinsulin levels; CESC cis rs950776 0.593 rs680244 chr15:78871288 T/C cg06917634 chr15:78832804 PSMA4 -0.59 -7.85 -0.43 1.01e-13 Sudden cardiac arrest; CESC cis rs9902453 0.765 rs2617883 chr17:28120488 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.15e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3733585 0.699 rs7663079 chr4:9966771 T/C cg00071950 chr4:10020882 SLC2A9 -0.7 -11.44 -0.57 6.82e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.34 0.36 9.63e-10 Prudent dietary pattern; CESC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg18876405 chr7:65276391 NA 0.5 6.87 0.39 4.63e-11 Aortic root size; CESC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg24250549 chr1:154909240 PMVK 0.75 11.19 0.57 4.8e-24 Prostate cancer; CESC cis rs17666538 0.710 rs11987001 chr8:630755 T/C cg02524346 chr8:600233 NA 0.8 5.62 0.33 4.76e-8 IgG glycosylation; CESC cis rs25645 0.800 rs11078935 chr17:38192137 T/G cg17344932 chr17:38183730 MED24;SNORD124 0.56 7.72 0.43 2.33e-13 Myeloid white cell count; CESC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.18 0.4 6.93e-12 Height; CESC cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg25174290 chr11:3078921 CARS 0.51 7.14 0.4 8.98e-12 Longevity; CESC cis rs5769707 0.681 rs2071902 chr22:50034538 G/C cg20744362 chr22:50050164 C22orf34 0.38 5.19 0.3 4.24e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg18876405 chr7:65276391 NA 0.48 6.31 0.36 1.16e-9 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27289501 chr12:77378460 NA 0.49 6.48 0.37 4.53e-10 Fibrinogen levels; CESC cis rs617219 0.853 rs1664552 chr5:78438492 A/C cg22188827 chr5:78429774 NA -0.43 -5.1 -0.3 6.62e-7 Betaine levels in individuals undergoing cardiac evaluation; CESC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg15145296 chr3:125709740 NA -0.56 -5.91 -0.34 1.06e-8 Blood pressure (smoking interaction); CESC cis rs4523957 0.651 rs7212342 chr17:2084305 A/G cg16513277 chr17:2031491 SMG6 -0.71 -10.17 -0.53 1.04e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7177699 0.567 rs67745769 chr15:79124832 G/A cg04896959 chr15:78267971 NA 0.33 5.12 0.3 5.82e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs9457247 0.967 rs424185 chr6:167410907 C/T cg23791538 chr6:167370224 RNASET2 -0.61 -8.81 -0.48 1.71e-16 Crohn's disease; CESC cis rs6933660 0.683 rs8180642 chr6:151756612 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.44 -5.63 -0.33 4.51e-8 Menarche (age at onset); CESC cis rs6752107 1.000 rs2241880 chr2:234183368 A/G cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.37 5.56 0.32 6.49e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.83 8.12 0.45 1.74e-14 Platelet count; CESC cis rs4662945 0.762 rs1453155 chr2:130226369 G/A cg05962382 chr2:130345044 NA -0.36 -5.2 -0.3 4.03e-7 Response to cytidine analogues (gemcitabine); CESC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg17372223 chr3:52568218 NT5DC2 0.4 5.94 0.34 8.99e-9 Electroencephalogram traits; CESC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg27170947 chr2:26402098 FAM59B 0.87 9.89 0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs9527 0.637 rs7085104 chr10:104628873 A/G cg15744005 chr10:104629667 AS3MT -0.42 -6.28 -0.36 1.38e-9 Arsenic metabolism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13226924 chr17:2275664 SGSM2 0.49 6.44 0.37 5.6e-10 Fibrinogen levels; CESC cis rs2011503 0.941 rs80146298 chr19:19426317 C/T cg11584989 chr19:19387371 SF4 0.68 7.54 0.42 7.41e-13 Bipolar disorder; CESC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs9902453 0.765 rs2628167 chr17:28064498 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.76 -10.16 -0.53 1.04e-20 Coffee consumption (cups per day); CESC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg18252515 chr7:66147081 NA 0.48 6.47 0.37 4.62e-10 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14162086 chr9:129279673 NA -0.59 -7.11 -0.4 1.07e-11 Gut microbiome composition (summer); CESC cis rs2797160 1.000 rs1739347 chr6:126014157 C/T cg05901451 chr6:126070800 HEY2 0.48 6.8 0.39 6.78e-11 Endometrial cancer; CESC cis rs1707322 0.717 rs12023439 chr1:46104636 C/T cg03146154 chr1:46216737 IPP 0.81 11.48 0.58 5.05e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6570726 0.935 rs385185 chr6:145814992 A/G cg23711669 chr6:146136114 FBXO30 0.82 12.29 0.6 8.74e-28 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01563148 chr8:145623258 CPSF1 -0.57 -6.75 -0.38 9.16e-11 Gut microbiome composition (summer); CESC cis rs1003719 0.715 rs2051398 chr21:38550258 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.55 7.37 0.41 2.15e-12 Eye color traits; CESC cis rs561341 1.000 rs8064843 chr17:30245744 A/G cg00745463 chr17:30367425 LRRC37B -0.5 -5.23 -0.31 3.36e-7 Hip circumference adjusted for BMI; CESC cis rs854765 0.547 rs28537385 chr17:17902135 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.83 0.48 1.44e-16 Total body bone mineral density; CESC cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg01579765 chr21:45077557 HSF2BP -0.56 -9.74 -0.51 2.37e-19 Mean corpuscular volume; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg26614578 chr12:113623930 C12orf52;DDX54 -0.48 -6.36 -0.36 8.99e-10 Height; CESC cis rs9818758 0.607 rs10049462 chr3:49309684 C/T cg00383909 chr3:49044727 WDR6 0.8 6.13 0.35 3.1e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11582617 chr6:158589302 SERAC1;GTF2H5 0.61 7.25 0.41 4.58e-12 Gut microbiome composition (summer); CESC cis rs7818688 0.697 rs78777150 chr8:95984411 C/G cg16049864 chr8:95962084 TP53INP1 0.55 5.56 0.32 6.66e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7927771 0.524 rs7107922 chr11:47669289 C/A cg18512352 chr11:47633146 NA 0.34 5.28 0.31 2.74e-7 Subjective well-being; CESC cis rs2777491 0.540 rs7164684 chr15:41705008 G/T cg20272979 chr15:41787780 ITPKA 0.42 5.18 0.3 4.32e-7 Ulcerative colitis; CESC cis rs7660520 0.524 rs4862101 chr4:183733177 T/C cg12524338 chr4:183729343 NA 0.54 5.12 0.3 5.84e-7 Pediatric autoimmune diseases; CESC cis rs28386778 0.700 rs12449555 chr17:62003982 T/A cg07677032 chr17:61819896 STRADA -0.51 -6.65 -0.38 1.65e-10 Prudent dietary pattern; CESC cis rs2228479 0.702 rs11649501 chr16:89850957 A/T cg04013166 chr16:89971882 TCF25 0.78 6.68 0.38 1.43e-10 Skin colour saturation; CESC cis rs55788414 0.932 rs12102293 chr16:81181607 T/C cg06400318 chr16:81190750 PKD1L2 -0.6 -7.13 -0.4 9.29e-12 Left ventricular obstructive tract defect (maternal effect); CESC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6933660 0.800 rs2046371 chr6:151754744 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.44 -5.62 -0.33 4.93e-8 Menarche (age at onset); CESC cis rs6121246 0.909 rs6060870 chr20:30303299 C/T cg13852791 chr20:30311386 BCL2L1 0.79 8.37 0.46 3.41e-15 Mean corpuscular hemoglobin; CESC cis rs74181299 0.750 rs58342673 chr2:65347584 T/C cg05010058 chr2:65284262 CEP68 -0.31 -5.15 -0.3 5.01e-7 Pulse pressure; CESC trans rs10506458 1.000 rs73127086 chr12:63415626 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.31 -18.2 -0.75 1.42e-48 Hemostatic factors and hematological phenotypes; CESC cis rs4604732 0.642 rs4472786 chr1:247636518 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.46 6.51 0.37 3.81e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9611565 0.694 rs202618 chr22:41822856 A/G cg06634786 chr22:41940651 POLR3H 0.71 7.17 0.4 7.6e-12 Vitiligo; CESC trans rs10242455 0.702 rs58348977 chr7:99188014 G/A cg09045935 chr12:6379348 NA 0.89 7.53 0.42 8.12e-13 Blood metabolite levels; CESC cis rs9303401 0.614 rs35245220 chr17:56510305 G/A cg25039879 chr17:56429692 SUPT4H1 0.53 5.19 0.3 4.16e-7 Cognitive test performance; CESC cis rs1642645 0.872 rs3856258 chr1:42473397 A/G cg16685388 chr1:42384056 HIVEP3 0.36 5.08 0.3 7.27e-7 Left ventricular obstructive tract defect (maternal effect); CESC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg25427524 chr10:38739819 LOC399744 -0.67 -9.8 -0.52 1.46e-19 Extrinsic epigenetic age acceleration; CESC cis rs1559088 0.948 rs7259333 chr19:33579128 T/C cg17764715 chr19:33622953 WDR88 0.51 6.69 0.38 1.28e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs11098499 0.954 rs4577559 chr4:120404043 T/G cg25214090 chr10:38739885 LOC399744 0.72 10.18 0.53 9.16e-21 Corneal astigmatism; CESC cis rs78456975 1.000 rs13413096 chr2:1553588 G/A cg01028140 chr2:1542097 TPO -0.51 -5.3 -0.31 2.48e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4853012 0.887 rs2280642 chr2:74358252 T/A cg20891558 chr2:74357851 NA 0.84 11.48 0.58 4.88e-25 Gestational age at birth (maternal effect); CESC cis rs1568889 1.000 rs12797155 chr11:28290866 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.67 0.55 2.45e-22 Bipolar disorder; CESC cis rs7116495 0.609 rs7121080 chr11:71703935 G/A cg10381502 chr11:71823885 C11orf51 -1.16 -7.94 -0.44 5.77e-14 Severe influenza A (H1N1) infection; CESC cis rs7208859 0.623 rs9890855 chr17:29111707 G/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6032067 1.000 rs13038434 chr20:43888106 G/A cg10761708 chr20:43804764 PI3 0.48 5.48 0.32 9.91e-8 Blood protein levels; CESC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg12667521 chr19:29218732 NA 0.48 6.4 0.37 6.97e-10 Methadone dose in opioid dependence; CESC cis rs9611565 0.694 rs5758347 chr22:41821019 G/T cg06481639 chr22:41940642 POLR3H 0.64 6.41 0.37 6.73e-10 Vitiligo; CESC cis rs12681288 0.523 rs6983944 chr8:955147 A/G cg15309053 chr8:964076 NA 0.51 8.68 0.47 4e-16 Schizophrenia; CESC cis rs7089973 0.584 rs758585 chr10:116582560 C/A cg23260525 chr10:116636907 FAM160B1 0.4 7.51 0.42 9.07e-13 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2236918 0.710 rs2797603 chr1:242029027 T/G cg17736920 chr1:242011382 EXO1 0.55 7.02 0.4 1.89e-11 Menopause (age at onset); CESC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg09365446 chr1:150670422 GOLPH3L 0.38 5.03 0.3 9.22e-7 Melanoma; CESC cis rs7178572 0.568 rs4886850 chr15:77404160 G/C cg22256960 chr15:77711686 NA -0.54 -6.76 -0.38 8.67e-11 Type 2 diabetes; CESC cis rs9916302 0.861 rs8079590 chr17:37426201 T/C cg00129232 chr17:37814104 STARD3 -0.53 -6.89 -0.39 4.12e-11 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg17949981 chr6:28129498 ZNF389 0.46 5.77 0.33 2.16e-8 Depression; CESC cis rs6502955 1.000 rs6502955 chr17:6344127 C/G cg23465990 chr17:6347153 FAM64A -0.53 -6.29 -0.36 1.31e-9 Life satisfaction; CESC cis rs7264396 0.790 rs6058283 chr20:34216276 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.51 -0.58 4.04e-25 Total cholesterol levels; CESC cis rs7208859 0.573 rs56031503 chr17:29075665 T/C cg13385521 chr17:29058706 SUZ12P 0.82 6.69 0.38 1.3e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10779751 0.734 rs2791648 chr1:11132638 G/T cg08854313 chr1:11322531 MTOR 0.76 10.24 0.53 5.91e-21 Body mass index; CESC cis rs2204008 0.604 rs11172718 chr12:38069819 T/C cg26384229 chr12:38710491 ALG10B 0.66 9.39 0.5 2.96e-18 Bladder cancer; CESC cis rs3126085 0.935 rs4326625 chr1:152223996 C/T cg03465714 chr1:152285911 FLG -0.45 -5.69 -0.33 3.29e-8 Atopic dermatitis; CESC cis rs6502050 0.749 rs7406163 chr17:80086389 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.53 0.37 3.27e-10 Life satisfaction; CESC cis rs9467603 0.547 rs7774567 chr6:25425526 C/T cg21479132 chr6:26055353 NA 0.72 5.43 0.32 1.26e-7 Intelligence (multi-trait analysis); CESC cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg09165964 chr15:75287851 SCAMP5 -0.58 -6.91 -0.39 3.66e-11 Blood trace element (Zn levels); CESC cis rs7833790 0.777 rs1005850 chr8:82692255 G/A cg27398817 chr8:82754497 SNX16 -0.55 -6.74 -0.38 1e-10 Diastolic blood pressure; CESC cis rs7851660 0.967 rs3021526 chr9:100617021 C/T cg13688889 chr9:100608707 NA -0.69 -10.57 -0.54 4.92e-22 Strep throat; CESC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg14926445 chr8:58193284 C8orf71 -0.5 -5.44 -0.32 1.22e-7 Developmental language disorder (linguistic errors); CESC cis rs861020 0.630 rs686582 chr1:210008673 A/C cg05527609 chr1:210001259 C1orf107 0.75 9.99 0.52 3.88e-20 Orofacial clefts; CESC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg14646974 chr10:38645378 HSD17B7P2 -0.42 -5.07 -0.3 7.59e-7 Breast cancer; CESC cis rs938554 0.542 rs7678287 chr4:10000501 A/G cg11266682 chr4:10021025 SLC2A9 0.47 6.25 0.36 1.6e-9 Blood metabolite levels; CESC cis rs10463316 0.862 rs7700650 chr5:150776473 C/T cg03212797 chr5:150827313 SLC36A1 -0.45 -5.94 -0.34 9.07e-9 Metabolite levels (Pyroglutamine); CESC cis rs138880 0.542 rs9616393 chr22:50314809 A/G cg02269571 chr22:50332266 NA 0.59 6.14 0.35 3.04e-9 Schizophrenia; CESC cis rs2115630 0.691 rs8040066 chr15:85176465 G/C cg12501888 chr15:85177176 SCAND2 -0.5 -6.73 -0.38 1.07e-10 P wave terminal force; CESC cis rs2425143 0.915 rs2378408 chr20:34367732 T/C cg23207816 chr20:34252616 CPNE1;RBM12 -0.72 -6.67 -0.38 1.52e-10 Blood protein levels; CESC trans rs11098499 0.874 rs7661020 chr4:120106982 T/C cg25214090 chr10:38739885 LOC399744 0.57 7.53 0.42 7.93e-13 Corneal astigmatism; CESC cis rs7259376 0.905 rs56027264 chr19:22554354 T/C cg02657401 chr19:22469223 NA -0.25 -5.05 -0.3 8.34e-7 Menopause (age at onset); CESC trans rs9467711 0.606 rs34104395 chr6:26478252 C/T cg06606381 chr12:133084897 FBRSL1 -0.96 -7.02 -0.4 1.91e-11 Autism spectrum disorder or schizophrenia; CESC cis rs12477438 0.834 rs1563108 chr2:99701153 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -9.85 -0.52 1.06e-19 Chronic sinus infection; CESC cis rs77972916 0.611 rs6709988 chr2:43601317 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.63 -6.06 -0.35 4.59e-9 Granulocyte percentage of myeloid white cells; CESC cis rs2742417 0.565 rs2673031 chr3:45756986 A/G cg04837898 chr3:45731254 SACM1L -0.48 -6.55 -0.37 2.96e-10 Response to anti-depressant treatment in major depressive disorder; CESC cis rs9616064 0.531 rs66909472 chr22:47050210 G/A cg25730555 chr22:47059586 GRAMD4 0.46 5.73 0.33 2.71e-8 Urate levels in obese individuals; CESC trans rs11989868 1.000 rs920613 chr8:14543372 C/T cg22006392 chr17:927457 ABR -0.43 -6.0 -0.35 6.42e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12445378 chr8:48741753 PRKDC -0.57 -6.67 -0.38 1.45e-10 Gut microbiome composition (summer); CESC cis rs3126085 0.935 rs1496051 chr1:152164923 G/A cg26876637 chr1:152193138 HRNR 0.44 5.11 0.3 6.32e-7 Atopic dermatitis; CESC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.43 5.76 0.33 2.37e-8 Lymphocyte counts; CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg07167872 chr1:205819463 PM20D1 0.83 15.19 0.68 6.31e-38 Menarche (age at onset); CESC cis rs6537837 0.838 rs12023950 chr1:110099858 T/C cg05049280 chr1:110155535 GNAT2 0.41 5.79 0.33 2.02e-8 Major depressive disorder; CESC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.37 0.31 1.71e-7 Bipolar disorder; CESC cis rs1904096 0.506 rs11097408 chr4:95165662 T/C cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.61 -0.51 5.84e-19 Type 2 diabetes; CESC cis rs11696501 0.688 rs6073861 chr20:44325708 G/A cg11783356 chr20:44313418 WFDC10B -0.31 -5.08 -0.3 7.02e-7 Brain structure; CESC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC trans rs11625487 0.957 rs28820314 chr14:77963272 A/C cg20065768 chr16:29796685 NA 0.46 6.1 0.35 3.76e-9 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg11764359 chr7:65958608 NA 0.81 11.87 0.59 2.48e-26 Aortic root size; CESC cis rs17376456 0.877 rs10065056 chr5:93380123 G/T cg25358565 chr5:93447407 FAM172A 1.11 11.1 0.56 9.57e-24 Diabetic retinopathy; CESC cis rs6835098 0.924 rs13138282 chr4:174120906 C/T cg08422745 chr4:174089978 GALNT7 0.72 9.25 0.49 7.78e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs9611565 0.512 rs5758439 chr22:42131762 C/T cg06634786 chr22:41940651 POLR3H 0.68 6.72 0.38 1.13e-10 Vitiligo; CESC cis rs2228479 0.557 rs57071566 chr16:89889327 T/G cg00800038 chr16:89945340 TCF25 -0.83 -6.64 -0.38 1.77e-10 Skin colour saturation; CESC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg17372223 chr3:52568218 NT5DC2 0.42 6.42 0.37 6.33e-10 Bipolar disorder; CESC cis rs3733585 0.579 rs4235356 chr4:10123106 G/C cg11266682 chr4:10021025 SLC2A9 -0.57 -10.59 -0.55 4.26e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1707322 0.721 rs10890333 chr1:46100322 T/C cg03146154 chr1:46216737 IPP 0.82 11.44 0.57 7.04e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10242455 0.867 rs2740562 chr7:99319157 G/A cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs11785400 0.731 rs4644221 chr8:143736984 C/T cg24634471 chr8:143751801 JRK -0.44 -5.77 -0.33 2.19e-8 Schizophrenia; CESC cis rs11122272 0.735 rs2808586 chr1:231515559 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1062746 0.711 rs8056833 chr16:87378388 G/C cg02258303 chr16:87377426 FBXO31 -0.49 -6.17 -0.35 2.5e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26029786 chr10:65280952 REEP3 0.55 6.06 0.35 4.72e-9 Gut microbiome composition (summer); CESC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg20790798 chr5:1857306 NA -0.39 -5.13 -0.3 5.58e-7 Cardiovascular disease risk factors; CESC cis rs10885582 0.754 rs10885574 chr10:116296487 C/T cg17056676 chr10:116301354 ABLIM1 -0.28 -5.16 -0.3 4.84e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs977987 0.750 rs4888407 chr16:75432390 T/C cg03315344 chr16:75512273 CHST6 0.41 5.98 0.34 7.36e-9 Dupuytren's disease; CESC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg25036284 chr2:26402008 FAM59B 0.86 9.42 0.5 2.32e-18 Gut microbiome composition (summer); CESC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg05863683 chr7:1912471 MAD1L1 -0.45 -6.83 -0.39 5.81e-11 Bipolar disorder and schizophrenia; CESC cis rs1008375 1.000 rs6818639 chr4:17633049 A/G cg02297831 chr4:17616191 MED28 0.54 6.85 0.39 5.05e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg11644478 chr21:40555479 PSMG1 0.82 12.28 0.6 9.99e-28 Cognitive function; CESC cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg26408565 chr15:76604113 ETFA -0.41 -6.02 -0.35 5.86e-9 Blood metabolite levels; CESC cis rs8020095 0.528 rs7152422 chr14:67392257 T/C cg19548862 chr14:67692701 FAM71D -0.5 -6.1 -0.35 3.83e-9 Depression (quantitative trait); CESC cis rs72627123 0.867 rs117818304 chr14:74474396 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.76 5.04 0.3 8.56e-7 Morning vs. evening chronotype; CESC cis rs9943753 0.525 rs7957928 chr12:109835975 C/G cg19025524 chr12:109796872 NA -0.48 -6.87 -0.39 4.51e-11 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02408009 chr15:28422194 HERC2 -0.55 -6.51 -0.37 3.78e-10 Gut microbiome composition (summer); CESC cis rs62158211 0.565 rs62158212 chr2:114106326 A/G cg17784749 chr2:114082611 LOC440839 0.51 6.38 0.37 7.7e-10 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CESC cis rs11190604 1.000 rs2495734 chr10:102338686 G/A cg07080220 chr10:102295463 HIF1AN 0.6 5.52 0.32 7.97e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14132868 chr11:18343680 HPS5;GTF2H1 0.58 6.59 0.38 2.32e-10 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 11.59 0.58 2.05e-25 Personality dimensions; CESC cis rs644799 0.965 rs502521 chr11:95533557 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.61 0.38 2.07e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10818894 0.772 rs10120705 chr9:126692600 T/G cg16191174 chr9:126692580 DENND1A 0.62 8.0 0.44 3.99e-14 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); CESC cis rs9611565 0.559 rs132765 chr22:42008068 A/G cg17376030 chr22:41985996 PMM1 -0.82 -9.02 -0.48 3.81e-17 Vitiligo; CESC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg02187348 chr16:89574699 SPG7 0.66 9.18 0.49 1.27e-17 Multiple myeloma (IgH translocation); CESC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg26343298 chr8:95960752 TP53INP1 0.32 5.29 0.31 2.59e-7 Type 2 diabetes; CESC cis rs1062177 1.000 rs973529 chr5:151188158 T/C cg12924095 chr5:151150029 G3BP1 0.49 6.5 0.37 3.86e-10 Preschool internalizing problems; CESC cis rs2777491 0.915 rs28526381 chr15:41621842 A/C cg02330683 chr15:41787940 ITPKA 0.45 6.56 0.37 2.73e-10 Ulcerative colitis; CESC cis rs208520 0.507 rs9453585 chr6:66796668 C/T cg07460842 chr6:66804631 NA -1.1 -26.24 -0.85 1.17e-75 Exhaled nitric oxide output; CESC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg08736216 chr1:53307985 ZYG11A -0.39 -6.55 -0.37 3.01e-10 Monocyte count; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03045169 chr17:62503007 CCDC45;DDX5 0.45 6.07 0.35 4.45e-9 Systemic lupus erythematosus; CESC cis rs7191439 0.858 rs2340973 chr16:88773396 G/A cg27087555 chr16:88793112 FAM38A -1.25 -9.87 -0.52 8.84e-20 Plateletcrit; CESC cis rs4969178 0.965 rs12944051 chr17:76395856 C/T cg20026190 chr17:76395443 PGS1 -0.46 -7.28 -0.41 3.83e-12 HDL cholesterol levels; CESC cis rs2235544 0.554 rs605272 chr1:54467026 T/A cg25741118 chr1:54482237 LDLRAD1 0.24 5.8 0.34 1.91e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.87e-8 Lung cancer; CESC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg14393609 chr7:65229607 NA 0.48 6.35 0.36 9.51e-10 Calcium levels; CESC cis rs12142240 0.698 rs6683192 chr1:46830257 C/T cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 3.02e-14 Menopause (age at onset); CESC cis rs1546924 0.647 rs197422 chr1:112317512 C/A cg23955903 chr1:112298873 DDX20;C1orf183 0.43 5.45 0.32 1.16e-7 Body mass index; CESC cis rs2197308 0.610 rs10880837 chr12:37864924 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.39 0.54 1.88e-21 Morning vs. evening chronotype; CESC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg24829409 chr8:58192753 C8orf71 -0.7 -7.71 -0.43 2.5e-13 Developmental language disorder (linguistic errors); CESC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.93e-7 Lung cancer; CESC cis rs9905704 0.831 rs12949598 chr17:56707245 C/T cg12560992 chr17:57184187 TRIM37 0.59 6.98 0.39 2.34e-11 Testicular germ cell tumor; CESC cis rs2929278 0.617 rs12908467 chr15:44047430 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.53 -6.99 -0.39 2.19e-11 Schizophrenia; CESC cis rs1927790 0.727 rs16953068 chr13:96949327 C/G cg02571835 chr13:96230311 CLDN10 -0.39 -5.67 -0.33 3.71e-8 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06058891 chr20:45523134 EYA2 -0.58 -7.21 -0.4 5.76e-12 Gut microbiome composition (summer); CESC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg20203395 chr5:56204925 C5orf35 -0.43 -5.03 -0.3 9.1e-7 Initial pursuit acceleration; CESC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs920590 0.684 rs7461774 chr8:19666645 G/A cg03894339 chr8:19674705 INTS10 0.7 7.9 0.44 7.58e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs4237845 0.735 rs11172375 chr12:58291574 G/C cg00677455 chr12:58241039 CTDSP2 0.62 7.7 0.43 2.7e-13 Intelligence (multi-trait analysis); CESC cis rs7520050 0.966 rs9429183 chr1:46524582 G/A cg03146154 chr1:46216737 IPP -0.44 -5.73 -0.33 2.66e-8 Red blood cell count;Reticulocyte count; CESC cis rs7777484 0.571 rs2527686 chr7:2834413 G/A cg18446336 chr7:2847575 GNA12 -0.4 -6.68 -0.38 1.39e-10 Height; CESC cis rs12142240 0.698 rs112089006 chr1:46812360 C/T cg10495392 chr1:46806563 NSUN4 0.57 6.29 0.36 1.33e-9 Menopause (age at onset); CESC cis rs73206853 0.841 rs56324794 chr12:111086449 T/A cg12870014 chr12:110450643 ANKRD13A 0.63 5.23 0.31 3.5e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs470119 1.000 rs12148 chr22:50962208 T/G cg12969734 chr22:50962224 SCO2 0.39 6.05 0.35 4.99e-9 Mean corpuscular hemoglobin; CESC cis rs9488822 0.636 rs11153592 chr6:116330574 T/C cg15226275 chr6:116381976 FRK 0.24 6.15 0.35 2.9e-9 Cholesterol, total;LDL cholesterol; CESC cis rs7089973 0.604 rs11196929 chr10:116582080 G/C cg03647239 chr10:116582469 FAM160B1 0.42 5.2 0.3 4.07e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6690583 0.623 rs2028304 chr1:85488030 G/A cg22153463 chr1:85462885 MCOLN2 -0.77 -7.83 -0.43 1.19e-13 Serum sulfate level; CESC cis rs2235544 0.613 rs651381 chr1:54450998 G/A cg25741118 chr1:54482237 LDLRAD1 0.24 6.05 0.35 4.9e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs7188697 0.922 rs37036 chr16:58553348 T/C cg02549819 chr16:58548995 SETD6 -0.41 -5.03 -0.3 9.12e-7 QT interval; CESC cis rs992157 0.764 rs2015863 chr2:219185161 C/T cg00012203 chr2:219082015 ARPC2 -0.59 -7.28 -0.41 3.84e-12 Colorectal cancer; CESC cis rs1975974 0.590 rs113830378 chr17:21744147 G/C cg18423549 chr17:21743878 NA -0.68 -9.45 -0.5 1.84e-18 Psoriasis; CESC cis rs12295403 1.000 rs12295403 chr11:18689653 G/T cg09887367 chr11:18690185 NA -0.37 -5.41 -0.32 1.42e-7 Ovarian reserve; CESC cis rs7580658 0.680 rs6710535 chr2:128190960 C/G cg10021288 chr2:128175891 PROC 0.37 5.52 0.32 8.23e-8 Protein C levels; CESC cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg05234568 chr11:5960015 NA -0.64 -7.52 -0.42 8.7e-13 DNA methylation (variation); CESC trans rs561341 1.000 rs55736640 chr17:30333848 G/A cg20587970 chr11:113659929 NA -1.5 -18.7 -0.75 2.41e-50 Hip circumference adjusted for BMI; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24529269 chr15:89164510 AEN -0.49 -6.5 -0.37 3.94e-10 Fibrinogen levels; CESC cis rs9896933 0.623 rs77166830 chr17:80833525 T/C cg15664640 chr17:80829946 TBCD -0.53 -5.62 -0.33 4.83e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg12311346 chr5:56204834 C5orf35 -0.44 -5.53 -0.32 7.59e-8 Coronary artery disease; CESC cis rs7208859 0.623 rs55814012 chr17:29077697 T/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs16917546 0.935 rs12766391 chr10:64441204 C/T cg03961010 chr10:64397487 ZNF365 -0.35 -5.85 -0.34 1.47e-8 Basal cell carcinoma; CESC trans rs6934970 0.860 rs4591889 chr6:112983901 T/A cg05146922 chr2:10634174 NA -0.37 -6.17 -0.35 2.53e-9 Bipolar disorder (body mass index interaction); CESC cis rs4969178 0.895 rs2292640 chr17:76396610 G/A cg05887092 chr17:76393375 PGS1 0.58 9.22 0.49 9.9e-18 HDL cholesterol levels; CESC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.9e-10 Life satisfaction; CESC cis rs77216612 0.835 rs56692845 chr12:12887811 C/T cg09462578 chr12:12878428 APOLD1 -0.97 -14.4 -0.66 4.1e-35 Lymphocyte counts; CESC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg21361702 chr7:150065534 REPIN1 0.53 5.52 0.32 8.11e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs66573146 0.539 rs56659624 chr4:7069377 G/C cg26116260 chr4:7069785 GRPEL1 -0.82 -6.06 -0.35 4.63e-9 Granulocyte percentage of myeloid white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02189121 chr6:79943796 HMGN3 -0.57 -6.42 -0.37 6.35e-10 Gut microbiome composition (summer); CESC cis rs1801251 1.000 rs4973054 chr2:233710713 G/C cg25237894 chr2:233734115 C2orf82 -0.47 -8.33 -0.46 4.29e-15 Coronary artery disease; CESC cis rs5760092 0.755 rs4585126 chr22:24270005 T/C cg18538332 chr22:24372958 LOC391322 0.68 8.97 0.48 5.71e-17 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs10791097 0.694 rs10160281 chr11:130742788 T/C cg12179176 chr11:130786555 SNX19 0.65 10.05 0.53 2.42e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs8077889 0.917 rs72836553 chr17:41909851 A/G cg26893861 chr17:41843967 DUSP3 0.83 9.9 0.52 7.45e-20 Triglycerides; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg26291698 chr6:43445274 TJAP1 0.46 6.06 0.35 4.7e-9 Post-traumatic stress disorder; CESC cis rs9611565 0.512 rs139566 chr22:42199277 A/G cg17376030 chr22:41985996 PMM1 0.78 8.4 0.46 2.79e-15 Vitiligo; CESC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.55 0.64 3.99e-32 Prudent dietary pattern; CESC cis rs6665290 0.835 rs7549586 chr1:227214566 A/G cg10327440 chr1:227177885 CDC42BPA -1.11 -21.89 -0.8 2.41e-61 Myeloid white cell count; CESC cis rs9457247 0.765 rs2237276 chr6:167442115 C/T cg23791538 chr6:167370224 RNASET2 -0.54 -7.37 -0.41 2.19e-12 Crohn's disease; CESC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg11764359 chr7:65958608 NA 0.82 11.81 0.59 3.86e-26 Aortic root size; CESC cis rs1577917 1.000 rs7756203 chr6:86627707 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.33 2.14e-8 Response to antipsychotic treatment; CESC cis rs8070128 0.637 rs4925133 chr17:17884801 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.51 7.06 0.4 1.46e-11 Total body bone mineral density; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25631650 chr19:633157 POLRMT 0.47 6.18 0.35 2.35e-9 Systemic lupus erythematosus; CESC cis rs703842 1.000 rs8181644 chr12:58173466 A/G cg18357645 chr12:58087776 OS9 -0.39 -5.37 -0.31 1.74e-7 Multiple sclerosis; CESC cis rs7818382 1.000 rs7818382 chr8:96054000 C/T cg13393036 chr8:95962371 TP53INP1 -0.39 -7.97 -0.44 4.71e-14 Alzheimer's disease (late onset); CESC cis rs11098499 0.863 rs11947234 chr4:120474859 A/G cg09307838 chr4:120376055 NA 0.91 12.68 0.61 4e-29 Corneal astigmatism; CESC cis rs12190007 0.517 rs3006210 chr6:169828915 C/T cg15038512 chr6:170123185 PHF10 -0.51 -7.29 -0.41 3.67e-12 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08944318 chr10:15139147 RPP38;C10orf111 0.61 7.36 0.41 2.27e-12 Gut microbiome composition (summer); CESC cis rs7524258 0.900 rs7544004 chr1:7314529 A/C cg07173049 chr1:7289937 CAMTA1 0.32 5.04 0.3 8.77e-7 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs847577 0.630 rs6969384 chr7:97732842 C/T cg21770322 chr7:97807741 LMTK2 0.83 14.06 0.65 6.11e-34 Breast cancer; CESC cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg11366901 chr6:160182831 ACAT2 0.81 10.03 0.52 2.85e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.97 0.8 1.29e-61 Prudent dietary pattern; CESC cis rs9916302 0.706 rs4795375 chr17:37662932 T/C cg07936489 chr17:37558343 FBXL20 -0.91 -9.97 -0.52 4.37e-20 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01939664 chr1:33722135 ZNF362 0.63 7.87 0.44 8.99e-14 Gut microbiome composition (summer); CESC cis rs2929278 0.617 rs533143 chr15:44188854 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.39 6.08 0.35 4.22e-9 Schizophrenia; CESC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg19592336 chr6:28129416 ZNF389 0.54 6.94 0.39 3e-11 Parkinson's disease; CESC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg11764359 chr7:65958608 NA -0.71 -9.5 -0.5 1.32e-18 Aortic root size; CESC cis rs11608355 0.515 rs4766609 chr12:109973297 A/G cg05360138 chr12:110035743 NA 0.82 8.91 0.48 8.24e-17 Neuroticism; CESC cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg06108461 chr20:60628389 TAF4 -0.64 -8.61 -0.47 6.58e-16 Body mass index; CESC cis rs36051895 0.659 rs7862042 chr9:5268139 G/A cg02405213 chr9:5042618 JAK2 -0.47 -5.54 -0.32 7.13e-8 Pediatric autoimmune diseases; CESC cis rs7208859 0.673 rs216435 chr17:28922737 G/T cg14008862 chr17:28927542 LRRC37B2 0.68 6.06 0.35 4.57e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1577917 0.771 rs4351223 chr6:86237797 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.55 7.67 0.43 3.2e-13 Response to antipsychotic treatment; CESC trans rs66573146 0.808 rs73202120 chr4:7005588 A/G cg07817883 chr1:32538562 TMEM39B 0.81 6.2 0.36 2.19e-9 Granulocyte percentage of myeloid white cells; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg27367768 chr5:171615456 STK10 -0.4 -6.12 -0.35 3.36e-9 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00437399 chr15:40886176 CASC5 -0.44 -6.25 -0.36 1.66e-9 Gut microbiota (bacterial taxa); CESC cis rs1577917 0.771 rs2783171 chr6:86382765 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.55 7.36 0.41 2.29e-12 Response to antipsychotic treatment; CESC cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.83 8.74 0.47 2.63e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg08888203 chr3:10149979 C3orf24 0.49 6.24 0.36 1.75e-9 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01193506 chr22:38004378 GGA1 -0.55 -6.17 -0.35 2.6e-9 Gut microbiome composition (summer); CESC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg17949981 chr6:28129498 ZNF389 0.43 5.58 0.32 5.97e-8 Depression; CESC cis rs1707322 0.964 rs796773 chr1:46564475 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.63 -0.33 4.67e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06829293 chr19:11201108 LDLR -0.58 -6.72 -0.38 1.11e-10 Gut microbiome composition (summer); CESC cis rs10870270 1.000 rs6560694 chr10:133773448 G/A cg26149184 chr10:133730230 NA 0.38 5.14 0.3 5.22e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1559088 0.576 rs10407255 chr19:33581150 A/G cg17764715 chr19:33622953 WDR88 -0.61 -9.26 -0.49 7.06e-18 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg04553112 chr3:125709451 NA -0.56 -6.33 -0.36 1.07e-9 Blood pressure (smoking interaction); CESC cis rs9399135 0.967 rs6902954 chr6:135313994 C/A cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24108215 chr1:39174820 NA -0.43 -6.34 -0.36 1.01e-9 Gut microbiota (bacterial taxa); CESC cis rs3008870 0.755 rs1925409 chr1:67365089 C/T cg02640540 chr1:67518911 SLC35D1 -0.45 -5.56 -0.32 6.61e-8 Lymphocyte percentage of white cells; CESC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg22907277 chr7:1156413 C7orf50 0.49 5.68 0.33 3.5e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg18769074 chr3:133464867 TF -0.28 -5.35 -0.31 1.9e-7 Iron status biomarkers; CESC cis rs7503168 0.558 rs11870472 chr17:33872649 G/A cg20932281 chr17:33905541 PEX12 0.72 5.36 0.31 1.77e-7 Plateletcrit; CESC cis rs748404 0.697 rs1814323 chr15:43563237 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.6 -7.92 -0.44 6.44e-14 Lung cancer; CESC cis rs4930103 0.782 rs10840167 chr11:2022023 G/T cg23202291 chr11:1979235 NA 0.37 5.25 0.31 3.12e-7 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg26408565 chr15:76604113 ETFA 0.39 5.98 0.34 7.3e-9 Blood metabolite levels; CESC cis rs7312774 0.867 rs10492213 chr12:107295841 A/T cg16260113 chr12:107380972 MTERFD3 -0.62 -5.82 -0.34 1.7e-8 Severe influenza A (H1N1) infection; CESC cis rs3026101 0.647 rs4790263 chr17:5307084 T/C cg24500398 chr17:5266808 RABEP1 -0.41 -5.72 -0.33 2.9e-8 Body mass index; CESC cis rs3733585 0.783 rs13148371 chr4:10032561 C/T cg02734326 chr4:10020555 SLC2A9 0.5 6.99 0.39 2.23e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.606 rs28481322 chr4:99086638 T/C cg24818145 chr4:99064322 C4orf37 0.39 5.13 0.3 5.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3820068 0.581 rs111699992 chr1:15927158 G/A cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs7188697 0.922 rs37051 chr16:58558102 C/T cg02549819 chr16:58548995 SETD6 -0.41 -5.2 -0.3 4.08e-7 QT interval; CESC cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.78 8.84 0.48 1.4e-16 Alzheimer's disease; CESC cis rs8031584 0.918 rs11639169 chr15:31255438 C/T cg08109568 chr15:31115862 NA -0.65 -8.34 -0.46 4.12e-15 Huntington's disease progression; CESC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg11764359 chr7:65958608 NA -0.92 -14.72 -0.67 2.89e-36 Aortic root size; CESC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg26335602 chr6:28129616 ZNF389 0.54 7.3 0.41 3.37e-12 Depression; CESC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg03467027 chr4:99064603 C4orf37 0.43 5.36 0.31 1.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1797081 0.967 rs780632 chr10:16861400 A/G cg23933602 chr10:16859644 RSU1 -1.1 -22.74 -0.81 3.3e-64 Platelet distribution width; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13355623 chr17:26898935 PIGS -0.46 -6.03 -0.35 5.62e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs12995491 0.902 rs6737641 chr2:88529471 A/T cg18490616 chr2:88469792 THNSL2 -0.53 -7.91 -0.44 6.92e-14 Response to metformin (IC50); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14126493 chr5:176831297 F12 -0.5 -6.74 -0.38 9.89e-11 Fibrinogen levels; CESC cis rs7937682 0.924 rs10891286 chr11:111532691 C/G cg09085632 chr11:111637200 PPP2R1B -0.99 -16.33 -0.71 5.97e-42 Primary sclerosing cholangitis; CESC cis rs3733585 0.699 rs4473653 chr4:9971058 A/G cg00071950 chr4:10020882 SLC2A9 -0.71 -11.42 -0.57 7.69e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg11644478 chr21:40555479 PSMG1 -0.54 -7.27 -0.41 4.12e-12 Menarche (age at onset); CESC cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg06634786 chr22:41940651 POLR3H 0.67 6.86 0.39 4.8e-11 Vitiligo; CESC cis rs25645 0.502 rs9895948 chr17:38108363 T/C cg17467752 chr17:38218738 THRA 0.41 5.11 0.3 6.17e-7 Myeloid white cell count; CESC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC cis rs5769765 1.000 rs5770742 chr22:50270309 T/C cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs7408868 0.831 rs7249115 chr19:15280765 A/G cg14696996 chr19:15285081 NOTCH3 0.84 9.55 0.51 9.3e-19 Pulse pressure; CESC cis rs11638352 1.000 rs2615287 chr15:44415993 A/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs546131 0.928 rs546521 chr11:34824773 G/C cg06937548 chr11:34938143 PDHX;APIP 0.51 6.26 0.36 1.57e-9 Lung disease severity in cystic fibrosis; CESC cis rs367615 0.879 rs56689485 chr5:108879828 A/T cg17395555 chr5:108820864 NA 0.56 8.33 0.46 4.38e-15 Colorectal cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26383454 chr6:11104957 HERV-FRD;LOC221710 -0.66 -8.07 -0.44 2.46e-14 Gut microbiome composition (summer); CESC cis rs2282526 0.615 rs162377 chr21:44926001 A/G cg01579765 chr21:45077557 HSF2BP -0.43 -6.54 -0.37 3.09e-10 Mean corpuscular hemoglobin; CESC cis rs9462846 0.959 rs9471954 chr6:42880326 C/A cg05552183 chr6:42928497 GNMT 0.48 5.74 0.33 2.62e-8 Blood protein levels; CESC cis rs10089 1.000 rs6887847 chr5:127473807 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.8 10.9 0.56 4.08e-23 Ileal carcinoids; CESC cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs12912251 0.947 rs7177621 chr15:38999394 C/G cg01338139 chr15:38987640 C15orf53 -0.51 -5.49 -0.32 9.57e-8 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs8067354 0.645 rs9899611 chr17:57832190 A/G cg13753209 chr17:57696993 CLTC 0.65 7.92 0.44 6.54e-14 Hemoglobin concentration; CESC cis rs4566357 1.000 rs7577005 chr2:227921573 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -5.29 -0.31 2.58e-7 Coronary artery disease; CESC trans rs17508449 0.819 rs4839331 chr1:114161631 A/G cg15464363 chr22:32149800 DEPDC5 -0.68 -6.14 -0.35 3.03e-9 Leprosy; CESC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg11764359 chr7:65958608 NA 0.98 15.78 0.7 5.36e-40 Aortic root size; CESC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg01097406 chr16:89675127 NA 0.37 5.31 0.31 2.31e-7 Vitiligo; CESC cis rs561341 0.609 rs11658984 chr17:30186612 C/T cg13647721 chr17:30228624 UTP6 -0.74 -8.56 -0.47 9.61e-16 Hip circumference adjusted for BMI; CESC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.68 -0.58 1.06e-25 Alzheimer's disease; CESC cis rs28489187 0.683 rs1554597 chr1:85877098 C/T cg16011679 chr1:85725395 C1orf52 -0.42 -5.17 -0.3 4.65e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs2976388 0.556 rs4736321 chr8:143822194 C/T cg24634471 chr8:143751801 JRK -0.46 -5.06 -0.3 7.87e-7 Urinary tract infection frequency; CESC cis rs6831352 1.000 rs6831352 chr4:100063525 T/C cg12011299 chr4:100065546 ADH4 0.69 8.37 0.46 3.38e-15 Alcohol dependence; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg08205843 chr19:12848293 ASNA1 -0.39 -6.15 -0.35 2.86e-9 Vertical cup-disc ratio; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20645649 chr9:127624485 RPL35 0.48 6.04 0.35 5.24e-9 Gut microbiota (bacterial taxa); CESC cis rs2880765 0.835 rs7164106 chr15:86032590 T/C cg10818794 chr15:86012489 AKAP13 -0.35 -5.39 -0.31 1.6e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06636460 chr16:3722631 TRAP1 -0.58 -6.68 -0.38 1.39e-10 Gut microbiome composition (summer); CESC cis rs7674212 0.570 rs6841136 chr4:104103509 A/C cg16532752 chr4:104119610 CENPE -0.4 -5.5 -0.32 8.72e-8 Type 2 diabetes; CESC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.69 0.33 3.36e-8 Electroencephalogram traits; CESC cis rs17021463 0.966 rs1565062 chr4:95183000 G/A cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.69 -0.51 3.37e-19 Testicular germ cell tumor; CESC cis rs17253792 0.822 rs78615025 chr14:56168012 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg02564969 chr6:151773285 C6orf211;RMND1 0.62 8.45 0.46 1.91e-15 Menarche (age at onset); CESC cis rs6076065 0.548 rs6048740 chr20:23325047 G/A cg11657817 chr20:23433608 CST11 0.35 5.09 0.3 6.82e-7 Facial morphology (factor 15, philtrum width); CESC cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg22467129 chr15:76604101 ETFA -0.35 -5.25 -0.31 3.16e-7 Blood metabolite levels; CESC cis rs1059312 0.966 rs2291349 chr12:129284248 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -9.81 -0.52 1.42e-19 Systemic lupus erythematosus; CESC trans rs877282 0.898 rs11253347 chr10:765769 A/G cg22713356 chr15:30763199 NA 1.15 11.3 0.57 2.06e-24 Uric acid levels; CESC cis rs4689592 0.622 rs2276968 chr4:7070118 T/G cg19539972 chr4:7069911 GRPEL1 0.8 8.96 0.48 5.79e-17 Monocyte percentage of white cells; CESC cis rs7949030 0.588 rs2428549 chr11:62312394 A/G cg02375832 chr11:62437615 C11orf48 -0.36 -5.31 -0.31 2.36e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.24 0.31 3.21e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.09 0.3 6.91e-7 Colonoscopy-negative controls vs population controls; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19111712 chr11:1301065 TOLLIP -0.46 -6.29 -0.36 1.29e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2197308 0.619 rs4002730 chr12:37876400 T/C cg13010199 chr12:38710504 ALG10B 0.52 6.64 0.38 1.8e-10 Morning vs. evening chronotype; CESC cis rs6061231 0.740 rs11698650 chr20:60958374 A/T cg15674680 chr20:60982522 CABLES2 0.46 6.03 0.35 5.63e-9 Colorectal cancer; CESC cis rs2120019 0.935 rs34913788 chr15:75372617 A/C cg17294928 chr15:75287854 SCAMP5 -0.59 -6.65 -0.38 1.64e-10 Blood trace element (Zn levels); CESC cis rs7086627 0.515 rs1870147 chr10:82212541 A/T cg00277334 chr10:82204260 NA -0.88 -14.63 -0.67 6.14e-36 Post bronchodilator FEV1; CESC cis rs2180341 0.883 rs9388568 chr6:127690694 C/A cg24812749 chr6:127587940 RNF146 1.05 15.12 0.68 1.2e-37 Breast cancer; CESC cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg21573476 chr21:45109991 RRP1B -0.5 -7.42 -0.41 1.56e-12 Mean corpuscular volume; CESC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.77 11.06 0.56 1.26e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs2732480 0.577 rs2732486 chr12:48737834 G/A cg24011408 chr12:48396354 COL2A1 0.44 5.99 0.35 6.99e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7937682 0.632 rs10891297 chr11:111770150 C/T cg09085632 chr11:111637200 PPP2R1B 0.87 10.94 0.56 3.08e-23 Primary sclerosing cholangitis; CESC trans rs11148252 0.574 rs73186430 chr13:53232891 T/C cg18335740 chr13:41363409 SLC25A15 0.53 7.08 0.4 1.31e-11 Lewy body disease; CESC cis rs75477785 1.000 rs75889558 chr1:209988809 G/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs28489187 0.558 rs2474123 chr1:85827452 C/T cg16011679 chr1:85725395 C1orf52 0.43 5.12 0.3 5.93e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs921968 0.565 rs3770219 chr2:219619766 T/C cg02176678 chr2:219576539 TTLL4 -0.44 -7.67 -0.43 3.29e-13 Mean corpuscular hemoglobin concentration; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg03188948 chr7:1209495 NA 0.53 7.14 0.4 8.8e-12 Longevity;Endometriosis; CESC cis rs2439831 0.867 rs7170489 chr15:43636651 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.37 0.54 2.27e-21 Lung cancer in ever smokers; CESC cis rs34421088 0.564 rs6983129 chr8:11591136 A/C cg13293535 chr8:11597251 GATA4 -0.29 -5.61 -0.33 4.98e-8 Neuroticism; CESC cis rs6502050 0.734 rs9674631 chr17:80096525 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.48 -0.37 4.35e-10 Life satisfaction; CESC cis rs1881797 1.000 rs10158379 chr1:247686352 C/A cg18198730 chr1:247681584 NA 0.59 7.76 0.43 1.84e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs644799 0.625 rs1255175 chr11:95471186 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.45 6.03 0.35 5.6e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs8058578 1.000 rs8048448 chr16:30692208 T/C cg02466173 chr16:30829666 NA -0.41 -6.7 -0.38 1.22e-10 Multiple myeloma; CESC cis rs826838 0.651 rs1843892 chr12:38616965 A/G cg26384229 chr12:38710491 ALG10B 0.57 8.25 0.45 7.66e-15 Heart rate; CESC cis rs62012628 0.527 rs12438008 chr15:79084680 C/T cg04896959 chr15:78267971 NA -0.5 -8.56 -0.47 9.39e-16 Diastolic blood pressure; CESC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg24829409 chr8:58192753 C8orf71 -0.75 -9.91 -0.52 6.63e-20 Developmental language disorder (linguistic errors); CESC cis rs60843830 1.000 rs3791221 chr2:226933 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.86 11.73 0.58 7.08e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.31 0.31 2.29e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7264396 0.635 rs2425166 chr20:34439391 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.35 0.41 2.49e-12 Total cholesterol levels; CESC cis rs11264213 0.591 rs274728 chr1:36493420 T/C cg27506609 chr1:36549197 TEKT2 -0.76 -6.97 -0.39 2.46e-11 Schizophrenia; CESC cis rs116095464 0.558 rs7356696 chr5:284251 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.41 0.32 1.38e-7 Breast cancer; CESC cis rs7640424 0.649 rs35595234 chr3:107922116 C/T cg09227934 chr3:107805635 CD47 -0.45 -5.82 -0.34 1.66e-8 Body mass index; CESC cis rs4253772 0.614 rs11090859 chr22:46687460 T/G cg09491104 chr22:46646882 C22orf40 -0.6 -8.9 -0.48 9.11e-17 LDL cholesterol;Cholesterol, total; CESC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg09699651 chr6:150184138 LRP11 0.41 5.11 0.3 6.05e-7 Lung cancer; CESC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.88 15.11 0.68 1.29e-37 Menarche (age at onset); CESC cis rs763121 0.785 rs5757199 chr22:39040617 T/G cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC cis rs4268898 0.662 rs58971404 chr2:24403753 G/A cg06627628 chr2:24431161 ITSN2 -0.97 -9.76 -0.51 2.07e-19 Asthma; CESC cis rs10129255 0.536 rs10142951 chr14:107190574 A/G cg23076370 chr14:107095027 NA -0.65 -9.64 -0.51 4.78e-19 Kawasaki disease; CESC cis rs6060717 0.536 rs6060670 chr20:34481143 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -6.93 -0.39 3.22e-11 Hip circumference adjusted for BMI; CESC cis rs12545109 0.879 rs2576588 chr8:57381627 G/A cg09654669 chr8:57350985 NA -0.52 -6.87 -0.39 4.5e-11 Obesity-related traits; CESC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.73 0.47 2.95e-16 Menopause (age at onset); CESC cis rs11785400 1.000 rs11776301 chr8:143737142 A/G cg24634471 chr8:143751801 JRK 0.47 6.22 0.36 1.92e-9 Schizophrenia; CESC cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg02487422 chr3:49467188 NICN1 0.42 5.34 0.31 2.01e-7 Parkinson's disease; CESC cis rs2191566 0.576 rs420355 chr19:44495325 C/T cg20607764 chr19:44506953 ZNF230 0.45 5.69 0.33 3.38e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs6570726 0.935 rs386823 chr6:145841365 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.74 0.38 1e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg16743903 chr16:89593216 SPG7 -0.45 -5.85 -0.34 1.43e-8 Multiple myeloma (IgH translocation); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12427896 chr2:111880694 BCL2L11 0.52 7.19 0.4 6.56e-12 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22905859 chr1:149576021 LOC728855 -0.54 -6.6 -0.38 2.21e-10 Gut microbiome composition (summer); CESC cis rs13072744 0.530 rs12497521 chr3:72488540 C/G cg22685502 chr3:72496851 RYBP 0.24 5.25 0.31 3.12e-7 Height; CESC cis rs8114671 0.562 rs6120739 chr20:33405227 A/G cg08999081 chr20:33150536 PIGU 0.39 5.53 0.32 7.84e-8 Height; CESC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg18765753 chr7:1198926 ZFAND2A -0.45 -6.56 -0.37 2.78e-10 Longevity;Endometriosis; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg20566420 chr12:122327043 PSMD9 0.5 6.38 0.36 7.67e-10 Obesity-related traits; CESC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg20307385 chr11:47447363 PSMC3 0.69 8.97 0.48 5.36e-17 Subjective well-being; CESC cis rs11112613 0.653 rs941101 chr12:105937098 T/G cg03607813 chr12:105948248 NA 0.59 6.38 0.37 7.72e-10 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs1707322 1.000 rs11211190 chr1:46266255 C/T cg03146154 chr1:46216737 IPP 0.73 10.13 0.53 1.3e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg24399712 chr22:39784796 NA -0.84 -11.79 -0.59 4.45e-26 Intelligence (multi-trait analysis); CESC cis rs2228479 0.850 rs12596934 chr16:89841605 T/G cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg04267008 chr7:1944627 MAD1L1 -0.61 -7.5 -0.42 9.64e-13 Bipolar disorder and schizophrenia; CESC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg07414643 chr4:187882934 NA 0.54 7.39 0.41 1.87e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg05347473 chr6:146136440 FBXO30 0.56 7.08 0.4 1.27e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs11997175 0.574 rs4733453 chr8:33650745 A/G ch.8.33884649F chr8:33765107 NA 0.64 8.25 0.45 7.24e-15 Body mass index; CESC cis rs11690935 0.885 rs7602037 chr2:172817794 G/A cg13550731 chr2:172543902 DYNC1I2 -0.82 -12.29 -0.6 8.83e-28 Schizophrenia; CESC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg11764359 chr7:65958608 NA -0.68 -8.81 -0.48 1.68e-16 Aortic root size; CESC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg04166393 chr7:2884313 GNA12 -0.57 -7.34 -0.41 2.62e-12 Height; CESC cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg17414380 chr19:19431394 KIAA0892;SF4 0.48 6.13 0.35 3.25e-9 Tonsillectomy; CESC cis rs7726839 0.540 rs72705030 chr5:645562 C/T cg16447950 chr5:562315 NA -0.6 -6.44 -0.37 5.45e-10 Obesity-related traits; CESC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg05564831 chr3:52568323 NT5DC2 0.47 7.43 0.42 1.46e-12 Bipolar disorder; CESC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg12718519 chr1:2058417 PRKCZ -0.25 -5.34 -0.31 1.99e-7 Height; CESC cis rs7605827 0.930 rs6431711 chr2:15683930 G/T cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC trans rs11039798 0.582 rs60764175 chr11:48775856 T/G cg15704280 chr7:45808275 SEPT13 0.66 6.63 0.38 1.89e-10 Axial length; CESC cis rs2635047 1.000 rs2684826 chr18:44679147 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 6.42 0.37 6.4e-10 Educational attainment; CESC cis rs3768617 0.510 rs10797849 chr1:183088988 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.37 0.63 1.66e-31 Fuchs's corneal dystrophy; CESC cis rs1843834 1.000 rs1565072 chr2:225545245 C/T cg22455342 chr2:225449267 CUL3 -0.51 -6.44 -0.37 5.71e-10 IgE levels in asthmatics (D.p. specific); CESC cis rs9549367 0.664 rs9549689 chr13:113848387 G/A cg18105134 chr13:113819100 PROZ -0.69 -8.17 -0.45 1.31e-14 Platelet distribution width; CESC cis rs67478160 0.634 rs941475 chr14:104240618 A/C cg08213375 chr14:104286397 PPP1R13B 0.47 9.13 0.49 1.81e-17 Schizophrenia; CESC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.78 0.43 1.58e-13 Prudent dietary pattern; CESC cis rs7412746 0.658 rs10888397 chr1:150886752 A/G cg04414720 chr1:150670196 GOLPH3L -0.46 -6.11 -0.35 3.54e-9 Melanoma; CESC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg02461776 chr11:598696 PHRF1 0.46 5.06 0.3 7.91e-7 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.524 rs6485786 chr11:47837408 G/C cg18512352 chr11:47633146 NA 0.35 5.33 0.31 2.05e-7 Subjective well-being; CESC cis rs11719291 0.833 rs13074318 chr3:48816725 C/T cg00383909 chr3:49044727 WDR6 0.9 6.23 0.36 1.82e-9 Cognitive function; CESC cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.4 -6.51 -0.37 3.73e-10 Hemoglobin concentration; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05863534 chr17:34948351 DHRS11 -0.48 -6.05 -0.35 4.94e-9 Ulcerative colitis; CESC cis rs910316 1.000 rs12879542 chr14:75507525 C/T cg11812906 chr14:75593930 NEK9 0.89 14.59 0.67 8.27e-36 Height; CESC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC cis rs7809799 1.000 rs75599274 chr7:98781259 A/C cg05967295 chr7:98741636 SMURF1 0.88 5.54 0.32 7.27e-8 Ulcerative colitis; CESC trans rs853679 0.607 rs35902873 chr6:28058949 G/C cg06606381 chr12:133084897 FBRSL1 -1.08 -7.66 -0.43 3.42e-13 Depression; CESC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg25036284 chr2:26402008 FAM59B -0.6 -6.93 -0.39 3.26e-11 Gut microbiome composition (summer); CESC cis rs7267979 0.966 rs6050611 chr20:25414419 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.8 16.14 0.7 2.87e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs8002861 0.905 rs12874590 chr13:44433363 C/T cg14210620 chr13:44453864 C13orf31;CCDC122 -0.39 -5.17 -0.3 4.69e-7 Leprosy; CESC cis rs34779708 0.733 rs16935948 chr10:35549748 C/G cg04310649 chr10:35416472 CREM -0.49 -5.28 -0.31 2.69e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 13.91 0.65 2.12e-33 Platelet count; CESC cis rs2836974 0.897 rs2776308 chr21:40715175 A/G cg17971929 chr21:40555470 PSMG1 0.92 12.36 0.6 5.24e-28 Cognitive function; CESC cis rs4664304 0.629 rs3828324 chr2:160834991 C/T cg03641300 chr2:160917029 PLA2R1 0.44 6.06 0.35 4.56e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs80282103 0.618 rs1079389 chr10:1161980 A/G cg08668510 chr10:1095578 IDI1 0.72 5.84 0.34 1.55e-8 Glomerular filtration rate (creatinine); CESC cis rs72781680 0.898 rs718139 chr2:23975911 G/A cg08917208 chr2:24149416 ATAD2B 1.13 10.19 0.53 8.58e-21 Lymphocyte counts; CESC cis rs2197308 0.740 rs11182967 chr12:37935140 A/C cg26384229 chr12:38710491 ALG10B 0.75 11.19 0.57 4.49e-24 Morning vs. evening chronotype; CESC cis rs1577917 0.958 rs884842 chr6:86680397 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -5.67 -0.33 3.66e-8 Response to antipsychotic treatment; CESC cis rs10791323 0.569 rs2282601 chr11:133712594 C/G cg06766960 chr11:133703094 NA -0.38 -5.41 -0.32 1.42e-7 Childhood ear infection; CESC cis rs2790457 0.792 rs1265830 chr10:28912223 A/G cg04045419 chr10:28823091 WAC 0.45 5.34 0.31 1.97e-7 Multiple myeloma; CESC cis rs7208859 0.623 rs426434 chr17:28925353 C/T cg19761014 chr17:28927070 LRRC37B2 0.69 5.92 0.34 1.02e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3540 0.553 rs12592611 chr15:91004093 C/T cg22089800 chr15:90895588 ZNF774 0.66 8.93 0.48 7.21e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs965513 1.000 rs7864322 chr9:100548934 C/T cg13688889 chr9:100608707 NA -0.6 -8.59 -0.47 7.47e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs9929218 0.748 rs34592833 chr16:68739125 G/A cg02972257 chr16:68554789 NA 0.55 6.08 0.35 4.14e-9 Colorectal cancer; CESC cis rs3820928 0.605 rs7560867 chr2:227780945 C/A cg11843606 chr2:227700838 RHBDD1 -0.57 -8.02 -0.44 3.34e-14 Pulmonary function; CESC cis rs2901656 0.677 rs1063412 chr1:172410967 G/A cg03748243 chr1:172413542 C1orf105;PIGC 0.54 8.29 0.45 5.76e-15 Red cell distribution width;Platelet distribution width; CESC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg24399712 chr22:39784796 NA -0.82 -9.31 -0.5 5.22e-18 IgG glycosylation; CESC cis rs3780486 0.846 rs10971438 chr9:33180308 A/G cg13443165 chr9:33130375 B4GALT1 0.4 5.29 0.31 2.59e-7 IgG glycosylation; CESC cis rs2742417 0.603 rs2673075 chr3:45778288 C/A cg04837898 chr3:45731254 SACM1L -0.46 -5.99 -0.35 6.85e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg06582575 chr6:163149167 PACRG;PARK2 1.02 9.29 0.5 5.65e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3806843 0.648 rs702399 chr5:140024432 C/T cg16179182 chr5:140090404 VTRNA1-1 0.41 5.24 0.31 3.21e-7 Depressive symptoms (multi-trait analysis); CESC cis rs523522 0.962 rs2393590 chr12:120913900 G/A cg12219531 chr12:120966889 COQ5 0.7 9.25 0.49 7.88e-18 High light scatter reticulocyte count; CESC cis rs7772486 0.875 rs863820 chr6:146347402 C/T cg23711669 chr6:146136114 FBXO30 -0.84 -12.23 -0.6 1.41e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs7584330 0.955 rs7581882 chr2:238390745 T/C cg14458575 chr2:238380390 NA 0.65 9.1 0.49 2.28e-17 Prostate cancer; CESC cis rs2404602 0.692 rs55729975 chr15:76803226 G/A cg22467129 chr15:76604101 ETFA -0.35 -5.22 -0.31 3.65e-7 Blood metabolite levels; CESC cis rs2072499 0.778 rs41265025 chr1:156163906 C/T cg25208724 chr1:156163844 SLC25A44 0.97 12.53 0.61 1.39e-28 Testicular germ cell tumor; CESC cis rs12541635 0.966 rs6469023 chr8:106989558 T/C cg10147462 chr8:107024639 NA 0.41 5.62 0.33 4.93e-8 Age of smoking initiation; CESC cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg08564027 chr20:61660810 NA 0.9 15.44 0.69 8.75e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs7818688 0.653 rs11776687 chr8:95836307 T/C cg16049864 chr8:95962084 TP53INP1 0.54 5.7 0.33 3.15e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7116495 0.609 rs17161751 chr11:71688347 G/A cg10381502 chr11:71823885 C11orf51 1.16 7.27 0.41 4.06e-12 Severe influenza A (H1N1) infection; CESC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs208520 0.802 rs208516 chr6:66946119 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.86 -9.92 -0.52 6.4e-20 Exhaled nitric oxide output; CESC cis rs6541297 0.645 rs612577 chr1:230324364 A/G cg20703242 chr1:230279135 GALNT2 -0.52 -5.95 -0.34 8.44e-9 Coronary artery disease; CESC cis rs10779751 0.734 rs6701726 chr1:11126941 C/T cg08854313 chr1:11322531 MTOR 0.77 10.41 0.54 1.73e-21 Body mass index; CESC cis rs2075371 0.611 rs13235296 chr7:134019192 A/G cg20476274 chr7:133979776 SLC35B4 -0.54 -7.31 -0.41 3.08e-12 Mean platelet volume; CESC cis rs116095464 0.558 rs57335027 chr5:262907 A/G cg20965017 chr5:231967 SDHA -0.48 -5.43 -0.32 1.25e-7 Breast cancer; CESC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg21144161 chr5:423903 AHRR 0.37 5.98 0.34 7.12e-9 Cystic fibrosis severity; CESC cis rs11098499 0.604 rs2389887 chr4:120570644 T/C cg09307838 chr4:120376055 NA 0.76 9.58 0.51 7.28e-19 Corneal astigmatism; CESC cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg05283184 chr6:79620031 NA -0.44 -6.84 -0.39 5.6e-11 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12061021 chr1:95699574 RWDD3 -0.69 -7.68 -0.43 3.11e-13 Gut microbiome composition (summer); CESC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg18904891 chr8:8559673 CLDN23 0.67 7.49 0.42 1.01e-12 Obesity-related traits; CESC cis rs6967414 0.786 rs7782227 chr7:6748594 T/C cg09896999 chr7:6746977 ZNF12 -0.58 -7.08 -0.4 1.32e-11 Hematocrit;Hemoglobin concentration; CESC cis rs7267979 1.000 rs2259956 chr20:25282433 A/G cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1775715 0.870 rs1775737 chr10:32256871 T/C cg04359828 chr10:32216031 ARHGAP12 0.35 5.13 0.3 5.49e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7903847 0.642 rs9887991 chr10:99159634 T/C cg20016023 chr10:99160130 RRP12 -0.3 -5.24 -0.31 3.3e-7 Granulocyte percentage of myeloid white cells; CESC cis rs72781680 0.898 rs72780125 chr2:24000145 T/C cg20701182 chr2:24300061 SF3B14 0.78 6.7 0.38 1.22e-10 Lymphocyte counts; CESC cis rs17407555 0.909 rs73224409 chr4:10290646 G/T cg11266682 chr4:10021025 SLC2A9 -0.48 -5.81 -0.34 1.83e-8 Schizophrenia (age at onset); CESC cis rs8067545 0.750 rs35003563 chr17:19989218 G/A cg13482628 chr17:19912719 NA 0.39 5.39 0.31 1.58e-7 Schizophrenia; CESC cis rs4141404 0.818 rs6518737 chr22:31582662 A/G cg02404636 chr22:31891804 SFI1 -0.38 -5.49 -0.32 9.52e-8 Paclitaxel-induced neuropathy; CESC cis rs344364 0.511 rs1742472 chr16:1953040 A/G cg03013636 chr16:1946785 NA 0.49 6.83 0.39 5.92e-11 Glomerular filtration rate in chronic kidney disease; CESC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg09359103 chr1:154839909 KCNN3 -0.66 -12.68 -0.61 4.13e-29 Prostate cancer; CESC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.84 0.34 1.51e-8 Tonsillectomy; CESC cis rs12144309 0.608 rs1217417 chr1:114400904 C/G cg13572289 chr1:114447746 DCLRE1B;AP4B1 0.45 5.09 0.3 6.69e-7 Coronary artery disease; CESC cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3806843 0.735 rs809635 chr5:140081791 A/G cg26395211 chr5:140044315 WDR55 0.48 6.15 0.35 2.79e-9 Depressive symptoms (multi-trait analysis); CESC cis rs2014572 0.967 rs10426174 chr19:57756055 G/A cg24459738 chr19:57751996 ZNF805 -0.54 -7.78 -0.43 1.67e-13 Hyperactive-impulsive symptoms; CESC cis rs6484504 0.576 rs438578 chr11:31222579 A/G cg14844989 chr11:31128820 NA 0.4 5.58 0.32 6.07e-8 Red blood cell count; CESC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg10691866 chr7:65817282 TPST1 -0.33 -5.43 -0.32 1.3e-7 Aortic root size; CESC cis rs12586317 0.547 rs45531432 chr14:35484423 C/T cg05294307 chr14:35346193 BAZ1A -0.51 -5.48 -0.32 1.01e-7 Psoriasis; CESC cis rs965469 1.000 rs6051715 chr20:3266548 C/T cg25506879 chr20:3388711 C20orf194 -0.55 -6.0 -0.35 6.41e-9 IFN-related cytopenia; CESC cis rs3820068 0.705 rs58424111 chr1:15868470 A/C cg18192808 chr1:15853278 DNAJC16 0.46 5.63 0.33 4.49e-8 Systolic blood pressure; CESC cis rs1355223 0.583 rs2915238 chr11:34884405 C/A cg24088639 chr11:34937564 PDHX;APIP -0.41 -5.17 -0.3 4.72e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2816062 0.786 rs2816055 chr1:18898248 A/G cg18795169 chr1:18902165 NA -0.94 -18.87 -0.76 6.42e-51 Urate levels in lean individuals; CESC cis rs6582630 0.555 rs6582503 chr12:38557886 A/C cg13010199 chr12:38710504 ALG10B 0.56 7.18 0.4 7.18e-12 Drug-induced liver injury (flucloxacillin); CESC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg18099408 chr3:52552593 STAB1 0.31 5.13 0.3 5.62e-7 Bipolar disorder; CESC cis rs2066819 1.000 rs1802236 chr12:56679751 A/G cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs1620921 0.524 rs4440440 chr6:161183424 A/C cg01280913 chr6:161186852 NA -0.43 -6.41 -0.37 6.63e-10 Lipoprotein (a) - cholesterol levels; CESC cis rs7084402 0.967 rs1649026 chr10:60281400 A/G cg07615347 chr10:60278583 BICC1 -0.58 -9.28 -0.5 6.09e-18 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17687970 chr8:22462467 KIAA1967 0.58 6.65 0.38 1.63e-10 Gut microbiome composition (summer); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg23286353 chr2:97523832 ANKRD39 0.5 6.13 0.35 3.17e-9 Psoriatic arthritis; CESC cis rs11690935 1.000 rs312918 chr2:172569587 C/G cg13550731 chr2:172543902 DYNC1I2 -1.0 -16.63 -0.71 5.26e-43 Schizophrenia; CESC cis rs7937682 0.824 rs11213962 chr11:111506027 G/A cg09085632 chr11:111637200 PPP2R1B -0.99 -16.01 -0.7 8.36e-41 Primary sclerosing cholangitis; CESC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.44 7.38 0.41 2.1e-12 Personality dimensions; CESC cis rs2625529 0.689 rs8178 chr15:72114747 G/A cg16672083 chr15:72433130 SENP8 -0.53 -7.9 -0.44 7.57e-14 Red blood cell count; CESC cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2933343 0.700 rs6787833 chr3:128656184 A/G cg25356066 chr3:128598488 ACAD9 0.61 8.56 0.47 9.37e-16 IgG glycosylation; CESC cis rs10411936 0.720 rs4808513 chr19:16580498 G/C cg10248733 chr19:16607483 C19orf44;CALR3 0.53 6.62 0.38 1.96e-10 White blood cell count;Multiple sclerosis; CESC cis rs2708240 0.967 rs2247043 chr7:147580236 T/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.36 -5.99 -0.35 6.79e-9 QT interval (drug interaction); CESC cis rs763121 0.853 rs8142098 chr22:39058757 T/G cg06022373 chr22:39101656 GTPBP1 0.88 13.88 0.65 2.66e-33 Menopause (age at onset); CESC cis rs3857536 0.706 rs7749120 chr6:66889832 T/G cg07460842 chr6:66804631 NA -0.42 -5.39 -0.31 1.56e-7 Blood trace element (Cu levels); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21395147 chr1:211849137 NEK2 -0.53 -6.85 -0.39 5.12e-11 Ulcerative colitis; CESC cis rs7945705 0.934 rs1988709 chr11:8882890 A/T cg12365402 chr11:9010492 NRIP3 0.36 5.54 0.32 7.27e-8 Hemoglobin concentration; CESC cis rs901683 1.000 rs12762495 chr10:46013615 T/C cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg18225595 chr11:63971243 STIP1 -0.64 -9.02 -0.48 3.93e-17 Platelet count; CESC cis rs8077577 0.689 rs16961133 chr17:18223548 C/T cg16794390 chr17:18148240 FLII 0.4 6.34 0.36 9.98e-10 Obesity-related traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23435730 chr3:127770634 SEC61A1 0.46 5.99 0.35 6.66e-9 Gut microbiota (bacterial taxa); CESC cis rs9914988 0.943 rs7215310 chr17:27088626 G/T cg20469991 chr17:27169893 C17orf63 -0.5 -5.45 -0.32 1.13e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs4423214 0.650 rs4245442 chr11:71220909 T/C cg05163923 chr11:71159392 DHCR7 0.78 9.81 0.52 1.41e-19 Vitamin D levels; CESC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg27535305 chr1:53392650 SCP2 0.35 6.14 0.35 3.01e-9 Monocyte count; CESC cis rs12477438 0.520 rs6542870 chr2:99796638 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 15.36 0.69 1.63e-38 Chronic sinus infection; CESC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg00106254 chr7:1943704 MAD1L1 -0.5 -6.27 -0.36 1.48e-9 Bipolar disorder and schizophrenia; CESC cis rs10883723 0.773 rs11191303 chr10:104255158 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs7666738 0.830 rs2865989 chr4:99067532 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.5 0.46 1.41e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg11752832 chr7:134001865 SLC35B4 0.52 6.78 0.38 7.85e-11 Mean platelet volume; CESC cis rs3820068 0.608 rs12091644 chr1:16044945 G/A cg17385448 chr1:15911702 AGMAT 0.38 5.93 0.34 9.29e-9 Systolic blood pressure; CESC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Depression; CESC cis rs11750568 0.967 rs6879775 chr5:178515196 A/G cg10208897 chr5:178548229 ADAMTS2 -0.38 -5.19 -0.3 4.15e-7 Height; CESC cis rs2204008 0.748 rs8186658 chr12:38301461 A/C cg26384229 chr12:38710491 ALG10B 0.64 9.48 0.5 1.53e-18 Bladder cancer; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg25103766 chr1:120838445 FAM72B -0.46 -6.16 -0.35 2.73e-9 Recombination measurement; CESC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.08 -0.3 7.13e-7 Bipolar disorder; CESC cis rs644799 0.710 rs11021311 chr11:95505227 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.61 0.58 1.86e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3820068 0.705 rs4646085 chr1:15825411 A/T cg17385448 chr1:15911702 AGMAT 0.38 5.99 0.35 6.96e-9 Systolic blood pressure; CESC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg18016565 chr1:150552671 MCL1 0.33 5.13 0.3 5.67e-7 Tonsillectomy; CESC cis rs951366 0.677 rs1775140 chr1:205672107 C/A cg14159672 chr1:205819179 PM20D1 0.76 10.94 0.56 3.03e-23 Menarche (age at onset); CESC cis rs3820928 0.874 rs10207404 chr2:227794420 T/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.73 -0.33 2.73e-8 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16581532 chr11:66445312 RBM4B 0.58 6.26 0.36 1.57e-9 Gut microbiome composition (summer); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg17436476 chr1:62120002 NA 0.37 6.09 0.35 4.05e-9 Breast cancer; CESC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg18225595 chr11:63971243 STIP1 0.52 5.13 0.3 5.55e-7 Mean platelet volume; CESC trans rs921968 0.541 rs667251 chr2:219384384 C/G cg15547669 chr20:2781122 CPXM1 0.36 6.01 0.35 6.14e-9 Mean corpuscular hemoglobin concentration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26401822 chr12:123459832 ABCB9;OGFOD2 -0.55 -7.19 -0.4 6.68e-12 Fibrinogen levels; CESC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg09165964 chr15:75287851 SCAMP5 0.49 6.49 0.37 4.14e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs2380220 1.000 rs9632496 chr6:95976450 C/G cg15832292 chr6:96025679 MANEA 0.66 6.14 0.35 3.01e-9 Behavioural disinhibition (generation interaction); CESC cis rs7666738 0.688 rs35739409 chr4:98576934 C/T cg17366294 chr4:99064904 C4orf37 0.5 5.25 0.31 3.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.56 0.37 2.87e-10 Life satisfaction; CESC cis rs1144333 1.000 rs5745327 chr1:76270040 A/T cg22875332 chr1:76189707 ACADM -0.56 -5.8 -0.34 1.93e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs2247341 1.000 rs13124276 chr4:1700368 C/T cg07465881 chr4:1713556 SLBP -0.54 -6.94 -0.39 2.99e-11 Hip circumference adjusted for BMI;Height; CESC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg15664640 chr17:80829946 TBCD -0.63 -8.99 -0.48 4.82e-17 Breast cancer; CESC cis rs6540559 0.546 rs735693 chr1:210033988 A/C cg21951975 chr1:209979733 IRF6 0.55 6.46 0.37 5.11e-10 Cleft lip with or without cleft palate; CESC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg12463550 chr7:65579703 CRCP 0.49 6.35 0.36 9.31e-10 Aortic root size; CESC cis rs5750830 0.645 rs756640 chr22:39779300 G/A cg02038168 chr22:39784481 NA -0.56 -7.62 -0.42 4.59e-13 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs634534 0.561 rs655744 chr11:65776585 G/T cg02202077 chr11:65769826 EIF1AD;BANF1 -0.46 -6.24 -0.36 1.76e-9 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs6484504 0.576 rs158146 chr11:31210433 G/A cg14844989 chr11:31128820 NA -0.37 -5.38 -0.31 1.65e-7 Red blood cell count; CESC trans rs7307889 0.793 rs12320367 chr12:6012462 G/A cg18407955 chr7:158110685 PTPRN2 -0.77 -6.94 -0.39 2.96e-11 Obesity-related traits; CESC cis rs838147 0.508 rs507766 chr19:49208543 T/C cg21064579 chr19:49206444 FUT2 0.44 6.15 0.35 2.83e-9 Dietary macronutrient intake; CESC cis rs11676348 0.846 rs7594532 chr2:219008000 T/C cg00012203 chr2:219082015 ARPC2 -0.58 -7.46 -0.42 1.21e-12 Ulcerative colitis; CESC cis rs6429082 0.608 rs903348 chr1:235571343 C/T cg26050004 chr1:235667680 B3GALNT2 -0.54 -6.77 -0.38 8.47e-11 Adiposity; CESC cis rs67478160 0.643 rs8005594 chr14:104279889 T/C cg08213375 chr14:104286397 PPP1R13B 0.54 10.64 0.55 2.94e-22 Schizophrenia; CESC cis rs12586317 0.620 rs79832710 chr14:35547434 G/T cg05294307 chr14:35346193 BAZ1A -0.5 -5.32 -0.31 2.2e-7 Psoriasis; CESC cis rs2637266 0.739 rs727902 chr10:78436425 A/C cg18941641 chr10:78392320 NA 0.4 7.32 0.41 2.99e-12 Pulmonary function; CESC cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08674093 chr3:182697846 DCUN1D1 -0.66 -7.57 -0.42 6.39e-13 Gut microbiome composition (summer); CESC cis rs7044106 0.791 rs12554440 chr9:123485333 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.88 14.11 0.66 4.17e-34 Hip circumference adjusted for BMI; CESC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg25985355 chr7:65971099 NA 0.33 5.39 0.31 1.53e-7 Aortic root size; CESC cis rs3749237 0.595 rs11720264 chr3:49580347 C/T cg03060546 chr3:49711283 APEH 0.75 11.44 0.58 6.67e-25 Resting heart rate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13318091 chr8:27145541 TRIM35 0.53 7.32 0.41 2.91e-12 Fibrinogen levels; CESC trans rs61931739 0.517 rs2636073 chr12:34063049 C/T cg26384229 chr12:38710491 ALG10B 0.52 6.96 0.39 2.64e-11 Morning vs. evening chronotype; CESC cis rs4588572 0.643 rs10043115 chr5:77692019 T/C cg11547950 chr5:77652471 NA 0.46 5.98 0.34 7.29e-9 Triglycerides; CESC trans rs61931739 0.782 rs451940 chr12:34196005 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.59 0.38 2.37e-10 Morning vs. evening chronotype; CESC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg17372223 chr3:52568218 NT5DC2 0.39 5.49 0.32 9.29e-8 Bipolar disorder; CESC cis rs34779708 0.966 rs11599606 chr10:35406626 G/A cg04310649 chr10:35416472 CREM -0.54 -6.45 -0.37 5.33e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg23758822 chr17:41437982 NA 1.0 17.42 0.73 7.78e-46 Menopause (age at onset); CESC cis rs9611565 0.694 rs202616 chr22:41822221 C/G cg06481639 chr22:41940642 POLR3H 0.64 6.41 0.37 6.73e-10 Vitiligo; CESC cis rs4835473 0.897 rs7682204 chr4:144887459 T/G cg25736465 chr4:144833511 NA 0.41 6.43 0.37 6.01e-10 Immature fraction of reticulocytes; CESC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg18337363 chr3:52569053 NT5DC2 0.3 5.5 0.32 8.98e-8 Bipolar disorder; CESC cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg20307385 chr11:47447363 PSMC3 -0.62 -7.65 -0.43 3.64e-13 Subjective well-being; CESC cis rs6942756 0.806 rs2718093 chr7:128939582 G/A cg02491457 chr7:128862824 NA -0.63 -9.0 -0.48 4.48e-17 White matter hyperintensity burden; CESC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg17911788 chr17:44343683 NA 0.43 6.71 0.38 1.16e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs208520 0.690 rs866452 chr6:66849936 A/T cg07460842 chr6:66804631 NA -0.92 -12.59 -0.61 8.53e-29 Exhaled nitric oxide output; CESC cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg00745463 chr17:30367425 LRRC37B -0.81 -7.35 -0.41 2.5e-12 Hip circumference adjusted for BMI; CESC cis rs826838 0.967 rs2892410 chr12:38990282 A/G cg26384229 chr12:38710491 ALG10B -0.83 -14.62 -0.67 6.94e-36 Heart rate; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19029301 chr20:30795553 POFUT1;PLAGL2 -0.53 -7.28 -0.41 3.76e-12 Asthma; CESC cis rs9467711 0.606 rs9379859 chr6:26369549 C/T cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC cis rs4237845 0.537 rs59401446 chr12:58259564 G/A cg02175503 chr12:58329896 NA 0.43 5.03 0.3 8.94e-7 Intelligence (multi-trait analysis); CESC cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg00750074 chr16:89608354 SPG7 0.36 5.2 0.3 4.07e-7 Multiple myeloma (IgH translocation); CESC cis rs7086627 0.515 rs2125040 chr10:82208422 G/C cg03267442 chr10:82210566 NA -0.34 -5.6 -0.33 5.31e-8 Post bronchodilator FEV1; CESC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg18876405 chr7:65276391 NA -0.5 -6.67 -0.38 1.46e-10 Aortic root size; CESC cis rs12545109 0.837 rs1437277 chr8:57356734 T/C cg09654669 chr8:57350985 NA -0.6 -6.98 -0.39 2.44e-11 Obesity-related traits; CESC cis rs7659604 0.540 rs28672860 chr4:122705051 G/A cg19748678 chr4:122722346 EXOSC9 -0.42 -5.28 -0.31 2.64e-7 Type 2 diabetes; CESC cis rs4242434 0.819 rs55776566 chr8:22469492 T/C cg03733263 chr8:22462867 KIAA1967 0.87 14.78 0.67 1.87e-36 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg10523679 chr1:76189770 ACADM 0.69 6.69 0.38 1.32e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg08859206 chr1:53392774 SCP2 0.48 6.33 0.36 1.06e-9 Monocyte count; CESC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg25767906 chr1:53392781 SCP2 -0.45 -5.76 -0.33 2.27e-8 Monocyte count; CESC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg05872129 chr22:39784769 NA -0.81 -9.9 -0.52 7.26e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg18350739 chr11:68623251 NA -0.44 -6.49 -0.37 4.16e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg21361702 chr7:150065534 REPIN1 0.49 5.41 0.32 1.43e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg18904891 chr8:8559673 CLDN23 0.7 7.75 0.43 1.95e-13 Obesity-related traits; CESC cis rs9388451 0.505 rs9372828 chr6:126175185 A/T cg05901451 chr6:126070800 HEY2 -0.42 -5.71 -0.33 3.01e-8 Brugada syndrome; CESC cis rs3818285 0.679 rs552419 chr10:111630883 G/T cg00817464 chr10:111662876 XPNPEP1 0.45 6.99 0.39 2.19e-11 Superior crus of antihelix expression; CESC cis rs763121 0.886 rs1013339 chr22:38974680 C/T cg06022373 chr22:39101656 GTPBP1 0.88 14.49 0.66 2.01e-35 Menopause (age at onset); CESC cis rs8177179 1.000 rs8177179 chr3:133463457 G/A cg16262614 chr3:133464971 TF 0.38 7.59 0.42 5.42e-13 Iron status biomarkers (transferrin levels); CESC cis rs4727027 0.870 rs62507509 chr7:148795522 C/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.84 -0.39 5.49e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09320337 chr8:146033038 ZNF517 0.48 6.36 0.36 8.59e-10 Fibrinogen levels; CESC cis rs6061231 0.556 rs6121571 chr20:60977323 T/G cg24112000 chr20:60950667 NA -0.5 -7.12 -0.4 9.97e-12 Colorectal cancer; CESC cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg05340658 chr4:99064831 C4orf37 0.79 12.28 0.6 9.45e-28 Colonoscopy-negative controls vs population controls; CESC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg18446336 chr7:2847575 GNA12 0.38 5.85 0.34 1.48e-8 Height; CESC trans rs11098499 0.645 rs78422072 chr4:120281042 C/T cg25214090 chr10:38739885 LOC399744 0.67 9.02 0.48 3.81e-17 Corneal astigmatism; CESC cis rs7481584 0.924 rs12805661 chr11:3020740 C/T cg25174290 chr11:3078921 CARS -0.45 -5.5 -0.32 8.85e-8 Calcium levels; CESC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg04267008 chr7:1944627 MAD1L1 -0.5 -6.05 -0.35 4.86e-9 Bipolar disorder and schizophrenia; CESC cis rs4523957 0.620 rs58187837 chr17:2073272 G/C cg16513277 chr17:2031491 SMG6 -0.77 -11.18 -0.57 4.99e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7267979 1.000 rs6050609 chr20:25411751 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.11 -0.74 3.06e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 12.04 0.59 6.51e-27 Platelet count; CESC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02795432 chr2:204193336 ABI2 0.64 7.38 0.41 2.01e-12 Gut microbiome composition (summer); CESC cis rs2228479 0.867 rs34604714 chr16:89948985 A/G cg04013166 chr16:89971882 TCF25 0.77 7.14 0.4 8.86e-12 Skin colour saturation; CESC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 9.53 0.51 1.04e-18 Platelet count; CESC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.51 -0.37 3.7e-10 Bipolar disorder; CESC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.38 5.08 0.3 7.13e-7 Menopause (age at onset); CESC cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg13902645 chr11:5959945 NA -0.68 -7.8 -0.43 1.45e-13 DNA methylation (variation); CESC cis rs7116495 0.609 rs4477459 chr11:71720616 T/C cg10381502 chr11:71823885 C11orf51 -1.16 -7.71 -0.43 2.62e-13 Severe influenza A (H1N1) infection; CESC cis rs8180040 1.000 rs11130127 chr3:47398793 C/G cg27129171 chr3:47204927 SETD2 -0.68 -10.46 -0.54 1.12e-21 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00852613 chr13:50159829 RCBTB1 0.62 7.65 0.43 3.82e-13 Gut microbiome composition (summer); CESC cis rs9488822 0.676 rs1338667 chr6:116323910 T/A cg05304507 chr6:116381966 FRK 0.26 6.56 0.37 2.82e-10 Cholesterol, total;LDL cholesterol; CESC cis rs2519796 0.531 rs2789850 chr9:136807655 T/C cg13751417 chr9:136814406 VAV2 -0.4 -5.2 -0.3 4.02e-7 Hematocrit;Hemoglobin concentration; CESC cis rs9905704 0.681 rs1468540 chr17:56561942 C/T cg12560992 chr17:57184187 TRIM37 -0.62 -5.6 -0.33 5.46e-8 Testicular germ cell tumor; CESC cis rs2745967 0.650 rs11576704 chr1:208117587 G/C cg09788693 chr1:208063733 CD34 0.31 5.07 0.3 7.55e-7 Resting heart rate; CESC cis rs5758511 0.689 rs17002947 chr22:42688532 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.49 -6.76 -0.38 8.76e-11 Birth weight; CESC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg03709012 chr19:19516395 GATAD2A 0.95 13.87 0.65 2.84e-33 Tonsillectomy; CESC cis rs1986734 0.576 rs12503749 chr4:77418383 T/C cg20311846 chr4:77356250 SHROOM3 -0.26 -5.28 -0.31 2.63e-7 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC trans rs11098499 0.754 rs7672778 chr4:120248585 A/G cg25214090 chr10:38739885 LOC399744 0.62 8.71 0.47 3.41e-16 Corneal astigmatism; CESC cis rs10791097 0.694 rs2155752 chr11:130755998 C/T cg12179176 chr11:130786555 SNX19 0.66 10.36 0.54 2.45e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2952156 0.684 rs931992 chr17:37821435 G/T cg00129232 chr17:37814104 STARD3 -0.82 -12.28 -0.6 9.5e-28 Asthma; CESC cis rs9487051 0.676 rs7753705 chr6:109593302 A/C cg01475377 chr6:109611718 NA -0.44 -6.99 -0.39 2.19e-11 Reticulocyte fraction of red cells; CESC cis rs1728785 1.000 rs3203684 chr16:68600440 C/T cg02972257 chr16:68554789 NA 0.58 6.67 0.38 1.49e-10 Ulcerative colitis; CESC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg23048001 chr7:2026167 MAD1L1 0.47 6.03 0.35 5.47e-9 Bipolar disorder and schizophrenia; CESC trans rs61931739 0.534 rs1490109 chr12:34064077 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.25 0.41 4.71e-12 Morning vs. evening chronotype; CESC cis rs1322639 0.657 rs12203887 chr6:169572252 C/T cg03254818 chr6:169586852 NA 0.55 5.83 0.34 1.61e-8 Pulse pressure; CESC cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg19717773 chr7:2847554 GNA12 -0.5 -7.94 -0.44 5.89e-14 Height; CESC cis rs4481887 0.708 rs28729425 chr1:248563027 T/C cg26353448 chr1:248524236 OR2T4 -0.37 -5.18 -0.3 4.42e-7 Common traits (Other); CESC cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -5.13 -0.3 5.49e-7 Personality dimensions; CESC cis rs7551222 0.721 rs4951080 chr1:204533284 A/G cg20240347 chr1:204465584 NA -0.28 -5.66 -0.33 4.03e-8 Schizophrenia; CESC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg11843238 chr5:131593191 PDLIM4 0.37 5.36 0.31 1.84e-7 Breast cancer; CESC cis rs80130819 0.688 rs7305418 chr12:48586112 A/G cg07561017 chr12:48398056 COL2A1 0.39 5.19 0.3 4.22e-7 Prostate cancer; CESC cis rs9611565 0.649 rs5758344 chr22:41817685 G/A cg06481639 chr22:41940642 POLR3H 0.64 6.41 0.37 6.77e-10 Vitiligo; CESC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg17971929 chr21:40555470 PSMG1 1.07 16.37 0.71 4.27e-42 Cognitive function; CESC cis rs7084402 0.967 rs7097576 chr10:60277055 G/A cg07615347 chr10:60278583 BICC1 -0.6 -9.67 -0.51 3.99e-19 Refractive error; CESC cis rs9303401 0.659 rs12946397 chr17:56769979 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC cis rs68170813 0.605 rs2299428 chr7:107134384 A/G cg02696742 chr7:106810147 HBP1 -0.55 -5.09 -0.3 6.65e-7 Coronary artery disease; CESC cis rs6570726 0.935 rs424263 chr6:145840073 A/C cg05347473 chr6:146136440 FBXO30 0.49 6.74 0.38 1e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2251381 0.515 rs2832299 chr21:30749237 G/C cg24692254 chr21:30365293 RNF160 0.47 5.89 0.34 1.14e-8 Selective IgA deficiency; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06689688 chr16:46918233 GPT2 -0.45 -6.23 -0.36 1.84e-9 Fibrinogen levels; CESC trans rs2658782 0.826 rs2925355 chr11:93090887 T/C cg03479527 chr8:145637966 SLC39A4 -0.41 -6.0 -0.35 6.35e-9 Pulmonary function decline; CESC cis rs9287719 0.934 rs10181806 chr2:10741141 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs1355223 0.902 rs865070 chr11:34742497 A/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.33 -0.36 1.05e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs4319547 0.956 rs7316149 chr12:123063912 G/A cg23029597 chr12:123009494 RSRC2 -0.5 -5.55 -0.32 7.09e-8 Body mass index; CESC cis rs67478160 0.643 rs8003653 chr14:104298836 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.48 0.54 9.85e-22 Schizophrenia; CESC cis rs7210086 0.808 rs8073267 chr17:70639514 G/C cg04206342 chr17:70636940 NA -0.31 -5.69 -0.33 3.31e-8 Ulcerative colitis; CESC cis rs60154123 0.772 rs815358 chr1:210430437 A/G cg21951975 chr1:209979733 IRF6 0.46 5.93 0.34 9.5e-9 Coronary artery disease; CESC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02008169 chr16:31885058 ZNF267 -0.53 -6.18 -0.35 2.41e-9 Response to antipsychotic treatment; CESC cis rs1707322 0.964 rs6697830 chr1:46290477 C/A cg06784218 chr1:46089804 CCDC17 0.32 5.47 0.32 1.04e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2066819 1.000 rs2291361 chr12:56717805 G/A cg26804944 chr12:56660921 COQ10A -0.85 -5.14 -0.3 5.39e-7 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16968475 chr7:2027283 MAD1L1 -0.6 -6.77 -0.38 8.39e-11 Gut microbiome composition (summer); CESC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg18876405 chr7:65276391 NA -0.55 -6.01 -0.35 6.19e-9 Aortic root size; CESC cis rs4730250 0.707 rs257381 chr7:106803963 T/C cg02696742 chr7:106810147 HBP1 -0.54 -5.16 -0.3 4.82e-7 Osteoarthritis; CESC cis rs6977660 0.507 rs4721822 chr7:19771693 T/C cg07541023 chr7:19748670 TWISTNB 0.8 7.31 0.41 3.17e-12 Thyroid stimulating hormone; CESC cis rs400736 0.729 rs9434948 chr1:8004963 A/C cg25007680 chr1:8021821 PARK7 -0.56 -7.72 -0.43 2.44e-13 Response to antidepressants and depression; CESC cis rs9486719 0.947 rs11757102 chr6:96885073 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs556990 0.760 rs3024739 chr13:113819948 G/A cg18105134 chr13:113819100 PROZ -0.66 -7.47 -0.42 1.19e-12 Blood protein levels; CESC cis rs16895831 0.519 rs61298049 chr6:42540394 T/G cg10605015 chr6:42532144 UBR2 -0.52 -5.8 -0.34 1.89e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg11494091 chr17:61959527 GH2 0.73 12.56 0.61 1.04e-28 Prudent dietary pattern; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg22708233 chr11:47198576 ARFGAP2 0.39 6.12 0.35 3.33e-9 Vertical cup-disc ratio; CESC cis rs9467711 0.606 rs1978 chr6:26377573 A/T cg14345882 chr6:26364793 BTN3A2 0.62 6.47 0.37 4.76e-10 Autism spectrum disorder or schizophrenia; CESC cis rs611744 0.870 rs635941 chr8:109235457 G/A cg21045802 chr8:109455806 TTC35 0.48 5.86 0.34 1.36e-8 Dupuytren's disease; CESC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg11764359 chr7:65958608 NA -0.78 -11.22 -0.57 3.73e-24 Aortic root size; CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg04234412 chr22:24373322 LOC391322 -0.61 -8.98 -0.48 5.12e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs941873 0.869 rs7917610 chr10:81117237 T/C cg08514558 chr10:81106712 PPIF 0.36 6.22 0.36 1.94e-9 Height; CESC cis rs897080 0.515 rs1085486 chr2:44617324 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.49 0.32 9.56e-8 Height; CESC cis rs910316 1.000 rs3742773 chr14:75579643 A/G cg11812906 chr14:75593930 NEK9 0.89 15.4 0.69 1.16e-38 Height; CESC cis rs10208940 0.920 rs35878577 chr2:68737456 C/T cg12452813 chr2:68675892 NA 0.51 5.08 0.3 7.01e-7 Urate levels in lean individuals; CESC cis rs2279817 0.863 rs6586569 chr1:18027377 T/C cg21791023 chr1:18019539 ARHGEF10L 0.55 8.09 0.45 2.11e-14 Neuroticism; CESC trans rs6934970 0.860 rs9374354 chr6:112986614 C/T cg05146922 chr2:10634174 NA 0.39 6.76 0.38 8.97e-11 Bipolar disorder (body mass index interaction); CESC cis rs12534701 0.904 rs3817518 chr7:154672809 C/T cg24255201 chr7:154684926 DPP6 0.46 6.12 0.35 3.35e-9 Colorectal cancer (diet interaction); CESC cis rs727505 0.954 rs2239532 chr7:124405676 A/C cg23710748 chr7:124431027 NA -0.46 -7.31 -0.41 3.1e-12 Lewy body disease; CESC cis rs5753037 0.653 rs131272 chr22:30153655 A/G cg01021169 chr22:30184971 ASCC2 -0.44 -6.23 -0.36 1.83e-9 Type 1 diabetes; CESC cis rs3096299 0.719 rs2965818 chr16:89510494 A/G cg02034447 chr16:89574710 SPG7 0.46 5.83 0.34 1.64e-8 Multiple myeloma (IgH translocation); CESC cis rs524281 0.773 rs2155198 chr11:66014300 C/T cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.38e-7 Electroencephalogram traits; CESC cis rs116095464 0.510 rs73016876 chr5:244475 T/C cg20965017 chr5:231967 SDHA -0.47 -5.27 -0.31 2.84e-7 Breast cancer; CESC cis rs965469 0.779 rs6051785 chr20:3339199 C/T cg25506879 chr20:3388711 C20orf194 -0.47 -5.07 -0.3 7.62e-7 IFN-related cytopenia; CESC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 -1.13 -12.09 -0.6 4.19e-27 Platelet count; CESC cis rs1153858 1.000 rs60476496 chr15:45713801 C/T cg21132104 chr15:45694354 SPATA5L1 0.86 11.69 0.58 9.6e-26 Homoarginine levels; CESC cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.14 -0.3 5.24e-7 Obesity-related traits; CESC cis rs8028182 0.549 rs4886696 chr15:75664570 A/T cg20655648 chr15:75932815 IMP3 -0.46 -5.79 -0.34 2.01e-8 Sudden cardiac arrest; CESC cis rs12971120 0.947 rs8083001 chr18:72165058 A/G cg25817165 chr18:72167213 CNDP2 -0.53 -7.49 -0.42 1.05e-12 Refractive error; CESC cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg03538708 chr1:25844672 NA -0.42 -6.28 -0.36 1.4e-9 Erythrocyte sedimentation rate; CESC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.61 0.81 8.52e-64 Prudent dietary pattern; CESC cis rs7267979 0.753 rs404148 chr20:25447931 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.72 12.09 0.6 4.21e-27 Liver enzyme levels (alkaline phosphatase); CESC cis rs12748961 0.557 rs823127 chr1:205713139 G/A cg14893161 chr1:205819251 PM20D1 0.4 5.18 0.3 4.33e-7 White blood cell types; CESC cis rs7274811 0.681 rs158676 chr20:31974395 G/A cg21523528 chr20:32077966 CBFA2T2 -0.54 -6.39 -0.37 7.55e-10 Height; CESC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg09060608 chr5:178986726 RUFY1 0.52 7.65 0.43 3.73e-13 Lung cancer; CESC cis rs6582630 0.502 rs1915395 chr12:38420726 A/G cg13010199 chr12:38710504 ALG10B 0.54 6.81 0.39 6.48e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs8067354 0.527 rs1292039 chr17:57974913 A/T cg13753209 chr17:57696993 CLTC 0.55 5.81 0.34 1.79e-8 Hemoglobin concentration; CESC cis rs3845702 0.736 rs72960660 chr2:180832482 A/G cg01881094 chr2:180872142 CWC22 1.05 8.97 0.48 5.61e-17 Schizophrenia; CESC cis rs4243830 0.677 rs1556035 chr1:6579607 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.67 -6.4 -0.37 7.15e-10 Body mass index; CESC cis rs7246657 0.882 rs10412043 chr19:37826626 A/C cg23950597 chr19:37808831 NA -0.55 -6.11 -0.35 3.53e-9 Coronary artery calcification; CESC cis rs7216064 0.906 rs8074644 chr17:65878217 G/C cg12091567 chr17:66097778 LOC651250 -0.81 -9.2 -0.49 1.14e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg13147721 chr7:65941812 NA 0.37 5.03 0.3 9.01e-7 Aortic root size; CESC cis rs7777484 0.534 rs2258709 chr7:2832365 C/T cg18446336 chr7:2847575 GNA12 0.36 6.07 0.35 4.52e-9 Height; CESC cis rs868036 1.000 rs7168156 chr15:68102933 T/C cg08079166 chr15:68083412 MAP2K5 0.43 6.92 0.39 3.35e-11 Restless legs syndrome; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05415408 chr7:30410993 DKFZP586I1420 -0.37 -6.38 -0.36 8.03e-10 Gambling; CESC cis rs1797885 0.934 rs299646 chr3:12540455 G/C cg26432171 chr3:12704882 RAF1 -0.46 -5.8 -0.34 1.89e-8 Immature fraction of reticulocytes; CESC cis rs9467711 0.606 rs9348726 chr6:26605206 G/A cg12826209 chr6:26865740 GUSBL1 0.66 5.84 0.34 1.54e-8 Autism spectrum disorder or schizophrenia; CESC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg27170947 chr2:26402098 FAM59B 0.83 8.97 0.48 5.73e-17 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03144560 chr20:55043299 C20orf43 0.51 6.23 0.36 1.87e-9 Gut microbiome composition (summer); CESC cis rs7208859 0.573 rs8070182 chr17:29135594 A/C cg14008862 chr17:28927542 LRRC37B2 0.63 5.15 0.3 5.09e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg17252645 chr8:143867129 LY6D -0.3 -5.41 -0.32 1.4e-7 Urinary tract infection frequency; CESC cis rs10504073 0.647 rs59064792 chr8:50018337 A/C cg00325661 chr8:49890786 NA 0.52 7.95 0.44 5.53e-14 Blood metabolite ratios; CESC cis rs7520050 0.831 rs61783170 chr1:46256329 T/C cg03146154 chr1:46216737 IPP -0.47 -6.13 -0.35 3.18e-9 Red blood cell count;Reticulocyte count; CESC cis rs6662572 0.737 rs72677533 chr1:46536558 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.16 0.3 4.9e-7 Blood protein levels; CESC cis rs17376456 0.825 rs6877030 chr5:93201841 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 5.05 0.3 8.28e-7 Diabetic retinopathy; CESC cis rs2228479 0.681 rs10153196 chr16:89967397 A/C cg04013166 chr16:89971882 TCF25 0.71 8.29 0.45 5.65e-15 Skin colour saturation; CESC cis rs763121 0.853 rs8142098 chr22:39058757 T/G cg06544989 chr22:39130855 UNC84B 0.49 8.49 0.46 1.53e-15 Menopause (age at onset); CESC cis rs6714710 0.603 rs953320 chr2:98606770 T/C cg26665480 chr2:98280029 ACTR1B 0.67 8.97 0.48 5.48e-17 Posterior cortical atrophy and Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02709064 chr8:142264163 NA 0.5 6.85 0.39 5.01e-11 Fibrinogen levels; CESC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.62 8.34 0.46 4.22e-15 Total body bone mineral density; CESC cis rs7512552 0.839 rs11577843 chr1:150398258 A/G cg15654264 chr1:150340011 RPRD2 0.4 5.3 0.31 2.4e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs5417 0.689 rs55868524 chr17:7170665 G/A cg13768953 chr17:7114967 DLG4 0.36 5.29 0.31 2.52e-7 Diastolic blood pressure; CESC cis rs300703 0.515 rs424292 chr2:191931 C/T cg21211680 chr2:198530 NA -0.92 -10.41 -0.54 1.63e-21 Blood protein levels; CESC cis rs2011503 1.000 rs11669730 chr19:19648713 G/A cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs1692580 0.846 rs377599 chr1:2164699 C/T cg24578937 chr1:2090814 PRKCZ 0.34 5.4 0.31 1.49e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18885365 chr1:40420800 MFSD2A 0.62 7.26 0.41 4.25e-12 Gut microbiome composition (summer); CESC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg26668828 chr6:292823 DUSP22 -0.71 -9.53 -0.51 1.07e-18 Menopause (age at onset); CESC cis rs8114671 0.562 rs2889861 chr20:33405664 C/T cg08999081 chr20:33150536 PIGU 0.4 5.82 0.34 1.68e-8 Height; CESC trans rs6934970 0.860 rs4631328 chr6:112983203 G/A cg05146922 chr2:10634174 NA -0.37 -6.17 -0.35 2.53e-9 Bipolar disorder (body mass index interaction); CESC cis rs7095944 0.582 rs2303611 chr10:126517989 G/A cg08799069 chr10:126477246 METTL10 -0.4 -5.7 -0.33 3.11e-8 Asthma; CESC cis rs7927592 0.913 rs6591344 chr11:68360873 G/A cg20283391 chr11:68216788 NA -0.61 -7.29 -0.41 3.48e-12 Total body bone mineral density; CESC cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg20503657 chr10:835505 NA 0.64 5.62 0.33 4.8e-8 Eosinophil percentage of granulocytes; CESC cis rs2857078 0.654 rs4793083 chr17:42312973 C/T cg19774624 chr17:42201019 HDAC5 0.54 7.19 0.4 6.71e-12 Red cell distribution width;Reticulocyte count; CESC cis rs854765 0.583 rs7222480 chr17:17818817 G/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.36 0.36 8.96e-10 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13451483 chr19:5720795 TMEM146;LONP1 -0.68 -8.33 -0.46 4.31e-15 Gut microbiome composition (summer); CESC cis rs6912958 0.535 rs1753153 chr6:88032834 T/G cg12350822 chr6:88032061 C6orf162;GJB7 0.5 8.62 0.47 6.32e-16 Monocyte percentage of white cells; CESC cis rs8014204 0.773 rs2241275 chr14:75251440 C/T cg08847533 chr14:75593920 NEK9 -0.44 -5.65 -0.33 4.03e-8 Caffeine consumption; CESC cis rs2115536 0.630 rs12102032 chr15:80233399 A/C cg00225070 chr15:80189496 MTHFS 0.44 5.6 0.33 5.26e-8 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs3126085 0.877 rs12116736 chr1:152167062 C/T cg03465714 chr1:152285911 FLG -0.45 -5.53 -0.32 7.5e-8 Atopic dermatitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05628496 chr17:17991167 DRG2 -0.42 -6.04 -0.35 5.12e-9 Gambling; CESC trans rs9850225 0.666 rs4603923 chr3:80997120 C/T cg27138204 chr12:54446100 HOXC4 0.39 6.41 0.37 6.75e-10 Erectile dysfunction in type 1 diabetes; CESC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg22963979 chr7:1858916 MAD1L1 -0.39 -5.32 -0.31 2.18e-7 Bipolar disorder and schizophrenia; CESC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg26314531 chr2:26401878 FAM59B -0.62 -6.93 -0.39 3.23e-11 Gut microbiome composition (summer); CESC cis rs7216064 0.651 rs12947658 chr17:65903006 A/G cg07042672 chr17:66097459 LOC651250 0.5 6.76 0.38 8.76e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4253772 0.513 rs11090863 chr22:46705407 C/T cg00784671 chr22:46762841 CELSR1 -0.54 -5.55 -0.32 6.85e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg09365446 chr1:150670422 GOLPH3L 0.38 5.28 0.31 2.65e-7 Tonsillectomy; CESC cis rs72781680 0.898 rs72786279 chr2:24063266 C/T cg20701182 chr2:24300061 SF3B14 0.62 5.6 0.33 5.24e-8 Lymphocyte counts; CESC cis rs1215050 0.740 rs783949 chr4:99001933 A/G cg17366294 chr4:99064904 C4orf37 -0.39 -5.18 -0.3 4.49e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7830933 0.955 rs1550280 chr8:23601830 C/T cg04349084 chr8:23602677 NA 0.43 5.36 0.31 1.8e-7 Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist-to-hip ratio adjusted for body mass index;Waist circumference adjusted for body mass index;Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI in non-smokers; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg07157834 chr1:205819609 PM20D1 0.85 13.84 0.65 3.67e-33 Menarche (age at onset); CESC cis rs8077577 0.747 rs62072544 chr17:18243873 C/T cg16794390 chr17:18148240 FLII 0.41 6.42 0.37 6.22e-10 Obesity-related traits; CESC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg21963583 chr11:68658836 MRPL21 0.39 5.5 0.32 8.94e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7216064 1.000 rs11079706 chr17:65835470 G/T cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.73e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7617480 0.585 rs7373072 chr3:48960017 T/A cg06212747 chr3:49208901 KLHDC8B 0.52 6.28 0.36 1.41e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14849479 chr5:60039648 NA -0.55 -6.74 -0.38 9.63e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15387272 chr1:36863509 LSM10 -0.54 -6.21 -0.36 2e-9 Gut microbiome composition (summer); CESC cis rs2250402 0.510 rs8031319 chr15:40323692 A/G cg16127683 chr15:40268777 EIF2AK4 -0.67 -5.82 -0.34 1.65e-8 Corneal curvature; CESC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg09359103 chr1:154839909 KCNN3 -0.65 -12.25 -0.6 1.22e-27 Prostate cancer; CESC cis rs4654899 0.785 rs7531381 chr1:21403348 A/G cg05370193 chr1:21551575 ECE1 0.36 5.47 0.32 1.06e-7 Superior frontal gyrus grey matter volume; CESC cis rs453301 0.653 rs1045529 chr8:8890098 A/G cg15556689 chr8:8085844 FLJ10661 -0.48 -5.96 -0.34 7.89e-9 Joint mobility (Beighton score); CESC cis rs7772486 0.806 rs4243478 chr6:146284560 A/G cg05347473 chr6:146136440 FBXO30 -0.49 -6.45 -0.37 5.39e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg08392591 chr16:89556376 ANKRD11 -0.41 -5.21 -0.3 3.81e-7 Multiple myeloma (IgH translocation); CESC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg09877947 chr5:131593287 PDLIM4 0.48 6.32 0.36 1.11e-9 Acylcarnitine levels; CESC cis rs6088590 0.965 rs6120727 chr20:33374102 T/C cg06115741 chr20:33292138 TP53INP2 0.6 7.39 0.41 1.96e-12 Coronary artery disease; CESC cis rs6696846 0.515 rs12739846 chr1:205096895 T/C cg00857998 chr1:205179979 DSTYK 0.39 5.23 0.31 3.44e-7 Red blood cell count; CESC cis rs921968 0.613 rs556497 chr2:219446477 G/A cg02176678 chr2:219576539 TTLL4 0.42 7.28 0.41 3.73e-12 Mean corpuscular hemoglobin concentration; CESC cis rs977987 0.806 rs11149833 chr16:75464002 G/C cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC cis rs7772486 0.686 rs1004752 chr6:146037822 G/A cg05347473 chr6:146136440 FBXO30 -0.52 -6.93 -0.39 3.22e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs3617 0.539 rs12629687 chr3:52950659 T/C cg07507251 chr3:52567010 NT5DC2 -0.34 -5.59 -0.32 5.55e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs12325245 0.536 rs3169293 chr16:58552959 A/G cg05725404 chr16:58534157 NDRG4 -0.61 -5.24 -0.31 3.27e-7 Schizophrenia; CESC trans rs208515 0.525 rs12204452 chr6:66680325 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 11.12 0.56 7.77e-24 Exhaled nitric oxide levels; CESC cis rs7223966 1.000 rs12325866 chr17:61755974 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.44 0.37 5.7e-10 Hip circumference adjusted for BMI;Body mass index; CESC trans rs116095464 0.558 rs73029475 chr5:206969 T/C cg00938859 chr5:1591904 SDHAP3 0.66 6.26 0.36 1.55e-9 Breast cancer; CESC cis rs79349575 0.783 rs962272 chr17:46978283 A/G cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.24e-10 Type 2 diabetes; CESC cis rs13191362 0.935 rs34603926 chr6:163266793 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.67 6.26 0.36 1.54e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9488822 0.676 rs11153593 chr6:116335131 C/A cg26893134 chr6:116381904 FRK 0.25 6.13 0.35 3.14e-9 Cholesterol, total;LDL cholesterol; CESC cis rs2288912 0.807 rs7251501 chr19:45455706 C/T cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.23e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs17181170 0.574 rs1386925 chr3:87208664 T/C ch.2.199792288R chr2:200084043 NA -0.46 -6.02 -0.35 5.93e-9 Prostate cancer; CESC cis rs16854884 0.580 rs1445422 chr3:143863909 G/A cg06585982 chr3:143692056 C3orf58 0.41 5.22 0.31 3.64e-7 Economic and political preferences (feminism/equality); CESC cis rs7927592 0.763 rs596494 chr11:68251054 T/G cg01657329 chr11:68192670 LRP5 -0.47 -6.26 -0.36 1.56e-9 Total body bone mineral density; CESC cis rs72634258 0.740 rs4489581 chr1:8174495 A/C cg00042356 chr1:8021962 PARK7 -0.53 -5.76 -0.33 2.32e-8 Inflammatory bowel disease; CESC cis rs829883 0.659 rs11109528 chr12:98951362 G/A cg25150519 chr12:98850993 NA -0.62 -7.43 -0.42 1.53e-12 Colorectal adenoma (advanced); CESC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.01 -0.52 3.21e-20 Developmental language disorder (linguistic errors); CESC cis rs2249625 1.000 rs2496513 chr6:72903990 C/A cg18830697 chr6:72922368 RIMS1 -0.44 -6.22 -0.36 1.88e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs11122272 0.735 rs2295420 chr1:231485640 C/T cg06096015 chr1:231504339 EGLN1 0.41 6.04 0.35 5.15e-9 Hemoglobin concentration; CESC cis rs9488822 0.676 rs7774952 chr6:116380909 A/G cg05304507 chr6:116381966 FRK 0.26 6.94 0.39 3.08e-11 Cholesterol, total;LDL cholesterol; CESC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg05617483 chr15:76483344 C15orf27 0.4 5.35 0.31 1.9e-7 Blood metabolite levels; CESC cis rs2486288 0.656 rs12911861 chr15:45566718 T/C cg21132104 chr15:45694354 SPATA5L1 -0.57 -6.71 -0.38 1.17e-10 Glomerular filtration rate; CESC cis rs9914544 0.966 rs9906795 chr17:18816740 G/A cg26378065 chr17:18585709 ZNF286B 0.47 6.05 0.35 4.82e-9 Educational attainment (years of education); CESC cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg11502198 chr6:26597334 ABT1 0.52 5.34 0.31 1.99e-7 Intelligence (multi-trait analysis); CESC cis rs11650494 0.908 rs78208413 chr17:47398282 G/A cg08112188 chr17:47440006 ZNF652 1.31 8.51 0.46 1.31e-15 Prostate cancer; CESC cis rs1451375 0.617 rs1807066 chr7:50543683 T/C cg14593290 chr7:50529359 DDC -0.53 -5.97 -0.34 7.74e-9 Malaria; CESC cis rs6570726 0.935 rs906774 chr6:145813770 T/C cg23711669 chr6:146136114 FBXO30 0.83 12.36 0.6 5.07e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs2456568 0.508 rs1607403 chr11:93660514 A/G cg26875233 chr11:93583750 C11orf90 -0.32 -5.66 -0.33 3.88e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg17143192 chr8:8559678 CLDN23 0.75 8.46 0.46 1.78e-15 Obesity-related traits; CESC cis rs116095464 0.558 rs6962 chr5:256509 G/A cg10591111 chr5:226296 SDHA -0.52 -5.76 -0.33 2.38e-8 Breast cancer; CESC cis rs2204008 0.806 rs11520229 chr12:38246448 C/A cg13010199 chr12:38710504 ALG10B 0.51 6.3 0.36 1.24e-9 Bladder cancer; CESC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.66 -7.37 -0.41 2.12e-12 Gut microbiome composition (summer); CESC cis rs71277158 0.688 rs888507 chr3:169811039 G/C cg04067573 chr3:169899625 PHC3 0.67 6.67 0.38 1.49e-10 Prostate cancer; CESC cis rs1707322 0.721 rs61784800 chr1:46178112 A/G cg03146154 chr1:46216737 IPP -0.76 -10.9 -0.56 4.26e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg05340658 chr4:99064831 C4orf37 -0.82 -12.66 -0.61 4.75e-29 Colonoscopy-negative controls vs population controls; CESC cis rs9902453 0.967 rs12450441 chr17:28495021 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.88 0.44 8.52e-14 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07908229 chr1:182353640 GLUL -0.61 -6.89 -0.39 3.98e-11 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.66 -7.45 -0.42 1.28e-12 Gut microbiome composition (summer); CESC cis rs7223966 1.000 rs11654335 chr17:61797579 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.68 0.38 1.4e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9929218 1.000 rs2113201 chr16:68815000 C/T cg02972257 chr16:68554789 NA 0.49 5.99 0.35 6.8e-9 Colorectal cancer; CESC cis rs8038465 0.550 rs11072431 chr15:73987642 T/A cg15420318 chr15:73925796 NPTN 0.45 6.47 0.37 4.76e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs3808502 0.549 rs1382563 chr8:11426790 C/G cg15556689 chr8:8085844 FLJ10661 0.52 6.59 0.38 2.42e-10 Neuroticism; CESC cis rs6061231 0.740 rs11698650 chr20:60958374 A/T cg06197360 chr20:60970103 CABLES2 -0.35 -5.06 -0.3 7.82e-7 Colorectal cancer; CESC cis rs1018836 0.632 rs7017295 chr8:91482356 C/T cg16814680 chr8:91681699 NA 0.61 8.73 0.47 2.96e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs71327718 1 rs71327718 chr3:125592857 C/G cg07211511 chr3:129823064 LOC729375 -0.88 -7.98 -0.44 4.31e-14 Metabolite levels (HVA/5-HIAA ratio); CESC cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg13902645 chr11:5959945 NA -0.64 -7.71 -0.43 2.55e-13 DNA methylation (variation); CESC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg27057461 chr7:158136379 PTPRN2 -0.33 -5.17 -0.3 4.6e-7 Calcium levels; CESC cis rs57502260 0.704 rs923346 chr11:68182375 T/C cg20283391 chr11:68216788 NA -0.58 -5.23 -0.31 3.41e-7 Total body bone mineral density (age 45-60); CESC trans rs9467711 0.539 rs34436535 chr6:26370365 G/C cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC trans rs6089829 0.962 rs6122344 chr20:61661738 C/T cg23505145 chr19:12996616 KLF1 0.52 6.7 0.38 1.24e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09199072 chr6:116692265 DSE 0.59 6.64 0.38 1.78e-10 Gut microbiome composition (summer); CESC cis rs11031096 0.617 rs12288918 chr11:4191466 G/T cg18678763 chr11:4115507 RRM1 -0.4 -5.18 -0.3 4.46e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg16590910 chr6:42928470 GNMT 0.45 6.43 0.37 5.88e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg22143856 chr6:28129313 ZNF389 0.42 5.26 0.31 2.91e-7 Parkinson's disease; CESC cis rs6893300 0.785 rs58386410 chr5:179205704 T/C cg14593053 chr5:179126677 CANX -0.49 -5.86 -0.34 1.34e-8 Resting heart rate; CESC cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg14820908 chr5:178986412 RUFY1 0.46 7.12 0.4 1.03e-11 Lung cancer; CESC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg09177884 chr7:1199841 ZFAND2A -0.52 -7.09 -0.4 1.23e-11 Longevity;Endometriosis; CESC cis rs854765 0.583 rs7207043 chr17:17819188 A/G cg16928487 chr17:17741425 SREBF1 -0.56 -9.74 -0.51 2.34e-19 Total body bone mineral density; CESC cis rs910316 0.726 rs175040 chr14:75469555 A/G cg16144293 chr14:75469539 EIF2B2 0.42 5.66 0.33 3.94e-8 Height; CESC cis rs7772486 0.790 rs2249147 chr6:146184999 T/C cg23711669 chr6:146136114 FBXO30 0.89 13.11 0.63 1.37e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs4253772 0.591 rs6007732 chr22:46652303 A/T cg24881330 chr22:46731750 TRMU 0.87 9.84 0.52 1.13e-19 LDL cholesterol;Cholesterol, total; CESC cis rs17401966 0.838 rs9332414 chr1:10326963 C/T cg15208524 chr1:10270712 KIF1B 0.42 5.54 0.32 7.36e-8 Hepatocellular carcinoma; CESC trans rs9329221 0.657 rs17694485 chr8:10114458 A/T cg15556689 chr8:8085844 FLJ10661 0.59 7.03 0.4 1.73e-11 Neuroticism; CESC cis rs56399783 0.614 rs73047368 chr7:2766396 G/T cg19731401 chr7:2775893 GNA12 0.66 5.62 0.33 4.75e-8 Childhood ear infection; CESC cis rs1620921 0.505 rs4708886 chr6:161206350 G/T cg01280913 chr6:161186852 NA -0.41 -6.2 -0.36 2.15e-9 Lipoprotein (a) - cholesterol levels; CESC cis rs2952156 0.883 rs8077172 chr17:37834977 G/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.1 -0.3 6.37e-7 Asthma; CESC cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 5.89 0.34 1.17e-8 Personality dimensions; CESC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.18 0.4 6.94e-12 Bipolar disorder; CESC cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg10523679 chr1:76189770 ACADM -0.69 -6.5 -0.37 4.03e-10 Blood metabolite levels;Acylcarnitine levels; CESC trans rs7615952 1.000 rs7615952 chr3:125649403 A/C cg07211511 chr3:129823064 LOC729375 1.09 16.22 0.71 1.47e-41 Blood pressure (smoking interaction); CESC cis rs11098499 0.954 rs35063680 chr4:120387102 T/C cg09307838 chr4:120376055 NA 0.95 13.96 0.65 1.42e-33 Corneal astigmatism; CESC cis rs3820928 0.904 rs60906902 chr2:227760034 C/T cg11843606 chr2:227700838 RHBDD1 -0.39 -5.15 -0.3 5.03e-7 Pulmonary function; CESC cis rs9814567 1.000 rs2056604 chr3:134312648 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.44 -0.32 1.21e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg22920501 chr2:26401640 FAM59B -0.93 -10.94 -0.56 3.12e-23 Gut microbiome composition (summer); CESC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg15595755 chr5:1867978 NA 0.5 8.01 0.44 3.67e-14 Cardiovascular disease risk factors; CESC cis rs7208859 0.623 rs3752020 chr17:29111125 T/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9649465 1.000 rs1073670 chr7:123345029 A/C cg04330084 chr7:123175371 IQUB -0.38 -5.16 -0.3 4.75e-7 Migraine; CESC cis rs17125944 0.615 rs12589020 chr14:53312002 C/T cg00686598 chr14:53173677 PSMC6 0.89 6.86 0.39 4.76e-11 Alzheimer's disease (late onset); CESC cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.15 0.3 4.98e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2721195 0.614 rs12719778 chr8:145879883 T/C cg17328964 chr8:145687451 CYHR1 -0.41 -5.47 -0.32 1.05e-7 Age at first birth; CESC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg06873352 chr17:61820015 STRADA 0.73 12.99 0.62 3.49e-30 Prudent dietary pattern; CESC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg10556349 chr10:835070 NA 0.76 6.36 0.36 8.79e-10 Eosinophil percentage of granulocytes; CESC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg27121462 chr16:89883253 FANCA 0.79 11.63 0.58 1.54e-25 Vitiligo; CESC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg23048001 chr7:2026167 MAD1L1 0.45 5.75 0.33 2.4e-8 Bipolar disorder and schizophrenia; CESC cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg20503657 chr10:835505 NA 0.67 6.01 0.35 6.13e-9 Eosinophil percentage of granulocytes; CESC cis rs919433 1.000 rs2889363 chr2:198163699 A/G cg10820045 chr2:198174542 NA -0.42 -6.44 -0.37 5.57e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs748404 0.587 rs9920879 chr15:43639770 A/G cg24053811 chr14:70265306 SLC10A1 0.43 6.11 0.35 3.52e-9 Lung cancer; CESC cis rs3126085 0.877 rs1552992 chr1:152171625 C/G cg26876637 chr1:152193138 HRNR 0.44 5.11 0.3 6.25e-7 Atopic dermatitis; CESC cis rs2304069 0.565 rs13183261 chr5:149421847 T/G cg12661370 chr5:149340060 SLC26A2 0.44 5.83 0.34 1.61e-8 HIV-1 control; CESC cis rs116095464 1.000 rs7721278 chr5:310530 G/A cg10591111 chr5:226296 SDHA -0.61 -5.81 -0.34 1.83e-8 Breast cancer; CESC cis rs1878931 0.668 rs11643983 chr16:3438865 G/A cg21433313 chr16:3507492 NAT15 -0.35 -5.3 -0.31 2.49e-7 Body mass index (adult); CESC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg11764359 chr7:65958608 NA -0.73 -9.66 -0.51 4.16e-19 Aortic root size; CESC cis rs2637266 0.626 rs846603 chr10:78570793 A/G cg18941641 chr10:78392320 NA -0.4 -7.23 -0.41 5.3e-12 Pulmonary function; CESC cis rs67478160 0.619 rs12886363 chr14:104273786 T/C cg01849466 chr14:104193079 ZFYVE21 -0.5 -6.76 -0.38 8.71e-11 Schizophrenia; CESC cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg05347473 chr6:146136440 FBXO30 -0.55 -6.97 -0.39 2.54e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs34779708 0.931 rs2148482 chr10:35348910 A/G cg04310649 chr10:35416472 CREM -0.53 -6.33 -0.36 1.02e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9291683 0.597 rs11722989 chr4:10126139 A/G cg00071950 chr4:10020882 SLC2A9 -0.54 -8.27 -0.45 6.63e-15 Bone mineral density; CESC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.25e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1950500 0.509 rs12882558 chr14:24819233 G/A cg16194253 chr14:24768981 DHRS1;C14orf21 0.47 5.6 0.33 5.39e-8 Height; CESC cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg16135276 chr10:459697 DIP2C -0.6 -5.64 -0.33 4.45e-8 Eosinophil percentage of granulocytes; CESC trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21659725 chr3:3221576 CRBN 0.77 11.76 0.59 5.47e-26 Intelligence (multi-trait analysis); CESC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg10691866 chr7:65817282 TPST1 0.33 5.54 0.32 7.11e-8 Aortic root size; CESC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg09323728 chr8:95962352 TP53INP1 -0.4 -8.97 -0.48 5.42e-17 Type 2 diabetes; CESC cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg11742103 chr11:62369870 EML3;MTA2 0.65 9.61 0.51 6.04e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6866344 0.570 rs1132336 chr5:178140090 C/T cg03877680 chr5:178157825 ZNF354A 0.83 10.2 0.53 7.8e-21 Neutrophil percentage of white cells; CESC cis rs9910055 0.530 rs2269908 chr17:42294198 G/C cg13607699 chr17:42295918 UBTF 0.81 12.59 0.61 8.66e-29 Total body bone mineral density; CESC cis rs1534166 0.647 rs7355929 chr3:133514190 C/T cg12373951 chr3:133503437 NA -0.35 -5.3 -0.31 2.49e-7 Alcohol consumption (transferrin glycosylation); CESC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg11644478 chr21:40555479 PSMG1 1.02 16.76 0.72 1.74e-43 Cognitive function; CESC cis rs9682041 0.627 rs11924474 chr3:170091333 T/G cg11886554 chr3:170076028 SKIL 0.56 5.64 0.33 4.46e-8 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs9486715 1.000 rs6899647 chr6:97065661 A/G cg06623918 chr6:96969491 KIAA0776 -0.86 -12.58 -0.61 9.16e-29 Headache; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25756398 chr11:93474621 C11orf54;TAF1D 0.57 6.86 0.39 4.88e-11 Gut microbiome composition (summer); CESC cis rs2072732 0.904 rs2993480 chr1:2973322 A/G cg03976712 chr1:2946727 NA -0.32 -5.48 -0.32 9.82e-8 Plateletcrit; CESC cis rs17826219 0.706 rs9905827 chr17:29192168 C/A cg19761014 chr17:28927070 LRRC37B2 0.73 5.72 0.33 2.92e-8 Body mass index; CESC cis rs6991838 0.584 rs7814841 chr8:66541563 A/G cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg13628971 chr7:2884303 GNA12 0.66 8.63 0.47 5.7e-16 Height; CESC trans rs2727020 0.567 rs1164687 chr11:49290669 G/A cg03929089 chr4:120376271 NA 0.71 9.26 0.49 7.34e-18 Coronary artery disease; CESC trans rs1814175 0.616 rs1794139 chr11:49910855 C/T cg03929089 chr4:120376271 NA -0.92 -15.04 -0.68 2.26e-37 Height; CESC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.820 rs13122709 chr4:120555356 T/A cg09307838 chr4:120376055 NA 0.88 12.29 0.6 9.04e-28 Corneal astigmatism; CESC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg03467027 chr4:99064603 C4orf37 0.47 5.97 0.34 7.51e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3733585 0.762 rs6449217 chr4:10009151 T/A cg02734326 chr4:10020555 SLC2A9 0.47 6.49 0.37 4.26e-10 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26343667 chr3:156391915 TIPARP;LOC100287227 0.53 6.2 0.36 2.19e-9 Gut microbiome composition (summer); CESC trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21659725 chr3:3221576 CRBN 0.83 13.55 0.64 3.87e-32 Intelligence (multi-trait analysis); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25202845 chr15:74753513 UBL7 -0.5 -6.06 -0.35 4.6e-9 Ulcerative colitis; CESC cis rs72781680 0.898 rs72786277 chr2:24062818 T/G cg20701182 chr2:24300061 SF3B14 0.62 5.6 0.33 5.24e-8 Lymphocyte counts; CESC cis rs9916302 0.904 rs9898170 chr17:37510092 T/C cg07936489 chr17:37558343 FBXL20 0.78 10.7 0.55 1.93e-22 Glomerular filtration rate (creatinine); CESC cis rs7772486 0.846 rs2492856 chr6:146323928 A/G cg05347473 chr6:146136440 FBXO30 0.51 6.77 0.38 8.28e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg10150615 chr22:24372951 LOC391322 -0.57 -7.66 -0.43 3.53e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19839588 chr6:42419466 TRERF1 -0.43 -6.37 -0.36 8.26e-10 Gambling; CESC cis rs6815814 0.898 rs5743592 chr4:38803063 A/G cg02016764 chr4:38805732 TLR1 -0.63 -7.47 -0.42 1.15e-12 Breast cancer; CESC cis rs2243480 1.000 rs13235972 chr7:65883605 C/T cg13147721 chr7:65941812 NA -0.95 -8.95 -0.48 6.27e-17 Diabetic kidney disease; CESC cis rs9322193 0.923 rs9689084 chr6:149960784 G/A cg07701084 chr6:150067640 NUP43 0.44 6.12 0.35 3.27e-9 Lung cancer; CESC cis rs778371 0.871 rs2675954 chr2:233750627 C/G cg08000102 chr2:233561755 GIGYF2 -0.82 -13.27 -0.63 3.72e-31 Schizophrenia; CESC cis rs6460942 1.000 rs17274870 chr7:12406221 G/T cg20607287 chr7:12443886 VWDE -0.8 -9.05 -0.49 3.2e-17 Coronary artery disease; CESC trans rs3808502 0.585 rs4549730 chr8:11239078 T/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.23 -0.36 1.83e-9 Neuroticism; CESC cis rs9584850 0.834 rs745639 chr13:99119279 C/T cg22223119 chr13:99095684 FARP1 -0.35 -5.05 -0.3 8.23e-7 Neuroticism; CESC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg04414720 chr1:150670196 GOLPH3L 0.45 5.96 0.34 8.13e-9 Tonsillectomy; CESC cis rs6748734 0.625 rs6437372 chr2:241822406 A/G cg04034577 chr2:241836375 C2orf54 0.32 5.85 0.34 1.47e-8 Urinary metabolites; CESC trans rs11098499 0.908 rs7695996 chr4:120322033 C/T cg25214090 chr10:38739885 LOC399744 0.72 9.92 0.52 6.25e-20 Corneal astigmatism; CESC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg27170947 chr2:26402098 FAM59B 0.66 7.3 0.41 3.32e-12 Gut microbiome composition (summer); CESC cis rs6580649 0.883 rs7967762 chr12:48420214 C/T cg05342945 chr12:48394962 COL2A1 0.52 5.89 0.34 1.2e-8 Lung cancer; CESC trans rs1116547 0.531 rs957777 chr5:112848654 C/T cg10115368 chr14:100435663 NA 0.52 6.13 0.35 3.21e-9 Cerebral amyloid angiopathy; CESC cis rs637571 0.557 rs1204649 chr11:65702776 A/C cg04055107 chr11:65626734 MUS81;CFL1 0.44 5.35 0.31 1.94e-7 Eosinophil percentage of white cells; CESC trans rs61931739 0.500 rs2389269 chr12:34034179 C/T cg26384229 chr12:38710491 ALG10B 0.59 8.24 0.45 8.06e-15 Morning vs. evening chronotype; CESC cis rs3740713 1.000 rs73438666 chr11:18456511 G/A cg23797887 chr11:18477753 LDHAL6A -0.53 -5.27 -0.31 2.89e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6088580 0.602 rs6059840 chr20:33030405 G/A cg08999081 chr20:33150536 PIGU 0.65 11.37 0.57 1.17e-24 Glomerular filtration rate (creatinine); CESC cis rs3806843 0.766 rs2251860 chr5:140048209 T/C cg26395211 chr5:140044315 WDR55 0.45 6.06 0.35 4.77e-9 Depressive symptoms (multi-trait analysis); CESC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg02807482 chr3:125708958 NA -0.4 -5.24 -0.31 3.28e-7 Blood pressure (smoking interaction); CESC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs6570726 0.846 rs371186 chr6:145886971 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.59 0.38 2.33e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg14393609 chr7:65229607 NA 0.46 6.04 0.35 5.09e-9 Calcium levels; CESC cis rs2404602 0.716 rs2404736 chr15:76875943 T/C cg26408565 chr15:76604113 ETFA -0.39 -5.5 -0.32 8.82e-8 Blood metabolite levels; CESC cis rs7011049 0.915 rs78887309 chr8:53860016 A/C cg26025543 chr8:53854495 NA 0.45 5.04 0.3 8.7e-7 Systolic blood pressure; CESC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg23978390 chr7:1156363 C7orf50 0.51 6.69 0.38 1.35e-10 Longevity;Endometriosis; CESC cis rs2637266 1.000 rs12260492 chr10:78365242 C/A cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs11098499 0.863 rs6833334 chr4:120504227 C/T cg09307838 chr4:120376055 NA 0.95 12.98 0.62 3.72e-30 Corneal astigmatism; CESC cis rs6032067 0.929 rs6032044 chr20:43819416 C/A cg10761708 chr20:43804764 PI3 0.53 6.36 0.36 8.83e-10 Blood protein levels; CESC cis rs4820539 0.934 rs3788348 chr22:23467946 G/C cg14186256 chr22:23484241 RTDR1 0.82 14.59 0.67 8.64e-36 Bone mineral density; CESC cis rs11690935 0.959 rs7572215 chr2:172634228 G/A cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.95 -0.68 4.66e-37 Schizophrenia; CESC cis rs3857536 0.740 rs9360191 chr6:66942454 A/T cg07460842 chr6:66804631 NA -0.41 -5.28 -0.31 2.71e-7 Blood trace element (Cu levels); CESC cis rs722599 0.562 rs2287400 chr14:75182937 G/A cg11812906 chr14:75593930 NEK9 0.42 5.09 0.3 6.71e-7 IgG glycosylation; CESC cis rs11098499 0.913 rs68128210 chr4:120137819 T/G cg09307838 chr4:120376055 NA 0.79 10.07 0.53 2.04e-20 Corneal astigmatism; CESC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg22823121 chr1:150693482 HORMAD1 0.47 6.54 0.37 3.17e-10 Melanoma; CESC cis rs7474896 0.583 rs12783272 chr10:38024885 T/G cg25427524 chr10:38739819 LOC399744 -0.52 -5.69 -0.33 3.4e-8 Obesity (extreme); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg08945452 chr1:10854445 CASZ1 -0.46 -6.39 -0.37 7.62e-10 Asthma; CESC cis rs2732480 0.500 rs2732461 chr12:48692802 C/A cg04545296 chr12:48745243 ZNF641 0.43 7.31 0.41 3.22e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6430585 0.583 rs4988201 chr2:136618507 A/G cg07169764 chr2:136633963 MCM6 1.29 19.97 0.78 9.47e-55 Corneal structure; CESC cis rs4979906 1.000 rs4325263 chr10:79444236 A/G cg07817648 chr10:79422355 NA -0.61 -6.5 -0.37 4e-10 Mortality in heart failure; CESC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg07343612 chr16:622815 PIGQ -0.55 -8.09 -0.45 2.15e-14 Height; CESC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.56 0.42 6.72e-13 Prudent dietary pattern; CESC cis rs3106136 0.872 rs2016476 chr4:95229004 G/A cg11021082 chr4:95130006 SMARCAD1 -0.42 -5.94 -0.34 8.87e-9 Capecitabine sensitivity; CESC cis rs3008870 0.755 rs12562761 chr1:67396739 C/T cg02640540 chr1:67518911 SLC35D1 0.45 5.42 0.32 1.33e-7 Lymphocyte percentage of white cells; CESC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs1707322 1.000 rs785467 chr1:46521559 A/T cg03146154 chr1:46216737 IPP -0.76 -10.26 -0.53 5.18e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2841233 0.681 rs2582558 chr14:105347488 A/G cg16576083 chr14:105354267 KIAA0284 -0.45 -6.8 -0.39 7.03e-11 IgG glycosylation; CESC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg22535103 chr8:58192502 C8orf71 -0.76 -8.74 -0.47 2.65e-16 Developmental language disorder (linguistic errors); CESC cis rs1395 0.778 rs4665959 chr2:27443256 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.46 6.04 0.35 5.05e-9 Blood metabolite levels; CESC cis rs4660306 1.000 rs7522705 chr1:45992300 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.41 5.43 0.32 1.25e-7 Homocysteine levels; CESC cis rs4974559 0.847 rs28477912 chr4:1331350 C/T cg02980000 chr4:1222292 CTBP1 0.74 6.85 0.39 5.11e-11 Systolic blood pressure; CESC cis rs3857536 0.673 rs7759888 chr6:66891922 T/C cg07460842 chr6:66804631 NA -0.4 -5.23 -0.31 3.47e-7 Blood trace element (Cu levels); CESC cis rs7017914 0.934 rs62508771 chr8:71692688 C/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.3 -0.31 2.38e-7 Bone mineral density; CESC cis rs10129255 0.500 rs2105989 chr14:107138216 C/T cg07958169 chr14:107095056 NA -0.55 -8.59 -0.47 7.47e-16 Kawasaki disease; CESC cis rs1218582 0.661 rs4845695 chr1:154911798 A/G cg09359103 chr1:154839909 KCNN3 -0.59 -10.27 -0.53 4.77e-21 Prostate cancer; CESC cis rs7845219 0.525 rs10956931 chr8:95930301 A/G cg23172400 chr8:95962367 TP53INP1 -0.36 -6.53 -0.37 3.25e-10 Type 2 diabetes; CESC cis rs1707322 1.000 rs12077546 chr1:46431806 C/T cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg02038168 chr22:39784481 NA -0.62 -7.88 -0.44 8.34e-14 Intelligence (multi-trait analysis); CESC cis rs9916302 0.904 rs8077104 chr17:37530510 A/G cg15445000 chr17:37608096 MED1 -0.41 -6.76 -0.38 8.97e-11 Glomerular filtration rate (creatinine); CESC cis rs7786808 0.782 rs7787923 chr7:158227312 A/G cg09998033 chr7:158218633 PTPRN2 -0.49 -7.83 -0.43 1.21e-13 Obesity-related traits; CESC cis rs17433780 1.000 rs17433780 chr1:89474818 C/T cg09516651 chr1:89888402 LOC400759 -0.59 -8.17 -0.45 1.29e-14 Carotid intima media thickness; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg18765753 chr7:1198926 ZFAND2A -0.59 -9.39 -0.5 2.78e-18 Longevity;Endometriosis; CESC cis rs9354308 0.933 rs12194424 chr6:66574007 T/C cg07460842 chr6:66804631 NA 0.67 7.6 0.42 5.23e-13 Metabolite levels; CESC cis rs965469 0.843 rs6051842 chr20:3397434 T/C cg25506879 chr20:3388711 C20orf194 -0.63 -6.55 -0.37 3.01e-10 IFN-related cytopenia; CESC cis rs9715521 0.867 rs4860465 chr4:59832537 G/T cg11281224 chr4:60001000 NA -0.51 -6.66 -0.38 1.53e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7520050 0.966 rs785479 chr1:46492144 C/T cg03146154 chr1:46216737 IPP -0.47 -6.06 -0.35 4.74e-9 Red blood cell count;Reticulocyte count; CESC cis rs2404602 0.684 rs12437981 chr15:76842401 A/G cg23625390 chr15:77176239 SCAPER -0.45 -6.24 -0.36 1.74e-9 Blood metabolite levels; CESC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg23758822 chr17:41437982 NA 1.04 16.01 0.7 7.99e-41 Menopause (age at onset); CESC cis rs34779708 0.931 rs12242882 chr10:35347860 G/C cg03585969 chr10:35415529 CREM 0.77 10.1 0.53 1.63e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs9296092 0.560 rs17627049 chr6:33537802 G/T cg13560919 chr6:33536144 NA -0.71 -10.84 -0.55 6.86e-23 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs12291225 0.535 rs10832248 chr11:14413087 G/A cg19336497 chr11:14380999 RRAS2 -0.36 -5.26 -0.31 2.92e-7 Sense of smell; CESC cis rs4148883 0.629 rs10009145 chr4:100047929 G/A cg13256891 chr4:100009986 ADH5 0.57 7.44 0.42 1.4e-12 Alcohol dependence; CESC cis rs4589502 1.000 rs8023363 chr15:67154654 G/A cg09911534 chr15:67153556 NA -0.45 -5.04 -0.3 8.76e-7 Lung cancer (smoking interaction); CESC cis rs4925386 0.840 rs6143024 chr20:60914229 A/G cg12382846 chr20:60892121 LAMA5 0.36 5.51 0.32 8.35e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs59918340 0.616 rs3739222 chr8:142205904 C/G cg23750338 chr8:142222470 SLC45A4 0.44 6.51 0.37 3.73e-10 Immature fraction of reticulocytes; CESC cis rs4820539 0.966 rs2267000 chr22:23455366 A/G cg14186256 chr22:23484241 RTDR1 0.79 14.12 0.66 4.03e-34 Bone mineral density; CESC cis rs1983891 0.955 rs4714487 chr6:41547312 T/C cg20194872 chr6:41519635 FOXP4 0.54 7.74 0.43 2.16e-13 Prostate cancer; CESC cis rs9948 0.786 rs62152774 chr2:97448377 A/G cg01990225 chr2:97406019 LMAN2L -0.92 -7.51 -0.42 9.04e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs4595586 0.870 rs1516558 chr12:39283119 A/G cg26384229 chr12:38710491 ALG10B -0.39 -5.48 -0.32 1.01e-7 Morning vs. evening chronotype; CESC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg18876405 chr7:65276391 NA 0.54 7.14 0.4 8.71e-12 Aortic root size; CESC cis rs6540556 0.769 rs6540553 chr1:209929044 C/G cg23920097 chr1:209922102 NA -0.39 -5.5 -0.32 9.14e-8 Red blood cell count; CESC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.95 10.4 0.54 1.84e-21 Mean platelet volume; CESC cis rs9467711 0.606 rs34622023 chr6:26362119 A/T cg14345882 chr6:26364793 BTN3A2 0.61 6.49 0.37 4.31e-10 Autism spectrum disorder or schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10519082 chr1:245026741 HNRNPU -0.53 -6.36 -0.36 8.61e-10 Ulcerative colitis; CESC cis rs6598955 0.670 rs4659366 chr1:26542572 G/A cg04990556 chr1:26633338 UBXN11 -0.72 -10.08 -0.53 1.9e-20 Obesity-related traits; CESC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg18446336 chr7:2847575 GNA12 -0.4 -6.0 -0.35 6.62e-9 Height; CESC cis rs7095944 0.584 rs11245347 chr10:126427037 G/T cg08799069 chr10:126477246 METTL10 -0.4 -5.73 -0.33 2.75e-8 Asthma; CESC cis rs9549260 0.785 rs2253001 chr13:41145330 A/T cg21288729 chr13:41239152 FOXO1 0.68 8.55 0.47 9.88e-16 Red blood cell count; CESC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg12463550 chr7:65579703 CRCP 0.58 7.41 0.41 1.67e-12 Aortic root size; CESC cis rs9611565 0.765 rs132921 chr22:41812044 G/A cg06634786 chr22:41940651 POLR3H 0.63 6.75 0.38 9.04e-11 Vitiligo; CESC cis rs2011503 0.714 rs7250233 chr19:19630948 C/T cg11584989 chr19:19387371 SF4 0.61 7.03 0.4 1.79e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02081925 chr5:176931394 DOK3 -0.57 -6.62 -0.38 1.95e-10 Gut microbiome composition (summer); CESC cis rs2985684 1.000 rs2985687 chr14:50100386 T/C cg15316458 chr14:50087796 RPL36AL;MGAT2 0.45 5.15 0.3 4.99e-7 Carotid intima media thickness; CESC trans rs4596713 0.507 rs1339546 chr9:71790297 G/A cg16512924 chr15:28394682 HERC2 0.48 6.1 0.35 3.8e-9 Headache; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01334186 chr1:151372572 PSMB4 -0.44 -6.06 -0.35 4.71e-9 Height; CESC cis rs9633740 0.947 rs1878036 chr10:82280137 T/G cg00277334 chr10:82204260 NA -0.56 -5.62 -0.33 4.82e-8 Post bronchodilator FEV1; CESC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg02569458 chr12:86230093 RASSF9 0.52 7.65 0.43 3.65e-13 Major depressive disorder; CESC cis rs4919087 0.715 rs793520 chr10:99032375 G/A cg25902810 chr10:99078978 FRAT1 -0.46 -5.15 -0.3 5.08e-7 Monocyte count; CESC cis rs7659604 1.000 rs28532673 chr4:122664323 A/G cg19671926 chr4:122722719 EXOSC9 0.43 5.15 0.3 4.99e-7 Type 2 diabetes; CESC cis rs1506636 1.000 rs644958 chr7:123400873 C/T cg03229431 chr7:123269106 ASB15 0.52 6.95 0.39 2.84e-11 Plateletcrit;Platelet count; CESC cis rs2354432 0.607 rs4950385 chr1:146656292 A/G cg25205988 chr1:146714368 CHD1L 1.19 9.08 0.49 2.58e-17 Mitochondrial DNA levels; CESC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.16 0.81 2.75e-62 Prudent dietary pattern; CESC cis rs7914558 1.000 rs7081075 chr10:104929191 C/T cg15744005 chr10:104629667 AS3MT -0.31 -5.04 -0.3 8.62e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.87 0.34 1.33e-8 Tonsillectomy; CESC trans rs9858542 0.953 rs11706370 chr3:49441091 G/A cg21659725 chr3:3221576 CRBN -0.55 -6.53 -0.37 3.38e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs17253792 0.545 rs35536987 chr14:56024021 A/G cg01858014 chr14:56050164 KTN1 -0.88 -6.38 -0.36 7.78e-10 Putamen volume; CESC cis rs6582630 0.519 rs10880194 chr12:38302836 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13338022 chr15:43029438 CDAN1 0.52 6.85 0.39 5.01e-11 Gut microbiota (bacterial taxa); CESC cis rs1018836 0.608 rs2142147 chr8:91468200 A/G cg16814680 chr8:91681699 NA -0.52 -7.17 -0.4 7.6e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9911578 0.933 rs11868348 chr17:57179238 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.07 0.3 7.47e-7 Intelligence (multi-trait analysis); CESC cis rs2652834 1.000 rs68088462 chr15:63397617 T/C cg05507819 chr15:63340323 TPM1 0.55 5.17 0.3 4.69e-7 HDL cholesterol; CESC cis rs3106136 0.843 rs901615 chr4:95228687 A/C cg11021082 chr4:95130006 SMARCAD1 -0.42 -5.93 -0.34 9.65e-9 Capecitabine sensitivity; CESC cis rs6594499 0.872 rs2112541 chr5:110449346 T/C cg04022379 chr5:110408740 TSLP 0.32 5.63 0.33 4.49e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs35955747 0.902 rs140074 chr22:31725634 C/G cg25791279 chr22:32026902 PISD 0.46 5.62 0.33 4.9e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs6087990 0.735 rs1040555 chr20:31380201 A/T cg13636640 chr20:31349939 DNMT3B -0.77 -12.59 -0.61 8.09e-29 Ulcerative colitis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04198824 chr13:31191332 USPL1 0.47 6.11 0.35 3.48e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4253772 0.575 rs9615983 chr22:46793314 G/A cg18190219 chr22:46762943 CELSR1 -0.63 -6.28 -0.36 1.36e-9 LDL cholesterol;Cholesterol, total; CESC cis rs7267979 0.966 rs2145126 chr20:25263648 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs1401999 1.000 rs4148575 chr3:183702275 A/G cg01324343 chr3:183735012 ABCC5 0.64 13.77 0.65 6.87e-33 Anterior chamber depth; CESC cis rs62432291 0.681 rs386818 chr6:159660255 T/C cg14500486 chr6:159655392 FNDC1 -0.62 -6.35 -0.36 9.1e-10 Joint mobility (Beighton score); CESC cis rs1348850 0.668 rs12618542 chr2:178494520 A/G cg23306229 chr2:178417860 TTC30B 0.6 6.89 0.39 4.07e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs113835537 0.529 rs10896125 chr11:66288733 G/C cg24851651 chr11:66362959 CCS 0.43 5.35 0.31 1.87e-7 Airway imaging phenotypes; CESC cis rs9488822 0.676 rs13210143 chr6:116389636 G/A cg05304507 chr6:116381966 FRK 0.27 6.99 0.39 2.26e-11 Cholesterol, total;LDL cholesterol; CESC cis rs9325144 0.513 rs7977596 chr12:38649067 C/A cg26384229 chr12:38710491 ALG10B -0.6 -8.49 -0.46 1.45e-15 Morning vs. evening chronotype; CESC cis rs2075371 0.897 rs10488428 chr7:133997560 C/T cg00033643 chr7:134001901 SLC35B4 0.4 5.1 0.3 6.33e-7 Mean platelet volume; CESC cis rs9913156 0.793 rs55884013 chr17:4579301 G/A cg19197139 chr17:4613644 ARRB2 0.88 9.6 0.51 6.59e-19 Lymphocyte counts; CESC cis rs1153858 0.668 rs63603561 chr15:45593323 T/A cg14582100 chr15:45693742 SPATA5L1 -0.37 -5.09 -0.3 6.85e-7 Homoarginine levels; CESC cis rs6496667 0.533 rs2601206 chr15:90962699 C/T cg22089800 chr15:90895588 ZNF774 0.47 6.09 0.35 3.93e-9 Rheumatoid arthritis; CESC cis rs72781680 0.716 rs2551326 chr2:23982378 T/C cg08917208 chr2:24149416 ATAD2B 0.57 5.62 0.33 4.79e-8 Lymphocyte counts; CESC cis rs10242455 0.702 rs74347626 chr7:99206021 G/T cg25640893 chr7:99214727 ZNF498 0.82 5.55 0.32 6.81e-8 Blood metabolite levels; CESC cis rs12545109 0.800 rs2670053 chr8:57421998 A/T cg09654669 chr8:57350985 NA -0.45 -6.27 -0.36 1.47e-9 Obesity-related traits; CESC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.51 0.46 1.28e-15 Intelligence (multi-trait analysis); CESC trans rs6695352 0.802 rs11120408 chr1:214970079 A/G cg07720334 chr2:25526752 DNMT3A 0.38 6.1 0.35 3.77e-9 Migraine without aura; CESC cis rs2070997 0.607 rs7027136 chr9:133668039 C/G cg11464064 chr9:133710261 ABL1 0.5 5.75 0.33 2.48e-8 Response to amphetamines; CESC cis rs1215050 0.740 rs2695464 chr4:98980929 T/C cg17366294 chr4:99064904 C4orf37 -0.39 -5.18 -0.3 4.3e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg02428538 chr16:24856791 SLC5A11 -0.6 -6.15 -0.35 2.77e-9 Intelligence (multi-trait analysis); CESC cis rs79839061 0.732 rs35177456 chr4:828994 C/T cg07828340 chr4:882639 GAK 0.88 6.18 0.36 2.37e-9 Intelligence (multi-trait analysis); CESC cis rs10979 0.557 rs9390116 chr6:143907577 A/G cg25407410 chr6:143891975 LOC285740 -0.49 -6.31 -0.36 1.16e-9 Hypospadias; CESC cis rs3806843 0.766 rs801176 chr5:140087010 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.39 -5.07 -0.3 7.33e-7 Depressive symptoms (multi-trait analysis); CESC cis rs4604732 1.000 rs4604732 chr1:247623872 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.42 -5.7 -0.33 3.23e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg22920501 chr2:26401640 FAM59B 0.91 10.33 0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs7959452 0.640 rs1598543 chr12:69688757 G/T cg14784868 chr12:69753453 YEATS4 0.73 10.57 0.54 5.06e-22 Blood protein levels; CESC cis rs2985684 0.894 rs2354439 chr14:50019417 G/C cg02151108 chr14:50098012 C14orf104 -0.4 -5.34 -0.31 1.97e-7 Carotid intima media thickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04350287 chr3:52326883 GLYCTK -0.56 -6.95 -0.39 2.79e-11 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.79 8.79 0.48 1.9e-16 Gut microbiome composition (summer); CESC cis rs12142240 0.698 rs72890727 chr1:46860237 G/A cg10495392 chr1:46806563 NSUN4 0.56 6.17 0.35 2.61e-9 Menopause (age at onset); CESC cis rs7560272 0.695 rs780394 chr2:73700930 A/G cg20560298 chr2:73613845 ALMS1 0.49 7.1 0.4 1.14e-11 Schizophrenia; CESC cis rs6577655 0.517 rs2241893 chr8:135586659 C/T cg17885191 chr8:135476712 NA 0.45 5.08 0.3 7.1e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs6460942 1.000 rs62448563 chr7:12400040 G/A cg13733410 chr7:12443478 VWDE -0.55 -5.4 -0.31 1.47e-7 Coronary artery disease; CESC cis rs9611519 0.929 rs9611466 chr22:41426299 A/T cg03806693 chr22:41940476 POLR3H -0.58 -6.03 -0.35 5.58e-9 Neuroticism; CESC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.95 10.25 0.53 5.58e-21 Platelet count; CESC cis rs1055129 0.537 rs2467100 chr17:73949038 C/G cg08125733 chr17:73851984 WBP2 0.48 6.54 0.37 3.17e-10 White matter hyperintensity burden; CESC cis rs3733585 0.673 rs4697914 chr4:9952266 G/A cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg22823121 chr1:150693482 HORMAD1 -0.48 -7.14 -0.4 8.85e-12 Tonsillectomy; CESC cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg14703610 chr5:56206110 C5orf35 0.53 7.18 0.4 7.15e-12 Coronary artery disease; CESC cis rs6912958 1.000 rs6454630 chr6:88171357 C/G cg08069147 chr6:88032118 GJB7;C6orf162 0.55 7.89 0.44 8.18e-14 Monocyte percentage of white cells; CESC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs3820068 0.581 rs16851819 chr1:15918739 C/T cg16988262 chr1:15930761 NA -0.33 -5.3 -0.31 2.43e-7 Systolic blood pressure; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg01446614 chr12:114404317 RBM19 0.54 6.14 0.35 2.95e-9 Psoriatic arthritis; CESC cis rs568617 0.953 rs645900 chr11:65648135 G/A cg19792802 chr11:65647270 CTSW -0.35 -5.31 -0.31 2.33e-7 Crohn's disease; CESC cis rs7927592 0.956 rs11228256 chr11:68251460 G/A cg16797656 chr11:68205561 LRP5 0.39 5.47 0.32 1.06e-7 Total body bone mineral density; CESC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg14173624 chr17:72199366 RPL38 0.49 6.84 0.39 5.45e-11 Weight; CESC trans rs7726839 0.540 rs4957080 chr5:644552 A/C cg25482853 chr8:67687455 SGK3 -0.93 -9.66 -0.51 4.28e-19 Obesity-related traits; CESC cis rs10504229 0.679 rs4737454 chr8:58033965 A/T cg24829409 chr8:58192753 C8orf71 -0.44 -5.73 -0.33 2.75e-8 Developmental language disorder (linguistic errors); CESC cis rs4253772 0.591 rs11705624 chr22:46685380 C/T cg00784671 chr22:46762841 CELSR1 -0.57 -5.5 -0.32 8.75e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6456156 0.586 rs12198816 chr6:167483546 G/A cg07741184 chr6:167504864 NA 0.36 6.22 0.36 1.9e-9 Primary biliary cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27242549 chr2:113012627 ZC3H8 0.58 7.0 0.4 2.08e-11 Gut microbiome composition (summer); CESC cis rs6963495 0.818 rs6973263 chr7:105170293 A/G cg13798780 chr7:105162888 PUS7 0.77 7.88 0.44 8.3e-14 Bipolar disorder (body mass index interaction); CESC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg27286337 chr10:134555280 INPP5A 0.68 7.69 0.43 2.81e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6540559 0.673 rs6698154 chr1:210007777 A/G cg23283495 chr1:209979779 IRF6 0.48 5.59 0.32 5.78e-8 Cleft lip with or without cleft palate; CESC cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.78 -10.94 -0.56 3.2e-23 Chronic sinus infection; CESC cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg11752832 chr7:134001865 SLC35B4 0.54 7.02 0.4 1.88e-11 Mean platelet volume; CESC cis rs7605827 0.897 rs11901455 chr2:15623888 C/T cg19274914 chr2:15703543 NA 0.33 5.95 0.34 8.34e-9 Educational attainment (years of education); CESC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.51 -0.5 1.22e-18 Alzheimer's disease; CESC cis rs4253772 0.637 rs3087501 chr22:46647909 A/G cg24881330 chr22:46731750 TRMU 0.87 9.74 0.51 2.4e-19 LDL cholesterol;Cholesterol, total; CESC cis rs965469 0.779 rs1884563 chr20:3335540 T/C cg25506879 chr20:3388711 C20orf194 -0.47 -5.07 -0.3 7.62e-7 IFN-related cytopenia; CESC cis rs10885582 0.781 rs10749168 chr10:116301983 T/C cg17056676 chr10:116301354 ABLIM1 -0.3 -5.38 -0.31 1.61e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs35110281 0.686 rs162399 chr21:44950020 G/A cg01579765 chr21:45077557 HSF2BP -0.55 -9.38 -0.5 3.03e-18 Mean corpuscular volume; CESC cis rs11608355 0.545 rs35590455 chr12:109893514 A/G cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10137463 chr15:23085908 NIPA1 -0.43 -6.21 -0.36 2.01e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg22535103 chr8:58192502 C8orf71 -1.05 -12.84 -0.62 1.17e-29 Developmental language disorder (linguistic errors); CESC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg04553112 chr3:125709451 NA -0.52 -5.47 -0.32 1.05e-7 Blood pressure (smoking interaction); CESC cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs9611565 0.559 rs8139993 chr22:41995335 T/C cg17376030 chr22:41985996 PMM1 0.49 5.47 0.32 1.05e-7 Vitiligo; CESC cis rs6429082 0.818 rs704706 chr1:235614378 G/A cg26050004 chr1:235667680 B3GALNT2 0.61 7.5 0.42 9.4e-13 Adiposity; CESC cis rs1348850 0.914 rs7604673 chr2:178392346 A/G cg23306229 chr2:178417860 TTC30B 0.64 8.04 0.44 2.92e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11958404 0.932 rs72816579 chr5:157431877 T/C cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs4970966 0.904 rs12131809 chr1:150544640 C/T cg13175981 chr1:150552382 MCL1 0.55 5.93 0.34 9.26e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg18180107 chr4:99064573 C4orf37 0.4 5.15 0.3 5.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7917772 0.636 rs7079231 chr10:104527341 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.43 5.23 0.31 3.45e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg02375832 chr11:62437615 C11orf48 -0.39 -5.64 -0.33 4.38e-8 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs17376456 1.000 rs67150649 chr5:93292377 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.65 5.37 0.31 1.75e-7 Diabetic retinopathy; CESC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg05754148 chr16:3507555 NAT15 -0.61 -9.47 -0.5 1.66e-18 Tuberculosis; CESC cis rs6024905 0.565 rs6024991 chr20:36970167 C/G cg07053727 chr20:36965646 BPI -0.52 -7.86 -0.43 9.68e-14 Bipolar disorder and schizophrenia; CESC cis rs11122272 0.732 rs999010 chr1:231495316 A/G cg06096015 chr1:231504339 EGLN1 0.42 6.12 0.35 3.3e-9 Hemoglobin concentration; CESC cis rs1355223 0.867 rs3818514 chr11:34680053 G/A cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.13 -0.35 3.2e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs1044826 1.000 rs13085888 chr3:139164874 C/T cg05129325 chr1:215255161 KCNK2 0.33 6.47 0.37 4.74e-10 Obesity-related traits; CESC cis rs13064411 0.696 rs6768979 chr3:113204149 G/A cg18753928 chr3:113234510 CCDC52 -0.52 -6.24 -0.36 1.73e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs4808199 0.948 rs7250368 chr19:19452763 G/A cg03709012 chr19:19516395 GATAD2A 1.07 11.98 0.59 9.93e-27 Nonalcoholic fatty liver disease; CESC cis rs3820928 1.000 rs10204368 chr2:227774244 G/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.74 -0.33 2.55e-8 Pulmonary function; CESC cis rs12682352 0.602 rs6988939 chr8:8666916 C/T cg17143192 chr8:8559678 CLDN23 0.44 5.29 0.31 2.55e-7 Neuroticism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01798391 chr3:16306595 OXNAD1;DPH3 0.47 6.09 0.35 3.95e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs10484885 0.824 rs28372875 chr6:90529343 C/T cg13799429 chr6:90582589 CASP8AP2 -0.76 -7.15 -0.4 8.35e-12 QRS interval (sulfonylurea treatment interaction); CESC cis rs1728785 0.818 rs1814299 chr16:68581332 G/A cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs9303401 0.659 rs12935851 chr17:56600244 C/A cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.92 0.62 6.16e-30 Cognitive test performance; CESC cis rs863345 0.604 rs1894040 chr1:158456336 C/T cg12129480 chr1:158549410 OR10X1 0.35 6.93 0.39 3.13e-11 Pneumococcal bacteremia; CESC cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg17971929 chr21:40555470 PSMG1 -0.57 -7.44 -0.42 1.45e-12 Menarche (age at onset); CESC cis rs4880487 0.888 rs10794730 chr10:1247022 C/T cg03183215 chr10:1252341 ADARB2 -0.34 -5.27 -0.31 2.88e-7 Migraine; CESC cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg22307297 chr20:60903441 LAMA5 0.37 5.15 0.3 5.04e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs2262909 0.962 rs4932952 chr19:22246788 G/A cg11619707 chr19:22235551 ZNF257 0.33 5.17 0.3 4.65e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs16854884 0.538 rs61359084 chr3:143738362 T/C cg06585982 chr3:143692056 C3orf58 0.5 6.46 0.37 4.94e-10 Economic and political preferences (feminism/equality); CESC cis rs6580649 0.941 rs4141065 chr12:48523499 G/A cg05342945 chr12:48394962 COL2A1 0.54 6.21 0.36 2.04e-9 Lung cancer; CESC cis rs2835872 0.733 rs1709822 chr21:39035485 A/G cg06728970 chr21:39037746 KCNJ6 0.3 5.51 0.32 8.67e-8 Electroencephalographic traits in alcoholism; CESC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg16680214 chr1:154839983 KCNN3 -0.43 -6.6 -0.38 2.2e-10 Prostate cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13606015 chr3:43732015 ABHD5 -0.45 -6.47 -0.37 4.83e-10 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10021668 chr1:159751259 DUSP23 0.56 6.22 0.36 1.92e-9 Gut microbiome composition (summer); CESC cis rs5758659 0.714 rs5758578 chr22:42490292 A/C cg00645731 chr22:42541494 CYP2D7P1 0.33 5.67 0.33 3.79e-8 Cognitive function; CESC cis rs1483890 0.642 rs9825845 chr3:69404572 C/A cg22125112 chr3:69402811 FRMD4B 0.38 5.13 0.3 5.52e-7 Resting heart rate; CESC cis rs9796 0.561 rs7173086 chr15:41509288 A/T cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.94 -0.39 3.09e-11 Menopause (age at onset); CESC cis rs4566357 1.000 rs6436650 chr2:227925097 C/T cg11843606 chr2:227700838 RHBDD1 -0.42 -5.37 -0.31 1.72e-7 Coronary artery disease; CESC cis rs782590 0.967 rs17278044 chr2:55748217 G/C cg18811423 chr2:55921094 PNPT1 0.8 12.38 0.61 4.26e-28 Metabolic syndrome; CESC cis rs6772849 0.930 rs9868579 chr3:128351054 C/T cg16766828 chr3:128327626 NA 0.32 5.37 0.31 1.71e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs7481584 0.962 rs12805426 chr11:3020580 C/T cg25174290 chr11:3078921 CARS -0.43 -5.36 -0.31 1.78e-7 Calcium levels; CESC cis rs477692 0.597 rs574831 chr10:131379190 C/T cg24747557 chr10:131355152 MGMT 0.37 5.23 0.31 3.4e-7 Response to temozolomide; CESC cis rs5758659 0.569 rs133293 chr22:42382797 G/A cg04733989 chr22:42467013 NAGA 0.45 5.87 0.34 1.27e-8 Cognitive function; CESC cis rs6674176 0.597 rs12127737 chr1:44402565 G/A cg12908607 chr1:44402522 ARTN -0.51 -8.0 -0.44 3.98e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24367984 chr17:1945160 OVCA2;DPH1 -0.47 -6.13 -0.35 3.09e-9 Ulcerative colitis; CESC cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg14416269 chr4:6271139 WFS1 0.47 7.84 0.43 1.07e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1609391 0.543 rs6761993 chr3:136625902 C/T cg15507776 chr3:136538369 TMEM22 0.82 11.97 0.59 1.08e-26 Neuroticism; CESC cis rs10197940 0.571 rs13393021 chr2:152413258 A/C cg06191203 chr2:152266755 RIF1 -0.44 -5.56 -0.32 6.44e-8 Lung cancer; CESC cis rs3892630 0.619 rs61062732 chr19:33304717 T/C cg22980127 chr19:33182716 NUDT19 1.15 15.15 0.68 8.77e-38 Red blood cell traits; CESC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg10691866 chr7:65817282 TPST1 0.33 5.52 0.32 8.27e-8 Aortic root size; CESC cis rs854765 0.583 rs66531105 chr17:17809001 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.19 0.45 1.1e-14 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17376960 chr17:7197987 YBX2 0.6 6.86 0.39 4.73e-11 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27445386 chr6:42897250 CNPY3 -0.38 -6.06 -0.35 4.78e-9 Gambling; CESC cis rs2011503 1.000 rs113527843 chr19:19643343 A/T cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC trans rs1814175 0.935 rs11040462 chr11:49683158 G/A cg03929089 chr4:120376271 NA -0.86 -13.1 -0.63 1.43e-30 Height; CESC cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg01475377 chr6:109611718 NA -0.49 -8.11 -0.45 1.85e-14 Reticulocyte fraction of red cells; CESC cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg27297192 chr10:134578999 INPP5A 0.4 5.37 0.31 1.72e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs56235845 0.694 rs12055081 chr5:176757191 C/T cg06060754 chr5:176797920 RGS14 0.44 5.42 0.32 1.37e-7 Hemoglobin concentration;Hematocrit; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00732428 chr17:46048392 CDK5RAP3 0.49 6.16 0.35 2.69e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4812048 0.793 rs7266693 chr20:57593158 T/C cg14073986 chr20:57617431 SLMO2 0.7 5.79 0.34 1.98e-8 Mean platelet volume; CESC cis rs6088580 0.609 rs6059844 chr20:33036482 A/G cg06115741 chr20:33292138 TP53INP2 0.46 6.0 0.35 6.3e-9 Glomerular filtration rate (creatinine); CESC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg22638593 chr5:131593259 PDLIM4 0.41 5.28 0.31 2.65e-7 Breast cancer; CESC cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.13 0.3 5.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg22823121 chr1:150693482 HORMAD1 0.4 5.58 0.32 5.89e-8 Melanoma; CESC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg22535103 chr8:58192502 C8orf71 -0.76 -8.73 -0.47 2.81e-16 Developmental language disorder (linguistic errors); CESC cis rs9868809 0.881 rs7631574 chr3:48663046 A/G cg06212747 chr3:49208901 KLHDC8B 0.6 5.45 0.32 1.15e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs3617 0.625 rs11922961 chr3:52868610 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.29 -5.06 -0.3 8.01e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC trans rs877282 0.583 rs10904564 chr10:819459 C/G cg22713356 chr15:30763199 NA 1.07 9.68 0.51 3.6e-19 Uric acid levels; CESC cis rs3750965 0.959 rs4930265 chr11:68855954 A/G cg01403660 chr11:68851641 TPCN2 0.41 5.35 0.31 1.91e-7 Hair color; CESC cis rs472402 0.560 rs10037161 chr5:6624294 C/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.48 -6.5 -0.37 4.03e-10 Response to amphetamines; CESC cis rs2243480 1.000 rs1723267 chr7:65473314 G/A cg25894440 chr7:65020034 NA -0.65 -5.63 -0.33 4.5e-8 Diabetic kidney disease; CESC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg03396347 chr1:1875803 NA -0.46 -7.21 -0.41 5.71e-12 Body mass index; CESC cis rs2197308 0.765 rs10880643 chr12:37926452 C/T cg26384229 chr12:38710491 ALG10B -0.54 -7.66 -0.43 3.57e-13 Morning vs. evening chronotype; CESC cis rs4820539 0.966 rs5751590 chr22:23486830 A/C cg14186256 chr22:23484241 RTDR1 0.84 14.8 0.67 1.51e-36 Bone mineral density; CESC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.46 -6.43 -0.37 5.79e-10 Electroencephalogram traits; CESC cis rs919433 0.927 rs1429412 chr2:198190894 A/G cg10820045 chr2:198174542 NA -0.43 -6.21 -0.36 1.99e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -5.69 -0.33 3.45e-8 Tonsillectomy; CESC cis rs2228479 0.850 rs17226980 chr16:89825065 G/A cg04013166 chr16:89971882 TCF25 0.79 6.75 0.38 9.14e-11 Skin colour saturation; CESC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg20151795 chr6:28129481 ZNF389 0.36 5.23 0.31 3.44e-7 Cardiac Troponin-T levels; CESC cis rs3820928 0.874 rs13419455 chr2:227850465 C/G cg11843606 chr2:227700838 RHBDD1 -0.43 -5.45 -0.32 1.15e-7 Pulmonary function; CESC cis rs8017423 0.967 rs8016385 chr14:90721946 G/A cg14092571 chr14:90743983 NA -0.55 -8.31 -0.45 5.07e-15 Mortality in heart failure; CESC cis rs2952156 0.920 rs907090 chr17:37833632 T/C cg19468946 chr17:37922297 IKZF3 -0.4 -5.11 -0.3 6.14e-7 Asthma; CESC cis rs7264396 0.635 rs6119672 chr20:34479767 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.2 -0.57 4.18e-24 Total cholesterol levels; CESC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.35e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg11494091 chr17:61959527 GH2 0.72 12.13 0.6 3.13e-27 Prudent dietary pattern; CESC cis rs1003719 0.612 rs2835652 chr21:38557408 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.13 -0.45 1.62e-14 Eye color traits; CESC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg21984481 chr17:79567631 NPLOC4 -0.33 -5.17 -0.3 4.7e-7 Eye color traits; CESC cis rs11098499 0.954 rs11734241 chr4:120416872 A/G cg24375607 chr4:120327624 NA 0.46 5.66 0.33 3.97e-8 Corneal astigmatism; CESC cis rs60154123 0.667 rs650854 chr1:210465315 G/C cg21951975 chr1:209979733 IRF6 0.45 6.0 0.35 6.37e-9 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05236530 chr12:7362357 PEX5 -0.6 -6.67 -0.38 1.5e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08958952 chr8:142262761 NA -0.54 -6.1 -0.35 3.7e-9 Gut microbiome composition (summer); CESC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg04315214 chr1:2043799 PRKCZ -0.45 -7.32 -0.41 2.89e-12 Height; CESC cis rs2859741 0.546 rs3845491 chr1:37497521 C/T cg09363841 chr1:37513479 NA -0.52 -7.65 -0.43 3.77e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs4969178 0.930 rs12601079 chr17:76400329 G/A cg05887092 chr17:76393375 PGS1 0.58 9.26 0.49 7e-18 HDL cholesterol levels; CESC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 5.02e-9 Prudent dietary pattern; CESC cis rs858239 0.600 rs7456915 chr7:23143049 T/C cg23682824 chr7:23144976 KLHL7 0.54 7.7 0.43 2.68e-13 Cerebrospinal fluid biomarker levels; CESC cis rs1580019 0.510 rs4723162 chr7:32543804 C/A cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.39 0.37 7.42e-10 Cognitive ability; CESC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg06505273 chr16:24850292 NA 0.51 5.85 0.34 1.43e-8 Intelligence (multi-trait analysis); CESC cis rs425277 0.917 rs262656 chr1:2088754 A/C cg04315214 chr1:2043799 PRKCZ -0.38 -5.25 -0.31 3.19e-7 Height; CESC cis rs2066819 0.892 rs77415512 chr12:56627300 A/G cg26804944 chr12:56660921 COQ10A -0.86 -5.22 -0.31 3.69e-7 Psoriasis vulgaris; CESC cis rs2760061 0.626 rs596208 chr1:228117982 G/C cg01973587 chr1:228161476 NA 0.36 5.44 0.32 1.22e-7 Diastolic blood pressure; CESC cis rs7818688 0.697 rs11782590 chr8:95970158 G/C cg16049864 chr8:95962084 TP53INP1 0.57 5.64 0.33 4.29e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1775715 0.870 rs10827001 chr10:32229734 C/T cg04359828 chr10:32216031 ARHGAP12 0.36 5.1 0.3 6.5e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs863345 0.967 rs10908682 chr1:158522760 C/T cg12129480 chr1:158549410 OR10X1 -0.32 -6.47 -0.37 4.65e-10 Pneumococcal bacteremia; CESC cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg25019033 chr10:957182 NA -0.62 -6.71 -0.38 1.19e-10 Eosinophil percentage of granulocytes; CESC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg09658497 chr7:2847517 GNA12 -0.43 -6.11 -0.35 3.57e-9 Height; CESC cis rs2991971 0.810 rs12119202 chr1:45925931 A/T cg05343316 chr1:45956843 TESK2 0.59 8.4 0.46 2.71e-15 High light scatter reticulocyte count; CESC cis rs12900413 0.687 rs28513927 chr15:90304471 T/G cg24249390 chr15:90295951 MESP1 -0.38 -5.2 -0.3 3.92e-7 Coronary artery aneurysm in Kawasaki disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14115740 chr9:98054883 FANCC -0.69 -7.78 -0.43 1.58e-13 Gut microbiome composition (summer); CESC cis rs4835473 0.831 rs7689328 chr4:144894921 A/C cg25736465 chr4:144833511 NA 0.39 5.97 0.34 7.43e-9 Immature fraction of reticulocytes; CESC cis rs317689 0.819 rs317683 chr12:69713630 T/G cg14784868 chr12:69753453 YEATS4 0.48 5.14 0.3 5.26e-7 Response to diuretic therapy; CESC cis rs7394190 0.748 rs2292307 chr10:75549916 C/A cg07699608 chr10:75541558 CHCHD1 0.64 5.19 0.3 4.15e-7 Incident atrial fibrillation; CESC cis rs1878931 0.580 rs4785932 chr16:3410456 C/G cg22508957 chr16:3507546 NAT15 -0.37 -5.39 -0.31 1.6e-7 Body mass index (adult); CESC cis rs2204008 0.606 rs6582502 chr12:38543352 C/T cg26384229 chr12:38710491 ALG10B -0.41 -5.44 -0.32 1.18e-7 Bladder cancer; CESC cis rs12545109 1.000 rs2217957 chr8:57313360 T/C cg09654669 chr8:57350985 NA -0.59 -7.68 -0.43 3.17e-13 Obesity-related traits; CESC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg02951883 chr7:2050386 MAD1L1 -0.44 -5.62 -0.33 4.93e-8 Bipolar disorder and schizophrenia; CESC cis rs9325144 0.624 rs7979541 chr12:39129679 T/C cg26384229 chr12:38710491 ALG10B -0.51 -7.07 -0.4 1.34e-11 Morning vs. evening chronotype; CESC cis rs911555 0.723 rs7144010 chr14:103869869 G/A cg24130564 chr14:104152367 KLC1 0.46 5.98 0.34 7.22e-9 Intelligence (multi-trait analysis); CESC cis rs66573146 0.831 rs66645969 chr4:6985614 G/A cg00086871 chr4:6988644 TBC1D14 1.17 7.59 0.42 5.62e-13 Granulocyte percentage of myeloid white cells; CESC cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg16339924 chr4:17578868 LAP3 0.74 9.68 0.51 3.59e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4975616 0.714 rs27069 chr5:1347128 C/T cg07493874 chr5:1342172 CLPTM1L -0.41 -7.58 -0.42 5.65e-13 Lung cancer; CESC cis rs9768139 0.733 rs10156158 chr7:158122287 G/T cg27057461 chr7:158136379 PTPRN2 -0.37 -5.71 -0.33 3.04e-8 Calcium levels; CESC cis rs611744 0.810 rs619227 chr8:109215100 C/A cg21045802 chr8:109455806 TTC35 0.48 5.87 0.34 1.29e-8 Dupuytren's disease; CESC trans rs11039798 0.925 rs12277669 chr11:48925316 A/T cg15704280 chr7:45808275 SEPT13 0.69 6.44 0.37 5.66e-10 Axial length; CESC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.19 0.4 6.58e-12 Height; CESC cis rs9660992 1.000 rs3851296 chr1:205253839 A/C cg21643547 chr1:205240462 TMCC2 -0.44 -6.93 -0.39 3.27e-11 Mean corpuscular volume;Mean platelet volume; CESC trans rs61931739 0.500 rs3924704 chr12:34557833 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.57 0.37 2.69e-10 Morning vs. evening chronotype; CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg10819733 chr22:24237672 NA -0.42 -6.04 -0.35 5.09e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9815354 0.767 rs17280980 chr3:41810949 A/T cg03022575 chr3:42003672 ULK4 0.68 6.06 0.35 4.7e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs3008870 1.000 rs2985795 chr1:67426223 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.04 14.57 0.67 9.76e-36 Lymphocyte percentage of white cells; CESC cis rs367943 0.966 rs348932 chr5:112812457 G/A cg12552261 chr5:112820674 MCC -0.62 -7.73 -0.43 2.27e-13 Type 2 diabetes; CESC cis rs7202877 0.706 rs40217 chr16:75480066 C/A cg04384234 chr16:75411784 CFDP1 0.52 5.99 0.35 6.91e-9 Type 2 diabetes;Type 1 diabetes; CESC cis rs12586317 0.547 rs114371385 chr14:35503724 G/A cg05294307 chr14:35346193 BAZ1A -0.51 -5.4 -0.31 1.49e-7 Psoriasis; CESC cis rs6942756 0.774 rs2694574 chr7:128908963 A/G cg02491457 chr7:128862824 NA 0.65 9.61 0.51 5.83e-19 White matter hyperintensity burden; CESC cis rs10489525 0.599 rs910622 chr1:115600424 A/G cg12756093 chr1:115239321 AMPD1 0.43 5.18 0.3 4.31e-7 Autism; CESC cis rs3733585 0.673 rs7376948 chr4:9954708 G/A cg02734326 chr4:10020555 SLC2A9 -0.41 -5.77 -0.33 2.21e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2236521 0.714 rs6062210 chr20:60890375 A/G cg09594475 chr20:60884601 LAMA5 0.49 6.73 0.38 1.06e-10 Pelvic organ prolapse; CESC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg02221750 chr19:17393354 ANKLE1 -0.5 -6.0 -0.35 6.45e-9 Systemic lupus erythematosus; CESC cis rs4899554 0.640 rs4899555 chr14:75719834 T/C cg18117039 chr14:75741733 NA 0.44 5.89 0.34 1.14e-8 Inflammatory bowel disease; CESC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.16 -0.63 8.66e-31 Developmental language disorder (linguistic errors); CESC cis rs4242434 0.672 rs10110443 chr8:22484296 C/G cg03733263 chr8:22462867 KIAA1967 0.75 11.35 0.57 1.41e-24 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs2066819 1.000 rs35526714 chr12:56634639 G/C cg26734620 chr12:56694298 CS 1.03 5.7 0.33 3.23e-8 Psoriasis vulgaris; CESC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg24531977 chr5:56204891 C5orf35 0.47 6.0 0.35 6.42e-9 Coronary artery disease; CESC cis rs59918340 0.764 rs4961256 chr8:142229946 G/A cg23750338 chr8:142222470 SLC45A4 0.62 9.42 0.5 2.26e-18 Immature fraction of reticulocytes; CESC cis rs7107174 1.000 rs901103 chr11:77931346 C/T cg02023728 chr11:77925099 USP35 0.54 6.93 0.39 3.2e-11 Testicular germ cell tumor; CESC trans rs208520 0.955 rs9345808 chr6:67008262 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.64 7.27 0.41 4.09e-12 Exhaled nitric oxide output; CESC trans rs3942852 0.806 rs10769317 chr11:48150712 T/C cg03929089 chr4:120376271 NA -0.57 -6.27 -0.36 1.43e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs7124681 0.565 rs2904127 chr11:47817290 A/G cg20307385 chr11:47447363 PSMC3 0.62 8.62 0.47 6.37e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC trans rs7944735 0.507 rs7396592 chr11:48100837 T/C cg03929089 chr4:120376271 NA -0.54 -6.29 -0.36 1.32e-9 Intraocular pressure; CESC cis rs36715 0.868 rs2546147 chr5:127552590 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.44 5.12 0.3 5.83e-7 Breast cancer; CESC cis rs13102973 0.931 rs6822196 chr4:135855582 T/A cg14419869 chr4:135874104 NA 0.33 5.12 0.3 5.79e-7 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21146912 chr2:172016068 TLK1 -0.56 -6.9 -0.39 3.83e-11 Gut microbiome composition (summer); CESC cis rs116095464 1.000 rs56700778 chr5:313186 A/T cg22496380 chr5:211416 CCDC127 -0.88 -5.58 -0.32 5.91e-8 Breast cancer; CESC cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg00701064 chr4:6280414 WFS1 0.72 12.0 0.59 8.66e-27 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4423214 0.592 rs10898211 chr11:71210677 T/C cg05163923 chr11:71159392 DHCR7 -0.57 -6.13 -0.35 3.24e-9 Vitamin D levels; CESC cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg20135002 chr11:47629003 NA -0.41 -5.21 -0.3 3.87e-7 Subjective well-being; CESC cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -6.7 -0.38 1.27e-10 Personality dimensions; CESC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg14664628 chr15:75095509 CSK -0.55 -6.87 -0.39 4.58e-11 Breast cancer; CESC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs2294693 0.945 rs13216361 chr6:41007046 C/T cg14769373 chr6:40998127 UNC5CL -0.46 -5.97 -0.34 7.43e-9 Gastric cancer;Non-cardia gastric cancer; CESC cis rs1570884 0.516 rs7334387 chr13:50172133 T/A cg08779649 chr13:50194554 NA 0.38 6.47 0.37 4.64e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg10351095 chr21:47802916 PCNT -0.48 -6.46 -0.37 5.1e-10 Testicular germ cell tumor; CESC cis rs1018836 0.851 rs7007129 chr8:91629790 T/G cg16814680 chr8:91681699 NA -0.77 -11.9 -0.59 1.89e-26 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg21918786 chr6:109611834 NA -0.39 -5.98 -0.34 7.14e-9 Reticulocyte fraction of red cells; CESC cis rs501120 1.000 rs634963 chr10:44760033 T/C cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.1e-11 Coronary artery disease;Coronary heart disease; CESC cis rs7923609 1.000 rs2393969 chr10:65140440 A/C cg01631684 chr10:65280961 REEP3 -0.44 -5.43 -0.32 1.29e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7520050 0.931 rs7526678 chr1:46374159 A/G cg24296786 chr1:45957014 TESK2 0.44 5.58 0.32 5.79e-8 Red blood cell count;Reticulocyte count; CESC cis rs9916302 0.821 rs1966915 chr17:37425262 A/C cg15445000 chr17:37608096 MED1 0.4 6.45 0.37 5.35e-10 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19191357 chr22:42196520 CCDC134 0.57 6.6 0.38 2.22e-10 Gut microbiome composition (summer); CESC cis rs7917772 0.629 rs1475646 chr10:104522564 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.45 -5.28 -0.31 2.64e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2228479 0.850 rs17233567 chr16:89813821 G/A cg04013166 chr16:89971882 TCF25 0.79 6.78 0.38 7.83e-11 Skin colour saturation; CESC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg11764359 chr7:65958608 NA -0.54 -7.08 -0.4 1.31e-11 Aortic root size; CESC cis rs6121246 0.529 rs6060144 chr20:30178624 A/G cg13852791 chr20:30311386 BCL2L1 0.63 5.94 0.34 8.93e-9 Mean corpuscular hemoglobin; CESC cis rs926938 0.584 rs360607 chr1:115392401 C/A cg12756093 chr1:115239321 AMPD1 0.5 7.11 0.4 1.07e-11 Autism; CESC cis rs1348850 0.874 rs952746 chr2:178306584 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.76 10.79 0.55 9.99e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg08859206 chr1:53392774 SCP2 0.6 8.96 0.48 5.76e-17 Monocyte count; CESC cis rs6570726 0.791 rs448939 chr6:145808320 T/C cg23711669 chr6:146136114 FBXO30 0.84 12.58 0.61 8.95e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs2486288 0.656 rs12908818 chr15:45571668 A/G cg21132104 chr15:45694354 SPATA5L1 -0.56 -6.7 -0.38 1.22e-10 Glomerular filtration rate; CESC cis rs3091242 0.933 rs9438904 chr1:25756860 T/C cg27572855 chr1:25598939 RHD 0.44 7.28 0.41 3.9e-12 Erythrocyte sedimentation rate; CESC cis rs589448 0.902 rs315131 chr12:69761839 T/G cg20891283 chr12:69753455 YEATS4 0.98 16.88 0.72 6.73e-44 Cerebrospinal fluid biomarker levels; CESC cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs5769765 0.955 rs8135963 chr22:50301476 T/C cg02269571 chr22:50332266 NA -0.49 -6.5 -0.37 4.02e-10 Schizophrenia; CESC cis rs6570726 0.791 rs9373464 chr6:145907167 T/C cg05347473 chr6:146136440 FBXO30 0.56 7.31 0.41 3.24e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.49 -6.06 -0.35 4.66e-9 Tonsillectomy; CESC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg26343298 chr8:95960752 TP53INP1 0.36 5.96 0.34 7.8e-9 Type 2 diabetes; CESC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg22823121 chr1:150693482 HORMAD1 0.4 5.64 0.33 4.46e-8 Melanoma; CESC cis rs7833986 0.501 rs2953909 chr8:56968200 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 6.89e-13 Height; CESC cis rs10129255 0.500 rs7161740 chr14:107184358 G/T cg23076370 chr14:107095027 NA -0.64 -9.58 -0.51 7.49e-19 Kawasaki disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01802344 chr1:155232042 SCAMP3 0.65 7.07 0.4 1.41e-11 Gut microbiome composition (summer); CESC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg05255149 chr17:80675120 FN3KRP -0.46 -5.16 -0.3 4.95e-7 Breast cancer; CESC cis rs847577 0.674 rs7790479 chr7:97713101 C/G cg24562669 chr7:97807699 LMTK2 0.63 10.27 0.53 4.67e-21 Breast cancer; CESC cis rs11247915 0.540 rs11582416 chr1:26677721 A/G cg04990556 chr1:26633338 UBXN11 0.66 7.18 0.4 7e-12 Obesity-related traits; CESC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg13114125 chr14:105738426 BRF1 -0.82 -10.21 -0.53 7.24e-21 Mean platelet volume;Platelet distribution width; CESC cis rs6714710 0.603 rs17488897 chr2:98365164 G/C cg26665480 chr2:98280029 ACTR1B 0.61 8.26 0.45 6.9e-15 Posterior cortical atrophy and Alzheimer's disease; CESC trans rs459571 0.959 rs2520100 chr9:136918137 A/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.67 -8.79 -0.48 1.98e-16 Platelet distribution width; CESC cis rs1008375 0.966 rs28441502 chr4:17598384 G/A cg02297831 chr4:17616191 MED28 0.46 5.57 0.32 6.2e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1642645 0.831 rs6600396 chr1:42489534 G/A cg16685388 chr1:42384056 HIVEP3 0.37 5.49 0.32 9.65e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg24531977 chr5:56204891 C5orf35 -0.71 -9.37 -0.5 3.25e-18 Type 2 diabetes; CESC cis rs9300255 0.568 rs1790102 chr12:123704890 G/A cg05973401 chr12:123451056 ABCB9 0.5 5.68 0.33 3.48e-8 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14799209 chr7:106809543 HBP1 0.63 7.49 0.42 1.06e-12 Gut microbiome composition (summer); CESC cis rs7927771 0.524 rs2170815 chr11:47875910 T/C cg20307385 chr11:47447363 PSMC3 0.62 8.73 0.47 2.91e-16 Subjective well-being; CESC cis rs7726839 0.561 rs4957048 chr5:583442 G/A cg09021430 chr5:549028 NA -0.43 -5.76 -0.33 2.29e-8 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23713156 chr17:80606235 WDR45L -0.42 -6.07 -0.35 4.5e-9 Fibrinogen levels; CESC cis rs9902453 0.967 rs1042173 chr17:28525011 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.82 0.43 1.28e-13 Coffee consumption (cups per day); CESC cis rs3815700 0.841 rs10410895 chr19:33093655 T/G cg24916020 chr19:33096688 ANKRD27 0.6 5.84 0.34 1.56e-8 Eosinophilic esophagitis; CESC cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC cis rs11098499 0.908 rs11729050 chr4:120300066 T/C cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC trans rs1728785 1.000 rs12918861 chr16:68566508 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs1375194 0.606 rs13393407 chr2:33818198 C/T cg04131969 chr2:33951647 MYADML -0.53 -6.58 -0.37 2.52e-10 Response to antidepressants in depression; CESC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg12516959 chr21:47718080 NA 0.48 6.49 0.37 4.27e-10 Testicular germ cell tumor; CESC cis rs60871478 0.636 rs61441144 chr7:897784 C/T cg15782153 chr7:917662 C7orf20 0.47 5.13 0.3 5.65e-7 Cerebrospinal P-tau181p levels; CESC cis rs11696501 0.688 rs6073855 chr20:44309670 C/T cg11783356 chr20:44313418 WFDC10B -0.34 -5.3 -0.31 2.4e-7 Brain structure; CESC cis rs1348850 0.757 rs2166554 chr2:178455824 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.61 0.42 4.94e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.84 0.59 2.99e-26 Alzheimer's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08977639 chr16:1047820 NA 0.48 6.52 0.37 3.59e-10 Gut microbiota (bacterial taxa); CESC cis rs10751667 0.666 rs10902242 chr11:949700 G/A cg06064525 chr11:970664 AP2A2 -0.48 -9.45 -0.5 1.86e-18 Alzheimer's disease (late onset); CESC cis rs479844 1.000 rs479844 chr11:65551957 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.51 -6.06 -0.35 4.54e-9 Allergic disease (asthma, hay fever or eczema);Atopic march;Atopic dermatitis; CESC trans rs71568191 1.000 rs1125266 chr6:104563389 A/G cg17383421 chr3:151599085 SUCNR1 -0.73 -6.06 -0.35 4.65e-9 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs72781680 0.821 rs1022346 chr2:24127849 T/C cg08917208 chr2:24149416 ATAD2B 0.57 5.62 0.33 4.79e-8 Lymphocyte counts; CESC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg04553112 chr3:125709451 NA -0.47 -5.34 -0.31 1.97e-7 Blood pressure (smoking interaction); CESC cis rs3020736 0.500 rs6002601 chr22:42489058 A/T cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC cis rs6499188 1.000 rs6499188 chr16:68674788 G/A cg02972257 chr16:68554789 NA -0.59 -6.84 -0.39 5.41e-11 Ulcerative colitis; CESC cis rs3806843 0.966 rs11741994 chr5:140145949 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.43 -5.61 -0.33 5.03e-8 Depressive symptoms (multi-trait analysis); CESC cis rs3857067 0.806 rs4693374 chr4:95086164 A/C cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.0 -0.48 4.43e-17 QT interval; CESC cis rs15676 0.783 rs4489410 chr9:131591649 A/C cg00228799 chr9:131580591 ENDOG -0.54 -6.69 -0.38 1.3100000000000001e-10 Blood metabolite levels; CESC cis rs854765 0.647 rs7211714 chr17:17986955 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.63 0.47 5.7e-16 Total body bone mineral density; CESC cis rs9462846 0.919 rs9471966 chr6:42891022 G/A cg02353165 chr6:42928485 GNMT 0.43 5.2 0.3 4.07e-7 Blood protein levels; CESC cis rs7927771 1.000 rs4752856 chr11:47648042 C/T cg20307385 chr11:47447363 PSMC3 -0.52 -6.33 -0.36 1.02e-9 Subjective well-being; CESC trans rs61869271 0.871 rs6585308 chr10:116727532 G/A cg17463145 chr7:79084011 MAGI2 0.3 6.14 0.35 3.01e-9 Tonsillectomy; CESC cis rs2635047 0.783 rs9952447 chr18:44784700 C/T cg24371990 chr18:44770781 NA 0.42 6.75 0.38 9.47e-11 Educational attainment; CESC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg10053473 chr17:62856997 LRRC37A3 0.61 8.05 0.44 2.72e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6088590 1.000 rs2076668 chr20:33437621 G/A cg08999081 chr20:33150536 PIGU 0.57 8.78 0.47 2.1e-16 Coronary artery disease; CESC cis rs10242455 0.867 rs2740560 chr7:99322320 T/A cg07715041 chr7:99302981 CYP3A7 -0.44 -5.48 -0.32 9.91e-8 Blood metabolite levels; CESC cis rs116095464 0.558 rs61492827 chr5:225774 A/G cg22857025 chr5:266934 NA -1.27 -18.88 -0.76 5.63e-51 Breast cancer; CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg22791324 chr7:157949174 PTPRN2 0.43 6.36 0.36 8.69e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg16325326 chr1:53192061 ZYG11B 0.53 7.5 0.42 9.67e-13 Monocyte count; CESC cis rs12478296 0.892 rs60545379 chr2:243034390 A/T cg06360820 chr2:242988706 NA -0.67 -7.52 -0.42 8.74e-13 Obesity-related traits; CESC cis rs6493487 0.512 rs12907367 chr15:51265986 A/G cg02338191 chr15:51200825 AP4E1 0.61 5.45 0.32 1.17e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg11168104 chr5:1857477 NA -0.37 -5.54 -0.32 7.3e-8 Cardiovascular disease risk factors; CESC cis rs10479542 0.929 rs10078796 chr5:178978883 T/A cg19723775 chr5:179050963 HNRNPH1 0.4 5.4 0.31 1.5e-7 Lung cancer; CESC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg13298116 chr11:62369859 EML3;MTA2 0.65 9.58 0.51 7.44e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs1593 0.734 rs4862670 chr4:187145423 A/T cg02012338 chr4:187126139 CYP4V2 0.64 5.13 0.3 5.65e-7 Activated partial thromboplastin time; CESC cis rs753778 0.962 rs4961341 chr8:142235154 G/T cg23750338 chr8:142222470 SLC45A4 0.38 5.36 0.31 1.79e-7 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs6964587 0.626 rs404 chr7:91544316 G/T cg17063962 chr7:91808500 NA -0.46 -6.57 -0.37 2.63e-10 Breast cancer; CESC cis rs11608355 0.545 rs33997929 chr12:109912064 C/T cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs2242116 0.796 rs7645278 chr3:46974100 A/C cg27129171 chr3:47204927 SETD2 0.55 7.11 0.4 1.05e-11 Birth weight; CESC cis rs3092073 0.624 rs13040315 chr20:44585793 A/G cg00125455 chr20:44574271 PCIF1 0.34 5.62 0.33 4.82e-8 Intelligence (multi-trait analysis); CESC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg05255149 chr17:80675120 FN3KRP 0.45 5.41 0.32 1.43e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04964416 chr10:105156287 PDCD11;USMG5 0.53 6.12 0.35 3.35e-9 Gut microbiome composition (summer); CESC cis rs921968 0.648 rs538483 chr2:219458656 T/C cg02176678 chr2:219576539 TTLL4 0.42 7.28 0.41 3.73e-12 Mean corpuscular hemoglobin concentration; CESC cis rs8062405 0.691 rs11646653 chr16:28922149 C/T cg08761264 chr16:28874980 SH2B1 0.43 5.31 0.31 2.35e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7296418 0.630 rs7974099 chr12:123771475 A/G cg05973401 chr12:123451056 ABCB9 0.45 5.62 0.33 4.75e-8 Platelet count; CESC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.85 0.34 1.43e-8 Melanoma; CESC cis rs2635047 0.905 rs7504798 chr18:44610879 A/G cg19077165 chr18:44547161 KATNAL2 -0.51 -7.05 -0.4 1.54e-11 Educational attainment; CESC cis rs314370 0.904 rs13244629 chr7:100509253 A/C cg10426581 chr7:100472382 SRRT 0.83 7.93 0.44 5.97e-14 Resting heart rate; CESC cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg11764359 chr7:65958608 NA 0.82 9.36 0.5 3.45e-18 Aortic root size; CESC cis rs2455799 0.573 rs2455834 chr3:15753641 A/G cg09340198 chr3:15902540 ANKRD28 -0.34 -5.31 -0.31 2.29e-7 Mean platelet volume; CESC cis rs9837602 1.000 rs923470 chr3:99757792 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 7.51 0.42 9.03e-13 Breast cancer; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg24739457 chr1:205821442 NA 0.5 6.45 0.37 5.18e-10 Menarche (age at onset); CESC cis rs10254118 0.757 rs6467491 chr7:133138761 A/G cg10665199 chr7:133106180 EXOC4 0.56 7.6 0.42 4.97e-13 Intelligence (multi-trait analysis); CESC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg03647317 chr4:187891568 NA -0.4 -5.85 -0.34 1.45e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs17253792 1.000 rs28616134 chr14:56178802 G/A cg01858014 chr14:56050164 KTN1 -0.91 -7.03 -0.4 1.8e-11 Putamen volume; CESC cis rs9303401 0.538 rs2240258 chr17:56458183 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.9 9.54 0.51 9.8e-19 Cognitive test performance; CESC cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg20476274 chr7:133979776 SLC35B4 0.64 9.27 0.49 6.83e-18 Mean platelet volume; CESC cis rs425277 1.000 rs381664 chr1:2088104 A/G cg04315214 chr1:2043799 PRKCZ -0.38 -5.41 -0.32 1.43e-7 Height; CESC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg25767906 chr1:53392781 SCP2 -0.44 -5.61 -0.33 4.98e-8 Monocyte count; CESC cis rs796364 0.806 rs10931890 chr2:201102055 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.74 -6.47 -0.37 4.78e-10 Schizophrenia; CESC trans rs591166 1.000 rs2331841 chr18:57828637 G/A cg05268347 chr19:41218064 ADCK4 -0.4 -6.22 -0.36 1.96e-9 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18436758 chr1:21113190 HP1BP3 -0.48 -6.67 -0.38 1.45e-10 Fibrinogen levels; CESC cis rs1707322 0.721 rs6665808 chr1:46162283 C/T cg05343316 chr1:45956843 TESK2 0.48 6.09 0.35 3.85e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs826838 1.000 rs1843881 chr12:38733706 A/G cg26384229 chr12:38710491 ALG10B -0.83 -14.96 -0.68 4.09e-37 Heart rate; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10950113 chr16:69166907 CHTF8;CIRH1A -0.49 -6.18 -0.35 2.38e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17172773 chr1:150980817 FAM63A;PRUNE 0.57 7.03 0.4 1.8e-11 Gut microbiome composition (summer); CESC cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg14784868 chr12:69753453 YEATS4 0.84 13.21 0.63 6.15e-31 Blood protein levels; CESC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.17 -0.3 4.59e-7 Total body bone mineral density; CESC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg11301795 chr4:187892539 NA -0.74 -12.08 -0.6 4.74e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs1018836 0.527 rs13268721 chr8:91481549 G/A cg16814680 chr8:91681699 NA -0.57 -7.53 -0.42 7.87e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2425143 1.000 rs56052651 chr20:34344084 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -7.52 -0.42 8.4e-13 Blood protein levels; CESC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.7 0.33 3.24e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7772486 0.658 rs4895683 chr6:146113654 T/A cg23711669 chr6:146136114 FBXO30 -0.91 -13.64 -0.64 1.86e-32 Lobe attachment (rater-scored or self-reported); CESC trans rs853679 0.599 rs13193295 chr6:28003228 C/G cg06606381 chr12:133084897 FBRSL1 -1.1 -8.34 -0.46 4.09e-15 Depression; CESC cis rs12477438 1.000 rs57846982 chr2:99921574 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -8.45 -0.46 1.98e-15 Chronic sinus infection; CESC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg12963246 chr6:28129442 ZNF389 0.59 7.68 0.43 3e-13 Depression; CESC cis rs3106136 0.843 rs7438414 chr4:95265822 T/C cg11021082 chr4:95130006 SMARCAD1 0.38 5.32 0.31 2.26e-7 Capecitabine sensitivity; CESC cis rs9399137 0.507 rs7771310 chr6:135272535 G/A cg24558204 chr6:135376177 HBS1L 0.74 9.79 0.52 1.59e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs939574 0.858 rs2891733 chr2:220135208 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.53 5.25 0.31 3.06e-7 Platelet distribution width; CESC cis rs753778 0.628 rs11579 chr8:142205132 G/A cg18755752 chr8:142205143 DENND3 -0.69 -10.33 -0.54 3.14e-21 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs67311347 0.866 rs9826419 chr3:40352051 G/A cg24209194 chr3:40518798 ZNF619 0.41 5.16 0.3 4.89e-7 Renal cell carcinoma; CESC cis rs9611565 0.694 rs202641 chr22:41833116 C/T cg06481639 chr22:41940642 POLR3H 0.53 5.84 0.34 1.56e-8 Vitiligo; CESC cis rs897984 0.806 rs8052245 chr16:30916430 C/G cg02466173 chr16:30829666 NA 0.48 8.27 0.45 6.45e-15 Dementia with Lewy bodies; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14002772 chr9:2047373 SMARCA2 0.47 6.02 0.35 5.83e-9 Fibrinogen levels; CESC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2797160 1.000 rs1739375 chr6:126012013 T/C cg05901451 chr6:126070800 HEY2 0.46 6.55 0.37 2.91e-10 Endometrial cancer; CESC cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs798943 0.686 rs7810755 chr7:120888382 A/G cg09857513 chr7:120969044 WNT16 -0.31 -5.14 -0.3 5.32e-7 Bone mineral density (paediatric, upper limb); CESC cis rs80130819 0.515 rs917055 chr12:48385576 A/G cg05342945 chr12:48394962 COL2A1 -0.6 -6.98 -0.39 2.39e-11 Prostate cancer; CESC cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg20607287 chr7:12443886 VWDE -0.69 -9.66 -0.51 4.2e-19 Coronary artery disease; CESC cis rs9910055 0.571 rs10208 chr17:42300278 C/T cg08499158 chr17:42289980 UBTF -0.45 -5.8 -0.34 1.9e-8 Total body bone mineral density; CESC cis rs8114671 0.562 rs6087649 chr20:33510662 A/G cg07148914 chr20:33460835 GGT7 0.45 5.9 0.34 1.09e-8 Height; CESC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg10295955 chr4:187884368 NA -1.07 -22.81 -0.81 1.92e-64 Lobe attachment (rater-scored or self-reported); CESC cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg02487422 chr3:49467188 NICN1 0.44 5.6 0.33 5.43e-8 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25252777 chr19:56709056 NA -0.57 -6.85 -0.39 5.07e-11 Gut microbiome composition (summer); CESC cis rs863345 0.604 rs6697656 chr1:158520737 A/G cg12129480 chr1:158549410 OR10X1 -0.34 -6.86 -0.39 4.78e-11 Pneumococcal bacteremia; CESC cis rs11650494 0.908 rs79768864 chr17:47446968 C/A cg08112188 chr17:47440006 ZNF652 1.2 7.97 0.44 4.66e-14 Prostate cancer; CESC cis rs2832191 0.716 rs7284006 chr21:30475186 T/A cg08807101 chr21:30365312 RNF160 0.93 14.01 0.65 9.35e-34 Dental caries; CESC cis rs2832077 0.689 rs2832055 chr21:30132382 C/G cg08807101 chr21:30365312 RNF160 0.54 6.25 0.36 1.67e-9 Cognitive test performance; CESC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg07153921 chr17:41440717 NA 0.38 5.15 0.3 5.13e-7 Menopause (age at onset); CESC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg11663144 chr21:46675770 NA -0.64 -10.02 -0.52 2.95e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00114383 chr16:28962172 NFATC2IP -0.43 -6.04 -0.35 5.3e-9 Asthma; CESC cis rs727505 1.000 rs7777947 chr7:124436063 T/G cg23710748 chr7:124431027 NA -0.37 -6.14 -0.35 2.99e-9 Lewy body disease; CESC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg21784768 chr11:537496 LRRC56 -0.56 -5.32 -0.31 2.19e-7 Body mass index; CESC cis rs992157 0.735 rs13430006 chr2:219113089 A/C cg00012203 chr2:219082015 ARPC2 -0.82 -11.39 -0.57 9.66e-25 Colorectal cancer; CESC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg02221750 chr19:17393354 ANKLE1 -0.54 -6.35 -0.36 9.31e-10 Systemic lupus erythematosus; CESC cis rs7659604 0.628 rs3828485 chr4:122722368 G/A cg20573242 chr4:122745356 CCNA2 0.57 6.87 0.39 4.64e-11 Type 2 diabetes; CESC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg03609598 chr5:56110824 MAP3K1 -0.5 -5.35 -0.31 1.86e-7 Initial pursuit acceleration; CESC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg02428538 chr16:24856791 SLC5A11 -0.48 -5.04 -0.3 8.68e-7 Intelligence (multi-trait analysis); CESC cis rs116095464 0.558 rs62347683 chr5:230331 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.69 0.33 3.34e-8 Breast cancer; CESC trans rs459571 0.959 rs465724 chr9:136910097 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.58 -7.57 -0.42 6.18e-13 Platelet distribution width; CESC cis rs2073300 1.000 rs6106655 chr20:23441982 C/G cg12062639 chr20:23401060 NAPB 0.77 5.68 0.33 3.48e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg13628971 chr7:2884303 GNA12 0.4 5.36 0.31 1.85e-7 Height; CESC cis rs2637266 0.627 rs1992396 chr10:78482228 T/C cg18941641 chr10:78392320 NA 0.41 7.69 0.43 2.89e-13 Pulmonary function; CESC trans rs6987853 0.830 rs9643888 chr8:42352007 T/C cg27650678 chr11:66636318 PC -0.46 -6.08 -0.35 4.13e-9 Mean corpuscular hemoglobin concentration; CESC cis rs17539620 0.624 rs7770107 chr6:154836862 A/G cg17771515 chr6:154831774 CNKSR3 0.59 5.85 0.34 1.43e-8 Lipoprotein (a) levels; CESC cis rs2652834 1.000 rs2729783 chr15:63403316 C/T cg05507819 chr15:63340323 TPM1 0.55 5.24 0.31 3.29e-7 HDL cholesterol; CESC cis rs9902453 0.808 rs56088359 chr17:28173659 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.22 0.45 9.05e-15 Coffee consumption (cups per day); CESC cis rs10242455 0.702 rs6977165 chr7:99269397 T/C cg25640893 chr7:99214727 ZNF498 0.78 5.27 0.31 2.84e-7 Blood metabolite levels; CESC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg09455208 chr3:40491958 NA 0.45 7.7 0.43 2.71e-13 Renal cell carcinoma; CESC trans rs3749237 0.964 rs7431078 chr3:49808190 G/A cg21659725 chr3:3221576 CRBN 0.53 6.33 0.36 1.06e-9 Resting heart rate; CESC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.76 -0.38 8.73e-11 Bipolar disorder; CESC cis rs11190604 0.945 rs7091356 chr10:102292268 G/C cg07080220 chr10:102295463 HIF1AN 0.69 6.48 0.37 4.37e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs826838 0.510 rs10876149 chr12:39228083 C/G cg13010199 chr12:38710504 ALG10B -0.59 -7.99 -0.44 4.04e-14 Heart rate; CESC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg22105103 chr4:187893119 NA 0.51 7.39 0.41 1.91e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6665290 0.904 rs11586604 chr1:227183865 G/T cg10327440 chr1:227177885 CDC42BPA -1.21 -32.66 -0.89 6.96e-95 Myeloid white cell count; CESC cis rs1801251 1.000 rs283486 chr2:233644223 A/G cg08000102 chr2:233561755 GIGYF2 0.66 9.34 0.5 4.08e-18 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13920768 chr9:133557644 PRDM12 0.58 7.2 0.4 6.09e-12 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs79244293 chr16:89896220 T/C cg04013166 chr16:89971882 TCF25 0.72 5.71 0.33 3.01e-8 Skin colour saturation; CESC cis rs9549367 0.713 rs3024743 chr13:113821430 C/T cg00898013 chr13:113819073 PROZ -0.5 -7.04 -0.4 1.64e-11 Platelet distribution width; CESC cis rs11608355 0.515 rs12818537 chr12:109902150 C/T cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs7940866 0.903 rs1433980 chr11:130870956 A/G cg12179176 chr11:130786555 SNX19 0.63 9.32 0.5 4.66e-18 Schizophrenia; CESC cis rs6121246 0.697 rs6088857 chr20:30226764 G/C cg13852791 chr20:30311386 BCL2L1 0.73 7.51 0.42 9.16e-13 Mean corpuscular hemoglobin; CESC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg09849774 chr21:43526787 UMODL1;C21orf128 -0.46 -5.72 -0.33 2.89e-8 IgG glycosylation; CESC cis rs11785400 0.793 rs4403386 chr8:143736770 C/G cg24634471 chr8:143751801 JRK 0.46 5.91 0.34 1.06e-8 Schizophrenia; CESC cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg18876405 chr7:65276391 NA 0.53 6.88 0.39 4.2e-11 Aortic root size; CESC cis rs72781680 0.948 rs72796385 chr2:24170360 T/A cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs1348850 0.537 rs3770010 chr2:178537796 T/C cg22681709 chr2:178499509 PDE11A -0.48 -7.7 -0.43 2.77e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs13191362 0.507 rs2849520 chr6:163132038 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.67 -7.91 -0.44 7.23e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9815354 0.638 rs113496706 chr3:42028574 G/T cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs2637266 0.846 rs2637260 chr10:78320346 C/T cg18941641 chr10:78392320 NA -0.38 -7.32 -0.41 2.91e-12 Pulmonary function; CESC cis rs870825 0.616 rs7667409 chr4:185650941 C/T cg04058563 chr4:185651563 MLF1IP -0.63 -6.98 -0.39 2.36e-11 Blood protein levels; CESC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg22823121 chr1:150693482 HORMAD1 0.45 6.3 0.36 1.24e-9 Melanoma; CESC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg23281280 chr6:28129359 ZNF389 0.6 8.0 0.44 3.86e-14 Parkinson's disease; CESC cis rs7216064 0.817 rs28609796 chr17:65855104 T/A cg12091567 chr17:66097778 LOC651250 -0.87 -8.93 -0.48 7.41e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2204008 0.744 rs8189486 chr12:38244968 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.11 0.53 1.52e-20 Bladder cancer; CESC cis rs79976124 0.879 rs77185357 chr6:66629070 G/A cg07460842 chr6:66804631 NA 0.7 8.21 0.45 9.9e-15 Type 2 diabetes; CESC cis rs660899 0.595 rs37455 chr1:44294228 A/G cg11704212 chr1:44303111 ST3GAL3 -0.38 -5.28 -0.31 2.74e-7 Hypertension risk in short sleep duration; CESC cis rs2845885 0.744 rs2701540 chr11:63869107 T/A cg24431193 chr11:63883947 FLRT1;MACROD1 -0.85 -7.65 -0.43 3.67e-13 Body mass index; CESC cis rs12477438 0.520 rs6739579 chr2:99731552 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.61 0.69 2.15e-39 Chronic sinus infection; CESC cis rs12477438 0.798 rs12477754 chr2:99628073 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs9399137 0.507 rs11757723 chr6:135291293 C/T cg22676075 chr6:135203613 NA 0.53 7.0 0.39 2.15e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs1018836 0.923 rs2187982 chr8:91556317 G/T cg16814680 chr8:91681699 NA -0.74 -11.15 -0.57 6.08e-24 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9527 0.614 rs2153774 chr10:104881035 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.29e-8 Developmental language disorder (linguistic errors); CESC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg00802000 chr16:706648 WDR90 -0.41 -6.2 -0.36 2.15e-9 Height; CESC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg21248554 chr2:27665150 KRTCAP3 -0.37 -7.68 -0.43 3.02e-13 Total body bone mineral density; CESC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg14196790 chr5:131705035 SLC22A5 0.36 5.37 0.31 1.7e-7 Breast cancer;Mosquito bite size; CESC cis rs4654899 0.758 rs1354792 chr1:21391875 C/T cg05370193 chr1:21551575 ECE1 -0.33 -5.15 -0.3 4.99e-7 Superior frontal gyrus grey matter volume; CESC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg22549504 chr19:17448937 GTPBP3 -0.5 -5.56 -0.32 6.47e-8 Systemic lupus erythematosus; CESC cis rs9811920 0.609 rs4244713 chr3:99679584 T/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.59 -7.14 -0.4 8.97e-12 Axial length; CESC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs533123 0.877 rs482692 chr1:29154255 T/C cg08366446 chr1:29138936 OPRD1 0.54 5.55 0.32 6.92e-8 Schizophrenia; CESC cis rs7605827 0.930 rs7596969 chr2:15513615 C/G cg19274914 chr2:15703543 NA -0.31 -5.51 -0.32 8.31e-8 Educational attainment (years of education); CESC cis rs6460942 1.000 rs6948314 chr7:12418363 T/A cg20607287 chr7:12443886 VWDE -0.68 -8.18 -0.45 1.17e-14 Coronary artery disease; CESC cis rs737337 0.623 rs3810308 chr19:11333596 T/C cg00586551 chr19:11347513 LOC55908;DOCK6 0.54 5.66 0.33 4.02e-8 HDL cholesterol;HDL cholesterol levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08286599 chr2:191208694 INPP1 -0.44 -6.32 -0.36 1.12e-9 Gambling; CESC trans rs1814175 0.817 rs12290508 chr11:49621037 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -19.13 -0.76 7.6900000000000007e-52 Height; CESC cis rs1023500 0.573 rs133377 chr22:42466950 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.42 -5.04 -0.3 8.6e-7 Schizophrenia; CESC cis rs9910055 0.530 rs8072954 chr17:42294722 G/A cg08499158 chr17:42289980 UBTF -0.41 -5.25 -0.31 3.19e-7 Total body bone mineral density; CESC cis rs2228479 0.850 rs9282681 chr16:89805914 T/C cg04013166 chr16:89971882 TCF25 0.76 6.56 0.37 2.75e-10 Skin colour saturation; CESC cis rs1505368 0.817 rs6435701 chr2:213283512 A/G cg16329650 chr2:213403929 ERBB4 0.4 5.64 0.33 4.34e-8 Symmetrical dimethylarginine levels; CESC cis rs4862750 0.872 rs7664463 chr4:187876686 A/C cg11301795 chr4:187892539 NA -0.77 -12.86 -0.62 9.98e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 1.000 rs1935615 chr6:145921117 G/T cg23711669 chr6:146136114 FBXO30 0.67 9.61 0.51 5.87e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg07507251 chr3:52567010 NT5DC2 0.42 7.27 0.41 4.17e-12 Bipolar disorder; CESC cis rs4595586 0.967 rs56149694 chr12:39263771 T/C cg26384229 chr12:38710491 ALG10B -0.39 -5.49 -0.32 9.39e-8 Morning vs. evening chronotype; CESC cis rs12928939 0.517 rs12149307 chr16:71968091 A/C cg03805757 chr16:71968109 PKD1L3 -0.59 -6.63 -0.38 1.93e-10 Post bronchodilator FEV1; CESC cis rs10911232 0.507 rs4422969 chr1:183020762 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.5 0.64 6.03e-32 Hypertriglyceridemia; CESC cis rs4853012 0.887 rs6737314 chr2:74339586 A/G cg20891558 chr2:74357851 NA 0.69 9.12 0.49 1.95e-17 Gestational age at birth (maternal effect); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg03518469 chr16:88791646 FAM38A 0.44 6.2 0.36 2.15e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs7395662 0.500 rs1605360 chr11:48685714 G/A cg15704280 chr7:45808275 SEPT13 -0.56 -6.81 -0.39 6.57e-11 HDL cholesterol; CESC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg10351095 chr21:47802916 PCNT -0.48 -6.53 -0.37 3.31e-10 Testicular germ cell tumor; CESC cis rs11190604 1.000 rs3750719 chr10:102248950 C/G cg07080220 chr10:102295463 HIF1AN 0.62 5.58 0.32 5.82e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15385386 chr5:133968421 SAR1B 0.55 6.21 0.36 2e-9 Gut microbiome composition (summer); CESC cis rs6920364 1 rs6920364 chr6:167376466 G/C cg25258033 chr6:167368657 RNASET2 -0.4 -6.11 -0.35 3.49e-9 Lung cancer; CESC trans rs6460942 0.915 rs7803051 chr7:12306904 A/T cg16269144 chr1:2003326 PRKCZ 0.51 6.11 0.35 3.54e-9 Coronary artery disease; CESC cis rs2204008 0.624 rs2320449 chr12:38224190 T/C cg26384229 chr12:38710491 ALG10B 0.74 10.68 0.55 2.27e-22 Bladder cancer; CESC cis rs7296418 0.738 rs1568428 chr12:123738876 A/G cg00376283 chr12:123451042 ABCB9 -0.63 -8.89 -0.48 9.96e-17 Platelet count; CESC cis rs4835473 0.897 rs4835474 chr4:144903597 A/C cg25736465 chr4:144833511 NA 0.41 6.25 0.36 1.64e-9 Immature fraction of reticulocytes; CESC cis rs2274273 0.870 rs61210954 chr14:55765402 T/C cg04306507 chr14:55594613 LGALS3 0.3 5.9 0.34 1.1e-8 Protein biomarker; CESC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg24675658 chr1:53192096 ZYG11B 0.54 6.8 0.39 6.96e-11 Monocyte count; CESC cis rs34375054 0.526 rs883315 chr12:125676889 T/C cg00522288 chr12:125625016 AACS -0.33 -5.14 -0.3 5.44e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs12620999 1.000 rs4377286 chr2:238069686 C/T cg23555395 chr2:238036564 NA -0.57 -7.74 -0.43 2.08e-13 Systemic lupus erythematosus; CESC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg24531977 chr5:56204891 C5orf35 -0.88 -11.65 -0.58 1.32e-25 Initial pursuit acceleration; CESC cis rs6963495 0.818 rs73192126 chr7:105175415 T/C cg13798780 chr7:105162888 PUS7 0.77 7.87 0.44 9.18e-14 Bipolar disorder (body mass index interaction); CESC cis rs7666738 0.830 rs28417716 chr4:98864859 C/T cg17366294 chr4:99064904 C4orf37 0.55 7.72 0.43 2.38e-13 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.592 rs9611613 chr22:41961831 T/C cg03806693 chr22:41940476 POLR3H -0.97 -12.1 -0.6 4e-27 Vitiligo; CESC cis rs7481584 0.624 rs693687 chr11:3052494 A/G cg25174290 chr11:3078921 CARS -0.45 -6.33 -0.36 1.05e-9 Calcium levels; CESC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg03351412 chr1:154909251 PMVK 0.69 9.39 0.5 2.91e-18 Prostate cancer; CESC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg04511125 chr2:88470314 THNSL2 0.69 6.61 0.38 2.14e-10 Plasma clusterin levels; CESC cis rs9828933 0.752 rs73117082 chr3:63947565 A/G cg16258503 chr3:63850278 ATXN7;THOC7 -0.93 -8.12 -0.45 1.8e-14 Type 2 diabetes; CESC cis rs11608355 0.545 rs6606723 chr12:109905044 C/G cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs13106227 0.576 rs6843293 chr4:77392092 A/G cg20311846 chr4:77356250 SHROOM3 0.29 5.57 0.32 6.34e-8 Eosinophilic esophagitis (pediatric); CESC cis rs36051895 0.559 rs6476949 chr9:5208048 G/A cg02405213 chr9:5042618 JAK2 -0.47 -5.75 -0.33 2.42e-8 Pediatric autoimmune diseases; CESC trans rs35110281 0.720 rs162372 chr21:44928863 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.54 -7.3 -0.41 3.42e-12 Mean corpuscular volume; CESC cis rs10870270 0.913 rs4550 chr10:133781798 C/T cg17892150 chr10:133769511 PPP2R2D -0.86 -12.54 -0.61 1.24e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7937682 0.889 rs542424 chr11:111477698 T/C cg09085632 chr11:111637200 PPP2R1B -0.95 -14.8 -0.67 1.55e-36 Primary sclerosing cholangitis; CESC cis rs6674176 0.561 rs4660263 chr1:44421433 A/C cg12908607 chr1:44402522 ARTN -0.47 -6.66 -0.38 1.55e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06522697 chr10:121356224 TIAL1 0.53 6.13 0.35 3.16e-9 Gut microbiome composition (summer); CESC cis rs6812193 0.518 rs28649105 chr4:77185879 A/G cg20311846 chr4:77356250 SHROOM3 0.28 5.07 0.3 7.61e-7 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26675934 chr16:2009675 NDUFB10 0.6 6.76 0.38 8.77e-11 Gut microbiome composition (summer); CESC cis rs12579753 0.917 rs11115058 chr12:82263427 T/C cg23701643 chr12:82153290 PPFIA2 -0.36 -5.21 -0.3 3.89e-7 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10169971 chr6:83902988 RWDD2A;PGM3 0.63 6.94 0.39 3.04e-11 Gut microbiome composition (summer); CESC cis rs17854409 0.881 rs68091818 chr20:61479882 A/C cg05147244 chr20:61493195 TCFL5 1.0 7.45 0.42 1.33e-12 Obesity-related traits; CESC cis rs4253311 0.736 rs2292423 chr4:187175722 T/A cg24794857 chr4:187113578 CYP4V2 0.41 5.17 0.3 4.6e-7 Plasma renin activity levels;Circulating chromogranin peptide levels;Blood metabolite levels; CESC cis rs524281 0.731 rs10791840 chr11:65803383 T/C cg14036092 chr11:66035641 RAB1B -0.61 -5.63 -0.33 4.57e-8 Electroencephalogram traits; CESC cis rs7100689 0.577 rs9421464 chr10:82043426 C/T cg09936400 chr10:82049201 MAT1A 0.39 5.97 0.34 7.79e-9 Post bronchodilator FEV1; CESC cis rs3749237 0.595 rs1464568 chr3:49458266 G/A cg07636037 chr3:49044803 WDR6 0.59 8.58 0.47 8.1e-16 Resting heart rate; CESC cis rs4843747 0.671 rs72818540 chr16:88078988 C/T cg06915872 chr16:87998081 BANP 0.48 5.74 0.33 2.63e-8 Menopause (age at onset); CESC cis rs7089973 0.604 rs7895830 chr10:116625776 A/G cg03647239 chr10:116582469 FAM160B1 0.47 6.05 0.35 4.79e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2070488 0.775 rs2268762 chr3:38516075 A/G cg24069376 chr3:38537580 EXOG 0.36 6.09 0.35 4.04e-9 Electrocardiographic conduction measures; CESC cis rs971768 0.892 rs62623403 chr22:17595175 C/T cg24435209 chr22:17640972 CECR5;CECR4 -0.57 -5.61 -0.33 5.04e-8 Heschl's gyrus morphology; CESC cis rs6991838 0.584 rs1053088 chr8:66515783 A/G cg13398993 chr8:66546079 ARMC1 0.43 5.19 0.3 4.25e-7 Intelligence (multi-trait analysis); CESC cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg26769984 chr7:1090371 C7orf50 -0.65 -7.53 -0.42 7.91e-13 Bronchopulmonary dysplasia; CESC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.89 0.34 1.2e-8 Electroencephalogram traits; CESC cis rs6543140 0.964 rs6543142 chr2:103082006 T/C cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs3126085 0.735 rs4845744 chr1:152185095 T/A cg03465714 chr1:152285911 FLG -0.43 -5.16 -0.3 4.81e-7 Atopic dermatitis; CESC cis rs977987 0.806 rs1549306 chr16:75415341 A/G cg03315344 chr16:75512273 CHST6 0.41 5.89 0.34 1.19e-8 Dupuytren's disease; CESC trans rs877282 0.853 rs7079299 chr10:756455 A/G cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs7809950 0.861 rs10264412 chr7:107183877 G/A cg23024343 chr7:107201750 COG5 -0.57 -7.1 -0.4 1.15e-11 Coronary artery disease; CESC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg26335602 chr6:28129616 ZNF389 -0.46 -6.1 -0.35 3.8e-9 Depression; CESC cis rs61931739 0.500 rs10772160 chr12:34456848 G/A cg23762105 chr12:34175262 ALG10 -0.4 -5.22 -0.31 3.7e-7 Morning vs. evening chronotype; CESC cis rs933688 0.938 rs12110065 chr5:90718474 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 15.23 0.68 4.62e-38 Smoking behavior; CESC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.09 0.6 4.37e-27 Alzheimer's disease; CESC cis rs7635838 0.892 rs9852530 chr3:11466469 C/T cg00170343 chr3:11313890 ATG7 0.43 5.7 0.33 3.27e-8 HDL cholesterol; CESC cis rs7666738 0.546 rs10440329 chr4:98903735 C/T cg05340658 chr4:99064831 C4orf37 0.59 7.43 0.42 1.47e-12 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.906 rs2270607 chr8:58194699 A/G cg22535103 chr8:58192502 C8orf71 -0.86 -10.7 -0.55 1.88e-22 Developmental language disorder (linguistic errors); CESC trans rs12599106 0.715 rs34006830 chr16:34878550 C/A cg07332563 chr6:291687 DUSP22 -0.66 -8.12 -0.45 1.78e-14 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11466523 chr7:148923132 ZNF282 0.52 6.8 0.39 6.84e-11 Fibrinogen levels; CESC trans rs324780 0.544 rs3112090 chr12:83917047 C/T cg22140261 chr22:42466895 NAGA 0.48 6.11 0.35 3.55e-9 Vertical cup-disc ratio; CESC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg10691866 chr7:65817282 TPST1 0.32 5.31 0.31 2.33e-7 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11342046 chr2:242641489 ING5 -0.43 -6.39 -0.37 7.36e-10 Gambling; CESC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg12379764 chr21:47803548 PCNT -0.51 -6.16 -0.35 2.68e-9 Testicular germ cell tumor; CESC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg08888203 chr3:10149979 C3orf24 0.53 7.06 0.4 1.42e-11 Alzheimer's disease; CESC cis rs62064224 0.554 rs9889352 chr17:30775761 T/C cg18200150 chr17:30822561 MYO1D 0.41 5.28 0.31 2.64e-7 Schizophrenia; CESC cis rs826838 1.000 rs4768328 chr12:39129315 C/T cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs9309473 0.948 rs10199224 chr2:73761446 C/G cg20560298 chr2:73613845 ALMS1 -0.53 -6.97 -0.39 2.54e-11 Metabolite levels; CESC cis rs35146811 1.000 rs35146811 chr7:99720994 A/C cg13334819 chr7:99746414 C7orf59 -0.43 -5.09 -0.3 6.71e-7 Coronary artery disease; CESC cis rs55883249 1.000 rs62119422 chr2:9726599 A/G cg23886495 chr2:9695866 ADAM17 0.6 5.6 0.33 5.39e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs67311347 1.000 rs9834052 chr3:40399060 G/A cg24209194 chr3:40518798 ZNF619 0.45 5.96 0.34 8.08e-9 Renal cell carcinoma; CESC cis rs34375054 0.573 rs12811438 chr12:125653490 C/T cg25124228 chr12:125621409 AACS -0.56 -6.02 -0.35 5.74e-9 Post bronchodilator FEV1/FVC ratio; CESC cis rs7927592 0.830 rs7120635 chr11:68261293 A/G cg20283391 chr11:68216788 NA -0.5 -6.44 -0.37 5.47e-10 Total body bone mineral density; CESC cis rs7208859 0.623 rs55938328 chr17:29117010 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg09913183 chr17:42254507 C17orf65;ASB16 0.61 8.0 0.44 3.92e-14 Total body bone mineral density; CESC cis rs11690935 0.589 rs62182403 chr2:172747182 G/A cg13550731 chr2:172543902 DYNC1I2 0.46 6.34 0.36 1e-9 Schizophrenia; CESC cis rs2243480 1.000 rs11538349 chr7:65421871 C/T cg13147721 chr7:65941812 NA -0.8 -8.13 -0.45 1.67e-14 Diabetic kidney disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13495574 chr1:173793781 CENPL;DARS2 -0.43 -6.04 -0.35 5.25e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs116095464 1.000 rs3777237 chr5:307641 C/T cg22857025 chr5:266934 NA -1.28 -7.56 -0.42 6.67e-13 Breast cancer; CESC cis rs1008375 0.900 rs12650220 chr4:17595365 A/T cg15017067 chr4:17643749 FAM184B 0.36 5.13 0.3 5.53e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg16545954 chr1:2118288 C1orf86 0.35 6.54 0.37 3.11e-10 Height; CESC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg11494091 chr17:61959527 GH2 0.37 5.15 0.3 5.19e-7 Height; CESC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg05776053 chr2:74358815 NA 0.46 5.18 0.3 4.42e-7 Gestational age at birth (maternal effect); CESC cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg25405998 chr7:65216604 CCT6P1 0.48 5.34 0.31 2e-7 Aortic root size; CESC cis rs9858542 0.953 rs7646366 chr3:49470668 G/A cg03060546 chr3:49711283 APEH -0.53 -6.04 -0.35 5.26e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs61931739 0.892 rs61931711 chr12:34045374 C/T cg26384229 chr12:38710491 ALG10B -0.46 -6.16 -0.35 2.75e-9 Morning vs. evening chronotype; CESC cis rs7220401 0.789 rs4794859 chr17:27962393 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.5 -6.18 -0.35 2.4e-9 Coronary artery disease; CESC cis rs4243830 0.850 rs10746502 chr1:6607199 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.87 -8.64 -0.47 5.53e-16 Body mass index; CESC cis rs10089 0.903 rs6862701 chr5:127391249 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.15 0.53 1.14e-20 Ileal carcinoids; CESC cis rs17376456 0.757 rs6859757 chr5:93206042 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.14 0.3 5.36e-7 Diabetic retinopathy; CESC cis rs561341 0.941 rs2470236 chr17:30304940 G/C cg12193833 chr17:30244370 NA -0.57 -5.86 -0.34 1.37e-8 Hip circumference adjusted for BMI; CESC cis rs796364 0.806 rs4673634 chr2:200863349 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.83 7.5 0.42 9.65e-13 Schizophrenia; CESC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg06784218 chr1:46089804 CCDC17 -0.29 -5.06 -0.3 7.93e-7 High light scatter reticulocyte count; CESC cis rs10078 0.571 rs2671890 chr5:456457 A/G cg08916839 chr5:415575 AHRR 0.59 6.81 0.39 6.34e-11 Fat distribution (HIV); CESC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.32 0.31 2.16e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04620334 chr12:122985487 ZCCHC8 0.58 6.42 0.37 6.2e-10 Gut microbiome composition (summer); CESC cis rs1371867 0.810 rs1618528 chr8:101259134 T/C cg06002616 chr8:101225028 SPAG1 0.31 5.05 0.3 8.3e-7 Atrioventricular conduction; CESC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg23758822 chr17:41437982 NA 1.0 14.95 0.68 4.7e-37 Menopause (age at onset); CESC cis rs8072100 0.512 rs3809863 chr17:45385012 C/T cg25173405 chr17:45401733 C17orf57 -0.42 -5.43 -0.32 1.3e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs8067354 0.830 rs2453913 chr17:57860150 G/T cg02344993 chr17:57696989 CLTC 0.48 6.39 0.37 7.4e-10 Hemoglobin concentration; CESC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg11890956 chr21:40555474 PSMG1 1.0 14.58 0.67 9.62e-36 Cognitive function; CESC cis rs11792861 0.890 rs2900481 chr9:111831825 G/A cg05043794 chr9:111880884 C9orf5 -0.39 -6.39 -0.37 7.25e-10 Menarche (age at onset); CESC cis rs7824557 0.627 rs7838897 chr8:11207326 C/A cg21775007 chr8:11205619 TDH 0.57 8.64 0.47 5.23e-16 Retinal vascular caliber; CESC cis rs3892630 0.878 rs2903759 chr19:33195947 A/G cg13157960 chr19:33183277 NUDT19 0.56 5.46 0.32 1.11e-7 Red blood cell traits; CESC cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC trans rs1814175 0.645 rs28447324 chr11:50046629 C/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.83 -0.76 8.73e-51 Height; CESC cis rs7223966 1.000 rs8069687 chr17:61883023 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.54 -6.6 -0.38 2.26e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7208859 0.623 rs12006 chr17:29110652 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs1728785 0.901 rs11642189 chr16:68583990 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.48 0.42 1.11e-12 Ulcerative colitis; CESC cis rs2066819 1.000 rs41392645 chr12:56696742 A/G cg26714650 chr12:56694279 CS -1.42 -10.05 -0.53 2.39e-20 Psoriasis vulgaris; CESC cis rs78456975 0.527 rs11885279 chr2:1560633 T/C cg12573674 chr2:1569213 NA -0.45 -5.3 -0.31 2.46e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs637571 0.522 rs542332 chr11:65744421 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.56 0.37 2.77e-10 Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17584085 chr17:46688329 HOXB7 -0.55 -6.43 -0.37 6.04e-10 Gut microbiome composition (summer); CESC cis rs793571 0.522 rs11071398 chr15:59120077 A/G cg05156742 chr15:59063176 FAM63B 0.75 10.56 0.54 5.66e-22 Schizophrenia; CESC cis rs67311347 0.955 rs11719205 chr3:40417258 G/A cg09455208 chr3:40491958 NA 0.46 7.93 0.44 6.12e-14 Renal cell carcinoma; CESC cis rs524023 0.958 rs12802649 chr11:64359627 C/T cg07220939 chr11:64358617 SLC22A12 -0.35 -5.39 -0.31 1.54e-7 Urate levels in obese individuals; CESC cis rs6912958 0.712 rs6908386 chr6:88354746 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.71 -0.38 1.19e-10 Monocyte percentage of white cells; CESC cis rs8114671 0.805 rs6060168 chr20:33621017 C/T cg24642439 chr20:33292090 TP53INP2 0.48 6.07 0.35 4.36e-9 Height; CESC cis rs7520050 0.801 rs6703960 chr1:46232723 C/T cg06784218 chr1:46089804 CCDC17 -0.31 -5.59 -0.32 5.66e-8 Red blood cell count;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24488506 chr11:65667952 FOSL1 0.6 7.29 0.41 3.52e-12 Gut microbiome composition (summer); CESC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg22105103 chr4:187893119 NA 0.5 7.32 0.41 2.93e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1559088 1.000 rs11672313 chr19:33563190 C/T cg17764715 chr19:33622953 WDR88 0.45 5.45 0.32 1.18e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs796364 1.000 rs769949 chr2:200729558 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 8.19 0.45 1.12e-14 Schizophrenia; CESC cis rs10504073 0.647 rs62507247 chr8:50013554 T/G cg00325661 chr8:49890786 NA 0.57 8.56 0.47 9.52e-16 Blood metabolite ratios; CESC cis rs61776719 0.520 rs12569027 chr1:38449163 C/T cg04673462 chr1:38461896 NA 0.4 6.06 0.35 4.69e-9 Coronary artery disease; CESC cis rs45535039 1.000 rs6589724 chr11:119112503 G/C cg16724696 chr11:118992527 HINFP 0.43 5.29 0.31 2.51e-7 Plateletcrit; CESC cis rs9896933 0.778 rs80243549 chr17:80821485 G/T cg19500275 chr17:80737654 TBCD 0.61 5.74 0.33 2.63e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs12142240 0.698 rs56049453 chr1:46835468 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.11 0.45 1.85e-14 Menopause (age at onset); CESC cis rs36051895 0.593 rs2094619 chr9:5167712 G/C cg02405213 chr9:5042618 JAK2 -0.46 -5.36 -0.31 1.77e-7 Pediatric autoimmune diseases; CESC cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg03467027 chr4:99064603 C4orf37 0.45 5.61 0.33 4.97e-8 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.837 rs12627667 chr21:45071396 A/C cg04455712 chr21:45112962 RRP1B 0.39 5.84 0.34 1.55e-8 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14481911 chr2:242438436 STK25 -0.58 -6.71 -0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs2073300 0.609 rs6137936 chr20:23385232 C/T cg16736954 chr20:23401023 NAPB 0.8 6.25 0.36 1.67e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7336332 0.598 rs76790205 chr13:28002885 C/T cg01674679 chr13:27998804 GTF3A -0.59 -5.34 -0.31 1.98e-7 Weight; CESC cis rs2952156 0.883 rs907088 chr17:37833567 G/C cg07936489 chr17:37558343 FBXL20 -0.61 -8.1 -0.45 2.03e-14 Asthma; CESC cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg03676636 chr4:99064102 C4orf37 0.34 5.07 0.3 7.65e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18849799 chr19:9929547 FBXL12 0.59 6.98 0.39 2.3e-11 Gut microbiome composition (summer); CESC cis rs9287719 0.839 rs12692415 chr2:10745474 A/G cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC trans rs10751667 0.961 rs6597971 chr11:928598 T/A cg00159523 chr10:114713187 TCF7L2 -0.41 -6.11 -0.35 3.52e-9 Alzheimer's disease (late onset); CESC cis rs7193541 0.684 rs4888262 chr16:74670458 C/T cg01733217 chr16:74700730 RFWD3 1.09 21.98 0.8 1.14e-61 Multiple myeloma; CESC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg21984481 chr17:79567631 NPLOC4 -0.35 -5.41 -0.32 1.43e-7 Eye color traits; CESC trans rs875971 0.577 rs35072105 chr7:65609817 A/G cg26939375 chr7:64535504 NA -0.63 -8.51 -0.46 1.27e-15 Aortic root size; CESC cis rs2559856 1.000 rs2695282 chr12:102089502 A/G cg12213457 chr12:102090980 CHPT1 0.37 5.42 0.32 1.33e-7 Blood protein levels; CESC cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10905065 0.931 rs2497 chr10:5807608 A/G cg11519256 chr10:5708881 ASB13 -0.41 -5.38 -0.31 1.66e-7 Menopause (age at onset); CESC trans rs61931739 0.500 rs11053222 chr12:34481100 C/A cg13010199 chr12:38710504 ALG10B 0.5 6.47 0.37 4.76e-10 Morning vs. evening chronotype; CESC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.04 11.56 0.58 2.63e-25 Platelet count; CESC cis rs8067545 0.562 rs2526481 chr17:20127018 T/C cg13482628 chr17:19912719 NA -0.43 -5.88 -0.34 1.22e-8 Schizophrenia; CESC cis rs13217239 0.646 rs11756275 chr6:27007113 A/C cg12292205 chr6:26970375 C6orf41 -0.5 -7.89 -0.44 7.8e-14 Schizophrenia; CESC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg06873352 chr17:61820015 STRADA 0.72 12.83 0.62 1.2e-29 Prudent dietary pattern; CESC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg22535103 chr8:58192502 C8orf71 -1.06 -13.13 -0.63 1.17e-30 Developmental language disorder (linguistic errors); CESC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg09323728 chr8:95962352 TP53INP1 -0.29 -5.61 -0.33 5.12e-8 Type 2 diabetes; CESC trans rs11098499 0.909 rs28632018 chr4:120386730 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.93 0.52 5.63e-20 Corneal astigmatism; CESC cis rs3008870 0.959 rs2815359 chr1:67494374 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.03 14.0 0.65 1e-33 Lymphocyte percentage of white cells; CESC cis rs9796 0.870 rs28501589 chr15:41282534 G/A cg18705301 chr15:41695430 NDUFAF1 -0.47 -7.09 -0.4 1.23e-11 Menopause (age at onset); CESC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg11890956 chr21:40555474 PSMG1 -0.64 -8.99 -0.48 4.94e-17 Menarche (age at onset); CESC cis rs2652834 0.904 rs2729826 chr15:63360446 C/G cg05507819 chr15:63340323 TPM1 -0.54 -5.51 -0.32 8.55e-8 HDL cholesterol; CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg07092213 chr7:1199455 ZFAND2A -0.43 -5.67 -0.33 3.65e-8 Longevity;Endometriosis; CESC cis rs12983728 0.732 rs34003091 chr19:58662254 T/C cg24884572 chr19:58661833 ZNF329 0.58 5.19 0.3 4.16e-7 Cholesterol, total; CESC cis rs853679 0.882 rs3757188 chr6:28107357 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.77 7.15 0.4 8.61e-12 Depression; CESC cis rs12477438 0.765 rs1054042 chr2:99614396 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.91 -0.48 8.52e-17 Chronic sinus infection; CESC cis rs56104184 0.775 rs73061694 chr19:49399978 T/C cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs6964587 1.000 rs28735847 chr7:91592755 T/C cg17063962 chr7:91808500 NA 0.57 7.81 0.43 1.34e-13 Breast cancer; CESC cis rs2288073 0.801 rs10176347 chr2:24367994 G/A cg20701182 chr2:24300061 SF3B14 0.48 6.06 0.35 4.69e-9 Venous thromboembolism (SNP x SNP interaction); CESC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg24562669 chr7:97807699 LMTK2 0.48 7.1 0.4 1.13e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs77106637 0.769 rs11603313 chr11:72588177 G/A cg03713592 chr11:72463424 ARAP1 1.07 9.62 0.51 5.53e-19 Type 2 diabetes; CESC cis rs12142240 0.698 rs17361805 chr1:46813967 C/T cg00530320 chr1:46809349 NSUN4 0.57 7.73 0.43 2.19e-13 Menopause (age at onset); CESC cis rs2742234 0.590 rs2742237 chr10:43621323 C/G cg15436174 chr10:43711423 RASGEF1A -0.47 -5.44 -0.32 1.22e-7 Hirschsprung disease; CESC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg23281280 chr6:28129359 ZNF389 0.56 7.62 0.42 4.55e-13 Depression; CESC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg22903657 chr4:1355424 KIAA1530 -0.38 -5.18 -0.3 4.5e-7 Obesity-related traits; CESC cis rs709400 1.000 rs8018979 chr14:104109087 G/A cg12935359 chr14:103987150 CKB -0.44 -6.01 -0.35 6.1e-9 Body mass index; CESC cis rs36051895 0.632 rs10974982 chr9:5149382 G/C cg02405213 chr9:5042618 JAK2 -0.51 -6.4 -0.37 6.99e-10 Pediatric autoimmune diseases; CESC cis rs10838687 0.800 rs10769253 chr11:47362339 G/A cg25783544 chr11:47291846 MADD 0.57 6.38 0.36 7.81e-10 Proinsulin levels; CESC cis rs7188697 0.922 rs9926577 chr16:58613431 C/T cg02549819 chr16:58548995 SETD6 0.44 5.43 0.32 1.26e-7 QT interval; CESC cis rs7914558 1.000 rs4917994 chr10:104811699 C/T cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.49e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs3733585 0.673 rs4312757 chr4:9956145 T/A cg00071950 chr4:10020882 SLC2A9 -0.7 -11.52 -0.58 3.7e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11229555 1.000 rs11229555 chr11:58408687 G/T cg15696309 chr11:58395628 NA -0.44 -5.62 -0.33 4.88e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27607639 chr17:26879503 UNC119 0.6 6.62 0.38 2.02e-10 Gut microbiome composition (summer); CESC cis rs425277 1.000 rs425277 chr1:2069172 C/T cg24578937 chr1:2090814 PRKCZ 0.54 9.07 0.49 2.73e-17 Height; CESC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg01448562 chr3:133502909 NA -0.42 -5.9 -0.34 1.09e-8 Iron status biomarkers; CESC cis rs1005277 0.505 rs7069702 chr10:38247359 G/T cg25427524 chr10:38739819 LOC399744 0.71 10.67 0.55 2.36e-22 Extrinsic epigenetic age acceleration; CESC cis rs1552244 0.554 rs17050704 chr3:10045734 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -7.17 -0.4 7.49e-12 Alzheimer's disease; CESC cis rs12618769 0.652 rs3769708 chr2:99187650 T/C cg10123293 chr2:99228465 UNC50 0.41 5.34 0.31 2e-7 Bipolar disorder; CESC trans rs6089829 0.962 rs9680064 chr20:61666168 G/A cg23505145 chr19:12996616 KLF1 0.52 6.8 0.39 6.85e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs4076764 0.914 rs10753614 chr1:163365903 C/T cg24596788 chr1:163392923 NA 0.51 7.51 0.42 8.8e-13 Motion sickness; CESC cis rs6120849 0.754 rs6120819 chr20:33653038 T/C cg24642439 chr20:33292090 TP53INP2 0.67 6.67 0.38 1.51e-10 Protein C levels; CESC cis rs3105593 1.000 rs934624 chr15:50968906 A/C cg08437265 chr15:50716283 USP8 0.47 6.16 0.35 2.7e-9 QT interval; CESC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.75e-12 Tonsillectomy; CESC cis rs56046484 0.956 rs35533990 chr15:85664821 G/C cg08123816 chr15:85640762 PDE8A -0.5 -6.19 -0.36 2.23e-9 Testicular germ cell tumor; CESC cis rs10089 1.000 rs62373701 chr5:127416294 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.77 10.09 0.53 1.76e-20 Ileal carcinoids; CESC trans rs877282 0.947 rs7923867 chr10:768094 G/A cg22713356 chr15:30763199 NA 1.16 11.7 0.58 9.33e-26 Uric acid levels; CESC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg26343298 chr8:95960752 TP53INP1 0.34 5.55 0.32 6.76e-8 Type 2 diabetes; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg13479780 chr6:41909532 CCND3 -0.41 -6.0 -0.35 6.6e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs4319547 0.915 rs10773208 chr12:122970156 T/C cg05707623 chr12:122985044 ZCCHC8 -0.66 -7.6 -0.42 5.09e-13 Body mass index; CESC cis rs17666538 0.642 rs7821983 chr8:643696 A/G cg07685180 chr8:600429 NA 0.59 5.13 0.3 5.5e-7 IgG glycosylation; CESC cis rs7078219 0.505 rs1548964 chr10:101289653 C/G cg09788492 chr10:101292477 NKX2-3 -0.33 -6.2 -0.36 2.18e-9 Dental caries; CESC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg11644478 chr21:40555479 PSMG1 -0.56 -7.58 -0.42 5.83e-13 Menarche (age at onset); CESC cis rs6701037 1.000 rs6677097 chr1:175123897 C/G cg00321850 chr1:175162397 KIAA0040 -0.41 -5.85 -0.34 1.42e-8 Alcohol dependence; CESC trans rs1478897 0.575 rs12679960 chr8:11430990 C/T cg15556689 chr8:8085844 FLJ10661 0.58 6.59 0.38 2.32e-10 Systemic lupus erythematosus; CESC cis rs3026101 0.624 rs11869800 chr17:5307781 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs6120849 0.663 rs13041792 chr20:33545055 G/A cg24642439 chr20:33292090 TP53INP2 0.69 6.83 0.39 5.9e-11 Protein C levels; CESC cis rs7208859 0.623 rs8067035 chr17:29102188 T/C cg19761014 chr17:28927070 LRRC37B2 0.73 6.16 0.35 2.71e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2625529 0.730 rs8182011 chr15:72389948 C/T cg16672083 chr15:72433130 SENP8 0.44 6.25 0.36 1.67e-9 Red blood cell count; CESC cis rs6582630 0.502 rs1607876 chr12:38355750 T/C cg26384229 chr12:38710491 ALG10B 0.69 10.42 0.54 1.6e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs9894429 0.646 rs9905639 chr17:79614154 A/G cg18240062 chr17:79603768 NPLOC4 0.51 6.62 0.38 1.98e-10 Eye color traits; CESC cis rs12410462 0.681 rs115959512 chr1:227599578 T/C cg23173402 chr1:227635558 NA 0.72 5.75 0.33 2.41e-8 Major depressive disorder; CESC cis rs2180341 0.960 rs9401952 chr6:127677027 A/C cg24812749 chr6:127587940 RNF146 1.05 15.15 0.68 9.37e-38 Breast cancer; CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.48 6.34 0.36 9.77e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7520050 0.966 rs7524495 chr1:46266932 T/C cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.38e-7 Red blood cell count;Reticulocyte count; CESC cis rs1847202 0.517 rs13062803 chr3:72951840 T/A cg25664220 chr3:72788482 NA -0.38 -5.56 -0.32 6.53e-8 Motion sickness; CESC cis rs7829975 0.511 rs2976906 chr8:8342415 A/T cg15556689 chr8:8085844 FLJ10661 0.53 6.45 0.37 5.2e-10 Mood instability; CESC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg22963979 chr7:1858916 MAD1L1 -0.43 -5.88 -0.34 1.25e-8 Bipolar disorder and schizophrenia; CESC trans rs34421088 0.560 rs2248316 chr8:11397073 A/C cg15556689 chr8:8085844 FLJ10661 -0.51 -6.0 -0.35 6.33e-9 Neuroticism; CESC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg13918804 chr1:2043761 PRKCZ 0.28 5.07 0.3 7.45e-7 Height; CESC trans rs12310956 0.532 rs1589903 chr12:33943019 C/T cg26384229 chr12:38710491 ALG10B 0.59 8.27 0.45 6.51e-15 Morning vs. evening chronotype; CESC cis rs4727027 0.870 rs13237714 chr7:148884083 A/G cg23158103 chr7:148848205 ZNF398 -0.41 -6.57 -0.37 2.71e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg07507251 chr3:52567010 NT5DC2 0.42 7.2 0.4 6.23e-12 Bipolar disorder; CESC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg18230493 chr5:56204884 C5orf35 -0.7 -8.22 -0.45 9.11e-15 Initial pursuit acceleration; CESC cis rs6570726 0.791 rs6902410 chr6:145905261 G/A cg05347473 chr6:146136440 FBXO30 0.59 7.62 0.42 4.47e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs9303280 0.806 rs34189114 chr17:38032460 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.42 -0.32 1.34e-7 Self-reported allergy; CESC cis rs17376456 1.000 rs34013242 chr5:93507947 C/T cg21475434 chr5:93447410 FAM172A 0.87 7.69 0.43 2.86e-13 Diabetic retinopathy; CESC cis rs7296418 0.636 rs11057261 chr12:123797567 T/C cg00376283 chr12:123451042 ABCB9 0.57 7.68 0.43 3e-13 Platelet count; CESC cis rs2228479 0.850 rs17227057 chr16:89816333 C/T cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg25405998 chr7:65216604 CCT6P1 -0.47 -5.25 -0.31 3.14e-7 Aortic root size; CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg06877462 chr1:205807181 PM20D1 0.44 6.74 0.38 9.9e-11 Menarche (age at onset); CESC cis rs6748734 1.000 rs6751693 chr2:241837332 T/C cg04034577 chr2:241836375 C2orf54 -0.5 -8.55 -0.47 9.66e-16 Urinary metabolites; CESC cis rs6424115 0.830 rs4649124 chr1:24201357 A/G cg10978503 chr1:24200527 CNR2 0.33 6.64 0.38 1.73e-10 Immature fraction of reticulocytes; CESC cis rs10751667 0.666 rs7943140 chr11:973824 T/C cg06064525 chr11:970664 AP2A2 -0.46 -8.92 -0.48 7.68e-17 Alzheimer's disease (late onset); CESC cis rs853679 0.824 rs1321505 chr6:28052823 A/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.79 6.72 0.38 1.1e-10 Depression; CESC cis rs10883723 0.773 rs2296578 chr10:104240974 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.56 7.66 0.43 3.52e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs1499614 1.000 rs2707830 chr7:66167645 T/C cg12463550 chr7:65579703 CRCP 0.73 5.73 0.33 2.78e-8 Gout; CESC cis rs9291683 0.588 rs34501273 chr4:9996996 C/T cg02734326 chr4:10020555 SLC2A9 0.49 7.14 0.4 8.74e-12 Bone mineral density; CESC cis rs2806561 0.734 rs2143156 chr1:23374629 T/G cg12483005 chr1:23474871 LUZP1 0.34 5.26 0.31 2.9e-7 Height; CESC cis rs1045902 0.574 rs1474298 chr2:73466592 C/T cg01422370 chr2:73384389 NA 0.39 5.42 0.32 1.35e-7 Intelligence (multi-trait analysis); CESC cis rs1953600 0.870 rs2789690 chr10:81938204 G/T cg00277334 chr10:82204260 NA 0.45 6.28 0.36 1.39e-9 Sarcoidosis; CESC cis rs1153858 1.000 rs4271549 chr15:45652730 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.97 0.34 7.62e-9 Homoarginine levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08125682 chr16:11038455 CLEC16A 0.5 6.88 0.39 4.39e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11098499 0.820 rs13128602 chr4:120459366 C/T cg24375607 chr4:120327624 NA -0.43 -5.34 -0.31 1.96e-7 Corneal astigmatism; CESC cis rs11428934 1 rs11428934 chr19:49144245 T/TG cg06677660 chr19:49140777 SEC1;DBP 0.44 5.18 0.3 4.44e-7 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Granulocyte count; CESC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs17253792 0.822 rs74412558 chr14:56054311 C/T cg01858014 chr14:56050164 KTN1 -0.97 -7.15 -0.4 8.64e-12 Putamen volume; CESC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg18876405 chr7:65276391 NA 0.54 7.59 0.42 5.49e-13 Aortic root size; CESC cis rs1499614 1.000 rs2659911 chr7:66158420 G/A cg18252515 chr7:66147081 NA -1.42 -14.62 -0.67 6.69e-36 Gout; CESC cis rs6831352 0.918 rs34876213 chr4:100062216 G/A cg12011299 chr4:100065546 ADH4 -0.59 -6.48 -0.37 4.49e-10 Alcohol dependence; CESC cis rs9929218 1.000 rs2113200 chr16:68814948 A/T cg02972257 chr16:68554789 NA 0.48 5.74 0.33 2.61e-8 Colorectal cancer; CESC cis rs12530845 0.945 rs12540273 chr7:135333854 T/G cg23117316 chr7:135346802 PL-5283 -0.4 -5.15 -0.3 5.07e-7 Red blood cell traits; CESC cis rs116095464 0.614 rs56299325 chr5:220594 C/T cg22496380 chr5:211416 CCDC127 -0.72 -8.57 -0.47 8.59e-16 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09356014 chr16:87380193 FBXO31 -0.65 -7.2 -0.4 6.18e-12 Gut microbiome composition (summer); CESC cis rs6570726 0.935 rs368848 chr6:145855281 A/T cg05347473 chr6:146136440 FBXO30 0.48 6.47 0.37 4.82e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6460942 0.915 rs17444044 chr7:12458736 A/G cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.43 5.58 0.32 5.83e-8 Bipolar disorder; CESC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.16e-7 Aortic root size; CESC cis rs9911578 0.967 rs12938821 chr17:56959422 T/C cg12560992 chr17:57184187 TRIM37 0.94 15.4 0.69 1.19e-38 Intelligence (multi-trait analysis); CESC cis rs6723226 0.961 rs13010404 chr2:32848854 T/G cg02381751 chr2:32503542 YIPF4 -0.7 -9.33 -0.5 4.32e-18 Intelligence (multi-trait analysis); CESC cis rs6740322 0.948 rs6722694 chr2:43569798 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.59 -6.44 -0.37 5.65e-10 Coronary artery disease; CESC cis rs9309473 1.000 rs6546838 chr2:73679280 A/G cg20560298 chr2:73613845 ALMS1 -0.46 -6.17 -0.35 2.53e-9 Metabolite levels; CESC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg04546413 chr19:29218101 NA 0.48 7.8 0.43 1.38e-13 Methadone dose in opioid dependence; CESC cis rs1443512 0.812 rs2044210 chr12:54335533 C/G cg17410650 chr12:54324560 NA -0.46 -7.97 -0.44 4.81e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs7772486 0.875 rs2777484 chr6:146334162 A/G cg05347473 chr6:146136440 FBXO30 0.47 6.16 0.35 2.63e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs11030122 0.702 rs10835406 chr11:3992954 G/T cg18678763 chr11:4115507 RRM1 0.52 6.95 0.39 2.82e-11 Mean platelet volume;Platelet distribution width; CESC cis rs965469 0.545 rs6051845 chr20:3402792 A/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.82 -0.34 1.69e-8 IFN-related cytopenia; CESC cis rs644799 1.000 rs580255 chr11:95577929 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.94 13.87 0.65 3.02e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1577917 1.000 rs12212733 chr6:86726013 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.15 -0.35 2.89e-9 Response to antipsychotic treatment; CESC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg24531977 chr5:56204891 C5orf35 0.46 5.41 0.32 1.42e-7 Coronary artery disease; CESC cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg19077165 chr18:44547161 KATNAL2 -0.54 -7.93 -0.44 6.3e-14 Personality dimensions; CESC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.68 -0.33 3.49e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg08859206 chr1:53392774 SCP2 -0.64 -8.55 -0.47 9.9e-16 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08262505 chr5:32174500 GOLPH3 0.63 6.93 0.39 3.12e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17481046 chr3:40547578 ZNF620 0.57 6.68 0.38 1.38e-10 Gut microbiome composition (summer); CESC cis rs27434 0.561 rs151910 chr5:96156956 C/A cg16492584 chr5:96139282 ERAP1 -0.36 -5.09 -0.3 6.81e-7 Ankylosing spondylitis; CESC cis rs3020736 0.500 rs4147640 chr22:42485292 T/C cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC cis rs2573652 1.000 rs2581346 chr15:100514178 T/G cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.44 -0.32 1.21e-7 Height; CESC cis rs796364 0.806 rs12619136 chr2:200910347 C/A cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC cis rs698833 0.926 rs1085449 chr2:44653432 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.83 0.34 1.6e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs523522 0.962 rs10849759 chr12:120994488 T/A cg27279351 chr12:120934652 DYNLL1 0.68 8.78 0.47 2.09e-16 High light scatter reticulocyte count; CESC cis rs896854 0.517 rs9643353 chr8:95957063 A/G cg09323728 chr8:95962352 TP53INP1 0.38 7.42 0.41 1.6e-12 Type 2 diabetes; CESC cis rs7666738 0.519 rs11732209 chr4:98801643 A/G cg05340658 chr4:99064831 C4orf37 0.54 6.58 0.37 2.49e-10 Colonoscopy-negative controls vs population controls; CESC cis rs62408225 0.894 rs17585295 chr6:90944831 C/T cg06866423 chr6:90926672 BACH2 0.43 5.32 0.31 2.23e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22902478 chr11:67085251 LOC100130987 0.61 7.4 0.41 1.83e-12 Gut microbiome composition (summer); CESC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg06873352 chr17:61820015 STRADA 0.72 12.45 0.61 2.58e-28 Prudent dietary pattern; CESC cis rs17431357 1.000 rs73225248 chr12:120971517 G/C cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC trans rs61931739 0.534 rs4001713 chr12:34154195 A/C cg13010199 chr12:38710504 ALG10B -0.49 -6.21 -0.36 2e-9 Morning vs. evening chronotype; CESC cis rs7918232 0.882 rs788211 chr10:27479070 C/T cg14240646 chr10:27532245 ACBD5 0.67 6.59 0.38 2.41e-10 Breast cancer; CESC cis rs60154123 0.772 rs845452 chr1:210417861 C/T cg23283495 chr1:209979779 IRF6 0.45 5.45 0.32 1.14e-7 Coronary artery disease; CESC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg23985595 chr17:80112537 CCDC57 0.41 6.44 0.37 5.45e-10 Life satisfaction; CESC cis rs10979 0.597 rs9403516 chr6:143908139 A/T cg25407410 chr6:143891975 LOC285740 0.44 5.38 0.31 1.66e-7 Hypospadias; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg08437789 chr10:135085344 ADAM8 -0.43 -6.25 -0.36 1.63e-9 Psoriatic arthritis; CESC cis rs7829975 0.714 rs59046059 chr8:8670736 C/A cg06636001 chr8:8085503 FLJ10661 0.43 5.65 0.33 4.2e-8 Mood instability; CESC cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg11812906 chr14:75593930 NEK9 0.84 13.72 0.64 1.02e-32 Height; CESC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg27170947 chr2:26402098 FAM59B 0.57 7.04 0.4 1.67e-11 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg12963246 chr6:28129442 ZNF389 0.58 7.62 0.42 4.61e-13 Depression; CESC cis rs677665 0.918 rs11590326 chr1:9339205 A/G cg25755851 chr1:9335794 NA -0.64 -8.15 -0.45 1.43e-14 Eosinophil percentage of white cells; CESC cis rs3820068 0.705 rs2042369 chr1:15843244 A/G cg17385448 chr1:15911702 AGMAT -0.35 -5.54 -0.32 7.19e-8 Systolic blood pressure; CESC trans rs2727020 0.675 rs1684258 chr11:49340020 G/A cg15704280 chr7:45808275 SEPT13 0.77 8.92 0.48 7.85e-17 Coronary artery disease; CESC cis rs6076065 0.748 rs2253834 chr20:23387816 C/T cg11657817 chr20:23433608 CST11 -0.38 -5.86 -0.34 1.38e-8 Facial morphology (factor 15, philtrum width); CESC cis rs6831352 0.819 rs2851274 chr4:100025866 G/C cg21548116 chr4:100009993 ADH5 0.46 5.06 0.3 7.69e-7 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27060912 chr19:6517005 NA 0.52 6.55 0.37 2.95e-10 Gut microbiome composition (summer); CESC cis rs7927771 0.524 rs7929725 chr11:47881740 A/G cg18512352 chr11:47633146 NA 0.35 5.41 0.32 1.44e-7 Subjective well-being; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07287463 chr1:47903450 FOXD2 -0.46 -6.05 -0.35 5.01e-9 Asthma; CESC cis rs2243480 1.000 rs35542501 chr7:65431215 T/C cg12463550 chr7:65579703 CRCP 0.68 5.63 0.33 4.55e-8 Diabetic kidney disease; CESC cis rs62064224 0.589 rs2041306 chr17:30665675 T/C cg18200150 chr17:30822561 MYO1D 0.4 5.11 0.3 6.19e-7 Schizophrenia; CESC cis rs7212590 0.655 rs8070039 chr17:57973585 G/C cg20303301 chr17:57937339 TUBD1 -0.55 -5.46 -0.32 1.08e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05020822 chr8:144373356 ZNF696 0.63 7.64 0.42 4.04e-13 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17157516 chr1:35332203 DLGAP3 0.47 6.58 0.37 2.55e-10 Systemic lupus erythematosus; CESC cis rs4253772 0.513 rs11090863 chr22:46705407 C/T cg24881330 chr22:46731750 TRMU 0.75 5.72 0.33 2.81e-8 LDL cholesterol;Cholesterol, total; CESC cis rs62064224 0.702 rs2302277 chr17:30791509 C/G cg09324608 chr17:30823087 MYO1D 0.52 8.05 0.44 2.88e-14 Schizophrenia; CESC cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg26874164 chr19:58962979 ZNF324B 0.54 7.57 0.42 6.14e-13 Uric acid clearance; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26824326 chr1:9664366 TMEM201 -0.71 -7.87 -0.44 8.85e-14 Gut microbiome composition (summer); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg22622495 chr1:91966418 CDC7 0.46 6.41 0.37 6.58e-10 Bronchopulmonary dysplasia; CESC cis rs8177253 0.511 rs9830001 chr3:133433470 A/G cg16262614 chr3:133464971 TF -0.3 -5.45 -0.32 1.16e-7 Iron status biomarkers; CESC cis rs1348850 0.914 rs1453370 chr2:178327727 C/T cg22681709 chr2:178499509 PDE11A -0.42 -6.02 -0.35 5.67e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7188697 0.922 rs246196 chr16:58574253 T/C cg02549819 chr16:58548995 SETD6 -0.42 -5.3 -0.31 2.46e-7 QT interval; CESC cis rs79839061 0.610 rs17781499 chr4:889384 C/A cg07828340 chr4:882639 GAK 1.07 8.32 0.46 4.68e-15 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs10883723 0.810 rs7069356 chr10:104254359 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg26335602 chr6:28129616 ZNF389 0.48 6.06 0.35 4.7e-9 Parkinson's disease; CESC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg26304593 chr6:42947056 PEX6 -0.43 -5.58 -0.32 5.92e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7084402 0.967 rs1649065 chr10:60306386 T/G cg07615347 chr10:60278583 BICC1 0.59 9.34 0.5 4.23e-18 Refractive error; CESC cis rs116095464 0.614 rs4371799 chr5:268192 C/A cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.31 0.31 2.37e-7 Breast cancer; CESC cis rs7091068 0.536 rs7893369 chr10:95410147 A/G cg20715218 chr10:95462985 C10orf4 0.46 5.66 0.33 3.85e-8 Urinary tract infection frequency; CESC cis rs1153858 1.000 rs1346268 chr15:45673029 T/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs611744 0.647 rs7016198 chr8:109262752 G/A cg21045802 chr8:109455806 TTC35 0.46 5.7 0.33 3.13e-8 Dupuytren's disease; CESC trans rs3780486 0.801 rs10971424 chr9:33138775 T/C cg20290983 chr6:43655470 MRPS18A 0.99 18.43 0.75 2.16e-49 IgG glycosylation; CESC cis rs9796 0.689 rs13329537 chr15:41449211 C/G cg18705301 chr15:41695430 NDUFAF1 0.46 6.93 0.39 3.27e-11 Menopause (age at onset); CESC cis rs7223966 1.000 rs61360320 chr17:61800392 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.68 0.38 1.39e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs17253792 0.822 rs74935793 chr14:56143277 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs2806561 0.704 rs2868573 chr1:23508253 C/G cg12483005 chr1:23474871 LUZP1 0.39 6.06 0.35 4.58e-9 Height; CESC cis rs7998202 0.667 rs914016 chr13:113355057 A/C cg02820901 chr13:113351484 ATP11A 0.65 5.78 0.33 2.05e-8 Glycated hemoglobin levels; CESC cis rs4888262 0.545 rs36097721 chr16:74648267 C/G cg01733217 chr16:74700730 RFWD3 0.87 12.3 0.6 8.07e-28 Testicular germ cell tumor; CESC cis rs8060686 0.641 rs113896227 chr16:68101480 C/T cg26727032 chr16:67993705 SLC12A4 -0.54 -6.06 -0.35 4.73e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg06484146 chr7:12443880 VWDE -0.75 -8.83 -0.48 1.48e-16 Coronary artery disease; CESC trans rs9329221 0.537 rs12678797 chr8:9978919 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.14 -0.35 3.03e-9 Neuroticism; CESC cis rs2637266 1.000 rs7080883 chr10:78361200 A/G cg18941641 chr10:78392320 NA 0.41 7.89 0.44 7.84e-14 Pulmonary function; CESC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg25767906 chr1:53392781 SCP2 0.53 7.63 0.42 4.32e-13 Monocyte count; CESC cis rs8066384 1 rs8066384 chr17:78625756 T/C cg09596252 chr17:78655493 RPTOR 0.42 5.09 0.3 6.68e-7 Schizophrenia; CESC cis rs9611519 0.929 rs4820423 chr22:41430338 A/T cg03806693 chr22:41940476 POLR3H -0.57 -5.94 -0.34 9.05e-9 Neuroticism; CESC cis rs6867032 0.527 rs4246752 chr5:1975575 T/A cg26168224 chr5:2018326 NA -0.79 -11.67 -0.58 1.13e-25 Gut microbiome composition (winter); CESC cis rs3008870 0.755 rs3929738 chr1:67397865 T/C cg02640540 chr1:67518911 SLC35D1 0.46 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs3741151 0.773 rs73542979 chr11:73127526 G/C cg17517138 chr11:73019481 ARHGEF17 0.94 6.86 0.39 4.87e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg25405998 chr7:65216604 CCT6P1 0.46 5.42 0.32 1.37e-7 Aortic root size; CESC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 5.87 0.34 1.27e-8 Personality dimensions; CESC cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9354308 0.866 rs2802054 chr6:66544766 G/C cg07460842 chr6:66804631 NA 0.58 6.53 0.37 3.29e-10 Metabolite levels; CESC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.07 -0.4 1.36e-11 Gut microbiome composition (summer); CESC cis rs9309473 1.000 rs7598419 chr2:73798223 A/G cg20560298 chr2:73613845 ALMS1 -0.55 -6.91 -0.39 3.61e-11 Metabolite levels; CESC cis rs1799949 0.965 rs4793234 chr17:41436183 A/G cg05368731 chr17:41323189 NBR1 0.75 10.33 0.54 3.04e-21 Menopause (age at onset); CESC cis rs34779708 0.966 rs4294520 chr10:35422506 C/T cg04310649 chr10:35416472 CREM -0.49 -5.83 -0.34 1.63e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg12648201 chr2:27665141 KRTCAP3 -0.33 -6.1 -0.35 3.76e-9 Total body bone mineral density; CESC cis rs9549260 0.640 rs4943796 chr13:41196016 C/T cg21288729 chr13:41239152 FOXO1 0.62 7.9 0.44 7.34e-14 Red blood cell count; CESC cis rs854765 0.547 rs8075189 chr17:17901946 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.54 7.72 0.43 2.32e-13 Total body bone mineral density; CESC cis rs9447004 0.584 rs12215671 chr6:74435607 T/C cg23004174 chr6:74404879 CD109 0.36 5.06 0.3 7.8e-7 Blood protein levels;Calcium levels; CESC cis rs112790992 1 rs112790992 chr14:105758217 A/C cg10792982 chr14:105748885 BRF1 0.37 5.13 0.3 5.48e-7 Platelet count; CESC cis rs11048434 0.723 rs1805737 chr12:9084670 A/T cg04155231 chr12:9217510 LOC144571 0.32 5.13 0.3 5.61e-7 Sjögren's syndrome; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg12282830 chr22:29784441 AP1B1 -0.49 -6.18 -0.35 2.39e-9 Recombination measurement; CESC cis rs6540559 0.673 rs41305104 chr1:209950848 G/A cg21951975 chr1:209979733 IRF6 0.54 6.37 0.36 8.44e-10 Cleft lip with or without cleft palate; CESC cis rs4713675 0.584 rs7759668 chr6:33670406 C/T cg15676125 chr6:33679581 C6orf125 -0.34 -5.04 -0.3 8.45e-7 Plateletcrit; CESC cis rs3733585 0.631 rs3822236 chr4:10119961 T/G cg05927159 chr4:10118984 WDR1 0.34 5.08 0.3 7.04e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -8.18 -0.45 1.19e-14 Developmental language disorder (linguistic errors); CESC trans rs4498364 0.541 rs1206154 chr6:97548919 G/A cg09636063 chr6:158957850 TMEM181 0.43 6.07 0.35 4.47e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs17209837 1.000 rs45593435 chr7:87088772 A/G cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC trans rs1814175 0.645 rs1721997 chr11:49916653 T/C cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs1568889 1.000 rs61889046 chr11:28297024 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.82 11.86 0.59 2.68e-26 Bipolar disorder; CESC cis rs6977955 1.000 rs4722762 chr7:28178262 G/T cg23620719 chr7:28220237 JAZF1 0.61 6.74 0.38 9.96e-11 Allergic disease (asthma, hay fever or eczema); CESC cis rs2880765 0.805 rs11858817 chr15:86031260 C/T cg10818794 chr15:86012489 AKAP13 -0.35 -5.42 -0.32 1.32e-7 Coronary artery disease; CESC cis rs7507204 0.723 rs12982194 chr19:3411947 G/A cg08380311 chr19:3435252 NFIC 0.62 6.61 0.38 2.13e-10 Height; CESC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg11301795 chr4:187892539 NA -0.75 -12.03 -0.59 6.89e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs752010 0.806 rs11210500 chr1:42089737 A/G cg06885757 chr1:42089581 HIVEP3 0.53 9.11 0.49 2.04e-17 Lupus nephritis in systemic lupus erythematosus; CESC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg10792982 chr14:105748885 BRF1 0.39 5.04 0.3 8.62e-7 Mean platelet volume;Platelet distribution width; CESC cis rs1348850 0.574 rs4893834 chr2:178442288 C/T cg22681709 chr2:178499509 PDE11A 0.45 5.26 0.31 3.02e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg11247378 chr22:39784982 NA -0.62 -8.34 -0.46 4.13e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs6690583 0.623 rs2083283 chr1:85439996 C/A cg22153463 chr1:85462885 MCOLN2 0.75 7.31 0.41 3.25e-12 Serum sulfate level; CESC cis rs4925386 1.000 rs2151512 chr20:60913495 T/C cg24112000 chr20:60950667 NA 0.52 7.71 0.43 2.62e-13 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs10392 0.543 rs57569873 chr20:37558293 T/C cg27552599 chr20:37590471 DHX35 0.39 5.88 0.34 1.23e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs909674 0.515 rs9611170 chr22:39784845 G/C cg11247378 chr22:39784982 NA -0.67 -10.28 -0.53 4.34e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs6496667 0.779 rs28516870 chr15:91037754 G/A cg13834112 chr15:90361639 NA 0.4 5.29 0.31 2.56e-7 Rheumatoid arthritis; CESC cis rs12188164 0.515 rs11745246 chr5:410943 A/G cg26850624 chr5:429559 AHRR -0.42 -5.43 -0.32 1.26e-7 Cystic fibrosis severity; CESC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg04315214 chr1:2043799 PRKCZ 0.54 9.25 0.49 7.68e-18 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17165990 chr19:19656778 CILP2 0.47 6.51 0.37 3.8e-10 Fibrinogen levels; CESC cis rs1448094 0.545 rs11117077 chr12:86277317 A/G cg02569458 chr12:86230093 RASSF9 0.42 6.14 0.35 3.03e-9 Major depressive disorder; CESC cis rs3020736 0.500 rs2839708 chr22:42500745 A/G cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg20790798 chr5:1857306 NA -0.41 -5.39 -0.31 1.59e-7 Cardiovascular disease risk factors; CESC cis rs12824058 0.831 rs12831363 chr12:130814013 C/T cg23887609 chr12:130822674 PIWIL1 -0.44 -5.75 -0.33 2.39e-8 Menopause (age at onset); CESC cis rs6570726 0.791 rs6570692 chr6:145904401 T/A cg05347473 chr6:146136440 FBXO30 0.59 7.61 0.42 4.67e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs4927850 0.752 rs7618864 chr3:195749561 G/A cg16724585 chr3:197361211 NA -0.56 -7.19 -0.4 6.66e-12 Pancreatic cancer; CESC cis rs4975709 0.569 rs931509 chr5:1858821 A/T cg14773178 chr5:1868261 NA 0.32 5.44 0.32 1.19e-7 Cardiovascular disease risk factors; CESC cis rs11122272 0.735 rs2749714 chr1:231538634 G/C cg06096015 chr1:231504339 EGLN1 0.42 6.05 0.35 4.97e-9 Hemoglobin concentration; CESC cis rs3091242 0.933 rs28633797 chr1:25741629 C/A cg03538708 chr1:25844672 NA -0.41 -6.17 -0.35 2.6e-9 Erythrocyte sedimentation rate; CESC cis rs8114671 0.562 rs1801310 chr20:33517014 A/G cg07148914 chr20:33460835 GGT7 0.52 6.8 0.39 6.88e-11 Height; CESC cis rs116095464 0.558 rs10079760 chr5:230778 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.49 0.32 9.64e-8 Breast cancer; CESC cis rs2243480 1.000 rs35825738 chr7:65318027 A/G cg18252515 chr7:66147081 NA -1.01 -9.73 -0.51 2.51e-19 Diabetic kidney disease; CESC cis rs10504229 0.817 rs58957714 chr8:58195864 G/A cg14926445 chr8:58193284 C8orf71 -0.6 -5.73 -0.33 2.73e-8 Developmental language disorder (linguistic errors); CESC cis rs60871478 0.945 rs4719279 chr7:813618 T/C cg27478167 chr7:817139 HEATR2 -0.45 -5.23 -0.31 3.47e-7 Cerebrospinal P-tau181p levels; CESC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.76 10.65 0.55 2.74e-22 Prudent dietary pattern; CESC trans rs3780486 0.846 rs10113903 chr9:33122645 C/G cg04842962 chr6:43655489 MRPS18A -1.01 -19.55 -0.77 2.63e-53 IgG glycosylation; CESC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg01411255 chr17:61851458 DDX42;CCDC47 -1.08 -18.78 -0.76 1.28e-50 Height; CESC cis rs1215050 0.740 rs2555390 chr4:98999112 A/G cg17366294 chr4:99064904 C4orf37 -0.39 -5.17 -0.3 4.59e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg01238044 chr22:24384105 GSTT1 -0.63 -8.29 -0.45 5.65e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 2e-28 Colonoscopy-negative controls vs population controls; CESC cis rs8141529 0.748 rs5997412 chr22:29276747 G/A cg02153584 chr22:29168773 CCDC117 0.59 7.61 0.42 4.72e-13 Lymphocyte counts; CESC cis rs3096299 0.748 rs3102339 chr16:89442711 C/T cg08392591 chr16:89556376 ANKRD11 0.43 5.42 0.32 1.31e-7 Multiple myeloma (IgH translocation); CESC cis rs113835537 0.529 rs4542420 chr11:66277610 G/C cg24851651 chr11:66362959 CCS 0.44 5.46 0.32 1.11e-7 Airway imaging phenotypes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg11948252 chr1:160771900 LY9 -0.4 -6.31 -0.36 1.18e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs12681287 0.547 rs7461366 chr8:87511685 C/T cg27317242 chr8:23145699 R3HCC1 -0.53 -6.34 -0.36 9.67e-10 Caudate activity during reward; CESC cis rs11122272 0.735 rs2808600 chr1:231534723 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13216351 chr20:49575105 MOCS3;DPM1 0.58 6.96 0.39 2.7e-11 Gut microbiome composition (summer); CESC cis rs425277 0.527 rs3107144 chr1:2045380 C/A cg23803603 chr1:2058230 PRKCZ -0.35 -6.12 -0.35 3.38e-9 Height; CESC cis rs6060717 0.536 rs17432470 chr20:34547763 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 5.24 0.31 3.33e-7 Hip circumference adjusted for BMI; CESC cis rs4722166 0.532 rs6461662 chr7:22757089 C/T cg05472934 chr7:22766657 IL6 0.51 6.87 0.39 4.7e-11 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19262334 chr18:74631861 ZNF236 0.48 6.3 0.36 1.2e-9 Fibrinogen levels; CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.48 6.37 0.36 8.55e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.83 8.32 0.46 4.57e-15 Platelet count; CESC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg08470875 chr2:26401718 FAM59B -0.73 -7.98 -0.44 4.43e-14 Gut microbiome composition (summer); CESC trans rs10506458 1.000 rs12425932 chr12:63410497 C/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.36 -18.93 -0.76 3.88e-51 Hemostatic factors and hematological phenotypes; CESC cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.547 rs12150369 chr17:17911014 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.54 7.72 0.43 2.32e-13 Total body bone mineral density; CESC cis rs7937682 0.883 rs1613778 chr11:111456105 G/C cg22437258 chr11:111473054 SIK2 0.71 9.1 0.49 2.27e-17 Primary sclerosing cholangitis; CESC cis rs9393777 0.623 rs3757150 chr6:26476782 T/A cg14345882 chr6:26364793 BTN3A2 0.43 5.34 0.31 2.01e-7 Intelligence (multi-trait analysis); CESC cis rs2625529 0.824 rs12439900 chr15:72373640 A/G cg16672083 chr15:72433130 SENP8 -0.37 -5.06 -0.3 7.75e-7 Red blood cell count; CESC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC trans rs9325144 0.513 rs7977596 chr12:38649067 C/A cg23762105 chr12:34175262 ALG10 0.48 6.31 0.36 1.15e-9 Morning vs. evening chronotype; CESC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.23 -0.31 3.48e-7 Obesity-related traits; CESC cis rs7178572 0.568 rs1823100 chr15:77402744 C/T cg22256960 chr15:77711686 NA -0.54 -6.79 -0.38 7.49e-11 Type 2 diabetes; CESC cis rs9937943 0.616 rs12923487 chr16:74644112 G/T cg01733217 chr16:74700730 RFWD3 0.59 5.27 0.31 2.89e-7 Neutrophil percentage of white cells; CESC cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg06212747 chr3:49208901 KLHDC8B 0.71 9.52 0.5 1.16e-18 Parkinson's disease; CESC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg16680214 chr1:154839983 KCNN3 -0.47 -7.13 -0.4 9.41e-12 Prostate cancer; CESC cis rs11122272 0.735 rs2808580 chr1:231509259 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs7523050 0.643 rs35885176 chr1:109401868 G/A cg08274380 chr1:109419600 GPSM2 0.86 5.69 0.33 3.36e-8 Fat distribution (HIV); CESC cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg17211192 chr8:82754475 SNX16 0.68 8.12 0.45 1.77e-14 Diastolic blood pressure; CESC cis rs7264396 0.747 rs2425112 chr20:34319775 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.75 -0.59 5.91e-26 Total cholesterol levels; CESC cis rs12477438 0.798 rs6542848 chr2:99573732 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.48 -0.54 1.03e-21 Chronic sinus infection; CESC cis rs6032067 0.925 rs6032061 chr20:43853276 C/T cg10761708 chr20:43804764 PI3 0.52 6.26 0.36 1.57e-9 Blood protein levels; CESC cis rs36051895 0.555 rs6476953 chr9:5248742 C/T cg02405213 chr9:5042618 JAK2 -0.54 -6.51 -0.37 3.76e-10 Pediatric autoimmune diseases; CESC cis rs10870270 1.000 rs10159943 chr10:133744744 T/C cg26149184 chr10:133730230 NA 0.37 5.09 0.3 6.85e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg08888203 chr3:10149979 C3orf24 0.49 6.17 0.35 2.51e-9 Alzheimer's disease; CESC cis rs3749237 0.595 rs7643845 chr3:49530711 A/G cg02487422 chr3:49467188 NICN1 0.56 8.19 0.45 1.09e-14 Resting heart rate; CESC cis rs72781680 1.000 rs72796328 chr2:24141343 A/G cg20701182 chr2:24300061 SF3B14 0.78 6.73 0.38 1.07e-10 Lymphocyte counts; CESC cis rs9611565 0.500 rs10775759 chr22:42088158 T/C cg17376030 chr22:41985996 PMM1 -0.67 -7.37 -0.41 2.18e-12 Vitiligo; CESC cis rs6543140 0.964 rs13390895 chr2:103075499 G/A cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg25427524 chr10:38739819 LOC399744 -0.69 -10.26 -0.53 5.12e-21 Extrinsic epigenetic age acceleration; CESC cis rs9457247 0.663 rs2301436 chr6:167437988 C/T cg23791538 chr6:167370224 RNASET2 -0.55 -7.5 -0.42 9.65e-13 Crohn's disease; CESC cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.88 0.34 1.26e-8 Colonoscopy-negative controls vs population controls; CESC cis rs62045849 0.557 rs6500533 chr16:89190065 G/A cg26950739 chr16:89183275 ACSF3 0.58 5.25 0.31 3.13e-7 Red blood cell count; CESC cis rs9614461 0.702 rs2294202 chr22:45738327 A/T cg01808030 chr22:45809952 RIBC2;SMC1B 0.72 7.66 0.43 3.57e-13 Tonsillectomy; CESC cis rs778371 1.000 rs11535 chr2:233743532 G/C cg08000102 chr2:233561755 GIGYF2 -0.82 -13.13 -0.63 1.11e-30 Schizophrenia; CESC cis rs4704187 0.687 rs1903839 chr5:74421397 A/G cg03227963 chr5:74354835 NA 0.31 5.7 0.33 3.22e-8 Response to amphetamines; CESC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.78 0.33 2.06e-8 Personality dimensions; CESC cis rs7243790 0.805 rs12458280 chr18:51913142 C/T cg04730925 chr18:51795821 POLI -0.43 -5.78 -0.33 2.04e-8 Diastolic blood pressure; CESC cis rs367943 0.712 rs4331889 chr5:112679795 C/T cg12552261 chr5:112820674 MCC 0.4 5.2 0.3 4.03e-7 Type 2 diabetes; CESC cis rs6541297 0.645 rs638112 chr1:230310736 C/A cg20703242 chr1:230279135 GALNT2 -0.43 -5.56 -0.32 6.46e-8 Coronary artery disease; CESC cis rs7267979 1.000 rs2259837 chr20:25280205 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs9811920 0.638 rs7629426 chr3:99652577 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.61 -9.74 -0.51 2.34e-19 Axial length; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11969144 chr1:87797684 LMO4 -0.5 -6.69 -0.38 1.34e-10 Fibrinogen levels; CESC cis rs36051895 0.530 rs6476951 chr9:5221614 A/G cg02405213 chr9:5042618 JAK2 -0.53 -6.54 -0.37 3.19e-10 Pediatric autoimmune diseases; CESC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg24829409 chr8:58192753 C8orf71 -0.75 -9.84 -0.52 1.15e-19 Developmental language disorder (linguistic errors); CESC cis rs6963495 0.592 rs114793754 chr7:105152162 G/C cg02135003 chr7:105160482 PUS7 -0.46 -5.46 -0.32 1.08e-7 Bipolar disorder (body mass index interaction); CESC cis rs6570726 0.818 rs952405 chr6:145925952 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.39 0.37 7.61e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7904368 0.754 rs66491181 chr10:16849430 T/C cg23933602 chr10:16859644 RSU1 0.72 7.2 0.4 6.08e-12 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs1595825 0.891 rs60129872 chr2:198653192 A/G cg00982548 chr2:198649783 BOLL -0.47 -5.08 -0.3 7.12e-7 Ulcerative colitis; CESC cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg10523679 chr1:76189770 ACADM 0.65 6.22 0.36 1.93e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7178572 0.568 rs12900433 chr15:77495028 T/C cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC cis rs9287719 0.870 rs10167676 chr2:10753140 G/A cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs735396 1.000 rs1169311 chr12:121440731 C/T cg02403541 chr12:121454288 C12orf43 0.64 9.22 0.49 9.65e-18 N-glycan levels; CESC cis rs2735413 0.918 rs11646244 chr16:78082453 T/C cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs9303401 0.527 rs2116450 chr17:56745561 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.04 12.96 0.62 4.32e-30 Cognitive test performance; CESC cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg09658497 chr7:2847517 GNA12 -0.4 -5.12 -0.3 5.88e-7 Height; CESC cis rs933688 1.000 rs12655973 chr5:90736537 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.96 12.6 0.61 7.43e-29 Smoking behavior; CESC trans rs4843747 0.671 rs72818577 chr16:88111181 G/A cg26811252 chr16:29126840 RRN3P2 0.69 9.82 0.52 1.32e-19 Menopause (age at onset); CESC cis rs7236492 0.748 rs11664153 chr18:77195813 G/A cg15644404 chr18:77186268 NFATC1 -0.69 -5.32 -0.31 2.16e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs10751667 0.643 rs7942693 chr11:957832 G/A cg01483505 chr11:975446 AP2A2 0.37 5.05 0.3 8.3e-7 Alzheimer's disease (late onset); CESC cis rs2880765 0.835 rs2170735 chr15:86043485 G/A cg10818794 chr15:86012489 AKAP13 -0.34 -5.16 -0.3 4.93e-7 Coronary artery disease; CESC cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg09165964 chr15:75287851 SCAMP5 -0.77 -9.55 -0.51 9.13e-19 Blood trace element (Zn levels); CESC cis rs718433 0.584 rs2874142 chr14:22218320 T/A cg02257791 chr14:22217085 NA -0.32 -5.08 -0.3 7.19e-7 Intraocular pressure; CESC cis rs9818758 0.607 rs4855860 chr3:49526044 A/T cg00383909 chr3:49044727 WDR6 -0.86 -5.67 -0.33 3.81e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg00166722 chr3:10149974 C3orf24 0.46 5.78 0.33 2.08e-8 Alzheimer's disease; CESC cis rs5769765 0.908 rs9616396 chr22:50317825 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.63 -6.44 -0.37 5.53e-10 Schizophrenia; CESC cis rs2991971 0.967 rs12743512 chr1:45954033 A/G cg05343316 chr1:45956843 TESK2 0.5 6.54 0.37 3.11e-10 High light scatter reticulocyte count; CESC trans rs1814175 0.817 rs10839397 chr11:49857074 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.98 -0.78 8.73e-55 Height; CESC cis rs9976767 0.637 rs9984108 chr21:43825628 T/G cg23042151 chr21:43824109 UBASH3A -0.33 -6.17 -0.35 2.55e-9 Type 1 diabetes; CESC cis rs3768617 0.510 rs10737245 chr1:183100884 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg07414643 chr4:187882934 NA 0.56 8.14 0.45 1.53e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs36051895 0.695 rs62541532 chr9:5017384 C/A cg02405213 chr9:5042618 JAK2 -0.48 -5.31 -0.31 2.33e-7 Pediatric autoimmune diseases; CESC cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg06027949 chr8:82754900 SNX16 -0.44 -5.23 -0.31 3.48e-7 Diastolic blood pressure; CESC cis rs9926296 0.632 rs1800286 chr16:89869761 T/C cg04287289 chr16:89883240 FANCA 0.64 8.13 0.45 1.63e-14 Vitiligo; CESC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.95 10.23 0.53 6.21e-21 Platelet count; CESC cis rs12971120 1.000 rs2278162 chr18:72175814 A/G cg25817165 chr18:72167213 CNDP2 -0.64 -8.2 -0.45 1.06e-14 Refractive error; CESC cis rs7523050 0.730 rs12079547 chr1:109469314 A/C cg08274380 chr1:109419600 GPSM2 0.79 5.92 0.34 9.72e-9 Fat distribution (HIV); CESC cis rs9549367 0.713 rs553316 chr13:113838015 A/G cg00898013 chr13:113819073 PROZ 0.46 6.88 0.39 4.4e-11 Platelet distribution width; CESC cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg21399703 chr1:247681439 NA 0.6 7.76 0.43 1.87e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg12386194 chr3:101231763 SENP7 0.59 6.48 0.37 4.48e-10 Colonoscopy-negative controls vs population controls; CESC cis rs919433 0.680 rs8539 chr2:198362018 A/G cg03934865 chr2:198174659 NA 0.43 5.81 0.34 1.82e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Parkinson's disease; CESC trans rs66573146 1.000 rs67067921 chr4:6984341 A/T cg07817883 chr1:32538562 TMEM39B 1.47 9.22 0.49 9.35e-18 Granulocyte percentage of myeloid white cells; CESC cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg21385522 chr1:16154831 NA 0.6 7.24 0.41 4.95e-12 Dilated cardiomyopathy; CESC cis rs9486719 0.843 rs3860230 chr6:97036560 T/A cg06623918 chr6:96969491 KIAA0776 -0.88 -10.5 -0.54 8.92e-22 Migraine;Coronary artery disease; CESC cis rs7542091 0.704 rs7537294 chr1:210043777 A/G cg23283495 chr1:209979779 IRF6 0.35 5.8 0.34 1.84e-8 Monobrow; CESC cis rs9399137 0.529 rs7739722 chr6:135282225 T/C cg24558204 chr6:135376177 HBS1L 0.71 9.6 0.51 6.54e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs826838 0.616 rs4619214 chr12:38614704 C/A cg26384229 chr12:38710491 ALG10B 0.46 6.62 0.38 1.96e-10 Heart rate; CESC cis rs2074585 0.517 rs11635361 chr15:91081791 G/T cg10434728 chr15:90938212 IQGAP1 -0.32 -5.32 -0.31 2.16e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs926392 0.640 rs62202616 chr20:37692775 G/C cg16355469 chr20:37678765 NA 0.57 6.48 0.37 4.58e-10 Dialysis-related mortality; CESC cis rs854765 0.647 rs4365346 chr17:17989373 G/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 5.96 0.34 8.22e-9 Total body bone mineral density; CESC cis rs8114671 0.836 rs6120778 chr20:33565169 T/C cg07148914 chr20:33460835 GGT7 0.43 5.46 0.32 1.09e-7 Height; CESC cis rs372883 0.506 rs2832301 chr21:30749712 G/A cg24692254 chr21:30365293 RNF160 0.47 5.89 0.34 1.14e-8 Pancreatic cancer; CESC cis rs3096299 0.967 rs2965937 chr16:89488779 A/T cg16743903 chr16:89593216 SPG7 -0.42 -5.51 -0.32 8.3e-8 Multiple myeloma (IgH translocation); CESC cis rs4148883 0.651 rs10020052 chr4:100086331 C/G cg13256891 chr4:100009986 ADH5 0.53 6.93 0.39 3.22e-11 Alcohol dependence; CESC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg00815214 chr21:47717953 NA -0.42 -6.09 -0.35 3.9e-9 Testicular germ cell tumor; CESC cis rs654950 1.000 rs621680 chr1:41984584 C/T cg06885757 chr1:42089581 HIVEP3 -0.47 -7.24 -0.41 4.9e-12 Airway imaging phenotypes; CESC cis rs8114671 0.562 rs34837802 chr20:33424908 C/G cg08999081 chr20:33150536 PIGU 0.38 5.49 0.32 9.61e-8 Height; CESC cis rs10876993 0.928 rs813854 chr12:58071347 A/G cg18357645 chr12:58087776 OS9 0.63 10.45 0.54 1.28e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg22875332 chr1:76189707 ACADM -0.58 -6.06 -0.35 4.53e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1983170 0.736 rs12127718 chr1:91997490 A/T cg02896835 chr1:92012615 NA 0.57 6.32 0.36 1.13e-9 Eosinophil percentage of white cells; CESC trans rs7615952 0.673 rs9289270 chr3:125636979 A/T cg07211511 chr3:129823064 LOC729375 -0.87 -7.64 -0.42 3.97e-13 Blood pressure (smoking interaction); CESC cis rs2276314 0.748 rs4799839 chr18:33597531 T/C cg19628046 chr18:33552617 C18orf21 0.51 5.58 0.32 5.92e-8 Endometriosis;Drug-induced torsades de pointes; CESC trans rs3942852 0.774 rs10838811 chr11:48186795 A/G cg15704280 chr7:45808275 SEPT13 -0.73 -8.31 -0.45 5.08e-15 Acute lymphoblastic leukemia (childhood); CESC cis rs932287 0.666 rs10840161 chr11:9053824 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.34 5.61 0.33 5.11e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05349356 chr20:3451609 ATRN 0.56 6.21 0.36 2.03e-9 Gut microbiome composition (summer); CESC cis rs11792861 0.546 rs7873569 chr9:111796753 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.37 5.03 0.3 9.03e-7 Menarche (age at onset); CESC cis rs3008870 0.755 rs2815381 chr1:67514591 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.55 6.81 0.39 6.64e-11 Lymphocyte percentage of white cells; CESC cis rs28595532 1.000 rs11938970 chr4:119660152 A/G cg21605333 chr4:119757512 SEC24D 1.07 6.5 0.37 4.08e-10 Cannabis dependence symptom count; CESC cis rs72792276 1.000 rs17839658 chr5:127423013 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.67 5.42 0.32 1.36e-7 Red cell distribution width; CESC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.1 0.81 4.4e-62 Prudent dietary pattern; CESC trans rs1223629 1.000 rs1223632 chr10:95905614 T/C cg21019522 chr11:2920789 SLC22A18;SLC22A18AS -0.72 -6.02 -0.35 5.71e-9 Glucose homeostasis traits; CESC cis rs36051895 0.659 rs16922576 chr9:5064193 T/C cg02405213 chr9:5042618 JAK2 -0.48 -5.87 -0.34 1.29e-8 Pediatric autoimmune diseases; CESC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg00129232 chr17:37814104 STARD3 -0.57 -7.49 -0.42 1.02e-12 Glomerular filtration rate (creatinine); CESC cis rs6967414 0.579 rs6968879 chr7:6757886 T/G cg00387323 chr7:6746715 ZNF12 0.61 5.77 0.33 2.21e-8 Hematocrit;Hemoglobin concentration; CESC cis rs1050631 0.592 rs1789508 chr18:33736845 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.52 7.16 0.4 7.96e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs6831352 0.879 rs36034266 chr4:100061388 T/C cg13256891 chr4:100009986 ADH5 -0.75 -8.21 -0.45 9.89e-15 Alcohol dependence; CESC cis rs17095355 1.000 rs17126890 chr10:111699169 T/C cg00817464 chr10:111662876 XPNPEP1 -0.43 -5.23 -0.31 3.37e-7 Biliary atresia; CESC cis rs57083693 0.518 rs1009090 chr12:101703251 C/T cg22051763 chr12:101673672 UTP20 -0.45 -5.68 -0.33 3.61e-8 Alcohol dependence (age at onset); CESC cis rs8072100 0.934 rs6504872 chr17:45438952 C/T cg25173405 chr17:45401733 C17orf57 -0.43 -5.71 -0.33 3.07e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.36 -0.36 8.66e-10 Depression; CESC cis rs17253792 0.822 rs74720318 chr14:56099828 G/T cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs7824557 0.628 rs3174048 chr8:11184937 G/A cg21775007 chr8:11205619 TDH 0.55 8.7 0.47 3.67e-16 Retinal vascular caliber; CESC cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg10523679 chr1:76189770 ACADM -0.7 -8.07 -0.44 2.39e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs34172651 0.571 rs9922156 chr16:24704329 C/A cg00339695 chr16:24857497 SLC5A11 -0.45 -6.0 -0.35 6.55e-9 Intelligence (multi-trait analysis); CESC cis rs61935443 0.666 rs73218073 chr12:95314346 A/G cg21533806 chr12:95267307 NA 0.5 5.44 0.32 1.24e-7 Schizophrenia; CESC cis rs7208859 0.562 rs216408 chr17:28907757 C/G cg14008862 chr17:28927542 LRRC37B2 -0.7 -6.51 -0.37 3.65e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11723261 0.621 rs11721745 chr4:114934 T/G cg12746427 chr4:53362 ZNF718;ZNF595 0.43 5.16 0.3 4.74e-7 Immune response to smallpox vaccine (IL-6); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23661578 chr6:42981936 MEA1;KLHDC3 0.56 6.48 0.37 4.47e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.918 rs7290404 chr22:41749796 C/T cg06481639 chr22:41940642 POLR3H -0.71 -7.63 -0.42 4.11e-13 Vitiligo; CESC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 6.01 0.35 6.05e-9 Bipolar disorder; CESC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg00701064 chr4:6280414 WFS1 0.73 12.87 0.62 9e-30 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs9929218 0.954 rs7199991 chr16:68818245 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -8.59 -0.47 7.34e-16 Colorectal cancer; CESC cis rs9527 0.545 rs7915816 chr10:104881750 A/G cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg27165867 chr14:105738592 BRF1 -0.54 -6.04 -0.35 5.27e-9 Mean platelet volume;Platelet distribution width; CESC cis rs367943 1.000 rs348957 chr5:112821178 C/T cg12552261 chr5:112820674 MCC 0.64 8.05 0.44 2.83e-14 Type 2 diabetes; CESC trans rs1945213 0.694 rs34390414 chr11:55863367 T/G cg15704280 chr7:45808275 SEPT13 0.7 6.72 0.38 1.1e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs60843830 1.000 rs17714252 chr2:285471 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.89 12.24 0.6 1.37e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4704187 0.687 rs9763362 chr5:74406316 T/C cg03227963 chr5:74354835 NA 0.32 5.94 0.34 8.7e-9 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02011054 chr11:2950754 PHLDA2 0.65 7.46 0.42 1.27e-12 Gut microbiome composition (summer); CESC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.89 9.28 0.5 6.15e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1050631 1.000 rs11081934 chr18:33705304 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.45 5.83 0.34 1.6e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs4474465 1.000 rs7121283 chr11:78149340 T/A cg27205649 chr11:78285834 NARS2 -0.42 -5.19 -0.3 4.22e-7 Alzheimer's disease (survival time); CESC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg18252515 chr7:66147081 NA 0.5 6.62 0.38 1.96e-10 Aortic root size; CESC cis rs7264396 0.790 rs761826 chr20:34194243 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.45 5.48 0.32 9.78e-8 Total cholesterol levels; CESC cis rs4073221 0.520 rs13067391 chr3:18191929 C/T cg07694806 chr3:18168406 NA -0.71 -5.59 -0.32 5.74e-8 Parkinson's disease; CESC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg05564831 chr3:52568323 NT5DC2 0.44 7.02 0.4 1.89e-11 Electroencephalogram traits; CESC cis rs965513 1.000 rs925489 chr9:100546600 C/T cg13688889 chr9:100608707 NA -0.6 -8.5 -0.46 1.38e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs2239547 0.522 rs2581797 chr3:52972468 C/T cg11645453 chr3:52864694 ITIH4 -0.32 -5.42 -0.32 1.33e-7 Schizophrenia; CESC cis rs7301826 0.651 rs10848209 chr12:131311272 A/G cg11011512 chr12:131303247 STX2 0.46 5.56 0.32 6.57e-8 Plasma plasminogen activator levels; CESC cis rs17376456 0.877 rs10514380 chr5:93409370 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.23 0.31 3.49e-7 Diabetic retinopathy; CESC cis rs9828933 0.752 rs13434089 chr3:63948566 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.9 8.04 0.44 2.94e-14 Type 2 diabetes; CESC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg09359103 chr1:154839909 KCNN3 -0.68 -13.05 -0.63 2.11e-30 Prostate cancer; CESC cis rs34779708 0.706 rs36027395 chr10:35550323 T/A cg04310649 chr10:35416472 CREM -0.46 -5.21 -0.3 3.75e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs901683 1.000 rs71496608 chr10:46017132 G/A cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs75804782 0.641 rs57080728 chr2:239350487 T/C cg18131467 chr2:239335373 ASB1 -0.67 -5.91 -0.34 1.06e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs4566357 0.930 rs6436647 chr2:227922958 G/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.28 -0.31 2.76e-7 Coronary artery disease; CESC cis rs7208859 0.623 rs55938328 chr17:29117010 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1879734 0.731 rs7555908 chr1:54158462 A/G cg23596471 chr1:54105337 GLIS1 0.35 5.67 0.33 3.77e-8 Mitral valve prolapse; CESC cis rs425277 0.527 rs3107144 chr1:2045380 C/A cg16545954 chr1:2118288 C1orf86 -0.32 -5.98 -0.34 7.26e-9 Height; CESC cis rs12602901 0.519 rs238238 chr17:4856376 A/G cg24768135 chr17:4805392 CHRNE;C17orf107 0.35 5.42 0.32 1.33e-7 Blood metabolite levels; CESC cis rs7586879 0.639 rs3903070 chr2:25123463 C/G cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.02e-11 Body mass index; CESC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg19748678 chr4:122722346 EXOSC9 0.79 9.99 0.52 3.82e-20 Type 2 diabetes; CESC cis rs4727027 0.704 rs13229244 chr7:148898219 A/C cg23583168 chr7:148888333 NA 0.95 17.1 0.72 1.13e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg22433210 chr17:43662623 NA -0.91 -10.79 -0.55 9.74e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9399137 0.507 rs4520025 chr6:135278619 G/T cg22676075 chr6:135203613 NA 0.54 7.12 0.4 1.04e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg12826209 chr6:26865740 GUSBL1 0.73 7.83 0.43 1.17e-13 Intelligence (multi-trait analysis); CESC cis rs36051895 0.695 rs7043489 chr9:5023604 A/C cg02405213 chr9:5042618 JAK2 -0.48 -5.95 -0.34 8.24e-9 Pediatric autoimmune diseases; CESC trans rs10743315 0.557 rs16915323 chr12:19437529 A/G cg09562322 chr12:119419143 SRRM4 -0.43 -6.36 -0.36 8.83e-10 Gut microbiota (bacterial taxa); CESC cis rs6142102 0.538 rs6142058 chr20:32542801 A/G cg08999081 chr20:33150536 PIGU 0.34 5.12 0.3 5.81e-7 Skin pigmentation; CESC cis rs16910800 0.731 rs59333536 chr11:23191649 G/A cg20040320 chr11:23191996 NA -0.67 -6.66 -0.38 1.53e-10 Cancer; CESC cis rs6460942 0.730 rs73053536 chr7:12323131 C/G cg06484146 chr7:12443880 VWDE -0.8 -8.19 -0.45 1.08e-14 Coronary artery disease; CESC cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg00677455 chr12:58241039 CTDSP2 0.51 6.6 0.38 2.17e-10 Multiple sclerosis; CESC cis rs2404602 0.692 rs12595586 chr15:77172210 A/G cg22467129 chr15:76604101 ETFA -0.35 -5.23 -0.31 3.42e-7 Blood metabolite levels; CESC cis rs6831352 0.918 rs34805407 chr4:100050786 C/A cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg17971929 chr21:40555470 PSMG1 -0.88 -12.76 -0.62 2.2e-29 Cognitive function; CESC cis rs7772486 0.625 rs9390355 chr6:146112942 C/T cg23711669 chr6:146136114 FBXO30 -0.91 -13.64 -0.64 1.86e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs922182 0.569 rs72752984 chr15:64264082 G/T cg24729988 chr15:64271149 DAPK2 0.4 5.32 0.31 2.21e-7 Blood protein levels; CESC cis rs3126085 0.935 rs4845751 chr1:152208997 T/C cg03465714 chr1:152285911 FLG -0.43 -5.17 -0.3 4.53e-7 Atopic dermatitis; CESC cis rs4727027 0.901 rs10952792 chr7:148760501 C/T cg23158103 chr7:148848205 ZNF398 -0.41 -6.56 -0.37 2.74e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7267979 0.844 rs6107017 chr20:25232300 A/G cg08601574 chr20:25228251 PYGB 0.42 5.81 0.34 1.82e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9309473 0.687 rs12465867 chr2:73612102 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -6.49 -0.37 4.22e-10 Metabolite levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09529537 chr5:78531947 JMY 0.48 6.64 0.38 1.74e-10 Systemic lupus erythematosus; CESC cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.33 5.34 0.31 2.05e-7 Monocyte percentage of white cells; CESC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg17724175 chr1:150552817 MCL1 -0.45 -7.33 -0.41 2.71e-12 Tonsillectomy; CESC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg07677032 chr17:61819896 STRADA 0.41 5.22 0.31 3.57e-7 Height; CESC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg11764359 chr7:65958608 NA -0.78 -11.22 -0.57 3.73e-24 Aortic root size; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05208423 chr11:13689596 FAR1 0.5 6.55 0.37 2.91e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7914558 1.000 rs1926030 chr10:104855656 T/C cg04362960 chr10:104952993 NT5C2 0.46 5.9 0.34 1.09e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7077164 1.000 rs1227775 chr10:71580862 C/G cg20696214 chr10:71583771 COL13A1 -0.46 -6.56 -0.37 2.74e-10 Non-alcoholic fatty liver disease histology (lobular); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20272604 chr1:231004631 C1orf198 -0.48 -6.01 -0.35 5.99e-9 Ulcerative colitis; CESC cis rs9916302 0.561 rs12453198 chr17:37741879 T/C cg00129232 chr17:37814104 STARD3 -0.55 -5.22 -0.31 3.64e-7 Glomerular filtration rate (creatinine); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg14684675 chr11:66139712 SLC29A2 -0.4 -6.55 -0.37 3.02e-10 Breast cancer; CESC cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg10556349 chr10:835070 NA 0.51 5.04 0.3 8.56e-7 Eosinophil percentage of granulocytes; CESC cis rs4242434 0.536 rs1871900 chr8:22481449 A/G cg03733263 chr8:22462867 KIAA1967 0.63 8.97 0.48 5.6e-17 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg12311346 chr5:56204834 C5orf35 -0.73 -8.56 -0.47 9.08e-16 Initial pursuit acceleration; CESC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg09060608 chr5:178986726 RUFY1 -0.53 -8.23 -0.45 8.57e-15 Lung cancer; CESC cis rs4523957 0.820 rs7212249 chr17:2135980 A/T cg16513277 chr17:2031491 SMG6 -0.64 -9.0 -0.48 4.46e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg03138854 chr1:159895315 TAGLN2 -0.52 -6.29 -0.36 1.28e-9 Gut microbiota (bacterial taxa); CESC cis rs910316 1.000 rs1043674 chr14:75549370 T/C cg08847533 chr14:75593920 NEK9 1.01 19.32 0.76 1.63e-52 Height; CESC cis rs2290159 0.800 rs5746191 chr3:12658774 G/A cg23032965 chr3:12705835 RAF1 0.53 5.71 0.33 3.04e-8 Cholesterol, total; CESC cis rs10791097 0.739 rs12279359 chr11:130730544 G/A cg12179176 chr11:130786555 SNX19 0.56 8.14 0.45 1.57e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06561044 chr16:67969622 PSMB10 0.6 6.92 0.39 3.46e-11 Gut microbiome composition (summer); CESC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg21226059 chr5:178986404 RUFY1 0.51 7.96 0.44 5.11e-14 Lung cancer; CESC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg03538708 chr1:25844672 NA -0.41 -6.03 -0.35 5.49e-9 Erythrocyte sedimentation rate; CESC cis rs12681288 0.823 rs2701905 chr8:1003482 T/C cg15309053 chr8:964076 NA 0.36 6.22 0.36 1.95e-9 Schizophrenia; CESC trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg15704280 chr7:45808275 SEPT13 -0.56 -6.73 -0.38 1.07e-10 HDL cholesterol; CESC cis rs2361718 0.568 rs1042397 chr17:78092063 G/A cg06718696 chr17:78121285 EIF4A3 0.4 5.07 0.3 7.53e-7 Yeast infection; CESC cis rs28829049 0.861 rs10492996 chr1:19365552 C/T cg13387374 chr1:19411106 UBR4 0.44 5.71 0.33 2.98e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg06481639 chr22:41940642 POLR3H -0.61 -6.46 -0.37 4.88e-10 Vitiligo; CESC cis rs1707322 0.686 rs61784833 chr1:46233772 T/C cg05343316 chr1:45956843 TESK2 0.5 6.16 0.35 2.72e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7119 0.717 rs34981488 chr15:77723403 T/G cg17802220 chr15:77601643 NA -0.54 -7.5 -0.42 9.44e-13 Type 2 diabetes; CESC cis rs6963495 0.818 rs1721498 chr7:105178819 A/C cg02135003 chr7:105160482 PUS7 0.44 6.17 0.35 2.6e-9 Bipolar disorder (body mass index interaction); CESC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg23161317 chr6:28129485 ZNF389 -0.43 -5.62 -0.33 4.74e-8 Depression; CESC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.43 -6.16 -0.35 2.73e-9 IgG glycosylation; CESC cis rs739401 0.611 rs450817 chr11:3056712 A/G cg25174290 chr11:3078921 CARS 0.55 7.65 0.43 3.75e-13 Longevity; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg25974723 chr19:50119415 PRR12 -0.44 -6.01 -0.35 6.22e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4660261 0.545 rs803682 chr1:44362623 G/A cg23954153 chr1:44402353 ARTN -0.35 -5.59 -0.32 5.69e-8 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC cis rs67311347 0.911 rs6775936 chr3:40377399 T/G cg09455208 chr3:40491958 NA 0.48 8.3 0.45 5.47e-15 Renal cell carcinoma; CESC cis rs1801251 1.000 rs6717841 chr2:233590255 C/T cg25237894 chr2:233734115 C2orf82 0.48 8.19 0.45 1.08e-14 Coronary artery disease; CESC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg06108461 chr20:60628389 TAF4 0.83 11.48 0.58 4.88e-25 Body mass index; CESC cis rs67311347 1.000 rs2371186 chr3:40488713 G/C cg24209194 chr3:40518798 ZNF619 0.5 6.26 0.36 1.54e-9 Renal cell carcinoma; CESC cis rs3733585 0.699 rs6449171 chr4:9965998 C/T cg02734326 chr4:10020555 SLC2A9 0.44 5.99 0.35 6.77e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9527 0.590 rs11191547 chr10:104843148 C/T cg04362960 chr10:104952993 NT5C2 0.45 5.66 0.33 3.87e-8 Arsenic metabolism; CESC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg01988459 chr11:68622903 NA -0.46 -6.62 -0.38 2.03e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg11905131 chr22:24372483 LOC391322 -0.73 -10.65 -0.55 2.71e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg18357526 chr6:26021779 HIST1H4A 0.47 5.77 0.33 2.18e-8 Intelligence (multi-trait analysis); CESC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs796364 0.806 rs11684942 chr2:201009136 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -6.83 -0.39 5.71e-11 Schizophrenia; CESC cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.7 10.93 0.56 3.27e-23 Personality dimensions; CESC cis rs1003719 0.715 rs2212742 chr21:38578685 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.14 -0.45 1.58e-14 Eye color traits; CESC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.66 0.38 1.54e-10 Bipolar disorder; CESC trans rs2823962 0.759 rs8134854 chr21:18016042 C/T cg01437917 chr17:4688569 NA -0.44 -6.21 -0.36 2.02e-9 Amyotrophic lateral sclerosis; CESC cis rs593982 1.000 rs593982 chr11:65513107 T/C cg08755490 chr11:65554678 OVOL1 1.31 19.94 0.77 1.14e-54 Atopic dermatitis; CESC cis rs6951245 0.507 rs10227709 chr7:1180515 T/G cg04025307 chr7:1156635 C7orf50 0.36 5.06 0.3 8.02e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12410462 1.000 rs6672162 chr1:227632335 G/A cg23173402 chr1:227635558 NA 0.59 6.06 0.35 4.66e-9 Major depressive disorder; CESC cis rs1707322 0.721 rs4660314 chr1:46229885 T/C cg05343316 chr1:45956843 TESK2 0.5 6.13 0.35 3.23e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14214745 chr3:9975533 CRELD1 0.47 6.64 0.38 1.78e-10 Intelligence (multi-trait analysis); CESC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg16545954 chr1:2118288 C1orf86 -0.31 -6.02 -0.35 5.77e-9 Height; CESC cis rs8067545 1.000 rs8071730 chr17:19932731 C/T cg13482628 chr17:19912719 NA 0.46 6.2 0.36 2.19e-9 Schizophrenia; CESC cis rs763121 0.853 rs138713 chr22:39142615 T/C cg21395723 chr22:39101663 GTPBP1 0.47 6.26 0.36 1.55e-9 Menopause (age at onset); CESC cis rs3857536 0.813 rs9453639 chr6:66933538 C/T cg07460842 chr6:66804631 NA -0.42 -5.36 -0.31 1.8e-7 Blood trace element (Cu levels); CESC cis rs734999 0.545 rs7364820 chr1:2556709 G/A cg18854424 chr1:2615690 NA 0.31 5.91 0.34 1.08e-8 Ulcerative colitis; CESC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg18230493 chr5:56204884 C5orf35 -0.72 -8.78 -0.47 2.09e-16 Initial pursuit acceleration; CESC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg13770153 chr20:60521292 NA -0.51 -6.47 -0.37 4.81e-10 Body mass index; CESC cis rs17253792 0.555 rs17683626 chr14:56041112 G/T cg01858014 chr14:56050164 KTN1 -0.99 -7.46 -0.42 1.21e-12 Putamen volume; CESC cis rs7647973 0.593 rs4855885 chr3:49690199 G/A cg03060546 chr3:49711283 APEH 0.64 7.19 0.4 6.47e-12 Menarche (age at onset); CESC cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg22875332 chr1:76189707 ACADM -0.62 -7.26 -0.41 4.27e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs897080 0.515 rs1067359 chr2:44661997 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.44 0.32 1.2e-7 Height; CESC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.63e-16 Initial pursuit acceleration; CESC cis rs3736485 0.934 rs8036904 chr15:51861438 G/A cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1508086 0.749 rs6987876 chr8:57807943 A/G cg10342016 chr8:57802622 NA -0.31 -5.1 -0.3 6.46e-7 Hand grip strength; CESC cis rs863345 0.967 rs863360 chr1:158549264 G/A cg12129480 chr1:158549410 OR10X1 -0.32 -6.46 -0.37 5.08e-10 Pneumococcal bacteremia; CESC cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg24690094 chr11:67383802 NA -0.37 -6.18 -0.35 2.44e-9 Mean corpuscular volume; CESC cis rs9532580 0.553 rs9549250 chr13:41225229 T/G cg21288729 chr13:41239152 FOXO1 0.65 8.35 0.46 3.76e-15 Mean corpuscular hemoglobin; CESC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg24531977 chr5:56204891 C5orf35 0.68 9.37 0.5 3.26e-18 Initial pursuit acceleration; CESC cis rs36051895 0.589 rs16922779 chr9:5200127 G/A cg02405213 chr9:5042618 JAK2 -0.5 -5.96 -0.34 8.08e-9 Pediatric autoimmune diseases; CESC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg02951883 chr7:2050386 MAD1L1 0.49 6.4 0.37 7.12e-10 Bipolar disorder and schizophrenia; CESC cis rs67460515 0.500 rs1562464 chr3:160681614 G/A cg03342759 chr3:160939853 NMD3 -0.47 -5.87 -0.34 1.31e-8 Parkinson's disease; CESC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg07677032 chr17:61819896 STRADA 0.44 5.88 0.34 1.22e-8 Prudent dietary pattern; CESC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs25645 0.502 rs7223318 chr17:38108553 G/C cg17467752 chr17:38218738 THRA 0.41 5.07 0.3 7.47e-7 Myeloid white cell count; CESC cis rs9303280 0.806 rs12232497 chr17:38040119 T/C cg20243544 chr17:37824526 PNMT 0.53 6.96 0.39 2.6e-11 Self-reported allergy; CESC cis rs12142240 0.920 rs6697623 chr1:46757542 G/A cg00530320 chr1:46809349 NSUN4 0.55 6.89 0.39 3.99e-11 Menopause (age at onset); CESC cis rs4604732 0.642 rs6426252 chr1:247639887 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.38 5.66 0.33 3.84e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs73195822 0.506 rs55948838 chr12:111142793 C/T cg12870014 chr12:110450643 ANKRD13A 0.64 5.51 0.32 8.64e-8 Itch intensity from mosquito bite; CESC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg25838465 chr1:92012736 NA -0.61 -8.89 -0.48 9.45e-17 Breast cancer; CESC cis rs1448094 0.845 rs7966131 chr12:86350633 T/G cg02569458 chr12:86230093 RASSF9 0.39 5.7 0.33 3.18e-8 Major depressive disorder; CESC cis rs9399135 0.967 rs1014020 chr6:135334426 C/A cg22676075 chr6:135203613 NA 0.51 7.21 0.4 5.91e-12 Red blood cell count; CESC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg03396347 chr1:1875803 NA -0.44 -6.85 -0.39 5.19e-11 Body mass index; CESC cis rs4654899 0.802 rs10493004 chr1:21442736 T/C cg05370193 chr1:21551575 ECE1 0.44 6.81 0.39 6.46e-11 Superior frontal gyrus grey matter volume; CESC cis rs9522267 0.535 rs6492373 chr13:112238627 T/C cg10483660 chr13:112241077 NA 0.32 5.63 0.33 4.64e-8 Hepatitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00962125 chr14:24616485 PSME2;RNF31 0.57 6.61 0.38 2.05e-10 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.57 0.54 4.93e-22 Height; CESC cis rs7824557 0.527 rs2572446 chr8:11239565 C/T cg21775007 chr8:11205619 TDH -0.52 -7.79 -0.43 1.53e-13 Retinal vascular caliber; CESC cis rs72634258 0.554 rs17374292 chr1:7881234 C/T cg26816564 chr1:7831052 VAMP3 0.65 6.09 0.35 3.85e-9 Inflammatory bowel disease; CESC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.18 0.4 6.91e-12 Bipolar disorder; CESC cis rs3126085 0.877 rs1552996 chr1:152171104 C/A cg03465714 chr1:152285911 FLG -0.46 -5.62 -0.33 4.83e-8 Atopic dermatitis; CESC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg11644478 chr21:40555479 PSMG1 -0.53 -7.04 -0.4 1.69e-11 Menarche (age at onset); CESC cis rs561341 1.000 rs8064843 chr17:30245744 A/G cg19193384 chr17:30244184 NA -0.53 -5.98 -0.34 7.27e-9 Hip circumference adjusted for BMI; CESC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.07 0.4 1.37e-11 Height; CESC cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.44 5.85 0.34 1.45e-8 Colorectal cancer; CESC cis rs7044106 0.708 rs959558 chr9:123368911 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 9.97 0.52 4.5e-20 Hip circumference adjusted for BMI; CESC cis rs13102973 0.965 rs13103954 chr4:135844189 A/G cg14419869 chr4:135874104 NA 0.33 5.18 0.3 4.35e-7 Subjective well-being; CESC cis rs7605827 0.930 rs10172344 chr2:15521591 A/G cg19274914 chr2:15703543 NA 0.35 6.26 0.36 1.53e-9 Educational attainment (years of education); CESC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg26314531 chr2:26401878 FAM59B -0.76 -8.5 -0.46 1.38e-15 Gut microbiome composition (summer); CESC cis rs7727544 0.735 rs272881 chr5:131669264 G/A cg24060327 chr5:131705240 SLC22A5 -0.67 -8.93 -0.48 7.2e-17 Blood metabolite levels; CESC cis rs2236918 0.710 rs1776130 chr1:242023362 A/G cg17736920 chr1:242011382 EXO1 0.57 7.13 0.4 9.8e-12 Menopause (age at onset); CESC cis rs6752107 0.967 rs55835501 chr2:234157733 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.35 5.44 0.32 1.23e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs3020736 0.500 rs6002616 chr22:42504679 A/G cg12850546 chr22:42539477 CYP2D7P1 0.43 5.16 0.3 4.86e-7 Autism spectrum disorder or schizophrenia; CESC cis rs6032067 0.777 rs62208386 chr20:43790872 G/A cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg02569458 chr12:86230093 RASSF9 0.57 8.34 0.46 4.13e-15 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18780217 chr12:112204756 ALDH2 0.55 6.15 0.35 2.89e-9 Gut microbiome composition (summer); CESC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg01416388 chr22:39784598 NA -0.62 -7.88 -0.44 8.63e-14 Intelligence (multi-trait analysis); CESC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg13944838 chr5:179740914 GFPT2 -0.67 -8.59 -0.47 7.56e-16 Height; CESC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -10.93 -0.56 3.43e-23 Extrinsic epigenetic age acceleration; CESC cis rs7927771 0.524 rs1563821 chr11:47756568 C/T cg20307385 chr11:47447363 PSMC3 0.61 8.6 0.47 7.26e-16 Subjective well-being; CESC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.43 -5.54 -0.32 7.29e-8 Tonsillectomy; CESC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg14393609 chr7:65229607 NA -0.46 -6.13 -0.35 3.17e-9 Calcium levels; CESC cis rs6963495 0.818 rs73192141 chr7:105201129 T/G cg19920283 chr7:105172520 RINT1 0.7 6.37 0.36 8.43e-10 Bipolar disorder (body mass index interaction); CESC cis rs2637266 0.626 rs2583069 chr10:78546775 T/C cg18941641 chr10:78392320 NA 0.4 7.52 0.42 8.34e-13 Pulmonary function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25107978 chr12:57916571 MBD6 0.49 6.01 0.35 6.06e-9 Gut microbiota (bacterial taxa); CESC cis rs853679 0.769 rs17720293 chr6:28214698 C/T cg18032046 chr6:28092343 ZSCAN16 -0.75 -6.01 -0.35 6.03e-9 Depression; CESC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg25767906 chr1:53392781 SCP2 -0.4 -5.08 -0.3 7.1e-7 Monocyte count; CESC cis rs1801251 1.000 rs283477 chr2:233649427 A/G cg08000102 chr2:233561755 GIGYF2 0.68 9.35 0.5 3.74e-18 Coronary artery disease; CESC cis rs8050907 0.744 rs8058798 chr16:4531659 C/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.89 6.22 0.36 1.94e-9 Obesity-related traits; CESC cis rs8038465 0.615 rs4075802 chr15:73963239 A/G cg15420318 chr15:73925796 NPTN 0.56 8.54 0.46 1.04e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9858542 0.953 rs6779524 chr3:49450449 C/T cg03060546 chr3:49711283 APEH -0.54 -6.21 -0.36 2.07e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg18099408 chr3:52552593 STAB1 -0.46 -8.78 -0.47 2e-16 Electroencephalogram traits; CESC cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg00149659 chr3:10157352 C3orf10 1.02 12.06 0.6 5.29e-27 Alzheimer's disease; CESC cis rs9300255 0.679 rs10772998 chr12:123721177 T/G cg19016782 chr12:123741754 C12orf65 -0.48 -6.7 -0.38 1.22e-10 Neutrophil percentage of white cells; CESC cis rs763121 0.626 rs5750643 chr22:39009017 A/G cg06022373 chr22:39101656 GTPBP1 0.94 16.88 0.72 6.58e-44 Menopause (age at onset); CESC cis rs2625529 0.824 rs4777480 chr15:72328997 A/C cg16672083 chr15:72433130 SENP8 -0.38 -5.25 -0.31 3.05e-7 Red blood cell count; CESC cis rs847577 0.515 rs10953238 chr7:97676259 C/T cg24562669 chr7:97807699 LMTK2 0.76 12.76 0.62 2.23e-29 Breast cancer; CESC cis rs9640161 0.673 rs34489187 chr7:150044379 G/A cg27494647 chr7:150038898 RARRES2 0.44 5.24 0.31 3.36e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg02187348 chr16:89574699 SPG7 0.62 8.2 0.45 1.04e-14 Multiple myeloma (IgH translocation); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04631728 chr17:4607671 PELP1 0.45 6.09 0.35 3.9e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9549260 0.755 rs12585277 chr13:41224813 C/T cg21288729 chr13:41239152 FOXO1 0.65 8.5 0.46 1.4e-15 Red blood cell count; CESC cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg06544989 chr22:39130855 UNC84B 0.52 9.06 0.49 2.96e-17 Menopause (age at onset); CESC cis rs3540 0.533 rs7495080 chr15:91056681 G/A cg10434728 chr15:90938212 IQGAP1 -0.39 -7.23 -0.41 5.28e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9549367 0.789 rs57747440 chr13:113894750 C/A cg00898013 chr13:113819073 PROZ -0.51 -6.94 -0.39 3.06e-11 Platelet distribution width; CESC cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.65 -7.56 -0.42 6.55e-13 Multiple sclerosis; CESC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg11764359 chr7:65958608 NA -0.72 -9.68 -0.51 3.48e-19 Aortic root size; CESC cis rs13191362 1.000 rs28360546 chr6:163210973 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.61 5.68 0.33 3.55e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17326317 chr2:69240950 ANTXR1 0.49 6.11 0.35 3.51e-9 Gut microbiome composition (summer); CESC cis rs7116495 1.000 rs7101701 chr11:71762155 A/G cg26138937 chr11:71823887 C11orf51 -0.81 -6.46 -0.37 4.87e-10 Severe influenza A (H1N1) infection; CESC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg03388025 chr16:89894329 SPIRE2 0.41 7.95 0.44 5.32e-14 Vitiligo; CESC cis rs1949733 1.000 rs2631758 chr4:8495304 G/A cg11789530 chr4:8429930 ACOX3 -0.78 -11.05 -0.56 1.37e-23 Response to antineoplastic agents; CESC cis rs8092503 1.000 rs2015502 chr18:52489982 A/G cg12377874 chr18:52495404 RAB27B -0.35 -6.01 -0.35 6.1e-9 Childhood body mass index; CESC trans rs9467711 0.584 rs34244947 chr6:26761745 T/C cg06606381 chr12:133084897 FBRSL1 -0.94 -7.65 -0.43 3.72e-13 Autism spectrum disorder or schizophrenia; CESC cis rs3733585 0.781 rs57250714 chr4:9984529 C/T cg11266682 chr4:10021025 SLC2A9 0.58 10.76 0.55 1.2e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg07395648 chr5:131743802 NA -0.44 -5.71 -0.33 3.04e-8 Blood metabolite levels; CESC cis rs10782582 0.593 rs17647178 chr1:76210524 A/G cg10523679 chr1:76189770 ACADM -0.48 -5.58 -0.32 5.93e-8 Daytime sleep phenotypes; CESC cis rs9287719 0.967 rs7593496 chr2:10738176 A/C cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs3820928 0.904 rs10188570 chr2:227792540 G/A cg11843606 chr2:227700838 RHBDD1 -0.47 -5.85 -0.34 1.42e-8 Pulmonary function; CESC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg08859206 chr1:53392774 SCP2 -0.53 -6.68 -0.38 1.38e-10 Monocyte count; CESC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs2425143 0.598 rs2425118 chr20:34324098 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.86 0.39 4.77e-11 Blood protein levels; CESC cis rs6964587 0.755 rs13229505 chr7:91444679 G/T cg17063962 chr7:91808500 NA 0.49 6.29 0.36 1.29e-9 Breast cancer; CESC trans rs17645023 0.689 rs7220428 chr17:64933218 C/G cg13810570 chr9:35079651 FANCG 0.59 6.03 0.35 5.48e-9 Bipolar disorder and schizophrenia; CESC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg05368731 chr17:41323189 NBR1 0.79 11.14 0.56 6.92e-24 Menopause (age at onset); CESC cis rs35110281 0.774 rs141521 chr21:44963686 G/A cg04455712 chr21:45112962 RRP1B 0.37 5.46 0.32 1.12e-7 Mean corpuscular volume; CESC cis rs6662572 0.737 rs72677518 chr1:46511118 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.2 0.3 4.03e-7 Blood protein levels; CESC cis rs4812048 1.000 rs6070697 chr20:57599402 G/A cg14073986 chr20:57617431 SLMO2 0.64 5.77 0.33 2.18e-8 Mean platelet volume; CESC cis rs4955124 0.558 rs76673738 chr3:32016935 A/G cg05935571 chr3:32023257 ZNF860;OSBPL10 1.0 8.4 0.46 2.67e-15 Schizophrenia; CESC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2749592 0.531 rs10764134 chr10:37856660 T/C cg25427524 chr10:38739819 LOC399744 0.54 7.42 0.41 1.56e-12 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1153858 1.000 rs1980288 chr15:45620612 T/C cg21132104 chr15:45694354 SPATA5L1 0.83 11.01 0.56 1.8e-23 Homoarginine levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03700121 chr11:60610004 CCDC86 0.46 6.45 0.37 5.33e-10 Gut microbiota (bacterial taxa); CESC cis rs7772486 0.686 rs1337839 chr6:146010239 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.79 -0.38 7.46e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4812048 0.689 rs151360 chr20:57613373 T/C cg14073986 chr20:57617431 SLMO2 0.55 5.4 0.32 1.46e-7 Mean platelet volume; CESC cis rs1775715 0.737 rs2799018 chr10:32202069 C/T cg26784012 chr10:32216390 ARHGAP12 0.39 5.18 0.3 4.29e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs79387448 0.638 rs7600961 chr2:103035455 G/A cg09003973 chr2:102972529 NA 0.94 7.74 0.43 2.11e-13 Gut microbiota (bacterial taxa); CESC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.73 -0.51 2.53e-19 Alzheimer's disease; CESC cis rs7998202 0.667 rs914017 chr13:113355037 G/A cg02820901 chr13:113351484 ATP11A 0.65 5.78 0.33 2.05e-8 Glycated hemoglobin levels; CESC cis rs2197308 0.740 rs10880619 chr12:37922720 T/C cg13010199 chr12:38710504 ALG10B 0.53 6.76 0.38 8.79e-11 Morning vs. evening chronotype; CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg05657792 chr17:6899758 ALOX12 0.4 6.91 0.39 3.5e-11 Tonsillectomy; CESC cis rs17376456 1.000 rs34068652 chr5:93563319 G/A cg21475434 chr5:93447410 FAM172A 0.84 7.3 0.41 3.39e-12 Diabetic retinopathy; CESC cis rs7772486 0.875 rs2224120 chr6:146343280 A/C cg05347473 chr6:146136440 FBXO30 0.52 6.71 0.38 1.19e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.31 0.41 3.1e-12 Tonsillectomy; CESC cis rs9768139 0.903 rs10262701 chr7:158114591 G/A cg25566285 chr7:158114605 PTPRN2 -0.59 -10.39 -0.54 1.97e-21 Calcium levels; CESC trans rs2623325 0.874 rs9874386 chr3:99095322 A/C cg19595760 chr1:25948511 MAN1C1 -0.46 -6.23 -0.36 1.82e-9 Optic cup area;Vertical cup-disc ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07312366 chr2:74710011 TTC31;CCDC142 0.62 7.0 0.4 2.07e-11 Gut microbiome composition (summer); CESC cis rs13191362 0.507 rs2849520 chr6:163132038 T/C cg14584255 chr6:163149320 PACRG;PARK2 -0.43 -5.29 -0.31 2.58e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4474465 0.790 rs4945292 chr11:78254424 T/A cg27205649 chr11:78285834 NARS2 0.43 5.34 0.31 2.05e-7 Alzheimer's disease (survival time); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06212607 chr1:235491708 GGPS1;ARID4B 0.43 6.15 0.35 2.91e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2011503 0.882 rs8108777 chr19:19359058 C/A cg11584989 chr19:19387371 SF4 0.54 6.58 0.37 2.46e-10 Bipolar disorder; CESC cis rs763121 0.962 rs138703 chr22:39132748 C/T cg06022373 chr22:39101656 GTPBP1 0.72 11.26 0.57 2.69e-24 Menopause (age at onset); CESC cis rs2262909 1.000 rs2175366 chr19:22128279 C/T cg11619707 chr19:22235551 ZNF257 -0.33 -5.52 -0.32 7.97e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs17376456 0.569 rs11948511 chr5:93286601 A/C cg25358565 chr5:93447407 FAM172A -0.47 -5.43 -0.32 1.25e-7 Diabetic retinopathy; CESC cis rs3824867 0.920 rs10742805 chr11:47454701 A/G cg20307385 chr11:47447363 PSMC3 0.5 6.09 0.35 3.87e-9 Mean corpuscular hemoglobin; CESC cis rs244293 1.000 rs244316 chr17:53215223 G/A cg19360675 chr17:53046073 COX11;STXBP4 -0.41 -5.25 -0.31 3.19e-7 Menarche (age at onset); CESC cis rs1728785 1.000 rs1728784 chr16:68591156 T/A cg02972257 chr16:68554789 NA -0.68 -7.65 -0.43 3.84e-13 Ulcerative colitis; CESC cis rs5747327 0.839 rs2024230 chr22:18132930 C/T cg19898043 chr22:18121309 BCL2L13 -0.4 -5.11 -0.3 6.13e-7 Myeloid white cell count;Granulocyte count; CESC cis rs9457247 0.935 rs2149093 chr6:167373045 T/C cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.66e-7 Crohn's disease; CESC cis rs6088580 0.634 rs6142159 chr20:32993035 G/A cg24642439 chr20:33292090 TP53INP2 -0.53 -6.97 -0.39 2.55e-11 Glomerular filtration rate (creatinine); CESC cis rs17095355 1.000 rs12570230 chr10:111691614 T/C cg00817464 chr10:111662876 XPNPEP1 -0.43 -5.06 -0.3 7.86e-7 Biliary atresia; CESC cis rs3806933 0.500 rs10491423 chr5:110453977 C/A cg04022379 chr5:110408740 TSLP 0.45 7.3 0.41 3.37e-12 Eosinophilic esophagitis; CESC cis rs7762018 1.000 rs1127489 chr6:170107702 C/T cg05834625 chr6:170176447 C6orf70 0.63 7.58 0.42 5.82e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs672059 1.000 rs660602 chr1:183162774 T/G ch.1.3577855R chr1:183094577 LAMC1 0.56 7.17 0.4 7.56e-12 Hypertriglyceridemia; CESC cis rs10751667 0.666 rs10902243 chr11:949900 T/C cg06064525 chr11:970664 AP2A2 -0.48 -9.45 -0.5 1.86e-18 Alzheimer's disease (late onset); CESC cis rs920590 0.876 rs3907478 chr8:19657753 G/T cg03894339 chr8:19674705 INTS10 0.54 6.42 0.37 6.28e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs5769765 0.773 rs9616391 chr22:50314573 C/T cg02269571 chr22:50332266 NA -0.63 -6.82 -0.39 6.18e-11 Schizophrenia; CESC cis rs9300255 0.602 rs941305 chr12:123715266 T/C cg05973401 chr12:123451056 ABCB9 0.5 5.58 0.32 5.95e-8 Neutrophil percentage of white cells; CESC cis rs2594989 1.000 rs2606761 chr3:11344427 G/A cg00170343 chr3:11313890 ATG7 0.59 5.25 0.31 3.1e-7 Circulating chemerin levels; CESC cis rs9287719 0.967 rs6432122 chr2:10753844 A/G cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs3733585 0.624 rs58130873 chr4:9972081 T/C cg00071950 chr4:10020882 SLC2A9 -0.69 -11.32 -0.57 1.7e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9457247 0.765 rs6900701 chr6:167434112 A/G cg07741184 chr6:167504864 NA 0.35 6.27 0.36 1.43e-9 Crohn's disease; CESC cis rs8014204 0.762 rs12889665 chr14:75234830 T/G cg08847533 chr14:75593920 NEK9 0.42 5.56 0.32 6.62e-8 Caffeine consumption; CESC trans rs61931739 0.857 rs999715 chr12:34143253 G/C cg26384229 chr12:38710491 ALG10B 0.48 6.64 0.38 1.8e-10 Morning vs. evening chronotype; CESC cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg07507251 chr3:52567010 NT5DC2 -0.32 -5.5 -0.32 8.9e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg23034840 chr1:205782522 SLC41A1 0.59 6.61 0.38 2.06e-10 Menarche (age at onset); CESC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg13206674 chr6:150067644 NUP43 0.45 6.39 0.37 7.26e-10 Lung cancer; CESC cis rs372883 0.507 rs8132992 chr21:30750561 T/C cg24692254 chr21:30365293 RNF160 0.47 5.89 0.34 1.14e-8 Pancreatic cancer; CESC cis rs9660992 0.573 rs1172139 chr1:205213962 G/A cg21643547 chr1:205240462 TMCC2 -0.39 -5.45 -0.32 1.18e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs12142240 0.698 rs72885198 chr1:46812888 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.85 0.43 1.05e-13 Menopause (age at onset); CESC cis rs3820928 0.804 rs4675125 chr2:227802499 T/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.61 -0.33 5.03e-8 Pulmonary function; CESC cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg03467027 chr4:99064603 C4orf37 0.48 6.05 0.35 4.87e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg06484146 chr7:12443880 VWDE -0.73 -8.75 -0.47 2.6e-16 Coronary artery disease; CESC cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg27398817 chr8:82754497 SNX16 -0.56 -6.53 -0.37 3.27e-10 Diastolic blood pressure; CESC cis rs8067545 0.750 rs4924804 chr17:19991839 C/T cg13482628 chr17:19912719 NA 0.4 5.46 0.32 1.11e-7 Schizophrenia; CESC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg17376030 chr22:41985996 PMM1 0.77 8.31 0.45 4.94e-15 Vitiligo; CESC cis rs7512552 0.839 rs2867894 chr1:150452912 T/A cg15654264 chr1:150340011 RPRD2 0.39 5.2 0.3 3.98e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs10883723 0.810 rs7917525 chr10:104246755 C/G cg22532475 chr10:104410764 TRIM8 -0.33 -5.68 -0.33 3.59e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg19748678 chr4:122722346 EXOSC9 0.77 9.62 0.51 5.51e-19 Type 2 diabetes; CESC cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg23000734 chr10:126850823 CTBP2 -0.53 -8.14 -0.45 1.59e-14 Menarche (age at onset); CESC cis rs9814567 1.000 rs6439487 chr3:134260860 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.15 -0.35 2.87e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg17971929 chr21:40555470 PSMG1 1.0 13.76 0.65 7.15e-33 Cognitive function; CESC cis rs13385 0.769 rs4913073 chr5:139612854 A/G cg26211634 chr5:139558579 C5orf32 0.48 5.24 0.31 3.28e-7 Atrial fibrillation; CESC cis rs9948 0.521 rs61750875 chr2:97359364 A/G cg01990225 chr2:97406019 LMAN2L -0.74 -6.99 -0.39 2.19e-11 Erectile dysfunction and prostate cancer treatment; CESC cis rs59918340 0.764 rs753779 chr8:142228809 T/C cg16341495 chr8:142228727 SLC45A4 -0.44 -5.25 -0.31 3.17e-7 Immature fraction of reticulocytes; CESC cis rs2404602 0.692 rs8037005 chr15:76951109 C/T cg22467129 chr15:76604101 ETFA -0.35 -5.22 -0.31 3.63e-7 Blood metabolite levels; CESC cis rs901683 1.000 rs12779198 chr10:46013547 G/A cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs9303401 0.580 rs12603808 chr17:56578508 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.96 10.8 0.55 9.33e-23 Cognitive test performance; CESC cis rs3741151 1.000 rs61037777 chr11:73046663 A/G cg17517138 chr11:73019481 ARHGEF17 0.61 5.04 0.3 8.58e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs5758659 0.714 rs5758578 chr22:42490292 A/C cg15557168 chr22:42548783 NA 0.44 6.79 0.38 7.38e-11 Cognitive function; CESC cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg04025307 chr7:1156635 C7orf50 0.44 7.13 0.4 9.6e-12 Longevity;Endometriosis; CESC cis rs7586879 0.593 rs11689543 chr2:25130440 A/T cg01884057 chr2:25150051 NA 0.37 7.08 0.4 1.26e-11 Body mass index; CESC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg11663144 chr21:46675770 NA -0.63 -9.96 -0.52 4.67e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10781543 0.839 rs6560632 chr9:139371786 A/C cg14169450 chr9:139327907 INPP5E 0.52 8.08 0.44 2.24e-14 Monocyte percentage of white cells; CESC cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg12311346 chr5:56204834 C5orf35 0.64 8.49 0.46 1.47e-15 Initial pursuit acceleration; CESC cis rs11718455 0.960 rs1852037 chr3:44003720 G/T cg08738300 chr3:44038990 NA -0.44 -5.84 -0.34 1.52e-8 Coronary artery disease; CESC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.03 -0.35 5.41e-9 Developmental language disorder (linguistic errors); CESC cis rs9486719 1.000 rs11756315 chr6:97008678 A/G cg06623918 chr6:96969491 KIAA0776 0.78 8.3 0.45 5.3e-15 Migraine;Coronary artery disease; CESC cis rs4474465 0.646 rs7927503 chr11:78280606 G/T cg01578073 chr11:78285783 NARS2 -0.44 -5.1 -0.3 6.33e-7 Alzheimer's disease (survival time); CESC cis rs4629180 0.959 rs11896771 chr2:102098328 T/C cg01388757 chr2:102091195 RFX8 -0.4 -6.22 -0.36 1.98e-9 Chronic rhinosinusitis with nasal polyps; CESC cis rs3743266 0.507 rs62003261 chr15:60761489 T/C cg22293140 chr15:60689852 ANXA2 -0.7 -7.37 -0.41 2.12e-12 Menarche (age at onset); CESC cis rs763121 0.853 rs5750621 chr22:38956166 C/T cg06022373 chr22:39101656 GTPBP1 0.83 11.89 0.59 2.05e-26 Menopause (age at onset); CESC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg22535103 chr8:58192502 C8orf71 -0.92 -10.16 -0.53 1.04e-20 Developmental language disorder (linguistic errors); CESC cis rs2710642 0.611 rs1527959 chr2:62867413 T/C cg17519650 chr2:63277830 OTX1 0.47 5.54 0.32 7.36e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs4722166 0.598 rs35658589 chr7:22800435 C/A cg05472934 chr7:22766657 IL6 0.4 5.53 0.32 7.51e-8 Lung cancer; CESC cis rs57786342 0.569 rs10139199 chr14:69277800 G/T cg03189333 chr14:69283534 NA -0.43 -5.11 -0.3 6.22e-7 Macrophage inflammatory protein 1a levels; CESC cis rs1847202 0.859 rs13090900 chr3:72946560 C/A cg10804678 chr3:72788309 NA -0.41 -5.42 -0.32 1.31e-7 Motion sickness; CESC cis rs11650494 0.908 rs111834333 chr17:47411814 C/T cg08112188 chr17:47440006 ZNF652 0.99 7.0 0.39 2.13e-11 Prostate cancer; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg15147215 chr3:52552868 STAB1 -0.38 -6.86 -0.39 4.86e-11 Electroencephalogram traits; CESC cis rs3740713 1.000 rs114330751 chr11:18462475 A/G cg23797887 chr11:18477753 LDHAL6A -0.52 -5.05 -0.3 8.21e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs12497850 0.931 rs7431710 chr3:48935583 G/A cg03060546 chr3:49711283 APEH 0.44 5.57 0.32 6.1e-8 Parkinson's disease; CESC cis rs1669338 0.588 rs3864050 chr3:3186769 T/C cg16797762 chr3:3221439 CRBN -0.61 -6.42 -0.37 6.21e-10 White matter integrity; CESC cis rs2370759 0.891 rs11592754 chr10:32619572 A/C cg18270830 chr10:32634957 EPC1 0.65 5.44 0.32 1.19e-7 Sexual dysfunction (female); CESC cis rs3106136 0.967 rs2306802 chr4:95186055 A/G cg11021082 chr4:95130006 SMARCAD1 -0.37 -5.31 -0.31 2.32e-7 Capecitabine sensitivity; CESC cis rs7927592 0.763 rs2513277 chr11:68360887 T/G cg01657329 chr11:68192670 LRP5 -0.47 -6.12 -0.35 3.27e-9 Total body bone mineral density; CESC cis rs74781061 0.722 rs4073149 chr15:74898419 A/G cg17294928 chr15:75287854 SCAMP5 0.52 5.18 0.3 4.39e-7 Endometriosis; CESC cis rs748404 0.660 rs509306 chr15:43715171 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.13 0.45 1.66e-14 Lung cancer; CESC cis rs6545883 0.899 rs12473030 chr2:61720497 T/A cg15711740 chr2:61764176 XPO1 -0.43 -5.39 -0.31 1.54e-7 Tuberculosis; CESC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg19346786 chr7:2764209 NA -0.47 -6.84 -0.39 5.5e-11 Height; CESC cis rs561341 0.714 rs474455 chr17:30312465 A/T cg19193384 chr17:30244184 NA -0.6 -6.4 -0.37 7.11e-10 Hip circumference adjusted for BMI; CESC cis rs2797160 1.000 rs984040 chr6:126021277 A/G cg05901451 chr6:126070800 HEY2 0.43 6.29 0.36 1.3e-9 Endometrial cancer; CESC cis rs1808579 0.935 rs6507720 chr18:21119291 A/G cg14672496 chr18:21087552 C18orf8 0.44 6.7 0.38 1.24e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs4141404 0.673 rs1968023 chr22:31942770 A/G cg00478049 chr22:31556069 RNF185 0.5 5.53 0.32 7.86e-8 Paclitaxel-induced neuropathy; CESC cis rs9287719 0.967 rs10929686 chr2:10743705 A/C cg02196655 chr2:10830764 NOL10 -0.36 -5.61 -0.33 5.2100000000000003e-08 Prostate cancer; CESC cis rs12912251 0.591 rs3102118 chr15:39003475 A/C cg10631289 chr15:39006617 NA -0.49 -5.46 -0.32 1.11e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg14703610 chr5:56206110 C5orf35 0.5 6.64 0.38 1.79e-10 Coronary artery disease; CESC cis rs2479724 0.901 rs2185798 chr6:41773576 G/C cg08135965 chr6:41755394 TOMM6 -0.42 -5.63 -0.33 4.64e-8 Menarche (age at onset); CESC cis rs6835098 0.962 rs6851632 chr4:174109611 A/G cg08422745 chr4:174089978 GALNT7 -0.72 -9.42 -0.5 2.4e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg11644478 chr21:40555479 PSMG1 0.96 13.79 0.65 5.62e-33 Cognitive function; CESC cis rs72781680 0.846 rs72780108 chr2:23986780 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs9457247 0.935 rs2757050 chr6:167377165 G/T cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.62e-7 Crohn's disease; CESC cis rs59918340 0.764 rs4961339 chr8:142231504 A/G cg16341495 chr8:142228727 SLC45A4 -0.44 -5.39 -0.31 1.55e-7 Immature fraction of reticulocytes; CESC cis rs72945132 0.882 rs7950916 chr11:70210001 T/C cg00319359 chr11:70116639 PPFIA1 0.73 6.96 0.39 2.63e-11 Coronary artery disease; CESC cis rs10129255 0.536 rs10139058 chr14:107141916 C/T cg23076370 chr14:107095027 NA -0.53 -7.54 -0.42 7.43e-13 Kawasaki disease; CESC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC cis rs8067545 0.516 rs4925086 chr17:20013459 A/T cg13482628 chr17:19912719 NA 0.41 5.43 0.32 1.3e-7 Schizophrenia; CESC cis rs731174 0.921 rs6686264 chr1:38192337 A/T cg06917450 chr1:38156652 C1orf109 -0.4 -5.29 -0.31 2.56e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs561341 0.769 rs9899093 chr17:30191954 C/G cg19193384 chr17:30244184 NA -0.53 -5.24 -0.31 3.23e-7 Hip circumference adjusted for BMI; CESC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg23978390 chr7:1156363 C7orf50 0.44 5.54 0.32 7.44e-8 Longevity;Endometriosis; CESC cis rs11696501 0.694 rs6073823 chr20:44256910 G/C cg11783356 chr20:44313418 WFDC10B -0.35 -5.4 -0.31 1.49e-7 Brain structure; CESC cis rs9611565 0.512 rs132784 chr22:42052363 G/A cg03806693 chr22:41940476 POLR3H 1.04 12.04 0.59 6.41e-27 Vitiligo; CESC cis rs1832871 0.711 rs9459877 chr6:158692331 G/A cg07165851 chr6:158734300 TULP4 0.58 6.08 0.35 4.11e-9 Height; CESC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg24675658 chr1:53192096 ZYG11B -0.6 -8.14 -0.45 1.52e-14 Monocyte count; CESC cis rs4822044 0.680 rs8138780 chr22:42097462 A/T cg03806693 chr22:41940476 POLR3H 1.13 13.07 0.63 1.86e-30 Cannabis dependence symptom count; CESC cis rs4700695 0.719 rs153390 chr5:65431087 G/C cg21114390 chr5:65439923 SFRS12 -0.48 -5.82 -0.34 1.69e-8 Facial morphology (factor 19); CESC cis rs7666738 0.830 rs35822567 chr4:98654138 G/A cg17366294 chr4:99064904 C4orf37 0.56 7.61 0.42 4.87e-13 Colonoscopy-negative controls vs population controls; CESC cis rs870825 0.616 rs7700216 chr4:185648510 G/T cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs8053891 0.585 rs12926804 chr16:71994932 A/G cg04254540 chr16:71951199 KIAA0174 -0.88 -8.04 -0.44 2.94e-14 Coronary artery disease; CESC trans rs916888 0.610 rs199529 chr17:44837217 A/C cg10053473 chr17:62856997 LRRC37A3 -0.62 -7.71 -0.43 2.49e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg22823121 chr1:150693482 HORMAD1 0.47 6.57 0.37 2.6e-10 Melanoma; CESC cis rs9549367 0.577 rs3024711 chr13:113813268 A/G cg10067723 chr13:113807384 NA -0.43 -5.23 -0.31 3.41e-7 Platelet distribution width; CESC cis rs9811920 0.609 rs9817005 chr3:99682692 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.59 -7.14 -0.4 8.97e-12 Axial length; CESC cis rs6674176 0.628 rs3791116 chr1:44414156 T/A cg13606994 chr1:44402422 ARTN -0.37 -5.51 -0.32 8.35e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9682041 0.696 rs9872796 chr3:170099393 T/G cg11886554 chr3:170076028 SKIL 1.05 8.52 0.46 1.25e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg02297831 chr4:17616191 MED28 0.45 5.47 0.32 1.04e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg00745463 chr17:30367425 LRRC37B -0.86 -7.76 -0.43 1.85e-13 Hip circumference adjusted for BMI; CESC cis rs7116495 0.867 rs612255 chr11:71778664 A/G cg26138937 chr11:71823887 C11orf51 -1.35 -8.41 -0.46 2.63e-15 Severe influenza A (H1N1) infection; CESC trans rs116095464 0.558 rs59113266 chr5:279965 T/C cg00938859 chr5:1591904 SDHAP3 0.65 7.03 0.4 1.73e-11 Breast cancer; CESC cis rs36051895 0.587 rs11999802 chr9:5189773 T/G cg02405213 chr9:5042618 JAK2 -0.48 -5.55 -0.32 6.94e-8 Pediatric autoimmune diseases; CESC cis rs3617 0.625 rs2071042 chr3:52864584 A/G cg07507251 chr3:52567010 NT5DC2 0.32 5.46 0.32 1.1e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs2832191 0.791 rs7282843 chr21:30475226 A/G cg08807101 chr21:30365312 RNF160 0.76 11.01 0.56 1.88e-23 Dental caries; CESC cis rs6089584 0.924 rs6142906 chr20:60552554 G/C cg06108461 chr20:60628389 TAF4 -0.81 -11.84 -0.59 3.09e-26 Body mass index; CESC cis rs9796 0.621 rs1659228 chr15:41471978 A/G cg18705301 chr15:41695430 NDUFAF1 -0.44 -6.44 -0.37 5.52e-10 Menopause (age at onset); CESC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg17650747 chr5:1873721 NA 0.46 6.37 0.36 8.11e-10 Cardiovascular disease risk factors; CESC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg11890956 chr21:40555474 PSMG1 -0.91 -14.42 -0.66 3.48e-35 Cognitive function; CESC cis rs12291225 0.585 rs34171876 chr11:14353957 G/C cg19336497 chr11:14380999 RRAS2 -0.44 -6.61 -0.38 2.13e-10 Sense of smell; CESC cis rs926938 0.527 rs58658580 chr1:115539726 A/G cg12756093 chr1:115239321 AMPD1 0.46 6.32 0.36 1.12e-9 Autism; CESC cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg03433033 chr1:76189801 ACADM 0.73 10.22 0.53 6.96e-21 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.43 0.5 2.17e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7246865 0.859 rs11086052 chr19:17169081 G/A cg19418318 chr19:17219073 MYO9B 0.33 5.43 0.32 1.26e-7 Reticulocyte fraction of red cells; CESC cis rs2073300 0.609 rs6132605 chr20:23354839 A/C cg12062639 chr20:23401060 NAPB 1.03 7.98 0.44 4.32e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05849319 chr11:65172370 FRMD8 -0.55 -6.27 -0.36 1.45e-9 Gut microbiome composition (summer); CESC cis rs7917772 0.582 rs4285804 chr10:104386309 T/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.37 -5.05 -0.3 8.25e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13883366 chr10:29747149 SVIL 0.41 6.15 0.35 2.88e-9 Gut microbiota (bacterial taxa); CESC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg22920501 chr2:26401640 FAM59B -0.86 -10.09 -0.53 1.75e-20 Gut microbiome composition (summer); CESC cis rs1267303 0.642 rs61783087 chr1:46999955 T/C cg25110126 chr1:46999211 NA 1.07 12.0 0.59 8.98e-27 Monobrow; CESC cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg06108461 chr20:60628389 TAF4 0.56 7.52 0.42 8.71e-13 Body mass index; CESC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg04369109 chr6:150039330 LATS1 -0.41 -5.54 -0.32 7.16e-8 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09234025 chr7:6145309 USP42 0.57 6.54 0.37 3.19e-10 Gut microbiome composition (summer); CESC cis rs35110281 0.805 rs2838330 chr21:45023876 T/A cg04455712 chr21:45112962 RRP1B 0.4 5.97 0.34 7.72e-9 Mean corpuscular volume; CESC cis rs7267979 1.000 rs6107045 chr20:25441936 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.83 16.25 0.71 1.14e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs72792276 1.000 rs72794386 chr5:127479278 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.65 5.03 0.3 8.92e-7 Red cell distribution width; CESC cis rs362296 0.671 rs1006798 chr4:3258373 A/G cg08886695 chr4:3369023 RGS12 0.4 5.41 0.32 1.41e-7 Parental longevity (mother's age at death); CESC cis rs4950322 0.857 rs72694703 chr1:146830138 C/A cg22381352 chr1:146742008 CHD1L -0.44 -5.08 -0.3 7.24e-7 Protein quantitative trait loci; CESC cis rs8180040 0.603 rs9854790 chr3:47101306 T/G cg27129171 chr3:47204927 SETD2 0.67 9.83 0.52 1.18e-19 Colorectal cancer; CESC cis rs75804782 0.641 rs3769125 chr2:239349562 A/G cg18131467 chr2:239335373 ASB1 -0.66 -5.83 -0.34 1.58e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs2594989 0.895 rs439738 chr3:11322577 G/C cg00170343 chr3:11313890 ATG7 0.58 5.13 0.3 5.53e-7 Circulating chemerin levels; CESC cis rs8068544 0.818 rs78333491 chr17:40163138 A/G cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.94 -8.43 -0.46 2.27e-15 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs6665290 0.901 rs68087483 chr1:227202668 T/C cg10327440 chr1:227177885 CDC42BPA -1.19 -29.95 -0.88 4.9e-87 Myeloid white cell count; CESC cis rs863345 0.604 rs12133794 chr1:158506697 C/G cg12129480 chr1:158549410 OR10X1 -0.34 -6.78 -0.38 7.87e-11 Pneumococcal bacteremia; CESC cis rs6458375 1.000 rs6458375 chr6:44202352 C/T cg02172915 chr6:44211962 NA 0.46 5.23 0.31 3.38e-7 Interleukin-10 levels; CESC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg02221750 chr19:17393354 ANKLE1 -0.51 -6.2 -0.36 2.19e-9 Systemic lupus erythematosus; CESC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.23 0.41 5.08e-12 Bipolar disorder; CESC cis rs9611565 0.504 rs5758452 chr22:42144927 G/A cg06481639 chr22:41940642 POLR3H 0.5 5.82 0.34 1.71e-8 Vitiligo; CESC trans rs7395662 0.500 rs7951327 chr11:48925359 C/T cg15704280 chr7:45808275 SEPT13 -0.55 -6.69 -0.38 1.32e-10 HDL cholesterol; CESC cis rs9682041 0.696 rs13101192 chr3:170080752 C/G cg11886554 chr3:170076028 SKIL 0.66 6.21 0.36 1.99e-9 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs2933343 0.729 rs6767104 chr3:128648117 G/T cg25356066 chr3:128598488 ACAD9 -0.64 -8.8 -0.48 1.78e-16 IgG glycosylation; CESC cis rs938554 0.513 rs11943372 chr4:9999346 T/A cg11266682 chr4:10021025 SLC2A9 0.45 6.83 0.39 5.72e-11 Blood metabolite levels; CESC cis rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07518170 chr20:30865285 KIF3B -0.43 -5.49 -0.32 9.45e-8 Ulcerative colitis; CESC cis rs8027181 0.682 rs11637168 chr15:73100694 C/A cg25632853 chr15:73088954 NA 0.31 5.69 0.33 3.44e-8 Triglyceride levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16677885 chr7:150778122 FASTK -0.54 -6.21 -0.36 1.99e-9 Gut microbiome composition (summer); CESC cis rs7727544 0.735 rs270605 chr5:131651811 C/T cg07395648 chr5:131743802 NA -0.48 -6.58 -0.37 2.52e-10 Blood metabolite levels; CESC trans rs9364687 0.966 rs4709713 chr6:163800837 G/A cg08378220 chr11:102678779 NA -0.4 -6.27 -0.36 1.46e-9 Body mass index; CESC trans rs877282 0.891 rs11599917 chr10:762288 G/A cg22713356 chr15:30763199 NA 1.16 11.42 0.57 7.89e-25 Uric acid levels; CESC cis rs728616 0.867 rs723193 chr10:81708155 G/T cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg23422044 chr7:1970798 MAD1L1 -0.5 -5.41 -0.32 1.43e-7 Bipolar disorder; CESC cis rs559928 0.606 rs11600628 chr11:63976027 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.64 5.74 0.33 2.56e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs4835473 0.897 rs7678190 chr4:144643574 G/A cg25736465 chr4:144833511 NA 0.39 6.01 0.35 6.07e-9 Immature fraction of reticulocytes; CESC cis rs9611565 0.607 rs132792 chr22:42062822 C/T cg03806693 chr22:41940476 POLR3H 0.73 8.84 0.48 1.38e-16 Vitiligo; CESC cis rs9300255 0.679 rs10772998 chr12:123721177 T/G cg05973401 chr12:123451056 ABCB9 0.5 5.61 0.33 5.11e-8 Neutrophil percentage of white cells; CESC cis rs2273669 0.667 rs9688896 chr6:109364698 T/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs2011503 1.000 rs77254326 chr19:19626781 T/G cg11584989 chr19:19387371 SF4 0.61 7.08 0.4 1.25e-11 Bipolar disorder; CESC cis rs3892630 0.500 rs6510301 chr19:33359791 A/T cg22980127 chr19:33182716 NUDT19 0.79 8.86 0.48 1.15e-16 Red blood cell traits; CESC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg10691866 chr7:65817282 TPST1 0.33 5.55 0.32 6.96e-8 Aortic root size; CESC cis rs559928 0.692 rs876064 chr11:64037033 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.61 5.08 0.3 7.07e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs7809950 1.000 rs2808 chr7:107260856 A/G cg23024343 chr7:107201750 COG5 0.43 5.91 0.34 1.02e-8 Coronary artery disease; CESC trans rs61931739 0.500 rs7133447 chr12:34041901 A/G cg26384229 chr12:38710491 ALG10B 0.5 6.75 0.38 9.3e-11 Morning vs. evening chronotype; CESC cis rs796364 0.906 rs281766 chr2:200820505 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 8.43 0.46 2.18e-15 Schizophrenia; CESC cis rs6570726 0.846 rs6570698 chr6:145918635 C/G cg05347473 chr6:146136440 FBXO30 0.47 6.22 0.36 1.97e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs6460942 0.591 rs62448729 chr7:12333720 G/C cg06484146 chr7:12443880 VWDE -0.66 -7.27 -0.41 4.01e-12 Coronary artery disease; CESC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg11247378 chr22:39784982 NA -0.64 -9.5 -0.5 1.28e-18 Intelligence (multi-trait analysis); CESC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg02935154 chr7:12443704 VWDE -0.57 -7.08 -0.4 1.29e-11 Coronary artery disease; CESC cis rs6496667 0.533 rs886491 chr15:90993215 G/A cg22089800 chr15:90895588 ZNF774 0.45 5.81 0.34 1.75e-8 Rheumatoid arthritis; CESC cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg21138405 chr5:131827807 IRF1 0.38 5.62 0.33 4.76e-8 Breast cancer;Mosquito bite size; CESC cis rs13191362 0.507 rs2510207 chr6:163086592 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.65 -7.55 -0.42 6.82e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3806843 0.931 rs13168670 chr5:140146899 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.38 -0.31 1.65e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg14893161 chr1:205819251 PM20D1 0.45 6.14 0.35 3.06e-9 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.2 -0.3 3.97e-7 Gut microbiome composition (summer); CESC cis rs4629180 0.675 rs10184144 chr2:102104978 C/T cg04415270 chr2:102091202 RFX8 -0.3 -5.35 -0.31 1.86e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs3026101 0.671 rs2871210 chr17:5305027 G/C cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.59 0.32 5.53e-8 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03956680 chr2:64067521 UGP2 0.52 6.88 0.39 4.4e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs57083693 0.518 rs6538981 chr12:101702505 T/C cg22051763 chr12:101673672 UTP20 -0.44 -5.5 -0.32 8.8e-8 Alcohol dependence (age at onset); CESC cis rs8180040 0.620 rs2278963 chr3:47054869 G/T cg27129171 chr3:47204927 SETD2 -0.7 -9.55 -0.51 8.87e-19 Colorectal cancer; CESC cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg17366294 chr4:99064904 C4orf37 0.58 8.25 0.45 7.41e-15 Colonoscopy-negative controls vs population controls; CESC cis rs11638352 1.000 rs8035212 chr15:44304636 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.66 -5.93 -0.34 9.41e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs7100689 0.784 rs7082102 chr10:82104890 A/C cg00277334 chr10:82204260 NA -0.59 -7.75 -0.43 1.95e-13 Post bronchodilator FEV1; CESC cis rs7937682 0.924 rs10891286 chr11:111532691 C/G cg22437258 chr11:111473054 SIK2 0.68 9.21 0.49 1e-17 Primary sclerosing cholangitis; CESC cis rs11123694 1.000 rs11123694 chr2:109064563 C/T cg02082929 chr2:109068933 GCC2 0.51 7.76 0.43 1.91e-13 Mean platelet volume; CESC cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg05234568 chr11:5960015 NA -0.47 -5.53 -0.32 7.54e-8 DNA methylation (variation); CESC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg26338869 chr17:61819248 STRADA 0.69 8.87 0.48 1.09e-16 Prudent dietary pattern; CESC cis rs116095464 0.510 rs7723883 chr5:270798 T/C cg10591111 chr5:226296 SDHA -0.51 -6.27 -0.36 1.45e-9 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15446238 chr11:64037516 BAD 0.6 6.37 0.36 8.09e-10 Gut microbiome composition (summer); CESC cis rs10979 0.679 rs35914889 chr6:143886392 A/T cg25407410 chr6:143891975 LOC285740 -0.54 -7.42 -0.41 1.62e-12 Hypospadias; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01953429 chr4:1367848 KIAA1530 0.45 6.21 0.36 2.05e-9 Fibrinogen levels; CESC cis rs17253792 0.555 rs17683626 chr14:56041112 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.73 0.33 2.76e-8 Putamen volume; CESC cis rs9443645 0.509 rs9361459 chr6:79572922 A/G cg05283184 chr6:79620031 NA 0.37 5.58 0.32 6.03e-8 Intelligence (multi-trait analysis); CESC cis rs7772486 0.790 rs1854900 chr6:146331382 G/A cg05347473 chr6:146136440 FBXO30 0.5 6.51 0.37 3.72e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10781543 0.845 rs10781542 chr9:139327439 A/G cg14019695 chr9:139328340 INPP5E 0.35 5.27 0.31 2.82e-7 Monocyte percentage of white cells; CESC cis rs6060717 0.536 rs6060669 chr20:34480557 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 5.64 0.33 4.31e-8 Hip circumference adjusted for BMI; CESC cis rs9486715 0.758 rs9386528 chr6:96928514 G/A cg18709589 chr6:96969512 KIAA0776 -0.52 -7.01 -0.4 1.92e-11 Headache; CESC cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 9.73 0.51 2.44e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7267979 0.966 rs6037103 chr20:25369095 A/G cg08601574 chr20:25228251 PYGB -0.38 -5.49 -0.32 9.43e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15730116 chr12:76953768 OSBPL8 -0.43 -6.13 -0.35 3.11e-9 Fibrinogen levels; CESC cis rs4568518 0.740 rs12699925 chr7:18010662 G/A cg03009463 chr7:17980271 SNX13 0.46 6.24 0.36 1.69e-9 Measles; CESC cis rs2599510 0.783 rs62136349 chr2:32827504 G/A cg02381751 chr2:32503542 YIPF4 0.45 5.5 0.32 8.74e-8 Interleukin-18 levels; CESC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg11890956 chr21:40555474 PSMG1 1.18 23.93 0.83 3.5e-68 Cognitive function; CESC trans rs853679 0.769 rs17720293 chr6:28214698 C/T cg21479132 chr6:26055353 NA 0.75 6.37 0.36 8.19e-10 Depression; CESC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg10691866 chr7:65817282 TPST1 0.31 5.07 0.3 7.31e-7 Aortic root size; CESC cis rs3026101 0.671 rs3026134 chr17:5309690 G/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs1577917 0.771 rs9362233 chr6:86358247 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -7.02 -0.4 1.9e-11 Response to antipsychotic treatment; CESC cis rs34779708 0.931 rs11010130 chr10:35513307 T/C cg04310649 chr10:35416472 CREM -0.55 -6.38 -0.36 7.93e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs68170813 0.559 rs10953534 chr7:106913718 A/G cg02696742 chr7:106810147 HBP1 0.55 5.68 0.33 3.52e-8 Coronary artery disease; CESC cis rs11155671 0.530 rs9397420 chr6:150206781 C/T cg09699651 chr6:150184138 LRP11 -0.51 -7.05 -0.4 1.51e-11 Testicular germ cell tumor; CESC cis rs1665050 0.534 rs4465553 chr15:59246820 C/T cg05156742 chr15:59063176 FAM63B 0.47 6.0 0.35 6.49e-9 Atopic dermatitis; CESC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.54 8.08 0.44 2.26e-14 Bipolar disorder; CESC trans rs877282 0.945 rs11599043 chr10:777972 C/T cg22713356 chr15:30763199 NA 1.24 12.93 0.62 5.55e-30 Uric acid levels; CESC cis rs71277158 0.688 rs16854875 chr3:169899667 T/G cg04067573 chr3:169899625 PHC3 0.72 6.92 0.39 3.34e-11 Prostate cancer; CESC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg25272121 chr1:152190972 HRNR -0.41 -5.99 -0.35 6.78e-9 Inflammatory skin disease; CESC cis rs12050794 0.671 rs8192362 chr15:72519858 G/A cg16672083 chr15:72433130 SENP8 0.46 6.84 0.39 5.41e-11 Metabolite levels (HVA/MHPG ratio); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17446216 chr1:32480239 KHDRBS1 -0.44 -6.28 -0.36 1.42e-9 Gut microbiota (bacterial taxa); CESC cis rs1624802 0.966 rs1707933 chr12:130497813 T/G cg15444478 chr12:130494697 NA -0.27 -5.4 -0.32 1.45e-7 Obesity-related traits; CESC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg25934064 chr3:52569026 NT5DC2 0.29 5.85 0.34 1.48e-8 Electroencephalogram traits; CESC cis rs8016982 0.633 rs8015423 chr14:81719357 C/T cg01989461 chr14:81687754 GTF2A1 0.71 11.1 0.56 9.2e-24 Schizophrenia; CESC cis rs2276314 0.857 rs62101393 chr18:33592168 T/C cg05985134 chr18:33552581 C18orf21 0.61 7.33 0.41 2.8e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs2380220 0.720 rs9400397 chr6:95980623 C/A cg15832292 chr6:96025679 MANEA 0.62 6.87 0.39 4.62e-11 Behavioural disinhibition (generation interaction); CESC cis rs4319547 0.728 rs61954974 chr12:123074169 T/C cg23029597 chr12:123009494 RSRC2 -0.49 -5.41 -0.32 1.41e-7 Body mass index; CESC cis rs2070488 0.965 rs7433277 chr3:38529818 C/T cg24069376 chr3:38537580 EXOG 0.49 8.96 0.48 5.98e-17 Electrocardiographic conduction measures; CESC cis rs9467711 0.606 rs68112369 chr6:26365759 T/C cg14345882 chr6:26364793 BTN3A2 0.6 6.14 0.35 3.01e-9 Autism spectrum disorder or schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00529053 chr6:158589440 GTF2H5;SERAC1 0.44 6.06 0.35 4.72e-9 Gut microbiota (bacterial taxa); CESC cis rs7267979 0.932 rs417110 chr20:25458297 T/C cg08601574 chr20:25228251 PYGB 0.37 5.36 0.31 1.77e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg09699651 chr6:150184138 LRP11 0.4 5.08 0.3 7.22e-7 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23236025 chr1:109826094 PSRC1 0.62 6.84 0.39 5.48e-11 Gut microbiome composition (summer); CESC cis rs7216064 1.000 rs8081517 chr17:65845697 A/T cg12091567 chr17:66097778 LOC651250 -0.81 -9.14 -0.49 1.72e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs853679 0.546 rs200995 chr6:27813694 C/T cg06606381 chr12:133084897 FBRSL1 0.77 7.61 0.42 4.87e-13 Depression; CESC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg18446336 chr7:2847575 GNA12 -0.39 -5.93 -0.34 9.49e-9 Height; CESC cis rs71277158 0.688 rs17471922 chr3:169779394 A/G cg04067573 chr3:169899625 PHC3 0.65 6.57 0.37 2.59e-10 Prostate cancer; CESC cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg11502198 chr6:26597334 ABT1 -0.48 -6.88 -0.39 4.26e-11 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09972077 chr17:57232291 SKA2;PRR11 0.63 7.0 0.4 2.14e-11 Gut microbiome composition (summer); CESC cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg03433033 chr1:76189801 ACADM 0.62 6.34 0.36 9.58e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6502050 0.835 rs11654584 chr17:80079435 A/T cg23985595 chr17:80112537 CCDC57 -0.4 -6.14 -0.35 3.01e-9 Life satisfaction; CESC cis rs4969178 0.896 rs12602206 chr17:76397133 A/G cg05887092 chr17:76393375 PGS1 0.58 9.2 0.49 1.13e-17 HDL cholesterol levels; CESC cis rs244293 0.730 rs12951898 chr17:53035602 C/T cg19360675 chr17:53046073 COX11;STXBP4 -0.48 -6.63 -0.38 1.83e-10 Menarche (age at onset); CESC cis rs4727963 0.869 rs10262500 chr7:122799737 C/T cg03640110 chr7:122635026 TAS2R16 0.34 5.16 0.3 4.86e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg14797243 chr11:68671428 IGHMBP2;MRPL21 0.47 6.02 0.35 5.93e-9 Obesity-related traits; CESC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.67 -8.57 -0.47 8.66e-16 Mean platelet volume; CESC cis rs11690935 0.838 rs10432423 chr2:172753295 G/A cg13550731 chr2:172543902 DYNC1I2 -0.85 -12.52 -0.61 1.46e-28 Schizophrenia; CESC cis rs3733585 0.806 rs7375599 chr4:9954918 C/T cg02734326 chr4:10020555 SLC2A9 0.44 6.61 0.38 2.11e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2625529 0.824 rs7170754 chr15:72218594 G/A cg16672083 chr15:72433130 SENP8 -0.39 -5.06 -0.3 7.68e-7 Red blood cell count; CESC trans rs4349753 0.640 rs28509278 chr5:144088800 C/T cg22407458 chr6:35109121 TCP11 0.51 6.4 0.37 7e-10 Photic sneeze reflex; CESC cis rs7264396 0.635 rs6060673 chr20:34482396 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.77 10.38 0.54 2.04e-21 Total cholesterol levels; CESC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.31 -5.11 -0.3 6.27e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs56313388 0.793 rs9937815 chr16:56330832 C/T cg02433656 chr16:56322654 GNAO1 -0.44 -5.59 -0.32 5.6e-8 Pulse pressure; CESC cis rs990171 0.607 rs2192752 chr2:102769373 A/C cg22835712 chr2:102737379 NA -0.44 -5.96 -0.34 7.99e-9 Lymphocyte counts; CESC cis rs863345 0.604 rs7514968 chr1:158493852 A/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.75e-11 Pneumococcal bacteremia; CESC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg25072359 chr17:41440525 NA 0.45 6.07 0.35 4.5e-9 Menopause (age at onset); CESC cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg25405998 chr7:65216604 CCT6P1 0.49 5.22 0.31 3.57e-7 Aortic root size; CESC cis rs290268 1.000 rs290274 chr9:93546913 C/T cg02608019 chr9:93564028 SYK 0.63 9.36 0.5 3.47e-18 Platelet count; CESC cis rs7917772 0.582 rs10786685 chr10:104323103 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 5.59 0.32 5.57e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7786808 0.653 rs7810861 chr7:158212633 G/A cg01191920 chr7:158217561 PTPRN2 -0.31 -5.17 -0.3 4.67e-7 Obesity-related traits; CESC cis rs3857536 0.813 rs7743965 chr6:66941346 C/G cg07460842 chr6:66804631 NA -0.41 -5.28 -0.31 2.71e-7 Blood trace element (Cu levels); CESC cis rs703842 0.575 rs701006 chr12:58106836 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.41 5.27 0.31 2.89e-7 Multiple sclerosis; CESC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg14393609 chr7:65229607 NA 0.52 7.08 0.4 1.28e-11 Aortic root size; CESC cis rs12474201 0.894 rs34401107 chr2:46972768 A/C cg06386533 chr2:46925753 SOCS5 0.89 12.27 0.6 1.07e-27 Height; CESC cis rs1364705 0.955 rs12677274 chr8:120222541 C/T cg09273054 chr8:120220131 MAL2 -0.63 -7.23 -0.41 5.13e-12 Hippocampal atrophy; CESC cis rs7044106 0.762 rs4837790 chr9:123446325 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 12.82 0.62 1.3e-29 Hip circumference adjusted for BMI; CESC cis rs8060686 0.545 rs55897859 chr16:68286748 G/C cg26727032 chr16:67993705 SLC12A4 -0.51 -5.35 -0.31 1.94e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs10752881 1.000 rs10752886 chr1:182987248 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.79e-31 Colorectal cancer; CESC cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg08917208 chr2:24149416 ATAD2B 0.6 5.66 0.33 3.99e-8 Lymphocyte counts; CESC cis rs1467026 0.606 rs9814180 chr3:12818386 A/G cg24848339 chr3:12840334 CAND2 0.43 6.79 0.38 7.49e-11 P wave duration; CESC cis rs1348850 0.846 rs4893962 chr2:178421106 A/G cg22681709 chr2:178499509 PDE11A -0.38 -5.73 -0.33 2.76e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6546537 0.824 rs3771543 chr2:69784255 C/T cg10773587 chr2:69614142 GFPT1 -0.63 -7.77 -0.43 1.78e-13 Serum thyroid-stimulating hormone levels; CESC cis rs4642101 0.793 rs6799179 chr3:12829095 A/C cg05775895 chr3:12838266 CAND2 0.35 5.28 0.31 2.72e-7 QRS complex (12-leadsum); CESC cis rs75477785 1.000 rs11119359 chr1:210054435 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.81 5.37 0.31 1.69e-7 Cleft lip with or without cleft palate; CESC cis rs61931739 0.500 rs10844845 chr12:34381117 C/T cg06521331 chr12:34319734 NA -0.36 -5.06 -0.3 8.03e-7 Morning vs. evening chronotype; CESC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg11663144 chr21:46675770 NA -0.53 -7.18 -0.4 6.99e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg12463550 chr7:65579703 CRCP -0.47 -6.11 -0.35 3.6e-9 Aortic root size; CESC cis rs7149337 1.000 rs35567150 chr14:51725944 A/G cg23942311 chr14:51606299 NA 0.44 7.32 0.41 2.92e-12 Cancer; CESC cis rs863345 0.604 rs2051451 chr1:158464265 A/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs854765 0.693 rs9907287 chr17:17774118 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.61 -9.02 -0.48 3.99e-17 Total body bone mineral density; CESC cis rs3820068 0.581 rs16849152 chr1:15921774 A/C cg16988262 chr1:15930761 NA 0.35 5.58 0.32 5.86e-8 Systolic blood pressure; CESC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg22800045 chr5:56110881 MAP3K1 -0.6 -7.76 -0.43 1.79e-13 Initial pursuit acceleration; CESC cis rs13056815 1 rs13056815 chr22:31668250 G/A cg25791279 chr22:32026902 PISD -0.46 -5.46 -0.32 1.08e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1775715 0.870 rs1419168 chr10:32257332 A/C cg04359828 chr10:32216031 ARHGAP12 0.36 5.31 0.31 2.29e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs2204008 0.774 rs11495520 chr12:38060605 T/G cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg16384552 chr7:74938386 SPDYE8P -0.43 -5.47 -0.32 1.03e-7 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs710216 0.957 rs3806401 chr1:43426212 G/T cg03128534 chr1:43423976 SLC2A1 -0.53 -5.61 -0.33 5.07e-8 Red cell distribution width; CESC cis rs72781680 0.665 rs2953028 chr2:24068126 T/C cg08917208 chr2:24149416 ATAD2B 0.63 6.28 0.36 1.41e-9 Lymphocyte counts; CESC cis rs2243480 0.803 rs34004500 chr7:65312178 A/T cg13147721 chr7:65941812 NA -0.85 -8.51 -0.46 1.26e-15 Diabetic kidney disease; CESC cis rs35740288 0.571 rs11633790 chr15:86326370 G/A cg20737812 chr15:86336631 KLHL25 -0.42 -5.2 -0.3 3.9e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs12477438 0.798 rs9679602 chr2:99577827 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.74 10.52 0.54 7.26e-22 Chronic sinus infection; CESC cis rs8141529 0.748 rs1318025 chr22:29283757 C/T cg15103426 chr22:29168792 CCDC117 0.61 7.81 0.43 1.31e-13 Lymphocyte counts; CESC cis rs5769765 0.955 rs2319465 chr22:50265784 A/C cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs4319547 1.000 rs6489157 chr12:123101673 C/G cg05707623 chr12:122985044 ZCCHC8 0.59 7.1 0.4 1.15e-11 Body mass index; CESC cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg14784868 chr12:69753453 YEATS4 0.83 12.99 0.62 3.36e-30 Blood protein levels; CESC cis rs11122272 0.735 rs2572251 chr1:231514243 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg25405998 chr7:65216604 CCT6P1 0.48 5.32 0.31 2.16e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07472772 chr20:31071948 C20orf112 0.55 6.44 0.37 5.44e-10 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7605827 0.930 rs12995776 chr2:15717131 T/A cg19274914 chr2:15703543 NA 0.34 6.0 0.35 6.52e-9 Educational attainment (years of education); CESC cis rs17253792 0.822 rs78429067 chr14:56092551 G/A cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs4969178 0.965 rs3744217 chr17:76400258 G/A cg20026190 chr17:76395443 PGS1 0.46 7.35 0.41 2.41e-12 HDL cholesterol levels; CESC cis rs796364 1.000 rs281785 chr2:200749566 A/G cg23649088 chr2:200775458 C2orf69 0.55 5.07 0.3 7.6e-7 Schizophrenia; CESC cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs34779708 0.931 rs2505631 chr10:35368385 A/T cg03585969 chr10:35415529 CREM -0.74 -9.75 -0.51 2.16e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg12193833 chr17:30244370 NA -0.76 -6.94 -0.39 2.92e-11 Hip circumference adjusted for BMI; CESC cis rs5750830 0.594 rs5757648 chr22:39775156 G/A cg02038168 chr22:39784481 NA -0.56 -7.35 -0.41 2.5e-12 Intelligence (multi-trait analysis); CESC cis rs9399135 0.838 rs4896126 chr6:135342786 C/A cg24558204 chr6:135376177 HBS1L 0.52 7.29 0.41 3.48e-12 Red blood cell count; CESC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.57 6.8 0.39 6.84e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs854765 0.663 rs12941550 chr17:17753828 C/A cg09796270 chr17:17721594 SREBF1 -0.45 -6.5 -0.37 3.89e-10 Total body bone mineral density; CESC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.63e-16 Initial pursuit acceleration; CESC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg10295955 chr4:187884368 NA -1.03 -20.74 -0.79 1.94e-57 Lobe attachment (rater-scored or self-reported); CESC cis rs10979 1.000 rs9285500 chr6:143897614 G/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs17666538 0.585 rs336437 chr8:636251 A/C cg07234876 chr8:600039 NA 0.78 5.78 0.33 2.11e-8 IgG glycosylation; CESC cis rs7219021 0.674 rs11656939 chr17:46964406 G/C cg16584676 chr17:46985605 UBE2Z -0.65 -7.82 -0.43 1.24e-13 Schizophrenia or bipolar disorder; CESC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.6 0.64 2.58e-32 Prudent dietary pattern; CESC cis rs846111 1.000 rs846111 chr1:6279370 G/C cg02892189 chr1:6321676 GPR153 -0.55 -7.16 -0.4 8.18e-12 QT interval; CESC cis rs3857536 0.776 rs4710583 chr6:66940101 A/C cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs9814567 1.000 rs9289476 chr3:134237103 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.82 -0.34 1.68e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs854765 0.551 rs56886154 chr17:17831473 C/A cg16928487 chr17:17741425 SREBF1 -0.59 -10.25 -0.53 5.56e-21 Total body bone mineral density; CESC cis rs7953508 0.506 rs2053196 chr12:93962959 T/C cg18151635 chr12:93972918 NA -0.44 -5.85 -0.34 1.41e-8 Pubertal anthropometrics; CESC cis rs1355223 1.000 rs1355222 chr11:34758716 C/G cg11058730 chr11:34937778 PDHX;APIP -0.46 -5.97 -0.34 7.75e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9902453 0.716 rs3098949 chr17:27978694 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 9.76 0.51 1.98e-19 Coffee consumption (cups per day); CESC cis rs7208859 0.573 rs73267829 chr17:29003939 G/A cg19761014 chr17:28927070 LRRC37B2 0.82 6.73 0.38 1.02e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7296418 0.922 rs1790134 chr12:123697898 T/C cg05973401 chr12:123451056 ABCB9 0.51 6.52 0.37 3.49e-10 Platelet count; CESC cis rs1355223 0.506 rs11032894 chr11:34865544 T/C cg11058730 chr11:34937778 PDHX;APIP -0.54 -6.72 -0.38 1.12e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2304069 1.000 rs10072275 chr5:149401596 T/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.91 11.52 0.58 3.72e-25 HIV-1 control; CESC cis rs2797160 1.000 rs1739363 chr6:126020980 G/A cg05901451 chr6:126070800 HEY2 0.44 6.32 0.36 1.13e-9 Endometrial cancer; CESC cis rs7833986 0.501 rs2953897 chr8:56980569 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 6.89e-13 Height; CESC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.11 0.53 1.56e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7772486 0.790 rs2250387 chr6:146205233 C/T cg23711669 chr6:146136114 FBXO30 0.92 13.5 0.64 5.99e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs7617773 0.780 rs3731550 chr3:48206583 A/C cg11946769 chr3:48343235 NME6 0.88 11.47 0.58 5.58e-25 Coronary artery disease; CESC cis rs34375054 0.624 rs7295689 chr12:125680922 T/G cg25124228 chr12:125621409 AACS -0.5 -5.76 -0.33 2.28e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg00750074 chr16:89608354 SPG7 -0.41 -6.02 -0.35 5.83e-9 Multiple myeloma (IgH translocation); CESC cis rs5753618 0.583 rs2899164 chr22:31790289 G/A cg02404636 chr22:31891804 SFI1 0.4 5.41 0.32 1.42e-7 Colorectal cancer; CESC cis rs6740322 1.000 rs4128209 chr2:43554729 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.59 -6.47 -0.37 4.64e-10 Coronary artery disease; CESC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg08470875 chr2:26401718 FAM59B -0.62 -6.6 -0.38 2.28e-10 Gut microbiome composition (summer); CESC cis rs524281 0.773 rs2155201 chr11:65992344 T/C cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.38e-7 Electroencephalogram traits; CESC cis rs7107174 0.892 rs2510042 chr11:77923665 C/T cg02023728 chr11:77925099 USP35 0.49 6.56 0.37 2.89e-10 Testicular germ cell tumor; CESC cis rs7851660 0.809 rs10739526 chr9:100662671 T/C cg13688889 chr9:100608707 NA -0.62 -8.87 -0.48 1.11e-16 Strep throat; CESC cis rs258892 0.895 rs13181437 chr5:72051657 G/A cg21869765 chr5:72125136 TNPO1 -0.4 -5.26 -0.31 2.97e-7 Small cell lung carcinoma; CESC cis rs67311347 0.544 rs7644643 chr3:40350209 C/T cg09455208 chr3:40491958 NA -0.35 -6.15 -0.35 2.77e-9 Renal cell carcinoma; CESC cis rs1267303 0.636 rs1267310 chr1:46987307 A/T cg25110126 chr1:46999211 NA -0.72 -8.88 -0.48 1.04e-16 Monobrow; CESC cis rs6546550 0.901 rs3732266 chr2:70057448 T/G cg02498382 chr2:70120550 SNRNP27 -0.38 -6.4 -0.37 7.17e-10 Prevalent atrial fibrillation; CESC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg23978390 chr7:1156363 C7orf50 0.65 9.08 0.49 2.53e-17 Longevity;Endometriosis; CESC trans rs9329221 0.905 rs17765901 chr8:10249480 G/T cg15556689 chr8:8085844 FLJ10661 -0.52 -6.0 -0.35 6.6e-9 Neuroticism; CESC cis rs453301 0.686 rs1045527 chr8:8890041 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -6.0 -0.35 6.44e-9 Joint mobility (Beighton score); CESC cis rs8062405 0.723 rs12445744 chr16:28588395 A/C cg07382826 chr16:28625726 SULT1A1 0.4 6.58 0.37 2.54e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2439831 0.850 rs12441984 chr15:44126285 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.6 0.42 4.99e-13 Lung cancer in ever smokers; CESC cis rs7829975 0.517 rs12542733 chr8:8824858 G/T cg15556689 chr8:8085844 FLJ10661 -0.44 -5.51 -0.32 8.58e-8 Mood instability; CESC cis rs1152591 0.967 rs1152589 chr14:64683926 A/T cg21174375 chr14:64681225 SYNE2 -0.47 -6.32 -0.36 1.1e-9 Atrial fibrillation; CESC cis rs7017914 0.934 rs13274062 chr8:71737087 G/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.44 -5.68 -0.33 3.58e-8 Bone mineral density; CESC cis rs2519796 0.564 rs2519799 chr9:136810857 A/G cg13751417 chr9:136814406 VAV2 0.41 5.35 0.31 1.88e-7 Hematocrit;Hemoglobin concentration; CESC cis rs1348850 0.645 rs10164417 chr2:178444130 A/G cg23306229 chr2:178417860 TTC30B 0.66 7.1 0.4 1.14e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg04317338 chr11:64019027 PLCB3 0.9 9.36 0.5 3.64e-18 Mean platelet volume; CESC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg15813090 chr5:442598 EXOC3;C5orf55 0.43 6.43 0.37 6.03e-10 Cystic fibrosis severity; CESC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg26314531 chr2:26401878 FAM59B -0.66 -7.68 -0.43 3.17e-13 Gut microbiome composition (summer); CESC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg09177884 chr7:1199841 ZFAND2A -0.54 -6.12 -0.35 3.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs728616 0.681 rs55855057 chr10:82034729 G/A cg05935833 chr10:81318306 SFTPA2 -0.45 -5.78 -0.33 2.1e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg05863683 chr7:1912471 MAD1L1 0.43 6.62 0.38 2e-10 Bipolar disorder and schizophrenia; CESC cis rs41308713 0.681 rs8116426 chr20:37034643 A/C cg09132763 chr20:37064059 LOC388796;SNORA71D 1.13 6.51 0.37 3.77e-10 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs7818688 0.697 rs11782818 chr8:95978221 A/G cg16049864 chr8:95962084 TP53INP1 0.57 5.74 0.33 2.65e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs17253792 0.822 rs75437558 chr14:56066798 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.83 6.18 0.36 2.36e-9 Putamen volume; CESC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg09509183 chr1:209979624 IRF6 0.52 6.24 0.36 1.72e-9 Cleft lip with or without cleft palate; CESC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg15052019 chr19:19431593 KIAA0892;SF4 -0.42 -5.39 -0.31 1.53e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19942813 chr3:187463496 BCL6 0.57 6.55 0.37 2.98e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs13204280 chr6:146415368 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.72 0.38 1.14e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2730245 0.661 rs842696 chr7:158662698 T/C cg01943577 chr7:158741284 NA -0.46 -6.07 -0.35 4.5e-9 Height; CESC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg19468946 chr17:37922297 IKZF3 -0.39 -5.09 -0.3 6.9e-7 Glomerular filtration rate (creatinine); CESC trans rs10242455 0.702 rs73713521 chr7:99188649 G/A cg09045935 chr12:6379348 NA 0.93 6.94 0.39 3.02e-11 Blood metabolite levels; CESC cis rs9513593 0.901 rs7997943 chr13:99810343 T/C cg21788972 chr13:99853209 UBAC2 0.47 5.62 0.33 4.73e-8 Psoriasis; CESC cis rs2708240 0.936 rs2538981 chr7:147582251 A/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -6.02 -0.35 5.89e-9 QT interval (drug interaction); CESC cis rs67311347 1.000 rs9841335 chr3:40475858 G/A cg24209194 chr3:40518798 ZNF619 0.46 5.99 0.35 6.9e-9 Renal cell carcinoma; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01043383 chr19:57630742 USP29 -0.46 -6.08 -0.35 4.26e-9 Intelligence (multi-trait analysis); CESC cis rs7223966 0.960 rs2854222 chr17:61939015 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.9 0.39 3.94e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7208859 0.623 rs73263788 chr17:29216490 T/C cg19761014 chr17:28927070 LRRC37B2 0.63 5.32 0.31 2.26e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1499614 1.000 rs2707840 chr7:66158015 C/T cg12463550 chr7:65579703 CRCP 0.74 5.75 0.33 2.47e-8 Gout; CESC cis rs7586879 0.639 rs2033656 chr2:25100902 C/G cg01884057 chr2:25150051 NA 0.36 6.89 0.39 3.95e-11 Body mass index; CESC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.03 10.9 0.56 4.11e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7267979 1.000 rs1888997 chr20:25298988 G/A cg08601574 chr20:25228251 PYGB -0.37 -5.24 -0.31 3.3e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs847577 0.609 rs34320230 chr7:97785500 C/T cg21770322 chr7:97807741 LMTK2 0.83 13.85 0.65 3.33e-33 Breast cancer; CESC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg07677032 chr17:61819896 STRADA 0.45 5.95 0.34 8.6e-9 Prudent dietary pattern; CESC cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.6 0.47 7.1e-16 Colonoscopy-negative controls vs population controls; CESC trans rs17685 0.712 rs10275521 chr7:75770972 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.41 0.61 3.51e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.87e-17 Tonsillectomy; CESC cis rs10089 1.000 rs4836370 chr5:127499224 A/G cg19767477 chr5:127420684 SLC12A2 -0.39 -5.26 -0.31 2.96e-7 Ileal carcinoids; CESC cis rs9457247 0.646 rs4710160 chr6:167409241 T/A cg23791538 chr6:167370224 RNASET2 -0.61 -8.81 -0.48 1.71e-16 Crohn's disease; CESC cis rs10242455 0.681 rs1851425 chr7:99300231 G/A cg07715041 chr7:99302981 CYP3A7 -0.44 -5.56 -0.32 6.73e-8 Blood metabolite levels; CESC cis rs7267979 1.000 rs6050631 chr20:25431749 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 16.43 0.71 2.68e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs9291683 0.561 rs3733584 chr4:10036506 T/C cg02734326 chr4:10020555 SLC2A9 0.49 6.84 0.39 5.6e-11 Bone mineral density; CESC cis rs3096299 0.617 rs2353030 chr16:89405827 C/T cg02187348 chr16:89574699 SPG7 -0.48 -6.18 -0.35 2.44e-9 Multiple myeloma (IgH translocation); CESC cis rs8092503 1.000 rs12454336 chr18:52497204 C/T cg12377874 chr18:52495404 RAB27B -0.36 -6.08 -0.35 4.29e-9 Childhood body mass index; CESC cis rs11574514 1.000 rs1107767 chr16:68020063 C/G cg01866162 chr16:67596514 CTCF 0.97 5.6 0.33 5.22e-8 Crohn's disease; CESC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.07 -0.3 7.42e-7 Total body bone mineral density; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg13986503 chr11:126152983 TIRAP -0.44 -6.16 -0.35 2.63e-9 Recombination measurement; CESC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg16325326 chr1:53192061 ZYG11B -0.88 -15.0 -0.68 3.14e-37 Monocyte count; CESC cis rs6665290 0.901 rs61834004 chr1:227202782 G/A cg10327440 chr1:227177885 CDC42BPA -1.18 -28.43 -0.87 1.81e-82 Myeloid white cell count; CESC cis rs8071756 1.000 rs62089969 chr17:1575196 T/C ch.17.72133F chr17:1577994 PRPF8 0.49 5.23 0.31 3.4e-7 Blood protein levels; CESC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg18230493 chr5:56204884 C5orf35 -0.73 -8.61 -0.47 6.69e-16 Initial pursuit acceleration; CESC cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.0 0.39 2.15e-11 Colorectal cancer; CESC cis rs6487679 0.526 rs972111 chr12:9374373 A/G cg08997352 chr12:9597637 DDX12 -0.5 -5.48 -0.32 1.01e-7 Non-alcoholic fatty liver disease histology (AST); CESC cis rs2933343 0.729 rs813732 chr3:128619357 C/T cg11901034 chr3:128598214 ACAD9 -0.37 -5.35 -0.31 1.94e-7 IgG glycosylation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25464034 chr11:450264 PTDSS2 0.5 7.06 0.4 1.47e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10751667 1.000 rs6597972 chr11:928402 C/T cg01483505 chr11:975446 AP2A2 0.41 5.45 0.32 1.13e-7 Alzheimer's disease (late onset); CESC cis rs3820928 0.934 rs60141402 chr2:227761445 A/C cg05526886 chr2:227700861 RHBDD1 -0.42 -5.5 -0.32 8.95e-8 Pulmonary function; CESC cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg22307029 chr19:49891270 CCDC155 0.54 5.9 0.34 1.1e-8 Multiple sclerosis; CESC cis rs1267303 0.675 rs1267313 chr1:46986322 G/T cg25110126 chr1:46999211 NA -0.72 -8.95 -0.48 6.36e-17 Monobrow; CESC cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19473056 chr3:41996898 ULK4 -0.58 -6.36 -0.36 9.03e-10 Gut microbiome composition (summer); CESC cis rs2635047 0.682 rs7242976 chr18:44797159 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.07 0.3 7.62e-7 Educational attainment; CESC cis rs7903847 0.642 rs10882922 chr10:99158537 C/T cg20016023 chr10:99160130 RRP12 -0.3 -5.19 -0.3 4.18e-7 Granulocyte percentage of myeloid white cells; CESC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.26 -0.31 2.94e-7 Gut microbiome composition (summer); CESC cis rs9815354 0.680 rs73073296 chr3:42028074 G/A cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs9902453 0.753 rs3097118 chr17:27978466 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.19 0.53 8.39e-21 Coffee consumption (cups per day); CESC cis rs4604732 0.631 rs4436425 chr1:247632323 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 5.4 0.31 1.47e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg07636037 chr3:49044803 WDR6 1.02 18.48 0.75 1.47e-49 Parkinson's disease; CESC cis rs17039065 1.000 rs72889396 chr4:109400426 T/A cg16022748 chr4:109541635 LOC285456;RPL34 0.66 5.49 0.32 9.29e-8 Gut microbiome composition (summer); CESC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg08736216 chr1:53307985 ZYG11A -0.38 -6.16 -0.35 2.68e-9 Monocyte count; CESC cis rs317689 0.918 rs610192 chr12:69739941 T/C cg14784868 chr12:69753453 YEATS4 0.61 6.8 0.39 7.01e-11 Response to diuretic therapy; CESC cis rs7147624 1.000 rs7150233 chr14:66200816 A/G cg03016385 chr14:66212404 NA -0.52 -5.09 -0.3 6.81e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 10.3 0.53 3.89e-21 Eosinophil percentage of white cells; CESC cis rs7107174 1.000 rs6592772 chr11:78015563 A/C cg02023728 chr11:77925099 USP35 0.48 6.26 0.36 1.51e-9 Testicular germ cell tumor; CESC cis rs2115630 0.645 rs2292463 chr15:85175750 A/G cg12501888 chr15:85177176 SCAND2 -0.45 -5.99 -0.35 6.69e-9 P wave terminal force; CESC cis rs6598955 0.724 rs869683 chr1:26570993 T/A cg04990556 chr1:26633338 UBXN11 -0.75 -10.61 -0.55 3.68e-22 Obesity-related traits; CESC cis rs17376456 0.825 rs17372725 chr5:93135588 C/A cg21475434 chr5:93447410 FAM172A 0.8 7.22 0.41 5.48e-12 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18970754 chr14:74079533 NA 0.52 6.15 0.35 2.81e-9 Gut microbiome composition (summer); CESC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg12463550 chr7:65579703 CRCP 0.49 6.27 0.36 1.48e-9 Aortic root size; CESC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg26314531 chr2:26401878 FAM59B -0.62 -6.99 -0.39 2.29e-11 Gut microbiome composition (summer); CESC cis rs4803468 1.000 rs2231940 chr19:41944237 T/C cg14132834 chr19:41945861 ATP5SL 0.66 8.19 0.45 1.09e-14 Height; CESC cis rs3126085 0.778 rs10788828 chr1:152191879 G/A cg26876637 chr1:152193138 HRNR 0.48 5.5 0.32 8.93e-8 Atopic dermatitis; CESC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg11764359 chr7:65958608 NA 0.71 9.46 0.5 1.77e-18 Aortic root size; CESC cis rs9487051 0.676 rs9374077 chr6:109600194 C/T cg21918786 chr6:109611834 NA -0.37 -5.5 -0.32 9.15e-8 Reticulocyte fraction of red cells; CESC cis rs11229555 0.609 rs12575080 chr11:58224917 A/G cg15696309 chr11:58395628 NA -0.45 -5.22 -0.31 3.63e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs4243830 0.850 rs3761927 chr1:6601773 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.99 -10.01 -0.52 3.22e-20 Body mass index; CESC trans rs1728785 1.000 rs1749793 chr16:68569312 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.39 0.41 1.91e-12 Ulcerative colitis; CESC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg23708337 chr7:1209742 NA 0.5 5.42 0.32 1.32e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg18099408 chr3:52552593 STAB1 -0.33 -5.34 -0.31 2.02e-7 Bipolar disorder; CESC cis rs7188697 0.922 rs37039 chr16:58578091 C/T cg02549819 chr16:58548995 SETD6 -0.42 -5.29 -0.31 2.55e-7 QT interval; CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg17372223 chr3:52568218 NT5DC2 0.52 8.76 0.47 2.32e-16 Electroencephalogram traits; CESC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg18402987 chr7:1209562 NA 0.59 7.0 0.4 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2294693 0.891 rs1072119 chr6:40993072 G/A cg14769373 chr6:40998127 UNC5CL -0.47 -6.37 -0.36 8.3e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg08470875 chr2:26401718 FAM59B -0.48 -5.32 -0.31 2.21e-7 Gut microbiome composition (summer); CESC cis rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg00409905 chr10:38381863 ZNF37A -0.45 -6.21 -0.36 2.04e-9 Extrinsic epigenetic age acceleration; CESC cis rs7666738 0.515 rs10015315 chr4:98700137 A/G cg17366294 chr4:99064904 C4orf37 0.53 6.7 0.38 1.27e-10 Colonoscopy-negative controls vs population controls; CESC cis rs9393777 0.513 rs6924727 chr6:26491234 A/G cg12826209 chr6:26865740 GUSBL1 0.59 6.91 0.39 3.52e-11 Intelligence (multi-trait analysis); CESC cis rs9325144 0.647 rs3759139 chr12:39087609 G/A cg26384229 chr12:38710491 ALG10B -0.51 -7.09 -0.4 1.22e-11 Morning vs. evening chronotype; CESC cis rs13095912 0.597 rs112800013 chr3:185313807 A/G cg11274856 chr3:185301563 NA 0.41 6.36 0.36 8.6e-10 Systolic blood pressure; CESC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1153858 0.621 rs12913645 chr15:45555066 G/A cg14582100 chr15:45693742 SPATA5L1 -0.41 -5.45 -0.32 1.16e-7 Homoarginine levels; CESC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg06808227 chr14:105710500 BRF1 -0.61 -6.98 -0.39 2.42e-11 Mean platelet volume;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13680954 chr1:1850738 TMEM52 -0.59 -7.05 -0.4 1.54e-11 Gut microbiome composition (summer); CESC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.6 -8.01 -0.44 3.74e-14 Total body bone mineral density; CESC cis rs7914558 1.000 rs7914558 chr10:104775908 G/A cg08650961 chr10:104748594 CNNM2 0.33 5.52 0.32 7.94e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs8062405 1.000 rs12446589 chr16:28870962 G/A cg08761264 chr16:28874980 SH2B1 -0.44 -5.37 -0.31 1.7e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9611565 0.649 rs202657 chr22:41844786 G/T cg17376030 chr22:41985996 PMM1 -0.77 -8.24 -0.45 8.27e-15 Vitiligo; CESC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg24578937 chr1:2090814 PRKCZ -0.32 -5.5 -0.32 9.1e-8 Height; CESC cis rs6748734 1.000 rs11898716 chr2:241828311 A/G cg04034577 chr2:241836375 C2orf54 -0.48 -7.98 -0.44 4.39e-14 Urinary metabolites; CESC cis rs7647973 0.626 rs4855846 chr3:49683526 G/A cg13072238 chr3:49761600 GMPPB -0.45 -5.46 -0.32 1.12e-7 Menarche (age at onset); CESC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.68 -0.33 3.49e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2204008 0.678 rs7299686 chr12:38212307 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.73 -0.33 2.66e-8 Bladder cancer; CESC cis rs10206020 0.885 rs11885392 chr2:1578182 C/A cg26248373 chr2:1572462 NA -0.61 -7.12 -0.4 9.87e-12 IgG glycosylation; CESC cis rs9303401 0.659 rs17222691 chr17:56771096 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.01 11.58 0.58 2.38e-25 Cognitive test performance; CESC cis rs7726839 0.574 rs12522955 chr5:639231 C/A cg16447950 chr5:562315 NA -0.58 -6.0 -0.35 6.45e-9 Obesity-related traits; CESC cis rs4566357 1.000 rs6705989 chr2:227923320 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -5.28 -0.31 2.76e-7 Coronary artery disease; CESC cis rs9486715 0.825 rs211158 chr6:97022938 C/G cg18709589 chr6:96969512 KIAA0776 -0.46 -6.62 -0.38 1.98e-10 Headache; CESC cis rs2274273 0.837 rs7148171 chr14:55770744 G/C cg04306507 chr14:55594613 LGALS3 0.31 6.09 0.35 4.01e-9 Protein biomarker; CESC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg12463550 chr7:65579703 CRCP -0.49 -6.42 -0.37 6.41e-10 Aortic root size; CESC cis rs7927771 1.000 rs34910028 chr11:47758449 T/C cg20307385 chr11:47447363 PSMC3 -0.52 -6.37 -0.36 8.3e-10 Subjective well-being; CESC cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg26116260 chr4:7069785 GRPEL1 0.99 14.54 0.67 1.24e-35 Monocyte percentage of white cells; CESC cis rs11785693 0.862 rs11781233 chr8:4993653 C/G cg26367366 chr8:4980734 NA -0.9 -8.97 -0.48 5.49e-17 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs9549260 0.755 rs2755216 chr13:41156938 G/A cg21288729 chr13:41239152 FOXO1 0.63 7.91 0.44 6.83e-14 Red blood cell count; CESC cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg21138405 chr5:131827807 IRF1 0.54 9.32 0.5 4.74e-18 Asthma (sex interaction); CESC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg02071572 chr4:1403502 NA 0.39 5.76 0.33 2.29e-8 Longevity; CESC cis rs6662572 1.000 rs72688469 chr1:46118393 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 5.65 0.33 4.18e-8 Blood protein levels; CESC cis rs644799 0.965 rs3016295 chr11:95554311 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 13.94 0.65 1.61e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs73206853 0.764 rs9737665 chr12:111031847 A/C cg12870014 chr12:110450643 ANKRD13A 0.64 5.7 0.33 3.22e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs3916 0.911 rs7313271 chr12:121152667 C/T cg21892295 chr12:121157589 UNC119B -0.36 -5.23 -0.31 3.47e-7 Urinary metabolites (H-NMR features); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19160353 chr10:3827878 KLF6 0.57 6.41 0.37 6.73e-10 Gut microbiome composition (summer); CESC cis rs2486288 0.656 rs7166580 chr15:45571209 C/G cg21132104 chr15:45694354 SPATA5L1 -0.57 -6.66 -0.38 1.55e-10 Glomerular filtration rate; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16703126 chr22:38598924 MAFF -0.48 -6.72 -0.38 1.08e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg24829409 chr8:58192753 C8orf71 0.67 7.92 0.44 6.49e-14 Developmental language disorder (linguistic errors); CESC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg08736216 chr1:53307985 ZYG11A 0.4 6.35 0.36 9.55e-10 Monocyte count; CESC cis rs501120 1.000 rs1746048 chr10:44775824 A/G cg09554077 chr10:44749378 NA -0.54 -7.09 -0.4 1.25e-11 Coronary artery disease;Coronary heart disease; CESC cis rs9308433 0.529 rs867444 chr1:214502160 T/C cg06198575 chr1:214491504 SMYD2 0.5 6.01 0.35 6.23e-9 IgG glycosylation; CESC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg01416388 chr22:39784598 NA -0.6 -7.51 -0.42 9.01e-13 Intelligence (multi-trait analysis); CESC cis rs2486288 0.656 rs11639420 chr15:45559268 A/C cg21132104 chr15:45694354 SPATA5L1 -0.56 -6.72 -0.38 1.09e-10 Glomerular filtration rate; CESC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg00684032 chr4:1343700 KIAA1530 0.56 8.59 0.47 7.56e-16 Obesity-related traits; CESC cis rs506597 0.704 rs4729598 chr7:100221867 T/C cg10426581 chr7:100472382 SRRT -0.69 -5.34 -0.31 2e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs10779751 0.770 rs2015818 chr1:11170743 G/A cg08854313 chr1:11322531 MTOR 0.79 11.29 0.57 2.1e-24 Body mass index; CESC cis rs116095464 0.558 rs6869925 chr5:264036 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.49 0.32 9.44e-8 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12391232 chr1:155247117 HCN3 0.61 6.6 0.38 2.27e-10 Gut microbiome composition (summer); CESC cis rs250677 0.687 rs185155 chr5:148455893 T/C cg18129178 chr5:148520854 ABLIM3 -0.52 -5.85 -0.34 1.45e-8 Breast cancer; CESC cis rs6973256 0.605 rs7808879 chr7:133345471 A/T cg10665199 chr7:133106180 EXOC4 0.46 6.19 0.36 2.31e-9 Intelligence (multi-trait analysis); CESC cis rs16867321 0.950 rs16867322 chr2:181369403 A/G cg23363182 chr2:181467187 NA -0.41 -5.13 -0.3 5.65e-7 Obesity; CESC cis rs2549003 1.000 rs3846732 chr5:131816087 T/C cg02551604 chr5:131831745 NA -0.37 -5.24 -0.31 3.21e-7 Asthma (sex interaction); CESC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg23601095 chr6:26197514 HIST1H3D -0.89 -8.25 -0.45 7.46e-15 Gout;Renal underexcretion gout; CESC cis rs7520050 0.966 rs6662641 chr1:46571509 T/A cg24296786 chr1:45957014 TESK2 0.41 5.17 0.3 4.63e-7 Red blood cell count;Reticulocyte count; CESC cis rs863345 0.967 rs2873588 chr1:158467615 T/A cg12129480 chr1:158549410 OR10X1 -0.32 -6.27 -0.36 1.42e-9 Pneumococcal bacteremia; CESC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg09658497 chr7:2847517 GNA12 -0.44 -5.87 -0.34 1.28e-8 Height; CESC trans rs11039798 0.544 rs114343057 chr11:48558172 C/T cg03929089 chr4:120376271 NA 0.62 6.07 0.35 4.44e-9 Axial length; CESC cis rs9916302 0.904 rs4794814 chr17:37696852 G/A cg20243544 chr17:37824526 PNMT 0.52 6.61 0.38 2.14e-10 Glomerular filtration rate (creatinine); CESC trans rs1557351 0.723 rs6566851 chr18:54723408 T/A cg11433624 chr6:7146702 RREB1 0.37 6.06 0.35 4.6e-9 Multiple sclerosis (age of onset); CESC cis rs1799949 0.965 rs7223952 chr17:41194885 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.48 6.55 0.37 3.03e-10 Menopause (age at onset); CESC cis rs6088580 0.634 rs6141465 chr20:32967314 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -6.97 -0.39 2.55e-11 Glomerular filtration rate (creatinine); CESC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg03264133 chr6:25882463 NA -0.51 -7.11 -0.4 1.05e-11 Intelligence (multi-trait analysis); CESC cis rs6582630 0.519 rs7294292 chr12:38349540 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.62e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs910316 1.000 rs175492 chr14:75545220 A/C cg16144293 chr14:75469539 EIF2B2 -0.38 -5.1 -0.3 6.44e-7 Height; CESC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg05368731 chr17:41323189 NBR1 0.8 10.6 0.55 4.09e-22 Menopause (age at onset); CESC cis rs1050631 0.592 rs1632169 chr18:33709762 G/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.52 7.04 0.4 1.63e-11 Esophageal squamous cell cancer (length of survival); CESC cis rs684232 0.563 rs12939528 chr17:524391 C/T cg15660573 chr17:549704 VPS53 -0.81 -11.99 -0.59 9.07e-27 Prostate cancer; CESC cis rs4654899 0.525 rs12035087 chr1:21471606 T/A cg05370193 chr1:21551575 ECE1 -0.38 -5.7 -0.33 3.13e-8 Superior frontal gyrus grey matter volume; CESC cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.68 -9.88 -0.52 8.36e-20 Hip circumference adjusted for BMI; CESC cis rs1538970 0.851 rs2055145 chr1:45926495 C/G cg05343316 chr1:45956843 TESK2 0.9 12.56 0.61 1.08e-28 Platelet count; CESC cis rs858239 0.508 rs2390754 chr7:23190494 A/G cg23682824 chr7:23144976 KLHL7 0.45 5.65 0.33 4.12e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg17372223 chr3:52568218 NT5DC2 -0.43 -6.2 -0.36 2.12e-9 Bipolar disorder; CESC cis rs11785400 0.731 rs4644221 chr8:143736984 C/T cg10596483 chr8:143751796 JRK -0.41 -5.33 -0.31 2.1e-7 Schizophrenia; CESC cis rs314370 0.951 rs12666989 chr7:100486754 G/C cg10426581 chr7:100472382 SRRT 0.85 8.23 0.45 8.68e-15 Resting heart rate; CESC cis rs12200560 0.505 rs11153095 chr6:97078592 T/C cg06623918 chr6:96969491 KIAA0776 -0.44 -5.63 -0.33 4.7e-8 Coronary heart disease; CESC cis rs4819143 0.504 rs6518259 chr21:47317886 C/G cg14185626 chr21:47401492 COL6A1 0.46 5.12 0.3 5.91e-7 Insulin resistance/response; CESC cis rs853679 0.599 rs149949 chr6:28011516 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.81 6.45 0.37 5.34e-10 Depression; CESC cis rs2439831 1.000 rs2467743 chr15:43750346 T/A cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.14 0.6 2.88e-27 Lung cancer in ever smokers; CESC cis rs6009527 1.000 rs6009188 chr22:49572751 G/A cg12746016 chr22:49560550 NA 0.34 5.33 0.31 2.09e-7 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); CESC cis rs1499972 0.648 rs62264767 chr3:117642005 A/C cg07612923 chr3:117604196 NA 0.66 5.98 0.34 7.1e-9 Schizophrenia; CESC cis rs478304 0.718 rs1151490 chr11:65390485 A/C cg27068330 chr11:65405492 SIPA1 0.46 5.47 0.32 1.03e-7 Acne (severe); CESC cis rs66573146 0.831 rs73088564 chr4:6984553 G/C cg00086871 chr4:6988644 TBC1D14 1.17 7.59 0.42 5.62e-13 Granulocyte percentage of myeloid white cells; CESC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.65e-39 Menopause (age at onset); CESC cis rs12142240 0.738 rs10489769 chr1:46806703 A/G cg00530320 chr1:46809349 NSUN4 0.59 7.87 0.44 9.26e-14 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26029250 chr17:40695519 NAGLU 0.5 6.79 0.38 7.48e-11 Fibrinogen levels; CESC cis rs13385 0.769 rs17286613 chr5:139581205 T/G cg26211634 chr5:139558579 C5orf32 0.49 5.47 0.32 1.02e-7 Atrial fibrillation; CESC cis rs10737909 0.510 rs12025158 chr1:15539259 A/G cg21012057 chr1:15538911 TMEM51 0.61 9.07 0.49 2.67e-17 Migraine; CESC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.93 -0.56 3.47e-23 Alzheimer's disease; CESC cis rs3749237 0.595 rs3870337 chr3:49557095 G/T cg07636037 chr3:49044803 WDR6 0.63 9.29 0.5 6.03e-18 Resting heart rate; CESC cis rs921968 0.565 rs11896209 chr2:219599268 C/T cg02176678 chr2:219576539 TTLL4 -0.44 -7.82 -0.43 1.23e-13 Mean corpuscular hemoglobin concentration; CESC cis rs3126085 0.800 rs55650366 chr1:152279920 A/G cg03465714 chr1:152285911 FLG 0.5 5.71 0.33 2.96e-8 Atopic dermatitis; CESC cis rs11828289 0.660 rs77575887 chr11:23174504 T/A cg20040320 chr11:23191996 NA -0.68 -5.88 -0.34 1.25e-8 Cancer; CESC cis rs2952156 1.000 rs2934971 chr17:37854507 G/T cg00129232 chr17:37814104 STARD3 -0.69 -8.96 -0.48 6.07e-17 Asthma; CESC cis rs2180341 0.889 rs9321074 chr6:127618019 G/A cg24812749 chr6:127587940 RNF146 1.06 15.35 0.69 1.74e-38 Breast cancer; CESC cis rs8038465 0.615 rs6495075 chr15:73981005 A/G cg15420318 chr15:73925796 NPTN 0.48 6.98 0.39 2.41e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1387259 0.931 rs11168474 chr12:48621384 A/C cg24011408 chr12:48396354 COL2A1 0.44 6.18 0.36 2.36e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs9549260 0.753 rs9532563 chr13:41160270 T/C cg21288729 chr13:41239152 FOXO1 0.53 5.22 0.31 3.57e-7 Red blood cell count; CESC cis rs12956009 0.583 rs11662486 chr18:44868325 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.45 0.37 5.28e-10 Educational attainment (years of education); CESC cis rs10489202 0.657 rs201540 chr1:167992883 G/A cg24449463 chr1:168025552 DCAF6 -0.4 -5.13 -0.3 5.62e-7 Schizophrenia; CESC cis rs863345 0.604 rs6699473 chr1:158495209 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.75e-11 Pneumococcal bacteremia; CESC cis rs1062177 1.000 rs2915877 chr5:151150601 C/G cg12924095 chr5:151150029 G3BP1 0.48 6.19 0.36 2.3e-9 Preschool internalizing problems; CESC cis rs7308134 0.766 rs79208794 chr12:1990170 C/G cg19708984 chr12:1973340 CACNA2D4 0.53 5.07 0.3 7.4e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs7772486 0.624 rs6930154 chr6:146025662 C/T cg05347473 chr6:146136440 FBXO30 -0.54 -7.06 -0.4 1.5e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9457247 1.000 rs422562 chr6:167406318 A/G cg23791538 chr6:167370224 RNASET2 -0.64 -9.16 -0.49 1.47e-17 Crohn's disease; CESC cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg06550200 chr5:1325588 CLPTM1L -0.67 -9.94 -0.52 5.33e-20 Lung cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18313694 chr15:45480185 SHF 0.47 6.05 0.35 4.8e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg27400923 chr3:185826929 ETV5 0.48 6.11 0.35 3.48e-9 Breast cancer;Type 2 diabetes; CESC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.52 -6.6 -0.38 2.18e-10 Tuberculosis; CESC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg16405210 chr4:1374714 KIAA1530 -0.91 -12.03 -0.59 6.78e-27 Longevity; CESC cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg19748678 chr4:122722346 EXOSC9 0.72 9.4 0.5 2.74e-18 Type 2 diabetes; CESC cis rs2249694 0.960 rs4351776 chr10:135415572 G/T cg19469447 chr10:135341870 CYP2E1 0.37 5.22 0.31 3.55e-7 Obesity-related traits; CESC cis rs4566357 0.615 rs2272204 chr2:227915601 G/T cg05526886 chr2:227700861 RHBDD1 -0.5 -6.54 -0.37 3.14e-10 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08974656 chr2:96931567 CIAO1;TMEM127 0.55 6.26 0.36 1.58e-9 Gut microbiome composition (summer); CESC cis rs735539 1.000 rs6490604 chr13:21284828 A/G cg04906043 chr13:21280425 IL17D -0.36 -5.15 -0.3 5.02e-7 Dental caries; CESC cis rs713587 0.967 rs6749422 chr2:25150011 C/G cg01884057 chr2:25150051 NA 0.42 7.78 0.43 1.6e-13 Body mass index in non-asthmatics; CESC cis rs12597458 0.789 rs7186207 chr16:72035359 C/T cg01557791 chr16:72042693 DHODH -0.83 -12.7 -0.62 3.56e-29 Prostate cancer; CESC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg08109568 chr15:31115862 NA 0.74 10.28 0.53 4.44e-21 Huntington's disease progression; CESC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg04315214 chr1:2043799 PRKCZ 0.64 10.88 0.56 5.03e-23 Height; CESC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.74 -10.18 -0.53 9.41e-21 Total body bone mineral density; CESC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg15445000 chr17:37608096 MED1 -0.4 -6.55 -0.37 3.05e-10 Glomerular filtration rate (creatinine); CESC cis rs938554 0.737 rs10939637 chr4:9977577 A/G cg00071950 chr4:10020882 SLC2A9 0.48 5.68 0.33 3.49e-8 Blood metabolite levels; CESC cis rs60843830 1.000 rs62114548 chr2:274672 C/G cg00108164 chr2:264199 ACP1;SH3YL1 0.8 10.3 0.53 3.86e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16620766 chr12:122268197 SETD1B 0.45 6.14 0.35 3.06e-9 Fibrinogen levels; CESC cis rs698833 0.828 rs6705951 chr2:44534012 A/C cg04920474 chr2:44395004 PPM1B 0.39 5.55 0.32 6.77e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs17666538 0.535 rs1669658 chr8:607380 A/G cg02524346 chr8:600233 NA 0.85 6.42 0.37 6.4e-10 IgG glycosylation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25713684 chr10:105127687 TAF5 0.47 6.3 0.36 1.22e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 10.34 0.54 2.91e-21 Platelet count; CESC cis rs599083 0.530 rs583545 chr11:68178635 T/C cg16797656 chr11:68205561 LRP5 -0.38 -5.09 -0.3 6.79e-7 Bone mineral density (spine); CESC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.43 -0.42 1.45e-12 Total body bone mineral density; CESC trans rs61931739 0.500 rs9669027 chr12:34583528 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.43 -0.42 1.46e-12 Morning vs. evening chronotype; CESC cis rs10426930 0.700 rs7246791 chr19:5013776 T/C cg18115693 chr19:4968519 KDM4B -0.42 -5.29 -0.31 2.62e-7 Monocyte percentage of white cells; CESC cis rs4523957 0.583 rs8068508 chr17:2047624 A/G cg16513277 chr17:2031491 SMG6 -0.77 -11.43 -0.57 7.26e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2380220 0.678 rs4308568 chr6:96009525 A/C cg15832292 chr6:96025679 MANEA -0.6 -6.51 -0.37 3.77e-10 Behavioural disinhibition (generation interaction); CESC cis rs727505 1.000 rs77718560 chr7:124514544 T/A cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs11122272 0.525 rs61835222 chr1:231537917 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -6.98 -0.39 2.38e-11 Hemoglobin concentration; CESC cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg19912559 chr1:40204330 PPIE 0.42 6.5 0.37 3.87e-10 Blood protein levels; CESC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg22800045 chr5:56110881 MAP3K1 0.83 10.29 0.53 4.05e-21 Initial pursuit acceleration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26251429 chr2:28113398 BRE;RBKS;LOC100302650 -0.44 -6.36 -0.36 8.64e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg25072359 chr17:41440525 NA 0.49 6.51 0.37 3.85e-10 Menopause (age at onset); CESC cis rs1050631 0.574 rs1789507 chr18:33732354 A/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.72e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg13298116 chr11:62369859 EML3;MTA2 0.64 9.31 0.5 5.15e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg25405998 chr7:65216604 CCT6P1 0.51 5.71 0.33 2.95e-8 Aortic root size; CESC cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg23711669 chr6:146136114 FBXO30 0.84 11.08 0.56 1.1e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.35 0.41 2.52e-12 Electroencephalogram traits; CESC cis rs3981351 0.528 rs12768908 chr10:115443894 C/T cg24846397 chr10:115438155 CASP7 -0.34 -5.27 -0.31 2.76e-7 Obesity-related traits; CESC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg08109568 chr15:31115862 NA -0.71 -9.5 -0.5 1.29e-18 Huntington's disease progression; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg17347471 chr5:52405518 MOCS2 -0.46 -6.32 -0.36 1.08e-9 Asthma; CESC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.6 0.33 5.33e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7208859 0.623 rs73267858 chr17:29059737 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1538970 1.000 rs4520450 chr1:45834773 A/G cg06784218 chr1:46089804 CCDC17 0.34 5.66 0.33 4e-8 Platelet count; CESC cis rs2243480 1.000 rs6460261 chr7:65215580 T/C cg18252515 chr7:66147081 NA 1.26 11.9 0.59 1.98e-26 Diabetic kidney disease; CESC trans rs921968 0.541 rs588770 chr2:219494638 T/C cg15547669 chr20:2781122 CPXM1 0.37 6.16 0.35 2.7e-9 Mean corpuscular hemoglobin concentration; CESC cis rs11122272 0.764 rs4486439 chr1:231477470 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -7.13 -0.4 9.56e-12 Hemoglobin concentration; CESC cis rs11077998 0.933 rs7215465 chr17:80532532 C/T cg10255544 chr17:80519551 FOXK2 0.55 8.73 0.47 2.83e-16 Reticulocyte fraction of red cells; CESC cis rs1707322 0.963 rs10789478 chr1:46350506 C/T cg03146154 chr1:46216737 IPP 0.78 10.67 0.55 2.45e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.34 -0.31 2e-7 Gut microbiome composition (summer); CESC cis rs3733585 0.699 rs7663097 chr4:9966791 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.58 -0.32 5.91e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3733585 0.699 rs6449172 chr4:9966036 A/T cg02734326 chr4:10020555 SLC2A9 -0.42 -5.87 -0.34 1.32e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7833986 0.501 rs2953910 chr8:56968761 C/G cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 6.89e-13 Height; CESC cis rs9926296 0.572 rs8047581 chr16:89884502 C/T cg04287289 chr16:89883240 FANCA 0.64 9.02 0.48 3.83e-17 Vitiligo; CESC cis rs1691799 0.899 rs1168325 chr12:66728234 C/G cg16791601 chr12:66731901 HELB -0.73 -12.46 -0.61 2.25e-28 White blood cell count (basophil); CESC cis rs4746818 0.892 rs10823298 chr10:70867083 T/C cg04149295 chr10:70884716 VPS26A 0.56 5.13 0.3 5.63e-7 Left atrial antero-posterior diameter; CESC trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.4 -0.46 2.71e-15 Intelligence (multi-trait analysis); CESC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.1 0.56 9.54e-24 Platelet count; CESC cis rs2243480 0.666 rs1880311 chr7:65276752 G/C cg18252515 chr7:66147081 NA 1.21 11.42 0.57 7.99e-25 Diabetic kidney disease; CESC cis rs644799 0.648 rs1016031 chr11:95473365 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.44 -5.89 -0.34 1.14e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11122272 0.735 rs2066140 chr1:231504311 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -7.37 -0.41 2.22e-12 Hemoglobin concentration; CESC cis rs9309473 0.583 rs6718864 chr2:73574591 A/G cg20560298 chr2:73613845 ALMS1 -0.46 -6.49 -0.37 4.21e-10 Metabolite levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02585102 chr12:49525240 TUBA1B -0.4 -6.06 -0.35 4.54e-9 Gambling; CESC cis rs5769707 0.609 rs2071890 chr22:50001291 G/A cg20744362 chr22:50050164 C22orf34 0.36 5.27 0.31 2.82e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs3820068 0.581 rs6693694 chr1:15980135 G/T cg13390004 chr1:15929781 NA 0.36 5.69 0.33 3.37e-8 Systolic blood pressure; CESC cis rs854765 0.655 rs4470201 chr17:17844870 G/A cg04398451 chr17:18023971 MYO15A -0.67 -9.61 -0.51 5.88e-19 Total body bone mineral density; CESC cis rs9611565 0.568 rs5751159 chr22:42175365 G/A cg06481639 chr22:41940642 POLR3H 0.47 5.28 0.31 2.75e-7 Vitiligo; CESC cis rs7845219 0.539 rs13271644 chr8:95853948 A/G cg09323728 chr8:95962352 TP53INP1 -0.26 -5.12 -0.3 5.82e-7 Type 2 diabetes; CESC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg15445000 chr17:37608096 MED1 0.4 6.37 0.36 8.09e-10 Urinary metabolites; CESC cis rs28489187 0.617 rs233109 chr1:85783101 T/C cg16011679 chr1:85725395 C1orf52 0.46 5.55 0.32 6.97e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs6964587 1.000 rs6968870 chr7:91661111 G/C cg17063962 chr7:91808500 NA 0.58 8.07 0.44 2.53e-14 Breast cancer; CESC cis rs9913156 0.696 rs72835620 chr17:4558128 G/A cg00122941 chr17:4613640 ARRB2 0.85 9.92 0.52 6.24e-20 Lymphocyte counts; CESC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg05234568 chr11:5960015 NA 0.65 8.67 0.47 4.54e-16 DNA methylation (variation); CESC cis rs9486715 0.830 rs4425602 chr6:96893906 G/A cg06623918 chr6:96969491 KIAA0776 0.92 14.36 0.66 5.75e-35 Headache; CESC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg05313129 chr8:58192883 C8orf71 -0.53 -6.16 -0.35 2.69e-9 Developmental language disorder (linguistic errors); CESC cis rs9911578 1.000 rs368186 chr17:56736659 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC cis rs3733585 0.699 rs6449157 chr4:9960442 G/A cg02734326 chr4:10020555 SLC2A9 -0.44 -6.11 -0.35 3.58e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg08027265 chr7:2291960 NA -0.47 -7.2 -0.4 6.11e-12 Bipolar disorder and schizophrenia; CESC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg12855166 chr17:30846586 MYO1D 0.4 5.05 0.3 8.34e-7 Schizophrenia; CESC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02753233 chr17:18218331 TOP3A;SMCR8 0.63 6.82 0.39 6.32e-11 Gut microbiome composition (summer); CESC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg10691866 chr7:65817282 TPST1 -0.32 -5.44 -0.32 1.19e-7 Aortic root size; CESC cis rs2797160 1.000 rs2747724 chr6:126004935 G/A cg05901451 chr6:126070800 HEY2 -0.45 -6.53 -0.37 3.43e-10 Endometrial cancer; CESC cis rs7586879 0.598 rs6545806 chr2:25124348 G/A cg01884057 chr2:25150051 NA 0.38 7.37 0.41 2.19e-12 Body mass index; CESC cis rs9858542 0.903 rs9875617 chr3:49634696 G/A cg07274523 chr3:49395745 GPX1 0.65 8.23 0.45 8.58e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs7173947 0.646 rs11634297 chr15:95267564 A/T cg05226323 chr17:71228757 FAM104A;C17orf80 -0.46 -6.11 -0.35 3.48e-9 Hematological and biochemical traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09163998 chr19:48103707 NA -0.63 -6.78 -0.38 7.85e-11 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.25 -0.31 3.16e-7 Lung cancer; CESC cis rs2243480 1.000 rs34136756 chr7:65381256 A/G cg25894440 chr7:65020034 NA -0.59 -5.07 -0.3 7.57e-7 Diabetic kidney disease; CESC cis rs10883723 0.810 rs7074343 chr10:104283165 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.59 0.42 5.46e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg09035930 chr12:129282057 SLC15A4 0.69 9.2 0.49 1.1e-17 Systemic lupus erythematosus; CESC cis rs2439831 0.867 rs28415933 chr15:43635800 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.73 0.55 1.57e-22 Lung cancer in ever smokers; CESC cis rs17253792 0.822 rs77033617 chr14:56129746 T/A cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02464656 chr6:44214659 HSP90AB1 -0.44 -6.09 -0.35 3.9e-9 Asthma; CESC cis rs11958404 0.932 rs60504573 chr5:157436786 T/A cg05962755 chr5:157440814 NA 0.59 6.43 0.37 5.93e-10 IgG glycosylation; CESC cis rs6982240 1.000 rs6982240 chr8:142257378 A/T cg00131261 chr8:142287264 NA -0.43 -6.47 -0.37 4.59e-10 Tonsillectomy; CESC cis rs2075371 0.863 rs1421479 chr7:133949345 T/G cg11752832 chr7:134001865 SLC35B4 0.52 6.77 0.38 8.12e-11 Mean platelet volume; CESC cis rs7267979 0.833 rs6138556 chr20:25243310 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.81 14.68 0.67 4.28e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs7927771 0.524 rs6485773 chr11:47763509 A/G cg20307385 chr11:47447363 PSMC3 0.61 8.6 0.47 7.26e-16 Subjective well-being; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26290114 chr13:52159332 WDFY2 0.47 6.32 0.36 1.11e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1003719 0.646 rs9985082 chr21:38501021 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.47 -0.46 1.69e-15 Eye color traits; CESC cis rs9399401 0.677 rs11155241 chr6:142664439 T/A cg04461802 chr6:142623433 GPR126 0.35 5.09 0.3 6.91e-7 Chronic obstructive pulmonary disease; CESC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg09658497 chr7:2847517 GNA12 -0.46 -7.03 -0.4 1.78e-11 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs2204008 0.811 rs11525004 chr12:38333807 T/A cg13010199 chr12:38710504 ALG10B 0.48 6.11 0.35 3.53e-9 Bladder cancer; CESC cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.853 rs4821811 chr22:39075145 C/T cg06544989 chr22:39130855 UNC84B 0.52 9.07 0.49 2.76e-17 Menopause (age at onset); CESC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg08888203 chr3:10149979 C3orf24 0.46 5.94 0.34 9.05e-9 Alzheimer's disease; CESC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg00310523 chr12:86230176 RASSF9 0.41 6.23 0.36 1.85e-9 Major depressive disorder; CESC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.75e-12 Tonsillectomy; CESC cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3733585 0.699 rs6449177 chr4:9968050 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.42 -0.32 1.32e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs929354 0.772 rs1182438 chr7:157027438 G/A cg05182265 chr7:156933206 UBE3C 0.48 7.11 0.4 1.05e-11 Body mass index; CESC cis rs6088580 0.634 rs6120666 chr20:33090718 A/G cg08999081 chr20:33150536 PIGU 0.66 11.69 0.58 9.97e-26 Glomerular filtration rate (creatinine); CESC cis rs4727027 0.933 rs6464940 chr7:148826309 G/T cg23583168 chr7:148888333 NA -0.74 -10.89 -0.56 4.6e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4076764 0.914 rs7536270 chr1:163377379 T/C cg06092702 chr1:163392909 NA -0.4 -5.94 -0.34 8.76e-9 Motion sickness; CESC trans rs35110281 0.714 rs7277539 chr21:45053011 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 6.85 0.39 5.05e-11 Mean corpuscular volume; CESC trans rs61931739 0.534 rs1586410 chr12:33999142 C/T cg26384229 chr12:38710491 ALG10B 0.58 8.06 0.44 2.57e-14 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19795592 chr19:40932176 SERTAD1 -0.65 -7.77 -0.43 1.7e-13 Gut microbiome composition (summer); CESC trans rs10242455 0.702 rs78218664 chr7:99154381 C/A cg09045935 chr12:6379348 NA 0.91 7.03 0.4 1.73e-11 Blood metabolite levels; CESC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg23978390 chr7:1156363 C7orf50 0.61 8.77 0.47 2.21e-16 Longevity;Endometriosis; CESC cis rs10887741 0.624 rs6586092 chr10:89428994 A/T cg13926569 chr10:89418898 PAPSS2 0.46 7.37 0.41 2.23e-12 Exercise (leisure time); CESC cis rs9911578 1.000 rs8076121 chr17:57041699 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.08 0.3 7.21e-7 Intelligence (multi-trait analysis); CESC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg20573242 chr4:122745356 CCNA2 0.62 7.64 0.42 3.94e-13 Type 2 diabetes; CESC cis rs6998277 0.830 rs7017839 chr8:103610769 G/C cg10187029 chr8:103597600 NA 0.74 9.55 0.51 9.29e-19 Migraine; CESC cis rs8062405 0.723 rs4788077 chr16:28569764 G/C cg07382826 chr16:28625726 SULT1A1 0.39 6.34 0.36 9.83e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6088590 1.000 rs2378256 chr20:33292127 G/C cg08999081 chr20:33150536 PIGU 0.59 8.82 0.48 1.54e-16 Coronary artery disease; CESC cis rs1559088 0.947 rs12461297 chr19:33559245 A/G cg27124370 chr19:33622961 WDR88 0.44 5.46 0.32 1.1e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9611565 0.649 rs5758344 chr22:41817685 G/A cg17376030 chr22:41985996 PMM1 -0.74 -7.8 -0.43 1.42e-13 Vitiligo; CESC cis rs782590 0.967 rs782592 chr2:55843875 T/A cg18811423 chr2:55921094 PNPT1 0.64 9.21 0.49 1.06e-17 Metabolic syndrome; CESC cis rs3892630 0.824 rs12327732 chr19:33221767 C/T cg22980127 chr19:33182716 NUDT19 1.03 11.32 0.57 1.67e-24 Red blood cell traits; CESC cis rs9549260 0.755 rs1923249 chr13:41143881 C/A cg21288729 chr13:41239152 FOXO1 0.66 8.4 0.46 2.69e-15 Red blood cell count; CESC cis rs12142240 0.738 rs41293275 chr1:46806429 A/T cg10495392 chr1:46806563 NSUN4 0.59 6.36 0.36 8.9e-10 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19418648 chr5:176789979 RGS14 -0.38 -6.4 -0.37 7.03e-10 Gambling; CESC cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg21138405 chr5:131827807 IRF1 0.54 9.32 0.5 4.74e-18 Asthma (sex interaction); CESC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg07092213 chr7:1199455 ZFAND2A -0.43 -5.81 -0.34 1.79e-8 Longevity;Endometriosis; CESC cis rs2929278 0.617 rs3087657 chr15:44063859 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.95 0.39 2.8e-11 Schizophrenia; CESC cis rs2425143 1.000 rs2425142 chr20:34350346 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.71 -0.43 2.53e-13 Blood protein levels; CESC cis rs2072732 0.861 rs12048975 chr1:2962225 T/C cg15211996 chr1:2936768 ACTRT2 0.34 5.44 0.32 1.19e-7 Plateletcrit; CESC cis rs941873 0.803 rs2105461 chr10:81101679 A/G cg11057378 chr10:81107060 PPIF -0.36 -5.86 -0.34 1.38e-8 Height; CESC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg12373951 chr3:133503437 NA 0.41 6.09 0.35 3.96e-9 Iron status biomarkers; CESC cis rs1975974 1.000 rs1985718 chr17:21731656 C/T cg18423549 chr17:21743878 NA -0.54 -7.26 -0.41 4.38e-12 Psoriasis; CESC cis rs9325144 0.555 rs6582607 chr12:38717678 T/C cg26384229 chr12:38710491 ALG10B -0.58 -7.99 -0.44 4.15e-14 Morning vs. evening chronotype; CESC cis rs936229 0.813 rs1378938 chr15:75096443 T/C cg14664628 chr15:75095509 CSK -0.93 -13.72 -0.64 9.83e-33 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg21770322 chr7:97807741 LMTK2 0.54 8.17 0.45 1.31e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs1153858 0.621 rs1706824 chr15:45579948 C/T cg14582100 chr15:45693742 SPATA5L1 0.4 5.29 0.31 2.52e-7 Homoarginine levels; CESC trans rs116095464 0.558 rs62347677 chr5:227453 A/G cg00938859 chr5:1591904 SDHAP3 0.61 6.7 0.38 1.23e-10 Breast cancer; CESC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg00750074 chr16:89608354 SPG7 -0.43 -6.23 -0.36 1.82e-9 Multiple myeloma (IgH translocation); CESC cis rs11098499 0.909 rs7659501 chr4:120371552 G/T cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs643506 0.845 rs7114594 chr11:111768113 A/G cg09085632 chr11:111637200 PPP2R1B 0.4 5.14 0.3 5.26e-7 Breast cancer; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg03461704 chr1:205818484 PM20D1 0.42 5.08 0.3 7.13e-7 Menarche (age at onset); CESC cis rs9640161 0.663 rs1916932 chr7:150021644 T/C cg21361702 chr7:150065534 REPIN1 0.46 5.42 0.32 1.37e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg26335602 chr6:28129616 ZNF389 0.53 6.86 0.39 4.94e-11 Depression; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg27326469 chr22:47133964 CERK -0.49 -6.56 -0.37 2.78e-10 Ulcerative colitis; CESC cis rs1881797 1.000 rs10925062 chr1:247658978 G/C cg18198730 chr1:247681584 NA 0.63 7.82 0.43 1.27e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs2645694 0.626 rs2645704 chr4:77830805 T/C cg18351406 chr4:77819688 ANKRD56 0.52 6.31 0.36 1.14e-9 Emphysema distribution in smoking; CESC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg02951883 chr7:2050386 MAD1L1 -0.56 -7.4 -0.41 1.75e-12 Bipolar disorder and schizophrenia; CESC cis rs7845219 0.544 rs6987400 chr8:95921295 T/C cg16049864 chr8:95962084 TP53INP1 -0.49 -7.22 -0.41 5.48e-12 Type 2 diabetes; CESC cis rs1008375 0.872 rs2315552 chr4:17627294 A/G cg04450456 chr4:17643702 FAM184B 0.38 5.47 0.32 1.05e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3096299 0.606 rs4785573 chr16:89565403 A/G cg08392591 chr16:89556376 ANKRD11 0.42 5.06 0.3 7.68e-7 Multiple myeloma (IgH translocation); CESC cis rs8141529 0.748 rs715531 chr22:29282679 A/G cg15103426 chr22:29168792 CCDC117 0.61 8.08 0.44 2.34e-14 Lymphocyte counts; CESC cis rs7301826 0.627 rs34103763 chr12:131290149 G/A cg11011512 chr12:131303247 STX2 -0.45 -5.46 -0.32 1.1e-7 Plasma plasminogen activator levels; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg01596986 chr13:48611463 NUDT15 -0.41 -6.26 -0.36 1.54e-9 Vertical cup-disc ratio; CESC cis rs5758659 0.653 rs133383 chr22:42473603 C/T cg04733989 chr22:42467013 NAGA 0.41 5.53 0.32 7.61e-8 Cognitive function; CESC cis rs17401966 0.898 rs11587495 chr1:10448999 T/C cg15208524 chr1:10270712 KIF1B 0.41 5.19 0.3 4.15e-7 Hepatocellular carcinoma; CESC cis rs11676348 0.846 rs6723449 chr2:218997580 C/T cg00012203 chr2:219082015 ARPC2 0.56 7.38 0.41 2e-12 Ulcerative colitis; CESC cis rs10089 1.000 rs2898096 chr5:127433214 C/T cg19767477 chr5:127420684 SLC12A2 -0.42 -5.7 -0.33 3.26e-8 Ileal carcinoids; CESC cis rs12681366 0.537 rs10956913 chr8:95483687 G/A cg13257157 chr8:95487014 RAD54B 0.46 5.64 0.33 4.39e-8 Nonsyndromic cleft lip with cleft palate; CESC cis rs815815 0.583 rs11125126 chr2:47395379 C/T cg27223769 chr2:47403360 CALM2 -0.44 -5.13 -0.3 5.48e-7 Dialysis-related mortality; CESC cis rs2637266 0.599 rs846574 chr10:78503082 G/A cg18941641 chr10:78392320 NA 0.42 7.82 0.43 1.26e-13 Pulmonary function; CESC cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.45 0.46 1.9e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.96 -11.59 -0.58 2.11e-25 Gut microbiome composition (summer); CESC cis rs6446731 0.614 rs6446727 chr4:3274488 T/A cg08886695 chr4:3369023 RGS12 -0.37 -5.44 -0.32 1.2e-7 Mean platelet volume; CESC cis rs9914988 0.778 rs35398767 chr17:27122960 A/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs7267979 1.000 rs4813563 chr20:25365340 T/C cg08601574 chr20:25228251 PYGB -0.38 -5.49 -0.32 9.43e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg22920501 chr2:26401640 FAM59B 0.66 8.25 0.45 7.35e-15 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs1622208 chr1:46498375 A/G cg06784218 chr1:46089804 CCDC17 -0.37 -6.36 -0.36 8.8e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3820068 0.603 rs35509554 chr1:15993514 C/T cg17385448 chr1:15911702 AGMAT 0.45 7.27 0.41 4.1e-12 Systolic blood pressure; CESC cis rs16854884 1.000 rs35887108 chr3:143780632 C/T cg06585982 chr3:143692056 C3orf58 0.46 5.05 0.3 8.3e-7 Economic and political preferences (feminism/equality); CESC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.1e-18 Prudent dietary pattern; CESC cis rs57502260 0.704 rs72936599 chr11:68320405 G/A cg20283391 chr11:68216788 NA -0.66 -5.47 -0.32 1.03e-7 Total body bone mineral density (age 45-60); CESC cis rs2933343 0.679 rs789221 chr3:128591625 A/G cg11901034 chr3:128598214 ACAD9 -0.36 -5.39 -0.31 1.55e-7 IgG glycosylation; CESC trans rs629535 0.590 rs56200825 chr8:70123450 G/A cg21567404 chr3:27674614 NA -0.85 -9.18 -0.49 1.31e-17 Dupuytren's disease; CESC cis rs12410462 0.581 rs75219436 chr1:227546617 C/T cg10327440 chr1:227177885 CDC42BPA -0.67 -5.69 -0.33 3.43e-8 Major depressive disorder; CESC cis rs911555 0.723 rs6575986 chr14:103886671 G/A cg12935359 chr14:103987150 CKB -0.56 -8.0 -0.44 3.82e-14 Intelligence (multi-trait analysis); CESC cis rs10911232 0.507 rs6672306 chr1:183058898 C/T ch.1.3577855R chr1:183094577 LAMC1 0.85 13.87 0.65 2.95e-33 Hypertriglyceridemia; CESC cis rs11997175 0.624 rs7819074 chr8:33682472 C/T ch.8.33884649F chr8:33765107 NA 0.57 7.29 0.41 3.65e-12 Body mass index; CESC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs7772486 0.790 rs4075694 chr6:146251108 G/C cg23711669 chr6:146136114 FBXO30 -0.94 -13.66 -0.64 1.66e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg16339924 chr4:17578868 LAP3 -0.68 -8.28 -0.45 6.19e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4664308 1.000 rs62175517 chr2:160911575 C/T cg03641300 chr2:160917029 PLA2R1 -0.68 -10.17 -0.53 9.82e-21 Idiopathic membranous nephropathy; CESC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg04369109 chr6:150039330 LATS1 -0.38 -5.04 -0.3 8.83e-7 Lung cancer; CESC cis rs13394619 0.775 rs10165819 chr2:11722102 A/T cg07314298 chr2:11723111 GREB1 -0.38 -5.3 -0.31 2.47e-7 Endometriosis; CESC cis rs9457247 0.637 rs9459846 chr6:167441023 T/G cg25258033 chr6:167368657 RNASET2 0.36 5.16 0.3 4.88e-7 Crohn's disease; CESC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.66 -0.33 3.97e-8 Total body bone mineral density; CESC cis rs7527798 0.592 rs11118337 chr1:207852693 G/C cg09232269 chr1:207846808 CR1L -0.28 -5.14 -0.3 5.27e-7 Erythrocyte sedimentation rate; CESC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg06481639 chr22:41940642 POLR3H -0.64 -6.61 -0.38 2.13e-10 Vitiligo; CESC cis rs2635047 0.530 rs4986228 chr18:44595259 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.14 0.3 5.46e-7 Educational attainment; CESC cis rs2839186 0.967 rs9637172 chr21:47685787 T/C cg10351095 chr21:47802916 PCNT -0.56 -7.65 -0.43 3.82e-13 Testicular germ cell tumor; CESC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg16325326 chr1:53192061 ZYG11B -0.69 -10.99 -0.56 2.09e-23 Monocyte count; CESC cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg15017067 chr4:17643749 FAM184B 0.39 5.6 0.33 5.4e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2295499 0.673 rs55641756 chr4:2704621 C/T cg27239842 chr4:2403781 ZFYVE28 -0.33 -5.6 -0.33 5.29e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs10733682 0.659 rs3861879 chr9:129464856 A/G cg00232160 chr9:129468157 NA 0.4 6.28 0.36 1.4e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01348570 chr4:68566604 UBA6;LOC550112 -0.42 -6.06 -0.35 4.74e-9 Gambling; CESC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.9 0.39 3.71e-11 Bipolar disorder; CESC cis rs7824557 0.606 rs2736270 chr8:11192593 G/A cg21775007 chr8:11205619 TDH 0.52 7.55 0.42 6.87e-13 Retinal vascular caliber; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01447966 chr1:234744778 IRF2BP2 0.6 6.95 0.39 2.82e-11 Gut microbiome composition (summer); CESC cis rs34779708 0.931 rs4934719 chr10:35376769 T/C cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg10691866 chr7:65817282 TPST1 -0.32 -5.44 -0.32 1.19e-7 Aortic root size; CESC cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.706 rs667239 chr17:37442241 A/G cg07936489 chr17:37558343 FBXL20 0.9 11.28 0.57 2.24e-24 Glomerular filtration rate (creatinine); CESC trans rs1814175 0.646 rs61904497 chr11:49883449 A/T cg03929089 chr4:120376271 NA -0.9 -14.51 -0.67 1.62e-35 Height; CESC cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg17366294 chr4:99064904 C4orf37 0.58 8.3 0.45 5.45e-15 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg18876405 chr7:65276391 NA 0.46 5.55 0.32 7.03e-8 Aortic root size; CESC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.87 0.34 1.33e-8 Tonsillectomy; CESC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg19163074 chr7:65112434 INTS4L2 -0.41 -5.11 -0.3 6.29e-7 Aortic root size; CESC cis rs734999 0.588 rs6668149 chr1:2558308 A/C cg18854424 chr1:2615690 NA -0.31 -5.91 -0.34 1.08e-8 Ulcerative colitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26462404 chr19:2270807 OAZ1 0.51 6.69 0.38 1.29e-10 Gut microbiota (bacterial taxa); CESC cis rs7937682 0.824 rs510866 chr11:111484113 A/C cg22437258 chr11:111473054 SIK2 0.72 9.71 0.51 2.86e-19 Primary sclerosing cholangitis; CESC cis rs2658782 0.951 rs2608215 chr11:93148817 G/A cg15737290 chr11:93063684 CCDC67 0.52 6.33 0.36 1.04e-9 Pulmonary function decline; CESC cis rs9790314 0.779 rs12493960 chr3:160899772 T/C cg03342759 chr3:160939853 NMD3 -0.41 -5.08 -0.3 7.1e-7 Morning vs. evening chronotype; CESC cis rs992157 0.835 rs2045434 chr2:219144498 A/G cg00012203 chr2:219082015 ARPC2 -0.76 -9.55 -0.51 9.45e-19 Colorectal cancer; CESC cis rs1062177 1.000 rs2964584 chr5:151142878 T/C cg00977110 chr5:151150581 G3BP1 0.66 7.15 0.4 8.34e-12 Preschool internalizing problems; CESC trans rs7819412 0.668 rs2409721 chr8:11038244 A/T cg15556689 chr8:8085844 FLJ10661 -0.54 -6.68 -0.38 1.41e-10 Triglycerides; CESC cis rs2506889 0.553 rs7548453 chr1:10589836 A/G cg17425144 chr1:10567563 PEX14 0.36 5.73 0.33 2.68e-8 Breast cancer; CESC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg06074448 chr4:187884817 NA -0.37 -5.45 -0.32 1.16e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs10754283 0.967 rs1934044 chr1:90107501 C/T cg21401794 chr1:90099060 LRRC8C -0.68 -9.16 -0.49 1.44e-17 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg19774624 chr17:42201019 HDAC5 -0.82 -12.61 -0.61 7.15e-29 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24641901 chr11:93212232 C11orf75 -0.58 -6.35 -0.36 9.34e-10 Gut microbiome composition (summer); CESC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21395147 chr1:211849137 NEK2 0.65 7.62 0.42 4.49e-13 Gut microbiome composition (summer); CESC cis rs7809799 0.850 rs6962075 chr7:98757940 A/G cg05967295 chr7:98741636 SMURF1 -0.75 -5.19 -0.3 4.14e-7 Ulcerative colitis; CESC cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg12386194 chr3:101231763 SENP7 0.46 5.68 0.33 3.57e-8 Colorectal cancer; CESC cis rs10911232 0.507 rs10797819 chr1:183006911 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.67 0.64 1.52e-32 Hypertriglyceridemia; CESC cis rs10779751 0.922 rs2746637 chr1:11275588 A/G cg08854313 chr1:11322531 MTOR 0.8 10.76 0.55 1.21e-22 Body mass index; CESC cis rs9325144 0.625 rs12227353 chr12:38734542 C/T cg26384229 chr12:38710491 ALG10B -0.56 -7.82 -0.43 1.27e-13 Morning vs. evening chronotype; CESC trans rs8073060 0.586 rs2523116 chr17:34025460 T/C cg19694781 chr19:47549865 TMEM160 -0.68 -6.25 -0.36 1.63e-9 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg17724175 chr1:150552817 MCL1 0.39 5.95 0.34 8.56e-9 Melanoma; CESC trans rs2727020 0.675 rs7929401 chr11:49350832 C/A cg03929089 chr4:120376271 NA -0.62 -6.72 -0.38 1.08e-10 Coronary artery disease; CESC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg27165867 chr14:105738592 BRF1 -0.51 -6.09 -0.35 3.89e-9 Mean platelet volume;Platelet distribution width; CESC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg27211696 chr2:191398769 TMEM194B 0.51 7.61 0.42 4.87e-13 Pulse pressure; CESC cis rs4975709 0.801 rs3797063 chr5:1881549 A/T cg17650747 chr5:1873721 NA 0.4 5.31 0.31 2.33e-7 Cardiovascular disease risk factors; CESC cis rs6582630 0.537 rs1851124 chr12:38516404 G/A cg26384229 chr12:38710491 ALG10B 0.73 11.35 0.57 1.32e-24 Drug-induced liver injury (flucloxacillin); CESC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.64 0.43 3.85e-13 Prudent dietary pattern; CESC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg07930192 chr7:1003750 NA 0.42 5.65 0.33 4.05e-8 Longevity;Endometriosis; CESC cis rs4268898 0.932 rs7577964 chr2:24598279 A/G cg20701182 chr2:24300061 SF3B14 -0.46 -5.48 -0.32 9.7e-8 Asthma; CESC cis rs2249625 0.874 rs2463733 chr6:72882996 T/C cg18830697 chr6:72922368 RIMS1 -0.39 -5.5 -0.32 8.88e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs2486288 0.656 rs11639349 chr15:45568260 C/T cg09092052 chr15:45571596 NA 0.51 5.92 0.34 9.94e-9 Glomerular filtration rate; CESC cis rs12478296 1.000 rs7420157 chr2:243005204 G/A cg06360820 chr2:242988706 NA -0.73 -9.03 -0.48 3.74e-17 Obesity-related traits; CESC cis rs6445967 0.530 rs12633937 chr3:58333637 C/T cg23715586 chr3:58305044 RPP14 -0.36 -5.08 -0.3 7.3e-7 Platelet count; CESC cis rs4474465 0.736 rs11237541 chr11:78261703 T/C cg27205649 chr11:78285834 NARS2 0.42 5.23 0.31 3.39e-7 Alzheimer's disease (survival time); CESC cis rs1005224 0.853 rs9323616 chr14:76151697 T/C cg25116370 chr14:76127843 TTLL5;C14orf1 -0.43 -5.88 -0.34 1.21e-8 Large artery stroke; CESC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg26752003 chr8:145688521 CYHR1 0.45 6.1 0.35 3.8e-9 Age at first birth; CESC cis rs7726839 0.540 rs72703087 chr5:598029 C/T cg16447950 chr5:562315 NA -0.6 -6.05 -0.35 4.91e-9 Obesity-related traits; CESC cis rs11696501 0.688 rs6065851 chr20:44279034 C/T cg11783356 chr20:44313418 WFDC10B -0.34 -5.19 -0.3 4.2e-7 Brain structure; CESC cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg17366294 chr4:99064904 C4orf37 0.56 7.55 0.42 6.87e-13 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 1.97e-8 Total body bone mineral density; CESC cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg00645731 chr22:42541494 CYP2D7P1 -0.34 -5.82 -0.34 1.7e-8 Cognitive function; CESC trans rs561341 0.941 rs4795664 chr17:30233467 C/T cg27661571 chr11:113659931 NA -0.65 -6.49 -0.37 4.23e-10 Hip circumference adjusted for BMI; CESC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.46e-17 Gut microbiome composition (summer); CESC cis rs4555082 0.834 rs2735826 chr14:105710866 G/A cg27165867 chr14:105738592 BRF1 -0.49 -5.3 -0.31 2.41e-7 Mean platelet volume;Platelet distribution width; CESC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg22800045 chr5:56110881 MAP3K1 0.73 9.21 0.49 1e-17 Initial pursuit acceleration; CESC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg08109568 chr15:31115862 NA -0.7 -9.34 -0.5 4.04e-18 Huntington's disease progression; CESC cis rs651907 0.557 rs34457525 chr3:101435225 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.88 0.34 1.22e-8 Colorectal cancer; CESC trans rs2727020 0.553 rs4980447 chr11:49591662 T/C cg15704280 chr7:45808275 SEPT13 -0.84 -10.3 -0.53 3.95e-21 Coronary artery disease; CESC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg09699651 chr6:150184138 LRP11 0.42 5.48 0.32 1.01e-7 Lung cancer; CESC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg19592336 chr6:28129416 ZNF389 0.61 8.24 0.45 8.13e-15 Depression; CESC cis rs1790761 0.658 rs684928 chr11:67329742 G/A cg00290607 chr11:67383545 NA 0.41 5.7 0.33 3.17e-8 Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09632163 chr16:2339292 ABCA3 0.45 6.13 0.35 3.14e-9 Fibrinogen levels; CESC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg04518342 chr5:131593106 PDLIM4 0.4 5.96 0.34 7.99e-9 Acylcarnitine levels; CESC cis rs2073300 0.609 rs6132615 chr20:23413200 T/C cg16736954 chr20:23401023 NAPB 0.78 5.68 0.33 3.45e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6432018 0.964 rs13415136 chr2:9729708 A/G cg23886495 chr2:9695866 ADAM17 0.44 5.14 0.3 5.32e-7 Heart rate variability traits; CESC cis rs7680126 0.633 rs74469609 chr4:10294424 G/A cg11266682 chr4:10021025 SLC2A9 -0.43 -5.58 -0.32 5.89e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs7264396 0.635 rs6060685 chr20:34512023 G/A cg17201900 chr20:34330562 RBM39 0.49 5.13 0.3 5.54e-7 Total cholesterol levels; CESC cis rs8114671 0.527 rs2253484 chr20:33405263 A/T cg06115741 chr20:33292138 TP53INP2 -0.45 -5.35 -0.31 1.87e-7 Height; CESC cis rs3820928 0.692 rs2396434 chr2:227775223 G/T cg05526886 chr2:227700861 RHBDD1 -0.54 -7.32 -0.41 3e-12 Pulmonary function; CESC cis rs6582630 0.519 rs11182457 chr12:38538331 G/A cg26384229 chr12:38710491 ALG10B 0.74 11.17 0.57 5.31e-24 Drug-induced liver injury (flucloxacillin); CESC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs997295 0.529 rs12592315 chr15:68040266 A/G cg05642446 chr12:117316716 HRK 0.47 6.34 0.36 9.82e-10 Motion sickness; CESC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg03806693 chr22:41940476 POLR3H -1.19 -15.09 -0.68 1.46e-37 Vitiligo; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg17447877 chr11:65554407 OVOL1 -0.46 -6.04 -0.35 5.19e-9 Height; CESC cis rs921968 0.643 rs545779 chr2:219336108 A/G cg02176678 chr2:219576539 TTLL4 0.43 7.65 0.43 3.63e-13 Mean corpuscular hemoglobin concentration; CESC cis rs9911578 1.000 rs302848 chr17:56686454 C/T cg05425664 chr17:57184151 TRIM37 -0.53 -7.42 -0.41 1.58e-12 Intelligence (multi-trait analysis); CESC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12220238 0.558 rs76330316 chr10:76002291 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.08 0.35 4.12e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs73058052 1.000 rs12462756 chr19:50098423 G/A cg09250473 chr19:50168907 IRF3;BCL2L12 0.59 5.65 0.33 4.22e-8 Fibrinogen levels; CESC cis rs6541297 0.703 rs619899 chr1:230310069 A/G cg20703242 chr1:230279135 GALNT2 -0.43 -5.59 -0.33 5.51e-8 Coronary artery disease; CESC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg19729930 chr2:74357872 NA 0.86 13.07 0.63 1.83e-30 Gestational age at birth (maternal effect); CESC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg10691866 chr7:65817282 TPST1 -0.32 -5.45 -0.32 1.15e-7 Aortic root size; CESC cis rs2228479 0.867 rs73276534 chr16:89950557 A/G cg00800038 chr16:89945340 TCF25 -0.64 -7.05 -0.4 1.52e-11 Skin colour saturation; CESC cis rs3015497 1.000 rs3015497 chr14:51113398 T/C cg26011998 chr14:51135199 SAV1 -0.41 -5.2 -0.3 3.97e-7 Mean platelet volume; CESC cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg05283184 chr6:79620031 NA -0.45 -6.87 -0.39 4.53e-11 Intelligence (multi-trait analysis); CESC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg04282206 chr17:62833786 PLEKHM1P 0.56 6.48 0.37 4.45e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs13082711 0.522 rs569960 chr3:27329540 C/T cg02860705 chr3:27208620 NA 0.4 5.43 0.32 1.27e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.52 7.26 0.41 4.33e-12 Menopause (age at onset); CESC cis rs9733 0.715 rs12402006 chr1:150869829 G/A cg22823121 chr1:150693482 HORMAD1 -0.36 -5.17 -0.3 4.66e-7 Tonsillectomy; CESC cis rs4242434 0.927 rs2291234 chr8:22464390 T/C cg03733263 chr8:22462867 KIAA1967 0.95 16.01 0.7 7.75e-41 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs11098499 0.657 rs7664458 chr4:120371967 A/G cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs4588572 0.643 rs7701154 chr5:77716621 G/A cg11547950 chr5:77652471 NA -0.44 -5.61 -0.33 5.15e-8 Triglycerides; CESC cis rs2710642 0.861 rs2710644 chr2:63248968 A/C cg17519650 chr2:63277830 OTX1 0.61 7.33 0.41 2.73e-12 LDL cholesterol levels;LDL cholesterol; CESC cis rs4803468 1.000 rs10417997 chr19:41902361 G/A cg09537434 chr19:41945824 ATP5SL -1.01 -17.92 -0.74 1.36e-47 Height; CESC cis rs17401966 1.000 rs60743860 chr1:10442926 G/C cg15208524 chr1:10270712 KIF1B 0.46 5.84 0.34 1.52e-8 Hepatocellular carcinoma; CESC cis rs1559088 0.901 rs7249983 chr19:33598851 C/A cg27124370 chr19:33622961 WDR88 0.46 6.08 0.35 4.11e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg25427524 chr10:38739819 LOC399744 -0.69 -10.3 -0.53 3.72e-21 Extrinsic epigenetic age acceleration; CESC cis rs7937682 0.889 rs559482 chr11:111497902 G/A cg09085632 chr11:111637200 PPP2R1B -1.0 -15.55 -0.69 3.45e-39 Primary sclerosing cholangitis; CESC cis rs8027181 0.839 rs9460 chr15:73044575 C/T cg25632853 chr15:73088954 NA 0.31 5.51 0.32 8.53e-8 Triglyceride levels; CESC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg13206674 chr6:150067644 NUP43 0.46 6.49 0.37 4.15e-10 Lung cancer; CESC cis rs4654899 0.865 rs6671056 chr1:21488610 G/A cg05370193 chr1:21551575 ECE1 0.46 7.08 0.4 1.28e-11 Superior frontal gyrus grey matter volume; CESC cis rs7216064 1.000 rs12602912 chr17:65870073 C/T cg07042672 chr17:66097459 LOC651250 -0.54 -5.59 -0.32 5.61e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs17433780 0.964 rs12146148 chr1:89471892 C/T cg09516651 chr1:89888402 LOC400759 0.67 9.03 0.49 3.54e-17 Carotid intima media thickness; CESC cis rs523522 0.962 rs12814055 chr12:120987391 G/A cg27279351 chr12:120934652 DYNLL1 0.68 8.94 0.48 6.97e-17 High light scatter reticulocyte count; CESC cis rs6088580 0.524 rs6088552 chr20:33226491 A/G cg24642439 chr20:33292090 TP53INP2 -0.47 -5.39 -0.31 1.57e-7 Glomerular filtration rate (creatinine); CESC cis rs11608355 0.545 rs12819142 chr12:109896316 G/T cg05360138 chr12:110035743 NA 0.79 8.25 0.45 7.43e-15 Neuroticism; CESC cis rs9457247 1.000 rs364451 chr6:167384756 G/A cg07741184 chr6:167504864 NA 0.3 5.52 0.32 7.99e-8 Crohn's disease; CESC cis rs2635047 0.601 rs2576057 chr18:44644127 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.56 0.32 6.6e-8 Educational attainment; CESC cis rs17001868 0.568 rs9611328 chr22:40791972 C/T cg07138101 chr22:40742427 ADSL 0.56 5.36 0.31 1.81e-7 Mammographic density (dense area); CESC trans rs208520 1.000 rs12212063 chr6:66985148 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 8.47 0.46 1.71e-15 Exhaled nitric oxide output; CESC cis rs79349575 0.687 rs12602179 chr17:47010034 G/T cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC trans rs801193 0.613 rs2016325 chr7:66323500 T/C cg26939375 chr7:64535504 NA -0.52 -6.31 -0.36 1.14e-9 Aortic root size; CESC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg21770322 chr7:97807741 LMTK2 0.55 8.18 0.45 1.16e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.94 13.81 0.65 4.88e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs599083 0.590 rs661988 chr11:68189251 T/G cg01657329 chr11:68192670 LRP5 -0.5 -5.06 -0.3 7.75e-7 Bone mineral density (spine); CESC cis rs739401 1.000 rs739401 chr11:3036324 C/T cg08508325 chr11:3079039 CARS 0.43 7.92 0.44 6.69e-14 Longevity; CESC cis rs7267979 1.000 rs1888998 chr20:25291826 A/G cg08601574 chr20:25228251 PYGB -0.36 -5.13 -0.3 5.74e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2070488 0.775 rs6599207 chr3:38554901 T/C cg24069376 chr3:38537580 EXOG -0.34 -5.92 -0.34 1e-8 Electrocardiographic conduction measures; CESC cis rs77972916 0.505 rs3851318 chr2:43532808 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.61 -5.97 -0.34 7.4e-9 Granulocyte percentage of myeloid white cells; CESC cis rs1035144 0.524 rs8009260 chr14:81408591 G/T cg06600135 chr14:81408086 NA 0.51 6.8 0.39 6.73e-11 Male sexual orientation; CESC cis rs561341 1.000 rs510264 chr17:30323414 A/G cg19193384 chr17:30244184 NA -0.71 -6.61 -0.38 2.14e-10 Hip circumference adjusted for BMI; CESC cis rs9911578 0.967 rs2643124 chr17:56741672 T/C cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.66e-39 Intelligence (multi-trait analysis); CESC trans rs804280 0.509 rs9886639 chr8:11784529 G/T cg15556689 chr8:8085844 FLJ10661 0.53 6.43 0.37 5.88e-10 Myopia (pathological); CESC cis rs10851478 0.872 rs12912703 chr15:49869141 C/G cg08060515 chr15:49448048 GALK2;COPS2 0.43 5.25 0.31 3.07e-7 Oral cavity cancer; CESC cis rs2839186 0.786 rs7409792 chr21:47691729 C/A cg10351095 chr21:47802916 PCNT -0.51 -6.94 -0.39 3e-11 Testicular germ cell tumor; CESC cis rs4481887 0.893 rs4423045 chr1:248479495 T/C cg00666640 chr1:248458726 OR2T12 0.33 5.45 0.32 1.17e-7 Common traits (Other); CESC cis rs11126435 0.591 rs6546909 chr2:74746322 A/T cg11955373 chr2:74710513 TTC31;CCDC142 0.51 5.14 0.3 5.35e-7 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg17430032 chr12:64317120 SRGAP1 0.47 6.95 0.39 2.84e-11 Thyroid stimulating hormone; CESC cis rs2294693 0.853 rs9296350 chr6:40977623 G/A cg14418226 chr6:40996092 UNC5CL 0.47 5.87 0.34 1.27e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs933688 1.000 rs35712350 chr5:90679519 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.19 17.21 0.73 4.47e-45 Smoking behavior; CESC cis rs9815354 0.767 rs11917248 chr3:41885723 T/C cg03022575 chr3:42003672 ULK4 0.45 5.29 0.31 2.59e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs12410462 0.681 rs114950580 chr1:227673334 G/C cg04117972 chr1:227635322 NA 0.82 6.26 0.36 1.51e-9 Major depressive disorder; CESC trans rs722599 0.683 rs7160852 chr14:75239424 T/C cg00095594 chr1:236228625 NID1 0.4 6.14 0.35 3e-9 IgG glycosylation; CESC cis rs12142240 0.698 rs112068407 chr1:46822291 T/C cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs6120849 0.901 rs6088739 chr20:33748724 G/A cg24642439 chr20:33292090 TP53INP2 0.61 6.53 0.37 3.26e-10 Protein C levels; CESC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg27170947 chr2:26402098 FAM59B 0.87 10.16 0.53 1.05e-20 Gut microbiome composition (summer); CESC cis rs4568518 0.530 rs10269921 chr7:17997940 G/A cg03009463 chr7:17980271 SNX13 0.44 5.77 0.33 2.18e-8 Measles; CESC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.97 9.35 0.5 3.75e-18 Platelet count; CESC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg23708337 chr7:1209742 NA 0.54 5.38 0.31 1.61e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg23161317 chr6:28129485 ZNF389 0.51 6.63 0.38 1.85e-10 Depression; CESC cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg18230493 chr5:56204884 C5orf35 -0.66 -8.38 -0.46 3.04e-15 Initial pursuit acceleration; CESC trans rs9650657 0.513 rs7005884 chr8:10796472 A/G cg15556689 chr8:8085844 FLJ10661 -0.56 -6.85 -0.39 5.05e-11 Neuroticism; CESC cis rs7165102 1.000 rs7165102 chr15:65888359 G/T cg11441148 chr15:65824328 PTPLAD1 0.32 5.43 0.32 1.29e-7 Mean corpuscular hemoglobin; CESC cis rs10089 0.951 rs56066100 chr5:127460571 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.07 0.53 2.04e-20 Ileal carcinoids; CESC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg27125505 chr17:43679177 LOC644172 -0.48 -6.74 -0.38 1.01e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9399401 0.710 rs12190271 chr6:142681409 A/G cg04461802 chr6:142623433 GPR126 -0.39 -5.76 -0.33 2.38e-8 Chronic obstructive pulmonary disease; CESC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg18099408 chr3:52552593 STAB1 -0.3 -5.05 -0.3 8.2e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21918026 chr16:68344902 SLC7A6OS;PRMT7 -0.6 -6.34 -0.36 9.81e-10 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg14440974 chr22:39074834 NA -0.43 -5.76 -0.33 2.3e-8 Menopause (age at onset); CESC cis rs6088580 0.660 rs6087592 chr20:33114503 A/G cg08999081 chr20:33150536 PIGU 0.64 11.0 0.56 1.94e-23 Glomerular filtration rate (creatinine); CESC cis rs3096299 0.967 rs753852 chr16:89446419 G/A cg08392591 chr16:89556376 ANKRD11 0.42 5.31 0.31 2.34e-7 Multiple myeloma (IgH translocation); CESC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg03351412 chr1:154909251 PMVK 0.68 9.09 0.49 2.38e-17 Prostate cancer; CESC cis rs7851660 0.874 rs7037175 chr9:100631662 G/C cg13688889 chr9:100608707 NA -0.6 -8.55 -0.47 9.84e-16 Strep throat; CESC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg23161317 chr6:28129485 ZNF389 0.46 6.18 0.35 2.4e-9 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00661620 chr1:93298059 RPL5 0.59 6.53 0.37 3.25e-10 Gut microbiome composition (summer); CESC trans rs896655 0.567 rs10811625 chr9:21826840 G/A cg04880063 chr10:102790718 SFXN3;PDZD7 0.41 6.0 0.35 6.34e-9 Coronary artery disease; CESC cis rs7927771 0.931 rs4752801 chr11:47907641 A/G cg20307385 chr11:47447363 PSMC3 -0.44 -5.55 -0.32 6.93e-8 Subjective well-being; CESC cis rs8051149 0.688 rs16943320 chr16:87870379 A/G cg03408354 chr16:87871219 SLC7A5 -0.45 -5.68 -0.33 3.61e-8 Blood metabolite levels; CESC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.37 0.41 2.17e-12 Bipolar disorder; CESC cis rs2439831 0.717 rs2470132 chr15:43835481 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 8.9 0.48 8.94e-17 Lung cancer in ever smokers; CESC trans rs1814175 0.619 rs847644 chr11:49918418 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs9905704 0.718 rs62083411 chr17:56980188 A/G cg12560992 chr17:57184187 TRIM37 0.63 5.53 0.32 7.65e-8 Testicular germ cell tumor; CESC cis rs798554 0.679 rs798499 chr7:2792013 G/A cg13628971 chr7:2884303 GNA12 0.39 5.12 0.3 5.76e-7 Height; CESC cis rs7264396 0.790 rs6060562 chr20:34282053 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -10.37 -0.54 2.22e-21 Total cholesterol levels; CESC cis rs9943753 0.508 rs11066422 chr12:109807153 A/G cg19025524 chr12:109796872 NA -0.47 -6.7 -0.38 1.23e-10 HDL cholesterol; CESC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg23743428 chr13:21893420 NA -0.38 -6.1 -0.35 3.69e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1348850 0.608 rs2364845 chr2:178226240 T/C cg23306229 chr2:178417860 TTC30B 0.54 6.91 0.39 3.51e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs116095464 0.558 rs10057492 chr5:239503 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.31 0.31 2.3e-7 Breast cancer; CESC cis rs4481887 0.888 rs12042602 chr1:248482053 C/T cg00666640 chr1:248458726 OR2T12 0.36 6.07 0.35 4.47e-9 Common traits (Other); CESC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.59 7.12 0.4 1.01e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4423214 0.650 rs7940244 chr11:71221574 C/T cg24826892 chr11:71159390 DHCR7 -0.52 -5.84 -0.34 1.54e-8 Vitamin D levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01630199 chr7:66369076 NA 0.53 7.06 0.4 1.45e-11 Fibrinogen levels; CESC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg19046167 chr17:80928561 B3GNTL1 0.47 5.61 0.33 5.16e-8 Glycated hemoglobin levels; CESC cis rs66573146 0.572 rs55740475 chr4:6954092 C/G cg26116260 chr4:7069785 GRPEL1 -0.8 -5.31 -0.31 2.3e-7 Granulocyte percentage of myeloid white cells; CESC cis rs11677416 0.601 rs12469600 chr2:113572357 T/C cg27083787 chr2:113543245 IL1A 0.59 7.01 0.4 2e-11 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs10950821 0.505 rs6949755 chr7:20688042 C/G cg02470904 chr7:20686108 ABCB5 0.33 5.44 0.32 1.22e-7 Response to statin therapy; CESC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.85 12.01 0.59 8.38e-27 Age-related macular degeneration (geographic atrophy); CESC cis rs7927592 0.731 rs11228275 chr11:68303980 G/A cg16797656 chr11:68205561 LRP5 -0.49 -7.79 -0.43 1.56e-13 Total body bone mineral density; CESC cis rs11031096 0.678 rs61899666 chr11:4178711 C/A cg18678763 chr11:4115507 RRM1 -0.42 -5.75 -0.33 2.5e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7927592 0.956 rs11228269 chr11:68289796 A/G cg20283391 chr11:68216788 NA -0.49 -5.84 -0.34 1.56e-8 Total body bone mineral density; CESC cis rs116095464 0.614 rs10067482 chr5:219328 T/G cg22496380 chr5:211416 CCDC127 -0.72 -8.57 -0.47 8.59e-16 Breast cancer; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg17372223 chr3:52568218 NT5DC2 0.55 9.32 0.5 4.7e-18 Electroencephalogram traits; CESC cis rs9314323 0.964 rs3808576 chr8:26266834 G/A cg13160058 chr8:26243215 BNIP3L -0.32 -5.16 -0.3 4.9e-7 Red cell distribution width; CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg26354017 chr1:205819088 PM20D1 -0.71 -11.51 -0.58 3.87e-25 Monocyte percentage of white cells; CESC cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg05340658 chr4:99064831 C4orf37 0.75 11.02 0.56 1.71e-23 Colonoscopy-negative controls vs population controls; CESC cis rs910316 1.000 rs3742780 chr14:75505008 G/C cg11812906 chr14:75593930 NEK9 0.88 14.5 0.67 1.74e-35 Height; CESC cis rs7843479 0.582 rs13439690 chr8:21778082 T/C cg17168535 chr8:21777572 XPO7 0.74 12.06 0.6 5.5e-27 Mean corpuscular volume; CESC cis rs13256369 0.755 rs11776987 chr8:8559401 C/G cg00074818 chr8:8560427 CLDN23 0.38 5.37 0.31 1.71e-7 Obesity-related traits; CESC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg22823121 chr1:150693482 HORMAD1 0.47 7.03 0.4 1.79e-11 Tonsillectomy; CESC cis rs17125944 0.686 rs4450307 chr14:53334783 G/A cg00686598 chr14:53173677 PSMC6 -0.63 -5.26 -0.31 2.99e-7 Alzheimer's disease (late onset); CESC cis rs34779708 0.733 rs3853672 chr10:35549606 A/C cg04310649 chr10:35416472 CREM -0.46 -5.25 -0.31 3.17e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg24846343 chr22:24311635 DDTL 0.64 10.82 0.55 7.67e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4727027 0.933 rs1058059 chr7:148879134 A/T cg23158103 chr7:148848205 ZNF398 -0.4 -6.45 -0.37 5.26e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25318278 chr11:50257830 LOC441601 -0.57 -7.68 -0.43 3.11e-13 Gut microbiome composition (summer); CESC cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg25174290 chr11:3078921 CARS -0.56 -7.98 -0.44 4.51e-14 Longevity; CESC cis rs9549367 0.789 rs34448227 chr13:113884754 A/C cg18105134 chr13:113819100 PROZ -0.63 -7.52 -0.42 8.31e-13 Platelet distribution width; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg06632829 chr19:45394476 TOMM40 -0.55 -7.63 -0.42 4.22e-13 Height; CESC cis rs4450131 0.522 rs17152232 chr10:126398927 A/G cg20435097 chr10:126320824 FAM53B 0.28 5.13 0.3 5.62e-7 White blood cell count (basophil); CESC cis rs7824557 0.527 rs2409756 chr8:11242025 A/C cg21775007 chr8:11205619 TDH -0.54 -7.27 -0.41 4.17e-12 Retinal vascular caliber; CESC cis rs4234284 0.556 rs9968173 chr3:126965437 G/A cg27326032 chr3:127006922 NA -0.41 -5.62 -0.33 4.83e-8 Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel); CESC cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg00745463 chr17:30367425 LRRC37B -0.78 -7.09 -0.4 1.2e-11 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13633529 chr15:101141955 ASB7;LINS1 -0.54 -6.34 -0.36 1.01e-9 Gut microbiome composition (summer); CESC cis rs12618769 0.597 rs11888595 chr2:99084708 T/G cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs644799 1.000 rs494829 chr11:95571750 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.94 13.73 0.64 9.26e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1371867 0.839 rs1660313 chr8:101332712 G/A cg11906718 chr8:101322791 RNF19A 0.53 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26011156 chr1:156183096 PMF1 -0.45 -6.41 -0.37 6.64e-10 Gambling; CESC cis rs914615 0.552 rs11264337 chr1:155138450 C/T cg02153340 chr1:155202674 NA -0.37 -5.48 -0.32 1.01e-7 Urinary albumin-to-creatinine ratio; CESC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg07701084 chr6:150067640 NUP43 0.44 5.95 0.34 8.59e-9 Lung cancer; CESC cis rs27434 0.583 rs151908 chr5:96156494 A/G cg16492584 chr5:96139282 ERAP1 -0.36 -5.09 -0.3 6.81e-7 Ankylosing spondylitis; CESC trans rs2351088 0.706 rs11704989 chr22:46205231 A/G cg07046818 chr8:97166291 GDF6 -0.48 -6.06 -0.35 4.68e-9 Tonsillectomy; CESC cis rs11031096 0.678 rs2044135 chr11:4187233 G/A cg18678763 chr11:4115507 RRM1 -0.47 -6.31 -0.36 1.19e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs17001868 0.614 rs61467436 chr22:40736713 T/C cg07138101 chr22:40742427 ADSL 0.57 5.38 0.31 1.66e-7 Mammographic density (dense area); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02068989 chr1:10458939 PGD -0.54 -6.72 -0.38 1.09e-10 Ulcerative colitis; CESC cis rs9611565 0.921 rs5751077 chr22:41720728 G/C cg06481639 chr22:41940642 POLR3H -0.45 -5.36 -0.31 1.83e-7 Vitiligo; CESC trans rs13398848 1.000 rs10192434 chr2:84201256 C/T cg23262351 chr6:79576851 IRAK1BP1 -0.69 -6.08 -0.35 4.1e-9 Conduct disorder (symptom count);Conduct disorder; CESC cis rs832540 1.000 rs192249 chr5:56197514 C/G cg14703610 chr5:56206110 C5orf35 0.53 7.03 0.4 1.73e-11 Coronary artery disease; CESC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg02951883 chr7:2050386 MAD1L1 -0.53 -7.02 -0.4 1.91e-11 Bipolar disorder and schizophrenia; CESC cis rs1878931 0.501 rs9302871 chr16:3415512 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.77 10.22 0.53 6.84e-21 Body mass index (adult); CESC cis rs8077889 0.703 rs231532 chr17:41945769 C/T cg26893861 chr17:41843967 DUSP3 -0.65 -6.7 -0.38 1.28e-10 Triglycerides; CESC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC trans rs2898290 0.622 rs978803 chr8:11343475 C/T cg15556689 chr8:8085844 FLJ10661 0.5 6.02 0.35 5.89e-9 Systolic blood pressure; CESC cis rs6831352 0.918 rs4699712 chr4:100060490 A/T cg12011299 chr4:100065546 ADH4 -0.59 -6.59 -0.38 2.35e-10 Alcohol dependence; CESC trans rs9467711 0.606 rs2076030 chr6:26426856 G/A cg06606381 chr12:133084897 FBRSL1 -0.82 -6.98 -0.39 2.4e-11 Autism spectrum disorder or schizophrenia; CESC cis rs4568518 0.501 rs6966247 chr7:17989247 A/G cg03009463 chr7:17980271 SNX13 0.4 5.27 0.31 2.79e-7 Measles; CESC cis rs6580649 0.941 rs1793933 chr12:48396450 G/T cg05342945 chr12:48394962 COL2A1 -0.54 -6.44 -0.37 5.55e-10 Lung cancer; CESC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg22823121 chr1:150693482 HORMAD1 0.42 5.86 0.34 1.35e-8 Melanoma; CESC cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg20573242 chr4:122745356 CCNA2 0.76 10.31 0.54 3.5e-21 Type 2 diabetes; CESC trans rs7142881 0.508 rs1954441 chr14:32118713 A/G cg07757386 chr14:102771445 RAGE -0.46 -6.37 -0.36 8.28e-10 Response to iloperidone treatment (QT prolongation); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg22335246 chr12:120763591 PLA2G1B -0.39 -6.03 -0.35 5.61e-9 Vertical cup-disc ratio; CESC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC trans rs656319 0.638 rs670044 chr8:9892529 G/T cg15556689 chr8:8085844 FLJ10661 0.48 6.15 0.35 2.88e-9 Myopia (pathological); CESC cis rs10876993 0.821 rs1678522 chr12:58049923 G/A cg18357645 chr12:58087776 OS9 0.6 9.2 0.49 1.1e-17 Celiac disease or Rheumatoid arthritis; CESC cis rs9291683 0.552 rs10939655 chr4:10014642 A/T cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.5e-12 Bone mineral density; CESC cis rs7243790 1.000 rs17473264 chr18:51962904 T/C cg04730925 chr18:51795821 POLI -0.42 -5.54 -0.32 7.12e-8 Diastolic blood pressure; CESC cis rs7560272 0.564 rs4852939 chr2:73856769 C/G cg20560298 chr2:73613845 ALMS1 -0.51 -7.2 -0.4 6.12e-12 Schizophrenia; CESC cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg10523679 chr1:76189770 ACADM 0.76 9.96 0.52 4.53e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7772486 0.743 rs1292339 chr6:145967086 C/T cg05347473 chr6:146136440 FBXO30 -0.48 -6.34 -0.36 9.8e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg18538332 chr22:24372958 LOC391322 -0.72 -10.45 -0.54 1.26e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.48 -6.18 -0.35 2.39e-9 Tonsillectomy; CESC cis rs2228479 0.850 rs62052660 chr16:89847420 T/A cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.8e-7 Skin colour saturation; CESC cis rs9300255 0.602 rs2851450 chr12:123703501 C/T cg05973401 chr12:123451056 ABCB9 0.5 5.68 0.33 3.48e-8 Neutrophil percentage of white cells; CESC cis rs1620921 0.505 rs9458025 chr6:161203435 T/C cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg14347670 chr6:41908995 CCND3 -0.48 -6.43 -0.37 5.93e-10 Height; CESC cis rs8014204 0.901 rs4899536 chr14:75316614 A/G cg08847533 chr14:75593920 NEK9 -0.5 -6.34 -0.36 9.88e-10 Caffeine consumption; CESC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg16049864 chr8:95962084 TP53INP1 -0.68 -12.35 -0.6 5.62e-28 Type 2 diabetes; CESC cis rs17125944 0.505 rs118053951 chr14:53259829 G/A cg00686598 chr14:53173677 PSMC6 1.36 11.53 0.58 3.33e-25 Alzheimer's disease (late onset); CESC cis rs8017423 0.967 rs11628812 chr14:90713720 G/T cg14092571 chr14:90743983 NA 0.59 8.8 0.48 1.75e-16 Mortality in heart failure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16278828 chr15:75648574 MAN2C1 0.41 6.21 0.36 2.01e-9 Fibrinogen levels; CESC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg23048001 chr7:2026167 MAD1L1 0.45 5.85 0.34 1.48e-8 Schizophrenia; CESC cis rs6951245 0.882 rs11764817 chr7:1064610 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.45 -5.34 -0.31 2.04e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12291225 0.679 rs4757245 chr11:14297872 A/C cg19336497 chr11:14380999 RRAS2 -0.37 -5.27 -0.31 2.79e-7 Sense of smell; CESC cis rs2777491 0.957 rs2015781 chr15:41648967 C/G cg18705301 chr15:41695430 NDUFAF1 -0.62 -9.57 -0.51 8.12e-19 Ulcerative colitis; CESC cis rs72945132 0.882 rs7129843 chr11:70180381 G/A cg00319359 chr11:70116639 PPFIA1 0.74 7.16 0.4 7.98e-12 Coronary artery disease; CESC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg23283495 chr1:209979779 IRF6 0.52 7.39 0.41 1.9e-12 Cleft lip with or without cleft palate; CESC cis rs11098499 0.743 rs11098501 chr4:120252017 T/G cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg24578937 chr1:2090814 PRKCZ -0.35 -6.2 -0.36 2.12e-9 Height; CESC cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7527798 0.592 rs2025372 chr1:207829653 T/G cg21110645 chr1:207815933 NA -0.33 -5.81 -0.34 1.81e-8 Erythrocyte sedimentation rate; CESC trans rs561341 0.609 rs2051810 chr17:30195841 C/T cg20587970 chr11:113659929 NA 0.57 6.94 0.39 2.95e-11 Hip circumference adjusted for BMI; CESC cis rs4332037 0.539 rs3823624 chr7:2110346 T/C cg02743256 chr7:2109353 MAD1L1 -0.49 -5.22 -0.31 3.54e-7 Bipolar disorder; CESC cis rs6546550 0.935 rs3771541 chr2:70031797 C/G cg02498382 chr2:70120550 SNRNP27 -0.38 -6.5 -0.37 4.04e-10 Prevalent atrial fibrillation; CESC cis rs4835473 0.864 rs13117932 chr4:144657026 G/T cg25736465 chr4:144833511 NA -0.33 -5.2 -0.3 3.99e-7 Immature fraction of reticulocytes; CESC cis rs16854884 0.837 rs4362712 chr3:143801076 G/A cg06585982 chr3:143692056 C3orf58 0.43 5.31 0.31 2.37e-7 Economic and political preferences (feminism/equality); CESC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg23048001 chr7:2026167 MAD1L1 0.45 5.74 0.33 2.61e-8 Bipolar disorder and schizophrenia; CESC cis rs7586673 0.930 rs2884364 chr2:161977647 G/A cg22496339 chr2:162101262 NA 0.49 6.51 0.37 3.64e-10 Intelligence (multi-trait analysis); CESC cis rs9467711 0.606 rs34550936 chr6:26361985 A/G cg14345882 chr6:26364793 BTN3A2 0.61 6.49 0.37 4.31e-10 Autism spectrum disorder or schizophrenia; CESC cis rs9916302 0.821 rs1966915 chr17:37425262 A/C cg20243544 chr17:37824526 PNMT 0.46 5.76 0.33 2.31e-8 Glomerular filtration rate (creatinine); CESC cis rs1559088 0.576 rs10407255 chr19:33581150 A/G cg27124370 chr19:33622961 WDR88 -0.57 -8.58 -0.47 8.26e-16 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Depression; CESC cis rs1372520 0.684 rs356191 chr4:90688120 G/A cg15133208 chr4:90757351 SNCA 0.42 5.4 0.31 1.5e-7 Neuroticism; CESC cis rs3796352 1.000 rs11714876 chr3:53101640 C/G cg15956490 chr3:53032818 SFMBT1 -0.61 -5.33 -0.31 2.11e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg18512352 chr11:47633146 NA -0.6 -9.23 -0.49 8.67e-18 Subjective well-being; CESC cis rs911555 0.755 rs11620897 chr14:103944861 T/G cg12935359 chr14:103987150 CKB -0.57 -8.24 -0.45 7.75e-15 Intelligence (multi-trait analysis); CESC cis rs4595586 0.545 rs7973338 chr12:39380704 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg01351177 chr2:88991149 RPIA 0.5 6.99 0.39 2.17e-11 Systemic lupus erythematosus; CESC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg24060327 chr5:131705240 SLC22A5 0.43 5.26 0.31 2.99e-7 Blood metabolite levels; CESC cis rs67072384 0.818 rs7926287 chr11:72464525 A/G cg04827223 chr11:72435913 ARAP1 -0.61 -6.22 -0.36 1.97e-9 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs7084402 1.000 rs1427204 chr10:60267640 A/C cg07615347 chr10:60278583 BICC1 -0.61 -9.58 -0.51 7.18e-19 Refractive error; CESC cis rs2439831 0.867 rs12443102 chr15:43932103 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.83 8.45 0.46 1.91e-15 Lung cancer in ever smokers; CESC cis rs8020095 0.571 rs7141519 chr14:67524525 A/G cg19548862 chr14:67692701 FAM71D -0.5 -6.05 -0.35 4.95e-9 Depression (quantitative trait); CESC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg23758822 chr17:41437982 NA 1.01 15.21 0.68 5.44e-38 Menopause (age at onset); CESC cis rs4308124 0.708 rs6716091 chr2:111991133 C/T cg04571233 chr2:111982156 NA -0.6 -6.58 -0.37 2.54e-10 Vitiligo; CESC cis rs4604732 0.588 rs7549955 chr1:247628321 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.53 6.57 0.37 2.7e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg11494091 chr17:61959527 GH2 0.77 13.38 0.63 1.54e-31 Prudent dietary pattern; CESC cis rs2243480 1.000 rs316318 chr7:65612904 A/G cg12463550 chr7:65579703 CRCP 0.75 5.84 0.34 1.56e-8 Diabetic kidney disease; CESC cis rs929354 0.772 rs1182441 chr7:157026650 A/G cg05182265 chr7:156933206 UBE3C 0.5 7.33 0.41 2.87e-12 Body mass index; CESC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg18230493 chr5:56204884 C5orf35 -0.7 -8.48 -0.46 1.56e-15 Initial pursuit acceleration; CESC cis rs7666738 0.606 rs28481322 chr4:99086638 T/C cg05340658 chr4:99064831 C4orf37 0.65 9.03 0.49 3.66e-17 Colonoscopy-negative controls vs population controls; CESC cis rs804280 0.662 rs810738 chr8:11611206 A/G cg26752888 chr8:11627280 NEIL2 -0.67 -6.07 -0.35 4.38e-9 Myopia (pathological); CESC cis rs910316 0.967 rs2010678 chr14:75567178 C/T cg11812906 chr14:75593930 NEK9 0.91 15.5 0.69 5.27e-39 Height; CESC cis rs7084783 0.500 rs10883892 chr10:105397102 C/T cg00126946 chr10:105363258 SH3PXD2A 0.32 5.1 0.3 6.41e-7 Fear of pain; CESC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg23978390 chr7:1156363 C7orf50 0.48 6.38 0.36 8.01e-10 Longevity;Endometriosis; CESC cis rs7666738 0.822 rs9992360 chr4:98937123 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7301826 0.580 rs61938969 chr12:131316070 A/G cg11011512 chr12:131303247 STX2 -0.44 -5.26 -0.31 3.02e-7 Plasma plasminogen activator levels; CESC cis rs7937682 1.000 rs10502147 chr11:111569931 G/A cg09085632 chr11:111637200 PPP2R1B 1.03 14.07 0.65 5.86e-34 Primary sclerosing cholangitis; CESC cis rs637571 0.512 rs660118 chr11:65735174 G/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 5.92 0.34 9.86e-9 Eosinophil percentage of white cells; CESC trans rs60843830 1.000 rs10193373 chr2:281886 T/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 8.44 0.46 2.1e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs3771570 1.000 rs60209440 chr2:242260340 G/C cg21155796 chr2:242212141 HDLBP 0.6 5.05 0.3 8.15e-7 Prostate cancer; CESC cis rs2439831 1.000 rs689754 chr15:43775895 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.2 0.53 8.18e-21 Lung cancer in ever smokers; CESC cis rs6076065 0.748 rs999068 chr20:23376483 G/A cg11657817 chr20:23433608 CST11 0.4 6.1 0.35 3.7e-9 Facial morphology (factor 15, philtrum width); CESC cis rs7927592 0.956 rs11228277 chr11:68308324 G/A cg20283391 chr11:68216788 NA -0.5 -6.35 -0.36 9.36e-10 Total body bone mineral density; CESC trans rs17613427 1.000 rs111624850 chr2:142246560 T/G cg16810031 chr17:38024146 ZPBP2 -0.9 -6.25 -0.36 1.65e-9 Left ventricle systolic dysfunction; CESC cis rs2014572 0.967 rs10413671 chr19:57763489 G/A cg24459738 chr19:57751996 ZNF805 -0.53 -7.57 -0.42 6.02e-13 Hyperactive-impulsive symptoms; CESC cis rs11098499 0.954 rs7687843 chr4:120421211 C/T cg09307838 chr4:120376055 NA 0.92 12.98 0.62 3.83e-30 Corneal astigmatism; CESC cis rs6964587 1.000 rs7781066 chr7:91691946 G/T cg17063962 chr7:91808500 NA 0.59 8.2 0.45 1.03e-14 Breast cancer; CESC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg02353165 chr6:42928485 GNMT -0.61 -9.25 -0.49 8.01e-18 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg16132339 chr22:24313637 DDTL;DDT 0.42 6.41 0.37 6.65e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs208520 1.000 rs12190773 chr6:66968194 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 9.42 0.5 2.36e-18 Exhaled nitric oxide output; CESC cis rs1816752 1.000 rs7988810 chr13:25019096 T/C cg02811702 chr13:24901961 NA 0.39 5.63 0.33 4.52e-8 Obesity-related traits; CESC cis rs763121 0.853 rs5995610 chr22:39064681 C/T cg14440974 chr22:39074834 NA -0.42 -5.82 -0.34 1.69e-8 Menopause (age at onset); CESC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.42 -5.35 -0.31 1.9e-7 Tonsillectomy; CESC cis rs8058578 1.000 rs7187359 chr16:30703155 G/A cg02466173 chr16:30829666 NA -0.4 -6.38 -0.36 8.06e-10 Multiple myeloma; CESC cis rs4481887 1.000 rs11204636 chr1:248492409 A/C cg00666640 chr1:248458726 OR2T12 -0.39 -6.85 -0.39 5.1e-11 Common traits (Other); CESC cis rs6912958 0.712 rs7746465 chr6:88348996 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.24 -0.31 3.32e-7 Monocyte percentage of white cells; CESC cis rs473651 0.904 rs62196716 chr2:239356977 C/G cg21699342 chr2:239360505 ASB1 0.58 10.22 0.53 7.17e-21 Multiple system atrophy; CESC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.38 5.34 0.31 1.97e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05590616 chr11:59522917 STX3 0.55 6.1 0.35 3.69e-9 Gut microbiome composition (summer); CESC cis rs7814319 0.674 rs7836698 chr8:97242849 C/T cg20787634 chr8:97240163 UQCRB -0.55 -6.47 -0.37 4.6e-10 Lung function (FVC); CESC cis rs61774743 0.557 rs4359027 chr1:41848296 G/A cg08462924 chr1:41848221 NA 0.45 6.24 0.36 1.69e-9 Intelligence (multi-trait analysis); CESC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg12419862 chr22:24373484 LOC391322 -0.59 -8.07 -0.44 2.41e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs10435719 0.899 rs11250177 chr8:11799099 G/A cg15556689 chr8:8085844 FLJ10661 0.54 6.73 0.38 1.03e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC trans rs13035304 0.773 rs7586873 chr2:130507396 A/G cg18827756 chr15:42130735 JMJD7-PLA2G4B;PLA2G4B -0.41 -6.7 -0.38 1.28e-10 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg27494647 chr7:150038898 RARRES2 0.43 5.16 0.3 4.84e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg26314531 chr2:26401878 FAM59B -0.85 -8.91 -0.48 8.54e-17 Gut microbiome composition (summer); CESC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg16145915 chr7:1198662 ZFAND2A -0.56 -8.7 -0.47 3.69e-16 Longevity;Endometriosis; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg26354017 chr1:205819088 PM20D1 1.01 18.11 0.74 3.04e-48 Menarche (age at onset); CESC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.64 0.47 5.5e-16 Menopause (age at onset); CESC cis rs4555082 0.957 rs2816628 chr14:105736134 T/G cg06808227 chr14:105710500 BRF1 -0.54 -6.86 -0.39 4.88e-11 Mean platelet volume;Platelet distribution width; CESC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Parkinson's disease; CESC cis rs7618501 0.516 rs2856236 chr3:50161717 A/C cg24308560 chr3:49941425 MST1R 0.57 8.04 0.44 3.06e-14 Intelligence (multi-trait analysis); CESC cis rs8114671 0.528 rs6119542 chr20:33484545 G/T cg24642439 chr20:33292090 TP53INP2 0.43 5.19 0.3 4.19e-7 Height; CESC trans rs62103177 0.759 rs7227794 chr18:77610925 C/T cg05926928 chr17:57297772 GDPD1 1.16 11.61 0.58 1.88e-25 Opioid sensitivity; CESC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg22920501 chr2:26401640 FAM59B -0.84 -10.1 -0.53 1.72e-20 Gut microbiome composition (summer); CESC cis rs6736093 0.932 rs77096506 chr2:112657554 T/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.17 -0.3 4.56e-7 Coronary artery disease; CESC cis rs8114671 0.562 rs4911161 chr20:33402231 C/T cg07148914 chr20:33460835 GGT7 0.45 5.9 0.34 1.1e-8 Height; CESC cis rs4971059 0.629 rs4246529 chr1:155115260 T/C cg22049894 chr1:155113146 DPM3 0.46 5.91 0.34 1.06e-8 Breast cancer; CESC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg22920501 chr2:26401640 FAM59B -0.63 -7.49 -0.42 1e-12 Gut microbiome composition (summer); CESC cis rs9858542 0.953 rs9853683 chr3:49512588 A/G cg03060546 chr3:49711283 APEH -0.54 -6.12 -0.35 3.44e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg19726959 chr15:75094782 CSK -0.49 -6.09 -0.35 3.99e-9 Psoriatic arthritis; CESC cis rs6121246 0.559 rs6119650 chr20:30258480 C/A cg13852791 chr20:30311386 BCL2L1 0.79 10.1 0.53 1.74e-20 Mean corpuscular hemoglobin; CESC cis rs9300255 0.537 rs1727334 chr12:123714236 A/G cg00376283 chr12:123451042 ABCB9 0.72 8.84 0.48 1.34e-16 Neutrophil percentage of white cells; CESC cis rs6500395 0.775 rs4277341 chr16:48664387 T/G cg04672837 chr16:48644449 N4BP1 0.49 6.27 0.36 1.46e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg22920501 chr2:26401640 FAM59B -0.79 -9.3 -0.5 5.61e-18 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg23708337 chr7:1209742 NA 0.55 5.42 0.32 1.33e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2408955 0.522 rs4760679 chr12:48461635 G/T cg24011408 chr12:48396354 COL2A1 -0.49 -7.41 -0.41 1.74e-12 Glycated hemoglobin levels; CESC cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg26939375 chr7:64535504 NA -0.74 -10.63 -0.55 3.13e-22 Aortic root size; CESC cis rs11252926 0.770 rs2124585 chr10:680428 G/A cg08603382 chr10:743973 NA 0.4 5.56 0.32 6.62e-8 Psychosis in Alzheimer's disease; CESC cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.12 12.71 0.62 3.1e-29 Smoking behavior; CESC cis rs9910055 0.615 rs189049 chr17:42197213 A/C cg08499158 chr17:42289980 UBTF 0.51 6.47 0.37 4.62e-10 Total body bone mineral density; CESC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg00484396 chr16:3507460 NAT15 0.42 6.79 0.38 7.34e-11 Tuberculosis; CESC cis rs769267 0.864 rs7245983 chr19:19657632 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.45 5.61 0.33 4.99e-8 Tonsillectomy; CESC cis rs7274811 0.688 rs6141400 chr20:32056087 C/T cg21523528 chr20:32077966 CBFA2T2 0.58 6.93 0.39 3.19e-11 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15947099 chr10:70481448 CCAR1 0.52 6.04 0.35 5.18e-9 Gut microbiome composition (summer); CESC cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg24838063 chr12:130822603 PIWIL1 0.73 9.31 0.5 5.11e-18 Menopause (age at onset); CESC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg13206674 chr6:150067644 NUP43 0.41 5.66 0.33 3.88e-8 Lung cancer; CESC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 14.04 0.65 7.76e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg02951883 chr7:2050386 MAD1L1 -0.51 -6.88 -0.39 4.26e-11 Bipolar disorder and schizophrenia; CESC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg07677032 chr17:61819896 STRADA -0.41 -5.25 -0.31 3.11e-7 Height; CESC cis rs72781680 0.611 rs72797810 chr2:24336469 G/A cg20701182 chr2:24300061 SF3B14 0.91 10.51 0.54 7.88e-22 Lymphocyte counts; CESC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg21951975 chr1:209979733 IRF6 0.54 6.35 0.36 9.15e-10 Cleft lip with or without cleft palate; CESC cis rs11122272 0.701 rs2011383 chr1:231479788 T/A cg06096015 chr1:231504339 EGLN1 0.43 6.41 0.37 6.78e-10 Hemoglobin concentration; CESC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.15e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9323205 0.953 rs61144314 chr14:51620556 G/A cg23942311 chr14:51606299 NA -0.44 -5.7 -0.33 3.21e-8 Cancer; CESC cis rs1062177 0.855 rs919262 chr5:151266084 C/T cg12924095 chr5:151150029 G3BP1 -0.45 -6.16 -0.35 2.71e-9 Preschool internalizing problems; CESC cis rs17253792 0.822 rs9972180 chr14:56073732 G/T cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg08888203 chr3:10149979 C3orf24 0.44 5.6 0.33 5.31e-8 Alzheimer's disease; CESC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg01416388 chr22:39784598 NA -0.58 -7.21 -0.4 6.02e-12 Intelligence (multi-trait analysis); CESC trans rs637571 0.565 rs633800 chr11:65638719 G/A cg17712092 chr4:129076599 LARP1B -0.7 -8.88 -0.48 1.02e-16 Eosinophil percentage of white cells; CESC cis rs4243830 0.850 rs4908910 chr1:6599362 T/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.86 -7.53 -0.42 7.77e-13 Body mass index; CESC cis rs7605827 0.897 rs7567750 chr2:15690412 C/T cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs7582720 0.943 rs72926798 chr2:203827675 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs2066819 1.000 rs41423244 chr12:56693520 A/C cg26804944 chr12:56660921 COQ10A 0.87 5.3 0.31 2.45e-7 Psoriasis vulgaris; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06995624 chr17:73043174 ATP5H;KCTD2 -0.5 -6.63 -0.38 1.88e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11785400 0.701 rs9721143 chr8:143727511 A/T cg24634471 chr8:143751801 JRK 0.46 5.82 0.34 1.73e-8 Schizophrenia; CESC cis rs10865397 0.539 rs13414338 chr2:73383375 C/T cg01422370 chr2:73384389 NA 0.47 7.47 0.42 1.15e-12 Intelligence (multi-trait analysis); CESC cis rs7927592 0.763 rs7129248 chr11:68263276 A/T cg20283391 chr11:68216788 NA -0.44 -5.47 -0.32 1.06e-7 Total body bone mineral density; CESC cis rs2760061 0.819 rs708112 chr1:228192452 G/A cg18477163 chr1:228402036 OBSCN 0.31 5.5 0.32 9.1e-8 Diastolic blood pressure; CESC cis rs4319547 0.586 rs7956480 chr12:122817507 A/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -5.52 -0.32 8.2e-8 Body mass index; CESC cis rs116095464 0.558 rs62347678 chr5:227496 A/G cg10591111 chr5:226296 SDHA -0.53 -6.65 -0.38 1.64e-10 Breast cancer; CESC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg00149659 chr3:10157352 C3orf10 0.7 8.31 0.45 5.08e-15 Alzheimer's disease; CESC cis rs13082711 0.911 rs17682751 chr3:27497027 C/T cg02860705 chr3:27208620 NA -0.54 -6.75 -0.38 9.43e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg26035463 chr12:117627651 FBXO21 -0.56 -6.09 -0.35 3.92e-9 Subjective well-being; CESC cis rs853679 0.546 rs35353359 chr6:28324378 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.84 5.51 0.32 8.48e-8 Depression; CESC cis rs74781061 0.929 rs12442097 chr15:74847133 A/C cg17294928 chr15:75287854 SCAMP5 -0.49 -5.24 -0.31 3.28e-7 Endometriosis; CESC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC cis rs7772486 0.686 rs4896827 chr6:145953338 T/A cg23711669 chr6:146136114 FBXO30 0.92 13.65 0.64 1.81e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs17376456 0.877 rs9314099 chr5:93447375 T/C cg25358565 chr5:93447407 FAM172A 1.15 11.8 0.59 4.11e-26 Diabetic retinopathy; CESC cis rs7267979 1.000 rs8125868 chr20:25324410 A/G cg08601574 chr20:25228251 PYGB -0.37 -5.36 -0.31 1.81e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg16339924 chr4:17578868 LAP3 -0.82 -10.32 -0.54 3.28e-21 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4523957 0.928 rs170044 chr17:2197502 C/G cg16513277 chr17:2031491 SMG6 -0.57 -7.7 -0.43 2.79e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg03709012 chr19:19516395 GATAD2A 0.95 13.98 0.65 1.22e-33 Tonsillectomy; CESC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg08027265 chr7:2291960 NA -0.41 -6.08 -0.35 4.22e-9 Bipolar disorder and schizophrenia; CESC cis rs959260 0.688 rs9899687 chr17:73358259 C/T cg20590849 chr17:73267439 MIF4GD -0.56 -6.11 -0.35 3.55e-9 Systemic lupus erythematosus; CESC cis rs71403859 0.614 rs12935422 chr16:71664225 T/A cg08717414 chr16:71523259 ZNF19 -0.69 -5.94 -0.34 9.1e-9 Post bronchodilator FEV1; CESC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg18404041 chr3:52824283 ITIH1 -0.39 -6.64 -0.38 1.81e-10 Bipolar disorder; CESC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg00750074 chr16:89608354 SPG7 -0.41 -6.05 -0.35 4.84e-9 Multiple myeloma (IgH translocation); CESC cis rs7647973 0.771 rs9865051 chr3:49166069 C/T cg07636037 chr3:49044803 WDR6 0.9 11.4 0.57 8.91e-25 Menarche (age at onset); CESC cis rs35995292 0.534 rs917322 chr7:38943165 A/T cg19327137 chr7:38886074 VPS41 -0.65 -10.64 -0.55 2.96e-22 Subjective well-being (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26726542 chr13:20702031 NA 0.54 6.62 0.38 2e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06528150 chr2:61293470 KIAA1841 0.54 6.2 0.36 2.17e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.744 rs9627278 chr22:46643432 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.49 5.12 0.3 5.79e-7 LDL cholesterol;Cholesterol, total; CESC cis rs17601876 0.807 rs12910259 chr15:51555049 G/A cg19946085 chr15:51559439 CYP19A1 -0.34 -5.29 -0.31 2.52e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs3820928 1.000 rs4675120 chr2:227774888 C/T cg05526886 chr2:227700861 RHBDD1 -0.44 -5.75 -0.33 2.45e-8 Pulmonary function; CESC cis rs3087591 1.000 rs2905795 chr17:29547601 A/G cg24425628 chr17:29625626 OMG;NF1 0.42 5.11 0.3 6.32e-7 Hip circumference; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03582286 chr4:71571171 RUFY3 0.57 6.79 0.38 7.25e-11 Gut microbiome composition (summer); CESC cis rs3793683 0.597 rs12783367 chr10:134587334 T/C cg18305652 chr10:134549665 INPP5A 0.48 6.82 0.39 6.13e-11 Migraine; CESC cis rs1348850 0.958 rs4893941 chr2:178269531 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.88 12.78 0.62 1.88e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg00612595 chr21:47717864 NA 0.41 5.57 0.32 6.27e-8 Testicular germ cell tumor; CESC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg17143192 chr8:8559678 CLDN23 0.44 5.37 0.31 1.74e-7 Mood instability; CESC cis rs1577917 0.958 rs1335442 chr6:86466692 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -6.84 -0.39 5.52e-11 Response to antipsychotic treatment; CESC cis rs6752107 0.791 rs3792106 chr2:234190740 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.44 5.91 0.34 1.04e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs2070488 0.775 rs6780349 chr3:38555178 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.76 -12.23 -0.6 1.43e-27 Electrocardiographic conduction measures; CESC cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg11502198 chr6:26597334 ABT1 0.52 5.34 0.31 1.99e-7 Intelligence (multi-trait analysis); CESC cis rs72781680 0.665 rs2675356 chr2:24074734 C/T cg08917208 chr2:24149416 ATAD2B 0.63 6.28 0.36 1.41e-9 Lymphocyte counts; CESC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg21784768 chr11:537496 LRRC56 -0.55 -5.13 -0.3 5.71e-7 Body mass index; CESC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg06873352 chr17:61820015 STRADA 0.48 6.88 0.39 4.26e-11 Height; CESC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg27503950 chr6:160024002 NA 0.35 5.08 0.3 7.22e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs2732480 0.577 rs2634691 chr12:48708259 G/T cg24011408 chr12:48396354 COL2A1 0.43 5.97 0.34 7.7e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg24675658 chr1:53192096 ZYG11B 0.53 6.69 0.38 1.29e-10 Monocyte count; CESC cis rs1983891 1.000 rs9381082 chr6:41542214 T/C cg20194872 chr6:41519635 FOXP4 0.55 7.76 0.43 1.88e-13 Prostate cancer; CESC cis rs2074409 0.571 rs67499664 chr17:35893645 T/A cg16670864 chr17:35848621 DUSP14 0.43 5.16 0.3 4.87e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs4727963 0.792 rs1525469 chr7:122718038 A/G cg03640110 chr7:122635026 TAS2R16 0.41 6.65 0.38 1.67e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs9303280 0.806 rs35569035 chr17:38035624 C/T cg20243544 chr17:37824526 PNMT 0.53 6.96 0.39 2.6e-11 Self-reported allergy; CESC cis rs67311347 0.824 rs73073561 chr3:40357298 G/T cg24209194 chr3:40518798 ZNF619 0.4 5.04 0.3 8.46e-7 Renal cell carcinoma; CESC cis rs8114671 0.869 rs1407202 chr20:33651967 C/T cg06115741 chr20:33292138 TP53INP2 -0.45 -5.44 -0.32 1.23e-7 Height; CESC cis rs6032067 0.714 rs35770435 chr20:43788804 C/T cg11264863 chr20:43835661 SEMG1 0.51 5.46 0.32 1.11e-7 Blood protein levels; CESC cis rs6121246 0.529 rs7261354 chr20:30202414 T/C cg13852791 chr20:30311386 BCL2L1 0.66 6.6 0.38 2.23e-10 Mean corpuscular hemoglobin; CESC cis rs7772486 0.622 rs1292333 chr6:145982344 C/T cg05347473 chr6:146136440 FBXO30 -0.55 -7.23 -0.41 5.17e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg14664628 chr15:75095509 CSK -0.59 -8.12 -0.45 1.77e-14 Breast cancer; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg11922607 chr18:21083993 C18orf8 -0.41 -6.12 -0.35 3.41e-9 Vertical cup-disc ratio; CESC cis rs7312933 0.558 rs3747560 chr12:42719890 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.4 -0.37 7.09e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg23172400 chr8:95962367 TP53INP1 -0.44 -9.21 -0.49 1e-17 Type 2 diabetes; CESC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.54 -6.65 -0.38 1.63e-10 Prudent dietary pattern; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06713297 chr1:242011104 EXO1 0.53 7.19 0.4 6.48e-12 Systemic lupus erythematosus; CESC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg07395648 chr5:131743802 NA -0.43 -5.64 -0.33 4.38e-8 Breast cancer; CESC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -6.88 -0.39 4.39e-11 Bipolar disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20029123 chr22:30783486 RNF215 -0.47 -6.14 -0.35 2.99e-9 Ulcerative colitis; CESC cis rs713587 0.563 rs1529897 chr2:25086827 T/G cg01884057 chr2:25150051 NA 0.34 6.36 0.36 8.88e-10 Body mass index in non-asthmatics; CESC cis rs2479724 0.811 rs8393 chr6:41757836 C/A cg17623882 chr6:41773611 USP49 0.41 5.57 0.32 6.41e-8 Menarche (age at onset); CESC cis rs12220238 1.000 rs1908331 chr10:75885817 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.52 0.37 3.45e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs941408 0.515 rs1640265 chr19:2784405 C/T cg02580895 chr19:2754563 NA -0.48 -6.56 -0.37 2.73e-10 Total cholesterol levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24274347 chr12:132497611 EP400 0.51 7.0 0.4 2.07e-11 Fibrinogen levels; CESC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg05863683 chr7:1912471 MAD1L1 0.42 6.2 0.36 2.2e-9 Bipolar disorder and schizophrenia; CESC cis rs6912958 0.712 rs4498321 chr6:88339251 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.72 -0.38 1.09e-10 Monocyte percentage of white cells; CESC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg12667521 chr19:29218732 NA 0.49 6.35 0.36 9.47e-10 Methadone dose in opioid dependence; CESC cis rs4820539 1.000 rs885965 chr22:23461425 A/G cg14186256 chr22:23484241 RTDR1 0.83 14.44 0.66 2.92e-35 Bone mineral density; CESC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg18404041 chr3:52824283 ITIH1 -0.44 -7.28 -0.41 3.87e-12 Bipolar disorder; CESC cis rs3857536 0.740 rs9342532 chr6:66886297 T/C cg07460842 chr6:66804631 NA -0.42 -5.39 -0.31 1.53e-7 Blood trace element (Cu levels); CESC cis rs67311347 1.000 rs1466236 chr3:40462162 C/T cg09455208 chr3:40491958 NA 0.45 7.93 0.44 6.31e-14 Renal cell carcinoma; CESC cis rs916888 0.773 rs199451 chr17:44801784 G/A cg27589368 chr17:43923255 LOC100128977;IMP5 -0.39 -5.28 -0.31 2.72e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs708547 0.647 rs1713982 chr4:57881715 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.47 6.61 0.38 2.11e-10 Response to bleomycin (chromatid breaks); CESC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.38 0.31 1.68e-7 Menopause (age at onset); CESC cis rs7100689 0.646 rs2039757 chr10:82078868 C/A cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 4.91e-14 Post bronchodilator FEV1; CESC cis rs8141529 0.778 rs5762795 chr22:29182500 C/A cg15103426 chr22:29168792 CCDC117 0.68 9.79 0.52 1.59e-19 Lymphocyte counts; CESC cis rs9314323 0.798 rs12682345 chr8:26218332 A/G cg13160058 chr8:26243215 BNIP3L 0.32 5.13 0.3 5.53e-7 Red cell distribution width; CESC cis rs7607369 0.718 rs6727147 chr2:219639024 G/A cg02176678 chr2:219576539 TTLL4 -0.43 -7.65 -0.43 3.62e-13 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 5.42 0.32 1.37e-7 Tonsillectomy; CESC cis rs36051895 0.623 rs76960049 chr9:5064548 G/A cg02405213 chr9:5042618 JAK2 -0.47 -5.89 -0.34 1.14e-8 Pediatric autoimmune diseases; CESC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg25072359 chr17:41440525 NA 0.43 5.78 0.33 2.04e-8 Menopause (age at onset); CESC cis rs7520050 0.966 rs10749860 chr1:46328210 C/G cg24296786 chr1:45957014 TESK2 0.42 5.37 0.31 1.69e-7 Red blood cell count;Reticulocyte count; CESC cis rs1538970 0.924 rs12097497 chr1:45880669 C/T cg24296786 chr1:45957014 TESK2 -0.45 -5.28 -0.31 2.65e-7 Platelet count; CESC trans rs11039798 0.588 rs113800184 chr11:48756855 G/A cg15704280 chr7:45808275 SEPT13 0.65 6.5 0.37 4.05e-10 Axial length; CESC cis rs7267979 1.000 rs2258719 chr20:25275843 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.84 16.05 0.7 5.98e-41 Liver enzyme levels (alkaline phosphatase); CESC trans rs1814175 0.616 rs10769644 chr11:49987676 C/A cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs77106637 0.932 rs74439784 chr11:72649396 A/T cg03713592 chr11:72463424 ARAP1 1.07 9.88 0.52 8.17e-20 Type 2 diabetes; CESC trans rs9929218 0.748 rs34592833 chr16:68739125 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -8.79 -0.48 1.92e-16 Colorectal cancer; CESC cis rs1568889 0.838 rs4572130 chr11:28371794 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.82 13.76 0.65 6.99e-33 Bipolar disorder; CESC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg11965913 chr1:205819406 PM20D1 0.82 13.45 0.64 8.74e-32 Menarche (age at onset); CESC cis rs6537837 1.000 rs7355157 chr1:110129835 T/C cg05049280 chr1:110155535 GNAT2 0.38 5.32 0.31 2.17e-7 Major depressive disorder; CESC cis rs2180341 0.538 rs3756993 chr6:127651551 A/C cg27446573 chr6:127587934 RNF146 0.63 8.57 0.47 8.45e-16 Breast cancer; CESC cis rs2932538 0.922 rs12750621 chr1:113206502 G/C cg22162597 chr1:113214053 CAPZA1 0.61 7.42 0.41 1.55e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs1348850 0.574 rs2365617 chr2:178421934 C/A cg23306229 chr2:178417860 TTC30B 0.79 6.97 0.39 2.45e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6582630 0.502 rs1589390 chr12:38416139 C/T cg26384229 chr12:38710491 ALG10B -0.4 -5.32 -0.31 2.24e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs9467773 0.620 rs2504567 chr6:26662920 C/G cg20266910 chr6:26577678 NA 0.35 5.67 0.33 3.79e-8 Intelligence (multi-trait analysis); CESC cis rs2637266 0.783 rs720249 chr10:78476143 T/C cg18941641 chr10:78392320 NA 0.44 8.37 0.46 3.29e-15 Pulmonary function; CESC cis rs910316 1.000 rs4903289 chr14:75623988 C/T cg11812906 chr14:75593930 NEK9 -0.91 -16.2 -0.71 1.69e-41 Height; CESC cis rs7937682 0.881 rs4936678 chr11:111625085 C/T cg22437258 chr11:111473054 SIK2 -0.56 -5.28 -0.31 2.76e-7 Primary sclerosing cholangitis; CESC cis rs116095464 0.558 rs2288458 chr5:231260 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.5 -0.46 1.44e-15 Breast cancer; CESC cis rs2573652 1.000 rs12441080 chr15:100516968 A/G cg00587665 chr15:100533223 ADAMTS17 0.36 5.84 0.34 1.54e-8 Height; CESC trans rs17428076 0.836 rs12053046 chr2:172673399 A/G cg14287618 chr9:37440492 ZBTB5 0.47 6.01 0.35 6.13e-9 Myopia; CESC trans rs10242455 0.702 rs73711293 chr7:99081595 C/T cg09045935 chr12:6379348 NA 0.88 6.81 0.39 6.62e-11 Blood metabolite levels; CESC cis rs2481665 0.777 rs17379217 chr1:62545085 C/T cg18591186 chr1:62594603 INADL -0.43 -5.08 -0.3 7.16e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs477692 0.905 rs524545 chr10:131411840 A/C cg05714579 chr10:131428358 MGMT -0.53 -7.36 -0.41 2.3e-12 Response to temozolomide; CESC cis rs10779751 0.922 rs2295080 chr1:11322628 G/T cg08854313 chr1:11322531 MTOR 0.93 14.76 0.67 2.21e-36 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24936468 chr1:25663368 TMEM50A 0.48 6.52 0.37 3.61e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs708547 0.624 rs1718886 chr4:57849251 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.55 -7.52 -0.42 8.66e-13 Response to bleomycin (chromatid breaks); CESC cis rs4319547 0.956 rs10744275 chr12:123048618 A/G cg05707623 chr12:122985044 ZCCHC8 -0.58 -6.41 -0.37 6.77e-10 Body mass index; CESC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.7 -7.98 -0.44 4.48e-14 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07419830 chr16:3332899 ZNF263 0.62 7.2 0.4 6.22e-12 Gut microbiome composition (summer); CESC cis rs6163 0.588 rs10786706 chr10:104500659 C/T cg04362960 chr10:104952993 NT5C2 0.4 5.45 0.32 1.15e-7 Waist circumference;Hip circumference; CESC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg20243544 chr17:37824526 PNMT 0.49 6.23 0.36 1.85e-9 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC trans rs1373453 0.808 rs117805570 chr12:70069098 C/T cg19702771 chr4:82058885 PRKG2 0.74 6.04 0.35 5.28e-9 Orofacial clefts; CESC cis rs2072732 0.706 rs112690788 chr1:2954055 A/G cg15211996 chr1:2936768 ACTRT2 0.34 5.78 0.33 2.08e-8 Plateletcrit; CESC cis rs17376456 0.877 rs28575883 chr5:93346035 T/C cg21475434 chr5:93447410 FAM172A 0.77 6.74 0.38 9.6e-11 Diabetic retinopathy; CESC cis rs763121 0.889 rs9610971 chr22:38910810 C/T cg06022373 chr22:39101656 GTPBP1 0.78 11.1 0.56 9.56e-24 Menopause (age at onset); CESC cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg05340658 chr4:99064831 C4orf37 0.82 13.05 0.63 2.08e-30 Colonoscopy-negative controls vs population controls; CESC cis rs35146811 0.555 rs2525539 chr7:99545309 A/G cg14163444 chr7:99595348 NA 0.4 5.13 0.3 5.67e-7 Coronary artery disease; CESC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg05872129 chr22:39784769 NA -0.85 -11.73 -0.58 7.18e-26 Intelligence (multi-trait analysis); CESC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg19163074 chr7:65112434 INTS4L2 -0.44 -5.3 -0.31 2.41e-7 Calcium levels; CESC cis rs2228479 0.850 rs1108063 chr16:89893983 A/G cg00800038 chr16:89945340 TCF25 -0.86 -6.89 -0.39 3.98e-11 Skin colour saturation; CESC cis rs7247513 0.897 rs12979146 chr19:12717904 C/T cg11738485 chr19:12877000 HOOK2 0.41 5.07 0.3 7.56e-7 Bipolar disorder; CESC cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg00750074 chr16:89608354 SPG7 -0.38 -5.51 -0.32 8.31e-8 Multiple myeloma (IgH translocation); CESC cis rs7662987 1.000 rs1061187 chr4:99992853 G/A cg13256891 chr4:100009986 ADH5 -0.83 -5.91 -0.34 1.04e-8 Smoking initiation; CESC cis rs1707322 0.717 rs3014246 chr1:46086077 C/T cg06784218 chr1:46089804 CCDC17 -0.4 -6.93 -0.39 3.29e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7582720 1.000 rs72926787 chr2:203818299 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs11098499 0.909 rs28793658 chr4:120307214 A/C cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg03351412 chr1:154909251 PMVK 0.69 9.39 0.5 2.91e-18 Prostate cancer; CESC cis rs1707322 1.000 rs7532204 chr1:46485075 C/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.6 -0.33 5.27e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs34779708 0.966 rs1545757 chr10:35445588 A/T cg04310649 chr10:35416472 CREM -0.51 -6.18 -0.35 2.39e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg18876405 chr7:65276391 NA -0.53 -7.19 -0.4 6.46e-12 Aortic root size; CESC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg03647317 chr4:187891568 NA -0.39 -5.8 -0.34 1.88e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs96067 0.607 rs274761 chr1:36574023 C/T cg27506609 chr1:36549197 TEKT2 -0.44 -5.34 -0.31 1.97e-7 Corneal structure; CESC trans rs802075 0.905 rs2396918 chr6:49636027 A/T cg06254729 chr2:28550422 BRE -0.37 -6.32 -0.36 1.08e-9 Bone mineral density (hip) and age at menarche; CESC cis rs11649653 0.502 rs62057232 chr16:30820866 T/C cg00531865 chr16:30841666 NA 0.44 5.64 0.33 4.44e-8 Triglycerides; CESC trans rs9467711 0.606 rs9393705 chr6:26361011 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -6.87 -0.39 4.66e-11 Autism spectrum disorder or schizophrenia; CESC cis rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08668662 chr20:30539908 PDRG1 -0.44 -5.84 -0.34 1.52e-8 Ulcerative colitis; CESC cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg04944784 chr2:26401820 FAM59B 0.78 7.46 0.42 1.23e-12 Gut microbiome composition (summer); CESC cis rs561341 0.883 rs886224 chr17:30229902 T/C cg19193384 chr17:30244184 NA -0.56 -5.77 -0.33 2.16e-8 Hip circumference adjusted for BMI; CESC cis rs7243790 0.805 rs3809947 chr18:51906766 A/T cg04730925 chr18:51795821 POLI -0.42 -5.58 -0.32 6.04e-8 Diastolic blood pressure; CESC cis rs2050392 0.861 rs1042058 chr10:30728101 T/C cg18806716 chr10:30721971 MAP3K8 -0.4 -5.8 -0.34 1.86e-8 Inflammatory bowel disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24763869 chr17:3572311 TMEM93;TAX1BP3 -0.45 -6.15 -0.35 2.77e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg06873352 chr17:61820015 STRADA 0.73 13.07 0.63 1.78e-30 Prudent dietary pattern; CESC cis rs12701220 0.948 rs10275712 chr7:1082918 G/A cg26769984 chr7:1090371 C7orf50 0.7 8.06 0.44 2.64e-14 Bronchopulmonary dysplasia; CESC cis rs55728055 0.661 rs16989379 chr22:32058269 G/A cg01338084 chr22:32026380 PISD 1.26 8.24 0.45 8.13e-15 Age-related hearing impairment; CESC cis rs17601876 0.786 rs2414100 chr15:51562420 T/A cg19946085 chr15:51559439 CYP19A1 -0.33 -5.42 -0.32 1.33e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs2072732 0.904 rs717795 chr1:2970464 T/C cg03976712 chr1:2946727 NA 0.33 5.64 0.33 4.25e-8 Plateletcrit; CESC cis rs889312 0.500 rs702688 chr5:56190986 A/G cg12311346 chr5:56204834 C5orf35 -0.44 -5.44 -0.32 1.22e-7 Breast cancer;Breast cancer (early onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27587223 chr3:113822217 NA -0.58 -6.72 -0.38 1.11e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.840 rs11155451 chr6:146422524 A/G cg23711669 chr6:146136114 FBXO30 0.88 12.95 0.62 4.95e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs12824058 0.831 rs12297939 chr12:130811923 G/C cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs3749237 0.595 rs7637999 chr3:49535115 C/T cg07636037 chr3:49044803 WDR6 0.61 8.81 0.48 1.66e-16 Resting heart rate; CESC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.53 -7.02 -0.4 1.88e-11 Menarche (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09019002 chr7:102715232 ARMC10;FBXL13 -0.45 -6.62 -0.38 2.04e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7129220 0.588 rs16907462 chr11:10137404 T/C cg01453529 chr11:10209919 SBF2 -0.47 -5.5 -0.32 8.95e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs6540556 0.954 rs6540555 chr1:209936571 A/G cg05527609 chr1:210001259 C1orf107 -0.47 -5.88 -0.34 1.25e-8 Red blood cell count; CESC cis rs12477438 0.520 rs34252185 chr2:99737646 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.09 0.7 4.08e-41 Chronic sinus infection; CESC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg17366294 chr4:99064904 C4orf37 0.59 8.52 0.46 1.24e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2721195 0.874 rs2721173 chr8:145744429 C/T cg15320075 chr8:145703422 NA 0.56 7.88 0.44 8.48e-14 Age at first birth; CESC cis rs15676 0.783 rs2997917 chr9:131586918 G/A cg00228799 chr9:131580591 ENDOG 0.55 7.13 0.4 9.74e-12 Blood metabolite levels; CESC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs7000551 0.581 rs11136030 chr8:22254235 C/T cg12081754 chr8:22256438 SLC39A14 0.92 13.24 0.63 4.74e-31 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs7605827 0.930 rs7598196 chr2:15596662 A/G cg19274914 chr2:15703543 NA 0.33 5.97 0.34 7.72e-9 Educational attainment (years of education); CESC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs7851660 0.809 rs12006522 chr9:100652711 G/C cg13688889 chr9:100608707 NA -0.63 -8.96 -0.48 5.96e-17 Strep throat; CESC cis rs10751667 0.666 rs7105477 chr11:964271 C/G cg06064525 chr11:970664 AP2A2 -0.47 -9.27 -0.49 6.7e-18 Alzheimer's disease (late onset); CESC cis rs7605827 0.930 rs12692273 chr2:15688834 G/C cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs11997175 0.655 rs4380889 chr8:33663381 C/T ch.8.33884649F chr8:33765107 NA 0.48 6.21 0.36 2.06e-9 Body mass index; CESC cis rs916888 0.821 rs199506 chr17:44859031 A/G cg15921436 chr17:44337874 NA -0.71 -7.96 -0.44 5.06e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1953600 0.870 rs2788296 chr10:81937889 G/A cg00277334 chr10:82204260 NA 0.47 6.54 0.37 3.2e-10 Sarcoidosis; CESC cis rs13385 0.769 rs3822739 chr5:139625743 A/G cg26211634 chr5:139558579 C5orf32 0.47 5.2 0.3 3.94e-7 Atrial fibrillation; CESC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg06634786 chr22:41940651 POLR3H -0.69 -7.12 -0.4 1.01e-11 Vitiligo; CESC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg17372223 chr3:52568218 NT5DC2 0.51 7.92 0.44 6.62e-14 Electroencephalogram traits; CESC cis rs6991838 0.530 rs6472217 chr8:66547731 A/G cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs57502260 0.764 rs3867143 chr11:68223074 A/G cg20283391 chr11:68216788 NA -0.66 -5.76 -0.33 2.35e-8 Total body bone mineral density (age 45-60); CESC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.9 0.39 3.88e-11 Bipolar disorder; CESC cis rs9905704 0.836 rs170024 chr17:56831887 T/C cg12560992 chr17:57184187 TRIM37 0.63 7.76 0.43 1.87e-13 Testicular germ cell tumor; CESC cis rs8180040 0.966 rs11130137 chr3:47578838 C/T cg27129171 chr3:47204927 SETD2 0.63 9.36 0.5 3.65e-18 Colorectal cancer; CESC cis rs7208859 0.623 rs73271872 chr17:29152228 C/G cg13385521 chr17:29058706 SUZ12P 0.75 6.0 0.35 6.29e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2014572 0.967 rs8112572 chr19:57759612 T/C cg24459738 chr19:57751996 ZNF805 -0.54 -7.57 -0.42 6.06e-13 Hyperactive-impulsive symptoms; CESC cis rs3796352 1.000 rs34340609 chr3:53077276 A/G cg12962167 chr3:53033115 SFMBT1 0.55 5.48 0.32 1e-7 Immune reponse to smallpox (secreted IL-2); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07589143 chr5:54603461 DHX29;SKIV2L2 0.52 6.03 0.35 5.4e-9 Gut microbiome composition (summer); CESC cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg27347728 chr4:17578864 LAP3 -0.49 -5.64 -0.33 4.42e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6982240 0.514 rs10481391 chr8:142277149 A/G cg27411547 chr8:142287226 NA -0.54 -7.59 -0.42 5.55e-13 Tonsillectomy; CESC cis rs962856 1.000 rs6739392 chr2:67601971 A/T cg09028215 chr2:67624308 ETAA1 -0.41 -5.42 -0.32 1.33e-7 Pancreatic cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08849330 chr6:166797222 BRP44L -0.47 -6.33 -0.36 1.07e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24183484 chr19:38878553 GGN -0.58 -6.18 -0.35 2.38e-9 Gut microbiome composition (summer); CESC cis rs73206853 0.841 rs57821814 chr12:110829254 A/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.14 0.3 5.33e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9818758 0.607 rs34343820 chr3:49309534 C/G cg00383909 chr3:49044727 WDR6 0.8 6.13 0.35 3.1e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC trans rs1545843 0.565 rs7966752 chr12:84792097 G/T cg03015433 chr16:56623111 MT3 -0.34 -6.12 -0.35 3.37e-9 Major depressive disorder; CESC cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg00149659 chr3:10157352 C3orf10 1.04 11.93 0.59 1.47e-26 Alzheimer's disease; CESC cis rs963731 0.649 rs78421201 chr2:39339424 C/A cg04010122 chr2:39346883 SOS1 0.76 5.65 0.33 4.06e-8 Corticobasal degeneration; CESC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg06808227 chr14:105710500 BRF1 -0.63 -7.51 -0.42 9.08e-13 Mean platelet volume;Platelet distribution width; CESC cis rs7188697 0.922 rs9923491 chr16:58603176 T/G cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg23281280 chr6:28129359 ZNF389 0.6 8.0 0.44 3.86e-14 Depression; CESC cis rs1355223 0.506 rs7130774 chr11:34869267 A/G cg11058730 chr11:34937778 PDHX;APIP -0.56 -6.86 -0.39 4.97e-11 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg00033643 chr7:134001901 SLC35B4 0.4 5.19 0.3 4.14e-7 Mean platelet volume; CESC cis rs2191566 0.576 rs382255 chr19:44494156 T/C cg20607764 chr19:44506953 ZNF230 0.45 5.75 0.33 2.39e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs2425143 1.000 rs45595739 chr20:34320759 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.51 -0.42 9.02e-13 Blood protein levels; CESC cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.1 0.3 6.34e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg14393609 chr7:65229607 NA 0.52 7.12 0.4 1.04e-11 Aortic root size; CESC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg03806693 chr22:41940476 POLR3H -1.14 -13.16 -0.63 8.62e-31 Vitiligo; CESC trans rs3780486 0.846 rs7850878 chr9:33126570 A/G cg20290983 chr6:43655470 MRPS18A 0.98 18.09 0.74 3.45e-48 IgG glycosylation; CESC cis rs35110281 0.681 rs162343 chr21:44957072 A/G cg04455712 chr21:45112962 RRP1B 0.37 5.56 0.32 6.69e-8 Mean corpuscular volume; CESC cis rs1957429 0.614 rs66883381 chr14:65334773 C/T cg23373153 chr14:65346875 NA -0.76 -5.81 -0.34 1.77e-8 Pediatric areal bone mineral density (radius); CESC cis rs919433 0.927 rs13032495 chr2:198189346 C/T cg10820045 chr2:198174542 NA -0.44 -6.42 -0.37 6.16e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs3820928 1.000 rs7579961 chr2:227776976 T/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.81 -0.34 1.74e-8 Pulmonary function; CESC cis rs11645898 0.935 rs4788614 chr16:72188828 C/T cg14768367 chr16:72042858 DHODH 0.58 5.25 0.31 3.15e-7 Blood protein levels; CESC cis rs820218 0.886 rs2165635 chr17:73663296 C/A cg01592526 chr17:73663357 RECQL5;SAP30BP 0.43 5.52 0.32 7.91e-8 Rotator cuff tears; CESC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg17971929 chr21:40555470 PSMG1 1.01 14.68 0.67 4.01e-36 Cognitive function; CESC cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg12386194 chr3:101231763 SENP7 0.49 5.87 0.34 1.27e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9815354 0.812 rs73079360 chr3:41888372 T/A cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.84e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs12541635 0.677 rs7003520 chr8:107061724 G/A cg10147462 chr8:107024639 NA 0.39 5.79 0.34 2e-8 Age of smoking initiation; CESC cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.91e-28 Colonoscopy-negative controls vs population controls; CESC cis rs8028182 0.636 rs4886715 chr15:75831449 C/T cg20655648 chr15:75932815 IMP3 0.48 5.9 0.34 1.08e-8 Sudden cardiac arrest; CESC cis rs2880765 0.835 rs4281668 chr15:86047286 C/T cg19183879 chr15:85880815 NA -0.26 -5.21 -0.3 3.89e-7 Coronary artery disease; CESC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.59 -0.38 2.43e-10 Life satisfaction; CESC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Depression; CESC cis rs61759167 1.000 rs7518255 chr1:3086464 G/A cg01961086 chr1:3086487 PRDM16 -0.34 -5.08 -0.3 7.16e-7 Motion sickness; CESC cis rs861020 1.000 rs630984 chr1:209982293 C/T cg05527609 chr1:210001259 C1orf107 0.96 12.16 0.6 2.57e-27 Orofacial clefts; CESC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg11764359 chr7:65958608 NA -0.72 -10.43 -0.54 1.46e-21 Aortic root size; CESC cis rs921968 0.643 rs523396 chr2:219338789 T/G cg02176678 chr2:219576539 TTLL4 0.42 7.54 0.42 7.49e-13 Mean corpuscular hemoglobin concentration; CESC cis rs73019876 0.901 rs2666448 chr19:22132508 G/A cg11619707 chr19:22235551 ZNF257 -0.27 -5.13 -0.3 5.5e-7 Testicular germ cell tumor; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09324016 chr16:31085582 ZNF668;ZNF646 -0.48 -7.07 -0.4 1.36e-11 Gut microbiota (bacterial taxa); CESC cis rs3806843 1.000 rs2098058 chr5:140157427 A/C cg26395211 chr5:140044315 WDR55 0.44 5.53 0.32 7.82e-8 Depressive symptoms (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27400923 chr3:185826929 ETV5 0.67 7.39 0.41 1.92e-12 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14906687 chr6:157099894 ARID1B 0.47 6.0 0.35 6.46e-9 Gut microbiota (bacterial taxa); CESC cis rs6121246 0.609 rs1009453 chr20:30404840 C/G cg13852791 chr20:30311386 BCL2L1 0.83 10.68 0.55 2.22e-22 Mean corpuscular hemoglobin; CESC cis rs10206020 0.921 rs2280127 chr2:1546531 C/T cg26248373 chr2:1572462 NA -0.59 -6.84 -0.39 5.44e-11 IgG glycosylation; CESC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs4481887 0.861 rs4497248 chr1:248450525 T/C cg00666640 chr1:248458726 OR2T12 0.38 6.29 0.36 1.27e-9 Common traits (Other); CESC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.1e-18 Prudent dietary pattern; CESC cis rs11190604 1.000 rs10786598 chr10:102291579 G/A cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs754466 0.606 rs11002308 chr10:79594796 A/T cg17075019 chr10:79541650 NA -0.87 -13.7 -0.64 1.2e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2204008 0.837 rs11169157 chr12:37980047 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.75 0.33 2.48e-8 Bladder cancer; CESC cis rs9389248 0.708 rs7750574 chr6:135350932 G/C cg22676075 chr6:135203613 NA 0.53 7.15 0.4 8.36e-12 High light scatter reticulocyte percentage of red cells; CESC cis rs11025559 0.812 rs10833338 chr11:20514709 A/G cg19653624 chr11:20408972 PRMT3 -0.45 -5.2 -0.3 4.02e-7 Pursuit maintenance gain; CESC cis rs722599 0.748 rs2300599 chr14:75359441 A/G cg08847533 chr14:75593920 NEK9 -0.46 -5.54 -0.32 7.45e-8 IgG glycosylation; CESC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg03526776 chr6:41159608 TREML2 0.32 5.94 0.34 9.15e-9 Alzheimer's disease (late onset); CESC cis rs1707322 0.721 rs10890344 chr1:46166090 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs709400 0.628 rs3783394 chr14:103858673 G/A cg12935359 chr14:103987150 CKB -0.52 -7.62 -0.42 4.4e-13 Body mass index; CESC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.91 0.44 6.82e-14 Electroencephalogram traits; CESC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg14773178 chr5:1868261 NA 0.32 5.77 0.33 2.18e-8 Cardiovascular disease risk factors; CESC cis rs4900538 0.928 rs1190551 chr14:102911508 A/G cg18135206 chr14:102964638 TECPR2 -0.8 -10.78 -0.55 1.03e-22 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs123509 0.913 rs339685 chr3:42782952 C/G cg22035501 chr5:112073398 APC 0.56 6.0 0.35 6.42e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2777491 0.915 rs7178634 chr15:41634587 A/G cg20272979 chr15:41787780 ITPKA 0.36 5.33 0.31 2.09e-7 Ulcerative colitis; CESC cis rs11642862 1.000 rs75500538 chr16:30782449 G/A cg02466173 chr16:30829666 NA -0.6 -6.08 -0.35 4.15e-9 Tonsillectomy; CESC cis rs6687430 0.562 rs6676491 chr1:10633421 A/C cg07384165 chr1:10488281 NA -0.45 -6.27 -0.36 1.49e-9 Hand grip strength; CESC cis rs6088590 1.000 rs6120747 chr20:33449769 T/C cg08999081 chr20:33150536 PIGU 0.6 9.03 0.48 3.75e-17 Coronary artery disease; CESC cis rs7267979 0.966 rs2261720 chr20:25260641 T/G cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs6665290 0.669 rs3795446 chr1:227180981 C/T cg10327440 chr1:227177885 CDC42BPA 1.11 24.6 0.83 2.18e-70 Myeloid white cell count; CESC cis rs25645 0.792 rs8077456 chr17:38128765 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.5 7.09 0.4 1.24e-11 Myeloid white cell count; CESC cis rs763014 0.931 rs2071981 chr16:630025 C/G cg09263875 chr16:632152 PIGQ 0.67 11.14 0.56 6.6e-24 Height; CESC cis rs77106637 0.860 rs11603334 chr11:72432985 G/A cg04827223 chr11:72435913 ARAP1 -0.62 -6.53 -0.37 3.25e-10 Type 2 diabetes; CESC cis rs6977660 0.507 rs72591448 chr7:19775298 C/T cg07541023 chr7:19748670 TWISTNB 0.81 7.44 0.42 1.42e-12 Thyroid stimulating hormone; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13671121 chr17:36908172 PSMB3 -0.44 -6.19 -0.36 2.29e-9 Gambling; CESC cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg02564969 chr6:151773285 C6orf211;RMND1 -0.67 -8.97 -0.48 5.59e-17 Menarche (age at onset); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02551244 chr2:23608357 KLHL29 0.5 6.9 0.39 3.84e-11 Systemic lupus erythematosus; CESC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg08470875 chr2:26401718 FAM59B -0.75 -7.79 -0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg25767906 chr1:53392781 SCP2 -0.54 -7.5 -0.42 9.4e-13 Monocyte count; CESC cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -7.68 -0.43 3.12e-13 Personality dimensions; CESC cis rs6570726 0.967 rs9403706 chr6:145795187 C/T cg05347473 chr6:146136440 FBXO30 -0.42 -5.63 -0.33 4.68e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs738322 0.870 rs2277844 chr22:38577515 G/A cg17652424 chr22:38574118 PLA2G6 0.31 5.34 0.31 2.01e-7 Cutaneous nevi; CESC cis rs6061231 0.631 rs2427317 chr20:60975725 C/T cg23531748 chr20:60969906 CABLES2 0.39 5.41 0.32 1.41e-7 Colorectal cancer; CESC cis rs9837602 1.000 rs10049383 chr3:99748548 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 7.45 0.42 1.36e-12 Breast cancer; CESC cis rs727505 1.000 rs28392553 chr7:124442944 C/T cg23710748 chr7:124431027 NA -0.38 -6.06 -0.35 4.77e-9 Lewy body disease; CESC cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg03467027 chr4:99064603 C4orf37 0.46 5.82 0.34 1.73e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg04944784 chr2:26401820 FAM59B -0.66 -7.5 -0.42 9.54e-13 Gut microbiome composition (summer); CESC cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg11752832 chr7:134001865 SLC35B4 0.53 6.86 0.39 4.93e-11 Mean platelet volume; CESC cis rs17826219 0.706 rs8071236 chr17:29100002 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Body mass index; CESC cis rs4728302 0.869 rs7792905 chr7:133595602 G/T cg10665199 chr7:133106180 EXOC4 0.39 5.51 0.32 8.43e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7296418 0.636 rs11057261 chr12:123797567 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.33 -5.29 -0.31 2.57e-7 Platelet count; CESC cis rs4481887 1.000 rs11204626 chr1:248458974 T/A cg00666640 chr1:248458726 OR2T12 0.39 6.5 0.37 3.86e-10 Common traits (Other); CESC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.68 0.58 1.07e-25 Platelet count; CESC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg00933542 chr6:150070202 PCMT1 0.29 5.11 0.3 6.09e-7 Lung cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00171436 chr12:122985592 ZCCHC8 -0.44 -6.32 -0.36 1.09e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11853189 0.882 rs78827644 chr15:78556250 G/A cg22935921 chr15:78556834 DNAJA4 0.61 5.1 0.3 6.35e-7 Red cell distribution width; CESC cis rs55871839 0.684 rs13271523 chr8:59806664 T/C cg07426533 chr8:59803705 TOX -0.49 -7.08 -0.4 1.32e-11 Pneumonia; CESC trans rs9792269 0.735 rs12541389 chr8:129243389 C/T cg07707498 chr16:46865555 C16orf87 -0.57 -6.04 -0.35 5.08e-9 Celiac disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15824864 chr17:77812175 CBX4 -0.53 -6.18 -0.35 2.38e-9 Gut microbiome composition (summer); CESC cis rs6088580 0.634 rs6059896 chr20:33111783 T/C cg08999081 chr20:33150536 PIGU 0.65 11.45 0.58 6.19e-25 Glomerular filtration rate (creatinine); CESC cis rs2072732 0.861 rs67919793 chr1:2954230 T/C cg15211996 chr1:2936768 ACTRT2 0.34 6.04 0.35 5.27e-9 Plateletcrit; CESC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg20203395 chr5:56204925 C5orf35 -0.42 -5.08 -0.3 7.06e-7 Initial pursuit acceleration; CESC cis rs36051895 0.553 rs16922773 chr9:5197436 T/G cg02405213 chr9:5042618 JAK2 -0.57 -6.37 -0.36 8.28e-10 Pediatric autoimmune diseases; CESC cis rs1577917 0.958 rs34765423 chr6:86484448 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.5 -6.7 -0.38 1.28e-10 Response to antipsychotic treatment; CESC cis rs11711311 0.736 rs13320940 chr3:113400954 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 6.56 0.37 2.87e-10 IgG glycosylation; CESC cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg16339924 chr4:17578868 LAP3 -0.54 -6.8 -0.39 6.74e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs55871839 0.559 rs66954327 chr8:59825133 A/G cg07426533 chr8:59803705 TOX 0.39 5.23 0.31 3.43e-7 Pneumonia; CESC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg14558114 chr2:88469736 THNSL2 0.59 5.56 0.32 6.52e-8 Plasma clusterin levels; CESC cis rs67478160 0.655 rs4900598 chr14:104281541 T/C cg08213375 chr14:104286397 PPP1R13B 0.54 10.69 0.55 2.07e-22 Schizophrenia; CESC cis rs3096299 0.838 rs4785561 chr16:89429052 C/T cg08822215 chr16:89438651 ANKRD11 -0.35 -5.09 -0.3 6.72e-7 Multiple myeloma (IgH translocation); CESC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg18904891 chr8:8559673 CLDN23 0.7 8.35 0.46 3.92e-15 Obesity-related traits; CESC cis rs4975709 1.000 rs4975709 chr5:1877280 A/C cg17650747 chr5:1873721 NA 0.38 5.17 0.3 4.56e-7 Cardiovascular disease risk factors; CESC cis rs17655565 1.000 rs17126647 chr12:52706194 C/T cg08257133 chr12:52711352 KRT83 0.51 6.28 0.36 1.37e-9 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg11494091 chr17:61959527 GH2 0.75 12.76 0.62 2.11e-29 Prudent dietary pattern; CESC cis rs1670533 1.000 rs11735663 chr4:1051845 C/T cg04106633 chr4:1044584 NA 0.41 5.14 0.3 5.46e-7 Recombination rate (females); CESC trans rs498872 0.507 rs10892247 chr11:118490076 G/A cg24645679 chr7:2611236 IQCE -0.51 -6.07 -0.35 4.31e-9 Glioma; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg03321319 chr22:22222323 MAPK1 -0.46 -6.05 -0.35 5.04e-9 Recombination measurement; CESC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg22143856 chr6:28129313 ZNF389 0.45 5.66 0.33 3.95e-8 Depression; CESC cis rs708547 0.874 rs7674167 chr4:57721477 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.53 -5.91 -0.34 1.05e-8 Response to bleomycin (chromatid breaks); CESC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg05368731 chr17:41323189 NBR1 0.78 10.79 0.55 9.37e-23 Menopause (age at onset); CESC cis rs6087990 1.000 rs2018002 chr20:31351623 A/T cg13636640 chr20:31349939 DNMT3B 0.94 16.99 0.72 2.74e-44 Ulcerative colitis; CESC cis rs7772486 0.790 rs2253768 chr6:146199922 A/G cg23711669 chr6:146136114 FBXO30 1.02 15.48 0.69 5.93e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs1728785 1.000 rs1170431 chr16:68605639 T/C cg02972257 chr16:68554789 NA -0.59 -6.71 -0.38 1.2e-10 Ulcerative colitis; CESC trans rs1814175 0.616 rs847641 chr11:49919261 T/C cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs1348850 0.914 rs6761593 chr2:178451600 A/G cg23306229 chr2:178417860 TTC30B -0.47 -5.95 -0.34 8.32e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg22541963 chr20:60982533 CABLES2 -0.52 -6.55 -0.37 2.9e-10 Colorectal cancer; CESC cis rs7927592 0.871 rs871212 chr11:68348695 T/A cg20283391 chr11:68216788 NA -0.5 -6.01 -0.35 6.01e-9 Total body bone mineral density; CESC trans rs2415984 0.846 rs7156814 chr14:46854097 C/A cg14945696 chr3:52713679 PBRM1 -0.39 -6.05 -0.35 4.98e-9 Number of children ever born; CESC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 5.02e-9 Prudent dietary pattern; CESC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.75 10.28 0.53 4.53e-21 Prudent dietary pattern; CESC trans rs60380162 0.928 rs60507195 chr1:87727014 G/A cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.03 -0.35 5.48e-9 Loneliness (linear analysis); CESC cis rs7078219 0.505 rs4129133 chr10:101284570 T/C cg09788492 chr10:101292477 NKX2-3 0.33 6.35 0.36 9.54e-10 Dental caries; CESC trans rs7618501 0.633 rs9853222 chr3:50022926 T/C cg21659725 chr3:3221576 CRBN 0.53 7.37 0.41 2.19e-12 Intelligence (multi-trait analysis); CESC cis rs7772486 0.875 rs2474353 chr6:146323883 G/A cg23711669 chr6:146136114 FBXO30 0.85 12.2 0.6 1.88e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs9325144 0.555 rs11183215 chr12:38693127 G/A cg23762105 chr12:34175262 ALG10 0.49 6.45 0.37 5.43e-10 Morning vs. evening chronotype; CESC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg02187348 chr16:89574699 SPG7 0.66 9.15 0.49 1.56e-17 Multiple myeloma (IgH translocation); CESC cis rs17407555 0.821 rs4533775 chr4:10141404 G/C cg00071950 chr4:10020882 SLC2A9 -0.58 -5.29 -0.31 2.53e-7 Schizophrenia (age at onset); CESC cis rs1976403 0.510 rs1697421 chr1:21823292 C/T cg21906605 chr1:21766650 NBPF3 0.41 5.38 0.31 1.61e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg00684032 chr4:1343700 KIAA1530 0.41 5.72 0.33 2.95e-8 Obesity-related traits; CESC cis rs2228479 0.850 rs17233455 chr16:89816407 A/G cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC trans rs561341 0.769 rs7217004 chr17:30178092 A/G cg27661571 chr11:113659931 NA 0.66 6.04 0.35 5.3300000000000004e-09 Hip circumference adjusted for BMI; CESC cis rs2816062 0.747 rs2816049 chr1:18893768 A/G cg18795169 chr1:18902165 NA -0.95 -19.06 -0.76 1.32e-51 Urate levels in lean individuals; CESC cis rs6662572 1.000 rs41310432 chr1:46083706 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 5.63 0.33 4.52e-8 Blood protein levels; CESC cis rs1185460 1.000 rs15818 chr11:118952173 A/G cg23280166 chr11:118938394 VPS11 0.42 5.48 0.32 9.76e-8 Coronary artery disease; CESC cis rs6582630 0.519 rs4405392 chr12:38293661 A/C cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.23e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs7917772 0.503 rs7093285 chr10:104374815 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.33 0.41 2.77e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs250677 0.652 rs36042 chr5:148439782 G/T cg18129178 chr5:148520854 ABLIM3 -0.6 -6.13 -0.35 3.23e-9 Breast cancer; CESC cis rs2124969 0.527 rs72982044 chr2:161049395 G/A cg03641300 chr2:160917029 PLA2R1 -0.58 -5.98 -0.35 7.01e-9 Waist circumference adjusted for body mass index; CESC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg09323728 chr8:95962352 TP53INP1 -0.4 -8.78 -0.47 2.13e-16 Type 2 diabetes; CESC cis rs2180341 0.960 rs6913424 chr6:127707010 A/C cg24812749 chr6:127587940 RNF146 1.03 14.68 0.67 4.05e-36 Breast cancer; CESC cis rs7208859 0.623 rs1054397 chr17:29110196 T/C cg13385521 chr17:29058706 SUZ12P 0.8 6.45 0.37 5.29e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs854765 0.693 rs12941039 chr17:17765655 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.48 -6.71 -0.38 1.18e-10 Total body bone mineral density; CESC cis rs7116495 0.609 rs6592457 chr11:71738086 G/C cg26138937 chr11:71823887 C11orf51 -1.33 -7.85 -0.43 1.06e-13 Severe influenza A (H1N1) infection; CESC cis rs561341 1.000 rs483301 chr17:30293398 G/T cg12193833 chr17:30244370 NA -0.76 -6.94 -0.39 2.92e-11 Hip circumference adjusted for BMI; CESC trans rs35851103 0.600 rs4841662 chr8:11843758 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.01 -0.35 6.16e-9 Neuroticism; CESC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg24250549 chr1:154909240 PMVK 0.75 11.2 0.57 4.32e-24 Prostate cancer; CESC trans rs1814175 0.817 rs2866863 chr11:49953242 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -20.41 -0.78 2.75e-56 Height; CESC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg11644478 chr21:40555479 PSMG1 -0.57 -7.88 -0.44 8.72e-14 Menarche (age at onset); CESC cis rs703842 0.560 rs11533604 chr12:58047713 G/A cg18357645 chr12:58087776 OS9 -0.54 -7.04 -0.4 1.65e-11 Multiple sclerosis; CESC cis rs13385 0.813 rs6859064 chr5:139663301 A/T cg26211634 chr5:139558579 C5orf32 0.47 5.09 0.3 6.77e-7 Atrial fibrillation; CESC cis rs4889855 0.505 rs8076974 chr17:78621817 G/A cg16591659 chr17:78472290 NA -0.32 -5.22 -0.31 3.68e-7 Fractional excretion of uric acid; CESC trans rs9296661 1.000 rs1326589 chr6:51674161 A/G cg18455653 chr20:17662865 RRBP1 0.46 6.11 0.35 3.47e-9 Weight loss (gastric bypass surgery); CESC trans rs11098499 0.909 rs2127821 chr4:120394535 T/C cg25214090 chr10:38739885 LOC399744 0.71 10.36 0.54 2.41e-21 Corneal astigmatism; CESC cis rs3857067 0.509 rs61069704 chr4:95091856 C/T cg11021082 chr4:95130006 SMARCAD1 -0.47 -6.28 -0.36 1.39e-9 QT interval; CESC cis rs712039 0.652 rs853227 chr17:35797529 C/T cg16670864 chr17:35848621 DUSP14 0.41 5.07 0.3 7.41e-7 Tuberculosis; CESC cis rs11864453 0.611 rs9926927 chr16:72130556 G/T cg16558253 chr16:72132732 DHX38 -0.54 -8.44 -0.46 2.03e-15 Fibrinogen levels; CESC cis rs9811920 0.809 rs4928150 chr3:99685991 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 7.66 0.43 3.51e-13 Axial length; CESC cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg02725872 chr8:58115012 NA -0.37 -5.86 -0.34 1.39e-8 Developmental language disorder (linguistic errors); CESC cis rs7296418 0.699 rs11608297 chr12:123826642 T/C cg00376283 chr12:123451042 ABCB9 0.56 7.64 0.42 3.92e-13 Platelet count; CESC cis rs2742234 0.541 rs11528481 chr10:43737767 C/A cg07801480 chr10:43725741 RASGEF1A -0.4 -5.13 -0.3 5.71e-7 Hirschsprung disease; CESC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg10150615 chr22:24372951 LOC391322 -0.55 -7.14 -0.4 8.73e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6502050 0.835 rs4789724 chr17:80150546 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.25 -0.31 3.18e-7 Life satisfaction; CESC cis rs4253772 0.550 rs9615913 chr22:46668515 A/T cg24881330 chr22:46731750 TRMU -0.86 -9.8 -0.52 1.46e-19 LDL cholesterol;Cholesterol, total; CESC cis rs2439831 0.867 rs935901 chr15:43651256 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.73 5.75 0.33 2.39e-8 Lung cancer in ever smokers; CESC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg27478167 chr7:817139 HEATR2 -0.47 -5.05 -0.3 8.35e-7 Cerebrospinal P-tau181p levels; CESC cis rs7267979 0.744 rs6050464 chr20:25209299 C/A cg08601574 chr20:25228251 PYGB 0.44 6.33 0.36 1.05e-9 Liver enzyme levels (alkaline phosphatase); CESC cis rs2180341 1.000 rs2180341 chr6:127600630 C/T cg27446573 chr6:127587934 RNF146 1.07 15.79 0.7 4.78e-40 Breast cancer; CESC cis rs12368653 0.651 rs2277326 chr12:58202419 A/C cg00677455 chr12:58241039 CTDSP2 0.48 6.02 0.35 5.8e-9 Multiple sclerosis; CESC cis rs3008870 1.000 rs3008856 chr1:67387901 T/C cg02640540 chr1:67518911 SLC35D1 0.48 5.2 0.3 3.97e-7 Lymphocyte percentage of white cells; CESC cis rs897080 0.552 rs698799 chr2:44690618 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.55 0.32 7.09e-8 Height; CESC cis rs870825 0.616 rs1401361 chr4:185643742 G/C cg04058563 chr4:185651563 MLF1IP 0.64 7.13 0.4 9.4e-12 Blood protein levels; CESC cis rs13082711 0.554 rs13087873 chr3:27392326 C/T cg02860705 chr3:27208620 NA 0.73 8.23 0.45 8.65e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs6088590 1.000 rs55753039 chr20:33394940 C/T cg24642439 chr20:33292090 TP53INP2 0.84 11.3 0.57 2e-24 Coronary artery disease; CESC cis rs7590720 1.000 rs934156 chr2:216901482 C/T cg12620499 chr2:216877984 MREG -0.84 -11.47 -0.58 5.37e-25 Alcohol dependence; CESC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg18402987 chr7:1209562 NA 0.76 7.61 0.42 4.74e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -6.83 -0.39 5.77e-11 Bipolar disorder and schizophrenia; CESC cis rs3749237 0.964 rs2352967 chr3:49871641 C/T cg02487422 chr3:49467188 NICN1 0.43 5.05 0.3 8.09e-7 Resting heart rate; CESC cis rs6815814 0.731 rs10776482 chr4:38774785 A/G cg02016764 chr4:38805732 TLR1 -0.44 -6.08 -0.35 4.24e-9 Breast cancer; CESC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg16325326 chr1:53192061 ZYG11B 0.81 12.89 0.62 7.72e-30 Monocyte count; CESC cis rs6991838 0.550 rs7817112 chr8:66537120 C/A cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs1003719 0.715 rs1981432 chr21:38541356 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.02 -0.44 3.39e-14 Eye color traits; CESC cis rs11249608 0.548 rs2132672 chr5:178457742 A/C cg01312482 chr5:178451176 ZNF879 -0.44 -5.88 -0.34 1.22e-8 Pubertal anthropometrics; CESC cis rs854765 0.619 rs1101727 chr17:18016148 T/C cg16928487 chr17:17741425 SREBF1 -0.51 -8.07 -0.44 2.42e-14 Total body bone mineral density; CESC cis rs4919087 0.590 rs61569149 chr10:99073879 A/G cg25902810 chr10:99078978 FRAT1 -0.5 -5.65 -0.33 4.22e-8 Monocyte count; CESC cis rs477692 1.000 rs577227 chr10:131404528 C/T cg05714579 chr10:131428358 MGMT 0.49 6.7 0.38 1.24e-10 Response to temozolomide; CESC cis rs854765 0.551 rs6502626 chr17:17849450 C/T cg04398451 chr17:18023971 MYO15A -0.73 -10.65 -0.55 2.87e-22 Total body bone mineral density; CESC cis rs6460942 0.597 rs6968664 chr7:12515493 T/C cg06484146 chr7:12443880 VWDE -0.64 -7.13 -0.4 9.4e-12 Coronary artery disease; CESC cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg20307385 chr11:47447363 PSMC3 -0.6 -7.31 -0.41 3.23e-12 Subjective well-being; CESC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg15813090 chr5:442598 EXOC3;C5orf55 0.41 6.2 0.36 2.17e-9 Cystic fibrosis severity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15479073 chr15:59499039 LDHAL6B;MYO1E 0.46 6.19 0.36 2.24e-9 Fibrinogen levels; CESC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg11764359 chr7:65958608 NA -0.54 -7.05 -0.4 1.59e-11 Aortic root size; CESC cis rs4253772 0.530 rs79354880 chr22:46746419 C/A cg10541313 chr22:46663664 TTC38 0.74 5.15 0.3 4.99e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6964587 0.626 rs4729011 chr7:91515419 G/A cg17063962 chr7:91808500 NA -0.46 -6.54 -0.37 3.22e-10 Breast cancer; CESC trans rs1728785 1.000 rs7205960 chr16:68565604 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs1801251 0.778 rs778340 chr2:233734083 C/T cg08000102 chr2:233561755 GIGYF2 -0.59 -7.94 -0.44 5.66e-14 Coronary artery disease; CESC trans rs9467711 0.606 rs9379899 chr6:26603015 T/A cg06606381 chr12:133084897 FBRSL1 -0.78 -7.41 -0.41 1.7e-12 Autism spectrum disorder or schizophrenia; CESC cis rs9847710 0.566 rs2564951 chr3:53060449 C/T cg18337363 chr3:52569053 NT5DC2 -0.31 -5.09 -0.3 6.94e-7 Ulcerative colitis; CESC cis rs7656342 0.686 rs1464258 chr4:9834107 A/C cg00071950 chr4:10020882 SLC2A9 -0.37 -5.18 -0.3 4.36e-7 Gut microbiota (bacterial taxa); CESC cis rs3820928 0.904 rs2396432 chr2:227765891 C/T cg05526886 chr2:227700861 RHBDD1 -0.44 -5.65 -0.33 4.24e-8 Pulmonary function; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg10283690 chr1:245027135 HNRNPU -0.48 -6.32 -0.36 1.09e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg19077165 chr18:44547161 KATNAL2 -0.58 -8.68 -0.47 4e-16 Personality dimensions; CESC cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -7.41 -0.41 1.71e-12 Personality dimensions; CESC cis rs9291683 0.585 rs12648479 chr4:10104571 G/A cg00071950 chr4:10020882 SLC2A9 -0.59 -9.38 -0.5 3.1e-18 Bone mineral density; CESC cis rs644799 1.000 rs12786522 chr11:95522858 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.69 0.67 3.96e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2439831 0.681 rs7175434 chr15:43628542 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.99 0.56 2.1e-23 Lung cancer in ever smokers; CESC cis rs4906332 1.000 rs4900574 chr14:103879024 G/A cg09975044 chr14:104007538 NA -0.38 -5.28 -0.31 2.68e-7 Coronary artery disease; CESC cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg22764044 chr5:178986830 RUFY1 0.38 5.33 0.31 2.13e-7 Lung cancer; CESC cis rs11785693 0.862 rs17435835 chr8:5000713 C/T cg26367366 chr8:4980734 NA -0.78 -7.36 -0.41 2.27e-12 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs79349575 0.811 rs12601072 chr17:46997998 T/C cg26022315 chr17:47021804 SNF8 0.39 5.18 0.3 4.5e-7 Type 2 diabetes; CESC cis rs7762018 1.000 rs7746598 chr6:170084933 T/A cg13891659 chr6:170190454 C6orf122;C6orf208 0.53 5.52 0.32 8.28e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs10905065 0.965 rs12571639 chr10:5748052 G/A cg11519256 chr10:5708881 ASB13 0.44 5.89 0.34 1.17e-8 Menopause (age at onset); CESC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg20573242 chr4:122745356 CCNA2 0.62 7.44 0.42 1.41e-12 Type 2 diabetes; CESC cis rs8180040 0.726 rs2385867 chr3:47059323 C/T cg27129171 chr3:47204927 SETD2 0.72 11.05 0.56 1.38e-23 Colorectal cancer; CESC cis rs7605827 0.897 rs1468912 chr2:15662922 A/G cg19274914 chr2:15703543 NA 0.36 6.38 0.36 8.02e-10 Educational attainment (years of education); CESC cis rs7524258 0.867 rs916392 chr1:7271930 T/C cg07173049 chr1:7289937 CAMTA1 0.44 6.52 0.37 3.46e-10 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs2573652 0.722 rs12914180 chr15:100544416 T/C cg09918751 chr15:100517450 ADAMTS17 -0.31 -5.76 -0.33 2.39e-8 Height; CESC cis rs12368653 0.666 rs1050045 chr12:58115271 A/G cg18357645 chr12:58087776 OS9 0.43 6.6 0.38 2.21e-10 Multiple sclerosis; CESC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg24549020 chr5:56110836 MAP3K1 0.66 7.4 0.41 1.77e-12 Initial pursuit acceleration; CESC cis rs2228479 0.702 rs12600047 chr16:89831630 G/A cg06558623 chr16:89946397 TCF25 1.15 8.92 0.48 8.06e-17 Skin colour saturation; CESC cis rs6964587 1.000 rs11772102 chr7:91558326 A/T cg17063962 chr7:91808500 NA -0.58 -7.81 -0.43 1.34e-13 Breast cancer; CESC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg04287289 chr16:89883240 FANCA 0.93 16.69 0.72 3.23e-43 Vitiligo; CESC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg25036284 chr2:26402008 FAM59B -0.8 -8.57 -0.47 8.7e-16 Gut microbiome composition (summer); CESC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg25985355 chr7:65971099 NA 0.32 5.26 0.31 2.95e-7 Aortic root size; CESC cis rs1707322 1.000 rs785510 chr1:46528618 T/C cg06784218 chr1:46089804 CCDC17 -0.36 -5.86 -0.34 1.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11234017 chr17:42767172 CCDC43 0.45 6.04 0.35 5.17e-9 Gut microbiota (bacterial taxa); CESC cis rs3540 0.618 rs11609 chr15:91043765 C/G cg10434728 chr15:90938212 IQGAP1 -0.41 -7.27 -0.41 3.94e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10999410 chr5:14487610 TRIO -0.6 -6.98 -0.39 2.31e-11 Gut microbiome composition (summer); CESC cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg01181863 chr3:195395398 SDHAP2 -0.48 -5.71 -0.33 3.03e-8 Pancreatic cancer; CESC cis rs7555523 0.830 rs12691500 chr1:165687761 A/G cg24409356 chr1:165738333 TMCO1 0.73 6.67 0.38 1.5e-10 Intraocular pressure;Glaucoma (high intraocular pressure); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01084379 chr5:179160712 MAML1 0.64 7.69 0.43 2.96e-13 Gut microbiome composition (summer); CESC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg11366901 chr6:160182831 ACAT2 0.76 9.37 0.5 3.35e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs7833986 0.501 rs2719245 chr8:56894359 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.16 0.4 8.04e-12 Height; CESC cis rs1801251 0.963 rs35395584 chr2:233573698 G/C cg25237894 chr2:233734115 C2orf82 0.5 8.43 0.46 2.24e-15 Coronary artery disease; CESC cis rs10751667 0.643 rs11246362 chr11:969818 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.29 -0.31 2.51e-7 Alzheimer's disease (late onset); CESC cis rs1775715 0.835 rs12266771 chr10:32231380 G/A cg18675610 chr10:32216311 ARHGAP12 0.35 5.35 0.31 1.87e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4595586 0.545 rs7310463 chr12:39368927 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs6951245 0.542 rs28460147 chr7:1217192 G/A cg23708337 chr7:1209742 NA 0.52 5.52 0.32 8.27e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg18099408 chr3:52552593 STAB1 -0.34 -5.44 -0.32 1.2e-7 Bipolar disorder; CESC cis rs11997175 0.846 rs11776207 chr8:33765126 G/T ch.8.33884649F chr8:33765107 NA -0.67 -8.37 -0.46 3.4e-15 Body mass index; CESC cis rs193541 0.632 rs154512 chr5:122195040 T/C cg19412675 chr5:122181750 SNX24 0.47 5.58 0.32 5.95e-8 Glucose homeostasis traits; CESC cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.75 -10.83 -0.55 7.34e-23 Platelet count; CESC cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg16339924 chr4:17578868 LAP3 0.73 9.53 0.51 1.03e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11098499 0.863 rs3736115 chr4:120488703 A/G cg09307838 chr4:120376055 NA -0.85 -10.87 -0.56 5.46e-23 Corneal astigmatism; CESC cis rs765787 0.530 rs2668751 chr15:45517293 T/C cg24006582 chr15:45444508 DUOX1 -0.58 -7.07 -0.4 1.4e-11 Uric acid levels; CESC cis rs1348850 0.651 rs4893936 chr2:178240676 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.65 8.92 0.48 7.66e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg07507251 chr3:52567010 NT5DC2 0.32 5.41 0.32 1.42e-7 Bipolar disorder; CESC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.75 0.43 1.94e-13 Prudent dietary pattern; CESC trans rs11098499 0.954 rs9685777 chr4:120365965 C/A cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs6691722 0.506 rs11587667 chr1:24715435 C/G cg18323236 chr1:24743029 NIPAL3 0.5 7.62 0.42 4.41e-13 Response to interferon beta in multiple sclerosis; CESC cis rs72945132 0.522 rs4367974 chr11:70248900 C/T cg00319359 chr11:70116639 PPFIA1 0.61 6.64 0.38 1.77e-10 Coronary artery disease; CESC cis rs9303280 0.743 rs12946510 chr17:37912377 C/T cg20243544 chr17:37824526 PNMT 0.52 6.95 0.39 2.83e-11 Self-reported allergy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15192242 chr7:102279588 UPLP;POLR2J2 -0.68 -8.15 -0.45 1.47e-14 Gut microbiome composition (summer); CESC trans rs877282 0.735 rs111609055 chr10:826539 A/G cg22713356 chr15:30763199 NA 0.95 9.12 0.49 1.99e-17 Uric acid levels; CESC cis rs4820294 1.000 rs739139 chr22:38067011 C/G cg21798802 chr22:38057573 PDXP 0.46 7.99 0.44 4.16e-14 Fat distribution (HIV); CESC cis rs12681366 0.734 rs2046664 chr8:95387941 G/A cg13257157 chr8:95487014 RAD54B 0.39 5.24 0.31 3.34e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs2425143 1.000 rs2425141 chr20:34350123 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.72 6.81 0.39 6.58e-11 Blood protein levels; CESC cis rs1062177 0.826 rs2915879 chr5:151147442 A/G cg00977110 chr5:151150581 G3BP1 0.61 6.71 0.38 1.17e-10 Preschool internalizing problems; CESC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg10596483 chr8:143751796 JRK 0.44 5.36 0.31 1.8e-7 Urinary tract infection frequency; CESC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg13206674 chr6:150067644 NUP43 0.39 5.53 0.32 7.66e-8 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25350635 chr12:49182847 ADCY6 0.53 6.0 0.35 6.56e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.754 rs6922507 chr6:146250155 A/T cg23711669 chr6:146136114 FBXO30 -0.94 -13.66 -0.64 1.66e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg04315214 chr1:2043799 PRKCZ -0.41 -6.69 -0.38 1.34e-10 Height; CESC cis rs1483890 0.723 rs34184121 chr3:69411426 A/T cg22125112 chr3:69402811 FRMD4B 0.39 5.24 0.31 3.3e-7 Resting heart rate; CESC cis rs11792861 0.962 rs3750452 chr9:111801353 T/C cg05043794 chr9:111880884 C9orf5 -0.41 -6.87 -0.39 4.47e-11 Menarche (age at onset); CESC cis rs6424115 0.830 rs6663474 chr1:24199642 G/A cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03469472 chr1:173991446 NA 0.47 6.21 0.36 2.07e-9 Gut microbiota (bacterial taxa); CESC cis rs2730245 1.000 rs2730241 chr7:158723014 T/C cg15303052 chr7:158526867 ESYT2 0.43 5.16 0.3 4.93e-7 Height; CESC cis rs4253772 0.591 rs9627324 chr22:46656511 A/G cg24881330 chr22:46731750 TRMU 0.89 9.99 0.52 3.68e-20 LDL cholesterol;Cholesterol, total; CESC cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg15541040 chr2:3486749 NA -0.45 -5.6 -0.33 5.33e-8 Neurofibrillary tangles; CESC cis rs6088580 0.524 rs6088568 chr20:33265971 A/C cg24642439 chr20:33292090 TP53INP2 -0.47 -5.48 -0.32 9.79e-8 Glomerular filtration rate (creatinine); CESC cis rs9303280 0.773 rs4795397 chr17:38023745 A/G cg20243544 chr17:37824526 PNMT 0.52 6.91 0.39 3.61e-11 Self-reported allergy; CESC cis rs2731664 0.740 rs2731670 chr5:176848019 G/T cg23176889 chr5:176863531 GRK6 0.56 9.52 0.5 1.12e-18 Intelligence (multi-trait analysis); CESC trans rs4942242 0.663 rs34978818 chr13:44214096 T/C cg19169023 chr15:41853346 TYRO3 -0.59 -7.71 -0.43 2.52e-13 Response to tocilizumab in rheumatoid arthritis; CESC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.8e-9 Prudent dietary pattern; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08448040 chr3:13521693 HDAC11 -0.45 -6.39 -0.37 7.57e-10 Gambling; CESC cis rs4660261 0.526 rs2485997 chr1:44345841 G/C cg12908607 chr1:44402522 ARTN -0.43 -6.2 -0.36 2.12e-9 Intelligence (multi-trait analysis); CESC trans rs2997457 0.527 rs2997451 chr1:26369297 T/C cg08109345 chr1:204226218 PLEKHA6 -0.59 -6.09 -0.35 3.91e-9 Facial morphology (factor 16); CESC cis rs3126085 0.935 rs6666382 chr1:152217226 C/G cg26876637 chr1:152193138 HRNR -0.45 -5.11 -0.3 6.14e-7 Atopic dermatitis; CESC cis rs6754311 0.731 rs7579771 chr2:136580260 T/A cg15123519 chr2:136567270 LCT -0.33 -5.63 -0.33 4.57e-8 Mosquito bite size; CESC cis rs77741769 0.529 rs909053 chr12:121237668 G/A cg02419362 chr12:121203948 SPPL3 0.34 5.51 0.32 8.52e-8 Mean corpuscular volume; CESC cis rs559928 0.606 rs55970968 chr11:63961433 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.82 0.34 1.7e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs712039 0.687 rs11656455 chr17:35771885 G/A cg16670864 chr17:35848621 DUSP14 0.44 5.5 0.32 8.74e-8 Tuberculosis; CESC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg05234568 chr11:5960015 NA 0.73 10.56 0.54 5.64e-22 DNA methylation (variation); CESC cis rs72945132 0.678 rs35733235 chr11:70235595 C/T cg00319359 chr11:70116639 PPFIA1 0.71 6.66 0.38 1.6e-10 Coronary artery disease; CESC cis rs4594175 0.926 rs11157803 chr14:51627700 C/T cg23942311 chr14:51606299 NA 0.39 5.93 0.34 9.29e-9 Cancer; CESC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg22143856 chr6:28129313 ZNF389 0.53 6.71 0.38 1.2e-10 Depression; CESC cis rs2040771 0.740 rs9605960 chr22:19214636 G/C cg02655711 chr22:19163373 SLC25A1 0.41 5.97 0.34 7.41e-9 Metabolite levels (small molecules and protein measures); CESC cis rs13064411 0.696 rs6783965 chr3:113198722 C/T cg18753928 chr3:113234510 CCDC52 -0.48 -5.62 -0.33 4.78e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg22862634 chr11:62369728 EML3;MTA2 0.5 6.58 0.37 2.44e-10 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs963731 0.579 rs1531021 chr2:39199955 C/G cg04010122 chr2:39346883 SOS1 -0.58 -5.13 -0.3 5.48e-7 Corticobasal degeneration; CESC cis rs7824557 0.564 rs7839307 chr8:11198792 A/G cg21775007 chr8:11205619 TDH 0.54 7.89 0.44 7.8500000000000006e-14 Retinal vascular caliber; CESC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.52 5.39 0.31 1.54e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg25019033 chr10:957182 NA -0.65 -6.53 -0.37 3.33e-10 Eosinophil percentage of granulocytes; CESC cis rs11122272 0.735 rs2790873 chr1:231539685 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -6.93 -0.39 3.24e-11 Hemoglobin concentration; CESC cis rs798766 1.000 rs7682402 chr4:1743343 G/A cg10756475 chr4:1757242 NA 0.47 6.12 0.35 3.31e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg26597838 chr10:835615 NA 0.7 6.45 0.37 5.29e-10 Eosinophil percentage of granulocytes; CESC cis rs7572733 0.555 rs7590828 chr2:198940251 A/G cg03934865 chr2:198174659 NA -0.37 -5.2 -0.3 3.9e-7 Dermatomyositis; CESC cis rs1003719 0.699 rs1015549 chr21:38448880 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.64 0.47 5.56e-16 Eye color traits; CESC cis rs1797885 0.844 rs1699351 chr3:12560317 A/G cg26432171 chr3:12704882 RAF1 -0.47 -5.83 -0.34 1.61e-8 Immature fraction of reticulocytes; CESC cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg24110177 chr3:50126178 RBM5 0.56 7.68 0.43 2.99e-13 Body mass index; CESC cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg10523679 chr1:76189770 ACADM 0.74 9.84 0.52 1.11e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11792861 0.781 rs11789252 chr9:111762010 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 6.7 0.38 1.23e-10 Menarche (age at onset); CESC trans rs3087243 0.755 rs863603 chr2:204694974 C/T cg01841312 chr10:38069945 NA 0.38 6.33 0.36 1.03e-9 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs72772090 0.539 rs72773942 chr5:96123366 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.26 -0.31 3.01e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.31 -0.36 1.15e-9 Developmental language disorder (linguistic errors); CESC trans rs801193 0.844 rs732465 chr7:65998450 T/C cg26939375 chr7:64535504 NA 0.53 7.31 0.41 3.22e-12 Aortic root size; CESC cis rs6032067 0.929 rs6017512 chr20:43835038 G/A cg11264863 chr20:43835661 SEMG1 0.48 5.26 0.31 2.98e-7 Blood protein levels; CESC cis rs2625529 0.652 rs8030815 chr15:72403001 T/C cg16672083 chr15:72433130 SENP8 0.42 6.57 0.37 2.6200000000000003e-10 Red blood cell count; CESC trans rs12429889 0.831 rs9600245 chr13:74746219 G/A cg03455107 chr17:54509207 ANKFN1 -0.35 -6.0 -0.35 6.62e-9 Sudden cardiac arrest; CESC cis rs11722228 0.539 rs62287552 chr4:10153197 C/T cg14348967 chr4:10160060 NA -0.39 -5.05 -0.3 8.22e-7 Gout;Urate levels;Serum uric acid levels; CESC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.84 0.43 1.14e-13 Prudent dietary pattern; CESC cis rs6460942 0.915 rs62447641 chr7:12488764 G/A cg10578991 chr7:12443926 VWDE -0.48 -5.15 -0.3 5.04e-7 Coronary artery disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23739036 chr1:2343736 PEX10 -0.49 -6.26 -0.36 1.56e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg11494091 chr17:61959527 GH2 0.75 12.85 0.62 1.09e-29 Prudent dietary pattern; CESC cis rs4561483 0.583 rs12149833 chr16:12003723 C/T cg08843971 chr16:11963173 GSPT1 0.46 6.46 0.37 5.02e-10 Testicular germ cell tumor; CESC cis rs4727027 0.704 rs12704070 chr7:148902789 G/A cg23158103 chr7:148848205 ZNF398 -0.32 -5.13 -0.3 5.65e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs561341 1.000 rs546748 chr17:30324293 A/C cg19193384 chr17:30244184 NA -0.53 -6.22 -0.36 1.89e-9 Hip circumference adjusted for BMI; CESC cis rs9611565 0.918 rs12484074 chr22:41752747 G/A cg06481639 chr22:41940642 POLR3H -0.69 -7.12 -0.4 9.86e-12 Vitiligo; CESC cis rs7662987 0.517 rs2602866 chr4:100034997 A/G cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC cis rs6545883 0.931 rs778765 chr2:61786385 A/T cg15711740 chr2:61764176 XPO1 -0.43 -5.2 -0.3 3.98e-7 Tuberculosis; CESC trans rs10242455 0.702 rs59240302 chr7:99072991 C/G cg09045935 chr12:6379348 NA 0.89 7.38 0.41 2.01e-12 Blood metabolite levels; CESC cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg11752832 chr7:134001865 SLC35B4 0.53 6.65 0.38 1.65e-10 Mean platelet volume; CESC cis rs1256061 0.603 rs1256045 chr14:64729760 A/C cg21174375 chr14:64681225 SYNE2 0.51 6.82 0.39 6.15e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg11366901 chr6:160182831 ACAT2 0.83 10.38 0.54 2.06e-21 Age-related macular degeneration (geographic atrophy); CESC cis rs62408225 1.000 rs1604831 chr6:90967197 G/A cg06866423 chr6:90926672 BACH2 0.46 5.55 0.32 6.84e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2708240 0.504 rs851704 chr7:147538431 G/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.06 -0.3 7.99e-7 QT interval (drug interaction); CESC cis rs11785400 0.793 rs4736366 chr8:143742413 C/T cg24634471 chr8:143751801 JRK 0.49 6.06 0.35 4.78e-9 Schizophrenia; CESC cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10751667 0.643 rs11246344 chr11:933783 A/C cg06064525 chr11:970664 AP2A2 -0.52 -10.37 -0.54 2.34e-21 Alzheimer's disease (late onset); CESC cis rs2228479 1.000 rs2228479 chr16:89985940 G/A cg04013166 chr16:89971882 TCF25 0.77 6.44 0.37 5.6e-10 Skin colour saturation; CESC cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg26597838 chr10:835615 NA 0.85 9.06 0.49 2.95e-17 Eosinophil percentage of granulocytes; CESC cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.94 0.34 8.86e-9 Tonsillectomy; CESC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg16743903 chr16:89593216 SPG7 -0.42 -5.5 -0.32 9.16e-8 Multiple myeloma (IgH translocation); CESC cis rs9828933 0.766 rs864975 chr3:63885615 T/C cg16258503 chr3:63850278 ATXN7;THOC7 0.94 8.55 0.46 1.02e-15 Type 2 diabetes; CESC cis rs12497850 1.000 rs12497850 chr3:48748989 G/T cg07636037 chr3:49044803 WDR6 0.94 16.03 0.7 6.6e-41 Parkinson's disease; CESC cis rs9902453 0.845 rs2617875 chr17:28090024 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.23 0.45 8.59e-15 Coffee consumption (cups per day); CESC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg08027265 chr7:2291960 NA -0.34 -5.08 -0.3 7.23e-7 Bipolar disorder and schizophrenia; CESC cis rs6912958 0.712 rs2754262 chr6:88405585 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.28 -0.36 1.37e-9 Monocyte percentage of white cells; CESC cis rs9549260 0.753 rs9549238 chr13:41179321 G/A cg21288729 chr13:41239152 FOXO1 0.53 5.05 0.3 8.14e-7 Red blood cell count; CESC cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg26408565 chr15:76604113 ETFA -0.42 -6.07 -0.35 4.47e-9 Blood metabolite levels; CESC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg10691866 chr7:65817282 TPST1 0.32 5.3 0.31 2.49e-7 Aortic root size; CESC cis rs250677 0.522 rs3763022 chr5:148381078 A/G cg18129178 chr5:148520854 ABLIM3 -0.39 -5.04 -0.3 8.59e-7 Breast cancer; CESC cis rs10791097 0.694 rs12361892 chr11:130744490 T/G cg12179176 chr11:130786555 SNX19 0.64 9.93 0.52 5.73e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg06456125 chr7:65229604 NA 0.39 5.13 0.3 5.57e-7 Aortic root size; CESC cis rs6840258 0.941 rs7665282 chr4:87900850 C/T cg08197287 chr4:87952173 AFF1 -0.39 -5.11 -0.3 6.15e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs11112613 0.609 rs11112585 chr12:105933442 A/G cg03607813 chr12:105948248 NA -0.54 -5.75 -0.33 2.47e-8 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs7084402 0.935 rs4948523 chr10:60339098 A/C cg07615347 chr10:60278583 BICC1 0.57 8.6 0.47 6.98e-16 Refractive error; CESC cis rs8114671 0.562 rs6119545 chr20:33522869 T/C cg06115741 chr20:33292138 TP53INP2 0.48 5.79 0.34 1.97e-8 Height; CESC cis rs12220238 1.000 rs11000890 chr10:75904073 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.52 0.37 3.45e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg18404041 chr3:52824283 ITIH1 -0.47 -7.71 -0.43 2.56e-13 Bipolar disorder; CESC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs10197940 0.662 rs4592848 chr2:152337822 G/A cg19508488 chr2:152266495 RIF1 0.49 5.36 0.31 1.85e-7 Lung cancer; CESC cis rs4561483 0.801 rs33643 chr16:11986149 A/G cg08843971 chr16:11963173 GSPT1 -0.56 -8.39 -0.46 2.97e-15 Testicular germ cell tumor; CESC cis rs72781680 0.898 rs17762651 chr2:24115922 A/G cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs7772486 0.790 rs11760 chr6:146205973 G/T cg23711669 chr6:146136114 FBXO30 0.92 13.35 0.63 1.96e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs4722585 0.605 rs10268883 chr7:26200417 C/T cg07876897 chr7:26191696 NFE2L3 0.47 5.96 0.34 8.1e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); CESC cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3806843 0.868 rs2262573 chr5:140123627 T/A cg26395211 chr5:140044315 WDR55 0.4 5.2 0.3 3.99e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7122539 0.646 rs627330 chr11:66602099 C/T cg24851651 chr11:66362959 CCS 0.49 7.11 0.4 1.08e-11 HIV-1 susceptibility; CESC cis rs9291683 0.546 rs13139055 chr4:10038924 G/T cg02734326 chr4:10020555 SLC2A9 0.45 6.19 0.36 2.3e-9 Bone mineral density; CESC trans rs9467711 0.659 rs13220261 chr6:26499185 C/T cg06606381 chr12:133084897 FBRSL1 -0.96 -7.07 -0.4 1.39e-11 Autism spectrum disorder or schizophrenia; CESC cis rs80130819 0.748 rs2732446 chr12:48690177 T/C cg05342945 chr12:48394962 COL2A1 -0.48 -5.16 -0.3 4.82e-7 Prostate cancer; CESC cis rs1506636 1.000 rs7357252 chr7:123369856 C/T cg03229431 chr7:123269106 ASB15 -0.52 -6.91 -0.39 3.58e-11 Plateletcrit;Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18101314 chr11:72504857 STARD10 0.6 6.84 0.39 5.38e-11 Gut microbiome composition (summer); CESC cis rs6582630 0.555 rs2004152 chr12:38478951 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.74 0.38 9.64e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg07648498 chr16:89883185 FANCA 0.48 6.01 0.35 5.98e-9 Vitiligo; CESC cis rs35520189 0.591 rs12995439 chr2:113703646 T/C cg06156847 chr2:113672199 IL1F7 0.37 5.17 0.3 4.63e-7 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs1843834 0.539 rs10177898 chr2:225437552 C/T cg22455342 chr2:225449267 CUL3 0.7 9.62 0.51 5.41e-19 IgE levels in asthmatics (D.p. specific); CESC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg00431813 chr7:1051703 C7orf50 -0.35 -5.4 -0.31 1.49e-7 Longevity;Endometriosis; CESC cis rs79349575 0.783 rs4794003 chr17:47029904 C/T cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs7107174 0.892 rs1893449 chr11:77968977 G/C cg02023728 chr11:77925099 USP35 0.48 6.34 0.36 9.87e-10 Testicular germ cell tumor; CESC cis rs5758659 0.714 rs6002626 chr22:42517989 C/G cg15557168 chr22:42548783 NA 0.48 7.42 0.41 1.62e-12 Cognitive function; CESC cis rs6815814 0.950 rs11722889 chr4:38810975 C/T cg02016764 chr4:38805732 TLR1 -0.62 -7.43 -0.42 1.5e-12 Breast cancer; CESC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs10905065 0.930 rs9423726 chr10:5737979 A/G cg11519256 chr10:5708881 ASB13 -0.42 -5.43 -0.32 1.29e-7 Menopause (age at onset); CESC cis rs12190007 0.573 rs13202383 chr6:169826544 A/G cg15038512 chr6:170123185 PHF10 -0.51 -7.29 -0.41 3.68e-12 Obesity-related traits; CESC cis rs7586879 0.598 rs6724772 chr2:25128730 T/C cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.04e-11 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23125901 chr10:504452 DIP2C -0.52 -6.2 -0.36 2.18e-9 Gut microbiome composition (summer); CESC cis rs2996428 0.643 rs6424056 chr1:3722486 G/A cg13057898 chr1:3703894 LRRC47 0.47 6.46 0.37 4.98e-10 Red cell distribution width; CESC cis rs12681288 0.676 rs935820 chr8:1022168 A/G cg15309053 chr8:964076 NA 0.37 6.47 0.37 4.79e-10 Schizophrenia; CESC cis rs8078723 0.714 rs2241244 chr17:38153554 G/C cg17344932 chr17:38183730 MED24;SNORD124 0.38 5.52 0.32 8.15e-8 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs72781680 0.611 rs6720131 chr2:24364736 C/T cg08917208 chr2:24149416 ATAD2B 0.63 6.04 0.35 5.28e-9 Lymphocyte counts; CESC cis rs6732160 0.845 rs6752507 chr2:73385158 C/G cg01422370 chr2:73384389 NA 0.42 7.15 0.4 8.29e-12 Intelligence (multi-trait analysis); CESC cis rs2251381 0.750 rs2251087 chr21:30527999 C/T cg08807101 chr21:30365312 RNF160 0.7 8.59 0.47 7.75e-16 Selective IgA deficiency; CESC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg10074409 chr1:209979377 IRF6 0.37 6.02 0.35 5.89e-9 Cleft lip with or without cleft palate; CESC cis rs9611565 0.592 rs80477 chr22:42001183 C/T cg06481639 chr22:41940642 POLR3H 0.57 6.31 0.36 1.17e-9 Vitiligo; CESC cis rs6088580 0.634 rs6579165 chr20:32994715 A/G cg06115741 chr20:33292138 TP53INP2 -0.46 -5.98 -0.34 7.28e-9 Glomerular filtration rate (creatinine); CESC cis rs2228479 0.618 rs17233623 chr16:89811209 C/T cg04287289 chr16:89883240 FANCA 0.67 5.53 0.32 7.48e-8 Skin colour saturation; CESC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Depression; CESC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg19717773 chr7:2847554 GNA12 -0.53 -7.83 -0.43 1.15e-13 Height; CESC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs34779708 0.931 rs34087268 chr10:35346724 T/G cg03585969 chr10:35415529 CREM 0.77 10.01 0.52 3.32e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs7839040 0.698 rs11774876 chr8:82929277 G/A cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg18252515 chr7:66147081 NA 0.39 5.2 0.3 4.01e-7 Aortic root size; CESC cis rs2180341 0.920 rs7756880 chr6:127683999 A/T cg27446573 chr6:127587934 RNF146 1.06 15.51 0.69 4.62e-39 Breast cancer; CESC cis rs2243480 1.000 rs160648 chr7:65543384 C/A cg18252515 chr7:66147081 NA -1.34 -13.59 -0.64 2.89e-32 Diabetic kidney disease; CESC cis rs7160336 0.641 rs10136002 chr14:74681775 T/C cg08255017 chr14:74727001 VSX2 -0.38 -5.53 -0.32 7.71e-8 Blood protein levels; CESC cis rs79057730 0.599 rs9458 chr7:825494 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.87 -8.01 -0.44 3.67e-14 Initial pursuit acceleration; CESC cis rs561341 0.883 rs2074102 chr17:30228884 G/A cg13647721 chr17:30228624 UTP6 0.59 5.42 0.32 1.33e-7 Hip circumference adjusted for BMI; CESC cis rs7959452 0.605 rs12819406 chr12:69696400 G/T cg14784868 chr12:69753453 YEATS4 0.73 10.59 0.55 4.42e-22 Blood protein levels; CESC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg02951883 chr7:2050386 MAD1L1 -0.57 -7.76 -0.43 1.81e-13 Bipolar disorder and schizophrenia; CESC cis rs1949733 0.656 rs2688224 chr4:8404700 C/G cg11789530 chr4:8429930 ACOX3 0.69 9.69 0.51 3.36e-19 Response to antineoplastic agents; CESC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg10053473 chr17:62856997 LRRC37A3 -0.66 -6.94 -0.39 2.96e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg03467027 chr4:99064603 C4orf37 0.48 6.04 0.35 5.29e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.692 rs4360890 chr15:77173295 G/A cg22467129 chr15:76604101 ETFA -0.35 -5.23 -0.31 3.42e-7 Blood metabolite levels; CESC cis rs11098499 0.954 rs6849171 chr4:120409549 G/A cg09307838 chr4:120376055 NA 0.96 13.98 0.65 1.21e-33 Corneal astigmatism; CESC trans rs1557351 0.723 rs1942345 chr18:54721169 G/C cg11433624 chr6:7146702 RREB1 0.38 6.14 0.35 2.94e-9 Multiple sclerosis (age of onset); CESC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg18337363 chr3:52569053 NT5DC2 0.29 5.26 0.31 3.02e-7 Electroencephalogram traits; CESC cis rs7927592 0.956 rs55816191 chr11:68262979 G/T cg20283391 chr11:68216788 NA -0.49 -6.29 -0.36 1.34e-9 Total body bone mineral density; CESC cis rs2797160 0.967 rs1739358 chr6:126019736 G/A cg05901451 chr6:126070800 HEY2 0.46 6.54 0.37 3.08e-10 Endometrial cancer; CESC cis rs2932538 0.922 rs4838961 chr1:113163967 T/C cg22162597 chr1:113214053 CAPZA1 -0.58 -7.44 -0.42 1.45e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs11792861 0.591 rs10979632 chr9:111732140 G/C cg13535736 chr9:111863775 C9orf5 -0.4 -5.89 -0.34 1.18e-8 Menarche (age at onset); CESC cis rs7671266 0.668 rs10002562 chr4:10159736 C/G cg00071950 chr4:10020882 SLC2A9 -0.56 -6.0 -0.35 6.43e-9 Cardiovascular disease risk factors; CESC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg05863683 chr7:1912471 MAD1L1 0.43 6.29 0.36 1.33e-9 Bipolar disorder and schizophrenia; CESC cis rs644148 0.738 rs2686768 chr19:44995990 C/T cg15540054 chr19:45004280 ZNF180 -0.43 -5.35 -0.31 1.94e-7 Personality dimensions; CESC cis rs6502050 0.736 rs11658040 chr17:80059891 C/T cg23985595 chr17:80112537 CCDC57 0.4 6.14 0.35 2.98e-9 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24418621 chr11:129993688 APLP2 0.51 6.06 0.35 4.69e-9 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs4235388 chr4:17682030 G/A cg16339924 chr4:17578868 LAP3 0.48 6.13 0.35 3.11e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1775715 0.870 rs1755072 chr10:32266642 A/G cg18675610 chr10:32216311 ARHGAP12 -0.33 -5.04 -0.3 8.46e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs854765 0.547 rs2955384 chr17:17939573 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.58 8.42 0.46 2.42e-15 Total body bone mineral density; CESC cis rs9300255 0.739 rs12824957 chr12:123750228 T/C cg00376283 chr12:123451042 ABCB9 -0.68 -6.99 -0.39 2.22e-11 Neutrophil percentage of white cells; CESC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg02475777 chr4:1388615 CRIPAK 0.7 8.78 0.47 2e-16 Longevity; CESC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg03934478 chr11:495069 RNH1 0.55 5.31 0.31 2.37e-7 Body mass index; CESC cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg13114125 chr14:105738426 BRF1 -0.81 -10.2 -0.53 8.28e-21 Mean platelet volume;Platelet distribution width; CESC cis rs4253772 0.591 rs6008545 chr22:46686375 C/T cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.53 5.26 0.31 3.02e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7586879 0.521 rs7597332 chr2:25075675 A/G cg01884057 chr2:25150051 NA 0.37 7.18 0.4 7.06e-12 Body mass index; CESC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4253772 0.591 rs7291444 chr22:46656246 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.67 7.99 0.44 4.2e-14 LDL cholesterol;Cholesterol, total; CESC trans rs11098499 0.754 rs11732087 chr4:120239831 A/G cg25214090 chr10:38739885 LOC399744 0.61 8.4 0.46 2.69e-15 Corneal astigmatism; CESC cis rs1942 0.837 rs12440045 chr15:41782684 A/C cg20272979 chr15:41787780 ITPKA 0.37 5.4 0.32 1.45e-7 Eosinophil percentage of granulocytes; CESC cis rs3796619 1.000 rs55741287 chr4:1094670 T/C cg27284194 chr4:1044797 NA 0.37 5.56 0.32 6.46e-8 Recombination rate (males); CESC cis rs6088590 0.561 rs6059926 chr20:33164804 C/T cg24642439 chr20:33292090 TP53INP2 0.63 8.5 0.46 1.36e-15 Coronary artery disease; CESC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg26769984 chr7:1090371 C7orf50 0.6 6.77 0.38 8.2e-11 Bronchopulmonary dysplasia; CESC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg14893161 chr1:205819251 PM20D1 0.86 14.44 0.66 2.81e-35 Menarche (age at onset); CESC cis rs611744 0.647 rs12675265 chr8:109268805 C/T cg21045802 chr8:109455806 TTC35 0.5 6.25 0.36 1.62e-9 Dupuytren's disease; CESC cis rs3806843 1.000 rs6885319 chr5:140200611 A/C cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.13 -0.3 5.71e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg00166722 chr3:10149974 C3orf24 0.45 5.84 0.34 1.54e-8 Alzheimer's disease; CESC cis rs4906332 1.000 rs2065018 chr14:103879187 C/T cg09975044 chr14:104007538 NA -0.45 -6.27 -0.36 1.45e-9 Coronary artery disease; CESC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg22823121 chr1:150693482 HORMAD1 0.36 5.12 0.3 5.88e-7 Melanoma; CESC cis rs733592 0.507 rs7304428 chr12:48494275 T/G cg24011408 chr12:48396354 COL2A1 -0.51 -8.57 -0.47 8.97e-16 Plateletcrit; CESC cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg00033643 chr7:134001901 SLC35B4 0.44 5.59 0.32 5.71e-8 Mean platelet volume; CESC cis rs6547741 0.935 rs4666005 chr2:27855239 A/G cg27432699 chr2:27873401 GPN1 0.46 6.4 0.37 7.11e-10 Oral cavity cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07335843 chr2:133030691 NA -0.54 -7.19 -0.4 6.55e-12 Gut microbiome composition (summer); CESC cis rs1144333 1.000 rs1021464 chr1:76375415 G/A cg10523679 chr1:76189770 ACADM 0.56 5.15 0.3 5e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs10189230 0.935 rs6731133 chr2:222359155 C/T cg14652038 chr2:222343519 EPHA4 0.34 6.8 0.39 6.79e-11 Urate levels in lean individuals; CESC cis rs9473147 0.543 rs9473119 chr6:47450618 G/A cg20196966 chr6:47445060 CD2AP 0.4 5.1 0.3 6.36e-7 Platelet distribution width;Mean platelet volume; CESC cis rs1499614 0.831 rs3800822 chr7:66147149 A/G cg18252515 chr7:66147081 NA 1.42 14.47 0.66 2.33e-35 Gout; CESC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs901683 1.000 rs35349326 chr10:45973624 A/G cg16031567 chr10:46195673 NA -0.75 -5.04 -0.3 8.78e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs9287719 0.934 rs6706763 chr2:10751407 C/T cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.56 -0.32 6.59e-8 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24536114 chr1:89448405 RBMXL1;CCBL2 -0.54 -6.75 -0.38 9.54e-11 Gut microbiome composition (summer); CESC trans rs983392 0.679 rs7121656 chr11:60024008 C/T cg13921652 chr1:144931966 PDE4DIP 0.48 6.06 0.35 4.63e-9 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17816495 chr19:19030203 DDX49;COPE 0.65 7.44 0.42 1.39e-12 Gut microbiome composition (summer); CESC trans rs61931739 0.534 rs11053005 chr12:34091626 A/C cg26384229 chr12:38710491 ALG10B 0.59 8.25 0.45 7.65e-15 Morning vs. evening chronotype; CESC cis rs6032067 0.777 rs62208416 chr20:43803226 G/A cg11264863 chr20:43835661 SEMG1 0.51 5.43 0.32 1.25e-7 Blood protein levels; CESC cis rs10927875 0.501 rs9660676 chr1:16279041 C/T cg21385522 chr1:16154831 NA -0.89 -9.91 -0.52 6.55e-20 Dilated cardiomyopathy; CESC cis rs8020095 0.528 rs10147362 chr14:67820372 A/T cg19548862 chr14:67692701 FAM71D -0.45 -5.39 -0.31 1.52e-7 Depression (quantitative trait); CESC cis rs637571 0.654 rs1058068 chr11:65667796 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.44 5.42 0.32 1.33e-7 Eosinophil percentage of white cells; CESC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg19748678 chr4:122722346 EXOSC9 0.79 9.99 0.52 3.82e-20 Type 2 diabetes; CESC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs9611565 0.570 rs12159188 chr22:42121125 A/T cg17376030 chr22:41985996 PMM1 -0.56 -6.11 -0.35 3.48e-9 Vitiligo; CESC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg14893161 chr1:205819251 PM20D1 0.71 11.88 0.59 2.18e-26 Monocyte percentage of white cells; CESC cis rs12477438 0.798 rs12468419 chr2:99579680 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.91 -0.48 8.52e-17 Chronic sinus infection; CESC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg19592336 chr6:28129416 ZNF389 0.61 7.98 0.44 4.44e-14 Depression; CESC cis rs6582630 0.519 rs8189623 chr12:38351436 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.95 0.56 2.81e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs6460942 0.597 rs4719315 chr7:12528634 A/G cg06484146 chr7:12443880 VWDE -0.71 -7.7 -0.43 2.7e-13 Coronary artery disease; CESC cis rs7640424 0.819 rs34937412 chr3:107829484 G/C cg09227934 chr3:107805635 CD47 -0.48 -6.05 -0.35 4.81e-9 Body mass index; CESC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg12648201 chr2:27665141 KRTCAP3 -0.31 -5.65 -0.33 4.22e-8 Menopause (age at onset); CESC cis rs9303401 0.659 rs7216648 chr17:56790858 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26396086 chr1:247494708 ZNF496 0.56 6.37 0.36 8.53e-10 Gut microbiome composition (summer); CESC cis rs17601876 0.814 rs28520437 chr15:51553277 C/T cg19946085 chr15:51559439 CYP19A1 -0.34 -5.41 -0.32 1.44e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg09323728 chr8:95962352 TP53INP1 0.27 5.31 0.31 2.28e-7 Type 2 diabetes; CESC cis rs11030122 0.702 rs10835311 chr11:3949027 G/T cg18678763 chr11:4115507 RRM1 -0.46 -6.08 -0.35 4.1e-9 Mean platelet volume;Platelet distribution width; CESC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg27535305 chr1:53392650 SCP2 -0.34 -5.57 -0.32 6.16e-8 Monocyte count; CESC cis rs12464559 0.522 rs6715027 chr2:152626657 T/C cg01189475 chr2:152685088 ARL5A 0.72 6.98 0.39 2.38e-11 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs2735413 0.957 rs2735414 chr16:78053658 C/A cg04733911 chr16:78082701 NA -0.42 -6.24 -0.36 1.74e-9 Systolic blood pressure (alcohol consumption interaction); CESC cis rs910316 0.737 rs175065 chr14:75494983 T/C cg08847533 chr14:75593920 NEK9 -0.89 -15.46 -0.69 6.99e-39 Height; CESC cis rs13191362 0.507 rs6907151 chr6:163200701 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.5 5.93 0.34 9.18e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2228479 0.850 rs11649510 chr16:89851004 A/G cg19635926 chr16:89946313 TCF25 0.67 5.08 0.3 7.08e-7 Skin colour saturation; CESC cis rs921968 0.643 rs485765 chr2:219480804 C/G cg02176678 chr2:219576539 TTLL4 0.32 5.19 0.3 4.14e-7 Mean corpuscular hemoglobin concentration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16424519 chr16:21531031 SLC7A5P2 -0.44 -6.25 -0.36 1.62e-9 Gambling; CESC cis rs7666738 0.830 rs4699580 chr4:98930673 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg13175981 chr1:150552382 MCL1 0.71 10.45 0.54 1.22e-21 Tonsillectomy; CESC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg18538332 chr22:24372958 LOC391322 -0.71 -10.69 -0.55 2.13e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg25036284 chr2:26402008 FAM59B -0.83 -9.37 -0.5 3.23e-18 Gut microbiome composition (summer); CESC cis rs2354432 1.000 rs2120003 chr1:146690635 A/G cg25205988 chr1:146714368 CHD1L 0.7 6.45 0.37 5.42e-10 Mitochondrial DNA levels; CESC cis rs6754311 0.731 rs309160 chr2:136685228 C/T cg07169764 chr2:136633963 MCM6 0.68 8.49 0.46 1.51e-15 Mosquito bite size; CESC trans rs12681287 0.517 rs13249753 chr8:87513216 A/G cg27317242 chr8:23145699 R3HCC1 -0.51 -6.12 -0.35 3.28e-9 Caudate activity during reward; CESC cis rs9581857 0.685 rs9319371 chr13:28042564 A/G cg01674679 chr13:27998804 GTF3A -0.69 -5.52 -0.32 8.1e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs921968 0.541 rs496674 chr2:219432569 G/A cg02176678 chr2:219576539 TTLL4 0.5 8.91 0.48 8.15e-17 Mean corpuscular hemoglobin concentration; CESC cis rs2108225 0.872 rs2051954 chr7:107441097 G/C cg18560240 chr7:107437656 SLC26A3 -0.43 -5.95 -0.34 8.65e-9 Ulcerative colitis; CESC cis rs1707322 1.000 rs4460583 chr1:46449918 C/G cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg23158103 chr7:148848205 ZNF398 -0.36 -5.2 -0.3 4.05e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg04553112 chr3:125709451 NA -0.48 -5.41 -0.32 1.44e-7 Blood pressure (smoking interaction); CESC cis rs7208859 0.623 rs11657369 chr17:29136468 G/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9457247 1.000 rs409356 chr6:167405226 T/A cg23791538 chr6:167370224 RNASET2 -0.59 -8.42 -0.46 2.44e-15 Crohn's disease; CESC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg25036284 chr2:26402008 FAM59B -0.57 -6.54 -0.37 3.12e-10 Gut microbiome composition (summer); CESC cis rs7542091 0.704 rs7550330 chr1:210044587 G/A cg25204440 chr1:209979598 IRF6 0.37 5.1 0.3 6.55e-7 Monobrow; CESC cis rs881375 0.678 rs9886724 chr9:123665019 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.83 0.39 5.66e-11 Rheumatoid arthritis; CESC cis rs6665290 0.901 rs12410103 chr1:227197408 T/C cg10327440 chr1:227177885 CDC42BPA -1.22 -33.0 -0.9 7.42e-96 Myeloid white cell count; CESC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg16545954 chr1:2118288 C1orf86 -0.31 -5.7 -0.33 3.13e-8 Height; CESC cis rs10752881 0.775 rs2147585 chr1:183074875 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.05e-34 Colorectal cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg20032723 chr11:126174041 DCPS 0.46 6.3 0.36 1.25e-9 Systemic lupus erythematosus; CESC cis rs6500395 0.928 rs12934788 chr16:48706343 C/A cg04672837 chr16:48644449 N4BP1 -0.52 -6.64 -0.38 1.75e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4919694 0.808 rs77521106 chr10:104980726 G/T cg04362960 chr10:104952993 NT5C2 0.79 5.91 0.34 1.03e-8 Arsenic metabolism; CESC cis rs9303280 0.776 rs9910826 chr17:38035648 A/G cg19468946 chr17:37922297 IKZF3 -0.41 -5.42 -0.32 1.31e-7 Self-reported allergy; CESC trans rs4957048 0.541 rs12519390 chr5:676546 A/G cg25482853 chr8:67687455 SGK3 0.99 9.0 0.48 4.53e-17 Ulcerative colitis; CESC cis rs1478897 0.898 rs2248932 chr8:11391650 A/G cg09528494 chr8:11338675 NA -0.28 -5.12 -0.3 5.99e-7 Systemic lupus erythematosus; CESC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg14196790 chr5:131705035 SLC22A5 0.34 5.21 0.3 3.82e-7 Breast cancer;Mosquito bite size; CESC cis rs11690935 0.959 rs12692973 chr2:172642057 A/G cg13550731 chr2:172543902 DYNC1I2 0.96 14.96 0.68 4.09e-37 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11141692 chr4:111866916 NA -0.45 -6.21 -0.36 2.04e-9 Gut microbiota (bacterial taxa); CESC trans rs10511652 1.000 rs10511652 chr9:18362865 A/G cg18106800 chr5:94890715 ARSK;TTC37 0.44 6.08 0.35 4.29e-9 Myopia; CESC cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg26597838 chr10:835615 NA 0.76 7.15 0.4 8.67e-12 Eosinophil percentage of granulocytes; CESC cis rs9818758 0.607 rs34823813 chr3:49749976 G/A cg00383909 chr3:49044727 WDR6 0.84 5.53 0.32 7.76e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg23262073 chr20:60523788 NA 0.54 7.63 0.42 4.31e-13 Obesity-related traits; CESC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg17724175 chr1:150552817 MCL1 -0.45 -7.33 -0.41 2.74e-12 Tonsillectomy; CESC cis rs9640161 0.742 rs2108853 chr7:150017589 A/C cg21361702 chr7:150065534 REPIN1 0.55 6.45 0.37 5.33e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs1355223 0.583 rs2941058 chr11:34880245 C/G cg18508148 chr11:34937573 PDHX;APIP 0.41 5.31 0.31 2.33e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs67311347 1.000 rs7628247 chr3:40512682 G/T cg24209194 chr3:40518798 ZNF619 -0.53 -6.88 -0.39 4.25e-11 Renal cell carcinoma; CESC cis rs7582720 1.000 rs72936830 chr2:203769803 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs3020736 0.500 rs5996111 chr22:42493902 C/T cg12850546 chr22:42539477 CYP2D7P1 0.45 5.3 0.31 2.4e-7 Autism spectrum disorder or schizophrenia; CESC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg11494091 chr17:61959527 GH2 0.74 12.63 0.61 6.3e-29 Prudent dietary pattern; CESC cis rs10461617 0.541 rs7715822 chr5:56043600 G/T cg12311346 chr5:56204834 C5orf35 -0.62 -5.77 -0.33 2.24e-8 Type 2 diabetes; CESC cis rs11920090 0.858 rs10513688 chr3:170727218 G/A cg09710316 chr3:170744871 SLC2A2 0.51 5.84 0.34 1.53e-8 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg09366641 chr1:153643528 ILF2 -0.39 -6.2 -0.36 2.17e-9 Vertical cup-disc ratio; CESC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg08392591 chr16:89556376 ANKRD11 0.61 8.31 0.45 5.13e-15 Multiple myeloma (IgH translocation); CESC cis rs10463316 0.894 rs3846712 chr5:150759813 C/A cg03212797 chr5:150827313 SLC36A1 -0.44 -5.74 -0.33 2.54e-8 Metabolite levels (Pyroglutamine); CESC cis rs3820068 0.581 rs1547033 chr1:15918988 T/C cg17385448 chr1:15911702 AGMAT 0.44 7.11 0.4 1.08e-11 Systolic blood pressure; CESC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg20151795 chr6:28129481 ZNF389 0.37 5.23 0.31 3.51e-7 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12805764 chr1:153631263 SNAPIN 0.58 6.2 0.36 2.2e-9 Gut microbiome composition (summer); CESC cis rs60154123 0.772 rs614167 chr1:210425895 T/C cg23283495 chr1:209979779 IRF6 0.44 5.3 0.31 2.4e-7 Coronary artery disease; CESC cis rs11098499 1.000 rs11726229 chr4:120211580 C/T cg09307838 chr4:120376055 NA 0.88 11.91 0.59 1.75e-26 Corneal astigmatism; CESC cis rs4237845 0.551 rs116263297 chr12:58273445 A/C cg00677455 chr12:58241039 CTDSP2 0.8 10.71 0.55 1.82e-22 Intelligence (multi-trait analysis); CESC cis rs901683 1.000 rs71499565 chr10:45977715 T/C cg16031567 chr10:46195673 NA -0.75 -5.04 -0.3 8.78e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs748404 0.631 rs6493086 chr15:43655394 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.69 0.43 2.83e-13 Lung cancer; CESC cis rs7089973 0.604 rs3758603 chr10:116605368 T/C cg25233709 chr10:116636983 FAM160B1 0.38 6.08 0.35 4.13e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg20243544 chr17:37824526 PNMT -0.49 -6.09 -0.35 3.9e-9 Glomerular filtration rate (creatinine); CESC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg23102388 chr7:1867652 MAD1L1 -0.33 -5.05 -0.3 8.16e-7 Bipolar disorder and schizophrenia; CESC cis rs919433 0.783 rs2565158 chr2:198236103 T/A cg10820045 chr2:198174542 NA 0.41 5.93 0.34 9.34e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7678296 0.764 rs1426408 chr4:37183131 G/C cg06805348 chr4:37245195 KIAA1239 0.44 5.15 0.3 5.09e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23210049 chr8:143695893 ARC -0.46 -6.37 -0.36 8.36e-10 Fibrinogen levels; CESC cis rs2599510 0.783 rs2038534 chr2:32659489 G/A cg02381751 chr2:32503542 YIPF4 0.41 5.06 0.3 7.83e-7 Interleukin-18 levels; CESC cis rs1348850 0.793 rs13020788 chr2:178480714 C/A cg22681709 chr2:178499509 PDE11A -0.42 -6.39 -0.37 7.48e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs17052344 0.543 rs2342183 chr17:21738349 G/T cg18423549 chr17:21743878 NA -0.62 -9.14 -0.49 1.65e-17 Cutaneous psoriasis; CESC cis rs3806843 0.648 rs2530233 chr5:140082876 A/G cg16179182 chr5:140090404 VTRNA1-1 0.4 5.14 0.3 5.34e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.83 0.34 1.59e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14975961 chr20:2821322 VPS16;FAM113A 0.51 6.35 0.36 9.22e-10 Gut microbiome composition (summer); CESC cis rs10463316 0.817 rs13355052 chr5:150802003 A/G cg03212797 chr5:150827313 SLC36A1 -0.48 -6.2 -0.36 2.1e-9 Metabolite levels (Pyroglutamine); CESC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.03e-11 Tonsillectomy; CESC cis rs7605827 0.930 rs11685629 chr2:15662271 A/T cg19274914 chr2:15703543 NA 0.37 6.67 0.38 1.51e-10 Educational attainment (years of education); CESC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg00409905 chr10:38381863 ZNF37A 0.43 5.6 0.33 5.49e-8 Extrinsic epigenetic age acceleration; CESC cis rs7949030 0.590 rs12225213 chr11:62350248 T/A cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.17 -0.3 4.67e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs5769765 0.954 rs5769762 chr22:50264042 G/A cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs2243480 1.000 rs67536397 chr7:65947917 G/A cg18252515 chr7:66147081 NA -1.41 -14.24 -0.66 1.46e-34 Diabetic kidney disease; CESC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg03033257 chr22:50311977 ALG12;CRELD2 0.52 5.22 0.31 3.59e-7 Schizophrenia; CESC cis rs3749237 0.595 rs3924462 chr3:49524236 T/G cg06212747 chr3:49208901 KLHDC8B 0.49 6.55 0.37 3.02e-10 Resting heart rate; CESC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg08109568 chr15:31115862 NA 0.73 10.07 0.53 2.13e-20 Huntington's disease progression; CESC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg04234412 chr22:24373322 LOC391322 -0.53 -7.55 -0.42 7.15e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04499690 chr3:93781964 NSUN3;DHFRL1 -0.53 -6.12 -0.35 3.38e-9 Gut microbiome composition (summer); CESC cis rs6460942 1.000 rs75564554 chr7:12319362 A/C cg10578991 chr7:12443926 VWDE -0.61 -6.41 -0.37 6.66e-10 Coronary artery disease; CESC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg12463550 chr7:65579703 CRCP 0.5 6.23 0.36 1.85e-9 Aortic root size; CESC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.98 15.33 0.69 2.11e-38 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16267304 chr21:44985357 HSF2BP -0.62 -7.32 -0.41 3.03e-12 Gut microbiome composition (summer); CESC cis rs34779708 0.931 rs11010077 chr10:35328088 C/T cg04310649 chr10:35416472 CREM 0.52 6.43 0.37 6.04e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.39 0.46 2.96e-15 Menopause (age at onset); CESC cis rs6460942 0.591 rs80311633 chr7:12339690 G/C cg06484146 chr7:12443880 VWDE -0.65 -7.16 -0.4 7.88e-12 Coronary artery disease; CESC cis rs523522 0.847 rs11065132 chr12:120908459 C/T cg12219531 chr12:120966889 COQ5 0.73 9.48 0.5 1.51e-18 High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07032256 chr7:57712753 NA -0.44 -6.12 -0.35 3.28e-9 Gut microbiome composition (summer); CESC trans rs9929218 0.551 rs2296405 chr16:68721470 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.98 -17.2 -0.73 4.82e-45 Colorectal cancer; CESC cis rs863345 0.584 rs6427438 chr1:158454730 C/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.14 -0.4 8.83e-12 Pneumococcal bacteremia; CESC cis rs6429082 0.818 rs291381 chr1:235641924 A/G cg26050004 chr1:235667680 B3GALNT2 0.62 7.83 0.43 1.19e-13 Adiposity; CESC trans rs9369898 1.000 rs6915187 chr6:49423547 G/C cg15934674 chr1:150266645 MRPS21 -0.38 -6.15 -0.35 2.89e-9 Homocysteine levels; CESC cis rs6500395 1.000 rs1039340 chr16:48574637 A/C cg04672837 chr16:48644449 N4BP1 0.49 6.08 0.35 4.18e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9911578 0.835 rs9889419 chr17:56473259 C/T cg12560992 chr17:57184187 TRIM37 0.86 14.32 0.66 7.55e-35 Intelligence (multi-trait analysis); CESC cis rs1062177 0.855 rs6892117 chr5:151264985 C/T cg00977110 chr5:151150581 G3BP1 -0.53 -6.2 -0.36 2.2e-9 Preschool internalizing problems; CESC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg18402987 chr7:1209562 NA 0.74 7.18 0.4 7.11e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2276314 0.857 rs62101393 chr18:33592168 T/C cg19628046 chr18:33552617 C18orf21 0.51 5.76 0.33 2.3e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7089973 0.604 rs7903663 chr10:116609904 G/A cg23260525 chr10:116636907 FAM160B1 0.39 7.2 0.4 6.12e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs300703 0.515 rs300693 chr2:181748 C/A cg21211680 chr2:198530 NA -0.91 -10.69 -0.55 2.11e-22 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21679509 chr7:28219613 JAZF1 -0.41 -6.25 -0.36 1.65e-9 Fibrinogen levels; CESC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.61 8.48 0.46 1.65e-15 Alzheimer's disease; CESC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg12373951 chr3:133503437 NA 0.35 5.11 0.3 6.29e-7 Iron status biomarkers; CESC cis rs727505 0.954 rs1009450 chr7:124628723 C/G cg23710748 chr7:124431027 NA -0.45 -6.97 -0.39 2.58e-11 Lewy body disease; CESC cis rs2732480 0.577 rs2634693 chr12:48706498 C/T cg04545296 chr12:48745243 ZNF641 0.44 7.34 0.41 2.57e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26464185 chr16:1838079 NUBP2 0.47 6.77 0.38 8.43e-11 Fibrinogen levels; CESC cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1801251 1.000 rs2674839 chr2:233669040 G/C cg08000102 chr2:233561755 GIGYF2 0.68 9.91 0.52 6.72e-20 Coronary artery disease; CESC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg18252515 chr7:66147081 NA -0.46 -6.05 -0.35 5e-9 Aortic root size; CESC cis rs10751667 0.643 rs10751671 chr11:944479 T/G cg01483505 chr11:975446 AP2A2 0.38 5.18 0.3 4.44e-7 Alzheimer's disease (late onset); CESC cis rs2742234 0.590 rs2503864 chr10:43666767 G/T cg15436174 chr10:43711423 RASGEF1A -0.5 -5.89 -0.34 1.16e-8 Hirschsprung disease; CESC cis rs1670533 0.818 rs643484 chr4:1085826 A/G cg04106633 chr4:1044584 NA 0.4 5.08 0.3 6.98e-7 Recombination rate (females); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg22081084 chr1:89990230 LRRC8B 0.45 6.3 0.36 1.26e-9 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05993854 chr4:90032464 NA 0.53 6.12 0.35 3.34e-9 Gut microbiome composition (summer); CESC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg04369109 chr6:150039330 LATS1 -0.4 -5.43 -0.32 1.28e-7 Lung cancer; CESC cis rs4930561 0.714 rs7950451 chr11:67962406 C/A cg16338278 chr11:67432957 ALDH3B2 0.42 5.27 0.31 2.77e-7 Breast cancer in childhood cancer survivors;IgG glycosylation; CESC cis rs559928 0.692 rs12146487 chr11:64026639 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.61 5.08 0.3 7.07e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs1670533 1.000 rs6852850 chr4:1052857 C/G cg04106633 chr4:1044584 NA 0.4 5.13 0.3 5.58e-7 Recombination rate (females); CESC cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -9.52 -0.5 1.15e-18 Extrinsic epigenetic age acceleration; CESC cis rs2235642 0.601 rs2235647 chr16:1601331 C/A cg09080909 chr16:1797204 MAPK8IP3 -0.42 -5.82 -0.34 1.69e-8 Coronary artery disease; CESC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.65 0.38 1.66e-10 Bipolar disorder; CESC cis rs933688 1.000 rs10073935 chr5:90742188 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 15.71 0.69 9.34e-40 Smoking behavior; CESC cis rs9911578 0.805 rs1811202 chr17:56454435 T/G cg25039879 chr17:56429692 SUPT4H1 -0.44 -6.0 -0.35 6.39e-9 Intelligence (multi-trait analysis); CESC cis rs727505 0.954 rs7789055 chr7:124677543 G/T cg23710748 chr7:124431027 NA -0.41 -6.39 -0.37 7.48e-10 Lewy body disease; CESC cis rs858239 0.899 rs858271 chr7:23278283 G/T cg23682824 chr7:23144976 KLHL7 0.42 5.49 0.32 9.35e-8 Cerebrospinal fluid biomarker levels; CESC cis rs6977660 0.598 rs72591445 chr7:19773035 G/A cg05791153 chr7:19748676 TWISTNB 0.76 6.82 0.39 6.28e-11 Thyroid stimulating hormone; CESC cis rs36051895 0.625 rs12340344 chr9:5176281 C/A cg02405213 chr9:5042618 JAK2 -0.55 -6.83 -0.39 5.68e-11 Pediatric autoimmune diseases; CESC cis rs7937682 0.889 rs11213971 chr11:111529829 A/G cg22437258 chr11:111473054 SIK2 0.69 9.25 0.49 7.9e-18 Primary sclerosing cholangitis; CESC cis rs2011503 1.000 rs4808968 chr19:19644402 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg02487422 chr3:49467188 NICN1 0.38 5.3 0.31 2.42e-7 Menarche (age at onset); CESC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg07308232 chr7:1071921 C7orf50 -0.51 -7.16 -0.4 7.72e-12 Longevity;Endometriosis; CESC cis rs35306767 0.909 rs12264390 chr10:959111 T/C cg10556349 chr10:835070 NA 0.49 5.24 0.31 3.33e-7 Eosinophil percentage of granulocytes; CESC cis rs950169 1.000 rs34751999 chr15:84758419 T/C cg17507749 chr15:85114479 UBE2QP1 0.64 7.11 0.4 1.11e-11 Schizophrenia; CESC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.94 14.0 0.65 1.02e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg00149659 chr3:10157352 C3orf10 0.67 7.8 0.43 1.45e-13 Alzheimer's disease; CESC cis rs67478160 0.619 rs3742365 chr14:104198251 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.39 -0.41 1.94e-12 Schizophrenia; CESC cis rs12325245 0.536 rs12931051 chr16:58626534 C/T cg01152986 chr16:58549298 SETD6 0.86 5.07 0.3 7.48e-7 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06320606 chr5:60139941 ELOVL7 -0.46 -6.04 -0.35 5.28e-9 Ulcerative colitis; CESC cis rs7095944 0.644 rs4962694 chr10:126436717 G/T cg08799069 chr10:126477246 METTL10 -0.37 -5.29 -0.31 2.58e-7 Asthma; CESC cis rs6997458 0.742 rs6988475 chr8:86383268 A/G cg21346043 chr8:86351067 CA3 -0.34 -5.11 -0.3 6.28e-7 Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7089973 0.604 rs11196943 chr10:116598865 T/C cg23260525 chr10:116636907 FAM160B1 0.4 7.38 0.41 2.03e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -6.7 -0.38 1.27e-10 Menopause (age at onset); CESC cis rs6088590 1.000 rs6120750 chr20:33465289 A/C cg08999081 chr20:33150536 PIGU 0.57 8.42 0.46 2.34e-15 Coronary artery disease; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg02233558 chr5:127418922 SLC12A2;FLJ33630 0.48 6.29 0.36 1.28e-9 Weight; CESC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg15147215 chr3:52552868 STAB1 -0.31 -5.26 -0.31 2.96e-7 Electroencephalogram traits; CESC cis rs7188697 0.922 rs8047769 chr16:58591987 G/A cg21335942 chr16:58549945 SETD6 -0.45 -5.28 -0.31 2.69e-7 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11645754 chr17:21188174 MAP2K3 0.53 6.32 0.36 1.11e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.965 rs2854154 chr17:61981696 C/A cg26338869 chr17:61819248 STRADA -0.64 -8.12 -0.45 1.72e-14 Prudent dietary pattern; CESC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.35 -0.57 1.31e-24 Type 2 diabetes; CESC cis rs13034020 0.522 rs4564760 chr2:61248575 T/C cg18625361 chr2:61244694 PEX13;PUS10 0.65 6.33 0.36 1.04e-9 Hodgkin's lymphoma; CESC cis rs1707322 0.650 rs4660879 chr1:46105401 C/A cg05343316 chr1:45956843 TESK2 0.5 6.34 0.36 9.93e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg01592312 chr17:79658424 HGS 0.51 7.1 0.4 1.17e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs35955747 0.869 rs131219 chr22:31760250 T/C cg25791279 chr22:32026902 PISD 0.46 5.66 0.33 3.95e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs7833986 0.501 rs2719255 chr8:57036658 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 7e-13 Height; CESC cis rs2204008 0.715 rs12815986 chr12:38343869 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.64 0.38 1.78e-10 Bladder cancer; CESC cis rs11030122 0.673 rs10835474 chr11:4020819 G/T cg18678763 chr11:4115507 RRM1 -0.49 -6.59 -0.38 2.37e-10 Mean platelet volume;Platelet distribution width; CESC cis rs6032067 1.000 rs2233896 chr20:43850400 C/A cg10761708 chr20:43804764 PI3 0.52 6.22 0.36 1.92e-9 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19491415 chr10:32217948 ARHGAP12 0.54 6.65 0.38 1.62e-10 Gut microbiome composition (summer); CESC trans rs8073060 0.586 rs4796101 chr17:33998593 C/T cg19694781 chr19:47549865 TMEM160 -0.74 -7.25 -0.41 4.47e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs4604732 0.589 rs78689516 chr1:247626274 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2549003 0.966 rs10065633 chr5:131816716 T/C cg00255919 chr5:131827918 IRF1 0.51 8.59 0.47 7.76e-16 Asthma (sex interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26635474 chr16:1706710 CRAMP1L 0.43 6.51 0.37 3.82e-10 Fibrinogen levels; CESC cis rs9287719 0.967 rs7582775 chr2:10738449 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs9814567 0.752 rs13075117 chr3:134329535 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.43 5.6 0.33 5.39e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9549367 0.865 rs3861721 chr13:113906308 C/T cg00898013 chr13:113819073 PROZ -0.53 -7.21 -0.41 5.74e-12 Platelet distribution width; CESC cis rs7582720 0.945 rs114604411 chr2:203811912 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs11958404 0.860 rs72818116 chr5:157440616 G/T cg05962755 chr5:157440814 NA 0.59 6.52 0.37 3.45e-10 IgG glycosylation; CESC cis rs1707322 1.000 rs785469 chr1:46521091 C/T cg05343316 chr1:45956843 TESK2 -0.44 -5.44 -0.32 1.2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs599083 0.573 rs3018713 chr11:68390986 A/G cg01657329 chr11:68192670 LRP5 -0.47 -6.12 -0.35 3.39e-9 Bone mineral density (spine); CESC cis rs6547741 1.000 rs6737921 chr2:27839107 T/C cg27432699 chr2:27873401 GPN1 0.49 6.91 0.39 3.56e-11 Oral cavity cancer; CESC cis rs9399137 0.561 rs11753985 chr6:135280438 C/T cg24558204 chr6:135376177 HBS1L 0.71 9.63 0.51 5.17e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22777309 chr6:35182216 SCUBE3 0.62 7.12 0.4 9.89e-12 Gut microbiome composition (summer); CESC cis rs12545109 0.571 rs7002482 chr8:57295200 C/T cg09654669 chr8:57350985 NA -0.49 -5.95 -0.34 8.29e-9 Obesity-related traits; CESC cis rs73206853 0.841 rs111612251 chr12:111017607 T/C cg12870014 chr12:110450643 ANKRD13A 0.7 6.18 0.36 2.38e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs10838687 0.736 rs4647725 chr11:47245389 T/C cg25783544 chr11:47291846 MADD 0.57 6.54 0.37 3.15e-10 Proinsulin levels; CESC cis rs7116495 0.609 rs10501408 chr11:71680590 C/T cg07596299 chr11:71824057 C11orf51 -0.88 -5.07 -0.3 7.53e-7 Severe influenza A (H1N1) infection; CESC trans rs2727020 0.615 rs4980435 chr11:49591576 G/A cg03929089 chr4:120376271 NA -0.85 -13.48 -0.64 6.81e-32 Coronary artery disease; CESC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7336332 0.598 rs74563672 chr13:28010660 A/G cg22138327 chr13:27999177 GTF3A 0.62 5.82 0.34 1.71e-8 Weight; CESC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.33 0.41 2.84e-12 Tonsillectomy; CESC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg00149659 chr3:10157352 C3orf10 -0.52 -6.75 -0.38 9.49e-11 Alzheimer's disease; CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.51 -0.32 8.46e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2235544 0.542 rs679801 chr1:54470757 T/C cg25741118 chr1:54482237 LDLRAD1 0.24 5.76 0.33 2.29e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg07507251 chr3:52567010 NT5DC2 0.34 5.8 0.34 1.85e-8 Electroencephalogram traits; CESC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.68 -9.11 -0.49 2.14e-17 Mean platelet volume; CESC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.41 0.64 1.22e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg23978390 chr7:1156363 C7orf50 0.57 8.29 0.45 5.56e-15 Longevity;Endometriosis; CESC cis rs151234 0.741 rs10521145 chr16:28596884 A/G cg01378222 chr16:28622494 SULT1A1 0.57 7.55 0.42 6.92e-13 Platelet distribution width; CESC cis rs362296 0.661 rs3095079 chr4:3265414 A/G cg08886695 chr4:3369023 RGS12 -0.4 -5.45 -0.32 1.16e-7 Parental longevity (mother's age at death); CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg24669728 chr1:41445888 CTPS -0.5 -6.12 -0.35 3.37e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC trans rs61931739 0.577 rs7313428 chr12:33672325 T/C cg26384229 chr12:38710491 ALG10B -0.46 -6.54 -0.37 3.07e-10 Morning vs. evening chronotype; CESC cis rs561341 0.602 rs114562703 chr17:30233899 G/T cg13647721 chr17:30228624 UTP6 0.8 9.63 0.51 5.09e-19 Hip circumference adjusted for BMI; CESC cis rs7786808 0.741 rs62479982 chr7:158227546 A/G cg09998033 chr7:158218633 PTPRN2 -0.44 -6.59 -0.38 2.33e-10 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10207181 chr1:147801090 NA -0.44 -6.1 -0.35 3.67e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00577569 chr7:66093764 KCTD7 0.54 6.22 0.36 1.91e-9 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs17232630 chr16:89851179 C/T cg00800038 chr16:89945340 TCF25 -0.91 -7.52 -0.42 8.29e-13 Skin colour saturation; CESC cis rs7818345 0.967 rs4433156 chr8:19284247 A/C cg11303988 chr8:19266685 CSGALNACT1 0.33 5.96 0.34 8.14e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg11764359 chr7:65958608 NA -0.7 -9.2 -0.49 1.14e-17 Aortic root size; CESC cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg24308560 chr3:49941425 MST1R -0.64 -9.34 -0.5 3.96e-18 Intelligence (multi-trait analysis); CESC cis rs9916302 0.904 rs2338797 chr17:37548241 G/A cg07936489 chr17:37558343 FBXL20 0.8 11.64 0.58 1.44e-25 Glomerular filtration rate (creatinine); CESC cis rs2072732 0.861 rs12567620 chr1:2956999 T/G cg03976712 chr1:2946727 NA 0.33 5.52 0.32 8.2e-8 Plateletcrit; CESC cis rs3892630 0.588 rs2287881 chr19:33333155 A/G cg22980127 chr19:33182716 NUDT19 -1.03 -13.41 -0.64 1.21e-31 Red blood cell traits; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02446366 chr6:41514112 FOXP4 -0.51 -6.46 -0.37 4.95e-10 Ulcerative colitis; CESC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.22 0.41 5.62e-12 Height; CESC cis rs4919087 0.810 rs10786321 chr10:99026112 T/C cg25902810 chr10:99078978 FRAT1 0.65 9.18 0.49 1.3e-17 Monocyte count; CESC trans rs79976124 0.879 rs78012385 chr6:66618091 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 8.59 0.47 7.54e-16 Type 2 diabetes; CESC cis rs6493487 0.512 rs1904432 chr15:51249851 G/T cg02338191 chr15:51200825 AP4E1 0.63 5.86 0.34 1.39e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg23281280 chr6:28129359 ZNF389 0.49 6.52 0.37 3.55e-10 Parkinson's disease; CESC cis rs36051895 0.659 rs10815150 chr9:5067301 C/A cg02405213 chr9:5042618 JAK2 -0.48 -5.93 -0.34 9.18e-9 Pediatric autoimmune diseases; CESC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg27532560 chr4:187881888 NA -0.38 -5.91 -0.34 1.03e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg08859206 chr1:53392774 SCP2 0.55 7.23 0.41 5.1e-12 Monocyte count; CESC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.58 0.55 4.6e-22 Prudent dietary pattern; CESC cis rs703842 0.616 rs4760332 chr12:58222672 A/C cg04478727 chr12:58166393 METTL1;FAM119B -0.56 -6.54 -0.37 3.22e-10 Multiple sclerosis; CESC trans rs11039798 0.512 rs3974936 chr11:49005012 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.91 0.39 3.58e-11 Axial length; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg11062677 chr19:13976917 NA -0.46 -6.06 -0.35 4.62e-9 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14086791 chr11:69489770 ORAOV1 -0.44 -6.57 -0.37 2.72e-10 Gambling; CESC cis rs6460942 0.545 rs17448114 chr7:12524458 G/C cg10578991 chr7:12443926 VWDE -0.49 -5.13 -0.3 5.63e-7 Coronary artery disease; CESC trans rs17307778 0.808 rs10767361 chr11:25357543 C/T cg22888484 chr20:37075185 SNHG11 -0.63 -6.06 -0.35 4.53e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2439831 0.702 rs9989313 chr15:44152817 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.43 0.42 1.45e-12 Lung cancer in ever smokers; CESC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg01238044 chr22:24384105 GSTT1 0.5 6.45 0.37 5.2400000000000005e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7219021 0.926 rs9912856 chr17:46861667 C/T cg16584676 chr17:46985605 UBE2Z -0.56 -6.44 -0.37 5.45e-10 Schizophrenia or bipolar disorder; CESC cis rs12618769 0.652 rs72821965 chr2:99188783 T/C cg10123293 chr2:99228465 UNC50 0.41 5.34 0.31 2e-7 Bipolar disorder; CESC cis rs5758659 0.714 rs7245 chr22:42481849 G/A cg00645731 chr22:42541494 CYP2D7P1 0.33 5.52 0.32 7.9e-8 Cognitive function; CESC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg22823121 chr1:150693482 HORMAD1 0.39 5.43 0.32 1.26e-7 Melanoma; CESC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg12963246 chr6:28129442 ZNF389 0.49 6.09 0.35 3.94e-9 Parkinson's disease; CESC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.3 0.36 1.21e-9 Menopause (age at onset); CESC cis rs5758659 1.000 rs5758660 chr22:42623718 C/A cg05082376 chr22:42548792 NA -0.37 -5.43 -0.32 1.28e-7 Cognitive function; CESC cis rs826838 0.967 rs11169387 chr12:39145737 C/T cg13010199 chr12:38710504 ALG10B 0.57 7.99 0.44 4.1e-14 Heart rate; CESC cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.89 0.48 9.9e-17 Colonoscopy-negative controls vs population controls; CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg07092213 chr7:1199455 ZFAND2A -0.44 -5.91 -0.34 1.03e-8 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07516076 chr7:64197245 NA -0.62 -7.31 -0.41 3.25e-12 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21695485 chr11:66824219 RHOD -0.51 -6.92 -0.39 3.32e-11 Fibrinogen levels; CESC trans rs61931739 0.517 rs11611190 chr12:34015697 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.24 0.45 8.19e-15 Morning vs. evening chronotype; CESC cis rs9372253 0.678 rs9487392 chr6:110708626 C/T cg19196401 chr6:110721138 DDO 0.41 5.81 0.34 1.78e-8 Platelet distribution width; CESC cis rs807669 0.835 rs1780639 chr22:19174603 T/C cg02655711 chr22:19163373 SLC25A1 0.96 14.54 0.67 1.32e-35 Metabolite levels; CESC trans rs11250098 0.547 rs2409764 chr8:11281273 C/T cg15556689 chr8:8085844 FLJ10661 0.53 6.3 0.36 1.23e-9 Morning vs. evening chronotype; CESC cis rs7084402 0.967 rs1427222 chr10:60290970 A/G cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.31e-18 Refractive error; CESC trans rs2623325 0.874 rs1481543 chr3:99113531 G/A cg19595760 chr1:25948511 MAN1C1 -0.48 -6.41 -0.37 6.61e-10 Optic cup area;Vertical cup-disc ratio; CESC cis rs6577655 0.517 rs11998030 chr8:135585325 C/T cg17885191 chr8:135476712 NA 0.45 5.08 0.3 7.18e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs61931739 0.500 rs11053268 chr12:34545121 T/C cg06521331 chr12:34319734 NA -0.36 -5.03 -0.3 9.01e-7 Morning vs. evening chronotype; CESC cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg21573476 chr21:45109991 RRP1B -0.51 -7.18 -0.4 7.23e-12 Mean corpuscular volume; CESC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg06873352 chr17:61820015 STRADA 0.72 12.8 0.62 1.61e-29 Prudent dietary pattern; CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg18404041 chr3:52824283 ITIH1 -0.36 -6.38 -0.36 7.86e-10 Electroencephalogram traits; CESC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg04414720 chr1:150670196 GOLPH3L 0.63 9.04 0.49 3.47e-17 Tonsillectomy; CESC trans rs2415984 0.846 rs10146746 chr14:46853609 C/G cg14945696 chr3:52713679 PBRM1 -0.4 -6.03 -0.35 5.55e-9 Number of children ever born; CESC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg22920501 chr2:26401640 FAM59B -0.65 -7.85 -0.43 1.06e-13 Gut microbiome composition (summer); CESC cis rs5753618 0.561 rs737887 chr22:31696615 A/G cg00478049 chr22:31556069 RNF185 0.45 5.09 0.3 6.87e-7 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04521409 chr20:34287082 ROMO1;NFS1 0.56 6.46 0.37 5.05e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.592 rs4822040 chr22:41963553 C/G cg17376030 chr22:41985996 PMM1 0.52 5.83 0.34 1.61e-8 Vitiligo; CESC cis rs7208859 0.623 rs216439 chr17:28927884 T/C cg19761014 chr17:28927070 LRRC37B2 0.85 6.59 0.38 2.33e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7086627 0.515 rs10887905 chr10:82210855 A/T cg00277334 chr10:82204260 NA -0.91 -16.25 -0.71 1.13e-41 Post bronchodilator FEV1; CESC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.72 0.33 2.87e-8 Menopause (age at onset); CESC cis rs17292804 0.527 rs12887734 chr14:104046834 G/T cg24130564 chr14:104152367 KLC1 -0.47 -5.86 -0.34 1.39e-8 Autism spectrum disorder or schizophrenia; CESC cis rs7834588 0.523 rs4645553 chr8:63835295 A/G cg20602954 chr8:63776762 NKAIN3 0.3 5.08 0.3 7.18e-7 Response to Vitamin E supplementation; CESC cis rs9303280 0.773 rs11078925 chr17:38025208 T/C cg19468946 chr17:37922297 IKZF3 -0.41 -5.42 -0.32 1.34e-7 Self-reported allergy; CESC cis rs4746818 1.000 rs7091695 chr10:70964997 A/G cg11621586 chr10:70884670 VPS26A -0.86 -8.54 -0.46 1.04e-15 Left atrial antero-posterior diameter; CESC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg04267008 chr7:1944627 MAD1L1 -0.67 -8.45 -0.46 1.93e-15 Bipolar disorder and schizophrenia; CESC cis rs9399135 0.967 rs4895439 chr6:135318854 A/T cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08928321 chr10:70748447 KIAA1279 0.46 6.81 0.39 6.61e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs244293 0.701 rs4793784 chr17:53038430 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.45 -6.14 -0.35 3.02e-9 Menarche (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11248668 chr11:45826493 SLC35C1 -0.47 -6.56 -0.37 2.88e-10 Gambling; CESC cis rs7589342 0.862 rs10469862 chr2:106509907 C/T cg16077055 chr2:106428750 NCK2 0.41 5.72 0.33 2.86e-8 Addiction; CESC cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg24690094 chr11:67383802 NA -0.38 -6.26 -0.36 1.56e-9 Mean corpuscular volume; CESC cis rs7680126 0.500 rs4640669 chr4:10145733 A/G cg11266682 chr4:10021025 SLC2A9 0.48 6.48 0.37 4.55e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs56399783 0.901 rs73049341 chr7:2812255 G/C cg19731401 chr7:2775893 GNA12 0.65 5.87 0.34 1.32e-8 Childhood ear infection; CESC cis rs1801251 1.000 rs11679079 chr2:233612656 C/T cg08000102 chr2:233561755 GIGYF2 0.66 9.34 0.5 4.05e-18 Coronary artery disease; CESC cis rs7208859 0.673 rs9899525 chr17:29120296 T/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs854765 0.583 rs4925130 chr17:17807858 G/A cg04398451 chr17:18023971 MYO15A -0.64 -8.85 -0.48 1.23e-16 Total body bone mineral density; CESC cis rs1215050 0.765 rs6852699 chr4:98767505 T/C cg05340658 chr4:99064831 C4orf37 0.53 6.85 0.39 5.29e-11 Waist-to-hip ratio adjusted for body mass index; CESC trans rs9399401 1.000 rs1040525 chr6:142703669 C/T cg23543539 chr11:125461746 STT3A -0.43 -6.06 -0.35 4.66e-9 Chronic obstructive pulmonary disease; CESC cis rs7208859 0.623 rs9911997 chr17:29124648 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9457247 1.000 rs430477 chr6:167389851 T/C cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg22834771 chr12:69754056 YEATS4 -0.56 -7.63 -0.42 4.19e-13 Cerebrospinal fluid biomarker levels; CESC cis rs2109514 0.765 rs28494601 chr7:116101261 A/C cg12739419 chr7:116140593 CAV2 -0.32 -5.7 -0.33 3.11e-8 Prevalent atrial fibrillation; CESC cis rs6570726 0.935 rs382910 chr6:145865941 G/A cg23711669 chr6:146136114 FBXO30 0.79 11.47 0.58 5.24e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs2933343 0.700 rs789233 chr3:128603150 G/T cg25356066 chr3:128598488 ACAD9 0.64 9.08 0.49 2.52e-17 IgG glycosylation; CESC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg00166722 chr3:10149974 C3orf24 -0.47 -6.15 -0.35 2.81e-9 Alzheimer's disease; CESC cis rs2404602 0.692 rs59088060 chr15:76859974 T/C cg22467129 chr15:76604101 ETFA -0.35 -5.24 -0.31 3.24e-7 Blood metabolite levels; CESC trans rs79976124 0.879 rs17511467 chr6:66627293 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.74 8.48 0.46 1.58e-15 Type 2 diabetes; CESC cis rs1008375 0.863 rs7680984 chr4:17600884 A/G cg16339924 chr4:17578868 LAP3 0.68 8.78 0.47 2.03e-16 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs5769707 0.935 rs1109320 chr22:49989106 G/A cg05373962 chr22:49881684 NA -0.36 -6.24 -0.36 1.69e-9 Monocyte count;Monocyte percentage of white cells; CESC cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg08564027 chr20:61660810 NA 0.9 15.26 0.68 3.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs9916302 0.653 rs4239223 chr17:37717004 T/C cg20243544 chr17:37824526 PNMT 0.53 5.26 0.31 3.03e-7 Glomerular filtration rate (creatinine); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg19354750 chr17:61554413 ACE 0.4 6.01 0.35 6.21e-9 Vertical cup-disc ratio; CESC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.75 -0.33 2.49e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs72781680 0.611 rs72781695 chr2:24266744 T/C cg08917208 chr2:24149416 ATAD2B 0.63 6.09 0.35 3.87e-9 Lymphocyte counts; CESC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg00908189 chr16:619842 PIGQ 0.64 8.99 0.48 4.69e-17 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20831041 chr11:464554 PTDSS2 -0.58 -6.48 -0.37 4.35e-10 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg25427524 chr10:38739819 LOC399744 -0.68 -9.8 -0.52 1.54e-19 Extrinsic epigenetic age acceleration; CESC cis rs6723226 0.521 rs1991626 chr2:32602450 G/A cg02381751 chr2:32503542 YIPF4 -0.5 -6.55 -0.37 3.01e-10 Intelligence (multi-trait analysis); CESC cis rs1879734 0.636 rs12025857 chr1:54175360 C/T cg23596471 chr1:54105337 GLIS1 0.32 5.17 0.3 4.7e-7 Mitral valve prolapse; CESC cis rs6088580 0.634 rs6059829 chr20:33017074 G/A cg24642439 chr20:33292090 TP53INP2 0.52 6.79 0.39 7.18e-11 Glomerular filtration rate (creatinine); CESC cis rs722599 0.683 rs10139016 chr14:75274288 T/C cg11812906 chr14:75593930 NEK9 0.44 5.26 0.31 2.91e-7 IgG glycosylation; CESC cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg25019033 chr10:957182 NA -0.62 -6.76 -0.38 8.97e-11 Eosinophil percentage of granulocytes; CESC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg06634786 chr22:41940651 POLR3H -0.72 -7.52 -0.42 8.35e-13 Vitiligo; CESC cis rs10129255 0.957 rs8009638 chr14:107185809 G/A cg07958169 chr14:107095056 NA -0.44 -6.01 -0.35 6.17e-9 Kawasaki disease; CESC cis rs7666738 0.800 rs12163918 chr4:98835794 T/C cg05340658 chr4:99064831 C4orf37 0.7 9.83 0.52 1.17e-19 Colonoscopy-negative controls vs population controls; CESC cis rs1865721 0.804 rs59187673 chr18:73143964 A/G cg26385618 chr18:73139727 C18orf62 -0.52 -8.31 -0.45 5.15e-15 Intelligence; CESC cis rs2180341 1.000 rs9401950 chr6:127655485 C/T cg27446573 chr6:127587934 RNF146 1.09 16.35 0.71 5.12e-42 Breast cancer; CESC cis rs11920090 0.720 rs60354090 chr3:170740217 C/T cg09710316 chr3:170744871 SLC2A2 0.51 5.99 0.35 6.67e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs897984 0.646 rs9938088 chr16:30830004 G/A cg02466173 chr16:30829666 NA -0.6 -11.58 -0.58 2.23e-25 Dementia with Lewy bodies; CESC cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg24531977 chr5:56204891 C5orf35 0.7 9.44 0.5 2.05e-18 Initial pursuit acceleration; CESC cis rs2880765 0.743 rs7168345 chr15:86013601 A/G cg10818794 chr15:86012489 AKAP13 0.33 5.12 0.3 5.8e-7 Coronary artery disease; CESC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg11494091 chr17:61959527 GH2 0.71 12.02 0.59 7.32e-27 Prudent dietary pattern; CESC cis rs10089 0.953 rs758179 chr5:127354424 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 9.94 0.52 5.36e-20 Ileal carcinoids; CESC cis rs208520 0.690 rs864314 chr6:66814830 G/A cg07460842 chr6:66804631 NA -1.11 -27.03 -0.86 3.9e-78 Exhaled nitric oxide output; CESC cis rs7617773 0.817 rs6794644 chr3:48330037 T/C cg11946769 chr3:48343235 NME6 0.81 10.91 0.56 3.86e-23 Coronary artery disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03399598 chr4:174091002 GALNT7 0.46 6.34 0.36 9.93e-10 Systemic lupus erythematosus; CESC cis rs2637266 0.703 rs846589 chr10:78491742 A/G cg18941641 chr10:78392320 NA 0.37 7.19 0.4 6.47e-12 Pulmonary function; CESC cis rs9911578 0.967 rs4132925 chr17:56938016 C/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.26 -0.31 2.94e-7 Intelligence (multi-trait analysis); CESC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg22920501 chr2:26401640 FAM59B -0.79 -9.3 -0.5 5.61e-18 Gut microbiome composition (summer); CESC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg19046167 chr17:80928561 B3GNTL1 -0.41 -5.03 -0.3 8.9e-7 Breast cancer; CESC cis rs4722166 0.604 rs2390715 chr7:22783878 A/C cg05265849 chr7:22767390 IL6 0.57 7.07 0.4 1.4e-11 Lung cancer; CESC cis rs2573652 0.722 rs11636047 chr15:100543341 A/G cg09918751 chr15:100517450 ADAMTS17 -0.31 -5.82 -0.34 1.69e-8 Height; CESC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg21770322 chr7:97807741 LMTK2 0.55 8.25 0.45 7.24e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs4423214 0.840 rs1540127 chr11:71179038 G/A cg05163923 chr11:71159392 DHCR7 -0.65 -7.55 -0.42 6.91e-13 Vitamin D levels; CESC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg22800045 chr5:56110881 MAP3K1 0.81 9.74 0.51 2.35e-19 Initial pursuit acceleration; CESC cis rs3820068 0.603 rs56032936 chr1:15970953 T/C cg17385448 chr1:15911702 AGMAT 0.42 6.75 0.38 9.26e-11 Systolic blood pressure; CESC trans rs11264799 0.765 rs12128597 chr1:157623603 C/T cg22691776 chr3:15032403 NR2C2 0.33 6.1 0.35 3.7e-9 IgA nephropathy; CESC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg22433210 chr17:43662623 NA 0.58 7.49 0.42 1.01e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6963495 0.818 rs6973974 chr7:105170629 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.5 -0.32 9.1e-8 Bipolar disorder (body mass index interaction); CESC cis rs7772486 0.875 rs6934467 chr6:146410529 G/T cg23711669 chr6:146136114 FBXO30 0.88 12.95 0.62 4.95e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.867 rs13227219 chr7:65844062 T/A cg18876405 chr7:65276391 NA 0.48 6.23 0.36 1.79e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00355673 chr14:92573075 ATXN3 0.52 6.52 0.37 3.56e-10 Gut microbiome composition (summer); CESC cis rs3126085 0.877 rs6662450 chr1:152191709 C/G cg26876637 chr1:152193138 HRNR 0.47 5.43 0.32 1.28e-7 Atopic dermatitis; CESC trans rs61931739 0.500 rs34107854 chr12:34482333 C/A cg26384229 chr12:38710491 ALG10B 0.7 10.6 0.55 4.1e-22 Morning vs. evening chronotype; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg03637622 chr5:179334771 TBC1D9B -0.42 -6.3 -0.36 1.21e-9 Vertical cup-disc ratio; CESC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg20151795 chr6:28129481 ZNF389 0.45 5.92 0.34 9.77e-9 Depression; CESC cis rs5167 0.504 rs8100120 chr19:45466058 T/C cg20090143 chr19:45452003 APOC2 0.35 6.01 0.35 6.06e-9 Blood protein levels; CESC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg15921436 chr17:44337874 NA 0.42 5.36 0.31 1.85e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4595586 1.000 rs1403521 chr12:39232007 A/G cg26384229 chr12:38710491 ALG10B 0.38 5.28 0.31 2.69e-7 Morning vs. evening chronotype; CESC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.79 9.31 0.5 5.04e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs7104764 0.507 rs6598054 chr11:254010 C/T cg19998151 chr11:267613 NA 0.42 5.17 0.3 4.52e-7 Menarche (age at onset); CESC cis rs1499972 0.529 rs1499982 chr3:117820386 C/T cg07612923 chr3:117604196 NA -0.66 -5.59 -0.33 5.51e-8 Schizophrenia; CESC trans rs8073060 0.586 rs225286 chr17:33930458 G/A cg19694781 chr19:47549865 TMEM160 -0.73 -7.05 -0.4 1.52e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs8077577 0.895 rs16960986 chr17:18108562 A/G cg16794390 chr17:18148240 FLII -0.43 -5.65 -0.33 4.11e-8 Obesity-related traits; CESC cis rs7635838 0.963 rs7627171 chr3:11413429 G/C cg00170343 chr3:11313890 ATG7 0.41 5.47 0.32 1.05e-7 HDL cholesterol; CESC cis rs1215050 0.791 rs9993992 chr4:98810851 C/G cg05340658 chr4:99064831 C4orf37 0.52 6.83 0.39 5.72e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9715521 0.935 rs6818912 chr4:59834738 A/G cg11281224 chr4:60001000 NA -0.52 -6.9 -0.39 3.76e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3540 0.557 rs11634314 chr15:91042066 A/C cg10434728 chr15:90938212 IQGAP1 -0.41 -7.27 -0.41 3.94e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg24829409 chr8:58192753 C8orf71 -0.51 -6.64 -0.38 1.72e-10 Developmental language disorder (linguistic errors); CESC cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg11663144 chr21:46675770 NA -0.62 -9.45 -0.5 1.88e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -6.99 -0.39 2.2e-11 Menopause (age at onset); CESC cis rs12579753 0.789 rs35448307 chr12:82165817 A/G cg24719984 chr12:82153464 PPFIA2 -0.37 -5.35 -0.31 1.9e-7 Resting heart rate; CESC cis rs10751667 0.961 rs7480178 chr11:927108 T/C cg20946044 chr11:1010712 AP2A2 -0.43 -5.63 -0.33 4.57e-8 Alzheimer's disease (late onset); CESC cis rs67311347 1.000 rs11914297 chr3:40410070 T/C cg24209194 chr3:40518798 ZNF619 0.43 5.36 0.31 1.78e-7 Renal cell carcinoma; CESC cis rs9522267 0.535 rs9515447 chr13:112222303 C/T cg10483660 chr13:112241077 NA -0.33 -5.79 -0.34 1.98e-8 Hepatitis; CESC cis rs3859192 0.599 rs12451897 chr17:38179275 G/T cg17344932 chr17:38183730 MED24;SNORD124 0.63 9.61 0.51 6.04e-19 White blood cell count; CESC cis rs1801251 1.000 rs12478564 chr2:233598340 C/T cg08000102 chr2:233561755 GIGYF2 0.67 9.4 0.5 2.59e-18 Coronary artery disease; CESC cis rs8002861 0.905 rs12875768 chr13:44428305 C/T cg14210620 chr13:44453864 C13orf31;CCDC122 -0.42 -5.21 -0.3 3.75e-7 Leprosy; CESC cis rs17376456 0.877 rs7736620 chr5:93305762 C/T cg25358565 chr5:93447407 FAM172A 1.07 10.7 0.55 1.86e-22 Diabetic retinopathy; CESC cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg20307385 chr11:47447363 PSMC3 -0.59 -7.05 -0.4 1.56e-11 Subjective well-being; CESC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg19622623 chr12:86230825 RASSF9 -0.44 -5.36 -0.31 1.81e-7 Major depressive disorder; CESC trans rs3942852 0.955 rs1503190 chr11:48117873 A/G cg15704280 chr7:45808275 SEPT13 -0.59 -6.83 -0.39 5.9e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs10129255 0.912 rs67410411 chr14:107136341 G/A cg23076370 chr14:107095027 NA -0.41 -5.15 -0.3 5.19e-7 Kawasaki disease; CESC cis rs4132509 0.793 rs12037013 chr1:243784207 G/A cg21452805 chr1:244014465 NA 0.64 6.69 0.38 1.3e-10 RR interval (heart rate); CESC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg24829409 chr8:58192753 C8orf71 -0.75 -9.78 -0.51 1.74e-19 Developmental language disorder (linguistic errors); CESC cis rs3617 0.625 rs3774364 chr3:52863605 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.36 5.16 0.3 4.89e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs4704187 0.574 rs4704184 chr5:74471677 A/G cg03227963 chr5:74354835 NA 0.28 5.15 0.3 5e-7 Response to amphetamines; CESC trans rs2018683 0.899 rs10269454 chr7:28978400 C/T cg19402173 chr7:128379420 CALU -0.58 -7.79 -0.43 1.56e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05707844 chr2:37383994 EIF2AK2 0.64 7.37 0.41 2.24e-12 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs8013831 chr14:56172898 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.69 5.94 0.34 8.99e-9 Putamen volume; CESC trans rs35110281 0.517 rs11089020 chr21:44939991 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 7.03 0.4 1.72e-11 Mean corpuscular volume; CESC cis rs2880765 0.631 rs55767890 chr15:86004142 C/G cg19183879 chr15:85880815 NA -0.31 -5.93 -0.34 9.57e-9 Coronary artery disease; CESC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.01 0.4 2e-11 Bipolar disorder; CESC cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs17818399 0.547 rs4952833 chr2:46762034 T/C cg02822958 chr2:46747628 ATP6V1E2 0.44 5.11 0.3 6.1e-7 Height; CESC cis rs2933343 0.700 rs883602 chr3:128653952 A/G cg24203234 chr3:128598194 ACAD9 0.44 6.01 0.35 5.99e-9 IgG glycosylation; CESC cis rs4822044 0.568 rs1883370 chr22:42143740 C/A cg17376030 chr22:41985996 PMM1 -0.75 -7.85 -0.43 1.06e-13 Cannabis dependence symptom count; CESC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 5.44 0.32 1.23e-7 Tonsillectomy; CESC cis rs2276314 1.000 rs9304154 chr18:33562227 C/T cg05985134 chr18:33552581 C18orf21 0.63 7.17 0.4 7.56e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs1950626 0.662 rs72700538 chr14:101441911 C/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.83 11.29 0.57 2.14e-24 Pelvic organ prolapse (moderate/severe); CESC cis rs9896933 0.887 rs78483419 chr17:80870884 T/C cg19500275 chr17:80737654 TBCD 0.67 6.29 0.36 1.28e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs16910800 0.731 rs16910759 chr11:23192131 C/G cg20040320 chr11:23191996 NA -0.67 -6.56 -0.37 2.77e-10 Cancer; CESC cis rs11098499 0.575 rs9996586 chr4:120326942 A/G cg09307838 chr4:120376055 NA 0.52 7.01 0.4 1.95e-11 Corneal astigmatism; CESC cis rs67478160 0.619 rs10083370 chr14:104314182 G/A cg08213375 chr14:104286397 PPP1R13B -0.54 -10.67 -0.55 2.33e-22 Schizophrenia; CESC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg12516959 chr21:47718080 NA 0.41 5.97 0.34 7.7e-9 Testicular germ cell tumor; CESC cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg02079420 chr8:82753780 SNX16 0.54 8.28 0.45 6.23e-15 Diastolic blood pressure; CESC cis rs258892 0.895 rs9293442 chr5:72055595 T/C cg21869765 chr5:72125136 TNPO1 -0.42 -5.32 -0.31 2.2e-7 Small cell lung carcinoma; CESC trans rs61931739 0.534 rs10506120 chr12:34235603 G/A cg26384229 chr12:38710491 ALG10B 0.63 9.17 0.49 1.41e-17 Morning vs. evening chronotype; CESC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg00945038 chr17:61921165 SMARCD2 -0.36 -5.13 -0.3 5.71e-7 Prudent dietary pattern; CESC cis rs1538970 0.816 rs3790583 chr1:45956828 C/G cg05343316 chr1:45956843 TESK2 0.93 12.78 0.62 1.91e-29 Platelet count; CESC trans rs6794880 0.778 rs80331882 chr3:84420289 C/G cg03554283 chr8:76319451 NA 0.57 6.07 0.35 4.44e-9 Body mass index (joint analysis main effects and smoking interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs9372253 1.000 rs2235989 chr6:110714584 A/T cg19196401 chr6:110721138 DDO -0.37 -5.38 -0.31 1.68e-7 Platelet distribution width; CESC cis rs360798 0.512 rs9973612 chr2:63019815 G/C cg17519650 chr2:63277830 OTX1 -0.58 -7.62 -0.42 4.62e-13 Coronary artery disease; CESC cis rs617791 0.508 rs10896074 chr11:65776304 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.51 5.95 0.34 8.47e-9 Breast cancer; CESC cis rs2299587 0.554 rs3913558 chr8:17747909 T/G cg08627089 chr8:17753878 FGL1 -0.41 -5.87 -0.34 1.33e-8 Economic and political preferences; CESC cis rs559928 0.606 rs57021319 chr11:63956102 G/A cg18225595 chr11:63971243 STIP1 0.69 6.2 0.36 2.17e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs10276381 1.000 rs10263857 chr7:28187284 C/G cg23620719 chr7:28220237 JAZF1 0.74 7.91 0.44 6.86e-14 Crohn's disease; CESC cis rs3768617 0.528 rs4652778 chr1:183097420 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 14.27 0.66 1.13e-34 Fuchs's corneal dystrophy; CESC cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg23978390 chr7:1156363 C7orf50 0.58 5.24 0.31 3.26e-7 Bronchopulmonary dysplasia; CESC cis rs10504229 0.593 rs1442127 chr8:57992136 T/C cg22535103 chr8:58192502 C8orf71 -0.66 -7.06 -0.4 1.45e-11 Developmental language disorder (linguistic errors); CESC cis rs10905065 0.861 rs10752069 chr10:5752403 A/G cg11519256 chr10:5708881 ASB13 0.48 6.43 0.37 5.95e-10 Menopause (age at onset); CESC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg14926445 chr8:58193284 C8orf71 -0.54 -5.14 -0.3 5.39e-7 Developmental language disorder (linguistic errors); CESC cis rs2281845 0.507 rs1536127 chr1:201086894 C/A cg06714761 chr1:201096289 NA 0.43 6.47 0.37 4.79e-10 Permanent tooth development; CESC cis rs8062405 1.000 rs62036617 chr16:28827498 T/C cg08761264 chr16:28874980 SH2B1 -0.46 -5.73 -0.33 2.73e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9790314 1.000 rs336548 chr3:161058412 T/C cg03342759 chr3:160939853 NMD3 -0.47 -6.07 -0.35 4.48e-9 Morning vs. evening chronotype; CESC cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg05347473 chr6:146136440 FBXO30 0.57 7.24 0.41 4.72e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs782590 0.934 rs62165184 chr2:55788253 G/C cg18811423 chr2:55921094 PNPT1 0.77 12.37 0.6 4.82e-28 Metabolic syndrome; CESC cis rs3820068 0.506 rs17448966 chr1:15990983 T/G cg13390004 chr1:15929781 NA 0.31 5.12 0.3 5.81e-7 Systolic blood pressure; CESC cis rs62005083 0.867 rs55785954 chr14:74633609 G/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.71 5.53 0.32 7.52e-8 Mean corpuscular volume; CESC cis rs6088580 0.634 rs4911418 chr20:32994257 G/A cg08999081 chr20:33150536 PIGU -0.65 -11.29 -0.57 2.22e-24 Glomerular filtration rate (creatinine); CESC cis rs3091242 0.933 rs10903130 chr1:25769221 A/T cg12412775 chr1:25698385 RHCE -0.28 -5.13 -0.3 5.65e-7 Erythrocyte sedimentation rate; CESC cis rs367615 0.659 rs13435970 chr5:108884660 C/T cg17395555 chr5:108820864 NA 0.55 8.19 0.45 1.14e-14 Colorectal cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14087051 chr9:34126687 DCAF12 0.58 6.67 0.38 1.46e-10 Gut microbiome composition (summer); CESC cis rs8027181 1.000 rs7166595 chr15:73094204 A/G cg25632853 chr15:73088954 NA 0.35 6.34 0.36 9.6e-10 Triglyceride levels; CESC cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg03467027 chr4:99064603 C4orf37 0.48 5.93 0.34 9.28e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3540 0.533 rs2601197 chr15:90940059 C/A cg10434728 chr15:90938212 IQGAP1 0.43 7.83 0.43 1.21e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11370512 chr12:113796654 PLBD2 -0.42 -6.75 -0.38 9.09e-11 Gambling; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg14060719 chr14:96797241 ATG2B 0.38 6.31 0.36 1.16e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7605827 0.893 rs1024871 chr2:15626162 C/T cg19274914 chr2:15703543 NA 0.36 6.42 0.37 6.36e-10 Educational attainment (years of education); CESC cis rs735860 0.726 rs209510 chr6:53202035 T/C cg10236188 chr6:53219634 NA 0.34 5.08 0.3 7.21e-7 Glaucoma; CESC cis rs7267979 1.000 rs422844 chr20:25445591 T/C cg08601574 chr20:25228251 PYGB 0.37 5.31 0.31 2.31e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg04756594 chr16:24857601 SLC5A11 -0.45 -5.48 -0.32 9.67e-8 Intelligence (multi-trait analysis); CESC cis rs5753618 0.504 rs9606847 chr22:31901789 G/C cg13145458 chr22:31556086 RNF185 -0.48 -5.69 -0.33 3.28e-8 Colorectal cancer; CESC cis rs1371867 0.846 rs1613453 chr8:101244215 G/T cg11906718 chr8:101322791 RNF19A -0.47 -5.97 -0.34 7.5e-9 Atrioventricular conduction; CESC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg24562669 chr7:97807699 LMTK2 0.52 7.41 0.41 1.66e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs11871801 0.517 rs35635959 chr17:40772288 T/C cg21433558 chr17:40837037 CNTNAP1 0.48 5.84 0.34 1.56e-8 Crohn's disease; CESC cis rs644148 0.770 rs2571113 chr19:44999814 A/G cg15540054 chr19:45004280 ZNF180 -0.71 -8.42 -0.46 2.38e-15 Personality dimensions; CESC trans rs208520 0.661 rs7766144 chr6:66827795 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.85 -0.62 1.09e-29 Exhaled nitric oxide output; CESC cis rs11155671 0.530 rs2342770 chr6:150216685 C/T cg11878867 chr6:150167359 LRP11 -0.35 -5.15 -0.3 5.02e-7 Testicular germ cell tumor; CESC cis rs6982240 0.514 rs10088801 chr8:142275801 T/C cg27411547 chr8:142287226 NA -0.53 -7.28 -0.41 3.69e-12 Tonsillectomy; CESC cis rs5769765 1.000 rs8184990 chr22:50273174 A/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.44 -0.32 1.23e-7 Schizophrenia; CESC cis rs7833986 0.501 rs2719255 chr8:57036658 A/G cg26371346 chr8:56986568 SNORD54;RPS20 0.56 5.04 0.3 8.57e-7 Height; CESC cis rs28374715 0.510 rs8034073 chr15:41545613 A/C cg18705301 chr15:41695430 NDUFAF1 -0.52 -7.21 -0.4 5.89e-12 Ulcerative colitis; CESC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.94 -11.28 -0.57 2.3e-24 Gut microbiome composition (summer); CESC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg17376030 chr22:41985996 PMM1 0.68 7.35 0.41 2.5e-12 Vitiligo; CESC cis rs8072100 0.790 rs11656856 chr17:45714671 C/T cg08085267 chr17:45401833 C17orf57 0.45 5.61 0.33 5.11e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs9929218 0.551 rs6499193 chr16:68727069 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.86 14.01 0.65 9.65e-34 Colorectal cancer; CESC cis rs1801251 1.000 rs283479 chr2:233648754 A/G cg25237894 chr2:233734115 C2orf82 0.46 7.81 0.43 1.33e-13 Coronary artery disease; CESC cis rs7044106 0.734 rs1981020 chr9:123388464 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 9.89 0.52 7.73e-20 Hip circumference adjusted for BMI; CESC cis rs4718428 0.705 rs4718424 chr7:66376095 G/A cg25985355 chr7:65971099 NA -0.34 -5.09 -0.3 6.81e-7 Corneal structure; CESC cis rs10129255 0.957 rs10142859 chr14:107190475 A/G cg23076370 chr14:107095027 NA -0.46 -5.79 -0.34 1.96e-8 Kawasaki disease; CESC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg04166393 chr7:2884313 GNA12 0.56 7.46 0.42 1.24e-12 Height; CESC cis rs9318086 0.712 rs9318100 chr13:24442482 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.44 -6.11 -0.35 3.61e-9 Myopia (pathological); CESC cis rs17407555 0.738 rs73212870 chr4:10111798 C/G cg11266682 chr4:10021025 SLC2A9 -0.49 -5.88 -0.34 1.24e-8 Schizophrenia (age at onset); CESC cis rs2180341 0.618 rs12199451 chr6:127597780 C/G cg24812749 chr6:127587940 RNF146 0.56 7.35 0.41 2.45e-12 Breast cancer; CESC cis rs1008375 0.898 rs4698623 chr4:17594702 T/C cg15017067 chr4:17643749 FAM184B 0.36 5.11 0.3 6.09e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg11494091 chr17:61959527 GH2 0.73 12.66 0.61 4.86e-29 Prudent dietary pattern; CESC cis rs17253792 0.822 rs77315200 chr14:56072643 C/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs6938 0.618 rs62029167 chr15:75228350 G/A cg17294928 chr15:75287854 SCAMP5 0.48 6.24 0.36 1.76e-9 Breast cancer; CESC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg22963979 chr7:1858916 MAD1L1 -0.38 -5.19 -0.3 4.18e-7 Bipolar disorder and schizophrenia; CESC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg22907277 chr7:1156413 C7orf50 0.41 5.97 0.34 7.76e-9 Longevity;Endometriosis; CESC cis rs7772486 0.790 rs6926657 chr6:146255794 G/A cg23711669 chr6:146136114 FBXO30 -0.92 -13.3 -0.63 2.94e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs1865721 0.804 rs1319789 chr18:73161157 C/A cg26385618 chr18:73139727 C18orf62 -0.45 -6.94 -0.39 3.02e-11 Intelligence; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10020083 chr5:176873646 PRR7 -0.52 -6.42 -0.37 6.19e-10 Asthma; CESC cis rs11030122 0.632 rs11030599 chr11:4031677 A/G cg18678763 chr11:4115507 RRM1 -0.42 -5.65 -0.33 4.19e-8 Mean platelet volume;Platelet distribution width; CESC cis rs921968 0.643 rs520095 chr2:219329485 C/T cg02176678 chr2:219576539 TTLL4 0.38 6.74 0.38 1.01e-10 Mean corpuscular hemoglobin concentration; CESC cis rs938554 0.513 rs11943372 chr4:9999346 T/A cg00071950 chr4:10020882 SLC2A9 0.62 8.36 0.46 3.61e-15 Blood metabolite levels; CESC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.68 0.38 1.41e-10 Intelligence (multi-trait analysis); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg05014452 chr15:79603196 TMED3 -0.4 -6.29 -0.36 1.27e-9 Vertical cup-disc ratio; CESC cis rs2243480 1.000 rs1701758 chr7:65470201 T/A cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs12701220 0.894 rs2141274 chr7:1034717 G/A cg26769984 chr7:1090371 C7orf50 0.52 6.19 0.36 2.3e-9 Bronchopulmonary dysplasia; CESC cis rs2901656 0.875 rs7516301 chr1:172372260 T/C cg03748243 chr1:172413542 C1orf105;PIGC 0.41 5.99 0.35 6.87e-9 Red cell distribution width;Platelet distribution width; CESC cis rs7193541 0.684 rs7201320 chr16:74694058 T/G cg05580060 chr16:74700937 RFWD3 -0.5 -6.49 -0.37 4.27e-10 Multiple myeloma; CESC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10489202 0.632 rs202265 chr1:167990231 G/C cg24449463 chr1:168025552 DCAF6 -0.41 -5.24 -0.31 3.33e-7 Schizophrenia; CESC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg10074409 chr1:209979377 IRF6 0.4 5.32 0.31 2.16e-7 Cleft lip with or without cleft palate; CESC cis rs916888 0.821 rs199513 chr17:44856932 A/G cg15921436 chr17:44337874 NA -0.65 -7.14 -0.4 9.23e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9640161 0.659 rs7806429 chr7:150013393 A/G cg10018233 chr7:150070692 REPIN1 0.45 7.16 0.4 8.07e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg05564831 chr3:52568323 NT5DC2 0.47 7.46 0.42 1.24e-12 Electroencephalogram traits; CESC cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg21226059 chr5:178986404 RUFY1 0.45 6.32 0.36 1.09e-9 Lung cancer; CESC cis rs3892630 0.878 rs11878394 chr19:33205844 G/C cg22980127 chr19:33182716 NUDT19 1.02 10.92 0.56 3.55e-23 Red blood cell traits; CESC trans rs5763662 1.000 rs5763769 chr22:30495745 G/A cg23513814 chr17:72857430 GRIN2C -0.53 -6.04 -0.35 5.1e-9 LDL cholesterol levels;LDL cholesterol; CESC cis rs854765 0.547 rs7209003 chr17:17907393 T/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.23 0.41 5.11e-12 Total body bone mineral density; CESC cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg18876405 chr7:65276391 NA 0.49 5.33 0.31 2.1e-7 Aortic root size; CESC trans rs2235573 0.625 rs139901 chr22:38406147 T/C cg19894588 chr14:64061835 NA 0.49 6.27 0.36 1.43e-9 Glioblastoma;Glioma; CESC cis rs473651 0.935 rs474478 chr2:239335473 C/T cg21699342 chr2:239360505 ASB1 0.53 8.62 0.47 6.17e-16 Multiple system atrophy; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00767560 chr19:19887256 LOC284440 0.47 6.41 0.37 6.74e-10 Systemic lupus erythematosus; CESC cis rs8067545 0.578 rs9901336 chr17:20064190 G/A cg13482628 chr17:19912719 NA 0.42 5.5 0.32 8.74e-8 Schizophrenia; CESC cis rs7208859 0.725 rs9915802 chr17:29173058 T/C cg19761014 chr17:28927070 LRRC37B2 0.57 5.71 0.33 2.96e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4722166 0.532 rs1404008 chr7:22756000 A/T cg05472934 chr7:22766657 IL6 0.5 6.56 0.37 2.73e-10 Lung cancer; CESC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg24250549 chr1:154909240 PMVK 0.74 11.08 0.56 1.06e-23 Prostate cancer; CESC cis rs7937682 0.855 rs490897 chr11:111487914 A/G cg22437258 chr11:111473054 SIK2 0.71 9.48 0.5 1.47e-18 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23586394 chr17:8286572 RPL26 0.55 6.51 0.37 3.71e-10 Gut microbiome composition (summer); CESC trans rs875971 1.000 rs55962648 chr7:65625751 C/G cg26939375 chr7:64535504 NA -0.46 -6.09 -0.35 4e-9 Aortic root size; CESC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg17158414 chr2:27665306 KRTCAP3 -0.34 -6.34 -0.36 9.82e-10 Total body bone mineral density; CESC cis rs9611565 0.649 rs202657 chr22:41844786 G/T cg03806693 chr22:41940476 POLR3H 1.19 14.51 0.67 1.64e-35 Vitiligo; CESC trans rs801193 1.000 rs7789184 chr7:66210195 A/T cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC cis rs1728785 1.000 rs1170429 chr16:68604126 A/G cg02972257 chr16:68554789 NA -0.59 -6.71 -0.38 1.2e-10 Ulcerative colitis; CESC cis rs2573652 1.000 rs2581341 chr15:100514494 T/C cg09918751 chr15:100517450 ADAMTS17 -0.41 -7.8 -0.43 1.47e-13 Height; CESC cis rs77106637 1.000 rs11602858 chr11:72615069 C/G cg03713592 chr11:72463424 ARAP1 1.11 10.14 0.53 1.25e-20 Type 2 diabetes; CESC cis rs10504229 0.679 rs72649107 chr8:58030453 C/A cg22535103 chr8:58192502 C8orf71 -0.57 -6.56 -0.37 2.78e-10 Developmental language disorder (linguistic errors); CESC trans rs8073060 0.586 rs6505486 chr17:33996776 G/A cg19694781 chr19:47549865 TMEM160 -0.75 -7.09 -0.4 1.2e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs3091242 0.933 rs932372 chr1:25755014 G/A cg27572855 chr1:25598939 RHD 0.46 7.61 0.42 4.83e-13 Erythrocyte sedimentation rate; CESC cis rs9399135 0.816 rs4134030 chr6:135354094 G/T cg24558204 chr6:135376177 HBS1L 0.51 7.09 0.4 1.25e-11 Red blood cell count; CESC cis rs1797885 1.000 rs1797885 chr3:12517103 G/A cg26432171 chr3:12704882 RAF1 -0.5 -6.42 -0.37 6.13e-10 Immature fraction of reticulocytes; CESC cis rs11864453 0.713 rs12708927 chr16:72126165 C/T cg01557791 chr16:72042693 DHODH -0.46 -5.92 -0.34 9.98e-9 Fibrinogen levels; CESC cis rs9814567 0.896 rs2177602 chr3:134245866 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.15 -0.35 2.87e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs10129255 0.518 rs10150460 chr14:107133196 C/G cg07958169 chr14:107095056 NA 0.56 9.29 0.5 5.64e-18 Kawasaki disease; CESC cis rs7772486 0.754 rs6910790 chr6:146255330 G/A cg05347473 chr6:146136440 FBXO30 -0.55 -7.0 -0.39 2.12e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9303401 0.614 rs2240719 chr17:56582477 G/C cg25039879 chr17:56429692 SUPT4H1 0.51 5.11 0.3 6.24e-7 Cognitive test performance; CESC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg04944784 chr2:26401820 FAM59B -0.65 -7.42 -0.41 1.56e-12 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg12463550 chr7:65579703 CRCP -0.5 -6.32 -0.36 1.08e-9 Aortic root size; CESC trans rs7726839 0.540 rs61580655 chr5:597564 A/G cg25482853 chr8:67687455 SGK3 1.04 10.08 0.53 1.87e-20 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10546579 chr7:44646217 OGDH 0.57 6.56 0.37 2.88e-10 Gut microbiome composition (summer); CESC cis rs208520 0.507 rs7755710 chr6:66783355 G/A cg07460842 chr6:66804631 NA -1.09 -25.19 -0.84 2.82e-72 Exhaled nitric oxide output; CESC cis rs6688613 0.694 rs1476347 chr1:166815587 G/T cg07049167 chr1:166818506 POGK 0.55 6.76 0.38 8.62e-11 Refractive astigmatism; CESC cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg14584255 chr6:163149320 PACRG;PARK2 -0.43 -5.36 -0.31 1.81e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2425143 1.000 rs6060642 chr20:34449840 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.78 -7.03 -0.4 1.78e-11 Blood protein levels; CESC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg17971929 chr21:40555470 PSMG1 1.07 16.32 0.71 6.47e-42 Cognitive function; CESC cis rs17407555 0.821 rs80278615 chr4:10143666 G/A cg11266682 chr4:10021025 SLC2A9 -0.51 -5.73 -0.33 2.79e-8 Schizophrenia (age at onset); CESC cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -9.52 -0.5 1.15e-18 Extrinsic epigenetic age acceleration; CESC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg12963246 chr6:28129442 ZNF389 0.42 5.78 0.33 2.1e-8 Parkinson's disease; CESC cis rs2625529 0.529 rs1552133 chr15:72232897 T/A cg16672083 chr15:72433130 SENP8 0.43 6.2 0.36 2.1e-9 Red blood cell count; CESC cis rs3096299 0.748 rs2965822 chr16:89444677 A/T cg02187348 chr16:89574699 SPG7 0.52 6.82 0.39 6.32e-11 Multiple myeloma (IgH translocation); CESC cis rs17253792 0.822 rs13379342 chr14:56050452 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.8 0.34 1.89e-8 Putamen volume; CESC cis rs4889855 0.585 rs72855201 chr17:78530597 A/G cg16591659 chr17:78472290 NA 0.38 6.27 0.36 1.47e-9 Fractional excretion of uric acid; CESC cis rs11122272 0.735 rs1416916 chr1:231533027 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs4891159 0.790 rs7234653 chr18:74111988 C/T cg24786174 chr18:74118243 ZNF516 -0.75 -11.88 -0.59 2.16e-26 Longevity; CESC cis rs2197308 0.585 rs10878014 chr12:38114496 A/G cg26384229 chr12:38710491 ALG10B 0.42 5.67 0.33 3.8e-8 Morning vs. evening chronotype; CESC cis rs7116495 1.000 rs2298456 chr11:71730715 A/T cg10381502 chr11:71823885 C11orf51 0.62 5.35 0.31 1.94e-7 Severe influenza A (H1N1) infection; CESC cis rs7086627 0.515 rs11202960 chr10:82209807 G/A cg03267442 chr10:82210566 NA -0.34 -5.6 -0.33 5.45e-8 Post bronchodilator FEV1; CESC cis rs2236918 0.932 rs1635517 chr1:242012033 A/G cg17736920 chr1:242011382 EXO1 -0.74 -9.93 -0.52 5.65e-20 Menopause (age at onset); CESC cis rs472402 0.560 rs10065299 chr5:6654489 T/C cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.55 -7.06 -0.4 1.43e-11 Response to amphetamines; CESC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg13206674 chr6:150067644 NUP43 0.43 6.05 0.35 4.94e-9 Lung cancer; CESC cis rs116095464 0.558 rs28418643 chr5:240859 A/G cg20965017 chr5:231967 SDHA -0.47 -5.3 -0.31 2.49e-7 Breast cancer; CESC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg05564831 chr3:52568323 NT5DC2 0.46 7.26 0.41 4.25e-12 Bipolar disorder; CESC cis rs116095464 0.558 rs73029475 chr5:206969 T/C cg22857025 chr5:266934 NA -1.28 -14.21 -0.66 1.88e-34 Breast cancer; CESC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg22105103 chr4:187893119 NA 0.47 7.09 0.4 1.22e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1006703 0.544 rs8067516 chr17:3838248 T/C cg06463185 chr17:3833770 ATP2A3 -0.63 -6.08 -0.35 4.1e-9 Glucose homeostasis traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20969242 chr1:155827044 GON4L -0.53 -6.51 -0.37 3.78e-10 Gut microbiome composition (summer); CESC trans rs12339966 0.643 rs2586342 chr9:11677445 A/G cg03904639 chr13:37677730 CSNK1A1L 0.39 6.06 0.35 4.67e-9 Systolic blood pressure; CESC cis rs17376456 0.877 rs13153245 chr5:93374891 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.18 0.3 4.41e-7 Diabetic retinopathy; CESC trans rs11250098 0.567 rs4326350 chr8:10763655 C/G cg15556689 chr8:8085844 FLJ10661 0.56 6.81 0.39 6.67e-11 Morning vs. evening chronotype; CESC cis rs10992471 0.756 rs3758229 chr9:95078852 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.43 -5.41 -0.32 1.39e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.13 -0.3 5.47e-7 Glomerular filtration rate (creatinine); CESC cis rs6912958 0.781 rs9444512 chr6:88223397 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.37 -6.01 -0.35 6.1e-9 Monocyte percentage of white cells; CESC cis rs8038465 0.622 rs60696711 chr15:73873005 C/A cg15420318 chr15:73925796 NPTN 0.49 6.87 0.39 4.6e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4919694 1.000 rs7083328 chr10:104769268 G/A cg04362960 chr10:104952993 NT5C2 0.75 6.44 0.37 5.54e-10 Arsenic metabolism; CESC cis rs1451375 0.617 rs10271341 chr7:50591583 A/C cg14593290 chr7:50529359 DDC 0.49 5.92 0.34 9.95e-9 Malaria; CESC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg26839252 chr6:160211577 TCP1;MRPL18 0.45 5.35 0.31 1.92e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs763121 0.776 rs4820346 chr22:39125074 C/G cg21395723 chr22:39101663 GTPBP1 -0.45 -5.69 -0.33 3.36e-8 Menopause (age at onset); CESC cis rs12618769 0.570 rs116051325 chr2:99056836 G/A cg10123293 chr2:99228465 UNC50 0.39 5.18 0.3 4.49e-7 Bipolar disorder; CESC cis rs16867321 0.627 rs1950028 chr2:181587222 A/G cg23363182 chr2:181467187 NA -0.43 -5.67 -0.33 3.7e-8 Obesity; CESC trans rs2797160 0.651 rs6939969 chr6:126034563 C/T cg05039488 chr6:79577232 IRAK1BP1 0.47 6.36 0.36 8.95e-10 Endometrial cancer; CESC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg04772025 chr11:68637568 NA 0.53 6.38 0.37 7.7e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg01448562 chr3:133502909 NA 0.42 5.66 0.33 3.93e-8 Iron status biomarkers; CESC cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg04317338 chr11:64019027 PLCB3 0.49 5.78 0.33 2.06e-8 Platelet count; CESC cis rs644799 1.000 rs693364 chr11:95621926 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.83 11.71 0.58 8.53e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7178572 1.000 rs965480 chr15:77781926 A/G cg22256960 chr15:77711686 NA -0.6 -8.09 -0.44 2.19e-14 Type 2 diabetes; CESC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg22920501 chr2:26401640 FAM59B -0.85 -10.05 -0.53 2.5e-20 Gut microbiome composition (summer); CESC cis rs8077577 0.895 rs13284 chr17:18112130 C/T cg16794390 chr17:18148240 FLII 0.41 5.64 0.33 4.37e-8 Obesity-related traits; CESC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg18758796 chr5:131593413 PDLIM4 0.45 6.31 0.36 1.19e-9 Breast cancer; CESC trans rs3087243 0.755 rs6714925 chr2:204694235 T/A cg01841312 chr10:38069945 NA -0.4 -6.67 -0.38 1.52e-10 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs7605827 0.930 rs6737962 chr2:15526998 T/G cg19274914 chr2:15703543 NA 0.35 6.11 0.35 3.61e-9 Educational attainment (years of education); CESC cis rs2274273 1.000 rs72718804 chr14:55630610 G/A cg04306507 chr14:55594613 LGALS3 0.29 5.32 0.31 2.21e-7 Protein biomarker; CESC cis rs2236521 0.659 rs72487383 chr20:60889313 A/C cg09594475 chr20:60884601 LAMA5 0.49 6.63 0.38 1.91e-10 Pelvic organ prolapse; CESC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 11.42 0.57 7.76e-25 Platelet count; CESC cis rs1879734 0.689 rs6673378 chr1:54160812 G/T cg23596471 chr1:54105337 GLIS1 0.35 5.56 0.32 6.52e-8 Mitral valve prolapse; CESC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.82 0.62 1.32e-29 Personality dimensions; CESC cis rs9914988 0.887 rs34644886 chr17:27168327 T/C cg20469991 chr17:27169893 C17orf63 -0.46 -5.11 -0.3 6.27e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs4535700 0.501 rs28678267 chr7:56009490 A/G cg09872392 chr7:56161020 PHKG1 0.41 5.9 0.34 1.08e-8 Macular telangiectasia type 2; CESC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg07507251 chr3:52567010 NT5DC2 0.43 7.13 0.4 9.6e-12 Bipolar disorder; CESC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2337406 0.714 rs2337463 chr14:107224299 A/G cg23076370 chr14:107095027 NA -0.48 -5.26 -0.31 2.93e-7 Alzheimer's disease (late onset); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg12512039 chr7:65958832 NA 0.57 6.4 0.37 7.19e-10 Psoriatic arthritis; CESC trans rs1814175 0.817 rs4405313 chr11:50013636 G/A cg03929089 chr4:120376271 NA -0.94 -16.01 -0.7 7.75e-41 Height; CESC cis rs4835473 0.932 rs1839449 chr4:144651375 A/G cg25736465 chr4:144833511 NA 0.36 5.42 0.32 1.31e-7 Immature fraction of reticulocytes; CESC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.59e-9 Total body bone mineral density; CESC cis rs2197308 0.765 rs12824529 chr12:37931656 T/C cg13010199 chr12:38710504 ALG10B 0.53 6.81 0.39 6.71e-11 Morning vs. evening chronotype; CESC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg11644478 chr21:40555479 PSMG1 1.04 16.65 0.71 4.41e-43 Cognitive function; CESC cis rs6546550 0.900 rs2054047 chr2:70117421 A/C cg02498382 chr2:70120550 SNRNP27 -0.41 -7.0 -0.39 2.11e-11 Prevalent atrial fibrillation; CESC cis rs10504073 0.584 rs56074306 chr8:49940282 C/T cg00325661 chr8:49890786 NA 0.58 8.62 0.47 6.09e-16 Blood metabolite ratios; CESC trans rs7902708 0.920 rs11002989 chr10:54425167 C/T cg26219051 chr22:43739629 SCUBE1 -0.48 -6.19 -0.36 2.25e-9 Bone properties (heel); CESC cis rs2708240 0.666 rs2710118 chr7:147603362 A/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.58 -0.32 6.03e-8 QT interval (drug interaction); CESC cis rs11640734 0.609 rs11647746 chr16:89806343 C/A cg14709524 chr16:89940631 TCF25 0.59 5.03 0.3 9.18e-7 Interleukin-17 levels; CESC cis rs7296418 0.738 rs10846489 chr12:123743927 A/G cg05973401 chr12:123451056 ABCB9 -0.47 -6.05 -0.35 5.01e-9 Platelet count; CESC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg05368731 chr17:41323189 NBR1 0.77 11.01 0.56 1.79e-23 Menopause (age at onset); CESC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.16 0.3 4.96e-7 Menopause (age at onset); CESC cis rs7760535 0.597 rs9320368 chr6:111904737 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.44 -6.68 -0.38 1.36e-10 Metabolic traits; CESC cis rs77861329 0.748 rs747343 chr3:52109407 T/C cg08692210 chr3:52188851 WDR51A 0.46 5.43 0.32 1.25e-7 Macrophage inflammatory protein 1b levels; CESC cis rs12822507 0.899 rs4763859 chr12:12787005 G/A cg11838227 chr12:12764436 CREBL2 -0.41 -5.33 -0.31 2.1e-7 Systemic lupus erythematosus; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03409120 chr17:58754402 BCAS3 0.45 6.74 0.38 9.87e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4450798 0.793 rs4640541 chr3:13758997 C/G cg05589046 chr3:13742034 LOC285375 -0.38 -5.8 -0.34 1.88e-8 Bipolar disorder with mood-incongruent psychosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14304014 chr19:1625356 TCF3 0.43 6.27 0.36 1.44e-9 Fibrinogen levels; CESC cis rs6912958 0.702 rs2300909 chr6:88212100 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.62 -0.38 1.95e-10 Monocyte percentage of white cells; CESC cis rs362272 0.505 rs13104157 chr4:3366950 T/C cg14583973 chr4:3374767 RGS12 0.31 5.48 0.32 9.88e-8 Serum sulfate level; CESC cis rs4668356 0.892 rs1863679 chr2:172017906 C/T cg13882835 chr2:172017928 TLK1 0.52 5.13 0.3 5.61e-7 Cognitive performance; CESC cis rs9640161 0.789 rs4554381 chr7:150025567 G/A cg21361702 chr7:150065534 REPIN1 0.47 5.58 0.32 5.88e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs17401966 1.000 rs3753037 chr1:10355834 C/T cg15208524 chr1:10270712 KIF1B 0.48 6.13 0.35 3.2e-9 Hepatocellular carcinoma; CESC cis rs6032067 0.777 rs2868236 chr20:43794070 G/A cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs896854 0.517 rs1011795 chr8:95951073 G/A cg16049864 chr8:95962084 TP53INP1 -0.53 -7.59 -0.42 5.61e-13 Type 2 diabetes; CESC cis rs2204008 0.715 rs11514282 chr12:38169056 G/T cg26384229 chr12:38710491 ALG10B 0.75 10.86 0.55 5.81e-23 Bladder cancer; CESC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg16606324 chr3:10149918 C3orf24 0.43 5.36 0.31 1.81e-7 Alzheimer's disease; CESC cis rs10206020 0.921 rs4072986 chr2:1547734 C/G cg01028140 chr2:1542097 TPO -0.47 -5.93 -0.34 9.62e-9 IgG glycosylation; CESC cis rs1348850 0.750 rs12997716 chr2:178494629 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 6.59 0.38 2.42e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs5769765 0.954 rs5770707 chr22:50244533 G/A cg26441486 chr22:50317300 CRELD2 -0.4 -5.52 -0.32 8.04e-8 Schizophrenia; CESC cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg06022373 chr22:39101656 GTPBP1 -0.88 -13.54 -0.64 4.17e-32 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00067814 chr7:134896357 WDR91 0.54 6.05 0.35 5.04e-9 Gut microbiome composition (summer); CESC cis rs611744 0.647 rs633901 chr8:109242981 G/T cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.65e-8 Dupuytren's disease; CESC cis rs2282802 0.685 rs13177186 chr5:139640476 A/G cg26211634 chr5:139558579 C5orf32 0.53 7.66 0.43 3.55e-13 Intelligence (multi-trait analysis); CESC cis rs2760061 0.598 rs2796056 chr1:228122901 G/A cg02753203 chr1:228287806 NA -0.51 -7.36 -0.41 2.3e-12 Diastolic blood pressure; CESC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg11366901 chr6:160182831 ACAT2 0.83 10.38 0.54 2.06e-21 Age-related macular degeneration (geographic atrophy); CESC cis rs7546094 0.935 rs6700673 chr1:113157054 C/T cg22162597 chr1:113214053 CAPZA1 0.4 6.13 0.35 3.09e-9 Platelet distribution width; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27559595 chr15:79237381 CTSH -0.44 -6.1 -0.35 3.73e-9 Fibrinogen levels; CESC cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg05340658 chr4:99064831 C4orf37 0.59 7.45 0.42 1.32e-12 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.963 rs34907901 chr1:46405214 T/G cg05343316 chr1:45956843 TESK2 0.43 5.2 0.3 3.9e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg18110333 chr6:292329 DUSP22 -0.74 -9.98 -0.52 4.17e-20 Menopause (age at onset); CESC cis rs36051895 0.632 rs1581927 chr9:5177462 C/T cg02405213 chr9:5042618 JAK2 -0.51 -6.62 -0.38 2.03e-10 Pediatric autoimmune diseases; CESC cis rs4594175 0.886 rs11157802 chr14:51622984 C/T cg23942311 chr14:51606299 NA 0.39 5.95 0.34 8.67e-9 Cancer; CESC cis rs28647808 0.881 rs71483208 chr9:136258824 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC trans rs473518 0.891 rs554856 chr18:20103788 A/C cg20346503 chr2:128994402 NA 0.47 6.32 0.36 1.11e-9 Migraine - clinic-based; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24424381 chr15:90233857 WDR93;PEX11A -0.53 -6.57 -0.37 2.72e-10 Asthma; CESC cis rs847577 0.748 rs940430 chr7:97716540 A/G cg24562669 chr7:97807699 LMTK2 0.63 10.15 0.53 1.13e-20 Breast cancer; CESC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg00166722 chr3:10149974 C3orf24 0.47 5.91 0.34 1.05e-8 Alzheimer's disease; CESC cis rs2070488 0.775 rs2268762 chr3:38516075 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 13.35 0.63 2.01e-31 Electrocardiographic conduction measures; CESC cis rs1499972 0.529 rs58533135 chr3:117655311 T/C cg07612923 chr3:117604196 NA 0.69 6.3 0.36 1.22e-9 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05994294 chr4:1374658 KIAA1530 -0.58 -6.9 -0.39 3.93e-11 Gut microbiome composition (summer); CESC cis rs858239 0.632 rs7811903 chr7:23119056 A/G cg23682824 chr7:23144976 KLHL7 0.55 7.61 0.42 4.7e-13 Cerebrospinal fluid biomarker levels; CESC cis rs6429082 0.783 rs291385 chr1:235646613 T/C cg26050004 chr1:235667680 B3GALNT2 0.62 7.88 0.44 8.78e-14 Adiposity; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09571097 chr17:899782 TIMM22 -0.45 -6.29 -0.36 1.31e-9 Asthma; CESC cis rs11166927 1.000 rs13260415 chr8:140805137 A/C cg16909799 chr8:140841666 TRAPPC9 0.61 8.99 0.48 4.89e-17 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs477692 1.000 rs479478 chr10:131428959 G/A cg05714579 chr10:131428358 MGMT 0.52 7.09 0.4 1.21e-11 Response to temozolomide; CESC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg01341218 chr17:43662625 NA 0.92 10.84 0.55 6.44e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7243790 0.805 rs7243441 chr18:51917733 C/T cg04730925 chr18:51795821 POLI -0.43 -5.68 -0.33 3.47e-8 Diastolic blood pressure; CESC cis rs6582630 0.502 rs11610978 chr12:38356957 C/G cg13010199 chr12:38710504 ALG10B 0.44 5.58 0.32 5.9e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs2019216 0.500 rs6565385 chr17:21897646 C/A cg22648282 chr17:21454238 C17orf51 -0.42 -5.55 -0.32 6.94e-8 Pelvic organ prolapse; CESC cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.41 -5.3 -0.31 2.5e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1881797 1.000 rs1881797 chr1:247689532 A/G cg05639522 chr1:247681581 NA 0.44 6.69 0.38 1.33e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg26939375 chr7:64535504 NA 0.78 10.85 0.55 6.36e-23 Aortic root size; CESC cis rs4474465 1.000 rs7950865 chr11:78157401 A/G cg27205649 chr11:78285834 NARS2 -0.41 -5.13 -0.3 5.53e-7 Alzheimer's disease (survival time); CESC cis rs72945132 0.714 rs57320340 chr11:70160010 G/C cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs757110 0.648 rs12146443 chr11:17384498 T/C cg15432903 chr11:17409602 KCNJ11 0.6 8.51 0.46 1.3e-15 Type 2 diabetes; CESC cis rs796364 1.000 rs281783 chr2:200751582 G/A cg23649088 chr2:200775458 C2orf69 0.56 5.25 0.31 3.09e-7 Schizophrenia; CESC trans rs1814175 0.645 rs28478790 chr11:50054322 C/A cg03929089 chr4:120376271 NA -0.91 -14.82 -0.67 1.29e-36 Height; CESC cis rs9291683 0.546 rs13146686 chr4:10034933 A/G cg02734326 chr4:10020555 SLC2A9 0.43 5.97 0.34 7.52e-9 Bone mineral density; CESC cis rs921968 0.510 rs591573 chr2:219478193 C/T cg02176678 chr2:219576539 TTLL4 0.44 7.54 0.42 7.44e-13 Mean corpuscular hemoglobin concentration; CESC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg10596483 chr8:143751796 JRK 0.43 5.19 0.3 4.28e-7 Urinary tract infection frequency; CESC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.3 0.63 2.84e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3793683 0.545 rs12784407 chr10:134589631 A/G cg18305652 chr10:134549665 INPP5A 0.48 6.79 0.39 7.14e-11 Migraine; CESC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7937682 0.632 rs3944619 chr11:111774743 A/G cg09085632 chr11:111637200 PPP2R1B 0.88 11.26 0.57 2.77e-24 Primary sclerosing cholangitis; CESC cis rs7762018 0.769 rs4716339 chr6:170063210 C/T cg05834625 chr6:170176447 C6orf70 0.51 5.22 0.31 3.6e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg08704250 chr15:31115839 NA -0.63 -8.15 -0.45 1.44e-14 Huntington's disease progression; CESC cis rs7607369 0.559 rs4674339 chr2:219659787 C/G cg02176678 chr2:219576539 TTLL4 -0.4 -7.23 -0.41 5.21e-12 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs561341 1.000 rs484175 chr17:30309041 G/A cg19193384 chr17:30244184 NA -0.67 -6.36 -0.36 8.74e-10 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23539780 chr8:10696689 PINX1 -0.58 -6.61 -0.38 2.08e-10 Gut microbiome composition (summer); CESC cis rs17376456 0.825 rs10054903 chr5:93281491 C/A cg21475434 chr5:93447410 FAM172A 0.75 6.27 0.36 1.5e-9 Diabetic retinopathy; CESC cis rs4704187 0.595 rs6859176 chr5:74379425 T/C cg03227963 chr5:74354835 NA 0.32 5.95 0.34 8.68e-9 Response to amphetamines; CESC cis rs2857078 0.720 rs9906669 chr17:42305706 A/G cg19774624 chr17:42201019 HDAC5 -0.55 -7.41 -0.41 1.75e-12 Red cell distribution width;Reticulocyte count; CESC trans rs9354308 0.933 rs55672811 chr6:66571730 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 7.93 0.44 6.11e-14 Metabolite levels; CESC cis rs9457247 1.000 rs385113 chr6:167403971 A/G cg07741184 chr6:167504864 NA 0.28 5.1 0.3 6.54e-7 Crohn's disease; CESC cis rs7267979 1.000 rs2424700 chr20:25266513 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.3e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs9840812 0.567 rs2655008 chr3:136123775 A/T cg15507776 chr3:136538369 TMEM22 0.42 5.11 0.3 6.2e-7 Fibrinogen levels; CESC trans rs11098499 0.863 rs2306456 chr4:120472422 C/G cg25214090 chr10:38739885 LOC399744 0.66 8.96 0.48 5.92e-17 Corneal astigmatism; CESC trans rs11165623 0.765 rs11807955 chr1:96891623 C/T cg10631902 chr5:14652156 NA -0.57 -8.51 -0.46 1.31e-15 Hip circumference;Waist circumference; CESC cis rs7914558 0.966 rs11191518 chr10:104782853 C/G cg08650961 chr10:104748594 CNNM2 0.33 5.43 0.32 1.29e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs447 0.848 rs9969195 chr7:83753142 T/C cg22846510 chr7:83753280 SEMA3A -0.45 -5.61 -0.33 5e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07058132 chr16:1755945 MAPK8IP3 -0.46 -6.21 -0.36 1.98e-9 Ulcerative colitis; CESC cis rs728616 0.681 rs55899456 chr10:82050646 G/A cg05935833 chr10:81318306 SFTPA2 -0.44 -5.53 -0.32 7.71e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg11663144 chr21:46675770 NA -0.63 -9.96 -0.52 4.67e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8114671 0.562 rs6088642 chr20:33483186 G/T cg24642439 chr20:33292090 TP53INP2 0.44 5.32 0.31 2.18e-7 Height; CESC cis rs7727544 0.631 rs13357280 chr5:131600187 A/G cg14196790 chr5:131705035 SLC22A5 0.38 5.67 0.33 3.81e-8 Blood metabolite levels; CESC cis rs28680850 1.000 rs28680850 chr8:1373720 G/A cg02490460 chr8:1365502 NA -0.42 -5.19 -0.3 4.11e-7 Triglycerides; CESC cis rs2486288 0.586 rs12909883 chr15:45572054 G/C cg09092052 chr15:45571596 NA 0.44 5.23 0.31 3.44e-7 Glomerular filtration rate; CESC trans rs3741578 0.702 rs1813812 chr12:57333395 A/G cg27208169 chr17:17603584 RAI1 0.44 6.07 0.35 4.31e-9 Asthma; CESC cis rs654950 0.934 rs662999 chr1:42001160 A/C cg06885757 chr1:42089581 HIVEP3 0.65 9.93 0.52 5.8e-20 Airway imaging phenotypes; CESC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg07677032 chr17:61819896 STRADA 0.5 6.66 0.38 1.55e-10 Prudent dietary pattern; CESC cis rs11864453 0.826 rs12448315 chr16:72147242 G/T cg01557791 chr16:72042693 DHODH -0.52 -6.82 -0.39 6.06e-11 Fibrinogen levels; CESC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg10792982 chr14:105748885 BRF1 0.4 5.04 0.3 8.82e-7 Mean platelet volume;Platelet distribution width; CESC cis rs4132509 1.000 rs9782958 chr1:243892972 C/G cg21452805 chr1:244014465 NA 0.45 5.68 0.33 3.5e-8 RR interval (heart rate); CESC cis rs35110281 0.782 rs6518309 chr21:45047992 C/A cg04455712 chr21:45112962 RRP1B 0.43 5.95 0.34 8.28e-9 Mean corpuscular volume; CESC cis rs3008870 1.000 rs2985822 chr1:67404910 T/G cg02640540 chr1:67518911 SLC35D1 0.52 5.66 0.33 3.9e-8 Lymphocyte percentage of white cells; CESC cis rs11677416 1.000 rs1516790 chr2:113531291 G/A cg27083787 chr2:113543245 IL1A 0.41 5.17 0.3 4.53e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg25072359 chr17:41440525 NA 0.47 6.26 0.36 1.51e-9 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11582617 chr6:158589302 SERAC1;GTF2H5 -0.43 -6.09 -0.35 3.92e-9 Fibrinogen levels; CESC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg06420487 chr17:61919686 SMARCD2 0.47 5.55 0.32 6.89e-8 Height; CESC cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg12365402 chr11:9010492 NRIP3 -0.33 -5.25 -0.31 3.14e-7 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06086071 chr1:151847151 THEM4 -0.57 -6.2 -0.36 2.17e-9 Gut microbiome composition (summer); CESC cis rs9926296 0.632 rs4785717 chr16:89801133 A/G cg27121462 chr16:89883253 FANCA 0.63 8.05 0.44 2.77e-14 Vitiligo; CESC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -7.76 -0.43 1.81e-13 Tonsillectomy; CESC cis rs7914558 0.933 rs12763665 chr10:104653717 G/A cg04362960 chr10:104952993 NT5C2 0.46 5.99 0.35 6.65e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs155076 1.000 rs484365 chr13:21845944 G/T cg11317459 chr13:21872234 NA -1.01 -11.12 -0.56 7.88e-24 White matter hyperintensity burden; CESC cis rs9888739 1.000 rs11865746 chr16:31326587 T/G cg15817542 chr16:31343056 ITGAM -0.46 -5.46 -0.32 1.11e-7 Systemic lupus erythematosus; CESC trans rs57221529 0.713 rs56328416 chr5:591138 G/A cg25482853 chr8:67687455 SGK3 1.02 9.96 0.52 4.61e-20 Lung disease severity in cystic fibrosis; CESC cis rs12971120 0.891 rs12608037 chr18:72169395 A/G cg25817165 chr18:72167213 CNDP2 -0.61 -7.15 -0.4 8.4e-12 Refractive error; CESC cis rs77106637 0.932 rs2886599 chr11:72721271 C/A cg04827223 chr11:72435913 ARAP1 -0.53 -5.44 -0.32 1.2e-7 Type 2 diabetes; CESC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs3126085 1.000 rs4845756 chr1:152254919 T/A cg03465714 chr1:152285911 FLG -0.46 -5.75 -0.33 2.42e-8 Atopic dermatitis; CESC cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg05340658 chr4:99064831 C4orf37 0.76 11.26 0.57 2.68e-24 Colonoscopy-negative controls vs population controls; CESC trans rs1888221 0.580 rs7030164 chr9:117815613 C/T cg11017500 chr13:111290755 CARKD -0.46 -6.06 -0.35 4.61e-9 Glucose homeostasis traits; CESC cis rs9715521 0.677 rs62301200 chr4:59855179 G/A cg11281224 chr4:60001000 NA -0.51 -7.15 -0.4 8.65e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15154797 chr10:91174526 IFIT5 -0.45 -6.0 -0.35 6.28e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09256781 chr7:23145220 KLHL7 0.6 6.58 0.37 2.44e-10 Gut microbiome composition (summer); CESC cis rs12497850 1.000 rs10865952 chr3:48744484 A/G cg07636037 chr3:49044803 WDR6 0.95 16.31 0.71 6.93e-42 Parkinson's disease; CESC cis rs12136530 0.509 rs77930907 chr1:19724752 G/C cg01832549 chr1:19774989 CAPZB -0.46 -6.29 -0.36 1.32e-9 Lead levels in blood; CESC cis rs7772486 0.846 rs1331636 chr6:146338826 T/C cg23711669 chr6:146136114 FBXO30 0.86 12.53 0.61 1.39e-28 Lobe attachment (rater-scored or self-reported); CESC trans rs208520 0.690 rs12202401 chr6:66760544 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 12.07 0.6 5.01e-27 Exhaled nitric oxide output; CESC cis rs1152591 0.624 rs1266927 chr14:64651663 C/A cg21174375 chr14:64681225 SYNE2 0.49 6.96 0.39 2.67e-11 Atrial fibrillation; CESC cis rs798554 0.655 rs798492 chr7:2799184 C/T cg09658497 chr7:2847517 GNA12 0.33 5.11 0.3 6.3e-7 Height; CESC cis rs3126085 0.935 rs3120660 chr1:152258701 G/T cg03465714 chr1:152285911 FLG 0.46 5.74 0.33 2.61e-8 Atopic dermatitis; CESC cis rs858239 0.537 rs2286272 chr7:23224367 T/C cg23682824 chr7:23144976 KLHL7 0.45 5.85 0.34 1.46e-8 Cerebrospinal fluid biomarker levels; CESC cis rs6968419 0.755 rs3173919 chr7:115898177 G/C cg02561103 chr7:115862891 TES -0.41 -5.4 -0.31 1.51e-7 Intraocular pressure; CESC cis rs62064224 0.703 rs62065493 chr17:30822620 C/G cg09324608 chr17:30823087 MYO1D 0.5 7.61 0.42 4.96e-13 Schizophrenia; CESC cis rs28374715 0.662 rs28493087 chr15:41486504 G/A cg18705301 chr15:41695430 NDUFAF1 -0.81 -10.64 -0.55 3.12e-22 Ulcerative colitis; CESC cis rs67311347 0.544 rs1902073 chr3:40333497 C/T cg24209194 chr3:40518798 ZNF619 0.38 5.2 0.3 3.91e-7 Renal cell carcinoma; CESC cis rs7666738 0.546 rs10010088 chr4:98655945 C/T cg05340658 chr4:99064831 C4orf37 0.54 6.55 0.37 2.96e-10 Colonoscopy-negative controls vs population controls; CESC cis rs4523957 0.583 rs2760741 chr17:2020443 C/T cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg23048001 chr7:2026167 MAD1L1 0.46 6.04 0.35 5.3e-9 Schizophrenia; CESC cis rs3540 0.553 rs12592611 chr15:91004093 C/T cg10434728 chr15:90938212 IQGAP1 0.42 7.58 0.42 5.96e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs2455799 0.613 rs4684259 chr3:15791279 G/A cg09340198 chr3:15902540 ANKRD28 -0.33 -5.16 -0.3 4.94e-7 Mean platelet volume; CESC cis rs2933343 0.700 rs883602 chr3:128653952 A/G cg25356066 chr3:128598488 ACAD9 0.61 8.59 0.47 7.6e-16 IgG glycosylation; CESC cis rs9467711 0.606 rs9379899 chr6:26603015 T/A cg14345882 chr6:26364793 BTN3A2 0.56 5.96 0.34 7.82e-9 Autism spectrum disorder or schizophrenia; CESC cis rs1003719 1.000 rs2835608 chr21:38493455 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.54 0.46 1.1e-15 Eye color traits; CESC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg00431813 chr7:1051703 C7orf50 -0.35 -5.43 -0.32 1.26e-7 Longevity;Endometriosis; CESC cis rs2073300 1.000 rs6106656 chr20:23444301 A/G cg12062639 chr20:23401060 NAPB 0.77 5.68 0.33 3.48e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2273669 0.667 rs28504359 chr6:109330417 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs7789940 0.904 rs6953281 chr7:75946943 C/T cg10167463 chr7:75959203 YWHAG -0.51 -6.01 -0.35 6.11e-9 Multiple sclerosis; CESC cis rs4072980 0.524 rs16824514 chr1:38395947 A/T cg17077180 chr1:38461687 NA 0.42 6.04 0.35 5.16e-9 Coronary artery disease; CESC cis rs820218 0.926 rs820200 chr17:73632030 C/A cg01592526 chr17:73663357 RECQL5;SAP30BP 0.42 5.56 0.32 6.57e-8 Rotator cuff tears; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg13669089 chr11:31391497 DNAJC24;DCDC1 -0.45 -5.99 -0.35 6.63e-9 Height; CESC cis rs1707322 0.963 rs4630155 chr1:46257110 G/C cg06784218 chr1:46089804 CCDC17 0.37 6.37 0.36 8.49e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6582630 0.574 rs12146797 chr12:38436499 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.0 0.35 6.56e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs4835473 0.932 rs34917094 chr4:144753156 T/A cg25736465 chr4:144833511 NA -0.45 -6.75 -0.38 9.22e-11 Immature fraction of reticulocytes; CESC trans rs2727020 0.553 rs10839295 chr11:49527345 A/C cg03929089 chr4:120376271 NA -0.81 -12.21 -0.6 1.64e-27 Coronary artery disease; CESC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3820068 0.506 rs17448966 chr1:15990983 T/G cg16988262 chr1:15930761 NA 0.3 5.03 0.3 8.91e-7 Systolic blood pressure; CESC cis rs11583043 1.000 rs6700743 chr1:101447384 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 5.54 0.32 7.41e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.98 -11.2 -0.57 4.24e-24 Gut microbiome composition (summer); CESC cis rs12682352 0.715 rs332039 chr8:8723651 C/G cg15556689 chr8:8085844 FLJ10661 0.46 5.81 0.34 1.78e-8 Neuroticism; CESC cis rs3925075 1.000 rs3925074 chr16:31347807 G/A cg02846316 chr16:31340340 ITGAM 0.41 6.52 0.37 3.54e-10 IgA nephropathy; CESC cis rs71277158 0.688 rs76146702 chr3:169868720 G/T cg04067573 chr3:169899625 PHC3 0.71 7.11 0.4 1.08e-11 Prostate cancer; CESC cis rs7829975 0.514 rs2976926 chr8:8261624 T/C cg08975724 chr8:8085496 FLJ10661 0.4 5.1 0.3 6.54e-7 Mood instability; CESC cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg17366294 chr4:99064904 C4orf37 0.6 8.73 0.47 2.97e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.36 -6.49 -0.37 4.29e-10 Electroencephalogram traits; CESC cis rs2880765 0.743 rs6416598 chr15:86011848 G/A cg10818794 chr15:86012489 AKAP13 -0.35 -5.41 -0.32 1.42e-7 Coronary artery disease; CESC cis rs2050392 0.861 rs1042058 chr10:30728101 T/C cg25182066 chr10:30743637 MAP3K8 -0.43 -5.79 -0.33 2.04e-8 Inflammatory bowel disease; CESC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg22823121 chr1:150693482 HORMAD1 0.44 6.21 0.36 2.09e-9 Melanoma; CESC cis rs10170846 0.800 rs10180462 chr2:223526385 C/T cg25565276 chr2:223520875 FARSB 0.5 6.98 0.39 2.39e-11 Schizophrenia (inflammation and infection response interaction); CESC cis rs742614 0.533 rs13041078 chr20:32435497 G/T cg06304546 chr20:32448765 NA -0.41 -5.16 -0.3 4.85e-7 Stearic acid (18:0) levels; CESC cis rs7659604 0.967 rs34949254 chr4:122664344 G/A cg19671926 chr4:122722719 EXOSC9 -0.44 -5.22 -0.31 3.56e-7 Type 2 diabetes; CESC cis rs9611565 0.838 rs4239894 chr22:41745548 C/G cg17376030 chr22:41985996 PMM1 0.6 6.45 0.37 5.18e-10 Vitiligo; CESC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg19592336 chr6:28129416 ZNF389 0.58 7.71 0.43 2.54e-13 Depression; CESC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg18490616 chr2:88469792 THNSL2 -0.52 -7.76 -0.43 1.87e-13 Response to metformin (IC50); CESC cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.63 7.29 0.41 3.5e-12 Age-related macular degeneration (geographic atrophy); CESC cis rs7084402 0.967 rs7921207 chr10:60270235 G/T cg07615347 chr10:60278583 BICC1 -0.57 -8.71 -0.47 3.43e-16 Refractive error; CESC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg11890956 chr21:40555474 PSMG1 -0.67 -9.42 -0.5 2.35e-18 Menarche (age at onset); CESC cis rs2066819 1.000 rs77853814 chr12:56687572 G/T cg26734620 chr12:56694298 CS 0.97 5.99 0.35 6.91e-9 Psoriasis vulgaris; CESC cis rs10918270 1.000 rs10737521 chr1:161932193 C/T cg19735514 chr1:161762739 ATF6 -0.35 -5.24 -0.31 3.32e-7 Parkinson's disease (age of onset); CESC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -7.65 -0.43 3.81e-13 Personality dimensions; CESC cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg23711669 chr6:146136114 FBXO30 1.01 15.52 0.69 4.59e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs4700695 0.719 rs27082 chr5:65436152 A/C cg21114390 chr5:65439923 SFRS12 -0.52 -6.07 -0.35 4.47e-9 Facial morphology (factor 19); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12726807 chr15:41056075 GCHFR -0.53 -6.7 -0.38 1.27e-10 Ulcerative colitis; CESC cis rs1023500 0.573 rs133381 chr22:42470608 C/G cg12850546 chr22:42539477 CYP2D7P1 -0.45 -5.29 -0.31 2.59e-7 Schizophrenia; CESC cis rs2439831 0.681 rs3742969 chr15:43621947 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.94 0.56 3.23e-23 Lung cancer in ever smokers; CESC cis rs1348850 0.651 rs4893931 chr2:178228212 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.84 0.48 1.33e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.49 -0.5 1.38e-18 Alzheimer's disease; CESC cis rs72634258 0.891 rs404381 chr1:8080745 C/T cg25007680 chr1:8021821 PARK7 0.47 5.51 0.32 8.29e-8 Inflammatory bowel disease; CESC cis rs3096299 0.617 rs2353030 chr16:89405827 C/T cg08822215 chr16:89438651 ANKRD11 0.39 5.9 0.34 1.11e-8 Multiple myeloma (IgH translocation); CESC cis rs11997175 0.603 rs4291230 chr8:33674570 A/C ch.8.33884649F chr8:33765107 NA -0.5 -6.12 -0.35 3.39e-9 Body mass index; CESC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs9287719 0.810 rs7601748 chr2:10785446 A/G cg00105475 chr2:10696890 NA 0.36 5.15 0.3 5.01e-7 Prostate cancer; CESC trans rs11039798 0.502 rs961863 chr11:48417021 T/C cg15704280 chr7:45808275 SEPT13 -0.69 -6.81 -0.39 6.49e-11 Axial length; CESC cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.55 0.61 1.13e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg08499158 chr17:42289980 UBTF -0.53 -6.66 -0.38 1.59e-10 Total body bone mineral density; CESC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.02 0.4 1.85e-11 Bipolar disorder; CESC cis rs6032067 0.929 rs36032462 chr20:43873088 T/C cg10761708 chr20:43804764 PI3 0.52 6.17 0.35 2.53e-9 Blood protein levels; CESC cis rs921968 0.541 rs12619347 chr2:219419935 T/C cg02176678 chr2:219576539 TTLL4 -0.53 -9.38 -0.5 3.15e-18 Mean corpuscular hemoglobin concentration; CESC cis rs10883723 0.810 rs61873733 chr10:104251458 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.71 -0.33 2.98e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs4722166 0.695 rs35779989 chr7:22800314 A/C cg05265849 chr7:22767390 IL6 0.46 6.3 0.36 1.21e-9 Lung cancer; CESC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg01171360 chr6:293285 DUSP22 -0.67 -8.92 -0.48 8.07e-17 Menopause (age at onset); CESC cis rs7539409 0.651 rs6696140 chr1:84317468 C/T cg10977910 chr1:84465055 TTLL7 -0.75 -7.33 -0.41 2.8e-12 Alzheimer's disease; CESC cis rs1215050 0.704 rs783915 chr4:99023151 C/G cg17366294 chr4:99064904 C4orf37 0.42 5.51 0.32 8.51e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs11098499 0.954 rs10017371 chr4:120293776 A/G cg24375607 chr4:120327624 NA 0.46 5.62 0.33 4.77e-8 Corneal astigmatism; CESC cis rs9894429 0.789 rs7213849 chr17:79567610 C/T cg13777783 chr17:79615861 NA 0.34 5.36 0.31 1.82e-7 Eye color traits; CESC cis rs7312774 0.618 rs4964195 chr12:107392778 T/C cg16260113 chr12:107380972 MTERFD3 1.01 8.78 0.47 2.02e-16 Severe influenza A (H1N1) infection; CESC cis rs1558375 0.679 rs31676 chr7:87069880 T/C cg00919237 chr7:87102261 ABCB4 0.39 5.39 0.31 1.54e-7 Gallbladder cancer; CESC cis rs1005277 0.522 rs289643 chr10:37941494 T/G cg00409905 chr10:38381863 ZNF37A -0.48 -6.49 -0.37 4.26e-10 Extrinsic epigenetic age acceleration; CESC cis rs765787 0.530 rs1706832 chr15:45517173 C/T cg24006582 chr15:45444508 DUOX1 -0.6 -7.36 -0.41 2.35e-12 Uric acid levels; CESC cis rs7772486 0.875 rs9322044 chr6:146369608 T/C cg23711669 chr6:146136114 FBXO30 0.85 12.56 0.61 1.02e-28 Lobe attachment (rater-scored or self-reported); CESC trans rs3780486 0.846 rs10738905 chr9:33123627 A/G cg20290983 chr6:43655470 MRPS18A 0.98 18.2 0.75 1.44e-48 IgG glycosylation; CESC cis rs910316 1.000 rs12897094 chr14:75579416 C/T cg11812906 chr14:75593930 NEK9 0.89 15.42 0.69 9.8e-39 Height; CESC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.84 0.59 2.99e-26 Alzheimer's disease; CESC cis rs672059 1.000 rs1760621 chr1:183156006 T/G ch.1.3577855R chr1:183094577 LAMC1 0.52 6.75 0.38 9.41e-11 Hypertriglyceridemia; CESC cis rs10883723 0.810 rs12162 chr10:104240498 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.49 5.04 0.3 8.74e-7 Allergic disease (asthma, hay fever or eczema); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14242958 chr11:101785693 KIAA1377;ANGPTL5 -0.43 -6.09 -0.35 3.97e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg20476274 chr7:133979776 SLC35B4 0.6 8.32 0.45 4.79e-15 Mean platelet volume; CESC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg03647317 chr4:187891568 NA -0.38 -5.7 -0.33 3.21e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs17253792 0.732 rs79014965 chr14:56117551 T/G cg01858014 chr14:56050164 KTN1 -0.96 -7.52 -0.42 8.3e-13 Putamen volume; CESC cis rs11958404 1.000 rs72816527 chr5:157409633 C/T cg05962755 chr5:157440814 NA 0.56 6.1 0.35 3.82e-9 IgG glycosylation; CESC cis rs12136530 0.774 rs10799812 chr1:19770256 C/T cg01832549 chr1:19774989 CAPZB -0.48 -6.86 -0.39 4.71e-11 Lead levels in blood; CESC cis rs11583043 0.708 rs17123647 chr1:101529018 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.52 5.52 0.32 8.24e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs9900062 0.586 rs12600679 chr17:62687327 T/G cg02598441 chr17:62777298 LOC146880 -0.52 -5.56 -0.32 6.66e-8 QT interval; CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg26354017 chr1:205819088 PM20D1 0.93 16.67 0.72 3.8e-43 Menarche (age at onset); CESC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg09658497 chr7:2847517 GNA12 -0.37 -5.2 -0.3 4.04e-7 Height; CESC cis rs34779708 0.966 rs11010129 chr10:35510822 T/C cg04310649 chr10:35416472 CREM -0.54 -6.4 -0.37 6.97e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg04234412 chr22:24373322 LOC391322 0.53 7.63 0.42 4.11e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3820068 0.656 rs72645829 chr1:15889748 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.81 0.34 1.8e-8 Systolic blood pressure; CESC cis rs67311347 0.866 rs1454491 chr3:40352647 C/G cg24209194 chr3:40518798 ZNF619 0.42 5.36 0.31 1.79e-7 Renal cell carcinoma; CESC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg20887711 chr4:1340912 KIAA1530 0.59 8.21 0.45 1e-14 Longevity; CESC cis rs9581857 0.556 rs1885990 chr13:28040502 C/T cg01674679 chr13:27998804 GTF3A -0.54 -5.77 -0.33 2.2e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs4843747 0.671 rs9933794 chr16:88116981 T/C cg17633681 chr16:88106987 BANP 0.78 10.56 0.54 5.46e-22 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19138325 chr12:129429698 GLT1D1 -0.47 -6.97 -0.39 2.56e-11 Gut microbiota (bacterial taxa); CESC cis rs3820068 0.603 rs72647138 chr1:15980929 C/T cg16988262 chr1:15930761 NA 0.33 5.4 0.31 1.47e-7 Systolic blood pressure; CESC cis rs7843479 0.965 rs17581910 chr8:21799626 A/G cg17168535 chr8:21777572 XPO7 0.51 7.03 0.4 1.8e-11 Mean corpuscular volume; CESC cis rs5769707 0.632 rs135872 chr22:50009300 T/C cg20744362 chr22:50050164 C22orf34 0.38 5.44 0.32 1.24e-7 Monocyte count;Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14559409 chr10:65930703 NA -0.61 -7.29 -0.41 3.53e-12 Gut microbiome composition (summer); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg04391736 chr16:69373674 COG8;NIP7 -0.41 -6.35 -0.36 9.14e-10 Vertical cup-disc ratio; CESC cis rs1059312 1.000 rs1059312 chr12:129278864 A/G cg09035930 chr12:129282057 SLC15A4 -0.68 -9.25 -0.49 7.79e-18 Systemic lupus erythematosus; CESC cis rs6598955 0.627 rs6684875 chr1:26567044 A/G cg19743891 chr1:26644573 UBXN11;CD52 0.38 5.44 0.32 1.21e-7 Obesity-related traits; CESC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg11663144 chr21:46675770 NA -0.48 -7.25 -0.41 4.6e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg03433033 chr1:76189801 ACADM 0.68 8.23 0.45 8.33e-15 Blood metabolite levels;Acylcarnitine levels; CESC trans rs800888 0.772 rs10808475 chr8:116601071 A/G cg19047077 chr12:105044897 CHST11 0.46 6.01 0.35 6.11e-9 Monocyte percentage of white cells; CESC cis rs8077577 0.895 rs735960 chr17:18057301 G/A cg16794390 chr17:18148240 FLII 0.48 6.0 0.35 6.62e-9 Obesity-related traits; CESC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg06873352 chr17:61820015 STRADA -0.65 -11.01 -0.56 1.79e-23 Prudent dietary pattern; CESC cis rs6728642 1.000 rs7593754 chr2:97607544 C/T cg26665480 chr2:98280029 ACTR1B -0.64 -6.4 -0.37 7.14e-10 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs2637266 1.000 rs2130799 chr10:78322922 C/T cg18941641 chr10:78392320 NA 0.4 7.21 0.41 5.78e-12 Pulmonary function; CESC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg17971929 chr21:40555470 PSMG1 1.0 13.77 0.65 6.38e-33 Cognitive function; CESC cis rs10242455 0.681 rs2740559 chr7:99324515 G/C cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs950776 0.518 rs952216 chr15:78819202 C/T cg24631222 chr15:78858424 CHRNA5 -0.4 -5.2 -0.3 4.05e-7 Sudden cardiac arrest; CESC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg10691866 chr7:65817282 TPST1 -0.33 -5.43 -0.32 1.3e-7 Aortic root size; CESC cis rs7089973 0.624 rs10885614 chr10:116609098 C/T cg23260525 chr10:116636907 FAM160B1 0.4 7.2 0.4 6.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs698833 0.892 rs698801 chr2:44691662 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 6.18 0.35 2.4e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs911555 0.706 rs10129426 chr14:104018455 C/T cg12935359 chr14:103987150 CKB -0.44 -6.43 -0.37 6.02e-10 Intelligence (multi-trait analysis); CESC cis rs17666538 0.642 rs7821983 chr8:643696 A/G cg07234876 chr8:600039 NA 0.77 6.34 0.36 9.6e-10 IgG glycosylation; CESC cis rs2439831 1.000 rs2584726 chr15:43715382 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.86 10.51 0.54 7.92e-22 Lung cancer in ever smokers; CESC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.78 0.33 2.1e-8 Menopause (age at onset); CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg23978390 chr7:1156363 C7orf50 0.57 7.82 0.43 1.28e-13 Longevity;Endometriosis; CESC cis rs2243480 0.901 rs12530490 chr7:65691647 G/A cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs1008375 1.000 rs6854733 chr4:17640526 C/T cg16339924 chr4:17578868 LAP3 0.56 7.02 0.4 1.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3008870 1.000 rs2182143 chr1:67378936 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.05 14.57 0.67 9.8e-36 Lymphocyte percentage of white cells; CESC cis rs9300255 0.602 rs1727314 chr12:123640664 C/A cg05973401 chr12:123451056 ABCB9 0.5 5.81 0.34 1.79e-8 Neutrophil percentage of white cells; CESC cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg07636037 chr3:49044803 WDR6 1.07 19.81 0.77 3.34e-54 Parkinson's disease; CESC cis rs8072100 0.582 rs3826536 chr17:45501967 T/A cg08085267 chr17:45401833 C17orf57 -0.52 -6.6 -0.38 2.28e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs763121 0.853 rs2413547 chr22:39107338 A/G cg21395723 chr22:39101663 GTPBP1 0.43 5.45 0.32 1.13e-7 Menopause (age at onset); CESC cis rs6963495 0.872 rs73190193 chr7:105164852 A/G cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07194495 chr7:148958859 ZNF783 0.45 6.05 0.35 4.84e-9 Systemic lupus erythematosus; CESC cis rs3806843 1.000 rs6891995 chr5:140172008 A/G cg26395211 chr5:140044315 WDR55 -0.41 -5.26 -0.31 2.97e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7000551 0.751 rs1116084 chr8:22395309 C/T cg12081754 chr8:22256438 SLC39A14 0.4 5.05 0.3 8.1e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs9911578 0.967 rs57869245 chr17:57106630 A/G cg12560992 chr17:57184187 TRIM37 -0.94 -15.76 -0.7 6.18e-40 Intelligence (multi-trait analysis); CESC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg12288994 chr5:1860383 NA 0.41 6.9 0.39 3.75e-11 Cardiovascular disease risk factors; CESC cis rs919433 0.963 rs1429417 chr2:198158171 T/G cg10820045 chr2:198174542 NA -0.43 -6.58 -0.37 2.5e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7827545 1.000 rs1372660 chr8:135566788 C/G cg17885191 chr8:135476712 NA 0.48 6.28 0.36 1.35e-9 Hypertension (SNP x SNP interaction); CESC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg13395646 chr4:1353034 KIAA1530 -0.49 -6.25 -0.36 1.64e-9 Obesity-related traits; CESC cis rs6088580 0.524 rs6087616 chr20:33263033 T/C cg24642439 chr20:33292090 TP53INP2 -0.45 -5.33 -0.31 2.08e-7 Glomerular filtration rate (creatinine); CESC cis rs1008375 0.872 rs6831115 chr4:17640463 A/G cg02297831 chr4:17616191 MED28 0.57 7.34 0.41 2.67e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg19163074 chr7:65112434 INTS4L2 0.43 5.49 0.32 9.54e-8 Aortic root size; CESC cis rs6963495 0.769 rs73192134 chr7:105189338 T/C cg19920283 chr7:105172520 RINT1 0.67 6.32 0.36 1.11e-9 Bipolar disorder (body mass index interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22170962 chr19:57765336 ZNF805 -0.5 -6.09 -0.35 3.95e-9 Gut microbiome composition (summer); CESC cis rs6964587 0.869 rs55811257 chr7:91484799 T/A cg17063962 chr7:91808500 NA -0.52 -6.98 -0.39 2.42e-11 Breast cancer; CESC cis rs7584330 0.518 rs11888077 chr2:238424763 G/A cg14458575 chr2:238380390 NA 0.7 6.67 0.38 1.52e-10 Prostate cancer; CESC cis rs2742234 0.541 rs12416428 chr10:43708998 G/A cg07801480 chr10:43725741 RASGEF1A -0.41 -5.25 -0.31 3.08e-7 Hirschsprung disease; CESC cis rs17376456 1.000 rs9968691 chr5:93509756 C/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.04 0.3 8.6e-7 Diabetic retinopathy; CESC cis rs698833 0.886 rs1056865 chr2:44546741 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.73 0.33 2.72e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs10392 0.516 rs3752293 chr20:37570725 A/G cg27552599 chr20:37590471 DHX35 -0.37 -5.49 -0.32 9.55e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs78456975 0.527 rs7590742 chr2:1575049 A/T cg26248373 chr2:1572462 NA -0.59 -6.93 -0.39 3.22e-11 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs12956009 0.583 rs35970525 chr18:44882625 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.59 0.38 2.42e-10 Educational attainment (years of education); CESC cis rs2070488 0.775 rs7644530 chr3:38558316 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.78 -12.57 -0.61 1.01e-28 Electrocardiographic conduction measures; CESC trans rs61931739 0.500 rs11053260 chr12:34530215 T/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 8.03e-13 Morning vs. evening chronotype; CESC cis rs4728302 0.869 rs6955279 chr7:133612113 C/T cg10665199 chr7:133106180 EXOC4 0.42 5.73 0.33 2.74e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs2228479 0.867 rs62052187 chr16:89973071 G/A cg06558623 chr16:89946397 TCF25 0.9 7.95 0.44 5.37e-14 Skin colour saturation; CESC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg18876405 chr7:65276391 NA -0.55 -7.1 -0.4 1.11e-11 Aortic root size; CESC cis rs6831352 0.734 rs12502237 chr4:100015675 G/A cg13256891 chr4:100009986 ADH5 0.69 8.17 0.45 1.29e-14 Alcohol dependence; CESC cis rs7916697 0.947 rs1900004 chr10:70000881 C/T cg06988349 chr10:69991859 ATOH7 0.37 6.34 0.36 9.66e-10 Optic disc area; CESC cis rs9549260 0.816 rs9532582 chr13:41251207 A/G cg21288729 chr13:41239152 FOXO1 0.64 8.18 0.45 1.19e-14 Red blood cell count; CESC trans rs8073060 0.559 rs17550632 chr17:33890883 G/C cg19694781 chr19:47549865 TMEM160 0.75 7.01 0.4 2.01e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7100689 0.646 rs12253992 chr10:82158710 G/A cg00277334 chr10:82204260 NA -0.46 -6.31 -0.36 1.19e-9 Post bronchodilator FEV1; CESC cis rs36051895 0.658 rs10975029 chr9:5251068 T/C cg02405213 chr9:5042618 JAK2 -0.48 -5.8 -0.34 1.86e-8 Pediatric autoimmune diseases; CESC cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg16339924 chr4:17578868 LAP3 0.64 7.83 0.43 1.21e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9287719 0.967 rs6751398 chr2:10738972 T/C cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC trans rs1557351 0.723 rs9949903 chr18:54722522 A/G cg11433624 chr6:7146702 RREB1 0.38 6.14 0.35 2.94e-9 Multiple sclerosis (age of onset); CESC cis rs6502050 0.805 rs62080003 chr17:80078957 C/T cg23985595 chr17:80112537 CCDC57 0.41 6.54 0.37 3.19e-10 Life satisfaction; CESC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg24296786 chr1:45957014 TESK2 0.68 9.37 0.5 3.33e-18 High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26316544 chr3:52188418 WDR51A 0.59 6.78 0.38 7.88e-11 Gut microbiome composition (summer); CESC cis rs6540556 0.723 rs6540550 chr1:209925251 A/G cg05527609 chr1:210001259 C1orf107 -0.46 -5.66 -0.33 3.89e-8 Red blood cell count; CESC cis rs8114671 0.662 rs6058146 chr20:33540529 A/G cg24642439 chr20:33292090 TP53INP2 0.43 5.07 0.3 7.34e-7 Height; CESC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg26732615 chr19:19648335 CILP2;YJEFN3 -0.45 -5.89 -0.34 1.19e-8 Tonsillectomy; CESC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.67 0.33 3.69e-8 Bipolar disorder; CESC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg17221315 chr6:27791827 HIST1H4J 0.45 5.74 0.33 2.53e-8 Parkinson's disease; CESC cis rs7561273 0.609 rs2339945 chr2:24348096 G/A cg20701182 chr2:24300061 SF3B14 0.46 6.01 0.35 6.27e-9 Quantitative traits; CESC cis rs864537 0.622 rs1214598 chr1:167426424 C/T cg09179987 chr1:167433047 CD247 0.52 7.89 0.44 8.24e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.63 7.73 0.43 2.2e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7107174 1.000 rs2450128 chr11:77940075 G/A cg02023728 chr11:77925099 USP35 0.46 6.7 0.38 1.22e-10 Testicular germ cell tumor; CESC cis rs3733585 0.699 rs7686538 chr4:9948077 C/T cg02734326 chr4:10020555 SLC2A9 -0.42 -5.84 -0.34 1.51e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs654950 0.934 rs653369 chr1:42002376 A/T cg06885757 chr1:42089581 HIVEP3 -0.68 -10.85 -0.55 6.07e-23 Airway imaging phenotypes; CESC cis rs1153858 1.000 rs12440038 chr15:45706739 A/G cg14582100 chr15:45693742 SPATA5L1 0.41 5.79 0.33 2.03e-8 Homoarginine levels; CESC cis rs736801 0.521 rs2070729 chr5:131819921 G/T cg00255919 chr5:131827918 IRF1 0.37 6.35 0.36 9.43e-10 Breast cancer;Mosquito bite size; CESC trans rs11638815 0.639 rs783542 chr15:83236014 G/C cg25333056 chr10:135107159 TUBGCP2 0.5 6.02 0.35 5.92e-9 Lipoprotein-associated phospholipase A2 activity change in response to statin therapy; CESC cis rs933688 0.941 rs2887007 chr5:90740531 A/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.06 13.34 0.63 2.14e-31 Smoking behavior; CESC cis rs56104184 0.775 rs73061692 chr19:49399676 T/C cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs2797160 0.651 rs1268093 chr6:126029235 C/T cg05039488 chr6:79577232 IRAK1BP1 0.48 6.54 0.37 3.22e-10 Endometrial cancer; CESC trans rs7307889 0.793 rs55783865 chr12:6013681 G/A cg18407955 chr7:158110685 PTPRN2 -0.72 -6.68 -0.38 1.41e-10 Obesity-related traits; CESC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.56 7.21 0.41 5.75e-12 Prudent dietary pattern; CESC cis rs9443189 0.570 rs504323 chr6:76294965 A/G cg01950844 chr6:76311363 SENP6 -0.86 -8.27 -0.45 6.58e-15 Prostate cancer; CESC cis rs9359856 0.510 rs3736984 chr6:90408589 C/T cg13799429 chr6:90582589 CASP8AP2 0.73 8.3 0.45 5.19e-15 Bipolar disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14630947 chr20:47894888 C20orf199;ZNFX1;SNORD12C -0.52 -6.44 -0.37 5.52e-10 Ulcerative colitis; CESC cis rs888194 0.649 rs10774697 chr12:109875981 A/G cg19025524 chr12:109796872 NA -0.41 -6.24 -0.36 1.75e-9 Neuroticism; CESC cis rs11864453 0.647 rs8043606 chr16:72135319 T/C cg16558253 chr16:72132732 DHX38 -0.54 -8.44 -0.46 2.04e-15 Fibrinogen levels; CESC cis rs3749237 0.576 rs3877784 chr3:49539417 C/T cg03060546 chr3:49711283 APEH 0.77 11.82 0.59 3.5e-26 Resting heart rate; CESC cis rs7586879 1.000 rs7603153 chr2:25116966 T/C cg01884057 chr2:25150051 NA 0.28 5.12 0.3 5.86e-7 Body mass index; CESC cis rs9457247 0.565 rs55873403 chr6:167511800 C/T cg23791538 chr6:167370224 RNASET2 -0.53 -6.98 -0.39 2.32e-11 Crohn's disease; CESC cis rs2243480 1.000 rs6966322 chr7:65646754 A/G cg12463550 chr7:65579703 CRCP -0.73 -5.66 -0.33 4.03e-8 Diabetic kidney disease; CESC cis rs2952156 0.920 rs2941506 chr17:37833035 A/G cg00129232 chr17:37814104 STARD3 -0.74 -10.19 -0.53 8.45e-21 Asthma; CESC cis rs1348850 0.539 rs1453371 chr2:178227862 T/G cg23306229 chr2:178417860 TTC30B 0.48 5.96 0.34 8.03e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12968172 chr2:239112248 ILKAP 0.57 6.51 0.37 3.71e-10 Gut microbiome composition (summer); CESC cis rs735860 0.712 rs9395855 chr6:53176765 G/T cg10236188 chr6:53219634 NA -0.35 -5.14 -0.3 5.28e-7 Glaucoma; CESC cis rs9916302 0.645 rs1053651 chr17:37822311 A/C cg07936489 chr17:37558343 FBXL20 -0.54 -6.58 -0.37 2.52e-10 Glomerular filtration rate (creatinine); CESC cis rs2832191 0.626 rs2254796 chr21:30341891 A/G cg24692254 chr21:30365293 RNF160 -0.93 -15.77 -0.7 5.57e-40 Dental caries; CESC cis rs4711336 1.000 rs4711337 chr6:33659987 T/C cg14003231 chr6:33640908 ITPR3 0.32 5.42 0.32 1.34e-7 Height; CESC cis rs4604732 0.642 rs4266925 chr1:247639165 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.46 6.57 0.37 2.64e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs36051895 0.623 rs72703608 chr9:5258127 A/G cg02405213 chr9:5042618 JAK2 -0.55 -6.12 -0.35 3.44e-9 Pediatric autoimmune diseases; CESC cis rs2115630 0.645 rs3825877 chr15:85174631 G/A cg12501888 chr15:85177176 SCAND2 -0.48 -6.34 -0.36 9.89e-10 P wave terminal force; CESC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg21951975 chr1:209979733 IRF6 0.63 7.76 0.43 1.86e-13 Cleft lip with or without cleft palate; CESC trans rs634534 0.561 rs14157 chr11:65769780 T/G cg17712092 chr4:129076599 LARP1B 0.73 10.25 0.53 5.63e-21 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs763121 0.853 rs2413547 chr22:39107338 A/G cg06544989 chr22:39130855 UNC84B 0.51 8.87 0.48 1.07e-16 Menopause (age at onset); CESC cis rs2228479 0.850 rs17226966 chr16:89825338 A/G cg00800038 chr16:89945340 TCF25 -0.92 -7.67 -0.43 3.37e-13 Skin colour saturation; CESC cis rs425277 0.583 rs3128334 chr1:2038662 G/A cg16545954 chr1:2118288 C1orf86 -0.35 -6.69 -0.38 1.33e-10 Height; CESC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 11.36 0.57 1.25e-24 Platelet count; CESC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg25036284 chr2:26402008 FAM59B -0.58 -6.77 -0.38 8.35e-11 Gut microbiome composition (summer); CESC cis rs9926296 0.643 rs2159114 chr16:89831841 A/G cg04287289 chr16:89883240 FANCA 0.59 7.67 0.43 3.2e-13 Vitiligo; CESC cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg27347728 chr4:17578864 LAP3 0.49 5.56 0.32 6.68e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2463822 1.000 rs2463821 chr11:62111662 T/C cg06239285 chr11:62104954 ASRGL1 0.98 8.74 0.47 2.74e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2073300 0.609 rs6137948 chr20:23416845 G/A cg12062639 chr20:23401060 NAPB 1.05 8.13 0.45 1.7e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9291683 0.552 rs11736410 chr4:10017241 G/A cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.5e-12 Bone mineral density; CESC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg24675658 chr1:53192096 ZYG11B 0.58 7.97 0.44 4.88e-14 Monocyte count; CESC cis rs3857067 1.000 rs1904094 chr4:95012459 A/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg26314531 chr2:26401878 FAM59B -0.84 -9.15 -0.49 1.62e-17 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg05340658 chr4:99064831 C4orf37 0.78 11.94 0.59 1.39e-26 Colonoscopy-negative controls vs population controls; CESC cis rs7937682 0.883 rs510388 chr11:111451869 G/T cg09085632 chr11:111637200 PPP2R1B 0.86 12.9 0.62 6.92e-30 Primary sclerosing cholangitis; CESC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg07090678 chr1:91966139 CDC7 0.41 5.63 0.33 4.52e-8 Breast cancer; CESC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg04756594 chr16:24857601 SLC5A11 0.49 5.99 0.35 6.68e-9 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg25072359 chr17:41440525 NA 0.46 6.21 0.36 2.04e-9 Menopause (age at onset); CESC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg00106254 chr7:1943704 MAD1L1 -0.5 -6.25 -0.36 1.67e-9 Bipolar disorder and schizophrenia; CESC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg18225595 chr11:63971243 STIP1 0.52 5.13 0.3 5.55e-7 Mean platelet volume; CESC cis rs921968 0.643 rs586374 chr2:219383003 A/C cg02176678 chr2:219576539 TTLL4 0.43 7.69 0.43 2.95e-13 Mean corpuscular hemoglobin concentration; CESC cis rs11997175 0.524 rs12164218 chr8:33669658 G/C ch.8.33884649F chr8:33765107 NA 0.51 6.22 0.36 1.97e-9 Body mass index; CESC cis rs941408 0.515 rs7253128 chr19:2776982 C/T cg06609049 chr19:2785107 THOP1 0.88 13.46 0.64 7.89e-32 Total cholesterol levels; CESC cis rs10197940 0.624 rs6731486 chr2:152410732 C/T cg19508488 chr2:152266495 RIF1 -0.5 -5.98 -0.34 7.14e-9 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.4.2917740F chr4:159758027 FNIP2 -0.54 -6.04 -0.35 5.1e-9 Gut microbiome composition (summer); CESC trans rs11098499 0.863 rs6534141 chr4:120485223 A/T cg25214090 chr10:38739885 LOC399744 0.67 9.14 0.49 1.7e-17 Corneal astigmatism; CESC cis rs1062753 0.922 rs9611712 chr22:42410993 T/C cg22189786 chr22:42395067 WBP2NL 0.42 5.24 0.31 3.29e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs397969 0.570 rs62066349 chr17:19899940 C/G cg12073167 chr17:19770448 ULK2 -0.47 -5.34 -0.31 2.04e-7 Platelet count; CESC cis rs3857536 0.740 rs4710572 chr6:66890361 C/A cg07460842 chr6:66804631 NA -0.41 -5.36 -0.31 1.82e-7 Blood trace element (Cu levels); CESC cis rs4919087 0.715 rs8181326 chr10:98998195 G/A cg25902810 chr10:99078978 FRAT1 0.58 7.81 0.43 1.31e-13 Monocyte count; CESC cis rs796364 0.806 rs10445792 chr2:201078821 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.75 -6.26 -0.36 1.54e-9 Schizophrenia; CESC trans rs61931739 0.500 rs10772160 chr12:34456848 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.5 0.42 9.79e-13 Morning vs. evening chronotype; CESC cis rs3749237 0.595 rs11130192 chr3:49467206 C/G cg06212747 chr3:49208901 KLHDC8B 0.49 6.53 0.37 3.25e-10 Resting heart rate; CESC cis rs2425143 1.000 rs2295356 chr20:34252856 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -7.54 -0.42 7.65e-13 Blood protein levels; CESC cis rs7044106 0.762 rs12003646 chr9:123470621 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.34 5.16 0.3 4.83e-7 Hip circumference adjusted for BMI; CESC trans rs2867695 0.590 rs11727456 chr4:81181908 C/T cg01943478 chr2:176032600 ATF2;MIR933 -0.73 -6.24 -0.36 1.71e-9 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs2732480 0.577 rs2732466 chr12:48732459 A/G cg04545296 chr12:48745243 ZNF641 0.44 7.24 0.41 4.8e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7078219 0.543 rs7092009 chr10:101277239 A/G cg09788492 chr10:101292477 NKX2-3 0.32 6.0 0.35 6.52e-9 Dental caries; CESC cis rs763121 0.853 rs6001182 chr22:39047443 A/G cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23086892 chr6:38670856 GLO1 0.56 6.17 0.35 2.55e-9 Gut microbiome composition (summer); CESC cis rs11864453 0.963 rs7185215 chr16:72034864 T/C cg01557791 chr16:72042693 DHODH -0.66 -9.0 -0.48 4.38e-17 Fibrinogen levels; CESC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -5.93 -0.34 9.49e-9 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15193461 chr17:42977049 CCDC103;EFTUD2 -0.46 -6.28 -0.36 1.42e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg17949981 chr6:28129498 ZNF389 0.42 5.24 0.31 3.27e-7 Depression; CESC cis rs6701037 0.625 rs67332874 chr1:175128537 G/A cg00321850 chr1:175162397 KIAA0040 -0.43 -6.2 -0.36 2.1e-9 Alcohol dependence; CESC trans rs1814175 0.727 rs2140597 chr11:49873946 G/A cg03929089 chr4:120376271 NA -0.91 -15.11 -0.68 1.3e-37 Height; CESC cis rs3862030 0.503 rs10786673 chr10:104280537 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.59 0.42 5.46e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg15445000 chr17:37608096 MED1 0.41 6.83 0.39 5.8200000000000003e-11 Glomerular filtration rate (creatinine); CESC cis rs6540559 0.611 rs11810817 chr1:210011747 C/G cg25204440 chr1:209979598 IRF6 0.53 5.23 0.31 3.44e-7 Cleft lip with or without cleft palate; CESC trans rs60380162 0.963 rs58458824 chr1:87726966 G/C cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.0 -0.35 6.5e-9 Loneliness (linear analysis); CESC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg12310025 chr6:25882481 NA -0.6 -9.19 -0.49 1.22e-17 Blood metabolite levels; CESC cis rs12497850 0.864 rs4521268 chr3:49137904 G/T cg03060546 chr3:49711283 APEH 0.52 6.34 0.36 1e-9 Parkinson's disease; CESC cis rs1023500 0.573 rs6002592 chr22:42476754 A/C cg12850546 chr22:42539477 CYP2D7P1 0.43 5.12 0.3 5.88e-7 Schizophrenia; CESC cis rs11122272 0.701 rs11582413 chr1:231530098 C/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs258892 0.894 rs155435 chr5:72200093 G/A cg21869765 chr5:72125136 TNPO1 0.45 5.62 0.33 4.9e-8 Small cell lung carcinoma; CESC cis rs34779708 0.931 rs66887762 chr10:35330577 C/T cg04310649 chr10:35416472 CREM -0.5 -5.96 -0.34 7.83e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg11494091 chr17:61959527 GH2 0.71 12.56 0.61 1.05e-28 Prudent dietary pattern; CESC cis rs2549003 1.000 rs2070723 chr5:131823187 A/G cg00255919 chr5:131827918 IRF1 0.51 8.51 0.46 1.26e-15 Asthma (sex interaction); CESC cis rs7824557 0.628 rs6601580 chr8:11193736 T/G cg21775007 chr8:11205619 TDH 0.55 8.74 0.47 2.75e-16 Retinal vascular caliber; CESC cis rs2742234 1.000 rs1864399 chr10:43610455 T/C cg15436174 chr10:43711423 RASGEF1A -0.41 -5.08 -0.3 7.03e-7 Hirschsprung disease; CESC cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg13877915 chr19:58951672 ZNF132 0.39 5.81 0.34 1.83e-8 Uric acid clearance; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg21014120 chr2:203736523 ICA1L -0.45 -6.49 -0.37 4.28e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs9650657 0.537 rs4841457 chr8:10773511 T/G cg06636001 chr8:8085503 FLJ10661 -0.57 -7.31 -0.41 3.1e-12 Neuroticism; CESC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg27170947 chr2:26402098 FAM59B -0.57 -6.75 -0.38 9.46e-11 Gut microbiome composition (summer); CESC cis rs2635047 1.000 rs2635043 chr18:44679769 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.8 0.39 7.02e-11 Educational attainment; CESC cis rs66573146 0.561 rs67245546 chr4:6947164 T/C cg26116260 chr4:7069785 GRPEL1 -0.83 -5.11 -0.3 6.23e-7 Granulocyte percentage of myeloid white cells; CESC cis rs10129255 0.912 rs6576227 chr14:107186441 A/G cg07958169 chr14:107095056 NA -0.42 -5.87 -0.34 1.28e-8 Kawasaki disease; CESC cis rs258892 0.895 rs6871969 chr5:72085036 C/T cg21869765 chr5:72125136 TNPO1 -0.42 -5.42 -0.32 1.36e-7 Small cell lung carcinoma; CESC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.36 0.57 1.3e-24 Alzheimer's disease; CESC cis rs2549003 0.934 rs2549006 chr5:131827065 A/G cg00255919 chr5:131827918 IRF1 -0.6 -10.0 -0.52 3.52e-20 Asthma (sex interaction); CESC cis rs8067354 0.574 rs2526358 chr17:57942585 A/G cg13753209 chr17:57696993 CLTC 0.54 5.67 0.33 3.75e-8 Hemoglobin concentration; CESC cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg04478727 chr12:58166393 METTL1;FAM119B 0.73 9.4 0.5 2.63e-18 Multiple sclerosis; CESC cis rs116095464 0.558 rs10060089 chr5:205565 G/A cg16372103 chr5:203701 NA 0.49 5.29 0.31 2.6e-7 Breast cancer; CESC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg24829409 chr8:58192753 C8orf71 -0.78 -10.21 -0.53 7.21e-21 Developmental language disorder (linguistic errors); CESC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg24503407 chr1:205819492 PM20D1 0.81 12.58 0.61 9.28e-29 Menarche (age at onset); CESC cis rs1595825 0.891 rs6733834 chr2:198518709 C/G cg10820045 chr2:198174542 NA -0.43 -5.44 -0.32 1.24e-7 Ulcerative colitis; CESC cis rs2011503 1.000 rs80200208 chr19:19554725 C/T cg11584989 chr19:19387371 SF4 0.62 7.22 0.41 5.54e-12 Bipolar disorder; CESC trans rs11098499 0.863 rs17050695 chr4:120489527 G/T cg25214090 chr10:38739885 LOC399744 0.64 8.52 0.46 1.23e-15 Corneal astigmatism; CESC cis rs2979489 0.773 rs10954993 chr8:30303388 C/T cg26383811 chr8:30366931 RBPMS 0.82 9.85 0.52 1.02e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs2286503 0.780 rs1304431 chr7:22865412 T/C cg13679077 chr7:22862647 TOMM7 0.52 6.78 0.38 7.96e-11 Fibrinogen; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06883736 chr1:182992627 LAMC1 0.55 6.18 0.35 2.41e-9 Gut microbiome composition (summer); CESC cis rs798766 1.000 rs4865463 chr4:1742400 T/C cg07041428 chr4:1763019 NA -0.4 -5.67 -0.33 3.75e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg00684032 chr4:1343700 KIAA1530 0.41 5.77 0.33 2.22e-8 Obesity-related traits; CESC cis rs7000551 0.532 rs4872486 chr8:22256359 G/T cg12081754 chr8:22256438 SLC39A14 0.84 12.46 0.61 2.34e-28 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs7149337 0.805 rs4350491 chr14:51675798 A/G cg23942311 chr14:51606299 NA 0.45 7.55 0.42 6.84e-13 Cancer; CESC cis rs8114671 0.562 rs34837802 chr20:33424908 C/G cg06115741 chr20:33292138 TP53INP2 0.43 5.26 0.31 2.94e-7 Height; CESC cis rs10883723 0.810 rs13287 chr10:104240438 A/G ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.25 0.31 3.18e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs72781680 0.611 rs72797810 chr2:24336469 G/A cg08917208 chr2:24149416 ATAD2B 0.56 5.49 0.32 9.59e-8 Lymphocyte counts; CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg18404041 chr3:52824283 ITIH1 -0.36 -6.52 -0.37 3.61e-10 Electroencephalogram traits; CESC cis rs36051895 0.632 rs72701654 chr9:5161453 T/C cg02405213 chr9:5042618 JAK2 -0.49 -5.53 -0.32 7.59e-8 Pediatric autoimmune diseases; CESC cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg11644478 chr21:40555479 PSMG1 0.59 8.09 0.44 2.2e-14 Cognitive function; CESC cis rs8099014 0.559 rs9319928 chr18:56099996 T/G cg12827950 chr18:55968429 NEDD4L -0.53 -5.66 -0.33 3.92e-8 Platelet count; CESC cis rs6736093 0.897 rs4848874 chr2:112681500 A/G cg12686935 chr2:112915763 FBLN7 -0.44 -5.72 -0.33 2.86e-8 Coronary artery disease; CESC cis rs2204008 0.715 rs11514342 chr12:38236710 T/A cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.52 1.51e-19 Bladder cancer; CESC cis rs1707322 1.000 rs7527079 chr1:46413450 C/G cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04928513 chr20:60717545 PSMA7;SS18L1 -0.57 -6.62 -0.38 2e-10 Gut microbiome composition (summer); CESC cis rs929354 0.713 rs10085650 chr7:156993413 T/C cg05182265 chr7:156933206 UBE3C -0.51 -7.42 -0.41 1.57e-12 Body mass index; CESC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg03647317 chr4:187891568 NA -0.38 -5.33 -0.31 2.09e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs1355223 0.506 rs1828299 chr11:34870418 T/C cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.64 -0.38 1.81e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs8017423 0.647 rs4904680 chr14:90822075 C/T cg14092571 chr14:90743983 NA 0.44 6.82 0.39 6.11e-11 Mortality in heart failure; CESC cis rs7208859 0.614 rs216412 chr17:28903394 A/G cg14008862 chr17:28927542 LRRC37B2 -0.67 -6.44 -0.37 5.67e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6681460 0.966 rs10789214 chr1:67146817 C/T cg02459107 chr1:67143332 SGIP1 0.38 5.25 0.31 3.1e-7 Presence of antiphospholipid antibodies; CESC cis rs2479106 0.549 rs1928482 chr9:126432448 T/C cg16191174 chr9:126692580 DENND1A 0.4 5.7 0.33 3.21e-8 Polycystic ovary syndrome; CESC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg00149659 chr3:10157352 C3orf10 0.57 7.1 0.4 1.17e-11 Alzheimer's disease; CESC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg06028808 chr11:68637592 NA 0.43 5.12 0.3 5.87e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg08499158 chr17:42289980 UBTF -0.51 -6.52 -0.37 3.47e-10 Total body bone mineral density; CESC cis rs6942756 0.876 rs822039 chr7:129065774 A/G cg02491457 chr7:128862824 NA -0.52 -7.07 -0.4 1.4e-11 White matter hyperintensity burden; CESC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg23048001 chr7:2026167 MAD1L1 0.41 5.27 0.31 2.89e-7 Bipolar disorder and schizophrenia; CESC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg11494091 chr17:61959527 GH2 0.73 12.57 0.61 1e-28 Prudent dietary pattern; CESC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.01 9.85 0.52 1.05e-19 Platelet count; CESC cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.82e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs7726839 0.507 rs111707179 chr5:593308 T/A cg25482853 chr8:67687455 SGK3 1.03 9.89 0.52 7.86e-20 Obesity-related traits; CESC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg12667521 chr19:29218732 NA 0.47 6.25 0.36 1.64e-9 Methadone dose in opioid dependence; CESC cis rs35146811 0.844 rs4729576 chr7:99692594 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.48 5.88 0.34 1.2e-8 Coronary artery disease; CESC cis rs3008870 0.920 rs1925413 chr1:67417101 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.04 14.53 0.67 1.38e-35 Lymphocyte percentage of white cells; CESC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg06108461 chr20:60628389 TAF4 -0.8 -11.58 -0.58 2.38e-25 Body mass index; CESC cis rs10992471 0.756 rs11792342 chr9:95143668 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -5.68 -0.33 3.52e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC trans rs561341 1.000 rs550264 chr17:30317540 G/T cg27661571 chr11:113659931 NA -0.83 -7.7 -0.43 2.79e-13 Hip circumference adjusted for BMI; CESC cis rs12410462 0.681 rs115956039 chr1:227661978 G/A cg23173402 chr1:227635558 NA 0.71 6.11 0.35 3.57e-9 Major depressive disorder; CESC cis rs8005677 1.000 rs7155857 chr14:23400059 C/A cg25600027 chr14:23388339 RBM23 -0.43 -5.24 -0.31 3.22e-7 Cognitive ability (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23663318 chr1:89448407 RBMXL1;CCBL2 -0.5 -6.22 -0.36 1.88e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17823076 chr12:53574937 ZNF740;CSAD 0.6 7.1 0.4 1.13e-11 Gut microbiome composition (summer); CESC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg24110177 chr3:50126178 RBM5 -0.5 -6.95 -0.39 2.83e-11 Body mass index; CESC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg12463550 chr7:65579703 CRCP -0.5 -6.32 -0.36 1.08e-9 Aortic root size; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20273774 chr5:180671298 GNB2L1;SNORD95 -0.45 -6.06 -0.35 4.67e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08648346 chr2:95825642 ZNF514 0.61 6.73 0.38 1.04e-10 Gut microbiome composition (summer); CESC cis rs2952156 0.959 rs2517956 chr17:37843859 G/A cg00129232 chr17:37814104 STARD3 -0.72 -9.44 -0.5 2e-18 Asthma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24583131 chr6:18265189 DEK 0.5 6.6 0.38 2.2e-10 Gut microbiota (bacterial taxa); CESC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg02951883 chr7:2050386 MAD1L1 -0.56 -7.4 -0.41 1.75e-12 Bipolar disorder and schizophrenia; CESC cis rs9926296 0.744 rs154657 chr16:89708096 A/G cg27121462 chr16:89883253 FANCA 0.45 5.37 0.31 1.74e-7 Vitiligo; CESC trans rs561341 1.000 rs497479 chr17:30328605 C/T cg27661571 chr11:113659931 NA -0.8 -7.58 -0.42 5.95e-13 Hip circumference adjusted for BMI; CESC cis rs7678296 1.000 rs73142714 chr4:37179884 G/A cg06805348 chr4:37245195 KIAA1239 0.44 5.12 0.3 5.78e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs6456156 0.586 rs6456150 chr6:167468922 A/G cg23791538 chr6:167370224 RNASET2 -0.5 -6.46 -0.37 4.9e-10 Primary biliary cholangitis; CESC cis rs7647973 0.626 rs1996663 chr3:49878264 C/G cg03060546 chr3:49711283 APEH -0.62 -7.59 -0.42 5.49e-13 Menarche (age at onset); CESC cis rs4450798 0.649 rs9845991 chr3:13778031 C/A cg23332027 chr3:13681764 NA 0.38 5.2 0.3 4.01e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs564309 0.681 rs2230656 chr1:228612838 G/T cg13771378 chr1:228613100 HIST3H3 0.54 5.22 0.31 3.57e-7 Hip circumference (psychosocial stress interaction); CESC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg23758822 chr17:41437982 NA 1.02 15.37 0.69 1.45e-38 Menopause (age at onset); CESC cis rs921968 0.541 rs12987171 chr2:219327030 G/C cg02176678 chr2:219576539 TTLL4 0.5 8.91 0.48 8.53e-17 Mean corpuscular hemoglobin concentration; CESC cis rs6831352 0.703 rs2602854 chr4:100028651 C/T cg13256891 chr4:100009986 ADH5 0.7 8.18 0.45 1.19e-14 Alcohol dependence; CESC trans rs11098499 0.954 rs10518328 chr4:120401779 G/A cg25214090 chr10:38739885 LOC399744 0.72 10.09 0.53 1.79e-20 Corneal astigmatism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04048796 chr4:57301372 PAICS;PPAT -0.45 -6.23 -0.36 1.87e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11971779 0.816 rs11979272 chr7:139074069 C/T cg07862535 chr7:139043722 LUC7L2 0.56 5.65 0.33 4.1e-8 Diisocyanate-induced asthma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05296608 chr10:134537282 INPP5A 0.47 6.43 0.37 5.87e-10 Fibrinogen levels; CESC cis rs909674 0.775 rs4821896 chr22:39833437 T/C cg11247378 chr22:39784982 NA -0.58 -8.49 -0.46 1.53e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg18876405 chr7:65276391 NA -0.55 -7.55 -0.42 7.19e-13 Aortic root size; CESC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.77 -0.33 2.2e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs116095464 0.558 rs62347677 chr5:227453 A/G cg22857025 chr5:266934 NA -1.27 -18.49 -0.75 1.32e-49 Breast cancer; CESC cis rs2066819 1.000 rs58852079 chr12:56706922 A/C cg26714650 chr12:56694279 CS -1.48 -9.9 -0.52 7.03e-20 Psoriasis vulgaris; CESC cis rs6539267 0.741 rs35816179 chr12:106693710 T/C cg02476566 chr12:106696527 TCP11L2 0.58 6.84 0.39 5.59e-11 Tourette syndrome; CESC trans rs8073060 0.544 rs7210966 chr17:33986334 G/C cg19694781 chr19:47549865 TMEM160 -0.75 -7.42 -0.41 1.55e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7824557 0.872 rs2572431 chr8:11105077 C/T cg21775007 chr8:11205619 TDH -0.39 -5.72 -0.33 2.82e-8 Retinal vascular caliber; CESC cis rs16854884 0.632 rs35716467 chr3:143684993 C/A cg06585982 chr3:143692056 C3orf58 0.53 7.02 0.4 1.83e-11 Economic and political preferences (feminism/equality); CESC cis rs6009527 0.963 rs6009532 chr22:49572757 C/G cg12746016 chr22:49560550 NA 0.34 5.32 0.31 2.25e-7 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); CESC cis rs2635047 0.935 rs2461247 chr18:44698537 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.47 6.36 0.36 8.56e-10 Educational attainment; CESC cis rs35306767 0.953 rs35174953 chr10:961191 C/A cg10556349 chr10:835070 NA 0.57 6.07 0.35 4.29e-9 Eosinophil percentage of granulocytes; CESC cis rs12824058 0.831 rs4759657 chr12:130815818 G/A cg24838063 chr12:130822603 PIWIL1 0.63 8.58 0.47 7.91e-16 Menopause (age at onset); CESC cis rs7714584 1.000 rs10058943 chr5:150226586 A/G cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs9467711 0.516 rs548987 chr6:25869371 C/G cg21479132 chr6:26055353 NA 0.57 6.17 0.35 2.51e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9581857 0.615 rs9581848 chr13:28003997 C/T cg22138327 chr13:27999177 GTF3A 0.66 5.35 0.31 1.9e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs59918340 0.764 rs4961339 chr8:142231504 A/G cg23750338 chr8:142222470 SLC45A4 0.63 9.64 0.51 4.88e-19 Immature fraction of reticulocytes; CESC cis rs11785400 1.000 rs6997670 chr8:143737915 G/A cg10596483 chr8:143751796 JRK 0.43 5.65 0.33 4.1e-8 Schizophrenia; CESC cis rs7635838 0.684 rs346079 chr3:11328139 G/A cg00170343 chr3:11313890 ATG7 0.56 8.18 0.45 1.16e-14 HDL cholesterol; CESC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg23172400 chr8:95962367 TP53INP1 -0.41 -8.29 -0.45 5.85e-15 Type 2 diabetes; CESC cis rs4711336 0.935 rs3818529 chr6:33661106 T/C cg15676125 chr6:33679581 C6orf125 0.36 5.35 0.31 1.89e-7 Height; CESC cis rs11167764 1.000 rs11167764 chr5:141479065 A/C cg08523384 chr5:141488047 NDFIP1 -0.34 -5.09 -0.3 6.87e-7 Crohn's disease; CESC trans rs561341 0.700 rs2074101 chr17:30228656 G/A cg20587970 chr11:113659929 NA -0.61 -7.94 -0.44 5.68e-14 Hip circumference adjusted for BMI; CESC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg02592271 chr2:27665507 KRTCAP3 -0.35 -7.02 -0.4 1.84e-11 Total body bone mineral density; CESC cis rs2898681 0.519 rs7670068 chr4:53733984 T/G cg00791764 chr4:53727839 RASL11B 0.43 5.12 0.3 5.82e-7 Optic nerve measurement (cup area); CESC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg07936489 chr17:37558343 FBXL20 -0.79 -11.47 -0.58 5.27e-25 Glomerular filtration rate (creatinine); CESC cis rs7605827 0.836 rs2052436 chr2:15697518 T/C cg19274914 chr2:15703543 NA 0.3 5.39 0.31 1.59e-7 Educational attainment (years of education); CESC cis rs6582630 0.555 rs11610015 chr12:38508856 A/G cg13010199 chr12:38710504 ALG10B 0.42 5.47 0.32 1.05e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs4835473 0.897 rs6537172 chr4:144631765 C/T cg25736465 chr4:144833511 NA 0.4 6.24 0.36 1.74e-9 Immature fraction of reticulocytes; CESC cis rs2204008 0.658 rs11495742 chr12:38395688 C/A cg26384229 chr12:38710491 ALG10B 0.73 10.43 0.54 1.42e-21 Bladder cancer; CESC cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg17376030 chr22:41985996 PMM1 -0.74 -8.03 -0.44 3.24e-14 Vitiligo; CESC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg11247378 chr22:39784982 NA 0.6 8.68 0.47 4.06e-16 Intelligence (multi-trait analysis); CESC cis rs9640161 0.702 rs11765692 chr7:150026567 C/T cg21361702 chr7:150065534 REPIN1 0.49 5.77 0.33 2.24e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg17376030 chr22:41985996 PMM1 -0.79 -8.55 -0.46 1e-15 Vitiligo; CESC cis rs10791323 0.546 rs55801927 chr11:133713094 A/C cg06766960 chr11:133703094 NA -0.4 -5.67 -0.33 3.7e-8 Childhood ear infection; CESC trans rs10506458 1.000 rs12580997 chr12:63433420 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.32 -17.48 -0.73 4.95e-46 Hemostatic factors and hematological phenotypes; CESC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg20744362 chr22:50050164 C22orf34 0.48 8.45 0.46 1.95e-15 Monocyte count;Monocyte percentage of white cells; CESC cis rs7481584 1.000 rs7481584 chr11:3029089 G/A cg25174290 chr11:3078921 CARS -0.43 -5.41 -0.32 1.43e-7 Calcium levels; CESC cis rs9486719 1.000 rs11152959 chr6:96900272 C/T cg18709589 chr6:96969512 KIAA0776 -0.54 -5.87 -0.34 1.3e-8 Migraine;Coronary artery disease; CESC cis rs9549367 0.789 rs6577031 chr13:113878182 T/C cg00898013 chr13:113819073 PROZ 0.5 7.52 0.42 8.49e-13 Platelet distribution width; CESC cis rs7264396 0.666 rs1536147 chr20:34173046 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.49 6.47 0.37 4.64e-10 Total cholesterol levels; CESC cis rs4423214 0.879 rs4945008 chr11:71221248 A/G cg24826892 chr11:71159390 DHCR7 0.45 5.31 0.31 2.37e-7 Vitamin D levels; CESC cis rs5167 0.504 rs4803779 chr19:45456497 T/C cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.23e-14 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02222103 chr17:5389592 DERL2;MIS12 -0.66 -8.14 -0.45 1.58e-14 Gut microbiome composition (summer); CESC cis rs367615 0.512 rs246104 chr5:108700982 A/C cg17395555 chr5:108820864 NA -0.54 -8.71 -0.47 3.45e-16 Colorectal cancer (SNP x SNP interaction); CESC cis rs6933660 0.760 rs6904364 chr6:151754273 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.44 -5.62 -0.33 4.93e-8 Menarche (age at onset); CESC cis rs4664308 1.000 rs6707458 chr2:160914540 G/T cg03641300 chr2:160917029 PLA2R1 -0.67 -10.07 -0.53 2.06e-20 Idiopathic membranous nephropathy; CESC cis rs713587 0.806 rs6737082 chr2:25138040 A/C cg01884057 chr2:25150051 NA 0.39 7.29 0.41 3.65e-12 Body mass index in non-asthmatics; CESC cis rs2732480 0.500 rs2450986 chr12:48661688 G/A cg04545296 chr12:48745243 ZNF641 0.42 7.06 0.4 1.47e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg06108461 chr20:60628389 TAF4 -0.93 -14.4 -0.66 4.08e-35 Body mass index; CESC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg05872129 chr22:39784769 NA -0.82 -11.17 -0.57 5.22e-24 Intelligence (multi-trait analysis); CESC cis rs11025559 0.796 rs10833317 chr11:20412277 A/T cg19653624 chr11:20408972 PRMT3 -0.47 -5.43 -0.32 1.3e-7 Pursuit maintenance gain; CESC cis rs769267 0.930 rs747050 chr19:19584987 C/G cg03709012 chr19:19516395 GATAD2A 1.01 15.7 0.69 1.02e-39 Tonsillectomy; CESC cis rs9532580 0.620 rs2755210 chr13:41141282 C/G cg21288729 chr13:41239152 FOXO1 0.69 8.04 0.44 2.92e-14 Mean corpuscular hemoglobin; CESC cis rs1950626 0.833 rs72700524 chr14:101417309 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.79 10.67 0.55 2.42e-22 Pelvic organ prolapse (moderate/severe); CESC trans rs208520 0.874 rs208512 chr6:66943869 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.81 -9.39 -0.5 2.82e-18 Exhaled nitric oxide output; CESC cis rs9768139 0.733 rs71545585 chr7:158118672 G/A cg24154853 chr7:158122151 PTPRN2 0.43 6.61 0.38 2.07e-10 Calcium levels; CESC cis rs3105593 1.000 rs62017206 chr15:50955626 A/G cg08437265 chr15:50716283 USP8 0.44 5.66 0.33 3.95e-8 QT interval; CESC cis rs4243830 0.850 rs4434862 chr1:6602241 C/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.99 -10.01 -0.52 3.22e-20 Body mass index; CESC cis rs2087017 0.744 rs9816914 chr3:113816942 T/A cg11311190 chr3:113822454 NA -0.33 -5.91 -0.34 1.08e-8 Personality dimensions; CESC cis rs2953174 0.744 rs2975748 chr2:241518989 A/G cg07929629 chr2:241523174 NA 0.56 6.09 0.35 3.97e-9 Bipolar disorder; CESC cis rs910316 0.967 rs175432 chr14:75615246 C/G cg08847533 chr14:75593920 NEK9 -0.96 -17.56 -0.73 2.63e-46 Height; CESC cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg00033643 chr7:134001901 SLC35B4 0.42 5.47 0.32 1.04e-7 Mean platelet volume; CESC cis rs703842 0.616 rs10877024 chr12:58226709 C/T cg00677455 chr12:58241039 CTDSP2 0.72 9.86 0.52 1.01e-19 Multiple sclerosis; CESC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg14393609 chr7:65229607 NA -0.54 -7.27 -0.41 4.06e-12 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26551688 chr8:103822898 NA -0.45 -6.14 -0.35 2.95e-9 Fibrinogen levels; CESC cis rs2637266 0.714 rs7895605 chr10:78454207 G/A cg18941641 chr10:78392320 NA 0.43 7.82 0.43 1.23e-13 Pulmonary function; CESC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.98 10.55 0.54 5.96e-22 Platelet count; CESC cis rs56161922 0.908 rs113826410 chr1:207849815 C/T cg09557387 chr1:207818395 CR1L 0.68 5.07 0.3 7.54e-7 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg23758822 chr17:41437982 NA 0.94 15.65 0.69 1.46e-39 Menopause (age at onset); CESC cis rs42648 0.869 rs2027965 chr7:89912513 C/T cg23697855 chr7:89950296 NA 0.27 5.19 0.3 4.26e-7 Homocysteine levels; CESC cis rs6977955 0.838 rs917116 chr7:28172739 T/G cg23620719 chr7:28220237 JAZF1 0.53 5.99 0.35 6.74e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.48e-10 Depression; CESC cis rs10465746 0.747 rs34155960 chr1:84447539 T/G cg10977910 chr1:84465055 TTLL7 0.52 7.13 0.4 9.46e-12 Obesity-related traits; CESC cis rs9325144 0.534 rs4882283 chr12:38710249 C/T cg26384229 chr12:38710491 ALG10B 0.64 9.86 0.52 9.6e-20 Morning vs. evening chronotype; CESC cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg20503657 chr10:835505 NA 1.07 9.49 0.5 1.43e-18 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11258043 chr6:73972820 KHDC1 0.58 6.38 0.36 7.8e-10 Gut microbiome composition (summer); CESC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg19622623 chr12:86230825 RASSF9 -0.46 -5.88 -0.34 1.22e-8 Major depressive disorder; CESC cis rs9300255 0.602 rs1106240 chr12:123626982 C/T cg00376283 chr12:123451042 ABCB9 0.62 6.76 0.38 8.89e-11 Neutrophil percentage of white cells; CESC trans rs208520 1.000 rs208520 chr6:66952828 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.78 -8.69 -0.47 3.76e-16 Exhaled nitric oxide output; CESC cis rs9902453 1.000 rs7222308 chr17:28277041 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 8.28 0.45 6.2e-15 Coffee consumption (cups per day); CESC cis rs939574 1.000 rs1109866 chr2:220083279 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.55 -5.26 -0.31 2.94e-7 Platelet distribution width; CESC cis rs10751667 0.857 rs6597952 chr11:991109 C/G cg20946044 chr11:1010712 AP2A2 -0.46 -5.89 -0.34 1.17e-8 Alzheimer's disease (late onset); CESC cis rs7824557 0.583 rs2263511 chr8:11233318 A/C cg21775007 chr8:11205619 TDH -0.53 -8.02 -0.44 3.51e-14 Retinal vascular caliber; CESC cis rs7937682 0.575 rs7124696 chr11:111747297 A/G cg09085632 chr11:111637200 PPP2R1B 0.91 12.08 0.6 4.6e-27 Primary sclerosing cholangitis; CESC trans rs1728785 0.901 rs1645974 chr16:68564774 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg15556689 chr8:8085844 FLJ10661 -0.53 -6.78 -0.38 7.71e-11 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02396143 chr1:29063512 YTHDF2 0.64 7.59 0.42 5.51e-13 Gut microbiome composition (summer); CESC cis rs344364 0.518 rs1657129 chr16:1945826 G/A cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs3740713 1.000 rs73438699 chr11:18462684 C/T cg23797887 chr11:18477753 LDHAL6A -0.53 -5.13 -0.3 5.58e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs644799 0.932 rs480079 chr11:95643777 A/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.6 -8.13 -0.45 1.69e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6496667 0.533 rs2601206 chr15:90962699 C/T cg10434728 chr15:90938212 IQGAP1 0.32 5.65 0.33 4.24e-8 Rheumatoid arthritis; CESC cis rs2952156 0.959 rs1495102 chr17:37832093 T/C cg07936489 chr17:37558343 FBXL20 -0.55 -6.65 -0.38 1.68e-10 Asthma; CESC cis rs4927850 0.723 rs7630825 chr3:195753740 T/C cg00031303 chr3:195681400 NA 0.41 5.1 0.3 6.59e-7 Pancreatic cancer; CESC cis rs6121246 0.909 rs6119720 chr20:30347568 T/G cg13852791 chr20:30311386 BCL2L1 0.81 8.61 0.47 6.48e-16 Mean corpuscular hemoglobin; CESC cis rs9487051 0.676 rs9386788 chr6:109600523 C/T cg01475377 chr6:109611718 NA 0.43 6.84 0.39 5.33e-11 Reticulocyte fraction of red cells; CESC cis rs453301 0.597 rs7001187 chr8:8792782 G/A cg15556689 chr8:8085844 FLJ10661 -0.45 -5.03 -0.3 8.91e-7 Joint mobility (Beighton score); CESC cis rs12765878 1.000 rs11191865 chr10:105672842 G/A cg24587175 chr10:105670608 OBFC1 0.34 5.45 0.32 1.15e-7 Coronary artery disease; CESC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg04944784 chr2:26401820 FAM59B 0.92 9.76 0.51 2.02e-19 Gut microbiome composition (summer); CESC cis rs11098499 0.954 rs11098524 chr4:120390032 A/G cg09307838 chr4:120376055 NA 0.94 12.47 0.61 2.1e-28 Corneal astigmatism; CESC cis rs10242455 0.702 rs73711294 chr7:99088714 G/A cg18809830 chr7:99032528 PTCD1 -0.64 -5.07 -0.3 7.31e-7 Blood metabolite levels; CESC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg04414720 chr1:150670196 GOLPH3L 0.45 5.96 0.34 7.83e-9 Melanoma; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg08914378 chr7:98923334 ARPC1A 0.45 6.03 0.35 5.46e-9 Myopia (pathological); CESC trans rs561341 1.000 rs555629 chr17:30294136 T/C cg27661571 chr11:113659931 NA -0.83 -7.69 -0.43 2.82e-13 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04429285 chr6:28048973 ZNF165 0.61 6.47 0.37 4.76e-10 Gut microbiome composition (summer); CESC trans rs11098499 0.863 rs13140409 chr4:120503460 A/G cg25214090 chr10:38739885 LOC399744 0.66 8.85 0.48 1.28e-16 Corneal astigmatism; CESC cis rs6964587 0.869 rs4729010 chr7:91486751 G/A cg17063962 chr7:91808500 NA -0.53 -7.23 -0.41 5.28e-12 Breast cancer; CESC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg22903471 chr2:27725779 GCKR -0.58 -8.48 -0.46 1.6e-15 Total body bone mineral density; CESC cis rs425277 1.000 rs436045 chr1:2071556 A/G cg24578937 chr1:2090814 PRKCZ -0.54 -9.38 -0.5 3.12e-18 Height; CESC cis rs1401999 1.000 rs7632670 chr3:183713877 A/G cg01324343 chr3:183735012 ABCC5 0.64 13.68 0.64 1.32e-32 Anterior chamber depth; CESC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg15595755 chr5:1867978 NA 0.51 8.38 0.46 3.17e-15 Cardiovascular disease risk factors; CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg04025307 chr7:1156635 C7orf50 0.54 9.09 0.49 2.42e-17 Longevity;Endometriosis; CESC cis rs72781680 1.000 rs72796351 chr2:24158425 T/C cg20701182 chr2:24300061 SF3B14 0.65 5.81 0.34 1.79e-8 Lymphocyte counts; CESC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg04282206 chr17:62833786 PLEKHM1P 0.54 6.41 0.37 6.67e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs13095912 0.785 rs35637544 chr3:185329958 A/G cg11274856 chr3:185301563 NA 0.39 5.73 0.33 2.71e-8 Systolic blood pressure; CESC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg17372223 chr3:52568218 NT5DC2 0.44 6.69 0.38 1.32e-10 Bipolar disorder; CESC cis rs8044868 0.566 rs3812984 chr16:72207797 C/T cg16558253 chr16:72132732 DHX38 -0.4 -6.16 -0.35 2.64e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg14393609 chr7:65229607 NA 0.47 6.29 0.36 1.28e-9 Aortic root size; CESC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg21285383 chr16:89894308 SPIRE2 0.3 5.35 0.31 1.89e-7 Vitiligo; CESC cis rs7605827 0.930 rs13384921 chr2:15602840 C/T cg19274914 chr2:15703543 NA 0.37 6.59 0.38 2.38e-10 Educational attainment (years of education); CESC cis rs61332075 0.500 rs55917008 chr2:239380244 C/A cg18131467 chr2:239335373 ASB1 -0.73 -5.88 -0.34 1.23e-8 Lung function (FEV1/FVC); CESC cis rs2191566 0.664 rs6509138 chr19:44570393 C/A cg20607764 chr19:44506953 ZNF230 -0.44 -5.58 -0.32 5.88e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs2425143 1.000 rs1890470 chr20:34357008 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -8.0 -0.44 3.85e-14 Blood protein levels; CESC cis rs10242455 0.571 rs79694709 chr7:99214711 C/G cg25640893 chr7:99214727 ZNF498 1.15 7.65 0.43 3.65e-13 Blood metabolite levels; CESC cis rs4242434 0.819 rs1059592 chr8:22477778 G/A cg03733263 chr8:22462867 KIAA1967 0.87 14.09 0.65 5.05e-34 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs59918340 0.728 rs4961340 chr8:142232002 G/A cg16341495 chr8:142228727 SLC45A4 -0.44 -5.29 -0.31 2.56e-7 Immature fraction of reticulocytes; CESC cis rs10129255 0.518 rs8010020 chr14:107186255 A/G cg23076370 chr14:107095027 NA -0.65 -9.62 -0.51 5.59e-19 Kawasaki disease; CESC cis rs2276314 0.762 rs3826600 chr18:33609053 A/G cg05985134 chr18:33552581 C18orf21 0.61 7.33 0.41 2.8e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs1215050 0.791 rs165250 chr4:98696259 G/A cg05340658 chr4:99064831 C4orf37 0.49 6.3 0.36 1.26e-9 Waist-to-hip ratio adjusted for body mass index; CESC trans rs62210650 0.881 rs41442149 chr21:20990343 A/C cg17270013 chr15:79236839 CTSH 0.39 6.41 0.37 6.47e-10 Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs17253792 0.822 rs79921041 chr14:56090779 T/C cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs1153858 1.000 rs1145091 chr15:45649996 A/G cg21132104 chr15:45694354 SPATA5L1 0.77 10.48 0.54 9.92e-22 Homoarginine levels; CESC cis rs9929218 0.953 rs16260 chr16:68771034 C/A cg02972257 chr16:68554789 NA 0.55 6.51 0.37 3.77e-10 Colorectal cancer; CESC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs240110 0.539 rs6919745 chr6:101338978 T/C cg09795085 chr6:101329169 ASCC3 0.46 6.0 0.35 6.5e-9 Neuroticism; CESC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg11644478 chr21:40555479 PSMG1 -0.48 -6.22 -0.36 1.89e-9 Cognitive function; CESC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg12516959 chr21:47718080 NA 0.41 5.97 0.34 7.7e-9 Testicular germ cell tumor; CESC cis rs2243480 1.000 rs6460261 chr7:65215580 T/C cg13147721 chr7:65941812 NA 0.88 8.1 0.45 1.96e-14 Diabetic kidney disease; CESC cis rs8002861 0.905 rs12429722 chr13:44412466 T/A cg14210620 chr13:44453864 C13orf31;CCDC122 -0.43 -5.41 -0.32 1.39e-7 Leprosy; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg22695372 chr1:94354654 GCLM 0.38 6.09 0.35 3.9e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8114671 0.562 rs6060064 chr20:33406339 C/G cg07148914 chr20:33460835 GGT7 -0.44 -5.85 -0.34 1.41e-8 Height; CESC cis rs7216064 0.953 rs12601759 chr17:65955284 A/G cg07042672 chr17:66097459 LOC651250 -0.54 -5.8 -0.34 1.84e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4737010 0.501 rs990174 chr8:41632230 A/G cg08923054 chr8:41654455 ANK1 0.47 5.81 0.34 1.74e-8 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03672602 chr19:19754555 GMIP 0.49 6.41 0.37 6.71e-10 Gut microbiota (bacterial taxa); CESC cis rs11252926 0.502 rs7072510 chr10:455596 C/T cg03684893 chr10:554711 DIP2C -0.36 -5.36 -0.31 1.84e-7 Psychosis in Alzheimer's disease; CESC cis rs6942756 0.806 rs68184415 chr7:128988862 C/T cg02491457 chr7:128862824 NA -0.59 -8.37 -0.46 3.34e-15 White matter hyperintensity burden; CESC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg22862634 chr11:62369728 EML3;MTA2 0.6 8.16 0.45 1.37e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg14664628 chr15:75095509 CSK -0.58 -8.21 -0.45 9.96e-15 Breast cancer; CESC cis rs2070488 0.965 rs7372386 chr3:38484175 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 15.98 0.7 1.07e-40 Electrocardiographic conduction measures; CESC cis rs2694528 0.544 rs6449481 chr5:59911179 G/C cg11474532 chr5:59995715 DEPDC1B 0.87 5.78 0.33 2.05e-8 Parkinson's disease; CESC cis rs9309473 0.950 rs10206899 chr2:73900900 T/C cg20560298 chr2:73613845 ALMS1 -0.56 -7.06 -0.4 1.46e-11 Metabolite levels; CESC cis rs854765 0.547 rs2955377 chr17:17932818 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.66 0.47 4.83e-16 Total body bone mineral density; CESC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg27121462 chr16:89883253 FANCA -0.66 -8.66 -0.47 4.8e-16 Vitiligo; CESC cis rs7917772 0.503 rs7093285 chr10:104374815 G/C cg22532475 chr10:104410764 TRIM8 -0.39 -6.43 -0.37 5.85e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg13866156 chr1:1669148 SLC35E2 -0.5 -6.5 -0.37 3.99e-10 Body mass index; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg23171099 chr19:49217468 MAMSTR 0.52 6.43 0.37 5.91e-10 Retinol levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10832476 chr1:28476863 PTAFR 0.45 6.5 0.37 4.01e-10 Fibrinogen levels; CESC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg22105103 chr4:187893119 NA 0.48 6.79 0.38 7.4e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7223966 0.729 rs9902761 chr17:62010627 A/G cg11494091 chr17:61959527 GH2 0.41 5.24 0.31 3.31e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg09491104 chr22:46646882 C22orf40 -0.48 -5.78 -0.33 2.14e-8 LDL cholesterol;Cholesterol, total; CESC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg24549020 chr5:56110836 MAP3K1 0.66 7.45 0.42 1.29e-12 Initial pursuit acceleration; CESC cis rs8070624 0.543 rs4299203 chr17:17878159 T/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.6 7.71 0.43 2.59e-13 Total body bone mineral density; CESC cis rs2354432 0.607 rs68080346 chr1:146708484 T/C cg25205988 chr1:146714368 CHD1L -1.04 -8.53 -0.46 1.14e-15 Mitochondrial DNA levels; CESC cis rs9549367 0.789 rs71446679 chr13:113894821 C/T cg18105134 chr13:113819100 PROZ -0.66 -7.97 -0.44 4.85e-14 Platelet distribution width; CESC cis rs10791097 1.000 rs10791098 chr11:130718711 T/G cg14779329 chr11:130786720 SNX19 0.4 6.24 0.36 1.73e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs61776719 0.738 rs7555461 chr1:38444749 T/C cg04673462 chr1:38461896 NA -0.41 -6.05 -0.35 5.01e-9 Coronary artery disease; CESC trans rs7726839 0.574 rs72707007 chr5:661856 T/C cg25482853 chr8:67687455 SGK3 1.02 10.32 0.54 3.29e-21 Obesity-related traits; CESC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg06221963 chr1:154839813 KCNN3 -0.66 -11.2 -0.57 4.29e-24 Prostate cancer; CESC cis rs4803468 1.000 rs10422783 chr19:41906436 T/C cg08477640 chr19:41863820 B9D2 0.38 5.07 0.3 7.53e-7 Height; CESC cis rs7072216 0.763 rs6584201 chr10:100170209 T/C cg26618903 chr10:100175079 PYROXD2 -0.37 -5.76 -0.33 2.33e-8 Metabolite levels; CESC cis rs644799 0.687 rs11021318 chr11:95522996 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.74 10.86 0.56 5.58e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg23281280 chr6:28129359 ZNF389 0.61 8.26 0.45 6.87e-15 Depression; CESC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg11644478 chr21:40555479 PSMG1 -0.52 -7.14 -0.4 8.98e-12 Menarche (age at onset); CESC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg24549020 chr5:56110836 MAP3K1 -0.65 -7.5 -0.42 9.62e-13 Initial pursuit acceleration; CESC cis rs34779708 0.931 rs4934723 chr10:35381763 A/G cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs9614461 0.702 rs16993867 chr22:45733199 A/G cg22884516 chr22:45809543 SMC1B;RIBC2 0.5 5.08 0.3 7.06e-7 Tonsillectomy; CESC cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 9.04 0.49 3.35e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs796364 0.951 rs11680258 chr2:200996976 T/C cg23649088 chr2:200775458 C2orf69 -0.56 -5.7 -0.33 3.16e-8 Schizophrenia; CESC cis rs13095912 0.785 rs6783023 chr3:185330189 A/G cg11274856 chr3:185301563 NA 0.37 5.51 0.32 8.45e-8 Systolic blood pressure; CESC trans rs78049276 0.512 rs6820938 chr4:148395903 A/G cg13149281 chr14:23389818 RBM23;PRMT5 -0.71 -9.27 -0.49 6.75e-18 Pulse pressure; CESC cis rs1559088 0.749 rs10405757 chr19:33616526 C/A cg27124370 chr19:33622961 WDR88 0.43 5.59 0.32 5.74e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7264396 0.635 rs6060692 chr20:34517925 A/T cg23207816 chr20:34252616 CPNE1;RBM12 -0.55 -6.92 -0.39 3.49e-11 Total cholesterol levels; CESC trans rs6089829 0.962 rs4997812 chr20:61663153 T/G cg23505145 chr19:12996616 KLF1 0.54 6.95 0.39 2.81e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg17724175 chr1:150552817 MCL1 -0.34 -5.46 -0.32 1.12e-7 Tonsillectomy; CESC cis rs6598955 0.670 rs6676619 chr1:26539035 T/G cg00852783 chr1:26633632 UBXN11 0.4 5.81 0.34 1.79e-8 Obesity-related traits; CESC cis rs10823500 0.748 rs7072230 chr10:71978144 A/G cg02100629 chr10:71892760 AIFM2 -0.32 -5.13 -0.3 5.6e-7 Blood protein levels; CESC cis rs6088590 1.000 rs6088590 chr20:33313566 T/C cg08999081 chr20:33150536 PIGU 0.57 8.82 0.48 1.56e-16 Coronary artery disease; CESC cis rs6681460 0.932 rs2044399 chr1:67054080 T/C cg02459107 chr1:67143332 SGIP1 0.36 5.08 0.3 7.08e-7 Presence of antiphospholipid antibodies; CESC cis rs9902453 0.817 rs2321333 chr17:28140857 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.77 10.34 0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs2658782 0.547 rs4344448 chr11:93047047 T/C cg15737290 chr11:93063684 CCDC67 0.52 7.23 0.41 5.13e-12 Pulmonary function decline; CESC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.09 0.3 6.66e-7 Height; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg03742932 chr7:90338067 CDK14 -0.48 -6.69 -0.38 1.33e-10 Thyroid stimulating hormone; CESC cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg04450456 chr4:17643702 FAM184B 0.37 5.23 0.31 3.4e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20383078 chr12:93965728 SOCS2 0.58 6.97 0.39 2.47e-11 Gut microbiome composition (summer); CESC cis rs7103648 1.000 rs10838709 chr11:47447346 C/T cg03711944 chr11:47377212 SPI1 -0.32 -5.05 -0.3 8.21e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs10751667 0.666 rs4074234 chr11:977715 C/G cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.48e-7 Alzheimer's disease (late onset); CESC cis rs4713675 0.584 rs7759668 chr6:33670406 C/T cg14003231 chr6:33640908 ITPR3 -0.36 -6.21 -0.36 2e-9 Plateletcrit; CESC cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.82 -12.1 -0.6 3.83e-27 Systemic lupus erythematosus; CESC cis rs4660306 1.000 rs4660306 chr1:45978675 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.59 7.44 0.42 1.4e-12 Homocysteine levels; CESC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg00339695 chr16:24857497 SLC5A11 0.54 6.72 0.38 1.12e-10 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.29 0.45 5.64e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg21770322 chr7:97807741 LMTK2 0.58 8.8 0.48 1.82e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg01448562 chr3:133502909 NA -0.44 -6.03 -0.35 5.42e-9 Iron status biomarkers; CESC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.74 -9.68 -0.51 3.62e-19 Mean platelet volume; CESC cis rs6076065 0.748 rs2295239 chr20:23387550 C/T cg11657817 chr20:23433608 CST11 0.4 6.1 0.35 3.7e-9 Facial morphology (factor 15, philtrum width); CESC cis rs8060686 0.545 rs12600062 chr16:68287544 C/A cg26727032 chr16:67993705 SLC12A4 -0.51 -5.35 -0.31 1.94e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs6500395 1.000 rs12933948 chr16:48705825 C/G cg04672837 chr16:48644449 N4BP1 -0.49 -6.06 -0.35 4.66e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19468962 chr19:33622911 WDR88 -0.43 -6.17 -0.35 2.54e-9 Gut microbiota (bacterial taxa); CESC cis rs3806843 0.741 rs4912597 chr5:140106857 C/G cg26395211 chr5:140044315 WDR55 0.47 5.95 0.34 8.5e-9 Depressive symptoms (multi-trait analysis); CESC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7945705 0.837 rs10769981 chr11:9024460 T/C cg12365402 chr11:9010492 NRIP3 0.43 7.06 0.4 1.42e-11 Hemoglobin concentration; CESC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.46 6.05 0.35 5.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.39 -6.06 -0.35 4.63e-9 Personality dimensions; CESC cis rs4242434 0.757 rs2280104 chr8:22525980 C/T cg03733263 chr8:22462867 KIAA1967 0.8 11.65 0.58 1.33e-25 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg13206674 chr6:150067644 NUP43 0.39 5.53 0.32 7.66e-8 Lung cancer; CESC cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg05340658 chr4:99064831 C4orf37 0.78 11.71 0.58 8.33e-26 Colonoscopy-negative controls vs population controls; CESC cis rs17125944 0.505 rs77949716 chr14:53204234 G/A cg13660082 chr14:53194042 PSMC6 -0.67 -5.83 -0.34 1.58e-8 Alzheimer's disease (late onset); CESC cis rs9948 0.786 rs62156231 chr2:97425603 G/A cg01990225 chr2:97406019 LMAN2L -0.93 -7.49 -0.42 1.04e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg25036284 chr2:26402008 FAM59B -0.59 -6.71 -0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs4132509 0.793 rs4478795 chr1:243844576 C/T cg21452805 chr1:244014465 NA 0.57 6.4 0.37 6.85e-10 RR interval (heart rate); CESC cis rs9858542 0.953 rs7646366 chr3:49470668 G/A cg07274523 chr3:49395745 GPX1 0.67 8.24 0.45 8.23e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs962856 0.719 rs12713597 chr2:67621067 T/C cg09028215 chr2:67624308 ETAA1 -0.44 -5.64 -0.33 4.26e-8 Pancreatic cancer; CESC cis rs710216 0.536 rs710221 chr1:43414200 G/A cg07803811 chr1:43423981 SLC2A1 0.6 7.98 0.44 4.31e-14 Red cell distribution width; CESC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg26335602 chr6:28129616 ZNF389 -0.49 -6.39 -0.37 7.58e-10 Depression; CESC cis rs4074961 0.527 rs6704190 chr1:38010751 C/T cg13401533 chr1:37979913 MEAF6 0.44 5.48 0.32 9.98e-8 Axial length; CESC cis rs3091242 0.933 rs28633797 chr1:25741629 C/A cg02931644 chr1:25747376 RHCE 0.39 6.4 0.37 7e-10 Erythrocyte sedimentation rate; CESC cis rs6502050 0.871 rs8072702 chr17:80074280 C/T cg11859384 chr17:80120422 CCDC57 0.4 5.52 0.32 8.22e-8 Life satisfaction; CESC cis rs12142240 0.698 rs68012736 chr1:46839510 A/G cg10495392 chr1:46806563 NSUN4 0.58 6.26 0.36 1.54e-9 Menopause (age at onset); CESC cis rs1499614 1.000 rs2141924 chr7:66186246 C/T cg13147721 chr7:65941812 NA -0.94 -8.9 -0.48 9.08e-17 Gout; CESC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 12.17 0.6 2.39e-27 Alzheimer's disease; CESC cis rs7429990 0.965 rs1137524 chr3:47956424 C/T cg11946769 chr3:48343235 NME6 0.42 5.07 0.3 7.49e-7 Educational attainment (years of education); CESC cis rs8062405 0.755 rs1074631 chr16:28554108 A/G cg07382826 chr16:28625726 SULT1A1 -0.4 -6.51 -0.37 3.65e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg03188948 chr7:1209495 NA 0.73 7.81 0.43 1.31e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1371867 0.846 rs1660348 chr8:101315248 A/G cg11906718 chr8:101322791 RNF19A 0.46 5.92 0.34 1.02e-8 Atrioventricular conduction; CESC trans rs6981523 0.553 rs2409730 chr8:11060638 C/A cg06636001 chr8:8085503 FLJ10661 -0.53 -6.25 -0.36 1.67e-9 Neuroticism; CESC cis rs10504229 0.871 rs56048296 chr8:58163781 C/T cg24829409 chr8:58192753 C8orf71 -0.62 -8.78 -0.47 2.03e-16 Developmental language disorder (linguistic errors); CESC cis rs854765 0.724 rs2955371 chr17:17967397 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.5 -6.89 -0.39 4e-11 Total body bone mineral density; CESC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg06108461 chr20:60628389 TAF4 -0.95 -15.02 -0.68 2.56e-37 Body mass index; CESC cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg16278512 chr7:12443529 VWDE -0.5 -5.08 -0.3 7.3e-7 Coronary artery disease; CESC cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.78 -10.94 -0.56 3.2e-23 Chronic sinus infection; CESC trans rs11098499 0.866 rs10518329 chr4:120401835 A/G cg25214090 chr10:38739885 LOC399744 0.61 8.92 0.48 8.03e-17 Corneal astigmatism; CESC cis rs4242434 0.927 rs13271626 chr8:22467760 C/G cg03733263 chr8:22462867 KIAA1967 0.92 13.69 0.64 1.26e-32 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs2742234 0.541 rs61268333 chr10:43721370 G/A cg15436174 chr10:43711423 RASGEF1A 0.47 5.58 0.32 5.81e-8 Hirschsprung disease; CESC cis rs8005677 1.000 rs10148215 chr14:23382345 C/T cg25600027 chr14:23388339 RBM23 -0.45 -5.49 -0.32 9.62e-8 Cognitive ability (multi-trait analysis); CESC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg18758796 chr5:131593413 PDLIM4 0.47 6.82 0.39 6.01e-11 Breast cancer; CESC cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg02551604 chr5:131831745 NA -0.37 -5.27 -0.31 2.81e-7 Asthma (sex interaction); CESC cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg05283184 chr6:79620031 NA -0.43 -6.56 -0.37 2.83e-10 Intelligence (multi-trait analysis); CESC cis rs9611565 0.614 rs4822053 chr22:42212936 C/A cg06481639 chr22:41940642 POLR3H -0.46 -5.37 -0.31 1.73e-7 Vitiligo; CESC trans rs7824557 0.527 rs2572449 chr8:11239137 A/G cg06636001 chr8:8085503 FLJ10661 0.49 6.46 0.37 4.98e-10 Retinal vascular caliber; CESC cis rs11190604 0.673 rs10883498 chr10:102228709 T/A cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs9443645 0.901 rs9361480 chr6:79724429 C/T cg05283184 chr6:79620031 NA -0.36 -5.46 -0.32 1.11e-7 Intelligence (multi-trait analysis); CESC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg27266027 chr21:40555129 PSMG1 0.47 5.63 0.33 4.62e-8 Cognitive function; CESC cis rs12477438 0.520 rs6741772 chr2:99738961 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.4 0.69 1.17e-38 Chronic sinus infection; CESC cis rs3815700 0.614 rs259255 chr19:33151765 T/C cg25945090 chr19:33463020 C19orf40;CCDC123 0.75 5.2 0.3 3.95e-7 Eosinophilic esophagitis; CESC cis rs17253792 0.822 rs17832371 chr14:56162302 C/A cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs7833790 0.929 rs28464834 chr8:82797356 A/T cg02079420 chr8:82753780 SNX16 -0.55 -7.45 -0.42 1.34e-12 Diastolic blood pressure; CESC cis rs798766 0.903 rs798726 chr4:1685211 C/T cg05874882 chr4:1763078 NA 0.54 7.18 0.4 6.89e-12 Bladder cancer;Urinary bladder cancer; CESC cis rs2276314 0.857 rs28431958 chr18:33578401 T/G cg05985134 chr18:33552581 C18orf21 0.61 7.03 0.4 1.72e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg18302933 chr2:88491318 NA -0.32 -5.07 -0.3 7.32e-7 Response to metformin (IC50); CESC cis rs7917772 0.565 rs61869210 chr10:104437175 A/C cg22532475 chr10:104410764 TRIM8 -0.38 -5.52 -0.32 7.94e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg12193833 chr17:30244370 NA -0.75 -6.57 -0.37 2.6e-10 Hip circumference adjusted for BMI; CESC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg27170947 chr2:26402098 FAM59B -0.83 -9.92 -0.52 6.4e-20 Gut microbiome composition (summer); CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg02493798 chr17:6899577 ALOX12 0.42 7.35 0.41 2.47e-12 Tonsillectomy; CESC cis rs34779708 0.750 rs35032841 chr10:35312687 G/A cg04310649 chr10:35416472 CREM -0.5 -5.95 -0.34 8.64e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs6696846 0.765 rs11240360 chr1:205083865 T/C cg00857998 chr1:205179979 DSTYK 0.54 7.13 0.4 9.57e-12 Red blood cell count; CESC cis rs7089973 0.604 rs17095662 chr10:116596071 A/C cg23260525 chr10:116636907 FAM160B1 0.41 7.39 0.41 1.87e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.56 0.42 6.58e-13 Tonsillectomy; CESC cis rs10870270 0.956 rs11146325 chr10:133767529 A/G cg08754478 chr10:133766260 PPP2R2D -0.59 -7.62 -0.42 4.57e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs11677416 1.000 rs4848303 chr2:113552698 A/G cg27083787 chr2:113543245 IL1A 0.62 7.72 0.43 2.32e-13 Response to antipsychotic treatment in schizophrenia (working memory); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18001435 chr13:111291955 CARKD -0.55 -6.4 -0.37 7.1e-10 Gut microbiome composition (summer); CESC cis rs4148883 0.504 rs28720150 chr4:100132790 T/G cg12011299 chr4:100065546 ADH4 -0.51 -7.19 -0.4 6.6e-12 Alcohol dependence; CESC cis rs11758351 0.660 rs11753131 chr6:26219384 G/A cg23601095 chr6:26197514 HIST1H3D 0.91 9.96 0.52 4.64e-20 Gout;Renal underexcretion gout; CESC cis rs9910055 0.530 rs2269907 chr17:42294215 G/A cg13607699 chr17:42295918 UBTF 0.81 12.59 0.61 8.66e-29 Total body bone mineral density; CESC cis rs11098499 0.874 rs12502503 chr4:120116255 C/T cg09307838 chr4:120376055 NA 0.75 9.35 0.5 3.76e-18 Corneal astigmatism; CESC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg10351095 chr21:47802916 PCNT -0.5 -7.01 -0.4 1.99e-11 Testicular germ cell tumor; CESC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg02951883 chr7:2050386 MAD1L1 -0.44 -5.69 -0.33 3.4e-8 Bipolar disorder and schizophrenia; CESC cis rs208520 1.000 rs208521 chr6:66953625 C/T cg07460842 chr6:66804631 NA -0.9 -10.34 -0.54 2.79e-21 Exhaled nitric oxide output; CESC cis rs74181299 0.806 rs2723063 chr2:65280185 A/G cg05010058 chr2:65284262 CEP68 0.3 5.16 0.3 4.93e-7 Pulse pressure; CESC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg26335602 chr6:28129616 ZNF389 0.52 6.84 0.39 5.58e-11 Parkinson's disease; CESC cis rs6028335 0.674 rs57993460 chr20:37662068 C/A cg16355469 chr20:37678765 NA 0.54 5.27 0.31 2.89e-7 Alcohol and nicotine co-dependence; CESC cis rs4654899 1.000 rs6681064 chr1:21339644 A/G cg05370193 chr1:21551575 ECE1 0.38 5.75 0.33 2.48e-8 Superior frontal gyrus grey matter volume; CESC cis rs17854409 0.764 rs8116995 chr20:61475824 A/G cg05147244 chr20:61493195 TCFL5 0.92 6.73 0.38 1.07e-10 Obesity-related traits; CESC cis rs1395 0.778 rs6709602 chr2:27405497 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 5.75 0.33 2.45e-8 Blood metabolite levels; CESC cis rs8114671 0.836 rs17404569 chr20:33674077 A/C cg24642439 chr20:33292090 TP53INP2 -0.47 -5.7 -0.33 3.19e-8 Height; CESC cis rs763121 0.962 rs138703 chr22:39132748 C/T cg06544989 chr22:39130855 UNC84B 0.46 8.56 0.47 9.32e-16 Menopause (age at onset); CESC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg07308232 chr7:1071921 C7orf50 -0.63 -9.11 -0.49 2.15e-17 Longevity;Endometriosis; CESC cis rs17384381 1.000 rs35193119 chr1:85859265 T/C cg16011679 chr1:85725395 C1orf52 0.8 8.15 0.45 1.47e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs27434 0.529 rs42443 chr5:96156224 G/A cg16492584 chr5:96139282 ERAP1 -0.36 -5.09 -0.3 6.81e-7 Ankylosing spondylitis; CESC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg18402987 chr7:1209562 NA 0.75 7.39 0.41 1.9e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg17724175 chr1:150552817 MCL1 0.39 5.93 0.34 9.43e-9 Melanoma; CESC cis rs5753618 0.583 rs7285619 chr22:31842554 C/T cg02404636 chr22:31891804 SFI1 0.39 5.25 0.31 3.1e-7 Colorectal cancer; CESC cis rs4253772 0.550 rs738444 chr22:46721088 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.78 9.23 0.49 8.88e-18 LDL cholesterol;Cholesterol, total; CESC cis rs7918232 0.825 rs4749233 chr10:27467967 G/A cg14442939 chr10:27389572 ANKRD26 0.7 6.99 0.39 2.29e-11 Breast cancer; CESC trans rs11098499 0.863 rs11947234 chr4:120474859 A/G cg25214090 chr10:38739885 LOC399744 0.66 8.96 0.48 5.92e-17 Corneal astigmatism; CESC cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg11764359 chr7:65958608 NA 0.81 9.55 0.51 9.32e-19 Aortic root size; CESC cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.91e-28 Colonoscopy-negative controls vs population controls; CESC cis rs11153306 1.000 rs11153306 chr6:111950649 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.35 -5.21 -0.3 3.82e-7 Tonsillectomy; CESC cis rs611744 0.631 rs627392 chr8:109254677 C/T cg21045802 chr8:109455806 TTC35 0.49 6.06 0.35 4.71e-9 Dupuytren's disease; CESC cis rs72945132 0.882 rs72949081 chr11:70219070 A/G cg00319359 chr11:70116639 PPFIA1 0.78 7.12 0.4 9.86e-12 Coronary artery disease; CESC cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg15605315 chr1:45957053 TESK2 0.49 6.42 0.37 6.28e-10 High light scatter reticulocyte count; CESC cis rs8180040 1.000 rs295428 chr3:47359262 G/T cg27129171 chr3:47204927 SETD2 0.66 10.1 0.53 1.7e-20 Colorectal cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23857200 chr19:39882127 MED29;PAF1 -0.42 -6.11 -0.35 3.47e-9 Gambling; CESC trans rs17039065 0.920 rs7674961 chr4:109440528 G/A cg27151770 chr16:49620536 ZNF423 -0.51 -6.21 -0.36 2.09e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.41 -0.37 6.76e-10 Life satisfaction; CESC cis rs6598955 0.585 rs12138111 chr1:26590432 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC cis rs8114671 0.967 rs1415773 chr20:33765585 G/A cg24642439 chr20:33292090 TP53INP2 0.44 5.26 0.31 2.95e-7 Height; CESC cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg15506890 chr2:3487001 NA -0.5 -6.45 -0.37 5.28e-10 Neurofibrillary tangles; CESC cis rs4481887 0.927 rs4244173 chr1:248466899 G/C cg00666640 chr1:248458726 OR2T12 0.4 6.58 0.37 2.52e-10 Common traits (Other); CESC cis rs6142102 0.502 rs58393429 chr20:32545802 C/G cg08999081 chr20:33150536 PIGU 0.35 5.32 0.31 2.18e-7 Skin pigmentation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18538297 chr19:58892579 ZNF837 0.58 7.11 0.4 1.07e-11 Gut microbiome composition (summer); CESC cis rs2180341 0.596 rs12215298 chr6:127676833 C/T cg24812749 chr6:127587940 RNF146 0.73 9.35 0.5 3.75e-18 Breast cancer; CESC trans rs57221529 0.709 rs72706612 chr5:561198 C/T cg25482853 chr8:67687455 SGK3 1.12 11.92 0.59 1.58e-26 Lung disease severity in cystic fibrosis; CESC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.05 17.19 0.73 5.42e-45 Height; CESC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.61 -7.6 -0.42 5.02e-13 Height; CESC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.65 0.38 1.71e-10 Prudent dietary pattern; CESC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg27572855 chr1:25598939 RHD 0.45 7.59 0.42 5.61e-13 Erythrocyte sedimentation rate; CESC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg24549020 chr5:56110836 MAP3K1 0.65 7.54 0.42 7.42e-13 Initial pursuit acceleration; CESC cis rs2011503 1.000 rs2965181 chr19:19512317 C/T cg11584989 chr19:19387371 SF4 0.63 7.42 0.41 1.63e-12 Bipolar disorder; CESC trans rs6991952 0.845 rs7822766 chr8:25742279 A/T cg06665941 chr21:34602869 IFNAR2 -0.48 -6.09 -0.35 3.97e-9 Inguinal hernia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12121965 chr21:46293563 PTTG1IP -0.5 -6.49 -0.37 4.11e-10 Ulcerative colitis; CESC cis rs7621025 0.691 rs4678438 chr3:136344920 A/C cg15507776 chr3:136538369 TMEM22 0.41 5.08 0.3 7.18e-7 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12197656 chr2:85108351 C2orf89 0.54 6.43 0.37 6.08e-10 Gut microbiome composition (summer); CESC cis rs4836694 0.517 rs1017112 chr9:132936804 A/G cg13414629 chr9:132935646 FREQ 0.44 5.56 0.32 6.66e-8 Alzheimer's disease (cognitive decline); CESC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg12373951 chr3:133503437 NA -0.52 -7.66 -0.43 3.4e-13 Iron status biomarkers; CESC cis rs765787 0.556 rs2413778 chr15:45539397 C/A cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs60154123 0.505 rs76101197 chr1:210044089 T/C cg22029157 chr1:209979665 IRF6 0.73 7.51 0.42 8.78e-13 Coronary artery disease; CESC cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg03467027 chr4:99064603 C4orf37 0.45 5.67 0.33 3.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs28374715 0.681 rs59000092 chr15:41626148 A/G cg02330683 chr15:41787940 ITPKA 0.47 6.28 0.36 1.35e-9 Ulcerative colitis; CESC cis rs2832191 0.671 rs68101501 chr21:30513229 G/T cg08807101 chr21:30365312 RNF160 -0.54 -6.29 -0.36 1.3e-9 Dental caries; CESC cis rs11051970 0.559 rs11051986 chr12:32555273 A/G cg24626660 chr12:32551988 NA 0.36 5.27 0.31 2.77e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs765787 0.530 rs1648289 chr15:45516494 A/G cg24006582 chr15:45444508 DUOX1 -0.53 -6.64 -0.38 1.75e-10 Uric acid levels; CESC trans rs9929218 0.529 rs35854485 chr16:68730855 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.88 14.37 0.66 5.19e-35 Colorectal cancer; CESC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg16680214 chr1:154839983 KCNN3 -0.44 -6.76 -0.38 8.73e-11 Prostate cancer; CESC cis rs2304069 0.954 rs1962603 chr5:149393006 G/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.91 11.66 0.58 1.21e-25 HIV-1 control; CESC cis rs6088580 0.634 rs6059887 chr20:33101102 C/G cg08999081 chr20:33150536 PIGU 0.65 11.26 0.57 2.65e-24 Glomerular filtration rate (creatinine); CESC cis rs34779708 0.931 rs17583009 chr10:35320915 T/C cg03585969 chr10:35415529 CREM 0.75 9.82 0.52 1.31e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs6665290 0.594 rs17592479 chr1:227173892 T/A cg10327440 chr1:227177885 CDC42BPA -1.12 -24.29 -0.83 2.31e-69 Myeloid white cell count; CESC cis rs7829975 0.514 rs2979151 chr8:8258019 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -5.5 -0.32 8.89e-8 Mood instability; CESC cis rs1707322 1.000 rs12097761 chr1:46291162 T/C cg05343316 chr1:45956843 TESK2 0.49 5.88 0.34 1.22e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg04166393 chr7:2884313 GNA12 0.6 8.23 0.45 8.69e-15 Height; CESC cis rs7633857 0.532 rs9858335 chr3:160760146 A/G cg03342759 chr3:160939853 NMD3 -0.44 -6.05 -0.35 4.89e-9 Educational attainment (years of education); CESC cis rs79839061 0.666 rs62297063 chr4:869708 G/A cg07828340 chr4:882639 GAK 1.07 8.26 0.45 6.86e-15 Intelligence (multi-trait analysis); CESC trans rs208520 0.690 rs207082 chr6:66773796 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.97 -12.37 -0.61 4.83e-28 Exhaled nitric oxide output; CESC cis rs7267979 0.714 rs1555329 chr20:25231858 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.71 11.38 0.57 1.04e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs910316 0.737 rs175055 chr14:75488946 T/G cg11812906 chr14:75593930 NEK9 -0.81 -13.25 -0.63 4.31e-31 Height; CESC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg20243544 chr17:37824526 PNMT -0.45 -5.64 -0.33 4.3e-8 Glomerular filtration rate (creatinine); CESC cis rs7044106 0.512 rs7873848 chr9:123354222 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.67 9.7 0.51 3.2e-19 Hip circumference adjusted for BMI; CESC trans rs7246760 1.000 rs67507476 chr19:9852948 G/A cg02900749 chr2:68251473 NA -0.84 -7.32 -0.41 2.99e-12 Pursuit maintenance gain; CESC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg05457628 chr5:178986728 RUFY1 -0.51 -7.46 -0.42 1.26e-12 Lung cancer; CESC cis rs6088580 0.634 rs6141471 chr20:33006730 A/G cg08999081 chr20:33150536 PIGU -0.65 -11.34 -0.57 1.5e-24 Glomerular filtration rate (creatinine); CESC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg18016565 chr1:150552671 MCL1 0.33 5.09 0.3 6.9e-7 Tonsillectomy; CESC trans rs61931739 0.500 rs34061369 chr12:34519283 C/T cg13010199 chr12:38710504 ALG10B 0.5 6.42 0.37 6.3e-10 Morning vs. evening chronotype; CESC trans rs208520 0.674 rs207103 chr6:66795568 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.83 -0.62 1.2e-29 Exhaled nitric oxide output; CESC cis rs8067354 0.872 rs2645483 chr17:57848184 T/G cg13753209 chr17:57696993 CLTC 0.5 6.75 0.38 9.33e-11 Hemoglobin concentration; CESC cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg03060546 chr3:49711283 APEH 0.49 5.89 0.34 1.16e-8 Parkinson's disease; CESC cis rs1580019 0.844 rs1584615 chr7:32503258 G/C cg06627557 chr7:32535165 LSM5;AVL9 0.89 12.64 0.61 5.67e-29 Cognitive ability; CESC cis rs2749592 0.550 rs12255038 chr10:37869332 T/C cg25427524 chr10:38739819 LOC399744 0.57 7.93 0.44 5.98e-14 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6429082 0.714 rs704719 chr1:235667170 G/A cg26050004 chr1:235667680 B3GALNT2 0.68 8.26 0.45 7.1e-15 Adiposity; CESC cis rs3806843 0.966 rs2337516 chr5:140140853 A/G cg16179182 chr5:140090404 VTRNA1-1 0.43 5.64 0.33 4.31e-8 Depressive symptoms (multi-trait analysis); CESC cis rs11630290 0.592 rs1912048 chr15:64155974 G/A cg12036633 chr15:63758958 NA 0.45 5.46 0.32 1.12e-7 Iris characteristics; CESC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg11663144 chr21:46675770 NA -0.48 -7.28 -0.41 3.76e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6987853 0.787 rs10958722 chr8:42425487 T/C cg09913449 chr8:42400586 C8orf40 0.45 7.62 0.42 4.61e-13 Mean corpuscular hemoglobin concentration; CESC cis rs3768617 0.610 rs10911228 chr1:183049792 T/C ch.1.3577855R chr1:183094577 LAMC1 0.66 9.11 0.49 2.07e-17 Fuchs's corneal dystrophy; CESC cis rs4595586 0.525 rs17464772 chr12:39247777 G/A cg13010199 chr12:38710504 ALG10B 0.56 7.57 0.42 6.21e-13 Morning vs. evening chronotype; CESC cis rs7555523 0.887 rs2790053 chr1:165737704 C/G cg24409356 chr1:165738333 TMCO1 0.98 8.91 0.48 8.52e-17 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs1153858 1.000 rs12441971 chr15:45671957 A/T cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs6582630 0.519 rs1851130 chr12:38507819 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.9 0.34 1.13e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9911578 1.000 rs999431 chr17:56854441 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.24 0.31 3.22e-7 Intelligence (multi-trait analysis); CESC cis rs1775715 0.678 rs2105360 chr10:32210198 C/T cg18675610 chr10:32216311 ARHGAP12 0.35 5.43 0.32 1.27e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs67478160 0.619 rs11623546 chr14:104269098 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.09 -0.4 1.2e-11 Schizophrenia; CESC cis rs16854884 0.683 rs6766544 chr3:143736659 G/T cg06585982 chr3:143692056 C3orf58 0.5 6.7 0.38 1.26e-10 Economic and political preferences (feminism/equality); CESC cis rs748404 0.697 rs498227 chr15:43573052 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.98 0.44 4.54e-14 Lung cancer; CESC cis rs9467711 0.606 rs9366653 chr6:26354247 G/A cg12826209 chr6:26865740 GUSBL1 0.62 5.31 0.31 2.36e-7 Autism spectrum disorder or schizophrenia; CESC cis rs300703 0.576 rs3791216 chr2:237142 C/A cg21211680 chr2:198530 NA 0.92 7.6 0.42 5.03e-13 Blood protein levels; CESC cis rs11247915 0.561 rs12750420 chr1:26608649 G/A cg04990556 chr1:26633338 UBXN11 -0.62 -6.88 -0.39 4.24e-11 Obesity-related traits; CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg14159672 chr1:205819179 PM20D1 0.95 16.72 0.72 2.48e-43 Menarche (age at onset); CESC trans rs9929218 0.559 rs11642362 chr16:68811307 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.86 13.68 0.64 1.32e-32 Colorectal cancer; CESC trans rs561341 1.000 rs55978022 chr17:30275937 T/C cg20587970 chr11:113659929 NA -1.49 -19.52 -0.77 3.46e-53 Hip circumference adjusted for BMI; CESC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg17949981 chr6:28129498 ZNF389 0.44 5.53 0.32 7.84e-8 Depression; CESC cis rs7267979 1.000 rs2482930 chr20:25334115 G/C cg08601574 chr20:25228251 PYGB -0.36 -5.05 -0.3 8.07e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs919433 0.963 rs12617117 chr2:198155170 T/A cg03934865 chr2:198174659 NA -0.4 -5.32 -0.31 2.17e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg00033643 chr7:134001901 SLC35B4 0.42 5.47 0.32 1.04e-7 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03553080 chr16:88697695 ZC3H18 0.47 6.71 0.38 1.18e-10 Fibrinogen levels; CESC trans rs7246760 1.000 rs56357664 chr19:9903399 C/T cg02900749 chr2:68251473 NA -0.78 -6.84 -0.39 5.48e-11 Pursuit maintenance gain; CESC cis rs12410462 0.892 rs75757169 chr1:227629855 A/G cg23173402 chr1:227635558 NA 0.59 6.06 0.35 4.66e-9 Major depressive disorder; CESC cis rs11122272 0.735 rs2355873 chr1:231477442 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.24 0.36 1.74e-9 Hemoglobin concentration; CESC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.59 7.73 0.43 2.2e-13 Menopause (age at onset); CESC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.97 9.35 0.5 3.75e-18 Platelet count; CESC trans rs4332037 0.901 rs11767040 chr7:1945468 C/T cg11693508 chr17:37793320 STARD3 0.7 6.63 0.38 1.89e-10 Bipolar disorder; CESC cis rs2921036 0.529 rs2979192 chr8:8338147 C/T cg15556689 chr8:8085844 FLJ10661 0.53 6.61 0.38 2.12e-10 Neuroticism; CESC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg11941060 chr3:133502564 NA 0.44 6.09 0.35 3.91e-9 Iron status biomarkers; CESC cis rs16854884 0.837 rs6804060 chr3:143804040 C/T cg06585982 chr3:143692056 C3orf58 0.42 5.12 0.3 5.99e-7 Economic and political preferences (feminism/equality); CESC cis rs738322 1.000 rs4382 chr22:38570842 T/C cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC trans rs1493916 0.905 rs34910379 chr18:31400047 A/G cg27147174 chr7:100797783 AP1S1 -0.55 -7.47 -0.42 1.19e-12 Life satisfaction; CESC cis rs17253792 0.822 rs112739186 chr14:56065167 A/T cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.62 0.33 4.81e-8 Putamen volume; CESC cis rs12971120 0.838 rs2241510 chr18:72180739 G/A cg26446133 chr18:72167187 CNDP2 -0.73 -8.98 -0.48 5.09e-17 Refractive error; CESC cis rs4919087 1.000 rs4919087 chr10:99072507 C/T cg25902810 chr10:99078978 FRAT1 -0.7 -10.41 -0.54 1.66e-21 Monocyte count; CESC cis rs2204008 0.743 rs2127952 chr12:37995364 G/T cg13010199 chr12:38710504 ALG10B 0.46 5.68 0.33 3.46e-8 Bladder cancer; CESC cis rs3858526 0.834 rs7129481 chr11:5991114 G/T cg05234568 chr11:5960015 NA -0.45 -5.17 -0.3 4.7e-7 DNA methylation (variation); CESC cis rs9309473 0.687 rs11693531 chr2:73608614 C/G cg20560298 chr2:73613845 ALMS1 -0.49 -6.75 -0.38 9.22e-11 Metabolite levels; CESC cis rs736408 0.924 rs2535629 chr3:52833219 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.42 5.26 0.31 2.96e-7 Bipolar disorder; CESC cis rs796364 0.806 rs74724807 chr2:201005109 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -6.48 -0.37 4.47e-10 Schizophrenia; CESC cis rs250677 0.522 rs10040798 chr5:148367324 A/G cg18129178 chr5:148520854 ABLIM3 0.46 5.12 0.3 5.9e-7 Breast cancer; CESC cis rs7847628 0.551 rs10818476 chr9:123572038 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.94 17.29 0.73 2.29e-45 Birth weight; CESC cis rs8064299 0.655 rs12797 chr17:72766993 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.54 7.34 0.41 2.54e-12 Monocyte count; CESC cis rs13034020 0.522 rs62150970 chr2:61244410 C/G cg18625361 chr2:61244694 PEX13;PUS10 0.64 6.18 0.35 2.39e-9 Hodgkin's lymphoma; CESC trans rs2216164 0.966 rs7956817 chr12:68573934 T/A cg27495728 chr7:99067116 NA -0.34 -6.02 -0.35 5.75e-9 Alopecia areata; CESC cis rs4718428 0.672 rs4718412 chr7:66286867 C/T cg12165864 chr7:66369176 NA 0.58 6.15 0.35 2.92e-9 Corneal structure; CESC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg17178900 chr1:205818956 PM20D1 0.63 10.13 0.53 1.32e-20 Monocyte percentage of white cells; CESC cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg02487422 chr3:49467188 NICN1 0.4 5.11 0.3 6.09e-7 Parkinson's disease; CESC cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.78 7.01 0.4 1.93e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs796364 0.951 rs6722092 chr2:201059371 G/T cg23649088 chr2:200775458 C2orf69 0.5 5.26 0.31 2.98e-7 Schizophrenia; CESC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg11494091 chr17:61959527 GH2 -0.72 -12.38 -0.61 4.26e-28 Prudent dietary pattern; CESC cis rs6831256 0.550 rs9993109 chr4:3473659 A/G cg04102620 chr4:3473595 DOK7 0.34 5.45 0.32 1.15e-7 LDL cholesterol;Triglyceride levels;Triglycerides;Cholesterol, total; CESC cis rs1570884 0.536 rs1359541 chr13:50158939 A/G cg08779649 chr13:50194554 NA 0.37 6.37 0.36 8.27e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs9916302 0.904 rs9894500 chr17:37515735 G/C cg15445000 chr17:37608096 MED1 -0.41 -6.6 -0.38 2.18e-10 Glomerular filtration rate (creatinine); CESC trans rs7246760 0.867 rs58461110 chr19:9833390 G/A cg02900749 chr2:68251473 NA -0.85 -7.44 -0.42 1.38e-12 Pursuit maintenance gain; CESC cis rs9815354 0.669 rs113059632 chr3:41932858 G/A cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs992157 0.835 rs4674283 chr2:219144254 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.67 -8.69 -0.47 3.72e-16 Colorectal cancer; CESC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.65 8.99 0.48 4.96e-17 Menopause (age at onset); CESC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg25405998 chr7:65216604 CCT6P1 0.45 5.3 0.31 2.43e-7 Aortic root size; CESC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg02221750 chr19:17393354 ANKLE1 -0.5 -6.08 -0.35 4.11e-9 Systemic lupus erythematosus; CESC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg06873352 chr17:61820015 STRADA 0.7 12.06 0.6 5.25e-27 Prudent dietary pattern; CESC cis rs11048434 0.736 rs2377672 chr12:9112414 A/G cg23795048 chr12:9217529 LOC144571 0.36 5.53 0.32 7.76e-8 Sjögren's syndrome; CESC cis rs4237845 0.537 rs1599931 chr12:58258850 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.49 5.48 0.32 9.9e-8 Intelligence (multi-trait analysis); CESC cis rs6087990 0.748 rs4911255 chr20:31357580 A/T cg13636640 chr20:31349939 DNMT3B 0.92 16.3 0.71 7.35e-42 Ulcerative colitis; CESC cis rs992157 0.731 rs1399132 chr2:219159770 G/A cg00012203 chr2:219082015 ARPC2 0.75 9.97 0.52 4.31e-20 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04774374 chr7:128379134 CALU 0.58 6.91 0.39 3.63e-11 Gut microbiome composition (summer); CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg26354017 chr1:205819088 PM20D1 0.97 17.12 0.72 9.23e-45 Menarche (age at onset); CESC cis rs2304069 0.826 rs245076 chr5:149350648 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.66 9.0 0.48 4.47e-17 HIV-1 control; CESC cis rs8017423 0.967 rs2277514 chr14:90723059 T/C cg14092571 chr14:90743983 NA -0.55 -8.31 -0.45 5.06e-15 Mortality in heart failure; CESC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg19592336 chr6:28129416 ZNF389 0.49 5.83 0.34 1.6e-8 Depression; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26216002 chr1:10093067 UBE4B -0.45 -6.2 -0.36 2.15e-9 Gut microbiota (bacterial taxa); CESC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg03452623 chr4:187889614 NA -0.89 -14.8 -0.67 1.53e-36 Lobe attachment (rater-scored or self-reported); CESC trans rs11148252 0.553 rs7999849 chr13:53249414 A/G cg18335740 chr13:41363409 SLC25A15 0.51 6.99 0.39 2.17e-11 Lewy body disease; CESC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg18876405 chr7:65276391 NA -0.53 -7.38 -0.41 2.05e-12 Aortic root size; CESC cis rs7762018 1.000 rs1127489 chr6:170107702 C/T cg13891659 chr6:170190454 C6orf122;C6orf208 0.53 5.49 0.32 9.38e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9486715 0.964 rs6921480 chr6:97066329 C/G cg06623918 chr6:96969491 KIAA0776 -0.86 -12.58 -0.61 9.16e-29 Headache; CESC cis rs79349575 0.783 rs15563 chr17:47005193 A/G cg16584676 chr17:46985605 UBE2Z 0.53 6.68 0.38 1.4e-10 Type 2 diabetes; CESC cis rs2637266 1.000 rs7474960 chr10:78359021 C/T cg18941641 chr10:78392320 NA 0.41 7.89 0.44 7.87e-14 Pulmonary function; CESC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.33 -5.94 -0.34 9.12e-9 Bipolar disorder; CESC trans rs11992162 1.000 rs11994417 chr8:11833262 G/A cg15556689 chr8:8085844 FLJ10661 0.55 6.28 0.36 1.37e-9 Monocyte count; CESC cis rs1355223 0.902 rs836466 chr11:34737366 G/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.44 -0.37 5.45e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6138458 1.000 rs6707 chr20:24944166 C/T cg06937882 chr20:24974362 C20orf3 -0.35 -5.06 -0.3 7.72e-7 Blood protein levels; CESC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg17077180 chr1:38461687 NA -0.43 -5.9 -0.34 1.14e-8 Coronary artery disease; CESC cis rs919433 0.929 rs7592511 chr2:198177974 A/G cg03934865 chr2:198174659 NA -0.48 -7.53 -0.42 7.95e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg10053473 chr17:62856997 LRRC37A3 0.61 6.68 0.38 1.43e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs910316 0.836 rs6574212 chr14:75671659 G/A cg08847533 chr14:75593920 NEK9 -0.94 -16.15 -0.7 2.56e-41 Height; CESC cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg02487422 chr3:49467188 NICN1 0.4 5.11 0.3 6.09e-7 Parkinson's disease; CESC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg18225595 chr11:63971243 STIP1 0.73 10.09 0.53 1.74e-20 Platelet count; CESC cis rs796364 0.760 rs1569178 chr2:201024512 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.74 -6.24 -0.36 1.76e-9 Schizophrenia; CESC cis rs12042107 0.841 rs1008078 chr1:91189731 C/T cg13456504 chr1:91191583 NA -0.33 -5.7 -0.33 3.14e-8 Educational attainment; CESC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg19163074 chr7:65112434 INTS4L2 0.5 6.44 0.37 5.52e-10 Calcium levels; CESC cis rs4722166 0.630 rs4722169 chr7:22785419 C/T cg13104385 chr7:22767384 IL6 0.48 6.36 0.36 8.7e-10 Lung cancer; CESC cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg09658497 chr7:2847517 GNA12 -0.38 -5.79 -0.34 1.96e-8 Height; CESC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg10541313 chr22:46663664 TTC38 0.74 5.91 0.34 1.02e-8 LDL cholesterol;Cholesterol, total; CESC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg15052019 chr19:19431593 KIAA0892;SF4 -0.4 -5.07 -0.3 7.59e-7 Tonsillectomy; CESC cis rs11098499 0.954 rs1546505 chr4:120241224 A/G cg09307838 chr4:120376055 NA 0.89 12.09 0.6 4.26e-27 Corneal astigmatism; CESC cis rs11642862 1.000 rs11642466 chr16:30781942 A/G cg02466173 chr16:30829666 NA -0.6 -6.08 -0.35 4.15e-9 Tonsillectomy; CESC cis rs13064411 0.696 rs869342 chr3:113226330 C/T cg18753928 chr3:113234510 CCDC52 -0.5 -6.13 -0.35 3.23e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs4974559 0.739 rs28429103 chr4:1320023 G/A cg02980000 chr4:1222292 CTBP1 0.78 7.02 0.4 1.86e-11 Systolic blood pressure; CESC cis rs11190604 1.000 rs10883506 chr10:102289743 C/G cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs7551222 0.749 rs10900600 chr1:204559707 G/T cg20240347 chr1:204465584 NA -0.28 -5.78 -0.33 2.09e-8 Schizophrenia; CESC cis rs2228479 0.717 rs17233678 chr16:89809962 T/C cg06558623 chr16:89946397 TCF25 1.17 9.44 0.5 1.96e-18 Skin colour saturation; CESC cis rs12995491 0.843 rs1878809 chr2:88518315 C/T cg14558114 chr2:88469736 THNSL2 -0.53 -7.35 -0.41 2.51e-12 Response to metformin (IC50); CESC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg23758822 chr17:41437982 NA 1.03 15.32 0.69 2.32e-38 Menopause (age at onset); CESC cis rs6582630 0.519 rs8189609 chr12:38281408 A/G cg13010199 chr12:38710504 ALG10B 0.52 6.38 0.36 8.04e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg05535760 chr7:792225 HEATR2 0.94 10.83 0.55 7.19e-23 Cerebrospinal P-tau181p levels; CESC cis rs763121 0.853 rs3747172 chr22:39067524 A/G cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg13298116 chr11:62369859 EML3;MTA2 0.53 7.38 0.41 2.06e-12 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs1799949 0.965 rs799912 chr17:41257134 T/C cg23758822 chr17:41437982 NA 0.99 17.68 0.74 1.01e-46 Menopause (age at onset); CESC cis rs4555082 0.834 rs2735819 chr14:105713449 C/T cg13114125 chr14:105738426 BRF1 -0.8 -9.77 -0.51 1.83e-19 Mean platelet volume;Platelet distribution width; CESC cis rs888194 0.651 rs6606734 chr12:110013639 T/G cg19025524 chr12:109796872 NA -0.34 -5.08 -0.3 7.25e-7 Neuroticism; CESC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg15782153 chr7:917662 C7orf20 0.52 5.72 0.33 2.91e-8 Cerebrospinal P-tau181p levels; CESC cis rs2046867 0.818 rs62249874 chr3:72911202 G/C cg25664220 chr3:72788482 NA -0.45 -6.48 -0.37 4.56e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1256061 0.624 rs1152586 chr14:64690784 T/C cg23250157 chr14:64679961 SYNE2 0.53 7.51 0.42 9.13e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2302190 0.882 rs7213415 chr17:56672433 C/G cg25885038 chr17:56607967 SEPT4 -0.4 -5.43 -0.32 1.27e-7 Vitamin D levels; CESC cis rs644799 1.000 rs527899 chr11:95529242 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs868036 0.681 rs2241423 chr15:68086838 G/A cg08079166 chr15:68083412 MAP2K5 0.35 5.1 0.3 6.47e-7 Restless legs syndrome; CESC cis rs4699052 0.625 rs7695593 chr4:104263783 A/T cg16532752 chr4:104119610 CENPE -0.38 -5.32 -0.31 2.19e-7 Testicular germ cell tumor; CESC cis rs2228479 0.850 rs62056068 chr16:89909737 C/T cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs4853012 1.000 rs4853012 chr2:74361290 G/A cg01017244 chr2:74357527 NA 0.72 8.74 0.47 2.8e-16 Gestational age at birth (maternal effect); CESC cis rs78456975 0.941 rs13412229 chr2:1520381 C/T cg01028140 chr2:1542097 TPO -0.57 -5.49 -0.32 9.47e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9488822 0.636 rs11153592 chr6:116330574 T/C cg05304507 chr6:116381966 FRK 0.25 6.49 0.37 4.22e-10 Cholesterol, total;LDL cholesterol; CESC cis rs7100689 0.622 rs2342816 chr10:82086546 G/A cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 4.91e-14 Post bronchodilator FEV1; CESC cis rs858239 0.570 rs10235467 chr7:23148808 C/T cg23682824 chr7:23144976 KLHL7 0.54 7.45 0.42 1.32e-12 Cerebrospinal fluid biomarker levels; CESC cis rs13034020 0.522 rs13017457 chr2:61248645 G/A cg18625361 chr2:61244694 PEX13;PUS10 0.66 5.9 0.34 1.13e-8 Hodgkin's lymphoma; CESC cis rs12681288 0.862 rs7814231 chr8:1021103 A/G cg15309053 chr8:964076 NA 0.33 5.58 0.32 5.82e-8 Schizophrenia; CESC cis rs1670533 1.000 rs10031302 chr4:1059664 G/A cg27284194 chr4:1044797 NA 0.48 6.12 0.35 3.43e-9 Recombination rate (females); CESC cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg21881798 chr11:8931708 C11orf17;ST5 0.5 7.97 0.44 4.84e-14 Hemoglobin concentration; CESC cis rs4803468 1.000 rs284656 chr19:41929251 T/C cg08639244 chr19:41945921 ATP5SL -0.42 -5.11 -0.3 6.12e-7 Height; CESC cis rs113835537 0.866 rs59566349 chr11:66365994 A/T cg22134325 chr11:66188745 NPAS4 0.52 5.9 0.34 1.13e-8 Airway imaging phenotypes; CESC cis rs2274273 0.967 rs2094102 chr14:55591098 T/C cg04306507 chr14:55594613 LGALS3 0.31 6.15 0.35 2.91e-9 Protein biomarker; CESC cis rs7264396 0.790 rs6060518 chr20:34217309 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.9 -0.59 1.96e-26 Total cholesterol levels; CESC cis rs2637266 0.714 rs7082421 chr10:78446313 G/A cg18941641 chr10:78392320 NA 0.4 7.28 0.41 3.76e-12 Pulmonary function; CESC cis rs6752107 0.936 rs6431660 chr2:234167234 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.46 6.34 0.36 1.01e-9 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09026481 chr5:74633022 HMGCR 0.59 6.37 0.36 8.55e-10 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg04414720 chr1:150670196 GOLPH3L 0.62 8.8 0.48 1.76e-16 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17150465 chr8:144897558 SCRIB 0.55 6.71 0.38 1.18e-10 Gut microbiome composition (summer); CESC cis rs56399783 0.901 rs11764225 chr7:2775607 G/A cg19731401 chr7:2775893 GNA12 0.67 6.12 0.35 3.39e-9 Childhood ear infection; CESC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.84 0.34 1.55e-8 Tonsillectomy; CESC cis rs1865721 0.804 rs7229401 chr18:73148127 T/G cg26385618 chr18:73139727 C18orf62 -0.51 -7.88 -0.44 8.26e-14 Intelligence; CESC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg04287289 chr16:89883240 FANCA -0.87 -14.96 -0.68 4.15e-37 Vitiligo; CESC cis rs7680126 0.596 rs4697714 chr4:10143786 A/T cg11266682 chr4:10021025 SLC2A9 -0.42 -5.94 -0.34 9.04e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg00166722 chr3:10149974 C3orf24 0.54 7.12 0.4 1.02e-11 Alzheimer's disease; CESC cis rs7772486 0.790 rs4314514 chr6:146260010 A/G cg23711669 chr6:146136114 FBXO30 -0.92 -13.3 -0.63 2.94e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.71e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 10.54 0.54 6.37e-22 Platelet count; CESC cis rs17253792 0.822 rs10136155 chr14:56049129 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.86 6.26 0.36 1.58e-9 Putamen volume; CESC cis rs9318086 0.648 rs9510927 chr13:24467641 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.49 6.93 0.39 3.23e-11 Myopia (pathological); CESC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg08704250 chr15:31115839 NA -0.68 -9.17 -0.49 1.35e-17 Huntington's disease progression; CESC cis rs708547 0.581 rs10020462 chr4:57825593 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.46 5.49 0.32 9.65e-8 Response to bleomycin (chromatid breaks); CESC cis rs7980687 0.662 rs585522 chr12:123550813 A/G cg05973401 chr12:123451056 ABCB9 0.62 6.99 0.39 2.27e-11 Height;Educational attainment;Head circumference (infant); CESC cis rs4911259 0.552 rs6058926 chr20:31465450 T/C cg13636640 chr20:31349939 DNMT3B -0.54 -7.47 -0.42 1.16e-12 Inflammatory bowel disease; CESC cis rs17826219 0.706 rs2322197 chr17:29105805 T/C cg19761014 chr17:28927070 LRRC37B2 0.71 5.97 0.34 7.65e-9 Body mass index; CESC cis rs7937682 0.632 rs11214037 chr11:111773296 C/T cg09085632 chr11:111637200 PPP2R1B 0.88 11.23 0.57 3.37e-24 Primary sclerosing cholangitis; CESC cis rs7851660 0.874 rs925487 chr9:100636398 C/T cg13688889 chr9:100608707 NA -0.62 -8.62 -0.47 6.13e-16 Strep throat; CESC cis rs763121 0.853 rs2179142 chr22:39037954 G/A cg21395723 chr22:39101663 GTPBP1 0.45 5.66 0.33 3.97e-8 Menopause (age at onset); CESC cis rs1448094 0.817 rs10863112 chr12:86330844 C/T cg02569458 chr12:86230093 RASSF9 0.45 6.43 0.37 5.79e-10 Major depressive disorder; CESC cis rs1152591 0.643 rs3020449 chr14:64773392 C/T cg21174375 chr14:64681225 SYNE2 -0.53 -6.95 -0.39 2.88e-11 Atrial fibrillation; CESC trans rs28549925 0.590 rs17136950 chr7:16994248 G/T cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.74e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs12477438 0.871 rs62156364 chr2:99695097 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.95 -0.44 5.45e-14 Chronic sinus infection; CESC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg00310523 chr12:86230176 RASSF9 0.35 5.44 0.32 1.21e-7 Major depressive disorder; CESC cis rs965469 1.000 rs6051807 chr20:3350485 A/G cg25506879 chr20:3388711 C20orf194 -0.58 -5.97 -0.34 7.49e-9 IFN-related cytopenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09090048 chr11:134093731 VPS26B;NCAPD3 -0.39 -6.19 -0.36 2.27e-9 Gambling; CESC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg10691866 chr7:65817282 TPST1 -0.33 -5.39 -0.31 1.58e-7 Aortic root size; CESC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.42 -0.41 1.59e-12 Total body bone mineral density; CESC cis rs8044995 0.706 rs111948678 chr16:68255959 G/A cg26727032 chr16:67993705 SLC12A4 -0.48 -5.18 -0.3 4.5e-7 Schizophrenia; CESC cis rs7726839 0.561 rs3915384 chr5:573395 G/T cg16447950 chr5:562315 NA -0.54 -5.98 -0.34 7.29e-9 Obesity-related traits; CESC cis rs6964587 1.000 rs4727267 chr7:91570290 G/C cg17063962 chr7:91808500 NA -0.57 -7.62 -0.42 4.53e-13 Breast cancer; CESC cis rs6540559 0.543 rs672819 chr1:210436404 T/A cg23283495 chr1:209979779 IRF6 0.43 5.19 0.3 4.16e-7 Cleft lip with or without cleft palate; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg14751398 chr6:20402153 E2F3 0.47 6.03 0.35 5.57e-9 Tetralogy of Fallot; CESC cis rs4144743 0.759 rs16969966 chr17:45318452 G/T cg18085866 chr17:45331354 ITGB3 -0.57 -5.66 -0.33 3.88e-8 Body mass index; CESC cis rs6912958 0.781 rs6454631 chr6:88225863 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.55 -0.37 3.01e-10 Monocyte percentage of white cells; CESC cis rs7917772 0.503 rs2031602 chr10:104307955 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.56 7.87 0.44 9.28e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs79839061 0.656 rs11726508 chr4:888937 C/T cg04824913 chr4:887549 GAK 0.6 5.16 0.3 4.96e-7 Intelligence (multi-trait analysis); CESC cis rs868036 1.000 rs3784719 chr15:68098180 C/T cg08079166 chr15:68083412 MAP2K5 0.44 6.94 0.39 2.94e-11 Restless legs syndrome; CESC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.61 7.83 0.43 1.21e-13 Menopause (age at onset); CESC cis rs61931739 0.746 rs1687003 chr12:34170099 T/A cg19457237 chr12:34500585 NA -0.41 -5.63 -0.33 4.55e-8 Morning vs. evening chronotype; CESC cis rs17001868 0.568 rs2280790 chr22:40745181 T/C cg07138101 chr22:40742427 ADSL 0.55 5.2 0.3 3.96e-7 Mammographic density (dense area); CESC cis rs2832191 0.967 rs2832216 chr21:30521921 C/T cg24692254 chr21:30365293 RNF160 0.73 10.88 0.56 4.79e-23 Dental caries; CESC cis rs5498 0.809 rs1056538 chr19:10402938 G/A cg08845333 chr19:10403403 ICAM5 0.4 5.49 0.32 9.2e-8 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs7116495 1.000 rs949325 chr11:71729656 A/G cg26138937 chr11:71823887 C11orf51 -0.77 -6.35 -0.36 9.29e-10 Severe influenza A (H1N1) infection; CESC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.26 0.31 3e-7 Menopause (age at onset); CESC cis rs4604732 0.631 rs4411161 chr1:247632374 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.43 5.42 0.32 1.37e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs8017423 0.569 rs10141476 chr14:90823351 C/T cg14092571 chr14:90743983 NA 0.44 6.77 0.38 8.12e-11 Mortality in heart failure; CESC cis rs9457247 0.905 rs444210 chr6:167390242 A/G cg23791538 chr6:167370224 RNASET2 -0.62 -8.79 -0.47 1.99e-16 Crohn's disease; CESC trans rs61931739 0.500 rs28692887 chr12:34457075 G/A cg13010199 chr12:38710504 ALG10B 0.48 6.28 0.36 1.38e-9 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17903999 chr18:56338584 MALT1 0.58 6.65 0.38 1.72e-10 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.48 0.64 7.06e-32 Prudent dietary pattern; CESC cis rs35306767 0.714 rs28512382 chr10:1092195 G/C cg26597838 chr10:835615 NA 0.61 5.91 0.34 1.07e-8 Eosinophil percentage of granulocytes; CESC cis rs9916302 0.861 rs11078913 chr17:37671714 G/T cg15445000 chr17:37608096 MED1 0.4 6.63 0.38 1.89e-10 Glomerular filtration rate (creatinine); CESC cis rs6541297 1.000 rs4846838 chr1:230281618 G/A cg05784532 chr1:230284198 GALNT2 0.5 5.61 0.33 5.13e-8 Coronary artery disease; CESC cis rs10078 0.515 rs1053299 chr5:470760 G/A cg08916839 chr5:415575 AHRR 0.58 6.76 0.38 8.54e-11 Fat distribution (HIV); CESC cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.82e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg11890956 chr21:40555474 PSMG1 0.93 9.99 0.52 3.81e-20 Cognitive function; CESC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.67 0.33 3.77e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs72945132 0.882 rs7122057 chr11:70201430 T/C cg14191688 chr11:70257035 CTTN 0.43 5.41 0.32 1.42e-7 Coronary artery disease; CESC cis rs10754283 0.840 rs6428560 chr1:90102462 A/T cg21401794 chr1:90099060 LRRC8C 0.71 9.51 0.5 1.24e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg10691866 chr7:65817282 TPST1 -0.32 -5.04 -0.3 8.78e-7 Aortic root size; CESC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg04944784 chr2:26401820 FAM59B 0.96 10.55 0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs7129220 0.588 rs61878625 chr11:10123136 T/C cg01453529 chr11:10209919 SBF2 -0.49 -5.67 -0.33 3.71e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7937682 1.000 rs11213980 chr11:111562692 A/T cg22437258 chr11:111473054 SIK2 -0.55 -6.47 -0.37 4.72e-10 Primary sclerosing cholangitis; CESC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg11764359 chr7:65958608 NA 0.68 8.78 0.47 2.08e-16 Aortic root size; CESC cis rs11098499 0.722 rs10025925 chr4:120271744 A/T cg09307838 chr4:120376055 NA 0.77 10.19 0.53 8.72e-21 Corneal astigmatism; CESC cis rs11112613 0.775 rs12371537 chr12:105971425 T/C cg03607813 chr12:105948248 NA 0.56 6.26 0.36 1.58e-9 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs116095464 0.764 rs10069197 chr5:230822 G/C cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.69 0.33 3.34e-8 Breast cancer; CESC cis rs1729951 0.575 rs1682333 chr3:136688618 G/A cg03617693 chr3:136751559 NA 0.38 5.32 0.31 2.21e-7 Neuroticism; CESC cis rs1124376 1.000 rs10084714 chr3:20183332 T/C cg05072819 chr3:20081367 KAT2B 0.51 5.56 0.32 6.54e-8 Bipolar disorder and schizophrenia; CESC cis rs1355223 0.872 rs1258466 chr11:34730066 T/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.41 -0.37 6.58e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 9.9 0.52 7.25e-20 Prudent dietary pattern; CESC cis rs4950928 0.823 rs2153101 chr1:203168474 A/T cg14085262 chr1:203155938 CHI3L1 -0.49 -5.55 -0.32 6.96e-8 YKL-40 levels; CESC cis rs9300255 0.510 rs1727323 chr12:123698790 T/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.51 -0.37 3.65e-10 Neutrophil percentage of white cells; CESC cis rs9811920 0.535 rs792831 chr3:99473720 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.34 -5.45 -0.32 1.14e-7 Axial length; CESC cis rs3820928 0.839 rs12151848 chr2:227859326 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -5.45 -0.32 1.12e-7 Pulmonary function; CESC cis rs9815354 0.812 rs73077358 chr3:41850005 C/T cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs5747327 0.804 rs2401165 chr22:18147071 C/T cg19898043 chr22:18121309 BCL2L13 -0.41 -5.18 -0.3 4.41e-7 Myeloid white cell count;Granulocyte count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03885022 chr7:92158293 C7orf64;PEX1 -0.46 -6.44 -0.37 5.48e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9303280 0.776 rs11078926 chr17:38062976 G/A cg20243544 chr17:37824526 PNMT 0.53 6.87 0.39 4.54e-11 Self-reported allergy; CESC cis rs4722166 0.695 rs7787893 chr7:22774437 A/G cg05265849 chr7:22767390 IL6 0.44 6.16 0.35 2.68e-9 Lung cancer; CESC cis rs858239 0.669 rs6461688 chr7:23116615 G/A cg27449745 chr7:23145252 KLHL7 -0.46 -5.83 -0.34 1.58e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7210086 0.768 rs4485409 chr17:70640381 C/T cg04206342 chr17:70636940 NA -0.28 -5.15 -0.3 5.13e-7 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09645772 chr5:180688272 TRIM52 0.6 6.65 0.38 1.63e-10 Gut microbiome composition (summer); CESC cis rs864537 0.676 rs2056625 chr1:167420299 G/A cg22356347 chr1:167427500 CD247 -0.39 -8.01 -0.44 3.69e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.72 0.38 1.13e-10 Bipolar disorder; CESC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg18190219 chr22:46762943 CELSR1 -0.59 -6.7 -0.38 1.23e-10 LDL cholesterol;Cholesterol, total; CESC cis rs910316 0.967 rs8013444 chr14:75661981 A/G cg11812906 chr14:75593930 NEK9 -0.85 -13.99 -0.65 1.13e-33 Height; CESC cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg19077165 chr18:44547161 KATNAL2 -0.58 -8.68 -0.47 4e-16 Personality dimensions; CESC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg11890956 chr21:40555474 PSMG1 1.18 24.03 0.83 1.59e-68 Cognitive function; CESC cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg13298116 chr11:62369859 EML3;MTA2 0.53 7.41 0.41 1.67e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2637266 0.600 rs11591359 chr10:78339907 G/A cg18941641 chr10:78392320 NA -0.35 -5.42 -0.32 1.31e-7 Pulmonary function; CESC cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg12292205 chr6:26970375 C6orf41 -0.49 -5.63 -0.33 4.53e-8 Intelligence (multi-trait analysis); CESC cis rs9640161 0.830 rs36069544 chr7:150061538 G/A cg21361702 chr7:150065534 REPIN1 0.69 8.27 0.45 6.42e-15 Blood protein levels;Circulating chemerin levels; CESC cis rs748404 0.660 rs2467738 chr15:43739936 T/A cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.38 0.46 3.14e-15 Lung cancer; CESC cis rs9287719 0.967 rs6432122 chr2:10753844 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs12479064 0.724 rs3087403 chr2:100058870 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.95 -0.44 5.33e-14 Chronic sinus infection; CESC cis rs926938 0.608 rs360612 chr1:115394747 G/A cg12756093 chr1:115239321 AMPD1 0.46 6.21 0.36 2.03e-9 Autism; CESC cis rs7267979 0.966 rs2257705 chr20:25264664 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs3026445 0.925 rs73206861 chr12:110798562 A/T cg12870014 chr12:110450643 ANKRD13A 0.42 5.2 0.3 4.06e-7 QT interval; CESC cis rs10744422 1.000 rs7138398 chr12:123341833 G/C cg25930673 chr12:123319894 HIP1R -0.81 -6.32 -0.36 1.09e-9 Schizophrenia; CESC trans rs61931739 0.517 rs12816423 chr12:34067736 G/A cg26384229 chr12:38710491 ALG10B 0.6 8.38 0.46 3.12e-15 Morning vs. evening chronotype; CESC cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg20503657 chr10:835505 NA 0.76 8.01 0.44 3.56e-14 Eosinophil percentage of granulocytes; CESC cis rs965469 0.779 rs6037581 chr20:3351595 C/T cg17110299 chr20:3385021 C20orf194 0.39 5.12 0.3 5.87e-7 IFN-related cytopenia; CESC cis rs3015469 0.550 rs2236316 chr14:51224417 C/G cg26011998 chr14:51135199 SAV1 0.47 5.21 0.31 3.72e-7 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs12999616 0.948 rs35958372 chr2:98330858 T/C cg26665480 chr2:98280029 ACTR1B 0.58 5.71 0.33 2.97e-8 Colorectal cancer; CESC cis rs962856 0.575 rs598108 chr2:67656232 G/A cg09028215 chr2:67624308 ETAA1 -0.43 -5.23 -0.31 3.45e-7 Pancreatic cancer; CESC cis rs6460942 0.730 rs73053536 chr7:12323131 C/G cg20607287 chr7:12443886 VWDE -0.78 -8.01 -0.44 3.61e-14 Coronary artery disease; CESC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC cis rs11650494 0.908 rs75904857 chr17:47370449 T/G cg08112188 chr17:47440006 ZNF652 1.22 8.11 0.45 1.93e-14 Prostate cancer; CESC cis rs8180040 1.000 rs7613282 chr3:47389409 C/T cg27129171 chr3:47204927 SETD2 -0.66 -10.19 -0.53 8.43e-21 Colorectal cancer; CESC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg17294928 chr15:75287854 SCAMP5 0.49 6.17 0.35 2.54e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs4237845 0.586 rs4760174 chr12:58320436 G/A cg02175503 chr12:58329896 NA 0.93 15.08 0.68 1.59e-37 Intelligence (multi-trait analysis); CESC cis rs367615 0.552 rs7720036 chr5:108710699 A/G cg17395555 chr5:108820864 NA -0.52 -8.52 -0.46 1.24e-15 Colorectal cancer (SNP x SNP interaction); CESC cis rs8077889 1.000 rs2880329 chr17:41866168 T/A cg26893861 chr17:41843967 DUSP3 0.85 9.86 0.52 1e-19 Triglycerides; CESC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg18446336 chr7:2847575 GNA12 -0.36 -5.64 -0.33 4.32e-8 Height; CESC cis rs258892 0.947 rs250517 chr5:72200626 G/C cg21869765 chr5:72125136 TNPO1 0.45 5.62 0.33 4.9e-8 Small cell lung carcinoma; CESC cis rs72781680 1.000 rs11553491 chr2:24225901 G/C cg20701182 chr2:24300061 SF3B14 0.74 6.38 0.36 7.9e-10 Lymphocyte counts; CESC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 9.6 0.51 6.59e-19 Platelet count; CESC cis rs17433780 0.892 rs72726528 chr1:89455980 C/A cg09516651 chr1:89888402 LOC400759 0.67 9.06 0.49 2.92e-17 Carotid intima media thickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22818988 chr3:3168509 TRNT1 0.58 6.93 0.39 3.17e-11 Gut microbiome composition (summer); CESC cis rs888194 0.690 rs888192 chr12:109995097 C/T cg19025524 chr12:109796872 NA 0.34 5.17 0.3 4.56e-7 Neuroticism; CESC cis rs4689388 0.890 rs9993624 chr4:6286528 C/T cg25554036 chr4:6271136 WFS1 0.53 8.62 0.47 6.35e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7635838 0.686 rs347589 chr3:11288419 A/G cg00170343 chr3:11313890 ATG7 0.52 7.21 0.41 5.79e-12 HDL cholesterol; CESC cis rs644799 1.000 rs593665 chr11:95574302 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.52 0.37 3.44e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg08736216 chr1:53307985 ZYG11A -0.4 -6.53 -0.37 3.32e-10 Monocyte count; CESC cis rs9888739 0.800 rs1143683 chr16:31336888 A/G cg15817542 chr16:31343056 ITGAM 0.49 7.29 0.41 3.57e-12 Systemic lupus erythematosus; CESC cis rs7408868 1.000 rs10416389 chr19:15278674 G/C cg14696996 chr19:15285081 NOTCH3 1.11 11.94 0.59 1.43e-26 Pulse pressure; CESC cis rs10851478 0.872 rs12907944 chr15:49906971 G/A cg08060515 chr15:49448048 GALK2;COPS2 0.43 5.26 0.31 3e-7 Oral cavity cancer; CESC trans rs7095944 0.614 rs10901816 chr10:126440395 G/A cg27222157 chr11:66382978 RBM14 0.38 6.13 0.35 3.17e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00009214 chr12:16064569 DERA 0.66 7.3 0.41 3.42e-12 Gut microbiome composition (summer); CESC cis rs2295499 0.673 rs55993221 chr4:2704910 G/T cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.24 -0.31 3.34e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs2247341 0.965 rs2854913 chr4:1723137 A/T cg07465881 chr4:1713556 SLBP -0.51 -6.21 -0.36 2.04e-9 Hip circumference adjusted for BMI;Height; CESC cis rs6500602 0.598 rs3859155 chr16:4593741 A/C cg08645402 chr16:4508243 NA -0.45 -7.2 -0.4 6.32e-12 Schizophrenia; CESC cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg17775713 chr3:133465469 TF 0.33 6.0 0.35 6.57e-9 Iron status biomarkers (transferrin levels); CESC cis rs9788682 0.747 rs2568499 chr15:78722359 T/C cg24631222 chr15:78858424 CHRNA5 -0.6 -6.99 -0.39 2.2e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7301826 0.627 rs73162873 chr12:131296013 A/G cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14584159 chr10:134351371 INPP5A 0.65 7.81 0.43 1.34e-13 Gut microbiome composition (summer); CESC cis rs9325144 0.560 rs2013804 chr12:38631079 C/T cg26384229 chr12:38710491 ALG10B -0.61 -9.62 -0.51 5.7e-19 Morning vs. evening chronotype; CESC cis rs3091242 0.900 rs1883427 chr1:25744468 C/T cg02931644 chr1:25747376 RHCE 0.42 6.98 0.39 2.36e-11 Erythrocyte sedimentation rate; CESC trans rs1814175 0.645 rs866427 chr11:49923853 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs4319547 0.915 rs10734924 chr12:123018894 T/G cg05707623 chr12:122985044 ZCCHC8 -0.59 -6.72 -0.38 1.11e-10 Body mass index; CESC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Lung function (FEV1); CESC cis rs412050 0.547 rs61757982 chr22:22113740 A/G cg17089214 chr22:22089827 YPEL1 0.71 6.1 0.35 3.78e-9 Attention deficit hyperactivity disorder; CESC cis rs6545883 0.929 rs6545873 chr2:61733012 T/C cg15711740 chr2:61764176 XPO1 -0.43 -5.4 -0.31 1.47e-7 Tuberculosis; CESC cis rs709400 0.663 rs7158822 chr14:103887868 C/T cg12935359 chr14:103987150 CKB -0.5 -7.3 -0.41 3.28e-12 Body mass index; CESC cis rs7605827 0.930 rs11676115 chr2:15602962 G/A cg19274914 chr2:15703543 NA 0.34 6.09 0.35 3.92e-9 Educational attainment (years of education); CESC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg08888203 chr3:10149979 C3orf24 -0.52 -6.96 -0.39 2.65e-11 Alzheimer's disease; CESC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg00310523 chr12:86230176 RASSF9 0.35 5.56 0.32 6.53e-8 Major depressive disorder; CESC cis rs9911578 0.867 rs72628394 chr17:57121313 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.09 -0.3 6.92e-7 Intelligence (multi-trait analysis); CESC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.63 -0.33 4.68e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg22143856 chr6:28129313 ZNF389 0.46 5.83 0.34 1.58e-8 Depression; CESC cis rs501120 0.733 rs587375 chr10:44745808 T/C cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.17e-11 Coronary artery disease;Coronary heart disease; CESC cis rs9611565 0.545 rs5758432 chr22:42111693 T/C cg06634786 chr22:41940651 POLR3H 0.67 6.57 0.37 2.64e-10 Vitiligo; CESC cis rs62064224 0.714 rs8074594 chr17:30632998 G/A cg18200150 chr17:30822561 MYO1D 0.38 5.14 0.3 5.46e-7 Schizophrenia; CESC cis rs8114671 0.836 rs62213676 chr20:33612676 T/A cg24642439 chr20:33292090 TP53INP2 -0.45 -5.44 -0.32 1.19e-7 Height; CESC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg10862848 chr6:42927986 GNMT -0.25 -6.39 -0.37 7.35e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs3845702 0.736 rs1904850 chr2:180852767 A/G cg01881094 chr2:180872142 CWC22 -1.12 -10.13 -0.53 1.31e-20 Schizophrenia; CESC trans rs1814175 0.647 rs1404157 chr11:49917301 G/C cg03929089 chr4:120376271 NA -0.72 -9.28 -0.5 6.08e-18 Height; CESC cis rs9815354 0.951 rs1716679 chr3:41905339 T/C cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg12288994 chr5:1860383 NA 0.4 6.71 0.38 1.21e-10 Cardiovascular disease risk factors; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg20725035 chr3:148709344 GYG1 -0.45 -6.79 -0.38 7.22e-11 Breast cancer; CESC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg04772025 chr11:68637568 NA 0.55 6.49 0.37 4.17e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11039798 0.588 rs61932767 chr11:48704806 C/T cg15704280 chr7:45808275 SEPT13 0.62 6.6 0.38 2.24e-10 Axial length; CESC cis rs67311347 1.000 rs1454497 chr3:40496326 C/T cg01475735 chr3:40494733 NA 0.46 5.85 0.34 1.45e-8 Renal cell carcinoma; CESC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg05564831 chr3:52568323 NT5DC2 0.45 6.88 0.39 4.31e-11 Bipolar disorder; CESC cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg08847533 chr14:75593920 NEK9 -0.91 -15.97 -0.7 1.08e-40 Height; CESC trans rs875971 0.965 rs28682868 chr7:65689809 C/T cg26939375 chr7:64535504 NA -0.47 -6.15 -0.35 2.89e-9 Aortic root size; CESC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg04398451 chr17:18023971 MYO15A 0.68 9.89 0.52 7.75e-20 Total body bone mineral density; CESC cis rs1538970 0.924 rs12037201 chr1:45941349 G/T cg24296786 chr1:45957014 TESK2 -0.46 -5.21 -0.31 3.71e-7 Platelet count; CESC cis rs9487051 0.676 rs9386788 chr6:109600523 C/T cg12927641 chr6:109611667 NA 0.37 5.6 0.33 5.3e-8 Reticulocyte fraction of red cells; CESC cis rs8099014 0.731 rs9966665 chr18:56099407 A/C cg12827950 chr18:55968429 NEDD4L 0.5 5.55 0.32 6.84e-8 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16284168 chr7:99698217 MCM7;AP4M1 -0.54 -6.05 -0.35 4.9e-9 Gut microbiome composition (summer); CESC cis rs9660992 0.686 rs1668870 chr1:205239031 C/G cg00857998 chr1:205179979 DSTYK 0.47 5.35 0.31 1.87e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs698813 0.604 rs4953077 chr2:44481207 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 5.69 0.33 3.44e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs7945705 0.935 rs11042103 chr11:8888700 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.36 5.76 0.33 2.38e-8 Hemoglobin concentration; CESC cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.43 5.66 0.33 3.98e-8 Personality dimensions; CESC cis rs6539267 0.741 rs7314289 chr12:106686260 A/C cg00173435 chr12:106696525 TCP11L2 0.69 8.06 0.44 2.58e-14 Tourette syndrome; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21302562 chr1:44497012 SLC6A9 -0.52 -6.33 -0.36 1.04e-9 Ulcerative colitis; CESC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg11890956 chr21:40555474 PSMG1 1.09 16.66 0.72 4.13e-43 Cognitive function; CESC cis rs17376456 0.597 rs7728825 chr5:93384594 T/C cg25358565 chr5:93447407 FAM172A -0.47 -5.49 -0.32 9.61e-8 Diabetic retinopathy; CESC cis rs12541635 0.966 rs11782609 chr8:106967919 G/A cg10147462 chr8:107024639 NA 0.39 5.34 0.31 2.02e-7 Age of smoking initiation; CESC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.03 -0.35 5.44e-9 Parkinson's disease; CESC cis rs3793683 0.571 rs12781152 chr10:134590257 G/C cg27286337 chr10:134555280 INPP5A 0.7 8.14 0.45 1.6e-14 Migraine; CESC cis rs2235544 0.565 rs635509 chr1:54469227 A/G cg25741118 chr1:54482237 LDLRAD1 0.24 5.92 0.34 9.71e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26352439 chr17:157043 RPH3AL -0.54 -6.84 -0.39 5.37e-11 Gut microbiome composition (summer); CESC cis rs9916302 0.718 rs10445306 chr17:37591422 A/G cg15445000 chr17:37608096 MED1 0.41 6.72 0.38 1.1e-10 Glomerular filtration rate (creatinine); CESC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg07507251 chr3:52567010 NT5DC2 0.31 5.43 0.32 1.27e-7 Bipolar disorder; CESC cis rs6460942 0.908 rs78682952 chr7:12284886 C/A cg06484146 chr7:12443880 VWDE -0.57 -6.01 -0.35 6.03e-9 Coronary artery disease; CESC cis rs870825 0.616 rs7692367 chr4:185651056 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.74e-11 Blood protein levels; CESC cis rs3617 0.539 rs4687689 chr3:52948674 A/C cg07507251 chr3:52567010 NT5DC2 -0.35 -5.79 -0.34 1.97e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23815043 chr16:88729854 MGC23284;MVD -0.56 -6.21 -0.36 2.08e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs62408225 1.000 rs17513531 chr6:90951239 C/T cg06866423 chr6:90926672 BACH2 0.48 5.73 0.33 2.73e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1348850 0.540 rs6737342 chr2:178419117 G/A cg22681709 chr2:178499509 PDE11A -0.53 -5.97 -0.34 7.5e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg13393036 chr8:95962371 TP53INP1 -0.48 -10.36 -0.54 2.51e-21 Type 2 diabetes; CESC cis rs6088580 0.524 rs6088569 chr20:33268199 G/A cg24642439 chr20:33292090 TP53INP2 -0.47 -5.48 -0.32 9.79e-8 Glomerular filtration rate (creatinine); CESC cis rs34779708 0.897 rs16935880 chr10:35415468 C/G cg03585969 chr10:35415529 CREM 0.76 10.01 0.52 3.26e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs17039065 0.920 rs17039099 chr4:109434574 C/T cg16022748 chr4:109541635 LOC285456;RPL34 0.67 6.15 0.35 2.81e-9 Gut microbiome composition (summer); CESC cis rs7254114 0.578 rs12980863 chr19:11309871 C/T cg02815516 chr19:11306319 KANK2 -0.44 -7.24 -0.41 4.81e-12 Immature fraction of reticulocytes; CESC cis rs16973500 0.808 rs57807129 chr16:71948043 T/C cg09427745 chr16:71932006 KIAA0174 -0.52 -5.3 -0.31 2.39e-7 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs6539267 0.885 rs34762209 chr12:106722466 T/C cg02476566 chr12:106696527 TCP11L2 0.5 5.45 0.32 1.15e-7 Tourette syndrome; CESC cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg04546413 chr19:29218101 NA 0.4 5.09 0.3 6.68e-7 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08889949 chr3:49044473 P4HTM;WDR6 -0.56 -6.39 -0.37 7.53e-10 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.09 10.99 0.56 2.16e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9858542 0.953 rs67216675 chr3:49493151 G/T cg03060546 chr3:49711283 APEH -0.54 -6.08 -0.35 4.07e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs1973993 0.967 rs10489741 chr1:96942406 G/A cg10631902 chr5:14652156 NA 0.55 7.58 0.42 5.89e-13 Weight; CESC cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.91 0.48 8.46e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs11098499 0.754 rs9991959 chr4:120253773 C/T cg09307838 chr4:120376055 NA -0.78 -10.68 -0.55 2.29e-22 Corneal astigmatism; CESC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 8.64 0.47 5.56e-16 Platelet count; CESC cis rs6083 0.549 rs11858020 chr15:58852422 A/T cg05156742 chr15:59063176 FAM63B 0.66 9.25 0.49 8.01e-18 Schizophrenia; CESC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.76 0.65 7.11e-33 Prudent dietary pattern; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg10950113 chr16:69166907 CHTF8;CIRH1A -0.46 -5.99 -0.35 6.63e-9 Height; CESC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg04282206 chr17:62833786 PLEKHM1P 0.55 6.62 0.38 1.98e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9322193 0.847 rs4870054 chr6:150169538 C/T cg09699651 chr6:150184138 LRP11 0.43 5.53 0.32 7.59e-8 Lung cancer; CESC cis rs4664304 0.629 rs3792168 chr2:160846472 T/C cg03641300 chr2:160917029 PLA2R1 -0.43 -5.82 -0.34 1.68e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs116095464 0.558 rs10036253 chr5:238519 A/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.31 0.31 2.3e-7 Breast cancer; CESC cis rs12220238 1.000 rs2279648 chr10:75867193 G/T cg19889307 chr10:75911429 ADK;AP3M1 0.69 6.33 0.36 1.06e-9 Soluble interleukin-2 receptor subunit alpha; CESC trans rs561341 1.000 rs55962687 chr17:30260369 C/T cg27661571 chr11:113659931 NA -0.75 -6.87 -0.39 4.57e-11 Hip circumference adjusted for BMI; CESC cis rs8058578 0.775 rs8046391 chr16:30836648 G/C cg02466173 chr16:30829666 NA -0.47 -7.63 -0.42 4.15e-13 Multiple myeloma; CESC trans rs656319 0.607 rs35437983 chr8:10005053 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -6.13 -0.35 3.19e-9 Myopia (pathological); CESC cis rs8028182 0.577 rs8023268 chr15:75814672 A/T cg20655648 chr15:75932815 IMP3 0.48 5.9 0.34 1.08e-8 Sudden cardiac arrest; CESC cis rs7208859 0.623 rs1061342 chr17:29114463 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.49 0.37 4.22e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg00624375 chr12:110841656 ANAPC7 -0.49 -6.33 -0.36 1.05e-9 Thyroid stimulating hormone; CESC cis rs9649465 1.000 rs13230294 chr7:123380821 T/C cg04330084 chr7:123175371 IQUB -0.38 -5.17 -0.3 4.64e-7 Migraine; CESC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg02574844 chr11:5959923 NA -0.46 -6.44 -0.37 5.57e-10 DNA methylation (variation); CESC cis rs9549367 0.789 rs912012 chr13:113886152 G/A cg18105134 chr13:113819100 PROZ -0.67 -8.17 -0.45 1.29e-14 Platelet distribution width; CESC cis rs9399135 0.967 rs4376365 chr6:135307740 T/C cg24558204 chr6:135376177 HBS1L 0.5 6.74 0.38 1.01e-10 Red blood cell count; CESC cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg20891283 chr12:69753455 YEATS4 -0.97 -16.47 -0.71 1.87e-42 Cerebrospinal fluid biomarker levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06240275 chr17:2239739 TSR1;SGSM2 -0.49 -6.2 -0.36 2.18e-9 Fibrinogen levels; CESC cis rs616402 0.527 rs604369 chr1:10567208 C/A cg17425144 chr1:10567563 PEX14 0.38 6.09 0.35 4.02e-9 Breast size; CESC cis rs1670533 0.932 rs610218 chr4:1080083 C/G cg27284194 chr4:1044797 NA 0.47 5.91 0.34 1.04e-8 Recombination rate (females); CESC cis rs7131987 0.675 rs2194515 chr12:29550383 T/C cg09582351 chr12:29534625 ERGIC2 0.35 5.54 0.32 7.23e-8 QT interval; CESC cis rs2070488 0.775 rs6599207 chr3:38554901 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.78 -12.49 -0.61 1.89e-28 Electrocardiographic conduction measures; CESC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg21963583 chr11:68658836 MRPL21 0.36 5.08 0.3 7.2e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23300289 chr9:132146083 NA 0.48 6.1 0.35 3.8e-9 Gut microbiota (bacterial taxa); CESC cis rs2797160 0.935 rs60515555 chr6:126000638 T/G cg05901451 chr6:126070800 HEY2 -0.45 -6.67 -0.38 1.44e-10 Endometrial cancer; CESC cis rs2235642 0.821 rs2281236 chr16:1603576 G/A cg03771183 chr16:1608904 IFT140 0.41 5.95 0.34 8.47e-9 Coronary artery disease; CESC cis rs7264396 0.790 rs10211771 chr20:34219994 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.67 0.43 3.29e-13 Total cholesterol levels; CESC cis rs7044106 0.791 rs747819 chr9:123488441 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.87 13.78 0.65 6.13e-33 Hip circumference adjusted for BMI; CESC cis rs9916302 0.904 rs7503069 chr17:37697128 C/G cg15445000 chr17:37608096 MED1 0.42 6.91 0.39 3.53e-11 Glomerular filtration rate (creatinine); CESC cis rs56235845 0.665 rs4976685 chr5:176766177 C/T cg06060754 chr5:176797920 RGS14 -0.44 -5.83 -0.34 1.61e-8 Hemoglobin concentration;Hematocrit; CESC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg07701084 chr6:150067640 NUP43 0.49 6.77 0.38 8.5e-11 Lung cancer; CESC cis rs5747327 1.000 rs5747327 chr22:18169212 T/G cg19898043 chr22:18121309 BCL2L13 -0.41 -5.28 -0.31 2.63e-7 Myeloid white cell count;Granulocyte count; CESC cis rs17095355 0.579 rs72828224 chr10:111702047 A/G cg00817464 chr10:111662876 XPNPEP1 -0.42 -5.16 -0.3 4.96e-7 Biliary atresia; CESC cis rs11203032 0.831 rs10887932 chr10:90966996 C/G cg16672925 chr10:90967113 CH25H 0.73 7.12 0.4 1.01e-11 Heart failure; CESC cis rs11214589 0.651 rs11214594 chr11:113259332 G/A cg14159747 chr11:113255604 NA 0.33 5.91 0.34 1.04e-8 Neuroticism; CESC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg18758796 chr5:131593413 PDLIM4 0.39 5.25 0.31 3.11e-7 Acylcarnitine levels; CESC cis rs9388451 0.903 rs9388446 chr6:126064920 T/A cg05901451 chr6:126070800 HEY2 -0.62 -8.72 -0.47 3.16e-16 Brugada syndrome; CESC cis rs2011503 0.882 rs1064395 chr19:19361735 C/T cg11584989 chr19:19387371 SF4 0.54 6.53 0.37 3.31e-10 Bipolar disorder; CESC trans rs11992162 0.967 rs11250185 chr8:11833123 G/C cg15556689 chr8:8085844 FLJ10661 0.54 6.25 0.36 1.64e-9 Monocyte count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01062786 chr14:20929651 TMEM55B -0.45 -6.0 -0.35 6.62e-9 Ulcerative colitis; CESC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.62 6.03 0.35 5.53e-9 Cerebrospinal P-tau181p levels; CESC cis rs933688 1.000 rs6865495 chr5:90746424 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.06 13.27 0.63 3.82e-31 Smoking behavior; CESC trans rs4349753 0.663 rs10051221 chr5:144079276 A/G cg22407458 chr6:35109121 TCP11 0.5 6.35 0.36 9.52e-10 Photic sneeze reflex; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10316662 chr8:93156389 NA -0.56 -6.35 -0.36 9.22e-10 Gut microbiome composition (summer); CESC cis rs3761218 1.000 rs3761219 chr20:3776368 T/C cg25011176 chr20:3776985 CDC25B -0.5 -6.4 -0.37 6.92e-10 Bipolar disorder; CESC cis rs11642862 1.000 rs74483355 chr16:30836430 C/T cg02466173 chr16:30829666 NA -0.58 -5.75 -0.33 2.39e-8 Tonsillectomy; CESC cis rs17001868 0.568 rs73167007 chr22:40734241 G/C cg07138101 chr22:40742427 ADSL 0.54 5.18 0.3 4.49e-7 Mammographic density (dense area); CESC cis rs8067354 0.540 rs1051424 chr17:58024324 A/G cg02344993 chr17:57696989 CLTC 0.51 5.24 0.31 3.32e-7 Hemoglobin concentration; CESC cis rs2204008 0.805 rs11180825 chr12:38242916 G/T cg13010199 chr12:38710504 ALG10B 0.51 6.3 0.36 1.24e-9 Bladder cancer; CESC cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7188697 0.848 rs42947 chr16:58579158 A/C cg21335942 chr16:58549945 SETD6 0.45 5.37 0.31 1.75e-7 QT interval; CESC trans rs1681739 0.540 rs10886010 chr10:118546590 C/T cg02989244 chr10:28657270 NA 0.39 6.02 0.35 5.66e-9 Vertical cup-disc ratio; CESC cis rs2963155 0.518 rs72801080 chr5:142751990 T/C cg17617527 chr5:142782415 NR3C1 0.74 5.78 0.33 2.12e-8 Breast cancer; CESC cis rs1707322 1.000 rs10890370 chr1:46389217 C/T cg03146154 chr1:46216737 IPP 0.74 10.22 0.53 6.86e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6121246 0.821 rs6121209 chr20:30311258 G/C cg13852791 chr20:30311386 BCL2L1 0.83 8.72 0.47 3.23e-16 Mean corpuscular hemoglobin; CESC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.25 0.53 5.71e-21 Prudent dietary pattern; CESC cis rs478304 0.817 rs524475 chr11:65518065 T/A cg08755490 chr11:65554678 OVOL1 0.46 6.15 0.35 2.83e-9 Acne (severe); CESC cis rs965469 0.817 rs6037582 chr20:3351696 C/T cg17110299 chr20:3385021 C20orf194 0.39 5.12 0.3 5.87e-7 IFN-related cytopenia; CESC cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg26597838 chr10:835615 NA 1.16 10.98 0.56 2.22e-23 Eosinophil percentage of granulocytes; CESC cis rs2721195 0.614 rs12719778 chr8:145879883 T/C cg26752003 chr8:145688521 CYHR1 -0.4 -5.07 -0.3 7.35e-7 Age at first birth; CESC cis rs3857067 0.806 rs72665608 chr4:95093501 T/C cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.04 -0.49 3.47e-17 QT interval; CESC cis rs12458462 0.892 rs58675823 chr18:77463672 G/A cg11879182 chr18:77439856 CTDP1 0.88 13.89 0.65 2.56e-33 Monocyte count; CESC cis rs854765 0.618 rs8066982 chr17:17851377 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC cis rs7258465 0.965 rs1560118 chr19:18570035 G/A cg25828334 chr19:18545568 ISYNA1 -0.32 -5.16 -0.3 4.8e-7 Breast cancer; CESC cis rs61759167 0.954 rs28594467 chr1:3097051 C/T cg01961086 chr1:3086487 PRDM16 -0.34 -5.08 -0.3 6.97e-7 Motion sickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12699044 chr12:113703999 TPCN1 -0.51 -6.08 -0.35 4.12e-9 Gut microbiome composition (summer); CESC cis rs9303401 0.659 rs34913878 chr17:56897094 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.5 0.61 1.71e-28 Cognitive test performance; CESC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg07395648 chr5:131743802 NA -0.42 -5.52 -0.32 7.91e-8 Breast cancer; CESC cis rs11792861 0.926 rs7870597 chr9:111871864 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.41 5.15 0.3 5.08e-7 Menarche (age at onset); CESC cis rs523522 0.885 rs524735 chr12:121022099 T/C cg27279351 chr12:120934652 DYNLL1 0.7 8.92 0.48 7.88e-17 High light scatter reticulocyte count; CESC cis rs2404602 0.647 rs11631394 chr15:76973209 G/T cg23625390 chr15:77176239 SCAPER -0.47 -6.59 -0.38 2.42e-10 Blood metabolite levels; CESC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs4130590 1.000 rs4130590 chr9:130107964 C/T cg13736810 chr9:130213283 LRSAM1;RPL12 -0.48 -5.88 -0.34 1.22e-8 Bipolar disorder; CESC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg06873352 chr17:61820015 STRADA 0.49 7.24 0.41 4.86e-12 Height; CESC cis rs9902453 0.866 rs4795529 chr17:28443549 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 8.69 0.47 3.72e-16 Coffee consumption (cups per day); CESC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg07952391 chr2:88470173 THNSL2 0.59 5.81 0.34 1.74e-8 Plasma clusterin levels; CESC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.01 8.88 0.48 1.05e-16 Platelet count; CESC cis rs6570726 0.846 rs439035 chr6:145887990 G/C cg23711669 chr6:146136114 FBXO30 0.84 12.72 0.62 3.06e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs6691722 0.503 rs6667695 chr1:24707669 G/A cg18323236 chr1:24743029 NIPAL3 0.37 5.47 0.32 1.02e-7 Response to interferon beta in multiple sclerosis; CESC trans rs7246657 0.943 rs10417844 chr19:37837587 C/T cg24637308 chr11:6592297 DNHD1 0.53 6.17 0.35 2.55e-9 Coronary artery calcification; CESC cis rs950776 0.616 rs6495307 chr15:78890321 C/T cg06917634 chr15:78832804 PSMA4 0.56 7.31 0.41 3.14e-12 Sudden cardiac arrest; CESC cis rs6831352 0.918 rs17218108 chr4:100055755 T/C cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg00149659 chr3:10157352 C3orf10 0.73 8.89 0.48 9.97e-17 Alzheimer's disease; CESC cis rs7772486 0.875 rs7761033 chr6:146356106 C/T cg23711669 chr6:146136114 FBXO30 0.85 12.46 0.61 2.27e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs2439831 1.000 rs471229 chr15:43733994 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.52 0.54 7.36e-22 Lung cancer in ever smokers; CESC cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs765787 0.530 rs12442533 chr15:45529631 G/C cg24006582 chr15:45444508 DUOX1 0.57 6.94 0.39 3.04e-11 Uric acid levels; CESC cis rs6688613 0.579 rs4657609 chr1:166839174 G/A ch.1.3259774R chr1:166827647 TADA1 0.56 5.38 0.31 1.66e-7 Refractive astigmatism; CESC trans rs877282 1.000 rs12773872 chr10:771939 T/C cg22713356 chr15:30763199 NA 1.26 12.75 0.62 2.39e-29 Uric acid levels; CESC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.76 9.6 0.51 6.23e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs6582630 0.594 rs7308707 chr12:38450428 G/C cg26384229 chr12:38710491 ALG10B -0.44 -5.83 -0.34 1.62e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs2066819 1.000 rs116849218 chr12:56683975 C/T cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs2281558 0.876 rs6107025 chr20:25279880 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.62 8.34 0.46 4.18e-15 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs10504229 0.636 rs114725691 chr8:58054292 C/T cg02725872 chr8:58115012 NA -0.33 -5.06 -0.3 7.77e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16365729 chr1:244998894 FAM36A 0.56 6.83 0.39 5.89e-11 Gut microbiome composition (summer); CESC cis rs7085104 0.700 rs7096183 chr10:104609466 T/C cg04362960 chr10:104952993 NT5C2 0.52 6.74 0.38 1.01e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg24675658 chr1:53192096 ZYG11B 0.54 7.53 0.42 7.89e-13 Monocyte count; CESC cis rs7044106 0.791 rs10760116 chr9:123494681 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.74 10.98 0.56 2.31e-23 Hip circumference adjusted for BMI; CESC trans rs2727020 0.576 rs1814175 chr11:49559172 T/C cg15704280 chr7:45808275 SEPT13 -0.94 -16.04 -0.7 6.25e-41 Coronary artery disease; CESC cis rs1045714 0.943 rs56063345 chr7:2653504 C/G cg20813462 chr7:2646259 IQCE 0.74 6.04 0.35 5.3e-9 Urate levels in lean individuals; CESC cis rs7833986 0.501 rs72653921 chr8:56897157 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.16 0.4 8.04e-12 Height; CESC cis rs10779751 0.960 rs4845860 chr1:11324193 A/G cg08854313 chr1:11322531 MTOR 0.82 11.19 0.57 4.69e-24 Body mass index; CESC cis rs2439831 0.850 rs7169322 chr15:44131014 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.6 0.33 5.26e-8 Lung cancer in ever smokers; CESC cis rs17253792 0.822 rs17747083 chr14:56110594 T/C cg01858014 chr14:56050164 KTN1 -0.85 -7.03 -0.4 1.73e-11 Putamen volume; CESC cis rs4722585 0.533 rs12334205 chr7:26202490 G/A cg07876897 chr7:26191696 NFE2L3 0.42 5.38 0.31 1.68e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); CESC cis rs7264396 1.000 rs224415 chr20:34135629 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -6.86 -0.39 4.94e-11 Total cholesterol levels; CESC cis rs992157 0.798 rs7557709 chr2:219167529 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.16 0.49 1.46e-17 Colorectal cancer; CESC cis rs11098499 0.779 rs10016060 chr4:120298412 A/G cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs6752107 1.000 rs6738490 chr2:234161583 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.92 0.39 3.4e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg04414720 chr1:150670196 GOLPH3L 0.48 6.49 0.37 4.12e-10 Melanoma; CESC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.77 10.94 0.56 3.14e-23 Prudent dietary pattern; CESC cis rs10791097 0.690 rs12286234 chr11:130730528 T/C cg12179176 chr11:130786555 SNX19 0.56 8.14 0.45 1.57e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs763014 0.966 rs7198877 chr16:661439 A/G cg00802000 chr16:706648 WDR90 -0.41 -6.33 -0.36 1.04e-9 Height; CESC cis rs7267979 1.000 rs2482943 chr20:25380593 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -15.87 -0.7 2.51e-40 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05166819 chr7:72936456 BAZ1B 0.58 6.32 0.36 1.08e-9 Gut microbiome composition (summer); CESC cis rs752010 0.655 rs10890145 chr1:42086290 A/G cg06885757 chr1:42089581 HIVEP3 0.51 8.84 0.48 1.39e-16 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08679808 chr17:79886116 LOC92659;MAFG 0.63 7.37 0.41 2.21e-12 Gut microbiome composition (summer); CESC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg17143192 chr8:8559678 CLDN23 0.73 8.68 0.47 4.03e-16 Obesity-related traits; CESC cis rs6061231 1.000 rs11908473 chr20:60957770 C/G cg06197360 chr20:60970103 CABLES2 -0.4 -5.03 -0.3 8.87e-7 Colorectal cancer; CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg07167872 chr1:205819463 PM20D1 0.86 15.38 0.69 1.36e-38 Menarche (age at onset); CESC cis rs4595586 0.679 rs7312898 chr12:39346833 T/C cg26384229 chr12:38710491 ALG10B 0.42 6.07 0.35 4.31e-9 Morning vs. evening chronotype; CESC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg05457628 chr5:178986728 RUFY1 0.45 6.47 0.37 4.74e-10 Lung cancer; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg02895995 chr19:7554069 PEX11G -0.47 -6.58 -0.37 2.49e-10 Height; CESC cis rs503341 0.756 rs626333 chr11:63591861 C/T cg04362095 chr11:63592001 C11orf84 -0.56 -8.25 -0.45 7.67e-15 Pulse pressure; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg03946899 chr15:98503444 ARRDC4 0.46 6.05 0.35 4.82e-9 Thyroid stimulating hormone; CESC cis rs10838687 0.736 rs12574081 chr11:47286414 G/A cg25783544 chr11:47291846 MADD 0.59 5.78 0.33 2.05e-8 Proinsulin levels; CESC cis rs6502050 0.835 rs4789668 chr17:80161990 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.15 -0.3 4.98e-7 Life satisfaction; CESC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg08968635 chr6:28129556 ZNF389 0.42 5.72 0.33 2.82e-8 Parkinson's disease; CESC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs11711311 1.000 rs9288984 chr3:113525956 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.55 7.19 0.4 6.5e-12 IgG glycosylation; CESC cis rs8072100 0.607 rs9894594 chr17:45461383 A/G cg08085267 chr17:45401833 C17orf57 -0.51 -6.49 -0.37 4.12e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6991838 0.584 rs35790435 chr8:66502523 G/A cg13398993 chr8:66546079 ARMC1 -0.47 -5.65 -0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs9549367 0.774 rs2287246 chr13:113889127 A/G cg00898013 chr13:113819073 PROZ -0.52 -7.2 -0.4 6.09e-12 Platelet distribution width; CESC cis rs79976124 0.837 rs12194087 chr6:66644399 T/A cg07460842 chr6:66804631 NA 0.69 8.07 0.44 2.5e-14 Type 2 diabetes; CESC cis rs10089 1.000 rs2409109 chr5:127461471 C/T cg19767477 chr5:127420684 SLC12A2 -0.4 -5.32 -0.31 2.18e-7 Ileal carcinoids; CESC cis rs950776 0.684 rs692780 chr15:78876505 C/G cg06917634 chr15:78832804 PSMA4 -0.54 -6.65 -0.38 1.62e-10 Sudden cardiac arrest; CESC cis rs66731853 0.557 rs477190 chr1:20898514 C/A cg04087271 chr1:20915334 CDA -0.39 -5.47 -0.32 1.06e-7 Mean corpuscular volume; CESC cis rs7647973 0.626 rs2329021 chr3:49679072 G/A cg13072238 chr3:49761600 GMPPB -0.45 -5.47 -0.32 1.04e-7 Menarche (age at onset); CESC cis rs12618769 0.652 rs4851145 chr2:99222916 A/G cg10123293 chr2:99228465 UNC50 -0.41 -5.47 -0.32 1.02e-7 Bipolar disorder; CESC cis rs2658782 0.789 rs2658776 chr11:93147927 A/G cg15737290 chr11:93063684 CCDC67 0.49 5.87 0.34 1.27e-8 Pulmonary function decline; CESC cis rs727563 0.594 rs132807 chr22:42071584 T/C cg03806693 chr22:41940476 POLR3H 1.09 12.68 0.61 4.09e-29 Crohn's disease;Inflammatory bowel disease; CESC cis rs447 1.000 rs3801655 chr7:83753335 C/G cg22846510 chr7:83753280 SEMA3A -0.45 -5.73 -0.33 2.66e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs4596713 0.538 rs11145484 chr9:71769857 G/C cg16512924 chr15:28394682 HERC2 0.48 6.09 0.35 3.97e-9 Headache; CESC cis rs2952156 0.920 rs2934956 chr17:37830447 T/A cg07936489 chr17:37558343 FBXL20 -0.59 -7.57 -0.42 6.11e-13 Asthma; CESC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg10074409 chr1:209979377 IRF6 0.36 5.79 0.34 1.94e-8 Cleft lip with or without cleft palate; CESC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg06877462 chr1:205807181 PM20D1 0.4 5.88 0.34 1.21e-8 Menarche (age at onset); CESC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg08736216 chr1:53307985 ZYG11A -0.34 -5.79 -0.34 1.97e-8 Monocyte count; CESC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg18305652 chr10:134549665 INPP5A -0.49 -7.28 -0.41 3.77e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9399137 0.507 rs6923512 chr6:135335268 A/G cg22676075 chr6:135203613 NA -0.53 -6.93 -0.39 3.21e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs6088580 0.524 rs6088569 chr20:33268199 G/A cg08999081 chr20:33150536 PIGU -0.45 -6.29 -0.36 1.33e-9 Glomerular filtration rate (creatinine); CESC cis rs11252926 0.673 rs7096559 chr10:499188 C/T cg16386425 chr10:429943 DIP2C -0.45 -5.68 -0.33 3.48e-8 Psychosis in Alzheimer's disease; CESC cis rs748404 0.660 rs689767 chr15:43722077 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.55 0.42 7.19e-13 Lung cancer; CESC cis rs6540556 0.682 rs667681 chr1:209914449 A/G cg23920097 chr1:209922102 NA 0.39 5.1 0.3 6.53e-7 Red blood cell count; CESC cis rs1006703 0.544 rs35586043 chr17:3832981 A/G cg06463185 chr17:3833770 ATP2A3 -0.54 -5.89 -0.34 1.18e-8 Glucose homeostasis traits; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13369624 chr13:21714458 SAP18 -0.51 -6.4 -0.37 7e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg17108838 chr11:10327138 ADM -0.49 -7.08 -0.4 1.29e-11 Prostate cancer (SNP x SNP interaction); CESC trans rs2727020 0.617 rs1917311 chr11:49422665 C/T cg03929089 chr4:120376271 NA -0.82 -12.66 -0.61 4.91e-29 Coronary artery disease; CESC cis rs11792861 0.816 rs28361111 chr9:111761012 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.53 6.83 0.39 5.63e-11 Menarche (age at onset); CESC cis rs7267979 0.932 rs6037125 chr20:25463382 G/A cg08601574 chr20:25228251 PYGB 0.36 5.34 0.31 2.05e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7953508 0.506 rs12425869 chr12:93961353 A/G cg18151635 chr12:93972918 NA -0.4 -5.32 -0.31 2.18e-7 Pubertal anthropometrics; CESC cis rs12477438 0.798 rs2084987 chr2:99587885 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs4722166 0.630 rs1581497 chr7:22779503 C/A cg05472934 chr7:22766657 IL6 0.87 10.94 0.56 3.06e-23 Lung cancer; CESC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg18252515 chr7:66147081 NA -0.47 -6.41 -0.37 6.57e-10 Aortic root size; CESC trans rs9467711 0.659 rs13195509 chr6:26463660 C/T cg06606381 chr12:133084897 FBRSL1 -1.0 -8.39 -0.46 2.9e-15 Autism spectrum disorder or schizophrenia; CESC cis rs7605827 0.930 rs6760888 chr2:15537863 T/C cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs4908768 0.501 rs4908760 chr1:8526142 G/A cg00120948 chr1:8484417 RERE -0.34 -5.28 -0.31 2.7e-7 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CESC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg23283495 chr1:209979779 IRF6 0.53 6.34 0.36 9.65e-10 Cleft lip with or without cleft palate; CESC cis rs6504663 0.558 rs7627 chr17:48552154 G/C cg03611598 chr17:48586076 MYCBPAP 0.52 6.06 0.35 4.6e-9 Visceral fat; CESC cis rs4141404 0.582 rs5753630 chr22:31861950 A/G cg13145458 chr22:31556086 RNF185 -0.42 -5.09 -0.3 6.73e-7 Paclitaxel-induced neuropathy; CESC cis rs9611565 0.694 rs4822032 chr22:41925535 T/C cg17376030 chr22:41985996 PMM1 0.42 5.05 0.3 8.22e-7 Vitiligo; CESC cis rs9926296 0.712 rs2437957 chr16:89715648 G/A cg27121462 chr16:89883253 FANCA -0.48 -5.66 -0.33 3.97e-8 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10756274 chr17:77813223 CBX4 0.54 6.13 0.35 3.15e-9 Gut microbiome composition (summer); CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg05215748 chr17:6898738 ALOX12 -0.33 -6.64 -0.38 1.77e-10 Tonsillectomy; CESC cis rs72949976 1.000 rs62186569 chr2:214034151 C/T cg08319019 chr2:214017104 IKZF2 -0.44 -5.49 -0.32 9.55e-8 Lung cancer;Squamous cell lung carcinoma; CESC cis rs7949030 0.588 rs2512563 chr11:62311249 C/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.4 -0.31 1.52e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9362426 0.895 rs242292 chr6:88078074 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.48 5.92 0.34 9.87e-9 Depressive episodes in bipolar disorder; CESC cis rs7107174 1.000 rs11237469 chr11:78072875 A/T cg02023728 chr11:77925099 USP35 0.47 6.18 0.35 2.45e-9 Testicular germ cell tumor; CESC cis rs7267979 0.649 rs2500406 chr20:25401862 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -11.09 -0.56 9.89e-24 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18577128 chr1:46269120 MAST2 0.62 6.99 0.39 2.2e-11 Gut microbiome composition (summer); CESC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg03806693 chr22:41940476 POLR3H 1.21 14.0 0.65 1.02e-33 Vitiligo; CESC cis rs7071206 1.000 rs7071206 chr10:79401316 C/T cg23888215 chr10:79422304 NA 0.54 6.26 0.36 1.54e-9 Bone mineral density; CESC cis rs7177699 0.557 rs7403593 chr15:79111962 A/G cg04896959 chr15:78267971 NA 0.32 5.04 0.3 8.54e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs17253792 0.822 rs80174205 chr14:56058694 T/C cg01858014 chr14:56050164 KTN1 -0.96 -7.13 -0.4 9.72e-12 Putamen volume; CESC trans rs1945213 0.694 rs7122627 chr11:55862565 A/G cg15704280 chr7:45808275 SEPT13 0.76 7.34 0.41 2.57e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.830 rs991168 chr4:98928293 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs12142240 0.698 rs55971480 chr1:46823206 G/T cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg18876405 chr7:65276391 NA -0.52 -7.17 -0.4 7.39e-12 Aortic root size; CESC cis rs71191701 1.000 rs71191701 chr9:139322257 G/C cg14169450 chr9:139327907 INPP5E 0.43 5.32 0.31 2.17e-7 Myeloid white cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; CESC trans rs35110281 0.748 rs1584918 chr21:45042419 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 6.9 0.39 3.75e-11 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04179819 chr10:7860513 TAF3 0.52 6.16 0.35 2.7e-9 Gut microbiome composition (summer); CESC trans rs60843830 1.000 rs55753056 chr2:243929 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 8.07 0.44 2.53e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs858239 0.508 rs7805085 chr7:23190243 C/T cg23682824 chr7:23144976 KLHL7 0.46 5.85 0.34 1.45e-8 Cerebrospinal fluid biomarker levels; CESC cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg20503657 chr10:835505 NA 0.72 6.47 0.37 4.64e-10 Eosinophil percentage of granulocytes; CESC cis rs7927771 0.832 rs896816 chr11:47394338 T/C cg20307385 chr11:47447363 PSMC3 0.59 7.02 0.4 1.88e-11 Subjective well-being; CESC cis rs9902453 0.679 rs2054847 chr17:28532013 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 7.05 0.4 1.59e-11 Coffee consumption (cups per day); CESC cis rs2991971 0.810 rs998199 chr1:45912898 A/C cg05343316 chr1:45956843 TESK2 0.59 8.4 0.46 2.68e-15 High light scatter reticulocyte count; CESC cis rs2731664 0.765 rs2630766 chr5:176874941 A/C cg23176889 chr5:176863531 GRK6 -0.64 -11.24 -0.57 3.19e-24 Intelligence (multi-trait analysis); CESC cis rs17826219 0.706 rs8071236 chr17:29100002 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Body mass index; CESC cis rs6460942 0.630 rs17671056 chr7:12390961 C/G cg20607287 chr7:12443886 VWDE -0.62 -6.71 -0.38 1.21e-10 Coronary artery disease; CESC cis rs12200560 0.505 rs172425 chr6:97075299 A/T cg06623918 chr6:96969491 KIAA0776 0.5 6.49 0.37 4.13e-10 Coronary heart disease; CESC cis rs1401999 0.510 rs17817736 chr3:183720313 A/T cg01324343 chr3:183735012 ABCC5 -0.36 -6.13 -0.35 3.18e-9 Anterior chamber depth; CESC cis rs9788682 0.747 rs2656071 chr15:78745343 A/T cg24631222 chr15:78858424 CHRNA5 -0.62 -7.58 -0.42 5.91e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs2845885 0.744 rs3802932 chr11:63988045 G/A cg24431193 chr11:63883947 FLRT1;MACROD1 0.63 5.83 0.34 1.59e-8 Body mass index; CESC cis rs4237845 0.844 rs7306124 chr12:58303349 A/T cg02175503 chr12:58329896 NA 0.74 10.46 0.54 1.16e-21 Intelligence (multi-trait analysis); CESC cis rs6545883 0.929 rs778155 chr2:61647901 A/G cg15711740 chr2:61764176 XPO1 0.4 5.13 0.3 5.47e-7 Tuberculosis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg05654049 chr3:23852499 UBE2E1 0.49 6.59 0.38 2.38e-10 Height; CESC cis rs6011002 0.938 rs117314802 chr20:62301849 A/G cg15212369 chr20:62274085 STMN3 -0.57 -5.16 -0.3 4.91e-7 Dental caries; CESC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 7.95 0.44 5.36e-14 Platelet count; CESC cis rs72781680 1.000 rs12623496 chr2:24181583 C/T cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs8017423 0.934 rs2401874 chr14:90682467 C/T cg14092571 chr14:90743983 NA -0.57 -8.61 -0.47 6.77e-16 Mortality in heart failure; CESC cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg05283184 chr6:79620031 NA -0.44 -6.64 -0.38 1.74e-10 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22273042 chr8:81083829 TPD52 -0.45 -6.44 -0.37 5.63e-10 Fibrinogen levels; CESC cis rs2290159 0.800 rs6792773 chr3:12668726 C/T cg23032965 chr3:12705835 RAF1 0.54 5.71 0.33 3.02e-8 Cholesterol, total; CESC cis rs6540559 0.543 rs650728 chr1:210433351 C/T cg22029157 chr1:209979665 IRF6 0.52 5.9 0.34 1.13e-8 Cleft lip with or without cleft palate; CESC cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg06970220 chr1:156163860 SLC25A44 0.39 5.18 0.3 4.32e-7 Testicular germ cell tumor; CESC cis rs10851478 0.872 rs12906972 chr15:49858901 T/C cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs12579753 0.871 rs10862363 chr12:82201254 T/A cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg00750074 chr16:89608354 SPG7 -0.44 -6.41 -0.37 6.71e-10 Multiple myeloma (IgH translocation); CESC trans rs11252926 0.624 rs7085214 chr10:468133 A/G cg00953403 chr17:74099816 EXOC7 0.54 6.96 0.39 2.67e-11 Psychosis in Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16712549 chr7:39773156 LOC349114 -0.46 -6.07 -0.35 4.44e-9 Fibrinogen levels; CESC cis rs965469 0.724 rs6051818 chr20:3362033 T/C cg25506879 chr20:3388711 C20orf194 -0.49 -5.28 -0.31 2.63e-7 IFN-related cytopenia; CESC cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 7.26 0.41 4.4e-12 Personality dimensions; CESC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg13206674 chr6:150067644 NUP43 0.42 5.89 0.34 1.19e-8 Lung cancer; CESC trans rs11039798 1.000 rs10769370 chr11:48515430 A/G cg15704280 chr7:45808275 SEPT13 0.69 6.14 0.35 3.07e-9 Axial length; CESC cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg16928487 chr17:17741425 SREBF1 0.53 8.68 0.47 4.22e-16 Total body bone mineral density; CESC trans rs17685 0.712 rs1859792 chr7:75789264 T/C cg19862616 chr7:65841803 NCRNA00174 0.79 10.97 0.56 2.48e-23 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2302190 0.882 rs12939703 chr17:56611090 G/C cg25885038 chr17:56607967 SEPT4 -0.41 -5.61 -0.33 5.13e-8 Vitamin D levels; CESC cis rs6088580 0.634 rs1205338 chr20:32925625 C/G cg06115741 chr20:33292138 TP53INP2 -0.44 -5.54 -0.32 7.13e-8 Glomerular filtration rate (creatinine); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg06657462 chr10:94608040 EXOC6 0.52 6.76 0.38 8.91e-11 Thyroid stimulating hormone; CESC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.05 10.33 0.54 2.97e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.6e-24 Menopause (age at onset); CESC cis rs7223966 1.000 rs7222060 chr17:61868279 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.74 0.38 9.84e-11 Hip circumference adjusted for BMI;Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07348339 chr7:2609259 IQCE -0.55 -6.2 -0.36 2.13e-9 Gut microbiome composition (summer); CESC cis rs6598955 0.671 rs7417505 chr1:26575523 A/G cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg22029157 chr1:209979665 IRF6 0.66 8.08 0.44 2.34e-14 Cleft lip with or without cleft palate; CESC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg02951883 chr7:2050386 MAD1L1 0.56 7.77 0.43 1.73e-13 Bipolar disorder and schizophrenia; CESC cis rs9987353 0.544 rs2929469 chr8:9062656 T/G cg06636001 chr8:8085503 FLJ10661 0.52 6.29 0.36 1.34e-9 Recombination measurement; CESC trans rs6054906 0.710 rs6117744 chr20:7265038 A/C cg19245296 chr20:10015646 ANKRD5 0.45 6.3 0.36 1.23e-9 Response to amphetamines; CESC cis rs35849525 0.814 rs35491931 chr3:49993462 T/A cg03060546 chr3:49711283 APEH -0.47 -5.43 -0.32 1.3e-7 Intelligence (multi-trait analysis); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg27391037 chr22:18560705 PEX26 0.46 6.18 0.35 2.39e-9 Thyroid stimulating hormone; CESC cis rs17431357 0.867 rs117054838 chr12:120993600 C/G cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg26335602 chr6:28129616 ZNF389 0.53 6.75 0.38 9.35e-11 Depression; CESC cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg05340658 chr4:99064831 C4orf37 0.76 11.15 0.57 6.22e-24 Colonoscopy-negative controls vs population controls; CESC cis rs7520050 0.966 rs7556615 chr1:46461369 G/A cg24296786 chr1:45957014 TESK2 0.45 5.65 0.33 4.17e-8 Red blood cell count;Reticulocyte count; CESC cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg05340658 chr4:99064831 C4orf37 0.8 12.49 0.61 1.91e-28 Colonoscopy-negative controls vs population controls; CESC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg26343298 chr8:95960752 TP53INP1 0.35 5.77 0.33 2.22e-8 Type 2 diabetes; CESC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg22907277 chr7:1156413 C7orf50 0.44 6.33 0.36 1.02e-9 Longevity;Endometriosis; CESC cis rs2742234 0.541 rs10899778 chr10:43718509 G/C cg07801480 chr10:43725741 RASGEF1A -0.4 -5.24 -0.31 3.22e-7 Hirschsprung disease; CESC cis rs72901758 0.768 rs55782477 chr17:76250703 G/C cg23302638 chr17:76210176 BIRC5 0.48 5.22 0.31 3.6e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg05368731 chr17:41323189 NBR1 0.76 10.6 0.55 4.15e-22 Menopause (age at onset); CESC cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg19626725 chr5:178986131 RUFY1 0.34 5.2 0.3 4.06e-7 Lung cancer; CESC cis rs3857536 0.730 rs7761295 chr6:66932532 G/A cg07460842 chr6:66804631 NA -0.42 -5.36 -0.31 1.8e-7 Blood trace element (Cu levels); CESC cis rs911555 0.539 rs4374097 chr14:104072766 A/C cg12935359 chr14:103987150 CKB -0.5 -7.39 -0.41 1.9e-12 Intelligence (multi-trait analysis); CESC trans rs208520 0.690 rs207740 chr6:66764132 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.45 0.61 2.48e-28 Exhaled nitric oxide output; CESC cis rs36096196 0.891 rs12082516 chr1:2251160 C/T cg00093522 chr1:2252019 NA -0.43 -6.2 -0.36 2.16e-9 Coronary artery disease; CESC trans rs1814175 0.645 rs7123448 chr11:49764865 T/G cg03929089 chr4:120376271 NA -0.89 -13.73 -0.64 8.96e-33 Height; CESC cis rs10982213 0.830 rs7861409 chr9:117181190 A/G cg00969271 chr9:117093052 ORM2 0.4 5.61 0.33 5.12e-8 Interleukin-6 levels; CESC cis rs798766 1.000 rs798741 chr4:1712413 A/G cg10756475 chr4:1757242 NA 0.38 5.24 0.31 3.35e-7 Bladder cancer;Urinary bladder cancer; CESC trans rs9388451 0.868 rs1268083 chr6:126049040 T/C cg05039488 chr6:79577232 IRAK1BP1 0.55 7.25 0.41 4.53e-12 Brugada syndrome; CESC cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg23711669 chr6:146136114 FBXO30 -1.0 -15.54 -0.69 3.89e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs4803455 0.565 rs11670143 chr19:41864971 A/G cg09537434 chr19:41945824 ATP5SL -0.71 -9.67 -0.51 3.97e-19 Migraine;Coronary artery disease; CESC cis rs7618501 0.521 rs2352984 chr3:49948728 T/C cg24110177 chr3:50126178 RBM5 -0.55 -7.72 -0.43 2.39e-13 Intelligence (multi-trait analysis); CESC cis rs7264396 0.635 rs6060719 chr20:34546013 A/C cg17201900 chr20:34330562 RBM39 0.52 5.44 0.32 1.21e-7 Total cholesterol levels; CESC cis rs561341 1.000 rs484175 chr17:30309041 G/A cg23018236 chr17:30244563 NA -0.52 -5.1 -0.3 6.39e-7 Hip circumference adjusted for BMI; CESC trans rs338389 0.934 rs338403 chr15:68251687 T/C cg10595952 chr5:2097052 NA -0.36 -6.03 -0.35 5.34e-9 Survival in rectal cancer; CESC trans rs1249910 0.845 rs820544 chr3:112406563 A/G cg23605328 chr1:201951606 RNPEP -0.48 -6.27 -0.36 1.44e-9 Diabetic kidney disease; CESC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg18876405 chr7:65276391 NA 0.47 6.21 0.36 1.98e-9 Aortic root size; CESC cis rs2832191 0.740 rs2832175 chr21:30475606 A/G cg08807101 chr21:30365312 RNF160 -0.93 -14.29 -0.66 9.64e-35 Dental caries; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01882179 chr12:93964653 SOCS2 -0.4 -6.08 -0.35 4.11e-9 Gambling; CESC cis rs5769765 0.817 rs9616212 chr22:50317687 G/A cg02269571 chr22:50332266 NA -0.57 -6.6 -0.38 2.28e-10 Schizophrenia; CESC cis rs11190604 1.000 rs10883509 chr10:102296461 C/T cg07080220 chr10:102295463 HIF1AN 0.7 6.5 0.37 4.02e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs62064224 0.748 rs72813015 chr17:30693331 T/C cg25809561 chr17:30822961 MYO1D 0.58 8.2 0.45 1.04e-14 Schizophrenia; CESC cis rs10899021 0.790 rs12288525 chr11:74332589 T/A cg25880958 chr11:74394337 NA -0.65 -6.92 -0.39 3.44e-11 Response to metformin (IC50); CESC cis rs6963495 0.546 rs2697020 chr7:105150046 C/T cg19920283 chr7:105172520 RINT1 0.53 6.19 0.36 2.3e-9 Bipolar disorder (body mass index interaction); CESC cis rs8141529 0.719 rs9625619 chr22:29272328 T/A cg02153584 chr22:29168773 CCDC117 0.6 7.84 0.43 1.13e-13 Lymphocyte counts; CESC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.56 0.58 2.62e-25 Platelet count; CESC cis rs4242434 0.892 rs71513892 chr8:22456517 C/G cg03733263 chr8:22462867 KIAA1967 0.97 15.09 0.68 1.51e-37 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg22823121 chr1:150693482 HORMAD1 0.37 5.26 0.31 3.01e-7 Melanoma; CESC trans rs801193 0.967 rs2707841 chr7:66157020 A/G cg26939375 chr7:64535504 NA 0.64 8.67 0.47 4.39e-16 Aortic root size; CESC cis rs11785693 0.862 rs17435605 chr8:4987302 A/G cg26367366 chr8:4980734 NA 0.73 7.3 0.41 3.26e-12 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs60843830 1.000 rs55753056 chr2:243929 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.32 0.54 3.23e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg08847533 chr14:75593920 NEK9 -0.99 -17.91 -0.74 1.46e-47 Height; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg22834172 chr17:37774349 NA -0.49 -7.2 -0.4 6.11e-12 Vertical cup-disc ratio; CESC cis rs2228479 0.717 rs1007932 chr16:89838541 C/T cg27121462 chr16:89883253 FANCA 0.63 5.11 0.3 6.21e-7 Skin colour saturation; CESC cis rs2050392 1.000 rs2489864 chr10:30693744 C/G cg18806716 chr10:30721971 MAP3K8 -0.4 -5.76 -0.33 2.29e-8 Inflammatory bowel disease; CESC cis rs3008870 0.755 rs10749766 chr1:67376921 A/G cg02640540 chr1:67518911 SLC35D1 0.44 5.26 0.31 2.94e-7 Lymphocyte percentage of white cells; CESC cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg25174290 chr11:3078921 CARS -0.56 -7.51 -0.42 9.23e-13 Longevity; CESC cis rs9467711 0.606 rs72841536 chr6:26378288 T/A cg14345882 chr6:26364793 BTN3A2 0.64 6.38 0.36 7.8e-10 Autism spectrum disorder or schizophrenia; CESC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.81 0.39 6.37e-11 Bipolar disorder; CESC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg09877947 chr5:131593287 PDLIM4 -0.51 -6.81 -0.39 6.7e-11 Acylcarnitine levels; CESC trans rs116095464 0.558 rs7731089 chr5:290422 A/C cg00938859 chr5:1591904 SDHAP3 0.65 7.03 0.4 1.73e-11 Breast cancer; CESC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg13393036 chr8:95962371 TP53INP1 -0.45 -9.35 -0.5 3.79e-18 Type 2 diabetes; CESC cis rs763121 1.000 rs763121 chr22:38879940 C/T cg06022373 chr22:39101656 GTPBP1 -0.61 -8.53 -0.46 1.13e-15 Menopause (age at onset); CESC cis rs6547741 0.935 rs6761095 chr2:27778010 G/T cg21248554 chr2:27665150 KRTCAP3 0.26 5.38 0.31 1.62e-7 Oral cavity cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18550498 chr11:1008985 AP2A2 -0.65 -7.62 -0.42 4.41e-13 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08496016 chr9:99181722 ZNF367 -0.41 -6.16 -0.35 2.7e-9 Gambling; CESC cis rs16937 0.662 rs12137294 chr1:205182872 A/C cg21643547 chr1:205240462 TMCC2 -0.33 -5.4 -0.31 1.48e-7 Schizophrenia; CESC cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg20090143 chr19:45452003 APOC2 0.36 6.25 0.36 1.61e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs854765 0.583 rs11869536 chr17:17826528 T/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.28 0.41 3.9e-12 Total body bone mineral density; CESC cis rs3806843 0.735 rs801188 chr5:140066916 G/T cg16179182 chr5:140090404 VTRNA1-1 0.42 5.48 0.32 1e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9303280 0.773 rs12949100 chr17:38057189 G/A cg20243544 chr17:37824526 PNMT 0.53 6.86 0.39 4.75e-11 Self-reported allergy; CESC cis rs6088580 0.634 rs6059887 chr20:33101102 C/G cg24642439 chr20:33292090 TP53INP2 0.51 6.62 0.38 1.99e-10 Glomerular filtration rate (creatinine); CESC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg04944784 chr2:26401820 FAM59B -0.61 -7.05 -0.4 1.6e-11 Gut microbiome composition (summer); CESC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg17541715 chr7:1216824 NA -0.38 -5.11 -0.3 6.04e-7 Longevity;Endometriosis; CESC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg17143192 chr8:8559678 CLDN23 0.73 8.68 0.47 4.03e-16 Obesity-related traits; CESC cis rs34638657 0.833 rs7200628 chr16:82200747 C/T cg09439754 chr16:82129088 HSD17B2 -0.36 -5.74 -0.33 2.52e-8 Lung adenocarcinoma; CESC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg24531977 chr5:56204891 C5orf35 -0.85 -10.98 -0.56 2.27e-23 Initial pursuit acceleration; CESC cis rs7666738 0.830 rs4441757 chr4:98927059 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs9303280 0.936 rs907091 chr17:37921742 A/G cg20243544 chr17:37824526 PNMT 0.55 7.53 0.42 7.94e-13 Self-reported allergy; CESC cis rs7666738 0.830 rs13147768 chr4:98833675 A/T cg17366294 chr4:99064904 C4orf37 0.54 7.42 0.41 1.61e-12 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 1.000 rs11039255 chr11:47495746 G/T cg20307385 chr11:47447363 PSMC3 -0.55 -6.53 -0.37 3.35e-10 Subjective well-being; CESC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg19346786 chr7:2764209 NA -0.46 -6.75 -0.38 9.28e-11 Height; CESC cis rs2011503 1.000 rs11669558 chr19:19655670 C/T cg11584989 chr19:19387371 SF4 0.57 6.34 0.36 9.88e-10 Bipolar disorder; CESC cis rs9910055 0.512 rs7209801 chr17:42323376 G/A cg08499158 chr17:42289980 UBTF -0.49 -6.01 -0.35 6.19e-9 Total body bone mineral density; CESC cis rs10876993 1.000 rs10876993 chr12:58062667 C/T cg18357645 chr12:58087776 OS9 0.63 10.16 0.53 1.09e-20 Celiac disease or Rheumatoid arthritis; CESC cis rs3812831 0.599 rs428637 chr13:114927139 T/G cg08824895 chr13:115047677 UPF3A 0.43 5.51 0.32 8.54e-8 Schizophrenia; CESC cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg06713675 chr4:122721982 EXOSC9 -0.45 -6.38 -0.36 7.86e-10 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23939166 chr14:55032812 NA -0.64 -7.64 -0.42 3.97e-13 Gut microbiome composition (summer); CESC cis rs6901004 0.935 rs1150078 chr6:111560301 C/T cg15721981 chr6:111408429 SLC16A10 0.37 5.4 0.32 1.45e-7 Blood metabolite levels; CESC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg24549020 chr5:56110836 MAP3K1 0.68 7.76 0.43 1.85e-13 Initial pursuit acceleration; CESC cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg20476274 chr7:133979776 SLC35B4 0.67 9.8 0.52 1.53e-19 Mean platelet volume; CESC cis rs4862750 0.872 rs13101380 chr4:187894744 G/A cg06074448 chr4:187884817 NA -0.47 -7.25 -0.41 4.57e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg10494973 chr17:80897199 TBCD 0.5 5.64 0.33 4.35e-8 Breast cancer; CESC cis rs1348850 0.757 rs4893969 chr2:178478476 T/A cg23306229 chr2:178417860 TTC30B 0.53 6.66 0.38 1.59e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11098499 0.909 rs10017335 chr4:120381523 C/G cg09307838 chr4:120376055 NA -0.85 -11.56 -0.58 2.63e-25 Corneal astigmatism; CESC cis rs225245 0.817 rs225273 chr17:33970935 A/T cg05299278 chr17:33885742 SLFN14 0.36 5.17 0.3 4.71e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs4268898 0.662 rs9917355 chr2:24433400 C/T cg06627628 chr2:24431161 ITSN2 -1.02 -11.2 -0.57 4.2e-24 Asthma; CESC cis rs4909189 1.000 rs4909189 chr7:158136986 A/T cg24154853 chr7:158122151 PTPRN2 -0.39 -5.28 -0.31 2.67e-7 Response to amphetamines; CESC cis rs861020 0.563 rs12046618 chr1:210043135 C/T cg05527609 chr1:210001259 C1orf107 0.97 10.7 0.55 1.97e-22 Orofacial clefts; CESC cis rs3749237 0.595 rs4855877 chr3:49448527 T/C cg07636037 chr3:49044803 WDR6 0.62 9.04 0.49 3.35e-17 Resting heart rate; CESC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg04287289 chr16:89883240 FANCA 0.89 15.0 0.68 2.95e-37 Vitiligo; CESC cis rs9346455 0.881 rs9354993 chr6:72030526 A/G cg27238071 chr6:71998145 OGFRL1 0.6 5.07 0.3 7.56e-7 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg22433210 chr17:43662623 NA -0.63 -8.1 -0.45 2e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs854765 0.583 rs9890341 chr17:17823175 G/C cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.93e-9 Total body bone mineral density; CESC cis rs854765 0.693 rs9907287 chr17:17774118 C/T cg09796270 chr17:17721594 SREBF1 -0.4 -5.58 -0.32 6.08e-8 Total body bone mineral density; CESC cis rs1878931 0.543 rs17612463 chr16:3420479 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.71 8.83 0.48 1.51e-16 Body mass index (adult); CESC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg27125505 chr17:43679177 LOC644172 0.5 6.51 0.37 3.7e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7107174 0.711 rs66583694 chr11:78037773 C/T cg02023728 chr11:77925099 USP35 0.4 5.88 0.34 1.24e-8 Testicular germ cell tumor; CESC cis rs863345 0.604 rs1578763 chr1:158497414 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.78e-11 Pneumococcal bacteremia; CESC cis rs5769765 1.000 rs34774661 chr22:50267508 C/G cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10164272 chr16:89456328 ANKRD11 0.48 6.61 0.38 2.09e-10 Fibrinogen levels; CESC cis rs863345 0.604 rs1578762 chr1:158497440 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.78e-11 Pneumococcal bacteremia; CESC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg09359103 chr1:154839909 KCNN3 0.64 12.44 0.61 2.74e-28 Prostate cancer; CESC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs853679 1.000 rs853678 chr6:28297313 T/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.68 7.15 0.4 8.65e-12 Depression; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07080220 chr10:102295463 HIF1AN -0.54 -7.28 -0.41 3.78e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs677673 0.953 rs632424 chr20:10479545 T/C cg16021678 chr13:55475951 NA 0.52 6.51 0.37 3.77e-10 Body mass index (change over time) in chronic obstructive pulmonary disease; CESC trans rs9596009 0.591 rs959353 chr13:49344662 G/C cg13176070 chr2:32503943 YIPF4 0.52 6.07 0.35 4.5e-9 Cough in response to angiotensin-converting enzyme inhibitor drugs; CESC cis rs72945132 0.556 rs57172967 chr11:70160060 G/A cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg12311346 chr5:56204834 C5orf35 -0.74 -8.76 -0.47 2.43e-16 Initial pursuit acceleration; CESC cis rs35110281 0.627 rs56369437 chr21:44970275 A/G cg04455712 chr21:45112962 RRP1B 0.36 5.46 0.32 1.07e-7 Mean corpuscular volume; CESC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg04369109 chr6:150039330 LATS1 -0.43 -5.96 -0.34 7.97e-9 Lung cancer; CESC cis rs7659604 0.592 rs56077950 chr4:122721412 C/T cg20573242 chr4:122745356 CCNA2 0.57 6.92 0.39 3.45e-11 Type 2 diabetes; CESC cis rs6580649 0.783 rs7969749 chr12:48550755 C/T cg05342945 chr12:48394962 COL2A1 -0.54 -6.06 -0.35 4.78e-9 Lung cancer; CESC trans rs61931739 0.500 rs11053167 chr12:34387092 A/C cg26384229 chr12:38710491 ALG10B 0.67 10.2 0.53 7.78e-21 Morning vs. evening chronotype; CESC cis rs9788682 0.948 rs34664138 chr15:78831624 T/G cg06917634 chr15:78832804 PSMA4 -0.55 -6.49 -0.37 4.15e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12780433 chr3:159481918 SCHIP1 0.52 6.05 0.35 4.82e-9 Gut microbiome composition (summer); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg06128920 chr1:1447374 ATAD3A 0.4 6.19 0.36 2.27e-9 Vertical cup-disc ratio; CESC cis rs644799 1.000 rs472231 chr11:95532166 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs62064224 0.589 rs2285428 chr17:30820176 C/T cg18200150 chr17:30822561 MYO1D -0.4 -5.12 -0.3 6.02e-7 Schizophrenia; CESC cis rs1775715 0.870 rs1775731 chr10:32253512 A/G cg04359828 chr10:32216031 ARHGAP12 0.35 5.17 0.3 4.72e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs10883723 0.810 rs6584507 chr10:104254623 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs12971120 0.504 rs11665154 chr18:72147006 A/C cg25817165 chr18:72167213 CNDP2 -0.43 -6.08 -0.35 4.16e-9 Refractive error; CESC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg27121462 chr16:89883253 FANCA 0.75 10.84 0.55 6.6e-23 Vitiligo; CESC cis rs3096299 0.967 rs28575874 chr16:89469890 C/T cg02187348 chr16:89574699 SPG7 0.57 7.68 0.43 3.15e-13 Multiple myeloma (IgH translocation); CESC cis rs708547 0.647 rs12621 chr4:57897570 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.43 -5.53 -0.32 7.67e-8 Response to bleomycin (chromatid breaks); CESC cis rs7592578 0.771 rs12053190 chr2:191383348 A/G cg27211696 chr2:191398769 TMEM194B -0.62 -5.63 -0.33 4.7e-8 Diastolic blood pressure; CESC cis rs7927771 0.832 rs7940536 chr11:47395240 G/A cg05585544 chr11:47624801 NA 0.49 7.2 0.4 6.32e-12 Subjective well-being; CESC cis rs7809950 1.000 rs2520264 chr7:107179344 T/C cg23024343 chr7:107201750 COG5 -0.42 -5.88 -0.34 1.22e-8 Coronary artery disease; CESC cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4969178 0.965 rs8071889 chr17:76398101 A/G cg20026190 chr17:76395443 PGS1 0.49 7.82 0.43 1.25e-13 HDL cholesterol levels; CESC cis rs6933660 0.744 rs35143743 chr6:151768532 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.47 5.42 0.32 1.33e-7 Menarche (age at onset); CESC cis rs12477438 0.834 rs6757019 chr2:99676936 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs7843479 0.965 rs2291317 chr8:21827162 C/T cg17168535 chr8:21777572 XPO7 0.57 7.79 0.43 1.48e-13 Mean corpuscular volume; CESC cis rs12579753 0.833 rs12579530 chr12:82163930 A/C cg23701643 chr12:82153290 PPFIA2 -0.35 -5.06 -0.3 7.93e-7 Resting heart rate; CESC trans rs2589561 0.872 rs2440781 chr10:9051328 A/G cg09169283 chr17:72856452 GRIN2C 0.53 6.46 0.37 4.97e-10 Asthma; CESC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.86 7.35 0.41 2.53e-12 Depression; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19947233 chr4:90032727 TIGD2 -0.47 -6.03 -0.35 5.55e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11190604 1.000 rs6584379 chr10:102224490 G/A cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg24110177 chr3:50126178 RBM5 -0.56 -7.75 -0.43 1.95e-13 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15208247 chr1:244857838 PPPDE1 -0.58 -6.3 -0.36 1.25e-9 Gut microbiome composition (summer); CESC cis rs12791968 0.765 rs12794846 chr11:44998943 C/T cg11846598 chr11:44996168 LOC221122 0.49 5.89 0.34 1.18e-8 Inhibitory control; CESC cis rs2304069 0.954 rs2340462 chr5:149415219 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.82 10.24 0.53 5.96e-21 HIV-1 control; CESC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg08859206 chr1:53392774 SCP2 0.6 8.96 0.48 5.95e-17 Monocyte count; CESC trans rs728996 0.561 rs1326559 chr6:51652335 A/G cg15101985 chr10:85961501 PCDH21 -0.47 -6.17 -0.35 2.53e-9 Weight loss (gastric bypass surgery); CESC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg06873352 chr17:61820015 STRADA 0.72 12.56 0.61 1.02e-28 Prudent dietary pattern; CESC cis rs2415984 0.600 rs61993299 chr14:46944880 A/C cg14871534 chr14:47121158 RPL10L -0.37 -5.61 -0.33 4.98e-8 Number of children ever born; CESC cis rs2404602 0.692 rs1838048 chr15:76931679 A/G cg26408565 chr15:76604113 ETFA -0.38 -5.44 -0.32 1.21e-7 Blood metabolite levels; CESC cis rs1580019 0.547 rs56981934 chr7:32535202 C/G cg06627557 chr7:32535165 LSM5;AVL9 1.09 20.08 0.78 3.92e-55 Cognitive ability; CESC cis rs80282103 0.618 rs1079390 chr10:1161653 C/A cg08668510 chr10:1095578 IDI1 0.72 5.84 0.34 1.55e-8 Glomerular filtration rate (creatinine); CESC cis rs9902453 0.874 rs62070271 chr17:28268358 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 9.16 0.49 1.49e-17 Coffee consumption (cups per day); CESC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC cis rs6964587 0.967 rs58673519 chr7:91823887 T/G cg17063962 chr7:91808500 NA 0.58 7.9 0.44 7.4e-14 Breast cancer; CESC cis rs921968 0.541 rs2556391 chr2:219556346 T/C cg02176678 chr2:219576539 TTLL4 -0.56 -9.86 -0.52 1.01e-19 Mean corpuscular hemoglobin concentration; CESC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg17724175 chr1:150552817 MCL1 0.42 6.34 0.36 1e-9 Melanoma; CESC cis rs9291683 0.609 rs13141233 chr4:10028729 T/C cg00071950 chr4:10020882 SLC2A9 0.89 16.34 0.71 5.39e-42 Bone mineral density; CESC cis rs60154123 0.772 rs845452 chr1:210417861 C/T cg21951975 chr1:209979733 IRF6 0.49 6.12 0.35 3.35e-9 Coronary artery disease; CESC trans rs9467711 0.606 rs9379899 chr6:26603015 T/A cg01620082 chr3:125678407 NA -0.64 -6.33 -0.36 1.03e-9 Autism spectrum disorder or schizophrenia; CESC cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg03709012 chr19:19516395 GATAD2A 0.99 15.8 0.7 4.37e-40 Tonsillectomy; CESC cis rs71403859 0.502 rs17280181 chr16:71523514 C/T cg08717414 chr16:71523259 ZNF19 -1.01 -9.55 -0.51 8.95e-19 Post bronchodilator FEV1; CESC cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.82 -12.1 -0.6 3.83e-27 Systemic lupus erythematosus; CESC cis rs1707322 1.000 rs4390216 chr1:46266456 C/T cg05343316 chr1:45956843 TESK2 0.44 5.53 0.32 7.85e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs853679 0.556 rs13200214 chr6:28017250 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.89 5.57 0.32 6.14e-8 Depression; CESC cis rs863345 0.967 rs863347 chr1:158536008 C/G cg12129480 chr1:158549410 OR10X1 0.33 6.82 0.39 6.07e-11 Pneumococcal bacteremia; CESC cis rs698833 0.852 rs698774 chr2:44584314 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.56 7.03 0.4 1.74e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1801251 1.000 rs2592105 chr2:233645968 C/G cg08000102 chr2:233561755 GIGYF2 0.66 9.19 0.49 1.22e-17 Coronary artery disease; CESC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs7814319 0.933 rs13260865 chr8:97238472 A/T cg20787634 chr8:97240163 UQCRB -0.63 -8.18 -0.45 1.2e-14 Lung function (FVC); CESC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8114671 0.527 rs6060068 chr20:33415820 T/A cg07148914 chr20:33460835 GGT7 0.41 5.28 0.31 2.71e-7 Height; CESC cis rs3747547 0.892 rs17439509 chr9:38016419 A/C cg13774184 chr9:37916125 SHB -0.71 -6.07 -0.35 4.31e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs78707713 0.836 rs112843485 chr10:71211707 T/C cg12610070 chr10:71211762 TSPAN15 -0.36 -6.48 -0.37 4.36e-10 Venous thromboembolism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24862861 chr10:976594 NA 0.48 6.16 0.35 2.69e-9 Gut microbiota (bacterial taxa); CESC cis rs1348850 0.519 rs1527406 chr2:178525655 C/T cg23306229 chr2:178417860 TTC30B 0.46 5.39 0.31 1.59e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3741151 0.773 rs7931767 chr11:73239207 A/G cg17517138 chr11:73019481 ARHGEF17 1.05 7.72 0.43 2.46e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs10883723 0.810 rs6584508 chr10:104258567 A/G cg22532475 chr10:104410764 TRIM8 -0.34 -5.75 -0.33 2.44e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs2204008 0.837 rs2127955 chr12:37969194 A/G cg26384229 chr12:38710491 ALG10B 0.55 7.85 0.43 1.02e-13 Bladder cancer; CESC cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg04450456 chr4:17643702 FAM184B 0.36 5.15 0.3 5.16e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7818688 1.000 rs11774085 chr8:96020877 G/A cg16049864 chr8:95962084 TP53INP1 0.56 5.04 0.3 8.8e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7089973 0.604 rs10490909 chr10:116593532 C/T cg23260525 chr10:116636907 FAM160B1 0.4 7.41 0.41 1.7e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.21 -0.63 5.95e-31 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13028789 chr6:34856920 ANKS1A;TAF11 -0.48 -6.57 -0.37 2.68e-10 Fibrinogen levels; CESC cis rs1707322 0.721 rs61784796 chr1:46163256 A/G cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3733418 0.860 rs12647427 chr4:165929209 G/A cg10852876 chr4:165953100 TRIM60 -0.46 -5.42 -0.32 1.32e-7 Obesity-related traits; CESC cis rs9403521 0.947 rs7741424 chr6:143981662 G/A cg18240653 chr6:144019428 PHACTR2 -0.5 -5.57 -0.32 6.28e-8 Obesity-related traits; CESC cis rs7523050 0.643 rs34367763 chr1:109400805 C/T cg08274380 chr1:109419600 GPSM2 0.85 5.61 0.33 5.08e-8 Fat distribution (HIV); CESC cis rs523522 0.962 rs4767902 chr12:120910004 C/T cg27279351 chr12:120934652 DYNLL1 0.68 8.74 0.47 2.65e-16 High light scatter reticulocyte count; CESC cis rs916888 0.821 rs199514 chr17:44856881 G/A cg17911788 chr17:44343683 NA 0.55 7.19 0.4 6.57e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Depression; CESC cis rs61931739 0.517 rs10844815 chr12:34245150 G/A cg19457237 chr12:34500585 NA -0.38 -5.34 -0.31 2.04e-7 Morning vs. evening chronotype; CESC cis rs6088580 0.634 rs6059850 chr20:33044784 C/G cg06115741 chr20:33292138 TP53INP2 0.46 5.98 0.34 7.26e-9 Glomerular filtration rate (creatinine); CESC cis rs2637266 0.783 rs846597 chr10:78529114 A/G cg18941641 chr10:78392320 NA 0.42 8.11 0.45 1.91e-14 Pulmonary function; CESC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg06873352 chr17:61820015 STRADA -0.6 -9.63 -0.51 5.11e-19 Prudent dietary pattern; CESC cis rs9611565 0.918 rs2281333 chr22:41749630 T/C cg06481639 chr22:41940642 POLR3H -0.47 -5.48 -0.32 9.79e-8 Vitiligo; CESC trans rs1814175 0.754 rs7103235 chr11:49699191 A/G cg15704280 chr7:45808275 SEPT13 -0.86 -12.5 -0.61 1.71e-28 Height; CESC cis rs1218582 0.688 rs58629129 chr1:154910930 T/C cg24250549 chr1:154909240 PMVK 0.57 7.59 0.42 5.54e-13 Prostate cancer; CESC cis rs748404 0.697 rs504417 chr15:43554226 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.61 8.03 0.44 3.2e-14 Lung cancer; CESC cis rs3736485 0.966 rs7173880 chr15:51785433 C/A cg08986416 chr15:51914746 DMXL2 -0.41 -5.24 -0.31 3.24e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs965469 0.762 rs6515783 chr20:3245006 T/C cg25506879 chr20:3388711 C20orf194 -0.51 -5.55 -0.32 6.97e-8 IFN-related cytopenia; CESC cis rs3857536 0.642 rs7755840 chr6:66891913 A/G cg07460842 chr6:66804631 NA -0.4 -5.23 -0.31 3.47e-7 Blood trace element (Cu levels); CESC cis rs7809950 1.000 rs7786801 chr7:107085889 C/T cg23024343 chr7:107201750 COG5 -0.41 -5.83 -0.34 1.58e-8 Coronary artery disease; CESC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.61e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7584330 0.868 rs67071074 chr2:238395429 T/C cg14458575 chr2:238380390 NA 0.73 10.09 0.53 1.86e-20 Prostate cancer; CESC cis rs12136530 0.774 rs883961 chr1:19781155 G/C cg01832549 chr1:19774989 CAPZB -0.47 -6.86 -0.39 4.91e-11 Lead levels in blood; CESC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg15605315 chr1:45957053 TESK2 0.41 5.24 0.31 3.34e-7 High light scatter reticulocyte count; CESC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg04267008 chr7:1944627 MAD1L1 -0.56 -6.69 -0.38 1.32e-10 Bipolar disorder and schizophrenia; CESC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.22 0.31 3.67e-7 Life satisfaction; CESC cis rs12540874 0.663 rs1451371 chr7:50553051 T/C cg18232548 chr7:50535776 DDC -0.42 -6.12 -0.35 3.42e-9 Systemic sclerosis; CESC cis rs2243480 1.000 rs3885839 chr7:65290403 G/T cg18252515 chr7:66147081 NA -1.18 -11.4 -0.57 9.41e-25 Diabetic kidney disease; CESC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.38 0.31 1.66e-7 Tonsillectomy; CESC trans rs4950322 0.547 rs56864370 chr1:146583429 A/G cg04954894 chr8:38089920 DDHD2 -0.57 -6.23 -0.36 1.84e-9 Protein quantitative trait loci; CESC cis rs2282802 0.635 rs270162 chr5:139539090 A/G cg26211634 chr5:139558579 C5orf32 -0.38 -5.11 -0.3 6.05e-7 Intelligence (multi-trait analysis); CESC cis rs10045504 0.502 rs72746032 chr5:38743982 T/C cg15396434 chr5:38725168 NA -0.72 -6.75 -0.38 9.09e-11 Night sleep phenotypes; CESC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg17178900 chr1:205818956 PM20D1 0.72 10.89 0.56 4.64e-23 Menarche (age at onset); CESC cis rs765787 0.530 rs4775835 chr15:45537553 T/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7089973 0.604 rs2420067 chr10:116590348 A/G cg23260525 chr10:116636907 FAM160B1 0.4 7.19 0.4 6.76e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2228479 0.850 rs17226498 chr16:89840631 T/C cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs6835098 0.961 rs2877748 chr4:174102397 G/A cg08422745 chr4:174089978 GALNT7 -0.71 -9.27 -0.49 6.64e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs7799006 0.757 rs2398668 chr7:2298227 A/G cg08027265 chr7:2291960 NA 0.55 9.76 0.51 1.97e-19 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4588572 0.643 rs13155648 chr5:77755343 A/G cg11547950 chr5:77652471 NA -0.44 -5.48 -0.32 9.67e-8 Triglycerides; CESC trans rs17039065 0.834 rs17039112 chr4:109439739 G/A cg27151770 chr16:49620536 ZNF423 -0.5 -6.01 -0.35 6.02e-9 Gut microbiome composition (summer); CESC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs400736 0.671 rs2472862 chr1:7991203 G/A cg25007680 chr1:8021821 PARK7 -0.57 -8.16 -0.45 1.35e-14 Response to antidepressants and depression; CESC cis rs2267137 0.868 rs174770 chr22:29766895 C/T cg07256473 chr22:29710276 RASL10A 0.42 6.5 0.37 3.92e-10 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22097276 chr17:73937072 FBF1 0.64 7.25 0.41 4.54e-12 Gut microbiome composition (summer); CESC cis rs6545883 0.929 rs1838978 chr2:61540923 T/C cg15711740 chr2:61764176 XPO1 0.44 5.54 0.32 7.36e-8 Tuberculosis; CESC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg24549020 chr5:56110836 MAP3K1 0.66 7.45 0.42 1.29e-12 Initial pursuit acceleration; CESC cis rs2952156 0.876 rs903504 chr17:37829570 C/G cg00129232 chr17:37814104 STARD3 -0.81 -11.81 -0.59 3.71e-26 Asthma; CESC cis rs72781680 0.898 rs72780188 chr2:24006065 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs9399135 0.967 rs9321481 chr6:135352648 C/G cg24558204 chr6:135376177 HBS1L -0.53 -7.11 -0.4 1.06e-11 Red blood cell count; CESC cis rs924607 1.000 rs2455331 chr5:643593 T/C cg09021430 chr5:549028 NA -0.38 -6.71 -0.38 1.15e-10 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs854765 0.663 rs16960744 chr17:17755259 A/G cg09796270 chr17:17721594 SREBF1 -0.46 -6.69 -0.38 1.29e-10 Total body bone mineral density; CESC cis rs933688 1.000 rs11948075 chr5:90680579 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 14.27 0.66 1.16e-34 Smoking behavior; CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg01238044 chr22:24384105 GSTT1 -0.74 -10.23 -0.53 6.2e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13040021 chr20:5093911 C20orf30 -0.44 -6.29 -0.36 1.28e-9 Gambling; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.2.10906491R chr2:10989040 NA 0.46 6.57 0.37 2.59e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs599083 0.530 rs689179 chr11:68179166 A/G cg01657329 chr11:68192670 LRP5 0.44 5.23 0.31 3.39e-7 Bone mineral density (spine); CESC cis rs870825 0.860 rs2705899 chr4:185596219 A/G cg04058563 chr4:185651563 MLF1IP 0.51 5.35 0.31 1.93e-7 Blood protein levels; CESC cis rs11625487 0.957 rs28820314 chr14:77963272 A/C cg20045696 chr14:77926864 AHSA1 -0.6 -6.55 -0.37 3.04e-10 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC trans rs61931739 0.890 rs1705753 chr12:34144594 C/T cg26384229 chr12:38710491 ALG10B 0.48 6.64 0.38 1.8e-10 Morning vs. evening chronotype; CESC cis rs7916697 0.898 rs1900005 chr10:69998055 A/C cg06988349 chr10:69991859 ATOH7 -0.38 -6.22 -0.36 1.88e-9 Optic disc area; CESC cis rs6032067 0.641 rs34919068 chr20:43755830 C/A cg10761708 chr20:43804764 PI3 0.5 5.25 0.31 3.12e-7 Blood protein levels; CESC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg03709012 chr19:19516395 GATAD2A 1.02 15.57 0.69 2.98e-39 Tonsillectomy; CESC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg05872129 chr22:39784769 NA -0.8 -10.0 -0.52 3.43e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9815354 0.812 rs55916959 chr3:41849130 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs599083 0.569 rs685095 chr11:68170376 C/T cg16797656 chr11:68205561 LRP5 -0.42 -5.49 -0.32 9.43e-8 Bone mineral density (spine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08687137 chr11:62389499 B3GAT3 0.55 6.03 0.35 5.63e-9 Gut microbiome composition (summer); CESC cis rs17039065 0.920 rs57594448 chr4:109461514 A/T cg16022748 chr4:109541635 LOC285456;RPL34 0.65 5.9 0.34 1.12e-8 Gut microbiome composition (summer); CESC cis rs7336332 0.598 rs45622135 chr13:28011594 T/C cg01674679 chr13:27998804 GTF3A -0.58 -5.34 -0.31 2.04e-7 Weight; CESC cis rs12325245 0.536 rs34129245 chr16:58588191 A/G cg02549819 chr16:58548995 SETD6 0.96 6.42 0.37 6.42e-10 Schizophrenia; CESC cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg23711669 chr6:146136114 FBXO30 -0.92 -12.48 -0.61 2.03e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7039377 0.541 rs7850196 chr9:38671574 G/T cg14625731 chr9:38672608 NA -0.4 -5.46 -0.32 1.08e-7 Obesity-related traits; CESC cis rs4974559 0.501 rs2101094 chr4:1235643 A/G cg02980000 chr4:1222292 CTBP1 -0.83 -8.54 -0.46 1.03e-15 Systolic blood pressure; CESC cis rs2040771 0.770 rs2518840 chr22:19255856 A/C cg17887427 chr22:19166691 SLC25A1 -0.39 -5.11 -0.3 6.3e-7 Metabolite levels (small molecules and protein measures); CESC cis rs6424115 0.830 rs3123554 chr1:24196401 C/T cg15997130 chr1:24165203 NA -0.4 -5.28 -0.31 2.67e-7 Immature fraction of reticulocytes; CESC cis rs6912958 0.605 rs2754247 chr6:88383571 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.37 -6.02 -0.35 5.81e-9 Monocyte percentage of white cells; CESC cis rs9814567 0.964 rs9815894 chr3:134282796 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.05 -0.35 4.79e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg22535103 chr8:58192502 C8orf71 -0.67 -7.19 -0.4 6.53e-12 Developmental language disorder (linguistic errors); CESC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.46 -6.04 -0.35 5.3e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6963495 0.606 rs6969426 chr7:105147150 G/A cg02135003 chr7:105160482 PUS7 -0.47 -5.63 -0.33 4.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs9486719 1.000 rs11153018 chr6:96956137 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -8.21 -0.45 9.67e-15 Migraine;Coronary artery disease; CESC cis rs8028182 0.636 rs4322627 chr15:75810659 C/T cg20655648 chr15:75932815 IMP3 0.48 5.91 0.34 1.04e-8 Sudden cardiac arrest; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00828305 chr2:178077190 HNRNPA3 0.62 7.19 0.4 6.75e-12 Gut microbiome composition (summer); CESC cis rs4566357 0.930 rs13424003 chr2:227926860 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.45 -0.32 1.16e-7 Coronary artery disease; CESC cis rs10089 1.000 rs4836361 chr5:127459991 T/C cg19767477 chr5:127420684 SLC12A2 -0.4 -5.32 -0.31 2.18e-7 Ileal carcinoids; CESC cis rs1707322 0.963 rs6666763 chr1:46436451 C/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2479724 0.840 rs6925777 chr6:41750822 C/T cg17623882 chr6:41773611 USP49 0.42 5.93 0.34 9.52e-9 Menarche (age at onset); CESC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg17143192 chr8:8559678 CLDN23 -0.48 -5.85 -0.34 1.46e-8 Mood instability; CESC cis rs929354 0.553 rs34498858 chr7:156931337 T/C cg05182265 chr7:156933206 UBE3C -0.49 -7.09 -0.4 1.22e-11 Body mass index; CESC cis rs6842047 0.901 rs2102575 chr4:187131504 G/A cg02012338 chr4:187126139 CYP4V2 0.74 5.88 0.34 1.21e-8 Blood protein levels; CESC cis rs977987 0.762 rs1364079 chr16:75393131 C/A cg03315344 chr16:75512273 CHST6 0.39 5.66 0.33 3.86e-8 Dupuytren's disease; CESC cis rs7666738 0.546 rs10018080 chr4:98758436 C/A cg05340658 chr4:99064831 C4orf37 0.54 6.63 0.38 1.89e-10 Colonoscopy-negative controls vs population controls; CESC cis rs10484885 0.878 rs72921955 chr6:90588789 C/G cg13799429 chr6:90582589 CASP8AP2 -0.8 -7.63 -0.42 4.23e-13 QRS interval (sulfonylurea treatment interaction); CESC cis rs853679 0.607 rs71559070 chr6:28038929 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 5.33 0.31 2.14e-7 Depression; CESC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg09323728 chr8:95962352 TP53INP1 -0.44 -9.67 -0.51 3.93e-19 Type 2 diabetes; CESC cis rs7216064 0.734 rs11653507 chr17:65892064 A/T cg07042672 chr17:66097459 LOC651250 -0.58 -7.1 -0.4 1.14e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1799949 0.965 rs1842147 chr17:41435192 C/T cg25072359 chr17:41440525 NA 0.48 6.46 0.37 4.98e-10 Menopause (age at onset); CESC cis rs644799 0.544 rs56298021 chr11:95545113 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.47 6.18 0.35 2.41e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs921968 0.510 rs620887 chr2:219465594 C/A cg02176678 chr2:219576539 TTLL4 0.48 8.27 0.45 6.35e-15 Mean corpuscular hemoglobin concentration; CESC cis rs7927592 0.956 rs7113287 chr11:68372186 A/T cg16797656 chr11:68205561 LRP5 0.41 6.05 0.35 4.89e-9 Total body bone mineral density; CESC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg24675658 chr1:53192096 ZYG11B 0.54 7.08 0.4 1.28e-11 Monocyte count; CESC cis rs5758659 0.714 rs5751216 chr22:42508937 G/T cg19513890 chr22:42538836 CYP2D7P1 0.36 5.28 0.31 2.71e-7 Cognitive function; CESC cis rs1815787 1 rs1815787 chr11:116921397 T/C cg01368799 chr11:117014884 PAFAH1B2 0.56 5.14 0.3 5.4e-7 Subjective well-being; CESC cis rs72781680 0.898 rs7569424 chr2:24036222 A/G cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg19592336 chr6:28129416 ZNF389 0.62 8.32 0.46 4.64e-15 Depression; CESC cis rs7560272 0.549 rs2421554 chr2:73806202 A/T cg20560298 chr2:73613845 ALMS1 -0.4 -5.45 -0.32 1.14e-7 Schizophrenia; CESC cis rs2760061 0.626 rs596675 chr1:228117892 G/A cg01973587 chr1:228161476 NA 0.35 5.29 0.31 2.55e-7 Diastolic blood pressure; CESC cis rs7523050 0.643 rs12725689 chr1:109405151 T/C cg08274380 chr1:109419600 GPSM2 0.9 5.85 0.34 1.44e-8 Fat distribution (HIV); CESC cis rs9488822 0.676 rs4354188 chr6:116327936 T/C cg15226275 chr6:116381976 FRK 0.25 6.18 0.35 2.39e-9 Cholesterol, total;LDL cholesterol; CESC cis rs3820068 0.581 rs72645888 chr1:15929922 C/A cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs7586673 1.000 rs7586673 chr2:161923520 C/A cg21518248 chr2:162101506 NA 0.47 6.4 0.37 7.14e-10 Intelligence (multi-trait analysis); CESC cis rs7937682 0.575 rs1346180 chr11:111715570 G/C cg09085632 chr11:111637200 PPP2R1B 0.89 11.62 0.58 1.66e-25 Primary sclerosing cholangitis; CESC cis rs896854 0.738 rs481887 chr8:95967838 A/G cg09323728 chr8:95962352 TP53INP1 0.36 6.98 0.39 2.35e-11 Type 2 diabetes; CESC cis rs1451375 0.652 rs1470747 chr7:50627009 C/T cg14593290 chr7:50529359 DDC 0.44 5.34 0.31 2.02e-7 Malaria; CESC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.39 -0.37 7.61e-10 Total body bone mineral density; CESC cis rs4974559 0.947 rs58750335 chr4:1364764 G/A cg02980000 chr4:1222292 CTBP1 0.74 6.56 0.37 2.85e-10 Systolic blood pressure; CESC cis rs13256369 0.802 rs34762800 chr8:8559294 G/A cg17143192 chr8:8559678 CLDN23 0.77 8.63 0.47 5.79e-16 Obesity-related traits; CESC cis rs4481887 0.617 rs28719164 chr1:248543802 T/G cg26353448 chr1:248524236 OR2T4 -0.41 -6.17 -0.35 2.53e-9 Common traits (Other); CESC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.68 -0.33 3.49e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1005277 0.557 rs2983338 chr10:38550734 C/T cg25517755 chr10:38738941 LOC399744 -0.46 -5.94 -0.34 8.7e-9 Extrinsic epigenetic age acceleration; CESC cis rs2295499 0.715 rs2282766 chr4:2658327 G/A cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.16 -0.3 4.74e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs7107174 1.000 rs10899474 chr11:78043636 T/C cg02023728 chr11:77925099 USP35 0.48 6.34 0.36 9.59e-10 Testicular germ cell tumor; CESC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg18876405 chr7:65276391 NA 0.52 6.87 0.39 4.64e-11 Aortic root size; CESC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg21963583 chr11:68658836 MRPL21 0.39 5.66 0.33 3.86e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7647973 0.626 rs2329021 chr3:49679072 G/A cg03060546 chr3:49711283 APEH 0.69 8.34 0.46 4.18e-15 Menarche (age at onset); CESC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg21644426 chr2:191273491 MFSD6 0.48 6.31 0.36 1.17e-9 Pulse pressure; CESC cis rs73110464 0.609 rs4919752 chr12:53359229 G/C cg25025879 chr12:53359317 NA -0.61 -8.13 -0.45 1.7e-14 Cancer (pleiotropy); CESC cis rs4843747 0.709 rs72818521 chr16:88058751 C/G cg06915872 chr16:87998081 BANP 0.59 6.78 0.38 8e-11 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01129751 chr2:42796040 MTA3 0.56 6.02 0.35 5.72e-9 Gut microbiome composition (summer); CESC cis rs4629180 0.701 rs10202801 chr2:102106670 T/C cg21388029 chr2:102003306 CREG2 0.31 5.06 0.3 8e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs67478160 0.654 rs1535097 chr14:104216649 C/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.51 0.54 7.85e-22 Schizophrenia; CESC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.95 0.48 6.28e-17 Menopause (age at onset); CESC cis rs36051895 0.558 rs7038687 chr9:5134065 C/T cg02405213 chr9:5042618 JAK2 0.47 5.96 0.34 8.05e-9 Pediatric autoimmune diseases; CESC trans rs208520 0.955 rs28684412 chr6:66979430 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.33 0.5 4.5e-18 Exhaled nitric oxide output; CESC cis rs7100689 0.622 rs4536152 chr10:82119242 C/T cg00277334 chr10:82204260 NA -0.58 -7.85 -0.43 1.05e-13 Post bronchodilator FEV1; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19508191 chr12:109124361 CORO1C 0.47 6.47 0.37 4.84e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19754536 chr21:32624274 TIAM1 0.47 6.25 0.36 1.61e-9 Fibrinogen levels; CESC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.16e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10658516 chr2:98612531 TMEM131 -0.47 -6.3 -0.36 1.22e-9 Fibrinogen levels; CESC cis rs10463316 0.928 rs4958267 chr5:150752643 A/T cg03212797 chr5:150827313 SLC36A1 -0.52 -6.74 -0.38 9.96e-11 Metabolite levels (Pyroglutamine); CESC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg20999797 chr1:1681921 NA 0.26 5.11 0.3 6.15e-7 Body mass index; CESC cis rs12477438 0.520 rs8179690 chr2:99795300 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.84 -14.61 -0.67 7.35e-36 Chronic sinus infection; CESC cis rs752010 1.000 rs6656183 chr1:42094025 A/G cg06885757 chr1:42089581 HIVEP3 0.49 8.15 0.45 1.43e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs7589342 0.929 rs12053259 chr2:106428720 G/A cg16077055 chr2:106428750 NCK2 0.53 7.57 0.42 6.1e-13 Addiction; CESC cis rs60154123 0.772 rs664072 chr1:210422160 G/A cg23283495 chr1:209979779 IRF6 0.43 5.21 0.3 3.74e-7 Coronary artery disease; CESC cis rs7605827 0.856 rs35549453 chr2:15527220 C/T cg19274914 chr2:15703543 NA 0.36 6.45 0.37 5.37e-10 Educational attainment (years of education); CESC cis rs793571 0.521 rs12594872 chr15:58912749 T/C cg05156742 chr15:59063176 FAM63B 0.77 11.04 0.56 1.47e-23 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22307732 chr7:2559417 LFNG 0.61 7.37 0.41 2.18e-12 Gut microbiome composition (summer); CESC cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg05347473 chr6:146136440 FBXO30 0.57 6.96 0.39 2.75e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg05313129 chr8:58192883 C8orf71 -0.57 -6.47 -0.37 4.59e-10 Developmental language disorder (linguistic errors); CESC cis rs1023500 0.505 rs134891 chr22:42675882 T/C cg04733989 chr22:42467013 NAGA 0.64 9.84 0.52 1.16e-19 Schizophrenia; CESC cis rs7084402 1.000 rs1863665 chr10:60266640 T/C cg07615347 chr10:60278583 BICC1 -0.58 -8.92 -0.48 8.11e-17 Refractive error; CESC cis rs9611565 0.512 rs45500192 chr22:42177899 A/G cg06634786 chr22:41940651 POLR3H -0.67 -6.64 -0.38 1.8e-10 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03269368 chr19:19431604 KIAA0892;SF4 -0.45 -6.55 -0.37 2.91e-10 Fibrinogen levels; CESC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 8.47 0.46 1.68e-15 Platelet count; CESC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg14926445 chr8:58193284 C8orf71 -0.52 -5.59 -0.32 5.77e-8 Developmental language disorder (linguistic errors); CESC cis rs7255436 1.000 rs7255436 chr19:8433196 C/A cg16745616 chr19:8428856 ANGPTL4 -0.37 -5.64 -0.33 4.37e-8 HDL cholesterol; CESC cis rs9325144 0.560 rs7971313 chr12:38653413 A/G cg26384229 chr12:38710491 ALG10B -0.62 -9.6 -0.51 6.43e-19 Morning vs. evening chronotype; CESC trans rs4716602 0.596 rs28451598 chr7:156158974 G/A cg07175507 chr18:77160758 NFATC1 -0.44 -6.09 -0.35 3.91e-9 Anti-saccade response; CESC cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg22875332 chr1:76189707 ACADM -0.62 -6.57 -0.37 2.73e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2764980 1.000 rs2814925 chr10:3284061 A/G cg11630169 chr10:3283847 NA -0.35 -5.13 -0.3 5.54e-7 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs7772486 0.875 rs2814874 chr6:146305895 C/T cg23711669 chr6:146136114 FBXO30 0.9 13.1 0.63 1.45e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg21573476 chr21:45109991 RRP1B -0.45 -6.39 -0.37 7.53e-10 Mean corpuscular volume; CESC cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg03060546 chr3:49711283 APEH 0.49 5.93 0.34 9.54e-9 Parkinson's disease; CESC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg24399712 chr22:39784796 NA -0.81 -10.34 -0.54 2.76e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs4242434 0.892 rs34269854 chr8:22465160 G/C cg03733263 chr8:22462867 KIAA1967 0.95 15.72 0.69 8.78e-40 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs28830936 1.000 rs28830936 chr15:41906408 G/A cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.36 -5.1 -0.3 6.47e-7 Diastolic blood pressure; CESC cis rs9911578 1.000 rs12602346 chr17:56901713 T/C cg12560992 chr17:57184187 TRIM37 0.94 15.75 0.7 6.57e-40 Intelligence (multi-trait analysis); CESC cis rs11098499 1.000 rs3749591 chr4:120214030 T/G cg09307838 chr4:120376055 NA 0.87 11.61 0.58 1.88e-25 Corneal astigmatism; CESC cis rs10489525 0.583 rs1967711 chr1:115630967 C/T cg01522456 chr1:115632236 TSPAN2 0.68 7.83 0.43 1.18e-13 Autism; CESC cis rs10465746 0.570 rs11163886 chr1:84473445 C/A cg10977910 chr1:84465055 TTLL7 0.44 5.54 0.32 7.2e-8 Obesity-related traits; CESC cis rs7520050 0.966 rs6669522 chr1:46397941 A/G cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.64e-8 Red blood cell count;Reticulocyte count; CESC cis rs9911578 1.000 rs12940681 chr17:56933622 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.38 5.06 0.3 7.91e-7 Intelligence (multi-trait analysis); CESC cis rs4604732 0.631 rs11490201 chr1:247626262 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs79349575 0.715 rs62075844 chr17:47002389 G/A cg16584676 chr17:46985605 UBE2Z 0.54 6.7 0.38 1.24e-10 Type 2 diabetes; CESC cis rs7408868 0.656 rs1043997 chr19:15292437 T/C cg14696996 chr19:15285081 NOTCH3 0.77 8.89 0.48 9.75e-17 Pulse pressure; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03556369 chr5:172721020 NA 0.45 6.18 0.35 2.36e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg11764359 chr7:65958608 NA -0.7 -8.85 -0.48 1.25e-16 Cotinine glucuronidation; CESC cis rs7824557 0.767 rs4559208 chr8:11153925 C/G cg21775007 chr8:11205619 TDH 0.46 6.93 0.39 3.28e-11 Retinal vascular caliber; CESC cis rs611744 0.870 rs650925 chr8:109196725 T/C cg21045802 chr8:109455806 TTC35 0.46 5.51 0.32 8.49e-8 Dupuytren's disease; CESC cis rs6580649 0.941 rs1968071 chr12:48489357 A/G cg05342945 chr12:48394962 COL2A1 0.49 5.59 0.32 5.65e-8 Lung cancer; CESC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.61 -0.38 2.12e-10 Electroencephalogram traits; CESC trans rs10500991 0.587 rs73442315 chr11:24887646 G/A cg07129253 chr8:30890560 PURG;WRN -0.49 -6.52 -0.37 3.52e-10 Iron status biomarkers; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06896663 chr8:82754093 SNX16 -0.5 -6.6 -0.38 2.26e-10 Fibrinogen levels; CESC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg04944784 chr2:26401820 FAM59B -0.67 -7.67 -0.43 3.35e-13 Gut microbiome composition (summer); CESC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs4555082 0.874 rs11622166 chr14:105759763 C/A cg13114125 chr14:105738426 BRF1 -0.88 -10.43 -0.54 1.41e-21 Mean platelet volume;Platelet distribution width; CESC cis rs1595825 0.891 rs4422151 chr2:198544183 A/T cg00982548 chr2:198649783 BOLL -0.48 -5.25 -0.31 3.07e-7 Ulcerative colitis; CESC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.51 0.64 5.51e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg07507251 chr3:52567010 NT5DC2 0.42 7.29 0.41 3.61e-12 Bipolar disorder; CESC cis rs7561273 0.586 rs11902756 chr2:24300932 A/G cg01493198 chr2:24299560 SF3B14 0.41 5.04 0.3 8.6e-7 Quantitative traits; CESC cis rs6430585 0.591 rs1374330 chr2:136420908 A/C cg07169764 chr2:136633963 MCM6 1.0 11.16 0.57 5.94e-24 Corneal structure; CESC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.29e-8 Developmental language disorder (linguistic errors); CESC cis rs9905704 0.918 rs12947196 chr17:56902444 G/A cg12560992 chr17:57184187 TRIM37 0.61 7.05 0.4 1.54e-11 Testicular germ cell tumor; CESC cis rs2658782 0.789 rs56091149 chr11:93073640 A/C cg15737290 chr11:93063684 CCDC67 -0.55 -6.86 -0.39 4.79e-11 Pulmonary function decline; CESC cis rs6087990 1.000 rs1007124 chr20:31345752 G/C cg13636640 chr20:31349939 DNMT3B 0.9 16.32 0.71 6.41e-42 Ulcerative colitis; CESC cis rs2204008 0.840 rs7957966 chr12:37953629 A/G cg26384229 chr12:38710491 ALG10B -0.51 -7.24 -0.41 4.85e-12 Bladder cancer; CESC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg17221315 chr6:27791827 HIST1H4J 0.42 5.17 0.3 4.72e-7 Cardiac Troponin-T levels; CESC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.38 5.04 0.3 8.73e-7 Menopause (age at onset); CESC cis rs1371867 0.875 rs1660319 chr8:101337530 A/G cg11906718 chr8:101322791 RNF19A 0.47 6.07 0.35 4.4e-9 Atrioventricular conduction; CESC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC trans rs875971 0.508 rs10253883 chr7:66061138 T/C cg26939375 chr7:64535504 NA -0.53 -7.37 -0.41 2.22e-12 Aortic root size; CESC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg27170947 chr2:26402098 FAM59B -0.87 -9.89 -0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs660899 0.595 rs34224911 chr1:44258341 A/T cg11704212 chr1:44303111 ST3GAL3 -0.38 -5.17 -0.3 4.72e-7 Hypertension risk in short sleep duration; CESC cis rs524281 0.861 rs7946917 chr11:65956577 A/G cg14036092 chr11:66035641 RAB1B -0.59 -6.13 -0.35 3.24e-9 Electroencephalogram traits; CESC cis rs9549367 0.712 rs2316443 chr13:113864837 G/A cg00898013 chr13:113819073 PROZ -0.5 -7.27 -0.41 4.16e-12 Platelet distribution width; CESC cis rs8133932 0.608 rs413246 chr21:47346066 G/A cg14185626 chr21:47401492 COL6A1 -0.48 -5.4 -0.31 1.47e-7 Schizophrenia; CESC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg23758822 chr17:41437982 NA 1.05 16.25 0.71 1.17e-41 Menopause (age at onset); CESC trans rs1945213 0.694 rs12222077 chr11:55848116 T/A cg15704280 chr7:45808275 SEPT13 0.76 7.31 0.41 3.15e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg18350739 chr11:68623251 NA -0.46 -7.1 -0.4 1.15e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7772486 0.713 rs79248977 chr6:146319388 C/A cg23711669 chr6:146136114 FBXO30 0.81 11.43 0.57 7.46e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg19046167 chr17:80928561 B3GNTL1 0.46 5.4 0.31 1.47e-7 Glycated hemoglobin levels; CESC cis rs30380 1.000 rs30378 chr5:96121994 A/G cg16492584 chr5:96139282 ERAP1 -0.36 -5.41 -0.32 1.42e-7 Cerebrospinal fluid biomarker levels; CESC cis rs2243480 1.000 rs73142122 chr7:65311298 C/A cg18252515 chr7:66147081 NA -1.18 -11.4 -0.57 9.2e-25 Diabetic kidney disease; CESC cis rs796364 0.760 rs55906940 chr2:201049386 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.77 -6.49 -0.37 4.29e-10 Schizophrenia; CESC cis rs2635047 0.682 rs7242976 chr18:44797159 T/A cg24371990 chr18:44770781 NA 0.39 6.27 0.36 1.48e-9 Educational attainment; CESC trans rs1728785 1.000 rs7195979 chr16:68586801 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.69 8.13 0.45 1.71e-14 Ulcerative colitis; CESC cis rs829661 0.532 rs2363073 chr2:30796008 A/C cg17749961 chr2:30669863 LCLAT1 -0.44 -5.39 -0.31 1.59e-7 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs208520 1.000 rs12190187 chr6:66973207 T/G cg07460842 chr6:66804631 NA 0.9 10.27 0.53 4.61e-21 Exhaled nitric oxide output; CESC cis rs6088590 0.710 rs6059992 chr20:33282275 T/C cg24642439 chr20:33292090 TP53INP2 0.66 8.77 0.47 2.24e-16 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04915425 chr11:47236385 DDB2 -0.43 -6.21 -0.36 2.04e-9 Gambling; CESC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg23758822 chr17:41437982 NA 1.03 15.68 0.69 1.19e-39 Menopause (age at onset); CESC cis rs7615952 0.673 rs9821905 chr3:125620850 A/G cg05084668 chr3:125655381 ALG1L 0.7 7.73 0.43 2.21e-13 Blood pressure (smoking interaction); CESC cis rs3015497 0.506 rs10144234 chr14:51172219 A/C cg26011998 chr14:51135199 SAV1 0.5 5.68 0.33 3.6e-8 Mean platelet volume; CESC cis rs11785400 1.000 rs4736365 chr8:143742197 A/G cg24634471 chr8:143751801 JRK 0.47 6.2 0.36 2.21e-9 Schizophrenia; CESC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg05863683 chr7:1912471 MAD1L1 0.43 6.35 0.36 9.24e-10 Bipolar disorder and schizophrenia; CESC cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg23711669 chr6:146136114 FBXO30 1.0 15.63 0.69 1.86e-39 Lobe attachment (rater-scored or self-reported); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg16510040 chr1:40042432 PABPC4 0.45 6.05 0.35 4.85e-9 Breast cancer;Type 2 diabetes; CESC trans rs17027633 0.867 rs7543384 chr1:111948014 G/T cg23429042 chr3:32023402 ZNF860;OSBPL10 -0.56 -6.13 -0.35 3.12e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; CESC cis rs6815814 0.950 rs11727978 chr4:38811051 T/A cg02016764 chr4:38805732 TLR1 -0.62 -7.43 -0.42 1.5e-12 Breast cancer; CESC cis rs11122272 0.735 rs2808586 chr1:231515559 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs5769765 0.837 rs4824110 chr22:50271631 T/A cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs1707322 0.964 rs10890358 chr1:46319025 T/A cg06784218 chr1:46089804 CCDC17 0.32 5.48 0.32 1e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs897080 0.515 rs1067321 chr2:44631312 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.88 0.34 1.2e-8 Height; CESC trans rs743002 0.554 rs5751014 chr22:41358092 A/T cg21776993 chr19:1449424 APC2 -0.63 -6.25 -0.36 1.63e-9 Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells;Eosinophil counts; CESC cis rs1707322 0.896 rs785518 chr1:46568422 A/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.63 -0.33 4.67e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs72945132 0.882 rs72945194 chr11:70138621 A/G cg14191688 chr11:70257035 CTTN 0.48 5.7 0.33 3.21e-8 Coronary artery disease; CESC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12703194 chr16:3086867 CCDC64B 0.57 6.7 0.38 1.25e-10 Gut microbiome composition (summer); CESC cis rs690037 0.528 rs568833 chr3:16367836 C/T cg23474789 chr3:16306055 DPH3;OXNAD1 -0.59 -8.1 -0.45 2.05e-14 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); CESC cis rs72781680 1.000 rs72781683 chr2:24247423 T/C cg20701182 chr2:24300061 SF3B14 0.85 7.4 0.41 1.8e-12 Lymphocyte counts; CESC cis rs644799 0.932 rs523934 chr11:95641775 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.43 5.2 0.3 3.99e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.37 -5.48 -0.32 9.66e-8 Electroencephalogram traits; CESC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.57 -0.32 6.33e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs897984 0.762 rs2054213 chr16:30971810 A/G cg00531865 chr16:30841666 NA 0.51 7.01 0.4 2e-11 Dementia with Lewy bodies; CESC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg16325326 chr1:53192061 ZYG11B -0.7 -11.18 -0.57 4.87e-24 Monocyte count; CESC cis rs2108622 0.559 rs7252638 chr19:15981025 G/C cg13772218 chr19:15982569 NA 0.3 5.87 0.34 1.27e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg05283184 chr6:79620031 NA -0.42 -6.43 -0.37 5.98e-10 Intelligence (multi-trait analysis); CESC cis rs10129255 0.957 rs8009464 chr14:107185850 C/T cg07958169 chr14:107095056 NA -0.41 -5.82 -0.34 1.7e-8 Kawasaki disease; CESC cis rs17253792 0.822 rs10137340 chr14:56050989 A/G cg01858014 chr14:56050164 KTN1 -0.76 -6.56 -0.37 2.87e-10 Putamen volume; CESC cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg03433033 chr1:76189801 ACADM -0.62 -6.52 -0.37 3.45e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg06634786 chr22:41940651 POLR3H -0.65 -7.22 -0.41 5.43e-12 Vitiligo; CESC cis rs7618501 0.932 rs4855850 chr3:49761571 G/A cg24308560 chr3:49941425 MST1R 0.51 7.06 0.4 1.48e-11 Intelligence (multi-trait analysis); CESC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg07507251 chr3:52567010 NT5DC2 0.43 7.44 0.42 1.43e-12 Bipolar disorder; CESC cis rs1003719 0.713 rs2835594 chr21:38466064 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs1405069 0.809 rs1063021 chr6:36932327 A/G cg26433444 chr6:36932349 PI16 0.42 8.17 0.45 1.26e-14 Chemerin levels; CESC cis rs9303401 0.659 rs34468504 chr17:56648277 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.93 0.62 5.59e-30 Cognitive test performance; CESC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg02725872 chr8:58115012 NA -0.38 -5.1 -0.3 6.54e-7 Developmental language disorder (linguistic errors); CESC cis rs4523957 0.620 rs898749 chr17:2085185 G/A cg16513277 chr17:2031491 SMG6 -0.71 -10.17 -0.53 1.04e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2228479 0.850 rs17232630 chr16:89851179 C/T cg19635926 chr16:89946313 TCF25 0.67 5.08 0.3 7.08e-7 Skin colour saturation; CESC cis rs12586317 0.547 rs4982234 chr14:35460106 T/A cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs796364 1.000 rs281785 chr2:200749566 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.83 7.81 0.43 1.36e-13 Schizophrenia; CESC cis rs2718058 0.560 rs2709109 chr7:37832852 G/A cg24998770 chr7:37888106 TXNDC3 0.38 5.37 0.31 1.7e-7 Alzheimer's disease (late onset); CESC cis rs9487051 0.735 rs455839 chr6:109524221 G/A cg01475377 chr6:109611718 NA -0.46 -6.91 -0.39 3.52e-11 Reticulocyte fraction of red cells; CESC cis rs72781680 0.950 rs72796343 chr2:24147631 G/A cg08917208 chr2:24149416 ATAD2B 1.11 9.73 0.51 2.43e-19 Lymphocyte counts; CESC trans rs1814175 0.616 rs1722020 chr11:49904189 G/A cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg03352830 chr11:487213 PTDSS2 0.74 7.21 0.4 5.99e-12 Body mass index; CESC cis rs4727027 0.933 rs7788925 chr7:148831621 A/G cg23583168 chr7:148888333 NA -0.73 -10.82 -0.55 7.76e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7520050 0.778 rs3014216 chr1:46035760 A/T cg03146154 chr1:46216737 IPP 0.48 6.17 0.35 2.55e-9 Red blood cell count;Reticulocyte count; CESC cis rs4835473 0.932 rs55862664 chr4:144657464 G/A cg25736465 chr4:144833511 NA -0.32 -5.07 -0.3 7.49e-7 Immature fraction of reticulocytes; CESC cis rs425277 0.583 rs925905 chr1:2044037 T/C cg04315214 chr1:2043799 PRKCZ 0.6 10.44 0.54 1.32e-21 Height; CESC cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg19539972 chr4:7069911 GRPEL1 -0.72 -6.88 -0.39 4.34e-11 Monocyte percentage of white cells; CESC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg22535103 chr8:58192502 C8orf71 -0.95 -10.54 -0.54 6.39e-22 Developmental language disorder (linguistic errors); CESC cis rs6580649 0.882 rs59766465 chr12:48470169 G/A cg05342945 chr12:48394962 COL2A1 0.5 5.74 0.33 2.59e-8 Lung cancer; CESC cis rs2072732 0.861 rs10909866 chr1:2960372 C/T cg15211996 chr1:2936768 ACTRT2 0.35 5.87 0.34 1.31e-8 Plateletcrit; CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg07507251 chr3:52567010 NT5DC2 0.35 6.61 0.38 2.07e-10 Bipolar disorder; CESC cis rs6815814 0.699 rs11730390 chr4:38881414 T/C cg02016764 chr4:38805732 TLR1 -0.62 -6.87 -0.39 4.61e-11 Breast cancer; CESC cis rs7130144 0.541 rs57851196 chr11:130465218 T/C cg26307797 chr11:130446613 NA -0.79 -7.11 -0.4 1.07e-11 Urate levels in lean individuals; CESC cis rs763121 0.853 rs2281019 chr22:39064378 T/A cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.58e-7 Menopause (age at onset); CESC cis rs10129255 0.957 rs7493713 chr14:107191922 T/C cg07958169 chr14:107095056 NA -0.4 -5.52 -0.32 8.02e-8 Kawasaki disease; CESC trans rs7726839 0.561 rs56410216 chr5:583216 C/A cg25482853 chr8:67687455 SGK3 0.88 9.24 0.49 8.24e-18 Obesity-related traits; CESC cis rs79349575 0.783 rs62075820 chr17:46983171 G/C cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg14403583 chr14:105418241 AHNAK2 -0.58 -8.07 -0.44 2.5e-14 Rheumatoid arthritis; CESC cis rs763121 0.853 rs5757211 chr22:39051705 C/T cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC cis rs9354308 0.868 rs9363460 chr6:66557539 C/A cg07460842 chr6:66804631 NA -0.42 -5.03 -0.3 8.94e-7 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11184091 chr9:131843633 DOLPP1 0.56 6.5 0.37 3.9e-10 Gut microbiome composition (summer); CESC cis rs4835473 0.900 rs5015758 chr4:144659205 G/A cg25736465 chr4:144833511 NA -0.33 -5.2 -0.3 4.04e-7 Immature fraction of reticulocytes; CESC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.78 0.38 8.01e-11 Electroencephalogram traits; CESC cis rs965469 1.000 rs2236106 chr20:3278410 A/C cg25506879 chr20:3388711 C20orf194 -0.54 -5.88 -0.34 1.24e-8 IFN-related cytopenia; CESC cis rs478304 0.903 rs495961 chr11:65540886 C/T cg08755490 chr11:65554678 OVOL1 0.47 6.14 0.35 3.06e-9 Acne (severe); CESC cis rs17253792 0.822 rs2296181 chr14:56107051 G/A cg01858014 chr14:56050164 KTN1 -0.85 -7.03 -0.4 1.73e-11 Putamen volume; CESC cis rs4076764 0.522 rs4265409 chr1:163414559 C/T cg24596788 chr1:163392923 NA -0.35 -5.15 -0.3 5.16e-7 Motion sickness; CESC cis rs79349575 0.715 rs11657238 chr17:46985634 A/G cg16584676 chr17:46985605 UBE2Z 0.72 9.58 0.51 7.19e-19 Type 2 diabetes; CESC cis rs1545257 0.537 rs2702089 chr2:24643291 A/G cg06627628 chr2:24431161 ITSN2 0.46 5.66 0.33 3.95e-8 Sjögren's syndrome; CESC cis rs3857536 0.740 rs4710571 chr6:66890250 T/C cg07460842 chr6:66804631 NA -0.41 -5.36 -0.31 1.82e-7 Blood trace element (Cu levels); CESC cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.3 0.36 1.21e-9 Menopause (age at onset); CESC cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg17366294 chr4:99064904 C4orf37 0.61 8.61 0.47 6.71e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.597 rs412754 chr6:109522057 G/C cg01475377 chr6:109611718 NA -0.39 -5.15 -0.3 5.18e-7 Reticulocyte fraction of red cells; CESC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg03351412 chr1:154909251 PMVK 0.48 5.91 0.34 1.03e-8 Prostate cancer; CESC cis rs727505 0.954 rs59670428 chr7:124520966 C/A cg23710748 chr7:124431027 NA -0.4 -6.46 -0.37 4.92e-10 Lewy body disease; CESC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg24675658 chr1:53192096 ZYG11B 0.64 9.0 0.48 4.44e-17 Monocyte count; CESC cis rs2228479 0.681 rs62052184 chr16:89967217 T/C cg00800038 chr16:89945340 TCF25 -0.59 -6.29 -0.36 1.33e-9 Skin colour saturation; CESC cis rs67478160 0.643 rs2295145 chr14:104202304 G/A cg01849466 chr14:104193079 ZFYVE21 -0.52 -7.26 -0.41 4.37e-12 Schizophrenia; CESC cis rs10870270 1.000 rs4880250 chr10:133773919 G/A cg17892150 chr10:133769511 PPP2R2D -0.85 -12.48 -0.61 2.02e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs6460942 0.597 rs6968664 chr7:12515493 T/C cg02935154 chr7:12443704 VWDE -0.48 -5.09 -0.3 6.85e-7 Coronary artery disease; CESC cis rs7264396 0.887 rs224363 chr20:34062710 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -5.11 -0.3 6.12e-7 Total cholesterol levels; CESC cis rs7621025 0.664 rs6439657 chr3:136494639 C/T cg15507776 chr3:136538369 TMEM22 -0.53 -6.28 -0.36 1.37e-9 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs3816788 0.596 rs4872083 chr8:21770372 C/T cg17168535 chr8:21777572 XPO7 0.63 9.57 0.51 8e-19 Lung cancer in ever smokers; CESC cis rs2281558 0.754 rs73597824 chr20:25591477 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.51 6.91 0.39 3.68e-11 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs72781680 0.821 rs72796401 chr2:24180078 T/A cg08917208 chr2:24149416 ATAD2B 0.69 6.74 0.38 1e-10 Lymphocyte counts; CESC cis rs2806561 0.929 rs6694445 chr1:23540428 A/G cg12483005 chr1:23474871 LUZP1 0.32 5.23 0.31 3.41e-7 Height; CESC cis rs9899728 0.764 rs7219493 chr17:73044188 T/C cg27626185 chr17:73056755 KCTD2 -0.61 -6.08 -0.35 4.26e-9 Alzheimer's disease or small vessel stroke; CESC cis rs7149337 0.836 rs4901087 chr14:51668499 T/C cg23942311 chr14:51606299 NA 0.44 7.41 0.41 1.67e-12 Cancer; CESC cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg20848291 chr7:100343083 ZAN -0.63 -6.66 -0.38 1.59e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8077889 0.619 rs1230399 chr17:41845403 C/T cg26893861 chr17:41843967 DUSP3 -1.02 -19.07 -0.76 1.3e-51 Triglycerides; CESC cis rs12541635 0.677 rs1429681 chr8:107048808 A/C cg10147462 chr8:107024639 NA 0.47 6.97 0.39 2.46e-11 Age of smoking initiation; CESC cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg11366901 chr6:160182831 ACAT2 0.77 9.69 0.51 3.29e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs4629180 1.000 rs4851457 chr2:102091220 C/T cg01388757 chr2:102091195 RFX8 0.44 6.62 0.38 1.94e-10 Chronic rhinosinusitis with nasal polyps; CESC cis rs1538970 0.924 rs1006216 chr1:45909994 A/G cg06784218 chr1:46089804 CCDC17 0.35 5.54 0.32 7.26e-8 Platelet count; CESC trans rs6759922 1.000 rs13387284 chr2:22448133 G/A cg21162304 chr4:80247171 NAA11 0.37 6.08 0.35 4.24e-9 Subjective well-being (multi-trait analysis); CESC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg07090678 chr1:91966139 CDC7 0.41 5.65 0.33 4.1e-8 Breast cancer; CESC cis rs7089973 0.604 rs7919649 chr10:116609576 T/C cg23260525 chr10:116636907 FAM160B1 0.37 6.71 0.38 1.21e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg19046167 chr17:80928561 B3GNTL1 0.46 5.51 0.32 8.46e-8 Glycated hemoglobin levels; CESC cis rs3820068 0.581 rs78175477 chr1:15948091 C/G cg16988262 chr1:15930761 NA 0.34 5.45 0.32 1.13e-7 Systolic blood pressure; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg10807698 chr14:103243805 TRAF3 0.48 6.37 0.36 8.47e-10 Bronchopulmonary dysplasia; CESC cis rs9916302 0.821 rs4795386 chr17:37746847 A/G cg15445000 chr17:37608096 MED1 0.34 5.19 0.3 4.1e-7 Glomerular filtration rate (creatinine); CESC cis rs910316 1.000 rs175492 chr14:75545220 A/C cg08847533 chr14:75593920 NEK9 0.97 18.89 0.76 5.36e-51 Height; CESC cis rs919433 0.750 rs788012 chr2:198229856 A/T cg03934865 chr2:198174659 NA 0.43 6.18 0.35 2.41e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg05234568 chr11:5960015 NA -0.63 -7.49 -0.42 1.03e-12 DNA methylation (variation); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16341945 chr7:111846878 ZNF277;DOCK4 0.47 6.61 0.38 2.13e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6732160 0.845 rs13413175 chr2:73389916 T/C cg01422370 chr2:73384389 NA 0.44 7.58 0.42 5.72e-13 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs2228479 0.618 rs62052174 chr16:89950901 G/A cg06558623 chr16:89946397 TCF25 1.06 8.98 0.48 5.17e-17 Skin colour saturation; CESC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg18876405 chr7:65276391 NA -0.51 -6.0 -0.35 6.32e-9 Aortic root size; CESC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.75e-12 Tonsillectomy; CESC cis rs7914558 0.966 rs10450373 chr10:104728616 T/C cg15744005 chr10:104629667 AS3MT -0.33 -5.28 -0.31 2.64e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00629816 chr9:37784931 EXOSC3 -0.48 -6.29 -0.36 1.28e-9 Height; CESC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg23281280 chr6:28129359 ZNF389 0.53 7.13 0.4 9.73e-12 Parkinson's disease; CESC cis rs344364 0.511 rs1657134 chr16:1953127 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.53 -5.93 -0.34 9.43e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg00074818 chr8:8560427 CLDN23 -0.36 -5.47 -0.32 1.05e-7 Obesity-related traits; CESC cis rs12200560 0.505 rs4240555 chr6:97076274 T/C cg06623918 chr6:96969491 KIAA0776 0.51 6.46 0.37 5.04e-10 Coronary heart disease; CESC cis rs12822507 0.899 rs4763859 chr12:12787005 G/A cg04607235 chr12:12878440 APOLD1 -0.5 -6.45 -0.37 5.29e-10 Systemic lupus erythematosus; CESC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 10.95 0.56 2.82e-23 Platelet count; CESC cis rs546131 0.600 rs525202 chr11:34821948 A/C cg11058730 chr11:34937778 PDHX;APIP 0.42 5.17 0.3 4.61e-7 Lung disease severity in cystic fibrosis; CESC cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg07636037 chr3:49044803 WDR6 1.01 18.66 0.75 3.36e-50 Parkinson's disease; CESC trans rs875971 1.000 rs2420168 chr7:65630631 C/G cg26939375 chr7:64535504 NA -0.46 -6.09 -0.35 4e-9 Aortic root size; CESC cis rs3008870 1.000 rs2985794 chr1:67425311 T/G cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs6964587 0.934 rs1544377 chr7:91687351 A/G cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.45e-15 Breast cancer; CESC trans rs116095464 0.558 rs6866776 chr5:264495 C/T cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.38e-11 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12720424 chr1:94713229 NA -0.51 -7.24 -0.41 4.91e-12 Gut microbiota (bacterial taxa); CESC cis rs10131894 0.611 rs174994 chr14:75434102 A/G cg11812906 chr14:75593930 NEK9 -0.67 -10.02 -0.52 3e-20 Coronary artery disease; CESC cis rs7851660 0.809 rs7031386 chr9:100665669 G/T cg13688889 chr9:100608707 NA -0.63 -8.95 -0.48 6.33e-17 Strep throat; CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg15112475 chr7:1198522 ZFAND2A -0.4 -6.25 -0.36 1.6e-9 Longevity;Endometriosis; CESC cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg17211192 chr8:82754475 SNX16 -0.55 -7.03 -0.4 1.71e-11 Diastolic blood pressure; CESC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs727505 1.000 rs56313563 chr7:124507003 G/A cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs561341 0.941 rs736678 chr17:30347423 G/T cg19193384 chr17:30244184 NA -0.71 -6.43 -0.37 6.05e-10 Hip circumference adjusted for BMI; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg18851521 chr18:268131 THOC1 0.43 6.0 0.35 6.6e-9 Prevalent atrial fibrillation; CESC cis rs11785693 0.862 rs62491169 chr8:4986425 C/A cg26367366 chr8:4980734 NA 0.92 8.42 0.46 2.35e-15 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs590820 0.712 rs2144300 chr1:230294916 C/T cg20703242 chr1:230279135 GALNT2 0.3 5.04 0.3 8.63e-7 Metabolite levels (lipoprotein measures); CESC cis rs6088580 0.634 rs4911419 chr20:32995873 G/A cg06115741 chr20:33292138 TP53INP2 -0.46 -5.98 -0.34 7.28e-9 Glomerular filtration rate (creatinine); CESC trans rs561341 1.000 rs72821952 chr17:30248133 T/A cg27661571 chr11:113659931 NA -0.83 -7.52 -0.42 8.25e-13 Hip circumference adjusted for BMI; CESC cis rs72634258 0.520 rs12078018 chr1:7857309 G/A cg26816564 chr1:7831052 VAMP3 0.65 6.0 0.35 6.58e-9 Inflammatory bowel disease; CESC cis rs6840258 0.825 rs79998318 chr4:87954166 A/G cg08197287 chr4:87952173 AFF1 -0.4 -5.54 -0.32 7.19e-8 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs7208859 0.623 rs11657990 chr17:29124200 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.49 0.37 4.12e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg23161317 chr6:28129485 ZNF389 0.47 5.84 0.34 1.53e-8 Depression; CESC cis rs4535700 0.501 rs11765531 chr7:56010287 C/G cg09872392 chr7:56161020 PHKG1 0.41 5.9 0.34 1.08e-8 Macular telangiectasia type 2; CESC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg02725872 chr8:58115012 NA -0.44 -6.89 -0.39 3.94e-11 Developmental language disorder (linguistic errors); CESC cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9309473 1.000 rs62151652 chr2:73700131 A/C cg20560298 chr2:73613845 ALMS1 -0.55 -7.15 -0.4 8.23e-12 Metabolite levels; CESC trans rs7746199 0.736 rs34573979 chr6:27480526 C/T cg21479132 chr6:26055353 NA 0.85 6.39 0.37 7.39e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs2050392 0.858 rs2250569 chr10:30698914 G/C cg18806716 chr10:30721971 MAP3K8 -0.42 -6.16 -0.35 2.71e-9 Inflammatory bowel disease; CESC cis rs10028773 0.506 rs12374346 chr4:120281705 G/A cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Educational attainment; CESC cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg27347728 chr4:17578864 LAP3 -0.45 -5.21 -0.3 3.78e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.0 0.8 9.67e-62 Prudent dietary pattern; CESC cis rs2573652 0.722 rs12914189 chr15:100544429 A/T cg00587665 chr15:100533223 ADAMTS17 0.39 6.49 0.37 4.25e-10 Height; CESC cis rs7827545 1.000 rs4909481 chr8:135564555 A/G cg17885191 chr8:135476712 NA 0.48 6.36 0.36 8.96e-10 Hypertension (SNP x SNP interaction); CESC cis rs5769765 1.000 rs4824106 chr22:50267822 T/C cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs17376456 0.825 rs17314797 chr5:93234845 T/A cg25358565 chr5:93447407 FAM172A 1.09 10.53 0.54 6.82e-22 Diabetic retinopathy; CESC cis rs12900413 0.687 rs34484228 chr15:90304067 A/G cg24249390 chr15:90295951 MESP1 -0.41 -5.63 -0.33 4.5e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs12477438 0.798 rs972768 chr2:99682397 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC trans rs6076699 0.623 rs297757 chr20:4503605 C/T cg03800178 chr7:109217284 NA -0.75 -6.0 -0.35 6.48e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (smoking interaction); CESC trans rs1814175 0.676 rs1721999 chr11:49917372 A/G cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg07701084 chr6:150067640 NUP43 0.46 6.54 0.37 3.15e-10 Lung cancer; CESC cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7678296 1.000 rs7678296 chr4:37182646 T/C cg06805348 chr4:37245195 KIAA1239 0.44 5.18 0.3 4.32e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.64 0.43 3.85e-13 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16756419 chr11:6704627 MRPL17 0.59 7.07 0.4 1.39e-11 Gut microbiome composition (summer); CESC cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg10556349 chr10:835070 NA 0.77 6.43 0.37 5.91e-10 Eosinophil percentage of granulocytes; CESC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg18876405 chr7:65276391 NA 0.7 9.88 0.52 8.55e-20 Aortic root size; CESC cis rs9399135 0.660 rs9376072 chr6:135280519 G/C cg22676075 chr6:135203613 NA 0.48 6.75 0.38 9.45e-11 Red blood cell count; CESC cis rs478304 0.651 rs12225620 chr11:65505448 T/C cg27068330 chr11:65405492 SIPA1 -0.45 -5.46 -0.32 1.08e-7 Acne (severe); CESC cis rs1348850 0.632 rs12471621 chr2:178502353 T/C cg22681709 chr2:178499509 PDE11A -0.57 -8.86 -0.48 1.18e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09856797 chr16:67980139 SLC12A4 -0.48 -6.03 -0.35 5.51e-9 Gut microbiome composition (summer); CESC cis rs4662945 0.737 rs4662950 chr2:130238492 A/G cg05903289 chr2:130345205 NA -0.35 -5.45 -0.32 1.13e-7 Response to cytidine analogues (gemcitabine); CESC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg23978390 chr7:1156363 C7orf50 0.54 7.18 0.4 7.04e-12 Longevity;Endometriosis; CESC cis rs7944584 0.611 rs10838696 chr11:47363285 A/G cg20307385 chr11:47447363 PSMC3 -0.69 -8.69 -0.47 3.92e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs2487048 0.773 rs2472494 chr9:107695539 T/C cg14470647 chr9:107690075 ABCA1 -0.47 -5.51 -0.32 8.54e-8 Intraocular pressure; CESC cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg19717773 chr7:2847554 GNA12 -0.54 -8.47 -0.46 1.68e-15 Height; CESC cis rs863345 0.526 rs863931 chr1:158612236 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -5.77 -0.33 2.16e-8 Pneumococcal bacteremia; CESC cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg08847533 chr14:75593920 NEK9 1.02 19.66 0.77 1.08e-53 Height; CESC cis rs834811 0.831 rs834810 chr7:135879825 T/C cg01726295 chr7:135938950 NA 0.37 6.3 0.36 1.23e-9 Post-traumatic stress disorder; CESC cis rs7937682 0.632 rs4935811 chr11:111679262 C/T cg22437258 chr11:111473054 SIK2 -0.52 -5.67 -0.33 3.75e-8 Primary sclerosing cholangitis; CESC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg09877947 chr5:131593287 PDLIM4 0.4 5.07 0.3 7.56e-7 Blood metabolite levels; CESC cis rs916888 0.773 rs199447 chr17:44812188 C/T cg17911788 chr17:44343683 NA -0.61 -7.97 -0.44 4.66e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18466340 chr20:50417476 SALL4 -0.65 -7.66 -0.43 3.43e-13 Gut microbiome composition (summer); CESC trans rs57221529 0.766 rs4527146 chr5:555236 A/G cg25482853 chr8:67687455 SGK3 1.03 10.82 0.55 8.03e-23 Lung disease severity in cystic fibrosis; CESC cis rs6582630 0.555 rs10880624 chr12:38526316 C/T cg26384229 chr12:38710491 ALG10B 0.73 11.35 0.57 1.32e-24 Drug-induced liver injury (flucloxacillin); CESC cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.36 5.91 0.34 1.04e-8 Hemoglobin concentration; CESC cis rs6732160 0.809 rs13406142 chr2:73384098 A/G cg01422370 chr2:73384389 NA 0.43 7.35 0.41 2.5e-12 Intelligence (multi-trait analysis); CESC trans rs1908814 0.516 rs4367597 chr8:11793529 C/T cg15556689 chr8:8085844 FLJ10661 0.52 6.39 0.37 7.33e-10 Neuroticism; CESC cis rs8005677 0.828 rs34584578 chr14:23411690 C/T cg01529538 chr14:23388837 RBM23 0.44 5.83 0.34 1.63e-8 Cognitive ability (multi-trait analysis); CESC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg20999797 chr1:1681921 NA 0.26 5.12 0.3 6.01e-7 Body mass index; CESC cis rs2573652 0.722 rs8034841 chr15:100541593 G/T cg00587665 chr15:100533223 ADAMTS17 -0.39 -6.17 -0.35 2.56e-9 Height; CESC cis rs1707322 1.000 rs1707317 chr1:46510642 C/T cg03146154 chr1:46216737 IPP -0.76 -10.26 -0.53 5.18e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs9325144 0.600 rs12424410 chr12:38758035 A/T cg23762105 chr12:34175262 ALG10 0.48 6.23 0.36 1.84e-9 Morning vs. evening chronotype; CESC cis rs10905065 1.000 rs7913067 chr10:5787305 C/T cg11519256 chr10:5708881 ASB13 0.41 5.42 0.32 1.32e-7 Menopause (age at onset); CESC trans rs459571 0.834 rs379417 chr9:136890704 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.6 -7.73 -0.43 2.3e-13 Platelet distribution width; CESC cis rs796364 0.951 rs7608668 chr2:201000017 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.64 -6.49 -0.37 4.16e-10 Schizophrenia; CESC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg13628971 chr7:2884303 GNA12 -0.61 -7.88 -0.44 8.41e-14 Height; CESC cis rs4900538 0.855 rs1210074 chr14:102889098 G/A cg18135206 chr14:102964638 TECPR2 -0.75 -9.62 -0.51 5.62e-19 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs1814175 0.645 rs847635 chr11:49923323 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs60154123 0.772 rs845452 chr1:210417861 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.49 5.03 0.3 8.94e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04026000 chr5:79628372 NA -0.6 -7.15 -0.4 8.22e-12 Gut microbiome composition (summer); CESC cis rs9304742 0.962 rs1808106 chr19:53452944 T/G cg09915433 chr19:53449742 NA -0.38 -5.18 -0.3 4.45e-7 Psoriasis; CESC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg05585544 chr11:47624801 NA -0.47 -6.91 -0.39 3.5e-11 Subjective well-being; CESC cis rs6964587 0.869 rs34791781 chr7:91532720 C/T cg17063962 chr7:91808500 NA -0.53 -6.95 -0.39 2.88e-11 Breast cancer; CESC cis rs9640161 0.789 rs60283368 chr7:150023258 G/A cg13722127 chr7:150037890 RARRES2 0.33 5.07 0.3 7.38e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs1707322 0.752 rs28545085 chr1:46201950 G/A cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9837602 0.938 rs34922392 chr3:99794730 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.45 6.3 0.36 1.2e-9 Breast cancer; CESC cis rs1018836 0.923 rs9694450 chr8:91618292 G/A cg16814680 chr8:91681699 NA -0.75 -10.9 -0.56 4.28e-23 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs1707322 1.000 rs4606257 chr1:46307268 G/A cg03146154 chr1:46216737 IPP 0.78 10.67 0.55 2.45e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9649213 0.533 rs1541409 chr7:98027580 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.44 -5.86 -0.34 1.37e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg17211192 chr8:82754475 SNX16 0.51 6.63 0.38 1.89e-10 Diastolic blood pressure; CESC trans rs73198271 0.653 rs10087742 chr8:8660474 A/G cg23754772 chr18:12253859 CIDEA -0.33 -6.01 -0.35 6.07e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg05863683 chr7:1912471 MAD1L1 0.4 5.91 0.34 1.07e-8 Bipolar disorder and schizophrenia; CESC cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg26597838 chr10:835615 NA 0.8 9.43 0.5 2.09e-18 Eosinophil percentage of granulocytes; CESC cis rs17376456 0.877 rs10060160 chr5:93387879 G/A cg25358565 chr5:93447407 FAM172A 1.14 10.64 0.55 2.97e-22 Diabetic retinopathy; CESC cis rs2072732 0.861 rs12044848 chr1:2960790 C/T cg15211996 chr1:2936768 ACTRT2 0.35 5.87 0.34 1.31e-8 Plateletcrit; CESC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 11.52 0.58 3.59e-25 Platelet count; CESC cis rs2230307 0.536 rs575971 chr1:100546591 T/C cg24955406 chr1:100503596 HIAT1 0.53 5.25 0.31 3.18e-7 Carotid intima media thickness; CESC cis rs2415984 0.622 rs1761029 chr14:46934764 T/C cg14871534 chr14:47121158 RPL10L 0.35 5.36 0.31 1.82e-7 Number of children ever born; CESC cis rs7208859 0.623 rs2035494 chr17:29130393 T/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg09177884 chr7:1199841 ZFAND2A -0.56 -6.29 -0.36 1.29e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg00684032 chr4:1343700 KIAA1530 0.4 5.56 0.32 6.51e-8 Obesity-related traits; CESC cis rs6693567 0.545 rs7411534 chr1:150447269 C/T cg09579323 chr1:150459698 TARS2 0.44 5.65 0.33 4.12e-8 Migraine; CESC cis rs2760061 0.583 rs708121 chr1:228208257 A/G cg02753203 chr1:228287806 NA 0.8 11.29 0.57 2.17e-24 Diastolic blood pressure; CESC cis rs3733585 0.699 rs62294332 chr4:9959989 T/C cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg07395648 chr5:131743802 NA -0.44 -5.72 -0.33 2.95e-8 Breast cancer; CESC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 6.3 0.36 1.2e-9 LDL cholesterol;Cholesterol, total; CESC cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg04450456 chr4:17643702 FAM184B 0.36 5.13 0.3 5.72e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7223966 1.000 rs8068603 chr17:61755211 T/A cg11494091 chr17:61959527 GH2 0.38 5.35 0.31 1.93e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg26304593 chr6:42947056 PEX6 -0.43 -5.5 -0.32 8.76e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs3106136 0.586 rs72663785 chr4:95069794 C/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -5.08 -0.3 7.11e-7 Capecitabine sensitivity; CESC cis rs12973672 1.000 rs34832786 chr19:35769518 T/C cg12095397 chr19:35769544 USF2 0.54 7.35 0.41 2.49e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg06028808 chr11:68637592 NA 0.44 5.24 0.31 3.2e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4718428 0.705 rs4717331 chr7:66378886 C/T cg25985355 chr7:65971099 NA -0.36 -5.35 -0.31 1.94e-7 Corneal structure; CESC cis rs77106637 0.932 rs17244499 chr11:72629946 C/T cg03713592 chr11:72463424 ARAP1 -1.08 -9.66 -0.51 4.03e-19 Type 2 diabetes; CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg14159672 chr1:205819179 PM20D1 -0.7 -11.41 -0.57 8.82e-25 Monocyte percentage of white cells; CESC cis rs7520050 1.000 rs12143096 chr1:46469763 G/A cg24296786 chr1:45957014 TESK2 0.44 5.5 0.32 9.17e-8 Red blood cell count;Reticulocyte count; CESC cis rs12541635 0.966 rs34177605 chr8:107065105 G/A cg10147462 chr8:107024639 NA 0.37 5.16 0.3 4.74e-7 Age of smoking initiation; CESC cis rs6723226 0.882 rs13035097 chr2:32836362 A/G cg02381751 chr2:32503542 YIPF4 -0.69 -8.88 -0.48 1.04e-16 Intelligence (multi-trait analysis); CESC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg17724175 chr1:150552817 MCL1 0.4 6.14 0.35 2.98e-9 Melanoma; CESC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg02038168 chr22:39784481 NA -0.61 -7.47 -0.42 1.13e-12 Intelligence (multi-trait analysis); CESC cis rs79057730 0.599 rs34411410 chr7:811721 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.91 7.83 0.43 1.19e-13 Initial pursuit acceleration; CESC cis rs2290159 0.747 rs6777175 chr3:12646255 A/T cg23032965 chr3:12705835 RAF1 0.51 5.63 0.33 4.48e-8 Cholesterol, total; CESC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg04414720 chr1:150670196 GOLPH3L 0.55 7.19 0.4 6.44e-12 Melanoma; CESC cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg05343316 chr1:45956843 TESK2 -0.51 -6.75 -0.38 9.56e-11 High light scatter reticulocyte count; CESC cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.29 0.45 5.87e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1538970 0.924 rs6657284 chr1:45879088 T/C cg06784218 chr1:46089804 CCDC17 0.33 5.49 0.32 9.28e-8 Platelet count; CESC cis rs763121 0.853 rs2072796 chr22:39064230 A/G cg14440974 chr22:39074834 NA -0.42 -5.82 -0.34 1.69e-8 Menopause (age at onset); CESC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.48 0.42 1.1e-12 Tonsillectomy; CESC cis rs2760061 0.717 rs708117 chr1:228199902 G/A cg18477163 chr1:228402036 OBSCN 0.32 5.69 0.33 3.3e-8 Diastolic blood pressure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16025584 chr9:139887217 C9orf142 0.5 6.61 0.38 2.07e-10 Gut microbiota (bacterial taxa); CESC cis rs2120019 1.000 rs2415253 chr15:75375699 A/G cg09165964 chr15:75287851 SCAMP5 -0.69 -8.37 -0.46 3.42e-15 Blood trace element (Zn levels); CESC cis rs4481887 1.000 rs4457616 chr1:248492198 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.68 0.38 1.42e-10 Common traits (Other); CESC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg00106254 chr7:1943704 MAD1L1 0.43 5.31 0.31 2.37e-7 Bipolar disorder and schizophrenia; CESC cis rs7927771 0.524 rs10838782 chr11:47877800 A/G cg18512352 chr11:47633146 NA 0.35 5.35 0.31 1.87e-7 Subjective well-being; CESC trans rs11971186 0.662 rs1204529 chr7:126515801 T/C cg10894441 chr11:111169905 C11orf92;C11orf93 -0.52 -6.67 -0.38 1.49e-10 Chemerin levels; CESC cis rs9788682 1.000 rs7181447 chr15:78814567 A/G cg06917634 chr15:78832804 PSMA4 -0.56 -6.64 -0.38 1.72e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg17971929 chr21:40555470 PSMG1 -0.87 -12.78 -0.62 1.78e-29 Cognitive function; CESC cis rs2742234 1.000 rs2742234 chr10:43612609 A/G cg07801480 chr10:43725741 RASGEF1A -0.39 -5.55 -0.32 6.85e-8 Hirschsprung disease; CESC cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg02079420 chr8:82753780 SNX16 0.57 7.65 0.43 3.81e-13 Diastolic blood pressure; CESC cis rs7560272 0.501 rs11891140 chr2:73944084 A/G cg20560298 chr2:73613845 ALMS1 0.41 5.69 0.33 3.43e-8 Schizophrenia; CESC cis rs4253772 0.938 rs41427746 chr22:46637239 T/C cg09491104 chr22:46646882 C22orf40 -0.51 -6.54 -0.37 3.24e-10 LDL cholesterol;Cholesterol, total; CESC cis rs7116495 1.000 rs642573 chr11:71780854 G/C cg10381502 chr11:71823885 C11orf51 -0.61 -5.13 -0.3 5.6e-7 Severe influenza A (H1N1) infection; CESC cis rs2243480 1.000 rs410128 chr7:65603173 C/T cg13147721 chr7:65941812 NA -0.98 -9.03 -0.48 3.72e-17 Diabetic kidney disease; CESC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.87 0.62 9.38e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 0.708 rs35825036 chr7:65986502 T/C cg18252515 chr7:66147081 NA -1.4 -14.3 -0.66 9.38e-35 Diabetic kidney disease; CESC cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.48 -6.46 -0.37 5.03e-10 Personality dimensions; CESC cis rs1256061 0.564 rs1256043 chr14:64734282 A/G cg21174375 chr14:64681225 SYNE2 0.51 6.82 0.39 6.15e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2276314 0.857 rs28396546 chr18:33639024 T/C cg05985134 chr18:33552581 C18orf21 0.62 7.16 0.4 8.06e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg22800045 chr5:56110881 MAP3K1 0.74 9.18 0.49 1.3e-17 Initial pursuit acceleration; CESC cis rs9303401 0.659 rs62083525 chr17:56658088 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.56e-29 Cognitive test performance; CESC cis rs2797160 0.651 rs1268066 chr6:126035041 C/T cg05901451 chr6:126070800 HEY2 0.52 7.49 0.42 1.04e-12 Endometrial cancer; CESC cis rs9611565 0.559 rs12483860 chr22:41961916 C/T cg17376030 chr22:41985996 PMM1 0.53 5.88 0.34 1.25e-8 Vitiligo; CESC cis rs8014204 0.868 rs2230237 chr14:75359670 G/A cg26191576 chr14:75389716 RPS6KL1 0.36 5.17 0.3 4.61e-7 Caffeine consumption; CESC cis rs2414059 0.518 rs2289108 chr15:50782335 G/A cg05456662 chr15:50716270 USP8 -0.4 -5.22 -0.31 3.69e-7 QT interval; CESC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.52 -6.94 -0.39 2.93e-11 Menarche (age at onset); CESC cis rs9486715 0.867 rs9373829 chr6:96897201 A/C cg18709589 chr6:96969512 KIAA0776 -0.41 -5.77 -0.33 2.16e-8 Headache; CESC cis rs501120 1.000 rs552794 chr10:44771666 G/A cg09554077 chr10:44749378 NA 0.52 6.94 0.39 3.05e-11 Coronary artery disease;Coronary heart disease; CESC cis rs17253792 0.822 rs76472022 chr14:56053660 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.66 0.33 3.95e-8 Putamen volume; CESC cis rs12477438 0.765 rs7605734 chr2:99644068 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02631680 chr6:44094852 TMEM63B;MRPL14 -0.46 -6.38 -0.36 7.69e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2652822 0.509 rs6494394 chr15:63440938 A/G cg02713581 chr15:63449717 RPS27L 0.47 5.51 0.32 8.36e-8 Metabolic traits; CESC cis rs6570726 0.902 rs406979 chr6:145838983 G/T cg23711669 chr6:146136114 FBXO30 0.78 11.62 0.58 1.64e-25 Lobe attachment (rater-scored or self-reported); CESC trans rs2727020 0.554 rs2866490 chr11:49425463 A/G cg15704280 chr7:45808275 SEPT13 -0.81 -9.53 -0.51 1.04e-18 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19643035 chr5:177022360 TMED9 -0.55 -6.28 -0.36 1.39e-9 Gut microbiome composition (summer); CESC cis rs752010 0.714 rs7552928 chr1:42086664 C/T cg06885757 chr1:42089581 HIVEP3 0.51 8.84 0.48 1.39e-16 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18304472 chr19:45844176 KLC3 0.57 6.52 0.37 3.49e-10 Gut microbiome composition (summer); CESC cis rs11583043 1.000 rs6660290 chr1:101483512 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.47 -5.22 -0.31 3.58e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs2637266 1.000 rs10219107 chr10:78364369 T/C cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs9611565 0.649 rs4822050 chr22:42177453 C/G cg03806693 chr22:41940476 POLR3H -0.68 -7.85 -0.43 1.07e-13 Vitiligo; CESC cis rs2425143 1.000 rs11699690 chr20:34271774 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -7.53 -0.42 8.04e-13 Blood protein levels; CESC cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg10523679 chr1:76189770 ACADM -0.77 -10.6 -0.55 4.2e-22 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11690935 1.000 rs6757773 chr2:172549630 T/A cg13550731 chr2:172543902 DYNC1I2 1.0 16.64 0.71 4.76e-43 Schizophrenia; CESC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.33 -0.31 2.06e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg18876405 chr7:65276391 NA 0.5 5.91 0.34 1.05e-8 Aortic root size; CESC cis rs727505 1.000 rs3925331 chr7:124446137 C/G cg23710748 chr7:124431027 NA -0.38 -6.11 -0.35 3.48e-9 Lewy body disease; CESC cis rs2637266 0.663 rs846581 chr10:78497984 C/T cg18941641 chr10:78392320 NA 0.43 8.46 0.46 1.81e-15 Pulmonary function; CESC cis rs459571 1.000 rs456207 chr9:136911140 G/A cg13789015 chr9:136890014 NCRNA00094 0.52 7.56 0.42 6.52e-13 Platelet distribution width; CESC cis rs34779708 0.733 rs60553075 chr10:35542462 T/A cg04310649 chr10:35416472 CREM -0.47 -5.39 -0.31 1.59e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs2262909 0.962 rs436662 chr19:22232107 C/T cg11619707 chr19:22235551 ZNF257 -0.32 -5.26 -0.31 2.94e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16828585 chr10:8051100 TAF3 0.46 6.02 0.35 5.9e-9 Fibrinogen levels; CESC cis rs8018808 0.935 rs12436593 chr14:77928476 C/T cg20045696 chr14:77926864 AHSA1 0.41 5.74 0.33 2.54e-8 Myeloid white cell count; CESC cis rs7945705 0.935 rs11042103 chr11:8888700 C/T cg12365402 chr11:9010492 NRIP3 0.35 5.45 0.32 1.16e-7 Hemoglobin concentration; CESC cis rs2228479 0.557 rs57071566 chr16:89889327 T/G cg06558623 chr16:89946397 TCF25 0.99 7.42 0.41 1.62e-12 Skin colour saturation; CESC cis rs1005277 0.522 rs11011343 chr10:38002698 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -7.13 -0.4 9.74e-12 Extrinsic epigenetic age acceleration; CESC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg13206674 chr6:150067644 NUP43 0.43 5.89 0.34 1.18e-8 Lung cancer; CESC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg03351412 chr1:154909251 PMVK 0.59 7.8 0.43 1.46e-13 Prostate cancer; CESC cis rs9322193 0.566 rs3922947 chr6:150245992 G/A cg01145232 chr6:150245071 RAET1G -0.51 -6.63 -0.38 1.86e-10 Lung cancer; CESC cis rs9287719 0.967 rs11674433 chr2:10730839 T/C cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.35e-8 Prostate cancer; CESC cis rs1371867 0.875 rs1788176 chr8:101332112 A/G cg11906718 chr8:101322791 RNF19A 0.53 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC cis rs6088590 1.000 rs2180276 chr20:33360785 T/A cg06115741 chr20:33292138 TP53INP2 0.59 7.35 0.41 2.41e-12 Coronary artery disease; CESC cis rs28489187 0.617 rs233133 chr1:85796557 G/T cg16011679 chr1:85725395 C1orf52 0.46 5.45 0.32 1.12e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs8049040 0.500 rs7188475 chr16:71446358 C/T cg08717414 chr16:71523259 ZNF19 -0.5 -5.75 -0.33 2.44e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06604058 chr11:63448992 RTN3 0.55 6.61 0.38 2.15e-10 Gut microbiome composition (summer); CESC cis rs1559088 0.573 rs1270591 chr19:33622942 C/T cg17764715 chr19:33622953 WDR88 -0.6 -8.57 -0.47 8.82e-16 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01989157 chr22:40742702 ADSL -0.47 -6.38 -0.36 7.82e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11809207 0.523 rs2186232 chr1:26502676 T/A cg00147160 chr1:26503991 CNKSR1 0.29 5.52 0.32 8.08e-8 Height; CESC cis rs7577696 0.524 rs212696 chr2:32441685 A/G cg02381751 chr2:32503542 YIPF4 0.48 5.44 0.32 1.18e-7 Inflammatory biomarkers; CESC cis rs6582630 0.519 rs11519914 chr12:38287014 A/G cg13010199 chr12:38710504 ALG10B 0.4 5.13 0.3 5.54e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs4595586 0.545 rs1562728 chr12:39405740 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs7267979 1.000 rs2500432 chr20:25290512 A/C cg08601574 chr20:25228251 PYGB 0.39 5.69 0.33 3.39e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg15369054 chr17:80825471 TBCD 0.53 7.07 0.4 1.41e-11 Breast cancer; CESC cis rs5753618 0.504 rs5753671 chr22:31910734 T/C cg02404636 chr22:31891804 SFI1 0.43 5.96 0.34 7.98e-9 Colorectal cancer; CESC cis rs672059 0.967 rs657901 chr1:183163411 T/G ch.1.3577855R chr1:183094577 LAMC1 0.56 7.2 0.4 6.39e-12 Hypertriglyceridemia; CESC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.89 0.44 8.1e-14 Menopause (age at onset); CESC cis rs4727963 0.846 rs1525485 chr7:122702653 G/A cg03640110 chr7:122635026 TAS2R16 -0.37 -5.7 -0.33 3.11e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg08888203 chr3:10149979 C3orf24 0.49 6.14 0.35 3.07e-9 Alzheimer's disease; CESC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.64 -0.33 4.28e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9457247 1.000 rs402749 chr6:167386104 C/T cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC cis rs7267979 1.000 rs6107033 chr20:25363591 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -17.13 -0.72 8.57e-45 Liver enzyme levels (alkaline phosphatase); CESC trans rs57221529 0.766 rs4245972 chr5:578572 A/G cg25482853 chr8:67687455 SGK3 1.01 10.17 0.53 9.74e-21 Lung disease severity in cystic fibrosis; CESC trans rs7246760 0.867 rs66927855 chr19:9811728 C/T cg02900749 chr2:68251473 NA -0.82 -7.26 -0.41 4.38e-12 Pursuit maintenance gain; CESC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.37 -0.31 1.76e-7 Life satisfaction; CESC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.04 0.3 8.7e-7 Menopause (age at onset); CESC cis rs2249694 0.960 rs7094588 chr10:135401586 A/G cg20169779 chr10:135381914 SYCE1 -0.4 -5.81 -0.34 1.76e-8 Obesity-related traits; CESC cis rs79387448 0.701 rs76943877 chr2:102970677 T/C cg09003973 chr2:102972529 NA 1.2 9.29 0.5 6.03e-18 Gut microbiota (bacterial taxa); CESC cis rs67366981 0.720 rs4447349 chr14:77685381 G/A cg22824376 chr14:77648248 TMEM63C 0.78 7.51 0.42 9.21e-13 Obsessive-compulsive symptoms; CESC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs929354 0.772 rs2023977 chr7:156996022 C/G cg05182265 chr7:156933206 UBE3C -0.51 -7.47 -0.42 1.2e-12 Body mass index; CESC trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21659725 chr3:3221576 CRBN 0.81 12.35 0.6 5.71e-28 Intelligence (multi-trait analysis); CESC cis rs1008375 1.000 rs2315560 chr4:17677305 C/G cg02297831 chr4:17616191 MED28 0.45 5.64 0.33 4.42e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2617583 0.967 rs2550946 chr5:1450513 A/G cg07151155 chr5:1473589 LPCAT1 -0.36 -5.52 -0.32 7.95e-8 Breast cancer; CESC cis rs7980687 0.527 rs1727295 chr12:123616861 G/A cg00376283 chr12:123451042 ABCB9 0.71 9.87 0.52 9.06e-20 Height;Educational attainment;Head circumference (infant); CESC cis rs3768617 0.706 rs10797801 chr1:182971965 G/T ch.1.3577855R chr1:183094577 LAMC1 0.69 9.92 0.52 6.42e-20 Fuchs's corneal dystrophy; CESC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg23161317 chr6:28129485 ZNF389 0.49 6.19 0.36 2.28e-9 Parkinson's disease; CESC cis rs2404602 0.575 rs11633309 chr15:76962349 C/A cg00316803 chr15:76480434 C15orf27 0.43 5.91 0.34 1.05e-8 Blood metabolite levels; CESC trans rs2415984 0.811 rs7157724 chr14:46854443 G/T cg14945696 chr3:52713679 PBRM1 -0.39 -6.05 -0.35 4.98e-9 Number of children ever born; CESC cis rs7666738 0.830 rs34892904 chr4:98938097 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.866 rs6847778 chr4:120293582 A/G cg24375607 chr4:120327624 NA 0.42 5.15 0.3 5.21e-7 Corneal astigmatism; CESC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg18230493 chr5:56204884 C5orf35 -0.58 -7.81 -0.43 1.38e-13 Coronary artery disease; CESC cis rs881375 0.967 rs10733648 chr9:123700779 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.41 5.52 0.32 7.97e-8 Rheumatoid arthritis; CESC cis rs10503871 0.690 rs7812836 chr8:30352258 A/G cg26383811 chr8:30366931 RBPMS -0.37 -5.08 -0.3 7.25e-7 Metabolite levels (X-11787); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06296570 chr7:130792605 FLJ43663 -0.52 -6.08 -0.35 4.09e-9 Gut microbiome composition (summer); CESC cis rs7264396 0.635 rs6058355 chr20:34491343 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.59 7.2 0.4 6.2e-12 Total cholesterol levels; CESC cis rs1009170 0.794 rs58036446 chr14:92590192 A/C cg10324096 chr14:92587714 CPSF2;NDUFB1 0.55 5.17 0.3 4.73e-7 Dialysis-related mortality; CESC cis rs11608355 0.521 rs7976839 chr12:109830534 C/A cg19025524 chr12:109796872 NA -0.54 -7.7 -0.43 2.8e-13 Neuroticism; CESC cis rs6460942 0.597 rs17544637 chr7:12521871 T/C cg02935154 chr7:12443704 VWDE -0.48 -5.09 -0.3 6.85e-7 Coronary artery disease; CESC cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg09455208 chr3:40491958 NA 0.51 8.53 0.46 1.11e-15 Renal cell carcinoma; CESC cis rs1348850 0.632 rs12467363 chr2:178502512 C/T cg22681709 chr2:178499509 PDE11A -0.57 -8.82 -0.48 1.52e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4664308 0.905 rs62177860 chr2:160960571 C/T cg03641300 chr2:160917029 PLA2R1 -0.66 -9.7 -0.51 3.12e-19 Idiopathic membranous nephropathy; CESC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC cis rs7927592 0.763 rs4340059 chr11:68362433 A/G cg20283391 chr11:68216788 NA -0.42 -5.17 -0.3 4.58e-7 Total body bone mineral density; CESC cis rs9807841 0.500 rs1368459 chr19:10835338 C/G cg17710535 chr19:10819994 QTRT1 0.42 6.01 0.35 6.16e-9 Inflammatory skin disease; CESC cis rs5747327 0.839 rs7291752 chr22:18180911 T/C cg19898043 chr22:18121309 BCL2L13 -0.4 -5.19 -0.3 4.18e-7 Myeloid white cell count;Granulocyte count; CESC cis rs798554 0.655 rs798492 chr7:2799184 C/T cg19717773 chr7:2847554 GNA12 0.51 8.11 0.45 1.95e-14 Height; CESC cis rs1577917 0.916 rs12198730 chr6:86555138 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.18 -0.36 2.36e-9 Response to antipsychotic treatment; CESC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg03452623 chr4:187889614 NA -0.89 -15.84 -0.7 3.13e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs11190604 1.000 rs10786596 chr10:102282126 C/A cg07080220 chr10:102295463 HIF1AN 0.6 5.84 0.34 1.56e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07953307 chr16:29000920 LAT -0.65 -7.31 -0.41 3.11e-12 Gut microbiome composition (summer); CESC cis rs7590368 0.926 rs12623588 chr2:10957612 C/G cg15705551 chr2:10952987 PDIA6 -0.52 -5.96 -0.34 7.97e-9 Educational attainment (years of education); CESC cis rs67311347 1.000 rs56992941 chr3:40472434 A/T cg24209194 chr3:40518798 ZNF619 0.5 6.63 0.38 1.85e-10 Renal cell carcinoma; CESC cis rs7216064 1.000 rs3206817 chr17:65892834 A/G cg12091567 chr17:66097778 LOC651250 -0.78 -8.09 -0.45 2.1e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6750795 0.518 rs1434519 chr2:232433761 A/G cg19187155 chr2:232395269 NMUR1 0.49 5.98 0.34 7.24e-9 Height; CESC cis rs2072499 0.778 rs2247476 chr1:156190280 C/A cg25208724 chr1:156163844 SLC25A44 0.91 11.42 0.57 8.02e-25 Testicular germ cell tumor; CESC cis rs2304069 0.545 rs6866616 chr5:149415401 A/G cg12661370 chr5:149340060 SLC26A2 0.46 6.11 0.35 3.46e-9 HIV-1 control; CESC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC cis rs7208859 0.623 rs1061346 chr17:29114229 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs847577 0.748 rs940432 chr7:97716483 G/A cg24562669 chr7:97807699 LMTK2 0.63 10.15 0.53 1.13e-20 Breast cancer; CESC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg20744362 chr22:50050164 C22orf34 0.46 8.09 0.44 2.2e-14 Monocyte count;Monocyte percentage of white cells; CESC cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -8.36 -0.46 3.59e-15 Hemoglobin concentration; CESC cis rs6540559 0.546 rs634601 chr1:210421594 C/T cg21951975 chr1:209979733 IRF6 0.46 6.2 0.36 2.16e-9 Cleft lip with or without cleft palate; CESC cis rs910316 1.000 rs7142235 chr14:75559963 T/C cg08847533 chr14:75593920 NEK9 1.01 19.43 0.77 6.73e-53 Height; CESC cis rs1878931 0.615 rs6501171 chr16:3402610 T/A cg22508957 chr16:3507546 NAT15 -0.36 -5.08 -0.3 7.05e-7 Body mass index (adult); CESC cis rs853679 0.546 rs13214023 chr6:28332141 A/G cg18032046 chr6:28092343 ZSCAN16 0.66 5.23 0.31 3.52e-7 Depression; CESC cis rs12545109 0.613 rs4541914 chr8:57254555 T/G cg09654669 chr8:57350985 NA -0.56 -6.17 -0.35 2.48e-9 Obesity-related traits; CESC cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg05234568 chr11:5960015 NA -0.56 -6.54 -0.37 3.15e-10 DNA methylation (variation); CESC cis rs2412488 0.853 rs6818788 chr4:54356173 C/T cg22241045 chr4:54363911 LNX1 -0.38 -5.32 -0.31 2.19e-7 DNA methylation (variation); CESC cis rs2742234 0.590 rs2503848 chr10:43672785 G/A cg15436174 chr10:43711423 RASGEF1A -0.5 -5.76 -0.33 2.34e-8 Hirschsprung disease; CESC cis rs57244997 0.685 rs1954916 chr6:162447612 A/G cg17173639 chr6:162384350 PARK2 -0.58 -6.11 -0.35 3.53e-9 Mosquito bite size; CESC cis rs6828523 0.698 rs75086254 chr4:175851520 T/G cg14561282 chr4:175839468 ADAM29 0.44 5.05 0.3 8.12e-7 Breast cancer; CESC cis rs79057730 0.639 rs6463933 chr7:793954 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.65 5.62 0.33 4.8e-8 Initial pursuit acceleration; CESC cis rs6460942 1.000 rs6460938 chr7:12406808 T/G cg10578991 chr7:12443926 VWDE -0.53 -5.69 -0.33 3.32e-8 Coronary artery disease; CESC cis rs7188697 0.743 rs11859781 chr16:58602589 T/A cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg22974920 chr21:40686053 BRWD1 -0.46 -5.72 -0.33 2.9e-8 Cognitive function; CESC cis rs10479542 0.503 rs12719865 chr5:178993566 C/T cg09060608 chr5:178986726 RUFY1 0.52 7.75 0.43 1.97e-13 Lung cancer; CESC cis rs66887589 0.720 rs2036858 chr4:120249237 A/C cg09307838 chr4:120376055 NA 0.56 7.54 0.42 7.59e-13 Diastolic blood pressure; CESC cis rs6460942 0.505 rs73290446 chr7:12358133 T/G cg06484146 chr7:12443880 VWDE -0.6 -6.44 -0.37 5.7e-10 Coronary artery disease; CESC trans rs12615721 0.892 rs34426147 chr2:81957166 T/C cg13174197 chr3:52720522 GNL3;PBRM1 0.78 6.24 0.36 1.77e-9 Pulmonary function decline; CESC cis rs2228479 0.681 rs10153055 chr16:89965842 C/T cg00800038 chr16:89945340 TCF25 -0.6 -6.48 -0.37 4.56e-10 Skin colour saturation; CESC cis rs7582720 1.000 rs72926767 chr2:203796814 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg01341218 chr17:43662625 NA 0.55 6.62 0.38 1.94e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs1814175 0.645 rs12364337 chr11:49942580 A/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs9300255 0.739 rs1533703 chr12:123742093 T/G cg00376283 chr12:123451042 ABCB9 0.7 8.63 0.47 5.59e-16 Neutrophil percentage of white cells; CESC cis rs11098499 0.866 rs3756156 chr4:120524841 G/A cg24375607 chr4:120327624 NA 0.43 5.28 0.31 2.66e-7 Corneal astigmatism; CESC cis rs4820539 0.641 rs5759602 chr22:23489362 C/T cg14186256 chr22:23484241 RTDR1 -0.72 -10.79 -0.55 1.01e-22 Bone mineral density; CESC cis rs9488822 0.676 rs11757115 chr6:116362619 C/T cg05304507 chr6:116381966 FRK 0.26 6.6 0.38 2.24e-10 Cholesterol, total;LDL cholesterol; CESC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 9.61 0.51 6.02e-19 Platelet count; CESC cis rs1580019 0.844 rs4723159 chr7:32512804 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.43 5.13 0.3 5.72e-7 Cognitive ability; CESC cis rs36051895 0.589 rs10491651 chr9:5200060 A/G cg02405213 chr9:5042618 JAK2 -0.5 -5.85 -0.34 1.46e-8 Pediatric autoimmune diseases; CESC cis rs2832191 1.000 rs2832185 chr21:30483761 C/G cg08807101 chr21:30365312 RNF160 -0.65 -8.88 -0.48 1.03e-16 Dental caries; CESC cis rs35146811 0.961 rs35991721 chr7:99728790 G/T cg22906224 chr7:99728672 NA 0.46 5.17 0.3 4.51e-7 Coronary artery disease; CESC cis rs1847202 0.859 rs4490296 chr3:72949197 C/A cg25664220 chr3:72788482 NA -0.37 -5.44 -0.32 1.2e-7 Motion sickness; CESC cis rs3820068 0.581 rs16851855 chr1:15930869 G/A cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs4566357 0.615 rs10177528 chr2:227913706 G/A cg11843606 chr2:227700838 RHBDD1 -0.5 -6.82 -0.39 6.08e-11 Coronary artery disease; CESC cis rs3733585 0.673 rs7672947 chr4:9961368 G/C cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.49 7.0 0.39 2.11e-11 Menopause (age at onset); CESC cis rs9457247 0.624 rs17524252 chr6:167466978 T/G cg23791538 chr6:167370224 RNASET2 -0.52 -6.87 -0.39 4.45e-11 Crohn's disease; CESC cis rs67340775 0.541 rs200973 chr6:27858421 A/G cg17221315 chr6:27791827 HIST1H4J 0.55 5.35 0.31 1.93e-7 Lung cancer in ever smokers; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00597055 chr15:41523239 CHP;EXD1 -0.46 -6.34 -0.36 1.01e-9 Gut microbiota (bacterial taxa); CESC cis rs2797160 0.522 rs6925158 chr6:125940188 T/G cg05901451 chr6:126070800 HEY2 -0.39 -5.27 -0.31 2.87e-7 Endometrial cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06982628 chr22:38597918 MAFF 0.56 6.15 0.35 2.83e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13379827 chr1:65468782 NA -0.55 -7.1 -0.4 1.13e-11 Ulcerative colitis; CESC cis rs1800469 1.000 rs1549933 chr19:41871142 A/G cg09537434 chr19:41945824 ATP5SL -0.67 -8.31 -0.45 5.12e-15 Colorectal cancer; CESC cis rs2228479 0.702 rs11649501 chr16:89850957 A/T cg14709524 chr16:89940631 TCF25 0.94 7.05 0.4 1.57e-11 Skin colour saturation; CESC cis rs2243480 1.000 rs34577383 chr7:65385726 C/T cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg02725872 chr8:58115012 NA 0.45 7.12 0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg23583168 chr7:148888333 NA -0.71 -9.51 -0.5 1.26e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs7726839 0.540 rs11750321 chr5:599196 C/T cg25482853 chr8:67687455 SGK3 1.04 10.14 0.53 1.27e-20 Obesity-related traits; CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg15112475 chr7:1198522 ZFAND2A -0.44 -7.11 -0.4 1.06e-11 Longevity;Endometriosis; CESC trans rs3780486 0.846 rs3780487 chr9:33139237 T/C cg04842962 chr6:43655489 MRPS18A 1.01 19.75 0.77 5.15e-54 IgG glycosylation; CESC cis rs5758659 0.714 rs133376 chr22:42466905 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.34 -5.73 -0.33 2.71e-8 Cognitive function; CESC cis rs7560272 0.538 rs17350056 chr2:73922877 G/A cg20560298 chr2:73613845 ALMS1 0.46 6.23 0.36 1.87e-9 Schizophrenia; CESC cis rs1691799 0.899 rs1185244 chr12:66725160 C/T cg16791601 chr12:66731901 HELB -0.73 -12.46 -0.61 2.25e-28 White blood cell count (basophil); CESC cis rs12956009 0.583 rs4331415 chr18:44885048 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.78 0.38 8e-11 Educational attainment (years of education); CESC cis rs78707713 0.560 rs17569412 chr10:71237536 C/A cg12610070 chr10:71211762 TSPAN15 -0.33 -6.85 -0.39 5.18e-11 Venous thromboembolism; CESC cis rs4253772 0.550 rs6007761 chr22:46670394 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.65 -7.85 -0.43 1.06e-13 LDL cholesterol;Cholesterol, total; CESC cis rs6543140 0.964 rs10200081 chr2:103091556 T/C cg04239558 chr2:103089729 SLC9A4 0.48 6.28 0.36 1.35e-9 Blood protein levels; CESC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.64 6.46 0.37 4.99e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs9911578 1.000 rs1057068 chr17:56598439 T/C cg05425664 chr17:57184151 TRIM37 0.49 6.82 0.39 6.17e-11 Intelligence (multi-trait analysis); CESC cis rs6456156 0.524 rs6934043 chr6:167466449 C/T cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.13e-10 Primary biliary cholangitis; CESC cis rs936229 0.749 rs6495127 chr15:75194490 C/T cg10253484 chr15:75165896 SCAMP2 -0.45 -5.12 -0.3 5.98e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg26769984 chr7:1090371 C7orf50 0.48 5.09 0.3 6.85e-7 Bronchopulmonary dysplasia; CESC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg04287289 chr16:89883240 FANCA 0.88 14.99 0.68 3.3e-37 Vitiligo; CESC cis rs7818688 1.000 rs28651964 chr8:96026781 C/T cg16049864 chr8:95962084 TP53INP1 0.61 5.74 0.33 2.62e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg16405210 chr4:1374714 KIAA1530 -0.53 -7.09 -0.4 1.25e-11 Longevity; CESC cis rs7605827 0.930 rs13004154 chr2:15664325 A/G cg19274914 chr2:15703543 NA 0.3 5.26 0.31 2.96e-7 Educational attainment (years of education); CESC cis rs13720 0.915 rs163782 chr20:57565943 G/C cg23907860 chr20:57583709 CTSZ -0.45 -5.41 -0.32 1.44e-7 Platelet distribution width; CESC cis rs10911363 0.592 rs10911354 chr1:183489278 G/A cg09173681 chr1:183549694 NCF2 0.53 7.81 0.43 1.3e-13 Systemic lupus erythematosus; CESC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.56 6.79 0.38 7.43e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7208859 0.623 rs11658945 chr17:29122509 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7542091 0.704 rs7550330 chr1:210044587 G/A cg22029157 chr1:209979665 IRF6 0.5 7.98 0.44 4.32e-14 Monobrow; CESC cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg05347473 chr6:146136440 FBXO30 -0.52 -6.72 -0.38 1.1e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg00149659 chr3:10157352 C3orf10 0.73 8.54 0.46 1.05e-15 Alzheimer's disease; CESC cis rs7917772 0.503 rs7902306 chr10:104290462 C/T cg22532475 chr10:104410764 TRIM8 -0.31 -5.12 -0.3 5.75e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg06212747 chr3:49208901 KLHDC8B 0.67 8.99 0.48 4.66e-17 Parkinson's disease; CESC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg11764359 chr7:65958608 NA -0.78 -11.64 -0.58 1.47e-25 Aortic root size; CESC cis rs2952156 0.920 rs2517958 chr17:37838751 G/A cg07936489 chr17:37558343 FBXL20 -0.6 -7.77 -0.43 1.77e-13 Asthma; CESC cis rs6460942 1.000 rs112794590 chr7:12319426 G/A cg10578991 chr7:12443926 VWDE -0.61 -6.41 -0.37 6.66e-10 Coronary artery disease; CESC cis rs2832191 0.967 rs1999321 chr21:30530233 A/C cg24692254 chr21:30365293 RNF160 0.73 10.75 0.55 1.34e-22 Dental caries; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23296408 chr14:91580613 C14orf159 -0.57 -6.38 -0.36 8.04e-10 Gut microbiome composition (summer); CESC cis rs8141529 0.644 rs5752795 chr22:29178820 T/C cg15103426 chr22:29168792 CCDC117 0.7 9.85 0.52 1.06e-19 Lymphocyte counts; CESC cis rs6076065 0.748 rs2180139 chr20:23405281 G/A cg11657817 chr20:23433608 CST11 0.41 6.09 0.35 4.04e-9 Facial morphology (factor 15, philtrum width); CESC cis rs7572263 0.724 rs11676550 chr2:209053775 T/C cg23998903 chr2:209048830 C2orf80 -0.39 -5.14 -0.3 5.4e-7 Glioma;Non-glioblastoma glioma; CESC cis rs12190007 1.000 rs12190007 chr6:169727601 C/T cg16388071 chr6:169726476 NA -0.46 -6.29 -0.36 1.33e-9 Obesity-related traits; CESC cis rs977987 0.806 rs4888390 chr16:75400320 G/A cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.73e-8 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04048411 chr12:94541943 PLXNC1 0.5 6.6 0.38 2.26e-10 Gut microbiome composition (summer); CESC cis rs9682041 0.660 rs13089074 chr3:170113481 G/A cg11886554 chr3:170076028 SKIL 0.7 6.46 0.37 4.94e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs12477438 0.798 rs6732579 chr2:99560239 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.06 -0.53 2.22e-20 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23892547 chr17:29886066 MIR193A 0.54 6.35 0.36 9.13e-10 Gut microbiome composition (summer); CESC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg09177884 chr7:1199841 ZFAND2A -0.49 -6.15 -0.35 2.77e-9 Longevity;Endometriosis; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg18544450 chr19:14264896 LPHN1 0.43 6.36 0.36 9.05e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8180040 0.577 rs12493425 chr3:47176946 T/G cg27129171 chr3:47204927 SETD2 0.66 9.89 0.52 7.98e-20 Colorectal cancer; CESC cis rs5769765 0.908 rs9616213 chr22:50317851 T/G cg02269571 chr22:50332266 NA -0.57 -6.6 -0.38 2.28e-10 Schizophrenia; CESC cis rs6087990 1.000 rs2424901 chr20:31344512 A/G cg13636640 chr20:31349939 DNMT3B 0.91 16.04 0.7 6.22e-41 Ulcerative colitis; CESC cis rs2952156 0.920 rs2517954 chr17:37843550 T/C cg00129232 chr17:37814104 STARD3 -0.73 -9.72 -0.51 2.62e-19 Asthma; CESC cis rs412000 0.553 rs2680702 chr17:56431549 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.43 5.21 0.3 3.75e-7 Primary tooth development (time to first tooth eruption); CESC cis rs4268898 0.795 rs12470303 chr2:24619883 C/T cg06627628 chr2:24431161 ITSN2 -0.48 -5.73 -0.33 2.7e-8 Asthma; CESC cis rs6088590 0.561 rs6087600 chr20:33157217 T/C cg08999081 chr20:33150536 PIGU 0.7 12.65 0.61 5.4e-29 Coronary artery disease; CESC cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg23711669 chr6:146136114 FBXO30 1.01 15.7 0.69 1.05e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.45 -5.96 -0.34 8.06e-9 Bipolar disorder; CESC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg22903657 chr4:1355424 KIAA1530 -0.38 -5.17 -0.3 4.72e-7 Obesity-related traits; CESC cis rs7208859 0.623 rs7214570 chr17:29147164 A/G cg13385521 chr17:29058706 SUZ12P 0.69 5.64 0.33 4.44e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs941873 0.868 rs2145998 chr10:81121696 T/A cg11057378 chr10:81107060 PPIF 0.33 5.42 0.32 1.37e-7 Height; CESC cis rs631288 0.793 rs1530337 chr1:146683319 C/A cg25205988 chr1:146714368 CHD1L 1.05 6.69 0.38 1.28e-10 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg13206674 chr6:150067644 NUP43 0.41 5.61 0.33 5.2100000000000003e-08 Lung cancer; CESC cis rs68170813 0.559 rs7804979 chr7:106999453 C/G cg02696742 chr7:106810147 HBP1 -0.53 -5.16 -0.3 4.9e-7 Coronary artery disease; CESC cis rs9300255 0.722 rs10846515 chr12:123801672 T/G cg00376283 chr12:123451042 ABCB9 0.59 6.86 0.39 4.85e-11 Neutrophil percentage of white cells; CESC cis rs2302729 0.545 rs10161181 chr12:2770730 A/C cg19945202 chr12:2788847 CACNA1C -0.47 -7.08 -0.4 1.29e-11 Sleep quality; CESC cis rs910316 0.737 rs175049 chr14:75481368 C/T cg16144293 chr14:75469539 EIF2B2 0.39 5.15 0.3 5.01e-7 Height; CESC cis rs4727027 0.865 rs12154368 chr7:148862041 C/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.92 -0.39 3.45e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7707921 0.522 rs10070637 chr5:81490608 A/G cg15871215 chr5:81402204 ATG10 0.47 6.8 0.39 6.74e-11 Breast cancer; CESC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs1023500 0.552 rs5758566 chr22:42454354 G/A cg04733989 chr22:42467013 NAGA 0.79 11.89 0.59 2.06e-26 Schizophrenia; CESC cis rs2404602 0.692 rs55864032 chr15:77122548 A/G cg22467129 chr15:76604101 ETFA -0.34 -5.12 -0.3 5.97e-7 Blood metabolite levels; CESC cis rs12681288 0.823 rs4735974 chr8:1000218 T/G cg15309053 chr8:964076 NA 0.32 5.46 0.32 1.11e-7 Schizophrenia; CESC cis rs7605827 0.930 rs10200346 chr2:15635728 A/C cg19274914 chr2:15703543 NA 0.36 6.32 0.36 1.09e-9 Educational attainment (years of education); CESC trans rs7726839 0.561 rs11955068 chr5:582324 C/T cg25482853 chr8:67687455 SGK3 0.88 9.24 0.49 8.24e-18 Obesity-related traits; CESC cis rs9937943 0.615 rs35495670 chr16:74610422 T/C cg01733217 chr16:74700730 RFWD3 0.58 5.05 0.3 8.06e-7 Neutrophil percentage of white cells; CESC cis rs6963495 0.745 rs68153235 chr7:105184832 A/C cg13798780 chr7:105162888 PUS7 0.63 7.31 0.41 3.16e-12 Bipolar disorder (body mass index interaction); CESC cis rs290268 0.874 rs290995 chr9:93559477 C/A cg02608019 chr9:93564028 SYK 0.67 10.21 0.53 7.53e-21 Platelet count; CESC cis rs3812762 0.833 rs10500705 chr11:8805261 A/G cg03980550 chr11:8754370 ST5 -0.38 -5.3 -0.31 2.47e-7 Hypospadias; CESC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26723570 chr6:170102133 WDR27;C6orf120 -0.49 -6.4 -0.37 6.86e-10 Ulcerative colitis; CESC cis rs60843830 0.964 rs17713879 chr2:254215 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.42 0.54 1.61e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1878931 0.501 rs28735976 chr16:3418419 G/A cg05754148 chr16:3507555 NAT15 -0.39 -5.19 -0.3 4.24e-7 Body mass index (adult); CESC cis rs1559088 1.000 rs28840147 chr19:33561976 A/G cg27124370 chr19:33622961 WDR88 0.44 5.46 0.32 1.1e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs8067545 0.611 rs2526466 chr17:20165251 C/T cg13482628 chr17:19912719 NA -0.4 -5.19 -0.3 4.14e-7 Schizophrenia; CESC cis rs4835473 0.932 rs11100806 chr4:144682159 C/G cg25736465 chr4:144833511 NA 0.34 5.29 0.31 2.59e-7 Immature fraction of reticulocytes; CESC cis rs7639513 0.767 rs6784168 chr3:12702847 T/G cg23032965 chr3:12705835 RAF1 0.76 10.67 0.55 2.34e-22 Itch intensity from mosquito bite; CESC cis rs9399135 0.967 rs1854865 chr6:135360300 C/G cg24558204 chr6:135376177 HBS1L 0.49 6.84 0.39 5.41e-11 Red blood cell count; CESC cis rs9549367 0.577 rs776904 chr13:113810542 C/T cg18105134 chr13:113819100 PROZ -0.75 -8.35 -0.46 3.92e-15 Platelet distribution width; CESC cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg10523679 chr1:76189770 ACADM 0.72 8.4 0.46 2.82e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg27170947 chr2:26402098 FAM59B 0.85 10.0 0.52 3.45e-20 Gut microbiome composition (summer); CESC trans rs9975691 1 rs9975691 chr21:14928355 G/T cg11289296 chr17:74383131 SPHK1 -0.46 -6.07 -0.35 4.36e-9 Neurofibrillary tangles; CESC cis rs1691799 0.899 rs1168328 chr12:66729250 T/C cg16791601 chr12:66731901 HELB -0.78 -14.06 -0.65 6.2e-34 White blood cell count (basophil); CESC cis rs4523957 0.651 rs9894613 chr17:2071058 C/T cg16513277 chr17:2031491 SMG6 -0.72 -10.21 -0.53 7.63e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs4332037 0.539 rs55773130 chr7:2070554 T/C cg11693508 chr17:37793320 STARD3 0.66 6.66 0.38 1.57e-10 Bipolar disorder; CESC cis rs13242816 1.000 rs35515812 chr7:116156032 C/G cg04696780 chr7:116139425 CAV2 -0.61 -5.55 -0.32 7.01e-8 P wave duration; CESC cis rs113835537 0.529 rs3179961 chr11:66244454 A/G cg24851651 chr11:66362959 CCS 0.47 5.76 0.33 2.31e-8 Airway imaging phenotypes; CESC cis rs17253792 0.822 rs10483646 chr14:56103872 A/C cg24579896 chr14:56047964 C14orf33;KTN1 0.86 5.36 0.31 1.78e-7 Putamen volume; CESC trans rs10776614 0.799 rs7074631 chr10:49767369 G/A cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs2415984 0.600 rs72672853 chr14:46932920 T/G cg14871534 chr14:47121158 RPL10L -0.34 -5.12 -0.3 5.96e-7 Number of children ever born; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21205276 chr9:95056231 IARS;SNORA84 -0.44 -6.01 -0.35 6.2e-9 Gut microbiota (bacterial taxa); CESC cis rs7851660 0.967 rs4743134 chr9:100598568 C/A cg13688889 chr9:100608707 NA -0.68 -10.61 -0.55 3.8e-22 Strep throat; CESC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg00166722 chr3:10149974 C3orf24 0.48 5.95 0.34 8.64e-9 Alzheimer's disease; CESC cis rs9837602 1.000 rs923471 chr3:99757853 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.52 6.98 0.39 2.43e-11 Breast cancer; CESC cis rs2243480 1.000 rs67728539 chr7:65378124 G/A cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs9287719 0.967 rs3815521 chr2:10743654 G/C cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6912958 0.712 rs6930600 chr6:88349787 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.72 -0.38 1.09e-10 Monocyte percentage of white cells; CESC cis rs11122272 0.735 rs2486727 chr1:231539245 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -6.93 -0.39 3.24e-11 Hemoglobin concentration; CESC cis rs11577318 1.000 rs11577318 chr1:26601570 A/G cg19743891 chr1:26644573 UBXN11;CD52 0.36 5.08 0.3 7.25e-7 Granulocyte percentage of myeloid white cells; CESC cis rs1372520 0.684 rs3113355 chr4:90745345 A/T cg15133208 chr4:90757351 SNCA -0.4 -5.4 -0.31 1.48e-7 Neuroticism; CESC cis rs524281 0.814 rs10896098 chr11:65968416 G/A cg14036092 chr11:66035641 RAB1B -0.59 -6.08 -0.35 4.11e-9 Electroencephalogram traits; CESC cis rs9768139 0.935 rs6953748 chr7:158121184 G/A cg25566285 chr7:158114605 PTPRN2 -0.52 -8.89 -0.48 9.74e-17 Calcium levels; CESC cis rs11792861 0.591 rs7044275 chr9:111717138 T/C cg05043794 chr9:111880884 C9orf5 -0.32 -5.77 -0.33 2.18e-8 Menarche (age at onset); CESC cis rs1348850 0.574 rs11691740 chr2:178445161 A/G cg23306229 chr2:178417860 TTC30B -0.58 -5.83 -0.34 1.58e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.84 -12.08 -0.6 4.61e-27 Alzheimer's disease; CESC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg08704250 chr15:31115839 NA 0.63 8.61 0.47 6.65e-16 Huntington's disease progression; CESC cis rs9303401 0.614 rs28687626 chr17:57191904 G/A cg25039879 chr17:56429692 SUPT4H1 0.53 5.09 0.3 6.92e-7 Cognitive test performance; CESC cis rs644799 0.672 rs61902245 chr11:95517737 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.75 11.23 0.57 3.33e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs933688 0.938 rs10942634 chr5:90658392 A/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.08 14.28 0.66 1.07e-34 Smoking behavior; CESC trans rs324780 0.544 rs11115900 chr12:83923359 A/G cg22140261 chr22:42466895 NAGA -0.48 -6.07 -0.35 4.49e-9 Vertical cup-disc ratio; CESC cis rs9914544 0.966 rs1737943 chr17:18841590 A/G cg26378065 chr17:18585709 ZNF286B -0.42 -5.19 -0.3 4.23e-7 Educational attainment (years of education); CESC cis rs3806843 1.000 rs9686540 chr5:140174622 G/A cg26395211 chr5:140044315 WDR55 -0.41 -5.26 -0.31 2.97e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1153858 0.943 rs12439575 chr15:45684816 T/G cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs9303401 0.625 rs10515159 chr17:56802693 G/C cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.25 -0.31 3.11e-7 Lung cancer; CESC cis rs2070488 0.775 rs11926767 chr3:38527913 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.78 -11.99 -0.59 9.13e-27 Electrocardiographic conduction measures; CESC cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -6.74 -0.38 9.62e-11 Personality dimensions; CESC cis rs9329289 0.510 rs35854428 chr10:2554280 T/C cg15501526 chr10:2543763 NA 0.47 7.52 0.42 8.48e-13 Age-related hearing impairment; CESC cis rs1371867 0.846 rs1660349 chr8:101319326 G/A cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.1e-11 Atrioventricular conduction; CESC cis rs2742417 1.000 rs2742431 chr3:45737121 C/G cg10512202 chr3:45649293 LIMD1 -0.36 -5.32 -0.31 2.18e-7 Response to anti-depressant treatment in major depressive disorder; CESC cis rs992157 0.710 rs13026485 chr2:219057984 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.66 -8.82 -0.48 1.6e-16 Colorectal cancer; CESC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg22920501 chr2:26401640 FAM59B -0.67 -8.09 -0.45 2.16e-14 Gut microbiome composition (summer); CESC cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg10556349 chr10:835070 NA 0.54 5.81 0.34 1.83e-8 Eosinophil percentage of granulocytes; CESC cis rs34779708 0.931 rs4934535 chr10:35432721 G/T cg03585969 chr10:35415529 CREM 0.75 9.84 0.52 1.09e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs9303401 0.527 rs12946522 chr17:56768103 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.96 11.48 0.58 4.87e-25 Cognitive test performance; CESC cis rs35955747 0.902 rs4820961 chr22:31679449 C/T cg25791279 chr22:32026902 PISD -0.45 -5.5 -0.32 8.92e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs7809950 0.953 rs2253271 chr7:107201252 G/C cg23024343 chr7:107201750 COG5 -0.42 -5.89 -0.34 1.14e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09429345 chr3:138327826 FAIM 0.64 7.48 0.42 1.1e-12 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg04450456 chr4:17643702 FAM184B 0.37 5.25 0.31 3.17e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs508618 0.666 rs480902 chr1:231531627 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.42 5.42 0.32 1.33e-7 Red blood cell count; CESC cis rs2011503 1.000 rs2965178 chr19:19482911 T/G cg11584989 chr19:19387371 SF4 -0.62 -7.53 -0.42 7.83e-13 Bipolar disorder; CESC cis rs7824557 0.628 rs11782706 chr8:11186215 A/C cg21775007 chr8:11205619 TDH 0.55 8.57 0.47 8.45e-16 Retinal vascular caliber; CESC cis rs2979489 0.945 rs11993146 chr8:30319537 G/A cg26383811 chr8:30366931 RBPMS -0.81 -10.02 -0.52 2.96e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg11812906 chr14:75593930 NEK9 -0.87 -14.35 -0.66 5.82e-35 Height; CESC cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.63 9.78 0.51 1.79e-19 Personality dimensions; CESC cis rs12477438 0.798 rs6712338 chr2:99585457 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs1355223 0.583 rs2915238 chr11:34884405 C/A cg11058730 chr11:34937778 PDHX;APIP 0.86 13.16 0.63 9.16e-31 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs61841072 0.961 rs6672908 chr1:243126730 G/A cg02356786 chr1:243265016 LOC731275 0.4 5.03 0.3 9.1e-7 Schizophrenia; CESC cis rs30380 0.632 rs26500 chr5:96133712 A/C cg16492584 chr5:96139282 ERAP1 -0.49 -6.84 -0.39 5.49e-11 Cerebrospinal fluid biomarker levels; CESC trans rs2018683 0.707 rs4722878 chr7:28973031 C/T cg19402173 chr7:128379420 CALU -0.51 -6.73 -0.38 1.06e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs9527 0.615 rs10883811 chr10:104727279 A/G cg04362960 chr10:104952993 NT5C2 0.42 5.28 0.31 2.7e-7 Arsenic metabolism; CESC cis rs2361718 0.564 rs2304844 chr17:78084507 G/C cg20811857 chr17:78079795 GAA -0.43 -6.26 -0.36 1.58e-9 Yeast infection; CESC cis rs7017914 1.000 rs13252719 chr8:71734569 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.43 -5.57 -0.32 6.34e-8 Bone mineral density; CESC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg23048001 chr7:2026167 MAD1L1 0.46 6.09 0.35 3.91e-9 Bipolar disorder and schizophrenia; CESC cis rs2710642 0.611 rs6749020 chr2:62861957 G/A cg17519650 chr2:63277830 OTX1 0.47 5.54 0.32 7.36e-8 LDL cholesterol levels;LDL cholesterol; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg19936885 chr3:9404556 THUMPD3 0.48 6.49 0.37 4.23e-10 Positive affect; CESC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.97 0.59 1.1e-26 Alzheimer's disease; CESC cis rs72627123 0.867 rs75773875 chr14:74498053 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.79 5.85 0.34 1.48e-8 Morning vs. evening chronotype; CESC cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg22875332 chr1:76189707 ACADM 0.63 6.26 0.36 1.52e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg12524338 chr4:183729343 NA 0.52 5.12 0.3 5.98e-7 Pediatric autoimmune diseases; CESC cis rs2040771 0.804 rs1340958 chr22:19253332 A/G cg02655711 chr22:19163373 SLC25A1 -0.41 -6.0 -0.35 6.47e-9 Metabolite levels (small molecules and protein measures); CESC cis rs6460942 0.597 rs13245635 chr7:12526454 T/A cg20607287 chr7:12443886 VWDE -0.71 -7.67 -0.43 3.19e-13 Coronary artery disease; CESC cis rs939658 0.626 rs11636901 chr15:79446292 T/C cg17916960 chr15:79447300 NA -0.31 -5.06 -0.3 7.79e-7 Refractive error; CESC cis rs6088590 0.561 rs6088527 chr20:33155841 C/T cg08999081 chr20:33150536 PIGU 0.69 12.25 0.6 1.2100000000000001e-27 Coronary artery disease; CESC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg11764359 chr7:65958608 NA -0.91 -14.51 -0.67 1.64e-35 Aortic root size; CESC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg05368731 chr17:41323189 NBR1 0.78 10.79 0.55 9.37e-23 Menopause (age at onset); CESC cis rs763121 0.853 rs6001185 chr22:39052155 G/A cg14440974 chr22:39074834 NA -0.4 -5.49 -0.32 9.53e-8 Menopause (age at onset); CESC cis rs9929218 1.000 rs28660361 chr16:68800838 T/C cg02972257 chr16:68554789 NA 0.43 5.22 0.31 3.65e-7 Colorectal cancer; CESC cis rs3617 0.539 rs12629687 chr3:52950659 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.32 -5.4 -0.31 1.5e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs4805272 0.512 rs7260055 chr19:29341599 G/A cg12756686 chr19:29218302 NA 0.43 5.86 0.34 1.37e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs8072100 0.666 rs6503804 chr17:45772447 G/A cg08085267 chr17:45401833 C17orf57 -0.43 -5.43 -0.32 1.27e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg15445000 chr17:37608096 MED1 0.4 6.38 0.36 7.97e-10 Glomerular filtration rate (creatinine); CESC cis rs1062177 1.000 rs2016409 chr5:151126324 G/T cg00977110 chr5:151150581 G3BP1 -0.68 -6.89 -0.39 4.15e-11 Preschool internalizing problems; CESC cis rs2742234 0.590 rs741968 chr10:43611708 A/G cg15436174 chr10:43711423 RASGEF1A -0.45 -5.35 -0.31 1.94e-7 Hirschsprung disease; CESC cis rs2425143 0.841 rs4911519 chr20:34362326 A/T cg23207816 chr20:34252616 CPNE1;RBM12 -0.72 -6.67 -0.38 1.52e-10 Blood protein levels; CESC cis rs2228479 0.850 rs12597299 chr16:89822364 C/A cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg10792982 chr14:105748885 BRF1 0.42 5.38 0.31 1.63e-7 Mean platelet volume;Platelet distribution width; CESC cis rs6580649 1.000 rs9805048 chr12:48403692 C/T cg05342945 chr12:48394962 COL2A1 -0.54 -6.75 -0.38 9.25e-11 Lung cancer; CESC cis rs4891159 0.790 rs59762437 chr18:74153146 G/A cg24786174 chr18:74118243 ZNF516 -0.74 -10.88 -0.56 5.03e-23 Longevity; CESC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg11663144 chr21:46675770 NA -0.62 -9.83 -0.52 1.19e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7246760 0.867 rs35416342 chr19:9779058 A/G cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs7116495 0.609 rs2845860 chr11:71716661 C/T cg07596299 chr11:71824057 C11orf51 -0.85 -5.7 -0.33 3.12e-8 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18961773 chr17:74222942 RNF157 -0.53 -6.72 -0.38 1.11e-10 Gut microbiome composition (summer); CESC cis rs73206853 0.764 rs56123836 chr12:110999032 G/A cg12870014 chr12:110450643 ANKRD13A 0.65 5.65 0.33 4.09e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs4824093 0.610 rs2208023 chr22:50249983 A/G cg09872104 chr7:134855509 C7orf49 -0.94 -6.62 -0.38 1.99e-10 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6933660 0.646 rs6915598 chr6:151778664 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.53 5.39 0.31 1.59e-7 Menarche (age at onset); CESC cis rs2228479 0.850 rs17227064 chr16:89816314 A/G cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs1006703 0.544 rs34713010 chr17:3834718 A/G cg06463185 chr17:3833770 ATP2A3 -0.56 -6.01 -0.35 6.17e-9 Glucose homeostasis traits; CESC cis rs9443189 0.570 rs775075 chr6:76380035 A/C cg01950844 chr6:76311363 SENP6 -0.87 -9.27 -0.49 6.59e-18 Prostate cancer; CESC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg05332525 chr7:65337924 VKORC1L1 0.5 6.18 0.36 2.35e-9 Aortic root size; CESC cis rs7726839 0.561 rs4957049 chr5:579080 C/A cg16447950 chr5:562315 NA -0.58 -6.74 -0.38 9.99e-11 Obesity-related traits; CESC cis rs1915146 0.546 rs9422857 chr10:126861278 C/G cg23000734 chr10:126850823 CTBP2 0.54 8.01 0.44 3.69e-14 Menarche (age at onset); CESC trans rs9929218 1.000 rs12446575 chr16:68791644 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.71 -8.97 -0.48 5.37e-17 Colorectal cancer; CESC cis rs9309473 0.898 rs6546861 chr2:73849861 C/T cg20560298 chr2:73613845 ALMS1 -0.45 -5.89 -0.34 1.17e-8 Metabolite levels; CESC cis rs6088590 0.648 rs6059991 chr20:33280836 C/T cg06115741 chr20:33292138 TP53INP2 0.55 6.7 0.38 1.24e-10 Coronary artery disease; CESC cis rs920590 0.642 rs6993525 chr8:19671104 A/G cg03894339 chr8:19674705 INTS10 -0.6 -7.01 -0.4 1.95e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs17401966 0.931 rs17034821 chr1:10414645 A/G cg15208524 chr1:10270712 KIF1B 0.41 5.18 0.3 4.35e-7 Hepatocellular carcinoma; CESC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg12463550 chr7:65579703 CRCP 0.58 7.41 0.41 1.67e-12 Aortic root size; CESC cis rs1461503 0.966 rs10892939 chr11:122841959 T/C cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs9309711 0.922 rs13431788 chr2:3482912 G/A cg10845886 chr2:3471009 TTC15 -0.87 -12.13 -0.6 3.07e-27 Neurofibrillary tangles; CESC cis rs614226 1.000 rs541126 chr12:120972396 C/T cg01236616 chr12:121019343 POP5 -1.53 -18.68 -0.75 2.86e-50 Type 1 diabetes nephropathy; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg09431544 chr19:14629187 DNAJB1 0.48 6.27 0.36 1.43e-9 Breast cancer;Type 2 diabetes; CESC cis rs2576037 0.796 rs2576038 chr18:44582200 C/G cg19077165 chr18:44547161 KATNAL2 0.51 7.15 0.4 8.58e-12 Personality dimensions; CESC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs6502050 0.835 rs7221544 chr17:80087337 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.13 0.3 5.68e-7 Life satisfaction; CESC cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.74 0.51 2.39e-19 Age-related macular degeneration (geographic atrophy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26859586 chr10:104953231 NT5C2 0.63 7.42 0.41 1.58e-12 Gut microbiome composition (summer); CESC cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg15541040 chr2:3486749 NA 0.44 5.48 0.32 9.91e-8 Neurofibrillary tangles; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15884411 chr2:96932403 CIAO1;TMEM127 0.5 6.25 0.36 1.6e-9 Gut microbiota (bacterial taxa); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02355411 chr19:49700427 TRPM4 -0.35 -6.1 -0.35 3.71e-9 Gambling; CESC cis rs2288912 0.838 rs7251503 chr19:45455715 C/G cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.51e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg15112475 chr7:1198522 ZFAND2A -0.46 -7.68 -0.43 3.13e-13 Longevity;Endometriosis; CESC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg03396347 chr1:1875803 NA -0.46 -7.13 -0.4 9.43e-12 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04522931 chr7:30324582 ZNRF2 -0.5 -7.01 -0.4 2e-11 Fibrinogen levels; CESC trans rs7819412 0.740 rs7844536 chr8:11034028 A/G cg06636001 chr8:8085503 FLJ10661 -0.65 -7.87 -0.44 9.32e-14 Triglycerides; CESC cis rs12190007 0.547 rs2981945 chr6:169819839 G/A cg15038512 chr6:170123185 PHF10 -0.51 -7.26 -0.41 4.43e-12 Obesity-related traits; CESC cis rs2295499 0.754 rs4690052 chr4:2736567 C/T cg27239842 chr4:2403781 ZFYVE28 -0.32 -5.15 -0.3 5.12e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07556730 chr11:679706 DEAF1 0.47 6.63 0.38 1.84e-10 Fibrinogen levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07805240 chr7:8008383 GLCCI1 -0.47 -6.26 -0.36 1.51e-9 Ulcerative colitis; CESC cis rs35079168 0.923 rs11103473 chr9:137287629 A/T cg13941235 chr9:137270186 RXRA 0.31 5.62 0.33 4.88e-8 Intelligence; CESC cis rs4148883 0.713 rs3828541 chr4:100042262 A/G cg13256891 chr4:100009986 ADH5 0.57 7.6 0.42 4.99e-13 Alcohol dependence; CESC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.07 -0.44 2.52e-14 Personality dimensions; CESC cis rs4474465 1.000 rs7943815 chr11:78173160 A/G cg27205649 chr11:78285834 NARS2 -0.41 -5.11 -0.3 6.27e-7 Alzheimer's disease (survival time); CESC cis rs9297145 0.761 rs62473015 chr7:98763301 G/A cg05967295 chr7:98741636 SMURF1 0.9 9.34 0.5 4.06e-18 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs7267979 0.844 rs4423675 chr20:25402778 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.78 -14.59 -0.67 8.55e-36 Liver enzyme levels (alkaline phosphatase); CESC trans rs7819412 0.715 rs35223712 chr8:11043926 C/T cg15556689 chr8:8085844 FLJ10661 -0.53 -6.47 -0.37 4.65e-10 Triglycerides; CESC cis rs60843830 1.000 rs10193373 chr2:281886 T/G cg00108164 chr2:264199 ACP1;SH3YL1 0.78 9.95 0.52 4.96e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs8050907 0.744 rs8063956 chr16:4531761 T/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.89 6.22 0.36 1.94e-9 Obesity-related traits; CESC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs116095464 0.558 rs10043002 chr5:226753 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.66 -0.47 4.79e-16 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12095720 chr17:72978304 NA 0.55 6.34 0.36 9.63e-10 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg24060327 chr5:131705240 SLC22A5 0.8 11.21 0.57 3.88e-24 Blood metabolite levels; CESC cis rs1707322 1.000 rs11211235 chr1:46440375 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2249625 0.545 rs10498880 chr6:72882183 G/T cg18830697 chr6:72922368 RIMS1 0.42 5.94 0.34 8.7e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs6594499 0.903 rs1438672 chr5:110467753 G/A cg04022379 chr5:110408740 TSLP 0.34 5.99 0.35 6.74e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs2228479 0.850 rs74251568 chr16:89903416 A/C cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg04944784 chr2:26401820 FAM59B 0.74 8.77 0.47 2.15e-16 Gut microbiome composition (summer); CESC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg20291162 chr17:40259547 DHX58 0.44 5.96 0.34 7.93e-9 Fibrinogen levels; CESC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.67 9.42 0.5 2.33e-18 Menarche (age at onset); CESC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg00684032 chr4:1343700 KIAA1530 0.39 5.46 0.32 1.11e-7 Obesity-related traits; CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg18538332 chr22:24372958 LOC391322 -0.77 -11.28 -0.57 2.4e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9660992 0.573 rs12140422 chr1:205187981 G/A cg00857998 chr1:205179979 DSTYK 0.54 6.73 0.38 1.06e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.1 0.4 1.14e-11 Tonsillectomy; CESC cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg18180107 chr4:99064573 C4orf37 0.41 5.34 0.31 1.98e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20703320 chr12:111021296 PPTC7 -0.5 -6.33 -0.36 1.01e-9 Asthma; CESC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg21770322 chr7:97807741 LMTK2 0.55 8.07 0.44 2.41e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg03467027 chr4:99064603 C4orf37 0.42 5.17 0.3 4.56e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.533 rs34668726 chr2:23895901 C/G cg08917208 chr2:24149416 ATAD2B 1.01 9.71 0.51 2.84e-19 Lymphocyte counts; CESC cis rs6835098 0.961 rs11737748 chr4:174130503 T/C cg08422745 chr4:174089978 GALNT7 0.73 9.26 0.49 7.24e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs258892 0.895 rs13181060 chr5:72071769 T/C cg21869765 chr5:72125136 TNPO1 -0.37 -5.05 -0.3 8.41e-7 Small cell lung carcinoma; CESC trans rs997295 0.529 rs12592315 chr15:68040266 A/G cg12489069 chr17:26898961 PIGS 0.47 6.06 0.35 4.63e-9 Motion sickness; CESC cis rs79349575 0.811 rs80032154 chr17:47014992 C/A cg16584676 chr17:46985605 UBE2Z 0.49 5.87 0.34 1.31e-8 Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09430954 chr19:46236890 NA 0.48 6.63 0.38 1.91e-10 Fibrinogen levels; CESC cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg12193833 chr17:30244370 NA -0.72 -6.32 -0.36 1.07e-9 Hip circumference adjusted for BMI; CESC cis rs11098499 0.954 rs12505469 chr4:120249585 C/T cg09307838 chr4:120376055 NA 0.91 12.63 0.61 6.24e-29 Corneal astigmatism; CESC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg11301795 chr4:187892539 NA -0.75 -11.49 -0.58 4.49e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs35685312 chr4:98858521 G/A cg17366294 chr4:99064904 C4orf37 0.55 7.72 0.43 2.38e-13 Colonoscopy-negative controls vs population controls; CESC cis rs11078597 0.731 rs2287322 chr17:1641035 A/G cg18436246 chr17:1640651 WDR81 0.63 7.64 0.42 4.07e-13 Serum albumin level; CESC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg18016565 chr1:150552671 MCL1 0.33 5.16 0.3 4.96e-7 Tonsillectomy; CESC cis rs7542091 0.579 rs34638782 chr1:210032055 C/G cg05527609 chr1:210001259 C1orf107 -0.45 -5.72 -0.33 2.91e-8 Monobrow; CESC cis rs7116495 0.867 rs4378421 chr11:71761996 T/C cg07596299 chr11:71824057 C11orf51 -1.01 -6.0 -0.35 6.58e-9 Severe influenza A (H1N1) infection; CESC cis rs7666738 0.830 rs11725652 chr4:98878362 G/A cg05340658 chr4:99064831 C4orf37 0.75 11.15 0.56 6.44e-24 Colonoscopy-negative controls vs population controls; CESC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.44 -5.2 -0.3 4e-7 Breast cancer; CESC cis rs7799006 0.755 rs12534131 chr7:2294123 C/T cg12745145 chr7:2261452 MAD1L1 -0.32 -5.09 -0.3 6.8e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4835473 0.801 rs76574827 chr4:144658456 G/A cg25736465 chr4:144833511 NA -0.33 -5.25 -0.31 3.1e-7 Immature fraction of reticulocytes; CESC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg22800045 chr5:56110881 MAP3K1 -0.6 -7.71 -0.43 2.55e-13 Initial pursuit acceleration; CESC cis rs7845219 0.539 rs13271644 chr8:95853948 A/G cg23172400 chr8:95962367 TP53INP1 -0.31 -5.71 -0.33 3.07e-8 Type 2 diabetes; CESC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg03452623 chr4:187889614 NA 0.84 14.53 0.67 1.35e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs11997175 0.766 rs4442096 chr8:33691039 T/C ch.8.33884649F chr8:33765107 NA 0.44 5.56 0.32 6.56e-8 Body mass index; CESC cis rs4835473 0.864 rs1597446 chr4:144629491 A/G cg25736465 chr4:144833511 NA 0.4 6.17 0.35 2.59e-9 Immature fraction of reticulocytes; CESC cis rs8038465 0.592 rs1542580 chr15:73935834 C/G cg15420318 chr15:73925796 NPTN 0.51 7.15 0.4 8.69e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg07505334 chr10:13629015 PRPF18 -0.47 -6.42 -0.37 6.26e-10 Thyroid stimulating hormone; CESC cis rs854765 0.929 rs2955360 chr17:17974887 G/A cg16928487 chr17:17741425 SREBF1 0.53 8.99 0.48 4.88e-17 Total body bone mineral density; CESC cis rs7582720 0.778 rs6719001 chr2:203777903 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs12618769 0.652 rs72823801 chr2:99235055 A/G cg10123293 chr2:99228465 UNC50 0.41 5.4 0.31 1.51e-7 Bipolar disorder; CESC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg18876405 chr7:65276391 NA -0.52 -7.16 -0.4 7.95e-12 Aortic root size; CESC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg08704250 chr15:31115839 NA 0.62 8.01 0.44 3.54e-14 Huntington's disease progression; CESC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg15445000 chr17:37608096 MED1 -0.42 -6.97 -0.39 2.51e-11 Glomerular filtration rate (creatinine); CESC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 8.82 0.48 1.51e-16 Platelet count; CESC cis rs4237845 0.537 rs11172369 chr12:58280592 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.52 5.75 0.33 2.5e-8 Intelligence (multi-trait analysis); CESC cis rs9388451 0.903 rs9388446 chr6:126064920 T/A cg10911889 chr6:126070802 HEY2 0.39 5.47 0.32 1.05e-7 Brugada syndrome; CESC cis rs72627123 0.867 rs74492048 chr14:74439895 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.76 5.04 0.3 8.57e-7 Morning vs. evening chronotype; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02803047 chr19:50643420 SNAR-B1;SNAR-B2 -0.36 -6.33 -0.36 1.04e-9 Gut microbiota (bacterial taxa); CESC cis rs10782582 0.545 rs12138018 chr1:76186794 T/C cg10523679 chr1:76189770 ACADM -0.44 -5.16 -0.3 4.95e-7 Daytime sleep phenotypes; CESC cis rs7814319 0.674 rs2292835 chr8:97243720 G/A cg20787634 chr8:97240163 UQCRB -0.55 -6.47 -0.37 4.6e-10 Lung function (FVC); CESC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg04025307 chr7:1156635 C7orf50 0.45 5.3 0.31 2.41e-7 Bronchopulmonary dysplasia; CESC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg24250549 chr1:154909240 PMVK 0.71 10.45 0.54 1.29e-21 Prostate cancer; CESC cis rs4604732 0.631 rs75600450 chr1:247625492 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.1 0.4 1.11e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11645898 0.687 rs72787058 chr16:72105084 C/T cg14768367 chr16:72042858 DHODH -0.6 -5.13 -0.3 5.47e-7 Blood protein levels; CESC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg00612595 chr21:47717864 NA 0.42 5.69 0.33 3.43e-8 Testicular germ cell tumor; CESC cis rs6032067 0.929 rs6017510 chr20:43831785 A/G cg10761708 chr20:43804764 PI3 0.52 6.32 0.36 1.07e-9 Blood protein levels; CESC cis rs9611565 0.592 rs80477 chr22:42001183 C/T cg06634786 chr22:41940651 POLR3H 0.55 5.96 0.34 8e-9 Vitiligo; CESC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg20999797 chr1:1681921 NA 0.28 5.35 0.31 1.9e-7 Body mass index; CESC cis rs9549260 0.755 rs3900833 chr13:41188292 A/G cg21288729 chr13:41239152 FOXO1 0.61 7.66 0.43 3.49e-13 Red blood cell count; CESC cis rs12220238 1.000 rs10824084 chr10:75911415 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.66 6.68 0.38 1.42e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs72901758 0.696 rs72909029 chr17:76249451 A/G cg26068271 chr17:76253126 NA 0.43 6.16 0.35 2.71e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs78456975 0.657 rs116217838 chr2:1569173 T/C cg12573674 chr2:1569213 NA -0.47 -5.37 -0.31 1.68e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7267979 0.932 rs446649 chr20:25467359 A/G cg08601574 chr20:25228251 PYGB 0.37 5.62 0.33 4.9e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg12419862 chr22:24373484 LOC391322 -0.74 -10.49 -0.54 9.52e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7116495 0.609 rs4387373 chr11:71774908 A/G cg07596299 chr11:71824057 C11orf51 -0.93 -5.87 -0.34 1.32e-8 Severe influenza A (H1N1) infection; CESC cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.76 9.53 0.51 1.09e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs3733585 0.624 rs76574510 chr4:9953252 T/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.84 9.0 0.48 4.4e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3806933 0.522 rs13186912 chr5:110456704 A/T cg04022379 chr5:110408740 TSLP -0.43 -7.22 -0.41 5.48e-12 Eosinophilic esophagitis; CESC cis rs9300255 0.722 rs28592876 chr12:123866429 G/A cg00376283 chr12:123451042 ABCB9 -0.59 -6.67 -0.38 1.46e-10 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04262179 chr1:178482030 C1orf49 -0.62 -6.82 -0.39 6.03e-11 Gut microbiome composition (summer); CESC cis rs2637266 0.626 rs2583067 chr10:78555804 A/G cg18941641 chr10:78392320 NA 0.41 7.79 0.43 1.51e-13 Pulmonary function; CESC cis rs1707322 0.691 rs61784803 chr1:46179271 C/A cg06784218 chr1:46089804 CCDC17 -0.43 -7.58 -0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11717552 chr14:23311678 MMP14 0.48 6.85 0.39 5.14e-11 Fibrinogen levels; CESC cis rs9916302 0.904 rs35285898 chr17:37555872 A/C cg15445000 chr17:37608096 MED1 -0.41 -6.74 -0.38 9.67e-11 Glomerular filtration rate (creatinine); CESC cis rs7772486 0.743 rs9376955 chr6:145949404 T/A cg05347473 chr6:146136440 FBXO30 0.49 6.51 0.37 3.71e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs72945132 0.882 rs3900797 chr11:70186614 C/T cg00319359 chr11:70116639 PPFIA1 0.71 6.83 0.39 5.73e-11 Coronary artery disease; CESC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg18099408 chr3:52552593 STAB1 -0.34 -5.61 -0.33 5.02e-8 Bipolar disorder; CESC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg24531977 chr5:56204891 C5orf35 -0.49 -6.0 -0.35 6.46e-9 Coronary artery disease; CESC cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg06212747 chr3:49208901 KLHDC8B 0.65 8.81 0.48 1.68e-16 Parkinson's disease; CESC cis rs965469 0.843 rs6037597 chr20:3408374 A/G cg25506879 chr20:3388711 C20orf194 -0.47 -5.12 -0.3 5.96e-7 IFN-related cytopenia; CESC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg06873352 chr17:61820015 STRADA 0.73 13.07 0.63 1.78e-30 Prudent dietary pattern; CESC cis rs7809950 0.784 rs7803102 chr7:107248929 T/G cg23024343 chr7:107201750 COG5 0.43 6.06 0.35 4.74e-9 Coronary artery disease; CESC cis rs400736 0.562 rs10864331 chr1:8172178 A/G cg25007680 chr1:8021821 PARK7 -0.47 -6.06 -0.35 4.64e-9 Response to antidepressants and depression; CESC cis rs2777491 1.000 rs7177641 chr15:41743426 C/T cg02330683 chr15:41787940 ITPKA 0.49 7.24 0.41 5.01e-12 Ulcerative colitis; CESC cis rs7539409 0.651 rs10747407 chr1:84314754 G/A cg10977910 chr1:84465055 TTLL7 0.78 7.42 0.41 1.61e-12 Alzheimer's disease; CESC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg00149659 chr3:10157352 C3orf10 0.76 9.51 0.5 1.26e-18 Alzheimer's disease; CESC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg26441486 chr22:50317300 CRELD2 -0.37 -5.11 -0.3 6.26e-7 Schizophrenia; CESC cis rs7927592 0.913 rs7925275 chr11:68290433 T/C cg16797656 chr11:68205561 LRP5 0.37 5.04 0.3 8.47e-7 Total body bone mineral density; CESC cis rs6121246 0.609 rs6087783 chr20:30421224 T/G cg13852791 chr20:30311386 BCL2L1 0.84 10.86 0.55 5.92e-23 Mean corpuscular hemoglobin; CESC cis rs7131987 0.676 rs10843407 chr12:29550244 A/G cg09582351 chr12:29534625 ERGIC2 0.35 5.54 0.32 7.23e-8 QT interval; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19794706 chr14:75643232 TMED10 -0.42 -6.07 -0.35 4.4e-9 Fibrinogen levels; CESC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg10150615 chr22:24372951 LOC391322 -0.59 -7.99 -0.44 4.18e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7178572 0.633 rs7162637 chr15:77843365 A/G cg22256960 chr15:77711686 NA -0.53 -6.58 -0.37 2.47e-10 Type 2 diabetes; CESC cis rs4253772 0.591 rs6007748 chr22:46657798 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 7.98 0.44 4.41e-14 LDL cholesterol;Cholesterol, total; CESC cis rs6752107 1.000 rs2241878 chr2:234183718 T/C cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.38 5.68 0.33 3.53e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs9389248 0.690 rs728030 chr6:135246294 G/T cg22676075 chr6:135203613 NA -0.59 -8.35 -0.46 3.96e-15 High light scatter reticulocyte percentage of red cells; CESC cis rs9815354 0.855 rs73071261 chr3:42003369 C/A cg03022575 chr3:42003672 ULK4 0.66 5.77 0.33 2.17e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs7827545 1.000 rs6578234 chr8:135566363 A/G cg17885191 chr8:135476712 NA 0.47 6.22 0.36 1.94e-9 Hypertension (SNP x SNP interaction); CESC cis rs9487051 0.639 rs2884012 chr6:109598221 C/T cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC cis rs9308731 0.591 rs6542350 chr2:111944740 C/T cg04202892 chr2:111875749 ACOXL 0.41 5.81 0.34 1.8e-8 Chronic lymphocytic leukemia; CESC cis rs1008375 1.000 rs13119927 chr4:17691640 G/A cg02297831 chr4:17616191 MED28 -0.55 -6.48 -0.37 4.38e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11792861 0.962 rs72607162 chr9:111793719 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.46 5.76 0.33 2.35e-8 Menarche (age at onset); CESC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg22535103 chr8:58192502 C8orf71 -1.04 -13.3 -0.63 2.89e-31 Developmental language disorder (linguistic errors); CESC cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg10645314 chr2:3704589 ALLC -0.49 -5.54 -0.32 7.25e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs6060717 0.536 rs11696912 chr20:34497660 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.72 6.7 0.38 1.24e-10 Hip circumference adjusted for BMI; CESC cis rs314370 0.855 rs17883557 chr7:100494949 G/T cg10426581 chr7:100472382 SRRT 0.84 8.18 0.45 1.23e-14 Resting heart rate; CESC trans rs7819412 0.807 rs4840542 chr8:10944809 G/T cg06636001 chr8:8085503 FLJ10661 -0.51 -6.16 -0.35 2.76e-9 Triglycerides; CESC cis rs250677 0.687 rs250672 chr5:148446110 A/G cg18129178 chr5:148520854 ABLIM3 -0.51 -5.83 -0.34 1.58e-8 Breast cancer; CESC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg12463550 chr7:65579703 CRCP 0.56 7.24 0.41 4.94e-12 Aortic root size; CESC cis rs7216064 0.954 rs12602556 chr17:65826861 A/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.5 -0.46 1.42e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs78366141 0.536 rs76806573 chr4:89682729 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.78 5.23 0.31 3.48e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs546131 0.820 rs744841 chr11:34857667 G/A cg11058730 chr11:34937778 PDHX;APIP 0.46 5.9 0.34 1.13e-8 Lung disease severity in cystic fibrosis; CESC cis rs10911232 0.507 rs35782443 chr1:183051502 A/C ch.1.3577855R chr1:183094577 LAMC1 0.85 13.7 0.64 1.21e-32 Hypertriglyceridemia; CESC cis rs1348850 0.526 rs7607073 chr2:178375065 C/A cg23306229 chr2:178417860 TTC30B 0.78 6.92 0.39 3.32e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg15782153 chr7:917662 C7orf20 -0.49 -5.41 -0.32 1.4e-7 Cerebrospinal P-tau181p levels; CESC cis rs6121246 0.609 rs2376998 chr20:30340663 T/C cg13852791 chr20:30311386 BCL2L1 0.81 10.36 0.54 2.4e-21 Mean corpuscular hemoglobin; CESC cis rs6570726 1.000 rs436066 chr6:145847127 C/T cg23711669 chr6:146136114 FBXO30 0.77 11.53 0.58 3.48e-25 Lobe attachment (rater-scored or self-reported); CESC trans rs9951602 0.512 rs77157626 chr18:76644771 C/T cg02800362 chr5:177631904 HNRNPAB 0.62 8.1 0.45 1.96e-14 Obesity-related traits; CESC cis rs3858526 0.883 rs10769326 chr11:5934358 C/T cg05234568 chr11:5960015 NA -0.49 -5.77 -0.33 2.15e-8 DNA methylation (variation); CESC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg25072359 chr17:41440525 NA 0.48 6.54 0.37 3.13e-10 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21300719 chr1:201097122 NA 0.48 6.96 0.39 2.67e-11 Fibrinogen levels; CESC cis rs9300255 0.537 rs1618679 chr12:123650714 A/G cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.16e-16 Neutrophil percentage of white cells; CESC cis rs977987 0.806 rs11648176 chr16:75456423 C/G cg03315344 chr16:75512273 CHST6 0.41 5.89 0.34 1.16e-8 Dupuytren's disease; CESC cis rs4588572 0.643 rs10075726 chr5:77669053 T/A cg11547950 chr5:77652471 NA 0.44 5.59 0.32 5.56e-8 Triglycerides; CESC cis rs7208859 0.623 rs7220999 chr17:29149298 C/T cg13385521 chr17:29058706 SUZ12P 0.8 6.38 0.37 7.71e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg04553112 chr3:125709451 NA -0.54 -5.75 -0.33 2.4e-8 Blood pressure (smoking interaction); CESC cis rs1800795 0.901 rs2069833 chr7:22767664 C/T cg05265849 chr7:22767390 IL6 0.5 6.5 0.37 3.86e-10 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CESC cis rs9894429 1.000 rs7222241 chr17:79574714 C/G cg18240062 chr17:79603768 NPLOC4 0.71 9.98 0.52 3.97e-20 Eye color traits; CESC cis rs1801251 1.000 rs13035829 chr2:233604487 A/T cg25237894 chr2:233734115 C2orf82 0.44 7.55 0.42 7.05e-13 Coronary artery disease; CESC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg13206674 chr6:150067644 NUP43 0.46 6.67 0.38 1.5e-10 Lung cancer; CESC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg02269571 chr22:50332266 NA -0.56 -6.99 -0.39 2.26e-11 Schizophrenia; CESC cis rs1797885 1.000 rs709164 chr3:12514157 A/G cg26432171 chr3:12704882 RAF1 -0.5 -6.47 -0.37 4.75e-10 Immature fraction of reticulocytes; CESC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg18350739 chr11:68623251 NA -0.46 -7.02 -0.4 1.88e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg02038168 chr22:39784481 NA -0.62 -7.72 -0.43 2.38e-13 Intelligence (multi-trait analysis); CESC cis rs9640161 0.789 rs28439010 chr7:150046276 C/T cg27494647 chr7:150038898 RARRES2 0.41 5.08 0.3 7.15e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs9303401 0.659 rs56162835 chr17:56687315 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.13 0.63 1.12e-30 Cognitive test performance; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20560906 chr3:47459876 SCAP 0.53 7.07 0.4 1.39e-11 Fibrinogen levels; CESC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.47 0.42 1.18e-12 Electroencephalogram traits; CESC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg01416388 chr22:39784598 NA -0.59 -7.18 -0.4 6.84e-12 Intelligence (multi-trait analysis); CESC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg07343612 chr16:622815 PIGQ -0.54 -7.96 -0.44 5.21e-14 Height; CESC cis rs965469 1.000 rs6037567 chr20:3332160 C/A cg25506879 chr20:3388711 C20orf194 -0.54 -5.78 -0.33 2.14e-8 IFN-related cytopenia; CESC cis rs7149337 0.804 rs4131981 chr14:51667504 A/T cg23942311 chr14:51606299 NA -0.42 -7.04 -0.4 1.68e-11 Cancer; CESC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg07677032 chr17:61819896 STRADA 0.46 6.18 0.35 2.43e-9 Prudent dietary pattern; CESC cis rs11098499 0.913 rs11098496 chr4:120167466 C/G cg09307838 chr4:120376055 NA 0.86 11.46 0.58 5.96e-25 Corneal astigmatism; CESC cis rs7085104 0.632 rs6162 chr10:104596981 G/A cg15744005 chr10:104629667 AS3MT -0.33 -5.16 -0.3 4.91e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs4566357 0.595 rs10206912 chr2:227921095 A/T cg05526886 chr2:227700861 RHBDD1 -0.48 -6.5 -0.37 4.04e-10 Coronary artery disease; CESC cis rs936229 0.768 rs11072509 chr15:75114374 C/G cg14664628 chr15:75095509 CSK -1.0 -16.17 -0.7 2.21e-41 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC trans rs6499188 0.522 rs10153230 chr16:68671741 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.12 0.45 1.76e-14 Ulcerative colitis; CESC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.46 -0.54 1.15e-21 Alzheimer's disease; CESC cis rs2050392 0.517 rs2489847 chr10:30743673 G/A cg25182066 chr10:30743637 MAP3K8 -0.56 -8.23 -0.45 8.31e-15 Inflammatory bowel disease; CESC cis rs10744422 0.925 rs2292132 chr12:123332834 T/C cg25930673 chr12:123319894 HIP1R -0.72 -5.73 -0.33 2.79e-8 Schizophrenia; CESC cis rs8060686 0.858 rs10468274 chr16:67922342 C/T cg26727032 chr16:67993705 SLC12A4 -0.65 -9.71 -0.51 2.86e-19 HDL cholesterol;Metabolic syndrome; CESC cis rs5753618 0.554 rs5753648 chr22:31879465 A/G cg13145458 chr22:31556086 RNF185 -0.55 -6.3 -0.36 1.22e-9 Colorectal cancer; CESC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg24503407 chr1:205819492 PM20D1 0.82 13.96 0.65 1.43e-33 Menarche (age at onset); CESC cis rs96067 0.805 rs12033825 chr1:36600311 C/T cg24686825 chr1:36642396 MAP7D1 -0.52 -5.71 -0.33 2.99e-8 Corneal structure; CESC cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg14416269 chr4:6271139 WFS1 0.46 7.83 0.43 1.14e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs473651 0.716 rs548179 chr2:239320505 G/A cg18131467 chr2:239335373 ASB1 0.97 18.44 0.75 2.08e-49 Multiple system atrophy; CESC cis rs965469 1.000 rs2236123 chr20:3305305 C/G cg25506879 chr20:3388711 C20orf194 0.51 5.29 0.31 2.61e-7 IFN-related cytopenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26270066 chr15:43941407 CATSPER2 -0.65 -8.0 -0.44 3.78e-14 Gut microbiome composition (summer); CESC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.31 0.54 3.54e-21 Platelet count; CESC trans rs877282 0.853 rs7092805 chr10:756246 G/A cg22713356 chr15:30763199 NA 1.01 8.95 0.48 6.15e-17 Uric acid levels; CESC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg19077165 chr18:44547161 KATNAL2 -0.55 -7.87 -0.44 9.07e-14 Personality dimensions; CESC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg02034447 chr16:89574710 SPG7 0.52 6.7 0.38 1.26e-10 Multiple myeloma (IgH translocation); CESC cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg12386194 chr3:101231763 SENP7 0.44 5.48 0.32 9.88e-8 Colonoscopy-negative controls vs population controls; CESC cis rs829883 0.902 rs1620317 chr12:98890566 T/C cg25150519 chr12:98850993 NA 0.7 9.64 0.51 4.82e-19 Colorectal adenoma (advanced); CESC cis rs12477438 0.715 rs6724476 chr2:99627316 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs2820292 0.500 rs61824384 chr1:201859213 A/G cg06775570 chr1:201857621 SHISA4 -0.34 -5.46 -0.32 1.07e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs7843479 0.601 rs2306646 chr8:21846586 C/G cg17168535 chr8:21777572 XPO7 0.75 12.27 0.6 1.04e-27 Mean corpuscular volume; CESC cis rs12142240 0.698 rs56130131 chr1:46861306 A/C cg10495392 chr1:46806563 NSUN4 0.56 6.15 0.35 2.91e-9 Menopause (age at onset); CESC cis rs2625529 1.000 rs2625529 chr15:72118777 C/G cg16672083 chr15:72433130 SENP8 0.5 6.75 0.38 9.26e-11 Red blood cell count; CESC cis rs3736485 0.966 rs10851500 chr15:51783820 T/C cg08986416 chr15:51914746 DMXL2 -0.41 -5.24 -0.31 3.24e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7959452 0.570 rs10878964 chr12:69720691 T/G cg20891283 chr12:69753455 YEATS4 0.76 11.16 0.57 5.65e-24 Blood protein levels; CESC cis rs7635838 0.892 rs7372723 chr3:11466511 G/A cg00170343 chr3:11313890 ATG7 0.43 5.7 0.33 3.27e-8 HDL cholesterol; CESC cis rs17376456 0.877 rs10476526 chr5:93461916 G/A cg25358565 chr5:93447407 FAM172A 1.15 11.8 0.59 4.11e-26 Diabetic retinopathy; CESC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg12463550 chr7:65579703 CRCP -0.49 -6.28 -0.36 1.4e-9 Aortic root size; CESC cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg08213375 chr14:104286397 PPP1R13B 0.31 5.22 0.31 3.53e-7 Reticulocyte count; CESC cis rs7086627 0.515 rs11202963 chr10:82210392 A/G cg03267442 chr10:82210566 NA -0.34 -5.63 -0.33 4.55e-8 Post bronchodilator FEV1; CESC cis rs12956009 0.518 rs953291 chr18:44870499 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.75 0.38 9.47e-11 Educational attainment (years of education); CESC cis rs10463316 0.817 rs7709507 chr5:150783349 C/T cg03212797 chr5:150827313 SLC36A1 -0.43 -5.38 -0.31 1.64e-7 Metabolite levels (Pyroglutamine); CESC cis rs7666738 0.609 rs28833816 chr4:98868866 T/C cg05340658 chr4:99064831 C4orf37 0.59 7.46 0.42 1.26e-12 Colonoscopy-negative controls vs population controls; CESC cis rs2860975 0.620 rs2275622 chr10:96827178 T/C cg09036531 chr10:96991505 NA -0.38 -5.27 -0.31 2.85e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg13647721 chr17:30228624 UTP6 0.59 5.3 0.31 2.42e-7 Hip circumference adjusted for BMI; CESC cis rs7107174 1.000 rs11237468 chr11:78072833 A/G cg02023728 chr11:77925099 USP35 0.38 5.34 0.31 2.05e-7 Testicular germ cell tumor; CESC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg06634786 chr22:41940651 POLR3H -0.64 -6.57 -0.37 2.67e-10 Vitiligo; CESC cis rs2841277 0.738 rs1036713 chr14:105396693 C/G cg19901468 chr14:105411992 AHNAK2 0.44 6.01 0.35 6.12e-9 Rheumatoid arthritis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15747848 chr15:40074985 FSIP1 -0.43 -6.06 -0.35 4.69e-9 Gambling; CESC cis rs7267979 0.933 rs2387887 chr20:25427081 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 3e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs6662572 0.703 rs17855317 chr1:46500613 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 5.49 0.32 9.51e-8 Blood protein levels; CESC cis rs899997 1.000 rs11072793 chr15:79006442 C/T cg04896959 chr15:78267971 NA 0.37 5.58 0.32 5.91e-8 Coronary artery disease or large artery stroke; CESC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg22920501 chr2:26401640 FAM59B -0.91 -10.33 -0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.21 -0.3 3.82e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs10779751 0.770 rs11121695 chr1:11229515 G/A cg08854313 chr1:11322531 MTOR -0.74 -8.96 -0.48 6.01e-17 Body mass index; CESC cis rs4595586 0.870 rs2388172 chr12:39290539 A/G cg26384229 chr12:38710491 ALG10B 0.37 5.28 0.31 2.76e-7 Morning vs. evening chronotype; CESC cis rs8014204 0.967 rs1319171 chr14:75334096 G/T cg08847533 chr14:75593920 NEK9 -0.47 -5.88 -0.34 1.25e-8 Caffeine consumption; CESC cis rs637571 0.565 rs633800 chr11:65638719 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.69 -8.63 -0.47 5.76e-16 Eosinophil percentage of white cells; CESC cis rs6582630 0.555 rs11182193 chr12:38474090 C/G cg13010199 chr12:38710504 ALG10B 0.47 6.11 0.35 3.63e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs314370 0.951 rs13226502 chr7:100506381 C/T cg10426581 chr7:100472382 SRRT 0.85 8.22 0.45 9.23e-15 Resting heart rate; CESC cis rs7762018 0.556 rs78864023 chr6:170059755 T/A cg19338460 chr6:170058176 WDR27 -0.98 -8.17 -0.45 1.29e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs950027 0.620 rs1049518 chr15:45653367 G/A cg21132104 chr15:45694354 SPATA5L1 0.66 8.52 0.46 1.22e-15 Response to fenofibrate (adiponectin levels); CESC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg06108461 chr20:60628389 TAF4 -0.76 -11.3 -0.57 1.95e-24 Body mass index; CESC cis rs847577 0.609 rs34320230 chr7:97785500 C/T cg24562669 chr7:97807699 LMTK2 0.82 13.45 0.64 8.74e-32 Breast cancer; CESC cis rs6752107 1.000 rs3792112 chr2:234176609 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.36 5.44 0.32 1.19e-7 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17412974 chr12:80496965 NA -0.61 -7.09 -0.4 1.21e-11 Gut microbiome composition (summer); CESC cis rs6772849 0.830 rs7633674 chr3:128355026 G/A cg16766828 chr3:128327626 NA -0.31 -5.06 -0.3 7.7e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs4975616 0.869 rs455433 chr5:1336243 A/G cg06550200 chr5:1325588 CLPTM1L -0.69 -10.71 -0.55 1.76e-22 Lung cancer; CESC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg03352830 chr11:487213 PTDSS2 0.74 7.24 0.41 4.78e-12 Body mass index; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03818826 chr16:70323689 AARS -0.47 -6.48 -0.37 4.34e-10 Asthma; CESC cis rs6088580 0.524 rs4911437 chr20:33266149 G/T cg07148914 chr20:33460835 GGT7 -0.44 -5.44 -0.32 1.24e-7 Glomerular filtration rate (creatinine); CESC cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.7 -0.43 2.64e-13 Alzheimer's disease; CESC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg12564285 chr5:131593104 PDLIM4 0.4 6.07 0.35 4.37e-9 Breast cancer; CESC cis rs34779708 0.966 rs34630580 chr10:35449228 A/G cg04310649 chr10:35416472 CREM -0.51 -6.23 -0.36 1.78e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg24308560 chr3:49941425 MST1R -0.56 -8.05 -0.44 2.88e-14 Intelligence (multi-trait analysis); CESC cis rs9467711 0.606 rs9358936 chr6:26370657 A/G cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg25913147 chr15:38545284 SPRED1 -0.49 -6.49 -0.37 4.2e-10 Asthma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23409613 chr14:53196849 STYX -0.38 -6.1 -0.35 3.69e-9 Gambling; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg14492347 chr15:85292323 ZNF592 0.48 6.05 0.35 4.93e-9 Tetralogy of Fallot; CESC cis rs5769765 0.671 rs138832 chr22:50178082 A/G cg02269571 chr22:50332266 NA -0.49 -6.19 -0.36 2.27e-9 Schizophrenia; CESC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 9.63 0.51 5.09e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6741892 0.536 rs6761563 chr2:38891406 A/T cg05275752 chr2:38892887 GALM -0.5 -6.83 -0.39 5.66e-11 5-HTT brain serotonin transporter levels; CESC trans rs526821 0.595 rs624478 chr11:55340778 C/G cg15704280 chr7:45808275 SEPT13 -0.53 -6.55 -0.37 2.9e-10 Pediatric bone mineral density (spine); CESC cis rs8070624 0.543 rs8068175 chr17:17874486 C/T cg16928487 chr17:17741425 SREBF1 -0.62 -10.37 -0.54 2.2e-21 Total body bone mineral density; CESC cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg05283184 chr6:79620031 NA -0.43 -6.5 -0.37 3.91e-10 Intelligence (multi-trait analysis); CESC cis rs34375054 0.526 rs117431213 chr12:125675271 C/G cg25124228 chr12:125621409 AACS -0.53 -6.26 -0.36 1.56e-9 Post bronchodilator FEV1/FVC ratio; CESC cis rs7223966 1.000 rs6504169 chr17:61709145 A/G cg11494091 chr17:61959527 GH2 0.38 5.16 0.3 4.92e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg18404041 chr3:52824283 ITIH1 -0.4 -6.73 -0.38 1.07e-10 Bipolar disorder; CESC cis rs9303401 0.614 rs34941454 chr17:57102742 T/G cg10487724 chr17:56770010 TEX14;RAD51C 0.9 11.27 0.57 2.59e-24 Cognitive test performance; CESC cis rs3126085 0.935 rs12729662 chr1:152185750 G/A cg03465714 chr1:152285911 FLG 0.43 5.04 0.3 8.56e-7 Atopic dermatitis; CESC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg18876405 chr7:65276391 NA -0.44 -5.86 -0.34 1.36e-8 Aortic root size; CESC cis rs7772486 0.790 rs4896852 chr6:146284621 T/C cg23711669 chr6:146136114 FBXO30 -0.93 -13.53 -0.64 4.58e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg03647317 chr4:187891568 NA -0.39 -5.83 -0.34 1.57e-8 Lobe attachment (rater-scored or self-reported); CESC trans rs5756813 0.688 rs56114444 chr22:38123364 C/T cg19894588 chr14:64061835 NA -0.65 -7.47 -0.42 1.13e-12 Optic cup area;Vertical cup-disc ratio; CESC cis rs1003719 0.715 rs2835658 chr21:38565201 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.08 -0.44 2.33e-14 Eye color traits; CESC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg15147215 chr3:52552868 STAB1 -0.32 -5.39 -0.31 1.53e-7 Electroencephalogram traits; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg07146535 chr1:63782988 NA -0.5 -6.13 -0.35 3.23e-9 Thyroid stimulating hormone; CESC cis rs9916302 0.904 rs57399933 chr17:37551189 A/G cg15445000 chr17:37608096 MED1 -0.41 -6.74 -0.38 9.67e-11 Glomerular filtration rate (creatinine); CESC trans rs11098499 0.599 rs3864142 chr4:120266191 A/T cg25214090 chr10:38739885 LOC399744 0.59 7.99 0.44 4.13e-14 Corneal astigmatism; CESC cis rs9287719 0.839 rs11683335 chr2:10756665 C/G cg02196655 chr2:10830764 NOL10 -0.36 -5.53 -0.32 7.69e-8 Prostate cancer; CESC cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg00409905 chr10:38381863 ZNF37A -0.45 -6.0 -0.35 6.61e-9 Extrinsic epigenetic age acceleration; CESC cis rs8111998 0.826 rs59427371 chr19:22766462 C/T cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs7824557 0.564 rs2572404 chr8:11199584 A/G cg21775007 chr8:11205619 TDH 0.52 7.53 0.42 7.81e-13 Retinal vascular caliber; CESC cis rs9811920 0.928 rs9865713 chr3:99870299 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.4 5.22 0.31 3.59e-7 Axial length; CESC cis rs941873 0.868 rs7898 chr10:81114959 C/T cg09469691 chr10:81107165 PPIF 0.55 7.6 0.42 5.14e-13 Height; CESC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg07256732 chr16:621771 PIGQ -0.32 -5.62 -0.33 4.94e-8 Height; CESC trans rs9650657 0.513 rs4841459 chr8:10782442 A/C cg15556689 chr8:8085844 FLJ10661 -0.56 -7.04 -0.4 1.65e-11 Neuroticism; CESC cis rs7590720 0.819 rs6435931 chr2:216892754 C/G cg12620499 chr2:216877984 MREG 0.91 14.08 0.65 5.37e-34 Alcohol dependence; CESC cis rs3857536 0.785 rs6455089 chr6:66944733 A/C cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.78 0.38 7.61e-11 Platelet count; CESC cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg10523679 chr1:76189770 ACADM 0.71 8.42 0.46 2.39e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1707322 0.721 rs12049027 chr1:46118184 A/T cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.58 0.32 5.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2072732 0.904 rs72629496 chr1:2953143 G/A cg15211996 chr1:2936768 ACTRT2 0.35 5.05 0.3 8.22e-7 Plateletcrit; CESC cis rs9814567 1.000 rs9834755 chr3:134206845 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.46 -6.37 -0.36 8.36e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6500395 1.000 rs1558816 chr16:48704868 T/A cg04672837 chr16:48644449 N4BP1 -0.51 -6.43 -0.37 6.05e-10 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09782746 chr12:132553998 EP400 -0.54 -6.38 -0.36 7.92e-10 Gut microbiome composition (summer); CESC cis rs7131987 0.675 rs3847678 chr12:29551560 A/C cg09582351 chr12:29534625 ERGIC2 0.32 5.2 0.3 3.93e-7 QT interval; CESC cis rs35849525 0.814 rs35491931 chr3:49993462 T/A cg24110177 chr3:50126178 RBM5 -0.43 -5.1 -0.3 6.39e-7 Intelligence (multi-trait analysis); CESC cis rs72781680 0.898 rs7569424 chr2:24036222 A/G cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg25072359 chr17:41440525 NA 0.44 5.83 0.34 1.64e-8 Menopause (age at onset); CESC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg26314531 chr2:26401878 FAM59B -0.62 -7.07 -0.4 1.37e-11 Gut microbiome composition (summer); CESC cis rs8002861 0.905 rs6561150 chr13:44460470 C/T cg19180546 chr13:44453867 C13orf31;CCDC122 0.49 6.18 0.35 2.39e-9 Leprosy; CESC cis rs60843830 0.964 rs7584915 chr2:264227 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.89 12.39 0.61 4.07e-28 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs2180341 1.000 rs7756336 chr6:127650299 T/C cg24812749 chr6:127587940 RNF146 1.07 15.4 0.69 1.16e-38 Breast cancer; CESC cis rs3008870 0.755 rs1121824 chr1:67475616 C/A cg08660285 chr1:67390436 MIER1;WDR78 0.62 8.04 0.44 3.01e-14 Lymphocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25009451 chr14:65006716 HSPA2 -0.6 -6.89 -0.39 4.1e-11 Gut microbiome composition (summer); CESC cis rs2197308 0.765 rs12370231 chr12:37917881 T/C cg26384229 chr12:38710491 ALG10B 0.74 10.89 0.56 4.4e-23 Morning vs. evening chronotype; CESC cis rs4835473 0.897 rs6835827 chr4:144633956 A/G cg25736465 chr4:144833511 NA 0.39 6.03 0.35 5.47e-9 Immature fraction of reticulocytes; CESC cis rs9815354 0.638 rs73075241 chr3:42058045 C/T cg03022575 chr3:42003672 ULK4 0.76 6.84 0.39 5.6e-11 Pulse pressure;Diastolic blood pressure; CESC cis rs9611565 0.500 rs10775759 chr22:42088158 T/C cg03806693 chr22:41940476 POLR3H 1.03 12.23 0.6 1.39e-27 Vitiligo; CESC cis rs7633770 0.786 rs1402148 chr3:46678295 C/T cg11219411 chr3:46661640 NA 0.32 5.14 0.3 5.43e-7 Coronary artery disease; CESC cis rs36051895 0.658 rs10974912 chr9:5010885 A/C cg02405213 chr9:5042618 JAK2 -0.49 -5.41 -0.32 1.42e-7 Pediatric autoimmune diseases; CESC cis rs7726839 0.561 rs72703058 chr5:584519 G/A cg09021430 chr5:549028 NA -0.43 -5.76 -0.33 2.29e-8 Obesity-related traits; CESC cis rs11792861 0.926 rs77567374 chr9:111835034 T/C cg13535736 chr9:111863775 C9orf5 -0.52 -6.86 -0.39 4.94e-11 Menarche (age at onset); CESC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg14820908 chr5:178986412 RUFY1 -0.46 -6.88 -0.39 4.4e-11 Lung cancer; CESC cis rs887829 0.569 rs2008595 chr2:234637192 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -6.23 -0.36 1.77e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg08888203 chr3:10149979 C3orf24 0.54 7.15 0.4 8.57e-12 Alzheimer's disease; CESC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg17143192 chr8:8559678 CLDN23 0.71 7.92 0.44 6.78e-14 Obesity-related traits; CESC cis rs77741769 0.571 rs11611087 chr12:121267126 C/T cg02419362 chr12:121203948 SPPL3 0.33 5.33 0.31 2.09e-7 Mean corpuscular volume; CESC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg25036284 chr2:26402008 FAM59B -0.58 -6.44 -0.37 5.66e-10 Gut microbiome composition (summer); CESC trans rs1814175 0.645 rs1963215 chr11:49931486 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.07 0.3 7.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1018836 0.812 rs10808619 chr8:91622916 A/T cg16814680 chr8:91681699 NA -0.71 -10.77 -0.55 1.15e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs11864453 0.749 rs7192730 chr16:72124219 T/C cg16558253 chr16:72132732 DHX38 -0.56 -8.7 -0.47 3.62e-16 Fibrinogen levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02865818 chr5:167719214 WWC1 -0.48 -6.18 -0.35 2.38e-9 Gut microbiota (bacterial taxa); CESC cis rs9303401 0.659 rs17822837 chr17:56737838 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.99 11.25 0.57 2.97e-24 Cognitive test performance; CESC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg17971929 chr21:40555470 PSMG1 0.98 13.49 0.64 6.2e-32 Cognitive function; CESC cis rs3733585 0.699 rs62294332 chr4:9959989 T/C cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03360920 chr6:159421029 RSPH3 -0.43 -6.21 -0.36 2.02e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25834275 chr19:3359809 NFIC -0.49 -6.31 -0.36 1.14e-9 Gut microbiota (bacterial taxa); CESC cis rs4595586 0.545 rs925827 chr12:39364307 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.42 0.41 1.6e-12 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18336435 chr15:60884637 RORA 0.56 6.74 0.38 9.77e-11 Gut microbiome composition (summer); CESC cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg17971929 chr21:40555470 PSMG1 0.78 7.76 0.43 1.85e-13 Cognitive function; CESC cis rs7605378 1.000 rs797163 chr2:200696387 G/A cg23649088 chr2:200775458 C2orf69 0.5 6.7 0.38 1.24e-10 Osteoporosis; CESC cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg06212747 chr3:49208901 KLHDC8B 0.67 8.99 0.48 4.66e-17 Parkinson's disease; CESC cis rs36051895 0.632 rs7469563 chr9:5139489 C/T cg02405213 chr9:5042618 JAK2 -0.54 -6.88 -0.39 4.39e-11 Pediatric autoimmune diseases; CESC cis rs4899260 0.711 rs194716 chr14:69294467 C/A cg03189333 chr14:69283534 NA 0.47 5.13 0.3 5.5e-7 Celiac disease; CESC cis rs3096299 0.748 rs2965822 chr16:89444677 A/T cg08822215 chr16:89438651 ANKRD11 -0.38 -5.64 -0.33 4.37e-8 Multiple myeloma (IgH translocation); CESC cis rs2806561 0.828 rs604030 chr1:23518227 T/C cg12483005 chr1:23474871 LUZP1 0.39 6.04 0.35 5.16e-9 Height; CESC cis rs3617 0.625 rs56019197 chr3:52874753 T/C cg07507251 chr3:52567010 NT5DC2 -0.31 -5.38 -0.31 1.61e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC trans rs853679 0.607 rs17763089 chr6:27835218 G/A cg21479132 chr6:26055353 NA 0.81 6.09 0.35 4.04e-9 Depression; CESC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg05368731 chr17:41323189 NBR1 0.77 10.67 0.55 2.44e-22 Menopause (age at onset); CESC cis rs8062405 1.000 rs12444171 chr16:28845251 G/A cg08761264 chr16:28874980 SH2B1 -0.46 -5.72 -0.33 2.9e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02102644 chr17:35969361 SYNRG 0.57 6.7 0.38 1.26e-10 Gut microbiome composition (summer); CESC cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.91 10.21 0.53 7.64e-21 Mean platelet volume; CESC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg12334488 chr2:20871173 GDF7 -0.38 -5.61 -0.33 5.05e-8 Abdominal aortic aneurysm; CESC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.82 8.2 0.45 1.06e-14 Platelet count; CESC cis rs12765878 0.967 rs10883941 chr10:105650782 C/T cg24587175 chr10:105670608 OBFC1 0.32 5.36 0.31 1.81e-7 Coronary artery disease; CESC cis rs113835537 0.529 rs2276406 chr11:66283257 C/T cg24851651 chr11:66362959 CCS 0.45 5.55 0.32 6.92e-8 Airway imaging phenotypes; CESC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -7.04 -0.4 1.69e-11 Extrinsic epigenetic age acceleration; CESC cis rs9399135 0.967 rs6908512 chr6:135367757 A/G cg22676075 chr6:135203613 NA 0.5 7.06 0.4 1.49e-11 Red blood cell count; CESC cis rs5769765 0.773 rs9616378 chr22:50311973 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.18 -0.35 2.39e-9 Schizophrenia; CESC cis rs17641971 0.645 rs10504073 chr8:50024944 C/T cg00325661 chr8:49890786 NA 0.38 5.38 0.31 1.62e-7 Blood metabolite levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03613717 chr10:121356708 TIAL1 -0.45 -6.34 -0.36 9.69e-10 Gambling; CESC cis rs6598955 0.671 rs17163746 chr1:26564230 C/A cg19743891 chr1:26644573 UBXN11;CD52 0.38 5.44 0.32 1.21e-7 Obesity-related traits; CESC cis rs12449000 1 rs12449000 chr16:89872970 T/C cg21285383 chr16:89894308 SPIRE2 0.34 6.2 0.36 2.17e-9 Schizophrenia; CESC cis rs1808579 0.804 rs1652376 chr18:21109466 A/C cg14672496 chr18:21087552 C18orf8 -0.39 -5.76 -0.33 2.3e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs55788414 0.651 rs2317121 chr16:81182826 T/G cg06400318 chr16:81190750 PKD1L2 -0.58 -6.67 -0.38 1.44e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.38 0.31 1.66e-7 Tonsillectomy; CESC cis rs561341 0.714 rs7218466 chr17:30263314 A/G cg19193384 chr17:30244184 NA -0.48 -5.51 -0.32 8.41e-8 Hip circumference adjusted for BMI; CESC cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg15017067 chr4:17643749 FAM184B 0.44 6.31 0.36 1.17e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1062177 0.855 rs6896664 chr5:151265274 A/G cg12924095 chr5:151150029 G3BP1 0.39 5.51 0.32 8.52e-8 Preschool internalizing problems; CESC cis rs2635047 0.638 rs28718304 chr18:44632830 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.56 0.32 6.58e-8 Educational attainment; CESC cis rs1577917 1.000 rs34622557 chr6:86630852 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -5.53 -0.32 7.75e-8 Response to antipsychotic treatment; CESC cis rs7680126 0.596 rs10805364 chr4:10275518 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -5.2 -0.3 4e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg04287289 chr16:89883240 FANCA -0.49 -5.98 -0.34 7.18e-9 Vitiligo; CESC cis rs939574 1.000 rs1024131 chr2:220117458 G/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 7.49 0.42 1.02e-12 Platelet distribution width; CESC cis rs6540559 0.546 rs735694 chr1:210034029 T/C cg25204440 chr1:209979598 IRF6 0.67 6.11 0.35 3.54e-9 Cleft lip with or without cleft palate; CESC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg23018236 chr17:30244563 NA -0.51 -5.54 -0.32 7.41e-8 Hip circumference adjusted for BMI; CESC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.47 6.15 0.35 2.88e-9 Personality dimensions; CESC cis rs7937682 0.924 rs10891283 chr11:111527672 A/G cg09085632 chr11:111637200 PPP2R1B -1.0 -16.56 -0.71 9.02e-43 Primary sclerosing cholangitis; CESC cis rs10504229 0.636 rs114725691 chr8:58054292 C/T cg24829409 chr8:58192753 C8orf71 -0.51 -6.4 -0.37 7.21e-10 Developmental language disorder (linguistic errors); CESC cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg01475377 chr6:109611718 NA 0.51 8.43 0.46 2.19e-15 Reticulocyte fraction of red cells; CESC cis rs1801251 1.000 rs3817311 chr2:233612557 C/T cg25237894 chr2:233734115 C2orf82 0.45 7.84 0.43 1.1e-13 Coronary artery disease; CESC cis rs17253792 0.749 rs79713967 chr14:56124186 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.65 0.33 4.2e-8 Putamen volume; CESC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs3204270 0.639 rs7215738 chr17:79659847 C/T cg26965718 chr17:79658957 HGS -0.78 -5.81 -0.34 1.77e-8 Dental caries; CESC cis rs6570726 0.846 rs7762536 chr6:145923145 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.61 0.38 2.11e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs7726839 0.540 rs57306627 chr5:597643 T/C cg25482853 chr8:67687455 SGK3 1.04 10.08 0.53 1.87e-20 Obesity-related traits; CESC cis rs12579753 0.917 rs7138895 chr12:82203280 T/G cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs2635047 0.713 rs9304344 chr18:44758665 A/C cg24371990 chr18:44770781 NA -0.41 -6.65 -0.38 1.68e-10 Educational attainment; CESC cis rs11864453 0.647 rs3764314 chr16:72127078 T/C cg01557791 chr16:72042693 DHODH -0.43 -5.57 -0.32 6.39e-8 Fibrinogen levels; CESC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 7.09 0.4 1.22e-11 Bipolar disorder; CESC cis rs8111998 0.826 rs4932776 chr19:22766697 T/C cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs4595586 0.525 rs4768531 chr12:39417754 T/A cg13010199 chr12:38710504 ALG10B 0.43 5.23 0.31 3.49e-7 Morning vs. evening chronotype; CESC cis rs6701037 0.625 rs72719370 chr1:175128536 G/C cg00321850 chr1:175162397 KIAA0040 -0.43 -6.2 -0.36 2.1e-9 Alcohol dependence; CESC trans rs8073060 0.586 rs7214742 chr17:33981969 C/A cg19694781 chr19:47549865 TMEM160 -0.73 -7.32 -0.41 3.05e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7520050 0.966 rs11589562 chr1:46466721 C/T cg03146154 chr1:46216737 IPP 0.46 6.1 0.35 3.74e-9 Red blood cell count;Reticulocyte count; CESC cis rs7647973 0.769 rs6772452 chr3:49040462 A/G cg07636037 chr3:49044803 WDR6 0.91 14.38 0.66 4.69e-35 Menarche (age at onset); CESC cis rs2658782 0.694 rs3019221 chr11:93079700 C/G cg15737290 chr11:93063684 CCDC67 0.58 7.27 0.41 4.11e-12 Pulmonary function decline; CESC trans rs3934047 0.904 rs4448893 chr15:82011355 T/C cg17156767 chr19:30364462 NA 0.39 6.1 0.35 3.74e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs1728785 0.901 rs1170438 chr16:68608256 T/C cg02972257 chr16:68554789 NA -0.6 -6.82 -0.39 6.33e-11 Ulcerative colitis; CESC cis rs863345 0.604 rs12044283 chr1:158463833 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.57e-11 Pneumococcal bacteremia; CESC cis rs9486719 0.857 rs11751075 chr6:97065751 G/A cg06623918 chr6:96969491 KIAA0776 -0.83 -8.95 -0.48 6.52e-17 Migraine;Coronary artery disease; CESC cis rs9303401 0.646 rs9892425 chr17:57241938 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.5 6.5 0.37 3.93e-10 Cognitive test performance; CESC cis rs34779708 0.931 rs7897457 chr10:35386040 A/G cg03585969 chr10:35415529 CREM 0.76 10.09 0.53 1.8e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs684232 0.602 rs35206514 chr17:519859 T/C cg15660573 chr17:549704 VPS53 -0.81 -11.88 -0.59 2.24e-26 Prostate cancer; CESC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg13798912 chr7:905769 UNC84A 0.56 5.57 0.32 6.34e-8 Cerebrospinal P-tau181p levels; CESC cis rs4965006 1.000 rs11246900 chr12:132506784 G/T cg00588090 chr12:132412438 PUS1 0.51 6.45 0.37 5.29e-10 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs1034435 0.547 rs743846 chr22:48900819 C/T cg05992904 chr22:48892994 FAM19A5 -0.46 -6.64 -0.38 1.73e-10 Late-onset Alzheimer's disease; CESC cis rs4925386 0.681 rs2427296 chr20:60927475 G/A cg24112000 chr20:60950667 NA -0.47 -5.89 -0.34 1.14e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg21399703 chr1:247681439 NA 0.56 7.54 0.42 7.34e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.44 -5.09 -0.3 6.7e-7 Schizophrenia; CESC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg07167872 chr1:205819463 PM20D1 0.41 5.92 0.34 9.78e-9 Prostate-specific antigen levels; CESC cis rs3008870 1.000 rs2985818 chr1:67398916 G/A cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg04414720 chr1:150670196 GOLPH3L 0.44 5.83 0.34 1.61e-8 Melanoma; CESC cis rs478304 0.651 rs11604451 chr11:65551710 C/T cg27068330 chr11:65405492 SIPA1 -0.46 -5.55 -0.32 6.97e-8 Acne (severe); CESC cis rs12142240 0.698 rs28578741 chr1:46825176 T/C cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.05 0.53 2.46e-20 Platelet count; CESC cis rs13191362 0.507 rs2023038 chr6:163119280 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.48 -5.76 -0.33 2.32e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg25036284 chr2:26402008 FAM59B -0.57 -6.51 -0.37 3.78e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.46 0.46 1.8e-15 Colonoscopy-negative controls vs population controls; CESC cis rs5769765 0.778 rs4574208 chr22:50256738 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.41 0.32 1.38e-7 Schizophrenia; CESC cis rs1568889 1.000 rs1568889 chr11:28009463 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 6.64 0.38 1.74e-10 Bipolar disorder; CESC cis rs929596 0.785 rs6747843 chr2:234664354 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.67 -8.3 -0.45 5.21e-15 Total bilirubin levels in HIV-1 infection; CESC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg07936489 chr17:37558343 FBXL20 -0.79 -11.12 -0.56 7.81e-24 Urinary metabolites; CESC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.3 0.36 1.21e-9 Menopause (age at onset); CESC trans rs208515 0.592 rs10944862 chr6:66674215 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 11.12 0.56 7.77e-24 Exhaled nitric oxide levels; CESC cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg10523679 chr1:76189770 ACADM 0.8 11.03 0.56 1.58e-23 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9894429 0.646 rs6565609 chr17:79592267 G/A cg18240062 chr17:79603768 NPLOC4 0.54 7.07 0.4 1.39e-11 Eye color traits; CESC cis rs2573652 1.000 rs1469828 chr15:100517210 A/C cg09918751 chr15:100517450 ADAMTS17 -0.43 -8.46 -0.46 1.78e-15 Height; CESC trans rs3942852 0.726 rs1503171 chr11:48175152 T/C cg03929089 chr4:120376271 NA -0.66 -7.19 -0.4 6.48e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs11785400 1.000 rs3802232 chr8:143746701 A/G cg10596483 chr8:143751796 JRK 0.43 5.65 0.33 4.1e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12278653 chr12:31944807 H3F3C -0.59 -6.77 -0.38 8.07e-11 Gut microbiome composition (summer); CESC cis rs3096299 0.566 rs4129126 chr16:89561475 A/C cg16743903 chr16:89593216 SPG7 -0.52 -6.51 -0.37 3.64e-10 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23719950 chr11:63933701 MACROD1 0.53 6.1 0.35 3.75e-9 Gut microbiome composition (summer); CESC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg19717773 chr7:2847554 GNA12 -0.57 -8.24 -0.45 7.9e-15 Height; CESC trans rs2727020 0.521 rs7946190 chr11:49521964 T/A cg15704280 chr7:45808275 SEPT13 0.82 9.96 0.52 4.58e-20 Coronary artery disease; CESC cis rs67478160 0.643 rs12878868 chr14:104233725 G/A cg01849466 chr14:104193079 ZFYVE21 -0.49 -6.84 -0.39 5.57e-11 Schizophrenia; CESC cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg23018236 chr17:30244563 NA -0.53 -5.06 -0.3 7.84e-7 Hip circumference adjusted for BMI; CESC cis rs3806843 0.676 rs1583005 chr5:140031537 G/A cg16179182 chr5:140090404 VTRNA1-1 0.4 5.08 0.3 7.23e-7 Depressive symptoms (multi-trait analysis); CESC cis rs748404 0.578 rs512628 chr15:43618734 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.68 0.47 3.97e-16 Lung cancer; CESC cis rs7927592 0.763 rs10896326 chr11:68234571 T/C cg20283391 chr11:68216788 NA -0.45 -5.58 -0.32 5.81e-8 Total body bone mineral density; CESC cis rs9287719 0.967 rs6750891 chr2:10738563 T/C cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs3026101 0.671 rs7502643 chr17:5297009 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.47 6.23 0.36 1.85e-9 Body mass index; CESC cis rs1552244 0.554 rs2272120 chr3:10046703 C/T cg00149659 chr3:10157352 C3orf10 0.54 6.55 0.37 2.98e-10 Alzheimer's disease; CESC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg05368731 chr17:41323189 NBR1 0.77 10.72 0.55 1.69e-22 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26513519 chr5:623344 CEP72 0.45 6.39 0.37 7.35e-10 Fibrinogen levels; CESC cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg25517755 chr10:38738941 LOC399744 -0.48 -6.26 -0.36 1.5e-9 Extrinsic epigenetic age acceleration; CESC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.32 -5.33 -0.31 2.13e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02592615 chr6:12012261 HIVEP1 0.63 6.62 0.38 2.03e-10 Gut microbiome composition (summer); CESC cis rs904092 0.786 rs1497375 chr4:100161833 T/A cg12011299 chr4:100065546 ADH4 0.54 6.09 0.35 3.89e-9 Alcohol dependence; CESC trans rs11638815 0.954 rs35734713 chr15:83338505 G/C cg25333056 chr10:135107159 TUBGCP2 -0.46 -6.03 -0.35 5.63e-9 Lipoprotein-associated phospholipase A2 activity change in response to statin therapy; CESC cis rs11122272 0.701 rs2474628 chr1:231526000 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs2243480 0.901 rs2949697 chr7:65464236 A/G cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13095091 chr1:17949604 ARHGEF10L -0.48 -6.15 -0.35 2.88e-9 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg06001716 chr17:41278141 BRCA1;NBR2 -0.38 -5.2 -0.3 3.92e-7 Menopause (age at onset); CESC cis rs6714710 0.580 rs6711101 chr2:98379813 G/A cg26665480 chr2:98280029 ACTR1B 0.54 7.64 0.42 3.91e-13 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs933688 1.000 rs332529 chr5:90789470 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.96 9.85 0.52 1.05e-19 Smoking behavior; CESC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg11764359 chr7:65958608 NA 0.98 15.78 0.7 5.36e-40 Aortic root size; CESC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg00129232 chr17:37814104 STARD3 -0.56 -7.02 -0.4 1.82e-11 Glomerular filtration rate (creatinine); CESC cis rs9815354 0.857 rs7634985 chr3:42019565 C/T cg03022575 chr3:42003672 ULK4 -0.48 -5.49 -0.32 9.53e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Depression; CESC cis rs709400 0.628 rs6575984 chr14:103876454 A/G cg12935359 chr14:103987150 CKB 0.48 7.16 0.4 8e-12 Body mass index; CESC cis rs2742234 0.590 rs2503864 chr10:43666767 G/T cg07801480 chr10:43725741 RASGEF1A 0.41 5.24 0.31 3.25e-7 Hirschsprung disease; CESC cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg18512352 chr11:47633146 NA 0.47 6.69 0.38 1.33e-10 Subjective well-being; CESC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg19318889 chr4:1322082 MAEA 0.57 6.92 0.39 3.48e-11 Longevity; CESC cis rs1740073 0.624 rs9472179 chr6:43938931 C/T cg14777908 chr6:43939685 NA -0.37 -5.57 -0.32 6.25e-8 Vascular endothelial growth factor levels; CESC cis rs6546550 0.935 rs2305523 chr2:70039677 G/T cg02498382 chr2:70120550 SNRNP27 0.4 7.01 0.4 1.97e-11 Prevalent atrial fibrillation; CESC cis rs9486715 0.838 rs6928442 chr6:96870118 A/G cg18709589 chr6:96969512 KIAA0776 0.45 6.46 0.37 5.05e-10 Headache; CESC cis rs6964587 0.773 rs13236026 chr7:91885873 A/G cg17063962 chr7:91808500 NA 0.57 7.28 0.41 3.84e-12 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15452590 chr11:607997 PHRF1 -0.74 -8.62 -0.47 6.2e-16 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26996458 chr8:141636297 EIF2C2 -0.54 -6.29 -0.36 1.31e-9 Gut microbiome composition (summer); CESC cis rs9837602 1.000 rs71313585 chr3:99770696 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.51 7.29 0.41 3.59e-12 Breast cancer; CESC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg18252515 chr7:66147081 NA 0.44 5.85 0.34 1.48e-8 Aortic root size; CESC trans rs6445797 0.632 rs17216740 chr3:56685213 A/G cg15444621 chr13:113611794 NA 0.34 6.0 0.35 6.36e-9 Gastritis; CESC cis rs1256061 0.669 rs1256065 chr14:64698932 G/T cg21174375 chr14:64681225 SYNE2 0.49 6.41 0.37 6.78e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg07343612 chr16:622815 PIGQ -0.54 -7.97 -0.44 4.81e-14 Height; CESC cis rs9329289 1.000 rs9329289 chr10:2542389 A/G cg15501526 chr10:2543763 NA 0.64 11.59 0.58 2.2e-25 Age-related hearing impairment; CESC cis rs1559088 1.000 rs7260051 chr19:33550111 C/A cg27124370 chr19:33622961 WDR88 0.42 5.34 0.31 1.99e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg19346786 chr7:2764209 NA -0.46 -6.71 -0.38 1.2e-10 Height; CESC cis rs9796 0.621 rs11858678 chr15:41467932 A/G cg20272979 chr15:41787780 ITPKA 0.34 5.14 0.3 5.35e-7 Menopause (age at onset); CESC cis rs11711311 1.000 rs9827682 chr3:113450251 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.64 8.85 0.48 1.26e-16 IgG glycosylation; CESC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.48 -6.02 -0.35 5.82e-9 Tonsillectomy; CESC cis rs2742234 0.541 rs11238481 chr10:43719286 A/G cg07801480 chr10:43725741 RASGEF1A -0.4 -5.24 -0.31 3.22e-7 Hirschsprung disease; CESC cis rs6728642 0.519 rs4260285 chr2:97570081 A/G cg26665480 chr2:98280029 ACTR1B -0.52 -5.03 -0.3 9.13e-7 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg26335602 chr6:28129616 ZNF389 0.38 5.58 0.32 6.02e-8 Cardiac Troponin-T levels; CESC cis rs992157 0.560 rs10932763 chr2:219085863 G/C cg00012203 chr2:219082015 ARPC2 -0.74 -9.9 -0.52 7.06e-20 Colorectal cancer; CESC cis rs7267979 0.932 rs433352 chr20:25467992 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.78 -14.88 -0.67 8.2e-37 Liver enzyme levels (alkaline phosphatase); CESC cis rs11711311 0.712 rs11718013 chr3:113341661 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.62 0.38 1.99e-10 IgG glycosylation; CESC cis rs3818285 0.544 rs9787456 chr10:111711822 A/G cg00817464 chr10:111662876 XPNPEP1 -0.51 -6.5 -0.37 4.06e-10 Superior crus of antihelix expression; CESC cis rs2282802 0.685 rs6870103 chr5:139692515 G/T cg26211634 chr5:139558579 C5orf32 -0.45 -6.46 -0.37 5.01e-10 Intelligence (multi-trait analysis); CESC cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg09314803 chr17:79180344 AZI1 -0.47 -7.01 -0.4 1.92e-11 Frontotemporal dementia; CESC cis rs12477438 0.501 rs6708878 chr2:99801564 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 12.45 0.61 2.6e-28 Chronic sinus infection; CESC trans rs561341 0.843 rs2028067 chr17:30239698 T/C cg20587970 chr11:113659929 NA -0.74 -9.63 -0.51 5.18e-19 Hip circumference adjusted for BMI; CESC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.65 0.58 1.34e-25 Alzheimer's disease; CESC cis rs1953600 0.805 rs2819947 chr10:81947757 T/C cg00277334 chr10:82204260 NA 0.46 6.44 0.37 5.54e-10 Sarcoidosis; CESC cis rs3026101 0.671 rs56300366 chr17:5297839 T/G cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.82 0.34 1.74e-8 Body mass index; CESC cis rs12142240 0.698 rs67200518 chr1:46835777 T/C cg00530320 chr1:46809349 NSUN4 0.6 8.07 0.44 2.4e-14 Menopause (age at onset); CESC cis rs2180341 0.694 rs2875972 chr6:127585522 T/C cg24812749 chr6:127587940 RNF146 0.86 11.85 0.59 2.85e-26 Breast cancer; CESC cis rs4810479 0.513 rs3746506 chr20:44586036 G/A cg00125455 chr20:44574271 PCIF1 0.31 5.13 0.3 5.7e-7 Metabolite levels; CESC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg25517755 chr10:38738941 LOC399744 0.45 5.9 0.34 1.09e-8 Extrinsic epigenetic age acceleration; CESC cis rs11630290 0.736 rs6494440 chr15:64145709 C/T cg12036633 chr15:63758958 NA 0.57 5.9 0.34 1.1e-8 Iris characteristics; CESC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg06420487 chr17:61919686 SMARCD2 0.47 5.66 0.33 3.87e-8 Height; CESC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg10691866 chr7:65817282 TPST1 0.33 5.5 0.32 8.83e-8 Aortic root size; CESC cis rs4780401 0.609 rs8047190 chr16:11807097 T/C cg01061890 chr16:11836724 TXNDC11 -0.56 -7.59 -0.42 5.59e-13 Rheumatoid arthritis; CESC cis rs853679 0.599 rs149949 chr6:28011516 T/C cg18032046 chr6:28092343 ZSCAN16 -0.68 -5.25 -0.31 3.14e-7 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06529459 chr11:67397595 NUDT8 0.67 7.45 0.42 1.29e-12 Gut microbiome composition (summer); CESC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg03351412 chr1:154909251 PMVK 0.66 8.89 0.48 9.97e-17 Prostate cancer; CESC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg18876405 chr7:65276391 NA -0.54 -7.59 -0.42 5.49e-13 Aortic root size; CESC cis rs9400271 0.632 rs9374071 chr6:109588681 T/C cg01475377 chr6:109611718 NA -0.46 -7.18 -0.4 7.24e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs7089973 0.604 rs11196932 chr10:116584386 C/T cg03647239 chr10:116582469 FAM160B1 0.42 5.13 0.3 5.48e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs3820928 0.874 rs13423046 chr2:227901805 G/T cg11843606 chr2:227700838 RHBDD1 -0.5 -6.55 -0.37 3.03e-10 Pulmonary function; CESC cis rs854765 0.505 rs4924832 chr17:17897739 A/G cg04398451 chr17:18023971 MYO15A -0.65 -9.26 -0.49 7.33e-18 Total body bone mineral density; CESC cis rs858239 0.570 rs10271613 chr7:23162586 G/A cg23682824 chr7:23144976 KLHL7 0.55 7.71 0.43 2.59e-13 Cerebrospinal fluid biomarker levels; CESC cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg18904891 chr8:8559673 CLDN23 0.72 8.1 0.45 2.05e-14 Obesity-related traits; CESC trans rs7839040 0.698 rs10107284 chr8:82921199 C/T cg14472086 chr9:107730925 NA -0.46 -6.12 -0.35 3.3e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs6964587 1.000 rs35653487 chr7:91745441 C/G cg17063962 chr7:91808500 NA 0.58 8.02 0.44 3.33e-14 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00360757 chr4:49526009 NA -0.53 -6.24 -0.36 1.75e-9 Gut microbiome composition (summer); CESC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg23982607 chr1:1823379 GNB1 -0.38 -5.41 -0.32 1.42e-7 Body mass index; CESC cis rs35955747 0.902 rs5997929 chr22:31664032 C/T cg25791279 chr22:32026902 PISD -0.49 -5.87 -0.34 1.32e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs8014204 1.000 rs8014374 chr14:75322914 G/A cg26191576 chr14:75389716 RPS6KL1 0.37 5.36 0.31 1.85e-7 Caffeine consumption; CESC cis rs593982 1.000 rs72922786 chr11:65562852 G/C cg08755490 chr11:65554678 OVOL1 -1.13 -10.79 -0.55 1.01e-22 Atopic dermatitis; CESC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.55 0.37 2.91e-10 Prudent dietary pattern; CESC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg19592336 chr6:28129416 ZNF389 0.48 7.07 0.4 1.41e-11 Cardiac Troponin-T levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27317242 chr8:23145699 R3HCC1 0.63 7.13 0.4 9.3e-12 Gut microbiome composition (summer); CESC cis rs10484885 0.824 rs112817281 chr6:90555658 G/A cg13799429 chr6:90582589 CASP8AP2 -0.79 -7.7 -0.43 2.63e-13 QRS interval (sulfonylurea treatment interaction); CESC cis rs9303401 0.921 rs34102441 chr17:56877414 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.74 9.58 0.51 7.58e-19 Cognitive test performance; CESC cis rs910316 0.875 rs12588099 chr14:75594462 A/T cg08847533 chr14:75593920 NEK9 0.98 18.89 0.76 5.34e-51 Height; CESC cis rs7089973 0.934 rs12771956 chr10:116576228 C/G cg23260525 chr10:116636907 FAM160B1 0.36 5.72 0.33 2.81e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg16325326 chr1:53192061 ZYG11B 0.63 9.34 0.5 4.18e-18 Monocyte count; CESC cis rs17376456 1.000 rs6867042 chr5:93555761 C/T cg21475434 chr5:93447410 FAM172A 0.89 7.33 0.41 2.76e-12 Diabetic retinopathy; CESC cis rs561341 1.000 rs484175 chr17:30309041 G/A cg12193833 chr17:30244370 NA -0.7 -6.49 -0.37 4.19e-10 Hip circumference adjusted for BMI; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22198823 chr11:66394098 RBM14 -0.43 -6.0 -0.35 6.39e-9 Gut microbiota (bacterial taxa); CESC cis rs2506889 0.553 rs17035189 chr1:10597024 A/G cg07384165 chr1:10488281 NA -0.54 -7.73 -0.43 2.19e-13 Breast cancer; CESC cis rs225245 0.755 rs8078905 chr17:34009029 T/C cg05299278 chr17:33885742 SLFN14 0.4 5.69 0.33 3.37e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs4523957 0.713 rs9906500 chr17:2129210 C/A cg16513277 chr17:2031491 SMG6 -0.63 -8.76 -0.47 2.43e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg21782813 chr7:2030301 MAD1L1 0.49 6.93 0.39 3.13e-11 Bipolar disorder and schizophrenia; CESC cis rs8020095 0.571 rs12588821 chr14:67424500 G/C cg19548862 chr14:67692701 FAM71D -0.49 -5.98 -0.35 7.01e-9 Depression (quantitative trait); CESC cis rs2414059 0.518 rs56398519 chr15:50773432 A/G cg05456662 chr15:50716270 USP8 -0.4 -5.48 -0.32 1.01e-7 QT interval; CESC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg27170947 chr2:26402098 FAM59B 0.72 7.36 0.41 2.28e-12 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs2276868 chr3:40498845 C/T cg09455208 chr3:40491958 NA -0.47 -8.27 -0.45 6.35e-15 Renal cell carcinoma; CESC cis rs911555 0.723 rs2273701 chr14:103923225 G/T cg12935359 chr14:103987150 CKB 0.65 9.62 0.51 5.7e-19 Intelligence (multi-trait analysis); CESC cis rs7481584 0.624 rs12417389 chr11:3035304 G/C cg25174290 chr11:3078921 CARS -0.44 -6.02 -0.35 5.88e-9 Calcium levels; CESC cis rs3806843 0.733 rs801181 chr5:140092814 C/T cg16179182 chr5:140090404 VTRNA1-1 0.39 5.22 0.31 3.57e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6582630 0.519 rs11181294 chr12:38312787 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs7551222 0.752 rs11240756 chr1:204482594 C/T cg20240347 chr1:204465584 NA -0.28 -5.61 -0.33 5.15e-8 Schizophrenia; CESC trans rs7945705 0.935 rs2568062 chr11:8887945 A/G cg10637292 chr12:52960529 KRT74 0.35 6.11 0.35 3.45e-9 Hemoglobin concentration; CESC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg25405998 chr7:65216604 CCT6P1 0.52 5.71 0.33 3e-8 Aortic root size; CESC cis rs3845702 0.736 rs259811 chr2:180787801 C/T cg01881094 chr2:180872142 CWC22 -1.15 -9.71 -0.51 2.8e-19 Schizophrenia; CESC cis rs7103648 0.864 rs10742802 chr11:47432725 T/G cg20307385 chr11:47447363 PSMC3 0.97 16.84 0.72 9.04e-44 Diastolic blood pressure;Systolic blood pressure; CESC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.53 0.42 8.04e-13 Prudent dietary pattern; CESC cis rs2742417 0.603 rs2742455 chr3:45767116 A/G cg04837898 chr3:45731254 SACM1L -0.47 -6.17 -0.35 2.54e-9 Response to anti-depressant treatment in major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08744097 chr16:1550264 TELO2 -0.61 -6.92 -0.39 3.47e-11 Gut microbiome composition (summer); CESC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg19626725 chr5:178986131 RUFY1 0.36 5.58 0.32 6.06e-8 Lung cancer; CESC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg13206674 chr6:150067644 NUP43 0.46 6.52 0.37 3.5e-10 Lung cancer; CESC cis rs6456156 0.586 rs13195158 chr6:167481392 G/A cg23791538 chr6:167370224 RNASET2 -0.51 -6.46 -0.37 4.98e-10 Primary biliary cholangitis; CESC cis rs12681366 0.537 rs2919667 chr8:95465202 C/G cg13257157 chr8:95487014 RAD54B 0.45 5.47 0.32 1.05e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs17052344 0.582 rs111876736 chr17:21747067 A/G cg18423549 chr17:21743878 NA -0.68 -9.74 -0.51 2.31e-19 Cutaneous psoriasis; CESC cis rs2730245 0.528 rs1188954 chr7:158691417 G/A cg24397884 chr7:158709396 WDR60 0.73 11.08 0.56 1.11e-23 Height; CESC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg10792982 chr14:105748885 BRF1 0.4 5.35 0.31 1.86e-7 Mean platelet volume;Platelet distribution width; CESC cis rs763121 0.853 rs5757234 chr22:39072686 C/T cg06022373 chr22:39101656 GTPBP1 0.94 18.23 0.75 1.15e-48 Menopause (age at onset); CESC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.14 0.4 9.11e-12 Bipolar disorder; CESC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg16049864 chr8:95962084 TP53INP1 0.63 9.82 0.52 1.33e-19 Type 2 diabetes; CESC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg21724239 chr8:58056113 NA 0.58 5.47 0.32 1.06e-7 Developmental language disorder (linguistic errors); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg27613236 chr5:138940718 UBE2D2 0.57 7.24 0.41 4.97e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2014572 0.967 rs8100154 chr19:57765432 A/G cg24459738 chr19:57751996 ZNF805 -0.53 -7.57 -0.42 6.02e-13 Hyperactive-impulsive symptoms; CESC cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg03213289 chr20:61660250 NA 0.38 5.94 0.34 9.08e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1475911 0.708 rs56109792 chr21:43520060 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 -0.52 -7.99 -0.44 4.18e-14 IgG glycosylation; CESC cis rs12586317 0.525 rs10144430 chr14:35433682 T/A cg05294307 chr14:35346193 BAZ1A -0.51 -6.38 -0.36 7.78e-10 Psoriasis; CESC cis rs7511006 0.893 rs5771104 chr22:50651839 C/T cg16473166 chr22:50639996 SELO 0.59 8.31 0.45 5.04e-15 Obesity-related traits; CESC cis rs11039389 1 rs11039389 chr11:47796062 T/C cg20307385 chr11:47447363 PSMC3 -0.51 -6.21 -0.36 2e-9 Neuroticism; CESC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10075284 chr2:85765766 MAT2A 0.6 6.24 0.36 1.76e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01395650 chr1:197170599 ZBTB41 0.55 6.16 0.35 2.63e-9 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.7 -8.01 -0.44 3.69e-14 Gut microbiome composition (summer); CESC cis rs6963495 0.818 rs73190189 chr7:105164452 G/A cg19920283 chr7:105172520 RINT1 0.71 6.71 0.38 1.17e-10 Bipolar disorder (body mass index interaction); CESC cis rs2236918 0.710 rs1635507 chr1:242028358 G/T cg17736920 chr1:242011382 EXO1 0.69 9.11 0.49 2.14e-17 Menopause (age at onset); CESC cis rs35110281 0.591 rs230642 chr21:44915533 A/C cg21573476 chr21:45109991 RRP1B 0.36 5.23 0.31 3.43e-7 Mean corpuscular volume; CESC cis rs748404 0.578 rs510108 chr15:43605439 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.61 8.15 0.45 1.45e-14 Lung cancer; CESC cis rs7520050 0.807 rs5021934 chr1:46109304 A/G cg24296786 chr1:45957014 TESK2 0.46 5.97 0.34 7.71e-9 Red blood cell count;Reticulocyte count; CESC cis rs7216064 0.911 rs12449442 chr17:65947640 G/A cg12091567 chr17:66097778 LOC651250 -0.71 -7.12 -0.4 1.01e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2354432 0.546 rs7539416 chr1:146881586 C/T cg25205988 chr1:146714368 CHD1L 0.83 8.93 0.48 7.56e-17 Mitochondrial DNA levels; CESC cis rs80130819 0.515 rs1476608 chr12:48493731 C/T cg24011408 chr12:48396354 COL2A1 0.42 5.36 0.31 1.79e-7 Prostate cancer; CESC cis rs2439831 0.850 rs28707214 chr15:44131623 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.6 0.33 5.26e-8 Lung cancer in ever smokers; CESC cis rs2204008 0.840 rs11181795 chr12:38401129 A/G cg13010199 chr12:38710504 ALG10B 0.48 6.21 0.36 2.03e-9 Bladder cancer; CESC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg19729930 chr2:74357872 NA 0.94 14.25 0.66 1.37e-34 Gestational age at birth (maternal effect); CESC cis rs6867032 1.000 rs61177713 chr5:2017255 G/A cg26168224 chr5:2018326 NA 0.95 19.24 0.76 3.09e-52 Gut microbiome composition (winter); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17900697 chr17:27139003 C17orf63 -0.56 -6.34 -0.36 1e-9 Gut microbiome composition (summer); CESC cis rs7017914 0.935 rs6472551 chr8:71781849 C/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.44 -5.61 -0.33 5.2100000000000003e-08 Bone mineral density; CESC cis rs6426558 0.572 rs2670471 chr1:227454328 T/C cg10327440 chr1:227177885 CDC42BPA 0.5 6.15 0.35 2.87e-9 Neutrophil percentage of white cells; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11382993 chr10:60028551 IPMK;CISD1 0.45 6.06 0.35 4.77e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10416265 0.527 rs7246814 chr19:33538414 G/T cg17764715 chr19:33622953 WDR88 0.59 8.11 0.45 1.94e-14 Bone properties (heel); CESC cis rs524281 1.000 rs472518 chr11:65851902 A/G cg14036092 chr11:66035641 RAB1B 0.54 6.23 0.36 1.87e-9 Electroencephalogram traits; CESC cis rs116095464 0.558 rs13357299 chr5:242211 T/C cg22857025 chr5:266934 NA -1.26 -18.11 -0.74 2.9e-48 Breast cancer; CESC cis rs10129255 0.500 rs988133 chr14:107184963 A/G cg07958169 chr14:107095056 NA -0.54 -8.52 -0.46 1.26e-15 Kawasaki disease; CESC cis rs6540556 0.723 rs6540550 chr1:209925251 A/G cg23920097 chr1:209922102 NA -0.36 -5.2 -0.3 4.02e-7 Red blood cell count; CESC cis rs7216064 0.861 rs73352810 chr17:65875184 G/A cg07042672 chr17:66097459 LOC651250 -0.57 -6.54 -0.37 3.09e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg18876405 chr7:65276391 NA -0.5 -6.84 -0.39 5.39e-11 Aortic root size; CESC cis rs6951245 0.542 rs28460147 chr7:1217192 G/A cg03188948 chr7:1209495 NA 0.72 7.44 0.42 1.45e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2066819 0.892 rs112931321 chr12:56667894 C/T cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.28e-7 Psoriasis vulgaris; CESC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg07701084 chr6:150067640 NUP43 0.43 5.75 0.33 2.51e-8 Lung cancer; CESC cis rs9393777 0.623 rs34313099 chr6:26489607 C/T cg12826209 chr6:26865740 GUSBL1 0.67 7.11 0.4 1.08e-11 Intelligence (multi-trait analysis); CESC trans rs637571 0.544 rs500161 chr11:65695438 C/T cg17712092 chr4:129076599 LARP1B 0.79 10.8 0.55 8.7e-23 Eosinophil percentage of white cells; CESC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg18252515 chr7:66147081 NA -0.47 -6.18 -0.35 2.42e-9 Aortic root size; CESC cis rs2439831 0.867 rs16957627 chr15:43642657 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.84 12.1 0.6 4.05e-27 Lung cancer in ever smokers; CESC cis rs6496667 0.779 rs8037260 chr15:91049960 C/T cg13834112 chr15:90361639 NA 0.41 5.38 0.31 1.68e-7 Rheumatoid arthritis; CESC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.53 -0.37 3.29e-10 Parkinson's disease; CESC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg08736216 chr1:53307985 ZYG11A 0.41 6.85 0.39 5.29e-11 Monocyte count; CESC cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg26818010 chr10:134567672 INPP5A -0.81 -10.03 -0.52 2.81e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9430161 0.611 rs2095920 chr1:11033457 T/A cg27631724 chr1:11040367 C1orf127 0.38 6.21 0.36 2.02e-9 Ewing sarcoma; CESC cis rs728616 0.614 rs61859210 chr10:82131468 G/C cg05935833 chr10:81318306 SFTPA2 -0.45 -5.74 -0.33 2.59e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9359856 0.564 rs56281344 chr6:90445393 T/C cg13799429 chr6:90582589 CASP8AP2 -0.61 -5.81 -0.34 1.78e-8 Bipolar disorder; CESC cis rs6831352 0.918 rs34071486 chr4:100051087 A/G cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs7772486 0.875 rs1412080 chr6:146417304 T/C cg23711669 chr6:146136114 FBXO30 0.77 11.23 0.57 3.4e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs12291225 0.585 rs10832242 chr11:14340504 C/T cg19336497 chr11:14380999 RRAS2 0.45 6.75 0.38 9.29e-11 Sense of smell; CESC trans rs7310309 0.830 rs11114200 chr12:80038849 A/C cg02623991 chr19:54926431 TTYH1 -0.41 -6.02 -0.35 5.79e-9 Classic bladder exstrophy; CESC cis rs7208859 0.623 rs8080882 chr17:29081146 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.09 0.6 4.37e-27 Alzheimer's disease; CESC cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg04317338 chr11:64019027 PLCB3 0.5 5.97 0.34 7.53e-9 Platelet count; CESC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.43 5.41 0.32 1.4e-7 Tonsillectomy; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07376846 chr1:203765385 ZC3H11A 0.5 6.74 0.38 9.63e-11 Systemic lupus erythematosus; CESC cis rs704010 0.543 rs10824713 chr10:80835868 C/T cg11504511 chr10:80827333 ZMIZ1;LOC283050 0.47 6.16 0.35 2.68e-9 Breast cancer; CESC cis rs4555082 0.957 rs2816628 chr14:105736134 T/G cg13114125 chr14:105738426 BRF1 -0.64 -8.22 -0.45 9e-15 Mean platelet volume;Platelet distribution width; CESC cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.75 0.51 2.19e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs11098499 0.754 rs1980026 chr4:120251643 C/A cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs11871801 0.881 rs2071046 chr17:40689613 G/C cg21433558 chr17:40837037 CNTNAP1 -0.44 -5.1 -0.3 6.35e-7 Crohn's disease; CESC cis rs4722166 0.630 rs6969258 chr7:22782528 C/T cg13104385 chr7:22767384 IL6 0.48 6.43 0.37 5.96e-10 Lung cancer; CESC cis rs1018836 0.631 rs9987133 chr8:91470730 T/C cg16814680 chr8:91681699 NA -0.52 -6.92 -0.39 3.38e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs12599106 0.707 rs2163977 chr16:34916134 A/G cg18110333 chr6:292329 DUSP22 -0.71 -9.17 -0.49 1.32e-17 Menopause (age at onset); CESC trans rs7395662 0.500 rs7951327 chr11:48925359 C/T cg00717180 chr2:96193071 NA -0.46 -6.16 -0.35 2.75e-9 HDL cholesterol; CESC cis rs7605827 0.930 rs7606850 chr2:15678250 T/C cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 7.2 0.4 6.18e-12 Depression; CESC cis rs4662945 0.525 rs4662951 chr2:130256272 C/T cg05962382 chr2:130345044 NA -0.47 -6.99 -0.39 2.22e-11 Response to cytidine analogues (gemcitabine); CESC cis rs9811920 0.965 rs9849632 chr3:99867211 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.41 5.38 0.31 1.62e-7 Axial length; CESC cis rs7546094 1.000 rs7513716 chr1:113089320 A/T cg22162597 chr1:113214053 CAPZA1 0.37 5.63 0.33 4.59e-8 Platelet distribution width; CESC cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg03213289 chr20:61660250 NA 0.39 6.15 0.35 2.87e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs8170 0.603 rs4808622 chr19:17415457 C/G cg04749549 chr19:17459798 NA -0.35 -5.57 -0.32 6.28e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23057040 chr1:211433972 RCOR3 0.57 6.16 0.35 2.69e-9 Gut microbiome composition (summer); CESC cis rs7551222 0.721 rs1460036 chr1:204527379 A/G cg20240347 chr1:204465584 NA -0.28 -5.53 -0.32 7.6e-8 Schizophrenia; CESC cis rs9649465 0.542 rs616297 chr7:123426949 A/G cg03229431 chr7:123269106 ASB15 0.42 5.73 0.33 2.67e-8 Migraine; CESC cis rs4268898 0.662 rs74470633 chr2:24438712 A/G cg20701182 chr2:24300061 SF3B14 0.68 7.16 0.4 7.75e-12 Asthma; CESC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg10295955 chr4:187884368 NA -1.07 -22.28 -0.81 1.14e-62 Lobe attachment (rater-scored or self-reported); CESC trans rs12615721 0.792 rs714984 chr2:81946577 A/T cg13174197 chr3:52720522 GNL3;PBRM1 0.77 6.21 0.36 2.06e-9 Pulmonary function decline; CESC cis rs2274273 0.935 rs8004787 chr14:55607366 C/T cg04306507 chr14:55594613 LGALS3 0.29 5.79 0.34 2e-8 Protein biomarker; CESC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg06873352 chr17:61820015 STRADA 0.72 12.71 0.62 3.11e-29 Prudent dietary pattern; CESC cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg02297831 chr4:17616191 MED28 0.51 6.26 0.36 1.5e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2243480 0.901 rs1701759 chr7:65470932 G/T cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg19163074 chr7:65112434 INTS4L2 0.46 5.57 0.32 6.37e-8 Aortic root size; CESC cis rs34779708 0.868 rs2384352 chr10:35492832 A/G cg03585969 chr10:35415529 CREM 0.74 9.44 0.5 1.94e-18 Inflammatory bowel disease;Crohn's disease; CESC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg10053473 chr17:62856997 LRRC37A3 0.66 9.22 0.49 9.62e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3749237 0.595 rs12489092 chr3:49550914 G/C cg02487422 chr3:49467188 NICN1 0.56 8.2 0.45 1.07e-14 Resting heart rate; CESC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg13733410 chr7:12443478 VWDE -0.53 -5.47 -0.32 1.02e-7 Coronary artery disease; CESC cis rs116095464 0.558 rs56298907 chr5:283280 C/A cg22857025 chr5:266934 NA -1.32 -14.16 -0.66 2.9e-34 Breast cancer; CESC cis rs2797685 1.000 rs707466 chr1:7861600 C/A cg04725166 chr1:7887271 PER3 -0.45 -6.19 -0.36 2.31e-9 Crohn's disease; CESC cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg00033643 chr7:134001901 SLC35B4 0.41 5.31 0.31 2.34e-7 Mean platelet volume; CESC cis rs4409675 0.576 rs2474470 chr1:28234999 C/T cg23691781 chr1:28212827 C1orf38 0.29 5.81 0.34 1.83e-8 Corneal astigmatism; CESC cis rs28830936 0.966 rs17733613 chr15:41917585 A/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.36 -5.13 -0.3 5.51e-7 Diastolic blood pressure; CESC cis rs1050631 0.564 rs10153377 chr18:33727984 G/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.72e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg17775713 chr3:133465469 TF -0.29 -5.25 -0.31 3.18e-7 Iron status biomarkers (transferrin levels); CESC cis rs826838 1.000 rs6582619 chr12:38729904 A/G cg26384229 chr12:38710491 ALG10B 0.84 14.75 0.67 2.43e-36 Heart rate; CESC cis rs763121 0.706 rs3827356 chr22:39064806 G/T cg06544989 chr22:39130855 UNC84B -0.46 -8.28 -0.45 6.19e-15 Menopause (age at onset); CESC cis rs72781680 0.821 rs72796378 chr2:24167385 G/A cg08917208 chr2:24149416 ATAD2B 0.62 6.11 0.35 3.53e-9 Lymphocyte counts; CESC cis rs1691799 0.867 rs6581677 chr12:66770379 C/G cg16791601 chr12:66731901 HELB -0.74 -13.04 -0.63 2.31e-30 White blood cell count (basophil); CESC cis rs752010 0.746 rs10890146 chr1:42089389 G/A cg12614395 chr1:42085415 HIVEP3 0.3 5.19 0.3 4.24e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs12137294 0.866 rs1172156 chr1:205220087 C/T cg21643547 chr1:205240462 TMCC2 -0.34 -5.49 -0.32 9.58e-8 Red cell distribution width; CESC cis rs9913156 0.748 rs72835619 chr17:4557285 G/A cg19197139 chr17:4613644 ARRB2 0.91 10.39 0.54 1.96e-21 Lymphocyte counts; CESC cis rs6120849 0.617 rs12480442 chr20:33648388 C/G cg06115741 chr20:33292138 TP53INP2 0.53 5.08 0.3 7.23e-7 Protein C levels; CESC cis rs3733585 0.699 rs60045583 chr4:9971950 G/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.53 -0.32 7.54e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11764590 0.694 rs6972969 chr7:2099331 A/G cg21782813 chr7:2030301 MAD1L1 -0.43 -5.44 -0.32 1.24e-7 Neuroticism; CESC cis rs10743315 0.557 rs1552750 chr12:19356505 A/T cg02471346 chr12:19282374 PLEKHA5 0.68 5.15 0.3 4.98e-7 Gut microbiota (bacterial taxa); CESC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 12.85 0.62 1.1e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11252926 0.674 rs11598550 chr10:504778 A/C cg16386425 chr10:429943 DIP2C 0.44 5.46 0.32 1.11e-7 Psychosis in Alzheimer's disease; CESC cis rs9399135 0.967 rs7766189 chr6:135353851 A/C cg22676075 chr6:135203613 NA 0.52 7.36 0.41 2.3e-12 Red blood cell count; CESC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg16325326 chr1:53192061 ZYG11B 0.8 12.75 0.62 2.39e-29 Monocyte count; CESC cis rs447 1.000 rs10263314 chr7:83776972 C/T cg22846510 chr7:83753280 SEMA3A -0.42 -5.07 -0.3 7.48e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7666738 0.830 rs2903152 chr4:99067992 A/G cg05340658 chr4:99064831 C4orf37 0.83 12.82 0.62 1.36e-29 Colonoscopy-negative controls vs population controls; CESC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg23982607 chr1:1823379 GNB1 -0.79 -13.12 -0.63 1.22e-30 Body mass index; CESC cis rs1799949 0.965 rs4793237 chr17:41436595 A/T cg07153921 chr17:41440717 NA -0.41 -5.53 -0.32 7.87e-8 Menopause (age at onset); CESC cis rs6920965 0.583 rs9388456 chr6:126147197 C/T cg05901451 chr6:126070800 HEY2 -0.41 -5.64 -0.33 4.26e-8 High light scatter reticulocyte count; CESC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.34 -0.36 9.93e-10 Schizophrenia; CESC trans rs7839040 0.672 rs9298381 chr8:82926496 T/A cg14472086 chr9:107730925 NA -0.47 -6.03 -0.35 5.53e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs11098499 0.954 rs71629403 chr4:120372567 C/T cg24375607 chr4:120327624 NA 0.48 5.93 0.34 9.24e-9 Corneal astigmatism; CESC cis rs67311347 0.544 rs6599088 chr3:40329288 T/C cg24209194 chr3:40518798 ZNF619 0.38 5.25 0.31 3.05e-7 Renal cell carcinoma; CESC cis rs593982 0.843 rs565267 chr11:65473597 T/C cg08755490 chr11:65554678 OVOL1 1.15 10.31 0.53 3.64e-21 Atopic dermatitis; CESC cis rs8114671 0.562 rs6087643 chr20:33474462 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.17 0.3 4.52e-7 Height; CESC cis rs10465746 0.747 rs10493741 chr1:84388118 G/C cg10977910 chr1:84465055 TTLL7 0.52 7.06 0.4 1.47e-11 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07031794 chr2:26568949 SELI;GPR113 -0.46 -6.01 -0.35 6.08e-9 Fibrinogen levels; CESC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg21644426 chr2:191273491 MFSD6 0.48 6.32 0.36 1.12e-9 Pulse pressure; CESC cis rs34286592 1.000 rs62056375 chr16:29857901 G/A cg27338089 chr16:29820515 MAZ 0.56 5.57 0.32 6.26e-8 Multiple sclerosis; CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg07508260 chr11:111742291 ALG9 0.53 6.18 0.35 2.35e-9 Endometrial cancer; CESC cis rs12410462 0.581 rs113827839 chr1:227547180 C/T cg04117972 chr1:227635322 NA 0.63 5.35 0.31 1.9e-7 Major depressive disorder; CESC cis rs4566357 1.000 rs2396444 chr2:227921314 T/G cg11843606 chr2:227700838 RHBDD1 -0.41 -5.29 -0.31 2.58e-7 Coronary artery disease; CESC cis rs35146811 0.844 rs10281368 chr7:99655897 A/G cg13334819 chr7:99746414 C7orf59 -0.43 -5.13 -0.3 5.61e-7 Coronary artery disease; CESC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg00149659 chr3:10157352 C3orf10 0.72 8.61 0.47 6.41e-16 Alzheimer's disease; CESC trans rs11088226 0.681 rs2833911 chr21:33949629 C/T cg09050820 chr6:167586206 TCP10L2 -0.93 -9.84 -0.52 1.15e-19 Gastritis; CESC cis rs763121 1.000 rs1946990 chr22:38912771 C/T cg06544989 chr22:39130855 UNC84B -0.44 -7.83 -0.43 1.18e-13 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03796655 chr15:89456767 MFGE8 0.56 6.11 0.35 3.51e-9 Gut microbiome composition (summer); CESC cis rs3750965 0.806 rs7107680 chr11:68859894 C/T cg01403660 chr11:68851641 TPCN2 0.41 5.51 0.32 8.44e-8 Hair color; CESC cis rs6088590 0.735 rs6088618 chr20:33409350 G/A cg08999081 chr20:33150536 PIGU 0.65 10.44 0.54 1.35e-21 Coronary artery disease; CESC cis rs9815354 0.670 rs73073238 chr3:42014325 G/C cg03022575 chr3:42003672 ULK4 0.68 6.13 0.35 3.21e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7208859 0.623 rs9915566 chr17:29132158 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.6 -8.35 -0.46 3.87e-15 Personality dimensions; CESC cis rs8027181 0.740 rs8038247 chr15:73096573 A/G cg25632853 chr15:73088954 NA 0.33 5.89 0.34 1.19e-8 Triglyceride levels; CESC cis rs3749237 0.964 rs1799843 chr3:49849723 G/A cg03060546 chr3:49711283 APEH 0.65 7.65 0.43 3.69e-13 Resting heart rate; CESC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg00934597 chr7:893267 UNC84A 0.53 5.41 0.32 1.43e-7 Cerebrospinal P-tau181p levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25682936 chr1:38455768 SF3A3 0.51 6.47 0.37 4.63e-10 Gut microbiota (bacterial taxa); CESC cis rs7580658 0.750 rs4497825 chr2:128061053 A/G cg10021288 chr2:128175891 PROC -0.37 -5.97 -0.34 7.58e-9 Protein C levels; CESC cis rs7432375 0.566 rs835636 chr3:136674500 A/C cg15507776 chr3:136538369 TMEM22 0.63 8.47 0.46 1.77e-15 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs12618769 0.597 rs3769741 chr2:99068204 G/T cg10123293 chr2:99228465 UNC50 0.41 5.5 0.32 8.76e-8 Bipolar disorder; CESC trans rs629535 0.773 rs568159 chr8:70032908 C/G cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC trans rs1814175 0.527 rs10769595 chr11:49638212 A/G cg15704280 chr7:45808275 SEPT13 -0.83 -10.51 -0.54 7.82e-22 Height; CESC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg26354017 chr1:205819088 PM20D1 0.85 13.43 0.64 1.06e-31 Menarche (age at onset); CESC cis rs208520 0.742 rs208454 chr6:66907783 T/C cg07460842 chr6:66804631 NA -0.86 -10.11 -0.53 1.55e-20 Exhaled nitric oxide output; CESC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg15145296 chr3:125709740 NA -0.55 -5.96 -0.34 7.81e-9 Blood pressure (smoking interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13709634 chr11:679709 DEAF1 -0.53 -7.2 -0.4 6.18e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4253772 0.530 rs8140573 chr22:46800363 G/C cg18190219 chr22:46762943 CELSR1 -0.59 -6.12 -0.35 3.28e-9 LDL cholesterol;Cholesterol, total; CESC trans rs208520 0.507 rs3903670 chr6:66812183 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -25.1 -0.84 5.19e-72 Exhaled nitric oxide output; CESC cis rs6570726 0.967 rs1396648 chr6:145785248 C/A cg05347473 chr6:146136440 FBXO30 -0.4 -5.45 -0.32 1.18e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs6433857 0.627 rs1406259 chr2:181522879 T/G cg23363182 chr2:181467187 NA -0.46 -6.26 -0.36 1.58e-9 Body mass index; CESC cis rs10242455 0.702 rs28377312 chr7:98984213 G/A cg18809830 chr7:99032528 PTCD1 -0.83 -5.55 -0.32 7.04e-8 Blood metabolite levels; CESC cis rs854765 0.583 rs12452219 chr17:17829423 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.36 0.36 8.95e-10 Total body bone mineral density; CESC cis rs7208859 0.573 rs8064686 chr17:29134839 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg22143856 chr6:28129313 ZNF389 0.46 5.84 0.34 1.56e-8 Depression; CESC cis rs7659604 0.540 rs10012775 chr4:122676878 T/C cg19671926 chr4:122722719 EXOSC9 0.53 6.7 0.38 1.21e-10 Type 2 diabetes; CESC trans rs61931739 0.500 rs11053268 chr12:34545121 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.74e-12 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20476801 chr6:131949468 MED23 0.6 6.41 0.37 6.65e-10 Gut microbiome composition (summer); CESC cis rs9399135 0.660 rs4646868 chr6:135271946 A/G cg22676075 chr6:135203613 NA 0.51 7.05 0.4 1.52e-11 Red blood cell count; CESC cis rs4906332 1.000 rs12885762 chr14:103882200 C/A cg09975044 chr14:104007538 NA 0.46 6.32 0.36 1.07e-9 Coronary artery disease; CESC cis rs6732160 0.845 rs6546805 chr2:73386115 G/T cg01422370 chr2:73384389 NA 0.42 7.15 0.4 8.33e-12 Intelligence (multi-trait analysis); CESC cis rs4268898 1.000 rs4268898 chr2:24490413 C/T cg20701182 chr2:24300061 SF3B14 -0.42 -5.1 -0.3 6.46e-7 Asthma; CESC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg19592336 chr6:28129416 ZNF389 0.62 8.12 0.45 1.77e-14 Depression; CESC cis rs2243480 1.000 rs7795242 chr7:65390094 T/C cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC cis rs17253792 0.732 rs75796044 chr14:56034128 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.87 0.34 1.27e-8 Putamen volume; CESC cis rs367615 0.537 rs1965670 chr5:108649798 A/T cg17395555 chr5:108820864 NA -0.48 -7.92 -0.44 6.58e-14 Colorectal cancer (SNP x SNP interaction); CESC cis rs1983891 0.742 rs755304 chr6:41552101 T/C cg20194872 chr6:41519635 FOXP4 0.48 6.71 0.38 1.16e-10 Prostate cancer; CESC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg11366901 chr6:160182831 ACAT2 0.64 8.17 0.45 1.24e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs2730245 0.527 rs842695 chr7:158662182 G/A cg24397884 chr7:158709396 WDR60 0.81 8.17 0.45 1.28e-14 Height; CESC cis rs6546550 0.901 rs4144081 chr2:70155482 G/A cg02498382 chr2:70120550 SNRNP27 -0.41 -7.1 -0.4 1.16e-11 Prevalent atrial fibrillation; CESC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.42e-7 Lung cancer; CESC cis rs67478160 0.643 rs12891175 chr14:104274166 T/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.19 -0.4 6.56e-12 Schizophrenia; CESC cis rs854765 0.583 rs9635697 chr17:17870394 T/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.22 0.45 9.43e-15 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17617805 chr17:56595405 MTMR4 -0.73 -7.93 -0.44 5.99e-14 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.9 0.39 3.9e-11 Bipolar disorder; CESC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg06873352 chr17:61820015 STRADA 0.73 12.89 0.62 7.87e-30 Prudent dietary pattern; CESC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.85 11.76 0.59 5.89e-26 Alzheimer's disease; CESC trans rs1814175 0.817 rs1615305 chr11:49895222 T/A cg03929089 chr4:120376271 NA -0.91 -15.66 -0.69 1.37e-39 Height; CESC cis rs4523957 0.788 rs7217687 chr17:2098272 G/C cg16513277 chr17:2031491 SMG6 -0.57 -7.75 -0.43 1.91e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC trans rs2727020 0.930 rs1164686 chr11:49291822 C/T cg03929089 chr4:120376271 NA 0.71 9.26 0.49 7.34e-18 Coronary artery disease; CESC cis rs75804782 0.641 rs60841092 chr2:239349640 G/A cg18131467 chr2:239335373 ASB1 -0.67 -5.66 -0.33 3.93e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs71277158 0.688 rs76146592 chr3:169789234 C/T cg04067573 chr3:169899625 PHC3 0.71 6.99 0.39 2.24e-11 Prostate cancer; CESC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg02574844 chr11:5959923 NA -0.46 -6.5 -0.37 3.99e-10 DNA methylation (variation); CESC cis rs6088590 0.523 rs6088536 chr20:33189106 T/C cg24642439 chr20:33292090 TP53INP2 0.64 8.49 0.46 1.52e-15 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10206887 chr8:22102902 POLR3D;MIR320A 0.63 7.41 0.41 1.66e-12 Gut microbiome composition (summer); CESC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 5.03 0.3 9.02e-7 Electroencephalogram traits; CESC cis rs11690935 0.885 rs6750058 chr2:172786909 G/T cg13550731 chr2:172543902 DYNC1I2 -0.84 -12.29 -0.6 8.81e-28 Schizophrenia; CESC cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 6.44 0.37 5.47e-10 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18170098 chr16:71880032 ATXN1L -0.68 -8.27 -0.45 6.76e-15 Gut microbiome composition (summer); CESC cis rs1400745 0.729 rs28472856 chr14:35332157 C/T cg16230307 chr14:35515116 FAM177A1 0.44 5.17 0.3 4.67e-7 Monocyte count; CESC cis rs1881797 1.000 rs10925062 chr1:247658978 G/C cg05639522 chr1:247681581 NA 0.51 6.43 0.37 5.89e-10 Acute lymphoblastic leukemia (childhood); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10585161 chr5:115420544 COMMD10 0.46 6.49 0.37 4.21e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs870825 0.616 rs2310110 chr4:185647902 G/A cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs2073300 0.609 rs6137915 chr20:23358509 A/G cg12062639 chr20:23401060 NAPB -0.99 -7.93 -0.44 6e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7116495 0.609 rs10736780 chr11:71650241 T/C cg10381502 chr11:71823885 C11orf51 -1.1 -7.6 -0.42 5.21e-13 Severe influenza A (H1N1) infection; CESC cis rs919433 1.000 rs1346649 chr2:198166117 C/A cg10820045 chr2:198174542 NA -0.43 -6.53 -0.37 3.42e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs295140 0.526 rs295114 chr2:201195602 C/T cg23649088 chr2:200775458 C2orf69 0.49 6.51 0.37 3.73e-10 QT interval; CESC cis rs10129255 0.500 rs988134 chr14:107184937 A/G cg07958169 chr14:107095056 NA -0.54 -8.52 -0.46 1.26e-15 Kawasaki disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg21939482 chr7:6388130 C7orf70 0.52 6.9 0.39 3.86e-11 Systemic lupus erythematosus; CESC cis rs796364 0.806 rs77853713 chr2:201006880 A/T cg23649088 chr2:200775458 C2orf69 -0.55 -5.04 -0.3 8.69e-7 Schizophrenia; CESC cis rs2439831 0.850 rs68079546 chr15:44136957 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.66 6.03 0.35 5.4e-9 Lung cancer in ever smokers; CESC cis rs6543140 0.964 rs11886793 chr2:103072220 T/G cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs554111 0.660 rs541464 chr1:21067095 C/T cg04902671 chr1:21058625 SH2D5 -0.43 -5.23 -0.31 3.41e-7 Facial morphology (factor 17, height of vermillion upper lip); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11897034 chr16:22386000 CDR2 0.58 6.45 0.37 5.15e-10 Gut microbiome composition (summer); CESC cis rs854765 0.547 rs4365348 chr17:17912548 C/T cg09796270 chr17:17721594 SREBF1 0.39 5.42 0.32 1.34e-7 Total body bone mineral density; CESC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg06456125 chr7:65229604 NA -0.4 -5.27 -0.31 2.86e-7 Aortic root size; CESC cis rs67478160 0.634 rs2295140 chr14:104216293 C/T cg08213375 chr14:104286397 PPP1R13B 0.46 9.07 0.49 2.69e-17 Schizophrenia; CESC cis rs7216064 0.648 rs61676547 chr17:65892507 G/C cg07042672 chr17:66097459 LOC651250 -0.59 -7.01 -0.4 1.97e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9715521 0.588 rs11731207 chr4:59852246 G/A cg11281224 chr4:60001000 NA -0.51 -7.11 -0.4 1.09e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg26850624 chr5:429559 AHRR -0.48 -6.58 -0.37 2.56e-10 Cystic fibrosis severity; CESC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg06481639 chr22:41940642 POLR3H -0.63 -6.24 -0.36 1.76e-9 Vitiligo; CESC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs4523957 0.788 rs2169357 chr17:2096441 C/T cg16513277 chr17:2031491 SMG6 -0.64 -8.83 -0.48 1.5e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs116095464 0.558 rs28635197 chr5:279071 T/C cg00938859 chr5:1591904 SDHAP3 0.65 7.03 0.4 1.73e-11 Breast cancer; CESC cis rs6598955 0.640 rs1577507 chr1:26547179 C/T cg04990556 chr1:26633338 UBXN11 -0.8 -11.48 -0.58 4.95e-25 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23064501 chr12:42680748 NA 0.44 6.19 0.36 2.32e-9 Fibrinogen levels; CESC trans rs7937682 0.855 rs10891285 chr11:111527775 T/C cg18187862 chr3:45730750 SACM1L 0.48 6.19 0.36 2.22e-9 Primary sclerosing cholangitis; CESC cis rs13108904 0.905 rs1732108 chr4:1276550 C/T cg22903657 chr4:1355424 KIAA1530 0.4 5.5 0.32 8.81e-8 Obesity-related traits; CESC cis rs763121 0.853 rs10135 chr22:39082174 C/T cg06544989 chr22:39130855 UNC84B -0.51 -9.69 -0.51 3.24e-19 Menopause (age at onset); CESC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 6.56 0.37 2.84e-10 Electroencephalogram traits; CESC cis rs1801251 1.000 rs1867778 chr2:233679644 C/T cg25237894 chr2:233734115 C2orf82 -0.44 -7.66 -0.43 3.57e-13 Coronary artery disease; CESC cis rs863345 0.604 rs7518708 chr1:158504274 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg04944784 chr2:26401820 FAM59B -0.9 -10.24 -0.53 5.81e-21 Gut microbiome composition (summer); CESC cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg05347473 chr6:146136440 FBXO30 0.76 9.61 0.51 5.93e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs9902453 1.000 rs7221743 chr17:28407876 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.64 -8.06 -0.44 2.71e-14 Coffee consumption (cups per day); CESC cis rs854765 0.663 rs16960744 chr17:17755259 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.48 -6.84 -0.39 5.41e-11 Total body bone mineral density; CESC cis rs73206853 0.764 rs61117387 chr12:110867725 C/A cg12870014 chr12:110450643 ANKRD13A 0.62 5.09 0.3 6.71e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22315683 chr3:101280662 RG9MTD1 -0.67 -7.84 -0.43 1.09e-13 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs74251568 chr16:89903416 A/C cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC trans rs9325144 0.647 rs61937754 chr12:39060543 T/C cg23762105 chr12:34175262 ALG10 0.46 6.01 0.35 6.05e-9 Morning vs. evening chronotype; CESC cis rs6430585 1.000 rs6732236 chr2:136501509 T/G cg07169764 chr2:136633963 MCM6 1.02 13.21 0.63 5.99e-31 Corneal structure; CESC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg18337363 chr3:52569053 NT5DC2 -0.28 -5.13 -0.3 5.56e-7 Bipolar disorder; CESC trans rs11098499 0.954 rs1480931 chr4:120395809 G/T cg25214090 chr10:38739885 LOC399744 0.7 10.09 0.53 1.78e-20 Corneal astigmatism; CESC trans rs72766638 0.895 rs11795079 chr9:136930134 T/C cg10765909 chr12:53715428 AAAS -0.72 -6.48 -0.37 4.33e-10 Mosquito bite size; CESC cis rs72781680 0.898 rs72790310 chr2:24116716 C/T cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.07e-8 Lymphocyte counts; CESC cis rs9486719 0.895 rs3734238 chr6:96996228 A/T cg06623918 chr6:96969491 KIAA0776 -0.8 -8.3 -0.45 5.39e-15 Migraine;Coronary artery disease; CESC cis rs7605827 0.930 rs13024104 chr2:15603346 T/C cg19274914 chr2:15703543 NA 0.35 6.11 0.35 3.48e-9 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06251129 chr1:155990657 SSR2 0.61 7.29 0.41 3.61e-12 Gut microbiome composition (summer); CESC cis rs4253772 0.530 rs8140573 chr22:46800363 G/C cg09491104 chr22:46646882 C22orf40 -0.5 -5.5 -0.32 8.75e-8 LDL cholesterol;Cholesterol, total; CESC cis rs796364 0.760 rs56285751 chr2:200919836 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18767088 chr21:30670919 BACH1 0.46 6.1 0.35 3.67e-9 Gut microbiota (bacterial taxa); CESC cis rs1878931 0.501 rs42329 chr16:3425524 G/A cg22508957 chr16:3507546 NAT15 0.39 5.6 0.33 5.26e-8 Body mass index (adult); CESC trans rs11098499 0.913 rs56122576 chr4:120129336 A/G cg25214090 chr10:38739885 LOC399744 0.63 8.33 0.46 4.44e-15 Corneal astigmatism; CESC cis rs561341 1.000 rs576985 chr17:30323323 C/T cg12193833 chr17:30244370 NA -0.72 -6.68 -0.38 1.42e-10 Hip circumference adjusted for BMI; CESC cis rs9457247 0.602 rs12208359 chr6:167458455 G/A cg23791538 chr6:167370224 RNASET2 -0.55 -7.17 -0.4 7.51e-12 Crohn's disease; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg01931797 chr11:77899910 KCTD21;USP35 -0.5 -6.12 -0.35 3.27e-9 Lung cancer in ever smokers; CESC cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11608355 0.538 rs10850074 chr12:109800531 T/C cg19025524 chr12:109796872 NA -0.51 -7.14 -0.4 9.08e-12 Neuroticism; CESC cis rs10791097 0.592 rs4936122 chr11:130734264 A/C cg12179176 chr11:130786555 SNX19 0.68 10.0 0.52 3.48e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg00074818 chr8:8560427 CLDN23 0.37 5.34 0.31 2.02e-7 Obesity-related traits; CESC cis rs3859192 0.599 rs2227321 chr17:38171294 G/C cg17344932 chr17:38183730 MED24;SNORD124 0.62 9.31 0.5 5.1e-18 White blood cell count; CESC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.08 -0.4 1.27e-11 Total body bone mineral density; CESC cis rs9914544 1.000 rs8066385 chr17:18761133 C/T cg26378065 chr17:18585709 ZNF286B 0.44 5.49 0.32 9.61e-8 Educational attainment (years of education); CESC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg07677032 chr17:61819896 STRADA 0.44 5.88 0.34 1.21e-8 Prudent dietary pattern; CESC cis rs1348850 0.513 rs6730406 chr2:178492722 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 5.59 0.32 5.57e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4843747 0.671 rs74729706 chr16:88104159 C/T cg06915872 chr16:87998081 BANP 0.44 5.2 0.3 3.99e-7 Menopause (age at onset); CESC cis rs13031619 1.000 rs13031619 chr2:3698371 A/G cg19052272 chr2:3704530 ALLC 0.53 6.87 0.39 4.56e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs9309473 0.898 rs10201159 chr2:73858965 T/C cg20560298 chr2:73613845 ALMS1 -0.53 -6.78 -0.38 7.74e-11 Metabolite levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg01334186 chr1:151372572 PSMB4 0.49 6.74 0.38 9.88e-11 Systemic lupus erythematosus; CESC cis rs4315565 1.000 rs4315565 chr2:69287943 A/G cg12800200 chr2:69260302 ANTXR1 -0.41 -5.91 -0.34 1.04e-8 Height; CESC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg11494091 chr17:61959527 GH2 0.73 12.68 0.61 4.13e-29 Prudent dietary pattern; CESC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.61 0.33 5.09e-8 Bipolar disorder; CESC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg04317338 chr11:64019027 PLCB3 0.8 8.46 0.46 1.83e-15 Mean platelet volume; CESC cis rs6580649 0.941 rs6580651 chr12:48429933 A/T cg24011408 chr12:48396354 COL2A1 -0.42 -5.28 -0.31 2.68e-7 Lung cancer; CESC cis rs4409675 0.576 rs2749119 chr1:28236248 G/A cg23691781 chr1:28212827 C1orf38 0.28 5.59 0.32 5.61e-8 Corneal astigmatism; CESC cis rs6964587 0.933 rs10271174 chr7:91785970 A/G cg17063962 chr7:91808500 NA 0.59 8.24 0.45 7.92e-15 Breast cancer; CESC cis rs1797885 0.934 rs709165 chr3:12514124 A/G cg26432171 chr3:12704882 RAF1 -0.52 -6.71 -0.38 1.21e-10 Immature fraction of reticulocytes; CESC cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg03433033 chr1:76189801 ACADM 0.68 8.23 0.45 8.33e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3015497 0.934 rs2934691 chr14:51121333 C/A cg26011998 chr14:51135199 SAV1 -0.43 -5.49 -0.32 9.62e-8 Mean platelet volume; CESC cis rs11048434 0.736 rs2041624 chr12:9111855 C/G cg23795048 chr12:9217529 LOC144571 0.35 5.35 0.31 1.9e-7 Sjögren's syndrome; CESC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg08886695 chr4:3369023 RGS12 -0.42 -5.82 -0.34 1.72e-8 Serum sulfate level; CESC cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg00409905 chr10:38381863 ZNF37A -0.46 -6.18 -0.35 2.39e-9 Extrinsic epigenetic age acceleration; CESC cis rs7084402 0.967 rs1658460 chr10:60299151 T/G cg07615347 chr10:60278583 BICC1 0.6 9.46 0.5 1.77e-18 Refractive error; CESC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg00166722 chr3:10149974 C3orf24 0.54 6.89 0.39 4.08e-11 Alzheimer's disease; CESC cis rs1059312 0.522 rs3825181 chr12:129279264 G/A cg09035930 chr12:129282057 SLC15A4 -0.52 -6.67 -0.38 1.5e-10 Systemic lupus erythematosus; CESC cis rs6424115 0.830 rs2501425 chr1:24199339 A/C cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC cis rs11122272 0.735 rs2790882 chr1:231532783 A/G cg06096015 chr1:231504339 EGLN1 -0.41 -5.86 -0.34 1.37e-8 Hemoglobin concentration; CESC cis rs10242455 0.702 rs75156180 chr7:98964100 G/A cg25640893 chr7:99214727 ZNF498 0.85 5.5 0.32 9.08e-8 Blood metabolite levels; CESC cis rs6430585 0.583 rs4594504 chr2:136625113 A/C cg07169764 chr2:136633963 MCM6 1.3 20.08 0.78 3.71e-55 Corneal structure; CESC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg23034840 chr1:205782522 SLC41A1 0.68 8.11 0.45 1.88e-14 Menarche (age at onset); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05609414 chr7:39873832 NA -0.41 -6.35 -0.36 9.33e-10 Asthma; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg12427896 chr2:111880694 BCL2L11 0.47 6.37 0.36 8.2e-10 Weight; CESC cis rs10870270 0.913 rs115236491 chr10:133766855 T/G cg08754478 chr10:133766260 PPP2R2D -0.59 -7.62 -0.42 4.57e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs919433 0.783 rs55725278 chr2:198238223 C/T cg03934865 chr2:198174659 NA 0.44 6.27 0.36 1.49e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9902453 0.933 rs9908901 chr17:28469713 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.6 0.42 5.23e-13 Coffee consumption (cups per day); CESC cis rs4950928 0.823 rs7541061 chr1:203163367 G/T cg14085262 chr1:203155938 CHI3L1 0.47 5.26 0.31 3e-7 YKL-40 levels; CESC cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg12373951 chr3:133503437 NA -0.49 -7.29 -0.41 3.65e-12 Iron status biomarkers; CESC cis rs826838 1.000 rs2129627 chr12:38653036 C/T cg13010199 chr12:38710504 ALG10B 0.59 8.31 0.45 4.93e-15 Heart rate; CESC cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg06713675 chr4:122721982 EXOSC9 -0.5 -6.86 -0.39 4.93e-11 Type 2 diabetes; CESC cis rs524023 1.000 rs11602903 chr11:64358241 A/T cg07220939 chr11:64358617 SLC22A12 -0.35 -5.46 -0.32 1.09e-7 Urate levels in obese individuals; CESC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg13607699 chr17:42295918 UBTF 0.57 7.38 0.41 2.07e-12 Total body bone mineral density; CESC cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg03467027 chr4:99064603 C4orf37 0.43 5.42 0.32 1.34e-7 Colonoscopy-negative controls vs population controls; CESC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg15369054 chr17:80825471 TBCD -0.46 -6.23 -0.36 1.84e-9 Breast cancer; CESC cis rs12477438 0.501 rs17759607 chr2:99737005 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.44 0.64 9.76e-32 Chronic sinus infection; CESC cis rs6942756 0.531 rs2896415 chr7:128904523 G/A cg02491457 chr7:128862824 NA 0.46 6.6 0.38 2.2e-10 White matter hyperintensity burden; CESC cis rs9818758 0.545 rs11717978 chr3:48969036 T/A cg00383909 chr3:49044727 WDR6 0.92 6.76 0.38 8.71e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs1067327 1 rs1067327 chr2:44628529 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 6.51 0.37 3.65e-10 Anxiety disorder (factor score); CESC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg08736216 chr1:53307985 ZYG11A 0.41 6.85 0.39 5.29e-11 Monocyte count; CESC cis rs7219021 0.926 rs10468570 chr17:46862085 G/A cg16584676 chr17:46985605 UBE2Z -0.56 -6.44 -0.37 5.45e-10 Schizophrenia or bipolar disorder; CESC cis rs4481887 0.790 rs6587440 chr1:248415662 A/G cg00666640 chr1:248458726 OR2T12 0.33 5.72 0.33 2.87e-8 Common traits (Other); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07089834 chr17:79239572 SLC38A10 0.5 6.81 0.39 6.46e-11 Fibrinogen levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10450178 chr12:89920041 WDR51B -0.49 -6.69 -0.38 1.35e-10 Gut microbiota (bacterial taxa); CESC cis rs17253792 0.545 rs12879705 chr14:56017684 C/G cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs4076764 0.881 rs10917758 chr1:163430652 G/A cg24596788 chr1:163392923 NA -0.41 -5.79 -0.34 1.96e-8 Motion sickness; CESC cis rs367615 0.879 rs4351197 chr5:108866667 A/G cg17395555 chr5:108820864 NA 0.57 8.42 0.46 2.39e-15 Colorectal cancer (SNP x SNP interaction); CESC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg25036284 chr2:26402008 FAM59B -0.83 -9.16 -0.49 1.46e-17 Gut microbiome composition (summer); CESC cis rs2795502 1.000 rs3121323 chr10:43377166 A/G cg20628663 chr10:43360327 NA -0.56 -6.82 -0.39 6.19e-11 Blood protein levels; CESC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs7259376 0.936 rs1865075 chr19:22554854 T/C cg02657401 chr19:22469223 NA -0.25 -5.05 -0.3 8.34e-7 Menopause (age at onset); CESC cis rs1215050 0.791 rs165237 chr4:98712029 T/C cg05340658 chr4:99064831 C4orf37 0.5 6.37 0.36 8.34e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs6088590 0.687 rs73106933 chr20:33287425 T/C cg08999081 chr20:33150536 PIGU 0.64 10.41 0.54 1.64e-21 Coronary artery disease; CESC cis rs8078723 0.714 rs9915252 chr17:38145088 C/G cg17467752 chr17:38218738 THRA -0.57 -8.48 -0.46 1.57e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs1707322 1.000 rs785465 chr1:46522577 G/T cg06784218 chr1:46089804 CCDC17 0.34 5.85 0.34 1.41e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.64 -0.51 4.86e-19 Alzheimer's disease; CESC cis rs10751667 0.666 rs4074233 chr11:977685 G/A cg06064525 chr11:970664 AP2A2 -0.47 -9.12 -0.49 1.9e-17 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17887793 chr1:161494110 HSPA6 0.53 6.36 0.36 8.84e-10 Gut microbiome composition (summer); CESC cis rs12413816 0.784 rs35537139 chr10:13768894 G/A cg16485048 chr10:13749193 FRMD4A 0.48 5.9 0.34 1.14e-8 Red cell distribution width; CESC cis rs863345 0.967 rs2157689 chr1:158459264 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.01 -0.35 6.27e-9 Pneumococcal bacteremia; CESC cis rs1153858 0.621 rs12913645 chr15:45555066 G/A cg21132104 chr15:45694354 SPATA5L1 -0.74 -8.64 -0.47 5.35e-16 Homoarginine levels; CESC cis rs4523957 0.820 rs9908972 chr17:2103810 A/C cg16513277 chr17:2031491 SMG6 -0.67 -9.25 -0.49 7.79e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs175714 0.845 rs175706 chr14:75976200 G/A cg01624173 chr14:75981868 NA 0.57 8.11 0.45 1.87e-14 Lymphocyte counts; CESC cis rs2294693 0.891 rs1072119 chr6:40993072 G/A cg14418226 chr6:40996092 UNC5CL 0.52 6.3 0.36 1.2e-9 Gastric cancer;Non-cardia gastric cancer; CESC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg24829409 chr8:58192753 C8orf71 -0.67 -7.3 -0.41 3.45e-12 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg11663144 chr21:46675770 NA -0.51 -7.05 -0.4 1.53e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7927592 0.913 rs11228292 chr11:68379772 C/T cg20283391 chr11:68216788 NA -0.61 -7.39 -0.41 1.87e-12 Total body bone mineral density; CESC cis rs11792861 0.591 rs2282206 chr9:111746267 A/G cg05043794 chr9:111880884 C9orf5 -0.32 -5.68 -0.33 3.56e-8 Menarche (age at onset); CESC cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg20476274 chr7:133979776 SLC35B4 0.67 9.79 0.52 1.65e-19 Mean platelet volume; CESC cis rs11690935 1.000 rs35549875 chr2:172532392 A/G cg13550731 chr2:172543902 DYNC1I2 0.93 13.56 0.64 3.73e-32 Schizophrenia; CESC cis rs9596863 0.808 rs9316647 chr13:54220636 G/A ch.13.53330881F chr13:54432880 NA 0.63 5.11 0.3 6.3e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.42 5.66 0.33 3.97e-8 Lymphocyte counts; CESC cis rs7520050 0.778 rs12404197 chr1:46232420 G/A cg06784218 chr1:46089804 CCDC17 -0.31 -5.59 -0.32 5.66e-8 Red blood cell count;Reticulocyte count; CESC cis rs6500395 0.889 rs2080507 chr16:48688634 T/A cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg05564831 chr3:52568323 NT5DC2 0.41 5.95 0.34 8.52e-9 Bipolar disorder; CESC cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg23711669 chr6:146136114 FBXO30 -0.99 -15.23 -0.68 4.75e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg00484396 chr16:3507460 NAT15 -0.57 -6.35 -0.36 9.52e-10 Tuberculosis; CESC cis rs2603127 0.768 rs959106 chr3:108479517 A/G cg03329597 chr3:108125523 MYH15 0.6 5.35 0.31 1.91e-7 Hemostatic factors and hematological phenotypes; CESC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg07507251 chr3:52567010 NT5DC2 0.44 7.65 0.43 3.83e-13 Bipolar disorder; CESC trans rs7618501 1.000 rs57648519 chr3:49813169 C/A cg21659725 chr3:3221576 CRBN 0.83 13.52 0.64 4.88e-32 Intelligence (multi-trait analysis); CESC cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg11502198 chr6:26597334 ABT1 0.52 5.31 0.31 2.35e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7116495 0.609 rs2845860 chr11:71716661 C/T cg26138937 chr11:71823887 C11orf51 -1.22 -8.0 -0.44 3.97e-14 Severe influenza A (H1N1) infection; CESC cis rs36051895 0.623 rs7027871 chr9:5236822 C/G cg02405213 chr9:5042618 JAK2 0.61 7.29 0.41 3.56e-12 Pediatric autoimmune diseases; CESC trans rs7326068 0.576 rs34880311 chr13:21329255 A/T cg00192819 chr18:76486611 NA 0.43 6.01 0.35 6.11e-9 Schizophrenia, bipolar disorder and depression (combined); CESC cis rs863345 0.584 rs10908677 chr1:158506186 C/T cg12129480 chr1:158549410 OR10X1 0.27 5.56 0.32 6.55e-8 Pneumococcal bacteremia; CESC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg23248424 chr5:179741104 GFPT2 0.56 7.81 0.43 1.38e-13 Height; CESC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg19077165 chr18:44547161 KATNAL2 -0.61 -9.35 -0.5 3.87e-18 Personality dimensions; CESC cis rs6754311 0.731 rs2236783 chr2:136594158 G/A cg15123519 chr2:136567270 LCT 0.34 5.55 0.32 6.92e-8 Mosquito bite size; CESC cis rs2652822 0.525 rs35594365 chr15:63520154 T/C cg02713581 chr15:63449717 RPS27L 0.48 6.22 0.36 1.95e-9 Metabolic traits; CESC cis rs654950 1.000 rs646228 chr1:41986066 A/C cg06885757 chr1:42089581 HIVEP3 0.53 8.21 0.45 1.01e-14 Airway imaging phenotypes; CESC cis rs453301 0.658 rs12114954 chr8:8904862 T/G cg15556689 chr8:8085844 FLJ10661 -0.51 -6.35 -0.36 9.38e-10 Joint mobility (Beighton score); CESC cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg26597838 chr10:835615 NA 0.74 6.87 0.39 4.52e-11 Eosinophil percentage of granulocytes; CESC cis rs8114671 0.836 rs745849 chr20:33572178 G/A cg06115741 chr20:33292138 TP53INP2 -0.44 -5.23 -0.31 3.46e-7 Height; CESC cis rs13256369 0.802 rs11995449 chr8:8559898 G/A cg17143192 chr8:8559678 CLDN23 0.77 8.61 0.47 6.8e-16 Obesity-related traits; CESC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg22800045 chr5:56110881 MAP3K1 0.73 9.21 0.49 1e-17 Initial pursuit acceleration; CESC cis rs2050392 0.928 rs2250077 chr10:30702929 A/G cg25182066 chr10:30743637 MAP3K8 -0.39 -5.28 -0.31 2.71e-7 Inflammatory bowel disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07423838 chr7:73062350 NA -0.46 -6.63 -0.38 1.9e-10 Gambling; CESC cis rs4629180 0.586 rs1509494 chr2:102134862 G/T cg04415270 chr2:102091202 RFX8 -0.3 -5.11 -0.3 6.1e-7 Chronic rhinosinusitis with nasal polyps; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21662494 chr21:37502552 NA 0.64 6.85 0.39 5.12e-11 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs10133962 chr14:56066088 G/A cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC cis rs733592 0.524 rs10875727 chr12:48426143 T/C cg04545296 chr12:48745243 ZNF641 -0.29 -5.46 -0.32 1.07e-7 Plateletcrit; CESC cis rs7777484 0.571 rs2527686 chr7:2834413 G/A cg19717773 chr7:2847554 GNA12 -0.68 -11.82 -0.59 3.61e-26 Height; CESC cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg02079420 chr8:82753780 SNX16 -0.54 -8.28 -0.45 6.31e-15 Diastolic blood pressure; CESC cis rs1461503 0.809 rs7121955 chr11:122845478 A/T cg27398637 chr11:122830231 C11orf63 -0.55 -8.03 -0.44 3.2e-14 Menarche (age at onset); CESC cis rs4423214 1.000 rs12807718 chr11:71171170 T/C cg05163923 chr11:71159392 DHCR7 0.83 11.29 0.57 2.17e-24 Vitamin D levels; CESC cis rs2075371 0.897 rs12667905 chr7:134000812 A/C cg20476274 chr7:133979776 SLC35B4 0.61 8.7 0.47 3.49e-16 Mean platelet volume; CESC cis rs10870270 1.000 rs7199 chr10:133769848 C/G cg26149184 chr10:133730230 NA 0.38 5.14 0.3 5.22e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7680126 0.633 rs4697743 chr4:10294833 A/G cg00071950 chr4:10020882 SLC2A9 -0.51 -5.73 -0.33 2.66e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg22538323 chr7:27702700 HIBADH -0.44 -6.11 -0.35 3.63e-9 Vertical cup-disc ratio; CESC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg23281280 chr6:28129359 ZNF389 0.5 6.98 0.39 2.39e-11 Depression; CESC cis rs7527798 0.592 rs6671969 chr1:207839667 C/T cg21110645 chr1:207815933 NA -0.3 -5.28 -0.31 2.75e-7 Erythrocyte sedimentation rate; CESC cis rs9309473 0.950 rs6546859 chr2:73842055 C/A cg20560298 chr2:73613845 ALMS1 -0.43 -5.74 -0.33 2.61e-8 Metabolite levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02126464 chr7:128695174 LOC286016;TNPO3 0.46 6.25 0.36 1.61e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6088580 0.524 rs1853056 chr20:33262058 C/T cg08999081 chr20:33150536 PIGU -0.43 -6.02 -0.35 5.65e-9 Glomerular filtration rate (creatinine); CESC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg18402987 chr7:1209562 NA 0.76 7.61 0.42 4.74e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.659 rs11090049 chr22:41915329 C/T cg06634786 chr22:41940651 POLR3H -0.7 -7.1 -0.4 1.15e-11 Vitiligo; CESC cis rs42648 0.837 rs4728879 chr7:89924237 T/G cg23697855 chr7:89950296 NA 0.28 5.25 0.31 3.08e-7 Homocysteine levels; CESC cis rs3857067 0.806 rs6532472 chr4:95110113 A/G cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC cis rs2120019 0.938 rs2120020 chr15:75316845 T/C cg09165964 chr15:75287851 SCAMP5 -0.8 -9.87 -0.52 9.2e-20 Blood trace element (Zn levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13284070 chr3:128483832 RAB7A -0.65 -6.91 -0.39 3.5e-11 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09965679 chr14:75179859 FCF1;KIAA0317 -0.43 -6.0 -0.35 6.37e-9 Gut microbiota (bacterial taxa); CESC trans rs7980799 0.654 rs10844618 chr12:33625010 A/G cg26384229 chr12:38710491 ALG10B -0.55 -7.81 -0.43 1.32e-13 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs6500602 0.928 rs3747581 chr16:4462619 A/G cg08645402 chr16:4508243 NA 0.47 7.27 0.41 4e-12 Schizophrenia; CESC cis rs7927592 0.913 rs3740629 chr11:68343593 C/T cg20283391 chr11:68216788 NA -0.61 -7.29 -0.41 3.48e-12 Total body bone mineral density; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg07483432 chr12:72079704 TMEM19 -0.45 -7.12 -0.4 9.87e-12 Vertical cup-disc ratio; CESC cis rs864537 0.584 rs7523907 chr1:167427247 A/G cg22356347 chr1:167427500 CD247 -0.29 -5.96 -0.34 7.98e-9 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03625951 chr6:149867442 PPIL4 -0.5 -7.29 -0.41 3.5e-12 Gambling; CESC cis rs2295499 0.615 rs57978437 chr4:2711162 C/T cg08330972 chr4:2403930 ZFYVE28 -0.33 -5.41 -0.32 1.41e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs9457247 0.566 rs10946207 chr6:167456036 C/T cg23791538 chr6:167370224 RNASET2 -0.54 -6.99 -0.39 2.22e-11 Crohn's disease; CESC cis rs4253772 0.550 rs739164 chr22:46684558 C/T cg14686297 chr22:46650375 NA 0.4 5.19 0.3 4.13e-7 LDL cholesterol;Cholesterol, total; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21751231 chr11:64490736 NRXN2 -0.37 -6.94 -0.39 2.98e-11 Gambling; CESC cis rs12144309 0.608 rs1217408 chr1:114396280 T/C cg13572289 chr1:114447746 DCLRE1B;AP4B1 0.44 5.15 0.3 5.07e-7 Coronary artery disease; CESC cis rs78707713 0.560 rs35060419 chr10:71229539 A/G cg12610070 chr10:71211762 TSPAN15 -0.32 -6.75 -0.38 9.22e-11 Venous thromboembolism; CESC cis rs59724122 0.542 rs28633173 chr8:27446980 A/G cg01579299 chr8:27450062 NA 0.45 5.46 0.32 1.11e-7 Bipolar disorder lithium response (categorical) or schizophrenia; CESC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg16405210 chr4:1374714 KIAA1530 -0.44 -5.46 -0.32 1.11e-7 Obesity-related traits; CESC cis rs8070740 0.838 rs1050390 chr17:5336058 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.57 6.74 0.38 9.9e-11 Menopause (age at onset); CESC cis rs6088580 0.634 rs6087579 chr20:32985155 A/G cg06115741 chr20:33292138 TP53INP2 -0.46 -5.93 -0.34 9.62e-9 Glomerular filtration rate (creatinine); CESC cis rs7107174 1.000 rs2511168 chr11:77965081 T/G cg02023728 chr11:77925099 USP35 0.44 6.23 0.36 1.84e-9 Testicular germ cell tumor; CESC cis rs2997447 0.739 rs72884784 chr1:26432246 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs6754311 0.731 rs1470457 chr2:136581848 A/G cg15123519 chr2:136567270 LCT -0.33 -5.85 -0.34 1.46e-8 Mosquito bite size; CESC cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg05340658 chr4:99064831 C4orf37 0.78 11.94 0.59 1.39e-26 Colonoscopy-negative controls vs population controls; CESC cis rs6580649 0.941 rs4760618 chr12:48434767 G/A cg05342945 chr12:48394962 COL2A1 0.54 6.11 0.35 3.53e-9 Lung cancer; CESC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg19163074 chr7:65112434 INTS4L2 0.4 5.07 0.3 7.58e-7 Aortic root size; CESC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg23283495 chr1:209979779 IRF6 0.52 6.16 0.35 2.65e-9 Cleft lip with or without cleft palate; CESC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg25036284 chr2:26402008 FAM59B 0.84 9.53 0.51 1.04e-18 Gut microbiome composition (summer); CESC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg02269571 chr22:50332266 NA -0.55 -6.8 -0.39 7.11e-11 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25107717 chr1:94312368 MIR760 0.66 7.83 0.43 1.14e-13 Gut microbiome composition (summer); CESC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg18337363 chr3:52569053 NT5DC2 0.3 5.5 0.32 8.87e-8 Electroencephalogram traits; CESC cis rs1964356 0.967 rs17701675 chr8:8850633 A/G cg06636001 chr8:8085503 FLJ10661 -0.42 -5.64 -0.33 4.32e-8 Mean corpuscular volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26770187 chr3:14693171 C3orf19 0.48 6.34 0.36 9.72e-10 Gut microbiota (bacterial taxa); CESC cis rs2932538 0.883 rs7549547 chr1:113086717 A/T cg22162597 chr1:113214053 CAPZA1 0.56 7.0 0.39 2.15e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg18882091 chr7:99058544 ATP5J2 -0.43 -6.28 -0.36 1.36e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs11971779 0.878 rs4732378 chr7:139120395 C/T cg07862535 chr7:139043722 LUC7L2 0.57 5.67 0.33 3.64e-8 Diisocyanate-induced asthma; CESC cis rs796364 0.756 rs2949006 chr2:200715388 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.9 8.82 0.48 1.57e-16 Schizophrenia; CESC cis rs1506636 0.924 rs4370458 chr7:123260968 G/A cg03229431 chr7:123269106 ASB15 -0.52 -6.8 -0.39 7.05e-11 Plateletcrit;Platelet count; CESC trans rs1814175 0.588 rs10466497 chr11:49864381 A/T cg03929089 chr4:120376271 NA -0.9 -14.58 -0.67 9.13e-36 Height; CESC cis rs9902453 0.726 rs4795523 chr17:28176314 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.73 9.67 0.51 3.74e-19 Coffee consumption (cups per day); CESC cis rs7523050 0.643 rs7551142 chr1:109399710 G/T cg08274380 chr1:109419600 GPSM2 0.83 5.58 0.32 5.89e-8 Fat distribution (HIV); CESC cis rs9470366 0.527 rs4711456 chr6:36632482 C/T cg08179530 chr6:36648295 CDKN1A -0.63 -9.28 -0.5 6.12e-18 QRS duration; CESC cis rs78456975 0.506 rs13402886 chr2:1575348 G/A cg26248373 chr2:1572462 NA -0.57 -6.58 -0.37 2.55e-10 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg01475377 chr6:109611718 NA -0.49 -8.21 -0.45 9.56e-15 Reticulocyte fraction of red cells; CESC cis rs1707322 0.752 rs4660313 chr1:46110841 A/G cg06784218 chr1:46089804 CCDC17 -0.4 -6.94 -0.39 3e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3812565 0.506 rs4259518 chr9:139322503 T/C cg14169450 chr9:139327907 INPP5E 0.54 8.08 0.44 2.26e-14 Granulocyte percentage of myeloid white cells; CESC cis rs7267979 0.903 rs6050482 chr20:25226327 C/T cg08601574 chr20:25228251 PYGB 0.39 5.83 0.34 1.62e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg21918786 chr6:109611834 NA -0.41 -6.07 -0.35 4.49e-9 Reticulocyte fraction of red cells; CESC cis rs1670533 1.000 rs6821725 chr4:1060360 C/G cg27284194 chr4:1044797 NA 0.47 6.07 0.35 4.4e-9 Recombination rate (females); CESC cis rs7727544 0.735 rs2631370 chr5:131703776 T/C cg24060327 chr5:131705240 SLC22A5 0.67 8.84 0.48 1.41e-16 Blood metabolite levels; CESC cis rs67478160 0.634 rs7141928 chr14:104219949 C/T cg01849466 chr14:104193079 ZFYVE21 -0.52 -7.62 -0.42 4.49e-13 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16319310 chr10:52390957 NA -0.7 -8.38 -0.46 3.12e-15 Gut microbiome composition (summer); CESC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg23985595 chr17:80112537 CCDC57 0.41 6.42 0.37 6.41e-10 Life satisfaction; CESC cis rs9815354 0.812 rs73077361 chr3:41850146 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs897984 0.683 rs729482 chr16:31016970 T/C cg02466173 chr16:30829666 NA -0.44 -7.11 -0.4 1.1e-11 Dementia with Lewy bodies; CESC cis rs9297145 1.000 rs9297145 chr7:98759117 A/C cg05967295 chr7:98741636 SMURF1 0.95 12.55 0.61 1.11e-28 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs10979 0.597 rs9403514 chr6:143907790 T/C cg25407410 chr6:143891975 LOC285740 -0.49 -6.31 -0.36 1.16e-9 Hypospadias; CESC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg14159672 chr1:205819179 PM20D1 0.79 12.7 0.62 3.4e-29 Menarche (age at onset); CESC cis rs9457247 0.534 rs933243 chr6:167403873 A/C cg23791538 chr6:167370224 RNASET2 -0.66 -9.43 -0.5 2.09e-18 Crohn's disease; CESC cis rs75477785 0.590 rs12061641 chr1:210255104 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.95 6.41 0.37 6.82e-10 Cleft lip with or without cleft palate; CESC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7818345 0.845 rs11785649 chr8:19268233 G/A cg11303988 chr8:19266685 CSGALNACT1 0.38 6.62 0.38 1.95e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg02461776 chr11:598696 PHRF1 0.5 5.85 0.34 1.46e-8 Systemic lupus erythematosus; CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg06877462 chr1:205807181 PM20D1 -0.34 -5.4 -0.31 1.47e-7 Monocyte percentage of white cells; CESC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg25072359 chr17:41440525 NA 0.45 5.28 0.31 2.71e-7 Menopause (age at onset); CESC cis rs1707322 1.000 rs7538978 chr1:46505054 C/T cg05343316 chr1:45956843 TESK2 -0.44 -5.41 -0.32 1.38e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7000551 0.725 rs2449349 chr8:22383284 A/G cg12081754 chr8:22256438 SLC39A14 0.39 5.22 0.31 3.6e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs6840258 1.000 rs75550773 chr4:87955423 G/T cg08197287 chr4:87952173 AFF1 -0.38 -5.27 -0.31 2.85e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg04944784 chr2:26401820 FAM59B 0.63 7.39 0.41 1.94e-12 Gut microbiome composition (summer); CESC cis rs6973256 0.583 rs6955530 chr7:133339511 T/C cg10665199 chr7:133106180 EXOC4 0.46 6.21 0.36 2e-9 Intelligence (multi-trait analysis); CESC cis rs2243480 1.000 rs12698509 chr7:65418876 C/T cg18252515 chr7:66147081 NA -1.03 -9.89 -0.52 7.88e-20 Diabetic kidney disease; CESC cis rs9341835 0.511 rs1744146 chr6:64221869 A/C cg03326410 chr6:64151739 NA 0.32 5.15 0.3 5.1e-7 Schizophrenia; CESC cis rs6582630 0.539 rs35114325 chr12:38320886 G/T cg26384229 chr12:38710491 ALG10B -0.46 -5.96 -0.34 8.17e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs2929278 0.617 rs693919 chr15:44102328 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.47 -7.2 -0.4 6.27e-12 Schizophrenia; CESC cis rs7772486 0.658 rs6570706 chr6:145962922 T/C cg23711669 chr6:146136114 FBXO30 0.86 12.69 0.61 3.91e-29 Lobe attachment (rater-scored or self-reported); CESC trans rs1814175 0.645 rs10128563 chr11:50023681 T/C cg03929089 chr4:120376271 NA -0.91 -14.8 -0.67 1.58e-36 Height; CESC cis rs7927592 0.913 rs10896329 chr11:68250029 A/G cg20283391 chr11:68216788 NA -0.64 -7.81 -0.43 1.36e-13 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02306946 chr12:105630036 APPL2 0.55 6.79 0.38 7.28e-11 Gut microbiome composition (summer); CESC cis rs6460942 1.000 rs17191008 chr7:12417690 T/G cg10578991 chr7:12443926 VWDE -0.53 -5.69 -0.33 3.35e-8 Coronary artery disease; CESC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg11764359 chr7:65958608 NA -0.78 -11.43 -0.57 7.35e-25 Aortic root size; CESC cis rs7617773 0.514 rs11130166 chr3:48388056 A/G cg11946769 chr3:48343235 NME6 0.65 8.35 0.46 3.86e-15 Coronary artery disease; CESC cis rs10129255 0.957 rs10141009 chr14:107184934 A/G cg23076370 chr14:107095027 NA -0.48 -6.29 -0.36 1.32e-9 Kawasaki disease; CESC cis rs7829975 0.684 rs488904 chr8:8587571 T/G cg06636001 chr8:8085503 FLJ10661 -0.42 -5.17 -0.3 4.64e-7 Mood instability; CESC cis rs7584330 0.666 rs72620818 chr2:238354652 G/A cg14458575 chr2:238380390 NA 0.85 10.76 0.55 1.22e-22 Prostate cancer; CESC cis rs708547 0.871 rs2687238 chr4:57880474 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.52 -5.54 -0.32 7.27e-8 Response to bleomycin (chromatid breaks); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00436610 chr16:89284637 ZNF778 -0.62 -7.06 -0.4 1.43e-11 Gut microbiome composition (summer); CESC cis rs7100689 0.784 rs7895042 chr10:82095276 G/A cg00277334 chr10:82204260 NA -0.59 -7.47 -0.42 1.14e-12 Post bronchodilator FEV1; CESC cis rs9486715 0.659 rs9399930 chr6:96854444 G/T cg18709589 chr6:96969512 KIAA0776 0.49 6.76 0.38 9e-11 Headache; CESC cis rs17125944 0.505 rs77690283 chr14:53233320 C/G cg00686598 chr14:53173677 PSMC6 1.34 11.5 0.58 4.42e-25 Alzheimer's disease (late onset); CESC cis rs6963495 0.818 rs73190186 chr7:105164368 G/C cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs2425143 1.000 rs7267759 chr20:34257284 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -7.53 -0.42 8.04e-13 Blood protein levels; CESC cis rs6460942 1.000 rs62448562 chr7:12398785 T/C cg10578991 chr7:12443926 VWDE -0.58 -6.08 -0.35 4.26e-9 Coronary artery disease; CESC cis rs12822507 0.732 rs873218 chr12:12765603 G/A cg11838227 chr12:12764436 CREBL2 0.43 5.63 0.33 4.48e-8 Systemic lupus erythematosus; CESC cis rs8060686 0.858 rs6499143 chr16:67874264 T/C cg26727032 chr16:67993705 SLC12A4 -0.68 -9.79 -0.52 1.61e-19 HDL cholesterol;Metabolic syndrome; CESC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg11764359 chr7:65958608 NA 0.97 15.73 0.69 7.9e-40 Aortic root size; CESC cis rs7605827 0.729 rs35131126 chr2:15537730 A/G cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs1538970 0.924 rs11211118 chr1:45930270 A/C cg03146154 chr1:46216737 IPP 0.45 5.24 0.31 3.31e-7 Platelet count; CESC cis rs7617773 0.963 rs12495221 chr3:48179178 C/T cg11946769 chr3:48343235 NME6 -0.58 -7.73 -0.43 2.26e-13 Coronary artery disease; CESC cis rs4664293 0.967 rs12611922 chr2:160462749 T/G cg08347373 chr2:160653686 CD302 -0.33 -5.24 -0.31 3.33e-7 Monocyte percentage of white cells; CESC cis rs7208859 0.573 rs55661352 chr17:29045628 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.37 0.36 8.33e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9611519 0.808 rs5751074 chr22:41665722 G/A cg03806693 chr22:41940476 POLR3H -0.58 -6.72 -0.38 1.08e-10 Neuroticism; CESC cis rs3820068 0.705 rs41270255 chr1:15892980 G/A cg17385448 chr1:15911702 AGMAT 0.37 5.81 0.34 1.8e-8 Systolic blood pressure; CESC cis rs3738443 0.520 rs1771932 chr1:247382049 A/G cg07706540 chr1:247373924 NA -0.47 -5.67 -0.33 3.63e-8 Alcohol dependence; CESC cis rs3806843 0.735 rs801180 chr5:140092903 G/T cg16179182 chr5:140090404 VTRNA1-1 0.42 5.43 0.32 1.27e-7 Depressive symptoms (multi-trait analysis); CESC cis rs8028182 0.636 rs8036758 chr15:75817562 G/A cg20655648 chr15:75932815 IMP3 0.47 5.81 0.34 1.75e-8 Sudden cardiac arrest; CESC cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg05347473 chr6:146136440 FBXO30 -0.57 -7.36 -0.41 2.27e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg18876405 chr7:65276391 NA -0.59 -7.9 -0.44 7.25e-14 Aortic root size; CESC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg06456125 chr7:65229604 NA -0.39 -5.37 -0.31 1.75e-7 Aortic root size; CESC trans rs6587515 0.901 rs3738483 chr1:150801466 T/C cg23436960 chr14:77239540 VASH1 0.45 5.99 0.35 6.67e-9 Pericardial adipose tissue adjusted for height and weight; CESC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -6.82 -0.39 5.97e-11 Bipolar disorder; CESC cis rs9905704 0.671 rs2531737 chr17:56554357 A/G cg12560992 chr17:57184187 TRIM37 -0.62 -5.93 -0.34 9.6e-9 Testicular germ cell tumor; CESC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg18099408 chr3:52552593 STAB1 -0.31 -5.16 -0.3 4.75e-7 Bipolar disorder; CESC cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.06 0.49 2.94e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.09 0.56 9.7e-24 Alzheimer's disease; CESC cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.1 0.49 2.28e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2637266 0.653 rs2583068 chr10:78553731 T/C cg18941641 chr10:78392320 NA 0.4 7.57 0.42 6.04e-13 Pulmonary function; CESC cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg11166453 chr1:247681781 NA 0.44 5.77 0.33 2.24e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs9287719 0.901 rs4555317 chr2:10744247 A/G cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg04025307 chr7:1156635 C7orf50 0.44 5.33 0.31 2.16e-7 Bronchopulmonary dysplasia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20919306 chr17:11924526 MAP2K4 -0.48 -6.46 -0.37 4.94e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00974149 chr17:56296512 MKS1 0.55 6.32 0.36 1.09e-9 Gut microbiome composition (summer); CESC cis rs11098499 0.580 rs12509234 chr4:120319434 T/C cg24375607 chr4:120327624 NA 0.48 5.82 0.34 1.66e-8 Corneal astigmatism; CESC trans rs7577696 0.962 rs13022197 chr2:32343167 A/T cg00459447 chr7:108210006 THAP5;DNAJB9 0.38 6.06 0.35 4.68e-9 Inflammatory biomarkers; CESC cis rs2204008 0.617 rs11831608 chr12:38210687 C/T cg26384229 chr12:38710491 ALG10B -0.46 -6.27 -0.36 1.46e-9 Bladder cancer; CESC cis rs57083693 0.518 rs10860711 chr12:101723568 T/G cg22051763 chr12:101673672 UTP20 -0.45 -5.59 -0.32 5.71e-8 Alcohol dependence (age at onset); CESC cis rs8060686 0.641 rs8058690 chr16:68136622 T/G cg26727032 chr16:67993705 SLC12A4 -0.52 -6.33 -0.36 1.05e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05874913 chr2:160569340 MARCH7 -0.55 -7.36 -0.41 2.39e-12 Fibrinogen levels; CESC cis rs72781680 1.000 rs55982282 chr2:24188128 G/A cg08917208 chr2:24149416 ATAD2B 1.03 9.37 0.5 3.32e-18 Lymphocyte counts; CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg23034840 chr1:205782522 SLC41A1 0.69 8.35 0.46 3.84e-15 Menarche (age at onset); CESC cis rs1670533 1.000 rs11247972 chr4:1060550 A/G cg27284194 chr4:1044797 NA 0.47 6.07 0.35 4.4e-9 Recombination rate (females); CESC cis rs7577696 0.568 rs7562653 chr2:32478629 T/C cg02381751 chr2:32503542 YIPF4 0.46 5.51 0.32 8.49e-8 Inflammatory biomarkers; CESC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.52 0.37 3.64e-10 Depression; CESC cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg17143192 chr8:8559678 CLDN23 0.78 8.81 0.48 1.63e-16 Obesity-related traits; CESC cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs7659604 0.502 rs28435300 chr4:122709412 T/C cg19671926 chr4:122722719 EXOSC9 0.67 8.89 0.48 9.9900000000000006e-17 Type 2 diabetes; CESC cis rs763121 0.853 rs2413547 chr22:39107338 A/G cg14440974 chr22:39074834 NA -0.42 -5.73 -0.33 2.69e-8 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07545535 chr7:76256818 POMZP3;LOC100133091 0.6 7.27 0.41 4.09e-12 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.45 7.14 0.4 8.76e-12 Personality dimensions; CESC cis rs4888262 0.508 rs4544266 chr16:74660993 C/A cg01733217 chr16:74700730 RFWD3 0.85 10.7 0.55 1.88e-22 Testicular germ cell tumor; CESC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg24675658 chr1:53192096 ZYG11B -0.61 -7.88 -0.44 8.59e-14 Monocyte count; CESC cis rs11679564 0.714 rs4670638 chr2:37164911 C/G cg14987922 chr2:37194071 STRN 0.42 5.33 0.31 2.11e-7 Immature fraction of reticulocytes; CESC cis rs5758511 0.680 rs34107327 chr22:42648353 T/G cg00645731 chr22:42541494 CYP2D7P1 0.57 8.61 0.47 6.72e-16 Birth weight; CESC cis rs713587 0.520 rs519111 chr2:25333735 T/C cg01884057 chr2:25150051 NA -0.3 -5.21 -0.3 3.89e-7 Body mass index in non-asthmatics; CESC cis rs80282103 0.764 rs7093915 chr10:1107341 A/G cg08668510 chr10:1095578 IDI1 -0.66 -5.58 -0.32 6.07e-8 Glomerular filtration rate (creatinine); CESC cis rs3820928 1.000 rs10193316 chr2:227777650 A/G cg11843606 chr2:227700838 RHBDD1 -0.44 -5.86 -0.34 1.4e-8 Pulmonary function; CESC cis rs870825 0.616 rs72703531 chr4:185611092 C/T cg04058563 chr4:185651563 MLF1IP 0.64 6.47 0.37 4.64e-10 Blood protein levels; CESC cis rs6580649 0.941 rs72644842 chr12:48448274 A/G cg05342945 chr12:48394962 COL2A1 0.5 5.85 0.34 1.47e-8 Lung cancer; CESC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.56 -7.1 -0.4 1.18e-11 Tonsillectomy; CESC cis rs3087591 1.000 rs7220483 chr17:29577248 G/A cg24425628 chr17:29625626 OMG;NF1 -0.42 -5.08 -0.3 7.22e-7 Hip circumference; CESC cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg26061582 chr7:22766209 IL6 0.48 5.24 0.31 3.35e-7 Lung cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23466916 chr2:192543328 OBFC2A -0.44 -6.09 -0.35 3.89e-9 Gut microbiota (bacterial taxa); CESC cis rs72627123 0.656 rs6574169 chr14:74637178 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 -0.75 -5.25 -0.31 3.11e-7 Morning vs. evening chronotype; CESC trans rs561341 1.000 rs576985 chr17:30323323 C/T cg27661571 chr11:113659931 NA -0.82 -7.63 -0.42 4.18e-13 Hip circumference adjusted for BMI; CESC cis rs684232 0.583 rs4968094 chr17:507120 A/T cg15660573 chr17:549704 VPS53 -0.81 -11.77 -0.59 5.08e-26 Prostate cancer; CESC cis rs12900413 0.687 rs6496599 chr15:90314582 C/T cg24249390 chr15:90295951 MESP1 -0.41 -5.73 -0.33 2.78e-8 Coronary artery aneurysm in Kawasaki disease; CESC trans rs4942242 0.663 rs9525817 chr13:44225189 C/T cg19169023 chr15:41853346 TYRO3 0.65 8.17 0.45 1.29e-14 Response to tocilizumab in rheumatoid arthritis; CESC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg14393609 chr7:65229607 NA 0.48 6.47 0.37 4.72e-10 Aortic root size; CESC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg23708337 chr7:1209742 NA 0.55 5.38 0.31 1.67e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg24829409 chr8:58192753 C8orf71 0.61 7.03 0.4 1.74e-11 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -5.09 -0.3 6.93e-7 Developmental language disorder (linguistic errors); CESC cis rs1005277 0.540 rs11011351 chr10:38030525 A/G cg25427524 chr10:38739819 LOC399744 -0.64 -9.43 -0.5 2.21e-18 Extrinsic epigenetic age acceleration; CESC cis rs9896052 0.625 rs11656558 chr17:73440437 T/C cg25649188 chr17:73499917 CASKIN2 0.46 5.31 0.31 2.33e-7 Sight-threatening diabetic retinopathy in type 2 diabetes; CESC cis rs734999 0.505 rs10910108 chr1:2539532 A/G cg20673091 chr1:2541236 MMEL1 0.46 7.82 0.43 1.24e-13 Ulcerative colitis; CESC cis rs6772849 0.965 rs4286447 chr3:128310589 G/T cg16766828 chr3:128327626 NA -0.31 -5.06 -0.3 7.77e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg15017067 chr4:17643749 FAM184B 0.38 5.09 0.3 6.76e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs870825 0.616 rs61539306 chr4:185650276 C/T cg04058563 chr4:185651563 MLF1IP 0.62 6.83 0.39 5.67e-11 Blood protein levels; CESC cis rs752010 0.668 rs10890147 chr1:42089725 A/T cg06885757 chr1:42089581 HIVEP3 0.7 11.53 0.58 3.51e-25 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9291683 0.507 rs6827754 chr4:10018153 A/C cg11266682 chr4:10021025 SLC2A9 -0.57 -9.46 -0.5 1.79e-18 Bone mineral density; CESC cis rs3780486 0.846 rs10971420 chr9:33125000 T/C cg13443165 chr9:33130375 B4GALT1 0.44 6.38 0.37 7.66e-10 IgG glycosylation; CESC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.36 0.31 1.82e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg08736216 chr1:53307985 ZYG11A -0.41 -6.87 -0.39 4.54e-11 Monocyte count; CESC cis rs6599388 0.803 rs11248057 chr4:906131 C/G cg08222618 chr4:941054 TMEM175 -0.42 -5.47 -0.32 1.02e-7 Parkinson's disease; CESC cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.9 0.48 8.93e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs6032067 0.852 rs6032046 chr20:43823679 A/G cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.53e-7 Blood protein levels; CESC cis rs2625529 0.652 rs8028115 chr15:72339503 C/T cg16672083 chr15:72433130 SENP8 0.42 6.57 0.37 2.59e-10 Red blood cell count; CESC cis rs3733585 0.673 rs6843873 chr4:9958788 A/C cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.4e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs72634258 0.519 rs2071984 chr1:7928656 C/T cg00042356 chr1:8021962 PARK7 0.52 5.77 0.33 2.18e-8 Inflammatory bowel disease; CESC trans rs9951602 0.512 rs7234283 chr18:76640552 T/G cg02800362 chr5:177631904 HNRNPAB 0.62 8.13 0.45 1.7e-14 Obesity-related traits; CESC cis rs6964587 1.000 rs36120033 chr7:91679298 G/A cg17063962 chr7:91808500 NA 0.59 8.15 0.45 1.48e-14 Breast cancer; CESC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.17e-16 Melanoma; CESC cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg20573242 chr4:122745356 CCNA2 0.66 8.1 0.45 1.99e-14 Type 2 diabetes; CESC cis rs6748734 0.901 rs6720357 chr2:241830296 A/C cg04034577 chr2:241836375 C2orf54 -0.49 -8.33 -0.46 4.28e-15 Urinary metabolites; CESC cis rs60154123 0.730 rs608791 chr1:210464638 C/T cg22029157 chr1:209979665 IRF6 0.47 5.75 0.33 2.42e-8 Coronary artery disease; CESC cis rs7772486 0.754 rs697055 chr6:146003790 C/G cg23711669 chr6:146136114 FBXO30 1.0 14.05 0.65 7e-34 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16439118 chr18:54814548 NA 0.44 6.3 0.36 1.21e-9 Fibrinogen levels; CESC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg21784768 chr11:537496 LRRC56 -0.54 -5.08 -0.3 7.13e-7 Body mass index; CESC cis rs113835537 0.529 rs75683511 chr11:66275026 A/G cg24851651 chr11:66362959 CCS 0.49 5.86 0.34 1.34e-8 Airway imaging phenotypes; CESC cis rs12791968 0.527 rs12285862 chr11:45014326 T/G cg11846598 chr11:44996168 LOC221122 -0.55 -6.13 -0.35 3.09e-9 Inhibitory control; CESC cis rs611744 0.781 rs656406 chr8:109173843 G/A cg21045802 chr8:109455806 TTC35 0.47 5.67 0.33 3.81e-8 Dupuytren's disease; CESC cis rs10504229 0.679 rs11783557 chr8:58030644 A/G cg24829409 chr8:58192753 C8orf71 -0.44 -5.73 -0.33 2.75e-8 Developmental language disorder (linguistic errors); CESC cis rs9630089 0.622 rs7906782 chr10:98961596 C/T cg25902810 chr10:99078978 FRAT1 0.53 7.02 0.4 1.87e-11 Neutrophil percentage of white cells; CESC cis rs2439831 0.867 rs16957627 chr15:43642657 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.46 0.54 1.12e-21 Lung cancer in ever smokers; CESC trans rs9929218 1.000 rs2113200 chr16:68814948 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -8.5 -0.46 1.39e-15 Colorectal cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07307426 chr15:89089587 DET1 0.43 6.61 0.38 2.05e-10 Gambling; CESC cis rs2439831 0.867 rs2245176 chr15:43750762 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.14 0.6 2.88e-27 Lung cancer in ever smokers; CESC trans rs1814175 0.645 rs10128563 chr11:50023681 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -6.13 -0.35 3.1e-9 Height; CESC cis rs11122272 0.735 rs11122279 chr1:231519804 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.75 -0.43 2.03e-13 Hemoglobin concentration; CESC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg11494091 chr17:61959527 GH2 -0.73 -12.68 -0.61 4.17e-29 Prudent dietary pattern; CESC cis rs6541297 0.703 rs636810 chr1:230317018 C/T cg20703242 chr1:230279135 GALNT2 -0.43 -5.62 -0.33 4.84e-8 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26877198 chr19:9938416 UBL5 -0.45 -7.12 -0.4 1.01e-11 Gambling; CESC cis rs9611565 0.765 rs132908 chr22:41801795 G/A cg06481639 chr22:41940642 POLR3H 0.64 6.56 0.37 2.82e-10 Vitiligo; CESC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg17294928 chr15:75287854 SCAMP5 0.5 6.59 0.38 2.32e-10 Breast cancer; CESC cis rs9359856 0.529 rs72919922 chr6:90492997 G/A cg13799429 chr6:90582589 CASP8AP2 -0.63 -6.04 -0.35 5.17e-9 Bipolar disorder; CESC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 9.07 0.49 2.7e-17 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg11644478 chr21:40555479 PSMG1 1.05 17.79 0.74 4.12e-47 Cognitive function; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10139015 chr11:47448256 PSMC3 -0.44 -6.02 -0.35 5.68e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7635838 0.573 rs73019547 chr3:11493323 A/C cg00170343 chr3:11313890 ATG7 0.47 6.36 0.36 8.89e-10 HDL cholesterol; CESC cis rs3749237 0.595 rs4855859 chr3:49526300 C/T cg07636037 chr3:49044803 WDR6 0.61 8.81 0.48 1.66e-16 Resting heart rate; CESC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg17971929 chr21:40555470 PSMG1 0.84 12.01 0.59 7.85e-27 Cognitive function; CESC cis rs9447004 0.865 rs6924739 chr6:74445387 C/T cg23004174 chr6:74404879 CD109 0.4 6.09 0.35 3.86e-9 Blood protein levels;Calcium levels; CESC cis rs6433857 0.536 rs1971134 chr2:181351532 G/A cg23363182 chr2:181467187 NA -0.42 -5.92 -0.34 9.98e-9 Body mass index; CESC cis rs12042107 0.740 rs2166172 chr1:91208514 A/C cg13456504 chr1:91191583 NA -0.31 -5.45 -0.32 1.18e-7 Educational attainment; CESC cis rs933688 1.000 rs186717 chr5:90780467 T/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.98 11.76 0.59 5.82e-26 Smoking behavior; CESC cis rs2997447 0.761 rs17184884 chr1:26446565 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.17 0.3 4.68e-7 QRS complex (12-leadsum); CESC cis rs11098499 0.913 rs13126596 chr4:120140729 A/G cg09307838 chr4:120376055 NA 0.79 10.07 0.53 2.04e-20 Corneal astigmatism; CESC cis rs9733 0.519 rs1134067 chr1:150721175 G/T cg22823121 chr1:150693482 HORMAD1 0.47 6.58 0.37 2.52e-10 Tonsillectomy; CESC cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg05340658 chr4:99064831 C4orf37 0.76 11.26 0.57 2.63e-24 Colonoscopy-negative controls vs population controls; CESC cis rs11785400 0.793 rs2280879 chr8:143722228 T/C cg24634471 chr8:143751801 JRK 0.43 5.57 0.32 6.39e-8 Schizophrenia; CESC cis rs3859192 0.577 rs2227333 chr17:38174167 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.62 9.03 0.49 3.56e-17 White blood cell count; CESC trans rs3780486 0.846 rs10813950 chr9:33127640 A/G cg04842962 chr6:43655489 MRPS18A -0.96 -16.95 -0.72 3.81e-44 IgG glycosylation; CESC cis rs68170813 0.559 rs77150993 chr7:106817100 G/T cg02696742 chr7:106810147 HBP1 -0.53 -5.07 -0.3 7.37e-7 Coronary artery disease; CESC cis rs13168506 0.538 rs12521857 chr5:135440364 G/A cg15329133 chr5:135467951 SMAD5;SMAD5OS -0.33 -5.1 -0.3 6.57e-7 Stroke; CESC cis rs10751667 0.961 rs7480178 chr11:927108 T/C cg06064525 chr11:970664 AP2A2 -0.43 -7.7 -0.43 2.8e-13 Alzheimer's disease (late onset); CESC cis rs4481887 1.000 rs4579792 chr1:248463742 C/T cg00666640 chr1:248458726 OR2T12 -0.38 -6.19 -0.36 2.22e-9 Common traits (Other); CESC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg26314531 chr2:26401878 FAM59B -0.83 -9.26 -0.49 7.29e-18 Gut microbiome composition (summer); CESC trans rs1814175 0.645 rs11040671 chr11:49958776 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs9905704 0.846 rs302877 chr17:56764018 G/A cg12560992 chr17:57184187 TRIM37 0.62 7.88 0.44 8.72e-14 Testicular germ cell tumor; CESC cis rs2635047 0.638 rs2289133 chr18:44602249 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 6.24 0.36 1.75e-9 Educational attainment; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg06966887 chr5:443603 EXOC3;C5orf55 0.47 6.27 0.36 1.42e-9 Tetralogy of Fallot; CESC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg03351412 chr1:154909251 PMVK 0.69 9.32 0.5 4.71e-18 Prostate cancer; CESC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.72 0.33 2.89e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26963397 chr16:50059081 TMEM188 -0.49 -6.15 -0.35 2.92e-9 Asthma; CESC cis rs6662572 0.737 rs10789476 chr1:46305362 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.04 -0.3 8.65e-7 Blood protein levels; CESC cis rs11235843 0.636 rs10736793 chr11:73402576 A/C cg18195628 chr11:73498948 MRPL48 -0.48 -5.27 -0.31 2.83e-7 Hand grip strength; CESC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.7 0.33 3.27e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04096435 chr6:111195733 AMD1 -0.61 -6.63 -0.38 1.89e-10 Gut microbiome composition (summer); CESC cis rs11623869 0.711 rs2403173 chr14:103909289 T/C cg12935359 chr14:103987150 CKB -0.51 -7.49 -0.42 1.06e-12 Bone mineral density; CESC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg21782813 chr7:2030301 MAD1L1 0.49 6.96 0.39 2.75e-11 Bipolar disorder and schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23300289 chr9:132146083 NA -0.44 -6.41 -0.37 6.8e-10 Gambling; CESC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg20151795 chr6:28129481 ZNF389 0.46 5.81 0.34 1.76e-8 Depression; CESC cis rs2243480 1.000 rs778729 chr7:65824419 T/C cg13147721 chr7:65941812 NA -0.95 -8.95 -0.48 6.27e-17 Diabetic kidney disease; CESC trans rs7246760 0.867 rs57943754 chr19:9841283 G/A cg02900749 chr2:68251473 NA -0.79 -7.17 -0.4 7.34e-12 Pursuit maintenance gain; CESC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg08470875 chr2:26401718 FAM59B 0.66 7.11 0.4 1.08e-11 Gut microbiome composition (summer); CESC cis rs897080 0.515 rs786403 chr2:44710788 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.55 0.32 6.8e-8 Height; CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg01238044 chr22:24384105 GSTT1 -0.68 -9.08 -0.49 2.5e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg04025307 chr7:1156635 C7orf50 0.55 9.36 0.5 3.5e-18 Longevity;Endometriosis; CESC cis rs1538970 0.962 rs3219489 chr1:45797505 C/G cg06784218 chr1:46089804 CCDC17 0.34 5.19 0.3 4.12e-7 Platelet count; CESC cis rs17376456 0.866 rs13356088 chr5:93423479 C/T cg21475434 chr5:93447410 FAM172A 0.91 7.42 0.41 1.62e-12 Diabetic retinopathy; CESC cis rs7927771 0.524 rs10458915 chr11:47864392 T/A cg18512352 chr11:47633146 NA 0.35 5.37 0.31 1.7e-7 Subjective well-being; CESC cis rs3749237 0.595 rs7643845 chr3:49530711 A/G cg06212747 chr3:49208901 KLHDC8B 0.49 6.55 0.37 3.02e-10 Resting heart rate; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09976282 chr15:31357238 TRPM1;MIR211 -0.41 -6.12 -0.35 3.3e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06963844 chr1:11724238 FBXO6 -0.53 -6.04 -0.35 5.18e-9 Gut microbiome composition (summer); CESC cis rs9359856 0.564 rs17506403 chr6:90499059 C/G cg13799429 chr6:90582589 CASP8AP2 -0.61 -6.04 -0.35 5.32e-9 Bipolar disorder; CESC cis rs4595586 0.545 rs9669705 chr12:39374459 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg27286337 chr10:134555280 INPP5A 0.68 7.69 0.43 2.81e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4660261 0.526 rs3094954 chr1:44320919 C/T cg12908607 chr1:44402522 ARTN -0.46 -6.6 -0.38 2.26e-10 Intelligence (multi-trait analysis); CESC cis rs977987 0.843 rs4146810 chr16:75415831 A/G cg03315344 chr16:75512273 CHST6 0.4 5.78 0.33 2.14e-8 Dupuytren's disease; CESC cis rs56399783 0.901 rs79932907 chr7:2827901 C/G cg19731401 chr7:2775893 GNA12 0.67 6.04 0.35 5.19e-9 Childhood ear infection; CESC cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg06484146 chr7:12443880 VWDE -0.67 -9.2 -0.49 1.11e-17 Coronary artery disease; CESC cis rs8141529 0.753 rs5752813 chr22:29226570 T/G cg15103426 chr22:29168792 CCDC117 0.67 9.66 0.51 4.15e-19 Lymphocyte counts; CESC cis rs8044868 0.530 rs9932951 chr16:72075341 A/G cg16558253 chr16:72132732 DHX38 -0.39 -6.15 -0.35 2.86e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs9894429 1.000 rs11652797 chr17:79574124 A/G cg13777783 chr17:79615861 NA -0.34 -5.68 -0.33 3.46e-8 Eye color traits; CESC cis rs3540 0.512 rs11633872 chr15:91080512 G/A cg10434728 chr15:90938212 IQGAP1 -0.41 -7.2 -0.4 6.37e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs4268898 0.636 rs9636438 chr2:24460566 C/T cg20701182 chr2:24300061 SF3B14 -0.64 -7.07 -0.4 1.38e-11 Asthma; CESC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg27121462 chr16:89883253 FANCA -0.81 -12.1 -0.6 3.93e-27 Vitiligo; CESC cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg19729930 chr2:74357872 NA 0.86 12.78 0.62 1.82e-29 Gestational age at birth (maternal effect); CESC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg24829409 chr8:58192753 C8orf71 0.66 7.83 0.43 1.21e-13 Developmental language disorder (linguistic errors); CESC cis rs9863 0.827 rs6488913 chr12:124445569 C/G cg17562584 chr12:124393655 DNAH10 -0.3 -5.28 -0.31 2.66e-7 White blood cell count; CESC cis rs644799 0.965 rs607039 chr11:95547086 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs727505 1.000 rs722560 chr7:124488035 T/C cg23710748 chr7:124431027 NA -0.48 -7.64 -0.42 4.06e-13 Lewy body disease; CESC trans rs61931739 0.534 rs7138522 chr12:34039762 G/A cg26384229 chr12:38710491 ALG10B 0.6 8.36 0.46 3.68e-15 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27511265 chr7:150102280 LOC728743 0.58 6.06 0.35 4.75e-9 Gut microbiome composition (summer); CESC cis rs2730245 0.527 rs2730237 chr7:158706166 A/G cg24397884 chr7:158709396 WDR60 0.67 7.44 0.42 1.41e-12 Height; CESC cis rs62158211 1.000 rs4618068 chr2:114109355 C/T cg17784749 chr2:114082611 LOC440839 0.7 7.54 0.42 7.35e-13 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CESC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg22823121 chr1:150693482 HORMAD1 0.39 5.35 0.31 1.93e-7 Melanoma; CESC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg09699651 chr6:150184138 LRP11 0.4 5.1 0.3 6.4e-7 Lung cancer; CESC cis rs4653767 0.573 rs708772 chr1:226912891 A/G cg10327440 chr1:227177885 CDC42BPA -0.39 -5.15 -0.3 5.12e-7 Parkinson's disease; CESC cis rs12477438 0.520 rs720229 chr2:99704273 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.37 0.63 1.7e-31 Chronic sinus infection; CESC cis rs7301826 0.580 rs12821464 chr12:131322719 T/G cg11011512 chr12:131303247 STX2 -0.46 -5.67 -0.33 3.76e-8 Plasma plasminogen activator levels; CESC cis rs3126085 0.935 rs4845736 chr1:152175551 G/A cg03465714 chr1:152285911 FLG -0.45 -5.55 -0.32 7.03e-8 Atopic dermatitis; CESC cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7771547 0.573 rs517890 chr6:36397786 G/C cg07856975 chr6:36356162 ETV7 0.36 5.38 0.31 1.67e-7 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21149582 chr1:10532838 DFFA -0.63 -7.68 -0.43 3.02e-13 Gut microbiome composition (summer); CESC cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg15556689 chr8:8085844 FLJ10661 0.66 8.48 0.46 1.65e-15 Neuroticism; CESC cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.81 -0.39 6.51e-11 Hemoglobin concentration; CESC trans rs8073060 0.586 rs9649 chr17:34050934 C/T cg19694781 chr19:47549865 TMEM160 0.72 6.47 0.37 4.78e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs9916302 0.904 rs68178216 chr17:37526241 A/C cg07936489 chr17:37558343 FBXL20 0.78 10.74 0.55 1.4e-22 Glomerular filtration rate (creatinine); CESC cis rs734999 0.545 rs3890745 chr1:2553624 C/T cg18854424 chr1:2615690 NA -0.31 -6.09 -0.35 4.01e-9 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03639964 chr10:71415564 NA 0.39 6.11 0.35 3.62e-9 Fibrinogen levels; CESC cis rs9522267 0.535 rs7323829 chr13:112232308 C/G cg10483660 chr13:112241077 NA -0.32 -5.77 -0.33 2.19e-8 Hepatitis; CESC cis rs67478160 0.643 rs7147171 chr14:104264857 G/A cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.09 -0.4 1.2e-11 Schizophrenia; CESC cis rs854765 0.663 rs12941550 chr17:17753828 C/A cg04398451 chr17:18023971 MYO15A 0.63 9.23 0.49 8.8e-18 Total body bone mineral density; CESC cis rs992157 0.965 rs13427681 chr2:219167563 G/C cg00012203 chr2:219082015 ARPC2 0.84 11.74 0.58 6.6e-26 Colorectal cancer; CESC cis rs7621025 0.500 rs16844241 chr3:136635171 A/G cg15507776 chr3:136538369 TMEM22 -0.74 -8.58 -0.47 8.14e-16 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs11122272 0.735 rs2250719 chr1:231486208 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -6.97 -0.39 2.52e-11 Hemoglobin concentration; CESC cis rs4141404 0.923 rs2413046 chr22:31665909 C/A cg00478049 chr22:31556069 RNF185 0.45 5.16 0.3 4.89e-7 Paclitaxel-induced neuropathy; CESC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.65 9.04 0.49 3.4e-17 Menopause (age at onset); CESC cis rs2549003 1.000 rs2549007 chr5:131826875 T/C cg21138405 chr5:131827807 IRF1 -0.6 -10.77 -0.55 1.14e-22 Asthma (sex interaction); CESC cis rs10242455 0.702 rs74416635 chr7:99180569 G/A cg25640893 chr7:99214727 ZNF498 0.7 5.13 0.3 5.53e-7 Blood metabolite levels; CESC cis rs72781680 0.566 rs6714016 chr2:23899948 A/G cg08917208 chr2:24149416 ATAD2B 0.76 7.38 0.41 2.03e-12 Lymphocyte counts; CESC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg11859384 chr17:80120422 CCDC57 0.43 5.91 0.34 1.02e-8 Life satisfaction; CESC cis rs2249694 0.920 rs1536826 chr10:135357239 A/C cg20169779 chr10:135381914 SYCE1 0.45 6.27 0.36 1.48e-9 Obesity-related traits; CESC cis rs1878931 0.615 rs4786412 chr16:3440390 C/T cg22508957 chr16:3507546 NAT15 -0.4 -5.93 -0.34 9.63e-9 Body mass index (adult); CESC cis rs1009170 0.794 rs12589375 chr14:92584380 T/C cg10324096 chr14:92587714 CPSF2;NDUFB1 0.54 5.07 0.3 7.36e-7 Dialysis-related mortality; CESC cis rs1034435 0.723 rs713946 chr22:48891376 T/C cg05992904 chr22:48892994 FAM19A5 -0.58 -10.27 -0.53 4.66e-21 Late-onset Alzheimer's disease; CESC cis rs7927771 0.524 rs9633830 chr11:47849470 T/G cg20307385 chr11:47447363 PSMC3 0.62 8.62 0.47 6.37e-16 Subjective well-being; CESC cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.5 8.67 0.47 4.51e-16 Monocyte percentage of white cells; CESC trans rs1814175 0.817 rs10839358 chr11:49770972 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.96 -0.77 1.02e-54 Height; CESC cis rs9640161 0.789 rs1464752 chr7:150021284 C/T cg21361702 chr7:150065534 REPIN1 0.5 5.72 0.33 2.8e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs4268898 0.662 rs2303291 chr2:24431184 C/T cg06627628 chr2:24431161 ITSN2 -1.01 -10.88 -0.56 5.09e-23 Asthma; CESC cis rs9611565 0.921 rs2143695 chr22:41728620 A/G cg03806693 chr22:41940476 POLR3H -0.71 -8.55 -0.47 9.8e-16 Vitiligo; CESC cis rs3820928 0.874 rs10174073 chr2:227794944 A/G cg05526886 chr2:227700861 RHBDD1 -0.47 -6.06 -0.35 4.56e-9 Pulmonary function; CESC cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg24110177 chr3:50126178 RBM5 -0.53 -7.23 -0.41 5.13e-12 Intelligence (multi-trait analysis); CESC cis rs11638352 1.000 rs2733221 chr15:44389870 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.71 -5.15 -0.3 5.13e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs7959452 1.000 rs7959452 chr12:69735492 A/G cg14784868 chr12:69753453 YEATS4 0.57 7.62 0.42 4.46e-13 Blood protein levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11038604 chr10:14996337 DCLRE1C -0.45 -6.0 -0.35 6.3e-9 Gut microbiota (bacterial taxa); CESC cis rs4654899 0.865 rs12406144 chr1:21347228 A/C cg05370193 chr1:21551575 ECE1 0.43 6.21 0.36 2.09e-9 Superior frontal gyrus grey matter volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11059266 chr4:48782139 FRYL 0.57 6.36 0.36 8.57e-10 Gut microbiome composition (summer); CESC cis rs6460942 0.597 rs13245635 chr7:12526454 T/A cg06484146 chr7:12443880 VWDE -0.71 -7.69 -0.43 2.88e-13 Coronary artery disease; CESC cis rs5753618 0.529 rs5749298 chr22:31941032 C/T cg13145458 chr22:31556086 RNF185 -0.5 -5.84 -0.34 1.5e-8 Colorectal cancer; CESC cis rs611744 0.529 rs13282825 chr8:109263237 T/C cg21045802 chr8:109455806 TTC35 0.46 5.7 0.33 3.13e-8 Dupuytren's disease; CESC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.03 -0.3 8.96e-7 Breast cancer; CESC cis rs2011503 1.000 rs8105642 chr19:19558468 G/A cg11584989 chr19:19387371 SF4 0.61 7.08 0.4 1.3e-11 Bipolar disorder; CESC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg12963246 chr6:28129442 ZNF389 0.59 7.7 0.43 2.7e-13 Depression; CESC cis rs12618769 0.597 rs72821920 chr2:99111591 A/G cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs7044106 0.791 rs4836831 chr9:123496570 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.89 14.39 0.66 4.47e-35 Hip circumference adjusted for BMI; CESC cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg23583168 chr7:148888333 NA -0.73 -10.69 -0.55 2.02e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs10089 1.000 rs10463838 chr5:127518305 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.48 0.5 1.53e-18 Ileal carcinoids; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg01163298 chr12:49393408 DDN -0.45 -6.25 -0.36 1.67e-9 Breast cancer;Type 2 diabetes; CESC trans rs6934970 0.860 rs6921006 chr6:112986439 G/A cg05146922 chr2:10634174 NA -0.37 -6.17 -0.35 2.53e-9 Bipolar disorder (body mass index interaction); CESC cis rs2904967 0.526 rs171193 chr11:64982599 A/G cg01213895 chr11:65029414 POLA2 -0.46 -5.24 -0.31 3.33e-7 Mean corpuscular volume; CESC cis rs79349575 0.749 rs957557 chr17:47003221 G/T cg16584676 chr17:46985605 UBE2Z 0.54 6.7 0.38 1.24e-10 Type 2 diabetes; CESC cis rs7917772 0.503 rs11191321 chr10:104293412 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -5.97 -0.34 7.47e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2439831 0.850 rs2957637 chr15:43951118 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.81 8.23 0.45 8.46e-15 Lung cancer in ever smokers; CESC cis rs4474465 0.833 rs10793320 chr11:78217460 G/A cg27205649 chr11:78285834 NARS2 0.45 5.58 0.32 5.97e-8 Alzheimer's disease (survival time); CESC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg06420487 chr17:61919686 SMARCD2 0.43 5.12 0.3 5.8e-7 Height; CESC cis rs4718428 0.672 rs13241598 chr7:66300652 A/G cg25985355 chr7:65971099 NA -0.34 -5.04 -0.3 8.6e-7 Corneal structure; CESC trans rs1814175 0.647 rs61306292 chr11:49856040 G/C cg03929089 chr4:120376271 NA -0.92 -15.68 -0.69 1.2e-39 Height; CESC cis rs7131987 0.903 rs11050161 chr12:29420049 A/G cg09582351 chr12:29534625 ERGIC2 -0.34 -5.39 -0.31 1.57e-7 QT interval; CESC cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.66 -8.0 -0.44 3.9e-14 Multiple sclerosis; CESC cis rs8062405 0.755 rs62034350 chr16:28562256 A/G cg01378222 chr16:28622494 SULT1A1 0.31 5.14 0.3 5.27e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9913156 0.707 rs11657052 chr17:4570573 C/T cg00122941 chr17:4613640 ARRB2 -0.79 -9.64 -0.51 4.84e-19 Lymphocyte counts; CESC cis rs849898 1 rs849898 chr1:228153917 A/G cg02753203 chr1:228287806 NA -0.71 -10.11 -0.53 1.6e-20 Parkinson's disease; CESC cis rs2243480 1.000 rs34577383 chr7:65385726 C/T cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC cis rs6688613 0.694 rs1476347 chr1:166815587 G/T ch.1.3259774R chr1:166827647 TADA1 0.62 6.35 0.36 9.23e-10 Refractive astigmatism; CESC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.79 10.49 0.54 9.34e-22 Height; CESC cis rs8078723 0.966 rs2227322 chr17:38171668 C/G cg17467752 chr17:38218738 THRA 0.66 9.82 0.52 1.25e-19 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs7580658 0.895 rs7589451 chr2:128128775 T/C cg10021288 chr2:128175891 PROC -0.4 -6.38 -0.36 8.05e-10 Protein C levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg27651003 chr16:67261081 TMEM208;LRRC29 -0.47 -6.81 -0.39 6.67e-11 Asthma; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg05214047 chr5:56112645 MAP3K1 0.49 6.55 0.37 2.98e-10 Systemic lupus erythematosus; CESC cis rs8060686 0.516 rs8048364 chr16:68253324 T/G cg26727032 chr16:67993705 SLC12A4 -0.59 -8.5 -0.46 1.38e-15 HDL cholesterol;Metabolic syndrome; CESC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg07157834 chr1:205819609 PM20D1 0.73 10.58 0.54 4.79e-22 Menarche (age at onset); CESC cis rs8141529 0.664 rs5762862 chr22:29252732 C/T cg02153584 chr22:29168773 CCDC117 0.53 6.51 0.37 3.78e-10 Lymphocyte counts; CESC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg25405998 chr7:65216604 CCT6P1 -0.46 -5.2 -0.3 3.9e-7 Aortic root size; CESC cis rs2455799 0.573 rs2654650 chr3:15779214 C/T cg16303742 chr3:15540471 COLQ -0.39 -6.13 -0.35 3.12e-9 Mean platelet volume; CESC cis rs4077515 0.839 rs3812563 chr9:139271106 A/G cg14169450 chr9:139327907 INPP5E 0.41 5.87 0.34 1.31e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs8060686 0.641 rs8064114 chr16:68240185 G/A cg26727032 chr16:67993705 SLC12A4 -0.51 -6.11 -0.35 3.5e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs10878577 0.813 rs4913531 chr12:67584661 C/T cg07881065 chr8:840398 NA 0.37 6.06 0.35 4.66e-9 Schizophrenia; CESC cis rs6460942 0.659 rs13247187 chr7:12551851 T/C cg06484146 chr7:12443880 VWDE -0.7 -7.59 -0.42 5.46e-13 Coronary artery disease; CESC cis rs929354 0.935 rs1182392 chr7:157036200 C/T cg05182265 chr7:156933206 UBE3C 0.4 5.57 0.32 6.19e-8 Body mass index; CESC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg00166722 chr3:10149974 C3orf24 0.51 6.38 0.37 7.76e-10 Alzheimer's disease; CESC cis rs4930103 0.935 rs4930101 chr11:2021859 G/T cg23202291 chr11:1979235 NA 0.37 5.38 0.31 1.62e-7 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs1348850 0.768 rs57681892 chr2:178357645 G/C cg22681709 chr2:178499509 PDE11A -0.43 -6.31 -0.36 1.19e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs425277 1.000 rs55826501 chr1:2059143 G/A cg24578937 chr1:2090814 PRKCZ 0.52 8.72 0.47 3.02e-16 Height; CESC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg12419862 chr22:24373484 LOC391322 -0.81 -11.98 -0.59 1.04e-26 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs10776614 0.799 rs7098068 chr10:49763717 C/T cg19218067 chr2:181235115 NA 0.5 6.29 0.36 1.27e-9 Self-employment; CESC cis rs9399137 0.529 rs7739722 chr6:135282225 T/C cg22676075 chr6:135203613 NA 0.55 7.15 0.4 8.61e-12 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg03576123 chr11:487126 PTDSS2 -1.08 -10.51 -0.54 7.9e-22 Body mass index; CESC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg01939980 chr4:1354348 KIAA1530 0.43 5.35 0.31 1.88e-7 Longevity; CESC cis rs62064224 0.614 rs4795700 chr17:30763794 A/G cg18200150 chr17:30822561 MYO1D 0.42 5.41 0.32 1.43e-7 Schizophrenia; CESC cis rs921968 0.643 rs13431399 chr2:219469498 G/C cg02176678 chr2:219576539 TTLL4 -0.52 -8.96 -0.48 6.06e-17 Mean corpuscular hemoglobin concentration; CESC cis rs763121 0.853 rs6519124 chr22:39045099 T/C cg21395723 chr22:39101663 GTPBP1 0.5 6.66 0.38 1.6e-10 Menopause (age at onset); CESC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg23161317 chr6:28129485 ZNF389 0.44 5.72 0.33 2.8e-8 Depression; CESC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg22535103 chr8:58192502 C8orf71 -0.92 -9.13 -0.49 1.84e-17 Developmental language disorder (linguistic errors); CESC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.76 0.33 2.3e-8 Menopause (age at onset); CESC cis rs3733585 0.674 rs7375643 chr4:9955239 A/G cg02734326 chr4:10020555 SLC2A9 -0.46 -6.94 -0.39 3.08e-11 Cleft plate (environmental tobacco smoke interaction); CESC trans rs1728785 1.000 rs12925177 chr16:68569645 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.6 -7.4 -0.41 1.76e-12 Ulcerative colitis; CESC cis rs3733585 0.673 rs9994937 chr4:9964799 G/T cg00071950 chr4:10020882 SLC2A9 -0.74 -11.9 -0.59 1.84e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs75477785 1.000 rs4844908 chr1:210054718 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.8 5.19 0.3 4.2e-7 Cleft lip with or without cleft palate; CESC cis rs6121246 0.567 rs6120815 chr20:30184866 T/C cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs11864453 0.713 rs8051882 chr16:72142072 A/G cg01557791 chr16:72042693 DHODH 0.48 6.15 0.35 2.79e-9 Fibrinogen levels; CESC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg22800045 chr5:56110881 MAP3K1 0.44 5.38 0.31 1.6e-7 Coronary artery disease; CESC cis rs977987 0.843 rs12149063 chr16:75451758 G/A cg03315344 chr16:75512273 CHST6 0.41 5.84 0.34 1.56e-8 Dupuytren's disease; CESC cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.05 0.35 4.95e-9 Colorectal cancer; CESC cis rs1538970 1.000 rs4660852 chr1:45848931 A/C cg06784218 chr1:46089804 CCDC17 -0.32 -5.47 -0.32 1.07e-7 Platelet count; CESC cis rs1322639 0.697 rs12661910 chr6:169584388 A/G cg04662567 chr6:169592167 NA -0.5 -5.5 -0.32 8.85e-8 Pulse pressure; CESC cis rs9611565 0.506 rs1883825 chr22:41703408 A/G cg06481639 chr22:41940642 POLR3H -0.49 -5.57 -0.32 6.21e-8 Vitiligo; CESC cis rs7568458 0.660 rs6722691 chr2:85758352 C/T cg02493740 chr2:85810744 VAMP5 -0.57 -8.4 -0.46 2.81e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC trans rs877282 0.853 rs12779017 chr10:763619 T/C cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs5753037 0.653 rs131265 chr22:30145591 C/T cg01021169 chr22:30184971 ASCC2 -0.47 -6.6 -0.38 2.17e-10 Type 1 diabetes; CESC cis rs477692 0.673 rs511361 chr10:131365052 C/T cg05714579 chr10:131428358 MGMT 0.4 5.15 0.3 4.97e-7 Response to temozolomide; CESC cis rs9303401 0.614 rs12948536 chr17:56580413 G/T cg25039879 chr17:56429692 SUPT4H1 0.51 5.11 0.3 6.24e-7 Cognitive test performance; CESC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -11.61 -0.58 1.83e-25 Alzheimer's disease; CESC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg25124228 chr12:125621409 AACS -0.5 -5.82 -0.34 1.73e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs55986470 0.817 rs6710301 chr2:239441308 A/C cg18131467 chr2:239335373 ASB1 0.6 5.29 0.31 2.59e-7 Chronotype; CESC cis rs4654899 0.865 rs6426658 chr1:21361176 G/A cg05370193 chr1:21551575 ECE1 0.41 6.23 0.36 1.82e-9 Superior frontal gyrus grey matter volume; CESC cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg06970220 chr1:156163860 SLC25A44 0.39 5.22 0.31 3.67e-7 Testicular germ cell tumor; CESC cis rs4409675 0.597 rs1467464 chr1:28211650 T/C cg11176159 chr1:28213800 NA 0.23 5.09 0.3 6.87e-7 Corneal astigmatism; CESC trans rs13402330 1.000 rs10181783 chr2:103509684 G/A cg14228246 chr9:132165670 NA 0.46 6.05 0.35 4.9e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs910316 0.935 rs3742771 chr14:75599647 A/G cg11812906 chr14:75593930 NEK9 0.89 15.03 0.68 2.4e-37 Height; CESC cis rs8180040 0.715 rs6772670 chr3:47191349 G/A cg27129171 chr3:47204927 SETD2 0.69 10.44 0.54 1.33e-21 Colorectal cancer; CESC cis rs3105593 1.000 rs4509958 chr15:50894175 T/C cg08437265 chr15:50716283 USP8 0.41 5.22 0.31 3.57e-7 QT interval; CESC cis rs4853012 1.000 rs4853012 chr2:74361290 G/A cg20891558 chr2:74357851 NA 0.8 9.47 0.5 1.62e-18 Gestational age at birth (maternal effect); CESC trans rs11098499 0.754 rs1511025 chr4:120240238 T/C cg25214090 chr10:38739885 LOC399744 0.61 8.51 0.46 1.33e-15 Corneal astigmatism; CESC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.06 10.39 0.54 1.98e-21 Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07130416 chr16:2052619 ZNF598 0.48 6.3 0.36 1.24e-9 Fibrinogen levels; CESC cis rs12711979 0.765 rs881852 chr2:3821508 A/G cg17052675 chr2:3827356 NA -0.37 -5.72 -0.33 2.83e-8 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs9435341 0.965 rs1762482 chr1:107599002 A/C cg09367891 chr1:107599246 PRMT6 -0.61 -7.51 -0.42 9.27e-13 Facial morphology (factor 21, depth of nasal alae); CESC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg26338869 chr17:61819248 STRADA 0.63 8.16 0.45 1.32e-14 Prudent dietary pattern; CESC cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg15557168 chr22:42548783 NA -0.46 -6.5 -0.37 4e-10 Schizophrenia; CESC trans rs7618501 0.571 rs2240329 chr3:50107512 G/A cg21659725 chr3:3221576 CRBN -0.49 -6.92 -0.39 3.38e-11 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00206853 chr16:3647862 BTBD12 0.43 6.21 0.36 2.03e-9 Fibrinogen levels; CESC cis rs9473147 0.543 rs4715025 chr6:47483653 C/G cg20196966 chr6:47445060 CD2AP 0.41 5.33 0.31 2.13e-7 Platelet distribution width;Mean platelet volume; CESC cis rs7089973 0.604 rs1924034 chr10:116578539 C/T cg03647239 chr10:116582469 FAM160B1 0.44 5.67 0.33 3.78e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs208520 0.837 rs208488 chr6:66926902 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.87 -10.08 -0.53 1.88e-20 Exhaled nitric oxide output; CESC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg06074448 chr4:187884817 NA -0.37 -5.22 -0.31 3.6e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg15445000 chr17:37608096 MED1 0.4 6.45 0.37 5.28e-10 Glomerular filtration rate (creatinine); CESC cis rs3767633 0.528 rs4417044 chr1:161888955 T/C cg27519958 chr1:161735129 ATF6 -0.48 -6.02 -0.35 5.83e-9 IgG glycosylation; CESC cis rs4076764 0.958 rs6688997 chr1:163411562 G/A cg06092702 chr1:163392909 NA -0.41 -5.92 -0.34 9.92e-9 Motion sickness; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14361641 chr2:70056642 GMCL1 -0.47 -6.75 -0.38 9.18e-11 Gambling; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16629569 chr3:122513933 DIRC2;HSPBAP1 -0.47 -6.07 -0.35 4.45e-9 Asthma; CESC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.91e-8 Lung cancer; CESC cis rs1023500 0.551 rs2854837 chr22:42458481 G/A cg04733989 chr22:42467013 NAGA 0.75 10.83 0.55 7.23e-23 Schizophrenia; CESC cis rs2046867 0.818 rs6786469 chr3:72873809 A/G cg25664220 chr3:72788482 NA -0.45 -6.09 -0.35 4e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs7572263 0.724 rs6749281 chr2:209050696 C/A cg23998903 chr2:209048830 C2orf80 -0.39 -5.14 -0.3 5.4e-7 Glioma;Non-glioblastoma glioma; CESC cis rs7647973 0.577 rs6446247 chr3:49102001 A/T cg07636037 chr3:49044803 WDR6 0.86 11.4 0.57 9.24e-25 Menarche (age at onset); CESC cis rs1348850 0.668 rs2365619 chr2:178497366 A/G cg22681709 chr2:178499509 PDE11A 0.47 6.42 0.37 6.34e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9858542 0.953 rs7633271 chr3:49555963 T/C cg07274523 chr3:49395745 GPX1 0.66 8.5 0.46 1.37e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs10206020 0.885 rs11887527 chr2:1578080 A/G cg12573674 chr2:1569213 NA -0.45 -5.18 -0.3 4.5e-7 IgG glycosylation; CESC cis rs3733585 0.664 rs17185870 chr4:9958214 C/A cg00071950 chr4:10020882 SLC2A9 -0.72 -11.54 -0.58 3.14e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4969178 0.641 rs4969141 chr17:76391653 C/T cg05887092 chr17:76393375 PGS1 0.68 11.55 0.58 2.99e-25 HDL cholesterol levels; CESC trans rs1814175 0.587 rs7937757 chr11:49978342 G/A cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs9614461 0.702 rs16993867 chr22:45733199 A/G cg15911859 chr22:45810043 RIBC2;SMC1B 0.6 7.03 0.4 1.7e-11 Tonsillectomy; CESC trans rs61931739 0.500 rs7309421 chr12:34553795 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.49 0.37 4.16e-10 Morning vs. evening chronotype; CESC trans rs116095464 0.558 rs28418643 chr5:240859 A/G cg00938859 chr5:1591904 SDHAP3 0.64 6.99 0.39 2.27e-11 Breast cancer; CESC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg15445000 chr17:37608096 MED1 -0.4 -6.61 -0.38 2.1e-10 Glomerular filtration rate (creatinine); CESC cis rs1003719 0.641 rs13046844 chr21:38517603 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -8.06 -0.44 2.56e-14 Eye color traits; CESC cis rs2075671 0.903 rs62483570 chr7:100300649 C/T cg20848291 chr7:100343083 ZAN -0.79 -9.89 -0.52 7.81e-20 Other erythrocyte phenotypes; CESC trans rs5756813 0.754 rs4820307 chr22:38175955 G/A cg19894588 chr14:64061835 NA -0.68 -8.83 -0.48 1.45e-16 Optic cup area;Vertical cup-disc ratio; CESC cis rs35110281 0.712 rs1454648 chr21:45053815 C/T cg01579765 chr21:45077557 HSF2BP -0.55 -9.1 -0.49 2.31e-17 Mean corpuscular volume; CESC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg06808227 chr14:105710500 BRF1 -0.62 -7.91 -0.44 7.23e-14 Mean platelet volume;Platelet distribution width; CESC cis rs1348850 0.561 rs57986285 chr2:178468663 C/T cg22681709 chr2:178499509 PDE11A -0.47 -5.14 -0.3 5.22e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6736093 0.966 rs870761 chr2:112745290 A/T cg12686935 chr2:112915763 FBLN7 -0.43 -5.61 -0.33 5.09e-8 Coronary artery disease; CESC cis rs5769765 0.862 rs138856 chr22:50199378 G/T cg02269571 chr22:50332266 NA -0.46 -5.72 -0.33 2.9e-8 Schizophrenia; CESC cis rs7617773 0.780 rs3197223 chr3:48335857 C/T cg11946769 chr3:48343235 NME6 0.87 11.45 0.58 6.11e-25 Coronary artery disease; CESC cis rs881375 0.692 rs2072438 chr9:123651301 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 7.85 0.43 1.01e-13 Rheumatoid arthritis; CESC cis rs28647808 0.881 rs4962139 chr9:136267869 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A -0.96 -8.2 -0.45 1.02e-14 Blood protein levels; CESC trans rs882300 0.758 rs10191360 chr2:136884679 A/G cg11058932 chr7:130372167 TSGA13 0.4 6.06 0.35 4.71e-9 Multiple sclerosis;Electrocardiographic traits; CESC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg03396347 chr1:1875803 NA -0.43 -6.67 -0.38 1.46e-10 Body mass index; CESC cis rs4481887 0.861 rs6669290 chr1:248476804 G/A cg00666640 chr1:248458726 OR2T12 0.35 5.89 0.34 1.17e-8 Common traits (Other); CESC cis rs2832191 0.791 rs9983651 chr21:30491227 T/A cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.63e-20 Dental caries; CESC cis rs13096760 1 rs13096760 chr3:49476806 T/C cg07636037 chr3:49044803 WDR6 0.61 8.83 0.48 1.42e-16 Intelligence (multi-trait analysis); CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg05564831 chr3:52568323 NT5DC2 0.48 8.13 0.45 1.63e-14 Bipolar disorder; CESC cis rs2404618 0.593 rs7829532 chr8:1485190 C/A cg02903104 chr8:1507517 DLGAP2 0.29 5.42 0.32 1.37e-7 Lung cancer; CESC cis rs7188697 0.848 rs42947 chr16:58579158 A/C cg02549819 chr16:58548995 SETD6 -0.43 -5.47 -0.32 1.03e-7 QT interval; CESC cis rs2243480 1.000 rs34560516 chr7:65404092 A/T cg12463550 chr7:65579703 CRCP 0.71 5.5 0.32 8.79e-8 Diabetic kidney disease; CESC cis rs7584330 0.910 rs72620830 chr2:238396985 C/T cg14458575 chr2:238380390 NA 0.69 10.02 0.52 3.03e-20 Prostate cancer; CESC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg14703610 chr5:56206110 C5orf35 -0.42 -5.13 -0.3 5.69e-7 Coronary artery disease; CESC cis rs6580649 0.941 rs1793931 chr12:48396505 G/T cg05342945 chr12:48394962 COL2A1 -0.54 -6.44 -0.37 5.55e-10 Lung cancer; CESC cis rs7246657 0.943 rs7255952 chr19:37988797 A/G cg23950597 chr19:37808831 NA -0.58 -6.34 -0.36 1e-9 Coronary artery calcification; CESC cis rs3820928 1.000 rs10210763 chr2:227776029 G/T cg05526886 chr2:227700861 RHBDD1 -0.42 -5.54 -0.32 7.19e-8 Pulmonary function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00729291 chr7:38725630 FAM183B 0.5 7.24 0.41 4.73e-12 Fibrinogen levels; CESC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg19445457 chr11:5799446 OR52N5 -0.39 -5.27 -0.31 2.8e-7 DNA methylation (variation); CESC trans rs9929218 0.954 rs9646284 chr16:68791306 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.02 -0.44 3.45e-14 Colorectal cancer; CESC cis rs2070488 1.000 rs2268753 chr3:38500189 C/T cg24069376 chr3:38537580 EXOG 0.48 8.8 0.48 1.8e-16 Electrocardiographic conduction measures; CESC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg04369109 chr6:150039330 LATS1 -0.43 -5.88 -0.34 1.26e-8 Lung cancer; CESC cis rs7582720 1.000 rs72928608 chr2:203836507 G/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.88e-10 Life satisfaction; CESC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg22823121 chr1:150693482 HORMAD1 -0.46 -6.47 -0.37 4.69e-10 Melanoma; CESC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg26343298 chr8:95960752 TP53INP1 0.32 5.27 0.31 2.78e-7 Type 2 diabetes; CESC cis rs738322 0.836 rs4821741 chr22:38514745 A/G cg17652424 chr22:38574118 PLA2G6 -0.29 -5.1 -0.3 6.59e-7 Cutaneous nevi; CESC cis rs9611565 0.921 rs3927 chr22:41722864 A/G cg17376030 chr22:41985996 PMM1 0.58 6.29 0.36 1.31e-9 Vitiligo; CESC cis rs1801251 0.896 rs79793315 chr2:233690864 C/T cg08000102 chr2:233561755 GIGYF2 -0.72 -11.48 -0.58 5.05e-25 Coronary artery disease; CESC cis rs722599 1.000 rs722599 chr14:75327443 T/C cg08847533 chr14:75593920 NEK9 -0.45 -5.68 -0.33 3.53e-8 IgG glycosylation; CESC cis rs741677 0.964 rs8077122 chr17:495522 G/A cg06217071 chr17:408420 NA -0.31 -5.11 -0.3 6.32e-7 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); CESC cis rs7598759 0.548 rs1584462 chr2:232369798 A/G cg19187155 chr2:232395269 NMUR1 0.61 10.3 0.53 3.88e-21 Noise-induced hearing loss; CESC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg01448562 chr3:133502909 NA 0.4 5.55 0.32 6.79e-8 Iron status biomarkers; CESC cis rs929596 0.785 rs17864701 chr2:234652717 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.69 -8.59 -0.47 7.64e-16 Total bilirubin levels in HIV-1 infection; CESC cis rs9287719 0.967 rs4453662 chr2:10739128 G/A cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs10751667 0.643 rs10902234 chr11:935578 A/G cg01483505 chr11:975446 AP2A2 0.38 5.27 0.31 2.8e-7 Alzheimer's disease (late onset); CESC cis rs7772486 0.875 rs2814877 chr6:146299763 C/G cg05347473 chr6:146136440 FBXO30 0.55 7.19 0.4 6.54e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs4654899 0.932 rs10916943 chr1:21472429 T/C cg05370193 chr1:21551575 ECE1 -0.38 -5.75 -0.33 2.4e-8 Superior frontal gyrus grey matter volume; CESC cis rs2479724 0.875 rs2253961 chr6:41827011 A/G cg17623882 chr6:41773611 USP49 -0.41 -5.77 -0.33 2.26e-8 Menarche (age at onset); CESC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg00684032 chr4:1343700 KIAA1530 0.49 6.98 0.39 2.31e-11 Obesity-related traits; CESC cis rs524281 0.861 rs10791856 chr11:65964650 T/C cg14036092 chr11:66035641 RAB1B -0.5 -5.48 -0.32 9.95e-8 Electroencephalogram traits; CESC cis rs2204008 0.749 rs4579984 chr12:38166266 A/G cg13010199 chr12:38710504 ALG10B 0.49 6.07 0.35 4.34e-9 Bladder cancer; CESC cis rs9478638 0.507 rs2184406 chr6:155629678 T/C cg07943832 chr6:155568918 TIAM2 -0.37 -5.49 -0.32 9.33e-8 Electroencephalogram traits; CESC cis rs1559088 0.895 rs1974784 chr19:33551563 T/G cg27124370 chr19:33622961 WDR88 0.42 5.33 0.31 2.14e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs61931739 0.500 rs11053261 chr12:34530810 C/T cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs754466 0.580 rs10824571 chr10:79531931 G/A cg17075019 chr10:79541650 NA -0.89 -13.81 -0.65 4.92e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs11190604 1.000 rs3750626 chr10:102266316 C/T cg07080220 chr10:102295463 HIF1AN 0.64 5.88 0.34 1.23e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03616030 chr8:94766944 TMEM67 -0.5 -6.24 -0.36 1.7e-9 Gut microbiome composition (summer); CESC cis rs7937682 0.924 rs499750 chr11:111513645 T/G cg22437258 chr11:111473054 SIK2 0.69 9.23 0.49 8.64e-18 Primary sclerosing cholangitis; CESC cis rs2637266 1.000 rs1873461 chr10:78338966 A/C cg18941641 chr10:78392320 NA -0.43 -8.02 -0.44 3.32e-14 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02399233 chr11:71201915 NADSYN1 -0.57 -6.16 -0.35 2.66e-9 Gut microbiome composition (summer); CESC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg11644478 chr21:40555479 PSMG1 -0.56 -7.12 -0.4 9.97e-12 Menarche (age at onset); CESC cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.78e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4704187 0.687 rs10079346 chr5:74536655 G/A cg03227963 chr5:74354835 NA 0.27 5.04 0.3 8.67e-7 Response to amphetamines; CESC cis rs6580649 1.000 rs6580649 chr12:48410517 A/G cg24011408 chr12:48396354 COL2A1 0.44 5.51 0.32 8.58e-8 Lung cancer; CESC cis rs2243480 1.000 rs160637 chr7:65584318 C/T cg18252515 chr7:66147081 NA -1.39 -13.92 -0.65 1.93e-33 Diabetic kidney disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12052203 chr11:66115045 B3GNT1 -0.47 -6.24 -0.36 1.7e-9 Fibrinogen levels; CESC trans rs17685 0.712 rs6953342 chr7:75776753 T/C cg19862616 chr7:65841803 NCRNA00174 0.8 11.44 0.57 6.89e-25 Coffee consumption;Coffee consumption (cups per day); CESC cis rs11098499 0.754 rs878372 chr4:120238780 A/C cg09307838 chr4:120376055 NA 0.79 10.77 0.55 1.17e-22 Corneal astigmatism; CESC cis rs7395581 0.798 rs10769252 chr11:47343955 A/G cg25783544 chr11:47291846 MADD 0.61 7.88 0.44 8.49e-14 HDL cholesterol; CESC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg24881330 chr22:46731750 TRMU 0.82 7.29 0.41 3.49e-12 LDL cholesterol;Cholesterol, total; CESC cis rs708547 0.836 rs1612191 chr4:57724320 A/C cg25525207 chr4:57843836 C4orf14;POLR2B 0.49 5.06 0.3 7.85e-7 Response to bleomycin (chromatid breaks); CESC cis rs6594499 0.500 rs12514810 chr5:110455357 T/A cg04022379 chr5:110408740 TSLP 0.41 6.94 0.39 3.02e-11 Allergic disease (asthma, hay fever or eczema); CESC cis rs11608355 0.515 rs61941591 chr12:109919965 A/C cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs3733585 0.699 rs7686538 chr4:9948077 C/T cg11266682 chr4:10021025 SLC2A9 -0.59 -11.08 -0.56 1.03e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg12386194 chr3:101231763 SENP7 0.49 5.96 0.34 7.84e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg08470875 chr2:26401718 FAM59B -0.73 -8.0 -0.44 3.99e-14 Gut microbiome composition (summer); CESC cis rs7824557 0.583 rs2736292 chr8:11234500 A/T cg21775007 chr8:11205619 TDH 0.53 8.24 0.45 8.16e-15 Retinal vascular caliber; CESC cis rs13256369 0.853 rs13256216 chr8:8577883 C/T cg00074818 chr8:8560427 CLDN23 0.41 5.99 0.35 6.78e-9 Obesity-related traits; CESC cis rs523522 0.923 rs10774553 chr12:120954984 T/C cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg08736216 chr1:53307985 ZYG11A 0.29 5.04 0.3 8.51e-7 Monocyte count; CESC cis rs9584850 0.794 rs72655609 chr13:99128622 C/G cg20750642 chr13:99100586 FARP1 -0.38 -5.59 -0.32 5.57e-8 Neuroticism; CESC cis rs7116495 0.609 rs10898812 chr11:71698801 G/A cg26138937 chr11:71823887 C11orf51 -1.26 -8.07 -0.44 2.43e-14 Severe influenza A (H1N1) infection; CESC cis rs7216064 1.000 rs55939964 chr17:65869297 G/A cg07042672 chr17:66097459 LOC651250 -0.54 -5.59 -0.32 5.61e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.14 -0.3 5.22e-7 Lung cancer; CESC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg01416388 chr22:39784598 NA -0.51 -5.95 -0.34 8.5e-9 Intelligence (multi-trait analysis); CESC cis rs12541635 0.966 rs7812766 chr8:107057033 G/A cg10147462 chr8:107024639 NA 0.43 6.01 0.35 6.12e-9 Age of smoking initiation; CESC cis rs12928939 0.517 rs17358402 chr16:71967927 C/T cg03805757 chr16:71968109 PKD1L3 -0.59 -6.62 -0.38 2.01e-10 Post bronchodilator FEV1; CESC cis rs9790314 1.000 rs7638668 chr3:161047283 G/A cg03342759 chr3:160939853 NMD3 -0.47 -6.11 -0.35 3.61e-9 Morning vs. evening chronotype; CESC cis rs3762637 0.943 rs10439995 chr3:122189160 C/A cg24169773 chr3:122142474 KPNA1 -0.53 -6.17 -0.35 2.56e-9 LDL cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26996779 chr5:69784092 NA -0.47 -6.1 -0.35 3.71e-9 Gut microbiome composition (summer); CESC cis rs12780046 0.536 rs7092010 chr10:101006228 G/A cg27143070 chr10:101087766 CNNM1 0.38 5.63 0.33 4.7e-8 Non-glioblastoma glioma; CESC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.08 -0.4 1.26e-11 Gut microbiome composition (summer); CESC cis rs1957429 0.520 rs72625648 chr14:65344602 A/G cg23373153 chr14:65346875 NA -0.85 -6.5 -0.37 3.94e-10 Pediatric areal bone mineral density (radius); CESC cis rs11098499 1.000 rs11726229 chr4:120211580 C/T cg24375607 chr4:120327624 NA 0.42 5.03 0.3 8.94e-7 Corneal astigmatism; CESC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.87 0.44 8.81e-14 Menopause (age at onset); CESC cis rs2251381 0.778 rs2245021 chr21:30546841 C/T cg08807101 chr21:30365312 RNF160 0.67 8.23 0.45 8.77e-15 Selective IgA deficiency; CESC trans rs1814175 0.616 rs1794131 chr11:49904194 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg03806693 chr22:41940476 POLR3H -1.01 -11.77 -0.59 5.31e-26 Vitiligo; CESC cis rs72781680 1.000 rs72798411 chr2:24184343 A/G cg08917208 chr2:24149416 ATAD2B 1.11 10.02 0.52 3.07e-20 Lymphocyte counts; CESC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg06456125 chr7:65229604 NA -0.41 -5.41 -0.32 1.4e-7 Aortic root size; CESC cis rs854765 0.583 rs7214536 chr17:17852446 G/A cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC trans rs801193 1.000 rs2707850 chr7:66203870 G/T cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05775796 chr11:67719813 NA -0.55 -7.28 -0.41 3.89e-12 Gut microbiome composition (summer); CESC cis rs17533156 0.557 rs16969683 chr17:75128195 A/G cg18815765 chr17:75136729 SEC14L1 -0.43 -5.07 -0.3 7.52e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.21 0.3 3.83e-7 Bipolar disorder; CESC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg25985355 chr7:65971099 NA 0.33 5.41 0.32 1.39e-7 Aortic root size; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05730215 chr2:27435253 SLC5A6;C2orf28 -0.46 -6.34 -0.36 1.01e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10737909 1.000 rs10737909 chr1:15548636 A/C cg21012057 chr1:15538911 TMEM51 0.42 5.97 0.34 7.5e-9 Migraine; CESC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg24829409 chr8:58192753 C8orf71 -0.57 -6.91 -0.39 3.67e-11 Developmental language disorder (linguistic errors); CESC cis rs1983170 0.736 rs11164909 chr1:92002506 T/C cg02896835 chr1:92012615 NA 0.59 6.19 0.36 2.31e-9 Eosinophil percentage of white cells; CESC cis rs9660180 0.839 rs12040826 chr1:1705287 A/C cg13866156 chr1:1669148 SLC35E2 -0.51 -6.76 -0.38 8.91e-11 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26968203 chr17:4871318 CAMTA2;SPAG7 -0.66 -7.14 -0.4 8.71e-12 Gut microbiome composition (summer); CESC trans rs9951602 0.541 rs7243702 chr18:76645637 G/A cg02800362 chr5:177631904 HNRNPAB 0.61 7.97 0.44 4.84e-14 Obesity-related traits; CESC trans rs17764205 0.777 rs10424519 chr19:3253532 C/G cg03776506 chr16:30581384 ZNF688 0.73 6.07 0.35 4.46e-9 Bipolar disorder and schizophrenia; CESC cis rs9660180 0.967 rs61422524 chr1:1767565 C/A cg13866156 chr1:1669148 SLC35E2 -0.51 -6.72 -0.38 1.09e-10 Body mass index; CESC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg19077165 chr18:44547161 KATNAL2 -0.62 -9.27 -0.49 6.83e-18 Personality dimensions; CESC cis rs12681288 0.676 rs2600514 chr8:994175 G/A cg04851639 chr8:1020857 NA -0.34 -7.32 -0.41 3.04e-12 Schizophrenia; CESC trans rs11628318 0.802 rs2277471 chr14:103024387 A/C cg08318076 chr8:62051812 NA -0.38 -6.18 -0.35 2.42e-9 Platelet count; CESC cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg19513890 chr22:42538836 CYP2D7P1 -0.39 -5.73 -0.33 2.78e-8 Cognitive function; CESC cis rs7267979 0.966 rs2387885 chr20:25415224 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -15.87 -0.7 2.52e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs9300255 0.602 rs941305 chr12:123715266 T/C cg19016782 chr12:123741754 C12orf65 -0.5 -7.08 -0.4 1.33e-11 Neutrophil percentage of white cells; CESC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg25036284 chr2:26402008 FAM59B -0.59 -6.83 -0.39 5.71e-11 Gut microbiome composition (summer); CESC cis rs9325144 0.555 rs2387843 chr12:38711203 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.49 0.46 1.53e-15 Morning vs. evening chronotype; CESC cis rs11098499 0.542 rs7677836 chr4:120310638 T/A cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs7264396 0.563 rs2425088 chr20:34303902 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.7 0.38 1.23e-10 Total cholesterol levels; CESC cis rs1153858 1.000 rs4775895 chr15:45617957 T/A cg14582100 chr15:45693742 SPATA5L1 0.4 5.66 0.33 3.89e-8 Homoarginine levels; CESC trans rs11098499 0.865 rs10032158 chr4:120391632 C/T cg25214090 chr10:38739885 LOC399744 0.71 10.27 0.53 4.75e-21 Corneal astigmatism; CESC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg06494592 chr3:125709126 NA -0.43 -5.19 -0.3 4.19e-7 Blood pressure (smoking interaction); CESC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg01416388 chr22:39784598 NA -0.65 -7.62 -0.42 4.41e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9303401 0.614 rs3803753 chr17:56540110 G/A cg12560992 chr17:57184187 TRIM37 0.51 5.08 0.3 7.08e-7 Cognitive test performance; CESC cis rs6582630 0.502 rs2387603 chr12:38353389 A/C cg26384229 chr12:38710491 ALG10B 0.69 10.42 0.54 1.6e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg08704250 chr15:31115839 NA -0.68 -9.12 -0.49 1.97e-17 Huntington's disease progression; CESC cis rs2549003 1.000 rs6894655 chr5:131818649 T/C cg02551604 chr5:131831745 NA -0.37 -5.23 -0.31 3.45e-7 Asthma (sex interaction); CESC cis rs9916302 0.752 rs9901219 chr17:37558369 T/G cg20243544 chr17:37824526 PNMT -0.52 -5.87 -0.34 1.29e-8 Glomerular filtration rate (creatinine); CESC cis rs2262909 0.924 rs4290587 chr19:22164646 A/G cg11619707 chr19:22235551 ZNF257 -0.35 -5.82 -0.34 1.68e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs2228479 0.717 rs2074904 chr16:89811546 A/G cg14709524 chr16:89940631 TCF25 0.95 7.1 0.4 1.18e-11 Skin colour saturation; CESC cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.15e-16 Colonoscopy-negative controls vs population controls; CESC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg18404041 chr3:52824283 ITIH1 0.43 7.13 0.4 9.52e-12 Bipolar disorder; CESC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.33 -0.31 2.15e-7 Lung cancer; CESC cis rs2599510 0.783 rs2710630 chr2:32765997 A/C cg02381751 chr2:32503542 YIPF4 -0.43 -5.48 -0.32 9.76e-8 Interleukin-18 levels; CESC cis rs2795502 0.873 rs2077626 chr10:43410962 A/G cg27426351 chr10:43362370 NA 0.49 6.08 0.35 4.26e-9 Blood protein levels; CESC cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg22875332 chr1:76189707 ACADM 0.7 9.57 0.51 7.8e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.34 -5.34 -0.31 1.97e-7 Personality dimensions; CESC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg03709012 chr19:19516395 GATAD2A 1.0 15.73 0.69 7.65e-40 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12073537 chr12:49658926 TUBA1C -0.59 -6.09 -0.35 3.97e-9 Gut microbiome composition (summer); CESC cis rs4803468 1.000 rs284650 chr19:41927129 A/G cg14132834 chr19:41945861 ATP5SL -0.67 -8.35 -0.46 3.74e-15 Height; CESC cis rs9549260 0.755 rs9532577 chr13:41231542 A/G cg21288729 chr13:41239152 FOXO1 0.66 8.57 0.47 8.94e-16 Red blood cell count; CESC cis rs6460942 0.908 rs117451929 chr7:12265149 A/T cg06484146 chr7:12443880 VWDE -0.61 -6.34 -0.36 9.59e-10 Coronary artery disease; CESC cis rs765787 0.530 rs7167389 chr15:45535683 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.11 -0.4 1.08e-11 Uric acid levels; CESC cis rs34779708 0.733 rs7914468 chr10:35548071 G/A cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs710865 0.527 rs2275403 chr1:19557713 C/G cg13387374 chr1:19411106 UBR4 -0.81 -12.36 -0.6 5.24e-28 Brain structure; CESC cis rs2243480 1.000 rs1546059 chr7:65654709 C/A cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.24e-32 Diabetic kidney disease; CESC cis rs12155623 1.000 rs12155623 chr8:49812201 A/T cg22283653 chr8:49824208 NA -0.35 -5.5 -0.32 8.85e-8 Sudden cardiac arrest; CESC cis rs588177 0.613 rs3782101 chr11:64131280 A/G cg24431193 chr11:63883947 FLRT1;MACROD1 0.42 6.06 0.35 4.59e-9 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs7618501 1.000 rs35261599 chr3:49773236 G/A cg21659725 chr3:3221576 CRBN -0.83 -13.69 -0.64 1.24e-32 Intelligence (multi-trait analysis); CESC cis rs7250872 0.647 rs2304612 chr19:1817866 A/G cg10370574 chr19:1840461 REXO1 0.45 6.32 0.36 1.09e-9 Bipolar disorder; CESC cis rs3780486 0.834 rs75443249 chr9:33149207 A/G cg13443165 chr9:33130375 B4GALT1 0.41 5.48 0.32 9.86e-8 IgG glycosylation; CESC cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg16743903 chr16:89593216 SPG7 0.55 6.9 0.39 3.76e-11 Multiple myeloma (IgH translocation); CESC cis rs1062177 0.756 rs2964591 chr5:151117397 A/G cg00977110 chr5:151150581 G3BP1 -0.58 -6.16 -0.35 2.67e-9 Preschool internalizing problems; CESC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg23758822 chr17:41437982 NA 1.02 15.8 0.7 4.51e-40 Menopause (age at onset); CESC cis rs1707322 1.000 rs785478 chr1:46491635 C/T cg05343316 chr1:45956843 TESK2 -0.45 -5.57 -0.32 6.17e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3796619 1.000 rs13146371 chr4:1082887 C/T cg27284194 chr4:1044797 NA 0.37 5.51 0.32 8.48e-8 Recombination rate (males); CESC cis rs10883723 0.737 rs7074444 chr10:104249922 A/G cg22532475 chr10:104410764 TRIM8 -0.33 -5.67 -0.33 3.67e-8 Allergic disease (asthma, hay fever or eczema); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03115081 chr17:74722049 C17orf95;JMJD6 0.49 6.8 0.39 7.06e-11 Systemic lupus erythematosus; CESC cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg05283184 chr6:79620031 NA -0.43 -6.5 -0.37 3.94e-10 Intelligence (multi-trait analysis); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg21647170 chr7:56119546 CCT6A;PSPH 0.47 6.19 0.36 2.32e-9 Systemic lupus erythematosus; CESC cis rs2832191 0.716 rs9983051 chr21:30371890 C/T cg24692254 chr21:30365293 RNF160 1.02 18.47 0.75 1.56e-49 Dental caries; CESC cis rs950776 0.593 rs621849 chr15:78872861 G/A cg06917634 chr15:78832804 PSMA4 -0.6 -8.04 -0.44 2.96e-14 Sudden cardiac arrest; CESC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg09877947 chr5:131593287 PDLIM4 0.48 6.24 0.36 1.7e-9 Breast cancer; CESC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg03609598 chr5:56110824 MAP3K1 -0.51 -5.42 -0.32 1.36e-7 Type 2 diabetes; CESC cis rs7223966 0.921 rs2727300 chr17:61965398 G/A cg11494091 chr17:61959527 GH2 0.42 5.66 0.33 3.9e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs10465746 0.967 rs11163876 chr1:84440605 T/C cg10977910 chr1:84465055 TTLL7 0.47 6.43 0.37 6.02e-10 Obesity-related traits; CESC cis rs1005277 0.589 rs2749624 chr10:38529865 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -5.68 -0.33 3.45e-8 Extrinsic epigenetic age acceleration; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20011543 chr20:42086465 SFRS6 -0.51 -6.48 -0.37 4.5e-10 Asthma; CESC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.83 -0.34 1.62e-8 Total body bone mineral density; CESC cis rs4835473 0.932 rs13134327 chr4:144659795 A/G cg25736465 chr4:144833511 NA 0.32 5.04 0.3 8.45e-7 Immature fraction of reticulocytes; CESC cis rs2294693 0.947 rs9381025 chr6:40986623 C/T cg14769373 chr6:40998127 UNC5CL -0.41 -5.95 -0.34 8.64e-9 Gastric cancer;Non-cardia gastric cancer; CESC cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7617773 0.817 rs9819094 chr3:48319558 C/T cg11946769 chr3:48343235 NME6 0.76 9.85 0.52 1.05e-19 Coronary artery disease; CESC cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg18904891 chr8:8559673 CLDN23 0.73 8.12 0.45 1.74e-14 Obesity-related traits; CESC cis rs9611565 0.625 rs12483991 chr22:41935285 A/G cg03806693 chr22:41940476 POLR3H -0.91 -11.39 -0.57 1e-24 Vitiligo; CESC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs921968 0.519 rs62191659 chr2:219630510 C/T cg02176678 chr2:219576539 TTLL4 -0.44 -7.71 -0.43 2.56e-13 Mean corpuscular hemoglobin concentration; CESC cis rs11098499 0.863 rs34308924 chr4:120481431 T/C cg24375607 chr4:120327624 NA 0.45 5.51 0.32 8.55e-8 Corneal astigmatism; CESC cis rs9308731 0.591 rs7588534 chr2:111945087 T/C cg04202892 chr2:111875749 ACOXL 0.37 5.17 0.3 4.61e-7 Chronic lymphocytic leukemia; CESC trans rs7937682 0.824 rs539524 chr11:111477325 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.17 0.35 2.61e-9 Primary sclerosing cholangitis; CESC cis rs4660306 0.961 rs2152077 chr1:45986670 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.52 -6.68 -0.38 1.41e-10 Homocysteine levels; CESC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg07648498 chr16:89883185 FANCA 0.43 5.39 0.31 1.57e-7 Vitiligo; CESC cis rs922182 0.569 rs6494457 chr15:64263532 C/A cg24729988 chr15:64271149 DAPK2 0.4 5.32 0.31 2.21e-7 Blood protein levels; CESC cis rs2795502 1.000 rs1581702 chr10:43344246 G/A cg27426351 chr10:43362370 NA 0.48 6.05 0.35 4.79e-9 Blood protein levels; CESC cis rs9291683 0.527 rs3822247 chr4:10094671 G/A cg05927159 chr4:10118984 WDR1 0.36 5.39 0.31 1.54e-7 Bone mineral density; CESC cis rs7726839 0.526 rs11960158 chr5:568665 C/T cg16447950 chr5:562315 NA -0.67 -7.91 -0.44 6.9e-14 Obesity-related traits; CESC trans rs877282 1.000 rs112522746 chr10:772288 T/C cg22713356 chr15:30763199 NA 1.15 11.76 0.59 5.59e-26 Uric acid levels; CESC cis rs34375054 0.525 rs7136220 chr12:125602684 T/C cg25124228 chr12:125621409 AACS -0.57 -7.12 -0.4 1.01e-11 Post bronchodilator FEV1/FVC ratio; CESC cis rs34779708 0.966 rs12762493 chr10:35471873 G/A cg03585969 chr10:35415529 CREM 0.77 10.23 0.53 6.59e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs2180341 1.000 rs3798852 chr6:127636733 A/G cg27446573 chr6:127587934 RNF146 1.09 16.38 0.71 3.79e-42 Breast cancer; CESC cis rs7666738 0.830 rs62318503 chr4:98935479 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7927592 0.731 rs11228288 chr11:68353550 A/G cg16797656 chr11:68205561 LRP5 0.48 7.13 0.4 9.41e-12 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17274881 chr4:79103244 FRAS1 -0.63 -7.68 -0.43 3.09e-13 Gut microbiome composition (summer); CESC cis rs2718058 0.519 rs2722233 chr7:37875982 A/T cg15028436 chr7:37888078 TXNDC3 0.42 6.37 0.36 8.15e-10 Alzheimer's disease (late onset); CESC cis rs2228479 0.850 rs76075456 chr16:89834270 T/C cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.86 0.43 9.54e-14 Prudent dietary pattern; CESC cis rs2637266 0.783 rs846585 chr10:78494466 T/G cg18941641 chr10:78392320 NA 0.44 8.57 0.47 8.52e-16 Pulmonary function; CESC cis rs7914558 1.000 rs10748838 chr10:104943986 T/A cg04362960 chr10:104952993 NT5C2 0.46 6.16 0.35 2.74e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs614226 1.000 rs1167725 chr12:120968559 A/T cg01236616 chr12:121019343 POP5 1.55 19.98 0.78 8.29e-55 Type 1 diabetes nephropathy; CESC cis rs4919087 0.748 rs1687369 chr10:98976923 G/A cg25902810 chr10:99078978 FRAT1 -0.51 -5.72 -0.33 2.82e-8 Monocyte count; CESC cis rs631288 0.557 rs894470 chr1:146671947 A/G cg25205988 chr1:146714368 CHD1L 1.05 6.7 0.38 1.23e-10 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs8114671 0.562 rs6088621 chr20:33418740 C/T cg08999081 chr20:33150536 PIGU 0.39 5.49 0.32 9.56e-8 Height; CESC cis rs4481887 0.741 rs6674078 chr1:248543026 G/A cg26353448 chr1:248524236 OR2T4 -0.37 -5.12 -0.3 5.85e-7 Common traits (Other); CESC cis rs2070677 0.799 rs11101854 chr10:135394430 G/A cg20169779 chr10:135381914 SYCE1 -0.76 -10.08 -0.53 1.91e-20 Gout; CESC cis rs1801251 1.000 rs895430 chr2:233725483 C/A cg25237894 chr2:233734115 C2orf82 -0.48 -8.29 -0.45 5.74e-15 Coronary artery disease; CESC cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg05973401 chr12:123451056 ABCB9 -0.44 -5.19 -0.3 4.26e-7 Height;Educational attainment;Head circumference (infant); CESC cis rs12497850 0.865 rs7649458 chr3:48920127 C/T cg07636037 chr3:49044803 WDR6 1.02 19.51 0.77 3.76e-53 Parkinson's disease; CESC cis rs11190604 1.000 rs1106565 chr10:102211613 T/C cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs3747547 0.792 rs11790106 chr9:38047710 G/A cg13774184 chr9:37916125 SHB -0.71 -5.6 -0.33 5.44e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg23649088 chr2:200775458 C2orf69 -0.77 -10.07 -0.53 2.05e-20 Osteoporosis; CESC cis rs12497850 0.931 rs4974085 chr3:48924900 C/T cg07636037 chr3:49044803 WDR6 0.99 18.75 0.76 1.69e-50 Parkinson's disease; CESC cis rs2281845 0.507 rs10800760 chr1:201100439 G/A cg06714761 chr1:201096289 NA 0.44 6.83 0.39 5.8200000000000003e-11 Permanent tooth development; CESC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg12034118 chr1:209979487 IRF6 0.44 5.4 0.32 1.46e-7 Cleft lip with or without cleft palate; CESC cis rs7851660 0.874 rs10120412 chr9:100628238 T/C cg13688889 chr9:100608707 NA -0.63 -8.87 -0.48 1.09e-16 Strep throat; CESC cis rs6598955 0.666 rs12759434 chr1:26607123 C/T cg04990556 chr1:26633338 UBXN11 -0.79 -11.49 -0.58 4.51e-25 Obesity-related traits; CESC cis rs7826238 0.535 rs2979179 chr8:8320029 C/T cg06636001 chr8:8085503 FLJ10661 0.47 6.3 0.36 1.26e-9 Systolic blood pressure; CESC cis rs208520 0.690 rs12213561 chr6:66705646 T/C cg07460842 chr6:66804631 NA 0.97 13.24 0.63 4.76e-31 Exhaled nitric oxide output; CESC cis rs6089584 0.566 rs55881457 chr20:60608424 G/A cg24733560 chr20:60626293 TAF4 0.48 7.18 0.4 6.85e-12 Body mass index; CESC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg11764359 chr7:65958608 NA -0.8 -8.87 -0.48 1.14e-16 Aortic root size; CESC cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg04455712 chr21:45112962 RRP1B 0.34 5.16 0.3 4.93e-7 Mean corpuscular volume; CESC trans rs35110281 0.626 rs162388 chr21:44936032 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 6.07 0.35 4.34e-9 Mean corpuscular volume; CESC cis rs6424115 0.830 rs2229584 chr1:24200969 T/C cg10978503 chr1:24200527 CNR2 0.33 6.64 0.38 1.73e-10 Immature fraction of reticulocytes; CESC cis rs13191362 0.507 rs2155506 chr6:163035342 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.54 -6.89 -0.39 3.97e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg05343316 chr1:45956843 TESK2 -0.47 -5.9 -0.34 1.1e-8 High light scatter reticulocyte count; CESC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg05332525 chr7:65337924 VKORC1L1 0.51 6.21 0.36 2.01e-9 Calcium levels; CESC cis rs7917772 0.503 rs1409310 chr10:104282265 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.59 0.42 5.46e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg07507251 chr3:52567010 NT5DC2 0.42 7.32 0.41 2.95e-12 Bipolar disorder; CESC cis rs7568458 0.527 rs35416445 chr2:85773659 A/G cg02493740 chr2:85810744 VAMP5 -0.57 -8.33 -0.46 4.41e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs71636778 0.543 rs11810321 chr1:27220521 T/G cg12203394 chr1:27248618 NUDC 0.67 5.43 0.32 1.26e-7 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs9309473 0.898 rs7580750 chr2:73788126 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -6.37 -0.36 8.47e-10 Metabolite levels; CESC cis rs796364 0.806 rs12616905 chr2:201007764 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -6.83 -0.39 5.71e-11 Schizophrenia; CESC cis rs6732160 0.741 rs6546806 chr2:73386160 T/C cg01422370 chr2:73384389 NA 0.43 7.36 0.41 2.38e-12 Intelligence (multi-trait analysis); CESC cis rs6089829 1.000 rs6089828 chr20:61668998 C/T cg08564027 chr20:61660810 NA 0.89 14.86 0.67 9.37e-37 Prostate cancer (SNP x SNP interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22798821 chr11:11864085 USP47 -0.49 -7.02 -0.4 1.91e-11 Gambling; CESC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.8 0.34 1.92e-8 Tonsillectomy; CESC cis rs7772486 0.790 rs2265917 chr6:146212285 A/G cg23711669 chr6:146136114 FBXO30 0.92 13.36 0.63 1.78e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg18180107 chr4:99064573 C4orf37 0.41 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9488822 0.676 rs12202641 chr6:116314634 A/G cg18764771 chr6:116381957 FRK -0.23 -5.84 -0.34 1.51e-8 Cholesterol, total;LDL cholesterol; CESC cis rs12048904 0.595 rs2295280 chr1:101342497 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.48 6.13 0.35 3.17e-9 Multiple sclerosis; CESC cis rs763121 1.000 rs138464 chr22:38906432 C/T cg06544989 chr22:39130855 UNC84B -0.45 -8.16 -0.45 1.37e-14 Menopause (age at onset); CESC cis rs9381040 0.748 rs9357348 chr6:41154232 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -5.21 -0.3 3.83e-7 Alzheimer's disease (late onset); CESC trans rs2207136 0.771 rs2746660 chr6:50878205 A/T cg06522515 chr3:184090630 THPO -0.34 -6.02 -0.35 5.64e-9 Myopia; CESC cis rs1023500 0.596 rs5751204 chr22:42433801 C/T cg15557168 chr22:42548783 NA -0.4 -5.35 -0.31 1.93e-7 Schizophrenia; CESC cis rs2549003 0.933 rs7719499 chr5:131814091 C/G cg21138405 chr5:131827807 IRF1 0.54 8.92 0.48 7.98e-17 Asthma (sex interaction); CESC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg25251562 chr2:3704773 ALLC -0.59 -5.75 -0.33 2.5e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs155076 0.711 rs4770129 chr13:21882059 T/G cg06138931 chr13:21896616 NA 0.51 5.27 0.31 2.8e-7 White matter hyperintensity burden; CESC cis rs796364 0.806 rs203765 chr2:200903020 G/A cg23649088 chr2:200775458 C2orf69 -0.57 -5.24 -0.31 3.23e-7 Schizophrenia; CESC cis rs11123694 1.000 rs11123694 chr2:109064563 C/T cg23706161 chr2:109336669 RANBP2 -0.39 -5.54 -0.32 7.24e-8 Mean platelet volume; CESC cis rs9910055 0.529 rs2523161 chr17:42179405 C/T cg19774624 chr17:42201019 HDAC5 0.62 8.84 0.48 1.33e-16 Total body bone mineral density; CESC cis rs9888739 0.800 rs11859300 chr16:31355895 G/T cg15817542 chr16:31343056 ITGAM -0.53 -7.61 -0.42 4.83e-13 Systemic lupus erythematosus; CESC cis rs7560272 0.723 rs7562047 chr2:73725168 G/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.83 -0.39 5.8e-11 Schizophrenia; CESC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg13798912 chr7:905769 UNC84A 0.56 5.7 0.33 3.11e-8 Cerebrospinal P-tau181p levels; CESC cis rs9291683 0.530 rs6449196 chr4:9973660 C/T cg11266682 chr4:10021025 SLC2A9 -0.61 -12.55 -0.61 1.13e-28 Bone mineral density; CESC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg22963979 chr7:1858916 MAD1L1 -0.43 -5.95 -0.34 8.59e-9 Bipolar disorder and schizophrenia; CESC cis rs17826219 0.706 rs9893922 chr17:29068425 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Body mass index; CESC cis rs6430585 0.697 rs115944351 chr2:136515458 G/A cg07169764 chr2:136633963 MCM6 1.27 16.82 0.72 1.04e-43 Corneal structure; CESC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.34 0.81 6.93e-63 Prudent dietary pattern; CESC cis rs477692 0.905 rs485579 chr10:131425492 T/G cg26102564 chr10:131424627 MGMT 0.36 5.39 0.31 1.52e-7 Response to temozolomide; CESC cis rs8014204 0.967 rs2359240 chr14:75328247 T/C cg11812906 chr14:75593930 NEK9 -0.41 -5.08 -0.3 7.16e-7 Caffeine consumption; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02480931 chr1:228270396 ARF1 0.62 6.63 0.38 1.86e-10 Gut microbiome composition (summer); CESC cis rs524023 0.874 rs519090 chr11:64456240 G/C cg07220939 chr11:64358617 SLC22A12 -0.35 -5.42 -0.32 1.36e-7 Urate levels in obese individuals; CESC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg11494091 chr17:61959527 GH2 0.37 5.12 0.3 5.97e-7 Height; CESC cis rs3812762 0.868 rs7952335 chr11:8754031 A/G cg03980550 chr11:8754370 ST5 0.36 5.19 0.3 4.17e-7 Hypospadias; CESC cis rs854765 0.693 rs8079321 chr17:17760789 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.44 5.87 0.34 1.28e-8 Total body bone mineral density; CESC cis rs6963495 0.818 rs56177071 chr7:105165648 C/T cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs5769765 1.000 rs5769765 chr22:50271176 G/A cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21173440 chr5:55008212 SLC38A9 0.61 7.38 0.41 2.08e-12 Gut microbiome composition (summer); CESC trans rs11098499 0.754 rs1980026 chr4:120251643 C/A cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs1355223 0.902 rs34610590 chr11:34725440 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.24 -0.36 1.68e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.53 -0.37 3.44e-10 Intelligence (multi-trait analysis); CESC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg06028808 chr11:68637592 NA 0.49 5.74 0.33 2.6e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg23838308 chr17:57785056 PTRH2;TMEM49 0.49 6.38 0.36 7.79e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs2629540 0.508 rs12217633 chr10:126533872 A/G cg08799069 chr10:126477246 METTL10 -0.52 -6.34 -0.36 9.63e-10 Cocaine dependence; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22141780 chr2:132233726 TUBA3D 0.45 6.0 0.35 6.33e-9 Fibrinogen levels; CESC cis rs6120849 0.754 rs13433216 chr20:33616301 T/C cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs1348850 0.519 rs1544002 chr2:178529534 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 7.06 0.4 1.5e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3820928 0.839 rs13398103 chr2:227859693 T/G cg11843606 chr2:227700838 RHBDD1 -0.5 -6.03 -0.35 5.52e-9 Pulmonary function; CESC cis rs7918232 0.891 rs10443987 chr10:27375377 A/T cg14442939 chr10:27389572 ANKRD26 0.7 6.5 0.37 4.04e-10 Breast cancer; CESC trans rs208515 0.525 rs9453538 chr6:66668508 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 10.74 0.55 1.42e-22 Exhaled nitric oxide levels; CESC cis rs7666738 0.830 rs9998682 chr4:98939009 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6088580 0.505 rs6058106 chr20:33278255 T/C cg08999081 chr20:33150536 PIGU -0.45 -6.52 -0.37 3.51e-10 Glomerular filtration rate (creatinine); CESC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg05564831 chr3:52568323 NT5DC2 0.43 6.24 0.36 1.71e-9 Bipolar disorder; CESC cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.4 0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg13906792 chr15:75199810 C15orf17 -0.34 -5.18 -0.3 4.47e-7 Breast cancer; CESC cis rs9457247 0.967 rs1211447 chr6:167381979 C/T cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.27e-8 Crohn's disease; CESC cis rs3749237 0.595 rs12489092 chr3:49550914 G/C cg07636037 chr3:49044803 WDR6 0.63 9.27 0.49 6.73e-18 Resting heart rate; CESC cis rs8180040 0.654 rs62246451 chr3:47211632 C/T cg27129171 chr3:47204927 SETD2 -0.67 -9.83 -0.52 1.2e-19 Colorectal cancer; CESC cis rs9914988 0.725 rs66531973 chr17:27125993 G/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg09177884 chr7:1199841 ZFAND2A -0.55 -7.31 -0.41 3.16e-12 Longevity;Endometriosis; CESC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg19163074 chr7:65112434 INTS4L2 0.42 5.28 0.31 2.63e-7 Aortic root size; CESC trans rs10506458 1.000 rs73128779 chr12:63441852 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.32 -17.48 -0.73 4.95e-46 Hemostatic factors and hematological phenotypes; CESC cis rs10504073 0.647 rs62507246 chr8:50013449 G/A cg00325661 chr8:49890786 NA 0.57 8.6 0.47 7.15e-16 Blood metabolite ratios; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04691540 chr1:179198414 ABL2 -0.47 -6.99 -0.39 2.23e-11 Gambling; CESC cis rs13191362 0.507 rs2155506 chr6:163035342 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.5 -6.24 -0.36 1.74e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg25427524 chr10:38739819 LOC399744 -0.66 -9.52 -0.5 1.15e-18 Extrinsic epigenetic age acceleration; CESC cis rs763121 0.853 rs2413545 chr22:39092524 C/T cg14440974 chr22:39074834 NA -0.43 -5.63 -0.33 4.49e-8 Menopause (age at onset); CESC cis rs7904368 0.901 rs7923189 chr10:16850214 C/T cg23933602 chr10:16859644 RSU1 0.74 8.23 0.45 8.48e-15 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs854765 0.583 rs7214536 chr17:17852446 G/A cg04398451 chr17:18023971 MYO15A -0.69 -9.72 -0.51 2.77e-19 Total body bone mineral density; CESC cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.64 8.08 0.44 2.36e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs12325245 0.536 rs34161389 chr16:58622604 G/A cg01152986 chr16:58549298 SETD6 0.86 5.07 0.3 7.48e-7 Schizophrenia; CESC cis rs6942756 0.680 rs691555 chr7:129135770 C/T cg02491457 chr7:128862824 NA -0.54 -7.68 -0.43 3e-13 White matter hyperintensity burden; CESC cis rs9325144 0.555 rs2387855 chr12:38687964 T/G cg26384229 chr12:38710491 ALG10B 0.58 8.59 0.47 7.74e-16 Morning vs. evening chronotype; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24598330 chr12:95467350 NR2C1 0.48 6.06 0.35 4.71e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.840 rs4822025 chr22:41776646 C/G cg03806693 chr22:41940476 POLR3H -1.11 -13.72 -0.64 1.03e-32 Vitiligo; CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 7.58 0.42 5.94e-13 Bipolar disorder; CESC cis rs909674 0.775 rs4821896 chr22:39833437 T/C cg24399712 chr22:39784796 NA -0.8 -10.86 -0.55 5.8e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg07677032 chr17:61819896 STRADA -0.47 -6.25 -0.36 1.67e-9 Prudent dietary pattern; CESC cis rs10504229 0.906 rs2270608 chr8:58194688 T/C cg05313129 chr8:58192883 C8orf71 -0.53 -6.07 -0.35 4.46e-9 Developmental language disorder (linguistic errors); CESC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg14926445 chr8:58193284 C8orf71 -0.49 -5.54 -0.32 7.13e-8 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg19592336 chr6:28129416 ZNF389 0.61 8.17 0.45 1.28e-14 Depression; CESC cis rs5769765 0.908 rs9627788 chr22:50300438 T/C cg02269571 chr22:50332266 NA -0.49 -6.59 -0.38 2.43e-10 Schizophrenia; CESC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg11890956 chr21:40555474 PSMG1 -0.97 -16.62 -0.71 5.65e-43 Cognitive function; CESC cis rs9527 0.830 rs10883790 chr10:104640955 A/C cg04362960 chr10:104952993 NT5C2 0.45 5.28 0.31 2.69e-7 Arsenic metabolism; CESC cis rs1707322 1.000 rs10890376 chr1:46406582 C/T cg06784218 chr1:46089804 CCDC17 0.36 6.01 0.35 5.95e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7615952 0.515 rs4441610 chr3:125681307 C/G cg05084668 chr3:125655381 ALG1L -0.48 -5.62 -0.33 4.93e-8 Blood pressure (smoking interaction); CESC cis rs4835473 0.900 rs13105550 chr4:144655373 C/T cg25736465 chr4:144833511 NA -0.32 -5.04 -0.3 8.48e-7 Immature fraction of reticulocytes; CESC cis rs2832191 0.755 rs2832192 chr21:30491173 G/T cg24692254 chr21:30365293 RNF160 -0.7 -9.97 -0.52 4.44e-20 Dental caries; CESC cis rs7520050 0.807 rs4274104 chr1:46217941 T/C cg06784218 chr1:46089804 CCDC17 0.32 5.84 0.34 1.55e-8 Red blood cell count;Reticulocyte count; CESC cis rs2243480 0.901 rs35256305 chr7:65306405 T/C cg12463550 chr7:65579703 CRCP 0.68 5.73 0.33 2.72e-8 Diabetic kidney disease; CESC cis rs9303401 0.614 rs3803753 chr17:56540110 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.98 11.87 0.59 2.46e-26 Cognitive test performance; CESC cis rs7666738 0.830 rs7659420 chr4:98878714 G/C cg03467027 chr4:99064603 C4orf37 0.43 5.3 0.31 2.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg05564831 chr3:52568323 NT5DC2 0.48 7.68 0.43 3.01e-13 Electroencephalogram traits; CESC cis rs6831352 1.000 rs6822348 chr4:100053894 A/T cg12011299 chr4:100065546 ADH4 0.7 8.56 0.47 9.45e-16 Alcohol dependence; CESC cis rs113835537 0.935 rs79106199 chr11:66420518 T/C cg24851651 chr11:66362959 CCS 0.63 5.68 0.33 3.48e-8 Airway imaging phenotypes; CESC cis rs477692 0.569 rs1711670 chr10:131281115 A/G cg05714579 chr10:131428358 MGMT 0.39 5.13 0.3 5.63e-7 Response to temozolomide; CESC cis rs2228479 0.850 rs17226428 chr16:89842884 T/A cg06558623 chr16:89946397 TCF25 1.17 9.33 0.5 4.35e-18 Skin colour saturation; CESC cis rs10883723 0.810 rs913025 chr10:104276043 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.41 0.41 1.65e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs78456975 0.657 rs116217838 chr2:1569173 T/C cg26248373 chr2:1572462 NA -0.6 -6.99 -0.39 2.18e-11 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9457247 0.588 rs35171809 chr6:167432766 A/G cg25258033 chr6:167368657 RNASET2 0.35 5.13 0.3 5.7e-7 Crohn's disease; CESC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg05255149 chr17:80675120 FN3KRP -0.46 -5.3 -0.31 2.43e-7 Breast cancer; CESC cis rs7590368 0.673 rs17365216 chr2:10939241 A/G cg15705551 chr2:10952987 PDIA6 0.54 5.23 0.31 3.48e-7 Educational attainment (years of education); CESC cis rs453301 0.658 rs6986044 chr8:8874786 G/C cg15556689 chr8:8085844 FLJ10661 -0.47 -5.71 -0.33 3.03e-8 Joint mobility (Beighton score); CESC trans rs9929218 1.000 rs13334294 chr16:68809278 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -8.03 -0.44 3.1e-14 Colorectal cancer; CESC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg09913183 chr17:42254507 C17orf65;ASB16 0.65 8.59 0.47 7.54e-16 Total body bone mineral density; CESC cis rs2455799 0.613 rs13080145 chr3:15880060 C/G cg16303742 chr3:15540471 COLQ -0.37 -5.74 -0.33 2.59e-8 Mean platelet volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06419771 chr15:42264912 EHD4 0.49 6.29 0.36 1.32e-9 Gut microbiota (bacterial taxa); CESC cis rs57506017 0.585 rs1468801 chr7:12276045 G/C cg23422036 chr7:12250390 TMEM106B 0.39 5.24 0.31 3.35e-7 Neuroticism; CESC cis rs34375054 0.558 rs67041765 chr12:125672913 T/G cg00522288 chr12:125625016 AACS -0.36 -5.65 -0.33 4.05e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs2880765 0.835 rs4344688 chr15:86043007 A/C cg19183879 chr15:85880815 NA -0.26 -5.38 -0.31 1.67e-7 Coronary artery disease; CESC cis rs6088580 0.634 rs1205345 chr20:32914699 A/G cg06115741 chr20:33292138 TP53INP2 -0.43 -5.51 -0.32 8.33e-8 Glomerular filtration rate (creatinine); CESC cis rs7914558 1.000 rs4917994 chr10:104811699 C/T cg04362960 chr10:104952993 NT5C2 0.47 6.32 0.36 1.11e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs10905065 0.895 rs1567706 chr10:5853767 T/C cg11519256 chr10:5708881 ASB13 -0.4 -5.21 -0.3 3.87e-7 Menopause (age at onset); CESC cis rs2228479 0.618 rs72477006 chr16:89950299 G/C cg14709524 chr16:89940631 TCF25 0.73 5.55 0.32 6.81e-8 Skin colour saturation; CESC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg15145296 chr3:125709740 NA -0.56 -5.91 -0.34 1.06e-8 Blood pressure (smoking interaction); CESC cis rs2290720 0.930 rs11110742 chr12:101692559 G/A cg22051763 chr12:101673672 UTP20 -0.48 -6.0 -0.35 6.43e-9 Brain structure (hippocampal volume); CESC cis rs2250402 0.510 rs2291621 chr15:40324837 C/T cg01081584 chr15:40268610 EIF2AK4 -0.54 -5.05 -0.3 8.23e-7 Corneal curvature; CESC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg04267008 chr7:1944627 MAD1L1 0.53 6.51 0.37 3.79e-10 Bipolar disorder and schizophrenia; CESC cis rs763121 0.752 rs5757222 chr22:39060473 C/T cg14440974 chr22:39074834 NA -0.4 -5.5 -0.32 9.03e-8 Menopause (age at onset); CESC cis rs9815354 0.680 rs73073292 chr3:42028023 C/A cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs7527798 0.592 rs10863437 chr1:207817612 T/C cg21110645 chr1:207815933 NA -0.31 -5.38 -0.31 1.64e-7 Erythrocyte sedimentation rate; CESC cis rs2070677 0.501 rs2274665 chr10:135295630 T/C cg20169779 chr10:135381914 SYCE1 0.41 5.39 0.31 1.54e-7 Gout; CESC cis rs227584 0.663 rs2040810 chr17:42243771 C/T cg08499158 chr17:42289980 UBTF 0.43 5.47 0.32 1.05e-7 Bone mineral density (hip);Bone mineral density; CESC cis rs9549260 0.755 rs9532579 chr13:41243458 T/C cg21288729 chr13:41239152 FOXO1 0.67 8.59 0.47 7.42e-16 Red blood cell count; CESC cis rs7592578 0.723 rs4371384 chr2:191430741 A/G cg10560079 chr2:191398806 TMEM194B 0.67 5.98 0.34 7.17e-9 Diastolic blood pressure; CESC cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg05347473 chr6:146136440 FBXO30 0.75 9.51 0.5 1.19e-18 Lobe attachment (rater-scored or self-reported); CESC cis rs13064411 0.696 rs9869318 chr3:113146271 T/C cg18753928 chr3:113234510 CCDC52 -0.49 -5.34 -0.31 2.04e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09800975 chr10:6130861 RBM17 -0.6 -6.69 -0.38 1.32e-10 Gut microbiome composition (summer); CESC cis rs12464559 0.522 rs7424335 chr2:152593741 C/T cg01189475 chr2:152685088 ARL5A 0.65 6.32 0.36 1.09e-9 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg11764359 chr7:65958608 NA 0.96 15.23 0.68 4.78e-38 Aortic root size; CESC cis rs17601876 0.814 rs8038715 chr15:51561120 T/A cg19946085 chr15:51559439 CYP19A1 -0.32 -5.06 -0.3 7.7e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg21144161 chr5:423903 AHRR 0.37 5.98 0.34 7.12e-9 Cystic fibrosis severity; CESC cis rs4423214 0.840 rs1792231 chr11:71182681 G/A cg05163923 chr11:71159392 DHCR7 -0.68 -7.76 -0.43 1.82e-13 Vitamin D levels; CESC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg12463550 chr7:65579703 CRCP -0.55 -7.0 -0.39 2.15e-11 Aortic root size; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg05215748 chr17:6898738 ALOX12 -0.29 -5.95 -0.34 8.35e-9 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18950102 chr11:33397689 NA 0.57 6.78 0.38 7.95e-11 Gut microbiome composition (summer); CESC cis rs7640424 0.819 rs34154497 chr3:107824222 T/C cg09227934 chr3:107805635 CD47 -0.5 -6.23 -0.36 1.82e-9 Body mass index; CESC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg05896524 chr21:47604654 C21orf56 0.41 5.32 0.31 2.17e-7 Testicular germ cell tumor; CESC trans rs11989744 0.597 rs11135768 chr8:23573278 A/G cg03492747 chr16:86543808 FOXF1 0.83 12.66 0.61 4.64e-29 Waist-hip ratio; CESC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg09177884 chr7:1199841 ZFAND2A -0.42 -5.22 -0.31 3.7e-7 Longevity;Endometriosis; CESC cis rs2075371 0.829 rs11770521 chr7:133936251 A/C cg11752832 chr7:134001865 SLC35B4 0.53 6.85 0.39 5.07e-11 Mean platelet volume; CESC cis rs7618501 1.000 rs4855867 chr3:49745822 C/T cg24308560 chr3:49941425 MST1R 0.5 6.94 0.39 3.08e-11 Intelligence (multi-trait analysis); CESC trans rs11088226 0.681 rs2833926 chr21:33975279 A/G cg09050820 chr6:167586206 TCP10L2 0.76 8.03 0.44 3.2e-14 Gastritis; CESC cis rs7107174 1.000 rs10899452 chr11:77995143 A/C cg02023728 chr11:77925099 USP35 0.42 5.54 0.32 7.12e-8 Testicular germ cell tumor; CESC cis rs10256972 0.900 rs4388364 chr7:1033045 T/G cg04025307 chr7:1156635 C7orf50 0.39 6.19 0.36 2.32e-9 Longevity;Endometriosis; CESC cis rs11792861 0.816 rs7021366 chr9:111727670 C/G cg05043794 chr9:111880884 C9orf5 -0.4 -6.59 -0.38 2.33e-10 Menarche (age at onset); CESC cis rs9399137 0.507 rs4451150 chr6:135279063 T/G cg22676075 chr6:135203613 NA 0.56 7.24 0.41 4.99e-12 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs4944092 0.960 rs10400322 chr11:75910913 C/T cg04588336 chr11:75916460 WNT11 0.5 7.83 0.43 1.16e-13 PR interval; CESC cis rs2797160 1.000 rs1739371 chr6:126011291 G/A cg05901451 chr6:126070800 HEY2 0.46 6.69 0.38 1.33e-10 Endometrial cancer; CESC cis rs854765 0.693 rs12941039 chr17:17765655 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.47 -6.17 -0.35 2.59e-9 Total body bone mineral density; CESC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg01416388 chr22:39784598 NA 0.57 7.18 0.4 7.01e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg26597838 chr10:835615 NA 0.65 5.82 0.34 1.71e-8 Eosinophil percentage of granulocytes; CESC cis rs8070740 0.898 rs4442872 chr17:5324236 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.28 0.36 1.35e-9 Menopause (age at onset); CESC cis rs7605827 0.930 rs1990755 chr2:15616013 C/G cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs2439831 0.850 rs3759790 chr15:44121030 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.46 0.42 1.21e-12 Lung cancer in ever smokers; CESC cis rs7089973 0.668 rs61868024 chr10:116637939 A/G cg23260525 chr10:116636907 FAM160B1 0.37 6.55 0.37 2.92e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg11890956 chr21:40555474 PSMG1 -0.63 -8.74 -0.47 2.78e-16 Menarche (age at onset); CESC trans rs1493916 1.000 rs9964702 chr18:31390427 A/C cg27147174 chr7:100797783 AP1S1 -0.52 -7.04 -0.4 1.62e-11 Life satisfaction; CESC cis rs6987853 0.933 rs2923424 chr8:42382222 A/G cg09913449 chr8:42400586 C8orf40 -0.4 -6.36 -0.36 9.04e-10 Mean corpuscular hemoglobin concentration; CESC cis rs763014 0.966 rs7198877 chr16:661439 A/G cg07256732 chr16:621771 PIGQ -0.32 -5.55 -0.32 6.94e-8 Height; CESC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg09177884 chr7:1199841 ZFAND2A -0.58 -6.41 -0.37 6.65e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06692641 chr19:40030326 EID2 0.54 6.09 0.35 3.88e-9 Gut microbiome composition (summer); CESC cis rs936229 0.668 rs67411922 chr15:75187612 A/G cg14664628 chr15:75095509 CSK -0.72 -9.02 -0.48 3.93e-17 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs7208859 0.623 rs73269988 chr17:29118145 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs7726839 0.507 rs56282020 chr5:596701 T/C cg25482853 chr8:67687455 SGK3 1.04 10.08 0.53 1.87e-20 Obesity-related traits; CESC cis rs116095464 0.558 rs6555056 chr5:226222 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.78 -0.47 2.06e-16 Breast cancer; CESC cis rs1800469 1.000 rs1549933 chr19:41871142 A/G cg08477640 chr19:41863820 B9D2 0.67 9.24 0.49 8.62e-18 Colorectal cancer; CESC cis rs4835473 0.771 rs2175452 chr4:144914040 C/G cg25736465 chr4:144833511 NA 0.43 6.44 0.37 5.61e-10 Immature fraction of reticulocytes; CESC cis rs4604732 0.603 rs10802513 chr1:247633919 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.58 0.32 6e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12500824 0.506 rs11935098 chr4:77301687 T/C cg20311846 chr4:77356250 SHROOM3 0.37 7.24 0.41 4.96e-12 Coronary artery disease; CESC cis rs4481887 0.893 rs6587450 chr1:248480496 T/A cg00666640 chr1:248458726 OR2T12 0.36 5.98 0.34 7.16e-9 Common traits (Other); CESC cis rs1348850 0.914 rs10194648 chr2:178337031 G/A cg22681709 chr2:178499509 PDE11A -0.44 -6.48 -0.37 4.55e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7512552 0.839 rs696616 chr1:150336173 G/A cg15654264 chr1:150340011 RPRD2 0.39 5.12 0.3 5.94e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs910316 1.000 rs175425 chr14:75626131 T/C cg11812906 chr14:75593930 NEK9 -0.87 -14.35 -0.66 5.82e-35 Height; CESC cis rs10751667 0.666 rs10794347 chr11:939863 G/A cg06064525 chr11:970664 AP2A2 -0.5 -10.04 -0.52 2.7e-20 Alzheimer's disease (late onset); CESC cis rs17023223 0.537 rs12064137 chr1:119709749 G/A cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26108683 chr11:67250618 AIP -0.52 -6.33 -0.36 1.07e-9 Ulcerative colitis; CESC cis rs9815354 0.638 rs111465678 chr3:41864405 C/A cg03022575 chr3:42003672 ULK4 0.49 5.52 0.32 7.99e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs8078723 1.000 rs56922390 chr17:38157021 C/G cg17467752 chr17:38218738 THRA 0.69 10.55 0.54 5.78e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs2227631 0.505 rs6955537 chr7:100759727 A/G cg18465962 chr7:100767262 NA -0.57 -9.5 -0.5 1.31e-18 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs4253772 0.530 rs11090875 chr22:46785301 C/T cg18190219 chr22:46762943 CELSR1 -0.72 -6.66 -0.38 1.62e-10 LDL cholesterol;Cholesterol, total; CESC cis rs910316 0.687 rs175059 chr14:75490667 T/C cg11812906 chr14:75593930 NEK9 -0.82 -13.6 -0.64 2.7e-32 Height; CESC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg18904891 chr8:8559673 CLDN23 0.73 8.41 0.46 2.59e-15 Obesity-related traits; CESC trans rs8073060 0.586 rs7214250 chr17:33981704 C/G cg19694781 chr19:47549865 TMEM160 -0.73 -7.32 -0.41 3.05e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs9584850 0.834 rs2031239 chr13:99111560 C/T cg20750642 chr13:99100586 FARP1 -0.38 -5.74 -0.33 2.6e-8 Neuroticism; CESC cis rs78456975 0.607 rs72776258 chr2:1530732 C/G cg01028140 chr2:1542097 TPO -0.59 -5.65 -0.33 4.21e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs11997175 0.846 rs34860600 chr8:33761566 C/A ch.8.33884649F chr8:33765107 NA 0.78 10.38 0.54 2.15e-21 Body mass index; CESC cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 12.78 0.62 1.78e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21659725 chr3:3221576 CRBN 0.82 13.21 0.63 5.99e-31 Intelligence (multi-trait analysis); CESC cis rs9457247 0.967 rs2015864 chr6:167381476 T/C cg23791538 chr6:167370224 RNASET2 0.6 8.64 0.47 5.52e-16 Crohn's disease; CESC cis rs2072732 0.861 rs12039132 chr1:2949355 C/T cg03976712 chr1:2946727 NA 0.34 5.63 0.33 4.53e-8 Plateletcrit; CESC cis rs3540 0.512 rs3862433 chr15:91076028 G/A cg10434728 chr15:90938212 IQGAP1 -0.39 -7.05 -0.4 1.59e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs796364 0.715 rs1106399 chr2:201003837 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -6.43 -0.37 5.87e-10 Schizophrenia; CESC cis rs362272 0.545 rs3129308 chr4:3309272 C/T cg08886695 chr4:3369023 RGS12 -0.47 -6.34 -0.36 1e-9 Serum sulfate level; CESC cis rs4474465 0.850 rs10899552 chr11:78262262 G/A cg27205649 chr11:78285834 NARS2 0.4 5.09 0.3 6.82e-7 Alzheimer's disease (survival time); CESC cis rs10751667 1.000 rs10794357 chr11:973374 T/C cg20946044 chr11:1010712 AP2A2 -0.41 -5.4 -0.31 1.48e-7 Alzheimer's disease (late onset); CESC cis rs2880765 0.835 rs7161880 chr15:86018746 C/T cg19183879 chr15:85880815 NA -0.25 -5.22 -0.31 3.69e-7 Coronary artery disease; CESC cis rs1355223 0.545 rs7111695 chr11:34874906 T/G cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.59 -0.38 2.37e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg04025307 chr7:1156635 C7orf50 0.48 7.76 0.43 1.79e-13 Longevity;Endometriosis; CESC cis rs11252926 0.801 rs12358553 chr10:558014 C/T cg08603382 chr10:743973 NA -0.55 -6.96 -0.39 2.71e-11 Psychosis in Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12565215 chr6:21602408 NA 0.54 7.09 0.4 1.19e-11 Fibrinogen levels; CESC cis rs2797160 1.000 rs1832938 chr6:125988964 G/C cg05901451 chr6:126070800 HEY2 -0.45 -6.62 -0.38 1.96e-10 Endometrial cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27050550 chr7:44613552 DDX56 -0.45 -6.04 -0.35 5.08e-9 Fibrinogen levels; CESC cis rs9796 0.689 rs28497404 chr15:41449510 A/C cg12426344 chr15:41135900 SPINT1 -0.24 -5.15 -0.3 4.97e-7 Menopause (age at onset); CESC cis rs12822507 0.868 rs34051318 chr12:12798338 T/C cg09462578 chr12:12878428 APOLD1 -0.44 -5.52 -0.32 8.08e-8 Systemic lupus erythematosus; CESC cis rs6963495 0.818 rs73192115 chr7:105169605 T/A cg13798780 chr7:105162888 PUS7 0.77 7.88 0.44 8.3e-14 Bipolar disorder (body mass index interaction); CESC cis rs75477785 0.590 rs4844935 chr1:210176554 T/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.23 0.36 1.82e-9 Cleft lip with or without cleft palate; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07364676 chr22:29137974 CHEK2;HSCB -0.42 -6.1 -0.35 3.82e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9790314 1.000 rs1382426 chr3:161045933 G/A cg03342759 chr3:160939853 NMD3 -0.47 -6.11 -0.35 3.61e-9 Morning vs. evening chronotype; CESC cis rs4237845 0.513 rs7134797 chr12:58263852 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.51 5.61 0.33 4.96e-8 Intelligence (multi-trait analysis); CESC cis rs644799 0.710 rs12272061 chr11:95524067 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.31 0.57 1.88e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg21214715 chr1:184838445 FAM129A -0.42 -6.16 -0.35 2.62e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6688613 0.694 rs2075946 chr1:166818566 A/G cg07049167 chr1:166818506 POGK 0.54 6.68 0.38 1.37e-10 Refractive astigmatism; CESC cis rs8017423 0.967 rs11159956 chr14:90715890 C/T cg14092571 chr14:90743983 NA 0.59 8.87 0.48 1.14e-16 Mortality in heart failure; CESC cis rs14403 0.521 rs3006916 chr1:243639859 A/G cg21452805 chr1:244014465 NA 0.51 5.28 0.31 2.72e-7 Schizophrenia; CESC cis rs881375 0.678 rs1930782 chr9:123687905 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.45 6.47 0.37 4.63e-10 Rheumatoid arthritis; CESC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs17253792 0.749 rs79713967 chr14:56124186 T/C cg01858014 chr14:56050164 KTN1 -0.96 -7.52 -0.42 8.3e-13 Putamen volume; CESC cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4474465 0.790 rs12363982 chr11:78229167 C/T cg27205649 chr11:78285834 NARS2 0.45 5.48 0.32 1e-7 Alzheimer's disease (survival time); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12357364 chr17:1557144 PRPF8 0.45 6.29 0.36 1.32e-9 Fibrinogen levels; CESC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg03264133 chr6:25882463 NA -0.52 -7.28 -0.41 3.8e-12 Intelligence (multi-trait analysis); CESC cis rs4950322 0.515 rs11239958 chr1:146719108 G/A cg16700924 chr1:146552102 NA -0.39 -5.1 -0.3 6.63e-7 Protein quantitative trait loci; CESC cis rs11677416 1.000 rs4848304 chr2:113552737 T/C cg27083787 chr2:113543245 IL1A 0.62 7.7 0.43 2.66e-13 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4746818 0.892 rs10823298 chr10:70867083 T/C cg11621586 chr10:70884670 VPS26A 0.93 9.85 0.52 1.03e-19 Left atrial antero-posterior diameter; CESC cis rs7267979 0.873 rs6037062 chr20:25202892 G/A cg08601574 chr20:25228251 PYGB 0.38 5.47 0.32 1.03e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg05064044 chr6:292385 DUSP22 -0.7 -9.11 -0.49 2.11e-17 Menopause (age at onset); CESC cis rs10089 0.951 rs736969 chr5:127466347 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.22 0.53 6.73e-21 Ileal carcinoids; CESC cis rs4704187 0.601 rs77819698 chr5:74530658 G/T cg03227963 chr5:74354835 NA 0.28 5.17 0.3 4.61e-7 Response to amphetamines; CESC cis rs2249694 1.000 rs2480258 chr10:135352100 T/C cg20169779 chr10:135381914 SYCE1 0.4 5.27 0.31 2.83e-7 Obesity-related traits; CESC trans rs61931739 0.500 rs12832312 chr12:34031199 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.24 0.45 8.06e-15 Morning vs. evening chronotype; CESC cis rs916888 0.821 rs70602 chr17:44859715 T/C cg15921436 chr17:44337874 NA -0.68 -7.54 -0.42 7.6e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4862750 0.872 rs13101380 chr4:187894744 G/A cg07414643 chr4:187882934 NA 0.46 6.55 0.37 2.95e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14454397 chr2:225450036 CUL3 0.57 6.82 0.39 6.1e-11 Gut microbiome composition (summer); CESC cis rs3105593 1.000 rs28494067 chr15:50908272 A/G cg08437265 chr15:50716283 USP8 0.4 5.13 0.3 5.69e-7 QT interval; CESC cis rs9640161 0.830 rs17173682 chr7:150059602 A/G cg21361702 chr7:150065534 REPIN1 0.68 8.52 0.46 1.2e-15 Blood protein levels;Circulating chemerin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14788660 chr1:155278430 FDPS 0.6 7.21 0.4 5.73e-12 Gut microbiome composition (summer); CESC cis rs11577318 0.853 rs12728971 chr1:26626612 C/T cg19743891 chr1:26644573 UBXN11;CD52 -0.28 -5.11 -0.3 6.05e-7 Granulocyte percentage of myeloid white cells; CESC cis rs1376303 0.558 rs12533180 chr7:32944132 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.73 5.58 0.32 5.91e-8 Intelligence (multi-trait analysis); CESC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg09699651 chr6:150184138 LRP11 0.4 5.19 0.3 4.14e-7 Lung cancer; CESC cis rs6912958 0.874 rs9294381 chr6:88152681 A/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -7.48 -0.42 1.08e-12 Monocyte percentage of white cells; CESC cis rs4803468 1.000 rs284656 chr19:41929251 T/C cg14132834 chr19:41945861 ATP5SL -0.66 -8.18 -0.45 1.22e-14 Height; CESC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg18876405 chr7:65276391 NA 0.53 7.28 0.41 3.73e-12 Aortic root size; CESC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg01570182 chr17:44337453 NA 0.63 8.56 0.47 9.17e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7208859 0.623 rs56095789 chr17:29060170 A/G cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg17366294 chr4:99064904 C4orf37 0.56 7.68 0.43 3.1e-13 Colonoscopy-negative controls vs population controls; CESC cis rs6089584 0.546 rs4925337 chr20:60637637 T/C cg24733560 chr20:60626293 TAF4 0.43 6.36 0.36 8.93e-10 Body mass index; CESC cis rs290986 0.857 rs158509 chr9:93546449 C/G cg02608019 chr9:93564028 SYK 0.5 5.38 0.31 1.61e-7 Multiple sclerosis; CESC cis rs6582630 0.537 rs11520294 chr12:38402705 C/A cg13010199 chr12:38710504 ALG10B 0.54 6.87 0.39 4.7e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs1144333 1.000 rs5745327 chr1:76270040 A/T cg03433033 chr1:76189801 ACADM -0.53 -5.5 -0.32 8.83e-8 Attention function in attention deficit hyperactive disorder; CESC trans rs7944735 0.507 rs10742827 chr11:48102350 C/T cg03929089 chr4:120376271 NA 0.55 6.56 0.37 2.87e-10 Intraocular pressure; CESC cis rs12545109 0.879 rs2576580 chr8:57365828 G/C cg09654669 chr8:57350985 NA -0.57 -6.67 -0.38 1.46e-10 Obesity-related traits; CESC cis rs208520 0.690 rs207077 chr6:66769855 A/C cg07460842 chr6:66804631 NA -0.96 -12.78 -0.62 1.87e-29 Exhaled nitric oxide output; CESC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg04317338 chr11:64019027 PLCB3 -0.87 -9.28 -0.5 6.19e-18 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00346556 chr12:15942191 EPS8 0.51 6.06 0.35 4.62e-9 Gut microbiome composition (summer); CESC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg11301795 chr4:187892539 NA -0.81 -14.41 -0.66 3.69e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg21963583 chr11:68658836 MRPL21 0.39 5.6 0.33 5.26e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6460942 0.511 rs13245890 chr7:12543134 A/C cg02935154 chr7:12443704 VWDE -0.56 -5.53 -0.32 7.57e-8 Coronary artery disease; CESC cis rs2573652 1.000 rs2581358 chr15:100513725 C/G cg09918751 chr15:100517450 ADAMTS17 -0.39 -7.57 -0.42 6.24e-13 Height; CESC cis rs78456975 1.000 rs13431491 chr2:1553808 T/A cg26248373 chr2:1572462 NA -0.58 -5.48 -0.32 9.71e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7818688 1.000 rs28712702 chr8:96026980 G/A cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs4474465 0.850 rs10793332 chr11:78270020 C/G cg27205649 chr11:78285834 NARS2 0.45 5.9 0.34 1.11e-8 Alzheimer's disease (survival time); CESC cis rs2243480 1.000 rs1267820 chr7:66050295 C/G cg13147721 chr7:65941812 NA -0.93 -8.79 -0.47 1.98e-16 Diabetic kidney disease; CESC cis rs2749592 0.588 rs2505192 chr10:38395023 G/A cg25427524 chr10:38739819 LOC399744 -0.62 -8.3 -0.45 5.37e-15 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs17376456 0.809 rs13177800 chr5:93307350 T/C cg25358565 chr5:93447407 FAM172A 1.11 10.49 0.54 9.3e-22 Diabetic retinopathy; CESC cis rs9393777 0.623 rs16891717 chr6:26477143 T/A cg12826209 chr6:26865740 GUSBL1 0.65 6.85 0.39 5.16e-11 Intelligence (multi-trait analysis); CESC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg24675658 chr1:53192096 ZYG11B -0.53 -6.82 -0.39 6.32e-11 Monocyte count; CESC cis rs4919694 1.000 rs12258551 chr10:104767892 C/G cg04362960 chr10:104952993 NT5C2 0.75 6.44 0.37 5.54e-10 Arsenic metabolism; CESC cis rs9790314 0.846 rs9809522 chr3:160983768 G/C cg03342759 chr3:160939853 NMD3 -0.51 -7.39 -0.41 1.98e-12 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25495775 chr17:46970705 ATP5G1 -0.56 -6.78 -0.38 7.68e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15979344 chr10:99496871 ZFYVE27 0.55 6.69 0.38 1.3e-10 Gut microbiome composition (summer); CESC trans rs12310956 0.532 rs11052952 chr12:33988048 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.14 0.45 1.56e-14 Morning vs. evening chronotype; CESC trans rs1728785 1.000 rs1749791 chr16:68572347 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.44 0.42 1.41e-12 Ulcerative colitis; CESC cis rs4481887 0.927 rs11204637 chr1:248492581 G/A cg00666640 chr1:248458726 OR2T12 0.36 6.17 0.35 2.56e-9 Common traits (Other); CESC cis rs12142240 0.698 rs1057535 chr1:46815898 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs9287719 0.967 rs6432116 chr2:10748615 T/C cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg26338869 chr17:61819248 STRADA 0.67 8.74 0.47 2.72e-16 Prudent dietary pattern; CESC cis rs698833 0.886 rs4953090 chr2:44565194 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.55 6.96 0.39 2.69e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs17601876 0.814 rs8029537 chr15:51557698 A/G cg19946085 chr15:51559439 CYP19A1 -0.35 -5.63 -0.33 4.54e-8 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18145393 chr4:520203 PIGG 0.52 6.78 0.38 7.92e-11 Fibrinogen levels; CESC cis rs425277 0.917 rs78609670 chr1:2045886 G/T cg16545954 chr1:2118288 C1orf86 0.33 5.4 0.31 1.48e-7 Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26635474 chr16:1706710 CRAMP1L -0.41 -6.03 -0.35 5.43e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs17376456 0.569 rs2045019 chr5:93201971 C/T cg25358565 chr5:93447407 FAM172A -0.71 -7.62 -0.42 4.44e-13 Diabetic retinopathy; CESC cis rs2180341 0.618 rs12529077 chr6:127634244 G/T cg24812749 chr6:127587940 RNF146 0.6 8.09 0.44 2.22e-14 Breast cancer; CESC cis rs35522438 1 rs35522438 chr7:91872872 A/AT cg17063962 chr7:91808500 NA 0.59 8.09 0.45 2.1e-14 Breast cancer; CESC trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg15704280 chr7:45808275 SEPT13 0.82 12.25 0.6 1.2100000000000001e-27 Height; CESC cis rs782590 0.902 rs2586947 chr2:55854009 C/G cg18811423 chr2:55921094 PNPT1 0.76 11.74 0.58 6.83e-26 Metabolic syndrome; CESC cis rs763014 0.931 rs11643039 chr16:634260 G/A cg00802000 chr16:706648 WDR90 -0.4 -6.09 -0.35 4.02e-9 Height; CESC cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.17 0.3 4.54e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11098499 0.691 rs2136911 chr4:120265859 G/A cg25214090 chr10:38739885 LOC399744 0.59 8.14 0.45 1.55e-14 Corneal astigmatism; CESC cis rs796364 0.616 rs769956 chr2:200693720 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.53 -5.11 -0.3 6.17e-7 Schizophrenia; CESC cis rs2066819 1.000 rs59811639 chr12:56695954 C/T cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs8103278 1.000 rs8108864 chr19:46301671 G/A cg12641515 chr19:46296257 DMWD -0.52 -5.81 -0.34 1.76e-8 Coronary artery disease; CESC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg12143784 chr7:64541923 NA 0.43 5.63 0.33 4.64e-8 Calcium levels; CESC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg21248554 chr2:27665150 KRTCAP3 -0.29 -6.18 -0.36 2.35e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg18404041 chr3:52824283 ITIH1 -0.37 -6.17 -0.35 2.53e-9 Bipolar disorder; CESC cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg03060546 chr3:49711283 APEH 0.45 5.5 0.32 9e-8 Parkinson's disease; CESC cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg22834771 chr12:69754056 YEATS4 -0.43 -5.67 -0.33 3.67e-8 Blood protein levels; CESC cis rs9549260 0.712 rs1334241 chr13:41223110 C/T cg21288729 chr13:41239152 FOXO1 0.54 5.31 0.31 2.33e-7 Red blood cell count; CESC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg04267008 chr7:1944627 MAD1L1 0.6 7.27 0.41 3.94e-12 Bipolar disorder and schizophrenia; CESC trans rs2727020 0.566 rs10839234 chr11:49185524 C/T cg15704280 chr7:45808275 SEPT13 -0.85 -13.78 -0.65 6.19e-33 Coronary artery disease; CESC cis rs8040855 0.627 rs17541051 chr15:85649353 C/G cg08123816 chr15:85640762 PDE8A -0.39 -5.74 -0.33 2.6e-8 Bulimia nervosa; CESC cis rs9486719 1.000 rs2499809 chr6:96870110 C/T cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs926392 0.572 rs6129158 chr20:37673967 A/G cg16355469 chr20:37678765 NA 0.57 7.17 0.4 7.44e-12 Dialysis-related mortality; CESC cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg00149659 chr3:10157352 C3orf10 1.01 12.53 0.61 1.33e-28 Alzheimer's disease; CESC cis rs7714584 1.000 rs4958842 chr5:150224877 G/A cg22134413 chr5:150180641 NA 0.62 5.94 0.34 8.89e-9 Crohn's disease; CESC cis rs28489187 0.706 rs233067 chr1:85804978 C/G cg16011679 chr1:85725395 C1orf52 0.48 5.59 0.33 5.51e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs2370759 0.891 rs77706860 chr10:32628537 C/T cg01819863 chr10:32635814 EPC1 1.12 10.39 0.54 1.99e-21 Sexual dysfunction (female); CESC cis rs12048904 0.964 rs3188491 chr1:101338482 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.53 6.81 0.39 6.4e-11 Multiple sclerosis; CESC trans rs7945705 0.902 rs2568059 chr11:8884161 T/C cg10637292 chr12:52960529 KRT74 0.35 6.18 0.35 2.42e-9 Hemoglobin concentration; CESC cis rs2180341 0.961 rs9375501 chr6:127652539 C/T cg27446573 chr6:127587934 RNF146 1.09 16.35 0.71 5.12e-42 Breast cancer; CESC cis rs7615952 0.800 rs35390120 chr3:125599809 G/A cg05084668 chr3:125655381 ALG1L -0.6 -6.48 -0.37 4.49e-10 Blood pressure (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07373003 chr10:22614444 BMI1 0.56 6.12 0.35 3.41e-9 Gut microbiome composition (summer); CESC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg15602633 chr10:134698661 NA 0.33 6.06 0.35 4.55e-9 Tuberculosis; CESC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg07701084 chr6:150067640 NUP43 0.46 6.49 0.37 4.3e-10 Lung cancer; CESC cis rs9902453 0.904 rs4461132 chr17:28423430 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 9.02 0.48 3.81e-17 Coffee consumption (cups per day); CESC cis rs34779708 0.966 rs11010102 chr10:35411066 T/A cg03585969 chr10:35415529 CREM 0.77 10.38 0.54 2.06e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs12900413 0.687 rs12902786 chr15:90304376 G/A cg24249390 chr15:90295951 MESP1 -0.4 -5.57 -0.32 6.23e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs7267979 1.000 rs6050598 chr20:25397257 C/G cg08601574 chr20:25228251 PYGB 0.37 5.37 0.31 1.7e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2380220 0.808 rs2716072 chr6:95909773 A/G cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg02221750 chr19:17393354 ANKLE1 -0.51 -6.24 -0.36 1.71e-9 Systemic lupus erythematosus; CESC cis rs642858 0.784 rs592755 chr6:140237606 A/G cg27524944 chr6:140295369 NA 0.35 5.18 0.3 4.3e-7 Type 2 diabetes; CESC cis rs16917546 0.967 rs10995256 chr10:64402434 G/T cg03961010 chr10:64397487 ZNF365 -0.37 -6.11 -0.35 3.47e-9 Basal cell carcinoma; CESC cis rs11098499 0.955 rs13114751 chr4:120156617 G/A cg24375607 chr4:120327624 NA 0.43 5.15 0.3 5.05e-7 Corneal astigmatism; CESC cis rs9788682 0.747 rs2656073 chr15:78742276 G/T cg24631222 chr15:78858424 CHRNA5 0.65 7.64 0.43 3.9e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg22433210 chr17:43662623 NA -0.91 -10.51 -0.54 7.86e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11650494 0.908 rs11656535 chr17:47425588 C/T cg08112188 chr17:47440006 ZNF652 1.11 7.72 0.43 2.31e-13 Prostate cancer; CESC cis rs7772486 0.738 rs2246334 chr6:146183635 G/A cg05347473 chr6:146136440 FBXO30 0.59 7.54 0.42 7.31e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg20430063 chr12:65672888 MSRB3 0.48 6.08 0.35 4.17e-9 Psoriatic arthritis; CESC cis rs67366981 0.925 rs41438045 chr14:77692781 A/T cg22824376 chr14:77648248 TMEM63C 0.64 5.32 0.31 2.23e-7 Obsessive-compulsive symptoms; CESC cis rs7216064 1.000 rs9897982 chr17:65879592 G/T cg07042672 chr17:66097459 LOC651250 -0.62 -7.45 -0.42 1.35e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg01416388 chr22:39784598 NA 0.59 7.24 0.41 4.87e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg23161317 chr6:28129485 ZNF389 0.51 6.63 0.38 1.85e-10 Depression; CESC cis rs4969178 0.896 rs11077361 chr17:76397128 A/G cg05887092 chr17:76393375 PGS1 0.58 9.2 0.49 1.13e-17 HDL cholesterol levels; CESC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg04944784 chr2:26401820 FAM59B -0.66 -7.66 -0.43 3.61e-13 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02653728 chr5:132165751 NA -0.49 -6.75 -0.38 9.32e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28489187 0.617 rs233072 chr1:85807695 A/G cg16011679 chr1:85725395 C1orf52 0.45 5.33 0.31 2.12e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg05863683 chr7:1912471 MAD1L1 0.37 5.38 0.31 1.64e-7 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03032015 chr1:142618752 NA -0.56 -6.88 -0.39 4.26e-11 Gut microbiome composition (summer); CESC cis rs2286503 0.839 rs4722188 chr7:22860211 C/G cg11367502 chr7:22862612 TOMM7 0.39 5.28 0.31 2.72e-7 Fibrinogen; CESC cis rs7246657 0.943 rs6508732 chr19:38000468 C/T cg23950597 chr19:37808831 NA -0.49 -5.49 -0.32 9.38e-8 Coronary artery calcification; CESC cis rs1008375 1.000 rs555 chr4:17625658 A/G cg15017067 chr4:17643749 FAM184B 0.39 5.68 0.33 3.58e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs561341 1.000 rs8069199 chr17:30281845 A/G cg20587970 chr11:113659929 NA -1.12 -14.24 -0.66 1.49e-34 Hip circumference adjusted for BMI; CESC cis rs80282103 0.618 rs74117848 chr10:1160974 T/G cg08668510 chr10:1095578 IDI1 0.75 6.01 0.35 5.97e-9 Glomerular filtration rate (creatinine); CESC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg06481639 chr22:41940642 POLR3H 0.6 5.95 0.34 8.27e-9 Cannabis dependence symptom count; CESC cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg05585544 chr11:47624801 NA -0.5 -7.19 -0.4 6.51e-12 Subjective well-being; CESC cis rs79349575 0.778 rs12950328 chr17:46967061 C/T cg16584676 chr17:46985605 UBE2Z 0.55 6.62 0.38 2.03e-10 Type 2 diabetes; CESC trans rs4388249 0.516 rs435494 chr5:109010578 G/C cg00054525 chr16:88717587 CYBA -0.61 -6.8 -0.39 7.05e-11 Schizophrenia; CESC cis rs67311347 1.000 rs11539046 chr3:40503809 G/A cg24209194 chr3:40518798 ZNF619 -0.54 -7.02 -0.4 1.9e-11 Renal cell carcinoma; CESC cis rs1395 0.626 rs72817537 chr2:27497549 G/A cg22903471 chr2:27725779 GCKR -0.5 -5.85 -0.34 1.46e-8 Blood metabolite levels; CESC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.56 6.9 0.39 3.81e-11 Height; CESC cis rs7927771 0.864 rs3781627 chr11:47441472 T/A cg20307385 chr11:47447363 PSMC3 0.71 8.78 0.47 2.01e-16 Subjective well-being; CESC cis rs9611565 0.546 rs132793 chr22:42063681 A/G cg06634786 chr22:41940651 POLR3H 0.61 5.97 0.34 7.66e-9 Vitiligo; CESC cis rs9457247 0.967 rs433191 chr6:167409662 T/A cg23791538 chr6:167370224 RNASET2 -0.61 -8.75 -0.47 2.59e-16 Crohn's disease; CESC cis rs4253772 0.575 rs9615979 chr22:46789021 G/T cg24881330 chr22:46731750 TRMU 0.78 5.18 0.3 4.38e-7 LDL cholesterol;Cholesterol, total; CESC cis rs116095464 0.558 rs10067021 chr5:221490 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.74 0.33 2.63e-8 Breast cancer; CESC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg00310523 chr12:86230176 RASSF9 0.37 5.63 0.33 4.47e-8 Major depressive disorder; CESC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg20151795 chr6:28129481 ZNF389 -0.49 -6.57 -0.37 2.58e-10 Depression; CESC cis rs61008539 0.586 rs6959154 chr7:856320 C/T cg00934597 chr7:893267 UNC84A -0.51 -6.75 -0.38 9.31e-11 Perceived unattractiveness to mosquitoes; CESC cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.21 0.31 3.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.73 0.33 2.71e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6963495 0.818 rs115609508 chr7:105163716 C/A cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs4243830 0.850 rs13513 chr1:6585804 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.77 -7.91 -0.44 7.21e-14 Body mass index; CESC cis rs988913 1.000 rs1393776 chr6:54763018 A/C cg03513858 chr6:54763001 FAM83B 0.37 5.32 0.31 2.21e-7 Menarche (age at onset); CESC cis rs12701220 0.739 rs2293523 chr7:1098518 G/A cg26769984 chr7:1090371 C7orf50 0.58 5.92 0.34 1.01e-8 Bronchopulmonary dysplasia; CESC cis rs11969893 0.850 rs9498409 chr6:101299966 G/A cg12253828 chr6:101329408 ASCC3 1.14 9.68 0.51 3.71e-19 Economic and political preferences (immigration/crime); CESC cis rs6752107 0.837 rs3792108 chr2:234184952 T/C cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.39 5.91 0.34 1.07e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs921968 0.542 rs588182 chr2:219412335 C/A cg02176678 chr2:219576539 TTLL4 0.5 9.06 0.49 3.06e-17 Mean corpuscular hemoglobin concentration; CESC cis rs796364 0.951 rs11897245 chr2:201063644 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.55 5.36 0.31 1.86e-7 Schizophrenia; CESC trans rs11098499 0.954 rs10008459 chr4:120394231 T/C cg25214090 chr10:38739885 LOC399744 0.7 10.29 0.53 4.26e-21 Corneal astigmatism; CESC cis rs644799 0.710 rs519511 chr11:95538270 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.77 10.82 0.55 8.02e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3820928 0.605 rs6748311 chr2:227792530 T/A cg11843606 chr2:227700838 RHBDD1 -0.56 -7.76 -0.43 1.87e-13 Pulmonary function; CESC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg14926445 chr8:58193284 C8orf71 -0.5 -5.39 -0.31 1.6e-7 Developmental language disorder (linguistic errors); CESC cis rs67311347 0.956 rs4974029 chr3:40521318 C/G cg24209194 chr3:40518798 ZNF619 0.54 7.15 0.4 8.34e-12 Renal cell carcinoma; CESC cis rs12477438 0.501 rs6753063 chr2:99801469 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 15.36 0.69 1.63e-38 Chronic sinus infection; CESC cis rs6582630 0.516 rs8186746 chr12:38347638 G/T cg26384229 chr12:38710491 ALG10B -0.47 -6.06 -0.35 4.54e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs9788682 0.948 rs34664138 chr15:78831624 T/G cg24631222 chr15:78858424 CHRNA5 0.81 10.53 0.54 6.79e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18102949 chr7:128116732 METTL2B 0.69 7.9 0.44 7.64e-14 Gut microbiome composition (summer); CESC cis rs916888 0.687 rs199456 chr17:44797919 C/T cg17911788 chr17:44343683 NA -0.63 -8.15 -0.45 1.45e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg11663144 chr21:46675770 NA -0.62 -9.74 -0.51 2.36e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6901250 0.851 rs6938235 chr6:117147946 G/T cg12892004 chr6:117198278 RFX6 0.27 5.07 0.3 7.65e-7 C-reactive protein levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05995172 chr11:57434667 ZDHHC5 -0.47 -6.42 -0.37 6.16e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs9467711 0.659 rs13216828 chr6:26373507 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -7.09 -0.4 1.23e-11 Autism spectrum disorder or schizophrenia; CESC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.702 rs17233868 chr16:89803629 C/T cg04013166 chr16:89971882 TCF25 0.76 6.51 0.37 3.7e-10 Skin colour saturation; CESC trans rs2235573 0.527 rs139879 chr22:38364552 T/C cg19894588 chr14:64061835 NA 0.63 8.32 0.46 4.69e-15 Glioblastoma;Glioma; CESC cis rs9309473 0.607 rs1851546 chr2:73591127 C/A cg20560298 chr2:73613845 ALMS1 -0.45 -5.69 -0.33 3.44e-8 Metabolite levels; CESC cis rs344364 0.511 rs337286 chr16:1965719 C/T cg03013636 chr16:1946785 NA 0.43 5.5 0.32 8.99e-8 Glomerular filtration rate in chronic kidney disease; CESC cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg11812906 chr14:75593930 NEK9 0.88 14.52 0.67 1.47e-35 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09059988 chr1:150693299 HORMAD1 -0.46 -6.46 -0.37 4.88e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7586879 0.616 rs11900505 chr2:25131986 A/C cg01884057 chr2:25150051 NA 0.36 6.87 0.39 4.46e-11 Body mass index; CESC cis rs3008870 0.755 rs2815366 chr1:67499930 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 7.97 0.44 4.75e-14 Lymphocyte percentage of white cells; CESC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg04166393 chr7:2884313 GNA12 0.59 7.45 0.42 1.32e-12 Height; CESC cis rs6121246 0.609 rs6089075 chr20:30392884 A/G cg13852791 chr20:30311386 BCL2L1 0.82 10.49 0.54 9.55e-22 Mean corpuscular hemoglobin; CESC cis rs9487051 0.660 rs2884036 chr6:109642916 A/G cg01475377 chr6:109611718 NA 0.45 6.5 0.37 3.95e-10 Reticulocyte fraction of red cells; CESC cis rs5769765 0.658 rs2157536 chr22:50190180 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.46 -5.16 -0.3 4.78e-7 Schizophrenia; CESC cis rs1784581 0.894 rs1790001 chr6:162387504 G/T cg17173639 chr6:162384350 PARK2 -0.8 -12.97 -0.62 4.11e-30 Itch intensity from mosquito bite; CESC cis rs734999 0.588 rs11585048 chr1:2534087 C/T cg18854424 chr1:2615690 NA 0.27 5.23 0.31 3.49e-7 Ulcerative colitis; CESC cis rs9359856 0.564 rs72915918 chr6:90430792 G/C cg13799429 chr6:90582589 CASP8AP2 -0.59 -5.58 -0.32 6.07e-8 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12754671 chr1:161171876 NDUFS2 -0.4 -6.18 -0.35 2.47e-9 Gambling; CESC cis rs2742234 0.590 rs2257767 chr10:43657811 T/G cg15436174 chr10:43711423 RASGEF1A -0.51 -5.84 -0.34 1.54e-8 Hirschsprung disease; CESC cis rs7267979 1.000 rs6083828 chr20:25369918 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -16.93 -0.72 4.43e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs7605827 0.930 rs2058867 chr2:15520153 T/C cg19274914 chr2:15703543 NA 0.36 6.45 0.37 5.37e-10 Educational attainment (years of education); CESC cis rs2072732 0.861 rs2993510 chr1:2956666 C/T cg15211996 chr1:2936768 ACTRT2 -0.33 -6.14 -0.35 2.99e-9 Plateletcrit; CESC cis rs36051895 0.664 rs10117459 chr9:5094034 G/A cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.61e-9 Pediatric autoimmune diseases; CESC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs7818688 0.697 rs80217195 chr8:95986853 T/C cg16049864 chr8:95962084 TP53INP1 0.55 5.58 0.32 5.99e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05458841 chr5:65221764 ERBB2IP 0.62 7.85 0.43 1.04e-13 Gut microbiome composition (summer); CESC cis rs9811920 0.641 rs58704213 chr3:99690331 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -6.29 -0.36 1.3e-9 Axial length; CESC cis rs4662945 0.525 rs4662951 chr2:130256272 C/T cg05903289 chr2:130345205 NA -0.41 -6.35 -0.36 9.19e-10 Response to cytidine analogues (gemcitabine); CESC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg11742103 chr11:62369870 EML3;MTA2 0.6 9.23 0.49 8.91e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7086627 0.515 rs10887901 chr10:82210581 G/A cg03267442 chr10:82210566 NA -0.33 -5.49 -0.32 9.45e-8 Post bronchodilator FEV1; CESC cis rs7116495 1.000 rs73543633 chr11:71828844 T/C cg10381502 chr11:71823885 C11orf51 0.72 5.91 0.34 1.05e-8 Severe influenza A (H1N1) infection; CESC cis rs17376456 0.825 rs10078941 chr5:93279029 C/T cg25358565 chr5:93447407 FAM172A 1.11 10.16 0.53 1.06e-20 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03956243 chr12:54059090 ATP5G2 -0.68 -8.35 -0.46 3.8e-15 Gut microbiome composition (summer); CESC cis rs829883 0.659 rs12366950 chr12:98947900 T/C cg25150519 chr12:98850993 NA -0.61 -7.37 -0.41 2.23e-12 Colorectal adenoma (advanced); CESC cis rs6460942 0.731 rs75994414 chr7:12307992 C/A cg06484146 chr7:12443880 VWDE -0.78 -8.3 -0.45 5.42e-15 Coronary artery disease; CESC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.48 -0.32 9.67e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6728642 0.908 rs17842456 chr2:98014319 C/T cg26665480 chr2:98280029 ACTR1B 0.76 6.99 0.39 2.28e-11 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs9457247 0.905 rs453184 chr6:167387404 A/C cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC cis rs7264396 0.623 rs2425123 chr20:34329547 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.86 0.39 4.77e-11 Total cholesterol levels; CESC cis rs10465746 0.905 rs1324484 chr1:84382844 T/C cg10977910 chr1:84465055 TTLL7 0.46 6.17 0.35 2.51e-9 Obesity-related traits; CESC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.34 0.41 2.56e-12 Tonsillectomy; CESC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.48 0.37 4.53e-10 Bipolar disorder; CESC cis rs7216064 1.000 rs8072225 chr17:65912960 A/G cg07042672 chr17:66097459 LOC651250 -0.61 -7.66 -0.43 3.45e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg11764359 chr7:65958608 NA -0.94 -15.49 -0.69 5.83e-39 Aortic root size; CESC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg22974920 chr21:40686053 BRWD1 -0.42 -5.17 -0.3 4.7e-7 Cognitive function; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg13834670 chr9:129677390 RALGPS1 -0.4 -6.06 -0.35 4.6e-9 Breast cancer; CESC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.11 0.3 6.08e-7 Personality dimensions; CESC cis rs9917256 1.000 rs13016703 chr2:169155595 T/G cg07857142 chr2:169103971 STK39 0.58 5.3 0.31 2.48e-7 Parkinson's disease; CESC cis rs2439831 1.000 rs2245790 chr15:43744457 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.56 0.54 5.55e-22 Lung cancer in ever smokers; CESC cis rs1008375 1.000 rs6811887 chr4:17640858 C/T cg15017067 chr4:17643749 FAM184B 0.36 5.11 0.3 6.3e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11098499 0.863 rs6534141 chr4:120485223 A/T cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.27e-28 Corneal astigmatism; CESC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.69 0.43 2.93e-13 Prudent dietary pattern; CESC cis rs933688 1.000 rs12654787 chr5:90713259 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.82 0.59 3.43e-26 Smoking behavior; CESC cis rs72781680 0.898 rs72780123 chr2:23996009 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs858239 0.600 rs28483572 chr7:23131785 A/G cg23682824 chr7:23144976 KLHL7 0.55 7.61 0.42 4.84e-13 Cerebrospinal fluid biomarker levels; CESC cis rs1707322 1.000 rs11211235 chr1:46440375 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg23048001 chr7:2026167 MAD1L1 0.42 5.29 0.31 2.6e-7 Bipolar disorder and schizophrenia; CESC trans rs2727020 0.729 rs2299650 chr11:49174007 A/C cg15704280 chr7:45808275 SEPT13 -0.84 -13.74 -0.65 8.15e-33 Coronary artery disease; CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg10150615 chr22:24372951 LOC391322 -0.58 -7.87 -0.44 9.21e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs909674 0.731 rs6001594 chr22:39837472 C/T cg02038168 chr22:39784481 NA -0.69 -8.63 -0.47 5.92e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg24549020 chr5:56110836 MAP3K1 0.47 5.82 0.34 1.66e-8 Initial pursuit acceleration; CESC cis rs7512552 0.839 rs486275 chr1:150282784 G/A cg15654264 chr1:150340011 RPRD2 -0.4 -5.25 -0.31 3.06e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg18240062 chr17:79603768 NPLOC4 0.72 10.27 0.53 4.71e-21 Eye color traits; CESC cis rs9911578 0.967 rs6503883 chr17:56917543 C/T cg12560992 chr17:57184187 TRIM37 0.94 15.75 0.7 6.57e-40 Intelligence (multi-trait analysis); CESC cis rs11690935 1.000 rs312925 chr2:172563922 G/A cg13550731 chr2:172543902 DYNC1I2 -0.95 -14.62 -0.67 6.75e-36 Schizophrenia; CESC cis rs7827545 1.000 rs7008121 chr8:135565904 T/C cg17885191 chr8:135476712 NA 0.49 6.36 0.36 8.72e-10 Hypertension (SNP x SNP interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00399650 chr7:141402322 KIAA1147 -0.44 -6.66 -0.38 1.54e-10 Gambling; CESC cis rs863345 0.604 rs7512592 chr1:158489945 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC cis rs7429990 0.931 rs62262084 chr3:47653822 C/T cg11946769 chr3:48343235 NME6 0.53 5.34 0.31 2.04e-7 Educational attainment (years of education); CESC cis rs3733585 0.699 rs6844316 chr4:9958977 A/G cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg09177884 chr7:1199841 ZFAND2A -0.46 -5.73 -0.33 2.66e-8 Longevity;Endometriosis; CESC cis rs367943 0.634 rs6594701 chr5:112685743 C/T cg12552261 chr5:112820674 MCC 0.42 5.42 0.32 1.36e-7 Type 2 diabetes; CESC cis rs7100689 0.725 rs2185425 chr10:82139941 T/C cg00277334 chr10:82204260 NA -0.61 -7.65 -0.43 3.66e-13 Post bronchodilator FEV1; CESC cis rs7726839 0.574 rs11134149 chr5:637277 A/G cg16447950 chr5:562315 NA -0.6 -6.7 -0.38 1.27e-10 Obesity-related traits; CESC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg18758796 chr5:131593413 PDLIM4 -0.44 -6.04 -0.35 5.26e-9 Breast cancer; CESC cis rs3126085 1.000 rs2011331 chr1:152286002 T/C cg03465714 chr1:152285911 FLG 0.41 5.05 0.3 8.31e-7 Atopic dermatitis; CESC cis rs6736093 0.796 rs13006228 chr2:112806738 G/A cg12686935 chr2:112915763 FBLN7 -0.43 -5.63 -0.33 4.55e-8 Coronary artery disease; CESC cis rs959260 0.925 rs4788890 chr17:73389446 A/G cg12999837 chr17:73267436 MIF4GD -0.51 -5.74 -0.33 2.57e-8 Systemic lupus erythematosus; CESC cis rs1949733 0.958 rs2631731 chr4:8429817 A/G cg11789530 chr4:8429930 ACOX3 0.82 11.91 0.59 1.8e-26 Response to antineoplastic agents; CESC cis rs12971120 0.838 rs747176 chr18:72154931 G/A cg25817165 chr18:72167213 CNDP2 -0.49 -6.36 -0.36 8.97e-10 Refractive error; CESC cis rs7598759 0.712 rs12991636 chr2:232333666 T/C cg19187155 chr2:232395269 NMUR1 0.41 6.37 0.36 8.46e-10 Noise-induced hearing loss; CESC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg22535103 chr8:58192502 C8orf71 0.8 9.09 0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs1577917 0.771 rs2475791 chr6:86368164 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -7.36 -0.41 2.29e-12 Response to antipsychotic treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03046325 chr10:93558661 TNKS2 0.53 6.33 0.36 1.06e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18194353 chr1:100315666 AGL 0.61 7.41 0.41 1.65e-12 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.63 0.38 1.83e-10 Bipolar disorder; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg02357637 chr15:100268975 LYSMD4 0.43 6.44 0.37 5.44e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg02487422 chr3:49467188 NICN1 0.5 6.35 0.36 9.14e-10 Parkinson's disease; CESC cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg21138405 chr5:131827807 IRF1 0.57 9.05 0.49 3.24e-17 Asthma (sex interaction); CESC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.91 0.34 1.07e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg08499158 chr17:42289980 UBTF -0.42 -5.44 -0.32 1.23e-7 Bone mineral density (hip);Bone mineral density; CESC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.39 -0.31 1.53e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6783573 0.683 rs3806702 chr3:46617502 T/C cg27371741 chr3:46619158 LRRC2;TDGF1 -0.38 -5.95 -0.34 8.42e-9 Cerebrospinal fluid biomarker levels; CESC cis rs3540 0.553 rs2158406 chr15:90994499 T/C cg10434728 chr15:90938212 IQGAP1 0.42 7.49 0.42 1.05e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs7188697 0.775 rs8056620 chr16:58604387 T/A cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg18876405 chr7:65276391 NA 0.45 6.18 0.35 2.39e-9 Aortic root size; CESC trans rs8007846 0.569 rs4400971 chr14:66254578 A/C cg13219509 chr22:40440322 TNRC6B 0.5 6.6 0.38 2.27e-10 Multiple sclerosis--Brain Glutamate Levels; CESC cis rs870825 0.616 rs6552805 chr4:185637894 C/A cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg00310523 chr12:86230176 RASSF9 0.37 5.5 0.32 9.17e-8 Major depressive disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17181325 chr17:1613831 TLCD2 -0.44 -6.25 -0.36 1.61e-9 Fibrinogen levels; CESC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg22823121 chr1:150693482 HORMAD1 -0.37 -5.46 -0.32 1.12e-7 Tonsillectomy; CESC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg14664628 chr15:75095509 CSK -0.65 -8.56 -0.47 9.13e-16 Breast cancer; CESC cis rs7851660 0.844 rs10119853 chr9:100624981 G/A cg13688889 chr9:100608707 NA -0.64 -8.89 -0.48 9.61e-17 Strep throat; CESC cis rs6503863 1 rs6503863 chr17:56517034 G/A cg12560992 chr17:57184187 TRIM37 0.62 8.43 0.46 2.28e-15 Intelligence (multi-trait analysis); CESC cis rs4523957 0.570 rs2126202 chr17:2095712 G/T cg16513277 chr17:2031491 SMG6 0.41 5.54 0.32 7.31e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9443189 0.570 rs523465 chr6:76330434 G/C cg01950844 chr6:76311363 SENP6 0.87 9.29 0.5 6.04e-18 Prostate cancer; CESC cis rs12541635 0.653 rs7014265 chr8:107026412 G/A cg10147462 chr8:107024639 NA 0.42 6.25 0.36 1.65e-9 Age of smoking initiation; CESC cis rs27434 0.583 rs34762 chr5:96153966 A/G cg16492584 chr5:96139282 ERAP1 -0.38 -5.54 -0.32 7.47e-8 Ankylosing spondylitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02576610 chr16:75657395 ADAT1 -0.59 -6.98 -0.39 2.34e-11 Gut microbiome composition (summer); CESC cis rs7584330 0.518 rs80282956 chr2:238447929 G/A cg14458575 chr2:238380390 NA 0.67 6.2 0.36 2.14e-9 Prostate cancer; CESC cis rs1878931 0.696 rs35984213 chr16:3451030 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 1.07 17.87 0.74 2.07e-47 Body mass index (adult); CESC cis rs1775715 0.678 rs2105360 chr10:32210198 C/T cg04359828 chr10:32216031 ARHGAP12 0.35 5.04 0.3 8.57e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6088813 1.000 rs6142379 chr20:33999267 A/G cg14752227 chr20:34000481 UQCC -0.39 -5.06 -0.3 7.88e-7 Height; CESC cis rs7100689 0.754 rs10736339 chr10:82059970 G/C cg00277334 chr10:82204260 NA -0.58 -7.37 -0.41 2.2e-12 Post bronchodilator FEV1; CESC cis rs9916302 0.904 rs8076546 chr17:37555403 G/A cg07936489 chr17:37558343 FBXL20 0.79 11.49 0.58 4.71e-25 Glomerular filtration rate (creatinine); CESC cis rs2204008 0.583 rs12820907 chr12:37990931 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.68 0.33 3.46e-8 Bladder cancer; CESC cis rs2180341 0.711 rs4371861 chr6:127568447 G/T cg24812749 chr6:127587940 RNF146 0.67 9.64 0.51 4.63e-19 Breast cancer; CESC trans rs61931739 0.534 rs7133262 chr12:34279444 G/A cg26384229 chr12:38710491 ALG10B 0.64 9.21 0.49 1.01e-17 Morning vs. evening chronotype; CESC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg09165964 chr15:75287851 SCAMP5 0.45 6.09 0.35 3.99e-9 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00568128 chr10:115934100 MIR2110;C10orf118 -0.42 -6.03 -0.35 5.38e-9 Gambling; CESC cis rs116095464 0.558 rs1971229 chr5:268187 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.86e-15 Breast cancer; CESC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg05313129 chr8:58192883 C8orf71 -0.5 -5.05 -0.3 8.06e-7 Developmental language disorder (linguistic errors); CESC cis rs68170813 0.559 rs58319984 chr7:106965794 G/A cg02696742 chr7:106810147 HBP1 -0.54 -5.17 -0.3 4.66e-7 Coronary artery disease; CESC cis rs9303280 0.806 rs10445308 chr17:37938047 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.66 -0.33 3.9e-8 Self-reported allergy; CESC cis rs796364 0.906 rs1658810 chr2:200816382 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 8.35 0.46 3.96e-15 Schizophrenia; CESC cis rs12042938 1.000 rs4366301 chr1:231806286 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.46 -6.39 -0.37 7.31e-10 Neuranatomic and neurocognitive phenotypes; CESC cis rs4900538 0.963 rs4906205 chr14:102932447 A/G cg18135206 chr14:102964638 TECPR2 0.78 10.53 0.54 7.1e-22 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16143763 chr17:41116517 AARSD1 -0.5 -6.06 -0.35 4.76e-9 Ulcerative colitis; CESC cis rs7208859 0.623 rs73269988 chr17:29118145 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.37 -0.54 2.25e-21 Alzheimer's disease; CESC cis rs698813 0.674 rs4952707 chr2:44500683 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.13 0.3 5.66e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs34779708 0.931 rs1926556 chr10:35344907 T/C cg04310649 chr10:35416472 CREM -0.49 -5.87 -0.34 1.31e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs11997175 0.646 rs55898196 chr8:33765862 A/G ch.8.33884649F chr8:33765107 NA 0.55 6.93 0.39 3.17e-11 Body mass index; CESC cis rs11249608 0.548 rs13156530 chr5:178475017 C/T cg21905437 chr5:178450457 ZNF879 0.55 7.58 0.42 6e-13 Pubertal anthropometrics; CESC cis rs7208859 0.673 rs11654914 chr17:29229424 C/G cg19761014 chr17:28927070 LRRC37B2 0.64 5.32 0.31 2.2e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs61931739 0.500 rs11053198 chr12:34444013 G/C cg26384229 chr12:38710491 ALG10B 0.54 7.5 0.42 9.79e-13 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16324876 chr22:36424481 RBM9 0.62 7.34 0.41 2.61e-12 Gut microbiome composition (summer); CESC cis rs11608355 0.545 rs9943724 chr12:109902903 G/A cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.83e-17 Neuroticism; CESC cis rs6942756 1.000 rs12111832 chr7:128889025 G/C cg02491457 chr7:128862824 NA -0.69 -9.82 -0.52 1.29e-19 White matter hyperintensity burden; CESC cis rs9314323 0.767 rs1865305 chr8:26233325 G/A cg11498726 chr8:26250323 BNIP3L -0.44 -6.36 -0.36 8.62e-10 Red cell distribution width; CESC cis rs4604732 0.527 rs7539082 chr1:247627260 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.37 0.36 8.49e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9549260 0.755 rs8001443 chr13:41216646 C/T cg21288729 chr13:41239152 FOXO1 -0.69 -8.87 -0.48 1.08e-16 Red blood cell count; CESC cis rs748404 0.560 rs529611 chr15:43805988 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.49 7.29 0.41 3.47e-12 Lung cancer; CESC cis rs4974559 0.501 rs900013 chr4:1240450 G/A cg02980000 chr4:1222292 CTBP1 -0.76 -7.88 -0.44 8.61e-14 Systolic blood pressure; CESC cis rs6963495 0.769 rs11556986 chr7:105177041 A/T cg19920283 chr7:105172520 RINT1 0.76 7.88 0.44 8.75e-14 Bipolar disorder (body mass index interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02955050 chr19:59070391 UBE2M;LOC100131691 -0.51 -7.27 -0.41 4.16e-12 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01933576 chr16:15083564 PDXDC1 -0.61 -6.79 -0.38 7.51e-11 Gut microbiome composition (summer); CESC trans rs2018683 0.770 rs10951208 chr7:29022504 G/T cg19402173 chr7:128379420 CALU -0.6 -7.48 -0.42 1.13e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 7.08 0.4 1.26e-11 Personality dimensions; CESC cis rs9815354 1.000 rs1613759 chr3:41906183 G/A cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7336332 0.800 rs9805452 chr13:28047908 C/T cg01674679 chr13:27998804 GTF3A -0.46 -5.05 -0.3 8.37e-7 Weight; CESC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg06634786 chr22:41940651 POLR3H 0.68 6.78 0.38 7.6e-11 Vitiligo; CESC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg12463550 chr7:65579703 CRCP -0.52 -6.76 -0.38 8.97e-11 Aortic root size; CESC cis rs12142240 0.698 rs67941619 chr1:46838219 A/G cg00530320 chr1:46809349 NSUN4 0.6 7.92 0.44 6.39e-14 Menopause (age at onset); CESC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg19592336 chr6:28129416 ZNF389 0.51 6.88 0.39 4.26e-11 Depression; CESC cis rs731174 0.959 rs7546741 chr1:38191397 G/C cg06917450 chr1:38156652 C1orf109 -0.44 -5.45 -0.32 1.17e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs55823223 0.564 rs936391 chr17:73847799 A/G cg02397686 chr17:73851076 WBP2 -0.48 -6.44 -0.37 5.54e-10 Psoriasis; CESC cis rs250677 1.000 rs36079 chr5:148430504 G/A cg18129178 chr5:148520854 ABLIM3 -0.45 -5.31 -0.31 2.31e-7 Breast cancer; CESC trans rs1814175 0.645 rs7952104 chr11:49964180 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg03452623 chr4:187889614 NA -0.88 -16.31 -0.71 7.08e-42 Lobe attachment (rater-scored or self-reported); CESC cis rs13102973 0.640 rs4864245 chr4:135882847 G/C cg14419869 chr4:135874104 NA -0.35 -5.03 -0.3 8.86e-7 Subjective well-being; CESC cis rs4588572 0.570 rs2362832 chr5:77795843 A/G cg11547950 chr5:77652471 NA -0.45 -5.72 -0.33 2.92e-8 Triglycerides; CESC trans rs629535 0.783 rs538832 chr8:70033817 A/G cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg18446336 chr7:2847575 GNA12 -0.34 -5.08 -0.3 7.23e-7 Height; CESC cis rs2279817 0.820 rs924686 chr1:18027726 C/A cg21791023 chr1:18019539 ARHGEF10L 0.55 8.03 0.44 3.12e-14 Neuroticism; CESC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 13.14 0.63 1.06e-30 Personality dimensions; CESC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg11764359 chr7:65958608 NA -0.79 -11.87 -0.59 2.42e-26 Aortic root size; CESC cis rs6957923 0.655 rs13241000 chr7:23588135 A/G cg20265043 chr7:23510089 IGF2BP3 0.41 5.12 0.3 5.83e-7 Height; CESC cis rs12530845 0.623 rs73721669 chr7:135347107 C/G cg23117316 chr7:135346802 PL-5283 -0.59 -6.4 -0.37 6.93e-10 Red blood cell traits; CESC cis rs1322639 0.614 rs6925188 chr6:169563337 T/C cg03254818 chr6:169586852 NA 0.5 5.32 0.31 2.2e-7 Pulse pressure; CESC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg06873352 chr17:61820015 STRADA -0.66 -11.43 -0.57 7.58e-25 Prudent dietary pattern; CESC cis rs7236492 0.683 rs79747802 chr18:77198964 C/T cg15644404 chr18:77186268 NFATC1 -0.69 -5.4 -0.31 1.49e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs4808199 1.000 rs12972397 chr19:19562349 G/A cg03709012 chr19:19516395 GATAD2A 1.13 13.2 0.63 6.29e-31 Nonalcoholic fatty liver disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13265914 chr8:21999630 REEP4 -0.46 -6.72 -0.38 1.14e-10 Gambling; CESC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.69 -7.9 -0.44 7.36e-14 Gut microbiome composition (summer); CESC cis rs9488822 0.636 rs6937104 chr6:116375302 A/G cg26893134 chr6:116381904 FRK 0.25 6.16 0.35 2.67e-9 Cholesterol, total;LDL cholesterol; CESC cis rs6912958 0.874 rs9294381 chr6:88152681 A/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -5.36 -0.31 1.81e-7 Monocyte percentage of white cells; CESC cis rs1538970 0.962 rs7544178 chr1:45819069 C/T cg06784218 chr1:46089804 CCDC17 0.31 5.16 0.3 4.94e-7 Platelet count; CESC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg21433313 chr16:3507492 NAT15 -0.48 -7.66 -0.43 3.51e-13 Tuberculosis; CESC cis rs4555082 0.915 rs79048296 chr14:105754944 G/A cg27165867 chr14:105738592 BRF1 -0.49 -5.22 -0.31 3.63e-7 Mean platelet volume;Platelet distribution width; CESC cis rs12477438 0.765 rs10181422 chr2:99558970 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.84 -0.48 1.33e-16 Chronic sinus infection; CESC cis rs7949030 0.504 rs2516633 chr11:62371773 A/C cg22862634 chr11:62369728 EML3;MTA2 -0.43 -5.72 -0.33 2.94e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6121246 0.954 rs6060989 chr20:30429763 C/T cg13852791 chr20:30311386 BCL2L1 0.75 7.48 0.42 1.09e-12 Mean corpuscular hemoglobin; CESC cis rs796364 0.806 rs79333757 chr2:200915716 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15650240 chr1:15736530 EFHD2 -0.47 -6.14 -0.35 2.93e-9 Ulcerative colitis; CESC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg18876405 chr7:65276391 NA -0.45 -6.2 -0.36 2.15e-9 Aortic root size; CESC cis rs2735413 0.846 rs12923290 chr16:78079956 A/G cg04733911 chr16:78082701 NA -0.53 -9.05 -0.49 3.19e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs11792861 0.888 rs57314245 chr9:111813832 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 7.02 0.4 1.89e-11 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03216991 chr17:2415620 METT10D 0.58 6.16 0.35 2.68e-9 Gut microbiome composition (summer); CESC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg02428538 chr16:24856791 SLC5A11 -0.6 -6.15 -0.35 2.78e-9 Intelligence (multi-trait analysis); CESC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -6.73 -0.38 1.07e-10 Bipolar disorder; CESC cis rs2635047 0.811 rs17723754 chr18:44771481 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 6.0 0.35 6.34e-9 Educational attainment; CESC trans rs3812049 0.826 rs34576922 chr5:127364103 C/G cg16011800 chr17:1958478 HIC1 0.53 6.17 0.35 2.55e-9 Lymphocyte counts;Red cell distribution width; CESC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.62 8.38 0.46 3.1e-15 Menopause (age at onset); CESC cis rs6582630 0.599 rs12824838 chr12:38373584 G/T cg26384229 chr12:38710491 ALG10B -0.49 -6.77 -0.38 8.39e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg11987759 chr7:65425863 GUSB -0.47 -6.42 -0.37 6.18e-10 Aortic root size; CESC cis rs8141529 0.748 rs5762882 chr22:29290680 C/A cg15103426 chr22:29168792 CCDC117 0.6 7.75 0.43 1.97e-13 Lymphocyte counts; CESC cis rs959260 0.765 rs12945469 chr17:73372243 G/A cg12999837 chr17:73267436 MIF4GD -0.51 -5.78 -0.33 2.1e-8 Systemic lupus erythematosus; CESC cis rs7223966 1.000 rs56383601 chr17:61929968 A/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.47 -5.35 -0.31 1.9e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs763014 0.865 rs4006748 chr16:632225 T/C cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg13628971 chr7:2884303 GNA12 0.4 5.35 0.31 1.87e-7 Height; CESC cis rs2880765 0.566 rs17553790 chr15:86013665 C/T cg10818794 chr15:86012489 AKAP13 0.38 5.25 0.31 3.2e-7 Coronary artery disease; CESC cis rs1215050 0.791 rs165252 chr4:98758728 A/C cg05340658 chr4:99064831 C4orf37 0.51 6.64 0.38 1.8e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg16606324 chr3:10149918 C3orf24 0.42 5.19 0.3 4.26e-7 Alzheimer's disease; CESC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs1034435 0.547 rs6008741 chr22:48897881 G/A cg05992904 chr22:48892994 FAM19A5 -0.46 -6.61 -0.38 2.15e-10 Late-onset Alzheimer's disease; CESC cis rs12142240 0.698 rs68083747 chr1:46807416 T/G cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs9660992 0.512 rs12142402 chr1:205128215 A/T cg00857998 chr1:205179979 DSTYK 0.56 7.14 0.4 9.03e-12 Mean corpuscular volume;Mean platelet volume; CESC trans rs9929218 0.861 rs8056206 chr16:68802072 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.45 -0.46 1.96e-15 Colorectal cancer; CESC cis rs4812048 0.793 rs62205397 chr20:57597011 C/T cg14073986 chr20:57617431 SLMO2 0.7 5.9 0.34 1.09e-8 Mean platelet volume; CESC cis rs71403859 0.554 rs12920245 chr16:72029069 C/A cg08717414 chr16:71523259 ZNF19 -0.75 -5.11 -0.3 6.23e-7 Post bronchodilator FEV1; CESC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg14983838 chr19:29218262 NA 0.51 6.13 0.35 3.09e-9 Methadone dose in opioid dependence; CESC cis rs453301 0.507 rs2929306 chr8:9084909 C/T cg17143192 chr8:8559678 CLDN23 -0.47 -5.78 -0.33 2.13e-8 Joint mobility (Beighton score); CESC cis rs17818399 0.547 rs4953400 chr2:46777208 T/A cg06386533 chr2:46925753 SOCS5 0.44 5.1 0.3 6.54e-7 Height; CESC cis rs763121 0.853 rs35565791 chr22:39063011 C/A cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.58e-7 Menopause (age at onset); CESC cis rs9513593 1.000 rs1964898 chr13:99997181 A/G cg21788972 chr13:99853209 UBAC2 0.63 7.12 0.4 9.89e-12 Psoriasis; CESC cis rs3740540 0.507 rs2362500 chr10:126290431 T/C cg04949429 chr10:126290192 LHPP 0.39 5.46 0.32 1.11e-7 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs290268 0.669 rs10448310 chr9:93556174 A/G cg02608019 chr9:93564028 SYK 0.45 6.49 0.37 4.16e-10 Platelet count; CESC cis rs12900413 0.687 rs12911126 chr15:90315380 T/C cg24249390 chr15:90295951 MESP1 -0.39 -5.34 -0.31 1.99e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.14 -0.3 5.22e-7 Lung cancer; CESC cis rs1882538 0.538 rs7783217 chr7:133104117 C/G cg10665199 chr7:133106180 EXOC4 -0.57 -7.67 -0.43 3.21e-13 Intelligence (multi-trait analysis); CESC cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg09060608 chr5:178986726 RUFY1 0.51 7.79 0.43 1.5700000000000001e-13 Lung cancer; CESC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.38 0.31 1.66e-7 Tonsillectomy; CESC cis rs3741798 0.614 rs61922044 chr12:12490914 G/A cg08615371 chr12:12503544 MANSC1 0.94 6.58 0.37 2.54e-10 Cerebrospinal fluid biomarker levels; CESC cis rs9486719 0.901 rs760619 chr6:96857431 A/G cg06623918 chr6:96969491 KIAA0776 0.82 8.03 0.44 3.28e-14 Migraine;Coronary artery disease; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg17850538 chr15:35280322 ZNF770 0.51 6.48 0.37 4.33e-10 Retinol levels; CESC cis rs6460942 0.908 rs73677570 chr7:12280329 T/C cg06484146 chr7:12443880 VWDE -0.54 -5.77 -0.33 2.26e-8 Coronary artery disease; CESC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.5 -5.28 -0.31 2.67e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg11644478 chr21:40555479 PSMG1 -0.8 -11.96 -0.59 1.23e-26 Cognitive function; CESC cis rs3741151 1.000 rs3741149 chr11:73021084 A/G cg17517138 chr11:73019481 ARHGEF17 -0.59 -5.06 -0.3 7.67e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs9850225 0.666 rs1438565 chr3:81030149 T/C cg27138204 chr12:54446100 HOXC4 -0.37 -6.06 -0.35 4.76e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg24296786 chr1:45957014 TESK2 0.63 8.48 0.46 1.62e-15 High light scatter reticulocyte count; CESC cis rs6089584 0.507 rs28545731 chr20:60634102 C/T cg24733560 chr20:60626293 TAF4 0.45 6.63 0.38 1.83e-10 Body mass index; CESC cis rs4689388 0.750 rs10755148 chr4:6295064 A/G cg25554036 chr4:6271136 WFS1 0.48 6.96 0.39 2.6e-11 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9325144 0.647 rs35254764 chr12:39102928 T/C cg26384229 chr12:38710491 ALG10B -0.5 -7.06 -0.4 1.47e-11 Morning vs. evening chronotype; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg21235025 chr13:72249355 DACH1 -0.48 -6.96 -0.39 2.66e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11122272 0.603 rs2998427 chr1:231528112 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.79e-9 Hemoglobin concentration; CESC cis rs7809950 0.954 rs2520247 chr7:107143946 A/T cg23024343 chr7:107201750 COG5 -0.43 -6.08 -0.35 4.18e-9 Coronary artery disease; CESC cis rs7605827 0.897 rs10432400 chr2:15667324 T/C cg19274914 chr2:15703543 NA 0.33 5.76 0.33 2.28e-8 Educational attainment (years of education); CESC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -6.89 -0.39 4.16e-11 Developmental language disorder (linguistic errors); CESC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg21361702 chr7:150065534 REPIN1 0.52 5.34 0.31 2.05e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs12545109 0.800 rs1467126 chr8:57418452 C/T cg09654669 chr8:57350985 NA -0.45 -6.27 -0.36 1.47e-9 Obesity-related traits; CESC cis rs2073300 0.609 rs6132617 chr20:23420151 G/C cg16736954 chr20:23401023 NAPB 0.71 5.63 0.33 4.67e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2228479 0.850 rs2238527 chr16:89840708 C/A cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs4481887 0.927 rs4916087 chr1:248493833 T/C cg00666640 chr1:248458726 OR2T12 0.36 6.17 0.35 2.56e-9 Common traits (Other); CESC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg15147215 chr3:52552868 STAB1 -0.31 -5.24 -0.31 3.27e-7 Electroencephalogram traits; CESC cis rs2180341 1.000 rs7776136 chr6:127638348 A/T cg24812749 chr6:127587940 RNF146 1.08 15.58 0.69 2.77e-39 Breast cancer; CESC trans rs1814175 0.817 rs3974439 chr11:50022607 G/A cg03929089 chr4:120376271 NA -0.94 -16.01 -0.7 7.75e-41 Height; CESC cis rs9309473 0.528 rs6546820 chr2:73553397 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.39 -0.37 7.54e-10 Metabolite levels; CESC cis rs9309473 0.583 rs6713196 chr2:73576405 T/C cg20560298 chr2:73613845 ALMS1 -0.44 -5.97 -0.34 7.66e-9 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10626718 chr8:67687371 SGK3 0.56 6.13 0.35 3.13e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs55788414 0.932 rs12103358 chr16:81185844 C/G cg06400318 chr16:81190750 PKD1L2 -0.5 -6.08 -0.35 4.16e-9 Left ventricular obstructive tract defect (maternal effect); CESC cis rs4319547 0.695 rs10773103 chr12:122856532 A/G cg05707623 chr12:122985044 ZCCHC8 0.56 6.3 0.36 1.2e-9 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27432331 chr16:30544242 ZNF747 -0.57 -6.41 -0.37 6.62e-10 Gut microbiome composition (summer); CESC cis rs8070624 0.543 rs7219320 chr17:17880877 A/G cg16928487 chr17:17741425 SREBF1 -0.61 -10.21 -0.53 7.35e-21 Total body bone mineral density; CESC cis rs8111998 0.702 rs16999400 chr19:22768608 A/G cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs561341 0.714 rs55925849 chr17:30253085 C/T cg19193384 chr17:30244184 NA -0.7 -6.41 -0.37 6.77e-10 Hip circumference adjusted for BMI; CESC cis rs804280 0.565 rs1466785 chr8:11623456 C/T cg12395012 chr8:11607386 GATA4 -0.45 -6.38 -0.36 7.96e-10 Myopia (pathological); CESC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg08027265 chr7:2291960 NA -0.48 -7.45 -0.42 1.31e-12 Schizophrenia, schizoaffective disorder or bipolar disorder; CESC cis rs116095464 0.510 rs60844864 chr5:267000 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.35 -0.46 3.92e-15 Breast cancer; CESC trans rs11098499 0.863 rs11731756 chr4:120478696 T/G cg25214090 chr10:38739885 LOC399744 0.66 9.03 0.49 3.57e-17 Corneal astigmatism; CESC cis rs4969178 0.965 rs12450528 chr17:76395753 G/A cg05887092 chr17:76393375 PGS1 0.58 9.22 0.49 9.9e-18 HDL cholesterol levels; CESC cis rs1538970 0.924 rs1007858 chr1:45912005 C/T cg24296786 chr1:45957014 TESK2 -0.46 -5.25 -0.31 3.14e-7 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17727855 chr9:108007124 SLC44A1 0.61 6.56 0.37 2.82e-10 Gut microbiome composition (summer); CESC cis rs11997175 0.603 rs12156112 chr8:33791598 T/C ch.8.33884649F chr8:33765107 NA 0.47 5.55 0.32 6.87e-8 Body mass index; CESC cis rs8017423 0.967 rs2401875 chr14:90688451 A/G cg14092571 chr14:90743983 NA -0.56 -8.24 -0.45 7.77e-15 Mortality in heart failure; CESC cis rs727505 0.954 rs67870530 chr7:124591878 A/G cg23710748 chr7:124431027 NA -0.46 -7.28 -0.41 3.87e-12 Lewy body disease; CESC cis rs752010 0.756 rs6600380 chr1:42054814 C/T cg06885757 chr1:42089581 HIVEP3 -0.41 -6.68 -0.38 1.44e-10 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg21770322 chr7:97807741 LMTK2 0.57 8.71 0.47 3.45e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs7178572 0.539 rs12594346 chr15:77671966 A/T cg22256960 chr15:77711686 NA 0.48 5.39 0.31 1.53e-7 Type 2 diabetes; CESC cis rs61931739 0.500 rs11053251 chr12:34520743 A/G cg06521331 chr12:34319734 NA -0.37 -5.09 -0.3 6.85e-7 Morning vs. evening chronotype; CESC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg21285383 chr16:89894308 SPIRE2 0.31 5.6 0.33 5.34e-8 Vitiligo; CESC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg21926612 chr6:163149169 PACRG;PARK2 1.07 10.98 0.56 2.38e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11785400 0.793 rs4587307 chr8:143738529 G/A cg24634471 chr8:143751801 JRK 0.46 5.91 0.34 1.06e-8 Schizophrenia; CESC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.81 0.39 6.45e-11 Bipolar disorder; CESC cis rs7084402 0.565 rs1982173 chr10:60334002 G/T cg07615347 chr10:60278583 BICC1 0.41 6.0 0.35 6.44e-9 Refractive error; CESC cis rs7084402 1.000 rs12257983 chr10:60266555 A/C cg07615347 chr10:60278583 BICC1 -0.58 -8.92 -0.48 8.11e-17 Refractive error; CESC trans rs877282 0.945 rs10904554 chr10:786768 T/C cg22713356 chr15:30763199 NA 1.31 13.31 0.63 2.78e-31 Uric acid levels; CESC cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg23711669 chr6:146136114 FBXO30 1.02 16.0 0.7 8.93e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs12545109 0.879 rs7845180 chr8:57324431 C/T cg09654669 chr8:57350985 NA 0.51 6.3 0.36 1.21e-9 Obesity-related traits; CESC cis rs2072499 1.000 rs2540173 chr1:156188214 A/G cg25208724 chr1:156163844 SLC25A44 0.99 17.59 0.73 2.02e-46 Testicular germ cell tumor; CESC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg05368731 chr17:41323189 NBR1 0.8 11.32 0.57 1.66e-24 Menopause (age at onset); CESC cis rs9487051 0.698 rs35849756 chr6:109644610 G/A cg01475377 chr6:109611718 NA -0.39 -5.14 -0.3 5.41e-7 Reticulocyte fraction of red cells; CESC cis rs2439831 0.681 rs1095386 chr15:43609509 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.86 12.9 0.62 7.3e-30 Lung cancer in ever smokers; CESC cis rs9362426 1.000 rs173334 chr6:88080223 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.48 6.04 0.35 5.08e-9 Depressive episodes in bipolar disorder; CESC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg11764359 chr7:65958608 NA -0.79 -11.32 -0.57 1.67e-24 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06231882 chr16:81040594 CENPN;C16orf61 -0.44 -6.09 -0.35 3.89e-9 Gambling; CESC trans rs1814175 0.717 rs11040450 chr11:49650638 G/A cg03929089 chr4:120376271 NA -0.87 -13.23 -0.63 4.97e-31 Height; CESC cis rs11587400 0.572 rs2268699 chr1:115227896 G/T cg12756093 chr1:115239321 AMPD1 0.52 7.36 0.41 2.38e-12 Autism; CESC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg16325326 chr1:53192061 ZYG11B -0.88 -15.06 -0.68 1.8e-37 Monocyte count; CESC cis rs9302635 0.745 rs35909200 chr16:72156666 T/G cg01557791 chr16:72042693 DHODH -0.6 -5.46 -0.32 1.09e-7 Blood protein levels; CESC cis rs2742234 0.955 rs2075913 chr10:43622368 T/A cg07801480 chr10:43725741 RASGEF1A 0.38 5.49 0.32 9.27e-8 Hirschsprung disease; CESC cis rs965513 0.627 rs7848973 chr9:100588839 A/G cg13688889 chr9:100608707 NA -0.52 -7.72 -0.43 2.46e-13 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg19717773 chr7:2847554 GNA12 -0.52 -8.18 -0.45 1.22e-14 Height; CESC cis rs8013055 0.846 rs10136015 chr14:105973469 A/C cg23356831 chr14:105996513 TMEM121 0.37 5.14 0.3 5.23e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC cis rs477692 1.000 rs558764 chr10:131426957 G/T cg05714579 chr10:131428358 MGMT -0.47 -6.44 -0.37 5.63e-10 Response to temozolomide; CESC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs61931739 0.736 rs7314457 chr12:34454301 G/A cg19457237 chr12:34500585 NA -0.35 -5.15 -0.3 5.05e-7 Morning vs. evening chronotype; CESC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs9486715 0.867 rs4839842 chr6:96955387 A/T cg18709589 chr6:96969512 KIAA0776 0.46 6.48 0.37 4.41e-10 Headache; CESC cis rs5758659 1.000 rs134900 chr22:42683343 C/G cg04733989 chr22:42467013 NAGA 0.42 5.98 0.34 7.15e-9 Cognitive function; CESC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg24634471 chr8:143751801 JRK -0.47 -5.14 -0.3 5.47e-7 Urinary tract infection frequency; CESC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg22800045 chr5:56110881 MAP3K1 -0.82 -10.17 -0.53 9.98e-21 Initial pursuit acceleration; CESC cis rs372883 0.600 rs407712 chr21:30722531 G/A cg24692254 chr21:30365293 RNF160 -0.59 -7.4 -0.41 1.75e-12 Pancreatic cancer; CESC cis rs4862750 0.872 rs7664463 chr4:187876686 A/C cg27532560 chr4:187881888 NA -0.36 -5.46 -0.32 1.09e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.33 5.35 0.31 1.88e-7 Monocyte percentage of white cells; CESC cis rs9902453 0.704 rs2617874 chr17:28085172 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.18 0.45 1.22e-14 Coffee consumption (cups per day); CESC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg05340658 chr4:99064831 C4orf37 0.83 12.91 0.62 6.62e-30 Colonoscopy-negative controls vs population controls; CESC trans rs208520 0.661 rs207111 chr6:66792513 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.83 -0.62 1.2e-29 Exhaled nitric oxide output; CESC cis rs8017423 0.967 rs7160032 chr14:90708472 A/G cg14092571 chr14:90743983 NA -0.56 -8.31 -0.45 4.95e-15 Mortality in heart failure; CESC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg04518342 chr5:131593106 PDLIM4 0.4 5.96 0.34 8.2e-9 Breast cancer; CESC cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.71 8.4 0.46 2.77e-15 Age-related macular degeneration (geographic atrophy); CESC cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg26516362 chr5:178986906 RUFY1 0.41 6.02 0.35 5.78e-9 Lung cancer; CESC cis rs4805272 0.512 rs8105613 chr19:29339151 C/T cg12756686 chr19:29218302 NA 0.41 5.36 0.31 1.78e-7 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs2688608 0.592 rs12253482 chr10:75496130 G/A cg23231163 chr10:75533350 FUT11 -0.36 -5.53 -0.32 7.68e-8 Inflammatory bowel disease; CESC cis rs10911251 0.528 rs4652777 chr1:183091992 T/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Colorectal cancer; CESC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.59 0.64 2.72e-32 Prudent dietary pattern; CESC cis rs561341 0.943 rs508566 chr17:30289861 G/C cg19193384 chr17:30244184 NA -0.72 -6.61 -0.38 2.11e-10 Hip circumference adjusted for BMI; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04251662 chr3:4535075 ITPR1 -0.48 -6.14 -0.35 2.92e-9 Asthma; CESC cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg22467129 chr15:76604101 ETFA -0.39 -6.03 -0.35 5.57e-9 Blood metabolite levels; CESC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg22963979 chr7:1858916 MAD1L1 -0.37 -5.06 -0.3 7.72e-7 Autism spectrum disorder or schizophrenia; CESC cis rs72634258 0.519 rs4908713 chr1:7946831 G/A cg00042356 chr1:8021962 PARK7 0.57 5.27 0.31 2.84e-7 Inflammatory bowel disease; CESC cis rs2455799 0.573 rs2654650 chr3:15779214 C/T cg09340198 chr3:15902540 ANKRD28 -0.33 -5.16 -0.3 4.81e-7 Mean platelet volume; CESC cis rs965469 1.000 rs2236118 chr20:3302058 C/T cg25506879 chr20:3388711 C20orf194 -0.55 -5.9 -0.34 1.08e-8 IFN-related cytopenia; CESC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg07153921 chr17:41440717 NA -0.4 -5.29 -0.31 2.58e-7 Menopause (age at onset); CESC cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg18490616 chr2:88469792 THNSL2 -0.52 -7.61 -0.42 4.92e-13 Response to metformin (IC50); CESC cis rs4563143 0.514 rs55727361 chr19:29300415 A/T cg04546413 chr19:29218101 NA 0.48 5.97 0.34 7.4e-9 Methadone dose in opioid dependence; CESC cis rs8050907 0.744 rs7195782 chr16:4539861 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.89 6.22 0.36 1.94e-9 Obesity-related traits; CESC cis rs9915657 0.840 rs10512582 chr17:70139393 A/C cg06234051 chr17:70120541 SOX9 -0.44 -6.65 -0.38 1.67e-10 Thyroid hormone levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06361278 chr17:25783929 NA 0.53 6.19 0.36 2.27e-9 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26354882 chr1:167691290 MPZL1 -0.48 -6.11 -0.35 3.51e-9 Ulcerative colitis; CESC cis rs10028773 0.700 rs7690338 chr4:120256468 C/G cg09307838 chr4:120376055 NA 0.81 10.94 0.56 3.14e-23 Educational attainment; CESC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg26338869 chr17:61819248 STRADA 0.71 9.63 0.51 5.01e-19 Prudent dietary pattern; CESC cis rs992157 0.835 rs12987180 chr2:219144089 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.67 -8.69 -0.47 3.72e-16 Colorectal cancer; CESC cis rs10870270 0.956 rs10781555 chr10:133745720 G/A cg17892150 chr10:133769511 PPP2R2D -0.86 -12.61 -0.61 6.93e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs67311347 1.000 rs9829800 chr3:40443927 T/C cg09455208 chr3:40491958 NA 0.46 7.71 0.43 2.48e-13 Renal cell carcinoma; CESC cis rs1707322 0.752 rs6658700 chr1:46160260 C/T cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg21782813 chr7:2030301 MAD1L1 0.49 6.99 0.39 2.26e-11 Bipolar disorder and schizophrenia; CESC cis rs8070128 0.583 rs7406982 chr17:17942613 C/T cg16928487 chr17:17741425 SREBF1 -0.55 -9.13 -0.49 1.86e-17 Total body bone mineral density; CESC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg13607699 chr17:42295918 UBTF 0.62 8.37 0.46 3.46e-15 Total body bone mineral density; CESC cis rs12368653 0.840 rs3816896 chr12:58195773 C/T cg00677455 chr12:58241039 CTDSP2 -0.47 -6.24 -0.36 1.71e-9 Multiple sclerosis; CESC cis rs977987 0.800 rs12922951 chr16:75355096 C/G cg03315344 chr16:75512273 CHST6 0.39 5.59 0.32 5.55e-8 Dupuytren's disease; CESC cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg13880726 chr7:1868755 MAD1L1 -0.48 -5.08 -0.3 7.17e-7 Bipolar disorder; CESC cis rs7044106 0.762 rs10984974 chr9:123421556 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.77 0.33 2.18e-8 Hip circumference adjusted for BMI; CESC cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg23601416 chr22:19950040 COMT 0.27 5.09 0.3 6.85e-7 Blood metabolite levels; CESC trans rs9858542 0.953 rs9827021 chr3:49514764 C/A cg21659725 chr3:3221576 CRBN -0.54 -6.37 -0.36 8.2e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg04369109 chr6:150039330 LATS1 -0.4 -5.34 -0.31 2e-7 Lung cancer; CESC cis rs9467711 0.659 rs35555795 chr6:26509382 C/T cg21479132 chr6:26055353 NA 0.78 5.36 0.31 1.84e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7786877 0.582 rs2075674 chr7:100225031 G/A cg16850897 chr7:100343110 ZAN -0.62 -6.63 -0.38 1.9e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23679085 chr3:183892773 AP2M1 -0.47 -6.83 -0.39 5.91e-11 Gambling; CESC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg23758822 chr17:41437982 NA 1.02 15.6 0.69 2.35e-39 Menopause (age at onset); CESC cis rs7666738 0.546 rs7699578 chr4:98838893 T/C cg17366294 chr4:99064904 C4orf37 0.5 5.35 0.31 1.87e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg05234568 chr11:5960015 NA -0.63 -7.53 -0.42 8.12e-13 DNA methylation (variation); CESC cis rs7727544 0.660 rs272886 chr5:131665840 T/C cg07395648 chr5:131743802 NA -0.5 -6.56 -0.37 2.8e-10 Blood metabolite levels; CESC cis rs8114671 0.562 rs1013677 chr20:33468793 C/T cg06115741 chr20:33292138 TP53INP2 0.43 5.46 0.32 1.11e-7 Height; CESC cis rs6963495 0.818 rs73192105 chr7:105167945 T/C cg13798780 chr7:105162888 PUS7 0.77 7.87 0.44 9.18e-14 Bipolar disorder (body mass index interaction); CESC cis rs4595586 0.545 rs12812762 chr12:39371141 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.51 0.42 8.86e-13 Morning vs. evening chronotype; CESC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg25036284 chr2:26402008 FAM59B 0.86 9.36 0.5 3.44e-18 Gut microbiome composition (summer); CESC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg11890956 chr21:40555474 PSMG1 -0.61 -8.41 -0.46 2.6e-15 Menarche (age at onset); CESC cis rs2455799 0.573 rs2455831 chr3:15751583 T/A cg16303742 chr3:15540471 COLQ -0.35 -5.38 -0.31 1.61e-7 Mean platelet volume; CESC cis rs2204008 0.806 rs1589382 chr12:38408565 T/A cg13010199 chr12:38710504 ALG10B 0.46 5.98 0.35 7.04e-9 Bladder cancer; CESC cis rs9329289 0.926 rs9329290 chr10:2542751 G/T cg15501526 chr10:2543763 NA 0.65 11.89 0.59 2.1e-26 Age-related hearing impairment; CESC cis rs7917772 0.636 rs7088981 chr10:104520423 T/C cg04362960 chr10:104952993 NT5C2 0.46 5.27 0.31 2.86e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs8078723 1.000 rs6503530 chr17:38161823 T/C cg17467752 chr17:38218738 THRA 0.69 10.55 0.54 5.78e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs11153306 0.677 rs10872070 chr6:111921804 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.4 -5.8 -0.34 1.91e-8 Tonsillectomy; CESC cis rs6121246 0.779 rs6060763 chr20:30282223 A/G cg13852791 chr20:30311386 BCL2L1 0.76 8.37 0.46 3.36e-15 Mean corpuscular hemoglobin; CESC cis rs804280 0.525 rs17153755 chr8:11611500 C/G cg12395012 chr8:11607386 GATA4 -0.48 -7.13 -0.4 9.84e-12 Myopia (pathological); CESC cis rs863345 0.604 rs12122663 chr1:158506724 A/G cg12129480 chr1:158549410 OR10X1 -0.34 -6.82 -0.39 6.1e-11 Pneumococcal bacteremia; CESC cis rs7618501 0.722 rs9853458 chr3:49783211 A/C cg24308560 chr3:49941425 MST1R 0.49 6.74 0.38 9.66e-11 Intelligence (multi-trait analysis); CESC cis rs7786808 0.712 rs2335170 chr7:158207101 G/A cg01191920 chr7:158217561 PTPRN2 -0.36 -5.92 -0.34 9.94e-9 Obesity-related traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15813570 chr14:64854563 MTHFD1 0.47 6.24 0.36 1.72e-9 Gut microbiota (bacterial taxa); CESC trans rs9325144 0.555 rs10748433 chr12:38696352 C/G cg23762105 chr12:34175262 ALG10 -0.49 -6.56 -0.37 2.76e-10 Morning vs. evening chronotype; CESC cis rs7312933 1.000 rs7312933 chr12:42503467 C/T cg01256987 chr12:42539512 GXYLT1 0.34 5.09 0.3 6.78e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs57083693 0.518 rs6538982 chr12:101708103 T/C cg22051763 chr12:101673672 UTP20 -0.42 -5.28 -0.31 2.68e-7 Alcohol dependence (age at onset); CESC cis rs6570726 0.935 rs391820 chr6:145821284 C/T cg05347473 chr6:146136440 FBXO30 0.42 5.72 0.33 2.93e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs6142102 0.602 rs1054534 chr20:32605327 G/C cg08999081 chr20:33150536 PIGU 0.33 5.05 0.3 8.33e-7 Skin pigmentation; CESC cis rs4588572 0.673 rs9293745 chr5:77646075 G/A cg11547950 chr5:77652471 NA -0.4 -5.77 -0.33 2.19e-8 Triglycerides; CESC cis rs9287719 0.967 rs2010073 chr2:10736478 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs7474896 0.526 rs1208633 chr10:38156873 A/C cg25427524 chr10:38739819 LOC399744 0.51 5.87 0.34 1.3e-8 Obesity (extreme); CESC cis rs8077577 0.689 rs16961114 chr17:18215339 G/C cg16794390 chr17:18148240 FLII 0.41 6.48 0.37 4.41e-10 Obesity-related traits; CESC cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg19418458 chr7:158789849 NA 0.48 7.8 0.43 1.42e-13 Facial morphology (factor 20); CESC cis rs854765 0.583 rs11650649 chr17:17790319 C/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.53 -7.27 -0.41 4.14e-12 Total body bone mineral density; CESC cis rs2832191 0.935 rs67287920 chr21:30523519 C/A cg08807101 chr21:30365312 RNF160 -0.68 -9.43 -0.5 2.23e-18 Dental caries; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg04917391 chr4:40859259 APBB2 0.55 6.43 0.37 5.83e-10 Psoriatic arthritis; CESC cis rs9303401 0.659 rs9303399 chr17:56672309 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.04 12.9 0.62 6.96e-30 Cognitive test performance; CESC trans rs208520 1.000 rs12190316 chr6:66973365 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 7.86 0.43 9.45e-14 Exhaled nitric oxide output; CESC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg02569458 chr12:86230093 RASSF9 0.45 6.7 0.38 1.27e-10 Major depressive disorder; CESC cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg03676636 chr4:99064102 C4orf37 0.35 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7772486 0.790 rs2265469 chr6:146219049 T/C cg23711669 chr6:146136114 FBXO30 0.92 13.36 0.63 1.78e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs524023 1.000 rs559946 chr11:64358605 T/C cg07220939 chr11:64358617 SLC22A12 0.36 5.54 0.32 7.2e-8 Urate levels in obese individuals; CESC cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg24920358 chr1:40204285 PPIE 0.43 6.4 0.37 7.07e-10 Blood protein levels; CESC cis rs57244997 1.000 rs73026573 chr6:162405119 C/T cg17173639 chr6:162384350 PARK2 -0.79 -7.93 -0.44 5.96e-14 Mosquito bite size; CESC cis rs644799 0.623 rs17207890 chr11:95490754 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.56 0.37 2.78e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs17376456 0.877 rs9314093 chr5:93333347 G/A cg21475434 chr5:93447410 FAM172A 0.78 6.94 0.39 3.03e-11 Diabetic retinopathy; CESC trans rs1476587 0.920 rs55657695 chr7:86734709 G/T cg09114546 chr16:70099078 PDXDC2 0.59 6.12 0.35 3.41e-9 Brachial circumference; CESC cis rs924607 0.583 rs12516251 chr5:608939 C/T cg07001201 chr5:642380 CEP72 0.55 7.75 0.43 2e-13 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9814567 1.000 rs9989967 chr3:134238964 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.82 -0.34 1.69e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs73206853 0.563 rs4073472 chr12:111176494 A/G cg12870014 chr12:110450643 ANKRD13A 0.73 5.39 0.31 1.53e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs12142240 0.731 rs6658556 chr1:46844180 A/C cg00530320 chr1:46809349 NSUN4 0.62 8.36 0.46 3.52e-15 Menopause (age at onset); CESC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg08027265 chr7:2291960 NA -0.34 -5.17 -0.3 4.57e-7 Bipolar disorder and schizophrenia; CESC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.93 0.34 9.63e-9 Tonsillectomy; CESC cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg24130564 chr14:104152367 KLC1 -0.49 -6.53 -0.37 3.28e-10 Reticulocyte count; CESC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.67 0.64 1.5e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9393777 0.513 rs9379893 chr6:26584668 A/G cg12292205 chr6:26970375 C6orf41 0.45 5.12 0.3 5.92e-7 Intelligence (multi-trait analysis); CESC cis rs3733585 0.699 rs6856127 chr4:9965443 T/C cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.66e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg05863683 chr7:1912471 MAD1L1 0.5 7.71 0.43 2.62e-13 Bipolar disorder and schizophrenia; CESC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg11764359 chr7:65958608 NA -0.94 -14.21 -0.66 1.83e-34 Aortic root size; CESC cis rs11792861 0.781 rs838835 chr9:111758590 A/G cg05043794 chr9:111880884 C9orf5 0.37 6.32 0.36 1.08e-9 Menarche (age at onset); CESC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg21782813 chr7:2030301 MAD1L1 0.49 6.98 0.39 2.31e-11 Schizophrenia; CESC cis rs7429990 0.901 rs7433678 chr3:48037078 G/A cg11946769 chr3:48343235 NME6 -0.43 -5.22 -0.31 3.62e-7 Educational attainment (years of education); CESC cis rs2439831 0.717 rs9806227 chr15:43680115 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.86 13.04 0.63 2.26e-30 Lung cancer in ever smokers; CESC cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg11266682 chr4:10021025 SLC2A9 0.65 12.92 0.62 5.96e-30 Bone mineral density; CESC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg26338869 chr17:61819248 STRADA 0.69 9.18 0.49 1.31e-17 Prudent dietary pattern; CESC cis rs11098499 0.863 rs3775841 chr4:120425777 A/C cg09307838 chr4:120376055 NA 0.95 13.0 0.62 3.29e-30 Corneal astigmatism; CESC cis rs939658 0.805 rs34478496 chr15:79440997 C/A cg17916960 chr15:79447300 NA -0.35 -5.98 -0.34 7.25e-9 Refractive error; CESC cis rs3820068 0.581 rs72645879 chr1:15928199 A/G cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs4808199 0.649 rs34755166 chr19:19665581 G/A cg03709012 chr19:19516395 GATAD2A 0.98 8.36 0.46 3.61e-15 Nonalcoholic fatty liver disease; CESC cis rs763014 0.931 rs56048717 chr16:634867 A/G cg07343612 chr16:622815 PIGQ -0.55 -8.06 -0.44 2.55e-14 Height; CESC trans rs10506458 0.834 rs58821476 chr12:63389425 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -17.85 -0.74 2.4e-47 Hemostatic factors and hematological phenotypes; CESC cis rs854765 0.964 rs854762 chr17:18009102 G/A cg16928487 chr17:17741425 SREBF1 0.58 9.6 0.51 6.17e-19 Total body bone mineral density; CESC cis rs4953076 0.574 rs4953074 chr2:44464629 C/T cg04920474 chr2:44395004 PPM1B 0.54 7.07 0.4 1.38e-11 Height; CESC cis rs9287719 0.967 rs12464908 chr2:10761496 T/G cg00105475 chr2:10696890 NA 0.38 5.37 0.31 1.7e-7 Prostate cancer; CESC cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6964587 0.869 rs10241720 chr7:91527367 G/T cg17063962 chr7:91808500 NA -0.54 -7.24 -0.41 4.76e-12 Breast cancer; CESC cis rs4268898 0.662 rs72795824 chr2:24435837 T/C cg08917208 chr2:24149416 ATAD2B 0.55 5.27 0.31 2.89e-7 Asthma; CESC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg05368731 chr17:41323189 NBR1 0.8 11.32 0.57 1.66e-24 Menopause (age at onset); CESC cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg02773041 chr1:40204384 PPIE 0.52 7.3 0.41 3.29e-12 Blood protein levels; CESC cis rs9790314 0.690 rs7617204 chr3:160821969 A/G cg03342759 chr3:160939853 NMD3 -0.45 -5.9 -0.34 1.12e-8 Morning vs. evening chronotype; CESC cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg22467129 chr15:76604101 ETFA -0.38 -5.67 -0.33 3.64e-8 Blood metabolite levels; CESC cis rs863345 0.967 rs11264990 chr1:158469359 T/C cg12129480 chr1:158549410 OR10X1 -0.31 -6.19 -0.36 2.34e-9 Pneumococcal bacteremia; CESC cis rs75477785 1.000 rs77037440 chr1:209985136 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg19193384 chr17:30244184 NA -0.54 -5.93 -0.34 9.62e-9 Hip circumference adjusted for BMI; CESC cis rs7568498 0.564 rs10490563 chr2:161914168 G/A cg21518248 chr2:162101506 NA -0.49 -5.34 -0.31 2.02e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12909921 chr17:37558512 FBXL20 -0.46 -6.71 -0.38 1.17e-10 Gambling; CESC cis rs3768617 0.811 rs12022720 chr1:183017223 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 8.79 0.48 1.91e-16 Fuchs's corneal dystrophy; CESC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs1670533 1.000 rs2045069 chr4:1052206 T/C cg27284194 chr4:1044797 NA 0.45 5.62 0.33 4.91e-8 Recombination rate (females); CESC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg24675658 chr1:53192096 ZYG11B -0.49 -6.16 -0.35 2.67e-9 Monocyte count; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg11814422 chr18:47018265 SNORD58A;RPL17;SNORD58B -0.46 -6.25 -0.36 1.66e-9 Height; CESC cis rs7584330 0.826 rs72620824 chr2:238381083 G/A cg14458575 chr2:238380390 NA 0.92 13.16 0.63 8.78e-31 Prostate cancer; CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg24739457 chr1:205821442 NA -0.45 -6.32 -0.36 1.09e-9 Monocyte percentage of white cells; CESC cis rs2404602 0.692 rs12594556 chr15:77165363 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.68 -0.33 3.63e-8 Blood metabolite levels; CESC cis rs7937682 0.855 rs527078 chr11:111479713 T/C cg09085632 chr11:111637200 PPP2R1B -0.92 -14.19 -0.66 2.29e-34 Primary sclerosing cholangitis; CESC cis rs72781680 1.000 rs56339200 chr2:24188194 C/A cg08917208 chr2:24149416 ATAD2B 0.94 8.54 0.46 1.09e-15 Lymphocyte counts; CESC cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg18180107 chr4:99064573 C4orf37 0.39 5.04 0.3 8.7e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3106136 0.967 rs282448 chr4:95141411 T/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.01 -0.4 1.94e-11 Capecitabine sensitivity; CESC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg18876405 chr7:65276391 NA 0.53 7.28 0.41 3.9e-12 Aortic root size; CESC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC trans rs561341 0.609 rs7214626 chr17:30190989 G/A cg20587970 chr11:113659929 NA 0.57 6.96 0.39 2.65e-11 Hip circumference adjusted for BMI; CESC cis rs453301 0.686 rs11785819 chr8:8870378 T/G cg15556689 chr8:8085844 FLJ10661 -0.48 -5.71 -0.33 2.97e-8 Joint mobility (Beighton score); CESC cis rs7084402 0.967 rs1649036 chr10:60331878 C/A cg07615347 chr10:60278583 BICC1 0.59 9.15 0.49 1.57e-17 Refractive error; CESC cis rs698813 0.851 rs786420 chr2:44719893 C/T cg04920474 chr2:44395004 PPM1B 0.4 5.09 0.3 6.83e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg21782813 chr7:2030301 MAD1L1 -0.36 -5.26 -0.31 2.92e-7 Bipolar disorder and schizophrenia; CESC cis rs829883 0.573 rs73136486 chr12:98913727 T/A cg25150519 chr12:98850993 NA -0.65 -7.95 -0.44 5.42e-14 Colorectal adenoma (advanced); CESC cis rs4253772 0.530 rs9615955 chr22:46743931 A/G cg24881330 chr22:46731750 TRMU 0.8 5.61 0.33 5.02e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9325144 0.647 rs35138700 chr12:38804474 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.5 -0.42 9.73e-13 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7246657 0.525 rs997516 chr19:37474264 T/C cg23950597 chr19:37808831 NA -0.51 -5.05 -0.3 8.18e-7 Coronary artery calcification; CESC cis rs7020830 0.861 rs13295981 chr9:37330067 C/T cg14294708 chr9:37120828 ZCCHC7 1.25 24.44 0.83 7.55e-70 Schizophrenia; CESC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.48 6.05 0.35 4.83e-9 Tonsillectomy; CESC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.16e-7 Aortic root size; CESC cis rs9640161 0.659 rs17837498 chr7:150009679 A/G cg21361702 chr7:150065534 REPIN1 0.54 6.29 0.36 1.3e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs7312933 1.000 rs12372623 chr12:42531666 G/A cg01256987 chr12:42539512 GXYLT1 -0.33 -5.11 -0.3 6.22e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs1451375 0.572 rs4948205 chr7:50557774 G/A cg14593290 chr7:50529359 DDC -0.5 -6.27 -0.36 1.47e-9 Malaria; CESC cis rs7084402 0.935 rs2393449 chr10:60343030 A/G cg07615347 chr10:60278583 BICC1 0.56 8.67 0.47 4.26e-16 Refractive error; CESC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 5.62 0.33 4.72e-8 Menopause (age at onset); CESC cis rs4728302 0.869 rs10155909 chr7:133593036 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.33 0.31 2.05e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7937 0.693 rs2279011 chr19:41269288 G/T cg09128733 chr19:41633906 CYP2F1 -0.36 -5.15 -0.3 5.04e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Chronic obstructive pulmonary disease;Emphysema imaging phenotypes; CESC cis rs854765 0.547 rs2955383 chr17:17941364 A/G cg16928487 chr17:17741425 SREBF1 -0.57 -9.8 -0.52 1.45e-19 Total body bone mineral density; CESC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg04267008 chr7:1944627 MAD1L1 -0.71 -9.09 -0.49 2.4e-17 Bipolar disorder and schizophrenia; CESC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg17724175 chr1:150552817 MCL1 0.38 5.96 0.34 8.07e-9 Melanoma; CESC cis rs634534 0.562 rs1151505 chr11:65734539 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.44 5.59 0.32 5.77e-8 Sum eosinophil basophil counts;Eosinophil counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10229899 chr1:49364797 AGBL4 -0.53 -6.39 -0.37 7.44e-10 Gut microbiome composition (summer); CESC cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 13.13 0.63 1.09e-30 Personality dimensions; CESC trans rs1814175 0.817 rs28594987 chr11:50045181 C/T cg15704280 chr7:45808275 SEPT13 -1.05 -20.97 -0.79 3.22e-58 Height; CESC cis rs6963495 0.818 rs73192143 chr7:105202415 A/G cg02135003 chr7:105160482 PUS7 -0.48 -5.66 -0.33 3.95e-8 Bipolar disorder (body mass index interaction); CESC cis rs3857067 1.000 rs1509943 chr4:95013366 A/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg20891558 chr2:74357851 NA 0.78 11.16 0.57 5.72e-24 Gestational age at birth (maternal effect); CESC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg07677032 chr17:61819896 STRADA 0.45 5.95 0.34 8.68e-9 Prudent dietary pattern; CESC cis rs6762 0.719 rs7936806 chr11:839186 G/C cg23754390 chr11:835074 CD151 0.32 5.56 0.32 6.52e-8 Mean platelet volume; CESC cis rs2074585 0.708 rs2589939 chr15:90930875 C/T cg22089800 chr15:90895588 ZNF774 0.69 9.63 0.51 5.17e-19 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs3008870 0.755 rs4655662 chr1:67416432 T/C cg02640540 chr1:67518911 SLC35D1 0.46 5.56 0.32 6.52e-8 Lymphocyte percentage of white cells; CESC cis rs13256369 0.802 rs11781257 chr8:8559663 A/T cg17143192 chr8:8559678 CLDN23 0.78 8.72 0.47 3.13e-16 Obesity-related traits; CESC cis rs4803468 0.967 rs4802116 chr19:41905540 C/T cg09537434 chr19:41945824 ATP5SL -1.02 -18.28 -0.75 7.49e-49 Height; CESC cis rs7264396 0.537 rs6119628 chr20:34170174 C/A cg04508476 chr20:34239394 CPNE1;RBM12 0.47 6.22 0.36 1.98e-9 Total cholesterol levels; CESC cis rs9457247 0.740 rs10946204 chr6:167451129 T/C cg07741184 chr6:167504864 NA 0.36 6.48 0.37 4.57e-10 Crohn's disease; CESC cis rs1953600 0.870 rs2573356 chr10:81949363 C/T cg00277334 chr10:82204260 NA 0.45 6.28 0.36 1.4e-9 Sarcoidosis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19763735 chr2:170550826 C2orf77;PHOSPHO2;KLHL23 -0.5 -7.09 -0.4 1.25e-11 Gambling; CESC cis rs16854884 0.683 rs10935505 chr3:143777966 T/C cg06585982 chr3:143692056 C3orf58 0.49 6.36 0.36 8.82e-10 Economic and political preferences (feminism/equality); CESC cis rs9660992 0.710 rs1768587 chr1:205236432 C/T cg21643547 chr1:205240462 TMCC2 -0.47 -6.34 -0.36 1.01e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs7208859 0.673 rs9894876 chr17:29182020 G/A cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs201673768 1 rs201673768 chr12:48699606 TGTTTTGTTTTG/T cg04545296 chr12:48745243 ZNF641 0.28 5.12 0.3 5.92e-7 Platelet count; CESC cis rs12369635 1.000 rs9645723 chr12:129554501 C/T cg01909103 chr12:129572610 TMEM132D -0.7 -6.01 -0.35 6.1e-9 Schizophrenia (inflammation and infection response interaction); CESC trans rs7839040 0.698 rs7836583 chr8:82928643 G/T cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs4253772 0.678 rs1055659 chr22:46638298 C/T cg24881330 chr22:46731750 TRMU 0.66 6.45 0.37 5.22e-10 LDL cholesterol;Cholesterol, total; CESC cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg03676636 chr4:99064102 C4orf37 0.35 5.37 0.31 1.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs831571 0.519 rs13059603 chr3:63827381 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.65 7.71 0.43 2.5e-13 Type 2 diabetes; CESC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg17372223 chr3:52568218 NT5DC2 -0.4 -5.97 -0.34 7.57e-9 Electroencephalogram traits; CESC cis rs1506636 0.886 rs6466878 chr7:123272278 T/C cg03229431 chr7:123269106 ASB15 -0.52 -6.88 -0.39 4.35e-11 Plateletcrit;Platelet count; CESC trans rs7618501 1.000 rs3811696 chr3:49761605 C/T cg21659725 chr3:3221576 CRBN -0.83 -13.7 -0.64 1.17e-32 Intelligence (multi-trait analysis); CESC cis rs1538970 1.000 rs4660853 chr1:45849090 C/T cg06784218 chr1:46089804 CCDC17 0.34 5.76 0.33 2.36e-8 Platelet count; CESC cis rs832540 0.931 rs832536 chr5:56212595 C/T cg24531977 chr5:56204891 C5orf35 -0.44 -5.49 -0.32 9.32e-8 Coronary artery disease; CESC cis rs722599 0.748 rs741096 chr14:75351487 A/G cg08847533 chr14:75593920 NEK9 -0.45 -5.51 -0.32 8.52e-8 IgG glycosylation; CESC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg07701084 chr6:150067640 NUP43 0.44 6.0 0.35 6.45e-9 Lung cancer; CESC cis rs4975616 0.773 rs414965 chr5:1324121 G/A cg06550200 chr5:1325588 CLPTM1L -0.68 -10.36 -0.54 2.42e-21 Lung cancer; CESC cis rs7843479 1.000 rs66824050 chr8:21815425 T/G cg17168535 chr8:21777572 XPO7 0.46 6.27 0.36 1.47e-9 Mean corpuscular volume; CESC cis rs6893300 0.542 rs3797774 chr5:179193970 C/T cg14593053 chr5:179126677 CANX 0.55 8.17 0.45 1.24e-14 Resting heart rate; CESC cis rs7264396 0.570 rs6060717 chr20:34544647 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -11.49 -0.58 4.75e-25 Total cholesterol levels; CESC cis rs56235845 0.796 rs13153019 chr5:176782218 T/C cg06060754 chr5:176797920 RGS14 0.51 5.14 0.3 5.42e-7 Hemoglobin concentration;Hematocrit; CESC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg08822215 chr16:89438651 ANKRD11 0.38 5.73 0.33 2.73e-8 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11949866 chr1:10754891 CASZ1 0.51 6.33 0.36 1.02e-9 Gut microbiome composition (summer); CESC cis rs959260 1.000 rs2117563 chr17:73368985 A/G cg12999837 chr17:73267436 MIF4GD -0.47 -5.5 -0.32 8.8e-8 Systemic lupus erythematosus; CESC cis rs826838 0.967 rs1719854 chr12:39127707 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16249798 chr1:38325439 MTF1 0.53 6.09 0.35 3.96e-9 Gut microbiome composition (summer); CESC cis rs6762 0.550 rs8672 chr11:838634 C/G cg23754390 chr11:835074 CD151 0.31 5.59 0.32 5.74e-8 Mean platelet volume; CESC trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg03929089 chr4:120376271 NA 0.76 9.94 0.52 5.31e-20 Height; CESC cis rs7726839 0.561 rs72703046 chr5:580129 T/C cg16447950 chr5:562315 NA -0.55 -6.2 -0.36 2.1e-9 Obesity-related traits; CESC cis rs7044106 0.615 rs10818470 chr9:123359204 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.67 9.49 0.5 1.42e-18 Hip circumference adjusted for BMI; CESC cis rs2439831 1.000 rs2584725 chr15:43793135 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.58 0.54 4.72e-22 Lung cancer in ever smokers; CESC cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg03060546 chr3:49711283 APEH 0.55 6.66 0.38 1.6e-10 Parkinson's disease; CESC cis rs2635047 0.783 rs9948677 chr18:44790343 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.46 0.32 1.1e-7 Educational attainment; CESC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg18446336 chr7:2847575 GNA12 -0.36 -5.59 -0.32 5.53e-8 Height; CESC cis rs62064224 0.614 rs2286645 chr17:30696292 C/T cg18200150 chr17:30822561 MYO1D 0.39 5.11 0.3 6.17e-7 Schizophrenia; CESC cis rs748404 0.650 rs518261 chr15:43573429 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.3 0.45 5.45e-15 Lung cancer; CESC cis rs17253792 0.822 rs75663029 chr14:56092385 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg25019033 chr10:957182 NA -0.58 -6.32 -0.36 1.1e-9 Eosinophil percentage of granulocytes; CESC cis rs4780401 0.933 rs4584833 chr16:11798758 C/T cg01061890 chr16:11836724 TXNDC11 -0.38 -5.07 -0.3 7.33e-7 Rheumatoid arthritis; CESC trans rs11098499 0.605 rs6833140 chr4:120266822 G/A cg25214090 chr10:38739885 LOC399744 0.59 7.99 0.44 4.13e-14 Corneal astigmatism; CESC cis rs10865397 0.506 rs6546810 chr2:73389716 A/G cg01422370 chr2:73384389 NA 0.46 7.31 0.41 3.08e-12 Intelligence (multi-trait analysis); CESC cis rs7078219 1.000 rs7081330 chr10:101274465 A/G cg09788492 chr10:101292477 NKX2-3 0.29 5.29 0.31 2.62e-7 Dental caries; CESC cis rs3747547 1.000 rs11788065 chr9:37925826 G/C cg13774184 chr9:37916125 SHB -0.71 -5.94 -0.34 9.05e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20930618 chr1:151162157 VPS72 0.45 6.07 0.35 4.47e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg13353311 chr5:59996240 DEPDC1B -0.49 -6.99 -0.39 2.28e-11 Asthma; CESC cis rs2425143 1.000 rs11167275 chr20:34340275 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.11 0.3 6.22e-7 Blood protein levels; CESC cis rs12200560 0.505 rs1334321 chr6:97079571 C/T cg06623918 chr6:96969491 KIAA0776 -0.45 -5.83 -0.34 1.57e-8 Coronary heart disease; CESC trans rs748404 0.578 rs552701 chr15:43613810 T/C cg24053811 chr14:70265306 SLC10A1 0.41 6.0 0.35 6.61e-9 Lung cancer; CESC cis rs4969178 0.931 rs6501208 chr17:76395038 A/T cg05887092 chr17:76393375 PGS1 0.57 9.02 0.48 4.04e-17 HDL cholesterol levels; CESC cis rs1707322 0.721 rs6665808 chr1:46162283 C/T cg03146154 chr1:46216737 IPP 0.76 10.9 0.56 4.26e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs916888 0.821 rs199513 chr17:44856932 A/G cg17911788 chr17:44343683 NA 0.48 6.4 0.37 7.19e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg19418458 chr7:158789849 NA -0.5 -8.11 -0.45 1.83e-14 Facial morphology (factor 20); CESC cis rs7312933 0.526 rs1669892 chr12:42811305 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.51 -6.75 -0.38 9.47e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg12463550 chr7:65579703 CRCP -0.52 -6.49 -0.37 4.08e-10 Aortic root size; CESC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg18099408 chr3:52552593 STAB1 -0.38 -6.53 -0.37 3.4e-10 Electroencephalogram traits; CESC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg16606324 chr3:10149918 C3orf24 0.42 5.09 0.3 6.72e-7 Alzheimer's disease; CESC cis rs7674212 0.570 rs1031804 chr4:104066049 C/T cg16532752 chr4:104119610 CENPE -0.45 -6.18 -0.35 2.43e-9 Type 2 diabetes; CESC cis rs3741151 0.773 rs58334887 chr11:73171510 A/C cg17517138 chr11:73019481 ARHGEF17 0.97 7.21 0.4 5.99e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs425277 1.000 rs809912 chr1:2078385 C/T cg04315214 chr1:2043799 PRKCZ -0.38 -5.3 -0.31 2.42e-7 Height; CESC cis rs8070740 0.838 rs8072363 chr17:5335752 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.57 6.75 0.38 9.56e-11 Menopause (age at onset); CESC cis rs34891900 0.507 rs12167823 chr22:18124362 G/A cg19898043 chr22:18121309 BCL2L13 0.62 7.38 0.41 2.02e-12 Sum neutrophil eosinophil counts; CESC trans rs7615952 0.599 rs6438955 chr3:125730333 C/A cg07211511 chr3:129823064 LOC729375 -0.59 -7.14 -0.4 9.16e-12 Blood pressure (smoking interaction); CESC cis rs4664293 0.764 rs1425044 chr2:160474937 C/T cg08347373 chr2:160653686 CD302 -0.3 -5.19 -0.3 4.13e-7 Monocyte percentage of white cells; CESC cis rs6502050 0.835 rs34620191 chr17:80149532 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.56e-7 Life satisfaction; CESC cis rs8067354 0.789 rs1292068 chr17:57929319 T/C cg13753209 chr17:57696993 CLTC 0.51 7.06 0.4 1.44e-11 Hemoglobin concentration; CESC cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg05347473 chr6:146136440 FBXO30 0.71 8.98 0.48 5.2e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs460214 0.576 rs2836604 chr21:40041295 A/C cg05519781 chr21:40033154 ERG -0.49 -6.22 -0.36 1.96e-9 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs8077889 0.917 rs72836556 chr17:41911824 G/T cg26893861 chr17:41843967 DUSP3 0.84 10.49 0.54 9.31e-22 Triglycerides; CESC cis rs17376456 0.825 rs13182631 chr5:93115701 A/G cg25358565 chr5:93447407 FAM172A 1.1 10.84 0.55 6.88e-23 Diabetic retinopathy; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg09315918 chr1:206137767 FAM72A 0.5 6.45 0.37 5.2e-10 Bronchopulmonary dysplasia; CESC cis rs72634258 0.503 rs2794666 chr1:7822009 A/G cg26816564 chr1:7831052 VAMP3 0.66 6.28 0.36 1.36e-9 Inflammatory bowel disease; CESC cis rs933688 1.000 rs7720132 chr5:90745105 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 12.13 0.6 3.17e-27 Smoking behavior; CESC cis rs7210086 0.808 rs72849443 chr17:70637437 G/A cg04206342 chr17:70636940 NA -0.35 -6.5 -0.37 3.91e-10 Ulcerative colitis; CESC cis rs2072438 0.503 rs1323474 chr9:123852859 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.37 5.26 0.31 2.93e-7 Rheumatoid arthritis; CESC cis rs1348850 0.914 rs12104588 chr2:178253675 G/A cg22681709 chr2:178499509 PDE11A -0.43 -6.29 -0.36 1.33e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg05283184 chr6:79620031 NA -0.42 -6.62 -0.38 1.93e-10 Intelligence (multi-trait analysis); CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg03395511 chr6:291903 DUSP22 -0.7 -8.8 -0.48 1.81e-16 Menopause (age at onset); CESC cis rs62064224 0.675 rs4795693 chr17:30636727 A/G cg18200150 chr17:30822561 MYO1D 0.39 5.21 0.3 3.89e-7 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13599271 chr3:58291905 RPP14 -0.46 -6.04 -0.35 5.25e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.59 0.38 2.33e-10 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09123307 chr7:6746650 ZNF12 -0.44 -6.05 -0.35 4.85e-9 Fibrinogen levels; CESC cis rs709400 1.000 rs2403205 chr14:104143385 C/T cg12935359 chr14:103987150 CKB -0.45 -6.04 -0.35 5.3e-9 Body mass index; CESC cis rs72781680 0.898 rs112985192 chr2:24102797 G/A cg08917208 chr2:24149416 ATAD2B 0.94 8.68 0.47 4.03e-16 Lymphocyte counts; CESC cis rs7617480 0.616 rs7429596 chr3:48808531 T/C cg07636037 chr3:49044803 WDR6 0.8 10.82 0.55 7.48e-23 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs7605827 0.930 rs1035246 chr2:15512891 G/A cg19274914 chr2:15703543 NA 0.31 5.51 0.32 8.7e-8 Educational attainment (years of education); CESC cis rs34779708 0.966 rs10827491 chr10:35427395 G/A cg04310649 chr10:35416472 CREM -0.52 -6.45 -0.37 5.15e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19538699 chr3:112281021 SLC35A5;ATG3 0.52 6.81 0.39 6.71e-11 Gut microbiota (bacterial taxa); CESC cis rs4423214 0.798 rs1894100 chr11:71130343 G/T cg05163923 chr11:71159392 DHCR7 -0.63 -7.19 -0.4 6.76e-12 Vitamin D levels; CESC cis rs10089 1.000 rs17164310 chr5:127493679 A/G cg19767477 chr5:127420684 SLC12A2 -0.38 -5.05 -0.3 8.14e-7 Ileal carcinoids; CESC cis rs7582720 1.000 rs4510208 chr2:203734866 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19230575 chr3:179041494 ZNF639 -0.39 -6.05 -0.35 4.79e-9 Gambling; CESC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg05564831 chr3:52568323 NT5DC2 0.47 7.51 0.42 9.1e-13 Bipolar disorder; CESC cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg26769984 chr7:1090371 C7orf50 0.67 7.6 0.42 5.05e-13 Bronchopulmonary dysplasia; CESC cis rs10206020 0.885 rs6746052 chr2:1576811 T/C cg12573674 chr2:1569213 NA -0.46 -5.2 -0.3 3.96e-7 IgG glycosylation; CESC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg07507251 chr3:52567010 NT5DC2 0.37 6.72 0.38 1.09e-10 Electroencephalogram traits; CESC cis rs727505 1.000 rs10464529 chr7:124520308 G/A cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs3008870 0.959 rs2985808 chr1:67367741 T/C cg02640540 chr1:67518911 SLC35D1 0.5 5.33 0.31 2.11e-7 Lymphocyte percentage of white cells; CESC cis rs763121 0.853 rs2072798 chr22:39148483 G/A cg14440974 chr22:39074834 NA -0.38 -5.25 -0.31 3.06e-7 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11913790 chr5:154136136 LARP1 -0.72 -7.72 -0.43 2.33e-13 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs10462754 chr5:246669 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.37 0.31 1.73e-7 Breast cancer; CESC cis rs2625529 0.652 rs3759820 chr15:72300031 A/C cg16672083 chr15:72433130 SENP8 0.44 6.72 0.38 1.09e-10 Red blood cell count; CESC cis rs667920 0.512 rs13065626 chr3:136294757 C/G cg15507776 chr3:136538369 TMEM22 -0.77 -6.78 -0.38 7.78e-11 Coronary artery disease; CESC cis rs12500824 0.564 rs62300854 chr4:77280999 T/C cg20311846 chr4:77356250 SHROOM3 0.37 6.88 0.39 4.32e-11 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21417675 chr7:128695180 LOC286016;TNPO3 -0.55 -6.25 -0.36 1.6e-9 Gut microbiome composition (summer); CESC cis rs9911578 0.835 rs9904993 chr17:56468569 G/T cg25039879 chr17:56429692 SUPT4H1 -0.39 -5.16 -0.3 4.81e-7 Intelligence (multi-trait analysis); CESC cis rs870825 0.616 rs7680639 chr4:185652915 C/T cg04058563 chr4:185651563 MLF1IP -0.6 -6.93 -0.39 3.28e-11 Blood protein levels; CESC cis rs2439831 1.000 rs2245908 chr15:43731454 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.28 0.53 4.37e-21 Lung cancer in ever smokers; CESC cis rs2370759 1.000 rs11594963 chr10:32625736 G/A cg01819863 chr10:32635814 EPC1 1.14 12.25 0.6 1.2100000000000001e-27 Sexual dysfunction (female); CESC cis rs6088580 0.634 rs2184836 chr20:32963369 A/G cg24642439 chr20:33292090 TP53INP2 -0.52 -6.9 -0.39 3.82e-11 Glomerular filtration rate (creatinine); CESC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.64 0.42 3.91e-13 Prudent dietary pattern; CESC cis rs1215050 0.791 rs783969 chr4:98906504 C/T cg05340658 chr4:99064831 C4orf37 0.46 5.93 0.34 9.58e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.07 -0.3 7.35e-7 Total body bone mineral density; CESC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg26119090 chr2:26468346 HADHA;HADHB 1.11 12.84 0.62 1.1e-29 Gut microbiome composition (summer); CESC cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg17211192 chr8:82754475 SNX16 0.49 6.32 0.36 1.09e-9 Diastolic blood pressure; CESC cis rs7659604 0.521 rs10001697 chr4:122677737 G/T cg19671926 chr4:122722719 EXOSC9 0.53 6.7 0.38 1.21e-10 Type 2 diabetes; CESC cis rs804292 1.000 rs804292 chr8:11643915 C/T cg26752888 chr8:11627280 NEIL2 -0.95 -10.95 -0.56 2.91e-23 Alcohol dependence;Nicotine use; CESC cis rs7084402 0.902 rs10763557 chr10:60341515 C/T cg07615347 chr10:60278583 BICC1 0.57 8.79 0.47 1.98e-16 Refractive error; CESC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg11644478 chr21:40555479 PSMG1 -0.79 -11.77 -0.59 5.07e-26 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06481699 chr7:101458740 CUX1 0.57 6.71 0.38 1.16e-10 Gut microbiome composition (summer); CESC cis rs11792861 0.781 rs874864 chr9:111728718 C/T cg13535736 chr9:111863775 C9orf5 -0.42 -5.74 -0.33 2.62e-8 Menarche (age at onset); CESC cis rs2635047 0.837 rs2571009 chr18:44650279 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.49 6.86 0.39 4.72e-11 Educational attainment; CESC cis rs3747547 0.539 rs11791344 chr9:38125272 C/T cg13774184 chr9:37916125 SHB -0.67 -5.99 -0.35 6.95e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.57e-7 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08655701 chr19:10363255 MRPL4 0.59 6.45 0.37 5.22e-10 Gut microbiome composition (summer); CESC cis rs854765 0.964 rs2230316 chr17:17997209 C/T cg16928487 chr17:17741425 SREBF1 0.55 8.72 0.47 3.08e-16 Total body bone mineral density; CESC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg09323728 chr8:95962352 TP53INP1 -0.4 -8.68 -0.47 4.05e-16 Type 2 diabetes; CESC cis rs9457247 0.663 rs7749278 chr6:167435325 C/T cg23791538 chr6:167370224 RNASET2 0.55 7.43 0.42 1.46e-12 Crohn's disease; CESC cis rs7568458 0.709 rs56819945 chr2:85755139 C/T cg02493740 chr2:85810744 VAMP5 -0.56 -8.34 -0.46 4.12e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs2288073 0.965 rs6545335 chr2:24422011 G/A cg06627628 chr2:24431161 ITSN2 -0.78 -9.39 -0.5 2.93e-18 Venous thromboembolism (SNP x SNP interaction); CESC cis rs6484504 0.576 rs2150213 chr11:31244634 A/G cg14844989 chr11:31128820 NA -0.43 -6.01 -0.35 6.1e-9 Red blood cell count; CESC cis rs2204008 0.619 rs8189576 chr12:38307275 G/A cg26384229 chr12:38710491 ALG10B -0.44 -5.78 -0.33 2.1e-8 Bladder cancer; CESC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.07 -0.4 1.39e-11 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18483322 chr2:97523826 ANKRD39 0.54 6.52 0.37 3.63e-10 Gut microbiome composition (summer); CESC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg24675658 chr1:53192096 ZYG11B -0.68 -9.7 -0.51 3.13e-19 Monocyte count; CESC trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg15556689 chr8:8085844 FLJ10661 -0.66 -7.92 -0.44 6.62e-14 Systolic blood pressure; CESC cis rs3820068 0.581 rs12385690 chr1:15932932 A/T cg13390004 chr1:15929781 NA 0.34 5.45 0.32 1.14e-7 Systolic blood pressure; CESC cis rs897984 0.683 rs12926237 chr16:30837596 C/T cg00531865 chr16:30841666 NA 0.56 8.06 0.44 2.55e-14 Dementia with Lewy bodies; CESC cis rs7923452 0.938 rs34560372 chr10:30773831 G/A cg25182066 chr10:30743637 MAP3K8 0.47 5.21 0.31 3.73e-7 Itch intensity from mosquito bite; CESC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg24675658 chr1:53192096 ZYG11B -0.6 -7.74 -0.43 2.06e-13 Monocyte count; CESC cis rs734999 0.588 rs78506337 chr1:2537095 G/A cg18854424 chr1:2615690 NA 0.28 5.51 0.32 8.66e-8 Ulcerative colitis; CESC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.14 0.3 5.43e-7 Bipolar disorder; CESC cis rs703842 1.000 rs10783847 chr12:58196447 G/A cg00677455 chr12:58241039 CTDSP2 0.53 6.96 0.39 2.71e-11 Multiple sclerosis; CESC cis rs4604732 0.536 rs76191272 chr1:247628055 A/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.53 6.57 0.37 2.7e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7656342 0.636 rs4697902 chr4:9863936 T/C cg11266682 chr4:10021025 SLC2A9 -0.35 -5.46 -0.32 1.08e-7 Gut microbiota (bacterial taxa); CESC cis rs8002861 0.905 rs6561150 chr13:44460470 C/T cg14210620 chr13:44453864 C13orf31;CCDC122 0.48 6.01 0.35 6.16e-9 Leprosy; CESC cis rs2880765 0.566 rs55899824 chr15:86004091 C/T cg19183879 chr15:85880815 NA -0.31 -5.88 -0.34 1.2e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12267883 chr13:30424914 UBL3 -0.62 -7.16 -0.4 7.86e-12 Gut microbiome composition (summer); CESC trans rs1814175 0.791 rs9787917 chr11:49937281 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -21.21 -0.79 4.77e-59 Height; CESC trans rs1728785 1.000 rs1728792 chr16:68596534 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 7.95 0.44 5.4e-14 Ulcerative colitis; CESC trans rs4942242 0.663 rs9525812 chr13:44200099 T/C cg19169023 chr15:41853346 TYRO3 -0.59 -7.66 -0.43 3.51e-13 Response to tocilizumab in rheumatoid arthritis; CESC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg02592271 chr2:27665507 KRTCAP3 -0.29 -6.02 -0.35 5.85e-9 Total body bone mineral density; CESC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg04166393 chr7:2884313 GNA12 0.58 7.51 0.42 8.92e-13 Height; CESC cis rs9837602 0.507 rs793448 chr3:99532949 G/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.53 -6.26 -0.36 1.52e-9 Breast cancer; CESC cis rs10876993 0.855 rs1678520 chr12:58049319 C/G cg18357645 chr12:58087776 OS9 0.6 9.04 0.49 3.45e-17 Celiac disease or Rheumatoid arthritis; CESC cis rs711830 0.931 rs717852 chr2:177031623 C/T cg13092806 chr2:177043255 NA 0.87 11.79 0.59 4.66e-26 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CESC cis rs4073582 0.516 rs1151539 chr11:66031660 C/T cg14036092 chr11:66035641 RAB1B 0.56 7.87 0.44 9.14e-14 Gout; CESC cis rs6460942 0.597 rs62449509 chr7:12515013 C/T cg10578991 chr7:12443926 VWDE -0.49 -5.07 -0.3 7.32e-7 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04626574 chr22:26879726 HPS4;SRRD -0.44 -6.11 -0.35 3.47e-9 Gambling; CESC cis rs6500395 0.651 rs28432694 chr16:48666310 A/T cg04672837 chr16:48644449 N4BP1 0.43 5.19 0.3 4.09e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs28489187 0.683 rs6704103 chr1:85868657 C/A cg16011679 chr1:85725395 C1orf52 -0.48 -5.7 -0.33 3.19e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg24531977 chr5:56204891 C5orf35 1.0 12.95 0.62 4.71e-30 Initial pursuit acceleration; CESC trans rs1545843 0.593 rs4761085 chr12:84794017 A/T cg03015433 chr16:56623111 MT3 -0.34 -6.12 -0.35 3.37e-9 Major depressive disorder; CESC trans rs3925158 0.510 rs12054266 chr3:38302912 A/G cg23247845 chr10:3679085 NA 0.67 6.1 0.35 3.77e-9 Gut microbiota (bacterial taxa); CESC cis rs2439831 0.702 rs2467402 chr15:44024490 A/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.59 -7.56 -0.42 6.67e-13 Lung cancer in ever smokers; CESC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg17372223 chr3:52568218 NT5DC2 0.51 7.94 0.44 5.81e-14 Electroencephalogram traits; CESC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.35e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg14159672 chr1:205819179 PM20D1 0.76 11.29 0.57 2.11e-24 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09475402 chr22:47158619 TBC1D22A 0.55 6.01 0.35 6.04e-9 Gut microbiome composition (summer); CESC cis rs2635047 0.811 rs17785603 chr18:44769534 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 5.95 0.34 8.42e-9 Educational attainment; CESC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg12463550 chr7:65579703 CRCP -0.52 -6.41 -0.37 6.69e-10 Aortic root size; CESC cis rs2074585 0.583 rs28406958 chr15:91069364 C/A cg10434728 chr15:90938212 IQGAP1 -0.32 -5.11 -0.3 6.21e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs2952156 0.920 rs2517953 chr17:37841211 G/C cg07936489 chr17:37558343 FBXL20 -0.6 -7.71 -0.43 2.57e-13 Asthma; CESC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs896854 0.902 rs726816 chr8:95968413 T/G cg13393036 chr8:95962371 TP53INP1 -0.51 -10.77 -0.55 1.15e-22 Type 2 diabetes; CESC trans rs3741578 0.702 rs725956 chr12:57331936 A/G cg27208169 chr17:17603584 RAI1 0.44 6.07 0.35 4.31e-9 Asthma; CESC cis rs67311347 1.000 rs73078158 chr3:40472567 G/C cg24209194 chr3:40518798 ZNF619 0.51 6.3 0.36 1.22e-9 Renal cell carcinoma; CESC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs35110281 0.837 rs2838343 chr21:45078035 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 6.63 0.38 1.91e-10 Mean corpuscular volume; CESC cis rs12541635 0.639 rs10095827 chr8:106984403 A/G cg10147462 chr8:107024639 NA 0.46 6.71 0.38 1.19e-10 Age of smoking initiation; CESC cis rs12477438 0.520 rs6743355 chr2:99732360 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.61 0.69 2.15e-39 Chronic sinus infection; CESC trans rs11039798 0.588 rs10838923 chr11:48534864 C/G cg03929089 chr4:120376271 NA 0.6 6.21 0.36 2.06e-9 Axial length; CESC cis rs3091242 0.866 rs11249249 chr1:25758134 A/G cg02931644 chr1:25747376 RHCE 0.46 7.92 0.44 6.55e-14 Erythrocyte sedimentation rate; CESC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.07 -0.44 2.4e-14 Personality dimensions; CESC cis rs12136530 0.727 rs4911998 chr1:19765834 C/T cg01832549 chr1:19774989 CAPZB -0.47 -6.76 -0.38 8.85e-11 Lead levels in blood; CESC trans rs60843830 1.000 rs56321614 chr2:268191 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 8.16 0.45 1.35e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7301826 0.651 rs10848206 chr12:131281471 G/C cg11011512 chr12:131303247 STX2 0.47 5.71 0.33 3.07e-8 Plasma plasminogen activator levels; CESC cis rs7149337 1.000 rs4901103 chr14:51746873 C/T cg23942311 chr14:51606299 NA 0.41 6.78 0.38 7.87e-11 Cancer; CESC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.33 -5.74 -0.33 2.58e-8 Electroencephalogram traits; CESC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg04287289 chr16:89883240 FANCA 0.87 14.99 0.68 3.22e-37 Vitiligo; CESC cis rs8114671 0.562 rs2223881 chr20:33506463 A/C cg07148914 chr20:33460835 GGT7 0.52 6.8 0.39 6.88e-11 Height; CESC trans rs1422110 0.681 rs35625401 chr5:85465408 G/A cg01787110 chr1:109008453 NBPF6 0.42 6.23 0.36 1.81e-9 Attention function in attention deficit hyperactive disorder; CESC cis rs5758511 0.689 rs55906806 chr22:42644471 C/T cg00645731 chr22:42541494 CYP2D7P1 0.55 6.96 0.39 2.68e-11 Birth weight; CESC cis rs6426558 0.502 rs2813965 chr1:227445733 A/G cg10327440 chr1:227177885 CDC42BPA 0.52 6.4 0.37 7.17e-10 Neutrophil percentage of white cells; CESC cis rs1707322 1.000 rs9803784 chr1:46401907 T/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg04267008 chr7:1944627 MAD1L1 -0.74 -9.88 -0.52 8.45e-20 Bipolar disorder and schizophrenia; CESC cis rs7772486 0.790 rs6926076 chr6:146232804 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -13.36 -0.63 1.78e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg23711669 chr6:146136114 FBXO30 1.0 15.28 0.68 3.05e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.95 0.34 8.45e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg06481639 chr22:41940642 POLR3H 0.6 5.92 0.34 9.88e-9 Vitiligo; CESC cis rs7927592 0.763 rs1193699 chr11:68249480 C/G cg20283391 chr11:68216788 NA -0.47 -5.94 -0.34 8.94e-9 Total body bone mineral density; CESC cis rs875971 0.658 rs432667 chr7:65514633 A/G cg11764359 chr7:65958608 NA 0.88 13.01 0.62 3.05e-30 Aortic root size; CESC trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg15704280 chr7:45808275 SEPT13 0.82 12.84 0.62 1.17e-29 Coronary artery disease; CESC cis rs4595586 0.525 rs7968566 chr12:39377200 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs10771431 0.810 rs10771418 chr12:9358995 A/G cg08997352 chr12:9597637 DDX12 -0.77 -10.44 -0.54 1.34e-21 Breast size; CESC cis rs1801251 1.000 rs1446308 chr2:233639309 T/C cg25237894 chr2:233734115 C2orf82 0.46 8.06 0.44 2.6e-14 Coronary artery disease; CESC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg25272121 chr1:152190972 HRNR -0.39 -5.85 -0.34 1.48e-8 Inflammatory skin disease; CESC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg06494592 chr3:125709126 NA -0.44 -5.05 -0.3 8.41e-7 Blood pressure (smoking interaction); CESC cis rs1008375 0.898 rs4698623 chr4:17594702 T/C cg16339924 chr4:17578868 LAP3 0.69 8.85 0.48 1.24e-16 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6964587 0.620 rs6967588 chr7:91643402 G/T cg17063962 chr7:91808500 NA 0.46 6.55 0.37 2.91e-10 Breast cancer; CESC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg00310523 chr12:86230176 RASSF9 -0.31 -5.04 -0.3 8.55e-7 Major depressive disorder; CESC cis rs4835473 0.932 rs7668698 chr4:144907486 C/G cg25736465 chr4:144833511 NA 0.41 6.29 0.36 1.28e-9 Immature fraction of reticulocytes; CESC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg00129232 chr17:37814104 STARD3 0.51 6.38 0.37 7.72e-10 Glomerular filtration rate (creatinine); CESC trans rs526821 0.553 rs510095 chr11:55289154 T/C cg15704280 chr7:45808275 SEPT13 -0.52 -6.42 -0.37 6.24e-10 Pediatric bone mineral density (spine); CESC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg04369109 chr6:150039330 LATS1 -0.42 -5.95 -0.34 8.52e-9 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13825663 chr2:96873994 STARD7 0.56 6.15 0.35 2.79e-9 Gut microbiome composition (summer); CESC cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg12365402 chr11:9010492 NRIP3 0.34 5.3 0.31 2.43e-7 Hemoglobin concentration; CESC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg17178900 chr1:205818956 PM20D1 -0.49 -6.9 -0.39 3.93e-11 Menarche (age at onset); CESC cis rs9303542 0.559 rs12938390 chr17:46614722 T/C cg04904318 chr17:46607828 HOXB1 -0.6 -5.73 -0.33 2.76e-8 Ovarian cancer;Epithelial ovarian cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20318713 chr1:45805724 MUTYH;TOE1 0.71 8.12 0.45 1.76e-14 Gut microbiome composition (summer); CESC cis rs7246657 0.943 rs6508733 chr19:38000548 A/T cg23950597 chr19:37808831 NA -0.49 -5.57 -0.32 6.39e-8 Coronary artery calcification; CESC cis rs7819412 0.715 rs2409727 chr8:11043236 C/T cg21775007 chr8:11205619 TDH -0.37 -5.14 -0.3 5.47e-7 Triglycerides; CESC cis rs7481584 0.624 rs451060 chr11:3056389 G/A cg25174290 chr11:3078921 CARS -0.48 -6.7 -0.38 1.24e-10 Calcium levels; CESC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg11663144 chr21:46675770 NA -0.63 -9.95 -0.52 5.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6938 0.534 rs59945415 chr15:75228427 C/A cg14664628 chr15:75095509 CSK -0.55 -7.15 -0.4 8.2e-12 Breast cancer; CESC cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg14440974 chr22:39074834 NA -0.42 -5.77 -0.33 2.19e-8 Menopause (age at onset); CESC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg04287289 chr16:89883240 FANCA 0.91 16.29 0.71 7.88e-42 Vitiligo; CESC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.92 -0.52 6.14e-20 Developmental language disorder (linguistic errors); CESC cis rs950169 0.922 rs67804993 chr15:85104030 T/G cg17507749 chr15:85114479 UBE2QP1 0.58 6.4 0.37 6.88e-10 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21640038 chr17:65362901 PSMD12 0.5 6.72 0.38 1.1e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7713065 1.000 rs7713065 chr5:131788334 A/C cg09877947 chr5:131593287 PDLIM4 0.49 5.77 0.33 2.22e-8 Lung function (FEV1/FVC); CESC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg16590910 chr6:42928470 GNMT 0.37 5.19 0.3 4.12e-7 Alzheimer's disease in APOE e4+ carriers; CESC trans rs11098499 0.863 rs11098531 chr4:120465001 G/A cg25214090 chr10:38739885 LOC399744 0.67 9.21 0.49 1.05e-17 Corneal astigmatism; CESC cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg07636037 chr3:49044803 WDR6 1.01 18.68 0.75 2.81e-50 Parkinson's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24507739 chr2:27546399 MPV17 -0.41 -6.19 -0.36 2.26e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2191566 0.691 rs56149185 chr19:44588067 A/T cg20607764 chr19:44506953 ZNF230 -0.4 -5.31 -0.31 2.28e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs6500602 0.702 rs3789038 chr16:4546586 C/G cg08645402 chr16:4508243 NA -0.51 -7.78 -0.43 1.6e-13 Schizophrenia; CESC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg18876405 chr7:65276391 NA -0.53 -7.2 -0.4 6.41e-12 Aortic root size; CESC cis rs67478160 0.654 rs11628240 chr14:104218135 A/G cg01849466 chr14:104193079 ZFYVE21 -0.5 -6.93 -0.39 3.17e-11 Schizophrenia; CESC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -7.76 -0.43 1.81e-13 Tonsillectomy; CESC cis rs4077515 0.901 rs11791262 chr9:139271919 C/T cg14169450 chr9:139327907 INPP5E 0.37 5.4 0.31 1.47e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg16339924 chr4:17578868 LAP3 0.71 8.94 0.48 6.8e-17 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2075371 0.835 rs1646724 chr7:134001875 T/G cg11752832 chr7:134001865 SLC35B4 0.56 7.31 0.41 3.19e-12 Mean platelet volume; CESC cis rs4803468 1.000 rs284650 chr19:41927129 A/G cg09537434 chr19:41945824 ATP5SL -1.1 -20.32 -0.78 5.54e-56 Height; CESC cis rs35110281 0.807 rs1598206 chr21:45058776 A/G cg01579765 chr21:45077557 HSF2BP -0.58 -10.03 -0.52 2.7e-20 Mean corpuscular volume; CESC cis rs939658 0.776 rs4778925 chr15:79443791 C/T cg17916960 chr15:79447300 NA -0.37 -6.13 -0.35 3.13e-9 Refractive error; CESC cis rs7107174 1.000 rs10899458 chr11:78007451 A/T cg02023728 chr11:77925099 USP35 0.5 6.69 0.38 1.33e-10 Testicular germ cell tumor; CESC cis rs73019876 0.869 rs2359812 chr19:22153495 A/T cg11619707 chr19:22235551 ZNF257 -0.28 -5.11 -0.3 6.09e-7 Testicular germ cell tumor; CESC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg15145296 chr3:125709740 NA -0.56 -5.97 -0.34 7.52e-9 Blood pressure (smoking interaction); CESC cis rs11098499 0.697 rs4560394 chr4:120313435 T/G cg24375607 chr4:120327624 NA 0.46 5.52 0.32 8.27e-8 Corneal astigmatism; CESC cis rs1927790 0.616 rs1925119 chr13:96939586 C/A cg02571835 chr13:96230311 CLDN10 -0.34 -5.23 -0.31 3.53e-7 Body mass index; CESC cis rs2070488 0.775 rs762318 chr3:38516369 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 13.27 0.63 3.79e-31 Electrocardiographic conduction measures; CESC cis rs3540 0.512 rs3930162 chr15:91075129 C/T cg22089800 chr15:90895588 ZNF774 -0.63 -8.44 -0.46 2.12e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs4808199 0.947 rs754255 chr19:19578890 T/C cg03709012 chr19:19516395 GATAD2A 1.14 13.23 0.63 4.9e-31 Nonalcoholic fatty liver disease; CESC cis rs9911578 0.757 rs8081906 chr17:56631907 A/T cg12560992 chr17:57184187 TRIM37 -0.86 -12.17 -0.6 2.26e-27 Intelligence (multi-trait analysis); CESC cis rs2228479 0.850 rs17226428 chr16:89842884 T/A cg19635926 chr16:89946313 TCF25 0.67 5.03 0.3 9.05e-7 Skin colour saturation; CESC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg12463550 chr7:65579703 CRCP 0.56 7.21 0.41 5.78e-12 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07928541 chr7:151038942 NUB1 -0.45 -6.03 -0.35 5.46e-9 Fibrinogen levels; CESC cis rs2733201 1.000 rs2042741 chr15:44390286 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.47 -0.32 1.06e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC trans rs35110281 0.811 rs4819264 chr21:45017349 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 7.28 0.41 3.8e-12 Mean corpuscular volume; CESC cis rs7091068 0.518 rs1543580 chr10:95446811 C/T cg20715218 chr10:95462985 C10orf4 0.53 6.47 0.37 4.62e-10 Urinary tract infection frequency; CESC cis rs4588572 0.601 rs10070202 chr5:77792462 A/C cg11547950 chr5:77652471 NA -0.43 -5.53 -0.32 7.68e-8 Triglycerides; CESC cis rs2732480 0.500 rs1387257 chr12:48636666 C/A cg24011408 chr12:48396354 COL2A1 0.42 5.83 0.34 1.59e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs12618769 0.597 rs4599165 chr2:99144483 G/A cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC trans rs55704346 0.507 rs1533133 chr4:25384305 T/C cg01822600 chr1:245751692 KIF26B 0.43 6.27 0.36 1.44e-9 Tonsillectomy; CESC trans rs11252926 0.589 rs12359901 chr10:475068 A/G cg00953403 chr17:74099816 EXOC7 -0.55 -7.01 -0.4 2.01e-11 Psychosis in Alzheimer's disease; CESC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg22968622 chr17:43663579 NA -1.19 -16.22 -0.71 1.43e-41 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg12564285 chr5:131593104 PDLIM4 0.38 5.78 0.33 2.08e-8 Acylcarnitine levels; CESC cis rs55871839 0.708 rs4738730 chr8:59808935 A/T cg07426533 chr8:59803705 TOX -0.44 -6.41 -0.37 6.5e-10 Pneumonia; CESC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg14664628 chr15:75095509 CSK -0.59 -8.01 -0.44 3.71e-14 Breast cancer; CESC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg07507251 chr3:52567010 NT5DC2 0.42 7.17 0.4 7.35e-12 Bipolar disorder; CESC cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg24308560 chr3:49941425 MST1R -0.63 -9.02 -0.48 3.81e-17 Intelligence (multi-trait analysis); CESC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs55882075 0.808 rs6867806 chr5:179179585 C/G cg14593053 chr5:179126677 CANX 0.42 5.48 0.32 1.01e-7 Monocyte percentage of white cells; CESC cis rs3733585 0.699 rs28613263 chr4:9964880 C/T cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs881375 0.678 rs1014530 chr9:123685092 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.54 0.32 7.25e-8 Rheumatoid arthritis; CESC cis rs7017914 0.967 rs13255735 chr8:71859739 C/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.43 -5.42 -0.32 1.33e-7 Bone mineral density; CESC cis rs1256061 0.603 rs1256037 chr14:64743301 G/A cg21174375 chr14:64681225 SYNE2 0.51 6.77 0.38 8.38e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg19077165 chr18:44547161 KATNAL2 0.49 6.6 0.38 2.19e-10 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05193570 chr5:893022 TRIP13;BRD9 0.59 6.76 0.38 8.51e-11 Gut microbiome composition (summer); CESC cis rs365132 1.000 rs7718874 chr5:176358065 A/G cg16309518 chr5:176445507 NA -0.39 -5.72 -0.33 2.93e-8 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs17253792 0.822 rs76164147 chr14:56140369 T/C cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs3015497 0.624 rs3015488 chr14:51135309 A/G cg26011998 chr14:51135199 SAV1 -0.62 -7.28 -0.41 3.87e-12 Mean platelet volume; CESC cis rs2243480 0.901 rs778730 chr7:65823325 T/A cg13147721 chr7:65941812 NA -0.95 -8.96 -0.48 6.14e-17 Diabetic kidney disease; CESC cis rs3767633 0.925 rs4656339 chr1:161915387 A/T cg09175582 chr1:161736000 ATF6 0.88 7.42 0.41 1.6e-12 IgG glycosylation; CESC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg04315214 chr1:2043799 PRKCZ -0.44 -7.05 -0.4 1.53e-11 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02070114 chr5:139555300 C5orf32 0.57 6.52 0.37 3.51e-10 Gut microbiome composition (summer); CESC cis rs11098499 0.954 rs28429722 chr4:120300093 G/A cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs11098499 0.604 rs34278750 chr4:120571136 G/A cg09307838 chr4:120376055 NA 0.76 9.58 0.51 7.28e-19 Corneal astigmatism; CESC cis rs12282928 0.788 rs753095 chr11:48328644 C/T cg26585981 chr11:48327164 OR4S1 0.38 5.32 0.31 2.25e-7 Migraine - clinic-based; CESC cis rs854765 0.562 rs2955381 chr17:17945500 G/C cg16928487 chr17:17741425 SREBF1 0.55 9.13 0.49 1.86e-17 Total body bone mineral density; CESC cis rs7084402 0.967 rs2393448 chr10:60333260 T/G cg07615347 chr10:60278583 BICC1 0.59 9.23 0.49 9.22e-18 Refractive error; CESC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Parkinson's disease; CESC cis rs9814567 1.000 rs6793487 chr3:134299426 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.41 5.52 0.32 8.13e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2243480 1.000 rs186378 chr7:65582058 A/C cg12463550 chr7:65579703 CRCP 0.74 5.77 0.33 2.23e-8 Diabetic kidney disease; CESC cis rs8099014 0.861 rs4940705 chr18:56120155 G/A cg19312305 chr18:56117016 MIR122 -0.27 -5.29 -0.31 2.61e-7 Platelet count; CESC cis rs6484504 0.600 rs2616815 chr11:31327316 C/T cg14844989 chr11:31128820 NA 0.39 5.51 0.32 8.53e-8 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16626480 chr22:25575426 KIAA1671 -0.56 -6.01 -0.35 6.25e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6060717 0.536 rs3829829 chr20:34537160 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.71 6.36 0.36 8.95e-10 Hip circumference adjusted for BMI; CESC cis rs7586879 0.575 rs6721750 chr2:25128719 A/G cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.02e-11 Body mass index; CESC cis rs7264396 0.790 rs6121018 chr20:34249060 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 3.14e-26 Total cholesterol levels; CESC cis rs4474465 1.000 rs7950813 chr11:78215082 A/T cg27205649 chr11:78285834 NARS2 0.44 5.36 0.31 1.8e-7 Alzheimer's disease (survival time); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04066316 chr4:189433040 NA 0.38 6.08 0.35 4.21e-9 Fibrinogen levels; CESC cis rs11997175 0.692 rs6995075 chr8:33673816 G/A ch.8.33884649F chr8:33765107 NA 0.49 6.15 0.35 2.83e-9 Body mass index; CESC cis rs910316 0.789 rs175444 chr14:75601782 G/C cg08847533 chr14:75593920 NEK9 -0.91 -15.66 -0.69 1.38e-39 Height; CESC cis rs4588572 0.644 rs891150 chr5:77761794 G/A cg11547950 chr5:77652471 NA -0.4 -5.37 -0.31 1.73e-7 Triglycerides; CESC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg04414720 chr1:150670196 GOLPH3L 0.55 7.33 0.41 2.84e-12 Melanoma; CESC cis rs2425143 1.000 rs6060642 chr20:34449840 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.69 0.33 3.4e-8 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08209163 chr13:28024472 MTIF3 -0.45 -6.43 -0.37 6.02e-10 Fibrinogen levels; CESC cis rs9926296 0.572 rs8047581 chr16:89884502 C/T cg07648498 chr16:89883185 FANCA 0.45 5.48 0.32 9.91e-8 Vitiligo; CESC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.45 -6.55 -0.37 2.94e-10 Total body bone mineral density; CESC cis rs4900538 0.750 rs12590618 chr14:102808330 C/T cg18135206 chr14:102964638 TECPR2 -0.59 -7.01 -0.4 1.95e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs116095464 0.558 rs7730700 chr5:264713 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.86e-15 Breast cancer; CESC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg19077165 chr18:44547161 KATNAL2 -0.62 -9.44 -0.5 2.05e-18 Personality dimensions; CESC cis rs2637266 0.703 rs846635 chr10:78535132 G/A cg18941641 chr10:78392320 NA 0.41 7.79 0.43 1.48e-13 Pulmonary function; CESC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg03188948 chr7:1209495 NA 0.59 6.05 0.35 4.95e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg10691866 chr7:65817282 TPST1 0.31 5.15 0.3 5.12e-7 Aortic root size; CESC cis rs2839186 0.900 rs56840278 chr21:47708933 T/G cg10351095 chr21:47802916 PCNT -0.5 -6.69 -0.38 1.35e-10 Testicular germ cell tumor; CESC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg10541313 chr22:46663664 TTC38 0.74 5.91 0.34 1.02e-8 LDL cholesterol;Cholesterol, total; CESC cis rs12822507 0.831 rs34975957 chr12:12786190 G/A cg04607235 chr12:12878440 APOLD1 -0.51 -6.48 -0.37 4.43e-10 Systemic lupus erythematosus; CESC cis rs6061231 0.631 rs2427317 chr20:60975725 C/T cg15674680 chr20:60982522 CABLES2 0.42 5.35 0.31 1.89e-7 Colorectal cancer; CESC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg19592336 chr6:28129416 ZNF389 0.47 6.7 0.38 1.21e-10 Cardiac Troponin-T levels; CESC cis rs96067 0.652 rs274137 chr1:36577945 A/G cg27506609 chr1:36549197 TEKT2 -0.4 -5.1 -0.3 6.45e-7 Corneal structure; CESC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg11941060 chr3:133502564 NA -0.5 -6.47 -0.37 4.79e-10 Iron status biomarkers; CESC cis rs17376456 0.877 rs28539612 chr5:93499099 C/T cg21475434 chr5:93447410 FAM172A 0.9 7.81 0.43 1.35e-13 Diabetic retinopathy; CESC cis rs473651 0.503 rs515342 chr2:239367296 A/G cg18131467 chr2:239335373 ASB1 -0.68 -8.07 -0.44 2.4e-14 Multiple system atrophy; CESC cis rs17253792 0.822 rs10083493 chr14:56045411 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.88 0.34 1.25e-8 Putamen volume; CESC cis rs2952156 0.883 rs8077172 chr17:37834977 G/T cg20243544 chr17:37824526 PNMT 0.63 8.38 0.46 3.08e-15 Asthma; CESC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg22800045 chr5:56110881 MAP3K1 0.84 10.23 0.53 6.2e-21 Initial pursuit acceleration; CESC trans rs17508449 0.865 rs80348557 chr1:114151116 C/T cg23028848 chr11:57092561 TNKS1BP1 -0.77 -6.14 -0.35 2.98e-9 Leprosy; CESC cis rs6980507 0.523 rs2974294 chr8:42369473 C/T cg09913449 chr8:42400586 C8orf40 -0.36 -5.66 -0.33 3.84e-8 Glycated hemoglobin levels; CESC cis rs9487051 0.735 rs351756 chr6:109538773 A/G cg01475377 chr6:109611718 NA 0.39 5.82 0.34 1.68e-8 Reticulocyte fraction of red cells; CESC cis rs8141529 0.748 rs5752826 chr22:29269808 A/G cg02153584 chr22:29168773 CCDC117 0.56 7.45 0.42 1.34e-12 Lymphocyte counts; CESC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg08704250 chr15:31115839 NA 0.64 8.93 0.48 7.57e-17 Huntington's disease progression; CESC cis rs853679 0.882 rs9380069 chr6:28203300 A/G cg19592336 chr6:28129416 ZNF389 0.54 5.5 0.32 8.89e-8 Depression; CESC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg18876405 chr7:65276391 NA -0.51 -7.01 -0.4 1.94e-11 Aortic root size; CESC cis rs4955124 0.558 rs12485651 chr3:32018536 C/T cg05935571 chr3:32023257 ZNF860;OSBPL10 0.98 8.8 0.48 1.77e-16 Schizophrenia; CESC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.5 -0.32 9.07e-8 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13682598 chr10:135195405 PAOX 0.48 6.53 0.37 3.33e-10 Fibrinogen levels; CESC cis rs12476592 0.602 rs9789351 chr2:63740614 A/G cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg07636037 chr3:49044803 WDR6 1.07 18.96 0.76 3.01e-51 Parkinson's disease; CESC cis rs7617480 0.648 rs4974083 chr3:49000626 A/G cg07636037 chr3:49044803 WDR6 0.87 11.16 0.57 5.93e-24 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs9611565 0.694 rs79008 chr22:41850500 C/T cg06481639 chr22:41940642 POLR3H -0.56 -5.78 -0.33 2.07e-8 Vitiligo; CESC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg05313129 chr8:58192883 C8orf71 -0.54 -6.23 -0.36 1.83e-9 Developmental language disorder (linguistic errors); CESC cis rs1707322 1.000 rs11211232 chr1:46411146 C/T cg03146154 chr1:46216737 IPP 0.78 10.82 0.55 7.98e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg19723775 chr5:179050963 HNRNPH1 0.51 6.8 0.39 6.92e-11 Lung cancer; CESC cis rs7100689 0.577 rs9421464 chr10:82043426 C/T cg00277334 chr10:82204260 NA -0.53 -7.04 -0.4 1.62e-11 Post bronchodilator FEV1; CESC cis rs9549260 0.727 rs4603422 chr13:41148353 T/C cg21288729 chr13:41239152 FOXO1 0.63 7.94 0.44 5.91e-14 Red blood cell count; CESC cis rs10771431 0.967 rs7137443 chr12:9372029 C/T cg08997352 chr12:9597637 DDX12 -0.67 -8.9 -0.48 9.24e-17 Breast size; CESC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg12648201 chr2:27665141 KRTCAP3 -0.31 -5.65 -0.33 4.22e-8 Total body bone mineral density; CESC cis rs55728055 0.661 rs55931230 chr22:32028028 T/A cg01338084 chr22:32026380 PISD 1.26 8.23 0.45 8.62e-15 Age-related hearing impairment; CESC trans rs9467711 0.606 rs12174602 chr6:26372827 C/T cg06606381 chr12:133084897 FBRSL1 -0.75 -6.75 -0.38 9.06e-11 Autism spectrum disorder or schizophrenia; CESC cis rs854765 0.604 rs12948749 chr17:17949802 G/A cg16928487 chr17:17741425 SREBF1 0.59 10.2 0.53 8.07e-21 Total body bone mineral density; CESC trans rs9325144 0.647 rs17518186 chr12:38883665 T/C cg23762105 chr12:34175262 ALG10 0.46 6.05 0.35 4.84e-9 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs9300255 0.596 rs4460848 chr12:123677810 A/G cg05973401 chr12:123451056 ABCB9 0.46 5.75 0.33 2.41e-8 Neutrophil percentage of white cells; CESC cis rs6088590 0.523 rs6059913 chr20:33143288 G/A cg06115741 chr20:33292138 TP53INP2 0.51 6.54 0.37 3.21e-10 Coronary artery disease; CESC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.43e-28 Prudent dietary pattern; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg02737830 chr12:64616354 C12orf66 0.47 6.28 0.36 1.4e-9 Obesity-related traits; CESC cis rs6500395 1.000 rs871903 chr16:48593643 A/C cg04672837 chr16:48644449 N4BP1 0.51 6.36 0.36 8.56e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs11792861 0.816 rs113624314 chr9:111689953 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 6.62 0.38 1.96e-10 Menarche (age at onset); CESC cis rs7143963 0.609 rs57521303 chr14:103361937 T/C cg24154132 chr14:103367632 TRAF3 0.35 6.55 0.37 2.91e-10 Body mass index; CESC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg11905131 chr22:24372483 LOC391322 -0.73 -10.82 -0.55 7.99e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs17608059 0.518 rs4792436 chr17:13972307 T/A cg27005118 chr17:13972210 COX10 0.48 7.47 0.42 1.16e-12 Temperament; CESC cis rs317689 0.613 rs315112 chr12:69785926 T/A cg14784868 chr12:69753453 YEATS4 0.67 8.58 0.47 7.98e-16 Response to diuretic therapy; CESC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.87 9.04 0.49 3.44e-17 Platelet count; CESC cis rs9787249 0.957 rs3738673 chr1:40204823 C/T cg24920358 chr1:40204285 PPIE 0.43 6.47 0.37 4.74e-10 Blood protein levels; CESC cis rs11997175 0.603 rs66828270 chr8:33790155 C/G ch.8.33884649F chr8:33765107 NA 0.52 6.75 0.38 9.38e-11 Body mass index; CESC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs7236492 0.688 rs9709477 chr18:77202786 C/A cg15644404 chr18:77186268 NFATC1 -0.67 -5.26 -0.31 2.98e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.45 0.5 1.9e-18 Menopause (age at onset); CESC cis rs2404602 0.716 rs1874944 chr15:76863928 A/G cg22467129 chr15:76604101 ETFA -0.35 -5.24 -0.31 3.24e-7 Blood metabolite levels; CESC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg19046167 chr17:80928561 B3GNTL1 0.47 5.67 0.33 3.63e-8 Glycated hemoglobin levels; CESC cis rs13266463 0.830 rs6983790 chr8:143406575 A/G cg16886403 chr8:143471632 TSNARE1 0.43 5.28 0.31 2.66e-7 Schizophrenia; CESC cis rs6570726 1.000 rs1935617 chr6:145943326 C/T cg05347473 chr6:146136440 FBXO30 0.44 6.07 0.35 4.35e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg21724239 chr8:58056113 NA 0.56 5.9 0.34 1.1e-8 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06927217 chr1:149193722 NA -0.55 -6.88 -0.39 4.4e-11 Gut microbiome composition (summer); CESC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg18538332 chr22:24372958 LOC391322 0.71 10.37 0.54 2.28e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4144743 1.000 rs4144746 chr17:45323355 C/G cg18085866 chr17:45331354 ITGB3 -0.66 -7.64 -0.43 3.87e-13 Body mass index; CESC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg00684032 chr4:1343700 KIAA1530 0.36 5.45 0.32 1.15e-7 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27457105 chr17:36003574 DDX52 -0.61 -6.75 -0.38 9.13e-11 Gut microbiome composition (summer); CESC cis rs2430307 0.518 rs67763033 chr7:76517677 A/G cg15770687 chr7:76625569 PMS2L11 0.6 5.7 0.33 3.22e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs9815354 1.000 rs73079316 chr3:41863859 G/A cg03022575 chr3:42003672 ULK4 0.58 5.99 0.35 6.78e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg22920501 chr2:26401640 FAM59B -0.91 -10.33 -0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg07332563 chr6:291687 DUSP22 -0.66 -8.36 -0.46 3.52e-15 Menopause (age at onset); CESC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg26343298 chr8:95960752 TP53INP1 0.34 5.66 0.33 3.92e-8 Type 2 diabetes; CESC cis rs4523957 0.523 rs2760746 chr17:2034806 G/C cg16513277 chr17:2031491 SMG6 -0.78 -11.57 -0.58 2.42e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.22 -0.31 3.56e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs5769707 0.967 rs17182154 chr22:49990470 A/G cg20744362 chr22:50050164 C22orf34 0.42 7.17 0.4 7.46e-12 Monocyte count;Monocyte percentage of white cells; CESC cis rs10992471 0.729 rs7042335 chr9:95122547 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -5.62 -0.33 4.71e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC trans rs208520 0.507 rs7755710 chr6:66783355 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -22.35 -0.81 6.49e-63 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03712758 chr16:48400154 SIAH1 -0.66 -7.28 -0.41 3.79e-12 Gut microbiome composition (summer); CESC cis rs3105593 1.000 rs3105591 chr15:50869042 C/T cg08437265 chr15:50716283 USP8 0.4 5.28 0.31 2.71e-7 QT interval; CESC cis rs9399135 0.967 rs2150681 chr6:135375232 A/G cg22676075 chr6:135203613 NA -0.49 -6.77 -0.38 8.35e-11 Red blood cell count; CESC cis rs477692 0.699 rs471390 chr10:131382825 A/G cg05714579 chr10:131428358 MGMT -0.41 -5.36 -0.31 1.84e-7 Response to temozolomide; CESC cis rs1005224 1.000 rs1005224 chr14:76173860 A/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.4 -5.45 -0.32 1.17e-7 Large artery stroke; CESC cis rs1348850 0.645 rs10181259 chr2:178428256 C/A cg22681709 chr2:178499509 PDE11A -0.5 -6.34 -0.36 9.61e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7100689 0.622 rs10887798 chr10:82131613 G/A cg00277334 chr10:82204260 NA -0.58 -7.63 -0.42 4.2e-13 Post bronchodilator FEV1; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17014947 chr15:35529521 LOC723972 -0.48 -6.45 -0.37 5.39e-10 Gut microbiota (bacterial taxa); CESC trans rs9951602 0.512 rs8098115 chr18:76653986 G/T cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs7927592 0.673 rs498782 chr11:68275851 A/G cg16797656 chr11:68205561 LRP5 0.49 7.52 0.42 8.77e-13 Total body bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02835036 chr3:58318399 PXK 0.47 6.4 0.37 7.16e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs78456975 0.527 rs11901028 chr2:1557972 A/G cg26248373 chr2:1572462 NA -0.57 -6.87 -0.39 4.63e-11 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs524023 0.874 rs7105665 chr11:64396568 T/C cg07220939 chr11:64358617 SLC22A12 -0.36 -5.45 -0.32 1.17e-7 Urate levels in obese individuals; CESC cis rs36051895 0.659 rs1576271 chr9:5039652 A/C cg02405213 chr9:5042618 JAK2 -0.43 -5.2 -0.3 4.06e-7 Pediatric autoimmune diseases; CESC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg18876405 chr7:65276391 NA -0.54 -7.7 -0.43 2.66e-13 Aortic root size; CESC cis rs3741404 0.574 rs638227 chr11:63871549 T/C cg18225595 chr11:63971243 STIP1 0.5 6.59 0.38 2.39e-10 Platelet count; CESC cis rs7246657 0.943 rs10405325 chr19:37883477 G/C cg23950597 chr19:37808831 NA -0.61 -6.2 -0.36 2.21e-9 Coronary artery calcification; CESC cis rs9916302 0.904 rs11078910 chr17:37671269 G/T cg07936489 chr17:37558343 FBXL20 -0.81 -12.09 -0.6 4.18e-27 Glomerular filtration rate (creatinine); CESC cis rs959260 1.000 rs2053157 chr17:73378595 A/T cg12999837 chr17:73267436 MIF4GD -0.51 -5.85 -0.34 1.48e-8 Systemic lupus erythematosus; CESC cis rs7336332 0.547 rs9581859 chr13:28035147 A/T cg01674679 chr13:27998804 GTF3A -0.66 -5.25 -0.31 3.11e-7 Weight; CESC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.54 0.32 7.11e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2011503 0.941 rs55765017 chr19:19368264 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.5 5.06 0.3 7.87e-7 Bipolar disorder; CESC cis rs7659604 1.000 rs7659604 chr4:122665514 A/G cg19671926 chr4:122722719 EXOSC9 0.48 5.95 0.34 8.57e-9 Type 2 diabetes; CESC cis rs3733585 0.578 rs4466042 chr4:9955367 T/C cg02734326 chr4:10020555 SLC2A9 -0.4 -5.77 -0.33 2.19e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8141529 0.584 rs58004020 chr22:29257050 A/T cg15103426 chr22:29168792 CCDC117 0.67 9.52 0.5 1.15e-18 Lymphocyte counts; CESC cis rs1707322 0.963 rs6690652 chr1:46376692 G/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02072376 chr1:153606637 C1orf77;S100A13 -0.44 -6.26 -0.36 1.52e-9 Gut microbiota (bacterial taxa); CESC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg13206674 chr6:150067644 NUP43 0.43 5.69 0.33 3.4e-8 Lung cancer; CESC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg06221963 chr1:154839813 KCNN3 -0.66 -11.27 -0.57 2.55e-24 Prostate cancer; CESC cis rs10899021 0.790 rs59958321 chr11:74354614 G/A cg25880958 chr11:74394337 NA -0.76 -7.88 -0.44 8.55e-14 Response to metformin (IC50); CESC cis rs1144333 1.000 rs2202019 chr1:76299181 G/A cg10523679 chr1:76189770 ACADM 0.56 5.28 0.31 2.65e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs9393777 0.623 rs16891717 chr6:26477143 T/A cg14345882 chr6:26364793 BTN3A2 0.43 5.34 0.31 2.01e-7 Intelligence (multi-trait analysis); CESC trans rs1814175 0.715 rs10839409 chr11:49884647 G/T cg15704280 chr7:45808275 SEPT13 -1.03 -20.73 -0.79 2.07e-57 Height; CESC cis rs3008870 1.000 rs2065001 chr1:67486509 C/G cg08660285 chr1:67390436 MIER1;WDR78 1.02 13.47 0.64 7.49e-32 Lymphocyte percentage of white cells; CESC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.13 -0.35 3.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6674176 0.628 rs4660759 chr1:44432500 C/G cg12908607 chr1:44402522 ARTN -0.49 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs11958404 0.860 rs56090852 chr5:157431120 A/G cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg05368731 chr17:41323189 NBR1 0.76 10.35 0.54 2.73e-21 Menopause (age at onset); CESC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg11644478 chr21:40555479 PSMG1 1.05 16.84 0.72 9.02e-44 Cognitive function; CESC cis rs17376456 0.825 rs10075217 chr5:93176774 C/G cg21475434 chr5:93447410 FAM172A 0.75 6.68 0.38 1.38e-10 Diabetic retinopathy; CESC cis rs3026101 0.671 rs8076560 chr17:5299527 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12548629 chr7:92463334 CDK6 -0.48 -6.41 -0.37 6.77e-10 Asthma; CESC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg25767906 chr1:53392781 SCP2 -0.46 -6.01 -0.35 6.16e-9 Monocyte count; CESC cis rs12458462 0.892 rs2007483 chr18:77476131 A/T cg23301140 chr18:77439876 CTDP1 0.57 7.75 0.43 2.02e-13 Monocyte count; CESC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.35 5.64 0.33 4.24e-8 Personality dimensions; CESC cis rs2243480 1.000 rs1392104 chr7:65759107 G/A cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs8067354 0.645 rs2645492 chr17:57875554 A/G cg02344993 chr17:57696989 CLTC -0.55 -6.01 -0.35 6.27e-9 Hemoglobin concentration; CESC cis rs6582630 0.555 rs10880611 chr12:38509316 C/G cg26384229 chr12:38710491 ALG10B 0.7 10.5 0.54 8.9e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs12618769 0.597 rs3769713 chr2:99151434 A/G cg10123293 chr2:99228465 UNC50 0.4 5.23 0.31 3.4e-7 Bipolar disorder; CESC cis rs7666738 0.830 rs1593573 chr4:98925293 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15894619 chr12:56993036 BAZ2A 0.52 6.05 0.35 4.87e-9 Ulcerative colitis; CESC cis rs7071206 0.740 rs2048781 chr10:79422975 T/C cg00983440 chr10:79422392 NA -0.66 -8.01 -0.44 3.62e-14 Bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18342900 chr16:46865048 C16orf87 -0.44 -6.26 -0.36 1.53e-9 Gambling; CESC cis rs68170813 0.559 rs2299422 chr7:106959832 A/T cg02696742 chr7:106810147 HBP1 -0.53 -5.04 -0.3 8.64e-7 Coronary artery disease; CESC cis rs16854884 0.545 rs7650459 chr3:143658934 C/G cg01302019 chr3:143689584 C3orf58 -0.35 -5.53 -0.32 7.68e-8 Economic and political preferences (feminism/equality); CESC cis rs7089973 0.604 rs2420066 chr10:116583897 A/G cg03647239 chr10:116582469 FAM160B1 0.42 5.13 0.3 5.48e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs3768617 0.510 rs10797851 chr1:183098001 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs962856 0.619 rs4671795 chr2:67567068 A/G cg09028215 chr2:67624308 ETAA1 -0.44 -5.29 -0.31 2.58e-7 Pancreatic cancer; CESC cis rs2760061 0.819 rs1745417 chr1:228204279 C/T cg18477163 chr1:228402036 OBSCN 0.33 5.77 0.33 2.23e-8 Diastolic blood pressure; CESC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg17372223 chr3:52568218 NT5DC2 0.44 6.64 0.38 1.8e-10 Bipolar disorder; CESC cis rs4660261 0.526 rs3011228 chr1:44325995 A/G cg12908607 chr1:44402522 ARTN -0.45 -6.39 -0.37 7.55e-10 Intelligence (multi-trait analysis); CESC cis rs2251381 0.606 rs8129515 chr21:30520167 C/G cg08807101 chr21:30365312 RNF160 0.68 8.58 0.47 8.18e-16 Selective IgA deficiency; CESC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg08736216 chr1:53307985 ZYG11A 0.32 5.53 0.32 7.58e-8 Monocyte count; CESC cis rs7824557 0.767 rs11250127 chr8:11170209 G/A cg21775007 chr8:11205619 TDH 0.47 6.95 0.39 2.85e-11 Retinal vascular caliber; CESC cis rs7336332 0.569 rs7988412 chr13:28000282 C/T cg01674679 chr13:27998804 GTF3A -0.64 -6.18 -0.36 2.39e-9 Weight; CESC cis rs9318086 0.753 rs9553094 chr13:24474613 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.43 -6.39 -0.37 7.37e-10 Myopia (pathological); CESC cis rs2439831 1.000 rs2467736 chr15:43784917 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.83 11.92 0.59 1.68e-26 Lung cancer in ever smokers; CESC cis rs6976053 0.564 rs314347 chr7:100399149 G/A cg03098644 chr7:100410630 EPHB4 -0.46 -5.84 -0.34 1.54e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 5.08 0.3 7.22e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg18479299 chr3:125709523 NA -0.49 -5.19 -0.3 4.16e-7 Blood pressure (smoking interaction); CESC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg27170947 chr2:26402098 FAM59B -0.59 -7.07 -0.4 1.36e-11 Gut microbiome composition (summer); CESC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg23590916 chr17:43697445 MGC57346 0.65 6.44 0.37 5.62e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1568889 1.000 rs16917735 chr11:28119980 A/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.72 -9.21 -0.49 1.05e-17 Bipolar disorder; CESC cis rs3008870 1.000 rs35365746 chr1:67438900 G/A cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -14.53 -0.67 1.38e-35 Lymphocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06111305 chr13:98086784 RAP2A -0.46 -6.04 -0.35 5.07e-9 Gut microbiota (bacterial taxa); CESC cis rs2425143 0.822 rs6060677 chr20:34499368 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.75 6.96 0.39 2.69e-11 Blood protein levels; CESC cis rs524281 0.861 rs10896094 chr11:65959206 C/T cg14036092 chr11:66035641 RAB1B -0.59 -6.13 -0.35 3.24e-9 Electroencephalogram traits; CESC cis rs3096299 0.967 rs7205785 chr16:89458984 A/G cg08822215 chr16:89438651 ANKRD11 -0.41 -6.28 -0.36 1.38e-9 Multiple myeloma (IgH translocation); CESC cis rs12142240 0.698 rs6697123 chr1:46811310 A/C cg00530320 chr1:46809349 NSUN4 0.58 7.85 0.43 1.05e-13 Menopause (age at onset); CESC cis rs12765878 1.000 rs2067832 chr10:105643134 G/A cg11005552 chr10:105648138 OBFC1 0.36 5.29 0.31 2.51e-7 Coronary artery disease; CESC cis rs2204008 0.775 rs11182513 chr12:38560252 G/C cg26384229 chr12:38710491 ALG10B 0.76 11.63 0.58 1.62e-25 Bladder cancer; CESC cis rs9303401 0.614 rs3803752 chr17:56540267 C/T cg25039879 chr17:56429692 SUPT4H1 0.53 5.14 0.3 5.32e-7 Cognitive test performance; CESC cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.65 0.61 5.23e-29 Colonoscopy-negative controls vs population controls; CESC cis rs7216064 0.953 rs12601759 chr17:65955284 A/G cg12091567 chr17:66097778 LOC651250 -0.7 -7.16 -0.4 7.85e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs8060686 0.641 rs7192187 chr16:68132109 T/C cg26727032 chr16:67993705 SLC12A4 -0.52 -6.33 -0.36 1.05e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs7584330 0.740 rs11896232 chr2:238438124 T/C cg14458575 chr2:238380390 NA 0.51 7.64 0.42 3.95e-13 Prostate cancer; CESC cis rs10782582 0.593 rs4646960 chr1:76211103 C/A cg10523679 chr1:76189770 ACADM -0.48 -5.59 -0.32 5.59e-8 Daytime sleep phenotypes; CESC trans rs17181170 0.666 rs6801665 chr3:87209149 T/C ch.2.199792288R chr2:200084043 NA -0.48 -6.23 -0.36 1.82e-9 Prostate cancer; CESC cis rs7914558 1.000 rs7081075 chr10:104929191 C/T cg04362960 chr10:104952993 NT5C2 0.47 6.21 0.36 2e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg21782813 chr7:2030301 MAD1L1 -0.4 -5.57 -0.32 6.23e-8 Bipolar disorder and schizophrenia; CESC cis rs28489187 0.660 rs4949900 chr1:85861034 T/G cg16011679 chr1:85725395 C1orf52 -0.44 -5.24 -0.31 3.36e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg07677032 chr17:61819896 STRADA -0.48 -6.3 -0.36 1.21e-9 Prudent dietary pattern; CESC cis rs2228479 0.867 rs34604714 chr16:89948985 A/G cg14709524 chr16:89940631 TCF25 0.74 5.75 0.33 2.43e-8 Skin colour saturation; CESC cis rs116095464 0.558 rs73024831 chr5:257192 A/G cg22496380 chr5:211416 CCDC127 -0.73 -8.39 -0.46 2.99e-15 Breast cancer; CESC cis rs12477438 0.798 rs6736064 chr2:99658201 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11216682 chr2:131113867 PTPN18 0.54 6.55 0.37 2.9e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10480950 chr6:5067127 NA -0.6 -7.16 -0.4 8.19e-12 Gut microbiome composition (summer); CESC cis rs9487051 0.652 rs9372210 chr6:109601703 G/C cg12927641 chr6:109611667 NA -0.36 -5.24 -0.31 3.24e-7 Reticulocyte fraction of red cells; CESC cis rs910316 0.699 rs175039 chr14:75468950 G/C cg11812906 chr14:75593930 NEK9 -0.8 -12.67 -0.61 4.38e-29 Height; CESC cis rs1707322 0.827 rs10890347 chr1:46242332 A/T cg03146154 chr1:46216737 IPP -0.78 -10.48 -0.54 1.02e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.95 10.19 0.53 8.92e-21 Platelet count; CESC cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg22834771 chr12:69754056 YEATS4 -0.46 -6.2 -0.36 2.17e-9 Blood protein levels; CESC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg18301423 chr5:131593218 PDLIM4 0.38 5.24 0.31 3.27e-7 Acylcarnitine levels; CESC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg25985355 chr7:65971099 NA -0.32 -5.28 -0.31 2.71e-7 Aortic root size; CESC cis rs941873 0.868 rs4980063 chr10:81105844 A/T cg11057378 chr10:81107060 PPIF 0.32 5.15 0.3 5.12e-7 Height; CESC cis rs7264396 0.836 rs6058282 chr20:34212590 T/G cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.48 0.42 1.06e-12 Total cholesterol levels; CESC cis rs2046867 0.908 rs1106310 chr3:72818902 A/T cg25664220 chr3:72788482 NA 0.45 6.94 0.39 2.92e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs9581857 0.547 rs4612914 chr13:28049128 A/G cg01674679 chr13:27998804 GTF3A -0.68 -5.47 -0.32 1.04e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs524281 0.731 rs11227433 chr11:66004693 G/A cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.28e-7 Electroencephalogram traits; CESC cis rs1707322 1.000 rs10890382 chr1:46469674 A/G cg06784218 chr1:46089804 CCDC17 0.38 6.42 0.37 6.22e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs67311347 1.000 rs9882171 chr3:40518821 G/A cg09455208 chr3:40491958 NA 0.48 8.36 0.46 3.68e-15 Renal cell carcinoma; CESC cis rs6840360 0.554 rs61308159 chr4:152728941 G/A cg22705602 chr4:152727874 NA 0.37 5.07 0.3 7.32e-7 Intelligence (multi-trait analysis); CESC cis rs858239 0.669 rs10950940 chr7:23196816 C/T cg23682824 chr7:23144976 KLHL7 -0.43 -5.78 -0.33 2.05e-8 Cerebrospinal fluid biomarker levels; CESC cis rs965469 1.000 rs77763497 chr20:3250007 A/G cg25506879 chr20:3388711 C20orf194 -0.62 -6.55 -0.37 3.01e-10 IFN-related cytopenia; CESC cis rs10771431 0.782 rs10771415 chr12:9358223 C/T cg08997352 chr12:9597637 DDX12 -0.76 -10.48 -0.54 1.01e-21 Breast size; CESC cis rs6089584 0.924 rs6142906 chr20:60552554 G/C cg24733560 chr20:60626293 TAF4 0.42 6.06 0.35 4.61e-9 Body mass index; CESC cis rs12477438 0.520 rs11685759 chr2:99766217 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 16.02 0.7 7.14e-41 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01989157 chr22:40742702 ADSL -0.63 -7.47 -0.42 1.16e-12 Gut microbiome composition (summer); CESC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg16145915 chr7:1198662 ZFAND2A -0.61 -9.12 -0.49 1.96e-17 Longevity;Endometriosis; CESC cis rs9987353 0.519 rs2929465 chr8:9064002 C/G cg15556689 chr8:8085844 FLJ10661 -0.46 -5.54 -0.32 7.43e-8 Recombination measurement; CESC cis rs3733585 0.699 rs7435196 chr4:9967556 A/C cg00071950 chr4:10020882 SLC2A9 -0.7 -11.56 -0.58 2.67e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs763121 0.819 rs5750629 chr22:38985065 T/C cg06544989 chr22:39130855 UNC84B 0.5 9.21 0.49 1e-17 Menopause (age at onset); CESC cis rs1062177 1.000 rs12515762 chr5:151209922 G/T cg12924095 chr5:151150029 G3BP1 0.5 6.48 0.37 4.55e-10 Preschool internalizing problems; CESC cis rs2777491 0.522 rs7173571 chr15:41712807 T/C cg18705301 chr15:41695430 NDUFAF1 -0.55 -7.63 -0.42 4.24e-13 Ulcerative colitis; CESC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 12.92 0.62 6.19e-30 Personality dimensions; CESC cis rs6963495 0.769 rs73192134 chr7:105189338 T/C cg02135003 chr7:105160482 PUS7 -0.46 -5.48 -0.32 1.01e-7 Bipolar disorder (body mass index interaction); CESC cis rs9815354 0.812 rs73083333 chr3:41927505 G/A cg03022575 chr3:42003672 ULK4 0.71 6.39 0.37 7.39e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs2929278 0.546 rs686666 chr15:44161550 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.49 7.63 0.42 4.13e-13 Schizophrenia; CESC cis rs12477438 0.798 rs13414153 chr2:99624748 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.91 -0.48 8.52e-17 Chronic sinus infection; CESC cis rs763121 0.853 rs2413544 chr22:39059404 A/C cg14440974 chr22:39074834 NA -0.4 -5.5 -0.32 9.03e-8 Menopause (age at onset); CESC cis rs72387598 1 rs72387598 chr1:45922977 CAT/C cg03146154 chr1:46216737 IPP 0.47 5.44 0.32 1.23e-7 Platelet distribution width; CESC cis rs3733585 0.604 rs73215003 chr4:10126317 C/G cg00071950 chr4:10020882 SLC2A9 -0.66 -10.48 -0.54 9.69e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs870825 0.616 rs4519834 chr4:185633865 A/G cg04058563 chr4:185651563 MLF1IP -0.67 -7.35 -0.41 2.41e-12 Blood protein levels; CESC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs61931739 0.500 rs34703942 chr12:34583776 T/C cg23762105 chr12:34175262 ALG10 0.4 5.17 0.3 4.62e-7 Morning vs. evening chronotype; CESC cis rs4660261 0.526 rs3094954 chr1:44320919 C/T cg13606994 chr1:44402422 ARTN -0.35 -5.14 -0.3 5.31e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg01171360 chr6:293285 DUSP22 0.66 8.66 0.47 4.7e-16 Menopause (age at onset); CESC trans rs116095464 0.558 rs6872854 chr5:209038 G/T cg00938859 chr5:1591904 SDHAP3 0.6 6.68 0.38 1.41e-10 Breast cancer; CESC cis rs7917772 0.636 rs4418737 chr10:104525123 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -5.18 -0.3 4.3e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7523050 0.643 rs7519293 chr1:109399543 A/G cg08274380 chr1:109419600 GPSM2 0.83 5.58 0.32 5.89e-8 Fat distribution (HIV); CESC cis rs651907 0.514 rs55654108 chr3:101425703 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.9 0.34 1.1e-8 Colorectal cancer; CESC cis rs7582720 1.000 rs35212307 chr2:203765756 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs9788682 0.792 rs35031105 chr15:78772806 C/T cg24631222 chr15:78858424 CHRNA5 0.62 7.27 0.41 3.96e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs2243480 1.000 rs313814 chr7:65503293 C/A cg18252515 chr7:66147081 NA -1.29 -12.65 -0.61 5.36e-29 Diabetic kidney disease; CESC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg07308232 chr7:1071921 C7orf50 -0.6 -8.54 -0.46 1.04e-15 Longevity;Endometriosis; CESC cis rs12681288 0.823 rs2701909 chr8:1003057 A/G cg04851639 chr8:1020857 NA -0.34 -7.49 -0.42 1e-12 Schizophrenia; CESC cis rs6963495 0.818 rs73192125 chr7:105175068 A/C cg13798780 chr7:105162888 PUS7 0.73 7.9 0.44 7.36e-14 Bipolar disorder (body mass index interaction); CESC trans rs6951245 0.554 rs75075857 chr7:1140298 C/T cg13565492 chr6:43139072 SRF -0.75 -9.29 -0.5 5.94e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7520050 0.933 rs6661163 chr1:46255004 A/G cg03146154 chr1:46216737 IPP -0.5 -6.78 -0.38 7.95e-11 Red blood cell count;Reticulocyte count; CESC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.43 0.32 1.24e-7 Bipolar disorder; CESC cis rs2243480 0.908 rs313822 chr7:65573939 G/A cg13147721 chr7:65941812 NA -0.99 -9.34 -0.5 4.25e-18 Diabetic kidney disease; CESC cis rs1568889 1.000 rs12287732 chr11:28120845 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 10.76 0.55 1.19e-22 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15454818 chr7:75932933 HSPB1 0.56 6.01 0.35 6.14e-9 Gut microbiome composition (summer); CESC cis rs858239 0.539 rs2141305 chr7:23191899 T/C cg23682824 chr7:23144976 KLHL7 0.51 6.77 0.38 8.05e-11 Cerebrospinal fluid biomarker levels; CESC trans rs12615721 0.786 rs60344971 chr2:81948537 C/T cg13174197 chr3:52720522 GNL3;PBRM1 0.78 6.3 0.36 1.22e-9 Pulmonary function decline; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11789684 chr7:141251045 AGK 0.56 6.45 0.37 5.3e-10 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg27099511 chr16:88729703 MGC23284;MVD -0.52 -6.59 -0.38 2.38e-10 Asthma; CESC cis rs2012796 0.956 rs7146802 chr14:81820515 A/G cg02996355 chr14:81879375 NA 0.53 6.15 0.35 2.91e-9 Night sleep phenotypes; CESC cis rs7527798 0.592 rs6667118 chr1:207822724 G/T cg21110645 chr1:207815933 NA -0.33 -5.94 -0.34 9.12e-9 Erythrocyte sedimentation rate; CESC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg13628971 chr7:2884303 GNA12 0.63 8.33 0.46 4.4e-15 Height; CESC cis rs367943 0.698 rs2900074 chr5:113000374 A/C cg12552261 chr5:112820674 MCC 0.46 5.88 0.34 1.26e-8 Type 2 diabetes; CESC cis rs2204008 0.744 rs12099650 chr12:38317140 C/G cg26384229 chr12:38710491 ALG10B 0.66 9.82 0.52 1.26e-19 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22914762 chr4:117220908 MIR1973 -0.6 -7.48 -0.42 1.09e-12 Gut microbiome composition (summer); CESC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg23131131 chr22:24373011 LOC391322 -0.63 -9.02 -0.48 3.88e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg11707556 chr5:10655725 ANKRD33B 0.43 6.12 0.35 3.43e-9 Height; CESC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs933688 1.000 rs11950530 chr5:90688740 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.87 0.59 2.36e-26 Smoking behavior; CESC cis rs10880689 1 rs10880689 chr12:37930102 A/G cg26384229 chr12:38710491 ALG10B 0.67 9.69 0.51 3.43e-19 Resting heart rate; CESC cis rs5769765 0.671 rs138841 chr22:50181960 C/A cg02269571 chr22:50332266 NA -0.46 -5.94 -0.34 9.04e-9 Schizophrenia; CESC cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg03467027 chr4:99064603 C4orf37 0.45 5.67 0.33 3.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg14926445 chr8:58193284 C8orf71 -0.53 -5.61 -0.33 5.1e-8 Developmental language disorder (linguistic errors); CESC cis rs896854 0.902 rs726816 chr8:95968413 T/G cg16049864 chr8:95962084 TP53INP1 -0.69 -11.99 -0.59 9.66e-27 Type 2 diabetes; CESC trans rs747782 0.527 rs12289516 chr11:48234680 G/A cg15704280 chr7:45808275 SEPT13 0.71 6.65 0.38 1.68e-10 Intraocular pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16224671 chr7:23146217 KLHL7 -0.5 -6.06 -0.35 4.73e-9 Gut microbiome composition (summer); CESC cis rs9583531 0.657 rs7318291 chr13:111352460 C/T cg15841412 chr13:111365552 ING1 -0.43 -5.18 -0.3 4.32e-7 Coronary artery disease; CESC cis rs12136530 0.774 rs4912095 chr1:19766236 T/C cg01832549 chr1:19774989 CAPZB -0.48 -6.66 -0.38 1.54e-10 Lead levels in blood; CESC cis rs939574 1.000 rs11552796 chr2:220108300 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.84 7.22 0.41 5.65e-12 Platelet distribution width; CESC cis rs7259376 0.936 rs1975173 chr19:22534538 C/G cg02657401 chr19:22469223 NA -0.27 -5.21 -0.3 3.74e-7 Menopause (age at onset); CESC cis rs11792861 0.591 rs4978763 chr9:111728067 C/T cg05043794 chr9:111880884 C9orf5 -0.31 -5.65 -0.33 4.22e-8 Menarche (age at onset); CESC cis rs10771431 0.935 rs1117735 chr12:9372728 G/A cg00504896 chr12:9437009 LOC642846 -0.41 -5.49 -0.32 9.33e-8 Breast size; CESC cis rs8017423 0.904 rs11623741 chr14:90804474 C/T cg14092571 chr14:90743983 NA -0.57 -8.94 -0.48 7.01e-17 Mortality in heart failure; CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.62 8.59 0.47 7.71e-16 Bipolar disorder; CESC cis rs10129255 0.509 rs756583 chr14:107136019 C/T cg23076370 chr14:107095027 NA -0.53 -7.45 -0.42 1.34e-12 Kawasaki disease; CESC cis rs7512552 0.839 rs834229 chr1:150384665 G/C cg15654264 chr1:150340011 RPRD2 0.4 5.2 0.3 4.06e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg18876405 chr7:65276391 NA 0.45 6.09 0.35 3.92e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17478615 chr1:185285364 IVNS1ABP 0.64 7.75 0.43 1.95e-13 Gut microbiome composition (summer); CESC cis rs9359856 0.564 rs1036853 chr6:90499502 G/A cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.94 -0.34 8.89e-9 Bipolar disorder; CESC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.24 0.41 4.89e-12 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01390039 chr16:89315293 NA 0.49 6.32 0.36 1.1e-9 Fibrinogen levels; CESC cis rs1784581 0.569 rs9364629 chr6:162416831 T/G cg17173639 chr6:162384350 PARK2 0.56 8.43 0.46 2.21e-15 Itch intensity from mosquito bite; CESC cis rs4727027 0.901 rs10952792 chr7:148760501 C/T cg23583168 chr7:148888333 NA -0.77 -11.6 -0.58 1.95e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11098499 0.866 rs12374244 chr4:120281972 A/T cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs826838 1.000 rs10880963 chr12:38748408 T/C cg13010199 chr12:38710504 ALG10B 0.62 8.74 0.47 2.7e-16 Heart rate; CESC cis rs4889855 0.530 rs75398920 chr17:78544540 C/T cg16591659 chr17:78472290 NA 0.39 6.5 0.37 3.9e-10 Fractional excretion of uric acid; CESC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.78 0.38 7.94e-11 Bipolar disorder; CESC cis rs548181 0.611 rs562599 chr11:125459951 A/C cg03464685 chr11:125439445 EI24 1.24 9.77 0.51 1.89e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg21573476 chr21:45109991 RRP1B -0.58 -8.43 -0.46 2.18e-15 Mean corpuscular volume; CESC cis rs3741151 0.773 rs57354084 chr11:73139376 A/T cg17517138 chr11:73019481 ARHGEF17 0.94 6.86 0.39 4.87e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs17508449 0.819 rs78394484 chr1:114282758 T/C cg23028848 chr11:57092561 TNKS1BP1 -0.76 -6.07 -0.35 4.52e-9 Leprosy; CESC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg23281280 chr6:28129359 ZNF389 0.44 6.46 0.37 5.1e-10 Parkinson's disease; CESC cis rs2299587 0.527 rs7818801 chr8:17722867 G/C cg08627089 chr8:17753878 FGL1 -0.39 -5.57 -0.32 6.35e-8 Economic and political preferences; CESC cis rs6964587 1.000 rs10263309 chr7:91645265 A/G cg17063962 chr7:91808500 NA 0.57 7.92 0.44 6.39e-14 Breast cancer; CESC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg03709012 chr19:19516395 GATAD2A 0.96 14.18 0.66 2.35e-34 Tonsillectomy; CESC cis rs7070678 0.662 rs913035 chr10:29818604 A/C cg12329853 chr10:29834266 MIR604;SVIL -0.38 -5.26 -0.31 3.03e-7 Platelet thrombus formation; CESC cis rs6541297 0.793 rs6692319 chr1:230284375 C/T cg20703242 chr1:230279135 GALNT2 0.74 11.07 0.56 1.18e-23 Coronary artery disease; CESC cis rs72781680 1.000 rs6710426 chr2:24159288 A/G cg08917208 chr2:24149416 ATAD2B 0.94 8.66 0.47 4.66e-16 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27115721 chr2:16790338 FAM49A 0.57 6.09 0.35 3.97e-9 Gut microbiome composition (summer); CESC cis rs6545883 0.929 rs10190332 chr2:61619267 T/G cg15711740 chr2:61764176 XPO1 0.39 5.03 0.3 9.02e-7 Tuberculosis; CESC cis rs4812048 0.649 rs6070705 chr20:57625231 A/C cg14073986 chr20:57617431 SLMO2 0.84 7.18 0.4 6.92e-12 Mean platelet volume; CESC cis rs17407555 0.779 rs57757169 chr4:10115703 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -5.87 -0.34 1.29e-8 Schizophrenia (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17086759 chr4:6303693 WFS1 0.49 6.35 0.36 9.32e-10 Fibrinogen levels; CESC cis rs17376456 0.825 rs10072232 chr5:93398890 G/A cg21475434 chr5:93447410 FAM172A 0.79 6.99 0.39 2.2e-11 Diabetic retinopathy; CESC cis rs6815814 0.950 rs66979032 chr4:38814700 A/G cg02016764 chr4:38805732 TLR1 -0.57 -6.5 -0.37 4.05e-10 Breast cancer; CESC cis rs13095912 0.778 rs11914529 chr3:185296513 C/T cg11274856 chr3:185301563 NA 0.39 5.86 0.34 1.4e-8 Systolic blood pressure; CESC cis rs523516 0.645 rs520054 chr17:37321538 G/A cg20555674 chr17:37321631 ARL5C 0.37 6.32 0.36 1.1e-9 IgG glycosylation; CESC cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg10556349 chr10:835070 NA 0.59 5.6 0.33 5.25e-8 Eosinophil percentage of granulocytes; CESC cis rs9583531 0.600 rs7984468 chr13:111362093 C/A cg24331049 chr13:111365604 ING1 0.75 10.98 0.56 2.28e-23 Coronary artery disease; CESC cis rs1568889 0.838 rs7121937 chr11:28359858 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 13.71 0.64 1.11e-32 Bipolar disorder; CESC cis rs7267979 1.000 rs6050590 chr20:25384994 G/A cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.85e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs79976124 0.837 rs10498840 chr6:66658513 A/G cg07460842 chr6:66804631 NA 0.78 9.08 0.49 2.57e-17 Type 2 diabetes; CESC cis rs910316 0.935 rs3742771 chr14:75599647 A/G cg08847533 chr14:75593920 NEK9 0.99 18.93 0.76 3.76e-51 Height; CESC cis rs7143963 0.666 rs57613851 chr14:103319835 C/T cg24154132 chr14:103367632 TRAF3 0.3 5.55 0.32 6.91e-8 Body mass index; CESC cis rs6424115 0.830 rs2502991 chr1:24202318 A/G cg10978503 chr1:24200527 CNR2 0.33 6.59 0.38 2.41e-10 Immature fraction of reticulocytes; CESC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7789940 1.000 rs76024966 chr7:75995021 C/T cg10167463 chr7:75959203 YWHAG -0.55 -6.81 -0.39 6.33e-11 Multiple sclerosis; CESC cis rs7103648 0.695 rs10838726 chr11:47568344 C/G cg10504702 chr11:47789108 FNBP4 0.42 5.2 0.3 4.01e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs3820928 0.874 rs4675128 chr2:227814757 T/C cg05526886 chr2:227700861 RHBDD1 -0.44 -5.68 -0.33 3.56e-8 Pulmonary function; CESC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg21433313 chr16:3507492 NAT15 0.68 8.36 0.46 3.49e-15 Tuberculosis; CESC cis rs4728302 0.583 rs1424583 chr7:133159583 T/G cg10665199 chr7:133106180 EXOC4 0.54 7.47 0.42 1.17e-12 Intelligence;Intelligence (multi-trait analysis); CESC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg19717773 chr7:2847554 GNA12 -0.48 -7.01 -0.4 1.97e-11 Height; CESC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg21984481 chr17:79567631 NPLOC4 -0.33 -5.17 -0.3 4.68e-7 Eye color traits; CESC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg04414720 chr1:150670196 GOLPH3L 0.58 8.15 0.45 1.42e-14 Tonsillectomy; CESC cis rs796364 1.000 rs35220450 chr2:200780737 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.83 -6.41 -0.37 6.49e-10 Schizophrenia; CESC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg24399712 chr22:39784796 NA -0.83 -11.67 -0.58 1.15e-25 Intelligence (multi-trait analysis); CESC cis rs7666738 0.546 rs3911415 chr4:98692401 T/A cg05340658 chr4:99064831 C4orf37 0.55 6.57 0.37 2.6e-10 Colonoscopy-negative controls vs population controls; CESC cis rs6939532 0.522 rs4712981 chr6:26361430 C/T cg14345882 chr6:26364793 BTN3A2 0.38 6.06 0.35 4.64e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg13877915 chr19:58951672 ZNF132 0.39 5.8 0.34 1.84e-8 Uric acid clearance; CESC cis rs8060686 0.565 rs8057577 chr16:68033143 C/T cg26727032 chr16:67993705 SLC12A4 -0.52 -5.78 -0.33 2.09e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg15556689 chr8:8085844 FLJ10661 0.53 6.45 0.37 5.3e-10 Mood instability; CESC cis rs7586879 0.616 rs6545813 chr2:25131287 C/T cg01884057 chr2:25150051 NA 0.36 7.02 0.4 1.82e-11 Body mass index; CESC cis rs7107174 0.681 rs10899499 chr11:78124797 A/G cg02023728 chr11:77925099 USP35 -0.42 -5.55 -0.32 6.83e-8 Testicular germ cell tumor; CESC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg06484146 chr7:12443880 VWDE -0.78 -9.1 -0.49 2.28e-17 Coronary artery disease; CESC cis rs12122100 0.545 rs1984615 chr1:146506206 G/A cg02487331 chr1:146550467 NA -0.36 -5.46 -0.32 1.11e-7 HIV-1 control; CESC cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 7.23 0.41 5.16e-12 Personality dimensions; CESC cis rs4835473 0.868 rs62337291 chr4:144729056 G/A cg25736465 chr4:144833511 NA -0.33 -5.35 -0.31 1.92e-7 Immature fraction of reticulocytes; CESC cis rs7474896 0.559 rs1735629 chr10:38178309 C/T cg25427524 chr10:38739819 LOC399744 0.48 5.27 0.31 2.9e-7 Obesity (extreme); CESC cis rs870825 0.587 rs58332461 chr4:185639742 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg03467027 chr4:99064603 C4orf37 0.45 5.61 0.33 4.97e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17373321 chr8:21999250 REEP4 0.56 6.51 0.37 3.76e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg27170947 chr2:26402098 FAM59B 0.87 9.89 0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs72627123 0.656 rs17096208 chr14:74555269 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.74 5.12 0.3 5.89e-7 Morning vs. evening chronotype; CESC cis rs34779708 0.931 rs13376801 chr10:35370443 T/C cg03585969 chr10:35415529 CREM 0.76 10.09 0.53 1.8e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs1691799 0.836 rs1168334 chr12:66760972 A/G cg16791601 chr12:66731901 HELB -0.77 -13.33 -0.63 2.24e-31 White blood cell count (basophil); CESC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg14703610 chr5:56206110 C5orf35 0.4 5.1 0.3 6.49e-7 Coronary artery disease; CESC trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg15704280 chr7:45808275 SEPT13 0.85 13.86 0.65 3.28e-33 Coronary artery disease; CESC cis rs96067 0.711 rs11263861 chr1:36628033 G/A cg24686825 chr1:36642396 MAP7D1 -0.43 -5.93 -0.34 9.58e-9 Corneal structure; CESC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.07e-8 Lung cancer; CESC cis rs7551222 0.716 rs4245738 chr1:204506107 C/T cg20240347 chr1:204465584 NA -0.27 -5.53 -0.32 7.68e-8 Schizophrenia; CESC cis rs425277 1.000 rs809912 chr1:2078385 C/T cg16545954 chr1:2118288 C1orf86 0.33 5.6 0.33 5.35e-8 Height; CESC cis rs2070488 0.775 rs6599204 chr3:38525734 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.78 12.02 0.59 7.73e-27 Electrocardiographic conduction measures; CESC cis rs1878931 0.582 rs27231 chr16:3434966 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.66 8.06 0.44 2.66e-14 Body mass index (adult); CESC cis rs11997175 0.784 rs36083407 chr8:33812930 G/T ch.8.33884649F chr8:33765107 NA 0.65 9.1 0.49 2.22e-17 Body mass index; CESC cis rs7959452 0.535 rs1350166 chr12:69636314 G/T cg14784868 chr12:69753453 YEATS4 0.74 10.76 0.55 1.23e-22 Blood protein levels; CESC trans rs7839040 0.698 rs7836715 chr8:82928699 G/C cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14582245 chr3:42632291 SS18L2 0.54 6.27 0.36 1.43e-9 Gut microbiome composition (summer); CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg07507251 chr3:52567010 NT5DC2 0.54 11.16 0.57 5.94e-24 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04460668 chr12:122984780 ZCCHC8 -0.54 -6.39 -0.37 7.61e-10 Gut microbiome composition (summer); CESC cis rs11683229 0.704 rs4671454 chr2:63156832 T/G cg17519650 chr2:63277830 OTX1 -0.66 -5.51 -0.32 8.5e-8 Protein quantitative trait loci; CESC cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.46 7.64 0.42 3.98e-13 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03823722 chr10:3214957 PITRM1 0.58 6.53 0.37 3.38e-10 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17900697 chr17:27139003 C17orf63 0.46 6.3 0.36 1.25e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11792861 0.926 rs75128146 chr9:111833791 G/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 5.31 0.31 2.29e-7 Menarche (age at onset); CESC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg08736216 chr1:53307985 ZYG11A 0.43 7.13 0.4 9.53e-12 Monocyte count; CESC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.93 -13.38 -0.63 1.57e-31 Alzheimer's disease; CESC trans rs561341 0.941 rs17780086 chr17:30343282 G/A cg27661571 chr11:113659931 NA -0.85 -7.51 -0.42 9.26e-13 Hip circumference adjusted for BMI; CESC cis rs7582720 1.000 rs72934729 chr2:203737770 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18708365 chr7:103848079 ORC5L -0.59 -7.14 -0.4 8.82e-12 Gut microbiome composition (summer); CESC trans rs801193 0.901 rs4273746 chr7:66301111 C/T cg18876405 chr7:65276391 NA -0.67 -8.75 -0.47 2.48e-16 Aortic root size; CESC trans rs1977584 0.725 rs61853976 chr10:45399242 T/C cg09262100 chr14:103416268 CDC42BPB 0.61 6.14 0.35 3.02e-9 Selective IgA deficiency; CESC cis rs2439831 0.867 rs28729853 chr15:43673680 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.86 13.04 0.63 2.26e-30 Lung cancer in ever smokers; CESC cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.73 7.77 0.43 1.74e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6991838 0.550 rs4737750 chr8:66550959 G/C cg13398993 chr8:66546079 ARMC1 0.47 5.72 0.33 2.92e-8 Intelligence (multi-trait analysis); CESC cis rs7520050 0.898 rs34175029 chr1:46483871 C/T cg24296786 chr1:45957014 TESK2 0.44 5.48 0.32 1.01e-7 Red blood cell count;Reticulocyte count; CESC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg02569458 chr12:86230093 RASSF9 0.49 7.22 0.41 5.67e-12 Major depressive disorder; CESC cis rs754466 0.561 rs72806025 chr10:79707026 C/T cg17075019 chr10:79541650 NA -0.68 -6.32 -0.36 1.12e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9811920 0.809 rs1387647 chr3:99826942 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 7.33 0.41 2.78e-12 Axial length; CESC cis rs9443645 0.901 rs4706077 chr6:79548845 G/A cg05283184 chr6:79620031 NA -0.44 -6.84 -0.39 5.36e-11 Intelligence (multi-trait analysis); CESC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg05564831 chr3:52568323 NT5DC2 0.46 7.08 0.4 1.31e-11 Electroencephalogram traits; CESC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg07414643 chr4:187882934 NA 0.56 8.14 0.45 1.53e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs116095464 0.681 rs1574220 chr5:314518 T/C cg10591111 chr5:226296 SDHA -0.62 -5.95 -0.34 8.46e-9 Breast cancer; CESC cis rs887829 0.569 rs3806597 chr2:234637569 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.48 6.46 0.37 4.89e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs1451375 0.572 rs3807558 chr7:50571022 A/G cg14593290 chr7:50529359 DDC -0.52 -6.6 -0.38 2.18e-10 Malaria; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00177013 chr20:62339100 ARFRP1;ZGPAT 0.5 6.61 0.38 2.07e-10 Gut microbiota (bacterial taxa); CESC cis rs6540556 0.679 rs11808690 chr1:209891450 T/G cg05527609 chr1:210001259 C1orf107 -0.67 -7.35 -0.41 2.43e-12 Red blood cell count; CESC cis rs656900 0.967 rs661478 chr15:80115100 C/T cg02196730 chr15:80188777 MTHFS -0.4 -5.04 -0.3 8.75e-7 Cerebrospinal P-tau181p levels; CESC trans rs7824557 0.527 rs2572369 chr8:11238597 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -6.43 -0.37 5.8e-10 Retinal vascular caliber; CESC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg12463550 chr7:65579703 CRCP 0.56 7.3 0.41 3.42e-12 Aortic root size; CESC cis rs4888262 0.508 rs12598701 chr16:74539904 G/A cg01733217 chr16:74700730 RFWD3 0.82 11.38 0.57 1.07e-24 Testicular germ cell tumor; CESC cis rs208346 1.000 rs208346 chr7:2799686 G/T cg19717773 chr7:2847554 GNA12 0.5 7.99 0.44 4.21e-14 Loneliness (linear analysis); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09311052 chr1:154531418 UBE2Q1 0.48 6.67 0.38 1.51e-10 Systemic lupus erythematosus; CESC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg06494592 chr3:125709126 NA -0.51 -5.44 -0.32 1.22e-7 Blood pressure (smoking interaction); CESC cis rs9911578 0.902 rs12948746 chr17:57071892 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.09 -0.4 1.21e-11 Intelligence (multi-trait analysis); CESC cis rs2408955 0.542 rs7975632 chr12:48443048 C/T cg04545296 chr12:48745243 ZNF641 0.35 6.14 0.35 3.05e-9 Glycated hemoglobin levels; CESC cis rs11264213 0.901 rs72661640 chr1:36447232 T/G cg27506609 chr1:36549197 TEKT2 0.67 5.56 0.32 6.59e-8 Schizophrenia; CESC cis rs10256972 0.527 rs28671326 chr7:1174973 G/A cg16145915 chr7:1198662 ZFAND2A -0.63 -9.68 -0.51 3.64e-19 Longevity;Endometriosis; CESC cis rs35110281 0.641 rs9978858 chr21:45085552 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -8.79 -0.48 1.89e-16 Mean corpuscular volume; CESC trans rs11098499 0.821 rs10032151 chr4:120391628 C/T cg25214090 chr10:38739885 LOC399744 0.71 10.27 0.53 4.75e-21 Corneal astigmatism; CESC cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg17366294 chr4:99064904 C4orf37 0.56 7.52 0.42 8.37e-13 Colonoscopy-negative controls vs population controls; CESC cis rs17376456 0.825 rs56108532 chr5:93276342 C/T cg21475434 chr5:93447410 FAM172A 0.73 6.34 0.36 9.97e-10 Diabetic retinopathy; CESC cis rs965469 1.000 rs6037560 chr20:3323055 T/C cg25506879 chr20:3388711 C20orf194 -0.52 -5.66 -0.33 3.89e-8 IFN-related cytopenia; CESC cis rs1801251 0.778 rs2592115 chr2:233736349 C/T cg25237894 chr2:233734115 C2orf82 -0.48 -8.7 -0.47 3.54e-16 Coronary artery disease; CESC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.57 -0.37 2.69e-10 Depression; CESC cis rs7107174 0.688 rs11237489 chr11:78130325 G/A cg02023728 chr11:77925099 USP35 0.43 5.45 0.32 1.17e-7 Testicular germ cell tumor; CESC cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg25427524 chr10:38739819 LOC399744 -0.67 -9.8 -0.52 1.46e-19 Extrinsic epigenetic age acceleration; CESC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg12463550 chr7:65579703 CRCP -0.54 -6.96 -0.39 2.67e-11 Aortic root size; CESC cis rs9715521 0.719 rs11936702 chr4:59849081 G/A cg11281224 chr4:60001000 NA -0.5 -6.56 -0.37 2.88e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10129255 0.957 rs10137980 chr14:107183974 G/C cg07958169 chr14:107095056 NA -0.41 -5.72 -0.33 2.86e-8 Kawasaki disease; CESC cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg20503657 chr10:835505 NA 0.79 7.89 0.44 8.13e-14 Eosinophil percentage of granulocytes; CESC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg19774624 chr17:42201019 HDAC5 -0.69 -10.03 -0.52 2.7e-20 Total body bone mineral density; CESC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.73 0.55 1.55e-22 Height; CESC trans rs7618501 0.633 rs7628058 chr3:50039474 C/T cg21659725 chr3:3221576 CRBN 0.52 7.13 0.4 9.35e-12 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19882093 chr20:23969397 GGTLC1 -0.46 -6.58 -0.37 2.56e-10 Gut microbiome composition (summer); CESC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg03576123 chr11:487126 PTDSS2 -1.04 -10.83 -0.55 7.17e-23 Body mass index; CESC cis rs9815354 0.638 rs73073267 chr3:42021163 A/T cg03022575 chr3:42003672 ULK4 0.74 6.59 0.38 2.33e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg16325326 chr1:53192061 ZYG11B 0.83 14.09 0.65 4.81e-34 Monocyte count; CESC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg02574844 chr11:5959923 NA -0.42 -5.6 -0.33 5.48e-8 DNA methylation (variation); CESC cis rs9815354 0.812 rs59476821 chr3:41946481 A/G cg03022575 chr3:42003672 ULK4 0.71 6.45 0.37 5.42e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs1707322 0.964 rs785499 chr1:46592420 G/A cg05343316 chr1:45956843 TESK2 -0.47 -5.52 -0.32 7.97e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs524023 0.958 rs11231825 chr11:64360274 T/C cg07220939 chr11:64358617 SLC22A12 -0.36 -5.59 -0.32 5.57e-8 Urate levels in obese individuals; CESC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg02772935 chr3:125709198 NA -0.47 -5.14 -0.3 5.41e-7 Blood pressure (smoking interaction); CESC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs933688 0.532 rs868557 chr5:90550379 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.45 -5.03 -0.3 9.09e-7 Smoking behavior; CESC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg26335602 chr6:28129616 ZNF389 0.38 5.49 0.32 9.51e-8 Cardiac Troponin-T levels; CESC cis rs2294693 0.945 rs9394755 chr6:41006680 C/T cg14418226 chr6:40996092 UNC5CL -0.42 -5.28 -0.31 2.7e-7 Gastric cancer;Non-cardia gastric cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19487717 chr11:70263216 CTTN 0.46 6.19 0.36 2.25e-9 Fibrinogen levels; CESC cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.18 0.4 6.99e-12 Tonsillectomy; CESC cis rs4472734 0.896 rs3902966 chr1:214629277 C/T cg00063699 chr1:214624242 PTPN14 -0.33 -5.08 -0.3 7.25e-7 Height; CESC cis rs1538970 0.962 rs9429160 chr1:45827968 G/T cg06784218 chr1:46089804 CCDC17 0.32 5.16 0.3 4.76e-7 Platelet count; CESC trans rs561341 1.000 rs7214017 chr17:30332220 T/C cg20587970 chr11:113659929 NA -1.1 -13.84 -0.65 3.63e-33 Hip circumference adjusted for BMI; CESC cis rs9818758 0.607 rs61729488 chr3:49067904 T/C cg00383909 chr3:49044727 WDR6 0.87 5.62 0.33 4.88e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs1008375 0.898 rs9998130 chr4:17593905 A/G cg02297831 chr4:17616191 MED28 0.55 6.3 0.36 1.24e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg18876405 chr7:65276391 NA -0.59 -7.97 -0.44 4.6e-14 Aortic root size; CESC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg06456125 chr7:65229604 NA -0.4 -5.23 -0.31 3.44e-7 Aortic root size; CESC cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 10.2 0.53 7.77e-21 Platelet count; CESC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg14558114 chr2:88469736 THNSL2 -0.5 -7.28 -0.41 3.9e-12 Response to metformin (IC50); CESC cis rs7582720 0.943 rs72932583 chr2:203869847 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg14393609 chr7:65229607 NA 0.45 6.2 0.36 2.11e-9 Calcium levels; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg22645636 chr2:55496232 MTIF2 -0.42 -6.08 -0.35 4.09e-9 Vertical cup-disc ratio; CESC cis rs6426558 0.537 rs4653813 chr1:227461510 G/C cg10327440 chr1:227177885 CDC42BPA 0.49 6.09 0.35 4.02e-9 Neutrophil percentage of white cells; CESC cis rs9660992 0.710 rs1768586 chr1:205238275 A/G cg00857998 chr1:205179979 DSTYK 0.45 5.22 0.31 3.7e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.6 0.47 7.29e-16 Menopause (age at onset); CESC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.42 0.32 1.33e-7 Bipolar disorder; CESC cis rs59072704 0.843 rs12031783 chr1:244498748 A/G cg16908123 chr1:244486252 NA 0.44 6.82 0.39 6.1e-11 Monocyte count; CESC cis rs11098499 0.954 rs9685777 chr4:120365965 C/A cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs10779751 0.960 rs12739368 chr1:11288247 T/C cg08854313 chr1:11322531 MTOR 0.79 10.62 0.55 3.5e-22 Body mass index; CESC cis rs9611565 0.559 rs4822048 chr22:41988225 C/T cg03806693 chr22:41940476 POLR3H -1.16 -13.06 -0.63 1.99e-30 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11432751 chr19:40854313 C19orf47;PLD3 0.56 6.7 0.38 1.25e-10 Gut microbiome composition (summer); CESC cis rs7223966 1.000 rs9901112 chr17:61730617 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 6.8 0.39 6.72e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs3733585 0.699 rs12498956 chr4:9950705 G/T cg11266682 chr4:10021025 SLC2A9 -0.57 -11.03 -0.56 1.61e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs5750830 0.594 rs5757647 chr22:39775047 C/A cg02038168 chr22:39784481 NA -0.56 -7.35 -0.41 2.5e-12 Intelligence (multi-trait analysis); CESC cis rs9916302 0.904 rs9894500 chr17:37515735 G/C cg20243544 chr17:37824526 PNMT -0.47 -5.74 -0.33 2.54e-8 Glomerular filtration rate (creatinine); CESC cis rs9911578 1.000 rs302848 chr17:56686454 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.41 5.51 0.32 8.34e-8 Intelligence (multi-trait analysis); CESC cis rs17209837 0.607 rs2071645 chr7:87105276 G/C cg00919237 chr7:87102261 ABCB4 -0.48 -6.15 -0.35 2.77e-9 Gallbladder cancer; CESC cis rs9399135 0.838 rs4896126 chr6:135342786 C/A cg22676075 chr6:135203613 NA 0.51 7.36 0.41 2.34e-12 Red blood cell count; CESC cis rs901683 1.000 rs12764693 chr10:46023327 A/G cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20318713 chr1:45805724 MUTYH;TOE1 -0.46 -6.19 -0.36 2.3e-9 Fibrinogen levels; CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg09177884 chr7:1199841 ZFAND2A -0.64 -8.48 -0.46 1.59e-15 Longevity;Endometriosis; CESC cis rs2243480 0.908 rs4718273 chr7:65216099 G/A cg12463550 chr7:65579703 CRCP -0.69 -5.32 -0.31 2.22e-7 Diabetic kidney disease; CESC cis rs10857712 0.851 rs56153177 chr10:135216975 G/A cg01444801 chr10:135216882 MTG1 -0.49 -5.62 -0.33 4.92e-8 Systemic lupus erythematosus; CESC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg14926445 chr8:58193284 C8orf71 -0.47 -5.09 -0.3 6.82e-7 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg07092213 chr7:1199455 ZFAND2A -0.39 -5.3 -0.31 2.43e-7 Longevity;Endometriosis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25750404 chr12:6579648 VAMP1 -0.45 -6.46 -0.37 4.92e-10 Gambling; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg19319069 chr7:129593010 UBE2H -0.42 -6.58 -0.37 2.45e-10 Vertical cup-disc ratio; CESC cis rs1005277 0.522 rs1208767 chr10:38042295 G/T cg25517755 chr10:38738941 LOC399744 -0.4 -5.14 -0.3 5.37e-7 Extrinsic epigenetic age acceleration; CESC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.22 0.45 8.86e-15 Menopause (age at onset); CESC cis rs8067545 0.611 rs9907516 chr17:20070490 G/A cg13482628 chr17:19912719 NA 0.43 5.74 0.33 2.65e-8 Schizophrenia; CESC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg00310523 chr12:86230176 RASSF9 0.35 5.52 0.32 7.92e-8 Major depressive disorder; CESC cis rs3617 0.591 rs2276823 chr3:52869263 C/A cg11645453 chr3:52864694 ITIH4 -0.26 -5.21 -0.3 3.84e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs17641971 0.645 rs341806 chr8:50034028 A/C cg00325661 chr8:49890786 NA 0.39 5.28 0.31 2.64e-7 Blood metabolite levels; CESC cis rs2247341 0.928 rs2854916 chr4:1721348 G/A cg07465881 chr4:1713556 SLBP -0.51 -6.21 -0.36 2.01e-9 Hip circumference adjusted for BMI;Height; CESC cis rs2408955 0.522 rs11168408 chr12:48498327 G/A cg04545296 chr12:48745243 ZNF641 -0.37 -6.24 -0.36 1.77e-9 Glycated hemoglobin levels; CESC cis rs7264396 0.561 rs6058387 chr20:34568092 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -7.68 -0.43 3.12e-13 Total cholesterol levels; CESC cis rs4629710 0.592 rs11759793 chr6:131546384 G/A cg12606694 chr6:131520996 AKAP7 0.46 5.7 0.33 3.18e-8 Multiple myeloma (IgH translocation); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15680518 chr12:132414800 PUS1 0.48 6.2 0.36 2.12e-9 Gut microbiota (bacterial taxa); CESC cis rs4423214 1.000 rs12792306 chr11:71166992 T/C cg24826892 chr11:71159390 DHCR7 0.44 5.06 0.3 7.93e-7 Vitamin D levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25299201 chr13:22178312 EFHA1 0.55 6.54 0.37 3.08e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20110633 chr19:44302906 LYPD5 0.59 6.93 0.39 3.15e-11 Gut microbiome composition (summer); CESC cis rs12950390 0.853 rs4794107 chr17:45843159 T/G cg00777063 chr17:45855553 NA -0.41 -6.12 -0.35 3.4e-9 IgG glycosylation; CESC cis rs4919087 0.748 rs701817 chr10:98977329 G/C cg25902810 chr10:99078978 FRAT1 -0.49 -5.6 -0.33 5.38e-8 Monocyte count; CESC cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg26597838 chr10:835615 NA 0.86 9.03 0.49 3.59e-17 Eosinophil percentage of granulocytes; CESC cis rs3733585 0.699 rs11724510 chr4:9958583 C/T cg11266682 chr4:10021025 SLC2A9 -0.6 -11.22 -0.57 3.77e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1879734 0.636 rs2186041 chr1:54180287 G/A cg23596471 chr1:54105337 GLIS1 0.31 5.13 0.3 5.63e-7 Mitral valve prolapse; CESC cis rs9435341 0.965 rs1730864 chr1:107607810 C/T cg09367891 chr1:107599246 PRMT6 -0.71 -8.53 -0.46 1.13e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg24308560 chr3:49941425 MST1R -0.64 -9.19 -0.49 1.17e-17 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08386450 chr20:43104574 TTPAL 0.54 6.42 0.37 6.19e-10 Gut microbiome composition (summer); CESC trans rs1814175 0.645 rs2140602 chr11:50022800 G/C cg03929089 chr4:120376271 NA -0.91 -14.8 -0.67 1.58e-36 Height; CESC cis rs12348691 0.503 rs894672 chr9:100612185 C/T cg13688889 chr9:100608707 NA -0.9 -13.6 -0.64 2.68e-32 Alopecia areata; CESC cis rs2439831 0.717 rs28495368 chr15:43895642 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.82 8.62 0.47 6.24e-16 Lung cancer in ever smokers; CESC trans rs11088226 0.681 rs2409456 chr21:33929374 G/A cg09050820 chr6:167586206 TCP10L2 0.86 8.44 0.46 2.16e-15 Gastritis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26512142 chr11:2554198 KCNQ1 -0.42 -6.28 -0.36 1.35e-9 Gambling; CESC cis rs2742234 0.590 rs2505506 chr10:43645854 C/T cg15436174 chr10:43711423 RASGEF1A -0.47 -5.43 -0.32 1.29e-7 Hirschsprung disease; CESC trans rs6818288 0.778 rs4619851 chr4:30077626 T/C cg12528397 chr3:62933670 NA 0.42 6.13 0.35 3.2e-9 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03277652 chr8:142011117 PTK2 -0.48 -6.58 -0.37 2.46e-10 Fibrinogen levels; CESC trans rs1814175 0.653 rs10839480 chr11:50034556 C/T cg03929089 chr4:120376271 NA -0.94 -15.73 -0.69 7.69e-40 Height; CESC cis rs4919087 0.884 rs4917762 chr10:98976471 G/T cg25902810 chr10:99078978 FRAT1 0.71 10.11 0.53 1.53e-20 Monocyte count; CESC cis rs2070997 0.607 rs4740371 chr9:133673777 G/C cg11464064 chr9:133710261 ABL1 0.57 6.69 0.38 1.33e-10 Response to amphetamines; CESC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg06456125 chr7:65229604 NA -0.4 -5.15 -0.3 5.12e-7 Aortic root size; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15150274 chr8:33330294 FUT10 0.5 6.52 0.37 3.54e-10 Systemic lupus erythematosus; CESC cis rs1594829 0.535 rs17055121 chr8:26170975 C/T cg11498726 chr8:26250323 BNIP3L -0.41 -6.3 -0.36 1.23e-9 Height; CESC cis rs854765 0.647 rs854770 chr17:18019048 A/G cg04398451 chr17:18023971 MYO15A -0.78 -11.5 -0.58 4.15e-25 Total body bone mineral density; CESC cis rs9814567 0.752 rs1880378 chr3:134330709 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.09 -0.3 6.84e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs698813 0.763 rs698764 chr2:44573658 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.52 6.16 0.35 2.64e-9 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs10779751 0.770 rs2791643 chr1:11207269 C/T cg08854313 chr1:11322531 MTOR 0.74 9.41 0.5 2.46e-18 Body mass index; CESC cis rs668210 0.793 rs507672 chr11:65767153 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 -0.72 -7.94 -0.44 5.7e-14 Cerebrospinal fluid biomarker levels; CESC cis rs10411936 0.720 rs2885706 chr19:16582937 C/A cg10248733 chr19:16607483 C19orf44;CALR3 0.53 6.64 0.38 1.82e-10 White blood cell count;Multiple sclerosis; CESC cis rs941873 0.835 rs10762859 chr10:81103370 T/A cg08514558 chr10:81106712 PPIF 0.33 5.63 0.33 4.55e-8 Height; CESC cis rs7927592 0.956 rs12277225 chr11:68340967 T/C cg20283391 chr11:68216788 NA -0.49 -5.85 -0.34 1.43e-8 Total body bone mineral density; CESC cis rs2637266 1.000 rs7392737 chr10:78366059 C/T cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg11645453 chr3:52864694 ITIH4 -0.27 -5.17 -0.3 4.67e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs7772486 0.790 rs2265472 chr6:146220758 G/C cg23711669 chr6:146136114 FBXO30 0.92 13.36 0.63 1.78e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs2963155 0.518 rs33389 chr5:142700499 C/T cg17617527 chr5:142782415 NR3C1 0.81 7.53 0.42 8.03e-13 Breast cancer; CESC cis rs6460942 0.597 rs7808537 chr7:12520913 G/C cg10578991 chr7:12443926 VWDE -0.48 -5.06 -0.3 7.85e-7 Coronary artery disease; CESC cis rs9790314 0.846 rs6768818 chr3:160951648 A/G cg03342759 chr3:160939853 NMD3 -0.51 -7.37 -0.41 2.12e-12 Morning vs. evening chronotype; CESC cis rs1059312 0.500 rs10734964 chr12:129286486 C/T cg09035930 chr12:129282057 SLC15A4 0.53 6.8 0.39 6.98e-11 Systemic lupus erythematosus; CESC cis rs2486288 0.656 rs7166580 chr15:45571209 C/G cg09092052 chr15:45571596 NA 0.45 5.33 0.31 2.14e-7 Glomerular filtration rate; CESC cis rs2070997 0.607 rs2987902 chr9:133710246 A/T cg11464064 chr9:133710261 ABL1 0.73 8.42 0.46 2.44e-15 Response to amphetamines; CESC cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg03709012 chr19:19516395 GATAD2A 1.01 15.93 0.7 1.49e-40 Tonsillectomy; CESC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg11987759 chr7:65425863 GUSB -0.47 -6.32 -0.36 1.09e-9 Calcium levels; CESC cis rs72781680 0.948 rs113530757 chr2:24142500 G/A cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs80130819 0.748 rs2732474 chr12:48700817 A/T cg05342945 chr12:48394962 COL2A1 -0.51 -5.6 -0.33 5.35e-8 Prostate cancer; CESC cis rs7267979 0.966 rs2500417 chr20:25383287 A/G cg08601574 chr20:25228251 PYGB -0.36 -5.06 -0.3 7.97e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15227217 chr7:35734836 HERPUD2 0.56 6.71 0.38 1.14e-10 Gut microbiome composition (summer); CESC cis rs10751667 0.961 rs7395928 chr11:952605 T/G cg06064525 chr11:970664 AP2A2 -0.39 -6.99 -0.39 2.29e-11 Alzheimer's disease (late onset); CESC cis rs1153858 1.000 rs7169587 chr15:45640379 A/G cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg19318889 chr4:1322082 MAEA 0.37 5.04 0.3 8.49e-7 Longevity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17142486 chr19:56089493 ZNF579 0.45 6.0 0.35 6.49e-9 Fibrinogen levels; CESC cis rs4319547 0.915 rs10773208 chr12:122970156 T/C cg23029597 chr12:123009494 RSRC2 -0.5 -5.43 -0.32 1.26e-7 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27549887 chr15:48623952 DUT 0.61 7.22 0.41 5.58e-12 Gut microbiome composition (summer); CESC trans rs4843747 0.636 rs4075597 chr16:88107590 C/A cg26811252 chr16:29126840 RRN3P2 0.67 9.33 0.5 4.29e-18 Menopause (age at onset); CESC cis rs2228479 0.764 rs11641201 chr16:89983276 T/C cg04287289 chr16:89883240 FANCA 0.56 5.07 0.3 7.38e-7 Skin colour saturation; CESC cis rs13242816 1.000 rs17138750 chr7:116134170 A/G cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC cis rs17102884 0.506 rs4899541 chr14:75403437 T/G cg11812906 chr14:75593930 NEK9 -0.44 -5.41 -0.32 1.44e-7 Neuroticism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10729317 chr20:2821390 FAM113A;VPS16 -0.41 -6.0 -0.35 6.63e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs67366981 1.000 rs56357623 chr14:77697393 C/A cg22824376 chr14:77648248 TMEM63C 0.65 5.52 0.32 8.21e-8 Obsessive-compulsive symptoms; CESC cis rs6582630 0.555 rs10880625 chr12:38526612 A/C cg13010199 chr12:38710504 ALG10B 0.53 6.84 0.39 5.44e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs16867321 1.000 rs4289138 chr2:181364220 T/G cg23363182 chr2:181467187 NA -0.41 -5.13 -0.3 5.65e-7 Obesity; CESC cis rs8062405 0.755 rs4787456 chr16:28559573 C/T cg07382826 chr16:28625726 SULT1A1 0.4 6.69 0.38 1.3e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs8133932 0.654 rs2839041 chr21:47322616 T/C cg14185626 chr21:47401492 COL6A1 0.46 5.04 0.3 8.81e-7 Schizophrenia; CESC cis rs889312 0.500 rs252903 chr5:56117952 A/G cg14703610 chr5:56206110 C5orf35 0.47 6.28 0.36 1.35e-9 Breast cancer;Breast cancer (early onset); CESC cis rs7772486 0.686 rs2328708 chr6:146095739 G/A cg05347473 chr6:146136440 FBXO30 -0.5 -6.57 -0.37 2.59e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27442478 chr6:155635788 TFB1M 0.58 7.04 0.4 1.7e-11 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs11030122 0.673 rs10835596 chr11:4099666 C/T cg18678763 chr11:4115507 RRM1 -0.54 -7.1 -0.4 1.14e-11 Mean platelet volume;Platelet distribution width; CESC cis rs1878931 0.726 rs3843728 chr16:3448251 T/C cg00484396 chr16:3507460 NAT15 -0.41 -6.43 -0.37 5.87e-10 Body mass index (adult); CESC trans rs3942852 0.550 rs1113480 chr11:48058313 G/T cg15704280 chr7:45808275 SEPT13 -0.71 -9.0 -0.48 4.61e-17 Acute lymphoblastic leukemia (childhood); CESC cis rs412000 0.560 rs4793583 chr17:56451407 A/C cg25039879 chr17:56429692 SUPT4H1 -0.42 -5.56 -0.32 6.45e-8 Primary tooth development (time to first tooth eruption); CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg17372223 chr3:52568218 NT5DC2 0.43 7.02 0.4 1.87e-11 Bipolar disorder; CESC cis rs4148883 0.615 rs2187483 chr4:100134103 G/T cg12011299 chr4:100065546 ADH4 -0.5 -7.15 -0.4 8.48e-12 Alcohol dependence; CESC cis rs2120019 1.000 rs35577967 chr15:75354621 G/A cg09165964 chr15:75287851 SCAMP5 -0.73 -8.47 -0.46 1.7e-15 Blood trace element (Zn levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10971928 chr5:16902573 MYO10 -0.56 -6.77 -0.38 8.27e-11 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.83 0.39 5.96e-11 Bipolar disorder; CESC cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg23158103 chr7:148848205 ZNF398 -0.38 -5.97 -0.34 7.45e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs10851478 0.872 rs34694913 chr15:49831894 G/T cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC trans rs829883 0.902 rs829884 chr12:98879500 C/G cg04550079 chr16:67212681 KIAA0895L -0.37 -6.07 -0.35 4.34e-9 Colorectal adenoma (advanced); CESC cis rs35146811 0.586 rs12705067 chr7:99594726 T/C cg22531904 chr7:99595276 NA -0.39 -5.23 -0.31 3.39e-7 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08321272 chr4:41992621 SLC30A9 -0.45 -6.18 -0.35 2.45e-9 Gut microbiota (bacterial taxa); CESC cis rs9611565 0.592 rs4481089 chr22:41980892 T/C cg06634786 chr22:41940651 POLR3H -0.57 -6.28 -0.36 1.35e-9 Vitiligo; CESC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg05973401 chr12:123451056 ABCB9 0.62 8.09 0.44 2.23e-14 Platelet count; CESC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg24101359 chr6:42928495 GNMT 0.56 8.16 0.45 1.38e-14 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg17971929 chr21:40555470 PSMG1 -0.55 -7.22 -0.41 5.4e-12 Menarche (age at onset); CESC cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg18904891 chr8:8559673 CLDN23 0.73 8.12 0.45 1.74e-14 Obesity-related traits; CESC cis rs2839186 0.605 rs2839174 chr21:47676934 T/C cg00815214 chr21:47717953 NA -0.36 -5.3 -0.31 2.44e-7 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg03676636 chr4:99064102 C4orf37 0.34 5.19 0.3 4.17e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08984023 chr10:64133896 ZNF365 0.47 6.28 0.36 1.4e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24865802 chr22:42084920 NHP2L1 0.55 6.11 0.35 3.48e-9 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg07701084 chr6:150067640 NUP43 0.43 6.0 0.35 6.51e-9 Lung cancer; CESC cis rs7246657 0.525 rs10410594 chr19:37477758 C/T cg23950597 chr19:37808831 NA -0.51 -5.05 -0.3 8.18e-7 Coronary artery calcification; CESC cis rs4906332 0.966 rs2065016 chr14:103879656 T/A cg09975044 chr14:104007538 NA 0.46 6.34 0.36 9.68e-10 Coronary artery disease; CESC cis rs929354 0.772 rs2301914 chr7:157000176 T/C cg05182265 chr7:156933206 UBE3C -0.5 -7.41 -0.41 1.68e-12 Body mass index; CESC cis rs9457247 1.000 rs2769354 chr6:167379771 G/T cg25258033 chr6:167368657 RNASET2 -0.42 -6.25 -0.36 1.63e-9 Crohn's disease; CESC cis rs4642101 0.824 rs3889515 chr3:12844112 G/C cg05775895 chr3:12838266 CAND2 0.39 5.78 0.33 2.1e-8 QRS complex (12-leadsum); CESC trans rs11098499 0.865 rs1112817 chr4:120297800 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs11098499 0.505 rs75122014 chr4:120362426 G/C cg24375607 chr4:120327624 NA 0.47 5.9 0.34 1.11e-8 Corneal astigmatism; CESC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg25767906 chr1:53392781 SCP2 -0.51 -6.76 -0.38 8.8e-11 Monocyte count; CESC cis rs2933343 0.909 rs1683817 chr3:128651536 G/A cg25356066 chr3:128598488 ACAD9 0.63 7.53 0.42 8.01e-13 IgG glycosylation; CESC cis rs644799 1.000 rs12291986 chr11:95523030 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.31 0.5 5.15e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11122272 0.735 rs2572253 chr1:231512768 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.8 -0.43 1.41e-13 Hemoglobin concentration; CESC cis rs4843747 0.671 rs8053377 chr16:88106465 A/G cg17633681 chr16:88106987 BANP 0.76 10.43 0.54 1.41e-21 Menopause (age at onset); CESC cis rs8077577 0.895 rs10048161 chr17:18082796 C/G cg16794390 chr17:18148240 FLII 0.42 5.64 0.33 4.41e-8 Obesity-related traits; CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26546685 chr4:100870642 LOC256880;H2AFZ 0.51 5.22 0.31 3.55e-7 Gut microbiome composition (summer); CESC cis rs3820928 0.967 rs16822905 chr2:227770727 G/C cg05526886 chr2:227700861 RHBDD1 -0.41 -5.29 -0.31 2.59e-7 Pulmonary function; CESC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg18016565 chr1:150552671 MCL1 0.34 5.18 0.3 4.39e-7 Tonsillectomy; CESC cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC cis rs1691799 0.899 rs1168357 chr12:66749879 T/C cg16791601 chr12:66731901 HELB -0.79 -14.19 -0.66 2.26e-34 White blood cell count (basophil); CESC cis rs12681366 0.537 rs2381886 chr8:95477053 T/C cg13257157 chr8:95487014 RAD54B 0.45 5.47 0.32 1.05e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs1949733 0.656 rs2631762 chr4:8423122 A/T cg11789530 chr4:8429930 ACOX3 0.71 10.13 0.53 1.32e-20 Response to antineoplastic agents; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21774865 chr7:157009442 UBE3C 0.48 6.66 0.38 1.58e-10 Fibrinogen levels; CESC cis rs12579753 1.000 rs11115030 chr12:82203021 A/T cg24719984 chr12:82153464 PPFIA2 -0.36 -5.07 -0.3 7.59e-7 Resting heart rate; CESC cis rs2859741 0.647 rs548661 chr1:37479392 T/G cg09363841 chr1:37513479 NA -0.51 -6.98 -0.39 2.43e-11 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs501120 0.810 rs473501 chr10:44749171 G/A cg09554077 chr10:44749378 NA 0.52 6.93 0.39 3.28e-11 Coronary artery disease;Coronary heart disease; CESC cis rs6723226 0.739 rs2069213 chr2:32743084 C/T cg02381751 chr2:32503542 YIPF4 0.85 12.52 0.61 1.4e-28 Intelligence (multi-trait analysis); CESC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 5.76 0.33 2.31e-8 Bipolar disorder; CESC cis rs4150161 0.656 rs2288026 chr16:84220344 C/G cg10106505 chr16:84220380 TAF1C 0.77 5.56 0.32 6.75e-8 Systolic blood pressure response to hydrochlorothiazide in hypertension; CESC cis rs72901758 0.669 rs17641275 chr17:76247796 A/C cg26068271 chr17:76253126 NA -0.43 -6.48 -0.37 4.5e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg02574844 chr11:5959923 NA -0.5 -7.68 -0.43 3.13e-13 DNA methylation (variation); CESC cis rs763014 0.865 rs8909 chr16:633851 T/C cg00908189 chr16:619842 PIGQ 0.65 9.0 0.48 4.54e-17 Height; CESC cis rs4654899 0.758 rs12402486 chr1:21447935 A/G cg05370193 chr1:21551575 ECE1 -0.37 -5.58 -0.32 5.9e-8 Superior frontal gyrus grey matter volume; CESC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.82 10.65 0.55 2.75e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12128740 chr1:62207888 INADL 0.41 6.04 0.35 5.1e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25723933 chr1:155099956 EFNA1 0.57 6.17 0.35 2.52e-9 Gut microbiome composition (summer); CESC cis rs4319547 0.508 rs10846826 chr12:122894987 C/T cg05707623 chr12:122985044 ZCCHC8 -0.53 -6.11 -0.35 3.47e-9 Body mass index; CESC cis rs59918340 0.764 rs10101692 chr8:142230823 C/T cg16341495 chr8:142228727 SLC45A4 -0.44 -5.37 -0.31 1.72e-7 Immature fraction of reticulocytes; CESC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg11644478 chr21:40555479 PSMG1 1.06 17.91 0.74 1.44e-47 Cognitive function; CESC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.73 0.33 2.7e-8 Tonsillectomy; CESC cis rs61931739 0.817 rs304313 chr12:34216898 C/T cg19457237 chr12:34500585 NA -0.37 -5.1 -0.3 6.51e-7 Morning vs. evening chronotype; CESC cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.44 -0.32 1.19e-7 Huntington's disease progression; CESC cis rs9921222 0.500 rs8046256 chr16:393948 C/T cg00101154 chr16:420108 MRPL28 -0.55 -6.08 -0.35 4.17e-9 Bone mineral density (spine);Bone mineral density; CESC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.6 -8.3 -0.45 5.42e-15 Alzheimer's disease; CESC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg12516959 chr21:47718080 NA 0.34 5.1 0.3 6.55e-7 Testicular germ cell tumor; CESC cis rs7904368 0.806 rs3858182 chr10:16855094 C/T cg23933602 chr10:16859644 RSU1 0.76 7.09 0.4 1.19e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs6076065 0.748 rs4142246 chr20:23388975 A/G cg11657817 chr20:23433608 CST11 0.4 6.11 0.35 3.46e-9 Facial morphology (factor 15, philtrum width); CESC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg11890956 chr21:40555474 PSMG1 1.22 24.53 0.83 3.87e-70 Cognitive function; CESC cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg19748678 chr4:122722346 EXOSC9 0.79 10.06 0.53 2.23e-20 Type 2 diabetes; CESC cis rs751837 0.591 rs34407983 chr14:103429786 T/C cg18135206 chr14:102964638 TECPR2 0.69 5.07 0.3 7.46e-7 Large B-cell lymphoma; CESC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.43e-21 Prudent dietary pattern; CESC cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg05535760 chr7:792225 HEATR2 0.94 10.83 0.55 7.19e-23 Cerebrospinal P-tau181p levels; CESC cis rs6964587 0.967 rs410 chr7:91557425 C/G cg17063962 chr7:91808500 NA -0.59 -7.85 -0.43 1.03e-13 Breast cancer; CESC trans rs9944275 0.860 rs71396871 chr15:97192085 C/G cg26794346 chr6:16472305 ATXN1 0.75 6.06 0.35 4.65e-9 Depressive symptoms (multi-trait analysis);Neuroticism (multi-trait analysis); CESC cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg05295671 chr13:79234353 RNF219 0.36 5.1 0.3 6.4e-7 Large artery stroke; CESC cis rs13064411 0.696 rs9808893 chr3:113228444 G/A cg18753928 chr3:113234510 CCDC52 -0.5 -6.13 -0.35 3.23e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.46 -5.55 -0.32 7.03e-8 Tuberculosis; CESC cis rs3806843 0.568 rs2530232 chr5:140082878 A/G cg26395211 chr5:140044315 WDR55 0.47 5.97 0.34 7.78e-9 Depressive symptoms (multi-trait analysis); CESC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg26338869 chr17:61819248 STRADA 0.69 9.21 0.49 1.06e-17 Prudent dietary pattern; CESC cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7173419 0.655 rs12899295 chr15:28226597 G/A cg20906524 chr15:28200668 OCA2 -0.38 -5.21 -0.31 3.72e-7 Eye color; CESC cis rs1878931 0.582 rs27227 chr16:3429778 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.66 -8.0 -0.44 3.94e-14 Body mass index (adult); CESC trans rs4689592 0.546 rs10937782 chr4:7057106 G/C cg07817883 chr1:32538562 TMEM39B -0.52 -6.14 -0.35 2.95e-9 Monocyte percentage of white cells; CESC cis rs2304069 0.545 rs13168011 chr5:149392377 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.48 6.51 0.37 3.82e-10 HIV-1 control; CESC cis rs11764590 0.694 rs3996323 chr7:2079428 G/T cg21782813 chr7:2030301 MAD1L1 -0.41 -5.36 -0.31 1.8e-7 Neuroticism; CESC trans rs916888 0.773 rs199439 chr17:44793503 A/G cg22433210 chr17:43662623 NA 1.0 11.42 0.57 7.92e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1878931 0.582 rs9921152 chr16:3421199 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.71 8.83 0.48 1.51e-16 Body mass index (adult); CESC cis rs1065852 0.861 rs5758627 chr22:42572547 C/T cg00645731 chr22:42541494 CYP2D7P1 0.6 9.14 0.49 1.73e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg25934064 chr3:52569026 NT5DC2 0.26 5.61 0.33 5e-8 Bipolar disorder; CESC cis rs4268898 0.662 rs2288074 chr2:24413595 C/T cg20701182 chr2:24300061 SF3B14 0.69 6.97 0.39 2.47e-11 Asthma; CESC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg20887711 chr4:1340912 KIAA1530 0.85 11.46 0.58 5.8e-25 Longevity; CESC cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg02297831 chr4:17616191 MED28 0.55 6.83 0.39 5.64e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.7 0.43 2.77e-13 Prudent dietary pattern; CESC cis rs2439831 1.000 rs527921 chr15:43770416 G/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.83 -12.08 -0.6 4.75e-27 Lung cancer in ever smokers; CESC cis rs9399135 0.967 rs12661423 chr6:135349570 C/T cg22676075 chr6:135203613 NA 0.48 6.66 0.38 1.62e-10 Red blood cell count; CESC cis rs9916302 0.706 rs2302073 chr17:37457342 A/G cg07936489 chr17:37558343 FBXL20 0.92 10.37 0.54 2.23e-21 Glomerular filtration rate (creatinine); CESC trans rs2727020 0.595 rs10839281 chr11:49483373 A/C cg03929089 chr4:120376271 NA -0.85 -13.36 -0.63 1.85e-31 Coronary artery disease; CESC cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg00290607 chr11:67383545 NA -0.38 -5.25 -0.31 3.15e-7 Mean corpuscular volume; CESC cis rs3806843 0.766 rs2530239 chr5:140062547 C/T cg26395211 chr5:140044315 WDR55 0.44 5.8 0.34 1.85e-8 Depressive symptoms (multi-trait analysis); CESC cis rs1976403 0.659 rs10799700 chr1:21820968 G/C cg02390115 chr1:21767211 NBPF3 0.4 5.72 0.33 2.92e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs61931739 0.500 rs1601628 chr12:34047375 A/C cg26384229 chr12:38710491 ALG10B 0.53 7.22 0.41 5.44e-12 Morning vs. evening chronotype; CESC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.0 0.39 2.11e-11 Height; CESC cis rs4481887 1.000 rs6681423 chr1:248482834 C/A cg00666640 chr1:248458726 OR2T12 0.41 6.64 0.38 1.75e-10 Common traits (Other); CESC cis rs9796 0.717 rs2947494 chr15:41375741 C/T cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.28 -0.36 1.39e-9 Menopause (age at onset); CESC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg04234412 chr22:24373322 LOC391322 0.46 6.48 0.37 4.57e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg00908189 chr16:619842 PIGQ 0.64 8.88 0.48 1.02e-16 Height; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg17944940 chr17:73285520 SLC25A19 0.5 6.16 0.35 2.65e-9 Bronchopulmonary dysplasia; CESC cis rs763121 0.853 rs2267394 chr22:39101633 T/C cg06022373 chr22:39101656 GTPBP1 0.94 17.57 0.73 2.32e-46 Menopause (age at onset); CESC cis rs9908102 0.740 rs59287437 chr17:12912727 C/G cg26162695 chr17:12921313 ELAC2 0.52 5.71 0.33 3.04e-8 Schizophrenia; CESC cis rs1712517 0.525 rs7911488 chr10:105154089 A/G cg04362960 chr10:104952993 NT5C2 -0.49 -5.94 -0.34 8.9e-9 Migraine; CESC cis rs9303401 0.703 rs8077052 chr17:57208921 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.68 8.89 0.48 9.48e-17 Cognitive test performance; CESC cis rs3820928 0.874 rs4675131 chr2:227836742 T/G cg11843606 chr2:227700838 RHBDD1 -0.51 -6.65 -0.38 1.64e-10 Pulmonary function; CESC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg16325326 chr1:53192061 ZYG11B -0.89 -15.22 -0.68 5.28e-38 Monocyte count; CESC cis rs4704187 0.687 rs7735937 chr5:74441700 G/A cg03227963 chr5:74354835 NA 0.3 5.54 0.32 7.14e-8 Response to amphetamines; CESC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.59 -0.58 2.1e-25 Type 2 diabetes; CESC cis rs3820928 0.874 rs4675132 chr2:227841792 A/C cg05526886 chr2:227700861 RHBDD1 -0.42 -5.26 -0.31 3.02e-7 Pulmonary function; CESC cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg04455712 chr21:45112962 RRP1B 0.48 7.68 0.43 3.17e-13 Mean corpuscular volume; CESC cis rs116095464 0.558 rs6555052 chr5:224268 G/A cg22857025 chr5:266934 NA -1.27 -18.88 -0.76 5.63e-51 Breast cancer; CESC cis rs4595586 0.525 rs3914597 chr12:39388693 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.6 0.42 4.97e-13 Morning vs. evening chronotype; CESC cis rs684232 0.602 rs445268 chr17:563338 G/A cg12384639 chr17:618140 VPS53 0.42 5.4 0.32 1.46e-7 Prostate cancer; CESC cis rs2243480 1.000 rs34702770 chr7:65344823 T/C cg18252515 chr7:66147081 NA -1.07 -10.29 -0.53 4.14e-21 Diabetic kidney disease; CESC cis rs34172651 0.917 rs2112786 chr16:24778944 C/T cg06028605 chr16:24865363 SLC5A11 0.35 5.5 0.32 8.72e-8 Intelligence (multi-trait analysis); CESC cis rs4969178 0.895 rs2292640 chr17:76396610 G/A cg20026190 chr17:76395443 PGS1 0.49 7.81 0.43 1.34e-13 HDL cholesterol levels; CESC cis rs13082711 0.911 rs2131205 chr3:27428501 A/G cg02860705 chr3:27208620 NA 0.52 6.71 0.38 1.14e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs1011108 1.000 rs1011108 chr2:26782621 A/G cg27305303 chr2:26781231 OTOF 0.27 5.28 0.31 2.74e-7 Periodontal microbiota; CESC cis rs10089 1.000 rs1864922 chr5:127420700 T/C cg19767477 chr5:127420684 SLC12A2 -0.41 -5.52 -0.32 7.88e-8 Ileal carcinoids; CESC cis rs7927592 0.956 rs7116899 chr11:68385535 G/T cg16797656 chr11:68205561 LRP5 0.38 5.28 0.31 2.69e-7 Total body bone mineral density; CESC cis rs1545257 0.537 rs3108793 chr2:24648138 A/C cg06627628 chr2:24431161 ITSN2 -0.49 -5.97 -0.34 7.67e-9 Sjögren's syndrome; CESC cis rs67311347 0.713 rs114569261 chr3:40314580 G/A cg09455208 chr3:40491958 NA 0.42 7.05 0.4 1.56e-11 Renal cell carcinoma; CESC cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3749237 0.595 rs6784820 chr3:49450864 C/T cg07636037 chr3:49044803 WDR6 -0.61 -9.07 -0.49 2.74e-17 Resting heart rate; CESC cis rs12681366 0.511 rs2919670 chr8:95456618 A/G cg13257157 chr8:95487014 RAD54B 0.45 5.47 0.32 1.05e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg25036284 chr2:26402008 FAM59B -0.67 -7.18 -0.4 6.93e-12 Gut microbiome composition (summer); CESC cis rs2635047 0.601 rs2635052 chr18:44650607 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.32 0.31 2.19e-7 Educational attainment; CESC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg25934064 chr3:52569026 NT5DC2 0.29 5.9 0.34 1.11e-8 Electroencephalogram traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17319894 chr3:9791448 OGG1 -0.46 -6.04 -0.35 5.25e-9 Fibrinogen levels; CESC cis rs4268898 0.662 rs72795832 chr2:24441855 C/A cg08917208 chr2:24149416 ATAD2B 0.51 5.14 0.3 5.36e-7 Asthma; CESC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg21770322 chr7:97807741 LMTK2 0.54 8.13 0.45 1.67e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs116095464 0.558 rs10077076 chr5:231940 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.57 -0.47 8.98e-16 Breast cancer; CESC cis rs4925386 1.000 rs4925382 chr20:60918542 G/C cg24112000 chr20:60950667 NA 0.51 7.53 0.42 8.17e-13 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs7584330 0.554 rs114331205 chr2:238432559 A/C cg14458575 chr2:238380390 NA 0.48 5.3 0.31 2.4e-7 Prostate cancer; CESC cis rs7772486 0.790 rs2249386 chr6:146186611 G/A cg23711669 chr6:146136114 FBXO30 1.02 15.79 0.7 4.7e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.93 0.52 5.92e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6032067 0.925 rs35875037 chr20:43859921 A/G cg10761708 chr20:43804764 PI3 0.52 6.29 0.36 1.34e-9 Blood protein levels; CESC cis rs6582630 0.502 rs11520278 chr12:38359642 T/A cg13010199 chr12:38710504 ALG10B 0.53 6.62 0.38 2.03e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg04025307 chr7:1156635 C7orf50 0.46 6.3 0.36 1.22e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3768617 0.510 rs10752899 chr1:183081241 T/G ch.1.3577855R chr1:183094577 LAMC1 0.88 14.13 0.66 3.71e-34 Fuchs's corneal dystrophy; CESC cis rs6460942 1.000 rs6460936 chr7:12404913 T/C cg02935154 chr7:12443704 VWDE -0.57 -5.8 -0.34 1.89e-8 Coronary artery disease; CESC cis rs12474201 0.925 rs17822294 chr2:46960004 G/A cg06386533 chr2:46925753 SOCS5 0.91 12.78 0.62 1.83e-29 Height; CESC cis rs116095464 0.558 rs61689490 chr5:224904 T/C cg10591111 chr5:226296 SDHA -0.52 -6.52 -0.37 3.47e-10 Breast cancer; CESC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg00769240 chr8:12517080 NA -0.44 -6.02 -0.35 5.7e-9 Blood pressure (smoking interaction); CESC cis rs26868 0.766 rs26867 chr16:2249410 T/C cg07587117 chr16:2239488 CASKIN1 0.33 5.34 0.31 2.02e-7 Height; CESC cis rs60843830 1.000 rs55936726 chr2:258210 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.89 12.07 0.6 5.23e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9318086 0.648 rs7330140 chr13:24473074 A/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.44 6.27 0.36 1.44e-9 Myopia (pathological); CESC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg17221315 chr6:27791827 HIST1H4J -0.42 -5.04 -0.3 8.78e-7 Parkinson's disease; CESC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg14703610 chr5:56206110 C5orf35 0.52 6.76 0.38 8.99e-11 Coronary artery disease; CESC cis rs2228479 0.850 rs11649162 chr16:89807131 C/A cg04013166 chr16:89971882 TCF25 0.76 6.59 0.38 2.39e-10 Skin colour saturation; CESC cis rs5769765 0.542 rs738707 chr22:50250827 G/A cg02269571 chr22:50332266 NA 0.46 5.44 0.32 1.19e-7 Schizophrenia; CESC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg22823121 chr1:150693482 HORMAD1 0.36 5.12 0.3 5.88e-7 Melanoma; CESC cis rs727505 1.000 rs68007199 chr7:124491307 T/C cg23710748 chr7:124431027 NA -0.48 -7.61 -0.42 4.76e-13 Lewy body disease; CESC cis rs1348850 0.914 rs12616443 chr2:178315751 A/G cg23306229 chr2:178417860 TTC30B 0.62 7.92 0.44 6.66e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7659604 0.540 rs10007956 chr4:122700669 A/T cg19748678 chr4:122722346 EXOSC9 -0.4 -5.1 -0.3 6.62e-7 Type 2 diabetes; CESC cis rs10791097 0.694 rs10894275 chr11:130756251 C/T cg12179176 chr11:130786555 SNX19 0.66 10.36 0.54 2.45e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg05863683 chr7:1912471 MAD1L1 0.36 5.31 0.31 2.32e-7 Bipolar disorder and schizophrenia; CESC cis rs1728785 1.000 rs7196104 chr16:68579746 C/A cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs2463822 0.669 rs72919484 chr11:62043430 T/C cg06239285 chr11:62104954 ASRGL1 -1.13 -9.21 -0.49 1.05e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs75477785 1.000 rs77249837 chr1:209988527 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs9302635 0.513 rs13334151 chr16:72189727 A/C cg01557791 chr16:72042693 DHODH -0.62 -6.91 -0.39 3.5e-11 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09546895 chr5:32174322 GOLPH3 -0.42 -6.13 -0.35 3.12e-9 Fibrinogen levels; CESC cis rs708547 0.647 rs781666 chr4:57830981 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.6 7.92 0.44 6.59e-14 Response to bleomycin (chromatid breaks); CESC cis rs6964587 1.000 rs10234071 chr7:91645152 C/G cg01689657 chr7:91764605 CYP51A1 -0.28 -5.09 -0.3 6.82e-7 Breast cancer; CESC trans rs747782 0.585 rs1316604 chr11:48279796 G/A cg15704280 chr7:45808275 SEPT13 0.68 6.39 0.37 7.34e-10 Intraocular pressure; CESC cis rs72781680 0.898 rs6545127 chr2:24060670 C/T cg20701182 chr2:24300061 SF3B14 0.62 5.6 0.33 5.24e-8 Lymphocyte counts; CESC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.17 -0.3 4.72e-7 Obesity-related traits; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.14 0.4 8.95e-12 Bipolar disorder; CESC cis rs11148252 0.904 rs7321964 chr13:53040822 A/G cg00495681 chr13:53174319 NA 0.38 5.29 0.31 2.52e-7 Lewy body disease; CESC cis rs2354432 0.607 rs7523812 chr1:146673489 A/G cg25205988 chr1:146714368 CHD1L -1.19 -9.08 -0.49 2.58e-17 Mitochondrial DNA levels; CESC cis rs2204008 0.502 rs2387275 chr12:38142836 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.5 0.54 8.8e-22 Bladder cancer; CESC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg08736216 chr1:53307985 ZYG11A -0.45 -7.38 -0.41 2e-12 Monocyte count; CESC cis rs1448094 0.872 rs10863146 chr12:86408326 C/G cg02569458 chr12:86230093 RASSF9 0.34 5.14 0.3 5.45e-7 Major depressive disorder; CESC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg11764359 chr7:65958608 NA -0.94 -15.34 -0.69 1.97e-38 Aortic root size; CESC cis rs2637266 1.000 rs12251543 chr10:78345465 G/A cg18941641 chr10:78392320 NA 0.43 7.93 0.44 5.97e-14 Pulmonary function; CESC cis rs3796619 1.000 rs28620427 chr4:1086247 T/G cg27284194 chr4:1044797 NA 0.37 5.69 0.33 3.38e-8 Recombination rate (males); CESC cis rs1322639 0.618 rs9505942 chr6:169591793 T/C cg03254818 chr6:169586852 NA 0.53 5.94 0.34 9.04e-9 Pulse pressure; CESC cis rs763121 0.925 rs9611008 chr22:39098787 T/C cg06022373 chr22:39101656 GTPBP1 0.88 15.22 0.68 5.14e-38 Menopause (age at onset); CESC cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg25554036 chr4:6271136 WFS1 0.48 7.6 0.42 5.21e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7927771 1.000 rs11039390 chr11:47796295 C/G cg20307385 chr11:47447363 PSMC3 -0.51 -6.25 -0.36 1.62e-9 Subjective well-being; CESC cis rs1348850 0.837 rs12619074 chr2:178472336 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 7.13 0.4 9.5e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2243480 1.000 rs160642 chr7:65558373 C/T cg18252515 chr7:66147081 NA -1.39 -13.81 -0.65 4.83e-33 Diabetic kidney disease; CESC cis rs34779708 0.897 rs12764820 chr10:35386321 G/A cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs7618501 1.000 rs4855862 chr3:49748833 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.44 -0.46 2.11e-15 Intelligence (multi-trait analysis); CESC cis rs7312933 0.533 rs11181499 chr12:42818761 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.45 0.37 5.42e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs9612 1.000 rs16976747 chr19:44238152 G/A cg08581076 chr19:44259116 C19orf61 0.56 6.37 0.36 8.53e-10 Exhaled nitric oxide output; CESC cis rs2932538 0.922 rs7522110 chr1:113072914 A/C cg22162597 chr1:113214053 CAPZA1 0.52 6.55 0.37 2.96e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -5.16 -0.3 4.75e-7 Personality dimensions; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06535952 chr19:56126775 NA 0.45 6.4 0.37 7.02e-10 Fibrinogen levels; CESC cis rs8114671 0.562 rs6088622 chr20:33419977 C/A cg08999081 chr20:33150536 PIGU 0.39 5.52 0.32 7.98e-8 Height; CESC cis rs4919044 0.545 rs9420603 chr10:94777490 T/C cg16508068 chr10:94451736 HHEX -0.5 -5.49 -0.32 9.61e-8 Coronary artery disease; CESC cis rs9611519 0.964 rs2092563 chr22:41592677 G/A cg03806693 chr22:41940476 POLR3H -0.58 -5.86 -0.34 1.39e-8 Neuroticism; CESC cis rs752010 0.631 rs7515066 chr1:42076915 A/G cg06885757 chr1:42089581 HIVEP3 -0.7 -11.66 -0.58 1.25e-25 Lupus nephritis in systemic lupus erythematosus; CESC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg13114125 chr14:105738426 BRF1 -0.86 -10.28 -0.53 4.36e-21 Mean platelet volume;Platelet distribution width; CESC cis rs6867032 1.000 rs2129472 chr5:2016247 G/A cg26168224 chr5:2018326 NA 0.96 19.64 0.77 1.3e-53 Gut microbiome composition (winter); CESC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg11764359 chr7:65958608 NA -0.77 -10.8 -0.55 8.76e-23 Aortic root size; CESC cis rs6570726 0.935 rs414646 chr6:145831685 T/C cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs16906415 0.546 rs71530187 chr8:137802025 C/T cg18579875 chr2:217540128 IGFBP5 -0.68 -6.01 -0.35 6.22e-9 IgG glycosylation; CESC cis rs9926296 0.681 rs12923946 chr16:89821080 C/T cg27121462 chr16:89883253 FANCA 0.57 6.9 0.39 3.71e-11 Vitiligo; CESC cis rs6141600 0.760 rs2590986 chr20:34686496 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -5.44 -0.32 1.2e-7 Height;Hip circumference; CESC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg26354017 chr1:205819088 PM20D1 0.4 5.31 0.31 2.28e-7 Prostate-specific antigen levels; CESC cis rs11792861 0.591 rs7027874 chr9:111717112 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.62 9.52 0.5 1.17e-18 Menarche (age at onset); CESC cis rs2370759 0.898 rs113412621 chr10:32579306 C/T cg05361325 chr10:32636312 EPC1 -0.55 -5.18 -0.3 4.39e-7 Sexual dysfunction (female); CESC cis rs8020095 0.571 rs7145917 chr14:67372526 C/T cg19548862 chr14:67692701 FAM71D -0.49 -6.03 -0.35 5.38e-9 Depression (quantitative trait); CESC cis rs2997447 0.761 rs56078964 chr1:26442600 C/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.17 0.3 4.68e-7 QRS complex (12-leadsum); CESC cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg17143192 chr8:8559678 CLDN23 0.69 8.55 0.46 1.02e-15 Obesity-related traits; CESC cis rs938554 0.513 rs3733588 chr4:9997303 A/G cg00071950 chr4:10020882 SLC2A9 -0.6 -7.86 -0.43 9.72e-14 Blood metabolite levels; CESC cis rs3733585 0.577 rs5014939 chr4:9953253 T/A cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1062177 0.855 rs6884630 chr5:151268997 A/T cg00977110 chr5:151150581 G3BP1 0.52 5.69 0.33 3.28e-8 Preschool internalizing problems; CESC cis rs10752881 1.000 rs10797810 chr1:182980950 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Colorectal cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02457826 chr20:30310733 BCL2L1 -0.49 -6.28 -0.36 1.39e-9 Fibrinogen levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20250396 chr14:65880036 FUT8;LOC645431 -0.44 -6.1 -0.35 3.75e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1707322 0.964 rs10437063 chr1:46273666 G/A cg05343316 chr1:45956843 TESK2 0.44 5.53 0.32 7.85e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11122272 0.735 rs2739507 chr1:231527329 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -7.18 -0.4 7.02e-12 Hemoglobin concentration; CESC cis rs921968 0.541 rs3821031 chr2:219295249 C/T cg02176678 chr2:219576539 TTLL4 -0.47 -8.27 -0.45 6.59e-15 Mean corpuscular hemoglobin concentration; CESC trans rs3780486 0.846 rs10124479 chr9:33136233 T/G cg20290983 chr6:43655470 MRPS18A 0.98 18.17 0.74 1.8e-48 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27277367 chr15:100106179 MEF2A 0.54 6.0 0.35 6.55e-9 Gut microbiome composition (summer); CESC cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg21573476 chr21:45109991 RRP1B -0.48 -6.69 -0.38 1.33e-10 Mean corpuscular volume; CESC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9303280 0.901 rs883770 chr17:38063381 C/T cg20243544 chr17:37824526 PNMT 0.56 7.37 0.41 2.23e-12 Self-reported allergy; CESC cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg02297831 chr4:17616191 MED28 0.49 5.83 0.34 1.61e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1775715 0.651 rs2808033 chr10:32194127 A/T cg18675610 chr10:32216311 ARHGAP12 0.34 5.24 0.31 3.21e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9487051 0.768 rs1766814 chr6:109526696 G/A cg01475377 chr6:109611718 NA -0.44 -6.67 -0.38 1.49e-10 Reticulocyte fraction of red cells; CESC cis rs6582630 0.598 rs10880645 chr12:38556172 G/A cg26384229 chr12:38710491 ALG10B -0.42 -5.5 -0.32 8.81e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs1045714 0.836 rs73033691 chr7:2636522 T/G cg20813462 chr7:2646259 IQCE 0.67 5.8 0.34 1.92e-8 Urate levels in lean individuals; CESC cis rs854765 0.663 rs1108648 chr17:17750558 G/A cg09796270 chr17:17721594 SREBF1 -0.44 -6.22 -0.36 1.97e-9 Total body bone mineral density; CESC trans rs2733310 0.793 rs28468978 chr15:57153089 C/A cg13494055 chr3:59115467 NA -0.43 -6.01 -0.35 6.06e-9 Mean platelet volume; CESC trans rs7230711 0.808 rs73960393 chr18:48755075 C/A cg03986574 chr11:64544080 SF1 -0.78 -6.3 -0.36 1.23e-9 Immune response to anthrax vaccine; CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg26335602 chr6:28129616 ZNF389 0.54 7.21 0.4 5.86e-12 Depression; CESC cis rs72781680 0.612 rs33913065 chr2:24344060 T/G cg06627628 chr2:24431161 ITSN2 -0.67 -6.56 -0.37 2.87e-10 Lymphocyte counts; CESC cis rs1215050 0.755 rs9991112 chr4:98651479 A/C cg05340658 chr4:99064831 C4orf37 -0.48 -6.22 -0.36 1.89e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg12310025 chr6:25882481 NA -0.63 -9.31 -0.5 5.2e-18 Intelligence (multi-trait analysis); CESC cis rs11785400 0.793 rs4467920 chr8:143736846 C/T cg10596483 chr8:143751796 JRK 0.43 5.41 0.32 1.37e-7 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03321319 chr22:22222323 MAPK1 -0.44 -6.82 -0.39 6.27e-11 Gambling; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg23597562 chr20:54976805 CSTF1 0.46 6.75 0.38 9.27e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg08704250 chr15:31115839 NA -0.63 -8.12 -0.45 1.82e-14 Huntington's disease progression; CESC cis rs35146811 0.883 rs4134903 chr7:99711040 G/A cg13334819 chr7:99746414 C7orf59 -0.44 -5.28 -0.31 2.65e-7 Coronary artery disease; CESC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4319547 0.695 rs10744211 chr12:122931820 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -5.77 -0.33 2.19e-8 Body mass index; CESC cis rs11252926 0.931 rs4881399 chr10:567325 A/G cg16386425 chr10:429943 DIP2C -0.46 -5.3 -0.31 2.42e-7 Psychosis in Alzheimer's disease; CESC trans rs1545843 0.595 rs11116360 chr12:84791082 A/G cg03015433 chr16:56623111 MT3 -0.33 -6.01 -0.35 6.11e-9 Major depressive disorder; CESC cis rs9818758 0.607 rs13087930 chr3:48961726 A/G cg00383909 chr3:49044727 WDR6 0.95 6.8 0.39 6.82e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs6424115 0.692 rs573361 chr1:24053674 A/T cg15997130 chr1:24165203 NA 0.42 5.62 0.33 4.95e-8 Immature fraction of reticulocytes; CESC cis rs10979 1.000 rs12203151 chr6:143884856 C/T cg25407410 chr6:143891975 LOC285740 -0.63 -9.57 -0.51 8.08e-19 Hypospadias; CESC cis rs228437 0.913 rs7763821 chr6:134939618 A/G cg24504307 chr6:134963096 NA -0.47 -5.52 -0.32 8.01e-8 Melanoma; CESC cis rs7927771 0.524 rs10838740 chr11:47679980 A/G cg20307385 chr11:47447363 PSMC3 0.6 8.38 0.46 3.1e-15 Subjective well-being; CESC cis rs2717559 0.542 rs2585156 chr8:143879795 G/A cg17252645 chr8:143867129 LY6D -0.33 -5.75 -0.33 2.43e-8 Urinary tract infection frequency; CESC trans rs7246760 1.000 rs10412903 chr19:9880927 C/A cg02900749 chr2:68251473 NA -0.71 -6.55 -0.37 3.05e-10 Pursuit maintenance gain; CESC cis rs4268898 0.662 rs72795832 chr2:24441855 C/A cg06627628 chr2:24431161 ITSN2 -0.98 -11.22 -0.57 3.77e-24 Asthma; CESC cis rs8067354 0.645 rs7215180 chr17:57822354 A/G cg13753209 chr17:57696993 CLTC 0.65 7.89 0.44 7.95e-14 Hemoglobin concentration; CESC cis rs13315871 0.929 rs13094898 chr3:58290143 G/A cg20936604 chr3:58311152 NA -0.63 -5.04 -0.3 8.69e-7 Cholesterol, total; CESC cis rs4604732 0.631 rs4436425 chr1:247632323 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.5 6.39 0.37 7.55e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs113835537 0.529 rs11227509 chr11:66281194 T/C cg22134325 chr11:66188745 NPAS4 0.37 5.81 0.34 1.77e-8 Airway imaging phenotypes; CESC cis rs6964587 1.000 rs9969198 chr7:91567492 G/T cg17063962 chr7:91808500 NA -0.58 -7.81 -0.43 1.34e-13 Breast cancer; CESC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg09781414 chr16:715207 WDR90 -0.35 -5.33 -0.31 2.07e-7 Height; CESC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg08736216 chr1:53307985 ZYG11A -0.37 -6.43 -0.37 6.03e-10 Monocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04526616 chr7:4757846 FOXK1 0.46 6.32 0.36 1.13e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01919652 chr6:150259930 NA 0.54 6.1 0.35 3.65e-9 Gut microbiome composition (summer); CESC cis rs910316 0.737 rs175045 chr14:75475275 A/C cg08847533 chr14:75593920 NEK9 -0.86 -13.32 -0.63 2.49e-31 Height; CESC cis rs11098499 0.909 rs11098530 chr4:120413154 C/T cg09307838 chr4:120376055 NA 0.92 12.96 0.62 4.27e-30 Corneal astigmatism; CESC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs4141404 0.828 rs2413043 chr22:31648576 G/T cg13145458 chr22:31556086 RNF185 0.46 5.26 0.31 2.98e-7 Paclitaxel-induced neuropathy; CESC cis rs12887734 0.524 rs17791722 chr14:104286210 C/T cg08213375 chr14:104286397 PPP1R13B 0.4 6.86 0.39 4.74e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs3126085 0.597 rs12047544 chr1:152169922 C/T cg26876637 chr1:152193138 HRNR 0.44 5.04 0.3 8.68e-7 Atopic dermatitis; CESC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg21951975 chr1:209979733 IRF6 0.62 9.5 0.5 1.3e-18 Cleft lip with or without cleft palate; CESC cis rs7917772 0.502 rs2296583 chr10:104244322 T/G ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.25 0.31 3.06e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs208520 0.802 rs1342959 chr6:66883329 A/G cg07460842 chr6:66804631 NA -0.94 -12.15 -0.6 2.75e-27 Exhaled nitric oxide output; CESC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 10.92 0.56 3.59e-23 Platelet count; CESC trans rs1116547 0.571 rs11748794 chr5:112917278 T/G cg10115368 chr14:100435663 NA 0.5 6.01 0.35 6.13e-9 Cerebral amyloid angiopathy; CESC cis rs3820928 0.874 rs9288618 chr2:227872617 A/G cg11843606 chr2:227700838 RHBDD1 -0.46 -6.03 -0.35 5.41e-9 Pulmonary function; CESC cis rs1003719 0.646 rs2032063 chr21:38576657 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.58e-15 Eye color traits; CESC cis rs10876993 0.890 rs7963927 chr12:58046272 T/G cg18357645 chr12:58087776 OS9 0.59 9.07 0.49 2.72e-17 Celiac disease or Rheumatoid arthritis; CESC cis rs72781680 0.898 rs56303870 chr2:24086944 G/A cg08917208 chr2:24149416 ATAD2B 0.91 8.38 0.46 3.04e-15 Lymphocyte counts; CESC cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg11502198 chr6:26597334 ABT1 0.52 5.34 0.31 1.99e-7 Intelligence (multi-trait analysis); CESC cis rs7165102 1.000 rs600193 chr15:65729409 A/G cg11441148 chr15:65824328 PTPLAD1 -0.32 -5.33 -0.31 2.1e-7 Mean corpuscular hemoglobin; CESC cis rs9814567 1.000 rs9968172 chr3:134231251 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.44 5.97 0.34 7.69e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs208520 1.000 rs208536 chr6:66963440 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -9.42 -0.5 2.36e-18 Exhaled nitric oxide output; CESC cis rs11048434 0.736 rs1805733 chr12:9089272 A/C cg23795048 chr12:9217529 LOC144571 0.33 5.12 0.3 5.94e-7 Sjögren's syndrome; CESC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg14393609 chr7:65229607 NA 0.47 6.24 0.36 1.68e-9 Calcium levels; CESC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.36 0.31 1.83e-7 Bipolar disorder; CESC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.21 0.3 3.86e-7 Menopause (age at onset); CESC trans rs7726839 0.540 rs72703078 chr5:594987 A/C cg25482853 chr8:67687455 SGK3 1.04 10.11 0.53 1.55e-20 Obesity-related traits; CESC cis rs12220238 0.915 rs11001027 chr10:76152655 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.55 5.1 0.3 6.42e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs6674176 0.660 rs3791112 chr1:44379248 T/G cg23954153 chr1:44402353 ARTN -0.35 -5.47 -0.32 1.04e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20044189 chr5:141704548 SPRY4 -0.49 -6.29 -0.36 1.33e-9 Ulcerative colitis; CESC cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg04315214 chr1:2043799 PRKCZ -0.4 -6.51 -0.37 3.71e-10 Height; CESC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg22535103 chr8:58192502 C8orf71 -0.96 -9.81 -0.52 1.45e-19 Developmental language disorder (linguistic errors); CESC cis rs2832077 0.527 rs2705690 chr21:30239245 T/A cg24692254 chr21:30365293 RNF160 0.53 6.89 0.39 3.98e-11 Cognitive test performance; CESC cis rs7851660 0.901 rs7873389 chr9:100609230 C/T cg13688889 chr9:100608707 NA -0.69 -10.57 -0.54 4.92e-22 Strep throat; CESC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg24549020 chr5:56110836 MAP3K1 -0.49 -6.0 -0.35 6.46e-9 Initial pursuit acceleration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14354430 chr9:136911493 BRD3 0.45 6.02 0.35 5.86e-9 Fibrinogen levels; CESC cis rs7223966 1.000 rs9908044 chr17:61747032 A/C cg11494091 chr17:61959527 GH2 0.38 5.35 0.31 1.93e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2439831 1.000 rs689647 chr15:43762196 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.17 0.6 2.26e-27 Lung cancer in ever smokers; CESC cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg10523679 chr1:76189770 ACADM 0.72 8.42 0.46 2.33e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7107174 1.000 rs10793297 chr11:78009660 T/C cg02023728 chr11:77925099 USP35 0.5 6.66 0.38 1.62e-10 Testicular germ cell tumor; CESC cis rs10751667 0.714 rs7396700 chr11:963863 A/C cg20946044 chr11:1010712 AP2A2 -0.38 -5.35 -0.31 1.92e-7 Alzheimer's disease (late onset); CESC cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg11941060 chr3:133502564 NA -0.45 -6.09 -0.35 4.01e-9 Iron status biomarkers; CESC cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs7223966 1.000 rs9901507 chr17:61765524 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.44 0.42 1.42e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4481887 0.708 rs6587463 chr1:248544452 G/C cg26353448 chr1:248524236 OR2T4 -0.37 -5.12 -0.3 5.85e-7 Common traits (Other); CESC cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg23711669 chr6:146136114 FBXO30 1.01 15.9 0.7 1.9e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs1799949 0.965 rs4793234 chr17:41436183 A/G cg25072359 chr17:41440525 NA 0.44 5.9 0.34 1.13e-8 Menopause (age at onset); CESC cis rs11158198 0.738 rs10134110 chr14:58573183 C/G cg15908186 chr14:58618357 C14orf37 0.34 5.17 0.3 4.64e-7 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs7914558 0.933 rs10786729 chr10:104719378 A/G cg04362960 chr10:104952993 NT5C2 0.43 5.51 0.32 8.58e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6987853 0.933 rs55881007 chr8:42367290 A/G cg09913449 chr8:42400586 C8orf40 -0.42 -6.72 -0.38 1.1e-10 Mean corpuscular hemoglobin concentration; CESC cis rs17253792 0.915 rs74580958 chr14:56181511 G/A cg01858014 chr14:56050164 KTN1 -0.94 -7.27 -0.41 4.03e-12 Putamen volume; CESC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg22920501 chr2:26401640 FAM59B -0.65 -7.61 -0.42 4.88e-13 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg24562669 chr7:97807699 LMTK2 0.52 7.59 0.42 5.59e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg24881330 chr22:46731750 TRMU 0.77 6.19 0.36 2.26e-9 LDL cholesterol;Cholesterol, total; CESC cis rs3741151 0.686 rs17851510 chr11:73106294 A/C cg17517138 chr11:73019481 ARHGEF17 0.82 6.55 0.37 3.06e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.78 -0.33 2.05e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6750795 0.746 rs1667301 chr2:232423717 C/T cg12810212 chr2:232379626 C2orf52 0.38 5.14 0.3 5.36e-7 Height; CESC cis rs4595586 0.655 rs11170269 chr12:39387077 G/A cg26384229 chr12:38710491 ALG10B 0.44 6.31 0.36 1.15e-9 Morning vs. evening chronotype; CESC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg06808227 chr14:105710500 BRF1 -0.6 -6.87 -0.39 4.44e-11 Mean platelet volume;Platelet distribution width; CESC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg06873352 chr17:61820015 STRADA 0.73 12.89 0.62 7.87e-30 Prudent dietary pattern; CESC cis rs2559856 1.000 rs2559858 chr12:102089300 A/G cg12213457 chr12:102090980 CHPT1 -0.37 -5.56 -0.32 6.66e-8 Blood protein levels; CESC cis rs6456156 0.792 rs10946214 chr6:167516122 G/A cg23791538 chr6:167370224 RNASET2 -0.4 -5.21 -0.3 3.82e-7 Primary biliary cholangitis; CESC cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.17 0.3 4.59e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.28 0.6 9.45e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9291683 0.620 rs4383618 chr4:10125151 T/C cg00071950 chr4:10020882 SLC2A9 -0.56 -8.61 -0.47 6.51e-16 Bone mineral density; CESC cis rs73206853 0.841 rs56379265 chr12:110956370 G/A cg12870014 chr12:110450643 ANKRD13A 0.63 5.22 0.31 3.56e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs11098499 0.909 rs28581362 chr4:120283548 T/A cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs1395 0.778 rs2078616 chr2:27441904 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.45 5.99 0.35 6.99e-9 Blood metabolite levels; CESC cis rs6831352 0.918 rs17217949 chr4:100054312 A/G cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs7178572 0.568 rs1125617 chr15:77532711 A/G cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC cis rs14403 0.874 rs3006923 chr1:243648757 C/G cg21452805 chr1:244014465 NA -0.47 -5.65 -0.33 4.05e-8 Schizophrenia; CESC cis rs36051895 0.623 rs7847811 chr9:5237081 T/C cg02405213 chr9:5042618 JAK2 -0.56 -6.62 -0.38 1.95e-10 Pediatric autoimmune diseases; CESC cis rs6570726 0.905 rs452770 chr6:145847162 T/C cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 2e-26 Lobe attachment (rater-scored or self-reported); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg06348651 chr12:110562118 IFT81 -0.46 -6.28 -0.36 1.36e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg18252515 chr7:66147081 NA -0.44 -5.96 -0.34 8.18e-9 Aortic root size; CESC cis rs10899021 1.000 rs61900635 chr11:74359010 C/G cg25880958 chr11:74394337 NA -0.76 -7.25 -0.41 4.55e-12 Response to metformin (IC50); CESC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg24531977 chr5:56204891 C5orf35 0.69 9.31 0.5 5.13e-18 Initial pursuit acceleration; CESC cis rs6582630 0.537 rs7299661 chr12:38527713 C/T cg26384229 chr12:38710491 ALG10B 0.66 10.09 0.53 1.76e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs11690935 0.918 rs12692978 chr2:172725981 C/T cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.0 -0.65 1.06e-33 Schizophrenia; CESC cis rs854765 0.583 rs7207395 chr17:17819335 C/T cg09796270 chr17:17721594 SREBF1 0.47 6.52 0.37 3.49e-10 Total body bone mineral density; CESC cis rs2629540 0.765 rs7097254 chr10:126512248 A/C cg08799069 chr10:126477246 METTL10 -0.54 -7.95 -0.44 5.38e-14 Cocaine dependence; CESC cis rs16917546 1.000 rs10995249 chr10:64396916 C/T cg03961010 chr10:64397487 ZNF365 -0.37 -6.06 -0.35 4.7e-9 Basal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17554553 chr10:31321002 ZNF438 0.55 6.24 0.36 1.75e-9 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg08888203 chr3:10149979 C3orf24 0.45 5.57 0.32 6.17e-8 Alzheimer's disease; CESC trans rs875971 1.000 rs2042133 chr7:65931922 A/G cg26939375 chr7:64535504 NA 0.47 6.09 0.35 4.06e-9 Aortic root size; CESC cis rs9303401 0.659 rs7216648 chr17:56790858 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC cis rs752010 0.875 rs11210501 chr1:42091634 T/C cg06885757 chr1:42089581 HIVEP3 0.46 7.42 0.41 1.64e-12 Lupus nephritis in systemic lupus erythematosus; CESC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg00750074 chr16:89608354 SPG7 -0.37 -5.33 -0.31 2.13e-7 Multiple myeloma (IgH translocation); CESC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg26354017 chr1:205819088 PM20D1 0.84 12.49 0.61 1.86e-28 Menarche (age at onset); CESC cis rs1538970 0.884 rs61788261 chr1:45899114 G/A cg24296786 chr1:45957014 TESK2 -0.46 -5.28 -0.31 2.72e-7 Platelet count; CESC cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg26408565 chr15:76604113 ETFA -0.43 -6.25 -0.36 1.65e-9 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11563264 chr4:190862026 FRG1 0.53 6.02 0.35 5.71e-9 Gut microbiome composition (summer); CESC cis rs1865760 0.532 rs2794719 chr6:26088890 T/G cg17691542 chr6:26056736 HIST1H1C 0.45 6.0 0.35 6.36e-9 Height; CESC cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg02297831 chr4:17616191 MED28 0.61 7.82 0.43 1.23e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg06221963 chr1:154839813 KCNN3 -0.68 -11.89 -0.59 2.11e-26 Prostate cancer; CESC cis rs11098499 0.866 rs12374352 chr4:120281977 C/T cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs17209837 1.000 rs45554032 chr7:87078547 G/T cg00919237 chr7:87102261 ABCB4 -0.5 -5.85 -0.34 1.44e-8 Gallbladder cancer; CESC cis rs2070997 0.607 rs2480372 chr9:133706389 G/A cg11464064 chr9:133710261 ABL1 0.68 7.89 0.44 8.03e-14 Response to amphetamines; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg14064766 chr2:239344455 ASB1 0.5 6.32 0.36 1.11e-9 Recombination measurement; CESC cis rs7017914 0.783 rs13252584 chr8:71689031 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg24881330 chr22:46731750 TRMU -0.87 -9.79 -0.52 1.6e-19 LDL cholesterol;Cholesterol, total; CESC cis rs1707322 0.963 rs34907901 chr1:46405214 T/G cg03146154 chr1:46216737 IPP 0.72 9.69 0.51 3.34e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7772486 0.875 rs854146 chr6:146341033 A/G cg05347473 chr6:146136440 FBXO30 0.51 6.56 0.37 2.88e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs752010 0.967 rs10890151 chr1:42101843 C/A cg06885757 chr1:42089581 HIVEP3 0.49 7.83 0.43 1.17e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.1 -12.68 -0.61 4e-29 Gut microbiome composition (summer); CESC trans rs2727020 0.658 rs10839278 chr11:49450847 G/C cg15704280 chr7:45808275 SEPT13 -0.91 -15.67 -0.69 1.28e-39 Coronary artery disease; CESC trans rs72996113 0.702 rs79174253 chr11:100519054 A/C cg20136100 chr11:63974860 FERMT3 -0.51 -6.49 -0.37 4.27e-10 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs2354432 0.607 rs1890039 chr1:146681951 T/C cg25205988 chr1:146714368 CHD1L 1.15 8.65 0.47 4.98e-16 Mitochondrial DNA levels; CESC cis rs6912958 0.559 rs183599 chr6:88061024 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.45 8.02 0.44 3.47e-14 Monocyte percentage of white cells; CESC cis rs3796352 1.000 rs13078971 chr3:53103645 G/C cg15956490 chr3:53032818 SFMBT1 0.63 5.18 0.3 4.44e-7 Immune reponse to smallpox (secreted IL-2); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19006130 chr11:118478252 PHLDB1 -0.47 -6.53 -0.37 3.36e-10 Fibrinogen levels; CESC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg24060327 chr5:131705240 SLC22A5 -0.77 -10.83 -0.55 7.15e-23 Breast cancer; CESC cis rs6582630 0.502 rs11610978 chr12:38356957 C/G cg26384229 chr12:38710491 ALG10B 0.67 9.99 0.52 3.88e-20 Drug-induced liver injury (flucloxacillin); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25061763 chr12:62860430 MON2 0.45 6.02 0.35 5.95e-9 Gut microbiota (bacterial taxa); CESC cis rs782590 0.935 rs782606 chr2:55886602 T/C cg18811423 chr2:55921094 PNPT1 0.79 12.72 0.62 3.03e-29 Metabolic syndrome; CESC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.16 0.3 4.85e-7 Personality dimensions; CESC cis rs4589502 1.000 rs79390908 chr15:67130924 C/T cg12317470 chr15:67143691 NA 0.68 5.26 0.31 2.92e-7 Lung cancer (smoking interaction); CESC cis rs1707322 0.717 rs3014245 chr1:46086913 C/T cg06784218 chr1:46089804 CCDC17 -0.42 -7.24 -0.41 4.76e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4588572 0.644 rs2241566 chr5:77784738 C/T cg11547950 chr5:77652471 NA 0.39 5.38 0.31 1.61e-7 Triglycerides; CESC cis rs7666738 0.645 rs10013290 chr4:99082799 G/A cg05340658 chr4:99064831 C4orf37 0.75 10.74 0.55 1.38e-22 Colonoscopy-negative controls vs population controls; CESC cis rs6964587 0.967 rs28594877 chr7:91644070 C/T cg17063962 chr7:91808500 NA 0.55 7.63 0.42 4.25e-13 Breast cancer; CESC cis rs4919694 0.572 rs12261294 chr10:104934952 C/T cg04362960 chr10:104952993 NT5C2 0.64 6.44 0.37 5.66e-10 Arsenic metabolism; CESC cis rs67478160 0.571 rs1155751 chr14:104286547 C/G cg01849466 chr14:104193079 ZFYVE21 -0.49 -6.96 -0.39 2.65e-11 Schizophrenia; CESC cis rs9457247 1.000 rs422094 chr6:167397033 C/G cg23791538 chr6:167370224 RNASET2 -0.6 -8.48 -0.46 1.57e-15 Crohn's disease; CESC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg04944784 chr2:26401820 FAM59B -0.78 -8.86 -0.48 1.18e-16 Gut microbiome composition (summer); CESC cis rs9549367 0.826 rs9549710 chr13:113898064 A/C cg18105134 chr13:113819100 PROZ -0.68 -8.11 -0.45 1.94e-14 Platelet distribution width; CESC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg11965913 chr1:205819406 PM20D1 -0.46 -6.4 -0.37 6.88e-10 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs2251381 0.520 rs873651 chr21:30781848 G/A cg24692254 chr21:30365293 RNF160 0.47 6.03 0.35 5.46e-9 Selective IgA deficiency; CESC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg09177884 chr7:1199841 ZFAND2A -0.49 -6.42 -0.37 6.31e-10 Longevity;Endometriosis; CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg11803278 chr7:157951799 PTPRN2 0.28 5.96 0.34 7.98e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs7824557 0.591 rs2043510 chr8:11225168 G/A cg21775007 chr8:11205619 TDH -0.55 -8.56 -0.47 9.45e-16 Retinal vascular caliber; CESC cis rs34734847 1.000 rs55730005 chr12:121157536 C/A cg21892295 chr12:121157589 UNC119B -0.42 -6.65 -0.38 1.66e-10 Mean corpuscular volume; CESC cis rs4642101 0.793 rs6799179 chr3:12829095 A/C cg24848339 chr3:12840334 CAND2 0.36 5.48 0.32 9.72e-8 QRS complex (12-leadsum); CESC cis rs8114671 0.562 rs2076667 chr20:33506964 G/A cg06115741 chr20:33292138 TP53INP2 0.48 5.79 0.34 1.97e-8 Height; CESC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg16325326 chr1:53192061 ZYG11B 0.75 11.27 0.57 2.57e-24 Monocyte count; CESC cis rs709400 0.628 rs72708854 chr14:103864885 T/C cg12935359 chr14:103987150 CKB -0.53 -7.76 -0.43 1.88e-13 Body mass index; CESC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.09 -0.35 3.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2239547 0.521 rs9682464 chr3:52888485 C/T cg11645453 chr3:52864694 ITIH4 0.32 5.91 0.34 1.04e-8 Schizophrenia; CESC cis rs68170813 0.559 rs17428126 chr7:106897037 C/T cg02696742 chr7:106810147 HBP1 -0.52 -5.08 -0.3 7.2e-7 Coronary artery disease; CESC cis rs34779708 0.931 rs4007289 chr10:35269790 G/A cg03585969 chr10:35415529 CREM 0.76 10.14 0.53 1.27e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7937682 0.710 rs674230 chr11:111437887 A/G cg22437258 chr11:111473054 SIK2 0.74 9.62 0.51 5.34e-19 Primary sclerosing cholangitis; CESC cis rs72781680 0.898 rs56315094 chr2:23941952 T/C cg08917208 chr2:24149416 ATAD2B 1.0 9.21 0.49 1.03e-17 Lymphocyte counts; CESC cis rs9906944 0.707 rs9916472 chr17:47109998 C/T cg09029085 chr17:47094198 IGF2BP1 0.26 5.07 0.3 7.32e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs11122272 0.735 rs2250704 chr1:231486647 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.24 0.36 1.69e-9 Hemoglobin concentration; CESC cis rs2398668 0.570 rs4721548 chr7:2330496 A/G cg08027265 chr7:2291960 NA -0.44 -7.28 -0.41 3.83e-12 Bipolar disorder and schizophrenia; CESC cis rs7267979 1.000 rs11100 chr20:25281184 G/C cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7551222 0.716 rs12041075 chr1:204492153 C/G cg20240347 chr1:204465584 NA -0.28 -5.69 -0.33 3.39e-8 Schizophrenia; CESC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -5.69 -0.33 3.45e-8 Tonsillectomy; CESC trans rs57221529 0.766 rs12521051 chr5:560440 A/G cg25482853 chr8:67687455 SGK3 -1.07 -12.11 -0.6 3.81e-27 Lung disease severity in cystic fibrosis; CESC cis rs4234284 0.556 rs34147515 chr3:126965137 G/C cg27326032 chr3:127006922 NA -0.4 -5.5 -0.32 8.97e-8 Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel); CESC cis rs116095464 0.558 rs61492827 chr5:225774 A/G cg10591111 chr5:226296 SDHA -0.52 -6.52 -0.37 3.47e-10 Breast cancer; CESC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg07677032 chr17:61819896 STRADA 0.42 5.36 0.31 1.78e-7 Height; CESC cis rs2074585 0.560 rs12903058 chr15:91061121 G/T cg10434728 chr15:90938212 IQGAP1 -0.32 -5.35 -0.31 1.94e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg03538708 chr1:25844672 NA 0.38 5.8 0.34 1.92e-8 Erythrocyte sedimentation rate; CESC cis rs523522 0.962 rs687873 chr12:121019634 G/A cg27279351 chr12:120934652 DYNLL1 0.7 9.06 0.49 2.86e-17 High light scatter reticulocyte count; CESC cis rs7666738 0.649 rs28865589 chr4:98954279 C/A cg17366294 chr4:99064904 C4orf37 0.59 8.21 0.45 1.01e-14 Colonoscopy-negative controls vs population controls; CESC cis rs2732480 0.557 rs923397 chr12:48720392 G/A cg24011408 chr12:48396354 COL2A1 0.4 5.76 0.33 2.31e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6696846 0.749 rs11578293 chr1:205070178 T/C cg00857998 chr1:205179979 DSTYK 0.51 6.96 0.39 2.65e-11 Red blood cell count; CESC cis rs2204008 0.807 rs8186948 chr12:38325101 C/G cg26384229 chr12:38710491 ALG10B 0.69 10.31 0.53 3.6e-21 Bladder cancer; CESC cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg22903471 chr2:27725779 GCKR -0.53 -7.32 -0.41 2.91e-12 Total body bone mineral density; CESC cis rs7465272 0.500 rs7463655 chr8:143731034 G/C cg24634471 chr8:143751801 JRK 0.45 5.78 0.33 2.12e-8 Bipolar disorder and schizophrenia; CESC cis rs2760061 0.784 rs708116 chr1:228198196 C/A cg02753203 chr1:228287806 NA 0.53 7.89 0.44 8.14e-14 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15606388 chr17:42219409 C17orf53 0.57 6.22 0.36 1.93e-9 Gut microbiome composition (summer); CESC cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg00255919 chr5:131827918 IRF1 0.61 11.15 0.56 6.42e-24 Asthma (sex interaction); CESC cis rs4253772 0.515 rs9615968 chr22:46772695 A/G cg18190219 chr22:46762943 CELSR1 -0.77 -6.28 -0.36 1.34e-9 LDL cholesterol;Cholesterol, total; CESC cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg03709012 chr19:19516395 GATAD2A 0.99 15.45 0.69 7.62e-39 Tonsillectomy; CESC cis rs4919044 0.756 rs835257 chr10:94779801 T/A cg16508068 chr10:94451736 HHEX -0.5 -5.49 -0.32 9.61e-8 Coronary artery disease; CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg24642844 chr7:1081250 C7orf50 -0.64 -8.58 -0.47 8.21e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2070488 0.662 rs7372545 chr3:38507570 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.68 8.94 0.48 7.02e-17 Electrocardiographic conduction measures; CESC cis rs11711311 0.955 rs7650764 chr3:113414439 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 6.84 0.39 5.58e-11 IgG glycosylation; CESC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24568194 chr20:36156405 BLCAP -0.56 -6.43 -0.37 6.04e-10 Gut microbiome composition (summer); CESC cis rs72627123 0.867 rs59675549 chr14:74469480 A/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.8 5.77 0.33 2.2e-8 Morning vs. evening chronotype; CESC cis rs12042938 1.000 rs11122319 chr1:231808282 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.37 -5.16 -0.3 4.84e-7 Neuranatomic and neurocognitive phenotypes; CESC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.63 -0.38 1.85e-10 Bipolar disorder; CESC trans rs7395662 0.517 rs2021248 chr11:49013054 C/T cg00717180 chr2:96193071 NA -0.48 -6.59 -0.38 2.41e-10 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16098923 chr2:88927231 EIF2AK3 0.64 7.58 0.42 5.97e-13 Gut microbiome composition (summer); CESC cis rs4253772 0.530 rs9615362 chr22:46795141 A/C cg09491104 chr22:46646882 C22orf40 0.48 6.48 0.37 4.45e-10 LDL cholesterol;Cholesterol, total; CESC cis rs9549260 0.753 rs9532578 chr13:41236407 G/A cg21288729 chr13:41239152 FOXO1 0.54 5.12 0.3 5.76e-7 Red blood cell count; CESC cis rs7089973 0.604 rs7897937 chr10:116591318 A/G cg03647239 chr10:116582469 FAM160B1 0.43 5.29 0.31 2.6e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15262992 chr20:61442882 OGFR 0.44 6.11 0.35 3.54e-9 Fibrinogen levels; CESC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg17971929 chr21:40555470 PSMG1 1.05 16.66 0.72 4.09e-43 Cognitive function; CESC trans rs11098499 0.663 rs28369503 chr4:120238925 G/A cg25214090 chr10:38739885 LOC399744 0.59 8.11 0.45 1.85e-14 Corneal astigmatism; CESC cis rs1801251 0.896 rs2305141 chr2:233684402 A/G cg25237894 chr2:233734115 C2orf82 -0.36 -6.41 -0.37 6.47e-10 Coronary artery disease; CESC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 6.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11583043 1.000 rs17123612 chr1:101476814 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.53 5.84 0.34 1.54e-8 Ulcerative colitis;Inflammatory bowel disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01993411 chr20:44562842 PCIF1 0.54 6.74 0.38 1e-10 Gut microbiota (bacterial taxa); CESC cis rs7274811 0.688 rs56234419 chr20:32086447 C/T cg21523528 chr20:32077966 CBFA2T2 0.63 7.16 0.4 8.07e-12 Height; CESC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg18876405 chr7:65276391 NA 0.5 6.66 0.38 1.61e-10 Aortic root size; CESC cis rs7560272 0.501 rs12615807 chr2:73947583 T/C cg20560298 chr2:73613845 ALMS1 0.41 5.64 0.33 4.42e-8 Schizophrenia; CESC cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg22823121 chr1:150693482 HORMAD1 -0.41 -6.45 -0.37 5.32e-10 Tonsillectomy; CESC trans rs1973993 0.689 rs67544133 chr1:96971241 G/A cg10631902 chr5:14652156 NA -0.46 -6.25 -0.36 1.6e-9 Weight; CESC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg18876405 chr7:65276391 NA -0.49 -6.75 -0.38 9.38e-11 Aortic root size; CESC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.56 7.4 0.41 1.77e-12 Menopause (age at onset); CESC cis rs4253772 0.513 rs9615345 chr22:46713631 C/T cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.63 6.51 0.37 3.85e-10 LDL cholesterol;Cholesterol, total; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21786873 chr4:4250096 TMEM128 -0.5 -7.17 -0.4 7.36e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2732480 0.538 rs1387260 chr12:48703091 A/C cg04545296 chr12:48745243 ZNF641 0.43 7.15 0.4 8.3e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9457247 0.765 rs1322077 chr6:167424293 T/C cg23791538 chr6:167370224 RNASET2 -0.53 -7.37 -0.41 2.17e-12 Crohn's disease; CESC cis rs12449000 1 rs12449000 chr16:89872970 T/C cg04287289 chr16:89883240 FANCA 0.8 12.6 0.61 7.71e-29 Schizophrenia; CESC trans rs11098499 0.754 rs938056 chr4:120237453 C/T cg25214090 chr10:38739885 LOC399744 0.63 8.77 0.47 2.16e-16 Corneal astigmatism; CESC trans rs1038903 0.893 rs981103 chr4:28760835 A/G cg15651925 chr7:156259219 NA 0.49 6.11 0.35 3.59e-9 Menarche (age at onset); CESC cis rs4835473 0.932 rs9685306 chr4:144669996 G/A cg25736465 chr4:144833511 NA -0.43 -6.65 -0.38 1.67e-10 Immature fraction of reticulocytes; CESC cis rs8014204 0.967 rs4903266 chr14:75344941 C/G cg08847533 chr14:75593920 NEK9 -0.42 -5.1 -0.3 6.46e-7 Caffeine consumption; CESC cis rs10489525 0.599 rs11102879 chr1:115603504 C/T cg01522456 chr1:115632236 TSPAN2 0.48 5.67 0.33 3.69e-8 Autism; CESC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg03351412 chr1:154909251 PMVK 0.59 7.56 0.42 6.42e-13 Prostate cancer; CESC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg23803603 chr1:2058230 PRKCZ -0.34 -5.8 -0.34 1.92e-8 Height; CESC cis rs6570726 0.837 rs636894 chr6:145864122 T/C cg23711669 chr6:146136114 FBXO30 0.79 11.47 0.58 5.24e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg11890956 chr21:40555474 PSMG1 1.1 17.2 0.73 4.66e-45 Cognitive function; CESC cis rs818427 0.593 rs67293732 chr5:112217964 G/C cg07820702 chr5:112228657 REEP5 -0.4 -5.12 -0.3 5.75e-7 Total body bone mineral density; CESC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg21747405 chr11:67723411 NA -0.44 -6.69 -0.38 1.3100000000000001e-10 Blood pressure (smoking interaction); CESC cis rs9303280 0.806 rs12232497 chr17:38040119 T/C cg19468946 chr17:37922297 IKZF3 -0.41 -5.49 -0.32 9.59e-8 Self-reported allergy; CESC cis rs933688 1.000 rs10045280 chr5:90717675 T/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 12.36 0.6 5.13e-28 Smoking behavior; CESC trans rs2018683 0.707 rs1021689 chr7:28974223 G/T cg19402173 chr7:128379420 CALU -0.5 -6.62 -0.38 1.93e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs1065852 0.906 rs9611734 chr22:42502070 A/G cg00645731 chr22:42541494 CYP2D7P1 0.59 9.07 0.49 2.68e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.83 13.61 0.64 2.31e-32 Menarche (age at onset); CESC trans rs561341 1.000 rs530715 chr17:30320544 T/G cg20587970 chr11:113659929 NA -1.11 -14.12 -0.66 4e-34 Hip circumference adjusted for BMI; CESC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg24154853 chr7:158122151 PTPRN2 0.43 6.78 0.38 7.65e-11 Calcium levels; CESC trans rs1373453 0.908 rs17106937 chr12:70066280 A/G cg19702771 chr4:82058885 PRKG2 0.74 6.04 0.35 5.28e-9 Orofacial clefts; CESC cis rs4727027 0.901 rs1534197 chr7:148771970 T/C cg23158103 chr7:148848205 ZNF398 -0.41 -6.47 -0.37 4.66e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7833790 0.777 rs1005850 chr8:82692255 G/A cg17211192 chr8:82754475 SNX16 -0.69 -8.57 -0.47 8.92e-16 Diastolic blood pressure; CESC cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg14784868 chr12:69753453 YEATS4 0.83 12.94 0.62 5.03e-30 Blood protein levels; CESC cis rs17376456 1.000 rs10514382 chr5:93566534 G/A cg25358565 chr5:93447407 FAM172A 1.22 10.21 0.53 7.61e-21 Diabetic retinopathy; CESC cis rs6500602 0.627 rs860891 chr16:4586529 C/T cg08645402 chr16:4508243 NA -0.37 -5.76 -0.33 2.31e-8 Schizophrenia; CESC cis rs11690935 0.877 rs72890834 chr2:172835802 G/T cg13550731 chr2:172543902 DYNC1I2 -0.92 -12.98 -0.62 3.66e-30 Schizophrenia; CESC cis rs1215050 0.740 rs1214994 chr4:99035577 C/T cg05340658 chr4:99064831 C4orf37 0.57 7.59 0.42 5.49e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs722599 0.748 rs731952 chr14:75366447 A/G cg08847533 chr14:75593920 NEK9 0.42 5.1 0.3 6.62e-7 IgG glycosylation; CESC trans rs11098499 0.955 rs4145951 chr4:120155817 A/G cg25214090 chr10:38739885 LOC399744 0.65 8.59 0.47 7.54e-16 Corneal astigmatism; CESC cis rs9911578 1.000 rs10401050 chr17:56953786 A/C cg12560992 chr17:57184187 TRIM37 0.94 15.65 0.69 1.5e-39 Intelligence (multi-trait analysis); CESC cis rs6748734 0.625 rs6741220 chr2:241822432 C/T cg04034577 chr2:241836375 C2orf54 0.33 5.97 0.34 7.67e-9 Urinary metabolites; CESC cis rs9322193 0.962 rs35443312 chr6:149991761 T/C cg13206674 chr6:150067644 NUP43 0.39 5.41 0.32 1.42e-7 Lung cancer; CESC cis rs7301826 0.651 rs7132657 chr12:131285187 T/C cg11011512 chr12:131303247 STX2 0.47 5.81 0.34 1.81e-8 Plasma plasminogen activator levels; CESC trans rs2207136 0.835 rs2817351 chr6:50897613 A/G cg06522515 chr3:184090630 THPO -0.35 -6.04 -0.35 5.31e-9 Myopia; CESC cis rs1023500 0.596 rs5758562 chr22:42448238 C/G cg04733989 chr22:42467013 NAGA 0.81 11.08 0.56 1.09e-23 Schizophrenia; CESC cis rs2766692 0.843 rs10873515 chr14:100766664 C/T cg14866419 chr14:100704911 YY1 -0.42 -5.1 -0.3 6.63e-7 Electroencephalographic traits in alcoholism; CESC cis rs7714584 1.000 rs1896707 chr5:150245129 C/T cg22134413 chr5:150180641 NA 0.49 5.65 0.33 4.22e-8 Crohn's disease; CESC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.06 0.4 1.5e-11 Height; CESC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg16325326 chr1:53192061 ZYG11B -0.94 -16.08 -0.7 4.45e-41 Monocyte count; CESC cis rs6964587 1.000 rs6976122 chr7:91610962 T/C cg17063962 chr7:91808500 NA 0.57 7.74 0.43 2.11e-13 Breast cancer; CESC cis rs10089 0.953 rs10045113 chr5:127386631 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.53 0.54 6.98e-22 Ileal carcinoids; CESC cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg04972856 chr6:88032051 C6orf162;GJB7 0.33 5.49 0.32 9.58e-8 Monocyte percentage of white cells; CESC cis rs12137294 0.866 rs1078362 chr1:205209530 A/G cg21643547 chr1:205240462 TMCC2 -0.35 -5.66 -0.33 4e-8 Red cell distribution width; CESC cis rs9649213 0.614 rs3801258 chr7:97988428 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.45 -6.1 -0.35 3.72e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg23129613 chr7:150065255 REPIN1 0.48 6.39 0.37 7.42e-10 Systemic lupus erythematosus; CESC cis rs12541635 0.966 rs7839239 chr8:107020406 C/T cg10147462 chr8:107024639 NA 0.41 5.98 0.34 7.16e-9 Age of smoking initiation; CESC cis rs1499614 1.000 rs1267817 chr7:66110040 G/T cg08632164 chr7:65971372 NA -0.49 -5.15 -0.3 5.03e-7 Gout; CESC cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs10067021 chr5:221490 C/T cg22857025 chr5:266934 NA -1.27 -18.89 -0.76 5.51e-51 Breast cancer; CESC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg26314531 chr2:26401878 FAM59B -0.81 -9.01 -0.48 4.3e-17 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26782824 chr11:82867961 PCF11 -0.46 -6.47 -0.37 4.78e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 11.43 0.57 7.11e-25 Platelet count; CESC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg11764359 chr7:65958608 NA -0.65 -8.46 -0.46 1.78e-15 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12612340 chr11:47664330 MTCH2 0.59 6.66 0.38 1.61e-10 Gut microbiome composition (summer); CESC cis rs3106136 0.872 rs10030713 chr4:95238536 C/G cg11021082 chr4:95130006 SMARCAD1 -0.41 -5.66 -0.33 3.85e-8 Capecitabine sensitivity; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25433267 chr10:77161647 C10orf41;ZNF503 -0.53 -6.52 -0.37 3.45e-10 Ulcerative colitis; CESC cis rs763014 0.833 rs3743902 chr16:632728 T/C cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21242327 chr4:57829539 C4orf14 -0.4 -6.09 -0.35 3.99e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19558860 chr14:93582779 ITPK1 -0.47 -6.33 -0.36 1.02e-9 Ulcerative colitis; CESC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.65 0.38 1.65e-10 Electroencephalogram traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01579086 chr17:40719412 MLX 0.52 6.78 0.38 7.88e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg08859206 chr1:53392774 SCP2 -0.64 -9.56 -0.51 8.45e-19 Monocyte count; CESC cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg16447950 chr5:562315 NA -0.71 -7.83 -0.43 1.2e-13 Lung disease severity in cystic fibrosis; CESC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg25251562 chr2:3704773 ALLC -0.59 -5.75 -0.33 2.5e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg20891283 chr12:69753455 YEATS4 0.9 14.79 0.67 1.71e-36 Blood protein levels; CESC cis rs9596863 1.000 rs9536564 chr13:54460395 G/A ch.13.53330881F chr13:54432880 NA -0.67 -5.68 -0.33 3.5e-8 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC trans rs11088226 0.681 rs11702499 chr21:33938565 C/T cg09050820 chr6:167586206 TCP10L2 0.83 7.75 0.43 2.01e-13 Gastritis; CESC cis rs2279817 1.000 rs2279817 chr1:18021858 T/C cg21791023 chr1:18019539 ARHGEF10L -0.63 -8.42 -0.46 2.44e-15 Neuroticism; CESC cis rs7786877 0.521 rs4729606 chr7:100321790 T/C cg16850897 chr7:100343110 ZAN -0.63 -7.75 -0.43 2.02e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7246865 0.906 rs2278997 chr19:17166981 G/A cg19418318 chr19:17219073 MYO9B 0.32 5.32 0.31 2.17e-7 Reticulocyte fraction of red cells; CESC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg25517755 chr10:38738941 LOC399744 -0.44 -5.76 -0.33 2.29e-8 Extrinsic epigenetic age acceleration; CESC cis rs9457247 0.967 rs443570 chr6:167389925 G/A cg23791538 chr6:167370224 RNASET2 -0.63 -8.95 -0.48 6.25e-17 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14163802 chr2:206547479 NRP2 0.58 6.64 0.38 1.78e-10 Gut microbiome composition (summer); CESC cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.74 9.36 0.5 3.58e-18 Multiple sclerosis; CESC cis rs7662987 0.517 rs2602872 chr4:100038996 A/G cg12011299 chr4:100065546 ADH4 0.57 6.32 0.36 1.09e-9 Smoking initiation; CESC cis rs2239547 0.522 rs2581801 chr3:52972907 G/T cg11645453 chr3:52864694 ITIH4 -0.31 -5.17 -0.3 4.6e-7 Schizophrenia; CESC cis rs7631605 0.905 rs6796088 chr3:37147572 G/T cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.07 -0.3 7.57e-7 Cerebrospinal P-tau181p levels; CESC cis rs17376456 0.877 rs12153788 chr5:93405437 A/G cg25358565 chr5:93447407 FAM172A 1.13 10.9 0.56 4.33e-23 Diabetic retinopathy; CESC cis rs3857067 0.776 rs6858265 chr4:95112565 A/G cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC trans rs9951602 0.512 rs6506872 chr18:76649695 T/C cg02800362 chr5:177631904 HNRNPAB 0.65 8.64 0.47 5.23e-16 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.62 -7.17 -0.4 7.36e-12 Gut microbiome composition (summer); CESC cis rs7116495 0.609 rs2735787 chr11:71717873 T/C cg18441811 chr11:71824068 C11orf51 -0.78 -5.19 -0.3 4.26e-7 Severe influenza A (H1N1) infection; CESC cis rs7927592 0.913 rs7118897 chr11:68360680 G/A cg20283391 chr11:68216788 NA -0.59 -7.4 -0.41 1.85e-12 Total body bone mineral density; CESC cis rs11051970 0.559 rs56670459 chr12:32543325 G/A cg24626660 chr12:32551988 NA 0.42 5.37 0.31 1.7e-7 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07649988 chr10:102106576 SCD 0.55 6.06 0.35 4.55e-9 Gut microbiome composition (summer); CESC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg25985355 chr7:65971099 NA 0.32 5.23 0.31 3.53e-7 Aortic root size; CESC cis rs8018808 0.875 rs7250 chr14:77935520 G/A cg20045696 chr14:77926864 AHSA1 0.43 5.9 0.34 1.13e-8 Myeloid white cell count; CESC cis rs9911578 1.000 rs9897326 chr17:56902297 A/G cg12560992 chr17:57184187 TRIM37 0.94 15.75 0.7 6.57e-40 Intelligence (multi-trait analysis); CESC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.1e-18 Prudent dietary pattern; CESC cis rs60871478 1.000 rs60871478 chr7:827325 A/G cg05535760 chr7:792225 HEATR2 0.86 10.68 0.55 2.27e-22 Cerebrospinal P-tau181p levels; CESC cis rs1577917 0.958 rs12196377 chr6:86566775 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.14 -0.35 2.93e-9 Response to antipsychotic treatment; CESC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg05863683 chr7:1912471 MAD1L1 0.36 5.36 0.31 1.84e-7 Bipolar disorder and schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00753739 chr10:11653489 USP6NL 0.5 6.34 0.36 9.83e-10 Gut microbiota (bacterial taxa); CESC cis rs7312933 0.531 rs2708059 chr12:42851008 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.37 -0.36 8.42e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs2120019 0.608 rs4886414 chr15:75308650 C/T cg00629941 chr15:75287862 SCAMP5 0.53 6.32 0.36 1.12e-9 Blood trace element (Zn levels); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22501760 chr22:29137527 CHEK2;HSCB 0.45 6.11 0.35 3.49e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg11644478 chr21:40555479 PSMG1 -0.57 -7.68 -0.43 2.98e-13 Menarche (age at onset); CESC cis rs3820928 0.874 rs11685983 chr2:227799853 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -5.62 -0.33 4.72e-8 Pulmonary function; CESC cis rs55788414 0.932 rs12103301 chr16:81181423 A/C cg06400318 chr16:81190750 PKD1L2 -0.58 -6.86 -0.39 4.78e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs360798 0.512 rs2058566 chr2:63179076 C/T cg17519650 chr2:63277830 OTX1 0.53 6.54 0.37 3.21e-10 Coronary artery disease; CESC cis rs7147624 1.000 rs10873192 chr14:66110653 A/G cg03016385 chr14:66212404 NA -0.54 -5.34 -0.31 1.96e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs7589342 0.831 rs13429270 chr2:106453060 C/T cg16077055 chr2:106428750 NCK2 0.5 7.04 0.4 1.68e-11 Addiction; CESC cis rs7520050 0.966 rs11211208 chr1:46334256 A/C cg24296786 chr1:45957014 TESK2 0.42 5.35 0.31 1.89e-7 Red blood cell count;Reticulocyte count; CESC cis rs910316 0.737 rs175080 chr14:75513828 G/A cg16144293 chr14:75469539 EIF2B2 0.39 5.11 0.3 6.21e-7 Height; CESC cis rs2929278 0.617 rs3087657 chr15:44063859 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.48 6.1 0.35 3.82e-9 Schizophrenia; CESC trans rs877282 0.838 rs34778553 chr10:796865 T/C cg22713356 chr15:30763199 NA 1.32 13.53 0.64 4.55e-32 Uric acid levels; CESC cis rs78889164 0.876 rs78134016 chr19:33855373 C/T cg02272751 chr19:33882848 PEPD -0.47 -6.34 -0.36 9.92e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs3096299 0.748 rs3102339 chr16:89442711 C/T cg08822215 chr16:89438651 ANKRD11 -0.42 -6.25 -0.36 1.59e-9 Multiple myeloma (IgH translocation); CESC cis rs16854884 0.586 rs6440212 chr3:143748526 T/C cg01302019 chr3:143689584 C3orf58 -0.32 -5.07 -0.3 7.32e-7 Economic and political preferences (feminism/equality); CESC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.87 0.62 9.38e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg01475377 chr6:109611718 NA -0.42 -6.43 -0.37 6.01e-10 Reticulocyte fraction of red cells; CESC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -7.11 -0.4 1.1e-11 Developmental language disorder (linguistic errors); CESC cis rs10883723 0.810 rs13287 chr10:104240438 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.56 7.7 0.43 2.73e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs367943 1.000 rs460079 chr5:112800525 G/A cg12552261 chr5:112820674 MCC -0.6 -7.04 -0.4 1.68e-11 Type 2 diabetes; CESC cis rs5750830 0.594 rs5757647 chr22:39775047 C/A cg05872129 chr22:39784769 NA -0.75 -10.71 -0.55 1.76e-22 Intelligence (multi-trait analysis); CESC cis rs826838 1.000 rs1843881 chr12:38733706 A/G cg13010199 chr12:38710504 ALG10B -0.61 -8.73 -0.47 2.95e-16 Heart rate; CESC cis rs5769765 0.955 rs5770750 chr22:50276828 A/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.14 0.4 9.06e-12 Bipolar disorder; CESC cis rs12477438 0.798 rs9308816 chr2:99637230 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.74 -0.55 1.39e-22 Chronic sinus infection; CESC cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg24110177 chr3:50126178 RBM5 -0.54 -7.23 -0.41 5.19e-12 Intelligence (multi-trait analysis); CESC cis rs698833 0.926 rs1067399 chr2:44678648 A/G cg04920474 chr2:44395004 PPM1B 0.37 5.29 0.31 2.6e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs11690935 0.531 rs4280428 chr2:172813219 G/A cg13550731 chr2:172543902 DYNC1I2 0.46 6.37 0.36 8.38e-10 Schizophrenia; CESC cis rs12477438 0.520 rs6542863 chr2:99725138 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.87 0.7 2.48e-40 Chronic sinus infection; CESC cis rs11098499 0.644 rs3806808 chr4:120551085 A/C cg09307838 chr4:120376055 NA 0.74 9.81 0.52 1.4e-19 Corneal astigmatism; CESC cis rs9911578 1.000 rs9807057 chr17:56889952 A/C cg12560992 chr17:57184187 TRIM37 0.92 15.58 0.69 2.71e-39 Intelligence (multi-trait analysis); CESC cis rs28673728 0.868 rs28380108 chr1:38409103 G/C cg12658694 chr1:38397304 INPP5B 0.64 9.27 0.49 6.76e-18 Red cell distribution width; CESC cis rs8018808 1.000 rs35881785 chr14:77873571 C/T cg20045696 chr14:77926864 AHSA1 0.38 5.18 0.3 4.49e-7 Myeloid white cell count; CESC cis rs75477785 1.000 rs1883332 chr1:210046786 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.8 5.16 0.3 4.87e-7 Cleft lip with or without cleft palate; CESC cis rs7219021 0.739 rs3760451 chr17:46969177 G/A cg16584676 chr17:46985605 UBE2Z -0.65 -7.82 -0.43 1.24e-13 Schizophrenia or bipolar disorder; CESC cis rs2985684 1.000 rs1957977 chr14:50090603 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.48 -5.66 -0.33 3.97e-8 Carotid intima media thickness; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09258082 chr22:41791815 TEF -0.47 -6.15 -0.35 2.82e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg06808227 chr14:105710500 BRF1 -0.57 -6.63 -0.38 1.85e-10 Mean platelet volume;Platelet distribution width; CESC cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg24549020 chr5:56110836 MAP3K1 -0.51 -6.28 -0.36 1.4e-9 Initial pursuit acceleration; CESC cis rs11722228 1.000 rs11722228 chr4:9915741 C/T cg11266682 chr4:10021025 SLC2A9 0.46 7.76 0.43 1.81e-13 Gout;Urate levels;Serum uric acid levels; CESC cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg07636037 chr3:49044803 WDR6 -0.99 -14.57 -0.67 1.01e-35 Parkinson's disease; CESC cis rs9611565 0.512 rs139566 chr22:42199277 A/G cg03806693 chr22:41940476 POLR3H -1.14 -13.28 -0.63 3.33e-31 Vitiligo; CESC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg18402987 chr7:1209562 NA 0.59 7.03 0.4 1.79e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs601339 1.000 rs630408 chr12:123172822 C/T cg11919336 chr12:123188078 GPR109A 0.48 6.44 0.37 5.44e-10 Adiponectin levels; CESC cis rs9300255 0.596 rs7304782 chr12:123719444 A/G cg19016782 chr12:123741754 C12orf65 0.36 5.35 0.31 1.94e-7 Neutrophil percentage of white cells; CESC cis rs2732480 0.538 rs1387259 chr12:48703522 C/T cg24011408 chr12:48396354 COL2A1 -0.43 -5.91 -0.34 1.07e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg21593860 chr22:35796189 MCM5 0.48 6.05 0.35 5.05e-9 Attention deficit hyperactivity disorder; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10328259 chr2:3321226 TSSC1 -0.5 -6.6 -0.38 2.18e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.42 0.32 1.37e-7 Personality dimensions; CESC cis rs11871801 0.560 rs1905339 chr17:40582296 T/C cg21433558 chr17:40837037 CNTNAP1 0.46 5.96 0.34 8.13e-9 Crohn's disease; CESC cis rs11203032 0.831 rs4933494 chr10:90917892 T/A cg16672925 chr10:90967113 CH25H 0.75 6.89 0.39 4.02e-11 Heart failure; CESC cis rs1843834 0.755 rs11898692 chr2:225575173 T/C cg22455342 chr2:225449267 CUL3 0.45 5.69 0.33 3.28e-8 IgE levels in asthmatics (D.p. specific); CESC trans rs61931739 0.556 rs7954221 chr12:33825077 C/T cg26384229 chr12:38710491 ALG10B 0.5 7.41 0.41 1.71e-12 Morning vs. evening chronotype; CESC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg11644478 chr21:40555479 PSMG1 1.02 16.09 0.7 4.04e-41 Cognitive function; CESC cis rs7408868 0.706 rs2238642 chr19:15282237 T/C cg14696996 chr19:15285081 NOTCH3 0.83 9.44 0.5 1.97e-18 Pulse pressure; CESC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg22920501 chr2:26401640 FAM59B -0.67 -8.05 -0.44 2.86e-14 Gut microbiome composition (summer); CESC trans rs9369898 0.963 rs9381788 chr6:49413289 G/A cg15934674 chr1:150266645 MRPS21 -0.37 -6.03 -0.35 5.37e-9 Homocysteine levels; CESC cis rs12900413 0.645 rs28507224 chr15:90305393 T/C cg24249390 chr15:90295951 MESP1 -0.39 -5.33 -0.31 2.11e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs7617773 0.780 rs13081169 chr3:48356797 G/A cg11946769 chr3:48343235 NME6 0.89 12.23 0.6 1.46e-27 Coronary artery disease; CESC cis rs11969893 0.649 rs9498408 chr6:101292340 C/T cg12253828 chr6:101329408 ASCC3 0.95 8.4 0.46 2.76e-15 Economic and political preferences (immigration/crime); CESC cis rs12142240 0.698 rs41293285 chr1:46808426 C/T cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg23018236 chr17:30244563 NA -0.53 -5.14 -0.3 5.32e-7 Hip circumference adjusted for BMI; CESC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg23758822 chr17:41437982 NA 1.02 15.6 0.69 2.35e-39 Menopause (age at onset); CESC cis rs9814567 1.000 rs9832785 chr3:134213070 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.46 -6.29 -0.36 1.3e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9660992 0.762 rs1172130 chr1:205244953 G/A cg21643547 chr1:205240462 TMCC2 -0.46 -6.73 -0.38 1.05e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg06484146 chr7:12443880 VWDE -0.76 -10.38 -0.54 2.06e-21 Coronary artery disease; CESC cis rs9891119 0.811 rs744166 chr17:40514201 A/G cg21433558 chr17:40837037 CNTNAP1 0.37 5.19 0.3 4.25e-7 Multiple sclerosis;Crohn's disease; CESC cis rs921968 0.643 rs590771 chr2:219369851 C/T cg02176678 chr2:219576539 TTLL4 0.43 7.61 0.42 4.66e-13 Mean corpuscular hemoglobin concentration; CESC cis rs2204008 0.775 rs11514370 chr12:38305566 G/A cg13010199 chr12:38710504 ALG10B 0.42 5.42 0.32 1.37e-7 Bladder cancer; CESC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg24503407 chr1:205819492 PM20D1 -0.45 -6.28 -0.36 1.35e-9 White blood cell count (basophil);Basophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01139101 chr2:17492831 NA 0.49 6.27 0.36 1.42e-9 Gut microbiome composition (summer); CESC cis rs7267979 1.000 rs2500404 chr20:25359758 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -15.92 -0.7 1.72e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg08968635 chr6:28129556 ZNF389 0.42 5.75 0.33 2.45e-8 Depression; CESC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg22920501 chr2:26401640 FAM59B -0.63 -7.63 -0.42 4.24e-13 Gut microbiome composition (summer); CESC cis rs735860 0.763 rs6458912 chr6:53147965 G/A cg10236188 chr6:53219634 NA -0.34 -5.06 -0.3 7.77e-7 Glaucoma; CESC cis rs6964587 0.869 rs7793946 chr7:91520628 T/C cg17063962 chr7:91808500 NA -0.5 -6.62 -0.38 1.96e-10 Breast cancer; CESC cis rs57506017 0.606 rs12699324 chr7:12253372 T/C cg23422036 chr7:12250390 TMEM106B 0.39 5.21 0.3 3.76e-7 Neuroticism; CESC cis rs2204008 0.521 rs7311188 chr12:38542813 C/G cg26384229 chr12:38710491 ALG10B -0.45 -5.99 -0.35 6.97e-9 Bladder cancer; CESC cis rs11190604 0.945 rs11190553 chr10:102207959 T/C cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7584330 0.744 rs58223447 chr2:238378644 G/C cg14458575 chr2:238380390 NA 0.91 12.35 0.6 5.69e-28 Prostate cancer; CESC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC cis rs6772849 0.930 rs6768344 chr3:128373556 G/A cg16766828 chr3:128327626 NA -0.31 -5.08 -0.3 7.28e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg16049864 chr8:95962084 TP53INP1 -0.66 -11.64 -0.58 1.46e-25 Type 2 diabetes; CESC cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg02487422 chr3:49467188 NICN1 -0.5 -5.93 -0.34 9.65e-9 Parkinson's disease; CESC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg05863683 chr7:1912471 MAD1L1 0.46 6.96 0.39 2.67e-11 Bipolar disorder and schizophrenia; CESC cis rs735860 0.726 rs209519 chr6:53208680 G/A cg10236188 chr6:53219634 NA 0.35 5.23 0.31 3.48e-7 Glaucoma; CESC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg17372223 chr3:52568218 NT5DC2 0.44 6.63 0.38 1.88e-10 Bipolar disorder; CESC cis rs11792861 0.591 rs10979613 chr9:111687584 A/G cg13535736 chr9:111863775 C9orf5 -0.38 -5.58 -0.32 6.04e-8 Menarche (age at onset); CESC cis rs295140 0.605 rs3769471 chr2:201195403 G/A cg23649088 chr2:200775458 C2orf69 -0.43 -5.64 -0.33 4.41e-8 QT interval; CESC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.72 0.47 3.02e-16 Menopause (age at onset); CESC cis rs6758955 0.850 rs56261863 chr2:10480339 G/A cg15773312 chr2:10472214 HPCAL1 -0.45 -5.04 -0.3 8.65e-7 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs6432018 0.897 rs7556678 chr2:9755366 T/C cg23886495 chr2:9695866 ADAM17 0.44 5.12 0.3 5.91e-7 Heart rate variability traits; CESC cis rs2236918 0.710 rs1776138 chr1:242027075 G/A cg17736920 chr1:242011382 EXO1 0.56 7.18 0.4 6.97e-12 Menopause (age at onset); CESC trans rs1728785 1.000 rs1645936 chr16:68563743 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.51 6.53 0.37 3.42e-10 Ulcerative colitis; CESC cis rs7605827 0.930 rs9287664 chr2:15597116 A/G cg19274914 chr2:15703543 NA -0.32 -5.65 -0.33 4.2e-8 Educational attainment (years of education); CESC trans rs561341 1.000 rs113115092 chr17:30284164 G/A cg20587970 chr11:113659929 NA -1.43 -18.65 -0.75 3.85e-50 Hip circumference adjusted for BMI; CESC cis rs66573146 0.561 rs67245546 chr4:6947164 T/C cg00086871 chr4:6988644 TBC1D14 0.97 5.88 0.34 1.23e-8 Granulocyte percentage of myeloid white cells; CESC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg25036284 chr2:26402008 FAM59B -0.73 -8.35 -0.46 3.78e-15 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg27170947 chr2:26402098 FAM59B -0.84 -10.24 -0.53 5.89e-21 Gut microbiome composition (summer); CESC cis rs60871478 0.945 rs4719279 chr7:813618 T/C cg05535760 chr7:792225 HEATR2 0.88 10.83 0.55 7.1e-23 Cerebrospinal P-tau181p levels; CESC cis rs861020 0.630 rs655713 chr1:210006438 C/T cg05527609 chr1:210001259 C1orf107 0.74 9.67 0.51 3.97e-19 Orofacial clefts; CESC cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 2e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7772486 0.790 rs6917135 chr6:146152426 T/C cg23711669 chr6:146136114 FBXO30 0.9 13.27 0.63 3.71e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg13206674 chr6:150067644 NUP43 0.4 5.71 0.33 3.09e-8 Lung cancer; CESC cis rs11785400 0.762 rs9694556 chr8:143727841 A/G cg10596483 chr8:143751796 JRK 0.42 5.24 0.31 3.24e-7 Schizophrenia; CESC cis rs2204008 0.569 rs11495449 chr12:37995753 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.63 0.38 1.87e-10 Bladder cancer; CESC cis rs7927592 0.913 rs3758643 chr11:68367193 C/T cg20283391 chr11:68216788 NA -0.62 -7.43 -0.42 1.51e-12 Total body bone mineral density; CESC cis rs2531992 0.620 rs2041248 chr16:4032489 T/G cg05927578 chr16:4029543 ADCY9 0.56 6.99 0.39 2.26e-11 Waist circumference; CESC trans rs116095464 0.558 rs10067021 chr5:221490 C/T cg00938859 chr5:1591904 SDHAP3 0.6 6.66 0.38 1.55e-10 Breast cancer; CESC cis rs17867775 0.793 rs17864127 chr7:126730470 C/A cg02090654 chr7:126698344 MIR592;GRM8 0.68 5.04 0.3 8.68e-7 Anti-saccade response; CESC cis rs139156536 1 rs139156536 chr17:38164432 TTTTA/T cg17344932 chr17:38183730 MED24;SNORD124 -0.52 -7.4 -0.41 1.82e-12 Lymphocyte percentage of white cells; CESC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg19717773 chr7:2847554 GNA12 -0.48 -6.7 -0.38 1.25e-10 Height; CESC cis rs909674 0.734 rs5757675 chr22:39838892 G/T cg24399712 chr22:39784796 NA -0.81 -11.14 -0.56 6.68e-24 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs2996428 0.667 rs61768932 chr1:3765671 G/C cg10555106 chr1:3691387 LOC388588 0.39 5.13 0.3 5.73e-7 Red cell distribution width; CESC cis rs7216064 1.000 rs7208663 chr17:65885171 T/C cg07042672 chr17:66097459 LOC651250 -0.56 -6.52 -0.37 3.5e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg04944784 chr2:26401820 FAM59B 0.96 10.5 0.54 8.44e-22 Gut microbiome composition (summer); CESC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg18876405 chr7:65276391 NA 0.46 5.48 0.32 1.01e-7 Aortic root size; CESC cis rs10129255 0.957 rs11846893 chr14:107187307 T/C cg07958169 chr14:107095056 NA -0.42 -5.91 -0.34 1.05e-8 Kawasaki disease; CESC cis rs3733585 0.579 rs4235353 chr4:10122934 C/T cg11266682 chr4:10021025 SLC2A9 -0.57 -10.19 -0.53 8.72e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7631605 0.905 rs7620643 chr3:37152131 T/C cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.04 -0.3 8.48e-7 Cerebrospinal P-tau181p levels; CESC cis rs10129255 0.957 rs12590799 chr14:107187952 G/A cg07958169 chr14:107095056 NA -0.41 -5.69 -0.33 3.29e-8 Kawasaki disease; CESC cis rs763121 0.752 rs6001190 chr22:39073811 T/C cg21395723 chr22:39101663 GTPBP1 0.4 5.03 0.3 9.18e-7 Menopause (age at onset); CESC cis rs4588572 0.643 rs10474554 chr5:77799158 C/T cg11547950 chr5:77652471 NA -0.45 -5.62 -0.33 4.9e-8 Triglycerides; CESC trans rs8073060 0.544 rs17550716 chr17:33893208 A/G cg19694781 chr19:47549865 TMEM160 0.73 7.21 0.4 5.93e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs3820928 0.874 rs10182307 chr2:227875360 C/T cg11843606 chr2:227700838 RHBDD1 -0.46 -5.86 -0.34 1.36e-8 Pulmonary function; CESC cis rs9814567 0.964 rs9841180 chr3:134191880 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.61 -0.33 5.09e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs17253792 0.822 rs76819679 chr14:56134672 C/G cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs73206853 0.764 rs58535454 chr12:111003457 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.65 0.33 4.09e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs12995849 0.676 rs934306 chr2:106459654 C/A cg16077055 chr2:106428750 NCK2 0.4 5.9 0.34 1.08e-8 Addiction; CESC cis rs9914988 0.943 rs28847895 chr17:27172520 T/C cg20469991 chr17:27169893 C17orf63 -0.43 -5.15 -0.3 5.12e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10210571 chr1:231664364 TSNAX-DISC1;TSNAX 0.64 7.08 0.4 1.33e-11 Gut microbiome composition (summer); CESC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.58 0.37 2.57e-10 Electroencephalogram traits; CESC cis rs1008375 1.000 rs11724495 chr4:17621310 G/A cg16339924 chr4:17578868 LAP3 0.54 6.77 0.38 8.19e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg11764359 chr7:65958608 NA -0.72 -9.49 -0.5 1.36e-18 Aortic root size; CESC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg19774624 chr17:42201019 HDAC5 0.88 14.21 0.66 1.95e-34 Total body bone mineral density; CESC cis rs1707322 1.000 rs7553924 chr1:46352624 T/C cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg07701084 chr6:150067640 NUP43 0.44 5.99 0.35 6.96e-9 Lung cancer; CESC cis rs7635838 0.718 rs2606736 chr3:11400249 C/T cg00170343 chr3:11313890 ATG7 0.5 7.09 0.4 1.25e-11 HDL cholesterol; CESC cis rs7107174 1.000 rs11601196 chr11:78043431 A/C cg02023728 chr11:77925099 USP35 0.48 6.36 0.36 8.58e-10 Testicular germ cell tumor; CESC cis rs6987853 0.933 rs2974341 chr8:42398302 T/A cg09913449 chr8:42400586 C8orf40 0.39 6.13 0.35 3.15e-9 Mean corpuscular hemoglobin concentration; CESC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg24250549 chr1:154909240 PMVK 0.74 11.19 0.57 4.71e-24 Prostate cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10651300 chr12:53661859 ESPL1 -0.48 -6.17 -0.35 2.6e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs593982 0.920 rs618456 chr11:65475620 C/T cg08755490 chr11:65554678 OVOL1 1.19 11.15 0.57 6.14e-24 Atopic dermatitis; CESC cis rs763121 0.853 rs8138996 chr22:39047435 G/T cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC cis rs12478296 0.892 rs60042638 chr2:243038707 G/A cg06360820 chr2:242988706 NA -0.66 -7.52 -0.42 8.51e-13 Obesity-related traits; CESC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg25405998 chr7:65216604 CCT6P1 0.48 5.59 0.32 5.67e-8 Aortic root size; CESC cis rs2370759 1.000 rs79487858 chr10:32616405 T/C cg18270830 chr10:32634957 EPC1 0.71 6.78 0.38 7.78e-11 Sexual dysfunction (female); CESC cis rs8020095 0.571 rs7147690 chr14:67242337 C/G cg19548862 chr14:67692701 FAM71D 0.5 6.13 0.35 3.14e-9 Depression (quantitative trait); CESC cis rs6669008 1.000 rs1891969 chr1:114185855 C/A cg26035817 chr1:114414802 PTPN22 0.43 6.21 0.36 2.09e-9 Bacteremia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09275602 chr7:66370330 NA -0.56 -6.31 -0.36 1.16e-9 Gut microbiome composition (summer); CESC cis rs9457247 0.663 rs2282861 chr6:167440128 C/T cg25258033 chr6:167368657 RNASET2 0.37 5.4 0.31 1.51e-7 Crohn's disease; CESC cis rs12887734 0.566 rs3742366 chr14:104198351 T/C cg08213375 chr14:104286397 PPP1R13B 0.43 7.2 0.4 6.36e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs8114671 0.552 rs2024635 chr20:33422614 G/A cg24642439 chr20:33292090 TP53INP2 0.46 5.5 0.32 9.07e-8 Height; CESC cis rs9911578 1.000 rs9807057 chr17:56889952 A/C cg05425664 chr17:57184151 TRIM37 -0.49 -6.87 -0.39 4.62e-11 Intelligence (multi-trait analysis); CESC cis rs1461503 0.966 rs7113725 chr11:122843511 G/T cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg25767906 chr1:53392781 SCP2 -0.54 -7.54 -0.42 7.6e-13 Monocyte count; CESC cis rs2859741 0.546 rs3934329 chr1:37504523 C/T cg09363841 chr1:37513479 NA -0.54 -8.0 -0.44 3.96e-14 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs2243480 1.000 rs1715235 chr7:65488394 T/C cg25894440 chr7:65020034 NA -0.65 -5.63 -0.33 4.5e-8 Diabetic kidney disease; CESC cis rs61931739 0.817 rs592857 chr12:34197673 T/G cg19457237 chr12:34500585 NA -0.39 -5.33 -0.31 2.15e-7 Morning vs. evening chronotype; CESC cis rs61776719 0.520 rs11485595 chr1:38411350 C/T cg18451016 chr1:38461880 NA 0.4 5.94 0.34 8.96e-9 Coronary artery disease; CESC cis rs4836694 0.574 rs3780712 chr9:132943082 A/G cg05251000 chr9:132935664 FREQ 0.41 5.43 0.32 1.27e-7 Alzheimer's disease (cognitive decline); CESC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg14393609 chr7:65229607 NA -0.47 -6.32 -0.36 1.08e-9 Aortic root size; CESC trans rs9467711 0.606 rs9358937 chr6:26374274 C/G cg06606381 chr12:133084897 FBRSL1 -0.75 -6.61 -0.38 2.1e-10 Autism spectrum disorder or schizophrenia; CESC cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg05340658 chr4:99064831 C4orf37 0.77 11.85 0.59 2.88e-26 Colonoscopy-negative controls vs population controls; CESC cis rs3105593 0.933 rs3101850 chr15:50844314 A/G cg08437265 chr15:50716283 USP8 0.45 5.74 0.33 2.63e-8 QT interval; CESC cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.66 0.61 4.8e-29 Colonoscopy-negative controls vs population controls; CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg18402987 chr7:1209562 NA 0.49 6.68 0.38 1.4e-10 Longevity;Endometriosis; CESC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg21433313 chr16:3507492 NAT15 -0.61 -6.53 -0.37 3.24e-10 Tuberculosis; CESC cis rs9354308 0.899 rs2814099 chr6:66555130 A/G cg07460842 chr6:66804631 NA 0.61 6.93 0.39 3.29e-11 Metabolite levels; CESC cis rs7264396 0.563 rs2425109 chr20:34316218 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.74 -0.55 1.38e-22 Total cholesterol levels; CESC cis rs116095464 0.558 rs10462754 chr5:246669 T/C cg22857025 chr5:266934 NA -1.28 -18.26 -0.75 8.94e-49 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00357671 chr12:124809516 NCOR2 0.49 6.54 0.37 3.16e-10 Fibrinogen levels; CESC cis rs9790314 1.000 rs28515190 chr3:161028605 G/A cg03342759 chr3:160939853 NMD3 -0.47 -6.09 -0.35 3.99e-9 Morning vs. evening chronotype; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06506598 chr5:79783889 FAM151B -0.47 -6.57 -0.37 2.59e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9929218 1.000 rs7186084 chr16:68816260 C/G cg02972257 chr16:68554789 NA -0.46 -5.47 -0.32 1.03e-7 Colorectal cancer; CESC cis rs6570726 0.720 rs412623 chr6:145883257 C/A cg23711669 chr6:146136114 FBXO30 0.87 12.81 0.62 1.49e-29 Lobe attachment (rater-scored or self-reported); CESC trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21659725 chr3:3221576 CRBN -0.82 -13.58 -0.64 3.15e-32 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15109179 chr17:41323082 NBR1 0.64 7.11 0.4 1.07e-11 Gut microbiome composition (summer); CESC cis rs7511006 1.000 rs5771109 chr22:50678571 T/C cg07895657 chr22:50616420 PANX2 -0.36 -5.11 -0.3 6.05e-7 Obesity-related traits; CESC cis rs36093924 0.646 rs7285557 chr22:42348790 T/C cg15557168 chr22:42548783 NA 0.36 5.25 0.31 3.18e-7 Intelligence; CESC cis rs72781680 1.000 rs75046532 chr2:24167267 A/G cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs4253772 0.938 rs41378347 chr22:46636976 G/A cg00784671 chr22:46762841 CELSR1 -0.51 -5.29 -0.31 2.54e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7827545 0.545 rs16905172 chr8:135556373 A/G cg17885191 chr8:135476712 NA 0.53 6.09 0.35 4.05e-9 Hypertension (SNP x SNP interaction); CESC cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg04455712 chr21:45112962 RRP1B 0.4 6.14 0.35 3.04e-9 Mean corpuscular volume; CESC cis rs6456156 0.586 rs13208636 chr6:167461965 T/G cg07741184 chr6:167504864 NA 0.35 6.08 0.35 4.1e-9 Primary biliary cholangitis; CESC cis rs1538970 1.000 rs11211101 chr1:45849311 C/G cg03146154 chr1:46216737 IPP 0.44 5.37 0.31 1.75e-7 Platelet count; CESC cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg23711669 chr6:146136114 FBXO30 1.01 15.9 0.7 2.05e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs2228479 0.850 rs62054257 chr16:89900195 G/A cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg05234568 chr11:5960015 NA -0.55 -6.43 -0.37 5.77e-10 DNA methylation (variation); CESC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg11890956 chr21:40555474 PSMG1 1.17 21.83 0.8 3.83e-61 Cognitive function; CESC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg08392591 chr16:89556376 ANKRD11 0.59 8.07 0.44 2.52e-14 Multiple myeloma (IgH translocation); CESC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.18e-7 Aortic root size; CESC trans rs7246760 1.000 rs59867671 chr19:9933558 G/C cg02900749 chr2:68251473 NA -0.8 -6.75 -0.38 9.06e-11 Pursuit maintenance gain; CESC cis rs668210 0.793 rs540584 chr11:65765866 C/G cg02202077 chr11:65769826 EIF1AD;BANF1 -0.67 -6.49 -0.37 4.16e-10 Cerebrospinal fluid biomarker levels; CESC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg03676636 chr4:99064102 C4orf37 0.35 5.22 0.31 3.66e-7 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21800906 chr11:32914818 QSER1 -0.46 -6.7 -0.38 1.26e-10 Gambling; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04604752 chr16:1570881 IFT140 0.45 6.13 0.35 3.25e-9 Fibrinogen levels; CESC cis rs4253772 0.530 rs9615349 chr22:46732418 T/G cg18190219 chr22:46762943 CELSR1 -0.67 -6.16 -0.35 2.71e-9 LDL cholesterol;Cholesterol, total; CESC cis rs875971 0.662 rs448725 chr7:65514628 A/G cg12463550 chr7:65579703 CRCP 0.59 7.47 0.42 1.16e-12 Aortic root size; CESC trans rs17685 0.753 rs10085567 chr7:75734206 A/C cg19862616 chr7:65841803 NCRNA00174 0.83 11.96 0.59 1.23e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs644799 0.965 rs549695 chr11:95617788 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.84 12.05 0.59 6.06e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.21 -0.36 2.01e-9 Schizophrenia; CESC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg12463550 chr7:65579703 CRCP -0.46 -5.81 -0.34 1.76e-8 Aortic root size; CESC cis rs7733403 1 rs7733403 chr5:140154215 A/G cg26395211 chr5:140044315 WDR55 -0.41 -5.16 -0.3 4.91e-7 Schizophrenia; CESC cis rs2832191 1.000 rs6516891 chr21:30483070 C/T cg24692254 chr21:30365293 RNF160 -0.74 -11.15 -0.57 6.22e-24 Dental caries; CESC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.15 0.3 5.06e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7216064 0.817 rs12603589 chr17:65825248 T/C cg12091567 chr17:66097778 LOC651250 -0.87 -8.62 -0.47 6.33e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9911578 0.817 rs304264 chr17:56749628 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.06 0.3 8.03e-7 Intelligence (multi-trait analysis); CESC cis rs6456156 0.819 rs9457273 chr6:167520749 A/T cg23791538 chr6:167370224 RNASET2 0.45 5.87 0.34 1.33e-8 Primary biliary cholangitis; CESC cis rs1692580 0.870 rs590367 chr1:2162944 C/T cg04315214 chr1:2043799 PRKCZ -0.39 -5.64 -0.33 4.43e-8 Coronary artery disease; CESC cis rs2346177 0.519 rs2121698 chr2:46709571 C/T cg02822958 chr2:46747628 ATP6V1E2 0.45 5.59 0.32 5.72e-8 HDL cholesterol; CESC cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7605827 0.930 rs12993042 chr2:15708218 A/T cg19274914 chr2:15703543 NA 0.29 5.22 0.31 3.7e-7 Educational attainment (years of education); CESC cis rs11792861 0.566 rs67780641 chr9:111850710 A/G cg05043794 chr9:111880884 C9orf5 -0.29 -5.13 -0.3 5.62e-7 Menarche (age at onset); CESC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg12463550 chr7:65579703 CRCP 0.49 6.24 0.36 1.69e-9 Aortic root size; CESC cis rs17384381 0.953 rs12139958 chr1:85842112 A/G cg16011679 chr1:85725395 C1orf52 0.79 8.08 0.44 2.34e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg17366294 chr4:99064904 C4orf37 0.59 7.74 0.43 2.15e-13 Colonoscopy-negative controls vs population controls; CESC cis rs7824557 0.564 rs2572395 chr8:11235360 A/C cg21775007 chr8:11205619 TDH -0.53 -7.9 -0.44 7.62e-14 Retinal vascular caliber; CESC cis rs2635047 0.519 rs2668771 chr18:44775897 G/A cg24371990 chr18:44770781 NA 0.34 5.46 0.32 1.1e-7 Educational attainment; CESC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg03467027 chr4:99064603 C4orf37 0.48 6.15 0.35 2.83e-9 Colonoscopy-negative controls vs population controls; CESC cis rs8072100 0.713 rs9899859 chr17:45513049 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -5.43 -0.32 1.26e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9487051 0.714 rs9487058 chr6:109631060 A/C cg12927641 chr6:109611667 NA -0.37 -5.51 -0.32 8.68e-8 Reticulocyte fraction of red cells; CESC cis rs870825 0.616 rs28558715 chr4:185627761 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs2228479 0.702 rs17233868 chr16:89803629 C/T cg00800038 chr16:89945340 TCF25 -0.79 -6.4 -0.37 6.93e-10 Skin colour saturation; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg27612744 chr5:16465883 ZNF622 -0.47 -6.03 -0.35 5.36e-9 Ulcerative colitis; CESC cis rs7144547 0.803 rs8008602 chr14:81890171 T/A cg23690444 chr14:81902736 NA 0.73 7.67 0.43 3.27e-13 Prudent dietary pattern; CESC cis rs1957429 0.731 rs1951495 chr14:65336690 T/C cg23373153 chr14:65346875 NA 1.01 8.81 0.48 1.72e-16 Pediatric areal bone mineral density (radius); CESC cis rs11190604 1.000 rs10883504 chr10:102280687 G/A cg07080220 chr10:102295463 HIF1AN 0.67 6.17 0.35 2.58e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg18016565 chr1:150552671 MCL1 0.33 5.03 0.3 8.96e-7 Melanoma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27380774 chr11:1000560 AP2A2 0.51 6.99 0.39 2.18e-11 Fibrinogen levels; CESC cis rs1801251 0.964 rs10933411 chr2:233706847 A/G cg08000102 chr2:233561755 GIGYF2 -0.7 -10.07 -0.53 2.08e-20 Coronary artery disease; CESC trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21659725 chr3:3221576 CRBN -0.83 -13.61 -0.64 2.43e-32 Intelligence (multi-trait analysis); CESC cis rs7927771 0.832 rs7105851 chr11:47383275 T/C cg05585544 chr11:47624801 NA 0.48 7.02 0.4 1.89e-11 Subjective well-being; CESC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg14926445 chr8:58193284 C8orf71 -0.49 -5.18 -0.3 4.44e-7 Developmental language disorder (linguistic errors); CESC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs79387448 0.638 rs11465670 chr2:103034440 A/G cg09003973 chr2:102972529 NA 0.88 7.51 0.42 8.92e-13 Gut microbiota (bacterial taxa); CESC cis rs8062405 0.755 rs62034350 chr16:28562256 A/G cg07382826 chr16:28625726 SULT1A1 0.41 6.71 0.38 1.15e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs35110281 0.774 rs2838323 chr21:44999086 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 6.56 0.37 2.83e-10 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25368943 chr5:93905257 MIR1974;C5orf36 -0.53 -6.3 -0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg14416269 chr4:6271139 WFS1 0.45 7.27 0.41 4.07e-12 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6088580 0.634 rs6088508 chr20:33060081 A/G cg08999081 chr20:33150536 PIGU 0.66 11.59 0.58 2.04e-25 Glomerular filtration rate (creatinine); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09042752 chr12:105500971 KIAA1033 -0.47 -6.27 -0.36 1.44e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg13628971 chr7:2884303 GNA12 0.43 5.74 0.33 2.58e-8 Height; CESC cis rs453301 0.562 rs1038248 chr8:9040858 G/T cg15556689 chr8:8085844 FLJ10661 -0.42 -5.16 -0.3 4.96e-7 Joint mobility (Beighton score); CESC cis rs9467711 0.606 rs9379852 chr6:26357278 A/G cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.52e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7666738 0.830 rs13141752 chr4:98893128 G/A cg05340658 chr4:99064831 C4orf37 0.75 11.14 0.56 6.81e-24 Colonoscopy-negative controls vs population controls; CESC cis rs8060686 0.565 rs75286242 chr16:68145798 C/T cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 4.92e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs11122272 0.735 rs2790891 chr1:231513190 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs3845702 0.800 rs6744281 chr2:180844382 G/A cg01881094 chr2:180872142 CWC22 -1.02 -9.36 -0.5 3.69e-18 Schizophrenia; CESC trans rs9929218 0.954 rs10163398 chr16:68823124 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.13 -0.45 1.69e-14 Colorectal cancer; CESC cis rs11195062 0.805 rs10884942 chr10:112016926 A/G cg00817464 chr10:111662876 XPNPEP1 -0.38 -5.26 -0.31 3.03e-7 Multiple myeloma; CESC cis rs6062302 0.522 rs2872810 chr20:62241931 C/T cg09650180 chr20:62225654 GMEB2 0.82 9.38 0.5 3.04e-18 Glioblastoma; CESC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg10800226 chr5:1850261 NA 0.34 5.62 0.33 4.84e-8 Cardiovascular disease risk factors; CESC cis rs73206853 0.841 rs3893403 chr12:111083980 G/A cg12870014 chr12:110450643 ANKRD13A 0.64 5.24 0.31 3.23e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs4242434 0.927 rs34027561 chr8:22465385 T/C cg03733263 chr8:22462867 KIAA1967 0.96 14.94 0.68 5.09e-37 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs2455799 0.613 rs1969095 chr3:15733552 C/T cg16303742 chr3:15540471 COLQ -0.38 -6.09 -0.35 3.98e-9 Mean platelet volume; CESC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg26335602 chr6:28129616 ZNF389 -0.54 -7.17 -0.4 7.67e-12 Depression; CESC cis rs2180341 0.781 rs7742161 chr6:127571676 T/C cg27446573 chr6:127587934 RNF146 0.82 11.45 0.58 6.06e-25 Breast cancer; CESC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg04025307 chr7:1156635 C7orf50 0.43 5.98 0.34 7.37e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14831746 chr12:49961631 MCRS1 0.48 6.84 0.39 5.34e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg09338170 chr1:100436032 SLC35A3 0.44 6.48 0.37 4.41e-10 Positive affect; CESC cis rs753778 0.667 rs10092439 chr8:142210881 C/T cg23750338 chr8:142222470 SLC45A4 0.38 5.56 0.32 6.67e-8 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs826838 0.967 rs11183514 chr12:38760744 A/T cg13010199 chr12:38710504 ALG10B 0.62 8.74 0.47 2.7e-16 Heart rate; CESC cis rs9463078 0.817 rs3799967 chr6:44798701 A/G cg25276700 chr6:44698697 NA -0.34 -5.03 -0.3 9.05e-7 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs1729951 0.575 rs1654904 chr3:136681149 T/C cg25687071 chr3:136751404 NA 0.39 5.17 0.3 4.72e-7 Neuroticism; CESC trans rs1219407 0.655 rs1219392 chr11:121764234 A/G cg05493580 chr10:23569664 NA -0.48 -6.1 -0.35 3.66e-9 Mood disorder in prion disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10326224 chr17:60501257 METTL2A 0.62 6.5 0.37 4.04e-10 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg25036284 chr2:26402008 FAM59B -0.6 -6.94 -0.39 2.95e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 11.43 0.57 7.11e-25 Platelet count; CESC cis rs4450798 0.793 rs79204004 chr3:13758473 G/C cg05589046 chr3:13742034 LOC285375 0.38 5.8 0.34 1.86e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs151234 0.741 rs151227 chr16:28549508 C/T cg01378222 chr16:28622494 SULT1A1 -0.49 -6.55 -0.37 2.94e-10 Platelet distribution width; CESC cis rs116095464 0.558 rs62344300 chr5:246336 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.27 0.31 2.9e-7 Breast cancer; CESC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.67 0.47 4.35e-16 Colonoscopy-negative controls vs population controls; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg03205495 chr19:14640249 TECR;MIR639 -0.52 -6.9 -0.39 3.84e-11 Height; CESC cis rs9300255 0.506 rs61388686 chr12:123810873 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.11 -0.3 6.23e-7 Neutrophil percentage of white cells; CESC cis rs7000551 0.527 rs11783730 chr8:22244897 C/T cg12081754 chr8:22256438 SLC39A14 0.93 12.5 0.61 1.75e-28 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs4889855 0.530 rs72856551 chr17:78552267 G/T cg16591659 chr17:78472290 NA 0.35 5.74 0.33 2.63e-8 Fractional excretion of uric acid; CESC cis rs4642101 0.824 rs3889514 chr3:12844072 T/C cg05775895 chr3:12838266 CAND2 0.39 5.78 0.33 2.1e-8 QRS complex (12-leadsum); CESC cis rs28489187 0.730 rs12121675 chr1:85798484 A/G cg16011679 chr1:85725395 C1orf52 0.56 6.58 0.37 2.49e-10 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs6831352 0.918 rs4699713 chr4:100060513 C/T cg12011299 chr4:100065546 ADH4 -0.59 -6.59 -0.38 2.35e-10 Alcohol dependence; CESC trans rs11098499 1.000 rs12506395 chr4:120185094 C/T cg25214090 chr10:38739885 LOC399744 0.66 8.84 0.48 1.34e-16 Corneal astigmatism; CESC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg07256732 chr16:621771 PIGQ -0.32 -5.62 -0.33 4.94e-8 Height; CESC trans rs12681287 0.547 rs60982560 chr8:87515046 C/T cg27317242 chr8:23145699 R3HCC1 -0.51 -6.05 -0.35 4.96e-9 Caudate activity during reward; CESC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.61 5.71 0.33 3.02e-8 Lung function (FEV1/FVC); CESC cis rs909002 0.800 rs4949454 chr1:32099041 A/G cg13919466 chr1:32135498 COL16A1 0.45 8.06 0.44 2.55e-14 Intelligence (multi-trait analysis); CESC cis rs11711311 0.955 rs3796254 chr3:113380332 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.65 8.47 0.46 1.67e-15 IgG glycosylation; CESC cis rs11871801 0.517 rs668799 chr17:40716235 C/T cg21433558 chr17:40837037 CNTNAP1 0.47 5.76 0.33 2.29e-8 Crohn's disease; CESC cis rs30380 1.000 rs30187 chr5:96124330 T/C cg16492584 chr5:96139282 ERAP1 -0.34 -5.06 -0.3 7.84e-7 Cerebrospinal fluid biomarker levels; CESC cis rs2950393 0.794 rs1563897 chr12:57093100 T/C cg05584118 chr12:57595605 LRP1 -0.38 -5.38 -0.31 1.67e-7 Platelet distribution width; CESC cis rs7659604 0.521 rs13130789 chr4:122690166 G/A cg19748678 chr4:122722346 EXOSC9 -0.48 -6.07 -0.35 4.47e-9 Type 2 diabetes; CESC cis rs9549367 0.636 rs486407 chr13:113833499 G/A cg00898013 chr13:113819073 PROZ 0.46 6.9 0.39 3.73e-11 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25655593 chr20:48599521 SNAI1 -0.58 -6.66 -0.38 1.57e-10 Gut microbiome composition (summer); CESC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg26752003 chr8:145688521 CYHR1 0.6 8.07 0.44 2.48e-14 Age at first birth; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10656664 chr5:853447 NA -0.53 -6.59 -0.38 2.4e-10 Gut microbiome composition (summer); CESC cis rs8078723 0.714 rs2241245 chr17:38151014 C/T cg17467752 chr17:38218738 THRA -0.56 -8.52 -0.46 1.22e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs3820928 1.000 rs2396433 chr2:227772502 A/G cg11843606 chr2:227700838 RHBDD1 -0.43 -5.74 -0.33 2.55e-8 Pulmonary function; CESC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg05564831 chr3:52568323 NT5DC2 0.44 6.84 0.39 5.53e-11 Bipolar disorder; CESC cis rs9359856 0.564 rs72915944 chr6:90447226 C/T cg13799429 chr6:90582589 CASP8AP2 -0.64 -6.24 -0.36 1.77e-9 Bipolar disorder; CESC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg09877947 chr5:131593287 PDLIM4 0.43 5.22 0.31 3.54e-7 Acylcarnitine levels; CESC cis rs4925386 1.000 rs2151512 chr20:60913495 T/C cg22633769 chr20:60982531 CABLES2 -0.43 -5.12 -0.3 6.02e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26737766 chr1:24127303 GALE -0.44 -6.02 -0.35 5.68e-9 Gut microbiota (bacterial taxa); CESC cis rs977987 0.931 rs1834013 chr16:75496163 G/T cg03315344 chr16:75512273 CHST6 0.53 7.82 0.43 1.23e-13 Dupuytren's disease; CESC cis rs9457247 0.967 rs402191 chr6:167405553 T/C cg07741184 chr6:167504864 NA 0.29 5.31 0.31 2.32e-7 Crohn's disease; CESC cis rs57221529 0.709 rs72703090 chr5:598314 C/T cg16447950 chr5:562315 NA -0.59 -6.01 -0.35 6.18e-9 Lung disease severity in cystic fibrosis; CESC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg11301795 chr4:187892539 NA -0.72 -11.06 -0.56 1.3e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg14159672 chr1:205819179 PM20D1 0.79 11.62 0.58 1.62e-25 Menarche (age at onset); CESC cis rs7481584 0.624 rs412842 chr11:3047448 A/G cg25174290 chr11:3078921 CARS -0.46 -6.4 -0.37 6.86e-10 Calcium levels; CESC cis rs7605827 0.930 rs4140713 chr2:15536128 C/T cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs6688613 0.649 rs2280995 chr1:166846069 A/G ch.1.3259774R chr1:166827647 TADA1 0.54 5.24 0.31 3.25e-7 Refractive astigmatism; CESC cis rs9811920 0.965 rs10222474 chr3:99862551 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.44 7.02 0.4 1.9e-11 Axial length; CESC cis rs829880 0.789 rs1096146 chr12:98850966 A/G cg25150519 chr12:98850993 NA 0.8 11.66 0.58 1.27e-25 Colonoscopy-negative controls vs population controls; CESC cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg07697082 chr8:82753677 SNX16 0.39 5.94 0.34 8.74e-9 Diastolic blood pressure; CESC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg25072359 chr17:41440525 NA 0.43 5.83 0.34 1.61e-8 Menopause (age at onset); CESC cis rs8060686 0.844 rs3785100 chr16:67997920 T/C cg26727032 chr16:67993705 SLC12A4 -0.56 -6.18 -0.36 2.36e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27594834 chr19:11708137 ZNF627 -0.59 -6.49 -0.37 4.2e-10 Gut microbiome composition (summer); CESC cis rs2487048 0.761 rs2980083 chr9:107691362 A/C cg14470647 chr9:107690075 ABCA1 -0.57 -7.07 -0.4 1.36e-11 Intraocular pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20809690 chr4:2757764 TNIP2 -0.45 -6.65 -0.38 1.71e-10 Fibrinogen levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02432159 chr15:75661014 MAN2C1 0.42 6.08 0.35 4.07e-9 Systemic lupus erythematosus; CESC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg25405998 chr7:65216604 CCT6P1 0.46 5.37 0.31 1.72e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23202316 chr17:33447048 RAD51L3 -0.7 -8.87 -0.48 1.1e-16 Gut microbiome composition (summer); CESC cis rs6137287 0.668 rs6082331 chr20:21108350 A/G cg13880779 chr20:21376337 NKX2-4 0.34 5.51 0.32 8.43e-8 Height; CESC cis rs6691722 0.503 rs2274168 chr1:24707211 G/T cg18323236 chr1:24743029 NIPAL3 0.37 5.47 0.32 1.02e-7 Response to interferon beta in multiple sclerosis; CESC cis rs11958404 0.932 rs72816598 chr5:157436017 G/A cg05962755 chr5:157440814 NA 0.59 6.43 0.37 5.8e-10 IgG glycosylation; CESC cis rs2735413 0.881 rs12919818 chr16:78082862 C/T cg04733911 chr16:78082701 NA -0.53 -8.86 -0.48 1.17e-16 Systolic blood pressure (alcohol consumption interaction); CESC cis rs2273669 0.667 rs17070136 chr6:109350550 T/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.06 -0.35 4.74e-9 Prostate cancer; CESC cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.68 -9.89 -0.52 8.01e-20 Hip circumference adjusted for BMI; CESC cis rs2073300 0.609 rs77673953 chr20:23398794 G/C cg12062639 chr20:23401060 NAPB 1.06 8.32 0.46 4.59e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9443189 0.570 rs504446 chr6:76326939 T/C cg01950844 chr6:76311363 SENP6 0.87 9.39 0.5 2.95e-18 Prostate cancer; CESC cis rs9303280 0.628 rs12939565 chr17:38038389 A/T cg20243544 chr17:37824526 PNMT 0.54 7.15 0.4 8.36e-12 Self-reported allergy; CESC cis rs2997447 0.761 rs17257113 chr1:26449595 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.16 0.3 4.74e-7 QRS complex (12-leadsum); CESC cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg02487422 chr3:49467188 NICN1 0.42 5.36 0.31 1.78e-7 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19296153 chr4:1232112 CTBP1 -0.54 -6.09 -0.35 3.92e-9 Gut microbiome composition (summer); CESC cis rs7949030 0.590 rs12225213 chr11:62350248 T/A cg13298116 chr11:62369859 EML3;MTA2 0.64 9.22 0.49 9.73e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg13206674 chr6:150067644 NUP43 0.45 6.44 0.37 5.65e-10 Lung cancer; CESC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg05313129 chr8:58192883 C8orf71 -0.51 -5.07 -0.3 7.46e-7 Developmental language disorder (linguistic errors); CESC cis rs11785400 0.793 rs7459963 chr8:143737129 C/T cg10596483 chr8:143751796 JRK 0.43 5.45 0.32 1.14e-7 Schizophrenia; CESC cis rs9467711 0.606 rs9348709 chr6:26360311 G/A cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.52e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7772486 0.790 rs9485024 chr6:146142487 A/G cg05347473 chr6:146136440 FBXO30 -0.48 -5.89 -0.34 1.15e-8 Lobe attachment (rater-scored or self-reported); CESC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg23590916 chr17:43697445 MGC57346 -0.63 -6.59 -0.38 2.38e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7216064 1.000 rs8072225 chr17:65912960 A/G cg12091567 chr17:66097778 LOC651250 -0.7 -8.12 -0.45 1.72e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg01640444 chr3:193311744 OPA1 0.44 6.06 0.35 4.58e-9 Neuroticism; CESC cis rs2249625 0.967 rs2463725 chr6:72897212 C/T cg18830697 chr6:72922368 RIMS1 -0.44 -6.23 -0.36 1.86e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs6964587 0.692 rs12536220 chr7:91805595 T/G cg01689657 chr7:91764605 CYP51A1 0.27 5.37 0.31 1.69e-7 Breast cancer; CESC cis rs1707322 0.721 rs28641748 chr1:46212836 A/G cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg19592336 chr6:28129416 ZNF389 0.54 6.94 0.39 3e-11 Parkinson's disease; CESC cis rs2228479 0.850 rs62054599 chr16:89808850 C/G cg04013166 chr16:89971882 TCF25 0.77 6.69 0.38 1.32e-10 Skin colour saturation; CESC cis rs6088580 0.634 rs1890002 chr20:32919219 A/G cg08999081 chr20:33150536 PIGU -0.65 -11.31 -0.57 1.86e-24 Glomerular filtration rate (creatinine); CESC cis rs6448317 0.911 rs10939013 chr4:24903015 G/A cg21108841 chr4:24914750 CCDC149 0.49 6.08 0.35 4.25e-9 Heschl's gyrus morphology; CESC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.38 0.31 1.66e-7 Tonsillectomy; CESC cis rs17125944 0.505 rs10483618 chr14:53203590 T/C cg13660082 chr14:53194042 PSMC6 -0.65 -5.88 -0.34 1.23e-8 Alzheimer's disease (late onset); CESC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.97 0.34 7.51e-9 Colonoscopy-negative controls vs population controls; CESC cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg23803603 chr1:2058230 PRKCZ 0.33 5.76 0.33 2.37e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09686635 chr1:210001418 C1orf107 -0.58 -6.78 -0.38 7.82e-11 Gut microbiome composition (summer); CESC cis rs8060686 0.591 rs80346622 chr16:68074419 C/T cg26727032 chr16:67993705 SLC12A4 -0.54 -6.18 -0.35 2.43e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs2243480 1.000 rs1701758 chr7:65470201 T/A cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC cis rs9916302 0.904 rs55660616 chr17:37684990 C/A cg20243544 chr17:37824526 PNMT 0.52 6.58 0.37 2.56e-10 Glomerular filtration rate (creatinine); CESC cis rs9894429 0.752 rs7502883 chr17:79588557 T/C cg18240062 chr17:79603768 NPLOC4 0.89 13.21 0.63 6.03e-31 Eye color traits; CESC cis rs8068544 0.818 rs79892925 chr17:40171819 A/G cg26502583 chr17:39992600 KLHL10;NT5C3L -0.77 -6.07 -0.35 4.42e-9 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg17366294 chr4:99064904 C4orf37 0.61 8.5 0.46 1.36e-15 Colonoscopy-negative controls vs population controls; CESC cis rs11599315 0.757 rs11250392 chr10:1342543 T/C cg09624528 chr10:1369823 ADARB2 0.43 5.94 0.34 8.79e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2228479 0.850 rs62056066 chr16:89906563 G/A cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs10779751 0.922 rs4845985 chr1:11288618 G/A cg08854313 chr1:11322531 MTOR 0.83 11.83 0.59 3.29e-26 Body mass index; CESC cis rs12474201 1.000 rs12474201 chr2:46921285 C/T cg06386533 chr2:46925753 SOCS5 0.81 11.39 0.57 9.87e-25 Height; CESC cis rs7617773 0.817 rs9853804 chr3:48327729 T/C cg11946769 chr3:48343235 NME6 0.8 10.89 0.56 4.71e-23 Coronary artery disease; CESC trans rs11098499 0.955 rs1511015 chr4:120170473 A/C cg25214090 chr10:38739885 LOC399744 0.63 8.31 0.45 4.87e-15 Corneal astigmatism; CESC cis rs7605827 0.866 rs2276664 chr2:15701002 A/T cg19274914 chr2:15703543 NA 0.3 5.34 0.31 2.03e-7 Educational attainment (years of education); CESC cis rs2228479 0.681 rs7196840 chr16:89959647 A/G cg06558623 chr16:89946397 TCF25 0.6 5.97 0.34 7.77e-9 Skin colour saturation; CESC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg04944784 chr2:26401820 FAM59B -0.88 -10.55 -0.54 5.72e-22 Gut microbiome composition (summer); CESC cis rs1322639 1.000 rs9689079 chr6:169587148 A/G cg04662567 chr6:169592167 NA 0.52 6.86 0.39 4.87e-11 Pulse pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06031423 chr22:24059642 LOC91316 -0.42 -6.5 -0.37 3.91e-10 Gambling; CESC cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg25019033 chr10:957182 NA -0.57 -6.14 -0.35 3.01e-9 Eosinophil percentage of granulocytes; CESC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg06600287 chr1:53387719 ECHDC2 -0.3 -5.34 -0.31 1.98e-7 Monocyte count; CESC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg02725872 chr8:58115012 NA -0.41 -5.73 -0.33 2.68e-8 Developmental language disorder (linguistic errors); CESC cis rs7786808 0.615 rs1563066 chr7:158194935 A/C cg01191920 chr7:158217561 PTPRN2 -0.33 -5.47 -0.32 1.03e-7 Obesity-related traits; CESC cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg02487422 chr3:49467188 NICN1 0.4 5.15 0.3 5.11e-7 Parkinson's disease; CESC cis rs447735 0.587 rs258335 chr16:89720944 G/A cg04240660 chr16:89714849 CHMP1A -0.37 -5.23 -0.31 3.46e-7 Hemoglobin concentration; CESC cis rs2806561 0.734 rs2235548 chr1:23394062 G/A cg12483005 chr1:23474871 LUZP1 0.34 5.22 0.31 3.61e-7 Height; CESC trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg15704280 chr7:45808275 SEPT13 -0.82 -13.13 -0.63 1.12e-30 Coronary artery disease; CESC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg09781414 chr16:715207 WDR90 -0.35 -5.29 -0.31 2.62e-7 Height; CESC cis rs8050907 0.744 rs10438587 chr16:4522160 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg12463550 chr7:65579703 CRCP 0.56 7.22 0.41 5.46e-12 Aortic root size; CESC trans rs1994135 0.692 rs7297538 chr12:33693438 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.34 0.41 2.7e-12 Resting heart rate; CESC cis rs11252926 0.603 rs11252670 chr10:529152 A/G cg18196295 chr10:418757 DIP2C -0.51 -6.87 -0.39 4.57e-11 Psychosis in Alzheimer's disease; CESC cis rs7649275 0.655 rs898420 chr3:53783784 T/G cg21503701 chr3:53781065 CACNA1D -0.39 -5.19 -0.3 4.28e-7 Trans fatty acid levels; CESC cis rs1670533 1.000 rs1670534 chr4:1087265 T/C cg04106633 chr4:1044584 NA 0.4 5.08 0.3 6.98e-7 Recombination rate (females); CESC cis rs11122272 0.735 rs2749711 chr1:231537543 G/A cg06096015 chr1:231504339 EGLN1 0.42 6.07 0.35 4.33e-9 Hemoglobin concentration; CESC cis rs4566357 0.557 rs2272201 chr2:227912551 T/A cg11843606 chr2:227700838 RHBDD1 -0.5 -6.83 -0.39 5.8e-11 Coronary artery disease; CESC cis rs3733585 0.699 rs7663097 chr4:9966791 T/C cg00071950 chr4:10020882 SLC2A9 -0.7 -11.44 -0.57 6.82e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4803468 1.000 rs10422956 chr19:41901261 C/T cg09537434 chr19:41945824 ATP5SL -1.06 -18.97 -0.76 2.87e-51 Height; CESC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -6.81 -0.39 6.64e-11 Personality dimensions; CESC cis rs113835537 0.529 rs2305532 chr11:66298594 C/T cg24851651 chr11:66362959 CCS 0.5 5.96 0.34 8.04e-9 Airway imaging phenotypes; CESC cis rs7927592 0.913 rs6591340 chr11:68297636 A/G cg16797656 chr11:68205561 LRP5 0.38 5.08 0.3 7.27e-7 Total body bone mineral density; CESC cis rs72627123 0.500 rs68148895 chr14:74529523 C/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.53 5.94 0.34 9.08e-9 Morning vs. evening chronotype; CESC cis rs72781680 0.898 rs72786288 chr2:24075416 G/T cg20701182 chr2:24300061 SF3B14 0.62 5.6 0.33 5.24e-8 Lymphocyte counts; CESC cis rs12422267 0.536 rs12303484 chr12:132609558 G/A cg05134918 chr12:132603531 EP400NL -0.45 -5.22 -0.31 3.69e-7 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg25072359 chr17:41440525 NA 0.5 6.5 0.37 3.94e-10 Menopause (age at onset); CESC cis rs752092 1.000 rs8033360 chr15:101778710 C/A cg19997662 chr15:101784653 CHSY1 -0.53 -7.05 -0.4 1.54e-11 Corneal structure; CESC cis rs6499255 1.000 rs8045682 chr16:69786092 C/A cg15192750 chr16:69999425 NA 0.44 5.32 0.31 2.26e-7 IgE levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15673731 chr1:156084691 LMNA 0.64 7.34 0.41 2.57e-12 Gut microbiome composition (summer); CESC cis rs8072100 0.713 rs57427906 chr17:45494014 G/A cg08085267 chr17:45401833 C17orf57 -0.52 -6.6 -0.38 2.28e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs5758659 0.967 rs5758670 chr22:42636687 T/C cg04733989 chr22:42467013 NAGA 0.41 5.65 0.33 4.06e-8 Cognitive function; CESC cis rs929354 1.000 rs1182389 chr7:157038803 C/T cg05182265 chr7:156933206 UBE3C -0.4 -5.49 -0.32 9.53e-8 Body mass index; CESC cis rs916888 0.821 rs199504 chr17:44861003 C/T cg15921436 chr17:44337874 NA -0.69 -7.63 -0.42 4.11e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg11764359 chr7:65958608 NA 0.72 9.69 0.51 3.24e-19 Aortic root size; CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg15112475 chr7:1198522 ZFAND2A -0.43 -6.79 -0.38 7.32e-11 Longevity;Endometriosis; CESC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg23048001 chr7:2026167 MAD1L1 -0.47 -6.27 -0.36 1.44e-9 Bipolar disorder and schizophrenia; CESC trans rs9858542 0.953 rs7648841 chr3:49416825 G/A cg21659725 chr3:3221576 CRBN -0.55 -6.53 -0.37 3.34e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs12791968 0.765 rs11038250 chr11:45009114 A/G cg11846598 chr11:44996168 LOC221122 -0.49 -6.06 -0.35 4.53e-9 Inhibitory control; CESC cis rs72781680 1.000 rs72788278 chr2:24095285 A/C cg08917208 chr2:24149416 ATAD2B 0.91 8.38 0.46 3.17e-15 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16262357 chr19:36266374 SNX26 0.69 8.13 0.45 1.63e-14 Gut microbiome composition (summer); CESC cis rs72627123 0.867 rs3815331 chr14:74482948 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.81 5.36 0.31 1.78e-7 Morning vs. evening chronotype; CESC cis rs3749237 0.595 rs3870338 chr3:49557051 A/G cg03060546 chr3:49711283 APEH 0.75 11.67 0.58 1.15e-25 Resting heart rate; CESC cis rs4727027 0.933 rs13225884 chr7:148857795 A/G cg23158103 chr7:148848205 ZNF398 -0.44 -7.15 -0.4 8.28e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg02018176 chr4:1364513 KIAA1530 0.6 7.5 0.42 9.39e-13 Longevity; CESC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg05564831 chr3:52568323 NT5DC2 0.47 7.33 0.41 2.79e-12 Electroencephalogram traits; CESC cis rs7824557 0.592 rs2572371 chr8:11223793 G/T cg21775007 chr8:11205619 TDH 0.48 7.07 0.4 1.35e-11 Retinal vascular caliber; CESC cis rs2733201 1.000 rs1426658 chr15:44338919 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.67 -5.5 -0.32 8.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs7794273 0.821 rs7810384 chr7:18844771 C/T cg13420273 chr7:18810212 HDAC9 0.4 5.64 0.33 4.32e-8 Night sleep phenotypes; CESC cis rs2011503 1.000 rs2905422 chr19:19460703 A/G cg11584989 chr19:19387371 SF4 -0.65 -7.28 -0.41 3.9e-12 Bipolar disorder; CESC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg08109568 chr15:31115862 NA -0.71 -9.49 -0.5 1.42e-18 Huntington's disease progression; CESC cis rs7772486 0.846 rs2144478 chr6:146381445 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.66 0.38 1.55e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg04369109 chr6:150039330 LATS1 -0.43 -6.08 -0.35 4.24e-9 Lung cancer; CESC cis rs977987 0.835 rs11641532 chr16:75329480 T/C cg03315344 chr16:75512273 CHST6 0.38 5.57 0.32 6.31e-8 Dupuytren's disease; CESC cis rs734999 0.549 rs2764840 chr1:2529437 C/T cg18854424 chr1:2615690 NA -0.27 -5.46 -0.32 1.12e-7 Ulcerative colitis; CESC cis rs11608355 0.521 rs6606709 chr12:109846714 A/C cg19025524 chr12:109796872 NA -0.52 -7.14 -0.4 9e-12 Neuroticism; CESC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg03188948 chr7:1209495 NA 0.61 6.09 0.35 3.91e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs875971 1.000 rs7789554 chr7:65946038 A/G cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs8070740 0.838 rs1050461 chr17:5336210 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.58 6.7 0.38 1.27e-10 Menopause (age at onset); CESC cis rs11190604 1.000 rs11190540 chr10:102202629 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs1642645 0.793 rs7546128 chr1:42473659 C/A cg16685388 chr1:42384056 HIVEP3 0.38 5.68 0.33 3.57e-8 Left ventricular obstructive tract defect (maternal effect); CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg25458520 chr6:36099195 MAPK13 0.43 6.1 0.35 3.77e-9 Weight; CESC cis rs559928 0.569 rs7103915 chr11:63944370 A/G cg18225595 chr11:63971243 STIP1 -0.62 -5.26 -0.31 3.01e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg21724239 chr8:58056113 NA 0.58 5.97 0.34 7.54e-9 Developmental language disorder (linguistic errors); CESC cis rs10791097 0.720 rs6590515 chr11:130733365 A/G cg12179176 chr11:130786555 SNX19 -0.65 -9.98 -0.52 3.91e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs258892 0.947 rs9885319 chr5:72179404 T/G cg21869765 chr5:72125136 TNPO1 0.45 5.65 0.33 4.2e-8 Small cell lung carcinoma; CESC cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg03467027 chr4:99064603 C4orf37 0.48 5.95 0.34 8.67e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1005277 0.505 rs1208689 chr10:38097775 C/G cg00409905 chr10:38381863 ZNF37A -0.55 -7.61 -0.42 4.93e-13 Extrinsic epigenetic age acceleration; CESC cis rs116095464 0.558 rs11959126 chr5:283880 T/G cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.41 0.32 1.38e-7 Breast cancer; CESC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg18337363 chr3:52569053 NT5DC2 0.29 5.29 0.31 2.56e-7 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13599271 chr3:58291905 RPP14 0.6 6.63 0.38 1.83e-10 Gut microbiome composition (summer); CESC cis rs6060717 0.610 rs2244883 chr20:34620896 A/G cg17201900 chr20:34330562 RBM39 0.47 5.26 0.31 2.97e-7 Hip circumference adjusted for BMI; CESC cis rs1348850 0.632 rs13009207 chr2:178501632 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.49 0.42 1.06e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1577917 0.739 rs2758846 chr6:86349570 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.53 -7.11 -0.4 1.05e-11 Response to antipsychotic treatment; CESC cis rs6570726 0.935 rs408723 chr6:145838535 A/G cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01091156 chr16:87991122 BANP 0.45 6.18 0.35 2.41e-9 Fibrinogen levels; CESC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.38 0.31 1.65e-7 Menopause (age at onset); CESC cis rs2197308 0.565 rs4123923 chr12:37857684 T/C cg26384229 chr12:38710491 ALG10B 0.74 10.95 0.56 2.84e-23 Morning vs. evening chronotype; CESC cis rs28374715 0.662 rs691907 chr15:41474657 C/G cg18705301 chr15:41695430 NDUFAF1 0.74 9.83 0.52 1.25e-19 Ulcerative colitis; CESC cis rs5769765 1.000 rs2092982 chr22:50282204 C/A cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs2777491 1.000 rs316610 chr15:41752852 C/T cg20272979 chr15:41787780 ITPKA 0.44 6.5 0.37 4.02e-10 Ulcerative colitis; CESC cis rs9790314 0.586 rs16832279 chr3:161120483 C/T cg03342759 chr3:160939853 NMD3 -0.44 -5.71 -0.33 2.99e-8 Morning vs. evening chronotype; CESC cis rs12143943 0.934 rs1870551 chr1:204581014 A/G cg20240347 chr1:204465584 NA -0.26 -5.08 -0.3 7.07e-7 Cognitive performance; CESC cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg11812906 chr14:75593930 NEK9 0.85 14.67 0.67 4.43e-36 Height; CESC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg26818010 chr10:134567672 INPP5A -0.91 -11.08 -0.56 1.05e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6445797 0.890 rs13073181 chr3:56572454 C/G cg13792233 chr3:56591045 CCDC66 0.39 5.4 0.32 1.45e-7 Gastritis; CESC cis rs761746 0.960 rs738656 chr22:31935347 G/A cg25791279 chr22:32026902 PISD -0.52 -5.9 -0.34 1.09e-8 Intelligence; CESC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg12311346 chr5:56204834 C5orf35 -0.72 -8.88 -0.48 1.01e-16 Initial pursuit acceleration; CESC cis rs12136530 0.625 rs10917447 chr1:19749743 T/C cg01832549 chr1:19774989 CAPZB -0.5 -6.92 -0.39 3.42e-11 Lead levels in blood; CESC cis rs4862750 0.872 rs13101380 chr4:187894744 G/A cg03647317 chr4:187891568 NA -0.46 -7.03 -0.4 1.79e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1797081 0.561 rs2603795 chr10:16860256 A/G cg23933602 chr10:16859644 RSU1 0.73 9.45 0.5 1.81e-18 Platelet distribution width; CESC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg23758822 chr17:41437982 NA 1.0 15.66 0.69 1.44e-39 Menopause (age at onset); CESC cis rs7666738 0.830 rs62318504 chr4:98935558 T/G cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12090654 chr8:6424636 MCPH1 0.49 6.44 0.37 5.44e-10 Fibrinogen levels; CESC cis rs6752107 0.967 rs36001488 chr2:234185267 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.39 5.91 0.34 1.07e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs1580019 0.562 rs4720064 chr7:32559638 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.73 0.38 1.05e-10 Cognitive ability; CESC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg08736216 chr1:53307985 ZYG11A 0.31 5.41 0.32 1.39e-7 Monocyte count; CESC trans rs78049276 0.688 rs56024659 chr4:148378604 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.69 -8.02 -0.44 3.47e-14 Pulse pressure; CESC cis rs1790761 0.692 rs611663 chr11:67312221 C/T cg24690094 chr11:67383802 NA 0.35 5.86 0.34 1.4e-8 Mean corpuscular volume; CESC cis rs11608355 0.545 rs6606724 chr12:109905179 T/C cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg23172400 chr8:95962367 TP53INP1 -0.43 -8.89 -0.48 9.58e-17 Type 2 diabetes; CESC cis rs873946 0.586 rs12783078 chr10:134569706 C/T cg27297192 chr10:134578999 INPP5A 0.4 5.15 0.3 5.16e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4803468 1.000 rs2241706 chr19:41912807 A/G cg14132834 chr19:41945861 ATP5SL -0.67 -8.31 -0.45 5.08e-15 Height; CESC cis rs6540559 0.673 rs7511996 chr1:210018473 C/A cg25204440 chr1:209979598 IRF6 0.53 5.27 0.31 2.8e-7 Cleft lip with or without cleft palate; CESC cis rs1538970 0.924 rs11211111 chr1:45908782 C/T cg03146154 chr1:46216737 IPP 0.46 5.34 0.31 1.97e-7 Platelet count; CESC cis rs7084402 0.967 rs1658458 chr10:60301382 T/C cg07615347 chr10:60278583 BICC1 0.6 9.46 0.5 1.77e-18 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24100506 chr3:44903551 TMEM42 0.68 7.85 0.43 1.05e-13 Gut microbiome composition (summer); CESC cis rs78889164 0.876 rs1061338 chr19:33878198 A/G cg02272751 chr19:33882848 PEPD -0.53 -7.75 -0.43 1.91e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs6912958 0.781 rs9450732 chr6:88249826 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.56 -0.37 2.75e-10 Monocyte percentage of white cells; CESC cis rs2629540 0.737 rs10901821 chr10:126480556 T/C cg08799069 chr10:126477246 METTL10 -0.56 -7.98 -0.44 4.55e-14 Cocaine dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09134154 chr10:60094858 UBE2D1 0.6 6.89 0.39 4.05e-11 Gut microbiome composition (summer); CESC cis rs5758659 1.000 rs134902 chr22:42683997 C/T cg04733989 chr22:42467013 NAGA 0.41 5.84 0.34 1.49e-8 Cognitive function; CESC cis rs1044826 0.642 rs4683464 chr3:139196961 C/T cg15131784 chr3:139108705 COPB2 0.41 5.15 0.3 5.16e-7 Obesity-related traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07738014 chr19:3627036 C19orf29 -0.43 -6.54 -0.37 3.16e-10 Gambling; CESC cis rs6582630 0.555 rs11182148 chr12:38464883 A/C cg26384229 chr12:38710491 ALG10B 0.66 10.01 0.52 3.14e-20 Drug-induced liver injury (flucloxacillin); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16491506 chr14:61189969 SIX4 -0.53 -6.86 -0.39 4.92e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21659725 chr3:3221576 CRBN -0.83 -13.7 -0.64 1.18e-32 Intelligence (multi-trait analysis); CESC cis rs763121 0.853 rs1043441 chr22:39130964 C/T cg06544989 chr22:39130855 UNC84B 0.46 8.07 0.44 2.39e-14 Menopause (age at onset); CESC cis rs854765 0.583 rs7214536 chr17:17852446 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02283353 chr19:622406 POLRMT 0.45 6.02 0.35 5.66e-9 Fibrinogen levels; CESC cis rs651907 0.557 rs11917682 chr3:101355427 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 5.84 0.34 1.56e-8 Colorectal cancer; CESC cis rs73206853 0.563 rs73194040 chr12:111181106 C/T cg12870014 chr12:110450643 ANKRD13A 0.67 5.25 0.31 3.16e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.65 8.64 0.47 5.48e-16 Menopause (age at onset); CESC cis rs4969178 0.965 rs8072632 chr17:76397830 T/C cg05887092 chr17:76393375 PGS1 0.58 9.21 0.49 1.01e-17 HDL cholesterol levels; CESC cis rs9487051 0.676 rs6568567 chr6:109596993 A/G cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs67478160 0.619 rs28698555 chr14:104316486 C/A cg01849466 chr14:104193079 ZFYVE21 0.5 6.92 0.39 3.35e-11 Schizophrenia; CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.48 6.27 0.36 1.47e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg11764359 chr7:65958608 NA -0.94 -13.99 -0.65 1.14e-33 Aortic root size; CESC cis rs9815354 1.000 rs9818169 chr3:41860599 A/G cg03022575 chr3:42003672 ULK4 0.45 5.06 0.3 7.71e-7 Pulse pressure;Diastolic blood pressure; CESC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg22968622 chr17:43663579 NA -0.79 -10.84 -0.55 6.65e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11718455 0.653 rs28533958 chr3:43974179 C/A cg08738300 chr3:44038990 NA 0.47 6.25 0.36 1.66e-9 Coronary artery disease; CESC cis rs4566357 0.576 rs10187255 chr2:227913442 T/A cg11843606 chr2:227700838 RHBDD1 -0.5 -6.82 -0.39 6.08e-11 Coronary artery disease; CESC cis rs2742234 0.541 rs12416428 chr10:43708998 G/A cg15436174 chr10:43711423 RASGEF1A 0.47 5.53 0.32 7.48e-8 Hirschsprung disease; CESC cis rs6460942 0.597 rs7778131 chr7:12543233 T/G cg06484146 chr7:12443880 VWDE -0.72 -7.45 -0.42 1.35e-12 Coronary artery disease; CESC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg18876405 chr7:65276391 NA 0.7 9.79 0.52 1.64e-19 Aortic root size; CESC cis rs4805272 0.539 rs7256211 chr19:29333063 C/G cg12756686 chr19:29218302 NA 0.4 5.3 0.31 2.45e-7 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs10779751 1.000 rs742824 chr1:11274022 G/A cg08854313 chr1:11322531 MTOR 0.91 14.23 0.66 1.61e-34 Body mass index; CESC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg13206674 chr6:150067644 NUP43 0.46 6.66 0.38 1.61e-10 Lung cancer; CESC trans rs1814175 0.646 rs1722010 chr11:49897958 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.51e-9 Height; CESC trans rs17685 0.753 rs10262501 chr7:75668172 G/A cg19862616 chr7:65841803 NCRNA00174 -0.84 -12.36 -0.6 5.05e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs7044106 0.791 rs10985004 chr9:123484937 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.91 15.2 0.68 6.03e-38 Hip circumference adjusted for BMI; CESC cis rs9649465 0.846 rs13044 chr7:123322716 T/A cg04330084 chr7:123175371 IQUB -0.38 -5.15 -0.3 5.02e-7 Migraine; CESC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.49 6.21 0.36 2.03e-9 Prudent dietary pattern; CESC cis rs3820068 0.603 rs41270279 chr1:15988878 A/G cg16988262 chr1:15930761 NA 0.34 5.64 0.33 4.34e-8 Systolic blood pressure; CESC cis rs67311347 0.956 rs4974029 chr3:40521318 C/G cg01475735 chr3:40494733 NA -0.41 -5.23 -0.31 3.52e-7 Renal cell carcinoma; CESC cis rs10504229 1.000 rs58608483 chr8:58195269 T/G cg24829409 chr8:58192753 C8orf71 -0.63 -8.53 -0.46 1.1e-15 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg00129232 chr17:37814104 STARD3 0.59 7.82 0.43 1.22e-13 Glomerular filtration rate (creatinine); CESC cis rs6987853 0.966 rs2974359 chr8:42434194 T/C cg09913449 chr8:42400586 C8orf40 0.39 6.2 0.36 2.12e-9 Mean corpuscular hemoglobin concentration; CESC cis rs1707322 0.964 rs10890358 chr1:46319025 T/A cg05343316 chr1:45956843 TESK2 0.43 5.28 0.31 2.68e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg21918786 chr6:109611834 NA -0.39 -6.04 -0.35 5.08e-9 Reticulocyte fraction of red cells; CESC cis rs10883723 0.810 rs7094366 chr10:104274730 C/G ch.10.2196322F chr10:104248062 ACTR1A 0.44 5.15 0.3 5.03e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs688020 1.000 rs688020 chr7:4228553 C/T cg02004499 chr7:4244250 SDK1 0.42 6.01 0.35 6.14e-9 Liver fibrosis in pediatric non-alcoholic fatty acid liver disease; CESC cis rs11997175 0.583 rs56045827 chr8:33787015 G/A ch.8.33884649F chr8:33765107 NA 0.45 5.73 0.33 2.78e-8 Body mass index; CESC cis rs2573652 1.000 rs2581359 chr15:100513707 A/G cg00587665 chr15:100533223 ADAMTS17 -0.37 -5.9 -0.34 1.1e-8 Height; CESC cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg10523679 chr1:76189770 ACADM 0.68 6.63 0.38 1.86e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4654899 0.606 rs13376428 chr1:21120027 T/C cg05370193 chr1:21551575 ECE1 0.35 5.22 0.31 3.54e-7 Superior frontal gyrus grey matter volume; CESC trans rs9929218 0.906 rs33965787 chr16:68828173 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.01 -0.44 3.55e-14 Colorectal cancer; CESC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.47 0.32 1.06e-7 Personality dimensions; CESC cis rs17253792 0.822 rs75999534 chr14:56036413 A/T cg24579896 chr14:56047964 C14orf33;KTN1 0.83 5.51 0.32 8.68e-8 Putamen volume; CESC cis rs950169 0.887 rs12903946 chr15:84954430 T/C cg17507749 chr15:85114479 UBE2QP1 0.59 6.54 0.37 3.11e-10 Schizophrenia; CESC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg22903657 chr4:1355424 KIAA1530 -0.4 -5.7 -0.33 3.2e-8 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25382472 chr1:47779932 STIL 0.6 7.01 0.4 1.99e-11 Gut microbiome composition (summer); CESC cis rs3815700 1.000 rs8109768 chr19:33095463 A/G cg24916020 chr19:33096688 ANKRD27 0.59 5.75 0.33 2.5e-8 Eosinophilic esophagitis; CESC trans rs7335046 1.000 rs9517667 chr13:99915135 G/A cg08418111 chr11:18433745 LDHC 0.6 6.01 0.35 6.07e-9 Basal cell carcinoma; CESC cis rs9902453 0.904 rs9900112 chr17:28282910 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 9.34 0.5 4.06e-18 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13909320 chr9:125026858 MRRF;RBM18 0.63 7.51 0.42 8.96e-13 Gut microbiome composition (summer); CESC cis rs9303401 0.614 rs56284918 chr17:57178838 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.92 11.49 0.58 4.47e-25 Cognitive test performance; CESC cis rs2073300 0.609 rs56094936 chr20:23401586 G/A cg16736954 chr20:23401023 NAPB 0.77 5.57 0.32 6.37e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7605827 0.857 rs9973946 chr2:15631022 C/T cg19274914 chr2:15703543 NA 0.35 6.12 0.35 3.27e-9 Educational attainment (years of education); CESC cis rs477692 1.000 rs565974 chr10:131423274 C/T cg05714579 chr10:131428358 MGMT 0.48 6.49 0.37 4.29e-10 Response to temozolomide; CESC cis rs854765 0.655 rs4470201 chr17:17844870 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.28 0.41 3.7e-12 Total body bone mineral density; CESC cis rs4812048 1.000 rs4812048 chr20:57587771 C/T cg14073986 chr20:57617431 SLMO2 0.6 5.15 0.3 5.11e-7 Mean platelet volume; CESC cis rs7945705 0.967 rs10769970 chr11:8917937 A/G cg12365402 chr11:9010492 NRIP3 0.38 5.86 0.34 1.39e-8 Hemoglobin concentration; CESC cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 2e-28 Colonoscopy-negative controls vs population controls; CESC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg24503407 chr1:205819492 PM20D1 0.81 13.75 0.65 7.52e-33 Menarche (age at onset); CESC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg10691866 chr7:65817282 TPST1 0.31 5.06 0.3 7.76e-7 Aortic root size; CESC cis rs6568686 0.627 rs174381 chr6:111913479 C/T cg22127309 chr6:111907043 TRAF3IP2 0.54 5.15 0.3 5.14e-7 Depressive and manic episodes in bipolar disorder;Depressive episodes in bipolar disorder; CESC cis rs9902453 1.000 rs57411618 chr17:28273052 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 8.28 0.45 6.2e-15 Coffee consumption (cups per day); CESC cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg09658497 chr7:2847517 GNA12 -0.37 -5.49 -0.32 9.32e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21611868 chr3:135969116 PCCB 0.62 7.07 0.4 1.41e-11 Gut microbiome composition (summer); CESC cis rs11997175 0.546 rs11778519 chr8:33615873 G/A ch.8.33884649F chr8:33765107 NA 0.57 7.35 0.41 2.5e-12 Body mass index; CESC cis rs1008375 0.932 rs6844593 chr4:17659039 T/C cg02297831 chr4:17616191 MED28 0.63 8.03 0.44 3.3e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg12463550 chr7:65579703 CRCP 0.57 7.2 0.4 6.12e-12 Aortic root size; CESC cis rs6011002 0.935 rs75123278 chr20:62312531 G/A cg15212369 chr20:62274085 STMN3 -0.59 -5.11 -0.3 6.12e-7 Dental caries; CESC cis rs9911578 1.000 rs9901114 chr17:56575208 G/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -5.42 -0.32 1.33e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13555728 chr17:77071390 ENGASE 0.56 6.5 0.37 4.07e-10 Gut microbiome composition (summer); CESC cis rs4555082 0.830 rs2816648 chr14:105708289 C/T cg06808227 chr14:105710500 BRF1 -0.55 -6.16 -0.35 2.71e-9 Mean platelet volume;Platelet distribution width; CESC cis rs9814567 1.000 rs1917130 chr3:134313773 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.46 6.24 0.36 1.76e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg06481639 chr22:41940642 POLR3H 0.57 5.83 0.34 1.62e-8 Vitiligo; CESC cis rs7208859 0.623 rs9911997 chr17:29124648 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg00129232 chr17:37814104 STARD3 0.58 7.66 0.43 3.48e-13 Glomerular filtration rate (creatinine); CESC cis rs113835537 0.529 rs17147644 chr11:66256660 C/T cg22134325 chr11:66188745 NPAS4 0.36 5.54 0.32 7.37e-8 Airway imaging phenotypes; CESC cis rs875971 0.651 rs313829 chr7:65552497 A/G cg06263672 chr7:65235340 NA -0.45 -5.16 -0.3 4.93e-7 Aortic root size; CESC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.47 0.37 4.74e-10 Bipolar disorder; CESC cis rs992157 0.560 rs6738394 chr2:219110625 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.57 -7.29 -0.41 3.47e-12 Colorectal cancer; CESC cis rs909002 0.886 rs10798880 chr1:32097088 G/T cg13919466 chr1:32135498 COL16A1 -0.48 -8.3 -0.45 5.4e-15 Intelligence (multi-trait analysis); CESC cis rs4888262 0.545 rs4888270 chr16:74698576 A/G cg01733217 chr16:74700730 RFWD3 0.91 12.9 0.62 7.31e-30 Testicular germ cell tumor; CESC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg14393609 chr7:65229607 NA 0.47 6.33 0.36 1.05e-9 Aortic root size; CESC cis rs7216064 1.000 rs62084210 chr17:65828710 A/G cg12091567 chr17:66097778 LOC651250 -0.87 -8.69 -0.47 3.74e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs798554 0.704 rs2527684 chr7:2825922 G/T cg09658497 chr7:2847517 GNA12 -0.35 -5.31 -0.31 2.37e-7 Height; CESC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg10494973 chr17:80897199 TBCD -0.5 -6.28 -0.36 1.39e-9 Breast cancer; CESC cis rs36229146 1 rs36229146 chr7:22784486 TTATATATAAATATATATATATATATA/T cg26061582 chr7:22766209 IL6 0.51 5.44 0.32 1.19e-7 Eosinophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CESC cis rs6963495 0.818 rs73190156 chr7:105153567 C/T cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs2228479 0.850 rs11639906 chr16:89798183 T/C cg06558623 chr16:89946397 TCF25 1.03 7.52 0.42 8.67e-13 Skin colour saturation; CESC cis rs7216064 1.000 rs6504542 chr17:65836642 T/C cg07042672 chr17:66097459 LOC651250 -0.57 -6.69 -0.38 1.32e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10169971 chr6:83902988 RWDD2A;PGM3 -0.55 -7.31 -0.41 3.13e-12 Fibrinogen levels; CESC cis rs4253772 0.550 rs6008598 chr22:46704243 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.67 6.47 0.37 4.82e-10 LDL cholesterol;Cholesterol, total; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24712243 chr11:61310195 SYT7 0.48 6.34 0.36 9.62e-10 Fibrinogen levels; CESC cis rs735396 1.000 rs1169306 chr12:121438311 C/T cg02403541 chr12:121454288 C12orf43 0.63 9.0 0.48 4.61e-17 N-glycan levels; CESC cis rs9354308 0.901 rs12197136 chr6:66590953 T/C cg07460842 chr6:66804631 NA 0.65 7.46 0.42 1.26e-12 Metabolite levels; CESC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.86 0.59 2.65e-26 Alzheimer's disease; CESC cis rs4594175 0.926 rs10135534 chr14:51617970 C/A cg23942311 chr14:51606299 NA 0.39 5.95 0.34 8.44e-9 Cancer; CESC cis rs763121 0.853 rs6001175 chr22:39018334 T/C cg21395723 chr22:39101663 GTPBP1 0.5 6.75 0.38 9.48e-11 Menopause (age at onset); CESC cis rs11252926 0.537 rs4554800 chr10:458477 G/T cg16386425 chr10:429943 DIP2C 0.55 7.14 0.4 8.79e-12 Psychosis in Alzheimer's disease; CESC cis rs911555 0.755 rs34411783 chr14:103900639 G/A cg24130564 chr14:104152367 KLC1 0.5 6.68 0.38 1.4e-10 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21146272 chr6:42858716 C6orf226 0.45 6.18 0.35 2.37e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg06634786 chr22:41940651 POLR3H -0.66 -6.56 -0.37 2.76e-10 Vitiligo; CESC cis rs2991971 0.901 rs11211122 chr1:45954650 C/T cg24296786 chr1:45957014 TESK2 0.66 9.2 0.49 1.09e-17 High light scatter reticulocyte count; CESC cis rs11893307 0.507 rs1465303 chr2:191585440 A/C cg10560079 chr2:191398806 TMEM194B -0.45 -5.59 -0.32 5.55e-8 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14967814 chr3:179041370 ZNF639 0.58 6.91 0.39 3.52e-11 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.06e-7 Aortic root size; CESC cis rs796364 0.616 rs2030653 chr2:200677625 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.55 5.1 0.3 6.6e-7 Schizophrenia; CESC cis rs977987 0.864 rs37592 chr16:75496791 G/C cg03315344 chr16:75512273 CHST6 -0.46 -6.48 -0.37 4.48e-10 Dupuytren's disease; CESC cis rs2070488 0.775 rs1073505 chr3:38566722 T/C cg24069376 chr3:38537580 EXOG -0.32 -5.54 -0.32 7.32e-8 Electrocardiographic conduction measures; CESC cis rs7116495 0.609 rs595062 chr11:71809635 C/T cg26138937 chr11:71823887 C11orf51 1.29 7.98 0.44 4.34e-14 Severe influenza A (H1N1) infection; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09513169 chr5:178287767 ZNF354B 0.41 6.08 0.35 4.13e-9 Gambling; CESC cis rs10493773 0.894 rs12067749 chr1:86197922 T/C cg17807903 chr1:86174739 ZNHIT6 -0.42 -5.58 -0.32 5.98e-8 Urate levels in overweight individuals; CESC cis rs916888 0.697 rs199516 chr17:44856485 C/T cg14517863 chr17:44321492 NA -0.4 -5.25 -0.31 3.08e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11997175 1.000 rs6468203 chr8:33749572 T/A ch.8.33884649F chr8:33765107 NA 0.64 8.22 0.45 9.09e-15 Body mass index; CESC cis rs9611565 0.765 rs132909 chr22:41802031 G/A cg03806693 chr22:41940476 POLR3H 1.04 12.37 0.61 4.76e-28 Vitiligo; CESC cis rs2742234 0.541 rs2742235 chr10:43616325 A/G cg07801480 chr10:43725741 RASGEF1A 0.4 5.26 0.31 3.01e-7 Hirschsprung disease; CESC cis rs6598955 0.671 rs12116908 chr1:26587918 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27612058 chr17:30228670 UTP6 0.59 6.56 0.37 2.82e-10 Gut microbiome composition (summer); CESC cis rs9811920 0.928 rs9865713 chr3:99870299 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.43 7.02 0.4 1.81e-11 Axial length; CESC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg16405210 chr4:1374714 KIAA1530 -0.41 -5.36 -0.31 1.85e-7 Obesity-related traits; CESC cis rs9611565 0.649 rs79005 chr22:41835544 G/A cg03806693 chr22:41940476 POLR3H 1.13 15.27 0.68 3.52e-38 Vitiligo; CESC cis rs8049040 0.524 rs891125 chr16:71431621 C/T cg08717414 chr16:71523259 ZNF19 -0.63 -6.94 -0.39 3.06e-11 Blood protein levels; CESC cis rs11718455 0.767 rs6785433 chr3:43964265 A/G cg08738300 chr3:44038990 NA 0.44 5.82 0.34 1.65e-8 Coronary artery disease; CESC cis rs796364 0.806 rs1106400 chr2:201004089 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.64 -6.04 -0.35 5.26e-9 Schizophrenia; CESC trans rs10156309 0.732 rs12542711 chr8:63489846 C/T cg01805890 chr16:75271872 BCAR1 -0.65 -6.16 -0.35 2.65e-9 Allergic rhinitis; CESC cis rs858239 0.699 rs955187 chr7:23194605 A/G cg27449745 chr7:23145252 KLHL7 0.4 5.09 0.3 6.92e-7 Cerebrospinal fluid biomarker levels; CESC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 5.16 0.3 4.74e-7 LDL cholesterol;Cholesterol, total; CESC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg11764359 chr7:65958608 NA 0.72 9.69 0.51 3.24e-19 Aortic root size; CESC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg12463550 chr7:65579703 CRCP -0.54 -6.93 -0.39 3.25e-11 Aortic root size; CESC cis rs6024905 0.587 rs1579101 chr20:36966334 C/T cg07053727 chr20:36965646 BPI 0.53 8.63 0.47 5.94e-16 Bipolar disorder and schizophrenia; CESC cis rs3733585 0.699 rs28837683 chr4:9959808 C/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.91 -0.59 1.82e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg13395646 chr4:1353034 KIAA1530 -0.53 -6.63 -0.38 1.83e-10 Obesity-related traits; CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg16145915 chr7:1198662 ZFAND2A -0.78 -13.36 -0.63 1.73e-31 Longevity;Endometriosis; CESC trans rs2727020 0.658 rs7120136 chr11:49384358 A/C cg15704280 chr7:45808275 SEPT13 -0.91 -15.87 -0.7 2.58e-40 Coronary artery disease; CESC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 11.0 0.56 1.98e-23 Platelet count; CESC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.31 -0.31 2.34e-7 Life satisfaction; CESC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg00129232 chr17:37814104 STARD3 -0.54 -7.13 -0.4 9.71e-12 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg17366294 chr4:99064904 C4orf37 0.52 7.03 0.4 1.71e-11 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 0.901 rs12530490 chr7:65691647 G/A cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC cis rs2070677 0.935 rs13376793 chr10:135421344 C/G cg20169779 chr10:135381914 SYCE1 -0.74 -9.88 -0.52 8.58e-20 Gout; CESC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg24531977 chr5:56204891 C5orf35 1.0 13.17 0.63 8.1e-31 Initial pursuit acceleration; CESC cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg02297831 chr4:17616191 MED28 0.61 7.82 0.43 1.23e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6493487 0.512 rs11070825 chr15:51249529 C/A cg02338191 chr15:51200825 AP4E1 0.63 5.86 0.34 1.39e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9796 0.689 rs9888710 chr15:41446153 G/C cg20272979 chr15:41787780 ITPKA 0.34 5.11 0.3 6.31e-7 Menopause (age at onset); CESC cis rs2479106 0.570 rs10986088 chr9:126443959 C/T cg16191174 chr9:126692580 DENND1A 0.4 5.4 0.31 1.5e-7 Polycystic ovary syndrome; CESC cis rs9916302 0.904 rs2338798 chr17:37547269 T/C cg00129232 chr17:37814104 STARD3 0.6 8.02 0.44 3.47e-14 Glomerular filtration rate (creatinine); CESC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg24549020 chr5:56110836 MAP3K1 -0.47 -5.95 -0.34 8.25e-9 Initial pursuit acceleration; CESC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg26304593 chr6:42947056 PEX6 -0.41 -5.16 -0.3 4.8e-7 Alzheimer's disease in APOE e4+ carriers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19134567 chr3:128444816 RAB7A -0.57 -5.99 -0.35 6.68e-9 Gut microbiome composition (summer); CESC cis rs2439831 1.000 rs2439841 chr15:43734749 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.38 0.54 2.15e-21 Lung cancer in ever smokers; CESC cis rs9486719 1.000 rs9486719 chr6:97060124 G/A cg18709589 chr6:96969512 KIAA0776 -0.46 -5.66 -0.33 4e-8 Migraine;Coronary artery disease; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg26736154 chr15:37020592 C15orf41 0.41 6.24 0.36 1.73e-9 Prevalent atrial fibrillation; CESC cis rs2985684 0.948 rs12897941 chr14:50016701 G/C cg02151108 chr14:50098012 C14orf104 -0.38 -5.05 -0.3 8.37e-7 Carotid intima media thickness; CESC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg27165867 chr14:105738592 BRF1 -0.51 -6.03 -0.35 5.55e-9 Mean platelet volume;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03651852 chr6:52285170 EFHC1 0.58 6.28 0.36 1.38e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03655016 chr12:49453990 NA 0.54 6.14 0.35 2.97e-9 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08573313 chr7:94139369 CASD1 0.5 6.19 0.36 2.28e-9 Gut microbiota (bacterial taxa); CESC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.62 0.33 4.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.69 0.47 3.96e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.98 0.34 7.35e-9 Tonsillectomy; CESC trans rs7937682 0.889 rs11213971 chr11:111529829 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.19 0.36 2.22e-9 Primary sclerosing cholangitis; CESC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg17178900 chr1:205818956 PM20D1 0.79 12.8 0.62 1.57e-29 Menarche (age at onset); CESC cis rs12474201 0.822 rs897530 chr2:46948150 C/G cg06386533 chr2:46925753 SOCS5 0.84 11.45 0.58 6.18e-25 Height; CESC cis rs6032067 0.571 rs6017536 chr20:43907369 G/T cg10761708 chr20:43804764 PI3 0.38 5.05 0.3 8.34e-7 Blood protein levels; CESC trans rs2121875 0.667 rs10079810 chr5:44219951 A/G cg07292773 chr6:156718177 NA -0.47 -6.01 -0.35 6.16e-9 Prostate cancer; CESC cis rs6582630 0.555 rs35186318 chr12:38295822 C/T cg26384229 chr12:38710491 ALG10B -0.45 -5.9 -0.34 1.13e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg13628971 chr7:2884303 GNA12 0.59 7.58 0.42 5.65e-13 Height; CESC cis rs8044868 0.541 rs7202268 chr16:72086746 A/G cg01557791 chr16:72042693 DHODH -0.43 -5.83 -0.34 1.61e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs9896933 0.723 rs7224189 chr17:80782227 C/T cg15664640 chr17:80829946 TBCD -0.55 -6.33 -0.36 1.06e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs4450798 0.649 rs4234518 chr3:13785373 C/T cg23332027 chr3:13681764 NA 0.4 5.58 0.32 5.95e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg00409905 chr10:38381863 ZNF37A -0.48 -6.34 -0.36 9.88e-10 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16652648 chr2:197791396 PGAP1 0.56 6.73 0.38 1.02e-10 Gut microbiome composition (summer); CESC cis rs2066819 1.000 rs59295315 chr12:56708576 G/A cg26714650 chr12:56694279 CS -1.48 -9.9 -0.52 7.03e-20 Psoriasis vulgaris; CESC cis rs2243480 1.000 rs78803505 chr7:65382572 A/T cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs2637266 1.000 rs10824431 chr10:78356622 C/A cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg07936489 chr17:37558343 FBXL20 0.78 11.12 0.56 7.9e-24 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06872435 chr12:43031000 NA -0.63 -7.48 -0.42 1.08e-12 Gut microbiome composition (summer); CESC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg23221052 chr5:179740743 GFPT2 -0.55 -7.36 -0.41 2.32e-12 Height; CESC cis rs631288 0.793 rs1822312 chr1:146687250 A/T cg25205988 chr1:146714368 CHD1L -1.18 -6.79 -0.38 7.51e-11 PR interval in Tripanosoma cruzi seropositivity; CESC trans rs7829975 0.774 rs1039915 chr8:8679614 T/C cg21775007 chr8:11205619 TDH 0.41 6.11 0.35 3.58e-9 Mood instability; CESC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg22800045 chr5:56110881 MAP3K1 0.83 9.99 0.52 3.76e-20 Initial pursuit acceleration; CESC cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11249608 0.548 rs7733072 chr5:178456007 A/G cg21905437 chr5:178450457 ZNF879 0.6 8.73 0.47 2.84e-16 Pubertal anthropometrics; CESC trans rs57221529 0.766 rs72703070 chr5:590458 T/C cg25482853 chr8:67687455 SGK3 1.0 10.02 0.52 2.99e-20 Lung disease severity in cystic fibrosis; CESC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg17178900 chr1:205818956 PM20D1 -0.78 -12.65 -0.61 5.15e-29 Menarche (age at onset); CESC cis rs72615157 0.539 rs12673441 chr7:99670328 A/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.42 5.12 0.3 5.94e-7 Lung function (FEV1/FVC); CESC cis rs17739794 0.677 rs17739674 chr8:801584 G/T cg20652464 chr8:752313 NA -0.29 -5.22 -0.31 3.6e-7 Clozapine-induced cytotoxicity; CESC cis rs2262909 0.962 rs408687 chr19:22231123 T/C cg11619707 chr19:22235551 ZNF257 -0.32 -5.26 -0.31 2.94e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs2933343 0.700 rs876754 chr3:128627753 T/C cg24203234 chr3:128598194 ACAD9 0.43 5.82 0.34 1.74e-8 IgG glycosylation; CESC cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg11742103 chr11:62369870 EML3;MTA2 0.65 10.08 0.53 1.98e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6547741 0.775 rs11692692 chr2:27861707 G/A cg27432699 chr2:27873401 GPN1 -0.61 -8.69 -0.47 3.72e-16 Oral cavity cancer; CESC cis rs4803468 1.000 rs10417311 chr19:41902038 G/A cg09537434 chr19:41945824 ATP5SL -1.06 -19.22 -0.76 3.86e-52 Height; CESC cis rs12291225 0.585 rs4517475 chr11:14386145 A/G cg19336497 chr11:14380999 RRAS2 -0.45 -6.62 -0.38 1.98e-10 Sense of smell; CESC cis rs11583043 0.667 rs4617425 chr1:101543205 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.41 0.32 1.42e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs1595825 0.945 rs1518369 chr2:198859183 C/T cg00982548 chr2:198649783 BOLL -0.44 -5.03 -0.3 8.89e-7 Ulcerative colitis; CESC trans rs61931739 0.517 rs11053063 chr12:34181011 C/T cg13010199 chr12:38710504 ALG10B 0.48 5.99 0.35 6.66e-9 Morning vs. evening chronotype; CESC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.05e-8 Lung cancer; CESC cis rs34779708 0.931 rs17591135 chr10:35465190 T/A cg04310649 chr10:35416472 CREM -0.52 -6.34 -0.36 9.84e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs56235845 0.694 rs11738681 chr5:176761535 A/G cg17509989 chr5:176798049 RGS14 0.49 6.2 0.36 2.16e-9 Hemoglobin concentration;Hematocrit; CESC cis rs4843747 0.671 rs72818577 chr16:88111181 G/A cg03395651 chr16:88107091 BANP 0.45 5.21 0.3 3.84e-7 Menopause (age at onset); CESC cis rs9828933 0.938 rs2578011 chr3:64004819 C/T cg16258503 chr3:63850278 ATXN7;THOC7 -0.61 -6.2 -0.36 2.15e-9 Type 2 diabetes; CESC cis rs854765 0.565 rs854768 chr17:18018806 T/C cg04398451 chr17:18023971 MYO15A -0.77 -11.43 -0.57 7.2e-25 Total body bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16008945 chr10:14996031 DCLRE1C -0.45 -6.48 -0.37 4.38e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2294693 0.947 rs736793 chr6:40997919 A/T cg14418226 chr6:40996092 UNC5CL 0.53 6.66 0.38 1.59e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs7520050 0.807 rs6429576 chr1:46216575 T/C cg03146154 chr1:46216737 IPP 0.51 6.79 0.39 7.23e-11 Red blood cell count;Reticulocyte count; CESC cis rs2180341 0.960 rs9375503 chr6:127677071 T/C cg27446573 chr6:127587934 RNF146 1.06 15.51 0.69 4.62e-39 Breast cancer; CESC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg12463550 chr7:65579703 CRCP 0.49 6.11 0.35 3.61e-9 Aortic root size; CESC cis rs10751667 0.560 rs7924794 chr11:962745 A/T cg20946044 chr11:1010712 AP2A2 -0.38 -5.24 -0.31 3.33e-7 Alzheimer's disease (late onset); CESC cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg20503657 chr10:835505 NA -1.04 -9.71 -0.51 2.96e-19 Eosinophil percentage of granulocytes; CESC cis rs4423214 1.000 rs12790558 chr11:71170905 T/C cg05163923 chr11:71159392 DHCR7 0.78 10.34 0.54 2.91e-21 Vitamin D levels; CESC cis rs1797081 1.000 rs812426 chr10:16857133 C/G cg23933602 chr10:16859644 RSU1 1.13 23.72 0.82 1.72e-67 Platelet distribution width; CESC trans rs1728785 1.000 rs1170426 chr16:68603798 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.93 0.44 6e-14 Ulcerative colitis; CESC cis rs7555523 0.887 rs2814471 chr1:165739598 C/T cg24409356 chr1:165738333 TMCO1 0.99 8.52 0.46 1.2e-15 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs637571 0.512 rs660118 chr11:65735174 G/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.42 6.14 0.35 2.94e-9 Eosinophil percentage of white cells; CESC trans rs7395662 0.500 rs1304199 chr11:48699032 A/G cg15704280 chr7:45808275 SEPT13 -0.51 -6.12 -0.35 3.31e-9 HDL cholesterol; CESC cis rs36051895 0.659 rs7045491 chr9:5045658 G/A cg02405213 chr9:5042618 JAK2 -0.43 -5.31 -0.31 2.36e-7 Pediatric autoimmune diseases; CESC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg02725872 chr8:58115012 NA -0.45 -6.84 -0.39 5.31e-11 Developmental language disorder (linguistic errors); CESC cis rs1707322 1.000 rs6682683 chr1:46342337 A/G cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg13206674 chr6:150067644 NUP43 0.42 5.83 0.34 1.65e-8 Lung cancer; CESC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg07308232 chr7:1071921 C7orf50 -0.53 -7.31 -0.41 3.11e-12 Longevity;Endometriosis; CESC cis rs193541 0.632 rs7735618 chr5:122176245 C/G cg19412675 chr5:122181750 SNX24 0.45 5.22 0.31 3.69e-7 Glucose homeostasis traits; CESC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg04553112 chr3:125709451 NA -0.54 -5.82 -0.34 1.71e-8 Blood pressure (smoking interaction); CESC cis rs3862030 0.503 rs6584506 chr10:104254428 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs7674212 0.539 rs7676041 chr4:104126421 T/A cg16532752 chr4:104119610 CENPE -0.4 -5.46 -0.32 1.09e-7 Type 2 diabetes; CESC cis rs1448094 0.549 rs4919770 chr12:86238050 G/T cg00310523 chr12:86230176 RASSF9 0.35 5.23 0.31 3.47e-7 Major depressive disorder; CESC cis rs9640161 0.742 rs2108854 chr7:150017408 C/T cg10018233 chr7:150070692 REPIN1 -0.44 -7.09 -0.4 1.21e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs12477438 0.765 rs6737257 chr2:99683330 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs6736093 0.799 rs13025651 chr2:112777853 A/G cg12686935 chr2:112915763 FBLN7 -0.41 -5.32 -0.31 2.2e-7 Coronary artery disease; CESC cis rs634534 0.591 rs688862 chr11:65733393 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.55 7.17 0.4 7.59e-12 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs796364 0.951 rs281776 chr2:200834282 T/G cg23649088 chr2:200775458 C2orf69 0.54 5.16 0.3 4.75e-7 Schizophrenia; CESC cis rs6502050 0.765 rs6502074 chr17:80121776 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.24 -0.31 3.29e-7 Life satisfaction; CESC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg23034840 chr1:205782522 SLC41A1 0.63 7.43 0.42 1.46e-12 Menarche (age at onset); CESC cis rs9902453 0.904 rs7219456 chr17:28374112 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.69 -0.47 3.79e-16 Coffee consumption (cups per day); CESC cis rs2832077 0.527 rs59730679 chr21:30226244 T/C cg24692254 chr21:30365293 RNF160 -0.66 -9.15 -0.49 1.56e-17 Cognitive test performance; CESC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.67 6.46 0.37 5.02e-10 LDL cholesterol;Cholesterol, total; CESC cis rs113835537 0.529 rs7950407 chr11:66258006 A/G cg24851651 chr11:66362959 CCS 0.45 5.77 0.33 2.24e-8 Airway imaging phenotypes; CESC cis rs7100689 0.646 rs2095994 chr10:82127956 G/A cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs10911251 0.546 rs10911260 chr1:183106230 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.79 -12.58 -0.61 9.29e-29 Colorectal cancer; CESC cis rs1018836 0.923 rs4735256 chr8:91612145 C/G cg16814680 chr8:91681699 NA -0.71 -10.08 -0.53 1.96e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg06221963 chr1:154839813 KCNN3 -0.66 -11.39 -0.57 1.03e-24 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23274912 chr8:67898781 NA -0.55 -6.35 -0.36 9.32e-10 Gut microbiome composition (summer); CESC cis rs80130819 0.748 rs2932095 chr12:48658212 C/T cg05342945 chr12:48394962 COL2A1 -0.49 -5.26 -0.31 3.01e-7 Prostate cancer; CESC cis rs911555 0.755 rs7148567 chr14:103882234 C/T cg12935359 chr14:103987150 CKB -0.56 -8.0 -0.44 3.82e-14 Intelligence (multi-trait analysis); CESC cis rs9583531 0.600 rs4773241 chr13:111363021 A/G cg24331049 chr13:111365604 ING1 0.8 11.87 0.59 2.44e-26 Coronary artery disease; CESC cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg02574844 chr11:5959923 NA -0.45 -5.47 -0.32 1.05e-7 DNA methylation (variation); CESC cis rs2290159 0.800 rs60953453 chr3:12654921 C/A cg23032965 chr3:12705835 RAF1 0.54 5.86 0.34 1.35e-8 Cholesterol, total; CESC cis rs9902453 0.689 rs56788338 chr17:28186557 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 8.8 0.48 1.86e-16 Coffee consumption (cups per day); CESC trans rs877282 1.000 rs2004479 chr10:770854 G/A cg22713356 chr15:30763199 NA 1.15 11.42 0.57 7.63e-25 Uric acid levels; CESC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg18252515 chr7:66147081 NA -0.47 -6.41 -0.37 6.57e-10 Aortic root size; CESC cis rs919433 0.927 rs13032495 chr2:198189346 C/T cg20885578 chr2:198174922 NA -0.4 -5.28 -0.31 2.73e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18466340 chr20:50417476 SALL4 -0.47 -6.51 -0.37 3.81e-10 Gut microbiota (bacterial taxa); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg00930706 chr16:88752925 MGC23284;SNAI3 -0.42 -6.26 -0.36 1.54e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21229253 chr9:134406525 UCK1 -0.45 -6.07 -0.35 4.38e-9 Fibrinogen levels; CESC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg07507251 chr3:52567010 NT5DC2 0.32 5.5 0.32 8.74e-8 Bipolar disorder; CESC cis rs11098499 0.909 rs10014719 chr4:120320715 G/A cg09307838 chr4:120376055 NA 0.91 12.48 0.61 2.07e-28 Corneal astigmatism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24218925 chr19:2578938 GNG7 -0.43 -6.39 -0.37 7.41e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg23172400 chr8:95962367 TP53INP1 0.4 7.44 0.42 1.38e-12 Type 2 diabetes; CESC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.3e-16 Colonoscopy-negative controls vs population controls; CESC cis rs78456975 0.527 rs10184112 chr2:1571112 A/G cg26248373 chr2:1572462 NA -0.6 -6.98 -0.39 2.43e-11 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs17826219 0.568 rs7213925 chr17:29121634 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Body mass index; CESC cis rs9291683 0.609 rs12507050 chr4:10007305 G/T cg02734326 chr4:10020555 SLC2A9 0.48 7.12 0.4 1.02e-11 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16731429 chr12:122268654 SETD1B -0.64 -7.97 -0.44 4.76e-14 Gut microbiome composition (summer); CESC cis rs7647973 0.626 rs4855846 chr3:49683526 G/A cg06212747 chr3:49208901 KLHDC8B 0.64 7.76 0.43 1.84e-13 Menarche (age at onset); CESC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg22907277 chr7:1156413 C7orf50 0.36 5.12 0.3 5.74e-7 Longevity;Endometriosis; CESC cis rs7017914 0.967 rs12679261 chr8:71844649 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.18 -0.3 4.4e-7 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02855078 chr16:188863 C16orf35 -0.7 -8.67 -0.47 4.28e-16 Gut microbiome composition (summer); CESC cis rs10789491 1.000 rs4097354 chr1:47187073 T/G cg15501359 chr1:47185051 KIAA0494 0.75 7.97 0.44 4.62e-14 Response to hepatitis C treatment; CESC cis rs875971 0.651 rs313829 chr7:65552497 A/G cg18876405 chr7:65276391 NA -0.45 -5.35 -0.31 1.89e-7 Aortic root size; CESC cis rs116095464 0.614 rs56299325 chr5:220594 C/T cg10591111 chr5:226296 SDHA -0.51 -6.35 -0.36 9.22e-10 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02931907 chr8:94753245 RBM12B -0.55 -6.49 -0.37 4.19e-10 Gut microbiome composition (summer); CESC cis rs752010 0.746 rs10890146 chr1:42089389 G/A cg06885757 chr1:42089581 HIVEP3 0.53 9.1 0.49 2.23e-17 Lupus nephritis in systemic lupus erythematosus; CESC cis rs155076 1.000 rs2783107 chr13:21837532 C/A cg11317459 chr13:21872234 NA -1.01 -10.78 -0.55 1.07e-22 White matter hyperintensity burden; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05642746 chr17:8024095 HES7 0.48 6.78 0.38 7.79e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs897984 0.511 rs7196726 chr16:31092075 G/A cg00531865 chr16:30841666 NA -0.39 -5.47 -0.32 1.03e-7 Dementia with Lewy bodies; CESC cis rs3092073 0.624 rs3848719 chr20:44596545 G/A cg27529037 chr20:44575021 PCIF1 0.64 9.82 0.52 1.25e-19 Intelligence (multi-trait analysis); CESC cis rs7949030 0.588 rs2512562 chr11:62312156 A/G cg02375832 chr11:62437615 C11orf48 -0.36 -5.27 -0.31 2.83e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7944584 0.511 rs10838731 chr11:47607135 C/T cg10504702 chr11:47789108 FNBP4 0.42 5.22 0.31 3.66e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC trans rs61931739 0.500 rs7979769 chr12:34509522 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.31e-22 Morning vs. evening chronotype; CESC cis rs12136530 0.681 rs6426798 chr1:19719728 C/T cg25210609 chr1:19642293 PQLC2 0.3 5.11 0.3 6.15e-7 Lead levels in blood; CESC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg07167872 chr1:205819463 PM20D1 0.73 11.69 0.58 1.01e-25 Menarche (age at onset); CESC cis rs4683142 0.518 rs4682801 chr3:46021218 G/T cg18004856 chr3:46029278 FYCO1 0.4 5.47 0.32 1.03e-7 Methadone dose in opioid dependence; CESC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg22508957 chr16:3507546 NAT15 0.57 9.47 0.5 1.63e-18 Tuberculosis; CESC cis rs611744 0.573 rs674580 chr8:109251690 C/G cg21045802 chr8:109455806 TTC35 0.56 7.02 0.4 1.89e-11 Dupuytren's disease; CESC cis rs9916302 0.904 rs9905432 chr17:37555918 C/A cg07936489 chr17:37558343 FBXL20 0.8 11.5 0.58 4.2e-25 Glomerular filtration rate (creatinine); CESC cis rs703842 0.616 rs10877023 chr12:58224199 C/A cg02175503 chr12:58329896 NA 0.47 5.76 0.33 2.28e-8 Multiple sclerosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04902049 chr1:36622448 MAP7D1 0.49 6.57 0.37 2.71e-10 Gut microbiota (bacterial taxa); CESC cis rs8180040 0.587 rs1466741 chr3:47247214 C/T cg27129171 chr3:47204927 SETD2 -0.65 -9.57 -0.51 8.03e-19 Colorectal cancer; CESC cis rs5758659 0.714 rs2413668 chr22:42505841 G/A cg15557168 chr22:42548783 NA 0.43 6.72 0.38 1.11e-10 Cognitive function; CESC cis rs12971120 0.947 rs34676212 chr18:72170006 A/G cg25817165 chr18:72167213 CNDP2 -0.57 -7.93 -0.44 6.09e-14 Refractive error; CESC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.05 0.59 5.97e-27 Alzheimer's disease; CESC trans rs9784649 0.641 rs72755823 chr5:25075537 T/C cg08600765 chr20:34638493 LOC647979 -0.66 -6.82 -0.39 6.2e-11 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6460942 0.591 rs62448729 chr7:12333720 G/C cg20607287 chr7:12443886 VWDE -0.63 -6.83 -0.39 5.83e-11 Coronary artery disease; CESC cis rs11711311 1.000 rs12497716 chr3:113453258 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.64 8.85 0.48 1.26e-16 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00429618 chr9:99962350 ZNF322B -0.59 -7.24 -0.41 4.91e-12 Gut microbiome composition (summer); CESC cis rs1707322 0.927 rs6690386 chr1:46253011 C/T cg03146154 chr1:46216737 IPP 0.79 11.17 0.57 5.6e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7512552 0.839 rs1260367 chr1:150344514 C/T cg15654264 chr1:150340011 RPRD2 0.39 5.25 0.31 3.16e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs4642101 0.765 rs6791647 chr3:12826425 C/T cg24848339 chr3:12840334 CAND2 -0.39 -6.07 -0.35 4.37e-9 QRS complex (12-leadsum); CESC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg26338869 chr17:61819248 STRADA 0.69 9.21 0.49 1.05e-17 Prudent dietary pattern; CESC cis rs881375 0.715 rs10818482 chr9:123648085 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.41 -5.67 -0.33 3.75e-8 Rheumatoid arthritis; CESC cis rs798766 0.779 rs3134866 chr4:1723265 A/G cg05874882 chr4:1763078 NA -0.6 -8.45 -0.46 1.98e-15 Bladder cancer;Urinary bladder cancer; CESC cis rs11696501 0.694 rs6073825 chr20:44258217 T/C cg11783356 chr20:44313418 WFDC10B -0.35 -5.38 -0.31 1.63e-7 Brain structure; CESC cis rs1062177 0.756 rs2915817 chr5:151115517 T/C cg00977110 chr5:151150581 G3BP1 -0.6 -6.41 -0.37 6.53e-10 Preschool internalizing problems; CESC cis rs7647973 0.626 rs2131108 chr3:49665390 C/T cg06212747 chr3:49208901 KLHDC8B 0.58 7.06 0.4 1.45e-11 Menarche (age at onset); CESC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.07 -0.44 2.52e-14 Personality dimensions; CESC trans rs11252926 0.565 rs60553947 chr10:474284 T/C cg00953403 chr17:74099816 EXOC7 -0.55 -7.01 -0.4 2.01e-11 Psychosis in Alzheimer's disease; CESC cis rs6433857 0.536 rs1542035 chr2:181351114 T/C cg23363182 chr2:181467187 NA -0.42 -5.93 -0.34 9.42e-9 Body mass index; CESC cis rs2046867 0.862 rs67961837 chr3:72840877 T/G cg25664220 chr3:72788482 NA -0.46 -6.57 -0.37 2.63e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs12586317 0.547 rs10146699 chr14:35483577 G/A cg05294307 chr14:35346193 BAZ1A -0.51 -5.48 -0.32 1.01e-7 Psoriasis; CESC cis rs7772486 0.902 rs2777480 chr6:146309983 T/A cg05347473 chr6:146136440 FBXO30 0.5 6.72 0.38 1.08e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs568617 1.000 rs641018 chr11:65655393 G/C cg00576331 chr11:65640516 EFEMP2 -0.45 -5.35 -0.31 1.95e-7 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02804028 chr22:31031786 SLC35E4 0.62 6.86 0.39 4.98e-11 Gut microbiome composition (summer); CESC cis rs10504229 0.679 rs16921683 chr8:58053270 T/C cg02725872 chr8:58115012 NA -0.33 -5.04 -0.3 8.84e-7 Developmental language disorder (linguistic errors); CESC cis rs12681366 0.537 rs2197004 chr8:95456976 A/G cg13257157 chr8:95487014 RAD54B 0.45 5.47 0.32 1.05e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs372883 0.530 rs2832305 chr21:30752964 G/A cg24692254 chr21:30365293 RNF160 0.48 5.88 0.34 1.21e-8 Pancreatic cancer; CESC cis rs78456975 1.000 rs11891809 chr2:1566001 A/G cg26248373 chr2:1572462 NA -0.54 -5.23 -0.31 3.39e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs2832191 0.740 rs2853830 chr21:30416824 A/G cg24692254 chr21:30365293 RNF160 1.02 18.19 0.75 1.5e-48 Dental caries; CESC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg12463550 chr7:65579703 CRCP -0.45 -5.79 -0.34 1.98e-8 Aortic root size; CESC cis rs4253772 0.591 rs11704586 chr22:46685274 T/C cg10541313 chr22:46663664 TTC38 0.72 5.15 0.3 5.01e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2944591 0.505 rs2592127 chr2:233791648 G/T cg11972305 chr2:233791962 NGEF -0.33 -5.44 -0.32 1.23e-7 Autism spectrum disorder or schizophrenia; CESC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg20151795 chr6:28129481 ZNF389 0.42 5.47 0.32 1.03e-7 Parkinson's disease; CESC cis rs72945132 0.660 rs7121703 chr11:70140296 C/T cg14191688 chr11:70257035 CTTN 0.41 5.27 0.31 2.9e-7 Coronary artery disease; CESC cis rs72781680 1.000 rs963725 chr2:24148231 T/C cg08917208 chr2:24149416 ATAD2B 1.1 9.84 0.52 1.09e-19 Lymphocyte counts; CESC cis rs3540 0.533 rs4932342 chr15:90982923 C/T cg22089800 chr15:90895588 ZNF774 0.62 8.35 0.46 3.88e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg22535103 chr8:58192502 C8orf71 -0.76 -8.74 -0.47 2.65e-16 Developmental language disorder (linguistic errors); CESC cis rs77106637 0.932 rs2886599 chr11:72721271 C/A cg03713592 chr11:72463424 ARAP1 1.2 10.8 0.55 8.75e-23 Type 2 diabetes; CESC cis rs4780401 0.728 rs6498239 chr16:11780774 T/C cg01061890 chr16:11836724 TXNDC11 -0.47 -6.22 -0.36 1.93e-9 Rheumatoid arthritis; CESC cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg27286337 chr10:134555280 INPP5A 0.67 7.89 0.44 8.2e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1355223 0.902 rs34875830 chr11:34722205 T/C cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.19 -0.36 2.26e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg08231274 chr14:57735852 MUDENG;EXOC5 -0.45 -5.99 -0.35 6.66e-9 Height; CESC cis rs72781680 0.898 rs72796152 chr2:23933626 G/A cg08917208 chr2:24149416 ATAD2B 0.97 8.89 0.48 9.92e-17 Lymphocyte counts; CESC cis rs7524258 0.868 rs10779678 chr1:7300573 A/G cg07173049 chr1:7289937 CAMTA1 0.42 6.3 0.36 1.23e-9 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs66573146 0.572 rs73199995 chr4:6955801 G/C cg00086871 chr4:6988644 TBC1D14 1.05 6.88 0.39 4.36e-11 Granulocyte percentage of myeloid white cells; CESC cis rs258892 0.895 rs253169 chr5:72118987 G/A cg21869765 chr5:72125136 TNPO1 -0.44 -5.65 -0.33 4.05e-8 Small cell lung carcinoma; CESC cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg13877915 chr19:58951672 ZNF132 0.39 5.81 0.34 1.83e-8 Uric acid clearance; CESC cis rs763121 0.853 rs5750671 chr22:39094619 A/C cg21395723 chr22:39101663 GTPBP1 0.49 6.67 0.38 1.5e-10 Menopause (age at onset); CESC cis rs2243480 1.000 rs73142122 chr7:65311298 C/A cg25894440 chr7:65020034 NA -0.63 -5.42 -0.32 1.33e-7 Diabetic kidney disease; CESC cis rs1153858 1.000 rs11070457 chr15:45686943 A/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.88 0.34 1.22e-8 Homoarginine levels; CESC cis rs7826238 0.720 rs12546760 chr8:8374836 A/G cg15556689 chr8:8085844 FLJ10661 -0.47 -5.73 -0.33 2.76e-8 Systolic blood pressure; CESC cis rs7762018 1.000 rs74900588 chr6:170102180 A/C cg05834625 chr6:170176447 C6orf70 0.63 7.6 0.42 5.01e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4523957 0.928 rs216183 chr17:2173923 A/G cg16513277 chr17:2031491 SMG6 0.59 7.99 0.44 4.21e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs868036 0.681 rs4776375 chr15:68085555 G/A cg08079166 chr15:68083412 MAP2K5 0.35 5.1 0.3 6.47e-7 Restless legs syndrome; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02139671 chr12:123237174 DENR -0.42 -5.99 -0.35 6.67e-9 Gambling; CESC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -9.98 -0.52 4.19e-20 Alzheimer's disease; CESC trans rs61931739 0.517 rs10844738 chr12:34059503 T/A cg26384229 chr12:38710491 ALG10B 0.52 6.94 0.39 2.96e-11 Morning vs. evening chronotype; CESC cis rs7727544 0.660 rs2631361 chr5:131707380 C/A cg24060327 chr5:131705240 SLC22A5 0.63 8.33 0.46 4.43e-15 Blood metabolite levels; CESC cis rs11711311 1.000 rs6792447 chr3:113508335 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.16 0.53 1.1e-20 IgG glycosylation; CESC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.48 0.64 7.04e-32 Prudent dietary pattern; CESC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg02569458 chr12:86230093 RASSF9 0.58 8.51 0.46 1.31e-15 Major depressive disorder; CESC cis rs763121 0.853 rs5750649 chr22:39036769 T/C cg06544989 chr22:39130855 UNC84B 0.5 9.27 0.49 6.78e-18 Menopause (age at onset); CESC cis rs9287719 0.614 rs10929678 chr2:10723095 T/C cg00105475 chr2:10696890 NA 0.39 5.27 0.31 2.83e-7 Prostate cancer; CESC trans rs35110281 0.805 rs2838319 chr21:44991901 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 6.9 0.39 3.88e-11 Mean corpuscular volume; CESC cis rs10876993 0.789 rs1689600 chr12:58049645 A/T cg18357645 chr12:58087776 OS9 0.61 9.28 0.5 6.32e-18 Celiac disease or Rheumatoid arthritis; CESC cis rs763121 0.853 rs3788545 chr22:39065172 A/G cg14440974 chr22:39074834 NA -0.41 -5.58 -0.32 6.07e-8 Menopause (age at onset); CESC cis rs4660306 1.000 rs6429567 chr1:45956700 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.86e-13 Homocysteine levels; CESC cis rs8027181 1.000 rs8027181 chr15:73088869 A/T cg25632853 chr15:73088954 NA 0.37 6.55 0.37 3.02e-10 Triglyceride levels; CESC cis rs2066819 1.000 rs11575231 chr12:56744445 T/C cg26804944 chr12:56660921 COQ10A -0.83 -5.03 -0.3 9.17e-7 Psoriasis vulgaris; CESC trans rs352242 0.721 rs9572151 chr13:69863739 T/C cg15456293 chr8:2044148 MYOM2 -0.35 -6.0 -0.35 6.47e-9 Life satisfaction; CESC cis rs34286592 1.000 rs13331733 chr16:29848417 A/G cg27338089 chr16:29820515 MAZ 0.48 5.12 0.3 6e-7 Multiple sclerosis; CESC cis rs7714584 1.000 rs12652003 chr5:150231945 T/C cg22134413 chr5:150180641 NA 0.63 6.08 0.35 4.24e-9 Crohn's disease; CESC trans rs2727020 0.521 rs11039902 chr11:48679467 A/G cg15704280 chr7:45808275 SEPT13 -0.54 -6.6 -0.38 2.19e-10 Coronary artery disease; CESC cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg22509189 chr2:225307070 NA 0.43 5.84 0.34 1.54e-8 IgE levels in asthmatics (D.p. specific); CESC cis rs72781680 0.716 rs2712079 chr2:24082061 G/A cg08917208 chr2:24149416 ATAD2B 0.54 5.49 0.32 9.3e-8 Lymphocyte counts; CESC cis rs4820539 1.000 rs5751589 chr22:23475762 A/G cg14186256 chr22:23484241 RTDR1 -0.8 -13.93 -0.65 1.82e-33 Bone mineral density; CESC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs7177699 0.557 rs3971829 chr15:79109052 A/G cg04896959 chr15:78267971 NA -0.33 -5.11 -0.3 6.19e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs9399137 0.507 rs12664898 chr6:135288663 T/C cg24558204 chr6:135376177 HBS1L 0.7 9.52 0.5 1.15e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10869401 chr11:129802046 PRDM10 0.46 6.02 0.35 5.72e-9 Fibrinogen levels; CESC cis rs9814567 0.896 rs58491661 chr3:134355189 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.42 5.65 0.33 4.22e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs8020095 0.571 rs6573752 chr14:67589792 T/G cg19548862 chr14:67692701 FAM71D -0.51 -6.26 -0.36 1.56e-9 Depression (quantitative trait); CESC cis rs12477438 0.765 rs12468807 chr2:99691994 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs9486719 1.000 rs3798296 chr6:97052286 G/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.76 -0.33 2.36e-8 Migraine;Coronary artery disease; CESC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.79 -0.55 9.49e-23 Alzheimer's disease; CESC cis rs2014572 0.904 rs10412465 chr19:57753931 T/C cg12963866 chr19:57752005 ZNF805 -0.52 -6.96 -0.39 2.74e-11 Hyperactive-impulsive symptoms; CESC cis rs72634258 0.945 rs67717282 chr1:8041290 C/T cg00042356 chr1:8021962 PARK7 0.82 7.56 0.42 6.62e-13 Inflammatory bowel disease; CESC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg13206674 chr6:150067644 NUP43 0.42 5.53 0.32 7.67e-8 Lung cancer; CESC cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg14345882 chr6:26364793 BTN3A2 0.41 5.12 0.3 5.79e-7 Intelligence (multi-trait analysis); CESC cis rs9908102 0.740 rs7211210 chr17:12917352 A/G cg26162695 chr17:12921313 ELAC2 0.55 5.9 0.34 1.12e-8 Schizophrenia; CESC cis rs11098499 0.820 rs13128602 chr4:120459366 C/T cg09307838 chr4:120376055 NA -0.88 -12.11 -0.6 3.78e-27 Corneal astigmatism; CESC cis rs3741151 0.773 rs7945825 chr11:73287140 G/C cg17517138 chr11:73019481 ARHGEF17 1.02 7.43 0.42 1.51e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs1801251 1.000 rs12478564 chr2:233598340 C/T cg25237894 chr2:233734115 C2orf82 0.45 7.81 0.43 1.36e-13 Coronary artery disease; CESC cis rs2070488 0.896 rs11914389 chr3:38527215 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.94 16.97 0.72 3.05e-44 Electrocardiographic conduction measures; CESC trans rs7839040 0.698 rs13249759 chr8:82931534 A/T cg14472086 chr9:107730925 NA -0.48 -6.45 -0.37 5.4e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs10170846 0.861 rs12694582 chr2:223521955 G/C cg25565276 chr2:223520875 FARSB 0.5 6.98 0.39 2.39e-11 Schizophrenia (inflammation and infection response interaction); CESC cis rs8067354 0.645 rs72840522 chr17:57829992 G/A cg02344993 chr17:57696989 CLTC 0.68 8.07 0.44 2.5e-14 Hemoglobin concentration; CESC cis rs4906332 0.868 rs4900578 chr14:103926010 A/T cg09975044 chr14:104007538 NA 0.47 6.45 0.37 5.25e-10 Coronary artery disease; CESC cis rs858239 0.699 rs858260 chr7:23212934 G/T cg23682824 chr7:23144976 KLHL7 0.46 5.92 0.34 1.02e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7116495 0.609 rs73543643 chr11:71835596 C/T cg26138937 chr11:71823887 C11orf51 1.23 7.77 0.43 1.75e-13 Severe influenza A (H1N1) infection; CESC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.25 0.41 4.65e-12 Height; CESC cis rs7772486 0.790 rs9791313 chr6:146266172 T/C cg05347473 chr6:146136440 FBXO30 -0.52 -6.88 -0.39 4.23e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11064206 chr12:123459532 OGFOD2;ABCB9 0.48 6.28 0.36 1.37e-9 Gut microbiota (bacterial taxa); CESC cis rs1797885 0.510 rs2633442 chr3:12609937 A/G cg26432171 chr3:12704882 RAF1 0.4 5.24 0.31 3.34e-7 Immature fraction of reticulocytes; CESC cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg02297831 chr4:17616191 MED28 0.52 5.94 0.34 8.76e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2180341 0.889 rs9321074 chr6:127618019 G/A cg27446573 chr6:127587934 RNF146 1.08 16.13 0.7 3.14e-41 Breast cancer; CESC cis rs6963495 0.745 rs73190169 chr7:105160500 A/G cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs8044868 0.586 rs7199261 chr16:72082788 A/G cg01557791 chr16:72042693 DHODH -0.43 -5.89 -0.34 1.17e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs9487051 0.676 rs4383852 chr6:109594475 G/A cg12927641 chr6:109611667 NA -0.37 -5.56 -0.32 6.55e-8 Reticulocyte fraction of red cells; CESC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg08736216 chr1:53307985 ZYG11A 0.43 7.24 0.41 4.72e-12 Monocyte count; CESC cis rs145445141 1 rs145445141 chr1:67489169 ATT/A cg02640540 chr1:67518911 SLC35D1 0.6 6.16 0.35 2.73e-9 Neutrophil percentage of white cells; CESC cis rs4243830 0.737 rs925745 chr1:6615690 A/G cg04093404 chr1:6614507 TAS1R1;NOL9 0.55 5.04 0.3 8.45e-7 Body mass index; CESC cis rs3096299 0.728 rs1011749 chr16:89510869 G/C cg02187348 chr16:89574699 SPG7 0.65 9.22 0.49 9.59e-18 Multiple myeloma (IgH translocation); CESC cis rs727505 0.866 rs73227503 chr7:124721044 A/G cg23710748 chr7:124431027 NA -0.4 -6.52 -0.37 3.56e-10 Lewy body disease; CESC trans rs4569005 0.610 rs11605578 chr11:21063299 C/G cg05396178 chr6:27833129 HIST1H2AL 0.63 6.07 0.35 4.51e-9 Adverse response to lamotrigine and phenytoin; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg08265790 chr5:141704696 SPRY4 0.51 6.97 0.39 2.49e-11 Thyroid stimulating hormone; CESC cis rs6714710 0.603 rs1470483 chr2:98393894 C/T cg26665480 chr2:98280029 ACTR1B 0.67 9.22 0.49 9.72e-18 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs7103648 0.966 rs1377416 chr11:47416746 C/T cg03711944 chr11:47377212 SPI1 -0.31 -5.06 -0.3 7.99e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs9611565 0.592 rs5751101 chr22:41828111 C/T cg06481639 chr22:41940642 POLR3H 0.63 6.31 0.36 1.18e-9 Vitiligo; CESC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.11 -0.3 6.23e-7 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.863 rs11933966 chr4:120476715 G/A cg09307838 chr4:120376055 NA 0.91 12.68 0.61 4e-29 Corneal astigmatism; CESC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.82 10.45 0.54 1.29e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg21138405 chr5:131827807 IRF1 -0.36 -5.38 -0.31 1.63e-7 Breast cancer;Mosquito bite size; CESC cis rs6964587 1.000 rs10234290 chr7:91716951 T/C cg17063962 chr7:91808500 NA 0.58 8.06 0.44 2.57e-14 Breast cancer; CESC cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg23283495 chr1:209979779 IRF6 0.48 5.59 0.32 5.57e-8 Cleft lip with or without cleft palate; CESC cis rs868036 1.000 rs868037 chr15:68054996 A/G cg08079166 chr15:68083412 MAP2K5 -0.42 -6.59 -0.38 2.35e-10 Restless legs syndrome; CESC cis rs713587 0.607 rs6725517 chr2:25129473 A/G cg01884057 chr2:25150051 NA 0.34 6.46 0.37 4.88e-10 Body mass index in non-asthmatics; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13749939 chr11:796434 SLC25A22 0.48 6.39 0.37 7.54e-10 Gut microbiota (bacterial taxa); CESC cis rs4891159 0.548 rs10782013 chr18:74128348 C/T cg24786174 chr18:74118243 ZNF516 0.84 15.96 0.7 1.24e-40 Longevity; CESC cis rs7520050 0.931 rs6686134 chr1:46378268 A/G cg03146154 chr1:46216737 IPP -0.48 -6.19 -0.36 2.33e-9 Red blood cell count;Reticulocyte count; CESC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.39 -6.23 -0.36 1.84e-9 Personality dimensions; CESC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg13798912 chr7:905769 UNC84A -0.56 -5.63 -0.33 4.56e-8 Cerebrospinal P-tau181p levels; CESC trans rs6084875 0.641 rs4813712 chr20:4722741 A/C cg10192164 chr16:30419175 ZNF771 -0.5 -6.13 -0.35 3.1e-9 Systemic lupus erythematosus; CESC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg00149659 chr3:10157352 C3orf10 0.7 8.38 0.46 3.2e-15 Alzheimer's disease; CESC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg17279839 chr7:150038598 RARRES2 0.51 5.96 0.34 8.14e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg09177884 chr7:1199841 ZFAND2A -0.65 -8.85 -0.48 1.27e-16 Longevity;Endometriosis; CESC cis rs1050631 0.592 rs1785932 chr18:33719434 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.53 7.16 0.4 7.87e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg21963583 chr11:68658836 MRPL21 0.38 5.59 0.32 5.63e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10465746 0.935 rs12406984 chr1:84416215 C/G cg10977910 chr1:84465055 TTLL7 0.48 6.47 0.37 4.67e-10 Obesity-related traits; CESC cis rs3749237 0.964 rs11714957 chr3:49776178 C/T cg03060546 chr3:49711283 APEH 0.63 7.39 0.41 1.93e-12 Resting heart rate; CESC cis rs3862030 0.503 rs6584506 chr10:104254428 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg27057461 chr7:158136379 PTPRN2 -0.32 -5.17 -0.3 4.6e-7 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10504545 chr14:74769802 ABCD4 0.59 6.69 0.38 1.29e-10 Gut microbiome composition (summer); CESC cis rs992157 0.710 rs7569907 chr2:219070551 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.56 0.51 8.5e-19 Colorectal cancer; CESC cis rs7017914 0.967 rs13261712 chr8:71732264 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.44 -5.68 -0.33 3.58e-8 Bone mineral density; CESC cis rs9896933 0.723 rs7224189 chr17:80782227 C/T cg19500275 chr17:80737654 TBCD 0.63 6.52 0.37 3.49e-10 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs12681288 0.523 rs11137122 chr8:954702 A/G cg15309053 chr8:964076 NA 0.51 8.49 0.46 1.48e-15 Schizophrenia; CESC cis rs1568889 0.712 rs10835306 chr11:28302410 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.99 0.65 1.11e-33 Bipolar disorder; CESC cis rs5769707 0.642 rs135880 chr22:50018654 T/A cg05373962 chr22:49881684 NA -0.33 -5.15 -0.3 5.18e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.83 -9.25 -0.49 7.55e-18 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs1618893 chr7:66096119 C/T cg18252515 chr7:66147081 NA -0.87 -8.76 -0.47 2.32e-16 Diabetic kidney disease; CESC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg02725872 chr8:58115012 NA -0.43 -5.86 -0.34 1.39e-8 Developmental language disorder (linguistic errors); CESC cis rs6502050 0.835 rs7207947 chr17:80145291 A/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.29 -0.31 2.51e-7 Life satisfaction; CESC cis rs7618501 1.000 rs3749240 chr3:49750188 T/A cg24308560 chr3:49941425 MST1R 0.49 6.69 0.38 1.29e-10 Intelligence (multi-trait analysis); CESC cis rs2073300 0.609 rs2295238 chr20:23387946 C/G cg12062639 chr20:23401060 NAPB 0.85 7.66 0.43 3.47e-13 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1707322 1.000 rs6695421 chr1:46380207 T/C cg06784218 chr1:46089804 CCDC17 0.33 5.69 0.33 3.36e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10304803 chr17:80771384 TBCD 0.51 6.84 0.39 5.5e-11 Fibrinogen levels; CESC cis rs9660992 0.736 rs1180734 chr1:205255438 A/G cg21643547 chr1:205240462 TMCC2 -0.48 -7.48 -0.42 1.11e-12 Mean corpuscular volume;Mean platelet volume; CESC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg22903657 chr4:1355424 KIAA1530 0.41 5.66 0.33 3.87e-8 Obesity-related traits; CESC cis rs75804782 0.521 rs55973123 chr2:239416264 G/A cg18131467 chr2:239335373 ASB1 -0.62 -5.07 -0.3 7.48e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs1042058 0.565 rs2480297 chr10:30754512 A/G cg25182066 chr10:30743637 MAP3K8 -0.5 -7.05 -0.4 1.6e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs6964587 1.000 rs2299238 chr7:91654517 G/A cg17063962 chr7:91808500 NA 0.58 8.02 0.44 3.36e-14 Breast cancer; CESC cis rs11785400 0.793 rs6996760 chr8:143722386 G/A cg10596483 chr8:143751796 JRK 0.4 5.14 0.3 5.32e-7 Schizophrenia; CESC cis rs7336332 0.598 rs45622135 chr13:28011594 T/C cg22138327 chr13:27999177 GTF3A 0.62 5.82 0.34 1.71e-8 Weight; CESC cis rs2342371 0.545 rs7646273 chr3:196210894 T/C cg15048948 chr3:196158458 UBXN7 -0.39 -5.5 -0.32 9.12e-8 Fat distribution (HIV); CESC cis rs7945705 0.875 rs10769955 chr11:8784647 G/C cg12365402 chr11:9010492 NRIP3 0.35 5.33 0.31 2.1e-7 Hemoglobin concentration; CESC trans rs2727020 0.637 rs1164673 chr11:49328356 C/G cg03929089 chr4:120376271 NA 0.55 6.91 0.39 3.65e-11 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07237882 chr5:137090689 HNRNPA0 -0.45 -6.33 -0.36 1.07e-9 Fibrinogen levels; CESC cis rs10208940 0.841 rs7598760 chr2:68837054 A/G cg12452813 chr2:68675892 NA 0.51 5.12 0.3 5.95e-7 Urate levels in lean individuals; CESC cis rs8067354 0.645 rs2645486 chr17:57885901 T/A cg13753209 chr17:57696993 CLTC 0.66 8.26 0.45 7.21e-15 Hemoglobin concentration; CESC cis rs7680126 0.536 rs3796841 chr4:10007904 C/T cg11266682 chr4:10021025 SLC2A9 0.44 5.07 0.3 7.4e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs2710642 0.849 rs4671450 chr2:62981869 C/A cg17519650 chr2:63277830 OTX1 -0.59 -7.61 -0.42 4.72e-13 LDL cholesterol levels;LDL cholesterol; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08862778 chr1:11322643 MTOR 0.48 6.43 0.37 5.83e-10 Gut microbiota (bacterial taxa); CESC cis rs10851478 0.872 rs4775816 chr15:49871503 A/C cg08060515 chr15:49448048 GALK2;COPS2 0.43 5.23 0.31 3.45e-7 Oral cavity cancer; CESC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg21984481 chr17:79567631 NPLOC4 -0.49 -8.04 -0.44 2.97e-14 Eye color traits; CESC cis rs9790314 1.000 rs6775627 chr3:160953609 A/G cg04691961 chr3:161091175 C3orf57 -0.41 -5.2 -0.3 4e-7 Morning vs. evening chronotype; CESC cis rs763121 0.853 rs5750626 chr22:38977890 G/C cg06022373 chr22:39101656 GTPBP1 0.84 12.24 0.6 1.36e-27 Menopause (age at onset); CESC cis rs7107174 0.681 rs11237443 chr11:78005089 C/A cg02023728 chr11:77925099 USP35 0.44 6.09 0.35 3.87e-9 Testicular germ cell tumor; CESC cis rs6582630 0.638 rs4882309 chr12:38448595 A/G cg26384229 chr12:38710491 ALG10B -0.44 -5.94 -0.34 9.08e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg01181863 chr3:195395398 SDHAP2 0.55 7.6 0.42 5.26e-13 Bronchopulmonary dysplasia; CESC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg03517284 chr6:25882590 NA -0.43 -5.67 -0.33 3.68e-8 Intelligence (multi-trait analysis); CESC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg11890956 chr21:40555474 PSMG1 1.17 21.55 0.8 3.39e-60 Cognitive function; CESC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg11663144 chr21:46675770 NA -0.64 -10.02 -0.52 2.95e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.65 0.33 4.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12432846 chr1:85741899 BCL10 0.58 6.42 0.37 6.4e-10 Gut microbiome composition (summer); CESC cis rs951366 0.677 rs1775140 chr1:205672107 C/A cg07157834 chr1:205819609 PM20D1 0.73 10.45 0.54 1.22e-21 Menarche (age at onset); CESC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg18302933 chr2:88491318 NA -0.36 -5.34 -0.31 2e-7 Response to metformin (IC50); CESC cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg14416269 chr4:6271139 WFS1 0.43 7.02 0.4 1.86e-11 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.95 13.26 0.63 3.99e-31 IgG glycosylation; CESC cis rs2845885 1.000 rs2845885 chr11:63869062 A/G cg24431193 chr11:63883947 FLRT1;MACROD1 0.85 7.72 0.43 2.44e-13 Body mass index; CESC cis rs10883723 0.668 rs12414479 chr10:104420902 C/T cg22532475 chr10:104410764 TRIM8 -0.43 -6.53 -0.37 3.3e-10 Allergic disease (asthma, hay fever or eczema); CESC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.62 0.38 2e-10 Prudent dietary pattern; CESC cis rs6024905 0.595 rs2022499 chr20:36966531 G/T cg07053727 chr20:36965646 BPI 0.56 8.97 0.48 5.52e-17 Bipolar disorder and schizophrenia; CESC cis rs6519955 0.796 rs4072455 chr22:46422938 T/C cg05468064 chr22:46423449 NA 0.46 7.78 0.43 1.63e-13 Dupuytren's disease; CESC cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg12386194 chr3:101231763 SENP7 0.6 6.65 0.38 1.71e-10 Colonoscopy-negative controls vs population controls; CESC trans rs629535 0.814 rs558511 chr8:70069908 C/A cg21567404 chr3:27674614 NA 0.88 10.34 0.54 2.74e-21 Dupuytren's disease; CESC trans rs4665809 0.838 rs2243834 chr2:26357748 A/C cg09258813 chr8:37823409 ADRB3 0.35 6.04 0.35 5.31e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02778551 chr7:1045947 C7orf50 0.49 7.03 0.4 1.71e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6676180 0.555 rs947430 chr1:119778734 G/A cg05756136 chr1:119680316 WARS2 -0.41 -5.34 -0.31 1.95e-7 Monobrow; CESC cis rs7927771 0.524 rs61895760 chr11:47794538 G/C cg18512352 chr11:47633146 NA 0.33 5.17 0.3 4.51e-7 Subjective well-being; CESC cis rs6732160 0.691 rs1960233 chr2:73421378 A/G cg01422370 chr2:73384389 NA 0.43 7.29 0.41 3.57e-12 Intelligence (multi-trait analysis); CESC cis rs2997447 0.706 rs61776574 chr1:26429492 C/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.66 5.46 0.32 1.07e-7 QRS complex (12-leadsum); CESC cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg00677455 chr12:58241039 CTDSP2 0.53 6.97 0.39 2.57e-11 Multiple sclerosis; CESC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg27266027 chr21:40555129 PSMG1 0.45 5.32 0.31 2.19e-7 Cognitive function; CESC trans rs7448080 0.510 rs330446 chr5:123281396 A/G cg10971134 chr1:56877429 NA 0.94 6.31 0.36 1.15e-9 Alcohol dependence (age at onset); CESC cis rs8067545 0.611 rs12942568 chr17:20117893 G/T cg13482628 chr17:19912719 NA -0.43 -5.81 -0.34 1.81e-8 Schizophrenia; CESC cis rs67478160 0.584 rs12433009 chr14:104196405 C/G cg01849466 chr14:104193079 ZFYVE21 -0.56 -8.26 -0.45 7.02e-15 Schizophrenia; CESC cis rs9300255 0.602 rs1727317 chr12:123618942 T/C cg00376283 chr12:123451042 ABCB9 0.62 6.59 0.38 2.33e-10 Neutrophil percentage of white cells; CESC cis rs735396 1.000 rs1169310 chr12:121439433 G/A cg25281562 chr12:121454272 C12orf43 0.39 5.08 0.3 7.26e-7 N-glycan levels; CESC cis rs9840812 0.645 rs9883916 chr3:136208788 C/T cg15507776 chr3:136538369 TMEM22 0.51 5.62 0.33 4.77e-8 Fibrinogen levels; CESC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs920590 0.721 rs920587 chr8:19663339 C/A cg01411142 chr8:19674711 INTS10 0.52 5.83 0.34 1.64e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs1008375 0.931 rs2098151 chr4:17577490 T/C cg27347728 chr4:17578864 LAP3 0.43 5.12 0.3 5.92e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs71403859 0.570 rs78972826 chr16:71454264 A/G cg08717414 chr16:71523259 ZNF19 -0.84 -8.19 -0.45 1.1e-14 Post bronchodilator FEV1; CESC cis rs4901869 0.931 rs12891570 chr14:59334338 T/A cg02291164 chr14:59296302 NA 0.44 7.49 0.42 1.05e-12 Panic disorder; CESC trans rs7906315 0.967 rs3814573 chr10:114898093 C/T cg11368438 chr3:142751654 SR140 -0.45 -6.48 -0.37 4.54e-10 Breast cancer; CESC cis rs713587 0.520 rs493090 chr2:25303772 G/A cg01884057 chr2:25150051 NA -0.32 -5.48 -0.32 9.68e-8 Body mass index in non-asthmatics; CESC cis rs4900538 0.855 rs1209151 chr14:102893756 C/T cg18135206 chr14:102964638 TECPR2 -0.77 -9.86 -0.52 9.76e-20 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs2933343 0.951 rs1055128 chr3:128591048 C/T cg25356066 chr3:128598488 ACAD9 0.55 6.92 0.39 3.4e-11 IgG glycosylation; CESC cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg05234568 chr11:5960015 NA -0.6 -7.11 -0.4 1.08e-11 DNA methylation (variation); CESC cis rs208520 0.690 rs207108 chr6:66794096 T/C cg07460842 chr6:66804631 NA -1.0 -13.33 -0.63 2.21e-31 Exhaled nitric oxide output; CESC cis rs9733 0.744 rs12568757 chr1:150729793 C/T cg22823121 chr1:150693482 HORMAD1 -0.36 -5.44 -0.32 1.21e-7 Tonsillectomy; CESC cis rs9911578 0.900 rs717828 chr17:56535932 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.31 0.69 2.4e-38 Intelligence (multi-trait analysis); CESC trans rs561341 0.783 rs512698 chr17:30292507 G/T cg20587970 chr11:113659929 NA -1.44 -18.66 -0.75 3.36e-50 Hip circumference adjusted for BMI; CESC cis rs992157 0.560 rs7578940 chr2:219083318 G/T cg00012203 chr2:219082015 ARPC2 -0.73 -9.67 -0.51 3.83e-19 Colorectal cancer; CESC cis rs7520050 0.966 rs11211234 chr1:46438787 C/A cg24296786 chr1:45957014 TESK2 0.44 5.5 0.32 8.98e-8 Red blood cell count;Reticulocyte count; CESC cis rs372883 0.613 rs1153289 chr21:30686212 G/T cg08807101 chr21:30365312 RNF160 -0.45 -5.34 -0.31 1.99e-7 Pancreatic cancer; CESC cis rs7917772 0.503 rs7893155 chr10:104294228 C/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.81 -0.34 1.82e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs4523957 0.614 rs2984941 chr17:2031543 A/G cg16513277 chr17:2031491 SMG6 -0.71 -10.13 -0.53 1.37e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs916888 0.821 rs199505 chr17:44859410 A/G cg01570182 chr17:44337453 NA -0.87 -10.41 -0.54 1.71e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3026101 0.671 rs739768 chr17:5290703 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.69 0.33 3.37e-8 Body mass index; CESC cis rs67460515 1.000 rs67460515 chr3:161068566 T/C cg03342759 chr3:160939853 NMD3 -0.52 -7.69 -0.43 2.88e-13 Parkinson's disease; CESC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg21269045 chr12:125625041 AACS 0.36 5.57 0.32 6.29e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg05863683 chr7:1912471 MAD1L1 -0.44 -6.68 -0.38 1.39e-10 Bipolar disorder and schizophrenia; CESC cis rs62064224 0.589 rs9889607 chr17:30785585 A/C cg18200150 chr17:30822561 MYO1D -0.42 -5.63 -0.33 4.55e-8 Schizophrenia; CESC trans rs66887589 0.616 rs11098497 chr4:120187068 C/T cg25214090 chr10:38739885 LOC399744 0.43 6.02 0.35 5.75e-9 Diastolic blood pressure; CESC cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg05347473 chr6:146136440 FBXO30 -0.75 -9.41 -0.5 2.47e-18 Lobe attachment (rater-scored or self-reported); CESC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16572859 chr19:18263815 PIK3R2 0.54 6.34 0.36 9.66e-10 Gut microbiome composition (summer); CESC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.52 7.7 0.43 2.72e-13 Bipolar disorder; CESC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg24562669 chr7:97807699 LMTK2 0.48 6.94 0.39 2.98e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 10.49 0.54 9.53e-22 Platelet count; CESC cis rs2295359 1.000 rs963427 chr1:67609347 A/G cg17031739 chr1:67600172 NA 0.39 5.08 0.3 7.11e-7 Psoriasis; CESC cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg12927641 chr6:109611667 NA -0.44 -6.78 -0.38 7.73e-11 Reticulocyte fraction of red cells; CESC cis rs8092503 0.903 rs12970424 chr18:52472982 G/A cg12377874 chr18:52495404 RAB27B 0.37 5.94 0.34 8.77e-9 Childhood body mass index; CESC cis rs367943 1.000 rs348946 chr5:112822814 C/T cg12552261 chr5:112820674 MCC -0.63 -7.94 -0.44 5.83e-14 Type 2 diabetes; CESC cis rs3540 0.597 rs3539 chr15:91045419 G/T cg10434728 chr15:90938212 IQGAP1 -0.42 -7.71 -0.43 2.56e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1062177 0.906 rs2964573 chr5:151160122 A/T cg00977110 chr5:151150581 G3BP1 0.66 7.04 0.4 1.63e-11 Preschool internalizing problems; CESC trans rs2121875 0.667 rs10941659 chr5:44223360 A/T cg09056876 chr6:156718398 NA -0.48 -6.23 -0.36 1.8e-9 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06095699 chr12:100594421 ACTR6 -0.53 -6.38 -0.36 8e-10 Gut microbiome composition (summer); CESC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg12463550 chr7:65579703 CRCP 0.55 6.87 0.39 4.52e-11 Aortic root size; CESC cis rs7123876 0.830 rs59311588 chr11:72435996 A/G cg04827223 chr11:72435913 ARAP1 -0.84 -15.39 -0.69 1.27e-38 Body mass index; CESC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg19717773 chr7:2847554 GNA12 0.58 8.51 0.46 1.33e-15 Height; CESC cis rs854765 0.547 rs12150369 chr17:17911014 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.23 0.41 5.11e-12 Total body bone mineral density; CESC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg05483915 chr17:80145575 CCDC57 0.43 5.08 0.3 7.1e-7 Breast cancer; CESC cis rs8078723 0.714 rs12940405 chr17:38143768 C/T cg17467752 chr17:38218738 THRA -0.57 -8.48 -0.46 1.57e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs17376456 0.757 rs10066431 chr5:93198204 A/G cg25358565 chr5:93447407 FAM172A 1.11 10.79 0.55 9.8e-23 Diabetic retinopathy; CESC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.62 8.86 0.48 1.22e-16 Bipolar disorder; CESC cis rs9302635 0.678 rs8054585 chr16:72225314 G/A cg01557791 chr16:72042693 DHODH -0.58 -6.72 -0.38 1.08e-10 Blood protein levels; CESC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg13607699 chr17:42295918 UBTF -0.54 -7.0 -0.4 2.07e-11 Total body bone mineral density; CESC cis rs7937682 0.575 rs7124696 chr11:111747297 A/G cg22437258 chr11:111473054 SIK2 -0.47 -5.24 -0.31 3.21e-7 Primary sclerosing cholangitis; CESC cis rs258892 0.895 rs10036866 chr5:72068932 A/G cg21869765 chr5:72125136 TNPO1 -0.43 -5.4 -0.32 1.45e-7 Small cell lung carcinoma; CESC cis rs7851660 0.844 rs907581 chr9:100622189 A/G cg13688889 chr9:100608707 NA -0.64 -8.89 -0.48 9.61e-17 Strep throat; CESC cis rs7917772 0.503 rs2031601 chr10:104308064 T/G ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.38 0.31 1.64e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2120019 0.938 rs8030089 chr15:75290377 C/T cg09165964 chr15:75287851 SCAMP5 -0.78 -9.78 -0.52 1.69e-19 Blood trace element (Zn levels); CESC cis rs12900413 0.603 rs12911871 chr15:90301429 T/C cg24249390 chr15:90295951 MESP1 -0.4 -5.4 -0.31 1.52e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs798554 0.567 rs1182190 chr7:2869391 A/G cg19717773 chr7:2847554 GNA12 -0.39 -5.82 -0.34 1.72e-8 Height; CESC cis rs7312933 0.558 rs11181483 chr12:42798384 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.4 0.37 7.18e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg24549020 chr5:56110836 MAP3K1 0.68 7.71 0.43 2.61e-13 Initial pursuit acceleration; CESC cis rs6598955 0.543 rs57564009 chr1:26557618 A/T cg04990556 chr1:26633338 UBXN11 0.83 9.31 0.5 4.92e-18 Obesity-related traits; CESC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg05332525 chr7:65337924 VKORC1L1 -0.52 -6.42 -0.37 6.27e-10 Calcium levels; CESC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.45 0.46 2e-15 Menopause (age at onset); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26162020 chr7:48964031 CDC14C -0.46 -6.41 -0.37 6.6e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7524258 0.900 rs6577425 chr1:7306338 G/T cg07173049 chr1:7289937 CAMTA1 0.35 5.45 0.32 1.17e-7 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs3796352 1.000 rs11710292 chr3:53117798 T/C cg07884673 chr3:53033167 SFMBT1 0.66 5.57 0.32 6.4e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs6088580 0.524 rs2889855 chr20:33276853 A/G cg08999081 chr20:33150536 PIGU -0.43 -6.27 -0.36 1.43e-9 Glomerular filtration rate (creatinine); CESC cis rs9549367 0.737 rs11619691 chr13:113904636 T/C cg18105134 chr13:113819100 PROZ -0.68 -8.25 -0.45 7.53e-15 Platelet distribution width; CESC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg06108461 chr20:60628389 TAF4 -0.92 -14.55 -0.67 1.22e-35 Body mass index; CESC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg23758822 chr17:41437982 NA 0.98 16.37 0.71 4.38e-42 Menopause (age at onset); CESC cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg09021430 chr5:549028 NA -0.43 -5.41 -0.32 1.43e-7 Lung disease severity in cystic fibrosis; CESC cis rs11122272 0.735 rs2355872 chr1:231478489 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.45 -6.03 -0.35 5.36e-9 Hemoglobin concentration; CESC cis rs2777491 0.915 rs16971767 chr15:41623308 T/C cg18705301 chr15:41695430 NDUFAF1 -0.61 -9.27 -0.49 6.62e-18 Ulcerative colitis; CESC cis rs9790314 1.000 rs460508 chr3:161091089 C/G cg04691961 chr3:161091175 C3orf57 0.44 5.94 0.34 8.8e-9 Morning vs. evening chronotype; CESC trans rs2898290 0.622 rs1478890 chr8:11355602 C/G cg15556689 chr8:8085844 FLJ10661 -0.49 -6.04 -0.35 5.1e-9 Systolic blood pressure; CESC cis rs12410462 1.000 rs1587158 chr1:227658753 G/A cg04117972 chr1:227635322 NA -0.62 -6.2 -0.36 2.11e-9 Major depressive disorder; CESC cis rs6714710 0.603 rs11691494 chr2:98419726 T/A cg26665480 chr2:98280029 ACTR1B 0.57 8.07 0.44 2.42e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs2228479 0.850 rs2238525 chr16:89809902 T/C cg06558623 chr16:89946397 TCF25 0.89 7.99 0.44 4.18e-14 Skin colour saturation; CESC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg18876405 chr7:65276391 NA 0.49 6.28 0.36 1.37e-9 Calcium levels; CESC cis rs1023500 0.505 rs134889 chr22:42674350 A/T cg05082376 chr22:42548792 NA -0.38 -5.55 -0.32 7.01e-8 Schizophrenia; CESC cis rs651907 0.557 rs34181125 chr3:101490278 A/G cg12386194 chr3:101231763 SENP7 0.4 5.04 0.3 8.72e-7 Colorectal cancer; CESC cis rs662064 0.963 rs636291 chr1:10556097 G/A cg20482658 chr1:10539492 PEX14 -0.34 -6.85 -0.39 5.12e-11 Asthma; CESC cis rs2777491 0.915 rs7165675 chr15:41614704 T/C cg18705301 chr15:41695430 NDUFAF1 -0.6 -8.84 -0.48 1.39e-16 Ulcerative colitis; CESC cis rs637571 0.780 rs677029 chr11:65683531 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.55 6.7 0.38 1.21e-10 Eosinophil percentage of white cells; CESC cis rs2880765 0.835 rs4340287 chr15:86043737 A/G cg10818794 chr15:86012489 AKAP13 -0.34 -5.2 -0.3 4.03e-7 Coronary artery disease; CESC cis rs367943 0.712 rs9326889 chr5:112731438 A/G cg12552261 chr5:112820674 MCC 0.39 5.25 0.31 3.18e-7 Type 2 diabetes; CESC cis rs10744422 1.000 rs10744422 chr12:123336789 T/C cg22842854 chr12:123319900 HIP1R -0.67 -5.23 -0.31 3.5e-7 Schizophrenia; CESC cis rs765787 0.505 rs12593605 chr15:45497448 T/A cg24006582 chr15:45444508 DUOX1 0.53 6.27 0.36 1.44e-9 Uric acid levels; CESC cis rs1499972 0.564 rs62264773 chr3:117647875 G/A cg07612923 chr3:117604196 NA 0.69 6.15 0.35 2.83e-9 Schizophrenia; CESC trans rs11098499 0.908 rs11098527 chr4:120399906 A/G cg25214090 chr10:38739885 LOC399744 0.71 9.97 0.52 4.49e-20 Corneal astigmatism; CESC cis rs7647973 0.588 rs9883000 chr3:49667691 A/G cg07636037 chr3:49044803 WDR6 0.51 5.98 0.34 7.36e-9 Menarche (age at onset); CESC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg18357526 chr6:26021779 HIST1H4A 0.49 6.18 0.35 2.4e-9 Intelligence (multi-trait analysis); CESC trans rs11039798 0.588 rs584899 chr11:48431408 T/C cg15704280 chr7:45808275 SEPT13 -0.62 -6.25 -0.36 1.63e-9 Axial length; CESC cis rs7824557 0.527 rs57629785 chr8:11235150 C/A cg21775007 chr8:11205619 TDH -0.53 -7.87 -0.44 8.89e-14 Retinal vascular caliber; CESC cis rs1879734 0.731 rs61184814 chr1:54160709 G/T cg23596471 chr1:54105337 GLIS1 0.35 5.56 0.32 6.52e-8 Mitral valve prolapse; CESC cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg16240275 chr20:61666158 NCRNA00029 0.5 8.87 0.48 1.12e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs4568518 0.530 rs4721674 chr7:17993377 A/T cg03009463 chr7:17980271 SNX13 0.45 5.88 0.34 1.21e-8 Measles; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10315922 chr12:66563928 TMBIM4 0.45 6.46 0.37 4.89e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg20203395 chr5:56204925 C5orf35 -0.49 -5.78 -0.33 2.09e-8 Initial pursuit acceleration; CESC cis rs4722166 0.604 rs2390715 chr7:22783878 A/C cg05472934 chr7:22766657 IL6 0.86 10.87 0.56 5.47e-23 Lung cancer; CESC cis rs2228479 0.867 rs76885005 chr16:89966668 A/G cg00800038 chr16:89945340 TCF25 -0.85 -7.67 -0.43 3.2e-13 Skin colour saturation; CESC cis rs7216064 1.000 rs62084251 chr17:65878736 G/A cg07042672 chr17:66097459 LOC651250 -0.52 -5.4 -0.31 1.5e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.83 -9.11 -0.49 2.11e-17 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00291661 chr16:30581198 ZNF688 -0.61 -6.65 -0.38 1.71e-10 Gut microbiome composition (summer); CESC cis rs11718455 0.960 rs13060222 chr3:44005046 A/T cg08738300 chr3:44038990 NA 0.46 6.12 0.35 3.34e-9 Coronary artery disease; CESC cis rs6964587 1.000 rs7806157 chr7:91601930 A/G cg17063962 chr7:91808500 NA 0.54 7.21 0.4 6e-12 Breast cancer; CESC cis rs4803468 0.905 rs284662 chr19:41932275 T/C cg09537434 chr19:41945824 ATP5SL -1.14 -21.08 -0.79 1.31e-58 Height; CESC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg04287289 chr16:89883240 FANCA 0.9 15.16 0.68 8.38e-38 Vitiligo; CESC cis rs66573146 1.000 rs56178503 chr4:6961748 C/T cg00086871 chr4:6988644 TBC1D14 1.16 6.56 0.37 2.82e-10 Granulocyte percentage of myeloid white cells; CESC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg22535103 chr8:58192502 C8orf71 -1.04 -13.21 -0.63 5.76e-31 Developmental language disorder (linguistic errors); CESC cis rs73206853 0.764 rs28580853 chr12:110826209 C/G cg12870014 chr12:110450643 ANKRD13A 0.61 5.62 0.33 4.8e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs6723226 0.806 rs2249109 chr2:32750879 G/A cg02381751 chr2:32503542 YIPF4 0.86 12.44 0.61 2.81e-28 Intelligence (multi-trait analysis); CESC cis rs8099014 0.725 rs4998040 chr18:56093999 G/A cg12827950 chr18:55968429 NEDD4L -0.45 -5.06 -0.3 7.91e-7 Platelet count; CESC cis rs3857536 0.813 rs4710580 chr6:66935200 C/T cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs1670533 1.000 rs10084849 chr4:1053586 T/C cg27284194 chr4:1044797 NA 0.46 5.86 0.34 1.35e-8 Recombination rate (females); CESC cis rs9303401 0.659 rs35539277 chr17:56853833 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.99 11.34 0.57 1.51e-24 Cognitive test performance; CESC cis rs2832077 1.000 rs2832065 chr21:30135362 C/T cg03476357 chr21:30257390 N6AMT1 -0.48 -5.08 -0.3 7e-7 Cognitive test performance; CESC cis rs11098499 0.954 rs17009122 chr4:120362403 G/A cg24375607 chr4:120327624 NA 0.47 5.9 0.34 1.11e-8 Corneal astigmatism; CESC cis rs11166629 1.000 rs4909330 chr8:135644369 T/C cg27224718 chr8:135614730 ZFAT 0.5 6.37 0.36 8.2e-10 Smoking quantity; CESC cis rs258892 0.843 rs34455289 chr5:72053282 G/C cg21869765 chr5:72125136 TNPO1 -0.43 -5.36 -0.31 1.8e-7 Small cell lung carcinoma; CESC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg21782813 chr7:2030301 MAD1L1 0.45 6.34 0.36 1.01e-9 Bipolar disorder and schizophrenia; CESC cis rs13191362 0.872 rs35672319 chr6:163245464 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.64 6.3 0.36 1.22e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6977660 0.507 rs72591449 chr7:19775443 T/C cg05791153 chr7:19748676 TWISTNB 0.75 6.79 0.38 7.41e-11 Thyroid stimulating hormone; CESC cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11563648 0.535 rs1419395 chr7:126992598 T/C cg25922125 chr7:127225783 GCC1 -0.41 -5.03 -0.3 8.92e-7 Resting heart rate; CESC cis rs7590368 0.640 rs72779433 chr2:10946986 C/T cg15705551 chr2:10952987 PDIA6 0.55 5.26 0.31 2.99e-7 Educational attainment (years of education); CESC trans rs637571 0.607 rs589253 chr11:65693080 G/A cg17712092 chr4:129076599 LARP1B 0.79 10.8 0.55 8.7e-23 Eosinophil percentage of white cells; CESC cis rs7208859 0.673 rs2470251 chr17:29095061 T/C cg13385521 chr17:29058706 SUZ12P 0.59 5.54 0.32 7.29e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs644799 1.000 rs560854 chr11:95584905 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.22 0.36 1.98e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6460942 0.597 rs6944517 chr7:12515283 C/T cg02935154 chr7:12443704 VWDE -0.48 -5.09 -0.3 6.85e-7 Coronary artery disease; CESC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg09323728 chr8:95962352 TP53INP1 -0.39 -8.53 -0.46 1.11e-15 Type 2 diabetes; CESC cis rs4975616 0.869 rs370348 chr5:1331219 A/G cg26373071 chr5:1325741 CLPTM1L 0.43 6.92 0.39 3.37e-11 Lung cancer; CESC cis rs3862260 0.509 rs3795662 chr1:120165135 G/T cg11530693 chr1:120165357 ZNF697 0.69 10.58 0.55 4.58e-22 Systemic lupus erythematosus; CESC cis rs55871839 0.708 rs4738732 chr8:59809943 A/G cg07426533 chr8:59803705 TOX 0.47 6.94 0.39 3.04e-11 Pneumonia; CESC cis rs5753037 0.585 rs249401 chr22:30216168 C/T cg01021169 chr22:30184971 ASCC2 -0.56 -8.33 -0.46 4.35e-15 Type 1 diabetes; CESC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg18404041 chr3:52824283 ITIH1 -0.37 -6.3 -0.36 1.26e-9 Bipolar disorder; CESC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg04414720 chr1:150670196 GOLPH3L 0.5 6.46 0.37 5.04e-10 Melanoma; CESC cis rs2074585 0.560 rs12903058 chr15:91061121 G/T cg22089800 chr15:90895588 ZNF774 -0.5 -6.18 -0.35 2.44e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs11997175 0.624 rs79944133 chr8:33730588 A/G ch.8.33884649F chr8:33765107 NA 0.49 6.18 0.36 2.35e-9 Body mass index; CESC cis rs6582630 0.502 rs3902522 chr12:38271203 T/C cg26384229 chr12:38710491 ALG10B 0.65 9.03 0.49 3.55e-17 Drug-induced liver injury (flucloxacillin); CESC cis rs2880765 0.710 rs11630457 chr15:86004801 T/C cg10818794 chr15:86012489 AKAP13 -0.33 -5.06 -0.3 7.66e-7 Coronary artery disease; CESC cis rs6467136 0.765 rs4731370 chr7:127210207 G/A cg25922125 chr7:127225783 GCC1 -0.37 -5.07 -0.3 7.53e-7 Type 2 diabetes; CESC cis rs472109 0.565 rs360141 chr11:9784978 C/T cg03108697 chr11:9732066 SWAP70 -0.36 -5.15 -0.3 5.18e-7 Coronary artery disease; CESC cis rs7508679 1.000 rs4804411 chr19:7222377 G/C cg00428638 chr19:7224713 INSR 0.47 7.4 0.41 1.75e-12 Hypothyroidism; CESC cis rs60154123 0.615 rs701943 chr1:210425727 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 -0.56 -6.42 -0.37 6.43e-10 Coronary artery disease; CESC cis rs7953249 0.656 rs1732391 chr12:121392341 C/T cg25281562 chr12:121454272 C12orf43 -0.46 -5.77 -0.33 2.18e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg11752832 chr7:134001865 SLC35B4 0.52 6.79 0.38 7.4e-11 Mean platelet volume; CESC cis rs599083 0.569 rs685095 chr11:68170376 C/T cg01657329 chr11:68192670 LRP5 0.45 5.12 0.3 5.76e-7 Bone mineral density (spine); CESC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg03452623 chr4:187889614 NA -0.88 -16.16 -0.7 2.39e-41 Lobe attachment (rater-scored or self-reported); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg20015168 chr14:57046681 C14orf101 -0.47 -6.14 -0.35 3.02e-9 Recombination measurement; CESC cis rs2535633 0.631 rs6799185 chr3:53101580 C/T cg07507251 chr3:52567010 NT5DC2 0.32 5.11 0.3 6.31e-7 Body mass index; CESC cis rs7527798 0.571 rs7531923 chr1:207833336 T/G cg21110645 chr1:207815933 NA -0.34 -5.88 -0.34 1.26e-8 Erythrocyte sedimentation rate; CESC cis rs1348850 0.958 rs11689550 chr2:178456298 A/G cg23306229 chr2:178417860 TTC30B 0.47 5.8 0.34 1.85e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9814567 1.000 rs9851441 chr3:134315091 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.41 -5.56 -0.32 6.73e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4561483 0.801 rs33623 chr16:12007435 A/G cg08843971 chr16:11963173 GSPT1 0.54 7.97 0.44 4.76e-14 Testicular germ cell tumor; CESC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.5 -6.67 -0.38 1.5e-10 Menarche (age at onset); CESC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg11843238 chr5:131593191 PDLIM4 0.37 5.36 0.31 1.8e-7 Breast cancer; CESC cis rs9911578 0.704 rs72628393 chr17:56585314 A/T cg10487724 chr17:56770010 TEX14;RAD51C -0.41 -5.45 -0.32 1.18e-7 Intelligence (multi-trait analysis); CESC cis rs7918232 0.627 rs6482588 chr10:27308307 G/C cg14240646 chr10:27532245 ACBD5 -0.51 -5.41 -0.32 1.44e-7 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05671585 chr4:186064123 SLC25A4 -0.47 -6.06 -0.35 4.79e-9 Fibrinogen levels; CESC cis rs7084402 0.967 rs11006171 chr10:60278487 C/T cg07615347 chr10:60278583 BICC1 -0.57 -8.75 -0.47 2.54e-16 Refractive error; CESC cis rs9911578 1.000 rs2055779 chr17:57030561 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.39e-11 Intelligence (multi-trait analysis); CESC cis rs2243480 1.000 rs7792391 chr7:65773429 A/G cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14774160 chr17:4901081 INCA1;KIF1C 0.53 6.24 0.36 1.73e-9 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs9911784 chr17:29124580 A/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17182302 chr1:116961525 C1orf203 0.58 6.61 0.38 2.1e-10 Gut microbiome composition (summer); CESC cis rs2637266 0.703 rs1561676 chr10:78459211 T/C cg18941641 chr10:78392320 NA 0.39 6.9 0.39 3.74e-11 Pulmonary function; CESC cis rs709400 0.588 rs61996718 chr14:104048834 G/A cg12935359 chr14:103987150 CKB -0.55 -6.24 -0.36 1.71e-9 Body mass index; CESC cis rs7799006 0.606 rs34417375 chr7:2315105 C/T cg08027265 chr7:2291960 NA -0.58 -9.91 -0.52 6.83e-20 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4853012 0.887 rs6737314 chr2:74339586 A/G cg05890377 chr2:74357713 NA 0.58 7.03 0.4 1.8e-11 Gestational age at birth (maternal effect); CESC cis rs977987 0.806 rs35552529 chr16:75405879 G/C cg03315344 chr16:75512273 CHST6 0.4 5.68 0.33 3.59e-8 Dupuytren's disease; CESC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg08704250 chr15:31115839 NA -0.63 -8.12 -0.45 1.8e-14 Huntington's disease progression; CESC cis rs9300255 0.596 rs10734901 chr12:123743447 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.03 -0.3 9.21e-7 Neutrophil percentage of white cells; CESC cis rs9486715 0.793 rs2499777 chr6:97013814 T/C cg06623918 chr6:96969491 KIAA0776 -0.95 -15.1 -0.68 1.35e-37 Headache; CESC cis rs5758511 0.680 rs17002902 chr22:42625509 C/G cg00645731 chr22:42541494 CYP2D7P1 0.58 8.64 0.47 5.43e-16 Birth weight; CESC cis rs3816788 0.792 rs7013323 chr8:21869024 C/G cg17168535 chr8:21777572 XPO7 0.58 8.26 0.45 6.93e-15 Lung cancer in ever smokers; CESC trans rs9650657 0.537 rs4841457 chr8:10773511 T/G cg15556689 chr8:8085844 FLJ10661 -0.59 -7.46 -0.42 1.23e-12 Neuroticism; CESC cis rs2243480 1.000 rs4149468 chr7:65825690 T/C cg13147721 chr7:65941812 NA -0.96 -9.02 -0.48 3.92e-17 Diabetic kidney disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18708365 chr7:103848079 ORC5L -0.43 -6.14 -0.35 3.02e-9 Gut microbiota (bacterial taxa); CESC cis rs2197308 0.606 rs2218397 chr12:38278307 C/T cg26384229 chr12:38710491 ALG10B -0.43 -5.65 -0.33 4.09e-8 Morning vs. evening chronotype; CESC cis rs6088580 0.634 rs7271970 chr20:32987666 A/G cg08999081 chr20:33150536 PIGU -0.64 -11.17 -0.57 5.54e-24 Glomerular filtration rate (creatinine); CESC cis rs7845219 0.544 rs9643352 chr8:95918288 C/T cg16049864 chr8:95962084 TP53INP1 -0.49 -7.22 -0.41 5.48e-12 Type 2 diabetes; CESC cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg18904891 chr8:8559673 CLDN23 0.65 7.8 0.43 1.4e-13 Obesity-related traits; CESC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg18230493 chr5:56204884 C5orf35 -0.73 -8.57 -0.47 8.93e-16 Initial pursuit acceleration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24108215 chr1:39174820 NA 0.4 6.48 0.37 4.53e-10 Gambling; CESC cis rs72781680 0.821 rs55948613 chr2:24094787 A/G cg08917208 chr2:24149416 ATAD2B 0.58 5.81 0.34 1.82e-8 Lymphocyte counts; CESC cis rs10870270 0.956 rs7894 chr10:133769482 G/C cg17892150 chr10:133769511 PPP2R2D -0.86 -12.54 -0.61 1.28e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs8067545 0.611 rs2703814 chr17:20117151 T/C cg13482628 chr17:19912719 NA -0.43 -5.81 -0.34 1.81e-8 Schizophrenia; CESC cis rs9623117 0.915 rs9611262 chr22:40475587 A/T cg05033341 chr22:40419857 FAM83F -0.49 -5.49 -0.32 9.61e-8 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg11657440 chr19:46296263 DMWD 0.77 11.86 0.59 2.54e-26 Coronary artery disease; CESC cis rs9788682 0.894 rs4461039 chr15:78817447 A/T cg24631222 chr15:78858424 CHRNA5 -0.72 -9.41 -0.5 2.42e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs34779708 0.931 rs35136660 chr10:35385973 C/A cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs4481887 1.000 rs4554750 chr1:248496530 C/G cg00666640 chr1:248458726 OR2T12 0.41 6.6 0.38 2.21e-10 Common traits (Other); CESC cis rs965469 1.000 rs2092990 chr20:3346338 C/T cg25506879 chr20:3388711 C20orf194 -0.55 -5.85 -0.34 1.43e-8 IFN-related cytopenia; CESC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg18876405 chr7:65276391 NA -0.51 -6.73 -0.38 1.05e-10 Aortic root size; CESC cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg22834771 chr12:69754056 YEATS4 -0.48 -6.46 -0.37 4.87e-10 Blood protein levels; CESC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg08859206 chr1:53392774 SCP2 0.59 7.72 0.43 2.37e-13 Monocyte count; CESC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg04944784 chr2:26401820 FAM59B -0.66 -7.58 -0.42 5.83e-13 Gut microbiome composition (summer); CESC cis rs4243830 0.737 rs11122091 chr1:6609559 C/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.82 -8.84 -0.48 1.4e-16 Body mass index; CESC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg11764359 chr7:65958608 NA 0.73 10.6 0.55 4.14e-22 Aortic root size; CESC cis rs2880765 0.566 rs11630381 chr15:86012503 A/G cg19183879 chr15:85880815 NA -0.31 -5.9 -0.34 1.12e-8 Coronary artery disease; CESC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg19774624 chr17:42201019 HDAC5 -0.75 -11.07 -0.56 1.19e-23 Total body bone mineral density; CESC cis rs7818688 1.000 rs7008542 chr8:96027863 C/A cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7937682 0.562 rs527847 chr11:111369132 A/C cg09085632 chr11:111637200 PPP2R1B 0.65 8.84 0.48 1.36e-16 Primary sclerosing cholangitis; CESC cis rs79149102 0.579 rs12593476 chr15:75282092 A/C cg18866210 chr15:74343476 NA 0.53 5.41 0.32 1.42e-7 Lung cancer; CESC cis rs798766 1.000 rs798756 chr4:1707447 T/C cg05874882 chr4:1763078 NA -0.56 -7.39 -0.41 1.88e-12 Bladder cancer;Urinary bladder cancer; CESC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg11764359 chr7:65958608 NA 0.8 10.13 0.53 1.35e-20 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14797243 chr11:68671428 IGHMBP2;MRPL21 0.58 7.6 0.42 5.18e-13 Gut microbiota (bacterial taxa); CESC cis rs7216064 0.953 rs2086744 chr17:65849275 C/G cg07042672 chr17:66097459 LOC651250 -0.53 -5.57 -0.32 6.1e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6952809 0.532 rs2057840 chr7:2432797 C/G cg23289794 chr7:2394357 EIF3B -0.67 -6.78 -0.38 7.56e-11 Multiple sclerosis; CESC cis rs6087990 0.806 rs875041 chr20:31383530 C/T cg13636640 chr20:31349939 DNMT3B 0.83 13.59 0.64 2.77e-32 Ulcerative colitis; CESC cis rs2717559 0.561 rs7841267 chr8:143881683 A/C cg17252645 chr8:143867129 LY6D -0.33 -5.59 -0.32 5.64e-8 Urinary tract infection frequency; CESC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg25767906 chr1:53392781 SCP2 -0.44 -5.63 -0.33 4.57e-8 Monocyte count; CESC cis rs6750795 0.502 rs11685196 chr2:232381298 A/G cg19187155 chr2:232395269 NMUR1 0.47 7.84 0.43 1.1e-13 Height; CESC cis rs9911578 1.000 rs3744109 chr17:56594197 C/T cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.5e-11 Intelligence (multi-trait analysis); CESC cis rs12410462 0.748 rs1495853 chr1:227657336 A/G cg04117972 chr1:227635322 NA -0.62 -6.2 -0.36 2.11e-9 Major depressive disorder; CESC cis rs763121 0.853 rs5757141 chr22:38957483 G/A cg06022373 chr22:39101656 GTPBP1 0.81 11.55 0.58 2.87e-25 Menopause (age at onset); CESC cis rs1729951 0.546 rs12054408 chr3:136677645 T/C cg03617693 chr3:136751559 NA 0.38 5.31 0.31 2.27e-7 Neuroticism; CESC cis rs6687430 0.526 rs12120962 chr1:10609505 G/A cg07384165 chr1:10488281 NA -0.48 -6.55 -0.37 3.02e-10 Hand grip strength; CESC cis rs6723226 0.650 rs6729952 chr2:32764922 T/C cg02381751 chr2:32503542 YIPF4 0.7 9.57 0.51 7.76e-19 Intelligence (multi-trait analysis); CESC cis rs9323205 0.954 rs4258524 chr14:51638739 A/T cg23942311 chr14:51606299 NA -0.42 -5.77 -0.33 2.25e-8 Cancer; CESC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg06481639 chr22:41940642 POLR3H -0.62 -6.5 -0.37 4.04e-10 Vitiligo; CESC cis rs2635047 0.684 rs7236105 chr18:44757226 G/T cg24371990 chr18:44770781 NA 0.4 6.48 0.37 4.33e-10 Educational attainment; CESC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.93e-7 Lung cancer; CESC cis rs6740322 0.841 rs10210507 chr2:43556636 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.7 -7.37 -0.41 2.12e-12 Coronary artery disease; CESC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg18337363 chr3:52569053 NT5DC2 0.29 5.28 0.31 2.66e-7 Bipolar disorder; CESC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg12034118 chr1:209979487 IRF6 0.41 5.07 0.3 7.59e-7 Cleft lip with or without cleft palate; CESC cis rs11785400 0.701 rs9297968 chr8:143723009 A/G cg10596483 chr8:143751796 JRK 0.4 5.14 0.3 5.32e-7 Schizophrenia; CESC trans rs61931739 0.534 rs12372721 chr12:34175301 C/T cg26384229 chr12:38710491 ALG10B 0.66 9.12 0.49 1.89e-17 Morning vs. evening chronotype; CESC cis rs2425143 1.000 rs11696369 chr20:34378629 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.72 6.65 0.38 1.63e-10 Blood protein levels; CESC cis rs9486715 0.867 rs2499775 chr6:97007340 C/T cg18709589 chr6:96969512 KIAA0776 -0.47 -6.56 -0.37 2.86e-10 Headache; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16238933 chr4:668052 ATP5I -0.5 -6.29 -0.36 1.29e-9 Fibrinogen levels; CESC cis rs7116495 0.609 rs7113436 chr11:71689599 A/T cg18441811 chr11:71824068 C11orf51 0.89 5.39 0.31 1.59e-7 Severe influenza A (H1N1) infection; CESC cis rs2288073 0.801 rs2384008 chr2:24373150 A/G cg20701182 chr2:24300061 SF3B14 0.47 5.92 0.34 9.9e-9 Venous thromboembolism (SNP x SNP interaction); CESC cis rs7167736 0.637 rs1689939 chr15:101205180 C/T cg09499109 chr15:101097659 NA 0.4 5.06 0.3 7.97e-7 Chin dimples; CESC cis rs3126085 1.000 rs11204971 chr1:152259078 A/G cg03465714 chr1:152285911 FLG 0.49 5.43 0.32 1.24e-7 Atopic dermatitis; CESC cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg18876405 chr7:65276391 NA 0.46 5.24 0.31 3.3e-7 Aortic root size; CESC cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.16 0.3 4.85e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.653 rs11182569 chr12:38572452 G/A cg26384229 chr12:38710491 ALG10B 0.76 11.48 0.58 4.84e-25 Bladder cancer; CESC cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.07 0.3 7.32e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs60154123 0.505 rs2206043 chr1:210042983 G/A cg23283495 chr1:209979779 IRF6 0.52 5.85 0.34 1.42e-8 Coronary artery disease; CESC cis rs7089973 0.668 rs61868024 chr10:116637939 A/G cg25233709 chr10:116636983 FAM160B1 0.4 6.24 0.36 1.7e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -5.61 -0.33 5.07e-8 Extrinsic epigenetic age acceleration; CESC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.37 -6.01 -0.35 6.26e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9522267 0.502 rs9522281 chr13:112222389 G/A cg10483660 chr13:112241077 NA -0.33 -5.79 -0.34 1.94e-8 Hepatitis; CESC cis rs921968 0.509 rs10932782 chr2:219353195 C/T cg02176678 chr2:219576539 TTLL4 0.5 8.98 0.48 5.22e-17 Mean corpuscular hemoglobin concentration; CESC cis rs10504229 0.871 rs16921952 chr8:58163317 A/T cg05313129 chr8:58192883 C8orf71 -0.44 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs7964748 0.769 rs73179274 chr12:103024937 C/T cg02806658 chr12:102513592 C12orf48;NUP37 -0.57 -5.07 -0.3 7.56e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg12386194 chr3:101231763 SENP7 0.57 6.55 0.37 3e-10 Colonoscopy-negative controls vs population controls; CESC cis rs4975616 0.804 rs462608 chr5:1336626 T/A cg26373071 chr5:1325741 CLPTM1L 0.45 7.17 0.4 7.32e-12 Lung cancer; CESC cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg23711669 chr6:146136114 FBXO30 0.84 10.88 0.56 5.04e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs3749237 0.595 rs4855839 chr3:49507847 G/A cg03060546 chr3:49711283 APEH 0.77 11.58 0.58 2.22e-25 Resting heart rate; CESC cis rs1569019 0.790 rs11613786 chr12:131581429 C/T cg16379671 chr12:131647826 NA -0.64 -5.07 -0.3 7.61e-7 Height; CESC cis rs300703 0.935 rs12714403 chr2:273070 A/G cg21211680 chr2:198530 NA 0.91 7.67 0.43 3.27e-13 Blood protein levels; CESC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.89 0.39 4.13e-11 Bipolar disorder; CESC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg11301795 chr4:187892539 NA -0.75 -12.51 -0.61 1.63e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs8114671 0.562 rs6088635 chr20:33466501 A/G cg07148914 chr20:33460835 GGT7 0.51 6.76 0.38 8.89e-11 Height; CESC cis rs2299587 0.554 rs3853530 chr8:17748420 C/T cg08627089 chr8:17753878 FGL1 -0.41 -5.89 -0.34 1.15e-8 Economic and political preferences; CESC cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg25204440 chr1:209979598 IRF6 0.59 5.92 0.34 9.82e-9 Cleft lip with or without cleft palate; CESC cis rs7662987 0.517 rs2602866 chr4:100034997 A/G cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC cis rs4268898 0.862 rs11125549 chr2:24576240 C/T cg06627628 chr2:24431161 ITSN2 0.71 8.57 0.47 8.46e-16 Asthma; CESC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.18 0.36 2.36e-9 Bipolar disorder; CESC cis rs589448 0.538 rs683790 chr12:69751434 T/G cg14784868 chr12:69753453 YEATS4 0.73 9.43 0.5 2.22e-18 Cerebrospinal fluid biomarker levels; CESC cis rs9611565 0.513 rs739135 chr22:42090069 A/C cg06481639 chr22:41940642 POLR3H 0.59 5.91 0.34 1.05e-8 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03304714 chr17:57297813 GDPD1 0.59 6.41 0.37 6.62e-10 Gut microbiome composition (summer); CESC cis rs4555082 0.874 rs1882846 chr14:105717448 G/C cg13114125 chr14:105738426 BRF1 -0.82 -10.07 -0.53 2.04e-20 Mean platelet volume;Platelet distribution width; CESC cis rs2380220 1.000 rs2380220 chr6:95967412 T/C cg15832292 chr6:96025679 MANEA 0.62 5.72 0.33 2.84e-8 Behavioural disinhibition (generation interaction); CESC cis rs7762018 1.000 rs11961560 chr6:170130121 T/C cg05834625 chr6:170176447 C6orf70 0.66 7.86 0.43 9.48e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs765787 0.530 rs10851423 chr15:45515950 G/A cg24006582 chr15:45444508 DUOX1 0.52 6.25 0.36 1.61e-9 Uric acid levels; CESC cis rs11785400 1.000 rs4327844 chr8:143733540 C/T cg10596483 chr8:143751796 JRK -0.42 -5.56 -0.32 6.54e-8 Schizophrenia; CESC cis rs174775 0.513 rs3788411 chr22:29728783 T/C cg07256473 chr22:29710276 RASL10A -0.47 -7.23 -0.41 5.04e-12 Immature fraction of reticulocytes; CESC cis rs10189230 0.967 rs13012331 chr2:222350600 G/A cg14652038 chr2:222343519 EPHA4 0.36 7.46 0.42 1.24e-12 Urate levels in lean individuals; CESC cis rs73206853 0.841 rs73191818 chr12:110918721 T/G cg12870014 chr12:110450643 ANKRD13A 0.63 5.22 0.31 3.56e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs4835473 0.932 rs1838516 chr4:144883235 A/C cg25736465 chr4:144833511 NA 0.41 6.11 0.35 3.59e-9 Immature fraction of reticulocytes; CESC cis rs4604732 0.588 rs7552443 chr1:247628583 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.09 0.3 6.91e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4662945 0.603 rs10168574 chr2:130267823 C/T cg05903289 chr2:130345205 NA -0.43 -6.34 -0.36 9.83e-10 Response to cytidine analogues (gemcitabine); CESC cis rs738322 0.967 rs133017 chr22:38572637 A/C cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg04944784 chr2:26401820 FAM59B 0.96 10.83 0.55 7.34e-23 Gut microbiome composition (summer); CESC cis rs59918340 0.764 rs9324542 chr8:142227854 A/T cg23750338 chr8:142222470 SLC45A4 -0.58 -8.5 -0.46 1.38e-15 Immature fraction of reticulocytes; CESC cis rs7903847 0.620 rs9787454 chr10:99155561 A/T cg20016023 chr10:99160130 RRP12 -0.3 -5.16 -0.3 4.77e-7 Granulocyte percentage of myeloid white cells; CESC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.71 11.38 0.57 1.04e-24 Personality dimensions; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00491963 chr11:57335356 UBE2L6 -0.43 -6.14 -0.35 3.02e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9303401 0.614 rs3887355 chr17:56538639 T/C cg25039879 chr17:56429692 SUPT4H1 0.53 5.39 0.31 1.55e-7 Cognitive test performance; CESC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg14393609 chr7:65229607 NA 0.52 7.09 0.4 1.19e-11 Calcium levels; CESC cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg15605315 chr1:45957053 TESK2 0.5 6.63 0.38 1.83e-10 High light scatter reticulocyte count; CESC cis rs6831352 0.851 rs1230164 chr4:99986023 C/G cg12011299 chr4:100065546 ADH4 0.61 6.92 0.39 3.35e-11 Alcohol dependence; CESC cis rs9768139 0.935 rs7800718 chr7:158121878 G/A cg24154853 chr7:158122151 PTPRN2 -0.41 -6.51 -0.37 3.79e-10 Calcium levels; CESC cis rs868036 1.000 rs1471460 chr15:68089299 G/A cg08079166 chr15:68083412 MAP2K5 0.45 7.05 0.4 1.53e-11 Restless legs syndrome; CESC cis rs9457247 0.565 rs2239823 chr6:167512131 T/C cg07741184 chr6:167504864 NA 0.43 7.65 0.43 3.84e-13 Crohn's disease; CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg05564831 chr3:52568323 NT5DC2 0.54 9.53 0.51 1.05e-18 Electroencephalogram traits; CESC cis rs9910055 0.529 rs408282 chr17:42182267 A/G cg08499158 chr17:42289980 UBTF 0.43 5.13 0.3 5.72e-7 Total body bone mineral density; CESC cis rs718433 0.584 rs8015812 chr14:22215075 C/T cg02257791 chr14:22217085 NA -0.32 -5.03 -0.3 9.07e-7 Intraocular pressure; CESC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg21963583 chr11:68658836 MRPL21 -0.36 -5.32 -0.31 2.26e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6831352 0.918 rs1126672 chr4:100047812 G/A cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg04234412 chr22:24373322 LOC391322 0.51 7.36 0.41 2.31e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg03709012 chr19:19516395 GATAD2A 1.01 15.76 0.7 6.12e-40 Tonsillectomy; CESC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 10.1 0.53 1.71e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11252926 0.527 rs10904093 chr10:436848 A/G cg16386425 chr10:429943 DIP2C 0.51 6.51 0.37 3.7e-10 Psychosis in Alzheimer's disease; CESC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC trans rs4756846 0.810 rs78219844 chr11:16459304 A/T cg05579622 chr5:10618622 ANKRD33B 0.72 6.55 0.37 2.99e-10 Obesity and osteoporosis; CESC cis rs2637266 0.538 rs11001860 chr10:78473388 G/T cg18941641 chr10:78392320 NA -0.33 -5.29 -0.31 2.54e-7 Pulmonary function; CESC cis rs3096299 0.606 rs2965946 chr16:89516612 T/C cg08845973 chr16:89592071 SPG7 -0.37 -5.07 -0.3 7.46e-7 Multiple myeloma (IgH translocation); CESC cis rs6061231 0.583 rs2427313 chr20:60970675 G/A cg15674680 chr20:60982522 CABLES2 0.49 5.89 0.34 1.18e-8 Colorectal cancer; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg12393716 chr11:62495049 TTC9C;HNRNPUL2 0.51 6.86 0.39 4.77e-11 Tetralogy of Fallot; CESC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg18337363 chr3:52569053 NT5DC2 0.28 5.2 0.3 3.94e-7 Bipolar disorder; CESC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg22903471 chr2:27725779 GCKR -0.5 -7.08 -0.4 1.32e-11 Menopause (age at onset); CESC cis rs7107174 1.000 rs10899491 chr11:78106305 T/C cg02023728 chr11:77925099 USP35 0.47 6.25 0.36 1.63e-9 Testicular germ cell tumor; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22939043 chr6:170059563 WDR27 0.51 6.66 0.38 1.53e-10 Fibrinogen levels; CESC cis rs6964587 0.843 rs56075286 chr7:91731518 G/A cg17063962 chr7:91808500 NA 0.55 7.49 0.42 1.06e-12 Breast cancer; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg24914313 chr13:41636195 WBP4 0.43 6.05 0.35 4.97e-9 Positive affect; CESC cis rs6752107 0.967 rs12162308 chr2:234172188 C/G cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.36 5.5 0.32 9.16e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs7520050 0.933 rs6680211 chr1:46315007 C/G cg03146154 chr1:46216737 IPP -0.48 -6.36 -0.36 8.91e-10 Red blood cell count;Reticulocyte count; CESC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.56 -7.83 -0.43 1.15e-13 Platelet count; CESC cis rs6580649 0.941 rs1018973 chr12:48441692 C/G cg24011408 chr12:48396354 COL2A1 0.42 5.37 0.31 1.7e-7 Lung cancer; CESC cis rs9611565 0.546 rs739134 chr22:42089623 T/C cg17376030 chr22:41985996 PMM1 -0.66 -7.16 -0.4 7.77e-12 Vitiligo; CESC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg10691866 chr7:65817282 TPST1 0.32 5.3 0.31 2.42e-7 Aortic root size; CESC cis rs7833986 0.501 rs2719261 chr8:56941982 C/G cg26371346 chr8:56986568 SNORD54;RPS20 0.59 5.49 0.32 9.26e-8 Height; CESC cis rs2228479 0.614 rs1137042 chr16:89975638 A/G cg00800038 chr16:89945340 TCF25 -0.53 -5.72 -0.33 2.95e-8 Skin colour saturation; CESC trans rs61931739 0.500 rs11053243 chr12:34514155 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.55 0.42 7.05e-13 Morning vs. evening chronotype; CESC trans rs875971 1.000 rs11974264 chr7:65647582 C/G cg26939375 chr7:64535504 NA -0.48 -6.37 -0.36 8.2e-10 Aortic root size; CESC cis rs4727963 0.792 rs6466853 chr7:122719094 C/A cg03640110 chr7:122635026 TAS2R16 -0.38 -5.89 -0.34 1.14e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs7208859 0.673 rs7211776 chr17:29120196 T/G cg14008862 chr17:28927542 LRRC37B2 0.57 5.43 0.32 1.3e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs950169 0.922 rs11630507 chr15:85095725 A/G cg17507749 chr15:85114479 UBE2QP1 0.57 6.37 0.36 8.53e-10 Schizophrenia; CESC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg10691866 chr7:65817282 TPST1 0.33 5.21 0.3 3.74e-7 Aortic root size; CESC cis rs7945705 0.869 rs4909952 chr11:8963946 A/G cg12365402 chr11:9010492 NRIP3 0.37 5.82 0.34 1.68e-8 Hemoglobin concentration; CESC cis rs1957429 0.808 rs4899150 chr14:65344400 A/G cg23373153 chr14:65346875 NA 1.02 10.46 0.54 1.15e-21 Pediatric areal bone mineral density (radius); CESC cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg16339924 chr4:17578868 LAP3 0.65 8.27 0.45 6.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg10792982 chr14:105748885 BRF1 0.4 5.65 0.33 4.21e-8 Mean platelet volume;Platelet distribution width; CESC cis rs763121 0.853 rs6001188 chr22:39062194 T/C cg21395723 chr22:39101663 GTPBP1 0.46 5.78 0.33 2.08e-8 Menopause (age at onset); CESC trans rs61931739 0.500 rs35030191 chr12:34548865 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC cis rs1957429 0.808 rs6573580 chr14:65331766 C/G cg23373153 chr14:65346875 NA 0.88 9.2 0.49 1.13e-17 Pediatric areal bone mineral density (radius); CESC cis rs798554 0.616 rs1636252 chr7:2884993 A/C cg19717773 chr7:2847554 GNA12 -0.48 -7.28 -0.41 3.7e-12 Height; CESC cis rs2040771 0.804 rs2073754 chr22:19221406 G/T cg02655711 chr22:19163373 SLC25A1 -0.4 -5.77 -0.33 2.23e-8 Metabolite levels (small molecules and protein measures); CESC cis rs6582630 0.502 rs10880388 chr12:38401341 A/T cg26384229 chr12:38710491 ALG10B 0.72 10.94 0.56 3.12e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs7772486 0.754 rs6921073 chr6:146144377 G/A cg23711669 chr6:146136114 FBXO30 0.89 13.07 0.63 1.87e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs7590720 1.000 rs6435930 chr2:216885852 A/G cg12620499 chr2:216877984 MREG 0.91 12.4 0.61 3.63e-28 Alcohol dependence; CESC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.51 0.8 4.47e-60 Prudent dietary pattern; CESC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg16325326 chr1:53192061 ZYG11B 0.91 16.16 0.7 2.32e-41 Monocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20119015 chr4:36245632 ARAP2 -0.38 -6.07 -0.35 4.34e-9 Gambling; CESC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg18876405 chr7:65276391 NA 0.44 6.06 0.35 4.76e-9 Aortic root size; CESC cis rs9326248 0.530 rs2000615 chr11:116915819 C/T cg01368799 chr11:117014884 PAFAH1B2 0.6 5.43 0.32 1.28e-7 Blood protein levels; CESC cis rs17407555 0.520 rs4292327 chr4:9943700 G/A cg11266682 chr4:10021025 SLC2A9 -0.51 -6.34 -0.36 9.88e-10 Schizophrenia (age at onset); CESC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg17328964 chr8:145687451 CYHR1 0.49 6.62 0.38 2.04e-10 Age at first birth; CESC cis rs6032067 0.929 rs35880287 chr20:43821001 G/A cg10761708 chr20:43804764 PI3 0.53 6.39 0.37 7.37e-10 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15030636 chr1:246768697 CNST -0.47 -6.03 -0.35 5.38e-9 Gut microbiome composition (summer); CESC cis rs1153858 1.000 rs1554521 chr15:45664189 A/T cg14582100 chr15:45693742 SPATA5L1 -0.41 -5.91 -0.34 1.07e-8 Homoarginine levels; CESC cis rs2635047 0.904 rs2635046 chr18:44728429 G/A cg24371990 chr18:44770781 NA 0.33 5.25 0.31 3.15e-7 Educational attainment; CESC cis rs8067354 0.574 rs7219089 chr17:58032865 C/T cg13753209 chr17:57696993 CLTC 0.53 5.59 0.32 5.61e-8 Hemoglobin concentration; CESC cis rs1665050 0.534 rs12900291 chr15:59240419 T/C cg05156742 chr15:59063176 FAM63B 0.5 6.42 0.37 6.18e-10 Atopic dermatitis; CESC cis rs72781680 0.611 rs72783625 chr2:24315540 C/T cg06627628 chr2:24431161 ITSN2 -0.68 -6.58 -0.37 2.44e-10 Lymphocyte counts; CESC cis rs6547741 1.000 rs6749052 chr2:27772879 A/T cg27432699 chr2:27873401 GPN1 0.49 6.82 0.39 6.33e-11 Oral cavity cancer; CESC cis rs820218 0.743 rs11652586 chr17:73690287 G/A cg01592526 chr17:73663357 RECQL5;SAP30BP -0.44 -6.03 -0.35 5.57e-9 Rotator cuff tears; CESC cis rs11864453 0.647 rs9941346 chr16:72135707 C/G cg01557791 chr16:72042693 DHODH -0.43 -5.63 -0.33 4.58e-8 Fibrinogen levels; CESC cis rs11229555 0.645 rs72917641 chr11:58227320 A/C cg15696309 chr11:58395628 NA -0.45 -5.22 -0.31 3.63e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20272604 chr1:231004631 C1orf198 0.6 6.89 0.39 4.15e-11 Gut microbiome composition (summer); CESC cis rs4727027 0.840 rs12670633 chr7:148796707 G/A cg23583168 chr7:148888333 NA -0.79 -12.1 -0.6 4.02e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs8002861 0.727 rs9533652 chr13:44419532 A/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.4 -5.26 -0.31 2.99e-7 Leprosy; CESC cis rs514406 0.893 rs1242315 chr1:53417181 A/G cg08736216 chr1:53307985 ZYG11A -0.41 -6.56 -0.37 2.85e-10 Monocyte count; CESC cis rs11098499 0.954 rs9993199 chr4:120392873 A/G cg09307838 chr4:120376055 NA -0.97 -14.58 -0.67 9.09e-36 Corneal astigmatism; CESC trans rs1814175 0.647 rs10769646 chr11:49992204 C/A cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg17644776 chr2:200775616 C2orf69 -0.52 -6.45 -0.37 5.2e-10 Osteoporosis; CESC cis rs9287719 0.967 rs715247 chr2:10736291 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs12142240 0.698 rs56909107 chr1:46808224 A/C cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22004443 chr2:10953237 PDIA6 -0.54 -6.37 -0.36 8.22e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16693872 chr5:176882643 PRR7 0.64 7.77 0.43 1.76e-13 Gut microbiome composition (summer); CESC cis rs2839186 0.585 rs2839154 chr21:47637760 C/T cg13126279 chr21:47581558 C21orf56 0.41 5.24 0.31 3.26e-7 Testicular germ cell tumor; CESC trans rs1829883 0.733 rs2461996 chr5:98721657 T/A cg23861655 chr4:57411219 NA 0.38 6.12 0.35 3.27e-9 Hemostatic factors and hematological phenotypes; CESC cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.97 9.3 0.5 5.47e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8064299 0.597 rs7210318 chr17:72783385 T/C cg25054828 chr17:72772726 NAT9;TMEM104 0.82 13.99 0.65 1.09e-33 Monocyte count; CESC cis rs2072732 0.861 rs6692292 chr1:2959610 C/T cg15211996 chr1:2936768 ACTRT2 -0.31 -5.38 -0.31 1.66e-7 Plateletcrit; CESC cis rs832540 0.806 rs10039322 chr5:56260259 A/C cg14703610 chr5:56206110 C5orf35 0.45 5.91 0.34 1.03e-8 Coronary artery disease; CESC cis rs501120 1.000 rs554565 chr10:44755448 G/A cg09554077 chr10:44749378 NA 0.54 7.1 0.4 1.14e-11 Coronary artery disease;Coronary heart disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10204999 chr14:103057895 RCOR1 0.53 6.26 0.36 1.51e-9 Gut microbiome composition (summer); CESC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg24675658 chr1:53192096 ZYG11B 0.54 6.8 0.39 6.96e-11 Monocyte count; CESC cis rs6570726 0.791 rs6570694 chr6:145911204 C/G cg23711669 chr6:146136114 FBXO30 0.92 13.58 0.64 3.16e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs6580649 0.941 rs1968071 chr12:48489357 A/G cg24011408 chr12:48396354 COL2A1 -0.41 -5.13 -0.3 5.73e-7 Lung cancer; CESC trans rs9944275 0.860 rs35862958 chr15:97192556 G/A cg26794346 chr6:16472305 ATXN1 0.75 6.1 0.35 3.64e-9 Depressive symptoms (multi-trait analysis);Neuroticism (multi-trait analysis); CESC trans rs17613427 1.000 rs112138076 chr2:142238491 G/A cg16810031 chr17:38024146 ZPBP2 -0.9 -6.22 -0.36 1.89e-9 Left ventricle systolic dysfunction; CESC cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg15017067 chr4:17643749 FAM184B 0.36 5.16 0.3 4.78e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11264213 0.901 rs72661625 chr1:36401003 T/C cg27506609 chr1:36549197 TEKT2 0.66 5.55 0.32 6.79e-8 Schizophrenia; CESC cis rs1559088 0.546 rs11881543 chr19:33559372 T/G cg03563238 chr19:33554763 RHPN2 -0.32 -5.8 -0.34 1.9e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2486288 0.656 rs2461705 chr15:45570241 A/G cg09092052 chr15:45571596 NA 0.51 5.96 0.34 8.16e-9 Glomerular filtration rate; CESC cis rs7824557 0.606 rs2736264 chr8:11186639 G/C cg21775007 chr8:11205619 TDH 0.5 7.23 0.41 5.21e-12 Retinal vascular caliber; CESC cis rs2276314 0.802 rs58906216 chr18:33630297 T/C cg19628046 chr18:33552617 C18orf21 0.5 5.49 0.32 9.61e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs11098499 0.866 rs12374244 chr4:120281972 A/T cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs12971120 0.891 rs2303463 chr18:72168608 G/A cg26446133 chr18:72167187 CNDP2 -0.76 -9.63 -0.51 4.99e-19 Refractive error; CESC cis rs2842992 0.750 rs2758354 chr6:160125854 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.74 8.97 0.48 5.73e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs1055129 0.655 rs8067076 chr17:73837142 G/T cg08125733 chr17:73851984 WBP2 -0.5 -6.88 -0.39 4.23e-11 White matter hyperintensity burden; CESC cis rs7772486 0.875 rs7761033 chr6:146356106 C/T cg05347473 chr6:146136440 FBXO30 0.5 6.51 0.37 3.72e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6696846 0.716 rs6593921 chr1:205062861 A/G cg00857998 chr1:205179979 DSTYK 0.52 7.11 0.4 1.06e-11 Red blood cell count; CESC cis rs2573652 1.000 rs2581363 chr15:100513364 G/A cg00587665 chr15:100533223 ADAMTS17 -0.33 -5.37 -0.31 1.68e-7 Height; CESC cis rs1559088 0.600 rs7255229 chr19:33562807 A/G cg03563238 chr19:33554763 RHPN2 -0.32 -5.85 -0.34 1.46e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs854765 0.663 rs1108648 chr17:17750558 G/A cg16928487 chr17:17741425 SREBF1 0.58 10.25 0.53 5.65e-21 Total body bone mineral density; CESC cis rs9303401 0.614 rs28651036 chr17:57080471 G/A cg12560992 chr17:57184187 TRIM37 0.5 5.21 0.3 3.83e-7 Cognitive test performance; CESC cis rs7945705 0.967 rs56316046 chr11:8876598 G/T cg12365402 chr11:9010492 NRIP3 0.35 5.36 0.31 1.81e-7 Hemoglobin concentration; CESC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg22920501 chr2:26401640 FAM59B -0.93 -10.89 -0.56 4.54e-23 Gut microbiome composition (summer); CESC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg03396347 chr1:1875803 NA -0.33 -5.33 -0.31 2.14e-7 Body mass index; CESC cis rs7927771 1.000 rs7120333 chr11:47817441 C/T cg05585544 chr11:47624801 NA -0.49 -7.71 -0.43 2.62e-13 Subjective well-being; CESC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg08736216 chr1:53307985 ZYG11A -0.33 -5.7 -0.33 3.2e-8 Monocyte count; CESC trans rs1728785 1.000 rs1099296 chr16:68588653 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.82 0.43 1.24e-13 Ulcerative colitis; CESC cis rs9487051 0.714 rs9386797 chr6:109632520 C/A cg01475377 chr6:109611718 NA -0.46 -7.2 -0.4 6.15e-12 Reticulocyte fraction of red cells; CESC cis rs2249625 0.874 rs1830335 chr6:72902788 C/T cg18830697 chr6:72922368 RIMS1 -0.35 -5.06 -0.3 7.97e-7 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs34779708 0.966 rs11599606 chr10:35406626 G/A cg03585969 chr10:35415529 CREM 0.77 10.02 0.52 2.99e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7714584 1.000 rs11950957 chr5:150253914 G/A cg22134413 chr5:150180641 NA 0.51 5.92 0.34 9.88e-9 Crohn's disease; CESC cis rs11155671 0.530 rs7758033 chr6:150208135 T/C cg09699651 chr6:150184138 LRP11 0.55 7.5 0.42 9.65e-13 Testicular germ cell tumor; CESC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.06 10.39 0.54 1.98e-21 Platelet count; CESC cis rs9916302 0.653 rs11654954 chr17:37745979 C/T cg20243544 chr17:37824526 PNMT -0.58 -5.4 -0.31 1.47e-7 Glomerular filtration rate (creatinine); CESC cis rs9291683 0.632 rs10939669 chr4:10045827 A/G cg11266682 chr4:10021025 SLC2A9 0.68 13.29 0.63 3.1e-31 Bone mineral density; CESC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg23803603 chr1:2058230 PRKCZ 0.33 5.81 0.34 1.83e-8 Height; CESC cis rs459571 0.629 rs441233 chr9:136876021 A/G cg13789015 chr9:136890014 NCRNA00094 -0.48 -6.57 -0.37 2.66e-10 Platelet distribution width; CESC cis rs9902453 0.967 rs56326816 chr17:28492805 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.9 0.44 7.44e-14 Coffee consumption (cups per day); CESC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg11366901 chr6:160182831 ACAT2 0.64 8.17 0.45 1.24e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs3806843 1.000 rs10050455 chr5:140204650 A/G cg26395211 chr5:140044315 WDR55 -0.44 -5.49 -0.32 9.2e-8 Depressive symptoms (multi-trait analysis); CESC cis rs9488822 0.676 rs3798227 chr6:116324898 A/G cg15226275 chr6:116381976 FRK 0.25 6.22 0.36 1.94e-9 Cholesterol, total;LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07318050 chr1:233086124 C1orf57 -0.54 -6.44 -0.37 5.72e-10 Gut microbiome composition (summer); CESC trans rs9325144 0.560 rs11182930 chr12:38633693 A/T cg23762105 chr12:34175262 ALG10 0.48 6.31 0.36 1.16e-9 Morning vs. evening chronotype; CESC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg27170947 chr2:26402098 FAM59B 0.87 9.85 0.52 1.01e-19 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06370812 chr3:195501042 MUC4 -0.58 -6.78 -0.38 7.77e-11 Gut microbiome composition (summer); CESC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg18337363 chr3:52569053 NT5DC2 0.3 5.58 0.32 5.86e-8 Electroencephalogram traits; CESC cis rs1577917 0.958 rs36053156 chr6:86575509 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.51 -6.57 -0.37 2.66e-10 Response to antipsychotic treatment; CESC cis rs7697216 0.668 rs28502453 chr4:175837394 G/A cg14561282 chr4:175839468 ADAM29 0.44 5.04 0.3 8.63e-7 Breast cancer; CESC cis rs2290720 0.930 rs4764642 chr12:101691922 C/T cg22051763 chr12:101673672 UTP20 -0.47 -5.8 -0.34 1.88e-8 Brain structure (hippocampal volume); CESC cis rs7412746 0.634 rs4451553 chr1:150937329 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 6.8 0.39 6.96e-11 Melanoma; CESC cis rs11098499 0.739 rs2203039 chr4:120132347 T/C cg09307838 chr4:120376055 NA -0.67 -8.27 -0.45 6.77e-15 Corneal astigmatism; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg23224405 chr12:12715060 DUSP16 0.5 6.55 0.37 2.94e-10 Myopia (pathological); CESC cis rs1878931 0.582 rs9937267 chr16:3421073 C/T cg02880119 chr16:3481970 NA -0.4 -5.22 -0.31 3.67e-7 Body mass index (adult); CESC cis rs2040771 0.770 rs2518840 chr22:19255856 A/C cg02655711 chr22:19163373 SLC25A1 0.41 5.92 0.34 9.81e-9 Metabolite levels (small molecules and protein measures); CESC cis rs9796 0.835 rs11856848 chr15:41370961 C/T cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.23 -0.36 1.78e-9 Menopause (age at onset); CESC cis rs847577 0.506 rs7808528 chr7:97721425 G/T cg24562669 chr7:97807699 LMTK2 0.82 14.13 0.66 3.71e-34 Breast cancer; CESC cis rs79976124 0.879 rs17511467 chr6:66627293 T/C cg07460842 chr6:66804631 NA 0.74 8.58 0.47 7.85e-16 Type 2 diabetes; CESC cis rs2933343 0.649 rs728839 chr3:128589359 A/G cg24203234 chr3:128598194 ACAD9 0.42 5.76 0.33 2.33e-8 IgG glycosylation; CESC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg22920501 chr2:26401640 FAM59B -0.87 -10.07 -0.53 2.06e-20 Gut microbiome composition (summer); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg20782850 chr6:117002205 KPNA5 0.52 6.26 0.36 1.58e-9 Thyroid stimulating hormone; CESC cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -9.52 -0.5 1.15e-18 Extrinsic epigenetic age acceleration; CESC cis rs6460942 0.597 rs4721105 chr7:12534881 C/T cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs7208859 0.623 rs11650982 chr17:29129955 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg18404041 chr3:52824283 ITIH1 -0.4 -6.86 -0.39 4.8e-11 Bipolar disorder; CESC trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg03929089 chr4:120376271 NA -0.91 -15.66 -0.69 1.37e-39 Height; CESC cis rs8068544 0.818 rs79892925 chr17:40171819 A/G cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.94 -8.36 -0.46 3.65e-15 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs9309473 0.500 rs12996463 chr2:73655496 T/C cg20560298 chr2:73613845 ALMS1 0.51 7.2 0.4 6.13e-12 Metabolite levels; CESC cis rs72781680 1.000 rs72781671 chr2:24231123 A/G cg08917208 chr2:24149416 ATAD2B 1.1 9.63 0.51 5.25e-19 Lymphocyte counts; CESC cis rs4555082 0.957 rs3825762 chr14:105752404 T/C cg10792982 chr14:105748885 BRF1 0.37 5.06 0.3 7.93e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7605827 0.930 rs11687253 chr2:15655869 A/G cg19274914 chr2:15703543 NA -0.31 -5.42 -0.32 1.36e-7 Educational attainment (years of education); CESC cis rs559928 0.556 rs11607903 chr11:63932140 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.84 0.34 1.55e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs12479064 0.604 rs11893359 chr2:99954608 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -7.4 -0.41 1.77e-12 Chronic sinus infection; CESC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg09640425 chr7:158790006 NA -0.39 -6.07 -0.35 4.5e-9 Facial morphology (factor 20); CESC cis rs9300255 0.510 rs1727323 chr12:123698790 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.83 0.48 1.41e-16 Neutrophil percentage of white cells; CESC cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg05234568 chr11:5960015 NA -0.59 -6.95 -0.39 2.86e-11 DNA methylation (variation); CESC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg16325326 chr1:53192061 ZYG11B 0.91 15.97 0.7 1.07e-40 Monocyte count; CESC cis rs1881797 1.000 rs10158379 chr1:247686352 C/A cg05639522 chr1:247681581 NA 0.46 6.02 0.35 5.84e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs7208859 0.623 rs9890862 chr17:29125450 C/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2739330 0.892 rs5751776 chr22:24266954 A/C cg18538332 chr22:24372958 LOC391322 -0.81 -12.45 -0.61 2.48e-28 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg09417038 chr21:47716443 C21orf57 0.49 6.73 0.38 1.06e-10 Testicular germ cell tumor; CESC cis rs155076 0.938 rs261375 chr13:21871882 A/G cg11317459 chr13:21872234 NA 1.14 12.64 0.61 5.7e-29 White matter hyperintensity burden; CESC cis rs2228479 0.850 rs3785281 chr16:89824263 G/C cg04013166 chr16:89971882 TCF25 0.79 6.75 0.38 9.14e-11 Skin colour saturation; CESC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.1 0.53 1.64e-20 Prudent dietary pattern; CESC cis rs3796619 0.961 rs11732520 chr4:1074009 C/T cg27284194 chr4:1044797 NA 0.36 5.47 0.32 1.07e-7 Recombination rate (males); CESC cis rs6466055 0.720 rs2030776 chr7:105008458 C/G cg04380332 chr7:105027541 SRPK2 -0.43 -5.73 -0.33 2.75e-8 Schizophrenia; CESC cis rs9457247 0.967 rs433191 chr6:167409662 T/A cg07741184 chr6:167504864 NA 0.3 5.35 0.31 1.86e-7 Crohn's disease; CESC cis rs765787 0.530 rs4238377 chr15:45541981 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17367356 chr11:45907078 MAPK8IP1 -0.48 -6.36 -0.36 8.65e-10 Fibrinogen levels; CESC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2066819 1.000 rs2066808 chr12:56737973 A/G cg26734620 chr12:56694298 CS 0.88 8.75 0.47 2.56e-16 Psoriasis vulgaris; CESC cis rs4906332 1.000 rs7155980 chr14:103922419 C/G cg09975044 chr14:104007538 NA 0.47 6.53 0.37 3.32e-10 Coronary artery disease; CESC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.55 0.37 2.98e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02041137 chr17:3571890 TMEM93;TAX1BP3 0.53 6.15 0.35 2.85e-9 Gut microbiome composition (summer); CESC cis rs7116495 1.000 rs642573 chr11:71780854 G/C cg26138937 chr11:71823887 C11orf51 -0.78 -6.47 -0.37 4.72e-10 Severe influenza A (H1N1) infection; CESC cis rs1559088 1.000 rs1559088 chr19:33551061 C/T cg17764715 chr19:33622953 WDR88 0.45 5.65 0.33 4.14e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs728616 0.867 rs61860420 chr10:81739379 G/A cg05935833 chr10:81318306 SFTPA2 -0.52 -5.06 -0.3 7.72e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -10.25 -0.53 5.55e-21 Chronic sinus infection; CESC cis rs6866344 0.697 rs11748495 chr5:178130000 A/G cg10224037 chr5:178157518 ZNF354A -0.64 -7.0 -0.4 2.1e-11 Neutrophil percentage of white cells; CESC cis rs992157 0.835 rs2292551 chr2:219143229 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.67 -8.69 -0.47 3.72e-16 Colorectal cancer; CESC cis rs7071206 0.947 rs4979902 chr10:79399946 C/T cg00983440 chr10:79422392 NA 0.72 8.85 0.48 1.23e-16 Bone mineral density; CESC trans rs11098499 0.954 rs17046116 chr4:120387259 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.93 0.52 5.63e-20 Corneal astigmatism; CESC cis rs7828089 0.542 rs7332050 chr8:22265294 G/T cg12081754 chr8:22256438 SLC39A14 0.63 8.66 0.47 4.61e-16 Verbal declarative memory; CESC trans rs11039798 0.764 rs10838882 chr11:48393035 T/A cg15704280 chr7:45808275 SEPT13 0.68 6.21 0.36 2.09e-9 Axial length; CESC cis rs6582630 0.519 rs12372510 chr12:38293074 T/C cg13010199 chr12:38710504 ALG10B 0.43 5.43 0.32 1.25e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs9911578 0.839 rs1871751 chr17:57190368 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.3 0.31 2.38e-7 Intelligence (multi-trait analysis); CESC cis rs372883 0.583 rs117214 chr21:30720834 A/G cg24692254 chr21:30365293 RNF160 0.42 5.33 0.31 2.08e-7 Pancreatic cancer; CESC cis rs4919694 1.000 rs78893207 chr10:104796138 T/C cg04362960 chr10:104952993 NT5C2 0.78 6.76 0.38 8.63e-11 Arsenic metabolism; CESC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg17294928 chr15:75287854 SCAMP5 0.51 6.38 0.37 7.72e-10 Breast cancer; CESC cis rs7432375 0.610 rs56163507 chr3:136516056 C/T cg15507776 chr3:136538369 TMEM22 0.6 7.91 0.44 6.92e-14 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs2282802 0.685 rs1529693 chr5:139678213 A/G cg26211634 chr5:139558579 C5orf32 0.48 6.99 0.39 2.29e-11 Intelligence (multi-trait analysis); CESC cis rs757110 0.770 rs11024268 chr11:17387982 A/G cg15432903 chr11:17409602 KCNJ11 0.6 8.5 0.46 1.36e-15 Type 2 diabetes; CESC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.91 0.56 3.81e-23 Alzheimer's disease; CESC cis rs10504073 0.584 rs4873304 chr8:49922733 G/A cg00325661 chr8:49890786 NA 0.55 8.31 0.45 5.1e-15 Blood metabolite ratios; CESC cis rs2228479 0.717 rs2286392 chr16:89809549 A/G cg04287289 chr16:89883240 FANCA 0.71 6.53 0.37 3.42e-10 Skin colour saturation; CESC cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg18099408 chr3:52552593 STAB1 -0.3 -5.05 -0.3 8.36e-7 Bipolar disorder; CESC cis rs2243480 1.000 rs313814 chr7:65503293 C/A cg13147721 chr7:65941812 NA -0.93 -8.89 -0.48 9.72e-17 Diabetic kidney disease; CESC cis rs7772486 0.681 rs9390343 chr6:146010527 A/T cg23711669 chr6:146136114 FBXO30 -0.82 -11.42 -0.57 8.12e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs561341 0.941 rs2428341 chr17:30317295 C/T cg23018236 chr17:30244563 NA -0.45 -5.57 -0.32 6.34e-8 Hip circumference adjusted for BMI; CESC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg18402987 chr7:1209562 NA 0.75 7.45 0.42 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7903847 0.667 rs7096801 chr10:99140969 T/C cg20016023 chr10:99160130 RRP12 -0.29 -5.04 -0.3 8.52e-7 Granulocyte percentage of myeloid white cells; CESC cis rs929596 0.561 rs11891311 chr2:234639310 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.61 8.15 0.45 1.45e-14 Total bilirubin levels in HIV-1 infection; CESC cis rs708547 0.874 rs1630798 chr4:57883558 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.69 7.8 0.43 1.45e-13 Response to bleomycin (chromatid breaks); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg01470323 chr11:66139715 SLC29A2 -0.42 -6.07 -0.35 4.31e-9 Breast cancer; CESC cis rs763014 0.898 rs2017567 chr16:637212 T/C cg09263875 chr16:632152 PIGQ 0.68 11.75 0.59 6.29e-26 Height; CESC cis rs7605827 0.930 rs1852751 chr2:15557320 C/T cg19274914 chr2:15703543 NA 0.36 6.56 0.37 2.83e-10 Educational attainment (years of education); CESC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.32 -0.31 2.19e-7 Menopause (age at onset); CESC cis rs7122539 0.646 rs543191 chr11:66583779 T/G cg24851651 chr11:66362959 CCS 0.49 7.11 0.4 1.08e-11 HIV-1 susceptibility; CESC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg21770322 chr7:97807741 LMTK2 0.55 8.28 0.45 5.99e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs67460515 0.892 rs1382429 chr3:161015153 T/C cg03342759 chr3:160939853 NMD3 -0.52 -7.2 -0.4 6.27e-12 Parkinson's disease; CESC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg18402987 chr7:1209562 NA 0.56 6.69 0.38 1.3e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs425277 1.000 rs262657 chr1:2088577 G/A cg04315214 chr1:2043799 PRKCZ -0.38 -5.25 -0.31 3.19e-7 Height; CESC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg13628971 chr7:2884303 GNA12 0.59 7.86 0.43 9.56e-14 Height; CESC cis rs12479064 0.724 rs2305352 chr2:100015124 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -7.01 -0.4 1.98e-11 Chronic sinus infection; CESC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg24549020 chr5:56110836 MAP3K1 0.58 6.41 0.37 6.79e-10 Initial pursuit acceleration; CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg05564831 chr3:52568323 NT5DC2 0.52 8.88 0.48 1.04e-16 Electroencephalogram traits; CESC cis rs8060686 0.641 rs75450962 chr16:68210868 C/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.03 -0.35 5.55e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs7953249 0.564 rs11065385 chr12:121423386 A/G cg02403541 chr12:121454288 C12orf43 -0.65 -8.68 -0.47 4.12e-16 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs2019216 0.542 rs7217513 chr17:21933536 C/A cg22648282 chr17:21454238 C17orf51 -0.39 -5.07 -0.3 7.37e-7 Pelvic organ prolapse; CESC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg07677032 chr17:61819896 STRADA 0.43 5.37 0.31 1.69e-7 Height; CESC cis rs667920 0.500 rs34498968 chr3:136195130 T/C cg15507776 chr3:136538369 TMEM22 -0.72 -6.1 -0.35 3.66e-9 Coronary artery disease; CESC cis rs2228479 0.541 rs9806913 chr16:89953773 A/G cg06558623 chr16:89946397 TCF25 0.59 5.84 0.34 1.52e-8 Skin colour saturation; CESC cis rs6964587 0.610 rs2888850 chr7:91430027 T/C cg17063962 chr7:91808500 NA 0.43 5.87 0.34 1.3e-8 Breast cancer; CESC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs963731 0.649 rs297139 chr2:39318310 A/G cg04010122 chr2:39346883 SOS1 -0.74 -5.39 -0.31 1.57e-7 Corticobasal degeneration; CESC cis rs3767633 0.925 rs4233380 chr1:161892483 A/C cg09175582 chr1:161736000 ATF6 0.85 6.98 0.39 2.37e-11 IgG glycosylation; CESC cis rs6460942 1.000 rs2053382 chr7:12400587 A/G cg06484146 chr7:12443880 VWDE -0.69 -7.95 -0.44 5.37e-14 Coronary artery disease; CESC cis rs7264396 0.563 rs11906854 chr20:34383634 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.66 6.7 0.38 1.23e-10 Total cholesterol levels; CESC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18783047 chr19:10420351 ZGLP1 0.5 6.67 0.38 1.51e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17411103 chr17:65241599 HELZ 0.63 6.84 0.39 5.5e-11 Gut microbiome composition (summer); CESC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg03517284 chr6:25882590 NA -0.53 -8.0 -0.44 3.89e-14 Blood metabolite levels; CESC cis rs7680126 0.596 rs10022911 chr4:10140551 A/G cg00071950 chr4:10020882 SLC2A9 -0.56 -6.36 -0.36 8.77e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg11764359 chr7:65958608 NA -0.67 -8.62 -0.47 6.05e-16 Corneal structure; CESC cis rs36051895 0.632 rs1571438 chr9:5140313 A/C cg02405213 chr9:5042618 JAK2 -0.49 -6.22 -0.36 1.93e-9 Pediatric autoimmune diseases; CESC cis rs16957304 1.000 rs3868142 chr16:67320223 G/A cg26727032 chr16:67993705 SLC12A4 -0.54 -5.33 -0.31 2.05e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs8017423 0.935 rs2149653 chr14:90669333 G/A cg14092571 chr14:90743983 NA -0.56 -8.28 -0.45 5.95e-15 Mortality in heart failure; CESC cis rs10791323 0.581 rs2723608 chr11:133710149 A/G cg15485101 chr11:133734466 NA 0.4 6.48 0.37 4.47e-10 Childhood ear infection; CESC cis rs684232 0.835 rs1833459 chr17:562244 C/T cg15660573 chr17:549704 VPS53 -0.43 -5.67 -0.33 3.8e-8 Prostate cancer; CESC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.44 5.9 0.34 1.13e-8 Menopause (age at onset); CESC cis rs11997175 0.740 rs4733462 chr8:33679904 A/G ch.8.33884649F chr8:33765107 NA 0.45 5.68 0.33 3.6e-8 Body mass index; CESC cis rs9486715 0.867 rs9373829 chr6:96897201 A/C cg06623918 chr6:96969491 KIAA0776 -0.77 -10.89 -0.56 4.4e-23 Headache; CESC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg09509183 chr1:209979624 IRF6 0.5 6.35 0.36 9.56e-10 Cleft lip with or without cleft palate; CESC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.48 0.37 4.33e-10 Bipolar disorder; CESC cis rs10861342 1.000 rs10861342 chr12:105458797 C/T cg23923672 chr12:105501055 KIAA1033 -0.72 -5.36 -0.31 1.77e-7 IgG glycosylation; CESC trans rs1945213 0.625 rs7128190 chr11:55858550 A/T cg15704280 chr7:45808275 SEPT13 0.76 7.34 0.41 2.57e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs116095464 0.614 rs28736753 chr5:274081 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.54 5.58 0.32 6.07e-8 Breast cancer; CESC cis rs6754311 0.773 rs2322818 chr2:136775898 T/C cg07169764 chr2:136633963 MCM6 0.66 8.21 0.45 9.58e-15 Mosquito bite size; CESC cis rs8016982 0.674 rs1951614 chr14:81672106 A/G cg01989461 chr14:81687754 GTF2A1 -0.74 -11.55 -0.58 2.85e-25 Schizophrenia; CESC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg18876405 chr7:65276391 NA 0.52 6.98 0.39 2.44e-11 Aortic root size; CESC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg17221315 chr6:27791827 HIST1H4J 0.43 5.57 0.32 6.2e-8 Cardiac Troponin-T levels; CESC cis rs3782089 1.000 rs11605810 chr11:65300619 A/G cg21890820 chr11:65308645 LTBP3 1.05 7.95 0.44 5.25e-14 Height; CESC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg13628971 chr7:2884303 GNA12 0.63 8.76 0.47 2.41e-16 Height; CESC cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg16743903 chr16:89593216 SPG7 0.41 5.3 0.31 2.38e-7 Multiple myeloma (IgH translocation); CESC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg26335602 chr6:28129616 ZNF389 0.44 5.59 0.32 5.7e-8 Parkinson's disease; CESC cis rs703842 0.642 rs11536137 chr12:58056426 C/A cg18357645 chr12:58087776 OS9 -0.55 -7.41 -0.41 1.73e-12 Multiple sclerosis; CESC cis rs7539409 0.651 rs970457 chr1:84296540 C/T cg10977910 chr1:84465055 TTLL7 0.75 7.28 0.41 3.76e-12 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15679978 chr6:119255801 MCM9 0.63 7.23 0.41 5.16e-12 Gut microbiome composition (summer); CESC cis rs6456156 0.586 rs12528689 chr6:167461746 A/G cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.13e-10 Primary biliary cholangitis; CESC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg05863683 chr7:1912471 MAD1L1 0.38 5.57 0.32 6.15e-8 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15961887 chr4:71554203 UTP3 0.55 6.45 0.37 5.17e-10 Gut microbiome composition (summer); CESC cis rs4969178 0.930 rs11077363 chr17:76397309 C/T cg05887092 chr17:76393375 PGS1 0.58 9.22 0.49 9.9e-18 HDL cholesterol levels; CESC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg18758796 chr5:131593413 PDLIM4 -0.44 -6.04 -0.35 5.29e-9 Breast cancer; CESC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg16680214 chr1:154839983 KCNN3 -0.44 -6.78 -0.38 7.71e-11 Prostate cancer; CESC cis rs76878669 0.561 rs7117630 chr11:66154777 C/T cg18002602 chr11:66138449 SLC29A2 -0.42 -7.04 -0.4 1.63e-11 Educational attainment (years of education); CESC cis rs2522056 1.000 rs62385693 chr5:131773674 T/C cg24060327 chr5:131705240 SLC22A5 0.65 7.52 0.42 8.51e-13 Lymphocyte counts;Fibrinogen; CESC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg02788857 chr8:22132959 PIWIL2 0.32 5.68 0.33 3.54e-8 Hypertriglyceridemia; CESC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -5.72 -0.33 2.85e-8 Extrinsic epigenetic age acceleration; CESC cis rs2276314 0.857 rs4799409 chr18:33592602 C/T cg05985134 chr18:33552581 C18orf21 0.61 7.33 0.41 2.8e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7560272 0.538 rs12052539 chr2:73937153 C/T cg20560298 chr2:73613845 ALMS1 -0.43 -6.12 -0.35 3.41e-9 Schizophrenia; CESC cis rs3931020 0.508 rs2345436 chr1:75198740 A/C cg10128416 chr1:75198403 TYW3;CRYZ 0.46 5.53 0.32 7.52e-8 Resistin levels; CESC cis rs4308124 0.708 rs61358692 chr2:111965159 T/C cg04571233 chr2:111982156 NA -0.63 -6.91 -0.39 3.58e-11 Vitiligo; CESC cis rs453301 0.571 rs2929452 chr8:9084465 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -6.75 -0.38 9.56e-11 Joint mobility (Beighton score); CESC cis rs7520050 0.966 rs785503 chr1:46595868 T/C cg03146154 chr1:46216737 IPP -0.43 -5.58 -0.32 6e-8 Red blood cell count;Reticulocyte count; CESC cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg09060608 chr5:178986726 RUFY1 -0.4 -5.59 -0.33 5.5e-8 Lung cancer; CESC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 5.91 0.34 1.03e-8 Electroencephalogram traits; CESC cis rs644799 1.000 rs3748256 chr11:95521953 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.72 9.58 0.51 7.54e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg22508957 chr16:3507546 NAT15 0.59 9.56 0.51 8.29e-19 Tuberculosis; CESC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg12311346 chr5:56204834 C5orf35 -0.75 -8.9 -0.48 8.71e-17 Initial pursuit acceleration; CESC cis rs684232 0.602 rs2543775 chr17:557123 G/A cg12384639 chr17:618140 VPS53 0.41 5.23 0.31 3.42e-7 Prostate cancer; CESC cis rs12476592 0.602 rs2121351 chr2:63828361 G/A cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC cis rs7210086 0.950 rs7214193 chr17:70641865 A/G cg04206342 chr17:70636940 NA -0.3 -5.2 -0.3 4.02e-7 Ulcerative colitis; CESC cis rs6502050 0.765 rs6502074 chr17:80121776 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.63 -0.38 1.85e-10 Life satisfaction; CESC cis rs858239 0.600 rs6967475 chr7:23128982 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.37 0.41 2.18e-12 Cerebrospinal fluid biomarker levels; CESC cis rs12142240 0.698 rs1057533 chr1:46815836 C/T cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10705503 chr12:102513685 C12orf48;NUP37 -0.45 -6.25 -0.36 1.61e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg07167872 chr1:205819463 PM20D1 0.76 11.86 0.59 2.64e-26 Menarche (age at onset); CESC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg23172400 chr8:95962367 TP53INP1 -0.5 -10.94 -0.56 3.12e-23 Type 2 diabetes; CESC cis rs7523050 0.643 rs36047249 chr1:109401499 T/C cg08274380 chr1:109419600 GPSM2 0.86 5.69 0.33 3.36e-8 Fat distribution (HIV); CESC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg23281280 chr6:28129359 ZNF389 0.37 5.46 0.32 1.1e-7 Parkinson's disease; CESC cis rs2019216 0.542 rs2221893 chr17:21930012 A/G cg22648282 chr17:21454238 C17orf51 -0.4 -5.26 -0.31 2.95e-7 Pelvic organ prolapse; CESC cis rs2439831 0.850 rs12441861 chr15:44060883 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.69 8.02 0.44 3.51e-14 Lung cancer in ever smokers; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02250680 chr11:58346542 LPXN;ZFP91-CNTF;ZFP91 -0.51 -6.55 -0.37 2.92e-10 Ulcerative colitis; CESC cis rs4474465 0.736 rs4945291 chr11:78254413 C/T cg27205649 chr11:78285834 NARS2 0.42 5.32 0.31 2.16e-7 Alzheimer's disease (survival time); CESC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg05564831 chr3:52568323 NT5DC2 0.46 7.37 0.41 2.17e-12 Bipolar disorder; CESC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg12463550 chr7:65579703 CRCP -0.54 -6.92 -0.39 3.37e-11 Aortic root size; CESC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg02569458 chr12:86230093 RASSF9 -0.46 -7.15 -0.4 8.28e-12 Major depressive disorder; CESC cis rs7512552 0.839 rs12045304 chr1:150399818 G/A cg15654264 chr1:150340011 RPRD2 0.41 5.35 0.31 1.94e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs722599 0.599 rs3825708 chr14:75200697 C/T cg08847533 chr14:75593920 NEK9 0.44 5.34 0.31 2e-7 IgG glycosylation; CESC cis rs72772090 0.539 rs11743410 chr5:96124453 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.26 -0.31 3.01e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9929218 0.551 rs2296406 chr16:68721340 G/A cg02972257 chr16:68554789 NA -0.42 -5.14 -0.3 5.29e-7 Colorectal cancer; CESC cis rs854765 0.583 rs4925126 chr17:17798633 C/T cg04398451 chr17:18023971 MYO15A -0.69 -10.06 -0.53 2.22e-20 Total body bone mineral density; CESC cis rs4925386 0.840 rs6143024 chr20:60914229 A/G cg22307297 chr20:60903441 LAMA5 0.41 5.5 0.32 8.86e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg11764359 chr7:65958608 NA -0.68 -8.81 -0.48 1.68e-16 Aortic root size; CESC cis rs9303401 1.000 rs9904677 chr17:56873025 A/G cg12560992 chr17:57184187 TRIM37 0.49 5.54 0.32 7.42e-8 Cognitive test performance; CESC cis rs9488822 0.676 rs11153594 chr6:116354591 A/G cg26893134 chr6:116381904 FRK -0.26 -6.33 -0.36 1.07e-9 Cholesterol, total;LDL cholesterol; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18664336 chr17:57970265 TUBD1;RPS6KB1 -0.46 -6.25 -0.36 1.64e-9 Asthma; CESC cis rs11122272 0.735 rs2437148 chr1:231513979 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs2439831 0.681 rs524527 chr15:43599116 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.9 -13.08 -0.63 1.75e-30 Lung cancer in ever smokers; CESC cis rs12618769 0.625 rs4850878 chr2:99112180 T/A cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs4588572 0.688 rs1594055 chr5:77695088 G/A cg11547950 chr5:77652471 NA -0.41 -5.71 -0.33 2.99e-8 Triglycerides; CESC cis rs12579753 0.672 rs4509857 chr12:82268017 C/T cg21193143 chr12:82153300 PPFIA2 -0.34 -5.2 -0.3 4.09e-7 Resting heart rate; CESC cis rs262150 0.544 rs2428780 chr7:158812471 T/A cg19418458 chr7:158789849 NA -0.41 -6.22 -0.36 1.88e-9 Facial morphology (factor 20); CESC cis rs2637266 0.690 rs2579730 chr10:78443441 G/T cg18941641 chr10:78392320 NA 0.4 7.31 0.41 3.07e-12 Pulmonary function; CESC cis rs1878931 0.513 rs35160989 chr16:3405506 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.92 14.05 0.65 7e-34 Body mass index (adult); CESC cis rs9925964 0.933 rs4889530 chr16:31065918 T/A cg02466173 chr16:30829666 NA 0.32 5.13 0.3 5.55e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg04944784 chr2:26401820 FAM59B 0.61 6.97 0.39 2.5e-11 Gut microbiome composition (summer); CESC cis rs11112613 0.713 rs73184082 chr12:105951748 T/C cg03607813 chr12:105948248 NA 0.59 7.41 0.41 1.75e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs2777491 0.957 rs316614 chr15:41746625 A/G cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.9 -0.52 7.01e-20 Ulcerative colitis; CESC cis rs1712517 0.524 rs4917384 chr10:104995788 T/C cg04362960 chr10:104952993 NT5C2 0.48 5.59 0.32 5.62e-8 Migraine; CESC cis rs6121246 0.529 rs6060359 chr20:30209740 A/G cg13852791 chr20:30311386 BCL2L1 0.59 5.49 0.32 9.22e-8 Mean corpuscular hemoglobin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08434295 chr5:175815816 HIGD2A;NOP16 0.53 6.08 0.35 4.25e-9 Gut microbiome composition (summer); CESC cis rs3747547 0.818 rs6476665 chr9:37948238 A/C cg13774184 chr9:37916125 SHB -0.56 -5.86 -0.34 1.38e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs4711336 1.000 rs4711336 chr6:33659046 A/G cg14003231 chr6:33640908 ITPR3 -0.35 -5.86 -0.34 1.35e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11028586 chr17:33307483 LIG3 0.57 6.26 0.36 1.53e-9 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18368637 chr6:144179905 LTV1 -0.49 -6.15 -0.35 2.89e-9 Gut microbiota (bacterial taxa); CESC cis rs62005083 1.000 rs62005145 chr14:74588106 A/G cg05179529 chr14:74551516 LIN52;ALDH6A1 0.7 5.25 0.31 3.08e-7 Mean corpuscular volume; CESC cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg20476274 chr7:133979776 SLC35B4 -0.63 -8.99 -0.48 4.94e-17 Mean platelet volume; CESC cis rs12220238 0.841 rs7919010 chr10:76111137 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.52 5.1 0.3 6.35e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs10861342 1.000 rs1076 chr12:105562788 C/T cg23923672 chr12:105501055 KIAA1033 -0.65 -5.14 -0.3 5.25e-7 IgG glycosylation; CESC trans rs17685 0.712 rs7794454 chr7:75776010 A/G cg19862616 chr7:65841803 NCRNA00174 -0.8 -11.44 -0.57 6.72e-25 Coffee consumption;Coffee consumption (cups per day); CESC trans rs113577745 0.725 rs59015435 chr2:10129252 G/A cg12379383 chr15:96896940 NA -0.59 -6.3 -0.36 1.24e-9 Breast cancer; CESC cis rs7589342 0.862 rs10469862 chr2:106509907 C/T cg14210321 chr2:106509881 NCK2 -0.45 -5.05 -0.3 8.09e-7 Addiction; CESC cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg21573476 chr21:45109991 RRP1B -0.5 -6.86 -0.39 4.89e-11 Mean corpuscular volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01618530 chr8:54755981 ATP6V1H -0.51 -6.12 -0.35 3.38e-9 Ulcerative colitis; CESC cis rs7520050 0.966 rs12410071 chr1:46358886 T/C cg24296786 chr1:45957014 TESK2 0.42 5.26 0.31 2.92e-7 Red blood cell count;Reticulocyte count; CESC cis rs2635047 0.811 rs17785603 chr18:44769534 T/A cg24371990 chr18:44770781 NA 0.43 6.95 0.39 2.92e-11 Educational attainment; CESC cis rs7208859 0.623 rs216445 chr17:28933576 A/G cg19761014 chr17:28927070 LRRC37B2 0.85 6.59 0.38 2.33e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs9494142 0.592 rs1547247 chr6:135390836 C/T cg22676075 chr6:135203613 NA 0.7 8.88 0.48 1.07e-16 Lymphocyte counts;Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11240327 chr6:90348503 LYRM2 -0.47 -5.99 -0.35 6.64e-9 Ulcerative colitis; CESC cis rs8141529 0.732 rs5762815 chr22:29205076 A/G cg15103426 chr22:29168792 CCDC117 0.7 9.91 0.52 6.78e-20 Lymphocyte counts; CESC cis rs1008375 0.931 rs6449309 chr4:17573208 C/T cg02297831 chr4:17616191 MED28 0.53 6.12 0.35 3.31e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12618769 0.597 rs72819981 chr2:99040696 T/C cg10123293 chr2:99228465 UNC50 0.39 5.1 0.3 6.52e-7 Bipolar disorder; CESC cis rs79839061 0.518 rs11734537 chr4:869174 A/G cg07828340 chr4:882639 GAK 1.07 8.28 0.45 6.09e-15 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26530261 chr16:27280164 NSMCE1 0.56 6.05 0.35 5.01e-9 Gut microbiome composition (summer); CESC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg09177884 chr7:1199841 ZFAND2A -0.55 -6.17 -0.35 2.5e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2276314 0.857 rs28651028 chr18:33638910 G/A cg05985134 chr18:33552581 C18orf21 0.62 7.36 0.41 2.32e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs6754311 0.551 rs2304599 chr2:136528004 C/G cg07169764 chr2:136633963 MCM6 -0.73 -9.35 -0.5 3.95e-18 Mosquito bite size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10828910 chr2:63850056 LOC388955 0.4 6.01 0.35 6.07e-9 Gambling; CESC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg03709012 chr19:19516395 GATAD2A 0.96 14.18 0.66 2.35e-34 Tonsillectomy; CESC trans rs7246760 0.867 rs55846005 chr19:9796709 T/A cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs1707322 1.000 rs12060274 chr1:46291062 G/T cg03146154 chr1:46216737 IPP 0.72 9.83 0.52 1.2e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7647973 0.592 rs6774202 chr3:49687779 T/G cg03060546 chr3:49711283 APEH 0.69 8.47 0.46 1.73e-15 Menarche (age at onset); CESC cis rs9910055 0.530 rs2269908 chr17:42294198 G/C cg10896456 chr17:42255109 ASB16;C17orf65 0.34 5.03 0.3 8.93e-7 Total body bone mineral density; CESC cis rs916888 0.821 rs199505 chr17:44859410 A/G cg15921436 chr17:44337874 NA -0.68 -7.54 -0.42 7.6e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11122272 0.735 rs2355872 chr1:231478489 A/T cg06096015 chr1:231504339 EGLN1 0.43 6.36 0.36 8.84e-10 Hemoglobin concentration; CESC cis rs61935443 0.614 rs11107787 chr12:95311669 C/T cg21533806 chr12:95267307 NA 0.48 5.29 0.31 2.54e-7 Schizophrenia; CESC cis rs6460942 0.915 rs2192842 chr7:12315752 C/G cg20607287 chr7:12443886 VWDE -0.42 -6.21 -0.36 2.09e-9 Coronary artery disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg27649522 chr12:12877729 APOLD1 0.45 6.06 0.35 4.78e-9 Systemic lupus erythematosus; CESC cis rs4722166 1.000 rs4722166 chr7:22738762 G/T cg05472934 chr7:22766657 IL6 0.59 7.28 0.41 3.84e-12 Lung cancer; CESC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.76 -10.97 -0.56 2.42e-23 Age at first birth; CESC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg03609598 chr5:56110824 MAP3K1 -0.51 -5.32 -0.31 2.22e-7 Initial pursuit acceleration; CESC cis rs2228479 0.867 rs62056110 chr16:89946388 A/C cg00800038 chr16:89945340 TCF25 -0.88 -7.85 -0.43 1.01e-13 Skin colour saturation; CESC cis rs11958404 0.615 rs10475649 chr5:157447301 T/C cg05962755 chr5:157440814 NA 0.38 5.65 0.33 4.21e-8 IgG glycosylation; CESC cis rs10949834 0.838 rs1091811 chr7:73491212 A/G cg07137043 chr7:73588983 EIF4H 0.66 7.24 0.41 4.99e-12 Verbal memory performance (residualized delayed recall change); CESC cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg18357645 chr12:58087776 OS9 -0.39 -5.45 -0.32 1.13e-7 Multiple sclerosis; CESC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.74 6.19 0.36 2.23e-9 Platelet count; CESC trans rs3198697 1.000 rs3198697 chr16:15129940 C/T cg04146151 chr16:2155961 PKD1 -0.63 -8.06 -0.44 2.62e-14 Triglycerides; CESC cis rs1881797 1.000 rs1881796 chr1:247688931 G/A cg21399703 chr1:247681439 NA 0.55 7.36 0.41 2.29e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs4423214 0.592 rs79634040 chr11:71230169 G/C cg05163923 chr11:71159392 DHCR7 -0.57 -5.92 -0.34 1e-8 Vitamin D levels; CESC cis rs6088580 0.634 rs1205334 chr20:32930369 T/C cg24642439 chr20:33292090 TP53INP2 -0.51 -6.66 -0.38 1.58e-10 Glomerular filtration rate (creatinine); CESC cis rs9303280 0.901 rs8067378 chr17:38051348 A/G cg19468946 chr17:37922297 IKZF3 -0.39 -5.34 -0.31 2.02e-7 Self-reported allergy; CESC cis rs1371867 0.846 rs1660353 chr8:101250907 C/T cg06002616 chr8:101225028 SPAG1 0.31 5.05 0.3 8.34e-7 Atrioventricular conduction; CESC cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg01448562 chr3:133502909 NA -0.44 -6.2 -0.36 2.21e-9 Iron status biomarkers; CESC cis rs4727963 0.846 rs4727961 chr7:122716343 T/A cg03640110 chr7:122635026 TAS2R16 -0.38 -5.84 -0.34 1.55e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs672059 1.000 rs625917 chr1:183157991 T/G ch.1.3577855R chr1:183094577 LAMC1 0.54 6.97 0.39 2.51e-11 Hypertriglyceridemia; CESC cis rs9815354 0.680 rs57945879 chr3:42038842 C/G cg03022575 chr3:42003672 ULK4 0.75 6.57 0.37 2.63e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs1707322 1.000 rs7532204 chr1:46485075 C/G cg03146154 chr1:46216737 IPP -0.72 -9.88 -0.52 8.55e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg26874164 chr19:58962979 ZNF324B 0.54 7.41 0.41 1.73e-12 Uric acid clearance; CESC trans rs11039798 0.588 rs12284168 chr11:48555627 C/T cg03929089 chr4:120376271 NA 0.62 6.07 0.35 4.44e-9 Axial length; CESC cis rs763121 0.853 rs1056610 chr22:39080078 C/T cg06022373 chr22:39101656 GTPBP1 -0.94 -16.93 -0.72 4.35e-44 Menopause (age at onset); CESC cis rs4604732 0.642 rs7549312 chr1:247640078 C/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.46 6.5 0.37 3.87e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2760061 0.583 rs708110 chr1:228190805 T/A cg02753203 chr1:228287806 NA 0.79 11.5 0.58 4.28e-25 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00721207 chr19:40337107 FBL 0.58 6.38 0.36 7.81e-10 Gut microbiome composition (summer); CESC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg18402987 chr7:1209562 NA 0.75 7.46 0.42 1.25e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs1493916 0.721 rs4471760 chr18:31374233 G/A cg27147174 chr7:100797783 AP1S1 -0.49 -6.34 -0.36 1e-9 Life satisfaction; CESC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg25072359 chr17:41440525 NA 0.5 6.72 0.38 1.14e-10 Menopause (age at onset); CESC cis rs7727544 0.684 rs272849 chr5:131690241 A/G cg24060327 chr5:131705240 SLC22A5 -0.59 -7.79 -0.43 1.49e-13 Blood metabolite levels; CESC cis rs7264396 0.563 rs2425132 chr20:34338390 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -10.24 -0.53 5.76e-21 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11586605 chr11:108535779 DDX10 0.62 7.52 0.42 8.39e-13 Gut microbiome composition (summer); CESC trans rs7947523 0.813 rs4999940 chr11:80942337 C/T cg08862778 chr1:11322643 MTOR 0.46 6.29 0.36 1.31e-9 Emphysema imaging phenotypes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04329845 chr19:14640100 MIR639;TECR -0.46 -5.99 -0.35 6.66e-9 Ulcerative colitis; CESC cis rs12410462 0.581 rs77837509 chr1:227559873 C/T cg23173402 chr1:227635558 NA 0.63 5.39 0.31 1.52e-7 Major depressive disorder; CESC cis rs7659604 0.540 rs11724322 chr4:122697850 A/T cg19671926 chr4:122722719 EXOSC9 0.65 8.64 0.47 5.34e-16 Type 2 diabetes; CESC cis rs9894429 0.789 rs8074989 chr17:79598728 G/C cg18240062 chr17:79603768 NPLOC4 0.9 13.2 0.63 6.66e-31 Eye color traits; CESC trans rs853679 0.607 rs17763089 chr6:27835218 G/A cg06606381 chr12:133084897 FBRSL1 -1.07 -8.89 -0.48 9.48e-17 Depression; CESC cis rs9649465 0.967 rs9641717 chr7:123350060 C/T cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.34e-7 Migraine; CESC cis rs6502050 0.835 rs7406529 chr17:80080877 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.53 0.37 3.27e-10 Life satisfaction; CESC cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg23462726 chr11:62437636 C11orf83;C11orf48 -0.43 -5.73 -0.33 2.73e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg26597838 chr10:835615 NA 0.87 9.02 0.48 3.81e-17 Eosinophil percentage of granulocytes; CESC trans rs11098499 0.954 rs7681544 chr4:120411255 T/C cg25214090 chr10:38739885 LOC399744 0.72 10.08 0.53 1.97e-20 Corneal astigmatism; CESC cis rs3793683 0.825 rs3793674 chr10:134555773 C/T cg18305652 chr10:134549665 INPP5A -0.34 -5.35 -0.31 1.92e-7 Migraine; CESC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.54 -8.28 -0.45 6.11e-15 IgG glycosylation; CESC cis rs9583531 0.891 rs61969076 chr13:111391568 C/T cg24331049 chr13:111365604 ING1 -0.71 -7.06 -0.4 1.45e-11 Coronary artery disease; CESC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg08736216 chr1:53307985 ZYG11A -0.38 -6.25 -0.36 1.65e-9 Monocyte count; CESC cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 6.1e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.18 0.3 4.33e-7 Electroencephalogram traits; CESC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg04877737 chr22:50155965 NA 0.33 5.35 0.31 1.87e-7 Schizophrenia; CESC cis rs9287719 0.935 rs728283 chr2:10750090 C/T cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs72945132 0.882 rs67822447 chr11:70230972 G/T cg00319359 chr11:70116639 PPFIA1 0.73 7.1 0.4 1.11e-11 Coronary artery disease; CESC cis rs854765 0.583 rs62064158 chr17:17826935 T/C cg04398451 chr17:18023971 MYO15A -0.67 -9.6 -0.51 6.42e-19 Total body bone mineral density; CESC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg11814155 chr7:99998594 ZCWPW1 -0.49 -5.24 -0.31 3.3e-7 Platelet count; CESC cis rs7777484 0.571 rs2527686 chr7:2834413 G/A cg09658497 chr7:2847517 GNA12 -0.44 -6.95 -0.39 2.75e-11 Height; CESC cis rs116095464 0.558 rs13356367 chr5:242395 C/T cg10591111 chr5:226296 SDHA -0.52 -6.38 -0.36 7.94e-10 Breast cancer; CESC cis rs2806561 0.734 rs667211 chr1:23516142 T/C cg12483005 chr1:23474871 LUZP1 0.38 6.0 0.35 6.44e-9 Height; CESC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg22823121 chr1:150693482 HORMAD1 0.47 7.03 0.4 1.79e-11 Tonsillectomy; CESC cis rs7107174 1.000 rs7111986 chr11:78102266 G/T cg02023728 chr11:77925099 USP35 0.47 6.3 0.36 1.24e-9 Testicular germ cell tumor; CESC cis rs2625529 0.824 rs4777470 chr15:72207518 T/A cg16672083 chr15:72433130 SENP8 -0.39 -5.09 -0.3 6.78e-7 Red blood cell count; CESC cis rs36051895 0.664 rs3824433 chr9:5113577 C/T cg02405213 chr9:5042618 JAK2 -0.49 -6.15 -0.35 2.77e-9 Pediatric autoimmune diseases; CESC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg18404041 chr3:52824283 ITIH1 -0.45 -7.48 -0.42 1.1e-12 Bipolar disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16078886 chr18:29673278 RNF138 -0.48 -6.0 -0.35 6.52e-9 Asthma; CESC cis rs116095464 0.558 rs62347683 chr5:230331 C/T cg22857025 chr5:266934 NA -1.28 -18.8 -0.76 1.06e-50 Breast cancer; CESC cis rs35110281 0.626 rs162367 chr21:44934857 A/G cg21573476 chr21:45109991 RRP1B -0.36 -5.19 -0.3 4.28e-7 Mean corpuscular volume; CESC cis rs2806561 0.929 rs2746556 chr1:23524541 G/A cg12483005 chr1:23474871 LUZP1 0.32 5.16 0.3 4.81e-7 Height; CESC cis rs2236918 1.000 rs2526704 chr1:242015820 A/G cg17736920 chr1:242011382 EXO1 0.75 9.96 0.52 4.79e-20 Menopause (age at onset); CESC cis rs6502050 0.871 rs8066970 chr17:80076051 T/C cg11859384 chr17:80120422 CCDC57 0.4 5.52 0.32 8.22e-8 Life satisfaction; CESC cis rs2777491 0.574 rs316616 chr15:41746276 G/A cg20272979 chr15:41787780 ITPKA 0.42 5.18 0.3 4.32e-7 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12882907 chr12:96428593 LTA4H -0.52 -6.23 -0.36 1.84e-9 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg00166722 chr3:10149974 C3orf24 0.49 6.3 0.36 1.24e-9 Alzheimer's disease; CESC cis rs2797160 0.651 rs1269176 chr6:126029682 A/T cg05901451 chr6:126070800 HEY2 -0.51 -7.44 -0.42 1.38e-12 Endometrial cancer; CESC cis rs6831352 0.918 rs29001232 chr4:100046654 G/C cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg00684032 chr4:1343700 KIAA1530 0.35 5.41 0.32 1.39e-7 Obesity-related traits; CESC cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg05347473 chr6:146136440 FBXO30 -0.52 -6.32 -0.36 1.1e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs372883 0.600 rs1153276 chr21:30661694 T/C cg24692254 chr21:30365293 RNF160 -0.61 -7.76 -0.43 1.82e-13 Pancreatic cancer; CESC trans rs9987353 0.518 rs4841110 chr8:9086023 C/T cg15556689 chr8:8085844 FLJ10661 0.51 6.05 0.35 5.01e-9 Recombination measurement; CESC cis rs17539620 0.624 rs62432743 chr6:154836214 T/G cg17771515 chr6:154831774 CNKSR3 0.59 5.87 0.34 1.31e-8 Lipoprotein (a) levels; CESC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg11644478 chr21:40555479 PSMG1 1.01 16.1 0.7 4.01e-41 Cognitive function; CESC cis rs733592 1.000 rs733592 chr12:48429776 C/T cg24011408 chr12:48396354 COL2A1 -0.51 -8.16 -0.45 1.37e-14 Plateletcrit; CESC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg05315796 chr3:52349193 DNAH1 -0.32 -5.59 -0.32 5.75e-8 Electroencephalogram traits; CESC cis rs7666738 0.830 rs13124904 chr4:98856973 T/C cg03467027 chr4:99064603 C4orf37 0.42 5.16 0.3 4.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3026101 0.576 rs56188406 chr17:5316769 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.58 0.32 5.93e-8 Body mass index; CESC cis rs4727027 0.704 rs7787753 chr7:148901779 A/T cg23583168 chr7:148888333 NA -0.94 -17.46 -0.73 5.9e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs61774743 0.521 rs60144015 chr1:41845246 C/A cg08462924 chr1:41848221 NA 0.43 6.0 0.35 6.55e-9 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16635483 chr3:96338407 NA -0.45 -6.03 -0.35 5.49e-9 Gut microbiota (bacterial taxa); CESC cis rs8072100 0.840 rs9900360 chr17:45491979 C/T cg08085267 chr17:45401833 C17orf57 -0.53 -7.22 -0.41 5.35e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6582630 0.519 rs12582285 chr12:38298753 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9911578 0.805 rs1811202 chr17:56454435 T/G cg12560992 chr17:57184187 TRIM37 -0.8 -12.62 -0.61 6.74e-29 Intelligence (multi-trait analysis); CESC cis rs3820068 0.603 rs72647128 chr1:15963908 T/C cg16988262 chr1:15930761 NA 0.34 5.45 0.32 1.16e-7 Systolic blood pressure; CESC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -5.82 -0.34 1.71e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2273669 0.667 rs12198182 chr6:109318704 T/G cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs870825 0.616 rs4443323 chr4:185629805 C/A cg04058563 chr4:185651563 MLF1IP 0.64 6.48 0.37 4.51e-10 Blood protein levels; CESC cis rs9467711 0.790 rs13195401 chr6:26463574 G/T cg14345882 chr6:26364793 BTN3A2 0.63 5.15 0.3 4.99e-7 Autism spectrum disorder or schizophrenia; CESC cis rs72781680 1.000 rs72796388 chr2:24171509 A/C cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs7208859 0.623 rs9906957 chr17:29157755 C/T cg13385521 chr17:29058706 SUZ12P 0.72 5.76 0.33 2.3e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs921968 0.565 rs35594672 chr2:219589280 T/A cg02176678 chr2:219576539 TTLL4 -0.43 -7.59 -0.42 5.51e-13 Mean corpuscular hemoglobin concentration; CESC trans rs7246760 0.867 rs67634928 chr19:9802397 C/G cg02900749 chr2:68251473 NA -0.82 -7.19 -0.4 6.67e-12 Pursuit maintenance gain; CESC cis rs1008375 0.966 rs4235389 chr4:17696280 A/G cg02297831 chr4:17616191 MED28 0.42 5.19 0.3 4.15e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs829883 0.622 rs7302630 chr12:98959577 C/A cg25150519 chr12:98850993 NA -0.6 -7.14 -0.4 8.96e-12 Colorectal adenoma (advanced); CESC cis rs9314323 0.501 rs6557911 chr8:26189230 G/T cg11498726 chr8:26250323 BNIP3L -0.43 -6.08 -0.35 4.16e-9 Red cell distribution width; CESC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg19077165 chr18:44547161 KATNAL2 -0.55 -7.99 -0.44 4.2e-14 Personality dimensions; CESC cis rs7520050 0.966 rs4076006 chr1:46438076 C/T cg24296786 chr1:45957014 TESK2 0.44 5.5 0.32 8.98e-8 Red blood cell count;Reticulocyte count; CESC cis rs4588572 0.706 rs72760906 chr5:77652457 T/C cg11547950 chr5:77652471 NA 0.46 6.12 0.35 3.41e-9 Triglycerides; CESC cis rs28489187 0.706 rs233113 chr1:85786299 T/A cg16011679 chr1:85725395 C1orf52 0.48 5.65 0.33 4.1e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs7301826 0.651 rs10744483 chr12:131298206 C/A cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC cis rs6061231 0.583 rs2427313 chr20:60970675 G/A cg22541963 chr20:60982533 CABLES2 0.51 6.13 0.35 3.13e-9 Colorectal cancer; CESC cis rs9660992 0.710 rs1668867 chr1:205240251 C/T cg21643547 chr1:205240462 TMCC2 -0.49 -6.94 -0.39 3.04e-11 Mean corpuscular volume;Mean platelet volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10763906 chr12:111052079 TCTN1 -0.43 -6.03 -0.35 5.43e-9 Gambling; CESC cis rs4594175 0.926 rs66625118 chr14:51631062 T/C cg23942311 chr14:51606299 NA 0.41 6.22 0.36 1.95e-9 Cancer; CESC cis rs2952156 0.920 rs2517953 chr17:37841211 G/C cg19468946 chr17:37922297 IKZF3 -0.41 -5.18 -0.3 4.35e-7 Asthma; CESC cis rs3749237 0.595 rs7637999 chr3:49535115 C/T cg03060546 chr3:49711283 APEH 0.77 11.82 0.59 3.5e-26 Resting heart rate; CESC cis rs8020095 0.528 rs73282769 chr14:67780267 A/G cg19548862 chr14:67692701 FAM71D -0.45 -5.44 -0.32 1.21e-7 Depression (quantitative trait); CESC cis rs1045714 0.848 rs73033686 chr7:2635085 C/G cg20813462 chr7:2646259 IQCE 0.68 5.85 0.34 1.48e-8 Urate levels in lean individuals; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09262732 chr7:100285913 GIGYF1 -0.5 -7.0 -0.4 2.11e-11 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05429508 chr4:517674 PIGG -0.67 -7.7 -0.43 2.7e-13 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg07701084 chr6:150067640 NUP43 0.45 6.28 0.36 1.41e-9 Lung cancer; CESC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg23958373 chr8:599963 NA 0.81 6.75 0.38 9.46e-11 IgG glycosylation; CESC cis rs941873 0.868 rs7332 chr10:81114060 G/A cg08514558 chr10:81106712 PPIF 0.36 6.22 0.36 1.94e-9 Height; CESC cis rs116095464 0.558 rs6872854 chr5:209038 G/T cg22496380 chr5:211416 CCDC127 -0.71 -8.38 -0.46 3.17e-15 Breast cancer; CESC cis rs4722166 0.597 rs2069845 chr7:22770149 G/A cg05265849 chr7:22767390 IL6 0.41 5.72 0.33 2.88e-8 Lung cancer; CESC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg18876405 chr7:65276391 NA -0.5 -6.83 -0.39 5.93e-11 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12159980 chr4:878727 GAK -0.49 -6.0 -0.35 6.38e-9 Gut microbiome composition (summer); CESC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg01570182 chr17:44337453 NA 0.63 8.59 0.47 7.82e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7044106 0.718 rs10616 chr9:123363533 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.58 0.32 5.89e-8 Hip circumference adjusted for BMI; CESC cis rs9549260 0.755 rs4429172 chr13:41189143 C/A cg21288729 chr13:41239152 FOXO1 0.61 7.66 0.43 3.49e-13 Red blood cell count; CESC cis rs7843479 1.000 rs13276082 chr8:21823184 A/G cg17168535 chr8:21777572 XPO7 0.47 6.3 0.36 1.24e-9 Mean corpuscular volume; CESC cis rs3820068 0.608 rs9660255 chr1:16031891 T/G cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.35 4.28e-9 Systolic blood pressure; CESC cis rs965469 0.779 rs6037566 chr20:3331414 A/C cg17110299 chr20:3385021 C20orf194 0.4 5.25 0.31 3.1e-7 IFN-related cytopenia; CESC cis rs3741151 1.000 rs76764824 chr11:73073580 C/T cg17517138 chr11:73019481 ARHGEF17 1.0 6.71 0.38 1.18e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs11098499 1.000 rs11098499 chr4:120187611 C/T cg09307838 chr4:120376055 NA 0.88 11.93 0.59 1.55e-26 Corneal astigmatism; CESC cis rs12413816 0.784 rs11258560 chr10:13770137 A/G cg16485048 chr10:13749193 FRMD4A 0.48 5.89 0.34 1.14e-8 Red cell distribution width; CESC cis rs12476592 0.602 rs11898615 chr2:63748284 C/A cg17519650 chr2:63277830 OTX1 -0.48 -5.56 -0.32 6.41e-8 Childhood ear infection; CESC cis rs912057 0.526 rs737449 chr6:6733729 A/G cg06612196 chr6:6737390 NA -0.47 -8.49 -0.46 1.51e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs4790333 0.537 rs898750 chr17:2255193 A/G cg02569219 chr17:2266849 SGSM2 0.39 5.06 0.3 7.9e-7 Proinsulin levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24344221 chr1:35658281 SFPQ 0.46 6.21 0.36 2.06e-9 Fibrinogen levels; CESC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg08470875 chr2:26401718 FAM59B 0.76 8.06 0.44 2.69e-14 Gut microbiome composition (summer); CESC cis rs7927592 0.956 rs10896341 chr11:68313180 G/A cg20283391 chr11:68216788 NA -0.61 -7.36 -0.41 2.26e-12 Total body bone mineral density; CESC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2370759 1.000 rs79442609 chr10:32608749 C/T cg01819863 chr10:32635814 EPC1 1.15 12.33 0.6 6.5e-28 Sexual dysfunction (female); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06400595 chr12:56551642 MYL6B;MYL6 0.66 7.72 0.43 2.42e-13 Gut microbiome composition (summer); CESC cis rs6032067 0.777 rs17332620 chr20:43777506 C/T cg11264863 chr20:43835661 SEMG1 0.48 5.25 0.31 3.08e-7 Blood protein levels; CESC cis rs9300255 0.602 rs884548 chr12:123634122 A/G cg00376283 chr12:123451042 ABCB9 0.71 8.76 0.47 2.38e-16 Neutrophil percentage of white cells; CESC cis rs727505 0.866 rs17327181 chr7:124720303 A/G cg23710748 chr7:124431027 NA -0.4 -6.52 -0.37 3.55e-10 Lewy body disease; CESC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.24 -0.31 3.25e-7 Gut microbiome composition (summer); CESC cis rs3747547 1.000 rs72724184 chr9:37916731 C/T cg13774184 chr9:37916125 SHB -0.72 -5.94 -0.34 9.09e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs959260 1.000 rs9900002 chr17:73382018 T/A cg20590849 chr17:73267439 MIF4GD -0.57 -6.73 -0.38 1.07e-10 Systemic lupus erythematosus; CESC cis rs6570726 1.000 rs404229 chr6:145868200 G/A cg23711669 chr6:146136114 FBXO30 0.76 11.13 0.56 7.48e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg05890377 chr2:74357713 NA 0.76 10.02 0.52 3.01e-20 Gestational age at birth (maternal effect); CESC cis rs1568889 0.838 rs10835304 chr11:28296529 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 13.44 0.64 9.4e-32 Bipolar disorder; CESC cis rs17376456 0.825 rs10079708 chr5:93261796 G/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.65 5.32 0.31 2.26e-7 Diabetic retinopathy; CESC cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg24879335 chr3:133465180 TF 0.34 5.8 0.34 1.85e-8 Iron status biomarkers; CESC cis rs4481887 1.000 rs4593862 chr1:248480176 G/T cg00666640 chr1:248458726 OR2T12 0.41 6.55 0.37 2.99e-10 Common traits (Other); CESC cis rs367943 1.000 rs2248930 chr5:112811119 G/T cg12552261 chr5:112820674 MCC -0.62 -7.73 -0.43 2.27e-13 Type 2 diabetes; CESC cis rs2228479 0.850 rs2238525 chr16:89809902 T/C cg04013166 chr16:89971882 TCF25 0.69 6.98 0.39 2.4e-11 Skin colour saturation; CESC cis rs11997175 0.713 rs4733455 chr8:33651290 C/T ch.8.33884649F chr8:33765107 NA -0.57 -7.3 -0.41 3.42e-12 Body mass index; CESC cis rs17539620 0.534 rs7768635 chr6:154827861 C/T cg20019720 chr6:154832845 CNKSR3 0.42 6.17 0.35 2.61e-9 Lipoprotein (a) levels; CESC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg24250549 chr1:154909240 PMVK 0.72 10.45 0.54 1.28e-21 Prostate cancer; CESC cis rs9905704 0.846 rs35082135 chr17:56939694 A/G cg12560992 chr17:57184187 TRIM37 0.63 7.73 0.43 2.25e-13 Testicular germ cell tumor; CESC cis rs11645898 0.935 rs72787077 chr16:72156674 C/T cg14768367 chr16:72042858 DHODH -0.69 -5.95 -0.34 8.43e-9 Blood protein levels; CESC cis rs4076764 0.958 rs11580702 chr1:163385523 C/G cg24596788 chr1:163392923 NA -0.5 -7.36 -0.41 2.31e-12 Motion sickness; CESC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg00802000 chr16:706648 WDR90 -0.4 -6.0 -0.35 6.41e-9 Height; CESC cis rs4888262 0.508 rs4462623 chr16:74692426 C/T cg01733217 chr16:74700730 RFWD3 0.91 12.26 0.6 1.14e-27 Testicular germ cell tumor; CESC cis rs3105593 0.563 rs8033532 chr15:50959618 G/T cg08437265 chr15:50716283 USP8 0.41 5.34 0.31 2e-7 QT interval; CESC cis rs17253792 0.822 rs113350960 chr14:56087713 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.98 0.34 7.23e-9 Putamen volume; CESC cis rs3820928 0.904 rs10933161 chr2:227764872 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -5.33 -0.31 2.06e-7 Pulmonary function; CESC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg12334488 chr2:20871173 GDF7 -0.37 -5.64 -0.33 4.27e-8 Abdominal aortic aneurysm; CESC cis rs4481887 0.861 rs4644528 chr1:248472508 T/A cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs6582630 0.524 rs10785494 chr12:38532431 C/G cg26384229 chr12:38710491 ALG10B -0.43 -5.78 -0.33 2.15e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13110034 chr1:145470261 ANKRD34A;POLR3GL 0.68 7.27 0.41 3.98e-12 Gut microbiome composition (summer); CESC cis rs7917772 0.503 rs56397707 chr10:104302693 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.33 0.41 2.81e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7727544 0.678 rs7735891 chr5:131597005 C/T cg14196790 chr5:131705035 SLC22A5 0.38 5.63 0.33 4.5e-8 Blood metabolite levels; CESC cis rs2463822 0.547 rs72917373 chr11:62024403 C/A cg06239285 chr11:62104954 ASRGL1 -1.01 -7.52 -0.42 8.29e-13 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs3020736 0.500 rs2413669 chr22:42507748 A/C cg04733989 chr22:42467013 NAGA -0.78 -11.9 -0.59 1.87e-26 Autism spectrum disorder or schizophrenia; CESC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg10862848 chr6:42927986 GNMT -0.26 -6.63 -0.38 1.89e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.17e-12 Tonsillectomy; CESC cis rs7829975 0.871 rs7829826 chr8:8578120 T/A cg17143192 chr8:8559678 CLDN23 -0.44 -5.48 -0.32 9.91e-8 Mood instability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06819775 chr12:69004359 RAP1B 0.57 6.73 0.38 1.06e-10 Gut microbiome composition (summer); CESC cis rs61931739 0.500 rs11053185 chr12:34428857 A/G cg06521331 chr12:34319734 NA -0.38 -5.18 -0.3 4.32e-7 Morning vs. evening chronotype; CESC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg04553112 chr3:125709451 NA -0.5 -5.45 -0.32 1.13e-7 Blood pressure (smoking interaction); CESC cis rs2415984 0.622 rs10147795 chr14:46936528 C/T cg14871534 chr14:47121158 RPL10L -0.34 -5.17 -0.3 4.55e-7 Number of children ever born; CESC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg18876405 chr7:65276391 NA 0.47 6.15 0.35 2.9e-9 Aortic root size; CESC cis rs116095464 0.558 rs6882584 chr5:223411 A/C cg22496380 chr5:211416 CCDC127 -0.72 -8.57 -0.47 8.59e-16 Breast cancer; CESC cis rs478304 0.900 rs502468 chr11:65525119 T/G cg08755490 chr11:65554678 OVOL1 0.49 6.5 0.37 3.95e-10 Acne (severe); CESC cis rs7584330 0.554 rs55919896 chr2:238428823 A/T cg14458575 chr2:238380390 NA 0.54 6.16 0.35 2.74e-9 Prostate cancer; CESC cis rs752010 0.684 rs10789402 chr1:42084649 A/G cg12614395 chr1:42085415 HIVEP3 0.29 5.09 0.3 6.84e-7 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23800573 chr21:45114399 RRP1B -0.57 -6.72 -0.38 1.12e-10 Gut microbiome composition (summer); CESC cis rs6963495 0.818 rs6961233 chr7:105150469 C/T cg19920283 chr7:105172520 RINT1 0.66 6.28 0.36 1.36e-9 Bipolar disorder (body mass index interaction); CESC cis rs3087591 0.960 rs2905869 chr17:29519016 C/A cg24425628 chr17:29625626 OMG;NF1 0.44 5.55 0.32 7.1e-8 Hip circumference; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15639469 chr5:79596224 LOC644936 -0.63 -7.55 -0.42 7.2e-13 Gut microbiome composition (summer); CESC cis rs826838 0.967 rs1486345 chr12:39131677 G/A cg26384229 chr12:38710491 ALG10B -0.67 -11.03 -0.56 1.63e-23 Heart rate; CESC cis rs6460942 0.915 rs62447640 chr7:12488282 A/T cg10578991 chr7:12443926 VWDE -0.49 -5.22 -0.31 3.59e-7 Coronary artery disease; CESC cis rs11792861 0.816 rs3818932 chr9:111664178 T/C cg13535736 chr9:111863775 C9orf5 -0.45 -5.87 -0.34 1.33e-8 Menarche (age at onset); CESC cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg18782716 chr15:41709119 RTF1 -0.46 -6.03 -0.35 5.52e-9 Height; CESC cis rs9549367 0.789 rs3764124 chr13:113897320 C/T cg18105134 chr13:113819100 PROZ -0.7 -8.23 -0.45 8.61e-15 Platelet distribution width; CESC cis rs909002 0.849 rs871634 chr1:32093167 G/C cg13919466 chr1:32135498 COL16A1 -0.48 -8.26 -0.45 7.11e-15 Intelligence (multi-trait analysis); CESC cis rs3105593 1.000 rs3131578 chr15:50861470 C/T cg08437265 chr15:50716283 USP8 -0.42 -5.54 -0.32 7.45e-8 QT interval; CESC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg18252515 chr7:66147081 NA 0.48 6.45 0.37 5.42e-10 Aortic root size; CESC cis rs12313068 0.709 rs73404675 chr12:110504102 G/A cg12870014 chr12:110450643 ANKRD13A 0.82 9.18 0.49 1.24e-17 Intelligence (multi-trait analysis); CESC trans rs2207136 0.835 rs2817349 chr6:50891226 T/C cg06522515 chr3:184090630 THPO -0.34 -6.03 -0.35 5.53e-9 Myopia; CESC cis rs2250402 0.510 rs2898984 chr15:40324075 G/C cg16127683 chr15:40268777 EIF2AK4 -0.63 -5.78 -0.33 2.15e-8 Corneal curvature; CESC cis rs539096 0.500 rs2367804 chr1:44314266 C/T cg23954153 chr1:44402353 ARTN -0.35 -5.39 -0.31 1.54e-7 Intelligence (multi-trait analysis); CESC cis rs6963495 0.719 rs73190172 chr7:105161210 T/C cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs6121246 0.909 rs6060644 chr20:30265652 G/A cg13852791 chr20:30311386 BCL2L1 0.77 8.18 0.45 1.17e-14 Mean corpuscular hemoglobin; CESC cis rs1059312 0.966 rs7135968 chr12:129280066 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.74 -10.51 -0.54 8.05e-22 Systemic lupus erythematosus; CESC cis rs9457247 0.602 rs10484530 chr6:167461562 C/T cg23791538 chr6:167370224 RNASET2 -0.52 -6.87 -0.39 4.45e-11 Crohn's disease; CESC cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg22875332 chr1:76189707 ACADM -0.63 -6.66 -0.38 1.6e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7824557 0.724 rs2572398 chr8:11178093 A/C cg21775007 chr8:11205619 TDH 0.41 5.71 0.33 2.97e-8 Retinal vascular caliber; CESC cis rs7103648 0.864 rs12801188 chr11:47388214 G/A cg20307385 chr11:47447363 PSMC3 0.92 13.54 0.64 4.17e-32 Diastolic blood pressure;Systolic blood pressure; CESC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg05585544 chr11:47624801 NA -0.46 -6.9 -0.39 3.94e-11 Subjective well-being; CESC cis rs4243830 0.737 rs56036909 chr1:6608503 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.92 8.76 0.47 2.41e-16 Body mass index; CESC cis rs7116495 0.609 rs674319 chr11:71775391 T/C cg10381502 chr11:71823885 C11orf51 -1.14 -7.14 -0.4 8.75e-12 Severe influenza A (H1N1) infection; CESC trans rs13205180 0.550 rs10948676 chr6:51983591 C/T cg14179581 chr1:50881502 NA -0.28 -6.14 -0.35 3.06e-9 Diastolic blood pressure; CESC cis rs7927592 0.763 rs624003 chr11:68231240 C/T cg16797656 chr11:68205561 LRP5 0.49 7.32 0.41 2.98e-12 Total body bone mineral density; CESC cis rs8072100 0.817 rs9912101 chr17:45547078 A/G cg25173405 chr17:45401733 C17orf57 -0.47 -6.15 -0.35 2.92e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg12193833 chr17:30244370 NA -0.71 -6.55 -0.37 3.04e-10 Hip circumference adjusted for BMI; CESC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg08470875 chr2:26401718 FAM59B -0.74 -7.65 -0.43 3.74e-13 Gut microbiome composition (summer); CESC cis rs6681460 1.000 rs1325263 chr1:67129791 C/A cg02459107 chr1:67143332 SGIP1 0.38 5.24 0.31 3.28e-7 Presence of antiphospholipid antibodies; CESC cis rs826838 1.000 rs10880826 chr12:38672787 G/C cg13010199 chr12:38710504 ALG10B 0.59 8.31 0.45 5.12e-15 Heart rate; CESC cis rs12545109 0.800 rs2670026 chr8:57424338 G/T cg09654669 chr8:57350985 NA -0.46 -6.31 -0.36 1.18e-9 Obesity-related traits; CESC cis rs7247513 0.897 rs12972944 chr19:12713808 G/A cg01871581 chr19:12707946 ZNF490 -0.89 -14.6 -0.67 7.84e-36 Bipolar disorder; CESC cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.42 -5.59 -0.32 5.75e-8 Intelligence (multi-trait analysis); CESC cis rs7727544 0.735 rs272884 chr5:131668654 G/C cg07395648 chr5:131743802 NA -0.46 -6.06 -0.35 4.78e-9 Blood metabolite levels; CESC cis rs2066819 1.000 rs2020854 chr12:56743367 T/C cg26316697 chr12:56727976 PAN2 0.72 6.94 0.39 2.92e-11 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00007036 chr1:33742089 ZNF362 -0.55 -6.25 -0.36 1.59e-9 Gut microbiome composition (summer); CESC cis rs16854884 0.657 rs13078840 chr3:143700753 A/G cg06585982 chr3:143692056 C3orf58 0.45 5.62 0.33 4.88e-8 Economic and political preferences (feminism/equality); CESC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg11764359 chr7:65958608 NA 0.79 9.51 0.5 1.18e-18 Aortic root size; CESC cis rs11711311 1.000 rs13073843 chr3:113449150 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.27 0.53 4.81e-21 IgG glycosylation; CESC cis rs1152591 0.524 rs1255991 chr14:64661642 G/A cg23250157 chr14:64679961 SYNE2 0.41 5.81 0.34 1.8e-8 Atrial fibrillation; CESC cis rs11166629 1.000 rs966659 chr8:135639045 C/T cg27224718 chr8:135614730 ZFAT -0.5 -6.28 -0.36 1.36e-9 Smoking quantity; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg18924771 chr5:166582591 NA -0.45 -6.3 -0.36 1.24e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg08392591 chr16:89556376 ANKRD11 0.56 7.63 0.42 4.29e-13 Multiple myeloma (IgH translocation); CESC cis rs7177699 0.557 rs7178051 chr15:79118296 A/G cg04896959 chr15:78267971 NA -0.32 -5.04 -0.3 8.66e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC trans rs7618501 0.932 rs4855850 chr3:49761571 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -8.48 -0.46 1.62e-15 Intelligence (multi-trait analysis); CESC cis rs7474896 0.559 rs2738185 chr10:38247736 G/A cg25427524 chr10:38739819 LOC399744 0.5 5.62 0.33 4.72e-8 Obesity (extreme); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13554667 chr10:62538283 CDK1;CDC2 0.57 6.18 0.35 2.37e-9 Gut microbiome composition (summer); CESC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg23048001 chr7:2026167 MAD1L1 0.45 5.75 0.33 2.44e-8 Bipolar disorder and schizophrenia; CESC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg22903657 chr4:1355424 KIAA1530 0.41 5.66 0.33 3.92e-8 Obesity-related traits; CESC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.21 0.3 3.79e-7 Tonsillectomy; CESC cis rs709400 1.000 rs55885592 chr14:104126024 C/T cg24130564 chr14:104152367 KLC1 -0.42 -5.41 -0.32 1.44e-7 Body mass index; CESC cis rs34779708 0.966 rs17499811 chr10:35456215 G/A cg03585969 chr10:35415529 CREM 0.77 10.32 0.54 3.35e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg07701084 chr6:150067640 NUP43 0.48 6.69 0.38 1.35e-10 Lung cancer; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G ch.15.84283968F chr15:86482964 NA 0.48 6.43 0.37 5.99e-10 Neuroticism; CESC cis rs11785400 1.000 rs4484678 chr8:143730796 A/G cg10596483 chr8:143751796 JRK 0.41 5.41 0.32 1.43e-7 Schizophrenia; CESC cis rs763014 0.865 rs2018789 chr16:632051 T/C cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01600100 chr12:96794307 CDK17 -0.5 -6.58 -0.37 2.49e-10 Fibrinogen levels; CESC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg06456125 chr7:65229604 NA 0.43 5.49 0.32 9.18e-8 Aortic root size; CESC cis rs1348850 0.519 rs1527407 chr2:178525630 T/G cg23306229 chr2:178417860 TTC30B 0.46 5.39 0.31 1.59e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6674176 0.597 rs9326136 chr1:44390392 A/G cg13606994 chr1:44402422 ARTN 0.4 6.42 0.37 6.24e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08063013 chr11:63742144 COX8A 0.47 6.12 0.35 3.28e-9 Systemic lupus erythematosus; CESC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg20151795 chr6:28129481 ZNF389 0.46 6.0 0.35 6.52e-9 Depression; CESC cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg19912559 chr1:40204330 PPIE 0.4 6.11 0.35 3.53e-9 Blood protein levels; CESC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg13770153 chr20:60521292 NA -0.47 -6.22 -0.36 1.94e-9 Body mass index; CESC cis rs684232 0.602 rs8064796 chr17:525937 A/C cg15660573 chr17:549704 VPS53 -0.81 -11.99 -0.59 9.07e-27 Prostate cancer; CESC cis rs17253792 0.822 rs17685102 chr14:56129214 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs12220238 0.818 rs16931294 chr10:75999169 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.68 7.22 0.41 5.47e-12 Soluble interleukin-2 receptor subunit alpha; CESC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg18252515 chr7:66147081 NA -0.46 -6.05 -0.35 5e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26922706 chr5:133513036 SKP1 -0.54 -6.17 -0.35 2.59e-9 Gut microbiome composition (summer); CESC trans rs116095464 0.558 rs11959126 chr5:283880 T/G cg00938859 chr5:1591904 SDHAP3 0.65 7.03 0.4 1.73e-11 Breast cancer; CESC cis rs7647973 0.580 rs35218722 chr3:49275805 A/G cg03060546 chr3:49711283 APEH 0.51 6.97 0.39 2.58e-11 Menarche (age at onset); CESC cis rs722599 0.683 rs10139016 chr14:75274288 T/C cg08847533 chr14:75593920 NEK9 0.49 5.86 0.34 1.38e-8 IgG glycosylation; CESC cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg10494973 chr17:80897199 TBCD -0.45 -5.6 -0.33 5.37e-8 Breast cancer; CESC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg15664640 chr17:80829946 TBCD -0.39 -5.8 -0.34 1.86e-8 Breast cancer; CESC cis rs10791323 0.660 rs10791332 chr11:133732150 A/G cg15485101 chr11:133734466 NA 0.39 6.56 0.37 2.86e-10 Childhood ear infection; CESC cis rs2404602 0.669 rs12148877 chr15:76919959 T/G cg22467129 chr15:76604101 ETFA -0.36 -5.32 -0.31 2.25e-7 Blood metabolite levels; CESC cis rs34779708 0.733 rs4244997 chr10:35547254 T/C cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg07317108 chr10:11575102 USP6NL 0.42 6.33 0.36 1.04e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9325144 0.647 rs12822023 chr12:39097964 T/C cg26384229 chr12:38710491 ALG10B -0.5 -7.06 -0.4 1.47e-11 Morning vs. evening chronotype; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26035463 chr12:117627651 FBXO21 0.54 6.77 0.38 8.32e-11 Gut microbiota (bacterial taxa); CESC cis rs7216064 0.953 rs80135947 chr17:65836001 A/C cg12091567 chr17:66097778 LOC651250 -0.86 -8.83 -0.48 1.49e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02872018 chr2:192746213 NA 0.45 6.34 0.36 9.6e-10 Ulcerative colitis; CESC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg04267008 chr7:1944627 MAD1L1 -0.63 -7.72 -0.43 2.43e-13 Bipolar disorder and schizophrenia; CESC cis rs698833 0.501 rs12473699 chr2:44507673 G/A cg04920474 chr2:44395004 PPM1B 0.47 6.71 0.38 1.19e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs6942407 0.696 rs4400318 chr7:86860524 A/C cg02420886 chr7:86849541 C7orf23 0.54 5.19 0.3 4.27e-7 Food allergy; CESC cis rs2249625 1.000 rs2249625 chr6:72906753 C/T cg18830697 chr6:72922368 RIMS1 0.41 5.86 0.34 1.38e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg26119090 chr2:26468346 HADHA;HADHB -0.71 -8.0 -0.44 3.99e-14 Gut microbiome composition (summer); CESC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg13206674 chr6:150067644 NUP43 0.42 5.83 0.34 1.63e-8 Lung cancer; CESC cis rs72781680 0.716 rs78332127 chr2:24150163 C/G cg08917208 chr2:24149416 ATAD2B 0.61 6.08 0.35 4.2e-9 Lymphocyte counts; CESC cis rs7872515 0.887 rs10820937 chr9:94840206 T/C cg01248375 chr9:94877805 SPTLC1 0.53 5.94 0.34 8.91e-9 Bipolar disorder and schizophrenia; CESC cis rs561341 0.663 rs72821936 chr17:30224068 C/G cg13647721 chr17:30228624 UTP6 0.83 10.86 0.55 5.68e-23 Hip circumference adjusted for BMI; CESC cis rs3820928 0.874 rs4234062 chr2:227819050 C/A cg11843606 chr2:227700838 RHBDD1 -0.43 -5.68 -0.33 3.62e-8 Pulmonary function; CESC cis rs11971779 0.646 rs58682779 chr7:139084712 C/T cg07862535 chr7:139043722 LUC7L2 0.56 5.65 0.33 4.1e-8 Diisocyanate-induced asthma; CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg09033563 chr22:24373618 LOC391322 -0.44 -5.66 -0.33 3.88e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9611565 0.559 rs8139993 chr22:41995335 T/C cg06481639 chr22:41940642 POLR3H -0.56 -6.28 -0.36 1.37e-9 Vitiligo; CESC cis rs701145 0.556 rs191651 chr3:153973887 T/G cg16511985 chr3:153974050 SGEF 0.42 5.64 0.33 4.26e-8 Coronary artery disease; CESC cis rs2075371 0.932 rs11766132 chr7:133993062 T/C cg00033643 chr7:134001901 SLC35B4 0.43 5.48 0.32 1e-7 Mean platelet volume; CESC cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg12927641 chr6:109611667 NA -0.43 -6.63 -0.38 1.91e-10 Reticulocyte fraction of red cells; CESC cis rs11048434 0.736 rs1805724 chr12:9104609 T/C cg23795048 chr12:9217529 LOC144571 0.36 5.66 0.33 4.02e-8 Sjögren's syndrome; CESC cis rs7605827 0.930 rs1990754 chr2:15615910 A/G cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs10197940 0.662 rs72860233 chr2:152289767 G/A cg19508488 chr2:152266495 RIF1 0.51 5.62 0.33 4.95e-8 Lung cancer; CESC cis rs9894429 0.646 rs7406828 chr17:79619226 A/G cg18240062 chr17:79603768 NPLOC4 -0.47 -6.18 -0.36 2.35e-9 Eye color traits; CESC cis rs67311347 1.000 rs11129876 chr3:40401636 C/T cg09455208 chr3:40491958 NA -0.48 -7.9 -0.44 7.38e-14 Renal cell carcinoma; CESC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg23161317 chr6:28129485 ZNF389 0.49 6.19 0.36 2.28e-9 Parkinson's disease; CESC trans rs11098499 0.754 rs714899 chr4:120243035 G/A cg25214090 chr10:38739885 LOC399744 0.64 9.06 0.49 2.97e-17 Corneal astigmatism; CESC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.97 14.35 0.66 5.99e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs2018683 0.933 rs12536127 chr7:28985967 T/C cg19402173 chr7:128379420 CALU -0.6 -7.89 -0.44 7.74e-14 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs6088590 0.603 rs6579186 chr20:33282198 G/C cg24642439 chr20:33292090 TP53INP2 0.69 9.19 0.49 1.21e-17 Coronary artery disease; CESC cis rs6942756 0.955 rs55638303 chr7:128885770 C/T cg02491457 chr7:128862824 NA -0.68 -9.62 -0.51 5.66e-19 White matter hyperintensity burden; CESC cis rs11240074 0.516 rs61838368 chr1:146963986 C/T cg25205988 chr1:146714368 CHD1L -0.56 -5.07 -0.3 7.35e-7 Type 2 diabetes; CESC cis rs9611565 0.694 rs202613 chr22:41821993 C/A cg06634786 chr22:41940651 POLR3H 0.71 7.17 0.4 7.6e-12 Vitiligo; CESC cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.42 0.32 1.34e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9894429 0.646 rs8080391 chr17:79566319 A/T cg18240062 chr17:79603768 NPLOC4 -0.86 -12.65 -0.61 5.01e-29 Eye color traits; CESC cis rs4523957 0.579 rs2270478 chr17:2089848 G/A cg16513277 chr17:2031491 SMG6 -0.63 -8.81 -0.48 1.7e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg10351095 chr21:47802916 PCNT -0.53 -6.45 -0.37 5.32e-10 Testicular germ cell tumor; CESC cis rs11690935 0.921 rs3770445 chr2:172708919 T/C cg13550731 chr2:172543902 DYNC1I2 -0.95 -14.35 -0.66 5.85e-35 Schizophrenia; CESC cis rs870825 0.860 rs56180712 chr4:185600223 A/G cg04058563 chr4:185651563 MLF1IP 0.57 5.29 0.31 2.54e-7 Blood protein levels; CESC cis rs238295 0.805 rs6053527 chr20:5582457 G/T cg24001556 chr20:5591874 RP5-1022P6.2 -0.46 -5.22 -0.31 3.64e-7 Occipital cortical area (total cortical area interaction); CESC cis rs34172651 0.687 rs8044992 chr16:24811207 T/C cg06505273 chr16:24850292 NA 0.41 5.23 0.31 3.41e-7 Intelligence (multi-trait analysis); CESC cis rs3859192 0.557 rs12602514 chr17:38159745 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.62 9.18 0.49 1.3e-17 White blood cell count; CESC cis rs7216064 1.000 rs11869819 chr17:65868669 A/C cg12091567 chr17:66097778 LOC651250 -0.85 -8.7 -0.47 3.61e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9303401 1.000 rs7218362 chr17:56888299 A/G cg12560992 chr17:57184187 TRIM37 0.49 5.55 0.32 7.07e-8 Cognitive test performance; CESC cis rs1401999 1.000 rs13317532 chr3:183641669 G/C cg01324343 chr3:183735012 ABCC5 0.64 13.44 0.64 9.67e-32 Anterior chamber depth; CESC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg02931644 chr1:25747376 RHCE -0.41 -6.87 -0.39 4.49e-11 Erythrocyte sedimentation rate; CESC cis rs9296736 0.961 rs9370260 chr6:53921674 T/C cg04374786 chr6:53939321 C6orf142 0.33 5.15 0.3 4.98e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg13206674 chr6:150067644 NUP43 0.4 5.72 0.33 2.8e-8 Lung cancer; CESC cis rs10463316 0.894 rs10062856 chr5:150768196 C/G cg03212797 chr5:150827313 SLC36A1 -0.47 -6.15 -0.35 2.86e-9 Metabolite levels (Pyroglutamine); CESC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg25036284 chr2:26402008 FAM59B 0.83 9.66 0.51 4.25e-19 Gut microbiome composition (summer); CESC cis rs4812048 0.649 rs116580814 chr20:57618141 G/T cg14073986 chr20:57617431 SLMO2 0.78 6.29 0.36 1.3e-9 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14722716 chr4:48833041 OCIAD1 0.57 6.41 0.37 6.57e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27587257 chr11:1002310 AP2A2 0.42 6.26 0.36 1.58e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19826439 chr1:226297528 NA 0.66 7.83 0.43 1.16e-13 Gut microbiome composition (summer); CESC cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg12292205 chr6:26970375 C6orf41 -0.48 -5.57 -0.32 6.18e-8 Intelligence (multi-trait analysis); CESC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg07507251 chr3:52567010 NT5DC2 0.42 7.37 0.41 2.24e-12 Bipolar disorder; CESC cis rs1055129 0.560 rs3682 chr17:73942150 A/G cg02678768 chr17:74002944 EVPL 0.37 5.12 0.3 5.96e-7 White matter hyperintensity burden; CESC cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg14440974 chr22:39074834 NA -0.42 -5.66 -0.33 3.87e-8 Menopause (age at onset); CESC cis rs761746 0.960 rs4820980 chr22:31917415 A/G cg25791279 chr22:32026902 PISD -0.53 -6.14 -0.35 2.94e-9 Intelligence; CESC cis rs8103278 1.000 rs8109951 chr19:46289503 C/T cg11657440 chr19:46296263 DMWD -0.61 -7.75 -0.43 1.99e-13 Coronary artery disease; CESC cis rs7216064 0.953 rs1599859 chr17:65837193 C/G cg12091567 chr17:66097778 LOC651250 -0.8 -9.0 -0.48 4.4e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10463316 0.894 rs4099170 chr5:150766583 G/A cg03212797 chr5:150827313 SLC36A1 -0.47 -6.2 -0.36 2.17e-9 Metabolite levels (Pyroglutamine); CESC cis rs637571 0.544 rs500161 chr11:65695438 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 5.75 0.33 2.42e-8 Eosinophil percentage of white cells; CESC cis rs854765 0.718 rs6502629 chr17:17869642 A/G cg09796270 chr17:17721594 SREBF1 0.43 5.74 0.33 2.6e-8 Total body bone mineral density; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg05370988 chr3:186500739 EIF4A2 0.43 6.04 0.35 5.09e-9 Neuroticism; CESC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg13206674 chr6:150067644 NUP43 0.44 6.53 0.37 3.39e-10 Lung cancer; CESC cis rs559928 0.597 rs2096706 chr11:63924446 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.6 0.33 5.22e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg27121462 chr16:89883253 FANCA 0.73 10.57 0.54 5.04e-22 Vitiligo; CESC cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.35 0.31 1.9e-7 Personality dimensions; CESC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg16325326 chr1:53192061 ZYG11B 0.9 14.84 0.67 1.12e-36 Monocyte count; CESC cis rs4654899 1.000 rs7537072 chr1:21434533 T/C cg05370193 chr1:21551575 ECE1 0.38 5.63 0.33 4.66e-8 Superior frontal gyrus grey matter volume; CESC cis rs2742234 0.590 rs2435383 chr10:43675671 T/C cg07801480 chr10:43725741 RASGEF1A 0.41 5.29 0.31 2.56e-7 Hirschsprung disease; CESC cis rs7818688 0.697 rs75349998 chr8:95990918 G/A cg16049864 chr8:95962084 TP53INP1 0.56 5.67 0.33 3.78e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs8027181 1.000 rs3850986 chr15:73091283 G/T cg25632853 chr15:73088954 NA 0.36 6.45 0.37 5.23e-10 Triglyceride levels; CESC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg22143856 chr6:28129313 ZNF389 0.53 6.71 0.38 1.2e-10 Depression; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24905370 chr5:74063138 NSA2;GFM2 -0.45 -6.09 -0.35 3.88e-9 Asthma; CESC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg07308232 chr7:1071921 C7orf50 -0.45 -6.25 -0.36 1.65e-9 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05992347 chr16:33964783 MIR1826 -0.58 -6.38 -0.36 7.69e-10 Gut microbiome composition (summer); CESC cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg11752832 chr7:134001865 SLC35B4 0.55 7.23 0.41 5.27e-12 Mean platelet volume; CESC cis rs10189230 0.967 rs12613015 chr2:222356119 G/A cg14652038 chr2:222343519 EPHA4 0.35 7.21 0.41 5.68e-12 Urate levels in lean individuals; CESC cis rs919433 0.857 rs36071109 chr2:198183191 C/A cg10820045 chr2:198174542 NA -0.37 -5.13 -0.3 5.66e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg15017067 chr4:17643749 FAM184B 0.38 5.09 0.3 6.76e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9462846 0.691 rs7744454 chr6:42914041 C/G cg02353165 chr6:42928485 GNMT 0.55 6.35 0.36 9.17e-10 Blood protein levels; CESC cis rs3892630 0.588 rs28787932 chr19:33226229 T/C cg13157960 chr19:33183277 NUDT19 0.54 5.35 0.31 1.88e-7 Red blood cell traits; CESC cis rs72634258 0.945 rs34157438 chr1:8023586 C/T cg00042356 chr1:8021962 PARK7 0.91 8.22 0.45 9.03e-15 Inflammatory bowel disease; CESC cis rs1008375 0.932 rs11938710 chr4:17670664 G/C cg02297831 chr4:17616191 MED28 -0.5 -5.84 -0.34 1.55e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7580658 0.724 rs71414745 chr2:127992588 A/G cg10021288 chr2:128175891 PROC -0.37 -5.89 -0.34 1.2e-8 Protein C levels; CESC cis rs12765878 1.000 rs35223321 chr10:105646395 C/T cg11005552 chr10:105648138 OBFC1 0.36 5.27 0.31 2.85e-7 Coronary artery disease; CESC cis rs7640424 0.716 rs35703078 chr3:107859558 A/G cg09227934 chr3:107805635 CD47 -0.47 -6.15 -0.35 2.9e-9 Body mass index; CESC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.17 -0.4 7.54e-12 Total body bone mineral density; CESC cis rs4604732 0.536 rs76191272 chr1:247628055 A/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.09 0.3 6.91e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4481887 0.732 rs4526647 chr1:248423788 C/G cg00666640 chr1:248458726 OR2T12 0.36 6.01 0.35 6.25e-9 Common traits (Other); CESC cis rs6541297 1.000 rs4846838 chr1:230281618 G/A cg20703242 chr1:230279135 GALNT2 0.66 9.05 0.49 3.16e-17 Coronary artery disease; CESC cis rs62064224 0.702 rs2302277 chr17:30791509 C/G cg25809561 chr17:30822961 MYO1D 0.63 9.12 0.49 1.92e-17 Schizophrenia; CESC cis rs116095464 1.000 rs6873902 chr5:313337 C/G cg22857025 chr5:266934 NA -1.2 -10.6 -0.55 4.2e-22 Breast cancer; CESC trans rs7980799 0.935 rs10844580 chr12:33553867 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.0 -0.4 2.12e-11 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs74781061 0.858 rs8023865 chr15:74853604 G/A cg17294928 chr15:75287854 SCAMP5 -0.5 -5.4 -0.31 1.46e-7 Endometriosis; CESC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg12463550 chr7:65579703 CRCP -0.56 -7.07 -0.4 1.34e-11 Aortic root size; CESC trans rs116095464 0.558 rs6875291 chr5:264192 T/C cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.38e-11 Breast cancer; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg20118385 chr4:4250070 TMEM128 -0.51 -6.15 -0.35 2.78e-9 Gut microbiota (bacterial taxa); CESC cis rs1008375 1.000 rs4642241 chr4:17617111 T/C cg15017067 chr4:17643749 FAM184B 0.39 5.6 0.33 5.22e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7937682 0.632 rs3944619 chr11:111774743 A/G cg22437258 chr11:111473054 SIK2 -0.5 -5.5 -0.32 8.78e-8 Primary sclerosing cholangitis; CESC cis rs12950390 0.853 rs59513807 chr17:45867925 G/A cg00777063 chr17:45855553 NA -0.38 -5.61 -0.33 5.1e-8 IgG glycosylation; CESC cis rs2050392 0.928 rs6481677 chr10:30701816 A/G cg18806716 chr10:30721971 MAP3K8 -0.4 -5.87 -0.34 1.27e-8 Inflammatory bowel disease; CESC cis rs34172651 0.797 rs12920941 chr16:24830866 T/A cg06028605 chr16:24865363 SLC5A11 0.34 5.04 0.3 8.67e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25062357 chr20:2821267 VPS16;FAM113A 0.65 7.7 0.43 2.69e-13 Gut microbiome composition (summer); CESC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC cis rs9905704 0.846 rs302851 chr17:56685424 G/A cg12560992 chr17:57184187 TRIM37 0.62 7.84 0.43 1.11e-13 Testicular germ cell tumor; CESC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.34 5.69 0.33 3.42e-8 Bipolar disorder; CESC cis rs57221529 0.766 rs72706606 chr5:558609 T/C cg09021430 chr5:549028 NA -0.42 -5.26 -0.31 2.92e-7 Lung disease severity in cystic fibrosis; CESC cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg01448562 chr3:133502909 NA -0.58 -8.31 -0.45 5.05e-15 Iron status biomarkers; CESC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg06074448 chr4:187884817 NA -0.47 -7.34 -0.41 2.69e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs950169 0.579 rs12913054 chr15:84664456 A/G cg17507749 chr15:85114479 UBE2QP1 0.61 5.92 0.34 9.94e-9 Schizophrenia; CESC cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9768139 0.901 rs56113702 chr7:158117938 C/T cg06219351 chr7:158114137 PTPRN2 0.48 7.63 0.42 4.31e-13 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04370476 chr3:49761188 GMPPB 0.56 6.47 0.37 4.83e-10 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg23131131 chr22:24373011 LOC391322 -0.65 -8.79 -0.48 1.95e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3749237 0.555 rs2117939 chr3:49415179 C/A cg07636037 chr3:49044803 WDR6 0.59 8.45 0.46 1.98e-15 Resting heart rate; CESC cis rs4595586 0.545 rs17546375 chr12:39407248 C/A cg26384229 chr12:38710491 ALG10B 0.61 8.64 0.47 5.35e-16 Morning vs. evening chronotype; CESC cis rs887829 0.588 rs6715325 chr2:234635241 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.54 -7.47 -0.42 1.2e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs6570726 1.000 rs441477 chr6:145848243 C/T cg05347473 chr6:146136440 FBXO30 0.44 5.96 0.34 7.98e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs12681288 0.676 rs2701910 chr8:1001246 G/T cg04851639 chr8:1020857 NA -0.32 -6.77 -0.38 8.32e-11 Schizophrenia; CESC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4604732 0.631 rs1106719 chr1:247624713 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 -0.57 -7.33 -0.41 2.83e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs17102884 0.506 rs887746 chr14:75403817 C/T cg11812906 chr14:75593930 NEK9 -0.42 -5.21 -0.3 3.84e-7 Neuroticism; CESC cis rs60843830 1.000 rs58461606 chr2:267367 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.89 12.34 0.6 6.07e-28 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1577917 1.000 rs884841 chr6:86680300 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -5.64 -0.33 4.45e-8 Response to antipsychotic treatment; CESC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg11890956 chr21:40555474 PSMG1 1.21 23.16 0.82 1.22e-65 Cognitive function; CESC cis rs2072499 0.778 rs2247476 chr1:156190280 C/A cg24450063 chr1:156163899 SLC25A44 0.9 11.11 0.56 8.37e-24 Testicular germ cell tumor; CESC cis rs9911578 0.935 rs7218105 chr17:57041119 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.96 -0.39 2.66e-11 Intelligence (multi-trait analysis); CESC cis rs137699 0.687 rs4821887 chr22:39756985 C/T cg02038168 chr22:39784481 NA -0.5 -5.69 -0.33 3.41e-8 IgG glycosylation; CESC cis rs4595586 0.545 rs7952765 chr12:39375325 C/G cg26384229 chr12:38710491 ALG10B 0.52 7.31 0.41 3.09e-12 Morning vs. evening chronotype; CESC cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.64 -9.26 -0.49 7.23e-18 Personality dimensions; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg04145264 chr11:65190825 NEAT1 0.45 5.99 0.35 6.64e-9 Tetralogy of Fallot; CESC trans rs1557351 0.723 rs8095898 chr18:54723750 A/C cg11433624 chr6:7146702 RREB1 0.38 6.14 0.35 2.94e-9 Multiple sclerosis (age of onset); CESC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg25517755 chr10:38738941 LOC399744 -0.49 -6.41 -0.37 6.52e-10 Extrinsic epigenetic age acceleration; CESC cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg12386194 chr3:101231763 SENP7 0.61 6.64 0.38 1.75e-10 Colonoscopy-negative controls vs population controls; CESC cis rs10463316 0.894 rs7709994 chr5:150753597 A/T cg03212797 chr5:150827313 SLC36A1 -0.52 -6.83 -0.39 5.78e-11 Metabolite levels (Pyroglutamine); CESC cis rs7539624 0.529 rs7412088 chr1:223899123 T/A cg10100437 chr1:223903862 CAPN2 0.45 5.94 0.34 8.77e-9 Schizophrenia; CESC cis rs9303542 0.559 rs55859232 chr17:46612645 A/G cg04904318 chr17:46607828 HOXB1 -0.6 -5.74 -0.33 2.54e-8 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs3015469 0.671 rs35334347 chr14:51217982 G/A cg26011998 chr14:51135199 SAV1 0.51 5.64 0.33 4.44e-8 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs3087591 0.960 rs2952999 chr17:29509801 G/T cg24425628 chr17:29625626 OMG;NF1 0.44 5.55 0.32 7.1e-8 Hip circumference; CESC cis rs9403521 1.000 rs12208927 chr6:143993634 A/G cg18240653 chr6:144019428 PHACTR2 -0.51 -5.73 -0.33 2.73e-8 Obesity-related traits; CESC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.57 -6.35 -0.36 9.21e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs698833 0.926 rs698827 chr2:44730496 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.53 -6.46 -0.37 4.92e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs644799 0.526 rs534973 chr11:95633624 A/T cg25622487 chr11:95524042 FAM76B;CEP57 0.55 7.4 0.41 1.81e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3126085 1.000 rs11590365 chr1:152165489 C/A cg03465714 chr1:152285911 FLG 0.45 5.05 0.3 8.27e-7 Atopic dermatitis; CESC cis rs7647973 0.925 rs4955439 chr3:49245645 G/T cg07636037 chr3:49044803 WDR6 -0.62 -8.31 -0.45 5e-15 Menarche (age at onset); CESC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg11247378 chr22:39784982 NA -0.59 -8.29 -0.45 5.81e-15 Intelligence (multi-trait analysis); CESC cis rs6701037 0.748 rs11583687 chr1:175132049 A/C cg00321850 chr1:175162397 KIAA0040 0.38 5.73 0.33 2.7e-8 Alcohol dependence; CESC trans rs11165623 0.792 rs6593599 chr1:96911468 C/T cg10631902 chr5:14652156 NA -0.55 -8.17 -0.45 1.3e-14 Hip circumference;Waist circumference; CESC cis rs3026101 0.671 rs8081481 chr17:5282763 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.41 5.48 0.32 9.98e-8 Body mass index; CESC cis rs2732480 0.500 rs12829841 chr12:48628739 A/G cg04545296 chr12:48745243 ZNF641 0.41 6.86 0.39 4.97e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg21918786 chr6:109611834 NA -0.39 -6.04 -0.35 5.08e-9 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07398558 chr1:28879201 TRNAU1AP -0.59 -6.53 -0.37 3.27e-10 Gut microbiome composition (summer); CESC trans rs2658782 0.789 rs56091149 chr11:93073640 A/C cg13657970 chr12:123333035 HIP1R -0.45 -6.04 -0.35 5.27e-9 Pulmonary function decline; CESC cis rs7264396 0.832 rs224416 chr20:34138406 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -7.08 -0.4 1.32e-11 Total cholesterol levels; CESC cis rs10788264 0.544 rs10788269 chr10:124022870 A/G cg09507567 chr10:124027408 NA 0.41 5.56 0.32 6.56e-8 Total body bone mineral density; CESC cis rs1551570 0.755 rs2290687 chr19:10229521 C/T cg16327482 chr19:10226339 EIF3G 0.48 7.76 0.43 1.83e-13 Narcolepsy; CESC cis rs9399135 0.967 rs1014020 chr6:135334426 C/A cg24558204 chr6:135376177 HBS1L 0.52 7.18 0.4 6.82e-12 Red blood cell count; CESC cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg06022373 chr22:39101656 GTPBP1 -0.85 -12.28 -0.6 9.68e-28 Menopause (age at onset); CESC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg04369109 chr6:150039330 LATS1 -0.42 -5.86 -0.34 1.36e-8 Lung cancer; CESC cis rs3767633 0.925 rs4579731 chr1:161766859 G/A cg09175582 chr1:161736000 ATF6 0.8 6.57 0.37 2.59e-10 IgG glycosylation; CESC cis rs7927771 0.542 rs7122217 chr11:47777920 G/C cg20307385 chr11:47447363 PSMC3 -0.58 -8.01 -0.44 3.54e-14 Subjective well-being; CESC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg04166393 chr7:2884313 GNA12 0.59 7.47 0.42 1.14e-12 Height; CESC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg24675658 chr1:53192096 ZYG11B -0.49 -6.09 -0.35 3.92e-9 Monocyte count; CESC cis rs7584330 0.554 rs6760913 chr2:238400702 C/T cg14458575 chr2:238380390 NA 0.77 6.36 0.36 8.89e-10 Prostate cancer; CESC cis rs7429990 0.930 rs71323371 chr3:47945817 A/T cg11946769 chr3:48343235 NME6 0.46 5.62 0.33 4.91e-8 Educational attainment (years of education); CESC cis rs16917546 1.000 rs16917546 chr10:64397538 T/C cg03961010 chr10:64397487 ZNF365 -0.37 -6.09 -0.35 4.01e-9 Basal cell carcinoma; CESC trans rs3749237 0.964 rs2234385 chr3:49846041 G/A cg21659725 chr3:3221576 CRBN 0.53 6.38 0.36 8.01e-10 Resting heart rate; CESC cis rs7084402 0.967 rs1593678 chr10:60291548 A/G cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs4450798 0.739 rs9840302 chr3:13741999 C/T cg23332027 chr3:13681764 NA 0.4 5.31 0.31 2.31e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs17376456 0.877 rs12374488 chr5:93481407 A/G cg21475434 chr5:93447410 FAM172A 0.9 7.77 0.43 1.68e-13 Diabetic retinopathy; CESC cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg11752832 chr7:134001865 SLC35B4 0.53 6.86 0.39 4.82e-11 Mean platelet volume; CESC cis rs7107174 0.901 rs2450138 chr11:77924870 C/T cg02023728 chr11:77925099 USP35 0.49 6.39 0.37 7.56e-10 Testicular germ cell tumor; CESC cis rs10779751 0.690 rs2791646 chr1:11133242 C/T cg08854313 chr1:11322531 MTOR 0.76 10.24 0.53 5.91e-21 Body mass index; CESC trans rs11098499 0.874 rs6822498 chr4:120120183 T/C cg25214090 chr10:38739885 LOC399744 0.61 8.12 0.45 1.83e-14 Corneal astigmatism; CESC trans rs1003719 0.715 rs762139 chr21:38568475 A/T cg17956387 chr1:208418015 PLXNA2 -0.45 -6.38 -0.36 7.95e-10 Eye color traits; CESC cis rs12995491 0.902 rs6737641 chr2:88529471 A/T cg04511125 chr2:88470314 THNSL2 -0.51 -7.36 -0.41 2.35e-12 Response to metformin (IC50); CESC cis rs7605827 0.897 rs13004112 chr2:15604048 C/T cg19274914 chr2:15703543 NA 0.35 6.3 0.36 1.21e-9 Educational attainment (years of education); CESC cis rs1348850 0.872 rs10165785 chr2:178293295 C/T cg23306229 chr2:178417860 TTC30B 0.62 7.92 0.44 6.37e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg22823121 chr1:150693482 HORMAD1 0.47 7.05 0.4 1.6e-11 Tonsillectomy; CESC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg07936489 chr17:37558343 FBXL20 -0.78 -11.38 -0.57 1.08e-24 Glomerular filtration rate (creatinine); CESC cis rs6558174 0.930 rs1038311 chr8:22489247 T/C cg03733263 chr8:22462867 KIAA1967 0.46 6.33 0.36 1.06e-9 Breast cancer; CESC cis rs10883723 0.810 rs1409311 chr10:104282160 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.42 0.41 1.57e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs992157 0.798 rs4996257 chr2:219162836 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.7 9.58 0.51 7.29e-19 Colorectal cancer; CESC cis rs8016982 0.610 rs2371570 chr14:81709686 C/T cg01989461 chr14:81687754 GTF2A1 0.72 11.11 0.56 8.6e-24 Schizophrenia; CESC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg11644478 chr21:40555479 PSMG1 1.03 17.01 0.72 2.21e-44 Cognitive function; CESC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg15145296 chr3:125709740 NA -0.48 -5.28 -0.31 2.76e-7 Blood pressure (smoking interaction); CESC cis rs1008375 1.000 rs4698199 chr4:17656738 G/C cg15017067 chr4:17643749 FAM184B 0.35 5.07 0.3 7.59e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7582720 1.000 rs72926793 chr2:203826396 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs12765878 1.000 rs2902639 chr10:105658588 G/C cg24587175 chr10:105670608 OBFC1 0.33 5.42 0.32 1.31e-7 Coronary artery disease; CESC cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg04455712 chr21:45112962 RRP1B 0.37 5.39 0.31 1.6e-7 Mean corpuscular volume; CESC trans rs4596713 0.538 rs10869961 chr9:71787071 C/T cg16512924 chr15:28394682 HERC2 0.48 6.07 0.35 4.52e-9 Headache; CESC cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg22834771 chr12:69754056 YEATS4 -0.48 -6.35 -0.36 9.41e-10 Blood protein levels; CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg11235426 chr6:292522 DUSP22 -0.72 -9.43 -0.5 2.19e-18 Menopause (age at onset); CESC cis rs1729951 0.546 rs12054219 chr3:136677472 G/A cg25687071 chr3:136751404 NA 0.39 5.1 0.3 6.33e-7 Neuroticism; CESC cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.33 0.31 2.12e-7 Personality dimensions; CESC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg18446336 chr7:2847575 GNA12 -0.37 -5.67 -0.33 3.67e-8 Height; CESC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg08736216 chr1:53307985 ZYG11A -0.39 -6.54 -0.37 3.17e-10 Monocyte count; CESC cis rs7264396 0.677 rs6060553 chr20:34267386 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -10.5 -0.54 8.8e-22 Total cholesterol levels; CESC cis rs763121 0.719 rs138699 chr22:39129708 G/A cg21395723 chr22:39101663 GTPBP1 0.46 5.68 0.33 3.52e-8 Menopause (age at onset); CESC cis rs62005083 1.000 rs62005075 chr14:74476024 A/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.69 5.12 0.3 6.01e-7 Mean corpuscular volume; CESC cis rs116095464 1.000 rs6555160 chr5:311669 A/G cg02160872 chr5:212506 CCDC127 0.6 5.03 0.3 9.19e-7 Breast cancer; CESC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg08470875 chr2:26401718 FAM59B -0.5 -5.05 -0.3 8.17e-7 Gut microbiome composition (summer); CESC cis rs77741769 0.571 rs12831094 chr12:121292704 T/C cg02419362 chr12:121203948 SPPL3 0.34 5.59 0.32 5.6e-8 Mean corpuscular volume; CESC cis rs35110281 0.517 rs11089020 chr21:44939991 C/T cg01579765 chr21:45077557 HSF2BP -0.51 -8.67 -0.47 4.41e-16 Mean corpuscular volume; CESC cis rs1538970 0.924 rs4660855 chr1:45899795 A/G cg24296786 chr1:45957014 TESK2 -0.46 -5.3 -0.31 2.41e-7 Platelet count; CESC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg18350739 chr11:68623251 NA -0.48 -6.99 -0.39 2.22e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1707322 1.000 rs4660905 chr1:46461587 C/T cg03146154 chr1:46216737 IPP -0.72 -9.82 -0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg00784671 chr22:46762841 CELSR1 -0.48 -5.59 -0.32 5.72e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6570726 0.537 rs1280279 chr6:145884048 G/T cg23711669 chr6:146136114 FBXO30 0.88 9.58 0.51 7.35e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs870825 0.616 rs4594761 chr4:185643002 A/C cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs1005277 0.522 rs7090858 chr10:38003670 A/C cg25517755 chr10:38738941 LOC399744 0.39 5.05 0.3 8.29e-7 Extrinsic epigenetic age acceleration; CESC cis rs6088580 0.634 rs6088484 chr20:32985961 T/C cg06115741 chr20:33292138 TP53INP2 -0.47 -6.03 -0.35 5.36e-9 Glomerular filtration rate (creatinine); CESC cis rs17253792 0.545 rs12893061 chr14:56016097 A/T cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs3796352 1.000 rs58660500 chr3:53086573 C/T cg07884673 chr3:53033167 SFMBT1 0.67 5.75 0.33 2.44e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs7586879 0.616 rs916485 chr2:25082273 T/C cg01884057 chr2:25150051 NA 0.37 7.24 0.41 4.89e-12 Body mass index; CESC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg09263875 chr16:632152 PIGQ 0.69 11.97 0.59 1.09e-26 Height; CESC cis rs2797160 1.000 rs9401843 chr6:126004124 T/C cg05901451 chr6:126070800 HEY2 -0.46 -6.62 -0.38 1.94e-10 Endometrial cancer; CESC trans rs801193 1.000 rs10234018 chr7:66146284 A/T cg26939375 chr7:64535504 NA -0.66 -8.99 -0.48 4.77e-17 Aortic root size; CESC cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg17211192 chr8:82754475 SNX16 -0.58 -7.42 -0.41 1.62e-12 Diastolic blood pressure; CESC cis rs1568889 0.877 rs12786351 chr11:28271122 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.69 7.02 0.4 1.82e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12070509 chr1:222638775 NA 0.57 6.06 0.35 4.74e-9 Gut microbiome composition (summer); CESC trans rs9858542 1.000 rs13085791 chr3:49721798 C/A cg21659725 chr3:3221576 CRBN -0.54 -6.71 -0.38 1.21e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg18715318 chr22:19420067 HIRA;MRPL40 -0.48 -6.04 -0.35 5.14e-9 Subjective well-being; CESC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg16325326 chr1:53192061 ZYG11B -0.53 -7.87 -0.44 8.92e-14 Monocyte count; CESC cis rs6504950 0.566 rs12937360 chr17:53046298 C/T cg19360675 chr17:53046073 COX11;STXBP4 0.43 5.49 0.32 9.53e-8 Breast cancer; CESC cis rs2228479 0.867 rs62052185 chr16:89969254 C/T cg04013166 chr16:89971882 TCF25 0.79 7.12 0.4 1.02e-11 Skin colour saturation; CESC cis rs7520050 0.966 rs11579634 chr1:46466391 A/G cg24296786 chr1:45957014 TESK2 -0.42 -5.16 -0.3 4.96e-7 Red blood cell count;Reticulocyte count; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23191292 chr6:157099924 ARID1B -0.47 -6.04 -0.35 5.23e-9 Height; CESC cis rs2479106 0.549 rs1975063 chr9:126397433 C/T cg16191174 chr9:126692580 DENND1A 0.38 5.2 0.3 3.99e-7 Polycystic ovary syndrome; CESC cis rs2816062 0.965 rs2816061 chr1:18903819 A/G cg18795169 chr1:18902165 NA 0.87 15.78 0.7 5.09e-40 Urate levels in lean individuals; CESC cis rs116095464 0.867 rs7726582 chr5:215349 C/G cg22496380 chr5:211416 CCDC127 -0.7 -8.09 -0.45 2.11e-14 Breast cancer; CESC cis rs3820928 0.874 rs10169717 chr2:227796911 T/G cg05526886 chr2:227700861 RHBDD1 -0.4 -5.1 -0.3 6.49e-7 Pulmonary function; CESC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg24733560 chr20:60626293 TAF4 0.45 6.34 0.36 9.97e-10 Body mass index; CESC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.41 6.22 0.36 1.89e-9 Cystic fibrosis severity; CESC cis rs5750830 0.645 rs756640 chr22:39779300 G/A cg24399712 chr22:39784796 NA -0.73 -10.61 -0.55 3.81e-22 Intelligence (multi-trait analysis); CESC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg10691866 chr7:65817282 TPST1 -0.32 -5.45 -0.32 1.15e-7 Aortic root size; CESC cis rs2645694 0.626 rs2703136 chr4:77828957 T/A cg18351406 chr4:77819688 ANKRD56 0.52 6.32 0.36 1.1e-9 Emphysema distribution in smoking; CESC cis rs9831754 0.906 rs2314196 chr3:78411050 C/T cg06138941 chr3:78371609 NA -0.52 -6.89 -0.39 4.14e-11 Calcium levels; CESC cis rs17376456 0.877 rs10044066 chr5:93437580 T/C cg21475434 chr5:93447410 FAM172A 0.82 7.54 0.42 7.63e-13 Diabetic retinopathy; CESC cis rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09720205 chr16:57508738 DOK4 0.36 5.19 0.3 4.1e-7 Gambling; CESC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.05 -0.35 4.89e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs55728055 0.661 rs9619217 chr22:32043611 A/G cg01338084 chr22:32026380 PISD 1.22 8.56 0.47 9.19e-16 Age-related hearing impairment; CESC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg04025307 chr7:1156635 C7orf50 0.36 5.6 0.33 5.22e-8 Longevity;Endometriosis; CESC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg18252515 chr7:66147081 NA 0.39 5.08 0.3 7.05e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15419852 chr19:39897474 ZFP36 0.54 6.06 0.35 4.72e-9 Gut microbiome composition (summer); CESC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg18225595 chr11:63971243 STIP1 -0.52 -7.36 -0.41 2.29e-12 Platelet count; CESC cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg15506890 chr2:3487001 NA -0.48 -6.12 -0.35 3.33e-9 Neurofibrillary tangles; CESC cis rs3736485 0.934 rs28648597 chr15:51856066 T/A cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg08968635 chr6:28129556 ZNF389 0.41 5.28 0.31 2.68e-7 Depression; CESC cis rs4237845 0.537 rs59401446 chr12:58259564 G/A cg00677455 chr12:58241039 CTDSP2 0.79 10.7 0.55 1.88e-22 Intelligence (multi-trait analysis); CESC cis rs7959452 0.640 rs4274230 chr12:69700772 T/G cg14784868 chr12:69753453 YEATS4 0.73 10.44 0.54 1.38e-21 Blood protein levels; CESC cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.45 0.42 1.34e-12 Tonsillectomy; CESC cis rs3747547 0.892 rs67076718 chr9:38035758 C/T cg13774184 chr9:37916125 SHB -0.7 -5.83 -0.34 1.6e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs1552244 0.554 rs17050704 chr3:10045734 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.61 7.88 0.44 8.63e-14 Alzheimer's disease; CESC cis rs9287719 0.967 rs7608498 chr2:10738428 G/A cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs12477438 1.000 rs12477438 chr2:99841085 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.69 -8.21 -0.45 9.96e-15 Chronic sinus infection; CESC cis rs858239 0.600 rs7790157 chr7:23126998 G/A cg23682824 chr7:23144976 KLHL7 0.55 7.67 0.43 3.39e-13 Cerebrospinal fluid biomarker levels; CESC cis rs2933343 0.729 rs789230 chr3:128602558 G/A cg25356066 chr3:128598488 ACAD9 0.66 9.18 0.49 1.27e-17 IgG glycosylation; CESC cis rs763512 0.532 rs3110626 chr17:35896402 A/G cg16670864 chr17:35848621 DUSP14 -0.44 -5.46 -0.32 1.11e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs2204008 0.660 rs2874343 chr12:38239096 C/T cg13010199 chr12:38710504 ALG10B 0.52 6.43 0.37 5.91e-10 Bladder cancer; CESC cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg18769074 chr3:133464867 TF 0.29 5.38 0.31 1.63e-7 Iron status biomarkers; CESC cis rs4589502 1.000 rs80263963 chr15:67127228 C/T cg12317470 chr15:67143691 NA 0.69 5.31 0.31 2.38e-7 Lung cancer (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09835421 chr16:68378352 PRMT7 -0.56 -6.25 -0.36 1.65e-9 Gut microbiome composition (summer); CESC cis rs72945132 0.562 rs7951959 chr11:70234272 A/G cg00319359 chr11:70116639 PPFIA1 0.71 6.87 0.39 4.45e-11 Coronary artery disease; CESC cis rs914615 0.508 rs4971079 chr1:155130391 C/T cg02153340 chr1:155202674 NA -0.37 -5.44 -0.32 1.19e-7 Urinary albumin-to-creatinine ratio; CESC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg22920501 chr2:26401640 FAM59B -0.91 -10.33 -0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs826838 0.967 rs826858 chr12:39116731 A/G cg26384229 chr12:38710491 ALG10B -0.67 -11.02 -0.56 1.72e-23 Heart rate; CESC cis rs911555 0.617 rs7156036 chr14:103908142 A/G cg24130564 chr14:104152367 KLC1 0.5 6.5 0.37 4.05e-10 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27158084 chr6:149813350 NA -0.58 -6.99 -0.39 2.2e-11 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03672602 chr19:19754555 GMIP 0.45 6.0 0.35 6.56e-9 Systemic lupus erythematosus; CESC trans rs60380162 0.963 rs4278349 chr1:87725833 C/T cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.03 -0.35 5.48e-9 Loneliness (linear analysis); CESC cis rs17608059 0.901 rs11078215 chr17:13906934 T/C cg11395062 chr17:14139857 CDRT15 0.5 5.9 0.34 1.1e-8 Temperament; CESC cis rs7829975 0.514 rs2945873 chr8:8260445 C/T cg08975724 chr8:8085496 FLJ10661 0.41 5.21 0.3 3.82e-7 Mood instability; CESC cis rs2573652 0.722 rs11852383 chr15:100542765 C/T cg09918751 chr15:100517450 ADAMTS17 -0.34 -6.33 -0.36 1.05e-9 Height; CESC cis rs400736 0.930 rs225119 chr1:8044361 T/C cg25007680 chr1:8021821 PARK7 0.72 10.22 0.53 7.16e-21 Response to antidepressants and depression; CESC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg18200150 chr17:30822561 MYO1D 0.65 9.74 0.51 2.3e-19 Schizophrenia; CESC cis rs10097731 0.901 rs7823749 chr8:82047828 C/A cg25230327 chr8:82042993 NA -0.5 -5.33 -0.31 2.14e-7 Serum total protein level; CESC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.3 -0.36 1.2e-9 Total body bone mineral density; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg19969431 chr14:74321094 PTGR2 0.41 6.21 0.36 2.03e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs3741404 0.791 rs7112960 chr11:63907079 A/G cg15268290 chr11:83690587 DLG2 0.43 6.04 0.35 5.23e-9 Platelet count; CESC cis rs2204008 0.515 rs11495471 chr12:38027178 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.63 0.38 1.87e-10 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04791456 chr3:57505743 DNAH12 -0.62 -6.77 -0.38 8.04e-11 Gut microbiome composition (summer); CESC cis rs1348850 0.574 rs13431105 chr2:178434674 A/G cg23306229 chr2:178417860 TTC30B 0.8 6.97 0.39 2.55e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs684232 0.835 rs12450003 chr17:519015 T/C cg15660573 chr17:549704 VPS53 -0.43 -5.7 -0.33 3.2e-8 Prostate cancer; CESC cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg06212747 chr3:49208901 KLHDC8B 0.71 9.31 0.5 4.93e-18 Parkinson's disease; CESC cis rs6142102 0.580 rs9753679 chr20:32540860 G/A cg08999081 chr20:33150536 PIGU 0.34 5.17 0.3 4.61e-7 Skin pigmentation; CESC cis rs727505 1.000 rs66513837 chr7:124492763 A/G cg23710748 chr7:124431027 NA -0.48 -7.61 -0.42 4.76e-13 Lewy body disease; CESC cis rs4660306 0.961 rs937290 chr1:45961955 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.86e-13 Homocysteine levels; CESC cis rs5758659 0.935 rs134879 chr22:42664201 A/C cg04733989 chr22:42467013 NAGA 0.42 5.88 0.34 1.23e-8 Cognitive function; CESC cis rs1904096 0.506 rs28701470 chr4:95167088 A/C cg11021082 chr4:95130006 SMARCAD1 -0.63 -10.06 -0.53 2.19e-20 Type 2 diabetes; CESC cis rs7267979 1.000 rs6107033 chr20:25363591 A/G cg08601574 chr20:25228251 PYGB -0.36 -5.2 -0.3 4.01e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs11031096 0.678 rs970329 chr11:4189803 G/T cg18678763 chr11:4115507 RRM1 -0.4 -5.18 -0.3 4.46e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs6032067 0.777 rs2868235 chr20:43794069 T/C cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs6540559 0.673 rs6698154 chr1:210007777 A/G cg21951975 chr1:209979733 IRF6 0.58 7.04 0.4 1.61e-11 Cleft lip with or without cleft palate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09423610 chr7:902986 UNC84A 0.46 6.46 0.37 5.07e-10 Fibrinogen levels; CESC cis rs963731 0.579 rs997344 chr2:39281730 G/C cg04010122 chr2:39346883 SOS1 -0.73 -5.86 -0.34 1.34e-8 Corticobasal degeneration; CESC cis rs3813567 0.759 rs12595350 chr15:78953464 G/A cg05914723 chr15:78953907 NA 0.46 5.85 0.34 1.48e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs7208859 0.573 rs28779471 chr17:29084369 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3815700 1.000 rs7248273 chr19:33096816 C/T cg02997394 chr19:33096574 ANKRD27 0.69 6.86 0.39 4.97e-11 Eosinophilic esophagitis; CESC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg11764359 chr7:65958608 NA 0.94 14.74 0.67 2.64e-36 Aortic root size; CESC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.73 -9.27 -0.5 6.52e-18 Alzheimer's disease; CESC cis rs10447248 0.776 rs7447161 chr5:107899940 T/C cg25075504 chr5:107899390 NA -0.38 -5.54 -0.32 7.29e-8 Adiponectin levels; CESC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.64 0.43 3.85e-13 Prudent dietary pattern; CESC cis rs881375 0.967 rs7039505 chr9:123705945 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 5.25 0.31 3.13e-7 Rheumatoid arthritis; CESC cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.13 0.3 5.54e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2688608 0.592 rs12253429 chr10:75496161 C/G cg23231163 chr10:75533350 FUT11 -0.35 -5.28 -0.31 2.68e-7 Inflammatory bowel disease; CESC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg06808227 chr14:105710500 BRF1 -0.6 -6.87 -0.39 4.44e-11 Mean platelet volume;Platelet distribution width; CESC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -5.71 -0.33 3.07e-8 Extrinsic epigenetic age acceleration; CESC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg27286337 chr10:134555280 INPP5A 0.61 6.95 0.39 2.81e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs11098499 0.754 rs12711071 chr4:120240934 A/G cg09307838 chr4:120376055 NA 0.8 10.76 0.55 1.18e-22 Corneal astigmatism; CESC cis rs2439831 0.850 rs12101756 chr15:44053887 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.7 8.06 0.44 2.71e-14 Lung cancer in ever smokers; CESC cis rs116095464 0.558 rs6878087 chr5:223117 C/T cg10591111 chr5:226296 SDHA 0.46 5.84 0.34 1.55e-8 Breast cancer; CESC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg09359103 chr1:154839909 KCNN3 -0.66 -12.33 -0.6 6.72e-28 Prostate cancer; CESC cis rs2243480 0.901 rs778732 chr7:65822360 C/T cg18252515 chr7:66147081 NA -1.37 -13.3 -0.63 2.87e-31 Diabetic kidney disease; CESC trans rs5769765 0.773 rs9616208 chr22:50313359 G/A cg09872104 chr7:134855509 C7orf49 -0.55 -6.2 -0.36 2.14e-9 Schizophrenia; CESC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg11644478 chr21:40555479 PSMG1 1.04 17.85 0.74 2.41e-47 Cognitive function; CESC cis rs2731664 0.792 rs2545795 chr5:176887106 A/C cg23176889 chr5:176863531 GRK6 -0.64 -11.3 -0.57 2.02e-24 Intelligence (multi-trait analysis); CESC cis rs698833 0.828 rs6745281 chr2:44534472 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 6.26 0.36 1.56e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13787782 chr2:239161568 PER2 0.47 6.3 0.36 1.22e-9 Fibrinogen levels; CESC cis rs9914988 0.943 rs9915673 chr17:27132893 G/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs4423214 0.840 rs1619577 chr11:71181485 C/T cg05163923 chr11:71159392 DHCR7 -0.65 -7.77 -0.43 1.71e-13 Vitamin D levels; CESC cis rs1707322 0.928 rs6681068 chr1:46398382 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs939574 0.722 rs72955435 chr2:220087354 A/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.89 7.23 0.41 5.27e-12 Platelet distribution width; CESC cis rs1707322 0.964 rs12067716 chr1:46434428 T/A cg05343316 chr1:45956843 TESK2 0.5 6.11 0.35 3.48e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs1527517 chr4:98931907 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg08968635 chr6:28129556 ZNF389 0.41 5.37 0.31 1.76e-7 Depression; CESC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7607369 0.574 rs12990478 chr2:219667463 T/A cg02176678 chr2:219576539 TTLL4 -0.35 -6.12 -0.35 3.33e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs1355223 0.583 rs2941058 chr11:34880245 C/G cg24088639 chr11:34937564 PDHX;APIP -0.4 -5.06 -0.3 7.8e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg23758822 chr17:41437982 NA -1.02 -17.3 -0.73 2.13e-45 Menopause (age at onset); CESC cis rs7789940 0.904 rs7459185 chr7:75934640 C/G cg10167463 chr7:75959203 YWHAG 0.42 5.1 0.3 6.42e-7 Multiple sclerosis; CESC cis rs7202877 0.706 rs42472 chr16:75473320 T/A cg04384234 chr16:75411784 CFDP1 0.5 5.97 0.34 7.54e-9 Type 2 diabetes;Type 1 diabetes; CESC cis rs3733585 0.673 rs6449156 chr4:9956712 G/C cg02734326 chr4:10020555 SLC2A9 -0.42 -5.94 -0.34 8.96e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9488822 0.676 rs1999929 chr6:116381994 T/C cg15226275 chr6:116381976 FRK 0.26 6.52 0.37 3.55e-10 Cholesterol, total;LDL cholesterol; CESC cis rs4692589 0.965 rs7657455 chr4:170958843 C/G cg19918862 chr4:170955249 NA 0.36 5.9 0.34 1.13e-8 Anxiety disorder; CESC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg14983838 chr19:29218262 NA 0.5 6.16 0.35 2.67e-9 Methadone dose in opioid dependence; CESC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg00149659 chr3:10157352 C3orf10 0.66 7.6 0.42 4.98e-13 Alzheimer's disease; CESC trans rs9325144 0.647 rs11169258 chr12:39113040 C/T cg23762105 chr12:34175262 ALG10 0.47 6.19 0.36 2.32e-9 Morning vs. evening chronotype; CESC cis rs3540 0.597 rs11639150 chr15:91042071 C/G cg10434728 chr15:90938212 IQGAP1 -0.42 -7.62 -0.42 4.44e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg15017067 chr4:17643749 FAM184B 0.37 5.21 0.3 3.74e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9400271 0.632 rs9374070 chr6:109586455 G/A cg01475377 chr6:109611718 NA -0.46 -7.12 -0.4 9.98e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs3733585 0.673 rs4407505 chr4:9953367 T/G cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg17143192 chr8:8559678 CLDN23 0.74 8.68 0.47 4.19e-16 Obesity-related traits; CESC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.53 -0.37 3.33e-10 Bipolar disorder; CESC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg05564831 chr3:52568323 NT5DC2 0.4 6.18 0.36 2.36e-9 Electroencephalogram traits; CESC cis rs2790457 0.958 rs1265829 chr10:28911303 T/C cg04045419 chr10:28823091 WAC -0.42 -5.05 -0.3 8.2e-7 Multiple myeloma; CESC cis rs2050392 0.624 rs303444 chr10:30729347 C/T cg18806716 chr10:30721971 MAP3K8 -0.63 -9.46 -0.5 1.79e-18 Inflammatory bowel disease; CESC cis rs7208859 0.573 rs7214313 chr17:29138596 T/C cg19761014 chr17:28927070 LRRC37B2 0.73 6.16 0.35 2.71e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg20476274 chr7:133979776 SLC35B4 0.62 8.89 0.48 9.92e-17 Mean platelet volume; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23879496 chr6:43749477 VEGFA -0.46 -6.35 -0.36 9.55e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9457247 0.967 rs388406 chr6:167409562 A/G cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.72e-8 Crohn's disease; CESC cis rs873946 0.564 rs2803991 chr10:134557068 A/G cg18305652 chr10:134549665 INPP5A 0.49 7.6 0.42 5.24e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs12142240 0.698 rs66575205 chr1:46814092 T/G cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg00166722 chr3:10149974 C3orf24 0.46 5.67 0.33 3.8e-8 Alzheimer's disease; CESC cis rs9486719 1.000 rs2499804 chr6:96861216 A/G cg06623918 chr6:96969491 KIAA0776 0.78 8.15 0.45 1.44e-14 Migraine;Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02071454 chr1:213446482 RPS6KC1 -0.7 -8.02 -0.44 3.37e-14 Gut microbiome composition (summer); CESC cis rs6582630 0.555 rs34145279 chr12:38405588 T/C cg26384229 chr12:38710491 ALG10B 0.73 10.79 0.55 9.99e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg18252515 chr7:66147081 NA 0.46 6.0 0.35 6.54e-9 Aortic root size; CESC cis rs7107174 0.681 rs10793301 chr11:78020913 G/T cg02023728 chr11:77925099 USP35 0.48 6.27 0.36 1.46e-9 Testicular germ cell tumor; CESC cis rs360798 0.532 rs2136737 chr2:62969310 G/C cg17519650 chr2:63277830 OTX1 -0.54 -6.87 -0.39 4.53e-11 Coronary artery disease; CESC cis rs9399135 0.967 rs9376075 chr6:135296963 A/G cg24558204 chr6:135376177 HBS1L 0.5 6.75 0.38 9.09e-11 Red blood cell count; CESC cis rs7223966 1.000 rs11871767 chr17:61698723 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.56 0.37 2.82e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg08888203 chr3:10149979 C3orf24 0.53 6.72 0.38 1.11e-10 Alzheimer's disease; CESC cis rs3008870 0.959 rs2815353 chr1:67483372 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.01 13.78 0.65 5.96e-33 Lymphocyte percentage of white cells; CESC trans rs1728785 0.818 rs1645984 chr16:68628850 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.7 7.98 0.44 4.59e-14 Ulcerative colitis; CESC cis rs10851478 0.872 rs2899434 chr15:49766968 G/A cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.16 0.3 4.79e-7 Oral cavity cancer; CESC cis rs7904985 0.889 rs1078789 chr10:88110247 C/T cg07322936 chr10:88137208 NA -0.4 -5.32 -0.31 2.24e-7 Barrett's esophagus; CESC cis rs1044826 0.692 rs295484 chr3:139231782 A/G cg00490450 chr3:139108681 COPB2 -0.41 -5.19 -0.3 4.19e-7 Obesity-related traits; CESC cis rs548181 0.668 rs540555 chr11:125486848 T/C cg03464685 chr11:125439445 EI24 0.91 8.01 0.44 3.76e-14 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6964587 1.000 rs17164263 chr7:91581566 T/A cg17063962 chr7:91808500 NA -0.57 -7.68 -0.43 3.06e-13 Breast cancer; CESC cis rs4472734 1.000 rs11120328 chr1:214628200 G/A cg00063699 chr1:214624242 PTPN14 -0.33 -5.08 -0.3 7.25e-7 Height; CESC cis rs10979 0.965 rs9496679 chr6:143896741 G/T cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs1348850 0.567 rs3770005 chr2:178528874 A/G cg22681709 chr2:178499509 PDE11A -0.5 -8.05 -0.44 2.76e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg04248312 chr19:17393744 ANKLE1 -0.93 -15.23 -0.68 4.67e-38 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg05340658 chr4:99064831 C4orf37 0.79 12.28 0.6 9.45e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9549367 0.789 rs12866090 chr13:113869410 G/A cg18105134 chr13:113819100 PROZ -0.73 -9.5 -0.5 1.33e-18 Platelet distribution width; CESC cis rs12618769 0.597 rs1961651 chr2:99049674 G/C cg10123293 chr2:99228465 UNC50 0.41 5.42 0.32 1.31e-7 Bipolar disorder; CESC trans rs2207136 0.868 rs12209596 chr6:50841472 C/T cg06522515 chr3:184090630 THPO -0.39 -6.8 -0.39 6.84e-11 Myopia; CESC cis rs909674 0.818 rs8136980 chr22:39844574 G/A cg02038168 chr22:39784481 NA -0.66 -8.25 -0.45 7.36e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7224314 0.895 rs11654663 chr17:65389305 A/C cg01507342 chr17:65387096 PITPNC1 -0.47 -5.78 -0.33 2.04e-8 Diisocyanate-induced asthma; CESC cis rs10276381 0.786 rs73300665 chr7:28227024 G/A cg23620719 chr7:28220237 JAZF1 0.83 8.97 0.48 5.68e-17 Crohn's disease; CESC trans rs1814175 0.817 rs28525029 chr11:50045815 A/G cg15704280 chr7:45808275 SEPT13 -1.05 -21.42 -0.8 9.36e-60 Height; CESC cis rs7192380 0.639 rs7186296 chr16:69808998 A/G cg15192750 chr16:69999425 NA -0.37 -5.03 -0.3 8.91e-7 Sjögren's syndrome; CESC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg13628971 chr7:2884303 GNA12 0.64 8.78 0.47 2.11e-16 Height; CESC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2625529 0.557 rs7496582 chr15:72147831 T/G cg16672083 chr15:72433130 SENP8 -0.38 -5.66 -0.33 3.97e-8 Red blood cell count; CESC cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.69 -10.89 -0.56 4.48e-23 Personality dimensions; CESC cis rs17376456 0.877 rs10061080 chr5:93420559 A/G cg25358565 chr5:93447407 FAM172A 1.16 11.74 0.58 6.68e-26 Diabetic retinopathy; CESC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg17376030 chr22:41985996 PMM1 0.68 7.43 0.42 1.46e-12 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10546176 chr5:34929404 DNAJC21 0.61 6.62 0.38 2.02e-10 Gut microbiome composition (summer); CESC cis rs17401966 0.838 rs946501 chr1:10309580 C/G cg15208524 chr1:10270712 KIF1B 0.4 5.18 0.3 4.45e-7 Hepatocellular carcinoma; CESC cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.47 0.46 1.72e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6580649 0.941 rs7963934 chr12:48477086 C/G cg24011408 chr12:48396354 COL2A1 -0.4 -5.04 -0.3 8.67e-7 Lung cancer; CESC cis rs11098499 0.820 rs6534140 chr4:120455311 C/T cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.24e-28 Corneal astigmatism; CESC cis rs854765 0.583 rs4925129 chr17:17807186 A/G cg09796270 chr17:17721594 SREBF1 0.46 6.29 0.36 1.32e-9 Total body bone mineral density; CESC cis rs8078723 0.966 rs7021 chr17:38153875 T/A cg17467752 chr17:38218738 THRA 0.68 10.19 0.53 8.65e-21 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg07677032 chr17:61819896 STRADA -0.46 -6.18 -0.35 2.41e-9 Prudent dietary pattern; CESC cis rs4595586 0.545 rs7136002 chr12:39369168 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.79 -10.27 -0.53 4.9e-21 Height; CESC cis rs3749237 0.636 rs1568662 chr3:49521263 A/G cg03060546 chr3:49711283 APEH 0.77 11.7 0.58 8.95e-26 Resting heart rate; CESC cis rs4253772 0.591 rs6008361 chr22:46652372 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.69 -8.14 -0.45 1.55e-14 LDL cholesterol;Cholesterol, total; CESC cis rs7364180 0.582 rs139568 chr22:42210985 C/T cg03806693 chr22:41940476 POLR3H 0.5 6.06 0.35 4.57e-9 Alzheimer's disease biomarkers; CESC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg23281280 chr6:28129359 ZNF389 0.6 8.0 0.44 3.86e-14 Depression; CESC cis rs78456975 1.000 rs11898988 chr2:1560336 G/A cg01028140 chr2:1542097 TPO -0.5 -5.37 -0.31 1.69e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7560272 0.682 rs2421546 chr2:73641077 A/C cg20560298 chr2:73613845 ALMS1 0.5 7.16 0.4 7.74e-12 Schizophrenia; CESC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg18225595 chr11:63971243 STIP1 0.51 5.13 0.3 5.58e-7 Attention deficit hyperactivity disorder; CESC cis rs6681460 1.000 rs9662943 chr1:67121132 A/G cg02459107 chr1:67143332 SGIP1 -0.37 -5.42 -0.32 1.36e-7 Presence of antiphospholipid antibodies; CESC cis rs6502050 0.835 rs12938965 chr17:80128646 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.97e-7 Life satisfaction; CESC cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg20476274 chr7:133979776 SLC35B4 0.66 9.64 0.51 4.63e-19 Mean platelet volume; CESC cis rs12291225 0.679 rs11023170 chr11:14294909 A/G cg19336497 chr11:14380999 RRAS2 -0.37 -5.27 -0.31 2.76e-7 Sense of smell; CESC cis rs12477438 1.000 rs12466388 chr2:99916538 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -7.84 -0.43 1.13e-13 Chronic sinus infection; CESC cis rs9611565 0.694 rs5758324 chr22:41787950 G/T cg06634786 chr22:41940651 POLR3H -0.45 -5.24 -0.31 3.3e-7 Vitiligo; CESC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.92 9.75 0.51 2.16e-19 Mean platelet volume; CESC cis rs11638352 1.000 rs4924727 chr15:44280609 T/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.51 -5.16 -0.3 4.84e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs3820928 0.874 rs12614648 chr2:227785535 G/A cg05526886 chr2:227700861 RHBDD1 -0.46 -5.89 -0.34 1.16e-8 Pulmonary function; CESC cis rs73206853 0.698 rs59574270 chr12:111112098 A/C cg12870014 chr12:110450643 ANKRD13A 0.66 5.48 0.32 9.67e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg03452623 chr4:187889614 NA -0.83 -14.22 -0.66 1.8e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg02931644 chr1:25747376 RHCE 0.39 6.63 0.38 1.91e-10 Erythrocyte sedimentation rate; CESC cis rs12545109 0.800 rs973548 chr8:57416402 C/T cg09654669 chr8:57350985 NA -0.45 -6.22 -0.36 1.88e-9 Obesity-related traits; CESC trans rs7945705 0.935 rs2653593 chr11:8877317 G/A cg10637292 chr12:52960529 KRT74 0.36 6.25 0.36 1.59e-9 Hemoglobin concentration; CESC cis rs7520050 0.645 rs1768809 chr1:46502836 A/C cg03146154 chr1:46216737 IPP -0.54 -7.18 -0.4 7.22e-12 Red blood cell count;Reticulocyte count; CESC trans rs11098499 0.618 rs6858383 chr4:120296772 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs3768617 0.510 rs7414273 chr1:183075017 T/C ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.05e-34 Fuchs's corneal dystrophy; CESC cis rs2072732 0.821 rs10909868 chr1:2962207 A/C cg15211996 chr1:2936768 ACTRT2 0.31 5.53 0.32 7.59e-8 Plateletcrit; CESC trans rs6794880 0.778 rs1125601 chr3:84438338 A/T cg03554283 chr8:76319451 NA -0.56 -5.99 -0.35 6.66e-9 Body mass index (joint analysis main effects and smoking interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.59 0.32 5.64e-8 Hip circumference adjusted for BMI; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17818798 chr19:14228473 PRKACA -0.44 -6.04 -0.35 5.29e-9 Ulcerative colitis; CESC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg04369109 chr6:150039330 LATS1 -0.4 -5.44 -0.32 1.19e-7 Lung cancer; CESC cis rs10754283 0.934 rs6428563 chr1:90111583 T/A cg21401794 chr1:90099060 LRRC8C 0.7 9.42 0.5 2.27e-18 Amyotrophic lateral sclerosis (sporadic); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg08167039 chr1:762232 NCRNA00115;LOC643837 -0.5 -6.59 -0.38 2.35e-10 Height; CESC cis rs3213545 0.659 rs2259690 chr12:121457914 T/G cg25281562 chr12:121454272 C12orf43 0.45 5.69 0.33 3.3e-8 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs1670533 1.000 rs629260 chr4:1086764 A/G cg04106633 chr4:1044584 NA 0.4 5.08 0.3 6.98e-7 Recombination rate (females); CESC cis rs4253772 0.530 rs9615958 chr22:46751122 A/G cg18190219 chr22:46762943 CELSR1 -0.63 -6.24 -0.36 1.72e-9 LDL cholesterol;Cholesterol, total; CESC cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2737618 0.551 rs2816992 chr1:200069216 C/T cg21825944 chr1:200113062 NR5A2 0.35 5.17 0.3 4.55e-7 Uric acid levels; CESC cis rs2228479 1.000 rs62052213 chr16:89991963 C/T cg06558623 chr16:89946397 TCF25 1.17 9.0 0.48 4.39e-17 Skin colour saturation; CESC cis rs75804782 0.521 rs56340711 chr2:239440080 A/T cg18131467 chr2:239335373 ASB1 -0.7 -5.59 -0.32 5.74e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs2635047 0.565 rs2668759 chr18:44693711 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 5.88 0.34 1.23e-8 Educational attainment; CESC cis rs1062177 0.756 rs2964592 chr5:151115688 A/G cg00977110 chr5:151150581 G3BP1 -0.52 -5.56 -0.32 6.6e-8 Preschool internalizing problems; CESC trans rs3942852 0.868 rs6485808 chr11:48109151 A/G cg15704280 chr7:45808275 SEPT13 -0.67 -7.07 -0.4 1.34e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs7662987 1.000 rs28730587 chr4:100004341 C/T cg13256891 chr4:100009986 ADH5 -0.73 -5.23 -0.31 3.39e-7 Smoking initiation; CESC cis rs10779751 1.000 rs2076655 chr1:11289161 A/G cg08854313 chr1:11322531 MTOR -0.92 -14.52 -0.67 1.48e-35 Body mass index; CESC cis rs1348850 0.526 rs6433672 chr2:178378175 G/T cg22681709 chr2:178499509 PDE11A -0.49 -5.24 -0.31 3.24e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7107174 1.000 rs1893447 chr11:77973182 A/G cg02023728 chr11:77925099 USP35 0.39 5.66 0.33 4e-8 Testicular germ cell tumor; CESC cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg02297831 chr4:17616191 MED28 0.49 6.15 0.35 2.81e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1008375 0.932 rs7677212 chr4:17675932 A/G cg16339924 chr4:17578868 LAP3 -0.58 -6.91 -0.39 3.62e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg15445000 chr17:37608096 MED1 -0.41 -6.8 -0.39 6.8e-11 Glomerular filtration rate (creatinine); CESC cis rs1670533 0.932 rs3796620 chr4:1095079 A/G cg27284194 chr4:1044797 NA -0.47 -6.01 -0.35 6.08e-9 Recombination rate (females); CESC cis rs362272 0.545 rs2239725 chr4:3305739 C/T cg08886695 chr4:3369023 RGS12 -0.39 -5.15 -0.3 5.2e-7 Serum sulfate level; CESC cis rs2412459 1.000 rs8023482 chr15:40307095 A/C cg10636054 chr15:40330586 SRP14 0.68 5.49 0.32 9.44e-8 Response to haloperidol in psychosis; CESC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg16325326 chr1:53192061 ZYG11B -0.89 -15.32 -0.69 2.26e-38 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00531924 chr6:111279890 GTF3C6 0.52 6.02 0.35 5.65e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs5753618 0.509 rs5749224 chr22:31558549 C/T cg13145458 chr22:31556086 RNF185 0.46 5.18 0.3 4.39e-7 Colorectal cancer; CESC cis rs763014 1.000 rs763014 chr16:675680 T/C cg07256732 chr16:621771 PIGQ -0.32 -5.49 -0.32 9.36e-8 Height; CESC cis rs9457247 1.000 rs2769354 chr6:167379771 G/T cg23791538 chr6:167370224 RNASET2 0.6 8.57 0.47 8.75e-16 Crohn's disease; CESC cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -12.48 -0.61 2.03e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs703842 0.585 rs10877022 chr12:58223937 A/G cg02175503 chr12:58329896 NA 0.48 5.78 0.33 2.13e-8 Multiple sclerosis; CESC cis rs7937682 0.575 rs7114617 chr11:111768173 A/T cg09085632 chr11:111637200 PPP2R1B 0.91 11.81 0.59 3.87e-26 Primary sclerosing cholangitis; CESC cis rs4835473 0.900 rs35311036 chr4:144655550 T/A cg25736465 chr4:144833511 NA -0.33 -5.15 -0.3 5.14e-7 Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18269826 chr15:101459483 LRRK1 0.51 6.3 0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs6502050 0.835 rs7502078 chr17:80131879 C/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.3 -0.31 2.41e-7 Life satisfaction; CESC cis rs4595586 0.545 rs4768526 chr12:39402898 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.63 0.33 4.61e-8 Morning vs. evening chronotype; CESC cis rs9640161 0.750 rs1983440 chr7:150023941 G/C cg10018233 chr7:150070692 REPIN1 0.42 6.67 0.38 1.48e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs7267979 0.565 rs4815432 chr20:25556403 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.69 -10.97 -0.56 2.46e-23 Liver enzyme levels (alkaline phosphatase); CESC trans rs561341 0.739 rs9906455 chr17:30215669 G/A cg20587970 chr11:113659929 NA 0.59 7.54 0.42 7.58e-13 Hip circumference adjusted for BMI; CESC cis rs17253792 0.822 rs17253744 chr14:56161950 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.57 0.32 6.22e-8 Putamen volume; CESC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg26338869 chr17:61819248 STRADA 0.68 8.9 0.48 8.82e-17 Prudent dietary pattern; CESC cis rs6499255 1.000 rs55992518 chr16:69821407 C/T cg15192750 chr16:69999425 NA 0.46 5.64 0.33 4.46e-8 IgE levels; CESC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.26 -0.31 2.94e-7 Obesity-related traits; CESC cis rs1059312 0.545 rs12303387 chr12:129276733 C/T cg09035930 chr12:129282057 SLC15A4 -0.5 -6.38 -0.37 7.74e-10 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25042239 chr6:43021668 CUL7 0.6 6.82 0.39 6.11e-11 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg22535103 chr8:58192502 C8orf71 -1.03 -12.89 -0.62 7.67e-30 Developmental language disorder (linguistic errors); CESC cis rs6429082 0.755 rs291372 chr1:235694106 G/C cg26050004 chr1:235667680 B3GALNT2 0.66 8.67 0.47 4.37e-16 Adiposity; CESC cis rs12545109 0.571 rs1370306 chr8:57299137 C/G cg09654669 chr8:57350985 NA -0.49 -5.95 -0.34 8.29e-9 Obesity-related traits; CESC cis rs3617 0.573 rs4687680 chr3:52907372 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.3 5.08 0.3 7.26e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs3806843 1.000 rs13157397 chr5:140184442 G/A cg26395211 chr5:140044315 WDR55 -0.45 -5.71 -0.33 3.06e-8 Depressive symptoms (multi-trait analysis); CESC cis rs60733400 0.818 rs10909839 chr1:2708430 G/A cg20673091 chr1:2541236 MMEL1 0.48 7.83 0.43 1.18e-13 Multiple sclerosis; CESC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg07507251 chr3:52567010 NT5DC2 0.38 6.72 0.38 1.1e-10 Electroencephalogram traits; CESC cis rs1707322 0.662 rs11211160 chr1:46146229 T/A cg03146154 chr1:46216737 IPP 0.8 11.28 0.57 2.35e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9929218 0.911 rs4783686 chr16:68834156 C/G cg02972257 chr16:68554789 NA 0.5 5.8 0.34 1.9e-8 Colorectal cancer; CESC cis rs2625529 0.761 rs3743224 chr15:72466799 C/T cg16672083 chr15:72433130 SENP8 -0.4 -5.13 -0.3 5.65e-7 Red blood cell count; CESC cis rs11051970 0.559 rs113700251 chr12:32562271 G/A cg24626660 chr12:32551988 NA 0.36 5.19 0.3 4.24e-7 Response to tocilizumab in rheumatoid arthritis; CESC trans rs1888221 0.580 rs4460459 chr9:117817326 A/G cg11017500 chr13:111290755 CARKD -0.46 -6.19 -0.36 2.32e-9 Glucose homeostasis traits; CESC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg07677032 chr17:61819896 STRADA 0.44 5.79 0.34 2e-8 Prudent dietary pattern; CESC cis rs4808199 0.895 rs8105094 chr19:19374061 C/T cg03709012 chr19:19516395 GATAD2A 1.09 11.63 0.58 1.52e-25 Nonalcoholic fatty liver disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10605791 chr12:122242589 SETD1B;LOC338799 0.56 6.4 0.37 6.88e-10 Gut microbiome composition (summer); CESC cis rs6089584 1.000 rs6089580 chr20:60558976 G/A cg06108461 chr20:60628389 TAF4 -0.78 -11.36 -0.57 1.25e-24 Body mass index; CESC cis rs9486719 1.000 rs4262195 chr6:96929475 T/C cg18709589 chr6:96969512 KIAA0776 -0.54 -5.97 -0.34 7.42e-9 Migraine;Coronary artery disease; CESC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.42 0.32 1.32e-7 Cognitive function; CESC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg13777783 chr17:79615861 NA 0.36 6.15 0.35 2.83e-9 Eye color traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00634145 chr1:155108588 RAG1AP1 -0.42 -6.0 -0.35 6.42e-9 Gambling; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03257047 chr6:52860152 GSTA4 -0.49 -6.12 -0.35 3.27e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs12579753 0.871 rs10862364 chr12:82201280 C/T cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs61931739 0.534 rs11053072 chr12:34202399 A/C cg19457237 chr12:34500585 NA -0.38 -5.33 -0.31 2.12e-7 Morning vs. evening chronotype; CESC cis rs7772486 0.790 rs9399571 chr6:146282061 A/G cg23711669 chr6:146136114 FBXO30 -0.92 -13.15 -0.63 9.83e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs4835473 0.835 rs1450247 chr4:144629682 T/A cg25736465 chr4:144833511 NA 0.4 6.17 0.35 2.59e-9 Immature fraction of reticulocytes; CESC trans rs13098911 0.540 rs41289622 chr3:46014545 T/G cg10236987 chr1:228114221 WNT9A 0.55 6.0 0.35 6.33e-9 Celiac disease; CESC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg13395646 chr4:1353034 KIAA1530 -0.49 -6.32 -0.36 1.08e-9 Obesity-related traits; CESC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg25517755 chr10:38738941 LOC399744 -0.49 -6.35 -0.36 9.08e-10 Extrinsic epigenetic age acceleration; CESC cis rs863345 0.604 rs10908670 chr1:158502113 T/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg25019033 chr10:957182 NA -0.6 -6.19 -0.36 2.24e-9 Eosinophil percentage of granulocytes; CESC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg25072359 chr17:41440525 NA 0.47 6.21 0.36 2.04e-9 Menopause (age at onset); CESC cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg23711669 chr6:146136114 FBXO30 1.02 15.96 0.7 1.2e-40 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00042657 chr1:171753628 METTL13 -0.53 -6.23 -0.36 1.81e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22368307 chr11:75110460 SNORD15A;RPS3 -0.6 -7.14 -0.4 9.22e-12 Gut microbiome composition (summer); CESC trans rs561341 0.941 rs8066156 chr17:30361629 A/G cg20587970 chr11:113659929 NA -1.04 -13.26 -0.63 3.99e-31 Hip circumference adjusted for BMI; CESC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg19257562 chr1:2043853 PRKCZ 0.42 6.71 0.38 1.16e-10 Height; CESC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg02461776 chr11:598696 PHRF1 0.51 5.92 0.34 1.01e-8 Systemic lupus erythematosus; CESC cis rs2274273 0.564 rs3783649 chr14:55834410 G/A cg04306507 chr14:55594613 LGALS3 0.3 5.28 0.31 2.65e-7 Protein biomarker; CESC cis rs7216064 0.953 rs11871285 chr17:65840809 G/T cg12091567 chr17:66097778 LOC651250 -0.86 -8.83 -0.48 1.49e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2730245 0.593 rs842699 chr7:158663404 T/A cg15303052 chr7:158526867 ESYT2 -0.4 -5.07 -0.3 7.39e-7 Height; CESC cis rs11264213 0.786 rs72659692 chr1:36292258 A/G cg27506609 chr1:36549197 TEKT2 0.61 5.04 0.3 8.54e-7 Schizophrenia; CESC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06051576 chr16:2097632 TSC2;NTHL1 0.63 6.77 0.38 8.48e-11 Gut microbiome composition (summer); CESC cis rs9287719 0.781 rs12472807 chr2:10781605 G/A cg00105475 chr2:10696890 NA 0.36 5.18 0.3 4.37e-7 Prostate cancer; CESC cis rs6088580 0.601 rs6120668 chr20:33099793 A/G cg24642439 chr20:33292090 TP53INP2 0.51 6.62 0.38 1.99e-10 Glomerular filtration rate (creatinine); CESC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.73 -10.03 -0.52 2.8e-20 Total body bone mineral density; CESC cis rs3820928 0.934 rs60141402 chr2:227761445 A/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.72 -0.33 2.92e-8 Pulmonary function; CESC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07195126 chr1:160370843 VANGL2 -0.54 -6.02 -0.35 5.84e-9 Gut microbiome composition (summer); CESC cis rs11958404 0.932 rs72818113 chr5:157439825 G/T cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC trans rs4927850 1.000 rs10881563 chr3:195750225 A/G cg16724585 chr3:197361211 NA -0.6 -7.61 -0.42 4.83e-13 Pancreatic cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08943696 chr12:131437802 GPR133 -0.37 -6.01 -0.35 6.28e-9 Gambling; CESC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg06456125 chr7:65229604 NA -0.4 -5.27 -0.31 2.8e-7 Aortic root size; CESC cis rs9300255 0.620 rs7313483 chr12:123726834 C/T cg00376283 chr12:123451042 ABCB9 0.72 8.7 0.47 3.47e-16 Neutrophil percentage of white cells; CESC cis rs10883723 0.810 rs1409311 chr10:104282160 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.88 -0.34 1.23e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7249698 1 rs7249698 chr19:17210615 G/A cg19418318 chr19:17219073 MYO9B 0.34 5.58 0.32 6.05e-8 Breast cancer; CESC cis rs13082711 0.911 rs34878935 chr3:27466123 A/C cg02860705 chr3:27208620 NA 0.58 7.29 0.41 3.49e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs6901004 0.570 rs783084 chr6:111477887 T/C cg15721981 chr6:111408429 SLC16A10 0.53 7.0 0.4 2.04e-11 Blood metabolite levels; CESC cis rs1538970 0.962 rs2153609 chr1:45814058 A/G cg05343316 chr1:45956843 TESK2 0.72 10.15 0.53 1.14e-20 Platelet count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05839636 chr5:137878905 ETF1 -0.44 -6.2 -0.36 2.17e-9 Gambling; CESC cis rs6831352 0.918 rs2602894 chr4:100045647 A/G cg12011299 chr4:100065546 ADH4 0.59 6.68 0.38 1.41e-10 Alcohol dependence; CESC cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg25427524 chr10:38739819 LOC399744 -0.67 -9.71 -0.51 2.79e-19 Extrinsic epigenetic age acceleration; CESC cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg23711669 chr6:146136114 FBXO30 1.03 15.86 0.7 2.71e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs35955747 0.869 rs5997971 chr22:31792292 C/T cg25791279 chr22:32026902 PISD -0.45 -5.48 -0.32 9.94e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs9462846 0.919 rs6936722 chr6:42891311 A/G cg02353165 chr6:42928485 GNMT -0.42 -5.06 -0.3 7.82e-7 Blood protein levels; CESC cis rs6429082 0.818 rs453315 chr1:235680585 C/T cg26050004 chr1:235667680 B3GALNT2 0.62 7.61 0.42 4.89e-13 Adiposity; CESC cis rs8067354 0.789 rs1292068 chr17:57929319 T/C cg02344993 chr17:57696989 CLTC 0.5 6.61 0.38 2.12e-10 Hemoglobin concentration; CESC cis rs1559088 0.522 rs7254912 chr19:33554151 A/G cg17764715 chr19:33622953 WDR88 0.59 8.26 0.45 6.91e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7589342 0.745 rs933793 chr2:106511846 C/T cg16077055 chr2:106428750 NCK2 -0.37 -5.17 -0.3 4.53e-7 Addiction; CESC cis rs6500395 0.962 rs1386042 chr16:48600332 G/A cg04672837 chr16:48644449 N4BP1 0.46 5.6 0.33 5.47e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7772486 0.806 rs2253648 chr6:146199296 G/A cg05347473 chr6:146136440 FBXO30 0.51 6.75 0.38 9.2e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg26769984 chr7:1090371 C7orf50 0.65 7.23 0.41 5.05e-12 Bronchopulmonary dysplasia; CESC cis rs7116495 0.609 rs4945392 chr11:71694645 C/T cg07596299 chr11:71824057 C11orf51 -0.85 -5.48 -0.32 9.86e-8 Severe influenza A (H1N1) infection; CESC cis rs728616 0.681 rs12413174 chr10:82062404 G/A cg05935833 chr10:81318306 SFTPA2 -0.46 -5.84 -0.34 1.56e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs1005277 0.505 rs200935 chr10:38132810 T/A cg00409905 chr10:38381863 ZNF37A -0.54 -7.55 -0.42 7.25e-13 Extrinsic epigenetic age acceleration; CESC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg02807482 chr3:125708958 NA -0.4 -5.14 -0.3 5.45e-7 Blood pressure (smoking interaction); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25766537 chr1:168147996 TIPRL -0.52 -6.13 -0.35 3.19e-9 Ulcerative colitis; CESC cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.24 0.31 3.22e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.97 0.48 5.62e-17 Bipolar disorder; CESC cis rs12887734 0.546 rs66676135 chr14:104271504 G/A cg08213375 chr14:104286397 PPP1R13B 0.42 7.16 0.4 7.84e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg24818145 chr4:99064322 C4orf37 0.4 5.14 0.3 5.46e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.24 0.31 3.22e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg16145915 chr7:1198662 ZFAND2A -0.48 -6.62 -0.38 1.97e-10 Longevity;Endometriosis; CESC cis rs17407555 0.821 rs73215081 chr4:10137326 C/G cg11266682 chr4:10021025 SLC2A9 -0.48 -5.29 -0.31 2.58e-7 Schizophrenia (age at onset); CESC cis rs7927592 0.956 rs2155730 chr11:68329474 T/C cg20283391 chr11:68216788 NA -0.49 -5.87 -0.34 1.29e-8 Total body bone mineral density; CESC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg20243544 chr17:37824526 PNMT -0.49 -6.24 -0.36 1.75e-9 Glomerular filtration rate (creatinine); CESC cis rs453301 0.571 rs2929453 chr8:9084341 A/G cg15556689 chr8:8085844 FLJ10661 -0.52 -6.61 -0.38 2.16e-10 Joint mobility (Beighton score); CESC trans rs8073060 0.559 rs72829925 chr17:34049778 C/A cg19694781 chr19:47549865 TMEM160 0.71 6.55 0.37 3.03e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs2730245 1.000 rs2657365 chr7:158722753 A/T cg15303052 chr7:158526867 ESYT2 0.43 5.11 0.3 6.17e-7 Height; CESC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg04518342 chr5:131593106 PDLIM4 -0.39 -5.62 -0.33 4.83e-8 Breast cancer; CESC cis rs10979 0.597 rs9484776 chr6:143906325 T/C cg25407410 chr6:143891975 LOC285740 -0.5 -6.68 -0.38 1.42e-10 Hypospadias; CESC cis rs7726839 0.794 rs10474792 chr5:600058 G/A cg16447950 chr5:562315 NA -0.49 -5.77 -0.33 2.18e-8 Obesity-related traits; CESC cis rs17125944 0.505 rs17125746 chr14:53236079 C/T cg00686598 chr14:53173677 PSMC6 1.32 11.44 0.58 6.67e-25 Alzheimer's disease (late onset); CESC cis rs10242455 0.702 rs10251282 chr7:98990236 T/C cg25640893 chr7:99214727 ZNF498 1.04 6.31 0.36 1.15e-9 Blood metabolite levels; CESC cis rs7623687 0.786 rs73088161 chr3:49465162 C/T cg19401529 chr3:49056140 DALRD3 0.67 5.13 0.3 5.69e-7 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CESC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.9e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11252926 0.966 rs61831030 chr10:578869 C/T cg08603382 chr10:743973 NA -0.6 -7.33 -0.41 2.74e-12 Psychosis in Alzheimer's disease; CESC cis rs910316 0.763 rs175435 chr14:75612025 A/G cg08847533 chr14:75593920 NEK9 0.89 15.16 0.68 8.13e-38 Height; CESC cis rs7617773 0.925 rs34513961 chr3:48173653 T/C cg11946769 chr3:48343235 NME6 0.91 11.8 0.59 4.25e-26 Coronary artery disease; CESC cis rs8072100 0.782 rs28507314 chr17:45551402 C/T cg08085267 chr17:45401833 C17orf57 -0.58 -7.7 -0.43 2.77e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7216064 1.000 rs12451721 chr17:65939075 G/A cg07042672 chr17:66097459 LOC651250 -0.52 -5.35 -0.31 1.9e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg23758822 chr17:41437982 NA 1.03 15.66 0.69 1.37e-39 Menopause (age at onset); CESC cis rs6582630 0.519 rs12819814 chr12:38332568 G/C cg26384229 chr12:38710491 ALG10B 0.69 10.38 0.54 2.16e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs748404 0.660 rs2439846 chr15:43740970 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.61 0.42 4.92e-13 Lung cancer; CESC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg06221963 chr1:154839813 KCNN3 -0.66 -11.17 -0.57 5.33e-24 Prostate cancer; CESC cis rs7107174 0.681 rs10751288 chr11:78072658 A/T cg02023728 chr11:77925099 USP35 0.47 6.23 0.36 1.82e-9 Testicular germ cell tumor; CESC cis rs9847710 0.566 rs2564951 chr3:53060449 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.34 -5.31 -0.31 2.29e-7 Ulcerative colitis; CESC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg05368731 chr17:41323189 NBR1 0.78 11.14 0.56 6.78e-24 Menopause (age at onset); CESC cis rs899997 1.000 rs11629824 chr15:79005524 T/G cg04896959 chr15:78267971 NA 0.42 6.35 0.36 9.31e-10 Coronary artery disease or large artery stroke; CESC cis rs7917772 0.503 rs7087665 chr10:104282418 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.59 0.42 5.46e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25117505 chr11:66313529 ZDHHC24;ACTN3 -0.54 -6.85 -0.39 5.2e-11 Ulcerative colitis; CESC cis rs7923609 0.846 rs9787438 chr10:65038030 G/C cg01631684 chr10:65280961 REEP3 -0.44 -5.4 -0.31 1.51e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg21782813 chr7:2030301 MAD1L1 0.39 5.75 0.33 2.4e-8 Schizophrenia; CESC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg26939375 chr7:64535504 NA -0.69 -9.98 -0.52 4.16e-20 Calcium levels; CESC cis rs61008539 0.821 rs10950789 chr7:897492 A/G cg00934597 chr7:893267 UNC84A -0.55 -7.42 -0.41 1.6e-12 Perceived unattractiveness to mosquitoes; CESC cis rs2073300 1.000 rs6132625 chr20:23444671 C/T cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs72945132 0.714 rs66542029 chr11:70196302 A/T cg00319359 chr11:70116639 PPFIA1 0.72 6.79 0.38 7.38e-11 Coronary artery disease; CESC cis rs6502050 0.871 rs8066970 chr17:80076051 T/C cg23985595 chr17:80112537 CCDC57 0.41 6.4 0.37 6.88e-10 Life satisfaction; CESC cis rs28374715 0.662 rs72737792 chr15:41515589 G/C cg18705301 chr15:41695430 NDUFAF1 -0.8 -10.11 -0.53 1.59e-20 Ulcerative colitis; CESC cis rs61935443 0.666 rs11107781 chr12:95301086 T/A cg21533806 chr12:95267307 NA 0.48 5.24 0.31 3.27e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20756934 chr12:56510353 RPL41 0.64 6.99 0.39 2.19e-11 Gut microbiome composition (summer); CESC cis rs12477438 0.765 rs7591992 chr2:99668954 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs8067545 0.611 rs8066143 chr17:20048355 A/C cg13482628 chr17:19912719 NA 0.39 5.12 0.3 5.8e-7 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10582045 chr15:43477796 CCNDBP1 -0.47 -6.24 -0.36 1.71e-9 Ulcerative colitis; CESC cis rs7772486 0.875 rs9376975 chr6:146355581 T/G cg05347473 chr6:146136440 FBXO30 0.5 6.51 0.37 3.72e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4253772 0.591 rs11703435 chr22:46685563 C/T cg10541313 chr22:46663664 TTC38 0.72 5.15 0.3 5.01e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7927771 0.965 rs12787112 chr11:47687147 A/G cg20307385 chr11:47447363 PSMC3 -0.49 -5.99 -0.35 6.84e-9 Subjective well-being; CESC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg26335602 chr6:28129616 ZNF389 0.54 7.3 0.41 3.37e-12 Parkinson's disease; CESC cis rs7116495 1.000 rs7116495 chr11:71762085 C/T cg26138937 chr11:71823887 C11orf51 -0.81 -6.46 -0.37 4.87e-10 Severe influenza A (H1N1) infection; CESC cis rs62064224 0.902 rs17732573 chr17:30627664 C/T cg18200150 chr17:30822561 MYO1D -0.51 -7.42 -0.41 1.62e-12 Schizophrenia; CESC cis rs2011503 0.941 rs72999063 chr19:19380596 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.51 5.18 0.3 4.38e-7 Bipolar disorder; CESC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.94 9.15 0.49 1.57e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs116095464 0.558 rs10067021 chr5:221490 C/T cg22496380 chr5:211416 CCDC127 -0.72 -8.57 -0.47 8.59e-16 Breast cancer; CESC cis rs644799 0.965 rs566877 chr11:95528045 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs67311347 1.000 rs1123019 chr3:40488280 C/T cg09455208 chr3:40491958 NA 0.49 8.04 0.44 2.91e-14 Renal cell carcinoma; CESC cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs12477438 0.539 rs12999417 chr2:99865548 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.81 -12.82 -0.62 1.36e-29 Chronic sinus infection; CESC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg23283495 chr1:209979779 IRF6 0.53 6.34 0.36 9.65e-10 Cleft lip with or without cleft palate; CESC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg18225595 chr11:63971243 STIP1 0.52 5.19 0.3 4.19e-7 Mean platelet volume; CESC cis rs9287719 1.000 rs9287719 chr2:10710730 C/T cg00105475 chr2:10696890 NA 0.39 5.71 0.33 3.1e-8 Prostate cancer; CESC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg00129232 chr17:37814104 STARD3 0.59 7.88 0.44 8.71e-14 Glomerular filtration rate (creatinine); CESC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg04166393 chr7:2884313 GNA12 0.6 7.73 0.43 2.27e-13 Height; CESC cis rs9399401 0.601 rs262120 chr6:142842360 C/A cg03128060 chr6:142623767 GPR126 0.33 5.42 0.32 1.35e-7 Chronic obstructive pulmonary disease; CESC cis rs7937682 0.889 rs497111 chr11:111499512 G/A cg09085632 chr11:111637200 PPP2R1B -0.99 -15.77 -0.7 5.94e-40 Primary sclerosing cholangitis; CESC cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg06212747 chr3:49208901 KLHDC8B -0.7 -9.54 -0.51 9.56e-19 Parkinson's disease; CESC trans rs11039798 0.764 rs12277213 chr11:48782176 G/A cg15704280 chr7:45808275 SEPT13 0.7 6.35 0.36 9.09e-10 Axial length; CESC cis rs28374715 0.528 rs7181982 chr15:41623020 C/G cg18705301 chr15:41695430 NDUFAF1 -1.05 -15.46 -0.69 6.98e-39 Ulcerative colitis; CESC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs10504229 0.906 rs2270609 chr8:58194684 G/A cg02725872 chr8:58115012 NA -0.35 -5.17 -0.3 4.69e-7 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03773196 chr1:219786527 NA -0.39 -6.0 -0.35 6.63e-9 Gut microbiota (bacterial taxa); CESC cis rs1050631 0.960 rs1789512 chr18:33694542 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 -0.45 -5.81 -0.34 1.82e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs4909189 1.000 rs12698214 chr7:158136204 T/G cg06219351 chr7:158114137 PTPRN2 -0.58 -7.18 -0.4 6.86e-12 Response to amphetamines; CESC cis rs7264396 0.635 rs6121073 chr20:34457513 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -11.17 -0.57 5.37e-24 Total cholesterol levels; CESC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg00908189 chr16:619842 PIGQ 0.66 9.4 0.5 2.63e-18 Height; CESC trans rs61931739 0.500 rs7298322 chr12:34445489 A/T cg26384229 chr12:38710491 ALG10B 0.54 7.5 0.42 9.79e-13 Morning vs. evening chronotype; CESC cis rs9300255 0.602 rs1727296 chr12:123647725 G/C cg19016782 chr12:123741754 C12orf65 -0.4 -5.77 -0.33 2.27e-8 Neutrophil percentage of white cells; CESC cis rs3733585 0.699 rs13328050 chr4:9951120 G/T cg11266682 chr4:10021025 SLC2A9 -0.57 -10.45 -0.54 1.27e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7116495 0.609 rs2852365 chr11:71715218 T/C cg18441811 chr11:71824068 C11orf51 -0.79 -5.33 -0.31 2.06e-7 Severe influenza A (H1N1) infection; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21395782 chr19:19626814 NDUFA13;TSSK6 0.47 6.32 0.36 1.11e-9 Gut microbiota (bacterial taxa); CESC cis rs67311347 1.000 rs73080126 chr3:40509153 A/G cg24209194 chr3:40518798 ZNF619 0.5 6.09 0.35 4.06e-9 Renal cell carcinoma; CESC cis rs7267979 0.932 rs424487 chr20:25468131 C/G cg08601574 chr20:25228251 PYGB 0.39 5.61 0.33 5.2100000000000003e-08 Liver enzyme levels (alkaline phosphatase); CESC trans rs11098499 0.954 rs71629403 chr4:120372567 C/T cg25214090 chr10:38739885 LOC399744 0.71 9.8 0.52 1.46e-19 Corneal astigmatism; CESC cis rs3087591 0.960 rs2269855 chr17:29482878 G/A cg24425628 chr17:29625626 OMG;NF1 0.41 5.13 0.3 5.71e-7 Hip circumference; CESC cis rs5769765 0.862 rs9616774 chr22:50290599 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.14 -0.3 5.24e-7 Schizophrenia; CESC cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg10523679 chr1:76189770 ACADM 0.72 8.33 0.46 4.38e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs228437 0.609 rs7749956 chr6:134961973 C/T cg24504307 chr6:134963096 NA -0.38 -5.13 -0.3 5.5e-7 Melanoma; CESC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg00129232 chr17:37814104 STARD3 0.51 6.35 0.36 9.57e-10 Glomerular filtration rate (creatinine); CESC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg02951883 chr7:2050386 MAD1L1 -0.49 -6.25 -0.36 1.66e-9 Schizophrenia, schizoaffective disorder or bipolar disorder; CESC cis rs1008375 0.806 rs13139898 chr4:17706928 T/G cg02297831 chr4:17616191 MED28 -0.54 -6.44 -0.37 5.54e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7412746 0.658 rs12067685 chr1:150952917 T/C cg04414720 chr1:150670196 GOLPH3L 0.49 6.47 0.37 4.65e-10 Melanoma; CESC cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.89 12.15 0.6 2.69e-27 Multiple sclerosis; CESC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11785400 0.793 rs11543967 chr8:143739435 A/G cg24634471 chr8:143751801 JRK -0.46 -5.68 -0.33 3.49e-8 Schizophrenia; CESC cis rs11122272 0.735 rs2572254 chr1:231512593 T/C cg06096015 chr1:231504339 EGLN1 0.42 6.11 0.35 3.53e-9 Hemoglobin concentration; CESC cis rs1707322 1.000 rs6693336 chr1:46354595 C/T cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg10862848 chr6:42927986 GNMT -0.3 -7.57 -0.42 6.2e-13 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2629540 0.889 rs7476729 chr10:126428174 C/G cg08799069 chr10:126477246 METTL10 -0.67 -8.85 -0.48 1.26e-16 Cocaine dependence; CESC cis rs1198430 0.925 rs2811975 chr1:23801081 A/T cg22040403 chr1:23858016 E2F2 0.71 5.27 0.31 2.83e-7 Total cholesterol levels; CESC cis rs262147 1.000 rs262147 chr7:158745142 A/G cg24397884 chr7:158709396 WDR60 0.7 5.52 0.32 8.17e-8 Hippocampal volume; CESC cis rs9403521 0.947 rs7741424 chr6:143981662 G/A cg21026257 chr6:143998961 PHACTR2 0.46 5.03 0.3 8.88e-7 Obesity-related traits; CESC cis rs9858542 0.953 rs11715915 chr3:49455330 A/G cg03060546 chr3:49711283 APEH 0.57 6.19 0.36 2.33e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs896543 0.702 rs6711222 chr2:237494444 C/T cg25295825 chr2:237489920 CXCR7 0.71 9.11 0.49 2.11e-17 Alcohol dependence (age at onset); CESC cis rs897984 0.762 rs7206511 chr16:30950352 G/A cg00531865 chr16:30841666 NA 0.51 7.01 0.4 1.99e-11 Dementia with Lewy bodies; CESC cis rs7100689 0.784 rs7089058 chr10:82071263 T/C cg00277334 chr10:82204260 NA -0.57 -7.29 -0.41 3.53e-12 Post bronchodilator FEV1; CESC cis rs8141529 0.753 rs5752813 chr22:29226570 T/G cg02153584 chr22:29168773 CCDC117 0.63 9.06 0.49 3.01e-17 Lymphocyte counts; CESC cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 3.05e-8 Mean platelet volume; CESC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg11366901 chr6:160182831 ACAT2 0.83 10.41 0.54 1.65e-21 Age-related macular degeneration (geographic atrophy); CESC cis rs1580019 1.000 rs1580019 chr7:32493169 A/T cg06627557 chr7:32535165 LSM5;AVL9 -0.78 -10.76 -0.55 1.23e-22 Cognitive ability; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05566397 chr7:104654900 MLL5;LOC100216545 -0.45 -6.28 -0.36 1.37e-9 Gut microbiota (bacterial taxa); CESC cis rs62244186 0.535 rs59726036 chr3:44850074 G/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.49 6.46 0.37 5.08e-10 Depressive symptoms; CESC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg26314531 chr2:26401878 FAM59B -0.82 -9.03 -0.48 3.69e-17 Gut microbiome composition (summer); CESC cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -10.25 -0.53 5.55e-21 Chronic sinus infection; CESC cis rs734999 0.545 rs10752748 chr1:2544640 G/A cg20673091 chr1:2541236 MMEL1 0.45 7.42 0.41 1.63e-12 Ulcerative colitis; CESC cis rs7084402 0.967 rs7897298 chr10:60274606 T/C cg07615347 chr10:60278583 BICC1 -0.57 -8.96 -0.48 6.01e-17 Refractive error; CESC cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg23711669 chr6:146136114 FBXO30 0.98 14.74 0.67 2.54e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs10883723 0.810 rs6584507 chr10:104254623 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs8077889 0.956 rs58242860 chr17:41847300 T/C cg26893861 chr17:41843967 DUSP3 0.74 8.79 0.48 1.87e-16 Triglycerides; CESC cis rs7647973 0.961 rs6778080 chr3:49317338 C/T cg06212747 chr3:49208901 KLHDC8B -0.5 -6.71 -0.38 1.19e-10 Menarche (age at onset); CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg22907277 chr7:1156413 C7orf50 0.46 6.65 0.38 1.65e-10 Longevity;Endometriosis; CESC cis rs4906332 1.000 rs12896919 chr14:103956713 T/C cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.49e-10 Coronary artery disease; CESC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg15369054 chr17:80825471 TBCD 0.57 8.08 0.44 2.26e-14 Breast cancer; CESC cis rs4523957 0.757 rs216199 chr17:2200871 C/T cg16513277 chr17:2031491 SMG6 0.57 7.71 0.43 2.56e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4561483 0.831 rs33648 chr16:11979622 G/A cg08843971 chr16:11963173 GSPT1 -0.4 -5.47 -0.32 1.03e-7 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07003673 chr12:123459818 ABCB9;OGFOD2 -0.63 -6.94 -0.39 2.95e-11 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs10043002 chr5:226753 G/A cg10591111 chr5:226296 SDHA -0.55 -6.81 -0.39 6.5e-11 Breast cancer; CESC trans rs2727020 0.729 rs2204366 chr11:49349367 A/C cg03929089 chr4:120376271 NA 0.79 12.06 0.6 5.6e-27 Coronary artery disease; CESC cis rs15676 0.783 rs2977996 chr9:131582625 C/T cg00228799 chr9:131580591 ENDOG 0.56 7.2 0.4 6.12e-12 Blood metabolite levels; CESC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg18876405 chr7:65276391 NA 0.51 5.96 0.34 7.82e-9 Aortic root size; CESC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg24578937 chr1:2090814 PRKCZ -0.34 -5.87 -0.34 1.31e-8 Height; CESC cis rs61612642 0.523 rs59004693 chr6:42157392 G/A cg10382835 chr6:42185730 MRPS10 0.67 5.98 0.34 7.16e-9 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs2204008 0.837 rs11612397 chr12:38357455 T/C cg26384229 chr12:38710491 ALG10B 0.73 10.95 0.56 2.81e-23 Bladder cancer; CESC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.68 -0.33 3.51e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg00484396 chr16:3507460 NAT15 -0.41 -6.59 -0.38 2.39e-10 Tuberculosis; CESC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.02 11.26 0.57 2.8e-24 Platelet count; CESC cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg08847533 chr14:75593920 NEK9 0.72 11.04 0.56 1.41e-23 Coronary artery disease; CESC cis rs9303401 0.625 rs66508449 chr17:56691034 T/C cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.55 0.61 1.16e-28 Cognitive test performance; CESC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg07308232 chr7:1071921 C7orf50 -0.43 -5.93 -0.34 9.32e-9 Longevity;Endometriosis; CESC cis rs1050631 0.592 rs1785903 chr18:33711642 G/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.57 7.99 0.44 4.09e-14 Esophageal squamous cell cancer (length of survival); CESC cis rs3741798 1.000 rs61922025 chr12:12486263 G/A cg08615371 chr12:12503544 MANSC1 0.87 6.35 0.36 9.19e-10 Cerebrospinal fluid biomarker levels; CESC cis rs2404602 0.647 rs12903586 chr15:77168240 G/A cg23625390 chr15:77176239 SCAPER -0.45 -6.34 -0.36 1.01e-9 Blood metabolite levels; CESC cis rs8070624 0.543 rs11078409 chr17:17876296 C/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.53 6.69 0.38 1.3100000000000001e-10 Total body bone mineral density; CESC cis rs4604732 0.631 rs12031721 chr1:247623773 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.49 6.04 0.35 5.16e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14018420 chr1:21766356 NBPF3 -0.42 -6.04 -0.35 5.1e-9 Fibrinogen levels; CESC cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12618769 0.597 rs3754884 chr2:99125376 C/T cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs116095464 0.558 rs113796397 chr5:246503 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.22 0.31 3.58e-7 Breast cancer; CESC cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg03467027 chr4:99064603 C4orf37 0.44 5.45 0.32 1.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg05283184 chr6:79620031 NA -0.43 -6.79 -0.38 7.42e-11 Intelligence (multi-trait analysis); CESC cis rs12791968 0.765 rs12790121 chr11:45001089 G/A cg11846598 chr11:44996168 LOC221122 -0.48 -5.81 -0.34 1.78e-8 Inhibitory control; CESC cis rs5750830 0.620 rs1007337 chr22:39781585 C/T cg11247378 chr22:39784982 NA -0.55 -8.48 -0.46 1.6e-15 Intelligence (multi-trait analysis); CESC cis rs12477438 0.715 rs7586608 chr2:99558017 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.85 -0.48 1.25e-16 Chronic sinus infection; CESC cis rs10871290 0.801 rs3851726 chr16:74471644 G/C cg01733217 chr16:74700730 RFWD3 -0.65 -8.7 -0.47 3.57e-16 Breast cancer; CESC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg10691866 chr7:65817282 TPST1 -0.36 -6.13 -0.35 3.09e-9 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21956150 chr19:1438388 RPS15 0.47 6.75 0.38 9.55e-11 Gut microbiota (bacterial taxa); CESC cis rs4975709 0.609 rs2232373 chr5:1882280 C/G cg15595755 chr5:1867978 NA 0.48 7.35 0.41 2.4e-12 Cardiovascular disease risk factors; CESC cis rs11098499 0.866 rs7677068 chr4:120291704 C/T cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Depression; CESC cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.12 0.3 5.85e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72945132 0.882 rs55738915 chr11:70190019 C/T cg14191688 chr11:70257035 CTTN 0.44 5.43 0.32 1.31e-7 Coronary artery disease; CESC cis rs754466 0.606 rs10824581 chr10:79599501 A/G cg17075019 chr10:79541650 NA -0.87 -13.73 -0.64 8.77e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3026101 0.671 rs3026129 chr17:5295371 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs7100689 0.622 rs10749595 chr10:82172975 C/T cg00277334 chr10:82204260 NA -0.57 -7.07 -0.4 1.38e-11 Post bronchodilator FEV1; CESC cis rs3733585 0.699 rs7677710 chr4:9969517 T/G cg11266682 chr4:10021025 SLC2A9 -0.57 -10.92 -0.56 3.5e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs79349575 0.870 rs12941262 chr17:46967037 T/A cg16584676 chr17:46985605 UBE2Z 0.55 6.62 0.38 2.03e-10 Type 2 diabetes; CESC cis rs75477785 0.590 rs76089065 chr1:210298225 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.77 5.34 0.31 2.03e-7 Cleft lip with or without cleft palate; CESC cis rs634534 0.622 rs593525 chr11:65727799 T/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.39 5.21 0.3 3.85e-7 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs3820068 0.705 rs57238793 chr1:15890029 A/G cg17385448 chr1:15911702 AGMAT 0.41 6.05 0.35 4.91e-9 Systolic blood pressure; CESC cis rs7923609 0.936 rs10740125 chr10:65209609 T/C cg01631684 chr10:65280961 REEP3 -0.43 -5.39 -0.31 1.55e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs12451471 0.637 rs7567 chr17:78093549 G/T cg06718696 chr17:78121285 EIF4A3 0.86 10.52 0.54 7.61e-22 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg18305652 chr10:134549665 INPP5A 0.47 6.77 0.38 8.43e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg27014927 chr22:45403808 PHF21B -0.36 -6.15 -0.35 2.89e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1018836 0.851 rs12548741 chr8:91628878 G/A cg16814680 chr8:91681699 NA -0.72 -10.07 -0.53 2.16e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9467773 1.000 rs9295695 chr6:26528250 C/T cg20266910 chr6:26577678 NA -0.33 -5.46 -0.32 1.08e-7 Intelligence (multi-trait analysis); CESC cis rs11997175 0.624 rs7001604 chr8:33680979 T/C ch.8.33884649F chr8:33765107 NA 0.57 7.38 0.41 2.01e-12 Body mass index; CESC cis rs9623117 0.915 rs9611261 chr22:40466872 A/G cg05033341 chr22:40419857 FAM83F -0.43 -5.23 -0.31 3.41e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs3008870 0.755 rs2815381 chr1:67514591 G/A cg02640540 chr1:67518911 SLC35D1 0.71 9.15 0.49 1.54e-17 Lymphocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23177889 chr7:116502779 CAPZA2 0.52 6.33 0.36 1.07e-9 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg00166722 chr3:10149974 C3orf24 0.44 5.5 0.32 9.07e-8 Alzheimer's disease; CESC cis rs892961 0.899 rs72896162 chr17:75412521 A/G cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg14159672 chr1:205819179 PM20D1 0.93 16.31 0.71 6.74e-42 Menarche (age at onset); CESC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.44 6.24 0.36 1.71e-9 Menopause (age at onset); CESC trans rs561341 0.941 rs8081016 chr17:30331751 A/G cg27661571 chr11:113659931 NA -0.82 -7.6 -0.42 5.24e-13 Hip circumference adjusted for BMI; CESC cis rs2838344 0.776 rs2298561 chr21:45085234 A/G cg21573476 chr21:45109991 RRP1B -0.6 -8.91 -0.48 8.59e-17 Coronary artery disease; CESC cis rs1348850 0.874 rs1348848 chr2:178358233 A/C cg22681709 chr2:178499509 PDE11A 0.42 6.15 0.35 2.9e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6570726 0.935 rs414222 chr6:145850482 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.96e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs76917914 0.780 rs6478556 chr9:100842005 A/G cg03040243 chr9:100819229 NANS -0.48 -5.36 -0.31 1.77e-7 Immature fraction of reticulocytes; CESC cis rs73195822 0.614 rs73194057 chr12:111216913 T/C cg12870014 chr12:110450643 ANKRD13A 0.7 7.31 0.41 3.17e-12 Itch intensity from mosquito bite; CESC cis rs2730245 0.527 rs62475645 chr7:158656825 G/A cg24397884 chr7:158709396 WDR60 0.83 8.47 0.46 1.71e-15 Height; CESC trans rs11098499 0.754 rs10212775 chr4:120239244 G/C cg25214090 chr10:38739885 LOC399744 0.61 8.51 0.46 1.33e-15 Corneal astigmatism; CESC cis rs9399137 0.507 rs10484496 chr6:135299682 T/C cg22676075 chr6:135203613 NA 0.54 7.06 0.4 1.46e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs897984 0.760 rs11076 chr16:30995528 A/G cg00531865 chr16:30841666 NA 0.52 7.12 0.4 1.01e-11 Dementia with Lewy bodies; CESC cis rs506597 0.920 rs221796 chr7:100284913 C/G cg10426581 chr7:100472382 SRRT -0.7 -5.39 -0.31 1.52e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg03709012 chr19:19516395 GATAD2A 1.01 15.75 0.7 6.47e-40 Tonsillectomy; CESC cis rs9300255 0.569 rs1790115 chr12:123620270 C/G cg19016782 chr12:123741754 C12orf65 -0.38 -5.15 -0.3 5.16e-7 Neutrophil percentage of white cells; CESC cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg03467027 chr4:99064603 C4orf37 0.43 5.21 0.3 3.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7605827 0.930 rs12692272 chr2:15680801 C/T cg19274914 chr2:15703543 NA 0.36 6.38 0.36 8.01e-10 Educational attainment (years of education); CESC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.46 5.11 0.3 6.16e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg23161317 chr6:28129485 ZNF389 -0.45 -5.85 -0.34 1.44e-8 Depression; CESC cis rs9291683 0.527 rs11727087 chr4:10096020 A/G cg00071950 chr4:10020882 SLC2A9 0.66 10.9 0.56 4.19e-23 Bone mineral density; CESC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg22823121 chr1:150693482 HORMAD1 0.36 5.12 0.3 5.88e-7 Tonsillectomy; CESC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.4 5.97 0.34 7.44e-9 Total body bone mineral density; CESC cis rs1878047 0.729 rs28536511 chr19:51773511 C/A cg14884932 chr19:51774451 NA -0.37 -5.16 -0.3 4.87e-7 Body mass index; CESC cis rs155076 0.625 rs4769159 chr13:21881978 A/C cg06138931 chr13:21896616 NA 0.51 5.27 0.31 2.8e-7 White matter hyperintensity burden; CESC cis rs113835537 0.877 rs2229456 chr11:66328741 A/C cg24851651 chr11:66362959 CCS 0.52 5.1 0.3 6.51e-7 Airway imaging phenotypes; CESC cis rs72634258 0.842 rs4325151 chr1:8168917 T/A cg00042356 chr1:8021962 PARK7 -0.52 -5.62 -0.33 4.76e-8 Inflammatory bowel disease; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg09234025 chr7:6145309 USP42 -0.46 -6.09 -0.35 3.85e-9 Recombination measurement; CESC cis rs12971120 1.000 rs2278161 chr18:72176083 T/C cg26446133 chr18:72167187 CNDP2 -0.75 -9.64 -0.51 4.94e-19 Refractive error; CESC cis rs919433 0.889 rs787998 chr2:198216092 A/G cg20885578 chr2:198174922 NA 0.4 5.49 0.32 9.48e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Depression; CESC cis rs9612 0.948 rs12609056 chr19:44258702 G/T cg08581076 chr19:44259116 C19orf61 0.62 7.11 0.4 1.08e-11 Exhaled nitric oxide output; CESC cis rs943466 0.513 rs943467 chr6:33731811 A/T cg25922239 chr6:33757077 LEMD2 0.4 5.49 0.32 9.41e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; CESC cis rs921968 0.528 rs13382651 chr2:219628191 A/G cg02176678 chr2:219576539 TTLL4 -0.45 -7.81 -0.43 1.37e-13 Mean corpuscular hemoglobin concentration; CESC cis rs7520050 0.966 rs4545281 chr1:46360054 C/T cg03146154 chr1:46216737 IPP -0.44 -5.74 -0.33 2.53e-8 Red blood cell count;Reticulocyte count; CESC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17492891 chr22:41843204 TOB2 0.48 6.26 0.36 1.52e-9 Systemic lupus erythematosus; CESC cis rs936229 0.511 rs12591513 chr15:75102714 G/A cg14664628 chr15:75095509 CSK -0.71 -9.75 -0.51 2.13e-19 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs3092073 0.624 rs3848714 chr20:44547176 T/C cg27529037 chr20:44575021 PCIF1 0.64 9.72 0.51 2.61e-19 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.26 0.31 3e-7 Menopause (age at onset); CESC cis rs8005677 1.000 rs8006409 chr14:23396511 A/G cg01529538 chr14:23388837 RBM23 0.5 6.82 0.39 6.24e-11 Cognitive ability (multi-trait analysis); CESC cis rs7945705 0.967 rs10840148 chr11:8923528 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.53 8.36 0.46 3.52e-15 Hemoglobin concentration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00340921 chr19:7600526 PNPLA6 -0.46 -6.21 -0.36 2.08e-9 Fibrinogen levels; CESC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg22143856 chr6:28129313 ZNF389 0.47 5.63 0.33 4.54e-8 Parkinson's disease; CESC cis rs9362426 1.000 rs414013 chr6:88085866 T/G cg08069147 chr6:88032118 GJB7;C6orf162 0.47 5.93 0.34 9.21e-9 Depressive episodes in bipolar disorder; CESC cis rs2288073 0.801 rs10175668 chr2:24367275 G/A cg20701182 chr2:24300061 SF3B14 0.48 6.03 0.35 5.34e-9 Venous thromboembolism (SNP x SNP interaction); CESC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg08736216 chr1:53307985 ZYG11A 0.4 6.45 0.37 5.35e-10 Monocyte count; CESC cis rs1348850 0.837 rs12619074 chr2:178472336 G/A cg22681709 chr2:178499509 PDE11A -0.42 -6.39 -0.37 7.51e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2180341 0.960 rs7773484 chr6:127670779 T/C cg27446573 chr6:127587934 RNF146 1.06 15.51 0.69 4.62e-39 Breast cancer; CESC cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.13 0.3 5.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs738322 0.967 rs6001038 chr22:38570585 A/G cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC cis rs11871801 0.517 rs684214 chr17:40696915 C/T cg14558262 chr17:40713999 COASY 0.46 5.11 0.3 6.03e-7 Crohn's disease; CESC cis rs4129767 0.647 rs1976703 chr17:76401328 C/T cg05887092 chr17:76393375 PGS1 0.7 11.77 0.59 5.13e-26 HDL cholesterol; CESC cis rs1707322 1.000 rs10789479 chr1:46352500 T/C cg06784218 chr1:46089804 CCDC17 0.35 5.87 0.34 1.33e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6028335 0.674 rs68173814 chr20:37621180 A/G cg16355469 chr20:37678765 NA 0.51 5.05 0.3 8.1e-7 Alcohol and nicotine co-dependence; CESC cis rs9811920 0.609 rs4479633 chr3:99654510 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.64 -10.11 -0.53 1.53e-20 Axial length; CESC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg00149659 chr3:10157352 C3orf10 0.73 8.97 0.48 5.62e-17 Alzheimer's disease; CESC cis rs637571 0.615 rs10160792 chr11:65667149 C/G cg04055107 chr11:65626734 MUS81;CFL1 0.56 6.75 0.38 9.51e-11 Eosinophil percentage of white cells; CESC cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -6.78 -0.38 7.63e-11 Hemoglobin concentration; CESC trans rs9929218 0.906 rs4783571 chr16:68806778 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -8.03 -0.44 3.1e-14 Colorectal cancer; CESC cis rs9457247 0.588 rs35171809 chr6:167432766 A/G cg07741184 chr6:167504864 NA 0.34 6.08 0.35 4.18e-9 Crohn's disease; CESC cis rs916888 0.773 rs199535 chr17:44822662 A/G cg01570182 chr17:44337453 NA 0.88 10.36 0.54 2.51e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6459788 0.657 rs887627 chr7:157237391 G/A cg06271696 chr7:157225062 NA -0.38 -5.15 -0.3 4.97e-7 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs9660992 0.547 rs748012 chr1:205216573 C/T cg00857998 chr1:205179979 DSTYK 0.54 6.51 0.37 3.83e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs7586879 0.658 rs7563204 chr2:25125075 T/G cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.02e-11 Body mass index; CESC cis rs9814567 0.752 rs6764764 chr3:134331167 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 5.22 0.31 3.66e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7219021 0.961 rs7209108 chr17:46863898 C/T cg16584676 chr17:46985605 UBE2Z -0.69 -7.36 -0.41 2.37e-12 Schizophrenia or bipolar disorder; CESC cis rs17253792 0.915 rs75862063 chr14:56177769 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.74 5.1 0.3 6.53e-7 Putamen volume; CESC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg21770322 chr7:97807741 LMTK2 0.54 8.13 0.45 1.67e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs796364 1.000 rs769949 chr2:200729558 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.89 8.76 0.47 2.4e-16 Schizophrenia; CESC cis rs4409675 0.576 rs10751724 chr1:28215631 C/T cg23691781 chr1:28212827 C1orf38 0.29 5.67 0.33 3.72e-8 Corneal astigmatism; CESC cis rs2439831 0.850 rs16963953 chr15:44081719 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.87 0.39 4.52e-11 Lung cancer in ever smokers; CESC cis rs7208859 0.623 rs7503542 chr17:29073830 A/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs116095464 0.510 rs7714944 chr5:231765 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.36 0.31 1.84e-7 Breast cancer; CESC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg19163074 chr7:65112434 INTS4L2 0.41 5.27 0.31 2.89e-7 Aortic root size; CESC trans rs4129059 0.850 rs17023117 chr1:214680818 T/C cg08821431 chr12:34491090 NA 0.59 6.63 0.38 1.91e-10 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs11673344 0.528 rs579452 chr19:37410838 C/T cg27390819 chr19:37464633 NA -0.34 -5.12 -0.3 5.92e-7 Obesity-related traits; CESC cis rs1509123 0.609 rs78980938 chr17:6703825 T/C cg12642237 chr17:6703447 TEKT1 -0.62 -5.08 -0.3 7.26e-7 Blood metabolite levels; CESC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.82 11.95 0.59 1.25e-26 Alzheimer's disease; CESC cis rs5167 0.525 rs11083752 chr19:45454363 G/A cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.23e-14 Blood protein levels; CESC cis rs10870270 0.956 rs10870281 chr10:133762642 G/A cg26149184 chr10:133730230 NA 0.37 5.09 0.3 6.69e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs8073060 0.660 rs34184070 chr17:34003810 A/G cg19694781 chr19:47549865 TMEM160 -0.71 -6.74 -0.38 9.95e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.64 0.38 1.78e-10 Bipolar disorder; CESC cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg23711669 chr6:146136114 FBXO30 -0.93 -12.07 -0.6 4.93e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs4604732 0.631 rs74154672 chr1:247625625 C/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16791218 chr16:88105809 BANP 0.46 6.12 0.35 3.31e-9 Fibrinogen levels; CESC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg02891314 chr5:179741120 GFPT2 -0.63 -8.38 -0.46 3.08e-15 Height; CESC cis rs11252926 0.650 rs4880678 chr10:490472 G/A cg16386425 chr10:429943 DIP2C -0.49 -6.32 -0.36 1.1e-9 Psychosis in Alzheimer's disease; CESC cis rs2652834 0.904 rs8032506 chr15:63371644 G/A cg05507819 chr15:63340323 TPM1 -0.7 -6.32 -0.36 1.13e-9 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05759424 chr2:42721296 KCNG3 0.53 6.2 0.36 2.16e-9 Gut microbiome composition (summer); CESC cis rs9473147 0.516 rs10948363 chr6:47487762 A/G cg20196966 chr6:47445060 CD2AP 0.41 5.33 0.31 2.13e-7 Platelet distribution width;Mean platelet volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11559952 chr10:112064744 SMNDC1 -0.46 -6.06 -0.35 4.7e-9 Ulcerative colitis; CESC cis rs2361710 0.611 rs12451471 chr17:78102517 C/T cg06718696 chr17:78121285 EIF4A3 0.64 7.89 0.44 7.86e-14 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CESC cis rs8064299 0.636 rs9915279 chr17:72772848 T/C cg25054828 chr17:72772726 NAT9;TMEM104 0.87 14.53 0.67 1.37e-35 Monocyte count; CESC cis rs5758659 0.652 rs5758553 chr22:42431429 G/A cg19513890 chr22:42538836 CYP2D7P1 -0.39 -5.75 -0.33 2.46e-8 Cognitive function; CESC cis rs13082711 0.834 rs2172297 chr3:27428423 C/T cg02860705 chr3:27208620 NA 0.53 6.51 0.37 3.66e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg22800045 chr5:56110881 MAP3K1 0.83 10.09 0.53 1.85e-20 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19630102 chr14:68067023 PIGH 0.56 6.07 0.35 4.29e-9 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs1061343 chr17:29114276 G/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg26597838 chr10:835615 NA 1.18 11.47 0.58 5.21e-25 Eosinophil percentage of granulocytes; CESC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg25204440 chr1:209979598 IRF6 0.65 6.61 0.38 2.16e-10 Cleft lip with or without cleft palate; CESC cis rs9902453 0.904 rs7218379 chr17:28402737 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -9.08 -0.49 2.59e-17 Coffee consumption (cups per day); CESC cis rs709400 0.567 rs11624343 chr14:103859156 T/A cg12935359 chr14:103987150 CKB -0.5 -7.1 -0.4 1.12e-11 Body mass index; CESC trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -20.9 -0.79 5.71e-58 Height; CESC cis rs2380220 0.872 rs2613528 chr6:95939437 C/G cg15832292 chr6:96025679 MANEA -0.59 -5.17 -0.3 4.67e-7 Behavioural disinhibition (generation interaction); CESC cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg25894440 chr7:65020034 NA -0.61 -5.3 -0.31 2.42e-7 Diabetic kidney disease; CESC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg10494973 chr17:80897199 TBCD 0.5 5.76 0.33 2.31e-8 Breast cancer; CESC trans rs11098499 0.863 rs3822191 chr4:120428101 A/T cg25214090 chr10:38739885 LOC399744 0.71 9.7 0.51 3.06e-19 Corneal astigmatism; CESC cis rs9611565 0.694 rs202665 chr22:41814401 A/G cg03806693 chr22:41940476 POLR3H 1.16 14.61 0.67 7.1e-36 Vitiligo; CESC cis rs595982 0.559 rs73061632 chr19:49361663 G/A cg15549821 chr19:49342101 PLEKHA4 -0.7 -7.94 -0.44 5.83e-14 Red cell distribution width; CESC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 11.51 0.58 4.01e-25 Personality dimensions; CESC cis rs67311347 1.000 rs6762251 chr3:40531136 A/G cg24209194 chr3:40518798 ZNF619 -0.48 -6.14 -0.35 2.92e-9 Renal cell carcinoma; CESC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg03709012 chr19:19516395 GATAD2A 1.02 15.57 0.69 2.98e-39 Tonsillectomy; CESC cis rs963731 0.649 rs297143 chr2:39320067 T/C cg04010122 chr2:39346883 SOS1 -0.74 -5.39 -0.31 1.54e-7 Corticobasal degeneration; CESC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg13206674 chr6:150067644 NUP43 0.42 5.84 0.34 1.48e-8 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19839149 chr2:192542877 OBFC2A -0.5 -6.44 -0.37 5.65e-10 Fibrinogen levels; CESC cis rs7727544 0.735 rs274557 chr5:131721204 T/C cg24060327 chr5:131705240 SLC22A5 0.68 9.31 0.5 5.19e-18 Blood metabolite levels; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22029157 chr1:209979665 IRF6 0.8 15.43 0.69 9.32e-39 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs11048434 0.636 rs11047953 chr12:9064923 A/C cg04155231 chr12:9217510 LOC144571 0.33 5.34 0.31 2.03e-7 Sjögren's syndrome; CESC cis rs12410462 1.000 rs75652886 chr1:227654485 G/T cg04117972 chr1:227635322 NA 0.63 6.25 0.36 1.61e-9 Major depressive disorder; CESC cis rs977987 0.843 rs6564260 chr16:75447426 A/G cg03315344 chr16:75512273 CHST6 0.41 5.83 0.34 1.59e-8 Dupuytren's disease; CESC trans rs9929218 0.551 rs2296409 chr16:68713730 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.98 16.94 0.72 4.01e-44 Colorectal cancer; CESC cis rs7927771 1.000 rs11039412 chr11:47841581 G/A cg05585544 chr11:47624801 NA -0.49 -7.71 -0.43 2.62e-13 Subjective well-being; CESC cis rs12142240 0.698 rs17361791 chr1:46812519 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.29 0.36 1.33e-9 Menopause (age at onset); CESC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg00129232 chr17:37814104 STARD3 -0.6 -8.01 -0.44 3.61e-14 Glomerular filtration rate (creatinine); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25411849 chr6:89855994 PM20D2 0.44 6.15 0.35 2.9e-9 Gut microbiota (bacterial taxa); CESC cis rs78889164 1.000 rs7250283 chr19:33863386 C/T cg02272751 chr19:33882848 PEPD -0.5 -6.67 -0.38 1.5e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7124681 0.546 rs7941399 chr11:47890421 A/T cg18512352 chr11:47633146 NA 0.35 5.42 0.32 1.35e-7 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs853679 0.599 rs156743 chr6:27967089 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.81 6.71 0.38 1.18e-10 Depression; CESC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg12311346 chr5:56204834 C5orf35 -0.74 -8.78 -0.47 2.02e-16 Initial pursuit acceleration; CESC cis rs6732160 0.934 rs2421390 chr2:73379103 T/C cg01422370 chr2:73384389 NA 0.51 8.7 0.47 3.52e-16 Intelligence (multi-trait analysis); CESC cis rs826838 1.000 rs851934 chr12:39104453 G/T cg13010199 chr12:38710504 ALG10B -0.4 -5.4 -0.31 1.52e-7 Heart rate; CESC cis rs9611565 0.765 rs132914 chr22:41805749 T/C cg06634786 chr22:41940651 POLR3H 0.71 7.47 0.42 1.16e-12 Vitiligo; CESC cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg26874164 chr19:58962979 ZNF324B 0.57 8.1 0.45 2.05e-14 Uric acid clearance; CESC cis rs6539267 0.516 rs17218455 chr12:106716441 C/T cg00173435 chr12:106696525 TCP11L2 0.63 5.68 0.33 3.59e-8 Tourette syndrome; CESC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg25072359 chr17:41440525 NA 0.43 5.78 0.33 2.04e-8 Menopause (age at onset); CESC cis rs826838 0.967 rs34496261 chr12:39023829 G/A cg13010199 chr12:38710504 ALG10B 0.58 8.1 0.45 2.01e-14 Heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11644123 chr17:79936123 ASPSCR1 -0.55 -6.69 -0.38 1.32e-10 Gut microbiome composition (summer); CESC cis rs8180040 0.726 rs61729713 chr3:47027192 A/G cg27129171 chr3:47204927 SETD2 -0.63 -9.01 -0.48 4.25e-17 Colorectal cancer; CESC cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.91e-28 Colonoscopy-negative controls vs population controls; CESC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg21280719 chr6:42927975 GNMT 0.29 7.21 0.4 5.99e-12 Alzheimer's disease in APOE e4+ carriers; CESC cis rs12220238 1.000 rs10824085 chr10:75911984 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.45 0.37 5.41e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs1003719 0.788 rs2835575 chr21:38455936 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.67 0.47 4.41e-16 Eye color traits; CESC cis rs9902453 1.000 rs9897206 chr17:28406108 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.63 -8.05 -0.44 2.78e-14 Coffee consumption (cups per day); CESC cis rs17253792 0.822 rs10483646 chr14:56103872 A/C cg01858014 chr14:56050164 KTN1 -0.96 -6.51 -0.37 3.65e-10 Putamen volume; CESC cis rs7107174 1.000 rs2512549 chr11:77940163 A/G cg02023728 chr11:77925099 USP35 -0.46 -6.71 -0.38 1.17e-10 Testicular germ cell tumor; CESC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.09 11.83 0.59 3.18e-26 Gut microbiome composition (summer); CESC cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg00825309 chr19:58991885 ZNF446 -0.54 -7.71 -0.43 2.62e-13 Uric acid clearance; CESC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg04414720 chr1:150670196 GOLPH3L 0.51 6.81 0.39 6.39e-11 Melanoma; CESC cis rs854765 0.647 rs62073573 chr17:17976354 G/A cg16928487 chr17:17741425 SREBF1 -0.52 -8.27 -0.45 6.36e-15 Total body bone mineral density; CESC trans rs7937682 0.924 rs10891284 chr11:111527737 T/C cg18187862 chr3:45730750 SACM1L 0.48 6.08 0.35 4.15e-9 Primary sclerosing cholangitis; CESC cis rs7777484 0.534 rs2533888 chr7:2831083 T/C cg09658497 chr7:2847517 GNA12 -0.45 -7.04 -0.4 1.63e-11 Height; CESC cis rs854765 0.693 rs8079321 chr17:17760789 C/T cg09796270 chr17:17721594 SREBF1 0.4 5.81 0.34 1.79e-8 Total body bone mineral density; CESC cis rs2119480 0.731 rs369788 chr13:111305787 C/T cg16216153 chr13:111290848 CARKD -0.35 -5.27 -0.31 2.82e-7 Diastolic blood pressure; CESC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.69 -7.8 -0.43 1.42e-13 Gut microbiome composition (summer); CESC cis rs2979489 0.740 rs17554408 chr8:30427531 A/G cg26383811 chr8:30366931 RBPMS 0.76 9.05 0.49 3.24e-17 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.18 0.4 7.06e-12 Height; CESC cis rs2197308 0.765 rs117216293 chr12:37882982 T/C cg26384229 chr12:38710491 ALG10B -0.55 -7.82 -0.43 1.26e-13 Morning vs. evening chronotype; CESC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg05535760 chr7:792225 HEATR2 -0.78 -8.24 -0.45 8.16e-15 Cerebrospinal P-tau181p levels; CESC cis rs60154123 0.772 rs701942 chr1:210429392 C/G cg22029157 chr1:209979665 IRF6 0.49 5.75 0.33 2.4e-8 Coronary artery disease; CESC cis rs10504229 0.680 rs16921675 chr8:58052082 A/G cg24829409 chr8:58192753 C8orf71 -0.48 -6.1 -0.35 3.75e-9 Developmental language disorder (linguistic errors); CESC cis rs6690583 0.697 rs4907126 chr1:85523453 C/T cg11262906 chr1:85462892 MCOLN2 0.43 5.21 0.31 3.73e-7 Serum sulfate level; CESC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg17158414 chr2:27665306 KRTCAP3 -0.28 -5.35 -0.31 1.89e-7 Total body bone mineral density; CESC cis rs2404602 0.647 rs62026889 chr15:76917885 C/T cg23625390 chr15:77176239 SCAPER -0.45 -6.3 -0.36 1.26e-9 Blood metabolite levels; CESC cis rs75064307 0.834 rs4855562 chr3:108116835 C/T cg03329597 chr3:108125523 MYH15 0.52 5.91 0.34 1.05e-8 Intelligence (multi-trait analysis); CESC cis rs258892 0.793 rs56762233 chr5:72056882 A/G cg21869765 chr5:72125136 TNPO1 -0.42 -5.24 -0.31 3.2e-7 Small cell lung carcinoma; CESC cis rs7772486 0.806 rs7740785 chr6:146171299 C/A cg23711669 chr6:146136114 FBXO30 0.84 12.35 0.6 5.79e-28 Lobe attachment (rater-scored or self-reported); CESC trans rs9650657 0.645 rs11774552 chr8:10515679 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -6.44 -0.37 5.6e-10 Neuroticism; CESC cis rs28489187 0.706 rs233099 chr1:85826194 T/C cg16011679 chr1:85725395 C1orf52 0.48 5.55 0.32 7.04e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg24675658 chr1:53192096 ZYG11B 0.64 8.84 0.48 1.36e-16 Monocyte count; CESC cis rs9858542 1.000 rs9812791 chr3:49682311 G/A cg03060546 chr3:49711283 APEH -0.59 -6.96 -0.39 2.64e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs66530629 0.797 rs12758422 chr1:25078061 T/C cg22509179 chr1:25234806 RUNX3 -0.48 -6.21 -0.36 2.03e-9 Plateletcrit; CESC cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg02551604 chr5:131831745 NA -0.37 -5.27 -0.31 2.81e-7 Asthma (sex interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11255265 chr4:152246909 NA -0.59 -7.19 -0.4 6.78e-12 Gut microbiome composition (summer); CESC cis rs2108622 0.727 rs8101038 chr19:15982864 C/T cg13772218 chr19:15982569 NA 0.29 5.8 0.34 1.85e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs2735413 0.837 rs4888735 chr16:78083742 C/T cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC cis rs7590720 0.731 rs1864253 chr2:216878008 C/G cg12620499 chr2:216877984 MREG 0.96 15.3 0.68 2.71e-38 Alcohol dependence; CESC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg14298792 chr15:30685198 CHRFAM7A 0.43 5.2 0.3 3.98e-7 Huntington's disease progression; CESC cis rs1270639 0.778 rs2906930 chr7:157446453 T/C cg13357408 chr7:157437802 PTPRN2 0.61 7.15 0.4 8.33e-12 Colorectal cancer; CESC trans rs11098499 0.954 rs10518331 chr4:120323595 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC trans rs11039798 0.925 rs7929225 chr11:48931739 G/C cg15704280 chr7:45808275 SEPT13 0.7 6.56 0.37 2.74e-10 Axial length; CESC cis rs8114671 0.967 rs2378337 chr20:33771435 G/A cg24642439 chr20:33292090 TP53INP2 0.44 5.37 0.31 1.73e-7 Height; CESC cis rs9611519 0.828 rs4822008 chr22:41539206 C/G cg03806693 chr22:41940476 POLR3H -0.58 -5.89 -0.34 1.15e-8 Neuroticism; CESC cis rs1998418 0.736 rs4962401 chr10:126423706 G/A cg03585084 chr10:126284563 LHPP 0.43 5.03 0.3 9.08e-7 Mean platelet volume; CESC cis rs1045902 0.583 rs2303904 chr2:73447775 C/T cg01422370 chr2:73384389 NA -0.35 -5.55 -0.32 7.1e-8 Intelligence (multi-trait analysis); CESC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg08684580 chr7:98029266 BAIAP2L1 0.33 5.34 0.31 1.96e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs75477785 0.590 rs12073617 chr1:210259974 G/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.83 5.69 0.33 3.36e-8 Cleft lip with or without cleft palate; CESC cis rs3768617 0.510 rs723014 chr1:183076287 A/G ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.05e-34 Fuchs's corneal dystrophy; CESC cis rs793571 0.592 rs72745053 chr15:59159259 G/A cg05156742 chr15:59063176 FAM63B -0.6 -8.39 -0.46 3.03e-15 Schizophrenia; CESC cis rs6502050 0.871 rs6502051 chr17:80059332 A/C cg11859384 chr17:80120422 CCDC57 0.39 5.49 0.32 9.6e-8 Life satisfaction; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06062848 chr18:60194352 ZCCHC2 0.46 6.01 0.35 6.12e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17666538 0.792 rs1703912 chr8:600643 A/G cg07234876 chr8:600039 NA 0.82 6.47 0.37 4.82e-10 IgG glycosylation; CESC cis rs4664304 0.900 rs3828327 chr2:160742095 G/A cg03641300 chr2:160917029 PLA2R1 -0.46 -6.48 -0.37 4.57e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs11098499 0.874 rs17839089 chr4:120111069 A/G cg09307838 chr4:120376055 NA 0.67 8.32 0.45 4.79e-15 Corneal astigmatism; CESC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg12463550 chr7:65579703 CRCP -0.47 -6.08 -0.35 4.28e-9 Aortic root size; CESC cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.1 0.49 2.28e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs524281 0.731 rs2276036 chr11:66033430 C/T cg14036092 chr11:66035641 RAB1B -0.54 -5.34 -0.31 2.03e-7 Electroencephalogram traits; CESC cis rs7824557 0.527 rs4634600 chr8:11239017 T/A cg21775007 chr8:11205619 TDH -0.52 -7.89 -0.44 7.81e-14 Retinal vascular caliber; CESC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg04944784 chr2:26401820 FAM59B 0.75 8.11 0.45 1.85e-14 Gut microbiome composition (summer); CESC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs1814175 0.586 rs2866862 chr11:49954588 T/C cg11707556 chr5:10655725 ANKRD33B -0.41 -6.15 -0.35 2.82e-9 Height; CESC cis rs2836633 0.929 rs62217517 chr21:40033177 T/A cg12884169 chr21:40033163 ERG 0.38 5.99 0.35 6.69e-9 Coronary artery disease; CESC cis rs738322 0.967 rs132971 chr22:38561911 T/G cg17652424 chr22:38574118 PLA2G6 -0.34 -6.16 -0.35 2.71e-9 Cutaneous nevi; CESC cis rs9660992 0.686 rs1668870 chr1:205239031 C/G cg21643547 chr1:205240462 TMCC2 -0.47 -6.34 -0.36 1.01e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs901683 1.000 rs12779281 chr10:45977447 T/C cg16031567 chr10:46195673 NA -0.75 -5.04 -0.3 8.78e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs1707322 0.721 rs12091503 chr1:46107868 T/C cg05343316 chr1:45956843 TESK2 0.51 6.22 0.36 1.91e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs67311347 1.000 rs12633431 chr3:40505740 C/T cg01475735 chr3:40494733 NA 0.43 5.32 0.31 2.18e-7 Renal cell carcinoma; CESC cis rs1707322 0.963 rs10789484 chr1:46406978 G/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs72634258 0.945 rs161802 chr1:8042826 G/T cg00042356 chr1:8021962 PARK7 0.46 5.24 0.31 3.24e-7 Inflammatory bowel disease; CESC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg10819733 chr22:24237672 NA -0.35 -5.07 -0.3 7.33e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4718428 0.705 rs11028 chr7:66276217 T/C cg25985355 chr7:65971099 NA -0.35 -5.14 -0.3 5.27e-7 Corneal structure; CESC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.56 -0.32 6.6e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg06108461 chr20:60628389 TAF4 -0.81 -11.72 -0.58 7.56e-26 Body mass index; CESC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg09359103 chr1:154839909 KCNN3 -0.66 -12.34 -0.6 5.93e-28 Prostate cancer; CESC cis rs7546094 1.000 rs12126277 chr1:113106369 A/G cg22162597 chr1:113214053 CAPZA1 0.37 5.67 0.33 3.69e-8 Platelet distribution width; CESC trans rs4596713 0.538 rs10125494 chr9:71770861 C/G cg16512924 chr15:28394682 HERC2 0.5 6.29 0.36 1.33e-9 Headache; CESC cis rs854765 0.583 rs6502622 chr17:17834691 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.56 7.98 0.44 4.3e-14 Total body bone mineral density; CESC cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.14e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 0.966 rs3775927 chr4:17599894 G/T cg04450456 chr4:17643702 FAM184B 0.36 5.1 0.3 6.6e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1934955 0.537 rs7097433 chr10:96776966 C/T cg09036531 chr10:96991505 NA -0.37 -5.07 -0.3 7.45e-7 Blood metabolite levels; CESC trans rs6021270 0.678 rs6021264 chr20:50134683 C/T cg05339727 chr2:165812079 SLC38A11 0.74 6.34 0.36 9.63e-10 Self-reported allergy; CESC cis rs55882075 0.967 rs62404346 chr5:179141391 A/C cg14593053 chr5:179126677 CANX 0.46 6.03 0.35 5.46e-9 Monocyte percentage of white cells; CESC cis rs17826219 0.706 rs609472 chr17:28951427 T/C cg14008862 chr17:28927542 LRRC37B2 0.7 6.26 0.36 1.53e-9 Body mass index; CESC cis rs3733585 0.736 rs4543113 chr4:10008305 G/A cg02734326 chr4:10020555 SLC2A9 0.47 6.43 0.37 5.87e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs61931739 0.517 rs10844802 chr12:34231001 C/A cg19457237 chr12:34500585 NA -0.38 -5.29 -0.31 2.52e-7 Morning vs. evening chronotype; CESC cis rs763014 0.865 rs8675 chr16:633843 A/G cg07256732 chr16:621771 PIGQ -0.3 -5.15 -0.3 5.06e-7 Height; CESC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg15445000 chr17:37608096 MED1 0.39 6.46 0.37 5.01e-10 Glomerular filtration rate (creatinine); CESC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg22800045 chr5:56110881 MAP3K1 0.62 7.56 0.42 6.71e-13 Type 2 diabetes; CESC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg00129232 chr17:37814104 STARD3 0.54 6.57 0.37 2.66e-10 Glomerular filtration rate (creatinine); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05046026 chr11:61559981 C11orf10;FEN1;MIR611 -0.5 -6.97 -0.39 2.55e-11 Fibrinogen levels; CESC cis rs684232 0.583 rs2657626 chr17:603052 A/G cg12384639 chr17:618140 VPS53 0.4 5.3 0.31 2.48e-7 Prostate cancer; CESC trans rs561341 0.689 rs578635 chr17:30289897 A/C cg20587970 chr11:113659929 NA -0.56 -7.18 -0.4 6.87e-12 Hip circumference adjusted for BMI; CESC trans rs2727020 0.636 rs11040368 chr11:49453602 C/A cg03929089 chr4:120376271 NA -0.82 -12.78 -0.62 1.78e-29 Coronary artery disease; CESC cis rs9640161 0.789 rs10952250 chr7:150025966 T/C cg10018233 chr7:150070692 REPIN1 0.44 7.32 0.41 2.96e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs4423214 1.000 rs2276360 chr11:71169547 C/G cg05163923 chr11:71159392 DHCR7 0.8 11.04 0.56 1.41e-23 Vitamin D levels; CESC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.12 0.3 5.85e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg25036284 chr2:26402008 FAM59B -0.8 -9.57 -0.51 8.13e-19 Gut microbiome composition (summer); CESC cis rs9583531 0.600 rs7330080 chr13:111367115 C/T cg24331049 chr13:111365604 ING1 0.71 10.88 0.56 5.07e-23 Coronary artery disease; CESC cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg18850127 chr7:39170497 POU6F2 0.37 5.18 0.3 4.43e-7 IgG glycosylation; CESC cis rs9815354 0.857 rs9816772 chr3:41872877 C/T cg03022575 chr3:42003672 ULK4 0.49 5.52 0.32 7.99e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.76 12.31 0.6 7.38e-28 Personality dimensions; CESC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.61 6.91 0.39 3.69e-11 Lung function (FEV1/FVC); CESC cis rs2204008 0.837 rs11168504 chr12:37964922 G/T cg26384229 chr12:38710491 ALG10B 0.73 10.65 0.55 2.71e-22 Bladder cancer; CESC cis rs1670533 1.000 rs7660779 chr4:1075940 A/G cg27284194 chr4:1044797 NA 0.48 6.06 0.35 4.69e-9 Recombination rate (females); CESC cis rs4330281 0.765 rs7645459 chr3:17808236 C/G cg20981856 chr3:17787350 NA 0.38 5.4 0.31 1.49e-7 Schizophrenia; CESC cis rs644799 0.544 rs1727165 chr11:95521648 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.61 8.27 0.45 6.69e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs748404 0.660 rs690012 chr15:43719755 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.58 7.55 0.42 7.18e-13 Lung cancer; CESC cis rs9858542 0.953 rs9824092 chr3:49674147 C/G cg03060546 chr3:49711283 APEH -0.57 -6.74 -0.38 9.8e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4588572 0.570 rs6453389 chr5:77727003 T/G cg11547950 chr5:77652471 NA -0.4 -5.56 -0.32 6.68e-8 Triglycerides; CESC cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.15e-15 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs977987 0.806 rs35683383 chr16:75479277 G/T cg03315344 chr16:75512273 CHST6 0.45 6.55 0.37 2.97e-10 Dupuytren's disease; CESC cis rs3820068 0.532 rs78917815 chr1:15920821 A/G cg17385448 chr1:15911702 AGMAT 0.42 6.72 0.38 1.13e-10 Systolic blood pressure; CESC cis rs12249377 0.519 rs11599902 chr10:92598823 A/G cg14313238 chr10:92632228 RPP30 0.45 5.63 0.33 4.62e-8 White matter microstructure (global fractional anisotropy); CESC trans rs208520 0.661 rs4710566 chr6:66848538 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -13.15 -0.63 9.82e-31 Exhaled nitric oxide output; CESC trans rs694739 0.726 rs17857342 chr11:64138905 T/G cg01888411 chr11:34378293 ABTB2 0.4 6.1 0.35 3.79e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25390656 chr10:92980550 PCGF5 0.53 6.2 0.36 2.21e-9 Gut microbiome composition (summer); CESC cis rs9303542 0.559 rs35621842 chr17:46606222 C/T cg04904318 chr17:46607828 HOXB1 -0.64 -6.33 -0.36 1.05e-9 Ovarian cancer;Epithelial ovarian cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16322581 chr12:70636648 CNOT2 0.6 7.33 0.41 2.77e-12 Gut microbiome composition (summer); CESC cis rs3106136 0.527 rs4235050 chr4:95157156 A/G cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Capecitabine sensitivity; CESC cis rs4595586 0.545 rs6580910 chr12:39390052 C/A cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs6714710 0.603 rs116309486 chr2:98493359 A/G cg26665480 chr2:98280029 ACTR1B 0.6 8.14 0.45 1.57e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs959260 0.557 rs12946365 chr17:73317644 C/T cg20590849 chr17:73267439 MIF4GD -0.43 -5.39 -0.31 1.57e-7 Systemic lupus erythematosus; CESC cis rs1670533 1.000 rs2100411 chr4:1074412 T/C cg27284194 chr4:1044797 NA 0.47 5.91 0.34 1.04e-8 Recombination rate (females); CESC cis rs7107174 0.901 rs7941639 chr11:78116959 A/G cg02023728 chr11:77925099 USP35 -0.45 -6.13 -0.35 3.09e-9 Testicular germ cell tumor; CESC cis rs9443189 0.774 rs2647405 chr6:76450023 C/T cg01950844 chr6:76311363 SENP6 -0.59 -6.53 -0.37 3.32e-10 Prostate cancer; CESC cis rs7772486 0.790 rs1854900 chr6:146331382 G/A cg23711669 chr6:146136114 FBXO30 0.83 12.15 0.6 2.6e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs2235642 0.893 rs2076445 chr16:1592266 A/T cg03771183 chr16:1608904 IFT140 0.41 5.92 0.34 1.02e-8 Coronary artery disease; CESC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.64 8.94 0.48 6.76e-17 Menarche (age at onset); CESC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg06873352 chr17:61820015 STRADA 0.66 11.67 0.58 1.17e-25 Prudent dietary pattern; CESC cis rs2230307 0.572 rs11805428 chr1:100641716 T/C cg24955406 chr1:100503596 HIAT1 -0.5 -5.03 -0.3 9.2e-7 Carotid intima media thickness; CESC cis rs7520050 0.807 rs5021934 chr1:46109304 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -6.08 -0.35 4.22e-9 Red blood cell count;Reticulocyte count; CESC cis rs7107174 1.000 rs7939646 chr11:78111613 C/T cg02023728 chr11:77925099 USP35 -0.37 -5.3 -0.31 2.49e-7 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13975660 chr4:114681840 CAMK2D -0.52 -6.02 -0.35 5.79e-9 Gut microbiome composition (summer); CESC cis rs634534 0.532 rs12794370 chr11:65770413 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.47 6.47 0.37 4.71e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs897984 0.762 rs7204459 chr16:30984212 G/A cg02466173 chr16:30829666 NA 0.48 8.1 0.45 1.99e-14 Dementia with Lewy bodies; CESC cis rs4812048 0.649 rs3761257 chr20:57618787 C/T cg14073986 chr20:57617431 SLMO2 0.85 7.61 0.42 4.71e-13 Mean platelet volume; CESC cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg20307385 chr11:47447363 PSMC3 -0.6 -7.31 -0.41 3.23e-12 Subjective well-being; CESC cis rs8114671 0.901 rs6119581 chr20:33773689 T/A cg24642439 chr20:33292090 TP53INP2 0.44 5.29 0.31 2.55e-7 Height; CESC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg18230493 chr5:56204884 C5orf35 -0.73 -8.57 -0.47 8.93e-16 Initial pursuit acceleration; CESC trans rs27434 0.561 rs35134 chr5:96159523 A/G cg13971232 chr2:236901460 AGAP1 0.41 6.24 0.36 1.77e-9 Ankylosing spondylitis; CESC cis rs9487051 0.676 rs6568560 chr6:109592851 G/A cg01475377 chr6:109611718 NA -0.44 -6.99 -0.39 2.19e-11 Reticulocyte fraction of red cells; CESC cis rs4566357 0.615 rs10190621 chr2:227914484 A/G cg05526886 chr2:227700861 RHBDD1 -0.46 -6.1 -0.35 3.74e-9 Coronary artery disease; CESC cis rs8072100 0.967 rs8072644 chr17:45653364 A/T cg08085267 chr17:45401833 C17orf57 0.39 5.12 0.3 5.76e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6736093 0.769 rs56361454 chr2:112774105 C/T cg12686935 chr2:112915763 FBLN7 -0.38 -5.24 -0.31 3.26e-7 Coronary artery disease; CESC trans rs11088226 0.681 rs1134747 chr21:33939011 T/A cg09050820 chr6:167586206 TCP10L2 0.83 7.75 0.43 2.01e-13 Gastritis; CESC cis rs1018836 0.828 rs9297870 chr8:91570691 C/G cg16814680 chr8:91681699 NA -0.63 -9.19 -0.49 1.15e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1023500 0.529 rs133375 chr22:42466509 C/G cg04733989 chr22:42467013 NAGA 0.79 12.05 0.59 5.98e-27 Schizophrenia; CESC cis rs2932538 0.961 rs2932529 chr1:113193364 G/A cg22162597 chr1:113214053 CAPZA1 -0.6 -7.51 -0.42 8.99e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC trans rs7902708 0.920 rs74133652 chr10:54424356 G/C cg26219051 chr22:43739629 SCUBE1 -0.49 -6.32 -0.36 1.09e-9 Bone properties (heel); CESC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg08859206 chr1:53392774 SCP2 0.54 7.13 0.4 9.54e-12 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20044189 chr5:141704548 SPRY4 0.58 6.6 0.38 2.22e-10 Gut microbiome composition (summer); CESC cis rs4919694 0.667 rs117927731 chr10:105112852 C/A cg04362960 chr10:104952993 NT5C2 0.71 5.69 0.33 3.44e-8 Arsenic metabolism; CESC cis rs7020830 0.825 rs10973248 chr9:37197768 C/T cg14294708 chr9:37120828 ZCCHC7 1.22 23.77 0.83 1.14e-67 Schizophrenia; CESC cis rs9443645 0.901 rs9448580 chr6:79551812 C/G cg05283184 chr6:79620031 NA -0.44 -6.84 -0.39 5.42e-11 Intelligence (multi-trait analysis); CESC cis rs17401966 0.838 rs4333852 chr1:10387704 A/T cg15208524 chr1:10270712 KIF1B -0.4 -5.18 -0.3 4.43e-7 Hepatocellular carcinoma; CESC cis rs116095464 0.867 rs7726582 chr5:215349 C/G cg10591111 chr5:226296 SDHA -0.52 -6.43 -0.37 5.91e-10 Breast cancer; CESC trans rs4568518 0.740 rs11543650 chr7:18009880 T/C cg27060346 chr2:234359958 DGKD -0.42 -6.01 -0.35 6.27e-9 Measles; CESC cis rs7665939 1.000 rs11942826 chr4:190109362 C/T cg09826759 chr4:190284978 NA -0.76 -7.68 -0.43 3.1e-13 Amyotrophic lateral sclerosis; CESC cis rs10927875 0.832 rs4661342 chr1:16160773 C/G cg21385522 chr1:16154831 NA -0.92 -11.48 -0.58 4.86e-25 Dilated cardiomyopathy; CESC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs2286503 0.780 rs2240727 chr7:22852512 C/T cg11367502 chr7:22862612 TOMM7 0.39 5.1 0.3 6.41e-7 Fibrinogen; CESC cis rs2839186 0.934 rs17176520 chr21:47682081 T/C cg10351095 chr21:47802916 PCNT -0.52 -7.02 -0.4 1.82e-11 Testicular germ cell tumor; CESC cis rs1034435 0.755 rs9615336 chr22:48893090 G/C cg05992904 chr22:48892994 FAM19A5 -0.57 -9.8 -0.52 1.53e-19 Late-onset Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25935716 chr20:30102579 HM13 0.58 6.09 0.35 3.88e-9 Gut microbiome composition (summer); CESC cis rs425277 1.000 rs262651 chr1:2091397 A/G cg04315214 chr1:2043799 PRKCZ -0.38 -5.31 -0.31 2.35e-7 Height; CESC cis rs2070488 0.965 rs3762788 chr3:38493852 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.94 17.16 0.73 6.61e-45 Electrocardiographic conduction measures; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26528255 chr1:27652089 TMEM222 -0.66 -7.4 -0.41 1.84e-12 Gut microbiome composition (summer); CESC cis rs6963495 0.519 rs3892297 chr7:105152173 G/A cg02135003 chr7:105160482 PUS7 -0.46 -5.48 -0.32 9.86e-8 Bipolar disorder (body mass index interaction); CESC cis rs6089584 0.566 rs6061964 chr20:60607536 G/A cg06108461 chr20:60628389 TAF4 -0.62 -8.19 -0.45 1.14e-14 Body mass index; CESC cis rs11112613 0.713 rs68053161 chr12:105950035 G/C cg03607813 chr12:105948248 NA 0.67 8.31 0.45 5.16e-15 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs6570726 0.935 rs419847 chr6:145827278 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.21e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7246657 0.943 rs7255785 chr19:37971683 C/T cg23950597 chr19:37808831 NA -0.58 -6.44 -0.37 5.71e-10 Coronary artery calcification; CESC cis rs3768617 0.510 rs10911239 chr1:183062450 T/C ch.1.3577855R chr1:183094577 LAMC1 0.88 14.25 0.66 1.3600000000000001e-34 Fuchs's corneal dystrophy; CESC cis rs921968 1.000 rs921968 chr2:219272294 G/T cg02176678 chr2:219576539 TTLL4 0.34 5.85 0.34 1.47e-8 Mean corpuscular hemoglobin concentration; CESC cis rs1707322 0.721 rs11211163 chr1:46153548 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9896933 0.778 rs80112422 chr17:80827719 G/T cg15664640 chr17:80829946 TBCD -0.53 -5.62 -0.33 4.83e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs921968 0.541 rs10200507 chr2:219335944 C/A cg02176678 chr2:219576539 TTLL4 -0.54 -9.87 -0.52 9.03e-20 Mean corpuscular hemoglobin concentration; CESC cis rs9911578 0.935 rs7218105 chr17:57041119 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.24 0.68 4.34e-38 Intelligence (multi-trait analysis); CESC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg02935154 chr7:12443704 VWDE -0.59 -6.31 -0.36 1.14e-9 Coronary artery disease; CESC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg18350739 chr11:68623251 NA 0.38 5.65 0.33 4.17e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2708240 0.936 rs2708241 chr7:147578931 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.78 -0.33 2.12e-8 QT interval (drug interaction); CESC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg03146154 chr1:46216737 IPP -0.43 -5.37 -0.31 1.73e-7 High light scatter reticulocyte count; CESC cis rs7267979 0.966 rs2261794 chr20:25263062 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs2522056 0.932 rs2522064 chr5:131806488 G/A cg07395648 chr5:131743802 NA 0.44 5.04 0.3 8.53e-7 Lymphocyte counts;Fibrinogen; CESC cis rs2299587 0.543 rs12546204 chr8:17796871 A/C cg08627089 chr8:17753878 FGL1 -0.41 -5.51 -0.32 8.7e-8 Economic and political preferences; CESC cis rs734999 0.545 rs10797436 chr1:2538349 G/A cg18854424 chr1:2615690 NA 0.3 5.81 0.34 1.82e-8 Ulcerative colitis; CESC cis rs1707322 1.000 rs785517 chr1:46567535 A/T cg03146154 chr1:46216737 IPP -0.74 -9.64 -0.51 4.75e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1005277 0.579 rs1780116 chr10:38526621 C/T cg25427524 chr10:38739819 LOC399744 -0.7 -10.26 -0.53 5.29e-21 Extrinsic epigenetic age acceleration; CESC cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg07636037 chr3:49044803 WDR6 1.06 18.4 0.75 2.81e-49 Parkinson's disease; CESC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.24 -0.36 1.77e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2952156 0.876 rs903504 chr17:37829570 C/G cg20243544 chr17:37824526 PNMT 0.63 8.15 0.45 1.47e-14 Asthma; CESC trans rs4843747 0.619 rs66508972 chr16:88086385 C/G cg26811252 chr16:29126840 RRN3P2 0.69 9.39 0.5 2.85e-18 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04272052 chr7:99662051 ZNF3;ZSCAN21 -0.68 -7.79 -0.43 1.51e-13 Gut microbiome composition (summer); CESC trans rs4942242 0.967 rs58325557 chr13:44217771 A/G cg19169023 chr15:41853346 TYRO3 0.46 6.61 0.38 2.05e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9611565 0.559 rs7290991 chr22:41964361 C/G cg06634786 chr22:41940651 POLR3H -0.62 -6.83 -0.39 5.85e-11 Vitiligo; CESC cis rs7208859 0.623 rs55814012 chr17:29077697 T/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12926788 0.689 rs7186308 chr16:24848471 A/G cg02428538 chr16:24856791 SLC5A11 -0.56 -6.08 -0.35 4.14e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9348729 1 rs9348729 chr6:26664268 T/C cg12292205 chr6:26970375 C6orf41 -0.54 -5.98 -0.34 7.34e-9 Intelligence (multi-trait analysis); CESC cis rs1218582 0.661 rs4845695 chr1:154911798 A/G cg24250549 chr1:154909240 PMVK 0.57 7.6 0.42 5.29e-13 Prostate cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24258716 chr8:143820480 NA -0.46 -6.64 -0.38 1.79e-10 Gambling; CESC cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg16447950 chr5:562315 NA -0.62 -6.52 -0.37 3.54e-10 Lung disease severity in cystic fibrosis; CESC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg24675658 chr1:53192096 ZYG11B 0.57 7.24 0.41 4.86e-12 Monocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14650514 chr9:33290567 SUGT1P1;NFX1 -0.43 -6.11 -0.35 3.55e-9 Gambling; CESC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg18402987 chr7:1209562 NA 0.73 7.24 0.41 4.93e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10788264 0.544 rs9630083 chr10:124017423 C/T cg09507567 chr10:124027408 NA 0.45 6.23 0.36 1.85e-9 Total body bone mineral density; CESC cis rs2479724 0.901 rs2185798 chr6:41773576 G/C cg17623882 chr6:41773611 USP49 0.41 5.88 0.34 1.23e-8 Menarche (age at onset); CESC cis rs13191362 0.507 rs2849527 chr6:163117932 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.51 6.13 0.35 3.11e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2479106 0.791 rs4838083 chr9:126714308 A/C cg16191174 chr9:126692580 DENND1A -0.41 -5.48 -0.32 1.01e-7 Polycystic ovary syndrome; CESC cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg23711669 chr6:146136114 FBXO30 1.01 15.49 0.69 5.86e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs2072732 0.861 rs55873718 chr1:2940012 A/G cg15211996 chr1:2936768 ACTRT2 0.35 5.74 0.33 2.56e-8 Plateletcrit; CESC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg04267008 chr7:1944627 MAD1L1 -0.56 -7.07 -0.4 1.4e-11 Bipolar disorder and schizophrenia; CESC cis rs2070677 0.935 rs11101869 chr10:135400631 C/T cg20169779 chr10:135381914 SYCE1 -0.77 -10.36 -0.54 2.46e-21 Gout; CESC cis rs2708240 1.000 rs2538987 chr7:147580505 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.36 -5.99 -0.35 6.79e-9 QT interval (drug interaction); CESC cis rs7618501 1.000 rs7374277 chr3:49784777 T/C cg24308560 chr3:49941425 MST1R 0.5 6.71 0.38 1.15e-10 Intelligence (multi-trait analysis); CESC cis rs9303401 0.646 rs9303403 chr17:57219300 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.51 -6.22 -0.36 1.88e-9 Cognitive test performance; CESC cis rs17826219 0.706 rs73271850 chr17:29142140 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Body mass index; CESC cis rs8060686 0.641 rs59708959 chr16:68123916 A/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.0 -0.35 6.53e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs854765 0.647 rs7406744 chr17:17981938 C/G cg09796270 chr17:17721594 SREBF1 0.38 5.08 0.3 7.23e-7 Total body bone mineral density; CESC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg02038168 chr22:39784481 NA -0.62 -7.66 -0.43 3.51e-13 Intelligence (multi-trait analysis); CESC cis rs71277158 0.688 rs2287483 chr3:169756846 C/T cg04067573 chr3:169899625 PHC3 0.55 5.48 0.32 9.92e-8 Prostate cancer; CESC trans rs629535 0.821 rs497398 chr8:70037434 A/T cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg24549020 chr5:56110836 MAP3K1 0.66 7.45 0.42 1.29e-12 Initial pursuit acceleration; CESC cis rs9584850 1.000 rs9584850 chr13:99101426 G/C cg20750642 chr13:99100586 FARP1 -0.38 -5.74 -0.33 2.61e-8 Neuroticism; CESC cis rs4642101 0.765 rs4321514 chr3:12825901 C/T cg24848339 chr3:12840334 CAND2 0.38 5.94 0.34 8.89e-9 QRS complex (12-leadsum); CESC cis rs16957304 0.744 rs9934827 chr16:67413003 A/T cg26727032 chr16:67993705 SLC12A4 -0.51 -5.07 -0.3 7.36e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs2072732 0.861 rs12567620 chr1:2956999 T/G cg15211996 chr1:2936768 ACTRT2 0.33 5.91 0.34 1.07e-8 Plateletcrit; CESC cis rs950776 0.593 rs588765 chr15:78865425 T/C cg24631222 chr15:78858424 CHRNA5 0.43 5.44 0.32 1.24e-7 Sudden cardiac arrest; CESC cis rs6831352 0.879 rs56295995 chr4:100060899 C/T cg12011299 chr4:100065546 ADH4 -0.59 -6.59 -0.38 2.35e-10 Alcohol dependence; CESC cis rs7100689 0.646 rs1340380 chr10:82115619 T/C cg00277334 chr10:82204260 NA -0.59 -7.63 -0.42 4.35e-13 Post bronchodilator FEV1; CESC cis rs12545109 0.800 rs1960725 chr8:57411807 C/T cg09654669 chr8:57350985 NA -0.46 -6.28 -0.36 1.4e-9 Obesity-related traits; CESC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg26441486 chr22:50317300 CRELD2 0.38 5.37 0.31 1.76e-7 Schizophrenia; CESC trans rs3780486 0.505 rs10758188 chr9:33123386 C/T cg20290983 chr6:43655470 MRPS18A -0.77 -12.33 -0.6 6.58e-28 IgG glycosylation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13284045 chr12:860787 WNK1 0.46 6.59 0.38 2.42e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs62103177 0.608 rs59300126 chr18:77694439 C/A cg12964065 chr18:77638022 KCNG2 0.47 5.1 0.3 6.36e-7 Opioid sensitivity; CESC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg18490616 chr2:88469792 THNSL2 0.56 5.41 0.32 1.38e-7 Plasma clusterin levels; CESC trans rs9650657 0.645 rs4841408 chr8:10516336 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -6.43 -0.37 5.87e-10 Neuroticism; CESC cis rs854765 0.583 rs7207043 chr17:17819188 A/G cg04398451 chr17:18023971 MYO15A -0.67 -9.74 -0.51 2.33e-19 Total body bone mineral density; CESC cis rs1371867 0.846 rs1788204 chr8:101303936 C/T cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.24e-11 Atrioventricular conduction; CESC cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg22875332 chr1:76189707 ACADM -0.63 -6.04 -0.35 5.29e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg22105103 chr4:187893119 NA -0.45 -6.64 -0.38 1.73e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs561341 0.941 rs2428336 chr17:30290577 T/C cg12193833 chr17:30244370 NA -0.62 -6.23 -0.36 1.84e-9 Hip circumference adjusted for BMI; CESC cis rs1570884 0.556 rs2146146 chr13:50170368 C/T cg08779649 chr13:50194554 NA 0.39 6.71 0.38 1.17e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs829883 0.646 rs249838 chr12:98874749 C/G cg25150519 chr12:98850993 NA 0.41 5.27 0.31 2.85e-7 Colorectal adenoma (advanced); CESC cis rs11785400 1.000 rs10099892 chr8:143734608 C/T cg10596483 chr8:143751796 JRK 0.43 5.6 0.33 5.24e-8 Schizophrenia; CESC cis rs870825 0.549 rs7699919 chr4:185648610 A/C cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs11190604 1.000 rs10883507 chr10:102291275 C/T cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg23048001 chr7:2026167 MAD1L1 0.44 5.73 0.33 2.75e-8 Bipolar disorder and schizophrenia; CESC cis rs7584330 0.737 rs13397017 chr2:238361241 G/A cg14458575 chr2:238380390 NA 0.6 8.32 0.46 4.61e-15 Prostate cancer; CESC cis rs2637266 1.000 rs2579746 chr10:78327674 C/T cg18941641 chr10:78392320 NA 0.4 7.43 0.42 1.51e-12 Pulmonary function; CESC cis rs1707322 0.752 rs4660880 chr1:46111040 C/T cg03146154 chr1:46216737 IPP 0.85 12.19 0.6 2.03e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9300255 0.602 rs4372492 chr12:123697357 T/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.51 -0.37 3.65e-10 Neutrophil percentage of white cells; CESC cis rs12530845 1.000 rs12537555 chr7:135334061 G/A cg23117316 chr7:135346802 PL-5283 -0.43 -5.33 -0.31 2.13e-7 Red blood cell traits; CESC cis rs5769765 0.773 rs4075331 chr22:50302850 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.48 -5.42 -0.32 1.35e-7 Schizophrenia; CESC cis rs7539624 0.588 rs10916600 chr1:223897012 C/T cg10100437 chr1:223903862 CAPN2 0.43 5.55 0.32 7.08e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05642746 chr17:8024095 HES7 -0.58 -6.64 -0.38 1.81e-10 Gut microbiome composition (summer); CESC cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg15556689 chr8:8085844 FLJ10661 0.53 6.45 0.37 5.3e-10 Mood instability; CESC cis rs524023 0.957 rs10792443 chr11:64395252 G/C cg07220939 chr11:64358617 SLC22A12 -0.35 -5.42 -0.32 1.32e-7 Urate levels in obese individuals; CESC cis rs8017423 0.935 rs4643251 chr14:90669256 C/T cg14092571 chr14:90743983 NA 0.51 7.58 0.42 5.73e-13 Mortality in heart failure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00114008 chr1:27114423 PIGV 0.59 6.63 0.38 1.89e-10 Gut microbiome composition (summer); CESC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg24733560 chr20:60626293 TAF4 -0.42 -5.74 -0.33 2.53e-8 Body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15188491 chr1:146644106 PRKAB2 -0.48 -6.87 -0.39 4.65e-11 Gambling; CESC cis rs853679 0.599 rs202906 chr6:28011652 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL -0.76 -6.29 -0.36 1.29e-9 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09511246 chr2:172290755 DCAF17;METTL8 0.62 6.83 0.39 5.86e-11 Gut microbiome composition (summer); CESC cis rs853679 0.882 rs4713140 chr6:28097193 C/T cg18032046 chr6:28092343 ZSCAN16 -0.67 -6.06 -0.35 4.75e-9 Depression; CESC cis rs727505 0.564 rs68107250 chr7:124870200 G/A cg23710748 chr7:124431027 NA -0.34 -5.19 -0.3 4.19e-7 Lewy body disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07387570 chr22:46663686 TTC38 0.46 6.24 0.36 1.74e-9 Systemic lupus erythematosus; CESC cis rs7793919 0.652 rs10228886 chr7:4783224 C/T cg09789173 chr7:4769017 FOXK1 -0.61 -8.7 -0.47 3.55e-16 Mosquito bite size; CESC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.573 rs4055105 chr17:29102550 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg10691866 chr7:65817282 TPST1 -0.34 -5.46 -0.32 1.12e-7 Aortic root size; CESC cis rs929354 0.772 rs7778193 chr7:156980087 C/T cg05182265 chr7:156933206 UBE3C -0.51 -7.52 -0.42 8.49e-13 Body mass index; CESC cis rs60154123 0.686 rs227222 chr1:210191272 T/C cg25204440 chr1:209979598 IRF6 -0.68 -5.38 -0.31 1.65e-7 Coronary artery disease; CESC cis rs11792861 0.926 rs7470160 chr9:111844246 C/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 5.18 0.3 4.44e-7 Menarche (age at onset); CESC cis rs9488822 0.676 rs1999929 chr6:116381994 T/C cg26893134 chr6:116381904 FRK 0.25 6.14 0.35 3.05e-9 Cholesterol, total;LDL cholesterol; CESC cis rs2304069 1.000 rs216126 chr5:149428424 G/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.77 9.97 0.52 4.3e-20 HIV-1 control; CESC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg22907277 chr7:1156413 C7orf50 0.35 5.19 0.3 4.22e-7 Longevity;Endometriosis; CESC cis rs9388451 0.626 rs9385383 chr6:126086290 G/T cg05901451 chr6:126070800 HEY2 -0.57 -8.46 -0.46 1.85e-15 Brugada syndrome; CESC cis rs6690583 1.000 rs6690464 chr1:85466369 A/G cg11262906 chr1:85462892 MCOLN2 -0.53 -6.01 -0.35 5.99e-9 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12593394 chr1:19923846 C1orf151 0.6 6.58 0.37 2.46e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs2254257 chr6:146203724 C/T cg23711669 chr6:146136114 FBXO30 0.94 13.98 0.65 1.23e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs12824058 0.737 rs11060829 chr12:130814996 G/T cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg24838063 chr12:130822603 PIWIL1 0.62 8.54 0.46 1.09e-15 Menopause (age at onset); CESC cis rs28489187 0.683 rs2177461 chr1:85861976 C/G cg16011679 chr1:85725395 C1orf52 -0.46 -5.55 -0.32 6.87e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs1023500 0.505 rs134887 chr22:42674239 A/G cg04733989 chr22:42467013 NAGA 0.65 9.88 0.52 8.45e-20 Schizophrenia; CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -6.57 -0.37 2.71e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2295499 0.643 rs4690086 chr4:2698524 G/A cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.2 -0.3 3.94e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs7584330 0.518 rs78856668 chr2:238438055 A/C cg14458575 chr2:238380390 NA 0.72 6.8 0.39 7.06e-11 Prostate cancer; CESC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg14403583 chr14:105418241 AHNAK2 -0.59 -8.26 -0.45 7.03e-15 Rheumatoid arthritis; CESC trans rs11098499 0.820 rs6534140 chr4:120455311 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.47e-19 Corneal astigmatism; CESC cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.49 6.21 0.36 1.99e-9 Tonsillectomy; CESC cis rs2200578 1.000 rs72961173 chr2:99886868 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.5 5.6 0.33 5.23e-8 IgG glycosylation; CESC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -12.99 -0.62 3.48e-30 Developmental language disorder (linguistic errors); CESC cis rs1348850 0.872 rs10165785 chr2:178293295 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.77 10.87 0.56 5.44e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4523957 0.583 rs2984943 chr17:2030135 T/C cg16513277 chr17:2031491 SMG6 -0.79 -11.71 -0.58 8.09e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06370812 chr3:195501042 MUC4 0.47 6.72 0.38 1.11e-10 Fibrinogen levels; CESC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.62 0.38 2.01e-10 Prudent dietary pattern; CESC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.58 -0.37 2.43e-10 Life satisfaction; CESC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg24110177 chr3:50126178 RBM5 0.53 7.25 0.41 4.7e-12 Intelligence (multi-trait analysis); CESC cis rs1878931 0.624 rs28089 chr16:3446937 G/A cg22508957 chr16:3507546 NAT15 0.47 5.99 0.35 6.79e-9 Body mass index (adult); CESC cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg20607287 chr7:12443886 VWDE -0.75 -8.83 -0.48 1.51e-16 Coronary artery disease; CESC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.45 5.82 0.34 1.69e-8 Lymphocyte counts; CESC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg23590916 chr17:43697445 MGC57346 -0.57 -6.07 -0.35 4.43e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9596863 0.950 rs9563182 chr13:54395310 T/C ch.13.53330881F chr13:54432880 NA 0.66 5.36 0.31 1.84e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs3793917 0.894 rs36212731 chr10:124214976 G/T cg24884230 chr10:124216658 ARMS2 0.3 5.08 0.3 7.19e-7 Age-related macular degeneration; CESC cis rs1670533 1.000 rs6852155 chr4:1067638 T/G cg27284194 chr4:1044797 NA 0.48 6.09 0.35 3.98e-9 Recombination rate (females); CESC cis rs72627509 0.680 rs66790703 chr4:57773908 G/A cg26694713 chr4:57773883 REST 0.58 5.73 0.33 2.7e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs208520 0.690 rs207112 chr6:66792092 C/T cg07460842 chr6:66804631 NA -1.0 -13.33 -0.63 2.21e-31 Exhaled nitric oxide output; CESC cis rs3772130 0.545 rs7340674 chr3:121574215 T/C cg20356878 chr3:121714668 ILDR1 0.44 6.4 0.37 6.92e-10 Cognitive performance; CESC cis rs4595586 0.525 rs17464772 chr12:39247777 G/A cg26384229 chr12:38710491 ALG10B 0.68 10.17 0.53 9.91e-21 Morning vs. evening chronotype; CESC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.16 0.81 2.75e-62 Prudent dietary pattern; CESC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25704207 chr3:50649454 CISH -0.4 -6.1 -0.35 3.84e-9 Gambling; CESC cis rs950776 0.518 rs12906951 chr15:78825562 C/T cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg24642844 chr7:1081250 C7orf50 -0.63 -8.17 -0.45 1.29e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7116495 0.609 rs6592447 chr11:71641093 A/T cg18441811 chr11:71824068 C11orf51 -0.73 -5.11 -0.3 6.22e-7 Severe influenza A (H1N1) infection; CESC cis rs9682041 0.696 rs13067560 chr3:170094190 G/A cg11886554 chr3:170076028 SKIL 0.7 6.5 0.37 3.93e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.1 0.53 1.62e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg03467027 chr4:99064603 C4orf37 0.48 6.0 0.35 6.56e-9 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg05313129 chr8:58192883 C8orf71 -0.48 -5.18 -0.3 4.41e-7 Developmental language disorder (linguistic errors); CESC trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21582582 chr3:182698605 DCUN1D1 -0.44 -6.01 -0.35 6.18e-9 Intelligence (multi-trait analysis); CESC cis rs1788820 0.917 rs1788819 chr18:21100504 G/A cg14672496 chr18:21087552 C18orf8 0.53 7.19 0.4 6.58e-12 Body mass index; CESC cis rs9815354 0.761 rs12186051 chr3:41836919 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs1728785 0.818 rs12926059 chr16:68569459 T/C cg02972257 chr16:68554789 NA -0.55 -6.36 -0.36 8.6e-10 Ulcerative colitis; CESC cis rs796364 0.806 rs34510964 chr2:201010676 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -6.43 -0.37 5.87e-10 Schizophrenia; CESC cis rs7818688 0.585 rs2599714 chr8:96052050 A/G cg16049864 chr8:95962084 TP53INP1 -0.49 -5.59 -0.32 5.69e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs12144309 0.554 rs2476599 chr1:114363459 G/A cg13572289 chr1:114447746 DCLRE1B;AP4B1 0.45 5.24 0.31 3.23e-7 Coronary artery disease; CESC cis rs2243480 0.901 rs73142137 chr7:65343442 A/T cg13147721 chr7:65941812 NA -0.9 -8.76 -0.47 2.35e-16 Diabetic kidney disease; CESC trans rs11601239 0.585 rs685374 chr11:105580112 T/C cg15315312 chr2:176867285 KIAA1715 -0.46 -6.17 -0.35 2.59e-9 Refractive error; CESC cis rs2506889 0.553 rs17035189 chr1:10597024 A/G cg17425144 chr1:10567563 PEX14 0.36 5.68 0.33 3.59e-8 Breast cancer; CESC cis rs921968 0.612 rs573555 chr2:219348888 A/C cg02176678 chr2:219576539 TTLL4 0.39 6.77 0.38 8.06e-11 Mean corpuscular hemoglobin concentration; CESC cis rs796364 0.577 rs7574287 chr2:200680999 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.55 5.06 0.3 7.93e-7 Schizophrenia; CESC trans rs7395662 0.548 rs4882000 chr11:48546496 A/G cg00717180 chr2:96193071 NA -0.44 -6.06 -0.35 4.58e-9 HDL cholesterol; CESC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -5.21 -0.3 3.78e-7 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg26314531 chr2:26401878 FAM59B -0.85 -9.21 -0.49 1.07e-17 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg07507251 chr3:52567010 NT5DC2 0.4 6.96 0.39 2.7e-11 Bipolar disorder; CESC trans rs1829883 0.733 rs2968352 chr5:98724991 G/T cg23861655 chr4:57411219 NA 0.38 6.13 0.35 3.13e-9 Hemostatic factors and hematological phenotypes; CESC cis rs35146811 0.586 rs6964754 chr7:99589404 G/A cg22531904 chr7:99595276 NA -0.39 -5.15 -0.3 5.12e-7 Coronary artery disease; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg08829281 chr12:133264318 PXMP2;POLE -0.47 -6.74 -0.38 9.68e-11 Prostate cancer (SNP x SNP interaction); CESC trans rs459571 0.959 rs378740 chr9:136890876 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.6 -7.58 -0.42 5.64e-13 Platelet distribution width; CESC cis rs116095464 0.558 rs10068203 chr5:206618 C/T cg22496380 chr5:211416 CCDC127 -0.95 -10.05 -0.53 2.34e-20 Breast cancer; CESC cis rs2204008 0.744 rs11181635 chr12:38378420 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.88 0.56 4.92e-23 Bladder cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03433549 chr12:56498817 PA2G4 -0.44 -6.32 -0.36 1.08e-9 Gambling; CESC cis rs1048238 0.506 rs848195 chr1:16286522 A/G cg21385522 chr1:16154831 NA -0.48 -6.2 -0.36 2.21e-9 Systolic blood pressure; CESC cis rs459571 0.804 rs448918 chr9:136885979 G/A cg13789015 chr9:136890014 NCRNA00094 0.56 7.88 0.44 8.33e-14 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03923838 chr6:132834330 STX7 0.56 6.41 0.37 6.51e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.58 0.47 7.92e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4604732 0.631 rs74154672 chr1:247625625 C/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2204008 0.837 rs11168334 chr12:37961768 A/G cg13010199 chr12:38710504 ALG10B 0.52 6.59 0.38 2.36e-10 Bladder cancer; CESC cis rs3820928 1.000 rs2396433 chr2:227772502 A/G cg05526886 chr2:227700861 RHBDD1 -0.42 -5.54 -0.32 7.19e-8 Pulmonary function; CESC cis rs4523957 0.579 rs4790883 chr17:2087605 T/C cg16513277 chr17:2031491 SMG6 -0.64 -8.87 -0.48 1.11e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs17639215 0.550 rs4851003 chr2:102909277 T/C cg09003973 chr2:102972529 NA 0.49 5.06 0.3 7.93e-7 Serum protein levels (sST2); CESC cis rs5758659 0.716 rs5758661 chr22:42624445 A/C cg00645731 chr22:42541494 CYP2D7P1 -0.3 -5.07 -0.3 7.62e-7 Cognitive function; CESC cis rs8072100 0.575 rs1221385 chr17:45527574 T/G cg08085267 chr17:45401833 C17orf57 -0.49 -6.21 -0.36 2.02e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs727563 0.636 rs2187795 chr22:42092225 C/A cg06634786 chr22:41940651 POLR3H 0.65 6.47 0.37 4.73e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg15605315 chr1:45957053 TESK2 0.42 5.3 0.31 2.42e-7 High light scatter reticulocyte count; CESC cis rs6570726 0.846 rs397311 chr6:145806701 C/T cg23711669 chr6:146136114 FBXO30 -0.86 -12.94 -0.62 5.09e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs10751667 0.666 rs4074235 chr11:977511 C/G cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.48e-7 Alzheimer's disease (late onset); CESC cis rs4594175 0.886 rs11157801 chr14:51622918 C/T cg23942311 chr14:51606299 NA 0.39 6.05 0.35 4.9e-9 Cancer; CESC cis rs61931739 0.500 rs11053211 chr12:34464334 T/C cg23762105 chr12:34175262 ALG10 -0.4 -5.12 -0.3 5.81e-7 Morning vs. evening chronotype; CESC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg23172400 chr8:95962367 TP53INP1 -0.5 -11.15 -0.57 6.23e-24 Type 2 diabetes; CESC cis rs12545109 0.765 rs2055985 chr8:57410821 T/A cg09654669 chr8:57350985 NA -0.47 -6.5 -0.37 4.05e-10 Obesity-related traits; CESC cis rs7680126 0.633 rs28378345 chr4:10209897 A/G cg11266682 chr4:10021025 SLC2A9 -0.39 -5.15 -0.3 5.12e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs11864453 0.647 rs8043606 chr16:72135319 T/C cg01557791 chr16:72042693 DHODH -0.43 -5.63 -0.33 4.58e-8 Fibrinogen levels; CESC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg06873352 chr17:61820015 STRADA 0.47 6.86 0.39 4.85e-11 Height; CESC cis rs7605827 0.930 rs11902167 chr2:15494391 C/T cg19274914 chr2:15703543 NA 0.31 5.62 0.33 4.89e-8 Educational attainment (years of education); CESC cis rs2694528 0.764 rs112511311 chr5:59872002 G/A cg11474532 chr5:59995715 DEPDC1B 0.91 6.37 0.36 8.39e-10 Parkinson's disease; CESC cis rs4820539 0.966 rs2301554 chr22:23484254 A/C cg14186256 chr22:23484241 RTDR1 0.88 16.24 0.71 1.2e-41 Bone mineral density; CESC cis rs7772486 0.806 rs7740785 chr6:146171299 C/A cg05347473 chr6:146136440 FBXO30 0.51 6.76 0.38 8.64e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.606 rs6852813 chr4:99084671 G/A cg05340658 chr4:99064831 C4orf37 0.65 9.03 0.49 3.66e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.692 rs34272342 chr15:77012276 A/C cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC cis rs1153858 1.000 rs9783731 chr15:45642884 C/T cg21132104 chr15:45694354 SPATA5L1 -0.8 -10.8 -0.55 9.27e-23 Homoarginine levels; CESC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg00149659 chr3:10157352 C3orf10 0.69 8.09 0.45 2.13e-14 Alzheimer's disease; CESC cis rs6088590 0.965 rs910869 chr20:33292777 C/T cg08999081 chr20:33150536 PIGU 0.59 8.79 0.48 1.88e-16 Coronary artery disease; CESC cis rs34638657 0.872 rs2967326 chr16:82188246 A/G cg09439754 chr16:82129088 HSD17B2 -0.35 -5.24 -0.31 3.26e-7 Lung adenocarcinoma; CESC cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg11764359 chr7:65958608 NA 0.96 15.37 0.69 1.5e-38 Aortic root size; CESC cis rs3820928 0.874 rs56324594 chr2:227868854 C/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.28 -0.31 2.66e-7 Pulmonary function; CESC cis rs763014 0.931 rs2071982 chr16:630405 T/G cg07343612 chr16:622815 PIGQ -0.58 -8.47 -0.46 1.72e-15 Height; CESC cis rs17209837 0.607 rs2888611 chr7:87103670 C/G cg00919237 chr7:87102261 ABCB4 0.5 6.5 0.37 3.98e-10 Gallbladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08386897 chr10:134073820 STK32C -0.55 -6.54 -0.37 3.18e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.559 rs5758428 chr22:42106216 G/A cg06634786 chr22:41940651 POLR3H 0.67 6.72 0.38 1.12e-10 Vitiligo; CESC cis rs73058052 0.935 rs3745473 chr19:50086626 T/C cg09250473 chr19:50168907 IRF3;BCL2L12 0.58 5.49 0.32 9.49e-8 Fibrinogen levels; CESC cis rs7107174 0.892 rs10899487 chr11:78085474 G/A cg02023728 chr11:77925099 USP35 0.47 6.23 0.36 1.82e-9 Testicular germ cell tumor; CESC cis rs6500395 1.000 rs11859909 chr16:48668441 T/C cg04672837 chr16:48644449 N4BP1 0.51 6.43 0.37 6.06e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1018836 0.892 rs5005585 chr8:91581975 A/G cg16814680 chr8:91681699 NA -0.61 -8.57 -0.47 8.45e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs748404 0.697 rs567357 chr15:43571390 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.51 8.03 0.44 3.27e-14 Lung cancer; CESC cis rs6500395 1.000 rs1420701 chr16:48730873 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.41 -0.37 6.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21830480 chr12:72057690 THAP2;ZFC3H1 -0.48 -6.24 -0.36 1.72e-9 Asthma; CESC cis rs28647808 1.000 rs28756699 chr9:136273527 G/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs6570726 0.791 rs952406 chr6:145925616 C/A cg23711669 chr6:146136114 FBXO30 0.85 12.48 0.61 2.03e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg20573242 chr4:122745356 CCNA2 0.62 7.44 0.42 1.41e-12 Type 2 diabetes; CESC cis rs8028182 0.636 rs7163907 chr15:75845097 T/C cg20655648 chr15:75932815 IMP3 0.48 5.93 0.34 9.58e-9 Sudden cardiac arrest; CESC cis rs3213545 0.659 rs2259690 chr12:121457914 T/G cg02403541 chr12:121454288 C12orf43 0.74 10.68 0.55 2.25e-22 Subjective well-being;Cardiovascular disease risk factors; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg02732671 chr3:134204521 CEP63;ANAPC13 0.48 6.16 0.35 2.71e-9 Thyroid stimulating hormone; CESC cis rs6756513 0.501 rs7581977 chr2:70174054 C/T cg02498382 chr2:70120550 SNRNP27 0.29 5.06 0.3 7.69e-7 Breast cancer;Platelet count; CESC cis rs6565681 0.883 rs4523980 chr17:78347664 A/G cg15383979 chr17:78362278 RNF213;LOC100294362 -0.75 -8.4 -0.46 2.75e-15 Moyamoya disease; CESC cis rs11048434 0.736 rs7957321 chr12:9120154 C/T cg23795048 chr12:9217529 LOC144571 0.35 5.26 0.31 2.94e-7 Sjögren's syndrome; CESC cis rs2952156 1.000 rs2934971 chr17:37854507 G/T cg19468946 chr17:37922297 IKZF3 -0.42 -5.17 -0.3 4.55e-7 Asthma; CESC cis rs2797160 0.837 rs1739364 chr6:126022383 A/G cg05901451 chr6:126070800 HEY2 -0.45 -6.63 -0.38 1.89e-10 Endometrial cancer; CESC cis rs4908768 0.501 rs1922983 chr1:8531326 A/G cg00120948 chr1:8484417 RERE -0.33 -5.1 -0.3 6.59e-7 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CESC cis rs4699052 0.590 rs4698892 chr4:104261271 C/G cg16532752 chr4:104119610 CENPE -0.39 -5.52 -0.32 8.23e-8 Testicular germ cell tumor; CESC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs2243480 1.000 rs6959002 chr7:65650496 A/G cg13147721 chr7:65941812 NA 0.97 9.16 0.49 1.47e-17 Diabetic kidney disease; CESC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg12564285 chr5:131593104 PDLIM4 -0.41 -6.26 -0.36 1.5e-9 Breast cancer; CESC cis rs12995491 0.933 rs12995212 chr2:88527184 C/T cg07952391 chr2:88470173 THNSL2 -0.53 -7.81 -0.43 1.32e-13 Response to metformin (IC50); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19789755 chr7:56950153 NA -0.43 -6.02 -0.35 5.68e-9 Systemic lupus erythematosus; CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg08968635 chr6:28129556 ZNF389 0.42 5.73 0.33 2.7e-8 Depression; CESC cis rs854765 0.547 rs2955380 chr17:17944349 A/G cg04398451 chr17:18023971 MYO15A 0.73 10.55 0.54 5.95e-22 Total body bone mineral density; CESC cis rs7639513 0.767 rs3806661 chr3:12705855 A/G cg23032965 chr3:12705835 RAF1 0.76 10.79 0.55 9.63e-23 Itch intensity from mosquito bite; CESC cis rs1538970 0.962 rs9429072 chr1:45810091 C/T cg05343316 chr1:45956843 TESK2 -0.81 -11.5 -0.58 4.2e-25 Platelet count; CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg06873352 chr17:61820015 STRADA -0.67 -11.69 -0.58 9.45e-26 Prudent dietary pattern; CESC cis rs35740288 0.539 rs11634553 chr15:86336611 G/A cg20737812 chr15:86336631 KLHL25 -0.42 -5.28 -0.31 2.71e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg02038168 chr22:39784481 NA -0.64 -7.52 -0.42 8.37e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs847577 0.674 rs7790479 chr7:97713101 C/G cg21770322 chr7:97807741 LMTK2 0.64 10.58 0.55 4.59e-22 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01501135 chr17:16342235 NCRNA00188;SNORD49B;SNORD49A 0.59 6.97 0.39 2.58e-11 Gut microbiome composition (summer); CESC cis rs2651899 0.934 rs1627080 chr1:3081309 T/C cg07622451 chr1:3079886 PRDM16 0.31 5.36 0.31 1.82e-7 Migraine; CESC cis rs7918232 0.567 rs11015463 chr10:27319258 A/G cg14240646 chr10:27532245 ACBD5 -0.48 -5.21 -0.3 3.78e-7 Breast cancer; CESC cis rs2070997 0.607 rs2183224 chr9:133665081 G/A cg11464064 chr9:133710261 ABL1 0.49 5.61 0.33 5.08e-8 Response to amphetamines; CESC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg17372223 chr3:52568218 NT5DC2 -0.43 -6.51 -0.37 3.81e-10 Bipolar disorder; CESC cis rs34779708 0.931 rs59418206 chr10:35331624 G/A cg04310649 chr10:35416472 CREM -0.5 -5.96 -0.34 7.83e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02839306 chr19:33165564 ANKRD27;RGS9BP 0.61 6.51 0.37 3.72e-10 Gut microbiome composition (summer); CESC cis rs113835537 0.529 rs17065 chr11:66277035 G/A cg24851651 chr11:66362959 CCS 0.49 5.86 0.34 1.34e-8 Airway imaging phenotypes; CESC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 5.89 0.34 1.2e-8 Personality dimensions; CESC cis rs4851870 0.874 rs59912414 chr2:106449674 C/A cg16077055 chr2:106428750 NCK2 -0.39 -5.05 -0.3 8.15e-7 Addiction; CESC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg08888203 chr3:10149979 C3orf24 0.48 6.1 0.35 3.84e-9 Alzheimer's disease; CESC cis rs1816752 1.000 rs9511265 chr13:25012359 T/C cg02811702 chr13:24901961 NA 0.39 5.7 0.33 3.2e-8 Obesity-related traits; CESC cis rs4523957 0.928 rs216223 chr17:2155948 C/T cg16513277 chr17:2031491 SMG6 0.6 8.23 0.45 8.75e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2839186 0.605 rs2839174 chr21:47676934 T/C cg10351095 chr21:47802916 PCNT -0.49 -6.57 -0.37 2.58e-10 Testicular germ cell tumor; CESC cis rs644799 0.542 rs10831418 chr11:95468828 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.66 9.2 0.49 1.12e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4662945 0.603 rs13002385 chr2:130276865 T/C cg05962382 chr2:130345044 NA -0.5 -7.13 -0.4 9.81e-12 Response to cytidine analogues (gemcitabine); CESC cis rs12681288 0.676 rs2701923 chr8:994605 A/G cg15309053 chr8:964076 NA 0.4 6.81 0.39 6.66e-11 Schizophrenia; CESC cis rs6426558 0.537 rs6662583 chr1:227383889 A/G cg10327440 chr1:227177885 CDC42BPA -0.5 -6.41 -0.37 6.59e-10 Neutrophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24641901 chr11:93212232 C11orf75 0.51 6.83 0.39 5.93e-11 Fibrinogen levels; CESC cis rs9911578 0.835 rs9788975 chr17:56460800 G/A cg12560992 chr17:57184187 TRIM37 -0.85 -13.78 -0.65 6.11e-33 Intelligence (multi-trait analysis); CESC cis rs9488822 0.676 rs12196579 chr6:116351724 G/T cg15226275 chr6:116381976 FRK 0.26 6.48 0.37 4.43e-10 Cholesterol, total;LDL cholesterol; CESC cis rs3812762 0.871 rs3862352 chr11:8818020 C/T cg03980550 chr11:8754370 ST5 -0.39 -5.49 -0.32 9.43e-8 Hypospadias; CESC cis rs2806561 0.765 rs643492 chr1:23501354 C/T cg12483005 chr1:23474871 LUZP1 -0.38 -6.02 -0.35 5.88e-9 Height; CESC cis rs72829446 0.530 rs2302761 chr17:7358520 C/T cg02795151 chr17:7402630 POLR2A 0.51 5.35 0.31 1.87e-7 Androgen levels; CESC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg22800045 chr5:56110881 MAP3K1 0.41 5.04 0.3 8.55e-7 Breast cancer;Breast cancer (early onset); CESC cis rs9611565 0.921 rs5758297 chr22:41720697 A/G cg06481639 chr22:41940642 POLR3H -0.45 -5.36 -0.31 1.83e-7 Vitiligo; CESC cis rs9868809 0.881 rs2310996 chr3:48671834 T/C cg07636037 chr3:49044803 WDR6 -0.67 -6.07 -0.35 4.36e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.69 0.38 1.35e-10 Bipolar disorder; CESC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg24060327 chr5:131705240 SLC22A5 0.78 11.17 0.57 5.53e-24 Breast cancer; CESC cis rs12586317 0.545 rs58342373 chr14:35395269 T/C cg16230307 chr14:35515116 FAM177A1 0.81 8.51 0.46 1.27e-15 Psoriasis; CESC cis rs74181299 1.000 rs74181299 chr2:65283972 T/C cg05010058 chr2:65284262 CEP68 0.34 6.02 0.35 5.77e-9 Pulse pressure; CESC cis rs1790761 0.587 rs4930430 chr11:67294198 A/G cg24690094 chr11:67383802 NA 0.34 5.97 0.34 7.65e-9 Mean corpuscular volume; CESC cis rs367615 0.918 rs17161889 chr5:108855251 A/G cg17395555 chr5:108820864 NA -0.54 -8.25 -0.45 7.51e-15 Colorectal cancer (SNP x SNP interaction); CESC cis rs977987 0.806 rs766521 chr16:75424154 A/G cg03315344 chr16:75512273 CHST6 -0.41 -6.05 -0.35 4.96e-9 Dupuytren's disease; CESC cis rs12540874 0.529 rs732215 chr7:50544063 A/C cg18232548 chr7:50535776 DDC -0.43 -6.15 -0.35 2.82e-9 Systemic sclerosis; CESC cis rs11931598 1.000 rs11931598 chr4:7047102 A/G cg26116260 chr4:7069785 GRPEL1 0.38 5.65 0.33 4.21e-8 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11674231 chr7:5821297 RNF216 -0.5 -7.06 -0.4 1.46e-11 Ulcerative colitis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23171573 chr15:41099257 ZFYVE19;DNAJC17 -0.47 -6.0 -0.35 6.37e-9 Ulcerative colitis; CESC cis rs372883 0.648 rs4817279 chr21:30638285 T/C cg24692254 chr21:30365293 RNF160 -0.54 -6.93 -0.39 3.18e-11 Pancreatic cancer; CESC cis rs989128 0.600 rs916978 chr17:48630452 T/C cg24438145 chr17:48624694 SPATA20 0.45 5.31 0.31 2.36e-7 Type 2 diabetes; CESC cis rs34779708 0.766 rs16935949 chr10:35551815 T/C cg04310649 chr10:35416472 CREM -0.47 -5.31 -0.31 2.33e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs7631605 0.905 rs7615363 chr3:37006262 A/G cg22985146 chr3:37219077 LRRFIP2 -0.34 -5.41 -0.32 1.39e-7 Cerebrospinal P-tau181p levels; CESC cis rs1707322 1.000 rs34444543 chr1:46358862 G/A cg06784218 chr1:46089804 CCDC17 0.3 5.1 0.3 6.38e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35110281 0.506 rs13051661 chr21:45111518 A/T cg04455712 chr21:45112962 RRP1B 0.51 8.0 0.44 3.9e-14 Mean corpuscular volume; CESC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg18876405 chr7:65276391 NA 0.69 9.72 0.51 2.78e-19 Calcium levels; CESC cis rs208520 0.690 rs7739253 chr6:66861052 A/G cg07460842 chr6:66804631 NA -1.0 -13.46 -0.64 8.08e-32 Exhaled nitric oxide output; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg08064573 chr19:3700773 PIP5K1C -0.51 -6.48 -0.37 4.56e-10 Height; CESC cis rs6582630 0.555 rs10880613 chr12:38509553 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.68 0.55 2.17e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.33 -0.31 2.16e-7 Lung cancer; CESC cis rs6089584 0.566 rs6061963 chr20:60607480 C/G cg23463467 chr20:60627584 TAF4 0.35 5.06 0.3 7.8e-7 Body mass index; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg16650099 chr1:114471848 HIPK1 -0.45 -6.13 -0.35 3.24e-9 Height; CESC cis rs9911578 0.967 rs4932693 chr17:57110327 T/C cg05425664 chr17:57184151 TRIM37 0.52 7.19 0.4 6.63e-12 Intelligence (multi-trait analysis); CESC cis rs7589728 0.925 rs80065975 chr2:88502758 G/A cg04511125 chr2:88470314 THNSL2 0.57 5.47 0.32 1.06e-7 Plasma clusterin levels; CESC cis rs6800768 0.633 rs59461522 chr3:24100377 G/A cg10674438 chr3:24145617 LOC152024 -0.42 -5.61 -0.33 4.97e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg18357645 chr12:58087776 OS9 -0.42 -5.84 -0.34 1.52e-8 Multiple sclerosis; CESC cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1005224 0.895 rs6574252 chr14:76141834 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.42 -5.75 -0.33 2.5e-8 Large artery stroke; CESC cis rs3820928 0.935 rs113195824 chr2:227769139 A/G cg11843606 chr2:227700838 RHBDD1 -0.43 -5.7 -0.33 3.11e-8 Pulmonary function; CESC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg23590916 chr17:43697445 MGC57346 -0.6 -6.27 -0.36 1.47e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs561341 1.000 rs8069199 chr17:30281845 A/G cg00745463 chr17:30367425 LRRC37B -0.7 -7.02 -0.4 1.85e-11 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9488822 0.676 rs11757115 chr6:116362619 C/T cg15226275 chr6:116381976 FRK 0.25 6.41 0.37 6.76e-10 Cholesterol, total;LDL cholesterol; CESC cis rs3767633 0.925 rs1394070 chr1:161814020 T/G cg09175582 chr1:161736000 ATF6 0.86 6.85 0.39 5.21e-11 IgG glycosylation; CESC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg20790798 chr5:1857306 NA -0.39 -5.32 -0.31 2.26e-7 Cardiovascular disease risk factors; CESC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg06481639 chr22:41940642 POLR3H -0.64 -6.6 -0.38 2.21e-10 Vitiligo; CESC cis rs13191362 0.507 rs6936804 chr6:163069424 A/T cg06582575 chr6:163149167 PACRG;PARK2 -0.53 -6.22 -0.36 1.98e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7692995 1.000 rs10516315 chr4:18016877 A/G cg08925142 chr4:18023851 LCORL -0.44 -5.07 -0.3 7.47e-7 Height; CESC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg07414643 chr4:187882934 NA 0.54 7.39 0.41 1.87e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs690037 0.809 rs690023 chr3:16386354 C/T cg23474789 chr3:16306055 DPH3;OXNAD1 -0.4 -5.4 -0.32 1.45e-7 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); CESC cis rs4566357 0.539 rs10933164 chr2:227860671 A/G cg11843606 chr2:227700838 RHBDD1 -0.73 -9.09 -0.49 2.31e-17 Coronary artery disease; CESC cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg21395723 chr22:39101663 GTPBP1 0.43 5.28 0.31 2.75e-7 Menopause (age at onset); CESC cis rs6540556 0.723 rs6752 chr1:209908100 G/A cg23920097 chr1:209922102 NA -0.39 -5.07 -0.3 7.55e-7 Red blood cell count; CESC cis rs7555523 0.778 rs2790052 chr1:165738463 G/C cg24409356 chr1:165738333 TMCO1 0.97 8.63 0.47 5.95e-16 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.93 0.34 9.24e-9 Tonsillectomy; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06697439 chr19:59031463 ZBTB45 -0.46 -6.43 -0.37 5.76e-10 Asthma; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00911289 chr3:128840257 RAB43 -0.54 -7.15 -0.4 8.29e-12 Asthma; CESC cis rs6460942 0.591 rs4721078 chr7:12334657 T/A cg06484146 chr7:12443880 VWDE -0.66 -7.27 -0.41 4.01e-12 Coronary artery disease; CESC cis rs9325144 0.510 rs7952795 chr12:38720686 C/T cg26384229 chr12:38710491 ALG10B 0.57 7.96 0.44 4.99e-14 Morning vs. evening chronotype; CESC cis rs763014 0.833 rs916415 chr16:632115 G/A cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC cis rs11098499 0.738 rs28687057 chr4:120280812 A/G cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs1348850 0.597 rs13014417 chr2:178417835 T/G cg23306229 chr2:178417860 TTC30B 0.89 9.75 0.51 2.11e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4746818 1.000 rs10733850 chr10:70959617 C/T cg04149295 chr10:70884716 VPS26A 0.58 5.07 0.3 7.44e-7 Left atrial antero-posterior diameter; CESC cis rs73019876 0.680 rs807951 chr19:22120363 A/G cg11619707 chr19:22235551 ZNF257 0.3 5.71 0.33 2.96e-8 Testicular germ cell tumor; CESC cis rs748404 0.697 rs555001 chr15:43545728 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.87 0.44 8.86e-14 Lung cancer; CESC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg27535305 chr1:53392650 SCP2 0.35 6.08 0.35 4.18e-9 Monocyte count; CESC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs1018836 0.923 rs13262354 chr8:91635731 G/A cg16814680 chr8:91681699 NA -0.78 -11.16 -0.57 5.82e-24 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9611565 0.573 rs9306355 chr22:42111896 A/T cg03806693 chr22:41940476 POLR3H 0.76 9.27 0.49 6.64e-18 Vitiligo; CESC cis rs7772486 0.875 rs7739371 chr6:146424353 C/G cg23711669 chr6:146136114 FBXO30 0.85 12.45 0.61 2.6e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2295499 0.754 rs16843291 chr4:2728092 C/G cg08330972 chr4:2403930 ZFYVE28 -0.31 -5.06 -0.3 7.76e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs473651 0.506 rs561264 chr2:239329979 G/T cg18131467 chr2:239335373 ASB1 0.89 11.42 0.57 7.98e-25 Multiple system atrophy; CESC cis rs7264396 0.690 rs2425183 chr20:34450621 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.57 -0.58 2.57e-25 Total cholesterol levels; CESC cis rs6964587 0.967 rs12531966 chr7:91765840 A/G cg17063962 chr7:91808500 NA 0.55 7.5 0.42 9.9e-13 Breast cancer; CESC cis rs2820292 0.619 rs11576508 chr1:201824390 G/A cg06775570 chr1:201857621 SHISA4 -0.31 -5.04 -0.3 8.65e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg18305652 chr10:134549665 INPP5A 0.49 7.12 0.4 1.01e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2075371 0.829 rs11770521 chr7:133936251 A/C cg20476274 chr7:133979776 SLC35B4 0.61 8.74 0.47 2.63e-16 Mean platelet volume; CESC cis rs7100689 0.646 rs4265545 chr10:82119271 G/T cg00277334 chr10:82204260 NA -0.59 -7.86 -0.43 9.6e-14 Post bronchodilator FEV1; CESC cis rs10883723 0.773 rs11191313 chr10:104278618 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.59 7.31 0.41 3.18e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs7020830 0.858 rs13293465 chr9:37127678 C/T cg14294708 chr9:37120828 ZCCHC7 1.24 23.87 0.83 5.52e-68 Schizophrenia; CESC trans rs6089829 0.855 rs6090205 chr20:61665269 A/G cg23505145 chr19:12996616 KLF1 0.52 6.8 0.39 6.85e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs11190604 1.000 rs2489037 chr10:102319918 A/G cg07080220 chr10:102295463 HIF1AN -0.63 -5.73 -0.33 2.74e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs2797160 1.000 rs2747723 chr6:126010790 C/T cg05901451 chr6:126070800 HEY2 0.47 6.85 0.39 5.01e-11 Endometrial cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18697049 chr6:111136368 CDK19 0.45 6.03 0.35 5.54e-9 Systemic lupus erythematosus; CESC cis rs1707322 0.682 rs12041197 chr1:46104464 T/C cg05343316 chr1:45956843 TESK2 0.51 6.35 0.36 9.44e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3820068 0.581 rs34453754 chr1:15993208 G/C cg18133145 chr1:16060689 PLEKHM2 -0.43 -5.48 -0.32 1.01e-7 Systolic blood pressure; CESC cis rs1670533 0.872 rs935969 chr4:1062588 A/G cg27284194 chr4:1044797 NA 0.48 6.03 0.35 5.37e-9 Recombination rate (females); CESC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg08888203 chr3:10149979 C3orf24 0.47 5.96 0.34 7.94e-9 Alzheimer's disease; CESC trans rs9951602 0.512 rs8089108 chr18:76651361 C/T cg02800362 chr5:177631904 HNRNPAB 0.66 8.64 0.47 5.41e-16 Obesity-related traits; CESC cis rs1670533 0.685 rs56019586 chr4:1059842 C/G cg04106633 chr4:1044584 NA 0.42 5.3 0.31 2.49e-7 Recombination rate (females); CESC cis rs1018836 0.847 rs2285231 chr8:91545387 G/T cg16814680 chr8:91681699 NA -0.7 -10.31 -0.53 3.59e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg27170947 chr2:26402098 FAM59B -0.58 -6.91 -0.39 3.69e-11 Gut microbiome composition (summer); CESC cis rs113835537 0.529 rs17147644 chr11:66256660 C/T cg24851651 chr11:66362959 CCS 0.47 5.77 0.33 2.16e-8 Airway imaging phenotypes; CESC cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg26597838 chr10:835615 NA 0.7 6.53 0.37 3.31e-10 Eosinophil percentage of granulocytes; CESC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg12667521 chr19:29218732 NA 0.48 6.4 0.37 6.97e-10 Methadone dose in opioid dependence; CESC cis rs1348850 0.519 rs13034781 chr2:178523550 C/A cg23306229 chr2:178417860 TTC30B 0.46 5.38 0.31 1.67e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg20203395 chr5:56204925 C5orf35 0.5 5.83 0.34 1.65e-8 Initial pursuit acceleration; CESC cis rs7577696 0.597 rs7556942 chr2:32295694 G/A cg02381751 chr2:32503542 YIPF4 -0.42 -5.05 -0.3 8.32e-7 Inflammatory biomarkers; CESC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg19723775 chr5:179050963 HNRNPH1 -0.4 -5.33 -0.31 2.09e-7 Lung cancer; CESC cis rs559928 0.692 rs876064 chr11:64037033 G/A cg18225595 chr11:63971243 STIP1 0.61 5.2 0.3 4.04e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg02951883 chr7:2050386 MAD1L1 -0.49 -6.39 -0.37 7.45e-10 Bipolar disorder and schizophrenia; CESC cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg16278512 chr7:12443529 VWDE -0.45 -5.16 -0.3 4.96e-7 Coronary artery disease; CESC cis rs28647808 1.000 rs6597629 chr9:136270841 A/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27405321 chr20:34359917 PHF20 -0.62 -7.79 -0.43 1.52e-13 Gut microbiome composition (summer); CESC cis rs11640734 0.609 rs11647746 chr16:89806343 C/A cg00800038 chr16:89945340 TCF25 -0.66 -6.35 -0.36 9.4e-10 Interleukin-17 levels; CESC cis rs2901656 1.000 rs6691993 chr1:172426998 T/G cg03748243 chr1:172413542 C1orf105;PIGC 0.42 6.35 0.36 9.11e-10 Red cell distribution width;Platelet distribution width; CESC cis rs9329289 0.603 rs2458705 chr10:2541377 A/G cg05625103 chr10:2543513 NA 0.44 6.01 0.35 6.03e-9 Age-related hearing impairment; CESC cis rs2072732 0.756 rs77415878 chr1:2954047 C/G cg15211996 chr1:2936768 ACTRT2 0.34 5.78 0.33 2.08e-8 Plateletcrit; CESC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg06221963 chr1:154839813 KCNN3 -0.66 -11.32 -0.57 1.71e-24 Prostate cancer; CESC cis rs3892630 0.824 rs35654350 chr19:33223766 T/C cg13157960 chr19:33183277 NUDT19 0.54 5.09 0.3 6.83e-7 Red blood cell traits; CESC cis rs7714584 1.000 rs11167518 chr5:150258920 C/A cg22134413 chr5:150180641 NA 0.47 5.29 0.31 2.5e-7 Crohn's disease; CESC cis rs6904897 0.563 rs4896117 chr6:135229400 T/C cg24558204 chr6:135376177 HBS1L -0.55 -7.43 -0.42 1.48e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs854765 0.547 rs9894138 chr17:17964345 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.54 -7.0 -0.4 2.06e-11 Total body bone mineral density; CESC cis rs2658782 0.547 rs4753453 chr11:93041174 T/G cg15737290 chr11:93063684 CCDC67 0.5 6.83 0.39 5.83e-11 Pulmonary function decline; CESC cis rs477692 1.000 rs553371 chr10:131413676 T/C cg05714579 chr10:131428358 MGMT 0.45 6.11 0.35 3.5e-9 Response to temozolomide; CESC cis rs1215050 0.765 rs783947 chr4:99012943 T/C cg05340658 chr4:99064831 C4orf37 -0.55 -7.45 -0.42 1.36e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs6062302 0.522 rs2236503 chr20:62224595 G/A cg06363034 chr20:62225388 GMEB2 -0.52 -6.69 -0.38 1.3100000000000001e-10 Glioblastoma; CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg09177884 chr7:1199841 ZFAND2A -0.58 -6.39 -0.37 7.38e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9908102 0.682 rs56338821 chr17:12905125 T/C cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs7618501 1.000 rs9855505 chr3:49792158 T/G cg24308560 chr3:49941425 MST1R 0.5 6.71 0.38 1.15e-10 Intelligence (multi-trait analysis); CESC cis rs7216064 1.000 rs8071463 chr17:65938655 C/T cg07042672 chr17:66097459 LOC651250 0.61 7.32 0.41 2.96e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs854765 0.718 rs12943500 chr17:17790588 C/T cg04398451 chr17:18023971 MYO15A 0.62 8.31 0.45 5.1e-15 Total body bone mineral density; CESC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.53 -0.42 7.92e-13 Gut microbiome composition (summer); CESC cis rs4853525 0.617 rs12998878 chr2:191770894 C/T cg21644426 chr2:191273491 MFSD6 0.46 5.87 0.34 1.31e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; CESC cis rs2370759 1.000 rs76998371 chr10:32631785 A/G cg18270830 chr10:32634957 EPC1 0.71 6.87 0.39 4.58e-11 Sexual dysfunction (female); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20930514 chr14:77499758 NA -0.41 -6.18 -0.35 2.45e-9 Gambling; CESC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.18 0.3 4.4e-7 Colonoscopy-negative controls vs population controls; CESC cis rs151349 1.000 rs151344 chr20:57585301 A/G cg23907860 chr20:57583709 CTSZ -0.41 -6.63 -0.38 1.83e-10 Platelet distribution width; CESC cis rs477692 1.000 rs554792 chr10:131423181 A/G cg05714579 chr10:131428358 MGMT 0.48 6.49 0.37 4.29e-10 Response to temozolomide; CESC cis rs909674 0.514 rs7423 chr22:39781429 C/T cg11247378 chr22:39784982 NA -0.51 -7.92 -0.44 6.61e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27502066 chr17:74380231 SPHK1 0.51 6.11 0.35 3.52e-9 Gut microbiome composition (summer); CESC cis rs9911578 1.000 rs2531734 chr17:56550804 T/C cg12560992 chr17:57184187 TRIM37 -0.92 -15.31 -0.69 2.4e-38 Intelligence (multi-trait analysis); CESC cis rs116095464 0.558 rs10058428 chr5:235608 A/G cg20965017 chr5:231967 SDHA -0.45 -5.1 -0.3 6.61e-7 Breast cancer; CESC cis rs447 1.000 rs7804563 chr7:83777694 G/A cg22846510 chr7:83753280 SEMA3A -0.42 -5.19 -0.3 4.19e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7193541 0.684 rs4888262 chr16:74670458 C/T cg05580060 chr16:74700937 RFWD3 -0.45 -5.71 -0.33 3.06e-8 Multiple myeloma; CESC cis rs9399135 0.967 rs7763836 chr6:135362378 T/C cg22676075 chr6:135203613 NA 0.52 7.31 0.41 3.07e-12 Red blood cell count; CESC cis rs116095464 0.558 rs9687898 chr5:253952 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.28 0.31 2.76e-7 Breast cancer; CESC cis rs938554 0.735 rs12498742 chr4:9944052 A/G cg00071950 chr4:10020882 SLC2A9 -0.46 -5.68 -0.33 3.54e-8 Blood metabolite levels; CESC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg27170947 chr2:26402098 FAM59B -0.84 -10.03 -0.52 2.88e-20 Gut microbiome composition (summer); CESC cis rs10088262 0.629 rs7828192 chr8:124804669 C/T cg02993010 chr8:124780839 FAM91A1 -0.65 -8.13 -0.45 1.69e-14 Pancreatic cancer; CESC cis rs854765 0.520 rs9899355 chr17:17898243 C/T cg04398451 chr17:18023971 MYO15A -0.62 -8.58 -0.47 7.9e-16 Total body bone mineral density; CESC cis rs9837602 0.935 rs4928149 chr3:99685686 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -5.51 -0.32 8.44e-8 Breast cancer; CESC cis rs6951245 0.572 rs73264028 chr7:1045455 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.65 -6.09 -0.35 3.87e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.09 0.6 4.15e-27 Alzheimer's disease; CESC trans rs11098499 0.955 rs6815725 chr4:120158410 C/A cg25214090 chr10:38739885 LOC399744 0.64 8.63 0.47 5.92e-16 Corneal astigmatism; CESC cis rs5498 0.809 rs2228615 chr19:10403368 G/A cg08845333 chr19:10403403 ICAM5 0.4 5.49 0.32 9.2e-8 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC trans rs875971 1.000 rs937495 chr7:65779798 A/G cg26939375 chr7:64535504 NA -0.46 -6.08 -0.35 4.27e-9 Aortic root size; CESC cis rs61776719 0.738 rs7555461 chr1:38444749 T/C cg17077180 chr1:38461687 NA -0.52 -7.78 -0.43 1.66e-13 Coronary artery disease; CESC trans rs1545843 0.564 rs2403206 chr12:84889647 C/A cg03015433 chr16:56623111 MT3 0.33 6.01 0.35 6.09e-9 Major depressive disorder; CESC cis rs6893300 0.524 rs6601073 chr5:179177271 A/G cg14593053 chr5:179126677 CANX -0.54 -7.88 -0.44 8.61e-14 Resting heart rate; CESC cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg13944838 chr5:179740914 GFPT2 -0.61 -8.18 -0.45 1.18e-14 Height; CESC cis rs6484504 0.652 rs485265 chr11:31407788 G/A cg14844989 chr11:31128820 NA 0.36 5.05 0.3 8.33e-7 Red blood cell count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06130365 chr10:135122020 TUBGCP2;ZNF511 0.46 6.08 0.35 4.22e-9 Gut microbiota (bacterial taxa); CESC cis rs11203032 1.000 rs11203032 chr10:90964614 T/G cg16672925 chr10:90967113 CH25H 0.74 7.11 0.4 1.09e-11 Heart failure; CESC cis rs1065852 0.906 rs5751232 chr22:42564304 C/T cg00645731 chr22:42541494 CYP2D7P1 0.6 8.89 0.48 9.89e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs67311347 1.000 rs4973989 chr3:40451543 C/T cg09455208 chr3:40491958 NA 0.53 8.62 0.47 6.29e-16 Renal cell carcinoma; CESC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg20887711 chr4:1340912 KIAA1530 0.62 8.45 0.46 1.94e-15 Longevity; CESC cis rs9640161 0.830 rs3757423 chr7:150067714 A/G cg21361702 chr7:150065534 REPIN1 -0.55 -7.41 -0.41 1.65e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg11644478 chr21:40555479 PSMG1 -0.57 -7.9 -0.44 7.71e-14 Menarche (age at onset); CESC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg23248424 chr5:179741104 GFPT2 -0.64 -8.51 -0.46 1.29e-15 Height; CESC cis rs9291683 0.551 rs62295971 chr4:9978142 G/A cg00071950 chr4:10020882 SLC2A9 0.78 14.51 0.67 1.66e-35 Bone mineral density; CESC cis rs6499255 1.000 rs4464069 chr16:69816284 C/T cg15192750 chr16:69999425 NA 0.42 5.29 0.31 2.51e-7 IgE levels; CESC cis rs67257959 0.708 rs11671858 chr19:17201520 T/G cg16202187 chr19:17186497 HAUS8;MYO9B 0.43 5.19 0.3 4.26e-7 Selective IgA deficiency; CESC cis rs10870270 0.957 rs7074604 chr10:133740373 G/C cg26149184 chr10:133730230 NA 0.38 5.15 0.3 5.07e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs899997 1.000 rs11072794 chr15:79006582 A/G cg04896959 chr15:78267971 NA 0.41 6.4 0.37 6.96e-10 Coronary artery disease or large artery stroke; CESC cis rs2996428 0.667 rs7545274 chr1:3744261 G/T cg13057898 chr1:3703894 LRRC47 0.4 5.46 0.32 1.11e-7 Red cell distribution width; CESC cis rs2019216 0.542 rs12450889 chr17:21889379 A/G cg22648282 chr17:21454238 C17orf51 -0.41 -5.35 -0.31 1.9e-7 Pelvic organ prolapse; CESC cis rs9902453 0.933 rs2054846 chr17:28507693 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.97 -0.44 4.64e-14 Coffee consumption (cups per day); CESC cis rs1348850 0.914 rs1975544 chr2:178465423 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.67 8.61 0.47 6.58e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs963731 0.649 rs1454227 chr2:39249328 T/C cg04010122 chr2:39346883 SOS1 -0.69 -5.35 -0.31 1.91e-7 Corticobasal degeneration; CESC cis rs7085104 0.572 rs284856 chr10:104574329 A/T cg04362960 chr10:104952993 NT5C2 -0.47 -6.37 -0.36 8.3e-10 Immature fraction of reticulocytes;Schizophrenia; CESC trans rs1994135 0.647 rs1351681 chr12:33698724 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.31 0.41 3.17e-12 Resting heart rate; CESC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg03351412 chr1:154909251 PMVK 0.53 6.46 0.37 4.89e-10 Prostate cancer; CESC cis rs3774749 0.565 rs2518796 chr3:50207075 A/G cg24110177 chr3:50126178 RBM5 -0.39 -5.15 -0.3 5.21e-7 Intelligence (multi-trait analysis); CESC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.21 0.41 5.72e-12 Height; CESC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg18350739 chr11:68623251 NA -0.44 -6.3 -0.36 1.24e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg03709012 chr19:19516395 GATAD2A 0.96 14.18 0.66 2.35e-34 Tonsillectomy; CESC cis rs3806843 1.000 rs10072015 chr5:140170655 A/T cg26395211 chr5:140044315 WDR55 0.41 5.21 0.3 3.79e-7 Depressive symptoms (multi-trait analysis); CESC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.61 0.42 4.95e-13 Prudent dietary pattern; CESC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg08704250 chr15:31115839 NA -0.63 -8.2 -0.45 1.05e-14 Huntington's disease progression; CESC cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg18876405 chr7:65276391 NA -0.65 -9.06 -0.49 2.92e-17 Aortic root size; CESC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg25072359 chr17:41440525 NA 0.47 6.86 0.39 4.97e-11 Menopause (age at onset); CESC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg11663144 chr21:46675770 NA 0.46 6.35 0.36 9.36e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7647973 0.600 rs12631989 chr3:49273996 C/T cg02487422 chr3:49467188 NICN1 0.39 5.3 0.31 2.38e-7 Menarche (age at onset); CESC cis rs12410462 1.000 rs75652886 chr1:227654485 G/T cg23173402 chr1:227635558 NA 0.56 5.64 0.33 4.28e-8 Major depressive disorder; CESC cis rs9486719 1.000 rs34209750 chr6:96882215 G/T cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg12365402 chr11:9010492 NRIP3 -0.44 -7.44 -0.42 1.38e-12 Hemoglobin concentration; CESC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC trans rs10506458 1.000 rs1009539 chr12:63414655 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.27 17.35 0.73 1.48e-45 Hemostatic factors and hematological phenotypes; CESC cis rs9611565 0.649 rs5758442 chr22:42133060 T/C cg06481639 chr22:41940642 POLR3H 0.5 5.81 0.34 1.78e-8 Vitiligo; CESC cis rs6060717 0.536 rs6058356 chr20:34491530 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.54 5.17 0.3 4.73e-7 Hip circumference adjusted for BMI; CESC cis rs2243480 1.000 rs160644 chr7:65558186 C/T cg13147721 chr7:65941812 NA -0.98 -9.11 -0.49 2.06e-17 Diabetic kidney disease; CESC cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg18538332 chr22:24372958 LOC391322 0.72 9.35 0.5 3.78e-18 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs9863 0.861 rs7958691 chr12:124440743 G/T cg00084347 chr12:124393913 DNAH10 0.27 5.35 0.31 1.91e-7 White blood cell count; CESC cis rs2273669 0.667 rs79285264 chr6:109318279 G/T cg05315195 chr6:109294784 ARMC2 -0.66 -5.71 -0.33 3.03e-8 Prostate cancer; CESC trans rs3780486 0.846 rs10116966 chr9:33122370 T/A cg04842962 chr6:43655489 MRPS18A 1.0 19.43 0.77 6.71e-53 IgG glycosylation; CESC cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg12386194 chr3:101231763 SENP7 0.45 5.71 0.33 3.05e-8 Colorectal cancer; CESC cis rs2603127 0.724 rs2121766 chr3:108482513 G/C cg03329597 chr3:108125523 MYH15 0.6 5.38 0.31 1.62e-7 Hemostatic factors and hematological phenotypes; CESC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25020846 chr6:53659618 LRRC1 0.71 8.14 0.45 1.56e-14 Gut microbiome composition (summer); CESC cis rs7953249 0.618 rs7954039 chr12:121398654 A/C cg25281562 chr12:121454272 C12orf43 -0.46 -5.7 -0.33 3.12e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs11711311 0.869 rs12493635 chr3:113373019 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 5.93 0.34 9.45e-9 IgG glycosylation; CESC cis rs9486719 1.000 rs12212614 chr6:97036466 T/G cg06623918 chr6:96969491 KIAA0776 -0.8 -8.21 -0.45 9.56e-15 Migraine;Coronary artery disease; CESC cis rs2624839 0.704 rs12632110 chr3:50224225 A/G cg14019146 chr3:50243930 SLC38A3 0.3 5.08 0.3 7.04e-7 Intelligence (multi-trait analysis); CESC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg06221963 chr1:154839813 KCNN3 -0.66 -11.12 -0.56 8.07e-24 Prostate cancer; CESC cis rs3916 0.641 rs2393749 chr12:121131891 C/T cg26008908 chr12:120799332 MSI1 0.4 6.31 0.36 1.18e-9 Urinary metabolites (H-NMR features); CESC cis rs3768617 0.510 rs1413388 chr1:183096694 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs7599312 0.534 rs2128321 chr2:213405276 G/T cg16329650 chr2:213403929 ERBB4 0.57 8.68 0.47 4.16e-16 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs548181 0.536 rs503287 chr11:125461788 C/T cg03464685 chr11:125439445 EI24 0.98 8.07 0.44 2.44e-14 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs727505 1.000 rs6971909 chr7:124525517 C/T cg23710748 chr7:124431027 NA -0.4 -6.47 -0.37 4.6e-10 Lewy body disease; CESC cis rs7786877 0.521 rs4729606 chr7:100321790 T/C cg20848291 chr7:100343083 ZAN -0.7 -8.55 -0.46 1.02e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs914615 0.552 rs4421576 chr1:155142210 A/G cg02153340 chr1:155202674 NA -0.37 -5.39 -0.31 1.54e-7 Urinary albumin-to-creatinine ratio; CESC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg18876405 chr7:65276391 NA -0.49 -6.75 -0.38 9.38e-11 Aortic root size; CESC cis rs79839061 0.610 rs3736089 chr4:870118 G/A cg07828340 chr4:882639 GAK 1.07 8.28 0.45 6.09e-15 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26272228 chr1:95538484 ALG14 -0.47 -6.0 -0.35 6.36e-9 Fibrinogen levels; CESC cis rs9287719 0.967 rs6719701 chr2:10748283 G/A cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs208520 0.661 rs7766144 chr6:66827795 C/T cg07460842 chr6:66804631 NA -1.0 -13.37 -0.63 1.62e-31 Exhaled nitric oxide output; CESC cis rs7000551 0.527 rs11783730 chr8:22244897 C/T cg02463440 chr8:22132932 PIWIL2 0.41 5.1 0.3 6.44e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs7726839 0.540 rs61731455 chr5:665295 A/G cg16447950 chr5:562315 NA -0.62 -6.54 -0.37 3.09e-10 Obesity-related traits; CESC cis rs7267979 1.000 rs2259873 chr20:25280781 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs703842 0.739 rs701008 chr12:58117645 A/G cg18357645 chr12:58087776 OS9 -0.4 -5.97 -0.34 7.43e-9 Multiple sclerosis; CESC cis rs727505 0.564 rs57841320 chr7:124847732 T/A cg23710748 chr7:124431027 NA -0.33 -5.1 -0.3 6.44e-7 Lewy body disease; CESC cis rs2439831 1.000 rs565007 chr15:43716641 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.82 12.0 0.59 8.48e-27 Lung cancer in ever smokers; CESC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg03806693 chr22:41940476 POLR3H -1.23 -16.7 -0.72 2.8e-43 Vitiligo; CESC trans rs561341 0.739 rs8070554 chr17:30216868 A/T cg20587970 chr11:113659929 NA 0.59 7.53 0.42 7.85e-13 Hip circumference adjusted for BMI; CESC cis rs977987 0.654 rs8054194 chr16:75497160 G/T cg03315344 chr16:75512273 CHST6 0.48 6.72 0.38 1.12e-10 Dupuytren's disease; CESC cis rs4664304 0.802 rs3792175 chr2:160862804 T/A cg03641300 chr2:160917029 PLA2R1 -0.51 -7.17 -0.4 7.43e-12 Crohn's disease;Inflammatory bowel disease; CESC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg18350739 chr11:68623251 NA -0.43 -6.91 -0.39 3.5e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7818345 0.595 rs12155539 chr8:19316086 G/A cg11303988 chr8:19266685 CSGALNACT1 0.34 5.26 0.31 2.94e-7 Language performance in older adults (adjusted for episodic memory); CESC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg22920501 chr2:26401640 FAM59B 0.91 10.38 0.54 2.08e-21 Gut microbiome composition (summer); CESC cis rs2549003 1.000 rs2706384 chr5:131826880 G/T cg02551604 chr5:131831745 NA 0.37 5.25 0.31 3.09e-7 Asthma (sex interaction); CESC cis rs863345 0.967 rs863346 chr1:158535911 T/C cg12129480 chr1:158549410 OR10X1 -0.32 -6.46 -0.37 5.13e-10 Pneumococcal bacteremia; CESC cis rs875622 0.556 rs4808047 chr19:16527834 T/C cg10248733 chr19:16607483 C19orf44;CALR3 -0.59 -6.72 -0.38 1.12e-10 White matter integrity;Neutrophil percentage of white cells; CESC cis rs2228479 0.717 rs34027607 chr16:89808939 T/C cg27121462 chr16:89883253 FANCA 0.63 5.51 0.32 8.36e-8 Skin colour saturation; CESC cis rs9308731 1.000 rs6750599 chr2:111893869 A/T cg04202892 chr2:111875749 ACOXL -0.39 -5.61 -0.33 5.06e-8 Chronic lymphocytic leukemia; CESC cis rs9549367 0.789 rs12866090 chr13:113869410 G/A cg00898013 chr13:113819073 PROZ -0.53 -7.65 -0.43 3.67e-13 Platelet distribution width; CESC cis rs9399135 0.967 rs9389261 chr6:135371148 C/G cg22676075 chr6:135203613 NA 0.5 7.06 0.4 1.43e-11 Red blood cell count; CESC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg06481639 chr22:41940642 POLR3H -0.62 -6.55 -0.37 2.92e-10 Vitiligo; CESC cis rs6540555 0.505 rs11806703 chr1:209882906 A/T cg05527609 chr1:210001259 C1orf107 -0.72 -7.07 -0.4 1.37e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs2155929 0.660 rs16945950 chr18:26607602 C/T cg25413575 chr17:80870577 TBCD 0.42 6.06 0.35 4.54e-9 Temperament (bipolar disorder); CESC cis rs7264396 0.690 rs2425157 chr20:34419083 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.66 6.69 0.38 1.33e-10 Total cholesterol levels; CESC cis rs116095464 0.558 rs7714335 chr5:263513 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.22 0.31 3.67e-7 Breast cancer; CESC cis rs763121 0.853 rs5757162 chr22:38993370 C/T cg14440974 chr22:39074834 NA -0.4 -5.26 -0.31 2.98e-7 Menopause (age at onset); CESC cis rs2463822 0.858 rs2463836 chr11:62126494 A/G cg06239285 chr11:62104954 ASRGL1 0.86 8.63 0.47 5.79e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs1008375 0.932 rs6814465 chr4:17659034 C/T cg16339924 chr4:17578868 LAP3 0.68 8.66 0.47 4.83e-16 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04826284 chr12:66563885 TMBIM4 0.64 7.24 0.41 4.9e-12 Gut microbiome composition (summer); CESC cis rs8017423 0.935 rs12880102 chr14:90793526 G/T cg14092571 chr14:90743983 NA 0.54 8.19 0.45 1.11e-14 Mortality in heart failure; CESC cis rs1847202 0.859 rs13075769 chr3:72939295 C/T cg25664220 chr3:72788482 NA -0.42 -6.24 -0.36 1.7e-9 Motion sickness; CESC cis rs9611565 0.659 rs17367849 chr22:41923644 G/A cg03806693 chr22:41940476 POLR3H -1.2 -16.01 -0.7 8.02e-41 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04329845 chr19:14640100 MIR639;TECR 0.52 6.07 0.35 4.33e-9 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg00409905 chr10:38381863 ZNF37A -0.45 -5.96 -0.34 7.89e-9 Extrinsic epigenetic age acceleration; CESC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.79 -0.55 9.74e-23 Alzheimer's disease; CESC cis rs10779751 0.960 rs4845857 chr1:11285680 T/C cg08854313 chr1:11322531 MTOR 0.83 11.78 0.59 5.03e-26 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24305770 chr2:97217869 ARID5A -0.55 -6.12 -0.35 3.37e-9 Gut microbiome composition (summer); CESC cis rs7665590 1 rs7665590 chr4:99796784 T/C cg12011299 chr4:100065546 ADH4 -0.46 -6.38 -0.36 7.98e-10 Primary biliary cholangitis; CESC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.17e-12 Tonsillectomy; CESC cis rs2197308 0.549 rs10785517 chr12:38577992 G/T cg26384229 chr12:38710491 ALG10B 0.44 6.28 0.36 1.39e-9 Morning vs. evening chronotype; CESC cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs16854884 0.586 rs4527375 chr3:143735515 A/T cg06585982 chr3:143692056 C3orf58 -0.53 -7.39 -0.41 1.86e-12 Economic and political preferences (feminism/equality); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06369532 chr7:2155044 MAD1L1 -0.5 -6.22 -0.36 1.93e-9 Gut microbiome composition (summer); CESC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg21782813 chr7:2030301 MAD1L1 0.42 5.91 0.34 1.03e-8 Bipolar disorder and schizophrenia; CESC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg11494091 chr17:61959527 GH2 0.72 12.33 0.6 6.37e-28 Prudent dietary pattern; CESC trans rs4332037 0.575 rs55952733 chr7:2070680 G/A cg11693508 chr17:37793320 STARD3 0.66 6.66 0.38 1.57e-10 Bipolar disorder; CESC trans rs7824557 0.583 rs6601585 chr8:11233659 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -6.31 -0.36 1.14e-9 Retinal vascular caliber; CESC cis rs9858542 1.000 rs9858542 chr3:49701983 A/G cg03060546 chr3:49711283 APEH 0.55 6.59 0.38 2.34e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.49 -0.37 4.09e-10 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.45 0.54 1.29e-21 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05869119 chr2:176046457 ATP5G3 0.7 8.67 0.47 4.49e-16 Gut microbiome composition (summer); CESC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg09177884 chr7:1199841 ZFAND2A -0.49 -6.42 -0.37 6.31e-10 Longevity;Endometriosis; CESC cis rs748404 0.697 rs530188 chr15:43545314 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.61 8.07 0.44 2.39e-14 Lung cancer; CESC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.69 0.38 1.3100000000000001e-10 Prudent dietary pattern; CESC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg10578991 chr7:12443926 VWDE 0.49 6.45 0.37 5.37e-10 Coronary artery disease; CESC cis rs11098499 0.863 rs1383533 chr4:120434576 G/A cg24375607 chr4:120327624 NA 0.43 5.19 0.3 4.27e-7 Corneal astigmatism; CESC cis rs10752881 1.000 rs10797800 chr1:182969828 C/A ch.1.3577855R chr1:183094577 LAMC1 0.86 13.7 0.64 1.17e-32 Colorectal cancer; CESC cis rs1728785 0.901 rs821169 chr16:68630184 C/T cg02972257 chr16:68554789 NA -0.63 -7.01 -0.4 1.94e-11 Ulcerative colitis; CESC cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg10523679 chr1:76189770 ACADM 0.72 8.33 0.46 4.31e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs412050 1.000 rs56138298 chr22:22316540 G/A cg17089214 chr22:22089827 YPEL1 0.68 6.06 0.35 4.56e-9 Attention deficit hyperactivity disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24103018 chr19:17420930 DDA1 -0.43 -6.08 -0.35 4.23e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.76 12.32 0.6 7.05e-28 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11956146 chr18:21718974 CABYR -0.57 -6.74 -0.38 1.01e-10 Gut microbiome composition (summer); CESC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg14298792 chr15:30685198 CHRFAM7A -0.45 -5.43 -0.32 1.25e-7 Huntington's disease progression; CESC cis rs12986413 0.624 rs2159213 chr19:2136102 T/C cg09261902 chr19:2140048 AP3D1 0.34 5.35 0.31 1.91e-7 Height; CESC cis rs7833790 1.000 rs28696138 chr8:82770794 G/A cg02079420 chr8:82753780 SNX16 -0.58 -7.73 -0.43 2.18e-13 Diastolic blood pressure; CESC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg16545954 chr1:2118288 C1orf86 -0.31 -5.68 -0.33 3.45e-8 Height; CESC cis rs1045714 0.836 rs56246161 chr7:2644679 G/A cg20813462 chr7:2646259 IQCE 0.61 5.41 0.32 1.43e-7 Urate levels in lean individuals; CESC cis rs7927771 0.524 rs2869024 chr11:47674101 G/A cg18512352 chr11:47633146 NA -0.35 -5.37 -0.31 1.73e-7 Subjective well-being; CESC cis rs2594989 0.943 rs2442769 chr3:11491086 A/G cg00170343 chr3:11313890 ATG7 -0.57 -5.11 -0.3 6.17e-7 Circulating chemerin levels; CESC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg08470875 chr2:26401718 FAM59B -0.62 -6.69 -0.38 1.36e-10 Gut microbiome composition (summer); CESC cis rs7605827 0.930 rs6716384 chr2:15608210 A/G cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg07677032 chr17:61819896 STRADA 0.47 6.29 0.36 1.33e-9 Prudent dietary pattern; CESC cis rs6933660 0.800 rs2046371 chr6:151754744 G/A cg14262678 chr6:151773367 RMND1;C6orf211 0.62 8.55 0.46 1.02e-15 Menarche (age at onset); CESC cis rs1348850 0.567 rs880899 chr2:178532416 A/G cg22681709 chr2:178499509 PDE11A -0.48 -7.75 -0.43 1.95e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2243480 1.000 rs1723269 chr7:65472786 C/G cg12463550 chr7:65579703 CRCP 0.68 5.4 0.32 1.45e-7 Diabetic kidney disease; CESC cis rs7599312 0.553 rs6710653 chr2:213404893 A/G cg20637307 chr2:213403960 ERBB4 0.58 8.99 0.48 4.85e-17 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1975974 0.748 rs67473406 chr17:21726745 G/A cg18423549 chr17:21743878 NA -0.51 -6.94 -0.39 2.95e-11 Psoriasis; CESC cis rs4722166 0.630 rs13311155 chr7:22789789 A/C cg26061582 chr7:22766209 IL6 0.5 5.47 0.32 1.04e-7 Lung cancer; CESC cis rs1975974 1.000 rs7210944 chr17:21727476 C/T cg18423549 chr17:21743878 NA -0.54 -7.65 -0.43 3.81e-13 Psoriasis; CESC cis rs854765 0.505 rs4924832 chr17:17897739 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.52 6.8 0.39 6.92e-11 Total body bone mineral density; CESC cis rs4730250 0.669 rs6466160 chr7:106793175 T/A cg02696742 chr7:106810147 HBP1 0.55 5.18 0.3 4.36e-7 Osteoarthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09219019 chr3:182400155 NA 0.58 6.56 0.37 2.87e-10 Gut microbiome composition (summer); CESC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg18876405 chr7:65276391 NA -0.54 -7.58 -0.42 5.72e-13 Aortic root size; CESC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg11644478 chr21:40555479 PSMG1 -0.52 -6.98 -0.39 2.3e-11 Menarche (age at onset); CESC cis rs9303401 0.614 rs68100606 chr17:56500898 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.95 11.43 0.57 7.3e-25 Cognitive test performance; CESC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg17971929 chr21:40555470 PSMG1 1.08 16.32 0.71 6.44e-42 Cognitive function; CESC cis rs1008375 0.835 rs9760627 chr4:17651508 C/T cg15017067 chr4:17643749 FAM184B 0.37 5.11 0.3 6.26e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg03052760 chr1:35738702 ZMYM4 0.38 6.1 0.35 3.77e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01998146 chr9:15511358 PSIP1 -0.43 -6.0 -0.35 6.29e-9 Gambling; CESC cis rs9611565 0.729 rs203319 chr22:41914593 C/T cg03806693 chr22:41940476 POLR3H -0.86 -11.2 -0.57 4.39e-24 Vitiligo; CESC cis rs9811920 0.809 rs902159 chr3:99747445 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.4 5.21 0.3 3.76e-7 Axial length; CESC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg18876405 chr7:65276391 NA 0.51 5.96 0.34 8.21e-9 Aortic root size; CESC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.02 0.8 8.6e-62 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08473553 chr1:236304799 GPR137B 0.6 6.68 0.38 1.38e-10 Gut microbiome composition (summer); CESC cis rs9399135 0.967 rs12527707 chr6:135324511 G/A cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs1707322 0.717 rs3014246 chr1:46086077 C/T cg05343316 chr1:45956843 TESK2 -0.52 -6.42 -0.37 6.4e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12190007 0.604 rs7382308 chr6:169732276 A/C cg16388071 chr6:169726476 NA -0.53 -7.77 -0.43 1.78e-13 Obesity-related traits; CESC cis rs763121 0.853 rs5757213 chr22:39053888 C/T cg06544989 chr22:39130855 UNC84B 0.49 8.52 0.46 1.22e-15 Menopause (age at onset); CESC cis rs2860975 1.000 rs10159983 chr10:96774437 C/T cg09036531 chr10:96991505 NA -0.35 -5.05 -0.3 8.17e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs2535633 0.631 rs6799185 chr3:53101580 C/T cg11645453 chr3:52864694 ITIH4 0.27 5.17 0.3 4.52e-7 Body mass index; CESC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.53 -0.58 3.4e-25 Alzheimer's disease; CESC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg18099408 chr3:52552593 STAB1 -0.36 -6.1 -0.35 3.79e-9 Electroencephalogram traits; CESC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg22105103 chr4:187893119 NA 0.48 6.77 0.38 8.02e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7582720 1.000 rs114395475 chr2:203769112 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs2228479 0.850 rs17233448 chr16:89816424 G/T cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC trans rs11073464 1.000 rs1550232 chr15:96673131 T/C cg20048050 chr7:75911126 SRRM3 -0.49 -6.01 -0.35 5.96e-9 Facial morphology (factor 1, breadth of lateral portion of upper face); CESC cis rs7640424 0.659 rs7639774 chr3:107816216 T/G cg09227934 chr3:107805635 CD47 -0.44 -5.51 -0.32 8.42e-8 Body mass index; CESC trans rs1814175 0.817 rs12295885 chr11:50036762 T/G cg15704280 chr7:45808275 SEPT13 -1.06 -21.09 -0.79 1.24e-58 Height; CESC cis rs8013055 0.846 rs10151805 chr14:105974781 T/C cg23356831 chr14:105996513 TMEM121 0.37 5.14 0.3 5.23e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC trans rs561341 0.883 rs4795661 chr17:30201774 T/A cg20587970 chr11:113659929 NA 0.99 11.72 0.58 7.58e-26 Hip circumference adjusted for BMI; CESC cis rs9487051 0.621 rs448496 chr6:109540157 G/T cg01475377 chr6:109611718 NA -0.4 -5.3 -0.31 2.41e-7 Reticulocyte fraction of red cells; CESC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg17971929 chr21:40555470 PSMG1 -0.86 -12.5 -0.61 1.75e-28 Cognitive function; CESC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg27165867 chr14:105738592 BRF1 0.48 5.98 0.34 7.25e-9 Mean platelet volume;Platelet distribution width; CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg15147215 chr3:52552868 STAB1 -0.37 -6.77 -0.38 8.34e-11 Electroencephalogram traits; CESC cis rs4727027 0.680 rs6464941 chr7:148826352 A/G cg23583168 chr7:148888333 NA -0.69 -9.45 -0.5 1.92e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg16339924 chr4:17578868 LAP3 0.54 6.65 0.38 1.63e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9457247 0.663 rs2282860 chr6:167440244 T/C cg25258033 chr6:167368657 RNASET2 0.37 5.4 0.31 1.51e-7 Crohn's disease; CESC cis rs1728785 1.000 rs1645923 chr16:68581051 G/A cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs4746818 1.000 rs4746818 chr10:70884687 G/T cg04149295 chr10:70884716 VPS26A 0.64 6.93 0.39 3.26e-11 Left atrial antero-posterior diameter; CESC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.59 0.38 2.35e-10 Bipolar disorder; CESC cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 3.05e-8 Mean platelet volume; CESC trans rs1545843 0.564 rs1459614 chr12:84890003 C/T cg03015433 chr16:56623111 MT3 0.33 6.1 0.35 3.76e-9 Major depressive disorder; CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.02 0.4 1.89e-11 Bipolar disorder; CESC cis rs734999 0.588 rs60520190 chr1:2533706 G/A cg18854424 chr1:2615690 NA 0.28 5.41 0.32 1.43e-7 Ulcerative colitis; CESC cis rs367615 0.918 rs17161895 chr5:108855831 T/G cg17395555 chr5:108820864 NA 0.54 8.01 0.44 3.6e-14 Colorectal cancer (SNP x SNP interaction); CESC cis rs9300255 0.596 rs10734901 chr12:123743447 G/A cg00376283 chr12:123451042 ABCB9 0.66 8.97 0.48 5.43e-17 Neutrophil percentage of white cells; CESC cis rs858239 0.600 rs6461690 chr7:23135534 A/G cg23682824 chr7:23144976 KLHL7 0.55 7.61 0.42 4.84e-13 Cerebrospinal fluid biomarker levels; CESC cis rs2777491 1.000 rs2730055 chr15:41735708 C/A cg02330683 chr15:41787940 ITPKA 0.47 7.03 0.4 1.76e-11 Ulcerative colitis; CESC cis rs7647973 1.000 rs3905330 chr3:49550774 A/G cg07636037 chr3:49044803 WDR6 0.7 10.31 0.53 3.6e-21 Menarche (age at onset); CESC cis rs6867032 1.000 rs4398675 chr5:2015816 G/A cg26168224 chr5:2018326 NA 0.96 19.55 0.77 2.72e-53 Gut microbiome composition (winter); CESC cis rs727563 0.636 rs2187795 chr22:42092225 C/A cg06481639 chr22:41940642 POLR3H 0.59 5.91 0.34 1.05e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.63 -0.33 4.6e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg24675658 chr1:53192096 ZYG11B -0.52 -6.37 -0.36 8.1e-10 Monocyte count; CESC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg11965913 chr1:205819406 PM20D1 0.47 6.95 0.39 2.87e-11 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27397943 chr8:81397668 ZBTB10 -0.63 -7.67 -0.43 3.21e-13 Gut microbiome composition (summer); CESC cis rs1190552 0.846 rs1061924 chr14:102975655 C/T cg18135206 chr14:102964638 TECPR2 0.42 5.33 0.31 2.15e-7 Blood protein levels; CESC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg17949981 chr6:28129498 ZNF389 0.43 5.43 0.32 1.29e-7 Parkinson's disease; CESC cis rs9906944 0.713 rs9899580 chr17:47106878 T/G cg09029085 chr17:47094198 IGF2BP1 0.25 5.06 0.3 7.94e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs17095355 1.000 rs55897175 chr10:111699190 C/T cg00817464 chr10:111662876 XPNPEP1 -0.43 -5.23 -0.31 3.37e-7 Biliary atresia; CESC cis rs9467711 0.606 rs9379897 chr6:26601526 T/C cg14345882 chr6:26364793 BTN3A2 0.56 6.06 0.35 4.58e-9 Autism spectrum disorder or schizophrenia; CESC cis rs644799 0.544 rs56298021 chr11:95545113 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.57 7.62 0.42 4.45e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg10556349 chr10:835070 NA 0.74 6.29 0.36 1.33e-9 Eosinophil percentage of granulocytes; CESC cis rs7267979 0.966 rs2261698 chr20:25259910 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.21e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs644799 0.544 rs1254935 chr11:95631470 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.47 6.04 0.35 5.3300000000000004e-09 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs77216612 0.877 rs66561220 chr12:12878765 T/C cg24098013 chr12:12878779 APOLD1 0.57 6.89 0.39 4.1e-11 Lymphocyte counts; CESC cis rs2594989 1.000 rs2594994 chr3:11339960 T/A cg00170343 chr3:11313890 ATG7 0.59 5.22 0.31 3.7e-7 Circulating chemerin levels; CESC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg10691866 chr7:65817282 TPST1 -0.35 -5.86 -0.34 1.41e-8 Aortic root size; CESC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg11905131 chr22:24372483 LOC391322 -0.62 -8.61 -0.47 6.55e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6546550 0.867 rs1551374 chr2:70079633 C/T cg02498382 chr2:70120550 SNRNP27 -0.37 -6.46 -0.37 5.05e-10 Prevalent atrial fibrillation; CESC cis rs7178572 0.568 rs12916731 chr15:77507021 C/T cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC trans rs677325 0.604 rs4561007 chr1:191557292 A/T cg03168947 chr3:42201649 TRAK1 -0.48 -5.99 -0.35 6.65e-9 Subjective well-being (multi-trait analysis); CESC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg03538708 chr1:25844672 NA 0.4 5.96 0.34 7.85e-9 Erythrocyte sedimentation rate; CESC cis rs6499129 1.000 rs2089401 chr16:67549653 G/C cg26727032 chr16:67993705 SLC12A4 -0.56 -6.26 -0.36 1.53e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg01579765 chr21:45077557 HSF2BP -0.58 -10.18 -0.53 9.14e-21 Mean corpuscular volume; CESC trans rs1814175 0.527 rs7110797 chr11:49644096 T/C cg15704280 chr7:45808275 SEPT13 -0.88 -10.76 -0.55 1.19e-22 Height; CESC cis rs28680850 0.541 rs4876041 chr8:1370441 T/C cg06035437 chr8:1398411 NA -0.49 -5.24 -0.31 3.22e-7 Triglycerides; CESC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg09365446 chr1:150670422 GOLPH3L -0.39 -5.47 -0.32 1.04e-7 Tonsillectomy; CESC cis rs3857536 0.813 rs9360189 chr6:66933424 A/C cg07460842 chr6:66804631 NA -0.42 -5.36 -0.31 1.8e-7 Blood trace element (Cu levels); CESC cis rs9399135 0.636 rs7749106 chr6:135268142 G/A cg24558204 chr6:135376177 HBS1L 0.55 7.84 0.43 1.1e-13 Red blood cell count; CESC trans rs877282 0.898 rs11253352 chr10:766598 C/A cg22713356 chr15:30763199 NA 1.16 11.4 0.57 9.19e-25 Uric acid levels; CESC cis rs2243480 1.000 rs6964530 chr7:65718851 G/C cg12463550 chr7:65579703 CRCP -0.74 -5.8 -0.34 1.86e-8 Diabetic kidney disease; CESC cis rs593982 0.920 rs72939198 chr11:65438079 G/A cg08755490 chr11:65554678 OVOL1 -1.21 -8.9 -0.48 9.17e-17 Atopic dermatitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00433081 chr5:179719502 MAPK9 0.51 6.23 0.36 1.8e-9 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 8.23 0.45 8.74e-15 Bipolar disorder; CESC cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg01579765 chr21:45077557 HSF2BP -0.57 -9.98 -0.52 3.98e-20 Mean corpuscular volume; CESC cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg25554036 chr4:6271136 WFS1 0.55 8.68 0.47 4.02e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1506636 1.000 rs2215554 chr7:123347063 A/C cg03229431 chr7:123269106 ASB15 -0.46 -5.84 -0.34 1.49e-8 Plateletcrit;Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19345821 chr19:41107372 LTBP4 0.58 6.97 0.39 2.44e-11 Gut microbiome composition (summer); CESC cis rs11792861 0.962 rs3750454 chr9:111801325 C/G cg05043794 chr9:111880884 C9orf5 0.43 7.24 0.41 4.72e-12 Menarche (age at onset); CESC cis rs4604732 0.588 rs7552443 chr1:247628583 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.53 6.57 0.37 2.7e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs644799 1.000 rs560854 chr11:95584905 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.92 12.96 0.62 4.42e-30 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7267979 1.000 rs2257809 chr20:25266476 C/T cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs5756813 0.661 rs2285177 chr22:38205894 A/G cg19894588 chr14:64061835 NA -0.62 -7.99 -0.44 4.25e-14 Optic cup area;Vertical cup-disc ratio; CESC cis rs36051895 0.697 rs11788790 chr9:5092263 G/T cg02405213 chr9:5042618 JAK2 -0.54 -6.57 -0.37 2.58e-10 Pediatric autoimmune diseases; CESC cis rs3818285 0.544 rs7899805 chr10:111671177 G/A cg00817464 chr10:111662876 XPNPEP1 -0.51 -7.11 -0.4 1.11e-11 Superior crus of antihelix expression; CESC cis rs2637266 0.783 rs846642 chr10:78522318 A/G cg18941641 chr10:78392320 NA -0.41 -7.82 -0.43 1.28e-13 Pulmonary function; CESC cis rs854765 0.654 rs11078400 chr17:17757728 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.6 -8.95 -0.48 6.29e-17 Total body bone mineral density; CESC cis rs138880 0.542 rs9616210 chr22:50317346 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.68 -5.5 -0.32 8.95e-8 Schizophrenia; CESC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg04772025 chr11:68637568 NA 0.55 6.49 0.37 4.17e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs34638657 0.702 rs67612167 chr16:82199598 A/G cg09439754 chr16:82129088 HSD17B2 -0.37 -6.47 -0.37 4.62e-10 Lung adenocarcinoma; CESC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.59 0.32 5.76e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs763121 1.000 rs86796 chr22:38881454 A/C cg06544989 chr22:39130855 UNC84B -0.44 -7.77 -0.43 1.68e-13 Menopause (age at onset); CESC cis rs523522 0.962 rs4767904 chr12:120930798 T/G cg12219531 chr12:120966889 COQ5 0.75 9.9 0.52 7.22e-20 High light scatter reticulocyte count; CESC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg17372223 chr3:52568218 NT5DC2 0.43 6.5 0.37 4.08e-10 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19786784 chr17:35716113 ACACA -0.41 -6.1 -0.35 3.66e-9 Gambling; CESC cis rs7684253 0.565 rs13108570 chr4:57807083 G/C cg21154227 chr4:57904332 IGFBP7 0.37 5.28 0.31 2.67e-7 Migraine; CESC cis rs710216 0.957 rs841570 chr1:43435571 C/G cg03128534 chr1:43423976 SLC2A1 0.55 6.33 0.36 1.03e-9 Red cell distribution width; CESC cis rs67311347 1.000 rs10510708 chr3:40404770 A/G cg09455208 chr3:40491958 NA 0.42 7.09 0.4 1.2e-11 Renal cell carcinoma; CESC cis rs6963495 0.818 rs73192144 chr7:105203535 C/T cg13798780 chr7:105162888 PUS7 0.71 7.06 0.4 1.48e-11 Bipolar disorder (body mass index interaction); CESC cis rs5753037 0.653 rs105311 chr22:30137262 G/A cg01021169 chr22:30184971 ASCC2 -0.47 -6.6 -0.38 2.23e-10 Type 1 diabetes; CESC cis rs2522056 1.000 rs2522050 chr5:131796609 C/T cg24060327 chr5:131705240 SLC22A5 0.58 6.48 0.37 4.33e-10 Lymphocyte counts;Fibrinogen; CESC cis rs9549367 0.713 rs3024756 chr13:113822950 G/C cg00898013 chr13:113819073 PROZ -0.49 -6.94 -0.39 2.95e-11 Platelet distribution width; CESC cis rs7605827 0.897 rs12692274 chr2:15707711 A/G cg19274914 chr2:15703543 NA 0.36 6.39 0.37 7.3e-10 Educational attainment (years of education); CESC cis rs2439831 0.867 rs28461955 chr15:43661459 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.92 11.29 0.57 2.11e-24 Lung cancer in ever smokers; CESC cis rs7927771 0.507 rs12366244 chr11:47882130 C/A cg20307385 chr11:47447363 PSMC3 0.63 8.84 0.48 1.39e-16 Subjective well-being; CESC cis rs116095464 0.558 rs10059907 chr5:205360 G/C cg16372103 chr5:203701 NA 0.49 5.29 0.31 2.6e-7 Breast cancer; CESC trans rs427691 0.625 rs845739 chr5:109018540 G/T cg00054525 chr16:88717587 CYBA -0.61 -6.4 -0.37 7.03e-10 Autism spectrum disorder or schizophrenia; CESC trans rs1814175 0.509 rs60698301 chr11:49877672 G/A cg15704280 chr7:45808275 SEPT13 -0.98 -18.2 -0.75 1.48e-48 Height; CESC cis rs10927875 0.894 rs34957618 chr1:16320499 G/C cg21214613 chr1:16344536 HSPB7 -0.38 -5.78 -0.33 2.1e-8 Dilated cardiomyopathy; CESC cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg06212747 chr3:49208901 KLHDC8B 0.68 8.05 0.44 2.84e-14 Menarche (age at onset); CESC cis rs6546550 0.935 rs60207187 chr2:70093910 G/A cg02498382 chr2:70120550 SNRNP27 -0.35 -6.08 -0.35 4.22e-9 Prevalent atrial fibrillation; CESC cis rs10751667 0.666 rs6597966 chr11:950750 T/C cg06064525 chr11:970664 AP2A2 -0.47 -9.39 -0.5 2.9e-18 Alzheimer's disease (late onset); CESC cis rs4835473 0.897 rs56334914 chr4:144657444 G/C cg25736465 chr4:144833511 NA -0.32 -5.07 -0.3 7.49e-7 Immature fraction of reticulocytes; CESC cis rs9916302 0.680 rs2271308 chr17:37817482 T/C cg07936489 chr17:37558343 FBXL20 -0.55 -6.8 -0.39 7.06e-11 Glomerular filtration rate (creatinine); CESC cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg02079420 chr8:82753780 SNX16 0.55 8.2 0.45 1.01e-14 Diastolic blood pressure; CESC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6121246 0.529 rs6060210 chr20:30187681 C/T cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs2243480 1.000 rs2707831 chr7:66062511 G/A cg18252515 chr7:66147081 NA -1.39 -14.25 -0.66 1.31e-34 Diabetic kidney disease; CESC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.85 8.83 0.48 1.5e-16 Platelet count; CESC cis rs12477438 0.520 rs7605843 chr2:99811894 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 15.95 0.7 1.34e-40 Chronic sinus infection; CESC cis rs7809950 0.954 rs2712193 chr7:107125885 A/C cg23024343 chr7:107201750 COG5 -0.42 -5.86 -0.34 1.37e-8 Coronary artery disease; CESC cis rs6088580 0.634 rs6059866 chr20:33075810 A/C cg24642439 chr20:33292090 TP53INP2 0.51 7.02 0.4 1.82e-11 Glomerular filtration rate (creatinine); CESC cis rs6088580 0.634 rs6088498 chr20:33020446 A/G cg24642439 chr20:33292090 TP53INP2 0.49 6.64 0.38 1.76e-10 Glomerular filtration rate (creatinine); CESC trans rs61931739 0.500 rs11053235 chr12:34507899 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.31e-22 Morning vs. evening chronotype; CESC cis rs4660306 1.000 rs6667191 chr1:45982844 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.62 -7.74 -0.43 2.14e-13 Homocysteine levels; CESC cis rs7395581 0.918 rs1375688 chr11:47327217 G/A cg25783544 chr11:47291846 MADD 0.61 7.92 0.44 6.78e-14 HDL cholesterol; CESC cis rs2742234 0.590 rs741968 chr10:43611708 A/G cg07801480 chr10:43725741 RASGEF1A 0.42 5.54 0.32 7.23e-8 Hirschsprung disease; CESC cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 10.17 0.53 9.83e-21 Platelet count; CESC cis rs2228479 0.717 rs1800358 chr16:89809319 T/C cg14709524 chr16:89940631 TCF25 0.63 5.69 0.33 3.43e-8 Skin colour saturation; CESC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.32 -5.39 -0.31 1.55e-7 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02660119 chr19:56196747 EPN1 0.5 6.4 0.37 7.07e-10 Fibrinogen levels; CESC cis rs727505 1.000 rs10264060 chr7:124486413 C/A cg23710748 chr7:124431027 NA -0.46 -7.35 -0.41 2.4e-12 Lewy body disease; CESC cis rs1008375 1.000 rs2315556 chr4:17670861 T/C cg16339924 chr4:17578868 LAP3 0.53 6.67 0.38 1.5e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs55728055 0.661 rs9621295 chr22:32007153 G/A cg01338084 chr22:32026380 PISD 1.18 7.86 0.43 9.68e-14 Age-related hearing impairment; CESC cis rs8050907 0.661 rs17137056 chr16:4524685 G/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs11098499 0.909 rs35165976 chr4:120325630 G/A cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC trans rs1973993 0.745 rs6686016 chr1:96948002 G/A cg10631902 chr5:14652156 NA -0.46 -6.22 -0.36 1.93e-9 Weight; CESC trans rs4843747 0.671 rs28465438 chr16:88103714 G/A cg26811252 chr16:29126840 RRN3P2 0.68 9.43 0.5 2.15e-18 Menopause (age at onset); CESC cis rs2637266 0.703 rs2583062 chr10:78558472 T/C cg18941641 chr10:78392320 NA 0.41 7.83 0.43 1.17e-13 Pulmonary function; CESC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg08859206 chr1:53392774 SCP2 -0.58 -7.47 -0.42 1.19e-12 Monocyte count; CESC trans rs2659546 1.000 rs2732512 chr4:102033997 C/T cg08154348 chr6:84562930 RIPPLY2 0.5 6.11 0.35 3.54e-9 Corneal structure; CESC cis rs9814567 0.752 rs6779294 chr3:134329821 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.09 -0.3 6.84e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2228479 0.850 rs17233567 chr16:89813821 G/A cg06558623 chr16:89946397 TCF25 1.19 9.55 0.51 8.99e-19 Skin colour saturation; CESC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg21770322 chr7:97807741 LMTK2 0.57 8.68 0.47 4.01e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs804280 0.638 rs36038176 chr8:11609995 C/T cg26752888 chr8:11627280 NEIL2 0.68 6.09 0.35 4.03e-9 Myopia (pathological); CESC trans rs2882926 0.640 rs35460576 chr8:63523665 T/C cg07243138 chr11:105169034 NA -0.6 -6.14 -0.35 2.94e-9 Periodontitis (PAL4Q3); CESC cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4888262 0.508 rs4888258 chr16:74634198 G/T cg01733217 chr16:74700730 RFWD3 0.85 11.82 0.59 3.53e-26 Testicular germ cell tumor; CESC cis rs6952808 0.931 rs12537479 chr7:1868995 A/G cg22963979 chr7:1858916 MAD1L1 0.41 5.68 0.33 3.62e-8 Bipolar disorder and schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09098825 chr3:47866946 DHX30 -0.47 -6.26 -0.36 1.56e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10089 1.000 rs7713877 chr5:127428825 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.19 0.53 8.66e-21 Ileal carcinoids; CESC cis rs3733585 0.673 rs4235348 chr4:9951968 T/C cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg00310523 chr12:86230176 RASSF9 0.38 5.85 0.34 1.44e-8 Major depressive disorder; CESC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Depression; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14280098 chr1:791298 NA -0.37 -6.31 -0.36 1.17e-9 Gambling; CESC cis rs548181 0.736 rs497344 chr11:125470524 T/C cg03464685 chr11:125439445 EI24 1.01 8.56 0.47 9.45e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9522267 0.737 rs7330902 chr13:112227599 C/T cg10483660 chr13:112241077 NA -0.3 -5.07 -0.3 7.43e-7 Hepatitis; CESC cis rs116095464 0.558 rs1541822 chr5:269234 A/C cg22857025 chr5:266934 NA 1.24 17.25 0.73 3.14e-45 Breast cancer; CESC cis rs12325245 0.536 rs17821543 chr16:58540875 C/T cg02549819 chr16:58548995 SETD6 0.88 6.43 0.37 5.93e-10 Schizophrenia; CESC cis rs60154123 0.730 rs652241 chr1:210465029 A/T cg23283495 chr1:209979779 IRF6 0.41 5.36 0.31 1.79e-7 Coronary artery disease; CESC trans rs208520 0.690 rs2208442 chr6:66867004 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.89 -0.62 7.46e-30 Exhaled nitric oxide output; CESC cis rs8141529 0.509 rs5762853 chr22:29245231 T/G cg02153584 chr22:29168773 CCDC117 0.57 7.48 0.42 1.1e-12 Lymphocyte counts; CESC cis rs722599 0.748 rs929579 chr14:75330697 C/T cg11812906 chr14:75593930 NEK9 -0.43 -5.36 -0.31 1.81e-7 IgG glycosylation; CESC cis rs7586879 0.559 rs13387729 chr2:25076126 A/G cg01884057 chr2:25150051 NA 0.37 7.18 0.4 7.06e-12 Body mass index; CESC trans rs9329221 0.935 rs3750310 chr8:10283426 G/A cg06636001 chr8:8085503 FLJ10661 -0.56 -6.51 -0.37 3.84e-10 Neuroticism; CESC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.72 9.83 0.52 1.25e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs644799 1.000 rs563653 chr11:95561488 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.27 0.66 1.19e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.72 0.47 3.03e-16 Menopause (age at onset); CESC cis rs2249625 0.874 rs2463726 chr6:72895193 C/A cg18830697 chr6:72922368 RIMS1 -0.37 -5.31 -0.31 2.35e-7 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs1185460 0.967 rs1784302 chr11:118940957 C/G cg01677386 chr11:118938358 VPS11 -0.43 -5.47 -0.32 1.05e-7 Coronary artery disease; CESC trans rs1814175 0.645 rs1722000 chr11:49917928 A/C cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs748404 0.631 rs1133395 chr15:43650384 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.14 0.45 1.54e-14 Lung cancer; CESC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg14820908 chr5:178986412 RUFY1 0.4 5.85 0.34 1.47e-8 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08633134 chr19:50935017 MYBPC2 -0.45 -6.07 -0.35 4.41e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18346038 chr20:33264828 PIGU -0.62 -7.34 -0.41 2.57e-12 Gut microbiome composition (summer); CESC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg02951883 chr7:2050386 MAD1L1 -0.48 -6.13 -0.35 3.25e-9 Bipolar disorder and schizophrenia; CESC cis rs6690583 0.524 rs6680422 chr1:85451945 C/T cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs10463316 0.832 rs152087 chr5:150734419 C/T cg03212797 chr5:150827313 SLC36A1 -0.48 -6.07 -0.35 4.53e-9 Metabolite levels (Pyroglutamine); CESC cis rs72627123 0.867 rs58894370 chr14:74485382 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.82 0.34 1.74e-8 Morning vs. evening chronotype; CESC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg18252515 chr7:66147081 NA -0.44 -5.74 -0.33 2.62e-8 Aortic root size; CESC cis rs4253772 0.745 rs78023664 chr22:46647844 G/A cg00784671 chr22:46762841 CELSR1 -0.65 -5.99 -0.35 6.66e-9 LDL cholesterol;Cholesterol, total; CESC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg25036284 chr2:26402008 FAM59B -0.85 -9.25 -0.49 7.86e-18 Gut microbiome composition (summer); CESC trans rs931812 0.757 rs4734014 chr8:101908844 A/G cg20993868 chr7:22813445 NA 0.42 6.45 0.37 5.25e-10 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs4835473 0.932 rs13148097 chr4:144897391 G/A cg25736465 chr4:144833511 NA 0.4 6.1 0.35 3.74e-9 Immature fraction of reticulocytes; CESC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.57 0.77 2.19e-53 Height; CESC cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7107174 1.000 rs55825352 chr11:78034424 C/T cg02023728 chr11:77925099 USP35 0.52 6.84 0.39 5.45e-11 Testicular germ cell tumor; CESC cis rs12318506 0.826 rs11180452 chr12:75693881 G/T cg04728562 chr12:75699417 CAPS2 -0.94 -6.7 -0.38 1.24e-10 Coronary artery calcification; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13546538 chr9:111754815 CTNNAL1 0.43 6.16 0.35 2.66e-9 Fibrinogen levels; CESC cis rs11764590 0.694 rs60626033 chr7:2099719 A/G cg21782813 chr7:2030301 MAD1L1 -0.43 -5.44 -0.32 1.24e-7 Neuroticism; CESC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg19592336 chr6:28129416 ZNF389 0.58 7.33 0.41 2.75e-12 Parkinson's disease; CESC cis rs6920364 1 rs6920364 chr6:167376466 G/C cg23791538 chr6:167370224 RNASET2 0.58 8.26 0.45 7.1e-15 Lung cancer; CESC cis rs910316 0.737 rs175071 chr14:75498177 A/G cg08847533 chr14:75593920 NEK9 -0.91 -16.46 -0.71 2.11e-42 Height; CESC cis rs854765 0.547 rs4643387 chr17:17972973 C/T cg16928487 chr17:17741425 SREBF1 -0.56 -9.36 -0.5 3.66e-18 Total body bone mineral density; CESC cis rs11252926 0.583 rs4881333 chr10:519164 G/C cg03684893 chr10:554711 DIP2C -0.41 -6.26 -0.36 1.56e-9 Psychosis in Alzheimer's disease; CESC cis rs1256061 0.603 rs1256044 chr14:64734027 G/A cg21174375 chr14:64681225 SYNE2 0.51 6.82 0.39 6.15e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs72772090 0.539 rs11746534 chr5:96124807 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.26 -0.31 3.01e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11722228 0.549 rs62288521 chr4:10099772 G/A cg14348967 chr4:10160060 NA -0.41 -5.13 -0.3 5.48e-7 Gout;Urate levels;Serum uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05993306 chr5:137090649 HNRNPA0 -0.57 -6.46 -0.37 4.85e-10 Gut microbiome composition (summer); CESC cis rs9399137 0.507 rs7771310 chr6:135272535 G/A cg22676075 chr6:135203613 NA 0.56 7.13 0.4 9.67e-12 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7829975 0.511 rs2980426 chr8:8145609 T/C cg15556689 chr8:8085844 FLJ10661 0.56 6.78 0.38 7.9e-11 Mood instability; CESC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs2204008 0.687 rs2320523 chr12:38251397 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.61 0.33 5.13e-8 Bladder cancer; CESC cis rs4423214 0.879 rs1630498 chr11:71150785 A/C cg05163923 chr11:71159392 DHCR7 -0.59 -6.83 -0.39 5.72e-11 Vitamin D levels; CESC cis rs7927592 0.913 rs67005337 chr11:68307758 A/C cg20283391 chr11:68216788 NA -0.62 -7.45 -0.42 1.31e-12 Total body bone mineral density; CESC cis rs2625529 0.526 rs16956623 chr15:72536695 T/C cg16672083 chr15:72433130 SENP8 0.47 6.86 0.39 4.79e-11 Red blood cell count; CESC cis rs11958404 0.860 rs7723564 chr5:157449396 C/T cg05962755 chr5:157440814 NA 0.65 7.15 0.4 8.68e-12 IgG glycosylation; CESC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg22903471 chr2:27725779 GCKR -0.49 -6.95 -0.39 2.9100000000000002e-11 Menopause (age at onset); CESC cis rs4077515 0.806 rs3812564 chr9:139271190 A/G cg14169450 chr9:139327907 INPP5E 0.41 5.9 0.34 1.1e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg06505273 chr16:24850292 NA 0.53 6.49 0.37 4.27e-10 Intelligence (multi-trait analysis); CESC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg10800226 chr5:1850261 NA 0.36 5.91 0.34 1.06e-8 Cardiovascular disease risk factors; CESC cis rs4319547 0.741 rs4758663 chr12:122939483 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -6.22 -0.36 1.92e-9 Body mass index; CESC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg23758822 chr17:41437982 NA 1.03 14.48 0.66 2.1e-35 Menopause (age at onset); CESC trans rs2797160 0.651 rs1269176 chr6:126029682 A/T cg05039488 chr6:79577232 IRAK1BP1 -0.49 -6.64 -0.38 1.72e-10 Endometrial cancer; CESC cis rs6500602 0.702 rs17761816 chr16:4548832 C/G cg08645402 chr16:4508243 NA 0.55 9.03 0.48 3.72e-17 Schizophrenia; CESC cis rs4555082 0.834 rs28489970 chr14:105748862 T/C cg06808227 chr14:105710500 BRF1 -0.55 -6.17 -0.35 2.56e-9 Mean platelet volume;Platelet distribution width; CESC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.38 -6.81 -0.39 6.39e-11 Bipolar disorder; CESC cis rs477895 0.568 rs12418035 chr11:63871558 G/A cg04317338 chr11:64019027 PLCB3 0.83 8.62 0.47 6.11e-16 Mean platelet volume; CESC cis rs9443189 0.570 rs72888705 chr6:76403114 A/G cg01950844 chr6:76311363 SENP6 0.88 9.29 0.5 6.05e-18 Prostate cancer; CESC cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg11812906 chr14:75593930 NEK9 -0.89 -14.78 -0.67 1.81e-36 Height; CESC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg24675658 chr1:53192096 ZYG11B 0.52 6.36 0.36 8.65e-10 Monocyte count; CESC cis rs2070997 0.607 rs3808821 chr9:133712801 G/T cg11464064 chr9:133710261 ABL1 -0.74 -8.81 -0.48 1.64e-16 Response to amphetamines; CESC cis rs9790314 1.000 rs1993891 chr3:161047467 A/G cg04691961 chr3:161091175 C3orf57 -0.42 -5.31 -0.31 2.3e-7 Morning vs. evening chronotype; CESC cis rs9902453 0.808 rs10445400 chr17:28183059 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 8.19 0.45 1.08e-14 Coffee consumption (cups per day); CESC cis rs561341 1.000 rs564714 chr17:30318404 C/T cg00745463 chr17:30367425 LRRC37B -0.86 -7.76 -0.43 1.8e-13 Hip circumference adjusted for BMI; CESC trans rs12492269 0.702 rs41381644 chr3:178161614 A/G cg23502966 chr3:195789749 TFRC 0.61 6.0 0.35 6.45e-9 Plasma clusterin levels; CESC cis rs2242194 0.844 rs11264295 chr1:154987526 C/T cg09359103 chr1:154839909 KCNN3 -0.4 -6.38 -0.37 7.66e-10 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06854502 chr1:19923593 C1orf151 0.56 6.26 0.36 1.52e-9 Gut microbiome composition (summer); CESC cis rs832540 0.966 rs252923 chr5:56205662 T/G cg24531977 chr5:56204891 C5orf35 -0.45 -5.65 -0.33 4.12e-8 Coronary artery disease; CESC cis rs28374715 0.635 rs112547435 chr15:41648737 C/G cg02330683 chr15:41787940 ITPKA 0.42 5.36 0.31 1.77e-7 Ulcerative colitis; CESC cis rs2120019 0.938 rs8028632 chr15:75321262 T/C cg09165964 chr15:75287851 SCAMP5 -0.8 -9.94 -0.52 5.37e-20 Blood trace element (Zn levels); CESC trans rs829883 0.932 rs249840 chr12:98871993 T/C cg04550079 chr16:67212681 KIAA0895L -0.38 -6.2 -0.36 2.1e-9 Colorectal adenoma (advanced); CESC cis rs2404602 0.660 rs11852777 chr15:76929792 A/G cg23625390 chr15:77176239 SCAPER -0.45 -6.25 -0.36 1.62e-9 Blood metabolite levels; CESC cis rs6424115 0.830 rs3123554 chr1:24196401 C/T cg10978503 chr1:24200527 CNR2 -0.34 -6.83 -0.39 5.94e-11 Immature fraction of reticulocytes; CESC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg09263875 chr16:632152 PIGQ 0.68 11.94 0.59 1.43e-26 Height; CESC cis rs9811920 0.931 rs7629487 chr3:99860401 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.44 7.04 0.4 1.65e-11 Axial length; CESC cis rs9796 0.621 rs11858678 chr15:41467932 A/G cg12386646 chr15:41787261 ITPKA 0.33 5.11 0.3 6.05e-7 Menopause (age at onset); CESC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg26314531 chr2:26401878 FAM59B -0.78 -8.04 -0.44 2.91e-14 Gut microbiome composition (summer); CESC cis rs4566357 0.595 rs6707286 chr2:227911400 A/G cg05526886 chr2:227700861 RHBDD1 -0.45 -5.99 -0.35 6.98e-9 Coronary artery disease; CESC cis rs1878931 0.726 rs3843728 chr16:3448251 T/C cg22508957 chr16:3507546 NAT15 -0.45 -6.61 -0.38 2.07e-10 Body mass index (adult); CESC cis rs34172651 0.917 rs200536 chr16:24749203 G/A cg06028605 chr16:24865363 SLC5A11 -0.41 -6.16 -0.35 2.66e-9 Intelligence (multi-trait analysis); CESC cis rs7296418 0.599 rs2277343 chr12:123794450 A/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.33 -5.25 -0.31 3.09e-7 Platelet count; CESC cis rs9393777 0.623 rs9358947 chr6:26479000 G/A cg14345882 chr6:26364793 BTN3A2 0.43 5.34 0.31 2.01e-7 Intelligence (multi-trait analysis); CESC cis rs11785400 1.000 rs4518642 chr8:143737396 T/C cg24634471 chr8:143751801 JRK 0.47 6.24 0.36 1.75e-9 Schizophrenia; CESC cis rs11030122 0.702 rs1013351 chr11:3952303 A/T cg18678763 chr11:4115507 RRM1 -0.45 -6.05 -0.35 4.94e-9 Mean platelet volume;Platelet distribution width; CESC cis rs10838687 0.800 rs4752977 chr11:47300429 T/C cg25783544 chr11:47291846 MADD 0.59 6.82 0.39 6.33e-11 Proinsulin levels; CESC cis rs79387448 0.655 rs11891827 chr2:102951182 A/G cg09003973 chr2:102972529 NA 1.06 8.43 0.46 2.21e-15 Gut microbiota (bacterial taxa); CESC cis rs7914558 1.000 rs4917380 chr10:104775335 C/G cg08650961 chr10:104748594 CNNM2 0.33 5.52 0.32 7.94e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17952549 chr19:58983050 ZNF324 -0.71 -7.81 -0.43 1.3e-13 Gut microbiome composition (summer); CESC cis rs863345 0.604 rs4313395 chr1:158505135 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.82 -0.39 6.1e-11 Pneumococcal bacteremia; CESC cis rs10883723 0.810 rs11191304 chr10:104255284 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs6815814 0.950 rs5743794 chr4:38832727 C/T cg02016764 chr4:38805732 TLR1 -0.61 -6.86 -0.39 4.8e-11 Breast cancer; CESC cis rs7267979 1.000 rs1888999 chr20:25291848 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.84 16.39 0.71 3.48e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs2243480 1.000 rs4718316 chr7:65648731 A/G cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.24e-32 Diabetic kidney disease; CESC cis rs710216 0.752 rs841848 chr1:43402545 G/A cg03128534 chr1:43423976 SLC2A1 0.46 5.31 0.31 2.32e-7 Red cell distribution width; CESC trans rs1555543 0.538 rs7416802 chr1:96909292 G/C cg01125333 chr16:2835331 PRSS33 -0.52 -6.15 -0.35 2.86e-9 Body mass index; CESC cis rs9584850 0.574 rs17471079 chr13:99168721 C/T cg20750642 chr13:99100586 FARP1 -0.44 -5.94 -0.34 8.72e-9 Neuroticism; CESC cis rs7827545 1.000 rs7008158 chr8:135565982 T/C cg17885191 chr8:135476712 NA 0.48 6.28 0.36 1.39e-9 Hypertension (SNP x SNP interaction); CESC cis rs10089 1.000 rs2054444 chr5:127493206 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.69 -8.96 -0.48 6.02e-17 Ileal carcinoids; CESC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg18876405 chr7:65276391 NA -0.49 -6.7 -0.38 1.28e-10 Aortic root size; CESC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs2455799 0.613 rs2246960 chr3:15717693 G/A cg16303742 chr3:15540471 COLQ -0.39 -6.03 -0.35 5.51e-9 Mean platelet volume; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg27539627 chr3:122513065 DIRC2;HSPBAP1 0.47 6.1 0.35 3.78e-9 Systemic lupus erythematosus; CESC cis rs6963495 0.799 rs73190201 chr7:105165891 A/C cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg12311346 chr5:56204834 C5orf35 0.4 5.04 0.3 8.68e-7 Coronary artery disease; CESC cis rs1008375 1.000 rs12648232 chr4:17612537 C/T cg02297831 chr4:17616191 MED28 -0.44 -5.4 -0.31 1.47e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2688608 0.592 rs7923045 chr10:75487498 A/T cg23231163 chr10:75533350 FUT11 -0.36 -5.47 -0.32 1.02e-7 Inflammatory bowel disease; CESC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg08736216 chr1:53307985 ZYG11A -0.38 -6.2 -0.36 2.17e-9 Monocyte count; CESC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.898 rs72786270 chr2:24059049 G/A cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.57e-8 Lymphocyte counts; CESC cis rs2243480 0.908 rs55876148 chr7:65379800 G/A cg12463550 chr7:65579703 CRCP 0.71 5.5 0.32 8.79e-8 Diabetic kidney disease; CESC cis rs12824058 0.678 rs11614163 chr12:130814621 C/G cg24838063 chr12:130822603 PIWIL1 0.64 8.21 0.45 9.51e-15 Menopause (age at onset); CESC cis rs6598955 0.671 rs12142535 chr1:26589698 T/A cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg08888203 chr3:10149979 C3orf24 0.5 6.34 0.36 9.96e-10 Alzheimer's disease; CESC cis rs2370759 1.000 rs11008865 chr10:32574842 C/T cg18270830 chr10:32634957 EPC1 0.73 7.28 0.41 3.73e-12 Sexual dysfunction (female); CESC cis rs929354 0.742 rs11980541 chr7:156988776 G/C cg05182265 chr7:156933206 UBE3C -0.51 -7.51 -0.42 9.08e-13 Body mass index; CESC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.41 6.68 0.38 1.37e-10 Personality dimensions; CESC cis rs7000551 0.581 rs2293145 chr8:22262654 A/T cg12081754 chr8:22256438 SLC39A14 0.9 12.57 0.61 1.01e-28 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg17949981 chr6:28129498 ZNF389 0.42 5.1 0.3 6.62e-7 Parkinson's disease; CESC cis rs6460942 0.915 rs75732743 chr7:12454095 C/T cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3796352 1.000 rs71301808 chr3:53085577 C/G cg12962167 chr3:53033115 SFMBT1 0.67 5.91 0.34 1.05e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg25036284 chr2:26402008 FAM59B 0.88 9.99 0.52 3.79e-20 Gut microbiome composition (summer); CESC cis rs7259376 0.714 rs4358065 chr19:22521132 A/G cg02657401 chr19:22469223 NA -0.27 -5.35 -0.31 1.9e-7 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24704015 chr2:230931896 SLC16A14 0.53 6.23 0.36 1.82e-9 Gut microbiome composition (summer); CESC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg11890956 chr21:40555474 PSMG1 -0.65 -9.1 -0.49 2.28e-17 Menarche (age at onset); CESC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.74e-9 Prudent dietary pattern; CESC cis rs9393777 0.623 rs2093169 chr6:26495099 C/T cg12826209 chr6:26865740 GUSBL1 0.66 6.96 0.39 2.61e-11 Intelligence (multi-trait analysis); CESC cis rs7107174 1.000 rs2511177 chr11:77922960 C/T cg27205649 chr11:78285834 NARS2 -0.41 -5.13 -0.3 5.72e-7 Testicular germ cell tumor; CESC cis rs6430585 0.528 rs614193 chr2:136653925 A/T cg07169764 chr2:136633963 MCM6 1.06 15.38 0.69 1.39e-38 Corneal structure; CESC cis rs10752881 0.905 rs12132262 chr1:182989949 T/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.31 0.63 2.66e-31 Colorectal cancer; CESC cis rs2204008 0.775 rs11182513 chr12:38560252 G/C cg13010199 chr12:38710504 ALG10B 0.56 7.18 0.4 7.18e-12 Bladder cancer; CESC cis rs2180341 0.883 rs9388568 chr6:127690694 C/A cg27446573 chr6:127587934 RNF146 1.05 15.58 0.69 2.65e-39 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26186433 chr17:62658397 SMURF2 0.54 6.05 0.35 4.97e-9 Gut microbiome composition (summer); CESC cis rs9581857 0.579 rs9581846 chr13:27987953 A/G cg01674679 chr13:27998804 GTF3A -0.65 -5.18 -0.3 4.41e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs9487051 0.621 rs429534 chr6:109523256 A/G cg01475377 chr6:109611718 NA -0.39 -5.15 -0.3 5.18e-7 Reticulocyte fraction of red cells; CESC cis rs11785400 1.000 rs11780221 chr8:143748215 T/A cg24634471 chr8:143751801 JRK 0.48 6.24 0.36 1.71e-9 Schizophrenia; CESC cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg19912559 chr1:40204330 PPIE 0.42 6.48 0.37 4.37e-10 Blood protein levels; CESC cis rs7824557 0.564 rs6601584 chr8:11232343 C/G cg21775007 chr8:11205619 TDH -0.52 -7.68 -0.43 3.1400000000000003e-13 Retinal vascular caliber; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27247225 chr6:26970382 C6orf41 -0.66 -7.76 -0.43 1.84e-13 Gut microbiome composition (summer); CESC cis rs2742417 0.603 rs2742448 chr3:45764246 C/T cg04837898 chr3:45731254 SACM1L 0.45 5.34 0.31 2.04e-7 Response to anti-depressant treatment in major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11015038 chr20:20349568 INSM1 0.51 6.35 0.36 9.13e-10 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -6.88 -0.39 4.43e-11 Developmental language disorder (linguistic errors); CESC cis rs2228479 0.850 rs17227064 chr16:89816314 A/G cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs2929278 0.546 rs686666 chr15:44161550 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.51 6.5 0.37 4.04e-10 Schizophrenia; CESC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg03467027 chr4:99064603 C4orf37 0.48 6.0 0.35 6.56e-9 Colonoscopy-negative controls vs population controls; CESC cis rs425277 1.000 rs262676 chr1:2078482 T/A cg24578937 chr1:2090814 PRKCZ 0.55 9.54 0.51 9.57e-19 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00167275 chr10:88854588 FAM35A;GLUD1 0.52 6.5 0.37 4.08e-10 Gut microbiome composition (summer); CESC cis rs6504340 0.793 rs12946855 chr17:46608030 G/A cg04904318 chr17:46607828 HOXB1 -0.68 -7.42 -0.41 1.62e-12 Primary tooth development (number of teeth); CESC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg00684032 chr4:1343700 KIAA1530 0.39 5.71 0.33 3.06e-8 Longevity; CESC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg22535103 chr8:58192502 C8orf71 -0.85 -8.38 -0.46 3.08e-15 Developmental language disorder (linguistic errors); CESC cis rs16917546 1.000 rs7090073 chr10:64423505 G/T cg03961010 chr10:64397487 ZNF365 -0.37 -6.14 -0.35 2.97e-9 Basal cell carcinoma; CESC cis rs4253772 0.550 rs6008729 chr22:46727428 C/G cg00784671 chr22:46762841 CELSR1 0.44 5.87 0.34 1.28e-8 LDL cholesterol;Cholesterol, total; CESC cis rs11098499 0.820 rs2389885 chr4:120533931 C/T cg24375607 chr4:120327624 NA 0.46 5.41 0.32 1.38e-7 Corneal astigmatism; CESC cis rs10484885 0.648 rs2777848 chr6:90535993 G/A cg13799429 chr6:90582589 CASP8AP2 -0.88 -11.2 -0.57 4.42e-24 QRS interval (sulfonylurea treatment interaction); CESC cis rs2070677 0.935 rs12256349 chr10:135409632 G/A cg20169779 chr10:135381914 SYCE1 -0.75 -9.82 -0.52 1.26e-19 Gout; CESC cis rs73206853 0.764 rs17682012 chr12:111094454 A/G cg12870014 chr12:110450643 ANKRD13A -0.67 -5.41 -0.32 1.42e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs116095464 1.000 rs28416084 chr5:217640 G/A cg22496380 chr5:211416 CCDC127 -0.96 -10.08 -0.53 1.95e-20 Breast cancer; CESC cis rs6696846 1.000 rs6696846 chr1:205041952 C/T cg00857998 chr1:205179979 DSTYK 0.52 7.09 0.4 1.22e-11 Red blood cell count; CESC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg11663144 chr21:46675770 NA -0.51 -7.13 -0.4 9.49e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg24060327 chr5:131705240 SLC22A5 0.76 10.49 0.54 8.94e-22 Acylcarnitine levels; CESC cis rs8022179 0.580 rs6575979 chr14:103841018 A/G cg12935359 chr14:103987150 CKB -0.48 -6.2 -0.36 2.13e-9 Monocyte count; CESC cis rs8064299 0.597 rs4789098 chr17:72781292 C/G cg25054828 chr17:72772726 NAT9;TMEM104 0.77 12.37 0.61 4.66e-28 Monocyte count; CESC cis rs1570884 0.516 rs9316462 chr13:50176321 A/G cg03651054 chr13:50194643 NA 0.31 5.1 0.3 6.6e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs7202877 0.610 rs468079 chr16:75428474 G/A cg04384234 chr16:75411784 CFDP1 0.47 5.82 0.34 1.71e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg17143192 chr8:8559678 CLDN23 -0.45 -5.58 -0.32 6.02e-8 Mood instability; CESC cis rs7666738 0.715 rs61114099 chr4:98931270 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19022780 chr9:134378720 POMT1 -0.62 -6.92 -0.39 3.38e-11 Gut microbiome composition (summer); CESC cis rs748404 0.631 rs4296223 chr15:43645246 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.52 0.46 1.2e-15 Lung cancer; CESC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg23281280 chr6:28129359 ZNF389 0.56 7.61 0.42 4.91e-13 Depression; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24816464 chr3:86061715 CADM2 -0.45 -6.14 -0.35 2.93e-9 Asthma; CESC cis rs3806843 0.735 rs2563333 chr5:140052271 A/G cg16179182 chr5:140090404 VTRNA1-1 0.37 5.05 0.3 8.31e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2882667 0.929 rs34846849 chr5:138360578 T/C cg04439458 chr5:138467593 SIL1 -0.39 -6.14 -0.35 2.98e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1018836 0.923 rs12545279 chr8:91636373 C/G cg16814680 chr8:91681699 NA -0.72 -10.37 -0.54 2.32e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs897984 0.520 rs4889536 chr16:30871755 G/T cg02466173 chr16:30829666 NA 0.48 6.88 0.39 4.33e-11 Dementia with Lewy bodies; CESC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.14 0.4 8.89e-12 Height; CESC cis rs2070488 0.804 rs2276541 chr3:38512779 G/A cg24069376 chr3:38537580 EXOG 0.35 6.04 0.35 5.11e-9 Electrocardiographic conduction measures; CESC cis rs7208859 0.524 rs59913838 chr17:29101563 A/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3106136 0.546 rs4693003 chr4:95145469 A/G cg11021082 chr4:95130006 SMARCAD1 -0.69 -11.19 -0.57 4.77e-24 Capecitabine sensitivity; CESC cis rs12530845 0.943 rs11984203 chr7:135325947 C/T cg23117316 chr7:135346802 PL-5283 0.46 5.64 0.33 4.43e-8 Red blood cell traits; CESC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg09877947 chr5:131593287 PDLIM4 0.52 6.87 0.39 4.47e-11 Acylcarnitine levels; CESC cis rs6915183 1.000 rs6915183 chr6:166706169 C/T cg14022523 chr6:166756177 SFT2D1 -0.58 -7.79 -0.43 1.48e-13 Longevity; CESC cis rs116095464 0.558 rs28558836 chr5:285748 C/G cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.27 0.31 2.84e-7 Breast cancer; CESC cis rs116095464 0.558 rs62346526 chr5:220614 T/C cg22496380 chr5:211416 CCDC127 -0.72 -8.57 -0.47 8.59e-16 Breast cancer; CESC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Parkinson's disease; CESC cis rs10493773 0.566 rs11161659 chr1:86183967 T/C cg17807903 chr1:86174739 ZNHIT6 -0.44 -6.53 -0.37 3.43e-10 Urate levels in overweight individuals; CESC cis rs6582630 0.576 rs4882258 chr12:38453686 C/T cg26384229 chr12:38710491 ALG10B -0.44 -5.92 -0.34 9.96e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs10754283 1.000 rs10754283 chr1:90112431 G/T cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs13631 0.965 rs7853589 chr9:140003844 A/G cg14289826 chr9:140003911 NA -0.37 -6.97 -0.39 2.53e-11 Cerebrospinal fluid biomarker levels; CESC cis rs4237845 0.804 rs10877034 chr12:58286444 T/C cg02175503 chr12:58329896 NA 0.55 7.29 0.41 3.55e-12 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26547359 chr10:16859530 RSU1 0.45 6.14 0.35 2.94e-9 Gut microbiota (bacterial taxa); CESC cis rs1865760 0.555 rs2051541 chr6:25945211 C/T cg16482183 chr6:26056742 HIST1H1C -0.42 -5.56 -0.32 6.71e-8 Height; CESC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg25405998 chr7:65216604 CCT6P1 0.46 5.14 0.3 5.31e-7 Aortic root size; CESC cis rs1046896 1.000 rs1046917 chr17:80685655 A/G cg02711726 chr17:80685570 FN3KRP 0.6 9.04 0.49 3.37e-17 Glycated hemoglobin levels; CESC cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg18225595 chr11:63971243 STIP1 0.74 10.31 0.53 3.67e-21 Platelet count; CESC cis rs2730245 1.000 rs6965685 chr7:158726462 C/T cg15303052 chr7:158526867 ESYT2 -0.43 -5.25 -0.31 3.2e-7 Height; CESC cis rs9303401 0.661 rs9902820 chr17:56637545 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.54 7.24 0.41 4.92e-12 Cognitive test performance; CESC trans rs9325144 0.647 rs7487395 chr12:38865660 C/A cg10679878 chr6:156759499 NA -0.33 -6.0 -0.35 6.61e-9 Morning vs. evening chronotype; CESC cis rs3540 0.574 rs2256388 chr15:90969335 A/C cg22089800 chr15:90895588 ZNF774 -0.61 -8.36 -0.46 3.69e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs10744422 1.000 rs921808 chr12:123323135 A/G cg25930673 chr12:123319894 HIP1R 0.65 5.28 0.31 2.72e-7 Schizophrenia; CESC cis rs920590 0.758 rs1826420 chr8:19664878 G/T cg03894339 chr8:19674705 INTS10 0.62 7.33 0.41 2.83e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg14393609 chr7:65229607 NA 0.52 7.08 0.4 1.33e-11 Calcium levels; CESC cis rs2880765 0.835 rs7169632 chr15:86044667 T/G cg19183879 chr15:85880815 NA -0.26 -5.29 -0.31 2.52e-7 Coronary artery disease; CESC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.92 9.76 0.51 2.07e-19 Platelet count; CESC cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.42 -0.32 1.37e-7 Developmental language disorder (linguistic errors); CESC cis rs34779708 0.966 rs878264 chr10:35440581 T/C cg03585969 chr10:35415529 CREM 0.74 10.0 0.52 3.6e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -6.63 -0.38 1.89e-10 Bipolar disorder; CESC cis rs9399137 0.507 rs11154791 chr6:135379148 A/G cg24558204 chr6:135376177 HBS1L 0.69 9.53 0.51 1.08e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs28647808 0.786 rs28649804 chr9:136257709 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs892961 0.806 rs35489990 chr17:75412312 T/C cg05865280 chr17:75406074 SEPT9 0.62 12.68 0.61 4.16e-29 Airflow obstruction; CESC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg23131131 chr22:24373011 LOC391322 -0.68 -8.98 -0.48 5.01e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs950169 0.724 rs11632668 chr15:84948687 T/C cg17507749 chr15:85114479 UBE2QP1 0.59 6.52 0.37 3.46e-10 Schizophrenia; CESC cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg26597838 chr10:835615 NA 1.2 12.13 0.6 3.18e-27 Eosinophil percentage of granulocytes; CESC cis rs4746818 1.000 rs9299502 chr10:70876934 C/T cg04149295 chr10:70884716 VPS26A 0.63 6.7 0.38 1.27e-10 Left atrial antero-posterior diameter; CESC cis rs2522056 1.000 rs10900807 chr5:131757480 G/C cg24060327 chr5:131705240 SLC22A5 0.69 7.73 0.43 2.27e-13 Lymphocyte counts;Fibrinogen; CESC cis rs2153904 0.793 rs71633563 chr1:205735854 C/T cg23034840 chr1:205782522 SLC41A1 -0.65 -6.44 -0.37 5.68e-10 Prostate-specific antigen levels; CESC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg08632164 chr7:65971372 NA 0.32 5.14 0.3 5.29e-7 Aortic root size; CESC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg25036284 chr2:26402008 FAM59B -0.86 -9.35 -0.5 3.8e-18 Gut microbiome composition (summer); CESC cis rs4474465 0.646 rs10899556 chr11:78278986 C/T cg27205649 chr11:78285834 NARS2 0.48 6.26 0.36 1.51e-9 Alzheimer's disease (survival time); CESC cis rs7208859 0.623 rs8080882 chr17:29081146 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2806561 0.577 rs488438 chr1:23498999 T/A cg12483005 chr1:23474871 LUZP1 0.39 6.16 0.35 2.68e-9 Height; CESC cis rs1371867 0.875 rs1371868 chr8:101330267 C/T cg11906718 chr8:101322791 RNF19A 0.53 6.89 0.39 4.16e-11 Atrioventricular conduction; CESC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg19592336 chr6:28129416 ZNF389 0.57 7.34 0.41 2.64e-12 Parkinson's disease; CESC cis rs3820928 0.874 rs13383070 chr2:227904939 C/T cg11843606 chr2:227700838 RHBDD1 -0.49 -6.71 -0.38 1.18e-10 Pulmonary function; CESC cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg03467027 chr4:99064603 C4orf37 0.48 6.02 0.35 5.66e-9 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.863 rs2127823 chr4:120485670 G/T cg24375607 chr4:120327624 NA 0.43 5.23 0.31 3.44e-7 Corneal astigmatism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16427743 chr14:65210080 PLEKHG3 0.45 6.2 0.36 2.2e-9 Fibrinogen levels; CESC cis rs4555082 1.000 rs4555082 chr14:105758964 C/T cg13114125 chr14:105738426 BRF1 -0.75 -9.55 -0.51 8.88e-19 Mean platelet volume;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14126493 chr5:176831297 F12 0.59 6.45 0.37 5.25e-10 Gut microbiome composition (summer); CESC cis rs765787 0.530 rs4774542 chr15:45526026 A/C cg24006582 chr15:45444508 DUOX1 0.53 6.21 0.36 2.07e-9 Uric acid levels; CESC cis rs9325144 0.560 rs2387924 chr12:38662883 A/G cg13010199 chr12:38710504 ALG10B -0.45 -6.1 -0.35 3.79e-9 Morning vs. evening chronotype; CESC trans rs4756846 1.000 rs17554301 chr11:16402082 C/T cg05579622 chr5:10618622 ANKRD33B 0.76 6.93 0.39 3.14e-11 Obesity and osteoporosis; CESC cis rs941873 0.868 rs1483733 chr10:81130036 A/G cg08514558 chr10:81106712 PPIF 0.32 5.77 0.33 2.26e-8 Height; CESC cis rs4718428 0.672 rs13241598 chr7:66300652 A/G cg06064049 chr7:66057363 NA 0.49 5.07 0.3 7.54e-7 Corneal structure; CESC cis rs763121 0.819 rs8137829 chr22:39061030 G/A cg21395723 chr22:39101663 GTPBP1 0.43 5.37 0.31 1.74e-7 Menopause (age at onset); CESC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs10845606 1.000 rs10845610 chr12:12839107 G/A cg09462578 chr12:12878428 APOLD1 -0.66 -7.25 -0.41 4.57e-12 Systemic lupus erythematosus; CESC cis rs72781680 0.904 rs72796340 chr2:24143622 T/A cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg11764359 chr7:65958608 NA 0.83 9.53 0.51 1.09e-18 Aortic root size; CESC cis rs4822044 0.561 rs132781 chr22:42046122 T/G cg03806693 chr22:41940476 POLR3H 1.04 12.04 0.59 6.41e-27 Cannabis dependence symptom count; CESC cis rs7809950 0.817 rs2237671 chr7:107131528 A/T cg23024343 chr7:107201750 COG5 -0.58 -7.47 -0.42 1.18e-12 Coronary artery disease; CESC cis rs1348850 0.609 rs1348851 chr2:178418677 C/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.66 -5.63 -0.33 4.7e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1475911 0.708 rs56109792 chr21:43520060 A/G cg03240473 chr21:43526662 UMODL1;C21orf128 -0.5 -6.63 -0.38 1.85e-10 IgG glycosylation; CESC cis rs6762 0.550 rs8672 chr11:838634 C/G cg16425592 chr11:842748 TSPAN4;POLR2L -0.74 -9.96 -0.52 4.73e-20 Mean platelet volume; CESC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg03647317 chr4:187891568 NA -0.39 -5.79 -0.34 1.98e-8 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26568855 chr1:155145228 TRIM46;KRTCAP2 0.6 6.59 0.38 2.36e-10 Gut microbiome composition (summer); CESC cis rs6546550 0.935 rs1377995 chr2:70064155 C/G cg02498382 chr2:70120550 SNRNP27 -0.39 -6.7 -0.38 1.23e-10 Prevalent atrial fibrillation; CESC cis rs5997397 0.967 rs5752791 chr22:29153547 A/G cg02153584 chr22:29168773 CCDC117 -0.52 -7.13 -0.4 9.38e-12 Red cell distribution width; CESC cis rs1538970 0.816 rs61788356 chr1:46006675 C/T cg06784218 chr1:46089804 CCDC17 0.35 5.62 0.33 4.81e-8 Platelet count; CESC cis rs11602339 1 rs11602339 chr11:47761471 C/T cg20307385 chr11:47447363 PSMC3 -0.52 -6.37 -0.36 8.3e-10 Body mass index; CESC cis rs989128 0.600 rs8082568 chr17:48629312 G/C cg24438145 chr17:48624694 SPATA20 0.45 5.31 0.31 2.36e-7 Type 2 diabetes; CESC cis rs11252926 0.801 rs11252332 chr10:467318 A/T cg08603382 chr10:743973 NA 0.52 6.56 0.37 2.87e-10 Psychosis in Alzheimer's disease; CESC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg18758796 chr5:131593413 PDLIM4 0.46 6.62 0.38 1.96e-10 Breast cancer; CESC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg18876405 chr7:65276391 NA 0.48 5.59 0.33 5.5e-8 Aortic root size; CESC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg13206674 chr6:150067644 NUP43 0.43 6.22 0.36 1.95e-9 Lung cancer; CESC cis rs7592578 0.771 rs75579212 chr2:191376575 C/T cg10560079 chr2:191398806 TMEM194B -0.69 -6.12 -0.35 3.37e-9 Diastolic blood pressure; CESC cis rs10426930 0.700 rs7253212 chr19:5021391 G/A cg18115693 chr19:4968519 KDM4B -0.41 -5.19 -0.3 4.1e-7 Monocyte percentage of white cells; CESC cis rs7659604 0.502 rs28435300 chr4:122709412 T/C cg19748678 chr4:122722346 EXOSC9 -0.42 -5.26 -0.31 2.97e-7 Type 2 diabetes; CESC cis rs7937682 0.847 rs583032 chr11:111432757 C/T cg22437258 chr11:111473054 SIK2 0.76 9.93 0.52 5.87e-20 Primary sclerosing cholangitis; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg15046927 chr5:170863172 FGF18 0.4 6.24 0.36 1.75e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs6089829 0.962 rs6062776 chr20:61663736 A/G cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs2207136 0.868 rs2857487 chr6:50793671 A/G cg06522515 chr3:184090630 THPO 0.36 6.11 0.35 3.61e-9 Myopia; CESC cis rs3820068 0.554 rs60233444 chr1:15921330 A/C cg13390004 chr1:15929781 NA 0.33 5.04 0.3 8.45e-7 Systolic blood pressure; CESC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg18904891 chr8:8559673 CLDN23 0.67 7.49 0.42 1.01e-12 Obesity-related traits; CESC trans rs1814175 0.817 rs7947526 chr11:49983654 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -20.41 -0.78 2.63e-56 Height; CESC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg23172400 chr8:95962367 TP53INP1 -0.46 -9.8 -0.52 1.55e-19 Type 2 diabetes; CESC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg24549020 chr5:56110836 MAP3K1 0.56 5.32 0.31 2.2e-7 Type 2 diabetes; CESC cis rs2933343 0.661 rs2630259 chr3:128606322 C/T cg24203234 chr3:128598194 ACAD9 0.43 5.79 0.34 1.97e-8 IgG glycosylation; CESC cis rs6088590 1.000 rs6119524 chr20:33373813 C/T cg08999081 chr20:33150536 PIGU 0.58 8.9 0.48 9.32e-17 Coronary artery disease; CESC cis rs7648466 0.544 rs2172247 chr3:46214670 T/C cg19145607 chr3:45983792 CXCR6;FYCO1 0.35 5.42 0.32 1.34e-7 Eotaxin levels; CESC cis rs6912958 0.684 rs2787893 chr6:88387359 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -5.85 -0.34 1.48e-8 Monocyte percentage of white cells; CESC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs12995491 0.933 rs34029976 chr2:88537797 T/C cg07952391 chr2:88470173 THNSL2 -0.55 -8.4 -0.46 2.72e-15 Response to metformin (IC50); CESC cis rs8020095 0.571 rs7493580 chr14:67580450 T/A cg19548862 chr14:67692701 FAM71D -0.49 -5.88 -0.34 1.23e-8 Depression (quantitative trait); CESC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg01238044 chr22:24384105 GSTT1 -0.58 -7.53 -0.42 7.74e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs826838 0.967 rs7136593 chr12:39128265 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.51 0.37 3.66e-10 Bipolar disorder; CESC cis rs9300255 0.739 rs6633 chr12:123745809 G/T cg00376283 chr12:123451042 ABCB9 -0.63 -6.54 -0.37 3.21e-10 Neutrophil percentage of white cells; CESC cis rs2204008 0.677 rs1581356 chr12:38391467 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.91 0.52 6.67e-20 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18171715 chr4:852160 GAK -0.6 -6.39 -0.37 7.33e-10 Gut microbiome composition (summer); CESC cis rs1559088 0.948 rs12608825 chr19:33581219 C/T cg03563238 chr19:33554763 RHPN2 0.29 5.05 0.3 8.39e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs17376456 0.877 rs10066791 chr5:93350255 G/T cg25358565 chr5:93447407 FAM172A 1.05 10.09 0.53 1.77e-20 Diabetic retinopathy; CESC cis rs4975616 0.869 rs380286 chr5:1320247 G/A cg06550200 chr5:1325588 CLPTM1L -0.7 -10.91 -0.56 3.78e-23 Lung cancer; CESC cis rs2882667 0.931 rs10074461 chr5:138319815 G/T cg04439458 chr5:138467593 SIL1 -0.29 -5.1 -0.3 6.58e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs870825 0.616 rs6552804 chr4:185637699 A/G cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs2073300 0.609 rs17830281 chr20:23350525 C/T cg12062639 chr20:23401060 NAPB 0.98 7.59 0.42 5.37e-13 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21831501 chr1:173446253 PRDX6 0.55 6.14 0.35 3.05e-9 Gut microbiome composition (summer); CESC cis rs910316 1.000 rs28626045 chr14:75589195 G/C cg11812906 chr14:75593930 NEK9 0.89 15.12 0.68 1.11e-37 Height; CESC cis rs9402673 0.558 rs9688342 chr6:135323026 A/T cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Reticulocyte count;High light scatter reticulocyte count; CESC cis rs2455799 0.573 rs62243672 chr3:15937200 C/T cg16303742 chr3:15540471 COLQ -0.35 -5.27 -0.31 2.79e-7 Mean platelet volume; CESC cis rs3733585 0.805 rs882222 chr4:9981294 G/A cg02734326 chr4:10020555 SLC2A9 0.46 6.9 0.39 3.73e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs722599 0.562 rs2287400 chr14:75182937 G/A cg08847533 chr14:75593920 NEK9 0.44 5.32 0.31 2.22e-7 IgG glycosylation; CESC cis rs73058052 0.867 rs57940349 chr19:50097607 C/T cg09250473 chr19:50168907 IRF3;BCL2L12 0.6 5.29 0.31 2.56e-7 Fibrinogen levels; CESC cis rs10771431 0.597 rs10843144 chr12:9357577 C/T cg08997352 chr12:9597637 DDX12 -0.72 -8.96 -0.48 5.74e-17 Breast size; CESC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg23978390 chr7:1156363 C7orf50 0.57 5.85 0.34 1.45e-8 Bronchopulmonary dysplasia; CESC cis rs1568889 0.838 rs11030206 chr11:28099747 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 13.5 0.64 5.59e-32 Bipolar disorder; CESC cis rs67311347 1.000 rs2085115 chr3:40497540 G/T cg09455208 chr3:40491958 NA 0.51 8.15 0.45 1.43e-14 Renal cell carcinoma; CESC cis rs2439831 0.702 rs8033995 chr15:44013509 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.67 6.32 0.36 1.13e-9 Lung cancer in ever smokers; CESC cis rs8044868 0.586 rs3844425 chr16:72194325 T/C cg01557791 chr16:72042693 DHODH -0.4 -5.37 -0.31 1.71e-7 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg14926445 chr8:58193284 C8orf71 -0.52 -5.53 -0.32 7.54e-8 Developmental language disorder (linguistic errors); CESC cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg10523679 chr1:76189770 ACADM 0.73 8.57 0.47 8.98e-16 Blood metabolite levels;Acylcarnitine levels; CESC cis rs17818399 0.712 rs13008088 chr2:46781580 C/G cg06386533 chr2:46925753 SOCS5 0.46 5.45 0.32 1.17e-7 Height; CESC trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.44 -0.46 2.11e-15 Intelligence (multi-trait analysis); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg21194723 chr11:60681294 TMEM109 -0.46 -6.13 -0.35 3.19e-9 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23162967 chr3:105587981 CBLB -0.41 -6.04 -0.35 5.17e-9 Gambling; CESC cis rs6912958 0.781 rs2268993 chr6:88184111 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -5.82 -0.34 1.68e-8 Monocyte percentage of white cells; CESC cis rs3806843 1.000 rs2240695 chr5:140168151 G/T cg26395211 chr5:140044315 WDR55 -0.43 -5.52 -0.32 8.02e-8 Depressive symptoms (multi-trait analysis); CESC cis rs854765 0.562 rs2955381 chr17:17945500 G/C cg09796270 chr17:17721594 SREBF1 -0.38 -5.07 -0.3 7.66e-7 Total body bone mineral density; CESC cis rs7107174 1.000 rs57738705 chr11:77994489 A/G cg02023728 chr11:77925099 USP35 0.48 6.64 0.38 1.74e-10 Testicular germ cell tumor; CESC cis rs6674176 0.597 rs12127737 chr1:44402565 G/A cg23954153 chr1:44402353 ARTN -0.37 -5.94 -0.34 8.99e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4950322 0.570 rs72691095 chr1:146769990 G/C cg22381352 chr1:146742008 CHD1L -0.46 -5.05 -0.3 8.32e-7 Protein quantitative trait loci; CESC cis rs2932538 0.845 rs6682678 chr1:113206920 A/G cg22162597 chr1:113214053 CAPZA1 -0.56 -7.04 -0.4 1.66e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs2712184 0.967 rs1014680 chr2:217672824 A/G cg05032264 chr2:217675019 NA 0.38 5.54 0.32 7.31e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC cis rs2108622 0.683 rs111388185 chr19:15977414 T/C cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23282051 chr2:239067613 NA 0.56 6.62 0.38 2.04e-10 Gut microbiome composition (summer); CESC cis rs8014204 0.901 rs6574200 chr14:75364451 C/T cg26191576 chr14:75389716 RPS6KL1 0.36 5.13 0.3 5.56e-7 Caffeine consumption; CESC cis rs9581857 0.615 rs79553479 chr13:28007862 G/A cg22138327 chr13:27999177 GTF3A 0.66 5.32 0.31 2.17e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs7607369 0.714 rs1344643 chr2:219584975 G/C cg02176678 chr2:219576539 TTLL4 -0.49 -8.7 -0.47 3.47e-16 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs7914558 1.000 rs10509757 chr10:104752960 C/T cg04362960 chr10:104952993 NT5C2 0.48 6.42 0.37 6.23e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs10751667 0.621 rs10794353 chr11:948740 A/G cg20946044 chr11:1010712 AP2A2 -0.4 -5.52 -0.32 8.07e-8 Alzheimer's disease (late onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14265927 chr9:139137836 QSOX2 -0.41 -6.08 -0.35 4.1e-9 Gambling; CESC cis rs6141600 0.540 rs1006296 chr20:34717718 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -5.94 -0.34 8.97e-9 Height;Hip circumference; CESC cis rs17376456 0.757 rs1031424 chr5:93139706 G/C cg21475434 chr5:93447410 FAM172A 0.83 7.39 0.41 1.91e-12 Diabetic retinopathy; CESC cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.49 6.26 0.36 1.5e-9 Tonsillectomy; CESC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg17747265 chr1:1875780 NA -0.57 -9.24 -0.49 8.4e-18 Body mass index; CESC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg25767906 chr1:53392781 SCP2 -0.5 -7.07 -0.4 1.39e-11 Monocyte count; CESC cis rs1707322 0.721 rs10890344 chr1:46166090 C/T cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs916888 0.773 rs1378358 chr17:44787312 C/T cg01570182 chr17:44337453 NA 0.94 10.63 0.55 3.24e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6580649 0.941 rs11612578 chr12:48414798 T/C cg05342945 chr12:48394962 COL2A1 0.49 5.52 0.32 8.21e-8 Lung cancer; CESC cis rs7089973 0.604 rs7095816 chr10:116585109 T/C cg03647239 chr10:116582469 FAM160B1 0.45 5.77 0.33 2.19e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg10819733 chr22:24237672 NA -0.47 -6.76 -0.38 8.96e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7481584 0.646 rs434114 chr11:3050210 A/G cg25174290 chr11:3078921 CARS -0.45 -6.28 -0.36 1.36e-9 Calcium levels; CESC cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg27478167 chr7:817139 HEATR2 -0.5 -5.91 -0.34 1.06e-8 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14908186 chr13:113863106 CUL4A;PCID2 0.51 6.12 0.35 3.32e-9 Gut microbiome composition (summer); CESC cis rs8040855 0.627 rs12904238 chr15:85639841 A/T cg08123816 chr15:85640762 PDE8A -0.41 -6.19 -0.36 2.33e-9 Bulimia nervosa; CESC cis rs2996428 0.629 rs12135894 chr1:3728061 C/T cg13057898 chr1:3703894 LRRC47 0.46 6.33 0.36 1.06e-9 Red cell distribution width; CESC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg18404041 chr3:52824283 ITIH1 -0.39 -6.56 -0.37 2.86e-10 Bipolar disorder; CESC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.34 0.63 2.04e-31 Prudent dietary pattern; CESC trans rs7839040 0.698 rs2048105 chr8:82931756 C/T cg14472086 chr9:107730925 NA -0.48 -6.45 -0.37 5.4e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg11062466 chr8:58055876 NA 0.45 6.04 0.35 5.28e-9 Developmental language disorder (linguistic errors); CESC trans rs1814175 0.592 rs1794161 chr11:49898825 A/C cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.51e-9 Height; CESC cis rs6842047 0.706 rs4862667 chr4:187136416 A/G cg23442198 chr4:187126114 CYP4V2 0.64 5.41 0.32 1.38e-7 Blood protein levels; CESC cis rs9584850 0.834 rs7985565 chr13:99113471 C/G cg22223119 chr13:99095684 FARP1 -0.35 -5.17 -0.3 4.55e-7 Neuroticism; CESC trans rs11098499 0.955 rs1551 chr4:120158500 T/G cg25214090 chr10:38739885 LOC399744 0.64 8.63 0.47 5.92e-16 Corneal astigmatism; CESC cis rs6120849 0.901 rs6058193 chr20:33734464 A/G cg24642439 chr20:33292090 TP53INP2 0.64 6.77 0.38 8.31e-11 Protein C levels; CESC cis rs28374715 0.681 rs11629979 chr15:41626579 A/G cg18705301 chr15:41695430 NDUFAF1 -0.78 -11.24 -0.57 3.19e-24 Ulcerative colitis; CESC trans rs61931739 0.534 rs10844725 chr12:34009504 C/A cg26384229 chr12:38710491 ALG10B 0.59 8.19 0.45 1.11e-14 Morning vs. evening chronotype; CESC cis rs2235642 0.928 rs9932984 chr16:1605051 A/G cg09080909 chr16:1797204 MAPK8IP3 -0.36 -5.06 -0.3 7.83e-7 Coronary artery disease; CESC cis rs3749237 0.964 rs13084243 chr3:49821878 G/C cg03060546 chr3:49711283 APEH 0.66 7.88 0.44 8.24e-14 Resting heart rate; CESC cis rs57221529 0.709 rs72707023 chr5:667620 G/A cg09021430 chr5:549028 NA -0.43 -5.15 -0.3 5.21e-7 Lung disease severity in cystic fibrosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.15.1220700F chr15:75682336 SIN3A -0.54 -6.29 -0.36 1.31e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27370461 chr11:111637044 PPP2R1B 0.6 7.18 0.4 7.19e-12 Gut microbiome composition (summer); CESC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg13393036 chr8:95962371 TP53INP1 -0.5 -10.81 -0.55 8.43e-23 Type 2 diabetes; CESC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg18876405 chr7:65276391 NA 0.56 7.49 0.42 1e-12 Aortic root size; CESC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg02951883 chr7:2050386 MAD1L1 -0.51 -6.79 -0.39 7.2e-11 Bipolar disorder and schizophrenia; CESC cis rs4319547 1.000 rs6489156 chr12:123100397 C/T cg05707623 chr12:122985044 ZCCHC8 -0.59 -7.11 -0.4 1.07e-11 Body mass index; CESC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg06634786 chr22:41940651 POLR3H 0.68 6.72 0.38 1.13e-10 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22855052 chr12:6982535 SPSB2 0.58 6.81 0.39 6.34e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22954621 chr10:13514626 BEND7 -0.62 -7.6 -0.42 5.23e-13 Gut microbiome composition (summer); CESC cis rs2204008 0.575 rs10444564 chr12:38043782 T/C cg13010199 chr12:38710504 ALG10B 0.54 6.63 0.38 1.87e-10 Bladder cancer; CESC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg17340268 chr14:105411764 AHNAK2 -0.52 -6.92 -0.39 3.36e-11 Rheumatoid arthritis; CESC cis rs12477438 0.520 rs2309581 chr2:99784292 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.89 -15.68 -0.69 1.15e-39 Chronic sinus infection; CESC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg04166393 chr7:2884313 GNA12 0.61 8.24 0.45 8.02e-15 Height; CESC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg03388025 chr16:89894329 SPIRE2 0.39 7.71 0.43 2.58e-13 Vitiligo; CESC cis rs34779708 0.931 rs11010132 chr10:35517265 C/G cg03585969 chr10:35415529 CREM 0.68 8.52 0.46 1.23e-15 Inflammatory bowel disease;Crohn's disease; CESC cis rs6540559 0.546 rs634601 chr1:210421594 C/T cg23283495 chr1:209979779 IRF6 0.42 5.53 0.32 7.75e-8 Cleft lip with or without cleft palate; CESC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg11905131 chr22:24372483 LOC391322 0.68 9.74 0.51 2.36e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9796 0.870 rs10851402 chr15:41263438 C/T cg18705301 chr15:41695430 NDUFAF1 0.4 5.73 0.33 2.73e-8 Menopause (age at onset); CESC cis rs7927771 0.524 rs10742824 chr11:47864842 C/T cg18512352 chr11:47633146 NA 0.35 5.37 0.31 1.7e-7 Subjective well-being; CESC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg24549020 chr5:56110836 MAP3K1 -0.48 -5.84 -0.34 1.55e-8 Initial pursuit acceleration; CESC cis rs11039389 1 rs11039389 chr11:47796062 T/C cg18512352 chr11:47633146 NA -0.6 -9.52 -0.5 1.17e-18 Neuroticism; CESC cis rs1018836 0.892 rs4735210 chr8:91549399 G/T cg16814680 chr8:91681699 NA -0.62 -8.84 -0.48 1.38e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7914558 1.000 rs3740387 chr10:104849468 G/A cg04362960 chr10:104952993 NT5C2 0.47 6.18 0.35 2.42e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9486719 0.895 rs3734239 chr6:96996244 A/G cg18709589 chr6:96969512 KIAA0776 -0.52 -5.69 -0.33 3.43e-8 Migraine;Coronary artery disease; CESC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.99e-8 Eye color traits; CESC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg15813090 chr5:442598 EXOC3;C5orf55 0.41 6.22 0.36 1.89e-9 Cystic fibrosis severity; CESC trans rs9388451 0.626 rs7748729 chr6:126077381 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.65 -9.14 -0.49 1.67e-17 Brugada syndrome; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11636702 chr4:11370466 MIR572 0.43 6.36 0.36 8.56e-10 Fibrinogen levels; CESC cis rs2455799 0.613 rs2470547 chr3:15737610 T/C cg09340198 chr3:15902540 ANKRD28 -0.32 -5.11 -0.3 6.05e-7 Mean platelet volume; CESC cis rs2050392 0.792 rs303434 chr10:30714440 G/A cg18806716 chr10:30721971 MAP3K8 -0.4 -5.79 -0.33 2.02e-8 Inflammatory bowel disease; CESC cis rs1707322 0.929 rs785500 chr1:46593044 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.63 -0.33 4.67e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8057939 0.593 rs12597275 chr16:49419305 C/T cg15532236 chr6:170188124 NA 0.5 6.1 0.35 3.83e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9400271 0.632 rs9374072 chr6:109591586 A/G cg01475377 chr6:109611718 NA -0.45 -7.02 -0.4 1.9e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs2950393 0.857 rs1563896 chr12:57093096 A/G cg05584118 chr12:57595605 LRP1 -0.37 -5.04 -0.3 8.83e-7 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23167218 chr5:138609385 MATR3;SNHG4 0.52 6.27 0.36 1.43e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06604058 chr11:63448992 RTN3 -0.44 -6.33 -0.36 1.03e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg00339695 chr16:24857497 SLC5A11 0.49 6.06 0.35 4.56e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg05863683 chr7:1912471 MAD1L1 0.37 5.56 0.32 6.65e-8 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23058863 chr14:24610866 FAM158A -0.43 -6.04 -0.35 5.18e-9 Gambling; CESC cis rs3733585 0.673 rs4519796 chr4:9955936 A/G cg11266682 chr4:10021025 SLC2A9 -0.57 -10.92 -0.56 3.75e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2880765 0.835 rs11856869 chr15:86029097 C/G cg10818794 chr15:86012489 AKAP13 -0.34 -5.24 -0.31 3.26e-7 Coronary artery disease; CESC cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg19077165 chr18:44547161 KATNAL2 0.51 7.06 0.4 1.45e-11 Personality dimensions; CESC cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg18180107 chr4:99064573 C4orf37 0.45 5.71 0.33 3.05e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4595586 0.545 rs12823586 chr12:39391677 C/G cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02580404 chr16:19729857 C16orf88;IQCK -0.44 -6.09 -0.35 3.91e-9 Fibrinogen levels; CESC cis rs9905704 0.633 rs2526368 chr17:56470310 G/T cg12560992 chr17:57184187 TRIM37 -0.61 -5.75 -0.33 2.49e-8 Testicular germ cell tumor; CESC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2109514 0.967 rs10271007 chr7:116145849 A/G cg12739419 chr7:116140593 CAV2 -0.35 -6.48 -0.37 4.44e-10 Prevalent atrial fibrillation; CESC cis rs258892 0.895 rs155433 chr5:72139664 G/C cg21869765 chr5:72125136 TNPO1 0.44 5.48 0.32 9.83e-8 Small cell lung carcinoma; CESC cis rs6987853 0.787 rs2974309 chr8:42426961 G/A cg09913449 chr8:42400586 C8orf40 0.47 7.86 0.43 9.71e-14 Mean corpuscular hemoglobin concentration; CESC cis rs7666738 0.791 rs11097610 chr4:99011795 C/G cg05340658 chr4:99064831 C4orf37 0.79 11.98 0.59 1.05e-26 Colonoscopy-negative controls vs population controls; CESC cis rs2273669 0.588 rs78276890 chr6:109305299 G/A cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC cis rs763121 0.853 rs5757234 chr22:39072686 C/T cg14440974 chr22:39074834 NA -0.36 -5.21 -0.3 3.78e-7 Menopause (age at onset); CESC cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg21644426 chr2:191273491 MFSD6 0.48 6.41 0.37 6.5e-10 Pulse pressure; CESC cis rs7267979 1.000 rs2424704 chr20:25273929 A/G cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7208859 0.623 rs76633166 chr17:29113365 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg12412775 chr1:25698385 RHCE 0.32 5.69 0.33 3.29e-8 Erythrocyte sedimentation rate; CESC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg11764359 chr7:65958608 NA -0.72 -9.54 -0.51 9.82e-19 Aortic root size; CESC cis rs7829975 0.508 rs4841006 chr8:8501474 T/C cg06636001 chr8:8085503 FLJ10661 -0.41 -5.4 -0.31 1.48e-7 Mood instability; CESC cis rs7927771 0.524 rs12286721 chr11:47701528 G/T cg20307385 chr11:47447363 PSMC3 -0.58 -8.03 -0.44 3.18e-14 Subjective well-being; CESC cis rs938554 0.577 rs7683856 chr4:10000947 A/G cg00071950 chr4:10020882 SLC2A9 0.6 7.06 0.4 1.45e-11 Blood metabolite levels; CESC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg09060608 chr5:178986726 RUFY1 0.41 5.96 0.34 8.15e-9 Lung cancer; CESC cis rs9858542 1.000 rs4283605 chr3:49678651 A/G cg03060546 chr3:49711283 APEH -0.59 -6.95 -0.39 2.86e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6752107 1.000 rs6708373 chr2:234172846 A/G cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.36 5.43 0.32 1.25e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs763512 0.504 rs1051838 chr17:35870833 G/A cg16670864 chr17:35848621 DUSP14 0.52 6.36 0.36 8.6e-10 3-hydroxypropylmercapturic acid levels in smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09537216 chr5:72801264 BTF3 -0.56 -6.86 -0.39 4.74e-11 Gut microbiome composition (summer); CESC cis rs8114671 0.804 rs6088666 chr20:33564570 A/G cg24642439 chr20:33292090 TP53INP2 0.46 5.47 0.32 1.06e-7 Height; CESC cis rs2249694 0.960 rs7084391 chr10:135412344 A/C cg20169779 chr10:135381914 SYCE1 -0.4 -5.65 -0.33 4.05e-8 Obesity-related traits; CESC cis rs6963495 0.818 rs116457537 chr7:105152072 A/G cg13798780 chr7:105162888 PUS7 0.76 7.77 0.43 1.79e-13 Bipolar disorder (body mass index interaction); CESC cis rs2070488 0.965 rs7373828 chr3:38524311 A/G cg24069376 chr3:38537580 EXOG 0.49 8.78 0.47 2.03e-16 Electrocardiographic conduction measures; CESC cis rs3126085 0.877 rs57597406 chr1:152246619 C/G cg03465714 chr1:152285911 FLG -0.45 -5.56 -0.32 6.52e-8 Atopic dermatitis; CESC cis rs10392 0.543 rs6028197 chr20:37534193 C/T cg27552599 chr20:37590471 DHX35 0.39 5.64 0.33 4.42e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs7647973 0.593 rs4855885 chr3:49690199 G/A cg13072238 chr3:49761600 GMPPB -0.5 -5.81 -0.34 1.77e-8 Menarche (age at onset); CESC trans rs7815944 1.000 rs58299386 chr8:129451995 C/G cg24350771 chr7:18329602 NA -0.69 -6.05 -0.35 4.9e-9 Atopic dermatitis; CESC trans rs9650657 0.506 rs7823296 chr8:10778546 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -6.35 -0.36 9.47e-10 Neuroticism; CESC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.59 -0.32 5.57e-8 Aortic root size; CESC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg07677032 chr17:61819896 STRADA 0.42 5.38 0.31 1.61e-7 Height; CESC cis rs7772486 0.738 rs9485039 chr6:146319387 C/T cg23711669 chr6:146136114 FBXO30 0.8 11.17 0.57 5.23e-24 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25097514 chr2:219157373 TMBIM1;PNKD -0.57 -6.29 -0.36 1.28e-9 Gut microbiome composition (summer); CESC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg08736216 chr1:53307985 ZYG11A -0.44 -7.35 -0.41 2.52e-12 Monocyte count; CESC cis rs3820928 0.874 rs10195072 chr2:227794452 G/A cg05526886 chr2:227700861 RHBDD1 -0.4 -5.11 -0.3 6.13e-7 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20354231 chr13:53171401 NA -0.58 -6.76 -0.38 8.7e-11 Gut microbiome composition (summer); CESC cis rs6831352 0.918 rs17218560 chr4:100060794 C/T cg13256891 chr4:100009986 ADH5 0.65 7.55 0.42 6.98e-13 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26850559 chr10:3214952 PITRM1 0.56 6.0 0.35 6.45e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20795891 chr22:41985901 PMM1 -0.59 -6.45 -0.37 5.42e-10 Gut microbiome composition (summer); CESC cis rs7107174 0.892 rs2511167 chr11:77964698 C/T cg02023728 chr11:77925099 USP35 0.46 6.47 0.37 4.58e-10 Testicular germ cell tumor; CESC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg05564831 chr3:52568323 NT5DC2 0.46 7.01 0.4 2.01e-11 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26600917 chr1:110162534 AMPD2 -0.44 -6.22 -0.36 1.88e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs72945132 0.769 rs11235754 chr11:70136092 C/T cg00319359 chr11:70116639 PPFIA1 0.78 7.67 0.43 3.32e-13 Coronary artery disease; CESC cis rs7086627 0.515 rs6585994 chr10:82191643 A/G cg00277334 chr10:82204260 NA -0.59 -9.11 -0.49 2.07e-17 Post bronchodilator FEV1; CESC cis rs826838 0.616 rs1601746 chr12:38626195 G/T cg26384229 chr12:38710491 ALG10B -0.44 -6.19 -0.36 2.31e-9 Heart rate; CESC cis rs7833790 0.777 rs1005850 chr8:82692255 G/A cg06027949 chr8:82754900 SNX16 -0.46 -5.27 -0.31 2.82e-7 Diastolic blood pressure; CESC cis rs7917772 0.503 rs11191320 chr10:104293394 T/C cg22532475 chr10:104410764 TRIM8 -0.35 -6.02 -0.35 5.75e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9814567 1.000 rs11706117 chr3:134212526 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.99 -0.35 6.73e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg11752832 chr7:134001865 SLC35B4 0.51 6.61 0.38 2.16e-10 Mean platelet volume; CESC cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg00409905 chr10:38381863 ZNF37A -0.51 -6.8 -0.39 6.98e-11 Extrinsic epigenetic age acceleration; CESC trans rs8057939 0.593 rs11862457 chr16:49442841 C/T cg15532236 chr6:170188124 NA 0.49 6.11 0.35 3.61e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs5753037 0.504 rs140114 chr22:30133881 C/T cg01021169 chr22:30184971 ASCC2 -0.55 -7.87 -0.44 9.34e-14 Type 1 diabetes; CESC cis rs1577917 1.000 rs6940458 chr6:86644992 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -5.52 -0.32 8.09e-8 Response to antipsychotic treatment; CESC cis rs11792861 0.926 rs7856626 chr9:111775502 C/G cg13535736 chr9:111863775 C9orf5 -0.49 -6.48 -0.37 4.34e-10 Menarche (age at onset); CESC cis rs3733585 0.631 rs3822236 chr4:10119961 T/G cg00071950 chr4:10020882 SLC2A9 -0.62 -9.92 -0.52 6.42e-20 Cleft plate (environmental tobacco smoke interaction); CESC cis rs28673728 0.897 rs28391281 chr1:38408974 T/C cg18451016 chr1:38461880 NA 0.4 5.92 0.34 9.92e-9 Red cell distribution width; CESC cis rs7089973 0.872 rs10490908 chr10:116616162 T/C cg23260525 chr10:116636907 FAM160B1 0.38 6.37 0.36 8.29e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10784777 chr12:56552019 MYL6 -0.44 -6.14 -0.35 3.06e-9 Gut microbiota (bacterial taxa); CESC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg23248424 chr5:179741104 GFPT2 -0.57 -7.86 -0.43 9.98e-14 Height; CESC cis rs6087990 0.735 rs2424915 chr20:31378448 C/T cg13636640 chr20:31349939 DNMT3B 0.76 11.98 0.59 1e-26 Ulcerative colitis; CESC cis rs3026101 0.671 rs28409881 chr17:5319100 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.22 0.31 3.64e-7 Body mass index; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10705951 chr16:29985294 TAOK2 -0.5 -5.99 -0.35 6.67e-9 Asthma; CESC cis rs2204008 0.811 rs4882300 chr12:38415224 A/T cg26384229 chr12:38710491 ALG10B -0.63 -9.37 -0.5 3.38e-18 Bladder cancer; CESC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg05025164 chr4:1340916 KIAA1530 0.89 11.85 0.59 2.88e-26 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19759454 chr14:103058807 RCOR1 0.64 6.87 0.39 4.44e-11 Gut microbiome composition (summer); CESC cis rs9300255 0.602 rs2851450 chr12:123703501 C/T cg00376283 chr12:123451042 ABCB9 0.7 8.89 0.48 9.66e-17 Neutrophil percentage of white cells; CESC cis rs9929218 0.861 rs4783667 chr16:68752878 C/A cg02972257 chr16:68554789 NA 0.57 6.54 0.37 3.14e-10 Colorectal cancer; CESC cis rs9486715 0.790 rs2971602 chr6:97022468 C/T cg06623918 chr6:96969491 KIAA0776 -0.95 -15.09 -0.68 1.48e-37 Headache; CESC cis rs9325144 0.560 rs2387923 chr12:38662677 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.1 -0.35 3.79e-9 Morning vs. evening chronotype; CESC cis rs10751667 0.621 rs7394862 chr11:927500 T/C cg06064525 chr11:970664 AP2A2 -0.52 -10.25 -0.53 5.74e-21 Alzheimer's disease (late onset); CESC cis rs8072100 0.871 rs7206971 chr17:45425115 A/G cg08085267 chr17:45401833 C17orf57 0.57 7.79 0.43 1.54e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs1814175 0.607 rs11493324 chr11:50011304 T/C cg15704280 chr7:45808275 SEPT13 -0.83 -11.4 -0.57 8.98e-25 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11695030 chr19:34919128 UBA2 -0.62 -7.3 -0.41 3.28e-12 Gut microbiome composition (summer); CESC cis rs2404602 0.669 rs12916324 chr15:77179603 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.72 -0.33 2.92e-8 Blood metabolite levels; CESC cis rs929354 0.772 rs1182360 chr7:157020550 C/G cg05182265 chr7:156933206 UBE3C -0.5 -7.35 -0.41 2.4e-12 Body mass index; CESC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg02935154 chr7:12443704 VWDE -0.59 -7.88 -0.44 8.25e-14 Coronary artery disease; CESC cis rs3815700 1.000 rs7247420 chr19:33096786 G/A cg02997394 chr19:33096574 ANKRD27 0.7 7.06 0.4 1.5e-11 Eosinophilic esophagitis; CESC cis rs9611565 0.765 rs132920 chr22:41810170 T/C cg03806693 chr22:41940476 POLR3H 1.04 12.37 0.61 4.76e-28 Vitiligo; CESC cis rs425277 1.000 rs262670 chr1:2082458 C/T cg16545954 chr1:2118288 C1orf86 0.33 5.6 0.33 5.35e-8 Height; CESC cis rs10911232 0.507 rs10797814 chr1:182990929 C/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.31 0.63 2.66e-31 Hypertriglyceridemia; CESC cis rs2204008 0.869 rs34438288 chr12:38211582 G/T cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs7223966 1.000 rs8081541 chr17:61812483 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.59 0.38 2.33e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs11190604 1.000 rs11190597 chr10:102293676 A/T cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs7914558 0.933 rs10883814 chr10:104737404 T/C cg15744005 chr10:104629667 AS3MT -0.33 -5.2 -0.3 4.01e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6866344 0.570 rs1079487 chr5:178136005 G/A cg10224037 chr5:178157518 ZNF354A 0.71 8.36 0.46 3.52e-15 Neutrophil percentage of white cells; CESC cis rs9457247 1.000 rs2149091 chr6:167372786 C/T cg23791538 chr6:167370224 RNASET2 0.6 8.49 0.46 1.53e-15 Crohn's disease; CESC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg12463550 chr7:65579703 CRCP 0.5 6.3 0.36 1.21e-9 Aortic root size; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg01300887 chr4:99477634 TSPAN5 0.4 6.02 0.35 5.9e-9 Prevalent atrial fibrillation; CESC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.94 0.56 3.23e-23 Alzheimer's disease; CESC cis rs4450798 0.649 rs9861903 chr3:13786821 G/T cg23332027 chr3:13681764 NA 0.38 5.19 0.3 4.22e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7178909 0.902 rs10459674 chr15:90438295 G/C cg19708238 chr15:90437601 AP3S2 0.43 6.19 0.36 2.25e-9 Common traits (Other); CESC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg24562669 chr7:97807699 LMTK2 0.52 7.42 0.41 1.59e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.21 0.3 3.83e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs736408 0.924 rs2535629 chr3:52833219 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -7.15 -0.4 8.53e-12 Bipolar disorder; CESC cis rs898097 0.801 rs68141193 chr17:80878816 C/T cg19046167 chr17:80928561 B3GNTL1 -0.42 -5.25 -0.31 3.06e-7 Breast cancer; CESC cis rs694739 0.726 rs516124 chr11:64128423 G/T cg23796481 chr11:64053134 BAD;GPR137 0.58 7.16 0.4 7.76e-12 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs2760061 0.599 rs644794 chr1:228148670 T/C cg02753203 chr1:228287806 NA -0.5 -7.16 -0.4 8.16e-12 Diastolic blood pressure; CESC cis rs2404602 0.716 rs4886817 chr15:76877702 C/T cg22467129 chr15:76604101 ETFA -0.35 -5.19 -0.3 4.11e-7 Blood metabolite levels; CESC cis rs1808579 0.935 rs2510344 chr18:21113285 C/T cg14672496 chr18:21087552 C18orf8 -0.42 -6.29 -0.36 1.28e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs9457247 1.000 rs436707 chr6:167388843 T/C cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC cis rs6570726 0.791 rs6918814 chr6:145906028 G/A cg23711669 chr6:146136114 FBXO30 0.85 12.51 0.61 1.56e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.82 0.59 3.55e-26 Platelet count; CESC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg05313129 chr8:58192883 C8orf71 -0.48 -5.62 -0.33 4.88e-8 Developmental language disorder (linguistic errors); CESC cis rs2180341 0.576 rs2057224 chr6:127624414 C/G cg27446573 chr6:127587934 RNF146 0.62 8.53 0.46 1.1e-15 Breast cancer; CESC cis rs6500395 1.000 rs4785247 chr16:48687732 A/C cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg04450456 chr4:17643702 FAM184B 0.37 5.18 0.3 4.48e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs854765 0.929 rs854766 chr17:18012775 A/G cg04398451 chr17:18023971 MYO15A -0.68 -9.32 -0.5 4.89e-18 Total body bone mineral density; CESC cis rs765787 0.530 rs11854690 chr15:45516016 C/T cg24006582 chr15:45444508 DUOX1 -0.58 -7.12 -0.4 1.04e-11 Uric acid levels; CESC cis rs735396 1.000 rs1169310 chr12:121439433 G/A cg02403541 chr12:121454288 C12orf43 0.64 9.22 0.49 9.65e-18 N-glycan levels; CESC cis rs10751667 0.666 rs10902242 chr11:949700 G/A cg20946044 chr11:1010712 AP2A2 -0.38 -5.24 -0.31 3.23e-7 Alzheimer's disease (late onset); CESC cis rs9399135 0.967 rs9373122 chr6:135373534 G/A cg24558204 chr6:135376177 HBS1L 0.5 6.8 0.39 6.92e-11 Red blood cell count; CESC cis rs6500395 0.832 rs8052733 chr16:48691978 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs11122272 0.735 rs2808600 chr1:231534723 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs35146811 0.771 rs6465762 chr7:99620554 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.49 6.06 0.35 4.59e-9 Coronary artery disease; CESC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 8.02 0.44 3.31e-14 Platelet count; CESC cis rs9457247 0.663 rs9457258 chr6:167444254 T/C cg07741184 chr6:167504864 NA 0.34 6.09 0.35 3.9e-9 Crohn's disease; CESC cis rs1797885 0.564 rs2454435 chr3:12586240 T/C cg26432171 chr3:12704882 RAF1 -0.52 -6.88 -0.39 4.38e-11 Immature fraction of reticulocytes; CESC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg16325326 chr1:53192061 ZYG11B 0.61 9.25 0.49 7.64e-18 Monocyte count; CESC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs10489896 0.588 rs10159244 chr1:234588171 C/T cg10395685 chr11:86085715 CCDC81 -0.43 -6.15 -0.35 2.9e-9 Cognitive test performance; CESC cis rs9488822 0.676 rs3798227 chr6:116324898 A/G cg18764771 chr6:116381957 FRK 0.22 5.44 0.32 1.21e-7 Cholesterol, total;LDL cholesterol; CESC trans rs877282 0.853 rs11593836 chr10:756715 G/A cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs2197308 0.740 rs1842595 chr12:37906223 G/A cg26384229 chr12:38710491 ALG10B -0.55 -7.84 -0.43 1.13e-13 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16481032 chr6:26056674 HIST1H1C 0.57 6.52 0.37 3.57e-10 Gut microbiome composition (summer); CESC cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg16482183 chr6:26056742 HIST1H1C 0.38 5.36 0.31 1.84e-7 Height; CESC cis rs8067354 0.645 rs2173120 chr17:57892640 A/T cg02344993 chr17:57696989 CLTC 0.56 6.04 0.35 5.31e-9 Hemoglobin concentration; CESC cis rs9876781 0.559 rs7630053 chr3:48398586 G/A cg11946769 chr3:48343235 NME6 0.4 5.03 0.3 8.94e-7 Longevity; CESC trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21659725 chr3:3221576 CRBN -0.83 -13.55 -0.64 3.87e-32 Intelligence (multi-trait analysis); CESC cis rs3733585 0.699 rs2018643 chr4:9947121 C/T cg11266682 chr4:10021025 SLC2A9 0.57 10.66 0.55 2.67e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg07395648 chr5:131743802 NA 0.41 5.35 0.31 1.86e-7 Blood metabolite levels; CESC cis rs1568889 1.000 rs33937991 chr11:28045260 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.99 0.56 2.12e-23 Bipolar disorder; CESC cis rs1707322 1.000 rs4489497 chr1:46438698 C/T cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs5758265 1 rs5758265 chr22:41617897 G/A cg03806693 chr22:41940476 POLR3H -0.49 -5.44 -0.32 1.19e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6580649 0.943 rs1859444 chr12:48399403 T/C cg05342945 chr12:48394962 COL2A1 -0.55 -6.71 -0.38 1.15e-10 Lung cancer; CESC cis rs4948102 0.599 rs2230197 chr7:56126360 T/C cg09872392 chr7:56161020 PHKG1 -0.45 -7.31 -0.41 3.22e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs2880765 0.566 rs17553249 chr15:86006694 A/G cg19183879 chr15:85880815 NA -0.31 -5.94 -0.34 8.97e-9 Coronary artery disease; CESC cis rs12477438 0.871 rs13396584 chr2:99611768 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.62 7.83 0.43 1.21e-13 Chronic sinus infection; CESC trans rs7089973 0.523 rs34170154 chr10:116740959 C/T cg17463145 chr7:79084011 MAGI2 0.32 6.36 0.36 8.92e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.59 0.47 7.62e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1669338 0.507 rs4685607 chr3:3179400 C/T cg16797762 chr3:3221439 CRBN 0.58 6.33 0.36 1.06e-9 White matter integrity; CESC cis rs12545109 0.842 rs2609975 chr8:57401667 T/C cg09654669 chr8:57350985 NA -0.57 -7.11 -0.4 1.1e-11 Obesity-related traits; CESC cis rs1559088 0.847 rs8100392 chr19:33605933 T/C cg17764715 chr19:33622953 WDR88 0.46 5.94 0.34 8.75e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg03188948 chr7:1209495 NA 0.72 6.93 0.39 3.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg18099408 chr3:52552593 STAB1 -0.33 -5.44 -0.32 1.21e-7 Bipolar disorder; CESC cis rs9300255 0.739 rs4759415 chr12:123743674 C/T cg00376283 chr12:123451042 ABCB9 -0.71 -8.94 -0.48 7.04e-17 Neutrophil percentage of white cells; CESC cis rs8005677 1.000 rs4982709 chr14:23394699 C/T cg01529538 chr14:23388837 RBM23 0.5 6.77 0.38 8.22e-11 Cognitive ability (multi-trait analysis); CESC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg05564831 chr3:52568323 NT5DC2 0.43 6.25 0.36 1.67e-9 Bipolar disorder; CESC cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs921968 0.565 rs6436083 chr2:219639719 C/T cg02176678 chr2:219576539 TTLL4 -0.44 -7.74 -0.43 2.15e-13 Mean corpuscular hemoglobin concentration; CESC cis rs3820068 0.603 rs927207 chr1:15990552 A/G cg17385448 chr1:15911702 AGMAT 0.43 7.11 0.4 1.09e-11 Systolic blood pressure; CESC cis rs8077889 0.672 rs1230400 chr17:41845451 G/A cg26893861 chr17:41843967 DUSP3 -1.02 -19.07 -0.76 1.3e-51 Triglycerides; CESC cis rs11677416 0.813 rs4848299 chr2:113523454 C/A cg27083787 chr2:113543245 IL1A 0.41 5.23 0.31 3.45e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg24829409 chr8:58192753 C8orf71 -0.67 -8.18 -0.45 1.19e-14 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg18337363 chr3:52569053 NT5DC2 0.29 5.08 0.3 7.29e-7 Bipolar disorder; CESC cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs13088281 1.000 rs13088281 chr3:53147576 A/C cg15956490 chr3:53032818 SFMBT1 -0.59 -5.05 -0.3 8.23e-7 Immune reponse to smallpox (secreted IL-2); CESC trans rs6700559 0.810 rs2808248 chr1:200592275 T/C cg13401811 chr12:52345646 ACVR1B -0.48 -6.12 -0.35 3.36e-9 Coronary artery disease; CESC cis rs36051895 0.632 rs11791281 chr9:5172540 G/A cg02405213 chr9:5042618 JAK2 -0.52 -6.5 -0.37 3.95e-10 Pediatric autoimmune diseases; CESC cis rs6032067 0.929 rs34412950 chr20:43805132 C/A cg10761708 chr20:43804764 PI3 0.53 6.37 0.36 8.25e-10 Blood protein levels; CESC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.27e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 1.000 rs10946198 chr6:167404432 C/T cg25258033 chr6:167368657 RNASET2 0.39 5.88 0.34 1.26e-8 Crohn's disease; CESC cis rs17376456 0.825 rs34967135 chr5:93221785 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.38 0.31 1.63e-7 Diabetic retinopathy; CESC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg11764359 chr7:65958608 NA 0.96 15.23 0.68 4.78e-38 Aortic root size; CESC cis rs2280018 0.581 rs7404524 chr16:15129158 A/G cg07549590 chr16:15018862 NA -0.54 -8.65 -0.47 4.92e-16 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs11098499 0.691 rs17009144 chr4:120270795 C/T cg25214090 chr10:38739885 LOC399744 -0.57 -7.96 -0.44 5.12e-14 Corneal astigmatism; CESC cis rs6546537 0.911 rs62133968 chr2:69891910 C/T cg10773587 chr2:69614142 GFPT1 -0.59 -6.87 -0.39 4.49e-11 Serum thyroid-stimulating hormone levels; CESC cis rs854765 0.583 rs62064156 chr17:17822480 C/T cg04398451 chr17:18023971 MYO15A -0.65 -9.11 -0.49 2.08e-17 Total body bone mineral density; CESC cis rs889398 0.677 rs68161338 chr16:69823778 T/G cg09409435 chr16:70099608 PDXDC2 -0.41 -5.16 -0.3 4.92e-7 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00034416 chr1:155278724 FDPS 0.59 6.21 0.36 2.04e-9 Gut microbiome composition (summer); CESC cis rs7179456 0.593 rs514049 chr15:59042363 A/C cg05156742 chr15:59063176 FAM63B -0.74 -10.88 -0.56 4.8e-23 Asperger disorder; CESC cis rs17253792 0.731 rs74823888 chr14:56049800 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.85 5.74 0.33 2.53e-8 Putamen volume; CESC cis rs4566357 0.615 rs1800517 chr2:227915832 G/A cg11843606 chr2:227700838 RHBDD1 -0.51 -6.99 -0.39 2.29e-11 Coronary artery disease; CESC cis rs10463316 0.855 rs13359064 chr5:150765575 G/A cg03212797 chr5:150827313 SLC36A1 -0.46 -5.96 -0.34 8.11e-9 Metabolite levels (Pyroglutamine); CESC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg07870213 chr5:140052090 DND1 -0.45 -6.02 -0.35 5.94e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1448094 0.617 rs7297449 chr12:86468442 A/C cg02569458 chr12:86230093 RASSF9 -0.35 -5.11 -0.3 6.25e-7 Major depressive disorder; CESC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg06600287 chr1:53387719 ECHDC2 -0.29 -5.08 -0.3 7e-7 Monocyte count; CESC cis rs7100689 0.577 rs10749560 chr10:82092801 G/T cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 4.91e-14 Post bronchodilator FEV1; CESC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.14 0.6 2.94e-27 Alzheimer's disease; CESC cis rs2439831 0.850 rs28718261 chr15:44043793 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.7 6.6 0.38 2.25e-10 Lung cancer in ever smokers; CESC cis rs11155671 0.530 rs9383912 chr6:150206615 T/C cg09699651 chr6:150184138 LRP11 0.56 7.84 0.43 1.08e-13 Testicular germ cell tumor; CESC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg11764359 chr7:65958608 NA 0.66 8.54 0.46 1.06e-15 Calcium levels; CESC cis rs2832191 0.671 rs73346699 chr21:30515529 C/T cg08807101 chr21:30365312 RNF160 -0.56 -6.46 -0.37 5.04e-10 Dental caries; CESC cis rs77216612 0.835 rs10845621 chr12:12887977 C/T cg24098013 chr12:12878779 APOLD1 0.58 7.11 0.4 1.06e-11 Lymphocyte counts; CESC cis rs2832191 0.716 rs1888440 chr21:30454484 C/T cg24692254 chr21:30365293 RNF160 0.99 17.57 0.73 2.33e-46 Dental caries; CESC cis rs7084402 0.967 rs1649058 chr10:60317087 G/A cg07615347 chr10:60278583 BICC1 0.61 9.59 0.51 7.04e-19 Refractive error; CESC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs735860 0.712 rs3736732 chr6:53160383 G/T cg10236188 chr6:53219634 NA -0.35 -5.11 -0.3 6.07e-7 Glaucoma; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg22907277 chr7:1156413 C7orf50 0.44 6.43 0.37 5.86e-10 Longevity;Endometriosis; CESC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Parkinson's disease; CESC cis rs11723261 0.509 rs61792240 chr4:128619 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.44 5.24 0.31 3.25e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07272690 chr6:42751244 NA 0.57 6.24 0.36 1.71e-9 Gut microbiome composition (summer); CESC cis rs854765 0.551 rs12600546 chr17:17867614 A/G cg04398451 chr17:18023971 MYO15A -0.7 -9.85 -0.52 1.04e-19 Total body bone mineral density; CESC trans rs5758511 0.773 rs1894714 chr22:42349134 T/G cg15080870 chr19:47770746 CCDC9 -0.5 -6.2 -0.36 2.15e-9 Birth weight; CESC trans rs1908814 0.516 rs13279577 chr8:11793096 C/G cg15556689 chr8:8085844 FLJ10661 0.54 6.58 0.37 2.47e-10 Neuroticism; CESC cis rs1023500 0.573 rs1807494 chr22:42474138 C/G cg04733989 chr22:42467013 NAGA -0.79 -12.05 -0.59 5.98e-27 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16071359 chr2:169312933 LASS6 0.49 6.29 0.36 1.31e-9 Gut microbiota (bacterial taxa); CESC cis rs7605827 0.930 rs13007310 chr2:15710058 A/G cg19274914 chr2:15703543 NA -0.36 -6.54 -0.37 3.13e-10 Educational attainment (years of education); CESC cis rs763014 0.898 rs62030902 chr16:638264 C/G cg00802000 chr16:706648 WDR90 -0.37 -5.33 -0.31 2.07e-7 Height; CESC cis rs853679 0.882 rs4713139 chr6:28092685 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.77 7.12 0.4 9.97e-12 Depression; CESC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg08470875 chr2:26401718 FAM59B 0.71 7.06 0.4 1.43e-11 Gut microbiome composition (summer); CESC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg18904891 chr8:8559673 CLDN23 0.69 8.12 0.45 1.82e-14 Obesity-related traits; CESC cis rs36051895 0.632 rs10974993 chr9:5182159 C/T cg02405213 chr9:5042618 JAK2 -0.5 -6.47 -0.37 4.73e-10 Pediatric autoimmune diseases; CESC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg24250549 chr1:154909240 PMVK 0.73 10.67 0.55 2.38e-22 Prostate cancer; CESC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg22143856 chr6:28129313 ZNF389 0.38 5.33 0.31 2.14e-7 Parkinson's disease; CESC cis rs1538970 0.924 rs4660855 chr1:45899795 A/G cg05343316 chr1:45956843 TESK2 0.89 12.41 0.61 3.59e-28 Platelet count; CESC cis rs7818345 0.935 rs7016592 chr8:19277735 A/G cg11303988 chr8:19266685 CSGALNACT1 0.32 5.84 0.34 1.56e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg12641515 chr19:46296257 DMWD -0.51 -5.72 -0.33 2.89e-8 Coronary artery disease; CESC cis rs116988415 0.539 rs17180350 chr14:65249066 C/T cg25083366 chr14:65239357 SPTB 0.66 5.14 0.3 5.23e-7 Daytime sleep phenotypes; CESC cis rs5769765 0.955 rs1321 chr22:50297435 A/G cg02269571 chr22:50332266 NA -0.47 -6.37 -0.36 8.55e-10 Schizophrenia; CESC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg15352829 chr14:105391018 PLD4 -0.6 -10.68 -0.55 2.23e-22 Rheumatoid arthritis; CESC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.82 -0.34 1.69e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1153858 0.945 rs2467854 chr15:45701597 A/G cg10760299 chr15:45669010 GATM 0.37 5.14 0.3 5.43e-7 Homoarginine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23165545 chr3:49449548 TCTA;RHOA -0.54 -6.09 -0.35 3.88e-9 Gut microbiome composition (summer); CESC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg22029157 chr1:209979665 IRF6 -0.71 -8.69 -0.47 3.94e-16 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10700570 chr7:2281743 NUDT1;FTSJ2 0.54 6.65 0.38 1.63e-10 Gut microbiome composition (summer); CESC cis rs2479106 0.963 rs10818864 chr9:126502619 G/T cg16191174 chr9:126692580 DENND1A -0.48 -6.61 -0.38 2.05e-10 Polycystic ovary syndrome; CESC cis rs11122272 0.735 rs2486740 chr1:231517552 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC trans rs2207136 0.869 rs11964803 chr6:50836774 G/A cg06522515 chr3:184090630 THPO -0.38 -6.58 -0.37 2.55e-10 Myopia; CESC cis rs4595586 0.545 rs4623945 chr12:39364572 A/T cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16275883 chr3:69129409 UBA3 0.45 6.04 0.35 5.2e-9 Intelligence (multi-trait analysis); CESC cis rs3733585 0.806 rs11723382 chr4:9954660 T/C cg00071950 chr4:10020882 SLC2A9 -0.78 -14.51 -0.67 1.66e-35 Cleft plate (environmental tobacco smoke interaction); CESC trans rs7618501 0.966 rs2246832 chr3:49881134 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.43 0.46 2.26e-15 Intelligence (multi-trait analysis); CESC cis rs4604732 0.527 rs77361748 chr1:247626475 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9815354 0.812 rs7639859 chr3:42001987 C/T cg03022575 chr3:42003672 ULK4 0.64 5.83 0.34 1.62e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs6598955 0.694 rs4659416 chr1:26580937 T/G cg00852783 chr1:26633632 UBXN11 0.42 6.15 0.35 2.8e-9 Obesity-related traits; CESC cis rs2637266 1.000 rs2894337 chr10:78344871 C/T cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.54e-13 Pulmonary function; CESC cis rs1784581 0.588 rs7752870 chr6:162422510 T/C cg17173639 chr6:162384350 PARK2 0.56 8.63 0.47 5.61e-16 Itch intensity from mosquito bite; CESC cis rs7429990 0.965 rs11130154 chr3:48069242 C/T cg11946769 chr3:48343235 NME6 -0.44 -5.37 -0.31 1.69e-7 Educational attainment (years of education); CESC cis rs9894429 1.000 rs12948099 chr17:79600799 C/G cg13777783 chr17:79615861 NA -0.35 -5.65 -0.33 4.2e-8 Eye color traits; CESC cis rs6500395 0.775 rs11640119 chr16:48662840 C/T cg04672837 chr16:48644449 N4BP1 0.49 6.25 0.36 1.63e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9487051 0.714 rs6930733 chr6:109631587 T/C cg21918786 chr6:109611834 NA -0.39 -5.71 -0.33 3.06e-8 Reticulocyte fraction of red cells; CESC cis rs8180040 0.966 rs7628631 chr3:47560863 C/T cg27129171 chr3:47204927 SETD2 -0.54 -6.96 -0.39 2.72e-11 Colorectal cancer; CESC cis rs990171 0.506 rs6543107 chr2:102750730 A/T cg22835712 chr2:102737379 NA 0.43 6.06 0.35 4.63e-9 Lymphocyte counts; CESC cis rs11098499 0.908 rs28499576 chr4:120386677 G/A cg09307838 chr4:120376055 NA 0.96 14.11 0.65 4.38e-34 Corneal astigmatism; CESC cis rs7481584 0.624 rs80871 chr11:3049843 A/C cg08508325 chr11:3079039 CARS 0.29 5.17 0.3 4.6e-7 Calcium levels; CESC cis rs2243480 1.000 rs35396113 chr7:65495461 C/T cg18252515 chr7:66147081 NA -1.21 -11.82 -0.59 3.44e-26 Diabetic kidney disease; CESC cis rs2370759 0.945 rs74625866 chr10:32597618 A/T cg18270830 chr10:32634957 EPC1 0.73 7.28 0.41 3.82e-12 Sexual dysfunction (female); CESC cis rs7208859 0.573 rs73267829 chr17:29003939 G/A cg13385521 chr17:29058706 SUZ12P 0.72 5.63 0.33 4.55e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg18876405 chr7:65276391 NA 0.58 7.87 0.44 9.3e-14 Aortic root size; CESC cis rs10851478 0.872 rs11854568 chr15:49843747 T/C cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs8060686 0.545 rs76836953 chr16:68061763 G/C cg26727032 chr16:67993705 SLC12A4 -0.54 -6.16 -0.35 2.74e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01366467 chr20:3185206 DDRGK1 0.56 6.07 0.35 4.41e-9 Gut microbiome composition (summer); CESC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg24675658 chr1:53192096 ZYG11B -0.6 -7.61 -0.42 4.79e-13 Monocyte count; CESC cis rs12765878 0.967 rs11598018 chr10:105661315 C/A cg24587175 chr10:105670608 OBFC1 0.33 5.5 0.32 8.89e-8 Coronary artery disease; CESC cis rs6974235 0.777 rs42070 chr7:95715768 A/T cg21022364 chr7:95948586 SLC25A13 0.39 5.59 0.32 5.58e-8 Total body bone mineral density; CESC cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg12386194 chr3:101231763 SENP7 0.61 6.61 0.38 2.08e-10 Colonoscopy-negative controls vs population controls; CESC cis rs2952156 0.652 rs11869286 chr17:37813856 C/G cg07936489 chr17:37558343 FBXL20 -0.61 -8.23 -0.45 8.72e-15 Asthma; CESC cis rs11148252 0.553 rs2147692 chr13:53287023 C/G cg00495681 chr13:53174319 NA 0.63 8.65 0.47 5.19e-16 Lewy body disease; CESC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.38 0.37 7.72e-10 Prudent dietary pattern; CESC cis rs3733585 0.604 rs73215003 chr4:10126317 C/G cg11266682 chr4:10021025 SLC2A9 -0.57 -10.49 -0.54 9.26e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg05863683 chr7:1912471 MAD1L1 0.38 5.46 0.32 1.1e-7 Schizophrenia; CESC cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg23711669 chr6:146136114 FBXO30 1.02 15.96 0.7 1.2e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.12 -22.22 -0.81 1.76e-62 Prudent dietary pattern; CESC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg18099408 chr3:52552593 STAB1 -0.38 -6.47 -0.37 4.69e-10 Electroencephalogram traits; CESC cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.721 rs10157795 chr1:46228192 G/A cg05343316 chr1:45956843 TESK2 0.47 6.02 0.35 5.8e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7223966 1.000 rs16947005 chr17:61702989 C/T cg11494091 chr17:61959527 GH2 -0.38 -5.05 -0.3 8.2e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs478304 0.580 rs11606947 chr11:65508237 A/C cg27068330 chr11:65405492 SIPA1 -0.45 -5.46 -0.32 1.08e-7 Acne (severe); CESC cis rs116095464 0.558 rs59113266 chr5:279965 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.41 0.32 1.38e-7 Breast cancer; CESC cis rs6951245 0.882 rs11764817 chr7:1064610 T/C cg24642844 chr7:1081250 C7orf50 -0.63 -8.09 -0.45 2.11e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8072100 0.817 rs9905581 chr17:45547185 C/T cg08085267 chr17:45401833 C17orf57 -0.58 -7.68 -0.43 3.1400000000000003e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg19046167 chr17:80928561 B3GNTL1 -0.38 -5.2 -0.3 3.92e-7 Breast cancer; CESC trans rs17685 0.712 rs11764119 chr7:75812358 T/G cg19862616 chr7:65841803 NCRNA00174 0.82 11.62 0.58 1.71e-25 Coffee consumption;Coffee consumption (cups per day); CESC cis rs9926296 0.632 rs4785716 chr16:89801127 T/C cg04287289 chr16:89883240 FANCA 0.66 8.97 0.48 5.71e-17 Vitiligo; CESC cis rs11166629 1.000 rs6981735 chr8:135635730 T/C cg21672855 chr8:135614777 ZFAT 0.4 5.03 0.3 9.02e-7 Smoking quantity; CESC cis rs2806561 0.765 rs1738468 chr1:23510850 T/G cg12483005 chr1:23474871 LUZP1 0.38 6.01 0.35 6.26e-9 Height; CESC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.47e-7 Life satisfaction; CESC cis rs11626933 1.000 rs2236402 chr14:90734378 C/G cg14092571 chr14:90743983 NA -0.94 -14.47 -0.66 2.19e-35 Gut microbiota (bacterial taxa); CESC cis rs4566357 0.557 rs2272201 chr2:227912551 T/A cg05526886 chr2:227700861 RHBDD1 -0.47 -6.28 -0.36 1.35e-9 Coronary artery disease; CESC cis rs72781680 0.898 rs111460347 chr2:24018833 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.93e-7 Lung cancer; CESC cis rs7264396 0.690 rs2425172 chr20:34443893 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.6 6.93 0.39 3.25e-11 Total cholesterol levels; CESC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg00149659 chr3:10157352 C3orf10 0.77 9.67 0.51 3.91e-19 Alzheimer's disease; CESC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs4919087 0.926 rs10882884 chr10:99025611 T/A cg25902810 chr10:99078978 FRAT1 0.68 9.92 0.52 6.16e-20 Monocyte count; CESC cis rs11190604 1.000 rs2298075 chr10:102247408 C/A cg07080220 chr10:102295463 HIF1AN 0.55 5.43 0.32 1.3e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs11098499 0.663 rs9996501 chr4:120238918 C/A cg09307838 chr4:120376055 NA 0.78 10.39 0.54 1.94e-21 Corneal astigmatism; CESC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg03806693 chr22:41940476 POLR3H -1.06 -12.46 -0.61 2.35e-28 Vitiligo; CESC cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg00033643 chr7:134001901 SLC35B4 0.44 5.59 0.32 5.6e-8 Mean platelet volume; CESC cis rs6460942 0.915 rs10488158 chr7:12508894 C/T cg10578991 chr7:12443926 VWDE -0.48 -5.14 -0.3 5.44e-7 Coronary artery disease; CESC cis rs7208859 0.623 rs9911173 chr17:29154750 C/T cg13385521 chr17:29058706 SUZ12P 0.75 5.95 0.34 8.3e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs72829446 0.530 rs59665520 chr17:7383136 C/A cg02795151 chr17:7402630 POLR2A 0.55 5.86 0.34 1.41e-8 Androgen levels; CESC trans rs7537660 0.562 rs4417105 chr1:248016487 G/T cg17509220 chr19:13617012 CACNA1A 0.36 6.02 0.35 5.84e-9 Platelet distribution width; CESC cis rs4924935 0.683 rs34413375 chr17:18802028 C/A cg26378065 chr17:18585709 ZNF286B -0.49 -5.18 -0.3 4.47e-7 Pancreatic cancer; CESC cis rs3733585 0.699 rs60045583 chr4:9971950 G/A cg00071950 chr4:10020882 SLC2A9 -0.7 -11.32 -0.57 1.7e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7927592 0.763 rs3740628 chr11:68381415 A/G cg01657329 chr11:68192670 LRP5 -0.44 -5.66 -0.33 3.9e-8 Total body bone mineral density; CESC cis rs832540 0.866 rs252894 chr5:56224339 A/C cg14703610 chr5:56206110 C5orf35 -0.48 -5.85 -0.34 1.44e-8 Coronary artery disease; CESC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg06456125 chr7:65229604 NA -0.39 -5.04 -0.3 8.55e-7 Aortic root size; CESC cis rs189218934 1 rs189218934 chr15:78903987 T/C cg24631222 chr15:78858424 CHRNA5 -0.8 -10.05 -0.53 2.41e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs61935443 0.720 rs10859784 chr12:95288926 G/A cg21533806 chr12:95267307 NA 0.55 6.6 0.38 2.17e-10 Schizophrenia; CESC cis rs2228479 0.850 rs12597296 chr16:89822331 C/T cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs4819052 0.620 rs421619 chr21:46546115 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 5.51 0.32 8.43e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11574514 1.000 rs11861657 chr16:67824395 A/G cg26727032 chr16:67993705 SLC12A4 -0.57 -5.07 -0.3 7.66e-7 Crohn's disease; CESC cis rs7647973 0.769 rs6772452 chr3:49040462 A/G cg06212747 chr3:49208901 KLHDC8B 0.57 7.19 0.4 6.51e-12 Menarche (age at onset); CESC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg18876405 chr7:65276391 NA -0.51 -7.07 -0.4 1.39e-11 Aortic root size; CESC cis rs6938 0.534 rs59945415 chr15:75228427 C/A cg17294928 chr15:75287854 SCAMP5 0.48 6.26 0.36 1.54e-9 Breast cancer; CESC cis rs1707322 0.721 rs10890346 chr1:46223892 C/T cg06784218 chr1:46089804 CCDC17 -0.4 -7.14 -0.4 8.84e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4925386 0.681 rs2427295 chr20:60927431 G/A cg22307297 chr20:60903441 LAMA5 0.37 5.28 0.31 2.65e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg17366294 chr4:99064904 C4orf37 0.6 8.6 0.47 7.1e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7116495 1.000 rs73543609 chr11:71816619 G/T cg26138937 chr11:71823887 C11orf51 0.85 6.85 0.39 5.03e-11 Severe influenza A (H1N1) infection; CESC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg19592336 chr6:28129416 ZNF389 0.51 7.03 0.4 1.73e-11 Depression; CESC cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg24690094 chr11:67383802 NA 0.39 6.62 0.38 1.99e-10 Mean corpuscular volume; CESC cis rs4664308 0.967 rs17241973 chr2:160918601 A/G cg03641300 chr2:160917029 PLA2R1 -0.67 -10.0 -0.52 3.57e-20 Idiopathic membranous nephropathy; CESC cis rs34779708 0.931 rs11597483 chr10:35285117 A/G cg04310649 chr10:35416472 CREM -0.5 -6.06 -0.35 4.78e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs1215050 0.740 rs2695464 chr4:98980929 T/C cg05340658 chr4:99064831 C4orf37 -0.57 -7.73 -0.43 2.26e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg18446336 chr7:2847575 GNA12 -0.37 -5.53 -0.32 7.69e-8 Height; CESC cis rs933688 1.000 rs6867091 chr5:90734333 C/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.05 13.7 0.64 1.18e-32 Smoking behavior; CESC cis rs2979489 0.786 rs2979514 chr8:30399461 A/C cg26383811 chr8:30366931 RBPMS -0.79 -10.0 -0.52 3.48e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs2204008 0.652 rs11513964 chr12:37998214 C/G cg26384229 chr12:38710491 ALG10B 0.74 10.87 0.56 5.15e-23 Bladder cancer; CESC cis rs9649465 1.000 rs2299983 chr7:123356642 C/G cg04330084 chr7:123175371 IQUB -0.39 -5.23 -0.31 3.47e-7 Migraine; CESC cis rs2730245 0.550 rs2709860 chr7:158651156 A/T cg14689365 chr7:158441557 NCAPG2 0.42 5.3 0.31 2.47e-7 Height; CESC cis rs7429990 0.965 rs796566 chr3:47938354 G/C cg11946769 chr3:48343235 NME6 0.42 5.05 0.3 8.38e-7 Educational attainment (years of education); CESC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg07507251 chr3:52567010 NT5DC2 0.33 5.68 0.33 3.6e-8 Electroencephalogram traits; CESC cis rs7267979 1.000 rs6115146 chr20:25304507 G/A cg08601574 chr20:25228251 PYGB -0.39 -5.7 -0.33 3.23e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs60843830 0.964 rs7584915 chr2:264227 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.49 0.54 9.31e-22 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg11764359 chr7:65958608 NA 0.71 9.39 0.5 2.85e-18 Aortic root size; CESC cis rs72634258 0.945 rs35675666 chr1:8021973 G/T cg00042356 chr1:8021962 PARK7 0.82 7.85 0.43 1e-13 Inflammatory bowel disease; CESC cis rs11690935 0.843 rs9784123 chr2:172785005 T/A cg13550731 chr2:172543902 DYNC1I2 -0.84 -12.15 -0.6 2.63e-27 Schizophrenia; CESC cis rs7267979 0.932 rs2260997 chr20:25256266 A/C cg08601574 chr20:25228251 PYGB -0.4 -5.88 -0.34 1.22e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg14403583 chr14:105418241 AHNAK2 -0.57 -7.86 -0.43 9.9e-14 Rheumatoid arthritis; CESC cis rs965513 1.000 rs7030256 chr9:100535203 C/G cg13688889 chr9:100608707 NA -0.6 -8.57 -0.47 8.76e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg08470875 chr2:26401718 FAM59B -0.49 -5.54 -0.32 7.17e-8 Gut microbiome composition (summer); CESC cis rs854765 0.547 rs7224047 chr17:17932931 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.43 0.37 5.86e-10 Total body bone mineral density; CESC cis rs798766 1.000 rs3752749 chr4:1737262 T/C cg10756475 chr4:1757242 NA 0.46 6.02 0.35 5.9e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs9894429 1.000 rs7406003 chr17:79597597 C/T cg21984481 chr17:79567631 NPLOC4 -0.49 -7.86 -0.43 9.77e-14 Eye color traits; CESC cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg02297831 chr4:17616191 MED28 0.43 5.21 0.3 3.81e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs56104184 0.775 rs55756106 chr19:49403055 A/G cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26675182 chr7:2405750 EIF3B 0.5 6.16 0.35 2.65e-9 Ulcerative colitis; CESC cis rs2637266 0.667 rs2395406 chr10:78380519 G/A cg18941641 chr10:78392320 NA 0.4 7.34 0.41 2.59e-12 Pulmonary function; CESC cis rs1348850 0.872 rs4893824 chr2:178298104 G/A cg23306229 chr2:178417860 TTC30B 0.58 6.78 0.38 7.59e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.81 10.27 0.53 4.75e-21 Alzheimer's disease; CESC cis rs12136530 0.774 rs12562821 chr1:19786650 C/T cg01832549 chr1:19774989 CAPZB -0.43 -5.98 -0.35 7e-9 Lead levels in blood; CESC cis rs4803468 1.000 rs284649 chr19:41926838 C/T cg09537434 chr19:41945824 ATP5SL -1.1 -20.32 -0.78 5.54e-56 Height; CESC cis rs875971 0.662 rs448725 chr7:65514628 A/G cg26939375 chr7:64535504 NA 0.48 6.19 0.36 2.32e-9 Aortic root size; CESC cis rs6502050 0.799 rs4482345 chr17:80152919 G/A cg23985595 chr17:80112537 CCDC57 -0.4 -6.33 -0.36 1.05e-9 Life satisfaction; CESC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.52 -6.87 -0.39 4.66e-11 Menarche (age at onset); CESC cis rs7772486 0.875 rs7767660 chr6:146436550 T/C cg23711669 chr6:146136114 FBXO30 0.78 11.5 0.58 4.13e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg16545954 chr1:2118288 C1orf86 0.35 6.55 0.37 2.95e-10 Height; CESC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg05368731 chr17:41323189 NBR1 0.77 10.96 0.56 2.61e-23 Menopause (age at onset); CESC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.94 0.52 5.31e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9916302 0.706 rs8073907 chr17:37424149 C/T cg07936489 chr17:37558343 FBXL20 -0.97 -11.45 -0.58 6.08e-25 Glomerular filtration rate (creatinine); CESC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg22143856 chr6:28129313 ZNF389 0.42 5.27 0.31 2.83e-7 Parkinson's disease; CESC cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg16339924 chr4:17578868 LAP3 0.64 7.91 0.44 6.79e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6546550 0.933 rs6546554 chr2:70135706 G/A cg02498382 chr2:70120550 SNRNP27 -0.4 -7.03 -0.4 1.71e-11 Prevalent atrial fibrillation; CESC cis rs7317038 1.000 rs7317038 chr13:114012898 C/T cg24344662 chr13:114018021 GRTP1 -0.51 -6.53 -0.37 3.27e-10 Mean platelet volume; CESC cis rs9486719 1.000 rs11757063 chr6:96884886 C/T cg06623918 chr6:96969491 KIAA0776 -0.75 -7.65 -0.43 3.78e-13 Migraine;Coronary artery disease; CESC cis rs548181 0.609 rs511822 chr11:125534115 C/T cg03464685 chr11:125439445 EI24 1.06 8.92 0.48 8e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg25208724 chr1:156163844 SLC25A44 1.0 19.1 0.76 9.89e-52 Testicular germ cell tumor; CESC cis rs568617 0.953 rs583887 chr11:65644027 T/C cg19792802 chr11:65647270 CTSW -0.35 -5.31 -0.31 2.33e-7 Crohn's disease; CESC cis rs8103278 1.000 rs8108590 chr19:46301620 A/G cg11657440 chr19:46296263 DMWD -0.58 -7.23 -0.41 5.09e-12 Coronary artery disease; CESC cis rs11825685 0.887 rs78806216 chr11:134568320 C/T cg06603561 chr11:134479413 NA -0.63 -5.41 -0.32 1.39e-7 IgG glycosylation; CESC cis rs17401966 0.964 rs17400510 chr1:10290421 T/C cg15208524 chr1:10270712 KIF1B 0.47 6.14 0.35 3.07e-9 Hepatocellular carcinoma; CESC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg03806693 chr22:41940476 POLR3H -1.24 -16.52 -0.71 1.2e-42 Vitiligo; CESC cis rs3806843 0.966 rs2563265 chr5:140137005 C/T cg16179182 chr5:140090404 VTRNA1-1 0.41 5.41 0.32 1.41e-7 Depressive symptoms (multi-trait analysis); CESC cis rs10447248 0.674 rs6859569 chr5:107893771 A/G cg25075504 chr5:107899390 NA -0.39 -6.0 -0.35 6.42e-9 Adiponectin levels; CESC cis rs2439831 1.000 rs2444250 chr15:43785051 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.83 11.92 0.59 1.68e-26 Lung cancer in ever smokers; CESC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg25427524 chr10:38739819 LOC399744 0.66 9.65 0.51 4.45e-19 Extrinsic epigenetic age acceleration; CESC cis rs11828289 0.660 rs74388652 chr11:23188048 A/G cg20040320 chr11:23191996 NA -0.68 -5.87 -0.34 1.31e-8 Cancer; CESC cis rs7589728 1.000 rs2363731 chr2:88521793 C/T cg04511125 chr2:88470314 THNSL2 0.58 5.62 0.33 4.88e-8 Plasma clusterin levels; CESC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg24675658 chr1:53192096 ZYG11B -0.54 -6.59 -0.38 2.32e-10 Monocyte count; CESC cis rs5753037 0.653 rs140107 chr22:30130516 C/A cg01021169 chr22:30184971 ASCC2 -0.43 -5.88 -0.34 1.26e-8 Type 1 diabetes; CESC cis rs6968419 0.547 rs72603593 chr7:115894376 T/C cg02561103 chr7:115862891 TES -0.4 -5.21 -0.3 3.76e-7 Intraocular pressure; CESC cis rs6545883 0.894 rs4672436 chr2:61603357 A/C cg15711740 chr2:61764176 XPO1 0.4 5.1 0.3 6.53e-7 Tuberculosis; CESC cis rs796364 0.806 rs74706215 chr2:200941367 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.82 -7.29 -0.41 3.5e-12 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21843114 chr4:26334859 RBPJ 0.43 6.03 0.35 5.61e-9 Fibrinogen levels; CESC trans rs7307889 0.793 rs12308152 chr12:6008861 A/C cg18407955 chr7:158110685 PTPRN2 -0.72 -6.68 -0.38 1.41e-10 Obesity-related traits; CESC cis rs1707322 1.000 rs4660906 chr1:46470860 C/T cg05343316 chr1:45956843 TESK2 0.44 5.28 0.31 2.65e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12477438 0.520 rs12467504 chr2:99543208 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -5.37 -0.31 1.7e-7 Chronic sinus infection; CESC cis rs7829975 0.514 rs2920991 chr8:8259117 T/A cg06636001 chr8:8085503 FLJ10661 0.53 7.06 0.4 1.45e-11 Mood instability; CESC cis rs9488822 0.676 rs1556857 chr6:116325559 T/C cg26893134 chr6:116381904 FRK 0.25 6.04 0.35 5.06e-9 Cholesterol, total;LDL cholesterol; CESC cis rs10416265 0.527 rs7508599 chr19:33546512 A/T cg03563238 chr19:33554763 RHPN2 -0.31 -5.56 -0.32 6.64e-8 Bone properties (heel); CESC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg12288994 chr5:1860383 NA 0.43 7.05 0.4 1.52e-11 Cardiovascular disease risk factors; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08655493 chr21:33765248 URB1;C21orf119 0.46 6.12 0.35 3.31e-9 Systemic lupus erythematosus; CESC cis rs2835872 0.758 rs1709835 chr21:39037636 A/G cg06728970 chr21:39037746 KCNJ6 0.3 5.53 0.32 7.57e-8 Electroencephalographic traits in alcoholism; CESC cis rs7116495 0.881 rs1892921 chr11:71702138 G/A cg10381502 chr11:71823885 C11orf51 -0.68 -5.91 -0.34 1.05e-8 Severe influenza A (H1N1) infection; CESC cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg02297831 chr4:17616191 MED28 0.61 7.82 0.43 1.23e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06391473 chr2:238875301 UBE2F 0.59 7.02 0.4 1.84e-11 Gut microbiome composition (summer); CESC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg17372223 chr3:52568218 NT5DC2 0.43 6.19 0.36 2.23e-9 Bipolar disorder; CESC cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg12826209 chr6:26865740 GUSBL1 0.75 8.45 0.46 1.9e-15 Intelligence (multi-trait analysis); CESC cis rs9326248 0.530 rs1351452 chr11:116943354 G/T cg01368799 chr11:117014884 PAFAH1B2 -0.56 -5.14 -0.3 5.39e-7 Blood protein levels; CESC cis rs7223966 1.000 rs9899491 chr17:61934384 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 6.26 0.36 1.56e-9 Hip circumference adjusted for BMI;Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04067598 chr5:70751409 BDP1 0.46 6.56 0.37 2.84e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6982240 0.514 rs892362 chr8:142269214 A/G cg27411547 chr8:142287226 NA 0.51 7.31 0.41 3.11e-12 Tonsillectomy; CESC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg11494091 chr17:61959527 GH2 0.72 12.07 0.6 4.86e-27 Prudent dietary pattern; CESC cis rs914615 0.552 rs11264339 chr1:155140648 A/G cg02153340 chr1:155202674 NA 0.35 5.2 0.3 3.97e-7 Urinary albumin-to-creatinine ratio; CESC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg24675658 chr1:53192096 ZYG11B 0.57 7.82 0.43 1.23e-13 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15216925 chr5:179921655 CNOT6 0.61 6.56 0.37 2.89e-10 Gut microbiome composition (summer); CESC cis rs17539620 0.624 rs871069 chr6:154837578 A/C cg20019720 chr6:154832845 CNKSR3 0.47 6.13 0.35 3.21e-9 Lipoprotein (a) levels; CESC trans rs1814175 0.935 rs1827017 chr11:49632592 C/G cg03929089 chr4:120376271 NA -0.87 -13.32 -0.63 2.44e-31 Height; CESC cis rs6540556 0.859 rs12079960 chr1:209937168 A/C cg23920097 chr1:209922102 NA -0.35 -5.15 -0.3 5.07e-7 Red blood cell count; CESC cis rs1124376 0.748 rs6771367 chr3:20160266 A/T cg05072819 chr3:20081367 KAT2B 0.47 5.56 0.32 6.47e-8 Bipolar disorder and schizophrenia; CESC cis rs10089 0.953 rs114881127 chr5:127369661 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 9.55 0.51 8.83e-19 Ileal carcinoids; CESC cis rs3820068 0.581 rs59684759 chr1:15919893 A/G cg13390004 chr1:15929781 NA 0.32 5.06 0.3 7.96e-7 Systolic blood pressure; CESC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg17372223 chr3:52568218 NT5DC2 0.45 6.61 0.38 2.14e-10 Bipolar disorder; CESC cis rs668210 0.947 rs559161 chr11:65761637 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.75 9.25 0.49 7.89e-18 Cerebrospinal fluid biomarker levels; CESC cis rs2274273 0.805 rs60972460 chr14:55571773 A/T cg04306507 chr14:55594613 LGALS3 0.29 5.79 0.34 1.95e-8 Protein biomarker; CESC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.46e-17 Gut microbiome composition (summer); CESC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg23803603 chr1:2058230 PRKCZ -0.37 -6.73 -0.38 1.03e-10 Height; CESC trans rs10506458 0.915 rs17763441 chr12:63418335 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.34 -18.36 -0.75 3.77e-49 Hemostatic factors and hematological phenotypes; CESC cis rs4481887 0.639 rs10749644 chr1:248414587 A/C cg00666640 chr1:248458726 OR2T12 0.32 5.37 0.31 1.71e-7 Common traits (Other); CESC cis rs1707322 1.000 rs11211190 chr1:46266255 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.7 0.33 3.24e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg19539972 chr4:7069911 GRPEL1 0.78 9.73 0.51 2.48e-19 Monocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13445258 chr3:128369860 RPN1 0.51 6.63 0.38 1.82e-10 Gut microbiota (bacterial taxa); CESC cis rs870825 0.860 rs72689297 chr4:185600957 A/T cg04058563 chr4:185651563 MLF1IP 0.57 5.29 0.31 2.54e-7 Blood protein levels; CESC cis rs9443189 0.855 rs2842554 chr6:76455557 C/A cg01950844 chr6:76311363 SENP6 -0.6 -6.63 -0.38 1.82e-10 Prostate cancer; CESC cis rs61935443 0.614 rs11107792 chr12:95317126 G/C cg21533806 chr12:95267307 NA 0.5 5.36 0.31 1.78e-7 Schizophrenia; CESC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.12 0.3 5.88e-7 Menopause (age at onset); CESC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9443189 0.526 rs6902898 chr6:76201856 G/A cg01950844 chr6:76311363 SENP6 0.87 8.92 0.48 7.77e-17 Prostate cancer; CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg18099408 chr3:52552593 STAB1 -0.4 -7.29 -0.41 3.59e-12 Electroencephalogram traits; CESC cis rs9815354 0.556 rs113213296 chr3:41873097 G/A cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.83e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10835230 chr19:2457145 LMNB2 0.57 6.18 0.35 2.4e-9 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg24562669 chr7:97807699 LMTK2 0.47 6.73 0.38 1.07e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs11229555 0.645 rs34530191 chr11:58200854 A/G cg15696309 chr11:58395628 NA -0.42 -5.05 -0.3 8.13e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs4237845 0.780 rs3751331 chr12:58290278 G/A cg02175503 chr12:58329896 NA 0.61 7.33 0.41 2.85e-12 Intelligence (multi-trait analysis); CESC cis rs77956314 0.515 rs4238051 chr12:117366299 A/G cg02017074 chr12:117425053 FBXW8 0.77 8.03 0.44 3.3e-14 Subcortical brain region volumes;Hippocampal volume; CESC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg25427524 chr10:38739819 LOC399744 -0.66 -9.68 -0.51 3.58e-19 Extrinsic epigenetic age acceleration; CESC cis rs72781680 0.950 rs72796343 chr2:24147631 G/A cg20701182 chr2:24300061 SF3B14 0.79 6.77 0.38 8.12e-11 Lymphocyte counts; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08243778 chr1:212458726 PPP2R5A -0.46 -6.37 -0.36 8.31e-10 Gut microbiota (bacterial taxa); CESC cis rs7100689 0.646 rs7894762 chr10:82086779 C/G cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 4.91e-14 Post bronchodilator FEV1; CESC trans rs208520 0.874 rs208481 chr6:66922636 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.84 -9.84 -0.52 1.14e-19 Exhaled nitric oxide output; CESC cis rs6582630 0.519 rs12368889 chr12:38315160 G/A cg13010199 chr12:38710504 ALG10B 0.51 6.33 0.36 1.07e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7208859 0.573 rs8078656 chr17:29080971 A/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6460942 1.000 rs17191008 chr7:12417690 T/G cg06484146 chr7:12443880 VWDE -0.8 -9.06 -0.49 3.01e-17 Coronary artery disease; CESC cis rs7560272 0.538 rs6732812 chr2:73922475 T/C cg20560298 chr2:73613845 ALMS1 0.46 6.3 0.36 1.23e-9 Schizophrenia; CESC cis rs6831352 0.879 rs2602888 chr4:100041706 C/T cg12011299 chr4:100065546 ADH4 0.6 6.57 0.37 2.59e-10 Alcohol dependence; CESC cis rs6580649 0.941 rs11612970 chr12:48451009 T/C cg24011408 chr12:48396354 COL2A1 -0.42 -5.28 -0.31 2.67e-7 Lung cancer; CESC cis rs28489187 0.706 rs2300637 chr1:85822772 T/C cg16011679 chr1:85725395 C1orf52 0.55 6.34 0.36 1e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC cis rs6493487 0.512 rs16953045 chr15:51251122 A/C cg02338191 chr15:51200825 AP4E1 0.59 5.62 0.33 4.83e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg08984405 chr17:685103 RNMTL1;GLOD4 -0.41 -6.11 -0.35 3.46e-9 Vertical cup-disc ratio; CESC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.84 0.43 1.14e-13 Prudent dietary pattern; CESC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg11965913 chr1:205819406 PM20D1 0.39 5.17 0.3 4.73e-7 Parkinson's disease; CESC cis rs11650494 0.706 rs76778410 chr17:47459877 A/T cg08112188 chr17:47440006 ZNF652 1.27 8.48 0.46 1.62e-15 Prostate cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24744501 chr2:207024175 NDUFS1;EEF1B2 -0.54 -6.76 -0.38 8.96e-11 Ulcerative colitis; CESC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg00310523 chr12:86230176 RASSF9 0.35 5.57 0.32 6.17e-8 Major depressive disorder; CESC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg00106254 chr7:1943704 MAD1L1 -0.49 -6.05 -0.35 4.88e-9 Bipolar disorder and schizophrenia; CESC cis rs9811920 0.638 rs793440 chr3:99643176 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -5.38 -0.31 1.67e-7 Axial length; CESC cis rs6088580 0.634 rs4911420 chr20:32998654 A/G cg24642439 chr20:33292090 TP53INP2 -0.52 -7.06 -0.4 1.46e-11 Glomerular filtration rate (creatinine); CESC cis rs941207 0.507 rs73337030 chr12:57046194 T/A cg05584118 chr12:57595605 LRP1 0.36 5.1 0.3 6.38e-7 Platelet count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08483723 chr3:45267960 TMEM158 0.46 6.78 0.38 7.88e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6032067 1.000 rs6017509 chr20:43830362 A/G cg10761708 chr20:43804764 PI3 0.52 6.32 0.36 1.07e-9 Blood protein levels; CESC cis rs7312933 0.703 rs10459290 chr12:42613290 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.35 0.36 9.35e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs3960554 0.599 rs56090527 chr7:75762125 A/C cg19862616 chr7:65841803 NCRNA00174 0.58 6.08 0.35 4.12e-9 Eotaxin levels; CESC cis rs9616064 0.531 rs9616086 chr22:47050744 G/A cg05621596 chr22:47072043 GRAMD4 -0.68 -9.8 -0.52 1.45e-19 Urate levels in obese individuals; CESC cis rs3026101 0.723 rs1544400 chr17:5305924 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.45 6.06 0.35 4.6e-9 Body mass index; CESC cis rs2050392 0.590 rs17547917 chr10:30718303 G/A cg25182066 chr10:30743637 MAP3K8 -0.46 -5.98 -0.34 7.32e-9 Inflammatory bowel disease; CESC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg04025307 chr7:1156635 C7orf50 0.37 5.82 0.34 1.71e-8 Longevity;Endometriosis; CESC cis rs6463523 0.864 rs73047957 chr7:759373 A/T cg14391382 chr7:866102 UNC84A 0.48 5.97 0.34 7.53e-9 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24232869 chr12:48478849 SENP1 -0.64 -7.39 -0.41 1.88e-12 Gut microbiome composition (summer); CESC cis rs714031 0.934 rs2235341 chr22:40068679 T/G cg21377881 chr22:40064566 CACNA1I -0.32 -5.15 -0.3 5.15e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00717482 chr1:112531938 KCND3 0.57 6.24 0.36 1.77e-9 Gut microbiome composition (summer); CESC cis rs60871478 1.000 rs62432242 chr7:797715 G/A cg05535760 chr7:792225 HEATR2 0.84 10.4 0.54 1.75e-21 Cerebrospinal P-tau181p levels; CESC cis rs12822507 0.868 rs12830917 chr12:12792516 C/A cg11838227 chr12:12764436 CREBL2 -0.41 -5.32 -0.31 2.21e-7 Systemic lupus erythematosus; CESC cis rs6460942 0.597 rs17277369 chr7:12536192 A/G cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg10295955 chr4:187884368 NA -1.02 -18.0 -0.74 7.4e-48 Lobe attachment (rater-scored or self-reported); CESC cis rs2629540 0.543 rs2559515 chr10:126513925 A/G cg08799069 chr10:126477246 METTL10 0.5 5.74 0.33 2.65e-8 Cocaine dependence; CESC cis rs4268898 0.662 rs55661701 chr2:24400769 A/C cg08917208 chr2:24149416 ATAD2B 0.62 5.7 0.33 3.21e-8 Asthma; CESC cis rs9420 0.961 rs11607056 chr11:57496820 C/T cg19752551 chr11:57585705 CTNND1 -0.36 -5.07 -0.3 7.55e-7 Schizophrenia; CESC cis rs2708240 0.577 rs2888536 chr7:147566862 G/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.4 -6.41 -0.37 6.59e-10 QT interval (drug interaction); CESC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.84 8.31 0.45 4.88e-15 Platelet count; CESC cis rs9487051 0.768 rs435611 chr6:109527755 C/T cg01475377 chr6:109611718 NA -0.44 -6.65 -0.38 1.71e-10 Reticulocyte fraction of red cells; CESC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.78 0.65 6.16e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8016982 0.633 rs8019108 chr14:81716781 A/T cg01989461 chr14:81687754 GTF2A1 0.71 11.02 0.56 1.75e-23 Schizophrenia; CESC cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg06544989 chr22:39130855 UNC84B -0.5 -8.31 -0.45 4.92e-15 Menopause (age at onset); CESC cis rs10129255 0.957 rs10136781 chr14:107188690 G/T cg23076370 chr14:107095027 NA -0.46 -5.95 -0.34 8.57e-9 Kawasaki disease; CESC cis rs2124969 0.506 rs10497209 chr2:160985586 A/C cg03641300 chr2:160917029 PLA2R1 -0.56 -5.79 -0.34 2.01e-8 Waist circumference adjusted for body mass index; CESC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.1 -0.35 3.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15327300 chr17:65373795 PITPNC1 0.58 6.78 0.38 8.01e-11 Gut microbiome composition (summer); CESC cis rs8017423 0.647 rs4904673 chr14:90817338 G/A cg14092571 chr14:90743983 NA 0.44 6.62 0.38 1.93e-10 Mortality in heart failure; CESC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg24675658 chr1:53192096 ZYG11B -0.59 -7.51 -0.42 9.17e-13 Monocyte count; CESC cis rs477692 0.629 rs945231 chr10:131294827 A/G cg05714579 chr10:131428358 MGMT 0.43 5.62 0.33 4.88e-8 Response to temozolomide; CESC trans rs10488821 0.903 rs61884729 chr11:30515682 G/C cg04407762 chr4:113442791 NA -0.46 -6.76 -0.38 8.89e-11 QRS complex (12-leadsum); CESC cis rs11608355 0.545 rs4766474 chr12:109908084 G/C cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs929843 1 rs929843 chr16:70045748 A/C cg09409435 chr16:70099608 PDXDC2 1.05 11.22 0.57 3.6e-24 Menarche (age at onset); CESC cis rs2014572 0.967 rs10427146 chr19:57755998 T/C cg24459738 chr19:57751996 ZNF805 -0.54 -7.78 -0.43 1.67e-13 Hyperactive-impulsive symptoms; CESC cis rs9818758 0.556 rs116432667 chr3:48947589 C/T cg00383909 chr3:49044727 WDR6 0.95 6.8 0.39 6.82e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs2228479 0.702 rs12599561 chr16:89894358 C/G cg14709524 chr16:89940631 TCF25 0.87 6.05 0.35 4.99e-9 Skin colour saturation; CESC cis rs4455778 0.536 rs10266289 chr7:48941456 C/T cg26309511 chr7:48887640 NA -0.35 -5.13 -0.3 5.51e-7 Lung cancer in never smokers; CESC cis rs1153858 0.945 rs2467854 chr15:45701597 A/G cg21132104 chr15:45694354 SPATA5L1 0.76 10.15 0.53 1.12e-20 Homoarginine levels; CESC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg06456125 chr7:65229604 NA 0.45 5.9 0.34 1.11e-8 Aortic root size; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg21490179 chr3:40494492 NA 0.47 6.69 0.38 1.32e-10 Positive affect; CESC cis rs3806843 1.000 rs12055222 chr5:140165568 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.23 -0.31 3.52e-7 Depressive symptoms (multi-trait analysis); CESC cis rs11608355 0.545 rs11066737 chr12:109904792 A/G cg05360138 chr12:110035743 NA -0.81 -9.03 -0.48 3.74e-17 Neuroticism; CESC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg13126279 chr21:47581558 C21orf56 0.48 6.53 0.37 3.26e-10 Testicular germ cell tumor; CESC cis rs61931739 0.534 rs10844801 chr12:34230940 A/T cg19457237 chr12:34500585 NA -0.36 -5.08 -0.3 7.09e-7 Morning vs. evening chronotype; CESC cis rs72781680 0.898 rs72796171 chr2:23942667 G/C cg08917208 chr2:24149416 ATAD2B 1.0 9.21 0.49 1.03e-17 Lymphocyte counts; CESC cis rs2404602 0.692 rs12902452 chr15:76921465 T/C cg26408565 chr15:76604113 ETFA -0.39 -5.51 -0.32 8.57e-8 Blood metabolite levels; CESC cis rs12249377 0.519 rs66650915 chr10:92592468 T/C cg14313238 chr10:92632228 RPP30 0.43 5.25 0.31 3.16e-7 White matter microstructure (global fractional anisotropy); CESC cis rs1348850 0.874 rs4893822 chr2:178285727 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.8 10.45 0.54 1.22e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4595586 0.525 rs35089392 chr12:39414547 T/G cg13010199 chr12:38710504 ALG10B 0.43 5.33 0.31 2.13e-7 Morning vs. evening chronotype; CESC cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg22467129 chr15:76604101 ETFA -0.38 -5.81 -0.34 1.81e-8 Blood metabolite levels; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg02013274 chr2:28614438 FOSL2 0.46 6.19 0.36 2.29e-9 Neuroticism; CESC cis rs2276314 0.857 rs3737474 chr18:33613595 T/C cg19628046 chr18:33552617 C18orf21 0.51 5.61 0.33 5.16e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg22834771 chr12:69754056 YEATS4 -0.48 -6.48 -0.37 4.41e-10 Blood protein levels; CESC cis rs4689388 0.581 rs1801212 chr4:6302519 C/T cg14416269 chr4:6271139 WFS1 0.39 5.31 0.31 2.38e-7 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg02951883 chr7:2050386 MAD1L1 -0.48 -6.42 -0.37 6.35e-10 Bipolar disorder and schizophrenia; CESC cis rs9300255 0.602 rs1716160 chr12:123700225 C/T cg00376283 chr12:123451042 ABCB9 0.7 8.83 0.48 1.45e-16 Neutrophil percentage of white cells; CESC cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg22875332 chr1:76189707 ACADM 0.59 6.71 0.38 1.15e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2235642 0.785 rs1057983 chr16:1660274 A/G cg03771183 chr16:1608904 IFT140 0.36 5.11 0.3 6.24e-7 Coronary artery disease; CESC cis rs1670533 1.000 rs4690215 chr4:1054619 G/C cg04106633 chr4:1044584 NA 0.41 5.2 0.3 4.01e-7 Recombination rate (females); CESC cis rs9811920 0.609 rs6809988 chr3:99656615 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.61 -9.63 -0.51 5.16e-19 Axial length; CESC cis rs765787 0.530 rs1706831 chr15:45516230 T/C cg24006582 chr15:45444508 DUOX1 -0.58 -7.12 -0.4 1.04e-11 Uric acid levels; CESC cis rs9633740 0.773 rs7080009 chr10:82269461 T/C cg00277334 chr10:82204260 NA -0.58 -5.78 -0.33 2.15e-8 Post bronchodilator FEV1; CESC cis rs16854884 0.586 rs4616638 chr3:143735423 A/T cg01302019 chr3:143689584 C3orf58 0.32 5.15 0.3 5.12e-7 Economic and political preferences (feminism/equality); CESC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg11764359 chr7:65958608 NA 0.69 9.56 0.51 8.26e-19 Aortic root size; CESC trans rs11039798 1.000 rs12223271 chr11:48417420 G/C cg15704280 chr7:45808275 SEPT13 0.68 6.21 0.36 2.09e-9 Axial length; CESC cis rs13191362 0.938 rs13213746 chr6:163167777 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.66 6.92 0.39 3.46e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2180341 0.781 rs7742161 chr6:127571676 T/C cg24812749 chr6:127587940 RNF146 0.84 11.79 0.59 4.34e-26 Breast cancer; CESC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg22823121 chr1:150693482 HORMAD1 0.47 6.51 0.37 3.7e-10 Melanoma; CESC cis rs9911578 0.935 rs34523895 chr17:57034095 T/C cg12560992 chr17:57184187 TRIM37 0.81 12.8 0.62 1.55e-29 Intelligence (multi-trait analysis); CESC cis rs7665939 1.000 rs72709206 chr4:190109171 T/C cg14840187 chr4:190284988 NA -0.83 -6.89 -0.39 3.99e-11 Amyotrophic lateral sclerosis; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg25266327 chr19:16435660 KLF2 0.44 6.08 0.35 4.08e-9 Breast cancer;Type 2 diabetes; CESC cis rs2108225 0.900 rs4518594 chr7:107451060 G/C cg18560240 chr7:107437656 SLC26A3 -0.4 -5.31 -0.31 2.34e-7 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00345792 chr1:27877772 AHDC1 -0.51 -6.0 -0.35 6.37e-9 Gut microbiome composition (summer); CESC cis rs7148979 1 rs7148979 chr14:74547318 T/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.56 5.19 0.3 4.19e-7 Red cell distribution width; CESC cis rs1707322 0.964 rs7546237 chr1:46285610 A/C cg03146154 chr1:46216737 IPP 0.72 9.84 0.52 1.14e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs61931739 0.500 rs11053197 chr12:34441949 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.44 0.54 1.34e-21 Morning vs. evening chronotype; CESC cis rs4835473 0.643 rs34680080 chr4:144718443 A/C cg25736465 chr4:144833511 NA -0.36 -5.69 -0.33 3.37e-8 Immature fraction of reticulocytes; CESC trans rs7089973 0.523 rs6585311 chr10:116733575 T/C cg17463145 chr7:79084011 MAGI2 0.31 6.1 0.35 3.75e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6831352 0.918 rs29001201 chr4:100053861 T/C cg12011299 chr4:100065546 ADH4 -0.6 -6.61 -0.38 2.1e-10 Alcohol dependence; CESC cis rs400736 0.860 rs2294890 chr1:8086527 T/G cg25007680 chr1:8021821 PARK7 0.73 10.32 0.54 3.29e-21 Response to antidepressants and depression; CESC cis rs9291683 0.595 rs11731110 chr4:10037346 T/C cg11266682 chr4:10021025 SLC2A9 0.7 13.8 0.65 5.02e-33 Bone mineral density; CESC cis rs9900062 0.586 rs35018407 chr17:62690181 A/C cg02598441 chr17:62777298 LOC146880 -0.62 -6.88 -0.39 4.43e-11 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20252016 chr11:64851499 CDCA5;ZFPL1 0.66 8.04 0.44 3.03e-14 Gut microbiome composition (summer); CESC cis rs698833 0.926 rs1067399 chr2:44678648 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.72 0.33 2.82e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.41 0.46 2.54e-15 Intelligence (multi-trait analysis); CESC cis rs561341 0.709 rs11542477 chr17:30185892 A/G cg00745463 chr17:30367425 LRRC37B 0.6 5.57 0.32 6.21e-8 Hip circumference adjusted for BMI; CESC cis rs2404602 0.692 rs12911902 chr15:77053575 T/C cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC cis rs854765 0.663 rs16960744 chr17:17755259 A/G cg16928487 chr17:17741425 SREBF1 0.61 11.4 0.57 9.47e-25 Total body bone mineral density; CESC cis rs3105593 0.933 rs7174839 chr15:50889624 G/C cg08437265 chr15:50716283 USP8 0.4 5.17 0.3 4.54e-7 QT interval; CESC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg27266027 chr21:40555129 PSMG1 -0.43 -5.4 -0.32 1.46e-7 Cognitive function; CESC cis rs9902453 1.000 rs4328498 chr17:28344276 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.63 -8.02 -0.44 3.47e-14 Coffee consumption (cups per day); CESC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg12463550 chr7:65579703 CRCP -0.57 -7.32 -0.41 2.98e-12 Aortic root size; CESC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC cis rs9487051 0.714 rs7757347 chr6:109633815 G/A cg12927641 chr6:109611667 NA -0.37 -5.41 -0.32 1.4e-7 Reticulocyte fraction of red cells; CESC cis rs7267979 0.903 rs6115101 chr20:25229564 C/A cg08601574 chr20:25228251 PYGB 0.42 5.91 0.34 1.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg18769074 chr3:133464867 TF 0.29 5.08 0.3 7.13e-7 Iron status biomarkers; CESC cis rs1733410 0.504 rs11181874 chr12:37912890 C/A cg26384229 chr12:38710491 ALG10B -0.54 -7.66 -0.43 3.57e-13 Morning vs. evening chronotype; CESC cis rs561341 0.941 rs501773 chr17:30314435 T/G cg19193384 chr17:30244184 NA -0.6 -6.35 -0.36 9.57e-10 Hip circumference adjusted for BMI; CESC cis rs1152591 0.729 rs1255988 chr14:64657684 C/A cg21174375 chr14:64681225 SYNE2 0.48 6.44 0.37 5.57e-10 Atrial fibrillation; CESC cis rs116095464 0.558 rs12173244 chr5:269524 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.45 0.32 1.14e-7 Breast cancer; CESC cis rs804280 0.662 rs11784693 chr8:11610674 C/T cg26752888 chr8:11627280 NEIL2 0.58 5.73 0.33 2.77e-8 Myopia (pathological); CESC cis rs2603127 0.768 rs1348998 chr3:108485200 G/A cg03329597 chr3:108125523 MYH15 0.6 5.38 0.31 1.62e-7 Hemostatic factors and hematological phenotypes; CESC cis rs2997447 0.761 rs61776616 chr1:26455812 C/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.41 0.32 1.44e-7 QRS complex (12-leadsum); CESC cis rs6665290 0.901 rs61834001 chr1:227197411 C/T cg10327440 chr1:227177885 CDC42BPA -1.22 -33.0 -0.9 7.42e-96 Myeloid white cell count; CESC cis rs3092073 0.624 rs11696623 chr20:44580380 C/T cg27529037 chr20:44575021 PCIF1 0.63 9.61 0.51 5.92e-19 Intelligence (multi-trait analysis); CESC cis rs71403859 0.502 rs12919417 chr16:71579711 A/G cg08717414 chr16:71523259 ZNF19 0.68 6.24 0.36 1.7e-9 Post bronchodilator FEV1; CESC cis rs2996428 0.667 rs7538067 chr1:3761772 C/T cg13057898 chr1:3703894 LRRC47 0.45 6.07 0.35 4.47e-9 Red cell distribution width; CESC cis rs7267979 1.000 rs4813566 chr20:25386465 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.39e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs910316 1.000 rs4322591 chr14:75600697 C/T cg16144293 chr14:75469539 EIF2B2 -0.39 -5.13 -0.3 5.63e-7 Height; CESC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -12.59 -0.61 8.63e-29 Gut microbiome composition (summer); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg13805052 chr1:2283063 LOC100129534;MORN1 -0.42 -6.15 -0.35 2.78e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2243480 1.000 rs13220979 chr7:65363204 G/A cg12463550 chr7:65579703 CRCP 0.69 5.62 0.33 4.79e-8 Diabetic kidney disease; CESC cis rs7824557 0.591 rs2736282 chr8:11225480 C/T cg21775007 chr8:11205619 TDH 0.58 8.74 0.47 2.77e-16 Retinal vascular caliber; CESC cis rs67311347 0.956 rs6771527 chr3:40506548 T/C cg24209194 chr3:40518798 ZNF619 -0.54 -7.1 -0.4 1.13e-11 Renal cell carcinoma; CESC cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg03433033 chr1:76189801 ACADM 0.7 8.54 0.46 1.05e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg08470875 chr2:26401718 FAM59B -0.54 -6.15 -0.35 2.83e-9 Gut microbiome composition (summer); CESC cis rs12477438 0.520 rs11123766 chr2:99780915 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.41 0.69 1.09e-38 Chronic sinus infection; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg06666157 chr19:4791552 FEM1A 0.48 6.33 0.36 1.07e-9 Weight; CESC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg11663144 chr21:46675770 NA -0.65 -10.21 -0.53 7.65e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg22974920 chr21:40686053 BRWD1 -0.43 -5.21 -0.3 3.85e-7 Cognitive function; CESC cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg07636037 chr3:49044803 WDR6 1.06 18.45 0.75 1.91e-49 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11141156 chr1:15251288 KIAA1026 0.63 7.04 0.4 1.64e-11 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg00166722 chr3:10149974 C3orf24 0.48 5.92 0.34 1.01e-8 Alzheimer's disease; CESC cis rs34779708 0.931 rs2384283 chr10:35326789 G/A cg03585969 chr10:35415529 CREM 0.77 10.16 0.53 1.1e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19243777 chr12:26278767 BHLHE41 0.5 6.7 0.38 1.28e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs898097 0.841 rs8180 chr17:80901036 C/G cg10494973 chr17:80897199 TBCD -0.43 -5.11 -0.3 6.09e-7 Breast cancer; CESC cis rs1707322 0.752 rs28623463 chr1:46170758 A/C cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10876993 0.728 rs1082503 chr12:58036717 G/A cg18357645 chr12:58087776 OS9 0.59 9.2 0.49 1.09e-17 Celiac disease or Rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15092368 chr1:143270427 NA -0.46 -6.22 -0.36 1.91e-9 Gut microbiome composition (summer); CESC cis rs9894429 0.966 rs10871499 chr17:79589006 G/A cg21984481 chr17:79567631 NPLOC4 -0.49 -8.03 -0.44 3.13e-14 Eye color traits; CESC cis rs11625487 0.609 rs74063206 chr14:77981045 C/T cg20045696 chr14:77926864 AHSA1 -0.71 -5.59 -0.32 5.54e-8 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs11168351 0.591 rs4258439 chr12:48468652 A/G cg24011408 chr12:48396354 COL2A1 -0.5 -8.24 -0.45 7.74e-15 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02184819 chr13:103249272 TPP2 0.58 6.94 0.39 2.95e-11 Gut microbiome composition (summer); CESC cis rs17608059 0.566 rs6502327 chr17:13946187 T/C cg11395062 chr17:14139857 CDRT15 0.46 5.7 0.33 3.11e-8 Temperament; CESC cis rs2997447 0.846 rs55912918 chr1:26409801 C/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.61 5.22 0.31 3.57e-7 QRS complex (12-leadsum); CESC cis rs6547741 0.935 rs12615690 chr2:27851120 T/C cg27432699 chr2:27873401 GPN1 0.49 6.78 0.38 7.67e-11 Oral cavity cancer; CESC cis rs2204008 0.627 rs10878486 chr12:38148601 T/G cg26384229 chr12:38710491 ALG10B 0.74 10.58 0.55 4.66e-22 Bladder cancer; CESC cis rs1483890 0.723 rs13061189 chr3:69411453 T/C cg22125112 chr3:69402811 FRMD4B 0.39 5.24 0.31 3.3e-7 Resting heart rate; CESC cis rs7336332 0.598 rs74563672 chr13:28010660 A/G cg01674679 chr13:27998804 GTF3A -0.58 -5.34 -0.31 2.04e-7 Weight; CESC cis rs17376456 0.825 rs10061377 chr5:93174513 T/C cg21475434 chr5:93447410 FAM172A 0.82 7.32 0.41 2.97e-12 Diabetic retinopathy; CESC cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg00033643 chr7:134001901 SLC35B4 0.44 5.6 0.33 5.38e-8 Mean platelet volume; CESC cis rs9399401 0.633 rs1329705 chr6:142753338 G/A cg03128060 chr6:142623767 GPR126 0.38 6.31 0.36 1.18e-9 Chronic obstructive pulmonary disease; CESC cis rs7937682 0.737 rs663763 chr11:111422217 C/T cg22437258 chr11:111473054 SIK2 0.61 7.58 0.42 5.87e-13 Primary sclerosing cholangitis; CESC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg23161317 chr6:28129485 ZNF389 0.4 5.6 0.33 5.45e-8 Parkinson's disease; CESC cis rs7044106 0.762 rs1411158 chr9:123464804 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.15 0.53 1.2e-20 Hip circumference adjusted for BMI; CESC cis rs12912251 0.591 rs10520103 chr15:39006243 C/G cg10631289 chr15:39006617 NA 0.49 5.22 0.31 3.62e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00197636 chr8:57906363 IMPAD1 0.63 7.27 0.41 4.03e-12 Gut microbiome composition (summer); CESC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg04025307 chr7:1156635 C7orf50 0.42 5.85 0.34 1.47e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07208322 chr5:177027175 B4GALT7 0.67 7.45 0.42 1.29e-12 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs114027117 chr17:61939935 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.3 0.41 3.38e-12 Height; CESC cis rs3796352 1.000 rs34313969 chr3:52995166 A/G cg12962167 chr3:53033115 SFMBT1 0.62 5.13 0.3 5.63e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs826838 0.709 rs4882355 chr12:38721462 A/T cg26384229 chr12:38710491 ALG10B 0.57 7.96 0.44 4.99e-14 Heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11387286 chr7:35077706 DPY19L1 0.57 6.45 0.37 5.26e-10 Gut microbiome composition (summer); CESC cis rs9549367 0.713 rs4907593 chr13:113830459 C/T cg00898013 chr13:113819073 PROZ 0.46 6.93 0.39 3.13e-11 Platelet distribution width; CESC cis rs7605827 0.930 rs11680044 chr2:15607103 T/G cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs2295499 0.833 rs1913448 chr4:2708814 G/A cg08330972 chr4:2403930 ZFYVE28 -0.33 -5.54 -0.32 7.33e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg21226059 chr5:178986404 RUFY1 -0.46 -6.83 -0.39 5.77e-11 Lung cancer; CESC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg18252515 chr7:66147081 NA -0.43 -5.62 -0.33 4.9e-8 Aortic root size; CESC cis rs9911578 0.967 rs2643124 chr17:56741672 T/C cg05425664 chr17:57184151 TRIM37 -0.53 -7.36 -0.41 2.27e-12 Intelligence (multi-trait analysis); CESC cis rs9790314 1.000 rs336591 chr3:161078080 A/G cg03342759 chr3:160939853 NMD3 -0.46 -6.03 -0.35 5.48e-9 Morning vs. evening chronotype; CESC cis rs13191362 0.872 rs35672319 chr6:163245464 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.63 6.16 0.35 2.66e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1008375 0.966 rs1860591 chr4:17577329 A/G cg16339924 chr4:17578868 LAP3 0.63 8.06 0.44 2.58e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8141529 0.748 rs5762874 chr22:29269658 C/G cg15103426 chr22:29168792 CCDC117 0.61 8.04 0.44 2.98e-14 Lymphocyte counts; CESC cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg13877915 chr19:58951672 ZNF132 0.39 5.6 0.33 5.28e-8 Uric acid clearance; CESC cis rs9354308 0.933 rs2814131 chr6:66562051 T/A cg07460842 chr6:66804631 NA 0.66 7.52 0.42 8.27e-13 Metabolite levels; CESC cis rs897080 0.552 rs1068714 chr2:44634063 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs2795502 0.873 rs2077626 chr10:43410962 A/G cg20628663 chr10:43360327 NA 0.55 6.29 0.36 1.28e-9 Blood protein levels; CESC cis rs7296418 0.883 rs1727312 chr12:123642220 G/T cg05973401 chr12:123451056 ABCB9 0.53 6.86 0.39 4.86e-11 Platelet count; CESC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg22823121 chr1:150693482 HORMAD1 0.47 7.03 0.4 1.79e-11 Melanoma; CESC cis rs9457247 1.000 rs404222 chr6:167402150 G/A cg23791538 chr6:167370224 RNASET2 -0.56 -8.02 -0.44 3.42e-14 Crohn's disease; CESC cis rs10781543 0.776 rs4378078 chr9:139375962 A/G cg14019695 chr9:139328340 INPP5E 0.38 5.77 0.33 2.22e-8 Monocyte percentage of white cells; CESC cis rs1728785 0.901 rs11075687 chr16:68655894 T/C cg02972257 chr16:68554789 NA -0.67 -7.31 -0.41 3.17e-12 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19296153 chr4:1232112 CTBP1 0.45 6.16 0.35 2.72e-9 Fibrinogen levels; CESC cis rs3092073 0.624 rs34293711 chr20:44587186 C/T cg00981651 chr20:44574847 PCIF1 0.36 5.44 0.32 1.24e-7 Intelligence (multi-trait analysis); CESC cis rs34891900 0.507 rs2587084 chr22:18140644 T/G cg19898043 chr22:18121309 BCL2L13 0.58 6.87 0.39 4.45e-11 Sum neutrophil eosinophil counts; CESC cis rs151227923 1 rs151227923 chr7:155106564 C/T cg04811098 chr7:155088454 INSIG1 0.4 5.91 0.34 1.04e-8 Stem cell growth factor beta levels; CESC cis rs9486715 0.790 rs2971602 chr6:97022468 C/T cg18709589 chr6:96969512 KIAA0776 -0.47 -6.63 -0.38 1.92e-10 Headache; CESC cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg16339924 chr4:17578868 LAP3 0.65 8.49 0.46 1.47e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg06221963 chr1:154839813 KCNN3 0.4 6.17 0.35 2.55e-9 Prostate cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24304658 chr2:26950770 KCNK3 0.53 7.39 0.41 1.9e-12 Fibrinogen levels; CESC cis rs1729951 0.575 rs1682333 chr3:136688618 G/A cg04103450 chr3:136751342 NA 0.4 5.28 0.31 2.64e-7 Neuroticism; CESC cis rs9457247 0.637 rs9459846 chr6:167441023 T/G cg07741184 chr6:167504864 NA 0.34 6.01 0.35 6.21e-9 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13665852 chr10:13146898 OPTN -0.62 -7.05 -0.4 1.53e-11 Gut microbiome composition (summer); CESC cis rs9488822 0.636 rs6937104 chr6:116375302 A/G cg05304507 chr6:116381966 FRK 0.26 6.8 0.39 6.77e-11 Cholesterol, total;LDL cholesterol; CESC cis rs933688 1.000 rs985434 chr5:90744509 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 11.04 0.56 1.47e-23 Smoking behavior; CESC cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg06697600 chr4:7070879 GRPEL1 0.53 6.95 0.39 2.84e-11 Monocyte percentage of white cells; CESC cis rs6499129 1.000 rs55966046 chr16:67466726 C/A cg26727032 chr16:67993705 SLC12A4 -0.54 -5.68 -0.33 3.59e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7397814 0.558 rs4764447 chr12:9579109 C/T cg08997352 chr12:9597637 DDX12 -0.44 -5.28 -0.31 2.67e-7 IgG glycosylation; CESC cis rs2718058 0.519 rs2598072 chr7:37875319 A/C cg15028436 chr7:37888078 TXNDC3 0.57 7.76 0.43 1.9e-13 Alzheimer's disease (late onset); CESC cis rs752092 1.000 rs11247277 chr15:101784664 A/G cg19997662 chr15:101784653 CHSY1 -0.57 -7.76 -0.43 1.81e-13 Corneal structure; CESC cis rs11098499 0.863 rs6534141 chr4:120485223 A/T cg24375607 chr4:120327624 NA 0.44 5.38 0.31 1.6e-7 Corneal astigmatism; CESC cis rs4808199 0.895 rs8105984 chr19:19374068 T/C cg03709012 chr19:19516395 GATAD2A 1.09 11.63 0.58 1.52e-25 Nonalcoholic fatty liver disease; CESC trans rs4424809 0.614 rs17078995 chr13:85572394 G/A cg05918002 chr17:5019452 ZNF232 -0.63 -6.08 -0.35 4.29e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6430585 0.527 rs12467569 chr2:136413847 T/C cg07169764 chr2:136633963 MCM6 1.06 12.14 0.6 2.95e-27 Corneal structure; CESC cis rs1062177 1.000 rs62394155 chr5:151248069 G/A cg12924095 chr5:151150029 G3BP1 0.47 5.97 0.34 7.46e-9 Preschool internalizing problems; CESC cis rs9303401 0.614 rs12948536 chr17:56580413 G/T cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.14 0.6 2.94e-27 Cognitive test performance; CESC cis rs7072216 0.763 rs2274243 chr10:100175267 T/C cg26618903 chr10:100175079 PYROXD2 -0.38 -5.85 -0.34 1.41e-8 Metabolite levels; CESC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg25405998 chr7:65216604 CCT6P1 -0.45 -5.06 -0.3 7.71e-7 Aortic root size; CESC cis rs1577917 0.629 rs7761762 chr6:86205968 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.48 7.02 0.4 1.91e-11 Response to antipsychotic treatment; CESC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.8 0.48 1.77e-16 Bipolar disorder; CESC cis rs10861342 1.000 rs10861350 chr12:105484913 G/A cg23923672 chr12:105501055 KIAA1033 0.71 5.31 0.31 2.29e-7 IgG glycosylation; CESC trans rs61931739 0.500 rs34167298 chr12:34534338 G/A cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg22467129 chr15:76604101 ETFA -0.39 -6.12 -0.35 3.39e-9 Blood metabolite levels; CESC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg11764359 chr7:65958608 NA -0.78 -11.43 -0.57 7.35e-25 Aortic root size; CESC cis rs1499614 1.000 rs1267818 chr7:66107024 C/T cg13147721 chr7:65941812 NA -0.91 -8.45 -0.46 1.99e-15 Gout; CESC cis rs9859260 0.744 rs539816 chr3:195784076 T/A cg12923728 chr3:195709715 SDHAP1 0.54 6.96 0.39 2.68e-11 Mean corpuscular volume; CESC cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg22307029 chr19:49891270 CCDC155 0.55 6.0 0.35 6.6e-9 Multiple sclerosis; CESC cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.38 -6.41 -0.37 6.46e-10 Hemoglobin concentration; CESC cis rs4975709 0.686 rs2307118 chr5:1881916 A/C cg12288994 chr5:1860383 NA 0.36 5.71 0.33 3.07e-8 Cardiovascular disease risk factors; CESC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg13777783 chr17:79615861 NA -0.37 -6.2 -0.36 2.14e-9 Eye color traits; CESC cis rs2228479 0.702 rs11649501 chr16:89850957 A/T cg00800038 chr16:89945340 TCF25 -0.91 -7.52 -0.42 8.29e-13 Skin colour saturation; CESC cis rs9549367 0.577 rs513479 chr13:113815200 C/T cg18105134 chr13:113819100 PROZ -0.77 -8.58 -0.47 8.02e-16 Platelet distribution width; CESC cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 5.67 0.33 3.81e-8 Colorectal cancer; CESC cis rs1348850 0.914 rs8941 chr2:178406481 C/T cg22681709 chr2:178499509 PDE11A -0.41 -5.92 -0.34 1e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11153306 0.552 rs12196381 chr6:111939400 A/C cg22127309 chr6:111907043 TRAF3IP2 0.43 6.52 0.37 3.57e-10 Tonsillectomy; CESC cis rs1538970 0.504 rs3790585 chr1:46023356 A/T cg03146154 chr1:46216737 IPP 0.66 7.03 0.4 1.77e-11 Platelet count; CESC cis rs2274273 0.624 rs8003279 chr14:55864130 A/G cg04306507 chr14:55594613 LGALS3 0.3 5.25 0.31 3.19e-7 Protein biomarker; CESC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.5 -6.67 -0.38 1.5e-10 Menarche (age at onset); CESC cis rs1577917 0.958 rs12665542 chr6:86544443 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.19 -0.36 2.23e-9 Response to antipsychotic treatment; CESC cis rs9457247 0.765 rs6904946 chr6:167433948 C/T cg23791538 chr6:167370224 RNASET2 0.54 7.5 0.42 9.9e-13 Crohn's disease; CESC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.51 -6.42 -0.37 6.18e-10 Prudent dietary pattern; CESC cis rs7582720 1.000 rs6723704 chr2:203738664 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs61931739 0.517 rs1817760 chr12:34106060 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.18 0.45 1.17e-14 Morning vs. evening chronotype; CESC cis rs7264396 0.709 rs2425073 chr20:34293699 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.61 0.42 4.66e-13 Total cholesterol levels; CESC cis rs4699052 0.625 rs11734836 chr4:104253203 G/A cg16532752 chr4:104119610 CENPE -0.39 -5.47 -0.32 1.02e-7 Testicular germ cell tumor; CESC cis rs1559088 1.000 rs1559088 chr19:33551061 C/T cg27124370 chr19:33622961 WDR88 0.43 5.37 0.31 1.71e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6815814 0.898 rs5743562 chr4:38806096 T/C cg02016764 chr4:38805732 TLR1 -0.63 -7.26 -0.41 4.22e-12 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01136232 chr1:25756842 TMEM57 0.45 6.8 0.39 6.84e-11 Gambling; CESC cis rs9486719 0.843 rs976357 chr6:96849679 C/T cg18709589 chr6:96969512 KIAA0776 0.55 5.67 0.33 3.72e-8 Migraine;Coronary artery disease; CESC cis rs7560272 0.538 rs11126415 chr2:73936500 C/T cg20560298 chr2:73613845 ALMS1 0.42 5.8 0.34 1.87e-8 Schizophrenia; CESC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg08888203 chr3:10149979 C3orf24 0.45 5.91 0.34 1.06e-8 Alzheimer's disease; CESC cis rs17826219 0.714 rs11650821 chr17:28968150 T/C cg13385521 chr17:29058706 SUZ12P 0.75 5.43 0.32 1.27e-7 Body mass index; CESC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg23281280 chr6:28129359 ZNF389 0.4 5.95 0.34 8.58e-9 Cardiac Troponin-T levels; CESC cis rs523522 0.962 rs7471 chr12:120941215 T/C cg27279351 chr12:120934652 DYNLL1 0.69 9.07 0.49 2.84e-17 High light scatter reticulocyte count; CESC cis rs782590 0.764 rs2586970 chr2:55829967 A/G cg18811423 chr2:55921094 PNPT1 0.77 12.1 0.6 4.01e-27 Metabolic syndrome; CESC cis rs561341 0.882 rs563539 chr17:30307958 A/G cg19193384 chr17:30244184 NA -0.59 -6.17 -0.35 2.51e-9 Hip circumference adjusted for BMI; CESC cis rs4561483 0.743 rs28653099 chr16:12009150 C/A cg08843971 chr16:11963173 GSPT1 0.46 6.45 0.37 5.31e-10 Testicular germ cell tumor; CESC cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg18305652 chr10:134549665 INPP5A 0.49 7.17 0.4 7.3e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4727027 0.901 rs66800495 chr7:148763702 T/C cg23158103 chr7:148848205 ZNF398 -0.41 -6.47 -0.37 4.66e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4973397 0.765 rs13025087 chr2:232264914 A/C cg09339159 chr2:232260559 B3GNT7 -0.56 -5.85 -0.34 1.47e-8 Anti-saccade response; CESC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 6.02 0.35 5.85e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9630089 0.746 rs4919084 chr10:98967596 G/A cg25902810 chr10:99078978 FRAT1 0.56 7.86 0.43 9.47e-14 Neutrophil percentage of white cells; CESC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.2 -0.36 2.21e-9 Parkinson's disease; CESC cis rs796364 0.906 rs281784 chr2:200749749 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.92 8.92 0.48 8.06e-17 Schizophrenia; CESC cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg10523679 chr1:76189770 ACADM 0.76 9.99 0.52 3.63e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7666738 0.830 rs13116691 chr4:98929771 A/C cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs2050392 0.517 rs2771242 chr10:30762973 C/T cg18806716 chr10:30721971 MAP3K8 -0.57 -8.75 -0.47 2.46e-16 Inflammatory bowel disease; CESC cis rs12079745 0.793 rs12740226 chr1:169183257 T/C cg09363564 chr1:169337483 NME7;BLZF1 -1.0 -6.14 -0.35 3e-9 QT interval; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17854747 chr18:29672535 RNF138 0.48 6.22 0.36 1.94e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17465697 chr1:228594029 TRIM11 0.65 7.53 0.42 7.92e-13 Gut microbiome composition (summer); CESC cis rs864537 0.676 rs2988279 chr1:167419839 G/A cg09179987 chr1:167433047 CD247 0.5 7.45 0.42 1.35e-12 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg19592336 chr6:28129416 ZNF389 0.61 8.24 0.45 8.13e-15 Depression; CESC cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg12386194 chr3:101231763 SENP7 -0.52 -5.82 -0.34 1.68e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11608355 0.545 rs2302704 chr12:109898797 A/G cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs477692 0.569 rs871028 chr10:131293478 C/T cg05714579 chr10:131428358 MGMT -0.4 -5.42 -0.32 1.33e-7 Response to temozolomide; CESC cis rs9818941 1.000 rs7429574 chr3:157703589 G/A cg08654915 chr3:157813417 NA -0.47 -7.83 -0.43 1.19e-13 Height; CESC cis rs16854884 0.586 rs7634145 chr3:143754150 G/A cg06585982 chr3:143692056 C3orf58 0.5 6.84 0.39 5.62e-11 Economic and political preferences (feminism/equality); CESC cis rs6942756 0.806 rs2718096 chr7:128951000 A/G cg02491457 chr7:128862824 NA 0.61 8.58 0.47 8.12e-16 White matter hyperintensity burden; CESC cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg10523679 chr1:76189770 ACADM -0.61 -6.16 -0.35 2.75e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2652822 1.000 rs1126308 chr15:63429086 G/T cg02713581 chr15:63449717 RPS27L -0.57 -7.42 -0.41 1.58e-12 Metabolic traits; CESC cis rs11098499 0.865 rs9994730 chr4:120381564 A/C cg09307838 chr4:120376055 NA 0.93 12.99 0.62 3.33e-30 Corneal astigmatism; CESC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg25036284 chr2:26402008 FAM59B -0.59 -6.83 -0.39 5.71e-11 Gut microbiome composition (summer); CESC cis rs1008375 0.902 rs12503164 chr4:17656107 C/T cg02297831 chr4:17616191 MED28 0.53 6.7 0.38 1.24e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg13770153 chr20:60521292 NA -0.44 -5.63 -0.33 4.53e-8 Body mass index; CESC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg18099408 chr3:52552593 STAB1 -0.32 -5.19 -0.3 4.2e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03809994 chr4:75023664 MTHFD2L 0.61 7.04 0.4 1.66e-11 Gut microbiome composition (summer); CESC cis rs4835473 0.932 rs4240334 chr4:144792505 G/A cg25736465 chr4:144833511 NA 0.44 6.58 0.37 2.48e-10 Immature fraction of reticulocytes; CESC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg17221315 chr6:27791827 HIST1H4J 0.42 5.4 0.32 1.46e-7 Parkinson's disease; CESC cis rs13242816 1.000 rs34424131 chr7:116119002 G/A cg04696780 chr7:116139425 CAV2 -0.58 -5.15 -0.3 5.21e-7 P wave duration; CESC cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC cis rs962856 0.619 rs4671181 chr2:67604847 T/C cg09028215 chr2:67624308 ETAA1 -0.42 -5.1 -0.3 6.56e-7 Pancreatic cancer; CESC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg02398342 chr17:80708632 TBCD;FN3K 0.42 5.12 0.3 5.86e-7 Glycated hemoglobin levels; CESC cis rs6912958 0.525 rs586771 chr6:88064971 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.88 0.56 4.8e-23 Monocyte percentage of white cells; CESC cis rs2832191 0.636 rs8131283 chr21:30516796 A/G cg08807101 chr21:30365312 RNF160 -0.56 -6.39 -0.37 7.28e-10 Dental caries; CESC cis rs743757 1.000 rs2282754 chr3:50436827 T/C cg05260129 chr3:50388622 TUSC4;CYB561D2 0.45 5.06 0.3 8e-7 Diastolic blood pressure; CESC cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg26408565 chr15:76604113 ETFA -0.43 -6.25 -0.36 1.65e-9 Blood metabolite levels; CESC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.12 0.4 1.02e-11 Depression; CESC cis rs7666738 0.830 rs35644814 chr4:98886111 G/C cg05340658 chr4:99064831 C4orf37 0.74 10.96 0.56 2.72e-23 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg17427002 chr7:12443146 VWDE -0.58 -6.01 -0.35 6.16e-9 Coronary artery disease; CESC cis rs10751667 0.666 rs10902249 chr11:958566 C/T cg06064525 chr11:970664 AP2A2 0.49 9.71 0.51 2.81e-19 Alzheimer's disease (late onset); CESC cis rs1401999 0.690 rs1402001 chr3:183642751 A/G cg01324343 chr3:183735012 ABCC5 0.45 8.84 0.48 1.32e-16 Anterior chamber depth; CESC cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg02297831 chr4:17616191 MED28 0.5 6.15 0.35 2.82e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9435341 0.762 rs2878349 chr1:107549245 G/A cg09367891 chr1:107599246 PRMT6 0.6 6.6 0.38 2.24e-10 Facial morphology (factor 21, depth of nasal alae); CESC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs1559088 0.847 rs6510348 chr19:33601946 G/A cg17764715 chr19:33622953 WDR88 0.48 6.2 0.36 2.2e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg24531977 chr5:56204891 C5orf35 -0.56 -7.02 -0.4 1.81e-11 Coronary artery disease; CESC cis rs6537837 1.000 rs7537507 chr1:110131105 G/A cg05049280 chr1:110155535 GNAT2 0.39 5.29 0.31 2.55e-7 Major depressive disorder; CESC cis rs2404602 0.692 rs1116535 chr15:77009514 C/G cg22467129 chr15:76604101 ETFA 0.35 5.34 0.31 1.98e-7 Blood metabolite levels; CESC cis rs7116495 0.609 rs73543640 chr11:71834374 G/T cg10381502 chr11:71823885 C11orf51 1.06 6.77 0.38 8.27e-11 Severe influenza A (H1N1) infection; CESC cis rs11958404 0.932 rs6870115 chr5:157436960 T/C cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs9487051 0.502 rs9386781 chr6:109584520 G/A cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs2933343 0.679 rs789221 chr3:128591625 A/G cg25356066 chr3:128598488 ACAD9 0.56 7.83 0.43 1.15e-13 IgG glycosylation; CESC cis rs6429082 0.902 rs704708 chr1:235620134 T/C cg26050004 chr1:235667680 B3GALNT2 0.4 5.03 0.3 9.03e-7 Adiposity; CESC cis rs2742234 0.541 rs11528481 chr10:43737767 C/A cg15436174 chr10:43711423 RASGEF1A 0.45 5.13 0.3 5.72e-7 Hirschsprung disease; CESC cis rs897984 0.721 rs4889525 chr16:30989858 T/C cg02466173 chr16:30829666 NA 0.47 7.96 0.44 4.96e-14 Dementia with Lewy bodies; CESC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg26314531 chr2:26401878 FAM59B 0.85 9.23 0.49 8.65e-18 Gut microbiome composition (summer); CESC cis rs28489187 0.706 rs233115 chr1:85786977 G/A cg16011679 chr1:85725395 C1orf52 0.49 5.77 0.33 2.15e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg08027265 chr7:2291960 NA -0.34 -5.08 -0.3 7.23e-7 Bipolar disorder and schizophrenia; CESC cis rs4835473 0.932 rs12512202 chr4:144692401 A/G cg25736465 chr4:144833511 NA -0.33 -5.15 -0.3 5e-7 Immature fraction of reticulocytes; CESC cis rs9787249 0.957 rs11206754 chr1:40216234 A/G cg24920358 chr1:40204285 PPIE 0.45 6.68 0.38 1.43e-10 Blood protein levels; CESC cis rs6460942 1.000 rs77010200 chr7:12290724 G/A cg06484146 chr7:12443880 VWDE -0.77 -8.09 -0.45 2.1e-14 Coronary artery disease; CESC trans rs1814175 0.817 rs10769648 chr11:50013992 T/C cg03929089 chr4:120376271 NA -0.94 -16.01 -0.7 7.75e-41 Height; CESC cis rs9796 0.621 rs11858678 chr15:41467932 A/G cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.61 -0.38 2.06e-10 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01320780 chr8:22298453 PPP3CC 0.54 6.21 0.36 2.02e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04363097 chr16:74330294 PSMD7 -0.59 -6.99 -0.39 2.24e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.49 6.03 0.35 5.48e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26149728 chr3:119182545 TMEM39A 0.59 6.43 0.37 5.89e-10 Gut microbiome composition (summer); CESC cis rs11785400 1.000 rs7002932 chr8:143738816 C/A cg24634471 chr8:143751801 JRK 0.47 6.21 0.36 2e-9 Schizophrenia; CESC cis rs6674176 0.593 rs3791120 chr1:44431715 T/C cg13606994 chr1:44402422 ARTN -0.39 -5.79 -0.34 1.96e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7927771 1.000 rs10838738 chr11:47663049 A/G cg20307385 chr11:47447363 PSMC3 -0.49 -5.9 -0.34 1.11e-8 Subjective well-being; CESC cis rs2204008 0.715 rs11514342 chr12:38236710 T/A cg13010199 chr12:38710504 ALG10B 0.49 6.1 0.35 3.78e-9 Bladder cancer; CESC cis rs863345 0.967 rs1117124 chr1:158509851 G/C cg12129480 chr1:158549410 OR10X1 -0.32 -6.37 -0.36 8.16e-10 Pneumococcal bacteremia; CESC cis rs11077998 0.935 rs11653926 chr17:80484953 G/A cg20173014 chr17:80541737 FOXK2 -0.32 -5.07 -0.3 7.37e-7 Reticulocyte fraction of red cells; CESC cis rs7927771 0.507 rs11039432 chr11:47873327 G/A cg20307385 chr11:47447363 PSMC3 0.61 8.55 0.47 9.73e-16 Subjective well-being; CESC cis rs17376456 0.877 rs10076052 chr5:93317762 C/T cg21475434 chr5:93447410 FAM172A 0.76 6.88 0.39 4.31e-11 Diabetic retinopathy; CESC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg18301423 chr5:131593218 PDLIM4 0.38 5.44 0.32 1.21e-7 Breast cancer; CESC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.55 0.37 2.91e-10 Prudent dietary pattern; CESC cis rs28374715 0.662 rs521890 chr15:41473143 C/T cg18705301 chr15:41695430 NDUFAF1 -0.74 -9.83 -0.52 1.25e-19 Ulcerative colitis; CESC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg19163074 chr7:65112434 INTS4L2 0.4 5.07 0.3 7.58e-7 Aortic root size; CESC cis rs9815354 0.812 rs73081321 chr3:41890231 G/A cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.84e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9479482 0.935 rs563278 chr6:150364427 G/C cg03788504 chr6:150331562 NA -0.34 -6.4 -0.37 7.1e-10 Alopecia areata; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16550438 chr11:64112387 CCDC88B -0.56 -6.38 -0.36 7.84e-10 Gut microbiome composition (summer); CESC cis rs9309473 0.519 rs2421584 chr2:73898852 G/A cg20560298 chr2:73613845 ALMS1 0.53 7.32 0.41 3.04e-12 Metabolite levels; CESC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg24578937 chr1:2090814 PRKCZ -0.35 -5.97 -0.34 7.43e-9 Height; CESC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg11247378 chr22:39784982 NA -0.63 -9.73 -0.51 2.44e-19 Intelligence (multi-trait analysis); CESC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg07677032 chr17:61819896 STRADA 0.42 5.35 0.31 1.92e-7 Height; CESC cis rs2070997 0.548 rs7868336 chr9:133668926 T/C cg11464064 chr9:133710261 ABL1 0.5 5.75 0.33 2.48e-8 Response to amphetamines; CESC cis rs9302635 0.513 rs8061459 chr16:72156063 C/T cg01557791 chr16:72042693 DHODH -0.57 -6.65 -0.38 1.66e-10 Blood protein levels; CESC cis rs2718058 0.639 rs2718036 chr7:37775288 T/A cg24998770 chr7:37888106 TXNDC3 0.36 5.41 0.32 1.42e-7 Alzheimer's disease (late onset); CESC cis rs5753618 0.561 rs4820963 chr22:31698166 C/T cg00478049 chr22:31556069 RNF185 0.45 5.07 0.3 7.58e-7 Colorectal cancer; CESC trans rs1814175 0.817 rs1988416 chr11:49932324 G/A cg03929089 chr4:120376271 NA -0.93 -16.26 -0.71 1.03e-41 Height; CESC cis rs6540556 0.769 rs6540552 chr1:209927710 C/T cg05527609 chr1:210001259 C1orf107 0.51 6.17 0.35 2.55e-9 Red blood cell count; CESC cis rs7605827 0.930 rs6733647 chr2:15542159 A/G cg19274914 chr2:15703543 NA 0.38 6.87 0.39 4.61e-11 Educational attainment (years of education); CESC cis rs916888 0.687 rs199456 chr17:44797919 C/T cg01570182 chr17:44337453 NA 0.94 10.66 0.55 2.65e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07213289 chr7:73610504 EIF4H -0.65 -7.97 -0.44 4.8e-14 Gut microbiome composition (summer); CESC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg11366901 chr6:160182831 ACAT2 0.82 10.46 0.54 1.12e-21 Age-related macular degeneration (geographic atrophy); CESC cis rs561341 0.882 rs28649357 chr17:30367190 A/G cg12193833 chr17:30244370 NA -0.49 -5.04 -0.3 8.66e-7 Hip circumference adjusted for BMI; CESC cis rs9902453 0.838 rs8064689 chr17:28217053 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.13 0.45 1.68e-14 Coffee consumption (cups per day); CESC trans rs12229918 0.540 rs10784460 chr12:65863584 C/T cg24879327 chr17:8191805 RANGRF;SLC25A35 0.51 6.32 0.36 1.12e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CESC cis rs3820068 0.705 rs4646092 chr1:15821673 C/T cg18192808 chr1:15853278 DNAJC16 0.47 5.78 0.33 2.05e-8 Systolic blood pressure; CESC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg25072359 chr17:41440525 NA 0.43 5.79 0.34 1.98e-8 Menopause (age at onset); CESC cis rs7582720 1.000 rs72936873 chr2:203791333 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6669072 0.669 rs712031 chr1:91243395 A/G cg08895590 chr1:91227319 NA -0.33 -5.65 -0.33 4.2e-8 Cognitive function; CESC cis rs7301826 0.651 rs6486601 chr12:131301237 A/T cg11011512 chr12:131303247 STX2 -0.44 -5.28 -0.31 2.65e-7 Plasma plasminogen activator levels; CESC cis rs67311347 0.577 rs11129870 chr3:40260406 G/A cg09455208 chr3:40491958 NA 0.35 5.5 0.32 8.99e-8 Renal cell carcinoma; CESC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg22535103 chr8:58192502 C8orf71 -0.86 -8.78 -0.47 2.07e-16 Developmental language disorder (linguistic errors); CESC cis rs425277 1.000 rs436045 chr1:2071556 A/G cg16545954 chr1:2118288 C1orf86 -0.32 -5.46 -0.32 1.1e-7 Height; CESC cis rs539096 0.500 rs2367804 chr1:44314266 C/T cg13606994 chr1:44402422 ARTN -0.37 -5.71 -0.33 2.97e-8 Intelligence (multi-trait analysis); CESC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg07677032 chr17:61819896 STRADA 0.43 5.64 0.33 4.44e-8 Height; CESC cis rs400736 0.930 rs442862 chr1:8079494 T/C cg25007680 chr1:8021821 PARK7 0.71 10.26 0.53 5.13e-21 Response to antidepressants and depression; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17961057 chr2:74645699 C2orf81 -0.44 -6.09 -0.35 3.85e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02471486 chr8:71016278 NA -0.63 -7.5 -0.42 9.68e-13 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs10142757 chr14:56074211 C/A cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs6570726 0.935 rs377130 chr6:145836632 C/T cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs7833986 0.534 rs2976022 chr8:57007843 T/G cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.54 0.42 7.58e-13 Height; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg17193163 chr11:66056724 YIF1A -0.46 -6.08 -0.35 4.24e-9 Recombination measurement; CESC cis rs6426558 0.537 rs12039370 chr1:227326472 A/G cg10327440 chr1:227177885 CDC42BPA -0.47 -5.9 -0.34 1.13e-8 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02861082 chr2:136633712 MCM6 0.67 8.32 0.46 4.62e-15 Gut microbiome composition (summer); CESC cis rs2559856 1.000 rs2695286 chr12:102088507 T/C cg15068132 chr12:102092402 CHPT1 -0.42 -5.59 -0.32 5.57e-8 Blood protein levels; CESC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg02569458 chr12:86230093 RASSF9 -0.46 -6.96 -0.39 2.62e-11 Major depressive disorder; CESC cis rs9790314 1.000 rs4350933 chr3:160955879 G/T cg03342759 chr3:160939853 NMD3 -0.53 -7.32 -0.41 3.03e-12 Morning vs. evening chronotype; CESC cis rs7917772 0.503 rs11191321 chr10:104293412 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.33 0.41 2.81e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.55 5.24 0.31 3.23e-7 Lung cancer in ever smokers; CESC cis rs4237845 0.837 rs7954591 chr12:58299037 A/G cg00677455 chr12:58241039 CTDSP2 0.43 5.62 0.33 4.88e-8 Intelligence (multi-trait analysis); CESC cis rs250677 0.958 rs17109282 chr5:148416677 A/G cg18129178 chr5:148520854 ABLIM3 0.47 5.5 0.32 8.97e-8 Breast cancer; CESC cis rs881375 0.678 rs10739581 chr9:123696871 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.48 0.32 9.71e-8 Rheumatoid arthritis; CESC cis rs2486288 0.586 rs12909625 chr15:45572053 C/A cg09092052 chr15:45571596 NA 0.44 5.23 0.31 3.44e-7 Glomerular filtration rate; CESC cis rs12477438 0.734 rs4851184 chr2:99666434 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs447 1.000 rs7785708 chr7:83752668 C/T cg22846510 chr7:83753280 SEMA3A -0.46 -5.74 -0.33 2.55e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9911578 0.967 rs7502208 chr17:57165097 G/A cg12560992 chr17:57184187 TRIM37 1.0 17.6 0.73 1.84e-46 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03532930 chr1:2246464 NA -0.45 -6.21 -0.36 2e-9 Fibrinogen levels; CESC cis rs1005277 0.540 rs1987431 chr10:37988887 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -9.67 -0.51 3.72e-19 Extrinsic epigenetic age acceleration; CESC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg05313129 chr8:58192883 C8orf71 -0.58 -6.61 -0.38 2.12e-10 Developmental language disorder (linguistic errors); CESC trans rs561341 1.000 rs484175 chr17:30309041 G/A cg27661571 chr11:113659931 NA -0.83 -7.76 -0.43 1.9e-13 Hip circumference adjusted for BMI; CESC cis rs2204008 0.715 rs12368462 chr12:38336116 C/G cg13010199 chr12:38710504 ALG10B 0.47 6.02 0.35 5.71e-9 Bladder cancer; CESC cis rs7259376 0.840 rs8106611 chr19:22569618 G/A cg02657401 chr19:22469223 NA -0.26 -5.14 -0.3 5.39e-7 Menopause (age at onset); CESC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg20573242 chr4:122745356 CCNA2 0.62 7.47 0.42 1.14e-12 Type 2 diabetes; CESC trans rs7335046 0.901 rs72649510 chr13:99957621 C/T cg08418111 chr11:18433745 LDHC 0.61 5.99 0.35 6.68e-9 Basal cell carcinoma; CESC cis rs116095464 0.558 rs55664502 chr5:270485 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.27 0.31 2.77e-7 Breast cancer; CESC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg07308232 chr7:1071921 C7orf50 0.64 9.02 0.48 3.84e-17 Longevity;Endometriosis; CESC cis rs7246657 0.943 rs10404602 chr19:37825633 A/T cg23950597 chr19:37808831 NA -0.62 -6.26 -0.36 1.56e-9 Coronary artery calcification; CESC cis rs10743315 0.732 rs71539461 chr12:19443360 G/A cg02471346 chr12:19282374 PLEKHA5 0.56 5.03 0.3 9.2e-7 Gut microbiota (bacterial taxa); CESC cis rs4077515 0.901 rs3812573 chr9:139276680 C/T cg14169450 chr9:139327907 INPP5E 0.38 5.41 0.32 1.39e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs858239 0.896 rs1637192 chr7:23260514 G/A cg23682824 chr7:23144976 KLHL7 0.43 5.68 0.33 3.58e-8 Cerebrospinal fluid biomarker levels; CESC trans rs2727020 1.000 rs2727020 chr11:49111407 C/G cg03929089 chr4:120376271 NA 0.71 9.32 0.5 4.8e-18 Coronary artery disease; CESC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg00484396 chr16:3507460 NAT15 0.43 6.91 0.39 3.52e-11 Tuberculosis; CESC cis rs10875746 0.768 rs4760609 chr12:48415757 A/C cg24011408 chr12:48396354 COL2A1 0.41 5.43 0.32 1.25e-7 Longevity (90 years and older); CESC cis rs5769765 0.773 rs138834 chr22:50180497 A/C cg02269571 chr22:50332266 NA -0.53 -6.17 -0.35 2.57e-9 Schizophrenia; CESC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg18758796 chr5:131593413 PDLIM4 0.45 6.23 0.36 1.79e-9 Breast cancer; CESC cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg00825309 chr19:58991885 ZNF446 -0.84 -13.5 -0.64 5.78e-32 Mean platelet volume; CESC trans rs9467711 0.659 rs13220261 chr6:26499185 C/T cg01620082 chr3:125678407 NA -0.8 -6.23 -0.36 1.86e-9 Autism spectrum disorder or schizophrenia; CESC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg21724239 chr8:58056113 NA 0.59 5.24 0.31 3.25e-7 Developmental language disorder (linguistic errors); CESC cis rs2075371 0.829 rs35897155 chr7:134002711 G/A cg11752832 chr7:134001865 SLC35B4 0.5 6.31 0.36 1.15e-9 Mean platelet volume; CESC cis rs7666738 0.830 rs13125930 chr4:98654695 G/A cg17366294 chr4:99064904 C4orf37 0.56 7.61 0.42 4.87e-13 Colonoscopy-negative controls vs population controls; CESC cis rs2979489 0.945 rs34960391 chr8:30332723 G/A cg26383811 chr8:30366931 RBPMS -0.84 -9.93 -0.52 5.8e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg24562669 chr7:97807699 LMTK2 0.52 7.7 0.43 2.78e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs7762018 0.607 rs79355059 chr6:170062157 T/C cg19338460 chr6:170058176 WDR27 -0.95 -7.81 -0.43 1.35e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg24549020 chr5:56110836 MAP3K1 0.41 5.08 0.3 7.24e-7 Coronary artery disease; CESC cis rs28498503 1.000 rs7238348 chr18:76660408 C/T cg00806245 chr18:76673096 NA -0.7 -5.83 -0.34 1.58e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs1670533 1.000 rs7660779 chr4:1075940 A/G cg04106633 chr4:1044584 NA 0.41 5.17 0.3 4.72e-7 Recombination rate (females); CESC cis rs4654899 0.802 rs10737452 chr1:21199764 C/T cg05370193 chr1:21551575 ECE1 -0.35 -5.25 -0.31 3.09e-7 Superior frontal gyrus grey matter volume; CESC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.89 0.52 7.86e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04892391 chr12:105478345 ALDH1L2 0.52 6.05 0.35 4.94e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01849260 chr5:77072153 TBCA -0.45 -6.18 -0.35 2.37e-9 Fibrinogen levels; CESC cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.29 0.31 2.6e-7 Electroencephalogram traits; CESC cis rs9916302 0.821 rs4795386 chr17:37746847 A/G cg20243544 chr17:37824526 PNMT 0.57 6.99 0.39 2.29e-11 Glomerular filtration rate (creatinine); CESC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg26939375 chr7:64535504 NA 0.48 6.11 0.35 3.47e-9 Aortic root size; CESC cis rs67478160 0.572 rs8016014 chr14:104293798 G/C cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.04 -0.4 1.62e-11 Schizophrenia; CESC cis rs9309473 1.000 rs58603761 chr2:73726605 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.14 -0.35 2.97e-9 Metabolite levels; CESC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs7937682 0.855 rs10891285 chr11:111527775 T/C cg22437258 chr11:111473054 SIK2 0.69 9.25 0.49 7.9e-18 Primary sclerosing cholangitis; CESC cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 8.77 0.47 2.28e-16 Hip circumference adjusted for BMI; CESC cis rs763121 0.853 rs2072798 chr22:39148483 G/A cg06022373 chr22:39101656 GTPBP1 0.93 15.87 0.7 2.44e-40 Menopause (age at onset); CESC cis rs6754311 0.550 rs1438307 chr2:136499166 A/C cg07169764 chr2:136633963 MCM6 0.7 9.05 0.49 3.22e-17 Mosquito bite size; CESC cis rs748404 0.723 rs573169 chr15:43550581 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.96 0.44 5.16e-14 Lung cancer; CESC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg13628971 chr7:2884303 GNA12 0.67 9.08 0.49 2.53e-17 Height; CESC cis rs1550582 0.917 rs7831961 chr8:135507060 C/G cg17885191 chr8:135476712 NA -0.7 -8.95 -0.48 6.29e-17 Educational attainment; CESC trans rs9467711 0.606 rs9379901 chr6:26603866 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.73 6.12 0.35 3.38e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2712184 0.756 rs2024487 chr2:217663271 C/T cg05032264 chr2:217675019 NA 0.36 5.4 0.31 1.5e-7 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC cis rs12822507 0.708 rs10845597 chr12:12782068 G/A cg11838227 chr12:12764436 CREBL2 0.42 5.64 0.33 4.37e-8 Systemic lupus erythematosus; CESC cis rs7666738 0.822 rs28367231 chr4:98845726 G/T cg05340658 chr4:99064831 C4orf37 0.71 10.18 0.53 9.15e-21 Colonoscopy-negative controls vs population controls; CESC cis rs1832871 0.672 rs7750011 chr6:158746802 A/C cg07165851 chr6:158734300 TULP4 0.59 6.41 0.37 6.63e-10 Height; CESC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg09467607 chr2:36825704 FEZ2 -0.61 -11.77 -0.59 5.06e-26 Height; CESC cis rs7116495 0.609 rs10898812 chr11:71698801 G/A cg07596299 chr11:71824057 C11orf51 -0.85 -5.48 -0.32 9.86e-8 Severe influenza A (H1N1) infection; CESC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.44 6.52 0.37 3.58e-10 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00945486 chr8:139890004 COL22A1 0.36 6.12 0.35 3.43e-9 Fibrinogen levels; CESC cis rs7829975 0.660 rs10093926 chr8:8549020 A/C cg06636001 chr8:8085503 FLJ10661 -0.45 -5.85 -0.34 1.47e-8 Mood instability; CESC cis rs7512552 0.809 rs828783 chr1:150376977 C/T cg15654264 chr1:150340011 RPRD2 0.39 5.18 0.3 4.3e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs9486719 0.857 rs2971606 chr6:97043025 C/G cg06623918 chr6:96969491 KIAA0776 -0.88 -10.63 -0.55 3.13e-22 Migraine;Coronary artery disease; CESC cis rs1144333 0.850 rs1144342 chr1:76284364 A/G cg10523679 chr1:76189770 ACADM -0.54 -5.09 -0.3 6.66e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs4654899 1.000 rs6702110 chr1:21515906 A/G cg05370193 chr1:21551575 ECE1 0.36 5.53 0.32 7.6e-8 Superior frontal gyrus grey matter volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21676273 chr3:45635931 LIMD1 -0.42 -6.04 -0.35 5.07e-9 Gambling; CESC cis rs2463822 1.000 rs2513071 chr11:62098387 A/C cg06239285 chr11:62104954 ASRGL1 0.89 8.97 0.48 5.69e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs1348850 0.526 rs4243389 chr2:178379783 G/C cg23306229 chr2:178417860 TTC30B 0.8 7.39 0.41 1.96e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1961456 0.542 rs10095159 chr8:18244684 G/A cg18736775 chr8:18248649 NAT2 -0.47 -5.36 -0.31 1.83e-7 Total cholesterol levels; CESC cis rs6460942 0.915 rs10488158 chr7:12508894 C/T cg02935154 chr7:12443704 VWDE -0.56 -5.77 -0.33 2.22e-8 Coronary artery disease; CESC trans rs4843747 0.671 rs28679286 chr16:88106307 C/T cg26811252 chr16:29126840 RRN3P2 0.67 9.46 0.5 1.77e-18 Menopause (age at onset); CESC cis rs965469 0.779 rs1884563 chr20:3335540 T/C cg17110299 chr20:3385021 C20orf194 0.4 5.26 0.31 3.02e-7 IFN-related cytopenia; CESC cis rs7107174 1.000 rs7104222 chr11:78007169 G/A cg02023728 chr11:77925099 USP35 0.44 6.15 0.35 2.87e-9 Testicular germ cell tumor; CESC cis rs977987 0.835 rs3863445 chr16:75371744 C/G cg03315344 chr16:75512273 CHST6 0.39 5.6 0.33 5.25e-8 Dupuytren's disease; CESC cis rs1348850 0.632 rs13008833 chr2:178514439 G/C cg22681709 chr2:178499509 PDE11A -0.58 -9.09 -0.49 2.35e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg24250549 chr1:154909240 PMVK -0.58 -7.82 -0.43 1.29e-13 Prostate cancer; CESC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg11764359 chr7:65958608 NA -0.73 -9.77 -0.51 1.93e-19 Aortic root size; CESC cis rs13191362 0.507 rs1079020 chr6:163066596 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.59 -7.07 -0.4 1.34e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs35740288 0.539 rs4843101 chr15:86339661 G/T cg20737812 chr15:86336631 KLHL25 -0.48 -5.49 -0.32 9.46e-8 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04347867 chr16:56965804 HERPUD1 0.44 6.06 0.35 4.55e-9 Gut microbiota (bacterial taxa); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03662217 chr21:35747882 FAM165B -0.44 -6.27 -0.36 1.45e-9 Gambling; CESC cis rs933688 1.000 rs2367526 chr5:90740525 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 13.7 0.64 1.17e-32 Smoking behavior; CESC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg05564831 chr3:52568323 NT5DC2 0.48 7.64 0.42 4.06e-13 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07334509 chr8:74361129 STAU2 0.46 6.49 0.37 4.1e-10 Fibrinogen levels; CESC cis rs2574704 0.651 rs2616552 chr3:11666798 G/T cg07643000 chr3:11666825 VGLL4 -0.38 -5.39 -0.31 1.57e-7 Body mass index; CESC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg18180107 chr4:99064573 C4orf37 0.46 5.71 0.33 3.05e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9527 0.590 rs10786738 chr10:104869451 C/T cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs5771242 0.518 rs5771258 chr22:50675648 C/A cg16473166 chr22:50639996 SELO 0.59 6.72 0.38 1.08e-10 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg05644321 chr20:20693493 RALGAPA2 -0.43 -6.82 -0.39 6.01e-11 Vertical cup-disc ratio; CESC cis rs6772849 0.930 rs4857914 chr3:128350684 C/T cg16766828 chr3:128327626 NA -0.31 -5.15 -0.3 5.17e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.28 0.41 3.92e-12 Height; CESC cis rs1538970 0.924 rs6657284 chr1:45879088 T/C cg05343316 chr1:45956843 TESK2 0.85 11.89 0.59 1.99e-26 Platelet count; CESC cis rs77972916 0.505 rs6719754 chr2:43526386 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.58 -5.88 -0.34 1.21e-8 Granulocyte percentage of myeloid white cells; CESC cis rs2481665 0.902 rs1013293 chr1:62570321 G/A cg18591186 chr1:62594603 INADL -0.61 -7.22 -0.41 5.67e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2859741 0.967 rs592520 chr1:37513503 G/C cg09363841 chr1:37513479 NA -0.72 -11.74 -0.58 6.65e-26 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs12200560 0.505 rs211171 chr6:97070579 T/G cg06623918 chr6:96969491 KIAA0776 0.46 5.75 0.33 2.48e-8 Coronary heart disease; CESC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg14159672 chr1:205819179 PM20D1 0.8 11.85 0.59 2.8e-26 Menarche (age at onset); CESC cis rs3857536 0.741 rs2097679 chr6:66937994 T/C cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs4919694 1.000 rs80327774 chr10:104656671 T/C cg04362960 chr10:104952993 NT5C2 0.78 6.53 0.37 3.35e-10 Arsenic metabolism; CESC cis rs9457247 1.000 rs4710147 chr6:167374239 G/A cg07741184 chr6:167504864 NA -0.3 -5.44 -0.32 1.19e-7 Crohn's disease; CESC cis rs6665290 0.904 rs6677602 chr1:227187838 G/T cg10327440 chr1:227177885 CDC42BPA -1.07 -22.43 -0.81 3.45e-63 Myeloid white cell count; CESC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg26338869 chr17:61819248 STRADA 0.7 9.23 0.49 9e-18 Prudent dietary pattern; CESC cis rs113835537 0.597 rs2075792 chr11:66334556 G/A cg24851651 chr11:66362959 CCS 0.5 5.86 0.34 1.39e-8 Airway imaging phenotypes; CESC trans rs9833726 0.789 rs28628150 chr3:86196637 A/C cg10416071 chr15:75628863 COMMD4 0.67 6.38 0.36 7.82e-10 Breast cancer; CESC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg24733560 chr20:60626293 TAF4 0.48 6.83 0.39 5.81e-11 Body mass index; CESC cis rs9314323 0.729 rs7823021 chr8:26224958 G/T cg13160058 chr8:26243215 BNIP3L -0.33 -5.16 -0.3 4.78e-7 Red cell distribution width; CESC cis rs990171 0.506 rs4141631 chr2:102757216 A/G cg22835712 chr2:102737379 NA 0.4 5.7 0.33 3.18e-8 Lymphocyte counts; CESC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg12463550 chr7:65579703 CRCP 0.49 6.21 0.36 2.07e-9 Aortic root size; CESC cis rs17125944 0.505 rs76219229 chr14:53178346 G/A cg00686598 chr14:53173677 PSMC6 1.21 10.58 0.55 4.62e-22 Alzheimer's disease (late onset); CESC cis rs10197940 0.662 rs72860233 chr2:152289767 G/A cg06191203 chr2:152266755 RIF1 -0.45 -5.34 -0.31 2.02e-7 Lung cancer; CESC cis rs7662987 0.938 rs13118409 chr4:99998736 C/G cg13256891 chr4:100009986 ADH5 -0.83 -6.1 -0.35 3.82e-9 Smoking initiation; CESC cis rs113835537 0.597 rs57288351 chr11:66307489 C/T cg24851651 chr11:66362959 CCS 0.52 6.23 0.36 1.84e-9 Airway imaging phenotypes; CESC cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.68 6.29 0.36 1.31e-9 Initial pursuit acceleration; CESC cis rs6793245 0.810 rs1805126 chr3:38592406 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.46 6.18 0.35 2.41e-9 QT interval; CESC cis rs11792861 0.926 rs118011482 chr9:111770626 G/C cg05043794 chr9:111880884 C9orf5 -0.39 -6.4 -0.37 6.9e-10 Menarche (age at onset); CESC cis rs4835473 0.897 rs1450249 chr4:144645578 C/G cg25736465 chr4:144833511 NA 0.38 5.72 0.33 2.94e-8 Immature fraction of reticulocytes; CESC cis rs12220238 1.000 rs10824083 chr10:75911342 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.66 6.68 0.38 1.42e-10 Soluble interleukin-2 receptor subunit alpha; CESC trans rs9398803 0.965 rs2027299 chr6:126685827 G/C cg03991309 chr1:68237761 GNG12 -0.39 -6.04 -0.35 5.23e-9 Male-pattern baldness; CESC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg06456125 chr7:65229604 NA -0.4 -5.58 -0.32 5.92e-8 Aortic root size; CESC cis rs3806843 1.000 rs3822346 chr5:140187322 C/T cg26395211 chr5:140044315 WDR55 -0.42 -5.33 -0.31 2.07e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9522267 0.535 rs9522298 chr13:112234457 C/A cg10483660 chr13:112241077 NA -0.33 -5.79 -0.33 2.04e-8 Hepatitis; CESC cis rs6582630 0.537 rs10785436 chr12:38461040 G/C cg26384229 chr12:38710491 ALG10B 0.67 10.24 0.53 6.11e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs4478858 0.735 rs2271072 chr1:31840426 C/G cg00250761 chr1:31883323 NA -0.26 -5.07 -0.3 7.56e-7 Alcohol dependence; CESC cis rs11122272 0.668 rs1538664 chr1:231555295 C/T cg06096015 chr1:231504339 EGLN1 0.38 5.54 0.32 7.31e-8 Hemoglobin concentration; CESC cis rs2479106 0.892 rs2458490 chr9:126598435 T/C cg16191174 chr9:126692580 DENND1A 0.47 6.47 0.37 4.79e-10 Polycystic ovary syndrome; CESC cis rs6598955 0.724 rs12096059 chr1:26596709 G/A cg00852783 chr1:26633632 UBXN11 0.42 6.23 0.36 1.84e-9 Obesity-related traits; CESC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 11.51 0.58 4.01e-25 Personality dimensions; CESC trans rs6089829 0.962 rs6062780 chr20:61666648 T/C cg23505145 chr19:12996616 KLF1 0.52 6.8 0.39 6.85e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs3015497 0.527 rs2934672 chr14:51152472 T/A cg26011998 chr14:51135199 SAV1 -0.58 -6.45 -0.37 5.31e-10 Mean platelet volume; CESC cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg26597838 chr10:835615 NA 0.76 7.14 0.4 8.95e-12 Eosinophil percentage of granulocytes; CESC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs12931792 0.846 rs9924308 chr16:30154740 C/T cg17640201 chr16:30407289 ZNF48 -0.55 -6.9 -0.39 3.8e-11 Tonsillectomy; CESC cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg05585544 chr11:47624801 NA -0.45 -6.74 -0.38 1e-10 Subjective well-being; CESC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.9 0.39 3.79e-11 Bipolar disorder; CESC cis rs1185460 1.000 rs7938944 chr11:118954066 T/C cg23280166 chr11:118938394 VPS11 0.47 6.24 0.36 1.77e-9 Coronary artery disease; CESC cis rs3815700 0.920 rs10424732 chr19:33096487 C/T cg24916020 chr19:33096688 ANKRD27 0.63 6.11 0.35 3.58e-9 Eosinophilic esophagitis; CESC cis rs12497850 0.931 rs11920534 chr3:48937761 G/T cg07636037 chr3:49044803 WDR6 1.0 18.5 0.75 1.29e-49 Parkinson's disease; CESC cis rs6429082 0.755 rs291371 chr1:235693105 C/G cg26050004 chr1:235667680 B3GALNT2 0.61 8.28 0.45 6.11e-15 Adiposity; CESC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg11764359 chr7:65958608 NA 0.7 10.02 0.52 3.02e-20 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03000844 chr2:242641386 ING5 0.62 7.34 0.41 2.57e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16192717 chr8:101170527 SPAG1 0.54 6.23 0.36 1.84e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17641046 chr3:37034473 MLH1;EPM2AIP1 0.62 7.2 0.4 6.07e-12 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs9688045 chr5:254035 T/C cg20965017 chr5:231967 SDHA -0.47 -5.22 -0.31 3.61e-7 Breast cancer; CESC cis rs4689388 0.750 rs12642481 chr4:6301058 G/A cg00701064 chr4:6280414 WFS1 0.61 9.04 0.49 3.52e-17 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08975529 chr11:70309722 NA 0.53 7.19 0.4 6.43e-12 Fibrinogen levels; CESC cis rs62064224 0.791 rs11653160 chr17:30717222 A/G cg12855166 chr17:30846586 MYO1D 0.41 5.3 0.31 2.46e-7 Schizophrenia; CESC cis rs7264396 0.563 rs11906854 chr20:34383634 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -9.6 -0.51 6.45e-19 Total cholesterol levels; CESC cis rs7818688 0.697 rs2904889 chr8:95940598 T/G cg16049864 chr8:95962084 TP53INP1 0.54 5.38 0.31 1.67e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs992157 0.585 rs62182795 chr2:219100202 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.57 -7.45 -0.42 1.29e-12 Colorectal cancer; CESC cis rs1707322 0.686 rs1250 chr1:46094027 A/G cg05343316 chr1:45956843 TESK2 0.51 6.25 0.36 1.65e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg02487422 chr3:49467188 NICN1 -0.39 -5.52 -0.32 8.11e-8 Menarche (age at onset); CESC trans rs263156 0.567 rs263125 chr6:142939836 A/G cg04848858 chr16:87127923 NA -0.37 -6.15 -0.35 2.9e-9 Ear morphology;Lobe size;Lobe attachment; CESC cis rs4730250 0.707 rs80095766 chr7:106901394 G/T cg02696742 chr7:106810147 HBP1 -0.52 -5.14 -0.3 5.35e-7 Osteoarthritis; CESC cis rs62432291 0.681 rs447637 chr6:159658726 A/G cg14500486 chr6:159655392 FNDC1 -0.63 -6.4 -0.37 7.05e-10 Joint mobility (Beighton score); CESC cis rs731174 0.959 rs12747993 chr1:38190852 T/C cg06917450 chr1:38156652 C1orf109 -0.43 -5.35 -0.31 1.87e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg05598539 chr7:128695331 TNPO3;LOC286016 -0.51 -6.72 -0.38 1.1e-10 Height; CESC cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg05343316 chr1:45956843 TESK2 -0.49 -6.41 -0.37 6.77e-10 High light scatter reticulocyte count; CESC cis rs8028182 0.636 rs4886712 chr15:75812888 C/T cg20655648 chr15:75932815 IMP3 0.48 5.9 0.34 1.08e-8 Sudden cardiac arrest; CESC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg23283495 chr1:209979779 IRF6 0.45 6.88 0.39 4.39e-11 Cleft lip with or without cleft palate; CESC cis rs6088590 0.687 rs6088580 chr20:33285053 G/C cg08999081 chr20:33150536 PIGU 0.64 10.56 0.54 5.39e-22 Coronary artery disease; CESC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg20887711 chr4:1340912 KIAA1530 -0.64 -8.63 -0.47 5.65e-16 Obesity-related traits; CESC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 11.82 0.59 3.57e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg27286337 chr10:134555280 INPP5A 0.65 7.34 0.41 2.56e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2486288 0.656 rs7167146 chr15:45571386 A/G cg21132104 chr15:45694354 SPATA5L1 0.49 5.52 0.32 8.26e-8 Glomerular filtration rate; CESC cis rs9925964 0.804 rs9926533 chr16:31014179 C/T cg02466173 chr16:30829666 NA 0.32 5.14 0.3 5.32e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs472402 0.580 rs4702373 chr5:6633222 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.53 -6.94 -0.39 2.94e-11 Response to amphetamines; CESC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.34 -5.45 -0.32 1.17e-7 Cystic fibrosis severity; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21484680 chr2:27593328 EIF2B4;SNX17 -0.52 -6.34 -0.36 9.9e-10 Ulcerative colitis; CESC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8180040 0.966 rs7649234 chr3:47494380 G/C cg27129171 chr3:47204927 SETD2 0.63 9.66 0.51 4.06e-19 Colorectal cancer; CESC cis rs748404 0.578 rs2278856 chr15:43631356 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.61 0.47 6.76e-16 Lung cancer; CESC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.71 10.42 0.54 1.61e-21 Menarche (age at onset); CESC cis rs11792861 0.926 rs7870597 chr9:111871864 T/C cg13535736 chr9:111863775 C9orf5 -0.5 -6.66 -0.38 1.6e-10 Menarche (age at onset); CESC cis rs8072100 0.846 rs4264433 chr17:45737275 A/T cg08085267 chr17:45401833 C17orf57 0.44 5.8 0.34 1.86e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs4595586 0.505 rs12827136 chr12:39412790 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.36 0.41 2.36e-12 Morning vs. evening chronotype; CESC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.72 -0.33 2.8e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6964587 0.655 rs6465351 chr7:91773213 T/C cg17063962 chr7:91808500 NA 0.44 6.38 0.36 8.04e-10 Breast cancer; CESC cis rs2933343 1.000 rs1683811 chr3:128612113 A/C cg25356066 chr3:128598488 ACAD9 0.6 7.48 0.42 1.09e-12 IgG glycosylation; CESC cis rs78456975 0.527 rs11884165 chr2:1561052 A/G cg12573674 chr2:1569213 NA -0.45 -5.3 -0.31 2.46e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs763014 0.833 rs3743902 chr16:632728 T/C cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC cis rs8112211 1.000 rs7253960 chr19:38814725 C/T cg14299480 chr19:38876666 GGN -0.43 -5.8 -0.34 1.84e-8 Blood protein levels; CESC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg08470875 chr2:26401718 FAM59B -0.69 -7.0 -0.39 2.11e-11 Gut microbiome composition (summer); CESC cis rs858239 0.738 rs13225593 chr7:23260307 A/G cg23682824 chr7:23144976 KLHL7 0.45 5.74 0.33 2.65e-8 Cerebrospinal fluid biomarker levels; CESC cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg19626725 chr5:178986131 RUFY1 -0.34 -5.1 -0.3 6.61e-7 Lung cancer; CESC cis rs62432291 0.681 rs438853 chr6:159630352 A/C cg14500486 chr6:159655392 FNDC1 -0.58 -6.13 -0.35 3.17e-9 Joint mobility (Beighton score); CESC trans rs3942852 0.774 rs2270990 chr11:48184983 G/T cg15704280 chr7:45808275 SEPT13 -0.75 -8.67 -0.47 4.34e-16 Acute lymphoblastic leukemia (childhood); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05673432 chr3:15919505 NA -0.75 -8.26 -0.45 6.92e-15 Gut microbiome composition (summer); CESC cis rs7267979 0.816 rs3746337 chr20:25208272 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.68 10.84 0.55 6.53e-23 Liver enzyme levels (alkaline phosphatase); CESC cis rs698813 0.674 rs6544753 chr2:44501895 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.07 0.3 7.5e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25730573 chr18:60987425 BCL2 0.48 6.12 0.35 3.29e-9 Gut microbiota (bacterial taxa); CESC cis rs472109 1.000 rs93139 chr11:9759608 T/C cg03108697 chr11:9732066 SWAP70 -0.35 -5.33 -0.31 2.15e-7 Coronary artery disease; CESC trans rs208515 0.525 rs10498841 chr6:66663706 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 10.74 0.55 1.42e-22 Exhaled nitric oxide levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05360402 chr5:110848191 STARD4 0.49 6.51 0.37 3.67e-10 Gut microbiota (bacterial taxa); CESC cis rs17209837 1.000 rs67721532 chr7:87084403 A/G cg00919237 chr7:87102261 ABCB4 -0.55 -5.61 -0.33 5.09e-8 Gallbladder cancer; CESC cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg21918786 chr6:109611834 NA -0.39 -5.98 -0.34 7.14e-9 Reticulocyte fraction of red cells; CESC cis rs10208940 0.920 rs28361349 chr2:68785579 G/A cg12452813 chr2:68675892 NA 0.52 5.25 0.31 3.12e-7 Urate levels in lean individuals; CESC trans rs877282 0.853 rs12763400 chr10:763617 C/T cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs9457247 0.740 rs13195812 chr6:167443902 C/T cg07741184 chr6:167504864 NA 0.37 6.54 0.37 3.16e-10 Crohn's disease; CESC trans rs61931739 0.500 rs34107854 chr12:34482333 C/A cg13010199 chr12:38710504 ALG10B 0.5 6.5 0.37 3.92e-10 Morning vs. evening chronotype; CESC cis rs3806843 0.676 rs753280 chr5:140024042 C/T cg16577123 chr5:140027231 NDUFA2;IK 0.44 5.73 0.33 2.7e-8 Depressive symptoms (multi-trait analysis); CESC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg17971929 chr21:40555470 PSMG1 -0.83 -11.67 -0.58 1.16e-25 Cognitive function; CESC cis rs8017423 0.565 rs4904681 chr14:90835566 A/T cg14092571 chr14:90743983 NA 0.44 6.46 0.37 4.94e-10 Mortality in heart failure; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10683658 chr6:97345925 NDUFAF4 0.46 6.0 0.35 6.4e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs743757 1.000 rs2236968 chr3:50465975 A/G cg10928302 chr3:50126174 RBM5 0.53 5.08 0.3 7.24e-7 Diastolic blood pressure; CESC cis rs7617480 0.585 rs7373072 chr3:48960017 T/A cg07636037 chr3:49044803 WDR6 0.88 12.98 0.62 3.71e-30 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs4450798 0.593 rs4552329 chr3:13785609 T/C cg05589046 chr3:13742034 LOC285375 0.34 5.21 0.3 3.79e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1107366 0.750 rs9825571 chr3:125900161 A/G cg08481491 chr3:125900108 ALDH1L1 -0.36 -5.29 -0.31 2.62e-7 Metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16116244 chr1:16939841 NBPF1 -0.47 -6.32 -0.36 1.11e-9 Fibrinogen levels; CESC cis rs60843830 1.000 rs58461606 chr2:267367 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.8 10.61 0.55 3.67e-22 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4919044 0.740 rs73319304 chr10:94777045 A/G cg16508068 chr10:94451736 HHEX -0.5 -5.49 -0.32 9.61e-8 Coronary artery disease; CESC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg12310025 chr6:25882481 NA -0.49 -6.9 -0.39 3.76e-11 Intelligence (multi-trait analysis); CESC cis rs12893668 0.703 rs729438 chr14:104092789 A/G cg24130564 chr14:104152367 KLC1 0.43 5.43 0.32 1.3e-7 Reticulocyte count; CESC trans rs60843830 1.000 rs3791220 chr2:227066 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 7.97 0.44 4.88e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9858542 0.953 rs11719996 chr3:49525958 T/C cg07274523 chr3:49395745 GPX1 0.66 8.05 0.44 2.78e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg07870213 chr5:140052090 DND1 -0.58 -6.45 -0.37 5.28e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7927592 0.913 rs4316515 chr11:68308840 A/T cg20283391 chr11:68216788 NA 0.59 7.12 0.4 1.01e-11 Total body bone mineral density; CESC cis rs7267005 0.661 rs2425085 chr20:34302402 T/C cg17201900 chr20:34330562 RBM39 0.98 5.28 0.31 2.64e-7 Response to paliperidone in schizophrenia (Multivariate); CESC cis rs1568889 1.000 rs12800354 chr11:28047723 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.69 8.08 0.44 2.26e-14 Bipolar disorder; CESC cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg02187348 chr16:89574699 SPG7 -0.52 -6.48 -0.37 4.47e-10 Multiple myeloma (IgH translocation); CESC cis rs12325245 0.536 rs12925676 chr16:58625326 C/T cg02549819 chr16:58548995 SETD6 0.95 6.11 0.35 3.54e-9 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02247898 chr14:55033728 SAMD4A -0.57 -6.27 -0.36 1.44e-9 Gut microbiome composition (summer); CESC cis rs2250402 0.510 rs7535 chr15:40328575 G/C cg10636054 chr15:40330586 SRP14 0.92 7.03 0.4 1.77e-11 Corneal curvature; CESC cis rs7772486 0.743 rs111332144 chr6:146056681 C/T cg23711669 chr6:146136114 FBXO30 -0.68 -9.94 -0.52 5.56e-20 Lobe attachment (rater-scored or self-reported); CESC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg09060608 chr5:178986726 RUFY1 0.57 8.88 0.48 1.06e-16 Lung cancer; CESC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.54 -0.32 7.16e-8 Lung cancer; CESC cis rs7474896 0.583 rs10827818 chr10:38000856 T/C cg25427524 chr10:38739819 LOC399744 -0.48 -5.6 -0.33 5.35e-8 Obesity (extreme); CESC cis rs858239 0.539 rs4559148 chr7:23185967 G/A cg23682824 chr7:23144976 KLHL7 0.46 5.85 0.34 1.45e-8 Cerebrospinal fluid biomarker levels; CESC cis rs11153306 0.677 rs3777921 chr6:111924410 C/T cg22127309 chr6:111907043 TRAF3IP2 0.39 5.76 0.33 2.38e-8 Tonsillectomy; CESC trans rs208515 0.556 rs12201658 chr6:66678457 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.9 0.56 4.24e-23 Exhaled nitric oxide levels; CESC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg23283495 chr1:209979779 IRF6 0.55 7.83 0.43 1.15e-13 Cleft lip with or without cleft palate; CESC cis rs1538970 0.924 rs1494812 chr1:45876999 C/T cg05343316 chr1:45956843 TESK2 0.85 11.89 0.59 1.99e-26 Platelet count; CESC cis rs17023223 0.537 rs12081327 chr1:119686358 A/G cg05756136 chr1:119680316 WARS2 -0.46 -5.58 -0.32 6.01e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs55871839 0.708 rs12114218 chr8:59817454 T/C cg07426533 chr8:59803705 TOX -0.5 -7.25 -0.41 4.68e-12 Pneumonia; CESC cis rs4555082 0.957 rs3825762 chr14:105752404 T/C cg13114125 chr14:105738426 BRF1 -0.71 -9.01 -0.48 4.09e-17 Mean platelet volume;Platelet distribution width; CESC cis rs3026101 0.671 rs1143206 chr17:5284698 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.89 0.34 1.18e-8 Body mass index; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03961984 chr1:55229700 PARS2 -0.42 -6.08 -0.35 4.17e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg03396347 chr1:1875803 NA -0.43 -6.63 -0.38 1.91e-10 Body mass index; CESC cis rs2361718 0.500 rs12451697 chr17:78100690 T/A cg21238619 chr17:78079768 GAA -0.4 -6.02 -0.35 5.91e-9 Yeast infection; CESC cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg14298792 chr15:30685198 CHRFAM7A 0.51 5.25 0.31 3.11e-7 Huntington's disease progression; CESC cis rs9814567 1.000 rs6766818 chr3:134226159 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.05 -0.35 4.82e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2635047 0.967 rs12960378 chr18:44614090 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.46 6.23 0.36 1.85e-9 Educational attainment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27030336 chr7:43798661 BLVRA 0.55 6.04 0.35 5.06e-9 Gut microbiome composition (summer); CESC cis rs28489187 0.706 rs233108 chr1:85781720 C/T cg16011679 chr1:85725395 C1orf52 0.49 5.86 0.34 1.39e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg27170947 chr2:26402098 FAM59B -0.6 -7.25 -0.41 4.7e-12 Gut microbiome composition (summer); CESC cis rs7605827 0.930 rs4668450 chr2:15675011 C/T cg19274914 chr2:15703543 NA 0.38 6.8 0.39 7.12e-11 Educational attainment (years of education); CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg18404041 chr3:52824283 ITIH1 0.35 6.27 0.36 1.42e-9 Electroencephalogram traits; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03944810 chr2:208031995 KLF7 0.39 6.08 0.35 4.18e-9 Systemic lupus erythematosus; CESC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.22e-8 Lung cancer; CESC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg14558114 chr2:88469736 THNSL2 -0.57 -5.25 -0.31 3.05e-7 Plasma clusterin levels; CESC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg22535103 chr8:58192502 C8orf71 -0.9 -8.95 -0.48 6.29e-17 Developmental language disorder (linguistic errors); CESC cis rs9287719 0.901 rs55861579 chr2:10763340 T/A cg00105475 chr2:10696890 NA 0.37 5.27 0.31 2.81e-7 Prostate cancer; CESC cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg26531700 chr6:26746687 NA 0.44 6.91 0.39 3.7e-11 Intelligence (multi-trait analysis); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg07630564 chr3:128445061 RAB7A -0.44 -6.41 -0.37 6.51e-10 Breast cancer; CESC cis rs12681288 0.644 rs2123058 chr8:1000304 A/G cg15309053 chr8:964076 NA 0.39 6.61 0.38 2.07e-10 Schizophrenia; CESC cis rs7520050 0.807 rs72688483 chr1:46149209 A/G cg03146154 chr1:46216737 IPP 0.52 6.86 0.39 4.96e-11 Red blood cell count;Reticulocyte count; CESC cis rs7512552 0.768 rs7517441 chr1:150283643 A/T cg15654264 chr1:150340011 RPRD2 -0.42 -5.42 -0.32 1.32e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs7582720 1.000 rs72936323 chr2:204050474 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.83 7.07 0.4 1.41e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.11e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7116495 0.737 rs7101553 chr11:71753903 C/T cg18441811 chr11:71824068 C11orf51 -0.85 -5.38 -0.31 1.65e-7 Severe influenza A (H1N1) infection; CESC cis rs7178909 0.800 rs3825866 chr15:90437638 A/T cg19708238 chr15:90437601 AP3S2 0.43 6.19 0.36 2.25e-9 Common traits (Other); CESC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg05564831 chr3:52568323 NT5DC2 0.46 7.33 0.41 2.88e-12 Bipolar disorder; CESC cis rs10465746 0.967 rs12120160 chr1:84342835 T/G cg10977910 chr1:84465055 TTLL7 0.48 6.52 0.37 3.64e-10 Obesity-related traits; CESC cis rs9926296 0.706 rs2159115 chr16:89831819 A/G cg04287289 chr16:89883240 FANCA 0.58 7.56 0.42 6.42e-13 Vitiligo; CESC cis rs4780401 0.782 rs933573 chr16:11793395 A/G cg01061890 chr16:11836724 TXNDC11 0.41 5.62 0.33 4.83e-8 Rheumatoid arthritis; CESC cis rs10492096 1.000 rs12422771 chr12:6580273 G/T cg13857086 chr12:6580257 VAMP1 0.69 6.95 0.39 2.88e-11 Hip geometry; CESC cis rs28647808 1.000 rs28460103 chr9:136278763 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.89 5.69 0.33 3.41e-8 Blood protein levels; CESC cis rs6570726 0.811 rs375873 chr6:145812371 G/T cg05347473 chr6:146136440 FBXO30 0.48 6.46 0.37 4.93e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1448094 0.717 rs55811543 chr12:86290936 C/T cg02569458 chr12:86230093 RASSF9 0.38 5.41 0.32 1.4e-7 Major depressive disorder; CESC cis rs10979 1.000 rs3748072 chr6:143889757 C/T cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs10861342 1.000 rs11112397 chr12:105568381 T/C cg23923672 chr12:105501055 KIAA1033 0.62 5.38 0.31 1.66e-7 IgG glycosylation; CESC cis rs72781680 0.898 rs12619592 chr2:23971415 C/A cg08917208 chr2:24149416 ATAD2B 0.96 8.67 0.47 4.28e-16 Lymphocyte counts; CESC cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg22307029 chr19:49891270 CCDC155 0.55 6.0 0.35 6.6e-9 Multiple sclerosis; CESC cis rs2839186 0.565 rs2839183 chr21:47687144 G/A cg12379764 chr21:47803548 PCNT 0.44 5.48 0.32 9.66e-8 Testicular germ cell tumor; CESC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg00149659 chr3:10157352 C3orf10 0.7 8.38 0.46 3.2e-15 Alzheimer's disease; CESC cis rs4237845 0.537 rs12426201 chr12:58259752 C/T cg00677455 chr12:58241039 CTDSP2 0.77 10.17 0.53 1.03e-20 Intelligence (multi-trait analysis); CESC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.26 0.36 1.52e-9 Bipolar disorder; CESC cis rs7223966 1.000 rs8080211 chr17:61729882 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.17 0.35 2.52e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1062177 1.000 rs973529 chr5:151188158 T/C cg00977110 chr5:151150581 G3BP1 0.63 6.88 0.39 4.37e-11 Preschool internalizing problems; CESC cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg06713675 chr4:122721982 EXOSC9 -0.51 -6.96 -0.39 2.71e-11 Type 2 diabetes; CESC trans rs79976124 0.842 rs7760550 chr6:66628788 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.69 7.95 0.44 5.31e-14 Type 2 diabetes; CESC cis rs2243480 1.000 rs1499613 chr7:65730860 G/A cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs9910055 0.659 rs8079310 chr17:42270291 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.65 8.59 0.47 7.46e-16 Total body bone mineral density; CESC cis rs6987853 0.761 rs2974321 chr8:42424727 A/G cg09913449 chr8:42400586 C8orf40 0.46 7.83 0.43 1.17e-13 Mean corpuscular hemoglobin concentration; CESC trans rs1814175 0.817 rs10839465 chr11:49981554 C/A cg03929089 chr4:120376271 NA -0.93 -16.32 -0.71 6.51e-42 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08274380 chr1:109419600 GPSM2 0.61 6.58 0.37 2.53e-10 Gut microbiome composition (summer); CESC cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC cis rs12618769 0.597 rs12619665 chr2:99126551 A/T cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.68e-7 Bipolar disorder; CESC cis rs1348850 0.519 rs4144275 chr2:178523368 C/T cg23306229 chr2:178417860 TTC30B 0.46 5.38 0.31 1.67e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2243480 1.000 rs2961102 chr7:65424658 A/G cg13147721 chr7:65941812 NA -0.9 -8.62 -0.47 6.11e-16 Diabetic kidney disease; CESC cis rs1568889 1.000 rs9783375 chr11:28033667 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.69 8.16 0.45 1.38e-14 Bipolar disorder; CESC cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg14558114 chr2:88469736 THNSL2 -0.46 -6.5 -0.37 4.08e-10 Response to metformin (IC50); CESC trans rs7937682 0.889 rs493810 chr11:111491888 G/T cg18187862 chr3:45730750 SACM1L 0.48 6.01 0.35 6.26e-9 Primary sclerosing cholangitis; CESC cis rs6693567 0.565 rs1776276 chr1:150293078 A/C cg09579323 chr1:150459698 TARS2 0.47 6.13 0.35 3.18e-9 Migraine; CESC cis rs6120849 0.663 rs6088662 chr20:33547633 A/C cg24642439 chr20:33292090 TP53INP2 0.67 6.86 0.39 4.87e-11 Protein C levels; CESC cis rs12142240 0.698 rs67142569 chr1:46828460 C/T cg00530320 chr1:46809349 NSUN4 0.6 8.01 0.44 3.75e-14 Menopause (age at onset); CESC cis rs7809950 1.000 rs10267907 chr7:107184466 C/T cg23024343 chr7:107201750 COG5 -0.43 -5.9 -0.34 1.13e-8 Coronary artery disease; CESC cis rs9486719 1.000 rs11153067 chr6:97039421 A/T cg06623918 chr6:96969491 KIAA0776 0.78 7.93 0.44 6.02e-14 Migraine;Coronary artery disease; CESC trans rs9467711 0.790 rs66488313 chr6:26631568 G/T cg01620082 chr3:125678407 NA -0.85 -6.44 -0.37 5.75e-10 Autism spectrum disorder or schizophrenia; CESC trans rs7786808 0.712 rs12671981 chr7:158202971 G/A cg03441993 chr4:55093323 NA 0.4 6.06 0.35 4.71e-9 Obesity-related traits; CESC cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 6.08 0.35 4.17e-9 Colorectal cancer; CESC cis rs9309473 1.000 rs3738848 chr2:73761881 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.2 -0.36 2.12e-9 Metabolite levels; CESC cis rs10479542 0.929 rs10078796 chr5:178978883 T/A cg22764044 chr5:178986830 RUFY1 0.46 6.82 0.39 6.22e-11 Lung cancer; CESC cis rs9308433 0.643 rs955920 chr1:214464309 G/A cg06198575 chr1:214491504 SMYD2 0.44 5.11 0.3 6.14e-7 IgG glycosylation; CESC cis rs9430161 0.611 rs72644043 chr1:11033051 T/A cg02454025 chr1:11042201 C1orf127 0.99 16.1 0.7 3.84e-41 Ewing sarcoma; CESC cis rs3747547 0.581 rs943932 chr9:38132048 C/T cg13774184 chr9:37916125 SHB -0.65 -5.3 -0.31 2.4e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.06 12.34 0.6 5.85e-28 Gut microbiome composition (summer); CESC cis rs36051895 0.659 rs7856912 chr9:5184449 G/A cg02405213 chr9:5042618 JAK2 -0.53 -6.36 -0.36 9.03e-10 Pediatric autoimmune diseases; CESC cis rs2447097 1.000 rs2447097 chr17:2278064 A/C cg27406664 chr17:2294951 MNT 0.34 5.62 0.33 4.8e-8 Autism spectrum disorder; CESC cis rs17376456 0.877 rs10476598 chr5:93367281 C/T cg21475434 chr5:93447410 FAM172A -0.76 -6.88 -0.39 4.34e-11 Diabetic retinopathy; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07185584 chr20:19997881 NAA20 0.55 7.36 0.41 2.37e-12 Systemic lupus erythematosus; CESC cis rs9287719 0.967 rs6432114 chr2:10744930 C/T cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.37e-8 Prostate cancer; CESC cis rs76793172 0.920 rs113577760 chr19:46365177 T/C cg12641515 chr19:46296257 DMWD -0.8 -5.04 -0.3 8.66e-7 Eosinophil counts; CESC cis rs34779708 0.868 rs2384352 chr10:35492832 A/G cg04310649 chr10:35416472 CREM -0.53 -6.3 -0.36 1.27e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9905704 0.718 rs4793953 chr17:56613104 C/G cg12560992 chr17:57184187 TRIM37 -0.64 -6.09 -0.35 4.06e-9 Testicular germ cell tumor; CESC cis rs2070488 0.965 rs1065800 chr3:38566480 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.91 -17.03 -0.72 1.95e-44 Electrocardiographic conduction measures; CESC cis rs703842 0.616 rs4760171 chr12:58225904 A/G cg00677455 chr12:58241039 CTDSP2 0.73 10.39 0.54 2.01e-21 Multiple sclerosis; CESC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg23161317 chr6:28129485 ZNF389 0.49 6.19 0.36 2.28e-9 Parkinson's disease; CESC cis rs5758511 0.514 rs5751211 chr22:42486056 G/A cg00645731 chr22:42541494 CYP2D7P1 0.63 9.78 0.52 1.69e-19 Birth weight; CESC cis rs12477438 0.520 rs13012481 chr2:99754290 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.16 0.68 8.27e-38 Chronic sinus infection; CESC cis rs66573146 1.000 rs66519732 chr4:6990569 C/G cg00086871 chr4:6988644 TBC1D14 1.12 6.35 0.36 9.34e-10 Granulocyte percentage of myeloid white cells; CESC cis rs2637266 0.935 rs2583048 chr10:78404507 C/G cg18941641 chr10:78392320 NA 0.44 8.56 0.47 9.45e-16 Pulmonary function; CESC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg03388025 chr16:89894329 SPIRE2 0.41 7.92 0.44 6.63e-14 Vitiligo; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02252918 chr12:124458442 ZNF664;CCDC92 0.54 7.06 0.4 1.43e-11 Gut microbiota (bacterial taxa); CESC cis rs12824058 0.799 rs4759656 chr12:130815804 G/A cg23887609 chr12:130822674 PIWIL1 0.45 5.86 0.34 1.38e-8 Menopause (age at onset); CESC cis rs12545109 0.800 rs2582401 chr8:57401656 A/G cg09654669 chr8:57350985 NA -0.56 -6.59 -0.38 2.31e-10 Obesity-related traits; CESC cis rs4595586 0.525 rs11609150 chr12:39408622 A/C cg13010199 chr12:38710504 ALG10B 0.45 5.57 0.32 6.23e-8 Morning vs. evening chronotype; CESC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg07256732 chr16:621771 PIGQ -0.34 -5.88 -0.34 1.22e-8 Height; CESC cis rs253664 0.897 rs1199336 chr3:138088221 T/A cg17918682 chr3:137893718 DBR1 -0.48 -5.16 -0.3 4.9e-7 Body mass index; CESC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg25072359 chr17:41440525 NA 0.48 7.12 0.4 1.04e-11 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16025584 chr9:139887217 C9orf142 -0.43 -6.29 -0.36 1.3e-9 Gambling; CESC cis rs7216064 1.000 rs55896768 chr17:65913358 T/C cg07042672 chr17:66097459 LOC651250 -0.62 -7.72 -0.43 2.34e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2228479 0.618 rs72477006 chr16:89950299 G/C cg04013166 chr16:89971882 TCF25 0.73 6.49 0.37 4.21e-10 Skin colour saturation; CESC cis rs10789491 1.000 rs2218191 chr1:47130628 C/T cg15501359 chr1:47185051 KIAA0494 0.54 6.45 0.37 5.34e-10 Response to hepatitis C treatment; CESC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.52 5.85 0.34 1.44e-8 Lung function (FEV1/FVC); CESC cis rs7917772 0.503 rs11191328 chr10:104305185 C/T cg22532475 chr10:104410764 TRIM8 -0.33 -5.65 -0.33 4.19e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg22800045 chr5:56110881 MAP3K1 -0.6 -7.63 -0.42 4.11e-13 Initial pursuit acceleration; CESC cis rs2739330 0.892 rs5751776 chr22:24266954 A/C cg16132339 chr22:24313637 DDTL;DDT 0.36 5.42 0.32 1.32e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.51 7.31 0.41 3.2e-12 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16638425 chr16:2946805 FLYWCH2 -0.54 -6.45 -0.37 5.27e-10 Gut microbiome composition (summer); CESC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg06481639 chr22:41940642 POLR3H -0.55 -5.68 -0.33 3.46e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg23758822 chr17:41437982 NA 1.02 12.82 0.62 1.29e-29 Menopause (age at onset); CESC cis rs34330 0.562 rs10845615 chr12:12863470 C/T cg09462578 chr12:12878428 APOLD1 -0.75 -8.47 -0.46 1.7e-15 Systemic lupus erythematosus; CESC cis rs1003719 0.715 rs2252893 chr21:38507572 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.47 -0.46 1.69e-15 Eye color traits; CESC cis rs763121 0.819 rs5750629 chr22:38985065 T/C cg21395723 chr22:39101663 GTPBP1 0.51 6.82 0.39 6.01e-11 Menopause (age at onset); CESC cis rs965469 0.895 rs6051840 chr20:3391483 C/T cg25506879 chr20:3388711 C20orf194 0.58 6.44 0.37 5.51e-10 IFN-related cytopenia; CESC trans rs4756846 1.000 rs4757400 chr11:16469929 T/C cg05579622 chr5:10618622 ANKRD33B 0.73 6.85 0.39 5.11e-11 Obesity and osteoporosis; CESC cis rs35306767 0.855 rs12781100 chr10:838636 C/T cg20503657 chr10:835505 NA 1.08 10.23 0.53 6.64e-21 Eosinophil percentage of granulocytes; CESC cis rs4849845 0.573 rs33971369 chr2:121024987 A/G cg24070213 chr2:121070622 NA 0.45 6.67 0.38 1.53e-10 Mean platelet volume; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15731816 chr14:75230414 YLPM1 0.5 6.98 0.39 2.39e-11 Systemic lupus erythematosus; CESC cis rs9611565 0.506 rs4822020 chr22:41700203 C/T cg06634786 chr22:41940651 POLR3H -0.51 -5.53 -0.32 7.85e-8 Vitiligo; CESC cis rs4148883 0.645 rs2851287 chr4:100014548 G/A cg13256891 chr4:100009986 ADH5 0.56 7.17 0.4 7.63e-12 Alcohol dependence; CESC cis rs72781680 0.950 rs72796402 chr2:24180104 A/G cg08917208 chr2:24149416 ATAD2B 1.12 10.07 0.53 2.16e-20 Lymphocyte counts; CESC cis rs4889855 0.614 rs9898443 chr17:78469357 C/T cg10586883 chr17:79312681 NA 0.38 5.07 0.3 7.5e-7 Fractional excretion of uric acid; CESC cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -8.24 -0.45 8.12e-15 Developmental language disorder (linguistic errors); CESC cis rs2742234 0.541 rs871763 chr10:43734188 C/T cg15436174 chr10:43711423 RASGEF1A 0.47 5.52 0.32 7.96e-8 Hirschsprung disease; CESC cis rs748404 0.660 rs2467742 chr15:43750237 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.35 0.46 3.89e-15 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14361189 chr14:19360467 NA -0.58 -7.51 -0.42 9.07e-13 Gut microbiome composition (summer); CESC cis rs2236918 0.901 rs1776135 chr1:242025530 A/G cg17736920 chr1:242011382 EXO1 0.72 9.62 0.51 5.63e-19 Menopause (age at onset); CESC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg18016565 chr1:150552671 MCL1 0.34 5.39 0.31 1.53e-7 Urate levels; CESC cis rs6540556 0.954 rs2076150 chr1:209933540 A/G cg23920097 chr1:209922102 NA -0.37 -5.54 -0.32 7.2e-8 Red blood cell count; CESC cis rs12142240 0.698 rs72679807 chr1:46846490 G/A cg00530320 chr1:46809349 NSUN4 0.6 8.3 0.45 5.19e-15 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04944291 chr3:195270345 PPP1R2 0.46 6.04 0.35 5.15e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs477895 1.000 rs66968227 chr11:64070930 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.76 6.37 0.36 8.41e-10 Mean platelet volume; CESC cis rs7085104 0.572 rs284860 chr10:104572963 T/C cg23093090 chr10:104574429 C10orf26 0.34 5.41 0.32 1.39e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs11690935 0.550 rs11676438 chr2:172826668 G/A cg13550731 chr2:172543902 DYNC1I2 0.46 6.29 0.36 1.31e-9 Schizophrenia; CESC trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.56 7.94 0.44 5.74e-14 Intelligence (multi-trait analysis); CESC cis rs1642645 0.831 rs7535305 chr1:42489602 C/A cg16685388 chr1:42384056 HIVEP3 0.37 5.49 0.32 9.65e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs2635047 0.638 rs2668784 chr18:44711391 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.59 0.32 5.7e-8 Educational attainment; CESC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg23172400 chr8:95962367 TP53INP1 -0.4 -8.11 -0.45 1.88e-14 Type 2 diabetes; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg11287903 chr10:115613834 DCLRE1A;NHLRC2 0.46 6.01 0.35 6.06e-9 Weight; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg18765753 chr7:1198926 ZFAND2A -0.54 -8.16 -0.45 1.32e-14 Longevity;Endometriosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15889649 chr15:79055693 ADAMTS7 0.48 6.97 0.39 2.59e-11 Fibrinogen levels; CESC cis rs9788333 0.762 rs4441120 chr13:21886863 T/A cg23743428 chr13:21893420 NA -0.33 -5.38 -0.31 1.62e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg16145915 chr7:1198662 ZFAND2A -0.47 -5.24 -0.31 3.22e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2066819 1.000 rs1274493 chr12:56682371 C/T cg26734620 chr12:56694298 CS -0.93 -9.55 -0.51 9.4e-19 Psoriasis vulgaris; CESC cis rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19803976 chr18:11850907 CHMP1B;GNAL -0.47 -6.02 -0.35 5.67e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4835473 0.897 rs1391189 chr4:144612104 T/C cg25736465 chr4:144833511 NA -0.34 -5.05 -0.3 8.41e-7 Immature fraction of reticulocytes; CESC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg12516959 chr21:47718080 NA -0.49 -6.7 -0.38 1.26e-10 Testicular germ cell tumor; CESC cis rs2991971 0.810 rs2036021 chr1:45901370 G/A cg05343316 chr1:45956843 TESK2 -0.57 -8.16 -0.45 1.32e-14 High light scatter reticulocyte count; CESC cis rs3096299 0.967 rs16965692 chr16:89471482 C/T cg08822215 chr16:89438651 ANKRD11 -0.4 -6.25 -0.36 1.61e-9 Multiple myeloma (IgH translocation); CESC cis rs10465746 0.570 rs1886769 chr1:84471134 C/A cg10977910 chr1:84465055 TTLL7 0.44 5.63 0.33 4.57e-8 Obesity-related traits; CESC cis rs12497850 0.931 rs7623023 chr3:48914238 G/A cg07636037 chr3:49044803 WDR6 0.99 18.24 0.75 1.02e-48 Parkinson's disease; CESC cis rs9388451 0.839 rs3799711 chr6:126075313 C/T cg05901451 chr6:126070800 HEY2 0.66 9.34 0.5 4.14e-18 Brugada syndrome; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07869135 chr8:123794843 ZHX2 -0.44 -6.25 -0.36 1.64e-9 Gambling; CESC cis rs75477785 1.000 rs77542756 chr1:209989281 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs6747952 0.899 rs2880132 chr2:239082976 G/A cg17459225 chr2:239074497 NA 0.32 5.1 0.3 6.53e-7 Mean corpuscular hemoglobin concentration; CESC cis rs9905704 0.633 rs2680713 chr17:56523900 G/T cg12560992 chr17:57184187 TRIM37 0.6 5.62 0.33 4.85e-8 Testicular germ cell tumor; CESC cis rs258892 0.895 rs34206264 chr5:72059806 C/G cg21869765 chr5:72125136 TNPO1 -0.43 -5.35 -0.31 1.93e-7 Small cell lung carcinoma; CESC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg14820908 chr5:178986412 RUFY1 0.51 7.97 0.44 4.64e-14 Lung cancer; CESC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.49 0.37 4.2e-10 Bipolar disorder; CESC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg11301795 chr4:187892539 NA -0.75 -12.33 -0.6 6.74e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg17949981 chr6:28129498 ZNF389 0.45 5.71 0.33 3.07e-8 Depression; CESC cis rs12478296 1.000 rs66612947 chr2:243035962 A/T cg06360820 chr2:242988706 NA -0.68 -7.6 -0.42 5.02e-13 Obesity-related traits; CESC cis rs12477438 0.520 rs12621007 chr2:99791946 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.26 0.71 1.06e-41 Chronic sinus infection; CESC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.93 10.65 0.55 2.74e-22 Platelet count; CESC cis rs2439831 1.000 rs689647 chr15:43762196 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.58 0.54 4.72e-22 Lung cancer in ever smokers; CESC cis rs5753037 0.653 rs131285 chr22:30157940 T/C cg01021169 chr22:30184971 ASCC2 -0.44 -6.11 -0.35 3.52e-9 Type 1 diabetes; CESC cis rs506597 0.920 rs534043 chr7:100312724 A/G cg10426581 chr7:100472382 SRRT -0.62 -5.07 -0.3 7.32e-7 Pursuit maintenance gain in psychotic disorders; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03442064 chr6:41515050 FOXP4 0.44 6.02 0.35 5.71e-9 Systemic lupus erythematosus; CESC cis rs5744897 0.581 rs35235926 chr12:133304126 G/A cg17341477 chr12:133246679 POLE 0.57 5.25 0.31 3.16e-7 Urate levels in overweight individuals; CESC cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg05340658 chr4:99064831 C4orf37 0.76 11.14 0.56 6.8e-24 Colonoscopy-negative controls vs population controls; CESC cis rs12220238 1.000 rs11000941 chr10:76018301 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.63 5.72 0.33 2.87e-8 Soluble interleukin-2 receptor subunit alpha; CESC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg15664640 chr17:80829946 TBCD 0.4 5.7 0.33 3.11e-8 Breast cancer; CESC cis rs12142240 0.698 rs17361950 chr1:46864150 C/T cg10495392 chr1:46806563 NSUN4 0.55 5.93 0.34 9.24e-9 Menopause (age at onset); CESC cis rs9399135 0.967 rs2327578 chr6:135329969 C/T cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs17376456 0.825 rs10056879 chr5:93282218 C/A cg25358565 chr5:93447407 FAM172A 1.14 9.72 0.51 2.6e-19 Diabetic retinopathy; CESC cis rs2637266 0.905 rs1907313 chr10:78338072 A/G cg18941641 chr10:78392320 NA 0.39 7.21 0.41 5.78e-12 Pulmonary function; CESC trans rs11098499 0.865 rs28634456 chr4:120375778 A/G cg25214090 chr10:38739885 LOC399744 0.69 9.59 0.51 6.76e-19 Corneal astigmatism; CESC cis rs2070488 0.965 rs6599209 chr3:38558197 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.9 -16.53 -0.71 1.16e-42 Electrocardiographic conduction measures; CESC trans rs6445797 0.632 rs2029464 chr3:56661320 T/G cg15444621 chr13:113611794 NA 0.34 6.1 0.35 3.64e-9 Gastritis; CESC cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg22875332 chr1:76189707 ACADM 0.7 9.65 0.51 4.56e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg06028808 chr11:68637592 NA 0.41 5.06 0.3 7.97e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2243480 1.000 rs465359 chr7:65558164 C/T cg12463550 chr7:65579703 CRCP 0.74 5.71 0.33 3.02e-8 Diabetic kidney disease; CESC cis rs7845219 0.544 rs10956932 chr8:95948202 C/T cg23172400 chr8:95962367 TP53INP1 0.33 6.11 0.35 3.52e-9 Type 2 diabetes; CESC cis rs2072732 0.861 rs12044848 chr1:2960790 C/T cg03976712 chr1:2946727 NA 0.35 5.63 0.33 4.52e-8 Plateletcrit; CESC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg19717773 chr7:2847554 GNA12 -0.55 -7.78 -0.43 1.59e-13 Height; CESC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg23978390 chr7:1156363 C7orf50 0.46 6.24 0.36 1.72e-9 Longevity;Endometriosis; CESC cis rs8067545 0.611 rs7219615 chr17:20132558 T/A cg13482628 chr17:19912719 NA -0.42 -5.64 -0.33 4.46e-8 Schizophrenia; CESC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg09699651 chr6:150184138 LRP11 0.4 5.14 0.3 5.29e-7 Lung cancer; CESC cis rs6580649 0.598 rs1793913 chr12:48387025 T/A cg05342945 chr12:48394962 COL2A1 -0.49 -5.97 -0.34 7.7e-9 Lung cancer; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg09242721 chr3:3168535 TRNT1 0.47 6.25 0.36 1.67e-9 Breast cancer;Type 2 diabetes; CESC cis rs2694528 0.686 rs7729652 chr5:59872414 A/G cg11474532 chr5:59995715 DEPDC1B 0.9 6.32 0.36 1.1e-9 Parkinson's disease; CESC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg24562669 chr7:97807699 LMTK2 -0.44 -6.4 -0.37 7.11e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg03609598 chr5:56110824 MAP3K1 -0.51 -5.41 -0.32 1.38e-7 Initial pursuit acceleration; CESC cis rs4077515 0.934 rs10781507 chr9:139272058 A/G cg14169450 chr9:139327907 INPP5E 0.36 5.24 0.31 3.27e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs11785400 0.793 rs4736364 chr8:143742113 C/T cg24634471 chr8:143751801 JRK 0.46 5.94 0.34 8.96e-9 Schizophrenia; CESC cis rs2932538 0.922 rs3790611 chr1:113067792 A/G cg22162597 chr1:113214053 CAPZA1 0.51 6.48 0.37 4.54e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg10057126 chr4:77819792 ANKRD56 0.54 7.56 0.42 6.7e-13 Emphysema distribution in smoking; CESC cis rs6963495 0.818 rs1355614 chr7:105179176 A/G cg02135003 chr7:105160482 PUS7 -0.45 -6.26 -0.36 1.57e-9 Bipolar disorder (body mass index interaction); CESC cis rs17253792 0.822 rs77182097 chr14:56136695 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg19592336 chr6:28129416 ZNF389 0.53 6.92 0.39 3.43e-11 Parkinson's disease; CESC cis rs3733585 0.673 rs7377578 chr4:9952775 T/C cg11266682 chr4:10021025 SLC2A9 -0.57 -10.99 -0.56 2.07e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6831352 0.879 rs2851255 chr4:100042103 C/G cg13256891 chr4:100009986 ADH5 0.67 7.56 0.42 6.5e-13 Alcohol dependence; CESC cis rs909002 0.772 rs12740754 chr1:32083273 G/C cg13919466 chr1:32135498 COL16A1 -0.47 -8.41 -0.46 2.54e-15 Intelligence (multi-trait analysis); CESC cis rs7264396 0.563 rs7264869 chr20:34346502 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.68 7.34 0.41 2.59e-12 Total cholesterol levels; CESC cis rs4969178 0.965 rs11077364 chr17:76400337 C/A cg05887092 chr17:76393375 PGS1 0.58 9.26 0.49 7e-18 HDL cholesterol levels; CESC cis rs16854884 0.632 rs4563409 chr3:143682122 T/G cg06585982 chr3:143692056 C3orf58 0.51 6.27 0.36 1.49e-9 Economic and political preferences (feminism/equality); CESC cis rs644799 0.965 rs10831425 chr11:95500628 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.57 7.19 0.4 6.45e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg05340658 chr4:99064831 C4orf37 0.84 12.75 0.62 2.34e-29 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.1 -0.35 3.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs78456975 0.941 rs6755875 chr2:1557109 T/C cg01028140 chr2:1542097 TPO -0.51 -5.47 -0.32 1.07e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs12477438 0.520 rs11685759 chr2:99766217 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.04 0.68 2.28e-37 Chronic sinus infection; CESC cis rs59918340 0.728 rs59172574 chr8:142231945 C/G cg16341495 chr8:142228727 SLC45A4 -0.44 -5.29 -0.31 2.54e-7 Immature fraction of reticulocytes; CESC cis rs2012796 1.000 rs8008024 chr14:81818492 A/G cg02996355 chr14:81879375 NA 0.57 6.92 0.39 3.41e-11 Night sleep phenotypes; CESC cis rs6460942 0.908 rs112049544 chr7:12242551 A/G cg06484146 chr7:12443880 VWDE -0.63 -6.27 -0.36 1.44e-9 Coronary artery disease; CESC cis rs4728302 0.608 rs10254118 chr7:133158353 T/A cg10665199 chr7:133106180 EXOC4 0.53 7.37 0.41 2.16e-12 Intelligence;Intelligence (multi-trait analysis); CESC cis rs3733585 0.673 rs4407505 chr4:9953367 T/G cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4704187 0.687 rs11957125 chr5:74527639 G/A cg03227963 chr5:74354835 NA 0.28 5.08 0.3 7.28e-7 Response to amphetamines; CESC cis rs3892630 0.588 rs7260037 chr19:33242701 G/A cg13157960 chr19:33183277 NUDT19 0.53 5.33 0.31 2.09e-7 Red blood cell traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02469461 chr2:231589895 CAB39 -0.53 -6.56 -0.37 2.85e-10 Gut microbiome composition (summer); CESC cis rs137603 0.602 rs9611146 chr22:39718120 G/T cg01093212 chr22:39715156 SNORD43;RPL3 -0.42 -5.41 -0.32 1.39e-7 Primary biliary cholangitis; CESC cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.48 0.42 1.09e-12 Tonsillectomy; CESC cis rs1552244 0.554 rs17050705 chr3:10046398 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -7.26 -0.41 4.31e-12 Alzheimer's disease; CESC cis rs4780401 0.609 rs35902600 chr16:11800848 C/T cg01061890 chr16:11836724 TXNDC11 -0.55 -7.52 -0.42 8.39e-13 Rheumatoid arthritis; CESC cis rs9399135 0.967 rs4896122 chr6:135295081 T/C cg24558204 chr6:135376177 HBS1L 0.5 6.75 0.38 9.09e-11 Red blood cell count; CESC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg17949981 chr6:28129498 ZNF389 0.45 5.71 0.33 3.07e-8 Depression; CESC cis rs8070740 0.731 rs1071648 chr17:5326089 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.44 0.37 5.73e-10 Menopause (age at onset); CESC cis rs7264396 0.635 rs6060660 chr20:34476649 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.45 0.42 1.31e-12 Total cholesterol levels; CESC cis rs710216 0.843 rs2297972 chr1:43418026 C/T cg03128534 chr1:43423976 SLC2A1 -0.6 -7.66 -0.43 3.55e-13 Red cell distribution width; CESC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.83 8.32 0.46 4.56e-15 Platelet count; CESC cis rs1483890 0.723 rs6807930 chr3:69411662 C/T cg22125112 chr3:69402811 FRMD4B 0.38 5.11 0.3 6.08e-7 Resting heart rate; CESC cis rs6460942 0.597 rs7778131 chr7:12543233 T/G cg20607287 chr7:12443886 VWDE -0.71 -7.41 -0.41 1.69e-12 Coronary artery disease; CESC cis rs7017914 0.967 rs10448014 chr8:71688165 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs7712401 0.601 rs246320 chr5:122308581 A/G cg19412675 chr5:122181750 SNX24 0.41 5.18 0.3 4.51e-7 Mean platelet volume; CESC cis rs7762018 1.000 rs17860606 chr6:170099561 G/A cg05834625 chr6:170176447 C6orf70 0.63 7.65 0.43 3.62e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs151234 0.741 rs11644791 chr16:28601186 G/C cg01378222 chr16:28622494 SULT1A1 -0.57 -7.18 -0.4 7.06e-12 Platelet distribution width; CESC cis rs796364 1.000 rs281774 chr2:200814572 C/T cg23649088 chr2:200775458 C2orf69 0.54 5.13 0.3 5.5e-7 Schizophrenia; CESC cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg09997546 chr11:8931473 C11orf17;ST5 0.37 6.03 0.35 5.45e-9 Hemoglobin concentration; CESC cis rs9811920 0.715 rs6776886 chr3:99906270 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.38 5.84 0.34 1.5e-8 Axial length; CESC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.46 -0.54 1.15e-21 Alzheimer's disease; CESC cis rs35110281 0.811 rs9980185 chr21:45057905 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -8.76 -0.47 2.44e-16 Mean corpuscular volume; CESC cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs10208940 0.920 rs13400463 chr2:68723912 G/A cg12452813 chr2:68675892 NA 0.52 5.24 0.31 3.26e-7 Urate levels in lean individuals; CESC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg06634786 chr22:41940651 POLR3H 0.65 6.63 0.38 1.82e-10 Vitiligo; CESC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg17143192 chr8:8559678 CLDN23 -0.7 -7.92 -0.44 6.41e-14 Obesity-related traits; CESC cis rs4253772 0.514 rs11704878 chr22:46714664 C/T cg10541313 chr22:46663664 TTC38 0.68 5.11 0.3 6.09e-7 LDL cholesterol;Cholesterol, total; CESC cis rs1878931 0.501 rs9302871 chr16:3415512 T/C cg22508957 chr16:3507546 NAT15 -0.38 -5.55 -0.32 7.02e-8 Body mass index (adult); CESC trans rs921968 0.542 rs630858 chr2:219409689 C/A cg15547669 chr20:2781122 CPXM1 0.35 6.0 0.35 6.31e-9 Mean corpuscular hemoglobin concentration; CESC cis rs2645694 0.626 rs2703120 chr4:77822470 G/A cg18351406 chr4:77819688 ANKRD56 0.51 6.36 0.36 8.93e-10 Emphysema distribution in smoking; CESC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4330281 0.666 rs10433560 chr3:17803974 C/T cg20981856 chr3:17787350 NA 0.38 5.35 0.31 1.87e-7 Schizophrenia; CESC cis rs17401966 0.838 rs2182326 chr1:10385664 G/A cg15208524 chr1:10270712 KIF1B 0.42 5.43 0.32 1.26e-7 Hepatocellular carcinoma; CESC cis rs1707322 1.000 rs785468 chr1:46521517 G/A cg06784218 chr1:46089804 CCDC17 -0.33 -5.65 -0.33 4.08e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2063714 0.532 rs2063713 chr6:157196299 G/T cg23222435 chr6:157204239 ARID1B -0.57 -7.21 -0.4 5.86e-12 Sitting height ratio; CESC cis rs1983891 0.908 rs2148342 chr6:41519522 G/A cg20194872 chr6:41519635 FOXP4 0.58 8.33 0.46 4.25e-15 Prostate cancer; CESC trans rs1814175 0.645 rs7119101 chr11:49955665 G/A cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs9611565 0.840 rs9607799 chr22:41777558 A/G cg03806693 chr22:41940476 POLR3H -1.07 -13.24 -0.63 4.71e-31 Vitiligo; CESC cis rs9300255 0.516 rs6488868 chr12:123799974 A/G cg05973401 chr12:123451056 ABCB9 0.45 5.16 0.3 4.88e-7 Neutrophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25723933 chr1:155099956 EFNA1 -0.46 -6.06 -0.35 4.77e-9 Fibrinogen levels; CESC trans rs76747430 0.504 rs739183 chr22:40673685 T/C cg06617692 chr9:80262196 GNA14 0.54 6.02 0.35 5.89e-9 Facial morphology (factor 20); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02955050 chr19:59070391 UBE2M;LOC100131691 0.57 6.62 0.38 2.04e-10 Gut microbiome composition (summer); CESC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg17372223 chr3:52568218 NT5DC2 -0.38 -5.45 -0.32 1.15e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02730322 chr20:43150917 SERINC3 -0.61 -7.28 -0.41 3.84e-12 Gut microbiome composition (summer); CESC cis rs12824058 0.831 rs11608407 chr12:130805869 G/A cg23887609 chr12:130822674 PIWIL1 0.45 5.66 0.33 3.87e-8 Menopause (age at onset); CESC cis rs5769707 0.967 rs2071904 chr22:50034477 C/T cg20744362 chr22:50050164 C22orf34 0.48 8.27 0.45 6.61e-15 Monocyte count;Monocyte percentage of white cells; CESC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg17724175 chr1:150552817 MCL1 0.33 5.09 0.3 6.88e-7 Melanoma; CESC cis rs3733585 0.781 rs13103690 chr4:9972778 T/G cg11266682 chr4:10021025 SLC2A9 -0.61 -12.17 -0.6 2.26e-27 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1153858 1.000 rs3809472 chr15:45694318 G/T cg21132104 chr15:45694354 SPATA5L1 0.86 11.67 0.58 1.14e-25 Homoarginine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10387458 chr1:93645817 TMED5;CCDC18 0.58 6.98 0.39 2.39e-11 Gut microbiome composition (summer); CESC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg23172400 chr8:95962367 TP53INP1 -0.5 -10.43 -0.54 1.43e-21 Type 2 diabetes; CESC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg24250549 chr1:154909240 PMVK -0.7 -10.6 -0.55 4.18e-22 Prostate cancer; CESC cis rs4711336 0.935 rs3818529 chr6:33661106 T/C cg14003231 chr6:33640908 ITPR3 0.31 5.25 0.31 3.08e-7 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02759888 chr15:63449753 RPS27L -0.43 -6.11 -0.35 3.63e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs61841072 0.961 rs12131267 chr1:243138336 G/A cg02356786 chr1:243265016 LOC731275 0.42 5.34 0.31 2.03e-7 Schizophrenia; CESC cis rs4450798 0.649 rs9847246 chr3:13778888 C/T cg23332027 chr3:13681764 NA 0.4 5.59 0.32 5.77e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6032067 0.777 rs55767422 chr20:43802497 A/G cg11264863 chr20:43835661 SEMG1 0.5 5.38 0.31 1.62e-7 Blood protein levels; CESC cis rs887829 0.569 rs7574296 chr2:234638249 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.56 -7.66 -0.43 3.59e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs1879734 0.636 rs1879732 chr1:54175909 C/T cg23596471 chr1:54105337 GLIS1 0.32 5.17 0.3 4.7e-7 Mitral valve prolapse; CESC cis rs3741404 0.512 rs4980504 chr11:63873083 G/A cg18225595 chr11:63971243 STIP1 -0.45 -5.76 -0.33 2.27e-8 Platelet count; CESC cis rs2732480 0.557 rs2634682 chr12:48732943 T/C cg24011408 chr12:48396354 COL2A1 0.42 5.76 0.33 2.27e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs317689 0.819 rs317677 chr12:69691806 G/A cg14784868 chr12:69753453 YEATS4 0.49 5.29 0.31 2.53e-7 Response to diuretic therapy; CESC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg11494091 chr17:61959527 GH2 0.72 12.28 0.6 9.87e-28 Prudent dietary pattern; CESC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg10691866 chr7:65817282 TPST1 -0.33 -5.48 -0.32 1e-7 Aortic root size; CESC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg27266027 chr21:40555129 PSMG1 0.43 5.25 0.31 3.13e-7 Cognitive function; CESC cis rs11166629 0.502 rs6577717 chr8:135653832 G/T cg27224718 chr8:135614730 ZFAT 0.42 5.23 0.31 3.44e-7 Smoking quantity; CESC cis rs9291683 0.546 rs4529049 chr4:10045389 C/T cg00071950 chr4:10020882 SLC2A9 0.82 13.84 0.65 3.86e-33 Bone mineral density; CESC trans rs2727020 0.553 rs11040400 chr11:49518296 C/A cg15704280 chr7:45808275 SEPT13 -0.93 -15.36 -0.69 1.63e-38 Coronary artery disease; CESC cis rs6690583 0.623 rs6672362 chr1:85454881 C/G cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs2011503 0.941 rs56135441 chr19:19371370 A/T cg11584989 chr19:19387371 SF4 0.61 7.33 0.41 2.78e-12 Bipolar disorder; CESC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg26314531 chr2:26401878 FAM59B -0.83 -9.26 -0.49 7.37e-18 Gut microbiome composition (summer); CESC cis rs7586673 0.578 rs6723840 chr2:161879615 G/T cg08807892 chr2:162101083 NA 0.4 5.09 0.3 6.64e-7 Intelligence (multi-trait analysis); CESC cis rs7208859 0.673 rs9914271 chr17:29232625 G/A cg19761014 chr17:28927070 LRRC37B2 0.64 5.32 0.31 2.2e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7089973 0.604 rs7920216 chr10:116611794 G/A cg25233709 chr10:116636983 FAM160B1 0.38 5.98 0.34 7.26e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08555112 chr17:48942811 TOB1 -0.49 -7.34 -0.41 2.7e-12 Gambling; CESC cis rs6032067 0.929 rs6017510 chr20:43831785 A/G cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.56e-7 Blood protein levels; CESC cis rs7408868 0.831 rs1548555 chr19:15278057 A/G cg14696996 chr19:15285081 NOTCH3 1.11 11.94 0.59 1.43e-26 Pulse pressure; CESC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg26314531 chr2:26401878 FAM59B 0.86 9.09 0.49 2.34e-17 Gut microbiome composition (summer); CESC cis rs6484504 0.532 rs2616799 chr11:31319044 T/C cg14844989 chr11:31128820 NA 0.4 5.49 0.32 9.59e-8 Red blood cell count; CESC cis rs12410462 0.581 rs7547204 chr1:227560909 C/T cg23173402 chr1:227635558 NA 0.63 5.4 0.32 1.46e-7 Major depressive disorder; CESC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg27572855 chr1:25598939 RHD 0.44 7.25 0.41 4.5e-12 Erythrocyte sedimentation rate; CESC cis rs9915657 0.870 rs4140903 chr17:70133771 C/T cg09344028 chr17:70110421 NA 0.34 6.15 0.35 2.88e-9 Thyroid hormone levels; CESC cis rs4474465 0.790 rs4945293 chr11:78254554 T/C cg27205649 chr11:78285834 NARS2 0.42 5.32 0.31 2.16e-7 Alzheimer's disease (survival time); CESC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg12463550 chr7:65579703 CRCP 0.49 6.27 0.36 1.45e-9 Aortic root size; CESC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg10053473 chr17:62856997 LRRC37A3 -0.66 -9.2 -0.49 1.13e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4237845 0.591 rs10431506 chr12:58311524 G/A cg00677455 chr12:58241039 CTDSP2 0.54 6.38 0.36 7.84e-10 Intelligence (multi-trait analysis); CESC cis rs12497850 0.829 rs8926 chr3:49052785 T/A cg07636037 chr3:49044803 WDR6 1.05 19.08 0.76 1.13e-51 Parkinson's disease; CESC cis rs854765 0.647 rs2974999 chr17:17997547 T/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 5.92 0.34 9.86e-9 Total body bone mineral density; CESC cis rs75477785 0.590 rs11119388 chr1:210174417 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.23 0.36 1.82e-9 Cleft lip with or without cleft palate; CESC cis rs3740540 0.507 rs942015 chr10:126289932 G/T cg04949429 chr10:126290192 LHPP 0.38 5.27 0.31 2.78e-7 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs568617 0.953 rs583887 chr11:65644027 T/C cg00576331 chr11:65640516 EFEMP2 0.45 5.3 0.31 2.48e-7 Crohn's disease; CESC cis rs3105593 1.000 rs62017189 chr15:50922032 T/A cg08437265 chr15:50716283 USP8 0.41 5.25 0.31 3.18e-7 QT interval; CESC cis rs6963495 0.818 rs117887993 chr7:105193837 T/G cg19920283 chr7:105172520 RINT1 0.68 6.27 0.36 1.47e-9 Bipolar disorder (body mass index interaction); CESC cis rs9815354 0.812 rs111967505 chr3:41873157 C/T cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.83e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs11122272 0.735 rs910822 chr1:231498721 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.65 -0.43 3.62e-13 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08940762 chr2:233415810 TIGD1;EIF4E2 0.57 6.24 0.36 1.71e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06622735 chr5:473452 SLC9A3;LOC25845 0.61 6.71 0.38 1.16e-10 Gut microbiome composition (summer); CESC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.58 -0.37 2.43e-10 Life satisfaction; CESC cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg20476274 chr7:133979776 SLC35B4 0.69 10.23 0.53 6.57e-21 Mean platelet volume; CESC cis rs1790761 0.806 rs7114510 chr11:67224594 C/T cg14500267 chr11:67383377 NA 0.32 5.36 0.31 1.83e-7 Mean corpuscular volume; CESC cis rs12220238 1.000 rs7081350 chr10:75990328 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.03 0.35 5.57e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg03517284 chr6:25882590 NA -0.66 -9.34 -0.5 4.11e-18 Intelligence (multi-trait analysis); CESC cis rs2952156 0.920 rs2941506 chr17:37833035 A/G cg20243544 chr17:37824526 PNMT 0.63 8.01 0.44 3.74e-14 Asthma; CESC trans rs629535 0.725 rs639127 chr8:70073251 A/G cg21567404 chr3:27674614 NA 0.88 10.34 0.54 2.74e-21 Dupuytren's disease; CESC cis rs4237845 0.967 rs4553410 chr12:58301211 G/A cg02175503 chr12:58329896 NA 0.64 8.5 0.46 1.43e-15 Intelligence (multi-trait analysis); CESC cis rs72781680 1.000 rs72788280 chr2:24095907 A/G cg20701182 chr2:24300061 SF3B14 0.62 5.68 0.33 3.54e-8 Lymphocyte counts; CESC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg27170947 chr2:26402098 FAM59B -0.58 -6.79 -0.38 7.52e-11 Gut microbiome composition (summer); CESC cis rs2839186 0.504 rs11702278 chr21:47936295 T/G cg12379764 chr21:47803548 PCNT 0.64 8.84 0.48 1.34e-16 Testicular germ cell tumor; CESC cis rs6693567 0.507 rs9436120 chr1:150473084 T/C cg09579323 chr1:150459698 TARS2 0.47 5.73 0.33 2.76e-8 Migraine; CESC cis rs3026101 0.671 rs3026140 chr17:5313522 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.41 5.31 0.31 2.29e-7 Body mass index; CESC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg22029157 chr1:209979665 IRF6 0.76 8.72 0.47 3.02e-16 Cleft lip with or without cleft palate; CESC cis rs17376456 0.569 rs12653528 chr5:93212833 T/C cg25358565 chr5:93447407 FAM172A -0.71 -7.53 -0.42 7.86e-13 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11741956 chr14:103438353 CDC42BPB -0.64 -6.96 -0.39 2.75e-11 Gut microbiome composition (summer); CESC trans rs2235573 0.570 rs5995529 chr22:38415721 A/G cg19894588 chr14:64061835 NA -0.52 -6.65 -0.38 1.64e-10 Glioblastoma;Glioma; CESC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg18876405 chr7:65276391 NA 0.49 6.55 0.37 3e-10 Aortic root size; CESC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg12373951 chr3:133503437 NA -0.43 -6.27 -0.36 1.42e-9 Iron status biomarkers; CESC cis rs2273669 0.667 rs16822 chr6:109307710 G/A cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC cis rs2197308 0.605 rs2387437 chr12:37919367 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.78 0.33 2.05e-8 Morning vs. evening chronotype; CESC cis rs9322193 0.884 rs9688858 chr6:149959047 C/A cg13206674 chr6:150067644 NUP43 0.4 5.68 0.33 3.59e-8 Lung cancer; CESC cis rs7605827 0.930 rs13035283 chr2:15500939 G/C cg19274914 chr2:15703543 NA 0.33 5.91 0.34 1.03e-8 Educational attainment (years of education); CESC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs4253772 0.530 rs9615961 chr22:46754993 T/C cg00784671 chr22:46762841 CELSR1 -0.64 -6.18 -0.36 2.35e-9 LDL cholesterol;Cholesterol, total; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04674497 chr6:45346044 SUPT3H;RUNX2 0.48 6.18 0.35 2.44e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs13133355 chr4:98919415 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.32 0.31 2.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC cis rs2228479 0.867 rs62056110 chr16:89946388 A/C cg06558623 chr16:89946397 TCF25 1.06 8.98 0.48 5.17e-17 Skin colour saturation; CESC trans rs8073060 0.544 rs1080352 chr17:34002362 A/G cg19694781 chr19:47549865 TMEM160 -0.73 -7.2 -0.4 6.17e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg11965913 chr1:205819406 PM20D1 0.82 13.95 0.65 1.49e-33 Menarche (age at onset); CESC cis rs4888262 0.526 rs8057279 chr16:74627303 C/T cg01733217 chr16:74700730 RFWD3 0.85 11.48 0.58 4.93e-25 Testicular germ cell tumor; CESC cis rs7122539 0.506 rs11227625 chr11:66684151 T/G cg24851651 chr11:66362959 CCS 0.39 5.73 0.33 2.71e-8 HIV-1 susceptibility; CESC cis rs7772486 0.806 rs4075695 chr6:146250959 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -10.89 -0.56 4.58e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs3812762 0.879 rs4929934 chr11:8777789 A/G cg03980550 chr11:8754370 ST5 0.35 5.1 0.3 6.47e-7 Hypospadias; CESC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg11941060 chr3:133502564 NA -0.48 -6.65 -0.38 1.67e-10 Iron status biomarkers; CESC cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg21951975 chr1:209979733 IRF6 0.59 7.16 0.4 8.01e-12 Cleft lip with or without cleft palate; CESC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg22143856 chr6:28129313 ZNF389 0.39 5.17 0.3 4.57e-7 Parkinson's disease; CESC cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg03146154 chr1:46216737 IPP -0.45 -5.58 -0.32 5.83e-8 High light scatter reticulocyte count; CESC cis rs11122272 0.735 rs2739510 chr1:231526718 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.12 0.35 3.28e-9 Hemoglobin concentration; CESC cis rs6732160 0.613 rs10179063 chr2:73385111 T/A cg01422370 chr2:73384389 NA 0.56 8.74 0.47 2.67e-16 Intelligence (multi-trait analysis); CESC cis rs3749237 0.595 rs17595772 chr3:49409704 G/A cg02487422 chr3:49467188 NICN1 0.55 7.98 0.44 4.56e-14 Resting heart rate; CESC trans rs208520 0.690 rs4710564 chr6:66823478 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 10.82 0.55 7.79e-23 Exhaled nitric oxide output; CESC cis rs2228479 0.850 rs12597296 chr16:89822331 C/T cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg18876405 chr7:65276391 NA 0.53 7.28 0.41 3.9e-12 Aortic root size; CESC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.08 -0.53 2.01e-20 Alzheimer's disease; CESC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg19077165 chr18:44547161 KATNAL2 -0.61 -9.16 -0.49 1.5e-17 Personality dimensions; CESC cis rs9614461 0.702 rs3788648 chr22:45727180 G/A cg22884516 chr22:45809543 SMC1B;RIBC2 0.56 5.15 0.3 4.98e-7 Tonsillectomy; CESC cis rs965469 0.779 rs6515791 chr20:3310443 C/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.41 -0.32 1.42e-7 IFN-related cytopenia; CESC cis rs2204008 0.744 rs8189486 chr12:38244968 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.3 0.36 1.24e-9 Bladder cancer; CESC cis rs59918340 0.509 rs11784862 chr8:142203452 T/C cg18755752 chr8:142205143 DENND3 -0.44 -5.6 -0.33 5.34e-8 Immature fraction of reticulocytes; CESC cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg03060546 chr3:49711283 APEH 0.64 7.34 0.41 2.55e-12 Menarche (age at onset); CESC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg10053473 chr17:62856997 LRRC37A3 -0.7 -7.4 -0.41 1.78e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg24818145 chr4:99064322 C4orf37 0.39 5.1 0.3 6.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12220238 1.000 rs12256105 chr10:75909634 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.66 6.68 0.38 1.42e-10 Soluble interleukin-2 receptor subunit alpha; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00102808 chr16:620304 PIGQ 0.56 6.35 0.36 9.1e-10 Gut microbiome composition (summer); CESC cis rs10206020 0.921 rs72778005 chr2:1573122 C/G cg26248373 chr2:1572462 NA -0.59 -6.98 -0.39 2.31e-11 IgG glycosylation; CESC cis rs4820539 1.000 rs3788347 chr22:23467804 G/A cg14186256 chr22:23484241 RTDR1 0.81 14.66 0.67 4.99e-36 Bone mineral density; CESC cis rs9341808 0.621 rs2322627 chr6:80806341 T/A cg08355045 chr6:80787529 NA 0.33 5.12 0.3 5.88e-7 Sitting height ratio; CESC cis rs2708240 1.000 rs2710105 chr7:147574236 G/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.23e-8 QT interval (drug interaction); CESC cis rs34638657 0.872 rs7202258 chr16:82195013 T/C cg09439754 chr16:82129088 HSD17B2 -0.37 -5.42 -0.32 1.33e-7 Lung adenocarcinoma; CESC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg16262614 chr3:133464971 TF -0.3 -5.67 -0.33 3.81e-8 Iron status biomarkers; CESC cis rs3857536 0.813 rs7770349 chr6:66946659 G/T cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs4839827 1 rs4839827 chr6:96853967 C/T cg06623918 chr6:96969491 KIAA0776 0.62 8.44 0.46 2.05e-15 Migraine; CESC cis rs1538970 0.961 rs4660854 chr1:45854087 A/T cg24296786 chr1:45957014 TESK2 -0.45 -5.45 -0.32 1.13e-7 Platelet count; CESC cis rs9768139 0.733 rs13225172 chr7:158120334 G/A cg25566285 chr7:158114605 PTPRN2 0.47 7.32 0.41 2.89e-12 Calcium levels; CESC cis rs9768139 0.935 rs10155946 chr7:158122116 C/T cg25566285 chr7:158114605 PTPRN2 -0.49 -8.35 -0.46 3.88e-15 Calcium levels; CESC cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7147624 1.000 rs2411349 chr14:66214426 T/C cg03016385 chr14:66212404 NA -0.5 -5.25 -0.31 3.1e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs11229030 0.893 rs2581925 chr11:57207414 G/A cg00522883 chr11:57194120 SLC43A3 -0.45 -5.93 -0.34 9.44e-9 Crohn's disease; CESC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.48 -6.02 -0.35 5.68e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.34 -0.36 9.62e-10 Bipolar disorder; CESC cis rs6982240 0.569 rs6992278 chr8:142279383 C/G cg00131261 chr8:142287264 NA -0.5 -7.33 -0.41 2.82e-12 Tonsillectomy; CESC cis rs6430585 0.583 rs7581814 chr2:136641593 C/G cg07169764 chr2:136633963 MCM6 -1.27 -19.97 -0.78 9.06e-55 Corneal structure; CESC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg17372223 chr3:52568218 NT5DC2 0.42 6.42 0.37 6.33e-10 Bipolar disorder; CESC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg18016565 chr1:150552671 MCL1 0.33 5.16 0.3 4.96e-7 Tonsillectomy; CESC cis rs116095464 0.558 rs9312978 chr5:221930 C/G cg16372103 chr5:203701 NA 0.49 5.29 0.31 2.58e-7 Breast cancer; CESC cis rs7833986 0.501 rs72653990 chr8:57037115 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 7e-13 Height; CESC cis rs60843830 1.000 rs114976176 chr2:264621 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.82 10.69 0.55 2.14e-22 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9814567 0.929 rs9815297 chr3:134215052 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.41 -5.67 -0.33 3.79e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg12311346 chr5:56204834 C5orf35 -0.7 -8.58 -0.47 8.32e-16 Initial pursuit acceleration; CESC cis rs748404 0.660 rs2467741 chr15:43742626 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.23 0.45 8.36e-15 Lung cancer; CESC cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg21573476 chr21:45109991 RRP1B 0.57 8.69 0.47 3.9e-16 Mean corpuscular volume; CESC cis rs910316 0.763 rs175014 chr14:75456927 A/G cg16144293 chr14:75469539 EIF2B2 0.39 5.12 0.3 6.02e-7 Height; CESC cis rs2204008 0.583 rs12820907 chr12:37990931 T/C cg26384229 chr12:38710491 ALG10B 0.66 9.47 0.5 1.58e-18 Bladder cancer; CESC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg03709012 chr19:19516395 GATAD2A -0.93 -13.62 -0.64 2.27e-32 Tonsillectomy; CESC cis rs2204008 0.777 rs114096617 chr12:38342557 A/C cg26384229 chr12:38710491 ALG10B 0.73 10.93 0.56 3.37e-23 Bladder cancer; CESC cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.87 13.96 0.65 1.39e-33 Hip circumference adjusted for BMI; CESC cis rs892961 0.899 rs3650 chr17:75415835 T/C cg05865280 chr17:75406074 SEPT9 0.63 12.68 0.61 4.09e-29 Airflow obstruction; CESC cis rs9814567 1.000 rs6782563 chr3:134295959 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.41 5.52 0.32 8.13e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.15e-9 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04571742 chr3:51534000 VPRBP 0.46 6.25 0.36 1.67e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs868036 0.645 rs4776972 chr15:68083436 A/C cg24579218 chr15:68104479 NA -0.36 -5.05 -0.3 8.31e-7 Restless legs syndrome; CESC trans rs1814175 0.791 rs10839468 chr11:49986288 A/G cg15704280 chr7:45808275 SEPT13 -1.05 -20.9 -0.79 5.74e-58 Height; CESC cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg24110177 chr3:50126178 RBM5 0.58 8.17 0.45 1.28e-14 Body mass index; CESC cis rs7264396 0.561 rs2050930 chr20:34579397 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -6.81 -0.39 6.41e-11 Total cholesterol levels; CESC cis rs10416265 0.503 rs1981818 chr19:33615122 C/T cg17764715 chr19:33622953 WDR88 -0.58 -8.46 -0.46 1.88e-15 Bone properties (heel); CESC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.3 -0.53 3.74e-21 Alzheimer's disease; CESC cis rs12477438 0.520 rs2632277 chr2:99778985 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.85 14.9 0.68 6.73e-37 Chronic sinus infection; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26027482 chr12:1100598 ERC1 -0.46 -6.38 -0.36 7.66e-10 Gambling; CESC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.7 0.38 1.22e-10 Bipolar disorder; CESC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg04944784 chr2:26401820 FAM59B -0.96 -10.55 -0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs12477438 0.559 rs6733285 chr2:99725575 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 12.89 0.62 7.58e-30 Chronic sinus infection; CESC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg11663144 chr21:46675770 NA -0.6 -9.45 -0.5 1.9e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7911712 0.515 rs1771996 chr10:45258544 T/C cg12743970 chr17:64536520 PRKCA -0.62 -6.03 -0.35 5.6e-9 Emphysema-related traits; CESC cis rs9611565 0.694 rs202622 chr22:41825342 T/G cg03806693 chr22:41940476 POLR3H 1.2 14.53 0.67 1.4e-35 Vitiligo; CESC cis rs1003719 0.788 rs2835577 chr21:38457457 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.67 0.47 4.41e-16 Eye color traits; CESC cis rs6088590 0.931 rs12625149 chr20:33425812 A/C cg24642439 chr20:33292090 TP53INP2 -0.75 -10.05 -0.53 2.34e-20 Coronary artery disease; CESC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg24634471 chr8:143751801 JRK 0.43 5.18 0.3 4.38e-7 Urinary tract infection frequency; CESC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.25 -0.53 5.42e-21 Alzheimer's disease; CESC cis rs854765 0.647 rs854790 chr17:18028318 C/G cg16928487 chr17:17741425 SREBF1 -0.37 -5.48 -0.32 1.01e-7 Total body bone mineral density; CESC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs6547741 0.874 rs58737572 chr2:27852118 A/C cg21248554 chr2:27665150 KRTCAP3 0.25 5.08 0.3 7.27e-7 Oral cavity cancer; CESC cis rs7607369 0.648 rs7599984 chr2:219656713 T/G cg02176678 chr2:219576539 TTLL4 -0.48 -8.21 -0.45 9.44e-15 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs10870270 0.956 rs10781555 chr10:133745720 G/A cg26149184 chr10:133730230 NA 0.37 5.09 0.3 6.85e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2708240 0.905 rs2710108 chr7:147574174 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.23e-8 QT interval (drug interaction); CESC cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg11752832 chr7:134001865 SLC35B4 0.54 7.09 0.4 1.19e-11 Mean platelet volume; CESC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg05585544 chr11:47624801 NA 0.48 7.13 0.4 9.42e-12 Subjective well-being; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08052428 chr9:135996421 RALGDS 0.48 6.38 0.36 8.03e-10 Gut microbiota (bacterial taxa); CESC cis rs96067 0.805 rs4652902 chr1:36612955 C/A cg24686825 chr1:36642396 MAP7D1 -0.5 -5.51 -0.32 8.44e-8 Corneal structure; CESC cis rs225245 0.755 rs7217565 chr17:34024707 C/A cg05299278 chr17:33885742 SLFN14 0.38 5.51 0.32 8.62e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs1003719 0.762 rs3787787 chr21:38463452 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs9300255 0.698 rs4759416 chr12:123746357 C/G cg19016782 chr12:123741754 C12orf65 -0.5 -7.26 -0.41 4.27e-12 Neutrophil percentage of white cells; CESC cis rs6446731 0.734 rs7675084 chr4:3273908 C/T cg08886695 chr4:3369023 RGS12 -0.35 -5.1 -0.3 6.63e-7 Mean platelet volume; CESC cis rs7258465 0.965 rs2385088 chr19:18545540 A/G cg25828334 chr19:18545568 ISYNA1 -0.33 -5.28 -0.31 2.74e-7 Breast cancer; CESC cis rs868036 0.560 rs12443086 chr15:68080454 C/A cg08079166 chr15:68083412 MAP2K5 0.4 6.48 0.37 4.34e-10 Restless legs syndrome; CESC cis rs11785400 0.753 rs9694286 chr8:143737157 G/T cg24634471 chr8:143751801 JRK 0.46 5.94 0.34 9.01e-9 Schizophrenia; CESC cis rs4253772 0.550 rs715515 chr22:46720921 G/A cg10541313 chr22:46663664 TTC38 0.68 5.09 0.3 6.74e-7 LDL cholesterol;Cholesterol, total; CESC cis rs11098499 0.909 rs10017335 chr4:120381523 C/G cg24375607 chr4:120327624 NA -0.41 -5.03 -0.3 8.86e-7 Corneal astigmatism; CESC trans rs72996113 0.702 rs75760535 chr11:100519573 G/A cg20136100 chr11:63974860 FERMT3 -0.52 -6.58 -0.37 2.56e-10 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs6582630 0.555 rs10880612 chr12:38509427 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.91 0.34 1.03e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs2952156 0.920 rs2517955 chr17:37843681 C/T cg20243544 chr17:37824526 PNMT 0.63 8.1 0.45 1.99e-14 Asthma; CESC cis rs6460942 1.000 rs2033871 chr7:12405098 C/A cg02935154 chr7:12443704 VWDE -0.56 -6.1 -0.35 3.8e-9 Coronary artery disease; CESC cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg00409905 chr10:38381863 ZNF37A -0.48 -6.32 -0.36 1.12e-9 Extrinsic epigenetic age acceleration; CESC cis rs2273669 0.667 rs76201299 chr6:109344975 T/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.06 -0.35 4.74e-9 Prostate cancer; CESC cis rs28647808 1.000 rs28540113 chr9:136273463 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23773983 chr6:16761891 ATXN1 0.49 6.87 0.39 4.69e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7301826 0.966 rs10734980 chr12:131294626 T/C cg11011512 chr12:131303247 STX2 0.4 5.09 0.3 6.83e-7 Plasma plasminogen activator levels; CESC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg24578937 chr1:2090814 PRKCZ 0.33 5.9 0.34 1.13e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00140235 chr12:93323273 EEA1 0.51 6.24 0.36 1.7e-9 Gut microbiome composition (summer); CESC cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg01579765 chr21:45077557 HSF2BP -0.55 -9.0 -0.48 4.45e-17 Mean corpuscular volume; CESC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg06221963 chr1:154839813 KCNN3 -0.66 -11.32 -0.57 1.71e-24 Prostate cancer; CESC cis rs12451471 0.667 rs12942002 chr17:78101629 C/G cg24585782 chr17:78113791 EIF4A3 -0.62 -8.36 -0.46 3.47e-15 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg06212747 chr3:49208901 KLHDC8B 0.73 9.91 0.52 6.74e-20 Parkinson's disease; CESC cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg26373071 chr5:1325741 CLPTM1L 0.43 6.62 0.38 2.01e-10 Lung cancer; CESC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg06877462 chr1:205807181 PM20D1 0.39 5.96 0.34 8.07e-9 Menarche (age at onset); CESC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.17e-9 Menopause (age at onset); CESC cis rs5758659 0.652 rs133303 chr22:42395242 C/G cg15557168 chr22:42548783 NA -0.44 -6.47 -0.37 4.61e-10 Cognitive function; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg03168501 chr19:33211891 TDRD12 0.42 6.01 0.35 6.01e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7208859 0.623 rs9911490 chr17:29073013 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7210086 0.752 rs4072601 chr17:70641327 G/A cg04206342 chr17:70636940 NA -0.36 -5.19 -0.3 4.28e-7 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18125208 chr1:228297275 MRPL55 0.57 6.02 0.35 5.65e-9 Gut microbiome composition (summer); CESC cis rs16858210 0.874 rs6792309 chr3:183607661 C/T cg25686905 chr3:183603175 PARL -0.33 -6.05 -0.35 4.88e-9 Menopause (age at onset); CESC cis rs1953600 0.668 rs751740 chr10:81912179 T/C cg00277334 chr10:82204260 NA 0.4 5.49 0.32 9.32e-8 Sarcoidosis; CESC cis rs5758659 0.594 rs739292 chr22:42368857 G/A cg19513890 chr22:42538836 CYP2D7P1 -0.38 -5.27 -0.31 2.86e-7 Cognitive function; CESC cis rs2742234 0.590 rs2435338 chr10:43642115 A/G cg15436174 chr10:43711423 RASGEF1A -0.48 -5.61 -0.33 5.11e-8 Hirschsprung disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07628300 chr16:312565 ITFG3 -0.55 -6.07 -0.35 4.48e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs28451001 chr4:98924544 T/A cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs17253792 0.822 rs8013714 chr14:56172286 T/C cg01858014 chr14:56050164 KTN1 -0.62 -5.67 -0.33 3.78e-8 Putamen volume; CESC cis rs6460942 1.000 rs6460935 chr7:12401317 A/T cg20607287 chr7:12443886 VWDE -0.68 -7.81 -0.43 1.33e-13 Coronary artery disease; CESC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg13777783 chr17:79615861 NA -0.37 -6.2 -0.36 2.14e-9 Eye color traits; CESC cis rs17376456 0.597 rs10866760 chr5:93338335 G/A cg25358565 chr5:93447407 FAM172A -0.44 -5.17 -0.3 4.6e-7 Diabetic retinopathy; CESC cis rs7927771 1.000 rs4752857 chr11:47655752 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -5.98 -0.34 7.29e-9 Subjective well-being; CESC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg02951883 chr7:2050386 MAD1L1 -0.49 -6.44 -0.37 5.57e-10 Bipolar disorder and schizophrenia; CESC cis rs6546550 0.935 rs7563062 chr2:70050725 G/A cg02498382 chr2:70120550 SNRNP27 -0.39 -6.7 -0.38 1.25e-10 Prevalent atrial fibrillation; CESC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg27572855 chr1:25598939 RHD 0.5 8.45 0.46 1.99e-15 Erythrocyte sedimentation rate; CESC cis rs2933343 0.601 rs1680759 chr3:128594896 C/G cg24203234 chr3:128598194 ACAD9 0.43 5.88 0.34 1.23e-8 IgG glycosylation; CESC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg18876405 chr7:65276391 NA -0.55 -7.33 -0.41 2.71e-12 Aortic root size; CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg22834172 chr17:37774349 NA 0.54 6.2 0.36 2.15e-9 Endometrial cancer; CESC trans rs561341 1.000 rs55643307 chr17:30263074 T/C cg27661571 chr11:113659931 NA -0.83 -7.53 -0.42 7.89e-13 Hip circumference adjusted for BMI; CESC cis rs9467711 0.606 rs9379875 chr6:26444732 C/T cg12826209 chr6:26865740 GUSBL1 0.67 5.15 0.3 5.15e-7 Autism spectrum disorder or schizophrenia; CESC cis rs559928 0.606 rs57021319 chr11:63956102 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.82 0.34 1.7e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg24250549 chr1:154909240 PMVK 0.62 8.52 0.46 1.2e-15 Prostate cancer; CESC cis rs1372520 0.684 rs2583963 chr4:90727088 C/T cg15133208 chr4:90757351 SNCA -0.43 -5.79 -0.33 2.02e-8 Neuroticism; CESC cis rs763014 0.898 rs1981484 chr16:630710 A/G cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.35e-9 Height; CESC cis rs3733585 0.699 rs6449178 chr4:9968684 A/G cg11266682 chr4:10021025 SLC2A9 0.56 10.46 0.54 1.13e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg03709012 chr19:19516395 GATAD2A 1.0 15.51 0.69 4.72e-39 Tonsillectomy; CESC cis rs7772486 0.875 rs9403768 chr6:146406458 A/C cg23711669 chr6:146136114 FBXO30 0.85 12.48 0.61 2.01e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs6912958 1.000 rs6933587 chr6:88175577 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.43 -0.32 1.26e-7 Monocyte percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14782266 chr2:42565367 NA 0.47 6.19 0.36 2.28e-9 Fibrinogen levels; CESC cis rs3015497 1.000 rs4075253 chr14:51107737 G/A cg26011998 chr14:51135199 SAV1 -0.43 -5.47 -0.32 1.04e-7 Mean platelet volume; CESC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg25072359 chr17:41440525 NA 0.43 5.83 0.34 1.61e-8 Menopause (age at onset); CESC cis rs7666738 0.518 rs13133925 chr4:98706398 G/T cg05340658 chr4:99064831 C4orf37 0.54 6.56 0.37 2.81e-10 Colonoscopy-negative controls vs population controls; CESC cis rs804280 0.662 rs804283 chr8:11611043 G/A cg26752888 chr8:11627280 NEIL2 -0.67 -6.09 -0.35 4.02e-9 Myopia (pathological); CESC cis rs4835473 0.715 rs1849124 chr4:144899647 T/A cg25736465 chr4:144833511 NA 0.4 6.13 0.35 3.19e-9 Immature fraction of reticulocytes; CESC cis rs11252926 0.589 rs12359901 chr10:475068 A/G cg03684893 chr10:554711 DIP2C 0.37 5.42 0.32 1.35e-7 Psychosis in Alzheimer's disease; CESC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.39 0.61 4.17e-28 Alzheimer's disease; CESC cis rs9948 1.000 rs12172 chr2:97500852 C/G cg01990225 chr2:97406019 LMAN2L -0.75 -5.41 -0.32 1.44e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs2929278 0.561 rs62018952 chr15:44080737 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.54 -7.14 -0.4 8.76e-12 Schizophrenia; CESC cis rs6690583 0.623 rs2028304 chr1:85488030 G/A cg11262906 chr1:85462892 MCOLN2 -0.53 -5.26 -0.31 3.04e-7 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10654866 chr19:17631869 PGLS -0.54 -6.25 -0.36 1.62e-9 Gut microbiome composition (summer); CESC cis rs40363 0.951 rs72778117 chr16:3531827 T/C cg21433313 chr16:3507492 NAT15 0.67 8.22 0.45 9.05e-15 Tuberculosis; CESC cis rs7124681 0.565 rs2904127 chr11:47817290 A/G cg18512352 chr11:47633146 NA 0.35 5.33 0.31 2.05e-7 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs2637266 1.000 rs2579749 chr10:78332105 T/C cg18941641 chr10:78392320 NA 0.41 7.47 0.42 1.18e-12 Pulmonary function; CESC cis rs11676348 0.846 rs4674259 chr2:218991005 C/T cg00012203 chr2:219082015 ARPC2 -0.58 -7.5 -0.42 9.53e-13 Ulcerative colitis; CESC trans rs634534 0.622 rs1308733 chr11:65720841 T/C cg17712092 chr4:129076599 LARP1B -0.61 -7.85 -0.43 1.03e-13 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.87e-8 Lung cancer; CESC cis rs4689388 0.926 rs3821940 chr4:6286711 C/A cg25554036 chr4:6271136 WFS1 0.52 8.38 0.46 3.2e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9300255 0.543 rs655293 chr12:123528405 G/A cg00376283 chr12:123451042 ABCB9 0.77 9.26 0.49 7.28e-18 Neutrophil percentage of white cells; CESC cis rs17376456 0.825 rs10051878 chr5:93064164 T/G cg21475434 chr5:93447410 FAM172A 0.83 7.39 0.41 1.91e-12 Diabetic retinopathy; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.10.2686225R chr10:126090281 OAT -0.47 -6.16 -0.35 2.64e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs6011002 0.810 rs6010988 chr20:62278210 G/A cg17720233 chr1:151128310 TNFAIP8L2 0.84 6.21 0.36 2.07e-9 Dental caries; CESC cis rs3091242 0.933 rs34933589 chr1:25788198 T/C cg02931644 chr1:25747376 RHCE -0.39 -6.48 -0.37 4.53e-10 Erythrocyte sedimentation rate; CESC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg21226059 chr5:178986404 RUFY1 -0.52 -8.17 -0.45 1.31e-14 Lung cancer; CESC cis rs34638657 0.656 rs1134847 chr16:82203742 C/T cg09439754 chr16:82129088 HSD17B2 0.34 6.06 0.35 4.64e-9 Lung adenocarcinoma; CESC cis rs2066819 1.000 rs2371494 chr12:56728000 G/A cg26714650 chr12:56694279 CS -1.24 -14.98 -0.68 3.75e-37 Psoriasis vulgaris; CESC cis rs3857067 0.806 rs7676797 chr4:95099194 G/A cg11021082 chr4:95130006 SMARCAD1 -0.55 -8.05 -0.44 2.8e-14 QT interval; CESC trans rs61931739 0.534 rs11053014 chr12:34103519 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.18 0.45 1.17e-14 Morning vs. evening chronotype; CESC cis rs6542838 0.671 rs6752025 chr2:99505699 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.05 -0.3 8.25e-7 Fear of minor pain; CESC cis rs7267979 1.000 rs2257988 chr20:25270003 T/C cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.75 11.1 0.56 9.3e-24 Hip circumference adjusted for BMI; CESC cis rs7100689 0.577 rs1340385 chr10:82058851 G/A cg00277334 chr10:82204260 NA -0.51 -6.47 -0.37 4.6e-10 Post bronchodilator FEV1; CESC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg04944784 chr2:26401820 FAM59B -0.96 -10.55 -0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs644799 1.000 rs516551 chr11:95588626 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 13.43 0.64 1.02e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1642645 0.831 rs4660212 chr1:42496399 C/T cg16685388 chr1:42384056 HIVEP3 -0.37 -5.43 -0.32 1.26e-7 Left ventricular obstructive tract defect (maternal effect); CESC cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.83 7.04 0.4 1.61e-11 Initial pursuit acceleration; CESC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.76 0.38 8.76e-11 Bipolar disorder; CESC cis rs3793683 0.825 rs3793674 chr10:134555773 C/T cg26818010 chr10:134567672 INPP5A 0.47 5.87 0.34 1.27e-8 Migraine; CESC cis rs4253772 0.591 rs9615935 chr22:46686115 T/G cg10541313 chr22:46663664 TTC38 0.72 5.15 0.3 5.01e-7 LDL cholesterol;Cholesterol, total; CESC cis rs12780046 0.536 rs11190027 chr10:101012664 A/G cg27143070 chr10:101087766 CNNM1 0.38 5.65 0.33 4.22e-8 Non-glioblastoma glioma; CESC cis rs12476592 0.516 rs6717060 chr2:63568608 G/A cg17519650 chr2:63277830 OTX1 -0.46 -5.26 -0.31 3.03e-7 Childhood ear infection; CESC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs2011503 0.943 rs756997 chr19:19467085 G/C cg11584989 chr19:19387371 SF4 -0.65 -7.81 -0.43 1.35e-13 Bipolar disorder; CESC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg16325326 chr1:53192061 ZYG11B 0.82 12.75 0.62 2.35e-29 Monocyte count; CESC cis rs2439831 0.867 rs2584702 chr15:43684914 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.86 13.04 0.63 2.26e-30 Lung cancer in ever smokers; CESC cis rs11098499 0.780 rs7692994 chr4:120427489 C/A cg09307838 chr4:120376055 NA 0.88 11.82 0.59 3.48e-26 Corneal astigmatism; CESC cis rs7666738 0.519 rs13136069 chr4:98819568 C/T cg17366294 chr4:99064904 C4orf37 0.48 5.85 0.34 1.42e-8 Colonoscopy-negative controls vs population controls; CESC cis rs10883723 0.810 rs2296588 chr10:104248087 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.93e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg11764359 chr7:65958608 NA 0.81 11.89 0.59 2.11e-26 Aortic root size; CESC cis rs11871801 0.517 rs35635959 chr17:40772288 T/C cg14558262 chr17:40713999 COASY 0.5 5.83 0.34 1.58e-8 Crohn's disease; CESC cis rs6831352 0.877 rs2602890 chr4:100043179 C/T cg13256891 chr4:100009986 ADH5 0.75 8.31 0.45 5.11e-15 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01485948 chr17:2296549 MNT 0.61 7.19 0.4 6.62e-12 Gut microbiome composition (summer); CESC cis rs1559088 0.576 rs11084707 chr19:33612873 C/T cg03563238 chr19:33554763 RHPN2 -0.3 -5.58 -0.32 5.86e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs17433780 0.860 rs10922545 chr1:89492201 C/T cg09516651 chr1:89888402 LOC400759 0.68 9.49 0.5 1.43e-18 Carotid intima media thickness; CESC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg04267008 chr7:1944627 MAD1L1 -0.61 -7.4 -0.41 1.75e-12 Bipolar disorder and schizophrenia; CESC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC cis rs459571 0.959 rs392134 chr9:136909008 G/A cg13789015 chr9:136890014 NCRNA00094 0.56 8.03 0.44 3.28e-14 Platelet distribution width; CESC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -5.75 -0.33 2.46e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11958404 0.932 rs6859826 chr5:157429710 T/C cg05962755 chr5:157440814 NA 0.62 6.53 0.37 3.41e-10 IgG glycosylation; CESC cis rs3008870 0.959 rs4655658 chr1:67389608 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.02 14.08 0.65 5.61e-34 Lymphocyte percentage of white cells; CESC cis rs561341 0.941 rs8066156 chr17:30361629 A/G cg12193833 chr17:30244370 NA -0.51 -5.27 -0.31 2.88e-7 Hip circumference adjusted for BMI; CESC cis rs9399401 0.667 rs11759653 chr6:142720354 G/A cg04461802 chr6:142623433 GPR126 0.42 6.04 0.35 5.13e-9 Chronic obstructive pulmonary disease; CESC cis rs12476592 0.602 rs10865340 chr2:63824049 C/G cg17519650 chr2:63277830 OTX1 -0.46 -5.14 -0.3 5.28e-7 Childhood ear infection; CESC cis rs67311347 1.000 rs7633809 chr3:40517737 A/G cg09455208 chr3:40491958 NA -0.51 -8.72 -0.47 3.02e-16 Renal cell carcinoma; CESC cis rs8017423 0.967 rs7151776 chr14:90724803 A/G cg14092571 chr14:90743983 NA -0.53 -7.88 -0.44 8.28e-14 Mortality in heart failure; CESC cis rs524281 0.731 rs3814744 chr11:65809763 C/T cg14036092 chr11:66035641 RAB1B -0.57 -5.42 -0.32 1.37e-7 Electroencephalogram traits; CESC cis rs6493487 0.512 rs35416047 chr15:51188545 T/C cg02338191 chr15:51200825 AP4E1 0.6 5.58 0.32 5.79e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs412000 0.553 rs2680702 chr17:56431549 A/G cg12560992 chr17:57184187 TRIM37 0.59 7.21 0.41 5.69e-12 Primary tooth development (time to first tooth eruption); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05772935 chr16:1790400 MAPK8IP3 0.55 7.37 0.41 2.22e-12 Fibrinogen levels; CESC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg24549020 chr5:56110836 MAP3K1 0.45 5.76 0.33 2.31e-8 Initial pursuit acceleration; CESC cis rs7666738 0.830 rs9998582 chr4:98938949 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6754311 0.773 rs309130 chr2:136631031 C/A cg07169764 chr2:136633963 MCM6 -0.69 -8.48 -0.46 1.63e-15 Mosquito bite size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26860113 chr20:361741 TRIB3 0.58 6.47 0.37 4.76e-10 Gut microbiome composition (summer); CESC cis rs7618501 0.501 rs35275715 chr3:49959148 A/G cg24308560 chr3:49941425 MST1R -0.6 -8.79 -0.48 1.9e-16 Intelligence (multi-trait analysis); CESC trans rs2727020 0.658 rs4980431 chr11:49350071 G/T cg15704280 chr7:45808275 SEPT13 -0.87 -14.51 -0.67 1.67e-35 Coronary artery disease; CESC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg04267008 chr7:1944627 MAD1L1 -0.62 -7.57 -0.42 6.35e-13 Bipolar disorder and schizophrenia; CESC cis rs3540 0.512 rs3930162 chr15:91075129 C/T cg10434728 chr15:90938212 IQGAP1 -0.38 -6.71 -0.38 1.18e-10 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg20476274 chr7:133979776 SLC35B4 0.68 9.88 0.52 8.59e-20 Mean platelet volume; CESC cis rs6681460 0.866 rs1856318 chr1:67024215 T/C cg02459107 chr1:67143332 SGIP1 0.38 5.13 0.3 5.55e-7 Presence of antiphospholipid antibodies; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15461550 chr8:4644719 CSMD1 -0.51 -6.36 -0.36 8.69e-10 Gut microbiome composition (summer); CESC cis rs9796 0.870 rs2925345 chr15:41311799 T/C cg18705301 chr15:41695430 NDUFAF1 0.4 5.94 0.34 8.72e-9 Menopause (age at onset); CESC cis rs1198872 0.526 rs57282335 chr2:10928207 G/A cg25617230 chr2:10952979 PDIA6 0.44 5.12 0.3 5.83e-7 Cardiac Troponin-T levels; CESC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg26818010 chr10:134567672 INPP5A -0.94 -11.42 -0.57 7.62e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs939658 0.805 rs35832166 chr15:79417994 G/T cg17916960 chr15:79447300 NA -0.37 -6.08 -0.35 4.15e-9 Refractive error; CESC cis rs854765 0.583 rs4534911 chr17:17852330 A/G cg16928487 chr17:17741425 SREBF1 -0.59 -9.86 -0.52 9.9e-20 Total body bone mineral density; CESC cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -9.2 -0.49 1.12e-17 Mean corpuscular volume; CESC cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg25517755 chr10:38738941 LOC399744 -0.48 -6.18 -0.35 2.4e-9 Extrinsic epigenetic age acceleration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02004021 chr12:95868393 METAP2 -0.47 -6.8 -0.39 7.13e-11 Gambling; CESC cis rs7301826 0.651 rs4759521 chr12:131297313 C/T cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC cis rs2860975 0.620 rs7087256 chr10:96795524 T/C cg09036531 chr10:96991505 NA -0.35 -5.06 -0.3 7.67e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs9611565 0.592 rs5751129 chr22:42015765 C/T cg03806693 chr22:41940476 POLR3H 0.86 10.37 0.54 2.26e-21 Vitiligo; CESC cis rs6963495 0.818 rs73190189 chr7:105164452 G/A cg13798780 chr7:105162888 PUS7 0.79 8.16 0.45 1.36e-14 Bipolar disorder (body mass index interaction); CESC cis rs1691799 0.867 rs1168316 chr12:66746239 A/G cg16791601 chr12:66731901 HELB -0.79 -14.55 -0.67 1.18e-35 White blood cell count (basophil); CESC cis rs12477438 0.798 rs10196680 chr2:99628617 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs2191566 0.576 rs396786 chr19:44494351 A/G cg20607764 chr19:44506953 ZNF230 0.44 5.16 0.3 4.82e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs28374715 0.681 rs11629979 chr15:41626579 A/G cg02330683 chr15:41787940 ITPKA 0.47 6.28 0.36 1.35e-9 Ulcerative colitis; CESC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.91e-10 Bipolar disorder; CESC cis rs7937682 0.632 rs57414412 chr11:111769431 G/A cg22437258 chr11:111473054 SIK2 -0.5 -5.53 -0.32 7.78e-8 Primary sclerosing cholangitis; CESC cis rs9512730 0.553 rs6491212 chr13:28049631 T/C cg04070771 chr13:27998621 GTF3A 0.45 5.14 0.3 5.37e-7 Schizophrenia; CESC cis rs6446731 0.593 rs7656026 chr4:3273625 G/C cg08886695 chr4:3369023 RGS12 -0.38 -5.51 -0.32 8.38e-8 Mean platelet volume; CESC cis rs2066819 1.000 rs808919 chr12:56647911 C/G cg26734620 chr12:56694298 CS -0.89 -9.02 -0.48 3.78e-17 Psoriasis vulgaris; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg23424268 chr15:41056053 GCHFR -0.57 -6.61 -0.38 2.09e-10 Gut microbiota (bacterial taxa); CESC cis rs34638657 0.732 rs11645372 chr16:82202136 C/T cg09439754 chr16:82129088 HSD17B2 -0.35 -6.12 -0.35 3.29e-9 Lung adenocarcinoma; CESC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg08859206 chr1:53392774 SCP2 -0.65 -8.93 -0.48 7.24e-17 Monocyte count; CESC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg10691866 chr7:65817282 TPST1 0.33 5.64 0.33 4.3e-8 Aortic root size; CESC trans rs884366 1.000 rs1006081 chr6:109625550 C/T cg04557294 chr14:70119254 KIAA0247 -0.43 -6.36 -0.36 8.93e-10 HDL cholesterol levels;HDL cholesterol; CESC cis rs6570726 0.935 rs413916 chr6:145831400 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.74 0.38 9.63e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.77 9.93 0.52 5.92e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs13064411 0.696 rs6773497 chr3:113186514 T/C cg18753928 chr3:113234510 CCDC52 -0.49 -5.87 -0.34 1.31e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs7937682 0.883 rs631490 chr11:111452040 G/C cg09085632 chr11:111637200 PPP2R1B -0.91 -13.83 -0.65 3.94e-33 Primary sclerosing cholangitis; CESC cis rs9888739 1.000 rs7190018 chr16:31301478 G/A cg15817542 chr16:31343056 ITGAM -0.41 -5.03 -0.3 9.14e-7 Systemic lupus erythematosus; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg07094533 chr2:233415452 TIGD1;EIF4E2 -0.47 -6.2 -0.36 2.18e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7824557 0.767 rs10104728 chr8:11171300 A/G cg21775007 chr8:11205619 TDH 0.46 6.59 0.38 2.35e-10 Retinal vascular caliber; CESC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.08 -0.4 1.27e-11 Total body bone mineral density; CESC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs362272 0.505 rs3129310 chr4:3301388 T/G cg08886695 chr4:3369023 RGS12 -0.41 -5.58 -0.32 5.79e-8 Serum sulfate level; CESC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg14393609 chr7:65229607 NA -0.52 -6.97 -0.39 2.45e-11 Aortic root size; CESC trans rs9325144 0.647 rs34311455 chr12:39060889 C/T cg23762105 chr12:34175262 ALG10 0.46 6.01 0.35 6.05e-9 Morning vs. evening chronotype; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09791812 chr7:44121910 POLM -0.55 -6.77 -0.38 8.37e-11 Ulcerative colitis; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg12703194 chr16:3086867 CCDC64B -0.39 -6.03 -0.35 5.62e-9 Breast cancer; CESC cis rs6696846 0.936 rs1042831 chr1:205043250 G/C cg00857998 chr1:205179979 DSTYK 0.55 7.11 0.4 1.1e-11 Red blood cell count; CESC cis rs3733585 0.648 rs7378305 chr4:9954893 C/T cg11266682 chr4:10021025 SLC2A9 -0.57 -10.89 -0.56 4.42e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg08888203 chr3:10149979 C3orf24 0.48 6.05 0.35 4.97e-9 Alzheimer's disease; CESC cis rs17253792 0.822 rs13379343 chr14:56050205 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.8 0.34 1.89e-8 Putamen volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21638374 chr5:147763491 FBXO38 -0.47 -6.38 -0.36 7.87e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs5769765 0.657 rs8136116 chr22:50256886 T/A cg02269571 chr22:50332266 NA 0.46 5.46 0.32 1.08e-7 Schizophrenia; CESC cis rs9913156 0.748 rs55959711 chr17:4562581 C/A cg19197139 chr17:4613644 ARRB2 0.92 10.46 0.54 1.18e-21 Lymphocyte counts; CESC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg04772025 chr11:68637568 NA 0.54 6.36 0.36 8.64e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs881375 0.631 rs10739577 chr9:123668854 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.83 0.39 5.66e-11 Rheumatoid arthritis; CESC cis rs2735413 0.875 rs8045975 chr16:78090187 C/G cg04733911 chr16:78082701 NA 0.53 8.82 0.48 1.53e-16 Systolic blood pressure (alcohol consumption interaction); CESC cis rs12541635 0.677 rs1496181 chr8:107027141 C/T cg10147462 chr8:107024639 NA 0.43 6.42 0.37 6.17e-10 Age of smoking initiation; CESC cis rs977987 0.835 rs4888379 chr16:75340231 A/T cg03315344 chr16:75512273 CHST6 0.41 5.95 0.34 8.43e-9 Dupuytren's disease; CESC trans rs11098499 0.739 rs10031033 chr4:120151452 C/T cg25214090 chr10:38739885 LOC399744 0.51 6.76 0.38 8.87e-11 Corneal astigmatism; CESC cis rs6089584 0.528 rs4925334 chr20:60626769 C/T cg06108461 chr20:60628389 TAF4 -0.61 -8.18 -0.45 1.16e-14 Body mass index; CESC cis rs933688 1.000 rs6866191 chr5:90746852 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.07 11.86 0.59 2.53e-26 Smoking behavior; CESC cis rs977987 0.815 rs1364078 chr16:75396881 T/C cg03315344 chr16:75512273 CHST6 0.39 5.64 0.33 4.44e-8 Dupuytren's disease; CESC cis rs9640161 0.789 rs1464753 chr7:150021350 G/C cg13722127 chr7:150037890 RARRES2 0.34 5.11 0.3 6.29e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs6867032 0.834 rs10043083 chr5:1995687 C/G cg26168224 chr5:2018326 NA -0.85 -14.02 -0.65 8.87e-34 Gut microbiome composition (winter); CESC cis rs7818382 0.967 rs7812465 chr8:96050557 C/T cg16049864 chr8:95962084 TP53INP1 0.55 9.28 0.5 6.29e-18 Alzheimer's disease (late onset); CESC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg11494091 chr17:61959527 GH2 0.73 12.58 0.61 8.77e-29 Prudent dietary pattern; CESC cis rs7953249 0.564 rs11065385 chr12:121423386 A/G cg25281562 chr12:121454272 C12orf43 -0.55 -6.95 -0.39 2.81e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs113835537 0.935 rs117480267 chr11:66398596 C/T cg24851651 chr11:66362959 CCS 0.63 5.74 0.33 2.59e-8 Airway imaging phenotypes; CESC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg00129232 chr17:37814104 STARD3 0.57 7.44 0.42 1.38e-12 Glomerular filtration rate (creatinine); CESC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.67 0.38 1.48e-10 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05561555 chr12:131648301 LOC116437 0.43 6.04 0.35 5.07e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02343648 chr10:102133165 C10orf75 -0.69 -8.27 -0.45 6.65e-15 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs10890375 chr1:46406581 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1814175 0.817 rs7932683 chr11:49983640 G/A cg03929089 chr4:120376271 NA -0.93 -16.32 -0.71 6.51e-42 Height; CESC cis rs863345 0.967 rs1418847 chr1:158484378 A/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.8 -0.34 1.9e-8 Pneumococcal bacteremia; CESC cis rs7762018 1.000 rs6942332 chr6:170131934 A/G cg05834625 chr6:170176447 C6orf70 0.62 7.35 0.41 2.51e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6570726 0.935 rs392014 chr6:145843691 A/C cg23711669 chr6:146136114 FBXO30 0.77 11.49 0.58 4.76e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs72781680 1.000 rs72781680 chr2:24238928 C/T cg08917208 chr2:24149416 ATAD2B 1.13 9.83 0.52 1.17e-19 Lymphocyte counts; CESC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg23978390 chr7:1156363 C7orf50 0.67 6.49 0.37 4.2e-10 Bronchopulmonary dysplasia; CESC cis rs17253792 0.822 rs78522049 chr14:56071203 A/C cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs7647973 0.626 rs1586827 chr3:49671224 T/C cg03060546 chr3:49711283 APEH 0.68 8.32 0.46 4.7e-15 Menarche (age at onset); CESC cis rs7662987 0.517 rs3018047 chr4:100014510 C/T cg12011299 chr4:100065546 ADH4 -0.59 -6.86 -0.39 4.93e-11 Smoking initiation; CESC cis rs62283056 0.512 rs4568307 chr4:6284965 A/G cg00701064 chr4:6280414 WFS1 0.67 9.53 0.51 1.09e-18 Cisplatin-induced ototoxicity; CESC cis rs7914558 0.899 rs7913682 chr10:104684392 T/A cg04362960 chr10:104952993 NT5C2 0.44 5.6 0.33 5.35e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg17211192 chr8:82754475 SNX16 0.7 8.28 0.45 6.1e-15 Diastolic blood pressure; CESC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg06074448 chr4:187884817 NA -0.36 -5.17 -0.3 4.63e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.546 rs13141117 chr4:98892798 G/A cg05340658 chr4:99064831 C4orf37 0.54 6.57 0.37 2.63e-10 Colonoscopy-negative controls vs population controls; CESC cis rs1451375 0.642 rs6963996 chr7:50559300 T/C cg14593290 chr7:50529359 DDC -0.5 -6.27 -0.36 1.47e-9 Malaria; CESC cis rs2522056 1.000 rs7730247 chr5:131781288 A/C cg24060327 chr5:131705240 SLC22A5 0.65 7.73 0.43 2.23e-13 Lymphocyte counts;Fibrinogen; CESC cis rs61996546 0.635 rs61998671 chr15:26853000 T/C cg14859324 chr15:26874363 GABRB3 -0.37 -5.06 -0.3 7.97e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16136840 chr5:95997740 CAST -0.45 -6.25 -0.36 1.61e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg07648498 chr16:89883185 FANCA 0.43 5.21 0.3 3.81e-7 Vitiligo; CESC cis rs8060686 0.641 rs12599880 chr16:68152035 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 4.92e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs848353 1.000 rs11768328 chr7:108596014 A/G cg03555276 chr13:113260139 NA 0.58 6.33 0.36 1.06e-9 Smoking behavior; CESC cis rs7527798 0.592 rs2296159 chr1:207851760 G/A cg09232269 chr1:207846808 CR1L -0.28 -5.14 -0.3 5.27e-7 Erythrocyte sedimentation rate; CESC cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 7.6 0.42 5.28e-13 Personality dimensions; CESC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg08888203 chr3:10149979 C3orf24 0.5 6.33 0.36 1.05e-9 Alzheimer's disease; CESC cis rs9837602 0.529 rs793495 chr3:99507934 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.48 5.97 0.34 7.58e-9 Breast cancer; CESC cis rs2625529 0.652 rs2957734 chr15:72261385 A/G cg16672083 chr15:72433130 SENP8 0.46 6.78 0.38 7.78e-11 Red blood cell count; CESC cis rs12079745 0.793 rs113426965 chr1:169406545 T/C cg09363564 chr1:169337483 NME7;BLZF1 -1.26 -7.33 -0.41 2.72e-12 QT interval; CESC cis rs5750830 0.594 rs6001568 chr22:39775786 G/A cg01416388 chr22:39784598 NA -0.6 -7.58 -0.42 5.87e-13 Intelligence (multi-trait analysis); CESC cis rs3749237 0.537 rs4459909 chr3:49469217 T/C cg02487422 chr3:49467188 NICN1 0.58 8.47 0.46 1.7e-15 Resting heart rate; CESC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg18404041 chr3:52824283 ITIH1 -0.46 -7.72 -0.43 2.45e-13 Bipolar disorder; CESC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg08968635 chr6:28129556 ZNF389 -0.36 -5.06 -0.3 7.72e-7 Depression; CESC cis rs2204008 0.837 rs2387317 chr12:38235319 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.52 1.51e-19 Bladder cancer; CESC cis rs2832191 0.791 rs2251517 chr21:30531951 T/G cg24692254 chr21:30365293 RNF160 0.89 14.56 0.67 1.13e-35 Dental caries; CESC cis rs7208859 0.623 rs9890558 chr17:29110355 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01806965 chr8:144378397 ZNF696 0.53 6.92 0.39 3.49e-11 Fibrinogen levels; CESC cis rs9287719 0.967 rs4669596 chr2:10720572 C/T cg00105475 chr2:10696890 NA 0.39 5.75 0.33 2.43e-8 Prostate cancer; CESC cis rs7267979 1.000 rs2258066 chr20:25271326 C/T cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.13e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs8073060 0.586 rs225265 chr17:33961972 C/T cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs2742234 0.910 rs2503866 chr10:43646261 T/A cg07801480 chr10:43725741 RASGEF1A 0.39 5.64 0.33 4.27e-8 Hirschsprung disease; CESC cis rs454510 0.826 rs347903 chr1:120192431 C/T cg11530693 chr1:120165357 ZNF697 0.44 5.67 0.33 3.67e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg18758796 chr5:131593413 PDLIM4 0.39 5.21 0.3 3.84e-7 Acylcarnitine levels; CESC cis rs35110281 0.720 rs162400 chr21:44950305 A/C cg21573476 chr21:45109991 RRP1B -0.42 -5.79 -0.34 2.01e-8 Mean corpuscular volume; CESC cis rs12579753 0.827 rs7958100 chr12:82200782 G/A cg24719984 chr12:82153464 PPFIA2 -0.34 -5.08 -0.3 7.15e-7 Resting heart rate; CESC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 5.31 0.31 2.37e-7 Height; CESC cis rs7845219 0.506 rs12548999 chr8:95929843 C/T cg13393036 chr8:95962371 TP53INP1 -0.4 -7.56 -0.42 6.54e-13 Type 2 diabetes; CESC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg11764359 chr7:65958608 NA 0.78 11.31 0.57 1.86e-24 Aortic root size; CESC cis rs61931739 0.500 rs3924705 chr12:34557825 A/T cg06521331 chr12:34319734 NA -0.36 -5.03 -0.3 9.01e-7 Morning vs. evening chronotype; CESC cis rs9623117 0.874 rs6519216 chr22:40472399 G/A cg05033341 chr22:40419857 FAM83F -0.46 -5.2 -0.3 4.05e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs4794106 0.792 rs11365 chr17:48211533 T/G cg13127421 chr17:48202128 SAMD14 -0.53 -7.68 -0.43 3e-13 Temporomandibular joint disorder; CESC cis rs8017423 0.967 rs17188605 chr14:90722579 C/T cg14092571 chr14:90743983 NA -0.55 -8.31 -0.45 5.06e-15 Mortality in heart failure; CESC cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.87 0.34 1.33e-8 Tonsillectomy; CESC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg05872129 chr22:39784769 NA -0.82 -10.84 -0.55 6.5e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg18904891 chr8:8559673 CLDN23 0.73 8.46 0.46 1.83e-15 Obesity-related traits; CESC cis rs892961 1.000 rs11077907 chr17:75400706 G/A cg05865280 chr17:75406074 SEPT9 0.57 10.08 0.53 1.92e-20 Airflow obstruction; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02374837 chr16:8891602 PMM2;TMEM186 -0.49 -6.75 -0.38 9.4e-11 Gambling; CESC cis rs9649465 0.967 rs13244694 chr7:123329879 T/C cg04330084 chr7:123175371 IQUB -0.38 -5.22 -0.31 3.69e-7 Migraine; CESC cis rs939574 1.000 rs2071385 chr2:220118782 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.8 6.86 0.39 4.9e-11 Platelet distribution width; CESC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg17143192 chr8:8559678 CLDN23 0.71 7.92 0.44 6.78e-14 Obesity-related traits; CESC cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg06697600 chr4:7070879 GRPEL1 -0.47 -6.85 -0.39 5.02e-11 Monocyte percentage of white cells; CESC trans rs11039798 0.545 rs7118670 chr11:48532056 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.68 0.38 1.4e-10 Axial length; CESC trans rs6964833 0.786 rs35633336 chr7:74058292 G/T cg07504079 chr7:72649617 NCF1B -0.54 -6.15 -0.35 2.87e-9 Menarche (age at onset); CESC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.25 0.45 7.5e-15 Menopause (age at onset); CESC cis rs77633900 0.892 rs2469216 chr15:76613477 C/T cg09663584 chr15:77347405 TSPAN3 0.58 5.1 0.3 6.39e-7 Non-glioblastoma glioma;Glioma; CESC cis rs4820539 0.966 rs5759600 chr22:23483769 C/A cg14186256 chr22:23484241 RTDR1 0.83 14.76 0.67 2.18e-36 Bone mineral density; CESC cis rs9811920 0.638 rs2452321 chr3:99638836 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.57 7.02 0.4 1.84e-11 Axial length; CESC cis rs910316 0.967 rs4903285 chr14:75609268 A/T cg08847533 chr14:75593920 NEK9 1.03 20.54 0.78 9.98e-57 Height; CESC cis rs6546550 0.901 rs6739780 chr2:70138111 G/A cg02498382 chr2:70120550 SNRNP27 -0.4 -7.03 -0.4 1.71e-11 Prevalent atrial fibrillation; CESC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg18876405 chr7:65276391 NA 0.7 9.83 0.52 1.18e-19 Aortic root size; CESC cis rs7712401 0.601 rs27976 chr5:122206460 C/T cg19412675 chr5:122181750 SNX24 -0.41 -5.04 -0.3 8.57e-7 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05859395 chr5:203595 NA 0.47 6.17 0.35 2.48e-9 Fibrinogen levels; CESC cis rs3091242 0.933 rs35530120 chr1:25785451 A/G cg27572855 chr1:25598939 RHD -0.43 -7.13 -0.4 9.46e-12 Erythrocyte sedimentation rate; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg09378111 chr2:211036309 C2orf67 0.48 6.08 0.35 4.08e-9 Tetralogy of Fallot; CESC cis rs3126085 0.935 rs11588174 chr1:152175970 C/T cg03465714 chr1:152285911 FLG 0.46 5.67 0.33 3.77e-8 Atopic dermatitis; CESC cis rs1185460 0.967 rs1786690 chr11:118942067 A/G cg01677386 chr11:118938358 VPS11 -0.45 -5.52 -0.32 8.16e-8 Coronary artery disease; CESC cis rs17401966 0.931 rs12409754 chr1:10457540 T/C cg15208524 chr1:10270712 KIF1B 0.42 5.25 0.31 3.09e-7 Hepatocellular carcinoma; CESC cis rs718433 0.584 rs10133988 chr14:22214659 A/C cg02257791 chr14:22217085 NA -0.32 -5.09 -0.3 6.83e-7 Intraocular pressure; CESC cis rs17376456 0.877 rs7728736 chr5:93404277 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.23 0.31 3.49e-7 Diabetic retinopathy; CESC cis rs12586317 0.620 rs7147571 chr14:35530236 T/C cg16230307 chr14:35515116 FAM177A1 0.93 9.86 0.52 9.69e-20 Psoriasis; CESC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.23 0.31 3.4e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15013526 chr3:170588137 RPL22L1 0.62 7.2 0.4 6.21e-12 Gut microbiome composition (summer); CESC cis rs60843830 0.661 rs11674477 chr2:105822 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.5 6.01 0.35 6.07e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs116095464 0.558 rs6866776 chr5:264495 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.86e-15 Breast cancer; CESC cis rs4253772 0.591 rs6008545 chr22:46686375 C/T cg09491104 chr22:46646882 C22orf40 -0.55 -7.58 -0.42 5.65e-13 LDL cholesterol;Cholesterol, total; CESC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg06582575 chr6:163149167 PACRG;PARK2 1.02 10.3 0.53 3.86e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9346455 0.614 rs2208845 chr6:71997278 T/C cg27238071 chr6:71998145 OGFRL1 0.6 5.93 0.34 9.65e-9 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs11608355 0.521 rs4766469 chr12:109836890 C/G cg19025524 chr12:109796872 NA 0.52 7.36 0.41 2.32e-12 Neuroticism; CESC cis rs1707322 0.752 rs28568986 chr1:46207743 C/T cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18512092 chr2:27274554 AGBL5 -0.4 -6.05 -0.35 4.87e-9 Gambling; CESC cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.706 rs1054488 chr17:37687968 A/G cg00129232 chr17:37814104 STARD3 -0.55 -5.69 -0.33 3.39e-8 Glomerular filtration rate (creatinine); CESC cis rs7833986 0.501 rs72651502 chr8:56875533 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.55 6.75 0.38 9.26e-11 Height; CESC cis rs7267979 1.000 rs6083809 chr20:25329309 A/G cg08601574 chr20:25228251 PYGB -0.38 -5.51 -0.32 8.54e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs6963495 0.818 rs117887993 chr7:105193837 T/G cg13798780 chr7:105162888 PUS7 0.77 7.64 0.42 4.08e-13 Bipolar disorder (body mass index interaction); CESC cis rs8070740 1.000 rs8076900 chr17:5327927 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.52 6.29 0.36 1.34e-9 Menopause (age at onset); CESC trans rs12912184 0.633 rs2079596 chr15:92752148 G/A cg17173639 chr6:162384350 PARK2 -0.59 -6.14 -0.35 2.97e-9 Smoking initiation; CESC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg19468946 chr17:37922297 IKZF3 0.41 5.57 0.32 6.39e-8 Self-reported allergy; CESC cis rs7116495 0.609 rs1541304 chr11:71714078 T/C cg07596299 chr11:71824057 C11orf51 -0.82 -5.33 -0.31 2.13e-7 Severe influenza A (H1N1) infection; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01185801 chr11:65265397 MALAT1 -0.45 -6.03 -0.35 5.35e-9 Height; CESC cis rs17818399 0.547 rs35178974 chr2:46763898 T/C cg06386533 chr2:46925753 SOCS5 0.46 5.05 0.3 8.27e-7 Height; CESC cis rs7666738 0.830 rs1593573 chr4:98925293 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs992157 0.560 rs10932763 chr2:219085863 G/C cg20019365 chr2:219134978 PNKD;AAMP -0.57 -7.45 -0.42 1.29e-12 Colorectal cancer; CESC trans rs7448080 0.510 rs1604403 chr5:123259166 T/G cg10971134 chr1:56877429 NA 0.93 6.27 0.36 1.5e-9 Alcohol dependence (age at onset); CESC cis rs8114671 0.967 rs3746427 chr20:33730464 A/G cg06115741 chr20:33292138 TP53INP2 0.42 5.14 0.3 5.44e-7 Height; CESC cis rs1983891 0.742 rs4711677 chr6:41555862 G/A cg20194872 chr6:41519635 FOXP4 0.48 6.75 0.38 9.41e-11 Prostate cancer; CESC cis rs4664308 0.870 rs2305818 chr2:161029218 G/A cg03641300 chr2:160917029 PLA2R1 -0.61 -8.95 -0.48 6.4e-17 Idiopathic membranous nephropathy; CESC cis rs4930561 0.765 rs34493482 chr11:67969508 T/C cg16338278 chr11:67432957 ALDH3B2 0.42 5.27 0.31 2.77e-7 Breast cancer in childhood cancer survivors;IgG glycosylation; CESC cis rs7809950 0.817 rs4727679 chr7:107085018 T/C cg23024343 chr7:107201750 COG5 -0.56 -7.2 -0.4 6.06e-12 Coronary artery disease; CESC cis rs17433780 0.857 rs12144445 chr1:89465238 C/T cg09516651 chr1:89888402 LOC400759 0.67 9.0 0.48 4.53e-17 Carotid intima media thickness; CESC cis rs7116495 0.609 rs11235444 chr11:71831859 G/A cg18441811 chr11:71824068 C11orf51 0.84 5.35 0.31 1.93e-7 Severe influenza A (H1N1) infection; CESC cis rs9818758 0.607 rs113186424 chr3:49272726 T/C cg00383909 chr3:49044727 WDR6 0.81 6.24 0.36 1.74e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs72829446 0.530 rs4796430 chr17:7401903 A/G cg02795151 chr17:7402630 POLR2A 0.62 6.59 0.38 2.34e-10 Androgen levels; CESC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg04315214 chr1:2043799 PRKCZ 0.47 7.66 0.43 3.6e-13 Height; CESC cis rs2839186 0.872 rs13052495 chr21:47707474 G/A cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 7.02e-11 Testicular germ cell tumor; CESC cis rs6963495 0.818 rs73190158 chr7:105153943 T/C cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs2228479 0.850 rs62054638 chr16:89821131 G/C cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs2070488 0.804 rs13063978 chr3:38476538 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 13.18 0.63 7.62e-31 Electrocardiographic conduction measures; CESC cis rs8044868 0.586 rs6499557 chr16:72082654 A/G cg01557791 chr16:72042693 DHODH -0.43 -5.89 -0.34 1.17e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.67 -0.33 3.76e-8 Aortic root size; CESC trans rs4950322 0.580 rs17359629 chr1:146593119 C/T cg04954894 chr8:38089920 DDHD2 -0.6 -6.69 -0.38 1.3e-10 Protein quantitative trait loci; CESC cis rs66573146 0.572 rs66611116 chr4:6953270 A/G cg26116260 chr4:7069785 GRPEL1 -0.8 -5.33 -0.31 2.08e-7 Granulocyte percentage of myeloid white cells; CESC cis rs8082590 1 rs8082590 chr17:17958402 G/A cg04398451 chr17:18023971 MYO15A 0.72 10.46 0.54 1.15e-21 Schizophrenia; CESC cis rs12586317 0.620 rs17091786 chr14:35565856 A/T cg16230307 chr14:35515116 FAM177A1 0.95 10.08 0.53 1.9e-20 Psoriasis; CESC trans rs7615952 0.512 rs1077621 chr3:125819799 A/G cg07211511 chr3:129823064 LOC729375 -0.57 -6.28 -0.36 1.38e-9 Blood pressure (smoking interaction); CESC trans rs1814175 0.645 rs1851844 chr11:50021773 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -6.13 -0.35 3.1e-9 Height; CESC cis rs35520189 0.845 rs12479173 chr2:113649210 G/A cg06156847 chr2:113672199 IL1F7 0.37 5.62 0.33 4.77e-8 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg05283184 chr6:79620031 NA -0.43 -6.55 -0.37 2.95e-10 Intelligence (multi-trait analysis); CESC cis rs12477438 0.765 rs7340412 chr2:99661148 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs6088590 1.000 rs3787222 chr20:33333040 T/A cg06115741 chr20:33292138 TP53INP2 0.6 7.34 0.41 2.7e-12 Coronary artery disease; CESC cis rs57221529 0.766 rs72706608 chr5:559203 C/T cg16447950 chr5:562315 NA -0.7 -7.76 -0.43 1.9e-13 Lung disease severity in cystic fibrosis; CESC cis rs4268898 0.931 rs7603997 chr2:24524958 C/T cg08917208 chr2:24149416 ATAD2B 0.47 5.37 0.31 1.73e-7 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26101466 chr14:64108700 WDR89 0.54 6.42 0.37 6.29e-10 Gut microbiome composition (summer); CESC cis rs7927771 0.524 rs10838771 chr11:47831332 A/G cg20307385 chr11:47447363 PSMC3 -0.58 -7.99 -0.44 4.29e-14 Subjective well-being; CESC cis rs10191773 0.589 rs72831639 chr2:112949291 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.7 -6.53 -0.37 3.41e-10 Yeast infection; CESC cis rs6831352 0.918 rs13113166 chr4:100050528 A/G cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs11122272 0.735 rs971534 chr1:231521971 C/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs12930096 1.000 rs55947021 chr16:11678949 C/A cg07439791 chr16:11680400 LITAF 0.61 5.66 0.33 3.84e-8 QT interval; CESC cis rs1559088 0.948 rs12610071 chr19:33582687 A/C cg17764715 chr19:33622953 WDR88 0.5 6.46 0.37 4.9e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2247341 0.894 rs2592831 chr4:1711404 T/C cg07465881 chr4:1713556 SLBP -0.53 -6.64 -0.38 1.73e-10 Hip circumference adjusted for BMI;Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22119665 chr22:23745131 ZDHHC8P 0.41 6.33 0.36 1.04e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs965469 0.947 rs6139087 chr20:3329062 T/C cg25506879 chr20:3388711 C20orf194 -0.54 -5.78 -0.33 2.14e-8 IFN-related cytopenia; CESC cis rs1559088 0.895 rs7259582 chr19:33593979 A/G cg27124370 chr19:33622961 WDR88 0.45 6.0 0.35 6.49e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4523957 0.890 rs9895551 chr17:2115922 C/G cg16513277 chr17:2031491 SMG6 0.64 8.95 0.48 6.57e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg22875332 chr1:76189707 ACADM 0.76 11.73 0.58 7.41e-26 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.91 -0.52 6.75e-20 Developmental language disorder (linguistic errors); CESC cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg16339924 chr4:17578868 LAP3 0.65 8.27 0.45 6.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9309473 0.948 rs13392691 chr2:73748980 G/A cg20560298 chr2:73613845 ALMS1 -0.54 -6.84 -0.39 5.52e-11 Metabolite levels; CESC cis rs7674212 0.541 rs2615539 chr4:104081106 C/G cg16532752 chr4:104119610 CENPE -0.45 -6.18 -0.36 2.37e-9 Type 2 diabetes; CESC cis rs6748734 1.000 rs6724662 chr2:241831560 A/G cg04034577 chr2:241836375 C2orf54 -0.48 -8.04 -0.44 2.98e-14 Urinary metabolites; CESC cis rs7267979 0.816 rs6076358 chr20:25519403 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.77 -14.19 -0.66 2.27e-34 Liver enzyme levels (alkaline phosphatase); CESC trans rs561341 0.769 rs559228 chr17:30294527 T/C cg20587970 chr11:113659929 NA -1.43 -18.65 -0.75 3.85e-50 Hip circumference adjusted for BMI; CESC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg13206674 chr6:150067644 NUP43 0.43 6.23 0.36 1.82e-9 Lung cancer; CESC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg25036284 chr2:26402008 FAM59B -0.71 -8.23 -0.45 8.41e-15 Gut microbiome composition (summer); CESC cis rs6496667 0.632 rs6496658 chr15:90884105 A/G cg22089800 chr15:90895588 ZNF774 0.49 5.92 0.34 9.75e-9 Rheumatoid arthritis; CESC cis rs2708240 0.666 rs2710104 chr7:147592649 A/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.37 -6.16 -0.35 2.71e-9 QT interval (drug interaction); CESC cis rs11792861 0.926 rs2271878 chr9:111868885 G/A cg13535736 chr9:111863775 C9orf5 -0.5 -6.66 -0.38 1.6e-10 Menarche (age at onset); CESC cis rs6952809 0.532 rs7803015 chr7:2432143 G/A cg23289794 chr7:2394357 EIF3B -0.66 -6.57 -0.37 2.72e-10 Multiple sclerosis; CESC trans rs875971 1.000 rs11974219 chr7:65647410 C/T cg26939375 chr7:64535504 NA -0.48 -6.31 -0.36 1.17e-9 Aortic root size; CESC cis rs9911578 0.967 rs2429369 chr17:56501420 A/G cg05425664 chr17:57184151 TRIM37 -0.48 -6.79 -0.38 7.4e-11 Intelligence (multi-trait analysis); CESC cis rs35306767 0.953 rs12357633 chr10:957246 C/T cg20503657 chr10:835505 NA 0.9 9.27 0.49 6.58e-18 Eosinophil percentage of granulocytes; CESC cis rs11785693 0.862 rs11780705 chr8:4988221 G/A cg26367366 chr8:4980734 NA 0.93 8.78 0.47 2.12e-16 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs4919044 0.688 rs59539045 chr10:94776594 C/A cg00487187 chr10:94451625 HHEX -0.45 -5.05 -0.3 8.21e-7 Coronary artery disease; CESC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg18758796 chr5:131593413 PDLIM4 0.45 6.41 0.37 6.79e-10 Breast cancer; CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg15147215 chr3:52552868 STAB1 -0.39 -7.1 -0.4 1.15e-11 Electroencephalogram traits; CESC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.44 -0.37 5.7e-10 Depression; CESC cis rs3008870 1.000 rs2815361 chr1:67494591 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.98 13.07 0.63 1.83e-30 Lymphocyte percentage of white cells; CESC cis rs9811920 0.838 rs12488245 chr3:99835254 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.43 6.86 0.39 4.97e-11 Axial length; CESC cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg25019033 chr10:957182 NA -0.57 -6.07 -0.35 4.31e-9 Eosinophil percentage of granulocytes; CESC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs4975616 0.839 rs2447853 chr5:1333077 A/G cg26373071 chr5:1325741 CLPTM1L 0.43 6.76 0.38 8.72e-11 Lung cancer; CESC trans rs7246760 1.000 rs59771283 chr19:9854958 G/A cg02900749 chr2:68251473 NA -0.84 -7.32 -0.41 2.99e-12 Pursuit maintenance gain; CESC cis rs7713065 0.765 rs28655019 chr5:131770881 C/A cg10809880 chr5:131517096 NA -0.46 -5.2 -0.3 3.92e-7 Lung function (FEV1/FVC); CESC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg10691866 chr7:65817282 TPST1 0.35 5.82 0.34 1.66e-8 Aortic root size; CESC cis rs3733585 0.673 rs4455410 chr4:9953297 C/T cg02734326 chr4:10020555 SLC2A9 0.39 5.45 0.32 1.17e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg20151795 chr6:28129481 ZNF389 0.41 5.28 0.31 2.69e-7 Depression; CESC cis rs61776719 0.520 rs17465651 chr1:38418496 C/T cg26398791 chr1:38455867 SF3A3 -0.44 -5.64 -0.33 4.46e-8 Coronary artery disease; CESC cis rs919433 0.750 rs788010 chr2:198230949 T/C cg10820045 chr2:198174542 NA 0.41 5.93 0.34 9.6e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9549260 0.755 rs2721069 chr13:41143720 C/T cg21288729 chr13:41239152 FOXO1 0.66 8.4 0.46 2.69e-15 Red blood cell count; CESC cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg06212747 chr3:49208901 KLHDC8B 0.66 8.74 0.47 2.71e-16 Parkinson's disease; CESC cis rs6570726 0.846 rs426874 chr6:145880630 A/C cg23711669 chr6:146136114 FBXO30 0.87 12.84 0.62 1.13e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs4319547 0.915 rs11058402 chr12:122981053 A/G cg05707623 chr12:122985044 ZCCHC8 -0.66 -7.6 -0.42 5.09e-13 Body mass index; CESC cis rs9308433 0.505 rs6695148 chr1:214497861 G/T cg06198575 chr1:214491504 SMYD2 0.49 5.98 0.34 7.22e-9 IgG glycosylation; CESC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg10295955 chr4:187884368 NA -1.05 -18.46 -0.75 1.69e-49 Lobe attachment (rater-scored or self-reported); CESC cis rs4234284 0.556 rs13072737 chr3:126948835 C/T cg27326032 chr3:127006922 NA -0.42 -5.71 -0.33 2.95e-8 Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel); CESC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg24209194 chr3:40518798 ZNF619 0.49 6.15 0.35 2.83e-9 Renal cell carcinoma; CESC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.48 -6.18 -0.35 2.39e-9 Tonsillectomy; CESC cis rs1153858 0.945 rs7182300 chr15:45634928 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg14393609 chr7:65229607 NA -0.41 -5.77 -0.33 2.21e-8 Aortic root size; CESC cis rs73206853 0.925 rs12310834 chr12:110762756 A/G cg12870014 chr12:110450643 ANKRD13A 0.63 5.96 0.34 7.9e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs11608355 0.521 rs9888353 chr12:109843594 G/A cg19025524 chr12:109796872 NA -0.53 -7.28 -0.41 3.84e-12 Neuroticism; CESC cis rs17433780 0.928 rs12127787 chr1:89458761 T/C cg09516651 chr1:89888402 LOC400759 0.67 9.09 0.49 2.48e-17 Carotid intima media thickness; CESC trans rs1038903 0.893 rs6448593 chr4:28757802 A/G cg15651925 chr7:156259219 NA 0.48 6.11 0.35 3.51e-9 Menarche (age at onset); CESC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg16325326 chr1:53192061 ZYG11B -0.9 -15.35 -0.69 1.7e-38 Monocyte count; CESC cis rs7143963 0.666 rs8017944 chr14:103320048 T/G cg24154132 chr14:103367632 TRAF3 0.37 6.59 0.38 2.35e-10 Body mass index; CESC cis rs2228479 0.681 rs62052184 chr16:89967217 T/C cg04013166 chr16:89971882 TCF25 0.71 8.29 0.45 5.65e-15 Skin colour saturation; CESC cis rs10927875 0.597 rs61782184 chr1:16150976 G/A cg21385522 chr1:16154831 NA -1.01 -16.01 -0.7 8.12e-41 Dilated cardiomyopathy; CESC cis rs9682041 0.740 rs6444929 chr3:170150076 C/T cg11886554 chr3:170076028 SKIL 0.68 5.59 0.32 5.54e-8 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs736801 0.504 rs2070721 chr5:131825842 T/G cg21138405 chr5:131827807 IRF1 0.38 6.42 0.37 6.3e-10 Breast cancer;Mosquito bite size; CESC cis rs57506017 0.585 rs7785189 chr7:12257527 C/T cg23422036 chr7:12250390 TMEM106B 0.38 5.11 0.3 6.06e-7 Neuroticism; CESC cis rs5758511 0.679 rs55867855 chr22:42623258 G/A cg00645731 chr22:42541494 CYP2D7P1 0.58 8.64 0.47 5.58e-16 Birth weight; CESC cis rs739401 0.572 rs739400 chr11:3016520 G/A cg08508325 chr11:3079039 CARS -0.54 -10.37 -0.54 2.27e-21 Longevity; CESC cis rs8017423 0.935 rs8012299 chr14:90715822 G/T cg14092571 chr14:90743983 NA -0.58 -8.8 -0.48 1.84e-16 Mortality in heart failure; CESC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg00750074 chr16:89608354 SPG7 -0.41 -6.02 -0.35 5.87e-9 Multiple myeloma (IgH translocation); CESC cis rs568617 0.953 rs645900 chr11:65648135 G/A cg00576331 chr11:65640516 EFEMP2 0.45 5.3 0.31 2.48e-7 Crohn's disease; CESC cis rs1005277 0.579 rs1780116 chr10:38526621 C/T cg00409905 chr10:38381863 ZNF37A -0.51 -6.77 -0.38 8.46e-11 Extrinsic epigenetic age acceleration; CESC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg12963246 chr6:28129442 ZNF389 0.58 7.55 0.42 7e-13 Depression; CESC cis rs9486719 1.000 rs4078038 chr6:96904366 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -8.08 -0.44 2.23e-14 Migraine;Coronary artery disease; CESC cis rs116095464 0.558 rs12173244 chr5:269524 G/A cg22496380 chr5:211416 CCDC127 -0.75 -8.61 -0.47 6.58e-16 Breast cancer; CESC cis rs1008375 1.000 rs12648232 chr4:17612537 C/T cg16339924 chr4:17578868 LAP3 -0.57 -7.2 -0.4 6.14e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3741798 1.000 rs118108016 chr12:12482820 C/A cg08615371 chr12:12503544 MANSC1 0.85 5.98 0.34 7.16e-9 Cerebrospinal fluid biomarker levels; CESC cis rs8114671 0.839 rs2104084 chr20:33649217 G/C cg24642439 chr20:33292090 TP53INP2 -0.47 -5.71 -0.33 3.09e-8 Height; CESC cis rs1707322 0.721 rs28501477 chr1:46199084 A/G cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4975616 0.686 rs37008 chr5:1351538 C/T cg07493874 chr5:1342172 CLPTM1L -0.41 -7.98 -0.44 4.52e-14 Lung cancer; CESC cis rs9814567 0.712 rs4955545 chr3:134332926 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.12 -0.3 5.84e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6963495 0.745 rs73190169 chr7:105160500 A/G cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.5 0.46 1.42e-15 Bipolar disorder; CESC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg14709524 chr16:89940631 TCF25 0.89 6.55 0.37 2.99e-10 Skin colour saturation; CESC cis rs8077889 0.719 rs2079006 chr17:41865745 C/G cg26893861 chr17:41843967 DUSP3 0.98 17.65 0.74 1.24e-46 Triglycerides; CESC cis rs9916302 0.752 rs6503513 chr17:37561613 A/G cg07936489 chr17:37558343 FBXL20 0.98 13.6 0.64 2.6e-32 Glomerular filtration rate (creatinine); CESC cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.33 0.54 2.98e-21 Monocyte percentage of white cells; CESC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg18876405 chr7:65276391 NA 0.47 6.15 0.35 2.9e-9 Aortic root size; CESC cis rs4704187 0.687 rs1422698 chr5:74443132 C/T cg03227963 chr5:74354835 NA 0.3 5.52 0.32 8.21e-8 Response to amphetamines; CESC cis rs742614 0.533 rs2626547 chr20:32404921 G/A cg06304546 chr20:32448765 NA -0.41 -5.24 -0.31 3.28e-7 Stearic acid (18:0) levels; CESC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg19622623 chr12:86230825 RASSF9 -0.45 -5.42 -0.32 1.31e-7 Major depressive disorder; CESC cis rs77741769 0.571 rs7969140 chr12:121303626 T/C cg02419362 chr12:121203948 SPPL3 0.34 5.59 0.32 5.6e-8 Mean corpuscular volume; CESC cis rs3820068 0.603 rs16851884 chr1:15961871 A/G cg17385448 chr1:15911702 AGMAT 0.42 6.89 0.39 4.06e-11 Systolic blood pressure; CESC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg15145296 chr3:125709740 NA -0.56 -5.97 -0.34 7.65e-9 Blood pressure (smoking interaction); CESC cis rs7666738 0.830 rs991169 chr4:98928567 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg08564027 chr20:61660810 NA 0.9 15.37 0.69 1.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.52 -7.27 -0.41 4.01e-12 Menopause (age at onset); CESC cis rs1018836 0.923 rs7812970 chr8:91541229 G/A cg16814680 chr8:91681699 NA -0.71 -10.57 -0.54 4.94e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1048238 0.506 rs598371 chr1:16212739 G/A cg21385522 chr1:16154831 NA -0.43 -5.32 -0.31 2.18e-7 Systolic blood pressure; CESC cis rs9303280 0.742 rs11557466 chr17:38024626 C/T cg20243544 chr17:37824526 PNMT 0.53 6.92 0.39 3.47e-11 Self-reported allergy; CESC cis rs897080 0.552 rs1067323 chr2:44630018 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs7264396 1.000 rs224436 chr20:34154124 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.04 -0.35 5.27e-9 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09247534 chr1:172502038 C1orf9 0.53 6.06 0.35 4.72e-9 Gut microbiome composition (summer); CESC cis rs6906287 0.625 rs7764272 chr6:118692498 A/C cg21191810 chr6:118973309 C6orf204 0.31 5.04 0.3 8.62e-7 Electrocardiographic conduction measures; CESC cis rs926392 0.589 rs6093115 chr20:37693817 T/C cg16355469 chr20:37678765 NA 0.46 5.16 0.3 4.75e-7 Dialysis-related mortality; CESC cis rs477692 0.673 rs1078847 chr10:131352115 T/C cg24747557 chr10:131355152 MGMT -0.38 -5.22 -0.31 3.59e-7 Response to temozolomide; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg00021576 chr1:244211966 NA 0.46 6.32 0.36 1.12e-9 Post-traumatic stress disorder; CESC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg03240473 chr21:43526662 UMODL1;C21orf128 -0.52 -7.04 -0.4 1.64e-11 IgG glycosylation; CESC cis rs7100689 0.753 rs1361458 chr10:82090339 A/T cg00277334 chr10:82204260 NA -0.59 -7.48 -0.42 1.11e-12 Post bronchodilator FEV1; CESC cis rs6665290 0.935 rs6704144 chr1:227201030 C/G cg10327440 chr1:227177885 CDC42BPA -1.08 -22.77 -0.81 2.5e-64 Myeloid white cell count; CESC cis rs854765 0.693 rs8080061 chr17:17776389 C/T cg09796270 chr17:17721594 SREBF1 -0.42 -6.0 -0.35 6.4e-9 Total body bone mineral density; CESC cis rs3008870 1.000 rs11208976 chr1:67434411 A/G cg02640540 chr1:67518911 SLC35D1 -0.51 -5.58 -0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs12681288 0.676 rs1562921 chr8:1021986 G/T cg04851639 chr8:1020857 NA -0.38 -8.41 -0.46 2.5e-15 Schizophrenia; CESC cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg26597838 chr10:835615 NA 0.86 8.92 0.48 8.09e-17 Eosinophil percentage of granulocytes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10692753 chr16:23464628 COG7 -0.44 -6.15 -0.35 2.87e-9 Asthma; CESC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg12463550 chr7:65579703 CRCP 0.49 6.35 0.36 9.51e-10 Aortic root size; CESC cis rs2072732 0.904 rs9660819 chr1:2952823 C/T cg15211996 chr1:2936768 ACTRT2 0.34 5.95 0.34 8.31e-9 Plateletcrit; CESC cis rs2777491 0.915 rs7165675 chr15:41614704 T/C cg02330683 chr15:41787940 ITPKA 0.45 6.56 0.37 2.73e-10 Ulcerative colitis; CESC cis rs1950626 0.833 rs67456801 chr14:101399169 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.8 10.74 0.55 1.4e-22 Pelvic organ prolapse (moderate/severe); CESC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg04025307 chr7:1156635 C7orf50 0.38 5.89 0.34 1.16e-8 Longevity;Endometriosis; CESC cis rs2795502 1.000 rs2795496 chr10:43337842 G/A cg27426351 chr10:43362370 NA -0.44 -5.45 -0.32 1.17e-7 Blood protein levels; CESC cis rs9611565 0.546 rs5758426 chr22:42098763 T/G cg03806693 chr22:41940476 POLR3H 0.79 9.48 0.5 1.49e-18 Vitiligo; CESC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg07677032 chr17:61819896 STRADA 0.46 6.21 0.36 2.06e-9 Prudent dietary pattern; CESC cis rs7264396 0.563 rs2425100 chr20:34310115 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.75 0.38 9.35e-11 Total cholesterol levels; CESC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg27165867 chr14:105738592 BRF1 0.55 6.33 0.36 1.02e-9 Mean platelet volume;Platelet distribution width; CESC cis rs8067354 0.645 rs2645487 chr17:57886125 T/G cg02344993 chr17:57696989 CLTC 0.67 8.16 0.45 1.33e-14 Hemoglobin concentration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18909525 chr9:132403873 ASB6 -0.45 -6.28 -0.36 1.35e-9 Gambling; CESC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg22467129 chr15:76604101 ETFA -0.39 -5.91 -0.34 1.06e-8 Blood metabolite levels; CESC cis rs428668 0.523 rs6898671 chr5:150677643 A/T cg14086364 chr5:150678334 SLC36A3 0.5 7.32 0.41 2.93e-12 Skin aging (microtopography measurement); CESC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg24879335 chr3:133465180 TF 0.36 6.32 0.36 1.1e-9 Iron status biomarkers; CESC cis rs6088580 0.634 rs6059851 chr20:33047945 G/A cg24642439 chr20:33292090 TP53INP2 0.52 6.82 0.39 6.01e-11 Glomerular filtration rate (creatinine); CESC cis rs4728302 0.869 rs6467510 chr7:133607968 A/G cg10665199 chr7:133106180 EXOC4 0.4 5.61 0.33 4.98e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7927771 0.524 rs7110300 chr11:47848442 T/G cg18512352 chr11:47633146 NA 0.35 5.33 0.31 2.05e-7 Subjective well-being; CESC cis rs13385 0.769 rs12717954 chr5:139595299 C/T cg26211634 chr5:139558579 C5orf32 0.46 5.13 0.3 5.68e-7 Atrial fibrillation; CESC cis rs2228479 0.717 rs34027607 chr16:89808939 T/C cg14709524 chr16:89940631 TCF25 0.63 5.69 0.33 3.43e-8 Skin colour saturation; CESC cis rs1018836 0.608 rs1015994 chr8:91465011 T/C cg16814680 chr8:91681699 NA -0.51 -7.15 -0.4 8.32e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1801251 0.896 rs2197563 chr2:233687080 G/A cg08000102 chr2:233561755 GIGYF2 -0.72 -11.45 -0.58 6.41e-25 Coronary artery disease; CESC cis rs1878931 0.501 rs28735976 chr16:3418419 G/A cg22508957 chr16:3507546 NAT15 -0.38 -5.54 -0.32 7.15e-8 Body mass index (adult); CESC cis rs17826219 0.561 rs4085382 chr17:29071202 T/C cg14008862 chr17:28927542 LRRC37B2 0.63 5.27 0.31 2.89e-7 Body mass index; CESC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg03709012 chr19:19516395 GATAD2A -1.01 -15.62 -0.69 2.01e-39 Tonsillectomy; CESC cis rs10885582 0.781 rs10159811 chr10:116293820 G/A cg17056676 chr10:116301354 ABLIM1 -0.28 -5.14 -0.3 5.47e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7116495 0.609 rs10450664 chr11:71636655 A/G cg26138937 chr11:71823887 C11orf51 -1.29 -8.25 -0.45 7.45e-15 Severe influenza A (H1N1) infection; CESC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg03240473 chr21:43526662 UMODL1;C21orf128 -0.42 -5.3 -0.31 2.42e-7 IgG glycosylation; CESC cis rs1568889 0.838 rs10835283 chr11:28214985 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 12.93 0.62 5.7e-30 Bipolar disorder; CESC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg15782153 chr7:917662 C7orf20 -0.47 -5.04 -0.3 8.47e-7 Cerebrospinal P-tau181p levels; CESC cis rs826838 0.967 rs12823908 chr12:38845686 T/C cg26384229 chr12:38710491 ALG10B 0.83 14.57 0.67 1.05e-35 Heart rate; CESC cis rs1949733 1.000 rs2140337 chr4:8502112 A/G cg11789530 chr4:8429930 ACOX3 0.76 10.74 0.55 1.45e-22 Response to antineoplastic agents; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02778551 chr7:1045947 C7orf50 -0.54 -6.3 -0.36 1.26e-9 Gut microbiome composition (summer); CESC cis rs2228479 0.867 rs12930056 chr16:89946649 C/A cg06558623 chr16:89946397 TCF25 1.06 8.98 0.48 5.17e-17 Skin colour saturation; CESC cis rs9682041 0.627 rs3772172 chr3:170077713 C/T cg11886554 chr3:170076028 SKIL -0.51 -5.19 -0.3 4.2e-7 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs2204008 0.627 rs1851117 chr12:38398987 G/T cg26384229 chr12:38710491 ALG10B 0.72 10.63 0.55 3.37e-22 Bladder cancer; CESC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg19077165 chr18:44547161 KATNAL2 -0.53 -7.54 -0.42 7.6e-13 Personality dimensions; CESC cis rs6088580 0.634 rs6088471 chr20:32932643 C/A cg24642439 chr20:33292090 TP53INP2 -0.53 -7.01 -0.4 2.02e-11 Glomerular filtration rate (creatinine); CESC trans rs61931739 0.613 rs61927732 chr12:33678166 T/C cg26384229 chr12:38710491 ALG10B -0.44 -6.26 -0.36 1.54e-9 Morning vs. evening chronotype; CESC cis rs1005224 0.782 rs34882722 chr14:76153896 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.41 -5.65 -0.33 4.13e-8 Large artery stroke; CESC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.42 0.32 1.34e-7 Major depressive disorder; CESC cis rs9910055 0.529 rs228764 chr17:42185469 A/G cg19774624 chr17:42201019 HDAC5 0.58 7.84 0.43 1.07e-13 Total body bone mineral density; CESC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg18904891 chr8:8559673 CLDN23 0.71 8.39 0.46 2.99e-15 Obesity-related traits; CESC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.18 0.36 2.37e-9 Bipolar disorder; CESC cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg08564027 chr20:61660810 NA 0.9 15.36 0.69 1.69e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg24399712 chr22:39784796 NA -0.74 -9.09 -0.49 2.32e-17 Intelligence (multi-trait analysis); CESC cis rs10924970 0.649 rs4659492 chr1:235482207 T/G cg26050004 chr1:235667680 B3GALNT2 0.44 5.11 0.3 6.16e-7 Asthma; CESC cis rs2635047 0.713 rs28666933 chr18:44762408 C/T cg24371990 chr18:44770781 NA 0.41 6.68 0.38 1.38e-10 Educational attainment; CESC cis rs9814567 0.752 rs6764764 chr3:134331167 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.49 6.44 0.37 5.44e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg03983811 chr10:99400441 PI4K2A -0.48 -6.41 -0.37 6.71e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs2228479 0.850 rs17227064 chr16:89816314 A/G cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs9323205 0.723 rs61985121 chr14:51705925 A/G cg23942311 chr14:51606299 NA -0.48 -5.45 -0.32 1.13e-7 Cancer; CESC cis rs11583043 1.000 rs35445887 chr1:101523639 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.64 0.33 4.44e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs7216064 1.000 rs7216064 chr17:65898809 G/A cg12091567 chr17:66097778 LOC651250 -0.75 -7.69 -0.43 2.84e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9937943 0.673 rs12922972 chr16:74494522 T/A cg01733217 chr16:74700730 RFWD3 0.63 5.48 0.32 1.01e-7 Neutrophil percentage of white cells; CESC cis rs854765 0.547 rs4072739 chr17:17884660 G/A cg16928487 chr17:17741425 SREBF1 -0.48 -8.15 -0.45 1.43e-14 Total body bone mineral density; CESC cis rs6088590 1.000 rs2295353 chr20:33356511 C/T cg06115741 chr20:33292138 TP53INP2 0.6 7.24 0.41 4.87e-12 Coronary artery disease; CESC cis rs2228479 0.850 rs62054599 chr16:89808850 C/G cg06558623 chr16:89946397 TCF25 1.17 9.44 0.5 1.96e-18 Skin colour saturation; CESC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.52 7.86 0.43 9.89e-14 Bipolar disorder; CESC cis rs3862030 0.503 rs6584506 chr10:104254428 T/C cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs1005277 0.579 rs1780121 chr10:38529437 C/A cg25427524 chr10:38739819 LOC399744 -0.7 -10.26 -0.53 5.29e-21 Extrinsic epigenetic age acceleration; CESC cis rs12220238 0.818 rs10824082 chr10:75904080 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.66 6.68 0.38 1.42e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs34172651 0.876 rs11074653 chr16:24795959 C/T cg06028605 chr16:24865363 SLC5A11 0.41 6.22 0.36 1.94e-9 Intelligence (multi-trait analysis); CESC cis rs7584330 0.554 rs10176035 chr2:238433449 T/C cg14458575 chr2:238380390 NA 0.49 5.42 0.32 1.35e-7 Prostate cancer; CESC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg16325326 chr1:53192061 ZYG11B 0.82 12.71 0.62 3.3e-29 Monocyte count; CESC cis rs7267979 0.966 rs4815414 chr20:25361701 A/G cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.88e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9640161 0.789 rs4554381 chr7:150025567 G/A cg10018233 chr7:150070692 REPIN1 0.46 7.48 0.42 1.12e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg06494592 chr3:125709126 NA -0.48 -5.09 -0.3 6.89e-7 Blood pressure (smoking interaction); CESC cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg05340658 chr4:99064831 C4orf37 0.78 11.83 0.59 3.21e-26 Colonoscopy-negative controls vs population controls; CESC cis rs9399137 0.507 rs7772031 chr6:135259734 G/A cg24558204 chr6:135376177 HBS1L -0.69 -9.42 -0.5 2.34e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs3008870 0.755 rs4655660 chr1:67402953 G/A cg02640540 chr1:67518911 SLC35D1 0.46 5.58 0.32 5.81e-8 Lymphocyte percentage of white cells; CESC cis rs7824557 0.806 rs34171564 chr8:11095346 C/A cg21775007 chr8:11205619 TDH -0.35 -5.12 -0.3 5.89e-7 Retinal vascular caliber; CESC cis rs4237845 0.837 rs7963992 chr12:58295949 G/C cg02175503 chr12:58329896 NA 0.56 7.28 0.41 3.7e-12 Intelligence (multi-trait analysis); CESC cis rs2204008 0.744 rs11181337 chr12:38322083 C/A cg26384229 chr12:38710491 ALG10B 0.58 8.32 0.46 4.65e-15 Bladder cancer; CESC cis rs8180040 0.726 rs7625070 chr3:47095518 A/G cg27129171 chr3:47204927 SETD2 0.72 11.05 0.56 1.3e-23 Colorectal cancer; CESC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg26314531 chr2:26401878 FAM59B -0.61 -6.93 -0.39 3.12e-11 Gut microbiome composition (summer); CESC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg08470875 chr2:26401718 FAM59B 0.75 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC cis rs6831352 0.959 rs4699710 chr4:100051819 C/T cg12011299 chr4:100065546 ADH4 0.69 8.43 0.46 2.17e-15 Alcohol dependence; CESC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg02807482 chr3:125708958 NA -0.39 -5.11 -0.3 6.29e-7 Blood pressure (smoking interaction); CESC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Parkinson's disease; CESC cis rs7249142 0.549 rs12609573 chr19:19297567 C/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B -0.39 -5.24 -0.31 3.22e-7 IgG glycosylation; CESC cis rs1008375 0.932 rs6835077 chr4:17653285 A/T cg16339924 chr4:17578868 LAP3 0.71 8.87 0.48 1.09e-16 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg02376097 chr19:46275166 DMPK 0.38 5.48 0.32 9.84e-8 Coronary artery disease; CESC cis rs9894429 0.690 rs11869779 chr17:79570067 C/T cg13777783 chr17:79615861 NA 0.33 5.35 0.31 1.86e-7 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20308213 chr1:153700488 INTS3 0.54 6.34 0.36 1e-9 Gut microbiome composition (summer); CESC cis rs265548 0.538 rs36688 chr19:17911212 A/C cg04517722 chr19:17905589 B3GNT3 0.43 5.65 0.33 4.17e-8 Tumor biomarkers; CESC cis rs796364 0.806 rs74938253 chr2:201008386 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.64 -6.04 -0.35 5.26e-9 Schizophrenia; CESC cis rs12042938 0.935 rs823167 chr1:231767230 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.45 6.24 0.36 1.71e-9 Neuranatomic and neurocognitive phenotypes; CESC cis rs3743266 0.507 rs10162677 chr15:60748568 C/T cg22293140 chr15:60689852 ANXA2 -0.72 -7.62 -0.42 4.52e-13 Menarche (age at onset); CESC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg23758822 chr17:41437982 NA 1.01 15.21 0.68 5.44e-38 Menopause (age at onset); CESC cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg05340658 chr4:99064831 C4orf37 0.83 12.91 0.62 6.52e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9300255 0.602 rs1790098 chr12:123655481 A/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.34 -0.36 9.76e-10 Neutrophil percentage of white cells; CESC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -10.93 -0.56 3.43e-23 Extrinsic epigenetic age acceleration; CESC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.17 0.4 7.53e-12 Bipolar disorder; CESC cis rs4924935 1.000 rs2158100 chr17:18811479 A/G cg26378065 chr17:18585709 ZNF286B -0.51 -6.22 -0.36 1.9e-9 Pancreatic cancer; CESC cis rs5758511 0.514 rs5758626 chr22:42572363 G/A cg00645731 chr22:42541494 CYP2D7P1 0.6 9.07 0.49 2.73e-17 Birth weight; CESC cis rs9733 0.687 rs11204735 chr1:150841667 T/C cg18016565 chr1:150552671 MCL1 -0.35 -5.74 -0.33 2.55e-8 Tonsillectomy; CESC cis rs13082711 0.516 rs1388786 chr3:27372222 G/A cg02860705 chr3:27208620 NA -0.48 -5.98 -0.34 7.26e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg06212747 chr3:49208901 KLHDC8B 0.64 8.56 0.47 8.99e-16 Parkinson's disease; CESC cis rs6582630 0.519 rs8189461 chr12:38374870 G/T cg26384229 chr12:38710491 ALG10B 0.73 10.95 0.56 2.81e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs2070997 0.667 rs10901291 chr9:133717881 C/T cg11464064 chr9:133710261 ABL1 0.67 7.43 0.42 1.49e-12 Response to amphetamines; CESC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg01341218 chr17:43662625 NA -0.85 -10.25 -0.53 5.55e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7301826 0.627 rs4334059 chr12:131314214 T/C cg11011512 chr12:131303247 STX2 0.48 5.76 0.33 2.34e-8 Plasma plasminogen activator levels; CESC cis rs6432018 0.927 rs11674777 chr2:9734350 T/A cg23886495 chr2:9695866 ADAM17 0.43 5.08 0.3 7.2e-7 Heart rate variability traits; CESC cis rs11098499 0.955 rs35197422 chr4:120169314 T/G cg09307838 chr4:120376055 NA 0.86 11.39 0.57 9.73e-25 Corneal astigmatism; CESC cis rs113835537 0.935 rs75863187 chr11:66443461 G/A cg22134325 chr11:66188745 NPAS4 0.51 5.84 0.34 1.55e-8 Airway imaging phenotypes; CESC cis rs2932538 0.922 rs12401734 chr1:113071834 A/G cg22162597 chr1:113214053 CAPZA1 0.59 7.13 0.4 9.26e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs3008870 1.000 rs2065001 chr1:67486509 C/G cg02640540 chr1:67518911 SLC35D1 0.48 5.04 0.3 8.7e-7 Lymphocyte percentage of white cells; CESC cis rs12956009 0.518 rs4458096 chr18:44819555 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.49 -6.52 -0.37 3.48e-10 Educational attainment (years of education); CESC cis rs4077515 0.577 rs3812584 chr9:139312719 C/T cg14169450 chr9:139327907 INPP5E -0.49 -7.27 -0.41 3.99e-12 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg00310523 chr12:86230176 RASSF9 0.35 5.39 0.31 1.59e-7 Major depressive disorder; CESC cis rs9549367 0.713 rs510160 chr13:113822481 A/G cg00898013 chr13:113819073 PROZ 0.44 6.56 0.37 2.82e-10 Platelet distribution width; CESC cis rs12410462 0.681 rs115959512 chr1:227599578 T/C cg04117972 chr1:227635322 NA 0.81 6.43 0.37 5.82e-10 Major depressive disorder; CESC cis rs71403859 0.502 rs8051974 chr16:71488771 C/T cg08717414 chr16:71523259 ZNF19 -0.9 -9.4 -0.5 2.63e-18 Post bronchodilator FEV1; CESC cis rs2273669 0.588 rs11153151 chr6:109316754 C/G cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg21433313 chr16:3507492 NAT15 0.5 7.91 0.44 7.08e-14 Tuberculosis; CESC cis rs62012628 0.527 rs12438008 chr15:79084680 C/T cg00639195 chr15:79103007 ADAMTS7 0.46 5.99 0.35 6.92e-9 Diastolic blood pressure; CESC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg11494091 chr17:61959527 GH2 0.57 8.84 0.48 1.34e-16 Prudent dietary pattern; CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg11235426 chr6:292522 DUSP22 0.72 9.52 0.5 1.17e-18 Menopause (age at onset); CESC cis rs9660992 0.710 rs1151787 chr1:205254238 G/A cg00857998 chr1:205179979 DSTYK 0.47 5.36 0.31 1.81e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs12780046 0.611 rs2488344 chr10:100944931 T/C cg27143070 chr10:101087766 CNNM1 -0.41 -5.74 -0.33 2.53e-8 Non-glioblastoma glioma; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg21068339 chr6:7542819 DSP -0.49 -6.57 -0.37 2.65e-10 Height; CESC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg18758796 chr5:131593413 PDLIM4 0.46 6.59 0.38 2.35e-10 Breast cancer; CESC cis rs904251 0.523 rs914348 chr6:37484729 G/A cg01843034 chr6:37503916 NA -0.29 -5.35 -0.31 1.89e-7 Cognitive performance; CESC cis rs12477438 0.765 rs4374423 chr2:99662348 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs2635047 0.967 rs1355593 chr18:44746460 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 5.93 0.34 9.28e-9 Educational attainment; CESC cis rs2576037 0.521 rs4986227 chr18:44595031 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 5.84 0.34 1.54e-8 Personality dimensions; CESC cis rs921968 0.573 rs684776 chr2:219324016 T/C cg02176678 chr2:219576539 TTLL4 0.5 8.91 0.48 8.22e-17 Mean corpuscular hemoglobin concentration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26796815 chr5:134094372 DDX46 -0.43 -6.05 -0.35 5.01e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg12483801 chr4:183727862 NA 0.75 7.04 0.4 1.62e-11 Pediatric autoimmune diseases; CESC cis rs2629540 0.544 rs2629529 chr10:126534415 A/C cg08799069 chr10:126477246 METTL10 0.5 5.73 0.33 2.7e-8 Cocaine dependence; CESC cis rs10788264 0.569 rs10749454 chr10:124029654 C/T cg09507567 chr10:124027408 NA 0.39 6.13 0.35 3.15e-9 Total body bone mineral density; CESC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg05585544 chr11:47624801 NA 0.47 6.95 0.39 2.88e-11 Subjective well-being; CESC cis rs7523050 0.730 rs34182354 chr1:109416340 C/T cg08274380 chr1:109419600 GPSM2 0.94 6.44 0.37 5.73e-10 Fat distribution (HIV); CESC cis rs1665050 0.901 rs1665051 chr15:59295224 A/G cg05156742 chr15:59063176 FAM63B 0.42 5.24 0.31 3.31e-7 Atopic dermatitis; CESC cis rs704 0.585 rs3093680 chr17:26664806 T/C cg10494684 chr17:26645200 TMEM97 -0.4 -5.54 -0.32 7.38e-8 Osteoprotegerin levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06722069 chr3:113822382 NA -0.47 -6.48 -0.37 4.33e-10 Gut microbiota (bacterial taxa); CESC cis rs6489785 0.562 rs494632 chr12:121189116 C/T cg02419362 chr12:121203948 SPPL3 0.34 5.45 0.32 1.13e-7 Longevity;Allergic disease (asthma, hay fever or eczema); CESC cis rs6693567 0.565 rs11205371 chr1:150398510 A/G cg09579323 chr1:150459698 TARS2 0.48 5.99 0.35 6.73e-9 Migraine; CESC cis rs9747201 0.862 rs57596657 chr17:80147978 C/T cg09264619 chr17:80180166 NA -0.42 -5.05 -0.3 8.04e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs8099014 0.725 rs4940691 chr18:56095378 T/G cg12827950 chr18:55968429 NEDD4L -0.48 -5.15 -0.3 5.19e-7 Platelet count; CESC cis rs2204008 0.713 rs2320522 chr12:38251438 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.26 0.53 5.3e-21 Bladder cancer; CESC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03352830 chr11:487213 PTDSS2 0.71 7.25 0.41 4.71e-12 Body mass index; CESC cis rs4076764 0.846 rs10753616 chr1:163415855 G/T cg24596788 chr1:163392923 NA 0.4 5.62 0.33 4.88e-8 Motion sickness; CESC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs6942756 0.955 rs2056694 chr7:128923817 C/T cg02491457 chr7:128862824 NA -0.69 -9.23 -0.49 8.71e-18 White matter hyperintensity burden; CESC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.39 0.77 9.4e-53 Height; CESC cis rs35146811 0.586 rs10267212 chr7:99595422 T/C cg22531904 chr7:99595276 NA -0.38 -5.04 -0.3 8.84e-7 Coronary artery disease; CESC cis rs9522267 0.535 rs9515451 chr13:112234382 A/G cg10483660 chr13:112241077 NA -0.33 -5.79 -0.33 2.04e-8 Hepatitis; CESC cis rs2932538 0.922 rs12125361 chr1:113144779 C/T cg22162597 chr1:113214053 CAPZA1 0.58 7.29 0.41 3.64e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs4722166 0.645 rs1404006 chr7:22795077 T/C cg13104385 chr7:22767384 IL6 0.39 5.78 0.33 2.11e-8 Lung cancer; CESC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs7091068 0.522 rs11187621 chr10:95483074 T/C cg20715218 chr10:95462985 C10orf4 0.5 5.89 0.34 1.14e-8 Urinary tract infection frequency; CESC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg26338869 chr17:61819248 STRADA 0.69 9.08 0.49 2.62e-17 Prudent dietary pattern; CESC cis rs7264396 0.790 rs4519606 chr20:34324648 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -10.23 -0.53 6.57e-21 Total cholesterol levels; CESC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs4253772 0.550 rs6007761 chr22:46670394 C/T cg09491104 chr22:46646882 C22orf40 0.52 7.98 0.44 4.54e-14 LDL cholesterol;Cholesterol, total; CESC cis rs9322193 0.566 rs5024811 chr6:150246034 A/G cg01145232 chr6:150245071 RAET1G -0.49 -6.54 -0.37 3.13e-10 Lung cancer; CESC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg12963246 chr6:28129442 ZNF389 0.54 7.12 0.4 1.02e-11 Depression; CESC cis rs3768617 0.811 rs4396114 chr1:183007441 C/T ch.1.3577855R chr1:183094577 LAMC1 0.65 8.79 0.48 1.91e-16 Fuchs's corneal dystrophy; CESC cis rs4243830 0.579 rs10779794 chr1:6612651 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.79 -7.84 -0.43 1.12e-13 Body mass index; CESC cis rs8044868 0.530 rs7940 chr16:72146441 C/G cg16558253 chr16:72132732 DHX38 -0.39 -6.08 -0.35 4.07e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs8005677 0.828 rs4981451 chr14:23410281 T/C cg01529538 chr14:23388837 RBM23 0.44 5.83 0.34 1.63e-8 Cognitive ability (multi-trait analysis); CESC cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs13095912 0.785 rs62291882 chr3:185313278 T/C cg11274856 chr3:185301563 NA 0.4 6.07 0.35 4.38e-9 Systolic blood pressure; CESC cis rs1215050 0.765 rs687795 chr4:98754912 C/G cg05340658 chr4:99064831 C4orf37 0.51 6.65 0.38 1.63e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg12927641 chr6:109611667 NA -0.41 -6.43 -0.37 6e-10 Reticulocyte fraction of red cells; CESC trans rs61931739 0.534 rs1490113 chr12:34132394 A/G cg26384229 chr12:38710491 ALG10B 0.6 8.37 0.46 3.38e-15 Morning vs. evening chronotype; CESC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg25072359 chr17:41440525 NA 0.47 6.17 0.35 2.61e-9 Menopause (age at onset); CESC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg00149659 chr3:10157352 C3orf10 0.74 9.14 0.49 1.63e-17 Alzheimer's disease; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg18386867 chr2:39347986 SOS1 0.48 6.07 0.35 4.42e-9 Psoriatic arthritis; CESC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg01570182 chr17:44337453 NA -0.62 -8.41 -0.46 2.56e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg02725872 chr8:58115012 NA -0.42 -6.64 -0.38 1.79e-10 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04204557 chr21:46065774 KRTAP10-11;C21orf29 -0.58 -7.03 -0.4 1.75e-11 Gut microbiome composition (summer); CESC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg12311346 chr5:56204834 C5orf35 -0.84 -9.86 -0.52 1e-19 Initial pursuit acceleration; CESC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg22535103 chr8:58192502 C8orf71 -0.9 -8.95 -0.48 6.29e-17 Developmental language disorder (linguistic errors); CESC cis rs4253772 0.513 rs9615345 chr22:46713631 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.78 9.06 0.49 2.86e-17 LDL cholesterol;Cholesterol, total; CESC cis rs4268898 0.662 rs72795832 chr2:24441855 C/A cg20701182 chr2:24300061 SF3B14 0.61 6.56 0.37 2.85e-10 Asthma; CESC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs10883723 0.810 rs7094366 chr10:104274730 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.58 7.73 0.43 2.29e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs2777491 0.872 rs7163649 chr15:41586798 A/G cg02330683 chr15:41787940 ITPKA 0.42 6.13 0.35 3.21e-9 Ulcerative colitis; CESC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg18446336 chr7:2847575 GNA12 -0.41 -6.28 -0.36 1.38e-9 Height; CESC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.61 7.83 0.43 1.21e-13 Menopause (age at onset); CESC cis rs11098499 0.775 rs10029303 chr4:120286755 T/A cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs4944092 1.000 rs7125695 chr11:75908131 A/G cg04588336 chr11:75916460 WNT11 0.48 7.6 0.42 5.29e-13 PR interval; CESC cis rs72945132 0.769 rs680571 chr11:70187441 G/A cg00319359 chr11:70116639 PPFIA1 0.71 6.92 0.39 3.49e-11 Coronary artery disease; CESC cis rs34638657 0.872 rs6420437 chr16:82187181 T/C cg09439754 chr16:82129088 HSD17B2 -0.35 -5.24 -0.31 3.26e-7 Lung adenocarcinoma; CESC cis rs77216612 1.000 rs77216612 chr12:12877983 A/G cg09462578 chr12:12878428 APOLD1 -1.01 -15.31 -0.69 2.4e-38 Lymphocyte counts; CESC cis rs17490626 0.568 rs12416520 chr10:71211945 A/G cg12610070 chr10:71211762 TSPAN15 -0.32 -6.95 -0.39 2.87e-11 Thrombosis; CESC cis rs7772486 0.875 rs2492855 chr6:146296926 A/G cg23711669 chr6:146136114 FBXO30 0.75 10.79 0.55 9.68e-23 Lobe attachment (rater-scored or self-reported); CESC trans rs877282 0.898 rs2004478 chr10:770709 C/A cg22713356 chr15:30763199 NA 1.15 11.42 0.57 7.63e-25 Uric acid levels; CESC cis rs7829975 0.742 rs12547493 chr8:8661534 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -6.22 -0.36 1.97e-9 Mood instability; CESC cis rs2011503 0.891 rs2965190 chr19:19451591 A/G cg11584989 chr19:19387371 SF4 -0.63 -7.55 -0.42 7.15e-13 Bipolar disorder; CESC cis rs4535700 0.501 rs57153841 chr7:55995093 G/A cg09872392 chr7:56161020 PHKG1 0.41 5.76 0.33 2.37e-8 Macular telangiectasia type 2; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09872104 chr7:134855509 C7orf49 0.55 6.54 0.37 3.12e-10 Gut microbiome composition (summer); CESC cis rs13064411 0.660 rs1872747 chr3:113175785 T/A cg18753928 chr3:113234510 CCDC52 -0.48 -5.19 -0.3 4.16e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs1707322 1.000 rs946527 chr1:46485970 C/T cg05343316 chr1:45956843 TESK2 0.44 5.46 0.32 1.08e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9488822 0.596 rs13206506 chr6:116324460 A/G cg05304507 chr6:116381966 FRK 0.22 5.43 0.32 1.26e-7 Cholesterol, total;LDL cholesterol; CESC cis rs4812048 0.901 rs151354 chr20:57606971 A/G cg14073986 chr20:57617431 SLMO2 0.54 5.73 0.33 2.72e-8 Mean platelet volume; CESC cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg06697600 chr4:7070879 GRPEL1 0.49 5.89 0.34 1.16e-8 Monocyte percentage of white cells; CESC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg17372223 chr3:52568218 NT5DC2 0.42 6.45 0.37 5.23e-10 Bipolar disorder; CESC cis rs2249625 0.967 rs1973843 chr6:72919181 A/G cg18830697 chr6:72922368 RIMS1 -0.42 -5.85 -0.34 1.48e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs7940866 0.845 rs2324314 chr11:130834589 A/C cg12179176 chr11:130786555 SNX19 0.65 9.18 0.49 1.31e-17 Schizophrenia; CESC cis rs447 0.945 rs4141151 chr7:83737361 A/G cg22846510 chr7:83753280 SEMA3A -0.43 -5.27 -0.31 2.81e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9309473 0.500 rs4286298 chr2:73882108 T/A cg20560298 chr2:73613845 ALMS1 0.5 6.96 0.39 2.61e-11 Metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17274881 chr4:79103244 FRAS1 0.42 6.01 0.35 6.23e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19586661 chr11:66079705 NA 0.6 7.19 0.4 6.66e-12 Gut microbiome composition (summer); CESC cis rs8049040 0.609 rs11866859 chr16:71478888 G/A cg08717414 chr16:71523259 ZNF19 -0.65 -7.25 -0.41 4.51e-12 Blood protein levels; CESC cis rs910316 0.810 rs77939209 chr14:75670070 A/G cg08847533 chr14:75593920 NEK9 -0.95 -17.02 -0.72 2.09e-44 Height; CESC cis rs9291683 0.509 rs10939671 chr4:10050815 T/C cg02734326 chr4:10020555 SLC2A9 0.45 6.45 0.37 5.27e-10 Bone mineral density; CESC cis rs4417704 0.551 rs4675841 chr2:241876580 A/G cg05025159 chr2:241905733 NA 0.33 5.19 0.3 4.28e-7 Joint mobility (Beighton score); CESC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg06634786 chr22:41940651 POLR3H 0.72 7.43 0.42 1.46e-12 Vitiligo; CESC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -8.12 -0.45 1.72e-14 Alzheimer's disease; CESC cis rs2073300 0.609 rs2295238 chr20:23387946 C/G cg16736954 chr20:23401023 NAPB 0.65 5.67 0.33 3.67e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2075671 0.903 rs11979818 chr7:100293639 A/G cg20848291 chr7:100343083 ZAN 0.76 9.8 0.52 1.55e-19 Other erythrocyte phenotypes; CESC trans rs11098499 0.566 rs17051356 chr4:120585308 C/T cg25214090 chr10:38739885 LOC399744 0.61 8.15 0.45 1.5e-14 Corneal astigmatism; CESC cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg05343316 chr1:45956843 TESK2 -0.52 -6.69 -0.38 1.33e-10 High light scatter reticulocyte count; CESC cis rs12220238 1.000 rs7909664 chr10:75869754 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.69 6.75 0.38 9.49e-11 Soluble interleukin-2 receptor subunit alpha; CESC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Depression; CESC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg04772025 chr11:68637568 NA 0.5 5.88 0.34 1.2e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs539096 0.540 rs3011217 chr1:44303266 C/T cg12908607 chr1:44402522 ARTN 0.46 6.79 0.39 7.21e-11 Intelligence (multi-trait analysis); CESC cis rs7914558 0.966 rs10748835 chr10:104660256 C/T cg15744005 chr10:104629667 AS3MT -0.34 -5.27 -0.31 2.82e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs8067354 0.645 rs2645489 chr17:57883371 T/G cg02344993 chr17:57696989 CLTC 0.67 8.16 0.45 1.33e-14 Hemoglobin concentration; CESC cis rs6540556 0.517 rs11119328 chr1:209885318 C/A cg05527609 chr1:210001259 C1orf107 -0.73 -7.23 -0.41 5.07e-12 Red blood cell count; CESC cis rs1670533 0.872 rs6854793 chr4:1055768 T/C cg27284194 chr4:1044797 NA 0.47 5.99 0.35 6.72e-9 Recombination rate (females); CESC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.89 10.07 0.53 2.12e-20 Platelet count; CESC cis rs1215050 0.765 rs644839 chr4:98716357 C/A cg05340658 chr4:99064831 C4orf37 0.51 6.48 0.37 4.45e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg23158103 chr7:148848205 ZNF398 -0.4 -6.3 -0.36 1.22e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9910055 0.530 rs8072954 chr17:42294722 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.35 5.14 0.3 5.28e-7 Total body bone mineral density; CESC cis rs2050392 0.517 rs2480299 chr10:30743197 G/A cg25182066 chr10:30743637 MAP3K8 -0.56 -8.22 -0.45 9.2e-15 Inflammatory bowel disease; CESC cis rs4604732 0.578 rs79203328 chr1:247626581 C/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2425143 1.000 rs11699044 chr20:34312713 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.79 8.19 0.45 1.08e-14 Blood protein levels; CESC cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg15541040 chr2:3486749 NA -0.44 -5.52 -0.32 7.89e-8 Neurofibrillary tangles; CESC cis rs4803468 1.000 rs166925 chr19:41926098 T/C cg09537434 chr19:41945824 ATP5SL -1.1 -20.33 -0.78 5.18e-56 Height; CESC cis rs2072499 0.966 rs2853643 chr1:156184831 G/A cg24450063 chr1:156163899 SLC25A44 0.92 14.14 0.66 3.37e-34 Testicular germ cell tumor; CESC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg25036284 chr2:26402008 FAM59B -0.85 -9.51 -0.5 1.22e-18 Gut microbiome composition (summer); CESC cis rs3857536 0.706 rs2157963 chr6:66945449 A/T cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.48 5.44 0.32 1.22e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg19774624 chr17:42201019 HDAC5 0.57 7.47 0.42 1.18e-12 Total body bone mineral density; CESC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg18876405 chr7:65276391 NA 0.5 6.5 0.37 3.98e-10 Aortic root size; CESC cis rs8070624 0.543 rs4299203 chr17:17878159 T/G cg04398451 chr17:18023971 MYO15A -0.69 -9.51 -0.5 1.19e-18 Total body bone mineral density; CESC cis rs11148252 0.508 rs6561671 chr13:53182314 G/A cg00495681 chr13:53174319 NA 0.53 7.23 0.41 5.15e-12 Lewy body disease; CESC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg08859206 chr1:53392774 SCP2 0.62 9.09 0.49 2.37e-17 Monocyte count; CESC cis rs1538970 0.924 rs1494812 chr1:45876999 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.49 0.32 9.28e-8 Platelet count; CESC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg16325326 chr1:53192061 ZYG11B 0.61 8.92 0.48 8.04e-17 Monocyte count; CESC cis rs7799006 0.929 rs35629140 chr7:2257171 G/C cg12745145 chr7:2261452 MAD1L1 -0.43 -6.56 -0.37 2.89e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg00908189 chr16:619842 PIGQ 0.64 8.96 0.48 6.04e-17 Height; CESC cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg10792982 chr14:105748885 BRF1 0.42 5.36 0.31 1.81e-7 Mean platelet volume;Platelet distribution width; CESC cis rs9814567 1.000 rs9289478 chr3:134268619 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.82 -0.34 1.69e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs1814175 0.533 rs4528310 chr11:49983106 C/A cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.49e-38 Height; CESC cis rs6456156 0.586 rs12528323 chr6:167461645 A/G cg07741184 chr6:167504864 NA 0.35 6.0 0.35 6.57e-9 Primary biliary cholangitis; CESC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg22823121 chr1:150693482 HORMAD1 0.48 6.59 0.38 2.39e-10 Melanoma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07148452 chr15:90176987 KIF7 0.53 7.0 0.4 2.16e-11 Fibrinogen levels; CESC cis rs2299587 0.527 rs10112643 chr8:17726019 A/G cg08627089 chr8:17753878 FGL1 -0.39 -5.56 -0.32 6.49e-8 Economic and political preferences; CESC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg11764359 chr7:65958608 NA -0.7 -9.73 -0.51 2.51e-19 Aortic root size; CESC cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg16339924 chr4:17578868 LAP3 -0.65 -7.88 -0.44 8.45e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg04414720 chr1:150670196 GOLPH3L 0.62 8.72 0.47 3.14e-16 Tonsillectomy; CESC cis rs796364 0.806 rs10931887 chr2:200968905 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -6.49 -0.37 4.2e-10 Schizophrenia; CESC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.34 0.41 2.56e-12 Electroencephalogram traits; CESC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Tonsillectomy; CESC cis rs11785400 0.928 rs10100287 chr8:143734836 C/T cg24634471 chr8:143751801 JRK 0.46 5.9 0.34 1.14e-8 Schizophrenia; CESC cis rs2204008 0.571 rs7970136 chr12:38531951 G/C cg26384229 chr12:38710491 ALG10B -0.41 -5.44 -0.32 1.18e-7 Bladder cancer; CESC cis rs75477785 1.000 rs76145088 chr1:209989232 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs7680126 0.500 rs4697933 chr4:10146493 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -6.15 -0.35 2.82e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.45 5.44 0.32 1.21e-7 Tonsillectomy; CESC cis rs3845702 1.000 rs3845702 chr2:180848488 A/C cg01881094 chr2:180872142 CWC22 0.66 7.36 0.41 2.26e-12 Schizophrenia; CESC cis rs3768617 0.510 rs2224933 chr1:183095765 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg15664640 chr17:80829946 TBCD -0.66 -9.37 -0.5 3.34e-18 Breast cancer; CESC cis rs6460942 1.000 rs2053381 chr7:12400710 C/A cg13733410 chr7:12443478 VWDE -0.53 -5.26 -0.31 2.95e-7 Coronary artery disease; CESC cis rs7000551 0.689 rs6993341 chr8:22310933 T/C cg12081754 chr8:22256438 SLC39A14 0.41 5.3 0.31 2.39e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs4891159 0.756 rs55763305 chr18:74161249 G/C cg24786174 chr18:74118243 ZNF516 -0.7 -10.27 -0.53 4.72e-21 Longevity; CESC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg07677032 chr17:61819896 STRADA 0.55 7.64 0.42 4e-13 Prudent dietary pattern; CESC cis rs1005277 0.505 rs7099777 chr10:38183569 A/C cg00409905 chr10:38381863 ZNF37A 0.56 7.82 0.43 1.28e-13 Extrinsic epigenetic age acceleration; CESC cis rs12701220 0.947 rs1007765 chr7:1032805 G/C cg26769984 chr7:1090371 C7orf50 0.65 7.19 0.4 6.74e-12 Bronchopulmonary dysplasia; CESC cis rs7772486 0.875 rs9322048 chr6:146400439 A/G cg23711669 chr6:146136114 FBXO30 0.76 11.21 0.57 3.86e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs6546537 0.562 rs1985342 chr2:69758927 C/T cg10773587 chr2:69614142 GFPT1 -0.53 -6.57 -0.37 2.58e-10 Serum thyroid-stimulating hormone levels; CESC cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg21918786 chr6:109611834 NA 0.4 5.95 0.34 8.24e-9 Reticulocyte fraction of red cells; CESC cis rs796364 0.806 rs203765 chr2:200903020 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.87 -8.14 -0.45 1.58e-14 Schizophrenia; CESC cis rs7772486 0.875 rs2328712 chr6:146344563 T/C cg23711669 chr6:146136114 FBXO30 0.77 11.07 0.56 1.17e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs6714710 0.603 rs12995673 chr2:98409046 G/A cg26665480 chr2:98280029 ACTR1B 0.65 8.99 0.48 4.71e-17 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs4870684 1.000 rs4870684 chr7:57699151 C/T cg01314568 chr7:57830625 NA -0.49 -6.44 -0.37 5.62e-10 Bipolar disorder and schizophrenia; CESC cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg02297831 chr4:17616191 MED28 -0.52 -6.62 -0.38 2.01e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs763121 0.853 rs1062687 chr22:39134715 T/C cg06544989 chr22:39130855 UNC84B 0.5 9.5 0.5 1.34e-18 Menopause (age at onset); CESC trans rs11098499 0.955 rs1511018 chr4:120161580 G/T cg25214090 chr10:38739885 LOC399744 0.64 8.58 0.47 8.37e-16 Corneal astigmatism; CESC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg14664628 chr15:75095509 CSK -0.53 -6.73 -0.38 1.04e-10 Breast cancer; CESC cis rs7165102 1.000 rs17809330 chr15:65889250 C/T cg11441148 chr15:65824328 PTPLAD1 -0.31 -5.12 -0.3 5.77e-7 Mean corpuscular hemoglobin; CESC cis rs666930 0.519 rs662602 chr1:120266903 C/G cg19096424 chr1:120255104 PHGDH 0.72 8.28 0.45 6.19e-15 Breast cancer; CESC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.42e-7 Lung cancer; CESC cis rs738322 0.935 rs2413503 chr22:38568944 A/T cg17652424 chr22:38574118 PLA2G6 -0.34 -6.03 -0.35 5.34e-9 Cutaneous nevi; CESC cis rs9291683 0.552 rs10939655 chr4:10014642 A/T cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.16e-46 Bone mineral density; CESC cis rs9831754 0.756 rs9817660 chr3:78426373 T/C cg06138941 chr3:78371609 NA -0.49 -6.27 -0.36 1.5e-9 Calcium levels; CESC cis rs926938 0.527 rs360685 chr1:115499795 G/C cg12756093 chr1:115239321 AMPD1 0.45 6.15 0.35 2.84e-9 Autism; CESC cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg11952622 chr19:58962976 ZNF324B 0.46 6.13 0.35 3.16e-9 Uric acid clearance; CESC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg23758822 chr17:41437982 NA 0.99 15.34 0.69 1.98e-38 Menopause (age at onset); CESC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg12463550 chr7:65579703 CRCP -0.61 -7.52 -0.42 8.3e-13 Aortic root size; CESC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg02375832 chr11:62437615 C11orf48 -0.35 -5.06 -0.3 7.83e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9325144 0.555 rs12424003 chr12:38688140 C/T cg26384229 chr12:38710491 ALG10B -0.6 -8.5 -0.46 1.44e-15 Morning vs. evening chronotype; CESC cis rs6669072 0.647 rs814547 chr1:91238821 T/C cg08895590 chr1:91227319 NA -0.34 -5.86 -0.34 1.39e-8 Cognitive function; CESC cis rs42648 0.869 rs1015402 chr7:89913269 C/T cg23697855 chr7:89950296 NA 0.27 5.05 0.3 8.24e-7 Homocysteine levels; CESC cis rs897080 0.515 rs2850290 chr2:44636055 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.5 0.32 9e-8 Height; CESC cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg16743903 chr16:89593216 SPG7 0.44 5.77 0.33 2.19e-8 Multiple myeloma (IgH translocation); CESC cis rs7246865 0.724 rs10424674 chr19:17183185 G/A cg16202187 chr19:17186497 HAUS8;MYO9B 0.45 5.35 0.31 1.94e-7 Reticulocyte fraction of red cells; CESC cis rs8141529 0.732 rs2239815 chr22:29192670 C/T cg02153584 chr22:29168773 CCDC117 -0.64 -9.45 -0.5 1.88e-18 Lymphocyte counts; CESC cis rs1218582 0.682 rs12046459 chr1:154912017 A/C cg16680214 chr1:154839983 KCNN3 -0.45 -6.87 -0.39 4.46e-11 Prostate cancer; CESC cis rs57244997 0.725 rs7754703 chr6:162440488 T/C cg17173639 chr6:162384350 PARK2 -0.44 -5.15 -0.3 5.14e-7 Mosquito bite size; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg11255513 chr11:113644528 ZW10 -0.45 -6.75 -0.38 9.21e-11 Vertical cup-disc ratio; CESC cis rs7246657 0.943 rs7258692 chr19:37818829 C/A cg23950597 chr19:37808831 NA -0.59 -6.14 -0.35 3.07e-9 Coronary artery calcification; CESC cis rs10504229 0.575 rs4590436 chr8:57996539 A/C cg24829409 chr8:58192753 C8orf71 -0.42 -5.5 -0.32 8.75e-8 Developmental language disorder (linguistic errors); CESC cis rs8092503 1.000 rs62091462 chr18:52488698 T/C cg12377874 chr18:52495404 RAB27B 0.39 6.42 0.37 6.43e-10 Childhood body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12546181 chr19:48902029 GRIN2D 0.53 6.07 0.35 4.46e-9 Gut microbiome composition (summer); CESC trans rs208520 0.526 rs6455072 chr6:66797215 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -24.95 -0.84 1.67e-71 Exhaled nitric oxide output; CESC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.28 0.63 3.39e-31 Prudent dietary pattern; CESC cis rs9611565 0.765 rs132908 chr22:41801795 G/A cg03806693 chr22:41940476 POLR3H 1.09 12.57 0.61 9.68e-29 Vitiligo; CESC cis rs4481887 1.000 rs4372295 chr1:248464871 G/T cg00666640 chr1:248458726 OR2T12 0.37 6.1 0.35 3.82e-9 Common traits (Other); CESC cis rs11030122 0.702 rs12223176 chr11:3982537 T/G cg18678763 chr11:4115507 RRM1 -0.49 -6.59 -0.38 2.4e-10 Mean platelet volume;Platelet distribution width; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05698020 chr13:111163978 COL4A2 -0.43 -6.39 -0.37 7.23e-10 Gut microbiota (bacterial taxa); CESC cis rs7917772 0.503 rs7100753 chr10:104300979 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.49 0.42 9.98e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1775715 0.707 rs1541261 chr10:32179523 G/A cg18675610 chr10:32216311 ARHGAP12 0.36 5.53 0.32 7.75e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.88 13.37 0.63 1.64e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4803468 0.935 rs13346603 chr19:41945837 T/A cg08639244 chr19:41945921 ATP5SL 0.43 5.33 0.31 2.12e-7 Height; CESC cis rs950776 0.518 rs62008174 chr15:78808947 C/T cg06917634 chr15:78832804 PSMA4 0.78 11.36 0.57 1.26e-24 Sudden cardiac arrest; CESC cis rs2286503 1.000 rs2286499 chr7:22857477 A/G cg13679077 chr7:22862647 TOMM7 0.41 5.25 0.31 3.08e-7 Fibrinogen; CESC cis rs807669 0.565 rs5746682 chr22:19185526 C/T cg02655711 chr22:19163373 SLC25A1 0.75 11.55 0.58 2.93e-25 Metabolite levels; CESC cis rs1707322 1.000 rs4641257 chr1:46353589 G/A cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg01097406 chr16:89675127 NA 0.38 5.41 0.32 1.42e-7 Vitiligo; CESC cis rs67311347 1.000 rs9968170 chr3:40494274 A/G cg09455208 chr3:40491958 NA -0.46 -7.59 -0.42 5.49e-13 Renal cell carcinoma; CESC cis rs7772486 0.875 rs2777477 chr6:146305491 A/G cg23711669 chr6:146136114 FBXO30 0.78 11.25 0.57 2.92e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs67460515 0.892 rs4856757 chr3:160999418 A/T cg03342759 chr3:160939853 NMD3 -0.53 -7.55 -0.42 7.23e-13 Parkinson's disease; CESC trans rs61931739 0.500 rs11053210 chr12:34461771 A/G cg13010199 chr12:38710504 ALG10B -0.53 -6.38 -0.36 7.64e-10 Morning vs. evening chronotype; CESC cis rs8018967 1.000 rs8018967 chr14:73976934 A/G cg09844916 chr14:74004424 HEATR4;ACOT1 0.45 5.74 0.33 2.57e-8 Blood metabolite ratios; CESC cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg01579765 chr21:45077557 HSF2BP -0.55 -9.0 -0.48 4.45e-17 Mean corpuscular volume; CESC cis rs13242816 1.000 rs55833477 chr7:116110375 C/G cg04696780 chr7:116139425 CAV2 -0.59 -5.24 -0.31 3.3e-7 P wave duration; CESC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.22e-17 Prudent dietary pattern; CESC cis rs193541 0.593 rs246309 chr5:122269719 A/C cg19412675 chr5:122181750 SNX24 0.42 5.04 0.3 8.46e-7 Glucose homeostasis traits; CESC cis rs6942756 0.531 rs9649530 chr7:128927406 G/A cg02491457 chr7:128862824 NA 0.44 6.19 0.36 2.34e-9 White matter hyperintensity burden; CESC cis rs7917772 0.503 rs10883732 chr10:104293461 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.17 0.3 4.66e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs763121 0.853 rs4821810 chr22:39072098 C/G cg14440974 chr22:39074834 NA -0.36 -5.21 -0.3 3.78e-7 Menopause (age at onset); CESC cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg18850127 chr7:39170497 POU6F2 0.38 5.28 0.31 2.65e-7 IgG glycosylation; CESC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.45 0.37 5.41e-10 Prudent dietary pattern; CESC cis rs9811920 0.535 rs704571 chr3:99481946 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.33 -5.42 -0.32 1.37e-7 Axial length; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25005279 chr10:135113451 TUBGCP2 -0.63 -6.93 -0.39 3.23e-11 Gut microbiome composition (summer); CESC trans rs61931739 0.517 rs12815556 chr12:34319670 G/A cg26384229 chr12:38710491 ALG10B 0.65 9.19 0.49 1.16e-17 Morning vs. evening chronotype; CESC cis rs1008375 1.000 rs2315560 chr4:17677305 C/G cg16339924 chr4:17578868 LAP3 0.51 6.44 0.37 5.73e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8017423 0.935 rs11624295 chr14:90695612 T/G cg14092571 chr14:90743983 NA -0.56 -8.19 -0.45 1.12e-14 Mortality in heart failure; CESC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.01 -0.35 6e-9 Total body bone mineral density; CESC cis rs6460942 0.915 rs2192842 chr7:12315752 C/G cg06484146 chr7:12443880 VWDE -0.39 -5.81 -0.34 1.82e-8 Coronary artery disease; CESC cis rs4319547 0.697 rs7974262 chr12:122896385 C/T cg05707623 chr12:122985044 ZCCHC8 0.55 6.21 0.36 2.01e-9 Body mass index; CESC cis rs9287719 0.967 rs2024431 chr2:10731327 A/G cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.35e-8 Prostate cancer; CESC cis rs7116495 0.609 rs2511120 chr11:71786211 C/T cg07596299 chr11:71824057 C11orf51 -0.85 -5.3 -0.31 2.42e-7 Severe influenza A (H1N1) infection; CESC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.64 5.44 0.32 1.21e-7 Depression; CESC cis rs1559088 0.947 rs12461219 chr19:33550633 C/G cg17764715 chr19:33622953 WDR88 0.45 5.67 0.33 3.76e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs11098499 0.909 rs28668716 chr4:120309875 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg15207953 chr20:29522467 NA 0.47 6.26 0.36 1.53e-9 Lung cancer in ever smokers; CESC cis rs4409675 0.576 rs6691656 chr1:28221130 C/G cg23691781 chr1:28212827 C1orf38 0.3 5.81 0.34 1.83e-8 Corneal astigmatism; CESC cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg05585544 chr11:47624801 NA -0.48 -6.98 -0.39 2.34e-11 Subjective well-being; CESC cis rs1215050 0.846 rs1839903 chr4:98791414 C/T cg05340658 chr4:99064831 C4orf37 0.54 6.42 0.37 6.44e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg00409905 chr10:38381863 ZNF37A -0.45 -6.04 -0.35 5.25e-9 Extrinsic epigenetic age acceleration; CESC trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21659725 chr3:3221576 CRBN -0.83 -13.62 -0.64 2.29e-32 Intelligence (multi-trait analysis); CESC cis rs17376456 0.877 rs10062711 chr5:93348659 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.04 0.3 8.63e-7 Diabetic retinopathy; CESC cis rs10752881 1.000 rs6424880 chr1:182986679 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.79e-31 Colorectal cancer; CESC cis rs8141529 0.509 rs7287124 chr22:29239157 A/G cg15103426 chr22:29168792 CCDC117 0.62 8.09 0.45 2.14e-14 Lymphocyte counts; CESC cis rs7107174 1.000 rs72931642 chr11:78037862 A/T cg02023728 chr11:77925099 USP35 0.52 6.86 0.39 4.74e-11 Testicular germ cell tumor; CESC cis rs1707322 0.827 rs6694302 chr1:46245645 A/T cg03146154 chr1:46216737 IPP 0.8 11.18 0.57 4.85e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2953174 0.507 rs2953172 chr2:241525316 C/T cg07929629 chr2:241523174 NA 0.64 8.13 0.45 1.7e-14 Bipolar disorder; CESC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg17971929 chr21:40555470 PSMG1 -0.56 -7.2 -0.4 6.35e-12 Menarche (age at onset); CESC cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg22875332 chr1:76189707 ACADM -0.63 -6.56 -0.37 2.83e-10 Blood metabolite levels;Acylcarnitine levels; CESC trans rs9929218 0.559 rs12923775 chr16:68756450 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.86 13.85 0.65 3.35e-33 Colorectal cancer; CESC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg05863683 chr7:1912471 MAD1L1 0.39 5.55 0.32 7.08e-8 Bipolar disorder and schizophrenia; CESC cis rs10791097 0.967 rs4366492 chr11:130717256 T/C cg14779329 chr11:130786720 SNX19 0.38 5.88 0.34 1.22e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4727027 0.635 rs12111923 chr7:148885877 G/A cg23583168 chr7:148888333 NA -0.85 -11.83 -0.59 3.34e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9814567 1.000 rs1863913 chr3:134200205 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.76 -0.33 2.28e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg18032046 chr6:28092343 ZSCAN16 -0.48 -6.22 -0.36 1.98e-9 Cardiac Troponin-T levels; CESC cis rs12950390 0.853 rs56387656 chr17:45860189 C/G cg00777063 chr17:45855553 NA -0.38 -5.68 -0.33 3.49e-8 IgG glycosylation; CESC cis rs7726839 0.540 rs72705102 chr5:659437 T/C cg16447950 chr5:562315 NA -0.61 -6.43 -0.37 5.93e-10 Obesity-related traits; CESC cis rs897984 0.647 rs8060857 chr16:31002720 G/A cg02466173 chr16:30829666 NA 0.48 7.93 0.44 6.03e-14 Dementia with Lewy bodies; CESC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg17724175 chr1:150552817 MCL1 0.36 5.46 0.32 1.08e-7 Melanoma; CESC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.97 0.34 7.51e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 0.900 rs10019460 chr4:17686337 T/C cg02297831 chr4:17616191 MED28 -0.48 -5.68 -0.33 3.59e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.04 0.4 1.67e-11 Height; CESC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg07308232 chr7:1071921 C7orf50 -0.6 -8.45 -0.46 1.94e-15 Longevity;Endometriosis; CESC cis rs137699 0.652 rs2413589 chr22:39755689 C/T cg05872129 chr22:39784769 NA 0.51 5.74 0.33 2.6e-8 IgG glycosylation; CESC cis rs11098499 0.818 rs55825515 chr4:120486402 A/G cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.26e-8 Corneal astigmatism; CESC cis rs460214 0.564 rs464519 chr21:40024182 A/G cg05519781 chr21:40033154 ERG -0.47 -6.06 -0.35 4.64e-9 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs10504229 0.679 rs11783557 chr8:58030644 A/G cg22535103 chr8:58192502 C8orf71 -0.57 -6.56 -0.37 2.78e-10 Developmental language disorder (linguistic errors); CESC cis rs8180040 0.654 rs1466740 chr3:47245883 C/T cg27129171 chr3:47204927 SETD2 -0.66 -9.64 -0.51 4.74e-19 Colorectal cancer; CESC cis rs4919687 0.550 rs17784294 chr10:104479385 G/T cg04362960 chr10:104952993 NT5C2 0.48 5.61 0.33 5e-8 Colorectal cancer; CESC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg00149659 chr3:10157352 C3orf10 0.76 9.49 0.5 1.43e-18 Alzheimer's disease; CESC cis rs208520 0.802 rs851600 chr6:66893754 T/C cg07460842 chr6:66804631 NA -0.93 -11.86 -0.59 2.64e-26 Exhaled nitric oxide output; CESC cis rs12477438 0.735 rs12474477 chr2:99690408 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.14e-23 Chronic sinus infection; CESC cis rs896543 0.702 rs12692189 chr2:237496112 A/G cg25295825 chr2:237489920 CXCR7 -0.72 -9.59 -0.51 6.83e-19 Alcohol dependence (age at onset); CESC cis rs2882667 0.858 rs7724108 chr5:138410922 A/G cg04439458 chr5:138467593 SIL1 0.39 6.12 0.35 3.27e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs15676 0.947 rs2977994 chr9:131585216 G/T cg00228799 chr9:131580591 ENDOG 0.45 5.66 0.33 4.03e-8 Blood metabolite levels; CESC cis rs12148488 0.763 rs2304902 chr15:75340727 G/T cg09165964 chr15:75287851 SCAMP5 0.61 8.15 0.45 1.41e-14 Caffeine consumption; CESC trans rs9853921 0.963 rs9881954 chr3:117896366 A/G cg19688222 chr4:4199452 OTOP1 -0.39 -6.08 -0.35 4.17e-9 JT interval (sulfonylurea treatment interaction); CESC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg06634786 chr22:41940651 POLR3H -0.66 -6.54 -0.37 3.13e-10 Vitiligo; CESC cis rs13266463 1.000 rs13266463 chr8:143403693 A/G cg16886403 chr8:143471632 TSNARE1 -0.47 -6.01 -0.35 6.27e-9 Schizophrenia; CESC cis rs1580019 0.523 rs13236410 chr7:32690663 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.04 17.86 0.74 2.19e-47 Cognitive ability; CESC cis rs2006771 0.836 rs7285777 chr22:31982241 C/G cg25791279 chr22:32026902 PISD -0.43 -5.07 -0.3 7.39e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs3740713 1.000 rs73438687 chr11:18459859 A/G cg23797887 chr11:18477753 LDHAL6A -0.53 -5.11 -0.3 6.1e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7843479 0.544 rs4872110 chr8:21784989 A/G cg17168535 chr8:21777572 XPO7 0.7 10.95 0.56 2.84e-23 Mean corpuscular volume; CESC cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.4 0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6545883 0.965 rs3771258 chr2:61764140 C/T cg15711740 chr2:61764176 XPO1 -0.44 -5.34 -0.31 1.95e-7 Tuberculosis; CESC cis rs6570726 0.935 rs447247 chr6:145812678 G/T cg23711669 chr6:146136114 FBXO30 0.83 12.23 0.6 1.41e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs9660992 0.590 rs1779411 chr1:205238530 C/T cg00857998 chr1:205179979 DSTYK 0.47 5.35 0.31 1.87e-7 Mean corpuscular volume;Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22087053 chr5:140751506 PCDHGA4;PCDHGB3;PCDHGA1;PCDHGA5;PCDHGB1;PCDHGA3;PCDHGA2;PCDHGB2 -0.53 -6.39 -0.37 7.43e-10 Gut microbiome composition (summer); CESC cis rs6912958 0.559 rs242270 chr6:88062190 C/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.34 -5.75 -0.33 2.49e-8 Monocyte percentage of white cells; CESC cis rs12142240 0.698 rs41294476 chr1:46818374 C/A cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs9905704 0.633 rs2680687 chr17:56491966 T/C cg12560992 chr17:57184187 TRIM37 0.6 5.67 0.33 3.76e-8 Testicular germ cell tumor; CESC cis rs7078219 0.505 rs10883373 chr10:101292484 G/A cg09788492 chr10:101292477 NKX2-3 0.34 6.41 0.37 6.45e-10 Dental caries; CESC cis rs11122272 0.732 rs2808605 chr1:231540187 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.47 -0.42 1.14e-12 Hemoglobin concentration; CESC cis rs7267979 0.527 rs6083891 chr20:25574272 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.7 -11.29 -0.57 2.15e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs4664308 0.806 rs4665162 chr2:161060184 A/G cg03641300 chr2:160917029 PLA2R1 -0.64 -9.5 -0.5 1.34e-18 Idiopathic membranous nephropathy; CESC cis rs3733585 0.699 rs6815001 chr4:9958662 G/C cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1413885 0.516 rs10158872 chr1:65836230 T/C cg14976592 chr1:65886160 LEPROT;LEPR 0.46 5.91 0.34 1.03e-8 Anticoagulant levels; CESC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg27286337 chr10:134555280 INPP5A 0.68 7.64 0.42 4.05e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg01802117 chr1:53393560 SCP2 -0.4 -5.13 -0.3 5.57e-7 Monocyte count; CESC cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg02935154 chr7:12443704 VWDE -0.57 -7.08 -0.4 1.29e-11 Coronary artery disease; CESC trans rs9929218 0.581 rs12185157 chr16:68784587 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.85 13.09 0.63 1.61e-30 Colorectal cancer; CESC cis rs17293817 0.958 rs12771141 chr10:1442709 A/G cg08482957 chr10:1437944 ADARB2 0.35 5.1 0.3 6.54e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs73001065 0.636 rs8182472 chr19:19539891 A/G cg03709012 chr19:19516395 GATAD2A 0.82 6.97 0.39 2.52e-11 LDL cholesterol; CESC cis rs7223966 1.000 rs8078862 chr17:61854068 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.73 0.38 1.06e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2230307 0.536 rs561119 chr1:100603891 G/A cg24955406 chr1:100503596 HIAT1 -0.49 -5.18 -0.3 4.29e-7 Carotid intima media thickness; CESC cis rs7714584 1.000 rs7734778 chr5:150256556 G/A cg22134413 chr5:150180641 NA 0.53 6.21 0.36 2.05e-9 Crohn's disease; CESC trans rs2727020 0.658 rs1851992 chr11:49438110 C/T cg03929089 chr4:120376271 NA -0.81 -12.55 -0.61 1.11e-28 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26102683 chr11:82904715 ANKRD42 -0.53 -7.13 -0.4 9.4e-12 Fibrinogen levels; CESC cis rs9660992 0.573 rs1172158 chr1:205208948 G/A cg00857998 chr1:205179979 DSTYK 0.56 6.88 0.39 4.29e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg11644478 chr21:40555479 PSMG1 -0.8 -11.95 -0.59 1.32e-26 Cognitive function; CESC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg26314531 chr2:26401878 FAM59B 0.56 5.99 0.35 6.95e-9 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs74051609 chr14:56171132 G/A cg01858014 chr14:56050164 KTN1 -0.75 -6.5 -0.37 3.96e-10 Putamen volume; CESC cis rs7680126 0.500 rs4640669 chr4:10145733 A/G cg00071950 chr4:10020882 SLC2A9 0.59 6.83 0.39 5.7e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1942 0.837 rs12440045 chr15:41782684 A/C cg18705301 chr15:41695430 NDUFAF1 -0.54 -7.73 -0.43 2.22e-13 Eosinophil percentage of granulocytes; CESC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.27 0.49 6.73e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg12564285 chr5:131593104 PDLIM4 0.38 5.8 0.34 1.92e-8 Acylcarnitine levels; CESC cis rs7267979 1.000 rs2259928 chr20:25281834 G/C cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs631288 0.557 rs920682 chr1:146657523 C/A cg25205988 chr1:146714368 CHD1L 1.04 6.66 0.38 1.58e-10 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg17366294 chr4:99064904 C4orf37 0.62 8.79 0.47 1.99e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9894429 0.966 rs6565604 chr17:79589242 G/A cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.98e-8 Eye color traits; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg22637730 chr3:160473554 PPM1L 0.48 6.08 0.35 4.21e-9 Retinol levels; CESC cis rs4253772 0.591 rs6008362 chr22:46652737 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.15 0.45 1.5e-14 LDL cholesterol;Cholesterol, total; CESC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg04772025 chr11:68637568 NA 0.55 6.14 0.35 2.95e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg18337363 chr3:52569053 NT5DC2 0.28 5.12 0.3 5.85e-7 Bipolar disorder; CESC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.28e-13 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10985647 chr6:150326596 RAET1K -0.71 -8.45 -0.46 1.96e-15 Gut microbiome composition (summer); CESC cis rs3126085 0.696 rs41266112 chr1:152185762 C/G cg26876637 chr1:152193138 HRNR 0.48 5.5 0.32 8.93e-8 Atopic dermatitis; CESC cis rs12477438 0.734 rs4851184 chr2:99666434 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs1878931 0.697 rs10048148 chr16:3417450 C/G cg22508957 chr16:3507546 NAT15 -0.4 -5.81 -0.34 1.77e-8 Body mass index (adult); CESC cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg04450456 chr4:17643702 FAM184B 0.39 5.63 0.33 4.55e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2120019 1.000 rs1867146 chr15:75354971 C/G cg17294928 chr15:75287854 SCAMP5 -0.65 -6.96 -0.39 2.66e-11 Blood trace element (Zn levels); CESC cis rs6964587 1.000 rs2282974 chr7:91761617 G/A cg17063962 chr7:91808500 NA 0.59 8.13 0.45 1.69e-14 Breast cancer; CESC cis rs17666538 0.642 rs7821983 chr8:643696 A/G cg13264159 chr8:625131 ERICH1 -0.61 -5.32 -0.31 2.21e-7 IgG glycosylation; CESC cis rs4629180 0.606 rs13390891 chr2:102111943 T/C cg04415270 chr2:102091202 RFX8 -0.31 -5.45 -0.32 1.18e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg08109568 chr15:31115862 NA -0.71 -9.44 -0.5 2.03e-18 Huntington's disease progression; CESC cis rs9611519 1.000 rs9611519 chr22:41613188 C/T cg03806693 chr22:41940476 POLR3H -0.62 -6.45 -0.37 5.16e-10 Neuroticism; CESC cis rs12893668 0.637 rs4525427 chr14:104072793 C/A cg08213375 chr14:104286397 PPP1R13B 0.33 5.16 0.3 4.79e-7 Reticulocyte count; CESC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg07308232 chr7:1071921 C7orf50 -0.58 -8.08 -0.44 2.36e-14 Longevity;Endometriosis; CESC cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg05313129 chr8:58192883 C8orf71 0.5 5.32 0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg23758822 chr17:41437982 NA 1.02 18.3 0.75 6.21e-49 Menopause (age at onset); CESC cis rs7267979 1.000 rs6050573 chr20:25366065 C/G cg08601574 chr20:25228251 PYGB 0.37 5.33 0.31 2.09e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs734999 0.566 rs6424092 chr1:2532899 C/A cg20673091 chr1:2541236 MMEL1 -0.44 -7.39 -0.41 1.95e-12 Ulcerative colitis; CESC cis rs7520050 0.966 rs11211199 chr1:46287869 T/C cg03146154 chr1:46216737 IPP -0.47 -6.15 -0.35 2.87e-9 Red blood cell count;Reticulocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19092721 chr12:122260723 SETD1B 0.42 6.06 0.35 4.74e-9 Fibrinogen levels; CESC cis rs4975616 0.836 rs421629 chr5:1320136 G/A cg06550200 chr5:1325588 CLPTM1L -0.69 -10.49 -0.54 9.55e-22 Lung cancer; CESC cis rs2404602 0.692 rs34478400 chr15:76923510 C/T cg26408565 chr15:76604113 ETFA -0.39 -5.51 -0.32 8.57e-8 Blood metabolite levels; CESC cis rs2274273 0.967 rs17832359 chr14:55615941 T/C cg04306507 chr14:55594613 LGALS3 0.29 5.41 0.32 1.44e-7 Protein biomarker; CESC cis rs6089584 0.627 rs35560719 chr20:60561917 A/C cg06108461 chr20:60628389 TAF4 -0.52 -6.87 -0.39 4.66e-11 Body mass index; CESC cis rs7772486 0.682 rs1337840 chr6:146042558 T/C cg23711669 chr6:146136114 FBXO30 -0.82 -12.04 -0.59 6.45e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.954 rs12508504 chr4:120410607 A/C cg24375607 chr4:120327624 NA 0.45 5.72 0.33 2.93e-8 Corneal astigmatism; CESC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg21770322 chr7:97807741 LMTK2 0.55 8.22 0.45 9.38e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs2806561 0.929 rs10917357 chr1:23535161 C/T cg12483005 chr1:23474871 LUZP1 0.33 5.24 0.31 3.25e-7 Height; CESC cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg14829155 chr15:31115871 NA 0.79 10.93 0.56 3.32e-23 Huntington's disease progression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15419313 chr20:3026568 MRPS26 0.53 6.08 0.35 4.16e-9 Gut microbiome composition (summer); CESC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.26 -0.36 1.54e-9 Total body bone mineral density; CESC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg10691866 chr7:65817282 TPST1 -0.35 -5.64 -0.33 4.46e-8 Aortic root size; CESC cis rs2380220 0.574 rs9400526 chr6:95998441 T/C cg15832292 chr6:96025679 MANEA 0.63 7.18 0.4 7.12e-12 Behavioural disinhibition (generation interaction); CESC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg27286337 chr10:134555280 INPP5A 0.61 6.98 0.39 2.31e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13896604 chr17:73043189 ATP5H;KCTD2 -0.43 -6.29 -0.36 1.3e-9 Gambling; CESC cis rs10949834 0.689 rs2269081 chr7:73519887 T/G cg07137043 chr7:73588983 EIF4H -0.68 -6.21 -0.36 1.99e-9 Verbal memory performance (residualized delayed recall change); CESC cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg25517755 chr10:38738941 LOC399744 -0.48 -6.23 -0.36 1.82e-9 Extrinsic epigenetic age acceleration; CESC cis rs16866061 1.000 rs11681451 chr2:225334104 T/C cg12698349 chr2:225449008 CUL3 0.71 10.62 0.55 3.56e-22 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs6714710 0.603 rs78006955 chr2:98455510 G/C cg26665480 chr2:98280029 ACTR1B 0.57 8.02 0.44 3.49e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs4720575 1.000 rs917108 chr7:47088047 A/G cg00036614 chr7:47093842 NA -0.42 -6.53 -0.37 3.3e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs6582630 0.519 rs11495700 chr12:38288240 A/G cg26384229 chr12:38710491 ALG10B 0.73 10.52 0.54 7.46e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs9399135 1.000 rs6569988 chr6:135352303 C/A cg24558204 chr6:135376177 HBS1L 0.49 6.72 0.38 1.09e-10 Red blood cell count; CESC cis rs7000551 0.619 rs2443506 chr8:22373383 T/C cg12081754 chr8:22256438 SLC39A14 0.39 5.31 0.31 2.34e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs2066819 1.000 rs74496027 chr12:56726340 C/T cg26714650 chr12:56694279 CS -1.39 -9.17 -0.49 1.33e-17 Psoriasis vulgaris; CESC cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg00255919 chr5:131827918 IRF1 0.51 8.59 0.47 7.76e-16 Asthma (sex interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14012233 chr17:27276799 PHF12 -0.49 -6.8 -0.39 6.9e-11 Fibrinogen levels; CESC cis rs4268898 0.610 rs55860688 chr2:24451534 T/C cg06627628 chr2:24431161 ITSN2 -0.99 -11.27 -0.57 2.58e-24 Asthma; CESC cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg20476274 chr7:133979776 SLC35B4 0.64 9.27 0.49 6.83e-18 Mean platelet volume; CESC cis rs10751667 0.666 rs7394958 chr11:965944 C/G cg06064525 chr11:970664 AP2A2 -0.48 -9.29 -0.5 5.99e-18 Alzheimer's disease (late onset); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg09233161 chr9:37079712 NA -0.45 -6.7 -0.38 1.24e-10 Vertical cup-disc ratio; CESC cis rs2302190 0.882 rs8072873 chr17:56669049 G/C cg25885038 chr17:56607967 SEPT4 -0.4 -5.43 -0.32 1.27e-7 Vitamin D levels; CESC cis rs7631605 0.544 rs61493618 chr3:37173775 A/T cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.23 -0.31 3.44e-7 Cerebrospinal P-tau181p levels; CESC cis rs1153858 1.000 rs2461701 chr15:45703391 G/A cg10760299 chr15:45669010 GATM 0.37 5.14 0.3 5.43e-7 Homoarginine levels; CESC cis rs3105593 1.000 rs3109888 chr15:50860694 C/A cg08437265 chr15:50716283 USP8 0.4 5.21 0.3 3.84e-7 QT interval; CESC cis rs56346965 0.967 rs11900804 chr2:191533767 T/C cg27211696 chr2:191398769 TMEM194B -0.42 -5.57 -0.32 6.32e-8 Bone mineral density (Ward's triangle area); CESC cis rs9549367 0.756 rs3861723 chr13:113910926 A/G cg00898013 chr13:113819073 PROZ -0.49 -7.12 -0.4 1e-11 Platelet distribution width; CESC cis rs10911251 0.528 rs10911266 chr1:183115097 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 13.8 0.65 5.11e-33 Colorectal cancer; CESC cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg07636037 chr3:49044803 WDR6 1.02 18.99 0.76 2.3e-51 Parkinson's disease; CESC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg00166722 chr3:10149974 C3orf24 0.46 5.89 0.34 1.18e-8 Alzheimer's disease; CESC cis rs10089 0.953 rs1985268 chr5:127375931 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.15 0.53 1.14e-20 Ileal carcinoids; CESC cis rs5757676 1.000 rs5757676 chr22:39841700 T/C cg01416388 chr22:39784598 NA -0.65 -6.78 -0.38 7.71e-11 IgG glycosylation; CESC cis rs2180341 0.960 rs1964130 chr6:127677391 C/G cg24812749 chr6:127587940 RNF146 0.97 13.04 0.63 2.4e-30 Breast cancer; CESC cis rs3126085 1.000 rs2338555 chr1:152309380 G/A cg03465714 chr1:152285911 FLG 0.43 5.22 0.31 3.62e-7 Atopic dermatitis; CESC cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg15506890 chr2:3487001 NA -0.52 -6.69 -0.38 1.32e-10 Neurofibrillary tangles; CESC cis rs17655565 0.581 rs1622677 chr12:52762444 A/G cg00777198 chr12:52828273 KRT75 -0.38 -5.62 -0.33 4.95e-8 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.27 -0.31 2.86e-7 Total body bone mineral density; CESC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg22535103 chr8:58192502 C8orf71 -1.05 -12.93 -0.62 5.44e-30 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg23978390 chr7:1156363 C7orf50 0.59 8.05 0.44 2.77e-14 Longevity;Endometriosis; CESC cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 5.82 0.34 1.71e-8 Personality dimensions; CESC cis rs7208859 0.614 rs216412 chr17:28903394 A/G cg17105886 chr17:28927953 LRRC37B2 -0.63 -5.95 -0.34 8.28e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4561483 0.645 rs2192645 chr16:11928019 C/T cg08843971 chr16:11963173 GSPT1 -0.47 -6.6 -0.38 2.28e-10 Testicular germ cell tumor; CESC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg03351412 chr1:154909251 PMVK -0.68 -9.41 -0.5 2.47e-18 Prostate cancer; CESC cis rs7264396 0.747 rs2425158 chr20:34419664 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -11.28 -0.57 2.4e-24 Total cholesterol levels; CESC cis rs425277 0.606 rs3128295 chr1:2068480 C/T cg19257562 chr1:2043853 PRKCZ 0.34 5.33 0.31 2.13e-7 Height; CESC cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg05347473 chr6:146136440 FBXO30 -0.59 -7.61 -0.42 4.8e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs524281 0.692 rs2302884 chr11:65824084 C/T cg14036092 chr11:66035641 RAB1B -0.58 -6.32 -0.36 1.08e-9 Electroencephalogram traits; CESC cis rs6963495 0.818 rs73190181 chr7:105162907 A/C cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs7130144 0.541 rs28402217 chr11:130459644 C/G cg26307797 chr11:130446613 NA -0.74 -6.36 -0.36 8.72e-10 Urate levels in lean individuals; CESC cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg10523679 chr1:76189770 ACADM 0.8 10.96 0.56 2.71e-23 Blood metabolite levels;Acylcarnitine levels; CESC cis rs13102973 1.000 rs7439938 chr4:135897696 G/A cg14419869 chr4:135874104 NA -0.36 -5.41 -0.32 1.38e-7 Subjective well-being; CESC cis rs7917772 0.503 rs746552 chr10:104342501 A/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.94e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1559088 0.895 rs13345542 chr19:33586739 G/C cg17764715 chr19:33622953 WDR88 0.49 6.32 0.36 1.11e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6460942 0.591 rs6942432 chr7:12338393 A/G cg20607287 chr7:12443886 VWDE -0.59 -6.52 -0.37 3.45e-10 Coronary artery disease; CESC cis rs9790314 1.000 rs459697 chr3:161093420 G/A cg03342759 chr3:160939853 NMD3 -0.48 -6.04 -0.35 5.32e-9 Morning vs. evening chronotype; CESC cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg15485101 chr11:133734466 NA 0.41 6.54 0.37 3.09e-10 Childhood ear infection; CESC cis rs7119 0.717 rs11632729 chr15:77722006 G/A cg17802220 chr15:77601643 NA -0.5 -6.97 -0.39 2.51e-11 Type 2 diabetes; CESC cis rs34524635 1 rs34524635 chr10:65261176 CT/C cg01631684 chr10:65280961 REEP3 -0.45 -5.63 -0.33 4.59e-8 Vascular endothelial growth factor levels; CESC cis rs72781680 0.898 rs55841168 chr2:24007926 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23239052 chr17:79008930 FLJ90757;BAIAP2 0.65 7.93 0.44 6.01e-14 Gut microbiome composition (summer); CESC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg27266027 chr21:40555129 PSMG1 0.44 5.25 0.31 3.16e-7 Cognitive function; CESC trans rs7120489 0.748 rs57628814 chr11:12456399 G/A cg05526731 chr17:185263 RPH3AL 0.8 6.06 0.35 4.69e-9 Mortality in heart failure; CESC cis rs2599510 0.729 rs1135484 chr2:32749060 G/A cg02381751 chr2:32503542 YIPF4 0.48 5.87 0.34 1.27e-8 Interleukin-18 levels; CESC cis rs3815700 1.000 rs8104726 chr19:33094675 G/A cg24916020 chr19:33096688 ANKRD27 0.59 5.75 0.33 2.5e-8 Eosinophilic esophagitis; CESC cis rs2795502 0.882 rs2744095 chr10:43337949 A/T cg27426351 chr10:43362370 NA -0.44 -5.45 -0.32 1.17e-7 Blood protein levels; CESC cis rs2180341 1.000 rs6569482 chr6:127631371 C/T cg27446573 chr6:127587934 RNF146 1.09 16.33 0.71 5.73e-42 Breast cancer; CESC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.92e-8 Lung cancer; CESC cis rs56399783 0.708 rs56208415 chr7:2813806 G/A cg19731401 chr7:2775893 GNA12 0.65 5.95 0.34 8.4e-9 Childhood ear infection; CESC cis rs6570726 0.846 rs4896824 chr6:145927048 C/T cg05347473 chr6:146136440 FBXO30 0.48 6.39 0.37 7.61e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs11608355 0.515 rs11611011 chr12:109936948 C/T cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs1355223 0.902 rs836462 chr11:34743263 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.44 -0.37 5.45e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs727505 0.789 rs9641761 chr7:124735205 A/T cg23710748 chr7:124431027 NA -0.4 -6.5 -0.37 4.07e-10 Lewy body disease; CESC cis rs12464483 0.591 rs4952171 chr2:30886903 G/A cg12454169 chr2:30669597 LCLAT1 0.64 6.32 0.36 1.13e-9 Pre-treatment pain in head and neck squamous cell carcinoma; CESC cis rs6500395 1.000 rs1120276 chr16:48598517 C/G cg04672837 chr16:48644449 N4BP1 0.5 6.12 0.35 3.33e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg03929089 chr4:120376271 NA -0.52 -6.02 -0.35 5.81e-9 HDL cholesterol; CESC cis rs863345 0.604 rs2873594 chr1:158504790 T/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg21963583 chr11:68658836 MRPL21 0.4 5.79 0.34 1.96e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg12463550 chr7:65579703 CRCP 0.54 6.7 0.38 1.25e-10 Aortic root size; CESC cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg24110177 chr3:50126178 RBM5 0.57 7.98 0.44 4.45e-14 Body mass index; CESC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.49 -0.37 4.23e-10 Parkinson's disease; CESC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg07308232 chr7:1071921 C7orf50 -0.61 -8.59 -0.47 7.45e-16 Longevity;Endometriosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06785624 chr8:144990484 PLEC1 0.47 6.13 0.35 3.21e-9 Fibrinogen levels; CESC cis rs7640424 0.620 rs17231503 chr3:107817299 C/T cg09227934 chr3:107805635 CD47 -0.46 -5.64 -0.33 4.44e-8 Body mass index; CESC cis rs8072100 0.967 rs8074149 chr17:45583375 A/C cg08085267 chr17:45401833 C17orf57 0.43 5.64 0.33 4.28e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2637266 0.597 rs2583065 chr10:78555915 A/G cg18941641 chr10:78392320 NA 0.41 7.79 0.43 1.51e-13 Pulmonary function; CESC cis rs5758659 1.000 rs134869 chr22:42652074 G/A cg05082376 chr22:42548792 NA -0.39 -5.84 -0.34 1.55e-8 Cognitive function; CESC cis rs13202913 0.837 rs9397054 chr6:151789912 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.65 5.08 0.3 7.08e-7 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs1707322 0.785 rs10890348 chr1:46242423 G/T cg05343316 chr1:45956843 TESK2 0.48 5.84 0.34 1.53e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg26597838 chr10:835615 NA 0.86 8.93 0.48 7.33e-17 Eosinophil percentage of granulocytes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12626377 chr20:34330591 RBM39 -0.5 -6.66 -0.38 1.58e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7659604 0.540 rs9998385 chr4:122676673 C/T cg19671926 chr4:122722719 EXOSC9 0.53 6.7 0.38 1.21e-10 Type 2 diabetes; CESC cis rs35955747 0.902 rs7288643 chr22:31679669 C/A cg25791279 chr22:32026902 PISD -0.5 -6.0 -0.35 6.61e-9 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs7084402 0.905 rs1649031 chr10:60279742 G/A cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC cis rs748404 0.697 rs471122 chr15:43558574 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.5 -7.51 -0.42 8.96e-13 Lung cancer; CESC cis rs9790314 1.000 rs336591 chr3:161078080 A/G cg04691961 chr3:161091175 C3orf57 -0.41 -5.3 -0.31 2.44e-7 Morning vs. evening chronotype; CESC cis rs758324 0.606 rs247276 chr5:131469004 C/T cg20547724 chr5:131607888 PDLIM4 0.41 5.16 0.3 4.89e-7 Alzheimer's disease in APOE e4- carriers; CESC cis rs9926296 0.656 rs2376882 chr16:89827002 T/C cg27121462 chr16:89883253 FANCA 0.54 6.79 0.39 7.27e-11 Vitiligo; CESC cis rs9303401 0.659 rs12940212 chr17:56674474 T/C cg02118635 chr17:56770003 RAD51C;TEX14 1.0 11.47 0.58 5.4e-25 Cognitive test performance; CESC cis rs1348850 0.793 rs13027299 chr2:178455501 T/G cg23306229 chr2:178417860 TTC30B 0.44 5.35 0.31 1.87e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg23711669 chr6:146136114 FBXO30 1.01 15.52 0.69 4.59e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg25319279 chr11:5960081 NA -0.42 -5.92 -0.34 9.78e-9 DNA methylation (variation); CESC cis rs9393777 0.623 rs9358946 chr6:26478927 G/A cg14345882 chr6:26364793 BTN3A2 0.43 5.34 0.31 2.01e-7 Intelligence (multi-trait analysis); CESC cis rs2486288 0.656 rs8039138 chr15:45551592 C/T cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg04369109 chr6:150039330 LATS1 -0.41 -5.81 -0.34 1.82e-8 Lung cancer; CESC cis rs2066819 1.000 rs77768890 chr12:56725121 A/G cg26714650 chr12:56694279 CS -1.47 -9.75 -0.51 2.09e-19 Psoriasis vulgaris; CESC trans rs4332037 0.586 rs62442944 chr7:2015047 T/G cg11693508 chr17:37793320 STARD3 0.66 6.62 0.38 2.01e-10 Bipolar disorder; CESC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.66 -8.85 -0.48 1.24e-16 Prudent dietary pattern; CESC cis rs10751667 0.666 rs4072741 chr11:976565 T/C cg06064525 chr11:970664 AP2A2 -0.46 -8.93 -0.48 7.1e-17 Alzheimer's disease (late onset); CESC cis rs7927592 0.913 rs12363722 chr11:68236291 A/C cg20283391 chr11:68216788 NA -0.61 -7.29 -0.41 3.64e-12 Total body bone mineral density; CESC cis rs910316 0.503 rs4903273 chr14:75441795 G/A cg11812906 chr14:75593930 NEK9 -0.63 -8.94 -0.48 6.78e-17 Height; CESC cis rs11098499 0.954 rs1022145 chr4:120230979 A/G cg09307838 chr4:120376055 NA 0.93 12.78 0.62 1.83e-29 Corneal astigmatism; CESC cis rs9300255 0.508 rs1716176 chr12:123655467 T/G cg19016782 chr12:123741754 C12orf65 -0.45 -6.34 -0.36 9.76e-10 Neutrophil percentage of white cells; CESC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg12419862 chr22:24373484 LOC391322 -0.7 -9.66 -0.51 4.09e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2797160 1.000 rs2797161 chr6:126010789 A/G cg05901451 chr6:126070800 HEY2 0.47 6.85 0.39 5.01e-11 Endometrial cancer; CESC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg21770322 chr7:97807741 LMTK2 0.53 8.04 0.44 2.97e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg24110177 chr3:50126178 RBM5 -0.54 -7.55 -0.42 7.08e-13 Intelligence (multi-trait analysis); CESC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg20887711 chr4:1340912 KIAA1530 0.87 11.48 0.58 4.82e-25 Longevity; CESC cis rs7095944 0.584 rs4962693 chr10:126424835 C/T cg08799069 chr10:126477246 METTL10 -0.39 -5.55 -0.32 6.81e-8 Asthma; CESC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg06505273 chr16:24850292 NA 0.52 5.92 0.34 9.94e-9 Intelligence (multi-trait analysis); CESC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg26408565 chr15:76604113 ETFA -0.41 -6.07 -0.35 4.43e-9 Blood metabolite levels; CESC cis rs7553864 0.605 rs7531038 chr1:87605049 C/G cg17420885 chr1:87600446 LOC339524 -0.42 -5.67 -0.33 3.7e-8 Smoking behavior; CESC cis rs1348850 0.634 rs1534304 chr2:178489264 C/T cg23306229 chr2:178417860 TTC30B 0.55 6.16 0.35 2.69e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs28489187 0.706 rs233060 chr1:85798943 C/T cg16011679 chr1:85725395 C1orf52 0.48 5.68 0.33 3.58e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs11792861 0.781 rs72607159 chr9:111764270 C/T cg05043794 chr9:111880884 C9orf5 -0.36 -5.81 -0.34 1.76e-8 Menarche (age at onset); CESC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.89 0.34 1.19e-8 Tonsillectomy; CESC cis rs727563 0.565 rs132774 chr22:42031953 C/G cg17376030 chr22:41985996 PMM1 0.48 5.56 0.32 6.72e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs7078219 0.505 rs7908704 chr10:101293318 G/A cg09788492 chr10:101292477 NKX2-3 0.32 5.99 0.35 6.65e-9 Dental caries; CESC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg05368731 chr17:41323189 NBR1 0.8 11.32 0.57 1.66e-24 Menopause (age at onset); CESC cis rs9911578 0.967 rs8082544 chr17:57185807 C/T cg12560992 chr17:57184187 TRIM37 -1.0 -17.6 -0.73 1.9e-46 Intelligence (multi-trait analysis); CESC cis rs11077998 0.967 rs12185229 chr17:80499065 G/C cg10255544 chr17:80519551 FOXK2 0.55 8.85 0.48 1.27e-16 Reticulocyte fraction of red cells; CESC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg09365446 chr1:150670422 GOLPH3L -0.38 -5.08 -0.3 6.97e-7 Melanoma; CESC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg17971929 chr21:40555470 PSMG1 1.05 16.19 0.71 1.86e-41 Cognitive function; CESC cis rs34779708 0.931 rs2244100 chr10:35323636 G/A cg04310649 chr10:35416472 CREM 0.5 6.19 0.36 2.28e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs41563 0.674 rs2192932 chr7:104653265 A/G cg04380332 chr7:105027541 SRPK2 0.38 5.46 0.32 1.12e-7 Autism spectrum disorder or schizophrenia; CESC cis rs10504229 0.679 rs16921677 chr8:58052431 T/C cg22535103 chr8:58192502 C8orf71 -0.66 -7.26 -0.41 4.29e-12 Developmental language disorder (linguistic errors); CESC cis rs11792861 0.816 rs3763643 chr9:111695607 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 6.7 0.38 1.21e-10 Menarche (age at onset); CESC cis rs7208859 0.673 rs9898858 chr17:29156211 A/T cg19761014 chr17:28927070 LRRC37B2 0.74 6.03 0.35 5.43e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7949030 0.588 rs2512563 chr11:62311249 C/G cg02375832 chr11:62437615 C11orf48 -0.36 -5.34 -0.31 1.98e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg15605315 chr1:45957053 TESK2 0.47 6.18 0.35 2.42e-9 High light scatter reticulocyte count; CESC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg03452623 chr4:187889614 NA -0.86 -14.21 -0.66 1.82e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg07677032 chr17:61819896 STRADA 0.46 6.1 0.35 3.83e-9 Prudent dietary pattern; CESC cis rs34779708 0.931 rs7920095 chr10:35303334 G/A cg04310649 chr10:35416472 CREM -0.5 -5.98 -0.34 7.34e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs17253792 0.822 rs76205307 chr14:56166038 C/T cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs4974559 0.947 rs12639938 chr4:1343135 G/C cg02980000 chr4:1222292 CTBP1 0.68 6.25 0.36 1.6e-9 Systolic blood pressure; CESC cis rs36051895 0.659 rs3780365 chr9:5068520 T/C cg02405213 chr9:5042618 JAK2 -0.48 -5.91 -0.34 1.06e-8 Pediatric autoimmune diseases; CESC cis rs2288073 0.801 rs72797831 chr2:24366829 G/A cg20701182 chr2:24300061 SF3B14 0.45 5.47 0.32 1.04e-7 Venous thromboembolism (SNP x SNP interaction); CESC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.43 0.32 1.25e-7 Bipolar disorder; CESC cis rs9768139 0.935 rs10949715 chr7:158117246 G/T cg06219351 chr7:158114137 PTPRN2 -0.45 -7.22 -0.41 5.61e-12 Calcium levels; CESC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.08 11.71 0.58 8.24e-26 Gut microbiome composition (summer); CESC cis rs644799 0.965 rs2508713 chr11:95547927 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.91 13.69 0.64 1.25e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs13098911 0.540 rs35772789 chr3:46095104 A/G cg10236987 chr1:228114221 WNT9A 0.63 6.2 0.36 2.12e-9 Celiac disease; CESC cis rs1034435 0.547 rs5768686 chr22:48899214 G/A cg05992904 chr22:48892994 FAM19A5 -0.45 -6.67 -0.38 1.48e-10 Late-onset Alzheimer's disease; CESC cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg05283184 chr6:79620031 NA -0.41 -6.41 -0.37 6.48e-10 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs17384381 1.000 rs12128907 chr1:85891385 A/G cg16011679 chr1:85725395 C1orf52 0.74 7.65 0.43 3.82e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs57221529 0.599 rs72707027 chr5:671294 C/G cg16447950 chr5:562315 NA -0.67 -7.03 -0.4 1.75e-11 Lung disease severity in cystic fibrosis; CESC cis rs2635047 0.756 rs34939493 chr18:44795621 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.33 0.31 2.1e-7 Educational attainment; CESC cis rs1707322 1.000 rs10158032 chr1:46332701 T/C cg03146154 chr1:46216737 IPP 0.72 9.9 0.52 7.12e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg03060546 chr3:49711283 APEH 0.45 5.63 0.33 4.6e-8 Parkinson's disease; CESC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg07167872 chr1:205819463 PM20D1 0.44 6.27 0.36 1.49e-9 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs7247513 0.759 rs8110545 chr19:12754898 C/T cg06417478 chr19:12876846 HOOK2 0.43 5.3 0.31 2.47e-7 Bipolar disorder; CESC trans rs7103648 0.553 rs12803857 chr11:47890172 G/A cg15704280 chr7:45808275 SEPT13 -0.53 -6.24 -0.36 1.69e-9 Diastolic blood pressure;Systolic blood pressure; CESC cis rs9372253 1.000 rs9372253 chr6:110716136 C/T cg19196401 chr6:110721138 DDO -0.39 -5.65 -0.33 4.21e-8 Platelet distribution width; CESC cis rs4629710 0.592 rs35017713 chr6:131581212 G/A cg12606694 chr6:131520996 AKAP7 0.48 5.82 0.34 1.68e-8 Multiple myeloma (IgH translocation); CESC cis rs6500602 0.893 rs934888 chr16:4462832 C/T cg08645402 chr16:4508243 NA 0.38 5.38 0.31 1.68e-7 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25104118 chr12:125621344 AACS 0.47 6.52 0.37 3.45e-10 Fibrinogen levels; CESC cis rs9039 1.000 rs1128001 chr16:9207003 T/C cg08831531 chr16:9218945 NA -0.43 -6.01 -0.35 6.23e-9 Menopause (age at onset); CESC cis rs116095464 0.558 rs28729548 chr5:229025 C/T cg10591111 chr5:226296 SDHA -0.54 -6.65 -0.38 1.72e-10 Breast cancer; CESC cis rs2304069 0.909 rs8073 chr5:149362400 T/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.87 -10.57 -0.54 5.16e-22 HIV-1 control; CESC cis rs2239547 0.522 rs7652131 chr3:52997154 C/T cg11645453 chr3:52864694 ITIH4 0.33 5.64 0.33 4.37e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00758816 chr15:69843549 NA -0.53 -6.24 -0.36 1.7e-9 Gut microbiome composition (summer); CESC cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg19729930 chr2:74357872 NA 0.84 12.54 0.61 1.2e-28 Gestational age at birth (maternal effect); CESC cis rs11166629 1.000 rs6992668 chr8:135645129 T/C cg21672855 chr8:135614777 ZFAT 0.4 5.09 0.3 6.9e-7 Smoking quantity; CESC cis rs1707322 1.000 rs7547189 chr1:46319514 C/A cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs963731 0.649 rs2123881 chr2:39247742 G/A cg04010122 chr2:39346883 SOS1 -0.73 -5.39 -0.31 1.54e-7 Corticobasal degeneration; CESC cis rs698833 0.798 rs1067391 chr2:44639434 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 6.61 0.38 2.16e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23709117 chr6:108882119 FOXO3 0.54 6.12 0.35 3.27e-9 Gut microbiome composition (summer); CESC cis rs2404602 0.716 rs4886813 chr15:76838221 C/T cg26408565 chr15:76604113 ETFA 0.4 5.98 0.34 7.24e-9 Blood metabolite levels; CESC cis rs10484885 0.793 rs1465954 chr6:90475013 G/A cg13799429 chr6:90582589 CASP8AP2 0.7 7.94 0.44 5.6e-14 QRS interval (sulfonylurea treatment interaction); CESC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.06e-7 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06434972 chr7:44122219 POLM 0.51 6.62 0.38 1.93e-10 Gut microbiota (bacterial taxa); CESC cis rs6963495 0.745 rs73192152 chr7:105212258 A/C cg13798780 chr7:105162888 PUS7 0.77 7.56 0.42 6.63e-13 Bipolar disorder (body mass index interaction); CESC trans rs61931739 0.500 rs7311284 chr12:34478477 C/G cg13010199 chr12:38710504 ALG10B 0.5 6.47 0.37 4.76e-10 Morning vs. evening chronotype; CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg23131131 chr22:24373011 LOC391322 -0.66 -9.03 -0.49 3.54e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4718428 0.705 rs4717328 chr7:66352665 T/C cg12165864 chr7:66369176 NA -0.65 -7.39 -0.41 1.87e-12 Corneal structure; CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg27094323 chr7:1216898 NA -0.42 -5.8 -0.34 1.93e-8 Longevity;Endometriosis; CESC cis rs6121246 0.529 rs58757492 chr20:30181425 G/A cg13852791 chr20:30311386 BCL2L1 0.57 5.5 0.32 9.14e-8 Mean corpuscular hemoglobin; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11698548 chr7:43769233 C7orf44 -0.44 -6.02 -0.35 5.85e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs950169 0.887 rs3860265 chr15:84945185 C/T cg17507749 chr15:85114479 UBE2QP1 0.59 6.52 0.37 3.46e-10 Schizophrenia; CESC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg07677032 chr17:61819896 STRADA 0.44 6.05 0.35 4.85e-9 Prudent dietary pattern; CESC cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg17211192 chr8:82754475 SNX16 -0.69 -8.22 -0.45 9.26e-15 Diastolic blood pressure; CESC cis rs6456156 0.526 rs1854853 chr6:167533062 A/G cg07741184 chr6:167504864 NA -0.32 -5.49 -0.32 9.52e-8 Primary biliary cholangitis; CESC cis rs4132509 0.779 rs3006939 chr1:243677834 G/A cg21452805 chr1:244014465 NA 0.41 5.1 0.3 6.55e-7 RR interval (heart rate); CESC cis rs8092503 1.000 rs12454204 chr18:52500011 G/T cg12377874 chr18:52495404 RAB27B 0.4 6.06 0.35 4.56e-9 Childhood body mass index; CESC cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.79 8.31 0.45 5.17e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs5758659 0.504 rs133367 chr22:42463366 A/G cg04733989 chr22:42467013 NAGA -0.59 -8.79 -0.48 1.92e-16 Cognitive function; CESC cis rs2404602 0.692 rs57178708 chr15:76904069 T/C cg26408565 chr15:76604113 ETFA -0.4 -5.73 -0.33 2.68e-8 Blood metabolite levels; CESC cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg25985355 chr7:65971099 NA 0.31 5.13 0.3 5.64e-7 Aortic root size; CESC cis rs6088590 1.000 rs6120747 chr20:33449769 T/C cg24642439 chr20:33292090 TP53INP2 0.86 11.97 0.59 1.12e-26 Coronary artery disease; CESC cis rs597539 0.521 rs2060982 chr11:68612927 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.4 5.14 0.3 5.29e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7520050 1.000 rs12143096 chr1:46469763 G/A cg03146154 chr1:46216737 IPP -0.46 -5.87 -0.34 1.31e-8 Red blood cell count;Reticulocyte count; CESC cis rs6460942 0.915 rs7803056 chr7:12306913 A/C cg20607287 chr7:12443886 VWDE -0.49 -6.77 -0.38 8.08e-11 Coronary artery disease; CESC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg04772025 chr11:68637568 NA 0.5 6.06 0.35 4.71e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2985684 0.901 rs2354448 chr14:50098296 G/A cg15316458 chr14:50087796 RPL36AL;MGAT2 0.45 5.15 0.3 4.99e-7 Carotid intima media thickness; CESC cis rs7119 0.717 rs12898281 chr15:77786903 C/T cg17802220 chr15:77601643 NA 0.49 6.77 0.38 8.28e-11 Type 2 diabetes; CESC cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.548 rs2320740 chr12:38166421 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.46 0.54 1.18e-21 Bladder cancer; CESC cis rs7160336 0.568 rs10146294 chr14:74681382 A/G cg08255017 chr14:74727001 VSX2 -0.38 -5.53 -0.32 7.71e-8 Blood protein levels; CESC cis rs9287719 0.934 rs10201077 chr2:10752426 A/C cg02196655 chr2:10830764 NOL10 -0.37 -5.68 -0.33 3.54e-8 Prostate cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21656748 chr4:77135347 SCARB2 -0.47 -6.32 -0.36 1.12e-9 Asthma; CESC cis rs559928 0.593 rs112275221 chr11:63936994 C/T cg18225595 chr11:63971243 STIP1 0.74 6.28 0.36 1.39e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs2439831 0.867 rs935901 chr15:43651256 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.92 9.25 0.49 7.78e-18 Lung cancer in ever smokers; CESC cis rs3087591 0.960 rs2905872 chr17:29525027 C/A cg24425628 chr17:29625626 OMG;NF1 0.44 5.55 0.32 7.1e-8 Hip circumference; CESC trans rs11098499 0.866 rs7677068 chr4:120291704 C/T cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs9399401 0.710 rs10484733 chr6:142710988 C/G cg03128060 chr6:142623767 GPR126 0.39 6.4 0.37 6.94e-10 Chronic obstructive pulmonary disease; CESC cis rs1878931 0.545 rs28603 chr16:3449479 A/G cg22508957 chr16:3507546 NAT15 0.5 6.52 0.37 3.55e-10 Body mass index (adult); CESC cis rs4843747 0.636 rs11864872 chr16:88105966 A/G cg17633681 chr16:88106987 BANP 0.76 10.42 0.54 1.55e-21 Menopause (age at onset); CESC cis rs4835473 0.615 rs6857432 chr4:144893065 C/G cg25736465 chr4:144833511 NA 0.39 5.97 0.34 7.43e-9 Immature fraction of reticulocytes; CESC cis rs6747952 0.899 rs1374387 chr2:239085687 A/C cg17459225 chr2:239074497 NA 0.33 5.34 0.31 1.96e-7 Mean corpuscular hemoglobin concentration; CESC cis rs6558174 0.965 rs7831119 chr8:22489678 C/T cg03733263 chr8:22462867 KIAA1967 -0.47 -6.34 -0.36 9.91e-10 Breast cancer; CESC cis rs4919694 0.611 rs75182663 chr10:105058104 A/G cg04362960 chr10:104952993 NT5C2 0.68 5.65 0.33 4.11e-8 Arsenic metabolism; CESC cis rs78456975 0.943 rs13385274 chr2:1576791 A/T cg26248373 chr2:1572462 NA -0.52 -5.11 -0.3 6.08e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs6120849 0.901 rs6088733 chr20:33744904 A/G cg24642439 chr20:33292090 TP53INP2 0.58 6.27 0.36 1.49e-9 Protein C levels; CESC cis rs7727544 0.660 rs274563 chr5:131717859 C/A cg24060327 chr5:131705240 SLC22A5 0.63 8.45 0.46 1.99e-15 Blood metabolite levels; CESC cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg26597838 chr10:835615 NA 0.86 9.04 0.49 3.46e-17 Eosinophil percentage of granulocytes; CESC cis rs898097 0.801 rs68141193 chr17:80878816 C/T cg10494973 chr17:80897199 TBCD 0.45 5.27 0.31 2.8e-7 Breast cancer; CESC cis rs854765 0.533 rs2955354 chr17:17948716 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.81 -0.48 1.7e-16 Total body bone mineral density; CESC cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg17366294 chr4:99064904 C4orf37 0.59 7.68 0.43 3.1400000000000003e-13 Colonoscopy-negative controls vs population controls; CESC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg00339695 chr16:24857497 SLC5A11 0.5 6.53 0.37 3.25e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg18337363 chr3:52569053 NT5DC2 -0.29 -5.44 -0.32 1.23e-7 Bipolar disorder; CESC cis rs6964587 0.626 rs34404183 chr7:91551249 T/C cg17063962 chr7:91808500 NA -0.45 -6.29 -0.36 1.29e-9 Breast cancer; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg02624704 chr1:173446429 PRDX6 -0.42 -6.5 -0.37 3.96e-10 Breast cancer; CESC cis rs4906332 0.933 rs34606394 chr14:103915636 G/A cg09975044 chr14:104007538 NA 0.47 6.53 0.37 3.32e-10 Coronary artery disease; CESC cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.56 -0.42 6.59e-13 Alzheimer's disease; CESC cis rs6460942 1.000 rs6970095 chr7:12403840 G/A cg02935154 chr7:12443704 VWDE -0.56 -6.1 -0.35 3.8e-9 Coronary artery disease; CESC cis rs921968 0.643 rs537520 chr2:219381852 A/G cg02176678 chr2:219576539 TTLL4 0.42 7.31 0.41 3.16e-12 Mean corpuscular hemoglobin concentration; CESC cis rs753778 0.570 rs10875465 chr8:142210500 A/G cg18755752 chr8:142205143 DENND3 -0.63 -9.24 -0.49 8.39e-18 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23214207 chr17:18476059 NA -0.67 -7.92 -0.44 6.59e-14 Gut microbiome composition (summer); CESC cis rs12422267 0.536 rs7976530 chr12:132609140 C/T cg09764611 chr12:132620959 NA -0.51 -6.61 -0.38 2.15e-10 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs9837602 0.507 rs1718244 chr3:99512608 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -5.91 -0.34 1.02e-8 Breast cancer; CESC cis rs6912958 0.712 rs4498321 chr6:88339251 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.24 -0.31 3.32e-7 Monocyte percentage of white cells; CESC cis rs4268898 0.662 rs72793967 chr2:24422902 C/T cg08917208 chr2:24149416 ATAD2B 0.55 5.31 0.31 2.27e-7 Asthma; CESC cis rs7833986 0.501 rs2953897 chr8:56980569 C/T cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.16 0.3 4.9e-7 Height; CESC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg15595755 chr5:1867978 NA 0.51 8.4 0.46 2.68e-15 Cardiovascular disease risk factors; CESC cis rs9910055 0.530 rs2269907 chr17:42294215 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.34 5.03 0.3 8.93e-7 Total body bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11080062 chr12:53615449 RARG -0.42 -6.01 -0.35 5.99e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg15369054 chr17:80825471 TBCD -0.44 -6.06 -0.35 4.76e-9 Breast cancer; CESC cis rs9486719 0.857 rs4265039 chr6:96878929 T/C cg06623918 chr6:96969491 KIAA0776 0.88 10.92 0.56 3.63e-23 Migraine;Coronary artery disease; CESC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.52 0.37 3.63e-10 Prudent dietary pattern; CESC cis rs6598955 0.724 rs12068388 chr1:26621596 G/A cg04990556 chr1:26633338 UBXN11 -0.74 -10.36 -0.54 2.51e-21 Obesity-related traits; CESC cis rs7301826 0.651 rs12820597 chr12:131280185 T/C cg11011512 chr12:131303247 STX2 -0.44 -5.3 -0.31 2.48e-7 Plasma plasminogen activator levels; CESC cis rs2072510 0.593 rs2540499 chr12:96399869 A/C cg09636302 chr12:96389483 HAL 0.42 5.1 0.3 6.34e-7 Metabolite levels (small molecules and protein measures); CESC cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg26597838 chr10:835615 NA 0.79 9.43 0.5 2.18e-18 Eosinophil percentage of granulocytes; CESC cis rs11098499 0.863 rs1480939 chr4:120456927 T/C cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.24e-28 Corneal astigmatism; CESC cis rs1048238 0.506 rs1262788 chr1:16215608 G/C cg22431228 chr1:16359049 CLCNKA 0.37 6.56 0.37 2.75e-10 Systolic blood pressure; CESC cis rs9911578 1.000 rs2531732 chr17:56548420 T/A cg10487724 chr17:56770010 TEX14;RAD51C -0.41 -5.41 -0.32 1.38e-7 Intelligence (multi-trait analysis); CESC cis rs7219451 0.655 rs11869809 chr17:38961122 G/A cg17985300 chr17:38952333 KRT28 -0.32 -5.38 -0.31 1.67e-7 Glucose homeostasis traits; CESC trans rs17685 0.632 rs1859793 chr7:75821283 G/A cg19862616 chr7:65841803 NCRNA00174 0.73 10.11 0.53 1.55e-20 Coffee consumption;Coffee consumption (cups per day); CESC cis rs6901004 0.803 rs405948 chr6:111540372 C/T cg15721981 chr6:111408429 SLC16A10 -0.36 -5.29 -0.31 2.6e-7 Blood metabolite levels; CESC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg11941060 chr3:133502564 NA 0.52 7.22 0.41 5.44e-12 Iron status biomarkers; CESC cis rs4604732 0.536 rs4433437 chr1:247636580 A/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.62 8.19 0.45 1.11e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7633857 0.532 rs9839984 chr3:160768912 C/T cg03342759 chr3:160939853 NMD3 -0.44 -5.85 -0.34 1.45e-8 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13694824 chr11:111957265 TIMM8B;SDHD 0.54 6.02 0.35 5.91e-9 Gut microbiome composition (summer); CESC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg17178900 chr1:205818956 PM20D1 0.42 5.57 0.32 6.18e-8 Parkinson's disease; CESC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg09177884 chr7:1199841 ZFAND2A -0.45 -5.74 -0.33 2.62e-8 Longevity;Endometriosis; CESC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.65 -0.33 4.21e-8 Aortic root size; CESC cis rs7249142 0.549 rs12609573 chr19:19297567 C/T cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B -0.29 -5.37 -0.31 1.74e-7 IgG glycosylation; CESC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg17376030 chr22:41985996 PMM1 0.68 7.52 0.42 8.57e-13 Vitiligo; CESC cis rs1023500 0.552 rs5758566 chr22:42454354 G/A cg15557168 chr22:42548783 NA -0.45 -6.45 -0.37 5.4e-10 Schizophrenia; CESC cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg03467027 chr4:99064603 C4orf37 -0.42 -5.4 -0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9443645 0.509 rs9352668 chr6:79572678 A/G cg05283184 chr6:79620031 NA -0.41 -6.16 -0.35 2.74e-9 Intelligence (multi-trait analysis); CESC cis rs4919687 0.550 rs4264100 chr10:104454113 C/G cg04362960 chr10:104952993 NT5C2 0.44 5.18 0.3 4.47e-7 Colorectal cancer; CESC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg17724175 chr1:150552817 MCL1 0.33 5.08 0.3 7.16e-7 Melanoma; CESC cis rs7914558 0.966 rs1591915 chr10:104646849 C/T cg04362960 chr10:104952993 NT5C2 0.46 6.01 0.35 6.14e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2290405 0.527 rs7663192 chr4:923947 T/C cg04824913 chr4:887549 GAK 0.68 9.18 0.49 1.28e-17 Systemic sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11869233 chr2:48009809 MSH6 -0.55 -6.35 -0.36 9.48e-10 Gut microbiome composition (summer); CESC cis rs10751667 0.666 rs7395402 chr11:950293 A/G cg06064525 chr11:970664 AP2A2 0.48 9.49 0.5 1.46e-18 Alzheimer's disease (late onset); CESC trans rs11039798 0.588 rs12284168 chr11:48555627 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.67 0.38 1.46e-10 Axial length; CESC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg00310523 chr12:86230176 RASSF9 0.37 5.58 0.32 5.98e-8 Major depressive disorder; CESC cis rs6963495 0.818 rs55740553 chr7:105159551 A/G cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs12142240 0.698 rs12385696 chr1:46818836 A/G cg00530320 chr1:46809349 NSUN4 0.57 7.8 0.43 1.39e-13 Menopause (age at onset); CESC cis rs1707322 0.686 rs3014251 chr1:46077428 G/C cg06784218 chr1:46089804 CCDC17 -0.43 -7.41 -0.41 1.7e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg20862496 chr8:143823734 SLURP1 -0.34 -5.28 -0.31 2.65e-7 Urinary tract infection frequency; CESC cis rs898097 0.625 rs2125479 chr17:80890262 A/G cg19046167 chr17:80928561 B3GNTL1 -0.44 -5.57 -0.32 6.22e-8 Breast cancer; CESC cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg02734326 chr4:10020555 SLC2A9 -0.39 -5.38 -0.31 1.62e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs881375 0.631 rs2416808 chr9:123706283 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.54 0.42 7.34e-13 Rheumatoid arthritis; CESC cis rs9611565 0.921 rs8137373 chr22:41729216 A/G cg06634786 chr22:41940651 POLR3H 0.61 6.59 0.38 2.32e-10 Vitiligo; CESC cis rs10870270 1.000 rs10870232 chr10:133738537 T/G cg17892150 chr10:133769511 PPP2R2D -0.85 -12.62 -0.61 6.83e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20382057 chr2:69969052 ANXA4 -0.47 -5.99 -0.35 6.66e-9 Ulcerative colitis; CESC cis rs2486288 0.656 rs11632778 chr15:45551056 C/T cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs6674176 0.542 rs803675 chr1:44353237 G/A cg13606994 chr1:44402422 ARTN -0.37 -5.18 -0.3 4.38e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7089973 0.872 rs7909566 chr10:116629136 A/G cg23260525 chr10:116636907 FAM160B1 0.38 6.42 0.37 6.35e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs74225573 1 rs74225573 chr1:11280994 T/C cg18435880 chr1:11160013 EXOSC10 0.97 6.61 0.38 2.08e-10 Corneal curvature; CESC cis rs477895 1.000 rs2286614 chr11:64068310 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.76 6.61 0.38 2.05e-10 Mean platelet volume; CESC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg24531977 chr5:56204891 C5orf35 0.69 9.31 0.5 5.13e-18 Initial pursuit acceleration; CESC cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg24829409 chr8:58192753 C8orf71 -0.78 -10.18 -0.53 9.38e-21 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 20.43 0.78 2.3e-56 Prudent dietary pattern; CESC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg25985355 chr7:65971099 NA 0.31 5.06 0.3 7.77e-7 Aortic root size; CESC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg09658497 chr7:2847517 GNA12 0.4 5.65 0.33 4.06e-8 Height; CESC cis rs9487051 0.676 rs2222392 chr6:109602303 T/C cg01475377 chr6:109611718 NA -0.45 -7.08 -0.4 1.3e-11 Reticulocyte fraction of red cells; CESC cis rs1348850 0.526 rs2141157 chr2:178374112 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.68 6.17 0.35 2.52e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8017423 0.935 rs11624890 chr14:90738165 T/A cg14092571 chr14:90743983 NA 0.56 8.62 0.47 6.32e-16 Mortality in heart failure; CESC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg09365446 chr1:150670422 GOLPH3L 0.41 5.82 0.34 1.7e-8 Tonsillectomy; CESC cis rs9291683 0.530 rs6449196 chr4:9973660 C/T cg00071950 chr4:10020882 SLC2A9 -0.78 -14.51 -0.67 1.64e-35 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27555392 chr1:16679092 FBXO42 0.59 6.72 0.38 1.1e-10 Gut microbiome composition (summer); CESC cis rs798766 1.000 rs2236786 chr4:1719294 T/C cg10756475 chr4:1757242 NA -0.51 -6.03 -0.35 5.53e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs116095464 0.558 rs28636067 chr5:199415 G/A cg16372103 chr5:203701 NA 0.49 5.3 0.31 2.43e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25954914 chr2:54785183 SPTBN1 0.61 6.95 0.39 2.9e-11 Gut microbiome composition (summer); CESC cis rs10256972 0.528 rs7784607 chr7:1178694 A/G cg04025307 chr7:1156635 C7orf50 0.59 10.22 0.53 7.13e-21 Longevity;Endometriosis; CESC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg19622623 chr12:86230825 RASSF9 0.46 5.93 0.34 9.2e-9 Major depressive disorder; CESC cis rs11601602 0.576 rs4075635 chr11:28511643 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 8.21 0.45 9.97e-15 Obesity-related traits; CESC cis rs1355223 0.525 rs7129517 chr11:34872236 A/C cg11058730 chr11:34937778 PDHX;APIP -0.54 -6.57 -0.37 2.66e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs10754283 0.967 rs6428562 chr1:90102665 G/A cg21401794 chr1:90099060 LRRC8C 0.7 9.42 0.5 2.35e-18 Amyotrophic lateral sclerosis (sporadic); CESC trans rs7395662 0.591 rs4882233 chr11:48739653 A/G cg00717180 chr2:96193071 NA -0.45 -6.11 -0.35 3.51e-9 HDL cholesterol; CESC cis rs7772486 0.790 rs2814879 chr6:146201743 T/C cg05347473 chr6:146136440 FBXO30 0.55 7.26 0.41 4.4e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1729951 0.575 rs361245 chr3:136695706 A/G cg15507776 chr3:136538369 TMEM22 0.41 5.19 0.3 4.2e-7 Neuroticism; CESC cis rs16854884 0.580 rs34924831 chr3:143863020 A/G cg06585982 chr3:143692056 C3orf58 0.43 5.5 0.32 8.85e-8 Economic and political preferences (feminism/equality); CESC cis rs1707322 1.000 rs4074225 chr1:46392364 G/C cg03146154 chr1:46216737 IPP 0.78 10.77 0.55 1.17e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs17685 0.712 rs60232511 chr7:75800082 A/G cg19862616 chr7:65841803 NCRNA00174 0.86 12.2 0.6 1.87e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs10504229 0.871 rs10504226 chr8:58159283 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.03 -0.3 8.84e-7 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg05340658 chr4:99064831 C4orf37 0.81 12.5 0.61 1.75e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6964587 0.626 rs10234074 chr7:91520119 C/T cg17063962 chr7:91808500 NA -0.46 -6.48 -0.37 4.53e-10 Breast cancer; CESC cis rs7605378 0.688 rs769961 chr2:200712141 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.47 5.34 0.31 2.04e-7 Osteoporosis; CESC cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg26769984 chr7:1090371 C7orf50 0.6 6.83 0.39 5.8e-11 Bronchopulmonary dysplasia; CESC cis rs34779708 0.966 rs4934735 chr10:35496730 C/T cg03585969 chr10:35415529 CREM -0.75 -9.78 -0.51 1.8e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg10523679 chr1:76189770 ACADM -0.65 -6.63 -0.38 1.85e-10 Blood metabolite levels;Acylcarnitine levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07940793 chr17:79603854 NPLOC4 -0.45 -6.57 -0.37 2.67e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg17971929 chr21:40555470 PSMG1 1.03 15.1 0.68 1.31e-37 Cognitive function; CESC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg25072359 chr17:41440525 NA 0.47 6.36 0.36 8.86e-10 Menopause (age at onset); CESC cis rs7208859 0.524 rs57670615 chr17:29069498 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg03709012 chr19:19516395 GATAD2A 0.95 13.82 0.65 4.52e-33 Tonsillectomy; CESC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.6 0.33 5.42e-8 Bipolar disorder; CESC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.96 0.39 2.64e-11 Bipolar disorder; CESC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11098499 0.954 rs6848389 chr4:120402622 A/G cg24375607 chr4:120327624 NA 0.46 5.69 0.33 3.36e-8 Corneal astigmatism; CESC cis rs12983728 0.831 rs35081008 chr19:58662235 C/T cg24884572 chr19:58661833 ZNF329 0.58 5.19 0.3 4.16e-7 Cholesterol, total; CESC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.21 -0.41 5.76e-12 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg07507251 chr3:52567010 NT5DC2 0.33 5.67 0.33 3.64e-8 Bipolar disorder; CESC cis rs11098499 0.644 rs10012252 chr4:120559139 T/C cg09307838 chr4:120376055 NA 0.75 9.97 0.52 4.4e-20 Corneal astigmatism; CESC cis rs9300255 0.602 rs4372492 chr12:123697357 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.83 0.48 1.41e-16 Neutrophil percentage of white cells; CESC cis rs7116495 0.609 rs12275171 chr11:71835373 C/T cg07596299 chr11:71824057 C11orf51 0.79 5.03 0.3 9.07e-7 Severe influenza A (H1N1) infection; CESC cis rs2073300 0.609 rs6137937 chr20:23385419 G/A cg12062639 chr20:23401060 NAPB 1.07 8.85 0.48 1.29e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1707322 0.721 rs10789471 chr1:46215619 G/A cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs734999 0.549 rs2764845 chr1:2528999 G/T cg18854424 chr1:2615690 NA -0.27 -5.46 -0.32 1.12e-7 Ulcerative colitis; CESC trans rs6138458 0.828 rs6132785 chr20:24993414 T/C cg13316061 chr18:47798969 MBD1 0.44 6.04 0.35 5.07e-9 Blood protein levels; CESC trans rs11098499 0.774 rs11098505 chr4:120284627 C/T cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs11608355 0.618 rs11066368 chr12:109790342 C/T cg19025524 chr12:109796872 NA -0.51 -7.44 -0.42 1.38e-12 Neuroticism; CESC cis rs9341808 0.600 rs2505930 chr6:80837058 A/G cg08355045 chr6:80787529 NA 0.34 5.04 0.3 8.52e-7 Sitting height ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05062679 chr10:94000186 CPEB3 -0.53 -6.0 -0.35 6.57e-9 Gut microbiome composition (summer); CESC cis rs7927771 0.839 rs3817334 chr11:47650993 C/T cg18512352 chr11:47633146 NA -0.43 -6.56 -0.37 2.82e-10 Subjective well-being; CESC cis rs6088580 0.602 rs6059840 chr20:33030405 G/A cg24642439 chr20:33292090 TP53INP2 0.52 6.8 0.39 7.08e-11 Glomerular filtration rate (creatinine); CESC cis rs4727027 0.933 rs1058059 chr7:148879134 A/T cg23583168 chr7:148888333 NA -0.82 -12.55 -0.61 1.15e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6088580 0.634 rs2378134 chr20:32938085 C/T cg08999081 chr20:33150536 PIGU -0.64 -11.0 -0.56 2.0500000000000001e-23 Glomerular filtration rate (creatinine); CESC cis rs9911578 0.967 rs4076229 chr17:56937256 C/T cg12560992 chr17:57184187 TRIM37 0.94 15.75 0.7 6.57e-40 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg17372223 chr3:52568218 NT5DC2 0.4 5.58 0.32 5.95e-8 Bipolar disorder; CESC trans rs62103177 0.673 rs7242867 chr18:77603270 A/T cg05926928 chr17:57297772 GDPD1 0.75 7.99 0.44 4.26e-14 Opioid sensitivity; CESC cis rs67311347 0.955 rs4974067 chr3:40374551 C/T cg09455208 chr3:40491958 NA 0.49 8.73 0.47 2.86e-16 Renal cell carcinoma; CESC cis rs77106637 0.932 rs7109082 chr11:72707441 A/C cg04827223 chr11:72435913 ARAP1 -0.5 -5.37 -0.31 1.69e-7 Type 2 diabetes; CESC cis rs546131 0.928 rs547504 chr11:34847225 G/T cg06937548 chr11:34938143 PDHX;APIP 0.48 5.85 0.34 1.46e-8 Lung disease severity in cystic fibrosis; CESC cis rs8133932 0.690 rs432338 chr21:47347757 C/T cg14185626 chr21:47401492 COL6A1 -0.48 -5.33 -0.31 2.07e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.7.2254086F chr7:105135578 PUS7 -0.57 -6.63 -0.38 1.87e-10 Gut microbiome composition (summer); CESC cis rs11792861 0.591 rs4978763 chr9:111728067 C/T cg13535736 chr9:111863775 C9orf5 -0.39 -5.64 -0.33 4.25e-8 Menarche (age at onset); CESC cis rs7412746 0.611 rs11204747 chr1:150927152 A/G cg22823121 chr1:150693482 HORMAD1 -0.38 -5.48 -0.32 9.81e-8 Melanoma; CESC cis rs3931020 0.508 rs4145871 chr1:75218704 C/T cg26855724 chr1:75198818 TYW3;CRYZ 0.44 5.17 0.3 4.69e-7 Resistin levels; CESC cis rs5769765 0.955 rs7511159 chr22:50307896 A/G cg02269571 chr22:50332266 NA -0.5 -6.51 -0.37 3.79e-10 Schizophrenia; CESC cis rs3008870 1.000 rs3008859 chr1:67390999 G/C cg02640540 chr1:67518911 SLC35D1 0.49 5.29 0.31 2.6e-7 Lymphocyte percentage of white cells; CESC cis rs832540 0.931 rs1466008 chr5:56213406 G/C cg24531977 chr5:56204891 C5orf35 -0.44 -5.56 -0.32 6.56e-8 Coronary artery disease; CESC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg21951975 chr1:209979733 IRF6 0.6 9.51 0.5 1.18e-18 Cleft lip with or without cleft palate; CESC trans rs853679 0.882 rs9380064 chr6:28143118 A/G cg06606381 chr12:133084897 FBRSL1 -0.66 -6.19 -0.36 2.24e-9 Depression; CESC cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg17366294 chr4:99064904 C4orf37 0.61 8.68 0.47 4.24e-16 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs13356367 chr5:242395 C/T cg20965017 chr5:231967 SDHA -0.47 -5.38 -0.31 1.65e-7 Breast cancer; CESC cis rs2933343 0.729 rs1680781 chr3:128612830 C/A cg24203234 chr3:128598194 ACAD9 0.4 5.21 0.3 3.78e-7 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25416230 chr7:148921410 ZNF282 -0.53 -6.14 -0.35 2.98e-9 Gut microbiome composition (summer); CESC cis rs7520050 0.933 rs12565042 chr1:46299110 C/A cg24296786 chr1:45957014 TESK2 0.42 5.42 0.32 1.33e-7 Red blood cell count;Reticulocyte count; CESC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg17949981 chr6:28129498 ZNF389 -0.47 -5.79 -0.33 2.03e-8 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05725452 chr22:21996709 SDF2L1 -0.56 -6.63 -0.38 1.92e-10 Gut microbiome composition (summer); CESC cis rs2637266 0.678 rs1074181 chr10:78463486 C/T cg18941641 chr10:78392320 NA 0.38 6.85 0.39 5.13e-11 Pulmonary function; CESC cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg21138405 chr5:131827807 IRF1 0.54 9.32 0.5 4.74e-18 Asthma (sex interaction); CESC cis rs75920871 0.589 rs73008568 chr11:117065007 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.76 -5.59 -0.32 5.54e-8 Subjective well-being; CESC cis rs9611565 0.694 rs202637 chr22:41853928 A/G cg06634786 chr22:41940651 POLR3H 0.69 6.82 0.39 6.19e-11 Vitiligo; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg13108601 chr6:41748242 FRS3;PRICKLE4 0.48 6.15 0.35 2.85e-9 Obesity-related traits; CESC cis rs9911578 1.000 rs1494977 chr17:56863064 C/T cg05425664 chr17:57184151 TRIM37 -0.48 -6.55 -0.37 3.03e-10 Intelligence (multi-trait analysis); CESC cis rs7662987 1.000 rs13146416 chr4:99999160 T/C cg13256891 chr4:100009986 ADH5 -0.83 -6.06 -0.35 4.63e-9 Smoking initiation; CESC cis rs1472360 0.505 rs1496526 chr8:86273899 G/A cg21346043 chr8:86351067 CA3 -0.4 -5.61 -0.33 5.15e-8 Mean corpuscular hemoglobin concentration; CESC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg18876405 chr7:65276391 NA 0.47 6.34 0.36 9.84e-10 Aortic root size; CESC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg08888203 chr3:10149979 C3orf24 0.5 6.33 0.36 1.05e-9 Alzheimer's disease; CESC cis rs4803468 0.967 rs1077856 chr19:41885221 T/C cg09537434 chr19:41945824 ATP5SL -1.02 -18.01 -0.74 6.8e-48 Height; CESC cis rs3796619 0.961 rs62294748 chr4:1082999 G/A cg27284194 chr4:1044797 NA 0.37 5.57 0.32 6.24e-8 Recombination rate (males); CESC cis rs9875589 0.509 rs1873005 chr3:14060223 G/A cg19554555 chr3:13937349 NA -0.44 -5.6 -0.33 5.43e-8 Ovarian reserve; CESC cis rs8060686 0.546 rs8047343 chr16:68143745 G/A cg26727032 chr16:67993705 SLC12A4 -0.6 -8.89 -0.48 9.96e-17 HDL cholesterol;Metabolic syndrome; CESC cis rs1707322 0.686 rs2991977 chr1:46053683 G/A cg06784218 chr1:46089804 CCDC17 -0.43 -7.47 -0.42 1.19e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1775715 0.737 rs2799017 chr10:32203460 A/G cg18675610 chr10:32216311 ARHGAP12 0.35 5.34 0.31 1.99e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9549367 0.577 rs513479 chr13:113815200 C/T cg00898013 chr13:113819073 PROZ -0.53 -6.45 -0.37 5.37e-10 Platelet distribution width; CESC trans rs116095464 0.558 rs62346508 chr5:203668 T/C cg00938859 chr5:1591904 SDHAP3 0.66 6.25 0.36 1.66e-9 Breast cancer; CESC cis rs4242434 0.927 rs11136092 chr8:22466488 T/G cg03733263 chr8:22462867 KIAA1967 0.97 14.04 0.65 7.58e-34 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs6665290 0.904 rs10495273 chr1:227183359 T/G cg10327440 chr1:227177885 CDC42BPA -1.22 -34.87 -0.91 5.17e-101 Myeloid white cell count; CESC cis rs11048434 0.666 rs12371786 chr12:9090086 G/A cg23795048 chr12:9217529 LOC144571 0.38 5.89 0.34 1.18e-8 Sjögren's syndrome; CESC cis rs12476592 0.571 rs68183503 chr2:63802888 C/T cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg08888203 chr3:10149979 C3orf24 0.48 5.96 0.34 7.91e-9 Alzheimer's disease; CESC cis rs7726839 0.578 rs10080150 chr5:593160 C/T cg16447950 chr5:562315 NA 0.52 7.52 0.42 8.68e-13 Obesity-related traits; CESC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg09177884 chr7:1199841 ZFAND2A -0.54 -6.08 -0.35 4.25e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25219047 chr19:3500813 DOHH -0.46 -6.63 -0.38 1.87e-10 Gambling; CESC trans rs1814175 0.754 rs28663627 chr11:50048829 C/T cg03929089 chr4:120376271 NA -0.95 -16.28 -0.71 9.18e-42 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09060823 chr12:56862504 SPRYD4 0.56 7.35 0.41 2.44e-12 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22349489 chr6:27114943 HIST1H2BK;HIST1H2AH -0.62 -7.27 -0.41 4.02e-12 Gut microbiome composition (summer); CESC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs7267979 0.966 rs2424715 chr20:25420077 A/G cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.32e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9611565 0.559 rs12483860 chr22:41961916 C/T cg03806693 chr22:41940476 POLR3H -0.97 -12.07 -0.6 4.96e-27 Vitiligo; CESC cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.75 7.65 0.43 3.73e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg19592336 chr6:28129416 ZNF389 0.61 8.24 0.45 8.13e-15 Depression; CESC cis rs7909074 1.000 rs7079573 chr10:45400406 G/A cg05187965 chr10:45406764 TMEM72 -0.33 -5.06 -0.3 7.94e-7 Mean corpuscular volume; CESC cis rs4664308 1.000 rs6719686 chr2:160908292 T/G cg03641300 chr2:160917029 PLA2R1 -0.67 -10.16 -0.53 1.08e-20 Idiopathic membranous nephropathy; CESC cis rs11098499 0.954 rs71629403 chr4:120372567 C/T cg09307838 chr4:120376055 NA 0.92 12.77 0.62 2.08e-29 Corneal astigmatism; CESC cis rs35740288 0.571 rs11631009 chr15:86318653 G/A cg20737812 chr15:86336631 KLHL25 -0.46 -5.41 -0.32 1.38e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs2380220 0.808 rs2716074 chr6:95907662 T/C cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs9329289 0.632 rs2452187 chr10:2551147 C/G cg18171855 chr10:2543474 NA 0.37 5.49 0.32 9.53e-8 Age-related hearing impairment; CESC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg13206674 chr6:150067644 NUP43 0.43 6.27 0.36 1.44e-9 Lung cancer; CESC cis rs7208859 0.573 rs7222803 chr17:29119897 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 11.97 0.59 1.14e-26 Alzheimer's disease; CESC cis rs7927592 0.956 rs11228251 chr11:68244558 G/T cg01657329 chr11:68192670 LRP5 -0.4 -5.18 -0.3 4.46e-7 Total body bone mineral density; CESC cis rs367943 0.712 rs13359330 chr5:112708529 T/C cg12552261 chr5:112820674 MCC 0.4 5.29 0.31 2.55e-7 Type 2 diabetes; CESC cis rs6693567 0.565 rs7544900 chr1:150262333 A/C cg09579323 chr1:150459698 TARS2 -0.46 -5.74 -0.33 2.58e-8 Migraine; CESC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg11764359 chr7:65958608 NA 0.96 15.06 0.68 1.89e-37 Aortic root size; CESC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg03609598 chr5:56110824 MAP3K1 -0.51 -5.54 -0.32 7.13e-8 Initial pursuit acceleration; CESC cis rs4523957 0.890 rs216191 chr17:2188639 C/T cg16513277 chr17:2031491 SMG6 0.6 8.11 0.45 1.95e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs600231 0.706 rs3782091 chr11:65336483 G/T cg17120908 chr11:65337727 SSSCA1 0.53 5.91 0.34 1.07e-8 Bone mineral density; CESC cis rs710216 0.843 rs844501 chr1:43440783 G/A cg03128534 chr1:43423976 SLC2A1 0.49 5.41 0.32 1.38e-7 Red cell distribution width; CESC trans rs11098499 0.863 rs6858777 chr4:120475966 A/G cg25214090 chr10:38739885 LOC399744 0.66 9.03 0.49 3.57e-17 Corneal astigmatism; CESC cis rs644799 1.000 rs505220 chr11:95563228 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.57e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1568889 1.000 rs61889026 chr11:28274803 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.71 8.36 0.46 3.6e-15 Bipolar disorder; CESC cis rs854765 0.583 rs9904163 chr17:17830553 C/T cg16928487 chr17:17741425 SREBF1 -0.57 -9.74 -0.51 2.41e-19 Total body bone mineral density; CESC cis rs2342371 0.527 rs7643192 chr3:196210590 A/G cg15048948 chr3:196158458 UBXN7 -0.4 -5.57 -0.32 6.36e-8 Fat distribution (HIV); CESC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg05776053 chr2:74358815 NA 0.4 5.07 0.3 7.39e-7 Gestational age at birth (maternal effect); CESC cis rs1348850 0.519 rs1544002 chr2:178529534 C/T cg23306229 chr2:178417860 TTC30B 0.46 5.29 0.31 2.6e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10463316 0.894 rs7710277 chr5:150767405 T/C cg03212797 chr5:150827313 SLC36A1 -0.47 -6.2 -0.36 2.17e-9 Metabolite levels (Pyroglutamine); CESC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg04553112 chr3:125709451 NA -0.53 -5.69 -0.33 3.27e-8 Blood pressure (smoking interaction); CESC cis rs7845219 0.544 rs7015841 chr8:95920193 A/C cg23172400 chr8:95962367 TP53INP1 -0.38 -7.08 -0.4 1.3e-11 Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18266620 chr1:110882148 RBM15 -0.48 -6.08 -0.35 4.08e-9 Fibrinogen levels; CESC cis rs9814567 0.806 rs4074522 chr3:134325626 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.4 5.25 0.31 3.19e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs12136530 0.651 rs10753561 chr1:19711939 T/C cg01832549 chr1:19774989 CAPZB -0.36 -5.33 -0.31 2.08e-7 Lead levels in blood; CESC trans rs11115322 1.000 rs11115323 chr12:83019495 C/T cg10309835 chr19:48894715 KDELR1 -0.92 -6.03 -0.35 5.36e-9 Immune response to smallpox vaccine (IL-6); CESC cis rs10751667 0.643 rs10902238 chr11:944810 G/A cg20946044 chr11:1010712 AP2A2 -0.4 -5.54 -0.32 7.24e-8 Alzheimer's disease (late onset); CESC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.39 5.15 0.3 5.1e-7 Bipolar disorder; CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg04025307 chr7:1156635 C7orf50 0.41 5.32 0.31 2.23e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9858542 1.000 rs9836291 chr3:49697459 G/A cg07274523 chr3:49395745 GPX1 0.68 8.72 0.47 3.1e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg27165867 chr14:105738592 BRF1 -0.56 -6.26 -0.36 1.51e-9 Mean platelet volume;Platelet distribution width; CESC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.39 -5.3 -0.31 2.38e-7 Total body bone mineral density; CESC cis rs4555082 1.000 rs7146683 chr14:105759385 A/G cg10792982 chr14:105748885 BRF1 0.37 5.08 0.3 7.25e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg03676636 chr4:99064102 C4orf37 0.35 5.26 0.31 3.02e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg25783544 chr11:47291846 MADD 0.45 5.19 0.3 4.12e-7 Subjective well-being; CESC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg00815214 chr21:47717953 NA 0.43 6.27 0.36 1.49e-9 Testicular germ cell tumor; CESC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg18230493 chr5:56204884 C5orf35 -0.67 -8.26 -0.45 7.07e-15 Initial pursuit acceleration; CESC cis rs12118280 0.512 rs7418288 chr1:108754099 G/A cg11967332 chr1:108735228 SLC25A24 0.65 6.56 0.37 2.76e-10 Myeloid white cell count; CESC cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.91e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8060686 0.545 rs12598630 chr16:68258852 T/G cg26727032 chr16:67993705 SLC12A4 -0.48 -5.18 -0.3 4.5e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg07157834 chr1:205819609 PM20D1 0.76 12.05 0.59 5.9e-27 Menarche (age at onset); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg02004021 chr12:95868393 METAP2 -0.49 -6.42 -0.37 6.12e-10 Height; CESC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.72 6.41 0.37 6.71e-10 Platelet count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07661849 chr4:146686236 ZNF827 0.44 6.13 0.35 3.16e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8072100 0.811 rs9889709 chr17:45445229 C/T cg08085267 chr17:45401833 C17orf57 -0.56 -7.4 -0.41 1.81e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7100689 0.753 rs4934125 chr10:82147466 T/C cg00277334 chr10:82204260 NA -0.6 -7.5 -0.42 9.66e-13 Post bronchodilator FEV1; CESC cis rs13242816 0.892 rs34645128 chr7:116078382 T/A cg04696780 chr7:116139425 CAV2 -0.65 -5.7 -0.33 3.2e-8 P wave duration; CESC cis rs4319547 1.000 rs4319547 chr12:123079035 A/G cg05707623 chr12:122985044 ZCCHC8 -0.59 -6.81 -0.39 6.63e-11 Body mass index; CESC cis rs7216064 0.953 rs12450907 chr17:65870644 T/G cg12091567 chr17:66097778 LOC651250 -0.85 -8.7 -0.47 3.61e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs113835537 0.529 rs3892818 chr11:66240191 C/T cg24851651 chr11:66362959 CCS 0.45 5.9 0.34 1.1e-8 Airway imaging phenotypes; CESC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25195416 chr21:46696626 POFUT2 0.57 7.65 0.43 3.67e-13 Fibrinogen levels; CESC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg05368731 chr17:41323189 NBR1 0.8 10.68 0.55 2.29e-22 Menopause (age at onset); CESC trans rs9858542 1.000 rs34762726 chr3:49689210 G/A cg21659725 chr3:3221576 CRBN -0.53 -6.49 -0.37 4.09e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg22105103 chr4:187893119 NA 0.51 7.33 0.41 2.79e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs4132509 0.779 rs6656918 chr1:243706224 G/A cg21452805 chr1:244014465 NA -0.43 -5.31 -0.31 2.33e-7 RR interval (heart rate); CESC trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -8.4 -0.46 2.72e-15 Intelligence (multi-trait analysis); CESC cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg20476274 chr7:133979776 SLC35B4 0.67 9.82 0.52 1.31e-19 Mean platelet volume; CESC cis rs4970966 1.000 rs4970966 chr1:150584103 A/C cg13175981 chr1:150552382 MCL1 -0.53 -5.89 -0.34 1.15e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs72781680 0.752 rs55801864 chr2:23922325 C/T cg08917208 chr2:24149416 ATAD2B 1.12 10.1 0.53 1.66e-20 Lymphocyte counts; CESC cis rs6032067 0.929 rs2233898 chr20:43850525 A/G cg10761708 chr20:43804764 PI3 0.52 6.22 0.36 1.92e-9 Blood protein levels; CESC cis rs8180040 0.620 rs4683322 chr3:47093189 T/C cg27129171 chr3:47204927 SETD2 0.67 9.83 0.52 1.18e-19 Colorectal cancer; CESC cis rs6121246 0.567 rs6060295 chr20:30198473 C/T cg13852791 chr20:30311386 BCL2L1 0.58 5.47 0.32 1.03e-7 Mean corpuscular hemoglobin; CESC cis rs6964587 0.626 rs7807765 chr7:91531974 C/A cg17063962 chr7:91808500 NA -0.45 -6.39 -0.37 7.49e-10 Breast cancer; CESC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg05255149 chr17:80675120 FN3KRP -0.5 -5.65 -0.33 4.13e-8 Breast cancer; CESC cis rs9308731 1.000 rs6746608 chr2:111892984 C/T cg04202892 chr2:111875749 ACOXL -0.38 -5.45 -0.32 1.17e-7 Chronic lymphocytic leukemia; CESC cis rs6032067 1.000 rs6017509 chr20:43830362 A/G cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.56e-7 Blood protein levels; CESC cis rs7267979 0.739 rs6138555 chr20:25242910 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.73 11.8 0.59 4.01e-26 Liver enzyme levels (alkaline phosphatase); CESC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs367943 0.666 rs7717422 chr5:112704089 A/G cg12552261 chr5:112820674 MCC 0.42 5.53 0.32 7.73e-8 Type 2 diabetes; CESC cis rs16966142 1.000 rs3890534 chr16:89835289 A/G cg04287289 chr16:89883240 FANCA -0.67 -6.02 -0.35 5.79e-9 Caffeine consumption; CESC cis rs11112613 1.000 rs11112613 chr12:106003786 A/G cg03607813 chr12:105948248 NA 0.53 5.48 0.32 9.79e-8 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs10733682 0.524 rs10987419 chr9:129462594 T/C cg00232160 chr9:129468157 NA 0.42 6.63 0.38 1.9e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06419771 chr15:42264912 EHD4 0.46 6.06 0.35 4.63e-9 Systemic lupus erythematosus; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22465281 chr5:65017296 NLN;SGTB -0.44 -6.24 -0.36 1.69e-9 Gut microbiota (bacterial taxa); CESC cis rs2836633 0.929 rs62217519 chr21:40034390 G/A cg12884169 chr21:40033163 ERG 0.37 5.77 0.33 2.19e-8 Coronary artery disease; CESC cis rs2573652 1.000 rs1469829 chr15:100517332 A/G cg09918751 chr15:100517450 ADAMTS17 -0.44 -8.45 -0.46 1.95e-15 Height; CESC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg09913183 chr17:42254507 C17orf65;ASB16 0.65 8.44 0.46 2.12e-15 Total body bone mineral density; CESC cis rs2486288 0.656 rs12910009 chr15:45572408 A/G cg21132104 chr15:45694354 SPATA5L1 -0.56 -6.7 -0.38 1.22e-10 Glomerular filtration rate; CESC cis rs3733585 0.699 rs6449177 chr4:9968050 T/C cg00071950 chr4:10020882 SLC2A9 -0.68 -10.88 -0.56 5.05e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8072100 0.676 rs9908049 chr17:45502096 G/C cg25173405 chr17:45401733 C17orf57 -0.43 -5.43 -0.32 1.26e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg11764359 chr7:65958608 NA 0.79 11.38 0.57 1.11e-24 Aortic root size; CESC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg27266027 chr21:40555129 PSMG1 0.49 6.01 0.35 6.02e-9 Cognitive function; CESC cis rs2952156 0.684 rs1877031 chr17:37814080 G/A cg00129232 chr17:37814104 STARD3 -0.82 -12.26 -0.6 1.11e-27 Asthma; CESC cis rs864537 0.676 rs1773560 chr1:167421763 A/G cg09179987 chr1:167433047 CD247 0.5 7.43 0.42 1.54e-12 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs12079745 0.793 rs11802239 chr1:169128802 C/T cg09363564 chr1:169337483 NME7;BLZF1 -1.13 -6.54 -0.37 3.19e-10 QT interval; CESC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg26554054 chr8:600488 NA -0.7 -5.39 -0.31 1.57e-7 IgG glycosylation; CESC trans rs7980799 0.935 rs9888363 chr12:33529288 A/G cg26384229 chr12:38710491 ALG10B -0.48 -6.67 -0.38 1.53e-10 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs11098499 0.954 rs10005644 chr4:120298477 T/C cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.05e-12 Total body bone mineral density; CESC cis rs3845702 0.736 rs6433818 chr2:180810264 A/T cg01881094 chr2:180872142 CWC22 -1.05 -8.97 -0.48 5.56e-17 Schizophrenia; CESC cis rs7590368 0.600 rs3856466 chr2:10916770 C/T cg15705551 chr2:10952987 PDIA6 0.58 5.24 0.31 3.2e-7 Educational attainment (years of education); CESC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg18402987 chr7:1209562 NA 0.77 7.88 0.44 8.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3820068 0.581 rs72645871 chr1:15926142 G/A cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs12477438 0.520 rs34766932 chr2:99737273 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 15.55 0.69 3.41e-39 Chronic sinus infection; CESC cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg06453172 chr10:134556979 INPP5A -0.42 -5.47 -0.32 1.04e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4664308 0.967 rs62175559 chr2:160955833 G/A cg03641300 chr2:160917029 PLA2R1 -0.66 -9.7 -0.51 3.12e-19 Idiopathic membranous nephropathy; CESC cis rs9399137 0.507 rs13197750 chr6:135312380 G/A cg24558204 chr6:135376177 HBS1L 0.72 10.08 0.53 1.92e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs4588572 0.686 rs67689570 chr5:77676843 T/C cg11547950 chr5:77652471 NA 0.46 5.91 0.34 1.06e-8 Triglycerides; CESC cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4803468 0.967 rs4802116 chr19:41905540 C/T cg14132834 chr19:41945861 ATP5SL -0.61 -7.74 -0.43 2.09e-13 Height; CESC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg25767906 chr1:53392781 SCP2 -0.46 -5.98 -0.34 7.09e-9 Monocyte count; CESC cis rs9486719 0.857 rs2971609 chr6:97039665 A/G cg06623918 chr6:96969491 KIAA0776 -0.86 -10.51 -0.54 8.28e-22 Migraine;Coronary artery disease; CESC cis rs9948 0.786 rs62156227 chr2:97417942 C/A cg01990225 chr2:97406019 LMAN2L -0.94 -7.51 -0.42 9.27e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs4218 0.636 rs4775116 chr15:59427807 A/G cg10589330 chr15:60383523 NA -0.24 -5.03 -0.3 8.93e-7 Social communication problems; CESC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC trans rs9329221 0.619 rs591346 chr8:9818065 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -6.6 -0.38 2.2e-10 Neuroticism; CESC cis rs7408868 0.831 rs7245850 chr19:15274585 A/C cg14696996 chr19:15285081 NOTCH3 1.12 11.42 0.57 8.06e-25 Pulse pressure; CESC cis rs7123876 0.504 rs1157343 chr11:72429141 A/G cg04827223 chr11:72435913 ARAP1 0.57 9.61 0.51 5.75e-19 Body mass index; CESC cis rs12545109 0.765 rs2610047 chr8:57412106 T/C cg09654669 chr8:57350985 NA -0.46 -6.28 -0.36 1.4e-9 Obesity-related traits; CESC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg12756686 chr19:29218302 NA 0.59 7.62 0.42 4.52e-13 Methadone dose in opioid dependence; CESC cis rs2070488 0.804 rs6764551 chr3:38460305 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 12.28 0.6 9.75e-28 Electrocardiographic conduction measures; CESC cis rs644799 1.000 rs3177463 chr11:95502128 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.87 0.39 4.5e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs68170813 0.559 rs2249043 chr7:106960515 C/T cg02696742 chr7:106810147 HBP1 -0.55 -5.2 -0.3 3.95e-7 Coronary artery disease; CESC cis rs4268898 0.662 rs72793213 chr2:24524725 A/G cg06627628 chr2:24431161 ITSN2 -0.99 -11.33 -0.57 1.59e-24 Asthma; CESC cis rs854765 0.505 rs4506969 chr17:17899839 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.76 0.47 2.4e-16 Total body bone mineral density; CESC cis rs17023223 0.537 rs12065809 chr1:119724535 A/T cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs748404 0.631 rs3809482 chr15:43661802 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.61 8.0 0.44 3.8e-14 Lung cancer; CESC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg04248312 chr19:17393744 ANKLE1 -0.93 -15.31 -0.69 2.39e-38 Systemic lupus erythematosus; CESC trans rs877282 0.898 rs11253343 chr10:765117 C/T cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs9303542 0.559 rs2229302 chr17:46620402 G/A cg04904318 chr17:46607828 HOXB1 -0.57 -5.51 -0.32 8.4e-8 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs9911578 0.935 rs117819974 chr17:57002324 C/T cg12560992 chr17:57184187 TRIM37 0.94 15.56 0.69 3.21e-39 Intelligence (multi-trait analysis); CESC cis rs826838 1.000 rs11610522 chr12:38687575 C/T cg26384229 chr12:38710491 ALG10B 0.84 14.86 0.67 9.58e-37 Heart rate; CESC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg04414720 chr1:150670196 GOLPH3L 0.47 6.42 0.37 6.09e-10 Tonsillectomy; CESC trans rs2727020 0.521 rs7107178 chr11:49526668 G/A cg03929089 chr4:120376271 NA 0.69 7.8 0.43 1.43e-13 Coronary artery disease; CESC cis rs12200560 0.505 rs59296768 chr6:97075535 C/T cg06623918 chr6:96969491 KIAA0776 0.5 6.49 0.37 4.13e-10 Coronary heart disease; CESC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg04414720 chr1:150670196 GOLPH3L 0.56 7.41 0.41 1.7e-12 Melanoma; CESC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg02725872 chr8:58115012 NA -0.48 -7.55 -0.42 7.13e-13 Developmental language disorder (linguistic errors); CESC cis rs8060686 0.641 rs7204192 chr16:68039309 A/G cg26727032 chr16:67993705 SLC12A4 -0.55 -7.31 -0.41 3.24e-12 HDL cholesterol;Metabolic syndrome; CESC cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg07636037 chr3:49044803 WDR6 0.61 7.16 0.4 8.07e-12 Menarche (age at onset); CESC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg26441486 chr22:50317300 CRELD2 0.4 5.16 0.3 4.95e-7 Schizophrenia; CESC cis rs9467773 0.620 rs9467810 chr6:26608261 A/C cg26531700 chr6:26746687 NA -0.42 -6.43 -0.37 6.02e-10 Intelligence (multi-trait analysis); CESC cis rs854765 0.583 rs4925125 chr17:17794444 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.64 -9.44 -0.5 2e-18 Total body bone mineral density; CESC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.904 rs2338798 chr17:37547269 T/C cg15445000 chr17:37608096 MED1 -0.39 -6.43 -0.37 5.89e-10 Glomerular filtration rate (creatinine); CESC cis rs6570726 0.875 rs368744 chr6:145812622 A/G cg05347473 chr6:146136440 FBXO30 0.48 6.46 0.37 4.93e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7254114 0.618 rs7250652 chr19:11302606 A/G cg02815516 chr19:11306319 KANK2 -0.37 -6.21 -0.36 2.05e-9 Immature fraction of reticulocytes; CESC cis rs854765 0.552 rs11078407 chr17:17841083 T/C cg16928487 chr17:17741425 SREBF1 -0.53 -9.09 -0.49 2.48e-17 Total body bone mineral density; CESC cis rs11640734 0.609 rs11647746 chr16:89806343 C/A cg04287289 chr16:89883240 FANCA 0.65 5.67 0.33 3.66e-8 Interleukin-17 levels; CESC cis rs1050631 1.000 rs2236718 chr18:33705135 G/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.4 5.28 0.31 2.69e-7 Esophageal squamous cell cancer (length of survival); CESC cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.26 0.31 2.97e-7 Tonsillectomy; CESC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg04287289 chr16:89883240 FANCA -0.48 -5.94 -0.34 9.05e-9 Vitiligo; CESC cis rs11077998 0.844 rs1109123 chr17:80522391 T/C cg10255544 chr17:80519551 FOXK2 0.55 8.78 0.47 2.02e-16 Reticulocyte fraction of red cells; CESC cis rs56309584 0.715 rs77224069 chr17:8124268 G/C cg06726167 chr17:8076949 TMEM107 -0.5 -5.07 -0.3 7.42e-7 Initial pursuit acceleration; CESC cis rs3008870 0.755 rs2815360 chr1:67494458 C/T cg02640540 chr1:67518911 SLC35D1 0.44 5.36 0.31 1.84e-7 Lymphocyte percentage of white cells; CESC cis rs4629710 0.568 rs9492883 chr6:131573872 A/T cg12606694 chr6:131520996 AKAP7 0.48 5.9 0.34 1.08e-8 Multiple myeloma (IgH translocation); CESC cis rs763121 0.785 rs5757199 chr22:39040617 T/G cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC cis rs6120849 0.851 rs13040631 chr20:33747714 T/C cg24642439 chr20:33292090 TP53INP2 0.6 6.37 0.36 8.21e-10 Protein C levels; CESC cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg06027949 chr8:82754900 SNX16 -0.44 -5.32 -0.31 2.21e-7 Diastolic blood pressure; CESC cis rs6964587 0.967 rs13233496 chr7:91813035 T/C cg17063962 chr7:91808500 NA 0.57 7.79 0.43 1.56e-13 Breast cancer; CESC cis rs2070677 0.935 rs11101880 chr10:135412888 T/C cg20169779 chr10:135381914 SYCE1 -0.76 -10.04 -0.53 2.53e-20 Gout; CESC cis rs8141529 0.719 rs2097461 chr22:29191879 T/C cg15103426 chr22:29168792 CCDC117 0.71 10.08 0.53 1.98e-20 Lymphocyte counts; CESC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg18876405 chr7:65276391 NA 0.68 9.54 0.51 9.97e-19 Calcium levels; CESC cis rs7772486 0.875 rs2748482 chr6:146336532 T/C cg05347473 chr6:146136440 FBXO30 0.52 6.71 0.38 1.17e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs950776 0.531 rs12915652 chr15:78831928 G/A cg06917634 chr15:78832804 PSMA4 0.81 12.07 0.6 5.08e-27 Sudden cardiac arrest; CESC cis rs3109167 0.524 rs2713182 chr7:83097221 T/A cg14519356 chr7:83097669 SEMA3E 0.43 5.84 0.34 1.53e-8 Blood protein levels; CESC cis rs9324022 0.929 rs12888043 chr14:101170436 A/G cg18089426 chr14:101175970 NA -0.59 -6.87 -0.39 4.67e-11 Plateletcrit; CESC trans rs6759922 1.000 rs7599198 chr2:22451138 A/T cg21162304 chr4:80247171 NAA11 0.37 6.13 0.35 3.24e-9 Subjective well-being (multi-trait analysis); CESC cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.06 10.27 0.53 4.91e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs992157 0.798 rs4674284 chr2:219161241 C/T cg00012203 chr2:219082015 ARPC2 -0.74 -9.46 -0.5 1.7e-18 Colorectal cancer; CESC cis rs1878931 0.582 rs27225 chr16:3428060 G/A cg02880119 chr16:3481970 NA 0.41 5.21 0.3 3.81e-7 Body mass index (adult); CESC cis rs6831352 1.000 rs6831352 chr4:100063525 T/C cg13256891 chr4:100009986 ADH5 0.7 8.0 0.44 3.83e-14 Alcohol dependence; CESC cis rs6580649 0.941 rs1793931 chr12:48396505 G/T cg24011408 chr12:48396354 COL2A1 0.41 5.31 0.31 2.28e-7 Lung cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09145139 chr10:95256412 CEP55 -0.46 -6.5 -0.37 3.99e-10 Gambling; CESC cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg22875332 chr1:76189707 ACADM 0.64 7.7 0.43 2.76e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6537837 0.887 rs1889470 chr1:110141421 A/G cg05049280 chr1:110155535 GNAT2 0.31 5.11 0.3 6.32e-7 Major depressive disorder; CESC cis rs727563 0.520 rs132773 chr22:42031768 T/A cg17376030 chr22:41985996 PMM1 -0.8 -9.14 -0.49 1.64e-17 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18105612 chr14:71289522 NA 0.53 6.13 0.35 3.22e-9 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17510320 chr11:66360559 CCS;CCDC87 0.46 6.03 0.35 5.35e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg18252515 chr7:66147081 NA 0.48 6.43 0.37 5.77e-10 Aortic root size; CESC cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg11812906 chr14:75593930 NEK9 -0.85 -14.12 -0.66 4e-34 Height; CESC cis rs11711311 0.911 rs9831422 chr3:113398195 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.67 8.6 0.47 7.08e-16 IgG glycosylation; CESC cis rs75064307 0.834 rs4855560 chr3:108116129 G/C cg03329597 chr3:108125523 MYH15 0.51 5.68 0.33 3.48e-8 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10315922 chr12:66563928 TMBIM4 -0.55 -6.53 -0.37 3.44e-10 Gut microbiome composition (summer); CESC cis rs2637266 0.775 rs2579744 chr10:78311824 A/G cg18941641 chr10:78392320 NA 0.34 6.14 0.35 2.94e-9 Pulmonary function; CESC cis rs12042938 0.935 rs1417585 chr1:231803604 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 6.15 0.35 2.8e-9 Neuranatomic and neurocognitive phenotypes; CESC cis rs919433 0.927 rs3843857 chr2:198195965 T/C cg10820045 chr2:198174542 NA -0.43 -6.11 -0.35 3.54e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg05368731 chr17:41323189 NBR1 0.78 10.59 0.55 4.23e-22 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06742978 chr12:50451907 ACCN2 -0.42 -6.36 -0.36 8.68e-10 Gambling; CESC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg18446336 chr7:2847575 GNA12 -0.34 -5.19 -0.3 4.29e-7 Height; CESC cis rs7605827 0.930 rs2160691 chr2:15598197 G/A cg19274914 chr2:15703543 NA 0.36 6.39 0.37 7.33e-10 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04407233 chr1:10042538 NMNAT1 -0.65 -7.51 -0.42 9.09e-13 Gut microbiome composition (summer); CESC cis rs921968 0.541 rs733925 chr2:219302466 G/A cg02176678 chr2:219576539 TTLL4 -0.45 -7.85 -0.43 1.04e-13 Mean corpuscular hemoglobin concentration; CESC cis rs1670533 1.000 rs10031302 chr4:1059664 G/A cg04106633 chr4:1044584 NA 0.41 5.33 0.31 2.11e-7 Recombination rate (females); CESC cis rs910316 0.967 rs175505 chr14:75529619 C/T cg11812906 chr14:75593930 NEK9 -0.88 -15.0 -0.68 3.01e-37 Height; CESC cis rs9287719 0.934 rs4622695 chr2:10744327 C/T cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg26516362 chr5:178986906 RUFY1 0.44 7.03 0.4 1.7e-11 Lung cancer; CESC cis rs2228479 1.000 rs11642267 chr16:89957635 T/C cg14709524 chr16:89940631 TCF25 0.87 6.44 0.37 5.45e-10 Skin colour saturation; CESC cis rs1707322 1.000 rs1613296 chr1:46546852 A/C cg03146154 chr1:46216737 IPP -0.59 -6.67 -0.38 1.5e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4332037 0.707 rs4721096 chr7:1877311 T/C cg13880726 chr7:1868755 MAD1L1 0.54 5.41 0.32 1.4e-7 Bipolar disorder; CESC cis rs7580658 0.864 rs3088374 chr2:128062048 T/C cg10021288 chr2:128175891 PROC -0.35 -5.7 -0.33 3.21e-8 Protein C levels; CESC cis rs4523957 0.928 rs4790071 chr17:2173184 A/G cg16513277 chr17:2031491 SMG6 -0.6 -8.01 -0.44 3.55e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg22535103 chr8:58192502 C8orf71 -0.93 -12.03 -0.59 6.97e-27 Developmental language disorder (linguistic errors); CESC cis rs6582630 0.502 rs11181214 chr12:38298313 C/A cg13010199 chr12:38710504 ALG10B 0.46 5.88 0.34 1.26e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs2635047 0.530 rs4986228 chr18:44595259 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.48 -5.94 -0.34 8.95e-9 Educational attainment; CESC trans rs9916302 0.752 rs6503513 chr17:37561613 A/G cg04245439 chr3:142607978 PCOLCE2 -0.51 -6.19 -0.36 2.33e-9 Glomerular filtration rate (creatinine); CESC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.15 0.4 8.48e-12 Height; CESC cis rs4072980 0.524 rs28477803 chr1:38398694 C/T cg26528311 chr1:38462546 FHL3 0.33 5.04 0.3 8.66e-7 Coronary artery disease; CESC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg12463550 chr7:65579703 CRCP 0.59 7.42 0.41 1.55e-12 Aortic root size; CESC cis rs992157 0.796 rs55680399 chr2:219160621 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.7 9.53 0.51 1.06e-18 Colorectal cancer; CESC trans rs11098499 0.954 rs11940028 chr4:120411907 T/C cg25214090 chr10:38739885 LOC399744 0.72 10.08 0.53 1.97e-20 Corneal astigmatism; CESC cis rs7474896 0.583 rs34185758 chr10:37990854 T/C cg25427524 chr10:38739819 LOC399744 -0.49 -5.39 -0.31 1.57e-7 Obesity (extreme); CESC cis rs6800768 0.663 rs59911620 chr3:24092004 G/C cg10674438 chr3:24145617 LOC152024 -0.42 -5.77 -0.33 2.26e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs523395 0.630 rs616111 chr1:120269991 C/G cg19096424 chr1:120255104 PHGDH -0.61 -7.64 -0.42 3.93e-13 Red blood cell count; CESC cis rs6964587 0.626 rs4422709 chr7:91510968 A/G cg17063962 chr7:91808500 NA -0.44 -6.25 -0.36 1.65e-9 Breast cancer; CESC cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.76e-28 Colonoscopy-negative controls vs population controls; CESC cis rs11945232 1.000 rs28609242 chr4:88342497 T/C cg23841344 chr4:88312519 HSD17B11 -0.63 -7.81 -0.43 1.32e-13 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02471319 chr12:4647845 RAD51AP1;C12orf4 0.38 6.04 0.35 5.16e-9 Gambling; CESC cis rs3806843 0.771 rs801174 chr5:140112712 C/T cg16179182 chr5:140090404 VTRNA1-1 0.44 5.77 0.33 2.25e-8 Depressive symptoms (multi-trait analysis); CESC cis rs757081 0.738 rs1073443 chr11:17350394 C/T cg15432903 chr11:17409602 KCNJ11 -0.5 -6.24 -0.36 1.72e-9 Systolic blood pressure; CESC cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs57506017 0.585 rs3815535 chr7:12270519 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.17 0.3 4.56e-7 Neuroticism; CESC cis rs11122272 0.637 rs2808593 chr1:231524228 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs858239 0.508 rs10242104 chr7:23220450 C/T cg23682824 chr7:23144976 KLHL7 0.45 5.81 0.34 1.8e-8 Cerebrospinal fluid biomarker levels; CESC cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg18876405 chr7:65276391 NA 0.49 5.38 0.31 1.63e-7 Aortic root size; CESC cis rs870825 0.860 rs72703518 chr4:185602109 T/C cg04058563 chr4:185651563 MLF1IP 0.6 5.43 0.32 1.28e-7 Blood protein levels; CESC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg11890956 chr21:40555474 PSMG1 -0.67 -9.52 -0.5 1.14e-18 Menarche (age at onset); CESC cis rs7666738 0.830 rs13122456 chr4:98936011 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 1.000 rs34637256 chr7:65360131 G/A cg12463550 chr7:65579703 CRCP 0.68 5.51 0.32 8.7e-8 Diabetic kidney disease; CESC cis rs2406342 0.528 rs75536638 chr18:74499060 G/T cg24983120 chr18:74499380 NA 0.45 6.04 0.35 5.29e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); CESC cis rs7917772 0.582 rs12779854 chr10:104358474 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.4 -5.4 -0.31 1.5e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs8180040 0.620 rs11720139 chr3:47036756 C/G cg27129171 chr3:47204927 SETD2 -0.66 -9.5 -0.5 1.31e-18 Colorectal cancer; CESC cis rs17253792 0.822 rs10483650 chr14:56145312 A/G cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC trans rs2658782 0.789 rs56091149 chr11:93073640 A/C cg03479527 chr8:145637966 SLC39A4 0.42 6.07 0.35 4.39e-9 Pulmonary function decline; CESC cis rs765787 0.530 rs4775831 chr15:45534722 A/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs7264396 0.747 rs2425151 chr20:34394541 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.66 0.43 3.58e-13 Total cholesterol levels; CESC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg12463550 chr7:65579703 CRCP 0.56 7.07 0.4 1.39e-11 Aortic root size; CESC cis rs78366141 0.649 rs78959409 chr4:89659712 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.88 5.86 0.34 1.34e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs780096 0.526 rs11682621 chr2:27749669 G/A cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.34 -0.31 1.97e-7 Total body bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16208271 chr20:25176149 ENTPD6 -0.43 -6.14 -0.35 3.05e-9 Gambling; CESC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg23982607 chr1:1823379 GNB1 0.5 7.17 0.4 7.35e-12 Body mass index; CESC cis rs1707322 0.752 rs7541962 chr1:46235117 G/A cg05343316 chr1:45956843 TESK2 0.52 6.49 0.37 4.25e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4523957 0.583 rs903159 chr17:2055109 C/T cg16513277 chr17:2031491 SMG6 -0.76 -11.02 -0.56 1.68e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs561341 1.000 rs4795668 chr17:30244554 G/A cg20587970 chr11:113659929 NA -1.11 -13.47 -0.64 7.57e-32 Hip circumference adjusted for BMI; CESC cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs35110281 0.714 rs2282526 chr21:45080552 A/T cg04455712 chr21:45112962 RRP1B 0.42 6.04 0.35 5.25e-9 Mean corpuscular volume; CESC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg01341218 chr17:43662625 NA -0.85 -10.53 -0.54 6.95e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7267979 0.932 rs449370 chr20:25451180 A/G cg08601574 chr20:25228251 PYGB -0.38 -5.5 -0.32 9.11e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.37 0.61 4.65e-28 Colonoscopy-negative controls vs population controls; CESC cis rs12079745 0.623 rs2901092 chr1:169456393 A/G cg09363564 chr1:169337483 NME7;BLZF1 -0.91 -6.0 -0.35 6.28e-9 QT interval; CESC cis rs523522 0.962 rs4766968 chr12:120947788 G/C cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs748404 0.697 rs1095389 chr15:43566671 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.82 0.43 1.29e-13 Lung cancer; CESC cis rs2832077 0.506 rs2832093 chr21:30164855 C/T cg24692254 chr21:30365293 RNF160 -0.51 -6.15 -0.35 2.85e-9 Cognitive test performance; CESC cis rs1707322 0.721 rs12049027 chr1:46118184 A/T cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs116095464 0.558 rs7714335 chr5:263513 T/C cg00938859 chr5:1591904 SDHAP3 0.7 7.2 0.4 6.24e-12 Breast cancer; CESC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg20151795 chr6:28129481 ZNF389 0.45 5.92 0.34 9.77e-9 Depression; CESC trans rs11770686 0.967 rs4728289 chr7:75348505 C/T cg00742472 chr14:31889912 NA -0.41 -6.21 -0.36 2.03e-9 Essential tremor; CESC cis rs1506636 0.886 rs6945841 chr7:123266094 G/A cg03229431 chr7:123269106 ASB15 -0.51 -6.83 -0.39 5.89e-11 Plateletcrit;Platelet count; CESC cis rs2742234 0.503 rs1254968 chr10:43691691 C/T cg15436174 chr10:43711423 RASGEF1A 0.5 5.88 0.34 1.21e-8 Hirschsprung disease; CESC cis rs4889855 0.530 rs4889863 chr17:78550468 C/T cg16591659 chr17:78472290 NA -0.35 -5.75 -0.33 2.43e-8 Fractional excretion of uric acid; CESC cis rs6570726 0.967 rs365515 chr6:145802833 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -10.43 -0.54 1.41e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg16743903 chr16:89593216 SPG7 -0.43 -5.35 -0.31 1.93e-7 Multiple myeloma (IgH translocation); CESC cis rs9291683 0.538 rs11727199 chr4:10036190 C/T cg11266682 chr4:10021025 SLC2A9 0.67 12.99 0.62 3.52e-30 Bone mineral density; CESC cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg06212747 chr3:49208901 KLHDC8B 0.66 8.74 0.47 2.71e-16 Parkinson's disease; CESC cis rs7927771 0.524 rs7116346 chr11:47883880 G/A cg18512352 chr11:47633146 NA -0.36 -5.59 -0.32 5.72e-8 Subjective well-being; CESC cis rs1847202 0.787 rs13071878 chr3:72951084 G/A cg25664220 chr3:72788482 NA -0.39 -5.64 -0.33 4.29e-8 Motion sickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16592623 chr1:181057846 IER5 0.6 6.98 0.39 2.3e-11 Gut microbiome composition (summer); CESC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.68 9.0 0.48 4.4e-17 Total body bone mineral density; CESC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.06 0.4 1.47e-11 Bipolar disorder; CESC trans rs17685 0.712 rs6954569 chr7:75738885 T/A cg19862616 chr7:65841803 NCRNA00174 0.83 11.96 0.59 1.23e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2836974 0.897 rs2776308 chr21:40715175 A/G cg11890956 chr21:40555474 PSMG1 1.02 15.6 0.69 2.21e-39 Cognitive function; CESC cis rs11230563 0.501 rs599856 chr11:60818176 G/A cg10158843 chr11:60776172 CD6 -0.36 -5.37 -0.31 1.69e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs2228479 0.850 rs1800355 chr16:89813194 C/T cg14709524 chr16:89940631 TCF25 0.93 6.9 0.39 3.78e-11 Skin colour saturation; CESC cis rs7524258 0.868 rs8179413 chr1:7267729 T/G cg07173049 chr1:7289937 CAMTA1 0.45 6.65 0.38 1.67e-10 Tourette's syndrome or obsessive-compulsive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18752785 chr20:3996394 RNF24 0.57 6.08 0.35 4.17e-9 Gut microbiome composition (summer); CESC cis rs6693567 0.545 rs11205382 chr1:150442466 G/A cg09579323 chr1:150459698 TARS2 -0.47 -5.95 -0.34 8.27e-9 Migraine; CESC cis rs698833 0.780 rs2005203 chr2:44541725 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.49 6.06 0.35 4.77e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12541635 0.966 rs6469028 chr8:107014552 C/T cg10147462 chr8:107024639 NA 0.42 5.88 0.34 1.24e-8 Age of smoking initiation; CESC cis rs4835473 0.712 rs12509607 chr4:144658047 C/T cg25736465 chr4:144833511 NA -0.33 -5.11 -0.3 6.26e-7 Immature fraction of reticulocytes; CESC cis rs8062405 0.754 rs151179 chr16:28487056 A/G cg08761264 chr16:28874980 SH2B1 -0.45 -5.38 -0.31 1.63e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4919087 0.683 rs1687372 chr10:98978185 A/T cg25902810 chr10:99078978 FRAT1 -0.5 -5.66 -0.33 4.02e-8 Monocyte count; CESC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg18404041 chr3:52824283 ITIH1 -0.42 -6.98 -0.39 2.35e-11 Bipolar disorder; CESC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg14393609 chr7:65229607 NA -0.48 -6.7 -0.38 1.22e-10 Calcium levels; CESC trans rs11039798 0.764 rs1121450 chr11:48897476 C/T cg15704280 chr7:45808275 SEPT13 0.7 6.55 0.37 3.06e-10 Axial length; CESC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -5.7 -0.33 3.12e-8 Extrinsic epigenetic age acceleration; CESC cis rs2652822 0.525 rs12148434 chr15:63510114 A/G cg02713581 chr15:63449717 RPS27L 0.49 6.35 0.36 9.23e-10 Metabolic traits; CESC cis rs3008870 0.755 rs2815360 chr1:67494458 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.61 7.91 0.44 7.21e-14 Lymphocyte percentage of white cells; CESC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg23708337 chr7:1209742 NA 0.52 5.31 0.31 2.35e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg03757819 chr2:191002320 C2orf88 0.39 6.07 0.35 4.4e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2708240 0.875 rs2710120 chr7:147572711 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.33 -5.58 -0.32 5.99e-8 QT interval (drug interaction); CESC cis rs9902453 0.765 rs2628191 chr17:28051140 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.76 -10.15 -0.53 1.14e-20 Coffee consumption (cups per day); CESC cis rs72945132 0.882 rs12274436 chr11:70132204 T/C cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs12249377 0.519 rs35987367 chr10:92591992 C/T cg14313238 chr10:92632228 RPP30 0.42 5.1 0.3 6.45e-7 White matter microstructure (global fractional anisotropy); CESC cis rs4711336 0.935 rs754404 chr6:33664730 T/C cg14003231 chr6:33640908 ITPR3 0.31 5.41 0.32 1.45e-7 Height; CESC trans rs2764766 0.721 rs245195 chr5:127187017 C/T cg15764593 chr10:829463 NA -0.4 -6.19 -0.36 2.3e-9 Schizophrenia; CESC cis rs3768617 0.510 rs4652776 chr1:183091920 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs7264396 0.635 rs6058366 chr20:34512172 A/G cg17201900 chr20:34330562 RBM39 0.49 5.13 0.3 5.54e-7 Total cholesterol levels; CESC cis rs6570726 0.967 rs6903252 chr6:145922777 A/G cg05347473 chr6:146136440 FBXO30 0.46 6.12 0.35 3.32e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs1941023 0.606 rs3825020 chr11:60184191 G/A cg08716584 chr11:60157161 MS4A7 -0.43 -6.34 -0.36 1.01e-9 Congenital heart disease (maternal effect); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25804860 chr16:47178250 NETO2 0.46 6.13 0.35 3.14e-9 Gut microbiota (bacterial taxa); CESC cis rs17253792 0.822 rs75232282 chr14:56067290 G/C cg01858014 chr14:56050164 KTN1 -0.88 -7.15 -0.4 8.55e-12 Putamen volume; CESC cis rs6831352 0.879 rs7672728 chr4:100055173 A/G cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs4555082 0.874 rs11625098 chr14:105756891 A/G cg06808227 chr14:105710500 BRF1 -0.5 -5.33 -0.31 2.09e-7 Mean platelet volume;Platelet distribution width; CESC cis rs72781680 1.000 rs7588286 chr2:24071427 A/G cg20701182 chr2:24300061 SF3B14 0.62 5.6 0.33 5.24e-8 Lymphocyte counts; CESC cis rs6547741 0.816 rs10201652 chr2:27874332 A/C cg27432699 chr2:27873401 GPN1 -0.55 -7.99 -0.44 4.19e-14 Oral cavity cancer; CESC cis rs2072499 0.750 rs909269 chr1:156192028 C/T cg25208724 chr1:156163844 SLC25A44 0.91 11.22 0.57 3.58e-24 Testicular germ cell tumor; CESC cis rs9399135 0.967 rs13191501 chr6:135366880 T/C cg22676075 chr6:135203613 NA 0.5 7.06 0.4 1.49e-11 Red blood cell count; CESC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg19257562 chr1:2043853 PRKCZ 0.33 5.43 0.32 1.25e-7 Height; CESC trans rs7618501 0.540 rs11130241 chr3:50131459 A/T cg21659725 chr3:3221576 CRBN -0.52 -7.23 -0.41 5.32e-12 Intelligence (multi-trait analysis); CESC trans rs11098499 0.908 rs1002152 chr4:120273387 C/A cg25214090 chr10:38739885 LOC399744 0.68 9.28 0.5 6.46e-18 Corneal astigmatism; CESC cis rs6570726 1.000 rs373778 chr6:145873252 C/T cg23711669 chr6:146136114 FBXO30 0.77 11.24 0.57 3.15e-24 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01345365 chr2:12163619 NA -0.6 -7.62 -0.42 4.45e-13 Gut microbiome composition (summer); CESC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg19163074 chr7:65112434 INTS4L2 0.43 5.49 0.32 9.49e-8 Aortic root size; CESC cis rs6695640 0.820 rs6702471 chr1:17752873 A/C cg01904812 chr1:17746340 RCC2 0.35 5.06 0.3 8.01e-7 Mean platelet volume; CESC cis rs4946717 0.740 rs9480634 chr6:106468486 C/T cg02270332 chr6:106475062 NA 0.31 5.33 0.31 2.1e-7 Inflammatory bowel disease; CESC cis rs2816062 1.000 rs2816062 chr1:18903902 G/A cg18795169 chr1:18902165 NA -0.88 -15.93 -0.7 1.6e-40 Urate levels in lean individuals; CESC cis rs826838 0.904 rs10876086 chr12:39188208 C/A cg26384229 chr12:38710491 ALG10B 0.78 13.13 0.63 1.09e-30 Heart rate; CESC cis rs76419734 0.510 rs6820671 chr4:106613821 A/G cg24545054 chr4:106630052 GSTCD;INTS12 0.72 9.2 0.49 1.12e-17 Post bronchodilator FEV1; CESC cis rs7973683 0.541 rs57078519 chr12:124388784 G/A cg00084347 chr12:124393913 DNAH10 0.29 6.06 0.35 4.73e-9 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs12477438 1.000 rs6542873 chr2:99824965 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -7.59 -0.42 5.31e-13 Chronic sinus infection; CESC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg11494091 chr17:61959527 GH2 0.72 12.32 0.6 7.12e-28 Prudent dietary pattern; CESC cis rs372883 0.648 rs382732 chr21:30719010 A/G cg08807101 chr21:30365312 RNF160 0.44 5.23 0.31 3.41e-7 Pancreatic cancer; CESC cis rs17376456 0.569 rs1026279 chr5:93209581 C/A cg25358565 chr5:93447407 FAM172A -0.72 -7.65 -0.43 3.63e-13 Diabetic retinopathy; CESC cis rs1572438 0.896 rs9405366 chr6:858296 A/C cg13447295 chr6:887704 NA -0.38 -5.12 -0.3 5.86e-7 Aging; CESC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg19729930 chr2:74357872 NA 0.84 11.42 0.57 8.06e-25 Gestational age at birth (maternal effect); CESC cis rs1707322 0.686 rs2152078 chr1:46055600 C/T cg06784218 chr1:46089804 CCDC17 -0.41 -7.11 -0.4 1.07e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3820928 0.874 rs12614648 chr2:227785535 G/A cg11843606 chr2:227700838 RHBDD1 -0.49 -6.59 -0.38 2.33e-10 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19758054 chr2:176032603 ATF2;MIR933 0.55 6.38 0.36 7.92e-10 Gut microbiome composition (summer); CESC cis rs3126085 0.877 rs2338431 chr1:152169305 A/G cg03465714 chr1:152285911 FLG -0.47 -5.68 -0.33 3.59e-8 Atopic dermatitis; CESC cis rs959260 1.000 rs6501786 chr17:73378775 A/T cg20590849 chr17:73267439 MIF4GD 0.56 6.65 0.38 1.69e-10 Systemic lupus erythematosus; CESC cis rs317689 0.819 rs317677 chr12:69691806 G/A cg20891283 chr12:69753455 YEATS4 0.47 5.04 0.3 8.79e-7 Response to diuretic therapy; CESC cis rs17376456 0.877 rs13153245 chr5:93374891 G/A cg25358565 chr5:93447407 FAM172A 1.11 11.1 0.56 9.57e-24 Diabetic retinopathy; CESC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg07414643 chr4:187882934 NA 0.57 8.41 0.46 2.53e-15 Lobe attachment (rater-scored or self-reported); CESC cis rs265548 0.608 rs36690 chr19:17910483 C/T cg00024989 chr19:17902242 NA 0.46 7.95 0.44 5.43e-14 Tumor biomarkers; CESC cis rs6674176 0.660 rs2108202 chr1:44395786 A/G cg12908607 chr1:44402522 ARTN 0.49 7.33 0.41 2.8e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4589502 0.800 rs4776855 chr15:67202075 T/C cg12317470 chr15:67143691 NA -0.71 -8.51 -0.46 1.35e-15 Lung cancer (smoking interaction); CESC cis rs6500602 0.727 rs6500607 chr16:4503631 C/T cg08645402 chr16:4508243 NA 0.54 8.54 0.46 1.08e-15 Schizophrenia; CESC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg16988262 chr1:15930761 NA 0.32 5.23 0.31 3.49e-7 Systolic blood pressure; CESC cis rs3020736 0.500 rs8143153 chr22:42515637 G/C cg04733989 chr22:42467013 NAGA -0.83 -12.55 -0.61 1.18e-28 Autism spectrum disorder or schizophrenia; CESC cis rs7799006 0.634 rs34502289 chr7:2311266 G/A cg08027265 chr7:2291960 NA -0.6 -10.22 -0.53 6.78e-21 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04322344 chr3:131221642 MRPL3 0.47 6.12 0.35 3.32e-9 Gut microbiota (bacterial taxa); CESC trans rs7615952 0.641 rs4422257 chr3:125774363 A/G cg07211511 chr3:129823064 LOC729375 -0.6 -6.66 -0.38 1.53e-10 Blood pressure (smoking interaction); CESC cis rs8114671 0.836 rs6060165 chr20:33619480 A/C cg06115741 chr20:33292138 TP53INP2 -0.44 -5.37 -0.31 1.71e-7 Height; CESC cis rs9549260 0.564 rs6563844 chr13:41298190 T/C cg21288729 chr13:41239152 FOXO1 0.59 7.35 0.41 2.51e-12 Red blood cell count; CESC trans rs7615952 0.641 rs66520539 chr3:125780374 G/A cg07211511 chr3:129823064 LOC729375 -0.59 -6.53 -0.37 3.37e-10 Blood pressure (smoking interaction); CESC cis rs941873 0.836 rs6480931 chr10:81108482 T/C cg08514558 chr10:81106712 PPIF 0.34 5.77 0.33 2.21e-8 Height; CESC cis rs854765 0.547 rs2955377 chr17:17932818 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.43 0.37 5.86e-10 Total body bone mineral density; CESC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg04025307 chr7:1156635 C7orf50 0.41 5.68 0.33 3.49e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17376456 0.569 rs7701114 chr5:93096028 T/C cg25358565 chr5:93447407 FAM172A 0.68 7.25 0.41 4.53e-12 Diabetic retinopathy; CESC cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg06212747 chr3:49208901 KLHDC8B 0.66 8.74 0.47 2.71e-16 Parkinson's disease; CESC cis rs2204008 0.846 rs2030416 chr12:38465118 A/G cg26384229 chr12:38710491 ALG10B -0.64 -9.53 -0.51 1.07e-18 Bladder cancer; CESC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.78 10.59 0.55 4.33e-22 Height; CESC cis rs523522 0.962 rs651627 chr12:121009198 C/T cg27279351 chr12:120934652 DYNLL1 0.69 8.91 0.48 8.41e-17 High light scatter reticulocyte count; CESC cis rs6570726 0.846 rs372904 chr6:145887425 T/C cg05347473 chr6:146136440 FBXO30 0.54 7.09 0.4 1.24e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08273200 chr1:39338480 MYCBP 0.5 6.38 0.36 7.99e-10 Gut microbiota (bacterial taxa); CESC cis rs4835473 0.897 rs56324738 chr4:144657450 A/T cg25736465 chr4:144833511 NA -0.32 -5.07 -0.3 7.49e-7 Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13662628 chr9:127572244 OLFML2A -0.51 -6.1 -0.35 3.78e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05117058 chr20:3209220 SLC4A11 0.47 6.46 0.37 5.13e-10 Fibrinogen levels; CESC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.46 0.37 4.98e-10 Bipolar disorder; CESC cis rs992157 0.710 rs12996912 chr2:219110555 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.67 9.37 0.5 3.39e-18 Colorectal cancer; CESC cis rs35110281 0.805 rs2838319 chr21:44991901 A/G cg04455712 chr21:45112962 RRP1B 0.37 5.48 0.32 1.01e-7 Mean corpuscular volume; CESC trans rs12310956 0.532 rs11052930 chr12:33964824 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.35 0.46 3.79e-15 Morning vs. evening chronotype; CESC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg04944784 chr2:26401820 FAM59B -0.8 -8.93 -0.48 7.17e-17 Gut microbiome composition (summer); CESC trans rs274437 0.739 rs12197788 chr6:104791156 G/A cg24439334 chr1:2345374 PEX10 0.55 6.0 0.35 6.49e-9 Colonoscopy-negative controls vs population controls; CESC cis rs8013055 0.846 rs10147392 chr14:105978537 T/G cg23356831 chr14:105996513 TMEM121 0.37 5.27 0.31 2.82e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg27165867 chr14:105738592 BRF1 -0.48 -5.16 -0.3 4.75e-7 Mean platelet volume;Platelet distribution width; CESC cis rs3820068 0.581 rs72645889 chr1:15930251 T/G cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg08392591 chr16:89556376 ANKRD11 0.58 7.87 0.44 8.84e-14 Multiple myeloma (IgH translocation); CESC cis rs7520050 0.966 rs7540325 chr1:46338217 A/T cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.4e-7 Red blood cell count;Reticulocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06014083 chr17:81052928 NA 0.45 6.21 0.36 2.09e-9 Fibrinogen levels; CESC cis rs6429082 0.714 rs184108 chr1:235646160 A/G cg26050004 chr1:235667680 B3GALNT2 0.62 7.83 0.43 1.19e-13 Adiposity; CESC cis rs7772486 0.875 rs1331644 chr6:146398660 T/C cg23711669 chr6:146136114 FBXO30 0.82 12.45 0.61 2.54e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7296418 0.518 rs28825193 chr12:123878262 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.33 -5.07 -0.3 7.35e-7 Platelet count; CESC trans rs6089829 0.962 rs7267951 chr20:61665979 A/G cg23505145 chr19:12996616 KLF1 0.52 6.8 0.39 6.85e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs9902453 0.935 rs7220151 chr17:28334710 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.83 -0.43 1.15e-13 Coffee consumption (cups per day); CESC cis rs7208859 0.524 rs11653098 chr17:29122501 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg06022373 chr22:39101656 GTPBP1 -0.88 -13.18 -0.63 7.81e-31 Menopause (age at onset); CESC cis rs2242663 0.581 rs2511224 chr11:66262606 T/C cg04006266 chr11:66300458 BBS1 -0.35 -5.33 -0.31 2.08e-7 Bipolar disorder; CESC cis rs10465746 1.000 rs10465746 chr1:84387632 T/G cg10977910 chr1:84465055 TTLL7 0.48 6.46 0.37 4.85e-10 Obesity-related traits; CESC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg11764359 chr7:65958608 NA 0.81 11.84 0.59 3.02e-26 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08168689 chr14:76455272 C14orf179 -0.6 -6.34 -0.36 9.98e-10 Gut microbiome composition (summer); CESC cis rs950169 0.922 rs17531523 chr15:85132449 C/G cg17507749 chr15:85114479 UBE2QP1 0.54 6.09 0.35 3.99e-9 Schizophrenia; CESC cis rs250677 0.652 rs168751 chr5:148438264 C/T cg18129178 chr5:148520854 ABLIM3 -0.54 -5.4 -0.31 1.48e-7 Breast cancer; CESC cis rs11098499 0.865 rs10032158 chr4:120391632 C/T cg09307838 chr4:120376055 NA 0.94 13.94 0.65 1.68e-33 Corneal astigmatism; CESC cis rs11792861 0.619 rs2289481 chr9:111712924 G/C cg13535736 chr9:111863775 C9orf5 -0.39 -5.72 -0.33 2.92e-8 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24335355 chr19:41770635 HNRNPUL1 0.54 6.52 0.37 3.53e-10 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs9429186 chr1:46539687 C/T cg05343316 chr1:45956843 TESK2 -0.44 -5.26 -0.31 2.94e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2932538 0.961 rs2932539 chr1:113215786 A/G cg22162597 chr1:113214053 CAPZA1 -0.57 -7.2 -0.4 6.14e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs3820928 0.874 rs4234062 chr2:227819050 C/A cg05526886 chr2:227700861 RHBDD1 -0.4 -5.1 -0.3 6.52e-7 Pulmonary function; CESC cis rs9388451 0.626 rs2875881 chr6:126072853 C/G cg05901451 chr6:126070800 HEY2 -0.62 -9.3 -0.5 5.52e-18 Brugada syndrome; CESC cis rs2070488 0.775 rs2186457 chr3:38553965 A/G cg24069376 chr3:38537580 EXOG 0.32 5.55 0.32 6.79e-8 Electrocardiographic conduction measures; CESC cis rs722599 0.599 rs8003660 chr14:75227098 T/C cg08847533 chr14:75593920 NEK9 0.48 5.88 0.34 1.25e-8 IgG glycosylation; CESC cis rs3126085 0.935 rs12063165 chr1:152176357 C/T cg26876637 chr1:152193138 HRNR 0.47 5.4 0.31 1.49e-7 Atopic dermatitis; CESC cis rs4132509 1.000 rs12403316 chr1:243956903 C/T cg21452805 chr1:244014465 NA 0.5 6.15 0.35 2.78e-9 RR interval (heart rate); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15692031 chr10:93683614 BTAF1 0.58 6.46 0.37 5.07e-10 Gut microbiome composition (summer); CESC cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg10523679 chr1:76189770 ACADM -0.87 -13.69 -0.64 1.21e-32 Blood metabolite levels;Acylcarnitine levels; CESC cis rs8070624 0.543 rs11078409 chr17:17876296 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.68 9.67 0.51 3.79e-19 Total body bone mineral density; CESC cis rs4315565 0.688 rs6546478 chr2:69282132 C/T cg12800200 chr2:69260302 ANTXR1 -0.38 -5.34 -0.31 1.97e-7 Height; CESC cis rs2933343 0.700 rs1680778 chr3:128614185 A/C cg24203234 chr3:128598194 ACAD9 0.38 5.04 0.3 8.69e-7 IgG glycosylation; CESC cis rs9828933 0.882 rs3816156 chr3:63999712 A/T cg16258503 chr3:63850278 ATXN7;THOC7 -0.59 -5.97 -0.34 7.67e-9 Type 2 diabetes; CESC cis rs17253792 0.822 rs75560658 chr14:56079896 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg12963246 chr6:28129442 ZNF389 0.59 7.7 0.43 2.7e-13 Depression; CESC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg08888203 chr3:10149979 C3orf24 0.46 5.49 0.32 9.51e-8 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05310613 chr6:139456890 HECA 0.6 7.22 0.41 5.44e-12 Gut microbiome composition (summer); CESC cis rs2573652 0.723 rs4577068 chr15:100515959 T/A cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.25 -0.31 3.18e-7 Height; CESC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC trans rs7906315 0.967 rs3814573 chr10:114898093 C/T cg15127867 chr2:128457218 SFT2D3 -0.42 -6.06 -0.35 4.62e-9 Breast cancer; CESC cis rs2732480 0.577 rs2732479 chr12:48736260 A/C cg04545296 chr12:48745243 ZNF641 0.44 7.22 0.41 5.44e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg23743428 chr13:21893420 NA -0.39 -6.64 -0.38 1.78e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs10861342 1.000 rs10861356 chr12:105526965 G/T cg23923672 chr12:105501055 KIAA1033 0.73 6.35 0.36 9.44e-10 IgG glycosylation; CESC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg08888203 chr3:10149979 C3orf24 0.47 5.91 0.34 1.05e-8 Alzheimer's disease; CESC cis rs7584330 0.780 rs2292884 chr2:238443226 A/G cg14458575 chr2:238380390 NA 0.56 7.87 0.44 9.06e-14 Prostate cancer; CESC cis rs7945705 0.870 rs10840142 chr11:8906078 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.37 5.97 0.34 7.77e-9 Hemoglobin concentration; CESC cis rs711830 0.576 rs72916141 chr2:177069364 G/T cg13092806 chr2:177043255 NA -0.58 -6.51 -0.37 3.68e-10 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CESC cis rs80130819 0.688 rs6580660 chr12:48588112 T/C cg05342945 chr12:48394962 COL2A1 -0.5 -5.85 -0.34 1.43e-8 Prostate cancer; CESC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg04944784 chr2:26401820 FAM59B -0.67 -7.04 -0.4 1.65e-11 Gut microbiome composition (summer); CESC cis rs7633770 0.664 rs7373994 chr3:46701114 C/G cg11219411 chr3:46661640 NA -0.37 -6.04 -0.35 5.14e-9 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04084132 chr16:84538323 KIAA1609 0.49 6.22 0.36 1.96e-9 Gut microbiota (bacterial taxa); CESC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg10691866 chr7:65817282 TPST1 -0.33 -5.42 -0.32 1.34e-7 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11668638 chr6:42952412 PPP2R5D 0.48 6.27 0.36 1.45e-9 Gut microbiota (bacterial taxa); CESC cis rs2236918 0.710 rs1776174 chr1:242031839 G/T cg17736920 chr1:242011382 EXO1 0.55 6.86 0.39 4.91e-11 Menopause (age at onset); CESC cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9549367 0.713 rs3024764 chr13:113824314 A/G cg00898013 chr13:113819073 PROZ -0.48 -6.75 -0.38 9.35e-11 Platelet distribution width; CESC cis rs1355223 0.902 rs2185700 chr11:34724204 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.21 -0.36 2.02e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg15145296 chr3:125709740 NA -0.52 -5.47 -0.32 1.06e-7 Blood pressure (smoking interaction); CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg18337363 chr3:52569053 NT5DC2 0.34 6.55 0.37 2.99e-10 Electroencephalogram traits; CESC cis rs2191566 0.540 rs391267 chr19:44492487 C/T cg20607764 chr19:44506953 ZNF230 0.45 5.66 0.33 3.92e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs1568889 1.000 rs78140392 chr11:28203231 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.74 9.35 0.5 3.75e-18 Bipolar disorder; CESC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.38e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg23711669 chr6:146136114 FBXO30 1.01 15.52 0.69 4.59e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg04166393 chr7:2884313 GNA12 0.6 7.6 0.42 5.22e-13 Height; CESC cis rs1538970 1.000 rs17395553 chr1:45864761 C/T cg24296786 chr1:45957014 TESK2 -0.42 -5.05 -0.3 8.43e-7 Platelet count; CESC cis rs7647973 0.600 rs12631989 chr3:49273996 C/T cg06212747 chr3:49208901 KLHDC8B 0.7 10.45 0.54 1.24e-21 Menarche (age at onset); CESC cis rs6433857 0.594 rs17364750 chr2:181524361 C/G cg23363182 chr2:181467187 NA -0.47 -6.45 -0.37 5.23e-10 Body mass index; CESC cis rs7605827 0.866 rs6745922 chr2:15537931 G/C cg19274914 chr2:15703543 NA 0.36 6.45 0.37 5.17e-10 Educational attainment (years of education); CESC cis rs3857536 0.611 rs7748258 chr6:66932840 A/G cg07460842 chr6:66804631 NA -0.42 -5.36 -0.31 1.8e-7 Blood trace element (Cu levels); CESC cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs62229266 0.839 rs11088335 chr21:37470335 C/T cg12218747 chr21:37451666 NA -0.48 -6.77 -0.38 8.03e-11 Mitral valve prolapse; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19275838 chr7:45115588 CCM2 -0.57 -6.27 -0.36 1.45e-9 Gut microbiome composition (summer); CESC cis rs4595586 0.679 rs11169992 chr12:39317207 C/T cg26384229 chr12:38710491 ALG10B 0.41 6.09 0.35 3.94e-9 Morning vs. evening chronotype; CESC cis rs7546094 1.000 rs3103450 chr1:113197730 G/A cg22162597 chr1:113214053 CAPZA1 -0.39 -6.08 -0.35 4.18e-9 Platelet distribution width; CESC cis rs7312933 0.558 rs11181463 chr12:42763636 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.47 6.03 0.35 5.41e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs826838 1.000 rs4575342 chr12:38663831 G/A cg13010199 chr12:38710504 ALG10B 0.59 8.31 0.45 4.93e-15 Heart rate; CESC cis rs881375 0.933 rs4837804 chr9:123705304 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 5.24 0.31 3.35e-7 Rheumatoid arthritis; CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg07308232 chr7:1071921 C7orf50 -0.42 -5.62 -0.33 4.77e-8 Longevity;Endometriosis; CESC cis rs2243480 1.000 rs35735127 chr7:65300423 G/T cg13147721 chr7:65941812 NA -0.84 -8.42 -0.46 2.36e-15 Diabetic kidney disease; CESC cis rs6690583 0.623 rs893620 chr1:85425821 T/C cg11262906 chr1:85462892 MCOLN2 0.54 5.1 0.3 6.51e-7 Serum sulfate level; CESC cis rs854765 0.583 rs4925126 chr17:17798633 C/T cg09796270 chr17:17721594 SREBF1 0.41 5.8 0.34 1.86e-8 Total body bone mineral density; CESC trans rs801193 1.000 rs1553610 chr7:66197233 T/C cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC cis rs17401966 0.838 rs4846209 chr1:10322054 G/A cg15208524 chr1:10270712 KIF1B 0.39 5.14 0.3 5.37e-7 Hepatocellular carcinoma; CESC cis rs2439831 1.000 rs2467739 chr15:43740196 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.8 11.71 0.58 8.62e-26 Lung cancer in ever smokers; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10446143 chr21:44394730 PKNOX1 0.48 6.43 0.37 5.86e-10 Systemic lupus erythematosus; CESC cis rs6089829 0.692 rs6122349 chr20:61664096 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 6.17 0.35 2.61e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs9467711 0.606 rs12174639 chr6:26373121 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -7.07 -0.4 1.4e-11 Autism spectrum disorder or schizophrenia; CESC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg23048001 chr7:2026167 MAD1L1 0.42 5.43 0.32 1.25e-7 Bipolar disorder and schizophrenia; CESC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg05890377 chr2:74357713 NA 0.66 8.0 0.44 3.85e-14 Gestational age at birth (maternal effect); CESC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg07507251 chr3:52567010 NT5DC2 -0.35 -5.98 -0.34 7.15e-9 Bipolar disorder; CESC cis rs4722166 0.630 rs13311199 chr7:22789793 A/C cg26061582 chr7:22766209 IL6 0.5 5.47 0.32 1.04e-7 Lung cancer; CESC cis rs6495122 0.651 rs11636952 chr15:75114322 T/C cg14664628 chr15:75095509 CSK -0.82 -12.94 -0.62 5.1e-30 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs3126085 0.799 rs11589532 chr1:152176539 G/A cg03465714 chr1:152285911 FLG 0.47 5.55 0.32 6.93e-8 Atopic dermatitis; CESC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg22535103 chr8:58192502 C8orf71 -0.81 -9.14 -0.49 1.73e-17 Developmental language disorder (linguistic errors); CESC cis rs854765 0.583 rs8078138 chr17:17811251 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.36 0.36 8.89e-10 Total body bone mineral density; CESC cis rs7647973 1.000 rs1982861 chr3:49577665 A/G cg07636037 chr3:49044803 WDR6 0.72 10.34 0.54 2.84e-21 Menarche (age at onset); CESC cis rs644799 1.000 rs3177463 chr11:95502128 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.36 0.5 3.61e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg27125505 chr17:43679177 LOC644172 0.48 6.39 0.37 7.63e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg19163074 chr7:65112434 INTS4L2 -0.42 -5.26 -0.31 2.93e-7 Aortic root size; CESC cis rs116095464 0.558 rs56043030 chr5:220917 A/G cg22857025 chr5:266934 NA -1.27 -18.89 -0.76 5.51e-51 Breast cancer; CESC cis rs7809950 0.834 rs2712199 chr7:107140239 A/G cg23024343 chr7:107201750 COG5 -0.42 -6.0 -0.35 6.33e-9 Coronary artery disease; CESC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg24562669 chr7:97807699 LMTK2 0.53 7.79 0.43 1.55e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.71 -0.38 1.17e-10 Electroencephalogram traits; CESC cis rs62432291 0.681 rs402388 chr6:159654994 A/C cg14500486 chr6:159655392 FNDC1 -0.62 -6.21 -0.36 2.04e-9 Joint mobility (Beighton score); CESC trans rs10808739 0.660 rs4258041 chr8:65701101 C/G cg19896198 chr1:12123262 TNFRSF8 0.36 6.02 0.35 5.91e-9 HIV-1 susceptibility; CESC cis rs6460942 0.597 rs13221702 chr7:12519076 A/G cg02935154 chr7:12443704 VWDE 0.52 5.22 0.31 3.57e-7 Coronary artery disease; CESC cis rs7520050 0.808 rs11211195 chr1:46282295 T/C cg03146154 chr1:46216737 IPP -0.47 -6.19 -0.36 2.34e-9 Red blood cell count;Reticulocyte count; CESC cis rs12458462 0.892 rs2242175 chr18:77464406 G/A cg23301140 chr18:77439876 CTDP1 0.57 7.65 0.43 3.62e-13 Monocyte count; CESC cis rs2204008 0.688 rs12824232 chr12:38175901 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs367943 1.000 rs348955 chr5:112821643 C/T cg12552261 chr5:112820674 MCC -0.63 -8.02 -0.44 3.43e-14 Type 2 diabetes; CESC cis rs9486719 1.000 rs12190397 chr6:97036465 G/A cg18709589 chr6:96969512 KIAA0776 -0.5 -5.44 -0.32 1.21e-7 Migraine;Coronary artery disease; CESC cis rs1707322 0.752 rs28568986 chr1:46207743 C/T cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10411936 0.962 rs10402422 chr19:16475388 G/A cg10248733 chr19:16607483 C19orf44;CALR3 0.54 6.37 0.36 8.36e-10 White blood cell count;Multiple sclerosis; CESC cis rs8020095 0.571 rs8012776 chr14:67587878 C/T cg19548862 chr14:67692701 FAM71D -0.49 -6.12 -0.35 3.34e-9 Depression (quantitative trait); CESC cis rs34779708 0.966 rs4934725 chr10:35398236 T/C cg03585969 chr10:35415529 CREM 0.77 10.1 0.53 1.71e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6460942 0.597 rs62449509 chr7:12515013 C/T cg06484146 chr7:12443880 VWDE -0.71 -7.63 -0.42 4.31e-13 Coronary artery disease; CESC cis rs6500602 0.702 rs56895104 chr16:4548132 G/A cg08645402 chr16:4508243 NA 0.56 9.21 0.49 1.02e-17 Schizophrenia; CESC cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg03433033 chr1:76189801 ACADM 0.68 8.11 0.45 1.9e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2635047 0.967 rs2247784 chr18:44746997 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.47 6.32 0.36 1.1e-9 Educational attainment; CESC cis rs72781680 0.752 rs72796114 chr2:23906133 C/G cg20701182 chr2:24300061 SF3B14 0.79 6.83 0.39 5.68e-11 Lymphocyte counts; CESC cis rs35146811 0.961 rs11771139 chr7:99736059 C/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.12 0.3 5.99e-7 Coronary artery disease; CESC cis rs10242455 0.557 rs34943973 chr7:99032517 G/A cg18809830 chr7:99032528 PTCD1 -0.95 -6.42 -0.37 6.27e-10 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26254453 chr1:46152494 TMEM69;GPBP1L1 0.63 7.18 0.4 6.89e-12 Gut microbiome composition (summer); CESC cis rs7191439 0.858 rs7205626 chr16:88780472 T/C cg02389323 chr16:88786976 FAM38A 0.86 7.42 0.41 1.58e-12 Plateletcrit; CESC cis rs4588572 0.686 rs34262593 chr5:77666427 T/C cg11547950 chr5:77652471 NA 0.43 5.45 0.32 1.14e-7 Triglycerides; CESC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg13866156 chr1:1669148 SLC35E2 -0.5 -6.66 -0.38 1.58e-10 Body mass index; CESC cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.97 0.34 7.58e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6570726 0.846 rs439035 chr6:145887990 G/C cg05347473 chr6:146136440 FBXO30 0.49 6.51 0.37 3.84e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg00129232 chr17:37814104 STARD3 0.57 7.67 0.43 3.29e-13 Glomerular filtration rate (creatinine); CESC cis rs9303401 0.538 rs8078280 chr17:56473132 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.9 10.99 0.56 2.11e-23 Cognitive test performance; CESC cis rs1580019 0.587 rs1597555 chr7:32546118 T/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.39 0.37 7.42e-10 Cognitive ability; CESC cis rs9399135 0.967 rs9376077 chr6:135299713 C/G cg22676075 chr6:135203613 NA 0.51 7.02 0.4 1.84e-11 Red blood cell count; CESC cis rs3733585 0.699 rs7435196 chr4:9967556 A/C cg11266682 chr4:10021025 SLC2A9 -0.58 -10.97 -0.56 2.51e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9393777 0.588 rs3799380 chr6:26467182 C/T cg12826209 chr6:26865740 GUSBL1 -0.62 -7.76 -0.43 1.81e-13 Intelligence (multi-trait analysis); CESC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg12963246 chr6:28129442 ZNF389 0.4 5.48 0.32 9.73e-8 Parkinson's disease; CESC cis rs2742234 0.541 rs1059484 chr10:43679800 T/G cg15436174 chr10:43711423 RASGEF1A -0.5 -5.84 -0.34 1.5e-8 Hirschsprung disease; CESC cis rs36051895 0.589 rs10491650 chr9:5203054 C/T cg02405213 chr9:5042618 JAK2 0.47 5.63 0.33 4.6e-8 Pediatric autoimmune diseases; CESC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg10691866 chr7:65817282 TPST1 -0.35 -5.95 -0.34 8.41e-9 Aortic root size; CESC cis rs10129255 0.500 rs6576226 chr14:107186374 G/A cg07958169 chr14:107095056 NA -0.54 -8.49 -0.46 1.51e-15 Kawasaki disease; CESC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg27286337 chr10:134555280 INPP5A 0.65 7.62 0.42 4.39e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs28489187 0.706 rs233091 chr1:85823044 G/C cg16011679 chr1:85725395 C1orf52 0.47 5.45 0.32 1.14e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs3749237 0.595 rs1464568 chr3:49458266 G/A cg03060546 chr3:49711283 APEH 0.76 11.69 0.58 9.43e-26 Resting heart rate; CESC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg08470875 chr2:26401718 FAM59B -0.73 -7.97 -0.44 4.87e-14 Gut microbiome composition (summer); CESC cis rs7264396 0.563 rs2425131 chr20:34337074 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.71 -0.55 1.83e-22 Total cholesterol levels; CESC cis rs2073300 0.609 rs2281434 chr20:23378101 C/A cg12062639 chr20:23401060 NAPB 1.07 8.85 0.48 1.29e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1986734 0.576 rs2068063 chr4:77417203 C/T cg20311846 chr4:77356250 SHROOM3 0.27 5.44 0.32 1.2e-7 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg06481639 chr22:41940642 POLR3H 0.64 6.5 0.37 3.91e-10 Vitiligo; CESC cis rs9303401 0.527 rs34835800 chr17:56764990 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.38 0.61 4.37e-28 Cognitive test performance; CESC trans rs2235573 0.551 rs139895 chr22:38397034 A/G cg19894588 chr14:64061835 NA -0.57 -7.55 -0.42 7.06e-13 Glioblastoma;Glioma; CESC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg18876405 chr7:65276391 NA -0.53 -7.25 -0.41 4.64e-12 Aortic root size; CESC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg08736216 chr1:53307985 ZYG11A 0.43 7.24 0.41 4.86e-12 Monocyte count; CESC cis rs778371 0.723 rs1022329 chr2:233591239 T/C cg08000102 chr2:233561755 GIGYF2 0.84 14.62 0.67 6.79e-36 Schizophrenia; CESC cis rs7829975 0.846 rs11779061 chr8:8549432 G/A cg06636001 chr8:8085503 FLJ10661 -0.45 -5.85 -0.34 1.45e-8 Mood instability; CESC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.52 -0.32 8.2e-8 Total body bone mineral density; CESC cis rs10197940 0.624 rs6731486 chr2:152410732 C/T cg06191203 chr2:152266755 RIF1 0.45 5.71 0.33 3.05e-8 Lung cancer; CESC cis rs10465746 0.780 rs12145258 chr1:84401211 G/A cg10977910 chr1:84465055 TTLL7 0.51 6.95 0.39 2.89e-11 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13497155 chr3:50374949 RASSF1 -0.63 -7.03 -0.4 1.71e-11 Gut microbiome composition (summer); CESC cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg01475377 chr6:109611718 NA -0.5 -8.37 -0.46 3.34e-15 Reticulocyte fraction of red cells; CESC cis rs36051895 0.658 rs72699574 chr9:5020089 G/A cg02405213 chr9:5042618 JAK2 -0.5 -5.48 -0.32 9.73e-8 Pediatric autoimmune diseases; CESC cis rs4974559 0.740 rs11933854 chr4:1315172 G/A cg02980000 chr4:1222292 CTBP1 0.64 7.16 0.4 8.08e-12 Systolic blood pressure; CESC cis rs7818688 0.697 rs78802294 chr8:95977974 G/A cg16049864 chr8:95962084 TP53INP1 0.57 5.73 0.33 2.79e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03790324 chr7:76143302 UPK3B 0.52 6.92 0.39 3.33e-11 Fibrinogen levels; CESC cis rs73019876 0.901 rs2666440 chr19:22139345 G/T cg11619707 chr19:22235551 ZNF257 -0.27 -5.11 -0.3 6.12e-7 Testicular germ cell tumor; CESC cis rs8040855 0.627 rs4980357 chr15:85608109 G/T cg08123816 chr15:85640762 PDE8A -0.41 -6.07 -0.35 4.31e-9 Bulimia nervosa; CESC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg07507251 chr3:52567010 NT5DC2 0.4 7.1 0.4 1.14e-11 Bipolar disorder; CESC cis rs2066819 1.000 rs118130855 chr12:56677979 T/A cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs910316 1.000 rs4899546 chr14:75594946 G/C cg11812906 chr14:75593930 NEK9 0.9 15.35 0.69 1.8e-38 Height; CESC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs11676348 0.818 rs7425447 chr2:218980183 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.16 -0.35 2.67e-9 Ulcerative colitis; CESC cis rs9611565 0.879 rs5758307 chr22:41750219 A/G cg03806693 chr22:41940476 POLR3H -0.72 -8.72 -0.47 3.14e-16 Vitiligo; CESC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg20151795 chr6:28129481 ZNF389 0.43 5.46 0.32 1.11e-7 Depression; CESC cis rs11122272 0.735 rs2808583 chr1:231512587 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.25e-13 Hemoglobin concentration; CESC cis rs1784581 0.546 rs1954917 chr6:162447490 C/T cg17173639 chr6:162384350 PARK2 0.61 9.45 0.5 1.87e-18 Itch intensity from mosquito bite; CESC cis rs6748734 1.000 rs3936203 chr2:241834654 C/T cg04034577 chr2:241836375 C2orf54 0.51 8.89 0.48 9.34e-17 Urinary metabolites; CESC cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg26597838 chr10:835615 NA 0.7 6.38 0.36 7.93e-10 Eosinophil percentage of granulocytes; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23187205 chr6:109416245 SESN1;C6orf182 -0.46 -6.18 -0.35 2.45e-9 Height; CESC cis rs875971 0.662 rs448725 chr7:65514628 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.49 -0.32 9.58e-8 Aortic root size; CESC cis rs1707322 0.964 rs7512395 chr1:46361177 G/A cg05343316 chr1:45956843 TESK2 0.49 5.96 0.34 7.98e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1788820 0.917 rs1788785 chr18:21142340 T/C cg14672496 chr18:21087552 C18orf8 0.55 7.43 0.42 1.5e-12 Body mass index; CESC cis rs9488822 0.676 rs12196579 chr6:116351724 G/T cg18764771 chr6:116381957 FRK 0.23 5.71 0.33 3.07e-8 Cholesterol, total;LDL cholesterol; CESC trans rs2749592 0.505 rs7915670 chr10:37870212 T/C cg12057190 chr19:54976211 LENG9;CDC42EP5 -0.42 -6.0 -0.35 6.62e-9 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06854353 chr6:109704291 CD164 -0.55 -6.33 -0.36 1.03e-9 Gut microbiome composition (summer); CESC cis rs4423214 1.000 rs2282621 chr11:71183474 C/T cg24826892 chr11:71159390 DHCR7 0.46 5.24 0.31 3.2e-7 Vitamin D levels; CESC trans rs330071 0.686 rs10087406 chr8:9246598 C/T cg15556689 chr8:8085844 FLJ10661 -0.51 -6.1 -0.35 3.65e-9 Acne (severe); CESC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg26338869 chr17:61819248 STRADA 0.69 9.18 0.49 1.31e-17 Prudent dietary pattern; CESC cis rs11676348 0.755 rs6436026 chr2:218951738 T/A cg00012203 chr2:219082015 ARPC2 -0.52 -6.85 -0.39 5e-11 Ulcerative colitis; CESC cis rs654950 0.807 rs941970 chr1:41990867 G/A cg06885757 chr1:42089581 HIVEP3 -0.44 -6.84 -0.39 5.39e-11 Airway imaging phenotypes; CESC cis rs9527 0.545 rs7100369 chr10:104956218 C/A cg04362960 chr10:104952993 NT5C2 0.44 5.56 0.32 6.74e-8 Arsenic metabolism; CESC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg12667521 chr19:29218732 NA 0.48 6.4 0.37 6.97e-10 Methadone dose in opioid dependence; CESC cis rs6570726 0.791 rs6570693 chr6:145910841 C/T cg05347473 chr6:146136440 FBXO30 0.57 7.44 0.42 1.37e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC trans rs3087243 0.755 rs231735 chr2:204693876 A/C cg01841312 chr10:38069945 NA -0.41 -6.98 -0.39 2.34e-11 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs6570726 0.811 rs375873 chr6:145812371 G/T cg23711669 chr6:146136114 FBXO30 0.78 11.22 0.57 3.67e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs1218582 0.682 rs12046459 chr1:154912017 A/C cg09359103 chr1:154839909 KCNN3 -0.65 -11.98 -0.59 1.01e-26 Prostate cancer; CESC trans rs8056446 0.710 rs8059793 chr16:78189298 A/C cg22855052 chr12:6982535 SPSB2 0.44 6.09 0.35 3.91e-9 Pulmonary function (smoking interaction); CESC cis rs10080237 0.564 rs2490224 chr6:80809833 G/A cg08355045 chr6:80787529 NA 0.34 5.19 0.3 4.19e-7 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; CESC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg13722127 chr7:150037890 RARRES2 0.39 5.29 0.31 2.56e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs12220238 1.000 rs11000912 chr10:75948477 A/C cg19889307 chr10:75911429 ADK;AP3M1 0.59 5.12 0.3 5.78e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg11279151 chr3:101281821 RG9MTD1 -0.45 -5.03 -0.3 8.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7834588 0.523 rs4739023 chr8:63831674 C/G cg20602954 chr8:63776762 NKAIN3 -0.31 -5.29 -0.31 2.61e-7 Response to Vitamin E supplementation; CESC cis rs2296342 0.652 rs2296338 chr6:33630816 G/A cg14003231 chr6:33640908 ITPR3 0.3 5.13 0.3 5.53e-7 Schizophrenia; CESC cis rs7666738 0.830 rs4292342 chr4:98959870 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.47 0.46 1.76e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9488822 0.676 rs1556857 chr6:116325559 T/C cg18764771 chr6:116381957 FRK 0.22 5.44 0.32 1.21e-7 Cholesterol, total;LDL cholesterol; CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg21548813 chr6:291882 DUSP22 -0.73 -9.81 -0.52 1.38e-19 Menopause (age at onset); CESC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg00815214 chr21:47717953 NA 0.43 6.27 0.36 1.49e-9 Testicular germ cell tumor; CESC trans rs35110281 0.807 rs2838328 chr21:45023234 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 6.54 0.37 3.14e-10 Mean corpuscular volume; CESC cis rs2425143 1.000 rs78877130 chr20:34344947 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.67 5.76 0.33 2.31e-8 Blood protein levels; CESC cis rs9911578 1.000 rs2567911 chr17:56734977 A/G cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC cis rs6460942 1.000 rs6970095 chr7:12403840 G/A cg20607287 chr7:12443886 VWDE -0.68 -7.91 -0.44 6.85e-14 Coronary artery disease; CESC cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg05192639 chr6:26864778 GUSBL1 -0.27 -5.11 -0.3 6.25e-7 Intelligence (multi-trait analysis); CESC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg16405210 chr4:1374714 KIAA1530 0.78 10.15 0.53 1.12e-20 Longevity; CESC cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg11752832 chr7:134001865 SLC35B4 0.55 7.22 0.41 5.43e-12 Mean platelet volume; CESC cis rs6542838 0.588 rs4851174 chr2:99530113 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -5.97 -0.34 7.71e-9 Fear of minor pain; CESC cis rs7666738 0.830 rs62318503 chr4:98935479 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2486288 0.656 rs12904150 chr15:45547605 T/C cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.54 -0.37 3.21e-10 Glomerular filtration rate; CESC cis rs7851660 0.935 rs12347191 chr9:100619719 C/T cg13688889 chr9:100608707 NA -0.7 -10.61 -0.55 3.91e-22 Strep throat; CESC cis rs7618501 0.699 rs2777888 chr3:49898000 A/G cg24308560 chr3:49941425 MST1R -0.69 -10.31 -0.54 3.58e-21 Intelligence (multi-trait analysis); CESC cis rs9815354 0.680 rs73073285 chr3:42027566 T/G cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12019576 chr4:154388535 KIAA0922 -0.43 -6.2 -0.36 2.19e-9 Gambling; CESC cis rs72781680 1.000 rs12614452 chr2:24194608 C/T cg08917208 chr2:24149416 ATAD2B 0.94 8.54 0.46 1.09e-15 Lymphocyte counts; CESC cis rs1008375 0.900 rs12650220 chr4:17595365 A/T cg04450456 chr4:17643702 FAM184B 0.36 5.11 0.3 6.31e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10129255 0.518 rs8004895 chr14:107193377 T/C cg07958169 chr14:107095056 NA -0.54 -8.32 -0.45 4.77e-15 Kawasaki disease; CESC cis rs2228479 0.850 rs117285117 chr16:89910250 T/G cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg22875332 chr1:76189707 ACADM 0.64 6.52 0.37 3.52e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg26874164 chr19:58962979 ZNF324B 0.54 7.47 0.42 1.2e-12 Uric acid clearance; CESC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg26314531 chr2:26401878 FAM59B -0.83 -9.26 -0.49 7.29e-18 Gut microbiome composition (summer); CESC cis rs568617 0.768 rs12225345 chr11:65647105 A/G cg19792802 chr11:65647270 CTSW 0.39 5.2 0.3 4e-7 Crohn's disease; CESC cis rs1728785 0.786 rs1728770 chr16:68564124 G/C cg02972257 chr16:68554789 NA -0.62 -6.95 -0.39 2.88e-11 Ulcerative colitis; CESC cis rs977987 0.966 rs6564261 chr16:75492242 C/T cg03315344 chr16:75512273 CHST6 0.53 7.82 0.43 1.22e-13 Dupuytren's disease; CESC cis rs10504073 0.525 rs10081464 chr8:50058707 A/G cg00325661 chr8:49890786 NA 0.41 5.83 0.34 1.63e-8 Blood metabolite ratios; CESC cis rs561341 0.941 rs2428336 chr17:30290577 T/C cg00745463 chr17:30367425 LRRC37B -0.69 -6.8 -0.39 6.97e-11 Hip circumference adjusted for BMI; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22692790 chr10:70748415 KIAA1279 0.53 7.46 0.42 1.26e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs798554 0.548 rs1639064 chr7:2896544 G/A cg19717773 chr7:2847554 GNA12 -0.49 -7.43 -0.42 1.54e-12 Height; CESC cis rs926938 0.527 rs360684 chr1:115499001 A/G cg12756093 chr1:115239321 AMPD1 0.44 6.06 0.35 4.58e-9 Autism; CESC cis rs8014204 0.967 rs1319171 chr14:75334096 G/T cg26191576 chr14:75389716 RPS6KL1 0.37 5.28 0.31 2.73e-7 Caffeine consumption; CESC cis rs2228479 0.717 rs11644967 chr16:89806614 T/A cg04013166 chr16:89971882 TCF25 0.78 8.27 0.45 6.71e-15 Skin colour saturation; CESC trans rs6951245 0.744 rs10265758 chr7:1172518 C/T cg13565492 chr6:43139072 SRF -0.61 -6.4 -0.37 6.96e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3768617 0.510 rs10458355 chr1:183063993 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 14.24 0.66 1.45e-34 Fuchs's corneal dystrophy; CESC cis rs727505 1.000 rs7790856 chr7:124459852 C/T cg23710748 chr7:124431027 NA -0.38 -6.05 -0.35 4.82e-9 Lewy body disease; CESC cis rs11785693 0.862 rs73189843 chr8:5000915 C/T cg26367366 chr8:4980734 NA 0.8 7.66 0.43 3.47e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg01988459 chr11:68622903 NA -0.46 -6.53 -0.37 3.28e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9487051 0.799 rs830553 chr6:109550017 T/G cg01475377 chr6:109611718 NA -0.4 -5.89 -0.34 1.18e-8 Reticulocyte fraction of red cells; CESC cis rs6693567 0.545 rs1694380 chr1:150292341 A/G cg09579323 chr1:150459698 TARS2 0.47 6.13 0.35 3.18e-9 Migraine; CESC cis rs12618769 0.656 rs3769735 chr2:99092302 C/T cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.68e-7 Bipolar disorder; CESC cis rs2933343 0.649 rs1683786 chr3:128626952 T/C cg24203234 chr3:128598194 ACAD9 0.43 5.82 0.34 1.74e-8 IgG glycosylation; CESC cis rs7274811 0.744 rs209677 chr20:32140287 C/T cg21523528 chr20:32077966 CBFA2T2 -0.42 -5.11 -0.3 6.2e-7 Height; CESC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg22903471 chr2:27725779 GCKR -0.59 -8.48 -0.46 1.65e-15 Total body bone mineral density; CESC cis rs7264396 0.563 rs56941405 chr20:34313426 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.78 -0.55 1.03e-22 Total cholesterol levels; CESC trans rs1497546 0.867 rs73853752 chr3:97940423 T/C cg12626411 chr1:186265765 PRG4;MIR548F1 0.85 6.36 0.36 8.62e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.37 0.5 3.2e-18 Menopause (age at onset); CESC cis rs10789491 1.000 rs618505 chr1:47144532 T/C cg15501359 chr1:47185051 KIAA0494 0.8 8.63 0.47 5.59e-16 Response to hepatitis C treatment; CESC cis rs8072100 0.748 rs9908016 chr17:45551361 G/A cg08085267 chr17:45401833 C17orf57 -0.58 -7.7 -0.43 2.77e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs12310956 0.532 rs10844707 chr12:33936089 T/C cg26384229 chr12:38710491 ALG10B 0.57 7.96 0.44 5.09e-14 Morning vs. evening chronotype; CESC cis rs6088590 1.000 rs6087625 chr20:33342477 A/G cg06115741 chr20:33292138 TP53INP2 -0.58 -7.16 -0.4 7.99e-12 Coronary artery disease; CESC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg11764359 chr7:65958608 NA -0.69 -9.06 -0.49 2.98e-17 Aortic root size; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg22696252 chr3:97540975 NA -0.4 -6.04 -0.35 5.1e-9 Breast cancer; CESC cis rs9815354 0.812 rs113300894 chr3:41984243 G/C cg03022575 chr3:42003672 ULK4 0.67 5.92 0.34 9.77e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs2304069 0.913 rs7734382 chr5:149383241 A/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.88 11.21 0.57 4.03e-24 HIV-1 control; CESC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg26343298 chr8:95960752 TP53INP1 0.37 6.14 0.35 3.07e-9 Type 2 diabetes; CESC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg14893161 chr1:205819251 PM20D1 0.88 14.01 0.65 9.2e-34 Menarche (age at onset); CESC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg18230493 chr5:56204884 C5orf35 0.61 8.0 0.44 3.99e-14 Initial pursuit acceleration; CESC cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs77106637 0.860 rs7129793 chr11:72455885 C/T cg04827223 chr11:72435913 ARAP1 -0.58 -5.53 -0.32 7.67e-8 Type 2 diabetes; CESC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg00684032 chr4:1343700 KIAA1530 0.42 6.58 0.37 2.55e-10 Longevity; CESC cis rs2302190 0.882 rs11650105 chr17:56588072 C/T cg25885038 chr17:56607967 SEPT4 -0.42 -5.7 -0.33 3.22e-8 Vitamin D levels; CESC cis rs1348850 0.914 rs4893950 chr2:178304885 T/C cg22681709 chr2:178499509 PDE11A -0.43 -6.07 -0.35 4.34e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs13098911 0.540 rs36023124 chr3:46039060 G/C cg10236987 chr1:228114221 WNT9A 0.66 6.54 0.37 3.11e-10 Celiac disease; CESC cis rs7714584 1.000 rs6579804 chr5:150255931 T/C cg22134413 chr5:150180641 NA 0.51 5.92 0.34 9.88e-9 Crohn's disease; CESC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg07677032 chr17:61819896 STRADA 0.45 5.91 0.34 1.03e-8 Prudent dietary pattern; CESC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg15445000 chr17:37608096 MED1 0.39 6.38 0.36 7.82e-10 Glomerular filtration rate (creatinine); CESC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg11764359 chr7:65958608 NA 0.81 11.74 0.58 6.73e-26 Aortic root size; CESC cis rs1348850 0.914 rs11893448 chr2:178280013 T/C cg23306229 chr2:178417860 TTC30B 0.65 8.41 0.46 2.59e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7824557 0.603 rs7016671 chr8:11182455 A/G cg21775007 chr8:11205619 TDH 0.54 8.4 0.46 2.77e-15 Retinal vascular caliber; CESC cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg18225595 chr11:63971243 STIP1 0.74 10.23 0.53 6.64e-21 Platelet count; CESC cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.48 6.08 0.35 4.15e-9 Tonsillectomy; CESC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg13777783 chr17:79615861 NA -0.37 -6.15 -0.35 2.83e-9 Eye color traits; CESC cis rs3733585 0.699 rs7437120 chr4:9967683 T/A cg00071950 chr4:10020882 SLC2A9 -0.7 -11.47 -0.58 5.33e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs863345 0.933 rs10908659 chr1:158465858 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.01 -0.35 6.09e-9 Pneumococcal bacteremia; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg07797367 chr6:84136471 ME1 0.43 6.39 0.37 7.38e-10 Cleft plate (environmental tobacco smoke interaction); CESC trans rs4332037 0.901 rs7791899 chr7:1935988 T/C cg11693508 chr17:37793320 STARD3 0.65 6.11 0.35 3.55e-9 Bipolar disorder; CESC cis rs11997175 0.503 rs7013967 chr8:33826107 T/G ch.8.33884649F chr8:33765107 NA 0.6 7.48 0.42 1.1e-12 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01471259 chr16:2645846 PDPK1 -0.61 -6.86 -0.39 4.88e-11 Gut microbiome composition (summer); CESC trans rs62103177 0.673 rs62096717 chr18:77616819 C/T cg05926928 chr17:57297772 GDPD1 0.78 8.19 0.45 1.08e-14 Opioid sensitivity; CESC cis rs1008375 1.000 rs2058339 chr4:17678456 C/T cg16339924 chr4:17578868 LAP3 0.51 6.6 0.38 2.21e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10927875 0.597 rs61782184 chr1:16150976 G/A cg18973939 chr1:16164122 FLJ37453 0.38 5.66 0.33 4.01e-8 Dilated cardiomyopathy; CESC cis rs2180341 0.960 rs7751865 chr6:127683040 G/A cg27446573 chr6:127587934 RNF146 1.06 15.88 0.7 2.39e-40 Breast cancer; CESC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg00166722 chr3:10149974 C3orf24 0.51 6.38 0.37 7.76e-10 Alzheimer's disease; CESC cis rs703842 0.963 rs2069506 chr12:58142854 C/A cg18357645 chr12:58087776 OS9 -0.43 -6.13 -0.35 3.19e-9 Multiple sclerosis; CESC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg19346786 chr7:2764209 NA -0.51 -7.4 -0.41 1.77e-12 Height; CESC cis rs9314614 0.933 rs2741098 chr8:6690276 C/T cg27319216 chr8:6693540 XKR5 0.37 5.39 0.31 1.54e-7 IgA nephropathy;White blood cell count (basophil); CESC cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg24846343 chr22:24311635 DDTL -0.45 -6.36 -0.36 8.61e-10 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs1670533 0.932 rs13140341 chr4:1054235 T/C cg27284194 chr4:1044797 NA 0.46 5.82 0.34 1.68e-8 Recombination rate (females); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19345149 chr11:116658875 ZNF259 0.72 8.57 0.47 8.67e-16 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs17407555 0.909 rs56133633 chr4:10291351 G/T cg11266682 chr4:10021025 SLC2A9 -0.48 -5.69 -0.33 3.42e-8 Schizophrenia (age at onset); CESC cis rs8022179 0.566 rs959083 chr14:103822687 A/G cg12935359 chr14:103987150 CKB -0.47 -5.77 -0.33 2.17e-8 Monocyte count; CESC cis rs75064307 0.834 rs10511271 chr3:108114572 A/G cg03329597 chr3:108125523 MYH15 -0.5 -5.66 -0.33 3.86e-8 Intelligence (multi-trait analysis); CESC cis rs71277158 0.688 rs73030653 chr3:169841926 G/A cg04067573 chr3:169899625 PHC3 0.67 6.88 0.39 4.23e-11 Prostate cancer; CESC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg21951975 chr1:209979733 IRF6 0.6 8.61 0.47 6.58e-16 Cleft lip with or without cleft palate; CESC cis rs7937682 0.889 rs11213969 chr11:111528441 A/G cg22437258 chr11:111473054 SIK2 0.69 9.25 0.49 7.9e-18 Primary sclerosing cholangitis; CESC cis rs1153858 1.000 rs56669689 chr15:45637729 A/C cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs5750830 0.645 rs4821890 chr22:39777523 G/A cg24399712 chr22:39784796 NA -0.72 -10.59 -0.55 4.38e-22 Intelligence (multi-trait analysis); CESC cis rs7223966 1.000 rs1877316 chr17:61766880 C/A cg11494091 chr17:61959527 GH2 0.37 5.04 0.3 8.73e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg07167872 chr1:205819463 PM20D1 0.72 11.5 0.58 4.39e-25 Menarche (age at onset); CESC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg16145915 chr7:1198662 ZFAND2A -0.48 -7.02 -0.4 1.8e-11 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03846689 chr6:111135840 CDK19 0.6 7.35 0.41 2.51e-12 Gut microbiome composition (summer); CESC cis rs7071206 0.853 rs114936111 chr10:79430143 G/A cg07817648 chr10:79422355 NA -0.78 -10.21 -0.53 7.37e-21 Bone mineral density; CESC cis rs2404602 0.716 rs1125932 chr15:76820540 C/T cg22467129 chr15:76604101 ETFA -0.35 -5.31 -0.31 2.33e-7 Blood metabolite levels; CESC trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.35 -0.46 3.8e-15 Intelligence (multi-trait analysis); CESC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.53 -8.06 -0.44 2.64e-14 Total body bone mineral density; CESC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg03452623 chr4:187889614 NA 0.88 15.11 0.68 1.26e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs8017423 0.967 rs11627429 chr14:90689232 G/A cg14092571 chr14:90743983 NA 0.52 7.58 0.42 6e-13 Mortality in heart failure; CESC cis rs5167 0.506 rs7257916 chr19:45482884 T/C cg20090143 chr19:45452003 APOC2 -0.34 -5.37 -0.31 1.72e-7 Blood protein levels; CESC cis rs9457247 1.000 rs385863 chr6:167386615 C/G cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg06766960 chr11:133703094 NA -0.39 -5.45 -0.32 1.14e-7 Childhood ear infection; CESC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg18337363 chr3:52569053 NT5DC2 0.29 5.14 0.3 5.27e-7 Bipolar disorder; CESC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.22e-8 Lung cancer; CESC cis rs8005677 1.000 rs2295683 chr14:23388382 A/C cg01529538 chr14:23388837 RBM23 0.51 6.87 0.39 4.64e-11 Cognitive ability (multi-trait analysis); CESC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg24829409 chr8:58192753 C8orf71 -0.49 -5.99 -0.35 6.9e-9 Developmental language disorder (linguistic errors); CESC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg23590916 chr17:43697445 MGC57346 -0.6 -6.3 -0.36 1.23e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11779988 0.598 rs6980962 chr8:17909992 G/A cg18067069 chr8:17937731 ASAH1 -0.39 -5.17 -0.3 4.57e-7 Breast cancer; CESC cis rs4523957 0.579 rs2307143 chr17:2089754 G/A cg16513277 chr17:2031491 SMG6 -0.63 -8.81 -0.48 1.7e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg02951883 chr7:2050386 MAD1L1 -0.54 -7.09 -0.4 1.24e-11 Bipolar disorder and schizophrenia; CESC cis rs11122272 0.735 rs2009873 chr1:231499236 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.27 0.36 1.47e-9 Hemoglobin concentration; CESC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs734999 0.588 rs4648653 chr1:2535895 C/T cg18854424 chr1:2615690 NA 0.27 5.26 0.31 3e-7 Ulcerative colitis; CESC cis rs2637266 0.678 rs11498047 chr10:78464839 G/A cg18941641 chr10:78392320 NA 0.38 6.86 0.39 4.82e-11 Pulmonary function; CESC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg13628971 chr7:2884303 GNA12 0.65 9.09 0.49 2.36e-17 Height; CESC cis rs7178572 1.000 rs952472 chr15:77776562 A/C cg22256960 chr15:77711686 NA -0.6 -8.09 -0.44 2.19e-14 Type 2 diabetes; CESC cis rs6691722 0.503 rs1064842 chr1:24706269 A/G cg02336364 chr1:24764700 NIPAL3 0.33 6.8 0.39 6.86e-11 Response to interferon beta in multiple sclerosis; CESC cis rs9549367 0.789 rs3794422 chr13:113893729 G/A cg00898013 chr13:113819073 PROZ -0.53 -7.36 -0.41 2.37e-12 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05290708 chr7:140372864 ADCK2 0.57 6.02 0.35 5.71e-9 Gut microbiome composition (summer); CESC cis rs7551345 0.563 rs4949365 chr1:31690861 C/T cg25010788 chr1:31654453 NKAIN1 -0.36 -5.25 -0.31 3.16e-7 Schizophrenia; CESC cis rs9811920 0.516 rs793485 chr3:99492383 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.34 -5.47 -0.32 1.03e-7 Axial length; CESC cis rs11122272 0.735 rs2250719 chr1:231486208 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.21 0.36 2.03e-9 Hemoglobin concentration; CESC cis rs6088580 0.619 rs1205335 chr20:32927507 C/T cg08999081 chr20:33150536 PIGU -0.64 -11.02 -0.56 1.75e-23 Glomerular filtration rate (creatinine); CESC trans rs4950322 0.542 rs28381210 chr1:146673507 C/A cg04954894 chr8:38089920 DDHD2 -0.62 -6.34 -0.36 9.73e-10 Protein quantitative trait loci; CESC cis rs7927592 0.731 rs10896350 chr11:68386373 A/C cg16797656 chr11:68205561 LRP5 0.46 6.77 0.38 8.45e-11 Total body bone mineral density; CESC cis rs769267 0.930 rs747050 chr19:19584987 C/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.93 0.34 9.3e-9 Tonsillectomy; CESC cis rs4727027 0.840 rs12670633 chr7:148796707 G/A cg23158103 chr7:148848205 ZNF398 -0.42 -6.84 -0.39 5.49e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7786877 0.626 rs11767547 chr7:100221635 C/T cg27028030 chr7:100209634 MOSPD3 0.59 5.65 0.33 4.13e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9291683 0.609 rs12507050 chr4:10007305 G/T cg11266682 chr4:10021025 SLC2A9 0.68 14.2 0.66 2.03e-34 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09924173 chr13:32526671 EEF1DP3 -0.58 -7.21 -0.4 5.68e-12 Gut microbiome composition (summer); CESC cis rs1003719 0.788 rs4816560 chr21:38487561 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 8.38 0.46 3.07e-15 Eye color traits; CESC trans rs9858542 1.000 rs6770670 chr3:49686682 T/C cg21659725 chr3:3221576 CRBN -0.53 -6.49 -0.37 4.09e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs710216 0.957 rs12041787 chr1:43432275 G/C cg03128534 chr1:43423976 SLC2A1 0.55 6.36 0.36 8.7e-10 Red cell distribution width; CESC cis rs66561647 0.719 rs3739380 chr8:128944507 G/T cg05480350 chr8:128972681 MIR1205;PVT1 0.46 6.01 0.35 6.15e-9 Hemoglobin concentration; CESC cis rs17253792 0.822 rs75016910 chr14:56050466 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.66 0.33 3.84e-8 Putamen volume; CESC cis rs7429990 0.932 rs2166772 chr3:48047874 C/T cg11946769 chr3:48343235 NME6 -0.44 -5.28 -0.31 2.75e-7 Educational attainment (years of education); CESC cis rs5758511 0.689 rs62240864 chr22:42563889 C/T cg00645731 chr22:42541494 CYP2D7P1 0.58 7.09 0.4 1.25e-11 Birth weight; CESC cis rs858239 0.600 rs2072368 chr7:23146112 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.51 0.42 9.26e-13 Cerebrospinal fluid biomarker levels; CESC cis rs1538970 0.851 rs61788285 chr1:45919234 A/C cg24296786 chr1:45957014 TESK2 -0.46 -5.15 -0.3 5.16e-7 Platelet count; CESC trans rs1386330 1.000 rs1386330 chr11:87819427 C/T cg08079596 chr2:85999628 ATOH8 -0.54 -6.19 -0.36 2.28e-9 Multiple sclerosis (age of onset); CESC cis rs3820928 0.874 rs10174073 chr2:227794944 A/G cg11843606 chr2:227700838 RHBDD1 -0.5 -6.72 -0.38 1.09e-10 Pulmonary function; CESC cis rs4595586 0.545 rs6580893 chr12:39371885 G/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs9837602 1.000 rs4279135 chr3:99733096 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.51 0.42 9.05e-13 Breast cancer; CESC cis rs7089973 0.604 rs10885620 chr10:116630048 A/T cg03647239 chr10:116582469 FAM160B1 0.47 6.13 0.35 3.11e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7100689 0.646 rs7919380 chr10:82133380 C/T cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs13385 0.769 rs4913075 chr5:139613571 A/G cg26211634 chr5:139558579 C5orf32 0.49 5.41 0.32 1.41e-7 Atrial fibrillation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01799560 chr17:80846075 TBCD -0.54 -6.1 -0.35 3.68e-9 Gut microbiome composition (summer); CESC cis rs2820315 0.505 rs10800792 chr1:201811144 G/A cg06775570 chr1:201857621 SHISA4 0.31 5.22 0.31 3.57e-7 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; CESC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg23982607 chr1:1823379 GNB1 -0.78 -12.66 -0.61 4.62e-29 Body mass index; CESC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg03188948 chr7:1209495 NA 0.56 6.54 0.37 3.19e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg07677032 chr17:61819896 STRADA 0.49 6.7 0.38 1.22e-10 Prudent dietary pattern; CESC trans rs1814175 0.619 rs847644 chr11:49918418 G/A cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg15017067 chr4:17643749 FAM184B -0.39 -5.68 -0.33 3.58e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10887741 0.690 rs7908056 chr10:89444650 G/A cg13926569 chr10:89418898 PAPSS2 0.38 5.52 0.32 7.96e-8 Exercise (leisure time); CESC cis rs7662987 1.000 rs28730591 chr4:100003747 G/A cg13256891 chr4:100009986 ADH5 -0.72 -5.39 -0.31 1.52e-7 Smoking initiation; CESC cis rs7592578 0.766 rs62182865 chr2:191434180 T/C cg27211696 chr2:191398769 TMEM194B -0.64 -5.54 -0.32 7.42e-8 Diastolic blood pressure; CESC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.54 -0.32 7.11e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs9833726 0.589 rs9990223 chr3:86134368 A/G cg10416071 chr15:75628863 COMMD4 0.62 6.19 0.36 2.28e-9 Breast cancer; CESC cis rs12545109 0.800 rs1837617 chr8:57417592 C/T cg09654669 chr8:57350985 NA -0.53 -6.42 -0.37 6.27e-10 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01744729 chr13:113474194 ATP11A 0.51 7.1 0.4 1.17e-11 Fibrinogen levels; CESC cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg05340658 chr4:99064831 C4orf37 0.81 12.49 0.61 1.85e-28 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs6878087 chr5:223117 C/T cg22857025 chr5:266934 NA 1.19 17.44 0.73 6.79e-46 Breast cancer; CESC trans rs9364687 0.966 rs13202733 chr6:163802590 G/A cg08378220 chr11:102678779 NA -0.39 -6.18 -0.35 2.39e-9 Body mass index; CESC trans rs13098911 0.540 rs34863575 chr3:46094063 A/G cg10236987 chr1:228114221 WNT9A 0.63 6.2 0.36 2.12e-9 Celiac disease; CESC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg22903471 chr2:27725779 GCKR -0.56 -8.05 -0.44 2.86e-14 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12050434 chr12:43030949 NA -0.63 -7.47 -0.42 1.13e-12 Gut microbiome composition (summer); CESC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg07747251 chr5:1868357 NA 0.32 5.4 0.32 1.46e-7 Cardiovascular disease risk factors; CESC cis rs2274273 0.967 rs67756714 chr14:55589823 G/A cg04306507 chr14:55594613 LGALS3 0.31 5.69 0.33 3.29e-8 Protein biomarker; CESC trans rs9771228 1.000 rs215599 chr7:32330129 C/T cg22296808 chr11:2560641 KCNQ1 -0.39 -6.01 -0.35 6.13e-9 Cognitive ability;Verbal-numerical reasoning; CESC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg18180107 chr4:99064573 C4orf37 -0.46 -5.61 -0.33 5.19e-8 Colonoscopy-negative controls vs population controls; CESC cis rs8141529 0.778 rs7287806 chr22:29213011 G/A cg15103426 chr22:29168792 CCDC117 0.68 9.74 0.51 2.29e-19 Lymphocyte counts; CESC cis rs7267979 0.966 rs2261698 chr20:25259910 A/G cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs921968 0.565 rs692049 chr2:219622778 G/A cg02176678 chr2:219576539 TTLL4 -0.39 -6.81 -0.39 6.45e-11 Mean corpuscular hemoglobin concentration; CESC cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg18876405 chr7:65276391 NA 0.49 5.38 0.31 1.63e-7 Aortic root size; CESC cis rs753778 0.629 rs2278447 chr8:142206905 G/C cg18755752 chr8:142205143 DENND3 -0.67 -9.8 -0.52 1.51e-19 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs17253792 0.822 rs75351812 chr14:56082192 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg12373951 chr3:133503437 NA 0.43 6.3 0.36 1.24e-9 Iron status biomarkers; CESC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg00409905 chr10:38381863 ZNF37A -0.45 -6.01 -0.35 6.11e-9 Extrinsic epigenetic age acceleration; CESC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg24503407 chr1:205819492 PM20D1 0.8 12.91 0.62 6.65e-30 Menarche (age at onset); CESC cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg03676636 chr4:99064102 C4orf37 0.34 5.15 0.3 5.17e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12711979 0.765 rs13030772 chr2:3821280 T/C cg17052675 chr2:3827356 NA -0.41 -6.47 -0.37 4.64e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs8114671 0.527 rs6060068 chr20:33415820 T/A cg08999081 chr20:33150536 PIGU 0.39 5.52 0.32 7.98e-8 Height; CESC cis rs611744 0.647 rs1457211 chr8:109261318 C/T cg21045802 chr8:109455806 TTC35 -0.49 -6.04 -0.35 5.2e-9 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19681528 chr10:69644405 SIRT1 0.55 6.42 0.37 6.32e-10 Gut microbiome composition (summer); CESC cis rs2625529 0.652 rs2929508 chr15:72246964 A/T cg16672083 chr15:72433130 SENP8 0.37 5.54 0.32 7.27e-8 Red blood cell count; CESC cis rs2439831 0.867 rs76542740 chr15:43891512 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.83 8.72 0.47 3.08e-16 Lung cancer in ever smokers; CESC cis rs3806843 1.000 rs12055222 chr5:140165568 T/C cg26395211 chr5:140044315 WDR55 -0.43 -5.47 -0.32 1.05e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7246657 1.000 rs7246657 chr19:37747108 C/T cg23950597 chr19:37808831 NA 0.54 6.02 0.35 5.82e-9 Coronary artery calcification; CESC trans rs9874872 0.744 rs12488837 chr3:31517150 T/C cg22073152 chr1:198633497 PTPRC -0.59 -6.02 -0.35 5.72e-9 Urinary uric acid to urinary creatinine ratio; CESC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg16262614 chr3:133464971 TF 0.28 5.06 0.3 7.95e-7 Iron status biomarkers; CESC cis rs9926296 0.632 rs9935559 chr16:89800529 C/T cg27121462 chr16:89883253 FANCA -0.63 -7.86 -0.43 9.46e-14 Vitiligo; CESC cis rs17039065 0.920 rs73838440 chr4:109457882 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.66 6.18 0.35 2.47e-9 Gut microbiome composition (summer); CESC cis rs1178968 0.901 rs1178970 chr7:72750345 G/A cg25889504 chr7:72793014 NA 0.44 5.09 0.3 6.71e-7 Triglyceride levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23199886 chr2:107199044 NA -0.58 -7.0 -0.4 2.12e-11 Gut microbiome composition (summer); CESC cis rs2985684 0.789 rs7161649 chr14:50064028 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.46 -5.58 -0.32 6.08e-8 Carotid intima media thickness; CESC cis rs11764590 0.813 rs11768212 chr7:1992582 A/C cg23422044 chr7:1970798 MAD1L1 -0.5 -5.36 -0.31 1.77e-7 Neuroticism; CESC cis rs9790314 0.669 rs7630768 chr3:160864879 T/A cg03342759 chr3:160939853 NMD3 -0.4 -5.49 -0.32 9.28e-8 Morning vs. evening chronotype; CESC cis rs8020095 0.517 rs10047902 chr14:67349147 G/A cg19548862 chr14:67692701 FAM71D -0.47 -5.72 -0.33 2.94e-8 Depression (quantitative trait); CESC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 12.92 0.62 6.01e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs123509 0.731 rs73087348 chr3:42811571 C/T cg12982090 chr3:42733453 KBTBD5 -0.64 -7.16 -0.4 7.89e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6088590 0.687 rs8115656 chr20:33282780 G/C cg06115741 chr20:33292138 TP53INP2 0.52 6.45 0.37 5.4e-10 Coronary artery disease; CESC trans rs9949291 0.565 rs58553001 chr18:61362456 C/T cg18704691 chr1:221052468 HLX -0.39 -6.15 -0.35 2.89e-9 Eosinophil percentage of white cells; CESC cis rs6701037 0.782 rs12760073 chr1:175139295 G/T cg00321850 chr1:175162397 KIAA0040 -0.42 -6.06 -0.35 4.53e-9 Alcohol dependence; CESC cis rs644799 0.526 rs506180 chr11:95623109 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.5 6.48 0.37 4.45e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs1814175 0.817 rs1851860 chr11:49861310 A/C cg15704280 chr7:45808275 SEPT13 -1.0 -18.83 -0.76 8.9e-51 Height; CESC cis rs644799 0.542 rs10831416 chr11:95467220 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.66 9.39 0.5 2.87e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7568458 0.660 rs55692129 chr2:85792404 A/T cg02493740 chr2:85810744 VAMP5 -0.58 -8.14 -0.45 1.56e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20086523 chr13:52378287 DHRS12 0.58 6.56 0.37 2.73e-10 Gut microbiome composition (summer); CESC cis rs35146811 0.844 rs4424195 chr7:99642745 A/G cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.45 5.7 0.33 3.24e-8 Coronary artery disease; CESC cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg21918786 chr6:109611834 NA -0.41 -6.13 -0.35 3.24e-9 Reticulocyte fraction of red cells; CESC cis rs11098499 0.954 rs34858317 chr4:120387110 A/C cg09307838 chr4:120376055 NA 0.95 13.96 0.65 1.42e-33 Corneal astigmatism; CESC cis rs8092503 1.000 rs12960257 chr18:52481438 T/G cg12377874 chr18:52495404 RAB27B 0.38 6.2 0.36 2.13e-9 Childhood body mass index; CESC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg26314531 chr2:26401878 FAM59B 0.73 7.58 0.42 5.85e-13 Gut microbiome composition (summer); CESC cis rs752010 0.630 rs12134174 chr1:42105942 C/T cg06885757 chr1:42089581 HIVEP3 0.53 8.35 0.46 3.83e-15 Lupus nephritis in systemic lupus erythematosus; CESC trans rs4513299 1.000 rs7581142 chr2:115070817 C/G cg26275355 chr4:12252318 NA -0.35 -6.0 -0.35 6.45e-9 Inflammatory biomarkers; CESC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg18758796 chr5:131593413 PDLIM4 0.44 6.17 0.35 2.61e-9 Breast cancer; CESC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg13902645 chr11:5959945 NA -0.61 -7.63 -0.42 4.34e-13 DNA methylation (variation); CESC cis rs6460942 1.000 rs2033871 chr7:12405098 C/A cg17427002 chr7:12443146 VWDE -0.52 -5.27 -0.31 2.82e-7 Coronary artery disease; CESC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg17372223 chr3:52568218 NT5DC2 0.43 6.49 0.37 4.29e-10 Bipolar disorder; CESC cis rs4727027 0.933 rs917123 chr7:148848358 G/A cg23158103 chr7:148848205 ZNF398 -0.43 -7.11 -0.4 1.06e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg10295955 chr4:187884368 NA -1.05 -18.46 -0.75 1.69e-49 Lobe attachment (rater-scored or self-reported); CESC cis rs11645898 0.748 rs3852785 chr16:72198642 G/A cg14768367 chr16:72042858 DHODH -0.75 -6.06 -0.35 4.74e-9 Blood protein levels; CESC cis rs7615952 0.611 rs7632305 chr3:125634767 C/T cg05084668 chr3:125655381 ALG1L -0.77 -7.77 -0.43 1.75e-13 Blood pressure (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12559670 chr7:1610220 PSMG3;KIAA1908 0.56 6.36 0.36 8.92e-10 Gut microbiome composition (summer); CESC cis rs11098499 0.863 rs3775858 chr4:120486028 A/G cg24375607 chr4:120327624 NA 0.44 5.38 0.31 1.6e-7 Corneal astigmatism; CESC cis rs2228479 0.850 rs11640336 chr16:89941153 T/C cg06558623 chr16:89946397 TCF25 0.95 7.72 0.43 2.36e-13 Skin colour saturation; CESC cis rs8002861 0.875 rs11616803 chr13:44457109 A/G cg14210620 chr13:44453864 C13orf31;CCDC122 -0.44 -5.58 -0.32 5.88e-8 Leprosy; CESC cis rs6430585 0.583 rs111837148 chr2:136612036 G/A cg07169764 chr2:136633963 MCM6 1.29 19.97 0.78 9.47e-55 Corneal structure; CESC cis rs7006290 0.518 rs13282526 chr8:41641151 T/C cg08923054 chr8:41654455 ANK1 0.45 5.27 0.31 2.79e-7 Pulmonary function decline; CESC cis rs7937682 0.883 rs1789358 chr11:111474116 G/A cg22437258 chr11:111473054 SIK2 0.74 9.86 0.52 9.59e-20 Primary sclerosing cholangitis; CESC cis rs9863 0.828 rs12303933 chr12:124482256 T/C cg17562584 chr12:124393655 DNAH10 0.3 5.22 0.31 3.67e-7 White blood cell count; CESC cis rs4819852 1.000 rs1034565 chr22:19984211 A/G cg07821417 chr22:19972146 ARVCF -0.26 -5.05 -0.3 8.27e-7 Pulse pressure; CESC cis rs8114671 0.562 rs6120739 chr20:33405227 A/G cg07148914 chr20:33460835 GGT7 0.42 5.38 0.31 1.64e-7 Height; CESC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg15145296 chr3:125709740 NA 0.49 5.35 0.31 1.9e-7 Blood pressure (smoking interaction); CESC cis rs7208859 0.725 rs9910051 chr17:29161202 A/T cg19761014 chr17:28927070 LRRC37B2 0.57 5.64 0.33 4.37e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.53 7.89 0.44 7.99e-14 Electroencephalogram traits; CESC cis rs4268898 0.662 rs35624938 chr2:24576651 T/C cg06627628 chr2:24431161 ITSN2 -1.04 -11.91 -0.59 1.81e-26 Asthma; CESC cis rs11083475 0.599 rs7250443 chr19:39267345 T/C cg26703956 chr19:39260304 NA -0.29 -5.48 -0.32 9.78e-8 Heart rate; CESC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg17372223 chr3:52568218 NT5DC2 0.4 5.99 0.35 6.76e-9 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07899956 chr17:74261249 FAM100B 0.58 7.14 0.4 9.04e-12 Gut microbiome composition (summer); CESC cis rs2760061 0.598 rs673726 chr1:228120173 T/C cg02753203 chr1:228287806 NA -0.51 -7.43 -0.42 1.5e-12 Diastolic blood pressure; CESC cis rs8027181 0.839 rs8024986 chr15:73024868 A/G cg25632853 chr15:73088954 NA -0.29 -5.09 -0.3 6.84e-7 Triglyceride levels; CESC trans rs123509 0.913 rs339686 chr3:42769688 T/C cg22035501 chr5:112073398 APC 0.56 5.99 0.35 6.71e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg26597838 chr10:835615 NA 0.86 9.51 0.5 1.21e-18 Eosinophil percentage of granulocytes; CESC cis rs9309473 1.000 rs13398956 chr2:73720258 C/A cg20560298 chr2:73613845 ALMS1 -0.55 -7.15 -0.4 8.23e-12 Metabolite levels; CESC cis rs561341 1.000 rs554078 chr17:30330109 A/C cg00745463 chr17:30367425 LRRC37B -0.86 -7.79 -0.43 1.53e-13 Hip circumference adjusted for BMI; CESC cis rs2425143 1.000 rs1118233 chr20:34228349 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -7.43 -0.42 1.49e-12 Blood protein levels; CESC cis rs4568518 0.530 rs6461364 chr7:17992404 G/T cg03009463 chr7:17980271 SNX13 0.41 5.38 0.31 1.68e-7 Measles; CESC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg15445000 chr17:37608096 MED1 0.39 6.42 0.37 6.17e-10 Glomerular filtration rate (creatinine); CESC cis rs11608355 0.508 rs2075434 chr12:109797051 G/A cg19025524 chr12:109796872 NA -0.45 -5.54 -0.32 7.31e-8 Neuroticism; CESC trans rs17581137 0.591 rs2397804 chr15:96179023 C/T cg18848301 chr6:44590128 NA -0.37 -6.22 -0.36 1.95e-9 Coronary artery disease; CESC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg00933542 chr6:150070202 PCMT1 0.29 5.06 0.3 7.67e-7 Lung cancer; CESC trans rs34421088 0.560 rs2618434 chr8:11398865 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -6.0 -0.35 6.33e-9 Neuroticism; CESC cis rs6062302 0.522 rs3787112 chr20:62222411 G/A cg09650180 chr20:62225654 GMEB2 -0.79 -8.96 -0.48 6.01e-17 Glioblastoma; CESC cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg16339924 chr4:17578868 LAP3 0.66 8.41 0.46 2.52e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9916302 0.706 rs9646419 chr17:37597185 A/G cg07936489 chr17:37558343 FBXL20 -0.9 -9.82 -0.52 1.32e-19 Glomerular filtration rate (creatinine); CESC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg02018176 chr4:1364513 KIAA1530 -0.38 -5.07 -0.3 7.43e-7 Obesity-related traits; CESC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg24642844 chr7:1081250 C7orf50 -0.74 -8.81 -0.48 1.64e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.9 0.52 7.05e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg22455342 chr2:225449267 CUL3 0.72 9.87 0.52 9.27e-20 IgE levels in asthmatics (D.p. specific); CESC cis rs999943 0.846 rs9366826 chr6:33619184 C/G cg14003231 chr6:33640908 ITPR3 0.63 11.16 0.57 5.66e-24 Obesity (extreme); CESC cis rs116095464 0.614 rs78905930 chr5:246560 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.31 0.31 2.36e-7 Breast cancer; CESC cis rs7223966 0.960 rs7212379 chr17:61706122 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.69 0.38 1.28e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg22143856 chr6:28129313 ZNF389 -0.49 -6.41 -0.37 6.52e-10 Depression; CESC cis rs6500395 1.000 rs871902 chr16:48593779 A/G cg04672837 chr16:48644449 N4BP1 0.5 6.23 0.36 1.78e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg17949981 chr6:28129498 ZNF389 0.41 5.33 0.31 2.09e-7 Depression; CESC cis rs17376456 0.877 rs10078194 chr5:93364310 A/C cg25358565 chr5:93447407 FAM172A 1.1 10.88 0.56 4.74e-23 Diabetic retinopathy; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg00844078 chr2:26098817 ASXL2 0.41 6.58 0.37 2.45e-10 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19730813 chr7:128470217 FLNC -0.51 -6.03 -0.35 5.49e-9 Gut microbiome composition (summer); CESC cis rs9527 0.830 rs11191440 chr10:104641511 G/A cg04362960 chr10:104952993 NT5C2 0.45 5.28 0.31 2.69e-7 Arsenic metabolism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05910615 chr19:36248877 HSPB6;C19orf55 -0.48 -6.45 -0.37 5.23e-10 Ulcerative colitis; CESC cis rs1375194 0.606 rs2044644 chr2:33817559 A/G cg04131969 chr2:33951647 MYADML -0.51 -6.43 -0.37 5.8e-10 Response to antidepressants in depression; CESC cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.94 0.48 6.63e-17 Prostate cancer (SNP x SNP interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24044651 chr1:24105262 C1orf128 -0.48 -6.97 -0.39 2.48e-11 Gambling; CESC cis rs13102973 0.965 rs6535051 chr4:135874869 G/A cg14419869 chr4:135874104 NA -0.37 -5.78 -0.33 2.06e-8 Subjective well-being; CESC cis rs11264213 0.681 rs114705982 chr1:36232075 T/C cg27506609 chr1:36549197 TEKT2 0.65 5.34 0.31 1.97e-7 Schizophrenia; CESC cis rs2197308 0.631 rs4882308 chr12:38446252 G/C cg26384229 chr12:38710491 ALG10B -0.44 -5.95 -0.34 8.28e-9 Morning vs. evening chronotype; CESC cis rs2658782 1.000 rs2608216 chr11:93149172 G/A cg15737290 chr11:93063684 CCDC67 0.52 6.34 0.36 1e-9 Pulmonary function decline; CESC cis rs1580019 0.587 rs7804457 chr7:32557981 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 19.17 0.76 5.81e-52 Cognitive ability; CESC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg24578937 chr1:2090814 PRKCZ 0.37 6.61 0.38 2.16e-10 Height; CESC trans rs9929218 0.529 rs8060790 chr16:68729112 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.9 14.97 0.68 3.79e-37 Colorectal cancer; CESC cis rs977987 1.000 rs977985 chr16:75506947 C/G cg03315344 chr16:75512273 CHST6 0.57 8.21 0.45 9.79e-15 Dupuytren's disease; CESC cis rs7000551 0.751 rs2469768 chr8:22381362 G/A cg12081754 chr8:22256438 SLC39A14 0.42 5.64 0.33 4.24e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs10751667 0.666 rs10902235 chr11:938892 T/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.44 -0.32 1.23e-7 Alzheimer's disease (late onset); CESC cis rs2243480 0.522 rs1638736 chr7:66092308 A/T cg25985355 chr7:65971099 NA -0.51 -5.05 -0.3 8.22e-7 Diabetic kidney disease; CESC cis rs2304069 0.507 rs13167061 chr5:149388624 T/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.48 6.51 0.37 3.82e-10 HIV-1 control; CESC cis rs11112613 0.713 rs10507192 chr12:105948247 A/G cg03607813 chr12:105948248 NA 0.64 8.75 0.47 2.48e-16 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs939658 0.805 rs35602654 chr15:79417527 T/A cg17916960 chr15:79447300 NA -0.37 -6.1 -0.35 3.75e-9 Refractive error; CESC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg11644478 chr21:40555479 PSMG1 1.06 17.91 0.74 1.44e-47 Cognitive function; CESC cis rs6141600 0.760 rs2590986 chr20:34686496 C/A cg07747181 chr20:34652970 NA -0.38 -5.14 -0.3 5.25e-7 Height;Hip circumference; CESC cis rs72627123 0.867 rs8020310 chr14:74494437 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.74 5.72 0.33 2.85e-8 Morning vs. evening chronotype; CESC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs35110281 0.641 rs4818858 chr21:45083097 C/T cg01579765 chr21:45077557 HSF2BP 0.53 8.7 0.47 3.59e-16 Mean corpuscular volume; CESC cis rs9467711 0.606 rs34104395 chr6:26478252 C/T cg14345882 chr6:26364793 BTN3A2 0.64 5.21 0.3 3.75e-7 Autism spectrum disorder or schizophrenia; CESC cis rs6912958 0.781 rs2325064 chr6:88224467 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.11 -0.3 6.11e-7 Monocyte percentage of white cells; CESC cis rs4268898 0.662 rs2288074 chr2:24413595 C/T cg06627628 chr2:24431161 ITSN2 -1.01 -10.41 -0.54 1.68e-21 Asthma; CESC cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg22823121 chr1:150693482 HORMAD1 0.48 7.1 0.4 1.17e-11 Tonsillectomy; CESC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg06074448 chr4:187884817 NA -0.37 -5.5 -0.32 9.14e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs888194 0.677 rs7956194 chr12:109877825 C/T cg19025524 chr12:109796872 NA -0.41 -6.24 -0.36 1.73e-9 Neuroticism; CESC cis rs6032067 0.777 rs62208382 chr20:43785549 C/T cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs3750965 0.839 rs921670 chr11:68871639 C/T cg01403660 chr11:68851641 TPCN2 0.48 6.43 0.37 5.95e-10 Hair color; CESC cis rs11098499 0.675 rs11098534 chr4:120556772 T/G cg24375607 chr4:120327624 NA 0.4 5.09 0.3 6.82e-7 Corneal astigmatism; CESC trans rs116095464 0.558 rs7715108 chr5:264661 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.38e-11 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05232067 chr8:26240888 BNIP3L -0.47 -6.89 -0.39 4.05e-11 Gambling; CESC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg09359103 chr1:154839909 KCNN3 0.38 6.29 0.36 1.31e-9 Prostate cancer; CESC cis rs61996546 0.622 rs17560758 chr15:26836402 C/T cg14859324 chr15:26874363 GABRB3 -0.38 -5.12 -0.3 6e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg01516881 chr6:292596 DUSP22 -0.53 -6.92 -0.39 3.32e-11 Menopause (age at onset); CESC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.22e-18 Prudent dietary pattern; CESC cis rs2797160 1.000 rs6934435 chr6:126017481 T/G cg05901451 chr6:126070800 HEY2 0.45 6.46 0.37 5e-10 Endometrial cancer; CESC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg06877462 chr1:205807181 PM20D1 0.35 5.09 0.3 6.88e-7 Menarche (age at onset); CESC cis rs1568889 1.000 rs6484346 chr11:28040767 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.91 0.56 3.96e-23 Bipolar disorder; CESC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg22143856 chr6:28129313 ZNF389 0.51 6.55 0.37 3e-10 Depression; CESC cis rs11690935 0.632 rs12991740 chr2:172885996 C/T cg13550731 chr2:172543902 DYNC1I2 0.47 6.47 0.37 4.61e-10 Schizophrenia; CESC cis rs7909791 0.809 rs12570462 chr10:105613329 A/G cg24587175 chr10:105670608 OBFC1 -0.39 -5.67 -0.33 3.78e-8 White matter hyperintensity burden; CESC cis rs8018808 0.967 rs4903579 chr14:77850940 T/A cg20045696 chr14:77926864 AHSA1 -0.43 -5.81 -0.34 1.82e-8 Myeloid white cell count; CESC cis rs7772486 0.754 rs9497419 chr6:146142609 T/C cg23711669 chr6:146136114 FBXO30 0.89 13.07 0.63 1.87e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs9467711 0.606 rs66823108 chr6:26377939 G/A cg14345882 chr6:26364793 BTN3A2 0.62 6.24 0.36 1.75e-9 Autism spectrum disorder or schizophrenia; CESC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg15664640 chr17:80829946 TBCD -0.65 -9.4 -0.5 2.75e-18 Breast cancer; CESC cis rs889312 0.500 rs252920 chr5:56148741 C/A cg14703610 chr5:56206110 C5orf35 0.49 6.36 0.36 8.89e-10 Breast cancer;Breast cancer (early onset); CESC cis rs9811920 0.638 rs796978 chr3:99564321 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.6 -9.93 -0.52 5.9e-20 Axial length; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06469955 chr17:78915146 RPTOR 0.49 7.29 0.41 3.64e-12 Fibrinogen levels; CESC trans rs10463316 0.894 rs7703283 chr5:150764904 C/T cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs868036 0.918 rs4238411 chr15:68079424 A/T cg08079166 chr15:68083412 MAP2K5 0.41 6.45 0.37 5.41e-10 Restless legs syndrome; CESC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg11644478 chr21:40555479 PSMG1 0.83 12.81 0.62 1.5e-29 Cognitive function; CESC cis rs7726839 0.578 rs10080150 chr5:593160 C/T cg09021430 chr5:549028 NA 0.69 14.23 0.66 1.59e-34 Obesity-related traits; CESC trans rs2727020 0.521 rs10839296 chr11:49537617 T/C cg03929089 chr4:120376271 NA 0.7 7.9 0.44 7.44e-14 Coronary artery disease; CESC cis rs6991838 0.584 rs6991731 chr8:66555467 A/G cg13398993 chr8:66546079 ARMC1 0.49 5.89 0.34 1.18e-8 Intelligence (multi-trait analysis); CESC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg27121462 chr16:89883253 FANCA 0.79 11.82 0.59 3.58e-26 Vitiligo; CESC cis rs7927771 0.524 rs11039415 chr11:47845814 A/G cg20307385 chr11:47447363 PSMC3 0.62 8.62 0.47 6.37e-16 Subjective well-being; CESC cis rs9790314 1.000 rs9870059 chr3:161017240 T/C cg04691961 chr3:161091175 C3orf57 -0.44 -5.73 -0.33 2.74e-8 Morning vs. evening chronotype; CESC cis rs1784581 0.855 rs1790002 chr6:162384397 G/T cg17173639 chr6:162384350 PARK2 -0.81 -13.3 -0.63 2.97e-31 Itch intensity from mosquito bite; CESC trans rs7944735 0.671 rs7106731 chr11:48003392 T/G cg03929089 chr4:120376271 NA 0.54 6.33 0.36 1.05e-9 Intraocular pressure; CESC cis rs7017914 0.967 rs2100908 chr8:71583310 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.09 -0.3 6.93e-7 Bone mineral density; CESC cis rs116979167 0.545 rs1706914 chr7:105196445 A/T cg19920283 chr7:105172520 RINT1 0.5 5.7 0.33 3.17e-8 Bipolar disorder (body mass index interaction); CESC cis rs6088580 0.567 rs6088520 chr20:33132364 A/G cg06115741 chr20:33292138 TP53INP2 -0.43 -5.36 -0.31 1.78e-7 Glomerular filtration rate (creatinine); CESC cis rs793571 0.505 rs16940589 chr15:58898684 C/T cg05156742 chr15:59063176 FAM63B 0.49 5.05 0.3 8.29e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20681219 chr4:185396108 IRF2 0.53 6.08 0.35 4.22e-9 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg08888203 chr3:10149979 C3orf24 0.5 6.33 0.36 1.04e-9 Alzheimer's disease; CESC cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.46 6.13 0.35 3.1e-9 Eosinophil percentage of white cells; CESC cis rs9916302 0.821 rs412430 chr17:37737094 C/G cg15445000 chr17:37608096 MED1 0.39 6.19 0.36 2.31e-9 Glomerular filtration rate (creatinine); CESC cis rs2980439 0.556 rs2921059 chr8:8317887 G/T cg15556689 chr8:8085844 FLJ10661 0.63 8.51 0.46 1.31e-15 Neuroticism; CESC cis rs2204008 0.688 rs12824232 chr12:38175901 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs5769765 1.000 rs4824106 chr22:50267822 T/C cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg22467129 chr15:76604101 ETFA -0.38 -5.68 -0.33 3.56e-8 Blood metabolite levels; CESC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg04166393 chr7:2884313 GNA12 0.58 7.19 0.4 6.45e-12 Height; CESC cis rs10045504 0.502 rs57589709 chr5:38733853 C/T cg15396434 chr5:38725168 NA -0.69 -6.6 -0.38 2.17e-10 Night sleep phenotypes; CESC cis rs71403859 0.730 rs71386933 chr16:71821800 A/T cg08717414 chr16:71523259 ZNF19 -0.71 -5.87 -0.34 1.26e-8 Post bronchodilator FEV1; CESC cis rs854765 0.647 rs62073573 chr17:17976354 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.64 8.98 0.48 5.26e-17 Total body bone mineral density; CESC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg14061069 chr19:46274453 DMPK 0.52 8.23 0.45 8.37e-15 Coronary artery disease; CESC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg12311346 chr5:56204834 C5orf35 0.42 5.32 0.31 2.24e-7 Coronary artery disease; CESC cis rs8028182 0.636 rs28623700 chr15:75849714 T/A cg20655648 chr15:75932815 IMP3 0.49 6.04 0.35 5.32e-9 Sudden cardiac arrest; CESC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.63 8.92 0.48 7.86e-17 Bipolar disorder; CESC cis rs7267979 0.966 rs2261785 chr20:25262403 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.18e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs7208859 0.524 rs11653605 chr17:29088385 T/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9611565 0.568 rs2413656 chr22:42129357 G/T cg06634786 chr22:41940651 POLR3H 0.45 5.09 0.3 6.82e-7 Vitiligo; CESC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg05890377 chr2:74357713 NA 0.72 9.58 0.51 7.61e-19 Gestational age at birth (maternal effect); CESC cis rs4901869 0.966 rs431343 chr14:59345530 C/T cg02291164 chr14:59296302 NA 0.42 7.11 0.4 1.06e-11 Panic disorder; CESC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.68 -8.35 -0.46 3.76e-15 Mean platelet volume; CESC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg04944784 chr2:26401820 FAM59B -0.93 -10.7 -0.55 1.94e-22 Gut microbiome composition (summer); CESC cis rs459571 0.606 rs457420 chr9:136909261 A/G cg13789015 chr9:136890014 NCRNA00094 -0.48 -7.32 -0.41 2.89e-12 Platelet distribution width; CESC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg22920501 chr2:26401640 FAM59B 0.65 7.92 0.44 6.66e-14 Gut microbiome composition (summer); CESC cis rs9303401 0.659 rs17822735 chr17:56620167 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.92 0.62 6.16e-30 Cognitive test performance; CESC cis rs2014572 0.933 rs8107516 chr19:57758445 A/G cg12963866 chr19:57752005 ZNF805 -0.46 -6.15 -0.35 2.82e-9 Hyperactive-impulsive symptoms; CESC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg03806693 chr22:41940476 POLR3H -1.22 -16.24 -0.71 1.23e-41 Vitiligo; CESC cis rs78456975 1.000 rs28742145 chr2:1562671 T/C cg01028140 chr2:1542097 TPO -0.5 -5.35 -0.31 1.89e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs963731 0.522 rs297128 chr2:39298403 C/G cg04010122 chr2:39346883 SOS1 -0.76 -5.76 -0.33 2.32e-8 Corticobasal degeneration; CESC cis rs2991971 0.810 rs12119202 chr1:45925931 A/T cg15605315 chr1:45957053 TESK2 -0.39 -5.31 -0.31 2.28e-7 High light scatter reticulocyte count; CESC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg20203395 chr5:56204925 C5orf35 -0.52 -6.0 -0.35 6.42e-9 Initial pursuit acceleration; CESC cis rs1865721 0.682 rs35282535 chr18:73141206 G/A cg26385618 chr18:73139727 C18orf62 -0.48 -7.73 -0.43 2.24e-13 Intelligence; CESC cis rs16867321 0.950 rs1919148 chr2:181501758 G/A cg23363182 chr2:181467187 NA -0.43 -5.69 -0.33 3.39e-8 Obesity; CESC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg16339924 chr4:17578868 LAP3 0.54 6.64 0.38 1.76e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6963495 0.818 rs73192113 chr7:105169603 C/T cg19920283 chr7:105172520 RINT1 0.69 6.54 0.37 3.15e-10 Bipolar disorder (body mass index interaction); CESC cis rs1707322 1.000 rs4073847 chr1:46463012 A/C cg06784218 chr1:46089804 CCDC17 -0.36 -6.18 -0.35 2.45e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7845219 0.544 rs10956932 chr8:95948202 C/T cg09323728 chr8:95962352 TP53INP1 0.28 5.47 0.32 1.02e-7 Type 2 diabetes; CESC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg21724239 chr8:58056113 NA 0.6 5.48 0.32 1e-7 Developmental language disorder (linguistic errors); CESC cis rs11822910 0.911 rs61886978 chr11:57194848 G/C cg00522883 chr11:57194120 SLC43A3 0.57 6.77 0.38 8.46e-11 Platelet distribution width; CESC cis rs72945132 0.882 rs7928686 chr11:70134528 T/C cg00319359 chr11:70116639 PPFIA1 0.78 7.74 0.43 2.13e-13 Coronary artery disease; CESC cis rs4555082 0.834 rs2816652 chr14:105712493 C/T cg13114125 chr14:105738426 BRF1 -0.81 -9.8 -0.52 1.56e-19 Mean platelet volume;Platelet distribution width; CESC cis rs763121 0.925 rs9835 chr22:39130971 A/G cg06544989 chr22:39130855 UNC84B 0.44 8.08 0.44 2.27e-14 Menopause (age at onset); CESC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg13395646 chr4:1353034 KIAA1530 -0.49 -6.32 -0.36 1.08e-9 Obesity-related traits; CESC cis rs1707322 0.717 rs10890345 chr1:46213927 C/T cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs34375054 0.624 rs12580033 chr12:125676083 A/T cg25124228 chr12:125621409 AACS -0.46 -5.24 -0.31 3.23e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg06420487 chr17:61919686 SMARCD2 0.47 5.63 0.33 4.6e-8 Height; CESC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.75 0.77 5.46e-54 Height; CESC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg25204440 chr1:209979598 IRF6 0.62 8.03 0.44 3.12e-14 Cleft lip with or without cleft palate; CESC cis rs9916302 0.904 rs4794813 chr17:37670994 A/T cg00129232 chr17:37814104 STARD3 -0.51 -6.4 -0.37 7.19e-10 Glomerular filtration rate (creatinine); CESC cis rs1153858 1.000 rs7167900 chr15:45639471 A/G cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs7937682 0.883 rs549143 chr11:111463779 C/T cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC cis rs10779751 0.960 rs6661859 chr1:11301063 T/C cg08854313 chr1:11322531 MTOR 0.84 11.96 0.59 1.16e-26 Body mass index; CESC cis rs6964587 0.967 rs7783414 chr7:91785957 C/T cg17063962 chr7:91808500 NA 0.58 8.04 0.44 2.92e-14 Breast cancer; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg17156276 chr1:44126005 KDM4A 0.39 6.09 0.35 4e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs938554 0.612 rs4385059 chr4:9989233 A/G cg11266682 chr4:10021025 SLC2A9 -0.46 -6.03 -0.35 5.49e-9 Blood metabolite levels; CESC cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg19077165 chr18:44547161 KATNAL2 -0.63 -9.53 -0.51 1.07e-18 Personality dimensions; CESC cis rs72627123 0.867 rs73303135 chr14:74495090 C/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.68 0.33 3.63e-8 Morning vs. evening chronotype; CESC cis rs7130144 0.534 rs74855511 chr11:130460751 G/A cg26307797 chr11:130446613 NA -0.8 -6.53 -0.37 3.43e-10 Urate levels in lean individuals; CESC cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg27572855 chr1:25598939 RHD 0.43 7.14 0.4 9.07e-12 Plateletcrit;Mean corpuscular volume; CESC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -10.98 -0.56 2.26e-23 Initial pursuit acceleration; CESC cis rs12410462 1.000 rs80168344 chr1:227655804 C/T cg04117972 chr1:227635322 NA 0.63 6.25 0.36 1.61e-9 Major depressive disorder; CESC cis rs75804782 0.521 rs113497020 chr2:239370813 C/T cg18131467 chr2:239335373 ASB1 -0.73 -5.69 -0.33 3.41e-8 Morning vs. evening chronotype;Chronotype; CESC trans rs11098499 0.908 rs11729050 chr4:120300066 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC trans rs10506458 0.915 rs12426017 chr12:63396272 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.35 -18.82 -0.76 9.08e-51 Hemostatic factors and hematological phenotypes; CESC cis rs7914558 0.966 rs12569617 chr10:104729996 T/C cg04362960 chr10:104952993 NT5C2 0.45 5.76 0.33 2.33e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg03433033 chr1:76189801 ACADM 0.71 9.79 0.52 1.65e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg08888203 chr3:10149979 C3orf24 0.53 6.83 0.39 5.8200000000000003e-11 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13039021 chr17:80888278 TBCD 0.49 6.81 0.39 6.53e-11 Fibrinogen levels; CESC trans rs561341 1.000 rs501957 chr17:30314504 C/T cg27661571 chr11:113659931 NA -0.8 -7.48 -0.42 1.08e-12 Hip circumference adjusted for BMI; CESC cis rs2629540 0.806 rs10901812 chr10:126419384 A/G cg08799069 chr10:126477246 METTL10 -0.6 -7.88 -0.44 8.49e-14 Cocaine dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26149738 chr19:34287125 KCTD15 -0.51 -6.18 -0.35 2.37e-9 Gut microbiome composition (summer); CESC cis rs10751667 0.643 rs7396951 chr11:927355 G/A cg06064525 chr11:970664 AP2A2 -0.52 -10.25 -0.53 5.74e-21 Alzheimer's disease (late onset); CESC cis rs4660306 0.961 rs12145526 chr1:45969036 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.86e-13 Homocysteine levels; CESC cis rs6964587 0.933 rs13230837 chr7:91779017 A/G cg17063962 chr7:91808500 NA 0.55 7.54 0.42 7.56e-13 Breast cancer; CESC cis rs7917772 0.582 rs10786680 chr10:104317192 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 5.59 0.32 5.61e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg00815214 chr21:47717953 NA 0.35 5.3 0.31 2.39e-7 Testicular germ cell tumor; CESC cis rs7116495 0.609 rs2511120 chr11:71786211 C/T cg26138937 chr11:71823887 C11orf51 -1.3 -7.96 -0.44 4.95e-14 Severe influenza A (H1N1) infection; CESC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg15782153 chr7:917662 C7orf20 -0.49 -5.41 -0.32 1.4e-7 Cerebrospinal P-tau181p levels; CESC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg24829409 chr8:58192753 C8orf71 -0.65 -7.36 -0.41 2.29e-12 Developmental language disorder (linguistic errors); CESC cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC cis rs7208859 0.623 rs216439 chr17:28927884 T/C cg14008862 chr17:28927542 LRRC37B2 0.73 5.52 0.32 8.23e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3924048 0.559 rs6541037 chr1:12626155 A/G cg00291366 chr1:12616550 NA 0.36 6.3 0.36 1.23e-9 Optic cup area; CESC cis rs67366981 0.800 rs55939042 chr14:77691186 T/A cg22824376 chr14:77648248 TMEM63C 0.71 5.89 0.34 1.18e-8 Obsessive-compulsive symptoms; CESC cis rs644148 0.730 rs2117383 chr19:44978298 A/C cg15540054 chr19:45004280 ZNF180 0.61 6.74 0.38 1e-10 Personality dimensions; CESC cis rs8062405 0.755 rs4788076 chr16:28570005 C/T cg07382826 chr16:28625726 SULT1A1 0.39 6.46 0.37 4.92e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.34 0.5 3.98e-18 Menopause (age at onset); CESC cis rs7605827 0.930 rs13016997 chr2:15699240 A/T cg19274914 chr2:15703543 NA 0.36 6.45 0.37 5.2e-10 Educational attainment (years of education); CESC cis rs116095464 0.510 rs60844864 chr5:267000 A/G cg22857025 chr5:266934 NA -1.31 -18.31 -0.75 6.05e-49 Breast cancer; CESC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg15445000 chr17:37608096 MED1 0.41 6.81 0.39 6.64e-11 Glomerular filtration rate (creatinine); CESC cis rs713587 0.626 rs62140636 chr2:25233811 T/C cg01884057 chr2:25150051 NA -0.38 -7.26 -0.41 4.32e-12 Body mass index in non-asthmatics; CESC cis rs17253792 0.822 rs79873916 chr14:56172631 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg23708337 chr7:1209742 NA 0.52 5.27 0.31 2.85e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10751667 0.961 rs6597971 chr11:928598 T/A cg01483505 chr11:975446 AP2A2 0.39 5.07 0.3 7.63e-7 Alzheimer's disease (late onset); CESC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg12463550 chr7:65579703 CRCP -0.49 -6.42 -0.37 6.41e-10 Aortic root size; CESC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg11644478 chr21:40555479 PSMG1 1.01 15.97 0.7 1.12e-40 Cognitive function; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg18652453 chr5:68665041 TAF9;RAD17 -0.57 -6.49 -0.37 4.27e-10 Gut microbiota (bacterial taxa); CESC cis rs2204008 0.665 rs11179830 chr12:38220966 T/C cg13010199 chr12:38710504 ALG10B 0.48 5.88 0.34 1.25e-8 Bladder cancer; CESC cis rs2749592 0.531 rs994804 chr10:37900140 A/C cg25427524 chr10:38739819 LOC399744 0.56 7.89 0.44 7.91e-14 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg06877462 chr1:205807181 PM20D1 0.37 5.35 0.31 1.88e-7 Menarche (age at onset); CESC cis rs933688 0.526 rs9293565 chr5:90609736 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.53 5.83 0.34 1.6e-8 Smoking behavior; CESC cis rs9303280 0.806 rs4795395 chr17:37962987 T/A cg20243544 chr17:37824526 PNMT 0.52 7.01 0.4 1.99e-11 Self-reported allergy; CESC cis rs7264396 0.790 rs6121020 chr20:34252006 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 2.93e-26 Total cholesterol levels; CESC cis rs4474465 0.688 rs7937225 chr11:78278126 T/A cg27205649 chr11:78285834 NARS2 0.52 7.06 0.4 1.5e-11 Alzheimer's disease (survival time); CESC cis rs10028773 0.515 rs9994651 chr4:120587803 C/T cg09307838 chr4:120376055 NA 0.68 8.94 0.48 6.92e-17 Educational attainment; CESC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg04369109 chr6:150039330 LATS1 -0.46 -6.28 -0.36 1.4e-9 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21953508 chr4:38690502 KLF3 -0.58 -6.27 -0.36 1.45e-9 Gut microbiome composition (summer); CESC trans rs1728785 1.000 rs1170433 chr16:68606081 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.93 0.44 6e-14 Ulcerative colitis; CESC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg24531977 chr5:56204891 C5orf35 -0.88 -11.7 -0.58 9.28e-26 Initial pursuit acceleration; CESC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.07 -0.3 7.42e-7 Total body bone mineral density; CESC cis rs212524 0.544 rs2038089 chr1:21551457 C/T cg05370193 chr1:21551575 ECE1 -0.41 -6.6 -0.38 2.18e-10 Height; CESC cis rs6500602 0.701 rs1362626 chr16:4549226 C/G cg08645402 chr16:4508243 NA 0.43 6.81 0.39 6.57e-11 Schizophrenia; CESC cis rs9926296 0.632 rs7206546 chr16:89799079 C/T cg27121462 chr16:89883253 FANCA -0.63 -8.05 -0.44 2.77e-14 Vitiligo; CESC cis rs56104184 0.775 rs117744769 chr19:49402686 G/T cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs4835473 0.900 rs34569841 chr4:144659213 C/A cg25736465 chr4:144833511 NA -0.32 -5.16 -0.3 4.85e-7 Immature fraction of reticulocytes; CESC cis rs13082711 0.522 rs9310842 chr3:27369765 A/T cg02860705 chr3:27208620 NA -0.51 -6.69 -0.38 1.34e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.6 7.77 0.43 1.78e-13 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00852768 chr6:163834924 QKI 0.6 7.07 0.4 1.39e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg18180107 chr4:99064573 C4orf37 0.42 5.5 0.32 9.08e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs7503069 chr17:37697128 C/G cg07936489 chr17:37558343 FBXL20 -0.8 -11.62 -0.58 1.73e-25 Glomerular filtration rate (creatinine); CESC cis rs9894429 0.752 rs6565610 chr17:79592652 A/G cg13777783 chr17:79615861 NA -0.33 -5.23 -0.31 3.45e-7 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14715482 chr5:10377171 MARCH6 -0.59 -6.38 -0.36 7.84e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg04944784 chr2:26401820 FAM59B -0.96 -10.55 -0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs9314614 0.901 rs2978902 chr8:6690173 C/G cg27319216 chr8:6693540 XKR5 0.39 5.7 0.33 3.24e-8 IgA nephropathy;White blood cell count (basophil); CESC cis rs7560272 0.538 rs7370393 chr2:73925636 A/C cg20560298 chr2:73613845 ALMS1 0.45 6.26 0.36 1.51e-9 Schizophrenia; CESC cis rs7949030 0.588 rs2509961 chr11:62310909 T/C cg13298116 chr11:62369859 EML3;MTA2 0.58 8.57 0.47 8.59e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg08888203 chr3:10149979 C3orf24 0.46 5.94 0.34 8.69e-9 Alzheimer's disease; CESC cis rs854765 0.583 rs11078404 chr17:17820487 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.56 7.99 0.44 4.08e-14 Total body bone mineral density; CESC cis rs11764590 0.694 rs6461115 chr7:2103668 A/G cg21782813 chr7:2030301 MAD1L1 -0.39 -5.11 -0.3 6.14e-7 Neuroticism; CESC cis rs4900538 0.963 rs1190554 chr14:102918686 T/C cg18135206 chr14:102964638 TECPR2 0.76 10.01 0.52 3.22e-20 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs11098499 0.754 rs9999724 chr4:120239944 C/T cg25214090 chr10:38739885 LOC399744 0.64 9.1 0.49 2.29e-17 Corneal astigmatism; CESC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg08888203 chr3:10149979 C3orf24 0.49 6.17 0.35 2.51e-9 Alzheimer's disease; CESC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg22105103 chr4:187893119 NA 0.5 7.43 0.42 1.48e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7107174 1.000 rs2244508 chr11:77948515 T/A cg03754400 chr11:77348600 CLNS1A 0.47 5.08 0.3 7e-7 Testicular germ cell tumor; CESC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg26879891 chr1:152191343 HRNR -0.42 -6.51 -0.37 3.72e-10 Inflammatory skin disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15697355 chr19:6414982 KHSRP -0.51 -6.18 -0.35 2.37e-9 Gut microbiome composition (summer); CESC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs8031584 0.958 rs34909055 chr15:31284170 C/T cg08109568 chr15:31115862 NA -0.58 -7.53 -0.42 7.77e-13 Huntington's disease progression; CESC cis rs67478160 0.572 rs8015603 chr14:104293678 C/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.57 0.54 5.25e-22 Schizophrenia; CESC cis rs3008870 0.755 rs2815368 chr1:67500778 C/T cg02640540 chr1:67518911 SLC35D1 0.46 5.64 0.33 4.33e-8 Lymphocyte percentage of white cells; CESC cis rs11711311 1.000 rs1073040 chr3:113522123 C/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.58 7.63 0.42 4.27e-13 IgG glycosylation; CESC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg11060661 chr22:24314208 DDT;DDTL 0.32 5.1 0.3 6.41e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs8114671 0.869 rs2038503 chr20:33675900 G/A cg24642439 chr20:33292090 TP53INP2 -0.47 -5.62 -0.33 4.82e-8 Height; CESC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs933688 1.000 rs10045280 chr5:90717675 T/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.08 14.34 0.66 6.68e-35 Smoking behavior; CESC cis rs7312933 0.528 rs10880238 chr12:42489613 A/G cg17420585 chr12:42539391 GXYLT1 -0.34 -5.07 -0.3 7.33e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.36 0.5 3.44e-18 Menopause (age at onset); CESC cis rs9926296 0.593 rs6500456 chr16:89888341 T/C cg04287289 chr16:89883240 FANCA 0.6 7.91 0.44 6.93e-14 Vitiligo; CESC cis rs9435341 0.896 rs1730850 chr1:107597988 C/T cg09367891 chr1:107599246 PRMT6 -0.71 -8.41 -0.46 2.5e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs2072732 0.821 rs12039548 chr1:2947909 C/T cg15211996 chr1:2936768 ACTRT2 -0.33 -5.63 -0.33 4.66e-8 Plateletcrit; CESC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.46 6.22 0.36 1.96e-9 Bipolar disorder; CESC cis rs6982240 0.514 rs9324543 chr8:142275662 T/C cg27411547 chr8:142287226 NA -0.53 -7.4 -0.41 1.76e-12 Tonsillectomy; CESC cis rs10754283 0.901 rs10922683 chr1:90116068 G/A cg21401794 chr1:90099060 LRRC8C 0.7 9.37 0.5 3.37e-18 Amyotrophic lateral sclerosis (sporadic); CESC trans rs11039798 0.557 rs683180 chr11:48463949 A/G cg15704280 chr7:45808275 SEPT13 -0.6 -6.32 -0.36 1.11e-9 Axial length; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14806418 chr10:131904271 NA 0.48 6.77 0.38 8.05e-11 Fibrinogen levels; CESC cis rs3767633 0.925 rs10737502 chr1:161792321 G/A cg09175582 chr1:161736000 ATF6 0.77 6.03 0.35 5.38e-9 IgG glycosylation; CESC cis rs8180040 0.726 rs2305638 chr3:47046842 G/C cg27129171 chr3:47204927 SETD2 0.69 10.3 0.53 3.86e-21 Colorectal cancer; CESC cis rs2439831 1.000 rs561863 chr15:43761352 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.17 0.6 2.26e-27 Lung cancer in ever smokers; CESC cis rs4699052 0.590 rs1156669 chr4:104288204 A/C cg16532752 chr4:104119610 CENPE -0.38 -5.34 -0.31 1.98e-7 Testicular germ cell tumor; CESC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg25405998 chr7:65216604 CCT6P1 -0.44 -5.61 -0.33 5.04e-8 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13114696 chr21:47808953 PCNT -0.53 -6.11 -0.35 3.48e-9 Gut microbiome composition (summer); CESC cis rs2191566 0.576 rs448692 chr19:44494730 A/G cg20607764 chr19:44506953 ZNF230 -0.45 -5.63 -0.33 4.66e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs938554 0.692 rs13111638 chr4:9996890 A/G cg00071950 chr4:10020882 SLC2A9 0.6 6.4 0.37 6.98e-10 Blood metabolite levels; CESC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg26587870 chr6:27730563 NA -0.6 -5.29 -0.31 2.58e-7 Depression; CESC cis rs6973256 0.605 rs13237435 chr7:133347570 C/T cg10665199 chr7:133106180 EXOC4 -0.47 -6.34 -0.36 9.86e-10 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03891344 chr16:19533212 GDE1 0.5 6.34 0.36 1.01e-9 Gut microbiota (bacterial taxa); CESC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 12.51 0.61 1.61e-28 Alzheimer's disease; CESC cis rs12618769 0.597 rs17031139 chr2:99036530 A/G cg10123293 chr2:99228465 UNC50 -0.41 -5.42 -0.32 1.36e-7 Bipolar disorder; CESC cis rs2011503 0.941 rs56044734 chr19:19366927 G/A cg11584989 chr19:19387371 SF4 0.6 7.23 0.41 5.2e-12 Bipolar disorder; CESC cis rs4808199 0.948 rs757001 chr19:19448808 G/A cg03709012 chr19:19516395 GATAD2A 1.14 12.23 0.6 1.49e-27 Nonalcoholic fatty liver disease; CESC cis rs7098414 0.511 rs10749592 chr10:82150891 C/T cg00277334 chr10:82204260 NA -0.5 -7.53 -0.42 7.97e-13 Post bronchodilator FEV1; CESC cis rs9325144 0.647 rs11168104 chr12:38857616 G/T cg26384229 chr12:38710491 ALG10B -0.56 -7.89 -0.44 8.02e-14 Morning vs. evening chronotype; CESC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg21361702 chr7:150065534 REPIN1 0.58 6.05 0.35 5.02e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs7726839 0.540 rs72703078 chr5:594987 A/C cg16447950 chr5:562315 NA -0.6 -6.08 -0.35 4.21e-9 Obesity-related traits; CESC cis rs3733585 0.762 rs6449217 chr4:10009151 T/A cg11266682 chr4:10021025 SLC2A9 0.67 12.64 0.61 5.55e-29 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05596626 chr16:22277970 EEF2K -0.52 -6.02 -0.35 5.7e-9 Gut microbiome composition (summer); CESC cis rs999943 0.846 rs1570760 chr6:33622933 C/T cg14003231 chr6:33640908 ITPR3 0.69 12.08 0.6 4.81e-27 Obesity (extreme); CESC cis rs11864453 0.611 rs1050361 chr16:72130203 C/G cg01557791 chr16:72042693 DHODH -0.43 -5.63 -0.33 4.52e-8 Fibrinogen levels; CESC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg12463550 chr7:65579703 CRCP -0.5 -6.43 -0.37 5.82e-10 Aortic root size; CESC cis rs1707322 0.716 rs6699444 chr1:46135120 G/C cg05343316 chr1:45956843 TESK2 0.51 6.24 0.36 1.7e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg14262678 chr6:151773367 RMND1;C6orf211 0.67 9.57 0.51 8.08e-19 Menarche (age at onset); CESC cis rs782590 0.807 rs782572 chr2:55912120 T/C cg18811423 chr2:55921094 PNPT1 0.8 12.84 0.62 1.18e-29 Metabolic syndrome; CESC cis rs7267979 0.844 rs4815413 chr20:25359229 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -14.75 -0.67 2.44e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs6496667 0.730 rs7176776 chr15:91049140 T/G cg13834112 chr15:90361639 NA 0.41 5.38 0.31 1.68e-7 Rheumatoid arthritis; CESC cis rs11786130 1.000 rs4733812 chr8:128999640 C/T cg01765152 chr8:129005526 PVT1 -0.33 -5.39 -0.31 1.54e-7 Eosinophil counts;Sum eosinophil basophil counts; CESC cis rs593982 1.000 rs576663 chr11:65498942 G/T cg08755490 chr11:65554678 OVOL1 1.31 20.14 0.78 2.41e-55 Atopic dermatitis; CESC cis rs7809950 0.817 rs17154091 chr7:107084790 T/C cg23024343 chr7:107201750 COG5 -0.55 -7.11 -0.4 1.05e-11 Coronary artery disease; CESC cis rs9796 0.870 rs3214068 chr15:41313064 C/G cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.89 -0.39 4e-11 Menopause (age at onset); CESC cis rs863345 0.604 rs6669271 chr1:158471999 A/G cg12129480 chr1:158549410 OR10X1 -0.36 -7.44 -0.42 1.39e-12 Pneumococcal bacteremia; CESC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg22903657 chr4:1355424 KIAA1530 -0.38 -5.23 -0.31 3.48e-7 Obesity-related traits; CESC trans rs66573146 1.000 rs56074877 chr4:6990374 C/T cg07817883 chr1:32538562 TMEM39B 1.09 7.0 0.4 2.06e-11 Granulocyte percentage of myeloid white cells; CESC cis rs13191362 0.507 rs6936804 chr6:163069424 A/T cg21926612 chr6:163149169 PACRG;PARK2 -0.59 -7.07 -0.4 1.34e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8103278 0.507 rs522769 chr19:46284520 G/A cg12641515 chr19:46296257 DMWD 0.72 9.4 0.5 2.67e-18 Coronary artery disease; CESC cis rs9715521 0.677 rs11944208 chr4:59860652 G/A cg11281224 chr4:60001000 NA -0.56 -7.8 -0.43 1.39e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg16680214 chr1:154839983 KCNN3 -0.45 -6.94 -0.39 3.06e-11 Prostate cancer; CESC cis rs7216064 0.953 rs11868959 chr17:65840810 T/C cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.73e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10751667 0.666 rs7124480 chr11:971601 G/A cg06064525 chr11:970664 AP2A2 -0.5 -9.85 -0.52 1.08e-19 Alzheimer's disease (late onset); CESC cis rs965469 1.000 rs6051762 chr20:3321590 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -5.61 -0.33 5.15e-8 IFN-related cytopenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04408576 chr16:1524927 CLCN7 0.59 6.67 0.38 1.5e-10 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs6460260 chr7:65215455 T/C cg13147721 chr7:65941812 NA 0.88 8.1 0.45 1.96e-14 Diabetic kidney disease; CESC cis rs1475911 0.708 rs56109792 chr21:43520060 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 0.99 13.67 0.64 1.47e-32 IgG glycosylation; CESC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.55 0.37 2.89e-10 Bipolar disorder; CESC cis rs1443512 0.812 rs1975472 chr12:54337083 A/G cg17410650 chr12:54324560 NA -0.48 -8.07 -0.44 2.5e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs524281 0.861 rs11227411 chr11:65879478 C/T cg14036092 chr11:66035641 RAB1B -0.63 -6.43 -0.37 5.84e-10 Electroencephalogram traits; CESC trans rs6076960 0.509 rs3747923 chr20:6182577 C/T cg27123975 chr17:57697125 CLTC -0.49 -6.03 -0.35 5.56e-9 Smooth-surface caries; CESC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg09509183 chr1:209979624 IRF6 0.56 5.86 0.34 1.4e-8 Cleft lip with or without cleft palate; CESC cis rs1557765 0.527 rs4756887 chr11:17394597 T/G cg15432903 chr11:17409602 KCNJ11 0.43 6.21 0.36 2e-9 Body mass index;Social communication problems; CESC cis rs919433 0.963 rs7582736 chr2:198170342 A/G cg03934865 chr2:198174659 NA -0.41 -5.46 -0.32 1.11e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs77741769 0.529 rs525425 chr12:121195625 A/G cg02419362 chr12:121203948 SPPL3 0.34 5.5 0.32 9e-8 Mean corpuscular volume; CESC cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg22764044 chr5:178986830 RUFY1 0.41 5.61 0.33 4.96e-8 Lung cancer; CESC cis rs7648466 0.592 rs7616215 chr3:46205686 A/G cg19145607 chr3:45983792 CXCR6;FYCO1 -0.36 -5.52 -0.32 8e-8 Eotaxin levels; CESC cis rs7680126 0.500 rs11735668 chr4:10148655 C/G cg00071950 chr4:10020882 SLC2A9 -0.57 -6.29 -0.36 1.3e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs2243480 0.615 rs34363376 chr7:65939536 T/C cg13147721 chr7:65941812 NA -0.94 -8.65 -0.47 4.93e-16 Diabetic kidney disease; CESC cis rs9303280 0.743 rs2941522 chr17:37910368 C/T cg20243544 chr17:37824526 PNMT -0.53 -7.32 -0.41 3.05e-12 Self-reported allergy; CESC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg10295955 chr4:187884368 NA 1.03 18.84 0.76 8.28e-51 Lobe attachment (rater-scored or self-reported); CESC cis rs733175 0.855 rs10016075 chr4:10006663 G/T cg11266682 chr4:10021025 SLC2A9 0.39 5.21 0.3 3.88e-7 Psychosis and Alzheimer's disease; CESC cis rs2243480 1.000 rs36033484 chr7:65390558 T/G cg13147721 chr7:65941812 NA -0.88 -8.15 -0.45 1.47e-14 Diabetic kidney disease; CESC cis rs7264396 0.563 rs2425136 chr20:34344782 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.68 7.27 0.41 3.97e-12 Total cholesterol levels; CESC cis rs116095464 0.558 rs10462755 chr5:246748 T/C cg10591111 chr5:226296 SDHA -0.51 -6.28 -0.36 1.38e-9 Breast cancer; CESC cis rs7635838 0.892 rs34830847 chr3:11437798 A/C cg00170343 chr3:11313890 ATG7 0.42 5.54 0.32 7.14e-8 HDL cholesterol; CESC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.03e-9 Aortic root size; CESC cis rs7208859 0.623 rs216423 chr17:28942109 G/C cg19761014 chr17:28927070 LRRC37B2 0.79 7.49 0.42 1.06e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4555082 0.874 rs2816606 chr14:105716034 C/T cg06808227 chr14:105710500 BRF1 -0.51 -5.79 -0.34 1.96e-8 Mean platelet volume;Platelet distribution width; CESC cis rs57506017 0.585 rs6966757 chr7:12265952 A/T cg23422036 chr7:12250390 TMEM106B 0.38 5.11 0.3 6.03e-7 Neuroticism; CESC cis rs78456975 1.000 rs10205916 chr2:1558451 A/T cg01028140 chr2:1542097 TPO 0.54 5.64 0.33 4.38e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs208520 0.874 rs208514 chr6:66945520 G/A cg07460842 chr6:66804631 NA -0.82 -9.87 -0.52 8.78e-20 Exhaled nitric oxide output; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21395147 chr1:211849137 NEK2 -0.44 -6.01 -0.35 5.98e-9 Fibrinogen levels; CESC cis rs6500602 0.701 rs11643057 chr16:4544505 C/T cg08645402 chr16:4508243 NA 0.44 6.86 0.39 4.83e-11 Schizophrenia; CESC cis rs2243480 0.803 rs34004500 chr7:65312178 A/T cg18252515 chr7:66147081 NA -1.01 -9.73 -0.51 2.51e-19 Diabetic kidney disease; CESC cis rs3857067 0.806 rs2171384 chr4:95103545 G/A cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.01 -0.48 4.22e-17 QT interval; CESC cis rs447 0.895 rs1468345 chr7:83748974 A/G cg22846510 chr7:83753280 SEMA3A -0.48 -5.87 -0.34 1.27e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09580147 chr16:22431764 RRN3P3 -0.57 -7.35 -0.41 2.54e-12 Gut microbiome composition (summer); CESC cis rs9549367 0.774 rs9549696 chr13:113875062 C/T cg00898013 chr13:113819073 PROZ -0.51 -7.25 -0.41 4.57e-12 Platelet distribution width; CESC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg19163074 chr7:65112434 INTS4L2 0.46 5.05 0.3 8.07e-7 Aortic root size; CESC cis rs2243480 1.000 rs35421653 chr7:65363429 C/A cg18252515 chr7:66147081 NA -1.18 -10.99 -0.56 2.15e-23 Diabetic kidney disease; CESC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg00339695 chr16:24857497 SLC5A11 -0.52 -6.69 -0.38 1.34e-10 Intelligence (multi-trait analysis); CESC cis rs34779708 0.897 rs12764820 chr10:35386321 G/A cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs3960554 0.808 rs57721466 chr7:75710049 C/T cg17325771 chr7:75508891 RHBDD2 -0.37 -5.38 -0.31 1.68e-7 Eotaxin levels; CESC cis rs7965445 0.892 rs61937079 chr12:131928863 G/A cg08164151 chr12:131118432 NA 0.66 5.06 0.3 7.98e-7 Mortality in heart failure; CESC cis rs873946 0.504 rs12775990 chr10:134575836 C/T cg18305652 chr10:134549665 INPP5A 0.47 6.64 0.38 1.76e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg04511125 chr2:88470314 THNSL2 0.68 6.66 0.38 1.61e-10 Plasma clusterin levels; CESC cis rs72781680 0.898 rs72786276 chr2:24062566 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.86 0.39 4.98e-11 Lymphocyte counts; CESC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs10870270 1.000 rs7077744 chr10:133770201 C/T cg08754478 chr10:133766260 PPP2R2D -0.59 -7.57 -0.42 6.29e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg01416388 chr22:39784598 NA -0.58 -7.27 -0.41 4.15e-12 Intelligence (multi-trait analysis); CESC cis rs7208859 0.623 rs11656844 chr17:29060597 G/T cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12586317 0.547 rs12435454 chr14:35466997 A/G cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC cis rs5753618 0.583 rs2273251 chr22:31843567 G/C cg00478049 chr22:31556069 RNF185 -0.44 -5.23 -0.31 3.4e-7 Colorectal cancer; CESC trans rs8073060 0.586 rs6505487 chr17:33996850 A/G cg19694781 chr19:47549865 TMEM160 -0.74 -6.85 -0.39 5.24e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg19717773 chr7:2847554 GNA12 -0.45 -6.58 -0.37 2.44e-10 Height; CESC trans rs1493916 0.905 rs1586988 chr18:31396001 G/C cg27147174 chr7:100797783 AP1S1 -0.52 -6.92 -0.39 3.48e-11 Life satisfaction; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00923803 chr7:5862740 ZNF815 0.45 7.06 0.4 1.5e-11 Gut microbiota (bacterial taxa); CESC cis rs1008375 1.000 rs10939747 chr4:17691166 C/A cg02297831 chr4:17616191 MED28 0.5 5.88 0.34 1.24e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4654899 0.802 rs17449966 chr1:21203996 A/G cg05370193 chr1:21551575 ECE1 0.4 5.74 0.33 2.61e-8 Superior frontal gyrus grey matter volume; CESC cis rs5757673 1 rs5757673 chr22:39837920 T/C cg05872129 chr22:39784769 NA -0.86 -10.38 -0.54 2.09e-21 Post bronchodilator FEV1; CESC cis rs559928 0.606 rs11600628 chr11:63976027 C/T cg18225595 chr11:63971243 STIP1 0.67 6.16 0.35 2.67e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs5997397 0.967 rs5752791 chr22:29153547 A/G cg15103426 chr22:29168792 CCDC117 -0.43 -5.69 -0.33 3.44e-8 Red cell distribution width; CESC cis rs73129298 0.551 rs6020179 chr20:48604276 T/C cg25655593 chr20:48599521 SNAI1 0.49 5.22 0.31 3.67e-7 Inflammatory skin disease; CESC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.02 0.8 8.62e-62 Prudent dietary pattern; CESC cis rs1707322 0.721 rs7520123 chr1:46235219 C/G cg03146154 chr1:46216737 IPP 0.75 10.64 0.55 3.1e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12971120 0.891 rs71359051 chr18:72169723 G/A cg26446133 chr18:72167187 CNDP2 -0.76 -9.71 -0.51 2.84e-19 Refractive error; CESC cis rs1375194 0.582 rs13391166 chr2:33805314 C/T cg04131969 chr2:33951647 MYADML 0.52 6.67 0.38 1.45e-10 Response to antidepressants in depression; CESC cis rs1348850 0.914 rs1453370 chr2:178327727 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.88 12.54 0.61 1.28e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1348850 0.747 rs1047884 chr2:178488281 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 6.61 0.38 2.13e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg15445000 chr17:37608096 MED1 -0.41 -6.81 -0.39 6.37e-11 Glomerular filtration rate (creatinine); CESC cis rs4727027 0.704 rs10952805 chr7:148907849 G/A cg23583168 chr7:148888333 NA -0.93 -16.25 -0.71 1.16e-41 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg22535103 chr8:58192502 C8orf71 -0.93 -10.32 -0.54 3.27e-21 Developmental language disorder (linguistic errors); CESC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.46 0.42 1.24e-12 Tonsillectomy; CESC cis rs7769051 0.522 rs73554461 chr6:133139087 T/G cg22852734 chr6:133119734 C6orf192 0.91 6.59 0.38 2.4e-10 Type 2 diabetes nephropathy; CESC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4835473 0.864 rs4257604 chr4:144901414 G/C cg25736465 chr4:144833511 NA 0.41 6.2 0.36 2.14e-9 Immature fraction of reticulocytes; CESC trans rs17685 0.884 rs3823882 chr7:75631913 T/C cg19862616 chr7:65841803 NCRNA00174 -0.67 -8.69 -0.47 3.91e-16 Coffee consumption;Coffee consumption (cups per day); CESC cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg26441486 chr22:50317300 CRELD2 0.42 5.32 0.31 2.25e-7 Schizophrenia; CESC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg02592271 chr2:27665507 KRTCAP3 -0.36 -7.22 -0.41 5.53e-12 Total body bone mineral density; CESC cis rs12476592 0.571 rs1031221 chr2:63742810 C/T cg17519650 chr2:63277830 OTX1 0.47 5.32 0.31 2.18e-7 Childhood ear infection; CESC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg11764359 chr7:65958608 NA 0.79 11.19 0.57 4.69e-24 Aortic root size; CESC trans rs10242455 0.571 rs73713594 chr7:99326498 A/G cg09045935 chr12:6379348 NA 0.76 6.38 0.36 7.87e-10 Blood metabolite levels; CESC cis rs7089973 0.668 rs7077148 chr10:116644896 A/G cg23260525 chr10:116636907 FAM160B1 0.37 6.63 0.38 1.91e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6752107 1.000 rs2289472 chr2:234182240 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.37 5.58 0.32 5.94e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs6547741 1.000 rs1528404 chr2:27846603 C/T cg27432699 chr2:27873401 GPN1 -0.49 -6.81 -0.39 6.57e-11 Oral cavity cancer; CESC cis rs6912958 0.781 rs9444524 chr6:88311260 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.07 -0.3 7.45e-7 Monocyte percentage of white cells; CESC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg22764044 chr5:178986830 RUFY1 -0.47 -6.99 -0.39 2.29e-11 Lung cancer; CESC cis rs10129255 0.957 rs8009638 chr14:107185809 G/A cg23076370 chr14:107095027 NA -0.49 -6.18 -0.35 2.44e-9 Kawasaki disease; CESC cis rs2072499 0.722 rs61462713 chr1:156161682 C/T cg24450063 chr1:156163899 SLC25A44 0.98 11.99 0.59 9.64e-27 Testicular germ cell tumor; CESC cis rs6942407 0.649 rs6952384 chr7:86859551 T/C cg02420886 chr7:86849541 C7orf23 0.53 5.05 0.3 8.2e-7 Food allergy; CESC cis rs10751667 0.643 rs7396407 chr11:929374 A/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.26 -0.31 2.96e-7 Alzheimer's disease (late onset); CESC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs6912958 0.678 rs9450733 chr6:88250081 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.56 -0.37 2.75e-10 Monocyte percentage of white cells; CESC cis rs11640533 0.901 rs11862250 chr16:53415038 C/A cg08681685 chr16:53407594 NA 0.39 5.1 0.3 6.55e-7 Intelligence (multi-trait analysis); CESC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 10.62 0.55 3.59e-22 Platelet count; CESC cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg00033643 chr7:134001901 SLC35B4 0.44 5.66 0.33 3.97e-8 Mean platelet volume; CESC cis rs9790314 1.000 rs7638668 chr3:161047283 G/A cg04691961 chr3:161091175 C3orf57 -0.42 -5.31 -0.31 2.3e-7 Morning vs. evening chronotype; CESC cis rs2274273 0.840 rs28568813 chr14:55794114 C/G cg04306507 chr14:55594613 LGALS3 0.32 6.38 0.36 8.01e-10 Protein biomarker; CESC trans rs10776614 0.799 rs7071480 chr10:49764061 A/T cg19218067 chr2:181235115 NA 0.5 6.1 0.35 3.7e-9 Self-employment; CESC cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg20476274 chr7:133979776 SLC35B4 0.6 8.64 0.47 5.53e-16 Mean platelet volume; CESC cis rs9649465 1.000 rs1006764 chr7:123337873 C/T cg04330084 chr7:123175371 IQUB -0.37 -5.06 -0.3 7.81e-7 Migraine; CESC cis rs6963495 0.818 rs55983796 chr7:105170941 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.45 -0.32 1.13e-7 Bipolar disorder (body mass index interaction); CESC cis rs718433 0.584 rs10438076 chr14:22210067 T/C cg02257791 chr14:22217085 NA -0.33 -5.19 -0.3 4.29e-7 Intraocular pressure; CESC cis rs6815814 0.851 rs4274855 chr4:38777471 C/T cg02016764 chr4:38805732 TLR1 -0.68 -8.09 -0.45 2.13e-14 Breast cancer; CESC cis rs7107174 0.901 rs2510053 chr11:77959435 T/C cg27205649 chr11:78285834 NARS2 -0.4 -5.09 -0.3 6.88e-7 Testicular germ cell tumor; CESC cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg19717773 chr7:2847554 GNA12 -0.48 -7.22 -0.41 5.35e-12 Height; CESC cis rs28489187 0.706 rs233127 chr1:85793801 A/G cg16011679 chr1:85725395 C1orf52 0.49 5.76 0.33 2.39e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg20151795 chr6:28129481 ZNF389 -0.47 -6.09 -0.35 3.92e-9 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02458384 chr16:2021763 TBL3 0.64 7.22 0.41 5.45e-12 Gut microbiome composition (summer); CESC cis rs10752881 1.000 rs6658501 chr1:182991417 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.84 -13.21 -0.63 5.78e-31 Colorectal cancer; CESC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg12373951 chr3:133503437 NA 0.39 5.75 0.33 2.49e-8 Iron status biomarkers; CESC cis rs4629710 0.568 rs67021539 chr6:131552900 A/G cg12606694 chr6:131520996 AKAP7 0.49 6.1 0.35 3.78e-9 Multiple myeloma (IgH translocation); CESC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg18876405 chr7:65276391 NA -0.45 -6.18 -0.35 2.43e-9 Aortic root size; CESC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg04287289 chr16:89883240 FANCA 0.94 16.41 0.71 2.95e-42 Vitiligo; CESC cis rs9911578 0.835 rs723991 chr17:56482039 G/A cg12560992 chr17:57184187 TRIM37 -0.87 -14.48 -0.66 2.13e-35 Intelligence (multi-trait analysis); CESC trans rs17685 0.753 rs869806 chr7:75688623 C/T cg19862616 chr7:65841803 NCRNA00174 0.81 11.99 0.59 9.33e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs3008870 0.916 rs2025608 chr1:67422550 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs11792861 0.591 rs2282206 chr9:111746267 A/G cg13535736 chr9:111863775 C9orf5 -0.39 -5.62 -0.33 4.77e-8 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22251877 chr8:125551349 TATDN1;NDUFB9 0.59 6.46 0.37 5.04e-10 Gut microbiome composition (summer); CESC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08365438 chr10:21683093 NA 0.53 7.59 0.42 5.36e-13 Fibrinogen levels; CESC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7249142 0.549 rs10854012 chr19:19295719 C/T cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.3 5.35 0.31 1.91e-7 IgG glycosylation; CESC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.59 -0.32 5.57e-8 Aortic root size; CESC cis rs6500602 0.647 rs3747600 chr16:4586222 A/G cg08645402 chr16:4508243 NA 0.49 7.91 0.44 7.06e-14 Schizophrenia; CESC cis rs2228479 0.867 rs12930606 chr16:89946682 A/G cg04013166 chr16:89971882 TCF25 0.77 7.14 0.4 8.86e-12 Skin colour saturation; CESC cis rs10883723 0.962 rs1056740 chr10:104236552 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.34 0.41 2.67e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs8027181 0.959 rs11631352 chr15:73086473 A/G cg25632853 chr15:73088954 NA -0.33 -5.8 -0.34 1.85e-8 Triglyceride levels; CESC cis rs9399135 0.967 rs2297340 chr6:135376058 T/C cg22676075 chr6:135203613 NA 0.53 7.42 0.41 1.58e-12 Red blood cell count; CESC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.67 -0.33 3.74e-8 Total body bone mineral density; CESC cis rs909002 0.772 rs7525618 chr1:32073766 C/T cg13919466 chr1:32135498 COL16A1 -0.47 -8.52 -0.46 1.24e-15 Intelligence (multi-trait analysis); CESC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg10792982 chr14:105748885 BRF1 0.39 5.19 0.3 4.19e-7 Mean platelet volume;Platelet distribution width; CESC cis rs2795502 1.000 rs2473119 chr10:43339038 A/T cg27426351 chr10:43362370 NA -0.45 -5.5 -0.32 8.91e-8 Blood protein levels; CESC cis rs7116495 1.000 rs17161991 chr11:71839960 T/C cg10381502 chr11:71823885 C11orf51 0.7 5.7 0.33 3.17e-8 Severe influenza A (H1N1) infection; CESC cis rs7851660 0.933 rs894673 chr9:100612270 A/T cg13688889 chr9:100608707 NA -0.68 -10.64 -0.55 3.08e-22 Strep throat; CESC cis rs7249921 0.728 rs1627280 chr19:35652248 C/T cg15419183 chr19:35660584 FXYD5 0.43 6.78 0.38 7.58e-11 Platelet count; CESC cis rs9399135 0.844 rs13209789 chr6:135367916 A/G cg22676075 chr6:135203613 NA 0.51 7.29 0.41 3.6e-12 Red blood cell count; CESC cis rs425277 0.585 rs3128294 chr1:2065343 G/C cg19257562 chr1:2043853 PRKCZ 0.34 5.35 0.31 1.95e-7 Height; CESC cis rs4253772 0.591 rs6008384 chr22:46655948 T/C cg09491104 chr22:46646882 C22orf40 -0.6 -9.22 -0.49 9.82e-18 LDL cholesterol;Cholesterol, total; CESC cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg15605315 chr1:45957053 TESK2 0.5 6.62 0.38 1.96e-10 High light scatter reticulocyte count; CESC trans rs1814175 0.817 rs10769613 chr11:49769692 G/A cg03929089 chr4:120376271 NA -0.9 -14.81 -0.67 1.43e-36 Height; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16025584 chr9:139887217 C9orf142 0.48 6.5 0.37 4.02e-10 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24504843 chr4:56896641 CEP135 -0.58 -6.27 -0.36 1.46e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19758033 chr1:20987701 DDOST -0.46 -6.48 -0.37 4.35e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06397424 chr16:15737279 NDE1;KIAA0430 -0.5 -6.81 -0.39 6.35e-11 Asthma; CESC cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg18850127 chr7:39170497 POU6F2 0.39 5.49 0.32 9.55e-8 IgG glycosylation; CESC cis rs9616064 0.853 rs7284865 chr22:46996529 C/T cg05621596 chr22:47072043 GRAMD4 -0.51 -7.17 -0.4 7.33e-12 Urate levels in obese individuals; CESC cis rs3820068 0.506 rs17448966 chr1:15990983 T/G cg17385448 chr1:15911702 AGMAT 0.44 7.64 0.42 4.05e-13 Systolic blood pressure; CESC cis rs561341 1.000 rs473356 chr17:30321762 G/C cg12193833 chr17:30244370 NA -0.72 -6.68 -0.38 1.42e-10 Hip circumference adjusted for BMI; CESC cis rs9398803 0.865 rs4422634 chr6:126806676 A/G cg19875578 chr6:126661172 C6orf173 0.43 5.92 0.34 1.01e-8 Male-pattern baldness; CESC cis rs965469 0.895 rs6051841 chr20:3392871 A/G cg25506879 chr20:3388711 C20orf194 -0.63 -6.63 -0.38 1.92e-10 IFN-related cytopenia; CESC cis rs10189230 0.967 rs13012429 chr2:222350788 C/T cg14652038 chr2:222343519 EPHA4 0.36 7.56 0.42 6.58e-13 Urate levels in lean individuals; CESC cis rs1003719 0.679 rs2835638 chr21:38534533 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.06 -0.44 2.72e-14 Eye color traits; CESC cis rs4835473 0.932 rs11736609 chr4:144754029 G/A cg25736465 chr4:144833511 NA -0.45 -6.75 -0.38 9.22e-11 Immature fraction of reticulocytes; CESC cis rs9549260 0.739 rs7330614 chr13:41199421 G/A cg21288729 chr13:41239152 FOXO1 0.64 8.26 0.45 7.14e-15 Red blood cell count; CESC cis rs2228479 0.867 rs11642451 chr16:89958127 T/C cg04013166 chr16:89971882 TCF25 0.78 7.19 0.4 6.56e-12 Skin colour saturation; CESC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg22920501 chr2:26401640 FAM59B 0.92 10.43 0.54 1.42e-21 Gut microbiome composition (summer); CESC cis rs10754283 0.901 rs6663526 chr1:90110862 T/C cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs367943 0.698 rs10050530 chr5:112971042 A/C cg12552261 chr5:112820674 MCC 0.44 5.63 0.33 4.63e-8 Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21813473 chr20:40247231 CHD6 0.43 6.99 0.39 2.26e-11 Gambling; CESC cis rs11971779 0.793 rs11764426 chr7:139024050 C/G cg07862535 chr7:139043722 LUC7L2 0.49 5.58 0.32 6.08e-8 Diisocyanate-induced asthma; CESC cis rs9768139 0.708 rs10233815 chr7:158114348 C/T cg24154853 chr7:158122151 PTPRN2 0.41 6.44 0.37 5.53e-10 Calcium levels; CESC cis rs1832871 0.672 rs9457337 chr6:158726292 C/T cg07165851 chr6:158734300 TULP4 0.6 6.65 0.38 1.68e-10 Height; CESC cis rs2074585 0.839 rs11638780 chr15:91041896 G/T cg22089800 chr15:90895588 ZNF774 -0.65 -8.96 -0.48 5.83e-17 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs11098499 0.697 rs6832410 chr4:120296800 A/G cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23200371 chr12:56367680 RAB5B 0.57 6.09 0.35 3.92e-9 Gut microbiome composition (summer); CESC cis rs7843479 0.870 rs1809498 chr8:21836384 C/G cg17168535 chr8:21777572 XPO7 -0.55 -7.88 -0.44 8.6e-14 Mean corpuscular volume; CESC cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.76e-7 Colonoscopy-negative controls vs population controls; CESC trans rs116095464 0.510 rs60844864 chr5:267000 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.73 0.38 1.02e-10 Breast cancer; CESC cis rs8114671 0.562 rs3818273 chr20:33509275 G/A cg06115741 chr20:33292138 TP53INP2 0.48 5.79 0.34 1.97e-8 Height; CESC cis rs5753618 0.519 rs5997939 chr22:31677130 C/G cg13145458 chr22:31556086 RNF185 0.51 5.68 0.33 3.46e-8 Colorectal cancer; CESC cis rs9894429 0.789 rs35887231 chr17:79587126 G/A cg21984481 chr17:79567631 NPLOC4 -0.58 -9.48 -0.5 1.5e-18 Eye color traits; CESC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg19500275 chr17:80737654 TBCD 0.45 5.19 0.3 4.13e-7 Glycated hemoglobin levels; CESC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg22920501 chr2:26401640 FAM59B -0.68 -8.21 -0.45 9.56e-15 Gut microbiome composition (summer); CESC cis rs561341 0.609 rs7214626 chr17:30190989 G/A cg13647721 chr17:30228624 UTP6 -0.74 -8.56 -0.47 9.61e-16 Hip circumference adjusted for BMI; CESC cis rs5753618 0.561 rs9606830 chr22:31717799 T/G cg13145458 chr22:31556086 RNF185 -0.48 -5.37 -0.31 1.69e-7 Colorectal cancer; CESC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg05564831 chr3:52568323 NT5DC2 0.47 7.52 0.42 8.51e-13 Bipolar disorder; CESC cis rs8038465 0.967 rs3935942 chr15:73971361 C/A cg15420318 chr15:73925796 NPTN 0.44 6.26 0.36 1.52e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.6 0.38 2.18e-10 Bipolar disorder; CESC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12506373 chr2:27440548 CAD -0.45 -6.62 -0.38 1.94e-10 Gambling; CESC cis rs6460942 1.000 rs62448565 chr7:12400458 G/A cg13733410 chr7:12443478 VWDE -0.53 -5.23 -0.31 3.41e-7 Coronary artery disease; CESC cis rs9611565 0.592 rs8779 chr22:42070276 T/C cg03806693 chr22:41940476 POLR3H 1.09 12.68 0.61 4.09e-29 Vitiligo; CESC cis rs1348850 0.554 rs1374438 chr2:178376684 A/G cg23306229 chr2:178417860 TTC30B 0.81 7.5 0.42 9.42e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14172532 chr2:242447907 STK25 0.55 6.26 0.36 1.56e-9 Gut microbiome composition (summer); CESC cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg22823121 chr1:150693482 HORMAD1 -0.4 -6.27 -0.36 1.42e-9 Tonsillectomy; CESC cis rs11711311 1.000 rs2566963 chr3:113531849 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.57 -7.35 -0.41 2.41e-12 IgG glycosylation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18604876 chr3:5164258 ARL8B -0.46 -6.8 -0.39 6.73e-11 Fibrinogen levels; CESC cis rs6121246 0.567 rs6060249 chr20:30190944 G/A cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs2415984 0.520 rs60342772 chr14:46935394 C/A cg14871534 chr14:47121158 RPL10L 0.39 5.69 0.33 3.39e-8 Number of children ever born; CESC cis rs7107174 1.000 rs2512532 chr11:77968641 T/C cg02023728 chr11:77925099 USP35 0.45 6.35 0.36 9.37e-10 Testicular germ cell tumor; CESC trans rs3934047 0.869 rs8032149 chr15:82044488 C/G cg23228694 chr20:35089521 DLGAP4 -0.43 -6.01 -0.35 6.08e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs2625529 0.617 rs7175792 chr15:72431883 C/G cg16672083 chr15:72433130 SENP8 -0.45 -6.88 -0.39 4.23e-11 Red blood cell count; CESC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 6.08 0.35 4.09e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02628353 chr7:26241504 HNRNPA2B1;CBX3 -0.44 -6.21 -0.36 2.06e-9 Gambling; CESC cis rs709400 1.000 rs861539 chr14:104165753 G/A cg12935359 chr14:103987150 CKB -0.46 -6.22 -0.36 1.92e-9 Body mass index; CESC cis rs2243480 1.000 rs160643 chr7:65558222 C/T cg13147721 chr7:65941812 NA -0.81 -7.64 -0.42 3.97e-13 Diabetic kidney disease; CESC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg00166722 chr3:10149974 C3orf24 0.46 5.45 0.32 1.17e-7 Alzheimer's disease; CESC cis rs12995491 0.933 rs13023008 chr2:88530933 G/A cg14558114 chr2:88469736 THNSL2 -0.49 -7.1 -0.4 1.13e-11 Response to metformin (IC50); CESC cis rs7635838 0.892 rs6792718 chr3:11434380 A/G cg00170343 chr3:11313890 ATG7 0.43 5.61 0.33 5.16e-8 HDL cholesterol; CESC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.73 -0.38 1.06e-10 Intelligence (multi-trait analysis); CESC cis rs116095464 0.558 rs56127718 chr5:270273 G/T cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.45 0.32 1.14e-7 Breast cancer; CESC cis rs8112211 0.911 rs2286475 chr19:38847431 T/C cg14299480 chr19:38876666 GGN -0.44 -5.65 -0.33 4.19e-8 Blood protein levels; CESC trans rs1038304 0.742 rs10872676 chr6:151943977 C/T cg23736843 chr12:113541915 RASAL1 0.39 6.03 0.35 5.57e-9 Bone mineral density (spine);Bone mineral density (hip);Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg18099408 chr3:52552593 STAB1 -0.38 -6.46 -0.37 5.02e-10 Electroencephalogram traits; CESC cis rs703842 1.000 rs11172351 chr12:58213485 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.7 8.77 0.47 2.23e-16 Multiple sclerosis; CESC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg08859206 chr1:53392774 SCP2 -0.63 -8.33 -0.46 4.29e-15 Monocyte count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25377475 chr1:236030556 LYST 0.44 6.32 0.36 1.11e-9 Gut microbiota (bacterial taxa); CESC cis rs116095464 0.558 rs10043002 chr5:226753 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.64 0.33 4.4e-8 Breast cancer; CESC cis rs6674176 0.561 rs7161 chr1:44438974 A/G cg13606994 chr1:44402422 ARTN 0.42 6.6 0.38 2.27e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7264396 0.790 rs3787168 chr20:34233278 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.61 7.45 0.42 1.3e-12 Total cholesterol levels; CESC cis rs7666738 0.606 rs4637413 chr4:99088151 A/G cg17366294 chr4:99064904 C4orf37 0.43 5.77 0.33 2.15e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg17372223 chr3:52568218 NT5DC2 0.34 5.14 0.3 5.23e-7 Electroencephalogram traits; CESC cis rs1707322 0.758 rs10789474 chr1:46250040 G/T cg05343316 chr1:45956843 TESK2 0.47 5.7 0.33 3.21e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7246657 0.823 rs4802236 chr19:37919246 A/G cg23950597 chr19:37808831 NA -0.6 -6.18 -0.35 2.39e-9 Coronary artery calcification; CESC cis rs17376456 0.877 rs2085960 chr5:93399934 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.03 0.3 9.19e-7 Diabetic retinopathy; CESC cis rs9291683 0.632 rs13137074 chr4:10042842 C/T cg11266682 chr4:10021025 SLC2A9 0.67 13.02 0.62 2.72e-30 Bone mineral density; CESC cis rs4722166 0.630 rs2091115 chr7:22810166 G/T cg05472934 chr7:22766657 IL6 0.8 10.46 0.54 1.15e-21 Lung cancer; CESC trans rs561341 1.000 rs546748 chr17:30324293 A/C cg20587970 chr11:113659929 NA -0.85 -10.99 -0.56 2.11e-23 Hip circumference adjusted for BMI; CESC cis rs7542091 0.666 rs7537070 chr1:210043565 A/G cg22029157 chr1:209979665 IRF6 0.5 7.98 0.44 4.32e-14 Monobrow; CESC cis rs9894429 0.966 rs10871499 chr17:79589006 G/A cg13777783 chr17:79615861 NA -0.35 -5.76 -0.33 2.29e-8 Eye color traits; CESC cis rs7264396 0.563 rs59064961 chr20:34307950 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.75 0.38 9.35e-11 Total cholesterol levels; CESC cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg12292205 chr6:26970375 C6orf41 -0.53 -5.76 -0.33 2.33e-8 Intelligence (multi-trait analysis); CESC trans rs7839040 0.647 rs7824911 chr8:82929567 T/C cg14472086 chr9:107730925 NA -0.48 -6.33 -0.36 1.03e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs9929218 0.954 rs35444713 chr16:68824492 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -8.16 -0.45 1.33e-14 Colorectal cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17330983 chr14:23770641 PPP1R3E -0.42 -6.01 -0.35 6.06e-9 Gambling; CESC cis rs2108225 0.837 rs6958729 chr7:107451211 A/G cg18560240 chr7:107437656 SLC26A3 0.42 5.73 0.33 2.68e-8 Ulcerative colitis; CESC cis rs561341 1.000 rs56903735 chr17:30254393 T/A cg00745463 chr17:30367425 LRRC37B -0.7 -6.9 -0.39 3.75e-11 Hip circumference adjusted for BMI; CESC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg11301795 chr4:187892539 NA -0.81 -14.18 -0.66 2.37e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg09323728 chr8:95962352 TP53INP1 -0.41 -8.93 -0.48 7.13e-17 Type 2 diabetes; CESC cis rs2836633 0.929 rs62217517 chr21:40033177 T/A cg05519781 chr21:40033154 ERG 0.79 13.49 0.64 6.12e-32 Coronary artery disease; CESC cis rs16910800 0.731 rs16910738 chr11:23189455 C/T cg20040320 chr11:23191996 NA -0.67 -6.66 -0.38 1.53e-10 Cancer; CESC cis rs2832191 0.716 rs1984012 chr21:30392472 T/C cg08807101 chr21:30365312 RNF160 0.96 14.95 0.68 4.69e-37 Dental caries; CESC cis rs6460942 0.591 rs62448728 chr7:12332915 A/T cg20607287 chr7:12443886 VWDE -0.63 -6.83 -0.39 5.83e-11 Coronary artery disease; CESC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg16743903 chr16:89593216 SPG7 -0.42 -5.42 -0.32 1.36e-7 Multiple myeloma (IgH translocation); CESC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg25072359 chr17:41440525 NA 0.51 6.82 0.39 6.26e-11 Menopause (age at onset); CESC cis rs10751667 1.000 rs7395632 chr11:958789 C/T cg06064525 chr11:970664 AP2A2 0.36 6.55 0.37 3.01e-10 Alzheimer's disease (late onset); CESC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg20862496 chr8:143823734 SLURP1 0.33 5.2 0.3 4.05e-7 Urinary tract infection frequency; CESC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg25767906 chr1:53392781 SCP2 -0.57 -8.18 -0.45 1.22e-14 Monocyte count; CESC cis rs10276381 1.000 rs10260837 chr7:28181129 C/T cg23620719 chr7:28220237 JAZF1 0.7 7.22 0.41 5.61e-12 Crohn's disease; CESC trans rs2018683 0.707 rs10279610 chr7:28975696 C/G cg19402173 chr7:128379420 CALU 0.49 6.46 0.37 5.06e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs10779751 0.734 rs2748878 chr1:11129434 T/C cg08854313 chr1:11322531 MTOR 0.76 10.26 0.53 4.97e-21 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00322698 chr6:41069048 NFYA;LOC221442 0.52 7.29 0.41 3.58e-12 Fibrinogen levels; CESC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg03609598 chr5:56110824 MAP3K1 -0.49 -5.32 -0.31 2.16e-7 Initial pursuit acceleration; CESC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg18099408 chr3:52552593 STAB1 -0.31 -5.18 -0.3 4.4e-7 Bipolar disorder; CESC cis rs3106136 0.609 rs72665612 chr4:95101183 T/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.23 -0.36 1.8e-9 Capecitabine sensitivity; CESC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg11764359 chr7:65958608 NA -0.68 -8.81 -0.48 1.68e-16 Aortic root size; CESC cis rs2354432 0.607 rs59606861 chr1:146761478 G/A cg25205988 chr1:146714368 CHD1L -0.95 -8.2 -0.45 1.05e-14 Mitochondrial DNA levels; CESC cis rs6466055 0.666 rs4730081 chr7:105006850 C/T cg04380332 chr7:105027541 SRPK2 -0.41 -5.31 -0.31 2.38e-7 Schizophrenia; CESC cis rs7208859 0.623 rs56812022 chr17:29068733 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.48 0.37 4.4e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg18876405 chr7:65276391 NA -0.49 -6.75 -0.38 9.38e-11 Aortic root size; CESC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.51 -0.32 8.35e-8 Huntington's disease progression; CESC cis rs4835473 0.932 rs4516663 chr4:144901944 G/C cg25736465 chr4:144833511 NA 0.41 6.2 0.36 2.14e-9 Immature fraction of reticulocytes; CESC cis rs7659604 0.502 rs4315813 chr4:122674866 G/A cg19671926 chr4:122722719 EXOSC9 0.53 6.7 0.38 1.21e-10 Type 2 diabetes; CESC cis rs2797160 1.000 rs2797160 chr6:126010116 A/G cg05901451 chr6:126070800 HEY2 0.45 6.6 0.38 2.19e-10 Endometrial cancer; CESC trans rs7395662 0.553 rs4882155 chr11:48705801 T/C cg15704280 chr7:45808275 SEPT13 -0.51 -6.12 -0.35 3.31e-9 HDL cholesterol; CESC cis rs72781680 0.948 rs72796319 chr2:24133027 T/C cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs12586317 0.547 rs2383693 chr14:35500205 A/C cg16230307 chr14:35515116 FAM177A1 1.06 11.29 0.57 2.17e-24 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04282497 chr4:82350883 RASGEF1B -0.65 -7.27 -0.41 3.92e-12 Gut microbiome composition (summer); CESC cis rs6942756 0.774 rs891545 chr7:128866616 A/C cg02491457 chr7:128862824 NA 0.66 9.86 0.52 9.46e-20 White matter hyperintensity burden; CESC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.57 0.32 6.16e-8 Menopause (age at onset); CESC cis rs11642862 1.000 rs11645367 chr16:30770074 C/T cg02466173 chr16:30829666 NA -0.6 -6.07 -0.35 4.4e-9 Tonsillectomy; CESC cis rs9910055 0.529 rs2523161 chr17:42179405 C/T cg13607699 chr17:42295918 UBTF -0.56 -7.35 -0.41 2.47e-12 Total body bone mineral density; CESC cis rs11676348 0.808 rs4674267 chr2:219046437 C/T cg00012203 chr2:219082015 ARPC2 -0.4 -5.05 -0.3 8.09e-7 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00164301 chr17:80351457 C17orf101 -0.5 -6.1 -0.35 3.69e-9 Gut microbiome composition (summer); CESC cis rs977987 0.835 rs1010630 chr16:75328591 G/T cg03315344 chr16:75512273 CHST6 0.38 5.56 0.32 6.54e-8 Dupuytren's disease; CESC cis rs4474465 0.688 rs7945812 chr11:78280509 T/C cg27205649 chr11:78285834 NARS2 0.52 7.14 0.4 9.17e-12 Alzheimer's disease (survival time); CESC cis rs965469 0.779 rs6037543 chr20:3289505 A/G cg25506879 chr20:3388711 C20orf194 -0.48 -5.31 -0.31 2.36e-7 IFN-related cytopenia; CESC cis rs10779751 0.881 rs2744820 chr1:11365015 G/A cg08854313 chr1:11322531 MTOR -0.78 -11.0 -0.56 1.98e-23 Body mass index; CESC cis rs2730245 0.661 rs842696 chr7:158662698 T/C cg15303052 chr7:158526867 ESYT2 -0.4 -5.07 -0.3 7.39e-7 Height; CESC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg03709012 chr19:19516395 GATAD2A 0.99 15.45 0.69 7.85e-39 Tonsillectomy; CESC cis rs3785574 0.962 rs114027117 chr17:61939935 T/A cg11494091 chr17:61959527 GH2 0.36 5.08 0.3 7.19e-7 Height; CESC cis rs6545883 0.965 rs11887205 chr2:61774473 T/G cg15711740 chr2:61764176 XPO1 -0.44 -5.37 -0.31 1.7e-7 Tuberculosis; CESC cis rs7520050 0.966 rs61783200 chr1:46297403 T/C cg03146154 chr1:46216737 IPP -0.48 -6.3 -0.36 1.25e-9 Red blood cell count;Reticulocyte count; CESC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.89 0.52 7.53e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6060717 0.536 rs7271036 chr20:34467215 C/T cg23207816 chr20:34252616 CPNE1;RBM12 -0.66 -5.7 -0.33 3.16e-8 Hip circumference adjusted for BMI; CESC cis rs4253772 0.591 rs9615343 chr22:46690824 C/G cg24881330 chr22:46731750 TRMU 0.73 5.24 0.31 3.32e-7 LDL cholesterol;Cholesterol, total; CESC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC cis rs1797885 0.564 rs2596822 chr3:12596844 C/T cg26432171 chr3:12704882 RAF1 0.51 6.15 0.35 2.79e-9 Immature fraction of reticulocytes; CESC cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg01416388 chr22:39784598 NA -0.56 -6.99 -0.39 2.21e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs916888 0.738 rs199515 chr17:44856641 C/G cg01570182 chr17:44337453 NA -0.87 -10.82 -0.55 7.56e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs9467711 0.606 rs28362606 chr6:26365586 T/C cg06606381 chr12:133084897 FBRSL1 -0.76 -6.94 -0.39 3.06e-11 Autism spectrum disorder or schizophrenia; CESC cis rs34172651 0.571 rs9922156 chr16:24704329 C/A cg06028605 chr16:24865363 SLC5A11 -0.45 -6.75 -0.38 9.54e-11 Intelligence (multi-trait analysis); CESC cis rs12477438 0.520 rs11890338 chr2:99767868 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.46 0.69 7.45e-39 Chronic sinus infection; CESC cis rs35110281 0.807 rs4818850 chr21:45028071 T/G cg01579765 chr21:45077557 HSF2BP -0.59 -10.08 -0.53 1.87e-20 Mean corpuscular volume; CESC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg26875135 chr7:1221192 NA -0.43 -5.16 -0.3 4.89e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9549260 0.755 rs7338669 chr13:41200091 C/T cg21288729 chr13:41239152 FOXO1 -0.6 -7.78 -0.43 1.58e-13 Red blood cell count; CESC cis rs2637266 1.000 rs2395410 chr10:78381767 C/T cg18941641 chr10:78392320 NA 0.41 7.89 0.44 7.78e-14 Pulmonary function; CESC cis rs7927592 0.913 rs12283755 chr11:68371658 A/G cg20283391 chr11:68216788 NA -0.6 -7.17 -0.4 7.57e-12 Total body bone mineral density; CESC cis rs763014 0.898 rs916414 chr16:632073 C/T cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg11235426 chr6:292522 DUSP22 -0.71 -9.33 -0.5 4.49e-18 Menopause (age at onset); CESC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.16 0.4 7.99e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7188697 0.922 rs2243463 chr16:58571189 T/C cg21335942 chr16:58549945 SETD6 0.46 5.36 0.31 1.84e-7 QT interval; CESC trans rs4295623 0.559 rs4841600 chr8:11688148 T/C cg06636001 chr8:8085503 FLJ10661 0.52 6.49 0.37 4.28e-10 Morning vs. evening chronotype; CESC cis rs72720396 1.000 rs72720396 chr1:91191582 A/G cg13456504 chr1:91191583 NA 0.61 8.34 0.46 4.17e-15 Morning vs. evening chronotype;Chronotype; CESC cis rs73110464 0.609 rs11170348 chr12:53355588 A/G cg25025879 chr12:53359317 NA -0.61 -7.97 -0.44 4.59e-14 Cancer (pleiotropy); CESC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg21248554 chr2:27665150 KRTCAP3 -0.28 -6.05 -0.35 4.97e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs9549367 0.713 rs3024747 chr13:113821787 C/G cg00898013 chr13:113819073 PROZ -0.49 -6.96 -0.39 2.69e-11 Platelet distribution width; CESC cis rs763121 0.853 rs5757166 chr22:38995385 G/T cg06544989 chr22:39130855 UNC84B 0.51 9.34 0.5 4.01e-18 Menopause (age at onset); CESC cis rs228769 0.673 rs228787 chr17:42099488 C/T cg19774624 chr17:42201019 HDAC5 0.52 6.29 0.36 1.29e-9 Bone mineral density (hip);Bone mineral density (spine); CESC cis rs7980687 0.628 rs2102949 chr12:123676763 G/A cg00376283 chr12:123451042 ABCB9 0.67 9.28 0.5 6.47e-18 Height;Educational attainment;Head circumference (infant); CESC cis rs73019876 0.869 rs1849006 chr19:22142764 A/C cg11619707 chr19:22235551 ZNF257 -0.27 -5.12 -0.3 5.94e-7 Testicular germ cell tumor; CESC trans rs16893526 1.000 rs16893491 chr6:82496625 G/A cg22476893 chr17:7210162 EIF5A 0.78 6.06 0.35 4.53e-9 Coronary heart disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01487461 chr9:2017199 SMARCA2 -0.6 -6.49 -0.37 4.18e-10 Gut microbiome composition (summer); CESC cis rs62229266 0.804 rs998383 chr21:37445739 C/G cg08632701 chr21:37451849 NA -0.39 -5.35 -0.31 1.91e-7 Mitral valve prolapse; CESC cis rs2282802 0.685 rs6580473 chr5:139646962 C/T cg26211634 chr5:139558579 C5orf32 -0.5 -7.38 -0.41 2.02e-12 Intelligence (multi-trait analysis); CESC cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg03060546 chr3:49711283 APEH 0.45 5.5 0.32 9e-8 Parkinson's disease; CESC trans rs10776614 0.799 rs11101382 chr10:49766377 G/A cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs6460942 0.915 rs62448602 chr7:12457145 T/G cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs1707322 0.717 rs1135812 chr1:46095272 T/C cg05343316 chr1:45956843 TESK2 0.51 6.35 0.36 9.45e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1814175 0.817 rs11040651 chr11:49938395 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -20.27 -0.78 8.31e-56 Height; CESC cis rs55882075 0.690 rs12374485 chr5:179131395 G/C cg14593053 chr5:179126677 CANX 0.59 8.49 0.46 1.53e-15 Monocyte percentage of white cells; CESC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.853 rs4821809 chr22:39065743 G/C cg06022373 chr22:39101656 GTPBP1 0.88 13.81 0.65 4.88e-33 Menopause (age at onset); CESC cis rs2073300 1.000 rs6137982 chr20:23468892 T/A cg12062639 chr20:23401060 NAPB 0.92 5.89 0.34 1.18e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2425143 1.000 rs78421482 chr20:34376486 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.69 5.95 0.34 8.54e-9 Blood protein levels; CESC cis rs12711979 0.509 rs13021385 chr2:3826387 T/C cg17052675 chr2:3827356 NA -0.67 -11.05 -0.56 1.35e-23 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.56 0.42 6.72e-13 Prudent dietary pattern; CESC cis rs576982 1 rs576982 chr15:78870803 C/T cg24631222 chr15:78858424 CHRNA5 0.81 10.22 0.53 6.76e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs72781680 0.611 rs7596820 chr2:24335036 G/C cg20701182 chr2:24300061 SF3B14 0.91 10.51 0.54 7.88e-22 Lymphocyte counts; CESC cis rs11098499 0.697 rs10016448 chr4:120298845 A/G cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs2652822 0.550 rs72747098 chr15:63525249 G/A cg02713581 chr15:63449717 RPS27L 0.48 6.01 0.35 6.02e-9 Metabolic traits; CESC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.08e-8 Lung cancer; CESC cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg24110177 chr3:50126178 RBM5 0.54 7.46 0.42 1.25e-12 Body mass index; CESC cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg18402987 chr7:1209562 NA 0.59 7.08 0.4 1.33e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7078219 1.000 rs11190130 chr10:101275206 C/T cg09788492 chr10:101292477 NKX2-3 0.29 5.21 0.31 3.73e-7 Dental caries; CESC cis rs11696501 0.688 rs6124726 chr20:44307866 T/A cg11783356 chr20:44313418 WFDC10B -0.32 -5.12 -0.3 5.77e-7 Brain structure; CESC cis rs684232 0.800 rs371318 chr17:555816 A/G cg15660573 chr17:549704 VPS53 -0.42 -5.7 -0.33 3.13e-8 Prostate cancer; CESC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg23048001 chr7:2026167 MAD1L1 0.48 6.29 0.36 1.33e-9 Bipolar disorder and schizophrenia; CESC cis rs4925386 0.921 rs11204472 chr20:60920887 G/A cg24112000 chr20:60950667 NA 0.49 7.28 0.41 3.7e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs3857067 0.806 rs72665629 chr4:95112160 T/A cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Depression; CESC trans rs11098499 0.697 rs10016448 chr4:120298845 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs11969893 0.850 rs9390713 chr6:101424262 G/A cg12253828 chr6:101329408 ASCC3 0.95 6.16 0.35 2.68e-9 Economic and political preferences (immigration/crime); CESC cis rs61931739 0.534 rs11053131 chr12:34282109 A/G cg19457237 chr12:34500585 NA -0.36 -5.06 -0.3 7.97e-7 Morning vs. evening chronotype; CESC cis rs2072499 0.750 rs2241109 chr1:156173082 C/T cg24450063 chr1:156163899 SLC25A44 0.96 12.2 0.6 1.78e-27 Testicular germ cell tumor; CESC cis rs6967414 0.681 rs11979878 chr7:6753803 A/G cg09896999 chr7:6746977 ZNF12 -0.51 -6.29 -0.36 1.29e-9 Hematocrit;Hemoglobin concentration; CESC cis rs9868809 0.505 rs73080312 chr3:48737847 C/T cg00383909 chr3:49044727 WDR6 0.91 5.6 0.33 5.41e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs4971059 0.629 rs11264333 chr1:155108287 G/A cg22049894 chr1:155113146 DPM3 0.45 5.87 0.34 1.28e-8 Breast cancer; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04633058 chr17:48474099 LRRC59 -0.44 -6.19 -0.36 2.26e-9 Height; CESC cis rs6963495 0.818 rs6944787 chr7:105147309 C/T cg02135003 chr7:105160482 PUS7 -0.47 -5.61 -0.33 5.12e-8 Bipolar disorder (body mass index interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24769158 chr12:123351868 VPS37B 0.45 6.07 0.35 4.39e-9 Fibrinogen levels; CESC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.48 7.25 0.41 4.6e-12 Bipolar disorder; CESC cis rs9287719 0.967 rs6755548 chr2:10746126 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC cis rs7208859 0.524 rs59923796 chr17:29064919 G/A cg14008862 chr17:28927542 LRRC37B2 0.64 5.11 0.3 6.29e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9733 0.744 rs12125650 chr1:150760174 A/G cg18016565 chr1:150552671 MCL1 -0.36 -5.89 -0.34 1.19e-8 Tonsillectomy; CESC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg12379764 chr21:47803548 PCNT -0.53 -6.74 -0.38 1.01e-10 Testicular germ cell tumor; CESC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg26354017 chr1:205819088 PM20D1 0.84 13.67 0.64 1.51e-32 Menarche (age at onset); CESC cis rs9583531 0.574 rs7319459 chr13:111352408 T/C cg15841412 chr13:111365552 ING1 -0.49 -6.3 -0.36 1.2e-9 Coronary artery disease; CESC cis rs1348850 0.914 rs8941 chr2:178406481 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.87 12.42 0.61 3.15e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4900538 0.892 rs4906208 chr14:102956489 G/C cg18135206 chr14:102964638 TECPR2 0.84 11.44 0.58 6.53e-25 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs11532322 1 rs11532322 chr12:123731423 A/G cg00376283 chr12:123451042 ABCB9 0.67 8.89 0.48 9.54e-17 Schizophrenia; CESC cis rs796364 0.616 rs2689765 chr2:200696352 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.62 6.12 0.35 3.42e-9 Schizophrenia; CESC cis rs6540556 0.769 rs10157973 chr1:209924425 C/T cg05527609 chr1:210001259 C1orf107 -0.49 -5.89 -0.34 1.17e-8 Red blood cell count; CESC cis rs10782582 0.593 rs11578480 chr1:76208989 T/G cg10523679 chr1:76189770 ACADM -0.48 -5.57 -0.32 6.16e-8 Daytime sleep phenotypes; CESC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg05564831 chr3:52568323 NT5DC2 0.45 6.82 0.39 5.99e-11 Bipolar disorder; CESC cis rs1348850 0.914 rs7573763 chr2:178249808 C/T cg23306229 chr2:178417860 TTC30B 0.65 8.11 0.45 1.95e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg00585742 chr6:160219791 NA 0.4 6.03 0.35 5.35e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg05340658 chr4:99064831 C4orf37 0.77 11.88 0.59 2.27e-26 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 1.000 rs4813562 chr20:25352588 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.23e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs9303401 0.659 rs36093395 chr17:56957357 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.69 0.61 3.78e-29 Cognitive test performance; CESC cis rs1800795 0.652 rs7802307 chr7:22766433 T/A cg26061582 chr7:22766209 IL6 0.45 5.14 0.3 5.34e-7 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CESC cis rs12360000 0.770 rs12251959 chr10:1902277 C/T cg26364871 chr10:1889757 NA -0.4 -5.35 -0.31 1.88e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs920590 0.758 rs62496731 chr8:19659543 C/G cg17834443 chr8:19674713 INTS10 0.6 6.71 0.38 1.17e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs2180341 0.842 rs9375492 chr6:127545492 C/T cg24812749 chr6:127587940 RNF146 -0.99 -11.99 -0.59 9.5e-27 Breast cancer; CESC cis rs4237845 0.537 rs10747787 chr12:58260657 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.47 5.51 0.32 8.7e-8 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03376029 chr16:89133406 NA 0.32 6.06 0.35 4.53e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1506636 1.000 rs12333705 chr7:123356062 C/T cg03229431 chr7:123269106 ASB15 -0.52 -6.91 -0.39 3.58e-11 Plateletcrit;Platelet count; CESC trans rs6964833 1.000 rs4717907 chr7:74086493 C/T cg07504079 chr7:72649617 NCF1B -0.54 -6.21 -0.36 2.08e-9 Menarche (age at onset); CESC cis rs3015497 0.789 rs2934688 chr14:51112360 G/A cg09863266 chr14:51125203 SAV1 -0.34 -5.26 -0.31 3.04e-7 Mean platelet volume; CESC cis rs4843747 0.636 rs11864872 chr16:88105966 A/G cg06374794 chr16:88002281 BANP 0.39 5.15 0.3 5.02e-7 Menopause (age at onset); CESC cis rs9905704 0.627 rs6503867 chr17:56621359 T/C cg12560992 chr17:57184187 TRIM37 -0.64 -6.09 -0.35 4.06e-9 Testicular germ cell tumor; CESC cis rs2243480 1.000 rs313832 chr7:65550891 G/T cg18252515 chr7:66147081 NA -1.38 -13.59 -0.64 2.8099999999999997e-32 Diabetic kidney disease; CESC cis rs56235845 0.694 rs11738681 chr5:176761535 A/G cg06060754 chr5:176797920 RGS14 0.41 5.18 0.3 4.44e-7 Hemoglobin concentration;Hematocrit; CESC trans rs13063635 0.915 rs34338823 chr3:45928769 G/A cg10236987 chr1:228114221 WNT9A 0.63 6.49 0.37 4.17e-10 Eosinophil percentage of granulocytes; CESC cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg25566285 chr7:158114605 PTPRN2 0.5 8.17 0.45 1.27e-14 Calcium levels; CESC cis rs7264396 0.733 rs6058305 chr20:34310757 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.83 -0.59 3.3e-26 Total cholesterol levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14616479 chr3:155588124 GMPS -0.45 -6.52 -0.37 3.57e-10 Gambling; CESC cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs3815700 1.000 rs8104729 chr19:33093979 C/T cg02997394 chr19:33096574 ANKRD27 0.73 7.3 0.41 3.26e-12 Eosinophilic esophagitis; CESC cis rs864537 0.590 rs1214596 chr1:167427170 A/T cg09179987 chr1:167433047 CD247 -0.53 -7.97 -0.44 4.7e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg06873352 chr17:61820015 STRADA 0.72 12.79 0.62 1.65e-29 Prudent dietary pattern; CESC trans rs7752903 0.793 rs5029939 chr6:138195723 C/G cg02519892 chr21:43198586 NA -0.72 -6.2 -0.36 2.2e-9 Rheumatoid arthritis; CESC trans rs11098499 0.644 rs7693919 chr4:120540571 G/A cg25214090 chr10:38739885 LOC399744 0.63 8.87 0.48 1.14e-16 Corneal astigmatism; CESC cis rs6910061 1.000 rs6910061 chr6:11101918 A/T cg27233058 chr6:11094804 LOC221710 -0.46 -5.1 -0.3 6.35e-7 Diabetic kidney disease; CESC cis rs7084402 0.565 rs11006188 chr10:60333471 G/C cg07615347 chr10:60278583 BICC1 0.41 5.98 0.34 7.21e-9 Refractive error; CESC cis rs938554 0.692 rs6449213 chr4:9994215 A/G cg00071950 chr4:10020882 SLC2A9 -0.6 -6.72 -0.38 1.13e-10 Blood metabolite levels; CESC cis rs35146811 0.844 rs13223792 chr7:99675659 T/G cg22906224 chr7:99728672 NA 0.43 5.28 0.31 2.66e-7 Coronary artery disease; CESC cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg23711669 chr6:146136114 FBXO30 0.99 15.01 0.68 2.93e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs9902453 0.765 rs2628180 chr17:28101723 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg03146154 chr1:46216737 IPP -0.43 -5.35 -0.31 1.87e-7 High light scatter reticulocyte count; CESC trans rs916888 0.773 rs199439 chr17:44793503 A/G cg07870213 chr5:140052090 DND1 0.63 6.77 0.38 8.36e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs17666538 0.585 rs6559064 chr8:623061 G/A cg07234876 chr8:600039 NA 0.85 6.02 0.35 5.83e-9 IgG glycosylation; CESC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.93 9.74 0.51 2.3e-19 Platelet count; CESC cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11785400 0.793 rs7017851 chr8:143722038 G/T cg24634471 chr8:143751801 JRK 0.43 5.38 0.31 1.64e-7 Schizophrenia; CESC cis rs11630290 0.736 rs4777370 chr15:64160104 G/A cg12036633 chr15:63758958 NA 0.5 5.38 0.31 1.63e-7 Iris characteristics; CESC cis rs2625529 0.712 rs2054601 chr15:72184968 T/C cg16672083 chr15:72433130 SENP8 -0.39 -5.05 -0.3 8.1e-7 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19332102 chr11:124588484 NA -0.58 -6.94 -0.39 3.01e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg03467027 chr4:99064603 C4orf37 0.45 5.67 0.33 3.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs42648 1.000 rs42658 chr7:89981915 T/A cg23697855 chr7:89950296 NA 0.28 5.09 0.3 6.83e-7 Homocysteine levels; CESC cis rs3733585 0.699 rs4339211 chr4:9947658 C/T cg02734326 chr4:10020555 SLC2A9 -0.42 -5.91 -0.34 1.05e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs56309584 0.673 rs56256903 chr17:8123128 T/G cg06726167 chr17:8076949 TMEM107 -0.5 -5.1 -0.3 6.44e-7 Initial pursuit acceleration; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01452438 chr16:4303710 NA 0.45 6.0 0.35 6.47e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs763121 0.853 rs2072796 chr22:39064230 A/G cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.58e-7 Menopause (age at onset); CESC cis rs9302635 0.640 rs9933009 chr16:72190650 G/A cg16558253 chr16:72132732 DHX38 -0.41 -5.32 -0.31 2.17e-7 Blood protein levels; CESC trans rs11098499 0.954 rs56270433 chr4:120406030 C/T cg25214090 chr10:38739885 LOC399744 0.72 10.18 0.53 9.16e-21 Corneal astigmatism; CESC cis rs7680126 0.633 rs2024280 chr4:10291813 A/G cg00071950 chr4:10020882 SLC2A9 -0.49 -5.04 -0.3 8.78e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs8048576 0.512 rs8063863 chr16:84400850 C/T cg03548384 chr16:84403863 ATP2C2 -0.4 -5.05 -0.3 8.39e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6988985 0.560 rs3753122 chr8:143926927 G/T cg10324643 chr8:143916377 GML 0.34 5.12 0.3 5.95e-7 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CESC cis rs34734847 0.933 rs998727 chr12:121149064 T/G cg21892295 chr12:121157589 UNC119B -0.4 -6.31 -0.36 1.16e-9 Mean corpuscular volume; CESC cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg02551604 chr5:131831745 NA 0.38 5.42 0.32 1.31e-7 Asthma (sex interaction); CESC cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg23422044 chr7:1970798 MAD1L1 -0.49 -5.34 -0.31 1.95e-7 Bipolar disorder; CESC cis rs524281 0.814 rs10896093 chr11:65958411 C/G cg14036092 chr11:66035641 RAB1B -0.59 -6.26 -0.36 1.54e-9 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15734422 chr10:121356865 TIAL1 0.62 7.05 0.4 1.52e-11 Gut microbiome composition (summer); CESC cis rs7116495 0.609 rs2735787 chr11:71717873 T/C cg10381502 chr11:71823885 C11orf51 -1.13 -7.53 -0.42 7.8e-13 Severe influenza A (H1N1) infection; CESC cis rs1348850 0.526 rs9288003 chr2:178446572 T/G cg23306229 chr2:178417860 TTC30B 0.57 5.57 0.32 6.21e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg18099408 chr3:52552593 STAB1 -0.33 -5.49 -0.32 9.3e-8 Bipolar disorder; CESC cis rs1018836 0.637 rs7843684 chr8:91470035 G/C cg16814680 chr8:91681699 NA -0.52 -7.17 -0.4 7.6e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg19774624 chr17:42201019 HDAC5 -0.82 -12.61 -0.61 7.15e-29 Total body bone mineral density; CESC cis rs3008870 0.755 rs3736905 chr1:67392614 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.64 8.39 0.46 2.87e-15 Lymphocyte percentage of white cells; CESC cis rs9486719 0.948 rs11153059 chr6:97014537 T/A cg06623918 chr6:96969491 KIAA0776 -0.8 -8.3 -0.45 5.39e-15 Migraine;Coronary artery disease; CESC cis rs524281 0.861 rs7120326 chr11:65849256 C/T cg14036092 chr11:66035641 RAB1B -0.57 -5.78 -0.33 2.06e-8 Electroencephalogram traits; CESC cis rs6460942 0.915 rs62448598 chr7:12453762 T/C cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01693652 chr20:60961553 RPS21 0.45 6.44 0.37 5.45e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs36051895 0.695 rs2183137 chr9:5026293 A/G cg02405213 chr9:5042618 JAK2 -0.51 -6.11 -0.35 3.52e-9 Pediatric autoimmune diseases; CESC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg18032046 chr6:28092343 ZSCAN16 -0.48 -6.22 -0.36 1.92e-9 Cardiac Troponin-T levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00828305 chr2:178077190 HNRNPA3 -0.49 -6.26 -0.36 1.51e-9 Ulcerative colitis; CESC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg02353165 chr6:42928485 GNMT 0.86 14.33 0.66 7.06e-35 Alzheimer's disease in APOE e4+ carriers; CESC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg02428538 chr16:24856791 SLC5A11 -0.61 -6.14 -0.35 2.98e-9 Intelligence (multi-trait analysis); CESC cis rs2456568 0.548 rs1607402 chr11:93660732 T/G cg26875233 chr11:93583750 C11orf90 -0.32 -5.55 -0.32 7.1e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.43 -5.41 -0.32 1.42e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4555082 0.874 rs56263609 chr14:105756944 C/T cg06808227 chr14:105710500 BRF1 -0.5 -5.34 -0.31 1.99e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7666738 0.830 rs13122456 chr4:98936011 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 0.730 rs9459841 chr6:167431949 G/A cg07741184 chr6:167504864 NA 0.36 6.56 0.37 2.77e-10 Crohn's disease; CESC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg08736216 chr1:53307985 ZYG11A 0.43 7.24 0.41 4.86e-12 Monocyte count; CESC cis rs12142240 0.698 rs112089006 chr1:46812360 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.85 0.43 1.05e-13 Menopause (age at onset); CESC cis rs34779708 0.931 rs7920095 chr10:35303334 G/A cg03585969 chr10:35415529 CREM 0.76 10.03 0.52 2.79e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16200569 chr12:56436204 RPS26 0.46 6.01 0.35 6.11e-9 Gut microbiota (bacterial taxa); CESC cis rs4820539 1.000 rs4822361 chr22:23482718 A/G cg14186256 chr22:23484241 RTDR1 -0.81 -15.04 -0.68 2.29e-37 Bone mineral density; CESC cis rs662064 0.925 rs669701 chr1:10544725 A/G cg20482658 chr1:10539492 PEX14 -0.39 -7.88 -0.44 8.7e-14 Asthma; CESC trans rs116095464 0.558 rs61492827 chr5:225774 A/G cg00938859 chr5:1591904 SDHAP3 0.61 6.78 0.38 7.58e-11 Breast cancer; CESC cis rs7216064 1.000 rs6504542 chr17:65836642 T/C cg12091567 chr17:66097778 LOC651250 -0.8 -9.08 -0.49 2.62e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg23711669 chr6:146136114 FBXO30 1.03 15.8 0.7 4.47e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg24549020 chr5:56110836 MAP3K1 -0.47 -5.68 -0.33 3.5e-8 Initial pursuit acceleration; CESC cis rs6987853 0.787 rs2923448 chr8:42406008 G/A cg09913449 chr8:42400586 C8orf40 0.45 7.6 0.42 5.18e-13 Mean corpuscular hemoglobin concentration; CESC cis rs9859260 0.744 rs419059 chr3:195782184 C/T cg12923728 chr3:195709715 SDHAP1 0.53 6.93 0.39 3.14e-11 Mean corpuscular volume; CESC cis rs4141404 0.851 rs5749222 chr22:31556759 C/G cg13145458 chr22:31556086 RNF185 0.53 6.39 0.37 7.43e-10 Paclitaxel-induced neuropathy; CESC cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg26597838 chr10:835615 NA 0.91 9.48 0.5 1.56e-18 Eosinophil percentage of granulocytes; CESC cis rs7236492 0.748 rs7228738 chr18:77231307 C/T cg15644404 chr18:77186268 NFATC1 -0.68 -5.18 -0.3 4.45e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs2857078 0.720 rs9906669 chr17:42305706 A/G cg08499158 chr17:42289980 UBTF -0.41 -5.1 -0.3 6.39e-7 Red cell distribution width;Reticulocyte count; CESC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg11766577 chr21:47581405 C21orf56 0.46 6.35 0.36 9.38e-10 Testicular germ cell tumor; CESC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg06636001 chr8:8085503 FLJ10661 0.45 5.92 0.34 9.72e-9 Mood instability; CESC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg12311346 chr5:56204834 C5orf35 -0.45 -5.46 -0.32 1.09e-7 Coronary artery disease; CESC trans rs1941023 0.672 rs2155710 chr11:60269240 C/T cg14715327 chr11:55109885 OR4A16 0.48 5.99 0.35 6.7e-9 Congenital heart disease (maternal effect); CESC cis rs3780486 1.000 rs12342831 chr9:33124872 A/G cg13443165 chr9:33130375 B4GALT1 0.42 5.56 0.32 6.46e-8 IgG glycosylation; CESC cis rs6444746 1.000 rs904881 chr3:193506621 G/T cg22553634 chr3:193489233 NA -0.41 -5.04 -0.3 8.64e-7 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); CESC cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg04414720 chr1:150670196 GOLPH3L -0.37 -5.19 -0.3 4.14e-7 Tonsillectomy; CESC trans rs1373453 0.808 rs78212762 chr12:70080191 G/A cg19702771 chr4:82058885 PRKG2 0.76 6.07 0.35 4.35e-9 Orofacial clefts; CESC cis rs2736345 0.535 rs4366049 chr8:11398504 A/G cg09528494 chr8:11338675 NA 0.31 5.78 0.33 2.15e-8 Sjögren's syndrome;Systemic lupus erythematosus; CESC cis rs939574 0.656 rs113370390 chr2:220132837 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.82 6.1 0.35 3.64e-9 Platelet distribution width; CESC cis rs6690583 0.623 rs7522239 chr1:85484366 C/T cg11262906 chr1:85462892 MCOLN2 0.52 5.08 0.3 7.03e-7 Serum sulfate level; CESC cis rs2832191 1.000 rs2832184 chr21:30483265 C/T cg24692254 chr21:30365293 RNF160 -0.74 -11.15 -0.57 6.22e-24 Dental caries; CESC trans rs2840044 0.554 rs225267 chr17:33964228 T/C cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Response to radiotherapy in cancer (late toxicity); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08826281 chr19:49655176 HRC 0.6 7.08 0.4 1.31e-11 Gut microbiome composition (summer); CESC cis rs10838687 0.736 rs4647754 chr11:47257340 C/T cg25783544 chr11:47291846 MADD 0.55 6.32 0.36 1.09e-9 Proinsulin levels; CESC cis rs10992471 0.702 rs10820967 chr9:95101729 C/G cg13798575 chr9:95087839 CENPP;NOL8 -0.46 -5.74 -0.33 2.57e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg01516881 chr6:292596 DUSP22 -0.52 -6.78 -0.38 7.86e-11 Menopause (age at onset); CESC cis rs2408955 0.522 rs973398 chr12:48491048 A/G cg04545296 chr12:48745243 ZNF641 -0.35 -6.11 -0.35 3.47e-9 Glycated hemoglobin levels; CESC cis rs7949030 0.504 rs2516633 chr11:62371773 A/C cg11742103 chr11:62369870 EML3;MTA2 -0.51 -7.29 -0.41 3.52e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg25036284 chr2:26402008 FAM59B 0.86 9.4 0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs17376456 0.877 rs10076052 chr5:93317762 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.33 0.31 2.15e-7 Diabetic retinopathy; CESC cis rs55871839 0.684 rs6988143 chr8:59810572 C/T cg07426533 chr8:59803705 TOX -0.47 -7.01 -0.4 1.95e-11 Pneumonia; CESC cis rs6963495 0.818 rs6973263 chr7:105170293 A/G cg19920283 chr7:105172520 RINT1 0.69 6.54 0.37 3.15e-10 Bipolar disorder (body mass index interaction); CESC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg17376030 chr22:41985996 PMM1 0.78 8.32 0.46 4.56e-15 Vitiligo; CESC cis rs6908843 0.532 rs79555858 chr6:166666497 G/A cg06878426 chr6:166666287 NA 0.46 5.36 0.31 1.8e-7 Macrophage inflammatory protein 1b levels; CESC cis rs9911578 0.967 rs2429369 chr17:56501420 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.26 0.31 2.93e-7 Intelligence (multi-trait analysis); CESC cis rs7267979 0.565 rs6107059 chr20:25592431 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -11.57 -0.58 2.56e-25 Liver enzyme levels (alkaline phosphatase); CESC cis rs12410462 0.681 rs113984727 chr1:227553917 C/A cg04117972 chr1:227635322 NA 0.67 5.8 0.34 1.92e-8 Major depressive disorder; CESC cis rs6570726 0.935 rs400968 chr6:145819718 A/G cg05347473 chr6:146136440 FBXO30 0.42 5.72 0.33 2.93e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs950776 0.714 rs472054 chr15:78887994 A/G cg06917634 chr15:78832804 PSMA4 -0.52 -6.21 -0.36 2.09e-9 Sudden cardiac arrest; CESC cis rs7647973 1.000 rs7644148 chr3:49545241 G/A cg06212747 chr3:49208901 KLHDC8B -0.59 -7.8 -0.43 1.43e-13 Menarche (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26570804 chr1:6352357 ACOT7 0.48 6.67 0.38 1.47e-10 Fibrinogen levels; CESC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg03806693 chr22:41940476 POLR3H -1.14 -13.06 -0.63 1.98e-30 Vitiligo; CESC cis rs7208859 0.673 rs11651802 chr17:29159660 T/C cg19761014 chr17:28927070 LRRC37B2 0.72 5.68 0.33 3.48e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.69 -0.33 3.41e-8 Depression; CESC cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.12 0.3 5.85e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7089973 0.934 rs68085797 chr10:116632130 A/T cg23260525 chr10:116636907 FAM160B1 0.37 5.89 0.34 1.16e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs543686 0.770 rs4923765 chr15:35052405 A/G cg05596267 chr15:34331198 CHRM5;AVEN -0.34 -5.11 -0.3 6.15e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs3796352 1.000 rs2564926 chr3:53094730 G/A cg12962167 chr3:53033115 SFMBT1 -0.61 -5.7 -0.33 3.19e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs6582630 0.537 rs8189533 chr12:38391068 A/G cg26384229 chr12:38710491 ALG10B 0.74 10.56 0.54 5.68e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs962856 0.619 rs6546297 chr2:67580520 G/T cg09028215 chr2:67624308 ETAA1 -0.44 -5.24 -0.31 3.29e-7 Pancreatic cancer; CESC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg20151795 chr6:28129481 ZNF389 0.42 5.43 0.32 1.28e-7 Parkinson's disease; CESC cis rs904092 0.720 rs1230025 chr4:100186376 A/T cg12011299 chr4:100065546 ADH4 0.52 6.09 0.35 3.95e-9 Alcohol dependence; CESC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.68 -0.58 1.06e-25 Alzheimer's disease; CESC cis rs2797160 1.000 rs1739374 chr6:126011825 C/T cg05901451 chr6:126070800 HEY2 0.46 6.63 0.38 1.87e-10 Endometrial cancer; CESC cis rs2637266 0.703 rs7084374 chr10:78479940 C/T cg18941641 chr10:78392320 NA 0.39 7.28 0.41 3.82e-12 Pulmonary function; CESC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs116095464 0.614 rs10059220 chr5:242813 C/T cg22857025 chr5:266934 NA -1.26 -13.65 -0.64 1.67e-32 Breast cancer; CESC cis rs8077577 0.945 rs997315 chr17:18085286 A/G cg16794390 chr17:18148240 FLII 0.42 5.6 0.33 5.42e-8 Obesity-related traits; CESC cis rs9457247 1.000 rs365189 chr6:167384545 G/A cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.27e-8 Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05341670 chr1:54518153 TMEM59;C1orf83 0.49 6.84 0.39 5.31e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1670533 1.000 rs10902752 chr4:1056199 C/T cg27284194 chr4:1044797 NA 0.48 6.06 0.35 4.7e-9 Recombination rate (females); CESC trans rs7726839 0.507 rs72703100 chr5:614291 C/T cg25482853 chr8:67687455 SGK3 1.02 9.93 0.52 5.72e-20 Obesity-related traits; CESC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.52 0.32 7.95e-8 Bipolar disorder; CESC cis rs7799006 0.582 rs7781284 chr7:2339405 G/T cg08027265 chr7:2291960 NA -0.47 -7.96 -0.44 4.92e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.35 0.31 1.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4835473 0.639 rs5029916 chr4:144911837 G/A cg25736465 chr4:144833511 NA 0.43 6.5 0.37 3.87e-10 Immature fraction of reticulocytes; CESC cis rs3126085 1.000 rs12567463 chr1:152180128 T/A cg26876637 chr1:152193138 HRNR -0.45 -5.09 -0.3 6.95e-7 Atopic dermatitis; CESC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg04369109 chr6:150039330 LATS1 -0.46 -6.57 -0.37 2.65e-10 Lung cancer; CESC cis rs7086627 0.515 rs10887899 chr10:82210214 G/A cg03267442 chr10:82210566 NA -0.33 -5.38 -0.31 1.67e-7 Post bronchodilator FEV1; CESC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg19468946 chr17:37922297 IKZF3 0.4 5.15 0.3 5.12e-7 Glomerular filtration rate (creatinine); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22638185 chr17:42385946 RUNDC3A 0.46 6.12 0.35 3.42e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7660520 0.524 rs4862101 chr4:183733177 T/C cg09197432 chr4:183729176 NA 0.58 5.63 0.33 4.56e-8 Pediatric autoimmune diseases; CESC cis rs7020830 0.931 rs9775431 chr9:37130433 G/A cg14294708 chr9:37120828 ZCCHC7 1.13 21.18 0.79 6.25e-59 Schizophrenia; CESC cis rs6599388 0.803 rs11248057 chr4:906131 C/G cg20814179 chr4:940893 TMEM175 -0.41 -5.39 -0.31 1.58e-7 Parkinson's disease; CESC cis rs853679 0.599 rs149943 chr6:28002388 G/A cg18032046 chr6:28092343 ZSCAN16 -0.7 -5.6 -0.33 5.38e-8 Depression; CESC cis rs559928 0.597 rs2186572 chr11:63895887 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 5.74 0.33 2.56e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs1624802 1.000 rs1707934 chr12:130497611 C/T cg15444478 chr12:130494697 NA 0.27 5.39 0.31 1.52e-7 Obesity-related traits; CESC cis rs4604732 0.642 rs7515859 chr1:247640057 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.38 0.31 1.63e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs644799 1.000 rs487609 chr11:95588102 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 13.4 0.64 1.26e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs763121 0.853 rs2281021 chr22:39064667 T/C cg14440974 chr22:39074834 NA -0.42 -5.82 -0.34 1.69e-8 Menopause (age at onset); CESC cis rs72781680 0.644 rs72783627 chr2:24315685 A/C cg20701182 chr2:24300061 SF3B14 0.92 10.55 0.54 6.09e-22 Lymphocyte counts; CESC cis rs12220238 1.000 rs2395077 chr10:75932001 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.02 0.35 5.83e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs710216 0.797 rs1770811 chr1:43400547 A/T cg03128534 chr1:43423976 SLC2A1 0.44 5.13 0.3 5.62e-7 Red cell distribution width; CESC cis rs6502050 0.769 rs8068708 chr17:80120424 T/C cg23985595 chr17:80112537 CCDC57 -0.4 -6.17 -0.35 2.56e-9 Life satisfaction; CESC cis rs854765 0.583 rs66531105 chr17:17809001 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.25 0.41 4.49e-12 Total body bone mineral density; CESC cis rs1707322 1.000 rs785519 chr1:46568562 C/T cg03146154 chr1:46216737 IPP -0.69 -9.13 -0.49 1.84e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8002861 0.846 rs56408817 chr13:44471983 A/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.47 -5.91 -0.34 1.06e-8 Leprosy; CESC cis rs654950 0.934 rs641974 chr1:42002137 G/A cg06885757 chr1:42089581 HIVEP3 -0.64 -10.35 -0.54 2.65e-21 Airway imaging phenotypes; CESC cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg03433033 chr1:76189801 ACADM 0.73 10.16 0.53 1.07e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2404602 0.692 rs12910734 chr15:77149931 A/G cg26408565 chr15:76604113 ETFA -0.39 -5.63 -0.33 4.54e-8 Blood metabolite levels; CESC cis rs6499129 1.000 rs9922624 chr16:67478976 C/T cg26727032 chr16:67993705 SLC12A4 -0.54 -5.7 -0.33 3.13e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg05340658 chr4:99064831 C4orf37 0.59 7.9 0.44 7.64e-14 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg02297831 chr4:17616191 MED28 0.56 7.03 0.4 1.78e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg17971929 chr21:40555470 PSMG1 -0.87 -12.28 -0.6 9.93e-28 Cognitive function; CESC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg06028605 chr16:24865363 SLC5A11 0.57 7.97 0.44 4.76e-14 Intelligence (multi-trait analysis); CESC cis rs478304 0.654 rs1074155 chr11:65458197 C/T cg27068330 chr11:65405492 SIPA1 0.43 5.28 0.31 2.68e-7 Acne (severe); CESC cis rs7703051 0.829 rs4704219 chr5:74748505 C/T cg03227963 chr5:74354835 NA 0.29 5.3 0.31 2.44e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg24110177 chr3:50126178 RBM5 -0.54 -7.45 -0.42 1.33e-12 Intelligence (multi-trait analysis); CESC cis rs6580649 0.941 rs72644847 chr12:48516093 C/A cg05342945 chr12:48394962 COL2A1 0.58 6.39 0.37 7.35e-10 Lung cancer; CESC cis rs4803468 1.000 rs2304242 chr19:41944616 G/T cg09537434 chr19:41945824 ATP5SL 1.13 21.82 0.8 4.09e-61 Height; CESC cis rs4319547 0.662 rs35417323 chr12:123090572 G/T cg05707623 chr12:122985044 ZCCHC8 -0.42 -5.12 -0.3 5.85e-7 Body mass index; CESC cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg23711669 chr6:146136114 FBXO30 -1.02 -15.75 -0.7 6.82e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs8077889 0.917 rs28694735 chr17:41912144 A/G cg26893861 chr17:41843967 DUSP3 0.74 9.32 0.5 4.61e-18 Triglycerides; CESC cis rs9287719 0.967 rs7566875 chr2:10754792 T/C cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs2380220 0.606 rs7747776 chr6:96005852 C/T cg04719120 chr6:96025338 MANEA 0.46 5.46 0.32 1.12e-7 Behavioural disinhibition (generation interaction); CESC cis rs7917772 0.503 rs7915589 chr10:104299264 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.76 -0.33 2.3e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.34 0.81 6.93e-63 Prudent dietary pattern; CESC cis rs7703051 0.634 rs6892023 chr5:74611574 G/T cg03227963 chr5:74354835 NA 0.28 5.1 0.3 6.5e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs9902453 0.845 rs72823935 chr17:28008595 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.77 0.47 2.21e-16 Coffee consumption (cups per day); CESC cis rs644799 0.562 rs1254989 chr11:95508121 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.52 7.1 0.4 1.16e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg24733560 chr20:60626293 TAF4 0.35 5.09 0.3 6.75e-7 Body mass index; CESC cis rs2070488 0.775 rs6599208 chr3:38558104 A/C cg24069376 chr3:38537580 EXOG -0.34 -5.89 -0.34 1.18e-8 Electrocardiographic conduction measures; CESC cis rs2204008 0.837 rs2892296 chr12:37969785 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.05 -0.44 2.74e-14 Bladder cancer; CESC trans rs35110281 0.776 rs62226866 chr21:45024186 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 7.28 0.41 3.82e-12 Mean corpuscular volume; CESC cis rs11031096 0.678 rs10767872 chr11:4184239 T/G cg18678763 chr11:4115507 RRM1 -0.43 -5.84 -0.34 1.53e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs1728785 1.000 rs1170431 chr16:68605639 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.93 0.44 6e-14 Ulcerative colitis; CESC cis rs561341 1.000 rs55962687 chr17:30260369 C/T cg00745463 chr17:30367425 LRRC37B -0.76 -6.96 -0.39 2.69e-11 Hip circumference adjusted for BMI; CESC cis rs9611565 0.512 rs139572 chr22:42214532 C/T cg06634786 chr22:41940651 POLR3H -0.55 -5.21 -0.3 3.87e-7 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14375786 chr9:139757366 EDF1 0.46 6.2 0.36 2.21e-9 Fibrinogen levels; CESC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg12463550 chr7:65579703 CRCP -0.46 -5.86 -0.34 1.34e-8 Aortic root size; CESC cis rs34779708 0.706 rs36027395 chr10:35550323 T/A cg03585969 chr10:35415529 CREM 0.55 6.25 0.36 1.61e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs6831352 0.918 rs17218162 chr4:100056060 G/A cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs2274273 0.905 rs10134800 chr14:55635209 A/G cg04306507 chr14:55594613 LGALS3 0.3 5.97 0.34 7.51e-9 Protein biomarker; CESC cis rs7927771 0.524 rs7116346 chr11:47883880 G/A cg20307385 chr11:47447363 PSMC3 -0.58 -8.11 -0.45 1.88e-14 Subjective well-being; CESC cis rs71403859 0.803 rs34381861 chr16:71640230 T/C cg08717414 chr16:71523259 ZNF19 -0.79 -6.93 -0.39 3.19e-11 Post bronchodilator FEV1; CESC cis rs7598759 0.675 rs6727530 chr2:232332058 T/C cg19187155 chr2:232395269 NMUR1 0.39 6.12 0.35 3.36e-9 Noise-induced hearing loss; CESC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.87 8.78 0.47 2.07e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7264396 0.943 rs224431 chr20:34153599 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.04 -0.35 5.27e-9 Total cholesterol levels; CESC cis rs7824557 0.579 rs10098322 chr8:11196295 C/G cg21775007 chr8:11205619 TDH 0.56 8.89 0.48 9.82e-17 Retinal vascular caliber; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07845895 chr21:34776100 IFNGR2 0.46 6.13 0.35 3.24e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs62432291 0.681 rs433786 chr6:159665946 T/A cg14500486 chr6:159655392 FNDC1 -0.65 -6.12 -0.35 3.27e-9 Joint mobility (Beighton score); CESC cis rs11958404 0.860 rs7730844 chr5:157461208 C/T cg05962755 chr5:157440814 NA 0.62 7.2 0.4 6.04e-12 IgG glycosylation; CESC cis rs2549003 0.933 rs7719499 chr5:131814091 C/G cg00255919 chr5:131827918 IRF1 0.51 8.25 0.45 7.38e-15 Asthma (sex interaction); CESC cis rs75804782 0.641 rs72987327 chr2:239359833 T/G cg18131467 chr2:239335373 ASB1 -0.7 -5.89 -0.34 1.18e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs7951870 0.645 rs2070852 chr11:46744925 C/G cg25783544 chr11:47291846 MADD -0.41 -5.18 -0.3 4.39e-7 Schizophrenia; CESC cis rs7044106 0.708 rs10984992 chr9:123473416 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.12 0.53 1.48e-20 Hip circumference adjusted for BMI; CESC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.76 -0.33 2.34e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9929218 0.529 rs35854485 chr16:68730855 C/G cg01251360 chr16:68772225 CDH1 -0.22 -5.05 -0.3 8.24e-7 Colorectal cancer; CESC cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg22875332 chr1:76189707 ACADM 0.67 7.99 0.44 4.13e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2073300 0.609 rs2277765 chr20:23425163 C/T cg12062639 chr20:23401060 NAPB 1.09 8.31 0.45 5.13e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9354308 0.901 rs2814121 chr6:66566915 G/C cg07460842 chr6:66804631 NA 0.68 7.68 0.43 3.08e-13 Metabolite levels; CESC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg02034447 chr16:89574710 SPG7 0.45 5.65 0.33 4.17e-8 Multiple myeloma (IgH translocation); CESC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg26818010 chr10:134567672 INPP5A -0.94 -11.42 -0.57 7.62e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg11890956 chr21:40555474 PSMG1 1.04 16.54 0.71 1.1e-42 Cognitive function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18415483 chr3:3221365 CRBN -0.51 -6.9 -0.39 3.72e-11 Fibrinogen levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07448460 chr8:63951879 GGH -0.42 -6.25 -0.36 1.67e-9 Gambling; CESC cis rs11098499 0.618 rs28491261 chr4:120294900 C/A cg24375607 chr4:120327624 NA 0.44 5.22 0.31 3.66e-7 Corneal astigmatism; CESC cis rs9902453 0.935 rs4310926 chr17:28433275 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.62 0.47 5.99e-16 Coffee consumption (cups per day); CESC cis rs9399135 0.967 rs9389258 chr6:135361140 T/C cg24558204 chr6:135376177 HBS1L 0.52 7.14 0.4 9.2e-12 Red blood cell count; CESC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg10074409 chr1:209979377 IRF6 0.39 5.12 0.3 5.88e-7 Cleft lip with or without cleft palate; CESC cis rs1943345 0.830 rs571055 chr11:82898829 G/C cg07047830 chr11:82868014 PCF11 0.55 6.17 0.35 2.57e-9 Obesity-related traits; CESC cis rs1215050 0.740 rs185468 chr4:98756242 C/T cg05340658 chr4:99064831 C4orf37 0.51 6.66 0.38 1.61e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs941873 0.868 rs2181080 chr10:81121960 A/G cg11057378 chr10:81107060 PPIF 0.36 5.69 0.33 3.29e-8 Height; CESC cis rs2688608 0.592 rs7908825 chr10:75554541 C/G cg23231163 chr10:75533350 FUT11 0.35 5.36 0.31 1.81e-7 Inflammatory bowel disease; CESC cis rs765787 0.530 rs3759892 chr15:45542709 A/G cg24006582 chr15:45444508 DUOX1 0.57 6.84 0.39 5.6e-11 Uric acid levels; CESC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.64 0.55 2.93e-22 Height; CESC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg05564831 chr3:52568323 NT5DC2 0.46 6.93 0.39 3.11e-11 Bipolar disorder; CESC cis rs17209837 0.607 rs4148813 chr7:87092376 A/G cg00919237 chr7:87102261 ABCB4 -0.49 -6.39 -0.37 7.37e-10 Gallbladder cancer; CESC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg09699651 chr6:150184138 LRP11 0.4 5.24 0.31 3.29e-7 Lung cancer; CESC cis rs12477438 1.000 rs995617 chr2:99857904 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.65 7.63 0.42 4.13e-13 Chronic sinus infection; CESC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg25072359 chr17:41440525 NA 0.43 5.83 0.34 1.61e-8 Menopause (age at onset); CESC cis rs10782582 0.593 rs17848068 chr1:76190216 G/A cg22875332 chr1:76189707 ACADM -0.45 -5.49 -0.32 9.26e-8 Daytime sleep phenotypes; CESC cis rs9733 0.596 rs12089989 chr1:150715782 G/A cg22823121 chr1:150693482 HORMAD1 0.42 6.3 0.36 1.26e-9 Tonsillectomy; CESC cis rs1801251 0.963 rs13021246 chr2:233623111 T/C cg25237894 chr2:233734115 C2orf82 0.45 7.9 0.44 7.6e-14 Coronary artery disease; CESC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.27 -0.31 2.89e-7 Aortic root size; CESC cis rs7615952 0.515 rs7630575 chr3:125682330 A/G cg05084668 chr3:125655381 ALG1L -0.49 -5.58 -0.32 5.99e-8 Blood pressure (smoking interaction); CESC cis rs10788264 0.652 rs9633732 chr10:124056473 G/T cg09507567 chr10:124027408 NA 0.39 5.82 0.34 1.71e-8 Total body bone mineral density; CESC trans rs2727020 0.538 rs61885230 chr11:49128958 T/C cg03929089 chr4:120376271 NA -0.55 -6.61 -0.38 2.12e-10 Coronary artery disease; CESC cis rs568617 0.903 rs601863 chr11:65646557 C/A cg19792802 chr11:65647270 CTSW -0.35 -5.31 -0.31 2.33e-7 Crohn's disease; CESC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg24549020 chr5:56110836 MAP3K1 0.68 7.76 0.43 1.85e-13 Initial pursuit acceleration; CESC cis rs1008375 1.000 rs7688682 chr4:17693794 A/G cg02297831 chr4:17616191 MED28 -0.46 -5.59 -0.32 5.75e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20782286 chr6:56298173 NA -0.58 -6.3 -0.36 1.2e-9 Gut microbiome composition (summer); CESC cis rs6459804 1.000 rs58278053 chr7:157512934 A/T cg05731713 chr7:157510257 PTPRN2 0.39 6.25 0.36 1.59e-9 Bipolar disorder and schizophrenia; CESC cis rs72781680 0.611 rs55788848 chr2:24268721 C/T cg20701182 chr2:24300061 SF3B14 0.94 10.66 0.55 2.67e-22 Lymphocyte counts; CESC cis rs34779708 0.801 rs12098720 chr10:35538683 G/A cg04310649 chr10:35416472 CREM -0.47 -5.36 -0.31 1.83e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs10979 1.000 rs9399448 chr6:143896315 G/T cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs6741892 0.536 rs7590835 chr2:38893950 A/G cg23643435 chr2:38893251 GALM 0.63 8.81 0.48 1.64e-16 5-HTT brain serotonin transporter levels; CESC cis rs4423214 0.569 rs12806918 chr11:71119018 G/T cg05163923 chr11:71159392 DHCR7 0.6 8.09 0.44 2.17e-14 Vitamin D levels; CESC cis rs977987 0.806 rs8051407 chr16:75448659 A/G cg03315344 chr16:75512273 CHST6 0.41 5.81 0.34 1.79e-8 Dupuytren's disease; CESC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg23048001 chr7:2026167 MAD1L1 0.45 5.88 0.34 1.24e-8 Bipolar disorder and schizophrenia; CESC cis rs9549367 0.789 rs12869947 chr13:113896156 A/G cg00898013 chr13:113819073 PROZ -0.52 -7.09 -0.4 1.23e-11 Platelet distribution width; CESC cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg13628971 chr7:2884303 GNA12 0.43 5.74 0.33 2.55e-8 Height; CESC cis rs3785574 0.962 rs2727280 chr17:61918082 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.74 9.17 0.49 1.32e-17 Height; CESC cis rs4704187 0.532 rs75392670 chr5:74394968 A/G cg03227963 chr5:74354835 NA 0.32 5.89 0.34 1.17e-8 Response to amphetamines; CESC cis rs7662987 0.793 rs7684735 chr4:99991506 C/T cg13256891 chr4:100009986 ADH5 -0.6 -5.19 -0.3 4.24e-7 Smoking initiation; CESC cis rs963731 0.649 rs297130 chr2:39299314 C/T cg04010122 chr2:39346883 SOS1 0.82 6.34 0.36 9.73e-10 Corticobasal degeneration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02654935 chr6:12514489 NA -0.51 -6.47 -0.37 4.75e-10 Gut microbiome composition (summer); CESC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg21782813 chr7:2030301 MAD1L1 0.5 7.18 0.4 6.92e-12 Bipolar disorder and schizophrenia; CESC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg25985355 chr7:65971099 NA 0.31 5.06 0.3 7.78e-7 Aortic root size; CESC cis rs9910055 0.530 rs8072954 chr17:42294722 G/A cg19774624 chr17:42201019 HDAC5 -0.6 -8.66 -0.47 4.63e-16 Total body bone mineral density; CESC cis rs3733585 0.806 rs7375599 chr4:9954918 C/T cg00071950 chr4:10020882 SLC2A9 0.77 13.99 0.65 1.09e-33 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7395581 0.877 rs7127907 chr11:47324472 A/C cg25783544 chr11:47291846 MADD 0.6 7.85 0.43 1.04e-13 HDL cholesterol; CESC cis rs2455799 0.533 rs2470513 chr3:15750056 G/A cg16303742 chr3:15540471 COLQ -0.39 -6.23 -0.36 1.87e-9 Mean platelet volume; CESC cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg13147721 chr7:65941812 NA -0.52 -5.54 -0.32 7.27e-8 Diabetic kidney disease; CESC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg03647317 chr4:187891568 NA -0.37 -5.56 -0.32 6.44e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7589342 0.839 rs11895235 chr2:106432355 C/G cg16077055 chr2:106428750 NCK2 0.52 7.44 0.42 1.42e-12 Addiction; CESC cis rs1144333 1.000 rs112401426 chr1:76466103 T/A cg10523679 chr1:76189770 ACADM 0.55 5.14 0.3 5.24e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.34 -0.31 2.03e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7520050 0.902 rs7514192 chr1:46248977 A/G cg24296786 chr1:45957014 TESK2 0.44 5.57 0.32 6.19e-8 Red blood cell count;Reticulocyte count; CESC cis rs6691722 0.503 rs12135404 chr1:24704263 C/T cg18323236 chr1:24743029 NIPAL3 -0.34 -5.08 -0.3 6.98e-7 Response to interferon beta in multiple sclerosis; CESC cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg10523679 chr1:76189770 ACADM -0.6 -6.31 -0.36 1.2e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs12545109 0.800 rs1595940 chr8:57398309 T/C cg09654669 chr8:57350985 NA -0.55 -6.57 -0.37 2.68e-10 Obesity-related traits; CESC cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 2e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.884 rs9383864 chr6:150173105 T/C cg13206674 chr6:150067644 NUP43 0.38 5.12 0.3 5.81e-7 Lung cancer; CESC cis rs2637266 0.935 rs1907323 chr10:78336015 C/T cg18941641 chr10:78392320 NA 0.4 7.52 0.42 8.48e-13 Pulmonary function; CESC cis rs698833 0.886 rs4953086 chr2:44561532 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 6.39 0.37 7.31e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs698833 0.892 rs2603257 chr2:44731588 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.77 0.33 2.24e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg23711669 chr6:146136114 FBXO30 -0.94 -11.89 -0.59 2.05e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs11718455 0.767 rs6782500 chr3:43990260 A/G cg08738300 chr3:44038990 NA -0.46 -6.09 -0.35 3.85e-9 Coronary artery disease; CESC cis rs763014 0.833 rs3743903 chr16:632736 T/C cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01076405 chr8:99057832 RPL30 0.59 6.57 0.37 2.72e-10 Gut microbiome composition (summer); CESC cis rs66569888 0.754 rs6719028 chr2:106895212 T/C cg23109721 chr2:106886537 NA 0.51 5.7 0.33 3.26e-8 Facial morphology (factor 23); CESC cis rs60871478 0.735 rs4721501 chr7:862166 G/T cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.56 -5.29 -0.31 2.57e-7 Cerebrospinal P-tau181p levels; CESC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg22508957 chr16:3507546 NAT15 -0.56 -7.78 -0.43 1.61e-13 Tuberculosis; CESC cis rs116095464 0.558 rs7708182 chr5:234788 C/G cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.23 0.31 3.39e-7 Breast cancer; CESC cis rs644799 0.965 rs687529 chr11:95545587 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs8062405 1.000 rs9972693 chr16:28859802 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs12310956 0.532 rs10844719 chr12:33987714 A/G cg26384229 chr12:38710491 ALG10B 0.47 6.5 0.37 4.04e-10 Morning vs. evening chronotype; CESC cis rs4835473 0.897 rs11728121 chr4:144628232 C/T cg25736465 chr4:144833511 NA 0.44 6.65 0.38 1.64e-10 Immature fraction of reticulocytes; CESC cis rs3749237 0.595 rs11130199 chr3:49538799 T/C cg07636037 chr3:49044803 WDR6 0.64 9.26 0.49 7.21e-18 Resting heart rate; CESC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg17724175 chr1:150552817 MCL1 0.34 5.24 0.31 3.34e-7 Melanoma; CESC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg22105103 chr4:187893119 NA 0.48 6.77 0.38 8.02e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9796 0.689 rs9888718 chr15:41446254 T/G cg18705301 chr15:41695430 NDUFAF1 -0.48 -7.09 -0.4 1.25e-11 Menopause (age at onset); CESC cis rs7580658 0.963 rs12052483 chr2:128136820 T/G cg10021288 chr2:128175891 PROC -0.41 -6.47 -0.37 4.66e-10 Protein C levels; CESC cis rs2933343 0.700 rs1680779 chr3:128614770 G/A cg25356066 chr3:128598488 ACAD9 0.62 8.45 0.46 1.94e-15 IgG glycosylation; CESC cis rs6964587 0.900 rs6972027 chr7:91781380 T/C cg17063962 chr7:91808500 NA 0.59 8.24 0.45 8.03e-15 Breast cancer; CESC cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg01475377 chr6:109611718 NA -0.44 -7.0 -0.39 2.15e-11 Reticulocyte fraction of red cells; CESC cis rs9457247 0.967 rs2769355 chr6:167380493 G/A cg25258033 chr6:167368657 RNASET2 -0.42 -6.24 -0.36 1.77e-9 Crohn's disease; CESC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.32 -0.31 2.21e-7 Total body bone mineral density; CESC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg00484396 chr16:3507460 NAT15 -0.54 -6.04 -0.35 5.1e-9 Tuberculosis; CESC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.4 0.5 2.72e-18 Menopause (age at onset); CESC cis rs7193541 0.585 rs7978 chr16:74486189 T/C cg05580060 chr16:74700937 RFWD3 0.42 5.26 0.31 2.98e-7 Multiple myeloma; CESC cis rs2979489 0.786 rs1106352 chr8:30404671 C/T cg26383811 chr8:30366931 RBPMS -0.78 -9.85 -0.52 1.05e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12199165 chr10:103577593 MGEA5 0.6 7.22 0.41 5.65e-12 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg26314531 chr2:26401878 FAM59B -0.58 -6.53 -0.37 3.34e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.570 rs12159188 chr22:42121125 A/T cg06481639 chr22:41940642 POLR3H 0.56 6.12 0.35 3.29e-9 Vitiligo; CESC cis rs870825 0.616 rs4256263 chr4:185622959 C/A cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs73019876 0.686 rs1989119 chr19:22205665 T/G cg11619707 chr19:22235551 ZNF257 -0.27 -5.06 -0.3 7.69e-7 Testicular germ cell tumor; CESC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg01988459 chr11:68622903 NA -0.39 -5.42 -0.32 1.31e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7621025 0.630 rs1681818 chr3:136473673 A/G cg15507776 chr3:136538369 TMEM22 -0.56 -6.53 -0.37 3.43e-10 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs6088590 0.965 rs6058108 chr20:33288655 A/G cg24642439 chr20:33292090 TP53INP2 0.81 11.44 0.58 6.52e-25 Coronary artery disease; CESC cis rs8072100 0.544 rs9284377 chr17:45386412 C/T cg25173405 chr17:45401733 C17orf57 -0.42 -5.25 -0.31 3.19e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2479106 0.549 rs1975064 chr9:126397618 T/A cg16191174 chr9:126692580 DENND1A 0.39 5.4 0.31 1.49e-7 Polycystic ovary syndrome; CESC cis rs10752881 0.901 rs10911201 chr1:183001622 G/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Colorectal cancer; CESC cis rs34779708 0.900 rs73262807 chr10:35496386 C/T cg03585969 chr10:35415529 CREM 0.75 9.92 0.52 6.22e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs2180341 0.960 rs9398840 chr6:127669744 G/A cg24812749 chr6:127587940 RNF146 1.05 15.07 0.68 1.77e-37 Breast cancer; CESC cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.76e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2806561 0.765 rs623988 chr1:23519477 C/T cg12483005 chr1:23474871 LUZP1 0.38 6.03 0.35 5.41e-9 Height; CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg04025307 chr7:1156635 C7orf50 0.54 9.1 0.49 2.21e-17 Longevity;Endometriosis; CESC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg19468946 chr17:37922297 IKZF3 0.42 5.22 0.31 3.62e-7 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.64 0.42 4.1e-13 Prudent dietary pattern; CESC cis rs8064299 0.503 rs11653346 chr17:72773333 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.58 7.92 0.44 6.67e-14 Monocyte count; CESC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg10074409 chr1:209979377 IRF6 0.35 5.68 0.33 3.46e-8 Cleft lip with or without cleft palate; CESC cis rs3806843 1.000 rs3756340 chr5:140180451 T/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.24 -0.31 3.26e-7 Depressive symptoms (multi-trait analysis); CESC cis rs79839061 0.610 rs3775122 chr4:893287 A/G cg07828340 chr4:882639 GAK -0.99 -7.66 -0.43 3.51e-13 Intelligence (multi-trait analysis); CESC cis rs782590 0.774 rs782629 chr2:55900283 C/T cg18811423 chr2:55921094 PNPT1 -0.77 -13.31 -0.63 2.71e-31 Metabolic syndrome; CESC cis rs9399135 0.967 rs7750300 chr6:135350950 C/G cg24558204 chr6:135376177 HBS1L 0.51 7.09 0.4 1.2e-11 Red blood cell count; CESC cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg05340658 chr4:99064831 C4orf37 0.84 13.05 0.63 2.09e-30 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08187083 chr17:30186506 C17orf79 -0.45 -6.01 -0.35 6.1e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9788682 0.747 rs8042494 chr15:78908010 C/T cg24631222 chr15:78858424 CHRNA5 0.77 9.42 0.5 2.33e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs6460942 1.000 rs7791634 chr7:12401482 A/T cg13733410 chr7:12443478 VWDE -0.54 -5.35 -0.31 1.9e-7 Coronary artery disease; CESC cis rs7851660 0.935 rs4460498 chr9:100620412 T/C cg13688889 chr9:100608707 NA -0.7 -10.5 -0.54 8.43e-22 Strep throat; CESC cis rs2228479 0.557 rs11641726 chr16:89891619 G/A cg06558623 chr16:89946397 TCF25 1.12 8.24 0.45 7.86e-15 Skin colour saturation; CESC trans rs4665809 1.000 rs6546768 chr2:26328800 A/G cg09258813 chr8:37823409 ADRB3 -0.37 -6.1 -0.35 3.65e-9 Gut microbiome composition (summer); CESC trans rs72681920 0.881 rs17028765 chr4:100188396 T/C cg22948791 chr15:71404101 CT62 -0.54 -6.07 -0.35 4.35e-9 Alcohol dependence; CESC trans rs1493916 0.905 rs9956315 chr18:31405546 G/C cg27147174 chr7:100797783 AP1S1 -0.55 -7.39 -0.41 1.87e-12 Life satisfaction; CESC cis rs4242434 0.854 rs13258100 chr8:22451116 A/T cg03733263 chr8:22462867 KIAA1967 0.9 12.75 0.62 2.28e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs2243480 1.000 rs316334 chr7:65602126 G/T cg18252515 chr7:66147081 NA -1.42 -14.5 -0.67 1.8e-35 Diabetic kidney disease; CESC cis rs2996428 0.601 rs10909804 chr1:3770929 A/G cg23277830 chr1:3704460 LRRC47 -0.35 -5.32 -0.31 2.25e-7 Red cell distribution width; CESC cis rs6570726 0.902 rs9390326 chr6:145791222 A/G cg05347473 chr6:146136440 FBXO30 -0.42 -5.63 -0.33 4.54e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs796364 0.806 rs34582889 chr2:201010527 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -6.43 -0.37 5.87e-10 Schizophrenia; CESC cis rs921968 0.608 rs11678428 chr2:219352598 C/T cg02176678 chr2:219576539 TTLL4 0.39 6.72 0.38 1.09e-10 Mean corpuscular hemoglobin concentration; CESC cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg14345882 chr6:26364793 BTN3A2 0.42 5.17 0.3 4.56e-7 Intelligence (multi-trait analysis); CESC trans rs7618501 0.633 rs2883057 chr3:49998282 C/T cg21659725 chr3:3221576 CRBN 0.55 7.6 0.42 5.29e-13 Intelligence (multi-trait analysis); CESC cis rs6460942 0.597 rs13232817 chr7:12551909 C/A cg06484146 chr7:12443880 VWDE -0.71 -7.15 -0.4 8.67e-12 Coronary artery disease; CESC cis rs1949733 1.000 rs3103072 chr4:8508431 C/T cg11789530 chr4:8429930 ACOX3 -0.74 -10.13 -0.53 1.38e-20 Response to antineoplastic agents; CESC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg26335602 chr6:28129616 ZNF389 0.55 7.32 0.41 2.89e-12 Depression; CESC cis rs15676 0.783 rs2417126 chr9:131562457 C/T cg00228799 chr9:131580591 ENDOG -0.49 -6.09 -0.35 3.93e-9 Blood metabolite levels; CESC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg27170947 chr2:26402098 FAM59B -0.72 -8.31 -0.45 5.18e-15 Gut microbiome composition (summer); CESC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg17724175 chr1:150552817 MCL1 -0.5 -7.81 -0.43 1.35e-13 Urate levels; CESC cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg23711669 chr6:146136114 FBXO30 -0.94 -14.45 -0.66 2.66e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs7580658 0.750 rs6731176 chr2:128071003 C/T cg10021288 chr2:128175891 PROC -0.37 -5.98 -0.35 7.04e-9 Protein C levels; CESC cis rs7116495 0.609 rs73531955 chr11:71687794 A/C cg18441811 chr11:71824068 C11orf51 0.8 5.13 0.3 5.49e-7 Severe influenza A (H1N1) infection; CESC cis rs3736485 0.966 rs11636170 chr15:51767087 G/T cg08986416 chr15:51914746 DMXL2 -0.4 -5.21 -0.3 3.85e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.91 13.81 0.65 4.68e-33 Prudent dietary pattern; CESC cis rs910316 0.870 rs7147712 chr14:75670707 C/G cg11812906 chr14:75593930 NEK9 -0.81 -13.08 -0.63 1.7e-30 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02951021 chr12:120934296 DYNLL1 -0.4 -6.22 -0.36 1.96e-9 Gambling; CESC cis rs11997175 0.509 rs67427312 chr8:33674377 A/G ch.8.33884649F chr8:33765107 NA 0.5 6.33 0.36 1.05e-9 Body mass index; CESC cis rs9911578 0.967 rs8182277 chr17:57144367 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.19 0.3 4.11e-7 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Depression; CESC cis rs1215050 0.776 rs1627946 chr4:98844416 G/A cg05340658 chr4:99064831 C4orf37 -0.5 -6.42 -0.37 6.44e-10 Waist-to-hip ratio adjusted for body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16326609 chr14:70883772 SYNJ2BP -0.48 -6.05 -0.35 4.85e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8177253 0.555 rs4481157 chr3:133464684 G/A cg18769074 chr3:133464867 TF 0.3 5.69 0.33 3.35e-8 Iron status biomarkers; CESC cis rs9287719 0.934 rs12692416 chr2:10745627 A/G cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC cis rs6121246 0.909 rs6060812 chr20:30292803 C/T cg13852791 chr20:30311386 BCL2L1 0.79 8.37 0.46 3.41e-15 Mean corpuscular hemoglobin; CESC cis rs644799 0.930 rs587123 chr11:95560539 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.25 0.66 1.39e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs7917772 0.560 rs10786697 chr10:104378563 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.38 5.27 0.31 2.82e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.58 -7.28 -0.41 3.78e-12 Height; CESC cis rs7072216 0.806 rs9804285 chr10:100169472 C/T cg26618903 chr10:100175079 PYROXD2 -0.37 -5.7 -0.33 3.16e-8 Metabolite levels; CESC cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg02187348 chr16:89574699 SPG7 0.47 6.17 0.35 2.59e-9 Multiple myeloma (IgH translocation); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18253787 chr19:2757657 SGTA 0.45 6.12 0.35 3.44e-9 Fibrinogen levels; CESC cis rs290986 0.857 rs167080 chr9:93553577 T/C cg02608019 chr9:93564028 SYK -0.53 -5.63 -0.33 4.66e-8 Multiple sclerosis; CESC cis rs7635838 0.892 rs9310379 chr3:11434143 C/T cg00170343 chr3:11313890 ATG7 -0.42 -5.55 -0.32 6.85e-8 HDL cholesterol; CESC cis rs1348850 0.598 rs1405717 chr2:178500101 G/T cg22681709 chr2:178499509 PDE11A -0.56 -8.88 -0.48 1.06e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10832963 1.000 rs2084220 chr11:18656932 C/T cg20219074 chr11:18656078 SPTY2D1 0.8 11.72 0.58 7.97e-26 Breast cancer; CESC cis rs4237845 0.636 rs11172371 chr12:58286188 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.51 5.45 0.32 1.13e-7 Intelligence (multi-trait analysis); CESC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg18252515 chr7:66147081 NA -0.43 -5.6 -0.33 5.39e-8 Aortic root size; CESC cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg21573476 chr21:45109991 RRP1B -0.58 -8.47 -0.46 1.7e-15 Mean corpuscular volume; CESC cis rs17253792 0.915 rs17832389 chr14:56185836 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.72 5.06 0.3 7.74e-7 Putamen volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04436474 chr3:49977685 RBM6 -0.43 -6.24 -0.36 1.72e-9 Gambling; CESC cis rs1372520 0.577 rs748849 chr4:90734961 G/A cg15133208 chr4:90757351 SNCA -0.41 -5.55 -0.32 6.81e-8 Neuroticism; CESC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.38 0.31 1.66e-7 Tonsillectomy; CESC cis rs12155623 0.668 rs6472114 chr8:49789561 T/C cg22283653 chr8:49824208 NA -0.38 -6.09 -0.35 3.94e-9 Sudden cardiac arrest; CESC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg20151795 chr6:28129481 ZNF389 0.41 5.56 0.32 6.63e-8 Depression; CESC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg11987759 chr7:65425863 GUSB -0.43 -5.75 -0.33 2.46e-8 Aortic root size; CESC cis rs11792861 0.641 rs10979586 chr9:111647764 C/T cg13535736 chr9:111863775 C9orf5 -0.43 -5.6 -0.33 5.28e-8 Menarche (age at onset); CESC cis rs1691799 0.899 rs1183272 chr12:66735421 T/C cg16791601 chr12:66731901 HELB -0.79 -14.29 -0.66 9.69e-35 White blood cell count (basophil); CESC cis rs2108225 0.658 rs1476673 chr7:107435945 C/G cg18560240 chr7:107437656 SLC26A3 -0.5 -7.0 -0.39 2.12e-11 Ulcerative colitis; CESC cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg24308560 chr3:49941425 MST1R 0.6 8.65 0.47 5.02e-16 Body mass index; CESC cis rs847577 0.630 rs6967926 chr7:97715088 C/T cg21770322 chr7:97807741 LMTK2 0.84 15.22 0.68 5.14e-38 Breast cancer; CESC cis rs73206853 0.841 rs74503171 chr12:111061652 A/G cg12870014 chr12:110450643 ANKRD13A 0.62 5.17 0.3 4.63e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs1814175 0.645 rs10128731 chr11:50023554 G/T cg03929089 chr4:120376271 NA -0.9 -14.7 -0.67 3.47e-36 Height; CESC cis rs523522 0.962 rs4767905 chr12:120930835 C/T cg12219531 chr12:120966889 COQ5 0.74 9.94 0.52 5.49e-20 High light scatter reticulocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18530282 chr10:115439379 CASP7 -0.45 -6.14 -0.35 3.04e-9 Fibrinogen levels; CESC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg10691866 chr7:65817282 TPST1 0.34 5.61 0.33 5.03e-8 Aortic root size; CESC cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs863345 0.604 rs923664 chr1:158507691 A/T cg12129480 chr1:158549410 OR10X1 -0.35 -7.03 -0.4 1.73e-11 Pneumococcal bacteremia; CESC cis rs933688 0.532 rs12514092 chr5:90540522 T/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.42 -5.03 -0.3 9.14e-7 Smoking behavior; CESC cis rs2228479 0.867 rs11646448 chr16:89966357 A/T cg00800038 chr16:89945340 TCF25 -0.84 -8.15 -0.45 1.42e-14 Skin colour saturation; CESC cis rs3916 0.641 rs7964786 chr12:121132100 C/T cg20569203 chr12:120799911 MSI1 0.3 5.07 0.3 7.58e-7 Urinary metabolites (H-NMR features); CESC cis rs1707322 0.963 rs12145287 chr1:46325002 C/G cg06784218 chr1:46089804 CCDC17 0.35 5.87 0.34 1.33e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7255436 0.965 rs11666233 chr19:8452045 G/T cg10174797 chr19:8464628 RAB11B 0.38 5.43 0.32 1.28e-7 HDL cholesterol; CESC cis rs7666738 0.830 rs13141752 chr4:98893128 G/A cg17366294 chr4:99064904 C4orf37 0.56 7.75 0.43 1.99e-13 Colonoscopy-negative controls vs population controls; CESC cis rs9902453 1.000 rs9902453 chr17:28349095 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.85 -0.43 1.04e-13 Coffee consumption (cups per day); CESC cis rs9287719 0.967 rs7600820 chr2:10740044 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs6964587 0.626 rs2269810 chr7:91508837 T/C cg17063962 chr7:91808500 NA -0.44 -6.18 -0.35 2.45e-9 Breast cancer; CESC cis rs2180341 0.960 rs7745944 chr6:127709574 A/G cg27446573 chr6:127587934 RNF146 1.04 14.72 0.67 2.91e-36 Breast cancer; CESC cis rs6460942 0.514 rs118124486 chr7:12470381 T/G cg10578991 chr7:12443926 VWDE -0.36 -5.36 -0.31 1.77e-7 Coronary artery disease; CESC cis rs9486719 1.000 rs12201449 chr6:96959382 C/T cg18709589 chr6:96969512 KIAA0776 -0.57 -6.26 -0.36 1.53e-9 Migraine;Coronary artery disease; CESC cis rs9916302 0.680 rs2271308 chr17:37817482 T/C cg20243544 chr17:37824526 PNMT 0.58 7.14 0.4 8.81e-12 Glomerular filtration rate (creatinine); CESC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg07138768 chr7:917805 C7orf20 0.34 5.39 0.31 1.57e-7 Perceived unattractiveness to mosquitoes; CESC cis rs2243480 1.000 rs68189316 chr7:65409169 C/G cg12463550 chr7:65579703 CRCP 0.7 5.58 0.32 5.87e-8 Diabetic kidney disease; CESC trans rs61931739 0.534 rs4547187 chr12:34041259 T/C cg26384229 chr12:38710491 ALG10B 0.5 6.75 0.38 9.3e-11 Morning vs. evening chronotype; CESC cis rs6815814 0.950 rs56408159 chr4:38812116 T/A cg02016764 chr4:38805732 TLR1 -0.62 -7.43 -0.42 1.5e-12 Breast cancer; CESC cis rs34779708 0.966 rs7913615 chr10:35422957 T/G cg04310649 chr10:35416472 CREM -0.49 -5.85 -0.34 1.41e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs796364 0.806 rs74771155 chr2:200913743 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC cis rs1538970 0.924 rs3790582 chr1:45887288 T/C cg24296786 chr1:45957014 TESK2 -0.46 -5.29 -0.31 2.54e-7 Platelet count; CESC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg03396347 chr1:1875803 NA -0.45 -7.07 -0.4 1.34e-11 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23145915 chr12:58146234 CDK4 0.59 6.81 0.39 6.35e-11 Gut microbiome composition (summer); CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg26354017 chr1:205819088 PM20D1 0.98 17.44 0.73 6.64e-46 Menarche (age at onset); CESC cis rs3741151 0.892 rs76854106 chr11:73027110 G/A cg17517138 chr11:73019481 ARHGEF17 1.11 7.88 0.44 8.34e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7617773 0.817 rs3731555 chr3:48206102 G/A cg11946769 chr3:48343235 NME6 0.88 11.55 0.58 2.84e-25 Coronary artery disease; CESC cis rs3747547 0.581 rs7467749 chr9:38136965 A/T cg13774184 chr9:37916125 SHB 0.63 5.41 0.32 1.42e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg03395511 chr6:291903 DUSP22 -0.73 -9.47 -0.5 1.59e-18 Menopause (age at onset); CESC trans rs4335177 0.963 rs6477534 chr9:109365066 G/A cg12580783 chr12:49362475 WNT10B -0.32 -6.19 -0.36 2.25e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs9291683 0.527 rs3822247 chr4:10094671 G/A cg11266682 chr4:10021025 SLC2A9 -0.56 -10.49 -0.54 9.03e-22 Bone mineral density; CESC cis rs17376456 0.569 rs896729 chr5:93222178 A/G cg25358565 chr5:93447407 FAM172A -0.62 -6.65 -0.38 1.64e-10 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24928378 chr12:49259415 RND1 -0.65 -7.62 -0.42 4.64e-13 Gut microbiome composition (summer); CESC cis rs17826219 0.714 rs11650821 chr17:28968150 T/C cg14008862 chr17:28927542 LRRC37B2 0.75 5.5 0.32 9.05e-8 Body mass index; CESC cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg06212747 chr3:49208901 KLHDC8B 0.66 8.79 0.47 1.99e-16 Parkinson's disease; CESC cis rs6867032 0.958 rs4975798 chr5:2015580 G/A cg26168224 chr5:2018326 NA 0.96 19.64 0.77 1.3e-53 Gut microbiome composition (winter); CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg11905131 chr22:24372483 LOC391322 0.81 12.19 0.6 1.91e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11039798 0.588 rs666165 chr11:48457439 C/T cg15704280 chr7:45808275 SEPT13 -0.6 -6.32 -0.36 1.11e-9 Axial length; CESC cis rs7914558 0.933 rs10786729 chr10:104719378 A/G cg08650961 chr10:104748594 CNNM2 0.32 5.17 0.3 4.66e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs11098499 0.789 rs9991166 chr4:120237851 G/A cg09307838 chr4:120376055 NA 0.79 10.77 0.55 1.17e-22 Corneal astigmatism; CESC cis rs7647973 1.000 rs7647973 chr3:49510931 G/A cg06212747 chr3:49208901 KLHDC8B -0.56 -6.93 -0.39 3.22e-11 Menarche (age at onset); CESC cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.58 5.76 0.33 2.36e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8028182 0.636 rs7495610 chr15:75784441 T/C cg20655648 chr15:75932815 IMP3 0.48 5.97 0.34 7.42e-9 Sudden cardiac arrest; CESC cis rs9487051 0.676 rs7773213 chr6:109601885 C/T cg12927641 chr6:109611667 NA -0.37 -5.51 -0.32 8.39e-8 Reticulocyte fraction of red cells; CESC cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg20503657 chr10:835505 NA 0.63 5.49 0.32 9.26e-8 Eosinophil percentage of granulocytes; CESC trans rs9858542 1.000 rs9882740 chr3:49702484 T/C cg21659725 chr3:3221576 CRBN -0.53 -6.56 -0.37 2.83e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7959452 0.535 rs2305641 chr12:69646914 C/T cg14784868 chr12:69753453 YEATS4 0.71 10.3 0.53 3.85e-21 Blood protein levels; CESC cis rs116095464 0.558 rs10462754 chr5:246669 T/C cg10591111 chr5:226296 SDHA -0.51 -6.28 -0.36 1.38e-9 Breast cancer; CESC cis rs6439153 0.901 rs2630263 chr3:128688318 A/G cg24203234 chr3:128598194 ACAD9 0.42 5.49 0.32 9.48e-8 Pneumococcal bacteremia; CESC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg25767906 chr1:53392781 SCP2 -0.54 -7.54 -0.42 7.6e-13 Monocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22225685 chr22:38203998 GCAT -0.42 -6.13 -0.35 3.1e-9 Fibrinogen levels; CESC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg20151795 chr6:28129481 ZNF389 0.43 5.5 0.32 9.14e-8 Depression; CESC cis rs1707322 1.000 rs7547284 chr1:46319565 C/G cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3857067 0.839 rs12505694 chr4:95042940 T/G cg11021082 chr4:95130006 SMARCAD1 -0.51 -7.74 -0.43 2.06e-13 QT interval; CESC cis rs14057 0.896 rs2235566 chr1:6655053 G/A cg06778853 chr1:6672620 PHF13 -0.28 -5.12 -0.3 5.83e-7 Systolic blood pressure; CESC trans rs629535 0.508 rs56207225 chr8:70146628 C/A cg21567404 chr3:27674614 NA -0.83 -9.14 -0.49 1.69e-17 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03241502 chr19:7505149 ARHGEF18 -0.63 -6.89 -0.39 3.95e-11 Gut microbiome composition (summer); CESC cis rs17401966 0.931 rs1002076 chr1:10438892 G/A cg15208524 chr1:10270712 KIF1B 0.41 5.24 0.31 3.26e-7 Hepatocellular carcinoma; CESC cis rs7818345 0.967 rs6992893 chr8:19287504 G/A cg11303988 chr8:19266685 CSGALNACT1 0.36 6.63 0.38 1.9e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.717 rs1061647 chr16:89806063 G/C cg04013166 chr16:89971882 TCF25 0.78 6.57 0.37 2.64e-10 Skin colour saturation; CESC cis rs1215050 0.765 rs783947 chr4:99012943 T/C cg17366294 chr4:99064904 C4orf37 -0.39 -5.2 -0.3 4.06e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9911578 0.835 rs9303398 chr17:56484257 T/C cg05425664 chr17:57184151 TRIM37 0.44 6.14 0.35 3.03e-9 Intelligence (multi-trait analysis); CESC cis rs4268898 0.679 rs2543666 chr2:24446042 C/T cg06627628 chr2:24431161 ITSN2 0.86 10.42 0.54 1.61e-21 Asthma; CESC cis rs765787 0.530 rs7165889 chr15:45531640 T/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs6690583 0.512 rs7547224 chr1:85456902 T/C cg22153463 chr1:85462885 MCOLN2 0.77 7.18 0.4 6.91e-12 Serum sulfate level; CESC cis rs8027181 0.710 rs34117151 chr15:73097221 T/A cg25632853 chr15:73088954 NA 0.31 5.69 0.33 3.39e-8 Triglyceride levels; CESC cis rs6500602 0.927 rs7200817 chr16:4480598 G/C cg08645402 chr16:4508243 NA 0.45 7.11 0.4 1.05e-11 Schizophrenia; CESC cis rs7590720 1.000 rs4674048 chr2:216900023 G/A cg12620499 chr2:216877984 MREG 0.91 12.53 0.61 1.38e-28 Alcohol dependence; CESC trans rs1814175 0.645 rs7115592 chr11:50013243 A/G cg15704280 chr7:45808275 SEPT13 -1.0 -18.49 -0.75 1.41e-49 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08857194 chr17:77078518 ENGASE -0.69 -7.89 -0.44 8.07e-14 Gut microbiome composition (summer); CESC trans rs11098499 0.913 rs11098496 chr4:120167466 C/G cg25214090 chr10:38739885 LOC399744 0.61 8.09 0.45 2.23e-14 Corneal astigmatism; CESC trans rs9929218 0.954 rs2961 chr16:68818903 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -8.62 -0.47 5.99e-16 Colorectal cancer; CESC cis rs300703 0.542 rs376385 chr2:190245 G/A cg21211680 chr2:198530 NA 0.9 9.65 0.51 4.45e-19 Blood protein levels; CESC cis rs9814567 0.896 rs1357764 chr3:134344928 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.43 5.7 0.33 3.13e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs10751667 0.643 rs7396046 chr11:937176 T/C cg01483505 chr11:975446 AP2A2 0.38 5.18 0.3 4.33e-7 Alzheimer's disease (late onset); CESC cis rs11264213 0.901 rs116757422 chr1:36349560 G/A cg27506609 chr1:36549197 TEKT2 0.66 5.55 0.32 6.79e-8 Schizophrenia; CESC cis rs2425143 1.000 rs12481228 chr20:34218673 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -7.85 -0.43 1.02e-13 Blood protein levels; CESC cis rs2204008 0.702 rs8175764 chr12:38363690 T/C cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.62e-9 Bladder cancer; CESC cis rs9388451 0.807 rs1268065 chr6:126042783 G/A cg10911889 chr6:126070802 HEY2 -0.37 -5.28 -0.31 2.65e-7 Brugada syndrome; CESC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg13206674 chr6:150067644 NUP43 0.43 6.15 0.35 2.86e-9 Lung cancer; CESC cis rs9487051 0.676 rs1608044 chr6:109594076 T/C cg21918786 chr6:109611834 NA -0.37 -5.38 -0.31 1.62e-7 Reticulocyte fraction of red cells; CESC cis rs2929278 0.617 rs663214 chr15:44113782 T/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.54 -6.98 -0.39 2.33e-11 Schizophrenia; CESC cis rs9329289 0.610 rs10903783 chr10:2540623 C/T cg15501526 chr10:2543763 NA 0.48 7.74 0.43 2.13e-13 Age-related hearing impairment; CESC cis rs7223966 1.000 rs16947014 chr17:61719032 C/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.14 -0.3 5.32e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.05 0.35 4.95e-9 Colorectal cancer; CESC cis rs1790761 0.667 rs1254123 chr11:67334812 T/C cg24690094 chr11:67383802 NA 0.35 5.78 0.33 2.12e-8 Mean corpuscular volume; CESC cis rs1050631 1.000 rs1785914 chr18:33700796 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 -0.42 -5.43 -0.32 1.27e-7 Esophageal squamous cell cancer (length of survival); CESC cis rs9488822 0.702 rs12196154 chr6:116327471 T/G cg05304507 chr6:116381966 FRK 0.26 6.56 0.37 2.86e-10 Cholesterol, total;LDL cholesterol; CESC cis rs7714584 1.000 rs10463240 chr5:150256853 A/C cg22134413 chr5:150180641 NA 0.51 5.92 0.34 9.88e-9 Crohn's disease; CESC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.55 5.27 0.31 2.78e-7 Lung cancer in ever smokers; CESC cis rs66887589 0.748 rs28439855 chr4:120262256 G/A cg09307838 chr4:120376055 NA 0.55 7.45 0.42 1.28e-12 Diastolic blood pressure; CESC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.53 -0.37 3.29e-10 Bipolar disorder; CESC cis rs4141404 0.787 rs4820042 chr22:31589056 T/C cg13145458 chr22:31556086 RNF185 0.49 5.52 0.32 7.94e-8 Paclitaxel-induced neuropathy; CESC cis rs2797160 1.000 rs1612249 chr6:126014916 C/A cg05901451 chr6:126070800 HEY2 0.45 6.41 0.37 6.75e-10 Endometrial cancer; CESC cis rs4595586 0.545 rs1607041 chr12:39368206 C/T cg26384229 chr12:38710491 ALG10B 0.62 8.69 0.47 3.89e-16 Morning vs. evening chronotype; CESC cis rs34638657 0.872 rs2967352 chr16:82196676 T/C cg09439754 chr16:82129088 HSD17B2 -0.36 -5.27 -0.31 2.85e-7 Lung adenocarcinoma; CESC cis rs3796352 1.000 rs13078971 chr3:53103645 G/C cg07884673 chr3:53033167 SFMBT1 0.67 5.73 0.33 2.67e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs4664308 0.692 rs13009231 chr2:160964057 G/T cg03641300 chr2:160917029 PLA2R1 -0.44 -6.19 -0.36 2.29e-9 Idiopathic membranous nephropathy; CESC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 6.35 0.36 9.17e-10 Electroencephalogram traits; CESC cis rs9948 0.881 rs3731941 chr2:97476219 A/G cg01990225 chr2:97406019 LMAN2L -0.85 -5.92 -0.34 9.78e-9 Erectile dysfunction and prostate cancer treatment; CESC trans rs3816788 0.792 rs7013323 chr8:21869024 C/G cg16253641 chr1:85929949 DDAH1 -0.39 -6.13 -0.35 3.15e-9 Lung cancer in ever smokers; CESC cis rs57221529 0.766 rs72703026 chr5:572383 G/A cg16447950 chr5:562315 NA -0.7 -7.05 -0.4 1.59e-11 Lung disease severity in cystic fibrosis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23682007 chr1:167523064 CREG1 -0.46 -6.58 -0.37 2.56e-10 Asthma; CESC cis rs2658782 1.000 rs2658778 chr11:93148948 C/G cg15737290 chr11:93063684 CCDC67 0.49 6.11 0.35 3.52e-9 Pulmonary function decline; CESC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 6.75 0.38 9.2e-11 Bipolar disorder; CESC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg12963246 chr6:28129442 ZNF389 0.43 6.31 0.36 1.15e-9 Cardiac Troponin-T levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05133009 chr12:121711847 CAMKK2 0.57 7.8 0.43 1.41e-13 Fibrinogen levels; CESC cis rs3026101 0.671 rs1806258 chr17:5314956 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.41 5.36 0.31 1.8e-7 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26120680 chr9:34612489 C9orf23 -0.55 -6.37 -0.36 8.42e-10 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg19077165 chr18:44547161 KATNAL2 -0.5 -6.99 -0.39 2.26e-11 Personality dimensions; CESC cis rs1267303 0.600 rs57100184 chr1:47004710 A/C cg25110126 chr1:46999211 NA 1.08 11.9 0.59 1.88e-26 Monobrow; CESC cis rs910316 0.789 rs4899552 chr14:75667921 C/A cg08847533 chr14:75593920 NEK9 -0.85 -13.7 -0.64 1.17e-32 Height; CESC cis rs8114671 0.804 rs6088666 chr20:33564570 A/G cg06115741 chr20:33292138 TP53INP2 0.46 5.46 0.32 1.09e-7 Height; CESC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.74e-9 Prudent dietary pattern; CESC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg19717773 chr7:2847554 GNA12 -0.44 -6.46 -0.37 4.99e-10 Height; CESC cis rs12449000 1 rs12449000 chr16:89872970 T/C cg27121462 chr16:89883253 FANCA 0.71 9.78 0.51 1.79e-19 Schizophrenia; CESC cis rs35110281 0.714 rs2282526 chr21:45080552 A/T cg21573476 chr21:45109991 RRP1B -0.55 -7.58 -0.42 6.01e-13 Mean corpuscular volume; CESC cis rs2635047 0.811 rs12957869 chr18:44786869 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 5.64 0.33 4.41e-8 Educational attainment; CESC cis rs17253792 0.545 rs35466279 chr14:56017022 C/T cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs2625529 0.775 rs4777466 chr15:72136872 C/T cg16672083 chr15:72433130 SENP8 -0.49 -7.15 -0.4 8.24e-12 Red blood cell count; CESC trans rs561341 1.000 rs56903735 chr17:30254393 T/A cg27661571 chr11:113659931 NA -0.69 -6.93 -0.39 3.28e-11 Hip circumference adjusted for BMI; CESC cis rs3820068 0.581 rs72645895 chr1:15931709 G/A cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg18252515 chr7:66147081 NA 0.45 5.88 0.34 1.22e-8 Aortic root size; CESC cis rs72627123 0.619 rs79575309 chr14:74590230 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.05 0.3 8.41e-7 Morning vs. evening chronotype; CESC cis rs11250464 1.000 rs11250464 chr10:1406364 A/G cg26394196 chr10:1453818 ADARB2 -0.4 -5.41 -0.32 1.44e-7 Radiation response; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg11254527 chr1:35873695 ZMYM4 0.39 6.02 0.35 5.89e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs7839040 0.698 rs10094060 chr8:82930327 G/C cg14472086 chr9:107730925 NA -0.48 -6.45 -0.37 5.4e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs7116495 1.000 rs3018302 chr11:71790942 A/C cg26138937 chr11:71823887 C11orf51 -0.88 -7.11 -0.4 1.08e-11 Severe influenza A (H1N1) infection; CESC cis rs801193 0.548 rs2659904 chr7:66178602 C/A cg12463550 chr7:65579703 CRCP 0.54 6.86 0.39 4.77e-11 Aortic root size; CESC cis rs11785400 0.963 rs4579507 chr8:143733663 C/G cg24634471 chr8:143751801 JRK 0.46 6.14 0.35 3.02e-9 Schizophrenia; CESC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg17724175 chr1:150552817 MCL1 0.38 5.9 0.34 1.13e-8 Melanoma; CESC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg11890956 chr21:40555474 PSMG1 1.03 16.48 0.71 1.71e-42 Cognitive function; CESC cis rs2439831 0.681 rs999047 chr15:43688916 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.8 11.56 0.58 2.63e-25 Lung cancer in ever smokers; CESC cis rs3105593 0.933 rs11633404 chr15:50899309 C/A cg08437265 chr15:50716283 USP8 0.43 5.54 0.32 7.32e-8 QT interval; CESC cis rs2108622 0.727 rs3093207 chr19:15988658 T/C cg13772218 chr19:15982569 NA 0.31 5.89 0.34 1.18e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg18016565 chr1:150552671 MCL1 0.33 5.16 0.3 4.96e-7 Tonsillectomy; CESC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg13206674 chr6:150067644 NUP43 0.4 5.69 0.33 3.34e-8 Lung cancer; CESC cis rs6089584 0.627 rs55875402 chr20:60559925 G/A cg06108461 chr20:60628389 TAF4 -0.52 -6.87 -0.39 4.66e-11 Body mass index; CESC cis rs7937682 0.737 rs679032 chr11:111423286 G/T cg22437258 chr11:111473054 SIK2 0.61 7.51 0.42 8.99e-13 Primary sclerosing cholangitis; CESC cis rs734999 0.545 rs10910106 chr1:2538886 G/T cg20673091 chr1:2541236 MMEL1 0.46 7.59 0.42 5.5e-13 Ulcerative colitis; CESC cis rs12586317 0.514 rs74590021 chr14:35490113 T/G cg05294307 chr14:35346193 BAZ1A -0.51 -5.43 -0.32 1.26e-7 Psoriasis; CESC cis rs3740713 1.000 rs73440604 chr11:18463671 C/T cg23797887 chr11:18477753 LDHAL6A -0.53 -5.13 -0.3 5.58e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs12477438 0.765 rs13406288 chr2:99589585 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.46e-16 Chronic sinus infection; CESC cis rs67478160 0.608 rs4906368 chr14:104242397 A/C cg01849466 chr14:104193079 ZFYVE21 -0.55 -8.0 -0.44 4.01e-14 Schizophrenia; CESC cis rs787274 0.867 rs786978 chr9:115460239 A/G cg13803584 chr9:115635662 SNX30 -0.51 -5.2 -0.3 4.01e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg13206674 chr6:150067644 NUP43 0.45 6.52 0.37 3.57e-10 Lung cancer; CESC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg19346786 chr7:2764209 NA -0.38 -5.76 -0.33 2.34e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs992157 0.798 rs12053514 chr2:219167965 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.65 -8.49 -0.46 1.5e-15 Colorectal cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg17955575 chr17:73761019 GALK1 -0.48 -6.18 -0.35 2.35e-9 Asthma; CESC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.9 10.3 0.53 3.74e-21 Mean platelet volume; CESC cis rs854765 0.551 rs56886154 chr17:17831473 C/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.52 7.22 0.41 5.4e-12 Total body bone mineral density; CESC cis rs8044868 0.521 rs7203821 chr16:72101165 T/C cg01557791 chr16:72042693 DHODH -0.41 -5.57 -0.32 6.1e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13896783 chr2:159313876 CCDC148;PKP4 0.52 6.06 0.35 4.66e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg03676636 chr4:99064102 C4orf37 0.33 5.07 0.3 7.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg23711669 chr6:146136114 FBXO30 0.95 12.52 0.61 1.41e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg00409905 chr10:38381863 ZNF37A -0.47 -6.29 -0.36 1.31e-9 Extrinsic epigenetic age acceleration; CESC cis rs897080 0.552 rs1067365 chr2:44655398 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.92 0.34 9.71e-9 Height; CESC cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg00750074 chr16:89608354 SPG7 -0.37 -5.26 -0.31 2.99e-7 Multiple myeloma (IgH translocation); CESC cis rs6028335 0.867 rs67114385 chr20:37696401 C/T cg16355469 chr20:37678765 NA 0.55 5.29 0.31 2.54e-7 Alcohol and nicotine co-dependence; CESC cis rs11098499 0.739 rs6534130 chr4:120131339 A/T cg09307838 chr4:120376055 NA -0.66 -8.14 -0.45 1.52e-14 Corneal astigmatism; CESC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs2236918 0.710 rs2797602 chr1:242029206 G/T cg17736920 chr1:242011382 EXO1 0.55 6.97 0.39 2.5e-11 Menopause (age at onset); CESC cis rs1348850 0.668 rs13010396 chr2:178492934 T/C cg23306229 chr2:178417860 TTC30B 0.56 6.57 0.37 2.69e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11098499 0.570 rs6832740 chr4:120546136 T/C cg09307838 chr4:120376055 NA 0.74 9.88 0.52 8.51e-20 Corneal astigmatism; CESC cis rs17209837 1.000 rs17149640 chr7:87086039 A/C cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC cis rs6424115 1.000 rs7514394 chr1:24100223 A/G cg15997130 chr1:24165203 NA -0.43 -6.08 -0.35 4.24e-9 Immature fraction of reticulocytes; CESC cis rs4595586 0.644 rs10437944 chr12:39308786 A/C cg26384229 chr12:38710491 ALG10B 0.42 6.12 0.35 3.31e-9 Morning vs. evening chronotype; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg15422644 chr12:52116112 SCN8A -0.43 -6.2 -0.36 2.2e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1879734 0.731 rs59020945 chr1:54162635 A/G cg23596471 chr1:54105337 GLIS1 0.33 5.41 0.32 1.38e-7 Mitral valve prolapse; CESC cis rs1707322 0.964 rs7512395 chr1:46361177 G/A cg06784218 chr1:46089804 CCDC17 0.35 5.87 0.34 1.33e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs472402 0.623 rs7727273 chr5:6635933 A/C cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.48 -6.32 -0.36 1.1e-9 Response to amphetamines; CESC cis rs561341 0.941 rs112569713 chr17:30271738 C/T cg23018236 chr17:30244563 NA -0.47 -5.15 -0.3 5.04e-7 Hip circumference adjusted for BMI; CESC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg04369109 chr6:150039330 LATS1 -0.43 -5.83 -0.34 1.6e-8 Lung cancer; CESC cis rs1046896 0.594 rs9914570 chr17:80783721 C/T cg02398342 chr17:80708632 TBCD;FN3K 0.48 5.63 0.33 4.48e-8 Glycated hemoglobin levels; CESC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg02807482 chr3:125708958 NA -0.38 -5.05 -0.3 8.26e-7 Blood pressure (smoking interaction); CESC cis rs11785400 0.642 rs4256574 chr8:143725705 C/T cg24634471 chr8:143751801 JRK 0.46 5.82 0.34 1.73e-8 Schizophrenia; CESC cis rs9399135 0.844 rs13209789 chr6:135367916 A/G cg24558204 chr6:135376177 HBS1L 0.51 7.07 0.4 1.4e-11 Red blood cell count; CESC cis rs6740322 0.748 rs6756625 chr2:43489313 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.7 8.19 0.45 1.09e-14 Coronary artery disease; CESC cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg02297831 chr4:17616191 MED28 -0.49 -5.83 -0.34 1.58e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg19163074 chr7:65112434 INTS4L2 0.43 5.33 0.31 2.1e-7 Aortic root size; CESC cis rs977987 0.933 rs1834014 chr16:75501274 G/A cg03315344 chr16:75512273 CHST6 0.53 7.74 0.43 2.09e-13 Dupuytren's disease; CESC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg02038168 chr22:39784481 NA -0.64 -8.25 -0.45 7.52e-15 Intelligence (multi-trait analysis); CESC cis rs2268241 0.938 rs11088251 chr21:34770810 A/C cg14850771 chr21:34775459 IFNGR2 0.78 9.77 0.51 1.91e-19 Obesity-related traits; CESC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.71 11.32 0.57 1.65e-24 Personality dimensions; CESC cis rs9733 0.687 rs11204735 chr1:150841667 T/C cg13175981 chr1:150552382 MCL1 0.5 6.82 0.39 5.97e-11 Tonsillectomy; CESC cis rs681343 0.746 rs633372 chr19:49209226 G/A cg21064579 chr19:49206444 FUT2 0.52 7.26 0.41 4.33e-12 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CESC cis rs3126085 1.000 rs11485508 chr1:152253167 T/G cg03465714 chr1:152285911 FLG -0.46 -5.75 -0.33 2.42e-8 Atopic dermatitis; CESC cis rs6701037 1.000 rs6702010 chr1:175123858 C/A cg00321850 chr1:175162397 KIAA0040 -0.42 -5.85 -0.34 1.45e-8 Alcohol dependence; CESC cis rs2651899 0.872 rs207199 chr1:3076857 T/G cg22674798 chr1:3096360 PRDM16 0.39 7.57 0.42 6.36e-13 Migraine; CESC trans rs677673 0.951 rs649067 chr20:10461575 T/C cg16021678 chr13:55475951 NA 0.5 6.2 0.36 2.1e-9 Body mass index (change over time) in chronic obstructive pulmonary disease; CESC cis rs1413885 0.516 rs10158873 chr1:65836244 T/C cg14976592 chr1:65886160 LEPROT;LEPR 0.47 5.95 0.34 8.66e-9 Anticoagulant levels; CESC trans rs9937837 0.918 rs34927056 chr16:31317427 T/C cg04903759 chr3:167238645 WDR49 0.53 6.63 0.38 1.89e-10 Systemic lupus erythematosus; CESC cis rs12142240 0.698 rs41534051 chr1:46828734 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.02 0.35 5.89e-9 Menopause (age at onset); CESC cis rs35740288 0.689 rs11630688 chr15:86253279 C/T cg20737812 chr15:86336631 KLHL25 -0.37 -5.07 -0.3 7.37e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg08968635 chr6:28129556 ZNF389 0.42 5.72 0.33 2.82e-8 Depression; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg01238044 chr22:24384105 GSTT1 -0.74 -10.16 -0.53 1.08e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs1545843 0.593 rs4761068 chr12:84793969 G/C cg03015433 chr16:56623111 MT3 -0.34 -6.12 -0.35 3.37e-9 Major depressive disorder; CESC cis rs2204008 0.774 rs11180977 chr12:38263094 G/T cg13010199 chr12:38710504 ALG10B 0.51 6.29 0.36 1.29e-9 Bladder cancer; CESC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg08736216 chr1:53307985 ZYG11A -0.4 -6.79 -0.38 7.53e-11 Monocyte count; CESC cis rs2204008 0.807 rs12816136 chr12:38456037 A/G cg26384229 chr12:38710491 ALG10B -0.64 -9.53 -0.51 1.09e-18 Bladder cancer; CESC cis rs9611519 0.894 rs4821998 chr22:41468273 C/G cg03806693 chr22:41940476 POLR3H -0.57 -5.91 -0.34 1.05e-8 Neuroticism; CESC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg07936489 chr17:37558343 FBXL20 0.82 11.93 0.59 1.54e-26 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg26338869 chr17:61819248 STRADA 0.69 9.11 0.49 2.04e-17 Prudent dietary pattern; CESC cis rs3857067 1.000 rs4693364 chr4:95012284 T/A cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.53 -0.42 8.12e-13 QT interval; CESC cis rs77972916 0.611 rs10495899 chr2:43602304 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.59 -5.81 -0.34 1.75e-8 Granulocyte percentage of myeloid white cells; CESC cis rs992157 0.965 rs13427681 chr2:219167563 G/C cg20019365 chr2:219134978 PNKD;AAMP 0.77 10.91 0.56 3.92e-23 Colorectal cancer; CESC cis rs8067354 0.645 rs72838857 chr17:57836767 A/G cg13753209 chr17:57696993 CLTC 0.56 6.1 0.35 3.83e-9 Hemoglobin concentration; CESC trans rs4942242 0.663 rs9525815 chr13:44223692 T/C cg19169023 chr15:41853346 TYRO3 -0.59 -7.22 -0.41 5.54e-12 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3862260 0.509 rs1045827 chr1:120162442 C/T cg16322792 chr1:120165303 ZNF697 -0.59 -11.08 -0.56 1.08e-23 Systemic lupus erythematosus; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg22087390 chr7:98050531 NA 0.42 6.16 0.35 2.73e-9 Post-traumatic stress disorder; CESC cis rs12893668 0.703 rs4906338 chr14:104050357 A/G cg24130564 chr14:104152367 KLC1 -0.47 -5.82 -0.34 1.66e-8 Reticulocyte count; CESC cis rs7312774 0.618 rs7953093 chr12:107334540 G/A cg16260113 chr12:107380972 MTERFD3 0.79 6.83 0.39 5.68e-11 Severe influenza A (H1N1) infection; CESC cis rs6088580 0.505 rs6141503 chr20:33274469 G/A cg08999081 chr20:33150536 PIGU -0.45 -6.51 -0.37 3.73e-10 Glomerular filtration rate (creatinine); CESC trans rs1814175 0.527 rs3974435 chr11:49619533 G/A cg03929089 chr4:120376271 NA -0.72 -8.32 -0.46 4.77e-15 Height; CESC cis rs4523957 0.553 rs9909515 chr17:2039733 T/C cg16513277 chr17:2031491 SMG6 -0.78 -11.57 -0.58 2.42e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.81 11.84 0.59 3.02e-26 Systemic lupus erythematosus; CESC cis rs11112613 0.775 rs7959699 chr12:105959848 C/A cg03607813 chr12:105948248 NA 0.59 6.86 0.39 4.87e-11 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs9291683 0.588 rs3756238 chr4:10013202 C/T cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.16e-46 Bone mineral density; CESC cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg04455712 chr21:45112962 RRP1B 0.41 6.06 0.35 4.78e-9 Mean corpuscular volume; CESC trans rs7246657 0.943 rs4802136 chr19:37849811 T/A cg24637308 chr11:6592297 DNHD1 0.53 6.05 0.35 4.83e-9 Coronary artery calcification; CESC cis rs5758659 0.652 rs133301 chr22:42390093 C/T cg04733989 chr22:42467013 NAGA 0.43 5.74 0.33 2.61e-8 Cognitive function; CESC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg18180107 chr4:99064573 C4orf37 0.46 5.71 0.33 3.05e-8 Colonoscopy-negative controls vs population controls; CESC cis rs12500824 0.564 rs62300859 chr4:77285754 T/A cg20311846 chr4:77356250 SHROOM3 0.37 6.86 0.39 4.82e-11 Coronary artery disease; CESC cis rs17376456 0.877 rs7728736 chr5:93404277 C/T cg25358565 chr5:93447407 FAM172A 1.13 11.34 0.57 1.45e-24 Diabetic retinopathy; CESC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg27170947 chr2:26402098 FAM59B 0.66 7.33 0.41 2.81e-12 Gut microbiome composition (summer); CESC cis rs7527798 0.501 rs12125256 chr1:207851361 C/T cg21110645 chr1:207815933 NA -0.32 -5.7 -0.33 3.22e-8 Erythrocyte sedimentation rate; CESC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.15 0.3 4.99e-7 Menopause (age at onset); CESC cis rs6460942 0.597 rs13245635 chr7:12526454 T/A cg10578991 chr7:12443926 VWDE -0.49 -5.13 -0.3 5.63e-7 Coronary artery disease; CESC cis rs7833790 0.654 rs7835342 chr8:82698092 A/G cg06027949 chr8:82754900 SNX16 -0.43 -5.22 -0.31 3.66e-7 Diastolic blood pressure; CESC cis rs7772486 0.714 rs1883365 chr6:146076749 C/T cg05347473 chr6:146136440 FBXO30 -0.53 -6.96 -0.39 2.69e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4948102 0.595 rs7793921 chr7:56120881 G/A cg09872392 chr7:56161020 PHKG1 -0.42 -6.84 -0.39 5.32e-11 Plasma homocysteine levels (post-methionine load test); CESC trans rs4689592 0.619 rs2359011 chr4:7066052 T/G cg07817883 chr1:32538562 TMEM39B -0.53 -6.14 -0.35 2.98e-9 Monocyte percentage of white cells; CESC cis rs76878669 0.561 rs4930178 chr11:66129442 C/G cg18002602 chr11:66138449 SLC29A2 0.4 6.65 0.38 1.71e-10 Educational attainment (years of education); CESC trans rs877282 1.000 rs11253369 chr10:773610 C/G cg22713356 chr15:30763199 NA 0.92 9.21 0.49 1.05e-17 Uric acid levels; CESC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg06481639 chr22:41940642 POLR3H -0.6 -6.51 -0.37 3.68e-10 Vitiligo; CESC cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg26408565 chr15:76604113 ETFA -0.37 -5.29 -0.31 2.56e-7 Blood metabolite levels; CESC trans rs57221529 0.766 rs12522303 chr5:555564 A/C cg25482853 chr8:67687455 SGK3 1.11 11.94 0.59 1.39e-26 Lung disease severity in cystic fibrosis; CESC cis rs11098499 0.779 rs7699346 chr4:120310542 C/T cg24375607 chr4:120327624 NA 0.46 5.61 0.33 5.19e-8 Corneal astigmatism; CESC cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg12826209 chr6:26865740 GUSBL1 0.75 8.79 0.48 1.88e-16 Intelligence (multi-trait analysis); CESC cis rs6815814 0.731 rs11734342 chr4:38773109 A/G cg02016764 chr4:38805732 TLR1 -0.44 -5.98 -0.34 7.2e-9 Breast cancer; CESC cis rs9399137 0.507 rs11759077 chr6:135381351 A/G cg24558204 chr6:135376177 HBS1L 0.69 9.52 0.5 1.12e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs12973672 0.812 rs2073899 chr19:35752917 C/T cg12095397 chr19:35769544 USF2 0.44 5.49 0.32 9.31e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs526821 0.595 rs499446 chr11:55355722 A/G cg15704280 chr7:45808275 SEPT13 -0.52 -6.55 -0.37 2.99e-10 Pediatric bone mineral density (spine); CESC cis rs7560272 0.501 rs12992607 chr2:73959960 G/T cg20560298 chr2:73613845 ALMS1 0.45 6.14 0.35 3.03e-9 Schizophrenia; CESC cis rs8020095 0.571 rs6573728 chr14:67343903 G/A cg19548862 chr14:67692701 FAM71D -0.49 -5.94 -0.34 8.74e-9 Depression (quantitative trait); CESC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg24829409 chr8:58192753 C8orf71 -0.73 -9.55 -0.51 9.16e-19 Developmental language disorder (linguistic errors); CESC cis rs17401966 0.838 rs10864449 chr1:10296922 A/T cg15208524 chr1:10270712 KIF1B 0.4 5.24 0.31 3.33e-7 Hepatocellular carcinoma; CESC cis rs1577917 1.000 rs13217384 chr6:86720000 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.26 -0.36 1.5e-9 Response to antipsychotic treatment; CESC cis rs2404602 0.692 rs12594556 chr15:77165363 G/A cg22467129 chr15:76604101 ETFA -0.35 -5.23 -0.31 3.42e-7 Blood metabolite levels; CESC cis rs6545883 0.929 rs3732171 chr2:61749690 C/T cg15711740 chr2:61764176 XPO1 -0.42 -5.12 -0.3 5.78e-7 Tuberculosis; CESC trans rs57221529 0.655 rs11948381 chr5:568413 A/T cg25482853 chr8:67687455 SGK3 0.99 11.03 0.56 1.58e-23 Lung disease severity in cystic fibrosis; CESC cis rs6662572 0.737 rs11211214 chr1:46347328 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.03 -0.3 8.85e-7 Blood protein levels; CESC cis rs12545109 0.800 rs2670054 chr8:57421616 C/T cg09654669 chr8:57350985 NA -0.45 -6.27 -0.36 1.47e-9 Obesity-related traits; CESC cis rs9611519 0.929 rs926914 chr22:41418154 C/T cg03806693 chr22:41940476 POLR3H -0.58 -5.92 -0.34 9.79e-9 Neuroticism; CESC cis rs9479482 0.935 rs9479513 chr6:150367320 G/T cg03788504 chr6:150331562 NA -0.34 -6.18 -0.35 2.42e-9 Alopecia areata; CESC cis rs6500395 1.000 rs8058362 chr16:48645316 T/C cg04672837 chr16:48644449 N4BP1 0.5 6.07 0.35 4.3e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs847577 0.677 rs4729403 chr7:97707841 G/C cg24562669 chr7:97807699 LMTK2 -0.5 -7.64 -0.43 3.87e-13 Breast cancer; CESC cis rs7224314 1.000 rs62084081 chr17:65387148 G/C cg01507342 chr17:65387096 PITPNC1 -0.47 -5.73 -0.33 2.79e-8 Diisocyanate-induced asthma; CESC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.88 11.36 0.57 1.28e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg15921436 chr17:44337874 NA 0.44 5.62 0.33 4.95e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1790761 0.667 rs598811 chr11:67311676 C/T cg00290607 chr11:67383545 NA 0.39 5.47 0.32 1.04e-7 Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15222563 chr19:7745491 TRAPPC5 -0.44 -6.34 -0.36 9.9e-10 Gambling; CESC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg24846343 chr22:24311635 DDTL -0.64 -11.15 -0.56 6.53e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg27535305 chr1:53392650 SCP2 -0.32 -5.5 -0.32 9e-8 Monocyte count; CESC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.77 6.42 0.37 6.12e-10 Platelet count; CESC cis rs1008375 0.931 rs6837181 chr4:17701253 A/C cg16339924 chr4:17578868 LAP3 0.63 7.72 0.43 2.33e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6460942 0.732 rs73677576 chr7:12286535 G/A cg06484146 chr7:12443880 VWDE -0.59 -6.3 -0.36 1.25e-9 Coronary artery disease; CESC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg19346786 chr7:2764209 NA -0.46 -6.85 -0.39 5.17e-11 Height; CESC cis rs7520050 0.966 rs6695809 chr1:46285461 T/C cg24296786 chr1:45957014 TESK2 0.43 5.42 0.32 1.34e-7 Red blood cell count;Reticulocyte count; CESC cis rs12142240 0.698 rs66483119 chr1:46838389 T/C cg00530320 chr1:46809349 NSUN4 0.6 7.92 0.44 6.39e-14 Menopause (age at onset); CESC cis rs72945132 0.882 rs11235755 chr11:70136323 A/G cg14191688 chr11:70257035 CTTN 0.41 5.27 0.31 2.9e-7 Coronary artery disease; CESC cis rs7523050 0.643 rs34920128 chr1:109400889 C/T cg08274380 chr1:109419600 GPSM2 0.86 5.66 0.33 3.86e-8 Fat distribution (HIV); CESC cis rs7914558 1.000 rs943038 chr10:104826261 T/C cg08650961 chr10:104748594 CNNM2 0.31 5.19 0.3 4.18e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9916302 0.904 rs7503069 chr17:37697128 C/G cg00129232 chr17:37814104 STARD3 -0.57 -7.44 -0.42 1.39e-12 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3008870 0.755 rs1535365 chr1:67497613 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.61 7.91 0.44 7.21e-14 Lymphocyte percentage of white cells; CESC trans rs7937682 0.889 rs551825 chr11:111480116 C/G cg18187862 chr3:45730750 SACM1L 0.48 6.11 0.35 3.49e-9 Primary sclerosing cholangitis; CESC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg01516881 chr6:292596 DUSP22 -0.55 -7.12 -0.4 1.02e-11 Menopause (age at onset); CESC cis rs4764487 0.687 rs3181300 chr12:6345199 C/T cg08284733 chr12:6341482 CD9 0.34 5.07 0.3 7.64e-7 Mean platelet volume; CESC cis rs7523050 0.643 rs35050241 chr1:109404876 T/C cg08274380 chr1:109419600 GPSM2 0.85 5.82 0.34 1.74e-8 Fat distribution (HIV); CESC cis rs7927771 0.524 rs2290851 chr11:47753370 C/T cg20307385 chr11:47447363 PSMC3 -0.57 -8.01 -0.44 3.63e-14 Subjective well-being; CESC cis rs798766 1.000 rs1374469 chr4:1724799 C/T cg10756475 chr4:1757242 NA 0.45 5.81 0.34 1.75e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs7618915 0.679 rs6802320 chr3:52241835 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 5.04 0.3 8.82e-7 Bipolar disorder; CESC cis rs854765 0.583 rs9913724 chr17:17819101 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.34 0.41 2.67e-12 Total body bone mineral density; CESC cis rs72634258 0.842 rs6668846 chr1:8152102 C/G cg00042356 chr1:8021962 PARK7 -0.49 -5.04 -0.3 8.63e-7 Inflammatory bowel disease; CESC cis rs919433 0.889 rs10931782 chr2:198211579 G/A cg10820045 chr2:198174542 NA -0.41 -5.93 -0.34 9.17e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7662987 0.517 rs2602872 chr4:100038996 A/G cg13256891 chr4:100009986 ADH5 0.71 7.8 0.43 1.39e-13 Smoking initiation; CESC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg07211511 chr3:129823064 LOC729375 -0.59 -7.28 -0.41 3.84e-12 Blood pressure (smoking interaction); CESC cis rs11209002 0.567 rs2815385 chr1:67542083 A/G cg02640540 chr1:67518911 SLC35D1 0.45 5.08 0.3 7.04e-7 Crohn's disease; CESC cis rs1008375 0.863 rs2058336 chr4:17608299 T/C cg27347728 chr4:17578864 LAP3 0.44 5.32 0.31 2.17e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8062405 0.754 rs3859172 chr16:28566158 G/T cg08761264 chr16:28874980 SH2B1 -0.42 -5.08 -0.3 7.04e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9894429 0.538 rs9747080 chr17:79606704 A/G cg21984481 chr17:79567631 NPLOC4 -0.41 -6.14 -0.35 2.99e-9 Eye color traits; CESC cis rs4604732 0.631 rs12036460 chr1:247626928 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs10743315 0.557 rs17505123 chr12:19301353 G/A cg09562322 chr12:119419143 SRRM4 -0.5 -6.51 -0.37 3.65e-10 Gut microbiota (bacterial taxa); CESC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg11062466 chr8:58055876 NA 0.47 6.31 0.36 1.18e-9 Developmental language disorder (linguistic errors); CESC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg18252515 chr7:66147081 NA 0.47 6.05 0.35 4.93e-9 Aortic root size; CESC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg18876405 chr7:65276391 NA -0.52 -7.13 -0.4 9.48e-12 Aortic root size; CESC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.78 0.38 7.94e-11 Bipolar disorder; CESC cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg05340658 chr4:99064831 C4orf37 0.59 7.59 0.42 5.45e-13 Colonoscopy-negative controls vs population controls; CESC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg17178900 chr1:205818956 PM20D1 0.49 7.35 0.41 2.43e-12 Menarche (age at onset); CESC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.01 0.56 1.89e-23 Platelet count; CESC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg11890956 chr21:40555474 PSMG1 -0.69 -9.97 -0.52 4.48e-20 Menarche (age at onset); CESC cis rs10751667 0.666 rs7396059 chr11:970490 C/A cg06064525 chr11:970664 AP2A2 -0.47 -9.13 -0.49 1.87e-17 Alzheimer's disease (late onset); CESC cis rs2380220 1.000 rs2380222 chr6:95975395 C/T cg15832292 chr6:96025679 MANEA 0.68 6.31 0.36 1.14e-9 Behavioural disinhibition (generation interaction); CESC cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg13902645 chr11:5959945 NA -0.62 -7.3 -0.41 3.35e-12 DNA methylation (variation); CESC cis rs2066819 0.818 rs773652 chr12:56674766 G/A cg26714650 chr12:56694279 CS 1.29 16.3 0.71 7.7e-42 Psoriasis vulgaris; CESC trans rs11088226 0.681 rs1015047 chr21:33949423 A/G cg09050820 chr6:167586206 TCP10L2 0.92 10.22 0.53 6.75e-21 Gastritis; CESC trans rs7819412 0.505 rs67849263 chr8:11007544 G/T cg06636001 chr8:8085503 FLJ10661 -0.54 -6.44 -0.37 5.59e-10 Triglycerides; CESC cis rs1878931 0.697 rs1044390 chr16:3432594 T/A cg00484396 chr16:3507460 NAT15 -0.41 -6.36 -0.36 8.95e-10 Body mass index (adult); CESC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg01416388 chr22:39784598 NA -0.56 -6.94 -0.39 3.04e-11 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Depression; CESC cis rs1003719 0.788 rs2835593 chr21:38465873 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.78 0.47 2.02e-16 Eye color traits; CESC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg11890956 chr21:40555474 PSMG1 1.18 21.96 0.8 1.36e-61 Cognitive function; CESC cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg12756686 chr19:29218302 NA 0.54 6.48 0.37 4.43e-10 Methadone dose in opioid dependence; CESC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7223966 0.960 rs7212379 chr17:61706122 G/A cg11494091 chr17:61959527 GH2 0.4 5.44 0.32 1.22e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs8040855 0.627 rs11630697 chr15:85606445 C/G cg08123816 chr15:85640762 PDE8A -0.4 -6.0 -0.35 6.36e-9 Bulimia nervosa; CESC cis rs2486012 0.649 rs1354261 chr1:44256682 A/C cg12908607 chr1:44402522 ARTN -0.44 -5.13 -0.3 5.62e-7 Intelligence (multi-trait analysis); CESC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg11644478 chr21:40555479 PSMG1 1.04 17.8 0.74 3.62e-47 Cognitive function; CESC cis rs6456156 0.586 rs2001114 chr6:167486578 A/G cg07741184 chr6:167504864 NA 0.36 6.15 0.35 2.85e-9 Primary biliary cholangitis; CESC cis rs2051211 0.895 rs17037798 chr3:38555474 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.63 -7.22 -0.41 5.52e-12 QRS duration; CESC cis rs7845219 0.544 rs7017487 chr8:95922752 A/G cg23172400 chr8:95962367 TP53INP1 0.39 7.35 0.41 2.43e-12 Type 2 diabetes; CESC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.3 0.36 1.21e-9 Menopause (age at onset); CESC cis rs1062177 0.724 rs2964590 chr5:151118146 C/G cg00977110 chr5:151150581 G3BP1 -0.61 -6.31 -0.36 1.14e-9 Preschool internalizing problems; CESC trans rs9325144 0.647 rs10875953 chr12:39050536 G/C cg23762105 chr12:34175262 ALG10 0.46 6.01 0.35 6.13e-9 Morning vs. evening chronotype; CESC cis rs6142102 0.625 rs9753690 chr20:32540801 C/G cg08999081 chr20:33150536 PIGU 0.34 5.12 0.3 5.84e-7 Skin pigmentation; CESC cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg00409905 chr10:38381863 ZNF37A -0.47 -6.26 -0.36 1.52e-9 Extrinsic epigenetic age acceleration; CESC cis rs10754283 0.967 rs6428561 chr1:90102619 G/A cg21401794 chr1:90099060 LRRC8C 0.7 9.42 0.5 2.35e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs4237845 0.735 rs11172375 chr12:58291574 G/C cg04478727 chr12:58166393 METTL1;FAM119B 0.47 5.19 0.3 4.24e-7 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg11494091 chr17:61959527 GH2 0.66 10.9 0.56 4.09e-23 Prudent dietary pattern; CESC cis rs12200560 0.505 rs211183 chr6:97074723 G/T cg06623918 chr6:96969491 KIAA0776 -0.41 -5.44 -0.32 1.24e-7 Coronary heart disease; CESC trans rs591166 0.935 rs574988 chr18:57813648 G/C cg05268347 chr19:41218064 ADCK4 -0.4 -6.42 -0.37 6.44e-10 Body mass index; CESC cis rs9303280 0.901 rs8067378 chr17:38051348 A/G cg20243544 chr17:37824526 PNMT 0.52 7.07 0.4 1.36e-11 Self-reported allergy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04783338 chr16:23160430 USP31 0.53 6.03 0.35 5.52e-9 Gut microbiome composition (summer); CESC cis rs9549367 0.789 rs34448227 chr13:113884754 A/C cg00898013 chr13:113819073 PROZ -0.5 -6.82 -0.39 6.03e-11 Platelet distribution width; CESC cis rs2279817 0.863 rs11203441 chr1:18026725 C/T cg21791023 chr1:18019539 ARHGEF10L 0.55 8.06 0.44 2.71e-14 Neuroticism; CESC cis rs7940866 0.804 rs3910267 chr11:130810282 C/T cg12179176 chr11:130786555 SNX19 0.67 10.33 0.54 2.97e-21 Schizophrenia; CESC cis rs4561483 0.801 rs33619 chr16:12008941 T/G cg08843971 chr16:11963173 GSPT1 -0.54 -7.95 -0.44 5.3e-14 Testicular germ cell tumor; CESC cis rs796364 0.715 rs1106399 chr2:201003837 A/C cg23649088 chr2:200775458 C2orf69 -0.58 -5.71 -0.33 3.07e-8 Schizophrenia; CESC cis rs7264396 0.676 rs58372200 chr20:34555445 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.29 -0.53 4.22e-21 Total cholesterol levels; CESC cis rs1322639 0.614 rs9364356 chr6:169567108 G/A cg04662567 chr6:169592167 NA -0.51 -5.1 -0.3 6.59e-7 Pulse pressure; CESC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg05863683 chr7:1912471 MAD1L1 0.36 5.39 0.31 1.54e-7 Bipolar disorder and schizophrenia; CESC cis rs35110281 0.667 rs9941787 chr21:45116042 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -8.67 -0.47 4.28e-16 Mean corpuscular volume; CESC cis rs7833986 0.501 rs72653951 chr8:56961837 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.6 7.34 0.41 2.58e-12 Height; CESC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg24846343 chr22:24311635 DDTL -0.43 -5.6 -0.33 5.4e-8 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg11663144 chr21:46675770 NA -0.51 -7.1 -0.4 1.14e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg18252515 chr7:66147081 NA 0.39 5.18 0.3 4.4e-7 Aortic root size; CESC cis rs57221529 0.655 rs11948381 chr5:568413 A/T cg16447950 chr5:562315 NA -0.67 -7.85 -0.43 1.03e-13 Lung disease severity in cystic fibrosis; CESC cis rs67478160 0.643 rs34813623 chr14:104263294 A/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.82 0.55 7.82e-23 Schizophrenia; CESC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.79 0.39 7.21e-11 Depression; CESC cis rs2204008 0.748 rs11514352 chr12:38246954 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.3 0.36 1.24e-9 Bladder cancer; CESC trans rs9929218 0.529 rs11075694 chr16:68730366 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.88 14.6 0.67 8.08e-36 Colorectal cancer; CESC cis rs3791556 0.842 rs55840142 chr2:240106884 G/A cg03281426 chr2:240109471 HDAC4 0.54 6.95 0.39 2.81e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9715521 0.868 rs62301181 chr4:59834246 A/G cg11281224 chr4:60001000 NA -0.51 -6.74 -0.38 9.64e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7605827 0.930 rs2287263 chr2:15637366 C/T cg19274914 chr2:15703543 NA 0.31 5.46 0.32 1.08e-7 Educational attainment (years of education); CESC trans rs3780486 0.505 rs10813959 chr9:33166234 C/T cg04842962 chr6:43655489 MRPS18A -0.67 -10.2 -0.53 8.02e-21 IgG glycosylation; CESC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg16325326 chr1:53192061 ZYG11B -0.98 -17.51 -0.73 3.83e-46 Monocyte count; CESC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg04282206 chr17:62833786 PLEKHM1P 0.57 6.57 0.37 2.6e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg17971929 chr21:40555470 PSMG1 1.07 16.37 0.71 4.17e-42 Cognitive function; CESC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg17372223 chr3:52568218 NT5DC2 0.42 6.33 0.36 1.05e-9 Electroencephalogram traits; CESC cis rs1691799 0.899 rs1168302 chr12:66737518 C/T cg16791601 chr12:66731901 HELB -0.78 -14.03 -0.65 8.41e-34 White blood cell count (basophil); CESC cis rs6499129 1.000 rs9933206 chr16:67539022 C/T cg26727032 chr16:67993705 SLC12A4 0.52 5.66 0.33 3.97e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs66731853 0.769 rs477679 chr1:20894618 A/G cg04087271 chr1:20915334 CDA 0.56 7.27 0.41 4.03e-12 Mean corpuscular volume; CESC cis rs6783573 0.535 rs12637699 chr3:46628443 C/T cg21489266 chr3:46619131 LRRC2;TDGF1 -0.46 -6.76 -0.38 8.99e-11 Cerebrospinal fluid biomarker levels; CESC cis rs3008870 0.755 rs2815366 chr1:67499930 C/T cg02640540 chr1:67518911 SLC35D1 0.46 5.64 0.33 4.33e-8 Lymphocyte percentage of white cells; CESC cis rs7589342 0.501 rs12995849 chr2:106443111 C/T cg16077055 chr2:106428750 NCK2 0.4 6.17 0.35 2.56e-9 Addiction; CESC cis rs6740322 0.895 rs6744746 chr2:43555805 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.61 6.68 0.38 1.44e-10 Coronary artery disease; CESC cis rs644148 0.933 rs565819 chr19:44967714 A/G cg15540054 chr19:45004280 ZNF180 0.71 8.73 0.47 2.89e-16 Personality dimensions; CESC cis rs2228479 0.850 rs74251570 chr16:89910068 C/A cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs593982 1.000 rs118030231 chr11:65501905 G/A cg08755490 chr11:65554678 OVOL1 -1.27 -10.6 -0.55 3.99e-22 Atopic dermatitis; CESC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.78 9.43 0.5 2.15e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg07507251 chr3:52567010 NT5DC2 0.4 7.1 0.4 1.15e-11 Bipolar disorder; CESC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg23758822 chr17:41437982 NA 1.03 15.5 0.69 5.3e-39 Menopause (age at onset); CESC cis rs826838 1.000 rs10875717 chr12:38911174 T/C cg13010199 chr12:38710504 ALG10B 0.6 8.42 0.46 2.38e-15 Heart rate; CESC cis rs9522267 0.535 rs9522304 chr13:112237316 C/T cg10483660 chr13:112241077 NA -0.33 -5.78 -0.33 2.14e-8 Hepatitis; CESC cis rs1878931 0.597 rs2680221 chr16:3462595 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.76 -9.04 -0.49 3.5e-17 Body mass index (adult); CESC cis rs7116495 1.000 rs2511114 chr11:71792147 T/C cg26138937 chr11:71823887 C11orf51 -0.87 -7.07 -0.4 1.36e-11 Severe influenza A (H1N1) infection; CESC cis rs2425143 1.000 rs45595739 chr20:34320759 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.3 0.31 2.46e-7 Blood protein levels; CESC cis rs2952156 1.000 rs2088126 chr17:37879030 A/G cg20243544 chr17:37824526 PNMT 0.63 7.66 0.43 3.41e-13 Asthma; CESC cis rs3126085 0.867 rs12027899 chr1:152253954 C/A cg03465714 chr1:152285911 FLG -0.45 -5.51 -0.32 8.65e-8 Atopic dermatitis; CESC cis rs68170813 0.559 rs12536574 chr7:106810997 A/T cg02696742 chr7:106810147 HBP1 -0.54 -5.13 -0.3 5.7e-7 Coronary artery disease; CESC trans rs6054906 0.710 rs6117744 chr20:7265038 A/C cg09175718 chr10:97453958 TCTN3 0.42 6.23 0.36 1.84e-9 Response to amphetamines; CESC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg26850624 chr5:429559 AHRR -0.48 -6.63 -0.38 1.85e-10 Cystic fibrosis severity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05481041 chr18:72922694 ZADH2;TSHZ1 0.45 6.12 0.35 3.4e-9 Gut microbiota (bacterial taxa); CESC cis rs950776 0.518 rs12916999 chr15:78826912 C/T cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs2108225 0.934 rs2190392 chr7:107452685 T/C cg18560240 chr7:107437656 SLC26A3 -0.4 -5.28 -0.31 2.66e-7 Ulcerative colitis; CESC cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg21475434 chr5:93447410 FAM172A 0.78 7.07 0.4 1.36e-11 Diabetic retinopathy; CESC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg15369054 chr17:80825471 TBCD -0.5 -7.12 -0.4 1.04e-11 Breast cancer; CESC cis rs7582720 1.000 rs72932574 chr2:203866336 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs17253792 0.822 rs78143160 chr14:56150097 A/G cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs9611565 0.512 rs45500192 chr22:42177899 A/G cg17376030 chr22:41985996 PMM1 0.78 8.14 0.45 1.57e-14 Vitiligo; CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg18337363 chr3:52569053 NT5DC2 0.29 5.36 0.31 1.82e-7 Electroencephalogram traits; CESC cis rs9814567 0.896 rs10935123 chr3:134345327 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.67 -0.33 3.63e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg01017244 chr2:74357527 NA 0.68 9.87 0.52 8.77e-20 Gestational age at birth (maternal effect); CESC cis rs854765 0.583 rs8078583 chr17:17811465 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.23 0.36 1.85e-9 Total body bone mineral density; CESC cis rs12541635 0.677 rs1603357 chr8:107000565 G/C cg10147462 chr8:107024639 NA 0.44 6.55 0.37 3.01e-10 Age of smoking initiation; CESC cis rs3736485 0.966 rs8041514 chr15:51866054 T/C cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg09031165 chr17:17586474 RAI1 -0.49 -6.46 -0.37 5.04e-10 Height; CESC cis rs2066819 0.892 rs75274818 chr12:56627619 A/G cg26734620 chr12:56694298 CS 1.02 6.33 0.36 1.03e-9 Psoriasis vulgaris; CESC cis rs6088580 0.634 rs3746455 chr20:32957216 G/A cg08999081 chr20:33150536 PIGU -0.65 -11.49 -0.58 4.77e-25 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.15e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg24308560 chr3:49941425 MST1R 0.61 8.83 0.48 1.49e-16 Intelligence (multi-trait analysis); CESC cis rs2985684 1.000 rs2985684 chr14:50101682 C/G cg15316458 chr14:50087796 RPL36AL;MGAT2 0.45 5.15 0.3 4.99e-7 Carotid intima media thickness; CESC trans rs1814175 0.645 rs2140602 chr11:50022800 G/C cg15704280 chr7:45808275 SEPT13 -1.0 -18.54 -0.75 9.01e-50 Height; CESC cis rs2073300 0.609 rs56334525 chr20:23365812 A/G cg12062639 chr20:23401060 NAPB 1.06 8.37 0.46 3.42e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23697400 chr5:64064613 SDCCAG10;SFRS12IP1 0.45 6.24 0.36 1.72e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9291683 0.546 rs12504565 chr4:10045145 G/A cg11266682 chr4:10021025 SLC2A9 0.65 12.28 0.6 9.55e-28 Bone mineral density; CESC cis rs2576037 0.526 rs564113 chr18:44364389 A/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.12 0.3 5.75e-7 Personality dimensions; CESC cis rs7267979 1.000 rs3002702 chr20:25268920 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.88 18.33 0.75 4.99e-49 Liver enzyme levels (alkaline phosphatase); CESC cis rs1865760 0.566 rs1800702 chr6:26086463 C/G cg16482183 chr6:26056742 HIST1H1C 0.38 5.11 0.3 6.19e-7 Height; CESC cis rs7223966 0.921 rs7225092 chr17:61864005 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.63 0.38 1.85e-10 Hip circumference adjusted for BMI;Body mass index; CESC trans rs6089829 0.962 rs3746749 chr20:61667333 T/C cg23505145 chr19:12996616 KLF1 0.51 6.68 0.38 1.37e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs10242455 0.702 rs73713531 chr7:99222379 C/T cg09045935 chr12:6379348 NA 0.83 6.29 0.36 1.32e-9 Blood metabolite levels; CESC cis rs6432018 1.000 rs7569485 chr2:9738774 C/T cg23886495 chr2:9695866 ADAM17 0.43 5.2 0.3 3.93e-7 Heart rate variability traits; CESC trans rs634534 0.563 rs470192 chr11:65724291 C/T cg17712092 chr4:129076599 LARP1B 0.7 9.65 0.51 4.53e-19 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs10504229 0.679 rs60869047 chr8:58053221 G/A cg22535103 chr8:58192502 C8orf71 -0.65 -7.25 -0.41 4.69e-12 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg06873352 chr17:61820015 STRADA 0.69 11.99 0.59 9.76e-27 Prudent dietary pattern; CESC trans rs208520 1.000 rs72884025 chr6:66994185 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.14 0.49 1.65e-17 Exhaled nitric oxide output; CESC cis rs6991838 0.584 rs4737221 chr8:66481310 G/A cg13398993 chr8:66546079 ARMC1 -0.45 -5.45 -0.32 1.16e-7 Intelligence (multi-trait analysis); CESC trans rs367943 1.000 rs348961 chr5:112819944 A/C cg06453915 chr11:62538484 TAF6L -0.56 -6.08 -0.35 4.18e-9 Type 2 diabetes; CESC cis rs644799 1.000 rs509720 chr11:95562771 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.76 0.38 8.51e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9467711 0.516 rs523383 chr6:25869848 A/G cg08501292 chr6:25962987 TRIM38 0.55 5.96 0.34 7.97e-9 Autism spectrum disorder or schizophrenia; CESC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.63 -8.04 -0.44 3.09e-14 Tonsillectomy; CESC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg06577658 chr19:46296270 DMWD 0.43 5.17 0.3 4.55e-7 Coronary artery disease; CESC cis rs11853189 0.938 rs77185764 chr15:78556076 G/A cg22935921 chr15:78556834 DNAJA4 0.63 5.27 0.31 2.88e-7 Red cell distribution width; CESC cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg05863683 chr7:1912471 MAD1L1 0.43 6.59 0.38 2.42e-10 Bipolar disorder and schizophrenia; CESC cis rs6466055 0.611 rs3213742 chr7:104643230 C/A cg04380332 chr7:105027541 SRPK2 -0.38 -5.46 -0.32 1.12e-7 Schizophrenia; CESC trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21659725 chr3:3221576 CRBN 0.83 13.44 0.64 9.18e-32 Intelligence (multi-trait analysis); CESC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg00409905 chr10:38381863 ZNF37A -0.52 -7.09 -0.4 1.22e-11 Extrinsic epigenetic age acceleration; CESC cis rs959260 1.000 rs4789184 chr17:73383314 A/G cg20590849 chr17:73267439 MIF4GD -0.57 -6.73 -0.38 1.07e-10 Systemic lupus erythematosus; CESC cis rs763014 0.898 rs916414 chr16:632073 C/T cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC cis rs4555082 0.789 rs2816649 chr14:105708326 A/G cg13114125 chr14:105738426 BRF1 -0.67 -8.35 -0.46 3.79e-15 Mean platelet volume;Platelet distribution width; CESC trans rs116095464 0.558 rs62344345 chr5:257420 C/T cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.35e-11 Breast cancer; CESC trans rs10421328 0.950 rs55831814 chr19:19777644 C/T cg10278149 chr2:208016923 KLF7 0.51 6.11 0.35 3.62e-9 Parental longevity (combined parental age at death); CESC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg12648201 chr2:27665141 KRTCAP3 -0.31 -5.65 -0.33 4.22e-8 Total body bone mineral density; CESC cis rs6446731 0.517 rs2071668 chr4:3269905 A/G cg08886695 chr4:3369023 RGS12 0.39 5.67 0.33 3.69e-8 Mean platelet volume; CESC cis rs2732480 0.557 rs2409004 chr12:48721451 T/C cg24011408 chr12:48396354 COL2A1 0.4 5.76 0.33 2.31e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05522046 chr3:52931664 TMEM110 0.5 6.39 0.37 7.53e-10 Gut microbiota (bacterial taxa); CESC cis rs7395581 0.959 rs326222 chr11:47259668 A/G cg25783544 chr11:47291846 MADD -0.53 -6.86 -0.39 4.72e-11 HDL cholesterol; CESC cis rs6088580 0.601 rs6120668 chr20:33099793 A/G cg08999081 chr20:33150536 PIGU 0.65 11.26 0.57 2.65e-24 Glomerular filtration rate (creatinine); CESC cis rs3008870 1.000 rs3008871 chr1:67419089 A/G cg02640540 chr1:67518911 SLC35D1 -0.52 -5.6 -0.33 5.4e-8 Lymphocyte percentage of white cells; CESC cis rs962856 0.633 rs6755775 chr2:67598583 G/C cg09028215 chr2:67624308 ETAA1 -0.41 -5.42 -0.32 1.33e-7 Pancreatic cancer; CESC trans rs3780486 0.846 rs913214 chr9:33135085 G/A cg04842962 chr6:43655489 MRPS18A 1.0 19.06 0.76 1.32e-51 IgG glycosylation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24513045 chr20:62711519 RGS19;OPRL1 -0.47 -6.86 -0.39 4.96e-11 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04151384 chr11:10315732 SBF2 0.64 6.88 0.39 4.29e-11 Gut microbiome composition (summer); CESC trans rs11098499 0.731 rs6846966 chr4:120293208 A/G cg25214090 chr10:38739885 LOC399744 0.66 9.15 0.49 1.54e-17 Corneal astigmatism; CESC cis rs4888262 0.526 rs7193508 chr16:74628630 G/T cg01733217 chr16:74700730 RFWD3 0.86 11.88 0.59 2.16e-26 Testicular germ cell tumor; CESC cis rs3733585 0.605 rs4235354 chr4:10122942 C/A cg00071950 chr4:10020882 SLC2A9 -0.65 -9.64 -0.51 4.77e-19 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg20476274 chr7:133979776 SLC35B4 0.63 8.81 0.48 1.7e-16 Mean platelet volume; CESC cis rs7267979 1.000 rs4815420 chr20:25383979 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.41 -0.32 1.4e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs4727027 0.901 rs1137432 chr7:148801658 C/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.89 -0.39 4.11e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2996428 0.561 rs12134919 chr1:3744641 G/A cg13057898 chr1:3703894 LRRC47 0.38 5.66 0.33 3.84e-8 Red cell distribution width; CESC cis rs9814567 1.000 rs6787371 chr3:134254991 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.97 -0.34 7.51e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs8077889 0.917 rs60335331 chr17:41907509 A/G cg26893861 chr17:41843967 DUSP3 0.77 10.29 0.53 4.25e-21 Triglycerides; CESC cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg14784868 chr12:69753453 YEATS4 0.84 13.21 0.63 6.15e-31 Blood protein levels; CESC cis rs17666538 0.585 rs336444 chr8:633123 C/G cg07234876 chr8:600039 NA -0.66 -5.7 -0.33 3.2e-8 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16594066 chr16:30569726 ZNF764 0.56 6.73 0.38 1.04e-10 Gut microbiome composition (summer); CESC cis rs8078723 0.966 rs57065891 chr17:38168227 C/T cg17467752 chr17:38218738 THRA 0.67 10.03 0.52 2.9e-20 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs1559088 0.948 rs10410778 chr19:33592301 C/A cg17764715 chr19:33622953 WDR88 0.49 6.32 0.36 1.11e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.18e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.49 -6.41 -0.37 6.59e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs826838 1.000 rs9795768 chr12:39012479 T/C cg26384229 chr12:38710491 ALG10B 0.8 13.91 0.65 2.13e-33 Heart rate; CESC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg07870213 chr5:140052090 DND1 -0.61 -6.87 -0.39 4.47e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg21573476 chr21:45109991 RRP1B -0.46 -6.49 -0.37 4.16e-10 Mean corpuscular volume; CESC trans rs11039798 0.588 rs643668 chr11:48413399 C/G cg15704280 chr7:45808275 SEPT13 -0.63 -6.3 -0.36 1.22e-9 Axial length; CESC cis rs8016982 0.633 rs9944085 chr14:81717620 A/T cg01989461 chr14:81687754 GTF2A1 -0.72 -11.35 -0.57 1.37e-24 Schizophrenia; CESC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg06634786 chr22:41940651 POLR3H 0.68 6.62 0.38 1.94e-10 Vitiligo; CESC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC cis rs616402 0.527 rs11584327 chr1:10578791 T/C cg20482658 chr1:10539492 PEX14 -0.28 -5.9 -0.34 1.11e-8 Breast size; CESC cis rs2652822 0.530 rs7165016 chr15:63439590 T/A cg02713581 chr15:63449717 RPS27L 0.48 5.46 0.32 1.08e-7 Metabolic traits; CESC trans rs66573146 0.831 rs6832482 chr4:7023433 A/T cg07817883 chr1:32538562 TMEM39B 0.95 6.14 0.35 3.07e-9 Granulocyte percentage of myeloid white cells; CESC cis rs2439831 1.000 rs2444029 chr15:43737484 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.81 11.86 0.59 2.71e-26 Lung cancer in ever smokers; CESC trans rs11098499 0.874 rs13139045 chr4:120168588 T/C cg25214090 chr10:38739885 LOC399744 0.61 8.16 0.45 1.34e-14 Corneal astigmatism; CESC cis rs2832191 0.791 rs2065270 chr21:30485420 T/C cg24692254 chr21:30365293 RNF160 -0.79 -12.51 -0.61 1.62e-28 Dental caries; CESC trans rs11971186 0.765 rs1204526 chr7:126512514 C/T cg10894441 chr11:111169905 C11orf92;C11orf93 -0.49 -6.26 -0.36 1.51e-9 Chemerin levels; CESC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg17724175 chr1:150552817 MCL1 0.42 6.43 0.37 5.8e-10 Melanoma; CESC cis rs1511802 0.666 rs2292424 chr4:187120625 G/A cg24794857 chr4:187113578 CYP4V2 0.43 5.55 0.32 6.87e-8 Blood protein levels; CESC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg19592336 chr6:28129416 ZNF389 0.55 7.35 0.41 2.39e-12 Parkinson's disease; CESC cis rs2569991 0.541 rs2596905 chr3:12937672 A/C cg22481960 chr3:13008800 IQSEC1 -0.55 -6.52 -0.37 3.47e-10 Periodontitis (DPAL); CESC cis rs6750795 0.569 rs1667308 chr2:232406344 T/C cg19187155 chr2:232395269 NMUR1 0.63 11.18 0.57 5.03e-24 Height; CESC cis rs71277158 0.688 rs73879182 chr3:169879695 C/T cg04067573 chr3:169899625 PHC3 0.71 7.07 0.4 1.39e-11 Prostate cancer; CESC cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg09658497 chr7:2847517 GNA12 -0.36 -5.51 -0.32 8.41e-8 Height; CESC cis rs7772486 0.875 rs6938972 chr6:146410608 G/A cg05347473 chr6:146136440 FBXO30 0.51 6.68 0.38 1.37e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04342999 chr5:138629163 MATR3 0.48 6.49 0.37 4.13e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs66887589 0.967 rs1480933 chr4:120433248 C/T cg09307838 chr4:120376055 NA 0.49 6.49 0.37 4.28e-10 Diastolic blood pressure; CESC cis rs9815354 1.000 rs9866092 chr3:41895967 A/C cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.48e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs9611565 0.546 rs5758430 chr22:42109844 G/T cg06634786 chr22:41940651 POLR3H 0.66 6.76 0.38 8.7e-11 Vitiligo; CESC cis rs7188697 0.882 rs9921370 chr16:58611935 C/A cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs7833986 0.501 rs2668007 chr8:56944111 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.54 6.23 0.36 1.79e-9 Height; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg04914231 chr16:30006637 INO80E;HIRIP3 0.45 6.08 0.35 4.2e-9 Breast cancer;Type 2 diabetes; CESC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg21782813 chr7:2030301 MAD1L1 0.37 5.19 0.3 4.19e-7 Bipolar disorder and schizophrenia; CESC cis rs9911578 0.935 rs12948039 chr17:57045184 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.37 5.05 0.3 8.18e-7 Intelligence (multi-trait analysis); CESC cis rs6460942 0.730 rs73053536 chr7:12323131 C/G cg02935154 chr7:12443704 VWDE -0.6 -5.72 -0.33 2.83e-8 Coronary artery disease; CESC cis rs8072100 0.840 rs12453233 chr17:45454570 C/T cg25173405 chr17:45401733 C17orf57 -0.43 -5.64 -0.33 4.46e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg21770322 chr7:97807741 LMTK2 0.57 8.72 0.47 3.09e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs7208859 0.623 rs216423 chr17:28942109 G/C cg17105886 chr17:28927953 LRRC37B2 0.62 5.61 0.33 5.18e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7116495 1.000 rs1939247 chr11:71740521 A/T cg26138937 chr11:71823887 C11orf51 -0.79 -6.43 -0.37 5.96e-10 Severe influenza A (H1N1) infection; CESC cis rs6500602 0.727 rs4786509 chr16:4568769 C/G cg08645402 chr16:4508243 NA -0.57 -9.43 -0.5 2.18e-18 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06825833 chr13:111566802 ANKRD10 -0.48 -6.87 -0.39 4.58e-11 Gambling; CESC cis rs2228479 1.000 rs11642267 chr16:89957635 T/C cg00800038 chr16:89945340 TCF25 -0.94 -7.87 -0.44 9.24e-14 Skin colour saturation; CESC cis rs6565180 1.000 rs8049108 chr16:30376486 A/G cg17640201 chr16:30407289 ZNF48 -0.87 -14.27 -0.66 1.11e-34 Tonsillectomy; CESC cis rs12579753 0.879 rs7131927 chr12:82166313 T/C cg24719984 chr12:82153464 PPFIA2 -0.37 -5.35 -0.31 1.9e-7 Resting heart rate; CESC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg10691866 chr7:65817282 TPST1 0.34 5.54 0.32 7.19e-8 Aortic root size; CESC cis rs8027181 0.839 rs998020 chr15:72999635 C/T cg25632853 chr15:73088954 NA 0.29 5.05 0.3 8.32e-7 Triglyceride levels; CESC cis rs6460942 1.000 rs73053531 chr7:12317474 T/C cg20607287 chr7:12443886 VWDE -0.79 -8.51 -0.46 1.32e-15 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17114200 chr7:4822807 KIAA0415 0.49 7.11 0.4 1.09e-11 Fibrinogen levels; CESC cis rs2777491 0.789 rs316617 chr15:41795900 C/T cg20272979 chr15:41787780 ITPKA -0.47 -6.92 -0.39 3.38e-11 Ulcerative colitis; CESC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg18446336 chr7:2847575 GNA12 -0.35 -5.56 -0.32 6.7e-8 Height; CESC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 8.16 0.45 1.36e-14 Bipolar disorder; CESC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg17747265 chr1:1875780 NA -0.57 -9.25 -0.49 7.79e-18 Body mass index; CESC cis rs17253792 0.822 rs9972180 chr14:56073732 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs4728302 0.869 rs6969899 chr7:133597490 A/G cg10665199 chr7:133106180 EXOC4 0.41 5.71 0.33 3.03e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs74181299 0.964 rs1009358 chr2:65276452 C/T cg05010058 chr2:65284262 CEP68 -0.3 -5.28 -0.31 2.74e-7 Pulse pressure; CESC cis rs2075671 0.903 rs62483570 chr7:100300649 C/T cg16850897 chr7:100343110 ZAN -0.7 -8.74 -0.47 2.7e-16 Other erythrocyte phenotypes; CESC cis rs1538970 1.000 rs4660852 chr1:45848931 A/C cg03146154 chr1:46216737 IPP -0.45 -5.48 -0.32 1.01e-7 Platelet count; CESC cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg03433033 chr1:76189801 ACADM 0.57 5.57 0.32 6.26e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11203032 1.000 rs17117124 chr10:90963997 C/G cg16672925 chr10:90967113 CH25H 0.74 7.11 0.4 1.05e-11 Heart failure; CESC cis rs9858542 0.953 rs3811697 chr3:49590770 C/T cg07274523 chr3:49395745 GPX1 0.66 8.52 0.46 1.21e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs3818285 0.504 rs1973972 chr10:111651133 A/T cg00817464 chr10:111662876 XPNPEP1 0.52 7.29 0.41 3.51e-12 Superior crus of antihelix expression; CESC cis rs1691799 0.899 rs1168358 chr12:66748664 A/G cg16791601 chr12:66731901 HELB -0.62 -10.14 -0.53 1.22e-20 White blood cell count (basophil); CESC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg20243544 chr17:37824526 PNMT -0.49 -6.24 -0.36 1.75e-9 Glomerular filtration rate (creatinine); CESC cis rs116095464 0.614 rs10061564 chr5:271329 T/C cg10591111 chr5:226296 SDHA -0.53 -6.39 -0.37 7.44e-10 Breast cancer; CESC cis rs6540559 0.546 rs7551944 chr1:210029430 G/C cg23283495 chr1:209979779 IRF6 0.5 5.08 0.3 6.99e-7 Cleft lip with or without cleft palate; CESC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg23161317 chr6:28129485 ZNF389 -0.41 -5.39 -0.31 1.58e-7 Depression; CESC cis rs16854884 0.657 rs35085196 chr3:143712210 C/T cg01302019 chr3:143689584 C3orf58 -0.34 -5.19 -0.3 4.14e-7 Economic and political preferences (feminism/equality); CESC cis rs1707322 1.000 rs4641257 chr1:46353589 G/A cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg11890956 chr21:40555474 PSMG1 1.18 23.93 0.83 3.5e-68 Cognitive function; CESC cis rs6430585 0.528 rs309154 chr2:136726567 C/T cg07169764 chr2:136633963 MCM6 1.13 15.63 0.69 1.78e-39 Corneal structure; CESC cis rs2130392 1.000 rs2130392 chr4:185639169 A/G cg21366198 chr4:185655624 MLF1IP -0.41 -6.0 -0.35 6.55e-9 Kawasaki disease; CESC cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg06697600 chr4:7070879 GRPEL1 0.51 6.11 0.35 3.49e-9 Monocyte percentage of white cells; CESC cis rs1577917 0.958 rs13201730 chr6:86556647 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.14 -0.35 2.93e-9 Response to antipsychotic treatment; CESC cis rs6598955 0.671 rs12139514 chr1:26575939 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg26839252 chr6:160211577 TCP1;MRPL18 0.44 5.05 0.3 8.32e-7 Age-related macular degeneration (geographic atrophy); CESC trans rs2727020 0.619 rs1829979 chr11:49436875 T/G cg03929089 chr4:120376271 NA -0.68 -7.62 -0.42 4.63e-13 Coronary artery disease; CESC trans rs11264799 0.716 rs1113662 chr1:157635825 T/C cg22691776 chr3:15032403 NR2C2 0.33 6.21 0.36 2e-9 IgA nephropathy; CESC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg12463550 chr7:65579703 CRCP -0.54 -6.94 -0.39 2.92e-11 Aortic root size; CESC cis rs6750795 0.765 rs6742387 chr2:232354832 G/T cg19187155 chr2:232395269 NMUR1 0.62 10.27 0.53 4.87e-21 Height; CESC cis rs2279817 1.000 rs10788681 chr1:18019524 C/A cg21791023 chr1:18019539 ARHGEF10L 0.58 8.5 0.46 1.36e-15 Neuroticism; CESC cis rs1048238 0.506 rs10927867 chr1:16177285 A/G cg21385522 chr1:16154831 NA 0.43 5.41 0.32 1.4e-7 Systolic blood pressure; CESC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg11987759 chr7:65425863 GUSB 0.46 6.29 0.36 1.29e-9 Aortic root size; CESC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg00149659 chr3:10157352 C3orf10 0.71 8.29 0.45 5.55e-15 Alzheimer's disease; CESC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg02187348 chr16:89574699 SPG7 0.63 8.85 0.48 1.25e-16 Multiple myeloma (IgH translocation); CESC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.07 0.6 5.1e-27 Alzheimer's disease; CESC cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg25019033 chr10:957182 NA -0.65 -6.53 -0.37 3.33e-10 Eosinophil percentage of granulocytes; CESC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg20243544 chr17:37824526 PNMT 0.45 5.94 0.34 8.69e-9 Glomerular filtration rate (creatinine); CESC trans rs61931739 0.500 rs11053210 chr12:34461771 A/G cg26384229 chr12:38710491 ALG10B -0.73 -10.18 -0.53 9.44e-21 Morning vs. evening chronotype; CESC cis rs3135071 1.000 rs3135071 chr4:2406321 C/T cg01601518 chr4:2404284 ZFYVE28 0.63 5.83 0.34 1.61e-8 Influenza A (H1N1) severity; CESC cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.7 -0.43 2.64e-13 Alzheimer's disease; CESC cis rs826838 0.935 rs11183940 chr12:38851642 A/G cg13010199 chr12:38710504 ALG10B 0.6 8.53 0.46 1.18e-15 Heart rate; CESC cis rs7255436 0.830 rs4350678 chr19:8447366 A/G cg16745616 chr19:8428856 ANGPTL4 -0.37 -5.54 -0.32 7.2e-8 HDL cholesterol; CESC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg11764359 chr7:65958608 NA 0.98 15.78 0.7 5.36e-40 Aortic root size; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg09509183 chr1:209979624 IRF6 0.62 9.72 0.51 2.61e-19 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs763121 0.925 rs1056661 chr22:39080245 A/G cg14440974 chr22:39074834 NA -0.35 -5.09 -0.3 6.78e-7 Menopause (age at onset); CESC cis rs826838 0.935 rs11168761 chr12:38997211 C/A cg26384229 chr12:38710491 ALG10B 0.83 14.62 0.67 6.88e-36 Heart rate; CESC cis rs2276314 0.857 rs28379448 chr18:33604364 C/A cg19628046 chr18:33552617 C18orf21 0.49 5.33 0.31 2.11e-7 Endometriosis;Drug-induced torsades de pointes; CESC cis rs6912958 0.754 rs7762864 chr6:88236213 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -7.43 -0.42 1.46e-12 Monocyte percentage of white cells; CESC cis rs17253792 0.822 rs118027213 chr14:56039076 T/C cg01858014 chr14:56050164 KTN1 -0.99 -7.46 -0.42 1.21e-12 Putamen volume; CESC cis rs2735413 0.781 rs11649473 chr16:78077238 C/T cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs300703 0.654 rs300771 chr2:117241 A/G cg21211680 chr2:198530 NA -0.99 -10.25 -0.53 5.38e-21 Blood protein levels; CESC cis rs7772486 0.790 rs1062068 chr6:146207465 A/G cg05347473 chr6:146136440 FBXO30 0.57 7.32 0.41 2.93e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7129220 0.512 rs11042666 chr11:10227393 A/T cg01453529 chr11:10209919 SBF2 -0.46 -5.63 -0.33 4.63e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg24531977 chr5:56204891 C5orf35 -0.87 -11.09 -0.56 9.93e-24 Initial pursuit acceleration; CESC trans rs7246657 0.943 rs8109632 chr19:37931125 A/T cg01833234 chr11:6592585 DNHD1 0.52 6.0 0.35 6.5e-9 Coronary artery calcification; CESC cis rs11958404 0.932 rs72816585 chr5:157433901 A/C cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg03806693 chr22:41940476 POLR3H 1.13 13.53 0.64 4.53e-32 Vitiligo; CESC cis rs4725617 0.686 rs4283960 chr7:143103380 C/T cg03150622 chr7:143105826 EPHA1 0.63 5.44 0.32 1.21e-7 Blood protein levels; CESC cis rs34779708 0.966 rs4934540 chr10:35474699 T/C cg04310649 chr10:35416472 CREM -0.52 -6.38 -0.37 7.67e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs9790314 1.000 rs9870059 chr3:161017240 T/C cg03342759 chr3:160939853 NMD3 -0.44 -5.77 -0.33 2.15e-8 Morning vs. evening chronotype; CESC cis rs2228479 0.850 rs2238531 chr16:89856217 C/G cg00800038 chr16:89945340 TCF25 -0.9 -7.5 -0.42 9.55e-13 Skin colour saturation; CESC cis rs7666738 0.830 rs921521 chr4:98838339 A/G cg17366294 chr4:99064904 C4orf37 0.52 7.03 0.4 1.75e-11 Colonoscopy-negative controls vs population controls; CESC cis rs1348850 0.801 rs11890163 chr2:178327134 G/A cg23306229 chr2:178417860 TTC30B 0.72 6.02 0.35 5.72e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs55704346 0.566 rs7661300 chr4:25385874 T/C cg01822600 chr1:245751692 KIF26B 0.43 6.26 0.36 1.55e-9 Tonsillectomy; CESC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg13206674 chr6:150067644 NUP43 0.42 5.87 0.34 1.32e-8 Lung cancer; CESC cis rs4132509 1.000 rs4565696 chr1:243918083 C/T cg21452805 chr1:244014465 NA 0.45 5.6 0.33 5.43e-8 RR interval (heart rate); CESC cis rs2124969 0.548 rs62175391 chr2:161022588 A/G cg03641300 chr2:160917029 PLA2R1 -0.58 -6.01 -0.35 6.14e-9 Waist circumference adjusted for body mass index; CESC cis rs6831352 0.589 rs2924584 chr4:99988208 A/G cg12011299 chr4:100065546 ADH4 0.75 11.75 0.59 6.04e-26 Alcohol dependence; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17914881 chr12:121838395 RNF34 0.49 6.3 0.36 1.22e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs548181 0.736 rs540436 chr11:125512619 A/G cg03464685 chr11:125439445 EI24 0.9 7.62 0.42 4.55e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs3825932 0.961 rs11072815 chr15:79232319 C/T cg25744700 chr15:79237217 CTSH -0.48 -6.58 -0.37 2.48e-10 Type 1 diabetes; CESC cis rs734999 0.588 rs3748819 chr1:2524966 C/T cg20673091 chr1:2541236 MMEL1 0.43 7.01 0.4 1.97e-11 Ulcerative colitis; CESC cis rs727505 0.865 rs10253613 chr7:124508929 G/A cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs13088281 1.000 rs13088281 chr3:53147576 A/C cg12962167 chr3:53033115 SFMBT1 -0.66 -5.96 -0.34 8.08e-9 Immune reponse to smallpox (secreted IL-2); CESC trans rs3780486 0.522 rs1328898 chr9:33163271 A/G cg20290983 chr6:43655470 MRPS18A 0.73 11.48 0.58 5.05e-25 IgG glycosylation; CESC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg26338869 chr17:61819248 STRADA 0.66 8.55 0.46 1.02e-15 Prudent dietary pattern; CESC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg06808227 chr14:105710500 BRF1 -0.64 -7.65 -0.43 3.72e-13 Mean platelet volume;Platelet distribution width; CESC cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.64 7.51 0.42 9.22e-13 Multiple sclerosis; CESC cis rs7296418 0.630 rs11608305 chr12:123791165 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.14 -0.3 5.27e-7 Platelet count; CESC cis rs1691799 0.899 rs903590 chr12:66745777 C/G cg16791601 chr12:66731901 HELB -0.62 -10.31 -0.53 3.66e-21 White blood cell count (basophil); CESC cis rs1044826 0.642 rs295470 chr3:139213903 A/G cg15131784 chr3:139108705 COPB2 0.41 5.07 0.3 7.34e-7 Obesity-related traits; CESC cis rs11122272 0.735 rs973253 chr1:231520874 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05321656 chr10:69991522 ATOH7 -0.61 -7.29 -0.41 3.51e-12 Gut microbiome composition (summer); CESC cis rs9811920 0.609 rs793501 chr3:99591638 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15163603 chr12:132403897 ULK1 -0.51 -6.69 -0.38 1.3e-10 Gut microbiome composition (summer); CESC trans rs7922314 0.571 rs59286975 chr10:64736664 G/A cg06935979 chr1:232941706 KIAA1383 -0.69 -6.41 -0.37 6.71e-10 Cutaneous psoriasis; CESC cis rs9660992 0.710 rs1172111 chr1:205232980 C/T cg21643547 chr1:205240462 TMCC2 -0.48 -6.81 -0.39 6.59e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg18769074 chr3:133464867 TF 0.3 5.68 0.33 3.46e-8 Iron status biomarkers (transferrin levels); CESC cis rs9733 0.715 rs12402006 chr1:150869829 G/A cg18016565 chr1:150552671 MCL1 -0.33 -5.16 -0.3 4.95e-7 Tonsillectomy; CESC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.58 7.65 0.43 3.74e-13 Personality dimensions; CESC cis rs1577917 0.665 rs4304137 chr6:86217448 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.57 7.74 0.43 2.16e-13 Response to antipsychotic treatment; CESC cis rs6540556 0.954 rs6685077 chr1:209933331 A/G cg23920097 chr1:209922102 NA -0.37 -5.54 -0.32 7.2e-8 Red blood cell count; CESC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.76 -0.38 8.6e-11 Parkinson's disease; CESC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.51 -0.32 8.35e-8 Huntington's disease progression; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09058860 chr1:173837788 SNORD74;ZBTB37;GAS5 -0.45 -6.35 -0.36 9.46e-10 Asthma; CESC trans rs12286929 0.651 rs12274772 chr11:115098768 C/T cg20957193 chr16:75032774 ZNRF1 -0.55 -6.07 -0.35 4.46e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg09359103 chr1:154839909 KCNN3 0.67 13.48 0.64 6.75e-32 Prostate cancer; CESC cis rs2120019 1.000 rs2120019 chr15:75334184 T/C cg09165964 chr15:75287851 SCAMP5 -0.78 -9.31 -0.5 5.02e-18 Blood trace element (Zn levels); CESC cis rs7216064 0.700 rs4791295 chr17:65997317 G/A cg07042672 chr17:66097459 LOC651250 -0.5 -5.59 -0.32 5.67e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9325144 0.555 rs4882358 chr12:38726640 A/G cg26384229 chr12:38710491 ALG10B 0.56 7.99 0.44 4.24e-14 Morning vs. evening chronotype; CESC cis rs10911251 0.546 rs2147578 chr1:183107699 G/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.2 0.63 6.6e-31 Colorectal cancer; CESC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg11890956 chr21:40555474 PSMG1 -0.93 -14.73 -0.67 2.85e-36 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13150400 chr6:135819157 C6orf217;AHI1 0.55 6.31 0.36 1.15e-9 Gut microbiome composition (summer); CESC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg18337363 chr3:52569053 NT5DC2 0.29 5.28 0.31 2.66e-7 Electroencephalogram traits; CESC cis rs7246657 0.943 rs10415358 chr19:37808863 C/A cg23950597 chr19:37808831 NA -0.63 -6.45 -0.37 5.42e-10 Coronary artery calcification; CESC cis rs12477438 0.765 rs12470471 chr2:99689141 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.63 8.61 0.47 6.57e-16 Chronic sinus infection; CESC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.84 0.34 1.55e-8 Tonsillectomy; CESC cis rs6570726 0.935 rs419850 chr6:145827281 A/G cg23711669 chr6:146136114 FBXO30 0.79 11.77 0.59 5.16e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs3820068 0.705 rs41270255 chr1:15892980 G/A cg18192808 chr1:15853278 DNAJC16 0.43 5.17 0.3 4.6e-7 Systolic blood pressure; CESC cis rs73206853 0.764 rs67828368 chr12:110546298 C/T cg12870014 chr12:110450643 ANKRD13A 0.62 5.32 0.31 2.16e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs11051970 0.513 rs4931013 chr12:32560722 C/A cg24626660 chr12:32551988 NA 0.36 5.2 0.3 4.09e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1865760 0.566 rs9295686 chr6:26081983 G/C cg16482183 chr6:26056742 HIST1H1C 0.38 5.11 0.3 6.19e-7 Height; CESC cis rs8180040 0.522 rs749512 chr3:47035900 C/T cg27129171 chr3:47204927 SETD2 -0.66 -9.25 -0.49 7.9e-18 Colorectal cancer; CESC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg16325326 chr1:53192061 ZYG11B -0.88 -14.98 -0.68 3.69e-37 Monocyte count; CESC cis rs72781680 1.000 rs72796337 chr2:24142957 G/A cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs10214930 0.697 rs10256550 chr7:27906927 A/C cg05786569 chr7:27702416 HIBADH 0.46 5.43 0.32 1.3e-7 Hypospadias; CESC cis rs9354308 0.903 rs9360158 chr6:66558164 C/T cg07460842 chr6:66804631 NA -0.47 -5.72 -0.33 2.81e-8 Metabolite levels; CESC cis rs9914988 0.943 rs11651867 chr17:27147248 T/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg18225595 chr11:63971243 STIP1 0.53 5.51 0.32 8.36e-8 Mean platelet volume; CESC cis rs13031619 0.615 rs4849974 chr2:3698865 C/G cg19052272 chr2:3704530 ALLC 0.7 7.38 0.41 2.03e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17287814 chr8:26149013 PPP2R2A -0.46 -6.71 -0.38 1.2e-10 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14580081 chr19:45873861 ERCC2 0.58 7.0 0.4 2.11e-11 Gut microbiome composition (summer); CESC cis rs4595586 0.545 rs1303886 chr12:39366876 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg24250549 chr1:154909240 PMVK 0.74 11.09 0.56 1.01e-23 Prostate cancer; CESC cis rs1707322 0.821 rs10749857 chr1:46248143 C/T cg03146154 chr1:46216737 IPP 0.8 11.17 0.57 5.31e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2274273 0.837 rs8011329 chr14:55677255 G/A cg04306507 chr14:55594613 LGALS3 0.3 5.9 0.34 1.09e-8 Protein biomarker; CESC trans rs11098499 0.954 rs2389802 chr4:120325732 C/A cg25214090 chr10:38739885 LOC399744 0.7 9.93 0.52 5.65e-20 Corneal astigmatism; CESC cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg18512352 chr11:47633146 NA 0.53 7.86 0.43 9.6e-14 Subjective well-being; CESC cis rs28489187 0.683 rs11161607 chr1:85855855 T/C cg16011679 chr1:85725395 C1orf52 0.53 6.17 0.35 2.49e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11354908 chr19:18255899 MAST3 0.48 6.25 0.36 1.65e-9 Fibrinogen levels; CESC cis rs258892 0.842 rs10060065 chr5:72065830 T/C cg21869765 chr5:72125136 TNPO1 -0.43 -5.35 -0.31 1.93e-7 Small cell lung carcinoma; CESC cis rs7208859 0.623 rs73271872 chr17:29152228 C/G cg19761014 chr17:28927070 LRRC37B2 0.74 6.03 0.35 5.43e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg03060546 chr3:49711283 APEH 0.5 6.05 0.35 4.94e-9 Parkinson's disease; CESC cis rs7674212 0.539 rs6854709 chr4:104129786 A/G cg16532752 chr4:104119610 CENPE -0.4 -5.58 -0.32 6.05e-8 Type 2 diabetes; CESC cis rs10088262 0.591 rs13270541 chr8:124794849 G/A cg02993010 chr8:124780839 FAM91A1 -0.67 -8.55 -0.46 1.01e-15 Pancreatic cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02501984 chr12:133263946 POLE;PXMP2 0.56 6.72 0.38 1.08e-10 Gut microbiome composition (summer); CESC cis rs9894429 0.752 rs7502883 chr17:79588557 T/C cg21984481 chr17:79567631 NPLOC4 -0.58 -9.48 -0.5 1.5e-18 Eye color traits; CESC cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg05347473 chr6:146136440 FBXO30 -0.55 -7.07 -0.4 1.41e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs11051970 0.559 rs73086036 chr12:32564585 C/T cg24626660 chr12:32551988 NA 0.35 5.03 0.3 9.04e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg26408565 chr15:76604113 ETFA -0.43 -6.25 -0.36 1.65e-9 Blood metabolite levels; CESC cis rs4253772 0.530 rs11704350 chr22:46671507 C/T cg10541313 chr22:46663664 TTC38 0.71 5.29 0.31 2.56e-7 LDL cholesterol;Cholesterol, total; CESC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg21433313 chr16:3507492 NAT15 -0.5 -6.91 -0.39 3.68e-11 Tuberculosis; CESC cis rs6120849 0.708 rs6087659 chr20:33606383 C/A cg24642439 chr20:33292090 TP53INP2 0.68 6.76 0.38 8.82e-11 Protein C levels; CESC cis rs2066819 1.000 rs80317430 chr12:56727705 G/A cg26734620 chr12:56694298 CS 0.98 5.95 0.34 8.45e-9 Psoriasis vulgaris; CESC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg25809561 chr17:30822961 MYO1D 0.64 9.05 0.49 3.17e-17 Schizophrenia; CESC cis rs2777491 0.957 rs1757454 chr15:41777934 A/G cg18705301 chr15:41695430 NDUFAF1 -0.69 -10.64 -0.55 2.98e-22 Ulcerative colitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04090604 chr21:46222557 UBE2G2 0.42 6.76 0.38 8.99e-11 Gambling; CESC cis rs3749237 0.615 rs11130202 chr3:49566715 C/T cg06212747 chr3:49208901 KLHDC8B 0.47 6.37 0.36 8.2e-10 Resting heart rate; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13453711 chr1:212482804 PPP2R5A -0.46 -6.14 -0.35 2.97e-9 Gut microbiota (bacterial taxa); CESC cis rs12134245 0.755 rs11164928 chr1:92012678 G/A cg25838465 chr1:92012736 NA -0.63 -9.72 -0.51 2.61e-19 Breast cancer; CESC cis rs7267979 0.844 rs6083845 chr20:25388090 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -14.65 -0.67 5.42e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs2425143 1.000 rs10485510 chr20:34445164 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.72 0.33 2.88e-8 Blood protein levels; CESC cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg23583168 chr7:148888333 NA -0.78 -11.33 -0.57 1.54e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs61931739 0.517 rs10772139 chr12:34186178 A/T cg13010199 chr12:38710504 ALG10B 0.48 5.99 0.35 6.66e-9 Morning vs. evening chronotype; CESC cis rs367943 0.698 rs12719164 chr5:112960802 A/C cg12552261 chr5:112820674 MCC 0.45 5.8 0.34 1.88e-8 Type 2 diabetes; CESC cis rs7829975 0.535 rs4841005 chr8:8501230 A/G cg06636001 chr8:8085503 FLJ10661 -0.41 -5.28 -0.31 2.63e-7 Mood instability; CESC trans rs801193 1.000 rs2286684 chr7:66129830 G/T cg26939375 chr7:64535504 NA -0.64 -8.57 -0.47 8.53e-16 Aortic root size; CESC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg08470875 chr2:26401718 FAM59B -0.48 -5.18 -0.3 4.31e-7 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -12.98 -0.62 3.88e-30 Developmental language disorder (linguistic errors); CESC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg09699651 chr6:150184138 LRP11 0.41 5.36 0.31 1.85e-7 Lung cancer; CESC cis rs7914558 0.966 rs1890185 chr10:104748718 A/G cg15744005 chr10:104629667 AS3MT -0.34 -5.45 -0.32 1.18e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9486719 0.843 rs3860231 chr6:97036563 G/A cg06623918 chr6:96969491 KIAA0776 -0.88 -10.52 -0.54 7.14e-22 Migraine;Coronary artery disease; CESC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg26314531 chr2:26401878 FAM59B 0.76 8.45 0.46 1.91e-15 Gut microbiome composition (summer); CESC cis rs6500602 0.964 rs13335685 chr16:4469284 T/C cg08645402 chr16:4508243 NA 0.4 5.99 0.35 6.9e-9 Schizophrenia; CESC cis rs11792861 0.591 rs11791855 chr9:111684139 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.56 8.14 0.45 1.6e-14 Menarche (age at onset); CESC cis rs1595825 0.891 rs73056840 chr2:198783466 C/A cg10820045 chr2:198174542 NA 0.41 5.06 0.3 7.8e-7 Ulcerative colitis; CESC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg19468946 chr17:37922297 IKZF3 0.4 5.13 0.3 5.56e-7 Glomerular filtration rate (creatinine); CESC cis rs1371867 0.875 rs1125706 chr8:101326739 T/A cg11906718 chr8:101322791 RNF19A 0.54 6.89 0.39 4.05e-11 Atrioventricular conduction; CESC cis rs854765 0.654 rs11078400 chr17:17757728 A/G cg16928487 chr17:17741425 SREBF1 0.55 9.61 0.51 6.15e-19 Total body bone mineral density; CESC cis rs35110281 0.774 rs162344 chr21:44954522 G/A cg21573476 chr21:45109991 RRP1B -0.39 -5.42 -0.32 1.37e-7 Mean corpuscular volume; CESC trans rs853679 0.546 rs35353359 chr6:28324378 C/T cg06606381 chr12:133084897 FBRSL1 -1.12 -8.6 -0.47 7.06e-16 Depression; CESC cis rs6088580 0.660 rs6087592 chr20:33114503 A/G cg24642439 chr20:33292090 TP53INP2 0.51 6.63 0.38 1.83e-10 Glomerular filtration rate (creatinine); CESC cis rs9486715 0.809 rs9486467 chr6:96971803 C/T cg06623918 chr6:96969491 KIAA0776 0.96 14.96 0.68 4.24e-37 Headache; CESC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg09323728 chr8:95962352 TP53INP1 -0.41 -8.93 -0.48 7.13e-17 Type 2 diabetes; CESC cis rs36051895 0.664 rs3780372 chr9:5097544 C/T cg02405213 chr9:5042618 JAK2 -0.5 -6.18 -0.35 2.44e-9 Pediatric autoimmune diseases; CESC cis rs9910055 0.502 rs1684662 chr17:42180822 T/A cg19774624 chr17:42201019 HDAC5 0.58 7.92 0.44 6.47e-14 Total body bone mineral density; CESC cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1005277 0.522 rs289645 chr10:37943642 T/C cg25517755 chr10:38738941 LOC399744 -0.4 -5.16 -0.3 4.73e-7 Extrinsic epigenetic age acceleration; CESC cis rs2304069 0.913 rs9324637 chr5:149390947 T/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.92 11.55 0.58 3e-25 HIV-1 control; CESC cis rs748404 0.697 rs530683 chr15:43568999 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -7.82 -0.43 1.29e-13 Lung cancer; CESC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg02569458 chr12:86230093 RASSF9 0.55 7.96 0.44 5.13e-14 Major depressive disorder; CESC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.43 5.79 0.33 2.02e-8 Bipolar disorder; CESC cis rs1451375 0.617 rs12671474 chr7:50591395 C/A cg14593290 chr7:50529359 DDC 0.49 5.9 0.34 1.12e-8 Malaria; CESC cis rs4595586 0.525 rs4441057 chr12:39420620 T/A cg26384229 chr12:38710491 ALG10B 0.59 7.99 0.44 4.11e-14 Morning vs. evening chronotype; CESC cis rs6963495 0.818 rs73190200 chr7:105165856 T/C cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs938554 0.779 rs6449173 chr4:9966105 A/C cg11266682 chr4:10021025 SLC2A9 -0.42 -5.72 -0.33 2.88e-8 Blood metabolite levels; CESC cis rs4919087 1.000 rs11189122 chr10:99072595 G/A cg25902810 chr10:99078978 FRAT1 0.72 10.54 0.54 6.22e-22 Monocyte count; CESC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.42e-7 Lung cancer; CESC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg15147215 chr3:52552868 STAB1 -0.3 -5.18 -0.3 4.5e-7 Electroencephalogram traits; CESC cis rs4547160 0.962 rs12229749 chr12:63503447 C/T cg26727693 chr12:63544175 AVPR1A -0.35 -5.46 -0.32 1.12e-7 Morning vs. evening chronotype; CESC cis rs6964587 1.000 rs7797369 chr7:91570615 C/A cg17063962 chr7:91808500 NA -0.57 -7.62 -0.42 4.53e-13 Breast cancer; CESC cis rs10189230 1.000 rs10189230 chr2:222357961 T/A cg14652038 chr2:222343519 EPHA4 0.35 7.05 0.4 1.59e-11 Urate levels in lean individuals; CESC cis rs7917772 0.502 rs2296584 chr10:104244323 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.65 0.43 3.63e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9457247 0.935 rs2757046 chr6:167374353 C/T cg23791538 chr6:167370224 RNASET2 0.6 8.47 0.46 1.73e-15 Crohn's disease; CESC cis rs11122272 0.705 rs2572260 chr1:231486189 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -6.97 -0.39 2.52e-11 Hemoglobin concentration; CESC cis rs2304069 0.779 rs245050 chr5:149346960 C/G cg12661370 chr5:149340060 SLC26A2 -0.44 -5.13 -0.3 5.53e-7 HIV-1 control; CESC cis rs2066819 1.000 rs79436528 chr12:56686997 C/T cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs10905065 0.866 rs10795547 chr10:5827074 A/G cg11519256 chr10:5708881 ASB13 -0.41 -5.52 -0.32 8.1e-8 Menopause (age at onset); CESC cis rs9303401 0.659 rs17222621 chr17:56695923 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.13 0.63 1.12e-30 Cognitive test performance; CESC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg02564969 chr6:151773285 C6orf211;RMND1 0.62 8.49 0.46 1.47e-15 Menarche (age at onset); CESC cis rs72627123 0.867 rs113257091 chr14:74461121 C/T cg08255017 chr14:74727001 VSX2 0.61 5.06 0.3 7.74e-7 Morning vs. evening chronotype; CESC cis rs9875589 0.628 rs62234602 chr3:14002170 A/G cg19554555 chr3:13937349 NA 0.46 5.42 0.32 1.36e-7 Ovarian reserve; CESC cis rs9811920 0.770 rs4928237 chr3:99731330 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -7.99 -0.44 4.15e-14 Axial length; CESC cis rs796364 0.951 rs2881593 chr2:201000347 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.57 -5.83 -0.34 1.57e-8 Schizophrenia; CESC cis rs1832871 0.711 rs9459904 chr6:158700982 C/T cg07165851 chr6:158734300 TULP4 0.6 6.45 0.37 5.23e-10 Height; CESC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg22105103 chr4:187893119 NA 0.51 7.69 0.43 2.88e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs977987 0.843 rs59155720 chr16:75483806 A/G cg03315344 chr16:75512273 CHST6 0.43 6.18 0.36 2.37e-9 Dupuytren's disease; CESC cis rs861020 1.000 rs861020 chr1:209977111 A/G cg05527609 chr1:210001259 C1orf107 1.05 13.15 0.63 1e-30 Orofacial clefts; CESC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg18230493 chr5:56204884 C5orf35 -0.64 -6.0 -0.35 6.38e-9 Type 2 diabetes; CESC cis rs138857 0.515 rs9616375 chr22:50310600 G/A cg02269571 chr22:50332266 NA -0.7 -6.85 -0.39 5.18e-11 Mean platelet volume; CESC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg10691866 chr7:65817282 TPST1 0.33 5.51 0.32 8.45e-8 Aortic root size; CESC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg21782813 chr7:2030301 MAD1L1 0.44 6.16 0.35 2.7e-9 Bipolar disorder and schizophrenia; CESC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg24642844 chr7:1081250 C7orf50 -0.75 -9.1 -0.49 2.29e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12464559 0.522 rs4414677 chr2:152624932 A/C cg01189475 chr2:152685088 ARL5A -0.65 -6.26 -0.36 1.56e-9 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg25036284 chr2:26402008 FAM59B -0.59 -6.84 -0.39 5.35e-11 Gut microbiome composition (summer); CESC trans rs11098499 0.863 rs1480936 chr4:120462861 C/T cg25214090 chr10:38739885 LOC399744 0.67 9.26 0.49 7.17e-18 Corneal astigmatism; CESC cis rs2204008 0.837 rs12581130 chr12:38319387 A/G cg13010199 chr12:38710504 ALG10B 0.42 5.29 0.31 2.51e-7 Bladder cancer; CESC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 13.27 0.63 3.73e-31 Personality dimensions; CESC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg19774624 chr17:42201019 HDAC5 -0.84 -13.28 -0.63 3.4e-31 Total body bone mineral density; CESC cis rs10751667 0.666 rs10902255 chr11:967268 T/C cg06064525 chr11:970664 AP2A2 -0.48 -9.29 -0.5 5.99e-18 Alzheimer's disease (late onset); CESC cis rs9858542 0.953 rs9878943 chr3:49434654 G/A cg03060546 chr3:49711283 APEH -0.54 -6.16 -0.35 2.67e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6963495 0.745 rs73192150 chr7:105211610 A/C cg19920283 chr7:105172520 RINT1 0.7 6.36 0.36 8.94e-10 Bipolar disorder (body mass index interaction); CESC cis rs6121246 0.511 rs879982 chr20:30398510 A/G cg13852791 chr20:30311386 BCL2L1 0.87 11.25 0.57 2.82e-24 Mean corpuscular hemoglobin; CESC cis rs3820928 0.874 rs6740108 chr2:227889559 G/T cg05526886 chr2:227700861 RHBDD1 0.46 5.95 0.34 8.43e-9 Pulmonary function; CESC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg18876405 chr7:65276391 NA -0.54 -7.7 -0.43 2.66e-13 Aortic root size; CESC cis rs8077889 1.000 rs59044152 chr17:41888747 A/G cg26893861 chr17:41843967 DUSP3 0.82 9.6 0.51 6.18e-19 Triglycerides; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20058270 chr6:43149950 CUL9 -0.51 -6.76 -0.38 8.79e-11 Ulcerative colitis; CESC trans rs7246657 0.943 rs8109632 chr19:37931125 A/T cg24637308 chr11:6592297 DNHD1 0.54 6.34 0.36 1.01e-9 Coronary artery calcification; CESC cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg22590775 chr19:49891494 CCDC155 0.45 5.04 0.3 8.62e-7 Multiple sclerosis; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg23001456 chr17:2615074 KIAA0664 0.58 6.58 0.37 2.5e-10 Psoriatic arthritis; CESC cis rs2280018 0.963 rs4985147 chr16:15168760 T/C cg07549590 chr16:15018862 NA -0.48 -7.78 -0.43 1.6e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7267979 0.966 rs3827014 chr20:25371559 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.23 -0.75 1.11e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs8070128 0.637 rs4925133 chr17:17884801 A/G cg04398451 chr17:18023971 MYO15A -0.6 -8.32 -0.46 4.64e-15 Total body bone mineral density; CESC cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg19539972 chr4:7069911 GRPEL1 0.8 10.59 0.55 4.49e-22 Monocyte percentage of white cells; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg18632527 chr7:6120830 NA -0.46 -6.66 -0.38 1.56e-10 Vertical cup-disc ratio; CESC cis rs2046867 0.818 rs34582798 chr3:72882778 A/C cg25664220 chr3:72788482 NA -0.47 -6.51 -0.37 3.72e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC trans rs681383 1.000 rs57486401 chr18:8331377 T/G cg27042584 chr16:51168485 NA 0.49 5.99 0.35 6.68e-9 Sitting height ratio; CESC cis rs10200159 1.000 rs111707510 chr2:55824236 T/C cg13617705 chr2:55845095 SMEK2 0.68 5.13 0.3 5.67e-7 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25964517 chr4:78034545 NA -0.54 -6.55 -0.37 3.02e-10 Gut microbiome composition (summer); CESC cis rs9346455 1.000 rs9364153 chr6:72012064 G/A cg27238071 chr6:71998145 OGFRL1 0.62 5.52 0.32 8.14e-8 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs28374715 0.662 rs28382348 chr15:41487934 G/C cg18705301 chr15:41695430 NDUFAF1 -0.8 -10.46 -0.54 1.15e-21 Ulcerative colitis; CESC cis rs2439831 1.000 rs2439831 chr15:43784475 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.86 0.52 9.94e-20 Lung cancer in ever smokers; CESC cis rs6502050 0.835 rs35857672 chr17:80078303 G/A cg11859384 chr17:80120422 CCDC57 0.38 5.16 0.3 4.82e-7 Life satisfaction; CESC cis rs72781680 0.664 rs2712076 chr2:23993366 T/C cg08917208 chr2:24149416 ATAD2B 0.6 5.91 0.34 1.04e-8 Lymphocyte counts; CESC cis rs11674184 0.659 rs11679605 chr2:11722468 G/A cg07314298 chr2:11723111 GREB1 -0.62 -9.02 -0.48 3.9e-17 Endometriosis; CESC cis rs9863 0.828 rs4765562 chr12:124472571 T/C cg17562584 chr12:124393655 DNAH10 0.32 5.47 0.32 1.04e-7 White blood cell count; CESC cis rs1580019 0.883 rs6945294 chr7:32472099 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.84 11.42 0.57 8.06e-25 Cognitive ability; CESC cis rs34779708 0.801 rs34592588 chr10:35540134 A/G cg04310649 chr10:35416472 CREM -0.47 -5.38 -0.31 1.67e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs9291683 0.609 rs4622999 chr4:10003395 C/G cg02734326 chr4:10020555 SLC2A9 0.47 6.67 0.38 1.52e-10 Bone mineral density; CESC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg23048001 chr7:2026167 MAD1L1 0.45 5.76 0.33 2.33e-8 Bipolar disorder and schizophrenia; CESC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.86 7.61 0.42 4.8e-13 Depression; CESC cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg17971929 chr21:40555470 PSMG1 1.02 14.69 0.67 3.69e-36 Cognitive function; CESC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg25036284 chr2:26402008 FAM59B -0.57 -6.54 -0.37 3.12e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs7742333 chr6:146159029 A/G cg23711669 chr6:146136114 FBXO30 -0.95 -13.88 -0.65 2.7e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs7267979 1.000 rs6050632 chr20:25432601 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 3e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs12249377 0.519 rs10881838 chr10:92590233 A/G cg14313238 chr10:92632228 RPP30 0.43 5.22 0.31 3.56e-7 White matter microstructure (global fractional anisotropy); CESC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.35 0.31 1.87e-7 Electroencephalogram traits; CESC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.46 -5.28 -0.31 2.65e-7 Breast cancer; CESC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg04369109 chr6:150039330 LATS1 -0.37 -5.05 -0.3 8.32e-7 Lung cancer; CESC cis rs2732480 0.500 rs2450991 chr12:48651621 A/G cg24011408 chr12:48396354 COL2A1 0.44 6.22 0.36 1.95e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7914558 1.000 rs7067970 chr10:104913870 C/T cg04362960 chr10:104952993 NT5C2 0.45 5.89 0.34 1.19e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9479482 1.000 rs5017316 chr6:150333489 A/T cg03788504 chr6:150331562 NA -0.35 -6.91 -0.39 3.55e-11 Alopecia areata; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01166564 chr2:26987492 C2orf18 0.6 6.59 0.38 2.39e-10 Gut microbiome composition (summer); CESC trans rs9300039 0.522 rs75135849 chr11:41964746 T/C cg09735851 chr15:40615289 NA -0.7 -6.05 -0.35 5.04e-9 Type 2 diabetes; CESC cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6547741 1.000 rs6756238 chr2:27841305 G/A cg21248554 chr2:27665150 KRTCAP3 0.25 5.06 0.3 7.8e-7 Oral cavity cancer; CESC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg11890956 chr21:40555474 PSMG1 -0.9 -14.22 -0.66 1.78e-34 Cognitive function; CESC cis rs57506017 0.585 rs3173615 chr7:12269417 C/G cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.58e-7 Neuroticism; CESC cis rs10751667 0.621 rs7396107 chr11:970029 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.47e-7 Alzheimer's disease (late onset); CESC cis rs10851478 0.872 rs12907918 chr15:49816682 G/A cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs7809950 1.000 rs2250414 chr7:107140987 T/G cg23024343 chr7:107201750 COG5 -0.42 -5.91 -0.34 1.05e-8 Coronary artery disease; CESC cis rs2576037 0.583 rs9960463 chr18:44522808 T/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.51 0.32 8.56e-8 Personality dimensions; CESC trans rs10489896 0.541 rs66638830 chr1:234591064 T/G cg23817893 chr11:86085932 CCDC81 -0.45 -6.2 -0.36 2.14e-9 Cognitive test performance; CESC cis rs644799 0.710 rs1852535 chr11:95501241 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.8 11.91 0.59 1.72e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4450798 0.793 rs9882340 chr3:13755427 G/C cg23332027 chr3:13681764 NA 0.42 5.65 0.33 4.2e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7937682 0.889 rs578022 chr11:111490552 G/T cg22437258 chr11:111473054 SIK2 0.72 9.66 0.51 4.24e-19 Primary sclerosing cholangitis; CESC cis rs6570726 0.935 rs432086 chr6:145841593 C/T cg05347473 chr6:146136440 FBXO30 -0.49 -6.65 -0.38 1.68e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6456156 0.526 rs3093025 chr6:167532731 A/G cg07741184 chr6:167504864 NA -0.32 -5.54 -0.32 7.23e-8 Primary biliary cholangitis; CESC trans rs5769765 0.862 rs9616381 chr22:50312382 G/A cg09872104 chr7:134855509 C7orf49 -0.55 -6.27 -0.36 1.47e-9 Schizophrenia; CESC cis rs863345 0.967 rs1418846 chr1:158484285 A/C cg12129480 chr1:158549410 OR10X1 -0.3 -5.87 -0.34 1.28e-8 Pneumococcal bacteremia; CESC cis rs78889164 1.000 rs7255274 chr19:33859589 A/G cg02272751 chr19:33882848 PEPD 0.5 6.8 0.39 6.92e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs2018683 0.899 rs10479816 chr7:28978021 G/A cg19402173 chr7:128379420 CALU -0.54 -7.22 -0.41 5.44e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC trans rs1814175 0.935 rs11040438 chr11:49622521 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -17.77 -0.74 4.61e-47 Height; CESC cis rs2625529 0.590 rs12442886 chr15:72473611 T/C cg16672083 chr15:72433130 SENP8 0.42 6.09 0.35 3.86e-9 Red blood cell count; CESC cis rs73206853 0.764 rs73191817 chr12:110918673 G/A cg12870014 chr12:110450643 ANKRD13A 0.65 5.59 0.32 5.78e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs694739 0.595 rs11542299 chr11:64138805 T/C cg23796481 chr11:64053134 BAD;GPR137 0.59 7.17 0.4 7.64e-12 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg06219351 chr7:158114137 PTPRN2 -0.5 -7.84 -0.43 1.1e-13 Calcium levels; CESC cis rs9902453 0.967 rs56129908 chr17:28421382 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 7.93 0.44 6.25e-14 Coffee consumption (cups per day); CESC cis rs2109514 1.000 rs4727833 chr7:116147908 C/G cg12739419 chr7:116140593 CAV2 -0.36 -6.62 -0.38 2.02e-10 Prevalent atrial fibrillation; CESC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg04511125 chr2:88470314 THNSL2 0.71 6.72 0.38 1.13e-10 Plasma clusterin levels; CESC cis rs7208859 0.623 rs1054397 chr17:29110196 T/C cg19761014 chr17:28927070 LRRC37B2 0.76 6.24 0.36 1.76e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9815354 0.812 rs59873855 chr3:41929538 T/C cg03022575 chr3:42003672 ULK4 0.63 5.98 0.34 7.35e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs4730250 0.654 rs6947857 chr7:106787266 T/G cg02696742 chr7:106810147 HBP1 0.56 5.3 0.31 2.45e-7 Osteoarthritis; CESC cis rs9611565 0.559 rs132771 chr22:42025350 A/G cg06481639 chr22:41940642 POLR3H 0.57 5.97 0.34 7.74e-9 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00872270 chr16:3190814 ZNF213 -0.54 -6.24 -0.36 1.68e-9 Gut microbiome composition (summer); CESC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg05368731 chr17:41323189 NBR1 0.62 8.58 0.47 8.33e-16 Menopause (age at onset); CESC cis rs10781543 0.839 rs4379550 chr9:139376426 C/T cg14169450 chr9:139327907 INPP5E -0.5 -7.71 -0.43 2.59e-13 Monocyte percentage of white cells; CESC cis rs8013055 0.846 rs10139300 chr14:105974501 A/G cg23356831 chr14:105996513 TMEM121 0.37 5.14 0.3 5.23e-7 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CESC cis rs7592578 0.882 rs16832765 chr2:191468762 T/C cg27211696 chr2:191398769 TMEM194B -0.61 -5.32 -0.31 2.25e-7 Diastolic blood pressure; CESC cis rs7264396 0.563 rs2425137 chr20:34345396 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.05 0.4 1.58e-11 Total cholesterol levels; CESC cis rs3820068 0.705 rs16851731 chr1:15860240 A/G cg17385448 chr1:15911702 AGMAT 0.36 5.61 0.33 5.03e-8 Systolic blood pressure; CESC cis rs977987 0.843 rs67409275 chr16:75457212 T/C cg03315344 chr16:75512273 CHST6 0.41 5.98 0.34 7.31e-9 Dupuytren's disease; CESC cis rs7640424 0.649 rs35876429 chr3:107928557 C/T cg09227934 chr3:107805635 CD47 -0.45 -5.82 -0.34 1.66e-8 Body mass index; CESC cis rs4629180 1.000 rs974374 chr2:102105846 C/T cg01388757 chr2:102091195 RFX8 0.44 6.83 0.39 5.91e-11 Chronic rhinosinusitis with nasal polyps; CESC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg04369109 chr6:150039330 LATS1 -0.39 -5.43 -0.32 1.28e-7 Lung cancer; CESC cis rs2439831 0.717 rs10518820 chr15:43888976 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.72 6.32 0.36 1.1e-9 Lung cancer in ever smokers; CESC cis rs2404602 0.716 rs12902174 chr15:76863540 T/C cg22467129 chr15:76604101 ETFA -0.35 -5.24 -0.31 3.24e-7 Blood metabolite levels; CESC cis rs933688 0.502 rs4916858 chr5:90601290 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.44 -5.55 -0.32 6.76e-8 Smoking behavior; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01187952 chr3:63850081 THOC7;ATXN7 0.44 6.29 0.36 1.31e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2243480 1.000 rs4718269 chr7:65200778 C/G cg18252515 chr7:66147081 NA 1.17 11.11 0.56 8.37e-24 Diabetic kidney disease; CESC cis rs3767633 0.764 rs6687226 chr1:161891556 G/T cg09175582 chr1:161736000 ATF6 -0.78 -5.35 -0.31 1.9e-7 IgG glycosylation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21551704 chr5:80550860 RNU5E;RNU5D;CKMT2 0.48 6.68 0.38 1.37e-10 Fibrinogen levels; CESC cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg20503657 chr10:835505 NA 0.77 7.75 0.43 1.93e-13 Eosinophil percentage of granulocytes; CESC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg23754390 chr11:835074 CD151 0.33 5.9 0.34 1.1e-8 Mean platelet volume; CESC cis rs7872515 1.000 rs7872515 chr9:94822540 A/G cg01248375 chr9:94877805 SPTLC1 -0.6 -6.11 -0.35 3.52e-9 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24088639 chr11:34937564 PDHX;APIP 0.57 6.04 0.35 5.18e-9 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.62 0.38 1.95e-10 Bipolar disorder; CESC cis rs7809799 1.000 rs4454228 chr7:98753158 A/G cg05967295 chr7:98741636 SMURF1 -0.72 -5.32 -0.31 2.25e-7 Ulcerative colitis; CESC cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg05347473 chr6:146136440 FBXO30 0.59 7.56 0.42 6.43e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg04944784 chr2:26401820 FAM59B 0.96 10.5 0.54 8.76e-22 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg00166722 chr3:10149974 C3orf24 0.53 6.65 0.38 1.64e-10 Alzheimer's disease; CESC cis rs9443189 0.527 rs775059 chr6:76370130 G/T cg01950844 chr6:76311363 SENP6 0.87 9.27 0.49 6.59e-18 Prostate cancer; CESC cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg25019033 chr10:957182 NA -0.65 -6.53 -0.37 3.28e-10 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20449833 chr2:46770299 RHOQ 0.55 6.11 0.35 3.46e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1153858 1.000 rs1346268 chr15:45673029 T/C cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs748404 0.660 rs2444251 chr15:43788595 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.21 0.45 9.59e-15 Lung cancer; CESC cis rs11190604 1.000 rs4604805 chr10:102261409 C/G cg07080220 chr10:102295463 HIF1AN 0.61 6.25 0.36 1.6e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs72848980 0.512 rs11191749 chr10:105378840 A/G cg00126946 chr10:105363258 SH3PXD2A 0.6 8.52 0.46 1.2e-15 White matter hyperintensity burden; CESC cis rs4409675 0.576 rs1474908 chr1:28213213 C/T cg23691781 chr1:28212827 C1orf38 -0.26 -5.07 -0.3 7.31e-7 Corneal astigmatism; CESC cis rs4555082 0.718 rs2816619 chr14:105732551 G/C cg06808227 chr14:105710500 BRF1 -0.56 -6.2 -0.36 2.18e-9 Mean platelet volume;Platelet distribution width; CESC cis rs2425143 1.000 rs2425143 chr20:34350666 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.72 6.81 0.39 6.58e-11 Blood protein levels; CESC cis rs4423214 1.000 rs12789751 chr11:71164471 G/A cg05163923 chr11:71159392 DHCR7 0.76 10.16 0.53 1.05e-20 Vitamin D levels; CESC cis rs2865126 0.743 rs10502403 chr18:10749140 T/C cg21165219 chr18:10698044 FAM38B -0.51 -5.16 -0.3 4.83e-7 Metabolite levels (5-HIAA/ MHPG Ratio); CESC cis rs611744 0.870 rs613179 chr8:109166006 G/A cg21045802 chr8:109455806 TTC35 0.45 5.49 0.32 9.39e-8 Dupuytren's disease; CESC cis rs2880765 0.743 rs6497194 chr15:86014116 C/T cg10818794 chr15:86012489 AKAP13 -0.34 -5.32 -0.31 2.25e-7 Coronary artery disease; CESC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg04414720 chr1:150670196 GOLPH3L -0.45 -5.7 -0.33 3.23e-8 Urate levels; CESC trans rs11250098 0.574 rs4240672 chr8:10767917 G/A cg15556689 chr8:8085844 FLJ10661 -0.54 -6.67 -0.38 1.5e-10 Morning vs. evening chronotype; CESC cis rs6920965 0.507 rs12203025 chr6:126192034 C/T cg05901451 chr6:126070800 HEY2 -0.41 -5.29 -0.31 2.52e-7 High light scatter reticulocyte count; CESC trans rs208520 0.802 rs1342959 chr6:66883329 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.49 -0.58 4.62e-25 Exhaled nitric oxide output; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg03115081 chr17:74722049 C17orf95;JMJD6 0.44 6.11 0.35 3.49e-9 Weight; CESC cis rs9522267 0.535 rs7323631 chr13:112232269 A/G cg10483660 chr13:112241077 NA -0.33 -5.83 -0.34 1.65e-8 Hepatitis; CESC cis rs3762637 1.000 rs55853677 chr3:122140616 G/A cg24169773 chr3:122142474 KPNA1 -0.52 -6.24 -0.36 1.72e-9 LDL cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21986422 chr20:44519582 CTSA;NEURL2 0.54 6.52 0.37 3.61e-10 Gut microbiome composition (summer); CESC cis rs796364 0.806 rs11674293 chr2:201026743 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.78 -6.71 -0.38 1.2e-10 Schizophrenia; CESC cis rs4727963 0.846 rs11765455 chr7:122736081 C/T cg03640110 chr7:122635026 TAS2R16 -0.36 -5.42 -0.32 1.32e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs4523957 0.583 rs2641437 chr17:2019158 G/A cg16513277 chr17:2031491 SMG6 -0.69 -9.54 -0.51 9.69e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2342371 0.565 rs13084212 chr3:196212211 G/T cg15048948 chr3:196158458 UBXN7 -0.39 -5.5 -0.32 9.12e-8 Fat distribution (HIV); CESC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg06873352 chr17:61820015 STRADA 0.72 12.81 0.62 1.48e-29 Prudent dietary pattern; CESC cis rs56399783 0.901 rs73033408 chr7:2879755 C/T cg19731401 chr7:2775893 GNA12 0.63 5.31 0.31 2.34e-7 Childhood ear infection; CESC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg14338887 chr6:42928500 GNMT 0.35 5.09 0.3 6.83e-7 Alzheimer's disease in APOE e4+ carriers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09975659 chr16:88050166 BANP -0.6 -6.97 -0.39 2.58e-11 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs462853 chr7:65558167 G/C cg13147721 chr7:65941812 NA -0.98 -9.11 -0.49 2.06e-17 Diabetic kidney disease; CESC trans rs8073060 0.544 rs225258 chr17:33956883 C/T cg19694781 chr19:47549865 TMEM160 -0.71 -7.25 -0.41 4.54e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs910316 0.763 rs4556 chr14:75476071 G/C cg08847533 chr14:75593920 NEK9 0.9 15.59 0.69 2.45e-39 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15945262 chr7:1881887 MAD1L1 -0.68 -8.14 -0.45 1.55e-14 Gut microbiome composition (summer); CESC cis rs3892630 0.878 rs66788054 chr19:33190146 G/T cg22980127 chr19:33182716 NUDT19 1.02 11.54 0.58 3.23e-25 Red blood cell traits; CESC cis rs6964587 0.933 rs28671255 chr7:91770705 A/G cg17063962 chr7:91808500 NA 0.56 7.79 0.43 1.53e-13 Breast cancer; CESC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.76 -12.5 -0.61 1.71e-28 Personality dimensions; CESC cis rs911555 0.519 rs8014069 chr14:104004311 A/C cg12935359 chr14:103987150 CKB -0.52 -7.87 -0.44 9.11e-14 Intelligence (multi-trait analysis); CESC cis rs7267979 0.528 rs6076366 chr20:25564626 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.69 -11.03 -0.56 1.57e-23 Liver enzyme levels (alkaline phosphatase); CESC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg06456125 chr7:65229604 NA 0.46 5.97 0.34 7.56e-9 Calcium levels; CESC cis rs34311866 0.808 rs11728344 chr4:963755 T/C cg07828340 chr4:882639 GAK 0.86 6.68 0.38 1.37e-10 Parkinson's disease; CESC cis rs9900062 0.586 rs6504250 chr17:62680553 T/C cg02097616 chr17:62675921 NA 0.42 5.14 0.3 5.46e-7 QT interval; CESC cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg22467129 chr15:76604101 ETFA -0.38 -5.68 -0.33 3.56e-8 Blood metabolite levels; CESC cis rs7255436 0.928 rs7250870 chr19:8453682 C/T cg16745616 chr19:8428856 ANGPTL4 -0.39 -5.86 -0.34 1.36e-8 HDL cholesterol; CESC trans rs2832077 0.527 rs2142375 chr21:30223742 G/A cg14791747 chr16:20752902 THUMPD1 0.53 7.48 0.42 1.12e-12 Cognitive test performance; CESC cis rs6460942 0.544 rs34644264 chr7:12536090 C/A cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs77956314 0.515 rs12299065 chr12:117442304 A/G cg16111737 chr12:117408163 FBXW8 -0.45 -5.46 -0.32 1.08e-7 Subcortical brain region volumes;Hippocampal volume; CESC cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg01475377 chr6:109611718 NA -0.42 -6.43 -0.37 6.01e-10 Reticulocyte fraction of red cells; CESC cis rs4925386 0.840 rs6142738 chr20:60919960 C/T cg22633769 chr20:60982531 CABLES2 -0.51 -5.42 -0.32 1.36e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs7555523 0.778 rs4233408 chr1:165712960 G/A cg24409356 chr1:165738333 TMCO1 0.68 6.27 0.36 1.47e-9 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs3815700 1.000 rs3815700 chr19:33093252 T/C cg24916020 chr19:33096688 ANKRD27 0.6 5.84 0.34 1.56e-8 Eosinophilic esophagitis; CESC cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg24110177 chr3:50126178 RBM5 -0.53 -7.23 -0.41 5.13e-12 Intelligence (multi-trait analysis); CESC trans rs7618501 0.633 rs4688757 chr3:50035323 T/C cg21659725 chr3:3221576 CRBN 0.53 7.41 0.41 1.71e-12 Intelligence (multi-trait analysis); CESC cis rs2014572 1.000 rs3746231 chr19:57760057 G/A cg24459738 chr19:57751996 ZNF805 -0.53 -7.44 -0.42 1.38e-12 Hyperactive-impulsive symptoms; CESC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg15320075 chr8:145703422 NA -0.42 -5.66 -0.33 3.84e-8 Age at first birth; CESC cis rs763121 0.889 rs1043402 chr22:38879688 G/A cg06544989 chr22:39130855 UNC84B 0.45 7.36 0.41 2.34e-12 Menopause (age at onset); CESC cis rs644799 0.544 rs687559 chr11:95598629 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.5 -6.46 -0.37 4.96e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7772486 0.875 rs9322045 chr6:146384950 C/G cg05347473 chr6:146136440 FBXO30 0.49 6.55 0.37 2.97e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs12946454 0.621 rs11651809 chr17:43255681 C/G cg10701640 chr17:43249399 NA 0.45 8.08 0.44 2.31e-14 Systolic blood pressure; CESC cis rs6964587 1.000 rs10274756 chr7:91740796 G/A cg17063962 chr7:91808500 NA 0.56 7.8 0.43 1.38e-13 Breast cancer; CESC cis rs6460942 0.915 rs6460907 chr7:12304449 G/A cg06484146 chr7:12443880 VWDE -0.4 -5.64 -0.33 4.38e-8 Coronary artery disease; CESC cis rs4971059 0.654 rs4971073 chr1:155113104 G/T cg22049894 chr1:155113146 DPM3 0.51 6.55 0.37 2.97e-10 Breast cancer; CESC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg10691866 chr7:65817282 TPST1 -0.3 -5.31 -0.31 2.28e-7 Aortic root size; CESC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg18337363 chr3:52569053 NT5DC2 0.28 5.24 0.31 3.22e-7 Bipolar disorder; CESC cis rs6546550 0.901 rs12613947 chr2:70161342 A/G cg02498382 chr2:70120550 SNRNP27 -0.41 -7.13 -0.4 9.44e-12 Prevalent atrial fibrillation; CESC cis rs634534 0.622 rs1308733 chr11:65720841 T/C cg26695010 chr11:65641043 EFEMP2 0.42 5.32 0.31 2.25e-7 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs6088580 0.634 rs6088508 chr20:33060081 A/G cg24642439 chr20:33292090 TP53INP2 0.52 6.83 0.39 5.96e-11 Glomerular filtration rate (creatinine); CESC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg25072359 chr17:41440525 NA 0.48 6.46 0.37 4.98e-10 Menopause (age at onset); CESC cis rs9814567 0.806 rs13076825 chr3:134317239 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.42 5.52 0.32 8e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg15445000 chr17:37608096 MED1 -0.41 -6.69 -0.38 1.36e-10 Glomerular filtration rate (creatinine); CESC cis rs7197653 0.519 rs55757091 chr16:68323654 G/A cg26727032 chr16:67993705 SLC12A4 -0.6 -6.99 -0.39 2.28e-11 Magnesium levels; CESC cis rs1506636 1.000 rs600774 chr7:123397831 C/T cg03229431 chr7:123269106 ASB15 0.47 6.2 0.36 2.15e-9 Plateletcrit;Platelet count; CESC cis rs2050392 0.789 rs303438 chr10:30733493 C/T cg25182066 chr10:30743637 MAP3K8 0.43 5.82 0.34 1.68e-8 Inflammatory bowel disease; CESC trans rs12480534 0.515 rs62215621 chr20:44761854 C/T cg14765646 chr2:154334450 RPRM -0.72 -6.31 -0.36 1.15e-9 Response to amphetamines; CESC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg14393609 chr7:65229607 NA 0.48 6.5 0.37 4e-10 Aortic root size; CESC cis rs7927592 0.913 rs11228293 chr11:68384646 T/C cg20283391 chr11:68216788 NA -0.61 -7.3 -0.41 3.45e-12 Total body bone mineral density; CESC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9399401 0.633 rs262118 chr6:142843054 C/A cg04461802 chr6:142623433 GPR126 0.4 5.53 0.32 7.53e-8 Chronic obstructive pulmonary disease; CESC cis rs6967414 0.786 rs3757482 chr7:6748927 A/G cg09896999 chr7:6746977 ZNF12 -0.58 -7.08 -0.4 1.32e-11 Hematocrit;Hemoglobin concentration; CESC cis rs7851660 0.967 rs4743135 chr9:100599493 C/T cg13688889 chr9:100608707 NA -0.68 -10.61 -0.55 3.8e-22 Strep throat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21080633 chr12:132263633 SFRS8 -0.66 -7.19 -0.4 6.55e-12 Gut microbiome composition (summer); CESC cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg24130564 chr14:104152367 KLC1 -0.48 -6.32 -0.36 1.07e-9 Reticulocyte count; CESC cis rs734999 0.545 rs4074789 chr1:2537464 A/G cg20673091 chr1:2541236 MMEL1 0.45 7.86 0.43 9.78e-14 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27622633 chr4:120133607 USP53 0.59 6.68 0.38 1.42e-10 Gut microbiome composition (summer); CESC cis rs9640161 0.830 rs17173681 chr7:150059414 A/G cg17279839 chr7:150038598 RARRES2 -0.42 -5.39 -0.31 1.55e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs748404 0.560 rs572837 chr15:43823813 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.49 7.47 0.42 1.15e-12 Lung cancer; CESC cis rs6088580 0.634 rs6120642 chr20:33012531 A/G cg06115741 chr20:33292138 TP53INP2 0.48 6.13 0.35 3.18e-9 Glomerular filtration rate (creatinine); CESC cis rs6120849 0.754 rs3746435 chr20:33587198 G/C cg24642439 chr20:33292090 TP53INP2 0.66 6.52 0.37 3.59e-10 Protein C levels; CESC trans rs7980799 0.716 rs1351683 chr12:33598563 G/A cg26384229 chr12:38710491 ALG10B -0.57 -8.23 -0.45 8.3e-15 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg11644478 chr21:40555479 PSMG1 -0.78 -11.6 -0.58 1.92e-25 Cognitive function; CESC trans rs7246760 1.000 rs7246772 chr19:9886283 C/T cg02900749 chr2:68251473 NA -0.82 -7.08 -0.4 1.33e-11 Pursuit maintenance gain; CESC cis rs116095464 0.867 rs10061296 chr5:312253 G/A cg10591111 chr5:226296 SDHA -0.61 -5.71 -0.33 3.05e-8 Breast cancer; CESC cis rs12618769 0.597 rs7593615 chr2:99030598 C/A cg10123293 chr2:99228465 UNC50 0.4 5.32 0.31 2.21e-7 Bipolar disorder; CESC cis rs9400271 0.632 rs9384705 chr6:109588244 T/C cg01475377 chr6:109611718 NA -0.46 -7.13 -0.4 9.29e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs7395581 0.959 rs2013867 chr11:47260272 A/G cg25783544 chr11:47291846 MADD 0.58 7.45 0.42 1.29e-12 HDL cholesterol; CESC cis rs9486715 0.659 rs9399930 chr6:96854444 G/T cg06623918 chr6:96969491 KIAA0776 0.87 12.52 0.61 1.42e-28 Headache; CESC trans rs6948772 0.923 rs6948795 chr7:155400949 T/C cg19946641 chr12:130909093 RIMBP2 -0.32 -5.99 -0.35 6.68e-9 Colorectal cancer; CESC cis rs17818399 0.612 rs4952834 chr2:46777462 C/G cg06386533 chr2:46925753 SOCS5 0.5 6.13 0.35 3.13e-9 Height; CESC cis rs8028182 0.636 rs11637068 chr15:75743002 G/A cg20655648 chr15:75932815 IMP3 0.48 6.11 0.35 3.62e-9 Sudden cardiac arrest; CESC cis rs826838 1.000 rs7975243 chr12:38849220 C/T cg26384229 chr12:38710491 ALG10B 0.83 14.57 0.67 1.05e-35 Heart rate; CESC cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg17366294 chr4:99064904 C4orf37 0.62 8.8 0.48 1.82e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6752107 0.503 rs2304776 chr2:234227693 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.39 5.06 0.3 7.94e-7 Crohn's disease;Inflammatory bowel disease; CESC trans rs6560039 1 rs6560039 chr9:90474946 C/T cg24436365 chr6:63940138 NA 0.56 10.72 0.55 1.68e-22 Gait variability; CESC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg02569458 chr12:86230093 RASSF9 0.49 7.68 0.43 3.04e-13 Major depressive disorder; CESC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg11663144 chr21:46675770 NA -0.56 -8.41 -0.46 2.52e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6495122 0.699 rs1378940 chr15:75083494 C/A cg09165964 chr15:75287851 SCAMP5 0.4 5.21 0.31 3.72e-7 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs1568889 0.887 rs2062269 chr11:28116537 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.53 0.64 4.71e-32 Bipolar disorder; CESC cis rs12142240 0.731 rs6681857 chr1:46850124 T/C cg00530320 chr1:46809349 NSUN4 0.6 8.05 0.44 2.83e-14 Menopause (age at onset); CESC cis rs761746 0.960 rs9621279 chr22:31949800 T/A cg25791279 chr22:32026902 PISD 0.49 5.61 0.33 5.09e-8 Intelligence; CESC cis rs7089973 0.604 rs11196937 chr10:116589500 G/C cg25233709 chr10:116636983 FAM160B1 0.38 5.9 0.34 1.12e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9322193 0.607 rs10457852 chr6:150201720 C/T cg01145232 chr6:150245071 RAET1G 0.49 5.95 0.34 8.24e-9 Lung cancer; CESC cis rs751728 1.000 rs6920075 chr6:33731797 C/T cg15252951 chr6:33757062 LEMD2 0.45 5.84 0.34 1.53e-8 Crohn's disease; CESC cis rs2455799 0.613 rs1345157 chr3:15895581 C/G cg16303742 chr3:15540471 COLQ -0.37 -5.51 -0.32 8.42e-8 Mean platelet volume; CESC cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg15605315 chr1:45957053 TESK2 0.42 5.3 0.31 2.42e-7 High light scatter reticulocyte count; CESC cis rs6570726 0.935 rs367612 chr6:145828987 A/G cg05347473 chr6:146136440 FBXO30 0.42 5.7 0.33 3.11e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg21770322 chr7:97807741 LMTK2 0.54 8.15 0.45 1.45e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg07507251 chr3:52567010 NT5DC2 0.4 6.96 0.39 2.7e-11 Bipolar disorder; CESC cis rs9512730 0.553 rs9512702 chr13:28033485 A/G cg04070771 chr13:27998621 GTF3A 0.48 5.44 0.32 1.23e-7 Schizophrenia; CESC cis rs3892630 0.824 rs35654350 chr19:33223766 T/C cg22980127 chr19:33182716 NUDT19 1.03 11.32 0.57 1.67e-24 Red blood cell traits; CESC cis rs34779708 0.931 rs4934731 chr10:35431636 T/C cg03585969 chr10:35415529 CREM 0.75 9.84 0.52 1.11e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg09877947 chr5:131593287 PDLIM4 0.46 6.0 0.35 6.47e-9 Breast cancer; CESC trans rs2853203 0.610 rs2595585 chr20:3602060 A/G cg08803490 chr12:80288661 PPP1R12A -0.57 -6.03 -0.35 5.63e-9 High light scatter reticulocyte count;Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs4654899 0.865 rs6693020 chr1:21378057 A/G cg05370193 chr1:21551575 ECE1 0.42 6.16 0.35 2.75e-9 Superior frontal gyrus grey matter volume; CESC cis rs12618769 0.543 rs58778964 chr2:99110599 G/C cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17446970 chr1:167683495 NA -0.49 -6.0 -0.35 6.51e-9 Ulcerative colitis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06397424 chr16:15737279 NDE1;KIAA0430 0.46 6.38 0.36 7.89e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7697216 0.604 rs1319629 chr4:175821735 C/T cg14561282 chr4:175839468 ADAM29 -0.48 -5.56 -0.32 6.75e-8 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26297968 chr2:211035960 C2orf67 -0.49 -7.24 -0.41 4.83e-12 Gut microbiota (bacterial taxa); CESC cis rs708547 0.914 rs2412760 chr4:57735192 A/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.62 -6.73 -0.38 1.06e-10 Response to bleomycin (chromatid breaks); CESC cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.34 0.46 4.2e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9583531 0.629 rs7991766 chr13:111380684 A/G cg24331049 chr13:111365604 ING1 0.69 9.86 0.52 9.59e-20 Coronary artery disease; CESC cis rs977987 0.778 rs4243112 chr16:75321031 T/C cg03315344 chr16:75512273 CHST6 0.38 5.43 0.32 1.3e-7 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16376438 chr16:69458483 CYB5B -0.54 -6.19 -0.36 2.23e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14418275 chr11:66243281 PELI3 0.52 7.02 0.4 1.89e-11 Fibrinogen levels; CESC cis rs6032067 0.852 rs17424613 chr20:43806441 C/T cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.5e-8 Blood protein levels; CESC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg26732615 chr19:19648335 CILP2;YJEFN3 -0.43 -5.43 -0.32 1.24e-7 Tonsillectomy; CESC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg12379764 chr21:47803548 PCNT 0.47 6.04 0.35 5.07e-9 Testicular germ cell tumor; CESC cis rs5769765 0.778 rs8137331 chr22:50313358 G/C cg26441486 chr22:50317300 CRELD2 0.42 5.61 0.33 5.04e-8 Schizophrenia; CESC cis rs7772486 0.806 rs2247317 chr6:146217570 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.45 0.37 5.3e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs933688 0.941 rs6452954 chr5:90735692 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.9 11.83 0.59 3.41e-26 Smoking behavior; CESC cis rs2735413 0.918 rs1922612 chr16:78052983 G/C cg04733911 chr16:78082701 NA -0.41 -6.26 -0.36 1.54e-9 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg18099408 chr3:52552593 STAB1 -0.3 -5.05 -0.3 8.07e-7 Bipolar disorder; CESC trans rs2018683 0.677 rs12531456 chr7:28970611 A/C cg19402173 chr7:128379420 CALU -0.53 -7.04 -0.4 1.61e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs35306767 0.953 rs1106064 chr10:957211 G/A cg20503657 chr10:835505 NA 0.74 8.11 0.45 1.89e-14 Eosinophil percentage of granulocytes; CESC cis rs1983891 1.000 rs4714483 chr6:41528214 G/A cg20194872 chr6:41519635 FOXP4 0.56 8.09 0.45 2.16e-14 Prostate cancer; CESC cis rs72781680 0.611 rs72783605 chr2:24287864 A/G cg08917208 chr2:24149416 ATAD2B 0.54 5.2 0.3 4e-7 Lymphocyte counts; CESC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg11905131 chr22:24372483 LOC391322 0.65 7.63 0.42 4.17e-13 Urinary 1,3-butadiene metabolite levels in smokers; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02025656 chr7:668612 PRKAR1B 0.44 6.13 0.35 3.1e-9 Fibrinogen levels; CESC cis rs9614461 0.702 rs3788648 chr22:45727180 G/A cg01808030 chr22:45809952 RIBC2;SMC1B 0.71 7.4 0.41 1.81e-12 Tonsillectomy; CESC cis rs9650657 0.645 rs11774552 chr8:10515679 C/T cg27411982 chr8:10470053 RP1L1 -0.4 -5.21 -0.3 3.74e-7 Neuroticism; CESC cis rs7809950 1.000 rs12667527 chr7:107086969 T/C cg23024343 chr7:107201750 COG5 -0.42 -6.0 -0.35 6.39e-9 Coronary artery disease; CESC cis rs7605827 0.930 rs2111454 chr2:15522331 G/A cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs911555 0.755 rs12435516 chr14:103954404 T/C cg24130564 chr14:104152367 KLC1 0.48 6.21 0.36 2.09e-9 Intelligence (multi-trait analysis); CESC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg21784768 chr11:537496 LRRC56 -0.53 -5.08 -0.3 7.16e-7 Body mass index; CESC cis rs13191362 1.000 rs13206253 chr6:163166902 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.68 7.18 0.4 7.2e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.37 0.36 8.21e-10 Bipolar disorder; CESC cis rs116095464 0.614 rs4371799 chr5:268192 C/A cg10591111 chr5:226296 SDHA -0.51 -6.25 -0.36 1.67e-9 Breast cancer; CESC cis rs4654899 1.000 rs10916938 chr1:21446883 A/G cg05370193 chr1:21551575 ECE1 0.38 5.65 0.33 4.17e-8 Superior frontal gyrus grey matter volume; CESC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs225245 0.817 rs225269 chr17:33967931 G/T cg05299278 chr17:33885742 SLFN14 0.38 5.52 0.32 8.1e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs3857536 0.719 rs9363555 chr6:66930332 T/C cg07460842 chr6:66804631 NA -0.41 -5.19 -0.3 4.18e-7 Blood trace element (Cu levels); CESC cis rs11958404 0.860 rs72818111 chr5:157438361 A/G cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg00149659 chr3:10157352 C3orf10 0.7 8.26 0.45 6.82e-15 Alzheimer's disease; CESC cis rs3105593 0.965 rs11070801 chr15:50943685 A/T cg08437265 chr15:50716283 USP8 0.42 5.45 0.32 1.14e-7 QT interval; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg23008136 chr2:55743936 NA 0.42 6.41 0.37 6.67e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9584850 0.834 rs4294654 chr13:99119607 G/A cg20750642 chr13:99100586 FARP1 -0.39 -5.9 -0.34 1.12e-8 Neuroticism; CESC cis rs9486715 0.830 rs2255552 chr6:96999643 A/G cg18709589 chr6:96969512 KIAA0776 -0.45 -6.37 -0.36 8.1e-10 Headache; CESC cis rs9457247 0.588 rs35171809 chr6:167432766 A/G cg23791538 chr6:167370224 RNASET2 -0.54 -7.3 -0.41 3.28e-12 Crohn's disease; CESC cis rs12971120 0.947 rs7241558 chr18:72169267 A/T cg26446133 chr18:72167187 CNDP2 -0.74 -11.03 -0.56 1.57e-23 Refractive error; CESC cis rs9309473 0.607 rs2421489 chr2:73593448 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -5.93 -0.34 9.21e-9 Metabolite levels; CESC cis rs2404602 0.735 rs11632222 chr15:76712927 C/G cg00316803 chr15:76480434 C15orf27 0.37 5.07 0.3 7.52e-7 Blood metabolite levels; CESC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.2e-17 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05382772 chr11:65686513 DRAP1;C11orf68 -0.59 -6.82 -0.39 6.32e-11 Gut microbiome composition (summer); CESC cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 6.25 0.36 1.61e-9 Eosinophil percentage of white cells; CESC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.35 0.8 1.61e-59 Prudent dietary pattern; CESC cis rs6499255 0.951 rs75815213 chr16:69702854 C/T cg15192750 chr16:69999425 NA 0.47 5.4 0.31 1.5e-7 IgE levels; CESC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg18404041 chr3:52824283 ITIH1 -0.36 -6.05 -0.35 4.82e-9 Bipolar disorder; CESC cis rs11785400 0.762 rs1137522 chr8:143739020 A/C cg10596483 chr8:143751796 JRK 0.42 5.31 0.31 2.32e-7 Schizophrenia; CESC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg18876405 chr7:65276391 NA 0.53 7.28 0.41 3.9e-12 Aortic root size; CESC cis rs72945132 0.882 rs67093918 chr11:70198999 C/A cg00319359 chr11:70116639 PPFIA1 0.73 6.96 0.39 2.63e-11 Coronary artery disease; CESC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg13012494 chr21:47604986 C21orf56 0.49 6.54 0.37 3.17e-10 Testicular germ cell tumor; CESC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.43 -5.43 -0.32 1.24e-7 Tonsillectomy; CESC cis rs76878669 0.561 rs55998145 chr11:66152586 A/G cg18002602 chr11:66138449 SLC29A2 0.42 6.99 0.39 2.22e-11 Educational attainment (years of education); CESC cis rs7927592 0.673 rs2510392 chr11:68394457 C/G cg01657329 chr11:68192670 LRP5 -0.46 -5.83 -0.34 1.6e-8 Total body bone mineral density; CESC cis rs8180040 1.000 rs295461 chr3:47368010 T/C cg27129171 chr3:47204927 SETD2 0.66 10.0 0.52 3.6e-20 Colorectal cancer; CESC trans rs11098499 0.821 rs28665282 chr4:120384186 C/T cg25214090 chr10:38739885 LOC399744 0.69 9.79 0.52 1.58e-19 Corneal astigmatism; CESC cis rs782590 0.934 rs17369191 chr2:55757885 T/C cg18811423 chr2:55921094 PNPT1 0.81 12.92 0.62 6.08e-30 Metabolic syndrome; CESC cis rs644799 1.000 rs680134 chr11:95559517 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.92 14.08 0.65 5.5e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs6751744 0.855 rs35019796 chr2:160367155 A/G cg08183425 chr2:86037857 NA 0.35 6.04 0.35 5.22e-9 Dysphagia; CESC cis rs4481887 0.927 rs4376768 chr1:248476088 A/G cg00666640 chr1:248458726 OR2T12 -0.35 -5.91 -0.34 1.02e-8 Common traits (Other); CESC cis rs57786342 0.624 rs4899262 chr14:69283545 G/A cg03189333 chr14:69283534 NA -0.44 -5.03 -0.3 8.88e-7 Macrophage inflammatory protein 1a levels; CESC trans rs11989744 1.000 rs17089546 chr8:23571807 G/A cg03492747 chr16:86543808 FOXF1 0.68 7.75 0.43 1.92e-13 Waist-hip ratio; CESC cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg25019033 chr10:957182 NA -0.58 -6.13 -0.35 3.11e-9 Eosinophil percentage of granulocytes; CESC cis rs10851478 0.872 rs17479589 chr15:49753532 T/C cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.16 0.3 4.79e-7 Oral cavity cancer; CESC cis rs2228479 1.000 rs11642267 chr16:89957635 T/C cg06558623 chr16:89946397 TCF25 1.17 9.37 0.5 3.29e-18 Skin colour saturation; CESC cis rs1801251 1.000 rs67013068 chr2:233608253 G/C cg08000102 chr2:233561755 GIGYF2 0.64 9.09 0.49 2.37e-17 Coronary artery disease; CESC cis rs1707322 1.000 rs10890355 chr1:46317348 G/A cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11864453 0.826 rs9941087 chr16:72118324 G/A cg01557791 chr16:72042693 DHODH -0.56 -7.33 -0.41 2.78e-12 Fibrinogen levels; CESC trans rs61931739 0.500 rs10844864 chr12:34532468 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 8.03e-13 Morning vs. evening chronotype; CESC trans rs11098499 0.754 rs2036856 chr4:120249288 G/A cg25214090 chr10:38739885 LOC399744 0.62 8.64 0.47 5.24e-16 Corneal astigmatism; CESC cis rs9916302 0.904 rs9898170 chr17:37510092 T/C cg00129232 chr17:37814104 STARD3 0.52 6.49 0.37 4.13e-10 Glomerular filtration rate (creatinine); CESC cis rs9815354 0.767 rs12185934 chr3:41836558 A/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg17372223 chr3:52568218 NT5DC2 0.4 5.7 0.33 3.14e-8 Bipolar disorder; CESC cis rs7851660 0.933 rs1867277 chr9:100615914 A/G cg13688889 chr9:100608707 NA -0.69 -10.57 -0.54 4.92e-22 Strep throat; CESC cis rs10256972 0.527 rs28671326 chr7:1174973 G/A cg15112475 chr7:1198522 ZFAND2A -0.38 -6.01 -0.35 5.98e-9 Longevity;Endometriosis; CESC cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg19046167 chr17:80928561 B3GNTL1 -0.39 -5.08 -0.3 7.23e-7 Breast cancer; CESC cis rs80130819 0.748 rs2732477 chr12:48700282 C/T cg05342945 chr12:48394962 COL2A1 0.52 5.72 0.33 2.95e-8 Prostate cancer; CESC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg26314531 chr2:26401878 FAM59B -0.83 -9.19 -0.49 1.22e-17 Gut microbiome composition (summer); CESC cis rs11645898 0.683 rs72787038 chr16:72066102 A/C cg14768367 chr16:72042858 DHODH -0.65 -5.55 -0.32 6.86e-8 Blood protein levels; CESC cis rs2797160 0.935 rs6940748 chr6:125994080 C/T cg05901451 chr6:126070800 HEY2 -0.45 -6.5 -0.37 3.89e-10 Endometrial cancer; CESC cis rs17376456 0.597 rs11135401 chr5:93365716 G/A cg25358565 chr5:93447407 FAM172A -0.47 -5.53 -0.32 7.81e-8 Diabetic retinopathy; CESC cis rs7084402 0.967 rs1649080 chr10:60293294 C/T cg07615347 chr10:60278583 BICC1 0.58 9.43 0.5 2.24e-18 Refractive error; CESC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg11764359 chr7:65958608 NA -0.81 -9.98 -0.52 4.19e-20 Aortic root size; CESC cis rs9815354 0.812 rs17215883 chr3:41841873 C/T cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.2e-11 Tonsillectomy; CESC cis rs1465370 0.720 rs7811463 chr7:130017488 G/A cg04743876 chr7:130013617 NA 0.31 5.87 0.34 1.27e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs453301 0.606 rs6981060 chr8:8908235 C/A cg15556689 chr8:8085844 FLJ10661 -0.5 -5.96 -0.34 7.83e-9 Joint mobility (Beighton score); CESC cis rs477692 0.655 rs7906680 chr10:131442671 C/G cg24747557 chr10:131355152 MGMT 0.39 5.5 0.32 9.15e-8 Response to temozolomide; CESC cis rs9399401 0.845 rs263178 chr6:142865106 C/T cg03128060 chr6:142623767 GPR126 0.26 5.05 0.3 8.17e-7 Chronic obstructive pulmonary disease; CESC cis rs7662987 0.517 rs2602878 chr4:100039953 T/G cg12011299 chr4:100065546 ADH4 0.6 6.48 0.37 4.4e-10 Smoking initiation; CESC cis rs8002861 0.905 rs12874535 chr13:44433565 A/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.41 -5.16 -0.3 4.82e-7 Leprosy; CESC cis rs2301436 0.512 rs6925969 chr6:167501738 C/A cg07741184 chr6:167504864 NA 0.39 6.49 0.37 4.23e-10 Crohn's disease; CESC cis rs5498 0.869 rs2569702 chr19:10403947 A/G cg10604476 chr19:10403908 ICAM5 0.45 6.37 0.36 8.14e-10 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs208520 0.754 rs851592 chr6:66875175 G/T cg07460842 chr6:66804631 NA -0.99 -13.04 -0.63 2.24e-30 Exhaled nitric oxide output; CESC cis rs73206853 0.925 rs12318836 chr12:110642190 A/C cg12870014 chr12:110450643 ANKRD13A 0.65 6.23 0.36 1.81e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1843834 0.929 rs4674934 chr2:225516468 A/T cg22455342 chr2:225449267 CUL3 -0.51 -6.63 -0.38 1.9e-10 IgE levels in asthmatics (D.p. specific); CESC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg24829409 chr8:58192753 C8orf71 -0.67 -8.05 -0.44 2.82e-14 Developmental language disorder (linguistic errors); CESC cis rs7089973 0.604 rs11196947 chr10:116601372 G/A cg25233709 chr10:116636983 FAM160B1 0.38 6.08 0.35 4.13e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1023500 0.573 rs133378 chr22:42467695 G/C cg15557168 chr22:42548783 NA -0.45 -6.51 -0.37 3.78e-10 Schizophrenia; CESC cis rs9393777 0.545 rs56303243 chr6:26485727 G/A cg12826209 chr6:26865740 GUSBL1 0.67 7.01 0.4 2.02e-11 Intelligence (multi-trait analysis); CESC cis rs3762637 0.943 rs72960447 chr3:122235105 G/A cg24169773 chr3:122142474 KPNA1 -0.59 -6.97 -0.39 2.48e-11 LDL cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25481680 chr10:105110878 PCGF6 0.57 6.35 0.36 9.47e-10 Gut microbiome composition (summer); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00419759 chr1:114301964 PHTF1 -0.48 -6.3 -0.36 1.2e-9 Height; CESC cis rs9796 0.689 rs576336 chr15:41452771 C/T cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.61 -0.38 2.16e-10 Menopause (age at onset); CESC cis rs4689388 0.890 rs4342257 chr4:6290037 G/C cg25554036 chr4:6271136 WFS1 0.53 8.69 0.47 3.77e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02930876 chr14:24584326 DCAF11 -0.6 -6.35 -0.36 9.45e-10 Gut microbiome composition (summer); CESC cis rs637571 0.522 rs649000 chr11:65742933 T/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 5.9 0.34 1.08e-8 Eosinophil percentage of white cells; CESC cis rs11997175 0.624 rs67643247 chr8:33700790 G/A ch.8.33884649F chr8:33765107 NA 0.54 6.87 0.39 4.59e-11 Body mass index; CESC cis rs12458462 0.892 rs12456692 chr18:77482189 C/T cg23301140 chr18:77439876 CTDP1 0.56 7.34 0.41 2.68e-12 Monocyte count; CESC trans rs17556665 0.808 rs2031014 chr11:14051977 C/T cg13843613 chr1:177140126 FAM5B 0.5 6.17 0.35 2.61e-9 Inflammatory biomarkers; CESC cis rs2273669 0.667 rs7761290 chr6:109326621 T/G cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg05332525 chr7:65337924 VKORC1L1 -0.49 -6.13 -0.35 3.24e-9 Aortic root size; CESC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg22903657 chr4:1355424 KIAA1530 -0.38 -5.26 -0.31 3.03e-7 Obesity-related traits; CESC cis rs12479064 0.724 rs62153852 chr2:99934713 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.59 -7.1 -0.4 1.13e-11 Chronic sinus infection; CESC cis rs910316 0.737 rs398896 chr14:75482827 C/A cg08847533 chr14:75593920 NEK9 -0.9 -15.44 -0.69 8.26e-39 Height; CESC cis rs1018836 0.828 rs1858673 chr8:91551526 C/A cg16814680 chr8:91681699 NA -0.64 -9.21 -0.49 1.05e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21754773 chr3:58477622 KCTD6 0.51 6.47 0.37 4.59e-10 Gut microbiota (bacterial taxa); CESC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg01416388 chr22:39784598 NA -0.55 -6.65 -0.38 1.68e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19825186 chr1:207495562 CD55 0.6 6.6 0.38 2.28e-10 Gut microbiome composition (summer); CESC cis rs2953174 0.786 rs2975749 chr2:241519093 A/G cg07929629 chr2:241523174 NA 0.62 5.63 0.33 4.52e-8 Bipolar disorder; CESC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.86 8.86 0.48 1.18e-16 Platelet count; CESC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg15052019 chr19:19431593 KIAA0892;SF4 -0.43 -5.49 -0.32 9.31e-8 Tonsillectomy; CESC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.7 -8.01 -0.44 3.69e-14 Gut microbiome composition (summer); CESC cis rs870825 0.616 rs4444872 chr4:185628405 A/G cg04058563 chr4:185651563 MLF1IP 0.65 7.07 0.4 1.36e-11 Blood protein levels; CESC cis rs2742234 0.541 rs11238483 chr10:43728780 A/G cg07801480 chr10:43725741 RASGEF1A -0.42 -5.32 -0.31 2.19e-7 Hirschsprung disease; CESC cis rs1707322 0.963 rs10890373 chr1:46393755 A/C cg03146154 chr1:46216737 IPP 0.78 10.78 0.55 1.06e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.62 5.76 0.33 2.34e-8 LDL cholesterol;Cholesterol, total; CESC cis rs12824058 0.831 rs11060825 chr12:130807905 A/G cg23887609 chr12:130822674 PIWIL1 0.45 5.87 0.34 1.28e-8 Menopause (age at onset); CESC cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.29 0.45 5.87e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13859212 chr4:99580143 TSPAN5 0.54 6.71 0.38 1.18e-10 Gut microbiome composition (summer); CESC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg09658497 chr7:2847517 GNA12 0.41 5.99 0.35 6.82e-9 Height; CESC cis rs11650494 0.710 rs2165701 chr17:47475822 A/G cg08112188 chr17:47440006 ZNF652 1.18 7.8 0.43 1.43e-13 Prostate cancer; CESC cis rs10911363 0.592 rs2761581 chr1:183474850 G/C cg09173681 chr1:183549694 NCF2 0.51 7.36 0.41 2.28e-12 Systemic lupus erythematosus; CESC cis rs131777 0.547 rs131753 chr22:51022862 A/G cg25309564 chr22:51001381 C22orf41 0.62 7.99 0.44 4.25e-14 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Parkinson's disease; CESC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.51 -0.32 8.59e-8 Huntington's disease progression; CESC cis rs8053891 0.906 rs28714527 chr16:71997862 C/G cg04254540 chr16:71951199 KIAA0174 -0.44 -5.46 -0.32 1.07e-7 Coronary artery disease; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg25062197 chr8:90894030 NA 0.37 5.99 0.35 6.69e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9467711 0.606 rs72836482 chr6:26359241 A/T cg14345882 chr6:26364793 BTN3A2 0.59 6.06 0.35 4.66e-9 Autism spectrum disorder or schizophrenia; CESC trans rs208520 0.754 rs12204635 chr6:66740779 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 12.2 0.6 1.84e-27 Exhaled nitric oxide output; CESC trans rs62103177 0.564 rs1864529 chr18:77748975 G/A cg05926928 chr17:57297772 GDPD1 -0.7 -7.61 -0.42 4.81e-13 Opioid sensitivity; CESC cis rs17376456 0.825 rs10058331 chr5:93279115 T/G cg25358565 chr5:93447407 FAM172A 1.15 9.92 0.52 6.06e-20 Diabetic retinopathy; CESC cis rs3924048 0.559 rs4075304 chr1:12626803 C/T cg00291366 chr1:12616550 NA 0.35 6.13 0.35 3.24e-9 Optic cup area; CESC trans rs1814175 0.684 rs1827015 chr11:49585241 A/G cg03929089 chr4:120376271 NA -0.82 -11.46 -0.58 5.79e-25 Height; CESC cis rs3026101 0.671 rs14231 chr17:5294976 T/A cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg12826209 chr6:26865740 GUSBL1 0.75 8.82 0.48 1.62e-16 Intelligence (multi-trait analysis); CESC cis rs929354 0.739 rs1182439 chr7:157027367 G/A cg05182265 chr7:156933206 UBE3C 0.48 7.11 0.4 1.05e-11 Body mass index; CESC cis rs9291683 0.632 rs13101785 chr4:10042915 T/A cg00071950 chr4:10020882 SLC2A9 0.83 14.41 0.66 3.63e-35 Bone mineral density; CESC cis rs75804782 0.521 rs56227677 chr2:239449867 C/T cg18131467 chr2:239335373 ASB1 -0.68 -5.47 -0.32 1.04e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg26408565 chr15:76604113 ETFA -0.4 -5.91 -0.34 1.03e-8 Blood metabolite levels; CESC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg09359103 chr1:154839909 KCNN3 -0.66 -12.34 -0.6 5.94e-28 Prostate cancer; CESC cis rs6582630 0.537 rs7299661 chr12:38527713 C/T cg13010199 chr12:38710504 ALG10B 0.42 5.53 0.32 7.64e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs329122 0.528 rs329121 chr5:133863352 G/C cg26284174 chr5:133860141 NA 0.49 5.74 0.33 2.63e-8 Body mass index;Type 2 diabetes; CESC cis rs11711311 1.000 rs11719303 chr3:113494524 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.71 9.99 0.52 3.72e-20 IgG glycosylation; CESC cis rs344364 0.511 rs1742462 chr16:1946062 A/C cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12390003 chr1:160068671 IGSF8 -0.51 -6.2 -0.36 2.2e-9 Ulcerative colitis; CESC cis rs1728785 1.000 rs698712 chr16:68561879 G/A cg02972257 chr16:68554789 NA -0.55 -6.45 -0.37 5.28e-10 Ulcerative colitis; CESC cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.73 8.85 0.48 1.24e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs8060686 0.623 rs2301814 chr16:68105171 C/G cg26727032 chr16:67993705 SLC12A4 -0.57 -7.63 -0.42 4.3e-13 HDL cholesterol;Metabolic syndrome; CESC cis rs17384381 1.000 rs12133722 chr1:85873237 C/T cg16011679 chr1:85725395 C1orf52 0.79 8.03 0.44 3.2e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg11764359 chr7:65958608 NA -0.79 -11.67 -0.58 1.16e-25 Aortic root size; CESC cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg23649088 chr2:200775458 C2orf69 0.73 9.23 0.49 9.22e-18 Osteoporosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01143145 chr6:33547969 BAK1 0.47 6.01 0.35 6.27e-9 Gut microbiota (bacterial taxa); CESC cis rs4911259 0.552 rs13038881 chr20:31468113 T/C cg13636640 chr20:31349939 DNMT3B -0.53 -7.32 -0.41 2.98e-12 Inflammatory bowel disease; CESC cis rs4919694 1.000 rs77318450 chr10:104733098 A/G cg04362960 chr10:104952993 NT5C2 0.7 5.52 0.32 8.1e-8 Arsenic metabolism; CESC cis rs2180341 1.000 rs2144743 chr6:127633810 A/T cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6.31e-39 Breast cancer; CESC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg08859206 chr1:53392774 SCP2 -0.68 -10.01 -0.52 3.33e-20 Monocyte count; CESC cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg00033643 chr7:134001901 SLC35B4 0.44 5.6 0.33 5.4e-8 Mean platelet volume; CESC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs3749237 0.595 rs4955412 chr3:49418168 A/C cg06212747 chr3:49208901 KLHDC8B 0.53 7.2 0.4 6.14e-12 Resting heart rate; CESC cis rs1413885 0.516 rs10789183 chr1:65856779 G/C cg14976592 chr1:65886160 LEPROT;LEPR 0.48 6.38 0.37 7.66e-10 Anticoagulant levels; CESC trans rs7263120 1.000 rs4331584 chr20:23727735 G/A cg00618312 chr13:41556559 ELF1 -0.58 -6.15 -0.35 2.87e-9 Blood protein levels; CESC cis rs12618769 0.652 rs3754871 chr2:99224309 A/T cg10123293 chr2:99228465 UNC50 0.41 5.35 0.31 1.88e-7 Bipolar disorder; CESC cis rs8044868 0.530 rs12918956 chr16:72224335 A/G cg16558253 chr16:72132732 DHX38 0.4 6.13 0.35 3.1e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7527798 0.501 rs12125256 chr1:207851361 C/T cg09232269 chr1:207846808 CR1L -0.28 -5.06 -0.3 7.78e-7 Erythrocyte sedimentation rate; CESC cis rs9486719 1.000 rs12208449 chr6:96903253 A/G cg06623918 chr6:96969491 KIAA0776 0.71 6.99 0.39 2.29e-11 Migraine;Coronary artery disease; CESC cis rs8062405 0.755 rs111693583 chr16:28583610 C/T cg07382826 chr16:28625726 SULT1A1 0.4 6.53 0.37 3.32e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9302635 0.513 rs8044555 chr16:72152755 T/C cg01557791 chr16:72042693 DHODH -0.56 -6.54 -0.37 3.07e-10 Blood protein levels; CESC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg17376030 chr22:41985996 PMM1 0.52 5.65 0.33 4.04e-8 Vitiligo; CESC cis rs6952808 0.578 rs6949478 chr7:1841342 A/G cg13880726 chr7:1868755 MAD1L1 -0.44 -5.67 -0.33 3.77e-8 Bipolar disorder and schizophrenia; CESC cis rs28719689 0.541 rs28376074 chr8:1274394 A/T cg22761795 chr8:1265118 NA 0.71 6.37 0.36 8.33e-10 Colonoscopy-negative controls vs population controls; CESC cis rs9929218 1.000 rs13334471 chr16:68800452 T/C cg02972257 chr16:68554789 NA 0.43 5.22 0.31 3.65e-7 Colorectal cancer; CESC cis rs7107174 0.892 rs2512519 chr11:77953015 C/T cg02023728 chr11:77925099 USP35 0.54 7.47 0.42 1.13e-12 Testicular germ cell tumor; CESC cis rs897080 0.515 rs786617 chr2:44593158 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.8 0.34 1.87e-8 Height; CESC cis rs1551570 0.755 rs11667630 chr19:10229297 A/C cg00593900 chr19:10206746 ANGPTL6 -0.35 -5.74 -0.33 2.64e-8 Narcolepsy; CESC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg10150615 chr22:24372951 LOC391322 -0.56 -7.73 -0.43 2.2e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10392 0.543 rs4812332 chr20:37534665 C/T cg27552599 chr20:37590471 DHX35 0.38 5.38 0.31 1.61e-7 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs2050392 0.894 rs2480277 chr10:30703513 G/T cg25182066 chr10:30743637 MAP3K8 0.39 5.15 0.3 5.1e-7 Inflammatory bowel disease; CESC cis rs7267979 0.933 rs2261109 chr20:25259200 T/C cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.14e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12792894 chr1:115123975 BCAS2 -0.54 -6.47 -0.37 4.71e-10 Gut microbiome composition (summer); CESC cis rs4319547 0.737 rs10846921 chr12:122943376 G/T cg05707623 chr12:122985044 ZCCHC8 0.52 6.5 0.37 4.08e-10 Body mass index; CESC cis rs12476592 0.602 rs10469944 chr2:63816672 C/G cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC cis rs35110281 0.807 rs9976441 chr21:45046591 G/A cg04455712 chr21:45112962 RRP1B 0.42 6.22 0.36 1.89e-9 Mean corpuscular volume; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 7.6 0.42 5.07e-13 Bipolar disorder; CESC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg03188948 chr7:1209495 NA 0.68 6.53 0.37 3.42e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg23711669 chr6:146136114 FBXO30 0.9 13.27 0.63 3.71e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs9443189 0.762 rs1321162 chr6:76456347 C/T cg01950844 chr6:76311363 SENP6 0.66 7.08 0.4 1.29e-11 Prostate cancer; CESC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs9815354 1.000 rs9874513 chr3:41909508 G/A cg03022575 chr3:42003672 ULK4 0.57 5.88 0.34 1.2e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs6752107 1.000 rs12994997 chr2:234173503 G/A cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.36 5.39 0.31 1.54e-7 Crohn's disease;Inflammatory bowel disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15092368 chr1:143270427 NA -0.41 -6.68 -0.38 1.41e-10 Gut microbiota (bacterial taxa); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25202390 chr2:99797622 MRPL30;MITD1 -0.48 -6.41 -0.37 6.48e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg18876405 chr7:65276391 NA -0.49 -6.74 -0.38 9.59e-11 Aortic root size; CESC cis rs4555082 0.874 rs28785556 chr14:105745388 A/T cg13114125 chr14:105738426 BRF1 -0.89 -10.33 -0.54 2.97e-21 Mean platelet volume;Platelet distribution width; CESC cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg12386194 chr3:101231763 SENP7 0.42 5.24 0.31 3.3e-7 Colorectal cancer; CESC cis rs1348850 0.567 rs4893838 chr2:178531436 T/C cg23306229 chr2:178417860 TTC30B 0.53 6.37 0.36 8.45e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6963495 0.818 rs73190156 chr7:105153567 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs12477438 0.677 rs12475034 chr2:99699464 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.77 -0.43 1.71e-13 Chronic sinus infection; CESC cis rs425277 0.585 rs3107143 chr1:2045372 G/C cg16545954 chr1:2118288 C1orf86 -0.32 -5.98 -0.34 7.26e-9 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13076329 chr4:114682704 CAMK2D -0.47 -6.16 -0.35 2.72e-9 Fibrinogen levels; CESC cis rs763121 0.853 rs8142098 chr22:39058757 T/G cg21395723 chr22:39101663 GTPBP1 0.43 5.37 0.31 1.74e-7 Menopause (age at onset); CESC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg04546413 chr19:29218101 NA 0.57 8.0 0.44 3.87e-14 Methadone dose in opioid dependence; CESC cis rs2439831 0.850 rs7168158 chr15:44050376 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.72 6.83 0.39 5.8200000000000003e-11 Lung cancer in ever smokers; CESC cis rs2625529 0.689 rs12050794 chr15:72169466 G/A cg16672083 chr15:72433130 SENP8 0.37 5.6 0.33 5.47e-8 Red blood cell count; CESC cis rs838147 0.505 rs1688264 chr19:49209560 T/G cg21064579 chr19:49206444 FUT2 0.51 7.12 0.4 9.95e-12 Dietary macronutrient intake; CESC cis rs9457247 1.000 rs408087 chr6:167398952 C/T cg07741184 chr6:167504864 NA 0.29 5.29 0.31 2.55e-7 Crohn's disease; CESC cis rs763121 0.853 rs4820345 chr22:39091151 T/C cg06022373 chr22:39101656 GTPBP1 0.86 12.58 0.61 8.71e-29 Menopause (age at onset); CESC cis rs1348850 0.645 rs11889272 chr2:178432378 C/T cg23306229 chr2:178417860 TTC30B 0.86 9.17 0.49 1.33e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7208859 0.623 rs216423 chr17:28942109 G/C cg13385521 chr17:29058706 SUZ12P 0.58 5.04 0.3 8.45e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs71403859 0.570 rs76231867 chr16:71449926 G/A cg08717414 chr16:71523259 ZNF19 -0.84 -8.19 -0.45 1.1e-14 Post bronchodilator FEV1; CESC cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg27266027 chr21:40555129 PSMG1 0.47 5.53 0.32 7.79e-8 Cognitive function; CESC cis rs17854409 0.764 rs73613593 chr20:61471582 T/C cg07645718 chr20:61493192 TCFL5 0.96 5.08 0.3 7.06e-7 Obesity-related traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17602823 chr1:28586543 SESN2 0.49 6.86 0.39 4.91e-11 Gut microbiota (bacterial taxa); CESC cis rs4132509 0.516 rs10927031 chr1:243685760 G/C cg21452805 chr1:244014465 NA 0.55 6.12 0.35 3.39e-9 RR interval (heart rate); CESC cis rs7937682 0.632 rs7112886 chr11:111743232 T/C cg09085632 chr11:111637200 PPP2R1B 0.86 10.86 0.55 5.71e-23 Primary sclerosing cholangitis; CESC cis rs6674176 0.660 rs11210936 chr1:44391438 A/T cg23954153 chr1:44402353 ARTN -0.35 -5.46 -0.32 1.08e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7937682 0.632 rs11214028 chr11:111761149 T/C cg09085632 chr11:111637200 PPP2R1B 0.87 11.02 0.56 1.67e-23 Primary sclerosing cholangitis; CESC cis rs11608355 0.521 rs6606706 chr12:109830173 C/T cg19025524 chr12:109796872 NA -0.54 -7.7 -0.43 2.8e-13 Neuroticism; CESC cis rs7208859 0.673 rs9895815 chr17:29138033 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs5756813 0.688 rs2413483 chr22:38127950 C/T cg19894588 chr14:64061835 NA -0.65 -7.41 -0.41 1.7e-12 Optic cup area;Vertical cup-disc ratio; CESC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.51 0.32 8.53e-8 Personality dimensions; CESC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg05863683 chr7:1912471 MAD1L1 0.42 6.21 0.36 2.09e-9 Bipolar disorder and schizophrenia; CESC cis rs6867032 1.000 rs16902318 chr5:2013568 A/G cg26168224 chr5:2018326 NA 0.91 17.91 0.74 1.45e-47 Gut microbiome composition (winter); CESC cis rs9318086 0.663 rs2312295 chr13:24457744 A/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.46 6.48 0.37 4.37e-10 Myopia (pathological); CESC cis rs4253772 0.872 rs14843 chr22:46639462 A/T cg00784671 chr22:46762841 CELSR1 -0.57 -5.61 -0.33 5.1e-8 LDL cholesterol;Cholesterol, total; CESC trans rs1493916 1.000 rs990882 chr18:31398180 T/G cg27147174 chr7:100797783 AP1S1 -0.52 -7.1 -0.4 1.14e-11 Life satisfaction; CESC cis rs9611519 1.000 rs5751069 chr22:41627775 C/G cg03806693 chr22:41940476 POLR3H -0.47 -5.2 -0.3 3.92e-7 Neuroticism; CESC cis rs10089 0.953 rs6595807 chr5:127531603 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.7 9.04 0.49 3.36e-17 Ileal carcinoids; CESC cis rs11077998 0.967 rs901373 chr17:80506559 A/G cg10255544 chr17:80519551 FOXK2 0.5 8.09 0.44 2.2e-14 Reticulocyte fraction of red cells; CESC cis rs9488822 0.676 rs4354188 chr6:116327936 T/C cg05304507 chr6:116381966 FRK 0.26 6.56 0.37 2.86e-10 Cholesterol, total;LDL cholesterol; CESC trans rs1545843 0.593 rs10746319 chr12:84783530 C/G cg03015433 chr16:56623111 MT3 0.33 6.03 0.35 5.39e-9 Major depressive disorder; CESC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg11958594 chr17:80055299 FASN -0.46 -6.04 -0.35 5.25e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs11190604 1.000 rs7088827 chr10:102303865 C/G cg07080220 chr10:102295463 HIF1AN 0.64 5.84 0.34 1.54e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7824557 0.614 rs2736286 chr8:11227104 A/G cg21775007 chr8:11205619 TDH -0.51 -7.95 -0.44 5.25e-14 Retinal vascular caliber; CESC cis rs2637266 0.678 rs2894345 chr10:78454561 A/C cg18941641 chr10:78392320 NA 0.4 7.32 0.41 2.91e-12 Pulmonary function; CESC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.43 0.32 1.27e-7 Bipolar disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13489694 chr12:96337059 AMDHD1;CCDC38 -0.45 -6.05 -0.35 4.88e-9 Gut microbiota (bacterial taxa); CESC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg11764359 chr7:65958608 NA -0.54 -7.08 -0.4 1.32e-11 Aortic root size; CESC cis rs9487051 0.676 rs7753697 chr6:109593292 A/G cg12927641 chr6:109611667 NA -0.37 -5.56 -0.32 6.55e-8 Reticulocyte fraction of red cells; CESC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg16680214 chr1:154839983 KCNN3 0.54 8.5 0.46 1.36e-15 Prostate cancer; CESC cis rs2832191 0.755 rs2832193 chr21:30493589 T/C cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.3e-20 Dental caries; CESC cis rs7500321 1.000 rs7500321 chr16:28977020 G/A cg05966235 chr16:28915196 ATP2A1 -0.37 -5.23 -0.31 3.45e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22963863 chr17:47022211 SNF8 0.61 6.81 0.39 6.47e-11 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.26 0.79 3.33e-59 Prudent dietary pattern; CESC cis rs2629540 0.781 rs11245362 chr10:126458649 T/C cg08799069 chr10:126477246 METTL10 -0.68 -9.32 -0.5 4.61e-18 Cocaine dependence; CESC cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.05 0.3 8.24e-7 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26604191 chr7:5372559 TNRC18 0.48 6.31 0.36 1.17e-9 Fibrinogen levels; CESC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg22029157 chr1:209979665 IRF6 -0.59 -9.17 -0.49 1.39e-17 Monobrow; CESC cis rs1881797 0.932 rs2387038 chr1:247674919 G/A cg05639522 chr1:247681581 NA 0.5 6.31 0.36 1.16e-9 Acute lymphoblastic leukemia (childhood); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19320564 chr1:40157253 HPCAL4 0.58 6.57 0.37 2.7e-10 Gut microbiome composition (summer); CESC cis rs921968 0.608 rs678814 chr2:219359287 T/C cg02176678 chr2:219576539 TTLL4 0.43 7.54 0.42 7.27e-13 Mean corpuscular hemoglobin concentration; CESC cis rs3733585 0.577 rs28558552 chr4:9964913 G/A cg11266682 chr4:10021025 SLC2A9 -0.58 -10.28 -0.53 4.51e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7927771 0.801 rs12798028 chr11:47604639 C/T cg18512352 chr11:47633146 NA -0.46 -7.06 -0.4 1.44e-11 Subjective well-being; CESC cis rs72781680 0.898 rs111460347 chr2:24018833 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg26782824 chr11:82867961 PCF11 -0.39 -6.08 -0.35 4.14e-9 Vertical cup-disc ratio; CESC cis rs9314323 0.729 rs7007256 chr8:26203081 G/A cg13160058 chr8:26243215 BNIP3L -0.34 -5.19 -0.3 4.21e-7 Red cell distribution width; CESC cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg12756686 chr19:29218302 NA 0.42 5.87 0.34 1.3e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs7589342 0.839 rs12997003 chr2:106436413 C/T cg16077055 chr2:106428750 NCK2 0.53 7.53 0.42 8e-13 Addiction; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19952014 chr10:3186114 PITRM1 -0.47 -6.09 -0.35 3.85e-9 Systemic lupus erythematosus; CESC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg02725872 chr8:58115012 NA -0.37 -5.61 -0.33 5.1e-8 Developmental language disorder (linguistic errors); CESC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg23758822 chr17:41437982 NA 1.01 15.76 0.7 6.41e-40 Menopause (age at onset); CESC cis rs6088580 0.634 rs3736762 chr20:33037336 C/T cg24642439 chr20:33292090 TP53INP2 0.52 6.82 0.39 6.28e-11 Glomerular filtration rate (creatinine); CESC cis rs2072499 0.750 rs909269 chr1:156192028 C/T cg24450063 chr1:156163899 SLC25A44 0.9 10.96 0.56 2.73e-23 Testicular germ cell tumor; CESC cis rs1018836 0.923 rs10956720 chr8:91576222 C/T cg16814680 chr8:91681699 NA -0.71 -10.1 -0.53 1.67e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg02931644 chr1:25747376 RHCE 0.39 6.39 0.37 7.63e-10 Erythrocyte sedimentation rate; CESC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg04369109 chr6:150039330 LATS1 -0.42 -5.81 -0.34 1.81e-8 Lung cancer; CESC cis rs2380220 0.872 rs2613529 chr6:95945036 C/T cg15832292 chr6:96025679 MANEA -0.64 -5.71 -0.33 2.99e-8 Behavioural disinhibition (generation interaction); CESC cis rs1670533 1.000 rs935970 chr4:1045323 C/G cg27284194 chr4:1044797 NA -0.49 -6.14 -0.35 3.08e-9 Recombination rate (females); CESC cis rs2180341 0.814 rs7768435 chr6:127737038 A/C cg27446573 chr6:127587934 RNF146 0.83 12.03 0.59 6.99e-27 Breast cancer; CESC cis rs3105593 0.563 rs12439561 chr15:50962156 C/T cg08437265 chr15:50716283 USP8 0.4 5.06 0.3 8.01e-7 QT interval; CESC cis rs67311347 1.000 rs2887995 chr3:40409029 C/G cg01475735 chr3:40494733 NA -0.39 -5.06 -0.3 7.93e-7 Renal cell carcinoma; CESC cis rs11642862 1.000 rs112234000 chr16:30778808 G/A cg02466173 chr16:30829666 NA -0.6 -6.08 -0.35 4.15e-9 Tonsillectomy; CESC cis rs854765 0.583 rs6502622 chr17:17834691 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.35 0.41 2.5e-12 Total body bone mineral density; CESC cis rs8114671 0.836 rs2038504 chr20:33648187 T/C cg07148914 chr20:33460835 GGT7 -0.4 -5.11 -0.3 6.21e-7 Height; CESC cis rs660498 0.507 rs4018735 chr10:27741298 T/C cg25705717 chr10:27608719 NA 0.47 5.73 0.33 2.73e-8 Asthma (childhood onset); CESC cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg19539972 chr4:7069911 GRPEL1 -0.75 -7.44 -0.42 1.43e-12 Monocyte percentage of white cells; CESC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg10691866 chr7:65817282 TPST1 0.31 5.34 0.31 2e-7 Aortic root size; CESC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg23985595 chr17:80112537 CCDC57 0.41 6.42 0.37 6.41e-10 Life satisfaction; CESC trans rs1814175 0.565 rs4881721 chr11:49761851 G/A cg03929089 chr4:120376271 NA -0.7 -8.94 -0.48 7e-17 Height; CESC trans rs17764205 0.929 rs10422137 chr19:3256521 C/T cg27384338 chr17:2031545 SMG6 -0.64 -6.08 -0.35 4.2e-9 Bipolar disorder and schizophrenia; CESC cis rs763014 0.966 rs4144003 chr16:645968 C/T cg00908189 chr16:619842 PIGQ 0.65 9.09 0.49 2.36e-17 Height; CESC trans rs1814175 0.727 rs2140597 chr11:49873946 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.98 -0.78 8.73e-55 Height; CESC cis rs7771547 0.573 rs517890 chr6:36397786 G/C cg04289385 chr6:36355825 ETV7 0.38 5.57 0.32 6.41e-8 Platelet distribution width; CESC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.6 0.33 5.36e-8 Menopause (age at onset); CESC cis rs6580649 0.941 rs1793933 chr12:48396450 G/T cg24011408 chr12:48396354 COL2A1 0.41 5.31 0.31 2.28e-7 Lung cancer; CESC cis rs6546550 0.867 rs7592647 chr2:70139134 C/T cg02498382 chr2:70120550 SNRNP27 -0.38 -6.6 -0.38 2.17e-10 Prevalent atrial fibrillation; CESC cis rs4974559 0.739 rs2335937 chr4:1321516 C/A cg02980000 chr4:1222292 CTBP1 0.81 7.22 0.41 5.48e-12 Systolic blood pressure; CESC cis rs6445797 0.632 rs7626378 chr3:56602885 A/T cg13792233 chr3:56591045 CCDC66 0.39 5.11 0.3 6.18e-7 Gastritis; CESC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs4595586 0.525 rs1878227 chr12:39355719 A/T cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.09e-8 Morning vs. evening chronotype; CESC cis rs3733585 0.673 rs6814664 chr4:9956228 C/T cg11266682 chr4:10021025 SLC2A9 -0.59 -11.16 -0.57 5.9e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs898097 0.841 rs8180 chr17:80901036 C/G cg15369054 chr17:80825471 TBCD -0.47 -6.67 -0.38 1.51e-10 Breast cancer; CESC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg11890956 chr21:40555474 PSMG1 -0.95 -15.4 -0.69 1.2e-38 Cognitive function; CESC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg23172400 chr8:95962367 TP53INP1 -0.4 -8.19 -0.45 1.12e-14 Type 2 diabetes; CESC cis rs10851478 0.708 rs11639111 chr15:49749735 C/T cg08060515 chr15:49448048 GALK2;COPS2 0.41 5.46 0.32 1.11e-7 Oral cavity cancer; CESC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg16325326 chr1:53192061 ZYG11B 0.9 16.03 0.7 7.12e-41 Monocyte count; CESC cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg04166393 chr7:2884313 GNA12 0.39 5.15 0.3 5.07e-7 Height; CESC cis rs909002 1.000 rs1474182 chr1:32136398 C/T cg13919466 chr1:32135498 COL16A1 -0.51 -9.76 -0.51 1.95e-19 Intelligence (multi-trait analysis); CESC cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg08704250 chr15:31115839 NA 0.69 9.09 0.49 2.46e-17 Huntington's disease progression; CESC cis rs4595586 0.679 rs4768471 chr12:39325960 G/A cg26384229 chr12:38710491 ALG10B 0.43 6.25 0.36 1.62e-9 Morning vs. evening chronotype; CESC cis rs7255436 1.000 rs7255436 chr19:8433196 C/A cg10174797 chr19:8464628 RAB11B 0.4 5.81 0.34 1.8e-8 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23885512 chr19:45515293 RELB -0.52 -6.37 -0.36 8.28e-10 Gut microbiome composition (summer); CESC cis rs2120019 0.938 rs8030089 chr15:75290377 C/T cg17294928 chr15:75287854 SCAMP5 -0.76 -8.91 -0.48 8.57e-17 Blood trace element (Zn levels); CESC cis rs7647973 0.626 rs9830730 chr3:49675875 G/C cg13072238 chr3:49761600 GMPPB -0.45 -5.47 -0.32 1.04e-7 Menarche (age at onset); CESC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg18876405 chr7:65276391 NA -0.51 -7.07 -0.4 1.39e-11 Aortic root size; CESC cis rs397969 0.596 rs4925064 chr17:19901405 T/C cg12073167 chr17:19770448 ULK2 -0.46 -5.28 -0.31 2.63e-7 Platelet count; CESC cis rs911555 0.504 rs4444269 chr14:104072724 G/C cg12935359 chr14:103987150 CKB -0.52 -7.55 -0.42 7.03e-13 Intelligence (multi-trait analysis); CESC cis rs244293 1.000 rs183618 chr17:53235974 C/T cg19360675 chr17:53046073 COX11;STXBP4 0.39 5.06 0.3 7.98e-7 Menarche (age at onset); CESC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs258892 0.846 rs266441 chr5:72197677 A/G cg21869765 chr5:72125136 TNPO1 0.43 5.32 0.31 2.22e-7 Small cell lung carcinoma; CESC cis rs4268898 0.717 rs3731626 chr2:24427864 G/A cg20701182 chr2:24300061 SF3B14 0.56 6.18 0.35 2.4e-9 Asthma; CESC cis rs9325144 0.581 rs2653758 chr12:38946233 G/T cg26384229 chr12:38710491 ALG10B -0.59 -9.0 -0.48 4.56e-17 Morning vs. evening chronotype; CESC cis rs11264213 0.786 rs72659677 chr1:36257353 A/T cg27506609 chr1:36549197 TEKT2 0.61 5.04 0.3 8.54e-7 Schizophrenia; CESC cis rs1371867 0.846 rs959022 chr8:101295992 T/A cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.24e-11 Atrioventricular conduction; CESC cis rs11098499 0.644 rs7676296 chr4:120555687 A/G cg09307838 chr4:120376055 NA 0.77 10.24 0.53 5.82e-21 Corneal astigmatism; CESC cis rs10129255 0.556 rs9324093 chr14:107139910 C/T cg23076370 chr14:107095027 NA -0.53 -7.36 -0.41 2.27e-12 Kawasaki disease; CESC cis rs703842 0.616 rs7489290 chr12:58228588 C/G cg00677455 chr12:58241039 CTDSP2 0.77 10.41 0.54 1.74e-21 Multiple sclerosis; CESC cis rs1559088 0.947 rs10403238 chr19:33552405 A/G cg27124370 chr19:33622961 WDR88 0.42 5.34 0.31 1.98e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs11098499 0.954 rs67265404 chr4:120359270 C/T cg25214090 chr10:38739885 LOC399744 0.71 9.89 0.52 7.9e-20 Corneal astigmatism; CESC cis rs8067545 0.611 rs7212500 chr17:20045658 A/G cg13482628 chr17:19912719 NA 0.43 5.72 0.33 2.88e-8 Schizophrenia; CESC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg13206674 chr6:150067644 NUP43 0.42 5.82 0.34 1.66e-8 Lung cancer; CESC cis rs10276381 0.579 rs73072543 chr7:28146850 A/G cg23620719 chr7:28220237 JAZF1 0.65 5.19 0.3 4.13e-7 Crohn's disease; CESC cis rs3540 0.553 rs8042861 chr15:90977333 G/T cg10434728 chr15:90938212 IQGAP1 0.38 7.02 0.4 1.82e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.78 8.21 0.45 9.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9399401 0.601 rs643975 chr6:142844251 C/G cg03128060 chr6:142623767 GPR126 -0.31 -5.24 -0.31 3.31e-7 Chronic obstructive pulmonary disease; CESC cis rs11711311 1.000 rs9811200 chr3:113531180 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.74 10.46 0.54 1.12e-21 IgG glycosylation; CESC cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg03060546 chr3:49711283 APEH 0.5 6.16 0.35 2.75e-9 Parkinson's disease; CESC cis rs7191439 0.790 rs8060966 chr16:88777329 A/G cg02389323 chr16:88786976 FAM38A 0.79 6.85 0.39 5.16e-11 Plateletcrit; CESC cis rs6740322 0.895 rs10210125 chr2:43556433 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.7 -7.43 -0.42 1.52e-12 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10957254 chr1:54411942 LRRC42;HSPB11 0.55 6.18 0.35 2.34e-9 Gut microbiome composition (summer); CESC cis rs708547 0.581 rs781661 chr4:57780307 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.51 -6.59 -0.38 2.31e-10 Response to bleomycin (chromatid breaks); CESC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg16049864 chr8:95962084 TP53INP1 -0.65 -11.4 -0.57 9.17e-25 Type 2 diabetes; CESC cis rs7914558 0.966 rs10748836 chr10:104693917 G/A cg04362960 chr10:104952993 NT5C2 0.43 5.53 0.32 7.76e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7666738 0.830 rs6819047 chr4:98866902 G/A cg03467027 chr4:99064603 C4orf37 0.42 5.16 0.3 4.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.692 rs8024476 chr15:76983954 T/C cg26408565 chr15:76604113 ETFA -0.38 -5.44 -0.32 1.2e-7 Blood metabolite levels; CESC cis rs57221529 0.545 rs55955015 chr5:575182 A/G cg16447950 chr5:562315 NA -0.64 -6.8 -0.39 7.01e-11 Lung disease severity in cystic fibrosis; CESC cis rs4718428 0.672 rs4718412 chr7:66286867 C/T cg18252515 chr7:66147081 NA 0.5 5.37 0.31 1.75e-7 Corneal structure; CESC cis rs6430585 0.528 rs895285 chr2:136710554 A/G cg07169764 chr2:136633963 MCM6 1.27 17.82 0.74 3.19e-47 Corneal structure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06111627 chr3:127309564 TPRA1 -0.61 -7.05 -0.4 1.54e-11 Gut microbiome composition (summer); CESC cis rs7917772 0.505 rs61869211 chr10:104449836 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.51 5.83 0.34 1.65e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05783302 chr2:47143505 MCFD2 0.46 6.71 0.38 1.2e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3733585 0.624 rs58130873 chr4:9972081 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.52 -0.32 8.08e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2637266 0.678 rs1797495 chr10:78577602 G/A cg18941641 chr10:78392320 NA 0.39 7.5 0.42 9.5e-13 Pulmonary function; CESC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg11764359 chr7:65958608 NA -0.79 -11.5 -0.58 4.33e-25 Aortic root size; CESC cis rs1144333 0.850 rs1146651 chr1:76273594 C/A cg22875332 chr1:76189707 ACADM -0.53 -5.15 -0.3 5.11e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs8060686 0.920 rs60769312 chr16:67732186 C/T cg26727032 chr16:67993705 SLC12A4 -0.57 -6.0 -0.35 6.41e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07697561 chr5:140998635 DIAPH1 0.55 6.41 0.37 6.61e-10 Gut microbiome composition (summer); CESC cis rs2760061 0.598 rs1774755 chr1:228115282 T/G cg01973587 chr1:228161476 NA 0.35 5.32 0.31 2.17e-7 Diastolic blood pressure; CESC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg09165964 chr15:75287851 SCAMP5 0.45 6.19 0.36 2.28e-9 Breast cancer; CESC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.93e-7 Lung cancer; CESC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg00310523 chr12:86230176 RASSF9 -0.31 -5.04 -0.3 8.55e-7 Major depressive disorder; CESC trans rs11098499 0.754 rs2036860 chr4:120248934 A/G cg25214090 chr10:38739885 LOC399744 0.62 8.71 0.47 3.41e-16 Corneal astigmatism; CESC cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg16339924 chr4:17578868 LAP3 0.73 9.53 0.51 1.03e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3749237 0.615 rs6792911 chr3:49429856 C/T cg06212747 chr3:49208901 KLHDC8B 0.5 6.82 0.39 6.12e-11 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14521523 chr1:115212675 DENND2C 0.56 6.81 0.39 6.52e-11 Gut microbiome composition (summer); CESC cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 8.43 0.46 2.18e-15 Schizophrenia; CESC cis rs9814567 0.712 rs9838119 chr3:134331980 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.1 -0.3 6.38e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg16606324 chr3:10149918 C3orf24 0.41 5.09 0.3 6.8e-7 Alzheimer's disease; CESC cis rs6088580 0.634 rs6059835 chr20:33020141 A/G cg06115741 chr20:33292138 TP53INP2 0.48 6.14 0.35 3e-9 Glomerular filtration rate (creatinine); CESC cis rs67311347 0.824 rs59922539 chr3:40337110 G/A cg24209194 chr3:40518798 ZNF619 0.44 5.51 0.32 8.39e-8 Renal cell carcinoma; CESC cis rs8020095 0.571 rs2281676 chr14:67638455 C/G cg19548862 chr14:67692701 FAM71D 0.48 5.87 0.34 1.29e-8 Depression (quantitative trait); CESC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg23708337 chr7:1209742 NA 0.55 5.42 0.32 1.33e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1707322 1.000 rs7538978 chr1:46505054 C/T cg06784218 chr1:46089804 CCDC17 -0.34 -5.86 -0.34 1.34e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9818758 0.556 rs9880309 chr3:49304329 G/C cg00383909 chr3:49044727 WDR6 0.81 6.16 0.35 2.63e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg12927641 chr6:109611667 NA -0.43 -6.75 -0.38 9.5e-11 Reticulocyte fraction of red cells; CESC cis rs2303759 0.676 rs7248378 chr19:49908144 C/A cg22307029 chr19:49891270 CCDC155 0.62 7.28 0.41 3.8e-12 Multiple sclerosis; CESC cis rs763121 0.853 rs5750621 chr22:38956166 C/T cg06544989 chr22:39130855 UNC84B 0.49 8.16 0.45 1.35e-14 Menopause (age at onset); CESC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg23281280 chr6:28129359 ZNF389 0.56 7.62 0.42 4.55e-13 Depression; CESC cis rs4523957 0.651 rs8082485 chr17:2060407 A/G cg16513277 chr17:2031491 SMG6 -0.72 -10.2 -0.53 8.12e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08730051 chr6:4018948 NA 0.58 6.24 0.36 1.69e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05157023 chr16:2027451 TBL3 -0.55 -6.8 -0.39 7.09e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 1.000 rs785470 chr1:46519622 C/A cg03146154 chr1:46216737 IPP -0.72 -9.73 -0.51 2.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4319547 0.956 rs9988963 chr12:122991478 C/G cg23029597 chr12:123009494 RSRC2 -0.48 -5.28 -0.31 2.65e-7 Body mass index; CESC cis rs11638352 1.000 rs2957581 chr15:44410082 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06203126 chr5:43313815 HMGCS1 -0.63 -7.43 -0.42 1.47e-12 Gut microbiome composition (summer); CESC cis rs6459788 0.527 rs6980250 chr7:157228710 C/T cg06271696 chr7:157225062 NA -0.48 -8.21 -0.45 9.6e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg23711669 chr6:146136114 FBXO30 0.95 12.44 0.61 2.75e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs1008375 1.000 rs2286771 chr4:17643848 G/A cg15017067 chr4:17643749 FAM184B 0.35 5.07 0.3 7.59e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4808199 0.649 rs17216693 chr19:19666574 T/C cg03709012 chr19:19516395 GATAD2A 0.99 8.48 0.46 1.56e-15 Nonalcoholic fatty liver disease; CESC cis rs6540556 0.723 rs6702301 chr1:209923154 C/T cg23920097 chr1:209922102 NA -0.36 -5.04 -0.3 8.5e-7 Red blood cell count; CESC cis rs2882667 0.858 rs11242447 chr5:138426173 T/C cg04439458 chr5:138467593 SIL1 -0.44 -6.79 -0.39 7.19e-11 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg18016565 chr1:150552671 MCL1 -0.42 -7.02 -0.4 1.89e-11 Tonsillectomy; CESC cis rs3026445 0.714 rs28764794 chr12:110843797 T/G cg12870014 chr12:110450643 ANKRD13A 0.41 5.03 0.3 9.17e-7 QT interval; CESC cis rs3733585 0.624 rs76574510 chr4:9953252 T/A cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs12410462 0.582 rs12408978 chr1:227596235 A/T cg23173402 chr1:227635558 NA -0.69 -6.57 -0.37 2.63e-10 Major depressive disorder; CESC cis rs208346 0.612 rs208356 chr7:2775825 A/T cg09658497 chr7:2847517 GNA12 0.44 6.74 0.38 9.72e-11 Loneliness (linear analysis); CESC cis rs1707322 1.000 rs7539800 chr1:46262129 C/G cg06784218 chr1:46089804 CCDC17 -0.36 -6.04 -0.35 5.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs67311347 0.866 rs56331709 chr3:40356558 A/C cg24209194 chr3:40518798 ZNF619 0.4 5.06 0.3 7.92e-7 Renal cell carcinoma; CESC cis rs17376456 0.825 rs1470150 chr5:93138654 C/T cg21475434 chr5:93447410 FAM172A -0.63 -5.93 -0.34 9.5e-9 Diabetic retinopathy; CESC cis rs7520050 0.778 rs3014218 chr1:46026328 A/C cg24296786 chr1:45957014 TESK2 0.5 6.37 0.36 8.3e-10 Red blood cell count;Reticulocyte count; CESC cis rs3106136 0.967 rs7435106 chr4:95169772 T/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.81 -0.39 6.61e-11 Capecitabine sensitivity; CESC cis rs9287719 0.967 rs6432121 chr2:10753804 G/C cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs6942756 0.806 rs2718115 chr7:128871532 A/G cg02491457 chr7:128862824 NA 0.65 9.69 0.51 3.3e-19 White matter hyperintensity burden; CESC cis rs11190604 1.000 rs3793772 chr10:102222825 A/G cg07080220 chr10:102295463 HIF1AN 0.56 5.82 0.34 1.74e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.15e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.649 rs139559 chr22:42191636 A/G cg06634786 chr22:41940651 POLR3H -0.46 -5.12 -0.3 5.88e-7 Vitiligo; CESC cis rs7615952 0.932 rs13325495 chr3:125637416 T/G cg05084668 chr3:125655381 ALG1L -0.5 -5.64 -0.33 4.29e-8 Blood pressure (smoking interaction); CESC cis rs7267979 0.934 rs4815423 chr20:25387521 A/G cg08601574 chr20:25228251 PYGB -0.37 -5.39 -0.31 1.55e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.66 6.25 0.36 1.6e-9 Lung function (FEV1/FVC); CESC cis rs17854409 0.881 rs68066790 chr20:61487150 T/A cg05147244 chr20:61493195 TCFL5 0.95 6.68 0.38 1.44e-10 Obesity-related traits; CESC cis rs9948 0.655 rs3731940 chr2:97377883 A/G cg01990225 chr2:97406019 LMAN2L 0.84 7.22 0.41 5.49e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs738322 0.967 rs133021 chr22:38573338 T/C cg17652424 chr22:38574118 PLA2G6 -0.36 -6.21 -0.36 2.05e-9 Cutaneous nevi; CESC cis rs2228479 0.867 rs11646448 chr16:89966357 A/T cg04013166 chr16:89971882 TCF25 0.72 7.22 0.41 5.46e-12 Skin colour saturation; CESC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg03576123 chr11:487126 PTDSS2 -1.08 -10.46 -0.54 1.12e-21 Body mass index; CESC cis rs9929218 1.000 rs9282650 chr16:68809640 T/A cg02972257 chr16:68554789 NA 0.43 5.12 0.3 5.89e-7 Colorectal cancer; CESC cis rs6831352 0.879 rs34360292 chr4:100051303 T/C cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs8141529 0.748 rs132528 chr22:29295898 C/T cg02153584 chr22:29168773 CCDC117 -0.58 -7.63 -0.42 4.31e-13 Lymphocyte counts; CESC cis rs2721195 0.719 rs4925812 chr8:145808035 C/T cg17328964 chr8:145687451 CYHR1 -0.44 -5.88 -0.34 1.22e-8 Age at first birth; CESC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg26939375 chr7:64535504 NA 0.65 8.76 0.47 2.34e-16 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23031969 chr7:5014415 RNF216L 0.53 6.52 0.37 3.44e-10 Gut microbiome composition (summer); CESC cis rs73110464 0.609 rs6580923 chr12:53358352 A/G cg14581129 chr12:53358946 NA -0.58 -7.83 -0.43 1.19e-13 Cancer (pleiotropy); CESC cis rs12701220 0.503 rs12702047 chr7:1132720 G/A cg23978390 chr7:1156363 C7orf50 0.58 5.12 0.3 5.78e-7 Bronchopulmonary dysplasia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01728866 chr1:43638014 WDR65;EBNA1BP2 0.62 6.39 0.37 7.52e-10 Gut microbiome composition (summer); CESC cis rs2549003 0.811 rs10072700 chr5:131816903 A/C cg21138405 chr5:131827807 IRF1 0.44 5.63 0.33 4.68e-8 Asthma (sex interaction); CESC cis rs6062302 0.522 rs3810492 chr20:62219740 G/A cg09650180 chr20:62225654 GMEB2 -0.76 -8.5 -0.46 1.43e-15 Glioblastoma; CESC cis rs6540559 0.611 rs11810817 chr1:210011747 C/G cg23283495 chr1:209979779 IRF6 0.48 5.62 0.33 4.86e-8 Cleft lip with or without cleft palate; CESC cis rs1975974 1.000 rs111981054 chr17:21725592 C/G cg18423549 chr17:21743878 NA -0.5 -6.92 -0.39 3.31e-11 Psoriasis; CESC cis rs9894429 0.683 rs112612275 chr17:79552604 C/A cg21984481 chr17:79567631 NPLOC4 0.57 9.29 0.5 5.85e-18 Eye color traits; CESC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.61 0.33 5.08e-8 Bipolar disorder; CESC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg12463550 chr7:65579703 CRCP 0.51 6.36 0.36 8.66e-10 Aortic root size; CESC trans rs9929218 0.817 rs3114400 chr16:68719430 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.84 -11.02 -0.56 1.68e-23 Colorectal cancer; CESC cis rs854765 0.583 rs6502627 chr17:17849671 C/T cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC cis rs12220238 1.000 rs7897778 chr10:75916105 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.63 6.2 0.36 2.13e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2531992 0.702 rs1045475 chr16:4015316 A/G cg05927578 chr16:4029543 ADCY9 0.46 6.1 0.35 3.72e-9 Waist circumference; CESC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.54 -0.37 3.12e-10 Depression; CESC cis rs116095464 0.510 rs7714944 chr5:231765 C/T cg10591111 chr5:226296 SDHA -0.49 -5.9 -0.34 1.14e-8 Breast cancer; CESC cis rs2718058 0.519 rs2722243 chr7:37873467 A/C cg15028436 chr7:37888078 TXNDC3 0.44 6.58 0.37 2.5e-10 Alzheimer's disease (late onset); CESC cis rs2228479 0.850 rs62056065 chr16:89905115 C/G cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs1499614 1.000 rs1267818 chr7:66107024 C/T cg18252515 chr7:66147081 NA -1.4 -14.2 -0.66 2.03e-34 Gout; CESC cis rs870825 0.616 rs28620459 chr4:185627132 G/C cg04058563 chr4:185651563 MLF1IP 0.65 7.08 0.4 1.31e-11 Blood protein levels; CESC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg18230493 chr5:56204884 C5orf35 0.8 9.57 0.51 8.02e-19 Initial pursuit acceleration; CESC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.5 -6.66 -0.38 1.53e-10 Menarche (age at onset); CESC cis rs7746199 0.736 rs34573979 chr6:27480526 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.87 6.22 0.36 1.96e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg09509183 chr1:209979624 IRF6 0.45 5.61 0.33 5.18e-8 Cleft lip with or without cleft palate; CESC cis rs11640533 0.901 rs11862250 chr16:53415038 C/A cg09744766 chr16:53407421 NA 0.41 5.32 0.31 2.24e-7 Intelligence (multi-trait analysis); CESC cis rs262150 0.659 rs2527237 chr7:158798494 A/G cg19418458 chr7:158789849 NA 0.5 8.02 0.44 3.42e-14 Facial morphology (factor 20); CESC cis rs4409675 0.548 rs1000432 chr1:28225119 T/C cg23691781 chr1:28212827 C1orf38 0.28 5.64 0.33 4.46e-8 Corneal astigmatism; CESC cis rs7746199 0.736 rs34573979 chr6:27480526 C/T cg18032046 chr6:28092343 ZSCAN16 -0.73 -5.08 -0.3 6.98e-7 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.62 8.39 0.46 2.99e-15 Menopause (age at onset); CESC cis rs7107356 1 rs7107356 chr11:47676170 A/G cg18512352 chr11:47633146 NA 0.41 6.43 0.37 5.94e-10 Neuroticism;Neuroticism (multi-trait analysis); CESC cis rs2115630 0.691 rs61322921 chr15:85163638 T/C cg11189052 chr15:85197271 WDR73 -0.46 -6.15 -0.35 2.77e-9 P wave terminal force; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg06134974 chr12:51477539 CSRNP2 0.46 6.16 0.35 2.76e-9 Breast cancer;Type 2 diabetes; CESC trans rs561341 0.709 rs8068049 chr17:30183857 T/C cg27661571 chr11:113659931 NA 0.68 6.13 0.35 3.22e-9 Hip circumference adjusted for BMI; CESC cis rs910316 0.935 rs175422 chr14:75627319 T/A cg08847533 chr14:75593920 NEK9 -0.97 -17.65 -0.74 1.22e-46 Height; CESC trans rs7246657 0.941 rs7256130 chr19:37933981 T/C cg01833234 chr11:6592585 DNHD1 0.52 6.03 0.35 5.4e-9 Coronary artery calcification; CESC cis rs10781543 0.845 rs36066734 chr9:139340351 A/G cg14169450 chr9:139327907 INPP5E 0.52 7.91 0.44 7.04e-14 Monocyte percentage of white cells; CESC cis rs910316 0.763 rs175057 chr14:75489632 C/T cg16144293 chr14:75469539 EIF2B2 0.41 5.27 0.31 2.83e-7 Height; CESC cis rs10791097 1.000 rs10791097 chr11:130718630 G/T cg14779329 chr11:130786720 SNX19 -0.39 -6.02 -0.35 5.8e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs12579753 0.810 rs1922565 chr12:82135348 T/C cg23701643 chr12:82153290 PPFIA2 -0.33 -5.03 -0.3 9.06e-7 Resting heart rate; CESC cis rs7605827 0.930 rs11691286 chr2:15558580 G/T cg19274914 chr2:15703543 NA 0.36 6.56 0.37 2.83e-10 Educational attainment (years of education); CESC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg04772025 chr11:68637568 NA 0.53 6.44 0.37 5.59e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs12144309 0.554 rs1217375 chr1:114346904 G/A cg13572289 chr1:114447746 DCLRE1B;AP4B1 0.46 5.42 0.32 1.36e-7 Coronary artery disease; CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg18402987 chr7:1209562 NA 0.6 7.02 0.4 1.87e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6598163 0.517 rs10902453 chr12:132297091 G/T cg10319629 chr12:132285459 NA -0.39 -5.32 -0.31 2.25e-7 Migraine; CESC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg12963246 chr6:28129442 ZNF389 0.59 7.68 0.43 3e-13 Depression; CESC cis rs2708240 1.000 rs2710102 chr7:147574390 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.23e-8 QT interval (drug interaction); CESC cis rs709400 0.663 rs62007683 chr14:103894071 G/T cg12935359 chr14:103987150 CKB -0.56 -8.22 -0.45 8.94e-15 Body mass index; CESC cis rs41563 0.607 rs6955349 chr7:104601236 G/A cg04380332 chr7:105027541 SRPK2 -0.38 -5.49 -0.32 9.44e-8 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17098829 chr15:71056133 UACA 0.58 6.92 0.39 3.36e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00560722 chr10:101989177 CHUK 0.65 7.43 0.42 1.51e-12 Gut microbiome composition (summer); CESC cis rs4566357 0.615 rs12328878 chr2:227918962 G/A cg05526886 chr2:227700861 RHBDD1 -0.55 -6.97 -0.39 2.59e-11 Coronary artery disease; CESC cis rs863345 0.565 rs7549123 chr1:158444920 A/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.69 -0.38 1.29e-10 Pneumococcal bacteremia; CESC cis rs9303280 0.806 rs13380815 chr17:38027583 A/G cg20243544 chr17:37824526 PNMT 0.5 6.43 0.37 5.86e-10 Self-reported allergy; CESC cis rs7144547 0.803 rs8008602 chr14:81890171 T/A cg02996355 chr14:81879375 NA -0.89 -10.05 -0.53 2.48e-20 Prudent dietary pattern; CESC cis rs79349575 0.716 rs595767 chr17:46957987 A/G cg16584676 chr17:46985605 UBE2Z 0.54 6.51 0.37 3.67e-10 Type 2 diabetes; CESC cis rs7267979 1.000 rs7020 chr20:25278600 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.06 0.72 1.54e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs7129220 0.588 rs7950718 chr11:10086624 C/A cg01453529 chr11:10209919 SBF2 -0.47 -5.31 -0.31 2.32e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12344046 chr22:30819716 SEC14L2 0.57 6.77 0.38 8.43e-11 Gut microbiome composition (summer); CESC cis rs3806843 0.966 rs7737424 chr5:140146345 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.37 -5.03 -0.3 9.19e-7 Depressive symptoms (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21041512 chr17:79196677 AZI1 -0.37 -6.02 -0.35 5.78e-9 Gambling; CESC cis rs2243480 1.000 rs73150014 chr7:65450919 A/C cg18252515 chr7:66147081 NA -1.21 -11.82 -0.59 3.44e-26 Diabetic kidney disease; CESC trans rs1993709 0.558 rs2821248 chr1:72575560 A/G cg01017228 chr4:745235 PCGF3 0.66 6.06 0.35 4.72e-9 Obesity (early onset extreme); CESC cis rs11997175 0.600 rs6468188 chr8:33639478 T/C ch.8.33884649F chr8:33765107 NA 0.55 6.88 0.39 4.24e-11 Body mass index; CESC cis rs34779708 0.966 rs10508816 chr10:35459976 G/A cg03585969 chr10:35415529 CREM 0.77 10.23 0.53 6.59e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs7208859 0.623 rs9911784 chr17:29124580 A/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1707322 1.000 rs11211223 chr1:46380605 C/T cg03146154 chr1:46216737 IPP 0.75 10.26 0.53 5.08e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1322639 0.614 rs9455889 chr6:169566087 A/T cg03254818 chr6:169586852 NA 0.51 5.51 0.32 8.35e-8 Pulse pressure; CESC cis rs3857536 0.813 rs2188589 chr6:66939570 C/T cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg27343303 chr11:34380546 NA 0.45 6.07 0.35 4.39e-9 Systemic lupus erythematosus; CESC cis rs870825 0.616 rs56232457 chr4:185628153 T/G cg04058563 chr4:185651563 MLF1IP 0.64 7.03 0.4 1.8e-11 Blood protein levels; CESC cis rs79387448 0.638 rs76255660 chr2:103091028 T/C cg09003973 chr2:102972529 NA 0.9 7.15 0.4 8.25e-12 Gut microbiota (bacterial taxa); CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.82 -12.18 -0.6 2.07e-27 Prudent dietary pattern; CESC cis rs1371867 0.846 rs1788205 chr8:101306546 G/C cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.24e-11 Atrioventricular conduction; CESC cis rs9811920 0.609 rs812657 chr3:99566329 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.51 -6.18 -0.35 2.42e-9 Axial length; CESC cis rs1008375 0.966 rs12509962 chr4:17680292 G/A cg02297831 chr4:17616191 MED28 0.45 5.76 0.33 2.32e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6120849 0.663 rs6119548 chr20:33552612 A/G cg24642439 chr20:33292090 TP53INP2 0.69 6.9 0.39 3.78e-11 Protein C levels; CESC cis rs727505 0.954 rs28728448 chr7:124532938 T/A cg23710748 chr7:124431027 NA -0.46 -7.24 -0.41 4.98e-12 Lewy body disease; CESC cis rs7267979 1.000 rs6115182 chr20:25410259 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -18.04 -0.74 5.11e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs7336332 0.598 rs9581850 chr13:28012265 A/G cg01674679 chr13:27998804 GTF3A -0.58 -5.34 -0.31 2.04e-7 Weight; CESC cis rs7095944 0.585 rs7080838 chr10:126419841 A/G cg08799069 chr10:126477246 METTL10 0.44 6.64 0.38 1.82e-10 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07972541 chr16:28961971 NFATC2IP 0.6 7.33 0.41 2.81e-12 Gut microbiome composition (summer); CESC cis rs6598955 0.724 rs884533 chr1:26585657 G/T cg00852783 chr1:26633632 UBXN11 0.42 6.1 0.35 3.84e-9 Obesity-related traits; CESC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.78 10.22 0.53 6.76e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04683551 chr10:14880332 HSPA14;CDNF 0.47 6.51 0.37 3.65e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2243480 1.000 rs186378 chr7:65582058 A/C cg13147721 chr7:65941812 NA -0.99 -9.36 -0.5 3.5e-18 Diabetic kidney disease; CESC cis rs4919087 0.962 rs10882883 chr10:99013312 A/G cg25902810 chr10:99078978 FRAT1 0.66 9.41 0.5 2.54e-18 Monocyte count; CESC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg04944784 chr2:26401820 FAM59B -0.7 -8.09 -0.45 2.12e-14 Gut microbiome composition (summer); CESC cis rs2200578 1.000 rs62153845 chr2:99887162 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.48 5.05 0.3 8.33e-7 IgG glycosylation; CESC cis rs9303401 0.538 rs2240258 chr17:56458183 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.91 9.5 0.5 1.27e-18 Cognitive test performance; CESC cis rs4654899 0.601 rs6668094 chr1:21464387 C/T cg05370193 chr1:21551575 ECE1 -0.36 -5.32 -0.31 2.25e-7 Superior frontal gyrus grey matter volume; CESC cis rs10493773 0.609 rs11161651 chr1:86177816 A/G cg17807903 chr1:86174739 ZNHIT6 -0.44 -6.59 -0.38 2.4e-10 Urate levels in overweight individuals; CESC cis rs835154 1.000 rs835154 chr5:14876569 A/G cg18064842 chr5:14874549 NA 0.37 5.57 0.32 6.33e-8 Blood metabolite levels; CESC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg17971929 chr21:40555470 PSMG1 -0.54 -6.88 -0.39 4.3e-11 Menarche (age at onset); CESC cis rs12586317 0.547 rs74462850 chr14:35500093 G/T cg16230307 chr14:35515116 FAM177A1 0.99 10.61 0.55 3.72e-22 Psoriasis; CESC cis rs34779708 0.931 rs7099593 chr10:35366878 A/C cg03585969 chr10:35415529 CREM 0.76 10.09 0.53 1.8e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs2629540 0.889 rs4962699 chr10:126477209 A/G cg08799069 chr10:126477246 METTL10 -0.7 -9.66 -0.51 4.21e-19 Cocaine dependence; CESC cis rs4132509 1.000 rs320320 chr1:243835186 A/G cg21452805 chr1:244014465 NA 0.46 5.6 0.33 5.3e-8 RR interval (heart rate); CESC cis rs2404602 0.655 rs10444809 chr15:77124536 G/C cg23625390 chr15:77176239 SCAPER -0.37 -5.15 -0.3 5.01e-7 Blood metabolite levels; CESC cis rs933688 0.938 rs12110065 chr5:90718474 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 13.37 0.63 1.64e-31 Smoking behavior; CESC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg03806693 chr22:41940476 POLR3H 1.18 13.5 0.64 5.99e-32 Vitiligo; CESC cis rs1044826 0.642 rs167187 chr3:139237008 C/T cg15131784 chr3:139108705 COPB2 -0.42 -5.14 -0.3 5.4e-7 Obesity-related traits; CESC cis rs796364 0.951 rs2881593 chr2:201000347 A/G cg23649088 chr2:200775458 C2orf69 -0.56 -6.0 -0.35 6.5e-9 Schizophrenia; CESC cis rs897984 0.568 rs72799330 chr16:30893555 C/A cg02466173 chr16:30829666 NA -0.48 -6.87 -0.39 4.61e-11 Dementia with Lewy bodies; CESC cis rs7937682 0.564 rs1944114 chr11:111366460 T/C cg09085632 chr11:111637200 PPP2R1B 0.46 5.41 0.32 1.4e-7 Primary sclerosing cholangitis; CESC cis rs6840258 1.000 rs17012234 chr4:87911691 A/C cg08197287 chr4:87952173 AFF1 0.42 5.79 0.33 2.01e-8 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs6088580 0.634 rs6059897 chr20:33113224 A/G cg08999081 chr20:33150536 PIGU 0.66 11.53 0.58 3.26e-25 Glomerular filtration rate (creatinine); CESC cis rs10504229 0.817 rs58957714 chr8:58195864 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -10.82 -0.55 7.5e-23 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg07691484 chr11:842764 TSPAN4;POLR2L -0.66 -8.65 -0.47 4.99e-16 Mean platelet volume; CESC cis rs58235267 0.543 rs2539990 chr2:63170185 C/T cg17519650 chr2:63277830 OTX1 0.57 8.0 0.44 3.82e-14 Prostate-specific antigen levels (conditioned on lead SNPs); CESC cis rs11252926 0.550 rs10795122 chr10:466830 C/T cg18196295 chr10:418757 DIP2C 0.5 6.67 0.38 1.53e-10 Psychosis in Alzheimer's disease; CESC cis rs10504073 0.584 rs72641612 chr8:49947986 C/T cg00325661 chr8:49890786 NA 0.58 8.73 0.47 3.01e-16 Blood metabolite ratios; CESC cis rs7208859 0.673 rs9889968 chr17:29220128 C/A cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs9951602 0.512 rs1599634 chr18:76643645 T/C cg02800362 chr5:177631904 HNRNPAB 0.62 8.1 0.45 1.96e-14 Obesity-related traits; CESC cis rs4253772 0.530 rs9627387 chr22:46684678 A/G cg07012999 chr22:46692446 CN5H6.4;GTSE1 0.54 5.67 0.33 3.74e-8 LDL cholesterol;Cholesterol, total; CESC cis rs57244997 0.556 rs73030428 chr6:162437606 T/C cg17173639 chr6:162384350 PARK2 -0.55 -5.99 -0.35 6.73e-9 Mosquito bite size; CESC cis rs2354432 0.556 rs6593777 chr1:146884013 C/G cg25205988 chr1:146714368 CHD1L 1.02 8.94 0.48 6.66e-17 Mitochondrial DNA levels; CESC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg03806693 chr22:41940476 POLR3H 1.19 14.07 0.65 6.09e-34 Crohn's disease;Inflammatory bowel disease; CESC cis rs8067354 0.645 rs2645491 chr17:57877049 C/T cg13753209 chr17:57696993 CLTC 0.66 8.34 0.46 4.12e-15 Hemoglobin concentration; CESC cis rs5769765 0.955 rs8135816 chr22:50291976 G/C cg26441486 chr22:50317300 CRELD2 0.39 5.37 0.31 1.76e-7 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19310307 chr4:174291107 SAP30 -0.44 -6.73 -0.38 1.05e-10 Gambling; CESC cis rs17641971 0.645 rs186891 chr8:50038758 T/C cg00325661 chr8:49890786 NA 0.38 5.14 0.3 5.44e-7 Blood metabolite levels; CESC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg18876405 chr7:65276391 NA -0.53 -7.22 -0.41 5.6e-12 Aortic root size; CESC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.68 -0.33 3.49e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs7672720 chr4:98938760 A/T cg05340658 chr4:99064831 C4orf37 0.82 12.48 0.61 1.93e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6088580 0.542 rs6059882 chr20:33090167 T/C cg08999081 chr20:33150536 PIGU 0.66 11.53 0.58 3.26e-25 Glomerular filtration rate (creatinine); CESC cis rs3092073 0.624 rs34293711 chr20:44587186 C/T cg27529037 chr20:44575021 PCIF1 0.58 9.02 0.48 3.96e-17 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23879496 chr6:43749477 VEGFA 0.45 6.28 0.36 1.36e-9 Fibrinogen levels; CESC trans rs1814175 0.645 rs847627 chr11:49927177 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs3820068 0.608 rs10927831 chr1:16028373 T/G cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.64e-7 Systolic blood pressure; CESC trans rs10463316 0.894 rs6875014 chr5:150754345 C/T cg24389359 chr12:111284228 CCDC63 -0.34 -6.13 -0.35 3.25e-9 Metabolite levels (Pyroglutamine); CESC cis rs7903847 0.596 rs10786340 chr10:99156563 G/C cg20016023 chr10:99160130 RRP12 -0.3 -5.19 -0.3 4.18e-7 Granulocyte percentage of myeloid white cells; CESC cis rs3096299 0.967 rs2911253 chr16:89488587 T/G cg00750074 chr16:89608354 SPG7 -0.38 -5.55 -0.32 7.08e-8 Multiple myeloma (IgH translocation); CESC cis rs35110281 0.837 rs7279968 chr21:45077398 C/G cg04455712 chr21:45112962 RRP1B 0.4 5.98 0.34 7.33e-9 Mean corpuscular volume; CESC cis rs911555 0.723 rs6575982 chr14:103862681 G/A cg24130564 chr14:104152367 KLC1 0.47 6.05 0.35 4.98e-9 Intelligence (multi-trait analysis); CESC cis rs8062405 0.755 rs17707300 chr16:28593347 A/G cg07382826 chr16:28625726 SULT1A1 0.41 6.75 0.38 9.08e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06814102 chr11:64880135 TM7SF2 -0.44 -6.06 -0.35 4.54e-9 Asthma; CESC cis rs854765 0.718 rs12943500 chr17:17790588 C/T cg16928487 chr17:17741425 SREBF1 0.57 9.44 0.5 2.03e-18 Total body bone mineral density; CESC cis rs6430585 0.591 rs77096272 chr2:136663605 C/A cg07169764 chr2:136633963 MCM6 1.23 16.56 0.71 8.67e-43 Corneal structure; CESC cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.91 9.03 0.49 3.55e-17 Schizophrenia; CESC cis rs12711979 0.765 rs6705742 chr2:3820672 C/T cg17052675 chr2:3827356 NA -0.41 -6.41 -0.37 6.5e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs9400271 0.504 rs9784763 chr6:109624937 A/G cg01475377 chr6:109611718 NA 0.41 6.12 0.35 3.29e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC trans rs9834373 0.573 rs4680931 chr3:78524616 T/G cg21593409 chr16:88706389 IL17C -0.42 -6.04 -0.35 5.2e-9 Protein quantitative trait loci; CESC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg19729930 chr2:74357872 NA 0.85 12.96 0.62 4.55e-30 Gestational age at birth (maternal effect); CESC cis rs9611565 0.921 rs3927 chr22:41722864 A/G cg03806693 chr22:41940476 POLR3H -0.91 -10.36 -0.54 2.4e-21 Vitiligo; CESC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg22535103 chr8:58192502 C8orf71 -0.68 -7.48 -0.42 1.12e-12 Developmental language disorder (linguistic errors); CESC cis rs870825 0.655 rs67798981 chr4:185619567 A/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs2979489 0.891 rs2979508 chr8:30388444 C/T cg26383811 chr8:30366931 RBPMS -0.78 -9.93 -0.52 5.94e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg02951883 chr7:2050386 MAD1L1 -0.51 -6.57 -0.37 2.72e-10 Bipolar disorder and schizophrenia; CESC cis rs35110281 0.600 rs914198 chr21:45117456 A/C cg04455712 chr21:45112962 RRP1B 0.47 7.13 0.4 9.39e-12 Mean corpuscular volume; CESC cis rs2980436 1 rs2980436 chr8:8092025 A/G cg15556689 chr8:8085844 FLJ10661 -0.67 -8.21 -0.45 9.5e-15 Schizophrenia; CESC cis rs709400 0.663 rs62007719 chr14:103943130 G/T cg12935359 chr14:103987150 CKB -0.57 -8.39 -0.46 2.88e-15 Body mass index; CESC cis rs4604732 0.631 rs1106720 chr1:247624681 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.18 0.53 9.01e-21 Mean platelet volume; CESC cis rs13082711 0.911 rs34981505 chr3:27437322 A/T cg02860705 chr3:27208620 NA 0.5 6.18 0.35 2.41e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 -0.43 -6.4 -0.37 6.89e-10 IgG glycosylation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12149777 chr4:139937459 CCRN4L 0.44 6.07 0.35 4.43e-9 Gut microbiota (bacterial taxa); CESC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.58 -0.37 2.43e-10 Life satisfaction; CESC trans rs2018683 1.000 rs2018683 chr7:29014195 G/T cg19402173 chr7:128379420 CALU -0.64 -8.7 -0.47 3.59e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.08 -13.11 -0.63 1.34e-30 Gut microbiome composition (summer); CESC cis rs9815354 0.812 rs17283677 chr3:41926148 C/T cg03022575 chr3:42003672 ULK4 -0.58 -5.41 -0.32 1.38e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg03676636 chr4:99064102 C4orf37 0.34 5.15 0.3 5e-7 Colonoscopy-negative controls vs population controls; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01911186 chr12:12765398 CREBL2 -0.48 -6.6 -0.38 2.26e-10 Height; CESC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg23758822 chr17:41437982 NA 1.02 15.6 0.69 2.35e-39 Menopause (age at onset); CESC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.73 0.33 2.78e-8 Personality dimensions; CESC cis rs796364 0.806 rs11679676 chr2:201040981 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.9 -7.12 -0.4 1.02e-11 Schizophrenia; CESC cis rs68170813 0.559 rs60255281 chr7:106963913 C/T cg02696742 chr7:106810147 HBP1 -0.57 -5.42 -0.32 1.37e-7 Coronary artery disease; CESC cis rs8077577 0.945 rs8065026 chr17:18046290 A/G cg16794390 chr17:18148240 FLII 0.46 6.28 0.36 1.38e-9 Obesity-related traits; CESC cis rs12360000 0.897 rs7921481 chr10:1898756 A/C cg26364871 chr10:1889757 NA 0.43 6.15 0.35 2.91e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs921968 0.643 rs4674305 chr2:219293326 C/T cg02176678 chr2:219576539 TTLL4 0.39 6.71 0.38 1.18e-10 Mean corpuscular hemoglobin concentration; CESC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg20503657 chr10:835505 NA 0.74 6.69 0.38 1.28e-10 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19933320 chr7:64125401 ZNF107 -0.64 -7.5 -0.42 9.76e-13 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg22143856 chr6:28129313 ZNF389 0.52 6.6 0.38 2.24e-10 Depression; CESC cis rs2749592 0.550 rs7917262 chr10:37874602 A/C cg25427524 chr10:38739819 LOC399744 0.55 7.64 0.43 3.88e-13 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs3857067 0.967 rs1472984 chr4:95036553 T/A cg11021082 chr4:95130006 SMARCAD1 -0.51 -7.74 -0.43 2.04e-13 QT interval; CESC cis rs9788721 1.000 rs931794 chr15:78826180 G/A cg18825076 chr15:78729989 IREB2 0.37 5.13 0.3 5.7e-7 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CESC cis rs6484504 0.532 rs1475558 chr11:31263428 A/G cg14844989 chr11:31128820 NA -0.39 -5.59 -0.33 5.5e-8 Red blood cell count; CESC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Depression; CESC cis rs5167 0.504 rs3760628 chr19:45457225 G/A cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.23e-14 Blood protein levels; CESC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.53 -8.2 -0.45 1.08e-14 IgG glycosylation; CESC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.67 -0.33 3.8e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs3820068 0.529 rs79570154 chr1:15990912 T/C cg18133145 chr1:16060689 PLEKHM2 -0.4 -5.11 -0.3 6.13e-7 Systolic blood pressure; CESC cis rs2180341 0.920 rs6906717 chr6:127596782 C/A cg24812749 chr6:127587940 RNF146 1.06 15.23 0.68 4.52e-38 Breast cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg24243429 chr4:148653539 ARHGAP10 0.47 6.2 0.36 2.17e-9 Systemic lupus erythematosus; CESC cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg06766960 chr11:133703094 NA -0.38 -5.42 -0.32 1.35e-7 Childhood ear infection; CESC trans rs4596713 0.539 rs953812 chr9:71787631 T/C cg16512924 chr15:28394682 HERC2 0.48 6.1 0.35 3.69e-9 Headache; CESC cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.86 -0.39 4.72e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs829883 0.724 rs11109507 chr12:98904160 C/T cg25150519 chr12:98850993 NA 0.63 7.79 0.43 1.5700000000000001e-13 Colorectal adenoma (advanced); CESC cis rs2439831 0.867 rs2470134 chr15:43849886 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.7 -8.47 -0.46 1.67e-15 Lung cancer in ever smokers; CESC cis rs7980687 0.678 rs7132277 chr12:123593382 C/T cg00376283 chr12:123451042 ABCB9 -0.68 -7.17 -0.4 7.5e-12 Height;Educational attainment;Head circumference (infant); CESC cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg03060546 chr3:49711283 APEH 0.53 6.39 0.37 7.49e-10 Parkinson's disease; CESC cis rs8038465 0.622 rs17185294 chr15:73858415 C/T cg15420318 chr15:73925796 NPTN -0.4 -5.61 -0.33 5.19e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs1814175 0.645 rs11040661 chr11:49952146 G/T cg15704280 chr7:45808275 SEPT13 -0.98 -18.56 -0.75 7.41e-50 Height; CESC cis rs2425143 1.000 rs28685274 chr20:34358527 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.72 6.82 0.39 6.12e-11 Blood protein levels; CESC cis rs208520 0.690 rs12197578 chr6:66725905 C/T cg07460842 chr6:66804631 NA 0.96 12.77 0.62 2e-29 Exhaled nitric oxide output; CESC cis rs8060686 0.641 rs9932251 chr16:68131732 G/A cg26727032 chr16:67993705 SLC12A4 -0.52 -6.3 -0.36 1.24e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.6 0.47 7.18e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg17372223 chr3:52568218 NT5DC2 0.4 6.1 0.35 3.72e-9 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19947233 chr4:90032727 TIGD2 -0.49 -6.28 -0.36 1.35e-9 Fibrinogen levels; CESC cis rs7666738 0.830 rs7659593 chr4:98934823 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs34734847 0.787 rs695949 chr12:121149736 A/G cg21892295 chr12:121157589 UNC119B -0.36 -5.86 -0.34 1.35e-8 Mean corpuscular volume; CESC cis rs2455799 0.613 rs2470549 chr3:15737698 T/C cg09340198 chr3:15902540 ANKRD28 -0.32 -5.11 -0.3 6.05e-7 Mean platelet volume; CESC cis rs11098499 0.863 rs10019674 chr4:120443489 C/T cg09307838 chr4:120376055 NA -0.85 -11.41 -0.57 8.22e-25 Corneal astigmatism; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03664992 chr1:39957393 BMP8A 0.46 6.01 0.35 6.03e-9 Systemic lupus erythematosus; CESC cis rs752010 1.000 rs2077172 chr1:42093340 A/G cg06885757 chr1:42089581 HIVEP3 0.49 8.15 0.45 1.5e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs7772486 0.790 rs2253307 chr6:146196181 T/G cg05347473 chr6:146136440 FBXO30 0.58 7.45 0.42 1.31e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg25072359 chr17:41440525 NA 0.46 6.14 0.35 2.95e-9 Menopause (age at onset); CESC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg10053473 chr17:62856997 LRRC37A3 -0.65 -8.98 -0.48 5.21e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6032067 0.929 rs35475980 chr20:43821080 A/T cg10761708 chr20:43804764 PI3 0.53 6.36 0.36 8.83e-10 Blood protein levels; CESC cis rs637571 0.558 rs10896064 chr11:65641033 G/C cg04055107 chr11:65626734 MUS81;CFL1 -0.73 -9.4 -0.5 2.71e-18 Eosinophil percentage of white cells; CESC cis rs3540 0.574 rs2256388 chr15:90969335 A/C cg10434728 chr15:90938212 IQGAP1 -0.41 -7.42 -0.41 1.62e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs698833 0.788 rs1142523 chr2:44545576 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.54 6.67 0.38 1.47e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9584850 0.834 rs9584854 chr13:99118590 C/T cg20750642 chr13:99100586 FARP1 -0.39 -5.87 -0.34 1.27e-8 Neuroticism; CESC cis rs3824867 0.920 rs3740684 chr11:47468820 C/T cg20307385 chr11:47447363 PSMC3 0.49 5.97 0.34 7.78e-9 Mean corpuscular hemoglobin; CESC cis rs1927790 0.648 rs2389631 chr13:96932868 A/C cg02571835 chr13:96230311 CLDN10 -0.35 -5.3 -0.31 2.43e-7 Body mass index; CESC cis rs2637266 0.935 rs12772269 chr10:78394292 C/A cg18941641 chr10:78392320 NA 0.45 8.6 0.47 6.93e-16 Pulmonary function; CESC cis rs17572109 0.666 rs11696005 chr2:219229641 T/C cg00012203 chr2:219082015 ARPC2 -0.52 -5.38 -0.31 1.67e-7 Platelet count;Platelet distribution width;Mean platelet volume; CESC cis rs9929218 0.871 rs1862748 chr16:68832943 C/T cg02972257 chr16:68554789 NA 0.5 5.9 0.34 1.14e-8 Colorectal cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22856972 chr6:134275178 TBPL1 -0.52 -7.05 -0.4 1.51e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs854765 0.506 rs7210400 chr17:17949957 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.55 -7.27 -0.41 4.15e-12 Total body bone mineral density; CESC cis rs6540556 0.954 rs643118 chr1:209934841 C/T cg23920097 chr1:209922102 NA -0.38 -5.69 -0.33 3.39e-8 Red blood cell count; CESC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg07395648 chr5:131743802 NA 0.42 5.46 0.32 1.09e-7 Blood metabolite levels; CESC cis rs7216064 0.953 rs8073510 chr17:65839210 A/G cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.73e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs8114671 0.836 rs745849 chr20:33572178 G/A cg07148914 chr20:33460835 GGT7 -0.42 -5.41 -0.32 1.41e-7 Height; CESC cis rs17376456 0.877 rs9314100 chr5:93447394 T/C cg21475434 chr5:93447410 FAM172A 0.9 7.81 0.43 1.31e-13 Diabetic retinopathy; CESC cis rs1008375 0.933 rs4698637 chr4:17632843 A/T cg16339924 chr4:17578868 LAP3 0.65 8.2 0.45 1.07e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2228479 0.850 rs17232630 chr16:89851179 C/T cg06558623 chr16:89946397 TCF25 1.18 9.42 0.5 2.3e-18 Skin colour saturation; CESC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg26408565 chr15:76604113 ETFA -0.4 -5.93 -0.34 9.36e-9 Blood metabolite levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20899383 chr2:176046573 ATP5G3 -0.49 -6.46 -0.37 5.09e-10 Height; CESC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg16325326 chr1:53192061 ZYG11B 0.72 10.81 0.55 8.67e-23 Monocyte count; CESC cis rs919433 0.963 rs4850787 chr2:198181750 G/A cg03934865 chr2:198174659 NA -0.44 -6.18 -0.36 2.35e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7916697 0.520 rs12246624 chr10:70036562 C/T cg06988349 chr10:69991859 ATOH7 0.34 5.29 0.31 2.6e-7 Optic disc area; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24156905 chr11:6440470 APBB1 -0.42 -6.13 -0.35 3.19e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs629535 0.814 rs488231 chr8:70064993 T/C cg21567404 chr3:27674614 NA 0.88 10.43 0.54 1.5e-21 Dupuytren's disease; CESC cis rs73001065 0.636 rs11668104 chr19:19426181 G/A cg03709012 chr19:19516395 GATAD2A 0.9 6.75 0.38 9.08e-11 LDL cholesterol; CESC trans rs55704346 0.536 rs10005866 chr4:25394900 T/G cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs11711311 1.000 rs9288982 chr3:113470149 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.67 9.01 0.48 4.07e-17 IgG glycosylation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04671591 chr1:147400503 GPR89B 0.43 6.02 0.35 5.8e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6894249 0.874 rs11745587 chr5:131796922 A/G cg21138405 chr5:131827807 IRF1 -0.31 -5.08 -0.3 7.05e-7 Asthma; CESC cis rs6754311 0.773 rs309180 chr2:136614255 A/G cg07169764 chr2:136633963 MCM6 0.69 8.48 0.46 1.62e-15 Mosquito bite size; CESC cis rs6695640 0.756 rs1555661 chr1:17730812 A/G cg01904812 chr1:17746340 RCC2 0.35 5.19 0.3 4.15e-7 Mean platelet volume; CESC cis rs13088281 1.000 rs13088281 chr3:53147576 A/C cg07884673 chr3:53033167 SFMBT1 -0.61 -5.34 -0.31 1.97e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs763121 0.853 rs2281020 chr22:39064406 A/G cg06022373 chr22:39101656 GTPBP1 0.88 13.95 0.65 1.51e-33 Menopause (age at onset); CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.47 -6.26 -0.36 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs5753618 0.583 rs9606839 chr22:31802710 A/C cg13145458 chr22:31556086 RNF185 -0.49 -5.83 -0.34 1.62e-8 Colorectal cancer; CESC trans rs7746199 0.668 rs34864796 chr6:27459923 G/A cg06606381 chr12:133084897 FBRSL1 -1.07 -8.79 -0.48 1.92e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg18876405 chr7:65276391 NA -0.59 -7.87 -0.44 9.35e-14 Aortic root size; CESC cis rs875971 0.867 rs13227219 chr7:65844062 T/A cg11764359 chr7:65958608 NA 0.96 15.02 0.68 2.67e-37 Aortic root size; CESC cis rs9457247 0.967 rs382009 chr6:167403121 G/C cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.27e-8 Crohn's disease; CESC cis rs7937682 0.575 rs7950926 chr11:111776437 G/C cg09085632 chr11:111637200 PPP2R1B 0.87 11.86 0.59 2.58e-26 Primary sclerosing cholangitis; CESC cis rs506597 0.525 rs3757859 chr7:100241163 A/C cg10426581 chr7:100472382 SRRT 0.59 5.07 0.3 7.37e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs6570726 0.526 rs9376934 chr6:145738702 A/G cg23711669 chr6:146136114 FBXO30 0.55 7.29 0.41 3.54e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.935 rs449377 chr6:145852437 C/G cg05347473 chr6:146136440 FBXO30 0.49 6.76 0.38 8.85e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs3820928 0.874 rs4675128 chr2:227814757 T/C cg11843606 chr2:227700838 RHBDD1 -0.48 -6.38 -0.37 7.64e-10 Pulmonary function; CESC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.41e-28 Prudent dietary pattern; CESC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg19163074 chr7:65112434 INTS4L2 0.41 5.21 0.3 3.75e-7 Aortic root size; CESC cis rs1538970 0.924 rs11211111 chr1:45908782 C/T cg24296786 chr1:45957014 TESK2 -0.46 -5.25 -0.31 3.14e-7 Platelet count; CESC cis rs7216064 0.953 rs58141639 chr17:65864902 C/T cg12091567 chr17:66097778 LOC651250 -0.85 -8.7 -0.47 3.61e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9527 0.590 rs10883818 chr10:104759586 A/G cg04362960 chr10:104952993 NT5C2 0.42 5.31 0.31 2.33e-7 Arsenic metabolism; CESC cis rs7726839 0.561 rs72703044 chr5:579737 G/A cg16447950 chr5:562315 NA -0.58 -6.74 -0.38 9.99e-11 Obesity-related traits; CESC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs55788414 0.932 rs7185658 chr16:81189336 A/G cg06400318 chr16:81190750 PKD1L2 -0.6 -6.7 -0.38 1.24e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs2011503 1.000 rs16996127 chr19:19627310 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 5.09 0.3 6.7e-7 Bipolar disorder; CESC cis rs3820928 1.000 rs10193316 chr2:227777650 A/G cg05526886 chr2:227700861 RHBDD1 -0.44 -5.8 -0.34 1.92e-8 Pulmonary function; CESC cis rs2011503 1.000 rs76095338 chr19:19633908 G/A cg11584989 chr19:19387371 SF4 0.61 7.03 0.4 1.79e-11 Bipolar disorder; CESC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.45 0.8 7.14e-60 Prudent dietary pattern; CESC cis rs910316 0.737 rs108622 chr14:75481908 A/G cg08847533 chr14:75593920 NEK9 -0.9 -15.43 -0.69 9.04e-39 Height; CESC cis rs4604732 0.631 rs12038880 chr1:247624603 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 6.43 0.37 5.79e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs913655 0.688 rs12220519 chr10:19020881 C/T cg11356571 chr19:48219924 EHD2 0.53 6.0 0.35 6.29e-9 Gestational age at birth in premature rupture of membrane-initiated deliveries (maternal effect); CESC cis rs12912251 0.948 rs34281605 chr15:38989674 G/A cg01338139 chr15:38987640 C15orf53 -0.46 -5.27 -0.31 2.89e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs2191566 0.845 rs7258517 chr19:44535999 G/T cg20607764 chr19:44506953 ZNF230 -0.59 -7.45 -0.42 1.28e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs11098499 0.863 rs1552092 chr4:120488496 C/T cg24375607 chr4:120327624 NA 0.45 5.54 0.32 7.33e-8 Corneal astigmatism; CESC cis rs73206853 0.563 rs7960749 chr12:111164369 T/C cg12870014 chr12:110450643 ANKRD13A 0.64 5.66 0.33 3.91e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2204008 0.580 rs1315373 chr12:38179114 T/G cg26384229 chr12:38710491 ALG10B -0.4 -5.34 -0.31 1.96e-7 Bladder cancer; CESC cis rs9916302 0.904 rs12450559 chr17:37694709 G/A cg00129232 chr17:37814104 STARD3 -0.57 -7.53 -0.42 7.83e-13 Glomerular filtration rate (creatinine); CESC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg08859206 chr1:53392774 SCP2 -0.72 -10.12 -0.53 1.47e-20 Monocyte count; CESC cis rs7909791 0.632 rs3818278 chr10:105665323 G/T cg24587175 chr10:105670608 OBFC1 0.45 6.27 0.36 1.46e-9 White matter hyperintensity burden; CESC cis rs149163995 1 rs149163995 chr2:203777226 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Migraine; CESC cis rs2742234 0.590 rs2075912 chr10:43622217 T/C cg15436174 chr10:43711423 RASGEF1A -0.46 -5.4 -0.31 1.51e-7 Hirschsprung disease; CESC cis rs10791323 0.593 rs11223599 chr11:133717902 A/T cg15485101 chr11:133734466 NA -0.33 -5.49 -0.32 9.19e-8 Childhood ear infection; CESC cis rs911555 0.755 rs2756132 chr14:103967820 C/G cg24130564 chr14:104152367 KLC1 0.46 6.08 0.35 4.23e-9 Intelligence (multi-trait analysis); CESC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.1 -0.35 3.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs3780486 0.801 rs3780495 chr9:33125942 A/C cg20290983 chr6:43655470 MRPS18A 0.98 18.02 0.74 6.31e-48 IgG glycosylation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17025142 chr5:99871651 FAM174A -0.45 -6.2 -0.36 2.11e-9 Gut microbiota (bacterial taxa); CESC cis rs7429990 0.965 rs319684 chr3:47932274 C/T cg11946769 chr3:48343235 NME6 0.42 5.11 0.3 6.05e-7 Educational attainment (years of education); CESC cis rs12477438 0.798 rs6716913 chr2:99580641 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.22 -0.53 6.79e-21 Chronic sinus infection; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21897413 chr5:176944084 DDX41 -0.54 -6.56 -0.37 2.84e-10 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22396454 chr6:42896723 CNPY3 -0.57 -6.84 -0.39 5.56e-11 Gut microbiome composition (summer); CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg10255097 chr10:114711603 TCF7L2 -0.55 -6.33 -0.36 1.03e-9 Gut microbiota (bacterial taxa); CESC cis rs1008375 1.000 rs28501187 chr4:17643620 G/A cg15017067 chr4:17643749 FAM184B 0.36 5.11 0.3 6.3e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10754283 0.557 rs1215508 chr1:90088697 C/T cg21401794 chr1:90099060 LRRC8C 0.56 7.86 0.43 9.83e-14 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6772849 1.000 rs2712373 chr3:128308055 T/C cg16766828 chr3:128327626 NA -0.31 -5.06 -0.3 7.77e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs9309473 1.000 rs7586463 chr2:73798476 T/C cg20560298 chr2:73613845 ALMS1 -0.54 -7.03 -0.4 1.7e-11 Metabolite levels; CESC trans rs11992162 0.560 rs13276386 chr8:11797421 T/A cg15556689 chr8:8085844 FLJ10661 0.51 6.35 0.36 9.34e-10 Monocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07791476 chr4:8456156 C4orf23 -0.45 -6.33 -0.36 1.03e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs67311347 1.000 rs11714912 chr3:40494065 A/G cg09455208 chr3:40491958 NA -0.43 -7.39 -0.41 1.88e-12 Renal cell carcinoma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11698762 chr2:74648964 WDR54 -0.46 -6.65 -0.38 1.67e-10 Gambling; CESC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg04169830 chr2:88471460 THNSL2 0.33 5.09 0.3 6.64e-7 Response to metformin (IC50); CESC cis rs7927771 1.000 rs12361031 chr11:47783076 G/A cg05585544 chr11:47624801 NA -0.5 -7.88 -0.44 8.28e-14 Subjective well-being; CESC cis rs34330 0.562 rs11055023 chr12:12853197 A/G cg04607235 chr12:12878440 APOLD1 -0.85 -9.22 -0.49 9.72e-18 Systemic lupus erythematosus; CESC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.04 0.4 1.65e-11 Tonsillectomy; CESC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg27535305 chr1:53392650 SCP2 -0.33 -5.38 -0.31 1.62e-7 Monocyte count; CESC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg07414643 chr4:187882934 NA 0.53 7.2 0.4 6.04e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01151424 chr11:17411006 KCNJ11 0.59 6.84 0.39 5.57e-11 Gut microbiome composition (summer); CESC cis rs72781680 0.611 rs72783625 chr2:24315540 C/T cg08917208 chr2:24149416 ATAD2B 0.55 5.3 0.31 2.47e-7 Lymphocyte counts; CESC cis rs2014572 0.967 rs10427146 chr19:57755998 T/C cg12963866 chr19:57752005 ZNF805 -0.49 -6.49 -0.37 4.09e-10 Hyperactive-impulsive symptoms; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03724728 chr17:38231199 THRA -0.36 -6.22 -0.36 1.92e-9 Gambling; CESC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg19468946 chr17:37922297 IKZF3 -0.39 -5.06 -0.3 7.91e-7 Glomerular filtration rate (creatinine); CESC cis rs4704187 0.687 rs115403098 chr5:74397384 A/G cg03227963 chr5:74354835 NA 0.32 5.92 0.34 9.97e-9 Response to amphetamines; CESC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg21782813 chr7:2030301 MAD1L1 0.45 6.34 0.36 1.01e-9 Bipolar disorder and schizophrenia; CESC cis rs67311347 0.824 rs73073561 chr3:40357298 G/T cg09455208 chr3:40491958 NA 0.45 7.44 0.42 1.42e-12 Renal cell carcinoma; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02614658 chr16:476729 RAB11FIP3 0.44 6.05 0.35 4.8e-9 Systemic lupus erythematosus; CESC cis rs636291 0.517 rs670666 chr1:10549380 C/T cg20482658 chr1:10539492 PEX14 0.27 5.71 0.33 3.04e-8 Prostate cancer; CESC cis rs7927592 1.000 rs7927592 chr11:68369960 G/A cg16797656 chr11:68205561 LRP5 0.39 5.42 0.32 1.33e-7 Total body bone mineral density; CESC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg18876405 chr7:65276391 NA -0.52 -7.19 -0.4 6.73e-12 Aortic root size; CESC cis rs2228479 0.867 rs12930056 chr16:89946649 C/A cg04013166 chr16:89971882 TCF25 0.77 7.14 0.4 8.86e-12 Skin colour saturation; CESC cis rs614226 1.000 rs1167727 chr12:120965508 C/A cg01236616 chr12:121019343 POP5 1.55 19.98 0.78 8.29e-55 Type 1 diabetes nephropathy; CESC cis rs9303401 0.659 rs72828726 chr17:56951217 C/G cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.52 0.61 1.4e-28 Cognitive test performance; CESC cis rs6674176 0.628 rs2301993 chr1:44426025 G/A cg12908607 chr1:44402522 ARTN -0.46 -6.61 -0.38 2.08e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9640161 0.659 rs11975886 chr7:150010362 G/A cg10018233 chr7:150070692 REPIN1 0.46 7.32 0.41 2.89e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs4132509 0.793 rs7538011 chr1:243703344 A/G cg21452805 chr1:244014465 NA 0.61 6.57 0.37 2.65e-10 RR interval (heart rate); CESC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg21194808 chr1:2205498 SKI -0.33 -5.1 -0.3 6.36e-7 Height; CESC cis rs9911578 0.835 rs1990008 chr17:56459408 C/G cg05425664 chr17:57184151 TRIM37 0.47 6.48 0.37 4.34e-10 Intelligence (multi-trait analysis); CESC cis rs12190007 0.517 rs3006183 chr6:169808263 T/C cg15038512 chr6:170123185 PHF10 -0.48 -6.81 -0.39 6.6e-11 Obesity-related traits; CESC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg12463550 chr7:65579703 CRCP -0.49 -6.14 -0.35 2.95e-9 Aortic root size; CESC cis rs7429990 0.965 rs7430913 chr3:48032357 G/T cg11946769 chr3:48343235 NME6 -0.44 -5.42 -0.32 1.36e-7 Educational attainment (years of education); CESC cis rs72781680 0.898 rs17762609 chr2:24114729 G/T cg08917208 chr2:24149416 ATAD2B 0.93 8.63 0.47 5.68e-16 Lymphocyte counts; CESC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg10351095 chr21:47802916 PCNT 0.49 6.73 0.38 1.02e-10 Testicular germ cell tumor; CESC cis rs523522 0.962 rs4767914 chr12:120993817 C/T cg12219531 chr12:120966889 COQ5 0.74 9.75 0.51 2.17e-19 High light scatter reticulocyte count; CESC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.76 6.69 0.38 1.3e-10 Platelet count; CESC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.49 6.96 0.39 2.69e-11 Bipolar disorder; CESC trans rs561341 0.882 rs2521594 chr17:30302087 C/T cg20587970 chr11:113659929 NA -1.41 -18.23 -0.75 1.08e-48 Hip circumference adjusted for BMI; CESC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg19163074 chr7:65112434 INTS4L2 0.4 5.03 0.3 8.98e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07097265 chr17:17727093 SREBF1 0.52 6.18 0.35 2.45e-9 Gut microbiome composition (summer); CESC cis rs4722166 0.630 rs10950916 chr7:22799667 C/T cg05472934 chr7:22766657 IL6 0.87 10.63 0.55 3.14e-22 Lung cancer; CESC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg05025164 chr4:1340916 KIAA1530 0.52 7.3 0.41 3.26e-12 Longevity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13686143 chr2:201828163 ORC2L 0.54 7.01 0.4 1.93e-11 Gut microbiota (bacterial taxa); CESC trans rs3008706 0.850 rs2987037 chr9:15997752 C/A cg09705784 chr17:76565232 DNAH17 0.58 6.04 0.35 5.09e-9 Bilirubin levels; CESC cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg27347728 chr4:17578864 LAP3 0.43 5.22 0.31 3.57e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2066819 0.818 rs703830 chr12:56701872 T/C cg26714650 chr12:56694279 CS 1.28 15.86 0.7 2.7e-40 Psoriasis vulgaris; CESC trans rs11098499 0.743 rs10003567 chr4:120241674 C/T cg25214090 chr10:38739885 LOC399744 0.61 8.47 0.46 1.73e-15 Corneal astigmatism; CESC cis rs2439831 0.850 rs28707214 chr15:44131623 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.43 0.42 1.45e-12 Lung cancer in ever smokers; CESC cis rs2243480 1.000 rs160643 chr7:65558222 C/T cg12463550 chr7:65579703 CRCP 0.69 5.58 0.32 6e-8 Diabetic kidney disease; CESC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg00074818 chr8:8560427 CLDN23 0.36 5.3 0.31 2.42e-7 Obesity-related traits; CESC cis rs7188697 0.809 rs4784956 chr16:58596291 A/C cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg05255149 chr17:80675120 FN3KRP -0.47 -5.45 -0.32 1.13e-7 Breast cancer; CESC cis rs7084402 0.902 rs3001715 chr10:60285509 A/G cg07615347 chr10:60278583 BICC1 0.61 9.69 0.51 3.28e-19 Refractive error; CESC cis rs854765 0.619 rs1101727 chr17:18016148 T/C cg09796270 chr17:17721594 SREBF1 0.39 5.21 0.3 3.86e-7 Total body bone mineral density; CESC cis rs611744 0.647 rs7015240 chr8:109262204 G/A cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.65e-8 Dupuytren's disease; CESC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9790314 1.000 rs336567 chr3:161073046 A/G cg04691961 chr3:161091175 C3orf57 -0.4 -5.04 -0.3 8.47e-7 Morning vs. evening chronotype; CESC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg02375832 chr11:62437615 C11orf48 -0.37 -5.13 -0.3 5.56e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg11663144 chr21:46675770 NA -0.64 -10.05 -0.53 2.42e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg04414720 chr1:150670196 GOLPH3L 0.52 6.88 0.39 4.32e-11 Melanoma; CESC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.39e-20 Developmental language disorder (linguistic errors); CESC cis rs9911578 1.000 rs9898916 chr17:57048660 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -6.96 -0.39 2.66e-11 Intelligence (multi-trait analysis); CESC cis rs2380220 0.576 rs4368819 chr6:96031109 T/G cg15832292 chr6:96025679 MANEA 0.74 7.81 0.43 1.37e-13 Behavioural disinhibition (generation interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10551016 chr22:41252963 ST13;XPNPEP3 0.45 6.31 0.36 1.2e-9 Gut microbiota (bacterial taxa); CESC cis rs7772486 0.748 rs2748484 chr6:146333653 C/T cg05347473 chr6:146136440 FBXO30 0.48 6.35 0.36 9.54e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20877507 chr13:50464614 LOC220429 -0.54 -6.29 -0.36 1.28e-9 Gut microbiome composition (summer); CESC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.18 0.4 7.21e-12 Height; CESC cis rs7829975 0.623 rs7010753 chr8:8373956 A/G cg15556689 chr8:8085844 FLJ10661 0.5 6.2 0.36 2.21e-9 Mood instability; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01133655 chr6:3140601 BPHL 0.45 6.44 0.37 5.67e-10 Fibrinogen levels; CESC cis rs6912958 0.535 rs1753154 chr6:88032843 G/C cg08069147 chr6:88032118 GJB7;C6orf162 0.79 11.96 0.59 1.16e-26 Monocyte percentage of white cells; CESC cis rs8002861 0.664 rs2325089 chr13:44450222 C/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.39 -5.13 -0.3 5.48e-7 Leprosy; CESC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.48 -0.37 4.36e-10 Depression; CESC cis rs8060686 0.641 rs16957696 chr16:68039850 C/T cg26727032 chr16:67993705 SLC12A4 -0.54 -6.15 -0.35 2.78e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05627390 chr13:108871167 ABHD13;LIG4 0.49 6.31 0.36 1.15e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10751667 1.000 rs10902246 chr11:953674 T/C cg01483505 chr11:975446 AP2A2 0.39 5.24 0.31 3.32e-7 Alzheimer's disease (late onset); CESC cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg22862634 chr11:62369728 EML3;MTA2 0.59 8.23 0.45 8.31e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.07 18.23 0.75 1.15e-48 Height; CESC cis rs9300255 0.679 rs4759409 chr12:123719585 G/C cg00376283 chr12:123451042 ABCB9 0.72 8.81 0.48 1.66e-16 Neutrophil percentage of white cells; CESC cis rs4319547 0.695 rs11836188 chr12:122865507 T/C cg05707623 chr12:122985044 ZCCHC8 0.53 5.91 0.34 1.06e-8 Body mass index; CESC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 8.02 0.44 3.31e-14 Platelet count; CESC cis rs10791097 0.694 rs7940027 chr11:130745591 A/G cg12179176 chr11:130786555 SNX19 0.64 9.87 0.52 8.97e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11190604 1.000 rs11816840 chr10:102309220 G/C cg07080220 chr10:102295463 HIF1AN 0.66 6.08 0.35 4.13e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs7635838 0.892 rs9310384 chr3:11491980 A/G cg00170343 chr3:11313890 ATG7 0.44 6.06 0.35 4.77e-9 HDL cholesterol; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16097330 chr5:171615472 STK10 0.47 6.18 0.35 2.43e-9 Systemic lupus erythematosus; CESC cis rs6598955 0.671 rs17162105 chr1:26591255 A/G cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC cis rs2204008 0.539 rs1283295 chr12:38146014 A/C cg26384229 chr12:38710491 ALG10B -0.41 -5.67 -0.33 3.66e-8 Bladder cancer; CESC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.95 9.59 0.51 7e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9911578 0.967 rs8072712 chr17:57162464 A/T cg12560992 chr17:57184187 TRIM37 1.01 17.93 0.74 1.24e-47 Intelligence (multi-trait analysis); CESC cis rs6120849 0.617 rs12480442 chr20:33648388 C/G cg24642439 chr20:33292090 TP53INP2 0.68 6.81 0.39 6.42e-11 Protein C levels; CESC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg11494091 chr17:61959527 GH2 0.72 12.16 0.6 2.58e-27 Prudent dietary pattern; CESC trans rs2797160 0.935 rs926855 chr6:126021782 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.16 0.35 2.67e-9 Endometrial cancer; CESC cis rs4595586 0.545 rs1588970 chr12:39403122 C/A cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs7940866 0.834 rs2324315 chr11:130839772 C/G cg12179176 chr11:130786555 SNX19 0.65 10.02 0.52 3.01e-20 Schizophrenia; CESC cis rs2243480 1.000 rs2420170 chr7:65656053 T/C cg13147721 chr7:65941812 NA 0.97 9.16 0.49 1.47e-17 Diabetic kidney disease; CESC cis rs478304 0.627 rs11604568 chr11:65511336 G/A cg10518572 chr11:65560635 OVOL1 -0.32 -6.53 -0.37 3.33e-10 Acne (severe); CESC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3096299 0.967 rs753853 chr16:89446525 G/T cg00750074 chr16:89608354 SPG7 -0.39 -5.38 -0.31 1.65e-7 Multiple myeloma (IgH translocation); CESC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg08859206 chr1:53392774 SCP2 0.56 7.35 0.41 2.41e-12 Monocyte count; CESC cis rs2997447 0.595 rs3008425 chr1:26385660 T/C cg19633962 chr1:26362018 EXTL1 -0.49 -5.15 -0.3 5.03e-7 QRS complex (12-leadsum); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04911280 chr6:44281184 AARS2 0.67 7.7 0.43 2.72e-13 Gut microbiome composition (summer); CESC cis rs67478160 0.643 rs7147171 chr14:104264857 G/A cg08213375 chr14:104286397 PPP1R13B 0.54 10.8 0.55 8.68e-23 Schizophrenia; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg04078658 chr7:2054064 MAD1L1 -0.43 -6.16 -0.35 2.73e-9 Bronchopulmonary dysplasia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01571169 chr16:87367721 FBXO31 -0.6 -6.42 -0.37 6.15e-10 Gut microbiome composition (summer); CESC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg04369109 chr6:150039330 LATS1 -0.39 -5.35 -0.31 1.93e-7 Lung cancer; CESC cis rs11122272 0.766 rs2790870 chr1:231543823 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -7.97 -0.44 4.66e-14 Hemoglobin concentration; CESC cis rs7296418 0.663 rs11057284 chr12:123830692 G/C cg05973401 chr12:123451056 ABCB9 0.42 5.32 0.31 2.16e-7 Platelet count; CESC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg08470875 chr2:26401718 FAM59B 0.75 7.79 0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs12474201 0.928 rs17822019 chr2:46934505 T/C cg06386533 chr2:46925753 SOCS5 0.92 12.64 0.61 5.7e-29 Height; CESC cis rs12960472 0.577 rs7228682 chr18:52398155 C/A cg12377874 chr18:52495404 RAB27B -0.34 -5.08 -0.3 7.2e-7 Positive affect; CESC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg13114125 chr14:105738426 BRF1 -0.75 -9.72 -0.51 2.62e-19 Mean platelet volume;Platelet distribution width; CESC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg06456125 chr7:65229604 NA -0.38 -5.15 -0.3 4.99e-7 Calcium levels; CESC cis rs1050631 0.960 rs4799848 chr18:33686292 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.42 5.44 0.32 1.22e-7 Esophageal squamous cell cancer (length of survival); CESC cis rs910316 0.763 rs175490 chr14:75545685 A/G cg16144293 chr14:75469539 EIF2B2 -0.39 -5.15 -0.3 5.08e-7 Height; CESC cis rs2760061 0.784 rs708116 chr1:228198196 C/A cg18477163 chr1:228402036 OBSCN 0.32 5.62 0.33 4.75e-8 Diastolic blood pressure; CESC cis rs10504229 0.906 rs2270607 chr8:58194699 A/G cg05313129 chr8:58192883 C8orf71 -0.45 -5.41 -0.32 1.43e-7 Developmental language disorder (linguistic errors); CESC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg11987759 chr7:65425863 GUSB -0.48 -6.57 -0.37 2.58e-10 Calcium levels; CESC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg19046167 chr17:80928561 B3GNTL1 0.48 5.85 0.34 1.43e-8 Glycated hemoglobin levels; CESC cis rs4955124 0.558 rs77566631 chr3:32018805 C/T cg05935571 chr3:32023257 ZNF860;OSBPL10 0.97 8.8 0.48 1.83e-16 Schizophrenia; CESC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg11644478 chr21:40555479 PSMG1 0.83 12.79 0.62 1.73e-29 Cognitive function; CESC cis rs4242434 0.927 rs7843828 chr8:22463623 C/T cg03733263 chr8:22462867 KIAA1967 0.95 15.11 0.68 1.22e-37 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs4141404 0.673 rs1968023 chr22:31942770 A/G cg13145458 chr22:31556086 RNF185 0.54 5.95 0.34 8.53e-9 Paclitaxel-induced neuropathy; CESC cis rs8114671 0.562 rs6088640 chr20:33472509 C/T cg07148914 chr20:33460835 GGT7 0.46 6.11 0.35 3.46e-9 Height; CESC cis rs4891159 0.548 rs689902 chr18:74119969 C/T cg24786174 chr18:74118243 ZNF516 -0.85 -16.91 -0.72 5.11e-44 Longevity; CESC cis rs854765 0.693 rs35451946 chr17:17764061 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.53 -7.64 -0.42 3.91e-13 Total body bone mineral density; CESC cis rs9640161 0.871 rs56156367 chr7:150047201 A/T cg27494647 chr7:150038898 RARRES2 0.41 5.04 0.3 8.48e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs7647973 0.925 rs6446257 chr3:49253492 A/G cg06212747 chr3:49208901 KLHDC8B -0.56 -6.7 -0.38 1.22e-10 Menarche (age at onset); CESC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg00166722 chr3:10149974 C3orf24 0.46 5.81 0.34 1.83e-8 Alzheimer's disease; CESC cis rs2066819 1.000 rs2643623 chr12:56689725 G/C cg26734620 chr12:56694298 CS -0.93 -9.55 -0.51 9.4e-19 Psoriasis vulgaris; CESC cis rs7927771 0.965 rs35985502 chr11:47847428 G/A cg05585544 chr11:47624801 NA -0.49 -7.71 -0.43 2.62e-13 Subjective well-being; CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.37 -5.44 -0.32 1.2e-7 Bipolar disorder; CESC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 13.15 0.63 1e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2243480 1.000 rs316330 chr7:65605372 C/A cg12463550 chr7:65579703 CRCP 0.75 5.84 0.34 1.56e-8 Diabetic kidney disease; CESC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg25767906 chr1:53392781 SCP2 0.43 5.85 0.34 1.42e-8 Monocyte count; CESC cis rs10899021 0.790 rs11236180 chr11:74342928 A/G cg25880958 chr11:74394337 NA -0.74 -7.86 -0.43 9.76e-14 Response to metformin (IC50); CESC cis rs4919087 1.000 rs10786326 chr10:99070377 G/A cg25902810 chr10:99078978 FRAT1 0.72 10.73 0.55 1.48e-22 Monocyte count; CESC cis rs6674176 0.561 rs12127226 chr1:44395309 C/T cg13606994 chr1:44402422 ARTN -0.41 -6.27 -0.36 1.44e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg07507251 chr3:52567010 NT5DC2 0.34 5.73 0.33 2.73e-8 Intelligence (multi-trait analysis); CESC trans rs1814175 0.527 rs3974435 chr11:49619533 G/A cg15704280 chr7:45808275 SEPT13 -0.84 -10.44 -0.54 1.37e-21 Height; CESC cis rs4631830 0.869 rs4131357 chr10:51537292 C/A cg16070123 chr10:51489643 NA -0.34 -5.07 -0.3 7.4e-7 Prostate-specific antigen levels; CESC cis rs10927875 0.619 rs7537101 chr1:16150384 T/C cg21385522 chr1:16154831 NA -0.74 -10.42 -0.54 1.52e-21 Dilated cardiomyopathy; CESC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg18337363 chr3:52569053 NT5DC2 0.3 5.12 0.3 5.78e-7 Bipolar disorder; CESC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg17372223 chr3:52568218 NT5DC2 0.4 6.08 0.35 4.1e-9 Electroencephalogram traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15890103 chr11:86663160 FZD4 -0.38 -6.9 -0.39 3.72e-11 Gambling; CESC cis rs4268898 0.760 rs7597919 chr2:24563646 A/G cg06627628 chr2:24431161 ITSN2 0.56 7.13 0.4 9.38e-12 Asthma; CESC cis rs10743315 0.557 rs17271690 chr12:19450236 A/G cg02471346 chr12:19282374 PLEKHA5 0.78 5.68 0.33 3.49e-8 Gut microbiota (bacterial taxa); CESC trans rs10510102 0.748 rs11200297 chr10:123732431 A/G cg14125468 chr9:132113996 NA -0.56 -6.03 -0.35 5.57e-9 Breast cancer; CESC cis rs77106637 1.000 rs76793820 chr11:72619860 G/A cg04827223 chr11:72435913 ARAP1 -0.55 -5.72 -0.33 2.8e-8 Type 2 diabetes; CESC cis rs7680126 0.596 rs10939723 chr4:10139105 G/T cg00071950 chr4:10020882 SLC2A9 -0.46 -5.36 -0.31 1.82e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg05555928 chr11:63887634 MACROD1 0.36 5.46 0.32 1.07e-7 Platelet count; CESC cis rs73001065 0.818 rs16996185 chr19:19720788 G/T cg03709012 chr19:19516395 GATAD2A -0.91 -7.1 -0.4 1.14e-11 LDL cholesterol; CESC cis rs17376456 0.741 rs10036829 chr5:93309897 G/C cg21475434 chr5:93447410 FAM172A 0.76 6.88 0.39 4.31e-11 Diabetic retinopathy; CESC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.89e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs829883 0.664 rs829874 chr12:98840615 G/A cg25150519 chr12:98850993 NA 0.87 14.71 0.67 3.18e-36 Colorectal adenoma (advanced); CESC cis rs2295359 0.892 rs6688383 chr1:67655954 C/T cg17031739 chr1:67600172 NA -0.42 -5.51 -0.32 8.32e-8 Psoriasis; CESC cis rs56104184 0.775 rs117744769 chr19:49402686 G/T cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg19536664 chr17:6899085 ALOX12 -0.37 -7.72 -0.43 2.37e-13 Tonsillectomy; CESC cis rs28374715 0.662 rs72737793 chr15:41516823 C/T cg18705301 chr15:41695430 NDUFAF1 -0.8 -10.11 -0.53 1.59e-20 Ulcerative colitis; CESC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg23281280 chr6:28129359 ZNF389 0.4 5.61 0.33 5.2100000000000003e-08 Cardiac Troponin-T levels; CESC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg13944838 chr5:179740914 GFPT2 -0.62 -8.31 -0.45 5.16e-15 Height; CESC cis rs11630290 0.592 rs11071767 chr15:64154635 A/G cg12036633 chr15:63758958 NA -0.43 -5.29 -0.31 2.52e-7 Iris characteristics; CESC cis rs8067545 0.611 rs1974745 chr17:20059824 C/G cg13482628 chr17:19912719 NA 0.41 5.45 0.32 1.17e-7 Schizophrenia; CESC cis rs933688 1.000 rs2839728 chr5:90727412 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.08 13.6 0.64 2.51e-32 Smoking behavior; CESC cis rs6032067 0.929 rs6017503 chr20:43815103 G/A cg10761708 chr20:43804764 PI3 0.53 6.38 0.36 7.98e-10 Blood protein levels; CESC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg02951883 chr7:2050386 MAD1L1 -0.48 -6.21 -0.36 2.04e-9 Bipolar disorder and schizophrenia; CESC cis rs1707322 0.716 rs6694889 chr1:46101806 A/C cg06784218 chr1:46089804 CCDC17 0.4 6.99 0.39 2.23e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs72945132 0.660 rs12292191 chr11:70122426 T/C cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs3008870 0.709 rs62883160 chr1:67392889 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.64 8.32 0.45 4.78e-15 Lymphocyte percentage of white cells; CESC cis rs13385 0.769 rs4912707 chr5:139624461 A/G cg26211634 chr5:139558579 C5orf32 0.49 5.24 0.31 3.26e-7 Atrial fibrillation; CESC cis rs28489187 0.660 rs6576767 chr1:85876316 G/A cg16011679 chr1:85725395 C1orf52 -0.46 -5.51 -0.32 8.69e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs1707322 0.717 rs3014237 chr1:46090252 A/G cg05343316 chr1:45956843 TESK2 -0.53 -6.44 -0.37 5.64e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs589448 1.000 rs589448 chr12:69752200 A/G cg14784868 chr12:69753453 YEATS4 0.91 14.57 0.67 1.05e-35 Cerebrospinal fluid biomarker levels; CESC cis rs10744422 0.800 rs2343110 chr12:123343571 T/G cg25930673 chr12:123319894 HIP1R -0.81 -6.32 -0.36 1.09e-9 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05031202 chr17:7738649 NA 0.45 6.15 0.35 2.92e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2637266 0.703 rs7086368 chr10:78489041 A/G cg18941641 chr10:78392320 NA 0.4 7.68 0.43 3.08e-13 Pulmonary function; CESC cis rs7542091 0.704 rs12022221 chr1:210046178 A/C cg21951975 chr1:209979733 IRF6 0.47 8.32 0.46 4.66e-15 Monobrow; CESC cis rs11098499 0.908 rs9995234 chr4:120321827 A/G cg24375607 chr4:120327624 NA 0.46 5.48 0.32 9.93e-8 Corneal astigmatism; CESC cis rs854765 0.547 rs2955380 chr17:17944349 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.33 -0.36 1.03e-9 Total body bone mineral density; CESC cis rs2439831 0.850 rs28509275 chr15:44098105 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.66 5.44 0.32 1.22e-7 Lung cancer in ever smokers; CESC cis rs35110281 0.807 rs2838325 chr21:45014284 A/T cg04455712 chr21:45112962 RRP1B -0.42 -6.69 -0.38 1.33e-10 Mean corpuscular volume; CESC cis rs652260 1.000 rs604938 chr19:7903484 A/G cg26014689 chr19:7917955 EVI5L 0.45 6.32 0.36 1.08e-9 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10524888 chr4:39529563 UGDH 0.6 7.05 0.4 1.52e-11 Gut microbiome composition (summer); CESC cis rs9388451 0.839 rs10457469 chr6:126083658 G/A cg10911889 chr6:126070802 HEY2 0.4 5.4 0.31 1.47e-7 Brugada syndrome; CESC cis rs7520050 0.833 rs1085242 chr1:46544224 T/A cg03146154 chr1:46216737 IPP -0.43 -5.56 -0.32 6.54e-8 Red blood cell count;Reticulocyte count; CESC cis rs11809207 0.522 rs3762459 chr1:26494886 C/G cg00147160 chr1:26503991 CNKSR1 0.28 5.35 0.31 1.95e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07059151 chr22:24236617 MIF 0.59 6.22 0.36 1.92e-9 Gut microbiome composition (summer); CESC cis rs7560272 0.538 rs13006448 chr2:73924424 G/T cg20560298 chr2:73613845 ALMS1 0.45 6.1 0.35 3.71e-9 Schizophrenia; CESC cis rs344364 0.511 rs337284 chr16:1954799 A/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.51 -5.8 -0.34 1.93e-8 Glomerular filtration rate in chronic kidney disease; CESC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.12 -22.85 -0.81 1.38e-64 Prudent dietary pattern; CESC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg11494091 chr17:61959527 GH2 0.72 12.22 0.6 1.56e-27 Prudent dietary pattern; CESC cis rs9527 0.590 rs7901197 chr10:104840433 C/T cg04362960 chr10:104952993 NT5C2 0.44 5.63 0.33 4.71e-8 Arsenic metabolism; CESC cis rs9486715 0.867 rs4839828 chr6:96863326 G/A cg18709589 chr6:96969512 KIAA0776 0.44 6.27 0.36 1.49e-9 Headache; CESC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg18099408 chr3:52552593 STAB1 -0.33 -5.45 -0.32 1.17e-7 Bipolar disorder; CESC cis rs3087591 1.000 rs7406983 chr17:29703374 G/A cg24425628 chr17:29625626 OMG;NF1 -0.44 -5.39 -0.31 1.54e-7 Hip circumference; CESC cis rs9910055 0.529 rs408282 chr17:42182267 A/G cg19774624 chr17:42201019 HDAC5 0.58 7.65 0.43 3.73e-13 Total body bone mineral density; CESC cis rs2594989 0.943 rs2454501 chr3:11500089 A/G cg00170343 chr3:11313890 ATG7 0.56 5.1 0.3 6.55e-7 Circulating chemerin levels; CESC cis rs4132509 0.744 rs58594024 chr1:243862702 C/A cg21452805 chr1:244014465 NA 0.53 5.9 0.34 1.11e-8 RR interval (heart rate); CESC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg11764359 chr7:65958608 NA -0.5 -6.39 -0.37 7.63e-10 Calcium levels; CESC cis rs4819052 0.788 rs9978857 chr21:46705155 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.79 10.36 0.54 2.41e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1728785 0.818 rs1069289 chr16:68585317 C/A cg02972257 chr16:68554789 NA -0.62 -6.86 -0.39 4.94e-11 Ulcerative colitis; CESC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg18252515 chr7:66147081 NA -0.46 -6.05 -0.35 5e-9 Aortic root size; CESC cis rs6687430 0.532 rs12028449 chr1:10617034 A/G cg20482658 chr1:10539492 PEX14 -0.4 -7.9 -0.44 7.42e-14 Hand grip strength; CESC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3617 0.572 rs2256332 chr3:52855865 A/G cg11645453 chr3:52864694 ITIH4 -0.26 -5.1 -0.3 6.37e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg26335602 chr6:28129616 ZNF389 0.44 5.61 0.33 5.19e-8 Parkinson's disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11108432 chr8:10697698 PINX1 0.49 6.54 0.37 3.24e-10 Systemic lupus erythematosus; CESC trans rs7246657 0.882 rs28623164 chr19:37913453 G/A cg24637308 chr11:6592297 DNHD1 0.54 6.34 0.36 1.01e-9 Coronary artery calcification; CESC cis rs55788414 0.932 rs57461213 chr16:81185419 G/C cg06400318 chr16:81190750 PKD1L2 -0.6 -6.82 -0.39 6.19e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.663 rs3935296 chr1:46180470 T/C cg06784218 chr1:46089804 CCDC17 -0.43 -7.58 -0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg11366901 chr6:160182831 ACAT2 0.79 9.68 0.51 3.46e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs3091242 0.933 rs34933589 chr1:25788198 T/C cg12412775 chr1:25698385 RHCE 0.28 5.05 0.3 8.25e-7 Erythrocyte sedimentation rate; CESC cis rs7208859 0.623 rs12103508 chr17:29086781 T/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs55882075 0.936 rs34646062 chr5:179186318 A/G cg14593053 chr5:179126677 CANX -0.43 -5.73 -0.33 2.69e-8 Monocyte percentage of white cells; CESC cis rs7666738 0.791 rs1426674 chr4:98924247 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4481887 0.927 rs4390209 chr1:248472613 A/T cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs2797160 0.967 rs1343120 chr6:125992810 A/G cg05901451 chr6:126070800 HEY2 -0.45 -6.62 -0.38 1.93e-10 Endometrial cancer; CESC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.76 7.63 0.42 4.19e-13 Platelet count; CESC cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.78 -12.89 -0.62 7.79e-30 Personality dimensions; CESC cis rs4629710 0.592 rs13200165 chr6:131549167 G/C cg12606694 chr6:131520996 AKAP7 0.48 5.97 0.34 7.68e-9 Multiple myeloma (IgH translocation); CESC cis rs2816062 0.735 rs2816054 chr1:18896431 C/T cg18795169 chr1:18902165 NA -0.94 -19.04 -0.76 1.61e-51 Urate levels in lean individuals; CESC cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg12365402 chr11:9010492 NRIP3 -0.34 -5.49 -0.32 9.58e-8 Hemoglobin concentration; CESC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg24531977 chr5:56204891 C5orf35 -0.49 -6.06 -0.35 4.62e-9 Coronary artery disease; CESC cis rs734999 0.545 rs9970196 chr1:2574078 T/C cg18854424 chr1:2615690 NA -0.31 -5.88 -0.34 1.2e-8 Ulcerative colitis; CESC trans rs1728785 1.000 rs1728781 chr16:68567794 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.43 0.42 1.5e-12 Ulcerative colitis; CESC trans rs1973993 0.691 rs1989141 chr1:96898520 C/T cg10631902 chr5:14652156 NA 0.61 9.43 0.5 2.18e-18 Weight; CESC cis rs1788820 0.871 rs1623003 chr18:21165163 C/T cg14672496 chr18:21087552 C18orf8 0.48 6.33 0.36 1.05e-9 Body mass index; CESC cis rs9309473 0.950 rs10207264 chr2:73714097 G/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.69 -0.38 1.3e-10 Metabolite levels; CESC trans rs12681287 0.547 rs13267858 chr8:87510871 G/A cg27317242 chr8:23145699 R3HCC1 -0.53 -6.34 -0.36 9.67e-10 Caudate activity during reward; CESC trans rs1814175 0.645 rs28445479 chr11:50047999 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -18.51 -0.75 1.12e-49 Height; CESC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.32 -0.31 2.21e-7 Menopause (age at onset); CESC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg22535103 chr8:58192502 C8orf71 -0.79 -8.79 -0.48 1.94e-16 Developmental language disorder (linguistic errors); CESC cis rs6964587 1.000 rs17164275 chr7:91590408 A/G cg17063962 chr7:91808500 NA 0.57 7.74 0.43 2.03e-13 Breast cancer; CESC trans rs1728785 1.000 rs1069288 chr16:68585285 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.62 7.5 0.42 9.69e-13 Ulcerative colitis; CESC cis rs7044106 0.791 rs10739572 chr9:123489815 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.72 10.63 0.55 3.29e-22 Hip circumference adjusted for BMI; CESC trans rs11098499 0.908 rs2017057 chr4:120257711 A/G cg25214090 chr10:38739885 LOC399744 0.71 10.11 0.53 1.6e-20 Corneal astigmatism; CESC cis rs400736 0.740 rs225096 chr1:8105600 G/C cg25007680 chr1:8021821 PARK7 0.71 9.97 0.52 4.51e-20 Response to antidepressants and depression; CESC cis rs7264396 0.528 rs3787174 chr20:34487921 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.67 6.85 0.39 5.04e-11 Total cholesterol levels; CESC trans rs629535 0.514 rs55653755 chr8:70154383 A/C cg21567404 chr3:27674614 NA -0.83 -9.14 -0.49 1.69e-17 Dupuytren's disease; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg22217807 chr16:8768618 ABAT 0.48 6.28 0.36 1.35e-9 Weight; CESC cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg03467027 chr4:99064603 C4orf37 0.48 5.94 0.34 8.7e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg18402987 chr7:1209562 NA 0.63 7.37 0.41 2.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.52 0.46 1.24e-15 Colonoscopy-negative controls vs population controls; CESC cis rs3740540 0.530 rs2362505 chr10:126290739 T/G cg04949429 chr10:126290192 LHPP 0.4 5.6 0.33 5.23e-8 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs7520050 0.933 rs9787208 chr1:46314616 C/A cg03146154 chr1:46216737 IPP -0.48 -6.36 -0.36 8.91e-10 Red blood cell count;Reticulocyte count; CESC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg05255149 chr17:80675120 FN3KRP -0.46 -5.2 -0.3 3.94e-7 Breast cancer; CESC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg18402987 chr7:1209562 NA 0.76 7.55 0.42 7.26e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11792861 0.962 rs11789624 chr9:111796231 T/C cg13535736 chr9:111863775 C9orf5 -0.51 -6.76 -0.38 8.87e-11 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26692046 chr20:443277 TBC1D20 0.55 6.18 0.35 2.42e-9 Gut microbiome composition (summer); CESC cis rs72945132 0.882 rs59681006 chr11:70179401 T/C cg14191688 chr11:70257035 CTTN 0.43 5.38 0.31 1.62e-7 Coronary artery disease; CESC cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg25019033 chr10:957182 NA -0.64 -7.94 -0.44 5.61e-14 Eosinophil percentage of granulocytes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11612470 chr12:3068051 TEAD4 -0.44 -6.02 -0.35 5.91e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7089973 0.836 rs7895551 chr10:116625481 C/T cg23260525 chr10:116636907 FAM160B1 0.38 6.42 0.37 6.35e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg08859206 chr1:53392774 SCP2 0.54 7.15 0.4 8.22e-12 Monocyte count; CESC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg03605463 chr16:89740564 NA 0.63 7.64 0.42 4.07e-13 Vitiligo; CESC cis rs2404602 0.647 rs11633869 chr15:77133322 G/T cg23625390 chr15:77176239 SCAPER 0.47 6.64 0.38 1.75e-10 Blood metabolite levels; CESC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.69 -7.83 -0.43 1.18e-13 Gut microbiome composition (summer); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg19243777 chr12:26278767 BHLHE41 -0.48 -7.17 -0.4 7.4e-12 Vertical cup-disc ratio; CESC cis rs754466 0.914 rs12219971 chr10:79701526 T/C cg17075019 chr10:79541650 NA -0.68 -8.29 -0.45 5.91e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2929278 0.617 rs575082 chr15:44110142 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.47 -7.25 -0.41 4.44e-12 Schizophrenia; CESC cis rs10870270 0.500 rs9419217 chr10:133758379 A/G cg17892150 chr10:133769511 PPP2R2D -0.6 -8.56 -0.47 9.58e-16 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs763014 0.898 rs4984897 chr16:632180 G/C cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC cis rs7107174 1.000 rs10899454 chr11:77997513 T/C cg02023728 chr11:77925099 USP35 0.51 7.03 0.4 1.74e-11 Testicular germ cell tumor; CESC cis rs7216064 0.953 rs4790981 chr17:65921834 A/G cg07042672 chr17:66097459 LOC651250 -0.6 -7.33 -0.41 2.85e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10899021 1.000 rs7102084 chr11:74358132 T/C cg25880958 chr11:74394337 NA -0.72 -7.14 -0.4 8.93e-12 Response to metformin (IC50); CESC cis rs7818345 0.935 rs12542575 chr8:19286558 A/T cg11303988 chr8:19266685 CSGALNACT1 0.35 6.39 0.37 7.35e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg07507251 chr3:52567010 NT5DC2 0.41 7.28 0.41 3.83e-12 Bipolar disorder; CESC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 11.73 0.58 7.05e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg21782813 chr7:2030301 MAD1L1 0.38 5.26 0.31 2.99e-7 Bipolar disorder and schizophrenia; CESC cis rs1878931 0.535 rs55732163 chr16:3411518 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.67 -8.09 -0.44 2.17e-14 Body mass index (adult); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg13981078 chr14:105885112 MTA1 -0.38 -6.16 -0.35 2.64e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg11279151 chr3:101281821 RG9MTD1 0.46 6.15 0.35 2.9e-9 Colonoscopy-negative controls vs population controls; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg11692369 chr8:54755880 ATP6V1H 0.44 6.16 0.35 2.75e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg22920501 chr2:26401640 FAM59B -0.67 -8.12 -0.45 1.72e-14 Gut microbiome composition (summer); CESC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg18337363 chr3:52569053 NT5DC2 -0.3 -5.23 -0.31 3.47e-7 Bipolar disorder; CESC cis rs77140172 0.655 rs79387006 chr4:89672775 A/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.79 5.64 0.33 4.32e-8 Post bronchodilator FEV1; CESC trans rs72991 0.681 rs674803 chr11:121259993 G/C cg17871993 chr7:65673056 TPST1 -0.34 -6.12 -0.35 3.4e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs12079745 0.793 rs11809180 chr1:169100095 C/T cg09363564 chr1:169337483 NME7;BLZF1 -0.71 -5.68 -0.33 3.45e-8 QT interval; CESC cis rs6539267 0.741 rs2279759 chr12:106694988 T/C cg02476566 chr12:106696527 TCP11L2 0.6 7.1 0.4 1.15e-11 Tourette syndrome; CESC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg07308232 chr7:1071921 C7orf50 -0.45 -6.25 -0.36 1.65e-9 Longevity;Endometriosis; CESC cis rs703842 0.964 rs10431552 chr12:58178148 G/A cg00677455 chr12:58241039 CTDSP2 0.54 7.02 0.4 1.9e-11 Multiple sclerosis; CESC cis rs9549367 0.789 rs9604040 chr13:113910611 A/G cg00898013 chr13:113819073 PROZ 0.52 7.54 0.42 7.44e-13 Platelet distribution width; CESC cis rs4803468 1.000 rs4803465 chr19:41918158 A/G cg14132834 chr19:41945861 ATP5SL 0.59 7.51 0.42 9.11e-13 Height; CESC cis rs9309473 0.607 rs58962779 chr2:73555801 T/C cg20560298 chr2:73613845 ALMS1 -0.51 -7.05 -0.4 1.56e-11 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01042287 chr16:28884343 SH2B1 -0.54 -6.29 -0.36 1.27e-9 Gut microbiome composition (summer); CESC cis rs9549367 0.865 rs9549366 chr13:113907644 G/A cg18105134 chr13:113819100 PROZ -0.68 -8.71 -0.47 3.37e-16 Platelet distribution width; CESC cis rs1153858 1.000 rs2467858 chr15:45711492 A/G cg10760299 chr15:45669010 GATM 0.37 5.14 0.3 5.43e-7 Homoarginine levels; CESC cis rs11792861 0.926 rs76689835 chr9:111833792 G/A cg13535736 chr9:111863775 C9orf5 -0.52 -6.9 -0.39 3.71e-11 Menarche (age at onset); CESC cis rs2933343 0.729 rs789228 chr3:128601050 A/G cg24203234 chr3:128598194 ACAD9 0.43 5.78 0.33 2.04e-8 IgG glycosylation; CESC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg05368731 chr17:41323189 NBR1 0.77 10.72 0.55 1.69e-22 Menopause (age at onset); CESC cis rs6754311 0.731 rs892715 chr2:136576577 T/C cg07169764 chr2:136633963 MCM6 -0.66 -7.98 -0.44 4.39e-14 Mosquito bite size; CESC trans rs12659622 0.850 rs76376130 chr5:15678147 T/A cg22457238 chr19:58570995 ZNF135 -0.51 -6.03 -0.35 5.42e-9 Obesity-related traits; CESC trans rs11098499 0.663 rs9996501 chr4:120238918 C/A cg25214090 chr10:38739885 LOC399744 0.59 8.11 0.45 1.85e-14 Corneal astigmatism; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02114786 chr21:46293672 PTTG1IP -0.43 -6.16 -0.35 2.62e-9 Gambling; CESC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg18099408 chr3:52552593 STAB1 -0.3 -5.09 -0.3 6.8e-7 Bipolar disorder; CESC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg27170947 chr2:26402098 FAM59B 0.87 10.16 0.53 1.05e-20 Gut microbiome composition (summer); CESC cis rs9488822 0.651 rs3798228 chr6:116321156 T/C cg26893134 chr6:116381904 FRK 0.25 6.04 0.35 5.06e-9 Cholesterol, total;LDL cholesterol; CESC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg25985355 chr7:65971099 NA 0.33 5.38 0.31 1.63e-7 Aortic root size; CESC cis rs4803468 1.000 rs2241711 chr19:41911980 T/C cg14132834 chr19:41945861 ATP5SL -0.67 -8.31 -0.45 5.08e-15 Height; CESC cis rs9916302 0.861 rs752314 chr17:37410700 C/T cg20243544 chr17:37824526 PNMT 0.47 5.84 0.34 1.55e-8 Glomerular filtration rate (creatinine); CESC cis rs7605827 0.930 rs4140715 chr2:15515899 G/A cg19274914 chr2:15703543 NA 0.32 5.55 0.32 6.84e-8 Educational attainment (years of education); CESC cis rs9300255 0.544 rs1716175 chr12:123658388 A/T cg05973401 chr12:123451056 ABCB9 0.49 5.37 0.31 1.75e-7 Neutrophil percentage of white cells; CESC cis rs1153858 1.000 rs1153849 chr15:45695695 G/A cg21132104 chr15:45694354 SPATA5L1 0.78 10.4 0.54 1.79e-21 Homoarginine levels; CESC cis rs7824557 0.564 rs11782430 chr8:11226071 A/G cg21775007 chr8:11205619 TDH -0.47 -6.56 -0.37 2.78e-10 Retinal vascular caliber; CESC trans rs7395662 0.500 rs1304199 chr11:48699032 A/G cg00717180 chr2:96193071 NA -0.45 -6.1 -0.35 3.83e-9 HDL cholesterol; CESC cis rs684232 0.583 rs2543776 chr17:557149 G/A cg15660573 chr17:549704 VPS53 -0.74 -10.95 -0.56 2.87e-23 Prostate cancer; CESC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg06873352 chr17:61820015 STRADA 0.72 12.62 0.61 6.62e-29 Prudent dietary pattern; CESC trans rs60843830 1.000 rs17713396 chr2:227201 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 8.17 0.45 1.31e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs11711311 1.000 rs2305545 chr3:113499733 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.68 9.33 0.5 4.28e-18 IgG glycosylation; CESC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg10792982 chr14:105748885 BRF1 0.41 5.74 0.33 2.52e-8 Mean platelet volume;Platelet distribution width; CESC cis rs922182 0.547 rs6494458 chr15:64271095 A/C cg24729988 chr15:64271149 DAPK2 -0.59 -9.12 -0.49 1.94e-17 Blood protein levels; CESC cis rs2439831 0.681 rs28578454 chr15:43603032 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.82 8.05 0.44 2.73e-14 Lung cancer in ever smokers; CESC cis rs72945132 0.882 rs7116191 chr11:70159781 G/A cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs11190604 1.000 rs2495739 chr10:102335507 C/T cg07080220 chr10:102295463 HIF1AN 0.59 5.56 0.32 6.64e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs2860975 0.501 rs602941 chr10:96961184 G/A cg09036531 chr10:96991505 NA -0.64 -10.17 -0.53 9.72e-21 Immune response to smallpox vaccine (IL-6); CESC cis rs9399137 0.507 rs11754021 chr6:135308375 A/G cg22676075 chr6:135203613 NA 0.54 7.06 0.4 1.46e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs9916302 0.653 rs11657058 chr17:37699378 T/G cg20243544 chr17:37824526 PNMT 0.53 5.26 0.31 3.03e-7 Glomerular filtration rate (creatinine); CESC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg23172400 chr8:95962367 TP53INP1 -0.43 -8.81 -0.48 1.65e-16 Type 2 diabetes; CESC cis rs644799 0.965 rs1944080 chr11:95503636 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.72 9.66 0.51 4.04e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg11663144 chr21:46675770 NA -0.61 -9.31 -0.5 5.26e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1008375 0.866 rs12233712 chr4:17570063 T/A cg16339924 chr4:17578868 LAP3 0.63 7.93 0.44 6.15e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs17253792 0.822 rs17253716 chr14:56153661 G/C cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs11718455 0.921 rs35872933 chr3:44028515 T/G cg08738300 chr3:44038990 NA 0.48 6.47 0.37 4.83e-10 Coronary artery disease; CESC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg15145296 chr3:125709740 NA -0.51 -5.35 -0.31 1.92e-7 Blood pressure (smoking interaction); CESC cis rs2380220 0.720 rs9400397 chr6:95980623 C/A cg23517279 chr6:96025343 MANEA 0.53 5.63 0.33 4.68e-8 Behavioural disinhibition (generation interaction); CESC cis rs6061231 0.544 rs2427314 chr20:60973666 C/T cg15674680 chr20:60982522 CABLES2 0.54 6.72 0.38 1.08e-10 Colorectal cancer; CESC trans rs9951602 0.541 rs12454297 chr18:76654445 A/G cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs2439831 0.717 rs28495368 chr15:43895642 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.69 8.54 0.46 1.03e-15 Lung cancer in ever smokers; CESC cis rs9457247 0.935 rs2757046 chr6:167374353 C/T cg07741184 chr6:167504864 NA -0.3 -5.44 -0.32 1.19e-7 Crohn's disease; CESC cis rs12142240 0.698 rs68112720 chr1:46813888 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs4865169 0.691 rs1056364 chr4:57889677 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.38 -5.23 -0.31 3.42e-7 Breast cancer; CESC cis rs35110281 0.807 rs1598206 chr21:45058776 A/G cg04455712 chr21:45112962 RRP1B 0.42 6.24 0.36 1.75e-9 Mean corpuscular volume; CESC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg19717773 chr7:2847554 GNA12 -0.54 -7.62 -0.42 4.43e-13 Height; CESC trans rs7980799 0.591 rs10844614 chr12:33605702 A/C cg26384229 chr12:38710491 ALG10B -0.57 -8.24 -0.45 8.04e-15 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs7680126 0.633 rs4698040 chr4:10352550 C/T cg11266682 chr4:10021025 SLC2A9 -0.42 -5.44 -0.32 1.21e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs11650494 0.516 rs9907942 chr17:47513891 C/T cg08112188 chr17:47440006 ZNF652 0.78 5.16 0.3 4.88e-7 Prostate cancer; CESC cis rs9837602 0.688 rs793492 chr3:99499736 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.45 -5.74 -0.33 2.58e-8 Breast cancer; CESC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg00908189 chr16:619842 PIGQ 0.64 8.94 0.48 6.68e-17 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16321116 chr14:59655311 DAAM1 0.68 7.6 0.42 5.21e-13 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22669566 chr12:679287 NINJ2 0.65 7.17 0.4 7.41e-12 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg00166722 chr3:10149974 C3orf24 0.49 5.98 0.34 7.37e-9 Alzheimer's disease; CESC cis rs36051895 0.603 rs11795305 chr9:5179920 G/C cg02405213 chr9:5042618 JAK2 -0.46 -5.32 -0.31 2.24e-7 Pediatric autoimmune diseases; CESC cis rs2066819 1.000 rs11171806 chr12:56733531 A/G cg26714650 chr12:56694279 CS 1.3 8.93 0.48 7.55e-17 Psoriasis vulgaris; CESC cis rs637571 0.522 rs649000 chr11:65742933 T/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.74 10.58 0.54 4.74e-22 Eosinophil percentage of white cells; CESC cis rs3741151 0.773 rs73546720 chr11:73252409 C/T cg17517138 chr11:73019481 ARHGEF17 1.05 7.72 0.43 2.46e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.74 -9.68 -0.51 3.62e-19 Mean platelet volume; CESC cis rs3820928 1.000 rs11686072 chr2:227777493 A/T cg05526886 chr2:227700861 RHBDD1 -0.44 -5.75 -0.33 2.45e-8 Pulmonary function; CESC cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg19468946 chr17:37922297 IKZF3 -0.4 -5.22 -0.31 3.56e-7 Glomerular filtration rate (creatinine); CESC cis rs12142240 0.698 rs17413701 chr1:46818452 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs9457247 0.765 rs9459838 chr6:167426599 C/G cg23791538 chr6:167370224 RNASET2 -0.54 -7.39 -0.41 1.98e-12 Crohn's disease; CESC cis rs3106136 0.546 rs7685121 chr4:95175682 G/A cg11021082 chr4:95130006 SMARCAD1 -0.67 -11.02 -0.56 1.7e-23 Capecitabine sensitivity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07898084 chr13:53029385 CKAP2 0.48 6.29 0.36 1.33e-9 Gut microbiota (bacterial taxa); CESC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.15 0.4 8.41e-12 Height; CESC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg02034447 chr16:89574710 SPG7 0.42 5.38 0.31 1.65e-7 Multiple myeloma (IgH translocation); CESC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg11766577 chr21:47581405 C21orf56 -0.46 -6.36 -0.36 8.76e-10 Testicular germ cell tumor; CESC cis rs72901758 0.810 rs61740716 chr17:76244648 G/A cg23302638 chr17:76210176 BIRC5 0.49 5.38 0.31 1.63e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs72781680 0.904 rs72796340 chr2:24143622 T/A cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs3796352 1.000 rs113995589 chr3:53132372 A/T cg12962167 chr3:53033115 SFMBT1 0.54 5.13 0.3 5.5e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg19717773 chr7:2847554 GNA12 -0.47 -6.56 -0.37 2.73e-10 Height; CESC cis rs7937682 0.883 rs490492 chr11:111465150 C/T cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC trans rs877282 0.533 rs10904565 chr10:819991 G/T cg22713356 chr15:30763199 NA 1.07 9.68 0.51 3.6e-19 Uric acid levels; CESC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg15445000 chr17:37608096 MED1 0.41 6.83 0.39 5.8200000000000003e-11 Glomerular filtration rate (creatinine); CESC cis rs6912958 0.781 rs9450739 chr6:88268271 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.58 -0.37 2.55e-10 Monocyte percentage of white cells; CESC cis rs10744422 1.000 rs897385 chr12:123341297 A/G cg22842854 chr12:123319900 HIP1R -0.67 -5.28 -0.31 2.69e-7 Schizophrenia; CESC cis rs7927771 0.524 rs3758655 chr11:47703943 T/C cg18512352 chr11:47633146 NA 0.35 5.39 0.31 1.53e-7 Subjective well-being; CESC cis rs7580658 0.929 rs11886231 chr2:128028130 G/A cg10021288 chr2:128175891 PROC -0.41 -6.45 -0.37 5.16e-10 Protein C levels; CESC cis rs7786877 0.582 rs2075674 chr7:100225031 G/A cg27028030 chr7:100209634 MOSPD3 0.58 5.49 0.32 9.24e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4629710 0.617 rs28360555 chr6:131538952 C/A cg12606694 chr6:131520996 AKAP7 0.45 5.55 0.32 6.8e-8 Multiple myeloma (IgH translocation); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03111502 chr11:124609885 NRGN 0.47 6.0 0.35 6.57e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.88 0.56 4.81e-23 Prudent dietary pattern; CESC cis rs2204008 0.640 rs2320744 chr12:38162389 A/G cg26384229 chr12:38710491 ALG10B 0.75 10.86 0.55 5.81e-23 Bladder cancer; CESC cis rs9916302 0.904 rs8068427 chr17:37511517 G/A cg00129232 chr17:37814104 STARD3 0.52 6.49 0.37 4.13e-10 Glomerular filtration rate (creatinine); CESC cis rs6964587 0.934 rs7811328 chr7:91720931 A/T cg17063962 chr7:91808500 NA 0.55 7.59 0.42 5.51e-13 Breast cancer; CESC cis rs936229 0.798 rs1869959 chr15:75147332 A/C cg14664628 chr15:75095509 CSK -0.76 -10.48 -0.54 1.04e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg17971929 chr21:40555470 PSMG1 1.03 14.25 0.66 1.39e-34 Cognitive function; CESC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg03352830 chr11:487213 PTDSS2 0.74 7.2 0.4 6.15e-12 Body mass index; CESC cis rs829661 0.512 rs11676852 chr2:30792898 A/C cg12454169 chr2:30669597 LCLAT1 -0.44 -5.47 -0.32 1.04e-7 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs7814319 1.000 rs6468495 chr8:97259953 C/A cg20787634 chr8:97240163 UQCRB -0.52 -6.78 -0.38 7.88e-11 Lung function (FVC); CESC cis rs4253772 0.550 rs715515 chr22:46720921 G/A cg00784671 chr22:46762841 CELSR1 -0.56 -5.71 -0.33 3.09e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7809950 1.000 rs3801948 chr7:107238447 A/T cg23024343 chr7:107201750 COG5 -0.41 -5.77 -0.33 2.19e-8 Coronary artery disease; CESC cis rs9649465 1.000 rs4588795 chr7:123349924 A/G cg04330084 chr7:123175371 IQUB 0.38 5.13 0.3 5.56e-7 Migraine; CESC cis rs672059 1.000 rs559476 chr1:183160704 T/C ch.1.3577855R chr1:183094577 LAMC1 0.54 7.01 0.4 1.93e-11 Hypertriglyceridemia; CESC cis rs599083 0.530 rs686921 chr11:68170833 G/T cg16797656 chr11:68205561 LRP5 -0.38 -5.06 -0.3 7.91e-7 Bone mineral density (spine); CESC cis rs9291683 0.588 rs12507330 chr4:10002195 G/A cg00071950 chr4:10020882 SLC2A9 0.8 14.44 0.66 2.93e-35 Bone mineral density; CESC cis rs1564271 0.528 rs2489589 chr10:26983095 A/G cg13837822 chr10:26931731 LOC731789 0.42 6.46 0.37 4.93e-10 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CESC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg23758822 chr17:41437982 NA 1.05 16.25 0.71 1.17e-41 Menopause (age at onset); CESC cis rs1008375 1.000 rs10939748 chr4:17691230 T/C cg02297831 chr4:17616191 MED28 0.5 5.88 0.34 1.24e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs5758659 1.000 rs134882 chr22:42670965 A/G cg05082376 chr22:42548792 NA -0.39 -5.9 -0.34 1.09e-8 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07148452 chr15:90176987 KIF7 -0.68 -7.48 -0.42 1.09e-12 Gut microbiome composition (summer); CESC cis rs35362007 0.530 rs17835086 chr14:96012465 A/G cg13511115 chr14:96000878 GLRX5;SNHG10;SCARNA13 0.66 5.36 0.31 1.81e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs2816062 0.721 rs2816047 chr1:18893728 A/C cg18795169 chr1:18902165 NA -0.95 -19.06 -0.76 1.32e-51 Urate levels in lean individuals; CESC cis rs2439831 0.867 rs76542740 chr15:43891512 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.7 8.6 0.47 6.89e-16 Lung cancer in ever smokers; CESC cis rs933688 0.938 rs6866923 chr5:90669352 A/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.15 15.15 0.68 8.88e-38 Smoking behavior; CESC cis rs4906332 0.966 rs35799018 chr14:103893475 G/A cg09975044 chr14:104007538 NA 0.46 6.38 0.36 7.81e-10 Coronary artery disease; CESC cis rs4237845 0.715 rs4760340 chr12:58275176 A/T cg00677455 chr12:58241039 CTDSP2 0.55 7.2 0.4 6.21e-12 Intelligence (multi-trait analysis); CESC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7918232 0.941 rs1755399 chr10:27394958 A/G cg14442939 chr10:27389572 ANKRD26 0.68 6.47 0.37 4.78e-10 Breast cancer; CESC trans rs7582180 0.700 rs1437971 chr2:100986964 A/C cg02956372 chr4:967467 DGKQ 0.62 6.09 0.35 3.93e-9 Intelligence (multi-trait analysis); CESC cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg23248424 chr5:179741104 GFPT2 -0.68 -9.2 -0.49 1.11e-17 Height; CESC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.76 0.33 2.27e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6828523 0.698 rs73869046 chr4:175854498 C/T cg14561282 chr4:175839468 ADAM29 0.44 5.15 0.3 5.09e-7 Breast cancer; CESC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg22823121 chr1:150693482 HORMAD1 0.45 6.26 0.36 1.52e-9 Melanoma; CESC cis rs2294693 0.945 rs2073015 chr6:41008747 A/G cg14418226 chr6:40996092 UNC5CL 0.51 5.89 0.34 1.18e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg11905131 chr22:24372483 LOC391322 -0.71 -10.17 -0.53 9.93e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg20476274 chr7:133979776 SLC35B4 0.66 9.47 0.5 1.6e-18 Mean platelet volume; CESC trans rs637571 0.615 rs10160792 chr11:65667149 C/G cg17712092 chr4:129076599 LARP1B 0.85 11.64 0.58 1.48e-25 Eosinophil percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25810379 chr11:64578055 MEN1 -0.44 -6.31 -0.36 1.16e-9 Gambling; CESC cis rs4927850 0.709 rs6783079 chr3:195652708 T/C cg01181863 chr3:195395398 SDHAP2 -0.69 -7.75 -0.43 1.94e-13 Pancreatic cancer; CESC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg11764359 chr7:65958608 NA -0.78 -11.2 -0.57 4.25e-24 Aortic root size; CESC cis rs7044106 0.791 rs4836831 chr9:123496570 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.75 10.99 0.56 2.18e-23 Hip circumference adjusted for BMI; CESC cis rs6570726 0.967 rs9497316 chr6:145792387 G/T cg23711669 chr6:146136114 FBXO30 -0.69 -10.03 -0.52 2.86e-20 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11027325 chr2:239148674 HES6 0.56 6.08 0.35 4.19e-9 Gut microbiome composition (summer); CESC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg18099408 chr3:52552593 STAB1 -0.33 -5.41 -0.32 1.44e-7 Bipolar disorder; CESC trans rs561341 0.882 rs28649357 chr17:30367190 A/G cg20587970 chr11:113659929 NA -1.02 -12.66 -0.61 4.61e-29 Hip circumference adjusted for BMI; CESC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg17178900 chr1:205818956 PM20D1 -0.41 -5.66 -0.33 3.86e-8 Parkinson's disease; CESC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.39 -0.37 7.41e-10 Depression; CESC cis rs12530845 0.943 rs3800762 chr7:135347601 T/A cg23117316 chr7:135346802 PL-5283 -0.45 -5.54 -0.32 7.36e-8 Red blood cell traits; CESC cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg05347473 chr6:146136440 FBXO30 -0.61 -7.24 -0.41 4.91e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs258892 0.947 rs266446 chr5:72182030 T/G cg21869765 chr5:72125136 TNPO1 0.45 5.6 0.33 5.35e-8 Small cell lung carcinoma; CESC cis rs67311347 1.000 rs1466236 chr3:40462162 C/T cg01475735 chr3:40494733 NA -0.4 -5.11 -0.3 6.1e-7 Renal cell carcinoma; CESC cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg15605315 chr1:45957053 TESK2 0.43 5.48 0.32 9.9e-8 High light scatter reticulocyte count; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg20139898 chr1:26437522 PDIK1L -0.43 -6.15 -0.35 2.82e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6933660 0.800 rs2046371 chr6:151754744 G/A cg02564969 chr6:151773285 C6orf211;RMND1 0.6 8.04 0.44 3.09e-14 Menarche (age at onset); CESC cis rs7432375 0.610 rs6793936 chr3:136509793 A/C cg15507776 chr3:136538369 TMEM22 0.6 7.86 0.43 9.73e-14 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs11122272 0.735 rs2437150 chr1:231488524 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.53 7.51 0.42 9.13e-13 Hemoglobin concentration; CESC cis rs17253792 0.822 rs8013831 chr14:56172898 G/A cg01858014 chr14:56050164 KTN1 -0.62 -5.67 -0.33 3.78e-8 Putamen volume; CESC cis rs1879734 0.731 rs12086451 chr1:54157640 C/T cg23596471 chr1:54105337 GLIS1 0.34 5.41 0.32 1.42e-7 Mitral valve prolapse; CESC cis rs9840812 0.535 rs695983 chr3:136064547 C/T cg15507776 chr3:136538369 TMEM22 0.47 5.9 0.34 1.11e-8 Fibrinogen levels; CESC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg18350739 chr11:68623251 NA -0.47 -6.86 -0.39 4.93e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1008375 0.932 rs4698628 chr4:17608620 A/G cg16339924 chr4:17578868 LAP3 0.64 8.22 0.45 9.39e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7662987 0.517 rs2602882 chr4:100040765 C/T cg12011299 chr4:100065546 ADH4 0.6 6.57 0.37 2.59e-10 Smoking initiation; CESC cis rs7607369 0.648 rs7559629 chr2:219657013 A/T cg02176678 chr2:219576539 TTLL4 -0.48 -8.21 -0.45 9.44e-15 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs6963495 0.818 rs711430 chr7:105167969 A/G cg02135003 chr7:105160482 PUS7 -0.43 -5.98 -0.34 7.27e-9 Bipolar disorder (body mass index interaction); CESC cis rs7100689 0.577 rs2185427 chr10:82056667 G/T cg00277334 chr10:82204260 NA 0.53 7.0 0.4 2.05e-11 Post bronchodilator FEV1; CESC cis rs9914988 0.887 rs28873200 chr17:27149512 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs6500602 0.702 rs2058812 chr16:4524443 C/G cg08645402 chr16:4508243 NA 0.53 8.44 0.46 2.06e-15 Schizophrenia; CESC cis rs2404602 0.647 rs11072620 chr15:77048770 T/A cg23625390 chr15:77176239 SCAPER -0.47 -6.54 -0.37 3.2e-10 Blood metabolite levels; CESC cis rs4803468 1.000 rs55986560 chr19:41939835 C/T cg09537434 chr19:41945824 ATP5SL 1.06 19.91 0.77 1.51e-54 Height; CESC cis rs950776 0.720 rs11633223 chr15:78935476 T/C cg06917634 chr15:78832804 PSMA4 0.56 6.66 0.38 1.53e-10 Sudden cardiac arrest; CESC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg16680214 chr1:154839983 KCNN3 -0.45 -6.94 -0.39 2.95e-11 Prostate cancer; CESC cis rs9902453 0.904 rs12939344 chr17:28328819 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -9.44 -0.5 1.96e-18 Coffee consumption (cups per day); CESC cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.55 -0.42 6.87e-13 Alzheimer's disease; CESC cis rs7582720 0.887 rs72934591 chr2:204019762 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 7.04 0.4 1.7e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs116095464 0.510 rs7723883 chr5:270798 T/C cg00938859 chr5:1591904 SDHAP3 0.64 6.95 0.39 2.77e-11 Breast cancer; CESC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg24675658 chr1:53192096 ZYG11B 0.57 7.64 0.42 4.08e-13 Monocyte count; CESC trans rs698833 0.669 rs1584885 chr2:44647038 A/C cg18595293 chr21:44527201 U2AF1 -0.44 -6.01 -0.35 6.03e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs10744422 1.000 rs4993320 chr12:123338092 T/C cg25930673 chr12:123319894 HIP1R -0.76 -5.88 -0.34 1.26e-8 Schizophrenia; CESC cis rs72781680 0.950 rs56128748 chr2:24126809 T/G cg08917208 chr2:24149416 ATAD2B 0.88 7.96 0.44 5.07e-14 Lymphocyte counts; CESC cis rs4237845 0.537 rs11172367 chr12:58272486 T/G cg00677455 chr12:58241039 CTDSP2 0.78 10.4 0.54 1.76e-21 Intelligence (multi-trait analysis); CESC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 12.99 0.62 3.48e-30 Platelet count; CESC cis rs11625487 0.609 rs78371022 chr14:77971029 G/A cg20045696 chr14:77926864 AHSA1 -0.71 -5.29 -0.31 2.52e-7 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs17253792 0.822 rs74609892 chr14:56053002 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.63 0.33 4.57e-8 Putamen volume; CESC cis rs734999 0.505 rs4278312 chr1:2539555 A/G cg18854424 chr1:2615690 NA 0.29 5.87 0.34 1.29e-8 Ulcerative colitis; CESC trans rs7615952 1.000 rs9289275 chr3:125648659 A/T cg07211511 chr3:129823064 LOC729375 -1.11 -14.85 -0.67 1.03e-36 Blood pressure (smoking interaction); CESC cis rs6084875 1.000 rs6084875 chr20:4742705 A/G cg05143360 chr20:4741328 NA -0.41 -5.41 -0.32 1.42e-7 Systemic lupus erythematosus; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg08377800 chr16:31885014 ZNF267 -0.54 -7.4 -0.41 1.8e-12 Asthma; CESC cis rs12597458 0.789 rs7186207 chr16:72035359 C/T cg16558253 chr16:72132732 DHX38 -0.4 -5.81 -0.34 1.81e-8 Prostate cancer; CESC cis rs7246657 0.943 rs10417844 chr19:37837587 C/T cg23950597 chr19:37808831 NA -0.55 -6.09 -0.35 3.96e-9 Coronary artery calcification; CESC cis rs7662987 0.517 rs1453873 chr4:100022571 T/C cg12011299 chr4:100065546 ADH4 0.6 6.6 0.38 2.23e-10 Smoking initiation; CESC cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs9300255 0.539 rs1969355 chr12:123742061 G/A cg05973401 chr12:123451056 ABCB9 0.44 5.32 0.31 2.23e-7 Neutrophil percentage of white cells; CESC cis rs12579753 0.692 rs9943807 chr12:82279404 T/A cg21193143 chr12:82153300 PPFIA2 -0.36 -5.44 -0.32 1.18e-7 Resting heart rate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20940661 chr2:18060086 KCNS3 -0.4 -6.47 -0.37 4.76e-10 Gambling; CESC cis rs7904368 0.806 rs1130684 chr10:16859335 C/G cg14835575 chr10:16859367 RSU1 0.65 7.46 0.42 1.21e-12 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg22029157 chr1:209979665 IRF6 0.7 7.88 0.44 8.64e-14 Cleft lip with or without cleft palate; CESC cis rs9361491 0.510 rs1507151 chr6:79483246 T/C cg05283184 chr6:79620031 NA -0.36 -5.03 -0.3 9e-7 Intelligence (multi-trait analysis); CESC cis rs55728055 0.661 rs7285893 chr22:32010042 A/G cg01338084 chr22:32026380 PISD 1.06 7.47 0.42 1.16e-12 Age-related hearing impairment; CESC cis rs6460942 0.597 rs35317839 chr7:12524397 C/A cg02935154 chr7:12443704 VWDE -0.55 -5.53 -0.32 7.71e-8 Coronary artery disease; CESC cis rs11785400 0.793 rs11785376 chr8:143730412 C/T cg10596483 chr8:143751796 JRK 0.42 5.33 0.31 2.06e-7 Schizophrenia; CESC cis rs10789491 1.000 rs4553120 chr1:47165729 C/T cg15501359 chr1:47185051 KIAA0494 0.79 8.81 0.48 1.66e-16 Response to hepatitis C treatment; CESC cis rs4808199 0.895 rs10403731 chr19:19469296 G/A cg03709012 chr19:19516395 GATAD2A 1.08 12.14 0.6 2.97e-27 Nonalcoholic fatty liver disease; CESC cis rs6701037 0.681 rs1894709 chr1:175132371 G/T cg00321850 chr1:175162397 KIAA0040 -0.41 -5.87 -0.34 1.29e-8 Alcohol dependence; CESC cis rs12701220 0.689 rs6973645 chr7:1112246 C/T cg26769984 chr7:1090371 C7orf50 0.56 5.68 0.33 3.52e-8 Bronchopulmonary dysplasia; CESC cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg05585544 chr11:47624801 NA -0.48 -7.04 -0.4 1.67e-11 Subjective well-being; CESC cis rs4803468 1.000 rs2241709 chr19:41912250 C/T cg09537434 chr19:41945824 ATP5SL -1.03 -18.3 -0.75 6.27e-49 Height; CESC cis rs72781680 0.752 rs55801864 chr2:23922325 C/T cg20701182 chr2:24300061 SF3B14 0.78 6.78 0.38 7.89e-11 Lymphocyte counts; CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg22907277 chr7:1156413 C7orf50 0.46 6.56 0.37 2.79e-10 Longevity;Endometriosis; CESC cis rs8114671 0.562 rs4911164 chr20:33479488 G/C cg07148914 chr20:33460835 GGT7 0.53 7.02 0.4 1.91e-11 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09704553 chr12:27167052 TM7SF3 0.59 6.71 0.38 1.18e-10 Gut microbiome composition (summer); CESC cis rs4555082 0.830 rs3803319 chr14:105752458 G/A cg06808227 chr14:105710500 BRF1 -0.55 -6.15 -0.35 2.82e-9 Mean platelet volume;Platelet distribution width; CESC cis rs9811920 0.609 rs7638900 chr3:99670773 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.57 -6.98 -0.39 2.42e-11 Axial length; CESC cis rs2380220 0.808 rs2263180 chr6:95902309 G/A cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs796364 0.806 rs6743396 chr2:200860138 T/C cg23649088 chr2:200775458 C2orf69 0.6 5.37 0.31 1.74e-7 Schizophrenia; CESC cis rs796364 0.951 rs1105964 chr2:201000776 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -6.83 -0.39 5.64e-11 Schizophrenia; CESC cis rs10743315 0.557 rs80051304 chr12:19286086 G/A cg02471346 chr12:19282374 PLEKHA5 0.71 5.34 0.31 1.96e-7 Gut microbiota (bacterial taxa); CESC cis rs12155623 0.803 rs6987879 chr8:49808062 T/C cg22283653 chr8:49824208 NA -0.38 -5.35 -0.31 1.9e-7 Sudden cardiac arrest; CESC cis rs12541635 0.739 rs10955412 chr8:107075592 T/C cg10147462 chr8:107024639 NA -0.37 -5.2 -0.3 4.05e-7 Age of smoking initiation; CESC trans rs11148252 0.532 rs9526975 chr13:53255804 C/T cg18335740 chr13:41363409 SLC25A15 0.52 6.85 0.39 5.13e-11 Lewy body disease; CESC cis rs7143963 0.666 rs66970053 chr14:103307655 G/C cg24154132 chr14:103367632 TRAF3 0.36 6.59 0.38 2.34e-10 Body mass index; CESC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.61 5.2 0.3 4.03e-7 Depression; CESC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg19622623 chr12:86230825 RASSF9 -0.47 -5.96 -0.34 7.92e-9 Major depressive disorder; CESC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.82 7.59 0.42 5.46e-13 Breast cancer; CESC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg20999797 chr1:1681921 NA 0.27 5.2 0.3 4.06e-7 Body mass index; CESC cis rs6089584 1.000 rs3787425 chr20:60559256 C/T cg13770153 chr20:60521292 NA -0.45 -5.9 -0.34 1.12e-8 Body mass index; CESC cis rs9911578 1.000 rs172565 chr17:56808996 A/T cg05425664 chr17:57184151 TRIM37 -0.51 -7.16 -0.4 7.78e-12 Intelligence (multi-trait analysis); CESC cis rs10129255 0.957 rs12590735 chr14:107187899 A/G cg23076370 chr14:107095027 NA -0.44 -5.4 -0.31 1.48e-7 Kawasaki disease; CESC cis rs12477438 0.700 rs10190421 chr2:99670711 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs6964587 0.967 rs34040612 chr7:91798916 G/T cg17063962 chr7:91808500 NA 0.55 7.46 0.42 1.25e-12 Breast cancer; CESC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg17747265 chr1:1875780 NA -0.57 -9.25 -0.49 7.79e-18 Body mass index; CESC cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs34779708 0.966 rs17499247 chr10:35426755 A/G cg04310649 chr10:35416472 CREM -0.52 -6.45 -0.37 5.15e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25922032 chr5:112043407 APC 0.54 6.19 0.36 2.32e-9 Gut microbiome composition (summer); CESC cis rs561341 0.505 rs548298 chr17:30297494 C/A cg19193384 chr17:30244184 NA -0.61 -6.41 -0.37 6.51e-10 Hip circumference adjusted for BMI; CESC cis rs950169 0.922 rs12910334 chr15:84958318 G/A cg17507749 chr15:85114479 UBE2QP1 0.6 6.59 0.38 2.42e-10 Schizophrenia; CESC cis rs10788972 0.844 rs6588502 chr1:54563156 A/G cg25741118 chr1:54482237 LDLRAD1 -0.24 -5.67 -0.33 3.72e-8 Parkinson disease and lewy body pathology; CESC cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg24296786 chr1:45957014 TESK2 0.63 8.16 0.45 1.37e-14 High light scatter reticulocyte count; CESC cis rs763014 0.898 rs4984897 chr16:632180 G/C cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC cis rs3733585 0.699 rs6815001 chr4:9958662 G/C cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9596863 1.000 rs9568946 chr13:54430220 T/C ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs9916302 0.707 rs11078903 chr17:37631924 G/A cg07936489 chr17:37558343 FBXL20 -0.8 -11.68 -0.58 1.06e-25 Glomerular filtration rate (creatinine); CESC cis rs79349575 0.783 rs9747646 chr17:47016882 C/T cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg11766577 chr21:47581405 C21orf56 -0.47 -6.32 -0.36 1.13e-9 Testicular germ cell tumor; CESC cis rs6460942 0.915 rs2216051 chr7:12304054 G/A cg06484146 chr7:12443880 VWDE -0.4 -5.63 -0.33 4.48e-8 Coronary artery disease; CESC cis rs881375 0.678 rs10760130 chr9:123701990 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 6.36 0.36 8.95e-10 Rheumatoid arthritis; CESC cis rs6570726 0.905 rs396492 chr6:145816180 C/G cg05347473 chr6:146136440 FBXO30 0.49 6.66 0.38 1.53e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs193541 0.632 rs6878609 chr5:122095549 C/G cg19412675 chr5:122181750 SNX24 0.44 5.06 0.3 7.91e-7 Glucose homeostasis traits; CESC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg00166722 chr3:10149974 C3orf24 0.44 5.7 0.33 3.27e-8 Alzheimer's disease; CESC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.05e-8 Lung cancer; CESC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.94 -11.51 -0.58 4.07e-25 Gut microbiome composition (summer); CESC trans rs1977584 0.725 rs61853973 chr10:45388595 T/C cg09262100 chr14:103416268 CDC42BPB 0.62 6.21 0.36 2.02e-9 Selective IgA deficiency; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg02920897 chr13:50699344 DLEU2 0.47 6.19 0.36 2.25e-9 Thyroid stimulating hormone; CESC cis rs2749592 0.918 rs1208653 chr10:38253826 C/G cg00409905 chr10:38381863 ZNF37A 0.43 5.46 0.32 1.11e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7605827 0.930 rs3796002 chr2:15567649 T/C cg19274914 chr2:15703543 NA 0.36 6.6 0.38 2.24e-10 Educational attainment (years of education); CESC cis rs7927771 0.524 rs10742817 chr11:47689343 A/G cg18512352 chr11:47633146 NA -0.34 -5.3 -0.31 2.4e-7 Subjective well-being; CESC cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg04455712 chr21:45112962 RRP1B 0.37 5.36 0.31 1.82e-7 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09872009 chr21:10990119 TPTE -0.52 -6.43 -0.37 6e-10 Gut microbiome composition (summer); CESC cis rs546131 0.928 rs547504 chr11:34847225 G/T cg11058730 chr11:34937778 PDHX;APIP 0.44 5.5 0.32 8.87e-8 Lung disease severity in cystic fibrosis; CESC cis rs208520 0.690 rs12202401 chr6:66760544 A/G cg07460842 chr6:66804631 NA 0.96 12.67 0.61 4.52e-29 Exhaled nitric oxide output; CESC cis rs2974760 0.606 rs2858918 chr16:201183 T/C cg08400316 chr16:204221 HBZ 0.61 10.14 0.53 1.26e-20 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs9549260 0.753 rs10507486 chr13:41186501 A/G cg21288729 chr13:41239152 FOXO1 -0.51 -5.32 -0.31 2.26e-7 Red blood cell count; CESC cis rs7777484 0.534 rs2533888 chr7:2831083 T/C cg18446336 chr7:2847575 GNA12 -0.41 -6.84 -0.39 5.44e-11 Height; CESC cis rs7927592 0.913 rs7106010 chr11:68365212 C/T cg20283391 chr11:68216788 NA -0.62 -7.48 -0.42 1.09e-12 Total body bone mineral density; CESC cis rs4076764 0.958 rs11590567 chr1:163396438 A/G cg06092702 chr1:163392909 NA -0.42 -6.06 -0.35 4.74e-9 Motion sickness; CESC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.89 0.52 7.86e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7208859 0.623 rs77544470 chr17:28934550 C/A cg13385521 chr17:29058706 SUZ12P 0.78 5.67 0.33 3.78e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4594175 0.926 rs113095693 chr14:51600511 G/C cg23942311 chr14:51606299 NA 0.4 5.94 0.34 9.07e-9 Cancer; CESC cis rs919433 1.000 rs6761919 chr2:198163328 A/G cg03934865 chr2:198174659 NA -0.46 -6.99 -0.39 2.23e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7666738 0.519 rs13136069 chr4:98819568 C/T cg05340658 chr4:99064831 C4orf37 0.54 6.4 0.37 6.9e-10 Colonoscopy-negative controls vs population controls; CESC trans rs1814175 0.869 rs10769600 chr11:49681832 C/T cg03929089 chr4:120376271 NA -0.87 -13.36 -0.63 1.83e-31 Height; CESC cis rs7084402 0.967 rs1649018 chr10:60288150 T/G cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs1348850 0.567 rs7605493 chr2:178534983 C/G cg22681709 chr2:178499509 PDE11A -0.49 -7.27 -0.41 4.12e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14835113 chr13:111303423 CARS2 0.62 8.71 0.47 3.41e-16 Fibrinogen levels; CESC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.46 -0.5 1.7e-18 Alzheimer's disease; CESC cis rs9354308 0.903 rs1938064 chr6:66559172 T/C cg07460842 chr6:66804631 NA -0.51 -6.17 -0.35 2.6e-9 Metabolite levels; CESC cis rs2455799 0.613 rs11712323 chr3:15891360 T/C cg16303742 chr3:15540471 COLQ -0.35 -5.28 -0.31 2.66e-7 Mean platelet volume; CESC cis rs61931739 0.890 rs1705750 chr12:34142648 C/T cg19457237 chr12:34500585 NA -0.39 -5.34 -0.31 2e-7 Morning vs. evening chronotype; CESC cis rs7726839 0.794 rs11739663 chr5:594083 A/G cg16447950 chr5:562315 NA -0.5 -5.96 -0.34 7.92e-9 Obesity-related traits; CESC cis rs7809950 1.000 rs2237676 chr7:107198079 C/A cg23024343 chr7:107201750 COG5 -0.42 -5.89 -0.34 1.14e-8 Coronary artery disease; CESC cis rs7904368 0.659 rs3740169 chr10:16873547 C/T cg23933602 chr10:16859644 RSU1 0.62 7.03 0.4 1.7e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg22920501 chr2:26401640 FAM59B -0.67 -8.05 -0.44 2.82e-14 Gut microbiome composition (summer); CESC cis rs7359276 1 rs7359276 chr15:78892661 C/T cg24631222 chr15:78858424 CHRNA5 -0.82 -10.1 -0.53 1.7e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg05340658 chr4:99064831 C4orf37 0.84 13.14 0.63 1.04e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7223966 0.921 rs6504186 chr17:61863932 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.74 0.38 9.84e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg05564831 chr3:52568323 NT5DC2 0.45 6.72 0.38 1.13e-10 Bipolar disorder; CESC cis rs2404602 0.647 rs11632765 chr15:76974261 A/T cg23625390 chr15:77176239 SCAPER 0.46 6.44 0.37 5.6e-10 Blood metabolite levels; CESC cis rs6502050 0.805 rs4789720 chr17:80157490 G/C cg23985595 chr17:80112537 CCDC57 -0.39 -6.24 -0.36 1.76e-9 Life satisfaction; CESC cis rs12586317 0.924 rs4981276 chr14:35696818 A/G cg16230307 chr14:35515116 FAM177A1 0.76 7.94 0.44 5.78e-14 Psoriasis; CESC cis rs10206020 0.885 rs6720923 chr2:1574197 T/C cg26248373 chr2:1572462 NA -0.59 -6.93 -0.39 3.22e-11 IgG glycosylation; CESC cis rs155076 1.000 rs261423 chr13:21852331 A/C cg11317459 chr13:21872234 NA -1.05 -11.58 -0.58 2.37e-25 White matter hyperintensity burden; CESC cis rs5769707 0.935 rs5770594 chr22:50018497 G/A cg05373962 chr22:49881684 NA -0.38 -6.73 -0.38 1.04e-10 Monocyte count;Monocyte percentage of white cells; CESC cis rs12476592 0.602 rs6546004 chr2:63639529 T/C cg17519650 chr2:63277830 OTX1 -0.46 -5.08 -0.3 7.09e-7 Childhood ear infection; CESC cis rs5769765 0.908 rs9616213 chr22:50317851 T/G cg26441486 chr22:50317300 CRELD2 0.48 5.75 0.33 2.44e-8 Schizophrenia; CESC cis rs7809950 0.678 rs6949634 chr7:106984684 G/T cg23024343 chr7:107201750 COG5 -0.54 -6.99 -0.39 2.2e-11 Coronary artery disease; CESC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg00149659 chr3:10157352 C3orf10 0.69 7.84 0.43 1.13e-13 Alzheimer's disease; CESC cis rs17854409 0.803 rs3210314 chr20:61472117 C/A cg07645718 chr20:61493192 TCFL5 0.79 5.2 0.3 3.98e-7 Obesity-related traits; CESC cis rs8092503 1.000 rs2311117 chr18:52473793 A/G cg12377874 chr18:52495404 RAB27B 0.37 5.92 0.34 9.78e-9 Childhood body mass index; CESC cis rs9291683 0.588 rs3796829 chr4:10019138 C/G cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.14e-46 Bone mineral density; CESC cis rs9611519 0.590 rs4821980 chr22:41415479 C/G cg03806693 chr22:41940476 POLR3H -0.51 -6.05 -0.35 4.93e-9 Neuroticism; CESC cis rs7618501 0.521 rs55692411 chr3:49911155 G/A cg24308560 chr3:49941425 MST1R -0.65 -9.26 -0.49 7.13e-18 Intelligence (multi-trait analysis); CESC cis rs8180040 0.903 rs12487736 chr3:47459679 C/T cg27129171 chr3:47204927 SETD2 0.6 8.91 0.48 8.2e-17 Colorectal cancer; CESC cis rs2797160 1.000 rs1630556 chr6:126013155 A/G cg05901451 chr6:126070800 HEY2 0.46 6.56 0.37 2.81e-10 Endometrial cancer; CESC cis rs10883723 0.810 rs10883729 chr10:104273943 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.41 0.41 1.65e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs2797160 0.547 rs9401837 chr6:125956853 T/C cg05901451 chr6:126070800 HEY2 -0.39 -5.4 -0.32 1.45e-7 Endometrial cancer; CESC cis rs7607369 0.648 rs7559490 chr2:219656867 A/T cg02176678 chr2:219576539 TTLL4 -0.48 -8.21 -0.45 9.44e-15 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs1562975 0.609 rs62316329 chr4:109419399 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.42 5.39 0.31 1.54e-7 Height; CESC cis rs6121246 0.909 rs1075698 chr20:30387992 G/C cg13852791 chr20:30311386 BCL2L1 0.8 8.55 0.46 1.01e-15 Mean corpuscular hemoglobin; CESC cis rs7116495 1.000 rs3750908 chr11:71822401 A/G cg26138937 chr11:71823887 C11orf51 0.85 6.86 0.39 4.92e-11 Severe influenza A (H1N1) infection; CESC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg14562523 chr21:43528734 C21orf128;UMODL1 -0.39 -5.75 -0.33 2.48e-8 IgG glycosylation; CESC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg18758796 chr5:131593413 PDLIM4 0.43 5.91 0.34 1.03e-8 Breast cancer; CESC trans rs7746199 0.736 rs6904596 chr6:27491299 G/A cg06606381 chr12:133084897 FBRSL1 -0.98 -8.34 -0.46 4.16e-15 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs959260 1.000 rs9892325 chr17:73394449 A/C cg12999837 chr17:73267436 MIF4GD -0.53 -5.99 -0.35 6.65e-9 Systemic lupus erythematosus; CESC cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg24110177 chr3:50126178 RBM5 0.52 7.23 0.41 5.09e-12 Intelligence (multi-trait analysis); CESC cis rs950776 0.518 rs12916999 chr15:78826912 C/T cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs9443189 0.813 rs2748948 chr6:76437994 T/A cg01950844 chr6:76311363 SENP6 -0.65 -7.14 -0.4 8.95e-12 Prostate cancer; CESC trans rs4335177 0.762 rs2054980 chr9:109385024 T/C cg16874583 chr12:7781004 NA -0.46 -6.07 -0.35 4.37e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg21017887 chr14:105400489 NA 0.41 6.65 0.38 1.65e-10 Rheumatoid arthritis; CESC cis rs9911578 0.900 rs8067264 chr17:57182793 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.07 0.3 7.47e-7 Intelligence (multi-trait analysis); CESC cis rs35306767 0.953 rs12357633 chr10:957246 C/T cg25019033 chr10:957182 NA -0.6 -6.42 -0.37 6.2e-10 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00122254 chr1:46769320 LRRC41;UQCRH -0.59 -6.78 -0.38 7.61e-11 Gut microbiome composition (summer); CESC cis rs4689388 0.890 rs6446481 chr4:6295583 C/A cg14416269 chr4:6271139 WFS1 0.45 7.57 0.42 6.15e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs2321882 0.958 rs6561987 chr13:59394319 C/T cg20914879 chr14:56566808 NA -0.43 -6.17 -0.35 2.51e-9 Body mass index; CESC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs2074585 0.647 rs2601188 chr15:90929563 A/G cg22089800 chr15:90895588 ZNF774 -0.67 -9.49 -0.5 1.36e-18 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04640194 chr12:56754023 STAT2 -0.48 -6.38 -0.36 7.81e-10 Height; CESC cis rs11264213 0.901 rs72661643 chr1:36451599 A/G cg27506609 chr1:36549197 TEKT2 0.67 5.56 0.32 6.59e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01812826 chr8:123793836 ZHX2 0.58 6.77 0.38 8.09e-11 Gut microbiome composition (summer); CESC cis rs2637266 0.643 rs7914732 chr10:78476336 A/G cg18941641 chr10:78392320 NA 0.39 7.28 0.41 3.82e-12 Pulmonary function; CESC cis rs17539620 0.624 rs4566892 chr6:154837346 C/T cg20019720 chr6:154832845 CNKSR3 0.47 6.13 0.35 3.21e-9 Lipoprotein (a) levels; CESC cis rs796364 0.539 rs6738494 chr2:200697058 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.56 5.42 0.32 1.34e-7 Schizophrenia; CESC cis rs6582630 0.555 rs10785443 chr12:38463792 A/C cg13010199 chr12:38710504 ALG10B 0.43 5.69 0.33 3.35e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs875971 0.619 rs10278371 chr7:66051540 C/A cg26939375 chr7:64535504 NA -0.67 -8.95 -0.48 6.39e-17 Aortic root size; CESC cis rs1670533 1.000 rs6858612 chr4:1053353 C/T cg27284194 chr4:1044797 NA 0.45 5.8 0.34 1.85e-8 Recombination rate (females); CESC cis rs9399135 0.967 rs4376365 chr6:135307740 T/C cg22676075 chr6:135203613 NA 0.52 7.22 0.41 5.65e-12 Red blood cell count; CESC cis rs4523957 0.928 rs12949991 chr17:2197185 G/A cg16513277 chr17:2031491 SMG6 0.6 8.3 0.45 5.29e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7772486 0.875 rs2814869 chr6:146315509 G/A cg05347473 chr6:146136440 FBXO30 0.52 6.91 0.39 3.63e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg09913183 chr17:42254507 C17orf65;ASB16 0.56 6.9 0.39 3.86e-11 Total body bone mineral density; CESC cis rs7116495 1.000 rs517837 chr11:71802359 A/G cg10381502 chr11:71823885 C11orf51 -0.66 -5.4 -0.31 1.51e-7 Severe influenza A (H1N1) infection; CESC cis rs4566357 0.964 rs6436648 chr2:227923004 C/A cg11843606 chr2:227700838 RHBDD1 -0.42 -5.28 -0.31 2.76e-7 Coronary artery disease; CESC trans rs208520 1.000 rs12193164 chr6:66978962 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.33 0.5 4.5e-18 Exhaled nitric oxide output; CESC cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg03467027 chr4:99064603 C4orf37 0.43 5.47 0.32 1.03e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6831352 0.819 rs1230155 chr4:99989259 C/T cg12011299 chr4:100065546 ADH4 0.58 7.25 0.41 4.7e-12 Alcohol dependence; CESC cis rs2072499 0.833 rs2251636 chr1:156202809 G/C cg24450063 chr1:156163899 SLC25A44 0.9 15.07 0.68 1.72e-37 Testicular germ cell tumor; CESC cis rs9300255 0.544 rs1790130 chr12:123701270 A/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.5 -0.37 3.89e-10 Neutrophil percentage of white cells; CESC cis rs4253772 0.872 rs41362646 chr22:46633505 G/A cg00784671 chr22:46762841 CELSR1 -0.57 -5.62 -0.33 4.78e-8 LDL cholesterol;Cholesterol, total; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11642829 chr17:4607740 PELP1 -0.48 -6.34 -0.36 9.62e-10 Ulcerative colitis; CESC cis rs748404 0.518 rs480108 chr15:43817406 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.5 7.65 0.43 3.68e-13 Lung cancer; CESC cis rs3008870 1.000 rs1118393 chr1:67366668 A/G cg02640540 chr1:67518911 SLC35D1 0.48 5.18 0.3 4.32e-7 Lymphocyte percentage of white cells; CESC cis rs4950928 0.823 rs2494277 chr1:203168092 A/G cg14085262 chr1:203155938 CHI3L1 -0.47 -5.12 -0.3 5.89e-7 YKL-40 levels; CESC cis rs7539409 0.651 rs7521788 chr1:84309320 G/T cg10977910 chr1:84465055 TTLL7 0.8 7.69 0.43 2.9e-13 Alzheimer's disease; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg06859321 chr19:41643199 NA 0.46 6.42 0.37 6.22e-10 Prevalent atrial fibrillation; CESC cis rs6991838 0.557 rs7812390 chr8:66506217 A/G cg13398993 chr8:66546079 ARMC1 -0.47 -5.59 -0.32 5.56e-8 Intelligence (multi-trait analysis); CESC cis rs9486719 0.857 rs3798293 chr6:97033370 A/G cg18709589 chr6:96969512 KIAA0776 -0.46 -5.11 -0.3 6.27e-7 Migraine;Coronary artery disease; CESC cis rs8014204 0.901 rs2080087 chr14:75365062 C/T cg26191576 chr14:75389716 RPS6KL1 -0.38 -5.43 -0.32 1.29e-7 Caffeine consumption; CESC cis rs9916302 0.706 rs11657153 chr17:37699729 A/G cg20243544 chr17:37824526 PNMT 0.53 5.26 0.31 3.03e-7 Glomerular filtration rate (creatinine); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg11753193 chr8:94753277 RBM12B -0.45 -6.23 -0.36 1.82e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs34779708 0.966 rs1057108 chr10:35484949 T/G cg04310649 chr10:35416472 CREM -0.52 -6.34 -0.36 9.86e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs8141529 0.719 rs5762880 chr22:29287816 T/G cg15103426 chr22:29168792 CCDC117 0.6 7.75 0.43 1.97e-13 Lymphocyte counts; CESC cis rs7202877 0.656 rs977986 chr16:75506696 T/G cg04384234 chr16:75411784 CFDP1 -0.47 -5.65 -0.33 4.24e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs2276314 1.000 rs4799834 chr18:33566243 T/C cg05985134 chr18:33552581 C18orf21 0.63 7.42 0.41 1.6e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs727563 0.594 rs132807 chr22:42071584 T/C cg06481639 chr22:41940642 POLR3H 0.57 5.74 0.33 2.58e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg00080972 chr5:178986291 RUFY1 0.49 7.96 0.44 4.96e-14 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08926035 chr11:64521052 PYGM -0.53 -6.37 -0.36 8.31e-10 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.83 -0.55 7.31e-23 Alzheimer's disease; CESC cis rs7582720 1.000 rs72934735 chr2:203740010 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs16895831 0.549 rs3749900 chr6:42613379 A/G cg10605015 chr6:42532144 UBR2 -0.5 -5.52 -0.32 8.27e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs9303401 1.000 rs9303401 chr17:56847945 C/T cg12560992 chr17:57184187 TRIM37 0.49 5.54 0.32 7.42e-8 Cognitive test performance; CESC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg04553112 chr3:125709451 NA -0.51 -5.58 -0.32 5.94e-8 Blood pressure (smoking interaction); CESC cis rs4253772 0.550 rs6008598 chr22:46704243 C/T cg09491104 chr22:46646882 C22orf40 -0.51 -6.15 -0.35 2.76e-9 LDL cholesterol;Cholesterol, total; CESC cis rs8044868 0.548 rs12930702 chr16:72077000 C/G cg16558253 chr16:72132732 DHX38 -0.39 -6.08 -0.35 4.12e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs8067354 0.574 rs2250526 chr17:57951973 G/A cg02344993 chr17:57696989 CLTC 0.53 5.64 0.33 4.43e-8 Hemoglobin concentration; CESC cis rs2294693 0.947 rs9296351 chr6:40988102 T/C cg14418226 chr6:40996092 UNC5CL 0.43 5.51 0.32 8.4e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs694739 0.964 rs2510066 chr11:64052447 C/T cg23796481 chr11:64053134 BAD;GPR137 0.66 8.39 0.46 2.85e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg18758796 chr5:131593413 PDLIM4 -0.43 -5.84 -0.34 1.52e-8 Breast cancer; CESC trans rs1814175 0.616 rs1851848 chr11:49992254 G/C cg11707556 chr5:10655725 ANKRD33B -0.42 -6.16 -0.35 2.76e-9 Height; CESC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs16858210 0.826 rs35494670 chr3:183606357 T/G cg25686905 chr3:183603175 PARL -0.34 -6.23 -0.36 1.84e-9 Menopause (age at onset); CESC cis rs854765 0.547 rs7223696 chr17:17915791 G/T cg16928487 chr17:17741425 SREBF1 -0.57 -10.18 -0.53 8.98e-21 Total body bone mineral density; CESC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg16325326 chr1:53192061 ZYG11B 0.98 16.92 0.72 4.94e-44 Monocyte count; CESC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg11764359 chr7:65958608 NA 0.69 9.06 0.49 2.98e-17 Aortic root size; CESC cis rs11677370 0.561 rs12711973 chr2:3825339 C/G cg17052675 chr2:3827356 NA -0.42 -5.39 -0.31 1.54e-7 Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01856141 chr3:52804944 NEK4 -0.42 -6.5 -0.37 3.88e-10 Gambling; CESC trans rs12713956 0.748 rs550619 chr2:21260601 G/A cg13097573 chr17:47957986 NA -0.79 -6.06 -0.35 4.59e-9 LDL cholesterol; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26387956 chr15:41407860 INO80 -0.48 -6.15 -0.35 2.78e-9 Ulcerative colitis; CESC cis rs7107174 0.892 rs2512540 chr11:77979299 A/G cg02023728 chr11:77925099 USP35 0.48 6.63 0.38 1.82e-10 Testicular germ cell tumor; CESC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg11764359 chr7:65958608 NA 0.66 8.54 0.46 1.06e-15 Aortic root size; CESC cis rs1005224 0.853 rs6574251 chr14:76136883 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.44 -6.02 -0.35 5.77e-9 Large artery stroke; CESC cis rs7089973 0.585 rs7907837 chr10:116610690 G/T cg03647239 chr10:116582469 FAM160B1 0.48 6.17 0.35 2.52e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg15383120 chr6:291909 DUSP22 -0.68 -8.75 -0.47 2.47e-16 Menopause (age at onset); CESC cis rs8067354 0.574 rs1292042 chr17:57934995 A/G cg13753209 chr17:57696993 CLTC 0.53 5.7 0.33 3.13e-8 Hemoglobin concentration; CESC cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg25124228 chr12:125621409 AACS -0.53 -6.65 -0.38 1.66e-10 Post bronchodilator FEV1/FVC ratio; CESC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg26314531 chr2:26401878 FAM59B -0.77 -8.69 -0.47 3.87e-16 Gut microbiome composition (summer); CESC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg07395648 chr5:131743802 NA -0.46 -6.0 -0.35 6.55e-9 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03987003 chr1:145516092 GNRHR2;PEX11B 0.56 6.16 0.35 2.74e-9 Gut microbiome composition (summer); CESC cis rs9303401 0.703 rs9910629 chr17:57210301 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.59 7.75 0.43 2e-13 Cognitive test performance; CESC cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs798766 1.000 rs1665364 chr4:1727206 A/G cg10756475 chr4:1757242 NA -0.48 -6.45 -0.37 5.13e-10 Bladder cancer;Urinary bladder cancer; CESC cis rs10743315 0.557 rs74669613 chr12:19313696 T/C cg02471346 chr12:19282374 PLEKHA5 0.75 5.64 0.33 4.25e-8 Gut microbiota (bacterial taxa); CESC cis rs1062177 0.855 rs6896664 chr5:151265274 A/G cg00977110 chr5:151150581 G3BP1 0.51 5.85 0.34 1.45e-8 Preschool internalizing problems; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04408576 chr16:1524927 CLCN7 -0.45 -6.08 -0.35 4.1e-9 Fibrinogen levels; CESC cis rs11098499 0.954 rs3733524 chr4:120423729 T/C cg09307838 chr4:120376055 NA 0.93 12.84 0.62 1.19e-29 Corneal astigmatism; CESC cis rs116095464 1.000 rs62331562 chr5:349298 G/C cg22857025 chr5:266934 NA -0.83 -5.11 -0.3 6.24e-7 Breast cancer; CESC cis rs11997175 0.624 rs4593494 chr8:33692621 C/T ch.8.33884649F chr8:33765107 NA 0.48 5.87 0.34 1.33e-8 Body mass index; CESC cis rs2933343 0.729 rs6790091 chr3:128608751 G/C cg24203234 chr3:128598194 ACAD9 0.43 5.79 0.34 1.97e-8 IgG glycosylation; CESC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.72 0.38 1.09e-10 Prudent dietary pattern; CESC cis rs1499972 0.618 rs6795060 chr3:117642675 C/A cg07612923 chr3:117604196 NA 0.72 6.61 0.38 2.1e-10 Schizophrenia; CESC cis rs933688 1.000 rs6862125 chr5:90724598 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 1.0 13.06 0.63 2.05e-30 Smoking behavior; CESC cis rs7762018 0.891 rs1981069 chr6:170148837 G/A cg05834625 chr6:170176447 C6orf70 0.65 7.17 0.4 7.57e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg12963246 chr6:28129442 ZNF389 -0.55 -7.3 -0.41 3.37e-12 Depression; CESC cis rs28374715 0.532 rs11854632 chr15:41682094 A/G cg20272979 chr15:41787780 ITPKA -0.43 -5.4 -0.31 1.51e-7 Ulcerative colitis; CESC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.8 0.39 7.06e-11 Electroencephalogram traits; CESC cis rs1030268 0.607 rs34218501 chr7:133210375 G/A cg10665199 chr7:133106180 EXOC4 0.48 5.47 0.32 1.02e-7 Intelligence (multi-trait analysis); CESC cis rs6942756 1.000 rs6980385 chr7:128943615 G/A cg02491457 chr7:128862824 NA -0.69 -9.25 -0.49 7.51e-18 White matter hyperintensity burden; CESC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.74 0.33 2.6e-8 Bipolar disorder; CESC trans rs1814175 0.645 rs2140602 chr11:50022800 G/C cg11707556 chr5:10655725 ANKRD33B -0.42 -6.13 -0.35 3.1e-9 Height; CESC cis rs3780486 0.846 rs10813954 chr9:33137596 A/C cg13443165 chr9:33130375 B4GALT1 0.46 6.78 0.38 7.98e-11 IgG glycosylation; CESC cis rs3096299 0.838 rs3102384 chr16:89411661 T/G cg08822215 chr16:89438651 ANKRD11 -0.43 -6.19 -0.36 2.29e-9 Multiple myeloma (IgH translocation); CESC cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg16489826 chr6:160211363 TCP1;MRPL18 0.71 8.4 0.46 2.77e-15 Age-related macular degeneration (geographic atrophy); CESC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg16325326 chr1:53192061 ZYG11B -0.71 -11.85 -0.59 2.92e-26 Monocyte count; CESC cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.86 0.48 1.22e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 0.967 rs376097 chr6:167410878 A/G cg07741184 chr6:167504864 NA 0.3 5.52 0.32 8.06e-8 Crohn's disease; CESC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg19163074 chr7:65112434 INTS4L2 0.43 5.51 0.32 8.54e-8 Aortic root size; CESC cis rs12357919 0.542 rs3740471 chr10:105363289 T/C cg00126946 chr10:105363258 SH3PXD2A 0.6 8.53 0.46 1.14e-15 White matter hyperintensity burden; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25187967 chr11:77024606 NA -0.45 -6.02 -0.35 5.69e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg18180107 chr4:99064573 C4orf37 0.4 5.06 0.3 7.74e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9291683 0.595 rs35501905 chr4:10053431 C/T cg11266682 chr4:10021025 SLC2A9 0.66 13.28 0.63 3.46e-31 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13154104 chr2:10443632 HPCAL1 -0.57 -6.99 -0.39 2.27e-11 Gut microbiome composition (summer); CESC cis rs2073300 0.609 rs6137930 chr20:23376732 G/A cg16736954 chr20:23401023 NAPB 0.8 6.25 0.36 1.67e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg01171360 chr6:293285 DUSP22 -0.66 -8.58 -0.47 8.08e-16 Menopause (age at onset); CESC cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg12193833 chr17:30244370 NA -0.71 -6.53 -0.37 3.38e-10 Hip circumference adjusted for BMI; CESC trans rs763361 1.000 rs1790947 chr18:67527760 A/C cg04590956 chr2:70057467 GMCL1 0.45 6.01 0.35 6.05e-9 Type 1 diabetes; CESC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg12463550 chr7:65579703 CRCP -0.49 -6.21 -0.36 2.06e-9 Aortic root size; CESC trans rs1506636 0.886 rs6466878 chr7:123272278 T/C cg12383159 chr11:1262597 MUC5B 0.36 6.12 0.35 3.31e-9 Plateletcrit;Platelet count; CESC cis rs7264396 0.635 rs6058351 chr20:34486093 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -11.03 -0.56 1.54e-23 Total cholesterol levels; CESC cis rs2576037 0.901 rs2060416 chr18:44576240 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.43 5.66 0.33 3.9e-8 Personality dimensions; CESC cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg24110177 chr3:50126178 RBM5 -0.53 -7.35 -0.41 2.48e-12 Intelligence (multi-trait analysis); CESC cis rs7777484 0.534 rs2533886 chr7:2834869 C/T cg09658497 chr7:2847517 GNA12 -0.44 -6.82 -0.39 6.3e-11 Height; CESC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg08736216 chr1:53307985 ZYG11A -0.38 -5.93 -0.34 9.35e-9 Monocyte count; CESC cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg10523679 chr1:76189770 ACADM 0.63 6.08 0.35 4.14e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7998202 0.667 rs695163 chr13:113363300 G/A cg02820901 chr13:113351484 ATP11A 0.65 5.61 0.33 5.2e-8 Glycated hemoglobin levels; CESC cis rs17407555 0.606 rs3775945 chr4:10011996 A/T cg00071950 chr4:10020882 SLC2A9 -0.56 -5.73 -0.33 2.69e-8 Schizophrenia (age at onset); CESC cis rs1707322 0.752 rs28812624 chr1:46203736 T/A cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16975985 chr12:49524048 TUBA1B -0.47 -6.83 -0.39 5.79e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.57 -8.03 -0.44 3.29e-14 Platelet count; CESC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg04166393 chr7:2884313 GNA12 0.62 8.46 0.46 1.85e-15 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14107975 chr11:96076498 MAML2 0.57 6.91 0.39 3.63e-11 Gut microbiome composition (summer); CESC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg18512352 chr11:47633146 NA 0.54 8.0 0.44 3.78e-14 Subjective well-being; CESC cis rs7520050 0.966 rs12564541 chr1:46380237 G/A cg24296786 chr1:45957014 TESK2 0.44 5.52 0.32 8.12e-8 Red blood cell count;Reticulocyte count; CESC trans rs9951602 0.512 rs1599635 chr18:76643819 G/A cg02800362 chr5:177631904 HNRNPAB 0.62 8.1 0.45 1.96e-14 Obesity-related traits; CESC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg11764359 chr7:65958608 NA -0.67 -8.59 -0.47 7.69e-16 Calcium levels; CESC cis rs1003719 0.788 rs13050757 chr21:38465345 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs9916302 0.752 rs8071300 chr17:37508524 G/C cg07936489 chr17:37558343 FBXL20 0.89 9.69 0.51 3.45e-19 Glomerular filtration rate (creatinine); CESC cis rs9287719 0.649 rs9973374 chr2:10716384 C/T cg00105475 chr2:10696890 NA 0.38 5.25 0.31 3.08e-7 Prostate cancer; CESC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg16405210 chr4:1374714 KIAA1530 0.76 10.41 0.54 1.66e-21 Obesity-related traits; CESC cis rs6831352 0.918 rs29001232 chr4:100046654 G/C cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs4561483 0.801 rs4511557 chr16:11949458 T/C cg08843971 chr16:11963173 GSPT1 0.54 7.8 0.43 1.42e-13 Testicular germ cell tumor; CESC cis rs4523957 0.890 rs216222 chr17:2155701 T/A cg16513277 chr17:2031491 SMG6 0.57 7.69 0.43 2.83e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6088590 0.687 rs6088582 chr20:33286798 G/A cg06115741 chr20:33292138 TP53INP2 0.53 6.64 0.38 1.8e-10 Coronary artery disease; CESC cis rs67460515 0.892 rs10513564 chr3:161059762 A/G cg03342759 chr3:160939853 NMD3 -0.53 -7.63 -0.42 4.17e-13 Parkinson's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21694044 chr22:41215540 SLC25A17 -0.46 -6.18 -0.35 2.45e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20014778 chr1:229761614 URB2;TAF5L 0.62 7.39 0.41 1.88e-12 Gut microbiome composition (summer); CESC cis rs992157 0.661 rs17653757 chr2:219109364 G/C cg20019365 chr2:219134978 PNKD;AAMP 0.66 9.17 0.49 1.39e-17 Colorectal cancer; CESC cis rs7044106 0.762 rs10984972 chr9:123409864 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.8 0.34 1.85e-8 Hip circumference adjusted for BMI; CESC cis rs698833 0.886 rs698802 chr2:44697624 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.43 5.18 0.3 4.47e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs367615 0.679 rs10070786 chr5:108815081 T/G cg17395555 chr5:108820864 NA 0.66 11.23 0.57 3.41e-24 Colorectal cancer (SNP x SNP interaction); CESC cis rs6674176 1.000 rs11210937 chr1:44405563 T/C cg12908607 chr1:44402522 ARTN -0.45 -6.19 -0.36 2.34e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs12200560 0.505 rs1334318 chr6:97079610 A/G cg06623918 chr6:96969491 KIAA0776 -0.45 -5.83 -0.34 1.57e-8 Coronary heart disease; CESC cis rs6570726 0.905 rs388728 chr6:145816419 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.71 0.38 1.15e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg22903471 chr2:27725779 GCKR -0.55 -7.77 -0.43 1.69e-13 Total body bone mineral density; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg27094323 chr7:1216898 NA -0.38 -5.17 -0.3 4.62e-7 Longevity;Endometriosis; CESC cis rs4805272 0.539 rs1075733 chr19:29324460 C/T cg14983838 chr19:29218262 NA 0.46 5.45 0.32 1.16e-7 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs9875589 0.509 rs6768383 chr3:14076952 G/A cg19554555 chr3:13937349 NA -0.44 -5.62 -0.33 4.74e-8 Ovarian reserve; CESC cis rs78707713 0.560 rs2394563 chr10:71238618 G/A cg12610070 chr10:71211762 TSPAN15 -0.33 -6.85 -0.39 5.18e-11 Venous thromboembolism; CESC cis rs7267979 0.933 rs11699203 chr20:25435169 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.57 0.73 2.33e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs894734 1.000 rs894734 chr12:54319727 A/G cg17410650 chr12:54324560 NA -0.31 -5.4 -0.31 1.51e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CESC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11030122 0.702 rs67300156 chr11:3953949 C/T cg18678763 chr11:4115507 RRM1 -0.45 -6.05 -0.35 4.94e-9 Mean platelet volume;Platelet distribution width; CESC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg20203395 chr5:56204925 C5orf35 0.5 5.77 0.33 2.24e-8 Initial pursuit acceleration; CESC cis rs12618769 0.543 rs3769728 chr2:99103001 G/A cg10123293 chr2:99228465 UNC50 0.39 5.14 0.3 5.22e-7 Bipolar disorder; CESC cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.49 -5.49 -0.32 9.65e-8 Multiple sclerosis; CESC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.69 0.38 1.29e-10 Bipolar disorder; CESC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg19592336 chr6:28129416 ZNF389 0.52 7.22 0.41 5.5e-12 Depression; CESC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.39e-7 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27262702 chr16:88878803 APRT 0.55 6.42 0.37 6.09e-10 Gut microbiome composition (summer); CESC cis rs17539620 0.624 rs111868524 chr6:154839960 G/C cg17771515 chr6:154831774 CNKSR3 0.56 5.35 0.31 1.94e-7 Lipoprotein (a) levels; CESC cis rs8017423 0.630 rs4900038 chr14:90821677 A/G cg14092571 chr14:90743983 NA 0.45 6.82 0.39 6.23e-11 Mortality in heart failure; CESC cis rs4835473 0.771 rs4261935 chr4:144900904 C/T cg25736465 chr4:144833511 NA 0.41 6.14 0.35 2.97e-9 Immature fraction of reticulocytes; CESC cis rs34375054 0.526 rs117431213 chr12:125675271 C/G cg05341575 chr12:125625032 AACS -0.37 -5.39 -0.31 1.57e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs2730245 0.661 rs842696 chr7:158662698 T/C cg14689365 chr7:158441557 NCAPG2 0.42 5.26 0.31 2.98e-7 Height; CESC trans rs4843747 0.605 rs28399183 chr16:88107277 G/A cg26811252 chr16:29126840 RRN3P2 0.68 9.57 0.51 7.78e-19 Menopause (age at onset); CESC cis rs7674212 0.539 rs2866635 chr4:104121576 G/A cg16532752 chr4:104119610 CENPE -0.4 -5.46 -0.32 1.09e-7 Type 2 diabetes; CESC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg23978390 chr7:1156363 C7orf50 0.61 6.15 0.35 2.81e-9 Bronchopulmonary dysplasia; CESC cis rs6964587 0.869 rs13237856 chr7:91551788 G/A cg17063962 chr7:91808500 NA -0.53 -7.09 -0.4 1.21e-11 Breast cancer; CESC cis rs7520050 0.966 rs785489 chr1:46576390 A/G cg03146154 chr1:46216737 IPP -0.43 -5.57 -0.32 6.33e-8 Red blood cell count;Reticulocyte count; CESC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg05279229 chr7:1896384 MAD1L1 -0.39 -5.11 -0.3 6.13e-7 Bipolar disorder and schizophrenia; CESC cis rs9948 0.786 rs62156234 chr2:97436292 C/G cg01990225 chr2:97406019 LMAN2L -0.93 -7.53 -0.42 8.09e-13 Erectile dysfunction and prostate cancer treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25944898 chr11:64085532 PRDX5;TRMT112 0.6 6.65 0.38 1.68e-10 Gut microbiome composition (summer); CESC cis rs1568889 1.000 rs34140872 chr11:28335872 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.13 0.53 1.38e-20 Bipolar disorder; CESC cis rs3126085 0.877 rs4415568 chr1:152181207 G/A cg26876637 chr1:152193138 HRNR 0.48 5.44 0.32 1.21e-7 Atopic dermatitis; CESC cis rs2070433 0.851 rs1029231 chr21:47931653 A/G cg12379764 chr21:47803548 PCNT 0.47 5.76 0.33 2.34e-8 Lymphocyte counts; CESC cis rs911555 0.755 rs10148970 chr14:103892000 G/A cg24130564 chr14:104152367 KLC1 -0.53 -7.07 -0.4 1.34e-11 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg12963246 chr6:28129442 ZNF389 0.58 7.72 0.43 2.41e-13 Depression; CESC cis rs2243480 0.522 rs1638736 chr7:66092308 A/T cg08632164 chr7:65971372 NA -0.53 -5.17 -0.3 4.72e-7 Diabetic kidney disease; CESC cis rs67478160 0.643 rs2295141 chr14:104212949 T/C cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.06 -0.4 1.45e-11 Schizophrenia; CESC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.27e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg25427524 chr10:38739819 LOC399744 -0.64 -9.09 -0.49 2.36e-17 Extrinsic epigenetic age acceleration; CESC cis rs4660306 0.961 rs7546268 chr1:45965340 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.86e-13 Homocysteine levels; CESC trans rs9399401 1.000 rs972982 chr6:142666861 A/G cg09897639 chr1:178063342 RASAL2;LOC100302401 -0.45 -6.13 -0.35 3.11e-9 Chronic obstructive pulmonary disease; CESC cis rs7131987 0.903 rs7302129 chr12:29415280 A/T cg09582351 chr12:29534625 ERGIC2 -0.36 -5.67 -0.33 3.66e-8 QT interval; CESC cis rs62344088 0.590 rs62345236 chr5:283519 G/A cg10591111 chr5:226296 SDHA -0.72 -5.91 -0.34 1.03e-8 Asthma (childhood onset); CESC cis rs2204008 0.577 rs2623049 chr12:38018831 G/A cg26384229 chr12:38710491 ALG10B -0.53 -7.49 -0.42 1.06e-12 Bladder cancer; CESC cis rs9479482 0.967 rs1853664 chr6:150355266 A/G cg03788504 chr6:150331562 NA -0.31 -6.12 -0.35 3.41e-9 Alopecia areata; CESC cis rs2979489 0.891 rs2979504 chr8:30386641 C/T cg26383811 chr8:30366931 RBPMS -0.8 -9.94 -0.52 5.43e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg08027265 chr7:2291960 NA -0.45 -6.96 -0.39 2.75e-11 Bipolar disorder and schizophrenia; CESC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg18252515 chr7:66147081 NA -0.43 -5.59 -0.32 5.73e-8 Aortic root size; CESC cis rs1843834 0.611 rs1058360 chr2:225449242 A/T cg22509189 chr2:225307070 NA -0.42 -5.61 -0.33 4.97e-8 IgE levels in asthmatics (D.p. specific); CESC cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg14829155 chr15:31115871 NA -0.73 -9.66 -0.51 4.04e-19 Huntington's disease progression; CESC trans rs2593957 0.503 rs9850121 chr3:108739965 G/A cg20104688 chr17:76183078 TK1;AFMID -0.56 -6.07 -0.35 4.47e-9 Colorectal cancer (diet interaction); CESC cis rs12893668 0.581 rs34843146 chr14:104079864 G/A cg24130564 chr14:104152367 KLC1 -0.51 -6.4 -0.37 7.05e-10 Reticulocyte count; CESC cis rs7635838 0.686 rs347588 chr3:11287504 C/T cg00170343 chr3:11313890 ATG7 0.52 7.33 0.41 2.75e-12 HDL cholesterol; CESC cis rs1497406 0.590 rs3818162 chr1:16528600 G/A cg00949922 chr1:16514382 NA 0.41 5.63 0.33 4.64e-8 Gamma gluatamyl transferase levels;Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6433857 0.536 rs1971135 chr2:181351508 G/A cg23363182 chr2:181467187 NA -0.42 -5.93 -0.34 9.42e-9 Body mass index; CESC cis rs11122272 0.735 rs2486741 chr1:231516450 G/C cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs11098499 0.909 rs1546504 chr4:120241179 C/T cg09307838 chr4:120376055 NA 0.91 12.64 0.61 5.82e-29 Corneal astigmatism; CESC cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg13902645 chr11:5959945 NA -0.68 -8.03 -0.44 3.16e-14 DNA methylation (variation); CESC cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.47 -7.97 -0.44 4.85e-14 Hemoglobin concentration; CESC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20376421 chr12:56546193 MYL6B -0.47 -6.17 -0.35 2.55e-9 Ulcerative colitis; CESC trans rs116095464 0.558 rs10475136 chr5:232796 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.87 0.39 4.6e-11 Breast cancer; CESC cis rs6088580 0.634 rs6120642 chr20:33012531 A/G cg24642439 chr20:33292090 TP53INP2 0.53 6.95 0.39 2.87e-11 Glomerular filtration rate (creatinine); CESC trans rs1728785 1.000 rs1170436 chr16:68607486 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.67 8.11 0.45 1.92e-14 Ulcerative colitis; CESC cis rs7914558 1.000 rs1890184 chr10:104748459 A/C cg08650961 chr10:104748594 CNNM2 0.32 5.34 0.31 2.04e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9399401 0.626 rs3817928 chr6:142750516 A/G cg03128060 chr6:142623767 GPR126 0.37 6.23 0.36 1.82e-9 Chronic obstructive pulmonary disease; CESC cis rs3820928 0.845 rs2177596 chr2:227890283 A/T cg11843606 chr2:227700838 RHBDD1 -0.47 -6.17 -0.35 2.61e-9 Pulmonary function; CESC cis rs798554 0.704 rs798503 chr7:2789704 G/A cg09658497 chr7:2847517 GNA12 -0.36 -5.51 -0.32 8.61e-8 Height; CESC cis rs910316 0.935 rs175448 chr14:75591071 G/A cg16144293 chr14:75469539 EIF2B2 0.4 5.25 0.31 3.15e-7 Height; CESC cis rs3733585 0.624 rs7376154 chr4:9952587 C/A cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8072100 0.713 rs3871595 chr17:45511388 C/T cg25173405 chr17:45401733 C17orf57 -0.43 -5.43 -0.32 1.26e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs863345 0.604 rs11265010 chr1:158498853 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg22974920 chr21:40686053 BRWD1 -0.46 -5.74 -0.33 2.57e-8 Cognitive function; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10831391 chr10:3109765 PFKP -0.47 -6.31 -0.36 1.16e-9 Ulcerative colitis; CESC cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg03467027 chr4:99064603 C4orf37 0.44 5.44 0.32 1.2e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11677416 1.000 rs6542094 chr2:113528625 A/G cg27083787 chr2:113543245 IL1A 0.41 5.16 0.3 4.75e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg03934478 chr11:495069 RNH1 0.57 5.78 0.33 2.07e-8 Body mass index; CESC cis rs4474465 0.790 rs7481910 chr11:78264202 G/C cg27205649 chr11:78285834 NARS2 0.41 5.24 0.31 3.29e-7 Alzheimer's disease (survival time); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00543840 chr1:22213376 HSPG2 -0.45 -7.44 -0.42 1.39e-12 Gambling; CESC cis rs9650657 0.547 rs11250099 chr8:10818657 C/T cg21775007 chr8:11205619 TDH 0.38 5.46 0.32 1.09e-7 Neuroticism; CESC cis rs13191362 1.000 rs28360546 chr6:163210973 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.99 9.07 0.49 2.67e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2000999 0.514 rs35930480 chr16:72217681 G/A cg04254540 chr16:71951199 KIAA0174 -0.71 -6.1 -0.35 3.73e-9 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg15052019 chr19:19431593 KIAA0892;SF4 -0.4 -5.13 -0.3 5.54e-7 Tonsillectomy; CESC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg00149659 chr3:10157352 C3orf10 0.73 8.81 0.48 1.65e-16 Alzheimer's disease; CESC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg00166722 chr3:10149974 C3orf24 0.48 5.99 0.35 6.66e-9 Alzheimer's disease; CESC cis rs9303280 0.806 rs9907088 chr17:38035116 G/A cg20243544 chr17:37824526 PNMT 0.5 6.54 0.37 3.21e-10 Self-reported allergy; CESC trans rs11098499 0.954 rs7687843 chr4:120421211 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.81 0.52 1.36e-19 Corneal astigmatism; CESC cis rs1832871 0.711 rs6920506 chr6:158695017 T/A cg07165851 chr6:158734300 TULP4 0.57 5.97 0.34 7.78e-9 Height; CESC cis rs1707322 0.752 rs3811436 chr1:46125880 T/C cg05343316 chr1:45956843 TESK2 0.51 6.24 0.36 1.7e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6570726 0.846 rs453834 chr6:145886261 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.49 0.37 4.31e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg21280719 chr6:42927975 GNMT -0.3 -6.94 -0.39 3.09e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2635047 0.648 rs4986203 chr18:44597092 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 7.95 0.44 5.34e-14 Educational attainment; CESC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg07167872 chr1:205819463 PM20D1 0.76 12.94 0.62 5.37e-30 Menarche (age at onset); CESC cis rs11112613 0.713 rs11112591 chr12:105951620 C/T cg03607813 chr12:105948248 NA 0.6 7.41 0.41 1.69e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10992590 chr2:130940487 SMPD4;FAM128B 0.5 7.09 0.4 1.23e-11 Gut microbiota (bacterial taxa); CESC trans rs11039798 0.858 rs7121333 chr11:48332138 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.31 0.36 1.19e-9 Axial length; CESC cis rs863345 0.548 rs857687 chr1:158577998 T/C cg12129480 chr1:158549410 OR10X1 -0.28 -5.3 -0.31 2.41e-7 Pneumococcal bacteremia; CESC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC cis rs6543140 0.601 rs7558013 chr2:102992806 G/T cg04239558 chr2:103089729 SLC9A4 0.43 5.08 0.3 7.24e-7 Blood protein levels; CESC cis rs11122272 0.735 rs2790889 chr1:231520240 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.61 -0.42 4.66e-13 Hemoglobin concentration; CESC cis rs7824557 0.767 rs7837036 chr8:11175489 A/G cg21775007 chr8:11205619 TDH 0.49 7.0 0.39 2.15e-11 Retinal vascular caliber; CESC trans rs7819412 0.540 rs2409726 chr8:11043138 T/C cg06636001 chr8:8085503 FLJ10661 -0.53 -6.16 -0.35 2.7e-9 Triglycerides; CESC cis rs10489525 0.530 rs11102884 chr1:115612947 A/G cg01522456 chr1:115632236 TSPAN2 -0.4 -5.17 -0.3 4.67e-7 Autism; CESC cis rs72634258 0.554 rs12745962 chr1:7919825 C/T cg00042356 chr1:8021962 PARK7 0.59 5.65 0.33 4.15e-8 Inflammatory bowel disease; CESC cis rs2243480 1.000 rs422164 chr7:65586605 C/G cg13147721 chr7:65941812 NA -0.99 -9.4 -0.5 2.68e-18 Diabetic kidney disease; CESC trans rs11088226 0.681 rs4547609 chr21:33953542 G/A cg09050820 chr6:167586206 TCP10L2 0.91 8.89 0.48 9.91e-17 Gastritis; CESC trans rs61931739 0.500 rs56404399 chr12:34543101 A/G cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06790019 chr1:44435457 DPH2 -0.47 -6.6 -0.38 2.24e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2070433 0.556 rs8129460 chr21:47822544 C/T cg12379764 chr21:47803548 PCNT 0.63 7.22 0.41 5.43e-12 Lymphocyte counts; CESC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg05368731 chr17:41323189 NBR1 0.8 10.93 0.56 3.31e-23 Menopause (age at onset); CESC trans rs9354308 0.901 rs55832318 chr6:66560086 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 7.85 0.43 1.04e-13 Metabolite levels; CESC cis rs9916302 0.706 rs1877030 chr17:37740161 T/C cg20243544 chr17:37824526 PNMT 0.56 5.17 0.3 4.52e-7 Glomerular filtration rate (creatinine); CESC cis rs9488822 0.676 rs11153594 chr6:116354591 A/G cg15226275 chr6:116381976 FRK -0.26 -6.55 -0.37 2.9e-10 Cholesterol, total;LDL cholesterol; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17520942 chr15:93632611 RGMA 0.44 6.94 0.39 2.98e-11 Systemic lupus erythematosus; CESC cis rs787274 0.867 rs786983 chr9:115458629 T/C cg13803584 chr9:115635662 SNX30 0.51 5.2 0.3 4.01e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs2070488 0.861 rs2067082 chr3:38438182 C/G cg24069376 chr3:38537580 EXOG 0.47 8.3 0.45 5.34e-15 Electrocardiographic conduction measures; CESC cis rs1005277 0.522 rs289649 chr10:37975384 T/C cg00409905 chr10:38381863 ZNF37A -0.51 -7.08 -0.4 1.3e-11 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16901991 chr2:24272451 FKBP1B -0.65 -7.55 -0.42 6.83e-13 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 20.91 0.79 5.29e-58 Prudent dietary pattern; CESC cis rs17376456 0.932 rs3940842 chr5:93534858 C/A cg25358565 chr5:93447407 FAM172A 1.18 11.18 0.57 4.83e-24 Diabetic retinopathy; CESC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg21724239 chr8:58056113 NA 0.58 5.96 0.34 7.87e-9 Developmental language disorder (linguistic errors); CESC cis rs4780401 0.527 rs4780402 chr16:11839809 C/T cg01061890 chr16:11836724 TXNDC11 -0.54 -7.19 -0.4 6.51e-12 Rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13892647 chr9:37485877 POLR1E 0.69 7.68 0.43 3.06e-13 Gut microbiome composition (summer); CESC cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg05315796 chr3:52349193 DNAH1 0.42 6.63 0.38 1.84e-10 Bipolar disorder; CESC cis rs2735413 0.881 rs12920025 chr16:78083005 C/T cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs34779708 0.833 rs12777517 chr10:35473927 T/G cg03585969 chr10:35415529 CREM 0.76 10.13 0.53 1.3e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg03188948 chr7:1209495 NA 0.55 7.59 0.42 5.31e-13 Longevity;Endometriosis; CESC trans rs55704346 0.566 rs2292407 chr4:25393889 C/T cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs3617 0.652 rs7630552 chr3:52891570 G/C cg07507251 chr3:52567010 NT5DC2 -0.32 -5.33 -0.31 2.07e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC trans rs35365539 1 rs35365539 chr3:49794347 A/AC cg21659725 chr3:3221576 CRBN -0.83 -13.63 -0.64 2.04e-32 Blood protein levels; CESC cis rs62064224 0.589 rs9903650 chr17:30689370 T/A cg18200150 chr17:30822561 MYO1D 0.39 5.09 0.3 6.69e-7 Schizophrenia; CESC cis rs757110 0.866 rs5213 chr11:17408404 C/T cg01153817 chr11:17409509 KCNJ11 0.35 5.31 0.31 2.35e-7 Type 2 diabetes; CESC cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.48 5.1 0.3 6.62e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9911578 0.867 rs72628394 chr17:57121313 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -5.25 -0.31 3.18e-7 Intelligence (multi-trait analysis); CESC cis rs7772486 0.875 rs2180192 chr6:146322284 T/C cg23711669 chr6:146136114 FBXO30 0.86 12.47 0.61 2.22e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs6424115 0.830 rs2502992 chr1:24201919 T/C cg15997130 chr1:24165203 NA 0.39 5.09 0.3 6.8e-7 Immature fraction of reticulocytes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01790346 chr8:119634302 SAMD12 -0.47 -6.85 -0.39 5.14e-11 Gambling; CESC cis rs9435341 0.826 rs17496332 chr1:107546375 C/T cg09367891 chr1:107599246 PRMT6 -0.6 -7.02 -0.4 1.83e-11 Facial morphology (factor 21, depth of nasal alae); CESC cis rs870825 0.616 rs56844261 chr4:185632478 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.89 0.39 3.95e-11 Blood protein levels; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg17372223 chr3:52568218 NT5DC2 0.56 9.63 0.51 5e-19 Hemoglobin concentration; CESC cis rs9303401 0.555 rs8073699 chr17:57236317 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.66 8.46 0.46 1.79e-15 Cognitive test performance; CESC cis rs2288912 0.807 rs10423208 chr19:45453656 G/A cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.23e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg12193833 chr17:30244370 NA -0.5 -5.47 -0.32 1.02e-7 Hip circumference adjusted for BMI; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg09112190 chr21:44722858 NA -0.45 -6.2 -0.36 2.17e-9 Psoriatic arthritis; CESC trans rs7615952 0.736 rs9866347 chr3:125669925 C/T cg07211511 chr3:129823064 LOC729375 -0.86 -7.2 -0.4 6.33e-12 Blood pressure (smoking interaction); CESC cis rs2262909 1.000 rs2078089 chr19:22209753 A/T cg11619707 chr19:22235551 ZNF257 -0.35 -5.7 -0.33 3.19e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg15485101 chr11:133734466 NA 0.4 6.59 0.38 2.35e-10 Childhood ear infection; CESC cis rs4594175 0.926 rs9323207 chr14:51621908 A/G cg23942311 chr14:51606299 NA -0.4 -6.0 -0.35 6.47e-9 Cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg21983178 chr1:45120676 TMEM53 -0.52 -6.91 -0.39 3.51e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1499614 0.901 rs2178742 chr7:66197799 G/A cg13147721 chr7:65941812 NA -0.94 -8.9 -0.48 9.08e-17 Gout; CESC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg19592336 chr6:28129416 ZNF389 -0.6 -7.92 -0.44 6.46e-14 Parkinson's disease; CESC cis rs7086627 0.515 rs10887894 chr10:82209952 A/G cg00277334 chr10:82204260 NA -0.91 -15.92 -0.7 1.67e-40 Post bronchodilator FEV1; CESC cis rs2985684 0.894 rs8005990 chr14:50022248 G/A cg04989706 chr14:50066350 PPIL5 -0.44 -5.05 -0.3 8.21e-7 Carotid intima media thickness; CESC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg06873352 chr17:61820015 STRADA 0.74 13.19 0.63 7.17e-31 Prudent dietary pattern; CESC cis rs4843747 0.671 rs72818576 chr16:88111019 C/G cg06915872 chr16:87998081 BANP 0.44 5.22 0.31 3.64e-7 Menopause (age at onset); CESC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg12463550 chr7:65579703 CRCP 0.49 6.33 0.36 1.03e-9 Aortic root size; CESC cis rs2230307 0.536 rs522696 chr1:100476662 G/A cg24955406 chr1:100503596 HIAT1 0.55 5.48 0.32 9.85e-8 Carotid intima media thickness; CESC cis rs9649465 1.000 rs6951138 chr7:123362070 G/A cg04330084 chr7:123175371 IQUB -0.39 -5.23 -0.31 3.47e-7 Migraine; CESC cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg09035930 chr12:129282057 SLC15A4 0.69 9.12 0.49 1.96e-17 Systemic lupus erythematosus; CESC cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg12365402 chr11:9010492 NRIP3 0.42 7.05 0.4 1.51e-11 Hemoglobin concentration; CESC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg14338887 chr6:42928500 GNMT 0.36 5.32 0.31 2.25e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs6540559 0.543 rs664097 chr1:210422179 C/T cg23283495 chr1:209979779 IRF6 0.42 5.52 0.32 7.89e-8 Cleft lip with or without cleft palate; CESC cis rs854765 0.534 rs7207461 chr17:17949789 T/G cg04398451 chr17:18023971 MYO15A 0.74 10.81 0.55 8.17e-23 Total body bone mineral density; CESC cis rs7267979 0.565 rs6076364 chr20:25556801 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.69 -10.97 -0.56 2.46e-23 Liver enzyme levels (alkaline phosphatase); CESC cis rs9916302 0.861 rs7503514 chr17:37669884 G/C cg20243544 chr17:37824526 PNMT 0.48 6.1 0.35 3.71e-9 Glomerular filtration rate (creatinine); CESC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg22105103 chr4:187893119 NA 0.51 7.6 0.42 5.13e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs17253792 0.822 rs75437558 chr14:56066798 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.79 -0.38 7.45e-11 Putamen volume; CESC cis rs2191566 0.639 rs7257749 chr19:44548666 G/A cg20607764 chr19:44506953 ZNF230 -0.43 -5.52 -0.32 8.25e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs9549367 0.713 rs9549352 chr13:113833221 A/G cg18105134 chr13:113819100 PROZ -0.69 -8.18 -0.45 1.23e-14 Platelet distribution width; CESC cis rs28374715 0.662 rs10851403 chr15:41466087 T/G cg18705301 chr15:41695430 NDUFAF1 -0.78 -10.29 -0.53 4e-21 Ulcerative colitis; CESC cis rs3820928 0.874 rs13393902 chr2:227880554 A/G cg05526886 chr2:227700861 RHBDD1 -0.43 -5.48 -0.32 9.75e-8 Pulmonary function; CESC cis rs748404 0.697 rs471122 chr15:43558574 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.6 -7.65 -0.43 3.7e-13 Lung cancer; CESC cis rs2408955 0.522 rs10875721 chr12:48413593 A/G cg24011408 chr12:48396354 COL2A1 -0.58 -8.73 -0.47 2.83e-16 Glycated hemoglobin levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg13137891 chr2:60779450 BCL11A -0.47 -6.61 -0.38 2.05e-10 Asthma; CESC cis rs9768139 0.903 rs10262701 chr7:158114591 G/A cg24154853 chr7:158122151 PTPRN2 -0.38 -5.98 -0.34 7.19e-9 Calcium levels; CESC cis rs9303401 0.614 rs34683543 chr17:56520036 C/A cg25039879 chr17:56429692 SUPT4H1 0.53 5.47 0.32 1.05e-7 Cognitive test performance; CESC cis rs7116495 0.609 rs4477459 chr11:71720616 T/C cg07596299 chr11:71824057 C11orf51 -0.82 -5.33 -0.31 2.13e-7 Severe influenza A (H1N1) infection; CESC cis rs3820068 0.581 rs59684759 chr1:15919893 A/G cg17385448 chr1:15911702 AGMAT 0.41 6.59 0.38 2.36e-10 Systolic blood pressure; CESC cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00881883 chr6:42897299 CNPY3 0.58 6.13 0.35 3.09e-9 Gut microbiome composition (summer); CESC cis rs599083 0.530 rs686921 chr11:68170833 G/T cg01657329 chr11:68192670 LRP5 0.44 5.16 0.3 4.74e-7 Bone mineral density (spine); CESC cis rs9815354 0.812 rs73073358 chr3:41842527 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs2625529 0.526 rs11637611 chr15:72551712 C/T cg16672083 chr15:72433130 SENP8 0.43 6.48 0.37 4.54e-10 Red blood cell count; CESC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg11764359 chr7:65958608 NA -0.79 -11.33 -0.57 1.53e-24 Aortic root size; CESC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg25072359 chr17:41440525 NA 0.51 6.62 0.38 1.95e-10 Menopause (age at onset); CESC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg04267008 chr7:1944627 MAD1L1 -0.63 -7.72 -0.43 2.43e-13 Bipolar disorder and schizophrenia; CESC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg03517284 chr6:25882590 NA -0.48 -6.34 -0.36 1.01e-9 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11201273 chr8:38088865 DDHD2 0.59 6.43 0.37 5.88e-10 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg06873352 chr17:61820015 STRADA 0.48 7.0 0.4 2.07e-11 Height; CESC cis rs977987 0.806 rs12444589 chr16:75454404 A/T cg03315344 chr16:75512273 CHST6 -0.41 -6.03 -0.35 5.55e-9 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04925196 chr12:51592141 POU6F1 -0.59 -6.35 -0.36 9.29e-10 Gut microbiome composition (summer); CESC cis rs2730245 0.527 rs2527205 chr7:158706393 G/T cg24397884 chr7:158709396 WDR60 -0.7 -7.75 -0.43 1.96e-13 Height; CESC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.65 0.33 4.23e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2479106 0.824 rs1752169 chr9:126586563 C/A cg16191174 chr9:126692580 DENND1A 0.47 6.47 0.37 4.79e-10 Polycystic ovary syndrome; CESC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg11494091 chr17:61959527 GH2 0.39 5.21 0.3 3.86e-7 Height; CESC cis rs1267303 0.675 rs1745370 chr1:46982863 C/G cg25110126 chr1:46999211 NA -0.89 -9.86 -0.52 9.97e-20 Monobrow; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17930852 chr1:45957182 TESK2 -0.63 -6.7 -0.38 1.25e-10 Gut microbiome composition (summer); CESC cis rs11030122 0.702 rs10500590 chr11:3964724 T/C cg18678763 chr11:4115507 RRM1 -0.5 -6.64 -0.38 1.78e-10 Mean platelet volume;Platelet distribution width; CESC cis rs2354432 0.607 rs7553584 chr1:146693429 A/G cg25205988 chr1:146714368 CHD1L -1.19 -9.08 -0.49 2.58e-17 Mitochondrial DNA levels; CESC cis rs4664304 0.739 rs2162500 chr2:160708645 C/G cg03641300 chr2:160917029 PLA2R1 0.39 5.36 0.31 1.8e-7 Crohn's disease;Inflammatory bowel disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10730208 chr12:58290540 NA -0.44 -6.09 -0.35 3.93e-9 Gut microbiota (bacterial taxa); CESC cis rs11190604 1.000 rs4244338 chr10:102272802 A/G cg07080220 chr10:102295463 HIF1AN 0.67 6.22 0.36 1.91e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs9583531 0.689 rs9521905 chr13:111352600 G/A cg24331049 chr13:111365604 ING1 -0.75 -10.2 -0.53 7.79e-21 Coronary artery disease; CESC cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg17366294 chr4:99064904 C4orf37 0.55 7.61 0.42 4.88e-13 Colonoscopy-negative controls vs population controls; CESC cis rs9486719 1.000 rs12208884 chr6:96885572 G/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs360071 0.870 rs360074 chr1:226091150 A/G cg17950169 chr1:226067900 TMEM63A 0.31 5.03 0.3 9.23e-7 Response to radiotherapy in prostate cancer (toxicity, rectal bleeding); CESC trans rs1814175 0.817 rs1621090 chr11:49895868 C/A cg15704280 chr7:45808275 SEPT13 -1.03 -20.9 -0.79 5.71e-58 Height; CESC cis rs7520050 0.966 rs946529 chr1:46485548 G/T cg03146154 chr1:46216737 IPP -0.47 -6.03 -0.35 5.46e-9 Red blood cell count;Reticulocyte count; CESC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg11644478 chr21:40555479 PSMG1 1.04 17.8 0.74 3.62e-47 Cognitive function; CESC cis rs4523957 0.620 rs1565764 chr17:2074303 G/A cg16513277 chr17:2031491 SMG6 -0.77 -11.17 -0.57 5.39e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1538970 0.924 rs1006216 chr1:45909994 A/G cg24296786 chr1:45957014 TESK2 -0.46 -5.25 -0.31 3.14e-7 Platelet count; CESC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg02725872 chr8:58115012 NA -0.45 -6.84 -0.39 5.31e-11 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01108697 chr16:1812618 MAPK8IP3 -0.5 -6.06 -0.35 4.62e-9 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs1800344 chr16:89816367 T/G cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg22920501 chr2:26401640 FAM59B -0.68 -8.18 -0.45 1.21e-14 Gut microbiome composition (summer); CESC trans rs9325144 0.625 rs11534879 chr12:38968165 A/G cg23762105 chr12:34175262 ALG10 0.48 6.42 0.37 6.16e-10 Morning vs. evening chronotype; CESC cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.38 6.13 0.35 3.18e-9 Hemoglobin concentration; CESC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg25072359 chr17:41440525 NA 0.49 6.41 0.37 6.64e-10 Menopause (age at onset); CESC cis rs4969178 0.560 rs4969182 chr17:76393030 T/C cg05887092 chr17:76393375 PGS1 0.69 11.66 0.58 1.25e-25 HDL cholesterol levels; CESC cis rs9486719 0.901 rs13206547 chr6:97006942 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -8.3 -0.45 5.39e-15 Migraine;Coronary artery disease; CESC cis rs9621305 0.502 rs738684 chr22:32012634 C/T cg25791279 chr22:32026902 PISD 0.52 5.09 0.3 6.85e-7 Intelligence; CESC cis rs7408868 0.908 rs757474 chr19:15273624 T/C cg14696996 chr19:15285081 NOTCH3 1.11 11.47 0.58 5.57e-25 Pulse pressure; CESC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg18016565 chr1:150552671 MCL1 -0.33 -5.13 -0.3 5.71e-7 Tonsillectomy; CESC trans rs9929218 0.529 rs8059194 chr16:68749663 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.9 14.52 0.67 1.51e-35 Colorectal cancer; CESC cis rs7914558 0.966 rs1591915 chr10:104646849 C/T cg08650961 chr10:104748594 CNNM2 0.33 5.37 0.31 1.71e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg22823121 chr1:150693482 HORMAD1 0.37 5.19 0.3 4.1e-7 Melanoma; CESC cis rs4472734 1.000 rs4472734 chr1:214618185 C/T cg00063699 chr1:214624242 PTPN14 -0.34 -5.4 -0.32 1.46e-7 Height; CESC cis rs10876993 0.890 rs7976852 chr12:58100551 T/G cg18357645 chr12:58087776 OS9 0.64 10.5 0.54 8.52e-22 Celiac disease or Rheumatoid arthritis; CESC cis rs733175 0.857 rs10018663 chr4:10004797 C/T cg00071950 chr4:10020882 SLC2A9 0.51 5.85 0.34 1.41e-8 Psychosis and Alzheimer's disease; CESC trans rs1814175 0.616 rs10839388 chr11:49842603 C/T cg15704280 chr7:45808275 SEPT13 -0.98 -17.93 -0.74 1.3e-47 Height; CESC trans rs208520 0.661 rs6937856 chr6:66867468 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.89 -0.62 7.46e-30 Exhaled nitric oxide output; CESC cis rs5769707 0.632 rs1476037 chr22:49991377 G/A cg05373962 chr22:49881684 NA -0.35 -5.11 -0.3 6.07e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg18765753 chr7:1198926 ZFAND2A -0.6 -9.64 -0.51 4.91e-19 Longevity;Endometriosis; CESC cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.57 0.47 8.43e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.59 0.32 5.76e-8 Bipolar disorder; CESC cis rs9611565 0.580 rs5758449 chr22:42140160 C/T cg06634786 chr22:41940651 POLR3H 0.49 5.5 0.32 8.83e-8 Vitiligo; CESC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg19717773 chr7:2847554 GNA12 -0.57 -8.14 -0.45 1.52e-14 Height; CESC cis rs7223966 1.000 rs16947014 chr17:61719032 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.62 0.38 1.93e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg10845886 chr2:3471009 TTC15 -0.67 -9.29 -0.5 5.87e-18 Neurofibrillary tangles; CESC cis rs887829 0.588 rs4663969 chr2:234655313 C/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.53 -6.92 -0.39 3.34e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs6570726 0.846 rs4896824 chr6:145927048 C/T cg23711669 chr6:146136114 FBXO30 0.83 12.33 0.6 6.39e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs4727027 0.870 rs1534196 chr7:148790591 G/A cg23583168 chr7:148888333 NA -0.78 -12.16 -0.6 2.45e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02214188 chr4:104020949 BDH2 0.53 6.78 0.38 7.62e-11 Gut microbiota (bacterial taxa); CESC cis rs11958404 0.932 rs72818109 chr5:157438340 A/T cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs3892630 0.878 rs8112955 chr19:33191192 C/T cg22980127 chr19:33182716 NUDT19 1.02 11.58 0.58 2.23e-25 Red blood cell traits; CESC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.87e-8 Lung cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17976829 chr10:131934431 GLRX3 0.47 6.0 0.35 6.53e-9 Gut microbiota (bacterial taxa); CESC trans rs2727020 0.857 rs1917324 chr11:49371759 G/C cg15704280 chr7:45808275 SEPT13 -0.76 -9.47 -0.5 1.61e-18 Coronary artery disease; CESC cis rs3824867 0.920 rs9734013 chr11:47451517 G/T cg20307385 chr11:47447363 PSMC3 -0.47 -5.48 -0.32 9.68e-8 Mean corpuscular hemoglobin; CESC cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.66 6.21 0.36 2e-9 Lung function (FEV1/FVC); CESC cis rs3733585 0.699 rs62294331 chr4:9959889 A/G cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9291683 0.588 rs35866697 chr4:10018604 C/A cg11266682 chr4:10021025 SLC2A9 0.71 14.52 0.67 1.5e-35 Bone mineral density; CESC cis rs1152591 0.524 rs1255992 chr14:64662895 A/G cg21174375 chr14:64681225 SYNE2 0.56 7.88 0.44 8.58e-14 Atrial fibrillation; CESC cis rs10751667 0.600 rs14346 chr11:1011829 T/C cg06064525 chr11:970664 AP2A2 -0.33 -5.58 -0.32 6.04e-8 Alzheimer's disease (late onset); CESC cis rs4722166 0.695 rs7808122 chr7:22798080 A/G cg13104385 chr7:22767384 IL6 0.39 5.78 0.33 2.15e-8 Lung cancer; CESC cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.52 0.46 1.18e-15 Hip circumference adjusted for BMI; CESC cis rs7551222 0.752 rs12032733 chr1:204481209 G/A cg20240347 chr1:204465584 NA -0.28 -5.7 -0.33 3.27e-8 Schizophrenia; CESC cis rs10463316 0.862 rs10071166 chr5:150768795 T/C cg03212797 chr5:150827313 SLC36A1 -0.45 -5.78 -0.33 2.13e-8 Metabolite levels (Pyroglutamine); CESC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -5.53 -0.32 7.8e-8 Personality dimensions; CESC cis rs12579753 0.810 rs10862355 chr12:82162698 C/T cg21193143 chr12:82153300 PPFIA2 -0.33 -5.31 -0.31 2.38e-7 Resting heart rate; CESC cis rs858239 0.571 rs2390755 chr7:23190716 A/T cg23682824 chr7:23144976 KLHL7 0.51 6.8 0.39 6.75e-11 Cerebrospinal fluid biomarker levels; CESC cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg11752832 chr7:134001865 SLC35B4 0.52 6.61 0.38 2.14e-10 Mean platelet volume; CESC cis rs11098499 0.954 rs4577559 chr4:120404043 T/G cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.1e-8 Corneal astigmatism; CESC trans rs801193 0.935 rs11772264 chr7:66176387 T/C cg26939375 chr7:64535504 NA 0.64 8.76 0.47 2.31e-16 Aortic root size; CESC cis rs67460515 0.563 rs1585481 chr3:160901481 C/T cg03342759 chr3:160939853 NMD3 -0.54 -7.21 -0.4 5.86e-12 Parkinson's disease; CESC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs61776719 0.520 rs12569027 chr1:38449163 C/T cg17077180 chr1:38461687 NA 0.47 7.22 0.41 5.37e-12 Coronary artery disease; CESC cis rs6460942 0.915 rs62448619 chr7:12457743 C/T cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg05234568 chr11:5960015 NA -0.55 -6.36 -0.36 8.79e-10 DNA methylation (variation); CESC cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg11890956 chr21:40555474 PSMG1 1.17 21.04 0.79 1.8e-58 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05262316 chr6:64345491 NA -0.59 -6.99 -0.39 2.17e-11 Gut microbiome composition (summer); CESC cis rs116095464 1.000 rs10475185 chr5:306981 C/T cg22857025 chr5:266934 NA -1.25 -7.67 -0.43 3.19e-13 Breast cancer; CESC cis rs6089584 1.000 rs6142910 chr20:60562181 C/A cg13770153 chr20:60521292 NA -0.45 -5.9 -0.34 1.12e-8 Body mass index; CESC cis rs563538 1 rs563538 chr13:37433721 A/G cg18983090 chr13:37575004 EXOSC8 -0.69 -5.29 -0.31 2.6e-7 Spontaneous preterm birth (preterm birth); CESC cis rs10504229 0.679 rs16921623 chr8:58039473 G/C cg24829409 chr8:58192753 C8orf71 -0.49 -6.18 -0.36 2.35e-9 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13612175 chr14:69259241 ZFP36L1 -0.54 -6.48 -0.37 4.53e-10 Gut microbiome composition (summer); CESC trans rs7672847 0.547 rs72974740 chr4:170479434 T/C cg19308436 chr1:237949471 RYR2 0.65 7.03 0.4 1.79e-11 Subjective well-being; CESC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg12463550 chr7:65579703 CRCP -0.52 -6.48 -0.37 4.33e-10 Aortic root size; CESC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg17372223 chr3:52568218 NT5DC2 0.41 5.71 0.33 3.05e-8 Bipolar disorder; CESC cis rs6430585 0.640 rs6716070 chr2:136544651 G/T cg07169764 chr2:136633963 MCM6 -1.19 -17.18 -0.73 5.7e-45 Corneal structure; CESC cis rs3820928 1.000 rs7561378 chr2:227772248 T/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.74 -0.33 2.55e-8 Pulmonary function; CESC cis rs7927771 1.000 rs34128973 chr11:47851376 C/T cg18512352 chr11:47633146 NA -0.61 -9.51 -0.5 1.24e-18 Subjective well-being; CESC cis rs2929278 0.617 rs12908467 chr15:44047430 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -7.83 -0.43 1.16e-13 Schizophrenia; CESC trans rs12960505 0.506 rs1125627 chr18:51004270 C/T cg06077405 chr7:2313805 SNX8 -0.49 -6.17 -0.35 2.56e-9 Intelligence (multi-trait analysis); CESC cis rs1707322 1.000 rs11211190 chr1:46266255 C/T cg05343316 chr1:45956843 TESK2 0.42 5.2 0.3 3.95e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2797160 0.837 rs1739364 chr6:126022383 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.46 -6.3 -0.36 1.25e-9 Endometrial cancer; CESC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.57 5.61 0.33 4.98e-8 Cerebrospinal P-tau181p levels; CESC cis rs75477785 0.590 rs72649914 chr1:210077882 C/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.96 6.81 0.39 6.53e-11 Cleft lip with or without cleft palate; CESC trans rs10995245 0.840 rs4746525 chr10:64438271 A/G cg05827312 chr13:28394966 NA 0.34 6.1 0.35 3.81e-9 Narcolepsy; CESC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.46e-17 Gut microbiome composition (summer); CESC cis rs2637266 0.967 rs4553314 chr10:78358244 C/T cg18941641 chr10:78392320 NA 0.44 8.21 0.45 9.93e-15 Pulmonary function; CESC cis rs9747201 0.925 rs8072670 chr17:80159566 T/C cg09264619 chr17:80180166 NA -0.44 -5.22 -0.31 3.67e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg17650747 chr5:1873721 NA 0.43 6.13 0.35 3.22e-9 Cardiovascular disease risk factors; CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg15147215 chr3:52552868 STAB1 -0.29 -5.06 -0.3 7.67e-7 Electroencephalogram traits; CESC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg23758822 chr17:41437982 NA 1.03 15.87 0.7 2.47e-40 Menopause (age at onset); CESC cis rs1003719 0.591 rs2835633 chr21:38525019 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.56 -7.2 -0.4 6.24e-12 Eye color traits; CESC cis rs763014 0.931 rs2071980 chr16:626346 A/C cg07343612 chr16:622815 PIGQ -0.57 -8.24 -0.45 7.87e-15 Height; CESC cis rs6964587 0.692 rs2027950 chr7:91863700 C/G cg17063962 chr7:91808500 NA -0.45 -6.5 -0.37 3.9e-10 Breast cancer; CESC cis rs6570726 0.935 rs415590 chr6:145851244 T/C cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 1.98e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs2243480 1.000 rs1873494 chr7:65649899 T/C cg13147721 chr7:65941812 NA 0.97 9.16 0.49 1.47e-17 Diabetic kidney disease; CESC cis rs71277158 0.688 rs2287479 chr3:169787423 G/C cg04067573 chr3:169899625 PHC3 0.72 7.1 0.4 1.16e-11 Prostate cancer; CESC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg21747405 chr11:67723411 NA -0.44 -6.69 -0.38 1.3100000000000001e-10 Blood pressure (smoking interaction); CESC trans rs10841784 0.958 rs7962263 chr12:21466117 A/G cg00566759 chr18:28682345 DSC2 -0.48 -6.55 -0.37 2.95e-10 Childhood ear infection; CESC cis rs11997175 1.000 rs11997175 chr8:33770070 A/G ch.8.33884649F chr8:33765107 NA -0.61 -7.72 -0.43 2.42e-13 Body mass index; CESC cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg18904891 chr8:8559673 CLDN23 -0.67 -8.01 -0.44 3.64e-14 Obesity-related traits; CESC cis rs6493487 0.512 rs34874493 chr15:51312751 G/A cg02338191 chr15:51200825 AP4E1 0.58 5.47 0.32 1.02e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs12310956 0.532 rs1352210 chr12:33983187 A/G cg26384229 chr12:38710491 ALG10B 0.45 6.22 0.36 1.98e-9 Morning vs. evening chronotype; CESC cis rs9287719 0.967 rs6712304 chr2:10754375 A/C cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg03433033 chr1:76189801 ACADM 0.63 6.35 0.36 9.5e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs71277158 0.688 rs6808506 chr3:169839239 G/C cg04067573 chr3:169899625 PHC3 0.71 7.11 0.4 1.06e-11 Prostate cancer; CESC cis rs854765 0.647 rs8066764 chr17:17974668 C/T cg04398451 chr17:18023971 MYO15A -0.75 -11.02 -0.56 1.65e-23 Total body bone mineral density; CESC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg19346786 chr7:2764209 NA -0.48 -6.81 -0.39 6.5e-11 Height; CESC cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg17366294 chr4:99064904 C4orf37 0.57 7.98 0.44 4.33e-14 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06818126 chr11:68850279 TPCN2 -0.61 -6.68 -0.38 1.36e-10 Gut microbiome composition (summer); CESC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg04025307 chr7:1156635 C7orf50 0.45 5.04 0.3 8.56e-7 Bronchopulmonary dysplasia; CESC cis rs6121246 0.609 rs6060948 chr20:30376393 C/G cg13852791 chr20:30311386 BCL2L1 0.82 10.47 0.54 1.07e-21 Mean corpuscular hemoglobin; CESC cis rs3540 0.512 rs3862437 chr15:91084632 A/G cg22089800 chr15:90895588 ZNF774 -0.6 -7.74 -0.43 2.16e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26594522 chr4:1138272 NA -0.51 -6.05 -0.35 5e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27265637 chr10:75504303 SEC24C -0.64 -7.44 -0.42 1.41e-12 Gut microbiome composition (summer); CESC cis rs2070677 0.935 rs12242613 chr10:135419831 C/T cg20169779 chr10:135381914 SYCE1 -0.73 -9.56 -0.51 8.51e-19 Gout; CESC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg19622623 chr12:86230825 RASSF9 -0.48 -6.22 -0.36 1.91e-9 Major depressive disorder; CESC cis rs6460942 0.597 rs35589221 chr7:12535841 T/G cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs4423214 1.000 rs28364617 chr11:71159764 T/G cg24826892 chr11:71159390 DHCR7 0.47 5.55 0.32 6.97e-8 Vitamin D levels; CESC cis rs1200821 0.529 rs4934856 chr10:37807847 T/C cg25427524 chr10:38739819 LOC399744 0.42 5.43 0.32 1.27e-7 Hemostatic factors and hematological phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14330119 chr7:73668867 RFC2 0.54 6.39 0.37 7.29e-10 Gut microbiome composition (summer); CESC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg06636001 chr8:8085503 FLJ10661 -0.44 -5.58 -0.32 5.79e-8 Mood instability; CESC cis rs35110281 0.616 rs2236666 chr21:45109856 T/C cg21573476 chr21:45109991 RRP1B -0.58 -8.35 -0.46 3.84e-15 Mean corpuscular volume; CESC cis rs9457247 0.935 rs2757050 chr6:167377165 G/T cg23791538 chr6:167370224 RNASET2 0.6 8.57 0.47 8.75e-16 Crohn's disease; CESC cis rs1707322 1.000 rs4073847 chr1:46463012 A/C cg05343316 chr1:45956843 TESK2 -0.45 -5.46 -0.32 1.1e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11583043 0.708 rs3861735 chr1:101530191 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.52 5.5 0.32 8.99e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs6681460 0.966 rs10749763 chr1:67062126 G/A cg02459107 chr1:67143332 SGIP1 0.36 5.08 0.3 7.08e-7 Presence of antiphospholipid antibodies; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12703194 chr16:3086867 CCDC64B -0.46 -6.53 -0.37 3.35e-10 Fibrinogen levels; CESC cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg26677194 chr12:130822605 PIWIL1 0.61 7.48 0.42 1.12e-12 Menopause (age at onset); CESC trans rs877282 0.755 rs2790388 chr10:786084 T/C cg22713356 chr15:30763199 NA 1.09 11.81 0.59 3.82e-26 Uric acid levels; CESC cis rs2228479 0.850 rs17233497 chr16:89815152 G/A cg00800038 chr16:89945340 TCF25 -0.93 -6.34 -0.36 9.69e-10 Skin colour saturation; CESC cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg25405998 chr7:65216604 CCT6P1 0.51 5.71 0.33 2.95e-8 Aortic root size; CESC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg04346459 chr6:41068666 NFYA;LOC221442 0.4 5.54 0.32 7.36e-8 Alzheimer's disease (late onset); CESC cis rs7208859 0.673 rs216424 chr17:28943064 T/G cg04154034 chr17:28927549 LRRC37B2 0.72 6.35 0.36 9.3e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1538970 0.962 rs9429075 chr1:45818421 G/A cg05343316 chr1:45956843 TESK2 0.82 11.17 0.57 5.6e-24 Platelet count; CESC cis rs73019876 0.869 rs2359815 chr19:22187760 C/A cg11619707 chr19:22235551 ZNF257 -0.28 -5.03 -0.3 8.97e-7 Testicular germ cell tumor; CESC cis rs8058578 0.943 rs35629860 chr16:30671532 G/A cg02466173 chr16:30829666 NA -0.48 -7.34 -0.41 2.56e-12 Multiple myeloma; CESC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.95 -0.56 2.82e-23 Alzheimer's disease; CESC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.85 12.01 0.59 8.38e-27 Age-related macular degeneration (geographic atrophy); CESC cis rs6967414 0.579 rs11980762 chr7:6756878 G/A cg00387323 chr7:6746715 ZNF12 0.61 5.77 0.33 2.21e-8 Hematocrit;Hemoglobin concentration; CESC cis rs637571 0.522 rs556643 chr11:65733289 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.43 5.29 0.31 2.61e-7 Eosinophil percentage of white cells; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg03664139 chr6:101329504 ASCC3 -0.46 -6.07 -0.35 4.35e-9 Height; CESC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg16145915 chr7:1198662 ZFAND2A -0.4 -5.58 -0.32 5.92e-8 Longevity;Endometriosis; CESC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg06634786 chr22:41940651 POLR3H -0.67 -6.89 -0.39 4e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs78889164 0.876 rs3786893 chr19:33880000 C/G cg02272751 chr19:33882848 PEPD -0.54 -7.8 -0.43 1.39e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs11630290 0.592 rs11071769 chr15:64156842 G/C cg12036633 chr15:63758958 NA 0.45 5.45 0.32 1.14e-7 Iris characteristics; CESC cis rs6502050 0.835 rs35131307 chr17:80128439 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.61e-10 Life satisfaction; CESC cis rs9611565 0.592 rs9611613 chr22:41961831 T/C cg06634786 chr22:41940651 POLR3H -0.62 -6.87 -0.39 4.56e-11 Vitiligo; CESC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg03388025 chr16:89894329 SPIRE2 0.4 7.64 0.42 4.09e-13 Vitiligo; CESC trans rs11098499 0.675 rs11098534 chr4:120556772 T/G cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.52e-16 Corneal astigmatism; CESC cis rs67478160 0.655 rs4900598 chr14:104281541 T/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.08 -0.4 1.33e-11 Schizophrenia; CESC cis rs11098499 0.954 rs6820115 chr4:120398182 T/C cg09307838 chr4:120376055 NA 0.87 12.39 0.61 4.17e-28 Corneal astigmatism; CESC cis rs1707322 1.000 rs785480 chr1:46492164 C/G cg05343316 chr1:45956843 TESK2 0.44 5.44 0.32 1.22e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7772486 0.686 rs9497380 chr6:145955305 T/C cg05347473 chr6:146136440 FBXO30 0.53 6.89 0.39 3.99e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9549367 0.712 rs2316443 chr13:113864837 G/A cg18105134 chr13:113819100 PROZ -0.7 -9.09 -0.49 2.37e-17 Platelet distribution width; CESC cis rs1143633 0.530 rs2723163 chr2:113694339 A/G cg12858261 chr2:113808755 IL1F8 0.46 5.53 0.32 7.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs113835537 0.529 rs17496250 chr11:66270774 C/G cg24851651 chr11:66362959 CCS 0.48 5.75 0.33 2.42e-8 Airway imaging phenotypes; CESC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg12463550 chr7:65579703 CRCP -0.53 -6.77 -0.38 8.05e-11 Aortic root size; CESC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg07701084 chr6:150067640 NUP43 0.43 5.82 0.34 1.67e-8 Lung cancer; CESC cis rs9896933 0.832 rs75552659 chr17:80804630 G/A cg15369054 chr17:80825471 TBCD 0.48 5.06 0.3 8e-7 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs8040855 0.603 rs10520585 chr15:85661506 C/G cg08123816 chr15:85640762 PDE8A 0.37 5.12 0.3 5.93e-7 Bulimia nervosa; CESC cis rs4409675 0.619 rs12070173 chr1:28231955 G/C cg23691781 chr1:28212827 C1orf38 0.28 5.62 0.33 4.73e-8 Corneal astigmatism; CESC cis rs761746 0.672 rs5753684 chr22:31939973 A/G cg25791279 chr22:32026902 PISD 0.63 7.1 0.4 1.18e-11 Intelligence; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20540327 chr15:72668275 HEXA;C15orf34 0.49 6.39 0.37 7.63e-10 Gut microbiota (bacterial taxa); CESC cis rs7107174 1.000 rs2450123 chr11:77952771 T/C cg02023728 chr11:77925099 USP35 0.53 7.24 0.41 4.92e-12 Testicular germ cell tumor; CESC cis rs6831352 0.918 rs2602896 chr4:100046207 C/T cg12011299 chr4:100065546 ADH4 -0.6 -6.82 -0.39 6.28e-11 Alcohol dependence; CESC cis rs2933343 0.679 rs789229 chr3:128602526 C/T cg24203234 chr3:128598194 ACAD9 0.43 5.79 0.34 1.97e-8 IgG glycosylation; CESC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg11890956 chr21:40555474 PSMG1 -0.98 -15.95 -0.7 1.36e-40 Cognitive function; CESC cis rs9388451 0.513 rs1268069 chr6:126039994 A/C cg05901451 chr6:126070800 HEY2 -0.55 -8.1 -0.45 2.05e-14 Brugada syndrome; CESC cis rs11098499 0.866 rs9995136 chr4:120286845 A/G cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs9303401 0.659 rs16943326 chr17:57050365 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.98 12.47 0.61 2.09e-28 Cognitive test performance; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01246405 chr11:3876562 STIM1 -0.42 -6.17 -0.35 2.53e-9 Gambling; CESC cis rs7044106 0.708 rs959558 chr9:123368911 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.8 12.27 0.6 1.07e-27 Hip circumference adjusted for BMI; CESC cis rs7122539 0.734 rs4930391 chr11:66645254 A/G cg24851651 chr11:66362959 CCS -0.46 -6.61 -0.38 2.05e-10 HIV-1 susceptibility; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg26355472 chr1:47134199 ATPAF1 0.48 6.3 0.36 1.21e-9 Systemic lupus erythematosus; CESC cis rs3859192 0.599 rs34933056 chr17:38162983 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.61 9.08 0.49 2.59e-17 White blood cell count; CESC cis rs17362650 1.000 rs1056204 chr2:9647091 A/C cg12832956 chr2:9616023 IAH1 -0.52 -5.09 -0.3 6.69e-7 Alcohol dependence (age at onset); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07568437 chr12:123942694 SNRNP35 0.56 7.6 0.42 5.19e-13 Systemic lupus erythematosus; CESC cis rs933688 1.000 rs1964292 chr5:90743608 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 13.7 0.64 1.17e-32 Smoking behavior; CESC cis rs9287719 0.601 rs6751436 chr2:10723862 C/T cg00105475 chr2:10696890 NA 0.39 5.27 0.31 2.83e-7 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23222197 chr11:64578325 MEN1 0.52 6.28 0.36 1.37e-9 Gut microbiome composition (summer); CESC cis rs3747547 0.642 rs72726060 chr9:38082767 A/T cg13774184 chr9:37916125 SHB -0.63 -5.43 -0.32 1.25e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs1018836 0.668 rs9297857 chr8:91480964 A/C cg16814680 chr8:91681699 NA -0.62 -8.42 -0.46 2.37e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs12136530 0.774 rs2014772 chr1:19781247 C/T cg01832549 chr1:19774989 CAPZB -0.49 -6.71 -0.38 1.18e-10 Lead levels in blood; CESC cis rs12579753 0.879 rs12829053 chr12:82161926 T/A cg23701643 chr12:82153290 PPFIA2 -0.36 -5.1 -0.3 6.61e-7 Resting heart rate; CESC cis rs3820928 0.874 rs13403281 chr2:227880769 G/A cg05526886 chr2:227700861 RHBDD1 -0.41 -5.18 -0.3 4.49e-7 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06755612 chr14:45603778 FKBP3;FANCM 0.54 6.5 0.37 3.94e-10 Gut microbiome composition (summer); CESC trans rs9329221 0.620 rs6601427 chr8:10156025 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.2 -0.36 2.2e-9 Neuroticism; CESC cis rs3617 0.625 rs2245647 chr3:52862753 A/G cg07507251 chr3:52567010 NT5DC2 0.32 5.54 0.32 7.14e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18803079 chr1:64014643 EFCAB7;DLEU2L 0.49 6.56 0.37 2.83e-10 Fibrinogen levels; CESC trans rs6794880 0.778 rs12630839 chr3:84436203 A/G cg03554283 chr8:76319451 NA -0.56 -5.99 -0.35 6.66e-9 Body mass index (joint analysis main effects and smoking interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC trans rs10242455 0.702 rs73397499 chr7:99039627 T/C cg09045935 chr12:6379348 NA 0.91 7.16 0.4 7.89e-12 Blood metabolite levels; CESC cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs8067354 0.830 rs57510610 chr17:57889406 T/A cg13753209 chr17:57696993 CLTC 0.5 6.83 0.39 5.83e-11 Hemoglobin concentration; CESC cis rs3733585 0.673 rs4459990 chr4:9954005 T/C cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3096299 0.869 rs748941 chr16:89440754 T/A cg16743903 chr16:89593216 SPG7 -0.44 -5.6 -0.33 5.49e-8 Multiple myeloma (IgH translocation); CESC cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.850 rs117285117 chr16:89910250 T/G cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs17376456 0.825 rs10053405 chr5:93275403 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 -0.68 -5.43 -0.32 1.31e-7 Diabetic retinopathy; CESC cis rs2273669 0.667 rs12202145 chr6:109357829 A/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.694 rs7285041 chr22:41829149 G/T cg03806693 chr22:41940476 POLR3H 1.2 14.53 0.67 1.4e-35 Vitiligo; CESC cis rs2066819 1.000 rs17118439 chr12:56667604 C/T cg26734620 chr12:56694298 CS -0.92 -5.79 -0.34 2.01e-8 Psoriasis vulgaris; CESC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg11301795 chr4:187892539 NA 0.74 11.89 0.59 2.03e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs12410462 0.681 rs6681096 chr1:227609720 G/A cg04117972 chr1:227635322 NA 0.8 6.95 0.39 2.81e-11 Major depressive disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00882685 chr2:232528498 NA -0.44 -6.44 -0.37 5.47e-10 Asthma; CESC cis rs3008870 1.000 rs12137403 chr1:67437043 C/T cg02640540 chr1:67518911 SLC35D1 -0.5 -5.49 -0.32 9.53e-8 Lymphocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27343303 chr11:34380546 NA 0.49 6.48 0.37 4.35e-10 Gut microbiota (bacterial taxa); CESC cis rs16917546 0.935 rs10995271 chr10:64438486 G/C cg03961010 chr10:64397487 ZNF365 -0.35 -5.75 -0.33 2.43e-8 Basal cell carcinoma; CESC cis rs6783573 0.535 rs6442006 chr3:46629382 C/G cg21489266 chr3:46619131 LRRC2;TDGF1 -0.44 -6.08 -0.35 4.23e-9 Cerebrospinal fluid biomarker levels; CESC cis rs754466 0.561 rs11002343 chr10:79705871 G/A cg17075019 chr10:79541650 NA -0.68 -6.31 -0.36 1.16e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs17253792 0.822 rs112418863 chr14:56114079 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.65 0.33 4.2e-8 Putamen volume; CESC cis rs425277 0.917 rs262656 chr1:2088754 A/C cg24578937 chr1:2090814 PRKCZ 0.55 9.53 0.51 1.09e-18 Height; CESC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg26818010 chr10:134567672 INPP5A -0.91 -11.23 -0.57 3.39e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs873946 0.586 rs12783078 chr10:134569706 C/T cg26818010 chr10:134567672 INPP5A -0.94 -11.42 -0.57 7.99e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6089584 1.000 rs6089580 chr20:60558976 G/A cg24733560 chr20:60626293 TAF4 0.4 5.77 0.33 2.15e-8 Body mass index; CESC cis rs9790314 1.000 rs9872514 chr3:161042833 T/C cg03342759 chr3:160939853 NMD3 -0.53 -7.22 -0.41 5.58e-12 Morning vs. evening chronotype; CESC cis rs7772486 0.743 rs1292339 chr6:145967086 C/T cg23711669 chr6:146136114 FBXO30 -0.81 -11.85 -0.59 2.91e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs9595066 1.000 rs9595066 chr13:44706268 C/T cg04068111 chr13:44716778 NA -0.44 -6.5 -0.37 4.04e-10 Schizophrenia; CESC cis rs11626933 0.851 rs2282031 chr14:90730943 A/G cg14092571 chr14:90743983 NA -0.78 -12.16 -0.6 2.4e-27 Gut microbiota (bacterial taxa); CESC cis rs6087990 0.871 rs2424905 chr20:31352927 T/C cg13636640 chr20:31349939 DNMT3B 0.85 14.86 0.67 9.36e-37 Ulcerative colitis; CESC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg23283495 chr1:209979779 IRF6 0.54 6.32 0.36 1.1e-9 Cleft lip with or without cleft palate; CESC cis rs6502050 0.805 rs7406137 chr17:80084465 T/C cg01763666 chr17:80159506 CCDC57 0.36 5.05 0.3 8.07e-7 Life satisfaction; CESC cis rs11685299 1 rs11685299 chr2:225391296 C/A cg12698349 chr2:225449008 CUL3 0.76 11.0 0.56 1.91e-23 Schizophrenia; CESC cis rs3096299 0.967 rs2911253 chr16:89488587 T/G cg02034447 chr16:89574710 SPG7 0.41 5.22 0.31 3.58e-7 Multiple myeloma (IgH translocation); CESC cis rs9443189 0.570 rs9343316 chr6:76411800 G/A cg01950844 chr6:76311363 SENP6 0.88 9.29 0.5 6.05e-18 Prostate cancer; CESC cis rs7395581 0.797 rs10742801 chr11:47342220 A/C cg25783544 chr11:47291846 MADD 0.59 7.69 0.43 2.88e-13 HDL cholesterol; CESC cis rs1348850 0.914 rs2121430 chr2:178318375 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.69 9.48 0.5 1.48e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11249608 0.548 rs11960161 chr5:178453837 A/G cg21905437 chr5:178450457 ZNF879 0.6 8.72 0.47 3.05e-16 Pubertal anthropometrics; CESC cis rs17253792 0.822 rs10139905 chr14:56170031 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.69 5.94 0.34 8.99e-9 Putamen volume; CESC cis rs916888 0.773 rs199443 chr17:44819565 C/T cg27589368 chr17:43923255 LOC100128977;IMP5 -0.39 -5.49 -0.32 9.47e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs13040088 1.000 rs12480117 chr20:61558274 G/A cg23096297 chr20:61557774 DIDO1 1.03 11.02 0.56 1.75e-23 Menopause (age at onset); CESC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg27266027 chr21:40555129 PSMG1 0.46 5.43 0.32 1.25e-7 Cognitive function; CESC cis rs6430585 0.697 rs1050115 chr2:136511817 A/G cg07169764 chr2:136633963 MCM6 1.27 16.86 0.72 7.59e-44 Corneal structure; CESC cis rs2295359 0.724 rs10489630 chr1:67662622 G/T cg03340356 chr1:67600835 NA -0.3 -5.03 -0.3 9.23e-7 Psoriasis; CESC cis rs3820928 0.874 rs10202239 chr2:227901819 C/T cg11843606 chr2:227700838 RHBDD1 -0.5 -6.54 -0.37 3.09e-10 Pulmonary function; CESC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg25072359 chr17:41440525 NA 0.45 6.07 0.35 4.5e-9 Menopause (age at onset); CESC cis rs116095464 0.558 rs57335027 chr5:262907 A/G cg22857025 chr5:266934 NA -1.3 -18.55 -0.75 8.05e-50 Breast cancer; CESC cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg22467129 chr15:76604101 ETFA -0.39 -5.86 -0.34 1.39e-8 Blood metabolite levels; CESC cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg24642439 chr20:33292090 TP53INP2 -0.44 -5.2 -0.3 3.99e-7 Height; CESC cis rs6964587 1.000 rs7802668 chr7:91648939 A/G cg17063962 chr7:91808500 NA 0.58 8.02 0.44 3.36e-14 Breast cancer; CESC cis rs4790333 0.967 rs2002863 chr17:2269769 C/T cg02569219 chr17:2266849 SGSM2 0.45 5.54 0.32 7.19e-8 Proinsulin levels; CESC cis rs7095944 0.614 rs3824765 chr10:126433570 C/G cg08799069 chr10:126477246 METTL10 -0.37 -5.29 -0.31 2.58e-7 Asthma; CESC trans rs61931739 0.517 rs7958755 chr12:34294699 T/C cg26384229 chr12:38710491 ALG10B 0.62 8.67 0.47 4.48e-16 Morning vs. evening chronotype; CESC cis rs1008375 0.966 rs3796813 chr4:17591648 A/G cg02297831 chr4:17616191 MED28 0.5 6.18 0.35 2.4e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs79349575 0.783 rs4793991 chr17:47001801 A/G cg26022315 chr17:47021804 SNF8 0.39 5.18 0.3 4.5e-7 Type 2 diabetes; CESC cis rs939658 0.805 rs4778924 chr15:79443363 T/C cg17916960 chr15:79447300 NA -0.34 -5.74 -0.33 2.64e-8 Refractive error; CESC cis rs1475911 1.000 rs2839465 chr21:43511232 C/T cg14562523 chr21:43528734 C21orf128;UMODL1 -0.36 -5.34 -0.31 1.95e-7 IgG glycosylation; CESC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs10504229 0.773 rs60466370 chr8:58171248 A/C cg05313129 chr8:58192883 C8orf71 -0.46 -5.73 -0.33 2.74e-8 Developmental language disorder (linguistic errors); CESC trans rs7824557 0.510 rs4841524 chr8:11243126 C/G cg15556689 chr8:8085844 FLJ10661 -0.5 -6.14 -0.35 2.95e-9 Retinal vascular caliber; CESC cis rs6121246 0.738 rs2376996 chr20:30316667 T/A cg13852791 chr20:30311386 BCL2L1 0.8 8.55 0.46 1.02e-15 Mean corpuscular hemoglobin; CESC cis rs12887734 0.546 rs4900597 chr14:104266664 A/G cg08213375 chr14:104286397 PPP1R13B -0.41 -7.02 -0.4 1.87e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs5760092 0.755 rs4585126 chr22:24270005 T/C cg04234412 chr22:24373322 LOC391322 0.64 8.83 0.48 1.44e-16 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg05861140 chr6:150128134 PCMT1 -0.38 -5.52 -0.32 7.97e-8 Lung cancer; CESC cis rs8114671 0.869 rs6060199 chr20:33654773 A/G cg06115741 chr20:33292138 TP53INP2 -0.44 -5.31 -0.31 2.27e-7 Height; CESC cis rs6540556 0.723 rs1415542 chr1:209902110 T/C cg05527609 chr1:210001259 C1orf107 -0.66 -7.27 -0.41 3.94e-12 Red blood cell count; CESC trans rs7628583 0.877 rs12494731 chr3:64082003 G/T cg14419393 chr17:79953059 ASPSCR1 0.51 6.05 0.35 4.93e-9 Parental extreme longevity (95 years and older); CESC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg00149659 chr3:10157352 C3orf10 -1.05 -12.46 -0.61 2.34e-28 Alzheimer's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22159483 chr17:1588198 PRPF8 -0.44 -6.36 -0.36 8.8e-10 Gambling; CESC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.83 13.29 0.63 3.04e-31 Menarche (age at onset); CESC cis rs9309473 1.000 rs6753344 chr2:73653138 C/T cg20560298 chr2:73613845 ALMS1 0.51 6.57 0.37 2.7e-10 Metabolite levels; CESC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg08859206 chr1:53392774 SCP2 0.6 8.96 0.48 5.76e-17 Monocyte count; CESC cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg03467027 chr4:99064603 C4orf37 0.48 6.01 0.35 5.95e-9 Colonoscopy-negative controls vs population controls; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg03066081 chr17:77784036 NA -0.47 -6.38 -0.36 7.67e-10 Height; CESC cis rs5769765 0.955 rs2319465 chr22:50265784 A/C cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs1878931 0.507 rs4429296 chr16:3408277 T/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.71 -8.82 -0.48 1.57e-16 Body mass index (adult); CESC cis rs12079745 1.000 rs3766063 chr1:169154574 G/A cg09363564 chr1:169337483 NME7;BLZF1 -0.71 -5.51 -0.32 8.29e-8 QT interval; CESC cis rs28498503 0.573 rs59797828 chr18:76653107 C/T cg00806245 chr18:76673096 NA -0.68 -5.66 -0.33 3.98e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg23708337 chr7:1209742 NA 0.52 5.11 0.3 6.12e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs9467711 0.524 rs13216484 chr6:26762087 C/T cg01620082 chr3:125678407 NA -0.74 -6.32 -0.36 1.11e-9 Autism spectrum disorder or schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13355623 chr17:26898935 PIGS 0.48 6.45 0.37 5.23e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg13733410 chr7:12443478 VWDE 0.45 5.09 0.3 6.8e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09559324 chr16:31475905 ARMC5 -0.59 -6.41 -0.37 6.77e-10 Gut microbiome composition (summer); CESC cis rs644148 1.000 rs644148 chr19:44970935 T/G cg15540054 chr19:45004280 ZNF180 -0.72 -8.77 -0.47 2.23e-16 Personality dimensions; CESC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg25767906 chr1:53392781 SCP2 0.51 7.27 0.41 4.04e-12 Monocyte count; CESC cis rs757110 0.770 rs1557765 chr11:17403639 T/C cg15432903 chr11:17409602 KCNJ11 0.63 8.88 0.48 1.06e-16 Type 2 diabetes; CESC cis rs7659604 0.605 rs2071486 chr4:122740162 C/T cg20573242 chr4:122745356 CCNA2 0.75 10.17 0.53 1e-20 Type 2 diabetes; CESC cis rs760805 1.000 rs3845302 chr1:25259884 C/G cg22509179 chr1:25234806 RUNX3 -0.6 -8.55 -0.46 1.01e-15 Allergic disease (asthma, hay fever or eczema); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07509094 chr11:60674167 PRPF19 -0.45 -6.45 -0.37 5.2e-10 Gambling; CESC cis rs2000999 0.573 rs34139543 chr16:72158477 C/T cg04254540 chr16:71951199 KIAA0174 -0.74 -6.16 -0.35 2.76e-9 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08495027 chr22:31364830 MORC2;TUG1 0.48 6.2 0.36 2.15e-9 Gut microbiota (bacterial taxa); CESC cis rs6867032 0.527 rs9312971 chr5:2012888 C/A cg26168224 chr5:2018326 NA 0.72 12.15 0.6 2.62e-27 Gut microbiome composition (winter); CESC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg04414720 chr1:150670196 GOLPH3L 0.63 9.04 0.49 3.47e-17 Tonsillectomy; CESC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg07507251 chr3:52567010 NT5DC2 0.34 5.84 0.34 1.5e-8 Electroencephalogram traits; CESC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.08 10.6 0.55 3.94e-22 Platelet count; CESC cis rs6775745 0.654 rs10470437 chr3:131782733 A/T cg12213930 chr3:131751605 CPNE4 0.45 5.19 0.3 4.22e-7 Neutrophil count; CESC trans rs12310956 0.532 rs35366144 chr12:33992000 C/G cg26384229 chr12:38710491 ALG10B 0.58 8.09 0.45 2.13e-14 Morning vs. evening chronotype; CESC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg26314531 chr2:26401878 FAM59B 0.55 6.65 0.38 1.66e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09998692 chr4:83934395 LIN54 0.59 6.51 0.37 3.64e-10 Gut microbiome composition (summer); CESC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg05332525 chr7:65337924 VKORC1L1 0.47 5.56 0.32 6.64e-8 Aortic root size; CESC cis rs1018836 0.798 rs4735295 chr8:91671608 C/A cg16814680 chr8:91681699 NA -0.89 -13.93 -0.65 1.85e-33 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg10691866 chr7:65817282 TPST1 0.31 5.23 0.31 3.43e-7 Aortic root size; CESC cis rs2299587 0.554 rs2073566 chr8:17743655 G/A cg08627089 chr8:17753878 FGL1 -0.4 -5.76 -0.33 2.37e-8 Economic and political preferences; CESC cis rs67311347 0.955 rs6599100 chr3:40447362 C/T cg01475735 chr3:40494733 NA -0.42 -5.34 -0.31 2e-7 Renal cell carcinoma; CESC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg23161317 chr6:28129485 ZNF389 0.38 5.35 0.31 1.92e-7 Parkinson's disease; CESC cis rs7264396 0.616 rs6142476 chr20:34581216 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.49 5.77 0.33 2.21e-8 Total cholesterol levels; CESC cis rs1570884 0.516 rs9535268 chr13:50175478 C/A cg08779649 chr13:50194554 NA 0.39 6.71 0.38 1.17e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs7542091 0.669 rs7540534 chr1:210044824 A/T cg21951975 chr1:209979733 IRF6 0.47 8.25 0.45 7.51e-15 Monobrow; CESC cis rs4843747 0.709 rs72818521 chr16:88058751 C/G cg17633681 chr16:88106987 BANP 0.7 8.57 0.47 8.97e-16 Menopause (age at onset); CESC cis rs12474201 0.925 rs1058157 chr2:46988275 G/A cg06386533 chr2:46925753 SOCS5 0.88 12.19 0.6 1.92e-27 Height; CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg07507251 chr3:52567010 NT5DC2 -0.33 -6.13 -0.35 3.22e-9 Electroencephalogram traits; CESC cis rs7914558 0.966 rs746293 chr10:104897254 G/T cg04362960 chr10:104952993 NT5C2 0.46 5.92 0.34 9.98e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg19077165 chr18:44547161 KATNAL2 -0.6 -8.97 -0.48 5.73e-17 Personality dimensions; CESC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg12718519 chr1:2058417 PRKCZ 0.26 5.59 0.32 5.64e-8 Height; CESC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg00750074 chr16:89608354 SPG7 -0.45 -6.49 -0.37 4.19e-10 Multiple myeloma (IgH translocation); CESC cis rs71277158 0.688 rs7651554 chr3:169768485 C/G cg04067573 chr3:169899625 PHC3 0.51 5.29 0.31 2.51e-7 Prostate cancer; CESC trans rs4349753 0.640 rs28509278 chr5:144088800 C/T cg25299750 chr6:35109124 TCP11 0.49 6.04 0.35 5.06e-9 Photic sneeze reflex; CESC cis rs4803468 0.763 rs17318596 chr19:41937095 A/G cg14132834 chr19:41945861 ATP5SL -0.65 -7.89 -0.44 7.72e-14 Height; CESC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.53 -0.37 3.4e-10 Bipolar disorder; CESC cis rs4728302 0.869 rs6955240 chr7:133581873 G/A cg10665199 chr7:133106180 EXOC4 0.4 5.51 0.32 8.66e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs910316 1.000 rs175426 chr14:75624134 C/T cg16144293 chr14:75469539 EIF2B2 0.39 5.19 0.3 4.09e-7 Height; CESC cis rs11583043 0.708 rs12754497 chr1:101571888 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.49 -5.35 -0.31 1.86e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs734999 0.588 rs10910099 chr1:2533552 G/T cg18854424 chr1:2615690 NA -0.28 -5.41 -0.32 1.44e-7 Ulcerative colitis; CESC cis rs546131 0.928 rs558967 chr11:34827168 T/A cg06937548 chr11:34938143 PDHX;APIP 0.49 6.24 0.36 1.7e-9 Lung disease severity in cystic fibrosis; CESC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 13.27 0.63 3.72e-31 Platelet count; CESC cis rs7772486 0.790 rs9403756 chr6:146257761 C/G cg05347473 chr6:146136440 FBXO30 -0.52 -6.64 -0.38 1.75e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg21984481 chr17:79567631 NPLOC4 0.35 5.52 0.32 8.09e-8 Eye color traits; CESC cis rs76525880 0.538 rs9221 chr17:46675813 C/T cg06593406 chr17:46696139 NA -0.65 -6.16 -0.35 2.76e-9 Colorectal or endometrial cancer; CESC cis rs2242116 0.796 rs9852082 chr3:46972377 T/C cg27129171 chr3:47204927 SETD2 0.54 6.87 0.39 4.7e-11 Birth weight; CESC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.36 0.36 9.03e-10 Bipolar disorder; CESC cis rs17666538 0.535 rs1669658 chr8:607380 A/G cg07234876 chr8:600039 NA 0.84 6.25 0.36 1.62e-9 IgG glycosylation; CESC cis rs1048238 0.506 rs848195 chr1:16286522 A/G cg22431228 chr1:16359049 CLCNKA 0.36 6.39 0.37 7.32e-10 Systolic blood pressure; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14212983 chr1:21985742 RAP1GAP -0.49 -6.62 -0.38 1.99e-10 Ulcerative colitis; CESC cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg16489826 chr6:160211363 TCP1;MRPL18 0.77 9.45 0.5 1.84e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs637571 0.607 rs574586 chr11:65697083 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.47 5.72 0.33 2.83e-8 Eosinophil percentage of white cells; CESC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg22800045 chr5:56110881 MAP3K1 -0.67 -7.89 -0.44 8.06e-14 Initial pursuit acceleration; CESC cis rs763014 0.966 rs7198877 chr16:661439 A/G cg00908189 chr16:619842 PIGQ 0.62 8.6 0.47 6.86e-16 Height; CESC cis rs9443189 0.763 rs2647411 chr6:76433692 C/T cg01950844 chr6:76311363 SENP6 -0.64 -7.1 -0.4 1.14e-11 Prostate cancer; CESC cis rs77741769 0.571 rs12371178 chr12:121309129 T/C cg02419362 chr12:121203948 SPPL3 0.34 5.59 0.32 5.6e-8 Mean corpuscular volume; CESC cis rs17125944 0.505 rs80211268 chr14:53265483 C/G cg00686598 chr14:53173677 PSMC6 1.41 11.85 0.59 2.77e-26 Alzheimer's disease (late onset); CESC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg11843238 chr5:131593191 PDLIM4 0.36 5.11 0.3 6.06e-7 Breast cancer; CESC cis rs4253772 0.591 rs12167567 chr22:46659942 G/C cg09491104 chr22:46646882 C22orf40 -0.57 -8.72 -0.47 3.18e-16 LDL cholesterol;Cholesterol, total; CESC cis rs7829975 0.714 rs7823757 chr8:8670177 T/A cg17143192 chr8:8559678 CLDN23 0.42 5.24 0.31 3.28e-7 Mood instability; CESC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg04546413 chr19:29218101 NA 0.56 7.91 0.44 6.84e-14 Methadone dose in opioid dependence; CESC cis rs2243480 1.000 rs1723270 chr7:65469830 T/G cg18252515 chr7:66147081 NA -1.21 -11.82 -0.59 3.44e-26 Diabetic kidney disease; CESC cis rs9905704 0.918 rs302880 chr17:56761411 C/T cg12560992 chr17:57184187 TRIM37 0.59 7.04 0.4 1.67e-11 Testicular germ cell tumor; CESC cis rs9911578 1.000 rs9904879 chr17:56864422 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.24 0.31 3.23e-7 Intelligence (multi-trait analysis); CESC trans rs7618501 1.000 rs4855867 chr3:49745822 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.44 -0.46 2.11e-15 Intelligence (multi-trait analysis); CESC cis rs2463822 0.583 rs7129536 chr11:62030829 C/T cg06239285 chr11:62104954 ASRGL1 -1.03 -8.31 -0.45 5.01e-15 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9787249 0.957 rs12086750 chr1:40210468 G/C cg02773041 chr1:40204384 PPIE 0.54 7.68 0.43 3.02e-13 Blood protein levels; CESC trans rs9325144 0.625 rs12227353 chr12:38734542 C/T cg23762105 chr12:34175262 ALG10 0.48 6.23 0.36 1.81e-9 Morning vs. evening chronotype; CESC cis rs2996428 0.561 rs2275827 chr1:3746585 T/G cg10555106 chr1:3691387 LOC388588 0.37 5.4 0.31 1.46e-7 Red cell distribution width; CESC cis rs3780486 0.846 rs10758192 chr9:33131651 G/A cg13443165 chr9:33130375 B4GALT1 0.45 6.46 0.37 5e-10 IgG glycosylation; CESC cis rs9399135 0.935 rs987690 chr6:135350379 A/G cg24558204 chr6:135376177 HBS1L 0.52 7.29 0.41 3.48e-12 Red blood cell count; CESC cis rs9303401 0.632 rs7222087 chr17:57221619 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.55 7.27 0.41 4.06e-12 Cognitive test performance; CESC cis rs3008870 1.000 rs3008859 chr1:67390999 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.03 0.68 2.49e-37 Lymphocyte percentage of white cells; CESC cis rs1670533 1.000 rs10003009 chr4:1050849 G/A cg27284194 chr4:1044797 NA 0.44 5.49 0.32 9.49e-8 Recombination rate (females); CESC cis rs7937682 0.883 rs566647 chr11:111466607 A/G cg09085632 chr11:111637200 PPP2R1B 0.9 11.89 0.59 2.01e-26 Primary sclerosing cholangitis; CESC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg24675658 chr1:53192096 ZYG11B 0.64 7.96 0.44 5.13e-14 Monocyte count; CESC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg19468946 chr17:37922297 IKZF3 -0.39 -5.09 -0.3 6.82e-7 Glomerular filtration rate (creatinine); CESC cis rs7680126 0.500 rs4697717 chr4:10149784 C/G cg11266682 chr4:10021025 SLC2A9 -0.5 -6.36 -0.36 8.85e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg23978390 chr7:1156363 C7orf50 0.57 5.91 0.34 1.04e-8 Bronchopulmonary dysplasia; CESC cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6547741 0.935 rs4665384 chr2:27848397 A/G cg27432699 chr2:27873401 GPN1 0.49 6.77 0.38 8.27e-11 Oral cavity cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00090103 chr1:155920763 ARHGEF2 -0.56 -6.2 -0.36 2.19e-9 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg00149659 chr3:10157352 C3orf10 0.7 8.25 0.45 7.27e-15 Alzheimer's disease; CESC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.48 0.64 7.04e-32 Prudent dietary pattern; CESC cis rs7507204 0.767 rs12982509 chr19:3412057 C/T cg08380311 chr19:3435252 NFIC -0.6 -6.69 -0.38 1.33e-10 Height; CESC cis rs4073221 0.520 rs13065273 chr3:18194852 T/C cg07694806 chr3:18168406 NA -0.69 -5.62 -0.33 4.77e-8 Parkinson's disease; CESC cis rs1878931 0.535 rs55732163 chr16:3411518 A/C cg02880119 chr16:3481970 NA 0.43 5.47 0.32 1.06e-7 Body mass index (adult); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18764291 chr5:122110994 SNX2 -0.46 -6.23 -0.36 1.87e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2074585 0.708 rs2601190 chr15:90932966 A/C cg10434728 chr15:90938212 IQGAP1 0.44 8.25 0.45 7.51e-15 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs11122272 0.667 rs2244992 chr1:231537220 T/C cg06096015 chr1:231504339 EGLN1 0.42 6.07 0.35 4.33e-9 Hemoglobin concentration; CESC cis rs2455799 0.594 rs11928773 chr3:15925135 A/G cg16303742 chr3:15540471 COLQ -0.37 -5.73 -0.33 2.7e-8 Mean platelet volume; CESC cis rs6570726 0.791 rs621382 chr6:145799144 T/C cg05347473 chr6:146136440 FBXO30 0.57 7.34 0.41 2.59e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2439831 0.717 rs2470132 chr15:43835481 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.8 8.65 0.47 5.16e-16 Lung cancer in ever smokers; CESC cis rs72781680 0.582 rs72783611 chr2:24291445 C/T cg06627628 chr2:24431161 ITSN2 -0.67 -6.48 -0.37 4.54e-10 Lymphocyte counts; CESC cis rs892961 0.899 rs66749226 chr17:75412826 G/A cg05865280 chr17:75406074 SEPT9 0.62 12.43 0.61 2.89e-28 Airflow obstruction; CESC cis rs2295499 0.660 rs11490068 chr4:2639106 A/C cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.23 -0.31 3.4e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs67311347 0.544 rs1902073 chr3:40333497 C/T cg09455208 chr3:40491958 NA 0.35 6.27 0.36 1.43e-9 Renal cell carcinoma; CESC cis rs2404602 0.735 rs11857015 chr15:76649390 T/C cg00316803 chr15:76480434 C15orf27 0.38 5.24 0.31 3.27e-7 Blood metabolite levels; CESC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg16325326 chr1:53192061 ZYG11B 0.9 15.4 0.69 1.16e-38 Monocyte count; CESC cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg18876405 chr7:65276391 NA -0.65 -8.77 -0.47 2.18e-16 Aortic root size; CESC cis rs644799 0.930 rs587123 chr11:95560539 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.56 6.8 0.39 6.73e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg15541040 chr2:3486749 NA -0.43 -5.48 -0.32 1.01e-7 Neurofibrillary tangles; CESC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg22105103 chr4:187893119 NA 0.47 6.73 0.38 1.07e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs62229266 0.804 rs2255858 chr21:37412752 T/C cg12218747 chr21:37451666 NA -0.41 -5.77 -0.33 2.15e-8 Mitral valve prolapse; CESC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs13223928 0.592 rs4722439 chr7:3155858 C/T cg19214707 chr7:3157722 NA 0.42 5.85 0.34 1.46e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs7208859 0.673 rs9895684 chr17:29242600 G/A cg19761014 chr17:28927070 LRRC37B2 0.72 5.7 0.33 3.12e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg16339924 chr4:17578868 LAP3 -0.58 -7.53 -0.42 8.15e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs73072330 1.000 rs17729010 chr3:47912703 A/G cg09665691 chr3:47563885 NA -0.8 -5.36 -0.31 1.79e-7 Stem cell growth factor beta levels; CESC cis rs3106136 0.903 rs67552174 chr4:95203097 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.72 -0.38 1.14e-10 Capecitabine sensitivity; CESC cis rs9815354 1.000 rs56158380 chr3:41885588 G/A cg03022575 chr3:42003672 ULK4 0.58 6.01 0.35 5.96e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg26597838 chr10:835615 NA 1.16 11.37 0.57 1.12e-24 Eosinophil percentage of granulocytes; CESC cis rs6547741 1.000 rs6706610 chr2:27778091 G/A cg21248554 chr2:27665150 KRTCAP3 0.25 5.21 0.31 3.71e-7 Oral cavity cancer; CESC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg02034447 chr16:89574710 SPG7 0.47 5.99 0.35 6.7e-9 Multiple myeloma (IgH translocation); CESC cis rs9811920 0.809 rs4928151 chr3:99767553 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.45 -7.5 -0.42 9.66e-13 Axial length; CESC cis rs1609391 0.543 rs9859810 chr3:136629986 A/G cg15507776 chr3:136538369 TMEM22 0.81 11.89 0.59 2.08e-26 Neuroticism; CESC cis rs9394159 0.583 rs6457738 chr6:33617464 C/T cg14003231 chr6:33640908 ITPR3 -0.42 -7.68 -0.43 3.05e-13 Graves' disease; CESC cis rs10779751 1.000 rs11121702 chr1:11293147 C/T cg08854313 chr1:11322531 MTOR 0.79 10.67 0.55 2.4e-22 Body mass index; CESC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs4604732 0.631 rs11490200 chr1:247625915 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11640734 0.619 rs2293586 chr16:89962394 A/G cg00800038 chr16:89945340 TCF25 -0.6 -6.48 -0.37 4.48e-10 Interleukin-17 levels; CESC cis rs8028182 0.636 rs12708519 chr15:75803200 T/C cg20655648 chr15:75932815 IMP3 0.48 5.87 0.34 1.3e-8 Sudden cardiac arrest; CESC cis rs3733585 0.638 rs17185835 chr4:9958180 T/G cg11266682 chr4:10021025 SLC2A9 -0.6 -11.09 -0.56 1.01e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs71277158 0.688 rs7631178 chr3:169766424 G/T cg04067573 chr3:169899625 PHC3 -0.48 -5.06 -0.3 7.88e-7 Prostate cancer; CESC cis rs644799 1.000 rs7749 chr11:95565789 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.73 0.47 2.87e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs6951245 0.554 rs10246354 chr7:1132456 C/T cg13565492 chr6:43139072 SRF -0.7 -8.12 -0.45 1.8e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg00825309 chr19:58991885 ZNF446 -0.58 -8.21 -0.45 9.46e-15 Uric acid clearance; CESC cis rs7772486 0.686 rs9399564 chr6:146078907 C/T cg23711669 chr6:146136114 FBXO30 -0.89 -13.4 -0.64 1.33e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs3733585 0.673 rs6843873 chr4:9958788 A/C cg11266682 chr4:10021025 SLC2A9 -0.6 -11.19 -0.57 4.73e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7259376 0.869 rs6511346 chr19:22537574 T/C cg02657401 chr19:22469223 NA -0.26 -5.08 -0.3 7.07e-7 Menopause (age at onset); CESC cis rs7267979 0.966 rs2151144 chr20:25414924 G/C cg08601574 chr20:25228251 PYGB -0.36 -5.08 -0.3 7.02e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs6964587 1.000 rs10228334 chr7:91713972 C/T cg17063962 chr7:91808500 NA 0.57 7.92 0.44 6.54e-14 Breast cancer; CESC cis rs8016982 1.000 rs12147118 chr14:81652975 A/C cg01989461 chr14:81687754 GTF2A1 -0.53 -6.84 -0.39 5.57e-11 Schizophrenia; CESC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg24642844 chr7:1081250 C7orf50 -0.75 -9.03 -0.49 3.61e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9303401 0.659 rs12602389 chr17:56779778 G/A cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.8 0.34 1.85e-8 Tonsillectomy; CESC cis rs2228479 0.681 rs7196840 chr16:89959647 A/G cg00800038 chr16:89945340 TCF25 -0.63 -7.0 -0.4 2.1e-11 Skin colour saturation; CESC cis rs2243480 1.000 rs313831 chr7:65551226 C/T cg12463550 chr7:65579703 CRCP 0.7 5.41 0.32 1.4e-7 Diabetic kidney disease; CESC cis rs7615952 0.551 rs6438945 chr3:125634473 G/A cg05084668 chr3:125655381 ALG1L -0.49 -5.52 -0.32 8e-8 Blood pressure (smoking interaction); CESC cis rs453301 0.686 rs3989373 chr8:8911308 G/T cg15556689 chr8:8085844 FLJ10661 -0.48 -6.04 -0.35 5.13e-9 Joint mobility (Beighton score); CESC cis rs2046867 0.818 rs17690720 chr3:72866030 T/C cg25664220 chr3:72788482 NA -0.45 -6.63 -0.38 1.85e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC trans rs7716219 0.731 rs7704138 chr5:54944262 C/T cg16867680 chr6:47382645 NA 0.41 6.45 0.37 5.33e-10 Height; CESC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.27 0.41 4.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg00475322 chr7:917719 C7orf20 -0.45 -5.05 -0.3 8.27e-7 Cerebrospinal P-tau181p levels; CESC trans rs74054849 0.850 rs6674904 chr1:16013448 A/T cg06826283 chr7:600452 PRKAR1B 0.7 6.25 0.36 1.66e-9 Alcoholic chronic pancreatitis; CESC cis rs73206853 0.609 rs7306167 chr12:110892449 A/G cg12870014 chr12:110450643 ANKRD13A 0.63 5.18 0.3 4.34e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs4077515 0.874 rs3812575 chr9:139293259 T/C cg14169450 chr9:139327907 INPP5E 0.39 5.57 0.32 6.2e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs11711311 0.955 rs11715350 chr3:113418376 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.6 7.82 0.43 1.22e-13 IgG glycosylation; CESC cis rs6460942 0.730 rs7780477 chr7:12233750 G/C cg06484146 chr7:12443880 VWDE -0.47 -5.22 -0.31 3.54e-7 Coronary artery disease; CESC cis rs1707322 1.000 rs785486 chr1:46575148 G/C cg03146154 chr1:46216737 IPP -0.69 -9.13 -0.49 1.84e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25263898 chr1:36774223 C1orf113 -0.66 -7.5 -0.42 9.68e-13 Gut microbiome composition (summer); CESC cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg02487422 chr3:49467188 NICN1 0.4 5.08 0.3 6.98e-7 Parkinson's disease; CESC cis rs1577917 0.958 rs12213331 chr6:86504797 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.45 -0.37 5.18e-10 Response to antipsychotic treatment; CESC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.61 7.94 0.44 5.84e-14 Prudent dietary pattern; CESC cis rs938554 0.612 rs13113918 chr4:9998493 A/G cg00071950 chr4:10020882 SLC2A9 0.62 7.37 0.41 2.23e-12 Blood metabolite levels; CESC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg13393036 chr8:95962371 TP53INP1 -0.53 -11.65 -0.58 1.3e-25 Type 2 diabetes; CESC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg08704250 chr15:31115839 NA -0.68 -9.07 -0.49 2.76e-17 Huntington's disease progression; CESC cis rs9649465 1.000 rs3779260 chr7:123348315 A/G cg04330084 chr7:123175371 IQUB 0.38 5.18 0.3 4.49e-7 Migraine; CESC cis rs3862260 0.509 rs10754416 chr1:120163531 A/G cg11530693 chr1:120165357 ZNF697 0.68 10.52 0.54 7.68e-22 Systemic lupus erythematosus; CESC cis rs11792861 0.816 rs744980 chr9:111690388 C/T cg13535736 chr9:111863775 C9orf5 -0.46 -6.09 -0.35 3.87e-9 Menarche (age at onset); CESC cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.34 0.31 2.01e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs258892 0.841 rs266425 chr5:72132531 T/C cg21869765 chr5:72125136 TNPO1 0.44 5.68 0.33 3.61e-8 Small cell lung carcinoma; CESC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg00802000 chr16:706648 WDR90 -0.41 -6.25 -0.36 1.66e-9 Height; CESC cis rs2635047 1.000 rs2277717 chr18:44702718 C/A cg24371990 chr18:44770781 NA 0.32 5.04 0.3 8.56e-7 Educational attainment; CESC cis rs4253772 0.591 rs6008362 chr22:46652737 G/A cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.49 5.15 0.3 5.12e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9905704 0.918 rs390524 chr17:56674173 A/G cg12560992 chr17:57184187 TRIM37 0.6 6.95 0.39 2.8e-11 Testicular germ cell tumor; CESC cis rs16866061 1.000 rs34345163 chr2:225459080 A/G cg12698349 chr2:225449008 CUL3 0.74 10.31 0.53 3.62e-21 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01382900 chr6:13615583 NOL7 0.58 6.39 0.37 7.33e-10 Gut microbiome composition (summer); CESC cis rs7520050 0.966 rs10789487 chr1:46420221 G/A cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.54e-8 Red blood cell count;Reticulocyte count; CESC cis rs12541635 0.966 rs55729609 chr8:107056034 A/C cg10147462 chr8:107024639 NA 0.43 6.01 0.35 6.12e-9 Age of smoking initiation; CESC trans rs1814175 0.791 rs10839395 chr11:49846274 G/T cg03929089 chr4:120376271 NA -0.91 -15.2 -0.68 5.94e-38 Height; CESC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs897080 0.589 rs1067380 chr2:44646834 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.89 0.34 1.14e-8 Height; CESC cis rs2228479 0.850 rs11648689 chr16:89806732 G/A cg04013166 chr16:89971882 TCF25 0.79 6.72 0.38 1.12e-10 Skin colour saturation; CESC cis rs6541297 1.000 rs6682741 chr1:230279090 T/C cg20703242 chr1:230279135 GALNT2 0.68 10.84 0.55 6.89e-23 Coronary artery disease; CESC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.71 0.38 1.19e-10 Bipolar disorder; CESC cis rs9831754 0.906 rs7611939 chr3:78392751 A/C cg06138941 chr3:78371609 NA -0.65 -7.71 -0.43 2.58e-13 Calcium levels; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg02386725 chr1:162467755 UHMK1 0.43 6.06 0.35 4.55e-9 Bronchopulmonary dysplasia; CESC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg13147721 chr7:65941812 NA 0.37 5.06 0.3 7.87e-7 Aortic root size; CESC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.34e-7 Life satisfaction; CESC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg05896524 chr21:47604654 C21orf56 0.43 5.57 0.32 6.14e-8 Testicular germ cell tumor; CESC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg24829409 chr8:58192753 C8orf71 -0.64 -8.53 -0.46 1.18e-15 Developmental language disorder (linguistic errors); CESC cis rs5753618 0.539 rs4820962 chr22:31689951 A/G cg13145458 chr22:31556086 RNF185 0.48 5.42 0.32 1.33e-7 Colorectal cancer; CESC cis rs34779708 0.733 rs7087099 chr10:35541982 C/T cg04310649 chr10:35416472 CREM -0.48 -5.45 -0.32 1.12e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs11711311 0.955 rs10934241 chr3:113394705 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.66 8.53 0.46 1.11e-15 IgG glycosylation; CESC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -12.68 -0.61 3.95e-29 Gut microbiome composition (summer); CESC cis rs6499255 1.000 rs12596679 chr16:69822680 A/G cg15192750 chr16:69999425 NA -0.47 -5.94 -0.34 9e-9 IgE levels; CESC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.44 -5.2 -0.3 4e-7 Breast cancer; CESC cis rs12618769 0.597 rs72820002 chr2:99075259 T/A cg10123293 chr2:99228465 UNC50 0.41 5.42 0.32 1.36e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02466749 chr9:98054877 FANCC -0.58 -6.29 -0.36 1.32e-9 Gut microbiome composition (summer); CESC cis rs7259376 0.840 rs1808668 chr19:22518657 A/G cg02657401 chr19:22469223 NA -0.25 -5.2 -0.3 3.97e-7 Menopause (age at onset); CESC cis rs2760061 0.626 rs2527614 chr1:228126470 A/G cg01973587 chr1:228161476 NA 0.38 5.84 0.34 1.54e-8 Diastolic blood pressure; CESC cis rs965469 1.000 rs1331215 chr20:3376565 T/C cg25506879 chr20:3388711 C20orf194 -0.57 -5.97 -0.34 7.44e-9 IFN-related cytopenia; CESC cis rs897984 0.568 rs56083427 chr16:30881298 C/T cg02466173 chr16:30829666 NA -0.47 -6.87 -0.39 4.6e-11 Dementia with Lewy bodies; CESC cis rs9430161 0.645 rs12081186 chr1:11034195 T/C cg02454025 chr1:11042201 C1orf127 0.99 16.1 0.7 3.84e-41 Ewing sarcoma; CESC cis rs314370 0.904 rs314373 chr7:100456595 G/A cg10426581 chr7:100472382 SRRT 0.82 7.99 0.44 4.27e-14 Resting heart rate; CESC cis rs1691799 0.899 rs1168317 chr12:66746225 C/T cg16791601 chr12:66731901 HELB -0.8 -14.72 -0.67 2.96e-36 White blood cell count (basophil); CESC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg14703610 chr5:56206110 C5orf35 -0.41 -5.08 -0.3 7.23e-7 Initial pursuit acceleration; CESC cis rs7914558 1.000 rs67908413 chr10:104764989 T/C cg08650961 chr10:104748594 CNNM2 0.33 5.47 0.32 1.03e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25341937 chr6:17706893 NUP153 0.65 7.64 0.42 4.03e-13 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27632268 chr1:221915475 DUSP10 -0.6 -6.7 -0.38 1.23e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05273006 chr15:62534197 NA -0.56 -7.25 -0.41 4.44e-12 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23850707 chr15:55582494 RAB27A -0.44 -6.19 -0.36 2.22e-9 Fibrinogen levels; CESC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg10053473 chr17:62856997 LRRC37A3 -0.57 -6.78 -0.38 7.66e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg23590916 chr17:43697445 MGC57346 -0.61 -6.5 -0.37 3.94e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2985684 0.625 rs4900931 chr14:50022793 A/T cg02151108 chr14:50098012 C14orf104 -0.4 -5.38 -0.31 1.62e-7 Carotid intima media thickness; CESC cis rs826838 0.967 rs1486345 chr12:39131677 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.27 -0.36 1.48e-9 Heart rate; CESC cis rs9611565 0.512 rs139572 chr22:42214532 C/T cg17376030 chr22:41985996 PMM1 0.78 8.09 0.45 2.12e-14 Vitiligo; CESC cis rs9457247 0.765 rs3752520 chr6:167436159 T/C cg23791538 chr6:167370224 RNASET2 -0.55 -7.51 -0.42 8.97e-13 Crohn's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08990514 chr17:48672483 CACNA1G -0.41 -6.18 -0.35 2.4e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20743544 chr7:32982957 RP9P 0.47 6.03 0.35 5.6e-9 Gut microbiota (bacterial taxa); CESC cis rs6088590 0.965 rs6120730 chr20:33385102 G/C cg24642439 chr20:33292090 TP53INP2 0.85 11.66 0.58 1.22e-25 Coronary artery disease; CESC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs1215050 0.765 rs588851 chr4:98678247 C/T cg05340658 chr4:99064831 C4orf37 0.47 6.04 0.35 5.08e-9 Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06264303 chr10:38299291 ZNF33A -0.59 -6.55 -0.37 3e-10 Gut microbiome composition (summer); CESC cis rs6546550 0.835 rs3755389 chr2:70119469 T/C cg02498382 chr2:70120550 SNRNP27 -0.42 -7.49 -0.42 1.04e-12 Prevalent atrial fibrillation; CESC cis rs7259376 0.807 rs6511348 chr19:22557374 G/A cg02657401 chr19:22469223 NA -0.26 -5.17 -0.3 4.7e-7 Menopause (age at onset); CESC cis rs11676348 0.846 rs3890158 chr2:218990292 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.16 -0.35 2.74e-9 Ulcerative colitis; CESC cis rs8092503 1.000 rs8089801 chr18:52479764 G/A cg12377874 chr18:52495404 RAB27B 0.38 6.27 0.36 1.46e-9 Childhood body mass index; CESC cis rs933688 1.000 rs933688 chr5:90762748 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.83 10.71 0.55 1.74e-22 Smoking behavior; CESC cis rs3857536 0.605 rs36040831 chr6:66876588 G/A cg07460842 chr6:66804631 NA -0.72 -10.39 -0.54 1.98e-21 Blood trace element (Cu levels); CESC cis rs4853525 0.522 rs7574840 chr2:191584236 C/G cg10560079 chr2:191398806 TMEM194B -0.44 -5.51 -0.32 8.34e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; CESC cis rs7703051 0.901 rs4704220 chr5:74757556 G/A cg03227963 chr5:74354835 NA 0.29 5.33 0.31 2.13e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs6674176 0.660 rs6680421 chr1:44408969 A/C cg23954153 chr1:44402353 ARTN 0.34 5.26 0.31 2.95e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs660899 0.894 rs6429637 chr1:44198531 A/G cg19743044 chr1:44115203 KDM4A 0.44 5.25 0.31 3.16e-7 Hypertension risk in short sleep duration; CESC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg08470875 chr2:26401718 FAM59B -0.47 -5.24 -0.31 3.31e-7 Gut microbiome composition (summer); CESC cis rs3026101 0.671 rs56061343 chr17:5318502 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.22 0.31 3.64e-7 Body mass index; CESC cis rs7917772 0.536 rs3961456 chr10:104425304 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.57 -7.4 -0.41 1.8e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg06766960 chr11:133703094 NA -0.39 -5.61 -0.33 4.96e-8 Childhood ear infection; CESC cis rs7216064 1.000 rs7223813 chr17:65945840 A/G cg07042672 chr17:66097459 LOC651250 -0.54 -5.86 -0.34 1.37e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg27572855 chr1:25598939 RHD 0.5 8.55 0.46 9.98e-16 Erythrocyte sedimentation rate; CESC cis rs4604732 0.574 rs111928142 chr1:247625229 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.39 0.37 7.32e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs637571 0.615 rs10160792 chr11:65667149 C/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.59 7.39 0.41 1.97e-12 Eosinophil percentage of white cells; CESC trans rs7618501 0.633 rs2526748 chr3:50080439 A/G cg21659725 chr3:3221576 CRBN -0.49 -6.88 -0.39 4.2e-11 Intelligence (multi-trait analysis); CESC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg24531977 chr5:56204891 C5orf35 -0.88 -11.52 -0.58 3.54e-25 Initial pursuit acceleration; CESC cis rs11825685 0.775 rs115695236 chr11:134569427 A/T cg06603561 chr11:134479413 NA -0.66 -5.68 -0.33 3.45e-8 IgG glycosylation; CESC cis rs9905704 0.756 rs389389 chr17:56676368 A/G cg12560992 chr17:57184187 TRIM37 0.58 5.51 0.32 8.4e-8 Testicular germ cell tumor; CESC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg13147721 chr7:65941812 NA 0.41 5.57 0.32 6.39e-8 Aortic root size; CESC cis rs7937 0.693 rs17726276 chr19:41291119 A/G cg09274963 chr19:41633902 CYP2F1 0.36 5.44 0.32 1.23e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Chronic obstructive pulmonary disease;Emphysema imaging phenotypes; CESC cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg25174290 chr11:3078921 CARS 0.56 7.47 0.42 1.16e-12 Longevity; CESC cis rs8044868 0.530 rs2288002 chr16:72057282 A/G cg16558253 chr16:72132732 DHX38 -0.36 -5.48 -0.32 1.01e-7 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC trans rs941207 0.514 rs6581105 chr12:57185968 T/C cg26462586 chr2:11164677 NA 0.39 6.17 0.35 2.59e-9 Platelet count; CESC cis rs2295359 0.892 rs56920441 chr1:67652012 A/G cg17031739 chr1:67600172 NA 0.39 5.3 0.31 2.4e-7 Psoriasis; CESC cis rs1023500 0.505 rs134889 chr22:42674350 A/T cg04733989 chr22:42467013 NAGA 0.65 9.83 0.52 1.18e-19 Schizophrenia; CESC cis rs11098499 0.820 rs28578366 chr4:120536905 A/G cg09307838 chr4:120376055 NA -0.87 -11.88 -0.59 2.2e-26 Corneal astigmatism; CESC cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg05340658 chr4:99064831 C4orf37 0.84 12.91 0.62 6.47e-30 Colonoscopy-negative controls vs population controls; CESC cis rs748404 0.723 rs11853991 chr15:43557549 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.39 5.08 0.3 7.01e-7 Lung cancer; CESC cis rs3806843 1.000 rs13184940 chr5:140172918 T/C cg26395211 chr5:140044315 WDR55 -0.41 -5.26 -0.31 2.97e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg09359103 chr1:154839909 KCNN3 -0.65 -12.4 -0.61 3.83e-28 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01947930 chr5:141016379 RELL2;HDAC3 0.53 6.09 0.35 4.04e-9 Gut microbiome composition (summer); CESC cis rs3026101 0.671 rs2871203 chr17:5298490 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs1707322 0.785 rs10890348 chr1:46242423 G/T cg06784218 chr1:46089804 CCDC17 0.37 6.33 0.36 1.02e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1879734 0.689 rs11206201 chr1:54170963 C/A cg23596471 chr1:54105337 GLIS1 0.35 5.58 0.32 5.97e-8 Mitral valve prolapse; CESC cis rs6964587 0.872 rs57969083 chr7:91665627 A/T cg17063962 chr7:91808500 NA 0.56 7.79 0.43 1.54e-13 Breast cancer; CESC cis rs698833 0.758 rs7586188 chr2:44544955 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.84 0.34 1.56e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs643506 1.000 rs647080 chr11:111609174 A/G cg09085632 chr11:111637200 PPP2R1B 0.54 7.0 0.39 2.11e-11 Breast cancer; CESC cis rs1348850 0.645 rs11887886 chr2:178425730 C/T cg22681709 chr2:178499509 PDE11A -0.53 -6.64 -0.38 1.72e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6502050 0.835 rs8077772 chr17:80117220 A/G cg23985595 chr17:80112537 CCDC57 0.37 5.76 0.33 2.36e-8 Life satisfaction; CESC cis rs9303280 0.901 rs1008723 chr17:38066267 G/T cg20243544 chr17:37824526 PNMT 0.52 6.85 0.39 5.09e-11 Self-reported allergy; CESC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.57 7.09 0.4 1.19e-11 Prudent dietary pattern; CESC cis rs9303401 0.659 rs714959 chr17:56628601 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.0 12.72 0.62 2.99e-29 Cognitive test performance; CESC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg15369054 chr17:80825471 TBCD -0.39 -5.59 -0.32 5.76e-8 Breast cancer; CESC cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg23281280 chr6:28129359 ZNF389 0.6 8.0 0.44 3.86e-14 Depression; CESC cis rs738322 0.967 rs132985 chr22:38563471 C/T cg25457927 chr22:38595422 NA -0.3 -5.72 -0.33 2.87e-8 Cutaneous nevi; CESC cis rs6499255 1.000 rs11075734 chr16:69801397 G/T cg15192750 chr16:69999425 NA 0.47 5.79 0.34 1.94e-8 IgE levels; CESC cis rs3733418 0.860 rs13142064 chr4:165943549 G/A cg10852876 chr4:165953100 TRIM60 -0.49 -5.87 -0.34 1.29e-8 Obesity-related traits; CESC cis rs9486719 0.948 rs11152970 chr6:96909077 A/G cg18709589 chr6:96969512 KIAA0776 -0.56 -6.11 -0.35 3.51e-9 Migraine;Coronary artery disease; CESC cis rs2288073 0.965 rs10173949 chr2:24410256 A/C cg06627628 chr2:24431161 ITSN2 -0.73 -8.64 -0.47 5.5e-16 Venous thromboembolism (SNP x SNP interaction); CESC cis rs11098499 0.954 rs11722872 chr4:120233030 G/C cg24375607 chr4:120327624 NA 0.46 5.57 0.32 6.18e-8 Corneal astigmatism; CESC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg07090678 chr1:91966139 CDC7 0.41 5.63 0.33 4.52e-8 Breast cancer; CESC cis rs870825 0.616 rs6843185 chr4:185649878 A/C cg04058563 chr4:185651563 MLF1IP 0.65 7.2 0.4 6.19e-12 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09551172 chr1:100315427 AGL 0.58 6.79 0.38 7.52e-11 Gut microbiome composition (summer); CESC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg09323728 chr8:95962352 TP53INP1 -0.39 -8.59 -0.47 7.58e-16 Type 2 diabetes; CESC cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg12641515 chr19:46296257 DMWD 0.73 9.62 0.51 5.43e-19 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00624332 chr10:103880351 LDB1 0.54 6.06 0.35 4.78e-9 Gut microbiome composition (summer); CESC cis rs9309473 1.000 rs6711033 chr2:73746643 T/C cg20560298 chr2:73613845 ALMS1 -0.47 -6.47 -0.37 4.73e-10 Metabolite levels; CESC cis rs12586317 0.511 rs75552348 chr14:35385747 G/A cg16230307 chr14:35515116 FAM177A1 1.07 10.65 0.55 2.72e-22 Psoriasis; CESC cis rs7336332 0.598 rs7669 chr13:28009851 C/T cg01674679 chr13:27998804 GTF3A -0.63 -5.95 -0.34 8.23e-9 Weight; CESC cis rs2637266 0.703 rs846620 chr10:78545387 G/A cg18941641 chr10:78392320 NA 0.4 7.64 0.42 3.93e-13 Pulmonary function; CESC cis rs9902453 0.935 rs9911794 chr17:28349466 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.83 -0.43 1.15e-13 Coffee consumption (cups per day); CESC cis rs4746818 1.000 rs7916991 chr10:70895373 C/A cg04149295 chr10:70884716 VPS26A 0.56 5.03 0.3 8.94e-7 Left atrial antero-posterior diameter; CESC cis rs6831352 0.918 rs7694646 chr4:100059732 T/A cg13256891 chr4:100009986 ADH5 -0.75 -8.21 -0.45 9.89e-15 Alcohol dependence; CESC cis rs4474465 0.646 rs7937417 chr11:78284470 A/G cg01578073 chr11:78285783 NARS2 -0.44 -5.12 -0.3 5.99e-7 Alzheimer's disease (survival time); CESC cis rs712039 0.583 rs853223 chr17:35791149 T/C cg16670864 chr17:35848621 DUSP14 0.41 5.13 0.3 5.52e-7 Tuberculosis; CESC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg07507251 chr3:52567010 NT5DC2 0.34 5.73 0.33 2.7e-8 Bipolar disorder; CESC cis rs4843747 0.573 rs7499959 chr16:88110422 C/G cg17633681 chr16:88106987 BANP 0.55 7.08 0.4 1.27e-11 Menopause (age at onset); CESC trans rs637571 0.522 rs556643 chr11:65733289 C/T cg17712092 chr4:129076599 LARP1B 0.69 9.36 0.5 3.63e-18 Eosinophil percentage of white cells; CESC cis rs734999 0.545 rs4074789 chr1:2537464 A/G cg18854424 chr1:2615690 NA 0.3 6.15 0.35 2.81e-9 Ulcerative colitis; CESC cis rs870825 0.616 rs14969 chr4:185615764 C/A cg04058563 chr4:185651563 MLF1IP 0.65 7.14 0.4 9.11e-12 Blood protein levels; CESC cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.29 0.45 5.87e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs769267 0.501 rs2965187 chr19:19522970 T/A cg20644253 chr19:19431407 KIAA0892;SF4 0.5 5.38 0.31 1.68e-7 Tonsillectomy; CESC cis rs77216612 0.840 rs11055030 chr12:12878349 G/C cg04607235 chr12:12878440 APOLD1 -1.05 -16.31 -0.71 6.68e-42 Lymphocyte counts; CESC cis rs9916302 0.904 rs10852933 chr17:37698194 G/T cg15445000 chr17:37608096 MED1 0.42 6.91 0.39 3.53e-11 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16424138 chr5:14581771 FAM105A 0.53 6.19 0.36 2.32e-9 Gut microbiome composition (summer); CESC cis rs4129585 0.928 rs13262595 chr8:143316970 A/G cg16886403 chr8:143471632 TSNARE1 0.43 5.28 0.31 2.76e-7 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs9815354 0.904 rs73079327 chr3:41864697 A/T cg03022575 chr3:42003672 ULK4 0.46 5.29 0.31 2.57e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs2295499 0.873 rs4690085 chr4:2697300 A/G cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.42 -0.32 1.34e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg18252515 chr7:66147081 NA 0.47 6.08 0.35 4.25e-9 Aortic root size; CESC trans rs875971 0.558 rs4433015 chr7:65639723 A/C cg26939375 chr7:64535504 NA -0.6 -8.07 -0.44 2.5e-14 Aortic root size; CESC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 9.81 0.52 1.38e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg26335602 chr6:28129616 ZNF389 0.45 5.75 0.33 2.5e-8 Parkinson's disease; CESC cis rs1009170 0.794 rs9919953 chr14:92582974 C/A cg10324096 chr14:92587714 CPSF2;NDUFB1 0.55 5.11 0.3 6.15e-7 Dialysis-related mortality; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03041730 chr4:903314 GAK 0.56 7.42 0.41 1.55e-12 Fibrinogen levels; CESC trans rs2207136 0.835 rs10948579 chr6:50871405 G/A cg06522515 chr3:184090630 THPO -0.36 -6.24 -0.36 1.69e-9 Myopia; CESC cis rs13191362 1.000 rs34619021 chr6:163029767 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.81 8.44 0.46 2.13e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg12311346 chr5:56204834 C5orf35 0.87 10.78 0.55 1.05e-22 Initial pursuit acceleration; CESC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg00149659 chr3:10157352 C3orf10 0.73 8.81 0.48 1.65e-16 Alzheimer's disease; CESC cis rs4654899 0.965 rs4654907 chr1:21521094 C/T cg05370193 chr1:21551575 ECE1 0.41 6.25 0.36 1.62e-9 Superior frontal gyrus grey matter volume; CESC cis rs1371867 0.726 rs1660333 chr8:101309989 A/G cg11906718 chr8:101322791 RNF19A 0.51 6.75 0.38 9.5e-11 Atrioventricular conduction; CESC cis rs10751667 0.714 rs7933889 chr11:972270 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.49e-7 Alzheimer's disease (late onset); CESC cis rs4790333 0.539 rs67887169 chr17:2256828 G/A cg02569219 chr17:2266849 SGSM2 0.39 5.14 0.3 5.3e-7 Proinsulin levels; CESC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg16049864 chr8:95962084 TP53INP1 0.64 11.34 0.57 1.5e-24 Type 2 diabetes; CESC cis rs9905704 0.918 rs9891129 chr17:56630474 T/C cg12560992 chr17:57184187 TRIM37 -0.61 -7.02 -0.4 1.8e-11 Testicular germ cell tumor; CESC trans rs7824557 0.564 rs2736301 chr8:11236413 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -6.15 -0.35 2.9e-9 Retinal vascular caliber; CESC cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg26874164 chr19:58962979 ZNF324B 0.54 7.41 0.41 1.73e-12 Uric acid clearance; CESC cis rs72634258 0.836 rs7545687 chr1:7997183 G/A cg00042356 chr1:8021962 PARK7 0.9 8.11 0.45 1.9e-14 Inflammatory bowel disease; CESC cis rs9398803 0.965 rs2027299 chr6:126685827 G/C cg19875578 chr6:126661172 C6orf173 0.48 6.73 0.38 1.06e-10 Male-pattern baldness; CESC cis rs7264396 0.635 rs6060675 chr20:34493614 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.58 7.05 0.4 1.57e-11 Total cholesterol levels; CESC trans rs6601327 0.775 rs12156017 chr8:9406837 C/G cg15556689 chr8:8085844 FLJ10661 -0.52 -6.42 -0.37 6.2e-10 Multiple myeloma (hyperdiploidy); CESC trans rs35110281 0.743 rs2329443 chr21:45059431 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 6.76 0.38 8.53e-11 Mean corpuscular volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01936430 chr1:204380496 PPP1R15B -0.5 -6.57 -0.37 2.69e-10 Ulcerative colitis; CESC cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg02079420 chr8:82753780 SNX16 -0.58 -7.73 -0.43 2.18e-13 Diastolic blood pressure; CESC cis rs7726839 0.526 rs55647623 chr5:567747 T/C cg16447950 chr5:562315 NA -0.63 -7.22 -0.41 5.35e-12 Obesity-related traits; CESC cis rs67460515 0.563 rs7618924 chr3:160855599 A/G cg03342759 chr3:160939853 NMD3 -0.55 -7.33 -0.41 2.7e-12 Parkinson's disease; CESC cis rs78889164 0.956 rs16968029 chr19:33869175 C/T cg02272751 chr19:33882848 PEPD -0.52 -6.88 -0.39 4.24e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs11190604 0.943 rs11190588 chr10:102273565 C/T cg07080220 chr10:102295463 HIF1AN 0.66 5.98 0.34 7.36e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs12530845 0.887 rs61360007 chr7:135316879 G/A cg23117316 chr7:135346802 PL-5283 -0.48 -5.83 -0.34 1.58e-8 Red blood cell traits; CESC cis rs9399135 0.904 rs4895438 chr6:135317665 G/T cg24558204 chr6:135376177 HBS1L 0.53 7.2 0.4 6.1e-12 Red blood cell count; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07541443 chr13:114260546 TFDP1 -0.49 -6.39 -0.37 7.35e-10 Systemic lupus erythematosus; CESC cis rs10504073 0.647 rs12546839 chr8:50009020 C/T cg00325661 chr8:49890786 NA 0.57 8.45 0.46 1.97e-15 Blood metabolite ratios; CESC cis rs7267979 1.000 rs1077889 chr20:25267893 A/G cg08601574 chr20:25228251 PYGB 0.4 5.77 0.33 2.2e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2797160 0.714 rs1777220 chr6:126022602 G/T cg05901451 chr6:126070800 HEY2 0.49 7.05 0.4 1.59e-11 Endometrial cancer; CESC cis rs1448094 0.511 rs17279338 chr12:86162874 G/A cg02569458 chr12:86230093 RASSF9 0.49 7.62 0.42 4.61e-13 Major depressive disorder; CESC cis rs853679 0.599 rs149943 chr6:28002388 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.8 6.55 0.37 2.92e-10 Depression; CESC cis rs9858542 1.000 rs9823546 chr3:49705512 T/A cg03060546 chr3:49711283 APEH -0.57 -6.79 -0.38 7.39e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs17818399 0.547 rs4953400 chr2:46777208 T/A cg02822958 chr2:46747628 ATP6V1E2 0.42 5.26 0.31 2.96e-7 Height; CESC cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg05347473 chr6:146136440 FBXO30 0.72 9.11 0.49 2.04e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs7592578 0.882 rs2192010 chr2:191462133 C/T cg10560079 chr2:191398806 TMEM194B -0.67 -5.81 -0.34 1.76e-8 Diastolic blood pressure; CESC cis rs3008870 1.000 rs3008870 chr1:67418027 C/T cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg16743903 chr16:89593216 SPG7 -0.47 -6.11 -0.35 3.5e-9 Multiple myeloma (IgH translocation); CESC cis rs1552244 0.554 rs7638846 chr3:10048601 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.64 8.26 0.45 6.96e-15 Alzheimer's disease; CESC cis rs4253772 0.530 rs9627387 chr22:46684678 A/G cg09491104 chr22:46646882 C22orf40 -0.57 -8.52 -0.46 1.21e-15 LDL cholesterol;Cholesterol, total; CESC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.69 -0.38 1.3e-10 Bipolar disorder; CESC cis rs12579753 0.917 rs10862375 chr12:82254809 C/G cg23701643 chr12:82153290 PPFIA2 0.35 5.11 0.3 6.11e-7 Resting heart rate; CESC cis rs6570726 0.846 rs7773939 chr6:145927384 C/T cg05347473 chr6:146136440 FBXO30 -0.47 -6.12 -0.35 3.44e-9 Lobe attachment (rater-scored or self-reported); CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg07332563 chr6:291687 DUSP22 0.67 8.75 0.47 2.6e-16 Menopause (age at onset); CESC cis rs9486719 0.947 rs11755945 chr6:96908038 G/C cg18709589 chr6:96969512 KIAA0776 -0.56 -6.11 -0.35 3.51e-9 Migraine;Coronary artery disease; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg07204069 chr17:72772514 TMEM104;NAT9 0.46 6.23 0.36 1.83e-9 Bronchopulmonary dysplasia; CESC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg06108461 chr20:60628389 TAF4 -0.93 -14.52 -0.67 1.46e-35 Body mass index; CESC cis rs4073582 0.595 rs708471 chr11:65931008 A/G cg14036092 chr11:66035641 RAB1B 0.54 7.53 0.42 7.89e-13 Gout; CESC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.02 16.64 0.71 4.66e-43 Height; CESC cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg08392591 chr16:89556376 ANKRD11 -0.4 -5.19 -0.3 4.22e-7 Multiple myeloma (IgH translocation); CESC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg10560079 chr2:191398806 TMEM194B 0.49 6.85 0.39 5.15e-11 Pulse pressure; CESC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg14829155 chr15:31115871 NA -0.72 -9.72 -0.51 2.73e-19 Huntington's disease progression; CESC cis rs6088580 0.542 rs6059882 chr20:33090167 T/C cg06115741 chr20:33292138 TP53INP2 0.44 5.59 0.32 5.74e-8 Glomerular filtration rate (creatinine); CESC cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg01475377 chr6:109611718 NA -0.42 -6.43 -0.37 6.01e-10 Reticulocyte fraction of red cells; CESC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.59 0.64 2.72e-32 Prudent dietary pattern; CESC cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg03060546 chr3:49711283 APEH 0.53 6.51 0.37 3.65e-10 Parkinson's disease; CESC cis rs7107174 1.000 rs10793303 chr11:78060750 G/A cg02023728 chr11:77925099 USP35 0.47 6.25 0.36 1.63e-9 Testicular germ cell tumor; CESC cis rs3015497 0.603 rs955879 chr14:51081974 G/A cg26011998 chr14:51135199 SAV1 -0.45 -5.21 -0.3 3.84e-7 Mean platelet volume; CESC trans rs12310956 0.532 rs10844712 chr12:33961022 G/A cg26384229 chr12:38710491 ALG10B 0.52 7.15 0.4 8.38e-12 Morning vs. evening chronotype; CESC cis rs17253792 0.822 rs13379353 chr14:56050478 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.86 0.34 1.36e-8 Putamen volume; CESC trans rs7618501 0.966 rs9882639 chr3:49799475 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.5 0.46 1.36e-15 Intelligence (multi-trait analysis); CESC cis rs6142102 0.625 rs1883706 chr20:32552877 G/A cg08999081 chr20:33150536 PIGU 0.34 5.1 0.3 6.63e-7 Skin pigmentation; CESC cis rs116095464 0.558 rs7708182 chr5:234788 C/G cg22857025 chr5:266934 NA -1.29 -18.85 -0.76 7.33e-51 Breast cancer; CESC cis rs67311347 1.000 rs9849992 chr3:40402140 C/T cg09455208 chr3:40491958 NA 0.52 8.94 0.48 6.71e-17 Renal cell carcinoma; CESC cis rs10927875 0.619 rs2102664 chr1:16130169 A/G cg21385522 chr1:16154831 NA -0.76 -10.68 -0.55 2.15e-22 Dilated cardiomyopathy; CESC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg17143192 chr8:8559678 CLDN23 0.75 8.46 0.46 1.78e-15 Obesity-related traits; CESC cis rs300703 0.935 rs300704 chr2:240255 A/C cg21211680 chr2:198530 NA 0.97 7.77 0.43 1.68e-13 Blood protein levels; CESC cis rs67478160 0.625 rs7141473 chr14:104316055 A/C cg08213375 chr14:104286397 PPP1R13B -0.54 -10.49 -0.54 9.46e-22 Schizophrenia; CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg10819733 chr22:24237672 NA -0.42 -5.92 -0.34 9.84e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7178572 0.568 rs4243045 chr15:77455914 A/C cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC cis rs12477438 0.520 rs11678456 chr2:99708237 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.92 15.86 0.7 2.85e-40 Chronic sinus infection; CESC cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg23158103 chr7:148848205 ZNF398 -0.39 -5.99 -0.35 6.83e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs921968 0.608 rs495855 chr2:219357858 A/G cg02176678 chr2:219576539 TTLL4 0.39 6.69 0.38 1.32e-10 Mean corpuscular hemoglobin concentration; CESC cis rs4664308 0.905 rs7567781 chr2:160999537 A/G cg03641300 chr2:160917029 PLA2R1 -0.65 -9.52 -0.5 1.1e-18 Idiopathic membranous nephropathy; CESC cis rs3126085 0.935 rs4845734 chr1:152167473 T/C cg03465714 chr1:152285911 FLG -0.47 -5.73 -0.33 2.74e-8 Atopic dermatitis; CESC cis rs9287719 0.934 rs6432111 chr2:10744620 A/C cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs9309473 1.000 rs13432605 chr2:73810981 C/G cg20560298 chr2:73613845 ALMS1 -0.53 -6.93 -0.39 3.24e-11 Metabolite levels; CESC cis rs1864400 0.690 rs7098237 chr10:43740513 T/A cg15436174 chr10:43711423 RASGEF1A 0.46 5.3 0.31 2.44e-7 Hirschsprung disease; CESC cis rs2531992 0.925 rs2531993 chr16:4014245 A/G cg05927578 chr16:4029543 ADCY9 0.45 5.64 0.33 4.37e-8 Waist circumference; CESC cis rs2882667 0.964 rs2288824 chr5:138298396 C/T cg04439458 chr5:138467593 SIL1 -0.37 -5.75 -0.33 2.51e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg16405210 chr4:1374714 KIAA1530 0.76 10.52 0.54 7.19e-22 Obesity-related traits; CESC cis rs476633 0.691 rs6492997 chr15:41541171 G/A cg12386646 chr15:41787261 ITPKA 0.36 5.36 0.31 1.78e-7 Glomerular filtration rate (creatinine); CESC cis rs2115536 0.967 rs934137 chr15:80211768 T/C cg11839771 chr15:80205821 ST20 -0.37 -5.38 -0.31 1.62e-7 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC trans rs61931739 0.534 rs1352207 chr12:34036862 C/T cg26384229 chr12:38710491 ALG10B -0.5 -6.9 -0.39 3.85e-11 Morning vs. evening chronotype; CESC cis rs7100689 0.577 rs10749551 chr10:82054001 A/C cg09936400 chr10:82049201 MAT1A 0.39 5.93 0.34 9.23e-9 Post bronchodilator FEV1; CESC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg17747265 chr1:1875780 NA -0.56 -9.17 -0.49 1.39e-17 Body mass index; CESC cis rs9487051 0.639 rs2884012 chr6:109598221 C/T cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg19193384 chr17:30244184 NA -0.72 -6.84 -0.39 5.61e-11 Hip circumference adjusted for BMI; CESC cis rs1218582 0.661 rs4845695 chr1:154911798 A/G cg16680214 chr1:154839983 KCNN3 -0.46 -6.84 -0.39 5.44e-11 Prostate cancer; CESC cis rs6460942 1.000 rs7792759 chr7:12311715 A/G cg06484146 chr7:12443880 VWDE 0.66 7.22 0.41 5.52e-12 Coronary artery disease; CESC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg06484146 chr7:12443880 VWDE -0.74 -8.94 -0.48 6.6e-17 Coronary artery disease; CESC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg16145915 chr7:1198662 ZFAND2A -0.5 -6.34 -0.36 9.61e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.29 -0.31 2.58e-7 Gut microbiome composition (summer); CESC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg17376030 chr22:41985996 PMM1 0.55 6.19 0.36 2.23e-9 Vitiligo; CESC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg25838465 chr1:92012736 NA -0.61 -8.91 -0.48 8.65e-17 Breast cancer; CESC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg02034447 chr16:89574710 SPG7 0.54 7.08 0.4 1.32e-11 Multiple myeloma (IgH translocation); CESC cis rs12824058 0.831 rs11608406 chr12:130805866 G/C cg26677194 chr12:130822605 PIWIL1 0.48 6.19 0.36 2.3e-9 Menopause (age at onset); CESC cis rs9300255 0.602 rs1727315 chr12:123638930 A/G cg00376283 chr12:123451042 ABCB9 -0.71 -8.85 -0.48 1.27e-16 Neutrophil percentage of white cells; CESC cis rs2075371 0.796 rs1646644 chr7:134011817 A/T cg11752832 chr7:134001865 SLC35B4 0.49 6.1 0.35 3.68e-9 Mean platelet volume; CESC cis rs6088580 0.634 rs1205344 chr20:32918298 G/A cg06115741 chr20:33292138 TP53INP2 -0.45 -5.67 -0.33 3.66e-8 Glomerular filtration rate (creatinine); CESC cis rs2204008 0.774 rs10400552 chr12:38393577 C/G cg26384229 chr12:38710491 ALG10B 0.71 10.57 0.54 5.24e-22 Bladder cancer; CESC cis rs3916 0.662 rs2138249 chr12:121124142 A/C cg20569203 chr12:120799911 MSI1 0.29 5.09 0.3 6.9e-7 Urinary metabolites (H-NMR features); CESC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg17949981 chr6:28129498 ZNF389 0.44 5.58 0.32 5.97e-8 Parkinson's disease; CESC cis rs10736390 0.640 rs10888858 chr1:55108978 A/G cg01517571 chr1:55089959 ACOT11;FAM151A -0.57 -7.73 -0.43 2.29e-13 Survival in pancreatic cancer; CESC cis rs9916302 0.861 rs4795376 chr17:37669043 T/C cg00129232 chr17:37814104 STARD3 -0.56 -7.49 -0.42 1e-12 Glomerular filtration rate (creatinine); CESC cis rs7772486 0.692 rs2265915 chr6:146194332 A/T cg05347473 chr6:146136440 FBXO30 0.6 7.7 0.43 2.66e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg17971929 chr21:40555470 PSMG1 -0.6 -7.86 -0.43 9.65e-14 Menarche (age at onset); CESC cis rs10242455 0.571 rs6955162 chr7:99184400 T/G cg25640893 chr7:99214727 ZNF498 1.16 7.57 0.42 6.25e-13 Blood metabolite levels; CESC cis rs2228479 0.850 rs17233455 chr16:89816407 A/G cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -12.15 -0.6 2.74e-27 Alzheimer's disease; CESC cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg23158103 chr7:148848205 ZNF398 0.41 6.55 0.37 2.94e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs6951245 0.554 rs11544331 chr7:1131411 C/T cg13565492 chr6:43139072 SRF -0.72 -8.44 -0.46 2.12e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4819052 0.851 rs2255774 chr21:46683851 A/T cg11663144 chr21:46675770 NA -0.43 -6.9 -0.39 3.76e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12824058 0.831 rs12831363 chr12:130814013 C/T cg26677194 chr12:130822605 PIWIL1 -0.52 -6.86 -0.39 4.77e-11 Menopause (age at onset); CESC cis rs644799 1.000 rs474252 chr11:95619292 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.61 7.66 0.43 3.46e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2841233 0.692 rs2028416 chr14:105348552 C/T cg16576083 chr14:105354267 KIAA0284 0.48 7.69 0.43 2.9e-13 IgG glycosylation; CESC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.7 -8.01 -0.44 3.69e-14 Gut microbiome composition (summer); CESC cis rs10845606 1.000 rs10845606 chr12:12834894 G/T cg09462578 chr12:12878428 APOLD1 -0.63 -6.92 -0.39 3.4e-11 Systemic lupus erythematosus; CESC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg13798912 chr7:905769 UNC84A 0.56 5.7 0.33 3.11e-8 Cerebrospinal P-tau181p levels; CESC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs12956009 0.583 rs12327454 chr18:44863964 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.45 0.37 5.28e-10 Educational attainment (years of education); CESC cis rs9583531 0.600 rs6492305 chr13:111361400 C/T cg24331049 chr13:111365604 ING1 0.75 10.98 0.56 2.28e-23 Coronary artery disease; CESC cis rs146201400 1 rs146201400 chr1:26645955 G/GA cg00852783 chr1:26633632 UBXN11 0.5 7.0 0.39 2.16e-11 Monocyte percentage of white cells; CESC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.47 -0.37 4.81e-10 Life satisfaction; CESC cis rs3782089 1.000 rs3782089 chr11:65336819 C/T cg21890820 chr11:65308645 LTBP3 0.96 7.81 0.43 1.33e-13 Height; CESC cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg00701064 chr4:6280414 WFS1 0.75 13.59 0.64 2.91e-32 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs763014 0.898 rs8060585 chr16:635794 C/G cg07343612 chr16:622815 PIGQ -0.55 -7.99 -0.44 4.25e-14 Height; CESC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg18337363 chr3:52569053 NT5DC2 0.29 5.3 0.31 2.43e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.12 0.3 5.96e-7 Colonoscopy-negative controls vs population controls; CESC cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg26597838 chr10:835615 NA 0.87 9.16 0.49 1.48e-17 Eosinophil percentage of granulocytes; CESC cis rs921968 0.548 rs13427522 chr2:219438359 C/T cg02176678 chr2:219576539 TTLL4 0.41 7.15 0.4 8.68e-12 Mean corpuscular hemoglobin concentration; CESC cis rs2635047 0.638 rs12968552 chr18:44702502 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.68 0.33 3.46e-8 Educational attainment; CESC cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.54e-10 Blood protein levels; CESC trans rs11098499 0.863 rs3822192 chr4:120445720 A/C cg25214090 chr10:38739885 LOC399744 0.7 9.46 0.5 1.75e-18 Corneal astigmatism; CESC cis rs3096299 0.967 rs2965937 chr16:89488779 A/T cg08822215 chr16:89438651 ANKRD11 -0.38 -5.86 -0.34 1.38e-8 Multiple myeloma (IgH translocation); CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg24799514 chr20:44420531 WFDC3;DNTTIP1 0.47 6.18 0.35 2.36e-9 Post-traumatic stress disorder; CESC trans rs9354308 0.866 rs2802054 chr6:66544766 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 6.62 0.38 1.93e-10 Metabolite levels; CESC cis rs3096299 0.866 rs4238829 chr16:89462262 G/A cg08822215 chr16:89438651 ANKRD11 -0.46 -7.15 -0.4 8.58e-12 Multiple myeloma (IgH translocation); CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 7.53 0.42 7.77e-13 Bipolar disorder; CESC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg18876405 chr7:65276391 NA 0.52 6.87 0.39 4.64e-11 Aortic root size; CESC cis rs9926296 0.572 rs8046872 chr16:89841552 T/C cg27121462 chr16:89883253 FANCA 0.55 6.88 0.39 4.18e-11 Vitiligo; CESC cis rs8060686 0.641 rs55790290 chr16:68180242 A/G cg26727032 chr16:67993705 SLC12A4 -0.53 -6.02 -0.35 5.67e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs10518765 0.945 rs17237564 chr15:54660722 C/T cg09098624 chr8:11558334 NA 0.55 6.04 0.35 5.11e-9 Select biomarker traits; CESC cis rs854765 0.647 rs854814 chr17:18003648 G/A cg16928487 chr17:17741425 SREBF1 -0.52 -8.39 -0.46 2.92e-15 Total body bone mineral density; CESC cis rs6540556 0.723 rs6702301 chr1:209923154 C/T cg05527609 chr1:210001259 C1orf107 -0.51 -6.21 -0.36 2.08e-9 Red blood cell count; CESC cis rs2710642 0.564 rs7558681 chr2:62840987 G/A cg17519650 chr2:63277830 OTX1 0.48 6.42 0.37 6.39e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs9987353 0.519 rs11779181 chr8:9063027 A/G cg06636001 chr8:8085503 FLJ10661 0.51 6.21 0.36 2.07e-9 Recombination measurement; CESC cis rs3820068 0.581 rs59684759 chr1:15919893 A/G cg16988262 chr1:15930761 NA 0.35 5.59 0.32 5.74e-8 Systolic blood pressure; CESC cis rs3936840 0.539 rs3742445 chr14:102975552 T/A cg18135206 chr14:102964638 TECPR2 0.46 5.83 0.34 1.57e-8 Plateletcrit; CESC cis rs17818399 0.716 rs62134741 chr2:46782189 G/A cg02822958 chr2:46747628 ATP6V1E2 0.45 5.29 0.31 2.55e-7 Height; CESC cis rs58785573 0.504 rs3860067 chr4:38611905 T/C cg18361445 chr4:38666374 KLF3;FLJ13197 0.46 6.25 0.36 1.61e-9 Lymphocyte percentage of white cells; CESC trans rs8005745 0.505 rs710047 chr14:62118819 C/G cg22828804 chr20:3140466 UBOX5;FASTKD5 -0.41 -6.03 -0.35 5.5e-9 Select biomarker traits; CESC cis rs6087990 0.842 rs4911105 chr20:31330413 G/A cg13636640 chr20:31349939 DNMT3B 0.83 14.67 0.67 4.65e-36 Ulcerative colitis; CESC cis rs965469 1.000 rs6051712 chr20:3265029 T/A cg25506879 chr20:3388711 C20orf194 -0.55 -6.0 -0.35 6.41e-9 IFN-related cytopenia; CESC cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg10556349 chr10:835070 NA 0.58 5.57 0.32 6.1e-8 Eosinophil percentage of granulocytes; CESC cis rs11204677 1 rs11204677 chr1:150574695 C/G cg22823121 chr1:150693482 HORMAD1 -0.36 -5.29 -0.31 2.6e-7 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg10351095 chr21:47802916 PCNT 0.49 6.76 0.38 8.55e-11 Testicular germ cell tumor; CESC cis rs9291683 0.668 rs2241474 chr4:10086015 T/C cg11266682 chr4:10021025 SLC2A9 0.58 10.58 0.54 4.84e-22 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24522804 chr11:86666307 FZD4 0.62 7.06 0.4 1.42e-11 Gut microbiome composition (summer); CESC cis rs798554 0.591 rs1182156 chr7:2901084 G/T cg18446336 chr7:2847575 GNA12 -0.32 -5.13 -0.3 5.6e-7 Height; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg13531596 chr19:39894559 NA -0.48 -6.38 -0.36 8.02e-10 Recombination measurement; CESC cis rs881375 0.967 rs7034492 chr9:123687211 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 5.24 0.31 3.22e-7 Rheumatoid arthritis; CESC cis rs561341 0.824 rs1978115 chr17:30220776 A/C cg00745463 chr17:30367425 LRRC37B -0.62 -6.33 -0.36 1.04e-9 Hip circumference adjusted for BMI; CESC cis rs2243480 1.000 rs906134 chr7:65444288 G/C cg25894440 chr7:65020034 NA -0.68 -5.88 -0.34 1.23e-8 Diabetic kidney disease; CESC cis rs4423214 1.000 rs4944959 chr11:71168234 C/T cg24826892 chr11:71159390 DHCR7 -0.46 -5.39 -0.31 1.59e-7 Vitamin D levels; CESC cis rs9811920 0.660 rs11719468 chr3:99671848 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -6.39 -0.37 7.62e-10 Axial length; CESC cis rs4481887 0.927 rs4345830 chr1:248474845 G/C cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs3785574 0.962 rs114027117 chr17:61939935 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.41 5.07 0.3 7.56e-7 Height; CESC cis rs4423214 0.535 rs1540129 chr11:71129523 C/G cg05163923 chr11:71159392 DHCR7 0.57 7.13 0.4 9.77e-12 Vitamin D levels; CESC cis rs9487051 0.676 rs6568566 chr6:109596792 G/A cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg02931644 chr1:25747376 RHCE 0.39 6.5 0.37 3.99e-10 Erythrocyte sedimentation rate; CESC cis rs9611519 0.929 rs4820425 chr22:41431342 C/A cg03806693 chr22:41940476 POLR3H -0.57 -5.91 -0.34 1.02e-8 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02533120 chr21:33031840 SOD1 0.65 7.65 0.43 3.75e-13 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs7707921 0.767 rs862245 chr5:81585737 A/C cg15871215 chr5:81402204 ATG10 -0.38 -5.28 -0.31 2.71e-7 Breast cancer; CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg07308232 chr7:1071921 C7orf50 -0.41 -5.52 -0.32 8.17e-8 Longevity;Endometriosis; CESC cis rs4319547 0.656 rs7294559 chr12:122837564 C/A cg05707623 chr12:122985044 ZCCHC8 -0.57 -6.51 -0.37 3.74e-10 Body mass index; CESC cis rs12912251 1.000 rs12901215 chr15:38992893 G/A cg01338139 chr15:38987640 C15orf53 -0.47 -5.32 -0.31 2.2e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs977987 0.806 rs4888404 chr16:75428097 G/A cg03315344 chr16:75512273 CHST6 0.4 5.71 0.33 3e-8 Dupuytren's disease; CESC cis rs1843834 0.505 rs940317 chr2:225358118 C/T cg22509189 chr2:225307070 NA -0.41 -5.42 -0.32 1.34e-7 IgE levels in asthmatics (D.p. specific); CESC trans rs6084875 0.620 rs4815735 chr20:4722641 T/C cg10192164 chr16:30419175 ZNF771 -0.5 -6.16 -0.35 2.7e-9 Systemic lupus erythematosus; CESC cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg20701182 chr2:24300061 SF3B14 0.93 10.41 0.54 1.73e-21 Lymphocyte counts; CESC cis rs1728785 0.901 rs1103286 chr16:68578625 C/T cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs75229567 0.618 rs11177848 chr12:70180892 A/G cg10114359 chr12:70132523 RAB3IP 1.34 8.38 0.46 3.17e-15 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs72627509 0.767 rs6853156 chr4:57774843 C/T cg26694713 chr4:57773883 REST 0.58 5.58 0.32 5.81e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9457247 0.967 rs1187532 chr6:167382020 G/A cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.27e-8 Crohn's disease; CESC cis rs1348850 0.914 rs7604673 chr2:178392346 A/G cg22681709 chr2:178499509 PDE11A -0.41 -5.83 -0.34 1.59e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1559088 0.901 rs12610053 chr19:33582606 A/G cg27124370 chr19:33622961 WDR88 0.47 6.15 0.35 2.91e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.52 0.54 7.57e-22 Prudent dietary pattern; CESC cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 5.86e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6120849 0.754 rs6087666 chr20:33640242 G/A cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs3820928 1.000 rs3731593 chr2:227773924 A/G cg05526886 chr2:227700861 RHBDD1 -0.43 -5.53 -0.32 7.83e-8 Pulmonary function; CESC cis rs12477438 0.520 rs13004491 chr2:99738008 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.87 0.7 2.48e-40 Chronic sinus infection; CESC cis rs4268898 0.552 rs11125454 chr2:24373669 T/C cg06627628 chr2:24431161 ITSN2 0.6 8.23 0.45 8.28e-15 Asthma; CESC cis rs67311347 1.000 rs2276868 chr3:40498845 C/T cg24209194 chr3:40518798 ZNF619 -0.46 -6.04 -0.35 5.1e-9 Renal cell carcinoma; CESC cis rs4148883 0.675 rs116265877 chr4:100096896 G/A cg13256891 chr4:100009986 ADH5 0.53 6.93 0.39 3.27e-11 Alcohol dependence; CESC cis rs1018836 0.608 rs7843149 chr8:91474961 C/T cg16814680 chr8:91681699 NA -0.54 -7.48 -0.42 1.09e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9815354 0.812 rs60927633 chr3:41844010 C/T cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs761746 0.847 rs4820976 chr22:31876466 G/A cg25791279 chr22:32026902 PISD -0.5 -5.57 -0.32 6.21e-8 Intelligence; CESC cis rs2204008 0.658 rs11495742 chr12:38395688 C/A cg13010199 chr12:38710504 ALG10B 0.54 6.67 0.38 1.45e-10 Bladder cancer; CESC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -6.93 -0.39 3.2e-11 Bipolar disorder and schizophrenia; CESC trans rs17685 0.753 rs4728550 chr7:75670988 C/A cg19862616 chr7:65841803 NCRNA00174 -0.84 -12.47 -0.61 2.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs10203711 0.901 rs907104 chr2:239564564 T/G cg14580085 chr2:239553406 NA 0.34 5.09 0.3 6.77e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs926938 0.527 rs360665 chr1:115478503 A/T cg12756093 chr1:115239321 AMPD1 0.45 6.18 0.35 2.44e-9 Autism; CESC cis rs56399783 0.901 rs757788 chr7:2836433 A/G cg19731401 chr7:2775893 GNA12 0.65 5.71 0.33 2.96e-8 Childhood ear infection; CESC trans rs9833726 0.799 rs11710933 chr3:86136781 A/T cg10416071 chr15:75628863 COMMD4 0.59 6.12 0.35 3.37e-9 Breast cancer; CESC cis rs1728785 0.901 rs1170437 chr16:68607943 C/T cg02972257 chr16:68554789 NA -0.6 -6.82 -0.39 6.06e-11 Ulcerative colitis; CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.48 6.29 0.36 1.32e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7914558 1.000 rs10786733 chr10:104794947 G/A cg04362960 chr10:104952993 NT5C2 0.47 6.23 0.36 1.8e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1008375 0.932 rs12500912 chr4:17603318 C/T cg16339924 chr4:17578868 LAP3 0.68 8.73 0.47 2.9e-16 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs936229 0.749 rs4886633 chr15:75178207 G/A cg10253484 chr15:75165896 SCAMP2 -0.45 -5.14 -0.3 5.28e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08156809 chr7:74071310 GTF2I -0.44 -6.21 -0.36 1.99e-9 Fibrinogen levels; CESC cis rs72781680 0.948 rs72796319 chr2:24133027 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs1256061 0.603 rs1256039 chr14:64738979 G/C cg21174375 chr14:64681225 SYNE2 0.51 6.82 0.39 6.15e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs11088226 1.000 rs11088226 chr21:33925531 C/G cg09050820 chr6:167586206 TCP10L2 0.63 6.31 0.36 1.18e-9 Gastritis; CESC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg18252515 chr7:66147081 NA 0.43 5.73 0.33 2.67e-8 Aortic root size; CESC cis rs3733585 0.673 rs4311316 chr4:9955971 A/C cg00071950 chr4:10020882 SLC2A9 0.66 10.7 0.55 1.99e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2730245 0.636 rs710421 chr7:158668575 T/C cg14689365 chr7:158441557 NCAPG2 0.42 5.23 0.31 3.5e-7 Height; CESC cis rs56104184 0.775 rs73061697 chr19:49400000 C/T cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg09177884 chr7:1199841 ZFAND2A -0.54 -7.19 -0.4 6.76e-12 Longevity;Endometriosis; CESC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg16545954 chr1:2118288 C1orf86 0.37 7.11 0.4 1.05e-11 Height; CESC cis rs7116495 1.000 rs1939247 chr11:71740521 A/T cg10381502 chr11:71823885 C11orf51 -0.67 -5.51 -0.32 8.66e-8 Severe influenza A (H1N1) infection; CESC cis rs17826219 0.706 rs609472 chr17:28951427 T/C cg13385521 chr17:29058706 SUZ12P 0.6 5.16 0.3 4.89e-7 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12038521 chr19:2111714 AP3D1 -0.63 -7.17 -0.4 7.47e-12 Gut microbiome composition (summer); CESC trans rs62103177 0.810 rs62103197 chr18:77632923 G/A cg05926928 chr17:57297772 GDPD1 1.23 10.32 0.54 3.37e-21 Opioid sensitivity; CESC cis rs6545883 1.000 rs6545883 chr2:61772257 A/G cg15711740 chr2:61764176 XPO1 -0.43 -5.7 -0.33 3.23e-8 Tuberculosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11662452 chr6:126964983 NA -0.54 -6.96 -0.39 2.75e-11 Gut microbiome composition (summer); CESC cis rs9549367 0.713 rs2480949 chr13:113853149 T/C cg00898013 chr13:113819073 PROZ 0.46 6.9 0.39 3.81e-11 Platelet distribution width; CESC cis rs888194 1.000 rs888194 chr12:109986918 C/G cg19025524 chr12:109796872 NA -0.37 -5.48 -0.32 9.75e-8 Neuroticism; CESC cis rs9443189 0.570 rs6903124 chr6:76290079 A/C cg01950844 chr6:76311363 SENP6 0.87 9.54 0.51 9.61e-19 Prostate cancer; CESC cis rs9513593 1.000 rs12875982 chr13:99850615 C/T cg21788972 chr13:99853209 UBAC2 0.63 7.14 0.4 8.76e-12 Psoriasis; CESC cis rs17826219 0.636 rs2449770 chr17:29101064 G/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Body mass index; CESC cis rs4563143 0.592 rs12151001 chr19:29283386 C/G cg12667521 chr19:29218732 NA 0.48 5.92 0.34 1.02e-8 Methadone dose in opioid dependence; CESC cis rs6032067 0.777 rs116517830 chr20:43784872 G/A cg10761708 chr20:43804764 PI3 0.55 6.51 0.37 3.7e-10 Blood protein levels; CESC cis rs2486288 0.656 rs11637364 chr15:45579238 C/T cg09092052 chr15:45571596 NA 0.45 5.29 0.31 2.58e-7 Glomerular filtration rate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21207699 chr9:8713788 PTPRD -0.36 -6.0 -0.35 6.48e-9 Gambling; CESC trans rs995758 0.647 rs1489761 chr4:145455491 A/G cg03219697 chr8:145653915 VPS28 0.43 6.23 0.36 1.81e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; CESC cis rs7561273 0.609 rs3795953 chr2:24345707 C/G cg20701182 chr2:24300061 SF3B14 0.46 6.01 0.35 6.27e-9 Quantitative traits; CESC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg24324837 chr19:49891574 CCDC155 0.52 5.92 0.34 9.74e-9 Multiple sclerosis; CESC cis rs926938 0.584 rs6689326 chr1:115369112 T/A cg12756093 chr1:115239321 AMPD1 -0.45 -6.09 -0.35 3.95e-9 Autism; CESC cis rs7659604 0.628 rs6838153 chr4:122720999 A/G cg20573242 chr4:122745356 CCNA2 0.57 6.92 0.39 3.45e-11 Type 2 diabetes; CESC cis rs28829049 0.597 rs71645438 chr1:19502349 G/A cg13387374 chr1:19411106 UBR4 0.43 5.45 0.32 1.13e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs7223966 1.000 rs11657120 chr17:61857218 G/A cg11494091 chr17:61959527 GH2 0.38 5.18 0.3 4.33e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7312774 0.618 rs3803122 chr12:107354680 G/A cg16260113 chr12:107380972 MTERFD3 0.82 7.48 0.42 1.11e-12 Severe influenza A (H1N1) infection; CESC cis rs798766 1.000 rs2166580 chr4:1743169 G/A cg05874882 chr4:1763078 NA -0.56 -7.19 -0.4 6.5e-12 Bladder cancer;Urinary bladder cancer; CESC cis rs909674 0.731 rs6001594 chr22:39837472 C/T cg11247378 chr22:39784982 NA -0.61 -8.63 -0.47 5.91e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg15112475 chr7:1198522 ZFAND2A -0.45 -7.28 -0.41 3.84e-12 Longevity;Endometriosis; CESC cis rs12348691 0.503 rs4743138 chr9:100614296 C/T cg13688889 chr9:100608707 NA 0.88 13.78 0.65 6.04e-33 Alopecia areata; CESC cis rs11098499 0.863 rs10030660 chr4:120436704 G/A cg24375607 chr4:120327624 NA 0.43 5.13 0.3 5.73e-7 Corneal astigmatism; CESC cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.78 8.21 0.45 9.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs916888 0.773 rs199535 chr17:44822662 A/G cg17911788 chr17:44343683 NA -0.61 -8.3 -0.45 5.38e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7115242 0.748 rs1035237 chr11:116727850 G/C cg01368799 chr11:117014884 PAFAH1B2 0.59 5.19 0.3 4.26e-7 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11989942 chr17:80067146 CCDC57 -0.58 -6.72 -0.38 1.11e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg27170947 chr2:26402098 FAM59B 0.87 9.89 0.52 7.6e-20 Gut microbiome composition (summer); CESC trans rs11098499 0.874 rs9995277 chr4:120108603 G/A cg25214090 chr10:38739885 LOC399744 0.58 7.69 0.43 2.87e-13 Corneal astigmatism; CESC cis rs1008375 0.966 rs2191504 chr4:17675592 C/G cg16339924 chr4:17578868 LAP3 0.51 6.44 0.37 5.73e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.55 -7.52 -0.42 8.28e-13 Menopause (age at onset); CESC cis rs9457247 0.967 rs385460 chr6:167403888 A/T cg23791538 chr6:167370224 RNASET2 -0.59 -8.42 -0.46 2.44e-15 Crohn's disease; CESC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.92 9.76 0.51 2.07e-19 Platelet count; CESC cis rs11122272 0.764 rs4486439 chr1:231477470 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.34 8.37e-9 Hemoglobin concentration; CESC cis rs9733 0.596 rs12089989 chr1:150715782 G/A cg17724175 chr1:150552817 MCL1 0.4 6.54 0.37 3.2e-10 Tonsillectomy; CESC cis rs9658691 0.607 rs3740281 chr10:90772150 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -5.34 -0.31 2e-7 Mosquito bite size; CESC cis rs9457247 1.000 rs932644 chr6:167404187 A/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.42 -0.46 2.44e-15 Crohn's disease; CESC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1865721 0.839 rs59718187 chr18:73144032 C/T cg26385618 chr18:73139727 C18orf62 -0.52 -8.31 -0.45 5.15e-15 Intelligence; CESC cis rs11078597 0.767 rs4525526 chr17:1650125 T/C cg18436246 chr17:1640651 WDR81 0.61 7.31 0.41 3.24e-12 Serum albumin level; CESC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg14893161 chr1:205819251 PM20D1 0.89 14.74 0.67 2.48e-36 Menarche (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00114008 chr1:27114423 PIGV -0.45 -6.11 -0.35 3.61e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17666538 0.585 rs10090260 chr8:608034 T/C cg07234876 chr8:600039 NA 0.86 6.49 0.37 4.23e-10 IgG glycosylation; CESC cis rs7605827 0.866 rs9287665 chr2:15667263 A/T cg19274914 chr2:15703543 NA 0.38 6.8 0.39 7.12e-11 Educational attainment (years of education); CESC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg22903471 chr2:27725779 GCKR -0.5 -7.08 -0.4 1.31e-11 Total body bone mineral density; CESC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg18904891 chr8:8559673 CLDN23 0.64 7.44 0.42 1.45e-12 Obesity-related traits; CESC cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg00409905 chr10:38381863 ZNF37A -0.44 -5.88 -0.34 1.22e-8 Extrinsic epigenetic age acceleration; CESC cis rs9309473 0.948 rs2421550 chr2:73658686 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -6.35 -0.36 9.42e-10 Metabolite levels; CESC cis rs4588572 0.643 rs10043027 chr5:77792707 T/C cg11547950 chr5:77652471 NA -0.43 -5.53 -0.32 7.68e-8 Triglycerides; CESC cis rs75804782 0.521 rs55988884 chr2:239396930 G/A cg18131467 chr2:239335373 ASB1 -0.69 -5.73 -0.33 2.66e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs7474896 0.616 rs2474561 chr10:38373544 C/T cg25427524 chr10:38739819 LOC399744 -0.56 -6.0 -0.35 6.41e-9 Obesity (extreme); CESC cis rs7605827 0.930 rs6725454 chr2:15692879 C/A cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs2486288 0.656 rs11631021 chr15:45556829 A/G cg09092052 chr15:45571596 NA 0.48 5.62 0.33 4.73e-8 Glomerular filtration rate; CESC trans rs7618501 0.966 rs2246832 chr3:49881134 A/T cg21659725 chr3:3221576 CRBN 0.81 12.82 0.62 1.34e-29 Intelligence (multi-trait analysis); CESC cis rs7786808 0.586 rs7794256 chr7:158206214 T/G cg09998033 chr7:158218633 PTPRN2 0.38 5.58 0.32 5.97e-8 Obesity-related traits; CESC cis rs4478858 0.698 rs6669381 chr1:31833506 A/G cg00250761 chr1:31883323 NA -0.26 -5.07 -0.3 7.56e-7 Alcohol dependence; CESC cis rs2412459 1.000 rs8023482 chr15:40307095 A/C cg20255370 chr15:40268687 EIF2AK4 -0.53 -5.23 -0.31 3.51e-7 Response to haloperidol in psychosis; CESC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg23758822 chr17:41437982 NA 1.05 16.25 0.71 1.17e-41 Menopause (age at onset); CESC trans rs61931739 0.534 rs1817761 chr12:34105719 C/T cg26384229 chr12:38710491 ALG10B 0.59 8.18 0.45 1.17e-14 Morning vs. evening chronotype; CESC cis rs863345 0.604 rs12044288 chr1:158463863 C/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.55e-11 Pneumococcal bacteremia; CESC cis rs9733 0.596 rs12089989 chr1:150715782 G/A cg18016565 chr1:150552671 MCL1 0.34 5.3 0.31 2.44e-7 Tonsillectomy; CESC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg24209194 chr3:40518798 ZNF619 0.52 6.48 0.37 4.52e-10 Renal cell carcinoma; CESC cis rs3820928 0.605 rs10186145 chr2:227781150 A/G cg05526886 chr2:227700861 RHBDD1 -0.56 -7.74 -0.43 2.12e-13 Pulmonary function; CESC cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg14416269 chr4:6271139 WFS1 -0.47 -6.45 -0.37 5.26e-10 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs12476592 0.602 rs10865337 chr2:63720906 C/T cg17519650 chr2:63277830 OTX1 -0.49 -5.43 -0.32 1.3e-7 Childhood ear infection; CESC trans rs5769765 0.862 rs9616384 chr22:50313082 C/T cg09872104 chr7:134855509 C7orf49 -0.55 -6.31 -0.36 1.19e-9 Schizophrenia; CESC cis rs2070488 0.775 rs2070489 chr3:38519424 A/G cg24069376 chr3:38537580 EXOG 0.34 5.77 0.33 2.26e-8 Electrocardiographic conduction measures; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19167683 chr11:57194495 SLC43A3 -0.48 -6.0 -0.35 6.35e-9 Ulcerative colitis; CESC trans rs877282 0.898 rs10904546 chr10:757222 A/G cg22713356 chr15:30763199 NA 1.05 9.16 0.49 1.45e-17 Uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10011777 chr1:2451511 PANK4 -0.54 -6.42 -0.37 6.29e-10 Gut microbiome composition (summer); CESC cis rs8060686 0.641 rs73598006 chr16:68074454 C/G cg26727032 chr16:67993705 SLC12A4 -0.52 -6.4 -0.37 6.82e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs17293817 0.589 rs36106483 chr10:1418362 A/G cg04271617 chr10:1416546 ADARB2 0.35 5.6 0.33 5.24e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs5760092 0.755 rs4585126 chr22:24270005 T/C cg10150615 chr22:24372951 LOC391322 0.5 6.27 0.36 1.44e-9 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs9796 0.558 rs4445868 chr15:41531991 C/T cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.47 -0.37 4.78e-10 Menopause (age at onset); CESC cis rs3768617 0.510 rs10752900 chr1:183086238 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.49e-35 Fuchs's corneal dystrophy; CESC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg00684032 chr4:1343700 KIAA1530 0.39 5.43 0.32 1.27e-7 Obesity-related traits; CESC cis rs7809950 0.954 rs2520241 chr7:107135443 A/G cg23024343 chr7:107201750 COG5 -0.43 -6.21 -0.36 2.03e-9 Coronary artery disease; CESC cis rs7772486 0.686 rs1337841 chr6:146059487 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.88 -0.39 4.18e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs8114671 0.562 rs2273683 chr20:33509523 C/T cg07148914 chr20:33460835 GGT7 0.52 6.79 0.39 7.24e-11 Height; CESC cis rs694739 0.930 rs574087 chr11:64102948 A/G cg23796481 chr11:64053134 BAD;GPR137 0.68 8.67 0.47 4.4e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 3.9e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs67478160 0.634 rs941473 chr14:104201869 C/G cg01849466 chr14:104193079 ZFYVE21 -0.54 -7.83 -0.43 1.14e-13 Schizophrenia; CESC trans rs11098499 0.779 rs10857066 chr4:120286596 C/T cg25214090 chr10:38739885 LOC399744 0.65 9.04 0.49 3.36e-17 Corneal astigmatism; CESC cis rs1267303 0.675 rs1267309 chr1:46987342 G/A cg25110126 chr1:46999211 NA -0.72 -8.88 -0.48 1.04e-16 Monobrow; CESC cis rs7193541 0.965 rs28616016 chr16:74676964 T/C cg01733217 chr16:74700730 RFWD3 0.93 13.38 0.63 1.58e-31 Multiple myeloma; CESC cis rs9487051 0.768 rs458740 chr6:109525527 C/T cg01475377 chr6:109611718 NA -0.46 -6.91 -0.39 3.56e-11 Reticulocyte fraction of red cells; CESC cis rs1953600 0.729 rs2819872 chr10:81906269 A/G cg00277334 chr10:82204260 NA 0.52 7.71 0.43 2.55e-13 Sarcoidosis; CESC cis rs7084402 0.967 rs7087528 chr10:60301294 A/T cg07615347 chr10:60278583 BICC1 -0.57 -8.6 -0.47 7.13e-16 Refractive error; CESC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg13206674 chr6:150067644 NUP43 0.46 6.63 0.38 1.84e-10 Lung cancer; CESC cis rs637571 0.584 rs659824 chr11:65636509 A/G cg02427764 chr11:65769310 BANF1;EIF1AD -0.42 -5.1 -0.3 6.54e-7 Eosinophil percentage of white cells; CESC cis rs1878931 0.615 rs4786412 chr16:3440390 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 1.03 17.14 0.73 7.81e-45 Body mass index (adult); CESC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg11965913 chr1:205819406 PM20D1 0.83 13.74 0.64 8.48e-33 Menarche (age at onset); CESC trans rs1814175 0.645 rs847639 chr11:49919603 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg11890956 chr21:40555474 PSMG1 -0.97 -15.94 -0.7 1.46e-40 Cognitive function; CESC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg27165867 chr14:105738592 BRF1 -0.56 -6.26 -0.36 1.51e-9 Mean platelet volume;Platelet distribution width; CESC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg09455208 chr3:40491958 NA 0.52 8.48 0.46 1.56e-15 Renal cell carcinoma; CESC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg03517284 chr6:25882590 NA 0.43 5.86 0.34 1.37e-8 Intelligence (multi-trait analysis); CESC trans rs11098499 0.954 rs10031483 chr4:120422636 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.78 0.51 1.7e-19 Corneal astigmatism; CESC cis rs12477438 0.520 rs6717723 chr2:99756930 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.04 0.68 2.28e-37 Chronic sinus infection; CESC cis rs8114671 0.804 rs6060139 chr20:33566499 T/C cg06115741 chr20:33292138 TP53INP2 0.46 5.48 0.32 1e-7 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07005173 chr17:7977057 ALOX12B 0.43 6.01 0.35 6.11e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9303401 0.573 rs62081879 chr17:57181524 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.0 12.4 0.61 3.86e-28 Cognitive test performance; CESC cis rs2204008 0.744 rs11182316 chr12:38499552 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.71 0.38 1.21e-10 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22122542 chr4:113486179 C4orf21 -0.56 -6.64 -0.38 1.82e-10 Gut microbiome composition (summer); CESC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12586317 0.547 rs13379372 chr14:35483882 A/C cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.22e-22 Psoriasis; CESC cis rs4450798 0.793 rs60991429 chr3:13751113 G/A cg05589046 chr3:13742034 LOC285375 0.38 5.6 0.33 5.41e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6546550 0.935 rs10865380 chr2:70091246 T/C cg02498382 chr2:70120550 SNRNP27 -0.35 -5.97 -0.34 7.62e-9 Prevalent atrial fibrillation; CESC cis rs2997447 0.761 rs61776585 chr1:26438498 G/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg05457628 chr5:178986728 RUFY1 0.5 7.09 0.4 1.2e-11 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16101703 chr5:65440440 SFRS12 0.51 6.09 0.35 3.95e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.45e-30 Colonoscopy-negative controls vs population controls; CESC cis rs12136530 0.774 rs4911996 chr1:19765205 C/G cg01832549 chr1:19774989 CAPZB 0.47 6.49 0.37 4.25e-10 Lead levels in blood; CESC cis rs7762018 1.000 rs4716375 chr6:170071218 A/C cg05834625 chr6:170176447 C6orf70 0.62 7.46 0.42 1.25e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9611565 0.649 rs5751144 chr22:42128097 A/G cg06481639 chr22:41940642 POLR3H -0.46 -5.38 -0.31 1.62e-7 Vitiligo; CESC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.43e-7 Tonsillectomy; CESC cis rs6089584 0.546 rs4925337 chr20:60637637 T/C cg06108461 chr20:60628389 TAF4 -0.56 -7.34 -0.41 2.61e-12 Body mass index; CESC cis rs6460942 0.915 rs75732743 chr7:12454095 C/T cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs67478160 0.619 rs12885018 chr14:104273812 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.19 -0.4 6.56e-12 Schizophrenia; CESC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg07507251 chr3:52567010 NT5DC2 0.32 5.63 0.33 4.6e-8 Electroencephalogram traits; CESC cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg18305652 chr10:134549665 INPP5A 0.48 7.01 0.4 1.94e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.5 0.37 4.03e-10 Bipolar disorder; CESC cis rs1707322 1.000 rs7526369 chr1:46390560 G/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg11247378 chr22:39784982 NA -0.62 -9.06 -0.49 2.88e-17 Intelligence (multi-trait analysis); CESC cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg15556689 chr8:8085844 FLJ10661 0.62 8.11 0.45 1.85e-14 Mood instability; CESC cis rs796364 0.951 rs281793 chr2:200847990 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.89 8.77 0.47 2.23e-16 Schizophrenia; CESC cis rs933688 1.000 rs332531 chr5:90790451 G/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.8 10.1 0.53 1.62e-20 Smoking behavior; CESC cis rs15676 0.783 rs10988134 chr9:131595407 C/T cg00228799 chr9:131580591 ENDOG -0.55 -7.0 -0.4 2.1e-11 Blood metabolite levels; CESC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg22920501 chr2:26401640 FAM59B 0.93 10.89 0.56 4.54e-23 Gut microbiome composition (summer); CESC cis rs3857067 0.806 rs7669168 chr4:95104881 G/T cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.07 -0.49 2.67e-17 QT interval; CESC cis rs1348850 0.914 rs12469386 chr2:178358281 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.71 -9.95 -0.52 5.04e-20 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3809863 0.646 rs9899121 chr17:45395144 C/T cg08085267 chr17:45401833 C17orf57 -0.69 -9.19 -0.49 1.16e-17 Glaucoma (primary open-angle); CESC cis rs2072732 0.821 rs7339938 chr1:2963493 G/C cg03976712 chr1:2946727 NA 0.33 5.78 0.33 2.08e-8 Plateletcrit; CESC cis rs933688 0.938 rs10063683 chr5:90714595 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.82 0.59 3.43e-26 Smoking behavior; CESC cis rs7824557 0.564 rs2572389 chr8:11236392 T/C cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.52e-14 Retinal vascular caliber; CESC cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg10057126 chr4:77819792 ANKRD56 0.58 8.4 0.46 2.79e-15 Emphysema distribution in smoking; CESC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg24879335 chr3:133465180 TF 0.37 6.47 0.37 4.62e-10 Iron status biomarkers; CESC cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg21918786 chr6:109611834 NA -0.4 -5.94 -0.34 8.87e-9 Reticulocyte fraction of red cells; CESC cis rs2731664 0.792 rs652242 chr5:176873010 C/G cg23176889 chr5:176863531 GRK6 -0.63 -10.9 -0.56 4.08e-23 Intelligence (multi-trait analysis); CESC cis rs36051895 0.623 rs10118267 chr9:5243736 T/C cg02405213 chr9:5042618 JAK2 -0.52 -6.22 -0.36 1.96e-9 Pediatric autoimmune diseases; CESC cis rs2979489 0.891 rs2915591 chr8:30395948 C/G cg26383811 chr8:30366931 RBPMS -0.81 -10.03 -0.52 2.89e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs735396 1.000 rs2464195 chr12:121435475 G/A cg25281562 chr12:121454272 C12orf43 0.39 5.12 0.3 5.93e-7 N-glycan levels; CESC cis rs6460942 0.908 rs6956500 chr7:12232120 T/C cg06484146 chr7:12443880 VWDE -0.47 -5.09 -0.3 6.93e-7 Coronary artery disease; CESC cis rs7267979 1.000 rs6037095 chr20:25335687 A/G cg08601574 chr20:25228251 PYGB -0.38 -5.49 -0.32 9.3e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7617773 0.817 rs9834095 chr3:48327751 G/A cg11946769 chr3:48343235 NME6 0.8 10.89 0.56 4.71e-23 Coronary artery disease; CESC cis rs910316 0.763 rs13712 chr14:75483812 T/C cg11812906 chr14:75593930 NEK9 0.82 13.58 0.64 3.1e-32 Height; CESC cis rs2820292 0.619 rs11576508 chr1:201824390 G/A cg11586189 chr1:201857591 SHISA4 -0.36 -5.81 -0.34 1.75e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs35110281 0.667 rs4818859 chr21:45117120 G/A cg04455712 chr21:45112962 RRP1B 0.47 7.13 0.4 9.39e-12 Mean corpuscular volume; CESC cis rs6009527 1.000 rs6009527 chr22:49570587 C/T cg12746016 chr22:49560550 NA 0.35 5.44 0.32 1.19e-7 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); CESC cis rs10465746 0.725 rs4907185 chr1:84336047 T/C cg10977910 chr1:84465055 TTLL7 0.56 7.78 0.43 1.64e-13 Obesity-related traits; CESC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg00129232 chr17:37814104 STARD3 0.48 6.05 0.35 5e-9 Glomerular filtration rate (creatinine); CESC cis rs1023500 0.505 rs134885 chr22:42673811 C/G cg15557168 chr22:42548783 NA -0.47 -7.35 -0.41 2.46e-12 Schizophrenia; CESC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.44 -5.61 -0.33 5.03e-8 Tonsillectomy; CESC cis rs644799 1.000 rs527899 chr11:95529242 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10129255 0.556 rs6576224 chr14:107186236 G/A cg23076370 chr14:107095027 NA -0.65 -9.62 -0.51 5.59e-19 Kawasaki disease; CESC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.95 -0.56 2.82e-23 Alzheimer's disease; CESC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg11663144 chr21:46675770 NA -0.61 -9.69 -0.51 3.44e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1538970 0.962 rs2185549 chr1:45814103 C/T cg05343316 chr1:45956843 TESK2 -0.83 -11.34 -0.57 1.46e-24 Platelet count; CESC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg19592336 chr6:28129416 ZNF389 0.61 8.24 0.45 8.13e-15 Parkinson's disease; CESC cis rs1949733 1.000 rs2631740 chr4:8484106 C/A cg11789530 chr4:8429930 ACOX3 -0.78 -11.13 -0.56 7.31e-24 Response to antineoplastic agents; CESC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.59 0.42 5.31e-13 Prudent dietary pattern; CESC cis rs7208859 0.673 rs7211776 chr17:29120196 T/G cg19761014 chr17:28927070 LRRC37B2 0.68 6.72 0.38 1.11e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4689388 0.856 rs3200 chr4:6304878 C/T cg25554036 chr4:6271136 WFS1 0.57 9.38 0.5 3.11e-18 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs9326248 0.648 rs11216257 chr11:116932561 C/T cg01368799 chr11:117014884 PAFAH1B2 0.47 5.06 0.3 7.69e-7 Blood protein levels; CESC cis rs35160687 0.644 rs4832264 chr2:86486834 A/G cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.23 -0.31 3.51e-7 Night sleep phenotypes; CESC cis rs763121 0.853 rs6001204 chr22:39100239 T/C cg21395723 chr22:39101663 GTPBP1 0.5 6.81 0.39 6.57e-11 Menopause (age at onset); CESC cis rs9868809 0.542 rs9873726 chr3:48712367 C/T cg06212747 chr3:49208901 KLHDC8B -0.59 -5.19 -0.3 4.1e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg05283184 chr6:79620031 NA 0.41 6.48 0.37 4.41e-10 Intelligence (multi-trait analysis); CESC cis rs9888739 0.668 rs9933520 chr16:31343386 A/G cg15817542 chr16:31343056 ITGAM -0.54 -7.68 -0.43 3.13e-13 Systemic lupus erythematosus; CESC cis rs35955747 0.902 rs739427 chr22:31659101 C/G cg02404636 chr22:31891804 SFI1 0.37 5.06 0.3 7.96e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg21963583 chr11:68658836 MRPL21 0.38 5.71 0.33 2.96e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9527 0.501 rs12244388 chr10:104640052 G/A cg04362960 chr10:104952993 NT5C2 0.49 6.13 0.35 3.15e-9 Arsenic metabolism; CESC cis rs6088580 0.505 rs6142219 chr20:33256345 G/A cg08999081 chr20:33150536 PIGU -0.46 -6.42 -0.37 6.23e-10 Glomerular filtration rate (creatinine); CESC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg06456125 chr7:65229604 NA 0.4 5.3 0.31 2.4e-7 Aortic root size; CESC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg04414720 chr1:150670196 GOLPH3L -0.37 -5.26 -0.31 3.03e-7 Tonsillectomy; CESC cis rs950776 0.714 rs17408276 chr15:78881618 T/C cg06917634 chr15:78832804 PSMA4 0.6 7.2 0.4 6.09e-12 Sudden cardiac arrest; CESC cis rs910316 0.789 rs12894419 chr14:75471802 C/T cg08847533 chr14:75593920 NEK9 0.89 15.53 0.69 3.94e-39 Height; CESC cis rs3761847 0.593 rs1468673 chr9:123809890 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.36 5.2 0.3 4.03e-7 Rheumatoid arthritis; CESC cis rs7927771 0.524 rs10838777 chr11:47860954 A/C cg20307385 chr11:47447363 PSMC3 0.63 8.77 0.47 2.17e-16 Subjective well-being; CESC cis rs637571 0.676 rs1151523 chr11:65665200 C/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.51 -6.5 -0.37 3.91e-10 Eosinophil percentage of white cells; CESC cis rs2295499 0.673 rs2298964 chr4:2699607 G/C cg27239842 chr4:2403781 ZFYVE28 -0.32 -5.33 -0.31 2.11e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.09 0.3 6.74e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 13.24 0.63 4.75e-31 Platelet count; CESC trans rs9467711 0.606 rs2073529 chr6:26375159 C/T cg06606381 chr12:133084897 FBRSL1 0.82 6.9 0.39 3.82e-11 Autism spectrum disorder or schizophrenia; CESC cis rs17431357 1.000 rs73230308 chr12:120986986 G/A cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg02592271 chr2:27665507 KRTCAP3 -0.33 -6.36 -0.36 8.88e-10 Total body bone mineral density; CESC cis rs7647973 0.600 rs11920267 chr3:49275964 G/A cg03060546 chr3:49711283 APEH 0.52 7.03 0.4 1.7e-11 Menarche (age at onset); CESC cis rs854765 0.583 rs11871899 chr17:17826748 C/G cg09796270 chr17:17721594 SREBF1 0.46 6.42 0.37 6.23e-10 Total body bone mineral density; CESC cis rs6580649 0.941 rs7310579 chr12:48427523 G/A cg24011408 chr12:48396354 COL2A1 -0.42 -5.26 -0.31 2.93e-7 Lung cancer; CESC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.38 -0.31 1.61e-7 Parkinson's disease; CESC cis rs3126085 0.877 rs4456098 chr1:152176034 C/T cg26876637 chr1:152193138 HRNR 0.45 5.14 0.3 5.28e-7 Atopic dermatitis; CESC cis rs9399401 0.667 rs1329707 chr6:142724439 T/C cg04461802 chr6:142623433 GPR126 0.42 6.02 0.35 5.68e-9 Chronic obstructive pulmonary disease; CESC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg16049864 chr8:95962084 TP53INP1 -0.68 -12.35 -0.6 5.62e-28 Type 2 diabetes; CESC cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg00149659 chr3:10157352 C3orf10 0.98 11.92 0.59 1.59e-26 Alzheimer's disease; CESC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg26587870 chr6:27730563 NA -0.55 -5.05 -0.3 8.28e-7 Depression; CESC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg18404041 chr3:52824283 ITIH1 -0.46 -7.44 -0.42 1.45e-12 Bipolar disorder; CESC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg08736216 chr1:53307985 ZYG11A 0.42 7.11 0.4 1.06e-11 Monocyte count; CESC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.79e-7 Gut microbiome composition (summer); CESC cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg18569988 chr3:195679450 NA 0.37 5.07 0.3 7.6e-7 Pancreatic cancer; CESC cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.2 0.3 4.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7523050 0.642 rs12044219 chr1:109481236 T/C cg08274380 chr1:109419600 GPSM2 0.77 5.45 0.32 1.18e-7 Fat distribution (HIV); CESC cis rs7542091 0.669 rs11119357 chr1:210042382 C/T cg09509183 chr1:209979624 IRF6 0.39 5.53 0.32 7.6e-8 Monobrow; CESC cis rs1008375 0.932 rs4698650 chr4:17692878 G/C cg16339924 chr4:17578868 LAP3 0.6 7.44 0.42 1.45e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs911555 0.755 rs9671414 chr14:103967299 C/T cg24130564 chr14:104152367 KLC1 0.49 6.12 0.35 3.37e-9 Intelligence (multi-trait analysis); CESC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg22823121 chr1:150693482 HORMAD1 0.46 6.41 0.37 6.7e-10 Melanoma; CESC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg09658497 chr7:2847517 GNA12 -0.35 -5.09 -0.3 6.89e-7 Height; CESC cis rs113835537 0.529 rs4930378 chr11:66255515 T/C cg24851651 chr11:66362959 CCS 0.44 5.73 0.33 2.76e-8 Airway imaging phenotypes; CESC cis rs7927771 0.507 rs7111606 chr11:47787538 G/A cg20307385 chr11:47447363 PSMC3 0.61 8.59 0.47 7.41e-16 Subjective well-being; CESC cis rs7267979 0.966 rs7270835 chr20:25435067 C/T cg08601574 chr20:25228251 PYGB 0.36 5.12 0.3 5.95e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7395581 0.959 rs2167079 chr11:47270255 C/T cg25783544 chr11:47291846 MADD 0.59 7.65 0.43 3.78e-13 HDL cholesterol; CESC cis rs688020 1.000 rs673500 chr7:4229445 C/G cg24441899 chr7:4244372 SDK1 -0.3 -5.12 -0.3 5.86e-7 Liver fibrosis in pediatric non-alcoholic fatty acid liver disease; CESC cis rs4835473 0.932 rs17762299 chr4:144698349 A/G cg25736465 chr4:144833511 NA -0.33 -5.18 -0.3 4.39e-7 Immature fraction of reticulocytes; CESC cis rs1044826 0.597 rs6803593 chr3:139193987 T/C cg00490450 chr3:139108681 COPB2 0.44 5.37 0.31 1.77e-7 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03289602 chr19:11708437 ZNF627 -0.46 -6.34 -0.36 9.74e-10 Fibrinogen levels; CESC cis rs10751667 1.000 rs10794357 chr11:973374 T/C cg06064525 chr11:970664 AP2A2 -0.37 -6.49 -0.37 4.32e-10 Alzheimer's disease (late onset); CESC cis rs2882667 0.858 rs11948429 chr5:138458584 G/A cg04439458 chr5:138467593 SIL1 -0.34 -5.29 -0.31 2.52e-7 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03576530 chr14:105167973 INF2 0.44 6.18 0.35 2.44e-9 Fibrinogen levels; CESC cis rs2235642 0.592 rs743963 chr16:1657350 A/T cg09080909 chr16:1797204 MAPK8IP3 -0.39 -5.28 -0.31 2.72e-7 Coronary artery disease; CESC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg11764359 chr7:65958608 NA -0.77 -11.27 -0.57 2.43e-24 Aortic root size; CESC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg11987759 chr7:65425863 GUSB -0.47 -6.32 -0.36 1.08e-9 Calcium levels; CESC cis rs17376456 0.825 rs74825443 chr5:93254973 T/C cg21475434 chr5:93447410 FAM172A 0.74 6.22 0.36 1.9e-9 Diabetic retinopathy; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg23962285 chr1:108743536 SLC25A24 0.46 6.64 0.38 1.79e-10 Positive affect; CESC cis rs10789491 1.000 rs10789491 chr1:47179310 A/G cg15501359 chr1:47185051 KIAA0494 0.77 8.56 0.47 9.21e-16 Response to hepatitis C treatment; CESC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg18225595 chr11:63971243 STIP1 0.51 5.13 0.3 5.7e-7 Mean platelet volume; CESC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg03388025 chr16:89894329 SPIRE2 0.42 8.31 0.45 4.93e-15 Vitiligo; CESC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg24060327 chr5:131705240 SLC22A5 -0.77 -10.72 -0.55 1.68e-22 Breast cancer; CESC trans rs7615952 0.673 rs34209763 chr3:125599595 G/A cg07211511 chr3:129823064 LOC729375 -0.87 -8.83 -0.48 1.45e-16 Blood pressure (smoking interaction); CESC cis rs13418410 0.539 rs11677468 chr2:33839053 T/C cg04131969 chr2:33951647 MYADML -0.61 -7.37 -0.41 2.24e-12 Non-response to antidepressants and depression; CESC cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.1 0.3 6.4e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18836229 chr2:112655713 MERTK -0.5 -6.82 -0.39 5.97e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9788333 0.762 rs4441120 chr13:21886863 T/A cg06138931 chr13:21896616 NA 0.54 7.22 0.41 5.45e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs34366173 1 rs34366173 chr15:63998914 CTT/C cg12036633 chr15:63758958 NA -0.44 -5.22 -0.31 3.63e-7 Reticulocyte fraction of red cells; CESC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.7 0.38 1.22e-10 Bipolar disorder; CESC cis rs684232 0.666 rs838373 chr17:567171 T/C cg15660573 chr17:549704 VPS53 -0.64 -8.78 -0.47 2.09e-16 Prostate cancer; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg23283495 chr1:209979779 IRF6 0.63 11.92 0.59 1.69e-26 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg10691866 chr7:65817282 TPST1 0.32 5.36 0.31 1.8e-7 Aortic root size; CESC cis rs7264396 0.747 rs73283043 chr20:34383863 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.84 0.43 1.08e-13 Total cholesterol levels; CESC cis rs9291683 0.632 rs11734375 chr4:10046298 A/G cg00071950 chr4:10020882 SLC2A9 0.85 14.82 0.67 1.3e-36 Bone mineral density; CESC trans rs7819412 0.645 rs4841508 chr8:11065003 C/A cg15556689 chr8:8085844 FLJ10661 -0.54 -6.0 -0.35 6.53e-9 Triglycerides; CESC cis rs2637266 0.549 rs4633402 chr10:78414244 C/A cg18941641 chr10:78392320 NA -0.32 -5.25 -0.31 3.12e-7 Pulmonary function; CESC cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg02487422 chr3:49467188 NICN1 0.4 5.12 0.3 5.75e-7 Parkinson's disease; CESC cis rs561341 0.769 rs559228 chr17:30294527 T/C cg12193833 chr17:30244370 NA -0.71 -6.53 -0.37 3.38e-10 Hip circumference adjusted for BMI; CESC trans rs1373453 0.808 rs76680279 chr12:70073173 C/T cg19702771 chr4:82058885 PRKG2 0.74 6.01 0.35 6.27e-9 Orofacial clefts; CESC cis rs2997447 0.761 rs55815920 chr1:26457662 A/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.16 0.3 4.76e-7 QRS complex (12-leadsum); CESC cis rs6987853 0.814 rs1349471 chr8:42454011 C/T cg09913449 chr8:42400586 C8orf40 0.42 7.03 0.4 1.8e-11 Mean corpuscular hemoglobin concentration; CESC cis rs6964587 1.000 rs416 chr7:91580571 A/G cg17063962 chr7:91808500 NA -0.57 -7.62 -0.42 4.53e-13 Breast cancer; CESC cis rs6691722 0.583 rs7537875 chr1:24695151 A/T cg02336364 chr1:24764700 NIPAL3 0.28 6.02 0.35 5.94e-9 Response to interferon beta in multiple sclerosis; CESC cis rs2235642 0.891 rs2281231 chr16:1601879 A/G cg07639376 chr16:1584516 IFT140;TMEM204 -0.31 -5.06 -0.3 7.98e-7 Coronary artery disease; CESC cis rs6547741 1.000 rs10165098 chr2:27796526 C/T cg21248554 chr2:27665150 KRTCAP3 0.25 5.11 0.3 6.04e-7 Oral cavity cancer; CESC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg14926445 chr8:58193284 C8orf71 -0.54 -5.27 -0.31 2.78e-7 Developmental language disorder (linguistic errors); CESC cis rs1983891 0.553 rs3800283 chr6:41558358 A/G cg20194872 chr6:41519635 FOXP4 0.45 6.3 0.36 1.22e-9 Prostate cancer; CESC cis rs9549260 0.785 rs6563842 chr13:41244297 G/T cg21288729 chr13:41239152 FOXO1 0.68 8.52 0.46 1.24e-15 Red blood cell count; CESC cis rs9910055 0.552 rs12937114 chr17:42325073 A/G cg08499158 chr17:42289980 UBTF -0.49 -5.96 -0.34 7.87e-9 Total body bone mineral density; CESC cis rs6963495 0.818 rs73190133 chr7:105147821 G/C cg02135003 chr7:105160482 PUS7 -0.47 -5.61 -0.33 5.12e-8 Bipolar disorder (body mass index interaction); CESC cis rs2242194 0.844 rs11264295 chr1:154987526 C/T cg24250549 chr1:154909240 PMVK 0.41 5.27 0.31 2.79e-7 Schizophrenia; CESC cis rs8067354 0.831 rs2333617 chr17:57896220 T/A cg13753209 chr17:57696993 CLTC -0.52 -7.03 -0.4 1.71e-11 Hemoglobin concentration; CESC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg12648201 chr2:27665141 KRTCAP3 -0.36 -6.73 -0.38 1.07e-10 Total body bone mineral density; CESC cis rs5753618 0.504 rs5753671 chr22:31910734 T/C cg13145458 chr22:31556086 RNF185 -0.48 -5.69 -0.33 3.33e-8 Colorectal cancer; CESC cis rs9815354 0.812 rs56983571 chr3:41994473 T/C cg03022575 chr3:42003672 ULK4 0.67 5.88 0.34 1.23e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs2549003 1.000 rs7735073 chr5:131815357 G/A cg00255919 chr5:131827918 IRF1 0.51 8.71 0.47 3.26e-16 Asthma (sex interaction); CESC cis rs4865169 0.811 rs6841086 chr4:57903268 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.44 5.99 0.35 6.78e-9 Breast cancer; CESC cis rs2228479 0.850 rs11645916 chr16:89835234 G/A cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs7937682 0.889 rs516263 chr11:111484719 A/C cg22437258 chr11:111473054 SIK2 0.72 9.66 0.51 4.1e-19 Primary sclerosing cholangitis; CESC cis rs688020 1.000 rs688020 chr7:4228553 C/T cg24441899 chr7:4244372 SDK1 0.29 5.07 0.3 7.38e-7 Liver fibrosis in pediatric non-alcoholic fatty acid liver disease; CESC cis rs854765 0.619 rs6502636 chr17:17983817 A/T cg16928487 chr17:17741425 SREBF1 -0.52 -8.46 -0.46 1.8e-15 Total body bone mineral density; CESC cis rs2439831 0.850 rs60883262 chr15:44076503 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.7 6.73 0.38 1.02e-10 Lung cancer in ever smokers; CESC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -9.93 -0.52 5.93e-20 Alzheimer's disease; CESC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.51 6.93 0.39 3.15e-11 Lymphocyte counts; CESC trans rs61931739 0.534 rs1384860 chr12:34045388 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.22 0.41 5.44e-12 Morning vs. evening chronotype; CESC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9486719 1.000 rs2472887 chr6:96865437 A/G cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03749393 chr13:31191824 USPL1 -0.47 -6.23 -0.36 1.87e-9 Asthma; CESC cis rs524281 0.861 rs10896085 chr11:65913832 A/T cg14036092 chr11:66035641 RAB1B -0.58 -5.89 -0.34 1.17e-8 Electroencephalogram traits; CESC trans rs931812 0.895 rs13251731 chr8:101902528 C/G cg20993868 chr7:22813445 NA 0.56 8.27 0.45 6.58e-15 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.36 6.99 0.39 2.23e-11 Electroencephalogram traits; CESC cis rs2273669 0.667 rs12374597 chr6:109346184 A/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs13095912 0.962 rs7644758 chr3:185328197 G/T cg11274856 chr3:185301563 NA -0.35 -5.5 -0.32 8.96e-8 Systolic blood pressure; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14645085 chr6:13712693 RANBP9 -0.46 -6.19 -0.36 2.24e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg13866156 chr1:1669148 SLC35E2 -0.49 -6.31 -0.36 1.19e-9 Body mass index; CESC trans rs1450833 0.506 rs1194322 chr7:113884794 C/T cg23384340 chr11:57479802 MED19;TMX2 -0.49 -6.1 -0.35 3.76e-9 Neuroticism; CESC cis rs12497850 0.863 rs4858799 chr3:48728204 G/C cg03060546 chr3:49711283 APEH 0.45 5.63 0.33 4.68e-8 Parkinson's disease; CESC trans rs877282 0.628 rs11253435 chr10:824169 T/C cg22713356 chr15:30763199 NA 1.03 9.77 0.51 1.92e-19 Uric acid levels; CESC cis rs17376456 0.825 rs10038831 chr5:93124115 C/T cg21475434 chr5:93447410 FAM172A 0.8 7.22 0.41 5.48e-12 Diabetic retinopathy; CESC cis rs2197308 0.667 rs11181073 chr12:37898543 A/G cg26384229 chr12:38710491 ALG10B 0.67 9.61 0.51 6.07e-19 Morning vs. evening chronotype; CESC cis rs12477438 0.539 rs720228 chr2:99704547 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.03 0.68 2.4e-37 Chronic sinus infection; CESC trans rs9858542 0.903 rs35999162 chr3:49597230 C/G cg21659725 chr3:3221576 CRBN -0.52 -6.47 -0.37 4.72e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2535633 0.631 rs9823697 chr3:53002150 A/G cg11645453 chr3:52864694 ITIH4 0.27 5.06 0.3 8.01e-7 Body mass index; CESC cis rs1270639 0.778 rs1465250 chr7:157439075 C/G cg13357408 chr7:157437802 PTPRN2 0.6 6.95 0.39 2.8e-11 Colorectal cancer; CESC cis rs34375054 0.558 rs12578774 chr12:125681761 A/G cg05341575 chr12:125625032 AACS 0.36 5.25 0.31 3.2e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs3768617 0.811 rs12066082 chr1:183054863 G/C ch.1.3577855R chr1:183094577 LAMC1 0.66 9.17 0.49 1.37e-17 Fuchs's corneal dystrophy; CESC cis rs55788414 0.789 rs4630561 chr16:81183108 T/C cg06400318 chr16:81190750 PKD1L2 -0.57 -6.64 -0.38 1.79e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs748404 0.697 rs475227 chr15:43546446 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.51 8.01 0.44 3.59e-14 Lung cancer; CESC cis rs2820292 0.619 rs12562614 chr1:201814994 A/G cg11586189 chr1:201857591 SHISA4 -0.36 -5.83 -0.34 1.6e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs67478160 0.643 rs8004408 chr14:104203938 G/A cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.06 -0.4 1.43e-11 Schizophrenia; CESC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.59 0.38 2.36e-10 Bipolar disorder; CESC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg04287289 chr16:89883240 FANCA 0.92 16.16 0.7 2.38e-41 Vitiligo; CESC cis rs599083 0.530 rs491347 chr11:68169688 G/A cg01657329 chr11:68192670 LRP5 0.44 5.13 0.3 5.71e-7 Bone mineral density (spine); CESC trans rs116095464 0.558 rs10058428 chr5:235608 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.98 0.39 2.36e-11 Breast cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.5.389453F chr5:14788101 ANKH -0.43 -6.13 -0.35 3.18e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9611565 0.921 rs8137373 chr22:41729216 A/G cg06481639 chr22:41940642 POLR3H 0.57 6.12 0.35 3.3e-9 Vitiligo; CESC cis rs73110464 0.609 rs4919752 chr12:53359229 G/C cg05393297 chr12:53359155 NA -0.72 -10.44 -0.54 1.31e-21 Cancer (pleiotropy); CESC cis rs2635047 0.713 rs8086549 chr18:44756421 G/T cg24371990 chr18:44770781 NA -0.35 -5.61 -0.33 5.11e-8 Educational attainment; CESC cis rs75887402 1.000 rs73799308 chr5:122739242 T/C cg27033705 chr5:122759302 CEP120 0.81 5.54 0.32 7.3e-8 Breast cancer; CESC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.22 0.41 5.54e-12 Prudent dietary pattern; CESC cis rs7116495 1.000 rs12293885 chr11:71816092 T/A cg10381502 chr11:71823885 C11orf51 0.66 5.35 0.31 1.93e-7 Severe influenza A (H1N1) infection; CESC cis rs7829975 0.501 rs2980769 chr8:8320291 G/A cg06636001 chr8:8085503 FLJ10661 0.52 6.99 0.39 2.21e-11 Mood instability; CESC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.43e-7 Life satisfaction; CESC cis rs2075371 0.932 rs1862052 chr7:133981227 G/A cg20476274 chr7:133979776 SLC35B4 0.64 9.15 0.49 1.61e-17 Mean platelet volume; CESC cis rs11098499 0.954 rs66506550 chr4:120371445 T/A cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs5753618 0.561 rs2040533 chr22:31679110 G/C cg00478049 chr22:31556069 RNF185 0.44 5.04 0.3 8.82e-7 Colorectal cancer; CESC cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg26597838 chr10:835615 NA 0.85 9.27 0.49 6.87e-18 Eosinophil percentage of granulocytes; CESC cis rs34638657 0.732 rs62045963 chr16:82200661 A/G cg09439754 chr16:82129088 HSD17B2 -0.36 -6.24 -0.36 1.71e-9 Lung adenocarcinoma; CESC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg19622623 chr12:86230825 RASSF9 -0.47 -6.02 -0.35 5.87e-9 Major depressive disorder; CESC cis rs4728302 0.838 rs13231095 chr7:133604436 A/G cg10665199 chr7:133106180 EXOC4 0.4 5.56 0.32 6.62e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs6598955 0.694 rs6659387 chr1:26634307 G/A cg04990556 chr1:26633338 UBXN11 -0.79 -11.16 -0.57 5.72e-24 Obesity-related traits; CESC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6963495 0.745 rs56239334 chr7:105165351 G/A cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC trans rs11039798 0.591 rs74992349 chr11:49019252 G/A cg03929089 chr4:120376271 NA 0.61 6.01 0.35 6.02e-9 Axial length; CESC cis rs1707322 0.964 rs7546237 chr1:46285610 A/C cg06784218 chr1:46089804 CCDC17 0.31 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1814175 0.616 rs1794131 chr11:49904194 A/G cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.78 0.55 1.03e-22 Height; CESC cis rs637571 0.522 rs528736 chr11:65705108 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.44 5.41 0.32 1.39e-7 Eosinophil percentage of white cells; CESC cis rs5769707 0.521 rs739244 chr22:50060158 A/G cg05373962 chr22:49881684 NA -0.36 -5.58 -0.32 5.9e-8 Monocyte count;Monocyte percentage of white cells; CESC cis rs2832191 0.692 rs2245734 chr21:30359965 C/T cg24692254 chr21:30365293 RNF160 0.98 17.73 0.74 6.71e-47 Dental caries; CESC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg24585782 chr17:78113791 EIF4A3 -0.57 -7.53 -0.42 7.79e-13 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06747863 chr12:118810789 TAOK3 -0.45 -6.67 -0.38 1.52e-10 Gambling; CESC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 2e-7 Life satisfaction; CESC cis rs7246657 0.943 rs4801759 chr19:37954985 G/A cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs637571 0.544 rs500161 chr11:65695438 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.48 5.84 0.34 1.53e-8 Eosinophil percentage of white cells; CESC trans rs561341 1.000 rs693116 chr17:30246124 C/T cg27661571 chr11:113659931 NA -0.87 -7.9 -0.44 7.5e-14 Hip circumference adjusted for BMI; CESC cis rs2243480 0.901 rs2456483 chr7:65461575 T/C cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC cis rs9457247 0.602 rs9459854 chr6:167465882 C/T cg07741184 chr6:167504864 NA 0.37 6.49 0.37 4.2e-10 Crohn's disease; CESC trans rs10489896 0.588 rs10159244 chr1:234588171 C/T cg23817893 chr11:86085932 CCDC81 -0.45 -6.2 -0.36 2.14e-9 Cognitive test performance; CESC cis rs9303401 0.659 rs12948133 chr17:56673602 T/C cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.03 0.62 2.54e-30 Cognitive test performance; CESC trans rs17508449 0.819 rs17359281 chr1:114185959 C/T cg23028848 chr11:57092561 TNKS1BP1 0.74 6.16 0.35 2.73e-9 Leprosy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05881034 chr3:42623675 SEC22C -0.48 -6.37 -0.36 8.24e-10 Fibrinogen levels; CESC cis rs3126085 0.515 rs2275264 chr1:152331533 T/G cg03465714 chr1:152285911 FLG 0.4 5.15 0.3 5.16e-7 Atopic dermatitis; CESC cis rs7937682 0.924 rs513425 chr11:111504861 C/T cg22437258 chr11:111473054 SIK2 0.7 9.35 0.5 3.83e-18 Primary sclerosing cholangitis; CESC cis rs6701037 0.681 rs1057246 chr1:175127534 C/G cg00321850 chr1:175162397 KIAA0040 0.39 5.87 0.34 1.33e-8 Alcohol dependence; CESC trans rs55704346 0.566 rs4317194 chr4:25394477 T/C cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs11098499 0.908 rs1002152 chr4:120273387 C/A cg09307838 chr4:120376055 NA 0.94 13.05 0.63 2.15e-30 Corneal astigmatism; CESC cis rs2204008 0.653 rs11182569 chr12:38572452 G/A cg13010199 chr12:38710504 ALG10B 0.55 7.05 0.4 1.59e-11 Bladder cancer; CESC cis rs9916302 0.904 rs4794813 chr17:37670994 A/T cg07936489 chr17:37558343 FBXL20 -0.8 -11.19 -0.57 4.59e-24 Glomerular filtration rate (creatinine); CESC cis rs5771069 0.669 rs137879 chr22:50457041 C/T cg03721641 chr22:50451245 IL17REL 0.3 5.19 0.3 4.22e-7 Ulcerative colitis; CESC trans rs1814175 0.645 rs4598671 chr11:50003191 C/A cg15704280 chr7:45808275 SEPT13 -1.0 -18.49 -0.75 1.41e-49 Height; CESC cis rs9640161 0.830 rs3735165 chr7:150068371 T/C cg10018233 chr7:150070692 REPIN1 0.5 9.45 0.5 1.92e-18 Blood protein levels;Circulating chemerin levels; CESC cis rs863345 0.967 rs10797028 chr1:158523241 T/A cg12129480 chr1:158549410 OR10X1 -0.32 -6.43 -0.37 5.96e-10 Pneumococcal bacteremia; CESC cis rs1775715 0.707 rs1541262 chr10:32179771 A/G cg18675610 chr10:32216311 ARHGAP12 0.35 5.33 0.31 2.08e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg13393036 chr8:95962371 TP53INP1 -0.48 -10.6 -0.55 4.12e-22 Type 2 diabetes; CESC cis rs3768617 0.510 rs2296288 chr1:183072590 T/C ch.1.3577855R chr1:183094577 LAMC1 0.88 14.27 0.66 1.19e-34 Fuchs's corneal dystrophy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12268263 chr8:143359879 TSNARE1 0.44 6.48 0.37 4.49e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24132523 chr1:145827062 GPR89A -0.58 -6.85 -0.39 5.21e-11 Gut microbiome composition (summer); CESC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg12419862 chr22:24373484 LOC391322 -0.66 -7.78 -0.43 1.59e-13 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg23758822 chr17:41437982 NA 0.98 17.21 0.73 4.39e-45 Menopause (age at onset); CESC cis rs55882075 1.000 rs55882075 chr5:179210115 C/G cg14593053 chr5:179126677 CANX 0.42 5.58 0.32 5.84e-8 Monocyte percentage of white cells; CESC cis rs2236918 1.000 rs1776133 chr1:242025098 C/T cg17736920 chr1:242011382 EXO1 0.68 8.87 0.48 1.14e-16 Menopause (age at onset); CESC cis rs9457247 0.663 rs2237277 chr6:167442107 G/A cg07741184 chr6:167504864 NA 0.34 6.09 0.35 3.9e-9 Crohn's disease; CESC cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg14983838 chr19:29218262 NA 0.45 6.11 0.35 3.51e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs3749237 0.964 rs62260719 chr3:49852419 G/A cg03060546 chr3:49711283 APEH 0.61 7.07 0.4 1.41e-11 Resting heart rate; CESC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2228479 0.850 rs11076624 chr16:89855749 T/C cg14709524 chr16:89940631 TCF25 0.94 7.06 0.4 1.5e-11 Skin colour saturation; CESC cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg00409905 chr10:38381863 ZNF37A -0.51 -6.82 -0.39 6.22e-11 Extrinsic epigenetic age acceleration; CESC cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg23711669 chr6:146136114 FBXO30 0.96 13.94 0.65 1.74e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs2985684 1.000 rs8014170 chr14:50071694 C/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.46 -5.39 -0.31 1.55e-7 Carotid intima media thickness; CESC cis rs16854884 0.586 rs7639366 chr3:143752034 T/G cg06585982 chr3:143692056 C3orf58 0.51 6.92 0.39 3.46e-11 Economic and political preferences (feminism/equality); CESC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg03388025 chr16:89894329 SPIRE2 0.42 8.12 0.45 1.83e-14 Vitiligo; CESC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg03388025 chr16:89894329 SPIRE2 0.39 7.32 0.41 2.91e-12 Vitiligo; CESC cis rs9916302 0.784 rs4795361 chr17:37573446 G/A cg20243544 chr17:37824526 PNMT 0.5 6.37 0.36 8.48e-10 Glomerular filtration rate (creatinine); CESC cis rs3020736 0.500 rs2413669 chr22:42507748 A/C cg15557168 chr22:42548783 NA 0.45 6.51 0.37 3.78e-10 Autism spectrum disorder or schizophrenia; CESC cis rs12136530 0.774 rs12137162 chr1:19763396 G/T cg01832549 chr1:19774989 CAPZB -0.45 -6.5 -0.37 4.07e-10 Lead levels in blood; CESC cis rs34779708 0.649 rs34421369 chr10:35550275 G/C cg04310649 chr10:35416472 CREM -0.46 -5.2 -0.3 3.93e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs6964587 1.000 rs6951972 chr7:91689446 T/G cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.45e-15 Breast cancer; CESC cis rs6460942 0.822 rs13340498 chr7:12233877 G/T cg06484146 chr7:12443880 VWDE -0.46 -5.19 -0.3 4.09e-7 Coronary artery disease; CESC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg09359103 chr1:154839909 KCNN3 -0.65 -12.31 -0.6 7.76e-28 Prostate cancer; CESC cis rs7845219 0.544 rs6987400 chr8:95921295 T/C cg13393036 chr8:95962371 TP53INP1 -0.42 -7.77 -0.43 1.69e-13 Type 2 diabetes; CESC cis rs1003719 0.788 rs7275582 chr21:38451130 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.53 0.46 1.12e-15 Eye color traits; CESC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs72634258 0.645 rs59523164 chr1:7971827 G/A cg00042356 chr1:8021962 PARK7 0.83 7.54 0.42 7.31e-13 Inflammatory bowel disease; CESC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg02353165 chr6:42928485 GNMT 0.83 13.47 0.64 7.62e-32 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2625529 0.652 rs11634608 chr15:72255718 A/G cg16672083 chr15:72433130 SENP8 0.46 6.78 0.38 7.78e-11 Red blood cell count; CESC cis rs3126085 0.935 rs10749670 chr1:152220467 G/A cg03465714 chr1:152285911 FLG -0.45 -5.53 -0.32 7.55e-8 Atopic dermatitis; CESC cis rs7927771 0.698 rs34467936 chr11:47915299 A/G cg20307385 chr11:47447363 PSMC3 -0.44 -5.17 -0.3 4.55e-7 Subjective well-being; CESC cis rs9916302 0.680 rs2271308 chr17:37817482 T/C cg00129232 chr17:37814104 STARD3 -0.75 -10.14 -0.53 1.22e-20 Glomerular filtration rate (creatinine); CESC cis rs17253792 0.822 rs75049893 chr14:56089158 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.75 5.34 0.31 2.05e-7 Putamen volume; CESC cis rs1577917 0.874 rs11756621 chr6:86740063 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.13 -0.35 3.11e-9 Response to antipsychotic treatment; CESC cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.33 0.6 6.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs722599 0.748 rs731165 chr14:75352555 T/C cg08847533 chr14:75593920 NEK9 -0.45 -5.51 -0.32 8.52e-8 IgG glycosylation; CESC cis rs748404 0.578 rs4547312 chr15:43632138 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.59 9.34 0.5 4e-18 Lung cancer; CESC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg19717773 chr7:2847554 GNA12 -0.56 -8.13 -0.45 1.65e-14 Height; CESC cis rs4604732 0.603 rs4546958 chr1:247639478 G/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.46 6.5 0.37 3.87e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1506636 1.000 rs656425 chr7:123424525 A/C cg03229431 chr7:123269106 ASB15 0.49 6.54 0.37 3.11e-10 Plateletcrit;Platelet count; CESC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg17158414 chr2:27665306 KRTCAP3 -0.28 -5.09 -0.3 6.77e-7 Total body bone mineral density; CESC trans rs11088226 0.681 rs2833902 chr21:33940458 A/G cg09050820 chr6:167586206 TCP10L2 0.83 7.8 0.43 1.46e-13 Gastritis; CESC trans rs208520 1.000 rs12191403 chr6:66978137 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.33 0.5 4.5e-18 Exhaled nitric oxide output; CESC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg21248554 chr2:27665150 KRTCAP3 -0.37 -7.6 -0.42 4.99e-13 Total body bone mineral density; CESC cis rs6991838 0.584 rs1053087 chr8:66515865 A/G cg13398993 chr8:66546079 ARMC1 -0.46 -5.45 -0.32 1.14e-7 Intelligence (multi-trait analysis); CESC cis rs367615 0.680 rs385728 chr5:108966009 A/G cg17395555 chr5:108820864 NA -0.4 -5.52 -0.32 7.97e-8 Colorectal cancer (SNP x SNP interaction); CESC cis rs11734570 0.581 rs4461531 chr4:38603576 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.6 7.37 0.41 2.17e-12 Inflammatory bowel disease;Crohn's disease; CESC cis rs4919694 1.000 rs12254254 chr10:104765605 C/T cg04362960 chr10:104952993 NT5C2 0.74 6.35 0.36 9.25e-10 Arsenic metabolism; CESC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg17372223 chr3:52568218 NT5DC2 0.44 6.64 0.38 1.8e-10 Electroencephalogram traits; CESC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.94 0.59 1.43e-26 Alzheimer's disease; CESC cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.593 rs113184543 chr8:58042950 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -6.91 -0.39 3.62e-11 Developmental language disorder (linguistic errors); CESC cis rs1348850 0.567 rs3770012 chr2:178538023 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.56 -7.06 -0.4 1.48e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08077726 chr17:74734280 SFRS2;MFSD11 0.45 6.04 0.35 5.18e-9 Systemic lupus erythematosus; CESC cis rs6964587 0.867 rs12704637 chr7:91874686 C/T cg17063962 chr7:91808500 NA 0.51 6.12 0.35 3.3e-9 Breast cancer; CESC cis rs8141529 0.732 rs5752798 chr22:29181868 A/G cg15103426 chr22:29168792 CCDC117 0.7 9.85 0.52 1.06e-19 Lymphocyte counts; CESC cis rs7789940 0.951 rs7779014 chr7:75975586 C/T cg10167463 chr7:75959203 YWHAG -0.56 -7.09 -0.4 1.23e-11 Multiple sclerosis; CESC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg17143192 chr8:8559678 CLDN23 0.71 7.92 0.44 6.78e-14 Obesity-related traits; CESC cis rs9596863 1.000 rs7318666 chr13:54418960 C/G ch.13.53330881F chr13:54432880 NA -0.58 -5.08 -0.3 7.09e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg03709012 chr19:19516395 GATAD2A 0.99 15.8 0.7 4.37e-40 Tonsillectomy; CESC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg00074818 chr8:8560427 CLDN23 0.36 5.29 0.31 2.5e-7 Obesity-related traits; CESC cis rs1008375 1.000 rs4698198 chr4:17656536 G/A cg15017067 chr4:17643749 FAM184B 0.36 5.17 0.3 4.73e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4631830 0.900 rs7914347 chr10:51537431 C/T cg16070123 chr10:51489643 NA -0.34 -5.07 -0.3 7.4e-7 Prostate-specific antigen levels; CESC cis rs9287719 0.967 rs10203785 chr2:10752508 T/C cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs17666538 0.535 rs4338080 chr8:615598 A/G cg23958373 chr8:599963 NA 0.81 6.0 0.35 6.49e-9 IgG glycosylation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08882774 chr16:28875105 SH2B1 0.43 6.83 0.39 5.9e-11 Gambling; CESC cis rs4474465 0.646 rs10793335 chr11:78279005 C/G cg27205649 chr11:78285834 NARS2 0.48 6.26 0.36 1.51e-9 Alzheimer's disease (survival time); CESC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg16743903 chr16:89593216 SPG7 -0.39 -5.07 -0.3 7.37e-7 Multiple myeloma (IgH translocation); CESC cis rs2239547 0.657 rs2071040 chr3:52864860 A/G cg11645453 chr3:52864694 ITIH4 0.35 5.86 0.34 1.35e-8 Schizophrenia; CESC cis rs6540559 0.673 rs17015309 chr1:210007218 C/T cg25204440 chr1:209979598 IRF6 0.66 6.47 0.37 4.79e-10 Cleft lip with or without cleft palate; CESC cis rs11098499 0.913 rs67073020 chr4:120152557 C/T cg09307838 chr4:120376055 NA 0.87 11.37 0.57 1.21e-24 Corneal astigmatism; CESC cis rs6500602 0.627 rs841231 chr16:4583147 C/T cg08645402 chr16:4508243 NA -0.4 -6.01 -0.35 6.23e-9 Schizophrenia; CESC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.86 0.43 9.54e-14 Prudent dietary pattern; CESC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.66 -9.23 -0.49 8.97e-18 Prudent dietary pattern; CESC cis rs2243480 1.000 rs313807 chr7:65499481 C/T cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs12458462 0.859 rs34242155 chr18:77425192 G/A cg11879182 chr18:77439856 CTDP1 0.85 12.59 0.61 8.64e-29 Monocyte count; CESC cis rs17102884 0.506 rs4899540 chr14:75403408 G/A cg11812906 chr14:75593930 NEK9 -0.44 -5.41 -0.32 1.44e-7 Neuroticism; CESC cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg23711669 chr6:146136114 FBXO30 1.02 16.0 0.7 8.93e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs644799 0.544 rs498553 chr11:95534441 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.48 6.25 0.36 1.67e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7208859 0.673 rs12103759 chr17:29235687 G/A cg19761014 chr17:28927070 LRRC37B2 0.71 5.63 0.33 4.48e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9486719 1.000 rs4839837 chr6:96908706 G/A cg18709589 chr6:96969512 KIAA0776 0.48 5.7 0.33 3.19e-8 Migraine;Coronary artery disease; CESC cis rs9908102 0.740 rs4792309 chr17:12908204 T/C cg26162695 chr17:12921313 ELAC2 0.52 5.55 0.32 6.91e-8 Schizophrenia; CESC cis rs524281 0.861 rs10791858 chr11:65978396 A/G cg14036092 chr11:66035641 RAB1B -0.58 -5.92 -0.34 9.73e-9 Electroencephalogram traits; CESC cis rs6690583 0.623 rs61768852 chr1:85454613 T/C cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg24879335 chr3:133465180 TF -0.35 -6.29 -0.36 1.34e-9 Iron status biomarkers; CESC trans rs9906155 0.748 rs60104171 chr17:75669249 C/A cg14889768 chr6:146864529 RAB32 0.79 6.04 0.35 5.1e-9 Body mass index; CESC trans rs1493916 1.000 rs4799729 chr18:31393521 C/T cg27147174 chr7:100797783 AP1S1 0.52 7.02 0.4 1.81e-11 Life satisfaction; CESC cis rs9914578 1.000 rs8082647 chr17:2010597 C/T cg16513277 chr17:2031491 SMG6 0.62 7.1 0.4 1.16e-11 Body mass index; CESC cis rs425277 0.527 rs3107144 chr1:2045380 C/A cg24578937 chr1:2090814 PRKCZ -0.34 -6.01 -0.35 5.99e-9 Height; CESC trans rs4824093 0.610 rs73441745 chr22:50237606 G/A cg09872104 chr7:134855509 C7orf49 -0.99 -6.91 -0.39 3.58e-11 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9297145 0.565 rs6952161 chr7:98733337 A/G cg05967295 chr7:98741636 SMURF1 0.62 8.4 0.46 2.68e-15 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg02018176 chr4:1364513 KIAA1530 0.4 5.76 0.33 2.29e-8 Longevity; CESC cis rs7520050 1.000 rs785511 chr1:46534498 T/C cg03146154 chr1:46216737 IPP -0.44 -5.73 -0.33 2.78e-8 Red blood cell count;Reticulocyte count; CESC cis rs763121 0.819 rs138700 chr22:39129999 A/G cg21395723 chr22:39101663 GTPBP1 0.5 6.61 0.38 2.15e-10 Menopause (age at onset); CESC cis rs9790314 0.875 rs55688744 chr3:160944222 G/A cg03342759 chr3:160939853 NMD3 -0.54 -7.61 -0.42 4.69e-13 Morning vs. evening chronotype; CESC cis rs28830936 0.510 rs11858843 chr15:42092915 C/A cg17847044 chr15:42102381 MAPKBP1 -0.45 -7.89 -0.44 7.89e-14 Diastolic blood pressure; CESC cis rs2204008 0.715 rs11495369 chr12:38238673 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.52 1.51e-19 Bladder cancer; CESC cis rs9815354 1.000 rs9856633 chr3:42013850 C/T cg03022575 chr3:42003672 ULK4 0.43 5.03 0.3 9.16e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg02935154 chr7:12443704 VWDE -0.6 -6.57 -0.37 2.71e-10 Coronary artery disease; CESC cis rs11792861 1.000 rs11792861 chr9:111809295 A/C cg14384093 chr9:111878565 C9orf5 -0.42 -5.2 -0.3 3.91e-7 Menarche (age at onset); CESC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg16262614 chr3:133464971 TF 0.3 5.46 0.32 1.11e-7 Iron status biomarkers; CESC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg19626725 chr5:178986131 RUFY1 -0.42 -7.0 -0.4 2.09e-11 Lung cancer; CESC cis rs2742234 1.000 rs1864395 chr10:43655697 G/A cg07801480 chr10:43725741 RASGEF1A 0.4 5.75 0.33 2.5e-8 Hirschsprung disease; CESC cis rs1044826 0.642 rs432387 chr3:139231853 T/G cg00490450 chr3:139108681 COPB2 -0.45 -5.52 -0.32 7.99e-8 Obesity-related traits; CESC cis rs4237845 0.761 rs11172378 chr12:58298161 C/T cg00677455 chr12:58241039 CTDSP2 0.61 7.64 0.42 4.04e-13 Intelligence (multi-trait analysis); CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg01511534 chr16:3284640 ZNF200 0.63 6.82 0.39 6.09e-11 Diastolic blood pressure; CESC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg07507251 chr3:52567010 NT5DC2 -0.4 -6.96 -0.39 2.71e-11 Bipolar disorder; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10920302 chr3:45430089 LARS2 0.48 6.75 0.38 9.06e-11 Intelligence (multi-trait analysis); CESC cis rs11864453 1.000 rs2278027 chr16:72051369 A/G cg16558253 chr16:72132732 DHX38 -0.5 -7.21 -0.4 6e-12 Fibrinogen levels; CESC cis rs11122272 0.735 rs2244986 chr1:231537452 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -7.27 -0.41 4.07e-12 Hemoglobin concentration; CESC trans rs1814175 0.935 rs6485999 chr11:49658986 G/C cg15704280 chr7:45808275 SEPT13 -1.01 -17.87 -0.74 2.03e-47 Height; CESC cis rs9291683 0.632 rs7679916 chr4:10042160 C/T cg11266682 chr4:10021025 SLC2A9 0.67 13.02 0.62 2.72e-30 Bone mineral density; CESC cis rs9291683 0.546 rs13139055 chr4:10038924 G/T cg00071950 chr4:10020882 SLC2A9 0.82 13.72 0.64 9.99e-33 Bone mineral density; CESC cis rs2359239 0.519 rs8007145 chr14:75185748 T/A cg08847533 chr14:75593920 NEK9 0.47 5.71 0.33 3e-8 Neuroticism (multi-trait analysis); CESC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg25767906 chr1:53392781 SCP2 -0.44 -5.5 -0.32 8.72e-8 Monocyte count; CESC cis rs9470366 0.527 rs733590 chr6:36645203 A/G cg08179530 chr6:36648295 CDKN1A 0.67 10.05 0.53 2.49e-20 QRS duration; CESC cis rs4604732 0.588 rs9943231 chr1:247629829 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.52 6.38 0.36 7.89e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs36051895 0.664 rs17425819 chr9:5114773 C/T cg02405213 chr9:5042618 JAK2 -0.51 -6.07 -0.35 4.3e-9 Pediatric autoimmune diseases; CESC cis rs17376456 0.569 rs7736892 chr5:93205597 G/A cg25358565 chr5:93447407 FAM172A -0.7 -7.43 -0.42 1.45e-12 Diabetic retinopathy; CESC cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg13902645 chr11:5959945 NA -0.47 -5.59 -0.32 5.66e-8 DNA methylation (variation); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg03373518 chr20:54933821 C20orf108 -0.49 -6.66 -0.38 1.62e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs2832077 0.506 rs2832088 chr21:30158620 G/A cg08807101 chr21:30365312 RNF160 -0.45 -5.09 -0.3 6.91e-7 Cognitive test performance; CESC cis rs11098499 0.954 rs3733524 chr4:120423729 T/C cg24375607 chr4:120327624 NA 0.49 6.07 0.35 4.32e-9 Corneal astigmatism; CESC cis rs4803468 1.000 rs2231940 chr19:41944237 T/C cg08639244 chr19:41945921 ATP5SL 0.43 5.32 0.31 2.22e-7 Height; CESC cis rs6460942 0.597 rs4721107 chr7:12535105 T/G cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs7224737 1.000 rs7224737 chr17:40289364 A/G cg20291162 chr17:40259547 DHX58 0.43 5.76 0.33 2.32e-8 Fibrinogen levels; CESC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg21248554 chr2:27665150 KRTCAP3 -0.38 -7.9 -0.44 7.53e-14 Total body bone mineral density; CESC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg27535305 chr1:53392650 SCP2 0.31 5.47 0.32 1.02e-7 Monocyte count; CESC cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg07636037 chr3:49044803 WDR6 1.05 19.18 0.76 5.19e-52 Parkinson's disease; CESC cis rs7618915 0.501 rs55678971 chr3:52717229 T/A cg18337363 chr3:52569053 NT5DC2 0.3 5.39 0.31 1.54e-7 Bipolar disorder; CESC cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg25517755 chr10:38738941 LOC399744 -0.49 -6.35 -0.36 9.09e-10 Extrinsic epigenetic age acceleration; CESC cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg26408565 chr15:76604113 ETFA -0.43 -6.25 -0.36 1.65e-9 Blood metabolite levels; CESC cis rs3806843 0.735 rs2530235 chr5:140072647 G/T cg26395211 chr5:140044315 WDR55 0.46 5.91 0.34 1.03e-8 Depressive symptoms (multi-trait analysis); CESC trans rs11039798 0.844 rs11040177 chr11:48976211 G/C cg15704280 chr7:45808275 SEPT13 0.69 6.44 0.37 5.66e-10 Axial length; CESC cis rs5758659 0.714 rs5758578 chr22:42490292 A/C cg19513890 chr22:42538836 CYP2D7P1 0.37 5.52 0.32 7.95e-8 Cognitive function; CESC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg26668828 chr6:292823 DUSP22 -0.71 -9.56 -0.51 8.46e-19 Menopause (age at onset); CESC cis rs2073300 0.609 rs3736755 chr20:23377642 C/T cg12062639 chr20:23401060 NAPB 1.03 8.3 0.45 5.34e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.97 0.39 2.54e-11 Depression; CESC trans rs9325144 0.560 rs6582561 chr12:38666821 G/A cg23762105 chr12:34175262 ALG10 0.48 6.31 0.36 1.15e-9 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18551660 chr20:50769044 ZFP64 -0.56 -6.3 -0.36 1.2e-9 Gut microbiome composition (summer); CESC cis rs8060686 0.641 rs76646352 chr16:68044797 C/A cg26727032 chr16:67993705 SLC12A4 -0.54 -6.15 -0.35 2.78e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs796364 0.760 rs56225698 chr2:200910653 A/C cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC cis rs9532580 0.620 rs2701859 chr13:41141232 T/C cg21288729 chr13:41239152 FOXO1 0.67 7.9 0.44 7.31e-14 Mean corpuscular hemoglobin; CESC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg12463550 chr7:65579703 CRCP -0.45 -5.72 -0.33 2.86e-8 Aortic root size; CESC cis rs7923609 0.967 rs4486511 chr10:65264266 C/T cg01631684 chr10:65280961 REEP3 -0.43 -5.4 -0.31 1.47e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.46 0.46 1.8e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6445797 0.632 rs9881005 chr3:56604425 A/T cg13792233 chr3:56591045 CCDC66 0.39 5.11 0.3 6.18e-7 Gastritis; CESC cis rs4233802 0.737 rs74749038 chr2:151177761 G/A cg25300694 chr2:151184358 NA -0.95 -7.19 -0.4 6.55e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg16325326 chr1:53192061 ZYG11B -0.7 -11.18 -0.57 5.14e-24 Monocyte count; CESC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.91 -0.52 6.75e-20 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10822447 chr10:70748436 KIAA1279 -0.6 -6.81 -0.39 6.63e-11 Gut microbiome composition (summer); CESC trans rs561341 0.941 rs7215147 chr17:30266711 G/A cg20587970 chr11:113659929 NA -0.84 -10.79 -0.55 9.49e-23 Hip circumference adjusted for BMI; CESC cis rs78456975 1.000 rs10189336 chr2:1558015 G/A cg01028140 chr2:1542097 TPO -0.54 -5.65 -0.33 4.12e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7799006 0.606 rs12535174 chr7:2310974 C/T cg12745145 chr7:2261452 MAD1L1 -0.33 -5.25 -0.31 3.14e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9611565 0.559 rs132768 chr22:42013523 C/A cg06634786 chr22:41940651 POLR3H 0.61 6.13 0.35 3.21e-9 Vitiligo; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg15990800 chr14:55738852 FBXO34 0.57 7.52 0.42 8.46e-13 Attention deficit hyperactivity disorder; CESC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg23172400 chr8:95962367 TP53INP1 -0.46 -9.61 -0.51 5.95e-19 Type 2 diabetes; CESC cis rs6831352 1.000 rs10017466 chr4:100055800 C/T cg12011299 chr4:100065546 ADH4 0.68 8.63 0.47 5.75e-16 Alcohol dependence; CESC trans rs9858542 1.000 rs13316695 chr3:49684917 C/G cg21659725 chr3:3221576 CRBN -0.53 -6.49 -0.37 4.09e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs34638657 0.732 rs11859473 chr16:82201072 T/C cg09439754 chr16:82129088 HSD17B2 -0.36 -6.24 -0.36 1.71e-9 Lung adenocarcinoma; CESC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg11987759 chr7:65425863 GUSB 0.47 6.51 0.37 3.68e-10 Aortic root size; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg27588646 chr5:72469145 TMEM174 -0.44 -6.32 -0.36 1.08e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 5.35 0.31 1.9e-7 Menopause (age at onset); CESC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg11905131 chr22:24372483 LOC391322 0.65 9.19 0.49 1.19e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs62103177 0.673 rs4438371 chr18:77615988 C/T cg05926928 chr17:57297772 GDPD1 0.77 7.96 0.44 5.07e-14 Opioid sensitivity; CESC cis rs9858542 1.000 rs11130213 chr3:49712297 C/T cg07274523 chr3:49395745 GPX1 0.66 8.53 0.46 1.13e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs854765 0.583 rs11656840 chr17:17837354 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.28 0.41 3.7e-12 Total body bone mineral density; CESC cis rs3105593 1.000 rs12442787 chr15:50918107 G/T cg08437265 chr15:50716283 USP8 0.4 5.13 0.3 5.69e-7 QT interval; CESC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg22920501 chr2:26401640 FAM59B -0.78 -9.21 -0.49 1.03e-17 Gut microbiome composition (summer); CESC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg13206674 chr6:150067644 NUP43 0.41 5.85 0.34 1.46e-8 Lung cancer; CESC cis rs18122 0.881 rs7585530 chr2:67618256 C/T cg09028215 chr2:67624308 ETAA1 -0.44 -5.26 -0.31 3.01e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs75229567 0.618 rs78294090 chr12:70209959 G/T cg10114359 chr12:70132523 RAB3IP 1.16 7.31 0.41 3.11e-12 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13639345 chr22:39052718 CBY1;LOC646851 -0.55 -6.14 -0.35 2.96e-9 Gut microbiome composition (summer); CESC trans rs1728785 1.000 rs4783656 chr16:68580722 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs7165102 1.000 rs11636148 chr15:65796880 C/T cg11441148 chr15:65824328 PTPLAD1 -0.32 -5.31 -0.31 2.32e-7 Mean corpuscular hemoglobin; CESC cis rs8078723 1.000 rs4794824 chr17:38179290 G/A cg17467752 chr17:38218738 THRA 0.69 10.73 0.55 1.52e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs6952809 0.532 rs2057840 chr7:2432797 C/G cg25507518 chr7:2405875 EIF3B 0.45 5.03 0.3 8.93e-7 Multiple sclerosis; CESC trans rs1814175 0.817 rs10839401 chr11:49876144 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.86 -0.77 2.27e-54 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15356780 chr14:90422831 TDP1 0.47 6.13 0.35 3.19e-9 Gut microbiota (bacterial taxa); CESC cis rs1878931 0.555 rs27228 chr16:3431933 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.76 -8.67 -0.47 4.35e-16 Body mass index (adult); CESC cis rs3820928 1.000 rs10197757 chr2:227763244 A/C cg05526886 chr2:227700861 RHBDD1 -0.41 -5.33 -0.31 2.09e-7 Pulmonary function; CESC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg09365446 chr1:150670422 GOLPH3L -0.42 -5.87 -0.34 1.27e-8 Tonsillectomy; CESC cis rs933688 0.652 rs4916856 chr5:90596403 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.52 -6.22 -0.36 1.89e-9 Smoking behavior; CESC cis rs2599510 0.811 rs2583713 chr2:32822729 A/G cg02381751 chr2:32503542 YIPF4 0.5 6.16 0.35 2.62e-9 Interleukin-18 levels; CESC cis rs6429082 0.627 rs2016437 chr1:235539355 T/G cg26050004 chr1:235667680 B3GALNT2 -0.54 -6.76 -0.38 8.92e-11 Adiposity; CESC trans rs561341 0.941 rs8066558 chr17:30272879 G/T cg27661571 chr11:113659931 NA -0.68 -6.86 -0.39 4.92e-11 Hip circumference adjusted for BMI; CESC trans rs4950322 0.518 rs56151278 chr1:146589003 T/C cg04954894 chr8:38089920 DDHD2 -0.59 -6.34 -0.36 9.74e-10 Protein quantitative trait loci; CESC cis rs8180040 1.000 rs553989 chr3:47400328 A/G cg27129171 chr3:47204927 SETD2 -0.66 -10.43 -0.54 1.43e-21 Colorectal cancer; CESC cis rs727563 0.520 rs132773 chr22:42031768 T/A cg06634786 chr22:41940651 POLR3H 0.59 6.01 0.35 6.19e-9 Crohn's disease;Inflammatory bowel disease; CESC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg22968622 chr17:43663579 NA 1.32 18.29 0.75 6.72e-49 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11098499 0.818 rs55825515 chr4:120486402 A/G cg09307838 chr4:120376055 NA 0.91 12.65 0.61 5.08e-29 Corneal astigmatism; CESC cis rs2479724 0.840 rs10498752 chr6:41768510 T/C cg17623882 chr6:41773611 USP49 0.42 5.8 0.34 1.87e-8 Menarche (age at onset); CESC cis rs8067545 0.532 rs67217337 chr17:20236432 C/T cg13482628 chr17:19912719 NA -0.41 -5.22 -0.31 3.61e-7 Schizophrenia; CESC cis rs9325144 0.600 rs1825807 chr12:38737007 T/C cg26384229 chr12:38710491 ALG10B 0.55 7.79 0.43 1.53e-13 Morning vs. evening chronotype; CESC trans rs1814175 0.587 rs847628 chr11:49927064 A/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs7402982 0.625 rs4966008 chr15:99203445 A/G cg03437748 chr15:99193247 IGF1R -0.61 -8.08 -0.44 2.26e-14 Birth weight; CESC trans rs11039798 0.614 rs11039954 chr11:48741818 A/G cg15704280 chr7:45808275 SEPT13 0.7 6.42 0.37 6.38e-10 Axial length; CESC cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg05340658 chr4:99064831 C4orf37 0.84 13.04 0.63 2.35e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3820928 0.605 rs13410141 chr2:227805529 A/G cg11843606 chr2:227700838 RHBDD1 -0.56 -7.97 -0.44 4.7e-14 Pulmonary function; CESC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.23 -0.31 3.48e-7 Obesity-related traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18194353 chr1:100315666 AGL -0.46 -6.75 -0.38 9.22e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs73019876 0.805 rs2522106 chr19:22140621 T/A cg11619707 chr19:22235551 ZNF257 -0.27 -5.11 -0.3 6.12e-7 Testicular germ cell tumor; CESC cis rs11098499 0.779 rs7674500 chr4:120303593 C/T cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02149193 chr12:132512069 EP400 -0.59 -6.57 -0.37 2.72e-10 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg10691866 chr7:65817282 TPST1 0.31 5.09 0.3 6.78e-7 Aortic root size; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg22647065 chr19:19612767 GATAD2A 0.48 6.02 0.35 5.64e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg24250549 chr1:154909240 PMVK 0.75 11.19 0.57 4.57e-24 Prostate cancer; CESC cis rs7191439 0.584 rs7193436 chr16:88748736 T/C cg27087555 chr16:88793112 FAM38A -1.03 -6.22 -0.36 1.94e-9 Plateletcrit; CESC cis rs637571 0.544 rs12361552 chr11:65701204 G/A cg26695010 chr11:65641043 EFEMP2 0.44 5.49 0.32 9.2e-8 Eosinophil percentage of white cells; CESC cis rs8067545 0.578 rs4925087 chr17:20024582 A/C cg13482628 chr17:19912719 NA 0.4 5.35 0.31 1.86e-7 Schizophrenia; CESC cis rs10911232 0.507 rs6664995 chr1:183017345 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 13.5 0.64 5.78e-32 Hypertriglyceridemia; CESC cis rs7949030 0.590 rs12225213 chr11:62350248 T/A cg11742103 chr11:62369870 EML3;MTA2 0.67 10.01 0.52 3.28e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.42 5.18 0.3 4.38e-7 Eosinophil percentage of white cells; CESC cis rs9911578 0.935 rs117819974 chr17:57002324 C/T cg05425664 chr17:57184151 TRIM37 -0.51 -7.05 -0.4 1.52e-11 Intelligence (multi-trait analysis); CESC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg16606324 chr3:10149918 C3orf24 -0.42 -5.37 -0.31 1.76e-7 Alzheimer's disease; CESC cis rs1008375 1.000 rs4698651 chr4:17694223 A/G cg02297831 chr4:17616191 MED28 0.47 5.72 0.33 2.91e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9399135 0.967 rs1590975 chr6:135352088 C/T cg22676075 chr6:135203613 NA 0.49 6.97 0.39 2.45e-11 Red blood cell count; CESC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4132509 0.739 rs79367267 chr1:243689543 C/A cg21452805 chr1:244014465 NA 0.58 6.23 0.36 1.8e-9 RR interval (heart rate); CESC cis rs644799 0.965 rs573758 chr11:95539591 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9346455 1.000 rs9342828 chr6:71993657 T/C cg27238071 chr6:71998145 OGFRL1 0.56 5.08 0.3 7e-7 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs12995491 0.933 rs13008732 chr2:88528771 G/A cg18490616 chr2:88469792 THNSL2 -0.53 -7.9 -0.44 7.33e-14 Response to metformin (IC50); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19524972 chr12:121647936 P2RX4 0.56 6.2 0.36 2.16e-9 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg04450456 chr4:17643702 FAM184B 0.38 5.35 0.31 1.95e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs2571521 0.887 rs9298879 chr9:26097224 A/C cg27287808 chr1:45266048 PLK3 0.76 6.1 0.35 3.76e-9 Pursuit maintenance gain in psychotic disorders; CESC cis rs7914558 0.899 rs7913682 chr10:104684392 T/A cg15744005 chr10:104629667 AS3MT -0.36 -5.57 -0.32 6.31e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.47e-7 Life satisfaction; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg07051796 chr16:72982538 ZFHX3 0.44 6.18 0.35 2.43e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs265548 0.646 rs36692 chr19:17906839 C/T cg04517722 chr19:17905589 B3GNT3 0.43 5.78 0.33 2.12e-8 Tumor biomarkers; CESC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg09699651 chr6:150184138 LRP11 0.4 5.1 0.3 6.46e-7 Lung cancer; CESC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg21984481 chr17:79567631 NPLOC4 -0.33 -5.17 -0.3 4.68e-7 Eye color traits; CESC cis rs62103177 0.810 rs62103175 chr18:77622467 C/T cg12964065 chr18:77638022 KCNG2 0.57 5.41 0.32 1.4e-7 Opioid sensitivity; CESC cis rs977987 0.864 rs37595 chr16:75496963 G/C cg03315344 chr16:75512273 CHST6 -0.46 -6.48 -0.37 4.48e-10 Dupuytren's disease; CESC cis rs4481887 0.927 rs6689193 chr1:248482900 T/A cg00666640 chr1:248458726 OR2T12 0.36 6.07 0.35 4.47e-9 Common traits (Other); CESC cis rs6752107 0.967 rs12162308 chr2:234172188 C/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.86 0.39 4.91e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs2243480 0.901 rs2456483 chr7:65461575 T/C cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC cis rs7267979 1.000 rs2297497 chr20:25297909 C/T cg08601574 chr20:25228251 PYGB -0.39 -5.57 -0.32 6.21e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs28386778 0.965 rs2854154 chr17:61981696 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.04 -18.01 -0.74 6.5e-48 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11387077 chr7:30544503 GGCT 0.56 6.58 0.37 2.49e-10 Gut microbiome composition (summer); CESC cis rs67478160 0.654 rs1997913 chr14:104213960 C/T cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.01 -0.4 1.98e-11 Schizophrenia; CESC cis rs863345 0.604 rs10797012 chr1:158465485 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -7.03 -0.4 1.78e-11 Pneumococcal bacteremia; CESC cis rs7666738 0.719 rs35184673 chr4:99050945 T/C cg05340658 chr4:99064831 C4orf37 0.56 5.76 0.33 2.31e-8 Colonoscopy-negative controls vs population controls; CESC cis rs524281 0.814 rs1055615 chr11:65846922 C/G cg14036092 chr11:66035641 RAB1B -0.55 -5.85 -0.34 1.45e-8 Electroencephalogram traits; CESC cis rs2455799 0.593 rs2062823 chr3:15732256 G/T cg16303742 chr3:15540471 COLQ -0.38 -5.92 -0.34 9.86e-9 Mean platelet volume; CESC cis rs6690583 0.623 rs12041012 chr1:85515644 G/A cg22488158 chr1:85528044 WDR63 0.57 5.51 0.32 8.47e-8 Serum sulfate level; CESC cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg03709012 chr19:19516395 GATAD2A -0.98 -14.29 -0.66 1.02e-34 Tonsillectomy; CESC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg24562669 chr7:97807699 LMTK2 0.52 7.64 0.42 3.99e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs2075371 0.547 rs12666682 chr7:134021784 C/A cg20476274 chr7:133979776 SLC35B4 0.51 6.7 0.38 1.26e-10 Mean platelet volume; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg07911682 chr1:51425659 FAF1 -0.47 -6.53 -0.37 3.39e-10 Recombination measurement; CESC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg18876405 chr7:65276391 NA 0.5 6.68 0.38 1.43e-10 Aortic root size; CESC cis rs7927592 0.763 rs7129248 chr11:68263276 A/T cg16797656 chr11:68205561 LRP5 0.47 7.17 0.4 7.54e-12 Total body bone mineral density; CESC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg24562669 chr7:97807699 LMTK2 0.47 6.74 0.38 9.62e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg20756934 chr12:56510353 RPL41 0.54 6.12 0.35 3.33e-9 Psoriatic arthritis; CESC cis rs1568889 1.000 rs7949057 chr11:28255053 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.82 11.78 0.59 4.79e-26 Bipolar disorder; CESC cis rs2988277 0.713 rs10800313 chr1:167429985 C/T cg09179987 chr1:167433047 CD247 -0.35 -5.21 -0.31 3.73e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg11301795 chr4:187892539 NA -0.76 -12.44 -0.61 2.73e-28 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25276849 chr3:195808919 TFRC -0.43 -6.23 -0.36 1.78e-9 Gambling; CESC cis rs4409675 0.527 rs1884469 chr1:28239434 G/A cg23691781 chr1:28212827 C1orf38 0.28 5.48 0.32 1.01e-7 Corneal astigmatism; CESC cis rs559928 0.606 rs55942618 chr11:63936005 C/T cg18225595 chr11:63971243 STIP1 0.69 6.22 0.36 1.88e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs6963495 0.745 rs73192151 chr7:105211876 A/G cg02135003 chr7:105160482 PUS7 -0.48 -5.51 -0.32 8.52e-8 Bipolar disorder (body mass index interaction); CESC cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg20503657 chr10:835505 NA -0.7 -6.61 -0.38 2.12e-10 Eosinophil percentage of granulocytes; CESC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg19500275 chr17:80737654 TBCD 0.46 5.28 0.31 2.68e-7 Glycated hemoglobin levels; CESC cis rs116095464 0.558 rs55664502 chr5:270485 T/C cg10591111 chr5:226296 SDHA -0.51 -6.24 -0.36 1.71e-9 Breast cancer; CESC cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg01448562 chr3:133502909 NA -0.48 -6.41 -0.37 6.74e-10 Iron status biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05614267 chr16:69373129 NIP7;COG8 0.61 7.66 0.43 3.59e-13 Gut microbiome composition (summer); CESC cis rs1801251 1.000 rs283468 chr2:233658309 C/T cg25237894 chr2:233734115 C2orf82 0.46 8.02 0.44 3.47e-14 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19345149 chr11:116658875 ZNF259 -0.48 -6.02 -0.35 5.93e-9 Ulcerative colitis; CESC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg07414643 chr4:187882934 NA 0.56 8.14 0.45 1.53e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs2732480 0.500 rs7966829 chr12:48615603 G/T cg04545296 chr12:48745243 ZNF641 0.39 6.45 0.37 5.34e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6800768 0.633 rs6807599 chr3:24145588 A/C cg10674438 chr3:24145617 LOC152024 -0.44 -6.11 -0.35 3.49e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.42 -0.32 1.35e-7 Total body bone mineral density; CESC cis rs12142240 0.698 rs72677592 chr1:46818288 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs3008870 0.755 rs2208577 chr1:67513574 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.55 6.75 0.38 9.11e-11 Lymphocyte percentage of white cells; CESC cis rs6815814 0.950 rs73236632 chr4:38836071 G/A cg02016764 chr4:38805732 TLR1 -0.61 -6.79 -0.38 7.42e-11 Breast cancer; CESC cis rs10751667 0.643 rs10902245 chr11:953014 C/T cg06064525 chr11:970664 AP2A2 0.51 9.99 0.52 3.63e-20 Alzheimer's disease (late onset); CESC cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg26597838 chr10:835615 NA 0.81 8.67 0.47 4.32e-16 Eosinophil percentage of granulocytes; CESC cis rs9905704 0.918 rs68139131 chr17:56717249 A/G cg12560992 chr17:57184187 TRIM37 0.59 6.98 0.39 2.34e-11 Testicular germ cell tumor; CESC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg27121462 chr16:89883253 FANCA 0.78 11.75 0.59 6.03e-26 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12122961 chr3:197355151 LOC220729 0.54 6.12 0.35 3.33e-9 Gut microbiome composition (summer); CESC cis rs7917772 0.503 rs7914389 chr10:104295402 T/C cg22532475 chr10:104410764 TRIM8 -0.34 -5.81 -0.34 1.82e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.56 0.58 2.62e-25 Platelet count; CESC cis rs250677 1.000 rs250677 chr5:148433549 T/C cg18129178 chr5:148520854 ABLIM3 -0.45 -5.31 -0.31 2.31e-7 Breast cancer; CESC cis rs752010 0.967 rs2038978 chr1:42094719 A/G cg06885757 chr1:42089581 HIVEP3 0.49 8.07 0.44 2.48e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9660992 1.000 rs9660992 chr1:205249450 A/G cg21643547 chr1:205240462 TMCC2 -0.44 -7.09 -0.4 1.24e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs2243480 1.000 rs313814 chr7:65503293 C/A cg12463550 chr7:65579703 CRCP 0.69 5.41 0.32 1.39e-7 Diabetic kidney disease; CESC cis rs7130144 0.686 rs12288732 chr11:130434267 A/G cg26307797 chr11:130446613 NA -0.59 -5.42 -0.32 1.31e-7 Urate levels in lean individuals; CESC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.54 7.1 0.4 1.17e-11 Lymphocyte counts; CESC cis rs9790314 1.000 rs336585 chr3:161081670 A/G cg03342759 chr3:160939853 NMD3 -0.47 -6.05 -0.35 4.83e-9 Morning vs. evening chronotype; CESC cis rs7312933 0.670 rs10880269 chr12:42606135 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.51 0.37 3.8e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22368307 chr11:75110460 SNORD15A;RPS3 -0.44 -6.16 -0.35 2.74e-9 Gut microbiota (bacterial taxa); CESC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg00166722 chr3:10149974 C3orf24 0.45 5.67 0.33 3.82e-8 Alzheimer's disease; CESC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg25767906 chr1:53392781 SCP2 -0.39 -5.07 -0.3 7.31e-7 Monocyte count; CESC cis rs7208859 0.623 rs216445 chr17:28933576 A/G cg13385521 chr17:29058706 SUZ12P 0.77 5.67 0.33 3.8e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg14159672 chr1:205819179 PM20D1 0.89 15.28 0.68 3.25e-38 Menarche (age at onset); CESC trans rs7980799 0.649 rs7972688 chr12:33653477 T/C cg26384229 chr12:38710491 ALG10B -0.57 -7.96 -0.44 5.02e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg10691866 chr7:65817282 TPST1 -0.32 -5.15 -0.3 5.14e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07823935 chr2:183902842 NCKAP1 -0.69 -7.89 -0.44 7.99e-14 Gut microbiome composition (summer); CESC cis rs3824867 1.000 rs3824867 chr11:47468569 A/G cg20307385 chr11:47447363 PSMC3 0.51 6.27 0.36 1.43e-9 Mean corpuscular hemoglobin; CESC cis rs9625935 0.518 rs245008 chr22:30315736 T/C cg01021169 chr22:30184971 ASCC2 -0.44 -6.87 -0.39 4.46e-11 Tonsillectomy; CESC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg02038168 chr22:39784481 NA 0.62 7.95 0.44 5.37e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1178968 0.818 rs2262777 chr7:72786490 A/T cg25889504 chr7:72793014 NA 0.49 5.18 0.3 4.46e-7 Triglyceride levels; CESC cis rs7584330 0.868 rs13386290 chr2:238393136 G/C cg14458575 chr2:238380390 NA 0.71 9.71 0.51 2.79e-19 Prostate cancer; CESC trans rs629535 0.814 rs56326813 chr8:70107736 T/A cg21567404 chr3:27674614 NA -0.87 -10.05 -0.53 2.43e-20 Dupuytren's disease; CESC cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.77 -12.76 -0.62 2.17e-29 Personality dimensions; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg10808102 chr17:25783956 NA 0.4 6.11 0.35 3.6e-9 Vertical cup-disc ratio; CESC cis rs4704187 0.687 rs1477937 chr5:74524837 A/G cg03227963 chr5:74354835 NA 0.28 5.13 0.3 5.48e-7 Response to amphetamines; CESC cis rs2797160 1.000 rs4895798 chr6:126000162 A/G cg05901451 chr6:126070800 HEY2 -0.45 -6.67 -0.38 1.44e-10 Endometrial cancer; CESC cis rs4077515 0.527 rs10870146 chr9:139308054 G/A cg14169450 chr9:139327907 INPP5E 0.52 7.82 0.43 1.22e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs854765 0.647 rs854814 chr17:18003648 G/A cg04398451 chr17:18023971 MYO15A -0.78 -11.51 -0.58 3.94e-25 Total body bone mineral density; CESC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.72 0.33 2.9e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7923609 1.000 rs4400684 chr10:65012687 A/G cg01631684 chr10:65280961 REEP3 -0.44 -5.48 -0.32 9.99e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs1670533 1.000 rs11731320 chr4:1057916 T/A cg27284194 chr4:1044797 NA 0.48 6.06 0.35 4.7e-9 Recombination rate (females); CESC cis rs28374715 0.532 rs28463309 chr15:41666716 A/G cg20272979 chr15:41787780 ITPKA 0.43 5.39 0.31 1.59e-7 Ulcerative colitis; CESC cis rs654950 0.841 rs2810549 chr1:41991761 C/T cg06885757 chr1:42089581 HIVEP3 -0.44 -6.75 -0.38 9.38e-11 Airway imaging phenotypes; CESC cis rs1801251 1.000 rs11676216 chr2:233706368 C/T cg08000102 chr2:233561755 GIGYF2 -0.7 -10.11 -0.53 1.51e-20 Coronary artery disease; CESC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg11941060 chr3:133502564 NA -0.44 -5.84 -0.34 1.56e-8 Iron status biomarkers; CESC cis rs7149242 0.922 rs9671394 chr14:101159674 C/T cg18089426 chr14:101175970 NA -0.36 -5.91 -0.34 1.07e-8 Platelet count; CESC cis rs963731 0.649 rs10779924 chr2:39208057 G/T cg04010122 chr2:39346883 SOS1 -0.68 -5.11 -0.3 6.11e-7 Corticobasal degeneration; CESC cis rs12530845 1.000 rs12540325 chr7:135334111 T/C cg23117316 chr7:135346802 PL-5283 -0.43 -5.38 -0.31 1.61e-7 Red blood cell traits; CESC trans rs11098499 0.691 rs9307471 chr4:120261262 G/A cg25214090 chr10:38739885 LOC399744 0.61 8.68 0.47 4.06e-16 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05139649 chr11:108368923 KDELC2 0.54 6.34 0.36 9.6e-10 Gut microbiome composition (summer); CESC cis rs8078723 0.690 rs56326707 chr17:38130139 C/T cg17467752 chr17:38218738 THRA 0.57 8.43 0.46 2.28e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09041756 chr7:5570314 ACTB -0.5 -6.3 -0.36 1.21e-9 Ulcerative colitis; CESC cis rs55692411 0.537 rs13071931 chr3:50062878 G/A cg24308560 chr3:49941425 MST1R -0.53 -6.52 -0.37 3.51e-10 Intelligence (multi-trait analysis); CESC cis rs9682041 0.696 rs6798399 chr3:170086482 G/A cg11886554 chr3:170076028 SKIL 0.7 6.49 0.37 4.1e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC trans rs4455778 0.579 rs10265045 chr7:49131824 G/T cg25315252 chr10:81839033 LOC219347;C10orf57 -0.41 -6.09 -0.35 3.92e-9 Lung cancer in never smokers; CESC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg08470875 chr2:26401718 FAM59B -0.47 -5.29 -0.31 2.56e-7 Gut microbiome composition (summer); CESC cis rs6963495 0.818 rs73192124 chr7:105171528 C/T cg19920283 chr7:105172520 RINT1 0.68 6.44 0.37 5.53e-10 Bipolar disorder (body mass index interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03093995 chr9:114393414 DNAJC25-GNG10;DNAJC25 -0.5 -7.14 -0.4 8.79e-12 Gambling; CESC cis rs950169 0.887 rs35986397 chr15:84955107 G/A cg17507749 chr15:85114479 UBE2QP1 0.6 6.56 0.37 2.82e-10 Schizophrenia; CESC cis rs9948 0.655 rs75763821 chr2:97392694 G/A cg01990225 chr2:97406019 LMAN2L -1.02 -7.78 -0.43 1.58e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg22920501 chr2:26401640 FAM59B -0.67 -8.02 -0.44 3.47e-14 Gut microbiome composition (summer); CESC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg11663144 chr21:46675770 NA -0.59 -9.01 -0.48 4.07e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg26939375 chr7:64535504 NA -0.75 -10.73 -0.55 1.52e-22 Aortic root size; CESC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg11941060 chr3:133502564 NA 0.52 7.03 0.4 1.78e-11 Iron status biomarkers; CESC cis rs35110281 0.720 rs230647 chr21:44919654 C/T cg01579765 chr21:45077557 HSF2BP 0.54 8.49 0.46 1.52e-15 Mean corpuscular volume; CESC cis rs17431357 1.000 rs73225208 chr12:120932576 G/A cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs6964587 1.000 rs2188154 chr7:91595138 T/A cg17063962 chr7:91808500 NA 0.57 7.82 0.43 1.22e-13 Breast cancer; CESC cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg03467027 chr4:99064603 C4orf37 0.43 5.21 0.3 3.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9649465 0.967 rs10269196 chr7:123321073 G/T cg04330084 chr7:123175371 IQUB -0.38 -5.2 -0.3 3.94e-7 Migraine; CESC cis rs9303401 0.614 rs28687626 chr17:57191904 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.99 11.18 0.57 5e-24 Cognitive test performance; CESC cis rs7116495 0.609 rs1894004 chr11:71759817 G/A cg18441811 chr11:71824068 C11orf51 -0.83 -5.34 -0.31 1.98e-7 Severe influenza A (H1N1) infection; CESC cis rs738322 0.967 rs4380 chr22:38569529 T/C cg25457927 chr22:38595422 NA -0.3 -5.57 -0.32 6.3e-8 Cutaneous nevi; CESC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.09 19.2 0.76 4.43e-52 Height; CESC cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg05585544 chr11:47624801 NA -0.52 -8.03 -0.44 3.23e-14 Subjective well-being; CESC cis rs2228479 0.850 rs62056091 chr16:89930414 G/A cg06558623 chr16:89946397 TCF25 1.17 8.95 0.48 6.17e-17 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02632185 chr5:66299786 MAST4 -0.57 -6.02 -0.35 5.84e-9 Gut microbiome composition (summer); CESC trans rs459571 0.959 rs2810491 chr9:136923331 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 0.65 8.49 0.46 1.53e-15 Platelet distribution width; CESC cis rs2463822 0.669 rs72919496 chr11:62052730 T/C cg06239285 chr11:62104954 ASRGL1 -1.12 -8.88 -0.48 1.03e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04730839 chr6:42985884 KLHDC3 0.45 6.73 0.38 1.04e-10 Gut microbiota (bacterial taxa); CESC cis rs1215050 0.740 rs783938 chr4:99010336 A/T cg17366294 chr4:99064904 C4orf37 -0.39 -5.12 -0.3 5.98e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs72829446 0.530 rs4796424 chr17:7387973 T/C cg02795151 chr17:7402630 POLR2A 0.55 5.86 0.34 1.41e-8 Androgen levels; CESC cis rs4243830 0.737 rs4908923 chr1:6614535 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.79 -8.22 -0.45 8.87e-15 Body mass index; CESC cis rs6991838 0.557 rs57419568 chr8:66510868 G/A cg13398993 chr8:66546079 ARMC1 -0.47 -5.59 -0.32 5.56e-8 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13581475 chr14:64854533 MTHFD1 0.46 6.28 0.36 1.39e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg26939375 chr7:64535504 NA 0.76 10.79 0.55 9.56e-23 Calcium levels; CESC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg04518342 chr5:131593106 PDLIM4 0.41 6.2 0.36 2.1e-9 Breast cancer; CESC cis rs9399135 0.967 rs952674 chr6:135349157 A/G cg24558204 chr6:135376177 HBS1L 0.52 7.29 0.41 3.48e-12 Red blood cell count; CESC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg18404041 chr3:52824283 ITIH1 -0.49 -8.1 -0.45 2.08e-14 Bipolar disorder; CESC cis rs763121 0.853 rs5757200 chr22:39043491 T/G cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs7727544 0.645 rs272857 chr5:131685297 G/A cg24060327 chr5:131705240 SLC22A5 -0.6 -7.77 -0.43 1.74e-13 Blood metabolite levels; CESC trans rs17764205 0.852 rs10412307 chr19:3251994 C/T cg22364819 chr2:127864926 BIN1 0.63 6.05 0.35 4.81e-9 Bipolar disorder and schizophrenia; CESC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg25019033 chr10:957182 NA -0.59 -6.35 -0.36 9.39e-10 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19402173 chr7:128379420 CALU 0.58 6.24 0.36 1.7e-9 Gut microbiome composition (summer); CESC cis rs709400 1.000 rs55885592 chr14:104126024 C/T cg12935359 chr14:103987150 CKB -0.45 -6.08 -0.35 4.23e-9 Body mass index; CESC cis rs9790314 1.000 rs6765269 chr3:160948542 T/C cg03342759 chr3:160939853 NMD3 -0.45 -5.73 -0.33 2.78e-8 Morning vs. evening chronotype; CESC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -6.93 -0.39 3.2e-11 Bipolar disorder; CESC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg26338869 chr17:61819248 STRADA 0.66 8.6 0.47 7.02e-16 Prudent dietary pattern; CESC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg10691866 chr7:65817282 TPST1 0.32 5.4 0.31 1.49e-7 Aortic root size; CESC cis rs2235642 0.928 rs9932984 chr16:1605051 A/G cg07639376 chr16:1584516 IFT140;TMEM204 -0.32 -5.27 -0.31 2.86e-7 Coronary artery disease; CESC cis rs1790761 0.587 rs4930431 chr11:67294308 C/T cg08355456 chr11:67383691 NA -0.34 -5.47 -0.32 1.03e-7 Mean corpuscular volume; CESC cis rs920590 0.758 rs1907799 chr8:19664668 A/G cg17834443 chr8:19674713 INTS10 -0.53 -6.23 -0.36 1.87e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg08736216 chr1:53307985 ZYG11A 0.39 6.32 0.36 1.12e-9 Monocyte count; CESC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg06634786 chr22:41940651 POLR3H -0.7 -7.21 -0.4 5.83e-12 Vitiligo; CESC cis rs7395581 0.918 rs3781622 chr11:47348702 T/C cg25783544 chr11:47291846 MADD 0.6 7.79 0.43 1.49e-13 HDL cholesterol; CESC cis rs1983891 0.955 rs9381076 chr6:41517564 G/A cg20194872 chr6:41519635 FOXP4 0.59 8.45 0.46 1.9e-15 Prostate cancer; CESC cis rs959260 1.000 rs2033609 chr17:73367021 C/T cg20590849 chr17:73267439 MIF4GD -0.55 -6.4 -0.37 6.95e-10 Systemic lupus erythematosus; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05640069 chr1:94312038 MIR760 -0.48 -6.01 -0.35 5.96e-9 Ulcerative colitis; CESC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg18876405 chr7:65276391 NA -0.51 -7.03 -0.4 1.8e-11 Aortic root size; CESC cis rs4478858 0.735 rs2889730 chr1:31827159 C/T cg00250761 chr1:31883323 NA -0.26 -5.07 -0.3 7.56e-7 Alcohol dependence; CESC cis rs644799 1.000 rs568668 chr11:95528209 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.84 0.65 3.87e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg21963583 chr11:68658836 MRPL21 0.4 5.52 0.32 8.06e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4588572 0.644 rs6870646 chr5:77741082 G/A cg11547950 chr5:77652471 NA -0.4 -5.56 -0.32 6.42e-8 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04107082 chr2:61245442 PEX13;PUS10 0.66 7.79 0.43 1.54e-13 Gut microbiome composition (summer); CESC trans rs5758511 0.773 rs9623482 chr22:42360574 T/C cg15080870 chr19:47770746 CCDC9 0.51 6.27 0.36 1.45e-9 Birth weight; CESC cis rs477692 0.673 rs1970197 chr10:131359588 C/T cg24747557 chr10:131355152 MGMT -0.38 -5.17 -0.3 4.55e-7 Response to temozolomide; CESC cis rs2797685 1.000 rs697691 chr1:7885354 A/G cg04725166 chr1:7887271 PER3 -0.45 -6.26 -0.36 1.55e-9 Crohn's disease; CESC cis rs10465746 0.933 rs2224990 chr1:84436275 C/A cg10977910 chr1:84465055 TTLL7 0.47 6.32 0.36 1.13e-9 Obesity-related traits; CESC cis rs2637266 0.714 rs4475870 chr10:78450724 T/A cg18941641 chr10:78392320 NA 0.43 7.78 0.43 1.68e-13 Pulmonary function; CESC cis rs12145833 0.596 rs12026068 chr1:243440352 A/G cg02356786 chr1:243265016 LOC731275 0.75 5.66 0.33 3.99e-8 Obesity (early onset extreme); CESC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg24562669 chr7:97807699 LMTK2 0.48 6.92 0.39 3.3e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs11098499 0.909 rs28793658 chr4:120307214 A/C cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs5758511 0.680 rs1001586 chr22:42670293 G/T cg00645731 chr22:42541494 CYP2D7P1 0.58 8.66 0.47 4.81e-16 Birth weight; CESC cis rs9486719 0.857 rs4486027 chr6:96911886 T/C cg06623918 chr6:96969491 KIAA0776 -0.79 -9.15 -0.49 1.55e-17 Migraine;Coronary artery disease; CESC cis rs12618769 0.597 rs3754881 chr2:99132093 G/A cg10123293 chr2:99228465 UNC50 0.41 5.44 0.32 1.24e-7 Bipolar disorder; CESC cis rs698833 0.562 rs13402006 chr2:44726040 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.41 5.16 0.3 4.84e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7590368 0.673 rs55648622 chr2:10932765 C/T cg15705551 chr2:10952987 PDIA6 0.55 5.26 0.31 2.96e-7 Educational attainment (years of education); CESC cis rs9549367 0.789 rs9549716 chr13:113908478 G/A cg00898013 chr13:113819073 PROZ -0.52 -7.45 -0.42 1.31e-12 Platelet distribution width; CESC cis rs2243480 1.000 rs11538349 chr7:65421871 C/T cg12463550 chr7:65579703 CRCP 0.66 5.61 0.33 4.98e-8 Diabetic kidney disease; CESC cis rs3733585 0.673 rs6836706 chr4:9964251 T/A cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7267979 0.966 rs2424715 chr20:25420077 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 3.04e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs9443189 0.813 rs3798439 chr6:76566734 T/G cg01950844 chr6:76311363 SENP6 -0.58 -6.13 -0.35 3.2e-9 Prostate cancer; CESC cis rs7216064 0.953 rs80135947 chr17:65836001 A/C cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.73e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11122272 0.766 rs2790867 chr1:231548059 A/C cg06096015 chr1:231504339 EGLN1 -0.41 -5.78 -0.33 2.13e-8 Hemoglobin concentration; CESC cis rs11583043 0.793 rs3903905 chr1:101420957 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.55 6.12 0.35 3.39e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs7584330 0.738 rs4402703 chr2:238374957 T/A cg14458575 chr2:238380390 NA 0.62 8.3 0.45 5.37e-15 Prostate cancer; CESC cis rs9811920 0.683 rs10936003 chr3:99667565 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -6.38 -0.37 7.68e-10 Axial length; CESC trans rs877282 0.898 rs11253339 chr10:759640 C/T cg22713356 chr15:30763199 NA 1.15 11.38 0.57 1.05e-24 Uric acid levels; CESC cis rs963731 0.649 rs12620071 chr2:39345873 G/A cg04010122 chr2:39346883 SOS1 0.73 5.17 0.3 4.6e-7 Corticobasal degeneration; CESC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg11890956 chr21:40555474 PSMG1 -0.62 -8.69 -0.47 3.94e-16 Menarche (age at onset); CESC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg27286337 chr10:134555280 INPP5A 0.68 7.7 0.43 2.8e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg19077165 chr18:44547161 KATNAL2 -0.53 -7.79 -0.43 1.54e-13 Personality dimensions; CESC cis rs80130819 0.748 rs2634679 chr12:48735304 G/T cg05342945 chr12:48394962 COL2A1 -0.53 -5.6 -0.33 5.26e-8 Prostate cancer; CESC cis rs9314323 0.729 rs7823021 chr8:26224958 G/T cg11498726 chr8:26250323 BNIP3L -0.46 -6.5 -0.37 3.89e-10 Red cell distribution width; CESC cis rs9549367 0.789 rs3764124 chr13:113897320 C/T cg00898013 chr13:113819073 PROZ -0.54 -7.22 -0.41 5.39e-12 Platelet distribution width; CESC cis rs5769765 0.865 rs10854860 chr22:50320029 G/T cg26441486 chr22:50317300 CRELD2 0.48 5.78 0.33 2.08e-8 Schizophrenia; CESC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg21782813 chr7:2030301 MAD1L1 0.49 7.04 0.4 1.68e-11 Bipolar disorder and schizophrenia; CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg10819733 chr22:24237672 NA 0.51 7.44 0.42 1.39e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9611565 0.592 rs5758406 chr22:42076641 A/G cg03806693 chr22:41940476 POLR3H 1.01 11.96 0.59 1.19e-26 Vitiligo; CESC cis rs11997175 0.656 rs2350007 chr8:33585353 C/G ch.8.33884649F chr8:33765107 NA 0.5 6.59 0.38 2.4e-10 Body mass index; CESC cis rs1552244 0.554 rs3732965 chr3:10048760 A/C cg00149659 chr3:10157352 C3orf10 0.54 6.63 0.38 1.89e-10 Alzheimer's disease; CESC cis rs1577917 0.958 rs72907388 chr6:86440207 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -7.24 -0.41 4.9e-12 Response to antipsychotic treatment; CESC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg05132306 chr1:1846340 CALML6 -0.29 -5.81 -0.34 1.77e-8 Body mass index; CESC cis rs2832077 0.689 rs2832055 chr21:30132382 C/G cg24692254 chr21:30365293 RNF160 0.48 5.78 0.33 2.06e-8 Cognitive test performance; CESC cis rs6547741 1.000 rs6547741 chr2:27855924 G/A cg27432699 chr2:27873401 GPN1 0.46 6.43 0.37 5.87e-10 Oral cavity cancer; CESC cis rs9300255 0.602 rs4372492 chr12:123697357 T/C cg05973401 chr12:123451056 ABCB9 0.49 5.63 0.33 4.63e-8 Neutrophil percentage of white cells; CESC cis rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01386335 chr7:17704951 NA 0.43 5.87 0.34 1.33e-8 Fibrinogen levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16236679 chr11:96123321 JRKL;CCDC82 -0.47 -6.59 -0.38 2.38e-10 Gut microbiota (bacterial taxa); CESC cis rs4253772 0.575 rs9615956 chr22:46749634 C/T cg18190219 chr22:46762943 CELSR1 -0.74 -6.46 -0.37 4.98e-10 LDL cholesterol;Cholesterol, total; CESC cis rs12476592 0.516 rs6734648 chr2:63801525 A/G cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs5769765 0.778 rs8137331 chr22:50313358 G/C cg02269571 chr22:50332266 NA -0.55 -7.09 -0.4 1.22e-11 Schizophrenia; CESC cis rs11048434 0.636 rs11614970 chr12:9060053 G/A cg04155231 chr12:9217510 LOC144571 0.31 5.06 0.3 8.03e-7 Sjögren's syndrome; CESC cis rs1153858 1.000 rs7181167 chr15:45686236 C/G cg21132104 chr15:45694354 SPATA5L1 0.86 11.67 0.58 1.14e-25 Homoarginine levels; CESC cis rs9399137 0.507 rs11758774 chr6:135383789 T/G cg24558204 chr6:135376177 HBS1L 0.7 9.59 0.51 6.85e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg05555928 chr11:63887634 MACROD1 0.62 9.65 0.51 4.37e-19 Platelet count; CESC cis rs9815354 0.767 rs73077390 chr3:41860255 T/C cg03022575 chr3:42003672 ULK4 0.66 5.8 0.34 1.87e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs72945132 0.882 rs6592537 chr11:70172975 C/T cg14191688 chr11:70257035 CTTN 0.43 5.46 0.32 1.11e-7 Coronary artery disease; CESC cis rs4835473 0.932 rs1511425 chr4:144906275 C/T cg25736465 chr4:144833511 NA 0.41 6.29 0.36 1.28e-9 Immature fraction of reticulocytes; CESC cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg24308560 chr3:49941425 MST1R -0.57 -8.18 -0.45 1.19e-14 Body mass index; CESC cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg00033643 chr7:134001901 SLC35B4 0.4 5.03 0.3 9.11e-7 Mean platelet volume; CESC cis rs2708240 1.000 rs2538977 chr7:147584571 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.33 -5.33 -0.31 2.06e-7 QT interval (drug interaction); CESC cis rs71277158 0.688 rs9757709 chr3:169906407 T/G cg04067573 chr3:169899625 PHC3 0.7 6.72 0.38 1.09e-10 Prostate cancer; CESC cis rs11252926 0.537 rs61836851 chr10:447231 T/C cg03684893 chr10:554711 DIP2C -0.35 -5.1 -0.3 6.52e-7 Psychosis in Alzheimer's disease; CESC cis rs7149337 0.837 rs10132658 chr14:51677599 C/T cg23942311 chr14:51606299 NA 0.43 7.12 0.4 1e-11 Cancer; CESC cis rs7617773 0.539 rs11130165 chr3:48384721 G/T cg11946769 chr3:48343235 NME6 0.66 8.34 0.46 4.12e-15 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01213445 chr15:91537450 PRC1 -0.5 -6.14 -0.35 3.05e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09695362 chr17:43324895 LOC100133991 0.59 6.54 0.37 3.24e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08536481 chr12:123459152 ABCB9;OGFOD2 0.65 7.92 0.44 6.4e-14 Gut microbiome composition (summer); CESC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg05234568 chr11:5960015 NA -0.66 -9.75 -0.51 2.12e-19 DNA methylation (variation); CESC cis rs9362426 0.708 rs4707365 chr6:88100912 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.51 6.16 0.35 2.75e-9 Depressive episodes in bipolar disorder; CESC cis rs6088590 1.000 rs6120750 chr20:33465289 A/C cg24642439 chr20:33292090 TP53INP2 0.88 12.03 0.59 6.64e-27 Coronary artery disease; CESC trans rs5769765 0.825 rs7511620 chr22:50307932 T/C cg09872104 chr7:134855509 C7orf49 -0.55 -6.22 -0.36 1.9e-9 Schizophrenia; CESC cis rs80130819 0.748 rs2732440 chr12:48660429 G/A cg05342945 chr12:48394962 COL2A1 -0.48 -5.23 -0.31 3.4e-7 Prostate cancer; CESC cis rs6543140 0.929 rs6742530 chr2:103082280 G/A cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs6674176 0.597 rs6671164 chr1:44403489 G/T cg15962314 chr1:44399869 ARTN 0.27 5.06 0.3 7.66e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6500602 0.964 rs62039173 chr16:4463846 G/A cg08645402 chr16:4508243 NA 0.46 7.02 0.4 1.88e-11 Schizophrenia; CESC trans rs11098499 0.866 rs72676074 chr4:120359841 A/C cg25214090 chr10:38739885 LOC399744 0.71 10.0 0.52 3.37e-20 Corneal astigmatism; CESC cis rs6688613 0.649 rs2280995 chr1:166846069 A/G cg07049167 chr1:166818506 POGK 0.44 5.07 0.3 7.32e-7 Refractive astigmatism; CESC cis rs290268 0.874 rs290991 chr9:93561450 A/C cg02608019 chr9:93564028 SYK -0.6 -9.8 -0.52 1.53e-19 Platelet count; CESC cis rs710865 0.723 rs710870 chr1:19549759 G/A cg13387374 chr1:19411106 UBR4 0.49 6.47 0.37 4.6e-10 Brain structure; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15291980 chr2:36441749 NA -0.45 -6.28 -0.36 1.41e-9 Systemic lupus erythematosus; CESC cis rs668210 0.947 rs610497 chr11:65765551 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.74 9.23 0.49 9.03e-18 Cerebrospinal fluid biomarker levels; CESC cis rs910316 1.000 rs3742780 chr14:75505008 G/C cg08847533 chr14:75593920 NEK9 0.99 17.95 0.74 1.1e-47 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14170117 chr10:126490218 FAM175B -0.47 -6.26 -0.36 1.52e-9 Fibrinogen levels; CESC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.95 10.43 0.54 1.45e-21 Mean platelet volume; CESC cis rs7267979 1.000 rs2500446 chr20:25339664 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -16.6 -0.71 6.43e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg24308560 chr3:49941425 MST1R -0.62 -8.93 -0.48 7.32e-17 Intelligence (multi-trait analysis); CESC trans rs17685 0.753 rs2302435 chr7:75676987 G/A cg19862616 chr7:65841803 NCRNA00174 -0.86 -12.65 -0.61 4.99e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs4820539 1.000 rs5759598 chr22:23480962 T/G cg14186256 chr22:23484241 RTDR1 0.79 13.6 0.64 2.55e-32 Bone mineral density; CESC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.83 -9.25 -0.49 7.55e-18 Gut microbiome composition (summer); CESC cis rs910316 0.737 rs175077 chr14:75506875 G/A cg16144293 chr14:75469539 EIF2B2 0.39 5.1 0.3 6.55e-7 Height; CESC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg25072359 chr17:41440525 NA 0.43 5.82 0.34 1.68e-8 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10029411 chr13:50746245 FAM10A4 -0.65 -8.09 -0.45 2.11e-14 Gut microbiome composition (summer); CESC cis rs4423214 1.000 rs4944959 chr11:71168234 C/T cg05163923 chr11:71159392 DHCR7 -0.81 -11.25 -0.57 2.83e-24 Vitamin D levels; CESC cis rs2228479 0.850 rs2302162 chr16:89845287 A/G cg06558623 chr16:89946397 TCF25 1.16 9.23 0.49 8.91e-18 Skin colour saturation; CESC cis rs2832077 0.527 rs2776210 chr21:30268558 A/G cg24692254 chr21:30365293 RNF160 0.66 8.89 0.48 9.41e-17 Cognitive test performance; CESC cis rs870825 0.616 rs10025167 chr4:185649551 A/C cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg18876405 chr7:65276391 NA -0.5 -6.92 -0.39 3.36e-11 Aortic root size; CESC cis rs7666738 0.546 rs34159897 chr4:98787367 T/C cg17366294 chr4:99064904 C4orf37 0.52 6.61 0.38 2.09e-10 Colonoscopy-negative controls vs population controls; CESC cis rs2730245 0.527 rs2527194 chr7:158732959 G/A cg24397884 chr7:158709396 WDR60 -0.86 -9.02 -0.48 3.88e-17 Height; CESC cis rs870825 0.587 rs6826883 chr4:185616167 A/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs9584850 0.834 rs3803253 chr13:99117149 G/A cg20750642 chr13:99100586 FARP1 -0.4 -6.02 -0.35 5.8e-9 Neuroticism; CESC cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg20090143 chr19:45452003 APOC2 -0.34 -5.48 -0.32 9.95e-8 Blood protein levels; CESC cis rs10861342 1.000 rs10861346 chr12:105473245 G/T cg23923672 chr12:105501055 KIAA1033 0.7 5.53 0.32 7.7e-8 IgG glycosylation; CESC trans rs61931739 0.534 rs11053131 chr12:34282109 A/G cg26384229 chr12:38710491 ALG10B 0.45 6.12 0.35 3.28e-9 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23611233 chr1:249133059 ZNF672 0.6 6.64 0.38 1.73e-10 Gut microbiome composition (summer); CESC cis rs72781680 0.898 rs718139 chr2:23975911 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.76 0.38 8.82e-11 Lymphocyte counts; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25746746 chr12:109531439 ALKBH2 -0.46 -6.39 -0.37 7.4e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4660306 1.000 rs11211132 chr1:45990516 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.72 -0.43 2.33e-13 Homocysteine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27607583 chr16:3767744 TRAP1 0.57 6.47 0.37 4.66e-10 Gut microbiome composition (summer); CESC cis rs17021463 0.617 rs35368920 chr4:95325588 C/T cg11021082 chr4:95130006 SMARCAD1 0.46 6.08 0.35 4.23e-9 Testicular germ cell tumor; CESC cis rs858239 0.665 rs858306 chr7:23242754 A/T cg23682824 chr7:23144976 KLHL7 0.44 5.99 0.35 6.76e-9 Cerebrospinal fluid biomarker levels; CESC cis rs10089 0.953 rs2016015 chr5:127527253 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.02 0.52 2.96e-20 Ileal carcinoids; CESC cis rs1538970 0.962 rs9429076 chr1:45819489 A/G cg24296786 chr1:45957014 TESK2 -0.48 -5.58 -0.32 5.96e-8 Platelet count; CESC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.76 0.33 2.3e-8 Menopause (age at onset); CESC cis rs10493773 0.609 rs12097932 chr1:86182216 A/G cg17807903 chr1:86174739 ZNHIT6 -0.44 -6.5 -0.37 3.98e-10 Urate levels in overweight individuals; CESC cis rs9623117 0.915 rs28837144 chr22:40461508 T/C cg05033341 chr22:40419857 FAM83F -0.47 -5.33 -0.31 2.13e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs9910055 0.529 rs575798 chr17:42181796 A/C cg19774624 chr17:42201019 HDAC5 0.58 7.65 0.43 3.73e-13 Total body bone mineral density; CESC cis rs12042052 1.000 rs12042052 chr1:232935719 C/T cg06935979 chr1:232941706 KIAA1383 -0.73 -5.97 -0.34 7.61e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14019672 chr1:145507353 RBM8A 0.44 6.19 0.36 2.25e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9902453 0.817 rs67206808 chr17:28190096 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.26 0.45 7.02e-15 Coffee consumption (cups per day); CESC cis rs1801251 0.963 rs13424351 chr2:233573629 A/G cg08000102 chr2:233561755 GIGYF2 0.64 8.5 0.46 1.38e-15 Coronary artery disease; CESC cis rs2228479 0.717 rs11649210 chr16:89807233 C/G cg06558623 chr16:89946397 TCF25 0.77 7.2 0.4 6.07e-12 Skin colour saturation; CESC cis rs2011503 1.000 rs11671253 chr19:19604206 C/T cg11584989 chr19:19387371 SF4 0.62 7.13 0.4 9.66e-12 Bipolar disorder; CESC cis rs67311347 1.000 rs6762997 chr3:40478151 C/T cg24209194 chr3:40518798 ZNF619 0.49 6.52 0.37 3.55e-10 Renal cell carcinoma; CESC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.11e-8 Alzheimer's disease; CESC cis rs10504229 0.906 rs7846666 chr8:58172302 T/C cg22535103 chr8:58192502 C8orf71 -0.87 -11.35 -0.57 1.38e-24 Developmental language disorder (linguistic errors); CESC cis rs2249625 0.526 rs17781511 chr6:72845455 C/T cg18830697 chr6:72922368 RIMS1 0.43 6.23 0.36 1.81e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg22875332 chr1:76189707 ACADM -0.5 -5.35 -0.31 1.86e-7 Blood metabolite levels;Acylcarnitine levels; CESC cis rs67478160 0.679 rs8011109 chr14:104279974 G/A cg08213375 chr14:104286397 PPP1R13B 0.54 10.69 0.55 2.07e-22 Schizophrenia; CESC cis rs7191439 0.790 rs2306046 chr16:88781419 A/G cg02389323 chr16:88786976 FAM38A 0.87 7.46 0.42 1.27e-12 Plateletcrit; CESC cis rs7247513 0.930 rs35275129 chr19:12716493 G/A cg11738485 chr19:12877000 HOOK2 0.41 5.06 0.3 7.98e-7 Bipolar disorder; CESC cis rs4595586 0.545 rs1156707 chr12:39372451 G/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs208520 0.690 rs12208310 chr6:66730108 G/C cg07460842 chr6:66804631 NA 0.96 12.77 0.62 2e-29 Exhaled nitric oxide output; CESC cis rs7772486 0.875 rs2748497 chr6:146319417 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.55 0.37 3.05e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg02574844 chr11:5959923 NA -0.42 -5.29 -0.31 2.52e-7 DNA methylation (variation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05126138 chr4:83821944 THAP9 0.6 6.95 0.39 2.87e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05523449 chr17:8396080 MYH10 -0.59 -6.34 -0.36 9.78e-10 Gut microbiome composition (summer); CESC cis rs4555082 0.957 rs2735818 chr14:105714751 A/G cg10792982 chr14:105748885 BRF1 0.4 5.52 0.32 7.87e-8 Mean platelet volume;Platelet distribution width; CESC cis rs965469 0.779 rs2207994 chr20:3294304 C/T cg25506879 chr20:3388711 C20orf194 -0.48 -5.35 -0.31 1.92e-7 IFN-related cytopenia; CESC cis rs2549003 1.000 rs3846732 chr5:131816087 T/C cg00255919 chr5:131827918 IRF1 0.51 8.57 0.47 8.55e-16 Asthma (sex interaction); CESC cis rs9291683 0.551 rs2240720 chr4:10020480 C/T cg02734326 chr4:10020555 SLC2A9 0.52 7.49 0.42 9.99e-13 Bone mineral density; CESC cis rs4975709 0.838 rs4975753 chr5:1880865 T/C cg12288994 chr5:1860383 NA 0.37 5.92 0.34 1.02e-8 Cardiovascular disease risk factors; CESC cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.78 7.89 0.44 7.93e-14 Schizophrenia; CESC cis rs734999 0.505 rs10797438 chr1:2540262 C/T cg20673091 chr1:2541236 MMEL1 0.45 7.87 0.44 9.22e-14 Ulcerative colitis; CESC cis rs6831352 0.819 rs13832 chr4:99993075 C/A cg13256891 chr4:100009986 ADH5 0.7 8.27 0.45 6.71e-15 Alcohol dependence; CESC cis rs3820928 0.874 rs4675138 chr2:227884118 G/A cg11843606 chr2:227700838 RHBDD1 -0.45 -5.84 -0.34 1.56e-8 Pulmonary function; CESC cis rs12220238 1.000 rs11000888 chr10:75901929 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.52 0.37 3.45e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs4481887 0.927 rs4409694 chr1:248485498 C/T cg00666640 chr1:248458726 OR2T12 0.33 5.79 0.33 2.02e-8 Common traits (Other); CESC cis rs921968 0.541 rs17462853 chr2:219345637 T/G cg02176678 chr2:219576539 TTLL4 -0.55 -9.93 -0.52 5.91e-20 Mean corpuscular hemoglobin concentration; CESC cis rs8016982 0.698 rs8011097 chr14:81702736 T/C cg01989461 chr14:81687754 GTF2A1 0.69 10.32 0.54 3.32e-21 Schizophrenia; CESC cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg11890956 chr21:40555474 PSMG1 -0.63 -8.65 -0.47 5.06e-16 Menarche (age at onset); CESC cis rs10504229 0.679 rs16921606 chr8:58034477 A/C cg22535103 chr8:58192502 C8orf71 -0.56 -6.48 -0.37 4.55e-10 Developmental language disorder (linguistic errors); CESC cis rs2637266 0.716 rs2579734 chr10:78441306 A/G cg18941641 chr10:78392320 NA 0.42 7.78 0.43 1.61e-13 Pulmonary function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25275331 chr1:40723935 ZMPSTE24 -0.45 -6.13 -0.35 3.26e-9 Fibrinogen levels; CESC cis rs17095355 1.000 rs11194923 chr10:111695762 A/G cg00817464 chr10:111662876 XPNPEP1 -0.45 -5.25 -0.31 3.18e-7 Biliary atresia; CESC cis rs2806561 0.754 rs10917344 chr1:23342193 C/G cg12483005 chr1:23474871 LUZP1 -0.34 -5.47 -0.32 1.03e-7 Height; CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg12963246 chr6:28129442 ZNF389 0.6 8.28 0.45 5.95e-15 Depression; CESC cis rs258892 0.843 rs16901116 chr5:72053382 A/G cg21869765 chr5:72125136 TNPO1 -0.43 -5.36 -0.31 1.8e-7 Small cell lung carcinoma; CESC cis rs4148883 0.675 rs10000357 chr4:100099942 G/C cg12011299 chr4:100065546 ADH4 0.66 9.72 0.51 2.67e-19 Alcohol dependence; CESC cis rs861020 0.606 rs4844903 chr1:210006267 C/T cg05527609 chr1:210001259 C1orf107 0.74 9.67 0.51 3.97e-19 Orofacial clefts; CESC cis rs11971779 0.941 rs6954453 chr7:139031794 C/T cg07862535 chr7:139043722 LUC7L2 0.53 5.55 0.32 6.92e-8 Diisocyanate-induced asthma; CESC cis rs11792861 0.816 rs28361186 chr9:111704064 G/A cg05043794 chr9:111880884 C9orf5 -0.39 -6.4 -0.37 7.07e-10 Menarche (age at onset); CESC cis rs5769765 0.819 rs9616377 chr22:50310880 T/C cg02269571 chr22:50332266 NA -0.57 -6.94 -0.39 3.01e-11 Schizophrenia; CESC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg06873352 chr17:61820015 STRADA 0.72 12.79 0.62 1.75e-29 Prudent dietary pattern; CESC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg01238044 chr22:24384105 GSTT1 -0.51 -6.48 -0.37 4.34e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg21017887 chr14:105400489 NA 0.41 6.65 0.38 1.65e-10 Rheumatoid arthritis; CESC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg05564831 chr3:52568323 NT5DC2 0.44 6.64 0.38 1.77e-10 Bipolar disorder; CESC cis rs2243480 1.000 rs35058610 chr7:65390925 G/A cg18252515 chr7:66147081 NA -1.06 -9.79 -0.52 1.67e-19 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15202251 chr7:100183972 FBXO24;LRCH4 -0.56 -6.44 -0.37 5.66e-10 Gut microbiome composition (summer); CESC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 9.72 0.51 2.77e-19 Platelet count; CESC cis rs7264396 0.561 rs66483315 chr20:34573575 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -8.9 -0.48 9.01e-17 Total cholesterol levels; CESC cis rs72945132 0.882 rs60780459 chr11:70162468 A/G cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg12143784 chr7:64541923 NA -0.41 -5.56 -0.32 6.67e-8 Calcium levels; CESC trans rs11098499 0.535 rs7671759 chr4:120248094 A/C cg25214090 chr10:38739885 LOC399744 0.62 8.54 0.46 1.03e-15 Corneal astigmatism; CESC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg12463550 chr7:65579703 CRCP 0.59 7.45 0.42 1.29e-12 Aortic root size; CESC cis rs9837602 1.000 rs4075038 chr3:99680086 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.54 -7.42 -0.41 1.63e-12 Breast cancer; CESC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg09781414 chr16:715207 WDR90 -0.34 -5.22 -0.31 3.58e-7 Height; CESC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.3 0.36 1.21e-9 Menopause (age at onset); CESC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg11764359 chr7:65958608 NA 0.45 5.63 0.33 4.51e-8 Calcium levels; CESC cis rs6674176 0.935 rs4314918 chr1:44377503 G/A cg13606994 chr1:44402422 ARTN -0.41 -6.01 -0.35 6.08e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6456156 0.792 rs4710183 chr6:167514083 A/G cg07741184 chr6:167504864 NA -0.38 -6.85 -0.39 5.01e-11 Primary biliary cholangitis; CESC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg05617483 chr15:76483344 C15orf27 0.42 5.62 0.33 4.95e-8 Blood metabolite levels; CESC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg18876405 chr7:65276391 NA -0.5 -5.91 -0.34 1.05e-8 Aortic root size; CESC cis rs1023500 0.573 rs13057094 chr22:42470317 T/C cg15557168 chr22:42548783 NA -0.39 -5.32 -0.31 2.19e-7 Schizophrenia; CESC trans rs10435719 0.902 rs12681142 chr8:11802601 T/C cg15556689 chr8:8085844 FLJ10661 0.52 6.63 0.38 1.91e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg18032046 chr6:28092343 ZSCAN16 -0.77 -5.3 -0.31 2.45e-7 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs3780486 0.846 rs3780487 chr9:33139237 T/C cg13443165 chr9:33130375 B4GALT1 0.44 6.37 0.36 8.54e-10 IgG glycosylation; CESC cis rs7264396 0.690 rs2425175 chr20:34445563 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.57 -0.58 2.56e-25 Total cholesterol levels; CESC cis rs7914558 1.000 rs10509757 chr10:104752960 C/T cg08650961 chr10:104748594 CNNM2 0.32 5.33 0.31 2.11e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7312933 0.576 rs11181364 chr12:42567800 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.15 0.35 2.89e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg26314531 chr2:26401878 FAM59B -0.85 -9.04 -0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs1878931 0.597 rs2680221 chr16:3462595 A/G cg02880119 chr16:3481970 NA 0.44 5.43 0.32 1.28e-7 Body mass index (adult); CESC cis rs6582630 0.555 rs7969922 chr12:38529491 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.81 0.55 8.51e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs1847202 0.859 rs13090900 chr3:72946560 C/A cg25664220 chr3:72788482 NA -0.39 -5.71 -0.33 2.97e-8 Motion sickness; CESC cis rs7178572 0.568 rs1565757 chr15:77657682 C/T cg22256960 chr15:77711686 NA -0.5 -6.45 -0.37 5.33e-10 Type 2 diabetes; CESC cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg24549020 chr5:56110836 MAP3K1 -0.52 -6.46 -0.37 4.87e-10 Initial pursuit acceleration; CESC cis rs55788414 0.932 rs9929066 chr16:81182157 G/A cg06400318 chr16:81190750 PKD1L2 -0.59 -7.04 -0.4 1.62e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs11098499 0.908 rs28559989 chr4:120386627 C/T cg09307838 chr4:120376055 NA 0.95 13.96 0.65 1.42e-33 Corneal astigmatism; CESC cis rs61931739 0.534 rs7133262 chr12:34279444 G/A cg19457237 chr12:34500585 NA -0.37 -5.19 -0.3 4.1e-7 Morning vs. evening chronotype; CESC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg16405210 chr4:1374714 KIAA1530 -0.64 -8.68 -0.47 4.09e-16 Longevity; CESC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg00409905 chr10:38381863 ZNF37A -0.45 -6.0 -0.35 6.61e-9 Extrinsic epigenetic age acceleration; CESC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg16325326 chr1:53192061 ZYG11B 0.94 16.55 0.71 9.47e-43 Monocyte count; CESC cis rs4319547 0.656 rs10161534 chr12:122873864 T/C cg05707623 chr12:122985044 ZCCHC8 -0.52 -6.21 -0.36 2.05e-9 Body mass index; CESC cis rs2592394 0.591 rs711820 chr2:176987112 T/G cg13092806 chr2:177043255 NA 0.5 5.64 0.33 4.34e-8 Magnesium levels;Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2120019 1.000 rs7167285 chr15:75368769 A/G cg09165964 chr15:75287851 SCAMP5 -0.66 -7.99 -0.44 4.25e-14 Blood trace element (Zn levels); CESC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.3 0.31 2.46e-7 Menopause (age at onset); CESC cis rs6693567 0.565 rs35784258 chr1:150405882 T/C cg09579323 chr1:150459698 TARS2 0.48 6.08 0.35 4.16e-9 Migraine; CESC cis rs2243480 1.000 rs56985706 chr7:65394562 C/T cg18252515 chr7:66147081 NA -1.0 -9.22 -0.49 9.27e-18 Diabetic kidney disease; CESC cis rs11608355 0.545 rs55902232 chr12:109902305 G/A cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs1559088 0.847 rs8100392 chr19:33605933 T/C cg27124370 chr19:33622961 WDR88 0.42 5.49 0.32 9.52e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1594829 0.553 rs7003030 chr8:26172699 G/T cg11498726 chr8:26250323 BNIP3L -0.4 -6.11 -0.35 3.54e-9 Height; CESC cis rs4481233 0.528 rs115776655 chr4:10381329 C/T cg11266682 chr4:10021025 SLC2A9 -0.44 -5.75 -0.33 2.45e-8 Metabolic traits; CESC cis rs17641971 0.662 rs10435575 chr8:49996107 C/T cg00325661 chr8:49890786 NA 0.39 5.48 0.32 9.71e-8 Blood metabolite levels; CESC cis rs11098499 0.908 rs11098527 chr4:120399906 A/G cg24375607 chr4:120327624 NA 0.45 5.44 0.32 1.19e-7 Corneal astigmatism; CESC cis rs2502731 0.539 rs3003610 chr9:130985525 G/A cg13642260 chr9:130955380 CIZ1 0.45 6.71 0.38 1.18e-10 Attention deficit hyperactivity disorder; CESC cis rs1538970 0.962 rs2153607 chr1:45813820 G/A cg05343316 chr1:45956843 TESK2 0.77 10.78 0.55 1.05e-22 Platelet count; CESC cis rs78707713 0.841 rs79069746 chr10:71205473 T/C cg12610070 chr10:71211762 TSPAN15 -0.43 -7.27 -0.41 4.12e-12 Venous thromboembolism; CESC cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.7 11.02 0.56 1.68e-23 Personality dimensions; CESC cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg17427002 chr7:12443146 VWDE -0.53 -5.18 -0.3 4.34e-7 Coronary artery disease; CESC cis rs7851660 0.844 rs10984103 chr9:100639275 G/T cg13688889 chr9:100608707 NA 0.62 8.65 0.47 5.19e-16 Strep throat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13751213 chr7:148581913 EZH2 0.6 7.02 0.4 1.83e-11 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.58 0.37 2.51e-10 Bipolar disorder; CESC cis rs832540 0.593 rs252912 chr5:56195792 C/T cg24531977 chr5:56204891 C5orf35 -0.5 -6.18 -0.35 2.46e-9 Coronary artery disease; CESC cis rs4243830 0.737 rs925745 chr1:6615690 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.8 -8.28 -0.45 5.96e-15 Body mass index; CESC cis rs6541297 0.645 rs4846920 chr1:230301574 A/G cg20703242 chr1:230279135 GALNT2 0.47 5.88 0.34 1.2e-8 Coronary artery disease; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg14925012 chr15:60771315 NARG2 -0.46 -6.53 -0.37 3.33e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg21487830 chr17:48943706 NA 0.48 6.28 0.36 1.41e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10173275 chr17:77783551 NA 0.6 6.53 0.37 3.33e-10 Gut microbiome composition (summer); CESC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg03647317 chr4:187891568 NA -0.38 -5.33 -0.31 2.09e-7 Lobe attachment (rater-scored or self-reported); CESC trans rs9951602 0.512 rs7232551 chr18:76650702 G/A cg02800362 chr5:177631904 HNRNPAB 0.66 8.66 0.47 4.55e-16 Obesity-related traits; CESC cis rs2797160 1.000 rs983543 chr6:126005767 G/A cg05901451 chr6:126070800 HEY2 -0.45 -6.53 -0.37 3.43e-10 Endometrial cancer; CESC cis rs2279817 1.000 rs905389 chr1:18021406 T/C cg21791023 chr1:18019539 ARHGEF10L 0.57 8.3 0.45 5.45e-15 Neuroticism; CESC cis rs4720575 1.000 rs4507670 chr7:47097526 C/T cg00036614 chr7:47093842 NA -0.42 -6.52 -0.37 3.53e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs4144743 1.000 rs4144744 chr17:45323262 A/G cg18085866 chr17:45331354 ITGB3 -0.66 -7.64 -0.43 3.87e-13 Body mass index; CESC cis rs447 1.000 rs12707619 chr7:83748427 T/C cg22846510 chr7:83753280 SEMA3A -0.48 -5.87 -0.34 1.27e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7208859 0.673 rs73271887 chr17:29154935 T/C cg13385521 chr17:29058706 SUZ12P 0.75 6.0 0.35 6.29e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2228479 0.850 rs62056066 chr16:89906563 G/A cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs7762018 0.891 rs3749882 chr6:170151766 C/T cg13891659 chr6:170190454 C6orf122;C6orf208 0.67 6.53 0.37 3.28e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.58 -0.32 5.8e-8 Total body bone mineral density; CESC trans rs1728785 1.000 rs864742 chr16:68575309 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs13392177 0.672 rs1877715 chr2:219052546 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.6 7.75 0.43 1.98e-13 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg26879891 chr1:152191343 HRNR -0.39 -6.11 -0.35 3.63e-9 Inflammatory skin disease; CESC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.31 0.54 3.54e-21 Platelet count; CESC trans rs11098499 0.863 rs3822190 chr4:120428098 G/A cg25214090 chr10:38739885 LOC399744 0.71 9.7 0.51 3.06e-19 Corneal astigmatism; CESC cis rs798554 0.679 rs798499 chr7:2792013 G/A cg09658497 chr7:2847517 GNA12 -0.35 -5.39 -0.31 1.59e-7 Height; CESC cis rs7762018 0.607 rs79355059 chr6:170062157 T/C cg15199489 chr6:170068458 WDR27 0.67 5.2 0.3 3.98e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg27165867 chr14:105738592 BRF1 -0.54 -5.82 -0.34 1.72e-8 Mean platelet volume;Platelet distribution width; CESC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg21573476 chr21:45109991 RRP1B -0.53 -7.96 -0.44 5.15e-14 Mean corpuscular volume; CESC cis rs34375054 0.573 rs12579211 chr12:125647752 C/T cg25124228 chr12:125621409 AACS -0.52 -5.64 -0.33 4.33e-8 Post bronchodilator FEV1/FVC ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21662326 chr11:14521493 COPB1 0.6 6.73 0.38 1.02e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg00166722 chr3:10149974 C3orf24 0.5 6.35 0.36 9.36e-10 Alzheimer's disease; CESC trans rs634534 0.532 rs12794370 chr11:65770413 G/A cg17712092 chr4:129076599 LARP1B 0.69 9.68 0.51 3.54e-19 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs2730245 0.527 rs712199 chr7:158662250 A/G cg24397884 chr7:158709396 WDR60 0.82 8.32 0.46 4.73e-15 Height; CESC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Depression; CESC trans rs61931739 0.534 rs11052984 chr12:34045904 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.22 0.41 5.44e-12 Morning vs. evening chronotype; CESC trans rs7395662 0.534 rs12418219 chr11:48988091 G/T cg00717180 chr2:96193071 NA -0.45 -6.07 -0.35 4.52e-9 HDL cholesterol; CESC cis rs7824557 0.534 rs10092549 chr8:11089079 C/G cg21775007 chr8:11205619 TDH -0.34 -5.08 -0.3 7.12e-7 Retinal vascular caliber; CESC cis rs4253772 0.637 rs6008357 chr22:46652104 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.18 0.45 1.16e-14 LDL cholesterol;Cholesterol, total; CESC cis rs17253792 0.822 rs80321745 chr14:56162947 T/A cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs9910055 0.529 rs615070 chr17:42176591 A/G cg19774624 chr17:42201019 HDAC5 -0.56 -7.46 -0.42 1.21e-12 Total body bone mineral density; CESC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg00166722 chr3:10149974 C3orf24 0.54 6.61 0.38 2.15e-10 Alzheimer's disease; CESC cis rs10129255 0.536 rs8004835 chr14:107142378 A/C cg07958169 chr14:107095056 NA -0.46 -6.92 -0.39 3.33e-11 Kawasaki disease; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg07484894 chr20:34330300 RBM39 0.42 6.13 0.35 3.16e-9 Positive affect; CESC cis rs9611565 0.608 rs202652 chr22:41838792 A/G cg03806693 chr22:41940476 POLR3H 1.13 15.27 0.68 3.52e-38 Vitiligo; CESC cis rs16895831 0.519 rs16895863 chr6:42571346 A/T cg10605015 chr6:42532144 UBR2 -0.52 -5.75 -0.33 2.44e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg14703610 chr5:56206110 C5orf35 0.49 6.6 0.38 2.17e-10 Breast cancer;Breast cancer (early onset); CESC cis rs9513627 0.573 rs7325697 chr13:100117793 A/G cg25919922 chr13:100150906 NA 0.61 5.99 0.35 6.63e-9 Obesity-related traits; CESC cis rs6570726 0.967 rs373704 chr6:145860618 C/A cg23711669 chr6:146136114 FBXO30 0.76 11.07 0.56 1.15e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg01988459 chr11:68622903 NA -0.4 -5.23 -0.31 3.38e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9911578 0.935 rs6503878 chr17:56884581 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.24 0.31 3.23e-7 Intelligence (multi-trait analysis); CESC cis rs10979 0.928 rs6924967 chr6:143906235 C/T cg25407410 chr6:143891975 LOC285740 -0.62 -9.16 -0.49 1.42e-17 Hypospadias; CESC cis rs654950 0.875 rs633297 chr1:41985453 A/C cg06885757 chr1:42089581 HIVEP3 0.43 6.87 0.39 4.6e-11 Airway imaging phenotypes; CESC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg18876405 chr7:65276391 NA -0.52 -7.03 -0.4 1.71e-11 Aortic root size; CESC cis rs1018836 0.923 rs10956749 chr8:91621573 G/A cg16814680 chr8:91681699 NA -0.72 -10.07 -0.53 2.11e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21300382 chr19:13248092 NACC1 0.47 6.61 0.38 2.06e-10 Fibrinogen levels; CESC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.77 10.24 0.53 5.91e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6942756 0.956 rs13235668 chr7:128879710 A/G cg02491457 chr7:128862824 NA -0.7 -10.17 -0.53 9.75e-21 White matter hyperintensity burden; CESC cis rs2228479 0.702 rs2074903 chr16:89811663 T/C cg00800038 chr16:89945340 TCF25 -0.9 -7.51 -0.42 9.11e-13 Skin colour saturation; CESC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.47 -0.37 4.81e-10 Life satisfaction; CESC cis rs12477438 0.520 rs11123765 chr2:99768064 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 16.02 0.7 7.14e-41 Chronic sinus infection; CESC cis rs4746818 0.901 rs4746816 chr10:70874866 G/T cg11621586 chr10:70884670 VPS26A 0.87 8.48 0.46 1.56e-15 Left atrial antero-posterior diameter; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09349940 chr16:22218118 EEF2K -0.65 -7.44 -0.42 1.38e-12 Gut microbiome composition (summer); CESC cis rs6831352 0.918 rs17817359 chr4:100054197 G/T cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs6570726 0.791 rs6914203 chr6:145899975 C/A cg23711669 chr6:146136114 FBXO30 0.9 13.68 0.64 1.38e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs7843479 1.000 rs2054711 chr8:21818060 A/G cg17168535 chr8:21777572 XPO7 0.49 6.73 0.38 1.02e-10 Mean corpuscular volume; CESC trans rs11098499 0.754 rs1980027 chr4:120251577 C/T cg25214090 chr10:38739885 LOC399744 0.62 8.81 0.48 1.69e-16 Corneal astigmatism; CESC cis rs7582720 0.943 rs72926800 chr2:203829225 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7520050 0.778 rs2934857 chr1:46039612 A/G cg03146154 chr1:46216737 IPP 0.5 6.53 0.37 3.31e-10 Red blood cell count;Reticulocyte count; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg17237603 chr7:148876528 ZNF398 0.46 6.5 0.37 3.86e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs933688 1.000 rs2059207 chr5:90731931 C/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.1 15.13 0.68 1.06e-37 Smoking behavior; CESC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg07701084 chr6:150067640 NUP43 0.42 5.87 0.34 1.3e-8 Lung cancer; CESC cis rs4835473 0.932 rs4835126 chr4:144918893 A/G cg25736465 chr4:144833511 NA 0.42 6.28 0.36 1.38e-9 Immature fraction of reticulocytes; CESC cis rs826838 0.806 rs826873 chr12:39121305 G/A cg13010199 chr12:38710504 ALG10B -0.46 -6.44 -0.37 5.5e-10 Heart rate; CESC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg07395648 chr5:131743802 NA -0.43 -5.67 -0.33 3.73e-8 Blood metabolite levels; CESC cis rs881375 0.715 rs11794516 chr9:123640230 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.44 6.21 0.36 2.03e-9 Rheumatoid arthritis; CESC cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg05340658 chr4:99064831 C4orf37 0.82 12.91 0.62 6.51e-30 Colonoscopy-negative controls vs population controls; CESC cis rs56104184 0.775 rs17272707 chr19:49404535 T/G cg21252483 chr19:49399788 TULP2 -0.49 -5.56 -0.32 6.67e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs9399135 0.967 rs11754783 chr6:135347661 T/A cg24558204 chr6:135376177 HBS1L 0.52 7.29 0.41 3.48e-12 Red blood cell count; CESC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg22875332 chr1:76189707 ACADM 0.69 9.24 0.49 8.13e-18 Blood metabolite levels;Acylcarnitine levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03969138 chr6:7390163 RIOK1;CAGE1 0.45 6.01 0.35 5.96e-9 Systemic lupus erythematosus; CESC cis rs6867032 0.527 rs1017924 chr5:1976187 C/T cg26168224 chr5:2018326 NA 0.78 11.69 0.58 9.73e-26 Gut microbiome composition (winter); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg02905599 chr12:133249096 POLE -0.44 -6.28 -0.36 1.41e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs929354 0.772 rs1002389 chr7:156968323 C/G cg05182265 chr7:156933206 UBE3C -0.5 -7.3 -0.41 3.28e-12 Body mass index; CESC cis rs7762018 0.943 rs11546265 chr6:170108363 G/A cg05834625 chr6:170176447 C6orf70 0.64 7.81 0.43 1.37e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27600497 chr7:155091023 INSIG1 -0.57 -6.51 -0.37 3.85e-10 Gut microbiome composition (summer); CESC cis rs2115630 0.846 rs8024538 chr15:85368419 A/T cg12501888 chr15:85177176 SCAND2 -0.43 -5.49 -0.32 9.45e-8 P wave terminal force; CESC cis rs8070128 0.534 rs2955350 chr17:17953548 G/A cg16928487 chr17:17741425 SREBF1 0.55 9.13 0.49 1.86e-17 Total body bone mineral density; CESC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg22535103 chr8:58192502 C8orf71 -0.92 -10.16 -0.53 1.04e-20 Developmental language disorder (linguistic errors); CESC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg03806693 chr22:41940476 POLR3H 1.19 14.07 0.65 6.09e-34 Vitiligo; CESC cis rs4919044 0.756 rs2486686 chr10:94778511 G/T cg16508068 chr10:94451736 HHEX -0.5 -5.49 -0.32 9.61e-8 Coronary artery disease; CESC cis rs9291683 0.632 rs12508991 chr4:10041104 C/T cg00071950 chr4:10020882 SLC2A9 0.83 14.41 0.66 3.63e-35 Bone mineral density; CESC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -5.72 -0.33 2.85e-8 Extrinsic epigenetic age acceleration; CESC cis rs7216064 1.000 rs9897982 chr17:65879592 G/T cg12091567 chr17:66097778 LOC651250 -0.83 -9.57 -0.51 8.04e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9815354 1.000 rs9815354 chr3:41912651 G/A cg03022575 chr3:42003672 ULK4 0.58 5.91 0.34 1.05e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg19318889 chr4:1322082 MAEA 0.46 6.32 0.36 1.08e-9 Longevity; CESC cis rs8020095 0.571 rs7157126 chr14:67488230 C/G cg19548862 chr14:67692701 FAM71D -0.49 -6.03 -0.35 5.44e-9 Depression (quantitative trait); CESC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg17372223 chr3:52568218 NT5DC2 0.44 6.63 0.38 1.86e-10 Bipolar disorder; CESC cis rs703842 1.000 rs10877014 chr12:58167661 A/G cg00677455 chr12:58241039 CTDSP2 0.53 6.99 0.39 2.23e-11 Multiple sclerosis; CESC cis rs1153858 1.000 rs2461702 chr15:45647427 A/G cg21132104 chr15:45694354 SPATA5L1 0.76 10.17 0.53 1.03e-20 Homoarginine levels; CESC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg03806693 chr22:41940476 POLR3H -1.12 -13.57 -0.64 3.28e-32 Crohn's disease;Inflammatory bowel disease; CESC cis rs250677 0.652 rs250675 chr5:148438565 A/C cg18129178 chr5:148520854 ABLIM3 0.53 5.77 0.33 2.17e-8 Breast cancer; CESC trans rs9929218 0.551 rs2296408 chr16:68713823 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.97 -17.29 -0.73 2.32e-45 Colorectal cancer; CESC cis rs6120849 0.901 rs6058194 chr20:33739831 G/A cg24642439 chr20:33292090 TP53INP2 0.62 6.58 0.37 2.54e-10 Protein C levels; CESC cis rs7264396 0.635 rs6058382 chr20:34553948 C/T cg17201900 chr20:34330562 RBM39 0.51 5.31 0.31 2.37e-7 Total cholesterol levels; CESC cis rs9910055 0.530 rs2269908 chr17:42294198 G/C cg08499158 chr17:42289980 UBTF -0.41 -5.26 -0.31 3e-7 Total body bone mineral density; CESC cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg18512352 chr11:47633146 NA -0.52 -7.48 -0.42 1.11e-12 Subjective well-being; CESC cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs13242816 1.000 rs4292624 chr7:116102724 A/C cg04696780 chr7:116139425 CAV2 -0.62 -5.69 -0.33 3.31e-8 P wave duration; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18502522 chr15:75165624 SCAMP2 -0.47 -6.11 -0.35 3.62e-9 Ulcerative colitis; CESC cis rs6815814 0.950 rs66922907 chr4:38812537 A/G cg02016764 chr4:38805732 TLR1 -0.62 -7.43 -0.42 1.5e-12 Breast cancer; CESC cis rs1465370 0.682 rs741486 chr7:130024010 C/T cg04743876 chr7:130013617 NA -0.29 -5.5 -0.32 8.89e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs9513593 1.000 rs2182954 chr13:99937082 A/G cg21788972 chr13:99853209 UBAC2 0.54 6.47 0.37 4.77e-10 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16280098 chr14:23790882 PABPN1 0.58 6.64 0.38 1.81e-10 Gut microbiome composition (summer); CESC cis rs6690583 0.623 rs893618 chr1:85513770 C/T cg11262906 chr1:85462892 MCOLN2 0.52 5.21 0.3 3.82e-7 Serum sulfate level; CESC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg17650747 chr5:1873721 NA 0.41 5.69 0.33 3.31e-8 Cardiovascular disease risk factors; CESC cis rs4561483 0.734 rs33655 chr16:11970381 C/T cg08843971 chr16:11963173 GSPT1 -0.56 -8.39 -0.46 2.93e-15 Testicular germ cell tumor; CESC cis rs9902453 0.808 rs4595850 chr17:28206326 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.12 0.45 1.77e-14 Coffee consumption (cups per day); CESC cis rs28489187 0.638 rs233055 chr1:85798486 A/C cg16011679 chr1:85725395 C1orf52 0.46 5.52 0.32 7.91e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.66 10.03 0.52 2.84e-20 Personality dimensions; CESC cis rs2295499 0.673 rs4690016 chr4:2707132 G/A cg27239842 chr4:2403781 ZFYVE28 -0.34 -5.66 -0.33 3.98e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs8077577 0.747 rs1925 chr17:18177715 G/A cg16794390 chr17:18148240 FLII 0.42 6.59 0.38 2.32e-10 Obesity-related traits; CESC cis rs523522 0.962 rs10849754 chr12:120940418 A/C cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC trans rs9929218 0.954 rs2059254 chr16:68817439 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.38 -0.46 3.2e-15 Colorectal cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14339556 chr9:36572881 MELK -0.44 -7.29 -0.41 3.56e-12 Gambling; CESC cis rs12477438 0.834 rs1563107 chr2:99701276 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.67 9.13 0.49 1.8e-17 Chronic sinus infection; CESC cis rs644799 0.710 rs10831429 chr11:95508524 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.75 0.59 6.37e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6987853 0.712 rs2974343 chr8:42400679 G/A cg09913449 chr8:42400586 C8orf40 0.45 7.63 0.42 4.28e-13 Mean corpuscular hemoglobin concentration; CESC trans rs8135828 0.770 rs5763300 chr22:29927704 T/C cg17961835 chr3:126195582 ZXDC -0.45 -6.11 -0.35 3.53e-9 Lipid traits; CESC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg12311346 chr5:56204834 C5orf35 -0.75 -8.79 -0.48 1.93e-16 Initial pursuit acceleration; CESC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg04518342 chr5:131593106 PDLIM4 -0.36 -5.14 -0.3 5.39e-7 Breast cancer; CESC cis rs6089829 0.692 rs6122349 chr20:61664096 T/C cg08564027 chr20:61660810 NA 0.79 9.99 0.52 3.8e-20 Prostate cancer (SNP x SNP interaction); CESC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.37 5.32 0.31 2.24e-7 Electroencephalogram traits; CESC cis rs2228479 0.850 rs17226666 chr16:89835401 G/A cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg10560079 chr2:191398806 TMEM194B -0.49 -7.05 -0.4 1.51e-11 Pulse pressure; CESC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg11644478 chr21:40555479 PSMG1 1.03 16.6 0.71 6.66e-43 Cognitive function; CESC cis rs941408 1.000 rs1640271 chr19:2799979 C/T cg06609049 chr19:2785107 THOP1 0.7 10.51 0.54 7.95e-22 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10651637 chr15:45315642 SORD 0.52 6.38 0.36 7.77e-10 Gut microbiome composition (summer); CESC cis rs2066819 1.000 rs2695788 chr12:56697110 G/A cg26714650 chr12:56694279 CS 1.29 16.3 0.71 7.7e-42 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06212607 chr1:235491708 GGPS1;ARID4B -0.56 -6.56 -0.37 2.74e-10 Gut microbiome composition (summer); CESC cis rs977987 0.806 rs4887824 chr16:75441613 T/C cg03315344 chr16:75512273 CHST6 0.41 5.86 0.34 1.35e-8 Dupuytren's disease; CESC cis rs1215050 0.791 rs165239 chr4:98682549 C/T cg05340658 chr4:99064831 C4orf37 0.47 6.04 0.35 5.08e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs12474201 0.572 rs7596521 chr2:46918665 A/G cg06386533 chr2:46925753 SOCS5 0.52 6.3 0.36 1.27e-9 Height; CESC cis rs4604732 0.631 rs75600450 chr1:247625492 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.43 5.35 0.31 1.88e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7267979 1.000 rs6050544 chr20:25320228 T/A cg08601574 chr20:25228251 PYGB -0.38 -5.42 -0.32 1.33e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs3736485 0.934 rs8036821 chr15:51861646 A/G cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3126085 0.877 rs868304 chr1:152178568 G/A cg03465714 chr1:152285911 FLG -0.43 -5.16 -0.3 4.81e-7 Atopic dermatitis; CESC cis rs10465746 0.780 rs7529293 chr1:84331981 A/G cg10977910 chr1:84465055 TTLL7 0.5 6.99 0.39 2.19e-11 Obesity-related traits; CESC cis rs3008870 0.677 rs2815354 chr1:67483642 A/T cg08660285 chr1:67390436 MIER1;WDR78 1.0 11.1 0.56 8.91e-24 Lymphocyte percentage of white cells; CESC cis rs965469 0.724 rs6037527 chr20:3254412 T/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.36 -0.31 1.8e-7 IFN-related cytopenia; CESC cis rs8049040 0.547 rs12929335 chr16:71435752 G/A cg08717414 chr16:71523259 ZNF19 -0.6 -6.65 -0.38 1.63e-10 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17173397 chr1:20539594 NA 0.59 6.59 0.38 2.34e-10 Gut microbiome composition (summer); CESC cis rs2760061 0.598 rs632832 chr1:228121838 G/T cg01973587 chr1:228161476 NA 0.37 5.66 0.33 4e-8 Diastolic blood pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27304813 chr3:120068385 LRRC58 -0.48 -6.92 -0.39 3.4e-11 Gambling; CESC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg11890956 chr21:40555474 PSMG1 1.17 21.69 0.8 1.08e-60 Cognitive function; CESC cis rs5769707 0.967 rs4524218 chr22:50018639 G/A cg20744362 chr22:50050164 C22orf34 0.46 8.08 0.44 2.23e-14 Monocyte count;Monocyte percentage of white cells; CESC cis rs6921919 0.583 rs9468355 chr6:28341877 A/G cg04861640 chr6:28234605 ZNF187 -0.36 -5.04 -0.3 8.71e-7 Autism spectrum disorder or schizophrenia; CESC cis rs11645898 0.935 rs8047881 chr16:72193906 A/G cg14768367 chr16:72042858 DHODH -0.56 -5.05 -0.3 8.18e-7 Blood protein levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02034563 chr2:179060011 OSBPL6 0.47 6.65 0.38 1.65e-10 Systemic lupus erythematosus; CESC cis rs4642101 0.793 rs12714880 chr3:12832101 G/A cg05775895 chr3:12838266 CAND2 0.35 5.32 0.31 2.25e-7 QRS complex (12-leadsum); CESC cis rs12681366 0.734 rs2931633 chr8:95422720 G/A cg13257157 chr8:95487014 RAD54B 0.38 5.13 0.3 5.47e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs12541635 0.966 rs55762012 chr8:107033218 T/C cg10147462 chr8:107024639 NA 0.42 5.9 0.34 1.12e-8 Age of smoking initiation; CESC cis rs80130819 0.591 rs10875783 chr12:48649736 G/A cg05342945 chr12:48394962 COL2A1 -0.49 -5.33 -0.31 2.14e-7 Prostate cancer; CESC cis rs7927592 0.956 rs7104877 chr11:68377602 G/T cg16797656 chr11:68205561 LRP5 -0.38 -5.47 -0.32 1.04e-7 Total body bone mineral density; CESC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg18904891 chr8:8559673 CLDN23 0.68 7.56 0.42 6.58e-13 Obesity-related traits; CESC cis rs4654899 0.865 rs960564 chr1:21416435 G/T cg05370193 chr1:21551575 ECE1 0.44 6.76 0.38 8.66e-11 Superior frontal gyrus grey matter volume; CESC trans rs875971 0.965 rs9969301 chr7:65781655 G/A cg26939375 chr7:64535504 NA -0.45 -6.04 -0.35 5.31e-9 Aortic root size; CESC cis rs2066819 1.000 rs79718165 chr12:56644251 C/T cg26714650 chr12:56694279 CS -1.42 -10.05 -0.53 2.39e-20 Psoriasis vulgaris; CESC cis rs4474465 1.000 rs12277701 chr11:78140726 A/T cg27205649 chr11:78285834 NARS2 -0.42 -5.1 -0.3 6.41e-7 Alzheimer's disease (survival time); CESC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg11843238 chr5:131593191 PDLIM4 0.35 5.21 0.3 3.8e-7 Breast cancer; CESC cis rs4481887 0.893 rs4576683 chr1:248472390 T/C cg00666640 chr1:248458726 OR2T12 0.34 5.89 0.34 1.18e-8 Common traits (Other); CESC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg08859206 chr1:53392774 SCP2 -0.57 -7.47 -0.42 1.17e-12 Monocyte count; CESC cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg22862634 chr11:62369728 EML3;MTA2 0.61 8.6 0.47 6.91e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9814567 1.000 rs9864439 chr3:134298671 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.44 -0.32 1.23e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7247513 0.701 rs8107642 chr19:12766370 C/T cg23899408 chr19:12877188 HOOK2 0.45 5.41 0.32 1.44e-7 Bipolar disorder; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17896229 chr20:5294595 PROKR2 -0.43 -6.68 -0.38 1.38e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg03433033 chr1:76189801 ACADM 0.62 6.27 0.36 1.49e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1707322 0.686 rs11211179 chr1:46228082 A/C cg06784218 chr1:46089804 CCDC17 0.4 7.33 0.41 2.85e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg22800045 chr5:56110881 MAP3K1 -0.61 -7.68 -0.43 3.13e-13 Initial pursuit acceleration; CESC cis rs9435341 0.896 rs1623927 chr1:107596120 T/C cg09367891 chr1:107599246 PRMT6 -0.71 -8.35 -0.46 3.85e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs854765 0.583 rs62064158 chr17:17826935 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.28 0.41 3.9e-12 Total body bone mineral density; CESC cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9329289 0.603 rs2458705 chr10:2541377 A/G cg15501526 chr10:2543763 NA 0.64 10.86 0.55 5.83e-23 Age-related hearing impairment; CESC cis rs3096299 0.967 rs753853 chr16:89446525 G/T cg08822215 chr16:89438651 ANKRD11 -0.42 -6.35 -0.36 9.47e-10 Multiple myeloma (IgH translocation); CESC cis rs1506636 1.000 rs2429616 chr7:123406034 C/T cg03229431 chr7:123269106 ASB15 0.5 6.73 0.38 1.03e-10 Plateletcrit;Platelet count; CESC cis rs2486288 0.656 rs8039352 chr15:45551790 A/G cg21132104 chr15:45694354 SPATA5L1 -0.59 -6.96 -0.39 2.67e-11 Glomerular filtration rate; CESC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg18876405 chr7:65276391 NA 0.51 5.96 0.34 8.21e-9 Aortic root size; CESC cis rs2953145 0.568 rs2975752 chr2:241521327 A/G cg03371404 chr2:241525653 CAPN10 -0.56 -6.02 -0.35 5.67e-9 Bipolar disorder; CESC cis rs3820068 0.580 rs12746773 chr1:16001588 C/T cg18133145 chr1:16060689 PLEKHM2 -0.43 -5.22 -0.31 3.7e-7 Systolic blood pressure; CESC cis rs7615952 1.000 rs7615952 chr3:125649403 A/C cg05084668 chr3:125655381 ALG1L 0.48 5.99 0.35 6.65e-9 Blood pressure (smoking interaction); CESC cis rs734999 0.588 rs2764848 chr1:2530694 G/A cg20673091 chr1:2541236 MMEL1 -0.44 -7.28 -0.41 3.75e-12 Ulcerative colitis; CESC cis rs9487051 0.768 rs12176068 chr6:109521629 C/T cg01475377 chr6:109611718 NA -0.46 -6.93 -0.39 3.18e-11 Reticulocyte fraction of red cells; CESC cis rs7914558 0.933 rs2066323 chr10:104871361 A/G cg04362960 chr10:104952993 NT5C2 0.46 5.92 0.34 9.98e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13665852 chr10:13146898 OPTN 0.51 7.04 0.4 1.61e-11 Fibrinogen levels; CESC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg18402987 chr7:1209562 NA 0.76 7.55 0.42 7.26e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9929218 1.000 rs4783681 chr16:68806508 C/A cg02972257 chr16:68554789 NA 0.43 5.12 0.3 5.89e-7 Colorectal cancer; CESC cis rs10744422 1.000 rs10847869 chr12:123328359 C/G cg25930673 chr12:123319894 HIP1R -0.65 -5.28 -0.31 2.72e-7 Schizophrenia; CESC cis rs2933343 0.700 rs789239 chr3:128633808 T/C cg24203234 chr3:128598194 ACAD9 0.39 5.27 0.31 2.78e-7 IgG glycosylation; CESC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg18252515 chr7:66147081 NA 0.48 6.43 0.37 5.77e-10 Aortic root size; CESC cis rs6484504 0.576 rs169623 chr11:31184157 T/C cg14844989 chr11:31128820 NA -0.43 -6.07 -0.35 4.34e-9 Red blood cell count; CESC cis rs9486715 1.000 rs3798297 chr6:97062835 C/T cg18709589 chr6:96969512 KIAA0776 -0.44 -6.2 -0.36 2.17e-9 Headache; CESC cis rs17253792 0.822 rs78143160 chr14:56150097 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs3093024 0.595 rs4458654 chr6:167476068 A/C cg07741184 chr6:167504864 NA 0.38 6.7 0.38 1.22e-10 Rheumatoid arthritis; CESC cis rs7395581 0.797 rs10838681 chr11:47275064 C/T cg25783544 chr11:47291846 MADD 0.58 6.93 0.39 3.16e-11 HDL cholesterol; CESC trans rs35110281 0.715 rs2838320 chr21:44995037 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 7.12 0.4 9.96e-12 Mean corpuscular volume; CESC cis rs7605827 0.893 rs7590540 chr2:15719652 A/T cg19274914 chr2:15703543 NA 0.33 6.02 0.35 5.69e-9 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16757658 chr11:126138769 SRPR;FOXRED1 0.61 7.42 0.41 1.59e-12 Gut microbiome composition (summer); CESC cis rs826838 0.935 rs1684407 chr12:39127270 C/T cg26384229 chr12:38710491 ALG10B -0.67 -10.95 -0.56 2.81e-23 Heart rate; CESC cis rs2204008 0.527 rs8189480 chr12:38345648 C/T cg26384229 chr12:38710491 ALG10B -0.5 -6.69 -0.38 1.3e-10 Bladder cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07404466 chr20:56064128 HMGB1L1 -0.43 -6.18 -0.35 2.38e-9 Gut microbiota (bacterial taxa); CESC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.42 0.37 6.09e-10 Bipolar disorder; CESC cis rs4076764 0.801 rs4571944 chr1:163367975 T/C cg06092702 chr1:163392909 NA -0.39 -5.6 -0.33 5.37e-8 Motion sickness; CESC cis rs7520050 0.778 rs2934857 chr1:46039612 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.9 0.34 1.12e-8 Red blood cell count;Reticulocyte count; CESC trans rs11098499 0.662 rs13108589 chr4:120268102 G/C cg25214090 chr10:38739885 LOC399744 0.62 8.49 0.46 1.46e-15 Corneal astigmatism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19319069 chr7:129593010 UBE2H 0.46 6.43 0.37 5.8e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg22520471 chr17:61851767 DDX42;CCDC47 -0.81 -11.35 -0.57 1.34e-24 Prudent dietary pattern; CESC trans rs208520 1.000 rs72884033 chr6:66995747 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.14 0.49 1.65e-17 Exhaled nitric oxide output; CESC cis rs9796 0.689 rs561301 chr15:41444723 C/T cg12426344 chr15:41135900 SPINT1 -0.25 -5.41 -0.32 1.43e-7 Menopause (age at onset); CESC cis rs9486715 0.838 rs9400034 chr6:96954566 C/T cg06623918 chr6:96969491 KIAA0776 0.93 14.38 0.66 4.75e-35 Headache; CESC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg04277193 chr17:41438351 NA 0.48 5.07 0.3 7.51e-7 Menopause (age at onset); CESC cis rs8067354 0.574 rs7219089 chr17:58032865 C/T cg02344993 chr17:57696989 CLTC 0.52 5.33 0.31 2.1e-7 Hemoglobin concentration; CESC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg22823121 chr1:150693482 HORMAD1 0.47 6.51 0.37 3.7e-10 Melanoma; CESC trans rs17135859 0.817 rs6889348 chr5:112965145 A/G cg21932672 chr1:95584445 TMEM56 0.42 6.27 0.36 1.43e-9 F-cell distribution; CESC cis rs933688 1.000 rs1035477 chr5:90743325 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 13.7 0.64 1.17e-32 Smoking behavior; CESC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg18904891 chr8:8559673 CLDN23 0.68 8.07 0.44 2.48e-14 Obesity-related traits; CESC cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg06713675 chr4:122721982 EXOSC9 -0.47 -6.56 -0.37 2.87e-10 Type 2 diabetes; CESC cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg08847533 chr14:75593920 NEK9 -0.9 -15.59 -0.69 2.49e-39 Height; CESC cis rs1348850 0.526 rs9288003 chr2:178446572 T/G cg22681709 chr2:178499509 PDE11A -0.45 -5.24 -0.31 3.27e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg22535103 chr8:58192502 C8orf71 -1.07 -13.57 -0.64 3.2e-32 Developmental language disorder (linguistic errors); CESC cis rs9660992 0.674 rs17345837 chr1:205263122 C/T cg00857998 chr1:205179979 DSTYK 0.48 5.48 0.32 9.88e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg20243544 chr17:37824526 PNMT -0.45 -5.44 -0.32 1.23e-7 Glomerular filtration rate (creatinine); CESC cis rs3008870 0.920 rs12132532 chr1:67457015 G/T cg02640540 chr1:67518911 SLC35D1 -0.52 -5.66 -0.33 3.9e-8 Lymphocyte percentage of white cells; CESC cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg26597838 chr10:835615 NA 0.79 9.46 0.5 1.69e-18 Eosinophil percentage of granulocytes; CESC cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.99 0.56 2.18e-23 Hip circumference adjusted for BMI; CESC cis rs4523957 0.786 rs59428454 chr17:2114063 T/A cg16513277 chr17:2031491 SMG6 -0.64 -8.9 -0.48 9.15e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2635047 0.967 rs2576060 chr18:44637106 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -7.26 -0.41 4.26e-12 Educational attainment; CESC cis rs1878931 0.507 rs35214904 chr16:3410017 C/A cg02880119 chr16:3481970 NA 0.42 5.38 0.31 1.65e-7 Body mass index (adult); CESC cis rs1808579 0.935 rs57440424 chr18:21108614 G/A cg14672496 chr18:21087552 C18orf8 0.41 6.29 0.36 1.33e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs9399137 0.507 rs10484496 chr6:135299682 T/C cg24558204 chr6:135376177 HBS1L 0.7 9.61 0.51 5.93e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs2180341 1.000 rs6569478 chr6:127598619 G/A cg27446573 chr6:127587934 RNF146 1.07 15.98 0.7 1e-40 Breast cancer; CESC cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg12923728 chr3:195709715 SDHAP1 -0.68 -9.13 -0.49 1.76e-17 Pancreatic cancer; CESC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg25036284 chr2:26402008 FAM59B -0.74 -8.4 -0.46 2.72e-15 Gut microbiome composition (summer); CESC cis rs1865721 1.000 rs17284077 chr18:73204128 C/T cg26385618 chr18:73139727 C18orf62 -0.52 -7.75 -0.43 1.96e-13 Intelligence; CESC cis rs11690935 0.959 rs6758704 chr2:172655097 T/C cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.76 -0.67 2.21e-36 Schizophrenia; CESC cis rs2651899 0.867 rs207200 chr1:3073555 T/C cg07622451 chr1:3079886 PRDM16 0.3 5.42 0.32 1.37e-7 Migraine; CESC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg00864171 chr11:67383662 NA 0.34 5.08 0.3 7.24e-7 Mean corpuscular volume; CESC cis rs910316 1.000 rs12589876 chr14:75544189 G/A cg11812906 chr14:75593930 NEK9 0.9 15.28 0.68 3.01e-38 Height; CESC cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg27347728 chr4:17578864 LAP3 0.44 5.07 0.3 7.43e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2243480 1.000 rs13247184 chr7:65358928 A/G cg25894440 chr7:65020034 NA -0.63 -5.42 -0.32 1.33e-7 Diabetic kidney disease; CESC cis rs6570726 0.935 rs395948 chr6:145820185 G/A cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg23754390 chr11:835074 CD151 0.33 5.96 0.34 8.2e-9 Mean platelet volume; CESC cis rs11077998 0.935 rs11653926 chr17:80484953 G/A cg10255544 chr17:80519551 FOXK2 0.55 9.01 0.48 4.32e-17 Reticulocyte fraction of red cells; CESC cis rs9287719 0.967 rs13034061 chr2:10739651 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs6460942 1.000 rs62448563 chr7:12400040 G/A cg06484146 chr7:12443880 VWDE -0.69 -7.97 -0.44 4.71e-14 Coronary artery disease; CESC cis rs4629180 0.920 rs4851458 chr2:102108794 T/C cg01388757 chr2:102091195 RFX8 -0.43 -6.61 -0.38 2.12e-10 Chronic rhinosinusitis with nasal polyps; CESC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg24531977 chr5:56204891 C5orf35 0.69 9.4 0.5 2.69e-18 Initial pursuit acceleration; CESC cis rs2439831 0.867 rs933941 chr15:43632226 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.48 0.54 1.04e-21 Lung cancer in ever smokers; CESC cis rs6964587 1.000 rs13245393 chr7:91641928 A/G cg17063962 chr7:91808500 NA 0.56 7.76 0.43 1.79e-13 Breast cancer; CESC cis rs9457247 1.000 rs10946198 chr6:167404432 C/T cg23791538 chr6:167370224 RNASET2 -0.59 -8.42 -0.46 2.44e-15 Crohn's disease; CESC cis rs901683 1.000 rs12775527 chr10:46024990 G/A cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs711830 1.000 rs711830 chr2:177037311 C/T cg13092806 chr2:177043255 NA -0.86 -11.92 -0.59 1.69e-26 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CESC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg22535103 chr8:58192502 C8orf71 0.8 8.72 0.47 3.07e-16 Developmental language disorder (linguistic errors); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11450715 chr2:171627404 NA -0.46 -6.6 -0.38 2.27e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.2 -0.3 4.08e-7 Lung cancer; CESC cis rs2485892 0.581 rs2484032 chr1:210317225 G/A cg21951975 chr1:209979733 IRF6 0.44 5.65 0.33 4.19e-8 Manic episodes in bipolar disorder; CESC cis rs9905704 0.846 rs302861 chr17:56697040 G/C cg12560992 chr17:57184187 TRIM37 0.62 7.73 0.43 2.17e-13 Testicular germ cell tumor; CESC cis rs1915146 0.546 rs2454055 chr10:126859832 T/C cg23000734 chr10:126850823 CTBP2 0.54 8.0 0.44 3.93e-14 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22798412 chr1:1156246 SDF4 -0.56 -6.57 -0.37 2.64e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg04944784 chr2:26401820 FAM59B 0.93 10.54 0.54 6.17e-22 Gut microbiome composition (summer); CESC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg18758796 chr5:131593413 PDLIM4 0.52 7.64 0.42 3.97e-13 Acylcarnitine levels; CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg18591801 chr3:52553433 STAB1 -0.3 -5.78 -0.33 2.1e-8 Electroencephalogram traits; CESC cis rs7523050 0.643 rs34114412 chr1:109402866 C/T cg08274380 chr1:109419600 GPSM2 0.86 5.69 0.33 3.36e-8 Fat distribution (HIV); CESC cis rs8070128 0.583 rs7406982 chr17:17942613 C/T cg09796270 chr17:17721594 SREBF1 0.38 5.07 0.3 7.66e-7 Total body bone mineral density; CESC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg26818010 chr10:134567672 INPP5A -0.9 -10.89 -0.56 4.7e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs854765 0.547 rs28537385 chr17:17902135 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.51 0.37 3.74e-10 Total body bone mineral density; CESC cis rs763121 0.853 rs138709 chr22:39139216 C/G cg06544989 chr22:39130855 UNC84B 0.49 9.36 0.5 3.5e-18 Menopause (age at onset); CESC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg20573242 chr4:122745356 CCNA2 0.62 7.64 0.42 3.94e-13 Type 2 diabetes; CESC cis rs7666738 0.830 rs4441757 chr4:98927059 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg11843238 chr5:131593191 PDLIM4 0.36 5.33 0.31 2.14e-7 Breast cancer; CESC cis rs4253772 0.513 rs9615345 chr22:46713631 C/T cg18190219 chr22:46762943 CELSR1 -0.48 -6.12 -0.35 3.28e-9 LDL cholesterol;Cholesterol, total; CESC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg18876405 chr7:65276391 NA -0.49 -6.7 -0.38 1.27e-10 Aortic root size; CESC cis rs9487051 0.646 rs11153167 chr6:109622582 A/T cg01475377 chr6:109611718 NA 0.41 5.5 0.32 8.94e-8 Reticulocyte fraction of red cells; CESC cis rs17023223 0.509 rs7542832 chr1:119762729 T/C cg05756136 chr1:119680316 WARS2 -0.49 -5.97 -0.34 7.55e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07556773 chr1:155294010 RUSC1;C1orf104 -0.43 -6.01 -0.35 5.97e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4764487 0.685 rs740839 chr12:6338637 C/T cg08284733 chr12:6341482 CD9 0.42 6.18 0.36 2.38e-9 Mean platelet volume; CESC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg18876405 chr7:65276391 NA -0.52 -7.02 -0.4 1.83e-11 Aortic root size; CESC cis rs2985684 0.948 rs12886130 chr14:50082753 T/C cg02151108 chr14:50098012 C14orf104 -0.4 -5.21 -0.3 3.75e-7 Carotid intima media thickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14852625 chr3:127309519 TPRA1 0.69 8.06 0.44 2.66e-14 Gut microbiome composition (summer); CESC cis rs7937682 0.889 rs1789361 chr11:111485334 T/C cg09085632 chr11:111637200 PPP2R1B -0.95 -14.72 -0.67 3.1e-36 Primary sclerosing cholangitis; CESC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg03538708 chr1:25844672 NA -0.38 -5.52 -0.32 7.89e-8 Erythrocyte sedimentation rate; CESC cis rs3780486 0.629 rs10971439 chr9:33180813 C/T cg13443165 chr9:33130375 B4GALT1 -0.42 -5.05 -0.3 8.3e-7 IgG glycosylation; CESC cis rs17376456 0.877 rs12716457 chr5:93397627 T/C cg25358565 chr5:93447407 FAM172A 1.11 10.75 0.55 1.35e-22 Diabetic retinopathy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25282353 chr6:144416767 SF3B5 -0.46 -6.21 -0.36 2.01e-9 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14871650 chr4:170541668 CLCN3 -0.47 -6.1 -0.35 3.83e-9 Fibrinogen levels; CESC cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.45 0.32 1.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs870825 0.616 rs7694899 chr4:185625390 C/T cg04058563 chr4:185651563 MLF1IP 0.61 6.71 0.38 1.21e-10 Blood protein levels; CESC cis rs6665290 0.904 rs1186 chr1:227177731 A/T cg10327440 chr1:227177885 CDC42BPA -1.23 -34.55 -0.9 3.8e-100 Myeloid white cell count; CESC cis rs35110281 0.720 rs162375 chr21:44927015 C/T cg01579765 chr21:45077557 HSF2BP 0.52 9.02 0.48 3.87e-17 Mean corpuscular volume; CESC cis rs911555 0.755 rs8018400 chr14:103901085 A/G cg24130564 chr14:104152367 KLC1 0.5 6.62 0.38 2.02e-10 Intelligence (multi-trait analysis); CESC cis rs6541297 0.941 rs2144299 chr1:230280366 A/G cg20703242 chr1:230279135 GALNT2 0.66 9.34 0.5 4.12e-18 Coronary artery disease; CESC cis rs1256061 0.528 rs10143616 chr14:64740175 G/A cg23250157 chr14:64679961 SYNE2 0.37 5.05 0.3 8.39e-7 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9549367 0.789 rs9604040 chr13:113910611 A/G cg18105134 chr13:113819100 PROZ 0.62 7.75 0.43 1.91e-13 Platelet distribution width; CESC trans rs13098911 0.540 rs13075758 chr3:46025048 G/A cg10236987 chr1:228114221 WNT9A 0.6 6.17 0.35 2.61e-9 Celiac disease; CESC cis rs6998277 0.830 rs6468836 chr8:103602630 A/G cg10187029 chr8:103597600 NA 0.75 9.9 0.52 7.14e-20 Migraine; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01593421 chr7:65303149 NA -0.72 -8.83 -0.48 1.49e-16 Gut microbiome composition (summer); CESC cis rs1267303 0.642 rs2404611 chr1:46997127 C/G cg25110126 chr1:46999211 NA 0.92 10.3 0.53 3.79e-21 Monobrow; CESC cis rs7917772 0.503 rs1536308 chr10:104288777 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.33 0.41 2.81e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs796364 0.806 rs78037592 chr2:201105734 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.77 -6.33 -0.36 1.05e-9 Schizophrenia; CESC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.13e-10 Bipolar disorder; CESC cis rs1048238 0.506 rs848212 chr1:16263452 A/G cg21385522 chr1:16154831 NA -0.43 -5.47 -0.32 1.04e-7 Systolic blood pressure; CESC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg26314531 chr2:26401878 FAM59B -0.62 -7.01 -0.4 2.02e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.34 0.46 4.13e-15 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.863 rs6853998 chr4:120475860 C/A cg24375607 chr4:120327624 NA 0.45 5.51 0.32 8.55e-8 Corneal astigmatism; CESC cis rs2370759 1.000 rs75984055 chr10:32591276 T/C cg01819863 chr10:32635814 EPC1 1.16 13.25 0.63 4.48e-31 Sexual dysfunction (female); CESC cis rs11249608 0.548 rs2047354 chr5:178455247 T/C cg01312482 chr5:178451176 ZNF879 -0.46 -6.42 -0.37 6.42e-10 Pubertal anthropometrics; CESC cis rs4253772 0.530 rs11090875 chr22:46785301 C/T cg00784671 chr22:46762841 CELSR1 -0.59 -5.63 -0.33 4.66e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4835473 0.900 rs13140028 chr4:144703348 T/C cg25736465 chr4:144833511 NA -0.42 -6.42 -0.37 6.21e-10 Immature fraction of reticulocytes; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg15147215 chr3:52552868 STAB1 -0.37 -6.68 -0.38 1.39e-10 Electroencephalogram traits; CESC cis rs6565180 1.000 rs11646130 chr16:30376959 T/C cg17640201 chr16:30407289 ZNF48 -0.94 -13.81 -0.65 4.82e-33 Tonsillectomy; CESC trans rs9834373 0.573 rs9828144 chr3:78523315 T/G cg21593409 chr16:88706389 IL17C -0.42 -6.04 -0.35 5.2e-9 Protein quantitative trait loci; CESC cis rs12618769 0.597 rs3769730 chr2:99101453 T/C cg10123293 chr2:99228465 UNC50 0.39 5.14 0.3 5.22e-7 Bipolar disorder; CESC cis rs1775715 0.707 rs2808087 chr10:32146444 C/G cg18675610 chr10:32216311 ARHGAP12 0.34 5.4 0.31 1.47e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg17724175 chr1:150552817 MCL1 0.42 6.34 0.36 1e-9 Melanoma; CESC cis rs2115536 0.967 rs4778734 chr15:80210851 A/G cg00225070 chr15:80189496 MTHFS 0.54 7.38 0.41 2.05e-12 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10120645 chr8:125486635 RNF139 0.58 6.73 0.38 1.06e-10 Gut microbiome composition (summer); CESC cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg06212747 chr3:49208901 KLHDC8B 0.68 9.34 0.5 3.96e-18 Parkinson's disease; CESC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg08888203 chr3:10149979 C3orf24 -0.46 -6.07 -0.35 4.53e-9 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19924025 chr1:65720054 NA 0.62 7.16 0.4 8.03e-12 Gut microbiome composition (summer); CESC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg24060327 chr5:131705240 SLC22A5 -0.73 -9.78 -0.51 1.77e-19 Breast cancer; CESC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg22800045 chr5:56110881 MAP3K1 -0.66 -7.57 -0.42 6.14e-13 Initial pursuit acceleration; CESC cis rs61925898 1 rs61925898 chr12:66779537 A/G cg16791601 chr12:66731901 HELB -0.68 -11.17 -0.57 5.34e-24 Basophil percentage of granulocytes;Basophil percentage of white cells; CESC cis rs9868809 0.542 rs9873726 chr3:48712367 C/T cg03060546 chr3:49711283 APEH -0.63 -5.58 -0.32 5.98e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs1691799 0.899 rs1168315 chr12:66746694 A/G cg16791601 chr12:66731901 HELB -0.77 -13.71 -0.64 1.08e-32 White blood cell count (basophil); CESC cis rs3806843 1.000 rs11167600 chr5:140174865 G/C cg26395211 chr5:140044315 WDR55 -0.41 -5.18 -0.3 4.29e-7 Depressive symptoms (multi-trait analysis); CESC cis rs10504229 0.516 rs58244172 chr8:57987805 G/A cg22535103 chr8:58192502 C8orf71 -0.47 -5.88 -0.34 1.24e-8 Developmental language disorder (linguistic errors); CESC cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg04455712 chr21:45112962 RRP1B 0.47 7.35 0.41 2.53e-12 Mean corpuscular volume; CESC cis rs2635047 0.811 rs12957869 chr18:44786869 C/G cg24371990 chr18:44770781 NA 0.41 6.53 0.37 3.33e-10 Educational attainment; CESC cis rs7512552 0.809 rs696618 chr1:150376139 T/G cg15654264 chr1:150340011 RPRD2 0.39 5.13 0.3 5.65e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg05283184 chr6:79620031 NA -0.43 -6.5 -0.37 3.95e-10 Intelligence (multi-trait analysis); CESC cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg20503657 chr10:835505 NA 1.08 9.93 0.52 5.96e-20 Eosinophil percentage of granulocytes; CESC cis rs9815354 1.000 rs28733681 chr3:41863444 C/A cg03022575 chr3:42003672 ULK4 0.49 5.51 0.32 8.46e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs10887741 0.690 rs12781358 chr10:89444367 C/T cg13926569 chr10:89418898 PAPSS2 0.36 5.4 0.32 1.45e-7 Exercise (leisure time); CESC cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.74 8.81 0.48 1.73e-16 Age-related macular degeneration (geographic atrophy); CESC trans rs459571 0.920 rs460154 chr9:136909309 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.55 -7.2 -0.4 6.13e-12 Platelet distribution width; CESC cis rs1030877 0.515 rs1020064 chr2:105897740 T/G cg02079111 chr2:105885981 TGFBRAP1 0.49 6.51 0.37 3.66e-10 Obesity-related traits; CESC cis rs73001065 0.551 rs79954596 chr19:19548643 T/G cg03709012 chr19:19516395 GATAD2A 1.0 8.08 0.44 2.3e-14 LDL cholesterol; CESC cis rs9488822 0.702 rs6909746 chr6:116352750 C/T cg05304507 chr6:116381966 FRK 0.25 6.54 0.37 3.07e-10 Cholesterol, total;LDL cholesterol; CESC cis rs4722166 0.598 rs4722179 chr7:22803861 C/A cg05472934 chr7:22766657 IL6 0.42 5.77 0.33 2.23e-8 Lung cancer; CESC cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg24296786 chr1:45957014 TESK2 0.66 9.13 0.49 1.8e-17 High light scatter reticulocyte count; CESC cis rs7188697 0.922 rs7199856 chr16:58584772 A/C cg21335942 chr16:58549945 SETD6 0.46 5.6 0.33 5.33e-8 QT interval; CESC cis rs8067545 0.518 rs7222987 chr17:20055765 A/G cg13482628 chr17:19912719 NA 0.41 5.43 0.32 1.25e-7 Schizophrenia; CESC cis rs116095464 0.558 rs10052012 chr5:231908 T/C cg10591111 chr5:226296 SDHA -0.52 -6.37 -0.36 8.3e-10 Breast cancer; CESC cis rs9309473 0.861 rs6546857 chr2:73837955 A/G cg20560298 chr2:73613845 ALMS1 -0.49 -6.34 -0.36 9.96e-10 Metabolite levels; CESC cis rs6580649 0.831 rs1635528 chr12:48395900 C/T cg05342945 chr12:48394962 COL2A1 -0.52 -6.25 -0.36 1.65e-9 Lung cancer; CESC cis rs9287719 0.967 rs2884233 chr2:10745303 G/A cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC cis rs5771242 0.769 rs4838865 chr22:50664612 A/G cg08875078 chr22:50639485 SELO 0.62 7.05 0.4 1.58e-11 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00529053 chr6:158589440 GTF2H5;SERAC1 0.58 6.72 0.38 1.13e-10 Gut microbiome composition (summer); CESC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg01341218 chr17:43662625 NA 0.92 10.78 0.55 1.08e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg09699651 chr6:150184138 LRP11 0.4 5.13 0.3 5.5e-7 Lung cancer; CESC cis rs9837602 0.507 rs1059905 chr3:99516879 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.43 -7.04 -0.4 1.65e-11 Breast cancer; CESC cis rs7665939 0.929 rs13353755 chr4:190100646 T/C cg14840187 chr4:190284988 NA -0.64 -6.6 -0.38 2.28e-10 Amyotrophic lateral sclerosis; CESC cis rs7165102 1.000 rs352476 chr15:65805389 T/C cg11441148 chr15:65824328 PTPLAD1 -0.31 -5.27 -0.31 2.8e-7 Mean corpuscular hemoglobin; CESC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg12463550 chr7:65579703 CRCP -0.47 -6.08 -0.35 4.28e-9 Aortic root size; CESC cis rs1048238 0.506 rs7525608 chr1:16141901 A/G cg21385522 chr1:16154831 NA 0.44 5.63 0.33 4.69e-8 Systolic blood pressure; CESC cis rs2228479 0.850 rs2238532 chr16:89863672 T/C cg19635926 chr16:89946313 TCF25 0.67 5.05 0.3 8.42e-7 Skin colour saturation; CESC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg05872129 chr22:39784769 NA -0.82 -10.83 -0.55 6.99e-23 Intelligence (multi-trait analysis); CESC cis rs6076065 0.594 rs6048755 chr20:23337233 A/G cg11657817 chr20:23433608 CST11 0.4 6.02 0.35 5.91e-9 Facial morphology (factor 15, philtrum width); CESC cis rs2921036 0.545 rs4840975 chr8:8363258 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -5.19 -0.3 4.13e-7 Neuroticism; CESC cis rs7542091 0.739 rs10863793 chr1:210037420 G/A cg05527609 chr1:210001259 C1orf107 -0.45 -5.67 -0.33 3.75e-8 Monobrow; CESC cis rs11690961 0.778 rs6724315 chr2:46363699 T/C cg12428440 chr2:46370979 PRKCE 0.49 5.09 0.3 6.83e-7 Pulse pressure; CESC cis rs2191566 1.000 rs2191566 chr19:44511389 A/C cg20607764 chr19:44506953 ZNF230 0.57 7.39 0.41 1.95e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs11122272 0.735 rs2749704 chr1:231526243 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.78e-9 Hemoglobin concentration; CESC cis rs7916697 0.947 rs56238729 chr10:70001640 T/C cg06988349 chr10:69991859 ATOH7 0.39 6.38 0.37 7.68e-10 Optic disc area; CESC trans rs6089829 0.889 rs6122348 chr20:61663921 C/T cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs9894429 0.621 rs7502337 chr17:79588470 T/C cg13777783 chr17:79615861 NA -0.36 -5.99 -0.35 6.7e-9 Eye color traits; CESC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.53 5.94 0.34 9.08e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6570726 0.935 rs391524 chr6:145823844 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6831352 0.959 rs6848050 chr4:100053733 T/C cg12011299 chr4:100065546 ADH4 0.69 8.57 0.47 8.82e-16 Alcohol dependence; CESC cis rs853679 0.882 rs9468300 chr6:28126840 C/T cg18032046 chr6:28092343 ZSCAN16 -0.76 -6.55 -0.37 3.04e-10 Depression; CESC cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg00101154 chr16:420108 MRPL28 -0.43 -5.06 -0.3 7.89e-7 Bone mineral density (spine);Bone mineral density; CESC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg06108461 chr20:60628389 TAF4 -0.92 -14.55 -0.67 1.22e-35 Body mass index; CESC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg20151795 chr6:28129481 ZNF389 -0.42 -5.34 -0.31 2e-7 Parkinson's disease; CESC trans rs2727020 0.521 rs7131163 chr11:49574774 C/T cg03929089 chr4:120376271 NA -0.71 -8.18 -0.45 1.21e-14 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23207985 chr11:67034251 ADRBK1 -0.49 -6.97 -0.39 2.49e-11 Gambling; CESC cis rs9457247 0.765 rs10484531 chr6:167454434 G/A cg23791538 chr6:167370224 RNASET2 -0.55 -7.65 -0.43 3.82e-13 Crohn's disease; CESC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg26408565 chr15:76604113 ETFA -0.41 -6.01 -0.35 6.2e-9 Blood metabolite levels; CESC cis rs1499972 0.668 rs4146338 chr3:117493964 C/T cg07612923 chr3:117604196 NA -0.64 -5.96 -0.34 8.13e-9 Schizophrenia; CESC cis rs55823223 0.564 rs936391 chr17:73847799 A/G cg23806715 chr17:73775811 H3F3B -0.5 -5.76 -0.33 2.31e-8 Psoriasis; CESC cis rs6942756 1.000 rs4440569 chr7:128923907 T/A cg02491457 chr7:128862824 NA -0.68 -9.03 -0.49 3.55e-17 White matter hyperintensity burden; CESC cis rs1371867 0.846 rs1660329 chr8:101304048 G/T cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.24e-11 Atrioventricular conduction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12736146 chr10:116391608 ABLIM1 -0.56 -6.73 -0.38 1.03e-10 Gut microbiome composition (summer); CESC cis rs2463822 0.583 rs72919467 chr11:62040102 G/A cg06239285 chr11:62104954 ASRGL1 -1.06 -8.65 -0.47 4.87e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg12564285 chr5:131593104 PDLIM4 0.38 5.69 0.33 3.4e-8 Breast cancer; CESC cis rs1832871 0.672 rs111782080 chr6:158765385 G/A cg07165851 chr6:158734300 TULP4 0.58 6.18 0.36 2.36e-9 Height; CESC cis rs7923609 0.846 rs10740116 chr10:65094992 T/C cg01631684 chr10:65280961 REEP3 -0.42 -5.26 -0.31 3.04e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs72781680 1.000 rs72781649 chr2:24210864 A/G cg20701182 chr2:24300061 SF3B14 0.63 5.58 0.32 6.04e-8 Lymphocyte counts; CESC cis rs965469 1.000 rs6051753 chr20:3315513 G/A cg25506879 chr20:3388711 C20orf194 -0.53 -5.8 -0.34 1.84e-8 IFN-related cytopenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09166705 chr1:151170883 PIP5K1A 0.53 6.05 0.35 4.91e-9 Gut microbiome composition (summer); CESC cis rs1538970 0.962 rs9429077 chr1:45820667 C/A cg06784218 chr1:46089804 CCDC17 0.31 5.15 0.3 5.19e-7 Platelet count; CESC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg11764359 chr7:65958608 NA 0.8 9.71 0.51 2.85e-19 Aortic root size; CESC cis rs2932538 0.922 rs12739994 chr1:113131159 T/C cg22162597 chr1:113214053 CAPZA1 0.6 6.99 0.39 2.26e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg20891558 chr2:74357851 NA 0.76 10.0 0.52 3.55e-20 Gestational age at birth (maternal effect); CESC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg11890956 chr21:40555474 PSMG1 1.15 21.07 0.79 1.46e-58 Cognitive function; CESC trans rs72766638 0.806 rs56303154 chr9:136936376 C/T cg10765909 chr12:53715428 AAAS -0.7 -6.18 -0.35 2.37e-9 Mosquito bite size; CESC cis rs6502050 0.830 rs8074436 chr17:80158422 A/G cg23985595 chr17:80112537 CCDC57 -0.39 -6.24 -0.36 1.76e-9 Life satisfaction; CESC cis rs12586317 0.547 rs2254990 chr14:35465565 T/C cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC cis rs9291683 0.588 rs4697705 chr4:10108127 G/A cg00071950 chr4:10020882 SLC2A9 -0.55 -8.53 -0.46 1.17e-15 Bone mineral density; CESC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg17221315 chr6:27791827 HIST1H4J 0.44 5.78 0.33 2.06e-8 Cardiac Troponin-T levels; CESC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.64 -0.38 1.72e-10 Life satisfaction; CESC cis rs698833 0.962 rs786409 chr2:44731344 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.56 6.89 0.39 3.97e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs5769765 0.913 rs8135071 chr22:50299587 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.49 -5.54 -0.32 7.17e-8 Schizophrenia; CESC cis rs6570726 0.935 rs406343 chr6:145874388 A/G cg23711669 chr6:146136114 FBXO30 0.8 11.82 0.59 3.5e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs2425143 0.818 rs11700299 chr20:34548865 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.58 0.32 5.8e-8 Blood protein levels; CESC cis rs4718428 0.672 rs12530806 chr7:66390724 A/G cg25985355 chr7:65971099 NA -0.34 -5.07 -0.3 7.49e-7 Corneal structure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10557139 chr6:43507079 XPO5 -0.62 -7.48 -0.42 1.1e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16248618 chr11:65819774 SF3B2 0.56 6.1 0.35 3.79e-9 Gut microbiome composition (summer); CESC cis rs796364 0.664 rs3106089 chr2:200884615 A/C cg23649088 chr2:200775458 C2orf69 0.6 5.41 0.32 1.43e-7 Schizophrenia; CESC cis rs113835537 0.597 rs7939759 chr11:66337964 C/T cg22134325 chr11:66188745 NPAS4 0.37 5.56 0.32 6.61e-8 Airway imaging phenotypes; CESC trans rs11098499 0.954 rs6846442 chr4:120326323 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs2777491 0.574 rs72739644 chr15:41719706 A/G cg20272979 chr15:41787780 ITPKA 0.42 5.14 0.3 5.47e-7 Ulcerative colitis; CESC cis rs7408868 1.000 rs10422818 chr19:15285272 A/G cg14696996 chr19:15285081 NOTCH3 1.05 11.0 0.56 1.94e-23 Pulse pressure; CESC cis rs1864400 0.696 rs2742239 chr10:43621712 A/G cg07801480 chr10:43725741 RASGEF1A 0.4 5.2 0.3 4e-7 Hirschsprung disease; CESC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg25072359 chr17:41440525 NA 0.43 5.83 0.34 1.61e-8 Menopause (age at onset); CESC cis rs7208859 0.623 rs3794796 chr17:29130880 G/C cg13385521 chr17:29058706 SUZ12P 0.84 6.62 0.38 1.98e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1728785 1.000 rs4783656 chr16:68580722 C/T cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs72634258 0.786 rs7537362 chr1:8177564 C/T cg00042356 chr1:8021962 PARK7 0.57 6.04 0.35 5.32e-9 Inflammatory bowel disease; CESC cis rs148803332 1 rs148803332 chr17:65958250 CAAAAGAAA/C cg07042672 chr17:66097459 LOC651250 0.62 7.53 0.42 7.95e-13 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes; CESC cis rs3008870 1.000 rs12039172 chr1:67447450 A/G cg02640540 chr1:67518911 SLC35D1 -0.52 -5.59 -0.33 5.5e-8 Lymphocyte percentage of white cells; CESC cis rs6582630 0.555 rs11182429 chr12:38526679 A/C cg13010199 chr12:38710504 ALG10B 0.45 5.97 0.34 7.47e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs654950 0.806 rs2759251 chr1:42041749 C/G cg06885757 chr1:42089581 HIVEP3 -0.64 -10.14 -0.53 1.22e-20 Airway imaging phenotypes; CESC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg12311346 chr5:56204834 C5orf35 -0.74 -8.85 -0.48 1.25e-16 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20564664 chr21:37432585 SETD4 0.59 6.33 0.36 1.05e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg26338869 chr17:61819248 STRADA 0.68 8.89 0.48 9.5e-17 Prudent dietary pattern; CESC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC cis rs4474465 0.646 rs6592794 chr11:78275743 A/G cg27205649 chr11:78285834 NARS2 0.46 6.04 0.35 5.25e-9 Alzheimer's disease (survival time); CESC cis rs12142240 0.738 rs17361749 chr1:46806480 C/T cg10495392 chr1:46806563 NSUN4 0.59 6.36 0.36 8.9e-10 Menopause (age at onset); CESC cis rs9354352 0.818 rs9453548 chr6:66691885 T/C cg07460842 chr6:66804631 NA -0.64 -9.24 -0.49 8.55e-18 Initial pursuit acceleration in psychotic disorders; CESC cis rs1580019 0.713 rs2122632 chr7:32524686 A/G cg07520158 chr7:32535189 LSM5;AVL9 -0.51 -6.36 -0.36 8.68e-10 Cognitive ability; CESC cis rs10423674 0.526 rs2023878 chr19:18834124 A/G cg14292368 chr19:18793705 CRTC1 0.4 5.12 0.3 5.76e-7 Menarche (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04742505 chr7:72936528 BAZ1B 0.47 6.02 0.35 5.64e-9 Gut microbiota (bacterial taxa); CESC cis rs4253772 0.515 rs9615969 chr22:46773592 C/G cg18190219 chr22:46762943 CELSR1 -0.67 -5.58 -0.32 6.05e-8 LDL cholesterol;Cholesterol, total; CESC cis rs2404602 0.692 rs35170561 chr15:77130695 C/T cg26408565 chr15:76604113 ETFA -0.37 -5.43 -0.32 1.26e-7 Blood metabolite levels; CESC cis rs2276314 0.857 rs28791905 chr18:33602213 G/A cg19628046 chr18:33552617 C18orf21 0.48 5.2 0.3 4.06e-7 Endometriosis;Drug-induced torsades de pointes; CESC cis rs2270431 1 rs2270431 chr14:75270635 T/C cg11812906 chr14:75593930 NEK9 0.42 5.19 0.3 4.11e-7 Neuroticism; CESC cis rs7917772 0.503 rs7904955 chr10:104367092 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.47 5.48 0.32 9.73e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2635047 0.512 rs9962436 chr18:44599109 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 7.53 0.42 7.88e-13 Educational attainment; CESC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg17372223 chr3:52568218 NT5DC2 0.43 6.47 0.37 4.6e-10 Bipolar disorder; CESC cis rs9790314 0.875 rs336580 chr3:161082982 A/T cg04691961 chr3:161091175 C3orf57 -0.39 -5.08 -0.3 7.17e-7 Morning vs. evening chronotype; CESC trans rs10028773 0.666 rs35231872 chr4:120248376 A/T cg25214090 chr10:38739885 LOC399744 0.62 8.36 0.46 3.48e-15 Educational attainment; CESC cis rs1355223 0.902 rs1453387 chr11:34707898 C/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.43 -0.37 5.95e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2988277 0.737 rs1723015 chr1:167432894 T/C cg09179987 chr1:167433047 CD247 0.46 6.99 0.39 2.19e-11 Allergic disease (asthma, hay fever or eczema); CESC cis rs2011503 1.000 rs2965194 chr19:19460702 C/T cg11584989 chr19:19387371 SF4 -0.65 -7.81 -0.43 1.35e-13 Bipolar disorder; CESC cis rs7833986 0.501 rs2667999 chr8:56950474 T/C cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.16 0.3 4.9e-7 Height; CESC trans rs9325144 0.647 rs11168819 chr12:39011082 C/A cg23762105 chr12:34175262 ALG10 0.48 6.41 0.37 6.45e-10 Morning vs. evening chronotype; CESC cis rs7116495 0.609 rs2511120 chr11:71786211 C/T cg18441811 chr11:71824068 C11orf51 -0.83 -5.18 -0.3 4.47e-7 Severe influenza A (H1N1) infection; CESC cis rs796364 0.951 rs7586320 chr2:201068209 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.61 5.71 0.33 3.07e-8 Schizophrenia; CESC trans rs5756813 0.727 rs58765732 chr22:38160794 A/C cg19894588 chr14:64061835 NA -0.69 -8.63 -0.47 5.6e-16 Optic cup area;Vertical cup-disc ratio; CESC cis rs11190604 1.000 rs2489040 chr10:102331298 G/A cg07080220 chr10:102295463 HIF1AN 0.56 5.36 0.31 1.77e-7 Palmitoleic acid (16:1n-7) levels; CESC trans rs17767392 0.748 rs55896578 chr14:71712185 G/A cg23339363 chr7:44261644 CAMK2B 0.43 6.14 0.35 3.04e-9 Mitral valve prolapse; CESC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg16405210 chr4:1374714 KIAA1530 0.44 5.47 0.32 1.06e-7 Obesity-related traits; CESC trans rs2207136 0.835 rs3846904 chr6:50872761 C/T cg06522515 chr3:184090630 THPO -0.36 -6.24 -0.36 1.69e-9 Myopia; CESC cis rs9287719 0.967 rs4669596 chr2:10720572 C/T cg02196655 chr2:10830764 NOL10 -0.36 -5.63 -0.33 4.63e-8 Prostate cancer; CESC cis rs9287719 0.967 rs4453662 chr2:10739128 G/A cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs8017423 0.967 rs2277516 chr14:90722824 G/C cg14092571 chr14:90743983 NA -0.55 -8.31 -0.45 5.06e-15 Mortality in heart failure; CESC cis rs11997175 0.646 rs12678266 chr8:33689254 A/G ch.8.33884649F chr8:33765107 NA 0.56 7.37 0.41 2.13e-12 Body mass index; CESC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg06494592 chr3:125709126 NA -0.51 -5.91 -0.34 1.07e-8 Blood pressure (smoking interaction); CESC cis rs4589502 0.920 rs77518050 chr15:67138089 T/C cg12317470 chr15:67143691 NA 0.68 5.32 0.31 2.18e-7 Lung cancer (smoking interaction); CESC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg12379764 chr21:47803548 PCNT -0.46 -5.86 -0.34 1.39e-8 Testicular germ cell tumor; CESC cis rs3916 0.641 rs7964786 chr12:121132100 C/T cg26008908 chr12:120799332 MSI1 0.38 6.11 0.35 3.5e-9 Urinary metabolites (H-NMR features); CESC cis rs748404 0.534 rs489509 chr15:43586907 T/A cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.8 0.43 1.4e-13 Lung cancer; CESC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 9.8 0.52 1.52e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4803468 1.000 rs2288871 chr19:41917868 C/T cg14132834 chr19:41945861 ATP5SL -0.58 -7.23 -0.41 5.22e-12 Height; CESC cis rs1215050 0.874 rs2167893 chr4:99048464 A/T cg05340658 chr4:99064831 C4orf37 0.55 6.81 0.39 6.48e-11 Waist-to-hip ratio adjusted for body mass index; CESC trans rs2727020 0.681 rs1976901 chr11:49378697 T/C cg15704280 chr7:45808275 SEPT13 -0.87 -14.47 -0.66 2.28e-35 Coronary artery disease; CESC cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg20307385 chr11:47447363 PSMC3 -0.64 -7.63 -0.42 4.21e-13 Subjective well-being; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg08259472 chr6:43603507 MAD2L1BP 0.49 6.02 0.35 5.65e-9 Psoriatic arthritis; CESC cis rs5753618 0.555 rs5749286 chr22:31900359 G/T cg00478049 chr22:31556069 RNF185 -0.46 -5.53 -0.32 7.68e-8 Colorectal cancer; CESC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg26335602 chr6:28129616 ZNF389 0.54 7.25 0.41 4.45e-12 Depression; CESC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg26338869 chr17:61819248 STRADA 0.68 8.94 0.48 6.9e-17 Prudent dietary pattern; CESC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg12564285 chr5:131593104 PDLIM4 0.41 6.39 0.37 7.3e-10 Acylcarnitine levels; CESC cis rs853679 1.000 rs68141011 chr6:28217797 G/T cg12740337 chr6:28058973 ZSCAN12L1 0.32 5.03 0.3 9.18e-7 Depression; CESC cis rs2425143 1.000 rs6060591 chr20:34351476 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.72 6.82 0.39 6.12e-11 Blood protein levels; CESC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 11.53 0.58 3.49e-25 Personality dimensions; CESC cis rs12893668 0.667 rs71417869 chr14:104077434 A/G cg08213375 chr14:104286397 PPP1R13B 0.33 5.21 0.3 3.76e-7 Reticulocyte count; CESC trans rs1814175 0.817 rs7924619 chr11:49620632 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -19.21 -0.76 3.92e-52 Height; CESC cis rs7772486 0.754 rs9497434 chr6:146260753 C/T cg23711669 chr6:146136114 FBXO30 -0.94 -13.66 -0.64 1.66e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg14345882 chr6:26364793 BTN3A2 0.41 5.35 0.31 1.94e-7 Intelligence (multi-trait analysis); CESC cis rs763121 0.853 rs5750633 chr22:38993467 A/G cg21395723 chr22:39101663 GTPBP1 0.51 6.82 0.39 6.01e-11 Menopause (age at onset); CESC trans rs7726839 0.540 rs72705102 chr5:659437 T/C cg25482853 chr8:67687455 SGK3 1.02 10.32 0.54 3.29e-21 Obesity-related traits; CESC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg22907277 chr7:1156413 C7orf50 0.39 5.66 0.33 3.92e-8 Longevity;Endometriosis; CESC cis rs7568458 0.709 rs2043675 chr2:85769975 C/T cg02493740 chr2:85810744 VAMP5 0.55 8.12 0.45 1.8e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9486719 0.843 rs2472876 chr6:96845723 A/G cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg07507251 chr3:52567010 NT5DC2 0.45 8.52 0.46 1.19e-15 Electroencephalogram traits; CESC cis rs4689388 0.926 rs4689391 chr4:6280449 G/A cg25554036 chr4:6271136 WFS1 0.56 9.36 0.5 3.62e-18 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6424115 0.708 rs2076343 chr1:24129126 A/G cg15997130 chr1:24165203 NA -0.44 -5.39 -0.31 1.57e-7 Immature fraction of reticulocytes; CESC trans rs7839040 0.698 rs1507096 chr8:82927443 C/T cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg16545954 chr1:2118288 C1orf86 -0.31 -5.86 -0.34 1.34e-8 Height; CESC cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg26597838 chr10:835615 NA 0.7 6.53 0.37 3.31e-10 Eosinophil percentage of granulocytes; CESC cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg03709012 chr19:19516395 GATAD2A 0.96 14.14 0.66 3.35e-34 Tonsillectomy; CESC cis rs6456156 0.586 rs1358883 chr6:167467433 C/G cg23791538 chr6:167370224 RNASET2 0.52 6.71 0.38 1.16e-10 Primary biliary cholangitis; CESC cis rs6460942 0.597 rs35317839 chr7:12524397 C/A cg06484146 chr7:12443880 VWDE -0.71 -7.69 -0.43 2.88e-13 Coronary artery disease; CESC cis rs6693567 0.545 rs9436009 chr1:150459426 T/A cg09579323 chr1:150459698 TARS2 0.48 5.88 0.34 1.21e-8 Migraine; CESC cis rs2439831 0.867 rs2245715 chr15:43818052 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.77 8.39 0.46 3.02e-15 Lung cancer in ever smokers; CESC cis rs12822507 0.732 rs10845596 chr12:12780390 T/C cg11838227 chr12:12764436 CREBL2 0.42 5.63 0.33 4.59e-8 Systemic lupus erythematosus; CESC cis rs11098499 1.000 rs58601355 chr4:120186367 T/C cg09307838 chr4:120376055 NA 0.89 11.77 0.59 5.26e-26 Corneal astigmatism; CESC cis rs765787 0.530 rs11636404 chr15:45535861 C/G cg24006582 chr15:45444508 DUOX1 -0.55 -6.82 -0.39 6.05e-11 Uric acid levels; CESC cis rs926938 0.527 rs360594 chr1:115472401 G/A cg12756093 chr1:115239321 AMPD1 0.45 6.18 0.35 2.44e-9 Autism; CESC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg04944784 chr2:26401820 FAM59B -0.8 -8.93 -0.48 7.17e-17 Gut microbiome composition (summer); CESC cis rs2742234 0.955 rs2503841 chr10:43675721 C/T cg15436174 chr10:43711423 RASGEF1A -0.39 -5.1 -0.3 6.62e-7 Hirschsprung disease; CESC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg10523679 chr1:76189770 ACADM 0.55 5.33 0.31 2.13e-7 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3820068 0.581 rs72645864 chr1:15921153 C/T cg13390004 chr1:15929781 NA 0.33 5.04 0.3 8.45e-7 Systolic blood pressure; CESC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg21984481 chr17:79567631 NPLOC4 0.49 8.04 0.44 2.97e-14 Eye color traits; CESC cis rs10089 1.000 rs10061367 chr5:127449021 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.85 0.55 6.27e-23 Ileal carcinoids; CESC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg18876405 chr7:65276391 NA -0.51 -7.03 -0.4 1.8e-11 Aortic root size; CESC cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg17366294 chr4:99064904 C4orf37 0.57 7.94 0.44 5.82e-14 Colonoscopy-negative controls vs population controls; CESC trans rs9329221 0.935 rs3750311 chr8:10283602 C/A cg17143192 chr8:8559678 CLDN23 -0.56 -6.3 -0.36 1.2e-9 Neuroticism; CESC cis rs2880765 0.805 rs34598679 chr15:86042205 G/A cg19183879 chr15:85880815 NA -0.26 -5.38 -0.31 1.67e-7 Coronary artery disease; CESC cis rs61931739 0.500 rs34997501 chr12:34549828 C/G cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg04756594 chr16:24857601 SLC5A11 0.45 5.52 0.32 8.21e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7829975 0.846 rs1879957 chr8:8544808 T/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.54 -0.37 3.11e-10 Mood instability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01281426 chr5:180618016 NA -0.75 -9.07 -0.49 2.81e-17 Gut microbiome composition (summer); CESC cis rs6087771 0.851 rs6087775 chr20:30325765 G/A cg13852791 chr20:30311386 BCL2L1 0.81 10.36 0.54 2.4e-21 Subcortical brain region volumes;Putamen volume; CESC cis rs6754311 0.731 rs12988076 chr2:136569848 C/A cg07169764 chr2:136633963 MCM6 -0.66 -7.98 -0.44 4.39e-14 Mosquito bite size; CESC cis rs17431357 1.000 rs73221381 chr12:120913895 G/A cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs9372253 1.000 rs9384740 chr6:110716207 G/A cg19196401 chr6:110721138 DDO -0.39 -5.65 -0.33 4.06e-8 Platelet distribution width; CESC cis rs7165102 1.000 rs2456009 chr15:65840082 C/A cg11441148 chr15:65824328 PTPLAD1 -0.32 -5.39 -0.31 1.54e-7 Mean corpuscular hemoglobin; CESC cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg11752832 chr7:134001865 SLC35B4 0.52 6.69 0.38 1.33e-10 Mean platelet volume; CESC cis rs870825 0.860 rs72703526 chr4:185605676 A/T cg04058563 chr4:185651563 MLF1IP 0.54 5.24 0.31 3.27e-7 Blood protein levels; CESC cis rs2637266 1.000 rs12774835 chr10:78352226 C/G cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs1483890 0.642 rs1843049 chr3:69404078 T/C cg22125112 chr3:69402811 FRMD4B 0.39 5.34 0.31 1.98e-7 Resting heart rate; CESC cis rs6088580 0.634 rs1205334 chr20:32930369 T/C cg06115741 chr20:33292138 TP53INP2 -0.45 -5.72 -0.33 2.87e-8 Glomerular filtration rate (creatinine); CESC trans rs561341 1.000 rs111454793 chr17:30319267 T/C cg27661571 chr11:113659931 NA -0.83 -7.7 -0.43 2.79e-13 Hip circumference adjusted for BMI; CESC cis rs963731 0.649 rs77498284 chr2:39349726 C/A cg04010122 chr2:39346883 SOS1 0.73 5.17 0.3 4.6e-7 Corticobasal degeneration; CESC cis rs889312 0.500 rs185219 chr5:56136492 A/G cg14703610 chr5:56206110 C5orf35 0.5 6.63 0.38 1.84e-10 Breast cancer;Breast cancer (early onset); CESC cis rs9649465 0.561 rs2429621 chr7:123430316 A/G cg03229431 chr7:123269106 ASB15 0.4 5.52 0.32 8.08e-8 Migraine; CESC cis rs11190604 1.000 rs2489049 chr10:102350732 G/A cg07080220 chr10:102295463 HIF1AN 0.54 5.34 0.31 2.03e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs524281 0.692 rs2452681 chr11:65814842 G/A cg14036092 chr11:66035641 RAB1B 0.43 5.07 0.3 7.33e-7 Electroencephalogram traits; CESC trans rs10411161 0.702 rs11879319 chr19:52389592 C/T cg22319618 chr22:45562946 NUP50 -0.7 -7.06 -0.4 1.47e-11 Breast cancer; CESC cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg02574844 chr11:5959923 NA -0.44 -5.53 -0.32 7.81e-8 DNA methylation (variation); CESC cis rs2985684 0.894 rs2281837 chr14:50065359 C/G cg02151108 chr14:50098012 C14orf104 -0.38 -5.04 -0.3 8.58e-7 Carotid intima media thickness; CESC cis rs7772486 0.905 rs9373486 chr6:146446024 C/G cg05347473 chr6:146136440 FBXO30 -0.48 -6.22 -0.36 1.88e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs929354 1.000 rs1182377 chr7:157048403 T/C cg05182265 chr7:156933206 UBE3C 0.44 6.06 0.35 4.69e-9 Body mass index; CESC trans rs6677604 1.000 rs35253683 chr1:196704039 G/A cg02859443 chr16:53737878 RPGRIP1L;FTO -0.65 -6.2 -0.36 2.21e-9 IgA nephropathy;Nephropathy;Blood protein levels; CESC cis rs2072732 0.904 rs2981857 chr1:2971521 T/C cg15211996 chr1:2936768 ACTRT2 0.33 5.98 0.34 7.26e-9 Plateletcrit; CESC cis rs1950626 0.623 rs66722144 chr14:101457434 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.67 8.97 0.48 5.38e-17 Pelvic organ prolapse (moderate/severe); CESC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.27 0.6 1.07e-27 Alzheimer's disease; CESC cis rs9911578 1.000 rs999431 chr17:56854441 A/G cg05425664 chr17:57184151 TRIM37 -0.47 -6.5 -0.37 4.06e-10 Intelligence (multi-trait analysis); CESC cis rs9649465 0.935 rs7780086 chr7:123378471 C/A cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.46e-7 Migraine; CESC cis rs1292059 1 rs1292059 chr17:57957888 T/A cg13753209 chr17:57696993 CLTC 0.54 5.83 0.34 1.59e-8 Eosinophil percentage of granulocytes; CESC cis rs1915919 0.794 rs12488378 chr3:20022495 C/G cg05072819 chr3:20081367 KAT2B 0.44 6.3 0.36 1.21e-9 Post-traumatic stress disorder; CESC cis rs8016982 0.674 rs1951615 chr14:81671762 G/A cg01989461 chr14:81687754 GTF2A1 0.74 11.57 0.58 2.49e-25 Schizophrenia; CESC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg08470875 chr2:26401718 FAM59B 0.74 7.93 0.44 6.22e-14 Gut microbiome composition (summer); CESC trans rs61931739 0.892 rs73309466 chr12:34093146 A/G cg26384229 chr12:38710491 ALG10B -0.47 -6.56 -0.37 2.76e-10 Morning vs. evening chronotype; CESC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03576123 chr11:487126 PTDSS2 -1.08 -11.26 -0.57 2.77e-24 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02738677 chr3:133265129 NA -0.72 -8.4 -0.46 2.67e-15 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg25072359 chr17:41440525 NA 0.43 5.83 0.34 1.61e-8 Menopause (age at onset); CESC cis rs17401966 1.000 rs17410793 chr1:10391886 A/G cg15208524 chr1:10270712 KIF1B 0.49 6.25 0.36 1.65e-9 Hepatocellular carcinoma; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg19624444 chr7:2048497 MAD1L1 0.34 6.02 0.35 5.77e-9 Breast cancer; CESC cis rs7927771 0.524 rs10838775 chr11:47856382 C/G cg20307385 chr11:47447363 PSMC3 0.62 8.68 0.47 4.02e-16 Subjective well-being; CESC cis rs631288 0.793 rs6667498 chr1:146708029 C/G cg25205988 chr1:146714368 CHD1L -0.86 -5.13 -0.3 5.58e-7 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs4523957 0.614 rs7212964 chr17:2059319 C/T cg16513277 chr17:2031491 SMG6 -0.72 -10.2 -0.53 8.12e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7584330 0.780 rs7582828 chr2:238378476 A/C cg14458575 chr2:238380390 NA -0.69 -10.11 -0.53 1.57e-20 Prostate cancer; CESC trans rs1814175 0.645 rs1851845 chr11:49982396 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01148786 chr3:97540262 NA 0.45 6.06 0.35 4.63e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3857067 0.806 rs4693001 chr4:95115097 A/G cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC cis rs9325144 0.555 rs4882359 chr12:38726679 T/C cg26384229 chr12:38710491 ALG10B 0.56 7.99 0.44 4.24e-14 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08680260 chr22:31298152 OSBP2 0.42 6.4 0.37 6.88e-10 Gambling; CESC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg05552183 chr6:42928497 GNMT 0.83 14.06 0.65 6.26e-34 Alzheimer's disease in APOE e4+ carriers; CESC cis rs6460942 0.908 rs77894875 chr7:12248257 T/C cg20607287 chr7:12443886 VWDE -0.64 -6.37 -0.36 8.3e-10 Coronary artery disease; CESC cis rs17376456 0.778 rs10440717 chr5:93424852 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.33 0.31 2.12e-7 Diabetic retinopathy; CESC cis rs6736093 0.966 rs74182850 chr2:112681337 C/T cg12686935 chr2:112915763 FBLN7 -0.43 -5.56 -0.32 6.75e-8 Coronary artery disease; CESC cis rs42648 0.902 rs17874789 chr7:90001160 A/T cg23697855 chr7:89950296 NA -0.28 -5.38 -0.31 1.66e-7 Homocysteine levels; CESC cis rs17253792 0.822 rs77250916 chr14:56042208 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.73 0.33 2.76e-8 Putamen volume; CESC trans rs3942852 0.955 rs6485809 chr11:48112468 C/T cg03929089 chr4:120376271 NA -0.58 -6.12 -0.35 3.43e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg05340658 chr4:99064831 C4orf37 0.65 8.54 0.46 1.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.846 rs55770503 chr2:24030126 A/T cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC trans rs11098499 0.866 rs12513310 chr4:120288039 T/A cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs12142240 0.667 rs55887761 chr1:46826587 C/A cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg05340658 chr4:99064831 C4orf37 0.79 12.32 0.6 7.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs71277158 0.624 rs61493476 chr3:169887831 C/A cg04067573 chr3:169899625 PHC3 0.7 6.85 0.39 5.01e-11 Prostate cancer; CESC cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 12.73 0.62 2.85e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9467711 0.606 rs2073529 chr6:26375159 C/T cg12826209 chr6:26865740 GUSBL1 -0.67 -5.29 -0.31 2.59e-7 Autism spectrum disorder or schizophrenia; CESC cis rs2486288 0.656 rs12440356 chr15:45567529 T/C cg09092052 chr15:45571596 NA -0.51 -5.92 -0.34 9.94e-9 Glomerular filtration rate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14455541 chr20:49203350 FAM65C 0.46 6.35 0.36 9.17e-10 Fibrinogen levels; CESC cis rs228437 0.913 rs73554512 chr6:134941513 G/A cg24504307 chr6:134963096 NA -0.57 -6.06 -0.35 4.76e-9 Melanoma; CESC cis rs56235845 0.694 rs6876677 chr5:176755342 T/C cg06060754 chr5:176797920 RGS14 0.44 5.63 0.33 4.68e-8 Hemoglobin concentration;Hematocrit; CESC cis rs1707322 1.000 rs1707303 chr1:46598273 A/C cg06784218 chr1:46089804 CCDC17 -0.36 -5.83 -0.34 1.61e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg04267008 chr7:1944627 MAD1L1 -0.5 -5.86 -0.34 1.34e-8 Bipolar disorder and schizophrenia; CESC cis rs826838 0.586 rs10880753 chr12:38628147 C/A cg26384229 chr12:38710491 ALG10B -0.44 -5.93 -0.34 9.67e-9 Heart rate; CESC cis rs7551222 0.749 rs6682208 chr1:204566183 T/C cg20240347 chr1:204465584 NA -0.26 -5.39 -0.31 1.57e-7 Schizophrenia; CESC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg01097406 chr16:89675127 NA 0.37 5.28 0.31 2.69e-7 Vitiligo; CESC cis rs7267979 0.932 rs372678 chr20:25465248 G/A cg08601574 chr20:25228251 PYGB 0.36 5.28 0.31 2.76e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 18.47 0.75 1.61e-49 Prudent dietary pattern; CESC cis rs76878669 0.561 rs12420203 chr11:66163794 T/C cg18002602 chr11:66138449 SLC29A2 0.39 6.41 0.37 6.45e-10 Educational attainment (years of education); CESC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg18099408 chr3:52552593 STAB1 -0.33 -5.47 -0.32 1.02e-7 Bipolar disorder; CESC cis rs4242434 0.927 rs11778693 chr8:22462852 T/C cg03733263 chr8:22462867 KIAA1967 0.95 15.08 0.68 1.64e-37 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs6032067 0.929 rs13039108 chr20:43829584 T/C cg10761708 chr20:43804764 PI3 0.52 6.3 0.36 1.27e-9 Blood protein levels; CESC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg26939375 chr7:64535504 NA 0.71 9.75 0.51 2.13e-19 Aortic root size; CESC cis rs459571 0.920 rs460154 chr9:136909309 C/T cg13789015 chr9:136890014 NCRNA00094 0.51 7.4 0.41 1.86e-12 Platelet distribution width; CESC cis rs4974559 0.739 rs28444605 chr4:1290281 C/A cg02980000 chr4:1222292 CTBP1 0.81 7.39 0.41 1.88e-12 Systolic blood pressure; CESC trans rs6084875 0.686 rs2065035 chr20:4718398 C/T cg10192164 chr16:30419175 ZNF771 -0.5 -6.07 -0.35 4.38e-9 Systemic lupus erythematosus; CESC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg16049864 chr8:95962084 TP53INP1 -0.68 -12.13 -0.6 3.14e-27 Type 2 diabetes; CESC cis rs4889855 0.530 rs8079792 chr17:78609394 A/G cg16591659 chr17:78472290 NA -0.34 -5.49 -0.32 9.53e-8 Fractional excretion of uric acid; CESC cis rs34779708 0.931 rs13377158 chr10:35370465 A/C cg04310649 chr10:35416472 CREM 0.52 6.5 0.37 3.96e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs7772486 0.875 rs1331645 chr6:146398407 C/G cg05347473 chr6:146136440 FBXO30 0.48 6.5 0.37 4.01e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs561341 0.941 rs8066156 chr17:30361629 A/G cg27661571 chr11:113659931 NA -0.61 -6.43 -0.37 5.84e-10 Hip circumference adjusted for BMI; CESC cis rs17490626 0.533 rs5030925 chr10:71211150 A/C cg12610070 chr10:71211762 TSPAN15 -0.32 -6.87 -0.39 4.44e-11 Thrombosis; CESC cis rs73071352 0.588 rs55744136 chr3:41812293 A/C cg03022575 chr3:42003672 ULK4 0.7 6.17 0.35 2.5e-9 Multiple myeloma and monoclonal gammopathy;Multiple myeloma; CESC cis rs459571 0.959 rs456205 chr9:136911146 G/A cg13789015 chr9:136890014 NCRNA00094 0.57 8.06 0.44 2.59e-14 Platelet distribution width; CESC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg16325326 chr1:53192061 ZYG11B -1.01 -17.88 -0.74 1.89e-47 Monocyte count; CESC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.54 -0.37 3.08e-10 Total body bone mineral density; CESC cis rs11792861 0.816 rs72607157 chr9:111748001 T/G cg05043794 chr9:111880884 C9orf5 -0.37 -5.93 -0.34 9.17e-9 Menarche (age at onset); CESC cis rs5753618 0.583 rs738657 chr22:31841749 T/A cg02404636 chr22:31891804 SFI1 0.43 6.01 0.35 6.08e-9 Colorectal cancer; CESC cis rs116095464 0.558 rs7725227 chr5:233517 G/A cg22496380 chr5:211416 CCDC127 -0.75 -8.74 -0.47 2.64e-16 Breast cancer; CESC cis rs17376456 0.825 rs6874766 chr5:93213807 C/G cg25358565 chr5:93447407 FAM172A -1.11 -10.19 -0.53 8.9e-21 Diabetic retinopathy; CESC cis rs9733 0.744 rs12125650 chr1:150760174 A/G cg13175981 chr1:150552382 MCL1 0.52 7.24 0.41 4.84e-12 Tonsillectomy; CESC cis rs7772486 0.686 rs1292337 chr6:145967807 A/G cg23711669 chr6:146136114 FBXO30 -0.88 -13.04 -0.63 2.31e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs34779708 0.897 rs12830 chr10:35302705 C/T cg04310649 chr10:35416472 CREM -0.5 -5.99 -0.35 6.73e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs11098499 0.954 rs6838814 chr4:120392443 G/A cg24375607 chr4:120327624 NA 0.45 5.59 0.32 5.56e-8 Corneal astigmatism; CESC cis rs2243480 1.000 rs4718270 chr7:65202407 A/G cg18252515 chr7:66147081 NA -1.21 -11.36 -0.57 1.22e-24 Diabetic kidney disease; CESC cis rs116095464 0.558 rs6866632 chr5:264429 C/G cg10591111 chr5:226296 SDHA -0.47 -5.16 -0.3 4.9e-7 Breast cancer; CESC cis rs910316 0.967 rs4899545 chr14:75568138 A/G cg11812906 chr14:75593930 NEK9 0.91 15.59 0.69 2.58e-39 Height; CESC cis rs6460942 0.915 rs62447638 chr7:12484667 G/A cg06484146 chr7:12443880 VWDE -0.76 -8.5 -0.46 1.38e-15 Coronary artery disease; CESC cis rs919433 0.889 rs787995 chr2:198216853 T/G cg20885578 chr2:198174922 NA 0.4 5.42 0.32 1.31e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs78456975 1.000 rs72778004 chr2:1571892 T/A cg26248373 chr2:1572462 NA -0.55 -5.23 -0.31 3.51e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs6831352 0.703 rs3133152 chr4:100031721 C/G cg12011299 chr4:100065546 ADH4 0.57 6.88 0.39 4.34e-11 Alcohol dependence; CESC cis rs17376456 1.000 rs13181660 chr5:93533658 A/G cg25358565 chr5:93447407 FAM172A 1.13 11.09 0.56 9.68e-24 Diabetic retinopathy; CESC trans rs208520 0.955 rs12202599 chr6:67001573 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 8.7 0.47 3.56e-16 Exhaled nitric oxide output; CESC cis rs72945132 0.709 rs28634008 chr11:70225719 A/C cg00319359 chr11:70116639 PPFIA1 0.71 6.52 0.37 3.46e-10 Coronary artery disease; CESC cis rs1348850 0.598 rs12616259 chr2:178503803 C/T cg23306229 chr2:178417860 TTC30B 0.58 7.32 0.41 3.02e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6831352 1.000 rs1126671 chr4:100048414 T/C cg13256891 chr4:100009986 ADH5 0.72 8.45 0.46 1.94e-15 Alcohol dependence; CESC cis rs28498503 1.000 rs7243231 chr18:76658728 C/T cg00806245 chr18:76673096 NA -0.7 -5.6 -0.33 5.46e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs2050392 1.000 rs2250714 chr10:30697396 G/C cg18806716 chr10:30721971 MAP3K8 -0.42 -6.16 -0.35 2.62e-9 Inflammatory bowel disease; CESC cis rs1005277 0.522 rs7090858 chr10:38003670 A/C cg25427524 chr10:38739819 LOC399744 0.65 9.46 0.5 1.72e-18 Extrinsic epigenetic age acceleration; CESC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg21017887 chr14:105400489 NA -0.43 -7.07 -0.4 1.36e-11 Rheumatoid arthritis; CESC cis rs13082711 0.554 rs73055750 chr3:27401505 C/G cg02860705 chr3:27208620 NA 0.74 8.35 0.46 3.88e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg17372223 chr3:52568218 NT5DC2 -0.37 -5.15 -0.3 5.2e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC trans rs11165623 0.792 rs1931180 chr1:96914049 C/T cg10631902 chr5:14652156 NA -0.57 -8.53 -0.46 1.11e-15 Hip circumference;Waist circumference; CESC cis rs11690935 0.550 rs55653103 chr2:172861816 T/C cg13550731 chr2:172543902 DYNC1I2 0.5 6.87 0.39 4.62e-11 Schizophrenia; CESC trans rs208520 0.909 rs62414639 chr6:67023706 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.81 7.66 0.43 3.51e-13 Exhaled nitric oxide output; CESC cis rs1707322 1.000 rs4539075 chr1:46358010 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9910055 0.529 rs228748 chr17:42174390 G/A cg19774624 chr17:42201019 HDAC5 0.64 8.85 0.48 1.3e-16 Total body bone mineral density; CESC cis rs17125944 0.686 rs7160582 chr14:53341445 G/T cg00686598 chr14:53173677 PSMC6 0.93 7.23 0.41 5.1e-12 Alzheimer's disease (late onset); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg09859272 chr12:118454420 RFC5 0.57 6.27 0.36 1.47e-9 Psoriatic arthritis; CESC cis rs73206853 0.764 rs28569834 chr12:110826208 T/G cg12870014 chr12:110450643 ANKRD13A 0.61 5.62 0.33 4.8e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs561341 0.941 rs112569713 chr17:30271738 C/T cg00745463 chr17:30367425 LRRC37B -0.7 -7.1 -0.4 1.18e-11 Hip circumference adjusted for BMI; CESC cis rs2243480 0.803 rs55700941 chr7:65389800 T/A cg13147721 chr7:65941812 NA -0.88 -8.07 -0.44 2.5e-14 Diabetic kidney disease; CESC cis rs6460942 0.597 rs6977059 chr7:12535157 T/G cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs4253772 0.591 rs6008538 chr22:46685963 G/A cg18190219 chr22:46762943 CELSR1 -0.43 -5.3 -0.31 2.5e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7208859 0.623 rs8075163 chr17:29106310 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg12463550 chr7:65579703 CRCP -0.5 -6.32 -0.36 1.1e-9 Aortic root size; CESC cis rs9291683 0.588 rs6844329 chr4:10018544 T/C cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.73e-37 Bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06051243 chr13:28024682 MTIF3 -0.49 -6.86 -0.39 4.9e-11 Gut microbiota (bacterial taxa); CESC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg24531977 chr5:56204891 C5orf35 -0.51 -6.17 -0.35 2.51e-9 Coronary artery disease; CESC cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs881375 0.678 rs1014530 chr9:123685092 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.45 6.52 0.37 3.48e-10 Rheumatoid arthritis; CESC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg06873352 chr17:61820015 STRADA 0.73 12.99 0.62 3.49e-30 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16416718 chr1:6844519 CAMTA1 0.64 7.55 0.42 7.05e-13 Gut microbiome composition (summer); CESC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg14664628 chr15:75095509 CSK -0.53 -6.69 -0.38 1.29e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs7267979 0.932 rs1541061 chr20:25521057 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.76 13.66 0.64 1.58e-32 Liver enzyme levels (alkaline phosphatase); CESC cis rs3820068 0.603 rs6429768 chr1:15963531 G/A cg17385448 chr1:15911702 AGMAT 0.42 6.89 0.39 4.06e-11 Systolic blood pressure; CESC cis rs9467711 0.606 rs28362606 chr6:26365586 T/C cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.63e-7 Autism spectrum disorder or schizophrenia; CESC trans rs17685 0.753 rs12531559 chr7:75631697 C/T cg19862616 chr7:65841803 NCRNA00174 -0.81 -11.93 -0.59 1.56e-26 Coffee consumption;Coffee consumption (cups per day); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04590956 chr2:70057467 GMCL1 -0.47 -6.22 -0.36 1.93e-9 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15213732 chr10:860677 LARP4B 0.5 6.75 0.38 9.52e-11 Fibrinogen levels; CESC cis rs2836974 0.897 rs2776308 chr21:40715175 A/G cg11644478 chr21:40555479 PSMG1 0.93 13.54 0.64 4.15e-32 Cognitive function; CESC cis rs9359856 0.564 rs72913975 chr6:90387116 C/T cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.38 -0.36 7.94e-10 Bipolar disorder; CESC cis rs11997175 0.569 rs36034014 chr8:33814219 G/A ch.8.33884649F chr8:33765107 NA -0.49 -5.84 -0.34 1.5e-8 Body mass index; CESC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.52 0.37 3.48e-10 Bipolar disorder; CESC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg21984481 chr17:79567631 NPLOC4 -0.49 -8.04 -0.44 2.97e-14 Eye color traits; CESC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg05368731 chr17:41323189 NBR1 0.77 10.49 0.54 9.35e-22 Menopause (age at onset); CESC cis rs1401999 0.650 rs3749445 chr3:183638506 C/T cg01324343 chr3:183735012 ABCC5 0.46 8.93 0.48 7.18e-17 Anterior chamber depth; CESC cis rs9640161 0.789 rs3735174 chr7:150020489 T/C cg10018233 chr7:150070692 REPIN1 0.48 7.66 0.43 3.42e-13 Blood protein levels;Circulating chemerin levels; CESC cis rs1983891 0.954 rs4714481 chr6:41521110 T/C cg20194872 chr6:41519635 FOXP4 0.57 8.19 0.45 1.12e-14 Prostate cancer; CESC cis rs7520050 0.933 rs4504835 chr1:46455571 G/A cg24296786 chr1:45957014 TESK2 0.44 5.5 0.32 8.88e-8 Red blood cell count;Reticulocyte count; CESC cis rs17826219 0.500 rs57005940 chr17:29066329 C/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Body mass index; CESC cis rs1538970 0.962 rs9429077 chr1:45820667 C/A cg05343316 chr1:45956843 TESK2 0.82 11.17 0.57 5.6e-24 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13305883 chr1:145438423 TXNIP 0.54 6.01 0.35 5.96e-9 Gut microbiome composition (summer); CESC cis rs2658782 0.789 rs3020073 chr11:93103830 T/C cg15737290 chr11:93063684 CCDC67 0.57 7.26 0.41 4.36e-12 Pulmonary function decline; CESC cis rs6062302 0.522 rs2282157 chr20:62227180 C/G cg09650180 chr20:62225654 GMEB2 -0.81 -9.13 -0.49 1.76e-17 Glioblastoma; CESC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg11494091 chr17:61959527 GH2 0.72 12.22 0.6 1.56e-27 Prudent dietary pattern; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24830314 chr6:83775579 UBE2CBP 0.43 6.03 0.35 5.6e-9 Gut microbiota (bacterial taxa); CESC cis rs7223966 1.000 rs8067064 chr17:61825984 A/C cg11494091 chr17:61959527 GH2 0.39 5.25 0.31 3.18e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 6.0 0.35 6.63e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9457247 1.000 rs389956 chr6:167407254 T/G cg23791538 chr6:167370224 RNASET2 -0.59 -8.54 -0.46 1.09e-15 Crohn's disease; CESC cis rs477692 0.625 rs4751104 chr10:131405358 G/A cg05714579 chr10:131428358 MGMT -0.67 -9.69 -0.51 3.27e-19 Response to temozolomide; CESC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg07701084 chr6:150067640 NUP43 0.44 5.95 0.34 8.4e-9 Lung cancer; CESC cis rs9916302 0.861 rs11658219 chr17:37709782 G/A cg15445000 chr17:37608096 MED1 0.4 6.45 0.37 5.32e-10 Glomerular filtration rate (creatinine); CESC cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg12193833 chr17:30244370 NA -0.76 -6.94 -0.39 2.92e-11 Hip circumference adjusted for BMI; CESC cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg15556689 chr8:8085844 FLJ10661 0.51 6.28 0.36 1.36e-9 Mood instability; CESC cis rs3740713 1.000 rs113497813 chr11:18453674 A/G cg23797887 chr11:18477753 LDHAL6A -0.53 -5.11 -0.3 6.1e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs887829 0.588 rs4663971 chr2:234674252 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.53 -6.9 -0.39 3.79e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs4654899 0.628 rs11589969 chr1:21505464 A/T cg05370193 chr1:21551575 ECE1 0.36 5.48 0.32 9.65e-8 Superior frontal gyrus grey matter volume; CESC cis rs2404602 0.692 rs12902452 chr15:76921465 T/C cg22467129 chr15:76604101 ETFA -0.36 -5.32 -0.31 2.25e-7 Blood metabolite levels; CESC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg02569458 chr12:86230093 RASSF9 0.45 6.77 0.38 8.29e-11 Major depressive disorder; CESC cis rs1008375 0.966 rs3775925 chr4:17588437 A/G cg27347728 chr4:17578864 LAP3 0.46 5.56 0.32 6.52e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs938554 0.694 rs4697700 chr4:9945792 C/G cg00071950 chr4:10020882 SLC2A9 0.53 6.22 0.36 1.92e-9 Blood metabolite levels; CESC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg22800045 chr5:56110881 MAP3K1 0.83 9.99 0.52 3.69e-20 Initial pursuit acceleration; CESC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.65 0.38 1.71e-10 Prudent dietary pattern; CESC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg03188948 chr7:1209495 NA 0.73 7.02 0.4 1.85e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6429082 0.783 rs390539 chr1:235679690 A/C cg26050004 chr1:235667680 B3GALNT2 0.61 7.67 0.43 3.28e-13 Adiposity; CESC cis rs1065852 0.503 rs9620006 chr22:42399547 T/A cg22189786 chr22:42395067 WBP2NL 0.43 5.37 0.31 1.72e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs1371867 0.846 rs1788191 chr8:101260844 C/T cg11906718 chr8:101322791 RNF19A -0.48 -6.24 -0.36 1.75e-9 Atrioventricular conduction; CESC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg06456125 chr7:65229604 NA 0.41 5.22 0.31 3.7e-7 Calcium levels; CESC cis rs7071206 0.947 rs716255 chr10:79419679 A/T cg00983440 chr10:79422392 NA -0.67 -8.15 -0.45 1.5e-14 Bone mineral density; CESC cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.51e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7824557 0.527 rs2572449 chr8:11239137 A/G cg21775007 chr8:11205619 TDH 0.5 7.68 0.43 3.04e-13 Retinal vascular caliber; CESC cis rs76878669 0.561 rs10750784 chr11:66110666 A/G cg18002602 chr11:66138449 SLC29A2 -0.39 -6.42 -0.37 6.29e-10 Educational attainment (years of education); CESC cis rs8018808 0.935 rs8018711 chr14:77921749 G/A cg20045696 chr14:77926864 AHSA1 0.43 5.98 0.34 7.38e-9 Myeloid white cell count; CESC cis rs11098499 0.954 rs12510138 chr4:120423935 C/G cg24375607 chr4:120327624 NA 0.43 5.36 0.31 1.85e-7 Corneal astigmatism; CESC cis rs7949030 0.588 rs2512563 chr11:62311249 C/G cg11742103 chr11:62369870 EML3;MTA2 0.57 8.63 0.47 5.87e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19558049 chr19:306297 MIER2 0.49 6.5 0.37 4.03e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19998654 chr2:37458983 CEBPZ;C2orf56 0.63 7.72 0.43 2.4e-13 Gut microbiome composition (summer); CESC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg23172400 chr8:95962367 TP53INP1 -0.46 -9.62 -0.51 5.59e-19 Type 2 diabetes; CESC cis rs763014 0.838 rs4984670 chr16:641044 A/G cg00802000 chr16:706648 WDR90 -0.37 -5.29 -0.31 2.55e-7 Height; CESC cis rs2985684 0.841 rs7158577 chr14:50058633 C/T cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.44 -5.32 -0.31 2.17e-7 Carotid intima media thickness; CESC cis rs7267979 1.000 rs401166 chr20:25446308 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.57 0.73 2.33e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs2243480 1.000 rs73142121 chr7:65311206 C/T cg13147721 chr7:65941812 NA -0.87 -8.7 -0.47 3.54e-16 Diabetic kidney disease; CESC cis rs9443189 0.813 rs2842561 chr6:76434273 A/C cg01950844 chr6:76311363 SENP6 -0.63 -7.0 -0.39 2.13e-11 Prostate cancer; CESC cis rs834811 0.829 rs834818 chr7:135895070 A/G cg01726295 chr7:135938950 NA 0.37 6.27 0.36 1.42e-9 Post-traumatic stress disorder; CESC cis rs708547 0.697 rs67479587 chr4:57878884 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -5.58 -0.32 6.06e-8 Response to bleomycin (chromatid breaks); CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22859714 chr11:64678510 ATG2A -0.43 -6.28 -0.36 1.35e-9 Intelligence (multi-trait analysis); CESC cis rs4727027 1.000 rs4727027 chr7:148869277 C/T cg23158103 chr7:148848205 ZNF398 -0.41 -6.68 -0.38 1.44e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.47 -6.16 -0.35 2.69e-9 Platelet count; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg03252340 chr4:83293766 HNRNPD 0.42 6.11 0.35 3.59e-9 Positive affect; CESC cis rs9611565 0.512 rs5758439 chr22:42131762 C/T cg06481639 chr22:41940642 POLR3H 0.59 5.84 0.34 1.51e-8 Vitiligo; CESC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg17372223 chr3:52568218 NT5DC2 0.42 6.35 0.36 9.14e-10 Electroencephalogram traits; CESC cis rs17125944 0.686 rs7144029 chr14:53333616 G/T cg00686598 chr14:53173677 PSMC6 -0.74 -6.27 -0.36 1.48e-9 Alzheimer's disease (late onset); CESC cis rs1008375 1.000 rs1860597 chr4:17657650 C/T cg02297831 chr4:17616191 MED28 0.53 6.75 0.38 9.49e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs4662834 0.933 rs11684311 chr2:129483795 T/C cg12497543 chr10:97515377 ENTPD1 0.38 6.32 0.36 1.1e-9 Response to bleomycin (chromatid breaks); CESC cis rs9487051 0.676 rs6568566 chr6:109596792 G/A cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC cis rs9837602 1.000 rs9873878 chr3:99711816 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 7.24 0.41 4.82e-12 Breast cancer; CESC trans rs4471313 0.956 rs3119837 chr1:170352113 C/T cg14876685 chr7:99177937 NA -0.4 -6.11 -0.35 3.53e-9 Waist-hip ratio; CESC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.56 0.64 3.66e-32 Prudent dietary pattern; CESC cis rs17021463 0.673 rs1426566 chr4:95292086 T/G cg11021082 chr4:95130006 SMARCAD1 0.5 6.74 0.38 9.77e-11 Testicular germ cell tumor; CESC cis rs3540 0.574 rs2657947 chr15:90968977 C/T cg22089800 chr15:90895588 ZNF774 -0.6 -7.92 -0.44 6.77e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs3942852 0.712 rs2174129 chr11:48108557 A/C cg03929089 chr4:120376271 NA -0.62 -7.14 -0.4 9.13e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg02569458 chr12:86230093 RASSF9 0.48 7.44 0.42 1.4e-12 Major depressive disorder; CESC cis rs8016982 0.674 rs6574631 chr14:81675772 C/T cg01989461 chr14:81687754 GTF2A1 0.75 11.74 0.59 6.44e-26 Schizophrenia; CESC cis rs4835473 0.932 rs11100824 chr4:144885998 C/T cg25736465 chr4:144833511 NA 0.41 6.25 0.36 1.64e-9 Immature fraction of reticulocytes; CESC cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.19 0.3 4.29e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs637571 0.522 rs542332 chr11:65744421 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 10.63 0.55 3.17e-22 Eosinophil percentage of white cells; CESC cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.45 5.46 0.32 1.11e-7 Tonsillectomy; CESC cis rs763121 0.853 rs5757208 chr22:39049230 A/C cg06022373 chr22:39101656 GTPBP1 0.88 13.91 0.65 2.06e-33 Menopause (age at onset); CESC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg27170947 chr2:26402098 FAM59B -0.84 -10.04 -0.52 2.68e-20 Gut microbiome composition (summer); CESC cis rs637571 0.676 rs1151523 chr11:65665200 C/T cg26695010 chr11:65641043 EFEMP2 0.5 6.43 0.37 5.84e-10 Eosinophil percentage of white cells; CESC cis rs4820539 0.966 rs5759594 chr22:23470660 G/A cg14186256 chr22:23484241 RTDR1 0.83 15.0 0.68 3.12e-37 Bone mineral density; CESC cis rs6987853 0.814 rs2923411 chr8:42455206 T/C cg09913449 chr8:42400586 C8orf40 0.42 7.02 0.4 1.88e-11 Mean corpuscular hemoglobin concentration; CESC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg03452623 chr4:187889614 NA -0.88 -16.16 -0.7 2.39e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg01579765 chr21:45077557 HSF2BP -0.52 -8.59 -0.47 7.47e-16 Mean corpuscular volume; CESC trans rs2727020 0.894 rs1917328 chr11:49359606 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -9.43 -0.5 2.16e-18 Coronary artery disease; CESC cis rs34172651 0.606 rs7194189 chr16:24703484 G/T cg06505273 chr16:24850292 NA -0.45 -5.62 -0.33 4.89e-8 Intelligence (multi-trait analysis); CESC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg08736216 chr1:53307985 ZYG11A 0.36 6.32 0.36 1.09e-9 Monocyte count; CESC cis rs11785400 1.000 rs3824208 chr8:143743653 C/G cg24634471 chr8:143751801 JRK 0.47 6.21 0.36 2e-9 Schizophrenia; CESC cis rs1023500 0.552 rs133368 chr22:42463689 T/C cg15557168 chr22:42548783 NA -0.47 -6.81 -0.39 6.59e-11 Schizophrenia; CESC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.91e-10 Bipolar disorder; CESC cis rs17253792 0.822 rs74968702 chr14:56076818 A/T cg01858014 chr14:56050164 KTN1 -0.83 -7.03 -0.4 1.7e-11 Putamen volume; CESC cis rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03009463 chr7:17980271 SNX13 -0.42 -5.36 -0.31 1.79e-7 Fibrinogen levels; CESC cis rs1062177 1.000 rs2347596 chr5:151179199 T/C cg12924095 chr5:151150029 G3BP1 0.49 6.44 0.37 5.67e-10 Preschool internalizing problems; CESC cis rs1035144 0.785 rs12323356 chr14:81464279 A/G cg06600135 chr14:81408086 NA 0.4 5.33 0.31 2.14e-7 Male sexual orientation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11279933 chr10:71211301 TSPAN15 0.58 6.41 0.37 6.82e-10 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09706721 chr3:196664468 NCBP2 -0.49 -6.64 -0.38 1.74e-10 Systemic lupus erythematosus; CESC cis rs13242816 1.000 rs56309428 chr7:116150137 G/T cg04696780 chr7:116139425 CAV2 -0.61 -5.55 -0.32 7.01e-8 P wave duration; CESC cis rs17818399 0.547 rs12997164 chr2:46758746 A/C cg02822958 chr2:46747628 ATP6V1E2 0.42 5.2 0.3 4.08e-7 Height; CESC trans rs7120489 0.748 rs57628814 chr11:12456399 G/A cg20690916 chr5:140700301 TAF7 -0.95 -6.34 -0.36 9.6e-10 Mortality in heart failure; CESC cis rs2074585 0.560 rs1973537 chr15:91062901 T/C cg10434728 chr15:90938212 IQGAP1 -0.31 -5.08 -0.3 7.28e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs7826238 0.535 rs2979179 chr8:8320029 C/T cg15556689 chr8:8085844 FLJ10661 0.6 8.25 0.45 7.27e-15 Systolic blood pressure; CESC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg26338869 chr17:61819248 STRADA 0.71 9.47 0.5 1.6e-18 Prudent dietary pattern; CESC cis rs738322 0.935 rs4384 chr22:38572440 G/C cg25457927 chr22:38595422 NA -0.31 -5.77 -0.33 2.17e-8 Cutaneous nevi; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17655527 chr19:56128027 NA 0.53 6.95 0.39 2.8e-11 Fibrinogen levels; CESC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg17971929 chr21:40555470 PSMG1 1.04 15.61 0.69 2.11e-39 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11450001 chr12:10365596 GABARAPL1 0.58 6.52 0.37 3.5e-10 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs1612419 chr1:46546945 T/C cg06784218 chr1:46089804 CCDC17 -0.35 -5.86 -0.34 1.36e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17237320 chr3:10053000 LOC401052 0.57 6.06 0.35 4.66e-9 Gut microbiome composition (summer); CESC cis rs1878931 0.543 rs17612463 chr16:3420479 G/C cg02880119 chr16:3481970 NA -0.4 -5.22 -0.31 3.67e-7 Body mass index (adult); CESC cis rs7607369 0.559 rs13027908 chr2:219660374 T/C cg02176678 chr2:219576539 TTLL4 -0.4 -7.1 -0.4 1.18e-11 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg09323728 chr8:95962352 TP53INP1 -0.39 -8.53 -0.46 1.11e-15 Type 2 diabetes; CESC trans rs2823962 0.697 rs9984100 chr21:18016486 C/A cg06419850 chr17:4688683 VMO1 -0.43 -6.17 -0.35 2.48e-9 Amyotrophic lateral sclerosis; CESC cis rs920590 0.758 rs35896770 chr8:19665616 G/C cg17834443 chr8:19674713 INTS10 0.6 6.79 0.38 7.33e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs9815354 0.680 rs79211428 chr3:41921810 C/T cg03022575 chr3:42003672 ULK4 0.59 5.49 0.32 9.55e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs30380 0.632 rs26498 chr5:96138812 C/T cg16492584 chr5:96139282 ERAP1 0.48 6.71 0.38 1.17e-10 Cerebrospinal fluid biomarker levels; CESC cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg17143192 chr8:8559678 CLDN23 0.78 8.81 0.48 1.65e-16 Obesity-related traits; CESC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg19901468 chr14:105411992 AHNAK2 -0.57 -8.26 -0.45 6.94e-15 Rheumatoid arthritis; CESC cis rs72945132 0.882 rs67927691 chr11:70128786 C/A cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC trans rs7618501 0.633 rs6446193 chr3:50059758 T/C cg21659725 chr3:3221576 CRBN -0.48 -6.74 -0.38 9.75e-11 Intelligence (multi-trait analysis); CESC cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg00255919 chr5:131827918 IRF1 -0.58 -9.99 -0.52 3.86e-20 Asthma (sex interaction); CESC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg22143856 chr6:28129313 ZNF389 0.53 6.71 0.38 1.2e-10 Depression; CESC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg07157834 chr1:205819609 PM20D1 0.72 10.78 0.55 1.06e-22 Menarche (age at onset); CESC cis rs9291683 0.655 rs3822242 chr4:10094904 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.21 -0.49 9.99e-18 Bone mineral density; CESC trans rs1814175 0.645 rs7952104 chr11:49964180 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs9488822 0.636 rs12524932 chr6:116330266 G/A cg18764771 chr6:116381957 FRK 0.22 5.37 0.31 1.68e-7 Cholesterol, total;LDL cholesterol; CESC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.21 -0.36 2.01e-9 Schizophrenia; CESC cis rs1707322 1.000 rs12060274 chr1:46291062 G/T cg06784218 chr1:46089804 CCDC17 0.32 5.47 0.32 1.04e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1729951 0.575 rs361242 chr3:136698330 C/G cg03617693 chr3:136751559 NA 0.39 5.53 0.32 7.62e-8 Neuroticism; CESC cis rs2832191 0.511 rs7278227 chr21:30482707 C/T cg24692254 chr21:30365293 RNF160 -0.59 -8.05 -0.44 2.84e-14 Dental caries; CESC cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg05340658 chr4:99064831 C4orf37 0.76 11.18 0.57 4.88e-24 Colonoscopy-negative controls vs population controls; CESC cis rs614226 0.516 rs1794748 chr12:120953758 A/G cg01236616 chr12:121019343 POP5 1.55 19.98 0.78 8.29e-55 Type 1 diabetes nephropathy; CESC cis rs2268241 0.938 rs9978223 chr21:34770358 G/A cg14850771 chr21:34775459 IFNGR2 0.93 11.49 0.58 4.73e-25 Obesity-related traits; CESC cis rs807669 0.868 rs762529 chr22:19170205 C/G cg02655711 chr22:19163373 SLC25A1 0.95 14.43 0.66 3.1e-35 Metabolite levels; CESC cis rs9303401 0.659 rs12948133 chr17:56673602 T/C cg10487724 chr17:56770010 TEX14;RAD51C 1.04 12.83 0.62 1.23e-29 Cognitive test performance; CESC cis rs3820068 0.581 rs6693694 chr1:15980135 G/T cg16988262 chr1:15930761 NA 0.33 5.4 0.31 1.47e-7 Systolic blood pressure; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06963844 chr1:11724238 FBXO6 0.46 6.31 0.36 1.17e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1775715 0.811 rs1775741 chr10:32267284 C/T cg18675610 chr10:32216311 ARHGAP12 -0.33 -5.04 -0.3 8.46e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4704187 0.687 rs13359143 chr5:74433360 T/C cg03227963 chr5:74354835 NA 0.3 5.55 0.32 6.82e-8 Response to amphetamines; CESC trans rs1908814 0.516 rs13252853 chr8:11792974 T/C cg15556689 chr8:8085844 FLJ10661 0.54 6.58 0.37 2.47e-10 Neuroticism; CESC trans rs11148252 0.553 rs2147692 chr13:53287023 C/G cg18335740 chr13:41363409 SLC25A15 0.54 7.29 0.41 3.56e-12 Lewy body disease; CESC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg04287289 chr16:89883240 FANCA 0.88 15.13 0.68 1.09e-37 Vitiligo; CESC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg22638593 chr5:131593259 PDLIM4 0.39 5.04 0.3 8.45e-7 Acylcarnitine levels; CESC trans rs7246657 0.943 rs3760825 chr19:37945601 C/T cg01833234 chr11:6592585 DNHD1 0.52 6.0 0.35 6.5e-9 Coronary artery calcification; CESC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg24531977 chr5:56204891 C5orf35 0.69 9.38 0.5 3.14e-18 Initial pursuit acceleration; CESC cis rs9487051 0.837 rs2356817 chr6:109642675 G/A cg01475377 chr6:109611718 NA -0.51 -8.18 -0.45 1.19e-14 Reticulocyte fraction of red cells; CESC cis rs2439831 0.571 rs2470121 chr15:43937618 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.81 8.46 0.46 1.81e-15 Lung cancer in ever smokers; CESC cis rs3820928 0.874 rs10933165 chr2:227883648 C/G cg11843606 chr2:227700838 RHBDD1 0.45 5.79 0.34 1.95e-8 Pulmonary function; CESC cis rs523522 0.923 rs2235217 chr12:120884328 C/T cg27279351 chr12:120934652 DYNLL1 0.67 8.43 0.46 2.18e-15 High light scatter reticulocyte count; CESC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.57 0.54 4.93e-22 Height; CESC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg06877462 chr1:205807181 PM20D1 0.39 5.84 0.34 1.51e-8 Menarche (age at onset); CESC cis rs6963495 0.556 rs818481 chr7:105158467 G/C cg19920283 chr7:105172520 RINT1 0.54 6.28 0.36 1.35e-9 Bipolar disorder (body mass index interaction); CESC cis rs7666738 0.830 rs35560671 chr4:99069095 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.5 0.46 1.41e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7617480 0.648 rs4858800 chr3:48755820 A/G cg07636037 chr3:49044803 WDR6 0.78 10.07 0.53 2.11e-20 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs79387448 0.701 rs11465586 chr2:102982709 C/G cg09003973 chr2:102972529 NA 1.21 9.49 0.5 1.45e-18 Gut microbiota (bacterial taxa); CESC cis rs3806843 1.000 rs7710794 chr5:140209467 T/G cg26395211 chr5:140044315 WDR55 -0.41 -5.05 -0.3 8.38e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg18512352 chr11:47633146 NA -0.57 -7.96 -0.44 5.22e-14 Subjective well-being; CESC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg03647317 chr4:187891568 NA -0.37 -5.56 -0.32 6.44e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs12586317 1.000 rs12586317 chr14:35682172 T/C cg16230307 chr14:35515116 FAM177A1 0.77 8.09 0.45 2.16e-14 Psoriasis; CESC cis rs10465746 0.935 rs4907189 chr1:84374982 G/T cg10977910 chr1:84465055 TTLL7 0.47 6.37 0.36 8.2e-10 Obesity-related traits; CESC cis rs6723226 0.842 rs2754522 chr2:32801257 C/G cg02381751 chr2:32503542 YIPF4 0.84 12.32 0.6 7.12e-28 Intelligence (multi-trait analysis); CESC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg06505273 chr16:24850292 NA 0.53 6.51 0.37 3.7e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs854765 0.616 rs8070624 chr17:17843396 G/A cg09796270 chr17:17721594 SREBF1 0.45 6.05 0.35 4.93e-9 Total body bone mineral density; CESC cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs11645898 0.688 rs398580 chr16:72095453 A/G cg14768367 chr16:72042858 DHODH -0.79 -6.25 -0.36 1.65e-9 Blood protein levels; CESC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg03452623 chr4:187889614 NA -0.67 -10.86 -0.55 5.81e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg18180107 chr4:99064573 C4orf37 0.4 5.05 0.3 8.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs711830 1.000 rs1051929 chr2:177036754 T/C cg13092806 chr2:177043255 NA 0.87 11.84 0.59 3.15e-26 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CESC cis rs10857712 0.904 rs2265641 chr10:135221869 G/A cg01444801 chr10:135216882 MTG1 0.47 5.66 0.33 3.99e-8 Systemic lupus erythematosus; CESC cis rs10465746 0.714 rs12141272 chr1:84434517 C/T cg10977910 chr1:84465055 TTLL7 0.52 7.06 0.4 1.44e-11 Obesity-related traits; CESC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg18099408 chr3:52552593 STAB1 -0.31 -5.19 -0.3 4.27e-7 Bipolar disorder; CESC cis rs9818758 0.607 rs35673421 chr3:49139406 G/A cg00383909 chr3:49044727 WDR6 0.89 6.57 0.37 2.68e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg24110177 chr3:50126178 RBM5 -0.51 -7.09 -0.4 1.21e-11 Intelligence (multi-trait analysis); CESC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg03538708 chr1:25844672 NA -0.37 -5.72 -0.33 2.91e-8 Erythrocyte sedimentation rate; CESC cis rs751728 1.000 rs3806108 chr6:33767579 C/G cg25922239 chr6:33757077 LEMD2 0.56 7.77 0.43 1.75e-13 Crohn's disease; CESC cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg00999950 chr4:99064541 C4orf37 0.46 6.81 0.39 6.7e-11 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.81 0.59 3.88e-26 Alzheimer's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06836181 chr2:64995545 NA -0.45 -6.53 -0.37 3.37e-10 Gambling; CESC cis rs9815354 0.812 rs35263917 chr3:41952852 T/C cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.9e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9300255 0.537 rs1716182 chr12:123686127 A/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.4 -0.37 6.92e-10 Neutrophil percentage of white cells; CESC cis rs16854884 0.710 rs9829796 chr3:143801416 C/T cg06585982 chr3:143692056 C3orf58 0.45 5.82 0.34 1.66e-8 Economic and political preferences (feminism/equality); CESC cis rs9581857 0.685 rs9319373 chr13:28042835 A/G cg22138327 chr13:27999177 GTF3A 0.62 5.22 0.31 3.69e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg04267008 chr7:1944627 MAD1L1 -0.7 -8.87 -0.48 1.12e-16 Bipolar disorder and schizophrenia; CESC cis rs796364 0.806 rs74266489 chr2:201005732 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -6.83 -0.39 5.71e-11 Schizophrenia; CESC cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg22875332 chr1:76189707 ACADM 0.58 5.73 0.33 2.66e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs791888 0.858 rs1555434 chr10:89419143 G/C cg13926569 chr10:89418898 PAPSS2 -0.53 -7.62 -0.42 4.58e-13 Magnesium levels; CESC cis rs4843747 0.636 rs11117358 chr16:88105053 T/A cg06374794 chr16:88002281 BANP 0.39 5.14 0.3 5.47e-7 Menopause (age at onset); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg20975532 chr1:184939506 FAM129A 0.37 6.02 0.35 5.78e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs17039065 1.000 rs4449483 chr4:109401379 C/A cg16022748 chr4:109541635 LOC285456;RPL34 0.67 5.63 0.33 4.68e-8 Gut microbiome composition (summer); CESC cis rs3796352 1.000 rs6445557 chr3:53083969 C/T cg07884673 chr3:53033167 SFMBT1 -0.57 -5.62 -0.33 4.74e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs9660992 0.674 rs1151784 chr1:205232447 C/T cg21643547 chr1:205240462 TMCC2 -0.47 -6.34 -0.36 1.01e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs7726839 0.794 rs10053310 chr5:595661 C/G cg09021430 chr5:549028 NA -0.44 -6.17 -0.35 2.54e-9 Obesity-related traits; CESC cis rs7769051 0.522 rs73554461 chr6:133139087 T/G cg07930552 chr6:133119739 C6orf192 0.94 6.82 0.39 6.26e-11 Type 2 diabetes nephropathy; CESC cis rs9314323 0.729 rs7007256 chr8:26203081 G/A cg11498726 chr8:26250323 BNIP3L -0.5 -6.98 -0.39 2.39e-11 Red cell distribution width; CESC cis rs6545883 0.931 rs11125885 chr2:61755728 G/C cg15711740 chr2:61764176 XPO1 -0.44 -5.37 -0.31 1.73e-7 Tuberculosis; CESC cis rs1881797 1.000 rs12071797 chr1:247686871 A/G cg21399703 chr1:247681439 NA 0.55 7.37 0.41 2.13e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.688 rs4632667 chr4:98748299 A/G cg17366294 chr4:99064904 C4orf37 0.56 5.96 0.34 8.11e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2273669 0.667 rs12206423 chr6:109353216 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.33 -0.36 1.04e-9 Prostate cancer; CESC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg07701084 chr6:150067640 NUP43 0.49 6.78 0.38 7.65e-11 Lung cancer; CESC cis rs611744 0.647 rs2298603 chr8:109271426 C/T cg21045802 chr8:109455806 TTC35 0.51 6.59 0.38 2.39e-10 Dupuytren's disease; CESC cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg19077165 chr18:44547161 KATNAL2 0.52 7.41 0.41 1.74e-12 Personality dimensions; CESC cis rs861020 0.604 rs3766612 chr1:210020013 G/T cg05527609 chr1:210001259 C1orf107 -0.98 -12.67 -0.61 4.28e-29 Orofacial clefts; CESC cis rs202629 1 rs202629 chr22:41849975 C/T cg03806693 chr22:41940476 POLR3H 1.14 15.52 0.69 4.45e-39 Cannabis dependence symptom count; CESC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg17372223 chr3:52568218 NT5DC2 0.44 6.57 0.37 2.59e-10 Bipolar disorder; CESC cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg04166393 chr7:2884313 GNA12 0.41 5.31 0.31 2.32e-7 Height; CESC cis rs8180040 0.764 rs11712716 chr3:47193432 T/C cg27129171 chr3:47204927 SETD2 0.69 10.44 0.54 1.33e-21 Colorectal cancer; CESC cis rs11650494 0.710 rs2233666 chr17:47484286 T/C cg08112188 chr17:47440006 ZNF652 1.12 7.26 0.41 4.22e-12 Prostate cancer; CESC cis rs2017305 0.834 rs12244293 chr10:70783580 A/G cg01024728 chr10:70782572 NA 0.58 5.87 0.34 1.33e-8 Depression (quantitative trait); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08887952 chr4:16257948 FLJ39653 -0.49 -6.0 -0.35 6.48e-9 Gut microbiome composition (summer); CESC cis rs3820068 0.705 rs4646031 chr1:15834648 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.91 0.34 1.03e-8 Systolic blood pressure; CESC cis rs3820928 0.904 rs4414671 chr2:227816200 T/A cg11843606 chr2:227700838 RHBDD1 -0.48 -6.38 -0.37 7.64e-10 Pulmonary function; CESC cis rs6912958 0.781 rs3757368 chr6:88224495 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.51 -6.83 -0.39 5.94e-11 Monocyte percentage of white cells; CESC cis rs2204008 0.837 rs34381557 chr12:38181983 T/C cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg05368731 chr17:41323189 NBR1 0.8 11.32 0.57 1.66e-24 Menopause (age at onset); CESC cis rs4635969 0.718 rs27068 chr5:1347239 C/T cg07493874 chr5:1342172 CLPTM1L -0.44 -6.37 -0.36 8.51e-10 Testicular germ cell tumor;Testicular germ cell cancer; CESC cis rs6495122 0.699 rs1378942 chr15:75077367 A/C cg09165964 chr15:75287851 SCAMP5 -0.4 -5.23 -0.31 3.42e-7 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs2479106 0.569 rs4838071 chr9:126366539 C/A cg16191174 chr9:126692580 DENND1A 0.38 5.3 0.31 2.4e-7 Polycystic ovary syndrome; CESC cis rs637571 0.522 rs550435 chr11:65732651 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.47 6.28 0.36 1.35e-9 Eosinophil percentage of white cells; CESC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg07092213 chr7:1199455 ZFAND2A -0.39 -5.37 -0.31 1.74e-7 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02577487 chr10:11653628 USP6NL 0.57 6.63 0.38 1.87e-10 Gut microbiome composition (summer); CESC cis rs7586879 0.639 rs2033654 chr2:25103108 C/A cg01884057 chr2:25150051 NA 0.37 7.21 0.41 5.78e-12 Body mass index; CESC cis rs2251381 0.741 rs2735966 chr21:30538174 G/A cg24692254 chr21:30365293 RNF160 0.77 10.56 0.54 5.36e-22 Selective IgA deficiency; CESC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg24879335 chr3:133465180 TF 0.31 5.15 0.3 5.03e-7 Iron status biomarkers; CESC cis rs763121 0.853 rs2072795 chr22:39064209 A/G cg06544989 chr22:39130855 UNC84B -0.49 -8.48 -0.46 1.59e-15 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14219290 chr14:34420499 EGLN3 -0.57 -6.47 -0.37 4.64e-10 Gut microbiome composition (summer); CESC cis rs7980687 0.657 rs10744151 chr12:123723735 G/C cg05973401 chr12:123451056 ABCB9 0.45 5.46 0.32 1.08e-7 Height;Educational attainment;Head circumference (infant); CESC cis rs4073582 0.595 rs474005 chr11:66033301 C/T cg14036092 chr11:66035641 RAB1B 0.56 7.87 0.44 9.14e-14 Gout; CESC cis rs1413885 0.549 rs4593866 chr1:65850968 G/C cg14976592 chr1:65886160 LEPROT;LEPR 0.47 6.16 0.35 2.64e-9 Anticoagulant levels; CESC cis rs3857067 1.000 rs1904095 chr4:95012530 G/A cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.53 -0.42 8.12e-13 QT interval; CESC cis rs1707322 1.000 rs10789486 chr1:46408667 A/G cg03146154 chr1:46216737 IPP 0.7 9.46 0.5 1.75e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs72781680 0.898 rs7563564 chr2:23993404 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs35110281 0.693 rs3819161 chr21:45092653 A/G cg21573476 chr21:45109991 RRP1B -0.58 -7.98 -0.44 4.37e-14 Mean corpuscular volume; CESC cis rs67311347 0.544 rs9814779 chr3:40340431 T/C cg09455208 chr3:40491958 NA 0.36 6.35 0.36 9.37e-10 Renal cell carcinoma; CESC cis rs3733585 0.726 rs4306953 chr4:9955776 G/A cg02734326 chr4:10020555 SLC2A9 -0.4 -5.77 -0.33 2.19e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7216064 0.531 rs62084683 chr17:66031725 A/G cg07042672 chr17:66097459 LOC651250 0.66 8.86 0.48 1.21e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11638352 1.000 rs2555385 chr15:44419459 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.59 -5.42 -0.32 1.33e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg02353165 chr6:42928485 GNMT 0.82 12.73 0.62 2.68e-29 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4566357 0.615 rs6436644 chr2:227914275 T/A cg11843606 chr2:227700838 RHBDD1 -0.48 -6.58 -0.37 2.45e-10 Coronary artery disease; CESC cis rs6580649 0.941 rs11612578 chr12:48414798 T/C cg24011408 chr12:48396354 COL2A1 -0.42 -5.18 -0.3 4.39e-7 Lung cancer; CESC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg18350739 chr11:68623251 NA -0.44 -6.49 -0.37 4.25e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6741892 0.536 rs6761563 chr2:38891406 A/T cg01546378 chr2:38892901 GALM -0.53 -7.11 -0.4 1.05e-11 5-HTT brain serotonin transporter levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00627621 chr8:126442449 TRIB1 0.41 6.26 0.36 1.58e-9 Gambling; CESC cis rs1050631 0.564 rs8098627 chr18:33721636 T/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.51e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs897984 0.762 rs4889599 chr16:30968589 C/T cg02466173 chr16:30829666 NA 0.47 7.92 0.44 6.36e-14 Dementia with Lewy bodies; CESC cis rs829883 0.902 rs829884 chr12:98879500 C/G cg25150519 chr12:98850993 NA 0.68 9.06 0.49 2.94e-17 Colorectal adenoma (advanced); CESC cis rs9847710 0.524 rs11712910 chr3:53094194 C/A cg18337363 chr3:52569053 NT5DC2 -0.32 -5.13 -0.3 5.56e-7 Ulcerative colitis; CESC cis rs7927771 0.896 rs12794570 chr11:47658314 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -5.92 -0.34 1.02e-8 Subjective well-being; CESC cis rs6598955 0.572 rs12089219 chr1:26638751 C/T cg19743891 chr1:26644573 UBXN11;CD52 0.36 5.21 0.3 3.85e-7 Obesity-related traits; CESC cis rs5753618 0.583 rs8138596 chr22:31786961 T/A cg13145458 chr22:31556086 RNF185 -0.52 -6.17 -0.35 2.6e-9 Colorectal cancer; CESC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg05872129 chr22:39784769 NA -0.83 -11.27 -0.57 2.51e-24 Intelligence (multi-trait analysis); CESC cis rs2658782 0.950 rs2446061 chr11:93149277 C/T cg15737290 chr11:93063684 CCDC67 0.52 6.34 0.36 1e-9 Pulmonary function decline; CESC cis rs11920090 0.858 rs66683764 chr3:170720960 A/G cg09710316 chr3:170744871 SLC2A2 0.47 5.38 0.31 1.62e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs7395581 0.918 rs4752824 chr11:47324666 A/T cg25783544 chr11:47291846 MADD 0.58 7.46 0.42 1.23e-12 HDL cholesterol; CESC cis rs7772486 0.686 rs7739735 chr6:146123536 G/A cg05347473 chr6:146136440 FBXO30 0.52 6.84 0.39 5.37e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs35849525 0.814 rs7635601 chr3:50044006 A/T cg24110177 chr3:50126178 RBM5 -0.45 -5.59 -0.33 5.5e-8 Intelligence (multi-trait analysis); CESC cis rs7202877 0.656 rs3851736 chr16:75387332 T/C cg04384234 chr16:75411784 CFDP1 -0.49 -5.93 -0.34 9.17e-9 Type 2 diabetes;Type 1 diabetes; CESC cis rs4481887 1.000 rs10888362 chr1:248483975 A/G cg00666640 chr1:248458726 OR2T12 -0.39 -6.44 -0.37 5.47e-10 Common traits (Other); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14361641 chr2:70056642 GMCL1 0.5 6.45 0.37 5.36e-10 Gut microbiota (bacterial taxa); CESC cis rs798766 1.000 rs1665362 chr4:1726367 T/A cg07041428 chr4:1763019 NA -0.4 -5.75 -0.33 2.45e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.42 -5.36 -0.31 1.8e-7 Tonsillectomy; CESC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg24829409 chr8:58192753 C8orf71 -0.64 -8.48 -0.46 1.61e-15 Developmental language disorder (linguistic errors); CESC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg13206674 chr6:150067644 NUP43 0.41 5.67 0.33 3.73e-8 Lung cancer; CESC cis rs12134245 0.747 rs11164929 chr1:92012836 G/C cg21854759 chr1:92012499 NA -0.47 -6.03 -0.35 5.57e-9 Breast cancer; CESC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg07677032 chr17:61819896 STRADA 0.46 6.22 0.36 1.92e-9 Prudent dietary pattern; CESC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg05313129 chr8:58192883 C8orf71 -0.51 -5.06 -0.3 7.87e-7 Developmental language disorder (linguistic errors); CESC cis rs9858542 0.953 rs9821311 chr3:49543656 C/T cg07274523 chr3:49395745 GPX1 0.66 8.05 0.44 2.82e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4835473 0.742 rs6537238 chr4:144917616 T/C cg25736465 chr4:144833511 NA 0.42 6.28 0.36 1.38e-9 Immature fraction of reticulocytes; CESC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.67 6.53 0.37 3.43e-10 LDL cholesterol;Cholesterol, total; CESC cis rs9399137 0.507 rs12663447 chr6:135317026 A/C cg22676075 chr6:135203613 NA 0.53 7.09 0.4 1.22e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7809950 0.723 rs62483633 chr7:106876644 T/G cg23024343 chr7:107201750 COG5 -0.54 -6.86 -0.39 4.97e-11 Coronary artery disease; CESC cis rs57221529 0.766 rs56278696 chr5:582669 A/G cg16447950 chr5:562315 NA -0.62 -6.48 -0.37 4.46e-10 Lung disease severity in cystic fibrosis; CESC cis rs897984 0.513 rs17839568 chr16:31099783 T/C cg00531865 chr16:30841666 NA -0.39 -5.35 -0.31 1.93e-7 Dementia with Lewy bodies; CESC cis rs7605827 0.930 rs4668927 chr2:15706683 C/T cg19274914 chr2:15703543 NA 0.36 6.43 0.37 5.91e-10 Educational attainment (years of education); CESC cis rs11098499 0.908 rs71614449 chr4:120387055 C/T cg24375607 chr4:120327624 NA 0.44 5.48 0.32 9.91e-8 Corneal astigmatism; CESC cis rs4595586 0.545 rs12816546 chr12:39398913 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.47 0.42 1.16e-12 Morning vs. evening chronotype; CESC cis rs9905704 0.633 rs917016 chr17:56454156 C/T cg12560992 chr17:57184187 TRIM37 -0.62 -5.78 -0.33 2.13e-8 Testicular germ cell tumor; CESC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg14338887 chr6:42928500 GNMT 0.37 5.32 0.31 2.17e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.25 0.53 5.71e-21 Prudent dietary pattern; CESC cis rs10870270 0.956 rs11146425 chr10:133734261 C/T cg26149184 chr10:133730230 NA 0.38 5.15 0.3 5.07e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs3204270 0.639 rs62077183 chr17:79658940 C/A cg18367735 chr17:79674897 NA 0.66 5.62 0.33 4.87e-8 Dental caries; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg15147215 chr3:52552868 STAB1 -0.33 -5.89 -0.34 1.17e-8 Hemoglobin concentration; CESC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg12667521 chr19:29218732 NA 0.48 6.4 0.37 6.97e-10 Methadone dose in opioid dependence; CESC cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg22875332 chr1:76189707 ACADM -0.6 -6.25 -0.36 1.67e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs796364 0.616 rs7574313 chr2:200681040 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.55 5.06 0.3 7.93e-7 Schizophrenia; CESC cis rs1050631 0.564 rs1625385 chr18:33717364 C/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.51e-15 Esophageal squamous cell cancer (length of survival); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24129618 chr8:22102425 POLR3D 0.63 7.51 0.42 8.97e-13 Gut microbiome composition (summer); CESC cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg03433033 chr1:76189801 ACADM 0.58 5.63 0.33 4.51e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1707322 0.752 rs61784798 chr1:46173481 C/T cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs34779708 0.966 rs35146199 chr10:35460939 T/C cg03585969 chr10:35415529 CREM 0.77 10.17 0.53 1.03e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6088580 0.634 rs2378134 chr20:32938085 C/T cg24642439 chr20:33292090 TP53INP2 -0.52 -6.73 -0.38 1.04e-10 Glomerular filtration rate (creatinine); CESC cis rs7917772 0.503 rs7087665 chr10:104282418 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.18 0.3 4.34e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg02159808 chr21:46707872 POFUT2;LOC642852 -0.7 -9.42 -0.5 2.31e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs863345 0.584 rs10797024 chr1:158497163 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.78e-11 Pneumococcal bacteremia; CESC cis rs7107174 1.000 rs2511157 chr11:77972632 G/A cg02023728 chr11:77925099 USP35 0.48 6.35 0.36 9.5e-10 Testicular germ cell tumor; CESC cis rs1577917 0.740 rs6926049 chr6:86266133 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.56 7.83 0.43 1.15e-13 Response to antipsychotic treatment; CESC cis rs9916302 0.904 rs11078910 chr17:37671269 G/T cg15445000 chr17:37608096 MED1 0.42 7.04 0.4 1.69e-11 Glomerular filtration rate (creatinine); CESC trans rs561341 1.000 rs4795669 chr17:30244701 C/T cg20587970 chr11:113659929 NA -1.11 -13.47 -0.64 7.57e-32 Hip circumference adjusted for BMI; CESC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg07308232 chr7:1071921 C7orf50 -0.5 -7.19 -0.4 6.5e-12 Longevity;Endometriosis; CESC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg12463550 chr7:65579703 CRCP -0.5 -6.32 -0.36 1.08e-9 Aortic root size; CESC cis rs4006360 0.505 rs9916287 chr17:39286884 T/G cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.42 -5.33 -0.31 2.11e-7 Bipolar disorder and schizophrenia; CESC cis rs9611565 0.573 rs9306355 chr22:42111896 A/T cg06634786 chr22:41940651 POLR3H 0.45 5.07 0.3 7.43e-7 Vitiligo; CESC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg12463550 chr7:65579703 CRCP 0.56 7.16 0.4 8.17e-12 Aortic root size; CESC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg10691866 chr7:65817282 TPST1 0.31 5.34 0.31 1.95e-7 Aortic root size; CESC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 9.43 0.5 2.11e-18 Platelet count; CESC cis rs3791556 1.000 rs2411429 chr2:240113928 A/G cg03281426 chr2:240109471 HDAC4 0.49 5.64 0.33 4.44e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6582630 0.513 rs11181246 chr12:38302670 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs9611565 0.506 rs2024567 chr22:41699206 G/C cg17376030 chr22:41985996 PMM1 0.49 5.43 0.32 1.26e-7 Vitiligo; CESC cis rs3749237 0.964 rs35210174 chr3:49812606 C/T cg03060546 chr3:49711283 APEH 0.64 7.52 0.42 8.71e-13 Resting heart rate; CESC cis rs820218 0.798 rs9912282 chr17:73673796 G/A cg01592526 chr17:73663357 RECQL5;SAP30BP -0.43 -5.88 -0.34 1.25e-8 Rotator cuff tears; CESC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg27170947 chr2:26402098 FAM59B -0.59 -7.07 -0.4 1.39e-11 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg06582575 chr6:163149167 PACRG;PARK2 0.99 10.2 0.53 8.22e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg06713675 chr4:122721982 EXOSC9 -0.51 -6.96 -0.39 2.71e-11 Type 2 diabetes; CESC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.1e-18 Prudent dietary pattern; CESC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg08470875 chr2:26401718 FAM59B -0.48 -5.35 -0.31 1.89e-7 Gut microbiome composition (summer); CESC cis rs9303401 0.659 rs34170300 chr17:56789905 G/C cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC trans rs35110281 1.000 rs35110281 chr21:45068947 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 6.85 0.39 5.04e-11 Mean corpuscular volume; CESC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg19163074 chr7:65112434 INTS4L2 0.44 5.47 0.32 1.05e-7 Aortic root size; CESC cis rs7103648 1.000 rs12292911 chr11:47449072 C/T cg20307385 chr11:47447363 PSMC3 1.01 17.71 0.74 7.61e-47 Diastolic blood pressure;Systolic blood pressure; CESC cis rs1878931 0.597 rs37816 chr16:3456371 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.77 -9.09 -0.49 2.41e-17 Body mass index (adult); CESC cis rs447735 0.507 rs11645271 chr16:89729125 G/T cg03605463 chr16:89740564 NA -0.41 -5.07 -0.3 7.45e-7 Hemoglobin concentration; CESC cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg15017067 chr4:17643749 FAM184B 0.4 5.72 0.33 2.8e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4237845 0.804 rs10877034 chr12:58286444 T/C cg00677455 chr12:58241039 CTDSP2 0.42 5.38 0.31 1.6e-7 Intelligence (multi-trait analysis); CESC cis rs9858542 0.953 rs6997 chr3:49453834 C/T cg03060546 chr3:49711283 APEH -0.55 -6.64 -0.38 1.74e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7202877 0.656 rs9923834 chr16:75507253 T/A cg04384234 chr16:75411784 CFDP1 -0.44 -5.42 -0.32 1.34e-7 Type 2 diabetes;Type 1 diabetes; CESC cis rs8114671 0.562 rs1018447 chr20:33401707 A/G cg06115741 chr20:33292138 TP53INP2 -0.42 -5.23 -0.31 3.38e-7 Height; CESC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg06074448 chr4:187884817 NA -0.38 -5.31 -0.31 2.3e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs3806843 0.838 rs2563289 chr5:140122766 T/A cg16179182 chr5:140090404 VTRNA1-1 0.39 5.07 0.3 7.42e-7 Depressive symptoms (multi-trait analysis); CESC cis rs41264869 0.600 rs73083129 chr1:205186206 T/C cg21643547 chr1:205240462 TMCC2 0.35 5.23 0.31 3.44e-7 Blood protein levels; CESC cis rs854765 0.964 rs72827413 chr17:17988299 C/T cg09796270 chr17:17721594 SREBF1 -0.38 -5.16 -0.3 4.76e-7 Total body bone mineral density; CESC cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg26597838 chr10:835615 NA 0.76 7.34 0.41 2.62e-12 Eosinophil percentage of granulocytes; CESC cis rs35306767 0.807 rs61831436 chr10:837882 G/A cg26597838 chr10:835615 NA 1.18 12.03 0.59 6.79e-27 Eosinophil percentage of granulocytes; CESC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.54 0.51 9.59e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg00360600 chr2:38152299 FAM82A1 -0.56 -6.48 -0.37 4.48e-10 Subjective well-being; CESC cis rs2228479 0.850 rs2238525 chr16:89809902 T/C cg00800038 chr16:89945340 TCF25 -0.77 -7.46 -0.42 1.26e-12 Skin colour saturation; CESC cis rs12681366 0.708 rs2930962 chr8:95445505 G/C cg13257157 chr8:95487014 RAD54B 0.38 5.14 0.3 5.25e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16919567 chr17:19015961 NA 0.49 6.39 0.37 7.26e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20017464 chr17:30677219 MIR632;ZNF207 0.45 6.41 0.37 6.63e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12282928 0.704 rs4980430 chr11:48298269 G/A cg26585981 chr11:48327164 OR4S1 -0.38 -5.3 -0.31 2.44e-7 Migraine - clinic-based; CESC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg19454999 chr17:41278357 BRCA1;NBR2 -0.51 -7.24 -0.41 4.98e-12 Menopause (age at onset); CESC trans rs1814175 0.615 rs11040654 chr11:49939485 T/G cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs73206853 0.841 rs73191826 chr12:110943001 G/T cg12870014 chr12:110450643 ANKRD13A 0.63 5.22 0.31 3.56e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs644799 0.710 rs10831433 chr11:95519787 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.73 10.87 0.56 5.24e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2288073 0.965 rs10173173 chr2:24415461 G/T cg06627628 chr2:24431161 ITSN2 0.75 8.99 0.48 4.79e-17 Venous thromboembolism (SNP x SNP interaction); CESC cis rs1801251 1.000 rs283474 chr2:233654627 A/G cg25237894 chr2:233734115 C2orf82 0.46 7.97 0.44 4.73e-14 Coronary artery disease; CESC cis rs919433 0.680 rs7582536 chr2:198436103 C/T cg03934865 chr2:198174659 NA -0.39 -5.27 -0.31 2.83e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs17253792 0.822 rs28513551 chr14:56094993 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg27572855 chr1:25598939 RHD -0.44 -7.2 -0.4 6.33e-12 Erythrocyte sedimentation rate; CESC cis rs3125734 0.633 rs4979773 chr10:63967731 G/C cg09941381 chr10:64027924 RTKN2 -0.32 -5.17 -0.3 4.6e-7 Rheumatoid arthritis; CESC cis rs67311347 1.000 rs28434528 chr3:40484893 A/G cg24209194 chr3:40518798 ZNF619 0.46 5.99 0.35 6.78e-9 Renal cell carcinoma; CESC trans rs4332037 0.707 rs62435130 chr7:1890002 C/T cg11693508 chr17:37793320 STARD3 0.61 6.18 0.35 2.45e-9 Bipolar disorder; CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg12419862 chr22:24373484 LOC391322 0.98 16.37 0.71 4.41e-42 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs910316 0.967 rs4903285 chr14:75609268 A/T cg16144293 chr14:75469539 EIF2B2 -0.39 -5.03 -0.3 9.07e-7 Height; CESC cis rs2243480 1.000 rs778679 chr7:65840911 A/G cg12463550 chr7:65579703 CRCP 0.71 5.49 0.32 9.37e-8 Diabetic kidney disease; CESC trans rs1814175 0.676 rs1851859 chr11:49860405 A/T cg03929089 chr4:120376271 NA -0.89 -14.21 -0.66 1.89e-34 Height; CESC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg01988459 chr11:68622903 NA -0.39 -5.4 -0.31 1.49e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6460942 0.908 rs59410610 chr7:12282847 A/G cg20607287 chr7:12443886 VWDE -0.55 -5.86 -0.34 1.38e-8 Coronary artery disease; CESC cis rs3105593 1.000 rs28817917 chr15:50965846 T/C cg08437265 chr15:50716283 USP8 0.46 6.07 0.35 4.49e-9 QT interval; CESC cis rs2239547 0.603 rs2276825 chr3:52886605 T/C cg11645453 chr3:52864694 ITIH4 0.33 6.08 0.35 4.27e-9 Schizophrenia; CESC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04810377 chr16:11761964 SNN 0.54 6.35 0.36 9.4e-10 Gut microbiome composition (summer); CESC cis rs26868 0.740 rs26869 chr16:2248786 T/C cg02248941 chr16:2239361 CASKIN1 0.39 6.13 0.35 3.13e-9 Height; CESC cis rs17021463 0.615 rs4626213 chr4:95297241 G/A cg11021082 chr4:95130006 SMARCAD1 0.56 7.79 0.43 1.5700000000000001e-13 Testicular germ cell tumor; CESC cis rs7589728 0.858 rs79992736 chr2:88530575 A/C cg18490616 chr2:88469792 THNSL2 0.53 6.01 0.35 6.01e-9 Plasma clusterin levels; CESC cis rs7274811 0.744 rs55651102 chr20:32188068 A/T cg21523528 chr20:32077966 CBFA2T2 0.62 7.16 0.4 7.82e-12 Height; CESC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg07507251 chr3:52567010 NT5DC2 0.42 7.25 0.41 4.61e-12 Bipolar disorder; CESC cis rs7772486 0.686 rs1011596 chr6:146076433 A/G cg05347473 chr6:146136440 FBXO30 0.52 6.8 0.39 6.74e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.3 -0.36 1.2e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4566357 0.930 rs13398295 chr2:227926873 A/G cg11843606 chr2:227700838 RHBDD1 -0.43 -5.45 -0.32 1.16e-7 Coronary artery disease; CESC trans rs1545843 0.564 rs2446668 chr12:84888491 T/C cg03015433 chr16:56623111 MT3 0.34 6.04 0.35 5.19e-9 Major depressive disorder; CESC cis rs965469 0.843 rs6037580 chr20:3351374 A/G cg25506879 chr20:3388711 C20orf194 -0.57 -6.12 -0.35 3.41e-9 IFN-related cytopenia; CESC cis rs1691799 0.867 rs1168356 chr12:66750469 A/G cg16791601 chr12:66731901 HELB -0.62 -10.14 -0.53 1.22e-20 White blood cell count (basophil); CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg10826053 chr4:108641834 PAPSS1 0.44 6.12 0.35 3.4e-9 Positive affect; CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg11905131 chr22:24372483 LOC391322 -0.82 -12.36 -0.6 5.28e-28 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs6716963 0.870 rs6748251 chr2:194468524 A/G cg13252710 chr13:20134915 NA 0.41 6.09 0.35 3.98e-9 Schizophrenia; CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg26335602 chr6:28129616 ZNF389 0.53 6.95 0.39 2.83e-11 Depression; CESC cis rs9302635 0.513 rs8050238 chr16:72154187 C/T cg16558253 chr16:72132732 DHX38 -0.43 -5.52 -0.32 8.09e-8 Blood protein levels; CESC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg11663144 chr21:46675770 NA -0.62 -9.74 -0.51 2.36e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9346455 0.568 rs9364155 chr6:72023794 A/G cg27238071 chr6:71998145 OGFRL1 0.56 5.36 0.31 1.83e-7 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs58235267 0.553 rs1025132 chr2:63360639 G/A cg17519650 chr2:63277830 OTX1 0.56 7.31 0.41 3.18e-12 Prostate-specific antigen levels (conditioned on lead SNPs); CESC cis rs6032067 0.777 rs17423897 chr20:43780307 T/C cg11264863 chr20:43835661 SEMG1 0.5 5.37 0.31 1.75e-7 Blood protein levels; CESC cis rs644799 0.601 rs662168 chr11:95586982 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.57 8.33 0.46 4.41e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs853679 1.000 rs853676 chr6:28299687 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.73 7.43 0.42 1.51e-12 Depression; CESC cis rs17666538 0.585 rs1037393 chr8:622634 G/C cg23958373 chr8:599963 NA 0.82 5.92 0.34 1.02e-8 IgG glycosylation; CESC cis rs1801251 1.000 rs7606090 chr2:233606740 T/C cg25237894 chr2:233734115 C2orf82 0.44 7.57 0.42 6.22e-13 Coronary artery disease; CESC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg06481639 chr22:41940642 POLR3H 0.6 5.91 0.34 1.02e-8 Vitiligo; CESC trans rs637571 0.546 rs10791827 chr11:65596546 C/A cg17712092 chr4:129076599 LARP1B -0.63 -7.96 -0.44 5.2e-14 Eosinophil percentage of white cells; CESC cis rs3762637 1.000 rs9882100 chr3:122169908 T/C cg24169773 chr3:122142474 KPNA1 -0.54 -6.33 -0.36 1.04e-9 LDL cholesterol levels; CESC cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg23711669 chr6:146136114 FBXO30 0.9 13.27 0.63 3.71e-31 Lobe attachment (rater-scored or self-reported); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02294249 chr13:34392492 RFC3 0.47 6.1 0.35 3.71e-9 Gut microbiota (bacterial taxa); CESC trans rs9937837 1.000 rs7499077 chr16:31317505 G/A cg04903759 chr3:167238645 WDR49 0.52 6.55 0.37 3.05e-10 Systemic lupus erythematosus; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13456812 chr6:167369504 RNASET2 -0.43 -6.48 -0.37 4.37e-10 Gambling; CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg18402987 chr7:1209562 NA 0.41 5.3 0.31 2.39e-7 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26291818 chr8:61429582 RAB2A 0.65 7.69 0.43 2.98e-13 Gut microbiome composition (summer); CESC cis rs10979 0.597 rs10782290 chr6:143906340 T/C cg25407410 chr6:143891975 LOC285740 -0.51 -6.75 -0.38 9.09e-11 Hypospadias; CESC cis rs3857536 0.706 rs1418854 chr6:66893284 C/T cg07460842 chr6:66804631 NA -0.42 -5.45 -0.32 1.15e-7 Blood trace element (Cu levels); CESC cis rs10911232 0.507 rs4072709 chr1:183028855 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 13.58 0.64 3e-32 Hypertriglyceridemia; CESC cis rs9611565 0.694 rs79008 chr22:41850500 C/T cg03806693 chr22:41940476 POLR3H -1.13 -14.0 -0.65 1.03e-33 Vitiligo; CESC trans rs9467711 0.606 rs1977 chr6:26377546 A/G cg06606381 chr12:133084897 FBRSL1 -0.74 -7.3 -0.41 3.35e-12 Autism spectrum disorder or schizophrenia; CESC trans rs6952808 1.000 rs10233560 chr7:1885415 T/C cg24247370 chr13:99142703 STK24 -0.41 -6.14 -0.35 2.99e-9 Bipolar disorder and schizophrenia; CESC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg01017244 chr2:74357527 NA 0.74 10.89 0.56 4.72e-23 Gestational age at birth (maternal effect); CESC cis rs826838 1.000 rs10875991 chr12:39108886 G/C cg26384229 chr12:38710491 ALG10B 0.8 13.72 0.64 9.71e-33 Heart rate; CESC cis rs2230307 0.505 rs641458 chr1:100578672 G/C cg24955406 chr1:100503596 HIAT1 -0.53 -5.31 -0.31 2.35e-7 Carotid intima media thickness; CESC cis rs9916302 0.904 rs12450559 chr17:37694709 G/A cg15445000 chr17:37608096 MED1 0.42 6.97 0.39 2.52e-11 Glomerular filtration rate (creatinine); CESC trans rs561341 1.000 rs72821971 chr17:30269343 T/G cg27661571 chr11:113659931 NA -0.83 -7.82 -0.43 1.26e-13 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11208313 chr17:27276484 PHF12 -0.6 -7.02 -0.4 1.9e-11 Gut microbiome composition (summer); CESC cis rs1707322 0.686 rs2991986 chr1:46081282 A/G cg03146154 chr1:46216737 IPP -0.8 -10.89 -0.56 4.66e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1814175 0.588 rs10839463 chr11:49971643 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs7084402 0.934 rs1158212 chr10:60318276 G/A cg07615347 chr10:60278583 BICC1 0.61 9.76 0.51 2.03e-19 Refractive error; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16372595 chr14:20774003 TTC5 0.54 6.85 0.39 5.12e-11 Gut microbiota (bacterial taxa); CESC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg11663144 chr21:46675770 NA -0.63 -9.84 -0.52 1.12e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs28830936 1.000 rs17677991 chr15:42032383 C/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.37 -5.43 -0.32 1.25e-7 Diastolic blood pressure; CESC cis rs11098499 0.820 rs13122709 chr4:120555356 T/A cg24375607 chr4:120327624 NA 0.46 5.72 0.33 2.94e-8 Corneal astigmatism; CESC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg22535103 chr8:58192502 C8orf71 -0.9 -9.52 -0.5 1.13e-18 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg07308232 chr7:1071921 C7orf50 -0.6 -8.45 -0.46 1.94e-15 Longevity;Endometriosis; CESC cis rs9309711 0.772 rs9309714 chr2:3491830 G/C cg10845886 chr2:3471009 TTC15 -0.84 -11.38 -0.57 1.08e-24 Neurofibrillary tangles; CESC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg19346786 chr7:2764209 NA -0.49 -7.09 -0.4 1.19e-11 Height; CESC cis rs3762318 1.000 rs12069782 chr1:67600101 C/T cg17031739 chr1:67600172 NA 0.52 5.55 0.32 7.04e-8 Leprosy; CESC cis rs7631605 0.905 rs11716414 chr3:37258835 G/A cg22985146 chr3:37219077 LRRFIP2 -0.35 -5.45 -0.32 1.14e-7 Cerebrospinal P-tau181p levels; CESC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg02931644 chr1:25747376 RHCE 0.47 7.99 0.44 4.14e-14 Erythrocyte sedimentation rate; CESC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg00339695 chr16:24857497 SLC5A11 0.5 6.53 0.37 3.25e-10 Intelligence (multi-trait analysis); CESC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 6.23 0.36 1.78e-9 Bipolar disorder; CESC cis rs2070488 0.775 rs961179 chr3:38509618 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.83 13.43 0.64 9.82e-32 Electrocardiographic conduction measures; CESC cis rs7192750 0.583 rs2550043 chr16:72067491 T/C cg14768367 chr16:72042858 DHODH 0.73 5.12 0.3 5.88e-7 LDL cholesterol levels;Total cholesterol levels; CESC cis rs3106136 0.967 rs11097409 chr4:95168515 C/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.76 -0.38 8.72e-11 Capecitabine sensitivity; CESC cis rs6565681 1.000 rs6565681 chr17:78348494 A/G cg15383979 chr17:78362278 RNF213;LOC100294362 -0.75 -8.4 -0.46 2.75e-15 Moyamoya disease; CESC cis rs2228479 0.850 rs1800355 chr16:89813194 C/T cg00800038 chr16:89945340 TCF25 -0.88 -7.23 -0.41 5.21e-12 Skin colour saturation; CESC cis rs470119 1.000 rs131801 chr22:50966634 G/T cg12969734 chr22:50962224 SCO2 0.36 5.54 0.32 7.23e-8 Mean corpuscular hemoglobin; CESC cis rs116095464 0.558 rs7708182 chr5:234788 C/G cg20965017 chr5:231967 SDHA -0.45 -5.1 -0.3 6.61e-7 Breast cancer; CESC cis rs2439831 0.850 rs10163054 chr15:44047638 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.7 6.6 0.38 2.25e-10 Lung cancer in ever smokers; CESC cis rs17376456 0.877 rs35747258 chr5:93310129 C/T cg21475434 chr5:93447410 FAM172A 0.76 6.88 0.39 4.31e-11 Diabetic retinopathy; CESC cis rs7666738 0.830 rs17548431 chr4:98923768 C/G cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02737830 chr12:64616354 C12orf66 0.48 6.53 0.37 3.29e-10 Systemic lupus erythematosus; CESC cis rs3106136 0.934 rs17376404 chr4:95224046 T/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.87 -0.39 4.64e-11 Capecitabine sensitivity; CESC cis rs2832191 0.791 rs2832198 chr21:30498240 C/T cg24692254 chr21:30365293 RNF160 0.78 12.04 0.59 6.57e-27 Dental caries; CESC cis rs9488822 0.676 rs1338667 chr6:116323910 T/A cg18764771 chr6:116381957 FRK 0.22 5.44 0.32 1.21e-7 Cholesterol, total;LDL cholesterol; CESC cis rs13102973 0.965 rs13131455 chr4:135883112 A/C cg14419869 chr4:135874104 NA -0.34 -5.37 -0.31 1.73e-7 Subjective well-being; CESC cis rs113835537 0.529 rs11227525 chr11:66308065 T/G cg24851651 chr11:66362959 CCS 0.52 6.23 0.36 1.84e-9 Airway imaging phenotypes; CESC cis rs11098499 0.954 rs3733519 chr4:120423448 A/G cg24375607 chr4:120327624 NA 0.49 6.03 0.35 5.52e-9 Corneal astigmatism; CESC cis rs7267979 0.586 rs6050431 chr20:25183908 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.66 10.78 0.55 1.07e-22 Liver enzyme levels (alkaline phosphatase); CESC cis rs1707322 0.752 rs10789467 chr1:46118745 C/G cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg11764359 chr7:65958608 NA 0.95 14.99 0.68 3.2e-37 Aortic root size; CESC cis rs1005277 0.683 rs7923868 chr10:37989766 T/C cg25427524 chr10:38739819 LOC399744 -0.6 -8.37 -0.46 3.42e-15 Extrinsic epigenetic age acceleration; CESC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg05313129 chr8:58192883 C8orf71 -0.54 -6.23 -0.36 1.82e-9 Developmental language disorder (linguistic errors); CESC cis rs742614 0.533 rs6059498 chr20:32447282 T/C cg06304546 chr20:32448765 NA -0.48 -6.17 -0.35 2.6e-9 Stearic acid (18:0) levels; CESC cis rs798554 1.000 rs798560 chr7:2758309 A/G cg04166393 chr7:2884313 GNA12 0.52 6.53 0.37 3.36e-10 Height; CESC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs12681288 0.862 rs935821 chr8:1022455 G/A cg04851639 chr8:1020857 NA -0.4 -8.95 -0.48 6.31e-17 Schizophrenia; CESC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg04267008 chr7:1944627 MAD1L1 -0.56 -6.59 -0.38 2.37e-10 Bipolar disorder and schizophrenia; CESC cis rs6060717 0.654 rs8122716 chr20:34607001 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -5.6 -0.33 5.45e-8 Hip circumference adjusted for BMI; CESC cis rs7617773 0.817 rs13068265 chr3:48301614 A/C cg11946769 chr3:48343235 NME6 0.86 11.61 0.58 1.78e-25 Coronary artery disease; CESC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg18758796 chr5:131593413 PDLIM4 0.44 6.05 0.35 4.85e-9 Breast cancer; CESC cis rs11098499 0.530 rs114866537 chr4:120258608 A/T cg09307838 chr4:120376055 NA 0.76 10.33 0.54 3.02e-21 Corneal astigmatism; CESC cis rs9905704 0.589 rs2680696 chr17:56473013 C/T cg12560992 chr17:57184187 TRIM37 -0.62 -5.7 -0.33 3.16e-8 Testicular germ cell tumor; CESC cis rs8141529 0.702 rs132536 chr22:29302906 A/G cg15103426 chr22:29168792 CCDC117 -0.61 -8.0 -0.44 4.02e-14 Lymphocyte counts; CESC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg07507251 chr3:52567010 NT5DC2 0.33 5.74 0.33 2.64e-8 Bipolar disorder; CESC cis rs7980687 0.628 rs1727332 chr12:123718301 C/T cg00376283 chr12:123451042 ABCB9 0.68 9.21 0.49 1.04e-17 Height;Educational attainment;Head circumference (infant); CESC cis rs7188697 0.848 rs40187 chr16:58556566 T/C cg02549819 chr16:58548995 SETD6 -0.41 -5.22 -0.31 3.7e-7 QT interval; CESC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg05368731 chr17:41323189 NBR1 0.55 7.65 0.43 3.69e-13 Menopause (age at onset); CESC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg08736216 chr1:53307985 ZYG11A 0.4 6.33 0.36 1.04e-9 Monocyte count; CESC cis rs4835473 0.545 rs10022856 chr4:144714310 A/T cg25736465 chr4:144833511 NA 0.33 5.42 0.32 1.31e-7 Immature fraction of reticulocytes; CESC cis rs17253792 0.822 rs17683728 chr14:56060389 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg08736216 chr1:53307985 ZYG11A 0.36 6.48 0.37 4.55e-10 Monocyte count; CESC cis rs2204008 0.807 rs8186948 chr12:38325101 C/G cg13010199 chr12:38710504 ALG10B 0.44 5.68 0.33 3.51e-8 Bladder cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15598754 chr1:21551903 ECE1 0.47 6.49 0.37 4.16e-10 Fibrinogen levels; CESC cis rs2290159 0.948 rs7956 chr3:12624763 C/T cg23032965 chr3:12705835 RAF1 -0.52 -5.97 -0.34 7.39e-9 Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10360323 chr17:41437877 NA -0.6 -6.85 -0.39 5.04e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25536300 chr19:797459 PTBP1 0.61 7.3 0.41 3.37e-12 Gut microbiome composition (summer); CESC cis rs2249694 0.960 rs7084391 chr10:135412344 A/C cg19469447 chr10:135341870 CYP2E1 0.36 5.09 0.3 6.96e-7 Obesity-related traits; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05972502 chr5:132073061 KIF3A -0.49 -6.17 -0.35 2.55e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06905970 chr19:41222748 ADCK4;ITPKC 0.59 7.27 0.41 4.03e-12 Gut microbiome composition (summer); CESC cis rs854765 0.693 rs12936037 chr17:17777245 A/G cg04398451 chr17:18023971 MYO15A 0.63 8.91 0.48 8.3e-17 Total body bone mineral density; CESC cis rs7824557 0.564 rs2736300 chr8:11235579 T/G cg21775007 chr8:11205619 TDH -0.53 -7.86 -0.44 9.39e-14 Retinal vascular caliber; CESC cis rs34779708 0.931 rs4934535 chr10:35432721 G/T cg04310649 chr10:35416472 CREM -0.51 -6.14 -0.35 3.02e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09192942 chr16:75682004 KARS;TERF2IP 0.59 7.23 0.41 5.1e-12 Gut microbiome composition (summer); CESC cis rs28374715 0.557 rs11855854 chr15:41434729 G/A cg18705301 chr15:41695430 NDUFAF1 -0.82 -10.29 -0.53 4.1e-21 Ulcerative colitis; CESC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg12034118 chr1:209979487 IRF6 0.44 5.41 0.32 1.39e-7 Cleft lip with or without cleft palate; CESC cis rs4523957 0.928 rs8065650 chr17:2180823 A/G cg16513277 chr17:2031491 SMG6 0.6 8.38 0.46 3.16e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11166927 0.703 rs2126128 chr8:140788299 A/G cg16909799 chr8:140841666 TRAPPC9 -0.45 -6.3 -0.36 1.23e-9 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs2243480 1.000 rs160633 chr7:65528228 T/C cg13147721 chr7:65941812 NA -0.91 -9.0 -0.48 4.55e-17 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27401539 chr15:41048027 FAM82A2 -0.59 -6.63 -0.38 1.87e-10 Gut microbiome composition (summer); CESC cis rs11098499 0.954 rs11098526 chr4:120390359 C/T cg09307838 chr4:120376055 NA 0.93 13.11 0.63 1.3e-30 Corneal astigmatism; CESC cis rs61931739 0.817 rs10743842 chr12:34306859 C/T cg19457237 chr12:34500585 NA -0.39 -5.37 -0.31 1.69e-7 Morning vs. evening chronotype; CESC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11750568 0.967 rs10464079 chr5:178525779 G/A cg10208897 chr5:178548229 ADAMTS2 0.37 5.25 0.31 3.17e-7 Height; CESC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg00149659 chr3:10157352 C3orf10 0.71 8.4 0.46 2.72e-15 Alzheimer's disease; CESC cis rs9581857 0.547 rs78273785 chr13:28052884 T/C cg01674679 chr13:27998804 GTF3A -0.65 -5.19 -0.3 4.24e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs9359856 0.529 rs72919916 chr6:90489773 G/A cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.61 -0.38 2.13e-10 Bipolar disorder; CESC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.75 0.43 2.03e-13 Prudent dietary pattern; CESC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg07701084 chr6:150067640 NUP43 0.43 5.85 0.34 1.45e-8 Lung cancer; CESC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg16545954 chr1:2118288 C1orf86 0.37 7.1 0.4 1.18e-11 Height; CESC cis rs3087591 0.960 rs2905793 chr17:29470072 C/T cg24425628 chr17:29625626 OMG;NF1 0.41 5.13 0.3 5.71e-7 Hip circumference; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09564133 chr5:176738847 MXD3 0.45 6.02 0.35 5.84e-9 Systemic lupus erythematosus; CESC trans rs7618501 0.933 rs1128535 chr3:49866392 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.32 0.46 4.72e-15 Intelligence (multi-trait analysis); CESC cis rs2933343 1.000 rs2933343 chr3:128658492 G/A cg25356066 chr3:128598488 ACAD9 0.63 7.66 0.43 3.51e-13 IgG glycosylation; CESC cis rs4950322 0.570 rs72692907 chr1:146773610 A/G cg22381352 chr1:146742008 CHD1L -0.47 -5.11 -0.3 6.24e-7 Protein quantitative trait loci; CESC cis rs7703051 0.901 rs6878990 chr5:74689249 T/C cg03227963 chr5:74354835 NA 0.28 5.06 0.3 7.66e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg02018176 chr4:1364513 KIAA1530 0.41 5.91 0.34 1.04e-8 Longevity; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg03407747 chr17:6899364 ALOX12 -0.41 -6.59 -0.38 2.37e-10 Tonsillectomy; CESC cis rs6963495 0.818 rs1721498 chr7:105178819 A/C cg13798780 chr7:105162888 PUS7 -0.62 -7.29 -0.41 3.68e-12 Bipolar disorder (body mass index interaction); CESC cis rs2124969 0.522 rs6432608 chr2:161034991 C/T cg03641300 chr2:160917029 PLA2R1 -0.38 -5.43 -0.32 1.25e-7 Waist circumference adjusted for body mass index; CESC cis rs7481584 0.924 rs16925010 chr11:3013996 C/T cg25174290 chr11:3078921 CARS -0.43 -5.22 -0.31 3.65e-7 Calcium levels; CESC cis rs796364 0.806 rs79333757 chr2:200915716 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs3820928 0.874 rs10188770 chr2:227877037 G/A cg05526886 chr2:227700861 RHBDD1 -0.46 -5.68 -0.33 3.52e-8 Pulmonary function; CESC cis rs12545109 0.800 rs1913278 chr8:57403725 T/C cg09654669 chr8:57350985 NA -0.57 -7.19 -0.4 6.61e-12 Obesity-related traits; CESC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 12.92 0.62 6.11e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8062405 0.755 rs4788073 chr16:28594549 A/G cg01378222 chr16:28622494 SULT1A1 0.31 5.24 0.31 3.28e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6942756 1.000 rs12112374 chr7:128950071 A/G cg02491457 chr7:128862824 NA -0.67 -9.22 -0.49 9.66e-18 White matter hyperintensity burden; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01604592 chr1:44679056 DMAP1 -0.55 -6.53 -0.37 3.29e-10 Ulcerative colitis; CESC cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg18180107 chr4:99064573 C4orf37 0.39 5.09 0.3 6.82e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.752 rs9901219 chr17:37558369 T/G cg15445000 chr17:37608096 MED1 -0.36 -5.28 -0.31 2.71e-7 Glomerular filtration rate (creatinine); CESC cis rs4699052 0.963 rs6533066 chr4:104163607 C/G cg16532752 chr4:104119610 CENPE -0.38 -5.06 -0.3 7.7e-7 Testicular germ cell tumor; CESC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg06873352 chr17:61820015 STRADA 0.48 7.07 0.4 1.37e-11 Height; CESC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.41 -5.35 -0.31 1.89e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg11764359 chr7:65958608 NA 0.95 15.41 0.69 1.05e-38 Aortic root size; CESC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg07507251 chr3:52567010 NT5DC2 0.41 7.2 0.4 6.38e-12 Bipolar disorder; CESC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg05863683 chr7:1912471 MAD1L1 0.42 6.04 0.35 5.12e-9 Bipolar disorder and schizophrenia; CESC cis rs3020736 0.500 rs4147640 chr22:42485292 T/C cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC cis rs10733682 0.524 rs10987422 chr9:129462687 C/A cg00232160 chr9:129468157 NA 0.42 6.56 0.37 2.75e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9815354 0.812 rs59583650 chr3:41809063 A/G cg03022575 chr3:42003672 ULK4 0.68 6.06 0.35 4.7e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg19163074 chr7:65112434 INTS4L2 -0.46 -5.05 -0.3 8.07e-7 Aortic root size; CESC trans rs10832139 0.553 rs16913431 chr11:13942063 T/G cg11511669 chr12:131556214 GPR133 0.5 6.06 0.35 4.74e-9 P wave terminal force; CESC cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.38 -5.94 -0.34 8.96e-9 Personality dimensions; CESC cis rs4722166 0.508 rs2069832 chr7:22767433 A/G cg05472934 chr7:22766657 IL6 0.84 11.19 0.57 4.68e-24 Lung cancer; CESC cis rs933688 1.000 rs11948075 chr5:90680579 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.99 11.87 0.59 2.36e-26 Smoking behavior; CESC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg16325326 chr1:53192061 ZYG11B 0.61 9.22 0.49 9.55e-18 Monocyte count; CESC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg26408565 chr15:76604113 ETFA -0.41 -6.21 -0.36 2.04e-9 Blood metabolite levels; CESC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg17143192 chr8:8559678 CLDN23 0.78 9.15 0.49 1.62e-17 Obesity-related traits; CESC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg21747405 chr11:67723411 NA -0.43 -6.74 -0.38 1.01e-10 Blood pressure (smoking interaction); CESC cis rs1348850 0.526 rs4144278 chr2:178412378 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.71 6.61 0.38 2.13e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg11644478 chr21:40555479 PSMG1 1.07 17.94 0.74 1.16e-47 Cognitive function; CESC cis rs5769765 0.955 rs8139758 chr22:50261123 G/T cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs7474896 0.583 rs11011346 chr10:38009483 C/T cg00409905 chr10:38381863 ZNF37A -0.49 -5.5 -0.32 8.75e-8 Obesity (extreme); CESC cis rs2288912 0.872 rs9304646 chr19:45450408 T/C cg13119609 chr19:45449297 APOC2 0.51 8.12 0.45 1.76e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs13082711 0.558 rs640912 chr3:27364092 C/A cg02860705 chr3:27208620 NA 0.4 5.33 0.31 2.14e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs929354 0.685 rs1808217 chr7:157002741 T/C cg05182265 chr7:156933206 UBE3C -0.49 -7.25 -0.41 4.51e-12 Body mass index; CESC cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg23158103 chr7:148848205 ZNF398 -0.41 -6.46 -0.37 4.89e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7586879 0.681 rs6752483 chr2:25120086 C/T cg01884057 chr2:25150051 NA 0.36 7.01 0.4 1.97e-11 Body mass index; CESC cis rs2228479 0.850 rs62056102 chr16:89941438 T/C cg06558623 chr16:89946397 TCF25 1.13 8.89 0.48 9.9900000000000006e-17 Skin colour saturation; CESC cis rs6963495 0.818 rs117028299 chr7:105162310 T/C cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs1874326 0.524 rs6947999 chr7:138109868 A/G cg18008034 chr7:138118925 NA -0.41 -5.14 -0.3 5.34e-7 Quantitative traits; CESC cis rs60154123 0.667 rs650854 chr1:210465315 G/C cg22029157 chr1:209979665 IRF6 0.48 5.75 0.33 2.41e-8 Coronary artery disease; CESC cis rs10752881 0.967 rs6695746 chr1:182991355 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.31 0.63 2.66e-31 Colorectal cancer; CESC cis rs796364 1.000 rs166845 chr2:200823360 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.9 9.16 0.49 1.48e-17 Schizophrenia; CESC cis rs1215050 0.682 rs6839343 chr4:98839732 G/A cg05340658 chr4:99064831 C4orf37 0.45 5.08 0.3 6.97e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg00409905 chr10:38381863 ZNF37A -0.47 -6.33 -0.36 1.04e-9 Extrinsic epigenetic age acceleration; CESC cis rs8070128 0.688 rs59304093 chr17:17875407 A/G cg09796270 chr17:17721594 SREBF1 0.43 5.68 0.33 3.48e-8 Total body bone mineral density; CESC cis rs6430585 0.702 rs746857 chr2:136554890 G/A cg07169764 chr2:136633963 MCM6 -1.21 -17.62 -0.73 1.65e-46 Corneal structure; CESC cis rs1018836 0.632 rs9642910 chr8:91475724 G/T cg16814680 chr8:91681699 NA -0.61 -8.4 -0.46 2.8e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg07507251 chr3:52567010 NT5DC2 0.37 7.0 0.39 2.13e-11 Bipolar disorder; CESC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg09658497 chr7:2847517 GNA12 -0.38 -5.33 -0.31 2.08e-7 Height; CESC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 11.01 0.56 1.83e-23 Platelet count; CESC cis rs2845885 0.793 rs3751120 chr11:63884453 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.76 8.93 0.48 7.38e-17 Body mass index; CESC cis rs6570726 0.791 rs1935612 chr6:145906090 T/A cg23711669 chr6:146136114 FBXO30 0.9 13.51 0.64 5.42e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs919433 0.783 rs788007 chr2:198233676 T/G cg20885578 chr2:198174922 NA 0.41 5.36 0.31 1.79e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg26939375 chr7:64535504 NA 0.67 9.52 0.5 1.17e-18 Calcium levels; CESC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg12373951 chr3:133503437 NA 0.41 5.82 0.34 1.73e-8 Iron status biomarkers; CESC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.32 -0.54 3.18e-21 Alzheimer's disease; CESC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg04546413 chr19:29218101 NA 0.56 8.15 0.45 1.43e-14 Methadone dose in opioid dependence; CESC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg27125505 chr17:43679177 LOC644172 0.5 6.72 0.38 1.12e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3824867 0.770 rs11820680 chr11:47452744 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -5.94 -0.34 9.16e-9 Mean corpuscular hemoglobin; CESC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg10691866 chr7:65817282 TPST1 0.33 5.52 0.32 7.93e-8 Aortic root size; CESC cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg03467027 chr4:99064603 C4orf37 0.43 5.28 0.31 2.66e-7 Colonoscopy-negative controls vs population controls; CESC cis rs561341 0.941 rs2428336 chr17:30290577 T/C cg19193384 chr17:30244184 NA -0.63 -6.54 -0.37 3.19e-10 Hip circumference adjusted for BMI; CESC cis rs4481887 0.741 rs11488133 chr1:248548380 T/C cg26353448 chr1:248524236 OR2T4 -0.37 -5.2 -0.3 4.05e-7 Common traits (Other); CESC cis rs561341 1.000 rs527256 chr17:30321293 C/G cg23018236 chr17:30244563 NA -0.52 -5.11 -0.3 6.12e-7 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09444120 chr8:107227878 NA -0.54 -6.32 -0.36 1.09e-9 Gut microbiome composition (summer); CESC cis rs12478296 0.792 rs57482298 chr2:243011148 C/A cg06360820 chr2:242988706 NA -0.93 -9.9 -0.52 7.37e-20 Obesity-related traits; CESC cis rs1669338 0.588 rs7629889 chr3:3187643 C/T cg16797762 chr3:3221439 CRBN -0.57 -6.09 -0.35 3.99e-9 White matter integrity; CESC cis rs68170813 0.641 rs12539895 chr7:107091849 C/A cg02696742 chr7:106810147 HBP1 -0.56 -5.19 -0.3 4.1e-7 Coronary artery disease; CESC cis rs1707322 0.752 rs11211169 chr1:46166709 A/G cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7208859 0.562 rs216408 chr17:28907757 C/G cg17105886 chr17:28927953 LRRC37B2 -0.62 -5.61 -0.33 5e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7568069 0.669 rs12478953 chr2:71618599 T/C cg07138437 chr2:71787615 DYSF -0.3 -5.04 -0.3 8.64e-7 Height; CESC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg18876405 chr7:65276391 NA -0.55 -7.16 -0.4 8.17e-12 Aortic root size; CESC cis rs67311347 0.955 rs6764102 chr3:40378153 C/G cg24209194 chr3:40518798 ZNF619 0.42 5.44 0.32 1.2e-7 Renal cell carcinoma; CESC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg06453172 chr10:134556979 INPP5A 0.42 5.69 0.33 3.41e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs12681288 0.712 rs2600488 chr8:1021266 A/C cg15309053 chr8:964076 NA 0.37 6.5 0.37 4.01e-10 Schizophrenia; CESC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg07414643 chr4:187882934 NA 0.55 7.99 0.44 4.15e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs2115630 0.691 rs2292462 chr15:85200754 G/T cg11189052 chr15:85197271 WDR73 -0.48 -6.54 -0.37 3.08e-10 P wave terminal force; CESC cis rs12681288 0.792 rs4735972 chr8:998618 A/C cg15309053 chr8:964076 NA 0.3 5.25 0.31 3.13e-7 Schizophrenia; CESC cis rs11122272 0.525 rs2739517 chr1:231537914 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.48 -0.42 1.11e-12 Hemoglobin concentration; CESC cis rs7267979 0.966 rs2482948 chr20:25296499 T/C cg08601574 chr20:25228251 PYGB -0.36 -5.13 -0.3 5.74e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01326135 chr16:87351364 NA -0.57 -6.26 -0.36 1.51e-9 Gut microbiome composition (summer); CESC cis rs7914558 1.000 rs12780843 chr10:104769335 G/C cg04362960 chr10:104952993 NT5C2 0.44 5.87 0.34 1.3e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs5758659 0.652 rs133300 chr22:42389839 A/G cg15557168 chr22:42548783 NA -0.45 -6.62 -0.38 1.93e-10 Cognitive function; CESC cis rs9549367 0.713 rs3024745 chr13:113821598 A/G cg18105134 chr13:113819100 PROZ -0.69 -8.26 -0.45 7.09e-15 Platelet distribution width; CESC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg07167872 chr1:205819463 PM20D1 0.76 12.89 0.62 7.57e-30 Menarche (age at onset); CESC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg26314531 chr2:26401878 FAM59B 0.73 7.65 0.43 3.64e-13 Gut microbiome composition (summer); CESC cis rs3768617 0.745 rs4546885 chr1:183025555 C/G ch.1.3577855R chr1:183094577 LAMC1 0.66 9.15 0.49 1.55e-17 Fuchs's corneal dystrophy; CESC cis rs9486719 0.895 rs34051754 chr6:97007754 A/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.69 -0.33 3.43e-8 Migraine;Coronary artery disease; CESC cis rs17253792 0.915 rs78498383 chr14:56177585 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.73 5.13 0.3 5.7e-7 Putamen volume; CESC cis rs6942756 0.747 rs692697 chr7:129112576 C/T cg02491457 chr7:128862824 NA 0.54 7.46 0.42 1.24e-12 White matter hyperintensity burden; CESC cis rs2455799 0.613 rs1532767 chr3:15733600 A/T cg16303742 chr3:15540471 COLQ -0.33 -5.16 -0.3 4.93e-7 Mean platelet volume; CESC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg02461776 chr11:598696 PHRF1 0.47 5.17 0.3 4.67e-7 Systemic lupus erythematosus; CESC cis rs9640161 0.789 rs13223702 chr7:150058968 G/A cg27494647 chr7:150038898 RARRES2 0.44 5.4 0.32 1.45e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs12887734 0.524 rs17791722 chr14:104286210 C/T cg01849466 chr14:104193079 ZFYVE21 -0.42 -5.51 -0.32 8.42e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs1707322 0.721 rs10890343 chr1:46157922 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.73 0.43 2.2e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7044106 0.762 rs10491783 chr9:123450155 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 12.82 0.62 1.3e-29 Hip circumference adjusted for BMI; CESC cis rs1878931 0.697 rs1044390 chr16:3432594 T/A cg22508957 chr16:3507546 NAT15 -0.4 -5.91 -0.34 1.03e-8 Body mass index (adult); CESC cis rs1348850 0.632 rs12467363 chr2:178502512 C/T cg23306229 chr2:178417860 TTC30B 0.6 7.47 0.42 1.18e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs472109 1.000 rs472109 chr11:9770318 G/C cg03108697 chr11:9732066 SWAP70 -0.34 -5.14 -0.3 5.23e-7 Coronary artery disease; CESC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg01238044 chr22:24384105 GSTT1 0.44 5.48 0.32 9.68e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.8 -8.94 -0.48 7.05e-17 Gut microbiome composition (summer); CESC cis rs7818345 1.000 rs11204041 chr8:19291371 G/A cg11303988 chr8:19266685 CSGALNACT1 0.34 6.17 0.35 2.54e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs7481584 0.926 rs10833024 chr11:3010390 C/T cg25174290 chr11:3078921 CARS -0.48 -6.02 -0.35 5.82e-9 Calcium levels; CESC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.36 0.5 3.44e-18 Menopause (age at onset); CESC cis rs6964587 1.000 rs10270598 chr7:91700827 T/C cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.45e-15 Breast cancer; CESC cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg22862634 chr11:62369728 EML3;MTA2 0.42 6.24 0.36 1.69e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9916302 0.800 rs9892675 chr17:37549200 C/T cg07936489 chr17:37558343 FBXL20 0.97 12.55 0.61 1.14e-28 Glomerular filtration rate (creatinine); CESC cis rs2243480 0.803 rs160649 chr7:65543199 C/T cg18252515 chr7:66147081 NA -1.34 -13.59 -0.64 2.89e-32 Diabetic kidney disease; CESC cis rs10979 1.000 rs9376761 chr6:143887165 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13900113 chr1:41131309 RIMS3 0.53 6.38 0.36 7.86e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15440392 chr20:36156634 BLCAP 0.62 6.9 0.39 3.77e-11 Gut microbiome composition (summer); CESC cis rs11997175 0.603 rs6468205 chr8:33778642 T/A ch.8.33884649F chr8:33765107 NA 0.5 5.97 0.34 7.59e-9 Body mass index; CESC cis rs1707322 1.000 rs11211244 chr1:46456673 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10751667 0.666 rs10902239 chr11:946484 A/G cg20946044 chr11:1010712 AP2A2 0.39 5.39 0.31 1.57e-7 Alzheimer's disease (late onset); CESC cis rs3126085 1.000 rs2338556 chr1:152309427 T/A cg03465714 chr1:152285911 FLG 0.42 5.18 0.3 4.36e-7 Atopic dermatitis; CESC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg04518342 chr5:131593106 PDLIM4 0.41 6.09 0.35 3.86e-9 Breast cancer; CESC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg24562669 chr7:97807699 LMTK2 0.48 7.0 0.4 2.09e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs55794721 0.509 rs7554255 chr1:25778106 C/T cg02931644 chr1:25747376 RHCE 0.46 7.97 0.44 4.84e-14 Plateletcrit;Mean corpuscular volume; CESC cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7193541 1.000 rs7193541 chr16:74664743 C/T cg01733217 chr16:74700730 RFWD3 -0.88 -13.3 -0.63 2.91e-31 Multiple myeloma; CESC cis rs66887589 0.967 rs6844263 chr4:120433807 A/G cg09307838 chr4:120376055 NA 0.5 6.74 0.38 9.75e-11 Diastolic blood pressure; CESC cis rs941873 0.805 rs8837 chr10:81114813 C/G cg09469691 chr10:81107165 PPIF 0.55 7.3 0.41 3.43e-12 Height; CESC cis rs2262909 0.962 rs409835 chr19:22230671 T/C cg11619707 chr19:22235551 ZNF257 -0.32 -5.26 -0.31 2.94e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs10751667 0.643 rs10902245 chr11:953014 C/T cg20946044 chr11:1010712 AP2A2 0.39 5.36 0.31 1.83e-7 Alzheimer's disease (late onset); CESC cis rs59698941 0.765 rs12163971 chr5:132226669 C/A cg02081065 chr5:132209139 LEAP2 -0.52 -5.11 -0.3 6.08e-7 Apolipoprotein A-IV levels; CESC cis rs1018697 0.518 rs284843 chr10:104553566 C/T cg04362960 chr10:104952993 NT5C2 -0.55 -6.25 -0.36 1.6e-9 Colorectal adenoma (advanced); CESC cis rs6691722 0.544 rs7551707 chr1:24696892 G/A cg02336364 chr1:24764700 NIPAL3 0.34 6.96 0.39 2.72e-11 Response to interferon beta in multiple sclerosis; CESC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg16743903 chr16:89593216 SPG7 0.46 6.07 0.35 4.51e-9 Multiple myeloma (IgH translocation); CESC cis rs7267979 1.000 rs2258201 chr20:25272490 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs12971120 0.891 rs3794955 chr18:72174827 C/T cg25817165 chr18:72167213 CNDP2 -0.63 -7.69 -0.43 2.8e-13 Refractive error; CESC cis rs10751667 0.961 rs7482484 chr11:927020 C/T cg06064525 chr11:970664 AP2A2 -0.43 -7.7 -0.43 2.8e-13 Alzheimer's disease (late onset); CESC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.09 0.56 9.7e-24 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21943418 chr22:41460240 NA -0.53 -6.07 -0.35 4.32e-9 Gut microbiome composition (summer); CESC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg09359103 chr1:154839909 KCNN3 -0.58 -10.01 -0.52 3.22e-20 Prostate cancer; CESC cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 7.71 0.43 2.56e-13 Schizophrenia; CESC cis rs4523957 0.855 rs143499 chr17:2132324 T/C cg16513277 chr17:2031491 SMG6 0.64 8.9 0.48 9.15e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7100689 0.646 rs7077854 chr10:82124070 C/T cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs3736485 0.934 rs4143723 chr15:51867172 A/G cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs4927850 0.752 rs7624460 chr3:195748530 C/T cg16724585 chr3:197361211 NA -0.56 -7.27 -0.41 4.02e-12 Pancreatic cancer; CESC cis rs3809863 0.602 rs2317677 chr17:45393407 G/A cg08085267 chr17:45401833 C17orf57 -0.68 -9.15 -0.49 1.55e-17 Glaucoma (primary open-angle); CESC cis rs2354432 0.599 rs6693667 chr1:146817245 A/T cg25205988 chr1:146714368 CHD1L 0.8 8.26 0.45 6.93e-15 Mitochondrial DNA levels; CESC cis rs858239 0.539 rs2178140 chr7:23191625 G/C cg23682824 chr7:23144976 KLHL7 0.51 6.77 0.38 8.05e-11 Cerebrospinal fluid biomarker levels; CESC cis rs708547 0.533 rs3806746 chr4:57773330 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.43 5.12 0.3 5.78e-7 Response to bleomycin (chromatid breaks); CESC cis rs9329289 0.632 rs2452187 chr10:2551147 C/G cg15501526 chr10:2543763 NA 0.58 9.24 0.49 8.61e-18 Age-related hearing impairment; CESC cis rs425277 1.000 rs1401138 chr1:2063149 C/T cg04315214 chr1:2043799 PRKCZ -0.43 -5.95 -0.34 8.34e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08720189 chr9:140500208 ARRDC1 0.63 7.35 0.41 2.47e-12 Gut microbiome composition (summer); CESC cis rs6598955 0.724 rs6656716 chr1:26563105 G/A cg04990556 chr1:26633338 UBXN11 -0.78 -11.12 -0.56 7.96e-24 Obesity-related traits; CESC cis rs34779708 0.733 rs60616028 chr10:35543802 G/A cg04310649 chr10:35416472 CREM -0.47 -5.14 -0.3 5.31e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs7937682 0.562 rs12275761 chr11:111367083 T/A cg09085632 chr11:111637200 PPP2R1B 0.58 7.27 0.41 3.98e-12 Primary sclerosing cholangitis; CESC cis rs834811 0.796 rs2349456 chr7:135901545 G/T cg01726295 chr7:135938950 NA -0.38 -6.38 -0.36 8.01e-10 Post-traumatic stress disorder; CESC cis rs78707713 0.560 rs61848436 chr10:71247714 C/T cg12610070 chr10:71211762 TSPAN15 -0.31 -6.47 -0.37 4.69e-10 Venous thromboembolism; CESC trans rs7980799 0.653 rs10844613 chr12:33605362 A/G cg26384229 chr12:38710491 ALG10B -0.55 -7.85 -0.43 1.07e-13 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg09830162 chr16:1889614 FAHD1;C16orf73 0.55 6.16 0.35 2.7e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs2635047 0.624 rs2289036 chr18:44595809 A/T cg19077165 chr18:44547161 KATNAL2 0.39 5.26 0.31 3.03e-7 Educational attainment; CESC cis rs17209837 0.607 rs1558376 chr7:87079103 T/A cg00919237 chr7:87102261 ABCB4 -0.52 -6.67 -0.38 1.45e-10 Gallbladder cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17114573 chr13:108868021 LIG4 -0.42 -6.17 -0.35 2.55e-9 Gambling; CESC cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg13902645 chr11:5959945 NA -0.41 -5.18 -0.3 4.42e-7 DNA methylation (variation); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24333206 chr3:140660642 SLC25A36 -0.49 -6.78 -0.38 7.75e-11 Asthma; CESC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg23281280 chr6:28129359 ZNF389 0.4 5.95 0.34 8.58e-9 Cardiac Troponin-T levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.13.1677809R chr13:106622364 NA 0.45 6.42 0.37 6.13e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3204270 0.639 rs7215738 chr17:79659847 C/T cg18367735 chr17:79674897 NA 0.67 5.65 0.33 4.08e-8 Dental caries; CESC cis rs9457247 1.000 rs376574 chr6:167389956 A/T cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs12681366 0.762 rs67639046 chr8:95385780 G/C cg13257157 chr8:95487014 RAD54B 0.37 5.09 0.3 6.92e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs6598955 0.950 rs6700455 chr1:26545864 T/C cg01614726 chr1:26633154 UBXN11 -0.45 -5.23 -0.31 3.38e-7 Obesity-related traits; CESC cis rs10838687 0.800 rs3729802 chr11:47354068 G/A cg25783544 chr11:47291846 MADD 0.56 6.33 0.36 1.02e-9 Proinsulin levels; CESC cis rs35146811 0.844 rs12705070 chr7:99656927 A/G cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.44 5.52 0.32 7.96e-8 Coronary artery disease; CESC cis rs16854884 0.558 rs60367530 chr3:143719294 G/A cg06585982 chr3:143692056 C3orf58 0.45 5.36 0.31 1.77e-7 Economic and political preferences (feminism/equality); CESC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs2439831 0.867 rs2255042 chr15:43834318 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.72 -9.62 -0.51 5.44e-19 Lung cancer in ever smokers; CESC cis rs929596 0.585 rs2018985 chr2:234648860 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.58 -7.49 -0.42 1.01e-12 Total bilirubin levels in HIV-1 infection; CESC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg18337363 chr3:52569053 NT5DC2 0.28 5.1 0.3 6.43e-7 Electroencephalogram traits; CESC trans rs9354308 0.840 rs17508021 chr6:66569748 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 7.96 0.44 5.21e-14 Metabolite levels; CESC cis rs6570726 1.000 rs441477 chr6:145848243 C/T cg23711669 chr6:146136114 FBXO30 0.78 11.55 0.58 2.8e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs2996428 0.628 rs6667526 chr1:3774603 G/A cg17848003 chr1:3704513 LRRC47 0.39 5.17 0.3 4.62e-7 Red cell distribution width; CESC cis rs1878931 0.501 rs17136359 chr16:3420814 C/T cg05754148 chr16:3507555 NAT15 0.39 5.18 0.3 4.49e-7 Body mass index (adult); CESC trans rs1814175 0.717 rs11040450 chr11:49650638 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -17.65 -0.74 1.25e-46 Height; CESC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg17372223 chr3:52568218 NT5DC2 0.45 6.61 0.38 2.14e-10 Bipolar disorder; CESC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg21724239 chr8:58056113 NA 0.6 5.45 0.32 1.17e-7 Developmental language disorder (linguistic errors); CESC trans rs2121875 0.638 rs10941660 chr5:44223787 G/C cg07292773 chr6:156718177 NA -0.47 -6.09 -0.35 3.99e-9 Prostate cancer; CESC cis rs589448 0.872 rs315111 chr12:69784695 G/A cg14784868 chr12:69753453 YEATS4 0.85 12.93 0.62 5.5e-30 Cerebrospinal fluid biomarker levels; CESC cis rs34779708 0.966 rs11010122 chr10:35493518 A/C cg03585969 chr10:35415529 CREM 0.75 9.89 0.52 7.86e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs8177179 0.904 rs1130459 chr3:133465283 A/G cg17775713 chr3:133465469 TF 0.32 5.71 0.33 3.1e-8 Iron status biomarkers (transferrin levels); CESC trans rs1814175 0.509 rs60698301 chr11:49877672 G/A cg03929089 chr4:120376271 NA -0.87 -14.17 -0.66 2.64e-34 Height; CESC cis rs7095944 0.582 rs10901823 chr10:126488660 C/T cg08799069 chr10:126477246 METTL10 -0.39 -5.58 -0.32 5.92e-8 Asthma; CESC cis rs6987853 0.966 rs2974342 chr8:42436651 A/C cg09913449 chr8:42400586 C8orf40 0.41 6.46 0.37 4.88e-10 Mean corpuscular hemoglobin concentration; CESC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg01017244 chr2:74357527 NA 0.71 10.57 0.54 4.91e-22 Gestational age at birth (maternal effect); CESC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg26441486 chr22:50317300 CRELD2 0.42 5.29 0.31 2.57e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18184349 chr14:75593719 NEK9 0.64 7.4 0.41 1.77e-12 Gut microbiome composition (summer); CESC cis rs523522 0.962 rs1050187 chr12:120902111 A/G cg27279351 chr12:120934652 DYNLL1 -0.7 -8.97 -0.48 5.71e-17 High light scatter reticulocyte count; CESC cis rs644799 0.930 rs3802764 chr11:95514599 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.72 9.58 0.51 7.54e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4843747 0.671 rs28671027 chr16:88116323 G/A cg17633681 chr16:88106987 BANP 0.75 9.98 0.52 4.14e-20 Menopause (age at onset); CESC cis rs79976124 0.797 rs78317899 chr6:66652896 C/A cg07460842 chr6:66804631 NA 0.74 8.77 0.47 2.22e-16 Type 2 diabetes; CESC cis rs1620921 0.505 rs4708888 chr6:161206490 A/C cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs1953600 1.000 rs1953600 chr10:81911725 A/G cg00277334 chr10:82204260 NA 0.45 6.39 0.37 7.3e-10 Sarcoidosis; CESC cis rs116095464 0.558 rs55776650 chr5:273826 G/A cg10591111 chr5:226296 SDHA -0.53 -6.39 -0.37 7.44e-10 Breast cancer; CESC cis rs7917772 0.536 rs4919667 chr10:104426011 A/G cg22532475 chr10:104410764 TRIM8 0.41 6.72 0.38 1.1e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs72945132 0.556 rs57172967 chr11:70160060 G/A cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs2070488 0.804 rs4678605 chr3:38444489 T/A cg24069376 chr3:38537580 EXOG 0.36 6.02 0.35 5.88e-9 Electrocardiographic conduction measures; CESC cis rs870825 0.655 rs2310104 chr4:185619967 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs10927875 0.632 rs904911 chr1:16126932 C/T cg21385522 chr1:16154831 NA -1.03 -16.84 -0.72 9.42e-44 Dilated cardiomyopathy; CESC cis rs2288912 0.807 rs10423208 chr19:45453656 G/A cg09555818 chr19:45449301 APOC2 0.41 6.54 0.37 3.08e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7927771 0.524 rs7124396 chr11:47787434 T/G cg05585544 chr11:47624801 NA -0.32 -5.11 -0.3 6.09e-7 Subjective well-being; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg18345844 chr7:140400218 NDUFB2 0.42 6.35 0.36 9.09e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8077577 0.945 rs11871039 chr17:18078904 C/G cg16794390 chr17:18148240 FLII 0.47 5.89 0.34 1.17e-8 Obesity-related traits; CESC cis rs76878669 0.561 rs4630308 chr11:66162587 G/A cg18002602 chr11:66138449 SLC29A2 0.39 6.41 0.37 6.45e-10 Educational attainment (years of education); CESC cis rs933688 1.000 rs4382199 chr5:90744228 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.16 13.56 0.64 3.5e-32 Smoking behavior; CESC cis rs8060686 0.641 rs113790673 chr16:68244347 C/T cg26727032 chr16:67993705 SLC12A4 -0.53 -5.95 -0.34 8.65e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs10028773 0.666 rs12498657 chr4:120262866 G/C cg25214090 chr10:38739885 LOC399744 0.6 8.26 0.45 6.93e-15 Educational attainment; CESC cis rs8092503 1.000 rs12457101 chr18:52476797 A/G cg12377874 chr18:52495404 RAB27B 0.38 6.27 0.36 1.46e-9 Childhood body mass index; CESC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 21.72 0.8 8.88e-61 Prudent dietary pattern; CESC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg14393609 chr7:65229607 NA -0.47 -6.26 -0.36 1.55e-9 Aortic root size; CESC cis rs1904096 0.506 rs7439869 chr4:95173779 T/C cg11021082 chr4:95130006 SMARCAD1 -0.64 -9.49 -0.5 1.42e-18 Type 2 diabetes; CESC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg09165964 chr15:75287851 SCAMP5 0.46 6.22 0.36 1.97e-9 Breast cancer; CESC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg02569458 chr12:86230093 RASSF9 0.52 7.54 0.42 7.47e-13 Major depressive disorder; CESC cis rs42648 0.869 rs3810890 chr7:89908833 G/T cg23697855 chr7:89950296 NA 0.27 5.14 0.3 5.43e-7 Homocysteine levels; CESC cis rs17345786 1.000 rs55641278 chr3:101290577 G/A cg12386194 chr3:101231763 SENP7 0.59 6.55 0.37 2.93e-10 Colonoscopy-negative controls vs population controls; CESC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg18876405 chr7:65276391 NA -0.46 -6.23 -0.36 1.86e-9 Aortic root size; CESC cis rs2730245 0.527 rs2527187 chr7:158716912 T/C cg24397884 chr7:158709396 WDR60 -0.84 -9.14 -0.49 1.64e-17 Height; CESC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.62 0.47 6.18e-16 Electroencephalogram traits; CESC cis rs1153858 0.887 rs7164139 chr15:45670851 G/A cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg25072359 chr17:41440525 NA 0.47 6.36 0.36 8.86e-10 Menopause (age at onset); CESC cis rs1008375 1.000 rs2058338 chr4:17678600 A/G cg02297831 chr4:17616191 MED28 -0.46 -5.91 -0.34 1.03e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9527 0.590 rs7088200 chr10:104793235 G/A cg04362960 chr10:104952993 NT5C2 0.42 5.42 0.32 1.33e-7 Arsenic metabolism; CESC cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg20573242 chr4:122745356 CCNA2 0.53 6.59 0.38 2.36e-10 Type 2 diabetes; CESC cis rs17666538 0.585 rs6559065 chr8:623156 G/C cg07234876 chr8:600039 NA 0.85 6.02 0.35 5.83e-9 IgG glycosylation; CESC cis rs244293 0.657 rs4829 chr17:53039315 C/T cg19360675 chr17:53046073 COX11;STXBP4 -0.45 -6.14 -0.35 3.02e-9 Menarche (age at onset); CESC cis rs3857067 1.000 rs1397027 chr4:95013562 A/G cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.53 -0.42 8.12e-13 QT interval; CESC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg11890956 chr21:40555474 PSMG1 1.16 21.11 0.79 1.03e-58 Cognitive function; CESC cis rs2404602 0.655 rs4886824 chr15:76969256 A/G cg22467129 chr15:76604101 ETFA -0.34 -5.08 -0.3 7.27e-7 Blood metabolite levels; CESC cis rs7116495 1.000 rs542752 chr11:71810644 T/A cg26138937 chr11:71823887 C11orf51 0.85 6.85 0.39 5.03e-11 Severe influenza A (H1N1) infection; CESC cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg20573242 chr4:122745356 CCNA2 0.63 7.73 0.43 2.3e-13 Type 2 diabetes; CESC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg04267008 chr7:1944627 MAD1L1 -0.75 -9.86 -0.52 9.46e-20 Bipolar disorder and schizophrenia; CESC cis rs2011503 1.000 rs4808970 chr19:19651140 A/G cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg13628971 chr7:2884303 GNA12 0.63 8.14 0.45 1.53e-14 Height; CESC cis rs7692995 1.000 rs7694606 chr4:18028987 G/A cg08925142 chr4:18023851 LCORL -0.43 -5.03 -0.3 9e-7 Height; CESC cis rs7845219 0.544 rs2123647 chr8:95931782 A/G cg23172400 chr8:95962367 TP53INP1 0.38 7.11 0.4 1.09e-11 Type 2 diabetes; CESC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg23172400 chr8:95962367 TP53INP1 -0.46 -9.61 -0.51 5.87e-19 Type 2 diabetes; CESC cis rs9815354 1.000 rs56776628 chr3:41866856 A/G cg03022575 chr3:42003672 ULK4 0.49 5.52 0.32 7.99e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs853679 0.882 rs2743555 chr6:28241081 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.71 7.37 0.41 2.16e-12 Depression; CESC cis rs7843479 0.965 rs13278159 chr8:21799737 C/A cg17168535 chr8:21777572 XPO7 0.51 7.08 0.4 1.32e-11 Mean corpuscular volume; CESC cis rs9815354 0.680 rs73073266 chr3:42021116 A/G cg03022575 chr3:42003672 ULK4 0.74 6.59 0.38 2.33e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.67 6.68 0.38 1.38e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2228479 0.702 rs62056087 chr16:89920383 C/A cg04013166 chr16:89971882 TCF25 0.74 5.83 0.34 1.59e-8 Skin colour saturation; CESC cis rs8038465 0.622 rs56712926 chr15:73886849 G/T cg15420318 chr15:73925796 NPTN 0.49 6.89 0.39 4.17e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6963495 0.818 rs117907809 chr7:105168472 C/A cg19920283 chr7:105172520 RINT1 0.69 6.48 0.37 4.45e-10 Bipolar disorder (body mass index interaction); CESC cis rs3126085 0.935 rs4845733 chr1:152162568 T/C cg03465714 chr1:152285911 FLG -0.43 -5.29 -0.31 2.56e-7 Atopic dermatitis; CESC cis rs367615 0.704 rs11747622 chr5:108844720 G/A cg17395555 chr5:108820864 NA 0.63 11.15 0.57 6.1e-24 Colorectal cancer (SNP x SNP interaction); CESC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg07092213 chr7:1199455 ZFAND2A -0.5 -5.9 -0.34 1.12e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs60154123 0.730 rs588197 chr1:210463515 A/T cg21951975 chr1:209979733 IRF6 0.45 6.26 0.36 1.58e-9 Coronary artery disease; CESC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg22520471 chr17:61851767 DDX42;CCDC47 -0.56 -6.91 -0.39 3.62e-11 Height; CESC cis rs9911578 0.967 rs8182277 chr17:57144367 C/T cg12560992 chr17:57184187 TRIM37 1.01 17.95 0.74 1.13e-47 Intelligence (multi-trait analysis); CESC cis rs116988415 0.584 rs17180252 chr14:65239316 G/A cg25083366 chr14:65239357 SPTB 0.73 5.47 0.32 1.04e-7 Daytime sleep phenotypes; CESC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg14926445 chr8:58193284 C8orf71 -0.49 -5.29 -0.31 2.6e-7 Developmental language disorder (linguistic errors); CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg18337363 chr3:52569053 NT5DC2 0.37 7.29 0.41 3.6e-12 Electroencephalogram traits; CESC cis rs9900062 0.546 rs2676289 chr17:62705738 A/G cg02097616 chr17:62675921 NA -0.44 -5.41 -0.32 1.42e-7 QT interval; CESC cis rs4535700 0.501 rs11765577 chr7:55997938 G/T cg09872392 chr7:56161020 PHKG1 0.41 5.86 0.34 1.41e-8 Macular telangiectasia type 2; CESC cis rs7267979 1.000 rs6515651 chr20:25414539 T/G cg08601574 chr20:25228251 PYGB -0.38 -5.57 -0.32 6.24e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs8077577 0.747 rs8081155 chr17:18191948 C/G cg16794390 chr17:18148240 FLII 0.41 6.45 0.37 5.26e-10 Obesity-related traits; CESC cis rs4919044 0.688 rs59539045 chr10:94776594 C/A cg26979504 chr10:94451518 HHEX -0.47 -5.15 -0.3 5.16e-7 Coronary artery disease; CESC cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.19 0.3 4.29e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg17376030 chr22:41985996 PMM1 -0.56 -6.22 -0.36 1.92e-9 Vitiligo; CESC cis rs9325144 0.555 rs28738714 chr12:38706912 G/A cg26384229 chr12:38710491 ALG10B -0.6 -8.5 -0.46 1.36e-15 Morning vs. evening chronotype; CESC cis rs765787 0.530 rs2433228 chr15:45515371 A/C cg24006582 chr15:45444508 DUOX1 -0.58 -7.12 -0.4 1.04e-11 Uric acid levels; CESC cis rs911555 0.755 rs11620897 chr14:103944861 T/G cg09975044 chr14:104007538 NA 0.43 5.28 0.31 2.68e-7 Intelligence (multi-trait analysis); CESC cis rs6582630 0.555 rs10880611 chr12:38509316 C/G cg13010199 chr12:38710504 ALG10B 0.46 5.91 0.34 1.03e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9486715 0.838 rs9486275 chr6:96901187 C/T cg18709589 chr6:96969512 KIAA0776 0.47 6.61 0.38 2.16e-10 Headache; CESC trans rs1728785 1.000 rs1728801 chr16:68571457 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.44 0.42 1.41e-12 Ulcerative colitis; CESC cis rs9309473 0.607 rs1522926 chr2:73591241 T/C cg20560298 chr2:73613845 ALMS1 -0.46 -6.55 -0.37 3.03e-10 Metabolite levels; CESC cis rs2204008 0.775 rs2387809 chr12:38363338 T/A cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.62e-9 Bladder cancer; CESC cis rs13720 0.915 rs184673 chr20:57567543 A/G cg23907860 chr20:57583709 CTSZ -0.46 -5.5 -0.32 8.93e-8 Platelet distribution width; CESC cis rs3733585 0.605 rs4235354 chr4:10122942 C/A cg11266682 chr4:10021025 SLC2A9 -0.57 -10.19 -0.53 8.72e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs910316 0.737 rs175043 chr14:75471803 G/A cg08847533 chr14:75593920 NEK9 -0.87 -14.32 -0.66 7.93e-35 Height; CESC cis rs7818688 0.614 rs12056808 chr8:95876868 G/A cg16049864 chr8:95962084 TP53INP1 0.51 5.28 0.31 2.7e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg11764359 chr7:65958608 NA 0.96 15.23 0.68 4.78e-38 Aortic root size; CESC cis rs2730245 0.593 rs842699 chr7:158663404 T/A cg24397884 chr7:158709396 WDR60 0.69 10.14 0.53 1.23e-20 Height; CESC cis rs7208859 0.623 rs60890550 chr17:29030861 A/G cg13385521 chr17:29058706 SUZ12P 0.77 6.05 0.35 4.79e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs597539 0.727 rs632984 chr11:68620271 C/T cg21963583 chr11:68658836 MRPL21 0.4 5.42 0.32 1.36e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4566357 0.615 rs3769645 chr2:227913717 A/G cg11843606 chr2:227700838 RHBDD1 -0.48 -6.65 -0.38 1.63e-10 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05917225 chr6:11233042 NEDD9 -0.54 -6.12 -0.35 3.34e-9 Gut microbiome composition (summer); CESC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg24879335 chr3:133465180 TF 0.37 6.45 0.37 5.33e-10 Iron status biomarkers; CESC trans rs6089829 0.962 rs6062778 chr20:61663959 A/G cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg18032046 chr6:28092343 ZSCAN16 0.51 5.83 0.34 1.58e-8 Parkinson's disease; CESC cis rs2361718 0.500 rs4889818 chr17:78085228 A/G cg20811857 chr17:78079795 GAA -0.42 -5.98 -0.34 7.08e-9 Yeast infection; CESC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg09699651 chr6:150184138 LRP11 0.4 5.08 0.3 7.23e-7 Lung cancer; CESC cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.16 0.35 2.75e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7264396 0.690 rs2425165 chr20:34438059 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.35 0.41 2.49e-12 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24615751 chr1:40723984 ZMPSTE24 -0.62 -7.43 -0.42 1.51e-12 Gut microbiome composition (summer); CESC cis rs12410462 1.000 rs75360545 chr1:227625419 T/C cg04117972 chr1:227635322 NA 0.62 6.34 0.36 9.91e-10 Major depressive disorder; CESC cis rs1577917 0.958 rs2875456 chr6:86602284 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.78 -0.33 2.13e-8 Response to antipsychotic treatment; CESC cis rs4595586 0.545 rs11615584 chr12:39409350 C/G cg26384229 chr12:38710491 ALG10B 0.63 8.92 0.48 7.92e-17 Morning vs. evening chronotype; CESC cis rs9322193 0.567 rs7742692 chr6:150213499 A/G cg09699651 chr6:150184138 LRP11 0.53 7.42 0.41 1.6e-12 Lung cancer; CESC cis rs2014572 0.967 rs4801452 chr19:57768066 A/G cg12963866 chr19:57752005 ZNF805 -0.48 -6.5 -0.37 3.96e-10 Hyperactive-impulsive symptoms; CESC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg07701084 chr6:150067640 NUP43 0.46 6.52 0.37 3.54e-10 Lung cancer; CESC cis rs7772486 0.806 rs4075696 chr6:146250947 T/C cg05347473 chr6:146136440 FBXO30 -0.48 -6.42 -0.37 6.21e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg24642844 chr7:1081250 C7orf50 -0.74 -8.93 -0.48 7.18e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10870270 0.956 rs67378218 chr10:133752420 A/C cg17892150 chr10:133769511 PPP2R2D -0.86 -12.71 -0.62 3.22e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.37 -0.54 2.24e-21 Alzheimer's disease; CESC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg05863683 chr7:1912471 MAD1L1 0.43 6.27 0.36 1.45e-9 Bipolar disorder and schizophrenia; CESC cis rs1707322 1.000 rs6661500 chr1:46465662 T/C cg03146154 chr1:46216737 IPP 0.72 9.65 0.51 4.58e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1775715 0.737 rs1419171 chr10:32214831 C/A cg04359828 chr10:32216031 ARHGAP12 0.37 5.15 0.3 5.1e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs950776 0.518 rs1979907 chr15:78842239 T/C cg06917634 chr15:78832804 PSMA4 -0.76 -11.38 -0.57 1.04e-24 Sudden cardiac arrest; CESC cis rs7264396 0.580 rs6060648 chr20:34456704 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.66 6.72 0.38 1.1e-10 Total cholesterol levels; CESC cis rs9303401 0.659 rs34818467 chr17:56643109 C/T cg12560992 chr17:57184187 TRIM37 -0.48 -5.12 -0.3 6e-7 Cognitive test performance; CESC cis rs2228479 0.850 rs11641147 chr16:89813589 C/T cg00800038 chr16:89945340 TCF25 -0.9 -7.51 -0.42 9.11e-13 Skin colour saturation; CESC cis rs7267979 0.714 rs2474763 chr20:25241295 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.71 11.37 0.57 1.18e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg05564831 chr3:52568323 NT5DC2 0.46 6.72 0.38 1.08e-10 Bipolar disorder; CESC trans rs2842169 0.908 rs1025642 chr10:128307100 A/G cg27010096 chr5:1060613 SLC12A7 0.81 6.02 0.35 5.91e-9 Response to radiotherapy in prostate cancer (overall toxicity); CESC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg05234568 chr11:5960015 NA -0.55 -6.89 -0.39 4.14e-11 DNA methylation (variation); CESC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg00310523 chr12:86230176 RASSF9 -0.39 -6.0 -0.35 6.4e-9 Major depressive disorder; CESC cis rs9291683 0.566 rs13115776 chr4:10040189 C/G cg11266682 chr4:10021025 SLC2A9 0.66 12.58 0.61 9.01e-29 Bone mineral density; CESC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg11663144 chr21:46675770 NA -0.63 -9.96 -0.52 4.74e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9649465 1.000 rs2052128 chr7:123380405 T/A cg04330084 chr7:123175371 IQUB -0.38 -5.12 -0.3 5.79e-7 Migraine; CESC cis rs8114671 0.562 rs6087651 chr20:33518353 C/T cg06115741 chr20:33292138 TP53INP2 0.48 5.79 0.34 1.97e-8 Height; CESC cis rs7927771 0.757 rs1057233 chr11:47376448 G/A cg05585544 chr11:47624801 NA 0.48 6.88 0.39 4.3e-11 Subjective well-being; CESC cis rs6500395 0.926 rs9936446 chr16:48645807 G/C cg04672837 chr16:48644449 N4BP1 0.47 5.57 0.32 6.4e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7639513 0.767 rs9861271 chr3:12707620 A/C cg23032965 chr3:12705835 RAF1 0.76 10.86 0.55 5.83e-23 Itch intensity from mosquito bite; CESC cis rs7937682 0.774 rs59921976 chr11:111473088 G/A cg09085632 chr11:111637200 PPP2R1B -0.94 -13.94 -0.65 1.62e-33 Primary sclerosing cholangitis; CESC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg00310523 chr12:86230176 RASSF9 0.35 5.42 0.32 1.35e-7 Major depressive disorder; CESC cis rs4604732 0.578 rs12036417 chr1:247624805 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11166927 0.524 rs2035088 chr8:140831403 A/G cg16909799 chr8:140841666 TRAPPC9 -0.62 -9.68 -0.51 3.66e-19 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg07697082 chr8:82753677 SNX16 -0.38 -5.26 -0.31 3.01e-7 Diastolic blood pressure; CESC cis rs933688 1.000 rs2052553 chr5:90729906 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.13 14.43 0.66 3.18e-35 Smoking behavior; CESC cis rs9457247 0.579 rs2181059 chr6:167441624 T/C cg07741184 chr6:167504864 NA 0.34 6.09 0.35 3.9e-9 Crohn's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24232053 chr12:121177221 ACADS 0.48 6.7 0.38 1.24e-10 Fibrinogen levels; CESC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg20243544 chr17:37824526 PNMT -0.49 -6.21 -0.36 2.05e-9 Glomerular filtration rate (creatinine); CESC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg24562669 chr7:97807699 LMTK2 0.49 7.16 0.4 7.94e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs1538970 0.962 rs4660301 chr1:45820149 T/A cg06784218 chr1:46089804 CCDC17 0.31 5.15 0.3 5.19e-7 Platelet count; CESC cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg03467027 chr4:99064603 C4orf37 0.48 5.95 0.34 8.67e-9 Colonoscopy-negative controls vs population controls; CESC cis rs66887589 0.934 rs56843000 chr4:120516597 T/C cg09307838 chr4:120376055 NA -0.53 -7.07 -0.4 1.35e-11 Diastolic blood pressure; CESC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg08736216 chr1:53307985 ZYG11A -0.4 -6.79 -0.38 7.53e-11 Monocyte count; CESC cis rs35995292 0.534 rs11980627 chr7:38907533 T/C cg19327137 chr7:38886074 VPS41 0.64 10.72 0.55 1.68e-22 Subjective well-being (multi-trait analysis); CESC cis rs739401 0.527 rs423236 chr11:3065916 C/T cg25174290 chr11:3078921 CARS 0.61 8.61 0.47 6.66e-16 Longevity; CESC cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.38 -6.42 -0.37 6.23e-10 Hemoglobin concentration; CESC cis rs9916302 0.629 rs9972882 chr17:37807698 A/C cg07936489 chr17:37558343 FBXL20 -0.55 -6.64 -0.38 1.73e-10 Glomerular filtration rate (creatinine); CESC cis rs61990749 0.544 rs11628888 chr14:78161506 T/C cg21497246 chr14:78225524 SNW1;C14orf178 0.47 5.11 0.3 6.21e-7 Fibroblast growth factor basic levels; CESC cis rs4474465 0.920 rs4945285 chr11:78221698 C/T cg27205649 chr11:78285834 NARS2 0.44 5.27 0.31 2.83e-7 Alzheimer's disease (survival time); CESC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg02428538 chr16:24856791 SLC5A11 0.49 5.09 0.3 6.82e-7 Intelligence (multi-trait analysis); CESC cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg12667521 chr19:29218732 NA 0.48 6.4 0.37 6.97e-10 Methadone dose in opioid dependence; CESC cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs7216064 0.861 rs62084252 chr17:65879578 G/C cg12091567 chr17:66097778 LOC651250 -0.83 -9.53 -0.51 1.07e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg02564969 chr6:151773285 C6orf211;RMND1 0.61 8.46 0.46 1.89e-15 Menarche (age at onset); CESC cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.76 12.28 0.6 9.53e-28 Personality dimensions; CESC cis rs703842 1.000 rs10783848 chr12:58196528 G/A cg18357645 chr12:58087776 OS9 -0.39 -5.56 -0.32 6.57e-8 Multiple sclerosis; CESC cis rs1878931 0.501 rs9921169 chr16:3421261 A/T cg05754148 chr16:3507555 NAT15 -0.39 -5.31 -0.31 2.37e-7 Body mass index (adult); CESC cis rs9815354 0.812 rs77732985 chr3:41945872 G/A cg03022575 chr3:42003672 ULK4 0.71 6.45 0.37 5.42e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs2075371 0.966 rs2544225 chr7:133995838 A/C cg11752832 chr7:134001865 SLC35B4 0.54 7.06 0.4 1.42e-11 Mean platelet volume; CESC cis rs4919044 0.545 rs9420603 chr10:94777490 T/C cg00487187 chr10:94451625 HHEX -0.45 -5.05 -0.3 8.21e-7 Coronary artery disease; CESC cis rs7927771 0.832 rs4992357 chr11:47393638 C/T cg20307385 chr11:47447363 PSMC3 -0.52 -6.25 -0.36 1.6e-9 Subjective well-being; CESC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.34 5.69 0.33 3.42e-8 Bipolar disorder; CESC cis rs17401966 1.000 rs11576866 chr1:10414432 A/G cg15208524 chr1:10270712 KIF1B 0.49 6.27 0.36 1.49e-9 Hepatocellular carcinoma; CESC cis rs57024841 0.562 rs2071006 chr9:139839904 G/T cg00693599 chr9:139836323 FBXW5 -0.43 -6.2 -0.36 2.16e-9 Beta-trace protein levels; CESC cis rs4836694 0.517 rs1017112 chr9:132936804 A/G cg05251000 chr9:132935664 FREQ 0.44 5.87 0.34 1.32e-8 Alzheimer's disease (cognitive decline); CESC cis rs1847202 0.826 rs1979884 chr3:72948515 T/C cg10804678 chr3:72788309 NA -0.38 -5.17 -0.3 4.65e-7 Motion sickness; CESC cis rs9818758 0.607 rs11716445 chr3:49406095 C/T cg00383909 chr3:49044727 WDR6 0.95 6.02 0.35 5.77e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs2250402 0.510 rs2291621 chr15:40324837 C/T cg10636054 chr15:40330586 SRP14 0.95 7.2 0.4 6.08e-12 Corneal curvature; CESC cis rs5758659 0.652 rs133327 chr22:42407689 T/C cg04733989 chr22:42467013 NAGA 0.44 5.85 0.34 1.41e-8 Cognitive function; CESC cis rs6466055 0.720 rs4730080 chr7:105001133 T/C cg04380332 chr7:105027541 SRPK2 -0.42 -5.46 -0.32 1.07e-7 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15606692 chr11:124669480 C11orf61 0.42 6.59 0.38 2.33e-10 Gambling; CESC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg13206674 chr6:150067644 NUP43 0.42 5.83 0.34 1.64e-8 Lung cancer; CESC cis rs9457247 0.663 rs6456143 chr6:167415440 C/A cg07741184 chr6:167504864 NA 0.35 6.24 0.36 1.75e-9 Crohn's disease; CESC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg13206674 chr6:150067644 NUP43 0.44 6.2 0.36 2.19e-9 Lung cancer; CESC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.71 0.62 3.31e-29 Gut microbiome composition (summer); CESC cis rs9814567 1.000 rs7374325 chr3:134275601 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.37 -0.36 8.41e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs3026101 0.671 rs739767 chr17:5290681 A/C cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.69 0.33 3.37e-8 Body mass index; CESC cis rs9911578 1.000 rs7223955 chr17:56917053 C/A cg12560992 chr17:57184187 TRIM37 0.94 15.75 0.7 6.57e-40 Intelligence (multi-trait analysis); CESC cis rs10752881 1.000 rs4420053 chr1:182976133 A/C ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Colorectal cancer; CESC cis rs2228479 0.867 rs34272502 chr16:89949000 G/C cg00800038 chr16:89945340 TCF25 -0.88 -7.85 -0.43 1.01e-13 Skin colour saturation; CESC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg23161317 chr6:28129485 ZNF389 0.37 5.17 0.3 4.53e-7 Cardiac Troponin-T levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21872608 chr12:54121322 CALCOCO1 -0.48 -6.15 -0.35 2.91e-9 Fibrinogen levels; CESC cis rs708547 0.874 rs1401190 chr4:57885174 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.52 -5.51 -0.32 8.64e-8 Response to bleomycin (chromatid breaks); CESC cis rs9858213 1 rs9858213 chr3:49731861 G/T cg07274523 chr3:49395745 GPX1 0.66 8.37 0.46 3.45e-15 Educational attainment; CESC cis rs61935443 0.832 rs7308359 chr12:95272904 G/T cg21533806 chr12:95267307 NA 0.55 6.85 0.39 5e-11 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18073432 chr5:86180679 NA -0.43 -6.14 -0.35 2.97e-9 Gut microbiota (bacterial taxa); CESC trans rs208520 0.690 rs207102 chr6:66795671 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.83 -0.62 1.2e-29 Exhaled nitric oxide output; CESC cis rs9400271 0.632 rs6930698 chr6:109590304 A/G cg01475377 chr6:109611718 NA -0.46 -7.13 -0.4 9.29e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs11158198 0.738 rs910880 chr14:58571274 G/A cg15908186 chr14:58618357 C14orf37 0.34 5.17 0.3 4.73e-7 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg00622204 chr4:107238002 TBCK;AIMP1 0.46 6.18 0.35 2.43e-9 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13790785 chr9:68412296 NA -0.44 -6.16 -0.35 2.75e-9 Gut microbiome composition (summer); CESC cis rs66573146 1.000 rs6838250 chr4:6973184 C/G cg00086871 chr4:6988644 TBC1D14 1.07 6.24 0.36 1.72e-9 Granulocyte percentage of myeloid white cells; CESC cis rs3857536 0.706 rs7755994 chr6:66891747 T/C cg07460842 chr6:66804631 NA -0.4 -5.23 -0.31 3.47e-7 Blood trace element (Cu levels); CESC cis rs2836633 0.929 rs62217518 chr21:40033189 T/G cg12884169 chr21:40033163 ERG 0.38 5.99 0.35 6.69e-9 Coronary artery disease; CESC trans rs4498364 0.541 rs1206156 chr6:97550063 T/G cg09636063 chr6:158957850 TMEM181 0.43 6.12 0.35 3.33e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs2304069 0.954 rs10068537 chr5:149403193 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.86 10.92 0.56 3.63e-23 HIV-1 control; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg21584983 chr19:11640070 ECSIT 0.47 6.63 0.38 1.83e-10 Systemic lupus erythematosus; CESC cis rs67478160 0.595 rs67768834 chr14:104221085 C/G cg08213375 chr14:104286397 PPP1R13B 0.55 11.19 0.57 4.64e-24 Schizophrenia; CESC cis rs9457247 0.663 rs2282861 chr6:167440128 C/T cg23791538 chr6:167370224 RNASET2 -0.57 -7.7 -0.43 2.7e-13 Crohn's disease; CESC cis rs10876993 0.784 rs10083154 chr12:58020933 G/A cg18357645 chr12:58087776 OS9 -0.57 -8.67 -0.47 4.36e-16 Celiac disease or Rheumatoid arthritis; CESC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg04166393 chr7:2884313 GNA12 0.52 6.62 0.38 2.01e-10 Height; CESC cis rs6831352 0.918 rs4699714 chr4:100060538 A/G cg13256891 chr4:100009986 ADH5 -0.75 -8.21 -0.45 9.89e-15 Alcohol dependence; CESC cis rs2288327 0.643 rs1559908 chr2:179336347 C/T cg11548914 chr2:179343871 FKBP7;PLEKHA3;MIR548N -0.49 -5.12 -0.3 6e-7 Atrial fibrillation; CESC cis rs4423214 0.610 rs3763856 chr11:71125345 G/A cg05163923 chr11:71159392 DHCR7 0.61 8.03 0.44 3.1e-14 Vitamin D levels; CESC cis rs8017423 0.647 rs1958346 chr14:90824011 G/T cg14092571 chr14:90743983 NA 0.44 6.77 0.38 8.12e-11 Mortality in heart failure; CESC cis rs2415984 0.622 rs2123126 chr14:46926609 C/T cg14871534 chr14:47121158 RPL10L -0.36 -5.29 -0.31 2.51e-7 Number of children ever born; CESC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg18350739 chr11:68623251 NA -0.44 -6.89 -0.39 3.96e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06938235 chr12:56498303 PA2G4 -0.46 -6.03 -0.35 5.46e-9 Fibrinogen levels; CESC cis rs3806843 1.000 rs10477034 chr5:140169730 A/G cg26395211 chr5:140044315 WDR55 -0.43 -5.46 -0.32 1.1e-7 Depressive symptoms (multi-trait analysis); CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg23093116 chr1:117489843 PTGFRN 0.43 6.22 0.36 1.97e-9 Post-traumatic stress disorder; CESC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.27 0.41 4.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12142240 0.698 rs17361833 chr1:46828700 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.01 0.44 3.75e-14 Menopause (age at onset); CESC cis rs3733585 0.673 rs4314284 chr4:9956096 C/T cg00071950 chr4:10020882 SLC2A9 -0.68 -11.25 -0.57 2.91e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs17508449 0.865 rs75419513 chr1:114132796 A/T cg23028848 chr11:57092561 TNKS1BP1 -0.79 -6.26 -0.36 1.54e-9 Leprosy; CESC cis rs6430585 0.583 rs2304371 chr2:136561557 A/G cg07169764 chr2:136633963 MCM6 1.11 15.69 0.69 1.11e-39 Corneal structure; CESC cis rs712039 0.652 rs2946340 chr17:35749716 C/T cg16670864 chr17:35848621 DUSP14 0.46 5.94 0.34 8.79e-9 Tuberculosis; CESC cis rs2839186 0.605 rs2839170 chr21:47671305 A/G cg10351095 chr21:47802916 PCNT -0.47 -6.32 -0.36 1.13e-9 Testicular germ cell tumor; CESC cis rs4072980 0.545 rs12120737 chr1:38422544 C/T cg26528311 chr1:38462546 FHL3 0.35 5.4 0.31 1.48e-7 Coronary artery disease; CESC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 11.36 0.57 1.25e-24 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06950873 chr5:170814540 NPM1 0.53 6.01 0.35 6.26e-9 Gut microbiome composition (summer); CESC cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg15782153 chr7:917662 C7orf20 0.5 5.32 0.31 2.23e-7 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18805285 chr7:152134019 FABP5L3;MLL3 0.57 6.27 0.36 1.43e-9 Gut microbiome composition (summer); CESC cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg05585544 chr11:47624801 NA 0.46 6.82 0.39 6.06e-11 Subjective well-being; CESC cis rs1879734 0.773 rs4927025 chr1:54131753 C/T cg23596471 chr1:54105337 GLIS1 0.35 5.41 0.32 1.39e-7 Mitral valve prolapse; CESC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg11890956 chr21:40555474 PSMG1 -0.94 -15.15 -0.68 8.9e-38 Cognitive function; CESC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg22903471 chr2:27725779 GCKR -0.51 -7.16 -0.4 7.71e-12 Total body bone mineral density; CESC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg03146154 chr1:46216737 IPP -0.44 -5.5 -0.32 9.01e-8 High light scatter reticulocyte count; CESC cis rs2204008 0.774 rs12810027 chr12:38212165 A/G cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs9623117 0.958 rs7288667 chr22:40464936 A/G cg05033341 chr22:40419857 FAM83F -0.43 -5.24 -0.31 3.28e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg18876405 chr7:65276391 NA 0.48 6.31 0.36 1.16e-9 Aortic root size; CESC cis rs2072499 1.000 rs2072499 chr1:156169610 A/G cg25208724 chr1:156163844 SLC25A44 0.98 18.17 0.74 1.8e-48 Testicular germ cell tumor; CESC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.11 19.57 0.77 2.18e-53 Height; CESC cis rs2228479 0.702 rs2074903 chr16:89811663 T/C cg14709524 chr16:89940631 TCF25 0.95 7.1 0.4 1.18e-11 Skin colour saturation; CESC cis rs6688613 0.694 rs12062326 chr1:166820186 G/A cg07049167 chr1:166818506 POGK 0.52 6.41 0.37 6.8e-10 Refractive astigmatism; CESC cis rs6547741 1.000 rs1919125 chr2:27801403 C/G cg27432699 chr2:27873401 GPN1 0.5 7.01 0.4 2.01e-11 Oral cavity cancer; CESC cis rs11122272 0.735 rs2244994 chr1:231537127 C/G cg06096015 chr1:231504339 EGLN1 0.43 6.08 0.35 4.22e-9 Hemoglobin concentration; CESC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg06634786 chr22:41940651 POLR3H -0.64 -6.72 -0.38 1.11e-10 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20361540 chr12:123380447 VPS37B 0.57 6.3 0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs1387259 0.899 rs7307566 chr12:48604682 A/G cg24011408 chr12:48396354 COL2A1 0.43 6.11 0.35 3.5e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs2228479 0.850 rs45567439 chr16:89814604 G/A cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs7615952 0.611 rs2971298 chr3:125602713 G/A cg05084668 chr3:125655381 ALG1L -0.59 -6.82 -0.39 5.98e-11 Blood pressure (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02166927 chr17:18761443 PRPSAP2 0.64 7.47 0.42 1.14e-12 Gut microbiome composition (summer); CESC cis rs9302635 0.513 rs7184169 chr16:72152933 C/T cg16558253 chr16:72132732 DHX38 -0.46 -5.9 -0.34 1.11e-8 Blood protein levels; CESC cis rs10504229 0.724 rs72649117 chr8:58037639 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -5.84 -0.34 1.53e-8 Developmental language disorder (linguistic errors); CESC cis rs7116495 0.609 rs73543640 chr11:71834374 G/T cg26138937 chr11:71823887 C11orf51 1.23 7.77 0.43 1.75e-13 Severe influenza A (H1N1) infection; CESC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg11764359 chr7:65958608 NA 0.67 8.42 0.46 2.4e-15 Aortic root size; CESC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03934478 chr11:495069 RNH1 -0.56 -5.38 -0.31 1.63e-7 Body mass index; CESC cis rs950776 0.518 rs12591557 chr15:78811732 A/G cg24631222 chr15:78858424 CHRNA5 -0.4 -5.09 -0.3 6.79e-7 Sudden cardiac arrest; CESC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg22433210 chr17:43662623 NA -0.59 -7.57 -0.42 6.02e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs870825 0.616 rs28442259 chr4:185646962 T/G cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg24675658 chr1:53192096 ZYG11B 0.64 8.84 0.48 1.36e-16 Monocyte count; CESC cis rs116095464 0.558 rs10057674 chr5:266813 C/T cg20965017 chr5:231967 SDHA -0.48 -5.43 -0.32 1.25e-7 Breast cancer; CESC cis rs921665 0.831 rs921666 chr2:3192141 G/C cg02624386 chr2:3182749 NA 0.53 5.17 0.3 4.68e-7 World class endurance athleticism; CESC cis rs61931739 0.500 rs11053198 chr12:34444013 G/C cg23762105 chr12:34175262 ALG10 -0.4 -5.22 -0.31 3.7e-7 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00367532 chr15:74703141 SEMA7A 0.42 6.12 0.35 3.38e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04306489 chr17:16593582 CCDC144A -0.55 -6.55 -0.37 3.01e-10 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg12463550 chr7:65579703 CRCP -0.57 -7.35 -0.41 2.54e-12 Aortic root size; CESC cis rs7267979 0.527 rs6076369 chr20:25576783 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.69 -10.95 -0.56 2.95e-23 Liver enzyme levels (alkaline phosphatase); CESC cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg04455712 chr21:45112962 RRP1B 0.34 5.21 0.3 3.84e-7 Mean corpuscular volume; CESC cis rs7829975 0.742 rs12547493 chr8:8661534 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -5.54 -0.32 7.44e-8 Mood instability; CESC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.92 -13.55 -0.64 3.81e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11792861 0.816 rs11791845 chr9:111683898 G/A cg13535736 chr9:111863775 C9orf5 -0.46 -6.11 -0.35 3.51e-9 Menarche (age at onset); CESC cis rs8017423 0.967 rs59006192 chr14:90706456 C/T cg14092571 chr14:90743983 NA -0.58 -8.54 -0.46 1.04e-15 Mortality in heart failure; CESC cis rs6964587 0.869 rs2374519 chr7:91541481 T/C cg17063962 chr7:91808500 NA -0.53 -7.17 -0.4 7.67e-12 Breast cancer; CESC cis rs28647808 0.881 rs28494844 chr9:136266188 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.42 -0.32 1.33e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg07697082 chr8:82753677 SNX16 0.38 5.94 0.34 9.05e-9 Diastolic blood pressure; CESC cis rs4076764 0.958 rs12022261 chr1:163398422 A/G cg24596788 chr1:163392923 NA -0.5 -7.17 -0.4 7.57e-12 Motion sickness; CESC cis rs1707322 0.752 rs11211168 chr1:46163647 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.24 0.41 4.84e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs892961 1.000 rs1075457 chr17:75400737 A/G cg05865280 chr17:75406074 SEPT9 -0.62 -11.76 -0.59 5.74e-26 Airflow obstruction; CESC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg17724175 chr1:150552817 MCL1 0.44 7.24 0.41 4.91e-12 Tonsillectomy; CESC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg08736216 chr1:53307985 ZYG11A 0.36 6.32 0.36 1.09e-9 Monocyte count; CESC cis rs734999 0.572 rs2985857 chr1:2532624 C/T cg20673091 chr1:2541236 MMEL1 -0.44 -7.14 -0.4 8.9e-12 Ulcerative colitis; CESC cis rs938554 0.571 rs7696092 chr4:10025320 C/A cg02734326 chr4:10020555 SLC2A9 0.48 5.48 0.32 9.91e-8 Blood metabolite levels; CESC cis rs7246657 0.943 rs10422074 chr19:37894236 T/C cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.22e-9 Coronary artery calcification; CESC cis rs986417 0.901 rs8020084 chr14:61001495 C/T cg00859478 chr14:60978094 SIX6 0.45 5.12 0.3 5.82e-7 Gut microbiota (bacterial taxa); CESC cis rs9457247 0.765 rs10946203 chr6:167446735 A/C cg07741184 chr6:167504864 NA 0.35 6.32 0.36 1.11e-9 Crohn's disease; CESC cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg20135002 chr11:47629003 NA -0.4 -5.11 -0.3 6.04e-7 Subjective well-being; CESC cis rs6598955 0.671 rs17163751 chr1:26568698 A/G cg19743891 chr1:26644573 UBXN11;CD52 0.38 5.44 0.32 1.21e-7 Obesity-related traits; CESC cis rs6570726 0.935 rs406343 chr6:145874388 A/G cg05347473 chr6:146136440 FBXO30 0.47 6.36 0.36 8.62e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12931616 chr22:38528856 PLA2G6 -0.58 -6.81 -0.39 6.6e-11 Gut microbiome composition (summer); CESC cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 8.74 0.47 2.72e-16 Hip circumference adjusted for BMI; CESC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg24549020 chr5:56110836 MAP3K1 0.65 7.56 0.42 6.72e-13 Initial pursuit acceleration; CESC cis rs7582720 0.887 rs115600411 chr2:204121145 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 6.77 0.38 8.4e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6582630 0.519 rs8186881 chr12:38310285 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.79 0.34 1.95e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9672608 0.687 rs5019044 chr15:78796282 T/A cg24631222 chr15:78858424 CHRNA5 0.63 7.03 0.4 1.79e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs10857712 0.754 rs1052582 chr10:135233840 C/G cg01444801 chr10:135216882 MTG1 -0.45 -5.3 -0.31 2.45e-7 Systemic lupus erythematosus; CESC cis rs6540559 0.673 rs17015330 chr1:210012795 T/G cg23283495 chr1:209979779 IRF6 0.48 5.58 0.32 5.98e-8 Cleft lip with or without cleft palate; CESC cis rs8062405 0.755 rs4788073 chr16:28594549 A/G cg07382826 chr16:28625726 SULT1A1 0.4 6.72 0.38 1.11e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg19077165 chr18:44547161 KATNAL2 0.48 6.43 0.37 5.81e-10 Personality dimensions; CESC cis rs7147624 1.000 rs2411354 chr14:66062132 T/C cg03016385 chr14:66212404 NA -0.5 -5.21 -0.3 3.86e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9910055 0.573 rs228768 chr17:42191893 A/C cg13607699 chr17:42295918 UBTF 0.59 7.78 0.43 1.64e-13 Total body bone mineral density; CESC cis rs7246865 0.510 rs2305757 chr19:17169758 G/C cg16202187 chr19:17186497 HAUS8;MYO9B 0.49 6.38 0.37 7.74e-10 Reticulocyte fraction of red cells; CESC cis rs7503807 0.651 rs901065 chr17:78599655 G/T cg09596252 chr17:78655493 RPTOR 0.39 5.43 0.32 1.3e-7 Obesity; CESC cis rs7520050 0.931 rs35743647 chr1:46407252 T/C cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.66e-9 Red blood cell count;Reticulocyte count; CESC cis rs12618769 0.597 rs3769743 chr2:99063653 C/T cg10123293 chr2:99228465 UNC50 0.41 5.42 0.32 1.31e-7 Bipolar disorder; CESC cis rs78456975 0.699 rs17091772 chr2:1519679 A/C cg01028140 chr2:1542097 TPO -0.47 -5.34 -0.31 1.99e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7223966 1.000 rs15637 chr17:61772050 C/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.58 -0.32 5.85e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs72945132 0.882 rs59398290 chr11:70134819 G/A cg14191688 chr11:70257035 CTTN 0.41 5.27 0.31 2.9e-7 Coronary artery disease; CESC cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg14820908 chr5:178986412 RUFY1 0.38 5.34 0.31 2.03e-7 Lung cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg21815882 chr7:26241064 CBX3;HNRNPA2B1 0.49 6.45 0.37 5.2e-10 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14765172 chr6:153304972 FBXO5 -0.67 -8.01 -0.44 3.69e-14 Gut microbiome composition (summer); CESC cis rs7103648 0.966 rs10769263 chr11:47417183 A/C cg20307385 chr11:47447363 PSMC3 0.96 16.71 0.72 2.58e-43 Diastolic blood pressure;Systolic blood pressure; CESC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg24733560 chr20:60626293 TAF4 0.44 6.03 0.35 5.46e-9 Body mass index; CESC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.74 0.33 2.63e-8 Menopause (age at onset); CESC cis rs57506017 0.585 rs11509137 chr7:12263799 T/C cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.47e-7 Neuroticism; CESC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg25204440 chr1:209979598 IRF6 0.56 5.47 0.32 1.02e-7 Cleft lip with or without cleft palate; CESC cis rs853679 0.546 rs35016036 chr6:28314880 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.87 5.95 0.34 8.27e-9 Depression; CESC cis rs7772486 0.623 rs735535 chr6:146036829 C/T cg05347473 chr6:146136440 FBXO30 -0.53 -6.99 -0.39 2.19e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7829975 0.840 rs555617 chr8:8592845 C/G cg17143192 chr8:8559678 CLDN23 -0.46 -5.67 -0.33 3.71e-8 Mood instability; CESC cis rs7772486 0.846 rs2144478 chr6:146381445 A/G cg23711669 chr6:146136114 FBXO30 0.78 11.55 0.58 2.95e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs6693567 0.526 rs698918 chr1:150319762 A/G cg09579323 chr1:150459698 TARS2 0.49 6.28 0.36 1.35e-9 Migraine; CESC cis rs7927771 1.000 rs35902101 chr11:47795169 C/T cg20307385 chr11:47447363 PSMC3 -0.51 -6.25 -0.36 1.62e-9 Subjective well-being; CESC cis rs9814567 1.000 rs9835204 chr3:134261342 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.15 -0.35 2.87e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs5769765 0.773 rs7290751 chr22:50318312 T/C cg02269571 chr22:50332266 NA -0.56 -6.5 -0.37 3.94e-10 Schizophrenia; CESC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs921968 0.643 rs2178019 chr2:219316303 G/A cg02176678 chr2:219576539 TTLL4 0.36 6.2 0.36 2.15e-9 Mean corpuscular hemoglobin concentration; CESC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg03806693 chr22:41940476 POLR3H -1.23 -17.18 -0.73 5.78e-45 Vitiligo; CESC cis rs1215050 0.740 rs783932 chr4:98973936 C/G cg05340658 chr4:99064831 C4orf37 -0.56 -7.55 -0.42 7e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs3820068 0.603 rs72647138 chr1:15980929 C/T cg17385448 chr1:15911702 AGMAT 0.42 6.89 0.39 4.17e-11 Systolic blood pressure; CESC cis rs72781680 0.699 rs72796125 chr2:23919169 C/T cg20701182 chr2:24300061 SF3B14 0.79 6.88 0.39 4.25e-11 Lymphocyte counts; CESC cis rs875971 0.545 rs12671152 chr7:65776127 G/T cg11764359 chr7:65958608 NA 0.81 9.31 0.5 5.14e-18 Aortic root size; CESC cis rs2739330 0.892 rs5751776 chr22:24266954 A/C cg10819733 chr22:24237672 NA -0.41 -5.91 -0.34 1.05e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2408955 0.522 rs2051851 chr12:48485940 G/C cg24011408 chr12:48396354 COL2A1 -0.49 -7.34 -0.41 2.63e-12 Glycated hemoglobin levels; CESC cis rs6060717 0.654 rs6060686 chr20:34512606 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -9.3 -0.5 5.39e-18 Hip circumference adjusted for BMI; CESC trans rs2727020 0.521 rs11040408 chr11:49534880 A/T cg15704280 chr7:45808275 SEPT13 0.72 9.04 0.49 3.3e-17 Coronary artery disease; CESC cis rs6840258 1.000 rs7682652 chr4:87913444 C/T cg08197287 chr4:87952173 AFF1 -0.42 -5.71 -0.33 3.09e-8 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs2985684 0.901 rs7146248 chr14:50112067 C/T cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.46 -5.36 -0.31 1.83e-7 Carotid intima media thickness; CESC cis rs4975709 0.959 rs9312959 chr5:1877008 G/A cg15595755 chr5:1867978 NA 0.46 7.33 0.41 2.84e-12 Cardiovascular disease risk factors; CESC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg24733560 chr20:60626293 TAF4 0.44 6.54 0.37 3.15e-10 Body mass index; CESC cis rs3026101 0.671 rs1989946 chr17:5313152 T/A cg25236894 chr17:5323110 RPAIN;NUP88 0.45 6.03 0.35 5.47e-9 Body mass index; CESC cis rs2019216 0.524 rs1518049 chr17:21922055 C/T cg22648282 chr17:21454238 C17orf51 -0.43 -5.67 -0.33 3.72e-8 Pelvic organ prolapse; CESC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg25036284 chr2:26402008 FAM59B 0.86 9.4 0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs12540874 0.698 rs13234331 chr7:50560314 G/T cg18232548 chr7:50535776 DDC -0.41 -5.73 -0.33 2.74e-8 Systemic sclerosis; CESC cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg16339924 chr4:17578868 LAP3 0.83 10.53 0.54 6.69e-22 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs12479064 0.694 rs4341989 chr2:100046783 C/T cg20598333 chr11:3663511 ART5 0.49 6.0 0.35 6.48e-9 Chronic sinus infection; CESC cis rs9796 0.689 rs28409432 chr15:41447454 G/A cg12426344 chr15:41135900 SPINT1 -0.25 -5.51 -0.32 8.63e-8 Menopause (age at onset); CESC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg09877947 chr5:131593287 PDLIM4 0.45 5.77 0.33 2.21e-8 Breast cancer; CESC cis rs2273669 0.667 rs7765732 chr6:109347057 A/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs7726839 0.574 rs12517345 chr5:628294 G/A cg16447950 chr5:562315 NA -0.58 -5.87 -0.34 1.3e-8 Obesity-related traits; CESC cis rs16854884 0.632 rs35362423 chr3:143687441 C/A cg06585982 chr3:143692056 C3orf58 0.48 6.01 0.35 6.11e-9 Economic and political preferences (feminism/equality); CESC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg06577658 chr19:46296270 DMWD 0.43 5.2 0.3 3.94e-7 Coronary artery disease; CESC cis rs7635838 0.750 rs2648463 chr3:11403857 G/A cg00170343 chr3:11313890 ATG7 0.5 7.09 0.4 1.25e-11 HDL cholesterol; CESC cis rs2228479 1.000 rs62052213 chr16:89991963 C/T cg04013166 chr16:89971882 TCF25 0.79 6.58 0.37 2.57e-10 Skin colour saturation; CESC cis rs9660992 0.710 rs1172136 chr1:205247097 T/G cg00857998 chr1:205179979 DSTYK 0.46 5.21 0.3 3.77e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs3806843 0.868 rs2531349 chr5:140120953 G/A cg26395211 chr5:140044315 WDR55 0.43 5.59 0.32 5.69e-8 Depressive symptoms (multi-trait analysis); CESC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg24399712 chr22:39784796 NA 0.75 9.77 0.51 1.92e-19 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs5769765 0.671 rs138833 chr22:50178917 A/G cg02269571 chr22:50332266 NA -0.45 -5.89 -0.34 1.17e-8 Schizophrenia; CESC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.76 9.74 0.51 2.37e-19 Height; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20306180 chr22:32340197 C22orf24;YWHAH -0.44 -6.14 -0.35 2.92e-9 Asthma; CESC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg24399712 chr22:39784796 NA -0.83 -11.2 -0.57 4.21e-24 Intelligence (multi-trait analysis); CESC cis rs12142240 0.698 rs7515284 chr1:46809419 A/G cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs10789491 1.000 rs2083485 chr1:47170091 G/C cg15501359 chr1:47185051 KIAA0494 0.79 8.81 0.48 1.66e-16 Response to hepatitis C treatment; CESC cis rs2204008 0.837 rs12369089 chr12:38060263 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.3100000000000001e-10 Bladder cancer; CESC cis rs7091068 0.567 rs1572773 chr10:95432968 T/C cg20715218 chr10:95462985 C10orf4 0.47 6.07 0.35 4.47e-9 Urinary tract infection frequency; CESC trans rs13098911 0.540 rs17282238 chr3:46174605 A/G cg10236987 chr1:228114221 WNT9A 0.59 6.17 0.35 2.61e-9 Celiac disease; CESC cis rs2072732 0.904 rs1138513 chr1:2976816 T/C cg22517653 chr1:2918612 NA -0.41 -5.58 -0.32 5.93e-8 Plateletcrit; CESC cis rs4072980 0.524 rs16824514 chr1:38395947 A/T cg12658694 chr1:38397304 INPP5B 0.72 10.12 0.53 1.5e-20 Coronary artery disease; CESC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg11764359 chr7:65958608 NA 0.96 15.23 0.68 4.78e-38 Aortic root size; CESC cis rs1691799 0.867 rs1168333 chr12:66761377 G/A cg16791601 chr12:66731901 HELB -0.57 -9.25 -0.49 7.88e-18 White blood cell count (basophil); CESC cis rs959260 0.557 rs12943902 chr17:73400627 G/C cg20590849 chr17:73267439 MIF4GD -0.59 -6.55 -0.37 3.01e-10 Systemic lupus erythematosus; CESC cis rs2404602 0.692 rs2137307 chr15:77149020 T/A cg22467129 chr15:76604101 ETFA -0.35 -5.23 -0.31 3.42e-7 Blood metabolite levels; CESC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg19468946 chr17:37922297 IKZF3 0.41 5.26 0.31 3.04e-7 Glomerular filtration rate (creatinine); CESC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg23758822 chr17:41437982 NA 1.02 15.55 0.69 3.45e-39 Menopause (age at onset); CESC trans rs9393777 0.920 rs13195040 chr6:27413924 C/T cg06606381 chr12:133084897 FBRSL1 0.92 7.4 0.41 1.8e-12 Intelligence (multi-trait analysis); CESC cis rs6142102 0.625 rs6141436 chr20:32554571 T/A cg08999081 chr20:33150536 PIGU 0.34 5.1 0.3 6.63e-7 Skin pigmentation; CESC cis rs10465746 0.967 rs1570690 chr1:84377515 G/T cg10977910 chr1:84465055 TTLL7 0.46 6.13 0.35 3.22e-9 Obesity-related traits; CESC cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg01819759 chr13:79234251 RNF219 0.46 6.41 0.37 6.6e-10 Large artery stroke; CESC cis rs9309473 0.948 rs7603647 chr2:73817238 G/A cg20560298 chr2:73613845 ALMS1 -0.54 -7.17 -0.4 7.48e-12 Metabolite levels; CESC trans rs4800995 0.508 rs2126787 chr18:53462608 C/T cg11058942 chr7:1287561 NA 0.42 6.0 0.35 6.54e-9 Cancer; CESC cis rs2414059 0.518 rs56398519 chr15:50773432 A/G cg08437265 chr15:50716283 USP8 -0.48 -6.41 -0.37 6.77e-10 QT interval; CESC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg13206674 chr6:150067644 NUP43 0.44 6.4 0.37 7e-10 Lung cancer; CESC trans rs1545843 0.593 rs4761124 chr12:84789792 A/T cg03015433 chr16:56623111 MT3 -0.34 -6.13 -0.35 3.22e-9 Major depressive disorder; CESC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg06108461 chr20:60628389 TAF4 -0.93 -14.39 -0.66 4.43e-35 Body mass index; CESC trans rs3008870 0.583 rs11208978 chr1:67442210 C/T cg19754094 chr2:74055942 STAMBP -0.62 -6.0 -0.35 6.49e-9 Lymphocyte percentage of white cells; CESC cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg00149659 chr3:10157352 C3orf10 0.69 8.2 0.45 1.02e-14 Alzheimer's disease; CESC cis rs6714710 0.603 rs12104810 chr2:98443658 C/T cg26665480 chr2:98280029 ACTR1B 0.58 8.13 0.45 1.7e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs863345 0.604 rs12041348 chr1:158482042 A/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.74 -0.38 9.86e-11 Pneumococcal bacteremia; CESC cis rs4595586 0.525 rs7977228 chr12:39395060 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs873946 0.586 rs12767391 chr10:134573844 A/G cg27297192 chr10:134578999 INPP5A -0.42 -5.75 -0.33 2.4e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs11792861 0.962 rs72607162 chr9:111793719 T/C cg13535736 chr9:111863775 C9orf5 -0.51 -6.69 -0.38 1.32e-10 Menarche (age at onset); CESC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg17650747 chr5:1873721 NA 0.42 5.79 0.34 2.01e-8 Cardiovascular disease risk factors; CESC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg26939375 chr7:64535504 NA 0.5 6.45 0.37 5.2400000000000005e-10 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23100370 chr2:109336342 RANBP2 0.53 6.16 0.35 2.63e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22395807 chr22:46068466 ATXN10 0.44 6.06 0.35 4.69e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2073300 0.609 rs74273791 chr20:23418067 A/T cg16736954 chr20:23401023 NAPB 0.78 5.78 0.33 2.05e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg26859862 chr16:30389551 SEPT1 -0.49 -6.13 -0.35 3.16e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg06481639 chr22:41940642 POLR3H -0.6 -5.83 -0.34 1.65e-8 Vitiligo; CESC cis rs614226 1.000 rs616157 chr12:120925795 T/C cg01236616 chr12:121019343 POP5 -1.49 -16.4 -0.71 3.39e-42 Type 1 diabetes nephropathy; CESC cis rs2304069 1.000 rs2304069 chr5:149406733 G/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.85 11.23 0.57 3.37e-24 HIV-1 control; CESC cis rs7086627 0.515 rs2125040 chr10:82208422 G/C cg00277334 chr10:82204260 NA -0.91 -15.94 -0.7 1.42e-40 Post bronchodilator FEV1; CESC cis rs6582630 0.533 rs2120464 chr12:38280289 A/C cg26384229 chr12:38710491 ALG10B 0.45 5.8 0.34 1.87e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs1499614 1.000 rs2659903 chr7:66180931 G/A cg13147721 chr7:65941812 NA -0.94 -8.9 -0.48 9.08e-17 Gout; CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg06456125 chr7:65229604 NA 0.38 5.15 0.3 5.09e-7 Calcium levels; CESC trans rs7824557 0.524 rs7835318 chr8:10953874 G/A cg06636001 chr8:8085503 FLJ10661 -0.49 -6.19 -0.36 2.33e-9 Retinal vascular caliber; CESC cis rs7914558 0.966 rs12766205 chr10:104893568 A/G cg04362960 chr10:104952993 NT5C2 0.46 5.92 0.34 9.98e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12822507 0.732 rs4555 chr12:12796872 T/C cg11838227 chr12:12764436 CREBL2 0.41 5.48 0.32 9.95e-8 Systemic lupus erythematosus; CESC cis rs7107174 1.000 rs2512542 chr11:77981780 G/A cg02023728 chr11:77925099 USP35 0.38 5.73 0.33 2.76e-8 Testicular germ cell tumor; CESC trans rs7849270 1.000 rs7021449 chr9:131899312 T/C cg05583848 chr6:35265411 DEF6 -0.44 -6.12 -0.35 3.28e-9 Blood metabolite ratios; CESC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.07e-8 Lung cancer; CESC cis rs6489785 0.643 rs2015462 chr12:121238204 G/C cg02419362 chr12:121203948 SPPL3 0.36 5.87 0.34 1.28e-8 Longevity;Allergic disease (asthma, hay fever or eczema); CESC cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg24308560 chr3:49941425 MST1R 0.63 9.38 0.5 3.2e-18 Intelligence (multi-trait analysis); CESC cis rs1707322 1.000 rs4641257 chr1:46353589 G/A cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1707322 0.686 rs3014251 chr1:46077428 G/C cg05343316 chr1:45956843 TESK2 -0.53 -6.45 -0.37 5.42e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2249625 0.523 rs1969530 chr6:72861276 A/C cg18830697 chr6:72922368 RIMS1 -0.42 -6.22 -0.36 1.92e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs10267417 0.544 rs2072185 chr7:19748700 G/A cg07541023 chr7:19748670 TWISTNB 0.94 10.69 0.55 2.12e-22 Night sleep phenotypes; CESC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg22920501 chr2:26401640 FAM59B -0.91 -10.28 -0.53 4.37e-21 Gut microbiome composition (summer); CESC cis rs3105593 0.933 rs3109882 chr15:50840057 G/A cg08437265 chr15:50716283 USP8 0.44 5.69 0.33 3.44e-8 QT interval; CESC cis rs3026101 0.671 rs3026109 chr17:5284480 C/T cg25236894 chr17:5323110 RPAIN;NUP88 -0.42 -5.53 -0.32 7.63e-8 Body mass index; CESC cis rs6060717 0.536 rs8125966 chr20:34511823 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -6.96 -0.39 2.63e-11 Hip circumference adjusted for BMI; CESC cis rs7084402 0.967 rs1649081 chr10:60292444 G/A cg07615347 chr10:60278583 BICC1 0.6 9.49 0.5 1.45e-18 Refractive error; CESC cis rs116095464 1.000 rs56095714 chr5:311256 C/T cg22496380 chr5:211416 CCDC127 -0.89 -5.63 -0.33 4.52e-8 Breast cancer; CESC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg06634786 chr22:41940651 POLR3H -0.66 -6.61 -0.38 2.11e-10 Vitiligo; CESC cis rs208520 0.690 rs12204512 chr6:66710486 C/T cg07460842 chr6:66804631 NA 0.97 13.04 0.63 2.3e-30 Exhaled nitric oxide output; CESC trans rs1814175 0.817 rs80244685 chr11:49763292 C/A cg03929089 chr4:120376271 NA -0.9 -13.84 -0.65 3.9e-33 Height; CESC cis rs9911578 1.000 rs2009948 chr17:56611920 A/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.53 -0.32 7.63e-8 Intelligence (multi-trait analysis); CESC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg17911788 chr17:44343683 NA -0.38 -5.27 -0.31 2.83e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg10302505 chr8:128748092 MYC -0.5 -6.19 -0.36 2.22e-9 Subjective well-being; CESC cis rs2404602 0.692 rs2304920 chr15:76993867 T/C cg26408565 chr15:76604113 ETFA -0.39 -5.58 -0.32 6.05e-8 Blood metabolite levels; CESC cis rs1008375 1.000 rs3733579 chr4:17694943 A/G cg02297831 chr4:17616191 MED28 0.44 5.38 0.31 1.65e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4689388 0.890 rs9993624 chr4:6286528 C/T cg00701064 chr4:6280414 WFS1 0.76 13.6 0.64 2.55e-32 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg06108461 chr20:60628389 TAF4 -0.92 -14.55 -0.67 1.22e-35 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23307708 chr5:133561976 PPP2CA -0.45 -6.1 -0.35 3.69e-9 Fibrinogen levels; CESC cis rs4595586 0.545 rs1319791 chr12:39372486 G/T cg26384229 chr12:38710491 ALG10B 0.62 8.69 0.47 3.89e-16 Morning vs. evening chronotype; CESC cis rs7107174 1.000 rs2511166 chr11:77964331 T/C cg02023728 chr11:77925099 USP35 0.41 6.06 0.35 4.65e-9 Testicular germ cell tumor; CESC cis rs67460515 0.892 rs2054710 chr3:161090616 C/T cg03342759 chr3:160939853 NMD3 -0.53 -7.52 -0.42 8.32e-13 Parkinson's disease; CESC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg00750074 chr16:89608354 SPG7 -0.42 -6.1 -0.35 3.69e-9 Multiple myeloma (IgH translocation); CESC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg17724175 chr1:150552817 MCL1 0.44 7.24 0.41 4.8e-12 Tonsillectomy; CESC trans rs77688320 0.535 rs7561048 chr2:202253039 G/A cg13208159 chr1:68516518 DIRAS3 0.39 6.01 0.35 6.19e-9 Breast cancer; CESC cis rs1707322 0.964 rs785509 chr1:46527300 G/A cg03146154 chr1:46216737 IPP -0.7 -9.16 -0.49 1.46e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6998277 1.000 rs4281092 chr8:103647956 A/G cg10187029 chr8:103597600 NA -0.45 -5.26 -0.31 3e-7 Migraine; CESC cis rs10089 0.953 rs7713860 chr5:127428789 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.19 0.53 8.58e-21 Ileal carcinoids; CESC cis rs2594989 1.000 rs2606756 chr3:11358181 G/A cg00170343 chr3:11313890 ATG7 0.59 5.25 0.31 3.1e-7 Circulating chemerin levels; CESC cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg19626725 chr5:178986131 RUFY1 0.34 5.05 0.3 8.06e-7 Lung cancer; CESC cis rs66887589 0.616 rs13113885 chr4:120221176 G/C cg09307838 chr4:120376055 NA 0.63 8.38 0.46 3.09e-15 Diastolic blood pressure; CESC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg23283495 chr1:209979779 IRF6 0.53 6.34 0.36 9.65e-10 Cleft lip with or without cleft palate; CESC cis rs7772486 0.625 rs9390355 chr6:146112942 C/T cg05347473 chr6:146136440 FBXO30 -0.53 -7.0 -0.39 2.13e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg02428538 chr16:24856791 SLC5A11 0.6 6.1 0.35 3.72e-9 Intelligence (multi-trait analysis); CESC cis rs763121 0.925 rs4821815 chr22:39105707 G/A cg06022373 chr22:39101656 GTPBP1 0.89 15.89 0.7 2.08e-40 Menopause (age at onset); CESC cis rs6500395 1.000 rs4517800 chr16:48677404 T/A cg04672837 chr16:48644449 N4BP1 0.51 6.31 0.36 1.16e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24847481 chr1:100435557 SLC35A3 0.59 6.39 0.37 7.56e-10 Gut microbiome composition (summer); CESC cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 3.05e-8 Mean platelet volume; CESC cis rs4835473 0.897 rs2089835 chr4:144886280 G/A cg25736465 chr4:144833511 NA 0.41 6.4 0.37 6.85e-10 Immature fraction of reticulocytes; CESC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg09658497 chr7:2847517 GNA12 -0.43 -6.09 -0.35 4.02e-9 Height; CESC cis rs1005277 0.638 rs1005278 chr10:38218748 G/A cg25427524 chr10:38739819 LOC399744 0.6 8.24 0.45 7.78e-15 Extrinsic epigenetic age acceleration; CESC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -10.94 -0.56 3.15e-23 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27279809 chr12:49183212 ADCY6 0.55 6.37 0.36 8.28e-10 Gut microbiome composition (summer); CESC cis rs9457247 0.765 rs9457252 chr6:167433925 A/G cg23791538 chr6:167370224 RNASET2 0.55 7.62 0.42 4.54e-13 Crohn's disease; CESC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg14393609 chr7:65229607 NA -0.41 -5.45 -0.32 1.16e-7 Aortic root size; CESC cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg21918786 chr6:109611834 NA -0.35 -5.03 -0.3 8.9e-7 Reticulocyte fraction of red cells; CESC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg07701084 chr6:150067640 NUP43 0.46 6.45 0.37 5.26e-10 Lung cancer; CESC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg26335602 chr6:28129616 ZNF389 -0.46 -6.41 -0.37 6.57e-10 Depression; CESC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg12963246 chr6:28129442 ZNF389 0.5 6.95 0.39 2.85e-11 Depression; CESC cis rs7044106 0.791 rs747819 chr9:123488441 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.75 10.83 0.55 7.25e-23 Hip circumference adjusted for BMI; CESC cis rs1550582 1.000 rs754234 chr8:135512875 A/G cg17885191 chr8:135476712 NA 0.63 7.33 0.41 2.73e-12 Educational attainment; CESC cis rs13031619 1.000 rs6724730 chr2:3697987 G/C cg19052272 chr2:3704530 ALLC 0.51 6.63 0.38 1.89e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs10447248 0.674 rs6887376 chr5:107896807 G/A cg25075504 chr5:107899390 NA -0.39 -5.91 -0.34 1.05e-8 Adiponectin levels; CESC cis rs8028182 0.636 rs4486847 chr15:75728531 C/G cg20655648 chr15:75932815 IMP3 0.49 6.24 0.36 1.68e-9 Sudden cardiac arrest; CESC cis rs7223966 1.000 rs6504170 chr17:61709168 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.18 0.4 6.94e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6121246 0.909 rs57726761 chr20:30314046 A/G cg13852791 chr20:30311386 BCL2L1 0.82 8.61 0.47 6.59e-16 Mean corpuscular hemoglobin; CESC trans rs61931739 0.890 rs11053018 chr12:34105962 T/G cg26384229 chr12:38710491 ALG10B -0.47 -6.54 -0.37 3.11e-10 Morning vs. evening chronotype; CESC cis rs3092073 0.819 rs3848715 chr20:44564682 G/A cg27529037 chr20:44575021 PCIF1 -0.45 -6.92 -0.39 3.46e-11 Intelligence (multi-trait analysis); CESC cis rs12042938 0.507 rs1765778 chr1:231732356 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.44 -0.46 2.13e-15 Neuranatomic and neurocognitive phenotypes; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg12819747 chr12:112622701 C12orf51 0.43 6.07 0.35 4.49e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7216064 1.000 rs9915108 chr17:65874463 T/C cg12091567 chr17:66097778 LOC651250 -0.81 -9.16 -0.49 1.48e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11723261 0.582 rs6830247 chr4:150683 G/A cg12746427 chr4:53362 ZNF718;ZNF595 0.48 6.12 0.35 3.28e-9 Immune response to smallpox vaccine (IL-6); CESC cis rs11098499 0.826 rs4472123 chr4:120236630 T/A cg09307838 chr4:120376055 NA 0.79 10.57 0.54 5.14e-22 Corneal astigmatism; CESC cis rs11122272 0.735 rs2749723 chr1:231493302 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -7.97 -0.44 4.68e-14 Hemoglobin concentration; CESC cis rs7726839 0.526 rs11960158 chr5:568665 C/T cg09021430 chr5:549028 NA -0.49 -6.71 -0.38 1.19e-10 Obesity-related traits; CESC cis rs9715521 0.900 rs72634623 chr4:59827419 T/C cg11281224 chr4:60001000 NA -0.5 -6.57 -0.37 2.6200000000000003e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs16854884 0.739 rs1898265 chr3:143776096 A/G cg06585982 chr3:143692056 C3orf58 -0.47 -6.15 -0.35 2.77e-9 Economic and political preferences (feminism/equality); CESC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg21724239 chr8:58056113 NA 0.6 5.56 0.32 6.59e-8 Developmental language disorder (linguistic errors); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg13920838 chr9:35095103 PIGO -0.46 -6.12 -0.35 3.44e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9287719 0.967 rs4669599 chr2:10758029 T/C cg00105475 chr2:10696890 NA 0.37 5.4 0.31 1.52e-7 Prostate cancer; CESC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg26338869 chr17:61819248 STRADA 0.69 9.11 0.49 2.04e-17 Prudent dietary pattern; CESC cis rs6032067 0.636 rs6032093 chr20:43912167 A/G cg10761708 chr20:43804764 PI3 0.41 5.32 0.31 2.25e-7 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01975877 chr1:9324232 H6PD -0.61 -7.37 -0.41 2.2e-12 Gut microbiome composition (summer); CESC cis rs4595586 0.545 rs4438082 chr12:39363870 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC cis rs3793917 0.901 rs36212733 chr10:124215211 T/C cg24884230 chr10:124216658 ARMS2 0.31 5.15 0.3 5.08e-7 Age-related macular degeneration; CESC cis rs2354432 0.607 rs6689243 chr1:146710559 A/T cg25205988 chr1:146714368 CHD1L -1.02 -8.75 -0.47 2.49e-16 Mitochondrial DNA levels; CESC cis rs1577917 0.958 rs10944144 chr6:86537755 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.51 -6.61 -0.38 2.11e-10 Response to antipsychotic treatment; CESC trans rs7937682 0.961 rs17113227 chr11:111620491 A/G cg18187862 chr3:45730750 SACM1L 0.51 6.16 0.35 2.64e-9 Primary sclerosing cholangitis; CESC cis rs7927592 0.763 rs10896327 chr11:68235275 G/C cg16797656 chr11:68205561 LRP5 0.48 7.29 0.41 3.63e-12 Total body bone mineral density; CESC trans rs3942852 0.568 rs4412719 chr11:48101660 T/A cg15704280 chr7:45808275 SEPT13 -0.72 -9.41 -0.5 2.58e-18 Acute lymphoblastic leukemia (childhood); CESC cis rs7520050 0.902 rs7514192 chr1:46248977 A/G cg03146154 chr1:46216737 IPP -0.49 -6.35 -0.36 9.45e-10 Red blood cell count;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13474011 chr10:49515374 NA -0.59 -6.35 -0.36 9.25e-10 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs10036253 chr5:238519 A/C cg22496380 chr5:211416 CCDC127 -0.75 -8.78 -0.47 2.13e-16 Breast cancer; CESC cis rs7631605 0.743 rs9839933 chr3:37195162 G/T cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.12 -0.3 6e-7 Cerebrospinal P-tau181p levels; CESC cis rs11958404 0.932 rs59246968 chr5:157418180 T/C cg05962755 chr5:157440814 NA 0.58 6.53 0.37 3.31e-10 IgG glycosylation; CESC cis rs1568889 1.000 rs12808162 chr11:28067027 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.85 0.55 5.96e-23 Bipolar disorder; CESC cis rs7918232 0.941 rs7907988 chr10:27444344 T/G cg14240646 chr10:27532245 ACBD5 -0.72 -6.87 -0.39 4.7e-11 Breast cancer; CESC cis rs4253772 0.591 rs6007727 chr22:46650959 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.18 0.45 1.16e-14 LDL cholesterol;Cholesterol, total; CESC cis rs9914544 0.564 rs1859083 chr17:18843306 C/T cg26378065 chr17:18585709 ZNF286B -0.49 -7.06 -0.4 1.47e-11 Educational attainment (years of education); CESC cis rs4704187 0.687 rs10942729 chr5:74364300 C/T cg03227963 chr5:74354835 NA 0.31 5.74 0.33 2.58e-8 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13803048 chr20:10414896 C20orf94;MKKS 0.6 6.75 0.38 9.32e-11 Gut microbiome composition (summer); CESC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.9 0.39 3.73e-11 Electroencephalogram traits; CESC cis rs7903847 0.667 rs3818787 chr10:99145179 T/C cg20016023 chr10:99160130 RRP12 -0.29 -5.09 -0.3 6.83e-7 Granulocyte percentage of myeloid white cells; CESC cis rs473651 0.692 rs579511 chr2:239334914 C/G cg21699342 chr2:239360505 ASB1 0.53 8.7 0.47 3.6e-16 Multiple system atrophy; CESC cis rs1707322 0.682 rs12037459 chr1:46094959 T/G cg05343316 chr1:45956843 TESK2 0.53 6.54 0.37 3.2e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9902453 0.817 rs2617881 chr17:28063275 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.74 -9.54 -0.51 9.82e-19 Coffee consumption (cups per day); CESC cis rs1256061 0.624 rs1256046 chr14:64729356 A/C cg21174375 chr14:64681225 SYNE2 0.51 6.82 0.39 6.15e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg04944784 chr2:26401820 FAM59B 0.96 10.53 0.54 6.93e-22 Gut microbiome composition (summer); CESC cis rs883565 0.916 rs12636980 chr3:39124132 C/T cg26331595 chr3:39149181 GORASP1;TTC21A -0.45 -5.81 -0.34 1.75e-8 Handedness; CESC cis rs10870270 1.000 rs11146324 chr10:133767445 A/C cg08754478 chr10:133766260 PPP2R2D -0.58 -7.52 -0.42 8.4e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg20307385 chr11:47447363 PSMC3 -0.59 -7.05 -0.4 1.56e-11 Subjective well-being; CESC cis rs887829 0.569 rs6431628 chr2:234647478 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.5 -6.59 -0.38 2.36e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs7927771 0.507 rs7111606 chr11:47787538 G/A cg18512352 chr11:47633146 NA 0.34 5.24 0.31 3.22e-7 Subjective well-being; CESC cis rs2243480 1.000 rs34703416 chr7:65300642 A/G cg12463550 chr7:65579703 CRCP 0.67 5.5 0.32 9.08e-8 Diabetic kidney disease; CESC cis rs7772486 0.875 rs6570736 chr6:146388320 C/T cg23711669 chr6:146136114 FBXO30 0.86 12.94 0.62 5.03e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs12541635 0.677 rs2029879 chr8:107024695 T/A cg10147462 chr8:107024639 NA 0.48 7.39 0.41 1.94e-12 Age of smoking initiation; CESC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.05 -0.3 8.06e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs2354432 1.000 rs6680778 chr1:146747153 T/C cg25205988 chr1:146714368 CHD1L 1.11 16.73 0.72 2.26e-43 Mitochondrial DNA levels; CESC cis rs12477438 0.520 rs2969379 chr2:99776686 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.08 0.68 1.62e-37 Chronic sinus infection; CESC cis rs2730245 0.851 rs2657333 chr7:158728743 G/A cg15303052 chr7:158526867 ESYT2 0.42 5.09 0.3 6.68e-7 Height; CESC trans rs561341 1.000 rs484175 chr17:30309041 G/A cg20587970 chr11:113659929 NA -1.41 -18.23 -0.75 1.08e-48 Hip circumference adjusted for BMI; CESC cis rs6120849 0.754 rs7268266 chr20:33581889 T/C cg24642439 chr20:33292090 TP53INP2 0.67 6.62 0.38 1.94e-10 Protein C levels; CESC cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg20476274 chr7:133979776 SLC35B4 0.68 9.93 0.52 5.8e-20 Mean platelet volume; CESC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg04267008 chr7:1944627 MAD1L1 0.61 7.59 0.42 5.5e-13 Bipolar disorder and schizophrenia; CESC cis rs1211375 0.628 rs3859141 chr16:245079 T/C cg00126636 chr16:237282 NA -0.42 -6.34 -0.36 9.62e-10 Hematology traits;Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs6500395 1.000 rs7202551 chr16:48728984 A/G cg04672837 chr16:48644449 N4BP1 -0.49 -5.94 -0.34 8.78e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs5498 0.809 rs2228615 chr19:10403368 G/A cg21994045 chr19:10403936 ICAM5 0.45 6.36 0.36 8.75e-10 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs7044106 0.708 rs920745 chr9:123429943 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.83 0.34 1.58e-8 Hip circumference adjusted for BMI; CESC cis rs829880 0.570 rs4488248 chr12:98853688 G/C cg25150519 chr12:98850993 NA 0.84 11.16 0.57 5.76e-24 Colonoscopy-negative controls vs population controls; CESC cis rs5753618 0.504 rs9609303 chr22:31896309 C/T cg02404636 chr22:31891804 SFI1 0.42 5.64 0.33 4.35e-8 Colorectal cancer; CESC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg06873352 chr17:61820015 STRADA 0.47 7.03 0.4 1.74e-11 Height; CESC cis rs300703 0.816 rs449725 chr2:202993 C/G cg21211680 chr2:198530 NA -0.78 -7.3 -0.41 3.3e-12 Blood protein levels; CESC cis rs9487051 0.621 rs351747 chr6:109531855 G/T cg01475377 chr6:109611718 NA -0.39 -5.16 -0.3 4.76e-7 Reticulocyte fraction of red cells; CESC cis rs1670533 0.932 rs610218 chr4:1080083 C/G cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.88e-7 Recombination rate (females); CESC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg16606324 chr3:10149918 C3orf24 0.46 5.06 0.3 8.03e-7 Alzheimer's disease; CESC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg04756594 chr16:24857601 SLC5A11 -0.45 -5.52 -0.32 8.21e-8 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03395546 chr19:41222599 ADCK4;ITPKC 0.55 6.85 0.39 5.15e-11 Gut microbiome composition (summer); CESC cis rs2415984 0.579 rs1389608 chr14:46957777 C/A cg14871534 chr14:47121158 RPL10L -0.35 -5.22 -0.31 3.62e-7 Number of children ever born; CESC cis rs1953600 0.870 rs1049550 chr10:81926702 G/A cg00277334 chr10:82204260 NA -0.42 -5.89 -0.34 1.17e-8 Sarcoidosis; CESC cis rs66530629 0.874 rs4648876 chr1:25097392 A/G cg22509179 chr1:25234806 RUNX3 -0.47 -6.08 -0.35 4.08e-9 Plateletcrit; CESC cis rs12500824 0.564 rs57987880 chr4:77318460 G/A cg20311846 chr4:77356250 SHROOM3 0.38 7.46 0.42 1.24e-12 Coronary artery disease; CESC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg17971929 chr21:40555470 PSMG1 -0.87 -12.79 -0.62 1.75e-29 Cognitive function; CESC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg09359103 chr1:154839909 KCNN3 -0.65 -12.31 -0.6 7.76e-28 Prostate cancer; CESC cis rs5747327 0.874 rs715532 chr22:18159946 A/G cg19898043 chr22:18121309 BCL2L13 -0.41 -5.26 -0.31 2.99e-7 Myeloid white cell count;Granulocyte count; CESC cis rs367943 1.000 rs348960 chr5:112820651 C/A cg12552261 chr5:112820674 MCC 0.64 8.05 0.44 2.83e-14 Type 2 diabetes; CESC cis rs10242455 0.717 rs776745 chr7:99291337 T/G cg07715041 chr7:99302981 CYP3A7 0.44 5.56 0.32 6.73e-8 Blood metabolite levels; CESC cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg13628971 chr7:2884303 GNA12 0.4 5.5 0.32 8.77e-8 Height; CESC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg06494592 chr3:125709126 NA -0.44 -5.08 -0.3 7.09e-7 Blood pressure (smoking interaction); CESC cis rs7666738 0.716 rs1426660 chr4:98876792 T/A cg03467027 chr4:99064603 C4orf37 0.42 5.16 0.3 4.73e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04377525 chr19:2977344 TLE6 0.57 6.51 0.37 3.72e-10 Gut microbiome composition (summer); CESC cis rs2230307 0.572 rs621212 chr1:100559281 T/C cg24955406 chr1:100503596 HIAT1 0.53 5.39 0.31 1.56e-7 Carotid intima media thickness; CESC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg05564831 chr3:52568323 NT5DC2 0.44 6.76 0.38 8.84e-11 Bipolar disorder; CESC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg01988459 chr11:68622903 NA -0.45 -6.36 -0.36 8.85e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2361718 0.564 rs2304844 chr17:78084507 G/C cg21238619 chr17:78079768 GAA -0.44 -6.79 -0.39 7.15e-11 Yeast infection; CESC cis rs6570726 0.764 rs9403726 chr6:145901686 G/T cg23711669 chr6:146136114 FBXO30 0.9 13.47 0.64 7.7e-32 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13973351 chr11:60928923 VPS37C 0.6 6.62 0.38 1.99e-10 Gut microbiome composition (summer); CESC trans rs208520 0.690 rs12202913 chr6:66734198 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.27 0.6 1.08e-27 Exhaled nitric oxide output; CESC cis rs7208859 0.673 rs73263981 chr17:28920502 A/G cg14008862 chr17:28927542 LRRC37B2 0.68 6.0 0.35 6.32e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13580096 chr8:66546317 ARMC1 -0.48 -6.06 -0.35 4.61e-9 Ulcerative colitis; CESC cis rs1499972 0.941 rs6769144 chr3:117624517 C/T cg07612923 chr3:117604196 NA 0.88 7.62 0.42 4.47e-13 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01071279 chr10:70939636 SUPV3L1 0.46 6.31 0.36 1.17e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg00149659 chr3:10157352 C3orf10 0.72 9.27 0.49 6.61e-18 Alzheimer's disease; CESC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg23708337 chr7:1209742 NA 0.53 5.24 0.31 3.28e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7824557 0.603 rs11250130 chr8:11214455 C/T cg21775007 chr8:11205619 TDH -0.56 -8.6 -0.47 7.2e-16 Retinal vascular caliber; CESC cis rs7674212 0.570 rs12501621 chr4:104095505 T/G cg16532752 chr4:104119610 CENPE -0.44 -5.97 -0.34 7.58e-9 Type 2 diabetes; CESC cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg03433033 chr1:76189801 ACADM -0.62 -6.52 -0.37 3.45e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg18240062 chr17:79603768 NPLOC4 -0.54 -7.18 -0.4 7.17e-12 Eye color traits; CESC cis rs9790314 1.000 rs336548 chr3:161058412 T/C cg04691961 chr3:161091175 C3orf57 -0.4 -5.11 -0.3 6.05e-7 Morning vs. evening chronotype; CESC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 8.47 0.46 1.68e-15 Platelet count; CESC cis rs7584330 0.652 rs7607231 chr2:238372896 T/C cg14458575 chr2:238380390 NA 0.6 8.41 0.46 2.49e-15 Prostate cancer; CESC cis rs559928 0.557 rs7122408 chr11:63898826 G/T cg18225595 chr11:63971243 STIP1 0.66 5.64 0.33 4.29e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs863345 0.604 rs1578761 chr1:158497572 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.78e-11 Pneumococcal bacteremia; CESC cis rs9902453 0.838 rs7217638 chr17:28336772 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.83 -0.43 1.15e-13 Coffee consumption (cups per day); CESC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg21770322 chr7:97807741 LMTK2 0.57 8.65 0.47 5.18e-16 Prostate cancer (SNP x SNP interaction); CESC trans rs208520 1.000 rs12194996 chr6:66973366 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 7.86 0.43 9.45e-14 Exhaled nitric oxide output; CESC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg25072359 chr17:41440525 NA 0.43 5.83 0.34 1.61e-8 Menopause (age at onset); CESC cis rs12142240 0.698 rs68012736 chr1:46839510 A/G cg00530320 chr1:46809349 NSUN4 0.6 7.92 0.44 6.39e-14 Menopause (age at onset); CESC cis rs7267979 1.000 rs4815407 chr20:25341478 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -16.46 -0.71 2.08e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs2070488 1.000 rs1841777 chr3:38484819 T/C cg24069376 chr3:38537580 EXOG 0.48 8.72 0.47 3.05e-16 Electrocardiographic conduction measures; CESC cis rs3815700 1.000 rs7247420 chr19:33096786 G/A cg24916020 chr19:33096688 ANKRD27 0.58 5.72 0.33 2.82e-8 Eosinophilic esophagitis; CESC cis rs80282103 0.618 rs17155886 chr10:1145182 A/G cg08668510 chr10:1095578 IDI1 0.75 6.25 0.36 1.65e-9 Glomerular filtration rate (creatinine); CESC cis rs6504663 0.525 rs557 chr17:48563234 C/T cg03611598 chr17:48586076 MYCBPAP 0.53 6.17 0.35 2.54e-9 Visceral fat; CESC cis rs12478296 1.000 rs11899408 chr2:243014630 A/G cg06360820 chr2:242988706 NA -0.76 -8.58 -0.47 8.05e-16 Obesity-related traits; CESC cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg02487422 chr3:49467188 NICN1 0.39 5.03 0.3 9.01e-7 Parkinson's disease; CESC cis rs9611565 0.546 rs5758431 chr22:42109917 A/G cg06481639 chr22:41940642 POLR3H 0.64 6.55 0.37 2.94e-10 Vitiligo; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg01140101 chr1:202113040 ARL8A 0.46 6.02 0.35 5.77e-9 Weight; CESC cis rs1008375 0.966 rs3775927 chr4:17599894 G/T cg15017067 chr4:17643749 FAM184B 0.36 5.11 0.3 6.19e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg08968635 chr6:28129556 ZNF389 0.41 5.5 0.32 9.04e-8 Depression; CESC cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg01579765 chr21:45077557 HSF2BP 0.57 9.49 0.5 1.36e-18 Mean corpuscular volume; CESC cis rs9929218 1.000 rs12599517 chr16:68814590 T/C cg02972257 chr16:68554789 NA 0.44 5.23 0.31 3.4e-7 Colorectal cancer; CESC cis rs2304069 0.644 rs216131 chr5:149431223 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.68 7.76 0.43 1.86e-13 HIV-1 control; CESC cis rs2011503 0.941 rs55765017 chr19:19368264 G/A cg11584989 chr19:19387371 SF4 0.63 7.52 0.42 8.34e-13 Bipolar disorder; CESC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.77 -9.67 -0.51 3.84e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7772486 0.790 rs2265919 chr6:146221753 A/G cg23711669 chr6:146136114 FBXO30 0.92 13.36 0.63 1.78e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs7647973 0.626 rs2131108 chr3:49665390 C/T cg07636037 chr3:49044803 WDR6 0.47 5.68 0.33 3.62e-8 Menarche (age at onset); CESC cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg07636037 chr3:49044803 WDR6 1.06 18.4 0.75 2.81e-49 Parkinson's disease; CESC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg03188948 chr7:1209495 NA 0.73 7.05 0.4 1.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10752881 1.000 rs4593781 chr1:182984983 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.79e-31 Colorectal cancer; CESC cis rs7208859 0.623 rs11658945 chr17:29122509 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9303401 0.614 rs3803752 chr17:56540267 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.94 10.69 0.55 2.01e-22 Cognitive test performance; CESC cis rs6957923 0.655 rs10232644 chr7:23591920 A/G cg20265043 chr7:23510089 IGF2BP3 0.41 5.06 0.3 7.93e-7 Height; CESC cis rs9549260 0.755 rs9549236 chr13:41147158 C/T cg21288729 chr13:41239152 FOXO1 -0.44 -5.48 -0.32 9.73e-8 Red blood cell count; CESC cis rs1008375 0.931 rs6449309 chr4:17573208 C/T cg27347728 chr4:17578864 LAP3 0.49 5.6 0.33 5.36e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1124376 1.000 rs6774367 chr3:20163077 G/A cg05072819 chr3:20081367 KAT2B 0.47 5.37 0.31 1.71e-7 Bipolar disorder and schizophrenia; CESC cis rs8141529 0.504 rs6005915 chr22:29233262 A/G cg15103426 chr22:29168792 CCDC117 0.57 6.87 0.39 4.6e-11 Lymphocyte counts; CESC cis rs1707322 0.717 rs2253862 chr1:46081960 C/T cg03146154 chr1:46216737 IPP -0.8 -11.01 -0.56 1.87e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2294693 0.891 rs9369256 chr6:40998344 G/C cg14769373 chr6:40998127 UNC5CL -0.48 -6.64 -0.38 1.73e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.55 0.46 1.02e-15 Menopause (age at onset); CESC cis rs7116495 1.000 rs6592448 chr11:71670044 C/T cg26138937 chr11:71823887 C11orf51 0.78 6.77 0.38 8.24e-11 Severe influenza A (H1N1) infection; CESC cis rs72945132 0.882 rs67529561 chr11:70162055 G/T cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs9487051 0.768 rs351729 chr6:109511668 T/C cg01475377 chr6:109611718 NA 0.37 5.48 0.32 9.72e-8 Reticulocyte fraction of red cells; CESC cis rs3824867 0.920 rs4282946 chr11:47456202 G/A cg20307385 chr11:47447363 PSMC3 0.5 6.09 0.35 3.87e-9 Mean corpuscular hemoglobin; CESC cis rs9916302 0.904 rs11654018 chr17:37703740 C/T cg15445000 chr17:37608096 MED1 -0.39 -6.31 -0.36 1.16e-9 Glomerular filtration rate (creatinine); CESC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg03709012 chr19:19516395 GATAD2A 1.0 15.01 0.68 2.76e-37 Tonsillectomy; CESC cis rs13256369 0.802 rs34762800 chr8:8559294 G/A cg18904891 chr8:8559673 CLDN23 0.72 8.02 0.44 3.5e-14 Obesity-related traits; CESC cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg07636037 chr3:49044803 WDR6 1.03 18.76 0.76 1.49e-50 Parkinson's disease; CESC cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg21573476 chr21:45109991 RRP1B -0.5 -6.92 -0.39 3.44e-11 Mean corpuscular volume; CESC cis rs7219021 0.886 rs9915337 chr17:46857421 T/A cg16584676 chr17:46985605 UBE2Z -0.56 -6.32 -0.36 1.08e-9 Schizophrenia or bipolar disorder; CESC cis rs9911578 0.817 rs304264 chr17:56749628 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.19 -0.4 6.72e-12 Intelligence (multi-trait analysis); CESC cis rs4888262 0.526 rs6564142 chr16:74590047 T/C cg01733217 chr16:74700730 RFWD3 0.81 11.35 0.57 1.4e-24 Testicular germ cell tumor; CESC cis rs1878931 0.582 rs10048083 chr16:3417465 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.75 9.58 0.51 7.13e-19 Body mass index (adult); CESC cis rs1568889 1.000 rs61889027 chr11:28281908 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.71 8.28 0.45 6.08e-15 Bipolar disorder; CESC cis rs4604732 0.578 rs112449432 chr1:247624180 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.4 0.31 1.5e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2274273 0.624 rs7152390 chr14:55811701 C/T cg04306507 chr14:55594613 LGALS3 0.29 5.13 0.3 5.66e-7 Protein biomarker; CESC cis rs8020095 0.528 rs7147570 chr14:67391903 T/C cg19548862 chr14:67692701 FAM71D -0.5 -6.1 -0.35 3.83e-9 Depression (quantitative trait); CESC cis rs1538970 0.924 rs11211108 chr1:45891152 C/T cg05343316 chr1:45956843 TESK2 0.89 12.41 0.61 3.59e-28 Platelet count; CESC cis rs9611565 0.512 rs132784 chr22:42052363 G/A cg06634786 chr22:41940651 POLR3H 0.59 5.93 0.34 9.66e-9 Vitiligo; CESC cis rs887829 0.569 rs4663967 chr2:234653184 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.49 -6.37 -0.36 8.39e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs7590368 0.600 rs56143168 chr2:10916233 A/G cg15705551 chr2:10952987 PDIA6 0.58 5.23 0.31 3.52e-7 Educational attainment (years of education); CESC trans rs61931739 0.500 rs11053166 chr12:34385898 A/C cg13010199 chr12:38710504 ALG10B -0.55 -6.69 -0.38 1.33e-10 Morning vs. evening chronotype; CESC cis rs9905704 0.589 rs2632509 chr17:56487887 C/T cg12560992 chr17:57184187 TRIM37 -0.61 -5.54 -0.32 7.25e-8 Testicular germ cell tumor; CESC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -12.98 -0.62 3.88e-30 Developmental language disorder (linguistic errors); CESC cis rs10411262 0.506 rs6509290 chr19:47183840 T/C cg13467550 chr19:47212573 PRKD2 0.34 5.05 0.3 8.15e-7 Tonsillectomy; CESC cis rs7116495 0.609 rs2155145 chr11:71719619 G/T cg26138937 chr11:71823887 C11orf51 -1.31 -8.57 -0.47 8.98e-16 Severe influenza A (H1N1) infection; CESC cis rs372883 0.613 rs1153290 chr21:30687404 G/T cg24692254 chr21:30365293 RNF160 -0.49 -6.24 -0.36 1.69e-9 Pancreatic cancer; CESC cis rs62229266 0.804 rs2835231 chr21:37390598 C/T cg12218747 chr21:37451666 NA -0.44 -6.27 -0.36 1.46e-9 Mitral valve prolapse; CESC cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 5.92e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7264396 0.790 rs2425160 chr20:34425968 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.61 7.32 0.41 2.9e-12 Total cholesterol levels; CESC cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg20503657 chr10:835505 NA 0.7 7.85 0.43 1.04e-13 Eosinophil percentage of granulocytes; CESC cis rs7085104 0.632 rs3781287 chr10:104595420 A/C cg15744005 chr10:104629667 AS3MT -0.32 -5.08 -0.3 7e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs1707322 1.000 rs4074225 chr1:46392364 G/C cg06784218 chr1:46089804 CCDC17 0.36 6.01 0.35 5.95e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg20307385 chr11:47447363 PSMC3 -0.5 -6.09 -0.35 4.06e-9 Subjective well-being; CESC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg03467027 chr4:99064603 C4orf37 0.48 6.15 0.35 2.83e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3026101 0.697 rs2107152 chr17:5297350 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.17 -0.3 4.54e-7 Electroencephalogram traits; CESC cis rs12541635 0.677 rs6997487 chr8:106965511 A/C cg10147462 chr8:107024639 NA 0.43 6.28 0.36 1.42e-9 Age of smoking initiation; CESC cis rs10870270 0.956 rs7915388 chr10:133734972 G/A cg17892150 chr10:133769511 PPP2R2D -0.86 -12.69 -0.61 3.83e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs11190604 1.000 rs11190596 chr10:102293238 C/G cg07080220 chr10:102295463 HIF1AN 0.69 6.37 0.36 8.1e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs73110464 0.562 rs2363634 chr12:53354683 A/G cg14581129 chr12:53358946 NA -0.59 -7.85 -0.43 1.01e-13 Cancer (pleiotropy); CESC cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.21 0.31 3.73e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7851660 0.809 rs7866436 chr9:100650096 G/A cg13688889 chr9:100608707 NA -0.6 -8.42 -0.46 2.33e-15 Strep throat; CESC cis rs74181299 0.684 rs9797989 chr2:65336529 T/C cg05010058 chr2:65284262 CEP68 -0.32 -5.14 -0.3 5.37e-7 Pulse pressure; CESC cis rs7264396 0.690 rs2425183 chr20:34450621 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.41 0.41 1.67e-12 Total cholesterol levels; CESC cis rs1018836 0.892 rs10105142 chr8:91547420 C/T cg16814680 chr8:91681699 NA -0.61 -8.85 -0.48 1.32e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs35110281 0.712 rs8133523 chr21:45062403 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 7.29 0.41 3.61e-12 Mean corpuscular volume; CESC cis rs73206853 0.764 rs7299230 chr12:110618512 A/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.62 0.33 4.79e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs1023500 0.573 rs4822088 chr22:42470589 G/C cg15557168 chr22:42548783 NA -0.44 -6.19 -0.36 2.31e-9 Schizophrenia; CESC cis rs2299587 0.554 rs2073567 chr8:17754034 G/A cg08627089 chr8:17753878 FGL1 -0.39 -5.63 -0.33 4.49e-8 Economic and political preferences; CESC cis rs6665290 0.839 rs6699400 chr1:227190497 A/G cg10327440 chr1:227177885 CDC42BPA -1.23 -34.46 -0.9 6.86e-100 Myeloid white cell count; CESC cis rs67478160 0.619 rs12886363 chr14:104273786 T/C cg08213375 chr14:104286397 PPP1R13B 0.52 9.81 0.52 1.44e-19 Schizophrenia; CESC cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg05340658 chr4:99064831 C4orf37 0.73 10.38 0.54 2.13e-21 Colonoscopy-negative controls vs population controls; CESC cis rs6570726 0.791 rs414297 chr6:145887556 C/T cg23711669 chr6:146136114 FBXO30 0.92 13.93 0.65 1.83e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs3091242 0.933 rs1534954 chr1:25761924 A/T cg27572855 chr1:25598939 RHD 0.47 7.77 0.43 1.77e-13 Erythrocyte sedimentation rate; CESC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg05313129 chr8:58192883 C8orf71 -0.53 -6.08 -0.35 4.23e-9 Developmental language disorder (linguistic errors); CESC cis rs10465746 0.780 rs1570691 chr1:84370393 A/C cg10977910 chr1:84465055 TTLL7 0.51 7.01 0.4 2.02e-11 Obesity-related traits; CESC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17977795 chr5:55290997 IL6ST -0.46 -6.28 -0.36 1.38e-9 Fibrinogen levels; CESC cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg03433033 chr1:76189801 ACADM -0.63 -6.38 -0.36 8.01e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9487051 0.714 rs6930733 chr6:109631587 T/C cg12927641 chr6:109611667 NA -0.37 -5.51 -0.32 8.68e-8 Reticulocyte fraction of red cells; CESC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.73 7.49 0.42 1.01e-12 Platelet count; CESC cis rs36051895 0.632 rs10974987 chr9:5169302 G/T cg02405213 chr9:5042618 JAK2 -0.45 -5.34 -0.31 1.95e-7 Pediatric autoimmune diseases; CESC cis rs9303401 0.659 rs2072316 chr17:56604813 G/T cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.54e-29 Cognitive test performance; CESC cis rs11864453 0.826 rs6499560 chr16:72147666 G/T cg01557791 chr16:72042693 DHODH 0.52 6.87 0.39 4.53e-11 Fibrinogen levels; CESC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs6546537 0.824 rs13011186 chr2:69778558 C/T cg10773587 chr2:69614142 GFPT1 -0.66 -8.33 -0.46 4.28e-15 Serum thyroid-stimulating hormone levels; CESC cis rs17376456 0.877 rs12153501 chr5:93360866 T/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.2 0.3 3.98e-7 Diabetic retinopathy; CESC cis rs910316 0.763 rs12588981 chr14:75460561 A/G cg11812906 chr14:75593930 NEK9 0.78 12.12 0.6 3.38e-27 Height; CESC cis rs734999 0.545 rs10752748 chr1:2544640 G/A cg18854424 chr1:2615690 NA 0.29 5.56 0.32 6.62e-8 Ulcerative colitis; CESC cis rs3806843 0.518 rs2569191 chr5:140013903 C/T cg26395211 chr5:140044315 WDR55 0.4 5.05 0.3 8.11e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2228479 0.867 rs62052185 chr16:89969254 C/T cg00800038 chr16:89945340 TCF25 -0.87 -7.53 -0.42 7.78e-13 Skin colour saturation; CESC cis rs2742234 0.541 rs1059484 chr10:43679800 T/G cg07801480 chr10:43725741 RASGEF1A 0.41 5.29 0.31 2.56e-7 Hirschsprung disease; CESC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg03452623 chr4:187889614 NA -0.88 -16.16 -0.7 2.39e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs2952156 0.883 rs1495100 chr17:37832279 C/T cg00129232 chr17:37814104 STARD3 -0.78 -11.13 -0.56 7.12e-24 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07049977 chr2:37458536 CEBPZ;C2orf56 0.57 6.14 0.35 2.96e-9 Gut microbiome composition (summer); CESC cis rs9487051 0.768 rs1269172 chr6:109522080 G/C cg01475377 chr6:109611718 NA -0.46 -6.93 -0.39 3.18e-11 Reticulocyte fraction of red cells; CESC cis rs4862307 0.836 rs11132220 chr4:184997247 A/T cg06737308 chr4:185021514 ENPP6 -0.42 -5.76 -0.33 2.34e-8 Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs791888 0.723 rs1980648 chr10:89422369 T/C cg13926569 chr10:89418898 PAPSS2 0.52 7.22 0.41 5.67e-12 Magnesium levels; CESC cis rs793571 0.566 rs610877 chr15:59103328 C/A cg05156742 chr15:59063176 FAM63B 0.58 7.62 0.42 4.54e-13 Schizophrenia; CESC cis rs854765 0.693 rs8080061 chr17:17776389 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.54 -7.8 -0.43 1.39e-13 Total body bone mineral density; CESC cis rs208520 0.586 rs208442 chr6:66900618 T/A cg07460842 chr6:66804631 NA -0.69 -8.81 -0.48 1.69e-16 Exhaled nitric oxide output; CESC cis rs4523957 0.583 rs2641444 chr17:2037402 T/C cg16513277 chr17:2031491 SMG6 -0.79 -11.73 -0.58 6.95e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg08470875 chr2:26401718 FAM59B -0.48 -5.19 -0.3 4.26e-7 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg00149659 chr3:10157352 C3orf10 0.73 9.0 0.48 4.43e-17 Alzheimer's disease; CESC cis rs116095464 0.558 rs6555055 chr5:226160 A/C cg20965017 chr5:231967 SDHA -0.44 -5.04 -0.3 8.77e-7 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00387170 chr6:41514002 FOXP4 -0.47 -6.44 -0.37 5.7e-10 Gut microbiota (bacterial taxa); CESC cis rs10208940 0.920 rs11894861 chr2:68706723 C/G cg12452813 chr2:68675892 NA 0.52 5.25 0.31 3.09e-7 Urate levels in lean individuals; CESC cis rs7524258 0.903 rs4908609 chr1:7292910 G/A cg07173049 chr1:7289937 CAMTA1 0.47 7.14 0.4 9e-12 Tourette's syndrome or obsessive-compulsive disorder; CESC trans rs3885907 0.542 rs4254166 chr13:31322949 T/C cg22352122 chr11:453757 PTDSS2 -0.38 -6.06 -0.35 4.63e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU); CESC cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg01579765 chr21:45077557 HSF2BP -0.57 -9.46 -0.5 1.73e-18 Mean corpuscular volume; CESC cis rs17039065 1.000 rs17039068 chr4:109385975 C/A cg16022748 chr4:109541635 LOC285456;RPL34 0.61 5.28 0.31 2.68e-7 Gut microbiome composition (summer); CESC cis rs826838 1.000 rs11168218 chr12:38884466 A/G cg26384229 chr12:38710491 ALG10B 0.83 14.68 0.67 4e-36 Heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.4.3470285F chr4:187530505 FAT1 -0.55 -6.66 -0.38 1.59e-10 Gut microbiome composition (summer); CESC cis rs3008870 0.755 rs6657065 chr1:67384639 T/G cg02640540 chr1:67518911 SLC35D1 0.45 5.38 0.31 1.61e-7 Lymphocyte percentage of white cells; CESC cis rs6088580 0.609 rs2378205 chr20:33110803 C/G cg08999081 chr20:33150536 PIGU 0.65 11.26 0.57 2.65e-24 Glomerular filtration rate (creatinine); CESC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg01763666 chr17:80159506 CCDC57 -0.37 -5.09 -0.3 6.83e-7 Life satisfaction; CESC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.65 8.46 0.46 1.77e-15 Tonsillectomy; CESC cis rs9309473 0.950 rs6745480 chr2:73840055 C/T cg20560298 chr2:73613845 ALMS1 -0.43 -5.68 -0.33 3.53e-8 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22622495 chr1:91966418 CDC7 0.59 7.18 0.4 6.99e-12 Gut microbiome composition (summer); CESC cis rs11122272 0.735 rs2790877 chr1:231535427 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.08 0.35 4.14e-9 Hemoglobin concentration; CESC cis rs6570726 0.791 rs4332001 chr6:145934841 T/C cg23711669 chr6:146136114 FBXO30 0.87 12.74 0.62 2.52e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs1797885 0.651 rs1552484 chr3:12580246 C/G cg26432171 chr3:12704882 RAF1 -0.48 -6.28 -0.36 1.37e-9 Immature fraction of reticulocytes; CESC cis rs6942756 0.758 rs13226649 chr7:128977598 C/T cg02491457 chr7:128862824 NA -0.62 -8.81 -0.48 1.67e-16 White matter hyperintensity burden; CESC cis rs4664308 1.000 rs6759924 chr2:160912747 G/A cg03641300 chr2:160917029 PLA2R1 -0.68 -9.96 -0.52 4.8e-20 Idiopathic membranous nephropathy; CESC cis rs863345 0.933 rs11265020 chr1:158511642 T/C cg12129480 chr1:158549410 OR10X1 -0.32 -6.47 -0.37 4.61e-10 Pneumococcal bacteremia; CESC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg06453172 chr10:134556979 INPP5A -0.42 -5.32 -0.31 2.19e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs116095464 0.614 rs62344292 chr5:244630 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.63 -0.47 5.66e-16 Breast cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10633746 chr17:18164442 SMCR7 0.45 6.28 0.36 1.38e-9 Systemic lupus erythematosus; CESC cis rs61931739 0.817 rs2203086 chr12:34232590 T/C cg19457237 chr12:34500585 NA -0.41 -5.61 -0.33 4.99e-8 Morning vs. evening chronotype; CESC cis rs34779708 0.931 rs4934700 chr10:35310842 A/G cg04310649 chr10:35416472 CREM -0.5 -5.98 -0.34 7.34e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg06784218 chr1:46089804 CCDC17 -0.29 -5.09 -0.3 6.87e-7 High light scatter reticulocyte count; CESC cis rs651907 0.557 rs13099674 chr3:101489629 G/A cg12386194 chr3:101231763 SENP7 0.41 5.14 0.3 5.28e-7 Colorectal cancer; CESC cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg16339924 chr4:17578868 LAP3 0.64 7.91 0.44 6.79e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2404602 0.669 rs1875885 chr15:76638081 G/A cg22467129 chr15:76604101 ETFA -0.38 -5.71 -0.33 3.1e-8 Blood metabolite levels; CESC cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg21248554 chr2:27665150 KRTCAP3 -0.38 -7.53 -0.42 8.15e-13 Total body bone mineral density; CESC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg07870213 chr5:140052090 DND1 -0.59 -6.53 -0.37 3.4e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg10691866 chr7:65817282 TPST1 -0.34 -5.51 -0.32 8.3e-8 Aortic root size; CESC cis rs5769765 0.955 rs8135816 chr22:50291976 G/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.2 -0.3 4.01e-7 Schizophrenia; CESC cis rs2281558 0.837 rs67676850 chr20:25369417 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.61 8.25 0.45 7.67e-15 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg14416726 chr6:151773293 C6orf211;RMND1 0.49 6.18 0.35 2.42e-9 Menarche (age at onset); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg02764006 chr17:65029280 CACNG4 -0.41 -6.07 -0.35 4.29e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2730245 0.636 rs710421 chr7:158668575 T/C cg15303052 chr7:158526867 ESYT2 -0.41 -5.21 -0.3 3.76e-7 Height; CESC cis rs10242455 0.867 rs2687076 chr7:99307268 G/A cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04533189 chr17:64298763 PRKCA 0.52 6.32 0.36 1.11e-9 Gut microbiome composition (summer); CESC cis rs8114671 0.742 rs6058161 chr20:33620026 C/T cg06115741 chr20:33292138 TP53INP2 -0.44 -5.29 -0.31 2.53e-7 Height; CESC cis rs9640161 0.742 rs11983355 chr7:150016697 A/C cg21361702 chr7:150065534 REPIN1 0.54 6.12 0.35 3.39e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs1129187 0.837 rs4714634 chr6:42901120 G/A cg02353165 chr6:42928485 GNMT 0.81 12.41 0.61 3.61e-28 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1707322 0.963 rs11211202 chr1:46292382 C/T cg03146154 chr1:46216737 IPP 0.71 9.79 0.52 1.63e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9818758 0.607 rs73082362 chr3:49113729 C/T cg00383909 chr3:49044727 WDR6 0.89 5.26 0.31 3.03e-7 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs9457247 0.663 rs1894603 chr6:167434686 C/T cg23791538 chr6:167370224 RNASET2 0.52 6.98 0.39 2.41e-11 Crohn's disease; CESC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs2075371 0.932 rs1862048 chr7:133978167 C/G cg16409651 chr16:11680980 LITAF 0.53 6.13 0.35 3.23e-9 Mean platelet volume; CESC cis rs250677 0.958 rs36067 chr5:148417553 T/G cg18129178 chr5:148520854 ABLIM3 -0.52 -5.8 -0.34 1.86e-8 Breast cancer; CESC cis rs7520050 0.966 rs4660317 chr1:46326226 G/A cg03146154 chr1:46216737 IPP -0.48 -6.22 -0.36 1.98e-9 Red blood cell count;Reticulocyte count; CESC cis rs733592 0.507 rs10747529 chr12:48473369 G/A cg04545296 chr12:48745243 ZNF641 -0.29 -5.44 -0.32 1.18e-7 Plateletcrit; CESC trans rs9325144 0.600 rs34138871 chr12:38735261 A/G cg23762105 chr12:34175262 ALG10 -0.45 -6.01 -0.35 5.97e-9 Morning vs. evening chronotype; CESC trans rs11098499 0.913 rs35271032 chr4:120156659 C/T cg25214090 chr10:38739885 LOC399744 0.64 8.57 0.47 8.82e-16 Corneal astigmatism; CESC cis rs9399401 0.710 rs12197866 chr6:142706063 C/T cg04461802 chr6:142623433 GPR126 0.39 5.6 0.33 5.47e-8 Chronic obstructive pulmonary disease; CESC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg00166722 chr3:10149974 C3orf24 0.49 6.08 0.35 4.28e-9 Alzheimer's disease; CESC cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg24296786 chr1:45957014 TESK2 0.63 8.26 0.45 6.93e-15 High light scatter reticulocyte count; CESC cis rs7772486 0.875 rs2073287 chr6:146350264 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.33 0.36 1.07e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs360798 0.532 rs360800 chr2:62954326 C/T cg17519650 chr2:63277830 OTX1 -0.53 -6.51 -0.37 3.71e-10 Coronary artery disease; CESC cis rs9311474 0.713 rs352166 chr3:52238677 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.59 0.32 5.74e-8 Electroencephalogram traits; CESC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.6 -0.33 5.46e-8 Total body bone mineral density; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg06761076 chr22:21056301 TMEM191A 0.51 6.09 0.35 3.92e-9 Psoriatic arthritis; CESC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg18350739 chr11:68623251 NA -0.4 -6.18 -0.36 2.36e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7084402 1.000 rs1427201 chr10:60269755 G/T cg07615347 chr10:60278583 BICC1 -0.57 -8.71 -0.47 3.43e-16 Refractive error; CESC cis rs7116495 0.609 rs577435 chr11:71794681 C/T cg18441811 chr11:71824068 C11orf51 -0.78 -5.03 -0.3 9.03e-7 Severe influenza A (H1N1) infection; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00145757 chr11:118478637 PHLDB1 -0.42 -6.13 -0.35 3.18e-9 Gambling; CESC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg18032046 chr6:28092343 ZSCAN16 -0.48 -6.22 -0.36 1.92e-9 Cardiac Troponin-T levels; CESC cis rs12545109 0.800 rs1437278 chr8:57357024 T/C cg09654669 chr8:57350985 NA -0.6 -6.95 -0.39 2.78e-11 Obesity-related traits; CESC trans rs10411161 0.702 rs8110461 chr19:52383569 A/C cg22319618 chr22:45562946 NUP50 -0.69 -6.75 -0.38 9.37e-11 Breast cancer; CESC cis rs2072732 0.756 rs12041634 chr1:2951034 A/T cg03976712 chr1:2946727 NA 0.33 5.45 0.32 1.17e-7 Plateletcrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20388062 chr1:46713403 RAD54L 0.6 6.76 0.38 8.88e-11 Gut microbiome composition (summer); CESC cis rs11098499 0.644 rs17517414 chr4:120262101 G/C cg09307838 chr4:120376055 NA 0.76 10.27 0.53 4.94e-21 Corneal astigmatism; CESC cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg15541040 chr2:3486749 NA -0.43 -5.48 -0.32 1.01e-7 Neurofibrillary tangles; CESC trans rs9834373 0.550 rs4485681 chr3:78529018 C/G cg21593409 chr16:88706389 IL17C 0.41 6.11 0.35 3.53e-9 Protein quantitative trait loci; CESC cis rs7617480 0.558 rs12715430 chr3:48942855 A/C cg06212747 chr3:49208901 KLHDC8B 0.49 5.65 0.33 4.11e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs2228479 0.850 rs45567439 chr16:89814604 G/A cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs57506017 0.585 rs10950391 chr7:12261829 A/G cg23422036 chr7:12250390 TMEM106B 0.38 5.08 0.3 7.16e-7 Neuroticism; CESC trans rs7615952 0.611 rs2971298 chr3:125602713 G/A cg07211511 chr3:129823064 LOC729375 -0.87 -9.6 -0.51 6.4e-19 Blood pressure (smoking interaction); CESC trans rs11098499 0.542 rs7677836 chr4:120310638 T/A cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg21782813 chr7:2030301 MAD1L1 0.39 5.43 0.32 1.29e-7 Bipolar disorder and schizophrenia; CESC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.87e-17 Tonsillectomy; CESC cis rs7546094 0.967 rs1006298 chr1:113061959 G/C cg22162597 chr1:113214053 CAPZA1 0.37 5.71 0.33 3.06e-8 Platelet distribution width; CESC trans rs17685 0.712 rs28456330 chr7:75810542 A/G cg19862616 chr7:65841803 NCRNA00174 0.84 11.79 0.59 4.43e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg12311346 chr5:56204834 C5orf35 -0.72 -9.08 -0.49 2.64e-17 Type 2 diabetes; CESC cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 5.86e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4834770 1.000 rs6823963 chr4:120242164 A/C cg09307838 chr4:120376055 NA 0.45 5.37 0.31 1.74e-7 Blood protein levels; CESC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg05564831 chr3:52568323 NT5DC2 0.44 6.68 0.38 1.43e-10 Bipolar disorder; CESC trans rs877282 0.891 rs34383514 chr10:800181 T/C cg22713356 chr15:30763199 NA 1.36 13.53 0.64 4.71e-32 Uric acid levels; CESC cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg24308560 chr3:49941425 MST1R 0.62 9.0 0.48 4.41e-17 Intelligence (multi-trait analysis); CESC cis rs6997458 0.742 rs3758076 chr8:86375535 G/C cg21346043 chr8:86351067 CA3 -0.34 -5.1 -0.3 6.48e-7 Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs62064224 0.553 rs6505297 chr17:30765767 A/G cg18200150 chr17:30822561 MYO1D 0.43 5.39 0.31 1.54e-7 Schizophrenia; CESC cis rs1538970 1.000 rs61791368 chr1:45867944 T/C cg06784218 chr1:46089804 CCDC17 0.32 5.26 0.31 2.96e-7 Platelet count; CESC cis rs8020095 0.528 rs6573768 chr14:67824953 T/C cg19548862 chr14:67692701 FAM71D -0.45 -5.34 -0.31 2.04e-7 Depression (quantitative trait); CESC trans rs7944735 0.507 rs10742827 chr11:48102350 C/T cg15704280 chr7:45808275 SEPT13 0.62 7.61 0.42 4.85e-13 Intraocular pressure; CESC cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg26191576 chr14:75389716 RPS6KL1 -0.39 -5.68 -0.33 3.52e-8 Caffeine consumption; CESC cis rs10191773 0.589 rs72831638 chr2:112949212 C/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.71 -6.9 -0.39 3.9e-11 Yeast infection; CESC cis rs2439831 0.850 rs28891769 chr15:44072860 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.7 6.72 0.38 1.14e-10 Lung cancer in ever smokers; CESC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg02376097 chr19:46275166 DMPK 0.38 5.48 0.32 9.91e-8 Coronary artery disease; CESC cis rs2072732 0.821 rs1005471 chr1:2952614 T/C cg22517653 chr1:2918612 NA -0.35 -5.04 -0.3 8.48e-7 Plateletcrit; CESC cis rs2795502 0.882 rs2744093 chr10:43339243 A/G cg20628663 chr10:43360327 NA -0.63 -7.47 -0.42 1.16e-12 Blood protein levels; CESC cis rs2180341 0.842 rs6569476 chr6:127553539 G/A cg24812749 chr6:127587940 RNF146 0.92 10.95 0.56 2.93e-23 Breast cancer; CESC cis rs4253772 0.938 rs41329344 chr22:46636930 C/T cg18190219 chr22:46762943 CELSR1 -0.61 -5.84 -0.34 1.52e-8 LDL cholesterol;Cholesterol, total; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18470468 chr7:98985742 ARPC1B 0.47 6.29 0.36 1.31e-9 Fibrinogen levels; CESC cis rs8014204 0.935 rs1799900 chr14:75367740 G/A cg08847533 chr14:75593920 NEK9 -0.47 -5.79 -0.34 1.94e-8 Caffeine consumption; CESC cis rs3820068 0.603 rs2236215 chr1:15892415 A/C cg13390004 chr1:15929781 NA 0.33 5.22 0.31 3.69e-7 Systolic blood pressure; CESC cis rs765787 0.530 rs1706837 chr15:45519036 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.2 -0.4 6.28e-12 Uric acid levels; CESC cis rs2204008 0.748 rs11180579 chr12:38237830 A/G cg13010199 chr12:38710504 ALG10B 0.52 6.43 0.37 5.91e-10 Bladder cancer; CESC cis rs10791323 0.572 rs4412766 chr11:133742811 A/C cg03690763 chr11:133734501 NA -0.33 -5.68 -0.33 3.62e-8 Childhood ear infection; CESC cis rs826838 0.967 rs11168299 chr12:38902028 G/T cg13010199 chr12:38710504 ALG10B 0.6 8.42 0.46 2.38e-15 Heart rate; CESC cis rs10242455 0.702 rs73713531 chr7:99222379 C/T cg07338983 chr7:99679036 ZNF3 0.71 5.07 0.3 7.63e-7 Blood metabolite levels; CESC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg17971929 chr21:40555470 PSMG1 1.03 15.1 0.68 1.31e-37 Cognitive function; CESC cis rs2273669 0.667 rs12206834 chr6:109303967 T/G cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10791097 0.935 rs4601795 chr11:130729430 T/C cg14779329 chr11:130786720 SNX19 0.37 5.8 0.34 1.85e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9486719 1.000 rs2472880 chr6:96860130 G/A cg18709589 chr6:96969512 KIAA0776 0.5 5.31 0.31 2.29e-7 Migraine;Coronary artery disease; CESC cis rs7712401 0.601 rs28892 chr5:122283826 A/G cg19412675 chr5:122181750 SNX24 -0.42 -5.13 -0.3 5.58e-7 Mean platelet volume; CESC cis rs12477438 1.000 rs57846982 chr2:99921574 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.67 -7.72 -0.43 2.35e-13 Chronic sinus infection; CESC cis rs4594175 0.926 rs4617765 chr14:51598843 T/C cg23942311 chr14:51606299 NA 0.4 5.94 0.34 9.07e-9 Cancer; CESC cis rs11971779 0.793 rs4728464 chr7:139017670 C/T cg07862535 chr7:139043722 LUC7L2 -0.48 -5.91 -0.34 1.03e-8 Diisocyanate-induced asthma; CESC cis rs6060717 0.610 rs6060755 chr20:34606915 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -5.41 -0.32 1.41e-7 Hip circumference adjusted for BMI; CESC cis rs9488822 0.702 rs10872141 chr6:116323246 C/A cg26893134 chr6:116381904 FRK 0.25 6.04 0.35 5.06e-9 Cholesterol, total;LDL cholesterol; CESC cis rs9583531 0.600 rs9555726 chr13:111368316 C/T cg15841412 chr13:111365552 ING1 0.46 5.83 0.34 1.6e-8 Coronary artery disease; CESC cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg04455712 chr21:45112962 RRP1B 0.47 7.68 0.43 3.16e-13 Mean corpuscular volume; CESC cis rs72781680 0.651 rs13019016 chr2:23894773 C/G cg08917208 chr2:24149416 ATAD2B 0.91 8.46 0.46 1.84e-15 Lymphocyte counts; CESC cis rs11764590 0.694 rs11762413 chr7:2090387 C/G cg21782813 chr7:2030301 MAD1L1 -0.41 -5.22 -0.31 3.69e-7 Neuroticism; CESC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg04772025 chr11:68637568 NA 0.54 6.14 0.35 2.97e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs2727020 0.688 rs4929894 chr11:49196333 G/C cg15704280 chr7:45808275 SEPT13 -0.84 -13.4 -0.64 1.29e-31 Coronary artery disease; CESC cis rs4629180 0.593 rs6707517 chr2:102089878 C/T cg04415270 chr2:102091202 RFX8 -0.45 -7.39 -0.41 1.97e-12 Chronic rhinosinusitis with nasal polyps; CESC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.16e-7 Aortic root size; CESC cis rs3806843 0.676 rs2245640 chr5:140029958 A/G cg26395211 chr5:140044315 WDR55 0.52 6.73 0.38 1.06e-10 Depressive symptoms (multi-trait analysis); CESC cis rs12042938 0.600 rs823165 chr1:231769446 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.42 5.57 0.32 6.23e-8 Neuranatomic and neurocognitive phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05306006 chr2:210867127 RPE -0.59 -6.69 -0.38 1.34e-10 Gut microbiome composition (summer); CESC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg08859206 chr1:53392774 SCP2 -0.52 -7.0 -0.4 2.09e-11 Monocyte count; CESC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00512374 chr17:38599682 IGFBP4 -0.48 -6.07 -0.35 4.31e-9 Gut microbiota (bacterial taxa); CESC cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg27398817 chr8:82754497 SNX16 -0.49 -5.62 -0.33 4.85e-8 Diastolic blood pressure; CESC cis rs6088590 0.561 rs6088528 chr20:33156742 G/A cg06115741 chr20:33292138 TP53INP2 0.51 6.53 0.37 3.3e-10 Coronary artery disease; CESC cis rs870825 0.616 rs9631783 chr4:185626511 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18551892 chr11:86667149 FZD4 0.6 7.01 0.4 2.01e-11 Gut microbiome composition (summer); CESC cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg20503657 chr10:835505 NA 1.09 9.95 0.52 4.95e-20 Eosinophil percentage of granulocytes; CESC cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg12365402 chr11:9010492 NRIP3 -0.4 -6.95 -0.39 2.92e-11 Hemoglobin concentration; CESC trans rs1814175 0.817 rs1621090 chr11:49895868 C/A cg03929089 chr4:120376271 NA -0.91 -15.66 -0.69 1.37e-39 Height; CESC trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.3 -0.36 1.26e-9 Neuroticism; CESC cis rs7833790 0.929 rs28464834 chr8:82797356 A/T cg27398817 chr8:82754497 SNX16 0.57 6.86 0.39 4.96e-11 Diastolic blood pressure; CESC cis rs7385804 0.796 rs2432930 chr7:100299024 A/G cg16850897 chr7:100343110 ZAN 0.52 7.17 0.4 7.34e-12 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs3749237 0.595 rs11130199 chr3:49538799 T/C cg06212747 chr3:49208901 KLHDC8B 0.51 6.82 0.39 6.09e-11 Resting heart rate; CESC cis rs3820068 0.705 rs11584209 chr1:15885041 G/T cg18192808 chr1:15853278 DNAJC16 0.44 5.19 0.3 4.21e-7 Systolic blood pressure; CESC cis rs1953600 0.645 rs7071579 chr10:81910278 A/G cg00277334 chr10:82204260 NA 0.41 5.53 0.32 7.61e-8 Sarcoidosis; CESC cis rs763121 0.925 rs1043312 chr22:39131727 T/G cg06022373 chr22:39101656 GTPBP1 0.79 12.94 0.62 5.14e-30 Menopause (age at onset); CESC trans rs1850744 0.510 rs4697901 chr4:9863698 G/T cg06372015 chr11:43602000 MIR129-2 0.59 6.0 0.35 6.4e-9 Economic and political preferences; CESC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg18876405 chr7:65276391 NA -0.53 -7.2 -0.4 6.41e-12 Aortic root size; CESC cis rs6088580 0.634 rs6059835 chr20:33020141 A/G cg24642439 chr20:33292090 TP53INP2 0.52 6.79 0.39 7.18e-11 Glomerular filtration rate (creatinine); CESC cis rs1728785 1.000 rs698716 chr16:68560296 C/T cg02972257 chr16:68554789 NA -0.62 -7.02 -0.4 1.83e-11 Ulcerative colitis; CESC cis rs2034088 0.965 rs4968070 chr17:446162 A/G cg13332499 chr17:408570 NA 0.46 7.23 0.41 5.14e-12 Hip circumference adjusted for BMI; CESC cis rs34638657 0.732 rs10514532 chr16:82200337 C/T cg09439754 chr16:82129088 HSD17B2 0.36 6.34 0.36 9.62e-10 Lung adenocarcinoma; CESC cis rs854765 0.693 rs11657074 chr17:17770355 G/A cg16928487 chr17:17741425 SREBF1 0.6 10.79 0.55 9.76e-23 Total body bone mineral density; CESC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg25072359 chr17:41440525 NA -0.45 -6.7 -0.38 1.28e-10 Menopause (age at onset); CESC cis rs7914558 1.000 rs7911789 chr10:104756374 T/C cg15744005 chr10:104629667 AS3MT -0.34 -5.65 -0.33 4.05e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs3733585 0.699 rs1079128 chr4:9951221 T/C cg02734326 chr4:10020555 SLC2A9 -0.41 -5.8 -0.34 1.89e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8114671 0.935 rs6060282 chr20:33767066 C/T cg24642439 chr20:33292090 TP53INP2 0.44 5.26 0.31 2.95e-7 Height; CESC cis rs9300255 0.602 rs1790126 chr12:123683563 C/T cg05973401 chr12:123451056 ABCB9 0.5 5.74 0.33 2.53e-8 Neutrophil percentage of white cells; CESC cis rs2839186 0.681 rs13047198 chr21:47701835 T/C cg10351095 chr21:47802916 PCNT -0.49 -6.48 -0.37 4.46e-10 Testicular germ cell tumor; CESC cis rs4568518 0.710 rs12699929 chr7:18012257 G/C cg03009463 chr7:17980271 SNX13 0.46 6.0 0.35 6.38e-9 Measles; CESC cis rs4660261 0.545 rs803682 chr1:44362623 G/A cg13606994 chr1:44402422 ARTN -0.38 -6.05 -0.35 4.82e-9 Intelligence (multi-trait analysis); CESC cis rs5995756 0.761 rs5995759 chr22:40006626 T/C cg03390717 chr22:39966585 CACNA1I -0.35 -6.16 -0.35 2.73e-9 Autism spectrum disorder or schizophrenia; CESC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg17949981 chr6:28129498 ZNF389 0.43 5.67 0.33 3.66e-8 Depression; CESC cis rs9911578 0.967 rs4132925 chr17:56938016 C/G cg12560992 chr17:57184187 TRIM37 -0.92 -15.42 -0.69 9.73e-39 Intelligence (multi-trait analysis); CESC cis rs7680126 0.596 rs12511337 chr4:10311972 A/G cg00071950 chr4:10020882 SLC2A9 0.46 5.13 0.3 5.61e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs254562 0.739 rs254577 chr5:134422204 C/T cg23533927 chr7:150548934 ABP1 -0.38 -6.22 -0.36 1.96e-9 Ulcerative colitis; CESC cis rs7395581 0.918 rs1449627 chr11:47290984 T/G cg25783544 chr11:47291846 MADD 0.62 8.26 0.45 6.99e-15 HDL cholesterol; CESC cis rs17384381 1.000 rs12135333 chr1:85890494 C/A cg16011679 chr1:85725395 C1orf52 0.72 7.42 0.41 1.58e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg04871131 chr7:94954202 PON1 -0.49 -6.69 -0.38 1.32e-10 Paraoxonase activity; CESC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.41e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2274273 1.000 rs61508494 chr14:55587297 T/C cg04306507 chr14:55594613 LGALS3 0.32 6.49 0.37 4.2e-10 Protein biomarker; CESC cis rs1030268 0.651 rs12707121 chr7:133496379 A/G cg10665199 chr7:133106180 EXOC4 0.55 5.43 0.32 1.27e-7 Intelligence (multi-trait analysis); CESC cis rs2439831 0.850 rs61390361 chr15:44159842 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.6 0.33 5.26e-8 Lung cancer in ever smokers; CESC cis rs5769765 0.773 rs4075331 chr22:50302850 A/G cg02269571 chr22:50332266 NA -0.5 -6.47 -0.37 4.6e-10 Schizophrenia; CESC cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg17724175 chr1:150552817 MCL1 0.46 7.48 0.42 1.07e-12 Tonsillectomy; CESC cis rs7917772 0.582 rs7907760 chr10:104345197 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.64 0.33 4.41e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9900062 0.586 rs6504249 chr17:62676149 A/G cg02598441 chr17:62777298 LOC146880 -0.49 -5.13 -0.3 5.56e-7 QT interval; CESC cis rs7247513 0.759 rs8110545 chr19:12754898 C/T cg11738485 chr19:12877000 HOOK2 0.49 6.04 0.35 5.21e-9 Bipolar disorder; CESC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg18758796 chr5:131593413 PDLIM4 0.45 6.4 0.37 6.83e-10 Breast cancer; CESC cis rs2688608 0.653 rs12775558 chr10:75570868 G/A cg23231163 chr10:75533350 FUT11 -0.33 -5.07 -0.3 7.65e-7 Inflammatory bowel disease; CESC cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 9.4 0.5 2.76e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9470366 0.848 rs66761782 chr6:36636080 T/C cg08179530 chr6:36648295 CDKN1A 0.51 6.31 0.36 1.14e-9 QRS duration; CESC cis rs1185460 0.967 rs4545564 chr11:118937518 T/C cg23280166 chr11:118938394 VPS11 0.57 8.01 0.44 3.63e-14 Coronary artery disease; CESC cis rs7395581 0.918 rs1052373 chr11:47354787 A/G cg25783544 chr11:47291846 MADD -0.6 -7.91 -0.44 7.01e-14 HDL cholesterol; CESC trans rs9929218 1.000 rs12448448 chr16:68802516 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.44 -0.46 2.13e-15 Colorectal cancer; CESC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.31 -5.07 -0.3 7.35e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs155076 1.000 rs261432 chr13:21865915 G/C cg11317459 chr13:21872234 NA -1.09 -12.49 -0.61 1.86e-28 White matter hyperintensity burden; CESC cis rs2857078 0.772 rs2079008 chr17:42322132 C/A cg19774624 chr17:42201019 HDAC5 0.51 6.65 0.38 1.69e-10 Red cell distribution width;Reticulocyte count; CESC cis rs7084402 0.967 rs3001717 chr10:60329125 A/G cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs12220238 1.000 rs7905536 chr10:75997209 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.32 0.36 1.1e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg26597838 chr10:835615 NA 0.76 7.38 0.41 2.08e-12 Eosinophil percentage of granulocytes; CESC cis rs11098499 0.618 rs6858383 chr4:120296772 T/C cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg20607287 chr7:12443886 VWDE -0.76 -10.63 -0.55 3.23e-22 Coronary artery disease; CESC trans rs9929218 0.529 rs2296404 chr16:68729525 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.89 14.39 0.66 4.4e-35 Colorectal cancer; CESC cis rs10887741 0.646 rs2077773 chr10:89435501 G/A cg13926569 chr10:89418898 PAPSS2 0.47 7.15 0.4 8.25e-12 Exercise (leisure time); CESC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg26314531 chr2:26401878 FAM59B -0.62 -6.88 -0.39 4.38e-11 Gut microbiome composition (summer); CESC cis rs6456156 1.000 rs6456156 chr6:167522300 T/C cg23791538 chr6:167370224 RNASET2 -0.4 -5.05 -0.3 8.04e-7 Primary biliary cholangitis; CESC cis rs3096299 0.679 rs3102338 chr16:89442250 C/G cg08822215 chr16:89438651 ANKRD11 -0.47 -7.46 -0.42 1.27e-12 Multiple myeloma (IgH translocation); CESC cis rs7666738 0.830 rs35822567 chr4:98654138 G/A cg05340658 chr4:99064831 C4orf37 0.76 10.99 0.56 2.11e-23 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs68178216 chr17:37526241 A/C cg15445000 chr17:37608096 MED1 -0.41 -6.54 -0.37 3.23e-10 Glomerular filtration rate (creatinine); CESC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg22920501 chr2:26401640 FAM59B -0.67 -8.12 -0.45 1.72e-14 Gut microbiome composition (summer); CESC cis rs113835537 0.529 rs117112180 chr11:66293273 A/G cg22134325 chr11:66188745 NPAS4 0.45 6.74 0.38 9.86e-11 Airway imaging phenotypes; CESC cis rs9921192 1.000 rs2892165 chr16:4324293 A/T cg00021532 chr16:4324280 TFAP4 0.9 13.97 0.65 1.33e-33 Prostate-specific antigen levels; CESC cis rs6570726 0.967 rs374728 chr6:145854598 T/A cg05347473 chr6:146136440 FBXO30 0.48 6.44 0.37 5.7e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22359107 chr11:18655812 SPTY2D1 -0.43 -6.2 -0.36 2.15e-9 Gambling; CESC cis rs3857067 1.000 rs6532454 chr4:95019067 G/A cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.0 -0.44 3.9e-14 QT interval; CESC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.75 0.38 9.1e-11 Bipolar disorder; CESC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg17971929 chr21:40555470 PSMG1 -0.86 -12.62 -0.61 6.59e-29 Cognitive function; CESC cis rs7659604 1.000 rs28433617 chr4:122664138 C/A cg19671926 chr4:122722719 EXOSC9 -0.44 -5.16 -0.3 4.8e-7 Type 2 diabetes; CESC cis rs6502050 0.835 rs7220639 chr17:80146866 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.54 -0.37 3.19e-10 Life satisfaction; CESC cis rs1499614 1.000 rs2659911 chr7:66158420 G/A cg12463550 chr7:65579703 CRCP 0.73 5.73 0.33 2.78e-8 Gout; CESC cis rs4930561 0.765 rs7931502 chr11:67959607 A/C cg16338278 chr11:67432957 ALDH3B2 -0.44 -5.53 -0.32 7.83e-8 Breast cancer in childhood cancer survivors;IgG glycosylation; CESC cis rs9911578 1.000 rs3744109 chr17:56594197 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC trans rs7824557 0.564 rs2736290 chr8:11234298 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -6.25 -0.36 1.65e-9 Retinal vascular caliber; CESC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg24503407 chr1:205819492 PM20D1 0.42 5.9 0.34 1.1e-8 Menarche (age at onset); CESC cis rs7247513 0.701 rs8107642 chr19:12766370 C/T cg01871581 chr19:12707946 ZNF490 -0.85 -13.32 -0.63 2.57e-31 Bipolar disorder; CESC cis rs854765 0.647 rs7212447 chr17:17987067 G/A cg04398451 chr17:18023971 MYO15A -0.75 -11.06 -0.56 1.21e-23 Total body bone mineral density; CESC cis rs4568518 0.530 rs7802064 chr7:17994853 A/G cg03009463 chr7:17980271 SNX13 0.45 5.88 0.34 1.21e-8 Measles; CESC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg12373951 chr3:133503437 NA -0.4 -5.7 -0.33 3.25e-8 Iron status biomarkers; CESC cis rs1949733 0.655 rs2631736 chr4:8478421 C/G cg11789530 chr4:8429930 ACOX3 -0.7 -9.91 -0.52 6.83e-20 Response to antineoplastic agents; CESC cis rs7116495 0.867 rs612255 chr11:71778664 A/G cg10381502 chr11:71823885 C11orf51 -1.15 -7.22 -0.41 5.52e-12 Severe influenza A (H1N1) infection; CESC cis rs7116495 0.881 rs7930544 chr11:71737354 C/T cg10381502 chr11:71823885 C11orf51 -0.64 -5.21 -0.3 3.81e-7 Severe influenza A (H1N1) infection; CESC cis rs740698 0.529 rs9895414 chr17:60793399 A/C cg13195520 chr17:60813227 MARCH10 -0.34 -5.65 -0.33 4.14e-8 Pulse pressure; CESC cis rs965469 0.901 rs7270135 chr20:3247922 T/C cg25506879 chr20:3388711 C20orf194 -0.63 -6.67 -0.38 1.52e-10 IFN-related cytopenia; CESC cis rs2933343 0.700 rs876754 chr3:128627753 T/C cg11901034 chr3:128598214 ACAD9 -0.34 -5.04 -0.3 8.49e-7 IgG glycosylation; CESC cis rs2013441 0.670 rs4924802 chr17:19955895 G/T cg12073167 chr17:19770448 ULK2 -0.43 -5.11 -0.3 6.19e-7 Obesity-related traits; CESC cis rs9815354 0.812 rs73071203 chr3:41977464 A/C cg03022575 chr3:42003672 ULK4 0.67 5.95 0.34 8.63e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg18016565 chr1:150552671 MCL1 -0.43 -7.12 -0.4 1.02e-11 Tonsillectomy; CESC cis rs7827545 0.545 rs1867062 chr8:135559079 G/A cg17885191 chr8:135476712 NA 0.54 5.95 0.34 8.57e-9 Hypertension (SNP x SNP interaction); CESC cis rs9512730 0.871 rs7992877 chr13:28066866 C/G cg08193333 chr13:27998609 GTF3A -0.39 -5.46 -0.32 1.07e-7 Schizophrenia; CESC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg12412775 chr1:25698385 RHCE -0.31 -5.49 -0.32 9.57e-8 Erythrocyte sedimentation rate; CESC cis rs2295359 0.892 rs10789224 chr1:67605134 C/T cg17031739 chr1:67600172 NA -0.39 -5.32 -0.31 2.18e-7 Psoriasis; CESC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.67 -0.33 3.68e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1008375 1.000 rs10011865 chr4:17645710 G/A cg02297831 chr4:17616191 MED28 0.53 6.71 0.38 1.2e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs34779708 0.897 rs4934716 chr10:35369299 A/G cg03585969 chr10:35415529 CREM 0.76 10.09 0.53 1.8e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs66887589 0.837 rs7661498 chr4:120408108 T/C cg09307838 chr4:120376055 NA 0.53 7.12 0.4 1.04e-11 Diastolic blood pressure; CESC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg22875332 chr1:76189707 ACADM 0.66 7.87 0.44 9.37e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg21770322 chr7:97807741 LMTK2 0.59 9.02 0.48 4.02e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs2243480 0.901 rs2456483 chr7:65461575 T/C cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs2576037 0.796 rs2576041 chr18:44580919 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.61 -8.65 -0.47 4.91e-16 Personality dimensions; CESC cis rs921968 0.542 rs630858 chr2:219409689 C/A cg02176678 chr2:219576539 TTLL4 0.5 9.0 0.48 4.36e-17 Mean corpuscular hemoglobin concentration; CESC trans rs9325144 0.600 rs7965877 chr12:38743697 G/T cg23762105 chr12:34175262 ALG10 -0.45 -6.02 -0.35 5.64e-9 Morning vs. evening chronotype; CESC cis rs8062405 1.000 rs7205323 chr16:28865892 C/T cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2243480 1.000 rs451396 chr7:65484074 T/A cg13147721 chr7:65941812 NA -0.89 -8.55 -0.47 9.65e-16 Diabetic kidney disease; CESC cis rs10242455 0.557 rs34943973 chr7:99032517 G/A cg25640893 chr7:99214727 ZNF498 1.11 6.71 0.38 1.2e-10 Blood metabolite levels; CESC cis rs6496667 1.000 rs7178496 chr15:90896959 C/T cg22089800 chr15:90895588 ZNF774 0.57 5.76 0.33 2.27e-8 Rheumatoid arthritis; CESC cis rs1983170 0.736 rs11589162 chr1:91974743 C/G cg02896835 chr1:92012615 NA 0.56 6.03 0.35 5.56e-9 Eosinophil percentage of white cells; CESC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg17724175 chr1:150552817 MCL1 0.33 5.08 0.3 6.98e-7 Melanoma; CESC cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.36 5.25 0.31 3.11e-7 Schizophrenia; CESC cis rs67478160 0.643 rs11847468 chr14:104220295 G/A cg01849466 chr14:104193079 ZFYVE21 -0.49 -6.81 -0.39 6.38e-11 Schizophrenia; CESC cis rs861020 0.630 rs685248 chr1:210008367 C/G cg05527609 chr1:210001259 C1orf107 0.73 9.57 0.51 8.2e-19 Orofacial clefts; CESC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs8180040 0.620 rs11917361 chr3:47070497 G/T cg27129171 chr3:47204927 SETD2 -0.66 -10.41 -0.54 1.7e-21 Colorectal cancer; CESC cis rs4253772 0.514 rs11704878 chr22:46714664 C/T cg00784671 chr22:46762841 CELSR1 -0.56 -5.74 -0.33 2.63e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6484504 0.576 rs158140 chr11:31212971 T/C cg14844989 chr11:31128820 NA -0.41 -5.86 -0.34 1.34e-8 Red blood cell count; CESC cis rs854765 0.547 rs2955378 chr17:17930253 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.41 0.46 2.62e-15 Total body bone mineral density; CESC cis rs561341 1.000 rs530715 chr17:30320544 T/G cg12193833 chr17:30244370 NA -0.59 -5.99 -0.35 6.95e-9 Hip circumference adjusted for BMI; CESC cis rs6674176 0.660 rs2108202 chr1:44395786 A/G cg13606994 chr1:44402422 ARTN 0.39 6.09 0.35 4.01e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7116495 0.786 rs4479013 chr11:71673732 C/G cg26138937 chr11:71823887 C11orf51 -0.79 -6.51 -0.37 3.77e-10 Severe influenza A (H1N1) infection; CESC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.18 0.3 4.4e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1035144 0.713 rs2284730 chr14:81464901 T/C cg06600135 chr14:81408086 NA 0.43 5.61 0.33 5.1e-8 Male sexual orientation; CESC cis rs4604732 0.631 rs34330532 chr1:247626844 G/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.21e-14 Blood protein levels; CESC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC trans rs61148964 0.826 rs58430765 chr22:37235632 G/A cg22032385 chr2:236721769 AGAP1 0.57 6.25 0.36 1.64e-9 Scarlet fever; CESC cis rs11122272 0.735 rs2790880 chr1:231534259 C/T cg06096015 chr1:231504339 EGLN1 0.39 5.6 0.33 5.38e-8 Hemoglobin concentration; CESC cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.78e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3105593 0.563 rs4775899 chr15:50967723 T/C cg08437265 chr15:50716283 USP8 0.41 5.2 0.3 4e-7 QT interval; CESC trans rs2727020 0.823 rs7102374 chr11:49261795 G/A cg15704280 chr7:45808275 SEPT13 0.81 10.94 0.56 3.07e-23 Coronary artery disease; CESC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg02187348 chr16:89574699 SPG7 0.73 10.36 0.54 2.47e-21 Multiple myeloma (IgH translocation); CESC cis rs2635047 0.967 rs2684820 chr18:44664304 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 6.4 0.37 6.95e-10 Educational attainment; CESC cis rs2276314 1.000 rs58054756 chr18:33554053 G/C cg19628046 chr18:33552617 C18orf21 0.57 6.41 0.37 6.53e-10 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7208859 0.673 rs73277986 chr17:29196197 C/T cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7296418 0.619 rs7139321 chr12:123719528 T/G cg00376283 chr12:123451042 ABCB9 0.63 8.76 0.47 2.42e-16 Platelet count; CESC cis rs11750568 0.967 rs1549602 chr5:178512136 A/G cg10208897 chr5:178548229 ADAMTS2 -0.39 -5.44 -0.32 1.23e-7 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14995492 chr5:122971951 NA -0.38 -6.09 -0.35 4.03e-9 Gut microbiota (bacterial taxa); CESC cis rs2180341 0.814 rs6914131 chr6:127737489 T/C cg24812749 chr6:127587940 RNF146 0.85 12.06 0.6 5.49e-27 Breast cancer; CESC cis rs72945132 0.882 rs17160777 chr11:70163723 T/C cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg09699651 chr6:150184138 LRP11 0.39 5.04 0.3 8.83e-7 Lung cancer; CESC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg15145296 chr3:125709740 NA -0.48 -5.24 -0.31 3.22e-7 Blood pressure (smoking interaction); CESC cis rs9435341 0.965 rs2335104 chr1:107583641 A/T cg09367891 chr1:107599246 PRMT6 0.6 7.18 0.4 7.15e-12 Facial morphology (factor 21, depth of nasal alae); CESC cis rs10493773 0.775 rs12739713 chr1:86150378 C/T cg17807903 chr1:86174739 ZNHIT6 -0.38 -5.24 -0.31 3.3e-7 Urate levels in overweight individuals; CESC cis rs9309473 0.579 rs1852644 chr2:73597718 A/G cg20560298 chr2:73613845 ALMS1 -0.46 -6.55 -0.37 3.03e-10 Metabolite levels; CESC trans rs2908835 0.705 rs2965701 chr12:11637026 G/A cg09915232 chr8:1879280 ARHGEF10 -0.62 -6.13 -0.35 3.2e-9 Information processing speed; CESC cis rs910316 1.000 rs10142626 chr14:75555636 A/T cg08847533 chr14:75593920 NEK9 1.01 19.43 0.77 6.73e-53 Height; CESC cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg17427002 chr7:12443146 VWDE -0.53 -5.18 -0.3 4.34e-7 Coronary artery disease; CESC cis rs9916302 0.904 rs4794814 chr17:37696852 G/A cg15445000 chr17:37608096 MED1 0.42 6.97 0.39 2.52e-11 Glomerular filtration rate (creatinine); CESC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg06634786 chr22:41940651 POLR3H 0.69 6.8 0.39 6.88e-11 Vitiligo; CESC trans rs7937682 0.924 rs10891288 chr11:111552053 G/T cg18187862 chr3:45730750 SACM1L -0.5 -6.47 -0.37 4.66e-10 Primary sclerosing cholangitis; CESC cis rs524281 0.648 rs10896089 chr11:65936292 A/G cg14036092 chr11:66035641 RAB1B -0.53 -5.22 -0.31 3.65e-7 Electroencephalogram traits; CESC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg13206674 chr6:150067644 NUP43 0.42 5.77 0.33 2.16e-8 Lung cancer; CESC cis rs10751667 0.643 rs10751671 chr11:944479 T/G cg20946044 chr11:1010712 AP2A2 -0.39 -5.43 -0.32 1.24e-7 Alzheimer's disease (late onset); CESC cis rs7100689 0.577 rs9420359 chr10:82054873 C/T cg00277334 chr10:82204260 NA -0.54 -7.07 -0.4 1.35e-11 Post bronchodilator FEV1; CESC cis rs2204008 0.743 rs11182052 chr12:38450421 T/C cg26384229 chr12:38710491 ALG10B 0.66 10.22 0.53 6.79e-21 Bladder cancer; CESC trans rs10242455 0.702 rs3823813 chr7:99049389 G/A cg09045935 chr12:6379348 NA 0.9 6.5 0.37 3.97e-10 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10548669 chr15:37782940 NA -0.54 -6.39 -0.37 7.24e-10 Gut microbiome composition (summer); CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg08204369 chr17:73150733 HN1 0.45 6.05 0.35 4.97e-9 Obesity-related traits; CESC cis rs3820068 0.603 rs72647118 chr1:15956535 G/T cg13390004 chr1:15929781 NA 0.37 5.9 0.34 1.12e-8 Systolic blood pressure; CESC cis rs34286592 0.929 rs1057452 chr16:29833714 A/G cg27338089 chr16:29820515 MAZ -0.54 -5.35 -0.31 1.88e-7 Multiple sclerosis; CESC cis rs7429990 0.965 rs9814961 chr3:48017617 A/G cg11946769 chr3:48343235 NME6 0.44 5.36 0.31 1.83e-7 Educational attainment (years of education); CESC cis rs9911578 0.730 rs55759249 chr17:57027135 A/G cg05425664 chr17:57184151 TRIM37 0.46 5.36 0.31 1.77e-7 Intelligence (multi-trait analysis); CESC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg06221963 chr1:154839813 KCNN3 -0.7 -12.33 -0.6 6.34e-28 Prostate cancer; CESC cis rs7523050 0.643 rs71655970 chr1:109403895 A/G cg08274380 chr1:109419600 GPSM2 0.86 5.77 0.33 2.2e-8 Fat distribution (HIV); CESC cis rs7408868 0.908 rs10418660 chr19:15278635 A/G cg14696996 chr19:15285081 NOTCH3 1.11 11.94 0.59 1.43e-26 Pulse pressure; CESC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg14262678 chr6:151773367 RMND1;C6orf211 0.66 9.39 0.5 2.8e-18 Menarche (age at onset); CESC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.85 9.4 0.5 2.76e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7089973 0.585 rs7907837 chr10:116610690 G/T cg25233709 chr10:116636983 FAM160B1 0.4 6.63 0.38 1.93e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06192289 chr12:102513805 NUP37;C12orf48 -0.43 -6.0 -0.35 6.42e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2652822 1.000 rs2652822 chr15:63422772 C/T cg02713581 chr15:63449717 RPS27L -0.55 -7.28 -0.41 3.89e-12 Metabolic traits; CESC cis rs651907 0.557 rs62284198 chr3:101474699 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 6.77 0.38 8.14e-11 Colorectal cancer; CESC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.17e-9 Menopause (age at onset); CESC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg22920501 chr2:26401640 FAM59B -0.67 -8.03 -0.44 3.28e-14 Gut microbiome composition (summer); CESC cis rs1023500 0.505 rs134885 chr22:42673811 C/G cg05082376 chr22:42548792 NA -0.39 -5.86 -0.34 1.37e-8 Schizophrenia; CESC cis rs2439831 1.000 rs2245054 chr15:43751909 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.14 0.6 2.88e-27 Lung cancer in ever smokers; CESC cis rs5758659 0.569 rs133294 chr22:42382805 C/T cg15557168 chr22:42548783 NA -0.47 -6.92 -0.39 3.46e-11 Cognitive function; CESC cis rs11677416 1.000 rs1878320 chr2:113544467 T/C cg27083787 chr2:113543245 IL1A 0.42 5.28 0.31 2.72e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs2839186 0.869 rs17176513 chr21:47682428 A/G cg00815214 chr21:47717953 NA -0.35 -5.12 -0.3 5.98e-7 Testicular germ cell tumor; CESC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg15445000 chr17:37608096 MED1 0.4 6.47 0.37 4.67e-10 Glomerular filtration rate (creatinine); CESC cis rs2115536 0.730 rs4238512 chr15:80183898 A/C cg00225070 chr15:80189496 MTHFS -0.5 -6.85 -0.39 5.21e-11 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs3026101 0.624 rs1065483 chr17:5284770 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.49 6.59 0.38 2.41e-10 Body mass index; CESC cis rs7044106 0.690 rs10739569 chr9:123361027 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.62 8.61 0.47 6.81e-16 Hip circumference adjusted for BMI; CESC cis rs1144333 0.850 rs1144341 chr1:76282659 T/G cg10523679 chr1:76189770 ACADM -0.58 -5.53 -0.32 7.84e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs7247513 0.701 rs8107642 chr19:12766370 C/T cg11738485 chr19:12877000 HOOK2 0.48 5.93 0.34 9.25e-9 Bipolar disorder; CESC cis rs6120849 0.901 rs6088738 chr20:33747331 A/G cg24642439 chr20:33292090 TP53INP2 -0.57 -6.24 -0.36 1.75e-9 Protein C levels; CESC trans rs877282 0.755 rs11253399 chr10:790030 T/A cg22713356 chr15:30763199 NA 1.11 11.99 0.59 9.56e-27 Uric acid levels; CESC trans rs459571 0.629 rs441233 chr9:136876021 A/G cg10765909 chr12:53715428 AAAS 0.51 6.1 0.35 3.7e-9 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16681104 chr6:159550158 NA -0.56 -6.79 -0.38 7.37e-11 Gut microbiome composition (summer); CESC cis rs922692 0.773 rs2904220 chr15:79076704 G/T cg04896959 chr15:78267971 NA 0.35 5.1 0.3 6.61e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg12419862 chr22:24373484 LOC391322 0.71 9.55 0.51 9.07e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg18099408 chr3:52552593 STAB1 -0.31 -5.19 -0.3 4.19e-7 Bipolar disorder; CESC cis rs12136530 0.550 rs904964 chr1:19697065 T/C cg01832549 chr1:19774989 CAPZB -0.41 -5.27 -0.31 2.8e-7 Lead levels in blood; CESC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.94 -0.56 3.04e-23 Alzheimer's disease; CESC cis rs7829975 0.501 rs2980769 chr8:8320291 G/A cg15556689 chr8:8085844 FLJ10661 0.63 8.52 0.46 1.2e-15 Mood instability; CESC cis rs2249625 0.874 rs1819067 chr6:72849139 A/C cg18830697 chr6:72922368 RIMS1 -0.41 -5.89 -0.34 1.17e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg07697082 chr8:82753677 SNX16 0.41 6.24 0.36 1.69e-9 Diastolic blood pressure; CESC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg06481639 chr22:41940642 POLR3H -0.65 -6.55 -0.37 2.98e-10 Vitiligo; CESC cis rs1975974 0.574 rs17052370 chr17:21736353 A/G cg18423549 chr17:21743878 NA 0.64 9.68 0.51 3.62e-19 Psoriasis; CESC cis rs1707322 1.000 rs1613296 chr1:46546852 A/C cg06784218 chr1:46089804 CCDC17 -0.33 -5.08 -0.3 7.18e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23860436 chr12:58378763 NA -0.63 -7.22 -0.41 5.65e-12 Gut microbiome composition (summer); CESC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg22920501 chr2:26401640 FAM59B 0.78 8.59 0.47 7.48e-16 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02970861 chr11:62359288 TUT1 -0.47 -6.65 -0.38 1.65e-10 Gambling; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01708236 chr6:44233446 NFKBIE -0.47 -6.17 -0.35 2.6e-9 Fibrinogen levels; CESC cis rs7684253 0.565 rs12641030 chr4:57803505 A/G cg21154227 chr4:57904332 IGFBP7 0.37 5.4 0.31 1.47e-7 Migraine; CESC cis rs2549003 0.933 rs3846731 chr5:131814264 T/C cg00255919 chr5:131827918 IRF1 0.51 8.71 0.47 3.26e-16 Asthma (sex interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10211485 chr17:655108 ELP2P;GEMIN4 -0.61 -7.2 -0.4 6.13e-12 Gut microbiome composition (summer); CESC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg13770153 chr20:60521292 NA 0.53 6.71 0.38 1.15e-10 Body mass index; CESC cis rs7208859 0.623 rs8075341 chr17:29136565 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg12667521 chr19:29218732 NA 0.49 6.69 0.38 1.32e-10 Methadone dose in opioid dependence; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25535789 chr19:6211926 MLLT1 -0.42 -6.27 -0.36 1.46e-9 Gut microbiota (bacterial taxa); CESC cis rs7208859 0.573 rs8064686 chr17:29134839 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1348850 0.574 rs4893834 chr2:178442288 C/T cg23306229 chr2:178417860 TTC30B -0.57 -5.57 -0.32 6.27e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2404602 0.552 rs4886823 chr15:76965402 A/G cg00316803 chr15:76480434 C15orf27 0.4 5.67 0.33 3.8e-8 Blood metabolite levels; CESC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg11247378 chr22:39784982 NA 0.62 9.02 0.48 3.97e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs116095464 0.558 rs56342538 chr5:225796 T/C cg10591111 chr5:226296 SDHA -0.52 -6.52 -0.37 3.47e-10 Breast cancer; CESC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg17971929 chr21:40555470 PSMG1 -0.54 -7.05 -0.4 1.56e-11 Menarche (age at onset); CESC cis rs2070488 0.804 rs2268755 chr3:38501916 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.8 -13.05 -0.63 2.09e-30 Electrocardiographic conduction measures; CESC cis rs9443645 0.901 rs9352664 chr6:79566162 G/T cg05283184 chr6:79620031 NA -0.43 -6.76 -0.38 8.6e-11 Intelligence (multi-trait analysis); CESC trans rs2727020 0.636 rs11040368 chr11:49453602 C/A cg15704280 chr7:45808275 SEPT13 -0.91 -15.85 -0.7 3.05e-40 Coronary artery disease; CESC cis rs7260538 0.773 rs1552223 chr19:41525952 A/G cg27089200 chr19:41531976 NA -0.34 -5.17 -0.3 4.69e-7 DDT metabolite (p,p'-DDE levels); CESC cis rs7772486 0.875 rs10457795 chr6:146415665 A/G cg23711669 chr6:146136114 FBXO30 0.83 12.44 0.61 2.65e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg27297192 chr10:134578999 INPP5A 0.4 5.13 0.3 5.54e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg14773178 chr5:1868261 NA 0.32 5.76 0.33 2.3e-8 Cardiovascular disease risk factors; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg07049977 chr2:37458536 CEBPZ;C2orf56 0.5 6.55 0.37 3e-10 Breast cancer;Type 2 diabetes; CESC cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg11752832 chr7:134001865 SLC35B4 0.51 6.65 0.38 1.69e-10 Mean platelet volume; CESC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg12412775 chr1:25698385 RHCE -0.31 -5.55 -0.32 7.06e-8 Erythrocyte sedimentation rate; CESC cis rs10465746 0.653 rs11163877 chr1:84441848 T/A cg10977910 chr1:84465055 TTLL7 0.52 7.06 0.4 1.44e-11 Obesity-related traits; CESC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.76 -10.27 -0.53 4.83e-21 Mean platelet volume; CESC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg04369109 chr6:150039330 LATS1 -0.43 -6.11 -0.35 3.56e-9 Lung cancer; CESC cis rs1707322 0.716 rs6699444 chr1:46135120 G/C cg06784218 chr1:46089804 CCDC17 0.41 7.12 0.4 1.04e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg26408565 chr15:76604113 ETFA -0.42 -6.2 -0.36 2.16e-9 Blood metabolite levels; CESC cis rs10779751 1.000 rs6670821 chr1:11308762 T/C cg08854313 chr1:11322531 MTOR 0.8 10.83 0.55 6.99e-23 Body mass index; CESC cis rs9911578 0.835 rs58647683 chr17:56483194 T/C cg05425664 chr17:57184151 TRIM37 0.46 6.36 0.36 8.86e-10 Intelligence (multi-trait analysis); CESC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg11644478 chr21:40555479 PSMG1 -0.79 -11.71 -0.58 8.34e-26 Cognitive function; CESC cis rs12711979 0.509 rs10191674 chr2:3827891 C/T cg17052675 chr2:3827356 NA -0.61 -10.33 -0.54 3.04e-21 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs7674212 0.570 rs2126470 chr4:104061762 T/C cg16532752 chr4:104119610 CENPE -0.45 -6.22 -0.36 1.95e-9 Type 2 diabetes; CESC cis rs2228479 1.000 rs2228479 chr16:89985940 G/A cg06558623 chr16:89946397 TCF25 1.14 8.77 0.47 2.27e-16 Skin colour saturation; CESC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg04369109 chr6:150039330 LATS1 -0.45 -6.23 -0.36 1.78e-9 Lung cancer; CESC cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg07636037 chr3:49044803 WDR6 1.07 19.82 0.77 3.09e-54 Parkinson's disease; CESC cis rs9611565 0.568 rs5758441 chr22:42132888 C/A cg03806693 chr22:41940476 POLR3H 0.78 9.54 0.51 9.81e-19 Vitiligo; CESC cis rs6088580 0.634 rs9789792 chr20:32957709 G/A cg24642439 chr20:33292090 TP53INP2 -0.52 -6.83 -0.39 5.7e-11 Glomerular filtration rate (creatinine); CESC cis rs2737618 0.698 rs2737681 chr1:200091864 C/T cg21825944 chr1:200113062 NR5A2 -0.38 -5.4 -0.31 1.49e-7 Uric acid levels; CESC cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.15e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6496667 1.000 rs75444304 chr15:90894246 C/T cg22089800 chr15:90895588 ZNF774 0.51 5.17 0.3 4.67e-7 Rheumatoid arthritis; CESC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg22907277 chr7:1156413 C7orf50 0.37 5.41 0.32 1.38e-7 Longevity;Endometriosis; CESC cis rs938554 0.737 rs11723439 chr4:9951819 C/T cg00071950 chr4:10020882 SLC2A9 -0.66 -7.02 -0.4 1.85e-11 Blood metabolite levels; CESC cis rs9549367 0.789 rs8001506 chr13:113867153 A/C cg18105134 chr13:113819100 PROZ -0.72 -9.4 -0.5 2.68e-18 Platelet distribution width; CESC cis rs9549260 0.816 rs7328594 chr13:41253764 T/C cg21288729 chr13:41239152 FOXO1 0.64 8.19 0.45 1.09e-14 Red blood cell count; CESC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg25036284 chr2:26402008 FAM59B 0.86 9.4 0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs56046484 0.703 rs12439802 chr15:85520329 C/G cg08123816 chr15:85640762 PDE8A -0.44 -5.32 -0.31 2.2e-7 Testicular germ cell tumor; CESC cis rs2075371 0.863 rs34231360 chr7:133944988 A/C cg11752832 chr7:134001865 SLC35B4 0.51 6.49 0.37 4.14e-10 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02522952 chr6:119671260 MAN1A1 0.55 6.61 0.38 2.15e-10 Gut microbiome composition (summer); CESC cis rs7998202 0.667 rs914018 chr13:113354819 A/G cg02820901 chr13:113351484 ATP11A 0.65 5.78 0.33 2.05e-8 Glycated hemoglobin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16856100 chr3:17783647 TBC1D5 0.61 6.91 0.39 3.67e-11 Gut microbiome composition (summer); CESC cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg23711669 chr6:146136114 FBXO30 -1.0 -15.4 -0.69 1.15e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.47 0.46 1.72e-15 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg11494091 chr17:61959527 GH2 0.73 12.49 0.61 1.88e-28 Prudent dietary pattern; CESC cis rs6088580 0.634 rs3736762 chr20:33037336 C/T cg08999081 chr20:33150536 PIGU 0.65 11.42 0.57 7.86e-25 Glomerular filtration rate (creatinine); CESC cis rs11098499 0.644 rs7676296 chr4:120555687 A/G cg24375607 chr4:120327624 NA 0.41 5.14 0.3 5.23e-7 Corneal astigmatism; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16266895 chr12:101674004 UTP20 -0.48 -6.92 -0.39 3.49e-11 Gambling; CESC cis rs17401966 1.000 rs3748578 chr1:10420918 A/G cg15208524 chr1:10270712 KIF1B -0.43 -5.5 -0.32 8.87e-8 Hepatocellular carcinoma; CESC cis rs4803468 1.000 rs4803468 chr19:41922352 A/G cg09537434 chr19:41945824 ATP5SL -1.11 -20.39 -0.78 3.11e-56 Height; CESC cis rs1008375 0.966 rs6449329 chr4:17703677 T/C cg02297831 chr4:17616191 MED28 0.48 5.79 0.33 2.01e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4843747 0.671 rs8062855 chr16:88106941 T/C cg03395651 chr16:88107091 BANP 0.46 5.36 0.31 1.85e-7 Menopause (age at onset); CESC cis rs3768617 0.510 rs4651143 chr1:183097398 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.27 0.66 1.13e-34 Fuchs's corneal dystrophy; CESC cis rs60871478 1.000 rs34086011 chr7:805430 C/T cg05535760 chr7:792225 HEATR2 0.88 11.01 0.56 1.78e-23 Cerebrospinal P-tau181p levels; CESC cis rs644799 0.648 rs1255182 chr11:95472391 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.47 6.81 0.39 6.49e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs1044826 1.000 rs747346 chr3:139231914 A/C cg05129325 chr1:215255161 KCNK2 -0.31 -6.11 -0.35 3.53e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23614413 chr1:45120431 TMEM53 -0.54 -6.11 -0.35 3.48e-9 Gut microbiome composition (summer); CESC cis rs6120849 0.754 rs6120813 chr20:33642112 T/C cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs3126085 0.935 rs11204947 chr1:152218257 G/T cg03465714 chr1:152285911 FLG 0.45 5.37 0.31 1.73e-7 Atopic dermatitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25300318 chr2:200527297 NA 0.5 6.9 0.39 3.76e-11 Fibrinogen levels; CESC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg22823121 chr1:150693482 HORMAD1 0.45 6.37 0.36 8.45e-10 Melanoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16759895 chr16:3451202 ZNF174;ZNF434 0.55 6.08 0.35 4.19e-9 Gut microbiome composition (summer); CESC cis rs9929218 1.000 rs12446575 chr16:68791644 C/G cg02972257 chr16:68554789 NA 0.54 6.25 0.36 1.59e-9 Colorectal cancer; CESC cis rs6582630 0.519 rs12366667 chr12:38332632 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.11 0.35 3.53e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs950776 0.593 rs601079 chr15:78869579 T/A cg24631222 chr15:78858424 CHRNA5 0.44 5.61 0.33 5.17e-8 Sudden cardiac arrest; CESC cis rs6669072 0.647 rs814546 chr1:91239355 G/T cg08895590 chr1:91227319 NA -0.32 -5.52 -0.32 8.16e-8 Cognitive function; CESC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg24549020 chr5:56110836 MAP3K1 0.66 7.43 0.42 1.49e-12 Initial pursuit acceleration; CESC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.76 0.51 1.99e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4566357 0.615 rs2894626 chr2:227916039 T/C cg05526886 chr2:227700861 RHBDD1 -0.51 -6.79 -0.38 7.47e-11 Coronary artery disease; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg02846228 chr16:31102495 VKORC1 -0.51 -6.26 -0.36 1.5e-9 Psoriatic arthritis; CESC cis rs3093024 1.000 rs3093023 chr6:167534290 A/G cg23791538 chr6:167370224 RNASET2 0.42 5.21 0.3 3.82e-7 Rheumatoid arthritis; CESC cis rs889398 0.738 rs7196842 chr16:69923333 T/C cg09409435 chr16:70099608 PDXDC2 0.41 5.06 0.3 7.98e-7 Body mass index; CESC cis rs4150161 0.591 rs3759977 chr16:84221170 T/A cg10106505 chr16:84220380 TAF1C -0.78 -5.68 -0.33 3.51e-8 Systolic blood pressure response to hydrochlorothiazide in hypertension; CESC cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.573 rs7222803 chr17:29119897 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2455799 0.593 rs2047852 chr3:15732539 T/G cg16303742 chr3:15540471 COLQ -0.38 -5.99 -0.35 6.73e-9 Mean platelet volume; CESC cis rs10434923 1.000 rs2091154 chr7:156257405 A/G cg10571168 chr7:156583547 LMBR1 0.6 5.2 0.3 3.99e-7 Childhood ear infection; CESC cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.76 -11.68 -0.58 1.08e-25 Hip circumference adjusted for BMI; CESC cis rs4523957 0.963 rs216178 chr17:2168840 T/C cg16513277 chr17:2031491 SMG6 0.59 8.06 0.44 2.6e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg00033643 chr7:134001901 SLC35B4 0.41 5.34 0.31 1.98e-7 Mean platelet volume; CESC cis rs8020095 0.571 rs10136026 chr14:67410107 C/T cg19548862 chr14:67692701 FAM71D -0.49 -5.98 -0.35 7.01e-9 Depression (quantitative trait); CESC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg17427002 chr7:12443146 VWDE -0.56 -5.85 -0.34 1.42e-8 Coronary artery disease; CESC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg23018236 chr17:30244563 NA -0.45 -5.06 -0.3 7.86e-7 Hip circumference adjusted for BMI; CESC cis rs10191773 0.535 rs72833432 chr2:113102746 T/C cg07905836 chr2:113190072 RGPD8;RGPD5 0.59 5.1 0.3 6.51e-7 Yeast infection; CESC cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.68 0.38 1.44e-10 Eosinophil percentage of white cells; CESC cis rs950776 0.518 rs11632604 chr15:78821914 T/C cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs6502050 0.835 rs7207947 chr17:80145291 A/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.62 -0.38 2.01e-10 Life satisfaction; CESC cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg23583168 chr7:148888333 NA -0.74 -10.77 -0.55 1.13e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs35110281 0.720 rs162374 chr21:44927089 T/C cg21573476 chr21:45109991 RRP1B 0.43 5.92 0.34 9.84e-9 Mean corpuscular volume; CESC cis rs7937682 0.737 rs518294 chr11:111424716 A/T cg22437258 chr11:111473054 SIK2 0.61 7.58 0.42 5.87e-13 Primary sclerosing cholangitis; CESC cis rs35110281 0.744 rs230646 chr21:44918788 A/G cg01579765 chr21:45077557 HSF2BP -0.52 -8.79 -0.47 1.98e-16 Mean corpuscular volume; CESC cis rs2645694 0.626 rs2703122 chr4:77821418 A/C cg10057126 chr4:77819792 ANKRD56 0.59 8.61 0.47 6.84e-16 Emphysema distribution in smoking; CESC cis rs4481887 0.927 rs4244187 chr1:248493511 T/C cg00666640 chr1:248458726 OR2T12 0.35 5.84 0.34 1.55e-8 Common traits (Other); CESC cis rs854765 0.522 rs63721860 chr17:17829576 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.64 9.36 0.5 3.61e-18 Total body bone mineral density; CESC cis rs6088590 0.561 rs6087605 chr20:33180624 G/T cg08999081 chr20:33150536 PIGU 0.7 12.4 0.61 3.7e-28 Coronary artery disease; CESC cis rs8005677 1.000 rs8005677 chr14:23376678 T/C cg01529538 chr14:23388837 RBM23 0.51 6.99 0.39 2.25e-11 Cognitive ability (multi-trait analysis); CESC cis rs6570726 0.902 rs4895678 chr6:145935510 C/T cg05347473 chr6:146136440 FBXO30 0.4 5.53 0.32 7.52e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs9300255 0.543 rs520088 chr12:123522150 C/G cg00376283 chr12:123451042 ABCB9 0.76 9.53 0.51 1.08e-18 Neutrophil percentage of white cells; CESC cis rs6032067 0.777 rs13039211 chr20:43784396 C/T cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10493773 0.630 rs3753790 chr1:86174772 T/C cg17807903 chr1:86174739 ZNHIT6 -0.44 -6.5 -0.37 3.91e-10 Urate levels in overweight individuals; CESC cis rs2130392 0.503 rs2871418 chr4:185654723 A/G cg21366198 chr4:185655624 MLF1IP 0.43 5.83 0.34 1.57e-8 Kawasaki disease; CESC cis rs6543140 0.964 rs2141781 chr2:103082906 G/A cg04239558 chr2:103089729 SLC9A4 0.48 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs7089973 0.604 rs11196943 chr10:116598865 T/C cg03647239 chr10:116582469 FAM160B1 0.44 5.55 0.32 6.83e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs921665 0.915 rs11127382 chr2:3185675 A/T cg00496484 chr2:3153332 NA -0.46 -5.03 -0.3 9.09e-7 World class endurance athleticism; CESC cis rs6502050 0.835 rs7221544 chr17:80087337 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.53 0.37 3.29e-10 Life satisfaction; CESC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg02951883 chr7:2050386 MAD1L1 -0.43 -5.64 -0.33 4.4e-8 Schizophrenia; CESC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg18032046 chr6:28092343 ZSCAN16 -0.43 -5.48 -0.32 9.85e-8 Cardiac Troponin-T levels; CESC cis rs7918232 0.941 rs4749228 chr10:27433618 C/T cg14240646 chr10:27532245 ACBD5 0.69 6.42 0.37 6.15e-10 Breast cancer; CESC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg03264133 chr6:25882463 NA -0.44 -6.32 -0.36 1.12e-9 Intelligence (multi-trait analysis); CESC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg12963246 chr6:28129442 ZNF389 0.41 5.91 0.34 1.04e-8 Cardiac Troponin-T levels; CESC cis rs1728785 1.000 rs1728765 chr16:68589433 G/A cg02972257 chr16:68554789 NA -0.59 -6.79 -0.38 7.32e-11 Ulcerative colitis; CESC cis rs9811920 0.609 rs7638900 chr3:99670773 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 5.44 0.32 1.19e-7 Axial length; CESC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.42e-7 Lung cancer; CESC cis rs9911578 0.704 rs72628393 chr17:56585314 A/T cg05425664 chr17:57184151 TRIM37 0.49 6.77 0.38 8.43e-11 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04441191 chr3:48130393 MAP4 0.62 7.0 0.4 2.07e-11 Gut microbiome composition (summer); CESC cis rs722599 0.562 rs2193597 chr14:75234329 G/A cg08847533 chr14:75593920 NEK9 0.5 6.17 0.35 2.57e-9 IgG glycosylation; CESC cis rs453301 0.686 rs6601281 chr8:8911004 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -6.29 -0.36 1.31e-9 Joint mobility (Beighton score); CESC cis rs9916302 0.851 rs9904919 chr17:37556431 G/C cg07936489 chr17:37558343 FBXL20 0.79 11.49 0.58 4.71e-25 Glomerular filtration rate (creatinine); CESC cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.66 0.47 4.68e-16 Hip circumference adjusted for BMI; CESC cis rs61542988 0.535 rs10807813 chr7:22829961 C/T cg11367502 chr7:22862612 TOMM7 0.52 6.16 0.35 2.73e-9 Fibrinogen levels; CESC cis rs6732160 0.588 rs7578991 chr2:73376171 A/G cg01422370 chr2:73384389 NA 0.57 9.1 0.49 2.21e-17 Intelligence (multi-trait analysis); CESC trans rs722599 0.748 rs17102884 chr14:75374899 C/T cg00095594 chr1:236228625 NID1 -0.4 -6.17 -0.35 2.5e-9 IgG glycosylation; CESC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg00149659 chr3:10157352 C3orf10 0.74 9.04 0.49 3.31e-17 Alzheimer's disease; CESC cis rs7250872 0.647 rs2304613 chr19:1817943 G/C cg05970437 chr19:1864622 KLF16 0.47 5.49 0.32 9.4e-8 Bipolar disorder; CESC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.58 0.47 8.12e-16 Menopause (age at onset); CESC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg09359103 chr1:154839909 KCNN3 -0.7 -13.7 -0.64 1.12e-32 Prostate cancer; CESC trans rs8113263 1 rs8113263 chr19:13179662 C/A cg24196017 chr15:43021976 CDAN1 -0.76 -6.03 -0.35 5.61e-9 Body mass index; CESC cis rs4076764 1.000 rs4469696 chr1:163424565 C/T cg06092702 chr1:163392909 NA -0.37 -5.48 -0.32 9.9e-8 Motion sickness; CESC cis rs7818345 0.874 rs56298301 chr8:19305937 C/A cg11303988 chr8:19266685 CSGALNACT1 0.38 6.8 0.39 6.8e-11 Language performance in older adults (adjusted for episodic memory); CESC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg18110333 chr6:292329 DUSP22 -0.76 -10.27 -0.53 4.94e-21 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13150282 chr12:109531243 ALKBH2 -0.46 -6.1 -0.35 3.66e-9 Fibrinogen levels; CESC cis rs3820068 0.580 rs7512308 chr1:16006604 C/A cg17385448 chr1:15911702 AGMAT 0.39 6.02 0.35 5.82e-9 Systolic blood pressure; CESC cis rs9902453 1.000 rs28664971 chr17:28437410 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.78 0.47 2.02e-16 Coffee consumption (cups per day); CESC cis rs829661 0.947 rs829665 chr2:30724701 T/A cg12454169 chr2:30669597 LCLAT1 1.01 9.28 0.5 6.5e-18 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg21782813 chr7:2030301 MAD1L1 0.5 7.12 0.4 9.93e-12 Bipolar disorder and schizophrenia; CESC cis rs6502050 0.731 rs12150589 chr17:80158233 A/T cg23985595 chr17:80112537 CCDC57 -0.4 -6.37 -0.36 8.38e-10 Life satisfaction; CESC cis rs2559856 1.000 rs2695292 chr12:102087290 G/A cg15068132 chr12:102092402 CHPT1 -0.39 -5.18 -0.3 4.38e-7 Blood protein levels; CESC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg18769074 chr3:133464867 TF 0.31 5.87 0.34 1.31e-8 Iron status biomarkers; CESC cis rs5753618 0.561 rs9606831 chr22:31732512 C/T cg13145458 chr22:31556086 RNF185 -0.49 -5.51 -0.32 8.62e-8 Colorectal cancer; CESC cis rs16854884 0.657 rs34683397 chr3:143723559 C/T cg06585982 chr3:143692056 C3orf58 0.48 6.0 0.35 6.59e-9 Economic and political preferences (feminism/equality); CESC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.79 -0.55 9.74e-23 Alzheimer's disease; CESC cis rs9612 1.000 rs12669 chr19:44235535 G/A cg08581076 chr19:44259116 C19orf61 0.58 6.6 0.38 2.17e-10 Exhaled nitric oxide output; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19321118 chr6:26322387 NA -0.43 -6.14 -0.35 3.01e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg18402987 chr7:1209562 NA 0.43 5.54 0.32 7.32e-8 Longevity;Endometriosis; CESC cis rs6546550 0.901 rs6754896 chr2:70138170 T/C cg02498382 chr2:70120550 SNRNP27 -0.41 -7.26 -0.41 4.34e-12 Prevalent atrial fibrillation; CESC cis rs7107174 1.000 rs10899477 chr11:78052104 A/T cg02023728 chr11:77925099 USP35 0.47 6.25 0.36 1.63e-9 Testicular germ cell tumor; CESC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg10074409 chr1:209979377 IRF6 -0.37 -5.2 -0.3 4.05e-7 Cleft lip with or without cleft palate; CESC cis rs9611565 0.729 rs202654 chr22:41841034 G/A cg06634786 chr22:41940651 POLR3H 0.43 5.06 0.3 7.84e-7 Vitiligo; CESC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg27170947 chr2:26402098 FAM59B -0.59 -7.02 -0.4 1.84e-11 Gut microbiome composition (summer); CESC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg17376030 chr22:41985996 PMM1 -0.79 -8.37 -0.46 3.43e-15 Vitiligo; CESC cis rs9660992 0.674 rs12122105 chr1:205256818 C/T cg00857998 chr1:205179979 DSTYK 0.47 5.34 0.31 2.02e-7 Mean corpuscular volume;Mean platelet volume; CESC trans rs17508449 0.819 rs77042378 chr1:114209101 G/T cg04711050 chr9:4490757 SLC1A1 -0.66 -6.08 -0.35 4.19e-9 Leprosy; CESC cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg06636001 chr8:8085503 FLJ10661 0.51 6.35 0.36 9.5e-10 Mood instability; CESC cis rs4253772 0.614 rs11090859 chr22:46687460 T/G cg24881330 chr22:46731750 TRMU 0.86 9.19 0.49 1.19e-17 LDL cholesterol;Cholesterol, total; CESC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg05234568 chr11:5960015 NA -0.66 -9.96 -0.52 4.63e-20 DNA methylation (variation); CESC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg13206674 chr6:150067644 NUP43 0.41 5.6 0.33 5.42e-8 Lung cancer; CESC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.91e-10 Bipolar disorder; CESC cis rs597539 0.690 rs615644 chr11:68621806 G/C cg18350739 chr11:68623251 NA -0.45 -6.59 -0.38 2.34e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1620921 0.505 rs11756434 chr6:161201356 T/C cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs7208859 0.623 rs7208441 chr17:29143863 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.19 0.3 4.23e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4727027 0.835 rs6959224 chr7:148784495 A/G cg23583168 chr7:148888333 NA -0.66 -9.21 -0.49 1.04e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg02187348 chr16:89574699 SPG7 0.64 8.82 0.48 1.54e-16 Multiple myeloma (IgH translocation); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07998558 chr7:150648497 KCNH2 0.43 6.1 0.35 3.66e-9 Fibrinogen levels; CESC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg02725872 chr8:58115012 NA -0.34 -5.05 -0.3 8.26e-7 Developmental language disorder (linguistic errors); CESC cis rs1878931 0.696 rs35984213 chr16:3451030 G/A cg21433313 chr16:3507492 NAT15 -0.37 -5.37 -0.31 1.74e-7 Body mass index (adult); CESC cis rs7584330 0.554 rs116656801 chr2:238431257 A/G cg14458575 chr2:238380390 NA 0.48 5.24 0.31 3.29e-7 Prostate cancer; CESC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg04944784 chr2:26401820 FAM59B -0.66 -7.62 -0.42 4.62e-13 Gut microbiome composition (summer); CESC cis rs7845219 0.544 rs34293080 chr8:95908078 G/T cg13393036 chr8:95962371 TP53INP1 -0.44 -8.46 -0.46 1.89e-15 Type 2 diabetes; CESC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg14829155 chr15:31115871 NA -0.72 -9.65 -0.51 4.49e-19 Huntington's disease progression; CESC cis rs2710642 0.927 rs1468748 chr2:63204611 C/T cg17519650 chr2:63277830 OTX1 0.51 6.6 0.38 2.25e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg06481639 chr22:41940642 POLR3H -0.62 -6.32 -0.36 1.11e-9 Vitiligo; CESC cis rs2011503 0.843 rs2860494 chr19:19470426 T/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -5.04 -0.3 8.68e-7 Bipolar disorder; CESC cis rs1775715 0.678 rs2105360 chr10:32210198 C/T cg26784012 chr10:32216390 ARHGAP12 0.39 5.16 0.3 4.96e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg11941060 chr3:133502564 NA 0.48 6.68 0.38 1.42e-10 Iron status biomarkers; CESC cis rs7116495 1.000 rs4944232 chr11:71642258 A/G cg26138937 chr11:71823887 C11orf51 0.81 6.7 0.38 1.26e-10 Severe influenza A (H1N1) infection; CESC cis rs7481584 0.581 rs366422 chr11:3053873 C/T cg25174290 chr11:3078921 CARS -0.45 -6.34 -0.36 9.61e-10 Calcium levels; CESC cis rs7617773 0.817 rs9818937 chr3:48325281 G/A cg11946769 chr3:48343235 NME6 0.82 11.11 0.56 8.34e-24 Coronary artery disease; CESC cis rs9388451 0.874 rs3734634 chr6:126111800 G/A cg05901451 chr6:126070800 HEY2 -0.61 -8.63 -0.47 5.71e-16 Brugada syndrome; CESC cis rs13385 0.769 rs10060203 chr5:139599319 T/G cg26211634 chr5:139558579 C5orf32 0.46 5.12 0.3 5.97e-7 Atrial fibrillation; CESC cis rs5758659 0.967 rs5751250 chr22:42639645 T/G cg05082376 chr22:42548792 NA -0.36 -5.41 -0.32 1.39e-7 Cognitive function; CESC cis rs61931739 0.500 rs7313094 chr12:34457508 T/C cg23762105 chr12:34175262 ALG10 -0.41 -5.23 -0.31 3.42e-7 Morning vs. evening chronotype; CESC cis rs1707322 1.000 rs785498 chr1:46592414 C/T cg03146154 chr1:46216737 IPP -0.69 -9.1 -0.49 2.16e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs684232 0.602 rs10521107 chr17:511156 G/A cg12384639 chr17:618140 VPS53 0.44 5.55 0.32 6.92e-8 Prostate cancer; CESC cis rs6121246 0.821 rs6058448 chr20:30332396 C/T cg13852791 chr20:30311386 BCL2L1 0.82 8.74 0.47 2.63e-16 Mean corpuscular hemoglobin; CESC cis rs4727963 0.846 rs6466851 chr7:122699206 G/A cg03640110 chr7:122635026 TAS2R16 -0.37 -5.71 -0.33 3.07e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg24531977 chr5:56204891 C5orf35 -0.9 -12.15 -0.6 2.64e-27 Type 2 diabetes; CESC cis rs12543725 0.601 rs7018178 chr8:142239210 C/T cg23750338 chr8:142222470 SLC45A4 -0.37 -5.18 -0.3 4.36e-7 Birth weight; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01630199 chr7:66369076 NA -0.58 -6.25 -0.36 1.65e-9 Gut microbiome composition (summer); CESC cis rs55883249 1.000 rs11692112 chr2:9723732 G/T cg23886495 chr2:9695866 ADAM17 0.59 5.56 0.32 6.72e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs6987853 0.814 rs1947296 chr8:42452999 T/C cg09913449 chr8:42400586 C8orf40 0.43 7.1 0.4 1.12e-11 Mean corpuscular hemoglobin concentration; CESC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg11764359 chr7:65958608 NA 0.94 14.96 0.68 4.3e-37 Aortic root size; CESC cis rs763121 0.815 rs9306328 chr22:39028913 C/T cg06022373 chr22:39101656 GTPBP1 0.72 11.0 0.56 1.92e-23 Menopause (age at onset); CESC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs8141529 0.509 rs12628211 chr22:29239250 T/C cg15103426 chr22:29168792 CCDC117 0.62 8.07 0.44 2.48e-14 Lymphocyte counts; CESC cis rs263063 0.506 rs12611002 chr19:5051655 C/T cg18473234 chr19:5097819 KDM4B 0.64 5.07 0.3 7.6e-7 Periodontitis (CDC/AAP); CESC cis rs9314323 0.798 rs2019239 chr8:26217354 G/A cg13160058 chr8:26243215 BNIP3L -0.32 -5.15 -0.3 5.13e-7 Red cell distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00162751 chr1:220921532 MOSC2 -0.59 -7.28 -0.41 3.85e-12 Gut microbiome composition (summer); CESC cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg11752832 chr7:134001865 SLC35B4 0.55 7.23 0.41 5.27e-12 Mean platelet volume; CESC trans rs11098499 0.604 rs10022185 chr4:120571765 C/G cg25214090 chr10:38739885 LOC399744 0.6 7.88 0.44 8.29e-14 Corneal astigmatism; CESC cis rs1545257 0.538 rs729921 chr2:24633124 T/G cg06627628 chr2:24431161 ITSN2 -0.47 -5.71 -0.33 3.04e-8 Sjögren's syndrome; CESC cis rs6087990 0.735 rs2424920 chr20:31385452 T/C cg13636640 chr20:31349939 DNMT3B 0.8 12.87 0.62 8.95e-30 Ulcerative colitis; CESC cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.37 -6.42 -0.37 6.4e-10 Hemoglobin concentration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05994294 chr4:1374658 KIAA1530 -0.43 -6.03 -0.35 5.62e-9 Gut microbiota (bacterial taxa); CESC cis rs10242455 0.571 rs11734 chr7:99229768 C/G cg25640893 chr7:99214727 ZNF498 -0.8 -6.35 -0.36 9.2e-10 Blood metabolite levels; CESC cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.14 0.3 5.45e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12824058 0.831 rs11616174 chr12:130814503 A/G cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs6693567 0.565 rs834235 chr1:150362154 C/T cg09579323 chr1:150459698 TARS2 0.48 6.03 0.35 5.58e-9 Migraine; CESC cis rs3105593 0.555 rs3098169 chr15:50754339 G/A cg05456662 chr15:50716270 USP8 0.39 5.19 0.3 4.22e-7 QT interval; CESC cis rs6088590 0.561 rs2295444 chr20:33173883 C/T cg06115741 chr20:33292138 TP53INP2 0.51 6.53 0.37 3.27e-10 Coronary artery disease; CESC cis rs12042052 1.000 rs10910623 chr1:232938699 G/A cg00951395 chr1:232941775 KIAA1383 0.57 5.65 0.33 4.16e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs9611565 0.546 rs132793 chr22:42063681 A/G cg03806693 chr22:41940476 POLR3H 1.06 11.79 0.59 4.4e-26 Vitiligo; CESC cis rs6502050 0.835 rs7209474 chr17:80136418 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.2 -0.3 3.89e-7 Life satisfaction; CESC trans rs61931739 0.500 rs10844863 chr12:34532284 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 8.03e-13 Morning vs. evening chronotype; CESC cis rs11711311 0.712 rs10804510 chr3:113340700 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.27 0.36 1.43e-9 IgG glycosylation; CESC cis rs10751667 0.666 rs10794347 chr11:939863 G/A cg20946044 chr11:1010712 AP2A2 -0.39 -5.44 -0.32 1.23e-7 Alzheimer's disease (late onset); CESC cis rs1008375 1.000 rs2058338 chr4:17678600 A/G cg16339924 chr4:17578868 LAP3 -0.5 -6.37 -0.36 8.11e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6088580 0.619 rs1205335 chr20:32927507 C/T cg24642439 chr20:33292090 TP53INP2 -0.52 -6.77 -0.38 8.14e-11 Glomerular filtration rate (creatinine); CESC cis rs1707322 0.963 rs12076580 chr1:46258159 G/A cg06784218 chr1:46089804 CCDC17 0.37 6.37 0.36 8.49e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg06808227 chr14:105710500 BRF1 -0.53 -5.9 -0.34 1.08e-8 Mean platelet volume;Platelet distribution width; CESC cis rs5758511 0.680 rs5758667 chr22:42633204 G/A cg00645731 chr22:42541494 CYP2D7P1 0.56 8.32 0.46 4.6e-15 Birth weight; CESC cis rs4948102 0.686 rs7801467 chr7:56160977 A/G cg09872392 chr7:56161020 PHKG1 -0.47 -7.44 -0.42 1.45e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs2415984 0.622 rs17672908 chr14:46934527 T/C cg14871534 chr14:47121158 RPL10L -0.35 -5.31 -0.31 2.37e-7 Number of children ever born; CESC cis rs561341 1.000 rs15654 chr17:30326360 A/C cg12193833 chr17:30244370 NA -0.72 -6.68 -0.38 1.42e-10 Hip circumference adjusted for BMI; CESC cis rs1371867 0.846 rs2919471 chr8:101232701 T/C cg11906718 chr8:101322791 RNF19A -0.5 -6.19 -0.36 2.22e-9 Atrioventricular conduction; CESC cis rs933688 1.000 rs12656350 chr5:90751343 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.1 12.55 0.61 1.13e-28 Smoking behavior; CESC cis rs921968 0.541 rs7603816 chr2:219396255 C/T cg02176678 chr2:219576539 TTLL4 -0.54 -9.78 -0.51 1.78e-19 Mean corpuscular hemoglobin concentration; CESC trans rs11098499 0.909 rs1809406 chr4:120377122 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.91 0.52 6.89e-20 Corneal astigmatism; CESC cis rs208515 0.525 rs4145045 chr6:66678949 T/C cg07460842 chr6:66804631 NA 0.85 10.63 0.55 3.24e-22 Exhaled nitric oxide levels; CESC cis rs7208859 0.623 rs3794796 chr17:29130880 G/C cg19761014 chr17:28927070 LRRC37B2 0.78 6.23 0.36 1.81e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16866257 chr17:61905183 FTSJ3;PSMC5 -0.46 -6.6 -0.38 2.25e-10 Gambling; CESC cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg06453172 chr10:134556979 INPP5A -0.38 -5.09 -0.3 6.89e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs56104184 0.723 rs1058483 chr19:49407660 G/A cg21252483 chr19:49399788 TULP2 -0.52 -5.68 -0.33 3.59e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.38 -6.14 -0.35 2.97e-9 Cystic fibrosis severity; CESC cis rs2479724 0.935 rs2254936 chr6:41846569 A/G cg08135965 chr6:41755394 TOMM6 0.39 5.43 0.32 1.26e-7 Menarche (age at onset); CESC cis rs2625529 0.652 rs12148078 chr15:72300471 G/C cg16672083 chr15:72433130 SENP8 0.42 6.39 0.37 7.32e-10 Red blood cell count; CESC cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg18351406 chr4:77819688 ANKRD56 0.53 6.57 0.37 2.68e-10 Emphysema distribution in smoking; CESC cis rs1018836 0.892 rs4735224 chr8:91567046 C/A cg16814680 chr8:91681699 NA -0.6 -8.37 -0.46 3.34e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9911578 1.000 rs7216680 chr17:56988243 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.05 0.3 8.3e-7 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12532653 chr5:140090559 VTRNA1-1 0.42 6.86 0.39 4.75e-11 Gambling; CESC cis rs854765 0.583 rs8065970 chr17:17858771 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs12618769 0.597 rs72821951 chr2:99157009 A/C cg10123293 chr2:99228465 UNC50 0.4 5.23 0.31 3.4e-7 Bipolar disorder; CESC cis rs10911232 0.526 rs41475048 chr1:183058452 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.58 -6.29 -0.36 1.33e-9 Hypertriglyceridemia; CESC cis rs763014 0.931 rs10903017 chr16:627920 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.13 -0.3 5.63e-7 Height; CESC cis rs11630290 0.736 rs28621516 chr15:64156314 G/A cg12036633 chr15:63758958 NA -0.52 -5.29 -0.31 2.5e-7 Iris characteristics; CESC cis rs6499255 1.000 rs6499253 chr16:69802672 C/T cg15192750 chr16:69999425 NA 0.46 5.63 0.33 4.55e-8 IgE levels; CESC cis rs5750830 0.594 rs5757647 chr22:39775047 C/A cg11247378 chr22:39784982 NA -0.51 -7.72 -0.43 2.36e-13 Intelligence (multi-trait analysis); CESC cis rs9640161 0.871 rs56156367 chr7:150047201 A/T cg17279839 chr7:150038598 RARRES2 0.49 5.9 0.34 1.13e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs2439831 1.000 rs2467740 chr15:43746792 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.82 11.97 0.59 1.11e-26 Lung cancer in ever smokers; CESC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg23131131 chr22:24373011 LOC391322 -0.69 -9.51 -0.5 1.23e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4319547 0.956 rs9988963 chr12:122991478 C/G cg05707623 chr12:122985044 ZCCHC8 -0.58 -6.76 -0.38 8.92e-11 Body mass index; CESC cis rs75887402 1.000 rs7726814 chr5:122725497 A/G cg27033705 chr5:122759302 CEP120 0.86 6.49 0.37 4.32e-10 Breast cancer; CESC cis rs698833 0.892 rs786418 chr2:44688413 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.88 0.34 1.21e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7762018 0.891 rs4716343 chr6:170143817 C/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.65 6.46 0.37 5e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs55794721 0.509 rs2375313 chr1:25748235 G/A cg27572855 chr1:25598939 RHD 0.49 8.35 0.46 3.85e-15 Plateletcrit;Mean corpuscular volume; CESC cis rs6424115 0.692 rs573361 chr1:24053674 A/T cg10978503 chr1:24200527 CNR2 0.27 5.35 0.31 1.94e-7 Immature fraction of reticulocytes; CESC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.17e-9 Menopause (age at onset); CESC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.62 -0.33 4.89e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg01341218 chr17:43662625 NA 0.56 7.51 0.42 9.22e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs651907 0.557 rs36002990 chr3:101437862 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.88 0.34 1.22e-8 Colorectal cancer; CESC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg13206674 chr6:150067644 NUP43 0.42 5.85 0.34 1.47e-8 Lung cancer; CESC cis rs763121 0.853 rs5750622 chr22:38956464 C/G cg06022373 chr22:39101656 GTPBP1 0.83 12.01 0.59 8.36e-27 Menopause (age at onset); CESC cis rs3762637 1.000 rs3762637 chr3:122145324 C/T cg24169773 chr3:122142474 KPNA1 -0.56 -6.65 -0.38 1.68e-10 LDL cholesterol levels; CESC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg20151795 chr6:28129481 ZNF389 -0.39 -5.08 -0.3 7.23e-7 Depression; CESC cis rs2273669 0.667 rs76367548 chr6:109356589 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs10789491 0.767 rs4660359 chr1:47190019 C/G cg15501359 chr1:47185051 KIAA0494 0.67 6.62 0.38 2e-10 Response to hepatitis C treatment; CESC cis rs7084402 0.565 rs11006187 chr10:60333383 A/G cg07615347 chr10:60278583 BICC1 -0.41 -6.0 -0.35 6.44e-9 Refractive error; CESC cis rs2625529 0.627 rs1037680 chr15:72514319 T/C cg16672083 chr15:72433130 SENP8 -0.41 -5.41 -0.32 1.38e-7 Red blood cell count; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg08307039 chr5:64920116 TRIM23;C5orf44 0.44 6.19 0.36 2.34e-9 Positive affect; CESC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.73 -0.33 2.73e-8 Total body bone mineral density; CESC cis rs3820068 0.603 rs41270279 chr1:15988878 A/G cg18133145 chr1:16060689 PLEKHM2 -0.39 -5.04 -0.3 8.55e-7 Systolic blood pressure; CESC cis rs4718428 0.672 rs13241598 chr7:66300652 A/G cg12165864 chr7:66369176 NA -0.63 -7.14 -0.4 8.84e-12 Corneal structure; CESC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg18252515 chr7:66147081 NA 0.44 5.7 0.33 3.18e-8 Aortic root size; CESC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.26 0.36 1.52e-9 Bipolar disorder; CESC cis rs919433 0.927 rs6759834 chr2:198204860 C/T cg03934865 chr2:198174659 NA -0.41 -5.52 -0.32 8.25e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs9733 0.688 rs12725667 chr1:150766070 A/T cg13175981 chr1:150552382 MCL1 0.52 7.24 0.41 4.84e-12 Tonsillectomy; CESC trans rs2571521 0.887 rs9298879 chr9:26097224 A/C cg21041764 chr15:49103369 CEP152 0.74 6.09 0.35 3.96e-9 Pursuit maintenance gain in psychotic disorders; CESC cis rs710216 0.843 rs3768043 chr1:43419354 C/A cg03128534 chr1:43423976 SLC2A1 -0.6 -7.66 -0.43 3.55e-13 Red cell distribution width; CESC cis rs2120019 1.000 rs12898259 chr15:75369780 G/A cg09165964 chr15:75287851 SCAMP5 -0.67 -8.12 -0.45 1.76e-14 Blood trace element (Zn levels); CESC cis rs7818688 0.697 rs11784212 chr8:95976995 G/A cg16049864 chr8:95962084 TP53INP1 0.57 5.73 0.33 2.79e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs17376456 0.825 rs17372057 chr5:93071916 C/A cg21475434 chr5:93447410 FAM172A 0.79 7.22 0.41 5.39e-12 Diabetic retinopathy; CESC cis rs2066819 1.000 rs2695789 chr12:56694261 C/A cg26734620 chr12:56694298 CS -0.93 -9.55 -0.51 9.4e-19 Psoriasis vulgaris; CESC cis rs7662987 0.517 rs2924580 chr4:100032168 C/G cg13256891 chr4:100009986 ADH5 0.77 8.45 0.46 1.95e-15 Smoking initiation; CESC cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg10057126 chr4:77819792 ANKRD56 0.61 8.78 0.47 2.1e-16 Emphysema distribution in smoking; CESC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg11764359 chr7:65958608 NA 0.78 9.28 0.5 6.36e-18 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00385906 chr1:117910225 MAN1A2 0.57 7.21 0.4 5.92e-12 Gut microbiome composition (summer); CESC cis rs721399 0.553 rs13262341 chr8:18243097 A/G cg18736775 chr8:18248649 NAT2 -0.53 -5.52 -0.32 8.18e-8 Blood metabolite levels; CESC cis rs6456156 0.524 rs6932740 chr6:167466439 G/A cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.13e-10 Primary biliary cholangitis; CESC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg11890956 chr21:40555474 PSMG1 1.17 21.83 0.8 3.83e-61 Cognitive function; CESC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg22903657 chr4:1355424 KIAA1530 -0.38 -5.18 -0.3 4.5e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02330494 chr15:41786605 ITPKA 0.62 7.14 0.4 8.78e-12 Gut microbiome composition (summer); CESC cis rs17125944 0.505 rs2274275 chr14:53235728 G/T cg00686598 chr14:53173677 PSMC6 1.42 11.99 0.59 9.42e-27 Alzheimer's disease (late onset); CESC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg18252515 chr7:66147081 NA 0.39 5.2 0.3 4.09e-7 Aortic root size; CESC cis rs11249608 0.548 rs7704565 chr5:178473923 G/C cg01312482 chr5:178451176 ZNF879 -0.44 -5.82 -0.34 1.73e-8 Pubertal anthropometrics; CESC cis rs7937682 0.924 rs10891284 chr11:111527737 T/C cg09085632 chr11:111637200 PPP2R1B -1.0 -16.56 -0.71 9.02e-43 Primary sclerosing cholangitis; CESC cis rs3015469 0.671 rs61985508 chr14:51218537 G/A cg26011998 chr14:51135199 SAV1 0.52 5.74 0.33 2.63e-8 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs6964587 0.967 rs41371748 chr7:91708219 A/G cg17063962 chr7:91808500 NA 0.53 6.2 0.36 2.12e-9 Breast cancer; CESC cis rs6693295 0.877 rs12065115 chr1:246296690 A/T cg11798871 chr1:246315928 SMYD3 0.4 5.26 0.31 2.92e-7 Migraine - clinic-based;Migraine with aura; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10451977 chr15:45507901 NA 0.5 6.11 0.35 3.52e-9 Ulcerative colitis; CESC cis rs6088580 0.634 rs6059892 chr20:33105766 A/G cg24642439 chr20:33292090 TP53INP2 0.51 6.62 0.38 1.99e-10 Glomerular filtration rate (creatinine); CESC cis rs2066819 1.000 rs58852079 chr12:56706922 A/C cg26734620 chr12:56694298 CS 1.03 6.25 0.36 1.65e-9 Psoriasis vulgaris; CESC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg11890956 chr21:40555474 PSMG1 -0.68 -9.57 -0.51 7.95e-19 Menarche (age at onset); CESC trans rs10411161 0.702 rs6509591 chr19:52391940 A/T cg22319618 chr22:45562946 NUP50 -0.58 -6.09 -0.35 3.97e-9 Breast cancer; CESC cis rs9858542 0.903 rs11917431 chr3:49644012 C/T cg03060546 chr3:49711283 APEH -0.54 -6.36 -0.36 8.92e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9039 1.000 rs11862745 chr16:9218887 C/T cg08831531 chr16:9218945 NA 0.43 6.19 0.36 2.22e-9 Menopause (age at onset); CESC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg08859206 chr1:53392774 SCP2 -0.63 -8.71 -0.47 3.43e-16 Monocyte count; CESC cis rs7208859 0.623 rs56812022 chr17:29068733 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.33 0.36 1.04e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg12311346 chr5:56204834 C5orf35 0.64 8.79 0.48 1.95e-16 Initial pursuit acceleration; CESC cis rs1348850 0.561 rs4893956 chr2:178373452 C/T cg23306229 chr2:178417860 TTC30B 0.8 7.39 0.41 1.96e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11587400 0.532 rs2268700 chr1:115228879 T/G cg12756093 chr1:115239321 AMPD1 -0.52 -7.35 -0.41 2.45e-12 Autism; CESC cis rs72781680 0.898 rs72798064 chr2:23982832 T/C cg08917208 chr2:24149416 ATAD2B 0.96 8.7 0.47 3.55e-16 Lymphocyte counts; CESC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg27125505 chr17:43679177 LOC644172 0.46 6.2 0.36 2.11e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3096299 0.933 rs2965938 chr16:89491336 C/T cg16743903 chr16:89593216 SPG7 -0.42 -5.46 -0.32 1.1e-7 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02250680 chr11:58346542 LPXN;ZFP91-CNTF;ZFP91 0.58 6.67 0.38 1.53e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08855361 chr16:58718334 SLC38A7 0.6 6.78 0.38 7.69e-11 Gut microbiome composition (summer); CESC cis rs62064224 0.533 rs11657826 chr17:30790386 T/A cg12855166 chr17:30846586 MYO1D 0.4 5.18 0.3 4.31e-7 Schizophrenia; CESC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg25072359 chr17:41440525 NA 0.44 6.07 0.35 4.52e-9 Menopause (age at onset); CESC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg08888203 chr3:10149979 C3orf24 0.45 5.91 0.34 1.06e-8 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14559409 chr10:65930703 NA 0.45 6.39 0.37 7.53e-10 Fibrinogen levels; CESC cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg14829155 chr15:31115871 NA -0.73 -9.66 -0.51 4.04e-19 Huntington's disease progression; CESC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg19163074 chr7:65112434 INTS4L2 -0.46 -5.05 -0.3 8.07e-7 Aortic root size; CESC cis rs73206853 0.764 rs60339427 chr12:110824471 G/A cg12870014 chr12:110450643 ANKRD13A 0.63 5.23 0.31 3.48e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg18404041 chr3:52824283 ITIH1 -0.34 -6.02 -0.35 5.72e-9 Bipolar disorder; CESC cis rs7786808 0.707 rs62479983 chr7:158227613 G/A cg09998033 chr7:158218633 PTPRN2 -0.44 -6.53 -0.37 3.39e-10 Obesity-related traits; CESC cis rs9291683 0.588 rs3756237 chr4:10013378 G/A cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.7e-37 Bone mineral density; CESC cis rs2603127 0.768 rs6789985 chr3:108480476 G/A cg03329597 chr3:108125523 MYH15 0.6 5.35 0.31 1.91e-7 Hemostatic factors and hematological phenotypes; CESC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.92 8.92 0.48 8e-17 Platelet count; CESC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg18404041 chr3:52824283 ITIH1 0.37 6.12 0.35 3.33e-9 Bipolar disorder; CESC cis rs2228479 0.618 rs17233623 chr16:89811209 C/T cg04013166 chr16:89971882 TCF25 0.75 7.4 0.41 1.86e-12 Skin colour saturation; CESC cis rs634534 0.562 rs1151505 chr11:65734539 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 6.44 0.37 5.64e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs734999 0.566 rs10752747 chr1:2524915 G/T cg20673091 chr1:2541236 MMEL1 0.43 6.9 0.39 3.84e-11 Ulcerative colitis; CESC cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.36 0.6 5.16e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6087990 0.735 rs6058891 chr20:31386347 T/C cg13636640 chr20:31349939 DNMT3B 0.79 12.85 0.62 1.1e-29 Ulcerative colitis; CESC cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg14582100 chr15:45693742 SPATA5L1 0.43 6.2 0.36 2.17e-9 Homoarginine levels; CESC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg18032046 chr6:28092343 ZSCAN16 0.47 5.56 0.32 6.44e-8 Depression; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04458869 chr2:169312687 LASS6 -0.45 -6.21 -0.36 2e-9 Asthma; CESC trans rs12991495 0.531 rs11686210 chr2:25433366 A/G cg19377421 chr1:156697041 ISG20L2;C1orf66 0.49 6.02 0.35 5.76e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in smokers;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg13298116 chr11:62369859 EML3;MTA2 0.61 9.11 0.49 2.05e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7772486 0.686 rs1415744 chr6:146022531 C/T cg23711669 chr6:146136114 FBXO30 0.89 12.86 0.62 9.66e-30 Lobe attachment (rater-scored or self-reported); CESC trans rs7716219 0.731 rs7704138 chr5:54944262 C/T cg18226868 chr15:50646438 GABPB1;FLJ10038;LOC100129387 -0.43 -6.01 -0.35 6.12e-9 Height; CESC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg25405998 chr7:65216604 CCT6P1 -0.45 -5.06 -0.3 7.71e-7 Aortic root size; CESC cis rs929354 0.772 rs3802124 chr7:156970609 G/A cg05182265 chr7:156933206 UBE3C -0.5 -7.3 -0.41 3.28e-12 Body mass index; CESC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg06481639 chr22:41940642 POLR3H -0.62 -6.47 -0.37 4.82e-10 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10957584 chr16:5148097 FAM86A -0.57 -6.39 -0.37 7.44e-10 Gut microbiome composition (summer); CESC cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg02551604 chr5:131831745 NA -0.37 -5.27 -0.31 2.81e-7 Asthma (sex interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20798677 chr17:39968547 FKBP10;SC65 0.6 6.48 0.37 4.39e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19410790 chr1:112282146 C1orf183 0.6 6.63 0.38 1.87e-10 Gut microbiome composition (summer); CESC cis rs787274 0.850 rs10739378 chr9:115639631 C/T cg13803584 chr9:115635662 SNX30 -0.7 -5.43 -0.32 1.26e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs240764 0.764 rs2213594 chr6:100931400 G/A cg21058520 chr6:100914733 NA 0.39 6.18 0.36 2.37e-9 Neuroticism; CESC cis rs7590720 1.000 rs7592663 chr2:216894978 T/C cg12620499 chr2:216877984 MREG 0.88 12.19 0.6 2.02e-27 Alcohol dependence; CESC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg17509989 chr5:176798049 RGS14 0.48 5.78 0.33 2.12e-8 Hemoglobin concentration;Hematocrit; CESC cis rs9457247 0.967 rs387733 chr6:167409771 C/T cg23791538 chr6:167370224 RNASET2 0.61 8.61 0.47 6.74e-16 Crohn's disease; CESC cis rs6032067 0.586 rs13044116 chr20:43754444 T/C cg10761708 chr20:43804764 PI3 0.49 5.16 0.3 4.81e-7 Blood protein levels; CESC cis rs12200560 0.505 rs211182 chr6:97074513 G/A cg06623918 chr6:96969491 KIAA0776 0.51 6.55 0.37 2.93e-10 Coronary heart disease; CESC cis rs4919087 1.000 rs4919089 chr10:99087905 G/A cg25902810 chr10:99078978 FRAT1 -0.66 -8.61 -0.47 6.57e-16 Monocyte count; CESC trans rs35110281 0.805 rs2838318 chr21:44991825 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.46 6.18 0.35 2.4e-9 Mean corpuscular volume; CESC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg22143856 chr6:28129313 ZNF389 0.42 5.26 0.31 2.91e-7 Parkinson's disease; CESC cis rs8060686 0.641 rs79719939 chr16:68240216 A/G cg26727032 chr16:67993705 SLC12A4 -0.53 -5.95 -0.34 8.65e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg05863683 chr7:1912471 MAD1L1 0.38 5.71 0.33 3.07e-8 Bipolar disorder and schizophrenia; CESC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.4 0.5 2.72e-18 Menopause (age at onset); CESC cis rs3026101 0.671 rs57774467 chr17:5300205 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs67460515 0.563 rs6772723 chr3:160895074 C/G cg03342759 chr3:160939853 NMD3 -0.55 -7.4 -0.41 1.76e-12 Parkinson's disease; CESC cis rs2302190 0.882 rs3809709 chr17:56590559 C/T cg25885038 chr17:56607967 SEPT4 -0.42 -5.7 -0.33 3.22e-8 Vitamin D levels; CESC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg00166722 chr3:10149974 C3orf24 0.49 6.04 0.35 5.3e-9 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16841327 chr22:46466183 NA -0.48 -6.42 -0.37 6.32e-10 Fibrinogen levels; CESC cis rs6570726 0.764 rs4896821 chr6:145896181 G/A cg23711669 chr6:146136114 FBXO30 0.83 12.51 0.61 1.62e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs12545109 0.679 rs1973628 chr8:57429360 T/C cg09654669 chr8:57350985 NA -0.61 -6.56 -0.37 2.88e-10 Obesity-related traits; CESC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10415122 chr15:75981489 CSPG4 -0.5 -6.08 -0.35 4.19e-9 Gut microbiome composition (summer); CESC cis rs1707322 0.721 rs6429574 chr1:46134054 A/G cg05343316 chr1:45956843 TESK2 0.49 6.21 0.36 2e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs116095464 0.764 rs10069197 chr5:230822 G/C cg22857025 chr5:266934 NA -1.28 -18.8 -0.76 1.06e-50 Breast cancer; CESC cis rs9486719 1.000 rs12529248 chr6:96895377 T/G cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs6496667 0.779 rs7163632 chr15:91039020 C/T cg13834112 chr15:90361639 NA 0.4 5.37 0.31 1.71e-7 Rheumatoid arthritis; CESC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -10.93 -0.56 3.43e-23 Extrinsic epigenetic age acceleration; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg01337508 chr17:40540572 STAT3 0.48 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs2933343 1.000 rs789232 chr3:128603080 T/G cg25356066 chr3:128598488 ACAD9 0.6 7.48 0.42 1.09e-12 IgG glycosylation; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12508534 chr6:34855789 TAF11;ANKS1A -0.47 -6.1 -0.35 3.72e-9 Ulcerative colitis; CESC cis rs6430585 0.528 rs3112496 chr2:136711064 C/T cg07169764 chr2:136633963 MCM6 1.08 15.17 0.68 7.79e-38 Corneal structure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21412001 chr3:47517510 SCAP 0.51 6.09 0.35 4.06e-9 Gut microbiome composition (summer); CESC cis rs10838687 0.867 rs2633082 chr11:47248050 C/G cg25783544 chr11:47291846 MADD -0.59 -7.41 -0.41 1.66e-12 Proinsulin levels; CESC cis rs7772486 0.875 rs10457796 chr6:146416087 T/G cg05347473 chr6:146136440 FBXO30 0.48 6.51 0.37 3.83e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg11644478 chr21:40555479 PSMG1 1.01 16.12 0.7 3.2e-41 Cognitive function; CESC cis rs425277 0.583 rs3128334 chr1:2038662 G/A cg12718519 chr1:2058417 PRKCZ -0.24 -5.07 -0.3 7.6e-7 Height; CESC cis rs6867032 0.958 rs9312970 chr5:2002415 C/A cg26168224 chr5:2018326 NA -0.83 -13.46 -0.64 8.33e-32 Gut microbiome composition (winter); CESC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg17724175 chr1:150552817 MCL1 0.4 6.28 0.36 1.42e-9 Melanoma; CESC cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.89 0.48 9.9900000000000006e-17 Colonoscopy-negative controls vs population controls; CESC cis rs67311347 1.000 rs7628796 chr3:40507332 G/A cg09455208 chr3:40491958 NA -0.48 -8.31 -0.45 5.16e-15 Renal cell carcinoma; CESC cis rs1005277 0.505 rs1208689 chr10:38097775 C/G cg25427524 chr10:38739819 LOC399744 -0.68 -10.07 -0.53 2.1e-20 Extrinsic epigenetic age acceleration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12129103 chr5:134369903 PITX1 -0.5 -7.37 -0.41 2.2e-12 Gambling; CESC cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg13902645 chr11:5959945 NA -0.56 -7.14 -0.4 9.07e-12 DNA methylation (variation); CESC trans rs877282 0.947 rs12358875 chr10:757531 T/C cg22713356 chr15:30763199 NA 1.05 9.16 0.49 1.45e-17 Uric acid levels; CESC cis rs4481233 0.528 rs115776655 chr4:10381329 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -6.12 -0.35 3.33e-9 Metabolic traits; CESC cis rs6540556 0.906 rs6540554 chr1:209932297 A/T cg05527609 chr1:210001259 C1orf107 0.44 5.77 0.33 2.17e-8 Red blood cell count; CESC cis rs17666538 0.535 rs168062 chr8:632444 T/A cg02524346 chr8:600233 NA 0.8 6.05 0.35 4.91e-9 IgG glycosylation; CESC cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.18 0.3 4.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.898 rs72782138 chr2:24048162 T/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs4835473 0.932 rs4287958 chr4:144908872 T/C cg25736465 chr4:144833511 NA 0.42 6.43 0.37 6.02e-10 Immature fraction of reticulocytes; CESC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.48 0.61 1.96e-28 Personality dimensions; CESC cis rs67478160 0.643 rs11628332 chr14:104241141 C/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.49 0.54 9.33e-22 Schizophrenia; CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.42 -5.32 -0.31 2.17e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs798554 0.616 rs1636252 chr7:2884993 A/C cg04166393 chr7:2884313 GNA12 0.43 5.61 0.33 5.09e-8 Height; CESC cis rs2652822 0.935 rs7162825 chr15:63439186 A/G cg02713581 chr15:63449717 RPS27L -0.54 -6.98 -0.39 2.32e-11 Metabolic traits; CESC cis rs7772486 0.682 rs1337840 chr6:146042558 T/C cg05347473 chr6:146136440 FBXO30 -0.48 -6.45 -0.37 5.16e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9814567 1.000 rs13087875 chr3:134261123 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2228479 0.702 rs3819574 chr16:89826630 G/A cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.26e-11 Skin colour saturation; CESC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.18 0.53 9.01e-21 Mean platelet volume; CESC cis rs8067354 0.574 rs2526354 chr17:57976658 A/G cg02344993 chr17:57696989 CLTC 0.5 5.34 0.31 1.96e-7 Hemoglobin concentration; CESC cis rs12464559 0.649 rs3768658 chr2:152677674 T/C cg01189475 chr2:152685088 ARL5A 0.66 5.81 0.34 1.74e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs742320 0.756 rs3765263 chr16:840378 A/G cg03433313 chr16:819064 MIR662 -0.44 -5.86 -0.34 1.34e-8 Mean corpuscular volume; CESC cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg13114125 chr14:105738426 BRF1 -0.83 -10.59 -0.55 4.35e-22 Mean platelet volume;Platelet distribution width; CESC cis rs12986413 0.624 rs12460763 chr19:2138507 A/G cg09261902 chr19:2140048 AP3D1 0.34 5.44 0.32 1.24e-7 Height; CESC cis rs698833 0.548 rs6721421 chr2:44535686 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.52 5.29 0.31 2.55e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs6831352 0.691 rs2602887 chr4:100041473 A/G cg12011299 chr4:100065546 ADH4 0.57 6.14 0.35 3.08e-9 Alcohol dependence; CESC cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg02297831 chr4:17616191 MED28 0.44 5.4 0.32 1.45e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs79349575 0.811 rs60708039 chr17:46999373 C/G cg16584676 chr17:46985605 UBE2Z 0.54 6.7 0.38 1.24e-10 Type 2 diabetes; CESC cis rs67311347 0.866 rs3214006 chr3:40352134 C/T cg24209194 chr3:40518798 ZNF619 0.41 5.16 0.3 4.89e-7 Renal cell carcinoma; CESC trans rs8017423 1.000 rs4900028 chr14:90685594 C/T cg01911440 chr17:78818045 RPTOR -0.4 -6.01 -0.35 6.24e-9 Mortality in heart failure; CESC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.55 -0.32 6.96e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs863345 0.604 rs10908654 chr1:158455790 A/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.14 -0.4 8.77e-12 Pneumococcal bacteremia; CESC cis rs6163 0.588 rs67506723 chr10:104509064 G/T cg04362960 chr10:104952993 NT5C2 0.41 5.58 0.32 5.9e-8 Waist circumference;Hip circumference; CESC cis rs1707322 0.685 rs11211177 chr1:46226349 A/G cg06784218 chr1:46089804 CCDC17 0.37 6.55 0.37 2.99e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg23048001 chr7:2026167 MAD1L1 0.43 5.58 0.32 6.09e-8 Bipolar disorder and schizophrenia; CESC cis rs6752107 0.782 rs12692254 chr2:234161211 A/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 6.74 0.38 9.59e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs1351164 0.591 rs9752576 chr2:218269445 G/A cg15335768 chr2:218268053 DIRC3 -0.35 -5.11 -0.3 6.24e-7 Height; CESC cis rs9787249 0.957 rs11809515 chr1:40205326 C/A cg24920358 chr1:40204285 PPIE 0.43 6.47 0.37 4.72e-10 Blood protein levels; CESC cis rs16866061 0.926 rs1523919 chr2:225403615 G/A cg12698349 chr2:225449008 CUL3 0.75 10.61 0.55 3.82e-22 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC trans rs561341 1.000 rs483301 chr17:30293398 G/T cg27661571 chr11:113659931 NA -0.87 -8.06 -0.44 2.57e-14 Hip circumference adjusted for BMI; CESC cis rs16854884 0.789 rs34096668 chr3:143794483 C/T cg06585982 chr3:143692056 C3orf58 0.43 5.29 0.31 2.63e-7 Economic and political preferences (feminism/equality); CESC cis rs698813 0.604 rs768007 chr2:44487486 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 5.68 0.33 3.49e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg17143192 chr8:8559678 CLDN23 0.73 8.7 0.47 3.69e-16 Obesity-related traits; CESC cis rs2742234 0.590 rs2115817 chr10:43686552 C/T cg15436174 chr10:43711423 RASGEF1A -0.5 -5.84 -0.34 1.5e-8 Hirschsprung disease; CESC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg24562669 chr7:97807699 LMTK2 0.52 7.41 0.41 1.66e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg06028605 chr16:24865363 SLC5A11 0.53 7.24 0.41 4.83e-12 Intelligence (multi-trait analysis); CESC cis rs4555082 1.000 rs7146012 chr14:105757566 G/A cg27165867 chr14:105738592 BRF1 -0.45 -5.1 -0.3 6.61e-7 Mean platelet volume;Platelet distribution width; CESC cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg15782153 chr7:917662 C7orf20 0.49 7.07 0.4 1.39e-11 Perceived unattractiveness to mosquitoes; CESC trans rs800888 0.772 rs13271228 chr8:116597409 A/C cg19047077 chr12:105044897 CHST11 -0.47 -6.1 -0.35 3.84e-9 Monocyte percentage of white cells; CESC cis rs763121 0.819 rs5757160 chr22:38989646 T/C cg21395723 chr22:39101663 GTPBP1 0.51 6.82 0.39 6.01e-11 Menopause (age at onset); CESC cis rs4919087 0.962 rs3740522 chr10:99019144 C/T cg25902810 chr10:99078978 FRAT1 0.68 9.9 0.52 7.23e-20 Monocyte count; CESC cis rs1448094 0.717 rs7305873 chr12:86290831 G/C cg02569458 chr12:86230093 RASSF9 0.38 5.49 0.32 9.45e-8 Major depressive disorder; CESC cis rs7084402 0.967 rs1658425 chr10:60331547 G/C cg07615347 chr10:60278583 BICC1 0.57 8.46 0.46 1.84e-15 Refractive error; CESC cis rs2280018 1.000 rs2280017 chr16:15151361 A/G cg27102117 chr16:15229624 NA -0.47 -7.37 -0.41 2.14e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg23711669 chr6:146136114 FBXO30 1.01 15.52 0.69 4.59e-39 Lobe attachment (rater-scored or self-reported); CESC trans rs1728785 0.901 rs1728797 chr16:68570989 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.44 0.42 1.41e-12 Ulcerative colitis; CESC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.95 0.39 2.86e-11 Electroencephalogram traits; CESC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 7.41 0.41 1.72e-12 Total body bone mineral density; CESC cis rs9611565 0.765 rs202663 chr22:41812819 T/C cg17376030 chr22:41985996 PMM1 -0.59 -6.28 -0.36 1.4e-9 Vitiligo; CESC trans rs17764205 0.777 rs113305163 chr19:3252194 G/C cg22364819 chr2:127864926 BIN1 0.73 6.02 0.35 5.75e-9 Bipolar disorder and schizophrenia; CESC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg06074448 chr4:187884817 NA -0.38 -5.31 -0.31 2.3e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs116095464 0.558 rs28729548 chr5:229025 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.65 -0.47 5.2e-16 Breast cancer; CESC cis rs6061231 0.631 rs2427317 chr20:60975725 C/T cg22541963 chr20:60982533 CABLES2 0.41 5.27 0.31 2.79e-7 Colorectal cancer; CESC cis rs933688 1.000 rs10041402 chr5:90738948 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 15.79 0.7 4.73e-40 Smoking behavior; CESC cis rs11792861 0.962 rs11789624 chr9:111796231 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.47 5.88 0.34 1.2e-8 Menarche (age at onset); CESC cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs7919006 1.000 rs2395127 chr10:76772778 A/T cg01390419 chr10:76803856 DUPD1 0.4 6.21 0.36 2.08e-9 Weight; CESC cis rs60843830 1.000 rs55753056 chr2:243929 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.89 12.38 0.61 4.3e-28 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs36051895 0.622 rs13440043 chr9:5268264 A/G cg02405213 chr9:5042618 JAK2 -0.54 -6.22 -0.36 1.93e-9 Pediatric autoimmune diseases; CESC cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg06697600 chr4:7070879 GRPEL1 -0.5 -6.32 -0.36 1.13e-9 Monocyte percentage of white cells; CESC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg18225595 chr11:63971243 STIP1 0.74 10.4 0.54 1.79e-21 Platelet count; CESC cis rs933688 0.938 rs7720235 chr5:90659329 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.97 12.87 0.62 9.11e-30 Smoking behavior; CESC trans rs4129059 1.000 rs61443257 chr1:214673211 G/A cg08821431 chr12:34491090 NA 0.56 6.06 0.35 4.7e-9 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26164440 chr3:39195354 CSRNP1 0.54 6.13 0.35 3.17e-9 Gut microbiome composition (summer); CESC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg26343298 chr8:95960752 TP53INP1 0.38 6.36 0.36 8.72e-10 Type 2 diabetes; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02851751 chr10:73574918 CDH23 -0.46 -6.0 -0.35 6.33e-9 Systemic lupus erythematosus; CESC cis rs2839186 0.934 rs2839197 chr21:47708133 A/G cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 7.02e-11 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26401633 chr14:73925225 NUMB 0.45 6.34 0.36 9.62e-10 Fibrinogen levels; CESC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg13206674 chr6:150067644 NUP43 0.43 5.9 0.34 1.1e-8 Lung cancer; CESC cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.76e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4919087 1.000 rs12221430 chr10:99061386 C/G cg25902810 chr10:99078978 FRAT1 0.74 10.75 0.55 1.34e-22 Monocyte count; CESC cis rs910316 1.000 rs876402 chr14:75601862 C/T cg11812906 chr14:75593930 NEK9 -0.91 -15.73 -0.69 7.72e-40 Height; CESC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02624737 chr8:144921531 NRBP2 -0.49 -6.08 -0.35 4.14e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9796 0.866 rs516156 chr15:41381257 A/G cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.23 -0.36 1.78e-9 Menopause (age at onset); CESC cis rs459571 0.959 rs465535 chr9:136910905 C/T cg13789015 chr9:136890014 NCRNA00094 0.52 7.56 0.42 6.52e-13 Platelet distribution width; CESC cis rs6968419 0.788 rs7459377 chr7:115825608 G/A cg02561103 chr7:115862891 TES -0.39 -5.26 -0.31 2.91e-7 Intraocular pressure; CESC cis rs4722166 0.630 rs6969258 chr7:22782528 C/T cg26061582 chr7:22766209 IL6 0.51 5.55 0.32 6.82e-8 Lung cancer; CESC cis rs11098499 0.909 rs28668716 chr4:120309875 T/C cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC trans rs2908835 0.672 rs11613136 chr12:11646428 C/G cg09915232 chr8:1879280 ARHGEF10 -0.65 -6.39 -0.37 7.56e-10 Information processing speed; CESC cis rs3768617 0.510 rs2027083 chr1:183088330 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.49e-35 Fuchs's corneal dystrophy; CESC cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg11752832 chr7:134001865 SLC35B4 0.57 7.52 0.42 8.7e-13 Mean platelet volume; CESC cis rs2070997 0.607 rs3847190 chr9:133715590 C/T cg11464064 chr9:133710261 ABL1 0.67 7.55 0.42 6.92e-13 Response to amphetamines; CESC cis rs3096299 0.728 rs1011749 chr16:89510869 G/C cg00750074 chr16:89608354 SPG7 -0.43 -6.29 -0.36 1.29e-9 Multiple myeloma (IgH translocation); CESC cis rs2204008 0.641 rs66876045 chr12:38205713 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.3 0.53 3.96e-21 Bladder cancer; CESC cis rs76793172 0.623 rs8107744 chr19:46300848 C/A cg11657440 chr19:46296263 DMWD 0.57 5.05 0.3 8.34e-7 Eosinophil counts; CESC cis rs1215050 0.904 rs9307215 chr4:98813965 A/G cg05340658 chr4:99064831 C4orf37 0.52 6.23 0.36 1.85e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs13102973 0.965 rs4597893 chr4:135863043 C/T cg14419869 chr4:135874104 NA -0.39 -6.16 -0.35 2.69e-9 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14824382 chr8:144680115 EEF1D;TIGD5 0.63 6.97 0.39 2.47e-11 Gut microbiome composition (summer); CESC cis rs1153858 1.000 rs9783731 chr15:45642884 C/T cg14582100 chr15:45693742 SPATA5L1 -0.4 -5.79 -0.34 1.97e-8 Homoarginine levels; CESC cis rs7202877 0.706 rs247438 chr16:75432649 C/G cg04384234 chr16:75411784 CFDP1 0.51 6.17 0.35 2.52e-9 Type 2 diabetes;Type 1 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12799349 chr18:9475500 RALBP1 -0.36 -6.01 -0.35 6.2e-9 Gambling; CESC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg26769984 chr7:1090371 C7orf50 0.54 6.33 0.36 1.02e-9 Bronchopulmonary dysplasia; CESC cis rs938554 0.513 rs3775946 chr4:9995256 A/G cg00071950 chr4:10020882 SLC2A9 0.67 8.7 0.47 3.66e-16 Blood metabolite levels; CESC cis rs7927771 0.524 rs10742824 chr11:47864842 C/T cg20307385 chr11:47447363 PSMC3 0.63 8.77 0.47 2.17e-16 Subjective well-being; CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg18402987 chr7:1209562 NA 0.63 7.35 0.41 2.5e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.93 0.39 3.18e-11 Intelligence (multi-trait analysis); CESC cis rs6089584 0.927 rs6089593 chr20:60572312 G/A cg24733560 chr20:60626293 TAF4 0.39 5.58 0.32 5.9e-8 Body mass index; CESC cis rs9614461 0.702 rs2294202 chr22:45738327 A/T cg23503501 chr22:45809793 SMC1B;RIBC2 0.64 6.2 0.36 2.21e-9 Tonsillectomy; CESC cis rs6991838 0.584 rs6993876 chr8:66513475 C/T cg13398993 chr8:66546079 ARMC1 0.45 5.56 0.32 6.5e-8 Intelligence (multi-trait analysis); CESC cis rs863345 0.604 rs11264977 chr1:158447852 G/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.18 -0.4 7.1e-12 Pneumococcal bacteremia; CESC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg23281280 chr6:28129359 ZNF389 0.51 6.93 0.39 3.16e-11 Parkinson's disease; CESC cis rs1371867 0.875 rs1788184 chr8:101335106 A/G cg11906718 chr8:101322791 RNF19A 0.46 5.91 0.34 1.03e-8 Atrioventricular conduction; CESC trans rs629535 0.814 rs62513376 chr8:70086881 C/T cg21567404 chr3:27674614 NA -0.87 -10.34 -0.54 2.9e-21 Dupuytren's disease; CESC cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6963495 0.818 rs73192107 chr7:105168095 G/A cg19920283 chr7:105172520 RINT1 0.69 6.54 0.37 3.15e-10 Bipolar disorder (body mass index interaction); CESC cis rs478222 1.000 rs567359 chr2:25304574 C/T cg01884057 chr2:25150051 NA 0.31 5.42 0.32 1.32e-7 Type 1 diabetes; CESC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg07414643 chr4:187882934 NA 0.36 5.16 0.3 4.87e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.64 -0.38 1.75e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4711336 1.000 rs2296741 chr6:33659557 C/T cg14003231 chr6:33640908 ITPR3 0.32 5.55 0.32 7.05e-8 Height; CESC cis rs2180341 0.924 rs877661 chr6:127587915 T/G cg27446573 chr6:127587934 RNF146 1.07 15.9 0.7 1.99e-40 Breast cancer; CESC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg01238044 chr22:24384105 GSTT1 -0.5 -6.19 -0.36 2.28e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7267979 1.000 rs6050629 chr20:25430680 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 3e-48 Liver enzyme levels (alkaline phosphatase); CESC trans rs11750092 0.525 rs6884129 chr5:159378582 C/G cg20411384 chr7:90670577 CDK14 0.58 6.13 0.35 3.18e-9 Migraine; CESC cis rs1322639 0.571 rs13204417 chr6:169575355 G/A cg04662567 chr6:169592167 NA 0.41 5.85 0.34 1.41e-8 Pulse pressure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14179065 chr9:71682302 FXN 0.48 6.21 0.36 2.08e-9 Gut microbiota (bacterial taxa); CESC cis rs2742234 0.579 rs2503881 chr10:43686026 T/C cg15436174 chr10:43711423 RASGEF1A -0.5 -5.84 -0.34 1.5e-8 Hirschsprung disease; CESC cis rs1559088 0.948 rs6510346 chr19:33598526 T/A cg27124370 chr19:33622961 WDR88 0.46 6.11 0.35 3.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs62432291 0.681 rs2501176 chr6:159655383 A/G cg14500486 chr6:159655392 FNDC1 -0.62 -6.21 -0.36 2.04e-9 Joint mobility (Beighton score); CESC cis rs6545883 0.929 rs12617911 chr2:61740825 A/G cg15711740 chr2:61764176 XPO1 -0.43 -5.23 -0.31 3.39e-7 Tuberculosis; CESC cis rs1620921 0.505 rs9458032 chr6:161210205 G/T cg01280913 chr6:161186852 NA -0.39 -5.56 -0.32 6.49e-8 Lipoprotein (a) - cholesterol levels; CESC cis rs763121 0.962 rs2071887 chr22:38879010 A/T cg06022373 chr22:39101656 GTPBP1 0.66 9.34 0.5 4.03e-18 Menopause (age at onset); CESC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg23708337 chr7:1209742 NA 0.55 5.42 0.32 1.33e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1018836 0.923 rs4735260 chr8:91617157 C/G cg16814680 chr8:91681699 NA 0.7 9.85 0.52 1.05e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs56346965 0.967 rs2159819 chr2:191532737 C/G cg27211696 chr2:191398769 TMEM194B -0.42 -5.53 -0.32 7.69e-8 Bone mineral density (Ward's triangle area); CESC cis rs11190604 1.000 rs2495758 chr10:102321900 C/G cg07080220 chr10:102295463 HIF1AN 0.62 5.57 0.32 6.31e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg25036284 chr2:26402008 FAM59B -0.84 -9.62 -0.51 5.37e-19 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26027796 chr19:55962686 NA -0.49 -6.14 -0.35 3.04e-9 Gut microbiome composition (summer); CESC cis rs5758511 0.514 rs5758629 chr22:42574555 C/T cg00645731 chr22:42541494 CYP2D7P1 0.61 9.33 0.5 4.4e-18 Birth weight; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24999111 chr2:85830196 TMEM150A 0.58 6.2 0.36 2.12e-9 Gut microbiome composition (summer); CESC cis rs6580649 0.941 rs4760615 chr12:48428150 A/G cg24011408 chr12:48396354 COL2A1 0.41 5.16 0.3 4.88e-7 Lung cancer; CESC cis rs763121 0.853 rs5757203 chr22:39044152 G/C cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs9393777 0.623 rs3734544 chr6:26468660 G/A cg12826209 chr6:26865740 GUSBL1 0.69 7.47 0.42 1.14e-12 Intelligence (multi-trait analysis); CESC cis rs6502050 0.835 rs4789678 chr17:80101078 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.59 -0.38 2.39e-10 Life satisfaction; CESC cis rs9486715 0.838 rs9400034 chr6:96954566 C/T cg18709589 chr6:96969512 KIAA0776 0.46 6.48 0.37 4.41e-10 Headache; CESC cis rs1153858 1.000 rs2114501 chr15:45670316 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs6545883 0.965 rs6718887 chr2:61727215 G/A cg15711740 chr2:61764176 XPO1 -0.41 -5.24 -0.31 3.23e-7 Tuberculosis; CESC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg27266027 chr21:40555129 PSMG1 0.46 5.55 0.32 6.87e-8 Cognitive function; CESC cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.34 5.55 0.32 6.92e-8 Monocyte percentage of white cells; CESC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg23978390 chr7:1156363 C7orf50 -0.57 -5.87 -0.34 1.32e-8 Bronchopulmonary dysplasia; CESC cis rs3925075 0.966 rs7195945 chr16:31344309 T/C cg02846316 chr16:31340340 ITGAM 0.42 6.76 0.38 8.91e-11 IgA nephropathy; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg09672890 chr17:70536484 NA -0.42 -6.11 -0.35 3.57e-9 Height; CESC cis rs7264396 0.635 rs6060682 chr20:34506331 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.59 7.17 0.4 7.68e-12 Total cholesterol levels; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg23034840 chr1:205782522 SLC41A1 0.72 8.67 0.47 4.43e-16 Menarche (age at onset); CESC cis rs4450798 0.739 rs3856821 chr3:13742240 G/T cg05589046 chr3:13742034 LOC285375 -0.34 -5.47 -0.32 1.04e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs6089829 0.962 rs2277769 chr20:61666805 C/T cg23505145 chr19:12996616 KLF1 0.52 6.92 0.39 3.36e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.72 -9.75 -0.51 2.17e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.65 0.43 3.65e-13 Prudent dietary pattern; CESC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg17971929 chr21:40555470 PSMG1 1.04 15.59 0.69 2.46e-39 Cognitive function; CESC cis rs17384381 0.834 rs12130380 chr1:85901309 T/C cg16011679 chr1:85725395 C1orf52 0.62 6.58 0.37 2.5e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9487051 0.597 rs351746 chr6:109529321 G/A cg01475377 chr6:109611718 NA -0.39 -5.16 -0.3 4.76e-7 Reticulocyte fraction of red cells; CESC cis rs2985684 1.000 rs2224949 chr14:50096560 A/G cg02151108 chr14:50098012 C14orf104 0.4 5.44 0.32 1.21e-7 Carotid intima media thickness; CESC cis rs4835473 0.864 rs5015762 chr4:144658926 G/A cg25736465 chr4:144833511 NA -0.33 -5.18 -0.3 4.3e-7 Immature fraction of reticulocytes; CESC cis rs11250464 0.804 rs11250463 chr10:1406228 T/C cg26394196 chr10:1453818 ADARB2 -0.39 -5.2 -0.3 3.9e-7 Radiation response; CESC cis rs2439831 1.000 rs690316 chr15:43737880 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.54 0.54 6.3e-22 Lung cancer in ever smokers; CESC cis rs4780401 0.755 rs8191285 chr16:11765408 A/G cg01061890 chr16:11836724 TXNDC11 -0.39 -5.07 -0.3 7.41e-7 Rheumatoid arthritis; CESC cis rs2637266 0.765 rs2395391 chr10:78359932 G/A cg18941641 chr10:78392320 NA 0.41 7.64 0.42 3.93e-13 Pulmonary function; CESC trans rs877282 0.945 rs12782447 chr10:771870 C/T cg22713356 chr15:30763199 NA 1.19 11.91 0.59 1.78e-26 Uric acid levels; CESC cis rs11583043 0.575 rs7528842 chr1:101583663 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.48 -5.31 -0.31 2.27e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs9929218 0.953 rs11075696 chr16:68731365 A/G cg02972257 chr16:68554789 NA 0.58 7.05 0.4 1.58e-11 Colorectal cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09299307 chr5:86709023 CCNH -0.45 -6.58 -0.37 2.54e-10 Gambling; CESC cis rs7639513 0.767 rs13060705 chr3:12710016 C/A cg23032965 chr3:12705835 RAF1 0.76 10.86 0.55 5.83e-23 Itch intensity from mosquito bite; CESC cis rs17362650 0.694 rs10929582 chr2:9585200 C/G cg12832956 chr2:9616023 IAH1 0.53 6.42 0.37 6.17e-10 Alcohol dependence (age at onset); CESC cis rs7116495 0.737 rs661290 chr11:71766014 A/G cg18441811 chr11:71824068 C11orf51 -0.81 -5.07 -0.3 7.54e-7 Severe influenza A (H1N1) infection; CESC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.56 0.42 6.43e-13 Tonsillectomy; CESC cis rs2832077 0.527 rs1048546 chr21:30244877 G/T cg03476357 chr21:30257390 N6AMT1 -0.44 -5.51 -0.32 8.68e-8 Cognitive test performance; CESC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg20151795 chr6:28129481 ZNF389 0.45 5.92 0.34 9.77e-9 Depression; CESC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg24308560 chr3:49941425 MST1R 0.58 8.02 0.44 3.52e-14 Body mass index; CESC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg23803603 chr1:2058230 PRKCZ 0.31 5.29 0.31 2.51e-7 Height; CESC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg18876405 chr7:65276391 NA 0.5 6.61 0.38 2.05e-10 Aortic root size; CESC cis rs614226 0.938 rs787824 chr12:120924638 A/G cg01236616 chr12:121019343 POP5 -1.37 -16.82 -0.72 1.1e-43 Type 1 diabetes nephropathy; CESC cis rs10838687 0.800 rs7124958 chr11:47347260 C/T cg25783544 chr11:47291846 MADD 0.57 6.53 0.37 3.43e-10 Proinsulin levels; CESC cis rs561341 0.609 rs7209493 chr17:30197323 A/G cg13647721 chr17:30228624 UTP6 -0.74 -8.47 -0.46 1.72e-15 Hip circumference adjusted for BMI; CESC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg18337363 chr3:52569053 NT5DC2 0.32 5.5 0.32 8.72e-8 Bipolar disorder; CESC cis rs6733011 0.518 rs12992214 chr2:99466337 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.19 -0.3 4.2e-7 Bipolar disorder; CESC cis rs113835537 0.529 rs17580784 chr11:66214859 T/A cg24851651 chr11:66362959 CCS 0.54 6.47 0.37 4.8e-10 Airway imaging phenotypes; CESC cis rs35160687 0.509 rs35723061 chr2:86549088 G/A cg01119172 chr2:86362222 SNORD94;PTCD3 -0.43 -5.73 -0.33 2.77e-8 Night sleep phenotypes; CESC cis rs2072732 0.861 rs12042403 chr1:2950872 T/C cg15211996 chr1:2936768 ACTRT2 0.34 5.95 0.34 8.31e-9 Plateletcrit; CESC cis rs2204008 0.837 rs73112346 chr12:38357606 C/T cg26384229 chr12:38710491 ALG10B 0.73 10.65 0.55 2.87e-22 Bladder cancer; CESC cis rs9896933 0.887 rs78483419 chr17:80870884 T/C cg15664640 chr17:80829946 TBCD -0.52 -5.43 -0.32 1.28e-7 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14793835 chr3:28283034 CMC1 -0.57 -8.06 -0.44 2.56e-14 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19452060 chr12:57914632 DDIT3 0.61 7.45 0.42 1.3e-12 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs28754619 chr14:56088394 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.98 0.34 7.23e-9 Putamen volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03700121 chr11:60610004 CCDC86 -0.43 -6.09 -0.35 4.02e-9 Fibrinogen levels; CESC cis rs9512730 0.592 rs9581865 chr13:28054578 A/C cg08193333 chr13:27998609 GTF3A 0.44 5.17 0.3 4.53e-7 Schizophrenia; CESC trans rs66573146 0.831 rs56300156 chr4:6990813 G/C cg07817883 chr1:32538562 TMEM39B 1.09 7.0 0.4 2.06e-11 Granulocyte percentage of myeloid white cells; CESC cis rs9291683 0.679 rs2241483 chr4:10099831 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.03 -0.49 3.67e-17 Bone mineral density; CESC cis rs9768139 0.627 rs57920447 chr7:158121243 A/G cg25566285 chr7:158114605 PTPRN2 0.49 7.96 0.44 5.07e-14 Calcium levels; CESC cis rs9435341 0.860 rs12406721 chr1:107563243 G/T cg09367891 chr1:107599246 PRMT6 0.71 8.24 0.45 8.08e-15 Facial morphology (factor 21, depth of nasal alae); CESC trans rs9329221 0.537 rs6601415 chr8:9976805 C/A cg06636001 chr8:8085503 FLJ10661 0.51 6.66 0.38 1.56e-10 Neuroticism; CESC cis rs2228479 0.717 rs2286392 chr16:89809549 A/G cg04013166 chr16:89971882 TCF25 0.72 7.87 0.44 9.3e-14 Skin colour saturation; CESC cis rs3762637 1.000 rs12630576 chr3:122139517 A/C cg24169773 chr3:122142474 KPNA1 -0.52 -6.18 -0.36 2.38e-9 LDL cholesterol levels; CESC cis rs7520050 0.933 rs6694340 chr1:46289416 C/T cg03146154 chr1:46216737 IPP -0.48 -6.36 -0.36 8.91e-10 Red blood cell count;Reticulocyte count; CESC cis rs662064 0.852 rs2483677 chr1:10580891 C/T cg20482658 chr1:10539492 PEX14 0.37 7.72 0.43 2.38e-13 Asthma; CESC cis rs6674970 0.627 rs2864700 chr1:151028929 C/T cg11822372 chr1:151115635 SEMA6C 0.42 5.98 0.35 7.05e-9 Childhood ear infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02388999 chr6:131384671 EPB41L2 0.6 7.18 0.4 7.12e-12 Gut microbiome composition (summer); CESC cis rs1847202 0.859 rs4501056 chr3:72948908 A/T cg25664220 chr3:72788482 NA -0.35 -5.3 -0.31 2.48e-7 Motion sickness; CESC cis rs4835473 0.742 rs1838519 chr4:144893395 T/C cg25736465 chr4:144833511 NA 0.4 6.08 0.35 4.15e-9 Immature fraction of reticulocytes; CESC cis rs3820928 1.000 rs61067328 chr2:227761256 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -5.84 -0.34 1.54e-8 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26821823 chr11:75875926 NA -0.5 -6.23 -0.36 1.83e-9 Gut microbiome composition (summer); CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg25934064 chr3:52569026 NT5DC2 0.25 5.32 0.31 2.24e-7 Bipolar disorder; CESC cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.57 -6.75 -0.38 9.04e-11 Multiple sclerosis; CESC cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg20476274 chr7:133979776 SLC35B4 0.68 10.15 0.53 1.19e-20 Mean platelet volume; CESC cis rs2635047 0.935 rs2461247 chr18:44698537 T/G cg19077165 chr18:44547161 KATNAL2 -0.45 -6.06 -0.35 4.56e-9 Educational attainment; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09430689 chr14:76127296 C14orf1;TTLL5 -0.42 -6.27 -0.36 1.46e-9 Gambling; CESC cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7017914 0.934 rs6992879 chr8:71699283 A/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.3 -0.31 2.38e-7 Bone mineral density; CESC cis rs910316 1.000 rs4903281 chr14:75554361 G/C cg11812906 chr14:75593930 NEK9 0.9 15.29 0.68 2.87e-38 Height; CESC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.03 0.35 5.51e-9 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17597744 chr8:53627099 RB1CC1 -0.51 -6.85 -0.39 5.08e-11 Fibrinogen levels; CESC cis rs941764 1.000 rs941764 chr14:91841069 C/T cg10511902 chr14:91842949 CCDC88C -0.45 -6.74 -0.38 1.01e-10 Breast cancer; CESC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg19729930 chr2:74357872 NA 0.68 8.71 0.47 3.39e-16 Gestational age at birth (maternal effect); CESC cis rs4843747 0.671 rs74729706 chr16:88104159 C/T cg17633681 chr16:88106987 BANP 0.76 10.41 0.54 1.68e-21 Menopause (age at onset); CESC cis rs35740288 0.580 rs34635893 chr15:86340248 C/T cg20737812 chr15:86336631 KLHL25 -0.42 -5.34 -0.31 2e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs11785400 0.793 rs9774627 chr8:143731267 G/A cg10596483 chr8:143751796 JRK 0.42 5.31 0.31 2.33e-7 Schizophrenia; CESC cis rs6088580 0.608 rs8114616 chr20:32969092 G/T cg08999081 chr20:33150536 PIGU -0.63 -10.85 -0.55 6.37e-23 Glomerular filtration rate (creatinine); CESC cis rs12618769 0.597 rs2278213 chr2:99136059 A/G cg10123293 chr2:99228465 UNC50 0.39 5.17 0.3 4.62e-7 Bipolar disorder; CESC cis rs4727027 0.933 rs12154382 chr7:148862284 C/T cg23583168 chr7:148888333 NA -0.81 -12.68 -0.61 4.05e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs863345 0.534 rs10797009 chr1:158446048 T/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.69 -0.38 1.29e-10 Pneumococcal bacteremia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01586524 chr8:67341819 RRS1 0.49 6.25 0.36 1.65e-9 Gut microbiota (bacterial taxa); CESC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg11663144 chr21:46675770 NA -0.5 -6.86 -0.39 4.87e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9399135 1.000 rs35123050 chr6:135302740 G/A cg22676075 chr6:135203613 NA 0.5 6.96 0.39 2.62e-11 Red blood cell count; CESC cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg22467129 chr15:76604101 ETFA -0.38 -5.67 -0.33 3.67e-8 Blood metabolite levels; CESC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg26939375 chr7:64535504 NA 0.8 11.57 0.58 2.47e-25 Calcium levels; CESC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg04414720 chr1:150670196 GOLPH3L -0.6 -8.51 -0.46 1.27e-15 Tonsillectomy; CESC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg19346786 chr7:2764209 NA -0.51 -7.13 -0.4 9.3e-12 Height; CESC cis rs11112613 0.713 rs73184081 chr12:105951745 C/T cg03607813 chr12:105948248 NA 0.61 7.56 0.42 6.56e-13 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs9549260 0.755 rs7324319 chr13:41233505 G/C cg21288729 chr13:41239152 FOXO1 0.66 8.61 0.47 6.55e-16 Red blood cell count; CESC cis rs9486719 1.000 rs3906199 chr6:97049899 C/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.78 -0.33 2.12e-8 Migraine;Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27138088 chr11:842605 TSPAN4;POLR2L -0.47 -6.21 -0.36 2e-9 Fibrinogen levels; CESC cis rs9815354 1.000 rs9873207 chr3:41884750 C/T cg03022575 chr3:42003672 ULK4 0.58 6.01 0.35 5.96e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs791888 0.929 rs791887 chr10:89411554 A/G cg13926569 chr10:89418898 PAPSS2 -0.45 -6.5 -0.37 4.05e-10 Magnesium levels; CESC trans rs10007810 0.760 rs7674041 chr4:41590808 A/G cg05088549 chr3:183978344 ECE2;CAMK2N2 -0.48 -6.0 -0.35 6.44e-9 Longevity (90 years and older); CESC cis rs9549367 0.789 rs2316442 chr13:113877487 C/T cg18105134 chr13:113819100 PROZ -0.67 -8.26 -0.45 7.17e-15 Platelet distribution width; CESC cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.19 0.3 4.18e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg05283184 chr6:79620031 NA -0.42 -6.44 -0.37 5.55e-10 Intelligence (multi-trait analysis); CESC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg19052272 chr2:3704530 ALLC -0.79 -8.83 -0.48 1.5e-16 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs7666738 0.830 rs28818218 chr4:98880575 A/C cg05340658 chr4:99064831 C4orf37 0.78 11.74 0.58 6.77e-26 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs34212748 chr4:99068708 G/A cg05340658 chr4:99064831 C4orf37 0.83 12.82 0.62 1.36e-29 Colonoscopy-negative controls vs population controls; CESC cis rs11792861 0.591 rs7027874 chr9:111717112 A/G cg05043794 chr9:111880884 C9orf5 -0.31 -5.64 -0.33 4.4e-8 Menarche (age at onset); CESC cis rs17253792 0.822 rs75288952 chr14:56034010 C/T cg01858014 chr14:56050164 KTN1 -0.94 -6.82 -0.39 6.11e-11 Putamen volume; CESC cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.3 0.31 2.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg16132339 chr22:24313637 DDTL;DDT 0.4 6.05 0.35 4.95e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3820068 0.581 rs72645895 chr1:15931709 G/A cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg20203395 chr5:56204925 C5orf35 -0.43 -5.06 -0.3 7.66e-7 Initial pursuit acceleration; CESC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.55 -0.32 7.08e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7917772 0.503 rs61871067 chr10:104295382 C/T cg22532475 chr10:104410764 TRIM8 -0.44 -6.87 -0.39 4.45e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg18016565 chr1:150552671 MCL1 0.33 5.13 0.3 5.67e-7 Tonsillectomy; CESC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg16325326 chr1:53192061 ZYG11B 0.72 10.54 0.54 6.57e-22 Monocyte count; CESC trans rs5756813 0.727 rs4820303 chr22:38134166 G/A cg19894588 chr14:64061835 NA -0.66 -7.81 -0.43 1.35e-13 Optic cup area;Vertical cup-disc ratio; CESC cis rs9549260 0.564 rs12184871 chr13:41291928 C/A cg21288729 chr13:41239152 FOXO1 0.56 7.25 0.41 4.67e-12 Red blood cell count; CESC cis rs9788682 0.747 rs7183604 chr15:78899213 T/C cg24631222 chr15:78858424 CHRNA5 -0.81 -10.17 -0.53 1.03e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7714584 1.000 rs17111376 chr5:150226899 T/C cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs116095464 0.614 rs10061564 chr5:271329 T/C cg22857025 chr5:266934 NA -1.3 -18.75 -0.76 1.71e-50 Breast cancer; CESC cis rs453301 0.571 rs2929454 chr8:9083854 A/C cg06636001 chr8:8085503 FLJ10661 -0.53 -6.82 -0.39 6.09e-11 Joint mobility (Beighton score); CESC cis rs7605827 0.930 rs1469016 chr2:15687627 A/G cg19274914 chr2:15703543 NA 0.37 6.67 0.38 1.5e-10 Educational attainment (years of education); CESC cis rs9768139 0.935 rs7782393 chr7:158120486 G/A cg24154853 chr7:158122151 PTPRN2 -0.38 -5.95 -0.34 8.46e-9 Calcium levels; CESC cis rs9291683 0.546 rs13129453 chr4:10044784 T/C cg02734326 chr4:10020555 SLC2A9 0.45 6.19 0.36 2.29e-9 Bone mineral density; CESC cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg15017067 chr4:17643749 FAM184B 0.4 5.75 0.33 2.46e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4481887 0.962 rs6587452 chr1:248485931 C/T cg00666640 chr1:248458726 OR2T12 0.41 6.74 0.38 9.64e-11 Common traits (Other); CESC cis rs250677 0.687 rs3095947 chr5:148436728 T/C cg18129178 chr5:148520854 ABLIM3 -0.48 -5.48 -0.32 1e-7 Breast cancer; CESC cis rs9487051 0.735 rs1341272 chr6:109507533 C/T cg01475377 chr6:109611718 NA 0.37 5.48 0.32 9.72e-8 Reticulocyte fraction of red cells; CESC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg09365446 chr1:150670422 GOLPH3L 0.41 5.76 0.33 2.36e-8 Tonsillectomy; CESC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg19257562 chr1:2043853 PRKCZ -0.32 -5.05 -0.3 8.39e-7 Height; CESC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC cis rs2180341 1.000 rs6569482 chr6:127631371 C/T cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6e-39 Breast cancer; CESC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg15664640 chr17:80829946 TBCD 0.41 5.83 0.34 1.61e-8 Breast cancer; CESC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg24675658 chr1:53192096 ZYG11B -0.59 -7.38 -0.41 2.07e-12 Monocyte count; CESC cis rs11587400 0.634 rs4839385 chr1:115121461 A/G cg12756093 chr1:115239321 AMPD1 0.42 5.69 0.33 3.33e-8 Autism; CESC cis rs4604732 0.685 rs4925673 chr1:247636800 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.46 6.57 0.37 2.73e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs28489187 0.577 rs6697083 chr1:85887775 A/T cg16011679 chr1:85725395 C1orf52 -0.43 -5.13 -0.3 5.74e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg25036284 chr2:26402008 FAM59B -0.75 -8.44 -0.46 2.15e-15 Gut microbiome composition (summer); CESC cis rs539096 0.500 rs2527776 chr1:44345292 G/A cg12908607 chr1:44402522 ARTN -0.49 -7.4 -0.41 1.82e-12 Intelligence (multi-trait analysis); CESC cis rs2777491 0.957 rs919961 chr15:41651721 A/G cg20272979 chr15:41787780 ITPKA 0.35 5.1 0.3 6.42e-7 Ulcerative colitis; CESC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg00166722 chr3:10149974 C3orf24 0.46 5.88 0.34 1.21e-8 Alzheimer's disease; CESC cis rs4906332 1.000 rs7155822 chr14:103922390 A/G cg09975044 chr14:104007538 NA 0.45 6.17 0.35 2.59e-9 Coronary artery disease; CESC cis rs113835537 0.529 rs11824771 chr11:66262550 T/C cg22134325 chr11:66188745 NPAS4 0.35 5.58 0.32 5.8e-8 Airway imaging phenotypes; CESC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg00684032 chr4:1343700 KIAA1530 0.41 5.78 0.33 2.04e-8 Obesity-related traits; CESC cis rs11997175 0.646 rs4609158 chr8:33693420 A/G ch.8.33884649F chr8:33765107 NA 0.56 7.36 0.41 2.29e-12 Body mass index; CESC cis rs1465370 0.800 rs62471721 chr7:130016470 G/A cg04743876 chr7:130013617 NA 0.27 5.05 0.3 8.28e-7 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs10861342 1.000 rs10861337 chr12:105452442 G/A cg23923672 chr12:105501055 KIAA1033 0.72 5.32 0.31 2.21e-7 IgG glycosylation; CESC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs7584330 0.737 rs1497128 chr2:238369211 A/G cg14458575 chr2:238380390 NA 0.53 7.47 0.42 1.14e-12 Prostate cancer; CESC cis rs7429990 0.965 rs6772396 chr3:47959770 A/G cg11946769 chr3:48343235 NME6 0.42 5.17 0.3 4.73e-7 Educational attainment (years of education); CESC cis rs1499614 1.000 rs2707838 chr7:66159201 C/T cg13147721 chr7:65941812 NA -0.94 -8.9 -0.48 9.08e-17 Gout; CESC cis rs3733585 0.605 rs4235354 chr4:10122942 C/A cg02734326 chr4:10020555 SLC2A9 -0.37 -5.03 -0.3 8.89e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg12193833 chr17:30244370 NA -0.71 -6.35 -0.36 9.53e-10 Hip circumference adjusted for BMI; CESC cis rs4835473 0.798 rs11100829 chr4:144905914 G/C cg25736465 chr4:144833511 NA 0.41 6.11 0.35 3.5e-9 Immature fraction of reticulocytes; CESC cis rs7827545 1.000 rs7827545 chr8:135566567 C/T cg17885191 chr8:135476712 NA 0.48 6.31 0.36 1.17e-9 Hypertension (SNP x SNP interaction); CESC cis rs6496667 0.509 rs2253419 chr15:90945875 A/G cg10434728 chr15:90938212 IQGAP1 0.33 5.81 0.34 1.75e-8 Rheumatoid arthritis; CESC cis rs10883723 0.810 rs3781289 chr10:104244991 G/T ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.21 0.3 3.78e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs910316 0.789 rs12894419 chr14:75471802 C/T cg11812906 chr14:75593930 NEK9 0.77 12.19 0.6 2.01e-27 Height; CESC cis rs6087771 0.714 rs6058259 chr20:30235302 A/G cg13852791 chr20:30311386 BCL2L1 0.77 9.66 0.51 4.05e-19 Subcortical brain region volumes;Putamen volume; CESC cis rs2191566 0.691 rs8104437 chr19:44588789 C/T cg20607764 chr19:44506953 ZNF230 -0.4 -5.31 -0.31 2.3e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg19346786 chr7:2764209 NA -0.51 -7.54 -0.42 7.64e-13 Height; CESC cis rs367615 0.680 rs31595 chr5:108979318 T/C cg17395555 chr5:108820864 NA 0.41 5.82 0.34 1.69e-8 Colorectal cancer (SNP x SNP interaction); CESC cis rs2120019 0.938 rs13056 chr15:75312187 A/G cg17294928 chr15:75287854 SCAMP5 -0.73 -8.69 -0.47 3.87e-16 Blood trace element (Zn levels); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15854934 chr14:55518152 MAPK1IP1L -0.44 -6.19 -0.36 2.3e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9815354 1.000 rs9840037 chr3:41827522 C/T cg03022575 chr3:42003672 ULK4 0.47 5.15 0.3 4.98e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7666738 0.830 rs11725652 chr4:98878362 G/A cg03467027 chr4:99064603 C4orf37 0.42 5.15 0.3 5.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7017697 0.642 rs3927029 chr8:19681933 G/A cg03894339 chr8:19674705 INTS10 -0.54 -5.77 -0.33 2.15e-8 Breast cancer; CESC cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg06115741 chr20:33292138 TP53INP2 0.56 6.92 0.39 3.49e-11 Coronary artery disease; CESC trans rs6570726 0.791 rs379040 chr6:145889035 T/C cg03826317 chr10:25465503 LOC100128811;GPR158 0.31 6.03 0.35 5.38e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs5753618 0.583 rs5749268 chr22:31809152 G/A cg00478049 chr22:31556069 RNF185 -0.43 -5.11 -0.3 6.22e-7 Colorectal cancer; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg03700279 chr2:44576358 PREPL 0.42 6.8 0.39 6.85e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9296736 0.885 rs9349693 chr6:53939724 A/G cg04374786 chr6:53939321 C6orf142 0.35 5.5 0.32 9.06e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg10556349 chr10:835070 NA 0.76 6.35 0.36 9.42e-10 Eosinophil percentage of granulocytes; CESC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg09699651 chr6:150184138 LRP11 0.4 5.08 0.3 7.23e-7 Lung cancer; CESC cis rs11690935 0.610 rs3770458 chr2:172651287 C/T cg13550731 chr2:172543902 DYNC1I2 0.55 7.6 0.42 4.99e-13 Schizophrenia; CESC cis rs6499255 0.951 rs57488237 chr16:69741571 T/C cg15192750 chr16:69999425 NA 0.5 6.01 0.35 5.97e-9 IgE levels; CESC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.28 0.63 3.39e-31 Prudent dietary pattern; CESC cis rs2777491 1.000 rs66538814 chr15:41685917 G/T cg18705301 chr15:41695430 NDUFAF1 -0.63 -9.59 -0.51 6.63e-19 Ulcerative colitis; CESC cis rs2742234 0.590 rs2435377 chr10:43683600 A/G cg15436174 chr10:43711423 RASGEF1A 0.48 5.6 0.33 5.46e-8 Hirschsprung disease; CESC trans rs116095464 0.558 rs7708182 chr5:234788 C/G cg00938859 chr5:1591904 SDHAP3 0.63 6.98 0.39 2.36e-11 Breast cancer; CESC cis rs7100689 0.753 rs1361458 chr10:82090339 A/T cg09936400 chr10:82049201 MAT1A 0.37 5.28 0.31 2.75e-7 Post bronchodilator FEV1; CESC cis rs2797685 1.000 rs2859390 chr1:7847529 A/G cg04725166 chr1:7887271 PER3 -0.46 -6.36 -0.36 8.98e-10 Crohn's disease; CESC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.4 0.41 1.75e-12 Tonsillectomy; CESC cis rs2739330 0.892 rs5751776 chr22:24266954 A/C cg11905131 chr22:24372483 LOC391322 -0.83 -12.91 -0.62 6.48e-30 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2439831 0.867 rs2899082 chr15:43656043 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.93 11.25 0.57 2.98e-24 Lung cancer in ever smokers; CESC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.71 0.38 1.16e-10 Electroencephalogram traits; CESC cis rs4243830 0.737 rs11122083 chr1:6593532 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -6.51 -0.37 3.7e-10 Body mass index; CESC cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg23711669 chr6:146136114 FBXO30 -0.88 -13.21 -0.63 5.93e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg22920501 chr2:26401640 FAM59B -0.91 -10.33 -0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs478304 0.651 rs4014195 chr11:65506822 C/G cg10518572 chr11:65560635 OVOL1 0.34 7.12 0.4 1.04e-11 Acne (severe); CESC cis rs7927771 0.524 rs7943464 chr11:47886639 T/A cg20307385 chr11:47447363 PSMC3 0.63 8.84 0.48 1.39e-16 Subjective well-being; CESC cis rs36051895 0.695 rs10974921 chr9:5024427 T/A cg02405213 chr9:5042618 JAK2 -0.5 -5.63 -0.33 4.66e-8 Pediatric autoimmune diseases; CESC cis rs68170813 0.559 rs2023892 chr7:106847686 C/T cg02696742 chr7:106810147 HBP1 0.5 5.03 0.3 9.04e-7 Coronary artery disease; CESC cis rs3540 0.533 rs2352601 chr15:91053125 G/A cg22089800 chr15:90895588 ZNF774 -0.63 -8.41 -0.46 2.49e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs12220238 1.000 rs11000916 chr10:75953909 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.44 0.32 1.24e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs1707322 0.721 rs28442079 chr1:46172001 A/G cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg06873352 chr17:61820015 STRADA 0.68 11.14 0.56 6.69e-24 Prudent dietary pattern; CESC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg11764359 chr7:65958608 NA -0.46 -5.72 -0.33 2.88e-8 Calcium levels; CESC trans rs10506458 0.915 rs1009540 chr12:63414872 C/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -18.64 -0.75 4.04e-50 Hemostatic factors and hematological phenotypes; CESC cis rs116095464 0.681 rs9687745 chr5:229309 C/T cg22857025 chr5:266934 NA -1.27 -18.52 -0.75 1.07e-49 Breast cancer; CESC cis rs2439831 0.850 rs8023458 chr15:44080939 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.87 0.39 4.52e-11 Lung cancer in ever smokers; CESC cis rs9303401 0.659 rs12150264 chr17:56939927 G/A cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.69 0.61 3.78e-29 Cognitive test performance; CESC cis rs11785400 0.793 rs9774627 chr8:143731267 G/A cg24634471 chr8:143751801 JRK 0.45 5.75 0.33 2.43e-8 Schizophrenia; CESC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07926482 chr16:84651521 COTL1 0.71 7.72 0.43 2.38e-13 Gut microbiome composition (summer); CESC cis rs6570726 0.818 rs399516 chr6:145810849 C/A cg05347473 chr6:146136440 FBXO30 0.52 6.93 0.39 3.29e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg10523679 chr1:76189770 ACADM 0.66 7.45 0.42 1.34e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1728785 0.901 rs1645934 chr16:68564490 T/A cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs9894429 0.816 rs9747093 chr17:79584280 G/A cg18240062 chr17:79603768 NPLOC4 0.71 10.24 0.53 5.93e-21 Eye color traits; CESC cis rs9916302 0.904 rs12452880 chr17:37591149 G/C cg20243544 chr17:37824526 PNMT 0.5 6.37 0.36 8.48e-10 Glomerular filtration rate (creatinine); CESC cis rs3761218 0.738 rs6084472 chr20:3771858 G/T cg25011176 chr20:3776985 CDC25B -0.46 -6.03 -0.35 5.63e-9 Bipolar disorder; CESC cis rs2130392 0.962 rs35613786 chr4:185625657 A/G cg21366198 chr4:185655624 MLF1IP 0.43 6.06 0.35 4.64e-9 Kawasaki disease; CESC cis rs12477438 0.765 rs56167745 chr2:99600478 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -9.2 -0.49 1.14e-17 Chronic sinus infection; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08958952 chr8:142262761 NA 0.44 6.03 0.35 5.57e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs367943 0.712 rs1120091 chr5:112684229 C/A cg12552261 chr5:112820674 MCC 0.41 5.3 0.31 2.49e-7 Type 2 diabetes; CESC cis rs12681288 0.862 rs2701898 chr8:1020812 C/T cg04851639 chr8:1020857 NA -0.38 -8.16 -0.45 1.39e-14 Schizophrenia; CESC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg21782813 chr7:2030301 MAD1L1 0.41 5.83 0.34 1.61e-8 Bipolar disorder and schizophrenia; CESC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg22800045 chr5:56110881 MAP3K1 0.7 8.3 0.45 5.23e-15 Initial pursuit acceleration; CESC cis rs3820068 0.554 rs60233444 chr1:15921330 A/C cg16988262 chr1:15930761 NA 0.35 5.63 0.33 4.6e-8 Systolic blood pressure; CESC cis rs34375054 0.558 rs67041765 chr12:125672913 T/G cg25124228 chr12:125621409 AACS -0.52 -6.11 -0.35 3.52e-9 Post bronchodilator FEV1/FVC ratio; CESC trans rs317865 0.520 rs75252501 chr4:16337280 C/T cg26256793 chr1:103574469 COL11A1 -0.66 -6.25 -0.36 1.65e-9 Kidney disease (early stage) in type 1 diabetes; CESC cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg24308560 chr3:49941425 MST1R 0.54 7.56 0.42 6.56e-13 Body mass index; CESC cis rs477692 0.699 rs509017 chr10:131367174 T/G cg05714579 chr10:131428358 MGMT 0.4 5.17 0.3 4.61e-7 Response to temozolomide; CESC cis rs9303280 0.776 rs11078926 chr17:38062976 G/A cg19468946 chr17:37922297 IKZF3 -0.39 -5.2 -0.3 4.07e-7 Self-reported allergy; CESC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg11644478 chr21:40555479 PSMG1 -0.51 -6.96 -0.39 2.64e-11 Menarche (age at onset); CESC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg00750074 chr16:89608354 SPG7 0.41 6.09 0.35 3.9e-9 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00214165 chr5:7869652 MTRR;FASTKD3 0.6 6.55 0.37 2.92e-10 Gut microbiome composition (summer); CESC cis rs3845702 0.736 rs56401468 chr2:180857757 C/T cg01881094 chr2:180872142 CWC22 1.11 9.6 0.51 6.33e-19 Schizophrenia; CESC cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg03060546 chr3:49711283 APEH 0.64 7.27 0.41 4.1e-12 Menarche (age at onset); CESC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.61e-7 Life satisfaction; CESC cis rs2708240 0.666 rs2708270 chr7:147594647 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.37 -6.16 -0.35 2.71e-9 QT interval (drug interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12568776 chr9:112083456 EPB41L4B -0.55 -6.2 -0.36 2.15e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.85 12.31 0.6 7.61e-28 Prudent dietary pattern; CESC cis rs8067545 0.750 rs3862152 chr17:19959693 C/T cg13482628 chr17:19912719 NA 0.4 5.41 0.32 1.39e-7 Schizophrenia; CESC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg18240062 chr17:79603768 NPLOC4 0.51 6.76 0.38 8.81e-11 Eye color traits; CESC trans rs11989744 1.000 rs34389484 chr8:23572963 T/G cg03492747 chr16:86543808 FOXF1 0.69 7.71 0.43 2.59e-13 Waist-hip ratio; CESC cis rs2243480 1.000 rs4718333 chr7:65772758 T/C cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs763121 0.815 rs4821799 chr22:39021326 T/G cg06544989 chr22:39130855 UNC84B 0.47 8.5 0.46 1.41e-15 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23104823 chr14:45553408 PRPF39 0.53 7.31 0.41 3.18e-12 Gut microbiota (bacterial taxa); CESC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg08470875 chr2:26401718 FAM59B -0.47 -5.24 -0.31 3.31e-7 Gut microbiome composition (summer); CESC cis rs61332075 0.501 rs56387323 chr2:239387399 T/C cg18131467 chr2:239335373 ASB1 -0.73 -5.88 -0.34 1.23e-8 Lung function (FEV1/FVC); CESC cis rs1048238 0.506 rs56352596 chr1:16297592 G/A cg22431228 chr1:16359049 CLCNKA -0.36 -6.42 -0.37 6.43e-10 Systolic blood pressure; CESC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg05332525 chr7:65337924 VKORC1L1 0.52 6.43 0.37 6.04e-10 Calcium levels; CESC cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg02935154 chr7:12443704 VWDE -0.58 -6.25 -0.36 1.67e-9 Coronary artery disease; CESC cis rs6502050 0.835 rs8073351 chr17:80127625 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.61e-10 Life satisfaction; CESC cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg04287289 chr16:89883240 FANCA -0.62 -8.33 -0.46 4.39e-15 Vitiligo; CESC cis rs453301 0.592 rs4841084 chr8:8883905 C/T cg15556689 chr8:8085844 FLJ10661 0.49 6.32 0.36 1.11e-9 Joint mobility (Beighton score); CESC cis rs12586317 0.620 rs58320987 chr14:35587726 T/C cg16230307 chr14:35515116 FAM177A1 0.93 10.09 0.53 1.81e-20 Psoriasis; CESC cis rs11204677 1 rs11204677 chr1:150574695 C/G cg17724175 chr1:150552817 MCL1 -0.33 -5.24 -0.31 3.23e-7 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs2797160 1.000 rs1418639 chr6:125999940 C/T cg05901451 chr6:126070800 HEY2 -0.45 -6.67 -0.38 1.44e-10 Endometrial cancer; CESC cis rs4409675 0.576 rs10794507 chr1:28216072 T/C cg23691781 chr1:28212827 C1orf38 0.28 5.77 0.33 2.2e-8 Corneal astigmatism; CESC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19473056 chr3:41996898 ULK4 0.47 6.17 0.35 2.6e-9 Fibrinogen levels; CESC cis rs11203032 0.831 rs4511206 chr10:90968759 C/T cg16672925 chr10:90967113 CH25H 0.73 7.09 0.4 1.23e-11 Heart failure; CESC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.87e-17 Tonsillectomy; CESC cis rs11997175 0.625 rs4733171 chr8:33615617 C/G ch.8.33884649F chr8:33765107 NA -0.5 -6.19 -0.36 2.26e-9 Body mass index; CESC trans rs7726839 0.540 rs72703095 chr5:601789 T/C cg25482853 chr8:67687455 SGK3 1.04 10.09 0.53 1.78e-20 Obesity-related traits; CESC cis rs9649465 1.000 rs6950659 chr7:123361910 C/T cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.33e-7 Migraine; CESC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg11987759 chr7:65425863 GUSB 0.48 6.51 0.37 3.76e-10 Calcium levels; CESC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg25036284 chr2:26402008 FAM59B 0.86 9.36 0.5 3.44e-18 Gut microbiome composition (summer); CESC cis rs12477438 0.798 rs6705583 chr2:99602625 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -11.02 -0.56 1.73e-23 Chronic sinus infection; CESC cis rs1707322 0.752 rs8179296 chr1:46143791 G/A cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2727020 0.521 rs7126835 chr11:49594658 T/C cg03929089 chr4:120376271 NA -0.73 -8.36 -0.46 3.57e-15 Coronary artery disease; CESC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -5.07 -0.3 7.32e-7 Bipolar disorder; CESC cis rs4660306 0.961 rs4660871 chr1:45995232 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.51 -6.59 -0.38 2.31e-10 Homocysteine levels; CESC trans rs66573146 0.803 rs59742225 chr4:6969942 C/T cg07817883 chr1:32538562 TMEM39B 1.49 9.04 0.49 3.38e-17 Granulocyte percentage of myeloid white cells; CESC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg24550644 chr17:30846204 MYO1D -0.37 -5.32 -0.31 2.26e-7 Schizophrenia; CESC cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4975616 0.869 rs401681 chr5:1322087 C/T cg07493874 chr5:1342172 CLPTM1L -0.39 -7.52 -0.42 8.27e-13 Lung cancer; CESC cis rs2073300 0.609 rs6137913 chr20:23357725 C/T cg16736954 chr20:23401023 NAPB 0.6 5.16 0.3 4.96e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12163800 chr17:74475355 RHBDF2 0.44 6.74 0.38 1.01e-10 Fibrinogen levels; CESC cis rs4566357 0.615 rs12328878 chr2:227918962 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.02 -0.4 1.84e-11 Coronary artery disease; CESC cis rs11098499 1.000 rs1011054 chr4:120202387 A/G cg09307838 chr4:120376055 NA -0.87 -11.6 -0.58 1.92e-25 Corneal astigmatism; CESC cis rs9929218 1.000 rs9937664 chr16:68784603 T/C cg02972257 chr16:68554789 NA 0.53 6.0 0.35 6.54e-9 Colorectal cancer; CESC cis rs4423214 0.879 rs1792284 chr11:71134966 A/G cg05163923 chr11:71159392 DHCR7 0.66 7.61 0.42 4.68e-13 Vitamin D levels; CESC cis rs910316 1.000 rs10873275 chr14:75531460 A/T cg11812906 chr14:75593930 NEK9 0.89 14.87 0.67 8.9e-37 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10808102 chr17:25783956 NA -0.43 -6.02 -0.35 5.87e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs853679 0.556 rs34588114 chr6:28080628 C/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 5.58 0.32 6.04e-8 Depression; CESC cis rs16854884 0.586 rs6440212 chr3:143748526 T/C cg06585982 chr3:143692056 C3orf58 0.51 6.92 0.39 3.46e-11 Economic and political preferences (feminism/equality); CESC cis rs6991838 0.584 rs10092109 chr8:66539918 C/T cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs854765 0.616 rs8076747 chr17:17853595 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.65 9.41 0.5 2.47e-18 Total body bone mineral density; CESC cis rs6032067 0.925 rs35751129 chr20:43847658 C/A cg10761708 chr20:43804764 PI3 0.51 6.04 0.35 5.34e-9 Blood protein levels; CESC cis rs9303401 0.592 rs66583824 chr17:56639853 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.56e-29 Cognitive test performance; CESC cis rs17431357 1.000 rs73225225 chr12:120960474 G/A cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs7296418 0.883 rs1727312 chr12:123642220 G/T cg00376283 chr12:123451042 ABCB9 0.68 9.61 0.51 5.81e-19 Platelet count; CESC trans rs1814175 0.645 rs12364337 chr11:49942580 A/T cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs72627123 0.582 rs62005101 chr14:74500585 A/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.56 5.57 0.32 6.34e-8 Morning vs. evening chronotype; CESC cis rs8141529 0.509 rs5762853 chr22:29245231 T/G cg15103426 chr22:29168792 CCDC117 0.61 7.96 0.44 5.03e-14 Lymphocyte counts; CESC cis rs4594175 0.962 rs7157823 chr14:51633170 C/T cg23942311 chr14:51606299 NA 0.4 6.11 0.35 3.51e-9 Cancer; CESC cis rs4472734 1.000 rs4655346 chr1:214609127 T/G cg00063699 chr1:214624242 PTPN14 -0.34 -5.41 -0.32 1.4e-7 Height; CESC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg11644478 chr21:40555479 PSMG1 0.99 14.27 0.66 1.18e-34 Cognitive function; CESC cis rs3096299 0.582 rs12935119 chr16:89542874 A/T cg02187348 chr16:89574699 SPG7 0.53 7.14 0.4 9.2e-12 Multiple myeloma (IgH translocation); CESC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg13777783 chr17:79615861 NA -0.36 -6.12 -0.35 3.32e-9 Eye color traits; CESC cis rs11098499 0.754 rs12506610 chr4:120241659 T/C cg09307838 chr4:120376055 NA 0.79 10.62 0.55 3.51e-22 Corneal astigmatism; CESC cis rs4819052 0.959 rs9976074 chr21:46655638 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.82 9.91 0.52 6.87e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6964587 1.000 rs10243241 chr7:91705696 A/G cg17063962 chr7:91808500 NA 0.59 8.09 0.45 2.1e-14 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19227446 chr19:48247023 NA -0.46 -6.04 -0.35 5.26e-9 Fibrinogen levels; CESC cis rs6493487 0.512 rs17599863 chr15:51219962 G/A cg02338191 chr15:51200825 AP4E1 0.6 5.43 0.32 1.26e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs11098499 0.863 rs1010740 chr4:120463409 C/T cg24375607 chr4:120327624 NA -0.45 -5.41 -0.32 1.39e-7 Corneal astigmatism; CESC cis rs12530845 0.623 rs73721664 chr7:135343575 A/C cg23117316 chr7:135346802 PL-5283 -0.59 -6.54 -0.37 3.15e-10 Red blood cell traits; CESC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.45 5.48 0.32 9.97e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7845219 0.544 rs9643351 chr8:95917290 C/T cg09323728 chr8:95962352 TP53INP1 -0.33 -6.35 -0.36 9.17e-10 Type 2 diabetes; CESC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg18301423 chr5:131593218 PDLIM4 -0.39 -5.28 -0.31 2.67e-7 Acylcarnitine levels; CESC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs116095464 0.558 rs55833259 chr5:286728 G/A cg22857025 chr5:266934 NA -1.32 -14.16 -0.66 2.9e-34 Breast cancer; CESC cis rs9399137 0.507 rs12663447 chr6:135317026 A/C cg24558204 chr6:135376177 HBS1L 0.72 10.08 0.53 1.92e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs12618769 0.597 rs55978998 chr2:99049014 A/G cg10123293 chr2:99228465 UNC50 0.41 5.42 0.32 1.31e-7 Bipolar disorder; CESC cis rs5769765 0.908 rs2319464 chr22:50265777 A/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 9.11e-8 Schizophrenia; CESC cis rs4849845 0.637 rs4077564 chr2:121004241 C/T cg24070213 chr2:121070622 NA 0.43 6.21 0.36 1.98e-9 Mean platelet volume; CESC cis rs9291683 0.526 rs6827785 chr4:10018205 C/T cg02734326 chr4:10020555 SLC2A9 0.42 5.76 0.33 2.3e-8 Bone mineral density; CESC cis rs7666738 0.515 rs13142498 chr4:98792443 G/T cg17366294 chr4:99064904 C4orf37 0.5 6.19 0.36 2.34e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg11644478 chr21:40555479 PSMG1 -0.55 -7.42 -0.41 1.55e-12 Menarche (age at onset); CESC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg14703610 chr5:56206110 C5orf35 0.4 5.05 0.3 8.23e-7 Coronary artery disease; CESC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg11965913 chr1:205819406 PM20D1 0.44 6.18 0.35 2.43e-9 Prostate-specific antigen levels; CESC cis rs11190604 1.000 rs2495751 chr10:102327260 A/G cg07080220 chr10:102295463 HIF1AN 0.58 5.48 0.32 9.69e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7089973 0.872 rs7072364 chr10:116620840 G/A cg23260525 chr10:116636907 FAM160B1 0.38 6.35 0.36 9.27e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16102063 chr8:22298240 PPP3CC 0.53 6.37 0.36 8.43e-10 Gut microbiome composition (summer); CESC cis rs17376456 0.825 rs10476590 chr5:93244884 A/T cg25358565 chr5:93447407 FAM172A 1.13 10.1 0.53 1.69e-20 Diabetic retinopathy; CESC cis rs9549328 0.800 rs9549619 chr13:113632620 C/G cg16421871 chr13:113634978 MCF2L -0.35 -5.05 -0.3 8.26e-7 Systolic blood pressure; CESC cis rs9894429 0.646 rs6565612 chr17:79602820 C/T cg21984481 chr17:79567631 NPLOC4 0.34 5.22 0.31 3.67e-7 Eye color traits; CESC trans rs208520 0.874 rs208517 chr6:66947040 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.86 -9.95 -0.52 5.07e-20 Exhaled nitric oxide output; CESC cis rs12137294 0.866 rs1172140 chr1:205213024 G/A cg21643547 chr1:205240462 TMCC2 -0.34 -5.46 -0.32 1.11e-7 Red cell distribution width; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01002995 chr12:8185077 FOXJ2 -0.47 -6.32 -0.36 1.13e-9 Fibrinogen levels; CESC cis rs1559088 0.847 rs8110181 chr19:33605939 G/A cg27124370 chr19:33622961 WDR88 0.42 5.49 0.32 9.52e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg13206674 chr6:150067644 NUP43 0.43 6.18 0.35 2.39e-9 Lung cancer; CESC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg11644478 chr21:40555479 PSMG1 1.03 16.67 0.72 3.67e-43 Cognitive function; CESC cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC cis rs1878931 0.507 rs1218762 chr16:3405986 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.7 -8.77 -0.47 2.28e-16 Body mass index (adult); CESC cis rs11030122 0.661 rs12290747 chr11:3939650 T/C cg18678763 chr11:4115507 RRM1 -0.44 -5.84 -0.34 1.54e-8 Mean platelet volume;Platelet distribution width; CESC cis rs7432375 0.610 rs4420814 chr3:136513282 T/C cg15507776 chr3:136538369 TMEM22 0.6 7.81 0.43 1.32e-13 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs2952156 0.883 rs907089 chr17:37833600 C/T cg20243544 chr17:37824526 PNMT 0.6 7.8 0.43 1.39e-13 Asthma; CESC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Depression; CESC cis rs2710642 0.721 rs6545969 chr2:62891474 C/T cg17519650 chr2:63277830 OTX1 -0.56 -6.88 -0.39 4.38e-11 LDL cholesterol levels;LDL cholesterol; CESC cis rs1577917 0.958 rs1591437 chr6:86525305 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.28 -0.36 1.4e-9 Response to antipsychotic treatment; CESC cis rs72781680 0.611 rs7596060 chr2:24334361 A/G cg20701182 chr2:24300061 SF3B14 -0.9 -10.4 -0.54 1.85e-21 Lymphocyte counts; CESC cis rs72781680 1.000 rs72798408 chr2:24181845 G/C cg20701182 chr2:24300061 SF3B14 0.79 6.83 0.39 5.75e-11 Lymphocyte counts; CESC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg11644478 chr21:40555479 PSMG1 1.08 17.93 0.74 1.24e-47 Cognitive function; CESC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 13.1 0.63 1.4e-30 Platelet count; CESC cis rs1348850 0.526 rs4893829 chr2:178399810 A/G cg23306229 chr2:178417860 TTC30B -0.78 -7.32 -0.41 2.88e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg18301423 chr5:131593218 PDLIM4 0.39 5.48 0.32 1.01e-7 Breast cancer; CESC cis rs3096299 0.748 rs2965822 chr16:89444677 A/T cg08392591 chr16:89556376 ANKRD11 0.43 5.42 0.32 1.34e-7 Multiple myeloma (IgH translocation); CESC cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg05283184 chr6:79620031 NA -0.44 -6.8 -0.39 6.74e-11 Intelligence (multi-trait analysis); CESC cis rs36051895 0.623 rs2146041 chr9:5262911 A/G cg02405213 chr9:5042618 JAK2 -0.52 -6.39 -0.37 7.54e-10 Pediatric autoimmune diseases; CESC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg12648201 chr2:27665141 KRTCAP3 -0.31 -5.65 -0.33 4.22e-8 Total body bone mineral density; CESC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg24846343 chr22:24311635 DDTL 0.63 10.71 0.55 1.71e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1874326 0.545 rs4626544 chr7:138110301 C/G cg18008034 chr7:138118925 NA -0.41 -5.14 -0.3 5.34e-7 Quantitative traits; CESC cis rs34779708 0.733 rs12243593 chr10:35549045 C/T cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs611744 0.647 rs579162 chr8:109254842 A/G cg21045802 chr8:109455806 TTC35 0.49 6.06 0.35 4.71e-9 Dupuytren's disease; CESC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg15664640 chr17:80829946 TBCD -0.64 -9.06 -0.49 2.98e-17 Breast cancer; CESC cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg05347473 chr6:146136440 FBXO30 0.57 7.3 0.41 3.36e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg11890956 chr21:40555474 PSMG1 1.16 21.87 0.8 2.81e-61 Cognitive function; CESC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg05481257 chr2:20870211 GDF7 -0.37 -5.62 -0.33 4.72e-8 Abdominal aortic aneurysm; CESC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg02592271 chr2:27665507 KRTCAP3 -0.3 -6.24 -0.36 1.77e-9 Total body bone mineral density; CESC cis rs9630089 0.521 rs4917761 chr10:98967236 C/T cg25902810 chr10:99078978 FRAT1 0.5 6.59 0.38 2.42e-10 Neutrophil percentage of white cells; CESC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg00310523 chr12:86230176 RASSF9 0.41 6.23 0.36 1.85e-9 Major depressive disorder; CESC cis rs1267303 0.682 rs1998545 chr1:46954587 C/T cg25110126 chr1:46999211 NA 0.49 5.59 0.32 5.63e-8 Monobrow; CESC cis rs3008870 1.000 rs3008848 chr1:67379284 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.05 14.57 0.67 9.8e-36 Lymphocyte percentage of white cells; CESC cis rs965469 1.000 rs965469 chr20:3381549 T/C cg25506879 chr20:3388711 C20orf194 -0.57 -6.1 -0.35 3.75e-9 IFN-related cytopenia; CESC cis rs67311347 1.000 rs1047855 chr3:40468896 A/G cg09455208 chr3:40491958 NA -0.5 -8.09 -0.45 2.09e-14 Renal cell carcinoma; CESC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg26850624 chr5:429559 AHRR -0.5 -6.67 -0.38 1.52e-10 Cystic fibrosis severity; CESC cis rs262150 0.819 rs6956589 chr7:158769301 C/T cg09640425 chr7:158790006 NA -0.35 -5.34 -0.31 1.98e-7 Facial morphology (factor 20); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17589437 chr7:87563717 ADAM22 0.45 6.3 0.36 1.24e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06335301 chr2:27593335 EIF2B4;SNX17 -0.49 -6.19 -0.36 2.22e-9 Ulcerative colitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25085038 chr20:3897636 PANK2;MIR103-2 0.41 6.46 0.37 5e-10 Gut microbiota (bacterial taxa); CESC cis rs9308731 0.583 rs4848406 chr2:111933758 G/A cg04202892 chr2:111875749 ACOXL 0.44 6.01 0.35 6.08e-9 Chronic lymphocytic leukemia; CESC cis rs3820068 0.581 rs6429762 chr1:15945595 A/C cg17385448 chr1:15911702 AGMAT 0.42 6.98 0.39 2.3e-11 Systolic blood pressure; CESC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg00800038 chr16:89945340 TCF25 -0.92 -7.62 -0.42 4.38e-13 Skin colour saturation; CESC cis rs644799 0.710 rs522536 chr11:95528714 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.76 10.93 0.56 3.47e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg11366901 chr6:160182831 ACAT2 0.75 9.02 0.48 3.9e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs1707322 1.000 rs4460583 chr1:46449918 C/G cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg05535760 chr7:792225 HEATR2 0.96 11.11 0.56 8.35e-24 Cerebrospinal P-tau181p levels; CESC cis rs9796 0.717 rs476633 chr15:41392134 C/G cg12426344 chr15:41135900 SPINT1 -0.23 -5.1 -0.3 6.58e-7 Menopause (age at onset); CESC cis rs611744 0.647 rs2848620 chr8:109249551 G/T cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.65e-8 Dupuytren's disease; CESC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg03188948 chr7:1209495 NA 0.72 6.98 0.39 2.42e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs9325144 0.534 rs1843866 chr12:38703160 G/T cg23762105 chr12:34175262 ALG10 -0.46 -6.24 -0.36 1.71e-9 Morning vs. evening chronotype; CESC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg24829409 chr8:58192753 C8orf71 -0.5 -6.08 -0.35 4.13e-9 Developmental language disorder (linguistic errors); CESC cis rs11920090 0.789 rs6785233 chr3:170756985 A/C cg09710316 chr3:170744871 SLC2A2 0.44 5.17 0.3 4.7e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs959260 1.000 rs4789180 chr17:73374396 G/T cg12999837 chr17:73267436 MIF4GD -0.51 -5.8 -0.34 1.91e-8 Systemic lupus erythematosus; CESC cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg19193384 chr17:30244184 NA -0.73 -6.87 -0.39 4.66e-11 Hip circumference adjusted for BMI; CESC trans rs35110281 0.776 rs229357 chr21:44982717 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 7.93 0.44 6.34e-14 Mean corpuscular volume; CESC cis rs13106227 0.602 rs9996922 chr4:77437749 G/A cg20311846 chr4:77356250 SHROOM3 -0.28 -5.2 -0.3 4.02e-7 Eosinophilic esophagitis (pediatric); CESC cis rs7605827 0.897 rs7586068 chr2:15596747 T/A cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC cis rs9818941 0.826 rs2673547 chr3:157646627 A/G cg08654915 chr3:157813417 NA 0.46 7.55 0.42 6.94e-13 Height; CESC cis rs8077889 0.956 rs4793025 chr17:41841621 T/C cg26893861 chr17:41843967 DUSP3 0.86 9.73 0.51 2.48e-19 Triglycerides; CESC cis rs4924935 1.000 rs4924935 chr17:18753870 C/T cg26378065 chr17:18585709 ZNF286B 0.46 5.85 0.34 1.43e-8 Pancreatic cancer; CESC cis rs28374715 0.681 rs7165396 chr15:41586947 T/C cg18705301 chr15:41695430 NDUFAF1 -1.0 -14.54 -0.67 1.34e-35 Ulcerative colitis; CESC cis rs11792861 0.816 rs3763643 chr9:111695607 T/C cg05043794 chr9:111880884 C9orf5 -0.37 -6.09 -0.35 3.98e-9 Menarche (age at onset); CESC cis rs35306767 0.951 rs55742421 chr10:961037 A/C cg20503657 chr10:835505 NA 0.9 9.27 0.49 6.58e-18 Eosinophil percentage of granulocytes; CESC cis rs2635047 0.811 rs10502880 chr18:44770746 T/C cg24371990 chr18:44770781 NA 0.43 6.98 0.39 2.42e-11 Educational attainment; CESC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.57 6.85 0.39 5.23e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03437924 chr16:25123326 LCMT1 0.69 8.2 0.45 1.05e-14 Gut microbiome composition (summer); CESC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.19 -0.53 8.64e-21 Alzheimer's disease; CESC cis rs12477438 0.501 rs13033012 chr2:99795149 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.75 12.51 0.61 1.6e-28 Chronic sinus infection; CESC cis rs8114671 0.836 rs17404569 chr20:33674077 A/C cg06115741 chr20:33292138 TP53INP2 -0.44 -5.31 -0.31 2.27e-7 Height; CESC cis rs4243830 0.850 rs1064835 chr1:6585539 A/G cg04093404 chr1:6614507 TAS1R1;NOL9 -0.56 -5.22 -0.31 3.57e-7 Body mass index; CESC cis rs2573652 0.722 rs12904962 chr15:100544113 A/G cg00587665 chr15:100533223 ADAMTS17 0.46 7.46 0.42 1.24e-12 Height; CESC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg16325326 chr1:53192061 ZYG11B -0.88 -14.93 -0.68 5.58e-37 Monocyte count; CESC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg18446336 chr7:2847575 GNA12 -0.35 -5.56 -0.32 6.7e-8 Height; CESC cis rs2070433 0.904 rs11701571 chr21:47963149 A/G cg12379764 chr21:47803548 PCNT 0.49 5.8 0.34 1.88e-8 Lymphocyte counts; CESC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg04025307 chr7:1156635 C7orf50 0.57 9.94 0.52 5.44e-20 Longevity;Endometriosis; CESC cis rs8067354 0.645 rs2271304 chr17:57814641 A/G cg02344993 chr17:57696989 CLTC 0.57 5.97 0.34 7.53e-9 Hemoglobin concentration; CESC cis rs116095464 0.558 rs10059907 chr5:205360 G/C cg22857025 chr5:266934 NA -1.28 -14.21 -0.66 1.88e-34 Breast cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19006050 chr10:131904236 NA -0.5 -6.86 -0.39 4.96e-11 Systemic lupus erythematosus; CESC cis rs8049040 0.547 rs12934168 chr16:71436778 C/T cg08717414 chr16:71523259 ZNF19 -0.62 -6.81 -0.39 6.39e-11 Blood protein levels; CESC cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg22143856 chr6:28129313 ZNF389 0.43 5.75 0.33 2.42e-8 Depression; CESC cis rs36051895 0.632 rs12337480 chr9:5134567 T/A cg02405213 chr9:5042618 JAK2 -0.47 -5.85 -0.34 1.42e-8 Pediatric autoimmune diseases; CESC cis rs2235642 0.928 rs56289115 chr16:1608934 A/G cg08296037 chr16:1584118 IFT140;TMEM204 -0.32 -5.22 -0.31 3.65e-7 Coronary artery disease; CESC cis rs3740540 0.530 rs2362503 chr10:126290538 T/C cg04949429 chr10:126290192 LHPP 0.39 5.48 0.32 9.85e-8 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs28489187 0.558 rs12044537 chr1:85846385 T/A cg16011679 chr1:85725395 C1orf52 0.44 5.28 0.31 2.69e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 9.41 0.5 2.44e-18 Platelet count; CESC cis rs11608355 0.545 rs7315846 chr12:109908617 T/C cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs12464559 0.649 rs3922996 chr2:152609668 A/G cg01189475 chr2:152685088 ARL5A 0.66 5.57 0.32 6.29e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs9354308 0.933 rs2802064 chr6:66564352 C/T cg07460842 chr6:66804631 NA 0.67 7.56 0.42 6.71e-13 Metabolite levels; CESC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg24675658 chr1:53192096 ZYG11B 0.6 7.55 0.42 7.08e-13 Monocyte count; CESC cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg05283184 chr6:79620031 NA 0.36 5.48 0.32 9.88e-8 Intelligence (multi-trait analysis); CESC cis rs11785693 0.862 rs11786657 chr8:5001792 T/C cg26367366 chr8:4980734 NA 0.79 7.56 0.42 6.43e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs7264396 0.563 rs2425084 chr20:34301871 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -10.76 -0.55 1.24e-22 Total cholesterol levels; CESC cis rs6570726 0.902 rs396681 chr6:145853603 T/C cg23711669 chr6:146136114 FBXO30 0.79 11.44 0.57 6.96e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 10.07 0.53 2.09e-20 Alzheimer's disease; CESC cis rs6456156 0.792 rs4710183 chr6:167514083 A/G cg23791538 chr6:167370224 RNASET2 0.42 5.52 0.32 8.27e-8 Primary biliary cholangitis; CESC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg07167872 chr1:205819463 PM20D1 0.76 12.12 0.6 3.34e-27 Menarche (age at onset); CESC cis rs60515486 0.702 rs11827106 chr11:47402615 G/A cg25783544 chr11:47291846 MADD 0.55 5.22 0.31 3.68e-7 Lymphocyte counts; CESC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg07701084 chr6:150067640 NUP43 0.41 5.83 0.34 1.57e-8 Lung cancer; CESC cis rs60843830 0.508 rs300750 chr2:208794 T/G cg25945732 chr2:264204 ACP1;SH3YL1 0.54 7.08 0.4 1.29e-11 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs55794721 0.509 rs6699896 chr1:25762902 A/T cg27572855 chr1:25598939 RHD 0.5 8.54 0.46 1.06e-15 Plateletcrit;Mean corpuscular volume; CESC trans rs73201076 0.915 rs7782005 chr7:111029564 C/T cg02312559 chr3:133973256 NA 0.52 6.02 0.35 5.69e-9 Schizophrenia; CESC cis rs5753618 0.504 rs9606846 chr22:31897571 C/T cg00478049 chr22:31556069 RNF185 -0.44 -5.17 -0.3 4.68e-7 Colorectal cancer; CESC cis rs7845219 0.544 rs4735332 chr8:95923660 C/T cg13393036 chr8:95962371 TP53INP1 -0.43 -8.22 -0.45 9.34e-15 Type 2 diabetes; CESC cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg02079420 chr8:82753780 SNX16 0.54 8.28 0.45 6.23e-15 Diastolic blood pressure; CESC cis rs1348850 0.632 rs12616288 chr2:178503813 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 7.43 0.42 1.54e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09754991 chr13:107220236 ARGLU1 -0.55 -6.34 -0.36 9.84e-10 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.44 0.37 5.54e-10 Prudent dietary pattern; CESC cis rs2708240 0.666 rs2710121 chr7:147608448 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.31 -5.13 -0.3 5.69e-7 QT interval (drug interaction); CESC cis rs2731664 0.792 rs466256 chr5:176875956 C/A cg23176889 chr5:176863531 GRK6 -0.63 -10.96 -0.56 2.69e-23 Intelligence (multi-trait analysis); CESC cis rs9300255 0.569 rs1716170 chr12:123716513 C/T cg19016782 chr12:123741754 C12orf65 -0.5 -7.1 -0.4 1.18e-11 Neutrophil percentage of white cells; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg16538604 chr4:2010703 WHSC2 0.46 6.2 0.36 2.11e-9 Bronchopulmonary dysplasia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05843257 chr22:24951377 SNRPD3;C22orf13 -0.48 -6.53 -0.37 3.26e-10 Gut microbiota (bacterial taxa); CESC cis rs9303280 0.868 rs11650661 chr17:38026286 A/T cg19468946 chr17:37922297 IKZF3 -0.43 -5.85 -0.34 1.48e-8 Self-reported allergy; CESC cis rs763121 0.853 rs2072794 chr22:39150543 G/T cg14440974 chr22:39074834 NA -0.4 -5.38 -0.31 1.62e-7 Menopause (age at onset); CESC cis rs7208859 0.673 rs73263981 chr17:28920502 A/G cg19761014 chr17:28927070 LRRC37B2 0.79 7.21 0.4 6.02e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14022721 chr22:25507536 KIAA1671 0.47 6.0 0.35 6.42e-9 Gut microbiota (bacterial taxa); CESC cis rs3806843 1.000 rs3733708 chr5:140181734 A/G cg26395211 chr5:140044315 WDR55 -0.42 -5.35 -0.31 1.9e-7 Depressive symptoms (multi-trait analysis); CESC trans rs1814175 0.935 rs11040462 chr11:49683158 G/A cg15704280 chr7:45808275 SEPT13 -0.99 -17.45 -0.73 6.22e-46 Height; CESC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.54 -0.32 7.22e-8 Total body bone mineral density; CESC cis rs3820068 0.705 rs4646083 chr1:15825564 G/A cg18192808 chr1:15853278 DNAJC16 0.47 5.66 0.33 3.93e-8 Systolic blood pressure; CESC cis rs6582630 0.622 rs11182004 chr12:38441254 G/A cg26384229 chr12:38710491 ALG10B -0.44 -5.95 -0.34 8.28e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs636291 0.517 rs55935829 chr1:10540926 A/T cg20482658 chr1:10539492 PEX14 -0.28 -5.88 -0.34 1.26e-8 Prostate cancer; CESC cis rs372883 0.638 rs117213 chr21:30720536 G/A cg08807101 chr21:30365312 RNF160 -0.45 -5.18 -0.3 4.41e-7 Pancreatic cancer; CESC cis rs6449957 0.639 rs251397 chr5:67508511 A/G cg23036683 chr5:67512108 NA 0.42 5.65 0.33 4.21e-8 Cleft lip with or without cleft palate; CESC cis rs9291683 0.530 rs35908990 chr4:9976105 G/A cg11266682 chr4:10021025 SLC2A9 0.61 12.55 0.61 1.12e-28 Bone mineral density; CESC cis rs965513 1.000 rs1588635 chr9:100537802 A/C cg13688889 chr9:100608707 NA -0.55 -7.58 -0.42 5.9e-13 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC trans rs4716602 0.609 rs12386633 chr7:156158232 G/C cg07175507 chr18:77160758 NFATC1 -0.45 -6.14 -0.35 3e-9 Anti-saccade response; CESC cis rs4595586 0.545 rs12810822 chr12:39391807 T/A cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs9549367 0.789 rs912012 chr13:113886152 G/A cg00898013 chr13:113819073 PROZ -0.52 -7.24 -0.41 4.75e-12 Platelet distribution width; CESC cis rs290986 0.812 rs290258 chr9:93555739 A/G cg02608019 chr9:93564028 SYK 0.52 5.65 0.33 4.09e-8 Multiple sclerosis; CESC trans rs7752903 0.793 rs2230926 chr6:138196066 T/G cg02519892 chr21:43198586 NA 0.77 6.35 0.36 9.56e-10 Rheumatoid arthritis; CESC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg06221963 chr1:154839813 KCNN3 -0.62 -10.54 -0.54 6.47e-22 Prostate cancer; CESC cis rs3761218 1.000 rs4815603 chr20:3772527 A/T cg25011176 chr20:3776985 CDC25B -0.45 -5.71 -0.33 3.03e-8 Bipolar disorder; CESC cis rs796364 1.000 rs281763 chr2:200794870 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.9 9.29 0.5 5.66e-18 Schizophrenia; CESC cis rs1580019 0.587 rs10951338 chr7:32560089 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 19.17 0.76 5.81e-52 Cognitive ability; CESC trans rs7726839 0.794 rs10053310 chr5:595661 C/G cg25482853 chr8:67687455 SGK3 0.62 6.37 0.36 8.09e-10 Obesity-related traits; CESC cis rs2072499 0.833 rs2251636 chr1:156202809 G/C cg25208724 chr1:156163844 SLC25A44 0.88 14.86 0.67 9.92e-37 Testicular germ cell tumor; CESC cis rs67311347 1.000 rs9860162 chr3:40403875 C/T cg09455208 chr3:40491958 NA 0.52 8.86 0.48 1.19e-16 Renal cell carcinoma; CESC cis rs1030268 0.651 rs13222377 chr7:133466346 C/T cg10665199 chr7:133106180 EXOC4 0.56 5.89 0.34 1.14e-8 Intelligence (multi-trait analysis); CESC cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg08564027 chr20:61660810 NA 0.9 15.37 0.69 1.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs10832963 1.000 rs10128711 chr11:18632984 A/G cg09201001 chr11:18656081 SPTY2D1 0.81 12.28 0.6 9.56e-28 Breast cancer; CESC cis rs9815354 0.537 rs73073272 chr3:42022446 G/A cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs12971120 0.891 rs3794955 chr18:72174827 C/T cg26446133 chr18:72167187 CNDP2 -0.77 -9.6 -0.51 6.53e-19 Refractive error; CESC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg02461776 chr11:598696 PHRF1 0.49 5.54 0.32 7.46e-8 Systemic lupus erythematosus; CESC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg04369109 chr6:150039330 LATS1 -0.42 -5.86 -0.34 1.34e-8 Lung cancer; CESC cis rs10838687 1.000 rs6485751 chr11:47336442 G/C cg25783544 chr11:47291846 MADD 0.59 7.37 0.41 2.23e-12 Proinsulin levels; CESC cis rs9300255 0.602 rs1402274 chr12:123686224 T/C cg00376283 chr12:123451042 ABCB9 0.71 8.92 0.48 7.69e-17 Neutrophil percentage of white cells; CESC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.88 0.34 1.2e-8 Bipolar disorder; CESC cis rs11711311 1.000 rs28394480 chr3:113485143 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.73 10.31 0.54 3.51e-21 IgG glycosylation; CESC cis rs7202877 0.706 rs4888393 chr16:75413673 C/T cg04384234 chr16:75411784 CFDP1 -0.49 -5.89 -0.34 1.16e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg22834771 chr12:69754056 YEATS4 -0.48 -6.46 -0.37 4.87e-10 Blood protein levels; CESC cis rs61931739 0.500 rs56056630 chr12:34543465 T/C cg06521331 chr12:34319734 NA -0.36 -5.03 -0.3 9.01e-7 Morning vs. evening chronotype; CESC cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg09035930 chr12:129282057 SLC15A4 0.68 9.0 0.48 4.39e-17 Systemic lupus erythematosus; CESC cis rs1018836 0.770 rs13266461 chr8:91652817 T/C cg16814680 chr8:91681699 NA -0.85 -12.78 -0.62 1.85e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs911555 0.723 rs11160751 chr14:103925740 T/C cg12935359 chr14:103987150 CKB -0.6 -8.57 -0.47 8.78e-16 Intelligence (multi-trait analysis); CESC cis rs3780486 0.846 rs10116966 chr9:33122370 T/A cg13443165 chr9:33130375 B4GALT1 0.44 6.45 0.37 5.18e-10 IgG glycosylation; CESC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg03806693 chr22:41940476 POLR3H -1.25 -17.05 -0.72 1.64e-44 Vitiligo; CESC trans rs10242455 0.850 rs57367781 chr7:99116819 G/A cg09045935 chr12:6379348 NA 0.91 7.48 0.42 1.07e-12 Blood metabolite levels; CESC cis rs7264396 0.690 rs2425178 chr20:34446395 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.36 0.41 2.25e-12 Total cholesterol levels; CESC cis rs9894429 1.000 rs9748176 chr17:79584043 C/G cg21984481 chr17:79567631 NPLOC4 -0.49 -8.01 -0.44 3.72e-14 Eye color traits; CESC cis rs2108622 0.727 rs12610189 chr19:15978641 T/G cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs2380220 0.808 rs2613548 chr6:95910559 C/T cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg18032046 chr6:28092343 ZSCAN16 0.6 6.89 0.39 4.02e-11 Parkinson's disease; CESC cis rs9300255 0.537 rs1790101 chr12:123704844 T/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.55 -0.37 2.97e-10 Neutrophil percentage of white cells; CESC trans rs5756813 0.754 rs4821711 chr22:38181115 C/T cg19894588 chr14:64061835 NA -0.65 -8.27 -0.45 6.52e-15 Optic cup area;Vertical cup-disc ratio; CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg18110333 chr6:292329 DUSP22 0.75 10.08 0.53 1.99e-20 Menopause (age at onset); CESC cis rs239198 0.602 rs9377236 chr6:101289960 A/G cg09795085 chr6:101329169 ASCC3 0.41 5.08 0.3 7.23e-7 Menarche (age at onset); CESC cis rs9488822 0.596 rs6568921 chr6:116373616 C/T cg15226275 chr6:116381976 FRK 0.23 5.6 0.33 5.22e-8 Cholesterol, total;LDL cholesterol; CESC cis rs7640424 0.680 rs68147515 chr3:107903216 T/A cg09227934 chr3:107805635 CD47 -0.45 -5.82 -0.34 1.66e-8 Body mass index; CESC cis rs7914558 1.000 rs943038 chr10:104826261 T/C cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.49e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg07694864 chr17:40700509 NA -0.47 -6.8 -0.39 6.95e-11 Colorectal or endometrial cancer; CESC cis rs55692468 0.540 rs4664586 chr2:153324071 C/T cg04681845 chr2:153283485 FMNL2 -0.27 -5.56 -0.32 6.54e-8 Intraocular pressure; CESC cis rs990171 0.607 rs10153578 chr2:102764609 C/T cg22835712 chr2:102737379 NA -0.44 -6.12 -0.35 3.29e-9 Lymphocyte counts; CESC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg02807482 chr3:125708958 NA -0.4 -5.2 -0.3 3.94e-7 Blood pressure (smoking interaction); CESC cis rs4242434 0.672 rs10099266 chr8:22484268 C/G cg03733263 chr8:22462867 KIAA1967 0.72 10.31 0.54 3.52e-21 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg04170460 chr16:29985301 TAOK2 -0.44 -6.53 -0.37 3.26e-10 Vertical cup-disc ratio; CESC cis rs2243480 1.000 rs13220979 chr7:65363204 G/A cg13147721 chr7:65941812 NA -0.83 -7.97 -0.44 4.85e-14 Diabetic kidney disease; CESC cis rs2361718 0.564 rs2304844 chr17:78084507 G/C cg23534315 chr17:78082725 GAA 0.4 5.7 0.33 3.12e-8 Yeast infection; CESC cis rs79349575 0.749 rs519537 chr17:46971140 G/A cg26022315 chr17:47021804 SNF8 0.38 5.04 0.3 8.49e-7 Type 2 diabetes; CESC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs854765 0.647 rs2056842 chr17:18009028 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.19 0.36 2.29e-9 Total body bone mineral density; CESC cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg11644478 chr21:40555479 PSMG1 -0.55 -7.39 -0.41 1.87e-12 Menarche (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03812994 chr10:81205453 ZCCHC24 0.47 6.34 0.36 1.01e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7429990 0.965 rs7426976 chr3:48022573 A/C cg11946769 chr3:48343235 NME6 -0.43 -5.2 -0.3 4e-7 Educational attainment (years of education); CESC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 0.48 5.43 0.32 1.3e-7 IgG glycosylation; CESC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg01416388 chr22:39784598 NA -0.58 -7.11 -0.4 1.1e-11 Intelligence (multi-trait analysis); CESC cis rs258892 0.793 rs61141607 chr5:72056883 T/A cg21869765 chr5:72125136 TNPO1 -0.42 -5.24 -0.31 3.2e-7 Small cell lung carcinoma; CESC cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg17724175 chr1:150552817 MCL1 -0.33 -5.23 -0.31 3.42e-7 Tonsillectomy; CESC cis rs6835098 1.000 rs1054497 chr4:174089048 A/T cg08422745 chr4:174089978 GALNT7 0.82 11.84 0.59 3.06e-26 Dementia and core Alzheimer's disease neuropathologic changes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05089059 chr7:128049863 IMPDH1 0.56 6.06 0.35 4.63e-9 Gut microbiome composition (summer); CESC cis rs11229555 1.000 rs12787765 chr11:58400686 G/A cg15696309 chr11:58395628 NA -0.44 -5.72 -0.33 2.82e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC trans rs35110281 0.720 rs162375 chr21:44927015 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.51 -6.94 -0.39 3.1e-11 Mean corpuscular volume; CESC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg02187348 chr16:89574699 SPG7 0.65 8.91 0.48 8.14e-17 Multiple myeloma (IgH translocation); CESC cis rs2191566 0.664 rs7255512 chr19:44574700 C/T cg20607764 chr19:44506953 ZNF230 -0.49 -6.34 -0.36 9.61e-10 Acute lymphoblastic leukemia (childhood); CESC trans rs12310956 0.532 rs1352209 chr12:33983408 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.64 0.38 1.82e-10 Morning vs. evening chronotype; CESC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.19 0.3 4.09e-7 Bipolar disorder; CESC cis rs6121246 0.567 rs6120879 chr20:30202961 T/C cg13852791 chr20:30311386 BCL2L1 0.57 5.29 0.31 2.54e-7 Mean corpuscular hemoglobin; CESC cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg24450063 chr1:156163899 SLC25A44 1.11 23.64 0.82 3.21e-67 Testicular germ cell tumor; CESC cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg18252515 chr7:66147081 NA -1.25 -12.55 -0.61 1.18e-28 Diabetic kidney disease; CESC cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.65 7.91 0.44 7.12e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs7851660 0.874 rs1955143 chr9:100634579 A/T cg13688889 chr9:100608707 NA -0.61 -8.52 -0.46 1.22e-15 Strep throat; CESC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg26335602 chr6:28129616 ZNF389 0.53 6.75 0.38 9.35e-11 Depression; CESC cis rs7605827 0.930 rs7605274 chr2:15604269 A/T cg19274914 chr2:15703543 NA 0.35 6.11 0.35 3.48e-9 Educational attainment (years of education); CESC cis rs11792861 0.962 rs3750454 chr9:111801325 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.44 -5.54 -0.32 7.28e-8 Menarche (age at onset); CESC cis rs1153858 0.943 rs12439575 chr15:45684816 T/G cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs17376456 1.000 rs34013242 chr5:93507947 C/T cg25358565 chr5:93447407 FAM172A 1.16 11.25 0.57 2.83e-24 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20786061 chr20:48429238 SLC9A8 0.63 7.46 0.42 1.25e-12 Gut microbiome composition (summer); CESC cis rs10838687 0.736 rs2242262 chr11:47266540 G/T cg25783544 chr11:47291846 MADD 0.57 6.63 0.38 1.91e-10 Proinsulin levels; CESC cis rs1048257 0.553 rs2819421 chr14:105408811 A/G cg19901468 chr14:105411992 AHNAK2 -0.62 -8.9 -0.48 8.75e-17 Systemic lupus erythematosus; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg00543632 chr16:19098067 NA -0.45 -6.18 -0.35 2.38e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs644148 0.676 rs2571114 chr19:44997579 A/G cg15540054 chr19:45004280 ZNF180 -0.46 -5.59 -0.33 5.51e-8 Personality dimensions; CESC cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg04681579 chr7:75027559 TRIM73;TRIM74 -0.55 -7.62 -0.42 4.45e-13 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9287719 0.967 rs10191883 chr2:10744136 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26643908 chr2:36825150 FEZ2 0.57 6.14 0.35 2.94e-9 Gut microbiome composition (summer); CESC cis rs9457247 0.765 rs10946203 chr6:167446735 A/C cg23791538 chr6:167370224 RNASET2 -0.55 -7.59 -0.42 5.54e-13 Crohn's disease; CESC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg11663144 chr21:46675770 NA -0.49 -6.41 -0.37 6.74e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg19257562 chr1:2043853 PRKCZ 0.41 6.62 0.38 1.99e-10 Height; CESC cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg22875332 chr1:76189707 ACADM 0.57 5.63 0.33 4.52e-8 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11110978 chr21:44527518 U2AF1 0.53 6.16 0.35 2.7e-9 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25124639 chr7:23221621 NUPL2 -0.39 -6.14 -0.35 2.96e-9 Gambling; CESC cis rs12477438 0.798 rs17708218 chr2:99696284 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.69 -0.55 2.12e-22 Chronic sinus infection; CESC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg22105103 chr4:187893119 NA 0.52 7.81 0.43 1.36e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs1814175 0.754 rs10219245 chr11:49645052 C/T cg15704280 chr7:45808275 SEPT13 -1.04 -20.29 -0.78 7.14e-56 Height; CESC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.75e-12 Tonsillectomy; CESC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.69 0.33 3.35e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7552167 0.925 rs11249021 chr1:24512881 G/T cg01960748 chr1:24522592 NA -0.4 -5.41 -0.32 1.41e-7 Psoriasis vulgaris; CESC cis rs977987 0.806 rs7199132 chr16:75450039 C/T cg03315344 chr16:75512273 CHST6 0.41 5.81 0.34 1.79e-8 Dupuytren's disease; CESC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg27170947 chr2:26402098 FAM59B 0.83 8.97 0.48 5.73e-17 Gut microbiome composition (summer); CESC cis rs17539620 0.624 rs117591255 chr6:154839118 G/A cg17771515 chr6:154831774 CNKSR3 0.58 5.76 0.33 2.36e-8 Lipoprotein (a) levels; CESC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.04 0.4 1.62e-11 Intelligence (multi-trait analysis); CESC cis rs67311347 0.956 rs9822870 chr3:40514890 A/C cg24209194 chr3:40518798 ZNF619 -0.57 -7.68 -0.43 3.11e-13 Renal cell carcinoma; CESC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg19717773 chr7:2847554 GNA12 -0.44 -6.46 -0.37 4.99e-10 Height; CESC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg17971929 chr21:40555470 PSMG1 0.86 12.56 0.61 1.07e-28 Cognitive function; CESC cis rs8040855 0.597 rs12902942 chr15:85584804 C/T cg08123816 chr15:85640762 PDE8A -0.38 -5.51 -0.32 8.51e-8 Bulimia nervosa; CESC trans rs8073060 0.561 rs225260 chr17:33958422 T/C cg19694781 chr19:47549865 TMEM160 -0.77 -7.47 -0.42 1.14e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Tonsillectomy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05112967 chr7:63353492 NA -0.49 -6.99 -0.39 2.28e-11 Gut microbiota (bacterial taxa); CESC cis rs7130144 0.541 rs79187796 chr11:130461670 G/A cg26307797 chr11:130446613 NA -0.83 -5.92 -0.34 1e-8 Urate levels in lean individuals; CESC cis rs1355223 0.583 rs1828298 chr11:34870439 A/G cg11058730 chr11:34937778 PDHX;APIP 0.82 12.62 0.61 6.79e-29 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs72781680 0.898 rs56413706 chr2:24086961 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.93 0.39 3.11e-11 Lymphocyte counts; CESC cis rs6964587 0.967 rs2282969 chr7:91583772 T/C cg17063962 chr7:91808500 NA -0.59 -7.86 -0.43 9.61e-14 Breast cancer; CESC cis rs2625529 0.761 rs4776582 chr15:72207520 A/T cg16672083 chr15:72433130 SENP8 -0.39 -5.09 -0.3 6.78e-7 Red blood cell count; CESC cis rs4642101 0.824 rs9835677 chr3:12845158 G/A cg05775895 chr3:12838266 CAND2 0.39 5.78 0.33 2.1e-8 QRS complex (12-leadsum); CESC cis rs7617773 0.817 rs936426 chr3:48215253 C/T cg11946769 chr3:48343235 NME6 0.77 10.19 0.53 8.62e-21 Coronary artery disease; CESC cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg05347473 chr6:146136440 FBXO30 0.57 7.3 0.41 3.36e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7188697 0.769 rs9932944 chr16:58616165 C/T cg02549819 chr16:58548995 SETD6 0.44 5.4 0.31 1.47e-7 QT interval; CESC cis rs7246657 0.941 rs67293224 chr19:37803248 C/T cg23950597 chr19:37808831 NA -0.63 -6.43 -0.37 5.83e-10 Coronary artery calcification; CESC cis rs763014 0.931 rs710925 chr16:633354 G/A cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.28 0.31 2.75e-7 Menopause (age at onset); CESC cis rs28374715 0.532 rs7164211 chr15:41705041 A/T cg18705301 chr15:41695430 NDUFAF1 -1.01 -16.07 -0.7 5.07e-41 Ulcerative colitis; CESC cis rs7727544 0.735 rs272884 chr5:131668654 G/C cg24060327 chr5:131705240 SLC22A5 -0.67 -8.93 -0.48 7.2e-17 Blood metabolite levels; CESC cis rs10089 1.000 rs6595806 chr5:127499764 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.74 9.81 0.52 1.39e-19 Ileal carcinoids; CESC cis rs2739330 0.892 rs5751776 chr22:24266954 A/C cg01238044 chr22:24384105 GSTT1 -0.58 -7.42 -0.41 1.63e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7953508 0.506 rs1316740 chr12:93968288 C/A cg18151635 chr12:93972918 NA -0.44 -5.89 -0.34 1.19e-8 Pubertal anthropometrics; CESC cis rs714031 1.000 rs5757765 chr22:40067840 T/C cg21377881 chr22:40064566 CACNA1I -0.33 -5.26 -0.31 2.96e-7 Schizophrenia; CESC cis rs6867032 0.834 rs4526149 chr5:1990166 G/A cg26168224 chr5:2018326 NA -0.79 -11.78 -0.59 4.84e-26 Gut microbiome composition (winter); CESC cis rs3747547 1.000 rs72724195 chr9:37948063 C/T cg13774184 chr9:37916125 SHB -0.74 -6.3 -0.36 1.24e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs1372520 0.684 rs184810 chr4:90697979 T/C cg15133208 chr4:90757351 SNCA 0.42 5.4 0.31 1.5e-7 Neuroticism; CESC cis rs2204008 0.547 rs12318267 chr12:38250905 T/G cg26384229 chr12:38710491 ALG10B -0.44 -5.73 -0.33 2.66e-8 Bladder cancer; CESC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg11494091 chr17:61959527 GH2 0.73 12.58 0.61 8.77e-29 Prudent dietary pattern; CESC cis rs7116495 1.000 rs73543609 chr11:71816619 G/T cg10381502 chr11:71823885 C11orf51 0.66 5.35 0.31 1.93e-7 Severe influenza A (H1N1) infection; CESC cis rs60515486 0.527 rs56756748 chr11:47392568 C/G cg25783544 chr11:47291846 MADD 0.54 5.26 0.31 2.91e-7 Lymphocyte counts; CESC cis rs10028773 0.666 rs12498657 chr4:120262866 G/C cg09307838 chr4:120376055 NA 0.76 10.02 0.52 3.03e-20 Educational attainment; CESC cis rs28374715 0.783 rs11630656 chr15:41570909 T/G cg18705301 chr15:41695430 NDUFAF1 -0.98 -14.25 -0.66 1.37e-34 Ulcerative colitis; CESC cis rs3820068 0.705 rs11583306 chr1:15860803 A/G cg17385448 chr1:15911702 AGMAT -0.38 -5.87 -0.34 1.28e-8 Systolic blood pressure; CESC cis rs8141529 0.732 rs2347447 chr22:29179739 C/A cg15103426 chr22:29168792 CCDC117 0.7 9.86 0.52 9.91e-20 Lymphocyte counts; CESC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg02725872 chr8:58115012 NA -0.45 -7.07 -0.4 1.39e-11 Developmental language disorder (linguistic errors); CESC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg25072359 chr17:41440525 NA 0.47 6.39 0.37 7.42e-10 Menopause (age at onset); CESC cis rs11608355 0.545 rs6606721 chr12:109891999 G/A cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs3213545 0.659 rs2259693 chr12:121457995 G/A cg25281562 chr12:121454272 C12orf43 0.45 5.69 0.33 3.3e-8 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs9457247 0.663 rs10946205 chr6:167451311 A/G cg07741184 chr6:167504864 NA 0.35 6.27 0.36 1.43e-9 Crohn's disease; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg03117951 chr6:57036288 BAG2 0.39 6.0 0.35 6.29e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs7615952 0.800 rs35390120 chr3:125599809 G/A cg07211511 chr3:129823064 LOC729375 -0.87 -8.85 -0.48 1.28e-16 Blood pressure (smoking interaction); CESC cis rs9039 0.921 rs9929699 chr16:9218270 A/G cg08831531 chr16:9218945 NA -0.41 -6.21 -0.36 2.05e-9 Menopause (age at onset); CESC cis rs7089973 0.604 rs2420065 chr10:116583753 A/G cg25233709 chr10:116636983 FAM160B1 0.35 5.47 0.32 1.05e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6831352 0.918 rs13113166 chr4:100050528 A/G cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03550773 chr14:35163458 NA -0.65 -7.71 -0.43 2.58e-13 Gut microbiome composition (summer); CESC cis rs10028773 0.632 rs34481394 chr4:120248374 C/T cg09307838 chr4:120376055 NA 0.74 9.42 0.5 2.28e-18 Educational attainment; CESC cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg05347473 chr6:146136440 FBXO30 0.58 7.53 0.42 7.78e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs77106637 0.932 rs74439784 chr11:72649396 A/T cg04827223 chr11:72435913 ARAP1 -0.49 -5.27 -0.31 2.9e-7 Type 2 diabetes; CESC trans rs11039798 0.844 rs7126949 chr11:48972166 A/G cg15704280 chr7:45808275 SEPT13 0.7 6.56 0.37 2.74e-10 Axial length; CESC cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg01181863 chr3:195395398 SDHAP2 -0.48 -5.71 -0.33 3.03e-8 Pancreatic cancer; CESC cis rs34779708 0.742 rs35912711 chr10:35312996 T/C cg04310649 chr10:35416472 CREM -0.5 -5.97 -0.34 7.64e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9811920 0.609 rs809415 chr3:99582242 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.63 -10.11 -0.53 1.61e-20 Axial length; CESC cis rs67478160 0.619 rs2368560 chr14:104273311 C/T cg08213375 chr14:104286397 PPP1R13B 0.54 10.75 0.55 1.33e-22 Schizophrenia; CESC cis rs1729951 0.575 rs361245 chr3:136695706 A/G cg04103450 chr3:136751342 NA 0.4 5.3 0.31 2.45e-7 Neuroticism; CESC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg08736216 chr1:53307985 ZYG11A 0.37 6.02 0.35 5.92e-9 Monocyte count; CESC trans rs7824557 0.564 rs2572399 chr8:11234520 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.09 -0.35 3.85e-9 Retinal vascular caliber; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01307007 chr19:3522587 FZR1 0.49 6.6 0.38 2.27e-10 Fibrinogen levels; CESC cis rs35955747 0.633 rs5998002 chr22:31881169 A/G cg25791279 chr22:32026902 PISD -0.43 -5.11 -0.3 6.26e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs7808935 0.628 rs9791862 chr7:27950760 G/A cg05786569 chr7:27702416 HIBADH 0.53 5.94 0.34 8.97e-9 Prostate cancer; CESC cis rs11640533 1.000 rs11640533 chr16:53412862 A/G cg04653913 chr16:53407753 NA -0.43 -5.7 -0.33 3.13e-8 Intelligence (multi-trait analysis); CESC cis rs6674176 0.593 rs6675620 chr1:44417630 C/T cg12908607 chr1:44402522 ARTN -0.45 -6.45 -0.37 5.26e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1153858 1.000 rs4774577 chr15:45644685 A/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.45e-9 Homoarginine levels; CESC cis rs16910800 0.689 rs4491218 chr11:23163977 G/A cg20040320 chr11:23191996 NA -0.6 -5.41 -0.32 1.44e-7 Cancer; CESC cis rs977987 0.931 rs1424013 chr16:75495986 T/C cg03315344 chr16:75512273 CHST6 0.55 8.01 0.44 3.67e-14 Dupuytren's disease; CESC trans rs1144403 0.778 rs1147019 chr11:104591863 A/G cg05575375 chr4:3692375 NA 0.32 6.0 0.35 6.63e-9 Schizophrenia; CESC cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg17644776 chr2:200775616 C2orf69 0.47 5.65 0.33 4.16e-8 Osteoporosis; CESC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.44 -5.63 -0.33 4.53e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9796 0.870 rs2412574 chr15:41259707 G/C cg18705301 chr15:41695430 NDUFAF1 -0.47 -7.04 -0.4 1.61e-11 Menopause (age at onset); CESC cis rs3806843 0.676 rs2245640 chr5:140029958 A/G cg16179182 chr5:140090404 VTRNA1-1 0.42 5.35 0.31 1.9e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.32 0.31 2.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4700695 0.719 rs27079 chr5:65443966 C/T cg21114390 chr5:65439923 SFRS12 -0.5 -6.1 -0.35 3.72e-9 Facial morphology (factor 19); CESC cis rs660498 0.526 rs610451 chr10:27705152 A/G cg25705717 chr10:27608719 NA -0.47 -5.82 -0.34 1.66e-8 Asthma (childhood onset); CESC cis rs6060717 0.536 rs6060699 chr20:34523833 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.47 0.37 4.58e-10 Hip circumference adjusted for BMI; CESC cis rs6088580 0.634 rs6142157 chr20:32984172 C/G cg24642439 chr20:33292090 TP53INP2 -0.53 -6.97 -0.39 2.55e-11 Glomerular filtration rate (creatinine); CESC cis rs3008870 0.959 rs2815359 chr1:67494374 T/C cg02640540 chr1:67518911 SLC35D1 0.51 5.43 0.32 1.25e-7 Lymphocyte percentage of white cells; CESC cis rs7727544 0.684 rs274560 chr5:131719450 T/C cg24060327 chr5:131705240 SLC22A5 0.63 8.42 0.46 2.38e-15 Blood metabolite levels; CESC cis rs11958404 0.929 rs72816533 chr5:157413352 G/T cg05962755 chr5:157440814 NA 0.62 6.67 0.38 1.5e-10 IgG glycosylation; CESC cis rs644799 1.000 rs593665 chr11:95574302 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.53 0.46 1.12e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs858239 0.539 rs10247268 chr7:23187179 G/A cg23682824 chr7:23144976 KLHL7 0.46 5.85 0.34 1.45e-8 Cerebrospinal fluid biomarker levels; CESC cis rs11577318 0.853 rs17645 chr1:26646730 A/G cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.36 -0.36 8.77e-10 Granulocyte percentage of myeloid white cells; CESC cis rs67311347 1.000 rs17078941 chr3:40450888 A/G cg24209194 chr3:40518798 ZNF619 -0.46 -5.64 -0.33 4.35e-8 Renal cell carcinoma; CESC cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg13902645 chr11:5959945 NA -0.64 -7.67 -0.43 3.24e-13 DNA methylation (variation); CESC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg27297192 chr10:134578999 INPP5A 0.38 5.04 0.3 8.72e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs677673 1.000 rs62185061 chr20:10474918 A/G cg16021678 chr13:55475951 NA 0.51 6.4 0.37 7.15e-10 Body mass index (change over time) in chronic obstructive pulmonary disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01700524 chr14:24803014 ADCY4 0.55 6.34 0.36 9.64e-10 Gut microbiome composition (summer); CESC cis rs793571 0.505 rs9920042 chr15:58901396 C/T cg05156742 chr15:59063176 FAM63B 0.5 5.29 0.31 2.54e-7 Schizophrenia; CESC cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg20503657 chr10:835505 NA 1.09 9.82 0.52 1.29e-19 Eosinophil percentage of granulocytes; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg23131131 chr22:24373011 LOC391322 -0.64 -8.63 -0.47 5.78e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6754311 0.731 rs2236783 chr2:136594158 G/A cg07169764 chr2:136633963 MCM6 -0.71 -8.41 -0.46 2.56e-15 Mosquito bite size; CESC cis rs7267979 1.000 rs2482930 chr20:25334115 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -16.6 -0.71 6.43e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg27535305 chr1:53392650 SCP2 -0.32 -5.42 -0.32 1.34e-7 Monocyte count; CESC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg19077165 chr18:44547161 KATNAL2 0.6 8.8 0.48 1.75e-16 Personality dimensions; CESC cis rs60843830 0.928 rs2306060 chr2:230912 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.88 11.92 0.59 1.59e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.67 10.06 0.53 2.21e-20 Personality dimensions; CESC cis rs7116495 1.000 rs671681 chr11:71782812 T/C cg26138937 chr11:71823887 C11orf51 -0.84 -6.79 -0.38 7.37e-11 Severe influenza A (H1N1) infection; CESC cis rs3744061 0.557 rs9889902 chr17:74648034 T/C cg27546012 chr17:74684504 MXRA7 -0.39 -5.32 -0.31 2.23e-7 Retinal arteriolar caliber; CESC cis rs698813 0.572 rs12712914 chr2:44478649 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.53 0.32 7.62e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs367943 0.666 rs12332129 chr5:112977983 A/G cg12552261 chr5:112820674 MCC 0.4 5.19 0.3 4.14e-7 Type 2 diabetes; CESC cis rs6598955 0.515 rs61776655 chr1:26541430 T/C cg00852783 chr1:26633632 UBXN11 0.4 5.87 0.34 1.32e-8 Obesity-related traits; CESC cis rs3936840 1.000 rs3936840 chr14:102984274 G/C cg18135206 chr14:102964638 TECPR2 0.49 6.44 0.37 5.66e-10 Plateletcrit; CESC cis rs763121 0.925 rs9611008 chr22:39098787 T/C cg06544989 chr22:39130855 UNC84B 0.54 10.41 0.54 1.69e-21 Menopause (age at onset); CESC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg22920501 chr2:26401640 FAM59B 0.76 8.74 0.47 2.69e-16 Gut microbiome composition (summer); CESC cis rs523516 0.645 rs658589 chr17:37319293 T/C cg20555674 chr17:37321631 ARL5C 0.37 6.18 0.36 2.36e-9 IgG glycosylation; CESC trans rs11098499 0.644 rs10009566 chr4:120558608 A/G cg25214090 chr10:38739885 LOC399744 0.61 8.79 0.48 1.87e-16 Corneal astigmatism; CESC cis rs1878931 0.582 rs27225 chr16:3428060 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.68 -8.24 -0.45 8.01e-15 Body mass index (adult); CESC cis rs72945132 0.882 rs17425511 chr11:70183737 C/G cg14191688 chr11:70257035 CTTN 0.46 5.5 0.32 8.8e-8 Coronary artery disease; CESC trans rs7902708 0.920 rs7095115 chr10:54425442 G/A cg26219051 chr22:43739629 SCUBE1 -0.48 -6.07 -0.35 4.3e-9 Bone properties (heel); CESC cis rs11122272 0.766 rs2790870 chr1:231543823 A/G cg06096015 chr1:231504339 EGLN1 0.41 5.71 0.33 3e-8 Hemoglobin concentration; CESC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg18252515 chr7:66147081 NA -0.47 -6.41 -0.37 6.57e-10 Aortic root size; CESC cis rs17253792 0.822 rs10148983 chr14:56051879 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.86 6.17 0.35 2.52e-9 Putamen volume; CESC cis rs7845219 0.544 rs4570121 chr8:95917088 C/T cg09323728 chr8:95962352 TP53INP1 -0.33 -6.47 -0.37 4.66e-10 Type 2 diabetes; CESC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg08888203 chr3:10149979 C3orf24 0.5 6.33 0.36 1.05e-9 Alzheimer's disease; CESC cis rs2228479 0.850 rs11648689 chr16:89806732 G/A cg00800038 chr16:89945340 TCF25 -0.87 -7.07 -0.4 1.4e-11 Skin colour saturation; CESC cis rs858239 0.670 rs3807452 chr7:23162081 C/T cg23682824 chr7:23144976 KLHL7 -0.47 -6.62 -0.38 2.02e-10 Cerebrospinal fluid biomarker levels; CESC cis rs73206853 0.660 rs12313068 chr12:110597304 C/T cg12870014 chr12:110450643 ANKRD13A 0.66 6.93 0.39 3.27e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9303401 0.659 rs11079358 chr17:56920949 G/T cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.69 0.61 3.78e-29 Cognitive test performance; CESC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg02487422 chr3:49467188 NICN1 0.37 5.07 0.3 7.51e-7 Menarche (age at onset); CESC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg17724175 chr1:150552817 MCL1 0.42 6.45 0.37 5.2400000000000005e-10 Melanoma; CESC cis rs9911578 1.000 rs11870671 chr17:56605360 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04446112 chr11:64008349 FKBP2 0.6 6.59 0.38 2.4e-10 Gut microbiome composition (summer); CESC cis rs250677 0.687 rs40149 chr5:148444275 A/T cg18129178 chr5:148520854 ABLIM3 -0.53 -5.84 -0.34 1.53e-8 Breast cancer; CESC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.76 8.26 0.45 6.79e-15 Platelet count; CESC cis rs9309473 0.948 rs13391552 chr2:73818936 C/T cg20560298 chr2:73613845 ALMS1 -0.52 -6.85 -0.39 5.27e-11 Metabolite levels; CESC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg25319279 chr11:5960081 NA -0.38 -5.33 -0.31 2.06e-7 DNA methylation (variation); CESC cis rs921968 0.565 rs3755045 chr2:219609162 T/G cg02176678 chr2:219576539 TTLL4 -0.46 -8.23 -0.45 8.59e-15 Mean corpuscular hemoglobin concentration; CESC cis rs3812049 0.784 rs3749748 chr5:127350549 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.92 -11.49 -0.58 4.48e-25 Lymphocyte counts;Red cell distribution width; CESC cis rs7084402 0.967 rs1649091 chr10:60289440 T/A cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -6.97 -0.39 2.54e-11 Bipolar disorder; CESC cis rs870825 0.616 rs7678949 chr4:185635018 G/C cg04058563 chr4:185651563 MLF1IP 0.63 6.89 0.39 3.95e-11 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12592908 chr6:36954170 MTCH1 0.56 6.38 0.36 7.73e-10 Gut microbiome composition (summer); CESC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg08859206 chr1:53392774 SCP2 0.54 6.88 0.39 4.27e-11 Monocyte count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05310613 chr6:139456890 HECA 0.47 6.65 0.38 1.7e-10 Gut microbiota (bacterial taxa); CESC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg00129232 chr17:37814104 STARD3 0.53 6.84 0.39 5.58e-11 Glomerular filtration rate (creatinine); CESC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg24060327 chr5:131705240 SLC22A5 0.76 10.63 0.55 3.22e-22 Breast cancer; CESC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg00074818 chr8:8560427 CLDN23 0.37 5.43 0.32 1.26e-7 Obesity-related traits; CESC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6542838 0.641 rs6724477 chr2:99537074 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.48 6.02 0.35 5.76e-9 Fear of minor pain; CESC trans rs9467711 0.606 rs9366655 chr6:26377385 C/G cg06606381 chr12:133084897 FBRSL1 -0.71 -6.7 -0.38 1.27e-10 Autism spectrum disorder or schizophrenia; CESC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg12564285 chr5:131593104 PDLIM4 0.39 5.82 0.34 1.7e-8 Breast cancer; CESC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg06494592 chr3:125709126 NA -0.51 -5.44 -0.32 1.22e-7 Blood pressure (smoking interaction); CESC cis rs7208859 0.623 rs7220289 chr17:29103762 G/T cg13385521 chr17:29058706 SUZ12P 0.77 6.18 0.35 2.41e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs3780486 0.505 rs10758194 chr9:33157419 G/T cg20290983 chr6:43655470 MRPS18A 0.73 11.38 0.57 1.06e-24 IgG glycosylation; CESC cis rs7772486 0.654 rs702321 chr6:146006695 A/G cg05347473 chr6:146136440 FBXO30 -0.52 -6.6 -0.38 2.19e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05593479 chr2:233415006 TIGD1;EIF4E2 0.42 6.08 0.35 4.26e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs798766 1.000 rs7682402 chr4:1743343 G/A cg05874882 chr4:1763078 NA -0.57 -7.37 -0.41 2.15e-12 Bladder cancer;Urinary bladder cancer; CESC cis rs8077889 0.917 rs58283314 chr17:41905963 T/G cg26893861 chr17:41843967 DUSP3 0.74 9.46 0.5 1.75e-18 Triglycerides; CESC cis rs6582630 0.615 rs3914894 chr12:38480280 C/T cg26384229 chr12:38710491 ALG10B -0.43 -5.85 -0.34 1.44e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs16867321 0.639 rs12466864 chr2:181441417 C/G cg23363182 chr2:181467187 NA 0.47 6.99 0.39 2.17e-11 Obesity; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13497155 chr3:50374949 RASSF1 0.54 7.25 0.41 4.59e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9768139 0.733 rs13309408 chr7:158122261 C/T cg24154853 chr7:158122151 PTPRN2 0.4 6.09 0.35 3.98e-9 Calcium levels; CESC trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21659725 chr3:3221576 CRBN -0.82 -13.57 -0.64 3.35e-32 Intelligence (multi-trait analysis); CESC cis rs10870270 1.000 rs10870270 chr10:133754334 G/A cg08754478 chr10:133766260 PPP2R2D -0.59 -7.67 -0.43 3.19e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7432375 0.610 rs7633629 chr3:136517028 T/A cg15507776 chr3:136538369 TMEM22 0.6 8.0 0.44 3.8e-14 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs1843834 0.898 rs11887386 chr2:225526975 T/G cg22455342 chr2:225449267 CUL3 0.52 6.54 0.37 3.19e-10 IgE levels in asthmatics (D.p. specific); CESC cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 5.45 0.32 1.15e-7 Colorectal cancer; CESC cis rs67478160 0.575 rs8014294 chr14:104322983 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.52 -0.42 8.34e-13 Schizophrenia; CESC cis rs2274273 1.000 rs2274273 chr14:55614636 A/G cg04306507 chr14:55594613 LGALS3 -0.29 -5.36 -0.31 1.83e-7 Protein biomarker; CESC cis rs116095464 0.558 rs62346506 chr5:201594 T/C cg22496380 chr5:211416 CCDC127 -0.95 -10.44 -0.54 1.37e-21 Breast cancer; CESC cis rs7772486 0.727 rs12190966 chr6:146146820 T/G cg05347473 chr6:146136440 FBXO30 0.52 6.61 0.38 2.05e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg23708337 chr7:1209742 NA 0.54 5.4 0.31 1.48e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.02 0.59 7.31e-27 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26163375 chr1:1209720 UBE2J2 0.54 6.24 0.36 1.71e-9 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs2338755 chr17:37419317 C/T cg07936489 chr17:37558343 FBXL20 0.82 12.27 0.6 1.03e-27 Glomerular filtration rate (creatinine); CESC cis rs10927875 0.518 rs732286 chr1:16344360 A/G cg22431228 chr1:16359049 CLCNKA -0.52 -10.02 -0.52 3.09e-20 Dilated cardiomyopathy; CESC cis rs61008539 0.821 rs10950789 chr7:897492 A/G cg15782153 chr7:917662 C7orf20 0.47 6.79 0.38 7.35e-11 Perceived unattractiveness to mosquitoes; CESC cis rs1788820 0.917 rs1624695 chr18:21142992 A/T cg14672496 chr18:21087552 C18orf8 0.54 7.35 0.41 2.42e-12 Body mass index; CESC cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.07e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.78 0.59 4.93e-26 Alzheimer's disease; CESC cis rs3793683 0.597 rs12767469 chr10:134587261 C/G cg27297192 chr10:134578999 INPP5A 0.4 5.2 0.3 4.03e-7 Migraine; CESC cis rs17376456 0.825 rs10052662 chr5:93271385 A/G cg21475434 chr5:93447410 FAM172A 0.76 6.33 0.36 1.04e-9 Diabetic retinopathy; CESC cis rs9457247 1.000 rs436707 chr6:167388843 T/C cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg20607287 chr7:12443886 VWDE -0.79 -9.27 -0.49 6.78e-18 Coronary artery disease; CESC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg18512352 chr11:47633146 NA -0.56 -7.98 -0.44 4.37e-14 Subjective well-being; CESC cis rs76878669 0.561 rs10791876 chr11:66169646 C/T cg18002602 chr11:66138449 SLC29A2 -0.43 -7.09 -0.4 1.22e-11 Educational attainment (years of education); CESC cis rs2228479 0.867 rs34604714 chr16:89948985 A/G cg06558623 chr16:89946397 TCF25 1.06 8.98 0.48 5.17e-17 Skin colour saturation; CESC cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -8.97 -0.48 5.55e-17 Personality dimensions; CESC cis rs3126085 0.935 rs1552993 chr1:152171483 A/G cg03465714 chr1:152285911 FLG -0.43 -5.28 -0.31 2.72e-7 Atopic dermatitis; CESC trans rs10435719 0.902 rs7006538 chr8:11804982 A/G cg15556689 chr8:8085844 FLJ10661 0.52 6.57 0.37 2.66e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08187779 chr8:102217898 ZNF706 0.45 6.02 0.35 5.92e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08606227 chr7:128095950 C7orf68 0.6 7.01 0.4 1.94e-11 Gut microbiome composition (summer); CESC cis rs10870270 0.912 rs7079991 chr10:133736130 A/G cg17892150 chr10:133769511 PPP2R2D -0.86 -12.69 -0.61 3.83e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs3806843 0.900 rs2563280 chr5:140131530 G/C cg26395211 chr5:140044315 WDR55 0.39 5.09 0.3 6.79e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2952156 0.684 rs881844 chr17:37810218 C/G cg07936489 chr17:37558343 FBXL20 -0.63 -8.24 -0.45 8.25e-15 Asthma; CESC cis rs17293817 0.589 rs2387655 chr10:1420493 A/G cg04271617 chr10:1416546 ADARB2 0.36 5.73 0.33 2.68e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg01475377 chr6:109611718 NA -0.51 -8.5 -0.46 1.44e-15 Reticulocyte fraction of red cells; CESC cis rs2262909 0.962 rs73019842 chr19:22249909 T/G cg11619707 chr19:22235551 ZNF257 0.33 5.17 0.3 4.65e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg05132306 chr1:1846340 CALML6 -0.31 -6.57 -0.37 2.6e-10 Body mass index; CESC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg07701084 chr6:150067640 NUP43 -0.47 -6.54 -0.37 3.18e-10 Lung cancer; CESC cis rs5753618 0.561 rs737887 chr22:31696615 A/G cg13145458 chr22:31556086 RNF185 0.51 5.78 0.33 2.14e-8 Colorectal cancer; CESC cis rs7707921 0.541 rs10066167 chr5:81495445 C/T cg15871215 chr5:81402204 ATG10 0.47 6.81 0.39 6.36e-11 Breast cancer; CESC cis rs4819052 0.679 rs2255761 chr21:46683622 A/G cg11663144 chr21:46675770 NA -0.43 -6.61 -0.38 2.09e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2562152 0.744 rs1045001 chr16:107275 G/T cg02949481 chr16:131562 MPG -0.54 -6.43 -0.37 5.76e-10 Glioblastoma; CESC cis rs6570726 0.935 rs401888 chr6:145831535 A/G cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs1814175 0.715 rs11040586 chr11:49858432 T/A cg03929089 chr4:120376271 NA -0.91 -15.11 -0.68 1.3e-37 Height; CESC cis rs13191362 1.000 rs35424047 chr6:163029715 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 5.53 0.32 7.85e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2439831 0.850 rs7169988 chr15:44060435 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.93 0.44 6.03e-14 Lung cancer in ever smokers; CESC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 19.06 0.76 1.35e-51 Prudent dietary pattern; CESC cis rs12474201 0.862 rs13025595 chr2:46977893 A/G cg06386533 chr2:46925753 SOCS5 0.84 11.56 0.58 2.69e-25 Height; CESC cis rs1707322 1.000 rs6677777 chr1:46475836 A/G cg05343316 chr1:45956843 TESK2 0.45 5.22 0.31 3.7e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7429990 0.965 rs11707679 chr3:47956506 T/C cg11946769 chr3:48343235 NME6 0.46 5.59 0.32 5.54e-8 Educational attainment (years of education); CESC cis rs155076 1.000 rs261404 chr13:21858162 T/G cg11317459 chr13:21872234 NA -0.97 -11.01 -0.56 1.78e-23 White matter hyperintensity burden; CESC cis rs2816062 0.813 rs2816040 chr1:18889536 C/T cg18795169 chr1:18902165 NA 0.9 17.43 0.73 7.63e-46 Urate levels in lean individuals; CESC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg23758822 chr17:41437982 NA 1.04 16.13 0.7 2.93e-41 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17189435 chr8:141467699 TRAPPC9 0.53 6.31 0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs11098499 0.863 rs2170276 chr4:120485824 A/C cg09307838 chr4:120376055 NA 0.9 12.45 0.61 2.6e-28 Corneal astigmatism; CESC cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg05776053 chr2:74358815 NA 0.41 5.15 0.3 5.01e-7 Gestational age at birth (maternal effect); CESC cis rs798766 1.000 rs11732213 chr4:1704244 T/C cg05874882 chr4:1763078 NA 0.55 6.7 0.38 1.28e-10 Bladder cancer;Urinary bladder cancer; CESC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg19592336 chr6:28129416 ZNF389 0.46 6.19 0.36 2.28e-9 Parkinson's disease; CESC cis rs589448 0.933 rs523398 chr12:69752775 C/T cg14784868 chr12:69753453 YEATS4 0.91 14.57 0.67 1.05e-35 Cerebrospinal fluid biomarker levels; CESC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs9291683 0.655 rs3822242 chr4:10094904 T/C cg00071950 chr4:10020882 SLC2A9 -0.59 -9.56 -0.51 8.41e-19 Bone mineral density; CESC cis rs9549260 0.591 rs9577115 chr13:41276553 T/C cg21288729 chr13:41239152 FOXO1 0.57 7.59 0.42 5.49e-13 Red blood cell count; CESC trans rs61931739 0.500 rs7303318 chr12:34467789 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.51 0.42 9.28e-13 Morning vs. evening chronotype; CESC trans rs9325144 0.555 rs1973292 chr12:38679626 T/C cg23762105 chr12:34175262 ALG10 -0.48 -6.5 -0.37 3.86e-10 Morning vs. evening chronotype; CESC cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg15556689 chr8:8085844 FLJ10661 0.43 5.34 0.31 2e-7 Mood instability; CESC cis rs11122272 0.735 rs2808604 chr1:231538916 T/C cg06096015 chr1:231504339 EGLN1 0.42 6.05 0.35 4.97e-9 Hemoglobin concentration; CESC cis rs9902453 0.704 rs2628179 chr17:28071796 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -8.48 -0.46 1.64e-15 Coffee consumption (cups per day); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17553389 chr17:66243667 AMZ2 -0.51 -6.48 -0.37 4.44e-10 Ulcerative colitis; CESC trans rs3780486 0.846 rs7849148 chr9:33138352 A/T cg20290983 chr6:43655470 MRPS18A 0.98 17.7 0.74 8.37e-47 IgG glycosylation; CESC cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg20891283 chr12:69753455 YEATS4 0.91 15.03 0.68 2.41e-37 Blood protein levels; CESC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18865796 chr19:11457210 TMEM205;CCDC159 0.52 6.05 0.35 4.87e-9 Gut microbiome composition (summer); CESC cis rs7084402 0.934 rs1658455 chr10:60306089 G/C cg07615347 chr10:60278583 BICC1 0.59 9.34 0.5 4.23e-18 Refractive error; CESC cis rs9527 0.590 rs7897663 chr10:104905604 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg26597838 chr10:835615 NA 0.86 8.88 0.48 1.05e-16 Eosinophil percentage of granulocytes; CESC cis rs4843747 0.671 rs74729706 chr16:88104159 C/T cg06374794 chr16:88002281 BANP 0.39 5.08 0.3 7.04e-7 Menopause (age at onset); CESC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs847577 0.748 rs940431 chr7:97716495 C/T cg24562669 chr7:97807699 LMTK2 0.63 10.15 0.53 1.13e-20 Breast cancer; CESC cis rs6681460 0.934 rs4655635 chr1:67068240 T/G cg02459107 chr1:67143332 SGIP1 0.35 5.13 0.3 5.51e-7 Presence of antiphospholipid antibodies; CESC cis rs2997447 0.633 rs6665062 chr1:26362001 C/T cg19633962 chr1:26362018 EXTL1 -0.62 -5.88 -0.34 1.25e-8 QRS complex (12-leadsum); CESC trans rs57221529 0.654 rs12515813 chr5:671826 A/T cg25482853 chr8:67687455 SGK3 0.97 9.47 0.5 1.67e-18 Lung disease severity in cystic fibrosis; CESC cis rs10791323 0.598 rs10750550 chr11:133736083 A/G cg15485101 chr11:133734466 NA 0.33 5.73 0.33 2.73e-8 Childhood ear infection; CESC cis rs2243480 1.000 rs7804223 chr7:65664559 T/G cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.25e-32 Diabetic kidney disease; CESC cis rs2289583 0.503 rs12050494 chr15:75260896 G/A cg14664628 chr15:75095509 CSK 0.52 6.07 0.35 4.51e-9 Systemic lupus erythematosus; CESC cis rs10242455 0.867 rs2687141 chr7:99321479 T/C cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 11.0 0.56 1.98e-23 Platelet count; CESC cis rs7267979 0.966 rs2482948 chr20:25296499 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.08 -0.7 4.65e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs10751667 0.643 rs10751669 chr11:942344 C/G cg06064525 chr11:970664 AP2A2 0.52 10.32 0.54 3.35e-21 Alzheimer's disease (late onset); CESC cis rs4664308 0.875 rs7593593 chr2:160933811 C/T cg03641300 chr2:160917029 PLA2R1 -0.67 -9.84 -0.52 1.11e-19 Idiopathic membranous nephropathy; CESC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.5 -0.37 4e-10 Electroencephalogram traits; CESC cis rs9329289 0.550 rs11251294 chr10:2562328 C/T cg15501526 chr10:2543763 NA -0.39 -5.92 -0.34 1.01e-8 Age-related hearing impairment; CESC cis rs11997175 0.603 rs7464053 chr8:33786938 C/A ch.8.33884649F chr8:33765107 NA 0.48 5.79 0.33 2.01e-8 Body mass index; CESC cis rs7212590 0.618 rs7219051 chr17:58032710 G/A cg20303301 chr17:57937339 TUBD1 -0.55 -5.57 -0.32 6.25e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs727505 0.721 rs56269941 chr7:124768732 T/A cg23710748 chr7:124431027 NA -0.37 -6.18 -0.35 2.43e-9 Lewy body disease; CESC cis rs66573146 1.000 rs9942188 chr4:6984181 C/T cg00086871 chr4:6988644 TBC1D14 1.12 6.94 0.39 2.96e-11 Granulocyte percentage of myeloid white cells; CESC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg03806693 chr22:41940476 POLR3H -1.25 -17.05 -0.72 1.64e-44 Vitiligo; CESC cis rs4315565 0.688 rs6546477 chr2:69281345 G/T cg12800200 chr2:69260302 ANTXR1 -0.39 -5.59 -0.32 5.64e-8 Height; CESC cis rs1008375 1.000 rs114490726 chr4:17680898 T/C cg02297831 chr4:17616191 MED28 0.45 5.76 0.33 2.29e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7814319 0.933 rs7827095 chr8:97239126 C/T cg20787634 chr8:97240163 UQCRB 0.54 7.12 0.4 1.04e-11 Lung function (FVC); CESC cis rs34779708 0.733 rs60553075 chr10:35542462 T/A cg03585969 chr10:35415529 CREM 0.56 6.42 0.37 6.15e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs7582720 1.000 rs72936882 chr2:203794439 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs72634258 0.836 rs9658012 chr1:7989022 C/T cg00042356 chr1:8021962 PARK7 0.86 7.94 0.44 5.73e-14 Inflammatory bowel disease; CESC cis rs933688 1.000 rs9293568 chr5:90737845 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 11.09 0.56 1.03e-23 Smoking behavior; CESC cis rs72781680 0.898 rs72780121 chr2:23995918 T/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg07701084 chr6:150067640 NUP43 0.44 6.27 0.36 1.47e-9 Lung cancer; CESC cis rs10927875 0.541 rs1763596 chr1:16343835 C/T cg22431228 chr1:16359049 CLCNKA -0.52 -9.9 -0.52 7.22e-20 Dilated cardiomyopathy; CESC cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg26874164 chr19:58962979 ZNF324B 0.59 8.0 0.44 3.88e-14 Uric acid clearance; CESC cis rs6736093 0.933 rs6754526 chr2:112729669 A/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.57 -0.32 6.33e-8 Coronary artery disease; CESC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.48 0.42 1.1e-12 Tonsillectomy; CESC cis rs7809950 1.000 rs2520269 chr7:107191327 T/C cg23024343 chr7:107201750 COG5 -0.45 -6.07 -0.35 4.38e-9 Coronary artery disease; CESC cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg05347473 chr6:146136440 FBXO30 -0.57 -7.26 -0.41 4.42e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs889398 0.771 rs4985448 chr16:69899395 A/G cg09409435 chr16:70099608 PDXDC2 0.4 5.07 0.3 7.64e-7 Body mass index; CESC cis rs3092073 0.624 rs13040315 chr20:44585793 A/G cg17986701 chr20:44574422 PCIF1 0.33 5.13 0.3 5.51e-7 Intelligence (multi-trait analysis); CESC cis rs6456156 0.792 rs4710181 chr6:167513998 T/C cg07741184 chr6:167504864 NA 0.38 6.92 0.39 3.46e-11 Primary biliary cholangitis; CESC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg17372223 chr3:52568218 NT5DC2 0.4 5.58 0.32 6.05e-8 Bipolar disorder; CESC cis rs6138458 1.000 rs6114981 chr20:24974401 C/T cg06937882 chr20:24974362 C20orf3 0.33 5.15 0.3 4.99e-7 Blood protein levels; CESC cis rs2617583 0.967 rs2550948 chr5:1450444 C/T cg07151155 chr5:1473589 LPCAT1 -0.34 -5.24 -0.31 3.34e-7 Breast cancer; CESC cis rs11098499 0.954 rs10008459 chr4:120394231 T/C cg09307838 chr4:120376055 NA 0.94 13.97 0.65 1.31e-33 Corneal astigmatism; CESC cis rs2011503 0.941 rs2074302 chr19:19381728 G/C cg11584989 chr19:19387371 SF4 0.6 7.21 0.4 5.96e-12 Bipolar disorder; CESC cis rs12900413 0.687 rs34284515 chr15:90308061 T/G cg24249390 chr15:90295951 MESP1 -0.39 -5.47 -0.32 1.03e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs56104184 0.775 rs73061689 chr19:49397214 C/T cg15549821 chr19:49342101 PLEKHA4 -0.58 -5.8 -0.34 1.9e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg19163074 chr7:65112434 INTS4L2 -0.42 -5.26 -0.31 2.93e-7 Aortic root size; CESC cis rs9837602 0.935 rs9810235 chr3:99736538 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.51 0.42 9.05e-13 Breast cancer; CESC cis rs6963495 0.818 rs6944787 chr7:105147309 C/T cg13798780 chr7:105162888 PUS7 0.76 7.8 0.43 1.47e-13 Bipolar disorder (body mass index interaction); CESC trans rs61931739 0.929 rs2389272 chr12:34067771 T/C cg26384229 chr12:38710491 ALG10B -0.46 -6.6 -0.38 2.21e-10 Morning vs. evening chronotype; CESC cis rs12410462 0.892 rs35341041 chr1:227653885 G/A cg04117972 chr1:227635322 NA 0.62 6.0 0.35 6.56e-9 Major depressive disorder; CESC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg05564831 chr3:52568323 NT5DC2 0.48 7.76 0.43 1.88e-13 Electroencephalogram traits; CESC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg05863683 chr7:1912471 MAD1L1 -0.39 -5.68 -0.33 3.49e-8 Bipolar disorder and schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11768411 chr8:144329279 ZFP41 -0.45 -6.12 -0.35 3.27e-9 Fibrinogen levels; CESC cis rs13082711 0.911 rs73046191 chr3:27454398 T/A cg02860705 chr3:27208620 NA 0.54 7.0 0.39 2.13e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs8014204 0.836 rs7154256 chr14:75252587 A/G cg08847533 chr14:75593920 NEK9 0.46 5.84 0.34 1.53e-8 Caffeine consumption; CESC cis rs9560113 0.508 rs2774425 chr13:112235077 A/G cg10483660 chr13:112241077 NA -0.43 -7.39 -0.41 1.96e-12 Menarche (age at onset); CESC cis rs727505 0.607 rs17387389 chr7:124784751 T/C cg23710748 chr7:124431027 NA -0.4 -6.24 -0.36 1.73e-9 Lewy body disease; CESC cis rs7937682 0.889 rs484013 chr11:111495779 G/A cg22437258 chr11:111473054 SIK2 0.72 9.69 0.51 3.38e-19 Primary sclerosing cholangitis; CESC cis rs791888 0.858 rs2180968 chr10:89418730 A/C cg13926569 chr10:89418898 PAPSS2 0.49 6.83 0.39 5.67e-11 Magnesium levels; CESC cis rs10751667 0.643 rs7394524 chr11:933865 T/C cg06064525 chr11:970664 AP2A2 -0.52 -10.37 -0.54 2.34e-21 Alzheimer's disease (late onset); CESC trans rs12986445 0.744 rs10209951 chr2:26144986 C/G ch.17.1742593R chr17:65528935 PITPNC1 0.51 6.05 0.35 4.87e-9 Multiple myeloma and monoclonal gammopathy;Multiple myeloma; CESC cis rs7666738 0.819 rs13139560 chr4:99081188 C/T cg05340658 chr4:99064831 C4orf37 0.61 7.1 0.4 1.17e-11 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22627950 chr7:44622302 TMED4 -0.42 -6.06 -0.35 4.6e-9 Gambling; CESC cis rs7520050 0.966 rs7515491 chr1:46355079 A/G cg24296786 chr1:45957014 TESK2 0.42 5.41 0.32 1.43e-7 Red blood cell count;Reticulocyte count; CESC cis rs10744422 0.528 rs6489245 chr12:123360151 G/A cg25930673 chr12:123319894 HIP1R -0.74 -5.67 -0.33 3.7e-8 Schizophrenia; CESC cis rs8141529 0.702 rs469990 chr22:29304200 A/T cg02153584 chr22:29168773 CCDC117 0.56 7.39 0.41 1.94e-12 Lymphocyte counts; CESC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.59 0.47 7.39e-16 Menopause (age at onset); CESC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg19592336 chr6:28129416 ZNF389 -0.5 -6.87 -0.39 4.44e-11 Depression; CESC cis rs9457247 1.000 rs2013815 chr6:167373812 T/A cg23791538 chr6:167370224 RNASET2 0.6 8.49 0.46 1.54e-15 Crohn's disease; CESC cis rs6785206 0.803 rs2712380 chr3:128338661 A/C cg16766828 chr3:128327626 NA -0.63 -6.49 -0.37 4.31e-10 Lymphocyte percentage of white cells; CESC cis rs1580019 0.922 rs766658 chr7:32499391 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.1 0.53 1.62e-20 Cognitive ability; CESC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.4 0.31 1.51e-7 Menopause (age at onset); CESC cis rs6967414 0.685 rs6944332 chr7:6758018 G/A cg00387323 chr7:6746715 ZNF12 0.61 5.77 0.33 2.21e-8 Hematocrit;Hemoglobin concentration; CESC cis rs9905704 0.574 rs35952494 chr17:57074467 C/T cg12560992 chr17:57184187 TRIM37 0.67 5.91 0.34 1.07e-8 Testicular germ cell tumor; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09666561 chr16:30406910 ZNF48 -0.47 -6.4 -0.37 7.2e-10 Fibrinogen levels; CESC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg06494592 chr3:125709126 NA -0.49 -5.2 -0.3 3.92e-7 Blood pressure (smoking interaction); CESC cis rs9309473 0.848 rs17009159 chr2:73797762 A/T cg20560298 chr2:73613845 ALMS1 -0.54 -7.11 -0.4 1.1e-11 Metabolite levels; CESC cis rs863345 0.967 rs11265029 chr1:158529281 C/T cg12129480 chr1:158549410 OR10X1 -0.32 -6.52 -0.37 3.64e-10 Pneumococcal bacteremia; CESC cis rs6076065 0.707 rs2024746 chr20:23356862 G/A cg11657817 chr20:23433608 CST11 0.41 6.29 0.36 1.29e-9 Facial morphology (factor 15, philtrum width); CESC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg05368731 chr17:41323189 NBR1 0.79 11.13 0.56 7.24e-24 Menopause (age at onset); CESC trans rs61931739 0.500 rs11053223 chr12:34481947 T/A cg13010199 chr12:38710504 ALG10B 0.5 6.5 0.37 3.92e-10 Morning vs. evening chronotype; CESC cis rs7917772 0.582 rs7906115 chr10:104327164 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.61 0.33 5.05e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2637266 1.000 rs1077916 chr10:78381951 G/A cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs9527 0.590 rs11191544 chr10:104827198 C/G cg04362960 chr10:104952993 NT5C2 0.44 5.76 0.33 2.38e-8 Arsenic metabolism; CESC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg00684032 chr4:1343700 KIAA1530 0.56 8.59 0.47 7.56e-16 Obesity-related traits; CESC cis rs8078723 1.000 rs8078723 chr17:38166879 A/G cg17467752 chr17:38218738 THRA 0.7 10.64 0.55 3.04e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs2239547 0.618 rs3733047 chr3:52871929 A/G cg11645453 chr3:52864694 ITIH4 -0.37 -6.51 -0.37 3.75e-10 Schizophrenia; CESC cis rs9905704 0.918 rs72828707 chr17:56883236 A/G cg12560992 chr17:57184187 TRIM37 0.61 7.16 0.4 7.98e-12 Testicular germ cell tumor; CESC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg06074448 chr4:187884817 NA -0.37 -5.43 -0.32 1.27e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.7 6.63 0.38 1.85e-10 Initial pursuit acceleration; CESC cis rs6121246 0.697 rs6088864 chr20:30228157 G/A cg13852791 chr20:30311386 BCL2L1 0.77 7.79 0.43 1.48e-13 Mean corpuscular hemoglobin; CESC cis rs7727544 0.684 rs272869 chr5:131677997 A/G cg07395648 chr5:131743802 NA -0.39 -5.17 -0.3 4.58e-7 Blood metabolite levels; CESC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.66 9.22 0.49 9.27e-18 Menopause (age at onset); CESC cis rs1577917 0.917 rs35038582 chr6:86721305 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.03 -0.35 5.34e-9 Response to antipsychotic treatment; CESC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.7 -7.95 -0.44 5.54e-14 Gut microbiome composition (summer); CESC trans rs9951602 0.512 rs9304070 chr18:76654890 A/C cg02800362 chr5:177631904 HNRNPAB 0.66 9.41 0.5 2.41e-18 Obesity-related traits; CESC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.49 6.46 0.37 5.09e-10 Lymphocyte counts; CESC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg25985355 chr7:65971099 NA 0.32 5.23 0.31 3.43e-7 Aortic root size; CESC cis rs4974559 0.739 rs6599298 chr4:1298122 A/G cg02980000 chr4:1222292 CTBP1 0.78 7.13 0.4 9.41e-12 Systolic blood pressure; CESC cis rs4835473 0.932 rs1842484 chr4:144714982 G/C cg25736465 chr4:144833511 NA 0.33 5.43 0.32 1.29e-7 Immature fraction of reticulocytes; CESC cis rs3741151 0.773 rs17310361 chr11:73233724 T/C cg17517138 chr11:73019481 ARHGEF17 0.78 6.37 0.36 8.35e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs9814567 0.858 rs4955548 chr3:134341060 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.67 -0.33 3.78e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg06397424 chr16:15737279 NDE1;KIAA0430 -0.44 -5.99 -0.35 6.64e-9 Breast cancer;Type 2 diabetes; CESC cis rs1153858 1.000 rs56850226 chr15:45633118 T/C cg14582100 chr15:45693742 SPATA5L1 0.44 6.28 0.36 1.38e-9 Homoarginine levels; CESC trans rs2727020 0.523 rs4115783 chr11:49556026 G/A cg03929089 chr4:120376271 NA 0.73 8.46 0.46 1.79e-15 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08519270 chr4:190861788 FRG1 0.67 7.63 0.42 4.19e-13 Gut microbiome composition (summer); CESC cis rs854765 0.547 rs2955372 chr17:17970229 T/C cg09796270 chr17:17721594 SREBF1 -0.38 -5.07 -0.3 7.49e-7 Total body bone mineral density; CESC cis rs9911578 1.000 rs7216680 chr17:56988243 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.41 5.4 0.31 1.48e-7 Intelligence (multi-trait analysis); CESC trans rs4927850 1.000 rs10881563 chr3:195750225 A/G cg21051086 chr3:73046214 PPP4R2 -0.45 -6.27 -0.36 1.45e-9 Pancreatic cancer; CESC cis rs67311347 0.577 rs1880763 chr3:40283255 C/T cg09455208 chr3:40491958 NA -0.35 -5.59 -0.33 5.5e-8 Renal cell carcinoma; CESC cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg13104385 chr7:22767384 IL6 0.45 6.12 0.35 3.38e-9 Lung cancer; CESC cis rs7917772 0.503 rs11191320 chr10:104293394 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.24 0.41 4.83e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg02079420 chr8:82753780 SNX16 0.53 8.0 0.44 3.95e-14 Diastolic blood pressure; CESC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.59 0.64 2.8e-32 Prudent dietary pattern; CESC cis rs4889855 0.556 rs11651818 chr17:78530300 A/G cg16591659 chr17:78472290 NA 0.38 6.31 0.36 1.14e-9 Fractional excretion of uric acid; CESC cis rs10832963 0.847 rs4237722 chr11:18639363 T/C cg20219074 chr11:18656078 SPTY2D1 0.77 10.66 0.55 2.51e-22 Breast cancer; CESC cis rs7474896 0.515 rs594594 chr10:38307723 A/G cg25427524 chr10:38739819 LOC399744 0.49 5.48 0.32 1.01e-7 Obesity (extreme); CESC cis rs10242455 0.702 rs73403290 chr7:99157828 C/T cg25640893 chr7:99214727 ZNF498 0.71 5.21 0.3 3.87e-7 Blood metabolite levels; CESC cis rs9325144 0.671 rs12818797 chr12:39019409 A/G cg26384229 chr12:38710491 ALG10B -0.52 -7.27 -0.41 4e-12 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg05340658 chr4:99064831 C4orf37 0.78 11.87 0.59 2.5e-26 Colonoscopy-negative controls vs population controls; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg00852768 chr6:163834924 QKI 0.44 6.07 0.35 4.4e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs79911532 0.515 rs10245109 chr7:75846115 G/T cg06959773 chr7:76033795 SRCRB4D;ZP3 0.56 5.24 0.31 3.23e-7 Mononucleosis; CESC cis rs17376456 0.542 rs2084916 chr5:93194961 A/T cg21475434 chr5:93447410 FAM172A -0.52 -5.25 -0.31 3.13e-7 Diabetic retinopathy; CESC cis rs763014 0.833 rs3743903 chr16:632736 T/C cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC cis rs763121 0.853 rs5757196 chr22:39039855 G/C cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC cis rs7618915 0.679 rs6802320 chr3:52241835 T/C cg05315796 chr3:52349193 DNAH1 0.37 6.34 0.36 9.71e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02801482 chr2:159824941 TANC1 0.56 6.3 0.36 1.21e-9 Gut microbiome composition (summer); CESC cis rs7660520 0.524 rs4862100 chr4:183732709 G/T cg04181038 chr4:183730758 NA 0.63 6.9 0.39 3.91e-11 Pediatric autoimmune diseases; CESC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg12373951 chr3:133503437 NA 0.5 7.43 0.42 1.53e-12 Iron status biomarkers; CESC cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg16262614 chr3:133464971 TF 0.43 8.64 0.47 5.58e-16 Iron status biomarkers (transferrin levels); CESC cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg03060546 chr3:49711283 APEH -0.51 -6.82 -0.39 6.32e-11 Menarche (age at onset); CESC cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.74 10.73 0.55 1.58e-22 Eosinophil percentage of white cells; CESC cis rs734999 0.588 rs2260976 chr1:2527678 A/G cg20673091 chr1:2541236 MMEL1 -0.44 -7.23 -0.41 5.08e-12 Ulcerative colitis; CESC cis rs11098499 0.863 rs7657849 chr4:120455494 T/C cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.24e-28 Corneal astigmatism; CESC cis rs4635969 0.718 rs27071 chr5:1346081 T/C cg07493874 chr5:1342172 CLPTM1L -0.43 -6.19 -0.36 2.3e-9 Testicular germ cell tumor;Testicular germ cell cancer; CESC cis rs7481584 0.669 rs12421922 chr11:3035070 A/G cg25174290 chr11:3078921 CARS -0.44 -5.87 -0.34 1.31e-8 Calcium levels; CESC cis rs2279817 0.735 rs12075624 chr1:17991573 A/G cg21791023 chr1:18019539 ARHGEF10L -0.6 -7.65 -0.43 3.74e-13 Neuroticism; CESC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg00149659 chr3:10157352 C3orf10 0.73 8.58 0.47 7.94e-16 Alzheimer's disease; CESC cis rs6088580 0.634 rs6141471 chr20:33006730 A/G cg24642439 chr20:33292090 TP53INP2 -0.53 -6.98 -0.39 2.39e-11 Glomerular filtration rate (creatinine); CESC cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg23649088 chr2:200775458 C2orf69 -0.53 -5.2 -0.3 4.06e-7 Schizophrenia; CESC cis rs1801251 0.752 rs2592126 chr2:233751377 A/G cg08000102 chr2:233561755 GIGYF2 -0.58 -7.81 -0.43 1.38e-13 Coronary artery disease; CESC cis rs8180040 1.000 rs8180040 chr3:47388947 A/T cg27129171 chr3:47204927 SETD2 0.65 9.9 0.52 7.51e-20 Colorectal cancer; CESC cis rs10752881 0.602 rs9425569 chr1:182942202 C/T ch.1.3577855R chr1:183094577 LAMC1 0.56 7.08 0.4 1.27e-11 Colorectal cancer; CESC cis rs938554 0.513 rs3775947 chr4:9995240 C/T cg00071950 chr4:10020882 SLC2A9 0.67 8.59 0.47 7.72e-16 Blood metabolite levels; CESC trans rs11098499 0.863 rs59732491 chr4:120489588 G/C cg25214090 chr10:38739885 LOC399744 0.65 8.73 0.47 2.86e-16 Corneal astigmatism; CESC cis rs9747201 0.963 rs4789729 chr17:80146089 G/A cg09264619 chr17:80180166 NA -0.43 -5.08 -0.3 7.24e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg23281280 chr6:28129359 ZNF389 0.46 6.39 0.37 7.42e-10 Parkinson's disease; CESC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg06808227 chr14:105710500 BRF1 -0.6 -6.74 -0.38 9.78e-11 Mean platelet volume;Platelet distribution width; CESC cis rs1215050 0.791 rs1506438 chr4:98789542 C/T cg17366294 chr4:99064904 C4orf37 0.39 5.04 0.3 8.81e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7927771 1.000 rs9909 chr11:47799775 C/G cg05585544 chr11:47624801 NA -0.5 -7.81 -0.43 1.38e-13 Subjective well-being; CESC cis rs7927592 0.513 rs7950129 chr11:68202903 A/G cg16797656 chr11:68205561 LRP5 0.63 9.97 0.52 4.43e-20 Total body bone mineral density; CESC cis rs4253772 0.515 rs8142080 chr22:46647429 G/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.62 5.29 0.31 2.55e-7 LDL cholesterol;Cholesterol, total; CESC cis rs1348850 0.914 rs12616443 chr2:178315751 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.72 9.95 0.52 5.01e-20 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg12463550 chr7:65579703 CRCP 0.49 6.11 0.35 3.61e-9 Aortic root size; CESC cis rs9303401 0.734 rs8073316 chr17:57211381 A/T cg10487724 chr17:56770010 TEX14;RAD51C -0.65 -8.05 -0.44 2.89e-14 Cognitive test performance; CESC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.42 0.37 6.1e-10 Bipolar disorder; CESC cis rs9612 0.718 rs346535 chr19:44251425 C/T cg08581076 chr19:44259116 C19orf61 0.43 5.24 0.31 3.2e-7 Exhaled nitric oxide output; CESC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg11859384 chr17:80120422 CCDC57 0.4 5.5 0.32 8.88e-8 Life satisfaction; CESC cis rs2932538 0.922 rs6691917 chr1:113137043 G/C cg22162597 chr1:113214053 CAPZA1 0.48 6.42 0.37 6.28e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs1003719 0.591 rs1053984 chr21:38574018 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.74 -0.43 2.09e-13 Eye color traits; CESC cis rs17376456 0.825 rs55724660 chr5:93276636 A/G cg25358565 chr5:93447407 FAM172A 1.13 10.24 0.53 6.15e-21 Diabetic retinopathy; CESC cis rs2072499 0.865 rs2758603 chr1:156198994 T/C cg25208724 chr1:156163844 SLC25A44 0.83 13.17 0.63 8.26e-31 Testicular germ cell tumor; CESC cis rs7772486 0.764 rs9399569 chr6:146242942 C/T cg23711669 chr6:146136114 FBXO30 -0.82 -11.64 -0.58 1.47e-25 Lobe attachment (rater-scored or self-reported); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg11303561 chr19:1206399 STK11 0.46 6.0 0.35 6.33e-9 Bronchopulmonary dysplasia; CESC cis rs727505 0.583 rs17147421 chr7:124383948 C/T cg23710748 chr7:124431027 NA -0.39 -5.79 -0.34 1.98e-8 Lewy body disease; CESC cis rs7264396 0.790 rs6121015 chr20:34243017 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.7 0.43 2.63e-13 Total cholesterol levels; CESC cis rs12048904 0.930 rs11166529 chr1:101333733 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.58 7.65 0.43 3.71e-13 Multiple sclerosis; CESC cis rs16854884 0.582 rs35211123 chr3:143640171 A/T cg01302019 chr3:143689584 C3orf58 -0.34 -5.16 -0.3 4.89e-7 Economic and political preferences (feminism/equality); CESC cis rs1133146 1.000 rs1133146 chr19:53666660 A/G cg09412792 chr19:54664028 TMC4;LENG1 0.4 5.17 0.3 4.63e-7 Yu-Zhi constitution type in type 2 diabetes; CESC cis rs9486715 1.000 rs6905737 chr6:97066659 A/T cg06623918 chr6:96969491 KIAA0776 -0.86 -12.44 -0.61 2.82e-28 Headache; CESC cis rs9359856 0.564 rs61739327 chr6:90340446 C/T cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.6 -0.33 5.29e-8 Bipolar disorder; CESC cis rs10979 0.597 rs9399449 chr6:143908376 C/T cg25407410 chr6:143891975 LOC285740 -0.49 -6.35 -0.36 9.21e-10 Hypospadias; CESC cis rs9916302 0.904 rs1619021 chr17:37739274 G/A cg07936489 chr17:37558343 FBXL20 -0.78 -10.54 -0.54 6.5600000000000005e-22 Glomerular filtration rate (creatinine); CESC trans rs829883 1.000 rs829883 chr12:98879606 G/A cg04550079 chr16:67212681 KIAA0895L -0.37 -6.07 -0.35 4.34e-9 Colorectal adenoma (advanced); CESC cis rs7561273 0.586 rs11892283 chr2:24317850 T/C cg01493198 chr2:24299560 SF3B14 0.42 5.13 0.3 5.69e-7 Quantitative traits; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg23142935 chr16:22385308 CDR2 -0.55 -6.23 -0.36 1.83e-9 Lung cancer in ever smokers; CESC cis rs10751667 0.666 rs6597962 chr11:976351 C/T cg20946044 chr11:1010712 AP2A2 -0.4 -5.46 -0.32 1.11e-7 Alzheimer's disease (late onset); CESC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg23978390 chr7:1156363 C7orf50 0.56 7.44 0.42 1.44e-12 Longevity;Endometriosis; CESC cis rs12971120 0.504 rs11665154 chr18:72147006 A/C cg26446133 chr18:72167187 CNDP2 -0.55 -7.94 -0.44 5.67e-14 Refractive error; CESC cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg18180107 chr4:99064573 C4orf37 0.39 5.13 0.3 5.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6541297 1.000 rs6541297 chr1:230283506 G/A cg20703242 chr1:230279135 GALNT2 0.65 10.46 0.54 1.13e-21 Coronary artery disease; CESC cis rs1957429 0.901 rs1951490 chr14:65346957 G/T cg23373153 chr14:65346875 NA 0.96 11.51 0.58 4.06e-25 Pediatric areal bone mineral density (radius); CESC cis rs9388451 0.839 rs4897157 chr6:126102981 A/T cg10911889 chr6:126070802 HEY2 0.37 5.15 0.3 5.13e-7 Brugada syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04667467 chr16:90089176 GAS8 0.56 6.54 0.37 3.14e-10 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02328807 chr16:75269564 BCAR1 0.42 6.05 0.35 5.01e-9 Asthma; CESC cis rs4969178 0.932 rs3744219 chr17:76400236 G/A cg20026190 chr17:76395443 PGS1 0.46 7.35 0.41 2.41e-12 HDL cholesterol levels; CESC cis rs3796352 1.000 rs116616340 chr3:53132371 C/G cg12962167 chr3:53033115 SFMBT1 0.54 5.13 0.3 5.5e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs597539 0.690 rs615644 chr11:68621806 G/C cg21963583 chr11:68658836 MRPL21 0.4 5.39 0.31 1.52e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9443645 0.527 rs10943600 chr6:79611505 G/A cg05283184 chr6:79620031 NA -0.36 -5.16 -0.3 4.91e-7 Intelligence (multi-trait analysis); CESC cis rs2573652 1.000 rs2581359 chr15:100513707 A/G cg09918751 chr15:100517450 ADAMTS17 -0.39 -7.49 -0.42 1.04e-12 Height; CESC cis rs4700695 0.668 rs153393 chr5:65428707 A/G cg21114390 chr5:65439923 SFRS12 -0.49 -5.84 -0.34 1.49e-8 Facial morphology (factor 19); CESC trans rs7937682 0.889 rs3017767 chr11:111508098 A/G cg18187862 chr3:45730750 SACM1L 0.51 6.47 0.37 4.81e-10 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09592456 chr22:19780308 GNB1L -0.59 -7.11 -0.4 1.09e-11 Gut microbiome composition (summer); CESC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg06108461 chr20:60628389 TAF4 -0.92 -14.32 -0.66 7.92e-35 Body mass index; CESC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg20790798 chr5:1857306 NA -0.38 -5.11 -0.3 6.21e-7 Cardiovascular disease risk factors; CESC cis rs2456568 0.709 rs1354765 chr11:93637776 G/T cg26875233 chr11:93583750 C11orf90 0.3 5.26 0.31 2.91e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs2668423 0.502 rs2074898 chr19:1391361 A/G cg02639931 chr19:1387894 NDUFS7 -0.7 -14.28 -0.66 1.06e-34 Nonalcoholic fatty liver disease; CESC cis rs7772486 0.846 rs6908063 chr6:146403618 T/C cg23711669 chr6:146136114 FBXO30 0.78 11.61 0.58 1.77e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs7267979 0.899 rs442834 chr20:25458096 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.78 0.67 1.87e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs9614461 0.609 rs9614653 chr22:45767391 A/G cg01808030 chr22:45809952 RIBC2;SMC1B -0.66 -7.26 -0.41 4.37e-12 Tonsillectomy; CESC cis rs1552244 0.882 rs13100734 chr3:10022878 A/G cg00149659 chr3:10157352 C3orf10 0.7 8.16 0.45 1.35e-14 Alzheimer's disease; CESC cis rs2075371 0.829 rs1993058 chr7:133930361 G/A cg00033643 chr7:134001901 SLC35B4 0.41 5.22 0.31 3.65e-7 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26464252 chr10:6186649 PFKFB3 -0.46 -6.1 -0.35 3.73e-9 Fibrinogen levels; CESC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg10792982 chr14:105748885 BRF1 -0.44 -5.75 -0.33 2.47e-8 Mean platelet volume;Platelet distribution width; CESC cis rs8072100 0.967 rs8075411 chr17:45676760 C/T cg08085267 chr17:45401833 C17orf57 0.4 5.15 0.3 5.18e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9894429 0.671 rs6565616 chr17:79612161 C/T cg21984481 chr17:79567631 NPLOC4 -0.35 -5.4 -0.31 1.49e-7 Eye color traits; CESC cis rs1728785 1.000 rs1749793 chr16:68569312 C/T cg02972257 chr16:68554789 NA -0.62 -6.93 -0.39 3.14e-11 Ulcerative colitis; CESC cis rs9911578 1.000 rs2567905 chr17:56782297 T/C cg05425664 chr17:57184151 TRIM37 -0.51 -7.19 -0.4 6.81e-12 Intelligence (multi-trait analysis); CESC cis rs8031584 0.918 rs3817498 chr15:31268781 T/C cg08109568 chr15:31115862 NA -0.63 -8.2 -0.45 1.03e-14 Huntington's disease progression; CESC cis rs1003719 0.788 rs2835599 chr21:38466937 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.62 0.47 6.08e-16 Eye color traits; CESC cis rs5753618 0.561 rs2078803 chr22:31652852 G/A cg13145458 chr22:31556086 RNF185 0.46 5.26 0.31 2.98e-7 Colorectal cancer; CESC cis rs1799949 0.864 rs60309406 chr17:41435665 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.34 0.31 2.02e-7 Menopause (age at onset); CESC cis rs9948 0.655 rs62156213 chr2:97399100 T/C cg01990225 chr2:97406019 LMAN2L -1.02 -7.77 -0.43 1.76e-13 Erectile dysfunction and prostate cancer treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14293898 chr9:37780721 EXOSC3 -0.59 -7.45 -0.42 1.34e-12 Gut microbiome composition (summer); CESC cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg27347728 chr4:17578864 LAP3 0.44 5.45 0.32 1.14e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg09610735 chr10:22609918 BMI1 -0.45 -6.01 -0.35 6.11e-9 Height; CESC cis rs10791097 0.967 rs6590512 chr11:130717916 A/G cg14779329 chr11:130786720 SNX19 -0.34 -5.55 -0.32 6.96e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs911555 0.570 rs11625397 chr14:104027557 A/G cg24130564 chr14:104152367 KLC1 0.67 11.11 0.56 8.44e-24 Intelligence (multi-trait analysis); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg15988263 chr1:44412313 IPO13 -0.46 -6.05 -0.35 4.83e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs3820928 0.904 rs2396431 chr2:227765488 G/A cg11843606 chr2:227700838 RHBDD1 -0.45 -5.93 -0.34 9.45e-9 Pulmonary function; CESC cis rs3762637 0.943 rs9822345 chr3:122245598 A/G cg24169773 chr3:122142474 KPNA1 -0.59 -6.88 -0.39 4.42e-11 LDL cholesterol levels; CESC cis rs9487051 0.714 rs6903695 chr6:109631422 C/G cg21918786 chr6:109611834 NA 0.37 5.46 0.32 1.12e-7 Reticulocyte fraction of red cells; CESC cis rs9814567 1.000 rs13322305 chr3:134310791 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.44 -0.32 1.21e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs939658 0.805 rs8035606 chr15:79420245 C/T cg17916960 chr15:79447300 NA -0.36 -5.95 -0.34 8.39e-9 Refractive error; CESC trans rs3942852 0.955 rs1910364 chr11:48113232 A/G cg15704280 chr7:45808275 SEPT13 -0.67 -7.47 -0.42 1.18e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg02951883 chr7:2050386 MAD1L1 -0.56 -7.35 -0.41 2.42e-12 Bipolar disorder and schizophrenia; CESC cis rs67478160 0.575 rs8014294 chr14:104322983 A/G cg08213375 chr14:104286397 PPP1R13B 0.38 7.18 0.4 6.85e-12 Schizophrenia; CESC cis rs2820292 0.710 rs2047264 chr1:201886402 C/T cg06775570 chr1:201857621 SHISA4 0.31 5.09 0.3 6.77e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg18876405 chr7:65276391 NA -0.45 -5.46 -0.32 1.08e-7 Aortic root size; CESC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg21782813 chr7:2030301 MAD1L1 0.4 5.75 0.33 2.5e-8 Schizophrenia; CESC cis rs4253772 0.745 rs78023664 chr22:46647844 G/A cg24881330 chr22:46731750 TRMU 0.81 5.56 0.32 6.73e-8 LDL cholesterol;Cholesterol, total; CESC cis rs59918340 0.548 rs10102728 chr8:142205964 G/A cg18755752 chr8:142205143 DENND3 -0.46 -6.06 -0.35 4.56e-9 Immature fraction of reticulocytes; CESC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg25072359 chr17:41440525 NA 0.45 5.96 0.34 7.83e-9 Menopause (age at onset); CESC cis rs9929218 0.679 rs9924886 chr16:68743939 A/C cg02972257 chr16:68554789 NA 0.58 6.55 0.37 2.97e-10 Colorectal cancer; CESC cis rs7089973 0.584 rs4752322 chr10:116613258 A/C cg25233709 chr10:116636983 FAM160B1 0.4 6.63 0.38 1.87e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.69 0.33 3.38e-8 Personality dimensions; CESC cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -6.79 -0.38 7.38e-11 Mood instability; CESC cis rs965469 0.779 rs6051710 chr20:3264661 T/C cg25506879 chr20:3388711 C20orf194 -0.47 -5.17 -0.3 4.66e-7 IFN-related cytopenia; CESC trans rs9354308 0.933 rs12203567 chr6:66589062 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 7.63 0.42 4.23e-13 Metabolite levels; CESC cis rs963731 0.649 rs1454223 chr2:39224351 G/T cg04010122 chr2:39346883 SOS1 -0.76 -5.6 -0.33 5.44e-8 Corticobasal degeneration; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg09115837 chr10:79541592 NA -0.48 -6.02 -0.35 5.81e-9 Breast cancer;Type 2 diabetes; CESC cis rs9790314 0.967 rs336586 chr3:161081347 G/A cg04691961 chr3:161091175 C3orf57 -0.41 -5.24 -0.31 3.27e-7 Morning vs. evening chronotype; CESC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg08859206 chr1:53392774 SCP2 0.6 8.84 0.48 1.36e-16 Monocyte count; CESC cis rs924840 0.634 rs2869030 chr15:78711803 A/C cg24631222 chr15:78858424 CHRNA5 0.52 6.92 0.39 3.32e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15337887 chr5:68389678 SLC30A5 0.47 6.04 0.35 5.26e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.13 0.81 3.58e-62 Prudent dietary pattern; CESC cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg00255919 chr5:131827918 IRF1 0.51 8.59 0.47 7.76e-16 Asthma (sex interaction); CESC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg18252515 chr7:66147081 NA -0.43 -5.6 -0.33 5.39e-8 Aortic root size; CESC cis rs6460942 1.000 rs62448566 chr7:12403662 G/A cg20607287 chr7:12443886 VWDE -0.68 -7.91 -0.44 6.85e-14 Coronary artery disease; CESC cis rs72945132 0.882 rs12279046 chr11:70130388 A/G cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs910316 0.737 rs175071 chr14:75498177 A/G cg15467112 chr14:75489610 MLH3 -0.33 -5.14 -0.3 5.31e-7 Height; CESC trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg06636001 chr8:8085503 FLJ10661 -0.54 -7.11 -0.4 1.1e-11 Neuroticism; CESC cis rs3796352 0.892 rs9756317 chr3:53088815 T/C cg12962167 chr3:53033115 SFMBT1 -0.59 -5.7 -0.33 3.22e-8 Immune reponse to smallpox (secreted IL-2); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20041257 chr19:10828819 DNM2;MIR638 -0.43 -6.44 -0.37 5.59e-10 Gambling; CESC cis rs863345 0.604 rs11265016 chr1:158503785 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.15e-11 Pneumococcal bacteremia; CESC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 10.0 0.52 3.4e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs35110281 0.591 rs86139 chr21:44932802 G/A cg21573476 chr21:45109991 RRP1B -0.38 -5.44 -0.32 1.19e-7 Mean corpuscular volume; CESC cis rs170557 0.573 rs12401646 chr1:210182369 A/G cg21951975 chr1:209979733 IRF6 -0.38 -5.13 -0.3 5.66e-7 Alopecia areata; CESC cis rs7264396 0.790 rs1040695 chr20:34244829 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.73 -0.58 7e-26 Total cholesterol levels; CESC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg25072359 chr17:41440525 NA 0.5 6.77 0.38 8.41e-11 Menopause (age at onset); CESC cis rs7607369 0.536 rs6436089 chr2:219668813 A/G cg02176678 chr2:219576539 TTLL4 -0.36 -6.16 -0.35 2.75e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14529146 chr17:39968600 FKBP10;SC65 -0.6 -6.71 -0.38 1.15e-10 Gut microbiome composition (summer); CESC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg21782813 chr7:2030301 MAD1L1 0.49 7.06 0.4 1.5e-11 Bipolar disorder and schizophrenia; CESC cis rs911555 0.723 rs56227024 chr14:103861706 A/G cg12935359 chr14:103987150 CKB 0.56 8.61 0.47 6.7e-16 Intelligence (multi-trait analysis); CESC cis rs2108225 0.967 rs7785790 chr7:107449896 C/T cg18560240 chr7:107437656 SLC26A3 0.4 5.5 0.32 9.09e-8 Ulcerative colitis; CESC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg06456125 chr7:65229604 NA -0.39 -5.1 -0.3 6.54e-7 Aortic root size; CESC cis rs7927592 0.871 rs17603185 chr11:68376241 C/T cg20283391 chr11:68216788 NA -0.6 -7.2 -0.4 6.05e-12 Total body bone mineral density; CESC trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg15704280 chr7:45808275 SEPT13 0.84 13.52 0.64 4.91e-32 Height; CESC cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg18512352 chr11:47633146 NA -0.6 -9.28 -0.5 6.06e-18 Subjective well-being; CESC cis rs2439831 0.867 rs486301 chr15:43836949 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.81 8.87 0.48 1.13e-16 Lung cancer in ever smokers; CESC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg02951883 chr7:2050386 MAD1L1 -0.5 -6.84 -0.39 5.53e-11 Bipolar disorder and schizophrenia; CESC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.62 0.33 4.92e-8 Bipolar disorder; CESC cis rs1691799 0.836 rs1184552 chr12:66756215 A/G cg16791601 chr12:66731901 HELB -0.79 -13.76 -0.65 7.13e-33 White blood cell count (basophil); CESC cis rs6570726 1.000 rs373778 chr6:145873252 C/T cg05347473 chr6:146136440 FBXO30 0.43 5.83 0.34 1.63e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs2046867 0.862 rs7648954 chr3:72838756 C/A cg25664220 chr3:72788482 NA -0.44 -6.47 -0.37 4.7e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs829883 0.622 rs4762498 chr12:98964737 A/G cg25150519 chr12:98850993 NA -0.61 -7.19 -0.4 6.71e-12 Colorectal adenoma (advanced); CESC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg09365446 chr1:150670422 GOLPH3L -0.43 -5.98 -0.34 7.25e-9 Tonsillectomy; CESC cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.56 0.32 6.57e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12691366 chr2:64681733 HSPC159 -0.52 -6.74 -0.38 9.95e-11 Asthma; CESC cis rs9611565 0.512 rs7291736 chr22:42124874 C/A cg17376030 chr22:41985996 PMM1 -0.79 -8.55 -0.46 1e-15 Vitiligo; CESC cis rs7084402 0.902 rs1649016 chr10:60288540 T/A cg07615347 chr10:60278583 BICC1 0.59 9.2 0.49 1.13e-17 Refractive error; CESC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg12463550 chr7:65579703 CRCP -0.48 -6.18 -0.35 2.45e-9 Aortic root size; CESC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg00908189 chr16:619842 PIGQ 0.64 8.84 0.48 1.35e-16 Height; CESC cis rs12545109 0.765 rs2438063 chr8:57384360 A/G cg19413350 chr8:57351067 NA 0.37 5.26 0.31 2.96e-7 Obesity-related traits; CESC cis rs470119 1.000 rs470119 chr22:50966914 C/T cg12969734 chr22:50962224 SCO2 -0.36 -5.53 -0.32 7.65e-8 Mean corpuscular hemoglobin; CESC cis rs6690583 0.562 rs11588919 chr1:85442813 A/T cg22153463 chr1:85462885 MCOLN2 0.77 7.26 0.41 4.35e-12 Serum sulfate level; CESC cis rs4474465 0.688 rs7942527 chr11:78280322 A/G cg27205649 chr11:78285834 NARS2 0.52 7.14 0.4 9.17e-12 Alzheimer's disease (survival time); CESC cis rs1559088 0.948 rs7247748 chr19:33594023 T/C cg27124370 chr19:33622961 WDR88 0.46 6.14 0.35 3.05e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6430585 0.528 rs6430594 chr2:136719173 C/T cg07169764 chr2:136633963 MCM6 -1.28 -19.81 -0.77 3.29e-54 Corneal structure; CESC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg05483915 chr17:80145575 CCDC57 0.45 5.38 0.31 1.68e-7 Breast cancer; CESC cis rs11250464 0.833 rs11250466 chr10:1409378 C/T cg08668359 chr10:1443807 ADARB2 0.59 7.35 0.41 2.44e-12 Radiation response; CESC cis rs1797885 0.934 rs12714871 chr3:12518729 T/C cg26432171 chr3:12704882 RAF1 -0.5 -6.28 -0.36 1.39e-9 Immature fraction of reticulocytes; CESC cis rs2777491 1.000 rs316609 chr15:41743828 T/A cg18705301 chr15:41695430 NDUFAF1 -0.65 -10.02 -0.52 3.12e-20 Ulcerative colitis; CESC cis rs10129255 0.518 rs10150460 chr14:107133196 C/G cg07470598 chr14:107239068 NA -0.35 -5.05 -0.3 8.26e-7 Kawasaki disease; CESC cis rs3126085 0.867 rs36033453 chr1:152221226 T/G cg26876637 chr1:152193138 HRNR -0.45 -5.11 -0.3 6.14e-7 Atopic dermatitis; CESC cis rs4253772 0.550 rs55926596 chr22:46682955 C/T cg10541313 chr22:46663664 TTC38 0.79 5.78 0.33 2.13e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4253772 0.530 rs9615990 chr22:46804154 G/A cg00784671 chr22:46762841 CELSR1 -0.48 -5.1 -0.3 6.34e-7 LDL cholesterol;Cholesterol, total; CESC cis rs35123781 0.696 rs356429 chr5:139073143 C/T cg10513866 chr5:139070639 NA 0.42 5.84 0.34 1.55e-8 Schizophrenia; CESC cis rs6752107 1.000 rs10165561 chr2:234172915 G/C cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.36 5.43 0.32 1.25e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.33 5.36 0.31 1.81e-7 Monocyte percentage of white cells; CESC cis rs6723226 0.750 rs10182170 chr2:32704186 G/A cg02381751 chr2:32503542 YIPF4 0.78 11.02 0.56 1.64e-23 Intelligence (multi-trait analysis); CESC trans rs116095464 0.558 rs9687621 chr5:229194 C/T cg00938859 chr5:1591904 SDHAP3 0.69 6.39 0.37 7.33e-10 Breast cancer; CESC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg17178900 chr1:205818956 PM20D1 0.8 13.19 0.63 7.15e-31 Menarche (age at onset); CESC cis rs61996546 0.622 rs12912641 chr15:26844242 C/T cg15066197 chr15:26874202 GABRB3 -0.34 -5.09 -0.3 6.78e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.17e-12 Tonsillectomy; CESC cis rs9300255 0.508 rs1716176 chr12:123655467 T/G cg00376283 chr12:123451042 ABCB9 0.7 8.57 0.47 8.55e-16 Neutrophil percentage of white cells; CESC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg17971929 chr21:40555470 PSMG1 -0.85 -12.28 -0.6 9.53e-28 Cognitive function; CESC cis rs34638657 0.687 rs2303261 chr16:82203768 G/T cg09439754 chr16:82129088 HSD17B2 -0.35 -6.17 -0.35 2.57e-9 Lung adenocarcinoma; CESC cis rs4642101 0.737 rs6767504 chr3:12826667 C/T cg24848339 chr3:12840334 CAND2 0.38 5.8 0.34 1.89e-8 QRS complex (12-leadsum); CESC cis rs9487051 0.597 rs9400265 chr6:109594932 A/C cg01475377 chr6:109611718 NA -0.39 -5.04 -0.3 8.81e-7 Reticulocyte fraction of red cells; CESC cis rs6754311 0.731 rs6719488 chr2:136575199 G/T cg07169764 chr2:136633963 MCM6 -0.66 -7.98 -0.44 4.39e-14 Mosquito bite size; CESC cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg06212747 chr3:49208901 KLHDC8B 0.71 9.33 0.5 4.55e-18 Parkinson's disease; CESC cis rs9910055 0.659 rs8079310 chr17:42270291 A/G cg08499158 chr17:42289980 UBTF -0.48 -6.01 -0.35 6.1e-9 Total body bone mineral density; CESC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg26354017 chr1:205819088 PM20D1 0.44 6.05 0.35 4.8e-9 Menarche (age at onset); CESC cis rs6540556 0.954 rs3753606 chr1:209937212 C/T cg05527609 chr1:210001259 C1orf107 0.5 6.25 0.36 1.66e-9 Red blood cell count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19857114 chr3:176741225 TBL1XR1 -0.48 -6.21 -0.36 2.01e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg09177884 chr7:1199841 ZFAND2A -0.65 -8.68 -0.47 4.06e-16 Longevity;Endometriosis; CESC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.24 0.36 1.69e-9 Menopause (age at onset); CESC cis rs854765 0.618 rs8068820 chr17:17834119 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.17 0.45 1.29e-14 Total body bone mineral density; CESC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg04414720 chr1:150670196 GOLPH3L 0.55 7.37 0.41 2.11e-12 Melanoma; CESC cis rs2404602 0.692 rs55729975 chr15:76803226 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.66 -0.33 3.91e-8 Blood metabolite levels; CESC cis rs4629710 0.568 rs9492880 chr6:131565962 G/T cg12606694 chr6:131520996 AKAP7 0.47 5.76 0.33 2.33e-8 Multiple myeloma (IgH translocation); CESC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg04267008 chr7:1944627 MAD1L1 -0.61 -7.4 -0.41 1.75e-12 Bipolar disorder and schizophrenia; CESC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg24675658 chr1:53192096 ZYG11B -0.61 -7.54 -0.42 7.33e-13 Monocyte count; CESC cis rs7772486 0.875 rs10457794 chr6:146415608 A/G cg23711669 chr6:146136114 FBXO30 0.86 12.72 0.62 2.98e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg18512352 chr11:47633146 NA -0.52 -7.6 -0.42 5.17e-13 Subjective well-being; CESC cis rs1126510 0.897 rs12459883 chr19:47126614 C/G cg07844738 chr19:47129343 PTGIR 0.32 5.12 0.3 5.83e-7 Ulcerative colitis; CESC cis rs2637266 0.875 rs115333453 chr10:78369011 G/A cg18941641 chr10:78392320 NA 0.4 7.49 0.42 1.02e-12 Pulmonary function; CESC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.81 0.39 6.45e-11 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.10.1020819F chr10:44585416 NA 0.49 7.0 0.4 2.04e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12422267 0.536 rs12423631 chr12:132606886 C/T cg09764611 chr12:132620959 NA -0.57 -6.79 -0.38 7.52e-11 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs477895 0.838 rs72922039 chr11:64013116 A/C cg04317338 chr11:64019027 PLCB3 0.92 10.01 0.52 3.13e-20 Mean platelet volume; CESC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.73 0.38 1.05e-10 Prudent dietary pattern; CESC cis rs2295499 0.903 rs16843281 chr4:2721132 C/G cg08330972 chr4:2403930 ZFYVE28 0.31 5.13 0.3 5.59e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02889909 chr14:75760889 NA 0.62 7.06 0.4 1.48e-11 Gut microbiome composition (summer); CESC cis rs3741151 0.773 rs7925226 chr11:73137362 A/G cg17517138 chr11:73019481 ARHGEF17 0.94 6.86 0.39 4.87e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs6061231 0.793 rs2427320 chr20:60976723 A/G cg06197360 chr20:60970103 CABLES2 -0.47 -5.57 -0.32 6.32e-8 Colorectal cancer; CESC cis rs1506636 0.962 rs7811830 chr7:123320183 G/C cg03229431 chr7:123269106 ASB15 -0.51 -6.74 -0.38 9.6e-11 Plateletcrit;Platelet count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07636870 chr10:104262614 SUFU;ACTR1A 0.45 6.07 0.35 4.46e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg09074113 chr2:20870087 GDF7 0.39 6.77 0.38 8.18e-11 Abdominal aortic aneurysm; CESC cis rs4654899 0.865 rs61779075 chr1:21417027 T/C cg05370193 chr1:21551575 ECE1 0.45 6.78 0.38 7.88e-11 Superior frontal gyrus grey matter volume; CESC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg03806693 chr22:41940476 POLR3H 1.19 14.07 0.65 5.68e-34 Vitiligo; CESC cis rs6439153 0.933 rs11711812 chr3:128708554 G/A cg25356066 chr3:128598488 ACAD9 0.55 7.17 0.4 7.55e-12 Pneumococcal bacteremia; CESC cis rs72781680 0.898 rs72780118 chr2:23994431 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs4423214 0.515 rs4944042 chr11:71118788 C/A cg05163923 chr11:71159392 DHCR7 0.56 7.34 0.41 2.6e-12 Vitamin D levels; CESC cis rs2243480 0.708 rs13242216 chr7:65898277 T/C cg18252515 chr7:66147081 NA -1.41 -14.24 -0.66 1.46e-34 Diabetic kidney disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03552401 chr19:54974983 LENG9 -0.51 -6.74 -0.38 9.91e-11 Fibrinogen levels; CESC cis rs11997175 0.902 rs7462140 chr8:33717880 A/G ch.8.33884649F chr8:33765107 NA 0.62 7.94 0.44 5.75e-14 Body mass index; CESC cis rs2273669 0.588 rs12201102 chr6:109317388 A/G cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs9611565 0.649 rs126092 chr22:42178441 A/G cg06481639 chr22:41940642 POLR3H 0.48 5.36 0.31 1.78e-7 Vitiligo; CESC cis rs2594714 0.515 rs10411270 chr19:13940838 A/T cg18576835 chr19:13944261 NA -0.39 -5.08 -0.3 7.01e-7 Breast cancer; CESC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.71 0.38 1.17e-10 Intelligence (multi-trait analysis); CESC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg18402987 chr7:1209562 NA 0.64 6.85 0.39 5.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg19932523 chr11:72145623 CLPB -0.49 -6.56 -0.37 2.81e-10 Height; CESC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg24101359 chr6:42928495 GNMT 0.6 8.91 0.48 8.14e-17 Alzheimer's disease in APOE e4+ carriers; CESC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs4835473 0.932 rs13129702 chr4:144706285 C/T cg25736465 chr4:144833511 NA 0.31 5.03 0.3 8.85e-7 Immature fraction of reticulocytes; CESC cis rs4474465 0.850 rs4559714 chr11:78257302 C/T cg27205649 chr11:78285834 NARS2 0.42 5.4 0.31 1.49e-7 Alzheimer's disease (survival time); CESC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg06505273 chr16:24850292 NA 0.5 5.59 0.32 5.78e-8 Intelligence (multi-trait analysis); CESC cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg10523679 chr1:76189770 ACADM 0.67 7.61 0.42 4.79e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg06558623 chr16:89946397 TCF25 0.68 5.89 0.34 1.17e-8 Skin colour saturation; CESC cis rs11098499 0.866 rs12374352 chr4:120281977 C/T cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs6120849 0.754 rs3818253 chr20:33596876 C/T cg24642439 chr20:33292090 TP53INP2 0.67 6.74 0.38 9.78e-11 Protein C levels; CESC cis rs4481887 0.927 rs4307598 chr1:248474544 T/C cg00666640 chr1:248458726 OR2T12 0.36 6.12 0.35 3.33e-9 Common traits (Other); CESC cis rs7223966 1.000 rs28463311 chr17:61919643 C/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.14 -0.3 5.4e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs977987 0.645 rs10871311 chr16:75450912 T/A cg03315344 chr16:75512273 CHST6 0.4 5.77 0.33 2.17e-8 Dupuytren's disease; CESC cis rs7312774 0.529 rs12314792 chr12:107333672 T/C cg16260113 chr12:107380972 MTERFD3 0.79 7.12 0.4 9.88e-12 Severe influenza A (H1N1) infection; CESC trans rs4332037 0.851 rs1403175 chr7:1964357 A/T cg11693508 chr17:37793320 STARD3 -0.66 -6.56 -0.37 2.79e-10 Bipolar disorder; CESC cis rs7692995 1.000 rs11936911 chr4:17948668 A/G cg08925142 chr4:18023851 LCORL -0.46 -5.42 -0.32 1.34e-7 Height; CESC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg03709012 chr19:19516395 GATAD2A 0.97 15.05 0.68 2.07e-37 Tonsillectomy; CESC cis rs6831352 0.959 rs6532795 chr4:100042221 C/T cg13256891 chr4:100009986 ADH5 -0.7 -8.07 -0.44 2.47e-14 Alcohol dependence; CESC cis rs6964587 0.692 rs418 chr7:91583334 C/T cg17063962 chr7:91808500 NA -0.45 -6.23 -0.36 1.84e-9 Breast cancer; CESC cis rs1957429 0.901 rs59876171 chr14:65384429 C/T cg23373153 chr14:65346875 NA -0.9 -9.7 -0.51 3.21e-19 Pediatric areal bone mineral density (radius); CESC cis rs12681288 0.792 rs12678495 chr8:1000858 C/G cg04851639 chr8:1020857 NA -0.32 -7.17 -0.4 7.66e-12 Schizophrenia; CESC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg23281280 chr6:28129359 ZNF389 0.59 7.88 0.44 8.68e-14 Depression; CESC cis rs8114671 0.967 rs2069952 chr20:33763951 C/T cg24642439 chr20:33292090 TP53INP2 0.44 5.37 0.31 1.73e-7 Height; CESC cis rs9359856 0.564 rs72913976 chr6:90390233 T/C cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.38 -0.36 7.94e-10 Bipolar disorder; CESC cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg07697082 chr8:82753677 SNX16 0.36 5.54 0.32 7.16e-8 Diastolic blood pressure; CESC cis rs9378357 0.850 rs9391986 chr6:3290583 A/G cg08754725 chr6:3293098 SLC22A23 0.62 5.06 0.3 7.85e-7 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19806062 chr19:11319688 DOCK6 0.47 6.38 0.36 7.91e-10 Fibrinogen levels; CESC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg18404041 chr3:52824283 ITIH1 0.35 6.16 0.35 2.69e-9 Bipolar disorder; CESC cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg18512352 chr11:47633146 NA -0.52 -7.44 -0.42 1.38e-12 Subjective well-being; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06498398 chr8:11627480 NEIL2 -0.45 -6.54 -0.37 3.11e-10 Gambling; CESC trans rs7618501 0.699 rs2681781 chr3:49898273 A/G cg21659725 chr3:3221576 CRBN 0.59 8.31 0.45 5.04e-15 Intelligence (multi-trait analysis); CESC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg11965913 chr1:205819406 PM20D1 0.81 13.37 0.63 1.63e-31 Menarche (age at onset); CESC cis rs9556958 0.588 rs9556964 chr13:99159306 T/C cg20750642 chr13:99100586 FARP1 0.39 6.29 0.36 1.33e-9 Educational attainment (years of education); CESC cis rs7539624 0.588 rs28370014 chr1:223903167 A/G cg10100437 chr1:223903862 CAPN2 0.41 5.27 0.31 2.77e-7 Schizophrenia; CESC cis rs870825 0.550 rs57301026 chr4:185646505 C/G cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs7662987 0.517 rs2602877 chr4:100039847 T/A cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC cis rs17125944 0.505 rs75661138 chr14:53259262 G/A cg13660082 chr14:53194042 PSMC6 -0.66 -5.7 -0.33 3.26e-8 Alzheimer's disease (late onset); CESC cis rs8067354 0.958 rs8081468 chr17:57836924 A/G cg13753209 chr17:57696993 CLTC 0.51 6.85 0.39 5.04e-11 Hemoglobin concentration; CESC cis rs7312933 0.533 rs17551006 chr12:42848738 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.34 0.36 9.95e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.19e-8 Lung cancer; CESC cis rs6582630 0.555 rs10880544 chr12:38473464 G/C cg26384229 chr12:38710491 ALG10B 0.71 10.82 0.55 7.82e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.54 -0.37 3.18e-10 Bipolar disorder; CESC cis rs6963495 0.818 rs56165465 chr7:105180384 C/T cg02135003 chr7:105160482 PUS7 -0.42 -5.42 -0.32 1.34e-7 Bipolar disorder (body mass index interaction); CESC cis rs8018808 0.935 rs176772 chr14:77881808 A/G cg20045696 chr14:77926864 AHSA1 0.5 6.97 0.39 2.55e-11 Myeloid white cell count; CESC cis rs9911578 0.967 rs11656413 chr17:57082013 A/C cg05425664 chr17:57184151 TRIM37 0.51 7.0 0.4 2.04e-11 Intelligence (multi-trait analysis); CESC cis rs888194 0.568 rs10850141 chr12:109876128 C/T cg19025524 chr12:109796872 NA -0.39 -5.35 -0.31 1.86e-7 Neuroticism; CESC cis rs8180040 0.764 rs4683324 chr3:47251284 T/C cg27129171 chr3:47204927 SETD2 0.7 10.58 0.55 4.6e-22 Colorectal cancer; CESC cis rs7959452 0.570 rs10878964 chr12:69720691 T/G cg22834771 chr12:69754056 YEATS4 -0.4 -5.13 -0.3 5.49e-7 Blood protein levels; CESC cis rs2732480 0.577 rs2634681 chr12:48733084 C/T cg24011408 chr12:48396354 COL2A1 -0.39 -5.73 -0.33 2.73e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.36 0.31 1.84e-7 Cognitive function; CESC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.59 0.32 5.58e-8 Bipolar disorder; CESC cis rs72781680 0.784 rs12616678 chr2:24181159 G/T cg08917208 chr2:24149416 ATAD2B 0.66 6.5 0.37 3.98e-10 Lymphocyte counts; CESC cis rs2898857 0.545 rs12602382 chr17:47356805 C/A cg08112188 chr17:47440006 ZNF652 0.46 5.79 0.34 1.97e-8 Cancer; CESC cis rs3540 0.597 rs1978151 chr15:91037300 C/T cg22089800 chr15:90895588 ZNF774 0.63 8.35 0.46 3.82e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06861343 chr3:52739491 GLT8D1;SPCS1 0.44 6.14 0.35 3.05e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9457247 0.663 rs9459835 chr6:167417551 G/T cg25258033 chr6:167368657 RNASET2 0.36 5.16 0.3 4.87e-7 Crohn's disease; CESC cis rs1801251 1.000 rs1947105 chr2:233721455 A/G cg25237894 chr2:233734115 C2orf82 0.47 8.14 0.45 1.57e-14 Coronary artery disease; CESC trans rs2727020 0.595 rs11040416 chr11:49566429 C/T cg15704280 chr7:45808275 SEPT13 -0.95 -17.21 -0.73 4.31e-45 Coronary artery disease; CESC cis rs7561273 0.586 rs4149372 chr2:24305512 T/G cg06627628 chr2:24431161 ITSN2 -0.48 -5.62 -0.33 4.91e-8 Quantitative traits; CESC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg12463550 chr7:65579703 CRCP -0.56 -7.25 -0.41 4.5e-12 Aortic root size; CESC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg18446336 chr7:2847575 GNA12 0.39 5.96 0.34 8.22e-9 Height; CESC cis rs589448 0.902 rs315134 chr12:69762713 G/A cg14784868 chr12:69753453 YEATS4 0.89 14.23 0.66 1.66e-34 Cerebrospinal fluid biomarker levels; CESC cis rs2370759 0.945 rs3740237 chr10:32557592 G/C cg18270830 chr10:32634957 EPC1 0.67 5.25 0.31 3.19e-7 Sexual dysfunction (female); CESC cis rs35771425 0.619 rs7538812 chr1:211442186 A/G cg25617285 chr1:211431773 RCOR3 -0.38 -5.34 -0.31 2e-7 Educational attainment (years of education); CESC cis rs2463822 1.000 rs1881534 chr11:62085083 A/G cg06239285 chr11:62104954 ASRGL1 0.99 8.89 0.48 9.58e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2637266 0.561 rs11492375 chr10:78513974 T/C cg18941641 chr10:78392320 NA -0.32 -5.12 -0.3 5.96e-7 Pulmonary function; CESC cis rs12618769 0.656 rs56091613 chr2:99103761 A/G cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Parkinson's disease; CESC cis rs2073300 0.609 rs2277765 chr20:23425163 C/T cg16736954 chr20:23401023 NAPB 0.73 5.23 0.31 3.38e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs11098499 0.780 rs10013652 chr4:120292256 A/G cg24375607 chr4:120327624 NA 0.43 5.26 0.31 3.02e-7 Corneal astigmatism; CESC cis rs9611565 0.559 rs9611619 chr22:41986714 C/T cg06634786 chr22:41940651 POLR3H -0.67 -6.46 -0.37 4.85e-10 Vitiligo; CESC cis rs11168351 0.926 rs10875719 chr12:48411158 T/C cg24011408 chr12:48396354 COL2A1 0.53 8.03 0.44 3.26e-14 Bipolar disorder and schizophrenia; CESC cis rs9910055 0.540 rs609292 chr17:42180436 G/A cg13607699 chr17:42295918 UBTF -0.56 -7.35 -0.41 2.47e-12 Total body bone mineral density; CESC trans rs8073060 0.504 rs225271 chr17:33969836 C/T cg19694781 chr19:47549865 TMEM160 -0.72 -7.25 -0.41 4.51e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg25036284 chr2:26402008 FAM59B -0.74 -8.4 -0.46 2.72e-15 Gut microbiome composition (summer); CESC cis rs8141529 0.719 rs9625619 chr22:29272328 T/A cg15103426 chr22:29168792 CCDC117 0.62 8.01 0.44 3.62e-14 Lymphocyte counts; CESC cis rs950027 0.620 rs1719245 chr15:45623782 T/C cg21132104 chr15:45694354 SPATA5L1 0.68 8.74 0.47 2.81e-16 Response to fenofibrate (adiponectin levels); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04703844 chr8:74207197 RPL7;RDH10 0.49 6.19 0.36 2.31e-9 Gut microbiota (bacterial taxa); CESC cis rs854765 0.583 rs5002487 chr17:17832460 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.49 6.82 0.39 6.31e-11 Total body bone mineral density; CESC cis rs9346455 1.000 rs9342830 chr6:72024809 T/A cg27238071 chr6:71998145 OGFRL1 0.61 5.27 0.31 2.9e-7 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs10256972 0.869 rs13236369 chr7:1033799 G/T cg23978390 chr7:1156363 C7orf50 0.4 5.29 0.31 2.55e-7 Longevity;Endometriosis; CESC cis rs7843479 0.511 rs4379446 chr8:21777595 C/G cg17168535 chr8:21777572 XPO7 0.74 12.02 0.59 7.45e-27 Mean corpuscular volume; CESC cis rs7520050 0.808 rs11211196 chr1:46282296 A/T cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.38e-7 Red blood cell count;Reticulocyte count; CESC cis rs9911578 0.967 rs2611781 chr17:56703124 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.07 0.3 7.52e-7 Intelligence (multi-trait analysis); CESC cis rs4523957 0.788 rs11651451 chr17:2098417 C/T cg16513277 chr17:2031491 SMG6 -0.57 -7.84 -0.43 1.13e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11122272 0.735 rs2739513 chr1:231515201 C/T cg06096015 chr1:231504339 EGLN1 0.45 6.39 0.37 7.53e-10 Hemoglobin concentration; CESC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Parkinson's disease; CESC cis rs2749592 0.531 rs10764134 chr10:37856660 T/C cg00409905 chr10:38381863 ZNF37A 0.42 5.51 0.32 8.48e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs79839061 0.610 rs62297087 chr4:913289 T/A cg07828340 chr4:882639 GAK 0.99 7.03 0.4 1.78e-11 Intelligence (multi-trait analysis); CESC cis rs7772486 0.764 rs9399569 chr6:146242942 C/T cg05347473 chr6:146136440 FBXO30 -0.53 -6.92 -0.39 3.46e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg11450001 chr12:10365596 GABARAPL1 0.49 6.5 0.37 3.87e-10 Breast cancer;Type 2 diabetes; CESC cis rs7605827 0.704 rs3732001 chr2:15536872 T/C cg19274914 chr2:15703543 NA 0.35 6.39 0.37 7.22e-10 Educational attainment (years of education); CESC cis rs9486719 0.947 rs12208556 chr6:96903486 C/T cg18709589 chr6:96969512 KIAA0776 -0.48 -5.48 -0.32 1e-7 Migraine;Coronary artery disease; CESC cis rs7713065 1.000 rs3749833 chr5:131799626 T/C cg09877947 chr5:131593287 PDLIM4 -0.44 -5.1 -0.3 6.33e-7 Lung function (FEV1/FVC); CESC cis rs6120849 0.707 rs6120799 chr20:33614955 T/C cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs13392177 0.684 rs11695527 chr2:219068103 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.52 6.62 0.38 1.99e-10 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs9323205 0.911 rs12587611 chr14:51641399 C/T cg23942311 chr14:51606299 NA -0.41 -5.73 -0.33 2.69e-8 Cancer; CESC cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg00522288 chr12:125625016 AACS -0.31 -5.04 -0.3 8.49e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg18446336 chr7:2847575 GNA12 -0.34 -5.46 -0.32 1.1e-7 Height; CESC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg18512352 chr11:47633146 NA -0.42 -6.13 -0.35 3.12e-9 Subjective well-being; CESC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs56342538 chr5:225796 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.65 0.33 4.24e-8 Breast cancer; CESC cis rs9916302 0.706 rs8069074 chr17:37685401 C/T cg07936489 chr17:37558343 FBXL20 0.95 11.17 0.57 5.24e-24 Glomerular filtration rate (creatinine); CESC cis rs7527798 0.592 rs960087 chr1:207826858 C/G cg21110645 chr1:207815933 NA -0.33 -5.66 -0.33 3.83e-8 Erythrocyte sedimentation rate; CESC cis rs7927771 0.524 rs4752860 chr11:47705015 C/A cg20307385 chr11:47447363 PSMC3 -0.57 -7.85 -0.43 1.02e-13 Subjective well-being; CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.61 -0.33 5.04e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg03467027 chr4:99064603 C4orf37 0.48 6.09 0.35 4.06e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2880765 0.835 rs12708553 chr15:86046833 C/G cg10818794 chr15:86012489 AKAP13 0.35 5.35 0.31 1.89e-7 Coronary artery disease; CESC cis rs6696846 0.749 rs7553876 chr1:205079915 A/G cg00857998 chr1:205179979 DSTYK 0.5 6.85 0.39 5.06e-11 Red blood cell count; CESC cis rs9303401 0.614 rs2007993 chr17:56590643 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.53 0.61 1.36e-28 Cognitive test performance; CESC cis rs7772486 0.875 rs2777477 chr6:146305491 A/G cg05347473 chr6:146136440 FBXO30 0.53 7.12 0.4 1.02e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs17376456 1.000 rs34068652 chr5:93563319 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.05 0.3 8.14e-7 Diabetic retinopathy; CESC cis rs6674176 0.597 rs4660262 chr1:44382524 G/A cg12908607 chr1:44402522 ARTN -0.51 -7.86 -0.43 9.86e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7216064 0.954 rs4790973 chr17:65951133 C/T cg12091567 chr17:66097778 LOC651250 -0.7 -7.16 -0.4 7.85e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg18876405 chr7:65276391 NA -0.57 -7.55 -0.42 6.85e-13 Aortic root size; CESC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg08847533 chr14:75593920 NEK9 -1.0 -18.88 -0.76 5.99e-51 Height; CESC cis rs28374715 0.532 rs316607 chr15:41772693 G/A cg18705301 chr15:41695430 NDUFAF1 -1.08 -17.26 -0.73 2.91e-45 Ulcerative colitis; CESC cis rs924607 1.000 rs11746907 chr5:598224 G/A cg09021430 chr5:549028 NA 0.38 6.64 0.38 1.81e-10 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg20243544 chr17:37824526 PNMT 0.49 6.03 0.35 5.46e-9 Glomerular filtration rate (creatinine); CESC cis rs921968 0.643 rs62191565 chr2:219482017 C/T cg02176678 chr2:219576539 TTLL4 0.38 6.7 0.38 1.23e-10 Mean corpuscular hemoglobin concentration; CESC cis rs2066819 0.892 rs17118431 chr12:56667100 A/G cg26714650 chr12:56694279 CS -1.41 -9.99 -0.52 3.69e-20 Psoriasis vulgaris; CESC cis rs56399783 0.901 rs17132624 chr7:2778496 G/A cg19731401 chr7:2775893 GNA12 0.68 6.14 0.35 3.07e-9 Childhood ear infection; CESC cis rs4253772 0.591 rs6008545 chr22:46686375 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.72 7.97 0.44 4.75e-14 LDL cholesterol;Cholesterol, total; CESC cis rs2354432 1.000 rs10900325 chr1:146692174 C/T cg25205988 chr1:146714368 CHD1L -1.06 -11.38 -0.57 1.06e-24 Mitochondrial DNA levels; CESC trans rs61931739 0.517 rs11053063 chr12:34181011 C/T cg26384229 chr12:38710491 ALG10B 0.65 9.11 0.49 2.1e-17 Morning vs. evening chronotype; CESC cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg05776053 chr2:74358815 NA 0.4 5.05 0.3 8.18e-7 Gestational age at birth (maternal effect); CESC cis rs4474465 0.688 rs7108439 chr11:78277708 A/T cg27205649 chr11:78285834 NARS2 0.48 6.3 0.36 1.27e-9 Alzheimer's disease (survival time); CESC cis rs9300255 0.512 rs2851436 chr12:123667354 G/T cg19016782 chr12:123741754 C12orf65 -0.45 -6.21 -0.36 2.01e-9 Neutrophil percentage of white cells; CESC cis rs3126085 0.935 rs10788824 chr1:152161694 A/G cg03465714 chr1:152285911 FLG -0.44 -5.36 -0.31 1.85e-7 Atopic dermatitis; CESC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg05863683 chr7:1912471 MAD1L1 0.35 5.12 0.3 5.82e-7 Schizophrenia; CESC cis rs62408225 1.000 rs11757155 chr6:90941240 C/T cg06866423 chr6:90926672 BACH2 0.48 5.99 0.35 6.93e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs796364 0.951 rs59695400 chr2:201021325 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -6.67 -0.38 1.5e-10 Schizophrenia; CESC cis rs12477438 0.501 rs6542868 chr2:99782848 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.84 0.62 1.16e-29 Chronic sinus infection; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11688874 chr10:28822482 WAC 0.48 6.5 0.37 3.97e-10 Gut microbiota (bacterial taxa); CESC trans rs324780 0.544 rs3112096 chr12:83887311 C/T cg22140261 chr22:42466895 NAGA 0.47 6.03 0.35 5.38e-9 Vertical cup-disc ratio; CESC cis rs911555 0.755 rs8010247 chr14:103933556 A/G cg12935359 chr14:103987150 CKB 0.66 9.68 0.51 3.48e-19 Intelligence (multi-trait analysis); CESC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg00738919 chr7:1100172 C7orf50 0.54 5.46 0.32 1.07e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs1814175 0.715 rs7479622 chr11:49673340 T/G cg15704280 chr7:45808275 SEPT13 -1.0 -17.79 -0.74 4.02e-47 Height; CESC cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg06203126 chr5:43313815 HMGCS1 0.42 6.04 0.35 5.18e-9 Positive affect; CESC cis rs4843747 0.697 rs72818533 chr16:88073841 G/A cg17633681 chr16:88106987 BANP 0.71 9.22 0.49 9.71e-18 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07218578 chr22:31556156 RNF185 0.63 6.79 0.38 7.35e-11 Gut microbiome composition (summer); CESC cis rs1153858 1.000 rs11070456 chr15:45686835 G/A cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.71e-25 Homoarginine levels; CESC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs7071206 0.704 rs11002234 chr10:79434458 A/G cg00983440 chr10:79422392 NA -0.57 -7.04 -0.4 1.64e-11 Bone mineral density; CESC cis rs3026101 0.671 rs748486 chr17:5290824 C/A cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.69 0.33 3.37e-8 Body mass index; CESC trans rs9833726 0.799 rs7623220 chr3:86140049 G/A cg10416071 chr15:75628863 COMMD4 0.59 6.12 0.35 3.37e-9 Breast cancer; CESC cis rs12136530 0.577 rs4481878 chr1:19791086 C/A cg01832549 chr1:19774989 CAPZB 0.37 5.25 0.31 3.17e-7 Lead levels in blood; CESC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg13647721 chr17:30228624 UTP6 0.6 5.49 0.32 9.34e-8 Hip circumference adjusted for BMI; CESC trans rs61931739 0.500 rs10844844 chr12:34380350 G/T cg26384229 chr12:38710491 ALG10B 0.67 10.1 0.53 1.64e-20 Morning vs. evening chronotype; CESC cis rs9640161 0.742 rs2108852 chr7:150019628 T/C cg21361702 chr7:150065534 REPIN1 0.56 6.54 0.37 3.2e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs9811920 0.514 rs1287283 chr3:99515750 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 5.33 0.31 2.12e-7 Axial length; CESC cis rs17572109 0.666 rs4674297 chr2:219229147 A/G cg00012203 chr2:219082015 ARPC2 0.51 5.36 0.31 1.79e-7 Platelet count;Platelet distribution width;Mean platelet volume; CESC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.54 -0.32 7.28e-8 Lung cancer; CESC cis rs8072100 0.905 rs8078686 chr17:45735706 T/C cg08085267 chr17:45401833 C17orf57 0.44 5.79 0.33 2.02e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs868036 0.918 rs4776967 chr15:68033922 T/C cg08079166 chr15:68083412 MAP2K5 0.42 6.52 0.37 3.47e-10 Restless legs syndrome; CESC cis rs7267979 1.000 rs6132835 chr20:25434667 A/G cg08601574 chr20:25228251 PYGB 0.38 5.42 0.32 1.37e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25228510 chr10:62538235 CDK1;CDC2 -0.49 -6.53 -0.37 3.42e-10 Ulcerative colitis; CESC cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13495574 chr1:173793781 CENPL;DARS2 0.55 6.35 0.36 9.49e-10 Gut microbiome composition (summer); CESC cis rs916888 0.821 rs199506 chr17:44859031 A/G cg17911788 chr17:44343683 NA 0.55 7.39 0.41 1.92e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9660992 0.573 rs12126439 chr1:205200720 C/T cg21643547 chr1:205240462 TMCC2 -0.39 -5.37 -0.31 1.76e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs8114671 0.935 rs6058198 chr20:33748253 T/A cg24642439 chr20:33292090 TP53INP2 0.43 5.11 0.3 6.32e-7 Height; CESC cis rs9911578 0.967 rs1588322 chr17:56990099 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.05 0.3 8.26e-7 Intelligence (multi-trait analysis); CESC cis rs7727544 0.618 rs2631367 chr5:131705458 C/G cg14196790 chr5:131705035 SLC22A5 -0.43 -6.6 -0.38 2.21e-10 Blood metabolite levels; CESC cis rs754466 0.580 rs12354903 chr10:79536465 T/C cg17075019 chr10:79541650 NA -0.87 -13.57 -0.64 3.29e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs61931739 0.500 rs12829125 chr12:34314789 A/G cg26384229 chr12:38710491 ALG10B 0.63 8.95 0.48 6.59e-17 Morning vs. evening chronotype; CESC cis rs3767633 0.925 rs10753666 chr1:161861147 C/G cg09175582 chr1:161736000 ATF6 0.86 6.95 0.39 2.83e-11 IgG glycosylation; CESC cis rs2050392 1.000 rs2050392 chr10:30691503 G/A cg25182066 chr10:30743637 MAP3K8 -0.38 -5.08 -0.3 6.99e-7 Inflammatory bowel disease; CESC cis rs1707322 1.000 rs4660906 chr1:46470860 C/T cg06784218 chr1:46089804 CCDC17 0.35 5.9 0.34 1.09e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7584330 0.740 rs13418586 chr2:238445593 A/G cg14458575 chr2:238380390 NA 0.5 7.47 0.42 1.14e-12 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25730142 chr20:32031702 SNTA1 0.57 6.71 0.38 1.17e-10 Gut microbiome composition (summer); CESC cis rs2204008 0.837 rs11169157 chr12:37980047 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.51 0.5 1.2e-18 Bladder cancer; CESC cis rs3960554 0.610 rs10265696 chr7:75766712 G/A cg17325771 chr7:75508891 RHBDD2 -0.34 -5.06 -0.3 7.71e-7 Eotaxin levels; CESC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg12463550 chr7:65579703 CRCP 0.51 6.41 0.37 6.58e-10 Aortic root size; CESC cis rs2204008 0.805 rs11179579 chr12:38213957 A/C cg13010199 chr12:38710504 ALG10B 0.51 6.45 0.37 5.18e-10 Bladder cancer; CESC cis rs10789491 1.000 rs10749863 chr1:47174328 C/T cg15501359 chr1:47185051 KIAA0494 0.79 9.02 0.48 4.04e-17 Response to hepatitis C treatment; CESC cis rs5753618 0.504 rs9606846 chr22:31897571 C/T cg13145458 chr22:31556086 RNF185 -0.53 -6.2 -0.36 2.11e-9 Colorectal cancer; CESC cis rs1707322 1.000 rs2458400 chr1:46530798 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.55 -0.32 7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2952156 0.920 rs9675194 chr17:37833805 A/G cg00129232 chr17:37814104 STARD3 -0.74 -10.88 -0.56 4.97e-23 Asthma; CESC cis rs9457247 0.663 rs9459839 chr6:167431829 T/C cg07741184 chr6:167504864 NA 0.34 6.07 0.35 4.41e-9 Crohn's disease; CESC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg05313129 chr8:58192883 C8orf71 -0.54 -6.25 -0.36 1.68e-9 Developmental language disorder (linguistic errors); CESC cis rs8028182 0.636 rs28737338 chr15:75768679 C/T cg20655648 chr15:75932815 IMP3 0.48 6.1 0.35 3.77e-9 Sudden cardiac arrest; CESC cis rs9388451 0.839 rs3799709 chr6:126078361 A/G cg10911889 chr6:126070802 HEY2 0.38 5.22 0.31 3.54e-7 Brugada syndrome; CESC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg26839252 chr6:160211577 TCP1;MRPL18 0.49 6.14 0.35 3.08e-9 Age-related macular degeneration (geographic atrophy); CESC cis rs11971779 0.793 rs11772447 chr7:139033589 T/G cg07862535 chr7:139043722 LUC7L2 0.52 5.8 0.34 1.87e-8 Diisocyanate-induced asthma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17250947 chr3:42642016 NKTR -0.42 -6.03 -0.35 5.43e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs57506017 0.606 rs7797705 chr7:12277773 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.17 0.3 4.51e-7 Neuroticism; CESC cis rs8072100 0.748 rs9908016 chr17:45551361 G/A cg25173405 chr17:45401733 C17orf57 -0.47 -6.16 -0.35 2.75e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs654950 0.774 rs941972 chr1:42040740 T/C cg06885757 chr1:42089581 HIVEP3 -0.63 -10.19 -0.53 8.56e-21 Airway imaging phenotypes; CESC cis rs7524258 0.868 rs2157499 chr1:7271472 C/T cg07173049 chr1:7289937 CAMTA1 0.38 5.62 0.33 4.74e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs3026101 0.578 rs59605950 chr17:5303493 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs858239 0.539 rs10280815 chr7:23188370 A/C cg23682824 chr7:23144976 KLHL7 0.51 6.83 0.39 5.81e-11 Cerebrospinal fluid biomarker levels; CESC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.26 0.36 1.51e-9 Cystic fibrosis severity; CESC cis rs9457247 0.602 rs10484530 chr6:167461562 C/T cg07741184 chr6:167504864 NA 0.37 6.49 0.37 4.2e-10 Crohn's disease; CESC cis rs559928 0.606 rs60394481 chr11:63909035 G/A cg18225595 chr11:63971243 STIP1 0.64 5.82 0.34 1.73e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs7223966 1.000 rs8077265 chr17:61732727 A/G cg11494091 chr17:61959527 GH2 0.38 5.42 0.32 1.34e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6582630 0.502 rs10880388 chr12:38401341 A/T cg13010199 chr12:38710504 ALG10B 0.48 6.21 0.36 2.03e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs10823500 0.777 rs7919014 chr10:71944577 T/C cg02100629 chr10:71892760 AIFM2 -0.34 -5.24 -0.31 3.33e-7 Blood protein levels; CESC cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg05347473 chr6:146136440 FBXO30 -0.7 -8.98 -0.48 5.21e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs909002 0.849 rs10798881 chr1:32101775 G/C cg13919466 chr1:32135498 COL16A1 -0.47 -8.09 -0.44 2.22e-14 Intelligence (multi-trait analysis); CESC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg18230493 chr5:56204884 C5orf35 -0.81 -9.36 -0.5 3.64e-18 Initial pursuit acceleration; CESC cis rs2243480 0.831 rs7806717 chr7:65393174 A/G cg25894440 chr7:65020034 NA 0.59 5.07 0.3 7.57e-7 Diabetic kidney disease; CESC cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.03 0.35 5.45e-9 Colorectal cancer; CESC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg06481639 chr22:41940642 POLR3H -0.62 -6.52 -0.37 3.5e-10 Vitiligo; CESC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg08499158 chr17:42289980 UBTF -0.46 -5.66 -0.33 4e-8 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02445447 chr2:106015594 FHL2 0.59 7.22 0.41 5.41e-12 Gut microbiome composition (summer); CESC cis rs2439831 1.000 rs9920763 chr15:43760508 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.73 5.85 0.34 1.42e-8 Lung cancer in ever smokers; CESC trans rs875971 0.660 rs6460308 chr7:66084740 T/C cg26939375 chr7:64535504 NA -0.64 -8.62 -0.47 6.36e-16 Aortic root size; CESC cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg16339924 chr4:17578868 LAP3 0.67 8.66 0.47 4.55e-16 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3733585 0.781 rs57250714 chr4:9984529 C/T cg02734326 chr4:10020555 SLC2A9 0.44 6.19 0.36 2.22e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9487051 0.773 rs421790 chr6:109543428 T/A cg01475377 chr6:109611718 NA -0.37 -5.35 -0.31 1.92e-7 Reticulocyte fraction of red cells; CESC cis rs6496667 1.000 rs16944254 chr15:90898527 C/T cg22089800 chr15:90895588 ZNF774 0.57 5.76 0.33 2.27e-8 Rheumatoid arthritis; CESC cis rs921968 0.521 rs56923478 chr2:219638539 A/G cg02176678 chr2:219576539 TTLL4 -0.43 -7.66 -0.43 3.42e-13 Mean corpuscular hemoglobin concentration; CESC cis rs9660992 0.548 rs1172152 chr1:205220718 T/A cg21643547 chr1:205240462 TMCC2 -0.41 -5.72 -0.33 2.88e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs6088590 0.965 rs13040449 chr20:33358901 T/A cg24642439 chr20:33292090 TP53INP2 0.85 11.66 0.58 1.21e-25 Coronary artery disease; CESC cis rs11723261 0.582 rs114199753 chr4:163520 G/C cg12746427 chr4:53362 ZNF718;ZNF595 0.45 5.66 0.33 3.9e-8 Immune response to smallpox vaccine (IL-6); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22273042 chr8:81083829 TPD52 0.55 6.52 0.37 3.48e-10 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg18099408 chr3:52552593 STAB1 -0.3 -5.11 -0.3 6.18e-7 Bipolar disorder; CESC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg11764359 chr7:65958608 NA -0.54 -7.04 -0.4 1.6e-11 Aortic root size; CESC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg08704250 chr15:31115839 NA -0.63 -8.17 -0.45 1.28e-14 Huntington's disease progression; CESC cis rs6696846 0.765 rs61822565 chr1:205077332 T/C cg00857998 chr1:205179979 DSTYK 0.55 7.28 0.41 3.77e-12 Red blood cell count; CESC cis rs17209837 0.607 rs2270187 chr7:87080698 T/C cg00919237 chr7:87102261 ABCB4 -0.51 -6.61 -0.38 2.1e-10 Gallbladder cancer; CESC cis rs10791097 0.667 rs12363163 chr11:130744509 A/G cg12179176 chr11:130786555 SNX19 0.64 9.86 0.52 9.69e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4604732 0.631 rs1106720 chr1:247624681 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs7385804 0.796 rs2432930 chr7:100299024 A/G cg20848291 chr7:100343083 ZAN 0.55 7.55 0.42 6.97e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs593982 0.688 rs3897552 chr11:65560880 C/T cg08755490 chr11:65554678 OVOL1 -1.24 -12.39 -0.61 4.22e-28 Atopic dermatitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22897130 chr10:89419623 PAPSS2 0.53 6.2 0.36 2.21e-9 Gut microbiome composition (summer); CESC cis rs1499614 1.000 rs2707830 chr7:66167645 T/C cg13147721 chr7:65941812 NA -0.94 -8.9 -0.48 9.08e-17 Gout; CESC cis rs741677 0.679 rs11655839 chr17:468945 G/C cg15660573 chr17:549704 VPS53 0.41 5.32 0.31 2.25e-7 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); CESC cis rs6732160 0.588 rs11126392 chr2:73374454 A/G cg01422370 chr2:73384389 NA 0.57 9.1 0.49 2.21e-17 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC trans rs9858542 0.953 rs11710037 chr3:49675334 C/G cg21659725 chr3:3221576 CRBN -0.52 -6.32 -0.36 1.13e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7089973 0.872 rs35010779 chr10:116631816 A/C cg23260525 chr10:116636907 FAM160B1 0.37 6.15 0.35 2.84e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs12042107 1.000 rs12042107 chr1:91196176 T/C cg13456504 chr1:91191583 NA 0.37 6.64 0.38 1.81e-10 Educational attainment; CESC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg07701084 chr6:150067640 NUP43 0.47 6.67 0.38 1.46e-10 Lung cancer; CESC cis rs208520 0.661 rs7740835 chr6:66865548 G/A cg07460842 chr6:66804631 NA -1.0 -13.46 -0.64 7.8e-32 Exhaled nitric oxide output; CESC cis rs2108225 0.837 rs6466186 chr7:107446966 G/C cg18560240 chr7:107437656 SLC26A3 -0.38 -5.26 -0.31 2.92e-7 Ulcerative colitis; CESC cis rs116095464 0.558 rs56043030 chr5:220917 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.74 0.33 2.63e-8 Breast cancer; CESC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg08736216 chr1:53307985 ZYG11A 0.32 5.74 0.33 2.59e-8 Monocyte count; CESC cis rs12681288 0.676 rs2701910 chr8:1001246 G/T cg15309053 chr8:964076 NA 0.38 6.47 0.37 4.6e-10 Schizophrenia; CESC cis rs698833 0.926 rs1067353 chr2:44666626 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.88 0.34 1.26e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs12325245 0.536 rs71375919 chr16:58547522 C/T cg27113419 chr16:58533979 NDRG4 -0.66 -5.08 -0.3 7.04e-7 Schizophrenia; CESC cis rs910316 1.000 rs12889309 chr14:75593902 C/T cg11812906 chr14:75593930 NEK9 0.91 15.82 0.7 3.78e-40 Height; CESC cis rs2637266 0.934 rs2395408 chr10:78380929 G/A cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC cis rs5167 0.504 rs8100120 chr19:45466058 T/C cg13119609 chr19:45449297 APOC2 0.46 7.39 0.41 1.94e-12 Blood protein levels; CESC cis rs11650494 0.908 rs11658111 chr17:47383994 C/T cg08112188 chr17:47440006 ZNF652 0.94 6.74 0.38 1.01e-10 Prostate cancer; CESC cis rs1215050 0.791 rs165254 chr4:98763564 C/T cg05340658 chr4:99064831 C4orf37 0.51 6.65 0.38 1.63e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg26314531 chr2:26401878 FAM59B 0.81 8.1 0.45 2.06e-14 Gut microbiome composition (summer); CESC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg13577194 chr9:95378173 IPPK 0.44 6.12 0.35 3.38e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26459114 chr12:124827635 NCOR2 -0.54 -6.13 -0.35 3.25e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg06634786 chr22:41940651 POLR3H -0.73 -7.69 -0.43 2.96e-13 Vitiligo; CESC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg07677032 chr17:61819896 STRADA -0.44 -5.49 -0.32 9.22e-8 Height; CESC cis rs11098499 0.909 rs10014719 chr4:120320715 G/A cg24375607 chr4:120327624 NA 0.48 5.87 0.34 1.28e-8 Corneal astigmatism; CESC cis rs9814567 1.000 rs11927068 chr3:134266321 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg24675658 chr1:53192096 ZYG11B 0.64 7.91 0.44 6.88e-14 Monocyte count; CESC cis rs4948102 0.653 rs6593294 chr7:56063201 G/C cg09872392 chr7:56161020 PHKG1 -0.46 -7.13 -0.4 9.47e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs7267979 0.657 rs6107073 chr20:25716363 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.71 11.43 0.57 7.05e-25 Liver enzyme levels (alkaline phosphatase); CESC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg07701084 chr6:150067640 NUP43 -0.43 -5.88 -0.34 1.26e-8 Lung cancer; CESC trans rs853679 0.546 rs200981 chr6:27833174 A/G cg06606381 chr12:133084897 FBRSL1 -0.79 -7.5 -0.42 9.37e-13 Depression; CESC cis rs2816062 0.786 rs2816059 chr1:18902977 G/A cg18795169 chr1:18902165 NA -0.93 -18.04 -0.74 5.04e-48 Urate levels in lean individuals; CESC cis rs7582720 0.945 rs116773016 chr2:203811902 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs17376456 0.825 rs10072232 chr5:93398890 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.03 0.3 9.15e-7 Diabetic retinopathy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23506944 chr17:28257236 EFCAB5;SSH2 0.46 6.54 0.37 3.21e-10 Gut microbiota (bacterial taxa); CESC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg12463550 chr7:65579703 CRCP -0.53 -6.61 -0.38 2.05e-10 Aortic root size; CESC cis rs9929218 0.953 rs9939049 chr16:68812301 A/T cg02972257 chr16:68554789 NA 0.43 5.14 0.3 5.28e-7 Colorectal cancer; CESC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg08736216 chr1:53307985 ZYG11A -0.36 -6.07 -0.35 4.31e-9 Monocyte count; CESC cis rs9302635 0.513 rs13334151 chr16:72189727 A/C cg16558253 chr16:72132732 DHX38 -0.43 -5.34 -0.31 2.03e-7 Blood protein levels; CESC cis rs7937682 0.883 rs529529 chr11:111461128 C/T cg09085632 chr11:111637200 PPP2R1B -0.9 -12.8 -0.62 1.63e-29 Primary sclerosing cholangitis; CESC cis rs1003719 0.788 rs4817843 chr21:38447040 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.7 0.47 3.48e-16 Eye color traits; CESC cis rs2836633 0.895 rs62217513 chr21:40024416 A/T cg05519781 chr21:40033154 ERG 0.79 13.36 0.63 1.84e-31 Coronary artery disease; CESC cis rs4074961 0.544 rs11264067 chr1:37991458 C/T cg13401533 chr1:37979913 MEAF6 0.6 8.22 0.45 8.88e-15 Axial length; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg16418817 chr21:40198485 NA 0.44 6.46 0.37 4.9e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9911578 1.000 rs304299 chr17:56838472 C/G cg05425664 chr17:57184151 TRIM37 -0.48 -6.72 -0.38 1.12e-10 Intelligence (multi-trait analysis); CESC cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg02297831 chr4:17616191 MED28 0.51 6.18 0.35 2.44e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11098499 0.863 rs10034450 chr4:120455649 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.47e-19 Corneal astigmatism; CESC trans rs7943203 0.962 rs2118308 chr11:108315463 C/G cg24643211 chr18:11851603 GNAL;CHMP1B -0.47 -6.14 -0.35 3.07e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg25985355 chr7:65971099 NA 0.32 5.23 0.31 3.53e-7 Aortic root size; CESC cis rs9303401 1.000 rs1390006 chr17:56890663 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.74 -9.48 -0.5 1.49e-18 Cognitive test performance; CESC cis rs8017423 0.967 rs60548738 chr14:90724399 G/A cg14092571 chr14:90743983 NA -0.55 -8.33 -0.46 4.28e-15 Mortality in heart failure; CESC cis rs10276381 1.000 rs10276381 chr7:28190121 A/G cg23620719 chr7:28220237 JAZF1 -0.75 -7.76 -0.43 1.89e-13 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26389465 chr11:112097071 PTS 0.49 6.2 0.36 2.2e-9 Gut microbiome composition (summer); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg26959303 chr3:133375668 TOPBP1 0.38 6.38 0.36 8.01e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2985684 1.000 rs3007030 chr14:50086563 C/T cg02151108 chr14:50098012 C14orf104 -0.47 -6.1 -0.35 3.83e-9 Carotid intima media thickness; CESC cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg10523679 chr1:76189770 ACADM 0.65 6.12 0.35 3.39e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9926296 0.572 rs2079671 chr16:89884981 T/C cg07648498 chr16:89883185 FANCA 0.42 5.03 0.3 8.92e-7 Vitiligo; CESC cis rs8014204 0.762 rs7144654 chr14:75298637 A/G cg08847533 chr14:75593920 NEK9 0.43 5.6 0.33 5.27e-8 Caffeine consumption; CESC cis rs7223966 1.000 rs12325866 chr17:61755974 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.16 -0.3 4.73e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg05347473 chr6:146136440 FBXO30 -0.58 -6.93 -0.39 3.21e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9287719 0.934 rs6727884 chr2:10757557 C/T cg00105475 chr2:10696890 NA -0.38 -5.54 -0.32 7.18e-8 Prostate cancer; CESC cis rs2273669 0.667 rs76430494 chr6:109350128 C/A cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.37e-9 Prostate cancer; CESC cis rs116095464 0.558 rs10059907 chr5:205360 G/C cg22496380 chr5:211416 CCDC127 -0.95 -10.05 -0.53 2.34e-20 Breast cancer; CESC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs6582630 0.519 rs4002438 chr12:38484880 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.39 0.54 1.95e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs6460942 0.556 rs10228123 chr7:12374025 A/C cg20607287 chr7:12443886 VWDE -0.53 -7.64 -0.43 3.86e-13 Coronary artery disease; CESC cis rs2380220 0.606 rs4571572 chr6:96004823 T/C cg04719120 chr6:96025338 MANEA 0.46 5.26 0.31 2.97e-7 Behavioural disinhibition (generation interaction); CESC cis rs9611519 0.929 rs9611509 chr22:41565827 A/G cg03806693 chr22:41940476 POLR3H -0.56 -5.76 -0.33 2.28e-8 Neuroticism; CESC cis rs6831352 0.840 rs29001223 chr4:100047433 C/T cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs17253792 0.908 rs9972177 chr14:56073206 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.98 0.34 7.23e-9 Putamen volume; CESC cis rs4835473 0.900 rs4835449 chr4:144879983 C/G cg25736465 chr4:144833511 NA 0.41 6.11 0.35 3.59e-9 Immature fraction of reticulocytes; CESC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.06 0.3 7.92e-7 Menopause (age at onset); CESC cis rs425277 0.958 rs262639 chr1:2107061 G/T cg16545954 chr1:2118288 C1orf86 0.32 5.48 0.32 9.85e-8 Height; CESC cis rs7188697 0.883 rs4485352 chr16:58601410 A/G cg21335942 chr16:58549945 SETD6 -0.45 -5.24 -0.31 3.34e-7 QT interval; CESC cis rs7520050 0.966 rs6672898 chr1:46290588 G/A cg24296786 chr1:45957014 TESK2 0.43 5.42 0.32 1.32e-7 Red blood cell count;Reticulocyte count; CESC trans rs6137287 0.924 rs6047279 chr20:21142353 C/T cg03786336 chr3:193854201 HES1 -0.4 -6.01 -0.35 6.07e-9 Height; CESC cis rs1348850 0.914 rs12693120 chr2:178283288 A/G cg23306229 chr2:178417860 TTC30B 0.65 8.48 0.46 1.56e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg18099408 chr3:52552593 STAB1 -0.38 -6.47 -0.37 4.69e-10 Electroencephalogram traits; CESC cis rs7927771 1.000 rs12363232 chr11:47623890 C/T cg05585544 chr11:47624801 NA -0.53 -8.2 -0.45 1.05e-14 Subjective well-being; CESC cis rs60154123 0.730 rs652241 chr1:210465029 A/T cg21951975 chr1:209979733 IRF6 0.45 6.15 0.35 2.92e-9 Coronary artery disease; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg23375431 chr12:122242145 LOC338799;SETD1B 0.49 6.02 0.35 5.92e-9 Psoriatic arthritis; CESC cis rs2243480 1.000 rs313824 chr7:65581207 C/T cg18252515 chr7:66147081 NA -1.39 -13.92 -0.65 1.93e-33 Diabetic kidney disease; CESC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9905704 0.918 rs12949138 chr17:56934865 A/C cg12560992 chr17:57184187 TRIM37 0.6 7.0 0.39 2.11e-11 Testicular germ cell tumor; CESC cis rs5758511 0.680 rs5758662 chr22:42628088 T/C cg00645731 chr22:42541494 CYP2D7P1 0.58 8.64 0.47 5.43e-16 Birth weight; CESC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg23172400 chr8:95962367 TP53INP1 -0.47 -9.9 -0.52 7.45e-20 Type 2 diabetes; CESC cis rs7264396 0.561 rs6058388 chr20:34571846 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.49 5.65 0.33 4.21e-8 Total cholesterol levels; CESC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg12373951 chr3:133503437 NA 0.49 6.88 0.39 4.21e-11 Iron status biomarkers; CESC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg18402987 chr7:1209562 NA 0.62 7.24 0.41 4.95e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7223966 1.000 rs7211213 chr17:61769456 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.94 0.39 3.1e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg18904891 chr8:8559673 CLDN23 0.72 8.03 0.44 3.21e-14 Obesity-related traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09992653 chr13:53226650 SUGT1 -0.46 -6.48 -0.37 4.43e-10 Gut microbiota (bacterial taxa); CESC cis rs7264396 0.790 rs2207889 chr20:34224898 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 3.02e-26 Total cholesterol levels; CESC cis rs10242455 0.557 rs73403272 chr7:99134208 T/G cg25640893 chr7:99214727 ZNF498 0.76 5.91 0.34 1.05e-8 Blood metabolite levels; CESC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.1 0.4 1.14e-11 Tonsillectomy; CESC cis rs2297440 0.506 rs2236504 chr20:62224762 C/T cg09650180 chr20:62225654 GMEB2 -0.82 -9.28 -0.5 6.11e-18 Glioma;Non-glioblastoma glioma;Glioblastoma; CESC cis rs858239 0.896 rs1637193 chr7:23260251 G/T cg23682824 chr7:23144976 KLHL7 0.48 6.54 0.37 3.12e-10 Cerebrospinal fluid biomarker levels; CESC cis rs4629180 0.538 rs6746761 chr2:102122390 G/T cg04415270 chr2:102091202 RFX8 -0.32 -5.5 -0.32 9.09e-8 Chronic rhinosinusitis with nasal polyps; CESC cis rs3008870 1.000 rs2815348 chr1:67472165 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.03 14.0 0.65 1e-33 Lymphocyte percentage of white cells; CESC cis rs2953145 0.568 rs1133352 chr2:241522252 A/G cg07929629 chr2:241523174 NA -0.55 -6.89 -0.39 3.99e-11 Bipolar disorder; CESC cis rs698833 0.892 rs786408 chr2:44733156 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.52 6.37 0.36 8.3e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs9346455 0.614 rs9360445 chr6:72000866 G/T cg27238071 chr6:71998145 OGFRL1 0.63 6.1 0.35 3.76e-9 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs7208859 0.673 rs450585 chr17:28951039 G/A cg19761014 chr17:28927070 LRRC37B2 0.79 7.38 0.41 2.05e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg15112475 chr7:1198522 ZFAND2A -0.39 -6.1 -0.35 3.65e-9 Longevity;Endometriosis; CESC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg22535103 chr8:58192502 C8orf71 -0.75 -8.89 -0.48 9.37e-17 Developmental language disorder (linguistic errors); CESC cis rs601339 1.000 rs4759361 chr12:123178280 T/A cg11919336 chr12:123188078 GPR109A 0.46 5.93 0.34 9.17e-9 Adiponectin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09260603 chr1:206809102 DYRK3 0.62 7.01 0.4 2.02e-11 Gut microbiome composition (summer); CESC cis rs36051895 0.622 rs10815143 chr9:5009541 G/A cg02405213 chr9:5042618 JAK2 -0.48 -5.8 -0.34 1.89e-8 Pediatric autoimmune diseases; CESC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg22535103 chr8:58192502 C8orf71 -0.81 -8.91 -0.48 8.46e-17 Developmental language disorder (linguistic errors); CESC cis rs734999 0.545 rs6666788 chr1:2567500 A/G cg20673091 chr1:2541236 MMEL1 -0.48 -8.1 -0.45 2.01e-14 Ulcerative colitis; CESC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg00149659 chr3:10157352 C3orf10 0.73 8.83 0.48 1.44e-16 Alzheimer's disease; CESC cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 4.04e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8062405 0.721 rs151303 chr16:28492510 C/A cg08761264 chr16:28874980 SH2B1 -0.45 -5.29 -0.31 2.5e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs854765 0.583 rs4341796 chr17:17839024 C/A cg09796270 chr17:17721594 SREBF1 0.47 6.52 0.37 3.49e-10 Total body bone mineral density; CESC cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.95 0.34 8.45e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.87 9.17 0.49 1.38e-17 Platelet count; CESC cis rs1670533 1.000 rs7669399 chr4:1058478 T/G cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.7e-7 Recombination rate (females); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06197760 chr6:7585736 DSP 0.44 6.03 0.35 5.42e-9 Fibrinogen levels; CESC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg03806693 chr22:41940476 POLR3H -1.14 -13.12 -0.63 1.26e-30 Crohn's disease;Inflammatory bowel disease; CESC trans rs9650657 0.538 rs11250093 chr8:10798828 C/T cg15556689 chr8:8085844 FLJ10661 0.53 6.41 0.37 6.64e-10 Neuroticism; CESC cis rs116095464 0.558 rs2288457 chr5:231270 C/T cg22857025 chr5:266934 NA -1.28 -18.2 -0.75 1.47e-48 Breast cancer; CESC cis rs78707713 0.592 rs3829182 chr10:71251384 A/G cg12610070 chr10:71211762 TSPAN15 -0.31 -6.47 -0.37 4.8e-10 Venous thromboembolism; CESC cis rs1691799 0.799 rs10784525 chr12:66772766 G/A cg16791601 chr12:66731901 HELB -0.59 -9.64 -0.51 4.7e-19 White blood cell count (basophil); CESC cis rs7605827 0.930 rs4668448 chr2:15521740 T/C cg19274914 chr2:15703543 NA 0.38 6.76 0.38 8.66e-11 Educational attainment (years of education); CESC cis rs7584330 0.868 rs2325839 chr2:238386286 T/C cg11271282 chr2:238384023 NA 0.48 5.49 0.32 9.18e-8 Prostate cancer; CESC cis rs992157 0.835 rs34353396 chr2:219153982 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.66 -8.75 -0.47 2.45e-16 Colorectal cancer; CESC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg00074818 chr8:8560427 CLDN23 -0.37 -5.38 -0.31 1.65e-7 Obesity-related traits; CESC cis rs2880765 0.743 rs8039049 chr15:86007629 A/G cg10818794 chr15:86012489 AKAP13 -0.33 -5.12 -0.3 6.02e-7 Coronary artery disease; CESC cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg14784868 chr12:69753453 YEATS4 0.92 14.62 0.67 6.85e-36 Cerebrospinal fluid biomarker levels; CESC cis rs2274273 0.905 rs28429419 chr14:55574793 T/C cg04306507 chr14:55594613 LGALS3 0.28 5.58 0.32 5.89e-8 Protein biomarker; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19882093 chr20:23969397 GGTLC1 0.38 6.07 0.35 4.37e-9 Ulcerative colitis; CESC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.4 0.37 6.85e-10 Menopause (age at onset); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg16522107 chr15:65579214 PARP16 0.5 6.46 0.37 5.11e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs28374715 0.532 rs28463309 chr15:41666716 A/G cg02330683 chr15:41787940 ITPKA 0.42 5.19 0.3 4.26e-7 Ulcerative colitis; CESC cis rs9902453 0.704 rs1972305 chr17:28533880 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 6.96 0.39 2.6e-11 Coffee consumption (cups per day); CESC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg12311346 chr5:56204834 C5orf35 -0.72 -8.82 -0.48 1.62e-16 Initial pursuit acceleration; CESC cis rs11715604 1 rs11715604 chr3:136589549 A/T cg15507776 chr3:136538369 TMEM22 -0.72 -7.14 -0.4 8.94e-12 B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy); CESC cis rs796364 0.755 rs203762 chr2:200905136 C/A cg23649088 chr2:200775458 C2orf69 -0.56 -5.08 -0.3 7.14e-7 Schizophrenia; CESC trans rs1814175 0.817 rs1988416 chr11:49932324 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -21.21 -0.79 4.77e-59 Height; CESC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg18252515 chr7:66147081 NA -0.47 -6.08 -0.35 4.25e-9 Aortic root size; CESC cis rs13392177 0.660 rs12988046 chr2:219073804 A/G cg00012203 chr2:219082015 ARPC2 -0.64 -7.88 -0.44 8.42e-14 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs7937682 0.855 rs571462 chr11:111487106 C/G cg09085632 chr11:111637200 PPP2R1B -0.95 -14.6 -0.67 8.26e-36 Primary sclerosing cholangitis; CESC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.52 -0.37 3.51e-10 Life satisfaction; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12583927 chr10:61469753 SLC16A9 -0.45 -6.03 -0.35 5.39e-9 Fibrinogen levels; CESC cis rs290268 0.647 rs1333637 chr9:93557066 C/T cg02608019 chr9:93564028 SYK -0.49 -6.86 -0.39 4.94e-11 Platelet count; CESC trans rs11992162 0.621 rs13268810 chr8:11797430 A/T cg15556689 chr8:8085844 FLJ10661 0.51 6.35 0.36 9.34e-10 Monocyte count; CESC cis rs61841072 0.961 rs7517403 chr1:243135892 C/T cg02356786 chr1:243265016 LOC731275 0.43 5.64 0.33 4.46e-8 Schizophrenia; CESC cis rs6714710 0.603 rs11684749 chr2:98420142 G/C cg26665480 chr2:98280029 ACTR1B 0.56 7.96 0.44 5.02e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs79349575 0.729 rs62075824 chr17:46986679 A/G cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg11764359 chr7:65958608 NA 0.7 9.17 0.49 1.39e-17 Aortic root size; CESC cis rs2637266 0.756 rs846607 chr10:78561254 A/T cg18941641 chr10:78392320 NA 0.41 7.8 0.43 1.42e-13 Pulmonary function; CESC trans rs6934970 0.789 rs6908498 chr6:112984103 G/A cg05146922 chr2:10634174 NA -0.37 -6.17 -0.35 2.53e-9 Bipolar disorder (body mass index interaction); CESC trans rs3780486 0.846 rs7873903 chr9:33142728 G/A cg04842962 chr6:43655489 MRPS18A 0.99 17.9 0.74 1.59e-47 IgG glycosylation; CESC cis rs7296418 0.922 rs1790134 chr12:123697898 T/C cg00376283 chr12:123451042 ABCB9 0.67 9.58 0.51 7.62e-19 Platelet count; CESC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg07677032 chr17:61819896 STRADA 0.44 5.88 0.34 1.21e-8 Prudent dietary pattern; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09369792 chr10:118886279 NA -0.39 -6.07 -0.35 4.34e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs208520 1.000 rs72884017 chr6:66992513 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.14 0.49 1.65e-17 Exhaled nitric oxide output; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19813935 chr1:153959405 RAB13 -0.43 -6.37 -0.36 8.35e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9902453 0.765 rs2729448 chr17:28091953 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.42 -0.54 1.51e-21 Coffee consumption (cups per day); CESC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 11.7 0.58 8.86e-26 Platelet count; CESC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg27588902 chr6:42928151 GNMT -0.28 -5.25 -0.31 3.17e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9902453 0.808 rs62068617 chr17:28144728 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.47 0.46 1.74e-15 Coffee consumption (cups per day); CESC cis rs5758659 0.652 rs133349 chr22:42428727 A/T cg19513890 chr22:42538836 CYP2D7P1 -0.39 -5.77 -0.33 2.27e-8 Cognitive function; CESC cis rs36051895 0.603 rs10974972 chr9:5130146 G/A cg02405213 chr9:5042618 JAK2 -0.5 -6.26 -0.36 1.55e-9 Pediatric autoimmune diseases; CESC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg06108461 chr20:60628389 TAF4 -0.92 -14.55 -0.67 1.22e-35 Body mass index; CESC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg17372223 chr3:52568218 NT5DC2 0.43 6.54 0.37 3.21e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21813591 chr1:147071537 BCL9 0.61 6.65 0.38 1.65e-10 Gut microbiome composition (summer); CESC trans rs453301 0.571 rs330048 chr8:9087278 A/C cg15556689 chr8:8085844 FLJ10661 -0.5 -6.31 -0.36 1.18e-9 Joint mobility (Beighton score); CESC cis rs7394190 0.748 rs3781216 chr10:75522404 G/A cg07699608 chr10:75541558 CHCHD1 0.6 5.08 0.3 7.13e-7 Incident atrial fibrillation; CESC cis rs4588572 0.606 rs4290994 chr5:77742253 C/T cg11547950 chr5:77652471 NA -0.4 -5.56 -0.32 6.42e-8 Triglycerides; CESC cis rs12541635 0.677 rs1496180 chr8:106973877 T/G cg10147462 chr8:107024639 NA 0.43 6.28 0.36 1.42e-9 Age of smoking initiation; CESC cis rs2228479 0.850 rs62054601 chr16:89811751 C/G cg06558623 chr16:89946397 TCF25 1.15 9.12 0.49 1.99e-17 Skin colour saturation; CESC cis rs1348850 0.874 rs13013752 chr2:178456862 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.32 0.46 4.74e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg06627628 chr2:24431161 ITSN2 -0.67 -6.33 -0.36 1.06e-9 Lymphocyte counts; CESC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg19468946 chr17:37922297 IKZF3 -0.4 -5.19 -0.3 4.22e-7 Glomerular filtration rate (creatinine); CESC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg05313129 chr8:58192883 C8orf71 -0.51 -5.07 -0.3 7.46e-7 Developmental language disorder (linguistic errors); CESC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg21433313 chr16:3507492 NAT15 0.52 8.59 0.47 7.52e-16 Tuberculosis; CESC cis rs1023500 0.573 rs133380 chr22:42468910 C/T cg04733989 chr22:42467013 NAGA 0.64 9.46 0.5 1.76e-18 Schizophrenia; CESC cis rs10752881 1.000 rs10752887 chr1:182990834 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.31 0.63 2.66e-31 Colorectal cancer; CESC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg09699651 chr6:150184138 LRP11 -0.44 -5.66 -0.33 3.96e-8 Lung cancer; CESC trans rs5758511 0.773 rs11913631 chr22:42347371 G/T cg15080870 chr19:47770746 CCDC9 0.49 6.15 0.35 2.86e-9 Birth weight; CESC cis rs2479106 0.791 rs57187369 chr9:126712127 C/A cg16191174 chr9:126692580 DENND1A 0.42 5.64 0.33 4.33e-8 Polycystic ovary syndrome; CESC cis rs3096299 0.967 rs2965937 chr16:89488779 A/T cg00750074 chr16:89608354 SPG7 -0.4 -5.77 -0.33 2.22e-8 Multiple myeloma (IgH translocation); CESC cis rs6831352 0.918 rs2851251 chr4:100044111 A/G cg13256891 chr4:100009986 ADH5 0.74 8.21 0.45 9.57e-15 Alcohol dependence; CESC cis rs3008870 0.651 rs2815376 chr1:67508531 G/A cg02640540 chr1:67518911 SLC35D1 0.63 8.35 0.46 3.76e-15 Lymphocyte percentage of white cells; CESC cis rs7520050 0.807 rs28647556 chr1:46206399 G/A cg06784218 chr1:46089804 CCDC17 0.32 5.84 0.34 1.55e-8 Red blood cell count;Reticulocyte count; CESC cis rs16866061 1.000 rs7588380 chr2:225341304 A/T cg12698349 chr2:225449008 CUL3 -0.73 -10.68 -0.55 2.29e-22 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs9467711 0.606 rs66827971 chr6:26365766 T/C cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.59e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9814567 1.000 rs7427492 chr3:134261654 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.37 -0.36 8.41e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs10463316 0.817 rs6880228 chr5:150778145 A/T cg03212797 chr5:150827313 SLC36A1 0.4 5.16 0.3 4.86e-7 Metabolite levels (Pyroglutamine); CESC trans rs12310956 0.532 rs10506119 chr12:33963684 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.35 0.46 3.79e-15 Morning vs. evening chronotype; CESC cis rs11630290 0.592 rs8028348 chr15:64156465 A/G cg12036633 chr15:63758958 NA 0.43 5.31 0.31 2.36e-7 Iris characteristics; CESC trans rs10463316 0.855 rs13359064 chr5:150765575 G/A cg24389359 chr12:111284228 CCDC63 -0.34 -6.2 -0.36 2.19e-9 Metabolite levels (Pyroglutamine); CESC cis rs12893597 0.715 rs74639969 chr14:76832150 A/G cg20290672 chr14:76816747 NA -0.4 -5.62 -0.33 4.95e-8 Maximal oxygen uptake response; CESC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg18337363 chr3:52569053 NT5DC2 0.29 5.27 0.31 2.85e-7 Bipolar disorder; CESC cis rs709400 0.663 rs7145113 chr14:103945414 A/G cg12935359 chr14:103987150 CKB -0.54 -7.98 -0.44 4.4e-14 Body mass index; CESC cis rs9486715 0.867 rs211159 chr6:97023026 G/A cg18709589 chr6:96969512 KIAA0776 -0.46 -6.58 -0.37 2.52e-10 Headache; CESC cis rs4253772 0.938 rs41355347 chr22:46637511 G/A cg18190219 chr22:46762943 CELSR1 -0.61 -5.84 -0.34 1.52e-8 LDL cholesterol;Cholesterol, total; CESC cis rs6088580 0.634 rs6059829 chr20:33017074 G/A cg08999081 chr20:33150536 PIGU 0.65 11.36 0.57 1.22e-24 Glomerular filtration rate (creatinine); CESC cis rs37004 0.748 rs380145 chr5:1328897 C/T cg06550200 chr5:1325588 CLPTM1L -0.6 -5.9 -0.34 1.1e-8 Prostate-specific antigen levels; CESC cis rs1707322 1.000 rs785504 chr1:46595696 C/T cg03146154 chr1:46216737 IPP -0.69 -9.04 -0.49 3.51e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg07507251 chr3:52567010 NT5DC2 0.32 5.57 0.32 6.41e-8 Bipolar disorder; CESC cis rs3768617 0.510 rs20558 chr1:183094547 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs7824557 0.545 rs2736303 chr8:11236850 C/T cg21775007 chr8:11205619 TDH -0.54 -8.05 -0.44 2.77e-14 Retinal vascular caliber; CESC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg07648498 chr16:89883185 FANCA 0.45 5.48 0.32 9.69e-8 Vitiligo; CESC cis rs4911259 0.552 rs13038017 chr20:31467551 T/C cg13636640 chr20:31349939 DNMT3B -0.54 -7.44 -0.42 1.45e-12 Inflammatory bowel disease; CESC cis rs4253772 0.591 rs6008384 chr22:46655948 T/C cg24881330 chr22:46731750 TRMU 0.89 10.11 0.53 1.55e-20 LDL cholesterol;Cholesterol, total; CESC cis rs734999 0.588 rs2843404 chr1:2530558 T/C cg20673091 chr1:2541236 MMEL1 -0.44 -7.2 -0.4 6.32e-12 Ulcerative colitis; CESC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg11764359 chr7:65958608 NA -0.78 -11.43 -0.57 7.29e-25 Aortic root size; CESC cis rs6662572 1.000 rs3014232 chr1:46131873 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 5.64 0.33 4.28e-8 Blood protein levels; CESC cis rs1046896 0.731 rs8067667 chr17:80785875 A/G cg19500275 chr17:80737654 TBCD 0.5 5.57 0.32 6.15e-8 Glycated hemoglobin levels; CESC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.64 8.62 0.47 6.34e-16 Total body bone mineral density; CESC cis rs7267979 0.780 rs6050679 chr20:25537827 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.69 11.99 0.59 9.5e-27 Liver enzyme levels (alkaline phosphatase); CESC cis rs7017914 0.967 rs13258584 chr8:71671579 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs2243480 0.711 rs2420172 chr7:65635341 T/C cg13147721 chr7:65941812 NA 0.97 9.19 0.49 1.2e-17 Diabetic kidney disease; CESC cis rs9815354 0.767 rs60764195 chr3:41812522 G/C cg03022575 chr3:42003672 ULK4 0.7 6.14 0.35 2.98e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg12365402 chr11:9010492 NRIP3 -0.46 -7.82 -0.43 1.23e-13 Hemoglobin concentration; CESC cis rs12579753 0.833 rs12579530 chr12:82163930 A/C cg21193143 chr12:82153300 PPFIA2 -0.35 -5.18 -0.3 4.31e-7 Resting heart rate; CESC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg18876405 chr7:65276391 NA -0.42 -5.57 -0.32 6.38e-8 Calcium levels; CESC cis rs2295499 0.873 rs4690085 chr4:2697300 A/G cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.33 -0.31 2.06e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs2243480 1.000 rs13237037 chr7:65997882 T/C cg13147721 chr7:65941812 NA -0.95 -8.91 -0.48 8.34e-17 Diabetic kidney disease; CESC cis rs42648 0.869 rs1015403 chr7:89913702 A/G cg23697855 chr7:89950296 NA 0.27 5.05 0.3 8.24e-7 Homocysteine levels; CESC cis rs9660992 0.626 rs61823972 chr1:205201325 A/C cg21643547 chr1:205240462 TMCC2 -0.38 -5.59 -0.32 5.74e-8 Mean corpuscular volume;Mean platelet volume; CESC trans rs11073464 1.000 rs11852643 chr15:96674664 T/C cg20048050 chr7:75911126 SRRM3 -0.49 -6.01 -0.35 5.96e-9 Facial morphology (factor 1, breadth of lateral portion of upper face); CESC cis rs7666738 0.830 rs13121766 chr4:98935766 A/C cg05340658 chr4:99064831 C4orf37 0.79 11.72 0.58 7.71e-26 Colonoscopy-negative controls vs population controls; CESC cis rs7264396 0.836 rs41293080 chr20:34187697 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -7.1 -0.4 1.15e-11 Total cholesterol levels; CESC cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg27297192 chr10:134578999 INPP5A 0.38 5.18 0.3 4.41e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7267979 1.000 rs6115191 chr20:25440478 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 15.81 0.7 4.28e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs3820928 0.874 rs12105952 chr2:227864521 G/A cg11843606 chr2:227700838 RHBDD1 -0.46 -5.92 -0.34 9.69e-9 Pulmonary function; CESC cis rs17376456 0.877 rs7734897 chr5:93305402 G/A cg21475434 chr5:93447410 FAM172A 0.75 6.78 0.38 7.96e-11 Diabetic retinopathy; CESC cis rs16910800 0.731 rs7125729 chr11:23181637 A/G cg20040320 chr11:23191996 NA -0.67 -6.66 -0.38 1.53e-10 Cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08007990 chr2:231276624 NA -0.45 -6.02 -0.35 5.73e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg21963583 chr11:68658836 MRPL21 -0.41 -5.71 -0.33 3.04e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21515243 chr18:21033072 RIOK3 0.48 6.41 0.37 6.75e-10 Gut microbiota (bacterial taxa); CESC cis rs4076764 0.801 rs6675964 chr1:163375960 A/G cg06092702 chr1:163392909 NA -0.39 -5.58 -0.32 6.08e-8 Motion sickness; CESC cis rs9467711 0.659 rs13195509 chr6:26463660 C/T cg14345882 chr6:26364793 BTN3A2 0.63 5.84 0.34 1.56e-8 Autism spectrum disorder or schizophrenia; CESC cis rs400736 0.602 rs4601608 chr1:8168808 A/G cg25007680 chr1:8021821 PARK7 -0.57 -7.67 -0.43 3.36e-13 Response to antidepressants and depression; CESC cis rs1538970 0.924 rs7531253 chr1:45890183 T/C cg24296786 chr1:45957014 TESK2 -0.46 -5.3 -0.31 2.41e-7 Platelet count; CESC cis rs3096299 0.967 rs28644774 chr16:89472181 G/C cg08822215 chr16:89438651 ANKRD11 -0.41 -6.45 -0.37 5.2400000000000005e-10 Multiple myeloma (IgH translocation); CESC cis rs9583531 0.689 rs9521913 chr13:111382058 C/T cg24331049 chr13:111365604 ING1 -0.71 -10.02 -0.52 2.95e-20 Coronary artery disease; CESC cis rs6582630 0.519 rs11181294 chr12:38312787 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs4253772 1.000 rs4253766 chr22:46623905 C/T cg18190219 chr22:46762943 CELSR1 -0.62 -6.69 -0.38 1.3e-10 LDL cholesterol;Cholesterol, total; CESC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg26335602 chr6:28129616 ZNF389 0.52 6.84 0.39 5.58e-11 Depression; CESC cis rs3796619 1.000 rs12647929 chr4:1092019 G/T cg27284194 chr4:1044797 NA 0.37 5.56 0.32 6.64e-8 Recombination rate (males); CESC cis rs7818345 0.967 rs4546679 chr8:19283335 C/A cg11303988 chr8:19266685 CSGALNACT1 0.35 6.42 0.37 6.42e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs1062177 0.906 rs2964573 chr5:151160122 A/T cg12924095 chr5:151150029 G3BP1 0.5 6.47 0.37 4.81e-10 Preschool internalizing problems; CESC cis rs10791323 0.660 rs2156681 chr11:133731644 G/T cg15485101 chr11:133734466 NA 0.38 6.48 0.37 4.51e-10 Childhood ear infection; CESC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg15445000 chr17:37608096 MED1 0.4 6.37 0.36 8.09e-10 Glomerular filtration rate (creatinine); CESC cis rs62229266 0.771 rs7277791 chr21:37383227 C/A cg12218747 chr21:37451666 NA -0.39 -5.48 -0.32 9.87e-8 Mitral valve prolapse; CESC cis rs36051895 0.659 rs10121491 chr9:5046935 T/C cg02405213 chr9:5042618 JAK2 -0.42 -5.23 -0.31 3.42e-7 Pediatric autoimmune diseases; CESC cis rs2880765 0.835 rs11074276 chr15:86030363 C/A cg10818794 chr15:86012489 AKAP13 -0.35 -5.39 -0.31 1.6e-7 Coronary artery disease; CESC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 10.43 0.54 1.4e-21 Platelet count; CESC cis rs733592 0.507 rs3825403 chr12:48457159 G/A cg04545296 chr12:48745243 ZNF641 -0.29 -5.34 -0.31 2e-7 Plateletcrit; CESC cis rs2637266 0.749 rs4979830 chr10:78457484 C/T cg18941641 chr10:78392320 NA 0.4 7.33 0.41 2.74e-12 Pulmonary function; CESC cis rs11122272 0.668 rs2790874 chr1:231537988 A/G cg06096015 chr1:231504339 EGLN1 0.42 6.05 0.35 4.97e-9 Hemoglobin concentration; CESC cis rs4589502 1.000 rs4589502 chr15:67155069 C/T cg12317470 chr15:67143691 NA 0.68 6.61 0.38 2.07e-10 Lung cancer (smoking interaction); CESC cis rs763121 0.853 rs5995610 chr22:39064681 C/T cg06544989 chr22:39130855 UNC84B 0.48 8.4 0.46 2.69e-15 Menopause (age at onset); CESC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.19 0.4 6.71e-12 Height; CESC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg02725872 chr8:58115012 NA -0.45 -6.94 -0.39 2.93e-11 Developmental language disorder (linguistic errors); CESC cis rs8070128 0.534 rs2955350 chr17:17953548 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.33 -0.36 1.03e-9 Total body bone mineral density; CESC cis rs9914988 0.943 rs9893782 chr17:27108132 C/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs763121 0.785 rs5757199 chr22:39040617 T/G cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs3105593 0.932 rs2414073 chr15:50850558 A/C cg08437265 chr15:50716283 USP8 0.41 5.29 0.31 2.54e-7 QT interval; CESC cis rs9818941 0.826 rs11714264 chr3:157655018 A/G cg08654915 chr3:157813417 NA 0.49 7.89 0.44 8.07e-14 Height; CESC cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg12927641 chr6:109611667 NA -0.43 -6.54 -0.37 3.2e-10 Reticulocyte fraction of red cells; CESC cis rs12931792 0.682 rs12373113 chr16:30187513 C/T cg17640201 chr16:30407289 ZNF48 0.6 8.24 0.45 8.18e-15 Tonsillectomy; CESC cis rs12545109 1.000 rs12545109 chr8:57313906 A/C cg09654669 chr8:57350985 NA -0.57 -7.51 -0.42 9.32e-13 Obesity-related traits; CESC cis rs11690935 0.959 rs76324055 chr2:172620150 T/A cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.87 -0.67 9.1e-37 Schizophrenia; CESC cis rs9911578 0.935 rs420878 chr17:56709077 A/G cg12560992 chr17:57184187 TRIM37 0.93 15.62 0.69 1.99e-39 Intelligence (multi-trait analysis); CESC cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg21918786 chr6:109611834 NA -0.4 -6.03 -0.35 5.44e-9 Reticulocyte fraction of red cells; CESC cis rs9929218 1.000 rs35069703 chr16:68789445 G/A cg02972257 chr16:68554789 NA 0.53 5.97 0.34 7.54e-9 Colorectal cancer; CESC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.09 0.6 4.37e-27 Alzheimer's disease; CESC cis rs4820539 1.000 rs4822362 chr22:23482744 C/A cg14186256 chr22:23484241 RTDR1 0.83 15.2 0.68 5.99e-38 Bone mineral density; CESC cis rs1865721 0.682 rs3745081 chr18:73142923 A/G cg26385618 chr18:73139727 C18orf62 -0.48 -7.77 -0.43 1.71e-13 Intelligence; CESC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg05872129 chr22:39784769 NA -0.72 -10.51 -0.54 7.81e-22 Intelligence (multi-trait analysis); CESC trans rs970548 0.738 rs61854113 chr10:46004815 C/T cg16175941 chr6:154779103 CNKSR3 0.56 6.44 0.37 5.66e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CESC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Parkinson's disease; CESC cis rs11098499 0.954 rs11935596 chr4:120412457 G/C cg09307838 chr4:120376055 NA 0.92 12.96 0.62 4.27e-30 Corneal astigmatism; CESC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.79 0.33 2.03e-8 Menopause (age at onset); CESC cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.55 5.5 0.32 8.85e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs826838 0.967 rs11169387 chr12:39145737 C/T cg26384229 chr12:38710491 ALG10B 0.79 13.34 0.63 2.07e-31 Heart rate; CESC cis rs6426558 0.537 rs2102634 chr1:227324308 T/C cg10327440 chr1:227177885 CDC42BPA -0.47 -5.9 -0.34 1.13e-8 Neutrophil percentage of white cells; CESC cis rs4409675 0.576 rs3766396 chr1:28221554 C/T cg23691781 chr1:28212827 C1orf38 -0.28 -5.3 -0.31 2.46e-7 Corneal astigmatism; CESC cis rs57244997 0.582 rs73030429 chr6:162438902 A/G cg17173639 chr6:162384350 PARK2 -0.45 -5.15 -0.3 5.19e-7 Mosquito bite size; CESC cis rs8072100 0.738 rs9895509 chr17:45549618 A/T cg25173405 chr17:45401733 C17orf57 0.42 5.35 0.31 1.92e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg24818145 chr4:99064322 C4orf37 0.38 5.05 0.3 8.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs425277 1.000 rs12401379 chr1:2058580 G/C cg16545954 chr1:2118288 C1orf86 0.34 5.65 0.33 4.17e-8 Height; CESC cis rs7818688 1.000 rs10093594 chr8:96033236 A/G cg16049864 chr8:95962084 TP53INP1 -0.58 -5.57 -0.32 6.35e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs11077998 0.967 rs4789790 chr17:80510789 G/A cg10255544 chr17:80519551 FOXK2 0.53 8.59 0.47 7.47e-16 Reticulocyte fraction of red cells; CESC cis rs6690583 0.623 rs2083284 chr1:85440023 C/T cg22153463 chr1:85462885 MCOLN2 0.77 7.26 0.41 4.21e-12 Serum sulfate level; CESC cis rs929354 0.772 rs2301916 chr7:156974127 G/T cg05182265 chr7:156933206 UBE3C -0.5 -7.2 -0.4 6.32e-12 Body mass index; CESC cis rs12464559 0.649 rs4664066 chr2:152632406 T/C cg01189475 chr2:152685088 ARL5A 0.65 5.69 0.33 3.36e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg00339695 chr16:24857497 SLC5A11 0.54 6.68 0.38 1.42e-10 Intelligence (multi-trait analysis); CESC cis rs561341 1.000 rs2470267 chr17:30274132 G/A cg19193384 chr17:30244184 NA -0.63 -6.55 -0.37 3.01e-10 Hip circumference adjusted for BMI; CESC cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg18016565 chr1:150552671 MCL1 -0.35 -5.82 -0.34 1.69e-8 Tonsillectomy; CESC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg18402987 chr7:1209562 NA 0.75 7.52 0.42 8.71e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs5758659 0.633 rs762995 chr22:42672124 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.31 -5.42 -0.32 1.36e-7 Cognitive function; CESC cis rs7178572 0.568 rs12911371 chr15:77689050 C/T cg22256960 chr15:77711686 NA -0.54 -6.95 -0.39 2.9e-11 Type 2 diabetes; CESC cis rs6687430 0.514 rs587916 chr1:10545590 G/A cg20482658 chr1:10539492 PEX14 -0.42 -8.71 -0.47 3.27e-16 Hand grip strength; CESC cis rs965469 1.000 rs6051790 chr20:3342994 C/T cg25506879 chr20:3388711 C20orf194 -0.56 -5.98 -0.34 7.29e-9 IFN-related cytopenia; CESC cis rs2735413 0.918 rs12918959 chr16:78081719 T/C cg04733911 chr16:78082701 NA -0.53 -8.97 -0.48 5.54e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs77972916 0.505 rs6753197 chr2:43527962 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -5.92 -0.34 9.78e-9 Granulocyte percentage of myeloid white cells; CESC cis rs1707322 1.000 rs11211204 chr1:46317864 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs75477785 0.590 rs12561766 chr1:209904252 T/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.85 5.21 0.3 3.82e-7 Cleft lip with or without cleft palate; CESC cis rs1728785 1.000 rs1749792 chr16:68569440 T/G cg02972257 chr16:68554789 NA -0.55 -6.28 -0.36 1.36e-9 Ulcerative colitis; CESC cis rs1348850 0.526 rs7588049 chr2:178390778 C/T cg22681709 chr2:178499509 PDE11A 0.51 5.42 0.32 1.37e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7605827 0.930 rs2277916 chr2:15494152 C/G cg19274914 chr2:15703543 NA 0.34 6.28 0.36 1.41e-9 Educational attainment (years of education); CESC cis rs62432291 0.681 rs294912 chr6:159667337 A/G cg14500486 chr6:159655392 FNDC1 -0.61 -5.93 -0.34 9.62e-9 Joint mobility (Beighton score); CESC cis rs870825 0.616 rs6834156 chr4:185639903 G/C cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg08736216 chr1:53307985 ZYG11A -0.42 -7.1 -0.4 1.16e-11 Monocyte count; CESC cis rs9549367 0.789 rs9549698 chr13:113877701 A/G cg18105134 chr13:113819100 PROZ -0.69 -9.14 -0.49 1.72e-17 Platelet distribution width; CESC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg07395648 chr5:131743802 NA -0.45 -5.83 -0.34 1.57e-8 Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17806437 chr15:42211581 EHD4 -0.61 -7.04 -0.4 1.64e-11 Gut microbiome composition (summer); CESC cis rs10771431 0.597 rs10771413 chr12:9354413 C/T cg08997352 chr12:9597637 DDX12 -0.71 -8.82 -0.48 1.57e-16 Breast size; CESC cis rs7998202 0.667 rs282587 chr13:113351662 G/A cg02820901 chr13:113351484 ATP11A 0.63 5.85 0.34 1.41e-8 Glycated hemoglobin levels; CESC cis rs3008870 1.000 rs3008873 chr1:67425770 G/A cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs6430585 0.528 rs309123 chr2:136761175 C/G cg07169764 chr2:136633963 MCM6 1.17 17.22 0.73 4.03e-45 Corneal structure; CESC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg04169830 chr2:88471460 THNSL2 0.35 5.37 0.31 1.72e-7 Response to metformin (IC50); CESC cis rs1215050 0.818 rs165238 chr4:98712138 G/T cg05340658 chr4:99064831 C4orf37 0.48 6.03 0.35 5.52e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs12477438 0.765 rs62154638 chr2:99639584 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs5769765 0.632 rs13056783 chr22:50259152 A/T cg26441486 chr22:50317300 CRELD2 -0.39 -5.44 -0.32 1.23e-7 Schizophrenia; CESC cis rs2997447 0.655 rs2275947 chr1:26383875 A/G cg19633962 chr1:26362018 EXTL1 -0.5 -5.45 -0.32 1.17e-7 QRS complex (12-leadsum); CESC cis rs2243480 1.000 rs1796228 chr7:66033084 G/A cg13147721 chr7:65941812 NA -0.93 -8.79 -0.47 1.98e-16 Diabetic kidney disease; CESC cis rs66725070 1 rs66725070 chr15:58267416 GACAT/G cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.07 -0.3 7.59e-7 Barrett's esophagus; CESC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 9.9 0.52 7.25e-20 Prudent dietary pattern; CESC cis rs722599 0.683 rs8011071 chr14:75286705 T/C cg11812906 chr14:75593930 NEK9 0.42 5.19 0.3 4.28e-7 IgG glycosylation; CESC cis rs4253772 0.591 rs11704586 chr22:46685274 T/C cg00784671 chr22:46762841 CELSR1 -0.57 -5.5 -0.32 8.75e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9581857 0.579 rs118061689 chr13:27974499 A/T cg01674679 chr13:27998804 GTF3A -0.67 -5.22 -0.31 3.54e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs1564271 0.553 rs2489583 chr10:26987698 A/G cg13837822 chr10:26931731 LOC731789 0.45 6.78 0.38 7.6e-11 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16866257 chr17:61905183 FTSJ3;PSMC5 0.51 6.72 0.38 1.09e-10 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.97 0.62 3.98e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4474465 0.920 rs10793321 chr11:78237566 A/G cg02023728 chr11:77925099 USP35 -0.41 -5.13 -0.3 5.67e-7 Alzheimer's disease (survival time); CESC cis rs7223966 1.000 rs8076717 chr17:61850301 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.53 -6.21 -0.36 2.06e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6748734 1.000 rs6748734 chr2:241837452 A/G cg04034577 chr2:241836375 C2orf54 -0.5 -8.67 -0.47 4.49e-16 Urinary metabolites; CESC cis rs9399137 0.507 rs11757723 chr6:135291293 C/T cg24558204 chr6:135376177 HBS1L 0.71 9.77 0.51 1.93e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15448726 chr12:53273497 NA -0.43 -6.43 -0.37 5.89e-10 Gambling; CESC cis rs7584330 0.554 rs10183995 chr2:238433307 G/A cg14458575 chr2:238380390 NA 0.49 5.42 0.32 1.35e-7 Prostate cancer; CESC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg06634786 chr22:41940651 POLR3H -0.7 -7.13 -0.4 9.69e-12 Vitiligo; CESC cis rs1879734 0.731 rs7519965 chr1:54163251 G/A cg23596471 chr1:54105337 GLIS1 0.35 5.45 0.32 1.14e-7 Mitral valve prolapse; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08882774 chr16:28875105 SH2B1 -0.53 -6.2 -0.36 2.2e-9 Gut microbiome composition (summer); CESC cis rs62432291 0.614 rs370434 chr6:159654551 C/G cg14500486 chr6:159655392 FNDC1 -0.62 -6.21 -0.36 2.04e-9 Joint mobility (Beighton score); CESC cis rs9796 0.621 rs557864 chr15:41471358 T/C cg18705301 chr15:41695430 NDUFAF1 0.44 6.46 0.37 4.86e-10 Menopause (age at onset); CESC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg25204440 chr1:209979598 IRF6 0.65 6.71 0.38 1.21e-10 Cleft lip with or without cleft palate; CESC cis rs6674176 0.628 rs4660758 chr1:44424879 A/C cg12908607 chr1:44402522 ARTN -0.44 -6.37 -0.36 8.33e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg02574844 chr11:5959923 NA 0.47 7.43 0.42 1.53e-12 DNA methylation (variation); CESC cis rs10754283 0.967 rs12058749 chr1:90105604 C/T cg21401794 chr1:90099060 LRRC8C 0.65 8.71 0.47 3.24e-16 Amyotrophic lateral sclerosis (sporadic); CESC cis rs763121 0.853 rs5750652 chr22:39048316 A/G cg06022373 chr22:39101656 GTPBP1 0.95 17.36 0.73 1.37e-45 Menopause (age at onset); CESC cis rs9916302 0.904 rs2338755 chr17:37419317 C/T cg20243544 chr17:37824526 PNMT -0.47 -6.02 -0.35 5.7e-9 Glomerular filtration rate (creatinine); CESC cis rs9303401 0.612 rs2526370 chr17:56487636 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.49 6.46 0.37 4.99e-10 Cognitive test performance; CESC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.54 0.37 3.16e-10 Prudent dietary pattern; CESC cis rs698833 0.798 rs4953082 chr2:44524064 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.44 5.51 0.32 8.31e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs854765 0.647 rs721669 chr17:18005073 A/G cg16928487 chr17:17741425 SREBF1 -0.53 -8.57 -0.47 8.9e-16 Total body bone mineral density; CESC cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg24308560 chr3:49941425 MST1R 0.61 9.02 0.48 4e-17 Intelligence (multi-trait analysis); CESC cis rs2243480 1.000 rs2961102 chr7:65424658 A/G cg18252515 chr7:66147081 NA -1.24 -12.07 -0.6 4.93e-27 Diabetic kidney disease; CESC cis rs748404 0.697 rs493177 chr15:43543258 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.5 7.65 0.43 3.76e-13 Lung cancer; CESC cis rs8072100 0.811 rs1912483 chr17:45443494 A/G cg25173405 chr17:45401733 C17orf57 -0.44 -5.72 -0.33 2.81e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7264396 0.635 rs6058366 chr20:34512172 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.07 -0.56 1.13e-23 Total cholesterol levels; CESC cis rs1538970 0.504 rs3790585 chr1:46023356 A/T cg06784218 chr1:46089804 CCDC17 0.49 7.27 0.41 4.15e-12 Platelet count; CESC cis rs6502050 0.835 rs4789672 chr17:80126603 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.61e-10 Life satisfaction; CESC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg25324976 chr17:61989376 CSHL1 0.36 5.42 0.32 1.37e-7 Prudent dietary pattern; CESC cis rs950169 0.922 rs62028133 chr15:84919375 A/C cg17507749 chr15:85114479 UBE2QP1 0.57 6.32 0.36 1.09e-9 Schizophrenia; CESC cis rs17376456 0.825 rs55947981 chr5:93278104 G/T cg25358565 chr5:93447407 FAM172A 1.11 10.04 0.53 2.56e-20 Diabetic retinopathy; CESC trans rs11601239 0.646 rs12790131 chr11:105567758 G/A cg15315312 chr2:176867285 KIAA1715 0.46 6.04 0.35 5.06e-9 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10235275 chr10:65225544 JMJD1C;LOC84989 0.57 6.15 0.35 2.81e-9 Gut microbiome composition (summer); CESC cis rs1784581 0.802 rs9365359 chr6:162423945 C/A cg17173639 chr6:162384350 PARK2 0.61 9.56 0.51 8.61e-19 Itch intensity from mosquito bite; CESC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg05863683 chr7:1912471 MAD1L1 0.42 6.34 0.36 1.01e-9 Bipolar disorder and schizophrenia; CESC cis rs9796 0.558 rs6492993 chr15:41526104 G/A cg20272979 chr15:41787780 ITPKA 0.38 5.57 0.32 6.19e-8 Menopause (age at onset); CESC cis rs748404 0.518 rs480108 chr15:43817406 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.56 7.19 0.4 6.82e-12 Lung cancer; CESC cis rs2228479 0.850 rs11639925 chr16:89908250 C/T cg14709524 chr16:89940631 TCF25 0.89 6.18 0.36 2.38e-9 Skin colour saturation; CESC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.58 7.36 0.41 2.34e-12 Prudent dietary pattern; CESC cis rs2573652 0.723 rs4577068 chr15:100515959 T/A cg09918751 chr15:100517450 ADAMTS17 -0.45 -8.74 -0.47 2.66e-16 Height; CESC cis rs10463316 0.894 rs10476980 chr5:150764157 A/G cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC cis rs3806843 0.838 rs2262567 chr5:140132134 T/A cg26395211 chr5:140044315 WDR55 0.39 5.09 0.3 6.79e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1559088 0.600 rs58173463 chr19:33596749 C/T cg27124370 chr19:33622961 WDR88 0.53 7.62 0.42 4.4e-13 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26434548 chr7:129074607 FAM40B 0.57 6.91 0.39 3.62e-11 Gut microbiome composition (summer); CESC cis rs9527 0.640 rs35195396 chr10:104928770 T/A cg04362960 chr10:104952993 NT5C2 0.42 5.25 0.31 3.11e-7 Arsenic metabolism; CESC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg18252515 chr7:66147081 NA 0.43 5.77 0.33 2.21e-8 Aortic root size; CESC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg26939375 chr7:64535504 NA 0.71 9.75 0.51 2.13e-19 Calcium levels; CESC cis rs10504229 0.679 rs2218271 chr8:58052446 T/A cg22535103 chr8:58192502 C8orf71 -0.66 -7.26 -0.41 4.29e-12 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.19e-17 Prudent dietary pattern; CESC cis rs9611519 0.780 rs2235852 chr22:41661154 G/T cg17376030 chr22:41985996 PMM1 0.44 5.33 0.31 2.13e-7 Neuroticism; CESC cis rs4803468 1.000 rs284654 chr19:41928724 G/A cg14132834 chr19:41945861 ATP5SL -0.64 -7.84 -0.43 1.07e-13 Height; CESC cis rs61931739 0.679 rs10844831 chr12:34311245 G/T cg19457237 chr12:34500585 NA -0.42 -5.67 -0.33 3.77e-8 Morning vs. evening chronotype; CESC cis rs78456975 1.000 rs13429866 chr2:1555211 C/A cg01028140 chr2:1542097 TPO -0.58 -5.9 -0.34 1.1e-8 Placebo response in major depressive disorder (% change in symptom score); CESC trans rs12310956 0.532 rs11052954 chr12:33993512 C/G cg26384229 chr12:38710491 ALG10B 0.46 6.3 0.36 1.27e-9 Morning vs. evening chronotype; CESC cis rs1707322 1.000 rs11211205 chr1:46321874 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7927771 0.965 rs17788930 chr11:47752775 A/G cg05585544 chr11:47624801 NA -0.51 -8.07 -0.44 2.38e-14 Subjective well-being; CESC cis rs10791097 0.667 rs4937584 chr11:130741761 A/G cg12179176 chr11:130786555 SNX19 0.65 10.06 0.53 2.26e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg02461776 chr11:598696 PHRF1 0.52 6.28 0.36 1.34e-9 Systemic lupus erythematosus; CESC cis rs3015469 0.596 rs1547078 chr14:51210853 T/C cg26011998 chr14:51135199 SAV1 0.55 5.85 0.34 1.43e-8 Plasma amyloid beta peptide concentrations (ABx-40); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08209184 chr20:35444560 C20orf117 -0.68 -8.27 -0.45 6.68e-15 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs4660889 chr1:46297331 C/T cg05343316 chr1:45956843 TESK2 0.44 5.47 0.32 1.05e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11792649 chr11:68664631 MRPL21 -0.57 -6.09 -0.35 3.87e-9 Gut microbiome composition (summer); CESC cis rs3806843 1.000 rs12717860 chr5:140171442 C/T cg26395211 chr5:140044315 WDR55 -0.44 -5.54 -0.32 7.4e-8 Depressive symptoms (multi-trait analysis); CESC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg00945038 chr17:61921165 SMARCD2 0.37 5.04 0.3 8.71e-7 Prudent dietary pattern; CESC cis rs9309473 1.000 rs6546839 chr2:73680508 G/C cg20560298 chr2:73613845 ALMS1 -0.46 -6.17 -0.35 2.53e-9 Metabolite levels; CESC cis rs7927771 1.000 rs11605774 chr11:47832793 G/A cg05585544 chr11:47624801 NA -0.51 -7.87 -0.44 9.36e-14 Subjective well-being; CESC cis rs7786808 0.741 rs11769149 chr7:158227127 A/G cg01191920 chr7:158217561 PTPRN2 0.45 7.9 0.44 7.37e-14 Obesity-related traits; CESC cis rs7809950 1.000 rs7809950 chr7:107237807 T/C cg23024343 chr7:107201750 COG5 0.44 6.02 0.35 5.73e-9 Coronary artery disease; CESC cis rs765787 0.530 rs1648286 chr15:45517386 G/C cg24006582 chr15:45444508 DUOX1 -0.58 -7.07 -0.4 1.4e-11 Uric acid levels; CESC cis rs2456568 0.867 rs1827931 chr11:93663170 T/C cg26875233 chr11:93583750 C11orf90 -0.31 -5.51 -0.32 8.57e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs1008375 1.000 rs3846357 chr4:17635887 A/T cg02297831 chr4:17616191 MED28 0.54 6.85 0.39 5.05e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28830936 1.000 rs17676742 chr15:41903048 A/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.36 -5.1 -0.3 6.47e-7 Diastolic blood pressure; CESC cis rs1348850 0.914 rs2060929 chr2:178280031 T/C cg22681709 chr2:178499509 PDE11A -0.42 -6.23 -0.36 1.79e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11098499 0.863 rs3822192 chr4:120445720 A/C cg24375607 chr4:120327624 NA 0.46 5.58 0.32 6e-8 Corneal astigmatism; CESC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg13206674 chr6:150067644 NUP43 0.43 6.03 0.35 5.54e-9 Lung cancer; CESC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg22963979 chr7:1858916 MAD1L1 -0.37 -5.04 -0.3 8.63e-7 Bipolar disorder and schizophrenia; CESC cis rs4253772 0.938 rs41371446 chr22:46637272 T/C cg18190219 chr22:46762943 CELSR1 -0.61 -5.84 -0.34 1.52e-8 LDL cholesterol;Cholesterol, total; CESC cis rs2204008 0.720 rs11180923 chr12:38255172 A/T cg13010199 chr12:38710504 ALG10B 0.48 6.04 0.35 5.23e-9 Bladder cancer; CESC cis rs992157 0.798 rs4674284 chr2:219161241 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.66 -8.66 -0.47 4.76e-16 Colorectal cancer; CESC cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.86 9.01 0.48 4.24e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9902453 0.872 rs34698290 chr17:28500465 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.74 0.43 2.08e-13 Coffee consumption (cups per day); CESC cis rs877282 0.629 rs78997110 chr10:764388 A/G cg17470449 chr10:769945 NA 0.47 5.14 0.3 5.33e-7 Uric acid levels; CESC cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -5.16 -0.3 4.84e-7 Personality dimensions; CESC cis rs80130819 0.748 rs2258342 chr12:48690363 T/C cg05342945 chr12:48394962 COL2A1 -0.48 -5.16 -0.3 4.82e-7 Prostate cancer; CESC cis rs3862030 0.694 rs12781742 chr10:104227469 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.37 -5.17 -0.3 4.71e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg00074818 chr8:8560427 CLDN23 0.36 5.29 0.31 2.51e-7 Obesity-related traits; CESC cis rs7666738 0.578 rs1989109 chr4:98881246 T/A cg03467027 chr4:99064603 C4orf37 0.42 5.25 0.31 3.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs929596 0.556 rs4477910 chr2:234643737 A/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.63 -8.46 -0.46 1.79e-15 Total bilirubin levels in HIV-1 infection; CESC cis rs12220238 0.730 rs10740421 chr10:75941002 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.59 5.35 0.31 1.94e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs778371 0.522 rs6704768 chr2:233592501 C/T cg08000102 chr2:233561755 GIGYF2 0.8 13.57 0.64 3.29e-32 Schizophrenia; CESC cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg03467027 chr4:99064603 C4orf37 0.45 5.61 0.33 4.97e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7726839 0.540 rs4957081 chr5:646418 G/C cg16447950 chr5:562315 NA -0.58 -6.53 -0.37 3.38e-10 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20776722 chr5:130970743 RAPGEF6 -0.6 -7.09 -0.4 1.22e-11 Gut microbiome composition (summer); CESC cis rs1538970 1.000 rs7417107 chr1:45831915 G/C cg05343316 chr1:45956843 TESK2 0.76 10.54 0.54 6.54e-22 Platelet count; CESC cis rs11864453 0.679 rs2303285 chr16:72124495 A/C cg01557791 chr16:72042693 DHODH -0.43 -5.57 -0.32 6.39e-8 Fibrinogen levels; CESC cis rs9403521 1.000 rs6901659 chr6:143985106 T/C cg18240653 chr6:144019428 PHACTR2 -0.5 -5.57 -0.32 6.28e-8 Obesity-related traits; CESC cis rs11264213 0.681 rs72659670 chr1:36236750 G/C cg27506609 chr1:36549197 TEKT2 0.65 5.34 0.31 1.97e-7 Schizophrenia; CESC cis rs7937682 0.883 rs490492 chr11:111465150 C/T cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27600766 chr18:21594250 TTC39C 0.58 6.15 0.35 2.8e-9 Gut microbiome composition (summer); CESC cis rs3540 0.574 rs2526000 chr15:90962626 C/T cg10434728 chr15:90938212 IQGAP1 0.4 6.97 0.39 2.46e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg18591801 chr3:52553433 STAB1 -0.29 -5.61 -0.33 5.18e-8 Electroencephalogram traits; CESC cis rs10493773 0.502 rs12066742 chr1:86081149 A/G cg17807903 chr1:86174739 ZNHIT6 -0.44 -5.74 -0.33 2.58e-8 Urate levels in overweight individuals; CESC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg07701084 chr6:150067640 NUP43 0.41 5.42 0.32 1.33e-7 Lung cancer; CESC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg24675658 chr1:53192096 ZYG11B 0.53 6.73 0.38 1.04e-10 Monocyte count; CESC cis rs4722166 0.630 rs13311199 chr7:22789793 A/C cg05265849 chr7:22767390 IL6 0.58 7.39 0.41 1.9e-12 Lung cancer; CESC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg16680214 chr1:154839983 KCNN3 -0.52 -8.16 -0.45 1.36e-14 Prostate cancer; CESC cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg06636001 chr8:8085503 FLJ10661 -0.59 -7.55 -0.42 7.07e-13 Neuroticism; CESC cis rs16866061 1.000 rs17480230 chr2:225399864 G/A cg12698349 chr2:225449008 CUL3 0.76 11.25 0.57 2.89e-24 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg11764359 chr7:65958608 NA -0.78 -11.07 -0.56 1.19e-23 Aortic root size; CESC cis rs7267979 1.000 rs4815406 chr20:25341316 C/G cg08601574 chr20:25228251 PYGB -0.38 -5.46 -0.32 1.12e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03828693 chr10:63661686 ARID5B -0.44 -6.02 -0.35 5.94e-9 Asthma; CESC cis rs2625529 0.652 rs2034879 chr15:72429989 A/G cg16672083 chr15:72433130 SENP8 -0.46 -6.84 -0.39 5.45e-11 Red blood cell count; CESC trans rs61931739 0.500 rs11053280 chr12:34559297 G/T cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg11644478 chr21:40555479 PSMG1 0.61 8.24 0.45 7.75e-15 Cognitive function; CESC cis rs858239 0.600 rs1468592 chr7:23140647 C/T cg23682824 chr7:23144976 KLHL7 -0.54 -7.74 -0.43 2.08e-13 Cerebrospinal fluid biomarker levels; CESC cis rs9815354 0.857 rs73830583 chr3:41996948 C/T cg03022575 chr3:42003672 ULK4 0.68 6.03 0.35 5.51e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg18350739 chr11:68623251 NA -0.46 -7.04 -0.4 1.61e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2710642 0.888 rs13418889 chr2:63079775 T/C cg17519650 chr2:63277830 OTX1 0.51 6.65 0.38 1.64e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs8067354 0.645 rs72838857 chr17:57836767 A/G cg02344993 chr17:57696989 CLTC 0.57 5.97 0.34 7.53e-9 Hemoglobin concentration; CESC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg18252515 chr7:66147081 NA 0.47 6.06 0.35 4.68e-9 Aortic root size; CESC cis rs826838 1.000 rs34254519 chr12:39041235 G/A cg26384229 chr12:38710491 ALG10B 0.8 13.76 0.65 7.12e-33 Heart rate; CESC cis rs12618769 0.597 rs3729568 chr2:99100196 T/G cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.68e-7 Bipolar disorder; CESC cis rs7605827 0.930 rs2111451 chr2:15654483 T/C cg19274914 chr2:15703543 NA 0.32 5.7 0.33 3.17e-8 Educational attainment (years of education); CESC cis rs763014 0.898 rs35666389 chr16:629458 A/G cg09263875 chr16:632152 PIGQ 0.67 11.08 0.56 1.07e-23 Height; CESC trans rs7922314 0.571 rs16917977 chr10:64729208 T/A cg06935979 chr1:232941706 KIAA1383 -0.66 -5.99 -0.35 6.67e-9 Cutaneous psoriasis; CESC cis rs13242816 1.000 rs13247015 chr7:116095623 A/C cg04696780 chr7:116139425 CAV2 -0.63 -5.66 -0.33 3.95e-8 P wave duration; CESC cis rs7447927 0.950 rs13181561 chr5:138850905 A/G cg11459648 chr5:138714337 SLC23A1 -0.46 -6.96 -0.39 2.74e-11 Esophageal squamous cell carcinoma; CESC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg01097406 chr16:89675127 NA 0.38 5.49 0.32 9.25e-8 Vitiligo; CESC cis rs6963495 0.818 rs56165465 chr7:105180384 C/T cg19920283 chr7:105172520 RINT1 0.77 8.17 0.45 1.24e-14 Bipolar disorder (body mass index interaction); CESC cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg10556349 chr10:835070 NA 0.57 5.48 0.32 9.87e-8 Eosinophil percentage of granulocytes; CESC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg04944784 chr2:26401820 FAM59B -0.65 -7.47 -0.42 1.16e-12 Gut microbiome composition (summer); CESC trans rs561341 0.883 rs2074102 chr17:30228884 G/A cg27661571 chr11:113659931 NA -0.64 -6.33 -0.36 1.02e-9 Hip circumference adjusted for BMI; CESC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg15664640 chr17:80829946 TBCD -0.38 -5.64 -0.33 4.4e-8 Breast cancer; CESC cis rs61931739 0.658 rs10772149 chr12:34285498 A/G cg19457237 chr12:34500585 NA -0.39 -5.36 -0.31 1.84e-7 Morning vs. evening chronotype; CESC cis rs782590 0.935 rs2586954 chr2:55892261 A/C cg18811423 chr2:55921094 PNPT1 0.79 12.54 0.61 1.25e-28 Metabolic syndrome; CESC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg03467027 chr4:99064603 C4orf37 0.45 5.61 0.33 4.97e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6964587 1.000 rs2269727 chr7:91752690 C/A cg17063962 chr7:91808500 NA 0.59 8.13 0.45 1.69e-14 Breast cancer; CESC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.49 6.11 0.35 3.61e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs13125930 chr4:98654695 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.39 0.31 1.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.23 0.31 3.5e-7 Menopause (age at onset); CESC cis rs5753618 0.583 rs5753612 chr22:31821479 T/C cg02404636 chr22:31891804 SFI1 0.39 5.37 0.31 1.71e-7 Colorectal cancer; CESC cis rs7605827 0.897 rs11682528 chr2:15533183 T/C cg19274914 chr2:15703543 NA 0.34 6.11 0.35 3.46e-9 Educational attainment (years of education); CESC cis rs763121 0.853 rs4821811 chr22:39075145 C/T cg14440974 chr22:39074834 NA -0.42 -5.73 -0.33 2.77e-8 Menopause (age at onset); CESC cis rs589448 0.900 rs588493 chr12:69751986 G/A cg22834771 chr12:69754056 YEATS4 -0.54 -7.24 -0.41 4.92e-12 Cerebrospinal fluid biomarker levels; CESC cis rs829883 0.659 rs11109522 chr12:98930964 C/T cg25150519 chr12:98850993 NA -0.64 -7.87 -0.44 8.8e-14 Colorectal adenoma (advanced); CESC cis rs938554 0.513 rs3775946 chr4:9995256 A/G cg11266682 chr4:10021025 SLC2A9 0.5 7.28 0.41 3.69e-12 Blood metabolite levels; CESC cis rs6460942 0.915 rs17444044 chr7:12458736 A/G cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs2845885 0.793 rs57779243 chr11:63882363 G/T cg05555928 chr11:63887634 MACROD1 -0.54 -5.99 -0.35 6.69e-9 Body mass index; CESC cis rs6121246 0.954 rs6121245 chr20:30432060 G/A cg13852791 chr20:30311386 BCL2L1 0.73 7.54 0.42 7.5e-13 Mean corpuscular hemoglobin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13486387 chr9:94124044 AUH 0.56 6.18 0.35 2.43e-9 Gut microbiome composition (summer); CESC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg08859206 chr1:53392774 SCP2 -0.62 -9.03 -0.49 3.65e-17 Monocyte count; CESC cis rs17253792 0.822 rs76918910 chr14:56058762 T/C cg01858014 chr14:56050164 KTN1 -0.87 -6.75 -0.38 9.11e-11 Putamen volume; CESC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg02034447 chr16:89574710 SPG7 0.5 6.33 0.36 1.04e-9 Multiple myeloma (IgH translocation); CESC cis rs1348850 0.567 rs2222711 chr2:178534110 G/T cg23306229 chr2:178417860 TTC30B 0.52 6.11 0.35 3.47e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs897984 0.520 rs12928081 chr16:30885159 T/G cg02466173 chr16:30829666 NA 0.45 6.56 0.37 2.82e-10 Dementia with Lewy bodies; CESC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.06 -0.3 7.85e-7 Glomerular filtration rate (creatinine); CESC trans rs7937682 1.000 rs12363179 chr11:111568091 G/A cg18187862 chr3:45730750 SACM1L -0.53 -6.07 -0.35 4.52e-9 Primary sclerosing cholangitis; CESC cis rs3857536 0.740 rs7745163 chr6:66889936 A/G cg07460842 chr6:66804631 NA -0.42 -5.39 -0.31 1.56e-7 Blood trace element (Cu levels); CESC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg13206674 chr6:150067644 NUP43 0.44 6.3 0.36 1.24e-9 Lung cancer; CESC cis rs11031096 0.621 rs12282967 chr11:4191477 A/T cg18678763 chr11:4115507 RRM1 -0.4 -5.18 -0.3 4.46e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs61931739 0.817 rs2636084 chr12:34130210 G/A cg26384229 chr12:38710491 ALG10B 0.44 6.05 0.35 5.02e-9 Morning vs. evening chronotype; CESC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg22433210 chr17:43662623 NA 0.62 8.04 0.44 2.96e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg12386194 chr3:101231763 SENP7 0.49 5.86 0.34 1.33e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg24733560 chr20:60626293 TAF4 0.45 6.38 0.37 7.76e-10 Body mass index; CESC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs5753037 0.639 rs5997534 chr22:30220190 G/A cg01021169 chr22:30184971 ASCC2 -0.47 -6.6 -0.38 2.22e-10 Type 1 diabetes; CESC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.68 0.61 4e-29 Gut microbiome composition (summer); CESC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg02807482 chr3:125708958 NA -0.4 -5.25 -0.31 3.13e-7 Blood pressure (smoking interaction); CESC cis rs5769765 0.542 rs5770720 chr22:50253101 A/G cg02269571 chr22:50332266 NA 0.46 5.45 0.32 1.16e-7 Schizophrenia; CESC cis rs9814567 0.896 rs13089566 chr3:134349710 G/C cg15484384 chr3:134203672 ANAPC13;CEP63 0.32 5.11 0.3 6.06e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4450131 0.522 rs34209544 chr10:126350452 G/C cg20435097 chr10:126320824 FAM53B 0.29 5.14 0.3 5.35e-7 White blood cell count (basophil); CESC cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg20573242 chr4:122745356 CCNA2 0.65 8.05 0.44 2.81e-14 Type 2 diabetes; CESC cis rs9796 0.870 rs3101436 chr15:41287689 A/G cg18705301 chr15:41695430 NDUFAF1 0.43 6.36 0.36 8.58e-10 Menopause (age at onset); CESC cis rs11122272 0.735 rs2808601 chr1:231536571 A/G cg06096015 chr1:231504339 EGLN1 0.39 5.53 0.32 7.83e-8 Hemoglobin concentration; CESC cis rs12220238 0.915 rs11001021 chr10:76139657 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.11 0.3 6.13e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg17372223 chr3:52568218 NT5DC2 0.51 7.94 0.44 5.81e-14 Electroencephalogram traits; CESC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg25204440 chr1:209979598 IRF6 0.65 6.71 0.38 1.21e-10 Cleft lip with or without cleft palate; CESC cis rs8077577 0.708 rs4556848 chr17:18134867 C/G cg16794390 chr17:18148240 FLII -0.44 -6.58 -0.37 2.58e-10 Obesity-related traits; CESC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.62 0.51 5.54e-19 Platelet count; CESC cis rs4523957 0.928 rs8074850 chr17:2187931 C/A cg16513277 chr17:2031491 SMG6 -0.56 -7.41 -0.41 1.68e-12 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4746818 0.892 rs2394505 chr10:70871598 A/G cg11621586 chr10:70884670 VPS26A -0.9 -9.91 -0.52 6.89e-20 Left atrial antero-posterior diameter; CESC cis rs4141404 0.851 rs5749248 chr22:31683711 C/A cg00478049 chr22:31556069 RNF185 0.48 5.06 0.3 8.01e-7 Paclitaxel-induced neuropathy; CESC cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs6032067 0.704 rs35009666 chr20:43786020 C/T cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC trans rs61931739 1.000 rs12427391 chr12:34022891 A/G cg26384229 chr12:38710491 ALG10B -0.46 -6.28 -0.36 1.4e-9 Morning vs. evening chronotype; CESC cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.17 0.3 4.69e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1729951 0.575 rs1654923 chr3:136692620 A/T cg04103450 chr3:136751342 NA 0.4 5.31 0.31 2.32e-7 Neuroticism; CESC cis rs7255436 0.931 rs7249520 chr19:8446056 G/A cg10174797 chr19:8464628 RAB11B 0.41 5.96 0.34 8.11e-9 HDL cholesterol; CESC cis rs1144333 0.655 rs76532097 chr1:76320759 G/C cg10523679 chr1:76189770 ACADM 0.56 5.36 0.31 1.8e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs11997175 0.646 rs66856932 chr8:33700782 A/G ch.8.33884649F chr8:33765107 NA 0.57 7.56 0.42 6.61e-13 Body mass index; CESC cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9910055 0.529 rs228764 chr17:42185469 A/G cg13607699 chr17:42295918 UBTF -0.44 -5.51 -0.32 8.36e-8 Total body bone mineral density; CESC cis rs10751667 0.643 rs6597969 chr11:928843 C/T cg06064525 chr11:970664 AP2A2 -0.52 -10.25 -0.53 5.74e-21 Alzheimer's disease (late onset); CESC cis rs854765 0.583 rs8080823 chr17:17864048 T/C cg16928487 chr17:17741425 SREBF1 -0.6 -10.08 -0.53 1.98e-20 Total body bone mineral density; CESC cis rs8114671 0.836 rs4911461 chr20:33629993 A/C cg07148914 chr20:33460835 GGT7 -0.41 -5.31 -0.31 2.28e-7 Height; CESC cis rs3747547 0.710 rs7864677 chr9:37949969 C/T cg13774184 chr9:37916125 SHB -0.56 -5.87 -0.34 1.32e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs9287719 0.781 rs6732671 chr2:10759149 T/G cg00105475 chr2:10696890 NA 0.35 5.07 0.3 7.65e-7 Prostate cancer; CESC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg27125505 chr17:43679177 LOC644172 0.47 6.33 0.36 1.04e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.91 -0.34 1.05e-8 Total body bone mineral density; CESC cis rs854765 0.693 rs35451946 chr17:17764061 C/G cg09796270 chr17:17721594 SREBF1 -0.42 -6.0 -0.35 6.49e-9 Total body bone mineral density; CESC cis rs11785693 0.862 rs6994150 chr8:4996630 T/G cg26367366 chr8:4980734 NA 0.75 7.3 0.41 3.44e-12 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs6748734 1.000 rs4675863 chr2:241830763 A/T cg15164180 chr2:241846931 NA -0.35 -5.09 -0.3 6.67e-7 Urinary metabolites; CESC cis rs6502050 0.871 rs6502054 chr17:80066715 G/A cg11859384 chr17:80120422 CCDC57 0.4 5.51 0.32 8.47e-8 Life satisfaction; CESC trans rs9467711 0.606 rs9379900 chr6:26603811 A/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.73 6.12 0.35 3.38e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7264396 0.570 rs6060717 chr20:34544647 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.57 6.97 0.39 2.48e-11 Total cholesterol levels; CESC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg27165867 chr14:105738592 BRF1 -0.52 -5.64 -0.33 4.33e-8 Mean platelet volume;Platelet distribution width; CESC cis rs66573146 0.831 rs68111914 chr4:6986677 C/T cg00086871 chr4:6988644 TBC1D14 1.18 7.63 0.42 4.18e-13 Granulocyte percentage of myeloid white cells; CESC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg04315214 chr1:2043799 PRKCZ -0.44 -7.05 -0.4 1.53e-11 Height; CESC cis rs1062753 0.771 rs5751245 chr22:42620940 T/C cg00645731 chr22:42541494 CYP2D7P1 0.38 6.2 0.36 2.18e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs35110281 0.805 rs4818843 chr21:45006607 C/T cg01579765 chr21:45077557 HSF2BP -0.57 -9.49 -0.5 1.43e-18 Mean corpuscular volume; CESC cis rs9868809 0.881 rs6773261 chr3:48675064 A/G cg07636037 chr3:49044803 WDR6 -0.67 -5.64 -0.33 4.29e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg03188948 chr7:1209495 NA 0.46 5.89 0.34 1.18e-8 Longevity;Endometriosis; CESC cis rs8044868 0.530 rs2550870 chr16:72070129 C/T cg16558253 chr16:72132732 DHX38 -0.37 -5.77 -0.33 2.19e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC trans rs8073060 0.544 rs2626626 chr17:34026717 A/G cg19694781 chr19:47549865 TMEM160 -0.69 -6.3 -0.36 1.22e-9 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC trans rs9850225 0.719 rs4856616 chr3:80466481 A/C cg04945395 chr3:111805408 C3orf52 -0.42 -6.13 -0.35 3.09e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs10927875 0.541 rs1048334 chr1:16340761 T/C cg22431228 chr1:16359049 CLCNKA -0.52 -9.96 -0.52 4.74e-20 Dilated cardiomyopathy; CESC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg18402987 chr7:1209562 NA 0.76 7.56 0.42 6.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4474465 0.790 rs10751293 chr11:78250956 A/T cg27205649 chr11:78285834 NARS2 0.42 5.31 0.31 2.3e-7 Alzheimer's disease (survival time); CESC cis rs1023500 0.573 rs133380 chr22:42468910 C/T cg15557168 chr22:42548783 NA -0.43 -6.5 -0.37 3.86e-10 Schizophrenia; CESC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg15595755 chr5:1867978 NA 0.53 8.74 0.47 2.68e-16 Cardiovascular disease risk factors; CESC cis rs4604732 0.631 rs1106721 chr1:247624676 A/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10774155 chr7:65338427 VKORC1L1 -0.52 -6.7 -0.38 1.22e-10 Asthma; CESC cis rs2425143 0.818 rs7272684 chr20:34424692 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -6.06 -0.35 4.71e-9 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10519082 chr1:245026741 HNRNPU 0.57 6.07 0.35 4.39e-9 Gut microbiome composition (summer); CESC cis rs8114671 0.836 rs3746432 chr20:33592763 C/T cg24642439 chr20:33292090 TP53INP2 -0.45 -5.43 -0.32 1.25e-7 Height; CESC cis rs2274273 0.967 rs10137409 chr14:55611441 A/C cg04306507 chr14:55594613 LGALS3 0.28 5.27 0.31 2.77e-7 Protein biomarker; CESC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg05861140 chr6:150128134 PCMT1 -0.35 -5.07 -0.3 7.45e-7 Lung cancer; CESC cis rs1348850 0.874 rs12996447 chr2:178283592 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.72 10.1 0.53 1.7e-20 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9858542 0.903 rs11921590 chr3:49644193 T/C cg03060546 chr3:49711283 APEH -0.55 -6.5 -0.37 4.04e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25968378 chr3:42544131 VIPR1 0.54 6.38 0.36 7.7e-10 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.83 8.86 0.48 1.15e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7772486 0.875 rs2777481 chr6:146310036 G/T cg05347473 chr6:146136440 FBXO30 0.55 7.17 0.4 7.51e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs13098911 0.540 rs78380307 chr3:46174331 T/C cg10236987 chr1:228114221 WNT9A 0.6 6.22 0.36 1.93e-9 Celiac disease; CESC cis rs2933343 0.649 rs789216 chr3:128594503 A/C cg25356066 chr3:128598488 ACAD9 0.61 8.38 0.46 3.06e-15 IgG glycosylation; CESC cis rs11792861 0.926 rs2271878 chr9:111868885 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.41 5.15 0.3 5.08e-7 Menarche (age at onset); CESC cis rs3859192 0.561 rs9916158 chr17:38182229 G/T cg17467752 chr17:38218738 THRA -0.43 -5.87 -0.34 1.28e-8 White blood cell count; CESC cis rs17253792 0.822 rs10147431 chr14:56091841 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.98 0.34 7.23e-9 Putamen volume; CESC cis rs9291683 0.609 rs12500810 chr4:10031068 G/A cg02734326 chr4:10020555 SLC2A9 0.48 6.84 0.39 5.53e-11 Bone mineral density; CESC cis rs7085104 0.632 rs7096475 chr10:104609676 A/G cg04362960 chr10:104952993 NT5C2 0.49 6.62 0.38 1.98e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs9640161 0.830 rs17173681 chr7:150059414 A/G cg21361702 chr7:150065534 REPIN1 -0.66 -8.15 -0.45 1.41e-14 Blood protein levels;Circulating chemerin levels; CESC cis rs2095921 1 rs2095921 chr1:11033322 C/G cg27631724 chr1:11040367 C1orf127 0.38 6.21 0.36 2.02e-9 Male-pattern baldness; CESC cis rs67460515 0.531 rs13315565 chr3:160754626 G/C cg03342759 chr3:160939853 NMD3 -0.53 -6.84 -0.39 5.44e-11 Parkinson's disease; CESC cis rs763121 0.853 rs9610993 chr22:39042818 C/A cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC cis rs6500602 0.702 rs4786511 chr16:4571645 C/T cg08645402 chr16:4508243 NA 0.54 8.71 0.47 3.29e-16 Schizophrenia; CESC cis rs425277 0.958 rs262687 chr1:2117155 G/A cg24578937 chr1:2090814 PRKCZ 0.53 8.94 0.48 7.03e-17 Height; CESC cis rs9911578 1.000 rs6503870 chr17:56659018 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.23 0.31 3.51e-7 Intelligence (multi-trait analysis); CESC cis rs1008375 1.000 rs3846357 chr4:17635887 A/T cg16339924 chr4:17578868 LAP3 0.56 7.13 0.4 9.83e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg26338869 chr17:61819248 STRADA 0.5 6.21 0.36 2.06e-9 Prudent dietary pattern; CESC cis rs926938 0.520 rs6671984 chr1:115257521 C/T cg12756093 chr1:115239321 AMPD1 -0.54 -6.67 -0.38 1.52e-10 Autism; CESC cis rs1550582 1.000 rs76091740 chr8:135514419 C/T cg17885191 chr8:135476712 NA 0.62 7.12 0.4 1.03e-11 Educational attainment; CESC cis rs1957429 0.522 rs73279816 chr14:65348375 G/A cg23373153 chr14:65346875 NA -0.92 -6.7 -0.38 1.21e-10 Pediatric areal bone mineral density (radius); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18163118 chr11:67250585 AIP 0.66 7.6 0.42 5.13e-13 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg25072359 chr17:41440525 NA -0.39 -5.29 -0.31 2.63e-7 Menopause (age at onset); CESC cis rs8072100 0.512 rs9303533 chr17:45386540 A/G cg08085267 chr17:45401833 C17orf57 -0.51 -6.82 -0.39 6.16e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7772486 0.875 rs2748501 chr6:146312258 G/A cg05347473 chr6:146136440 FBXO30 0.56 7.32 0.41 2.96e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs34779708 0.931 rs11010082 chr10:35351155 A/G cg04310649 chr10:35416472 CREM -0.54 -6.43 -0.37 5.93e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs9902453 0.726 rs3115092 chr17:28036350 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.78 10.88 0.56 4.97e-23 Coffee consumption (cups per day); CESC cis rs12618769 0.597 rs3754888 chr2:99090674 T/C cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs11166629 1.000 rs1545240 chr8:135642632 A/C cg27224718 chr8:135614730 ZFAT 0.49 6.02 0.35 5.93e-9 Smoking quantity; CESC trans rs116095464 0.558 rs3213838 chr5:223890 G/C cg00938859 chr5:1591904 SDHAP3 0.61 6.78 0.38 7.58e-11 Breast cancer; CESC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg08888203 chr3:10149979 C3orf24 0.47 5.28 0.31 2.69e-7 Alzheimer's disease; CESC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg16405210 chr4:1374714 KIAA1530 -0.6 -8.17 -0.45 1.3e-14 Longevity; CESC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg08027265 chr7:2291960 NA -0.39 -5.83 -0.34 1.62e-8 Bipolar disorder and schizophrenia; CESC trans rs11764590 0.724 rs55789728 chr7:2107649 A/G cg11693508 chr17:37793320 STARD3 0.53 6.04 0.35 5.25e-9 Neuroticism; CESC cis rs9902453 0.619 rs2255489 chr17:28084974 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -8.47 -0.46 1.76e-15 Coffee consumption (cups per day); CESC trans rs208520 0.690 rs12194057 chr6:66745616 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.05 0.59 5.77e-27 Exhaled nitric oxide output; CESC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg11987759 chr7:65425863 GUSB -0.48 -6.56 -0.37 2.82e-10 Aortic root size; CESC cis rs4843747 0.749 rs13333619 chr16:88072076 C/T cg17633681 chr16:88106987 BANP 0.69 9.07 0.49 2.69e-17 Menopause (age at onset); CESC cis rs9911578 1.000 rs12952832 chr17:56906254 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 3.04e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2795502 0.882 rs3123754 chr10:43339011 G/A cg27426351 chr10:43362370 NA -0.45 -5.5 -0.32 8.91e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10690677 chr1:87019175 CLCA4 -0.67 -7.65 -0.43 3.63e-13 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg11764359 chr7:65958608 NA 0.73 10.54 0.54 6.24e-22 Aortic root size; CESC cis rs733592 0.507 rs7299704 chr12:48444488 A/G cg04545296 chr12:48745243 ZNF641 0.29 5.44 0.32 1.19e-7 Plateletcrit; CESC cis rs10979 1.000 rs9390104 chr6:143890978 T/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs1568889 0.838 rs7131053 chr11:28143312 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.23 0.63 5.14e-31 Bipolar disorder; CESC cis rs1355223 0.506 rs11032899 chr11:34870234 G/A cg11622362 chr11:34938112 PDHX;APIP 0.44 5.14 0.3 5.23e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg05754148 chr16:3507555 NAT15 -0.57 -7.17 -0.4 7.62e-12 Tuberculosis; CESC cis rs1124376 0.816 rs62243131 chr3:20141308 A/G cg05072819 chr3:20081367 KAT2B 0.47 5.44 0.32 1.19e-7 Bipolar disorder and schizophrenia; CESC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg09359103 chr1:154839909 KCNN3 -0.68 -13.1 -0.63 1.47e-30 Prostate cancer; CESC cis rs6580649 0.941 rs1859441 chr12:48423233 C/T cg05342945 chr12:48394962 COL2A1 0.53 6.07 0.35 4.33e-9 Lung cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21512275 chr2:157198069 NA -0.48 -6.89 -0.39 4.04e-11 Gambling; CESC cis rs9814567 1.000 rs9289475 chr3:134236459 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.08 -0.35 4.09e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4481887 0.927 rs4603165 chr1:248473799 T/A cg00666640 chr1:248458726 OR2T12 0.36 6.12 0.35 3.33e-9 Common traits (Other); CESC cis rs12220238 1.000 rs73284257 chr10:76000710 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.63 5.75 0.33 2.5e-8 Soluble interleukin-2 receptor subunit alpha; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg05280932 chr6:88045306 C6orf162 0.44 6.31 0.36 1.16e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1371867 0.875 rs2439456 chr8:101336874 C/T cg11906718 chr8:101322791 RNF19A 0.47 5.95 0.34 8.49e-9 Atrioventricular conduction; CESC cis rs546131 1.000 rs546131 chr11:34851760 G/C cg11058730 chr11:34937778 PDHX;APIP 0.49 6.17 0.35 2.53e-9 Lung disease severity in cystic fibrosis; CESC cis rs7091068 0.518 rs913045 chr10:95431535 C/T cg20715218 chr10:95462985 C10orf4 0.47 6.07 0.35 4.47e-9 Urinary tract infection frequency; CESC cis rs2637266 0.703 rs846577 chr10:78500277 A/G cg18941641 chr10:78392320 NA 0.38 7.31 0.41 3.08e-12 Pulmonary function; CESC cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.524 rs10742820 chr11:47781057 C/T cg05585544 chr11:47624801 NA -0.32 -5.11 -0.3 6.09e-7 Subjective well-being; CESC cis rs926938 0.505 rs360629 chr1:115414733 A/G cg12756093 chr1:115239321 AMPD1 0.45 6.01 0.35 6.15e-9 Autism; CESC cis rs6060717 0.536 rs6060670 chr20:34481143 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.7 0.33 3.16e-8 Hip circumference adjusted for BMI; CESC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs2456568 0.778 rs7944194 chr11:93682413 C/G cg05188948 chr11:93754288 HEPHL1 -0.27 -5.23 -0.31 3.46e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs950169 0.526 rs698620 chr15:85177208 G/A cg11189052 chr15:85197271 WDR73 -0.48 -6.47 -0.37 4.79e-10 Schizophrenia; CESC cis rs10791097 0.694 rs10894273 chr11:130742155 G/T cg12179176 chr11:130786555 SNX19 0.65 10.06 0.53 2.26e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs561341 1.000 rs117029332 chr17:30266085 C/G cg20587970 chr11:113659929 NA -1.43 -18.77 -0.76 1.45e-50 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11928684 chr11:47291227 MADD 0.52 5.99 0.35 6.65e-9 Gut microbiome composition (summer); CESC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg07092213 chr7:1199455 ZFAND2A -0.46 -5.48 -0.32 1.01e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7973683 0.541 rs7976319 chr12:124388511 A/G cg00084347 chr12:124393913 DNAH10 0.27 5.53 0.32 7.67e-8 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21581312 chr15:35529473 LOC723972 -0.48 -6.65 -0.38 1.69e-10 Gut microbiota (bacterial taxa); CESC trans rs2099077 0.867 rs62365561 chr5:102795941 A/C cg07434438 chr16:72961899 ZFHX3 0.49 6.67 0.38 1.5e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg25072359 chr17:41440525 NA 0.48 6.54 0.37 3.13e-10 Menopause (age at onset); CESC cis rs7937682 0.889 rs567859 chr11:111486738 A/G cg09085632 chr11:111637200 PPP2R1B -0.95 -14.6 -0.67 8.26e-36 Primary sclerosing cholangitis; CESC cis rs2479106 0.591 rs913783 chr9:126434103 C/T cg16191174 chr9:126692580 DENND1A -0.36 -5.03 -0.3 9.02e-7 Polycystic ovary syndrome; CESC trans rs28595532 0.557 rs12498329 chr4:119311524 C/T cg26518628 chr1:97050305 NA -0.51 -6.04 -0.35 5.25e-9 Cannabis dependence symptom count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06168166 chr11:47372949 MYBPC3 -0.49 -6.15 -0.35 2.82e-9 Gut microbiome composition (summer); CESC trans rs11039798 1.000 rs6485856 chr11:48556298 G/C cg15704280 chr7:45808275 SEPT13 0.7 6.53 0.37 3.42e-10 Axial length; CESC cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg18350739 chr11:68623251 NA -0.44 -6.35 -0.36 9.53e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs5769765 0.913 rs2319462 chr22:50263370 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs9486719 1.000 rs11152969 chr6:96908712 A/C cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.45e-15 Migraine;Coronary artery disease; CESC cis rs2243480 1.000 rs709607 chr7:65449541 C/G cg13147721 chr7:65941812 NA 0.69 6.55 0.37 2.98e-10 Diabetic kidney disease; CESC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg24250549 chr1:154909240 PMVK 0.64 9.31 0.5 5.09e-18 Prostate cancer; CESC cis rs7512552 0.839 rs1260386 chr1:150369622 G/T cg15654264 chr1:150340011 RPRD2 0.4 5.28 0.31 2.65e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs131777 0.575 rs131760 chr22:51011936 T/C cg25309564 chr22:51001381 C22orf41 0.6 7.54 0.42 7.64e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7267979 1.000 rs6037121 chr20:25428311 G/A cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.4e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs11122272 0.766 rs2808608 chr1:231543175 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -7.97 -0.44 4.66e-14 Hemoglobin concentration; CESC cis rs4654899 1.000 rs6700718 chr1:21299363 A/C cg05370193 chr1:21551575 ECE1 -0.36 -5.28 -0.31 2.67e-7 Superior frontal gyrus grey matter volume; CESC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg23131131 chr22:24373011 LOC391322 -0.77 -11.18 -0.57 5.1900000000000004e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs61931739 0.500 rs11053167 chr12:34387092 A/C cg13010199 chr12:38710504 ALG10B 0.46 6.03 0.35 5.51e-9 Morning vs. evening chronotype; CESC cis rs4930561 0.765 rs10896304 chr11:67981714 T/G cg16338278 chr11:67432957 ALDH3B2 0.44 5.36 0.31 1.83e-7 Breast cancer in childhood cancer survivors;IgG glycosylation; CESC cis rs950776 0.518 rs11630349 chr15:78824608 C/T cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs568617 0.953 rs645900 chr11:65648135 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.69 -7.4 -0.41 1.81e-12 Crohn's disease; CESC cis rs9768139 0.935 rs6953748 chr7:158121184 G/A cg06219351 chr7:158114137 PTPRN2 0.48 7.55 0.42 7.25e-13 Calcium levels; CESC cis rs10463316 0.894 rs13357969 chr5:150751557 A/G cg03212797 chr5:150827313 SLC36A1 -0.53 -6.76 -0.38 8.77e-11 Metabolite levels (Pyroglutamine); CESC cis rs12142240 0.698 rs72677594 chr1:46824371 A/C cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04800682 chr3:58223165 ABHD6 0.44 6.26 0.36 1.55e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3008870 0.755 rs10789219 chr1:67417742 A/C cg02640540 chr1:67518911 SLC35D1 0.46 5.56 0.32 6.52e-8 Lymphocyte percentage of white cells; CESC cis rs2072499 0.868 rs2758600 chr1:156195205 C/T cg25208724 chr1:156163844 SLC25A44 0.94 14.92 0.68 6.04e-37 Testicular germ cell tumor; CESC cis rs7605827 0.930 rs7577130 chr2:15527859 G/A cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 4.04e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9894429 0.738 rs8077038 chr17:79577127 T/G cg18240062 chr17:79603768 NPLOC4 -0.89 -13.21 -0.63 6.03e-31 Eye color traits; CESC cis rs1707322 0.721 rs4330955 chr1:46217485 G/C cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg19163074 chr7:65112434 INTS4L2 0.4 5.08 0.3 7.16e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14387153 chr12:121877053 KDM2B 0.49 6.3 0.36 1.23e-9 Fibrinogen levels; CESC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs7808935 0.768 rs757137 chr7:27989343 T/C cg05786569 chr7:27702416 HIBADH 0.44 5.52 0.32 8.23e-8 Prostate cancer; CESC trans rs208515 0.556 rs1872309 chr6:66660432 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.75 8.67 0.47 4.26e-16 Exhaled nitric oxide levels; CESC cis rs7561273 0.586 rs7580772 chr2:24357657 T/C cg20701182 chr2:24300061 SF3B14 0.46 6.01 0.35 6.27e-9 Quantitative traits; CESC cis rs2404602 0.647 rs11072626 chr15:77090826 A/G cg23625390 chr15:77176239 SCAPER -0.45 -6.04 -0.35 5.17e-9 Blood metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25043602 chr13:113489734 ATP11A 0.54 7.08 0.4 1.29e-11 Fibrinogen levels; CESC cis rs2274273 0.901 rs8011288 chr14:55735112 C/T cg04306507 chr14:55594613 LGALS3 0.3 5.96 0.34 8.08e-9 Protein biomarker; CESC cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg05585544 chr11:47624801 NA -0.47 -6.81 -0.39 6.45e-11 Subjective well-being; CESC cis rs2243480 0.711 rs1626926 chr7:65435792 C/T cg25894440 chr7:65020034 NA -0.63 -5.61 -0.33 5.13e-8 Diabetic kidney disease; CESC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg11494091 chr17:61959527 GH2 -0.72 -11.75 -0.59 6.32e-26 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04250904 chr19:12623422 ZNF709 -0.62 -7.38 -0.41 2.04e-12 Gut microbiome composition (summer); CESC cis rs9487051 0.676 rs2884013 chr6:109599952 C/T cg01475377 chr6:109611718 NA -0.43 -6.82 -0.39 6.19e-11 Reticulocyte fraction of red cells; CESC cis rs9858542 0.953 rs11715915 chr3:49455330 A/G cg07274523 chr3:49395745 GPX1 -0.65 -7.62 -0.42 4.46e-13 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs897984 0.721 rs2305884 chr16:30970741 G/A cg02466173 chr16:30829666 NA 0.47 7.92 0.44 6.36e-14 Dementia with Lewy bodies; CESC cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.86 7.51 0.42 9.05e-13 Initial pursuit acceleration; CESC cis rs6570726 0.905 rs419575 chr6:145840174 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.74 0.38 1e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg07936489 chr17:37558343 FBXL20 0.81 11.85 0.59 2.8e-26 Glomerular filtration rate (creatinine); CESC cis rs853679 0.882 rs9380064 chr6:28143118 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.79 6.91 0.39 3.68e-11 Depression; CESC cis rs12136530 0.593 rs34873850 chr1:19723310 T/C cg01832549 chr1:19774989 CAPZB -0.47 -6.34 -0.36 9.79e-10 Lead levels in blood; CESC trans rs7178375 1.000 rs7178533 chr15:31215976 C/G cg04373760 chr16:53404718 NA 0.53 7.03 0.4 1.76e-11 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21809257 chr1:154955635 FLAD1 0.6 6.31 0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs5769765 0.865 rs9616369 chr22:50304591 A/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.48 -5.44 -0.32 1.2e-7 Schizophrenia; CESC cis rs3796619 1.000 rs2290409 chr4:1067249 C/T cg27284194 chr4:1044797 NA -0.36 -5.49 -0.32 9.61e-8 Recombination rate (males); CESC cis rs7216064 0.906 rs8074644 chr17:65878217 G/C cg07042672 chr17:66097459 LOC651250 -0.57 -6.54 -0.37 3.09e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9859260 0.710 rs41298097 chr3:195779155 C/T cg12923728 chr3:195709715 SDHAP1 0.54 6.96 0.39 2.68e-11 Mean corpuscular volume; CESC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.09 19.22 0.76 3.69e-52 Height; CESC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg22920501 chr2:26401640 FAM59B -0.68 -7.82 -0.43 1.22e-13 Gut microbiome composition (summer); CESC cis rs6500602 0.647 rs1684600 chr16:4594671 C/T cg08645402 chr16:4508243 NA -0.42 -6.45 -0.37 5.18e-10 Schizophrenia; CESC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.56 0.37 2.76e-10 Bipolar disorder; CESC cis rs9905704 0.671 rs2531733 chr17:56548811 A/G cg12560992 chr17:57184187 TRIM37 -0.63 -5.75 -0.33 2.48e-8 Testicular germ cell tumor; CESC cis rs11098499 0.954 rs17009122 chr4:120362403 G/A cg09307838 chr4:120376055 NA 0.94 13.69 0.64 1.22e-32 Corneal astigmatism; CESC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg07507251 chr3:52567010 NT5DC2 0.35 5.94 0.34 8.7e-9 Intelligence (multi-trait analysis); CESC cis rs34779708 0.966 rs113170867 chr10:35450147 C/T cg03585969 chr10:35415529 CREM 0.77 10.27 0.53 4.69e-21 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05588757 chr2:95825608 ZNF514 0.55 6.57 0.37 2.65e-10 Gut microbiome composition (summer); CESC trans rs7615952 0.599 rs1875683 chr3:125732481 C/G cg07211511 chr3:129823064 LOC729375 -0.55 -6.25 -0.36 1.63e-9 Blood pressure (smoking interaction); CESC cis rs524023 0.958 rs3825016 chr11:64359286 C/T cg07220939 chr11:64358617 SLC22A12 -0.35 -5.46 -0.32 1.09e-7 Urate levels in obese individuals; CESC cis rs7078219 0.523 rs4129134 chr10:101284345 C/G cg09788492 chr10:101292477 NKX2-3 0.34 6.45 0.37 5.32e-10 Dental caries; CESC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg07701084 chr6:150067640 NUP43 0.48 6.85 0.39 5.03e-11 Lung cancer; CESC cis rs6545883 0.859 rs35760550 chr2:61603865 T/A cg15711740 chr2:61764176 XPO1 0.4 5.1 0.3 6.53e-7 Tuberculosis; CESC cis rs35110281 0.744 rs230644 chr21:44917183 C/T cg21573476 chr21:45109991 RRP1B 0.4 5.61 0.33 5.2100000000000003e-08 Mean corpuscular volume; CESC cis rs854765 0.724 rs2955371 chr17:17967397 G/A cg16928487 chr17:17741425 SREBF1 0.58 9.93 0.52 5.95e-20 Total body bone mineral density; CESC cis rs34734847 1.000 rs3021338 chr12:121162989 A/G cg21892295 chr12:121157589 UNC119B -0.42 -6.67 -0.38 1.46e-10 Mean corpuscular volume; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg20600338 chr14:71786811 NA 0.46 6.07 0.35 4.48e-9 Tetralogy of Fallot; CESC cis rs113835537 0.529 rs4930183 chr11:66255732 C/T cg22134325 chr11:66188745 NPAS4 0.35 5.48 0.32 1.01e-7 Airway imaging phenotypes; CESC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg07701084 chr6:150067640 NUP43 0.45 6.27 0.36 1.45e-9 Lung cancer; CESC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg23982607 chr1:1823379 GNB1 -0.8 -13.02 -0.62 2.74e-30 Body mass index; CESC cis rs7191439 0.674 rs4782429 chr16:88792097 A/G cg27087555 chr16:88793112 FAM38A -1.35 -12.9 -0.62 7.06e-30 Plateletcrit; CESC cis rs9300255 0.569 rs1727320 chr12:123700476 T/A cg19016782 chr12:123741754 C12orf65 -0.45 -6.5 -0.37 3.89e-10 Neutrophil percentage of white cells; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01953119 chr2:20425340 SDC1 0.48 6.5 0.37 3.94e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.62 0.38 1.98e-10 Bipolar disorder; CESC cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg03213289 chr20:61660250 NA 0.39 6.16 0.35 2.7e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs4756846 1.000 rs72873303 chr11:16473612 G/A cg05579622 chr5:10618622 ANKRD33B 0.71 6.21 0.36 2.01e-9 Obesity and osteoporosis; CESC cis rs7586879 0.520 rs6718511 chr2:25122324 A/G cg01884057 chr2:25150051 NA 0.36 6.99 0.39 2.18e-11 Body mass index; CESC cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.47 7.57 0.42 6.19e-13 Hemoglobin concentration; CESC cis rs7937682 1.000 rs7937682 chr11:111579939 C/G cg09085632 chr11:111637200 PPP2R1B -1.01 -14.47 -0.66 2.3e-35 Primary sclerosing cholangitis; CESC cis rs9611565 0.918 rs7290404 chr22:41749796 C/T cg06634786 chr22:41940651 POLR3H -0.66 -6.94 -0.39 2.99e-11 Vitiligo; CESC cis rs1790761 0.806 rs11601325 chr11:67227006 G/A cg14500267 chr11:67383377 NA -0.31 -5.12 -0.3 5.83e-7 Mean corpuscular volume; CESC cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.05 0.3 8.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.33 5.39 0.31 1.57e-7 Monocyte percentage of white cells; CESC cis rs4076764 0.958 rs6691127 chr1:163384831 T/C cg24596788 chr1:163392923 NA -0.5 -7.34 -0.41 2.55e-12 Motion sickness; CESC cis rs4423214 0.840 rs1792227 chr11:71177412 A/G cg05163923 chr11:71159392 DHCR7 -0.65 -7.55 -0.42 6.91e-13 Vitamin D levels; CESC cis rs116095464 0.558 rs9312956 chr5:201812 T/C cg16372103 chr5:203701 NA 0.51 5.7 0.33 3.12e-8 Breast cancer; CESC cis rs34779708 0.931 rs13376871 chr10:35369056 A/G cg03585969 chr10:35415529 CREM 0.76 10.13 0.53 1.37e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6582630 0.538 rs12304844 chr12:38335870 C/T cg26384229 chr12:38710491 ALG10B -0.41 -5.33 -0.31 2.09e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs910316 0.763 rs175044 chr14:75472109 G/A cg08847533 chr14:75593920 NEK9 -0.86 -14.16 -0.66 2.82e-34 Height; CESC cis rs6732160 0.932 rs6546802 chr2:73379564 G/A cg01422370 chr2:73384389 NA 0.51 8.77 0.47 2.15e-16 Intelligence (multi-trait analysis); CESC cis rs1215050 0.791 rs783960 chr4:98893437 A/G cg05340658 chr4:99064831 C4orf37 -0.51 -6.68 -0.38 1.41e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg18876405 chr7:65276391 NA -0.53 -7.22 -0.41 5.6e-12 Aortic root size; CESC cis rs80130819 0.688 rs1552551 chr12:48643101 C/A cg05342945 chr12:48394962 COL2A1 -0.48 -5.24 -0.31 3.36e-7 Prostate cancer; CESC trans rs60380162 0.963 rs4561014 chr1:87725168 T/C cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.03 -0.35 5.48e-9 Loneliness (linear analysis); CESC cis rs11785400 0.793 rs4567014 chr8:143737690 G/C cg24634471 chr8:143751801 JRK 0.46 5.91 0.34 1.06e-8 Schizophrenia; CESC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg11764359 chr7:65958608 NA -0.53 -6.98 -0.39 2.34e-11 Aortic root size; CESC cis rs17376456 0.809 rs12152763 chr5:93405509 T/A cg21475434 chr5:93447410 FAM172A 0.87 7.47 0.42 1.17e-12 Diabetic retinopathy; CESC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg04756594 chr16:24857601 SLC5A11 0.44 5.3 0.31 2.42e-7 Intelligence (multi-trait analysis); CESC cis rs36051895 0.603 rs1590804 chr9:5177573 T/C cg02405213 chr9:5042618 JAK2 -0.51 -6.62 -0.38 2.03e-10 Pediatric autoimmune diseases; CESC cis rs9929218 0.953 rs12920562 chr16:68737512 C/T cg02972257 chr16:68554789 NA 0.58 6.49 0.37 4.18e-10 Colorectal cancer; CESC trans rs1545843 0.539 rs10862855 chr12:84773682 G/C cg03015433 chr16:56623111 MT3 -0.33 -6.0 -0.35 6.34e-9 Major depressive disorder; CESC cis rs11809207 0.568 rs1892494 chr1:26497626 C/G cg00147160 chr1:26503991 CNKSR1 0.28 5.28 0.31 2.67e-7 Height; CESC cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.8 -11.92 -0.59 1.66e-26 Menarche (age at onset); CESC cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg27347728 chr4:17578864 LAP3 0.46 5.49 0.32 9.24e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2197308 0.565 rs4123923 chr12:37857684 T/C cg13010199 chr12:38710504 ALG10B 0.52 6.63 0.38 1.86e-10 Morning vs. evening chronotype; CESC trans rs4925114 0.568 rs4925109 chr17:17661802 A/G cg21853989 chr1:45804726 MUTYH;TOE1 -0.49 -6.65 -0.38 1.71e-10 Body mass index; CESC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.46 6.4 0.37 6.98e-10 Menopause (age at onset); CESC cis rs2963155 0.518 rs2918419 chr5:142722353 T/C cg17617527 chr5:142782415 NR3C1 0.82 7.8 0.43 1.42e-13 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21830805 chr14:91087524 TTC7B -0.62 -7.33 -0.41 2.87e-12 Gut microbiome composition (summer); CESC cis rs7633770 0.769 rs2385858 chr3:46660436 T/C cg11219411 chr3:46661640 NA 0.48 7.86 0.43 9.51e-14 Coronary artery disease; CESC cis rs9911578 1.000 rs1494977 chr17:56863064 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.12 0.3 6.02e-7 Intelligence (multi-trait analysis); CESC cis rs501120 1.000 rs501120 chr10:44753867 T/C cg09554077 chr10:44749378 NA 0.52 6.89 0.39 3.96e-11 Coronary artery disease;Coronary heart disease; CESC cis rs6582630 0.555 rs11182148 chr12:38464883 A/C cg13010199 chr12:38710504 ALG10B 0.43 5.65 0.33 4.08e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12477438 0.520 rs13798 chr2:99813614 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.91 15.7 0.69 1.04e-39 Chronic sinus infection; CESC cis rs9815354 1.000 rs73071329 chr3:41810539 G/A cg03022575 chr3:42003672 ULK4 0.47 5.22 0.31 3.64e-7 Pulse pressure;Diastolic blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19987288 chr12:56122958 CD63 -0.5 -6.72 -0.38 1.13e-10 Fibrinogen levels; CESC trans rs1814175 0.817 rs4881645 chr11:49791168 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.96 -0.77 1.02e-54 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02514855 chr8:100905969 COX6C -0.42 -6.43 -0.37 5.91e-10 Gambling; CESC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg25036284 chr2:26402008 FAM59B -0.59 -6.88 -0.39 4.37e-11 Gut microbiome composition (summer); CESC cis rs7267979 0.966 rs2145126 chr20:25263648 G/A cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.08e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2180341 1.000 rs13218061 chr6:127653758 G/A cg27446573 chr6:127587934 RNF146 1.09 16.35 0.71 5.12e-42 Breast cancer; CESC cis rs75920871 0.502 rs10790166 chr11:116779499 A/G cg19396677 chr11:116643857 BUD13 0.41 5.17 0.3 4.59e-7 Subjective well-being; CESC cis rs897080 0.515 rs2850290 chr2:44636055 A/G cg04920474 chr2:44395004 PPM1B 0.37 5.03 0.3 9.22e-7 Height; CESC cis rs34172651 0.917 rs7204281 chr16:24784475 C/T cg06028605 chr16:24865363 SLC5A11 0.41 6.13 0.35 3.26e-9 Intelligence (multi-trait analysis); CESC cis rs9611565 0.559 rs6002408 chr22:41967870 C/T cg03806693 chr22:41940476 POLR3H -0.98 -11.78 -0.59 4.85e-26 Vitiligo; CESC cis rs599083 0.530 rs2472415 chr11:68185616 T/C cg16797656 chr11:68205561 LRP5 -0.39 -5.18 -0.3 4.48e-7 Bone mineral density (spine); CESC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg09365446 chr1:150670422 GOLPH3L 0.38 5.13 0.3 5.74e-7 Melanoma; CESC cis rs7212590 0.581 rs8064505 chr17:57838831 G/A cg20303301 chr17:57937339 TUBD1 -0.55 -5.18 -0.3 4.34e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs7208859 0.673 rs2269915 chr17:29233344 C/T cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg17366294 chr4:99064904 C4orf37 0.6 8.44 0.46 2.12e-15 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg14926445 chr8:58193284 C8orf71 -0.5 -5.4 -0.31 1.49e-7 Developmental language disorder (linguistic errors); CESC trans rs877282 0.700 rs816311 chr10:796490 C/A cg22713356 chr15:30763199 NA 1.1 11.92 0.59 1.59e-26 Uric acid levels; CESC cis rs634534 0.561 rs14157 chr11:65769780 T/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.75 10.97 0.56 2.48e-23 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs2014572 0.967 rs10413037 chr19:57771883 A/G cg12963866 chr19:57752005 ZNF805 -0.45 -5.93 -0.34 9.64e-9 Hyperactive-impulsive symptoms; CESC cis rs6121246 0.609 rs6060955 chr20:30385071 A/G cg13852791 chr20:30311386 BCL2L1 0.78 9.95 0.52 5.02e-20 Mean corpuscular hemoglobin; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg03762994 chr17:6899332 ALOX12 0.39 6.86 0.39 4.95e-11 Tonsillectomy; CESC cis rs1559088 0.895 rs13345542 chr19:33586739 G/C cg27124370 chr19:33622961 WDR88 0.45 6.0 0.35 6.49e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1881797 0.932 rs41305741 chr1:247689543 A/G cg21399703 chr1:247681439 NA 0.55 7.36 0.41 2.29e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs367615 0.918 rs72797472 chr5:108881343 C/T cg17395555 chr5:108820864 NA 0.57 8.65 0.47 5.12e-16 Colorectal cancer (SNP x SNP interaction); CESC cis rs6456156 0.583 rs7748224 chr6:167456860 C/T cg07741184 chr6:167504864 NA 0.34 5.73 0.33 2.68e-8 Primary biliary cholangitis; CESC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg09781414 chr16:715207 WDR90 -0.33 -5.03 -0.3 9.04e-7 Height; CESC cis rs2074585 0.802 rs2589940 chr15:90931363 C/T cg10434728 chr15:90938212 IQGAP1 0.42 7.69 0.43 2.9e-13 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27051224 chr16:2113170 TSC2 0.42 6.12 0.35 3.28e-9 Fibrinogen levels; CESC cis rs7833986 0.501 rs2953911 chr8:56948009 G/A cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.16 0.3 4.9e-7 Height; CESC cis rs123509 0.687 rs73077220 chr3:42842340 T/C cg12982090 chr3:42733453 KBTBD5 -0.66 -7.52 -0.42 8.26e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg18876405 chr7:65276391 NA 0.5 6.87 0.39 4.63e-11 Aortic root size; CESC cis rs7216064 0.953 rs12450907 chr17:65870644 T/G cg07042672 chr17:66097459 LOC651250 -0.54 -5.59 -0.32 5.61e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10979 1.000 rs7774497 chr6:143889033 T/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs9896052 0.572 rs4078474 chr17:73489567 C/G cg25649188 chr17:73499917 CASKIN2 0.36 5.27 0.31 2.77e-7 Sight-threatening diabetic retinopathy in type 2 diabetes; CESC cis rs6580649 0.771 rs1635535 chr12:48386241 A/G cg05342945 chr12:48394962 COL2A1 -0.51 -6.1 -0.35 3.71e-9 Lung cancer; CESC cis rs2735413 0.564 rs4324138 chr16:78101372 A/C cg04733911 chr16:78082701 NA 0.41 5.17 0.3 4.71e-7 Systolic blood pressure (alcohol consumption interaction); CESC cis rs4253772 0.530 rs11090875 chr22:46785301 C/T cg24881330 chr22:46731750 TRMU 0.77 5.44 0.32 1.21e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7635838 0.653 rs2606749 chr3:11373635 A/G cg00170343 chr3:11313890 ATG7 0.54 7.79 0.43 1.5700000000000001e-13 HDL cholesterol; CESC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs7084402 0.935 rs12248958 chr10:60278255 G/A cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC cis rs16854884 0.586 rs13081286 chr3:143723757 A/T cg01302019 chr3:143689584 C3orf58 -0.33 -5.12 -0.3 5.87e-7 Economic and political preferences (feminism/equality); CESC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg00750074 chr16:89608354 SPG7 -0.38 -5.3 -0.31 2.47e-7 Multiple myeloma (IgH translocation); CESC cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.76 11.14 0.56 6.75e-24 Monocyte percentage of white cells; CESC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg05861140 chr6:150128134 PCMT1 0.37 5.3 0.31 2.5e-7 Lung cancer; CESC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg21747405 chr11:67723411 NA -0.42 -6.66 -0.38 1.53e-10 Blood pressure (smoking interaction); CESC trans rs116095464 0.558 rs60251075 chr5:245292 T/C cg00938859 chr5:1591904 SDHAP3 0.64 6.98 0.39 2.36e-11 Breast cancer; CESC trans rs4332037 0.624 rs73046339 chr7:1889300 G/A cg11693508 chr17:37793320 STARD3 0.6 6.12 0.35 3.27e-9 Bipolar disorder; CESC cis rs2228479 0.850 rs2238527 chr16:89840708 C/A cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs6582630 0.555 rs12372536 chr12:38400864 C/G cg13010199 chr12:38710504 ALG10B 0.48 6.21 0.36 2.03e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7607369 0.559 rs4674342 chr2:219660064 T/C cg02176678 chr2:219576539 TTLL4 -0.4 -7.1 -0.4 1.18e-11 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg05215272 chr17:6899095 ALOX12 0.42 7.91 0.44 6.93e-14 Tonsillectomy; CESC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs4481887 0.888 rs4525076 chr1:248456876 T/G cg00666640 chr1:248458726 OR2T12 0.41 6.8 0.39 6.72e-11 Common traits (Other); CESC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg19046167 chr17:80928561 B3GNTL1 0.46 5.51 0.32 8.54e-8 Glycated hemoglobin levels; CESC trans rs2113818 0.568 rs10197989 chr2:12935982 G/A cg25307771 chr13:91067121 NA 0.43 6.2 0.36 2.18e-9 Optic cup area; CESC cis rs11190604 1.000 rs11190557 chr10:102209369 G/A cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs2635047 0.638 rs2668758 chr18:44685679 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.71 0.33 3.01e-8 Educational attainment; CESC cis rs7772486 0.686 rs702314 chr6:146003510 G/A cg05347473 chr6:146136440 FBXO30 -0.52 -6.84 -0.39 5.3e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs10752881 0.967 rs6695837 chr1:182991462 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.31 0.63 2.66e-31 Colorectal cancer; CESC cis rs2011503 1.000 rs11670882 chr19:19649748 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.54 5.77 0.33 2.16e-8 Bipolar disorder; CESC cis rs9388451 0.626 rs1268074 chr6:126107791 G/C cg05901451 chr6:126070800 HEY2 -0.57 -8.24 -0.45 7.96e-15 Brugada syndrome; CESC cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg26597838 chr10:835615 NA 0.87 9.13 0.49 1.86e-17 Eosinophil percentage of granulocytes; CESC cis rs9611565 0.681 rs6002372 chr22:41801299 A/T cg06481639 chr22:41940642 POLR3H 0.64 6.56 0.37 2.82e-10 Vitiligo; CESC cis rs12950390 0.893 rs4239165 chr17:45847272 A/T cg00777063 chr17:45855553 NA -0.41 -6.14 -0.35 3.03e-9 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23176496 chr8:67687356 SGK3 0.54 6.11 0.35 3.61e-9 Gut microbiome composition (summer); CESC cis rs2985684 0.748 rs2985686 chr14:50100683 C/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.45 -5.06 -0.3 7.89e-7 Carotid intima media thickness; CESC cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg23711669 chr6:146136114 FBXO30 -0.94 -12.0 -0.59 8.66e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg03351412 chr1:154909251 PMVK 0.64 8.72 0.47 3.02e-16 Prostate cancer; CESC cis rs2832077 0.527 rs2832116 chr21:30228368 C/A cg24692254 chr21:30365293 RNF160 -0.66 -9.15 -0.49 1.56e-17 Cognitive test performance; CESC cis rs1878931 0.624 rs27241 chr16:3447282 C/G cg02880119 chr16:3481970 NA 0.44 5.46 0.32 1.11e-7 Body mass index (adult); CESC cis rs6502050 0.842 rs7211808 chr17:80071244 T/C cg11859384 chr17:80120422 CCDC57 0.38 5.22 0.31 3.54e-7 Life satisfaction; CESC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg11890956 chr21:40555474 PSMG1 -0.94 -15.27 -0.68 3.31e-38 Cognitive function; CESC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg19901468 chr14:105411992 AHNAK2 -0.6 -8.69 -0.47 3.74e-16 Rheumatoid arthritis; CESC cis rs477692 0.875 rs7091540 chr10:131420276 C/T cg05714579 chr10:131428358 MGMT -0.55 -7.85 -0.43 1.05e-13 Response to temozolomide; CESC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg07395648 chr5:131743802 NA -0.42 -5.4 -0.31 1.49e-7 Breast cancer;Mosquito bite size; CESC cis rs2204008 0.623 rs4882302 chr12:38415608 T/A cg26384229 chr12:38710491 ALG10B -0.44 -5.99 -0.35 6.77e-9 Bladder cancer; CESC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg04287289 chr16:89883240 FANCA 0.88 15.5 0.69 5.35e-39 Vitiligo; CESC cis rs7917772 0.582 rs10786698 chr10:104378750 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.38 5.23 0.31 3.38e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs6700559 0.810 rs7521550 chr1:200592363 C/G cg05185519 chr16:2972941 FLYWCH1 -0.48 -6.22 -0.36 1.89e-9 Coronary artery disease; CESC cis rs708547 0.676 rs11133470 chr4:57864926 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.59 8.74 0.47 2.79e-16 Response to bleomycin (chromatid breaks); CESC cis rs911555 0.723 rs11160751 chr14:103925740 T/C cg09975044 chr14:104007538 NA 0.45 5.59 0.32 5.7e-8 Intelligence (multi-trait analysis); CESC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg25036284 chr2:26402008 FAM59B 0.6 6.86 0.39 4.74e-11 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.44 0.81 3.19e-63 Prudent dietary pattern; CESC cis rs2439831 1.000 rs2254321 chr15:43707542 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.86 10.53 0.54 6.86e-22 Lung cancer in ever smokers; CESC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg23281280 chr6:28129359 ZNF389 0.59 7.91 0.44 6.86e-14 Depression; CESC cis rs6088590 0.582 rs6059909 chr20:33139691 C/A cg06115741 chr20:33292138 TP53INP2 0.5 6.39 0.37 7.53e-10 Coronary artery disease; CESC cis rs2075371 0.501 rs1643057 chr7:134027521 A/G cg20476274 chr7:133979776 SLC35B4 0.42 5.36 0.31 1.8e-7 Mean platelet volume; CESC cis rs11577318 0.853 rs3795684 chr1:26632781 C/T cg00852783 chr1:26633632 UBXN11 0.51 7.16 0.4 8.01e-12 Granulocyte percentage of myeloid white cells; CESC cis rs7927592 0.913 rs2236708 chr11:68378045 G/A cg20283391 chr11:68216788 NA -0.6 -7.23 -0.41 5.28e-12 Total body bone mineral density; CESC cis rs67311347 1.000 rs4973898 chr3:40459532 A/G cg24209194 chr3:40518798 ZNF619 -0.5 -6.69 -0.38 1.34e-10 Renal cell carcinoma; CESC cis rs9325144 0.600 rs7312522 chr12:38730423 A/G cg26384229 chr12:38710491 ALG10B 0.56 8.06 0.44 2.62e-14 Morning vs. evening chronotype; CESC cis rs6831352 0.918 rs7689753 chr4:100055575 A/G cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg16325326 chr1:53192061 ZYG11B -0.88 -15.06 -0.68 1.8e-37 Monocyte count; CESC cis rs7662987 0.517 rs2851268 chr4:100027878 A/G cg12011299 chr4:100065546 ADH4 0.6 6.6 0.38 2.23e-10 Smoking initiation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05994508 chr17:78518873 RPTOR -0.42 -6.09 -0.35 3.89e-9 Gambling; CESC cis rs637571 0.607 rs589253 chr11:65693080 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 9.97 0.52 4.4e-20 Eosinophil percentage of white cells; CESC cis rs6088590 1.000 rs6087625 chr20:33342477 A/G cg08999081 chr20:33150536 PIGU -0.59 -9.05 -0.49 3.07e-17 Coronary artery disease; CESC cis rs7179456 0.547 rs6494036 chr15:59015961 A/T cg05156742 chr15:59063176 FAM63B 0.59 7.44 0.42 1.43e-12 Asperger disorder; CESC cis rs7666738 0.830 rs28878289 chr4:98855181 C/T cg17366294 chr4:99064904 C4orf37 0.55 7.72 0.43 2.38e-13 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03205495 chr19:14640249 TECR;MIR639 0.5 6.34 0.36 9.7e-10 Gut microbiota (bacterial taxa); CESC cis rs11690935 0.589 rs2271758 chr2:172701157 T/G cg13550731 chr2:172543902 DYNC1I2 0.52 7.02 0.4 1.83e-11 Schizophrenia; CESC trans rs1728785 1.000 rs1645928 chr16:68590610 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.68 8.06 0.44 2.62e-14 Ulcerative colitis; CESC cis rs8114671 0.562 rs6088621 chr20:33418740 C/T cg24642439 chr20:33292090 TP53INP2 0.47 5.64 0.33 4.3e-8 Height; CESC cis rs17376456 0.877 rs114256265 chr5:93473130 T/A cg21475434 chr5:93447410 FAM172A 0.86 7.66 0.43 3.53e-13 Diabetic retinopathy; CESC cis rs9549367 0.713 rs2476319 chr13:113836519 C/T cg00898013 chr13:113819073 PROZ 0.46 6.9 0.39 3.73e-11 Platelet distribution width; CESC cis rs2730245 0.527 rs712197 chr7:158660846 C/G cg24397884 chr7:158709396 WDR60 0.81 8.15 0.45 1.41e-14 Height; CESC cis rs4595586 0.545 rs2218762 chr12:39397762 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02205746 chr16:2732724 KCTD5 0.61 7.4 0.41 1.8e-12 Gut microbiome composition (summer); CESC cis rs2415984 0.558 rs10220566 chr14:46965511 A/T cg14871534 chr14:47121158 RPL10L -0.35 -5.22 -0.31 3.56e-7 Number of children ever born; CESC cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs61776719 0.520 rs72661887 chr1:38416310 C/T cg18451016 chr1:38461880 NA 0.4 5.96 0.34 8.05e-9 Coronary artery disease; CESC cis rs847577 0.630 rs13221758 chr7:97719806 A/C cg21770322 chr7:97807741 LMTK2 0.86 15.7 0.69 1e-39 Breast cancer; CESC trans rs7980799 0.618 rs1482983 chr12:33690326 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.65 0.43 3.72e-13 Heart rate;Heart rate variability traits (RMSSD); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16492828 chr12:100567203 GOLGA2L1 0.54 6.26 0.36 1.57e-9 Ulcerative colitis; CESC cis rs80282103 0.618 rs56004802 chr10:1159187 C/T cg08668510 chr10:1095578 IDI1 0.74 6.02 0.35 5.95e-9 Glomerular filtration rate (creatinine); CESC cis rs8016982 0.651 rs9806027 chr14:81668707 G/C cg01989461 chr14:81687754 GTF2A1 0.69 10.23 0.53 6.34e-21 Schizophrenia; CESC cis rs2011503 0.883 rs17216041 chr19:19366643 C/T cg11584989 chr19:19387371 SF4 0.57 6.74 0.38 9.87e-11 Bipolar disorder; CESC cis rs763121 0.853 rs8140617 chr22:38970439 A/G cg06022373 chr22:39101656 GTPBP1 -0.76 -10.15 -0.53 1.12e-20 Menopause (age at onset); CESC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 2.94e-12 Developmental language disorder (linguistic errors); CESC cis rs7949030 0.588 rs2509961 chr11:62310909 T/C cg22862634 chr11:62369728 EML3;MTA2 0.49 6.83 0.39 5.97e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20189904 chr20:35974307 SRC 0.58 7.19 0.4 6.49e-12 Gut microbiome composition (summer); CESC cis rs2228479 0.541 rs9922515 chr16:89954138 G/C cg00800038 chr16:89945340 TCF25 -0.64 -7.16 -0.4 7.77e-12 Skin colour saturation; CESC cis rs3125734 0.671 rs3852406 chr10:64015162 T/C cg09941381 chr10:64027924 RTKN2 -0.32 -5.21 -0.3 3.79e-7 Rheumatoid arthritis; CESC cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg13628971 chr7:2884303 GNA12 0.4 5.21 0.3 3.81e-7 Height; CESC cis rs6714710 0.603 rs13020776 chr2:98402753 T/A cg26665480 chr2:98280029 ACTR1B 0.57 8.03 0.44 3.3e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg08847533 chr14:75593920 NEK9 -1.0 -18.49 -0.75 1.41e-49 Height; CESC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg02725872 chr8:58115012 NA -0.38 -5.13 -0.3 5.73e-7 Developmental language disorder (linguistic errors); CESC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Tonsillectomy; CESC cis rs9512730 0.553 rs6491213 chr13:28049822 T/C cg08193333 chr13:27998609 GTF3A 0.46 5.53 0.32 7.86e-8 Schizophrenia; CESC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg14061069 chr19:46274453 DMPK 0.52 8.23 0.45 8.79e-15 Coronary artery disease; CESC cis rs6570726 0.935 rs379164 chr6:145829093 A/T cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1670533 0.932 rs11731289 chr4:1057773 T/G cg04106633 chr4:1044584 NA 0.41 5.19 0.3 4.11e-7 Recombination rate (females); CESC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg19193384 chr17:30244184 NA 0.49 5.1 0.3 6.47e-7 Hip circumference adjusted for BMI; CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg25934064 chr3:52569026 NT5DC2 0.26 5.55 0.32 6.85e-8 Bipolar disorder; CESC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg17971929 chr21:40555470 PSMG1 0.94 12.52 0.61 1.42e-28 Cognitive function; CESC cis rs5167 0.504 rs7248162 chr19:45454686 T/C cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.23e-14 Blood protein levels; CESC cis rs6690583 0.562 rs11588919 chr1:85442813 A/T cg22488158 chr1:85528044 WDR63 0.55 5.1 0.3 6.48e-7 Serum sulfate level; CESC cis rs863345 0.604 rs11264984 chr1:158464990 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12941161 chr10:112290002 NA 0.49 7.22 0.41 5.63e-12 Systemic lupus erythematosus; CESC cis rs8014204 0.544 rs2286913 chr14:75386576 G/A cg08847533 chr14:75593920 NEK9 0.6 7.46 0.42 1.22e-12 Caffeine consumption; CESC cis rs72945132 1.000 rs72945132 chr11:70113901 G/C cg14191688 chr11:70257035 CTTN 0.43 5.15 0.3 5.06e-7 Coronary artery disease; CESC trans rs7070678 0.905 rs2368394 chr10:29811059 A/G cg06477056 chr5:175110609 HRH2 0.36 6.79 0.38 7.17e-11 Platelet thrombus formation; CESC cis rs1256061 0.603 rs10148269 chr14:64736924 A/G cg23250157 chr14:64679961 SYNE2 0.53 7.64 0.42 4.09e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs295137 0.798 rs295142 chr2:201211716 C/T cg23649088 chr2:200775458 C2orf69 -0.47 -6.19 -0.36 2.26e-9 Asthma (bronchodilator response); CESC cis rs6540556 0.723 rs9430014 chr1:209905372 A/C cg05527609 chr1:210001259 C1orf107 -0.6 -6.58 -0.37 2.49e-10 Red blood cell count; CESC cis rs7301826 0.651 rs12228957 chr12:131296066 T/C cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg04518342 chr5:131593106 PDLIM4 0.4 5.96 0.34 7.99e-9 Acylcarnitine levels; CESC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg22800045 chr5:56110881 MAP3K1 0.81 9.96 0.52 4.75e-20 Initial pursuit acceleration; CESC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg02574844 chr11:5959923 NA -0.48 -6.9 -0.39 3.79e-11 DNA methylation (variation); CESC cis rs34779708 0.931 rs55724039 chr10:35465397 A/G cg03585969 chr10:35415529 CREM 0.77 10.34 0.54 2.94e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs3741151 0.686 rs1938777 chr11:73122340 A/G cg17517138 chr11:73019481 ARHGEF17 0.66 5.64 0.33 4.45e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs6780666 0.509 rs972585 chr3:136954106 G/T cg16900796 chr19:10755136 SLC44A2 -0.43 -6.51 -0.37 3.73e-10 Intelligence (multi-trait analysis); CESC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.97 -0.52 4.38e-20 Developmental language disorder (linguistic errors); CESC cis rs4664304 0.770 rs55860731 chr2:160875437 C/T cg03641300 chr2:160917029 PLA2R1 -0.5 -7.09 -0.4 1.19e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs965469 1.000 rs2236117 chr20:3302021 T/C cg25506879 chr20:3388711 C20orf194 -0.56 -6.08 -0.35 4.16e-9 IFN-related cytopenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17963944 chr7:100303258 POP7 -0.49 -6.52 -0.37 3.44e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4919694 1.000 rs11191490 chr10:104745174 T/A cg04362960 chr10:104952993 NT5C2 0.74 6.45 0.37 5.32e-10 Arsenic metabolism; CESC cis rs35570576 0.585 rs35796193 chr17:77537418 A/G cg05749138 chr17:77536956 NA 0.38 5.29 0.31 2.58e-7 Photic sneeze reflex; CESC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg23281280 chr6:28129359 ZNF389 0.5 6.56 0.37 2.75e-10 Parkinson's disease; CESC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg17724175 chr1:150552817 MCL1 0.46 7.55 0.42 6.93e-13 Melanoma; CESC cis rs2243480 1.000 rs2462569 chr7:65474846 C/T cg12463550 chr7:65579703 CRCP -0.71 -5.96 -0.34 7.88e-9 Diabetic kidney disease; CESC trans rs17685 0.753 rs6464999 chr7:75787315 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.42 0.61 3.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs10089 1.000 rs10064357 chr5:127417272 A/G cg19767477 chr5:127420684 SLC12A2 -0.41 -5.42 -0.32 1.35e-7 Ileal carcinoids; CESC cis rs16866061 0.515 rs3738951 chr2:225368321 A/G cg12698349 chr2:225449008 CUL3 0.81 14.15 0.66 3.03e-34 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg09359103 chr1:154839909 KCNN3 -0.67 -12.75 -0.62 2.3e-29 Prostate cancer; CESC cis rs698833 0.962 rs1065785 chr2:44660699 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.85 0.34 1.48e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24731015 chr5:70751422 BDP1 -0.56 -6.09 -0.35 4.05e-9 Gut microbiome composition (summer); CESC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg12963246 chr6:28129442 ZNF389 0.49 6.39 0.37 7.29e-10 Parkinson's disease; CESC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg04166393 chr7:2884313 GNA12 0.64 8.43 0.46 2.27e-15 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03159329 chr2:169103514 STK39 -0.42 -6.06 -0.35 4.72e-9 Gambling; CESC cis rs9905704 0.647 rs11659035 chr17:56966052 C/T cg12560992 chr17:57184187 TRIM37 0.62 7.63 0.42 4.12e-13 Testicular germ cell tumor; CESC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg00166722 chr3:10149974 C3orf24 0.55 7.09 0.4 1.21e-11 Alzheimer's disease; CESC cis rs926938 0.543 rs360600 chr1:115388116 T/C cg12756093 chr1:115239321 AMPD1 0.47 6.32 0.36 1.1e-9 Autism; CESC cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg02034447 chr16:89574710 SPG7 -0.4 -5.15 -0.3 4.98e-7 Multiple myeloma (IgH translocation); CESC cis rs6674176 0.660 rs6801 chr1:44396646 C/G cg13606994 chr1:44402422 ARTN 0.43 6.67 0.38 1.53e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg07167872 chr1:205819463 PM20D1 0.42 6.3 0.36 1.24e-9 Prostate cancer; CESC cis rs4604732 0.536 rs61184655 chr1:247651342 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.58 7.63 0.42 4.13e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs55728055 0.661 rs7285091 chr22:31996363 A/G cg01338084 chr22:32026380 PISD 1.22 8.02 0.44 3.48e-14 Age-related hearing impairment; CESC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg07308232 chr7:1071921 C7orf50 -0.61 -8.77 -0.47 2.21e-16 Longevity;Endometriosis; CESC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.01 9.83 0.52 1.21e-19 Platelet count; CESC cis rs11696501 0.694 rs6124722 chr20:44263264 G/A cg11783356 chr20:44313418 WFDC10B -0.34 -5.29 -0.31 2.54e-7 Brain structure; CESC cis rs2370759 1.000 rs11594459 chr10:32561858 A/C cg05361325 chr10:32636312 EPC1 -0.58 -5.15 -0.3 5e-7 Sexual dysfunction (female); CESC cis rs9815354 1.000 rs1717033 chr3:41910216 C/T cg03022575 chr3:42003672 ULK4 0.44 5.13 0.3 5.55e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs10489202 1.000 rs17557135 chr1:167985888 A/G cg24449463 chr1:168025552 DCAF6 -0.46 -5.29 -0.31 2.53e-7 Schizophrenia; CESC cis rs12618769 0.597 rs55934321 chr2:99099417 G/A cg10123293 chr2:99228465 UNC50 0.39 5.14 0.3 5.22e-7 Bipolar disorder; CESC cis rs8180040 0.966 rs11716763 chr3:47518266 C/T cg27129171 chr3:47204927 SETD2 -0.63 -9.49 -0.5 1.38e-18 Colorectal cancer; CESC cis rs1048238 0.506 rs10927867 chr1:16177285 A/G cg22431228 chr1:16359049 CLCNKA -0.36 -6.18 -0.35 2.4e-9 Systolic blood pressure; CESC cis rs977987 0.931 rs11641430 chr16:75495276 T/C cg03315344 chr16:75512273 CHST6 0.54 7.9 0.44 7.62e-14 Dupuytren's disease; CESC cis rs3806843 0.735 rs801180 chr5:140092903 G/T cg26395211 chr5:140044315 WDR55 0.46 5.97 0.34 7.77e-9 Depressive symptoms (multi-trait analysis); CESC cis rs9911578 0.839 rs1871751 chr17:57190368 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.4 5.17 0.3 4.67e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03243700 chr9:137000940 WDR5 -0.59 -6.78 -0.38 7.91e-11 Gut microbiome composition (summer); CESC cis rs4835473 0.897 rs28701142 chr4:144866883 G/A cg25736465 chr4:144833511 NA 0.39 5.99 0.35 6.86e-9 Immature fraction of reticulocytes; CESC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Depression; CESC cis rs9611565 0.840 rs2234052 chr22:41777241 A/G cg06634786 chr22:41940651 POLR3H -0.68 -7.28 -0.41 3.87e-12 Vitiligo; CESC cis rs1568889 0.877 rs1384903 chr11:28124359 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.68 6.86 0.39 4.73e-11 Bipolar disorder; CESC cis rs870825 0.616 rs7680779 chr4:185652830 G/C cg04058563 chr4:185651563 MLF1IP -0.6 -6.93 -0.39 3.28e-11 Blood protein levels; CESC trans rs10820912 0.636 rs4367687 chr9:92886193 C/T cg23943268 chr13:33589621 KL -0.47 -6.03 -0.35 5.55e-9 Left atrial antero-posterior diameter; CESC cis rs7202877 0.572 rs8051611 chr16:75388933 C/T cg04384234 chr16:75411784 CFDP1 -0.49 -5.89 -0.34 1.16e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg10018233 chr7:150070692 REPIN1 0.39 5.38 0.31 1.67e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs4803468 1.000 rs284651 chr19:41928336 T/C cg09537434 chr19:41945824 ATP5SL -1.11 -20.37 -0.78 3.82e-56 Height; CESC cis rs950776 1.000 rs950776 chr15:78926018 A/G cg06917634 chr15:78832804 PSMA4 0.6 6.65 0.38 1.63e-10 Sudden cardiac arrest; CESC cis rs12442242 0.522 rs12901075 chr15:38359137 C/A cg19084031 chr15:38361362 NA 1.06 6.87 0.39 4.54e-11 Total body bone mineral density; CESC trans rs1814175 0.817 rs7481230 chr11:49772235 G/A cg03929089 chr4:120376271 NA -0.9 -14.81 -0.67 1.43e-36 Height; CESC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg27535305 chr1:53392650 SCP2 0.33 5.34 0.31 2.03e-7 Monocyte count; CESC cis rs2635047 0.713 rs9950812 chr18:44765943 G/A cg24371990 chr18:44770781 NA 0.41 6.74 0.38 1e-10 Educational attainment; CESC cis rs8141529 0.588 rs10222249 chr22:29257147 A/G cg15103426 chr22:29168792 CCDC117 0.52 6.39 0.37 7.25e-10 Lymphocyte counts; CESC cis rs12477438 0.798 rs4850894 chr2:99629396 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs4561483 0.583 rs17236573 chr16:11994655 G/C cg08843971 chr16:11963173 GSPT1 0.46 6.41 0.37 6.53e-10 Testicular germ cell tumor; CESC cis rs2549003 1.000 rs2549007 chr5:131826875 T/C cg02551604 chr5:131831745 NA 0.37 5.25 0.31 3.09e-7 Asthma (sex interaction); CESC cis rs1707322 1.000 rs6677777 chr1:46475836 A/G cg03146154 chr1:46216737 IPP 0.79 10.39 0.54 1.98e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg21573476 chr21:45109991 RRP1B -0.5 -6.91 -0.39 3.62e-11 Mean corpuscular volume; CESC cis rs1005277 0.522 rs289648 chr10:37971837 T/C cg25517755 chr10:38738941 LOC399744 -0.43 -5.66 -0.33 3.99e-8 Extrinsic epigenetic age acceleration; CESC cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg10523679 chr1:76189770 ACADM 0.72 8.33 0.46 4.31e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg04051697 chr2:88470813 THNSL2 0.46 6.16 0.35 2.73e-9 Response to metformin (IC50); CESC cis rs4692589 0.802 rs2877501 chr4:170955277 G/T cg19918862 chr4:170955249 NA 0.43 6.63 0.38 1.87e-10 Anxiety disorder; CESC trans rs9929218 0.529 rs11640736 chr16:68738324 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.87 14.04 0.65 7.26e-34 Colorectal cancer; CESC cis rs7692995 1.000 rs1876219 chr4:17961415 G/A cg08925142 chr4:18023851 LCORL -0.45 -5.13 -0.3 5.66e-7 Height; CESC cis rs11864453 0.826 rs6499559 chr16:72132064 G/C cg16558253 chr16:72132732 DHX38 -0.61 -9.65 -0.51 4.5e-19 Fibrinogen levels; CESC cis rs3762637 1.000 rs9833415 chr3:122159840 G/A cg24169773 chr3:122142474 KPNA1 -0.55 -6.47 -0.37 4.76e-10 LDL cholesterol levels; CESC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg27170947 chr2:26402098 FAM59B -0.72 -8.3 -0.45 5.54e-15 Gut microbiome composition (summer); CESC cis rs8077889 0.917 rs58080788 chr17:41902909 A/G cg26893861 chr17:41843967 DUSP3 0.74 9.39 0.5 2.82e-18 Triglycerides; CESC cis rs5747327 0.874 rs3788279 chr22:18200386 G/A cg19898043 chr22:18121309 BCL2L13 -0.4 -5.14 -0.3 5.21e-7 Myeloid white cell count;Granulocyte count; CESC cis rs2816062 0.710 rs2816052 chr1:18895536 T/C cg18795169 chr1:18902165 NA -0.94 -19.04 -0.76 1.61e-51 Urate levels in lean individuals; CESC cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg22834771 chr12:69754056 YEATS4 -0.39 -5.26 -0.31 2.94e-7 Blood protein levels; CESC cis rs6901004 0.803 rs1040903 chr6:111470153 A/C cg15721981 chr6:111408429 SLC16A10 -0.34 -5.09 -0.3 6.78e-7 Blood metabolite levels; CESC trans rs12542260 0.871 rs62527884 chr8:125483344 A/G cg09438698 chr12:133365205 GOLGA3 -0.47 -6.05 -0.35 4.83e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.655 rs3014240 chr1:46089225 C/G cg06784218 chr1:46089804 CCDC17 -0.4 -7.01 -0.4 1.97e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg26314531 chr2:26401878 FAM59B 0.59 6.65 0.38 1.69e-10 Gut microbiome composition (summer); CESC cis rs2795502 0.938 rs3121324 chr10:43379515 C/T cg27426351 chr10:43362370 NA 0.4 5.04 0.3 8.83e-7 Blood protein levels; CESC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg13114125 chr14:105738426 BRF1 -0.78 -10.03 -0.52 2.81e-20 Mean platelet volume;Platelet distribution width; CESC cis rs3806843 1.000 rs2240694 chr5:140183058 G/A cg26395211 chr5:140044315 WDR55 -0.42 -5.35 -0.31 1.9e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg01475377 chr6:109611718 NA -0.49 -8.11 -0.45 1.85e-14 Reticulocyte fraction of red cells; CESC cis rs11785400 0.793 rs4736364 chr8:143742113 C/T cg10596483 chr8:143751796 JRK 0.42 5.42 0.32 1.33e-7 Schizophrenia; CESC cis rs10208940 0.920 rs10205573 chr2:68829419 A/T cg12452813 chr2:68675892 NA 0.54 5.34 0.31 1.98e-7 Urate levels in lean individuals; CESC cis rs2625529 0.730 rs2929528 chr15:72269337 C/A cg16672083 chr15:72433130 SENP8 0.43 6.26 0.36 1.53e-9 Red blood cell count; CESC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg19592336 chr6:28129416 ZNF389 0.52 6.59 0.38 2.37e-10 Depression; CESC cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg23711669 chr6:146136114 FBXO30 -1.04 -14.79 -0.67 1.66e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg00255919 chr5:131827918 IRF1 0.51 8.68 0.47 4.19e-16 Asthma (sex interaction); CESC cis rs1153858 1.000 rs67461176 chr15:45676819 C/T cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs11122272 0.735 rs2491408 chr1:231519248 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs79349575 0.685 rs1124829 chr17:46967797 C/A cg16584676 chr17:46985605 UBE2Z 0.55 6.69 0.38 1.29e-10 Type 2 diabetes; CESC cis rs7666738 0.830 rs11944035 chr4:98931618 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11088226 0.681 rs16989507 chr21:33939509 T/G cg09050820 chr6:167586206 TCP10L2 0.83 7.75 0.43 2.01e-13 Gastritis; CESC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg04025307 chr7:1156635 C7orf50 0.5 8.22 0.45 9.39e-15 Longevity;Endometriosis; CESC trans rs8073060 0.586 rs6505484 chr17:33993152 G/A cg19694781 chr19:47549865 TMEM160 -0.75 -7.38 -0.41 2.07e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs11583043 1.000 rs7521424 chr1:101475901 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.52 5.78 0.33 2.1e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs17253792 0.822 rs10083493 chr14:56045411 C/T cg01858014 chr14:56050164 KTN1 -0.96 -7.65 -0.43 3.84e-13 Putamen volume; CESC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.12 0.81 3.99e-62 Prudent dietary pattern; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17172773 chr1:150980817 FAM63A;PRUNE -0.48 -6.62 -0.38 1.99e-10 Ulcerative colitis; CESC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg24060327 chr5:131705240 SLC22A5 0.76 10.81 0.55 8.47e-23 Breast cancer; CESC cis rs477692 0.935 rs557158 chr10:131420534 C/T cg05714579 chr10:131428358 MGMT 0.46 6.23 0.36 1.8e-9 Response to temozolomide; CESC cis rs548181 0.736 rs1941558 chr11:125425606 C/T cg03464685 chr11:125439445 EI24 1.15 9.55 0.51 9.09e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs477692 0.669 rs12265939 chr10:131445398 A/G cg24747557 chr10:131355152 MGMT 0.38 5.28 0.31 2.72e-7 Response to temozolomide; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11303561 chr19:1206399 STK11 0.59 6.69 0.38 1.32e-10 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg27170947 chr2:26402098 FAM59B -0.58 -6.92 -0.39 3.46e-11 Gut microbiome composition (summer); CESC cis rs5995756 0.736 rs8140185 chr22:40010806 A/G cg03390717 chr22:39966585 CACNA1I 0.29 5.13 0.3 5.48e-7 Autism spectrum disorder or schizophrenia; CESC cis rs897984 0.806 rs1458202 chr16:30953202 A/G cg02466173 chr16:30829666 NA -0.48 -8.06 -0.44 2.55e-14 Dementia with Lewy bodies; CESC cis rs2236918 0.932 rs1776178 chr1:242011534 C/T cg17736920 chr1:242011382 EXO1 -0.72 -9.7 -0.51 3.05e-19 Menopause (age at onset); CESC cis rs12142240 1.000 rs12146051 chr1:46742952 G/C cg00530320 chr1:46809349 NSUN4 0.55 6.63 0.38 1.87e-10 Menopause (age at onset); CESC cis rs34172651 0.583 rs4787649 chr16:24700215 C/T cg06028605 chr16:24865363 SLC5A11 -0.45 -6.69 -0.38 1.28e-10 Intelligence (multi-trait analysis); CESC cis rs4722166 0.630 rs4722168 chr7:22779002 G/A cg13104385 chr7:22767384 IL6 0.48 6.43 0.37 5.96e-10 Lung cancer; CESC cis rs34779708 0.966 rs7070427 chr10:35485689 A/T cg03585969 chr10:35415529 CREM 0.76 9.94 0.52 5.54e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg27116842 chr5:66300503 MAST4 -0.49 -6.24 -0.36 1.75e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4654899 0.758 rs1609558 chr1:21525228 C/T cg05370193 chr1:21551575 ECE1 -0.4 -6.08 -0.35 4.11e-9 Superior frontal gyrus grey matter volume; CESC cis rs4704187 0.687 rs9293650 chr5:74497084 C/T cg03227963 chr5:74354835 NA 0.28 5.09 0.3 6.69e-7 Response to amphetamines; CESC cis rs3768617 0.510 rs2296300 chr1:183099701 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs6540556 0.723 rs12060420 chr1:209906819 T/G cg05527609 chr1:210001259 C1orf107 -0.62 -7.17 -0.4 7.59e-12 Red blood cell count; CESC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg03806693 chr22:41940476 POLR3H -1.06 -12.46 -0.61 2.35e-28 Vitiligo; CESC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.65 0.64 1.8e-32 Prudent dietary pattern; CESC cis rs6674176 0.542 rs803679 chr1:44349405 G/A cg13606994 chr1:44402422 ARTN -0.38 -5.33 -0.31 2.11e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs559928 0.597 rs11600667 chr11:63976183 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.62 5.28 0.31 2.7e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs9911578 1.000 rs4482353 chr17:56896834 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -6.87 -0.39 4.62e-11 Intelligence (multi-trait analysis); CESC cis rs4450798 0.649 rs9855179 chr3:13790981 G/A cg23332027 chr3:13681764 NA 0.38 5.13 0.3 5.63e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs2635047 0.967 rs2576030 chr18:44659166 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 7.09 0.4 1.2e-11 Educational attainment; CESC cis rs7586673 0.857 rs16845580 chr2:161920884 T/C cg21518248 chr2:162101506 NA 0.47 6.4 0.37 6.96e-10 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14460003 chr20:31173015 NA 0.55 6.04 0.35 5.12e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06767762 chr16:70323488 AARS -0.61 -7.57 -0.42 6.29e-13 Gut microbiome composition (summer); CESC cis rs9611565 0.559 rs7290991 chr22:41964361 C/G cg03806693 chr22:41940476 POLR3H -0.97 -12.07 -0.6 4.96e-27 Vitiligo; CESC cis rs11122272 0.732 rs999010 chr1:231495316 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.16 -0.45 1.38e-14 Hemoglobin concentration; CESC cis rs6463523 0.898 rs66892628 chr7:759374 T/A cg14391382 chr7:866102 UNC84A 0.48 5.97 0.34 7.53e-9 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00188822 chr20:44044780 PIGT 0.58 7.17 0.4 7.52e-12 Gut microbiome composition (summer); CESC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg01341218 chr17:43662625 NA 0.92 10.78 0.55 1.08e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7949030 0.596 rs11231137 chr11:62315699 G/A cg23462726 chr11:62437636 C11orf83;C11orf48 -0.44 -5.71 -0.33 2.98e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg10556349 chr10:835070 NA 0.58 5.59 0.32 5.56e-8 Eosinophil percentage of granulocytes; CESC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg04772025 chr11:68637568 NA -0.56 -6.78 -0.38 7.57e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.28 0.31 2.75e-7 Menopause (age at onset); CESC cis rs12348691 0.503 rs7023267 chr9:100603935 G/A cg13688889 chr9:100608707 NA -0.87 -13.26 -0.63 4.01e-31 Alopecia areata; CESC cis rs11711311 0.712 rs3773684 chr3:113334488 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.58 -7.86 -0.43 9.74e-14 IgG glycosylation; CESC cis rs5757673 1 rs5757673 chr22:39837920 T/C cg01416388 chr22:39784598 NA -0.66 -7.62 -0.42 4.45e-13 Post bronchodilator FEV1; CESC cis rs72945132 0.882 rs3781648 chr11:70190058 T/C cg14191688 chr11:70257035 CTTN 0.41 5.13 0.3 5.6e-7 Coronary artery disease; CESC cis rs7845219 0.544 rs10956930 chr8:95919786 C/G cg13393036 chr8:95962371 TP53INP1 -0.42 -7.77 -0.43 1.69e-13 Type 2 diabetes; CESC cis rs3733585 0.578 rs6837224 chr4:9955255 G/T cg02734326 chr4:10020555 SLC2A9 -0.4 -5.77 -0.33 2.19e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs35110281 0.626 rs162388 chr21:44936032 G/A cg01579765 chr21:45077557 HSF2BP -0.49 -8.76 -0.47 2.41e-16 Mean corpuscular volume; CESC cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7520050 0.966 rs4660898 chr1:46402171 A/G cg03146154 chr1:46216737 IPP -0.46 -5.92 -0.34 9.78e-9 Red blood cell count;Reticulocyte count; CESC cis rs7523050 0.730 rs12729728 chr1:109431110 C/A cg08274380 chr1:109419600 GPSM2 0.94 6.43 0.37 5.76e-10 Fat distribution (HIV); CESC cis rs977987 0.806 rs11864102 chr16:75442360 C/T cg03315344 chr16:75512273 CHST6 0.41 5.81 0.34 1.77e-8 Dupuytren's disease; CESC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg13628971 chr7:2884303 GNA12 0.64 8.13 0.45 1.63e-14 Height; CESC cis rs3733585 0.578 rs4466042 chr4:9955367 T/C cg00071950 chr4:10020882 SLC2A9 -0.69 -11.31 -0.57 1.83e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg09359103 chr1:154839909 KCNN3 -0.49 -7.75 -0.43 2.03e-13 Prostate cancer; CESC cis rs11098499 0.954 rs10518331 chr4:120323595 C/T cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs6594499 0.872 rs10060003 chr5:110449357 A/G cg04022379 chr5:110408740 TSLP 0.32 5.63 0.33 4.49e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12618769 0.597 rs72821943 chr2:99141640 T/C cg10123293 chr2:99228465 UNC50 0.41 5.44 0.32 1.24e-7 Bipolar disorder; CESC cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11080062 chr12:53615449 RARG 0.55 6.65 0.38 1.69e-10 Gut microbiome composition (summer); CESC cis rs4843747 0.697 rs72818533 chr16:88073841 G/A cg03395651 chr16:88107091 BANP 0.45 5.17 0.3 4.54e-7 Menopause (age at onset); CESC cis rs1044826 0.647 rs4683463 chr3:139196946 T/G cg00490450 chr3:139108681 COPB2 0.43 5.34 0.31 2e-7 Obesity-related traits; CESC cis rs858239 0.601 rs10255228 chr7:23158863 G/T cg23682824 chr7:23144976 KLHL7 0.55 7.76 0.43 1.85e-13 Cerebrospinal fluid biomarker levels; CESC cis rs6500395 0.926 rs9929569 chr16:48677584 C/T cg04672837 chr16:48644449 N4BP1 0.46 5.46 0.32 1.08e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1044826 0.692 rs169824 chr3:139235006 G/C cg00490450 chr3:139108681 COPB2 -0.45 -5.45 -0.32 1.15e-7 Obesity-related traits; CESC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg22823121 chr1:150693482 HORMAD1 0.45 6.35 0.36 9.19e-10 Melanoma; CESC cis rs977987 0.843 rs59465235 chr16:75483810 C/G cg03315344 chr16:75512273 CHST6 0.43 6.26 0.36 1.5e-9 Dupuytren's disease; CESC cis rs7020830 0.825 rs66684257 chr9:37199087 G/T cg14294708 chr9:37120828 ZCCHC7 1.11 20.24 0.78 1.02e-55 Schizophrenia; CESC trans rs877282 0.945 rs10904555 chr10:787740 C/A cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs2735413 0.918 rs4888728 chr16:78077199 C/G cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10949413 chr6:26158832 HIST1H2BD -0.4 -6.32 -0.36 1.11e-9 Gambling; CESC cis rs6541297 0.757 rs600845 chr1:230322708 C/T cg20703242 chr1:230279135 GALNT2 0.4 5.31 0.31 2.36e-7 Coronary artery disease; CESC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg24209194 chr3:40518798 ZNF619 0.49 6.23 0.36 1.78e-9 Renal cell carcinoma; CESC cis rs2011503 1.000 rs6511031 chr19:19471506 T/C cg11584989 chr19:19387371 SF4 -0.64 -7.5 -0.42 9.58e-13 Bipolar disorder; CESC cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg18769074 chr3:133464867 TF 0.31 6.04 0.35 5.17e-9 Iron status biomarkers (transferrin levels); CESC cis rs10911232 0.507 rs10752891 chr1:183023283 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.5 0.64 6.03e-32 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11767392 chr11:71814388 LRTOMT;C11orf59 0.55 6.77 0.38 8.34e-11 Gut microbiome composition (summer); CESC cis rs6088580 0.668 rs1205337 chr20:32926041 T/A cg08999081 chr20:33150536 PIGU -0.64 -10.99 -0.56 2.0500000000000001e-23 Glomerular filtration rate (creatinine); CESC cis rs3820068 0.581 rs16851855 chr1:15930869 G/A cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC trans rs1814175 0.781 rs28681334 chr11:50051177 C/T cg03929089 chr4:120376271 NA -0.94 -15.72 -0.69 8.37e-40 Height; CESC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg11764359 chr7:65958608 NA 0.7 9.39 0.5 2.84e-18 Aortic root size; CESC cis rs938554 0.612 rs7669607 chr4:9997801 C/T cg11266682 chr4:10021025 SLC2A9 -0.44 -6.28 -0.36 1.38e-9 Blood metabolite levels; CESC cis rs12136530 0.774 rs10442642 chr1:19773818 A/G cg01832549 chr1:19774989 CAPZB -0.47 -6.59 -0.38 2.36e-10 Lead levels in blood; CESC cis rs897984 0.542 rs35713203 chr16:31090407 G/C cg02466173 chr16:30829666 NA -0.45 -7.42 -0.41 1.59e-12 Dementia with Lewy bodies; CESC cis rs11122272 0.735 rs2474631 chr1:231541341 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.28 -0.41 3.74e-12 Hemoglobin concentration; CESC cis rs2439831 0.867 rs2447211 chr15:43936351 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.81 8.46 0.46 1.81e-15 Lung cancer in ever smokers; CESC cis rs1008375 1.000 rs62295634 chr4:17685346 C/A cg16339924 chr4:17578868 LAP3 0.51 6.49 0.37 4.31e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1371867 0.875 rs1788174 chr8:101330957 C/G cg11906718 chr8:101322791 RNF19A -0.49 -6.29 -0.36 1.28e-9 Atrioventricular conduction; CESC cis rs6964587 0.839 rs10236107 chr7:91485461 G/A cg17063962 chr7:91808500 NA -0.5 -6.56 -0.37 2.77e-10 Breast cancer; CESC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg22535103 chr8:58192502 C8orf71 -0.93 -9.27 -0.49 6.95e-18 Developmental language disorder (linguistic errors); CESC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg11764359 chr7:65958608 NA -0.78 -11.43 -0.57 7.35e-25 Aortic root size; CESC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.09 0.6 4.37e-27 Alzheimer's disease; CESC cis rs7592578 0.664 rs10931461 chr2:191405280 T/A cg27211696 chr2:191398769 TMEM194B 0.59 5.32 0.31 2.22e-7 Diastolic blood pressure; CESC cis rs4727027 0.870 rs1534196 chr7:148790591 G/A cg23158103 chr7:148848205 ZNF398 -0.42 -6.93 -0.39 3.25e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7508 0.694 rs2410447 chr8:17923147 T/C cg18067069 chr8:17937731 ASAH1 -0.41 -5.43 -0.32 1.28e-7 Atrial fibrillation; CESC cis rs9733 0.635 rs486836 chr1:150875967 A/T cg18016565 chr1:150552671 MCL1 -0.37 -5.94 -0.34 8.72e-9 Tonsillectomy; CESC cis rs8141529 0.732 rs11556025 chr22:29168755 T/C cg02153584 chr22:29168773 CCDC117 0.69 9.74 0.51 2.27e-19 Lymphocyte counts; CESC cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg15556689 chr8:8085844 FLJ10661 0.53 6.55 0.37 2.92e-10 Mood instability; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00400810 chr15:42066822 MAPKBP1 -0.5 -6.19 -0.36 2.29e-9 Ulcerative colitis; CESC cis rs1707322 0.506 rs2991983 chr1:46079391 T/C cg06784218 chr1:46089804 CCDC17 -0.41 -7.2 -0.4 6.06e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg22455660 chr9:128509791 PBX3 -0.47 -6.08 -0.35 4.24e-9 Height; CESC cis rs2952156 0.920 rs11078919 chr17:37835755 T/C cg20243544 chr17:37824526 PNMT 0.63 8.42 0.46 2.43e-15 Asthma; CESC cis rs4450798 0.649 rs9845991 chr3:13778031 C/A cg05589046 chr3:13742034 LOC285375 0.34 5.09 0.3 6.68e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12940430 chr6:43138965 SRF -0.5 -6.42 -0.37 6.09e-10 Gut microbiota (bacterial taxa); CESC cis rs1707322 0.685 rs6690926 chr1:46134978 T/C cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00408597 chr11:9685941 SWAP70 0.59 7.04 0.4 1.63e-11 Gut microbiome composition (summer); CESC cis rs12900413 0.564 rs8035800 chr15:90314790 T/C cg24249390 chr15:90295951 MESP1 -0.41 -5.73 -0.33 2.78e-8 Coronary artery aneurysm in Kawasaki disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10450178 chr12:89920041 WDR51B -0.63 -7.28 -0.41 3.74e-12 Gut microbiome composition (summer); CESC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg07211511 chr3:129823064 LOC729375 -0.58 -7.37 -0.41 2.19e-12 Blood pressure (smoking interaction); CESC cis rs2249694 1.000 rs4363513 chr10:135355534 A/G cg20169779 chr10:135381914 SYCE1 0.42 5.74 0.33 2.58e-8 Obesity-related traits; CESC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg04414720 chr1:150670196 GOLPH3L 0.52 6.8 0.39 6.72e-11 Melanoma; CESC cis rs12681288 0.676 rs2701914 chr8:999935 C/T cg15309053 chr8:964076 NA 0.39 6.61 0.38 2.11e-10 Schizophrenia; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg18346038 chr20:33264828 PIGU -0.51 -6.22 -0.36 1.93e-9 Psoriatic arthritis; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06347499 chr1:9599419 SLC25A33 0.43 6.0 0.35 6.6e-9 Intelligence (multi-trait analysis); CESC cis rs10129255 0.536 rs6576223 chr14:107184687 C/T cg23076370 chr14:107095027 NA -0.66 -9.85 -0.52 1.08e-19 Kawasaki disease; CESC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg27094323 chr7:1216898 NA -0.39 -5.45 -0.32 1.17e-7 Longevity;Endometriosis; CESC cis rs4727027 0.899 rs6944096 chr7:148870026 A/G cg23158103 chr7:148848205 ZNF398 -0.37 -5.85 -0.34 1.44e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9324022 0.929 rs59488041 chr14:101180041 T/A cg18089426 chr14:101175970 NA 0.55 7.07 0.4 1.37e-11 Plateletcrit; CESC cis rs8111998 0.826 rs4932778 chr19:22766971 G/A cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs6582630 0.615 rs11182380 chr12:38511735 G/T cg26384229 chr12:38710491 ALG10B -0.41 -5.41 -0.32 1.39e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs1881797 0.932 rs10925071 chr1:247686521 C/T cg21399703 chr1:247681439 NA -0.52 -7.46 -0.42 1.22e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs1808579 0.935 rs6507716 chr18:21115060 A/G cg14672496 chr18:21087552 C18orf8 0.43 6.43 0.37 6.04e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs10504073 0.631 rs341813 chr8:50039916 T/C cg00325661 chr8:49890786 NA 0.5 7.28 0.41 3.89e-12 Blood metabolite ratios; CESC cis rs611744 0.631 rs681963 chr8:109255032 C/A cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.65e-8 Dupuytren's disease; CESC cis rs6963495 0.818 rs73192144 chr7:105203535 C/T cg19920283 chr7:105172520 RINT1 0.7 6.54 0.37 3.09e-10 Bipolar disorder (body mass index interaction); CESC cis rs7246657 0.891 rs7257495 chr19:37823876 C/G cg23950597 chr19:37808831 NA -0.55 -6.04 -0.35 5.24e-9 Coronary artery calcification; CESC cis rs694739 0.628 rs508168 chr11:64135435 G/A cg23796481 chr11:64053134 BAD;GPR137 0.58 7.09 0.4 1.23e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs7267979 1.000 rs4815409 chr20:25346697 C/A cg08601574 chr20:25228251 PYGB -0.38 -5.46 -0.32 1.12e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs4253772 0.591 rs6007795 chr22:46686792 C/G cg24881330 chr22:46731750 TRMU 0.94 10.35 0.54 2.62e-21 LDL cholesterol;Cholesterol, total; CESC cis rs4629710 0.592 rs9492868 chr6:131542238 A/C cg12606694 chr6:131520996 AKAP7 0.46 5.67 0.33 3.79e-8 Multiple myeloma (IgH translocation); CESC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg21770322 chr7:97807741 LMTK2 0.55 8.41 0.46 2.49e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs2228479 1.000 rs4257207 chr16:89947861 T/A cg04013166 chr16:89971882 TCF25 0.76 6.47 0.37 4.59e-10 Skin colour saturation; CESC cis rs4955124 0.558 rs60434847 chr3:32017702 T/G cg05935571 chr3:32023257 ZNF860;OSBPL10 1.0 8.4 0.46 2.67e-15 Schizophrenia; CESC cis rs1048238 0.506 rs12039892 chr1:16167974 A/G cg21385522 chr1:16154831 NA 0.42 5.31 0.31 2.35e-7 Systolic blood pressure; CESC cis rs7586673 0.725 rs6757645 chr2:161891382 A/G cg22496339 chr2:162101262 NA 0.41 5.17 0.3 4.63e-7 Intelligence (multi-trait analysis); CESC cis rs2050392 0.624 rs2489842 chr10:30721991 T/C cg18806716 chr10:30721971 MAP3K8 -0.64 -9.55 -0.51 9.14e-19 Inflammatory bowel disease; CESC cis rs5769765 0.862 rs138897 chr22:50231067 T/C cg02269571 chr22:50332266 NA -0.47 -6.02 -0.35 5.66e-9 Schizophrenia; CESC cis rs17253792 0.822 rs79024594 chr14:56092997 T/G cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.545 rs1663283 chr12:38132039 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.92 -0.34 9.92e-9 Bladder cancer; CESC cis rs66573146 0.901 rs55882710 chr4:7030704 G/A cg00086871 chr4:6988644 TBC1D14 0.88 5.04 0.3 8.81e-7 Granulocyte percentage of myeloid white cells; CESC cis rs7116495 1.000 rs10751190 chr11:71680757 C/T cg26138937 chr11:71823887 C11orf51 -0.79 -6.51 -0.37 3.77e-10 Severe influenza A (H1N1) infection; CESC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.93 0.34 9.3e-9 Tonsillectomy; CESC cis rs74181299 0.890 rs2540950 chr2:65279223 C/T cg05010058 chr2:65284262 CEP68 0.33 5.66 0.33 3.89e-8 Pulse pressure; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02021460 chr16:19729639 C16orf88;IQCK 0.46 6.09 0.35 3.85e-9 Systemic lupus erythematosus; CESC cis rs6831352 0.918 rs2851246 chr4:100046104 A/G cg13256891 chr4:100009986 ADH5 0.78 8.94 0.48 7.06e-17 Alcohol dependence; CESC cis rs9583531 0.527 rs6492302 chr13:111352354 C/T cg24331049 chr13:111365604 ING1 -0.7 -10.5 -0.54 8.67e-22 Coronary artery disease; CESC trans rs9858542 0.953 rs10640 chr3:49454277 G/A cg21659725 chr3:3221576 CRBN -0.55 -6.55 -0.37 2.92e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg04553112 chr3:125709451 NA -0.54 -5.97 -0.34 7.6e-9 Blood pressure (smoking interaction); CESC cis rs2243480 1.000 rs316332 chr7:65604299 A/G cg18252515 chr7:66147081 NA -1.33 -13.37 -0.63 1.61e-31 Diabetic kidney disease; CESC cis rs11690935 0.959 rs77280952 chr2:172620151 G/C cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.87 -0.67 9.1e-37 Schizophrenia; CESC cis rs1008375 1.000 rs3815414 chr4:17606659 A/G cg16339924 chr4:17578868 LAP3 -0.6 -7.6 -0.42 4.97e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2279817 0.743 rs3766309 chr1:17977378 C/T cg21791023 chr1:18019539 ARHGEF10L -0.47 -6.62 -0.38 2.03e-10 Neuroticism; CESC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.91 9.82 0.52 1.26e-19 Platelet count; CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg18337363 chr3:52569053 NT5DC2 0.31 6.0 0.35 6.63e-9 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22377027 chr1:12040208 MFN2 0.57 6.04 0.35 5.32e-9 Gut microbiome composition (summer); CESC cis rs9902453 0.817 rs62068625 chr17:28176581 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 8.47 0.46 1.75e-15 Coffee consumption (cups per day); CESC cis rs9581857 0.579 rs76578450 chr13:27982656 C/A cg01674679 chr13:27998804 GTF3A -0.65 -5.19 -0.3 4.26e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg10691866 chr7:65817282 TPST1 0.31 5.37 0.31 1.75e-7 Aortic root size; CESC cis rs7829975 0.511 rs2921028 chr8:8340477 T/C cg06636001 chr8:8085503 FLJ10661 0.41 5.06 0.3 7.94e-7 Mood instability; CESC cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg22875332 chr1:76189707 ACADM 0.7 9.66 0.51 4.13e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1023500 0.551 rs133379 chr22:42468535 A/G cg04733989 chr22:42467013 NAGA 0.8 11.49 0.58 4.5e-25 Schizophrenia; CESC cis rs6991838 0.584 rs66486920 chr8:66486693 C/T cg13398993 chr8:66546079 ARMC1 -0.46 -5.54 -0.32 7.22e-8 Intelligence (multi-trait analysis); CESC cis rs2439831 1.000 rs2245790 chr15:43744457 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.8 11.71 0.58 8.62e-26 Lung cancer in ever smokers; CESC cis rs11690935 0.851 rs10201430 chr2:172813241 T/C cg13550731 chr2:172543902 DYNC1I2 -0.72 -10.6 -0.55 4.18e-22 Schizophrenia; CESC trans rs4950322 0.547 rs61838945 chr1:146583059 G/T cg04954894 chr8:38089920 DDHD2 -0.58 -6.36 -0.36 8.8e-10 Protein quantitative trait loci; CESC cis rs2414059 0.518 rs3098171 chr15:50771511 C/G cg08437265 chr15:50716283 USP8 -0.49 -6.46 -0.37 4.98e-10 QT interval; CESC cis rs5769765 0.908 rs9627800 chr22:50319351 T/C cg02269571 chr22:50332266 NA -0.55 -6.42 -0.37 6.1e-10 Schizophrenia; CESC cis rs9815354 0.812 rs73830516 chr3:41876056 A/G cg03022575 chr3:42003672 ULK4 0.71 6.21 0.36 1.99e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.19 0.4 6.81e-12 Height; CESC cis rs6570726 0.846 rs6570698 chr6:145918635 C/G cg23711669 chr6:146136114 FBXO30 0.83 12.25 0.6 1.19e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs9858542 0.953 rs9858280 chr3:49597737 T/C cg03060546 chr3:49711283 APEH -0.51 -5.99 -0.35 6.8e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2832191 0.716 rs7509628 chr21:30454252 C/T cg08807101 chr21:30365312 RNF160 0.94 14.55 0.67 1.17e-35 Dental caries; CESC cis rs34381861 0.520 rs74382390 chr16:71458526 C/G cg08717414 chr16:71523259 ZNF19 -0.81 -8.01 -0.44 3.73e-14 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03104765 chr7:129414868 MIR183;MIR96 -0.57 -6.31 -0.36 1.2e-9 Gut microbiome composition (summer); CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg26719024 chr10:105156444 PDCD11;USMG5 0.53 6.02 0.35 5.8e-9 Endometrial cancer; CESC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg13126279 chr21:47581558 C21orf56 0.5 6.89 0.39 4.07e-11 Testicular germ cell tumor; CESC cis rs2108225 0.872 rs4618632 chr7:107440952 T/G cg18560240 chr7:107437656 SLC26A3 -0.43 -5.92 -0.34 9.83e-9 Ulcerative colitis; CESC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg19592336 chr6:28129416 ZNF389 0.44 6.46 0.37 4.98e-10 Cardiac Troponin-T levels; CESC cis rs6142102 0.625 rs6142062 chr20:32548512 C/G cg08999081 chr20:33150536 PIGU 0.34 5.11 0.3 6.04e-7 Skin pigmentation; CESC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -7.71 -0.43 2.5e-13 Personality dimensions; CESC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.49 0.42 1.01e-12 Prudent dietary pattern; CESC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg19346786 chr7:2764209 NA 0.5 7.38 0.41 2.11e-12 Height; CESC cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg01475377 chr6:109611718 NA -0.48 -7.82 -0.43 1.26e-13 Reticulocyte fraction of red cells; CESC cis rs864537 0.622 rs1214598 chr1:167426424 C/T cg22356347 chr1:167427500 CD247 -0.4 -8.42 -0.46 2.37e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs16895831 0.519 rs4714614 chr6:42592183 A/G cg10605015 chr6:42532144 UBR2 -0.47 -5.18 -0.3 4.34e-7 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs7191439 0.858 rs8044367 chr16:88783374 A/G cg27087555 chr16:88793112 FAM38A -1.22 -9.32 -0.5 4.71e-18 Plateletcrit; CESC cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 5.96e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6942756 0.806 rs6467237 chr7:128964831 A/G cg02491457 chr7:128862824 NA -0.61 -8.58 -0.47 8.27e-16 White matter hyperintensity burden; CESC cis rs9611565 0.681 rs132918 chr22:41808350 C/T cg06634786 chr22:41940651 POLR3H 0.63 6.75 0.38 9.04e-11 Vitiligo; CESC cis rs1215050 0.791 rs165244 chr4:98687889 C/T cg05340658 chr4:99064831 C4orf37 0.47 5.97 0.34 7.77e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4889855 0.530 rs12946972 chr17:78618922 A/G cg09596252 chr17:78655493 RPTOR 0.41 5.12 0.3 5.92e-7 Fractional excretion of uric acid; CESC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg21782813 chr7:2030301 MAD1L1 -0.4 -5.86 -0.34 1.4e-8 Bipolar disorder and schizophrenia; CESC cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg25019033 chr10:957182 NA -0.63 -7.83 -0.43 1.14e-13 Eosinophil percentage of granulocytes; CESC cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg23131131 chr22:24373011 LOC391322 0.61 7.49 0.42 1.01e-12 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs56046484 0.871 rs62021230 chr15:85583952 C/T cg08123816 chr15:85640762 PDE8A -0.48 -5.85 -0.34 1.46e-8 Testicular germ cell tumor; CESC cis rs1801251 0.896 rs79793315 chr2:233690864 C/T cg25237894 chr2:233734115 C2orf82 -0.37 -6.71 -0.38 1.19e-10 Coronary artery disease; CESC cis rs7000551 0.532 rs55726237 chr8:22252985 C/T cg12081754 chr8:22256438 SLC39A14 0.92 12.64 0.61 5.75e-29 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09922935 chr17:34842385 ZNHIT3 0.52 6.48 0.37 4.55e-10 Gut microbiota (bacterial taxa); CESC cis rs11785400 1.000 rs13266249 chr8:143732433 A/C cg10596483 chr8:143751796 JRK 0.43 5.58 0.32 5.95e-8 Schizophrenia; CESC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg05564831 chr3:52568323 NT5DC2 0.48 7.55 0.42 7.01e-13 Electroencephalogram traits; CESC cis rs826838 0.967 rs1352122 chr12:39130885 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.27 -0.36 1.48e-9 Heart rate; CESC cis rs17376456 0.569 rs68122392 chr5:93077807 A/T cg25358565 chr5:93447407 FAM172A 0.68 7.24 0.41 5.01e-12 Diabetic retinopathy; CESC cis rs4666360 1.000 rs4666294 chr2:20336753 C/G cg23291376 chr2:20336282 NA 0.37 6.18 0.35 2.46e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel); CESC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.77 10.99 0.56 2.19e-23 Alzheimer's disease; CESC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg11494091 chr17:61959527 GH2 0.73 12.43 0.61 2.85e-28 Prudent dietary pattern; CESC cis rs7772486 0.686 rs6570701 chr6:145954090 A/G cg05347473 chr6:146136440 FBXO30 0.56 7.24 0.41 4.97e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs713587 0.520 rs839652 chr2:25334340 C/T cg01884057 chr2:25150051 NA -0.3 -5.21 -0.3 3.89e-7 Body mass index in non-asthmatics; CESC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.12 0.3 5.88e-7 Menopause (age at onset); CESC cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg06453172 chr10:134556979 INPP5A -0.4 -5.36 -0.31 1.79e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs34779708 0.898 rs4934695 chr10:35280605 C/T cg03585969 chr10:35415529 CREM 0.77 10.3 0.53 3.84e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs9640161 0.789 rs34728606 chr7:150054694 G/A cg21361702 chr7:150065534 REPIN1 0.6 6.45 0.37 5.33e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs7116495 1.000 rs10128658 chr11:71733519 C/T cg10381502 chr11:71823885 C11orf51 -0.64 -5.21 -0.3 3.81e-7 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25738037 chr1:168025549 DCAF6 -0.68 -7.57 -0.42 6.39e-13 Gut microbiome composition (summer); CESC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg22823121 chr1:150693482 HORMAD1 0.4 5.6 0.33 5.34e-8 Melanoma; CESC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg23161317 chr6:28129485 ZNF389 0.52 6.63 0.38 1.86e-10 Depression; CESC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg18190219 chr22:46762943 CELSR1 -0.55 -5.47 -0.32 1.04e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg05564831 chr3:52568323 NT5DC2 0.44 6.68 0.38 1.37e-10 Bipolar disorder; CESC cis rs8058578 0.832 rs35969813 chr16:30714417 T/C cg02466173 chr16:30829666 NA -0.48 -7.27 -0.41 3.94e-12 Multiple myeloma; CESC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC cis rs7017697 1.000 rs10092772 chr8:19686385 A/T cg01411142 chr8:19674711 INTS10 -0.48 -5.72 -0.33 2.88e-8 Breast cancer; CESC cis rs6912958 0.535 rs1753154 chr6:88032843 G/C cg12350822 chr6:88032061 C6orf162;GJB7 0.51 8.85 0.48 1.31e-16 Monocyte percentage of white cells; CESC cis rs17666538 0.585 rs336444 chr8:633123 C/G cg23958373 chr8:599963 NA -0.67 -5.93 -0.34 9.44e-9 IgG glycosylation; CESC cis rs9916302 0.706 rs8078599 chr17:37518660 C/T cg07936489 chr17:37558343 FBXL20 0.9 9.49 0.5 1.38e-18 Glomerular filtration rate (creatinine); CESC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg12463550 chr7:65579703 CRCP -0.49 -6.4 -0.37 6.95e-10 Aortic root size; CESC cis rs7937682 0.961 rs7119563 chr11:111543916 T/A cg22437258 chr11:111473054 SIK2 -0.65 -7.35 -0.41 2.39e-12 Primary sclerosing cholangitis; CESC cis rs4843747 0.671 rs4072871 chr16:88106614 C/T cg06374794 chr16:88002281 BANP 0.4 5.18 0.3 4.32e-7 Menopause (age at onset); CESC cis rs919433 0.783 rs788011 chr2:198230771 A/G cg20885578 chr2:198174922 NA 0.41 5.36 0.31 1.79e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs314370 0.621 rs314312 chr7:100422642 G/C cg10426581 chr7:100472382 SRRT 0.49 5.47 0.32 1.06e-7 Resting heart rate; CESC cis rs7666738 0.830 rs7691433 chr4:98968118 A/T cg05340658 chr4:99064831 C4orf37 0.78 11.27 0.57 2.55e-24 Colonoscopy-negative controls vs population controls; CESC cis rs1904096 0.506 rs10024642 chr4:95179295 A/G cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.28 -0.5 6.25e-18 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16303825 chr3:10362878 SEC13 0.56 6.33 0.36 1.03e-9 Gut microbiome composition (summer); CESC trans rs17764205 0.929 rs8101372 chr19:3253830 T/C cg19548313 chr19:1065712 HMHA1 -0.49 -6.01 -0.35 6.14e-9 Bipolar disorder and schizophrenia; CESC cis rs926938 0.527 rs360670 chr1:115482386 G/A cg12756093 chr1:115239321 AMPD1 0.45 6.18 0.35 2.44e-9 Autism; CESC trans rs11191205 0.644 rs10883667 chr10:103384849 A/T cg12418535 chr2:119607192 EN1 -0.4 -6.0 -0.35 6.56e-9 Intelligence (multi-trait analysis); CESC cis rs4660306 0.884 rs7543076 chr1:45964238 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.86e-13 Homocysteine levels; CESC cis rs72387598 1 rs72387598 chr1:45922977 CAT/C cg05343316 chr1:45956843 TESK2 0.91 12.32 0.6 7.03e-28 Platelet distribution width; CESC cis rs12824058 0.678 rs11614163 chr12:130814621 C/G cg26677194 chr12:130822605 PIWIL1 0.53 6.64 0.38 1.82e-10 Menopause (age at onset); CESC cis rs365132 0.875 rs2962844 chr5:176333748 G/T cg16309518 chr5:176445507 NA -0.36 -5.23 -0.31 3.41e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg12963246 chr6:28129442 ZNF389 0.46 5.59 0.32 5.57e-8 Depression; CESC cis rs9815354 0.812 rs17216919 chr3:41888938 G/C cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.84e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6963495 0.818 rs6957192 chr7:105150255 A/C cg02135003 chr7:105160482 PUS7 0.46 5.69 0.33 3.36e-8 Bipolar disorder (body mass index interaction); CESC cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg01579765 chr21:45077557 HSF2BP -0.57 -9.89 -0.52 7.73e-20 Mean corpuscular volume; CESC trans rs885518 0.852 rs10965131 chr9:21782230 T/A cg07328519 chr19:4064300 ZBTB7A 0.5 6.08 0.35 4.19e-9 Lung adenocarcinoma; CESC cis rs2406342 0.528 rs75536638 chr18:74499060 G/T cg03731646 chr18:74499372 NA 0.44 5.77 0.33 2.2e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); CESC cis rs1003719 0.667 rs13050226 chr21:38457708 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.52 6.54 0.37 3.08e-10 Eye color traits; CESC trans rs17685 0.712 rs56965035 chr7:75795670 G/A cg19862616 chr7:65841803 NCRNA00174 0.84 12.03 0.59 6.77e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2204008 0.774 rs11180977 chr12:38263094 G/T cg26384229 chr12:38710491 ALG10B 0.72 10.17 0.53 1.01e-20 Bladder cancer; CESC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg15117754 chr3:10150083 C3orf24 0.38 5.04 0.3 8.66e-7 Alzheimer's disease; CESC cis rs910316 0.692 rs7156586 chr14:75506230 A/T cg11812906 chr14:75593930 NEK9 0.64 8.72 0.47 3.2e-16 Height; CESC cis rs637571 0.522 rs1786175 chr11:65754808 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.74 10.66 0.55 2.65e-22 Eosinophil percentage of white cells; CESC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.46 0.42 1.23e-12 Tonsillectomy; CESC cis rs13095912 1.000 rs17523471 chr3:185304018 T/C cg11274856 chr3:185301563 NA 0.37 6.09 0.35 3.89e-9 Systolic blood pressure; CESC cis rs7520050 0.966 rs7556436 chr1:46363880 C/T cg03146154 chr1:46216737 IPP 0.47 6.11 0.35 3.61e-9 Red blood cell count;Reticulocyte count; CESC cis rs5769765 1.000 rs738711 chr22:50282603 A/G cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs8077889 1.000 rs2079005 chr17:41865627 T/G cg26893861 chr17:41843967 DUSP3 0.85 9.86 0.52 1e-19 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04709120 chr10:74451858 CCDC109A 0.57 6.9 0.39 3.79e-11 Gut microbiome composition (summer); CESC cis rs7264396 0.623 rs761827 chr20:34207897 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.48 0.37 4.47e-10 Total cholesterol levels; CESC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg19468946 chr17:37922297 IKZF3 0.39 5.07 0.3 7.62e-7 Glomerular filtration rate (creatinine); CESC cis rs10751667 0.600 rs10794342 chr11:924904 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.26 -0.31 2.98e-7 Alzheimer's disease (late onset); CESC cis rs72781680 0.898 rs55761273 chr2:23957849 A/G cg20701182 chr2:24300061 SF3B14 0.62 5.49 0.32 9.46e-8 Lymphocyte counts; CESC cis rs7084402 1.000 rs7073504 chr10:60271987 C/T cg07615347 chr10:60278583 BICC1 -0.56 -8.85 -0.48 1.27e-16 Refractive error; CESC cis rs60871478 0.898 rs35928069 chr7:823067 G/C cg05535760 chr7:792225 HEATR2 0.88 10.28 0.53 4.39e-21 Cerebrospinal P-tau181p levels; CESC cis rs8133932 0.654 rs7410101 chr21:47328383 G/A cg14185626 chr21:47401492 COL6A1 0.46 5.1 0.3 6.47e-7 Schizophrenia; CESC cis rs10504229 0.953 rs59034808 chr8:58185337 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -8.73 -0.47 3e-16 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25661132 chr6:157802429 ZDHHC14 0.62 6.87 0.39 4.45e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg17366294 chr4:99064904 C4orf37 0.57 7.96 0.44 4.98e-14 Colonoscopy-negative controls vs population controls; CESC cis rs926938 0.563 rs360586 chr1:115467489 A/G cg12756093 chr1:115239321 AMPD1 0.45 6.15 0.35 2.84e-9 Autism; CESC cis rs113835537 0.529 rs57724777 chr11:66236431 G/A cg24851651 chr11:66362959 CCS 0.53 6.17 0.35 2.49e-9 Airway imaging phenotypes; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg02477354 chr7:96339276 SHFM1 -0.52 -6.59 -0.38 2.4e-10 Recombination measurement; CESC trans rs116095464 0.558 rs62346526 chr5:220614 T/C cg00938859 chr5:1591904 SDHAP3 0.6 6.66 0.38 1.55e-10 Breast cancer; CESC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg13607699 chr17:42295918 UBTF -0.58 -7.53 -0.42 7.91e-13 Total body bone mineral density; CESC cis rs7833790 0.676 rs7834555 chr8:82697625 A/G cg27398817 chr8:82754497 SNX16 -0.42 -5.32 -0.31 2.24e-7 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22438603 chr5:127418940 SLC12A2;FLJ33630 0.67 8.22 0.45 9.16e-15 Gut microbiome composition (summer); CESC cis rs1395 0.778 rs11693660 chr2:27468856 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.45 5.86 0.34 1.35e-8 Blood metabolite levels; CESC cis rs8060686 0.920 rs73593810 chr16:67866783 C/T cg26727032 chr16:67993705 SLC12A4 -0.58 -6.26 -0.36 1.55e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg16680214 chr1:154839983 KCNN3 -0.45 -6.95 -0.39 2.84e-11 Prostate cancer; CESC cis rs17826219 0.561 rs562840 chr17:28949390 G/T cg19761014 chr17:28927070 LRRC37B2 0.73 7.36 0.41 2.26e-12 Body mass index; CESC cis rs10206020 0.885 rs6720923 chr2:1574197 T/C cg12573674 chr2:1569213 NA -0.46 -5.2 -0.3 3.96e-7 IgG glycosylation; CESC cis rs62229266 0.804 rs56279140 chr21:37424361 C/T cg08632701 chr21:37451849 NA -0.37 -5.2 -0.3 3.98e-7 Mitral valve prolapse; CESC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.58 0.32 5.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06557630 chr16:49889701 NA 0.49 6.08 0.35 4.14e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10664184 chr19:17420304 DDA1 -0.56 -6.39 -0.37 7.56e-10 Gut microbiome composition (summer); CESC cis rs3020736 0.500 rs6002618 chr22:42507859 G/C cg15557168 chr22:42548783 NA 0.45 6.51 0.37 3.78e-10 Autism spectrum disorder or schizophrenia; CESC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg06221963 chr1:154839813 KCNN3 -0.66 -11.39 -0.57 1.03e-24 Prostate cancer; CESC cis rs2180341 0.842 rs7739679 chr6:127545428 G/A cg24812749 chr6:127587940 RNF146 0.93 11.17 0.57 5.54e-24 Breast cancer; CESC cis rs3740713 1.000 rs2643872 chr11:18450444 A/T cg23797887 chr11:18477753 LDHAL6A -0.52 -5.19 -0.3 4.27e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2404602 0.647 rs11629727 chr15:77009038 G/C cg23625390 chr15:77176239 SCAPER -0.4 -5.2 -0.3 4e-7 Blood metabolite levels; CESC cis rs6546550 0.901 rs6736408 chr2:70137774 C/T cg02498382 chr2:70120550 SNRNP27 -0.41 -7.26 -0.41 4.34e-12 Prevalent atrial fibrillation; CESC cis rs7959452 0.503 rs7300266 chr12:69654187 A/G cg14784868 chr12:69753453 YEATS4 0.7 10.09 0.53 1.74e-20 Blood protein levels; CESC cis rs7635838 0.596 rs443503 chr3:11261912 A/T cg00170343 chr3:11313890 ATG7 -0.45 -5.6 -0.33 5.35e-8 HDL cholesterol; CESC cis rs4319547 0.688 rs10847415 chr12:123144293 T/C cg05707623 chr12:122985044 ZCCHC8 -0.46 -5.3 -0.31 2.41e-7 Body mass index; CESC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg26441486 chr22:50317300 CRELD2 0.41 5.22 0.31 3.7e-7 Schizophrenia; CESC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg18252515 chr7:66147081 NA 0.48 6.47 0.37 4.62e-10 Aortic root size; CESC cis rs2637266 1.000 rs7897061 chr10:78366776 C/T cg18941641 chr10:78392320 NA 0.42 7.81 0.43 1.33e-13 Pulmonary function; CESC cis rs9811920 0.535 rs1610509 chr3:99474327 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.33 5.51 0.32 8.64e-8 Axial length; CESC cis rs864537 0.676 rs2056625 chr1:167420299 G/A cg09179987 chr1:167433047 CD247 0.51 7.7 0.43 2.67e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs9527 0.545 rs7095304 chr10:104954795 G/A cg04362960 chr10:104952993 NT5C2 0.45 5.71 0.33 2.98e-8 Arsenic metabolism; CESC cis rs3820068 0.603 rs927207 chr1:15990552 A/G cg13390004 chr1:15929781 NA 0.34 5.47 0.32 1.06e-7 Systolic blood pressure; CESC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg17376030 chr22:41985996 PMM1 0.79 8.45 0.46 1.91e-15 Vitiligo; CESC cis rs634534 0.591 rs688862 chr11:65733393 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.39 5.56 0.32 6.45e-8 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg22029157 chr1:209979665 IRF6 0.7 7.88 0.44 8.64e-14 Cleft lip with or without cleft palate; CESC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs709400 1.000 rs709400 chr14:104149475 A/G cg12935359 chr14:103987150 CKB -0.45 -6.04 -0.35 5.3e-9 Body mass index; CESC trans rs4245128 0.896 rs2197687 chr11:112796111 G/A cg10894232 chr8:11772343 NA 0.37 6.06 0.35 4.59e-9 Life satisfaction; CESC cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg20503657 chr10:835505 NA 0.78 7.75 0.43 2.03e-13 Eosinophil percentage of granulocytes; CESC cis rs10504073 0.647 rs62507252 chr8:50028795 C/G cg00325661 chr8:49890786 NA 0.58 8.33 0.46 4.34e-15 Blood metabolite ratios; CESC cis rs80130819 0.688 rs4760698 chr12:48592872 C/T cg07561017 chr12:48398056 COL2A1 0.38 5.11 0.3 6.08e-7 Prostate cancer; CESC cis rs4268898 0.662 rs56006260 chr2:24409903 A/G cg20701182 chr2:24300061 SF3B14 0.69 6.93 0.39 3.27e-11 Asthma; CESC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg09165964 chr15:75287851 SCAMP5 0.57 7.7 0.43 2.77e-13 Caffeine consumption; CESC cis rs737337 0.623 rs12974173 chr19:11333359 A/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.52 5.41 0.32 1.37e-7 HDL cholesterol;HDL cholesterol levels; CESC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg03452623 chr4:187889614 NA 0.86 13.69 0.64 1.28e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg03351412 chr1:154909251 PMVK 0.69 9.38 0.5 3.14e-18 Prostate cancer; CESC cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 10.64 0.55 2.99e-22 Breast cancer; CESC cis rs2294693 0.947 rs9296351 chr6:40988102 T/C cg14769373 chr6:40998127 UNC5CL -0.41 -5.8 -0.34 1.92e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs35123781 0.654 rs356484 chr5:139084438 T/A cg10513866 chr5:139070639 NA 0.43 5.68 0.33 3.58e-8 Schizophrenia; CESC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.2 0.4 6.26e-12 Bipolar disorder; CESC trans rs116095464 0.558 rs62346506 chr5:201594 T/C cg00938859 chr5:1591904 SDHAP3 0.62 6.01 0.35 6.17e-9 Breast cancer; CESC trans rs916888 0.773 rs199439 chr17:44793503 A/G cg04282206 chr17:62833786 PLEKHM1P 0.56 6.52 0.37 3.49e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22254072 chr15:89902185 NA 0.55 6.21 0.36 2.09e-9 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg00166722 chr3:10149974 C3orf24 -0.48 -6.41 -0.37 6.52e-10 Alzheimer's disease; CESC cis rs2243480 1.000 rs34974928 chr7:65364006 T/C cg12463550 chr7:65579703 CRCP 0.69 5.62 0.33 4.79e-8 Diabetic kidney disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09428031 chr4:48782361 FRYL 0.47 6.25 0.36 1.67e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs9896933 0.832 rs75552659 chr17:80804630 G/A cg20578329 chr17:80767326 TBCD -0.76 -8.07 -0.44 2.48e-14 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs2228479 0.702 rs11646374 chr16:89857935 G/A cg06558623 chr16:89946397 TCF25 1.18 9.48 0.5 1.49e-18 Skin colour saturation; CESC cis rs10883723 0.810 rs7079810 chr10:104243883 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.92 -0.34 9.93e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs2576037 0.583 rs680018 chr18:44409167 T/A cg19077165 chr18:44547161 KATNAL2 -0.6 -9.05 -0.49 3.24e-17 Personality dimensions; CESC cis rs4727027 0.736 rs12704084 chr7:148915050 C/G cg23583168 chr7:148888333 NA -0.93 -15.89 -0.7 2.13e-40 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg00149659 chr3:10157352 C3orf10 0.72 9.04 0.49 3.45e-17 Alzheimer's disease; CESC cis rs7605827 0.930 rs9287663 chr2:15596076 T/G cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC cis rs6693567 0.565 rs1260398 chr1:150279876 T/C cg09579323 chr1:150459698 TARS2 -0.47 -5.99 -0.35 6.72e-9 Migraine; CESC cis rs2651899 0.867 rs2742675 chr1:3079905 A/G cg22674798 chr1:3096360 PRDM16 0.38 7.51 0.42 9.09e-13 Migraine; CESC cis rs7762018 1.000 rs6459657 chr6:170136454 A/G cg05834625 chr6:170176447 C6orf70 0.62 7.14 0.4 9.12e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7100689 0.646 rs1340382 chr10:82096997 G/C cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 5.06e-14 Post bronchodilator FEV1; CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg16145915 chr7:1198662 ZFAND2A -0.49 -5.62 -0.33 4.81e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9488822 0.676 rs11153593 chr6:116335131 C/A cg05304507 chr6:116381966 FRK 0.25 6.58 0.37 2.52e-10 Cholesterol, total;LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07512676 chr17:48785330 ANKRD40 -0.54 -6.48 -0.37 4.56e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17213946 chr1:43997516 PTPRF -0.45 -6.23 -0.36 1.78e-9 Fibrinogen levels; CESC cis rs881375 0.900 rs2241003 chr9:123666777 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.62 0.38 2.04e-10 Rheumatoid arthritis; CESC cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg03467027 chr4:99064603 C4orf37 -0.44 -5.6 -0.33 5.25e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11252926 0.502 rs7072510 chr10:455596 C/T cg16386425 chr10:429943 DIP2C -0.57 -7.4 -0.41 1.82e-12 Psychosis in Alzheimer's disease; CESC cis rs9522267 0.559 rs9522300 chr13:112236668 C/G cg10483660 chr13:112241077 NA -0.33 -5.78 -0.33 2.14e-8 Hepatitis; CESC cis rs2073300 0.609 rs1936011 chr20:23341912 G/C cg16736954 chr20:23401023 NAPB 0.79 5.96 0.34 7.88e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7100689 0.646 rs10788562 chr10:82072310 C/T cg00277334 chr10:82204260 NA 0.6 8.02 0.44 3.53e-14 Post bronchodilator FEV1; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15241786 chr6:33547978 BAK1 -0.42 -6.47 -0.37 4.79e-10 Fibrinogen levels; CESC cis rs4141404 0.604 rs2103853 chr22:31855475 T/C cg02404636 chr22:31891804 SFI1 0.36 5.06 0.3 7.7e-7 Paclitaxel-induced neuropathy; CESC cis rs61776719 0.520 rs72661887 chr1:38416310 C/T cg04673462 chr1:38461896 NA 0.38 5.85 0.34 1.45e-8 Coronary artery disease; CESC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs9300255 0.596 rs7304782 chr12:123719444 A/G cg05973401 chr12:123451056 ABCB9 -0.46 -5.61 -0.33 5.05e-8 Neutrophil percentage of white cells; CESC cis rs761746 0.960 rs7289075 chr22:32013745 T/C cg25791279 chr22:32026902 PISD 0.57 6.69 0.38 1.33e-10 Intelligence; CESC cis rs36051895 0.623 rs11506293 chr9:5257430 A/G cg02405213 chr9:5042618 JAK2 -0.49 -5.58 -0.32 6.02e-8 Pediatric autoimmune diseases; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23359706 chr19:11491839 EPOR 0.47 6.11 0.35 3.55e-9 Gut microbiota (bacterial taxa); CESC cis rs6800768 0.593 rs11129139 chr3:24146298 C/G cg10674438 chr3:24145617 LOC152024 -0.46 -6.29 -0.36 1.34e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11677416 0.961 rs3783557 chr2:113530712 C/T cg27083787 chr2:113543245 IL1A 0.66 7.51 0.42 9.29e-13 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg07157834 chr1:205819609 PM20D1 0.44 6.46 0.37 5.07e-10 Menarche (age at onset); CESC cis rs7429990 0.930 rs7374516 chr3:48002640 T/C cg11946769 chr3:48343235 NME6 0.44 5.28 0.31 2.7e-7 Educational attainment (years of education); CESC cis rs854765 0.547 rs2955384 chr17:17939573 C/T cg16928487 chr17:17741425 SREBF1 -0.5 -8.45 -0.46 2e-15 Total body bone mineral density; CESC cis rs7264396 0.623 rs2590984 chr20:34597031 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.69 -8.73 -0.47 2.94e-16 Total cholesterol levels; CESC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg19592336 chr6:28129416 ZNF389 0.53 6.78 0.38 7.77e-11 Parkinson's disease; CESC cis rs7296418 0.961 rs949143 chr12:123595163 G/A cg00376283 chr12:123451042 ABCB9 0.74 10.87 0.56 5.16e-23 Platelet count; CESC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg07701084 chr6:150067640 NUP43 0.47 6.62 0.38 1.97e-10 Lung cancer; CESC cis rs477692 0.544 rs7894836 chr10:131442595 T/A cg05714579 chr10:131428358 MGMT -0.68 -9.61 -0.51 6.06e-19 Response to temozolomide; CESC cis rs7216064 1.000 rs7209675 chr17:65831258 A/T cg12091567 chr17:66097778 LOC651250 -0.78 -8.84 -0.48 1.33e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7512552 0.809 rs9436112 chr1:150406449 A/C cg15654264 chr1:150340011 RPRD2 0.4 5.3 0.31 2.4e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs6088580 0.634 rs4911422 chr20:32999345 T/C cg06115741 chr20:33292138 TP53INP2 -0.46 -5.98 -0.34 7.28e-9 Glomerular filtration rate (creatinine); CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg16145915 chr7:1198662 ZFAND2A -0.54 -6.68 -0.38 1.42e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11249608 0.789 rs1969025 chr5:178425192 A/G cg01312482 chr5:178451176 ZNF879 -0.39 -5.2 -0.3 3.94e-7 Pubertal anthropometrics; CESC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Depression; CESC cis rs12291225 0.585 rs11023197 chr11:14380998 G/A cg19336497 chr11:14380999 RRAS2 -0.44 -6.56 -0.37 2.85e-10 Sense of smell; CESC cis rs9868809 0.772 rs9811318 chr3:48702606 A/G cg06212747 chr3:49208901 KLHDC8B -0.62 -5.36 -0.31 1.82e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC trans rs9951602 0.833 rs9953548 chr18:76640601 C/T cg02800362 chr5:177631904 HNRNPAB 0.6 6.48 0.37 4.49e-10 Obesity-related traits; CESC cis rs1801251 0.644 rs283473 chr2:233654847 A/G cg25237894 chr2:233734115 C2orf82 0.36 6.16 0.35 2.74e-9 Coronary artery disease; CESC cis rs5769765 0.865 rs9616369 chr22:50304591 A/C cg26441486 chr22:50317300 CRELD2 0.4 5.38 0.31 1.64e-7 Schizophrenia; CESC cis rs1670533 0.932 rs9992925 chr4:1050909 A/T cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.77e-7 Recombination rate (females); CESC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg02462569 chr6:150064036 NUP43 -0.34 -5.06 -0.3 7.74e-7 Lung cancer; CESC cis rs854765 0.663 rs1108648 chr17:17750558 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.5 -6.88 -0.39 4.36e-11 Total body bone mineral density; CESC cis rs1009170 0.794 rs61988399 chr14:92581494 T/C cg10324096 chr14:92587714 CPSF2;NDUFB1 0.54 5.07 0.3 7.38e-7 Dialysis-related mortality; CESC cis rs1153858 1.000 rs8032904 chr15:45651309 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.27e-9 Homoarginine levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05537210 chr4:110650914 PLA2G12A -0.46 -6.69 -0.38 1.34e-10 Fibrinogen levels; CESC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.59 0.64 2.72e-32 Prudent dietary pattern; CESC cis rs4629180 1.000 rs4851457 chr2:102091220 C/T cg04415270 chr2:102091202 RFX8 0.46 7.33 0.41 2.73e-12 Chronic rhinosinusitis with nasal polyps; CESC cis rs62458065 0.513 rs7805536 chr7:32573570 T/C cg20159608 chr7:32802032 NA -0.55 -6.16 -0.35 2.74e-9 Metabolite levels (HVA/MHPG ratio); CESC cis rs1878931 0.501 rs9921169 chr16:3421261 A/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.72 9.58 0.51 7.24e-19 Body mass index (adult); CESC cis rs6121246 0.909 rs6089071 chr20:30378384 C/G cg13852791 chr20:30311386 BCL2L1 0.84 9.06 0.49 2.91e-17 Mean corpuscular hemoglobin; CESC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg07677032 chr17:61819896 STRADA 0.42 5.36 0.31 1.78e-7 Height; CESC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg07870213 chr5:140052090 DND1 0.61 6.65 0.38 1.67e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs738322 0.967 rs132985 chr22:38563471 C/T cg17652424 chr22:38574118 PLA2G6 -0.32 -5.65 -0.33 4.22e-8 Cutaneous nevi; CESC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg00149659 chr3:10157352 C3orf10 0.73 8.83 0.48 1.44e-16 Alzheimer's disease; CESC cis rs2228479 0.850 rs2238531 chr16:89856217 C/G cg04013166 chr16:89971882 TCF25 0.78 6.67 0.38 1.44e-10 Skin colour saturation; CESC cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg05535760 chr7:792225 HEATR2 0.88 11.01 0.56 1.78e-23 Cerebrospinal P-tau181p levels; CESC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg19318889 chr4:1322082 MAEA 0.46 6.33 0.36 1.04e-9 Longevity; CESC cis rs3733585 0.699 rs4515163 chr4:9959603 C/T cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg05535760 chr7:792225 HEATR2 -0.77 -8.08 -0.44 2.33e-14 Cerebrospinal P-tau181p levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01698708 chr1:28100000 STX12 0.51 6.65 0.38 1.64e-10 Gut microbiota (bacterial taxa); CESC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg27427491 chr17:78079615 GAA 0.4 5.75 0.33 2.52e-8 Yeast infection; CESC cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs34779708 0.966 rs2045918 chr10:35418517 T/G cg04310649 chr10:35416472 CREM -0.5 -6.04 -0.35 5.26e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.51e-7 Life satisfaction; CESC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg18402987 chr7:1209562 NA 0.65 6.69 0.38 1.36e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1707322 0.785 rs10890348 chr1:46242423 G/T cg03146154 chr1:46216737 IPP 0.81 11.14 0.56 6.92e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27402845 chr11:1000533 AP2A2 0.52 7.29 0.41 3.61e-12 Fibrinogen levels; CESC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg16743903 chr16:89593216 SPG7 -0.42 -5.4 -0.32 1.45e-7 Multiple myeloma (IgH translocation); CESC cis rs9549260 0.755 rs7986407 chr13:41179798 A/G cg21288729 chr13:41239152 FOXO1 0.61 7.5 0.42 9.83e-13 Red blood cell count; CESC cis rs9322193 0.639 rs4869756 chr6:150207496 G/A cg01145232 chr6:150245071 RAET1G 0.5 6.24 0.36 1.75e-9 Lung cancer; CESC trans rs2727020 0.521 rs4980445 chr11:49570183 C/T cg15704280 chr7:45808275 SEPT13 -0.85 -10.47 -0.54 1.08e-21 Coronary artery disease; CESC cis rs672059 0.513 rs627064 chr1:183165716 C/T cg05929019 chr1:183155154 LAMC2 -0.29 -5.37 -0.31 1.71e-7 Hypertriglyceridemia; CESC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg08470875 chr2:26401718 FAM59B 0.58 6.07 0.35 4.29e-9 Gut microbiome composition (summer); CESC trans rs208520 0.690 rs12209753 chr6:66703951 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.6 0.61 7.7e-29 Exhaled nitric oxide output; CESC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg14893161 chr1:205819251 PM20D1 -0.74 -12.94 -0.62 5.19e-30 Monocyte percentage of white cells; CESC cis rs6121246 0.529 rs6058196 chr20:30194714 A/T cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC trans rs1814175 0.559 rs1818892 chr11:49863084 C/A cg03929089 chr4:120376271 NA -0.9 -14.75 -0.67 2.44e-36 Height; CESC cis rs4654899 0.833 rs10916919 chr1:21317524 A/G cg05370193 chr1:21551575 ECE1 -0.42 -6.46 -0.37 5.05e-10 Superior frontal gyrus grey matter volume; CESC cis rs1348850 0.526 rs6433672 chr2:178378175 G/T cg23306229 chr2:178417860 TTC30B 0.75 6.84 0.39 5.47e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9457247 1.000 rs386548 chr6:167385533 A/T cg25258033 chr6:167368657 RNASET2 -0.38 -5.69 -0.33 3.39e-8 Crohn's disease; CESC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.43 0.32 1.25e-7 Electroencephalogram traits; CESC cis rs3796352 1.000 rs71301809 chr3:53090312 C/T cg07884673 chr3:53033167 SFMBT1 0.68 5.79 0.34 1.99e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs6582630 0.593 rs7134006 chr12:38596245 A/C cg13010199 chr12:38710504 ALG10B 0.53 6.8 0.39 6.93e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs2985684 1.000 rs1952012 chr14:50098896 T/A cg15316458 chr14:50087796 RPL36AL;MGAT2 0.45 5.15 0.3 4.99e-7 Carotid intima media thickness; CESC cis rs12956009 0.583 rs11082575 chr18:44905068 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.48 -5.85 -0.34 1.46e-8 Educational attainment (years of education); CESC cis rs11958404 0.932 rs6870420 chr5:157437166 T/C cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs55871839 0.708 rs1448541 chr8:59812938 G/A cg07426533 chr8:59803705 TOX -0.47 -7.01 -0.4 1.95e-11 Pneumonia; CESC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg26839252 chr6:160211577 TCP1;MRPL18 0.49 6.15 0.35 2.83e-9 Age-related macular degeneration (geographic atrophy); CESC cis rs6570726 0.935 rs376991 chr6:145828073 G/C cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.3 0.31 2.39e-7 Menopause (age at onset); CESC cis rs6088580 0.634 rs4911153 chr20:32961547 C/T cg24642439 chr20:33292090 TP53INP2 -0.52 -6.78 -0.38 7.87e-11 Glomerular filtration rate (creatinine); CESC cis rs7903847 0.642 rs4635018 chr10:99137839 C/G cg20016023 chr10:99160130 RRP12 0.32 5.17 0.3 4.61e-7 Granulocyte percentage of myeloid white cells; CESC trans rs8073060 0.544 rs225287 chr17:33929487 G/T cg19694781 chr19:47549865 TMEM160 -0.72 -6.86 -0.39 4.73e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs7605827 0.930 rs722327 chr2:15657263 T/A cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.65e-10 Educational attainment (years of education); CESC cis rs7107174 1.000 rs4944198 chr11:78032605 T/A cg03754400 chr11:77348600 CLNS1A 0.45 5.15 0.3 5.15e-7 Testicular germ cell tumor; CESC cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg15017067 chr4:17643749 FAM184B 0.37 5.18 0.3 4.34e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7208859 0.623 rs7223404 chr17:29107363 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10883723 0.810 rs7912901 chr10:104277440 T/C cg22532475 chr10:104410764 TRIM8 -0.33 -5.67 -0.33 3.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7246657 0.943 rs7248733 chr19:37996361 A/C cg23950597 chr19:37808831 NA -0.51 -5.73 -0.33 2.73e-8 Coronary artery calcification; CESC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg04944784 chr2:26401820 FAM59B 0.61 7.12 0.4 1.01e-11 Gut microbiome composition (summer); CESC cis rs9902453 0.904 rs4567782 chr17:28268800 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 9.16 0.49 1.49e-17 Coffee consumption (cups per day); CESC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg10691866 chr7:65817282 TPST1 0.33 5.52 0.32 8.14e-8 Aortic root size; CESC cis rs7520050 0.898 rs4660885 chr1:46243756 C/T cg03146154 chr1:46216737 IPP -0.51 -6.64 -0.38 1.76e-10 Red blood cell count;Reticulocyte count; CESC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg12412775 chr1:25698385 RHCE -0.31 -5.59 -0.32 5.76e-8 Erythrocyte sedimentation rate; CESC trans rs17307778 1.000 rs1425830 chr11:25356679 G/A cg22888484 chr20:37075185 SNHG11 -0.64 -6.22 -0.36 1.97e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg21918786 chr6:109611834 NA -0.4 -6.07 -0.35 4.46e-9 Reticulocyte fraction of red cells; CESC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC trans rs60843830 1.000 rs114976176 chr2:264621 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 8.22 0.45 9.37e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7659604 0.540 rs9995322 chr4:122675642 G/A cg19671926 chr4:122722719 EXOSC9 0.53 6.7 0.38 1.21e-10 Type 2 diabetes; CESC cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg24818145 chr4:99064322 C4orf37 0.4 5.05 0.3 8.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7659604 0.628 rs3828485 chr4:122722368 G/A cg06713675 chr4:122721982 EXOSC9 -0.51 -7.07 -0.4 1.37e-11 Type 2 diabetes; CESC cis rs79349575 0.783 rs12602933 chr17:47029280 G/C cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC trans rs10463316 0.744 rs6579869 chr5:150763621 G/A cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg08736216 chr1:53307985 ZYG11A -0.4 -7.14 -0.4 8.92e-12 Monocyte count; CESC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg03467027 chr4:99064603 C4orf37 0.47 5.97 0.34 7.51e-9 Colonoscopy-negative controls vs population controls; CESC cis rs12497850 1.000 rs4858831 chr3:48735558 C/T cg07636037 chr3:49044803 WDR6 0.9 15.33 0.69 2.12e-38 Parkinson's disease; CESC cis rs2637266 0.935 rs2579727 chr10:78395497 A/C cg18941641 chr10:78392320 NA 0.45 8.6 0.47 7.12e-16 Pulmonary function; CESC cis rs11642862 1.000 rs11641321 chr16:30880319 G/A cg02466173 chr16:30829666 NA -0.58 -5.67 -0.33 3.72e-8 Tonsillectomy; CESC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg00149659 chr3:10157352 C3orf10 0.69 8.2 0.45 1.02e-14 Alzheimer's disease; CESC cis rs12136530 0.625 rs4912090 chr1:19749402 C/T cg01832549 chr1:19774989 CAPZB 0.43 6.3 0.36 1.21e-9 Lead levels in blood; CESC trans rs4349753 0.617 rs10061660 chr5:144090021 A/G cg22407458 chr6:35109121 TCP11 0.51 6.45 0.37 5.37e-10 Photic sneeze reflex; CESC cis rs2952156 0.920 rs9675194 chr17:37833805 A/G cg19468946 chr17:37922297 IKZF3 -0.44 -5.88 -0.34 1.24e-8 Asthma; CESC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg26338869 chr17:61819248 STRADA -0.7 -9.29 -0.5 5.69e-18 Prudent dietary pattern; CESC cis rs7072216 0.726 rs4474372 chr10:100164571 C/T cg26618903 chr10:100175079 PYROXD2 -0.35 -5.33 -0.31 2.1e-7 Metabolite levels; CESC trans rs884127 0.744 rs13374441 chr1:220073531 C/G cg18635631 chr12:718175 NINJ2 0.49 6.08 0.35 4.07e-9 Urinary electrolytes (magnesium/calcium ratio); CESC cis rs2011503 1.000 rs45556231 chr19:19654189 G/A cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs9287719 0.781 rs12472807 chr2:10781605 G/A cg02196655 chr2:10830764 NOL10 -0.37 -5.66 -0.33 3.93e-8 Prostate cancer; CESC cis rs4253772 0.591 rs739165 chr22:46684528 C/T cg10541313 chr22:46663664 TTC38 0.76 5.66 0.33 3.95e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7914558 1.000 rs7071373 chr10:104771922 A/G cg15744005 chr10:104629667 AS3MT -0.33 -5.5 -0.32 9.16e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.13 0.3 5.72e-7 Menopause (age at onset); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg14640751 chr11:111636595 PPP2R1B 0.47 6.28 0.36 1.38e-9 Systemic lupus erythematosus; CESC cis rs854765 0.647 rs854763 chr17:18010095 C/G cg04398451 chr17:18023971 MYO15A -0.77 -11.15 -0.57 6.08e-24 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26057283 chr7:73082469 VPS37D -0.44 -6.23 -0.36 1.83e-9 Fibrinogen levels; CESC cis rs9584850 0.834 rs12463 chr13:99105302 G/A cg22223119 chr13:99095684 FARP1 -0.36 -5.21 -0.31 3.73e-7 Neuroticism; CESC cis rs2228479 0.850 rs11647174 chr16:89958538 G/A cg14709524 chr16:89940631 TCF25 0.87 6.44 0.37 5.45e-10 Skin colour saturation; CESC cis rs144345632 1 rs144345632 chr6:96886894 T/TA cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Facial morphology (factor 17, height of vermillion upper lip); CESC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg02187348 chr16:89574699 SPG7 0.65 9.14 0.49 1.67e-17 Multiple myeloma (IgH translocation); CESC cis rs10992471 0.598 rs2025389 chr9:95157674 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.4 5.04 0.3 8.5e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs894344 0.584 rs2028556 chr8:135648040 T/C cg27224718 chr8:135614730 ZFAT 0.42 5.48 0.32 9.71e-8 Systolic blood pressure; CESC cis rs6460942 0.908 rs73677573 chr7:12283598 G/A cg06484146 chr7:12443880 VWDE -0.57 -6.01 -0.35 6.03e-9 Coronary artery disease; CESC cis rs2228479 0.850 rs62054640 chr16:89823157 C/T cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs12476592 0.543 rs262470 chr2:63830559 C/T cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC cis rs3785574 0.743 rs2727334 chr17:61969063 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.75 9.58 0.51 7.43e-19 Height; CESC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg22535103 chr8:58192502 C8orf71 -0.92 -10.16 -0.53 1.04e-20 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02729269 chr16:127772 MPG 0.4 6.0 0.35 6.46e-9 Gut microbiota (bacterial taxa); CESC cis rs2302190 0.882 rs8073754 chr17:56618030 C/T cg25885038 chr17:56607967 SEPT4 -0.42 -5.68 -0.33 3.52e-8 Vitamin D levels; CESC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.07 10.37 0.54 2.23e-21 Platelet count; CESC cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg23583168 chr7:148888333 NA -0.74 -10.71 -0.55 1.73e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07784212 chr3:47554384 C3orf75 -0.58 -6.52 -0.37 3.52e-10 Gut microbiome composition (summer); CESC cis rs6539267 0.748 rs1921953 chr12:106721012 C/T cg00173435 chr12:106696525 TCP11L2 0.51 6.0 0.35 6.6e-9 Tourette syndrome; CESC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg23758822 chr17:41437982 NA 1.03 15.5 0.69 5.3e-39 Menopause (age at onset); CESC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg24549020 chr5:56110836 MAP3K1 0.65 7.53 0.42 7.9e-13 Initial pursuit acceleration; CESC cis rs9929218 0.953 rs34909703 chr16:68740097 T/C cg02972257 chr16:68554789 NA 0.56 6.47 0.37 4.69e-10 Colorectal cancer; CESC cis rs933688 1.000 rs2052553 chr5:90729906 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 1.01 13.73 0.64 8.84e-33 Smoking behavior; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00884529 chr7:16685823 BZW2;ANKMY2 -0.45 -6.78 -0.38 7.64e-11 Gambling; CESC cis rs9487051 0.676 rs1521905 chr6:109594515 T/C cg21918786 chr6:109611834 NA -0.37 -5.41 -0.32 1.39e-7 Reticulocyte fraction of red cells; CESC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.56 0.37 2.79e-10 Bipolar disorder; CESC cis rs2481665 1.000 rs2481665 chr1:62594677 T/C cg18591186 chr1:62594603 INADL -0.6 -7.1 -0.4 1.13e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs8072100 0.840 rs11079774 chr17:45479706 C/G cg08085267 chr17:45401833 C17orf57 -0.53 -7.1 -0.4 1.13e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20459655 chr2:135675569 CCNT2 -0.41 -6.03 -0.35 5.56e-9 Gut microbiota (bacterial taxa); CESC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg19592336 chr6:28129416 ZNF389 0.61 8.25 0.45 7.45e-15 Depression; CESC cis rs12541635 0.677 rs1817939 chr8:107029820 A/G cg10147462 chr8:107024639 NA 0.47 7.14 0.4 8.95e-12 Age of smoking initiation; CESC cis rs9300255 0.602 rs1790095 chr12:123681222 G/A cg00376283 chr12:123451042 ABCB9 0.71 8.76 0.47 2.39e-16 Neutrophil percentage of white cells; CESC cis rs2267137 0.776 rs2267145 chr22:29805407 C/T cg07256473 chr22:29710276 RASL10A -0.38 -5.53 -0.32 7.55e-8 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs9916302 0.904 rs8065963 chr17:37681332 C/T cg20243544 chr17:37824526 PNMT 0.52 6.58 0.37 2.56e-10 Glomerular filtration rate (creatinine); CESC cis rs7250872 0.647 rs2304612 chr19:1817866 A/G cg05970437 chr19:1864622 KLF16 -0.47 -5.57 -0.32 6.26e-8 Bipolar disorder; CESC cis rs28830936 1.000 rs17734856 chr15:42045160 T/C cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.42 -5.86 -0.34 1.39e-8 Diastolic blood pressure; CESC cis rs17253792 0.822 rs118027213 chr14:56039076 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.73 0.33 2.76e-8 Putamen volume; CESC cis rs6541297 1.000 rs11122405 chr1:230282997 C/A cg20703242 chr1:230279135 GALNT2 0.73 11.17 0.57 5.58e-24 Coronary artery disease; CESC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg04414720 chr1:150670196 GOLPH3L 0.58 7.57 0.42 6.07e-13 Melanoma; CESC cis rs9911578 1.000 rs9901181 chr17:56964271 C/T cg12560992 chr17:57184187 TRIM37 0.94 15.62 0.69 1.92e-39 Intelligence (multi-trait analysis); CESC cis rs12541635 0.677 rs10086055 chr8:107024129 C/T cg10147462 chr8:107024639 NA 0.43 6.45 0.37 5.42e-10 Age of smoking initiation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27405321 chr20:34359917 PHF20 -0.42 -6.08 -0.35 4.23e-9 Gut microbiota (bacterial taxa); CESC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.41 6.74 0.38 9.73e-11 Personality dimensions; CESC cis rs1018836 0.851 rs6986359 chr8:91643162 A/G cg16814680 chr8:91681699 NA -0.71 -10.7 -0.55 1.89e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs921968 0.643 rs711191 chr2:219386084 T/A cg02176678 chr2:219576539 TTLL4 0.43 7.74 0.43 2.13e-13 Mean corpuscular hemoglobin concentration; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg23709988 chr14:23772096 PPP1R3E -0.42 -6.34 -0.36 9.84e-10 Breast cancer; CESC trans rs6089829 0.926 rs1060489 chr20:61665921 C/T cg23505145 chr19:12996616 KLF1 0.52 6.82 0.39 6.11e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs748404 0.578 rs507178 chr15:43610135 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.75 0.47 2.5e-16 Lung cancer; CESC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg02071572 chr4:1403502 NA 0.38 5.51 0.32 8.58e-8 Longevity; CESC cis rs2522056 0.808 rs7704457 chr5:131744790 C/T cg24060327 chr5:131705240 SLC22A5 -0.62 -6.84 -0.39 5.55e-11 Lymphocyte counts;Fibrinogen; CESC cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 3.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg16447950 chr5:562315 NA -0.58 -6.05 -0.35 4.93e-9 Lung disease severity in cystic fibrosis; CESC cis rs3857067 0.806 rs2865343 chr4:95103005 C/T cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.07 -0.49 2.67e-17 QT interval; CESC cis rs2635047 0.904 rs2635046 chr18:44728429 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.06 0.35 4.58e-9 Educational attainment; CESC cis rs5758659 0.652 rs133314 chr22:42401841 G/A cg15557168 chr22:42548783 NA -0.42 -6.17 -0.35 2.52e-9 Cognitive function; CESC cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg05340658 chr4:99064831 C4orf37 0.77 11.6 0.58 2.01e-25 Colonoscopy-negative controls vs population controls; CESC cis rs9549367 0.756 rs2302756 chr13:113900197 G/A cg00898013 chr13:113819073 PROZ 0.54 7.48 0.42 1.09e-12 Platelet distribution width; CESC cis rs763014 0.966 rs15564 chr16:677854 G/T cg00802000 chr16:706648 WDR90 -0.4 -6.15 -0.35 2.8e-9 Height; CESC cis rs4601790 0.601 rs12801636 chr11:65391317 C/T cg21033440 chr11:65409861 SIPA1 -0.41 -5.37 -0.31 1.74e-7 Blood pressure (age interaction); CESC cis rs3126085 0.935 rs2338430 chr1:152214420 C/T cg03465714 chr1:152285911 FLG 0.42 5.09 0.3 6.89e-7 Atopic dermatitis; CESC trans rs3942852 0.622 rs6485806 chr11:48102806 A/G cg15704280 chr7:45808275 SEPT13 0.63 7.54 0.42 7.59e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg20307385 chr11:47447363 PSMC3 -0.65 -7.78 -0.43 1.67e-13 Subjective well-being; CESC cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg06212747 chr3:49208901 KLHDC8B 0.74 9.74 0.51 2.27e-19 Parkinson's disease; CESC cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg01475377 chr6:109611718 NA -0.52 -8.68 -0.47 4.14e-16 Reticulocyte fraction of red cells; CESC cis rs9929218 0.954 rs7186333 chr16:68815838 T/A cg02972257 chr16:68554789 NA 0.47 5.85 0.34 1.42e-8 Colorectal cancer; CESC cis rs6087771 0.662 rs6058298 chr20:30247916 C/T cg13852791 chr20:30311386 BCL2L1 0.77 9.79 0.52 1.66e-19 Subcortical brain region volumes;Putamen volume; CESC cis rs6582630 0.576 rs2387837 chr12:38403164 G/T cg26384229 chr12:38710491 ALG10B -0.46 -6.2 -0.36 2.14e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs936229 0.651 rs12908814 chr15:75132490 C/G cg14664628 chr15:75095509 CSK -0.55 -7.24 -0.41 5.01e-12 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg06481639 chr22:41940642 POLR3H -0.61 -6.46 -0.37 4.88e-10 Vitiligo; CESC cis rs11077998 0.967 rs7350963 chr17:80491067 G/A cg10255544 chr17:80519551 FOXK2 0.55 8.94 0.48 6.67e-17 Reticulocyte fraction of red cells; CESC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.88 13.32 0.63 2.41e-31 Prudent dietary pattern; CESC cis rs1536827 0.841 rs10857733 chr10:135332803 G/A cg18984983 chr10:135342936 CYP2E1 0.54 5.43 0.32 1.3e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs6942756 0.876 rs822040 chr7:129065922 C/G cg02491457 chr7:128862824 NA 0.51 6.93 0.39 3.16e-11 White matter hyperintensity burden; CESC cis rs10504073 0.669 rs341801 chr8:50037784 A/G cg00325661 chr8:49890786 NA 0.5 7.28 0.41 3.89e-12 Blood metabolite ratios; CESC cis rs17125944 0.505 rs76219229 chr14:53178346 G/A cg13660082 chr14:53194042 PSMC6 -0.64 -5.97 -0.34 7.46e-9 Alzheimer's disease (late onset); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07080049 chr9:96214194 FAM120A;FAM120AOS 0.52 6.85 0.39 5.22e-11 Systemic lupus erythematosus; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg07519011 chr13:76056421 TBC1D4 0.46 6.14 0.35 3.06e-9 Myopia (pathological); CESC cis rs72781680 0.752 rs72796110 chr2:23905658 T/A cg20701182 chr2:24300061 SF3B14 0.79 6.83 0.39 5.68e-11 Lymphocyte counts; CESC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg23758822 chr17:41437982 NA 1.0 14.95 0.68 4.7e-37 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12508534 chr6:34855789 TAF11;ANKS1A 0.67 7.94 0.44 5.62e-14 Gut microbiome composition (summer); CESC cis rs10751667 0.666 rs10902239 chr11:946484 A/G cg06064525 chr11:970664 AP2A2 0.48 9.46 0.5 1.78e-18 Alzheimer's disease (late onset); CESC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg07701084 chr6:150067640 NUP43 0.42 5.88 0.34 1.21e-8 Lung cancer; CESC cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg03467027 chr4:99064603 C4orf37 0.48 5.98 0.35 7.05e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1483890 0.723 rs13075664 chr3:69411365 G/A cg22125112 chr3:69402811 FRMD4B 0.39 5.24 0.31 3.3e-7 Resting heart rate; CESC cis rs11122272 0.735 rs11122280 chr1:231519816 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -7.21 -0.4 5.96e-12 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18960028 chr11:75526075 UVRAG 0.55 6.47 0.37 4.59e-10 Gut microbiome composition (summer); CESC cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg21573476 chr21:45109991 RRP1B -0.45 -6.28 -0.36 1.34e-9 Mean corpuscular volume; CESC cis rs9611565 0.559 rs1006407 chr22:41972032 T/C cg06481639 chr22:41940642 POLR3H -0.68 -6.74 -0.38 9.96e-11 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08369870 chr16:70323412 AARS -0.54 -6.57 -0.37 2.63e-10 Gut microbiome composition (summer); CESC trans rs875971 0.638 rs7793569 chr7:66116633 T/G cg26939375 chr7:64535504 NA -0.64 -8.57 -0.47 8.53e-16 Aortic root size; CESC cis rs1832871 0.672 rs6933928 chr6:158747071 C/T cg07165851 chr6:158734300 TULP4 0.59 6.41 0.37 6.63e-10 Height; CESC cis rs11608355 0.515 rs11613718 chr12:109912332 C/T cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs7833986 0.501 rs17814658 chr8:56989130 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.54 0.42 7.58e-13 Height; CESC cis rs4409675 0.576 rs7535816 chr1:28234054 A/G cg23691781 chr1:28212827 C1orf38 0.28 5.45 0.32 1.17e-7 Corneal astigmatism; CESC cis rs763121 0.853 rs5750630 chr22:38985818 A/C cg06544989 chr22:39130855 UNC84B 0.5 8.31 0.45 5.07e-15 Menopause (age at onset); CESC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg27170947 chr2:26402098 FAM59B -0.7 -8.2 -0.45 1.05e-14 Gut microbiome composition (summer); CESC cis rs6060717 0.536 rs6058356 chr20:34491530 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -6.2 -0.36 2.13e-9 Hip circumference adjusted for BMI; CESC cis rs2302190 0.769 rs8082396 chr17:56632193 C/T cg25885038 chr17:56607967 SEPT4 -0.41 -5.38 -0.31 1.63e-7 Vitamin D levels; CESC cis rs6519955 0.860 rs8136098 chr22:46425646 A/G cg05468064 chr22:46423449 NA 0.44 7.07 0.4 1.34e-11 Dupuytren's disease; CESC cis rs1878931 0.501 rs17136359 chr16:3420814 C/T cg22508957 chr16:3507546 NAT15 0.39 5.66 0.33 3.92e-8 Body mass index (adult); CESC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.17 0.4 7.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11822910 0.737 rs2581924 chr11:57208468 C/T cg00522883 chr11:57194120 SLC43A3 0.54 6.93 0.39 3.28e-11 Platelet distribution width; CESC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.7 0.43 2.77e-13 Prudent dietary pattern; CESC cis rs4132509 1.000 rs4132509 chr1:243943084 A/C cg21452805 chr1:244014465 NA -0.54 -6.7 -0.38 1.26e-10 RR interval (heart rate); CESC trans rs561341 1.000 rs55978022 chr17:30275937 T/C cg27661571 chr11:113659931 NA -0.88 -8.06 -0.44 2.59e-14 Hip circumference adjusted for BMI; CESC cis rs4862750 0.872 rs7664463 chr4:187876686 A/C cg03647317 chr4:187891568 NA -0.44 -6.55 -0.37 3.01e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03217964 chr16:75182191 ZFP1 -0.45 -6.57 -0.37 2.6200000000000003e-10 Gambling; CESC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.93 14.13 0.66 3.66e-34 Prudent dietary pattern; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02238950 chr17:1505303 SLC43A2 0.46 6.25 0.36 1.65e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs763014 0.931 rs7192508 chr16:630367 C/T cg07256732 chr16:621771 PIGQ -0.3 -5.13 -0.3 5.63e-7 Height; CESC cis rs656900 0.874 rs584055 chr15:80126521 A/T cg02196730 chr15:80188777 MTHFS -0.42 -5.44 -0.32 1.19e-7 Cerebrospinal P-tau181p levels; CESC cis rs6912958 0.512 rs910563 chr6:88058885 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.81 0.55 8.16e-23 Monocyte percentage of white cells; CESC cis rs782590 0.774 rs782630 chr2:55899425 T/C cg18811423 chr2:55921094 PNPT1 0.78 12.9 0.62 7e-30 Metabolic syndrome; CESC cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg13722127 chr7:150037890 RARRES2 -0.36 -5.46 -0.32 1.09e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs7631605 0.905 rs7622170 chr3:37016576 T/C cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.09 -0.3 6.91e-7 Cerebrospinal P-tau181p levels; CESC cis rs10752881 1.000 rs12035773 chr1:182985716 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.79e-31 Colorectal cancer; CESC cis rs6540556 0.954 rs654984 chr1:209937382 C/T cg05527609 chr1:210001259 C1orf107 0.51 6.44 0.37 5.46e-10 Red blood cell count; CESC cis rs4969178 0.965 rs938350 chr17:76399552 C/T cg20026190 chr17:76395443 PGS1 0.47 7.44 0.42 1.45e-12 HDL cholesterol levels; CESC cis rs3820068 0.705 rs57440988 chr1:15879034 T/C cg18192808 chr1:15853278 DNAJC16 0.44 5.34 0.31 2.03e-7 Systolic blood pressure; CESC cis rs7107174 1.000 rs2512547 chr11:77960888 T/C cg02023728 chr11:77925099 USP35 0.43 5.97 0.34 7.44e-9 Testicular germ cell tumor; CESC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg08859206 chr1:53392774 SCP2 -0.54 -7.25 -0.41 4.66e-12 Monocyte count; CESC cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg23711669 chr6:146136114 FBXO30 -1.03 -15.36 -0.69 1.63e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs7208859 0.673 rs9895815 chr17:29138033 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs920590 0.758 rs7011322 chr8:19661937 C/T cg03894339 chr8:19674705 INTS10 0.63 7.26 0.41 4.24e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg25517755 chr10:38738941 LOC399744 -0.47 -6.04 -0.35 5.12e-9 Extrinsic epigenetic age acceleration; CESC cis rs7666738 0.618 rs10856932 chr4:98819992 C/T cg05340658 chr4:99064831 C4orf37 0.73 10.49 0.54 9.13e-22 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg27535305 chr1:53392650 SCP2 -0.33 -5.57 -0.32 6.32e-8 Monocyte count; CESC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.83 8.32 0.46 4.56e-15 Platelet count; CESC cis rs4132509 1.000 rs10927078 chr1:243983830 C/T cg21452805 chr1:244014465 NA 0.5 5.65 0.33 4.07e-8 RR interval (heart rate); CESC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC trans rs722599 0.748 rs61978948 chr14:75363369 G/A cg00095594 chr1:236228625 NID1 -0.4 -6.14 -0.35 2.93e-9 IgG glycosylation; CESC cis rs8028182 0.636 rs8028277 chr15:75684085 A/G cg20655648 chr15:75932815 IMP3 0.46 5.85 0.34 1.41e-8 Sudden cardiac arrest; CESC trans rs11191205 0.644 rs3095791 chr10:103383836 T/C cg12418535 chr2:119607192 EN1 -0.4 -6.0 -0.35 6.56e-9 Intelligence (multi-trait analysis); CESC cis rs7666738 0.512 rs6532704 chr4:98777562 C/T cg05340658 chr4:99064831 C4orf37 0.52 6.88 0.39 4.36e-11 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 1.000 rs2531729 chr17:56539890 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.41 5.41 0.32 1.38e-7 Intelligence (multi-trait analysis); CESC cis rs7615952 0.932 rs13321217 chr3:125631771 G/A cg05084668 chr3:125655381 ALG1L -0.42 -5.13 -0.3 5.73e-7 Blood pressure (smoking interaction); CESC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg22535103 chr8:58192502 C8orf71 -1.08 -13.7 -0.64 1.19e-32 Developmental language disorder (linguistic errors); CESC cis rs12477438 0.501 rs6708878 chr2:99801564 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.75 12.51 0.61 1.6e-28 Chronic sinus infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06876404 chr16:30941527 FBXL19 0.5 6.51 0.37 3.66e-10 Fibrinogen levels; CESC cis rs9583531 0.600 rs4773240 chr13:111360585 G/A cg24331049 chr13:111365604 ING1 0.75 10.98 0.56 2.28e-23 Coronary artery disease; CESC cis rs2932538 0.922 rs2932535 chr1:113201412 G/C cg22162597 chr1:113214053 CAPZA1 -0.58 -7.44 -0.42 1.39e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs6087990 0.735 rs6119946 chr20:31329704 A/G cg13636640 chr20:31349939 DNMT3B -0.76 -12.2 -0.6 1.75e-27 Ulcerative colitis; CESC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg21782813 chr7:2030301 MAD1L1 0.4 5.72 0.33 2.89e-8 Schizophrenia; CESC cis rs9902453 0.967 rs3813034 chr17:28524804 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.85 0.43 1.01e-13 Coffee consumption (cups per day); CESC trans rs62103177 0.810 rs62103191 chr18:77628769 C/G cg05926928 chr17:57297772 GDPD1 1.18 10.14 0.53 1.27e-20 Opioid sensitivity; CESC cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg05340658 chr4:99064831 C4orf37 0.76 11.12 0.56 7.61e-24 Colonoscopy-negative controls vs population controls; CESC cis rs2932538 0.922 rs6537745 chr1:113154080 T/C cg22162597 chr1:113214053 CAPZA1 0.5 6.58 0.37 2.52e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs8058578 1.000 rs8048448 chr16:30692208 T/C cg00531865 chr16:30841666 NA -0.44 -5.97 -0.34 7.41e-9 Multiple myeloma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19429466 chr4:87515395 PTPN13 0.56 6.62 0.38 1.94e-10 Gut microbiome composition (summer); CESC cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg24838063 chr12:130822603 PIWIL1 0.64 8.76 0.47 2.33e-16 Menopause (age at onset); CESC cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg18351406 chr4:77819688 ANKRD56 0.49 5.92 0.34 1e-8 Emphysema distribution in smoking; CESC cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs10465746 0.714 rs12730621 chr1:84433745 C/G cg10977910 chr1:84465055 TTLL7 0.52 7.13 0.4 9.46e-12 Obesity-related traits; CESC cis rs9287719 0.967 rs12464817 chr2:10707212 A/G cg00105475 chr2:10696890 NA 0.39 5.71 0.33 3.1e-8 Prostate cancer; CESC cis rs1506636 1.000 rs2896332 chr7:123297223 A/T cg03229431 chr7:123269106 ASB15 -0.53 -6.87 -0.39 4.64e-11 Plateletcrit;Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17928916 chr17:80041824 FASN 0.51 7.22 0.41 5.46e-12 Fibrinogen levels; CESC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg11766577 chr21:47581405 C21orf56 0.45 6.07 0.35 4.4e-9 Testicular germ cell tumor; CESC cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg21926612 chr6:163149169 PACRG;PARK2 -0.81 -8.93 -0.48 7.22e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg18135555 chr8:22132992 PIWIL2 0.24 5.3 0.31 2.47e-7 Hypertriglyceridemia; CESC cis rs57221529 0.766 rs4527146 chr5:555236 A/G cg09021430 chr5:549028 NA -0.43 -5.43 -0.32 1.25e-7 Lung disease severity in cystic fibrosis; CESC cis rs4253772 0.591 rs11703848 chr22:46685131 A/G cg00784671 chr22:46762841 CELSR1 -0.57 -5.5 -0.32 8.75e-8 LDL cholesterol;Cholesterol, total; CESC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg26338869 chr17:61819248 STRADA 0.71 9.3 0.5 5.44e-18 Prudent dietary pattern; CESC cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg02487422 chr3:49467188 NICN1 0.4 5.2 0.3 4.08e-7 Parkinson's disease; CESC cis rs7264396 0.563 rs6060566 chr20:34288226 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.87 0.39 4.47e-11 Total cholesterol levels; CESC cis rs1879734 0.773 rs6658469 chr1:54133345 C/A cg23596471 chr1:54105337 GLIS1 0.38 6.01 0.35 6.05e-9 Mitral valve prolapse; CESC cis rs6831352 0.734 rs2851259 chr4:100033986 C/T cg12011299 chr4:100065546 ADH4 0.57 6.88 0.39 4.34e-11 Alcohol dependence; CESC cis rs6991838 0.556 rs7846527 chr8:66498757 A/G cg13398993 chr8:66546079 ARMC1 -0.48 -5.76 -0.33 2.37e-8 Intelligence (multi-trait analysis); CESC cis rs863345 0.604 rs2873595 chr1:158508382 G/T cg12129480 chr1:158549410 OR10X1 -0.35 -7.03 -0.4 1.78e-11 Pneumococcal bacteremia; CESC cis rs858239 0.537 rs10279691 chr7:23228387 A/G cg23682824 chr7:23144976 KLHL7 0.45 5.85 0.34 1.46e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7917772 0.636 rs4919674 chr10:104522226 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.45 -5.28 -0.31 2.64e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1018836 0.892 rs10103198 chr8:91579436 A/T cg16814680 chr8:91681699 NA -0.59 -8.33 -0.46 4.42e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg16405210 chr4:1374714 KIAA1530 -0.5 -6.29 -0.36 1.33e-9 Obesity-related traits; CESC cis rs7618501 0.699 rs2681781 chr3:49898273 A/G cg24308560 chr3:49941425 MST1R -0.69 -10.31 -0.54 3.58e-21 Intelligence (multi-trait analysis); CESC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs7866350 0.604 rs1935389 chr9:100994470 A/G cg24393316 chr9:100616469 FOXE1 -0.38 -5.53 -0.32 7.66e-8 Post-traumatic stress disorder; CESC cis rs9902453 0.791 rs55655651 chr17:28244286 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.2 0.45 1.05e-14 Coffee consumption (cups per day); CESC cis rs72781680 0.611 rs55868657 chr2:24295385 G/A cg06627628 chr2:24431161 ITSN2 -0.67 -6.48 -0.37 4.54e-10 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26770385 chr8:125486821 RNF139 0.61 6.82 0.39 6.31e-11 Gut microbiome composition (summer); CESC cis rs9399135 0.967 rs10872427 chr6:135353452 T/C cg24558204 chr6:135376177 HBS1L 0.52 7.2 0.4 6.25e-12 Red blood cell count; CESC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg04944784 chr2:26401820 FAM59B -0.74 -8.28 -0.45 6.01e-15 Gut microbiome composition (summer); CESC cis rs11190604 1.000 rs7079756 chr10:102302105 G/A cg07080220 chr10:102295463 HIF1AN 0.56 5.42 0.32 1.35e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs6572548 0.504 rs1956082 chr14:49665496 A/C cg16537350 chr14:50329699 NA -0.55 -6.08 -0.35 4.26e-9 Subjective well-being; CESC cis rs826838 0.967 rs1684415 chr12:39130099 T/C cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs4253772 0.530 rs55653327 chr22:46682976 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.67 5.3 0.31 2.43e-7 LDL cholesterol;Cholesterol, total; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23365392 chr7:99970074 PILRA 0.36 6.41 0.37 6.78e-10 Gut microbiota (bacterial taxa); CESC cis rs9768139 0.708 rs896782 chr7:158114115 G/A cg24154853 chr7:158122151 PTPRN2 0.41 6.43 0.37 5.97e-10 Calcium levels; CESC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg19163074 chr7:65112434 INTS4L2 0.44 5.53 0.32 7.83e-8 Aortic root size; CESC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg21963583 chr11:68658836 MRPL21 0.42 5.72 0.33 2.89e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4835473 0.932 rs13121861 chr4:144735160 C/T cg25736465 chr4:144833511 NA -0.33 -5.35 -0.31 1.92e-7 Immature fraction of reticulocytes; CESC cis rs17376456 0.877 rs17316137 chr5:93456577 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.23 0.31 3.51e-7 Diabetic retinopathy; CESC cis rs36051895 0.623 rs3780383 chr9:5232409 G/C cg02405213 chr9:5042618 JAK2 -0.58 -6.32 -0.36 1.12e-9 Pediatric autoimmune diseases; CESC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 5.16 0.3 4.74e-7 LDL cholesterol;Cholesterol, total; CESC cis rs8180040 0.966 rs6792461 chr3:47473168 C/T cg27129171 chr3:47204927 SETD2 -0.63 -9.64 -0.51 4.95e-19 Colorectal cancer; CESC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg26314531 chr2:26401878 FAM59B 0.7 7.44 0.42 1.42e-12 Gut microbiome composition (summer); CESC cis rs62408225 0.963 rs55885254 chr6:90976234 T/C cg06866423 chr6:90926672 BACH2 0.43 5.18 0.3 4.38e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3026101 0.624 rs1058400 chr17:5288794 G/C cg25236894 chr17:5323110 RPAIN;NUP88 0.39 5.29 0.31 2.51e-7 Body mass index; CESC cis rs863345 0.604 rs1342953 chr1:158464499 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.95 -0.39 2.86e-11 Pneumococcal bacteremia; CESC cis rs4835473 0.868 rs11737787 chr4:144747651 T/C cg25736465 chr4:144833511 NA -0.35 -5.4 -0.32 1.46e-7 Immature fraction of reticulocytes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg00560722 chr10:101989177 CHUK 0.53 7.06 0.4 1.45e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs561341 0.623 rs4795665 chr17:30233657 C/T cg20587970 chr11:113659929 NA -0.64 -8.12 -0.45 1.74e-14 Hip circumference adjusted for BMI; CESC cis rs7084402 0.935 rs893370 chr10:60360834 A/T cg07615347 chr10:60278583 BICC1 0.54 8.25 0.45 7.48e-15 Refractive error; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12043807 chr9:99180432 ZNF367 0.46 6.07 0.35 4.52e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg17178900 chr1:205818956 PM20D1 -0.53 -7.48 -0.42 1.07e-12 Menarche (age at onset); CESC cis rs2760061 0.626 rs634106 chr1:228121548 C/T cg01973587 chr1:228161476 NA 0.36 5.68 0.33 3.54e-8 Diastolic blood pressure; CESC cis rs1707322 1.000 rs785470 chr1:46519622 C/A cg06784218 chr1:46089804 CCDC17 -0.33 -5.65 -0.33 4.08e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2635047 0.638 rs2571006 chr18:44718515 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 5.41 0.32 1.38e-7 Educational attainment; CESC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg26314531 chr2:26401878 FAM59B -0.61 -6.86 -0.39 4.88e-11 Gut microbiome composition (summer); CESC cis rs5750830 0.645 rs756640 chr22:39779300 G/A cg11247378 chr22:39784982 NA -0.52 -8.03 -0.44 3.15e-14 Intelligence (multi-trait analysis); CESC cis rs752010 0.967 rs6675999 chr1:42099024 T/G cg06885757 chr1:42089581 HIVEP3 0.5 8.18 0.45 1.2e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg14061069 chr19:46274453 DMPK 0.53 8.29 0.45 5.9e-15 Coronary artery disease; CESC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs425277 0.565 rs3128293 chr1:2065339 A/G cg24578937 chr1:2090814 PRKCZ -0.36 -6.11 -0.35 3.46e-9 Height; CESC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg10645314 chr2:3704589 ALLC -0.7 -7.33 -0.41 2.85e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs854765 0.552 rs6502624 chr17:17847936 G/A cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC cis rs116095464 0.558 rs10475136 chr5:232796 A/G cg10591111 chr5:226296 SDHA -0.53 -6.37 -0.36 8.13e-10 Breast cancer; CESC cis rs748404 0.697 rs492743 chr15:43560945 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.8 0.43 1.47e-13 Lung cancer; CESC cis rs2204008 0.528 rs11503820 chr12:38395379 G/A cg26384229 chr12:38710491 ALG10B -0.46 -6.04 -0.35 5.17e-9 Bladder cancer; CESC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg17971929 chr21:40555470 PSMG1 1.07 16.32 0.71 6.47e-42 Cognitive function; CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg07167872 chr1:205819463 PM20D1 0.85 15.13 0.68 1.07e-37 Menarche (age at onset); CESC cis rs909002 0.789 rs2139539 chr1:32117779 C/T cg13919466 chr1:32135498 COL16A1 -0.47 -8.51 -0.46 1.27e-15 Intelligence (multi-trait analysis); CESC cis rs12472274 0.646 rs11688732 chr2:239096622 G/T cg17459225 chr2:239074497 NA 0.51 6.02 0.35 5.77e-9 Phospholipid levels (plasma); CESC cis rs76878669 0.561 rs7115577 chr11:66172258 G/T cg18002602 chr11:66138449 SLC29A2 -0.36 -5.86 -0.34 1.38e-8 Educational attainment (years of education); CESC cis rs12477438 0.798 rs6716913 chr2:99580641 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.51 -0.54 7.92e-22 Chronic sinus infection; CESC cis rs2070488 0.775 rs6794397 chr3:38559307 A/G cg24069376 chr3:38537580 EXOG 0.32 5.43 0.32 1.26e-7 Electrocardiographic conduction measures; CESC cis rs3808502 0.585 rs4549730 chr8:11239078 T/G cg21775007 chr8:11205619 TDH -0.52 -7.89 -0.44 7.81e-14 Neuroticism; CESC cis rs11098499 0.955 rs35916640 chr4:120155852 T/C cg24375607 chr4:120327624 NA 0.42 5.05 0.3 8.26e-7 Corneal astigmatism; CESC cis rs7089973 0.872 rs7918388 chr10:116614563 T/C cg25233709 chr10:116636983 FAM160B1 0.35 5.08 0.3 7.02e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs74181299 0.684 rs60136636 chr2:65338422 G/A cg05010058 chr2:65284262 CEP68 -0.32 -5.29 -0.31 2.63e-7 Pulse pressure; CESC cis rs116095464 0.614 rs4371799 chr5:268192 C/A cg22496380 chr5:211416 CCDC127 -0.73 -8.43 -0.46 2.18e-15 Breast cancer; CESC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg17971929 chr21:40555470 PSMG1 1.03 15.24 0.68 4.35e-38 Cognitive function; CESC cis rs9549367 0.713 rs1755690 chr13:113824266 T/C cg18105134 chr13:113819100 PROZ 0.56 7.33 0.41 2.74e-12 Platelet distribution width; CESC cis rs62408225 0.894 rs4707609 chr6:90946479 T/C cg06866423 chr6:90926672 BACH2 0.43 5.31 0.31 2.28e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg10523679 chr1:76189770 ACADM 0.68 7.81 0.43 1.32e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg20135002 chr11:47629003 NA -0.41 -5.11 -0.3 6.14e-7 Subjective well-being; CESC cis rs2576037 0.796 rs2571030 chr18:44573854 G/A cg19077165 chr18:44547161 KATNAL2 0.53 7.49 0.42 1.03e-12 Personality dimensions; CESC cis rs7666738 0.512 rs1648536 chr4:99019881 G/T cg17366294 chr4:99064904 C4orf37 -0.41 -5.33 -0.31 2.14e-7 Colonoscopy-negative controls vs population controls; CESC trans rs561341 0.882 rs111484028 chr17:30287701 G/A cg20587970 chr11:113659929 NA -1.12 -14.24 -0.66 1.49e-34 Hip circumference adjusted for BMI; CESC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg11644478 chr21:40555479 PSMG1 1.02 16.18 0.7 1.98e-41 Cognitive function; CESC cis rs4843747 0.636 rs11864872 chr16:88105966 A/G cg03395651 chr16:88107091 BANP 0.45 5.31 0.31 2.35e-7 Menopause (age at onset); CESC trans rs11098499 0.863 rs1383533 chr4:120434576 G/A cg25214090 chr10:38739885 LOC399744 0.69 9.45 0.5 1.84e-18 Corneal astigmatism; CESC cis rs6011002 1.000 rs3848668 chr20:62293272 A/G cg15212369 chr20:62274085 STMN3 -0.58 -5.04 -0.3 8.58e-7 Dental caries; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12728516 chr1:155197152 GBAP1 0.46 6.66 0.38 1.54e-10 Fibrinogen levels; CESC cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg10556349 chr10:835070 NA 0.75 6.28 0.36 1.34e-9 Eosinophil percentage of granulocytes; CESC cis rs6495122 0.699 rs12905199 chr15:75070196 A/G cg14664628 chr15:75095509 CSK -0.68 -9.39 -0.5 2.81e-18 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs7772486 0.712 rs1292335 chr6:145967877 G/T cg05347473 chr6:146136440 FBXO30 0.41 5.81 0.34 1.83e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs67311347 1.000 rs73080138 chr3:40516417 A/G cg09455208 chr3:40491958 NA 0.48 8.35 0.46 3.77e-15 Renal cell carcinoma; CESC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg27170947 chr2:26402098 FAM59B -0.87 -9.89 -0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs7914558 0.966 rs10786719 chr10:104637992 C/T cg08650961 chr10:104748594 CNNM2 -0.36 -5.64 -0.33 4.39e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs116095464 0.558 rs10056628 chr5:279512 G/A cg22857025 chr5:266934 NA -1.32 -14.23 -0.66 1.56e-34 Breast cancer; CESC cis rs2180341 1.000 rs2326567 chr6:127606160 G/A cg24812749 chr6:127587940 RNF146 1.06 15.35 0.69 1.74e-38 Breast cancer; CESC trans rs3780486 0.505 rs10813958 chr9:33165985 A/G cg20290983 chr6:43655470 MRPS18A 0.72 11.21 0.57 4.09e-24 IgG glycosylation; CESC cis rs2882667 0.858 rs13176497 chr5:138446074 T/C cg04439458 chr5:138467593 SIL1 -0.39 -6.04 -0.35 5.21e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs763121 0.925 rs5757165 chr22:38994577 C/T cg21395723 chr22:39101663 GTPBP1 0.45 5.94 0.34 8.82e-9 Menopause (age at onset); CESC cis rs9790314 0.875 rs462514 chr3:161092809 C/T cg03342759 chr3:160939853 NMD3 -0.41 -5.39 -0.31 1.59e-7 Morning vs. evening chronotype; CESC cis rs7824557 0.524 rs7835318 chr8:10953874 G/A cg21775007 chr8:11205619 TDH -0.38 -5.42 -0.32 1.32e-7 Retinal vascular caliber; CESC cis rs8060686 0.545 rs11043 chr16:68262958 G/A cg26727032 chr16:67993705 SLC12A4 -0.48 -5.62 -0.33 4.92e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs17125944 0.542 rs75723366 chr14:53256882 T/C cg13660082 chr14:53194042 PSMC6 -0.61 -5.51 -0.32 8.66e-8 Alzheimer's disease (late onset); CESC cis rs5753037 0.585 rs249396 chr22:30213972 T/G cg01021169 chr22:30184971 ASCC2 -0.57 -8.57 -0.47 8.55e-16 Type 1 diabetes; CESC cis rs916888 0.821 rs199509 chr17:44858728 G/A cg14517863 chr17:44321492 NA -0.4 -5.16 -0.3 4.82e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs919433 0.963 rs1896854 chr2:198147776 G/T cg03934865 chr2:198174659 NA -0.46 -6.96 -0.39 2.67e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4718428 0.705 rs4718424 chr7:66376095 G/A cg12165864 chr7:66369176 NA -0.67 -7.8 -0.43 1.41e-13 Corneal structure; CESC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.81e-7 Colonoscopy-negative controls vs population controls; CESC trans rs1814175 0.591 rs11040589 chr11:49862449 A/G cg03929089 chr4:120376271 NA -0.9 -14.75 -0.67 2.44e-36 Height; CESC trans rs11039798 0.588 rs10838979 chr11:48626810 T/G cg15704280 chr7:45808275 SEPT13 0.61 6.29 0.36 1.32e-9 Axial length; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26300613 chr20:42839365 C20orf111 -0.48 -7.11 -0.4 1.11e-11 Gambling; CESC cis rs2070488 0.775 rs1132064 chr3:38566519 T/C cg24069376 chr3:38537580 EXOG -0.32 -5.54 -0.32 7.32e-8 Electrocardiographic conduction measures; CESC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg25405998 chr7:65216604 CCT6P1 0.46 5.21 0.3 3.87e-7 Aortic root size; CESC trans rs9325144 0.600 rs2171405 chr12:38741030 G/T cg23762105 chr12:34175262 ALG10 0.48 6.24 0.36 1.68e-9 Morning vs. evening chronotype; CESC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 9.95 0.52 4.95e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4450798 0.593 rs4552329 chr3:13785609 T/C cg23332027 chr3:13681764 NA 0.39 5.3 0.31 2.47e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg11764359 chr7:65958608 NA -0.79 -11.61 -0.58 1.83e-25 Aortic root size; CESC cis rs3806843 1.000 rs10066278 chr5:140156318 A/C cg26395211 chr5:140044315 WDR55 -0.43 -5.32 -0.31 2.18e-7 Depressive symptoms (multi-trait analysis); CESC cis rs11227306 0.934 rs7940691 chr11:65640906 C/T cg00576331 chr11:65640516 EFEMP2 0.43 5.66 0.33 3.95e-8 DNA methylation (variation); CESC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg18876405 chr7:65276391 NA 0.5 6.84 0.39 5.47e-11 Aortic root size; CESC cis rs7165102 1.000 rs11071846 chr15:65792839 C/T cg11441148 chr15:65824328 PTPLAD1 -0.31 -5.23 -0.31 3.38e-7 Mean corpuscular hemoglobin; CESC cis rs959260 0.688 rs9302990 chr17:73359446 T/C cg20590849 chr17:73267439 MIF4GD -0.56 -6.11 -0.35 3.51e-9 Systemic lupus erythematosus; CESC cis rs13631 1.000 rs13631 chr9:140006202 G/A cg14289826 chr9:140003911 NA 0.39 7.28 0.41 3.83e-12 Cerebrospinal fluid biomarker levels; CESC cis rs2243480 1.000 rs78803505 chr7:65382572 A/T cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg23283495 chr1:209979779 IRF6 0.51 7.28 0.41 3.91e-12 Cleft lip with or without cleft palate; CESC cis rs7927771 1.000 rs11039426 chr11:47863119 G/A cg05585544 chr11:47624801 NA -0.49 -7.61 -0.42 4.89e-13 Subjective well-being; CESC cis rs854765 0.964 rs12950562 chr17:17995166 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.41 -5.39 -0.31 1.52e-7 Total body bone mineral density; CESC cis rs7927592 0.701 rs12226585 chr11:68257861 A/T cg01657329 chr11:68192670 LRP5 0.47 6.35 0.36 9.16e-10 Total body bone mineral density; CESC cis rs6831352 0.918 rs13127153 chr4:100058121 C/T cg12011299 chr4:100065546 ADH4 -0.59 -6.49 -0.37 4.3e-10 Alcohol dependence; CESC cis rs7216064 1.000 rs7209675 chr17:65831258 A/T cg07042672 chr17:66097459 LOC651250 -0.54 -6.35 -0.36 9.38e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs478304 0.651 rs11604462 chr11:65551648 G/A cg10518572 chr11:65560635 OVOL1 -0.3 -5.71 -0.33 2.98e-8 Acne (severe); CESC cis rs2952156 1.000 rs2088126 chr17:37879030 A/G cg00129232 chr17:37814104 STARD3 -0.68 -8.59 -0.47 7.68e-16 Asthma; CESC cis rs7937682 0.921 rs34584980 chr11:111441537 G/A cg09085632 chr11:111637200 PPP2R1B 0.9 9.9 0.52 7.36e-20 Primary sclerosing cholangitis; CESC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg07677032 chr17:61819896 STRADA 0.44 5.88 0.34 1.21e-8 Prudent dietary pattern; CESC cis rs7267979 1.000 rs4815417 chr20:25379526 C/T cg08601574 chr20:25228251 PYGB -0.35 -5.07 -0.3 7.52e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2204008 0.837 rs4432085 chr12:38181146 C/T cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs7223966 1.000 rs72848797 chr17:61934664 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 5.85 0.34 1.45e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs977987 0.806 rs35787595 chr16:75466847 G/C cg03315344 chr16:75512273 CHST6 0.42 5.97 0.34 7.63e-9 Dupuytren's disease; CESC cis rs11122272 0.525 rs61835222 chr1:231537917 C/A cg06096015 chr1:231504339 EGLN1 0.4 5.7 0.33 3.21e-8 Hemoglobin concentration; CESC cis rs1707322 1.000 rs11211200 chr1:46288352 A/G cg03146154 chr1:46216737 IPP 0.71 9.84 0.52 1.16e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg21782813 chr7:2030301 MAD1L1 0.51 7.29 0.41 3.48e-12 Bipolar disorder and schizophrenia; CESC cis rs56046484 0.871 rs34978449 chr15:85580148 A/G cg08123816 chr15:85640762 PDE8A -0.49 -6.25 -0.36 1.63e-9 Testicular germ cell tumor; CESC cis rs734999 0.545 rs12730932 chr1:2559589 T/G cg20673091 chr1:2541236 MMEL1 -0.48 -8.03 -0.44 3.11e-14 Ulcerative colitis; CESC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg17372223 chr3:52568218 NT5DC2 -0.44 -6.6 -0.38 2.28e-10 Bipolar disorder; CESC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg05564831 chr3:52568323 NT5DC2 0.47 7.33 0.41 2.81e-12 Electroencephalogram traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02513141 chr8:19614776 NA -0.41 -6.49 -0.37 4.22e-10 Gambling; CESC cis rs854765 0.647 rs6826 chr17:18011140 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.3 0.36 1.21e-9 Total body bone mineral density; CESC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg04414720 chr1:150670196 GOLPH3L 0.62 9.0 0.48 4.44e-17 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14020326 chr14:105821532 PACS2 -0.55 -6.28 -0.36 1.38e-9 Gut microbiome composition (summer); CESC cis rs7617773 0.539 rs13094496 chr3:48387050 G/C cg11946769 chr3:48343235 NME6 0.64 8.1 0.45 2.09e-14 Coronary artery disease; CESC cis rs9322193 0.543 rs9371533 chr6:150210681 G/A cg09699651 chr6:150184138 LRP11 0.48 6.46 0.37 4.87e-10 Lung cancer; CESC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs2404602 0.735 rs1607015 chr15:76702429 C/T cg00316803 chr15:76480434 C15orf27 0.37 5.05 0.3 8.33e-7 Blood metabolite levels; CESC cis rs9399401 0.710 rs6900087 chr6:142717303 A/T cg04461802 chr6:142623433 GPR126 0.42 6.04 0.35 5.13e-9 Chronic obstructive pulmonary disease; CESC cis rs6754311 0.773 rs666407 chr2:136640233 A/G cg07169764 chr2:136633963 MCM6 0.69 8.58 0.47 8.32e-16 Mosquito bite size; CESC cis rs6831352 0.918 rs1042365 chr4:100045500 G/T cg13256891 chr4:100009986 ADH5 -0.72 -8.09 -0.45 2.13e-14 Alcohol dependence; CESC cis rs77106637 1.000 rs11600585 chr11:72727840 A/G cg03713592 chr11:72463424 ARAP1 1.12 10.28 0.53 4.3e-21 Type 2 diabetes; CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg15147215 chr3:52552868 STAB1 -0.4 -7.45 -0.42 1.35e-12 Electroencephalogram traits; CESC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg14196790 chr5:131705035 SLC22A5 0.32 5.15 0.3 5.04e-7 Breast cancer; CESC cis rs3126085 0.935 rs3126056 chr1:152266503 G/A cg03465714 chr1:152285911 FLG 0.47 5.86 0.34 1.34e-8 Atopic dermatitis; CESC cis rs12142240 0.660 rs7520497 chr1:46824919 C/A cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs992157 0.560 rs4674275 chr2:219097738 G/A cg00012203 chr2:219082015 ARPC2 -0.74 -9.9 -0.52 7.06e-20 Colorectal cancer; CESC cis rs3091242 0.866 rs11249249 chr1:25758134 A/G cg03538708 chr1:25844672 NA -0.43 -6.5 -0.37 3.97e-10 Erythrocyte sedimentation rate; CESC cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6580649 0.883 rs879242 chr12:48503301 T/C cg05342945 chr12:48394962 COL2A1 0.55 6.32 0.36 1.13e-9 Lung cancer; CESC cis rs12477438 0.501 rs12995473 chr2:99764884 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.91 15.68 0.69 1.18e-39 Chronic sinus infection; CESC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg02951883 chr7:2050386 MAD1L1 -0.51 -6.63 -0.38 1.88e-10 Bipolar disorder and schizophrenia; CESC cis rs7267979 0.966 rs454723 chr20:25438928 G/C cg08601574 chr20:25228251 PYGB 0.37 5.27 0.31 2.82e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg18876405 chr7:65276391 NA 0.47 6.26 0.36 1.53e-9 Aortic root size; CESC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg11247378 chr22:39784982 NA -0.66 -9.78 -0.51 1.76e-19 Intelligence (multi-trait analysis); CESC trans rs6089829 0.962 rs4809456 chr20:61660849 C/A cg23505145 chr19:12996616 KLF1 0.52 6.71 0.38 1.21e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs7789940 0.904 rs12531348 chr7:75937191 G/C cg10167463 chr7:75959203 YWHAG -0.51 -6.04 -0.35 5.31e-9 Multiple sclerosis; CESC cis rs7618501 1.000 rs7648987 chr3:49868455 A/G cg24308560 chr3:49941425 MST1R -0.5 -6.75 -0.38 9.41e-11 Intelligence (multi-trait analysis); CESC cis rs35160687 0.509 rs13024436 chr2:86534521 G/A cg01119172 chr2:86362222 SNORD94;PTCD3 -0.43 -5.71 -0.33 3.02e-8 Night sleep phenotypes; CESC cis rs4523957 0.819 rs12450354 chr17:2159982 C/T cg16513277 chr17:2031491 SMG6 0.6 8.18 0.45 1.22e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg24250549 chr1:154909240 PMVK 0.74 11.08 0.56 1.06e-23 Prostate cancer; CESC cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.66 6.4 0.37 7.05e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4253772 0.637 rs8139035 chr22:46651367 A/G cg09491104 chr22:46646882 C22orf40 -0.59 -9.15 -0.49 1.58e-17 LDL cholesterol;Cholesterol, total; CESC cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg01181863 chr3:195395398 SDHAP2 -0.48 -5.71 -0.33 3.03e-8 Pancreatic cancer; CESC cis rs7635838 0.819 rs6776159 chr3:11519324 A/G cg00170343 chr3:11313890 ATG7 0.43 5.8 0.34 1.93e-8 HDL cholesterol; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14065121 chr9:77643271 C9orf41 0.5 7.04 0.4 1.63e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3540 0.554 rs4244879 chr15:91066915 C/T cg10434728 chr15:90938212 IQGAP1 -0.4 -7.02 -0.4 1.85e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs6831352 0.589 rs2924584 chr4:99988208 A/G cg13256891 chr4:100009986 ADH5 0.69 9.66 0.51 4.06e-19 Alcohol dependence; CESC cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg23711669 chr6:146136114 FBXO30 -0.96 -14.96 -0.68 4.17e-37 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26291698 chr6:43445274 TJAP1 -0.46 -6.16 -0.35 2.75e-9 Fibrinogen levels; CESC cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.68 -8.25 -0.45 7.29e-15 Multiple sclerosis; CESC cis rs1018836 0.923 rs9643298 chr8:91552502 G/A cg16814680 chr8:91681699 NA -0.71 -10.3 -0.53 3.78e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4808199 0.947 rs7250658 chr19:19571100 A/G cg03709012 chr19:19516395 GATAD2A 1.17 13.3 0.63 2.85e-31 Nonalcoholic fatty liver disease; CESC cis rs2050392 0.590 rs685319 chr10:30719331 G/A cg02070205 chr10:30722105 MAP3K8 -0.46 -5.39 -0.31 1.59e-7 Inflammatory bowel disease; CESC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg04369109 chr6:150039330 LATS1 -0.44 -6.07 -0.35 4.43e-9 Lung cancer; CESC cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg03213289 chr20:61660250 NA 0.39 6.16 0.35 2.7e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2797160 1.000 rs1418642 chr6:125999768 G/A cg05901451 chr6:126070800 HEY2 -0.46 -6.7 -0.38 1.28e-10 Endometrial cancer; CESC cis rs4722166 0.630 rs4722169 chr7:22785419 C/T cg26061582 chr7:22766209 IL6 0.5 5.48 0.32 9.97e-8 Lung cancer; CESC cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg05340658 chr4:99064831 C4orf37 0.77 11.6 0.58 2.01e-25 Colonoscopy-negative controls vs population controls; CESC cis rs8078723 1.000 rs3826331 chr17:38150492 T/C cg17467752 chr17:38218738 THRA -0.65 -9.52 -0.5 1.13e-18 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs7666738 0.830 rs35276471 chr4:99068691 A/T cg03467027 chr4:99064603 C4orf37 0.48 5.96 0.34 7.81e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9302635 0.513 rs7184169 chr16:72152933 C/T cg01557791 chr16:72042693 DHODH -0.59 -6.84 -0.39 5.42e-11 Blood protein levels; CESC cis rs35110281 0.627 rs7282704 chr21:44966253 A/G cg21573476 chr21:45109991 RRP1B -0.37 -5.04 -0.3 8.67e-7 Mean corpuscular volume; CESC cis rs3733585 0.699 rs28610447 chr4:9971517 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.52 -0.32 8.08e-8 Cleft plate (environmental tobacco smoke interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03424826 chr18:59561551 RNF152 0.56 7.17 0.4 7.25e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg06873352 chr17:61820015 STRADA 0.72 12.91 0.62 6.74e-30 Prudent dietary pattern; CESC cis rs2742234 0.541 rs7096500 chr10:43712095 C/T cg07801480 chr10:43725741 RASGEF1A -0.4 -5.25 -0.31 3.2e-7 Hirschsprung disease; CESC cis rs9837602 1.000 rs1688771 chr3:99503359 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.52 -7.18 -0.4 6.88e-12 Breast cancer; CESC cis rs10883723 0.847 rs3808934 chr10:104264280 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs763014 0.931 rs11643039 chr16:634260 G/A cg07343612 chr16:622815 PIGQ -0.55 -8.03 -0.44 3.16e-14 Height; CESC cis rs992157 1.000 rs2168704 chr2:219142492 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.76 10.57 0.54 5.27e-22 Colorectal cancer; CESC cis rs9467711 0.559 rs12176129 chr6:26514940 C/T cg12826209 chr6:26865740 GUSBL1 0.58 5.09 0.3 6.93e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7312933 0.645 rs12049942 chr12:42587052 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.37 0.36 8.18e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs11249608 0.548 rs6867208 chr5:178455575 G/A cg21905437 chr5:178450457 ZNF879 0.6 8.74 0.47 2.75e-16 Pubertal anthropometrics; CESC cis rs77956314 0.515 rs10850741 chr12:117432004 A/G cg16111737 chr12:117408163 FBXW8 -0.49 -6.13 -0.35 3.22e-9 Subcortical brain region volumes;Hippocampal volume; CESC cis rs9325144 0.671 rs7306605 chr12:38730471 C/T cg26384229 chr12:38710491 ALG10B 0.55 7.82 0.43 1.26e-13 Morning vs. evening chronotype; CESC trans rs8073060 0.586 rs4796098 chr17:33913436 T/C cg19694781 chr19:47549865 TMEM160 0.73 7.01 0.4 1.96e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25485084 chr12:118809325 TAOK3 0.41 6.38 0.36 7.96e-10 Systemic lupus erythematosus; CESC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg10596483 chr8:143751796 JRK -0.43 -5.26 -0.31 3.05e-7 Urinary tract infection frequency; CESC cis rs9457247 0.534 rs9366078 chr6:167399512 A/G cg25258033 chr6:167368657 RNASET2 -0.38 -5.54 -0.32 7.36e-8 Crohn's disease; CESC cis rs734999 0.545 rs6666430 chr1:2698950 G/A cg20673091 chr1:2541236 MMEL1 0.48 7.77 0.43 1.73e-13 Ulcerative colitis; CESC cis rs992157 0.710 rs12612347 chr2:219057338 C/T cg00012203 chr2:219082015 ARPC2 -0.83 -12.17 -0.6 2.28e-27 Colorectal cancer; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg16075951 chr14:24899050 CBLN3;KHNYN -0.46 -6.1 -0.35 3.84e-9 Recombination measurement; CESC cis rs7084402 0.967 rs1649042 chr10:60328663 T/C cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs11048434 0.736 rs1476911 chr12:9090859 C/T cg23795048 chr12:9217529 LOC144571 0.36 5.75 0.33 2.46e-8 Sjögren's syndrome; CESC cis rs7560272 0.723 rs7609249 chr2:73813820 G/A cg20560298 chr2:73613845 ALMS1 -0.51 -7.26 -0.41 4.35e-12 Schizophrenia; CESC cis rs7762018 0.769 rs74838157 chr6:170077323 G/A cg19338460 chr6:170058176 WDR27 -0.76 -7.24 -0.41 4.97e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg18402987 chr7:1209562 NA 0.75 7.52 0.42 8.71e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7208859 0.623 rs170051 chr17:28914153 G/A cg13385521 chr17:29058706 SUZ12P 0.75 5.52 0.32 7.98e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg05872129 chr22:39784769 NA -0.81 -10.84 -0.55 6.6e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg05340658 chr4:99064831 C4orf37 0.65 8.54 0.46 1.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg18876405 chr7:65276391 NA -0.54 -7.06 -0.4 1.46e-11 Aortic root size; CESC cis rs861020 0.630 rs656566 chr1:210006603 C/T cg05527609 chr1:210001259 C1orf107 0.74 9.67 0.51 3.97e-19 Orofacial clefts; CESC cis rs2463822 1.000 rs2246920 chr11:62104937 T/G cg06239285 chr11:62104954 ASRGL1 0.85 8.6 0.47 7.06e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2797160 1.000 rs6910933 chr6:126017155 C/G cg05901451 chr6:126070800 HEY2 0.46 6.52 0.37 3.52e-10 Endometrial cancer; CESC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.39 -0.37 7.41e-10 Depression; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17495092 chr1:39456765 AKIRIN1 -0.48 -6.08 -0.35 4.1e-9 Ulcerative colitis; CESC cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.84 11.38 0.57 1.04e-24 Multiple sclerosis; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10548669 chr15:37782940 NA -0.43 -6.07 -0.35 4.46e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4835473 0.864 rs12507633 chr4:144883883 A/T cg25736465 chr4:144833511 NA 0.39 5.75 0.33 2.4e-8 Immature fraction of reticulocytes; CESC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg05368731 chr17:41323189 NBR1 0.79 10.84 0.55 6.44e-23 Menopause (age at onset); CESC cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg18527119 chr7:66119851 NA -0.47 -5.21 -0.31 3.71e-7 Aortic root size; CESC trans rs1814175 0.616 rs10839388 chr11:49842603 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -6.24 -0.36 1.75e-9 Height; CESC cis rs7267979 1.000 rs2387880 chr20:25377787 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.4e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs1707322 1.000 rs11211223 chr1:46380605 C/T cg05343316 chr1:45956843 TESK2 0.44 5.41 0.32 1.41e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2073300 0.609 rs56094936 chr20:23401586 G/A cg12062639 chr20:23401060 NAPB 1.07 8.16 0.45 1.39e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg04926556 chr7:48128294 UPP1 -0.51 -6.05 -0.35 4.87e-9 Gut microbiota (bacterial taxa); CESC cis rs2066819 1.000 rs11575232 chr12:56744422 G/A cg26714650 chr12:56694279 CS -1.39 -9.17 -0.49 1.37e-17 Psoriasis vulgaris; CESC cis rs3008870 0.585 rs2815382 chr1:67515228 G/A cg02640540 chr1:67518911 SLC35D1 0.66 8.72 0.47 3.05e-16 Lymphocyte percentage of white cells; CESC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg27535305 chr1:53392650 SCP2 -0.33 -5.48 -0.32 1.01e-7 Monocyte count; CESC cis rs2625529 0.526 rs7183810 chr15:72560458 A/T cg16672083 chr15:72433130 SENP8 0.4 5.97 0.34 7.7e-9 Red blood cell count; CESC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg05863683 chr7:1912471 MAD1L1 0.4 5.7 0.33 3.12e-8 Bipolar disorder and schizophrenia; CESC cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs9929218 0.906 rs9933844 chr16:68747001 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -9.6 -0.51 6.29e-19 Colorectal cancer; CESC cis rs9943753 0.525 rs6606708 chr12:109833146 T/C cg19025524 chr12:109796872 NA -0.47 -6.66 -0.38 1.61e-10 HDL cholesterol; CESC trans rs9929218 0.551 rs3785134 chr16:68728938 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.88 14.56 0.67 1.14e-35 Colorectal cancer; CESC cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg20503657 chr10:835505 NA 0.69 6.31 0.36 1.19e-9 Eosinophil percentage of granulocytes; CESC cis rs4253772 0.591 rs6008545 chr22:46686375 C/T cg10541313 chr22:46663664 TTC38 0.55 5.16 0.3 4.96e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4523957 0.583 rs2760744 chr17:2017029 T/C cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs62244186 0.545 rs9284880 chr3:44759389 C/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.48 6.3 0.36 1.22e-9 Depressive symptoms; CESC cis rs155076 0.711 rs4770129 chr13:21882059 T/G cg11317459 chr13:21872234 NA 1.2 15.33 0.69 2.11e-38 White matter hyperintensity burden; CESC cis rs7267979 0.966 rs2261785 chr20:25262403 C/T cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.17e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg05283184 chr6:79620031 NA -0.42 -6.52 -0.37 3.58e-10 Intelligence (multi-trait analysis); CESC cis rs57083693 0.518 rs4764646 chr12:101737886 T/C cg22051763 chr12:101673672 UTP20 -0.45 -5.67 -0.33 3.81e-8 Alcohol dependence (age at onset); CESC cis rs11122272 0.735 rs2572249 chr1:231514829 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -7.28 -0.41 3.86e-12 Hemoglobin concentration; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg10433104 chr11:18417767 LDHA -0.45 -6.1 -0.35 3.75e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs877282 0.583 rs11253429 chr10:823234 A/C cg22713356 chr15:30763199 NA 1.03 9.37 0.5 3.32e-18 Uric acid levels; CESC cis rs9611519 0.639 rs7289989 chr22:41476799 A/C cg03806693 chr22:41940476 POLR3H -0.44 -5.24 -0.31 3.27e-7 Neuroticism; CESC cis rs11098499 0.909 rs35165976 chr4:120325630 G/A cg09307838 chr4:120376055 NA 0.94 13.7 0.64 1.18e-32 Corneal astigmatism; CESC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg18016565 chr1:150552671 MCL1 -0.34 -5.11 -0.3 6.11e-7 Melanoma; CESC cis rs796364 1.000 rs281760 chr2:200787804 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.86 8.24 0.45 8e-15 Schizophrenia; CESC cis rs2439831 0.681 rs478104 chr15:43594900 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.93 11.1 0.56 8.93e-24 Lung cancer in ever smokers; CESC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg21724239 chr8:58056113 NA 0.6 5.45 0.32 1.17e-7 Developmental language disorder (linguistic errors); CESC cis rs6540556 0.723 rs3765240 chr1:209918151 G/A cg05527609 chr1:210001259 C1orf107 -0.48 -5.98 -0.34 7.38e-9 Red blood cell count; CESC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg18876405 chr7:65276391 NA -0.51 -7.13 -0.4 9.62e-12 Aortic root size; CESC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3749237 0.595 rs6797765 chr3:49423976 A/G cg03060546 chr3:49711283 APEH 0.75 11.32 0.57 1.68e-24 Resting heart rate; CESC cis rs2718058 0.613 rs2597272 chr7:37759710 C/G cg15028436 chr7:37888078 TXNDC3 -0.42 -5.98 -0.34 7.08e-9 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11328403 chr17:16120890 PIGL 0.59 6.9 0.39 3.83e-11 Gut microbiome composition (summer); CESC cis rs7412746 0.611 rs3768018 chr1:150723747 T/C cg22823121 chr1:150693482 HORMAD1 0.46 6.26 0.36 1.56e-9 Melanoma; CESC cis rs2425143 0.908 rs6088889 chr20:34175417 C/A cg04508476 chr20:34239394 CPNE1;RBM12 0.52 5.33 0.31 2.11e-7 Blood protein levels; CESC cis rs2354432 0.607 rs4950310 chr1:146659964 A/G cg25205988 chr1:146714368 CHD1L 1.34 9.5 0.5 1.29e-18 Mitochondrial DNA levels; CESC cis rs1568889 0.938 rs12795971 chr11:28355104 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 9.64 0.51 4.7e-19 Bipolar disorder; CESC cis rs2235642 0.893 rs2076442 chr16:1591112 G/T cg07639376 chr16:1584516 IFT140;TMEM204 -0.36 -5.88 -0.34 1.25e-8 Coronary artery disease; CESC cis rs2066819 1.000 rs76151170 chr12:56659320 C/T cg26714650 chr12:56694279 CS -1.43 -10.45 -0.54 1.24e-21 Psoriasis vulgaris; CESC cis rs6500395 1.000 rs904818 chr16:48622582 T/C cg04672837 chr16:48644449 N4BP1 0.52 6.51 0.37 3.83e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1348850 0.914 rs4893957 chr2:178380409 A/G cg22681709 chr2:178499509 PDE11A -0.41 -5.82 -0.34 1.66e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg18099408 chr3:52552593 STAB1 -0.33 -5.45 -0.32 1.17e-7 Bipolar disorder; CESC cis rs7937682 0.855 rs539693 chr11:111477387 A/G cg09085632 chr11:111637200 PPP2R1B -0.95 -14.73 -0.67 2.71e-36 Primary sclerosing cholangitis; CESC cis rs11785693 0.862 rs11778306 chr8:4988269 A/C cg26367366 chr8:4980734 NA 0.67 6.51 0.37 3.78e-10 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg02564969 chr6:151773285 C6orf211;RMND1 0.61 8.41 0.46 2.51e-15 Menarche (age at onset); CESC cis rs6691722 0.543 rs12034846 chr1:24699589 G/A cg18323236 chr1:24743029 NIPAL3 0.36 5.32 0.31 2.2e-7 Response to interferon beta in multiple sclerosis; CESC cis rs12995849 0.905 rs6712210 chr2:106449251 G/A cg16077055 chr2:106428750 NCK2 0.39 6.18 0.35 2.45e-9 Addiction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20963020 chr17:77081760 ENGASE -0.52 -6.45 -0.37 5.23e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22975723 chr15:93258103 NA 0.59 6.19 0.36 2.31e-9 Gut microbiome composition (summer); CESC cis rs12478296 1.000 rs73007129 chr2:243000555 T/C cg06360820 chr2:242988706 NA -0.99 -10.05 -0.53 2.35e-20 Obesity-related traits; CESC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg08888203 chr3:10149979 C3orf24 0.48 6.0 0.35 6.52e-9 Alzheimer's disease; CESC cis rs6828523 0.640 rs74589934 chr4:175868757 G/A cg14561282 chr4:175839468 ADAM29 0.46 5.26 0.31 2.92e-7 Breast cancer; CESC cis rs7212590 0.748 rs8073489 chr17:57861794 A/C cg20303301 chr17:57937339 TUBD1 -0.57 -5.36 -0.31 1.81e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs9682041 1.000 rs6444920 chr3:170090374 A/G cg11886554 chr3:170076028 SKIL 1.05 8.52 0.46 1.25e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs6062302 0.522 rs6089929 chr20:62219679 C/T cg09650180 chr20:62225654 GMEB2 -0.79 -8.81 -0.48 1.7e-16 Glioblastoma; CESC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg24829409 chr8:58192753 C8orf71 -0.69 -7.68 -0.43 3.13e-13 Developmental language disorder (linguistic errors); CESC cis rs757110 0.740 rs10832776 chr11:17385224 C/A cg15432903 chr11:17409602 KCNJ11 0.58 8.15 0.45 1.44e-14 Type 2 diabetes; CESC cis rs4253772 0.530 rs79354880 chr22:46746419 C/A cg24881330 chr22:46731750 TRMU 0.79 5.6 0.33 5.34e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg22823121 chr1:150693482 HORMAD1 0.49 7.42 0.41 1.56e-12 Tonsillectomy; CESC cis rs9300255 0.722 rs12298826 chr12:123829028 A/G cg19016782 chr12:123741754 C12orf65 0.44 6.2 0.36 2.22e-9 Neutrophil percentage of white cells; CESC cis rs6963495 0.818 rs73190163 chr7:105157294 G/T cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs909002 0.962 rs1474181 chr1:32136610 C/G cg13919466 chr1:32135498 COL16A1 -0.52 -9.89 -0.52 7.57e-20 Intelligence (multi-trait analysis); CESC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg26343298 chr8:95960752 TP53INP1 0.36 5.96 0.34 7.8e-9 Type 2 diabetes; CESC cis rs1538970 0.851 rs2055145 chr1:45926495 C/G cg03146154 chr1:46216737 IPP 0.47 5.43 0.32 1.29e-7 Platelet count; CESC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.5 -6.73 -0.38 1.02e-10 Bipolar disorder; CESC trans rs62103177 0.714 rs12607447 chr18:77605212 A/G cg05926928 chr17:57297772 GDPD1 0.75 7.99 0.44 4.26e-14 Opioid sensitivity; CESC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.89 -13.82 -0.65 4.34e-33 Prudent dietary pattern; CESC cis rs7107174 1.000 rs4245459 chr11:78065959 T/G cg02023728 chr11:77925099 USP35 0.48 6.28 0.36 1.37e-9 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26662261 chr17:71228709 C17orf80;FAM104A 0.64 7.68 0.43 3.04e-13 Gut microbiome composition (summer); CESC cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg05347473 chr6:146136440 FBXO30 0.71 8.91 0.48 8.14e-17 Lobe attachment (rater-scored or self-reported); CESC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg22968622 chr17:43663579 NA -0.75 -10.19 -0.53 8.41e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3857536 0.813 rs6455090 chr6:66948909 G/A cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs2276314 0.802 rs4799838 chr18:33597530 T/C cg05985134 chr18:33552581 C18orf21 0.61 7.12 0.4 1.01e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.49 -5.81 -0.34 1.8e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6121246 0.559 rs6060716 chr20:30274847 C/G cg13852791 chr20:30311386 BCL2L1 0.78 10.0 0.52 3.44e-20 Mean corpuscular hemoglobin; CESC cis rs11969893 0.737 rs1358758 chr6:101411891 T/C cg12253828 chr6:101329408 ASCC3 0.72 5.95 0.34 8.27e-9 Economic and political preferences (immigration/crime); CESC cis rs7829975 0.714 rs7823757 chr8:8670177 T/A cg06636001 chr8:8085503 FLJ10661 0.42 5.5 0.32 9.04e-8 Mood instability; CESC cis rs1874326 0.524 rs6467772 chr7:138113643 A/G cg18008034 chr7:138118925 NA -0.41 -5.22 -0.31 3.67e-7 Quantitative traits; CESC cis rs9487051 0.735 rs380774 chr6:109519623 C/T cg01475377 chr6:109611718 NA -0.37 -5.44 -0.32 1.23e-7 Reticulocyte fraction of red cells; CESC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg06028808 chr11:68637592 NA 0.48 5.71 0.33 3.08e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10905065 0.895 rs1858447 chr10:5852230 A/G cg11519256 chr10:5708881 ASB13 -0.4 -5.22 -0.31 3.61e-7 Menopause (age at onset); CESC cis rs854765 0.583 rs8078583 chr17:17811465 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.53 7.31 0.41 3.21e-12 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09777416 chr17:7225013 NEURL4 -0.6 -6.77 -0.38 8.42e-11 Gut microbiome composition (summer); CESC cis rs7845219 0.544 rs4570121 chr8:95917088 C/T cg16049864 chr8:95962084 TP53INP1 -0.49 -7.22 -0.41 5.61e-12 Type 2 diabetes; CESC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10754697 chr17:1504809 SLC43A2 -0.55 -7.26 -0.41 4.34e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1538970 1.000 rs4520450 chr1:45834773 A/G cg05343316 chr1:45956843 TESK2 0.82 11.11 0.56 8.85e-24 Platelet count; CESC cis rs703842 1.000 rs10747783 chr12:58176614 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.73 9.5 0.5 1.32e-18 Multiple sclerosis; CESC cis rs10861342 1.000 rs10861354 chr12:105524294 T/C cg23923672 chr12:105501055 KIAA1033 0.64 5.41 0.32 1.39e-7 IgG glycosylation; CESC cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg17366294 chr4:99064904 C4orf37 0.56 7.52 0.42 8.37e-13 Colonoscopy-negative controls vs population controls; CESC cis rs11240074 0.570 rs7535821 chr1:146953450 G/A cg25205988 chr1:146714368 CHD1L -0.62 -5.03 -0.3 9.05e-7 Type 2 diabetes; CESC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.08e-9 Aortic root size; CESC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg10691866 chr7:65817282 TPST1 0.31 5.17 0.3 4.57e-7 Aortic root size; CESC cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.34 0.46 4.23e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6963495 0.745 rs73192152 chr7:105212258 A/C cg19920283 chr7:105172520 RINT1 0.7 6.36 0.36 8.94e-10 Bipolar disorder (body mass index interaction); CESC cis rs6028335 0.502 rs6028235 chr20:37608550 A/G cg27552599 chr20:37590471 DHX35 0.39 5.81 0.34 1.81e-8 Alcohol and nicotine co-dependence; CESC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg05863683 chr7:1912471 MAD1L1 0.37 5.52 0.32 8.19e-8 Bipolar disorder and schizophrenia; CESC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.85 12.01 0.59 8.38e-27 Age-related macular degeneration (geographic atrophy); CESC cis rs4132509 0.793 rs74379351 chr1:243779604 T/C cg21452805 chr1:244014465 NA 0.61 6.31 0.36 1.18e-9 RR interval (heart rate); CESC trans rs17428076 0.793 rs7584258 chr2:172659836 A/G cg14287618 chr9:37440492 ZBTB5 0.48 6.02 0.35 5.67e-9 Myopia; CESC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.62 0.55 3.47e-22 Platelet count; CESC cis rs9911578 1.000 rs7216680 chr17:56988243 G/C cg12560992 chr17:57184187 TRIM37 0.94 15.36 0.69 1.67e-38 Intelligence (multi-trait analysis); CESC cis rs6121246 0.909 rs6060821 chr20:30294034 C/T cg13852791 chr20:30311386 BCL2L1 0.79 8.23 0.45 8.64e-15 Mean corpuscular hemoglobin; CESC cis rs7255436 0.965 rs7351098 chr19:8451671 G/C cg16745616 chr19:8428856 ANGPTL4 -0.36 -5.49 -0.32 9.22e-8 HDL cholesterol; CESC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg24829409 chr8:58192753 C8orf71 -0.56 -7.01 -0.4 1.97e-11 Developmental language disorder (linguistic errors); CESC cis rs7071206 0.853 rs66786803 chr10:79429941 A/G cg07817648 chr10:79422355 NA -0.8 -10.41 -0.54 1.65e-21 Bone mineral density; CESC cis rs11792861 0.888 rs57314245 chr9:111813832 G/A cg05043794 chr9:111880884 C9orf5 -0.37 -6.31 -0.36 1.2e-9 Menarche (age at onset); CESC cis rs7267979 0.789 rs4815400 chr20:25292560 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -14.56 -0.67 1.07e-35 Liver enzyme levels (alkaline phosphatase); CESC cis rs3749237 0.615 rs55957735 chr3:49438158 G/A cg07636037 chr3:49044803 WDR6 0.62 8.97 0.48 5.41e-17 Resting heart rate; CESC cis rs1670533 1.000 rs13135215 chr4:1054364 A/G cg04106633 chr4:1044584 NA 0.41 5.23 0.31 3.36e-7 Recombination rate (females); CESC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg11663144 chr21:46675770 NA -0.62 -9.76 -0.51 2.06e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg12386194 chr3:101231763 SENP7 -0.4 -5.21 -0.3 3.82e-7 Colorectal cancer; CESC cis rs9611565 0.572 rs139569 chr22:42211141 A/G cg03806693 chr22:41940476 POLR3H -0.74 -8.91 -0.48 8.22e-17 Vitiligo; CESC cis rs2439831 0.571 rs689883 chr15:43812596 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.73 9.44 0.5 1.96e-18 Lung cancer in ever smokers; CESC trans rs7824557 0.564 rs2572392 chr8:11235605 T/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.11 -0.35 3.64e-9 Retinal vascular caliber; CESC trans rs360798 0.512 rs12691187 chr2:62804436 T/A cg07814414 chr15:31774773 NA -0.43 -6.2 -0.36 2.15e-9 Coronary artery disease; CESC cis rs11048434 0.636 rs11614970 chr12:9060053 G/A cg23795048 chr12:9217529 LOC144571 0.34 5.3 0.31 2.45e-7 Sjögren's syndrome; CESC cis rs9303401 0.527 rs7224468 chr17:56749943 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.04 12.96 0.62 4.32e-30 Cognitive test performance; CESC cis rs9912789 0.744 rs9893755 chr17:79187432 C/T cg14413466 chr17:79170920 AZI1 0.46 6.54 0.37 3.07e-10 Frontotemporal dementia; CESC cis rs10751667 0.666 rs7394958 chr11:965944 C/G cg20946044 chr11:1010712 AP2A2 -0.4 -5.46 -0.32 1.12e-7 Alzheimer's disease (late onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11967563 chr10:3186147 PITRM1 0.49 6.79 0.38 7.19e-11 Fibrinogen levels; CESC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.76 0.33 2.3e-8 Menopause (age at onset); CESC cis rs9834373 0.853 rs3923272 chr3:78488245 A/G cg06138941 chr3:78371609 NA -0.42 -5.14 -0.3 5.43e-7 Protein quantitative trait loci; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04592204 chr7:43965870 URGCP;UBE2D4 -0.5 -6.6 -0.38 2.25e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg24607948 chr9:100459097 XPA -0.54 -6.24 -0.36 1.73e-9 Gut microbiota (bacterial taxa); CESC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg21782813 chr7:2030301 MAD1L1 0.48 6.71 0.38 1.17e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1577917 1.000 rs955227 chr6:86651032 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.5 -6.44 -0.37 5.73e-10 Response to antipsychotic treatment; CESC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg22920501 chr2:26401640 FAM59B -0.85 -10.05 -0.53 2.5e-20 Gut microbiome composition (summer); CESC cis rs7520050 0.807 rs6429576 chr1:46216575 T/C cg06784218 chr1:46089804 CCDC17 0.33 5.94 0.34 9.01e-9 Red blood cell count;Reticulocyte count; CESC cis rs9902453 0.817 rs55974138 chr17:28215546 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.12 0.45 1.77e-14 Coffee consumption (cups per day); CESC cis rs708547 0.647 rs1718830 chr4:57888510 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -5.52 -0.32 7.99e-8 Response to bleomycin (chromatid breaks); CESC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg08859206 chr1:53392774 SCP2 -0.65 -9.41 -0.5 2.54e-18 Monocyte count; CESC cis rs6784615 0.744 rs1541495 chr3:52492707 T/C cg12962167 chr3:53033115 SFMBT1 -0.74 -5.05 -0.3 8.32e-7 Waist-hip ratio; CESC cis rs10504229 0.636 rs115738451 chr8:58055133 A/T cg24829409 chr8:58192753 C8orf71 -0.59 -6.7 -0.38 1.22e-10 Developmental language disorder (linguistic errors); CESC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg21784768 chr11:537496 LRRC56 -0.55 -5.11 -0.3 6.14e-7 Body mass index; CESC cis rs7523050 0.643 rs35662800 chr1:109400816 C/A cg08274380 chr1:109419600 GPSM2 0.85 5.61 0.33 5.08e-8 Fat distribution (HIV); CESC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg03351412 chr1:154909251 PMVK 0.68 9.09 0.49 2.32e-17 Prostate cancer; CESC trans rs1545843 0.593 rs4570627 chr12:84796004 A/G cg03015433 chr16:56623111 MT3 -0.34 -6.14 -0.35 3.04e-9 Major depressive disorder; CESC cis rs950776 0.518 rs8025429 chr15:78836362 G/A cg24631222 chr15:78858424 CHRNA5 0.39 5.12 0.3 5.79e-7 Sudden cardiac arrest; CESC cis rs796364 0.806 rs11689664 chr2:201099961 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.77 -6.38 -0.36 7.86e-10 Schizophrenia; CESC cis rs2404602 0.692 rs34287706 chr15:76942402 A/C cg26408565 chr15:76604113 ETFA -0.4 -5.68 -0.33 3.45e-8 Blood metabolite levels; CESC cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.33 0.41 2.71e-12 Tonsillectomy; CESC cis rs2342371 0.848 rs5016648 chr3:196207989 A/G cg15048948 chr3:196158458 UBXN7 -0.42 -5.34 -0.31 1.97e-7 Fat distribution (HIV); CESC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.66 -7.47 -0.42 1.15e-12 Gut microbiome composition (summer); CESC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg00149659 chr3:10157352 C3orf10 0.71 8.45 0.46 2.01e-15 Alzheimer's disease; CESC cis rs8060686 0.641 rs28508024 chr16:68126606 T/C cg26727032 chr16:67993705 SLC12A4 -0.52 -6.3 -0.36 1.24e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg24308560 chr3:49941425 MST1R 0.63 9.56 0.51 8.69e-19 Intelligence (multi-trait analysis); CESC cis rs7772486 0.790 rs6923545 chr6:146244743 A/G cg23711669 chr6:146136114 FBXO30 -0.94 -13.73 -0.64 9.31e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs2180341 0.883 rs6904630 chr6:127696869 A/G cg27446573 chr6:127587934 RNF146 1.05 15.31 0.69 2.37e-38 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03577460 chr14:24836084 NFATC4 -0.46 -6.29 -0.36 1.34e-9 Gut microbiota (bacterial taxa); CESC cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs524281 0.817 rs10791849 chr11:65890597 T/A cg14036092 chr11:66035641 RAB1B -0.61 -6.08 -0.35 4.09e-9 Electroencephalogram traits; CESC cis rs7937682 0.632 rs4936834 chr11:111764017 T/A cg09085632 chr11:111637200 PPP2R1B 0.87 11.02 0.56 1.67e-23 Primary sclerosing cholangitis; CESC cis rs2011503 1.000 rs76790018 chr19:19652157 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC cis rs4930103 0.935 rs4929987 chr11:2028591 C/G cg23202291 chr11:1979235 NA 0.37 5.17 0.3 4.7e-7 DNA methylation (parent-of-origin);DNA methylation (variation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14258078 chr17:62051773 SCN4A -0.44 -7.07 -0.4 1.35e-11 Gut microbiome composition (summer); CESC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg07308232 chr7:1071921 C7orf50 -0.45 -6.03 -0.35 5.41e-9 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24367431 chr1:24828968 RCAN3 0.59 6.09 0.35 3.86e-9 Gut microbiome composition (summer); CESC cis rs8078723 0.802 rs9303283 chr17:38192633 A/G cg17467752 chr17:38218738 THRA 0.67 10.88 0.56 5.07e-23 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs72781680 0.582 rs72783611 chr2:24291445 C/T cg20701182 chr2:24300061 SF3B14 0.93 10.58 0.54 4.83e-22 Lymphocyte counts; CESC cis rs4727963 0.846 rs1357948 chr7:122695727 T/C cg03640110 chr7:122635026 TAS2R16 -0.37 -5.88 -0.34 1.24e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs6733011 0.518 rs12712033 chr2:99457973 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.43 -5.31 -0.31 2.3e-7 Bipolar disorder; CESC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg16145915 chr7:1198662 ZFAND2A -0.5 -7.27 -0.41 3.93e-12 Longevity;Endometriosis; CESC cis rs208520 0.560 rs2351880 chr6:66863707 G/A cg07460842 chr6:66804631 NA -1.02 -13.47 -0.64 7.41e-32 Exhaled nitric oxide output; CESC cis rs1538970 0.748 rs11211137 chr1:46013892 T/A cg24296786 chr1:45957014 TESK2 -0.48 -5.2 -0.3 3.99e-7 Platelet count; CESC cis rs977987 0.586 rs12920883 chr16:75432681 T/C cg03315344 chr16:75512273 CHST6 0.4 5.74 0.33 2.61e-8 Dupuytren's disease; CESC cis rs1215050 0.755 rs811479 chr4:98727398 A/T cg05340658 chr4:99064831 C4orf37 0.51 6.55 0.37 3.04e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1048238 0.846 rs945417 chr1:16344625 C/G cg21214613 chr1:16344536 HSPB7 0.33 5.4 0.31 1.47e-7 Systolic blood pressure; CESC cis rs11792861 0.816 rs28361111 chr9:111761012 A/C cg05043794 chr9:111880884 C9orf5 -0.36 -5.81 -0.34 1.76e-8 Menarche (age at onset); CESC cis rs1707322 1.000 rs11211232 chr1:46411146 C/T cg05343316 chr1:45956843 TESK2 0.49 5.96 0.34 7.82e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01325958 chr17:37793326 STARD3 0.57 6.37 0.36 8.48e-10 Gut microbiome composition (summer); CESC cis rs4566357 0.615 rs10178260 chr2:227914458 G/T cg05526886 chr2:227700861 RHBDD1 -0.45 -5.93 -0.34 9.37e-9 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18224556 chr11:65101075 DPF2 0.57 6.92 0.39 3.47e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22501760 chr22:29137527 CHEK2;HSCB -0.65 -7.63 -0.42 4.18e-13 Gut microbiome composition (summer); CESC cis rs9733 0.744 rs11204725 chr1:150742700 T/C cg13175981 chr1:150552382 MCL1 0.52 7.24 0.41 4.94e-12 Tonsillectomy; CESC cis rs1008375 0.966 rs28750296 chr4:17685826 A/T cg02297831 chr4:17616191 MED28 0.42 5.42 0.32 1.33e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7712401 0.601 rs34126945 chr5:122329729 A/G cg19412675 chr5:122181750 SNX24 -0.41 -5.34 -0.31 2e-7 Mean platelet volume; CESC cis rs113835537 0.935 rs79496339 chr11:66467769 T/A cg22134325 chr11:66188745 NPAS4 0.52 5.94 0.34 8.91e-9 Airway imaging phenotypes; CESC cis rs2276314 0.748 rs4799839 chr18:33597531 T/C cg05985134 chr18:33552581 C18orf21 0.61 7.12 0.4 1.01e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs9815354 0.812 rs60796012 chr3:41908668 T/C cg03022575 chr3:42003672 ULK4 0.7 6.18 0.36 2.38e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7084402 0.967 rs1649043 chr10:60328209 C/T cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs56399783 0.901 rs73049380 chr7:2832845 C/T cg19731401 chr7:2775893 GNA12 0.66 5.95 0.34 8.54e-9 Childhood ear infection; CESC cis rs61935443 0.720 rs11107776 chr12:95294283 T/G cg21533806 chr12:95267307 NA 0.53 6.48 0.37 4.54e-10 Schizophrenia; CESC cis rs7586673 0.930 rs6432667 chr2:161905001 T/C cg22496339 chr2:162101262 NA 0.53 6.78 0.38 7.61e-11 Intelligence (multi-trait analysis); CESC trans rs35110281 0.720 rs162394 chr21:44943550 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.53 -7.17 -0.4 7.59e-12 Mean corpuscular volume; CESC cis rs4332037 0.624 rs11764337 chr7:1892309 A/G cg13880726 chr7:1868755 MAD1L1 0.46 5.04 0.3 8.56e-7 Bipolar disorder; CESC cis rs2797160 0.967 rs2797159 chr6:126009557 G/A cg05901451 chr6:126070800 HEY2 0.45 6.59 0.38 2.39e-10 Endometrial cancer; CESC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg12963246 chr6:28129442 ZNF389 0.5 6.4 0.37 6.93e-10 Parkinson's disease; CESC cis rs734999 0.545 rs6698817 chr1:2564183 T/C cg20673091 chr1:2541236 MMEL1 -0.47 -7.84 -0.43 1.11e-13 Ulcerative colitis; CESC cis rs57506017 0.585 rs5011431 chr7:12268551 G/A cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.64e-7 Neuroticism; CESC cis rs892961 0.836 rs35077273 chr17:75412415 T/C cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg27347728 chr4:17578864 LAP3 0.43 5.12 0.3 5.92e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8114671 0.562 rs6088621 chr20:33418740 C/T cg07148914 chr20:33460835 GGT7 0.42 5.39 0.31 1.52e-7 Height; CESC cis rs1215050 0.755 rs7696354 chr4:98820330 T/C cg05340658 chr4:99064831 C4orf37 0.47 6.06 0.35 4.59e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4450131 0.522 rs3781451 chr10:126355477 G/A cg20435097 chr10:126320824 FAM53B 0.29 5.31 0.31 2.34e-7 White blood cell count (basophil); CESC cis rs926938 0.618 rs360587 chr1:115467553 A/G cg12756093 chr1:115239321 AMPD1 0.51 7.3 0.41 3.31e-12 Autism; CESC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg13393036 chr8:95962371 TP53INP1 -0.48 -10.16 -0.53 1.04e-20 Type 2 diabetes; CESC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg06873352 chr17:61820015 STRADA -0.72 -12.95 -0.62 4.69e-30 Prudent dietary pattern; CESC cis rs9486719 1.000 rs28623445 chr6:96899116 G/T cg18709589 chr6:96969512 KIAA0776 -0.54 -5.87 -0.34 1.3e-8 Migraine;Coronary artery disease; CESC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.51 0.37 3.75e-10 Bipolar disorder; CESC cis rs2439831 0.850 rs3862142 chr15:44064806 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.88 0.44 8.75e-14 Lung cancer in ever smokers; CESC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 10.34 0.54 2.86e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg04944784 chr2:26401820 FAM59B -0.66 -7.49 -0.42 1.03e-12 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg25072359 chr17:41440525 NA 0.43 5.83 0.34 1.61e-8 Menopause (age at onset); CESC cis rs2637266 1.000 rs2395394 chr10:78360679 G/C cg18941641 chr10:78392320 NA 0.42 7.87 0.44 9.23e-14 Pulmonary function; CESC cis rs10411936 1.000 rs1870071 chr19:16505106 A/G cg10248733 chr19:16607483 C19orf44;CALR3 -0.49 -5.91 -0.34 1.04e-8 White blood cell count;Multiple sclerosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16554516 chr1:206680868 RASSF5 -0.44 -6.3 -0.36 1.26e-9 Fibrinogen levels; CESC cis rs9467773 1.000 rs9467779 chr6:26536687 A/T cg26531700 chr6:26746687 NA 0.33 5.12 0.3 5.92e-7 Intelligence (multi-trait analysis); CESC cis rs1665050 0.534 rs11855896 chr15:59234646 G/C cg05156742 chr15:59063176 FAM63B 0.5 6.42 0.37 6.18e-10 Atopic dermatitis; CESC cis rs7223966 0.515 rs2727315 chr17:61961458 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.1 0.4 1.15e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1801251 1.000 rs2012221 chr2:233566848 T/C cg25237894 chr2:233734115 C2orf82 0.5 8.64 0.47 5.54e-16 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11642829 chr17:4607740 PELP1 0.56 6.61 0.38 2.07e-10 Gut microbiome composition (summer); CESC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg00074818 chr8:8560427 CLDN23 0.36 5.17 0.3 4.63e-7 Obesity-related traits; CESC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg18225595 chr11:63971243 STIP1 0.52 5.13 0.3 5.55e-7 Mean platelet volume; CESC cis rs6484504 0.576 rs158139 chr11:31216076 C/T cg14844989 chr11:31128820 NA -0.41 -5.86 -0.34 1.34e-8 Red blood cell count; CESC cis rs748404 0.650 rs518261 chr15:43573429 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.59 7.76 0.43 1.84e-13 Lung cancer; CESC cis rs7267979 0.966 rs4815425 chr20:25398876 G/C cg08601574 chr20:25228251 PYGB -0.38 -5.46 -0.32 1.08e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs11195062 0.521 rs4918485 chr10:111949323 A/T cg00817464 chr10:111662876 XPNPEP1 0.52 7.13 0.4 9.27e-12 Multiple myeloma; CESC cis rs4722166 0.630 rs12700390 chr7:22777129 G/T cg13104385 chr7:22767384 IL6 0.48 6.43 0.37 5.96e-10 Lung cancer; CESC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg06634786 chr22:41940651 POLR3H -0.64 -6.69 -0.38 1.3e-10 Vitiligo; CESC cis rs17270561 0.779 rs1165200 chr6:25875212 C/T cg17691542 chr6:26056736 HIST1H1C -0.69 -8.37 -0.46 3.47e-15 Iron status biomarkers; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11680442 chr3:127309618 TPRA1 -0.47 -6.24 -0.36 1.77e-9 Asthma; CESC cis rs7072216 0.763 rs7914401 chr10:100163928 A/G cg26618903 chr10:100175079 PYROXD2 -0.35 -5.41 -0.32 1.41e-7 Metabolite levels; CESC trans rs35110281 0.805 rs4818843 chr21:45006607 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 7.63 0.42 4.31e-13 Mean corpuscular volume; CESC cis rs7678296 0.649 rs4585313 chr4:37240236 C/T cg06805348 chr4:37245195 KIAA1239 -0.53 -5.59 -0.32 5.73e-8 3-hydroxypropylmercapturic acid levels in smokers; CESC trans rs61931739 0.500 rs3934517 chr12:34451396 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.5 0.42 9.79e-13 Morning vs. evening chronotype; CESC cis rs2730245 0.505 rs1188956 chr7:158690576 G/A cg24397884 chr7:158709396 WDR60 0.81 12.73 0.62 2.72e-29 Height; CESC cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg13877915 chr19:58951672 ZNF132 0.39 5.8 0.34 1.93e-8 Uric acid clearance; CESC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg11764359 chr7:65958608 NA -0.79 -11.55 -0.58 2.79e-25 Aortic root size; CESC cis rs2997447 0.792 rs61775432 chr1:26416376 A/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.66 5.53 0.32 7.83e-8 QRS complex (12-leadsum); CESC cis rs7927592 0.913 rs59056571 chr11:68272973 T/G cg20283391 chr11:68216788 NA -0.62 -7.54 -0.42 7.45e-13 Total body bone mineral density; CESC cis rs1957429 0.808 rs1570296 chr14:65332294 T/A cg23373153 chr14:65346875 NA 0.88 9.2 0.49 1.13e-17 Pediatric areal bone mineral density (radius); CESC cis rs7927771 1.000 rs10838757 chr11:47763016 T/C cg20307385 chr11:47447363 PSMC3 -0.5 -6.13 -0.35 3.18e-9 Subjective well-being; CESC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg16325326 chr1:53192061 ZYG11B 0.93 16.14 0.7 2.85e-41 Monocyte count; CESC cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg11366901 chr6:160182831 ACAT2 0.77 9.47 0.5 1.65e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs72945132 0.882 rs7128969 chr11:70205017 C/A cg14191688 chr11:70257035 CTTN 0.42 5.19 0.3 4.1e-7 Coronary artery disease; CESC cis rs651907 0.557 rs11924013 chr3:101366698 G/A cg12386194 chr3:101231763 SENP7 0.44 5.57 0.32 6.2e-8 Colorectal cancer; CESC cis rs2637266 0.703 rs1099884 chr10:78513301 G/T cg18941641 chr10:78392320 NA 0.38 7.5 0.42 9.82e-13 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21220614 chr22:43266108 NA -0.52 -6.06 -0.35 4.67e-9 Gut microbiome composition (summer); CESC cis rs2075371 0.501 rs1421469 chr7:134028260 C/G cg20476274 chr7:133979776 SLC35B4 0.4 5.17 0.3 4.64e-7 Mean platelet volume; CESC cis rs7107174 1.000 rs10899481 chr11:78058721 A/T cg02023728 chr11:77925099 USP35 -0.38 -5.22 -0.31 3.53e-7 Testicular germ cell tumor; CESC cis rs12477438 0.520 rs13031919 chr2:99848932 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.69 10.2 0.53 8.06e-21 Chronic sinus infection; CESC cis rs734999 0.545 rs4474198 chr1:2553758 C/T cg20673091 chr1:2541236 MMEL1 0.46 8.05 0.44 2.81e-14 Ulcerative colitis; CESC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg04414720 chr1:150670196 GOLPH3L 0.58 7.55 0.42 7.07e-13 Melanoma; CESC cis rs67460515 0.892 rs73026976 chr3:160964271 G/A cg03342759 chr3:160939853 NMD3 -0.55 -7.79 -0.43 1.5e-13 Parkinson's disease; CESC cis rs1018836 0.884 rs9643307 chr8:91625257 A/C cg16814680 chr8:91681699 NA -0.72 -9.98 -0.52 3.92e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs34779708 0.966 rs4934730 chr10:35415555 A/G cg03585969 chr10:35415529 CREM 0.76 10.01 0.52 3.26e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13755614 chr9:131710194 DOLK;NUP188 0.54 6.47 0.37 4.69e-10 Gut microbiome composition (summer); CESC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg21782813 chr7:2030301 MAD1L1 0.37 5.2 0.3 3.9e-7 Bipolar disorder and schizophrenia; CESC cis rs4689388 0.791 rs1046317 chr4:6304242 T/C cg00701064 chr4:6280414 WFS1 0.6 8.85 0.48 1.25e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg25405998 chr7:65216604 CCT6P1 -0.51 -5.53 -0.32 7.66e-8 Aortic root size; CESC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg03188948 chr7:1209495 NA 0.71 6.87 0.39 4.6e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6582630 0.519 rs1851121 chr12:38389467 T/C cg13010199 chr12:38710504 ALG10B 0.49 6.25 0.36 1.67e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg17178900 chr1:205818956 PM20D1 -0.38 -5.09 -0.3 6.94e-7 White blood cell count (basophil);Basophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06192289 chr12:102513805 NUP37;C12orf48 0.52 6.03 0.35 5.6e-9 Gut microbiome composition (summer); CESC cis rs9733 0.687 rs12410050 chr1:150857141 A/G cg18016565 chr1:150552671 MCL1 -0.37 -5.91 -0.34 1.03e-8 Tonsillectomy; CESC cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.66 7.9 0.44 7.34e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg16339924 chr4:17578868 LAP3 0.75 9.36 0.5 3.65e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs796364 0.616 rs2103094 chr2:200687954 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.57 5.23 0.31 3.39e-7 Schizophrenia; CESC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg11764359 chr7:65958608 NA 0.8 9.57 0.51 7.82e-19 Aortic root size; CESC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Parkinson's disease; CESC cis rs7216064 1.000 rs7223813 chr17:65945840 A/G cg12091567 chr17:66097778 LOC651250 -0.7 -7.14 -0.4 9.02e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg00074818 chr8:8560427 CLDN23 0.38 5.46 0.32 1.1e-7 Obesity-related traits; CESC cis rs12410462 0.681 rs75876430 chr1:227661157 A/G cg04117972 chr1:227635322 NA 0.76 6.64 0.38 1.73e-10 Major depressive disorder; CESC cis rs4604732 0.527 rs12031949 chr1:247624463 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.49 0.32 9.6e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs854765 0.647 rs712267 chr17:18021607 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.25 0.36 1.6e-9 Total body bone mineral density; CESC cis rs1062177 1.000 rs2964584 chr5:151142878 T/C cg12924095 chr5:151150029 G3BP1 0.47 6.04 0.35 5.22e-9 Preschool internalizing problems; CESC cis rs12291225 0.535 rs12806025 chr11:14413817 G/A cg19336497 chr11:14380999 RRAS2 -0.35 -5.16 -0.3 4.82e-7 Sense of smell; CESC cis rs1478897 0.804 rs9329246 chr8:11392880 A/G cg09528494 chr8:11338675 NA 0.31 5.72 0.33 2.93e-8 Systemic lupus erythematosus; CESC trans rs11098499 0.909 rs6842762 chr4:120398236 A/T cg25214090 chr10:38739885 LOC399744 0.72 10.31 0.54 3.55e-21 Corneal astigmatism; CESC cis rs2708240 0.577 rs1186173 chr7:147546603 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.49 -0.32 9.48e-8 QT interval (drug interaction); CESC trans rs4335177 0.762 rs4461961 chr9:109321818 C/T cg00697916 chr3:65342644 MAGI1 0.32 6.0 0.35 6.5e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18247339 chr14:35183597 CFL2 -0.47 -6.05 -0.35 4.98e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14536777 chr8:145665811 NFKBIL2 -0.57 -7.04 -0.4 1.67e-11 Gut microbiome composition (summer); CESC trans rs1814175 0.645 rs7395438 chr11:49877379 G/T cg15704280 chr7:45808275 SEPT13 -0.98 -18.2 -0.75 1.48e-48 Height; CESC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg06713675 chr4:122721982 EXOSC9 -0.51 -7.02 -0.4 1.9e-11 Type 2 diabetes; CESC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16424519 chr16:21531031 SLC7A5P2 0.48 6.12 0.35 3.44e-9 Gut microbiota (bacterial taxa); CESC cis rs9640161 0.789 rs34495356 chr7:150057791 A/G cg27494647 chr7:150038898 RARRES2 0.42 5.12 0.3 5.75e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07766779 chr6:149887504 C6orf72 0.53 6.37 0.36 8.53e-10 Gut microbiome composition (summer); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg03532253 chr12:56399235 SUOX 0.42 6.82 0.39 6.09e-11 Thyroid stimulating hormone; CESC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg22823121 chr1:150693482 HORMAD1 -0.49 -7.33 -0.41 2.86e-12 Tonsillectomy; CESC cis rs2839186 0.967 rs4819222 chr21:47707778 G/A cg10351095 chr21:47802916 PCNT -0.51 -6.85 -0.39 5.26e-11 Testicular germ cell tumor; CESC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg17971929 chr21:40555470 PSMG1 1.09 16.94 0.72 3.91e-44 Cognitive function; CESC cis rs4450131 0.522 rs3781453 chr10:126348761 T/C cg20435097 chr10:126320824 FAM53B 0.28 5.15 0.3 5.07e-7 White blood cell count (basophil); CESC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg04317338 chr11:64019027 PLCB3 0.84 8.71 0.47 3.34e-16 Mean platelet volume; CESC cis rs17041941 1.000 rs35718992 chr2:111998256 A/C cg23466623 chr2:111982296 NA 0.48 5.43 0.32 1.3e-7 Cognitive function; CESC cis rs7188697 0.848 rs37062 chr16:58567238 A/G cg02549819 chr16:58548995 SETD6 -0.42 -5.25 -0.31 3.1e-7 QT interval; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17092583 chr11:735575 NA 0.39 6.09 0.35 4.04e-9 Fibrinogen levels; CESC cis rs17125944 0.505 rs2295827 chr14:53174981 C/T cg13660082 chr14:53194042 PSMC6 -0.66 -5.92 -0.34 1.01e-8 Alzheimer's disease (late onset); CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg07823935 chr2:183902842 NCKAP1 0.44 6.14 0.35 3.06e-9 Positive affect; CESC cis rs10927875 0.757 rs4661679 chr1:16321010 C/T cg21385522 chr1:16154831 NA 0.47 5.91 0.34 1.05e-8 Dilated cardiomyopathy; CESC cis rs113835537 0.529 rs79798028 chr11:66199362 T/G cg24851651 chr11:66362959 CCS 0.46 5.99 0.35 6.96e-9 Airway imaging phenotypes; CESC cis rs6570726 0.846 rs6914304 chr6:145921017 T/C cg05347473 chr6:146136440 FBXO30 0.47 6.22 0.36 1.97e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs910316 1.000 rs175442 chr14:75603564 T/C cg08847533 chr14:75593920 NEK9 -0.98 -18.77 -0.76 1.37e-50 Height; CESC cis rs919433 0.926 rs787996 chr2:198216805 A/G cg03934865 chr2:198174659 NA 0.44 6.47 0.37 4.71e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9814567 1.000 rs4974484 chr3:134219019 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.98 -0.35 7.05e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg04944784 chr2:26401820 FAM59B -0.66 -7.57 -0.42 6.39e-13 Gut microbiome composition (summer); CESC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg05896524 chr21:47604654 C21orf56 0.44 5.78 0.33 2.1e-8 Testicular germ cell tumor; CESC cis rs3820928 0.605 rs13410141 chr2:227805529 A/G cg05526886 chr2:227700861 RHBDD1 -0.54 -7.41 -0.41 1.73e-12 Pulmonary function; CESC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg25072359 chr17:41440525 NA 0.43 5.78 0.33 2.04e-8 Menopause (age at onset); CESC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg15147215 chr3:52552868 STAB1 -0.32 -5.33 -0.31 2.1e-7 Electroencephalogram traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22194305 chr4:2264032 MXD4 -0.46 -6.61 -0.38 2.11e-10 Gambling; CESC cis rs2721195 0.626 rs59464125 chr8:145857786 G/A cg26752003 chr8:145688521 CYHR1 0.47 6.43 0.37 6e-10 Age at first birth; CESC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg13012494 chr21:47604986 C21orf56 0.44 5.86 0.34 1.39e-8 Testicular germ cell tumor; CESC cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg23018236 chr17:30244563 NA -0.58 -5.59 -0.32 5.77e-8 Hip circumference adjusted for BMI; CESC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg03676636 chr4:99064102 C4orf37 0.37 5.35 0.31 1.87e-7 Colonoscopy-negative controls vs population controls; CESC cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 6.09 0.35 3.91e-9 Colorectal cancer; CESC cis rs10129255 0.957 rs6576228 chr14:107186640 A/G cg23076370 chr14:107095027 NA -0.49 -6.35 -0.36 9.11e-10 Kawasaki disease; CESC trans rs427691 0.625 rs370575 chr5:109011288 A/G cg00054525 chr16:88717587 CYBA -0.6 -6.47 -0.37 4.7e-10 Autism spectrum disorder or schizophrenia; CESC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg18016565 chr1:150552671 MCL1 0.33 5.16 0.3 4.96e-7 Tonsillectomy; CESC cis rs7264396 0.790 rs6060530 chr20:34227663 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.6 6.51 0.37 3.84e-10 Total cholesterol levels; CESC trans rs11098499 0.739 rs951570 chr4:120150467 T/C cg25214090 chr10:38739885 LOC399744 -0.57 -7.56 -0.42 6.59e-13 Corneal astigmatism; CESC cis rs1348850 0.831 rs1345139 chr2:178449791 G/T cg23306229 chr2:178417860 TTC30B 0.45 5.71 0.33 3.01e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7917772 0.582 rs7091252 chr10:104328859 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.61 0.33 5.05e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg10523679 chr1:76189770 ACADM 0.75 10.07 0.53 2.05e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs12142240 0.698 rs17357628 chr1:46808462 A/G cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs501120 0.636 rs920172 chr10:44782724 T/C cg09554077 chr10:44749378 NA 0.65 5.39 0.31 1.53e-7 Coronary artery disease;Coronary heart disease; CESC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs1707322 1.000 rs11211205 chr1:46321874 C/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4803468 0.967 rs11670583 chr19:41920440 A/T cg14132834 chr19:41945861 ATP5SL -0.67 -8.23 -0.45 8.57e-15 Height; CESC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg15145296 chr3:125709740 NA -0.5 -5.35 -0.31 1.86e-7 Blood pressure (smoking interaction); CESC cis rs7107174 1.000 rs10793300 chr11:78019582 T/A cg02023728 chr11:77925099 USP35 0.48 6.27 0.36 1.46e-9 Testicular germ cell tumor; CESC cis rs9527 0.567 rs11191573 chr10:104896816 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs2070488 0.965 rs7372849 chr3:38524328 G/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.93 16.67 0.72 3.66e-43 Electrocardiographic conduction measures; CESC cis rs9649465 0.561 rs2429620 chr7:123430012 A/G cg03229431 chr7:123269106 ASB15 0.4 5.46 0.32 1.1e-7 Migraine; CESC cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg00701064 chr4:6280414 WFS1 -0.78 -11.23 -0.57 3.33e-24 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs116095464 0.558 rs6555055 chr5:226160 A/C cg22857025 chr5:266934 NA -1.27 -18.8 -0.76 1.13e-50 Breast cancer; CESC cis rs568617 1.000 rs693824 chr11:65654783 A/G cg00576331 chr11:65640516 EFEMP2 -0.45 -5.35 -0.31 1.95e-7 Crohn's disease; CESC trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -8.4 -0.46 2.72e-15 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07719772 chr16:32360419 NA -0.62 -6.69 -0.38 1.32e-10 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23181591 chr8:123793873 ZHX2 -0.44 -6.26 -0.36 1.56e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26526983 chr16:12136938 RUNDC2A -0.59 -7.05 -0.4 1.52e-11 Gut microbiome composition (summer); CESC cis rs6460942 0.908 rs3887296 chr7:12257966 A/G cg20607287 chr7:12443886 VWDE -0.55 -5.69 -0.33 3.34e-8 Coronary artery disease; CESC cis rs10927875 0.541 rs1739840 chr1:16342237 A/G cg22431228 chr1:16359049 CLCNKA -0.52 -9.9 -0.52 7.22e-20 Dilated cardiomyopathy; CESC cis rs727505 0.564 rs67745021 chr7:124868018 T/C cg23710748 chr7:124431027 NA -0.34 -5.19 -0.3 4.19e-7 Lewy body disease; CESC cis rs7098414 0.511 rs10466236 chr10:82149717 C/T cg00277334 chr10:82204260 NA 0.5 7.55 0.42 7.11e-13 Post bronchodilator FEV1; CESC cis rs9894429 0.716 rs7405578 chr17:79588306 C/A cg13777783 chr17:79615861 NA -0.32 -5.09 -0.3 6.76e-7 Eye color traits; CESC cis rs7267979 0.868 rs6138550 chr20:25223430 C/T cg08601574 chr20:25228251 PYGB 0.44 6.36 0.36 8.57e-10 Liver enzyme levels (alkaline phosphatase); CESC cis rs796364 0.715 rs1106399 chr2:201003837 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.64 -6.04 -0.35 5.26e-9 Schizophrenia; CESC cis rs709400 0.633 rs10143247 chr14:103920927 G/A cg12935359 chr14:103987150 CKB -0.51 -7.46 -0.42 1.24e-12 Body mass index; CESC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.68 -7.7 -0.43 2.76e-13 Gut microbiome composition (summer); CESC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.34 0.31 2.05e-7 Cognitive function; CESC cis rs6912958 0.712 rs4706294 chr6:88317675 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.83 -0.39 5.9e-11 Monocyte percentage of white cells; CESC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg13770153 chr20:60521292 NA -0.81 -11.62 -0.58 1.65e-25 Obesity-related traits; CESC cis rs1215050 0.740 rs783932 chr4:98973936 C/G cg17366294 chr4:99064904 C4orf37 -0.38 -5.04 -0.3 8.72e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs8017423 0.647 rs12589952 chr14:90821364 T/C cg14092571 chr14:90743983 NA 0.44 6.66 0.38 1.55e-10 Mortality in heart failure; CESC cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.87 9.04 0.49 3.35e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.61 7.76 0.43 1.82e-13 Tonsillectomy; CESC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg04267008 chr7:1944627 MAD1L1 -0.59 -7.47 -0.42 1.16e-12 Bipolar disorder and schizophrenia; CESC cis rs9815354 0.680 rs73073290 chr3:42027684 T/G cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs4664308 0.967 rs17241792 chr2:160915205 C/T cg03641300 chr2:160917029 PLA2R1 -0.67 -10.13 -0.53 1.34e-20 Idiopathic membranous nephropathy; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg22929808 chr12:58027113 B4GALNT1 0.4 6.04 0.35 5.3300000000000004e-09 Post-traumatic stress disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19734257 chr20:56064117 HMGB1L1 -0.44 -6.73 -0.38 1.04e-10 Gut microbiota (bacterial taxa); CESC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg01017244 chr2:74357527 NA 0.65 9.29 0.5 5.92e-18 Gestational age at birth (maternal effect); CESC trans rs2727020 0.638 rs1164668 chr11:49330627 A/C cg15704280 chr7:45808275 SEPT13 0.89 14.5 0.67 1.84e-35 Coronary artery disease; CESC cis rs7129220 0.588 rs61878631 chr11:10134832 C/T cg01453529 chr11:10209919 SBF2 -0.48 -5.5 -0.32 8.85e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs12638540 0.543 rs12487678 chr3:32603358 A/C cg11605617 chr3:32612461 DYNC1LI1 0.63 5.45 0.32 1.14e-7 Mortality in heart failure; CESC cis rs12586317 0.547 rs74243586 chr14:35477325 C/T cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC cis rs11098499 0.909 rs28581362 chr4:120283548 T/A cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs2066819 1.000 rs2291361 chr12:56717805 G/A cg26714650 chr12:56694279 CS -1.48 -9.9 -0.52 7.03e-20 Psoriasis vulgaris; CESC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg27535305 chr1:53392650 SCP2 -0.32 -5.33 -0.31 2.13e-7 Monocyte count; CESC cis rs9513627 0.512 rs9517759 chr13:100180108 T/G cg25919922 chr13:100150906 NA 0.78 9.02 0.48 3.9e-17 Obesity-related traits; CESC cis rs9926296 0.656 rs2376882 chr16:89827002 T/C cg04287289 chr16:89883240 FANCA 0.57 7.62 0.42 4.55e-13 Vitiligo; CESC cis rs9467773 1.000 rs9467791 chr6:26562486 A/G cg11502198 chr6:26597334 ABT1 -0.41 -5.8 -0.34 1.92e-8 Intelligence (multi-trait analysis); CESC trans rs9906155 0.748 rs11872015 chr17:75669846 G/C cg14889768 chr6:146864529 RAB32 0.86 6.24 0.36 1.77e-9 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16370856 chr5:56470520 GPBP1 0.53 7.21 0.4 5.8e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.921 rs2281332 chr22:41746212 T/C cg06634786 chr22:41940651 POLR3H -0.44 -5.03 -0.3 9.12e-7 Vitiligo; CESC cis rs6430585 0.528 rs78274583 chr2:136734569 C/T cg07169764 chr2:136633963 MCM6 1.28 17.47 0.73 5.26e-46 Corneal structure; CESC cis rs7216064 1.000 rs6504555 chr17:65940727 A/G cg07042672 chr17:66097459 LOC651250 0.63 7.69 0.43 2.97e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1878047 0.665 rs12972888 chr19:51775714 C/G cg14884932 chr19:51774451 NA -0.37 -5.16 -0.3 4.87e-7 Body mass index; CESC cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg17366294 chr4:99064904 C4orf37 0.64 9.1 0.49 2.3e-17 Colonoscopy-negative controls vs population controls; CESC cis rs727563 0.520 rs132773 chr22:42031768 T/A cg06481639 chr22:41940642 POLR3H 0.57 5.97 0.34 7.74e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg03676636 chr4:99064102 C4orf37 0.36 5.37 0.31 1.69e-7 Colonoscopy-negative controls vs population controls; CESC cis rs208520 1.000 rs208520 chr6:66952828 G/T cg07460842 chr6:66804631 NA -0.8 -9.18 -0.49 1.3e-17 Exhaled nitric oxide output; CESC cis rs2243480 1.000 rs316307 chr7:65570171 C/T cg18252515 chr7:66147081 NA -1.37 -13.56 -0.64 3.47e-32 Diabetic kidney disease; CESC cis rs4919087 0.715 rs1253387 chr10:99032968 G/A cg25902810 chr10:99078978 FRAT1 -0.46 -5.15 -0.3 5.08e-7 Monocyte count; CESC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.53 7.12 0.4 1.04e-11 Lymphocyte counts; CESC cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg00166722 chr3:10149974 C3orf24 0.53 6.65 0.38 1.64e-10 Alzheimer's disease; CESC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg21770322 chr7:97807741 LMTK2 0.55 8.27 0.45 6.54e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs6445797 0.662 rs17056878 chr3:56583072 C/T cg13792233 chr3:56591045 CCDC66 0.4 5.2 0.3 4.06e-7 Gastritis; CESC cis rs7772486 0.754 rs702324 chr6:146008793 A/G cg23711669 chr6:146136114 FBXO30 -0.87 -12.3 -0.6 8.07e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs4563143 0.592 rs12151001 chr19:29283386 C/G cg04546413 chr19:29218101 NA 0.52 6.75 0.38 9.46e-11 Methadone dose in opioid dependence; CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg01238044 chr22:24384105 GSTT1 -0.65 -8.76 -0.47 2.33e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1348850 0.914 rs12612857 chr2:178467144 A/G cg23306229 chr2:178417860 TTC30B 0.61 7.79 0.43 1.55e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1949733 0.585 rs2631768 chr4:8473050 A/G cg11789530 chr4:8429930 ACOX3 -0.57 -7.06 -0.4 1.44e-11 Response to antineoplastic agents; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg11184091 chr9:131843633 DOLPP1 0.46 6.49 0.37 4.3e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg14416726 chr6:151773293 C6orf211;RMND1 0.52 6.63 0.38 1.82e-10 Menarche (age at onset); CESC cis rs7786877 0.626 rs11983745 chr7:100223678 T/C cg27028030 chr7:100209634 MOSPD3 0.58 5.51 0.32 8.71e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7762018 0.891 rs1981069 chr6:170148837 G/A cg13891659 chr6:170190454 C6orf122;C6orf208 0.67 6.53 0.37 3.28e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs8031584 1.000 rs35811129 chr15:31241346 G/A cg08704250 chr15:31115839 NA -0.68 -8.45 -0.46 1.92e-15 Huntington's disease progression; CESC cis rs9399135 0.935 rs9376086 chr6:135371329 T/C cg24558204 chr6:135376177 HBS1L 0.51 6.99 0.39 2.27e-11 Red blood cell count; CESC cis rs11785400 0.793 rs4371985 chr8:143737279 C/T cg10596483 chr8:143751796 JRK 0.42 5.17 0.3 4.51e-7 Schizophrenia; CESC cis rs10911251 0.546 rs20560 chr1:183105534 T/C ch.1.3577855R chr1:183094577 LAMC1 0.85 13.19 0.63 6.92e-31 Colorectal cancer; CESC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg05861140 chr6:150128134 PCMT1 -0.34 -5.04 -0.3 8.49e-7 Lung cancer; CESC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg06481639 chr22:41940642 POLR3H 0.6 5.92 0.34 9.88e-9 Vitiligo; CESC cis rs60843830 1.000 rs7595075 chr2:264019 C/A cg00108164 chr2:264199 ACP1;SH3YL1 0.8 10.45 0.54 1.25e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs2637266 0.703 rs846575 chr10:78500483 G/A cg18941641 chr10:78392320 NA 0.38 7.52 0.42 8.55e-13 Pulmonary function; CESC trans rs61931739 0.534 rs2667447 chr12:34133468 C/A cg26384229 chr12:38710491 ALG10B 0.51 6.8 0.39 6.9e-11 Morning vs. evening chronotype; CESC trans rs7246760 0.618 rs73008113 chr19:9738196 C/T cg02900749 chr2:68251473 NA -0.8 -6.18 -0.35 2.43e-9 Pursuit maintenance gain; CESC cis rs10883723 0.518 rs10786679 chr10:104315667 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.45 5.98 0.34 7.21e-9 Allergic disease (asthma, hay fever or eczema); CESC trans rs12599106 0.707 rs2163977 chr16:34916134 A/G cg26668828 chr6:292823 DUSP22 -0.7 -9.05 -0.49 3.09e-17 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07508942 chr7:5267994 WIPI2 0.47 6.22 0.36 1.93e-9 Fibrinogen levels; CESC cis rs55882075 0.750 rs13184690 chr5:179146993 T/C cg14593053 chr5:179126677 CANX 0.6 8.88 0.48 1.05e-16 Monocyte percentage of white cells; CESC trans rs877282 0.842 rs7092986 chr10:756373 G/A cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs1267303 0.682 rs1886117 chr1:46964909 T/A cg25110126 chr1:46999211 NA -0.54 -6.23 -0.36 1.78e-9 Monobrow; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00975115 chr16:30958403 FBXL19 0.48 6.03 0.35 5.37e-9 Fibrinogen levels; CESC trans rs1945213 0.694 rs9888298 chr11:55865704 T/C cg03929089 chr4:120376271 NA 0.78 7.5 0.42 9.59e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs4466137 0.953 rs974023 chr5:83014848 T/C cg16102102 chr5:83017553 HAPLN1 -0.51 -7.24 -0.41 4.94e-12 Prostate cancer; CESC cis rs3771570 1.000 rs62193197 chr2:242294301 G/A cg21155796 chr2:242212141 HDLBP 0.6 5.18 0.3 4.5e-7 Prostate cancer; CESC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg07870213 chr5:140052090 DND1 -0.62 -7.03 -0.4 1.8e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg07211511 chr3:129823064 LOC729375 -0.59 -7.28 -0.41 3.84e-12 Blood pressure (smoking interaction); CESC cis rs854765 0.647 rs7406744 chr17:17981938 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.64 9.07 0.49 2.69e-17 Total body bone mineral density; CESC cis rs7582720 1.000 rs72932566 chr2:203855342 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs4704187 0.687 rs10058460 chr5:74498715 C/T cg03227963 chr5:74354835 NA 0.29 5.27 0.31 2.77e-7 Response to amphetamines; CESC cis rs7843479 1.000 rs13248727 chr8:21842063 T/C cg17168535 chr8:21777572 XPO7 0.49 6.81 0.39 6.44e-11 Mean corpuscular volume; CESC cis rs939658 0.805 rs35484723 chr15:79441032 A/G cg17916960 chr15:79447300 NA -0.35 -5.98 -0.34 7.25e-9 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09467020 chr12:125398629 UBC -0.59 -6.92 -0.39 3.33e-11 Gut microbiome composition (summer); CESC cis rs6582630 0.519 rs9738104 chr12:38338459 A/C cg26384229 chr12:38710491 ALG10B 0.74 10.66 0.55 2.58e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg11764359 chr7:65958608 NA 0.79 11.17 0.57 5.2e-24 Aortic root size; CESC trans rs61931739 0.500 rs11524949 chr12:34435551 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.16 0.35 2.66e-9 Morning vs. evening chronotype; CESC cis rs854765 0.583 rs7207043 chr17:17819188 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.34 0.41 2.67e-12 Total body bone mineral density; CESC cis rs11209002 0.545 rs2093332 chr1:67531974 G/A cg02640540 chr1:67518911 SLC35D1 0.48 5.47 0.32 1.04e-7 Crohn's disease; CESC cis rs11696501 0.694 rs6094184 chr20:44256575 G/A cg11783356 chr20:44313418 WFDC10B -0.35 -5.4 -0.31 1.49e-7 Brain structure; CESC cis rs8092503 1.000 rs7243785 chr18:52475162 C/T cg12377874 chr18:52495404 RAB27B -0.38 -6.37 -0.36 8.48e-10 Childhood body mass index; CESC cis rs7264396 0.635 rs6088971 chr20:34535373 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.59 7.07 0.4 1.4e-11 Total cholesterol levels; CESC cis rs9815354 0.904 rs73073235 chr3:42012693 C/A cg03022575 chr3:42003672 ULK4 0.68 6.13 0.35 3.21e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs4699052 0.928 rs2126473 chr4:104141533 G/C cg16532752 chr4:104119610 CENPE -0.39 -5.35 -0.31 1.9e-7 Testicular germ cell tumor; CESC cis rs74781061 1.000 rs4887166 chr15:74897598 C/G cg17294928 chr15:75287854 SCAMP5 -0.51 -5.46 -0.32 1.11e-7 Endometriosis; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg15835091 chr22:16468340 NA -0.47 -6.79 -0.38 7.3e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs8027181 0.839 rs8033073 chr15:73051093 G/A cg25632853 chr15:73088954 NA 0.31 5.63 0.33 4.59e-8 Triglyceride levels; CESC cis rs12822507 0.868 rs12830917 chr12:12792516 C/A cg04607235 chr12:12878440 APOLD1 -0.51 -6.62 -0.38 2.04e-10 Systemic lupus erythematosus; CESC cis rs614226 0.935 rs588132 chr12:121024066 A/G cg01236616 chr12:121019343 POP5 1.49 18.26 0.75 8.44e-49 Type 1 diabetes nephropathy; CESC cis rs16858210 0.648 rs57604063 chr3:183578689 A/T cg25686905 chr3:183603175 PARL -0.32 -5.6 -0.33 5.31e-8 Menopause (age at onset); CESC cis rs7726839 0.540 rs74553517 chr5:665671 C/T cg16447950 chr5:562315 NA -0.62 -6.54 -0.37 3.09e-10 Obesity-related traits; CESC cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs5758659 0.714 rs2284087 chr22:42485671 T/C cg15557168 chr22:42548783 NA 0.42 6.54 0.37 3.15e-10 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08113639 chr17:17061915 MPRIP -0.55 -6.57 -0.37 2.61e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18163227 chr17:74554350 SNORD1C -0.54 -6.02 -0.35 5.84e-9 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -7.82 -0.43 1.27e-13 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24545466 chr11:33891541 LMO2 -0.57 -6.49 -0.37 4.29e-10 Gut microbiome composition (summer); CESC trans rs6964833 0.935 rs35735900 chr7:74066227 T/C cg07504079 chr7:72649617 NCF1B -0.55 -6.23 -0.36 1.79e-9 Menarche (age at onset); CESC cis rs6866344 0.570 rs59259518 chr5:178142628 C/T cg03877680 chr5:178157825 ZNF354A 0.84 10.06 0.53 2.24e-20 Neutrophil percentage of white cells; CESC cis rs6060717 0.536 rs11697851 chr20:34524494 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.58 0.32 5.82e-8 Hip circumference adjusted for BMI; CESC cis rs12893668 0.703 rs34896432 chr14:104027995 C/T cg24130564 chr14:104152367 KLC1 -0.46 -5.74 -0.33 2.63e-8 Reticulocyte count; CESC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs753778 1.000 rs4961257 chr8:142232704 A/G cg23750338 chr8:142222470 SLC45A4 -0.39 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7605827 0.930 rs11689686 chr2:15527659 C/T cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs9287719 0.934 rs4622695 chr2:10744327 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs208520 0.754 rs1100989 chr6:66880532 G/A cg07460842 chr6:66804631 NA -1.0 -12.97 -0.62 3.95e-30 Exhaled nitric oxide output; CESC cis rs2718058 0.519 rs2598071 chr7:37875347 G/A cg24998770 chr7:37888106 TXNDC3 0.37 5.67 0.33 3.82e-8 Alzheimer's disease (late onset); CESC cis rs12142240 0.698 rs17361819 chr1:46828109 A/G cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.12e-9 Menopause (age at onset); CESC cis rs2243480 0.666 rs1880311 chr7:65276752 G/C cg25894440 chr7:65020034 NA 0.66 5.55 0.32 6.86e-8 Diabetic kidney disease; CESC cis rs2204008 0.744 rs11181635 chr12:38378420 C/T cg13010199 chr12:38710504 ALG10B 0.54 6.82 0.39 6e-11 Bladder cancer; CESC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg23048001 chr7:2026167 MAD1L1 0.47 6.16 0.35 2.62e-9 Bipolar disorder and schizophrenia; CESC cis rs9790314 0.967 rs10804790 chr3:161039300 T/A cg04691961 chr3:161091175 C3orf57 -0.43 -5.56 -0.32 6.47e-8 Morning vs. evening chronotype; CESC cis rs12541635 0.966 rs2132471 chr8:107000963 G/A cg10147462 chr8:107024639 NA 0.4 5.71 0.33 2.99e-8 Age of smoking initiation; CESC cis rs7568458 0.660 rs2289972 chr2:85766545 C/T cg02493740 chr2:85810744 VAMP5 -0.57 -8.37 -0.46 3.28e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15130565 chr3:61546275 PTPRG -0.46 -6.18 -0.35 2.43e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg12311346 chr5:56204834 C5orf35 -0.71 -8.52 -0.46 1.21e-15 Initial pursuit acceleration; CESC cis rs5753037 0.586 rs140120 chr22:30138548 T/C cg01021169 chr22:30184971 ASCC2 -0.47 -6.56 -0.37 2.85e-10 Type 1 diabetes; CESC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg20607287 chr7:12443886 VWDE -0.77 -9.04 -0.49 3.38e-17 Coronary artery disease; CESC cis rs4332037 0.576 rs62434668 chr7:1866901 G/A cg13880726 chr7:1868755 MAD1L1 -0.51 -5.09 -0.3 6.93e-7 Bipolar disorder; CESC cis rs36051895 0.664 rs12344629 chr9:5109208 C/T cg02405213 chr9:5042618 JAK2 -0.51 -6.09 -0.35 3.86e-9 Pediatric autoimmune diseases; CESC cis rs2228479 0.850 rs62052711 chr16:89855100 C/A cg19635926 chr16:89946313 TCF25 0.67 5.08 0.3 7.19e-7 Skin colour saturation; CESC cis rs977987 0.806 rs4888389 chr16:75395228 T/C cg03315344 chr16:75512273 CHST6 0.39 5.64 0.33 4.3e-8 Dupuytren's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27373220 chr10:465035 DIP2C 0.51 6.66 0.38 1.57e-10 Fibrinogen levels; CESC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg11211951 chr8:145729740 GPT -0.41 -7.13 -0.4 9.28e-12 Age at first birth; CESC cis rs7918232 0.574 rs10458708 chr10:27455605 C/T cg14442939 chr10:27389572 ANKRD26 0.79 11.75 0.59 5.91e-26 Breast cancer; CESC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7582720 1.000 rs72936348 chr2:204064839 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.84 7.17 0.4 7.7e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs2795502 1.000 rs3121323 chr10:43377166 A/G cg27426351 chr10:43362370 NA -0.45 -5.8 -0.34 1.92e-8 Blood protein levels; CESC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg01988459 chr11:68622903 NA 0.46 6.33 0.36 1.02e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.76 0.38 8.85e-11 Bipolar disorder; CESC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg06505273 chr16:24850292 NA -0.53 -6.45 -0.37 5.32e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4474465 0.850 rs7127028 chr11:78262324 A/G cg27205649 chr11:78285834 NARS2 0.41 5.12 0.3 6.01e-7 Alzheimer's disease (survival time); CESC cis rs9325144 0.650 rs6582631 chr12:38744135 T/C cg26384229 chr12:38710491 ALG10B 0.56 7.9 0.44 7.59e-14 Morning vs. evening chronotype; CESC cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg10523679 chr1:76189770 ACADM 0.69 6.83 0.39 5.86e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9325144 0.957 rs1995419 chr12:38950726 C/G cg26384229 chr12:38710491 ALG10B 0.51 5.89 0.34 1.19e-8 Morning vs. evening chronotype; CESC cis rs34330 0.562 rs10492235 chr12:12851339 T/G cg09462578 chr12:12878428 APOLD1 -0.8 -8.44 -0.46 2.07e-15 Systemic lupus erythematosus; CESC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg05025164 chr4:1340916 KIAA1530 0.63 8.74 0.47 2.81e-16 Longevity; CESC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg03609598 chr5:56110824 MAP3K1 -0.51 -5.32 -0.31 2.22e-7 Initial pursuit acceleration; CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.44 5.41 0.32 1.39e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.53 5.03 0.3 8.86e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs2204008 0.837 rs12370891 chr12:37984531 A/G cg13010199 chr12:38710504 ALG10B 0.53 6.61 0.38 2.1e-10 Bladder cancer; CESC cis rs4319547 0.656 rs10846664 chr12:122823777 C/T cg05707623 chr12:122985044 ZCCHC8 0.49 5.72 0.33 2.82e-8 Body mass index; CESC cis rs6740322 0.748 rs13420649 chr2:43463637 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -8.09 -0.45 2.16e-14 Coronary artery disease; CESC cis rs10752881 1.000 rs10737235 chr1:182971816 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.37 0.63 1.69e-31 Colorectal cancer; CESC cis rs17021463 0.872 rs10856909 chr4:95268748 C/G cg11021082 chr4:95130006 SMARCAD1 0.51 7.56 0.42 6.78e-13 Testicular germ cell tumor; CESC cis rs9926296 0.607 rs11076629 chr16:89875259 T/C cg04287289 chr16:89883240 FANCA 0.64 8.57 0.47 8.48e-16 Vitiligo; CESC cis rs3126085 0.935 rs7540844 chr1:152230586 A/T cg03465714 chr1:152285911 FLG -0.44 -5.52 -0.32 8.23e-8 Atopic dermatitis; CESC cis rs7917772 0.582 rs4917975 chr10:104358407 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.63 0.33 4.48e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs12136530 0.593 rs4911988 chr1:19724480 C/T cg01832549 chr1:19774989 CAPZB -0.45 -6.37 -0.36 8.21e-10 Lead levels in blood; CESC cis rs9611519 0.732 rs1883826 chr22:41703428 G/A cg03806693 chr22:41940476 POLR3H -0.76 -8.65 -0.47 5.19e-16 Neuroticism; CESC cis rs2011503 0.941 rs76944848 chr19:19417512 C/T cg11584989 chr19:19387371 SF4 0.67 7.3 0.41 3.31e-12 Bipolar disorder; CESC cis rs35110281 0.805 rs8131005 chr21:45041954 T/C cg04455712 chr21:45112962 RRP1B 0.41 6.5 0.37 3.86e-10 Mean corpuscular volume; CESC cis rs2204008 0.715 rs12368462 chr12:38336116 C/G cg26384229 chr12:38710491 ALG10B 0.72 10.68 0.55 2.23e-22 Bladder cancer; CESC cis rs7726839 0.540 rs3792720 chr5:643028 T/G cg16447950 chr5:562315 NA -0.57 -6.22 -0.36 1.92e-9 Obesity-related traits; CESC cis rs7927771 0.542 rs6485775 chr11:47773518 A/G cg18512352 chr11:47633146 NA -0.34 -5.37 -0.31 1.74e-7 Subjective well-being; CESC cis rs72945132 0.882 rs7114200 chr11:70186099 C/A cg00319359 chr11:70116639 PPFIA1 0.79 7.45 0.42 1.3e-12 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02070114 chr5:139555300 C5orf32 -0.47 -6.57 -0.37 2.67e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg06873352 chr17:61820015 STRADA 0.49 7.15 0.4 8.68e-12 Height; CESC cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg22875332 chr1:76189707 ACADM 0.58 6.54 0.37 3.21e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs67311347 0.568 rs57287242 chr3:40335538 T/C cg24209194 chr3:40518798 ZNF619 0.37 5.06 0.3 7.68e-7 Renal cell carcinoma; CESC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs208520 0.909 rs9453672 chr6:66991431 A/G cg07460842 chr6:66804631 NA 0.78 8.94 0.48 6.96e-17 Exhaled nitric oxide output; CESC cis rs1707322 1.000 rs785506 chr1:46540652 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.55 -0.32 7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg00129232 chr17:37814104 STARD3 0.56 7.28 0.41 3.73e-12 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23486179 chr3:49466665 NICN1 0.56 6.04 0.35 5.21e-9 Gut microbiome composition (summer); CESC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg16049864 chr8:95962084 TP53INP1 -0.56 -8.46 -0.46 1.84e-15 Type 2 diabetes; CESC cis rs6466055 0.669 rs6948885 chr7:104664879 C/T cg04380332 chr7:105027541 SRPK2 -0.37 -5.26 -0.31 3e-7 Schizophrenia; CESC cis rs11122272 0.735 rs2790889 chr1:231520240 C/A cg06096015 chr1:231504339 EGLN1 0.43 6.13 0.35 3.23e-9 Hemoglobin concentration; CESC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg06634786 chr22:41940651 POLR3H 0.58 6.21 0.36 2.04e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs703842 1.000 rs11172344 chr12:58193448 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.69 8.87 0.48 1.09e-16 Multiple sclerosis; CESC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg16325326 chr1:53192061 ZYG11B -0.94 -16.1 -0.7 3.83e-41 Monocyte count; CESC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg07936489 chr17:37558343 FBXL20 0.76 10.71 0.55 1.83e-22 Glomerular filtration rate (creatinine); CESC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg26314531 chr2:26401878 FAM59B -0.82 -9.28 -0.5 6.29e-18 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg19193384 chr17:30244184 NA -0.66 -6.92 -0.39 3.33e-11 Hip circumference adjusted for BMI; CESC trans rs561341 1.000 rs72823787 chr17:30283809 A/T cg20587970 chr11:113659929 NA -1.48 -19.42 -0.77 7.47e-53 Hip circumference adjusted for BMI; CESC cis rs79349575 0.749 rs2270574 chr17:47022270 C/T cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg17143192 chr8:8559678 CLDN23 0.71 8.52 0.46 1.23e-15 Obesity-related traits; CESC cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg11752832 chr7:134001865 SLC35B4 -0.54 -6.96 -0.39 2.67e-11 Mean platelet volume; CESC cis rs4969178 0.600 rs2376583 chr17:76402105 A/T cg05887092 chr17:76393375 PGS1 0.7 11.95 0.59 1.31e-26 HDL cholesterol levels; CESC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg08888203 chr3:10149979 C3orf24 0.46 5.94 0.34 9.15e-9 Alzheimer's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21767135 chr3:3169141 TRNT1 -0.49 -6.6 -0.38 2.22e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7474896 0.537 rs2749588 chr10:38269457 C/G cg25427524 chr10:38739819 LOC399744 -0.49 -5.53 -0.32 7.61e-8 Obesity (extreme); CESC cis rs1023500 0.573 rs8135801 chr22:42475568 A/G cg04733989 chr22:42467013 NAGA -0.78 -11.89 -0.59 2.08e-26 Schizophrenia; CESC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.61 0.33 5.12e-8 Bipolar disorder; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg00959118 chr1:169455055 SLC19A2 -0.44 -6.08 -0.35 4.15e-9 Recombination measurement; CESC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 9.05 0.49 3.09e-17 Platelet count; CESC cis rs9896933 0.832 rs75552659 chr17:80804630 G/A cg19500275 chr17:80737654 TBCD 0.63 6.09 0.35 3.89e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00081347 chr17:78188837 SGSH 0.48 6.68 0.38 1.37e-10 Fibrinogen levels; CESC cis rs2439831 1.000 rs565007 chr15:43716641 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.61 0.55 3.7e-22 Lung cancer in ever smokers; CESC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg18337363 chr3:52569053 NT5DC2 0.29 5.36 0.31 1.85e-7 Bipolar disorder; CESC cis rs8067354 0.507 rs72840511 chr17:57806011 G/T cg02344993 chr17:57696989 CLTC 0.58 6.07 0.35 4.5e-9 Hemoglobin concentration; CESC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg19346786 chr7:2764209 NA -0.41 -6.01 -0.35 6e-9 Height; CESC cis rs7084402 0.967 rs1649076 chr10:60294061 A/T cg07615347 chr10:60278583 BICC1 0.6 9.42 0.5 2.35e-18 Refractive error; CESC cis rs644799 0.664 rs603625 chr11:95554283 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 10.55 0.54 5.85e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7264396 0.790 rs2295355 chr20:34252654 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.83 -0.59 3.29e-26 Total cholesterol levels; CESC cis rs9300255 0.679 rs58809476 chr12:123724880 C/T cg00376283 chr12:123451042 ABCB9 -0.6 -6.32 -0.36 1.12e-9 Neutrophil percentage of white cells; CESC cis rs7520050 0.966 rs785494 chr1:46586626 C/A cg24296786 chr1:45957014 TESK2 0.4 5.06 0.3 8.02e-7 Red blood cell count;Reticulocyte count; CESC cis rs7937682 0.889 rs493810 chr11:111491888 G/T cg22437258 chr11:111473054 SIK2 0.72 9.66 0.51 4.24e-19 Primary sclerosing cholangitis; CESC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg06456125 chr7:65229604 NA 0.4 5.25 0.31 3.1e-7 Aortic root size; CESC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 8.06 0.44 2.67e-14 Intelligence (multi-trait analysis); CESC cis rs2637266 0.783 rs860167 chr10:78532936 A/G cg18941641 chr10:78392320 NA 0.39 7.45 0.42 1.36e-12 Pulmonary function; CESC cis rs910316 0.763 rs6574205 chr14:75453039 G/C cg08847533 chr14:75593920 NEK9 0.92 16.13 0.7 2.98e-41 Height; CESC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg04511125 chr2:88470314 THNSL2 0.68 6.66 0.38 1.61e-10 Plasma clusterin levels; CESC cis rs11638352 1.000 rs4924727 chr15:44280609 T/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.63 -5.44 -0.32 1.23e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs4727027 0.625 rs75129390 chr7:148846775 T/A cg23583168 chr7:148888333 NA -0.74 -10.73 -0.55 1.51e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2070433 1.000 rs2070433 chr21:47961386 G/A cg12379764 chr21:47803548 PCNT 0.61 7.25 0.41 4.56e-12 Lymphocyte counts; CESC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.77 8.57 0.47 8.66e-16 Alzheimer's disease; CESC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC trans rs6951245 0.832 rs10266519 chr7:1142977 C/T cg13565492 chr6:43139072 SRF -0.65 -6.73 -0.38 1.05e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3762318 0.853 rs6666144 chr1:67603825 A/T cg17031739 chr1:67600172 NA 0.53 5.11 0.3 6.16e-7 Leprosy; CESC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg02099474 chr7:1027990 CYP2W1 -0.34 -5.06 -0.3 7.67e-7 Longevity;Endometriosis; CESC cis rs244293 1.000 rs244295 chr17:53242899 T/A cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.09 -0.3 6.8e-7 Menarche (age at onset); CESC cis rs7635838 0.587 rs347591 chr3:11290122 G/T cg00170343 chr3:11313890 ATG7 0.56 8.02 0.44 3.45e-14 HDL cholesterol; CESC cis rs11077998 0.935 rs9893826 chr17:80511128 C/T cg10255544 chr17:80519551 FOXK2 0.53 8.6 0.47 7.31e-16 Reticulocyte fraction of red cells; CESC cis rs258892 0.895 rs266437 chr5:72167441 G/C cg21869765 chr5:72125136 TNPO1 0.48 6.0 0.35 6.61e-9 Small cell lung carcinoma; CESC trans rs7819412 0.521 rs4451268 chr8:11034859 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -6.09 -0.35 3.87e-9 Triglycerides; CESC cis rs4862750 0.872 rs13101380 chr4:187894744 G/A cg11301795 chr4:187892539 NA -0.81 -14.21 -0.66 1.94e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs1559088 0.600 rs7255229 chr19:33562807 A/G cg17764715 chr19:33622953 WDR88 0.6 8.48 0.46 1.65e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs963731 0.579 rs2060987 chr2:39282079 A/G cg04010122 chr2:39346883 SOS1 -0.7 -5.54 -0.32 7.3e-8 Corticobasal degeneration; CESC cis rs7851660 0.967 rs3758251 chr9:100613700 G/C cg13688889 chr9:100608707 NA -0.68 -10.54 -0.54 6.55e-22 Strep throat; CESC cis rs2637266 0.703 rs7920374 chr10:78455861 T/C cg18941641 chr10:78392320 NA 0.4 7.32 0.41 2.91e-12 Pulmonary function; CESC cis rs62229266 0.773 rs878606 chr21:37406692 G/A cg08632701 chr21:37451849 NA -0.38 -5.16 -0.3 4.93e-7 Mitral valve prolapse; CESC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg18032046 chr6:28092343 ZSCAN16 -0.43 -5.5 -0.32 8.75e-8 Cardiac Troponin-T levels; CESC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg08470875 chr2:26401718 FAM59B -0.74 -7.65 -0.43 3.83e-13 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs10057299 chr5:242135 C/T cg22857025 chr5:266934 NA -1.27 -18.37 -0.75 3.49e-49 Breast cancer; CESC cis rs6754311 0.509 rs12616520 chr2:136516748 A/T cg15123519 chr2:136567270 LCT 0.31 5.33 0.31 2.14e-7 Mosquito bite size; CESC cis rs796364 0.774 rs112564437 chr2:201074048 G/C cg23649088 chr2:200775458 C2orf69 -0.49 -5.6 -0.33 5.24e-8 Schizophrenia; CESC cis rs67311347 0.955 rs6764102 chr3:40378153 C/G cg09455208 chr3:40491958 NA 0.49 8.42 0.46 2.41e-15 Renal cell carcinoma; CESC cis rs7208859 0.623 rs73269945 chr17:29108759 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg05313129 chr8:58192883 C8orf71 -0.54 -6.22 -0.36 1.94e-9 Developmental language disorder (linguistic errors); CESC cis rs4834770 0.746 rs2389747 chr4:120236102 C/T cg09307838 chr4:120376055 NA 0.51 6.46 0.37 4.87e-10 Blood protein levels; CESC cis rs4727027 0.704 rs13221837 chr7:148903597 C/T cg23583168 chr7:148888333 NA -0.92 -16.79 -0.72 1.42e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg18099408 chr3:52552593 STAB1 -0.32 -5.19 -0.3 4.18e-7 Bipolar disorder; CESC cis rs2637266 0.967 rs12244619 chr10:78352502 C/T cg18941641 chr10:78392320 NA 0.41 7.59 0.42 5.38e-13 Pulmonary function; CESC cis rs3820928 0.874 rs7421491 chr2:227839278 C/A cg05526886 chr2:227700861 RHBDD1 -0.43 -5.3 -0.31 2.4e-7 Pulmonary function; CESC cis rs826838 1.000 rs11514441 chr12:38775190 C/T cg13010199 chr12:38710504 ALG10B 0.6 8.56 0.47 9.34e-16 Heart rate; CESC cis rs7727544 0.735 rs4705933 chr5:131678412 G/A cg07395648 chr5:131743802 NA -0.45 -6.02 -0.35 5.83e-9 Blood metabolite levels; CESC cis rs916888 0.773 rs199534 chr17:44824213 T/G cg17911788 chr17:44343683 NA -0.6 -7.67 -0.43 3.31e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs2018683 0.624 rs6462119 chr7:29003725 G/C cg19402173 chr7:128379420 CALU -0.54 -6.71 -0.38 1.15e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg03060546 chr3:49711283 APEH 0.49 6.04 0.35 5.08e-9 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05433637 chr1:1510598 SSU72 -0.64 -7.66 -0.43 3.51e-13 Gut microbiome composition (summer); CESC trans rs7615952 0.800 rs12489350 chr3:125644116 T/C cg07211511 chr3:129823064 LOC729375 -1.12 -15.9 -0.7 1.92e-40 Blood pressure (smoking interaction); CESC cis rs7945705 0.935 rs10769971 chr11:8925276 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.53 8.36 0.46 3.52e-15 Hemoglobin concentration; CESC cis rs11648796 0.757 rs66649828 chr16:766078 A/G cg27144592 chr16:783916 NARFL 0.44 6.14 0.35 2.98e-9 Height; CESC cis rs3106136 0.609 rs11097407 chr4:95146135 C/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.32 -0.36 1.13e-9 Capecitabine sensitivity; CESC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.26e-11 Skin colour saturation; CESC cis rs7833986 0.501 rs2719257 chr8:56940173 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.6 7.52 0.42 8.41e-13 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01989157 chr22:40742702 ADSL 0.46 6.36 0.36 8.63e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10465746 0.967 rs12407641 chr1:84368115 T/C cg10977910 chr1:84465055 TTLL7 0.47 6.36 0.36 8.7e-10 Obesity-related traits; CESC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg22105103 chr4:187893119 NA -0.46 -6.56 -0.37 2.81e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9733 0.596 rs12089989 chr1:150715782 G/A cg09365446 chr1:150670422 GOLPH3L 0.36 5.03 0.3 9.08e-7 Tonsillectomy; CESC cis rs939658 0.805 rs8024813 chr15:79427260 A/G cg17916960 chr15:79447300 NA -0.38 -6.22 -0.36 1.94e-9 Refractive error; CESC cis rs10876993 0.890 rs4760165 chr12:58063801 C/T cg18357645 chr12:58087776 OS9 0.64 10.34 0.54 2.75e-21 Celiac disease or Rheumatoid arthritis; CESC trans rs7786808 0.552 rs896762 chr7:158182029 A/G cg03441993 chr4:55093323 NA -0.41 -6.28 -0.36 1.37e-9 Obesity-related traits; CESC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg24101359 chr6:42928495 GNMT 0.62 9.51 0.5 1.22e-18 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg03452623 chr4:187889614 NA -0.88 -16.15 -0.7 2.59e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs1957429 0.808 rs763346 chr14:65330386 A/G cg23373153 chr14:65346875 NA -0.85 -9.23 -0.49 8.96e-18 Pediatric areal bone mineral density (radius); CESC trans rs7246657 0.943 rs10406177 chr19:37907947 G/A cg24637308 chr11:6592297 DNHD1 0.54 6.29 0.36 1.27e-9 Coronary artery calcification; CESC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg27494647 chr7:150038898 RARRES2 0.42 5.04 0.3 8.8e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs477692 0.905 rs544217 chr10:131420584 A/G cg05714579 chr10:131428358 MGMT 0.55 7.86 0.43 9.83e-14 Response to temozolomide; CESC trans rs9325144 0.555 rs4550281 chr12:38689937 A/G cg23762105 chr12:34175262 ALG10 -0.48 -6.51 -0.37 3.66e-10 Morning vs. evening chronotype; CESC cis rs7301826 0.627 rs10773823 chr12:131294501 C/T cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC cis rs10489525 1.000 rs10489525 chr1:115263685 A/G cg12756093 chr1:115239321 AMPD1 0.47 5.73 0.33 2.7e-8 Autism; CESC cis rs2708240 0.936 rs2710099 chr7:147574666 G/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.23e-8 QT interval (drug interaction); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg09408520 chr2:157188965 NR4A2 -0.47 -6.73 -0.38 1.02e-10 Vertical cup-disc ratio; CESC cis rs1008375 0.898 rs61047804 chr4:17593965 G/A cg02297831 chr4:17616191 MED28 0.51 6.27 0.36 1.43e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11098499 0.874 rs12502503 chr4:120116255 C/T cg25214090 chr10:38739885 LOC399744 0.61 8.05 0.44 2.83e-14 Corneal astigmatism; CESC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg17340268 chr14:105411764 AHNAK2 -0.52 -6.93 -0.39 3.19e-11 Rheumatoid arthritis; CESC cis rs873946 0.564 rs12242672 chr10:134555609 A/T cg27286337 chr10:134555280 INPP5A 0.59 6.98 0.39 2.4e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4664308 1.000 rs4664308 chr2:160917497 A/G cg03641300 chr2:160917029 PLA2R1 -0.67 -10.08 -0.53 1.88e-20 Idiopathic membranous nephropathy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03618215 chr12:133365750 GOLGA3 0.5 6.59 0.38 2.36e-10 Fibrinogen levels; CESC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg11941060 chr3:133502564 NA -0.44 -5.66 -0.33 3.93e-8 Iron status biomarkers; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11814422 chr18:47018265 SNORD58A;RPL17;SNORD58B 0.5 6.88 0.39 4.21e-11 Systemic lupus erythematosus; CESC cis rs7177699 0.525 rs7402376 chr15:79113570 A/G cg04896959 chr15:78267971 NA 0.32 5.13 0.3 5.72e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg07507251 chr3:52567010 NT5DC2 0.34 5.82 0.34 1.73e-8 Electroencephalogram traits; CESC cis rs10752881 1.000 rs4304541 chr1:182970238 G/T ch.1.3577855R chr1:183094577 LAMC1 0.86 13.7 0.64 1.17e-32 Colorectal cancer; CESC cis rs7208859 0.623 rs383436 chr17:28959179 A/G cg19761014 chr17:28927070 LRRC37B2 0.86 6.49 0.37 4.09e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6964587 1.000 rs9785013 chr7:91674302 G/A cg17063962 chr7:91808500 NA 0.55 7.49 0.42 1.01e-12 Breast cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg27556566 chr18:29671984 RNF138 0.53 7.27 0.41 3.94e-12 Systemic lupus erythematosus; CESC trans rs7572644 0.640 rs6547820 chr2:28281545 G/A cg07673866 chr10:94351376 KIF11 0.51 6.02 0.35 5.73e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CESC cis rs727505 0.954 rs59379598 chr7:124596903 C/G cg23710748 chr7:124431027 NA -0.45 -7.08 -0.4 1.27e-11 Lewy body disease; CESC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs208520 0.874 rs208470 chr6:66916402 G/A cg07460842 chr6:66804631 NA -0.87 -10.57 -0.54 5.25e-22 Exhaled nitric oxide output; CESC cis rs3105593 0.933 rs3131595 chr15:50877583 C/T cg08437265 chr15:50716283 USP8 0.41 5.28 0.31 2.68e-7 QT interval; CESC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg00149659 chr3:10157352 C3orf10 0.61 6.61 0.38 2.1e-10 Alzheimer's disease; CESC cis rs4689388 0.926 rs4688986 chr4:6285797 C/A cg00701064 chr4:6280414 WFS1 0.77 14.09 0.65 5.09e-34 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4132509 1.000 rs2881275 chr1:243918313 G/C cg21452805 chr1:244014465 NA 0.49 6.13 0.35 3.2e-9 RR interval (heart rate); CESC cis rs11842874 1.000 rs118021693 chr13:113688746 C/G cg00053927 chr13:113699014 MCF2L -0.65 -5.08 -0.3 7.3e-7 Osteoarthritis; CESC cis rs7264396 0.836 rs6120995 chr20:34185726 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -7.1 -0.4 1.15e-11 Total cholesterol levels; CESC cis rs10028773 0.556 rs4473640 chr4:120260437 G/A cg09307838 chr4:120376055 NA 0.76 10.33 0.54 3.09e-21 Educational attainment; CESC trans rs877282 1.000 rs877281 chr10:771557 T/G cg22713356 chr15:30763199 NA 1.26 12.75 0.62 2.39e-29 Uric acid levels; CESC cis rs9815354 0.812 rs17280952 chr3:41810834 T/C cg03022575 chr3:42003672 ULK4 0.68 6.06 0.35 4.7e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6087990 0.842 rs6119279 chr20:31330612 A/G cg13636640 chr20:31349939 DNMT3B 0.82 14.5 0.67 1.72e-35 Ulcerative colitis; CESC cis rs6545883 0.894 rs7602859 chr2:61458206 A/T cg15711740 chr2:61764176 XPO1 0.4 5.12 0.3 5.86e-7 Tuberculosis; CESC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg06108461 chr20:60628389 TAF4 -0.92 -14.55 -0.67 1.22e-35 Body mass index; CESC cis rs4604732 0.642 rs6426252 chr1:247639887 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.36 5.4 0.31 1.48e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7520050 0.966 rs4073846 chr1:46462881 C/T cg24296786 chr1:45957014 TESK2 -0.44 -5.59 -0.32 5.53e-8 Red blood cell count;Reticulocyte count; CESC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.962 rs35031906 chr6:149998574 T/C cg13206674 chr6:150067644 NUP43 0.4 5.53 0.32 7.84e-8 Lung cancer; CESC trans rs4711350 0.862 rs597723 chr6:33694079 C/T cg09350274 chr5:137610396 GFRA3 -0.41 -6.14 -0.35 3.06e-9 Schizophrenia; CESC trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21659725 chr3:3221576 CRBN -0.83 -13.61 -0.64 2.43e-32 Intelligence (multi-trait analysis); CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg11235426 chr6:292522 DUSP22 -0.72 -9.39 -0.5 2.88e-18 Menopause (age at onset); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg25225632 chr5:1324090 CLPTM1L 0.44 6.21 0.36 1.98e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg11345693 chr17:79170810 AZI1 -0.33 -5.31 -0.31 2.36e-7 Frontotemporal dementia; CESC cis rs4900538 0.855 rs12586378 chr14:102853150 T/C cg18135206 chr14:102964638 TECPR2 -0.7 -8.72 -0.47 3.17e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs4604732 0.578 rs12040725 chr1:247644697 T/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.27 0.31 2.79e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs113835537 0.935 rs76228630 chr11:66458676 T/C cg24851651 chr11:66362959 CCS 0.66 5.87 0.34 1.27e-8 Airway imaging phenotypes; CESC cis rs1559088 1.000 rs28840147 chr19:33561976 A/G cg17764715 chr19:33622953 WDR88 0.47 5.82 0.34 1.67e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.5 -5.43 -0.32 1.24e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg25072359 chr17:41440525 NA 0.47 6.36 0.36 8.86e-10 Menopause (age at onset); CESC cis rs13064411 0.696 rs7624994 chr3:113228009 T/C cg18753928 chr3:113234510 CCDC52 -0.5 -6.13 -0.35 3.23e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs2228479 0.850 rs11641147 chr16:89813589 C/T cg14709524 chr16:89940631 TCF25 0.95 7.1 0.4 1.18e-11 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14084056 chr12:48744539 ZNF641 0.6 6.74 0.38 9.57e-11 Gut microbiome composition (summer); CESC cis rs8067354 0.645 rs16943838 chr17:57839604 C/T cg02344993 chr17:57696989 CLTC 0.57 5.97 0.34 7.53e-9 Hemoglobin concentration; CESC cis rs7582720 0.943 rs115827549 chr2:203725678 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs10791323 0.569 rs2156679 chr11:133742304 C/T cg15485101 chr11:133734466 NA 0.3 5.22 0.31 3.56e-7 Childhood ear infection; CESC cis rs6964587 0.839 rs2049314 chr7:91464134 C/T cg17063962 chr7:91808500 NA 0.5 6.34 0.36 1.01e-9 Breast cancer; CESC cis rs1062177 0.724 rs2964590 chr5:151118146 C/G cg12924095 chr5:151150029 G3BP1 -0.42 -5.15 -0.3 5.06e-7 Preschool internalizing problems; CESC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg13393036 chr8:95962371 TP53INP1 -0.51 -11.07 -0.56 1.14e-23 Type 2 diabetes; CESC cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg13880726 chr7:1868755 MAD1L1 0.53 7.14 0.4 8.82e-12 Bipolar disorder and schizophrenia; CESC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg06505273 chr16:24850292 NA 0.51 6.16 0.35 2.69e-9 Intelligence (multi-trait analysis); CESC cis rs4268898 0.679 rs2551181 chr2:24437548 C/T cg06627628 chr2:24431161 ITSN2 0.88 10.16 0.53 1.08e-20 Asthma; CESC cis rs9583531 0.689 rs2165418 chr13:111379365 G/T cg24331049 chr13:111365604 ING1 -0.69 -9.73 -0.51 2.41e-19 Coronary artery disease; CESC cis rs2204008 0.621 rs7302846 chr12:38072979 A/C cg26384229 chr12:38710491 ALG10B 0.44 5.93 0.34 9.45e-9 Bladder cancer; CESC cis rs6964587 0.597 rs975707 chr7:91874527 C/G cg17063962 chr7:91808500 NA 0.47 6.45 0.37 5.22e-10 Breast cancer; CESC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.77 10.96 0.56 2.68e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs6740322 0.895 rs10166994 chr2:43557977 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -7.35 -0.41 2.54e-12 Coronary artery disease; CESC cis rs644799 0.710 rs56384142 chr11:95502075 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.78 0.59 4.74e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg20151795 chr6:28129481 ZNF389 0.36 5.25 0.31 3.14e-7 Cardiac Troponin-T levels; CESC cis rs17125944 0.505 rs74620173 chr14:53194068 G/T cg13660082 chr14:53194042 PSMC6 -0.67 -6.02 -0.35 5.92e-9 Alzheimer's disease (late onset); CESC cis rs734999 0.545 rs7364820 chr1:2556709 G/A cg20673091 chr1:2541236 MMEL1 0.47 7.84 0.43 1.11e-13 Ulcerative colitis; CESC cis rs3857536 0.813 rs1029400 chr6:66952385 A/G cg07460842 chr6:66804631 NA -0.42 -5.11 -0.3 6.32e-7 Blood trace element (Cu levels); CESC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg12311346 chr5:56204834 C5orf35 -0.72 -8.75 -0.47 2.48e-16 Initial pursuit acceleration; CESC cis rs3806843 0.966 rs1030166 chr5:140185473 G/A cg26395211 chr5:140044315 WDR55 -0.42 -5.26 -0.31 2.96e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9300255 0.602 rs2682431 chr12:123703226 T/A cg19016782 chr12:123741754 C12orf65 -0.45 -6.55 -0.37 2.97e-10 Neutrophil percentage of white cells; CESC cis rs9611565 0.546 rs5758430 chr22:42109844 G/T cg03806693 chr22:41940476 POLR3H 1.05 11.94 0.59 1.39e-26 Vitiligo; CESC cis rs473651 0.935 rs520765 chr2:239354712 C/T cg18131467 chr2:239335373 ASB1 1.01 20.64 0.79 4.24e-57 Multiple system atrophy; CESC cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg06634786 chr22:41940651 POLR3H 0.7 7.11 0.4 1.07e-11 Vitiligo; CESC cis rs6060717 0.536 rs6058364 chr20:34507890 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -6.96 -0.39 2.63e-11 Hip circumference adjusted for BMI; CESC cis rs752010 0.695 rs12134166 chr1:42105867 C/T cg06885757 chr1:42089581 HIVEP3 0.48 7.77 0.43 1.73e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg19163074 chr7:65112434 INTS4L2 -0.41 -5.12 -0.3 6.01e-7 Aortic root size; CESC cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg25174290 chr11:3078921 CARS 0.56 7.59 0.42 5.55e-13 Longevity; CESC cis rs7809950 0.678 rs7803151 chr7:106934246 G/A cg23024343 chr7:107201750 COG5 -0.55 -7.0 -0.4 2.05e-11 Coronary artery disease; CESC cis rs7274811 0.652 rs291694 chr20:32000351 A/G cg21523528 chr20:32077966 CBFA2T2 -0.57 -6.59 -0.38 2.3e-10 Height; CESC cis rs4148883 0.689 rs2602861 chr4:100030896 C/T cg13256891 chr4:100009986 ADH5 0.54 7.11 0.4 1.07e-11 Alcohol dependence; CESC cis rs7247513 0.964 rs12979795 chr19:12717847 C/T cg01871581 chr19:12707946 ZNF490 0.85 14.06 0.65 6.27e-34 Bipolar disorder; CESC cis rs4268898 0.760 rs11125535 chr2:24528114 T/C cg06627628 chr2:24431161 ITSN2 0.58 7.34 0.41 2.59e-12 Asthma; CESC cis rs60843830 1.000 rs17713729 chr2:249092 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.87 11.76 0.59 5.66e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1728785 1.000 rs1170428 chr16:68603988 C/A cg02972257 chr16:68554789 NA -0.68 -7.59 -0.42 5.63e-13 Ulcerative colitis; CESC cis rs6430585 0.528 rs115469964 chr2:136696608 A/C cg07169764 chr2:136633963 MCM6 1.29 20.09 0.78 3.63e-55 Corneal structure; CESC cis rs34172651 0.537 rs8049014 chr16:24698903 A/G cg00339695 chr16:24857497 SLC5A11 0.45 5.98 0.34 7.15e-9 Intelligence (multi-trait analysis); CESC cis rs56104184 0.775 rs73061695 chr19:49399988 T/C cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7100689 0.646 rs1340376 chr10:82128963 A/G cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs8092503 0.536 rs12606833 chr18:52436115 C/T cg12377874 chr18:52495404 RAB27B 0.35 5.21 0.3 3.82e-7 Childhood body mass index; CESC cis rs1707322 0.721 rs4660314 chr1:46229885 T/C cg06784218 chr1:46089804 CCDC17 0.41 7.23 0.41 5.3e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4803468 1.000 rs1473248 chr19:41923314 C/T cg09537434 chr19:41945824 ATP5SL 1.1 20.39 0.78 3.13e-56 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00851154 chr1:26690578 ZNF683 -0.4 -6.06 -0.35 4.54e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12105361 chr19:10216875 PPAN-P2RY11;SNORD105;PPAN -0.64 -7.25 -0.41 4.62e-12 Gut microbiome composition (summer); CESC cis rs116095464 0.764 rs10069197 chr5:230822 G/C cg20965017 chr5:231967 SDHA -0.45 -5.08 -0.3 7.29e-7 Breast cancer; CESC cis rs7107174 1.000 rs731600 chr11:77963133 A/G cg02023728 chr11:77925099 USP35 0.43 6.33 0.36 1.03e-9 Testicular germ cell tumor; CESC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg18404041 chr3:52824283 ITIH1 -0.38 -6.52 -0.37 3.57e-10 Bipolar disorder; CESC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg05863683 chr7:1912471 MAD1L1 0.47 7.07 0.4 1.37e-11 Bipolar disorder and schizophrenia; CESC cis rs863345 0.904 rs954677 chr1:158543277 G/T cg12129480 chr1:158549410 OR10X1 -0.32 -6.46 -0.37 5.08e-10 Pneumococcal bacteremia; CESC trans rs9329221 0.935 rs3750311 chr8:10283602 C/A cg15556689 chr8:8085844 FLJ10661 -0.58 -6.62 -0.38 2e-10 Neuroticism; CESC cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg06636001 chr8:8085503 FLJ10661 -0.43 -5.29 -0.31 2.55e-7 Neuroticism; CESC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg07701084 chr6:150067640 NUP43 0.48 6.69 0.38 1.36e-10 Lung cancer; CESC cis rs11203032 0.831 rs10509567 chr10:90945756 G/A cg16672925 chr10:90967113 CH25H 0.68 6.99 0.39 2.24e-11 Heart failure; CESC cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg21395723 chr22:39101663 GTPBP1 0.45 5.64 0.33 4.3e-8 Menopause (age at onset); CESC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg05863683 chr7:1912471 MAD1L1 0.4 5.91 0.34 1.04e-8 Schizophrenia; CESC cis rs1008375 0.966 rs4698638 chr4:17632988 G/C cg15017067 chr4:17643749 FAM184B 0.36 5.19 0.3 4.25e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs3942852 0.688 rs10742834 chr11:48169717 G/A cg03929089 chr4:120376271 NA -0.65 -7.03 -0.4 1.7e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg18301423 chr5:131593218 PDLIM4 0.38 5.5 0.32 8.83e-8 Acylcarnitine levels; CESC cis rs2243480 1.000 rs35396113 chr7:65495461 C/T cg13147721 chr7:65941812 NA -0.9 -8.73 -0.47 2.9e-16 Diabetic kidney disease; CESC cis rs3796352 1.000 rs13072457 chr3:53102389 G/A cg07884673 chr3:53033167 SFMBT1 0.67 5.67 0.33 3.66e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs1499972 0.590 rs62264770 chr3:117645883 C/T cg07612923 chr3:117604196 NA 0.69 6.15 0.35 2.83e-9 Schizophrenia; CESC cis rs7301826 1.000 rs7301826 chr12:131291101 C/T cg11011512 chr12:131303247 STX2 0.4 5.05 0.3 8.11e-7 Plasma plasminogen activator levels; CESC trans rs2537594 0.936 rs1404418 chr7:17814085 A/T cg18737971 chr15:43941642 CATSPER2 0.49 6.63 0.38 1.86e-10 Mean corpuscular hemoglobin; CESC cis rs7666738 0.830 rs2114426 chr4:98933130 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs208520 1.000 rs9453663 chr6:66976077 A/G cg07460842 chr6:66804631 NA 0.74 8.71 0.47 3.42e-16 Exhaled nitric oxide output; CESC cis rs709400 1.000 rs7150141 chr14:104129352 G/A cg24130564 chr14:104152367 KLC1 -0.44 -5.77 -0.33 2.26e-8 Body mass index; CESC cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg09796270 chr17:17721594 SREBF1 0.39 5.35 0.31 1.89e-7 Total body bone mineral density; CESC cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg27398817 chr8:82754497 SNX16 -0.53 -6.3 -0.36 1.24e-9 Diastolic blood pressure; CESC cis rs4588572 0.644 rs11742212 chr5:77779033 G/A cg11547950 chr5:77652471 NA -0.42 -5.77 -0.33 2.21e-8 Triglycerides; CESC cis rs2635047 1.000 rs2684818 chr18:44712965 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 7.09 0.4 1.23e-11 Educational attainment; CESC cis rs9790314 1.000 rs336589 chr3:161080358 C/T cg04691961 chr3:161091175 C3orf57 -0.42 -5.42 -0.32 1.33e-7 Morning vs. evening chronotype; CESC cis rs2415984 0.562 rs12895104 chr14:46972736 G/A cg14871534 chr14:47121158 RPL10L 0.4 5.59 0.32 5.71e-8 Number of children ever born; CESC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg00166722 chr3:10149974 C3orf24 0.49 5.98 0.34 7.37e-9 Alzheimer's disease; CESC cis rs8180040 0.764 rs11718795 chr3:47218727 G/A cg27129171 chr3:47204927 SETD2 0.69 10.44 0.54 1.33e-21 Colorectal cancer; CESC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.25e-30 Prudent dietary pattern; CESC cis rs12586317 0.547 rs10142667 chr14:35445090 A/G cg05294307 chr14:35346193 BAZ1A -0.48 -5.44 -0.32 1.21e-7 Psoriasis; CESC cis rs910316 0.935 rs175076 chr14:75505486 A/G cg08847533 chr14:75593920 NEK9 -0.95 -17.1 -0.72 1.09e-44 Height; CESC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg18252515 chr7:66147081 NA -0.46 -6.05 -0.35 5e-9 Aortic root size; CESC cis rs7432375 0.580 rs4678441 chr3:136532828 T/C cg15507776 chr3:136538369 TMEM22 0.61 7.9 0.44 7.49e-14 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26105702 chr2:209120195 IDH1 0.64 7.35 0.41 2.51e-12 Gut microbiome composition (summer); CESC cis rs765787 0.530 rs28897155 chr15:45533974 T/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.12 -0.4 9.93e-12 Uric acid levels; CESC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20284698 chr3:48956327 C3orf71;ARIH2 0.59 6.89 0.39 4.01e-11 Gut microbiome composition (summer); CESC cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.11 0.3 6.22e-7 Hip circumference adjusted for BMI; CESC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg08736216 chr1:53307985 ZYG11A -0.41 -6.91 -0.39 3.5e-11 Monocyte count; CESC cis rs4474465 0.850 rs10793324 chr11:78251485 C/T cg27205649 chr11:78285834 NARS2 -0.45 -5.53 -0.32 7.72e-8 Alzheimer's disease (survival time); CESC cis rs7561273 0.586 rs6545264 chr2:24310105 A/G cg06627628 chr2:24431161 ITSN2 -0.46 -5.48 -0.32 9.77e-8 Quantitative traits; CESC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg17724175 chr1:150552817 MCL1 0.4 6.1 0.35 3.65e-9 Melanoma; CESC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg03452623 chr4:187889614 NA -0.86 -14.74 -0.67 2.46e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg25174290 chr11:3078921 CARS 0.56 7.57 0.42 6.35e-13 Longevity; CESC cis rs10751667 0.666 rs11246358 chr11:967349 G/A cg20946044 chr11:1010712 AP2A2 -0.42 -5.74 -0.33 2.6e-8 Alzheimer's disease (late onset); CESC cis rs9788682 0.747 rs2568488 chr15:78736593 T/A cg24631222 chr15:78858424 CHRNA5 -0.64 -7.61 -0.42 4.83e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs9488822 0.597 rs12214881 chr6:116342187 G/T cg18764771 chr6:116381957 FRK 0.22 5.44 0.32 1.23e-7 Cholesterol, total;LDL cholesterol; CESC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg08888203 chr3:10149979 C3orf24 0.47 6.14 0.35 3.07e-9 Alzheimer's disease; CESC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg05313129 chr8:58192883 C8orf71 -0.53 -5.49 -0.32 9.43e-8 Developmental language disorder (linguistic errors); CESC cis rs7264396 0.690 rs17093156 chr20:34438583 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.51 -0.58 3.81e-25 Total cholesterol levels; CESC cis rs11792861 0.926 rs1333344 chr9:111776224 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 6.52 0.37 3.53e-10 Menarche (age at onset); CESC cis rs854765 0.520 rs7219324 chr17:17909775 C/T cg16928487 chr17:17741425 SREBF1 0.45 7.31 0.41 3.13e-12 Total body bone mineral density; CESC cis rs1018697 0.518 rs2250301 chr10:104548393 G/A cg04362960 chr10:104952993 NT5C2 -0.57 -6.33 -0.36 1.01e-9 Colorectal adenoma (advanced); CESC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg08109568 chr15:31115862 NA 0.73 10.07 0.53 2.13e-20 Huntington's disease progression; CESC cis rs1355223 0.867 rs1869360 chr11:34698590 C/T cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.1 -0.35 3.83e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7618501 0.521 rs3796386 chr3:49899795 G/A cg24110177 chr3:50126178 RBM5 -0.53 -7.16 -0.4 8.05e-12 Intelligence (multi-trait analysis); CESC cis rs8060686 0.641 rs3785109 chr16:68118311 G/A cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 4.92e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.54 0.64 4.19e-32 Prudent dietary pattern; CESC cis rs28374715 0.783 rs11630656 chr15:41570909 T/G cg02330683 chr15:41787940 ITPKA 0.45 5.38 0.31 1.67e-7 Ulcerative colitis; CESC cis rs12050794 0.671 rs2052713 chr15:72520392 G/C cg16672083 chr15:72433130 SENP8 0.47 7.03 0.4 1.79e-11 Metabolite levels (HVA/MHPG ratio); CESC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.81 0.39 6.64e-11 Bipolar disorder; CESC cis rs10870270 0.913 rs4550 chr10:133781798 C/T cg26149184 chr10:133730230 NA 0.38 5.14 0.3 5.32e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg16680214 chr1:154839983 KCNN3 -0.45 -6.88 -0.39 4.23e-11 Prostate cancer; CESC trans rs7977237 0.556 rs7960952 chr12:43926132 C/T cg12022049 chr14:65570008 MAX 0.5 6.22 0.36 1.91e-9 Intraocular pressure; CESC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg23161317 chr6:28129485 ZNF389 0.47 5.89 0.34 1.18e-8 Parkinson's disease; CESC cis rs2204008 0.775 rs8186812 chr12:38305055 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.87 0.52 9.34e-20 Bladder cancer; CESC cis rs7523050 0.643 rs34096625 chr1:109401101 G/A cg08274380 chr1:109419600 GPSM2 0.86 5.69 0.33 3.36e-8 Fat distribution (HIV); CESC cis rs7980687 0.527 rs1626703 chr12:123710835 A/C cg00376283 chr12:123451042 ABCB9 0.73 9.95 0.52 5.21e-20 Height;Educational attainment;Head circumference (infant); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02798621 chr6:82462430 FAM46A 0.43 6.01 0.35 6.28e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2573652 0.722 rs11630930 chr15:100544145 G/T cg00587665 chr15:100533223 ADAMTS17 -0.43 -6.94 -0.39 3e-11 Height; CESC cis rs703842 0.616 rs870392 chr12:58219173 C/A cg00677455 chr12:58241039 CTDSP2 0.74 9.95 0.52 4.9e-20 Multiple sclerosis; CESC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12142240 0.698 rs17361833 chr1:46828700 A/G cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.12e-9 Menopause (age at onset); CESC cis rs1348850 0.668 rs13010396 chr2:178492934 T/C cg22681709 chr2:178499509 PDE11A -0.49 -7.1 -0.4 1.15e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9811920 0.965 rs9837131 chr3:99854514 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.42 5.46 0.32 1.07e-7 Axial length; CESC cis rs6921919 0.583 rs2041230 chr6:28365515 A/G cg21251018 chr6:28226885 NKAPL 0.32 5.47 0.32 1.06e-7 Autism spectrum disorder or schizophrenia; CESC cis rs11252926 0.583 rs2066317 chr10:520309 C/T cg16386425 chr10:429943 DIP2C -0.47 -5.98 -0.35 7.02e-9 Psychosis in Alzheimer's disease; CESC cis rs2180341 1.000 rs6569479 chr6:127606588 A/G cg27446573 chr6:127587934 RNF146 1.07 15.97 0.7 1.09e-40 Breast cancer; CESC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg18301423 chr5:131593218 PDLIM4 0.39 5.47 0.32 1.03e-7 Acylcarnitine levels; CESC trans rs11039798 0.764 rs76882342 chr11:48939091 A/T cg15704280 chr7:45808275 SEPT13 0.69 6.44 0.37 5.66e-10 Axial length; CESC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg25072359 chr17:41440525 NA 0.52 7.68 0.43 3.18e-13 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10511669 chr16:68271177 ESRP2 0.66 7.46 0.42 1.24e-12 Gut microbiome composition (summer); CESC cis rs7829975 0.774 rs13259216 chr8:8673601 A/C cg15556689 chr8:8085844 FLJ10661 0.47 6.0 0.35 6.42e-9 Mood instability; CESC cis rs6582630 0.502 rs11614397 chr12:38328163 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.82 0.55 7.48e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg23161317 chr6:28129485 ZNF389 0.51 6.63 0.38 1.85e-10 Depression; CESC cis rs3733585 0.673 rs9994266 chr4:9954450 C/T cg00071950 chr4:10020882 SLC2A9 -0.7 -11.57 -0.58 2.45e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg26597838 chr10:835615 NA 0.72 8.29 0.45 5.56e-15 Eosinophil percentage of granulocytes; CESC cis rs4268898 0.552 rs35331966 chr2:24367828 C/T cg20701182 chr2:24300061 SF3B14 -0.39 -5.46 -0.32 1.07e-7 Asthma; CESC cis rs595982 0.702 rs638050 chr19:49375676 A/G cg03707168 chr19:49379127 PPP1R15A 0.32 5.1 0.3 6.54e-7 Red cell distribution width; CESC cis rs11658309 1 rs11658309 chr17:17762247 T/G cg16928487 chr17:17741425 SREBF1 0.59 10.67 0.55 2.43e-22 Strep throat; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16663073 chr1:2240324 SKI 0.47 6.46 0.37 5.05e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20308189 chr12:122261415 SETD1B -0.55 -6.0 -0.35 6.28e-9 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07881228 chr7:30068068 PLEKHA8 -0.45 -6.03 -0.35 5.63e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22826239 chr7:23510123 IGF2BP3 -0.52 -6.02 -0.35 5.87e-9 Gut microbiome composition (summer); CESC cis rs9911578 1.000 rs304292 chr17:56824123 G/A cg12560992 chr17:57184187 TRIM37 0.92 15.09 0.68 1.43e-37 Intelligence (multi-trait analysis); CESC cis rs5769765 0.865 rs4824108 chr22:50271428 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg08888203 chr3:10149979 C3orf24 0.51 6.33 0.36 1.02e-9 Alzheimer's disease; CESC cis rs12464559 0.522 rs4664498 chr2:152575417 A/G cg01189475 chr2:152685088 ARL5A 0.58 5.28 0.31 2.72e-7 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs2011503 1.000 rs756999 chr19:19448200 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.51 -5.13 -0.3 5.64e-7 Bipolar disorder; CESC trans rs8099014 0.911 rs4940702 chr18:56110620 T/C cg06677321 chr17:67603831 NA 0.43 6.04 0.35 5.3300000000000004e-09 Platelet count; CESC cis rs34779708 0.931 rs2384289 chr10:35343525 G/A cg04310649 chr10:35416472 CREM -0.54 -6.44 -0.37 5.73e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs713587 0.713 rs12618252 chr2:25207950 G/A cg01884057 chr2:25150051 NA -0.38 -7.14 -0.4 9.11e-12 Body mass index in non-asthmatics; CESC cis rs9611565 0.694 rs202665 chr22:41814401 A/G cg17376030 chr22:41985996 PMM1 -0.62 -6.64 -0.38 1.79e-10 Vitiligo; CESC trans rs6600671 0.934 rs12060031 chr1:121243450 A/G cg17023122 chr1:144479586 NA -0.46 -6.14 -0.35 3.04e-9 Hip geometry; CESC cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg05283184 chr6:79620031 NA -0.43 -6.65 -0.38 1.68e-10 Intelligence (multi-trait analysis); CESC cis rs826838 1.000 rs1719848 chr12:39085586 A/G cg26384229 chr12:38710491 ALG10B -0.62 -9.95 -0.52 5e-20 Heart rate; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00547444 chr16:2587590 PDPK1 -0.46 -6.06 -0.35 4.56e-9 Asthma; CESC cis rs763121 0.853 rs2072795 chr22:39064209 A/G cg21395723 chr22:39101663 GTPBP1 -0.43 -5.51 -0.32 8.4e-8 Menopause (age at onset); CESC cis rs34172651 0.876 rs2112785 chr16:24781176 C/T cg06028605 chr16:24865363 SLC5A11 0.35 5.5 0.32 8.72e-8 Intelligence (multi-trait analysis); CESC cis rs506597 0.920 rs221778 chr7:100298024 A/G cg10426581 chr7:100472382 SRRT -0.67 -5.16 -0.3 4.81e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg18876405 chr7:65276391 NA 0.49 6.55 0.37 3e-10 Aortic root size; CESC cis rs2625529 0.730 rs2929527 chr15:72282270 T/G cg16672083 chr15:72433130 SENP8 0.41 6.32 0.36 1.1e-9 Red blood cell count; CESC trans rs9467711 0.606 rs2393667 chr6:26421345 T/C cg06606381 chr12:133084897 FBRSL1 -0.82 -6.98 -0.39 2.4e-11 Autism spectrum disorder or schizophrenia; CESC cis rs7932354 0.666 rs6485696 chr11:46842045 C/T cg25783544 chr11:47291846 MADD -0.39 -5.1 -0.3 6.39e-7 Bone mineral density (hip);Bone mineral density; CESC cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg05347473 chr6:146136440 FBXO30 0.58 7.38 0.41 2.1e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6582630 0.576 rs11504369 chr12:38274566 C/T cg26384229 chr12:38710491 ALG10B -0.43 -5.77 -0.33 2.22e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs2732480 0.577 rs1489108 chr12:48738781 G/A cg24011408 chr12:48396354 COL2A1 0.44 5.99 0.35 6.63e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs6831352 0.725 rs2602846 chr4:100025151 T/A cg12011299 chr4:100065546 ADH4 0.6 6.6 0.38 2.23e-10 Alcohol dependence; CESC cis rs7605827 0.897 rs6431697 chr2:15540034 G/C cg19274914 chr2:15703543 NA 0.34 6.12 0.35 3.44e-9 Educational attainment (years of education); CESC cis rs9910055 0.529 rs575798 chr17:42181796 A/C cg08499158 chr17:42289980 UBTF 0.43 5.13 0.3 5.72e-7 Total body bone mineral density; CESC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg12463550 chr7:65579703 CRCP 0.56 6.94 0.39 3.07e-11 Aortic root size; CESC cis rs9457247 0.565 rs55873403 chr6:167511800 C/T cg07741184 chr6:167504864 NA 0.43 7.69 0.43 2.96e-13 Crohn's disease; CESC cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg21573476 chr21:45109991 RRP1B -0.41 -5.8 -0.34 1.85e-8 Mean corpuscular volume; CESC cis rs10848704 0.525 rs4765709 chr12:2883637 C/T cg19995117 chr12:2880862 NA 0.5 7.77 0.43 1.77e-13 Quantitative traits; CESC cis rs6460942 1.000 rs2053378 chr7:12405564 C/G cg02935154 chr7:12443704 VWDE -0.57 -5.8 -0.34 1.89e-8 Coronary artery disease; CESC cis rs2262909 0.962 rs55735642 chr19:22241176 C/T cg11619707 chr19:22235551 ZNF257 0.33 5.17 0.3 4.65e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs951366 0.677 rs1775140 chr1:205672107 C/A cg23034840 chr1:205782522 SLC41A1 0.6 6.8 0.39 7.03e-11 Menarche (age at onset); CESC cis rs12142240 0.659 rs67547686 chr1:46832229 G/C cg00530320 chr1:46809349 NSUN4 0.6 8.08 0.44 2.37e-14 Menopause (age at onset); CESC cis rs897080 0.515 rs698815 chr2:44706974 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.52 0.32 8.26e-8 Height; CESC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg26314531 chr2:26401878 FAM59B -0.77 -8.58 -0.47 7.92e-16 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09664812 chr18:9475361 RALBP1 0.42 6.4 0.37 7.19e-10 Gambling; CESC cis rs2243480 1.000 rs2462569 chr7:65474846 C/T cg13147721 chr7:65941812 NA 0.84 8.29 0.45 5.55e-15 Diabetic kidney disease; CESC cis rs2354432 0.607 rs10900350 chr1:146828017 T/G cg25205988 chr1:146714368 CHD1L 0.99 9.12 0.49 1.88e-17 Mitochondrial DNA levels; CESC cis rs7824557 0.713 rs6601575 chr8:11097804 A/C cg21775007 chr8:11205619 TDH 0.41 6.12 0.35 3.35e-9 Retinal vascular caliber; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23009962 chr19:18572435 ELL 0.49 6.64 0.38 1.76e-10 Fibrinogen levels; CESC cis rs4308124 0.708 rs6749633 chr2:111988016 A/G cg04571233 chr2:111982156 NA 0.61 6.81 0.39 6.43e-11 Vitiligo; CESC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg11890956 chr21:40555474 PSMG1 1.14 18.57 0.75 7.34e-50 Cognitive function; CESC cis rs4906332 1.000 rs3783400 chr14:103967045 G/A cg09975044 chr14:104007538 NA 0.48 6.37 0.36 8.11e-10 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05290695 chr8:119634602 SAMD12 -0.43 -6.1 -0.35 3.82e-9 Gut microbiota (bacterial taxa); CESC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg27170947 chr2:26402098 FAM59B -0.59 -7.07 -0.4 1.36e-11 Gut microbiome composition (summer); CESC cis rs941408 1.000 rs1640271 chr19:2799979 C/T cg00079169 chr19:2811669 THOP1 0.47 6.98 0.39 2.42e-11 Total cholesterol levels; CESC cis rs2204008 0.744 rs11514073 chr12:38399553 A/C cg13010199 chr12:38710504 ALG10B 0.52 6.5 0.37 4.01e-10 Bladder cancer; CESC trans rs561341 0.710 rs9900031 chr17:30199537 T/C cg20587970 chr11:113659929 NA 0.82 9.2 0.49 1.07e-17 Hip circumference adjusted for BMI; CESC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg18758796 chr5:131593413 PDLIM4 -0.47 -6.32 -0.36 1.12e-9 Acylcarnitine levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07254608 chr8:41997973 NA 0.49 6.58 0.37 2.55e-10 Systemic lupus erythematosus; CESC trans rs76096589 0.557 rs78173809 chr14:51145578 C/G cg04353483 chr4:26493496 CCKAR 0.8 5.99 0.35 6.7e-9 Diisocyanate-induced asthma; CESC cis rs963731 0.579 rs3796038 chr2:39239572 G/C cg04010122 chr2:39346883 SOS1 -0.6 -5.43 -0.32 1.26e-7 Corticobasal degeneration; CESC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg02569458 chr12:86230093 RASSF9 -0.46 -7.15 -0.4 8.28e-12 Major depressive disorder; CESC cis rs9902453 0.765 rs3115087 chr17:28030267 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 9.06 0.49 2.98e-17 Coffee consumption (cups per day); CESC cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg11752832 chr7:134001865 SLC35B4 0.52 6.77 0.38 8.12e-11 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13921000 chr7:54827064 SEC61G 0.58 6.54 0.37 3.22e-10 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06592170 chr5:57755298 PLK2 -0.38 -6.02 -0.35 5.8e-9 Gambling; CESC cis rs6500395 1.000 rs2883475 chr16:48560315 C/T cg04672837 chr16:48644449 N4BP1 0.46 5.3 0.31 2.42e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg07636037 chr3:49044803 WDR6 1.05 18.71 0.75 2.31e-50 Parkinson's disease; CESC cis rs208520 1.000 rs208527 chr6:66957209 A/C cg07460842 chr6:66804631 NA -0.9 -10.34 -0.54 2.79e-21 Exhaled nitric oxide output; CESC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.48 6.96 0.39 2.63e-11 Menopause (age at onset); CESC cis rs7607369 0.719 rs690882 chr2:219640620 T/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.74 -0.38 9.72e-11 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs2645694 0.626 rs2645684 chr4:77819892 A/C cg10057126 chr4:77819792 ANKRD56 0.59 8.66 0.47 4.84e-16 Emphysema distribution in smoking; CESC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs10504229 1.000 rs57378064 chr8:58169844 C/G cg05313129 chr8:58192883 C8orf71 -0.45 -5.51 -0.32 8.3e-8 Developmental language disorder (linguistic errors); CESC cis rs7580658 0.724 rs4662711 chr2:127990840 G/A cg10021288 chr2:128175891 PROC -0.39 -6.14 -0.35 3.05e-9 Protein C levels; CESC cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg16339924 chr4:17578868 LAP3 0.59 7.4 0.41 1.83e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07905888 chr1:36023245 NCDN;KIAA0319L 0.59 6.85 0.39 5.12e-11 Gut microbiome composition (summer); CESC cis rs9894429 0.646 rs8080391 chr17:79566319 A/T cg21984481 chr17:79567631 NPLOC4 0.57 9.34 0.5 4e-18 Eye color traits; CESC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg24250549 chr1:154909240 PMVK 0.62 8.69 0.47 3.86e-16 Prostate cancer; CESC cis rs9858542 0.537 rs4410472 chr3:49329090 A/T cg00383909 chr3:49044727 WDR6 0.55 5.49 0.32 9.33e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4298948 0.590 rs11043250 chr12:122372815 A/C cg01765077 chr12:122356316 WDR66 0.49 5.14 0.3 5.43e-7 Obesity-related traits; CESC cis rs7917772 0.503 rs7078435 chr10:104304766 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.07 0.3 7.42e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg04317338 chr11:64019027 PLCB3 0.87 9.06 0.49 3.04e-17 Mean platelet volume; CESC cis rs9581857 0.579 rs3759433 chr13:27997999 C/T cg22138327 chr13:27999177 GTF3A 0.76 8.48 0.46 1.58e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs1874326 0.545 rs2353348 chr7:138111275 T/C cg18008034 chr7:138118925 NA -0.41 -5.12 -0.3 5.89e-7 Quantitative traits; CESC cis rs17826219 0.706 rs61643715 chr17:29057762 A/G cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Body mass index; CESC cis rs1506636 0.646 rs805778 chr7:123214655 C/T cg03229431 chr7:123269106 ASB15 -0.39 -5.24 -0.31 3.21e-7 Plateletcrit;Platelet count; CESC cis rs11098499 0.954 rs28572238 chr4:120316686 T/G cg24375607 chr4:120327624 NA 0.47 5.62 0.33 4.74e-8 Corneal astigmatism; CESC cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg08885076 chr2:99613938 TSGA10 -0.37 -5.04 -0.3 8.69e-7 Chronic sinus infection; CESC trans rs10411161 0.640 rs7252303 chr19:52389357 G/A cg22319618 chr22:45562946 NUP50 -0.75 -7.55 -0.42 7.24e-13 Breast cancer; CESC cis rs1538970 0.781 rs713358 chr1:45988267 C/G cg05343316 chr1:45956843 TESK2 0.87 11.83 0.59 3.22e-26 Platelet count; CESC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg17911788 chr17:44343683 NA -0.44 -6.73 -0.38 1.03e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.75 0.47 2.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9859260 0.744 rs492349 chr3:195784192 G/A cg12923728 chr3:195709715 SDHAP1 0.54 6.96 0.39 2.68e-11 Mean corpuscular volume; CESC cis rs7833986 0.501 rs2719257 chr8:56940173 A/G cg26371346 chr8:56986568 SNORD54;RPS20 0.56 5.12 0.3 5.87e-7 Height; CESC cis rs477692 0.544 rs7894836 chr10:131442595 T/A cg24747557 chr10:131355152 MGMT 0.47 6.5 0.37 4.03e-10 Response to temozolomide; CESC trans rs7943203 0.962 rs116201292 chr11:108313599 T/C cg24643211 chr18:11851603 GNAL;CHMP1B -0.48 -6.14 -0.35 3.01e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs2204008 0.627 rs10878486 chr12:38148601 T/G cg13010199 chr12:38710504 ALG10B 0.54 6.67 0.38 1.48e-10 Bladder cancer; CESC cis rs10851478 0.872 rs12232355 chr15:49832378 C/T cg08060515 chr15:49448048 GALK2;COPS2 0.41 5.05 0.3 8.06e-7 Oral cavity cancer; CESC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg05564831 chr3:52568323 NT5DC2 0.48 7.6 0.42 5.08e-13 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26342398 chr1:85156326 SSX2IP 0.62 7.34 0.41 2.59e-12 Gut microbiome composition (summer); CESC cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg22875332 chr1:76189707 ACADM 0.63 6.94 0.39 3.02e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg22590775 chr19:49891494 CCDC155 0.43 5.12 0.3 5.77e-7 Multiple sclerosis; CESC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg23281280 chr6:28129359 ZNF389 0.5 6.56 0.37 2.75e-10 Parkinson's disease; CESC cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg20476274 chr7:133979776 SLC35B4 0.67 9.79 0.52 1.65e-19 Mean platelet volume; CESC cis rs933688 1.000 rs6452953 chr5:90723034 T/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.08 13.54 0.64 4.18e-32 Smoking behavior; CESC cis rs9354308 0.933 rs2022856 chr6:66568235 G/T cg07460842 chr6:66804631 NA 0.68 7.68 0.43 3.08e-13 Metabolite levels; CESC trans rs11098499 0.780 rs12504773 chr4:120562149 G/C cg25214090 chr10:38739885 LOC399744 0.68 9.41 0.5 2.57e-18 Corneal astigmatism; CESC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg14024328 chr4:719362 PCGF3 -0.66 -9.47 -0.5 1.59e-18 White blood cell count; CESC cis rs3768617 0.510 rs12086466 chr1:183075778 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.83 -13.15 -0.63 9.69e-31 Fuchs's corneal dystrophy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.15.979660F chr15:65855109 PTPLAD1 0.45 6.17 0.35 2.59e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16333535 chr22:24093440 ZNF70 -0.48 -6.88 -0.39 4.25e-11 Gambling; CESC cis rs11249608 0.548 rs7709054 chr5:178462757 C/T cg21905437 chr5:178450457 ZNF879 0.58 8.14 0.45 1.56e-14 Pubertal anthropometrics; CESC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg04772025 chr11:68637568 NA 0.5 6.06 0.35 4.78e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.71 0.62 3.31e-29 Gut microbiome composition (summer); CESC cis rs7662987 0.517 rs2851256 chr4:100039549 G/A cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC cis rs1475911 0.708 rs8129075 chr21:43523430 G/T cg09849774 chr21:43526787 UMODL1;C21orf128 -0.42 -5.13 -0.3 5.53e-7 IgG glycosylation; CESC cis rs72781680 1.000 rs61739076 chr2:24149439 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.73 0.38 1.07e-10 Lymphocyte counts; CESC cis rs921968 0.643 rs589967 chr2:219445165 T/C cg02176678 chr2:219576539 TTLL4 0.42 7.28 0.41 3.73e-12 Mean corpuscular hemoglobin concentration; CESC trans rs1973993 0.689 rs17131755 chr1:96886167 G/A cg10631902 chr5:14652156 NA -0.49 -6.39 -0.37 7.58e-10 Weight; CESC trans rs208520 0.690 rs851464 chr6:66839802 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -13.08 -0.63 1.69e-30 Exhaled nitric oxide output; CESC cis rs6736093 0.966 rs11685190 chr2:112748704 T/C cg12686935 chr2:112915763 FBLN7 -0.42 -5.45 -0.32 1.17e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22825979 chr13:50571203 TRIM13;DLEU2 0.61 7.31 0.41 3.21e-12 Gut microbiome composition (summer); CESC cis rs6540556 0.954 rs611861 chr1:209937251 C/G cg05527609 chr1:210001259 C1orf107 -0.5 -6.55 -0.37 2.94e-10 Red blood cell count; CESC cis rs17376456 1.000 rs12187701 chr5:93522290 A/G cg25358565 chr5:93447407 FAM172A 1.18 11.23 0.57 3.38e-24 Diabetic retinopathy; CESC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg17376030 chr22:41985996 PMM1 -0.61 -6.41 -0.37 6.79e-10 Vitiligo; CESC cis rs2204008 0.774 rs12810027 chr12:38212165 A/G cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs5769765 0.955 rs61136468 chr22:50312679 A/G cg26441486 chr22:50317300 CRELD2 0.39 5.32 0.31 2.23e-7 Schizophrenia; CESC cis rs2011503 0.882 rs1064395 chr19:19361735 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.58 0.32 6.04e-8 Bipolar disorder; CESC cis rs1707322 0.721 rs28641748 chr1:46212836 A/G cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg11987759 chr7:65425863 GUSB -0.46 -6.06 -0.35 4.61e-9 Aortic root size; CESC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg03352830 chr11:487213 PTDSS2 0.74 7.21 0.4 5.99e-12 Body mass index; CESC cis rs2733201 1.000 rs2706472 chr15:44433292 T/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -5.29 -0.31 2.59e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg09509183 chr1:209979624 IRF6 0.5 6.35 0.36 9.56e-10 Cleft lip with or without cleft palate; CESC cis rs9393777 0.623 rs9366658 chr6:26469866 G/A cg14345882 chr6:26364793 BTN3A2 0.43 5.39 0.31 1.54e-7 Intelligence (multi-trait analysis); CESC cis rs9790314 1.000 rs4370045 chr3:160943865 A/G cg03342759 chr3:160939853 NMD3 -0.52 -6.84 -0.39 5.32e-11 Morning vs. evening chronotype; CESC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg24829409 chr8:58192753 C8orf71 -0.74 -8.62 -0.47 6.24e-16 Developmental language disorder (linguistic errors); CESC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.34 0.31 1.99e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11528995 chr1:117210575 IGSF3 0.57 6.82 0.39 6.21e-11 Gut microbiome composition (summer); CESC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg17971929 chr21:40555470 PSMG1 -0.55 -7.22 -0.41 5.4e-12 Menarche (age at onset); CESC cis rs8014204 0.806 rs11159105 chr14:75298052 C/T cg08847533 chr14:75593920 NEK9 0.47 6.01 0.35 6.18e-9 Caffeine consumption; CESC cis rs6500395 0.962 rs7199625 chr16:48650217 G/C cg04672837 chr16:48644449 N4BP1 0.47 5.57 0.32 6.4e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg12648201 chr2:27665141 KRTCAP3 -0.31 -5.63 -0.33 4.6e-8 Total body bone mineral density; CESC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg18225595 chr11:63971243 STIP1 0.53 5.57 0.32 6.17e-8 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24826392 chr2:73964445 TPRKB 0.64 7.64 0.42 3.88e-13 Gut microbiome composition (summer); CESC cis rs7107174 1.000 rs1017908 chr11:77948095 A/G cg02023728 chr11:77925099 USP35 0.56 7.06 0.4 1.43e-11 Testicular germ cell tumor; CESC cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg20503657 chr10:835505 NA 1.06 9.85 0.52 1.07e-19 Eosinophil percentage of granulocytes; CESC cis rs4919694 1.000 rs17727044 chr10:104821256 A/T cg04362960 chr10:104952993 NT5C2 0.77 6.13 0.35 3.21e-9 Arsenic metabolism; CESC cis rs1775715 0.737 rs12256714 chr10:32216262 A/G cg26784012 chr10:32216390 ARHGAP12 -0.38 -5.09 -0.3 6.76e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9467711 0.659 rs3734542 chr6:26468326 G/A cg14345882 chr6:26364793 BTN3A2 0.62 5.49 0.32 9.43e-8 Autism spectrum disorder or schizophrenia; CESC cis rs8040855 0.627 rs1532776 chr15:85624614 C/T cg08123816 chr15:85640762 PDE8A -0.39 -5.8 -0.34 1.85e-8 Bulimia nervosa; CESC cis rs17209837 1.000 rs2302386 chr7:87091944 A/G cg00919237 chr7:87102261 ABCB4 -0.53 -6.03 -0.35 5.36e-9 Gallbladder cancer; CESC cis rs9814567 1.000 rs1814336 chr3:134200823 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.34 -0.36 9.66e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21236379 chr12:132328596 MMP17 0.42 6.17 0.35 2.51e-9 Fibrinogen levels; CESC cis rs904092 0.720 rs1229977 chr4:100202414 A/G cg12011299 chr4:100065546 ADH4 -0.54 -6.19 -0.36 2.28e-9 Alcohol dependence; CESC cis rs4253772 0.591 rs6008384 chr22:46655948 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.14 0.45 1.54e-14 LDL cholesterol;Cholesterol, total; CESC cis rs6582630 0.519 rs11181526 chr12:38360230 A/G cg26384229 chr12:38710491 ALG10B 0.69 10.42 0.54 1.6e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.03 -0.35 5.59e-9 Total body bone mineral density; CESC cis rs1348850 0.872 rs13004955 chr2:178398923 A/T cg22681709 chr2:178499509 PDE11A 0.41 5.68 0.33 3.63e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs17376456 0.877 rs9314101 chr5:93461593 A/T cg25358565 chr5:93447407 FAM172A 1.15 11.8 0.59 4.11e-26 Diabetic retinopathy; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00650762 chr1:23037368 EPHB2 -0.51 -7.11 -0.4 1.1e-11 Asthma; CESC cis rs7107174 1.000 rs2510035 chr11:77953175 A/C cg02023728 chr11:77925099 USP35 0.52 6.78 0.38 7.87e-11 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01813761 chr14:20812041 PARP2;RPPH1 -0.58 -6.6 -0.38 2.23e-10 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg25927219 chr12:112123710 ACAD10;BRAP -0.5 -6.22 -0.36 1.91e-9 Asthma; CESC cis rs3806843 1.000 rs3822346 chr5:140187322 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.26 -0.31 2.95e-7 Depressive symptoms (multi-trait analysis); CESC cis rs459571 0.920 rs455073 chr9:136909141 G/C cg13789015 chr9:136890014 NCRNA00094 0.56 8.07 0.44 2.54e-14 Platelet distribution width; CESC cis rs2070488 0.775 rs7374458 chr3:38531211 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 13.35 0.63 1.93e-31 Electrocardiographic conduction measures; CESC cis rs12477438 0.765 rs62156363 chr2:99693324 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs2295359 1.000 rs12043240 chr1:67624304 C/T cg03340356 chr1:67600835 NA 0.33 5.42 0.32 1.37e-7 Psoriasis; CESC cis rs9916302 0.706 rs1877030 chr17:37740161 T/C cg07936489 chr17:37558343 FBXL20 -0.96 -9.84 -0.52 1.12e-19 Glomerular filtration rate (creatinine); CESC cis rs116095464 0.558 rs7356561 chr5:284381 G/C cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.77e-15 Breast cancer; CESC cis rs4253772 0.530 rs6008662 chr22:46713917 G/A cg09491104 chr22:46646882 C22orf40 -0.58 -8.42 -0.46 2.37e-15 LDL cholesterol;Cholesterol, total; CESC cis rs7259376 0.875 rs2116919 chr19:22491706 C/G cg02657401 chr19:22469223 NA -0.27 -5.41 -0.32 1.44e-7 Menopause (age at onset); CESC cis rs2637266 0.935 rs2583049 chr10:78403962 T/C cg18941641 chr10:78392320 NA 0.45 8.65 0.47 4.9e-16 Pulmonary function; CESC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg05872129 chr22:39784769 NA -0.77 -9.75 -0.51 2.13e-19 Intelligence (multi-trait analysis); CESC cis rs10256972 0.528 rs7784607 chr7:1178694 A/G cg15112475 chr7:1198522 ZFAND2A -0.38 -6.02 -0.35 5.95e-9 Longevity;Endometriosis; CESC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs28374715 0.662 rs8038983 chr15:41473316 G/A cg18705301 chr15:41695430 NDUFAF1 -0.79 -10.26 -0.53 5.16e-21 Ulcerative colitis; CESC cis rs2730245 0.527 rs2709858 chr7:158675266 C/G cg24397884 chr7:158709396 WDR60 0.85 8.81 0.48 1.67e-16 Height; CESC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.71 7.66 0.43 3.47e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9796 0.689 rs6492983 chr15:41436049 T/G cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.74 -0.38 9.74e-11 Menopause (age at onset); CESC cis rs7178572 0.568 rs7175674 chr15:77670910 C/T cg22256960 chr15:77711686 NA -0.53 -6.79 -0.38 7.5e-11 Type 2 diabetes; CESC cis rs6963495 0.818 rs6956234 chr7:105149707 A/G cg02135003 chr7:105160482 PUS7 -0.47 -5.61 -0.33 5.12e-8 Bipolar disorder (body mass index interaction); CESC cis rs1729951 0.546 rs835634 chr3:136676303 C/T cg03617693 chr3:136751559 NA 0.37 5.17 0.3 4.6e-7 Neuroticism; CESC cis rs3026101 0.671 rs1806239 chr17:5295528 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs71403859 0.730 rs12923781 chr16:71653464 G/A cg08717414 chr16:71523259 ZNF19 -0.74 -6.38 -0.36 7.77e-10 Post bronchodilator FEV1; CESC cis rs854765 0.822 rs1889014 chr17:17767165 C/T cg09796270 chr17:17721594 SREBF1 -0.42 -5.76 -0.33 2.35e-8 Total body bone mineral density; CESC cis rs568617 1.000 rs693824 chr11:65654783 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.69 7.43 0.42 1.47e-12 Crohn's disease; CESC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.41e-28 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12152867 chr6:56708725 DST 0.61 6.86 0.39 4.94e-11 Gut microbiome composition (summer); CESC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg19318889 chr4:1322082 MAEA 0.47 6.04 0.35 5.1e-9 Longevity; CESC cis rs4243830 0.850 rs4908912 chr1:6599558 A/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -7.39 -0.41 1.89e-12 Body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05144345 chr4:1686368 FAM53A -0.39 -6.13 -0.35 3.2e-9 Gambling; CESC cis rs8180040 0.593 rs12715421 chr3:47084859 A/G cg27129171 chr3:47204927 SETD2 0.66 9.9 0.52 7.19e-20 Colorectal cancer; CESC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg24549020 chr5:56110836 MAP3K1 0.66 7.45 0.42 1.29e-12 Initial pursuit acceleration; CESC trans rs3780486 1.000 rs12342831 chr9:33124872 A/G cg20290983 chr6:43655470 MRPS18A 0.85 12.42 0.61 3.21e-28 IgG glycosylation; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg25934064 chr3:52569026 NT5DC2 0.27 5.56 0.32 6.56e-8 Electroencephalogram traits; CESC cis rs7666738 0.570 rs11097612 chr4:99079772 T/C cg05340658 chr4:99064831 C4orf37 0.65 9.03 0.49 3.66e-17 Colonoscopy-negative controls vs population controls; CESC cis rs12477438 0.798 rs6761570 chr2:99577276 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.51 -0.54 7.92e-22 Chronic sinus infection; CESC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg01073479 chr16:3509474 NAT15 -0.33 -5.09 -0.3 6.74e-7 Tuberculosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10800280 chr6:36646508 CDKN1A 0.53 6.19 0.36 2.27e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg05313129 chr8:58192883 C8orf71 -0.56 -6.45 -0.37 5.31e-10 Developmental language disorder (linguistic errors); CESC cis rs5753618 0.561 rs715510 chr22:31690528 T/A cg00478049 chr22:31556069 RNF185 0.44 5.03 0.3 9.11e-7 Colorectal cancer; CESC cis rs939574 1.000 rs3817424 chr2:220096903 A/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.84 7.61 0.42 4.85e-13 Platelet distribution width; CESC cis rs9291683 0.588 rs13113730 chr4:10017628 C/T cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.14e-46 Bone mineral density; CESC cis rs7772486 0.817 rs9386145 chr6:146363519 A/T cg23711669 chr6:146136114 FBXO30 0.83 12.12 0.6 3.46e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs117623576 0.887 rs211411 chr10:32394992 T/C cg03047570 chr10:32398778 NA 0.79 8.24 0.45 8.13e-15 Anti-saccade response; CESC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg18337363 chr3:52569053 NT5DC2 0.3 5.58 0.32 6.01e-8 Electroencephalogram traits; CESC cis rs17253792 0.731 rs8008528 chr14:56062052 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.62 0.33 4.81e-8 Putamen volume; CESC cis rs2243480 1.000 rs67536397 chr7:65947917 G/A cg12463550 chr7:65579703 CRCP 0.71 5.46 0.32 1.08e-7 Diabetic kidney disease; CESC cis rs2230307 0.536 rs631977 chr1:100544564 C/G cg24955406 chr1:100503596 HIAT1 0.53 5.41 0.32 1.38e-7 Carotid intima media thickness; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg01737828 chr15:75230659 COX5A 0.46 6.45 0.37 5.41e-10 Systemic lupus erythematosus; CESC cis rs7647973 0.769 rs7434187 chr3:49032967 C/T cg06212747 chr3:49208901 KLHDC8B 0.5 5.47 0.32 1.06e-7 Menarche (age at onset); CESC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg19046167 chr17:80928561 B3GNTL1 0.49 5.96 0.34 7.95e-9 Glycated hemoglobin levels; CESC cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.58 -5.1 -0.3 6.48e-7 Diabetic retinopathy; CESC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg06456125 chr7:65229604 NA -0.44 -5.77 -0.33 2.23e-8 Calcium levels; CESC cis rs6032067 0.777 rs62208385 chr20:43789823 A/T cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs72781680 1.000 rs7581107 chr2:24173565 C/T cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs7586879 0.616 rs6545809 chr2:25126715 C/T cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.02e-11 Body mass index; CESC cis rs3820928 0.874 rs13413235 chr2:227893863 C/T cg05526886 chr2:227700861 RHBDD1 -0.45 -5.72 -0.33 2.82e-8 Pulmonary function; CESC cis rs11078597 0.731 rs4790285 chr17:1651697 C/T cg18436246 chr17:1640651 WDR81 -0.58 -7.18 -0.4 7.12e-12 Serum albumin level; CESC cis rs1443512 0.755 rs1373160 chr12:54340383 A/G cg17410650 chr12:54324560 NA -0.47 -7.65 -0.43 3.85e-13 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg19901468 chr14:105411992 AHNAK2 -0.6 -8.69 -0.47 3.79e-16 Rheumatoid arthritis; CESC cis rs4604732 0.631 rs10802509 chr1:247627158 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs1814175 0.817 rs12290508 chr11:49621037 C/T cg03929089 chr4:120376271 NA -0.9 -14.83 -0.67 1.19e-36 Height; CESC cis rs4727963 0.846 rs66681308 chr7:122738236 T/G cg03640110 chr7:122635026 TAS2R16 -0.36 -5.42 -0.32 1.32e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs7243790 0.905 rs1523871 chr18:51950877 C/G cg04730925 chr18:51795821 POLI -0.41 -5.49 -0.32 9.19e-8 Diastolic blood pressure; CESC cis rs4664308 0.618 rs35771982 chr2:160885418 G/C cg03641300 chr2:160917029 PLA2R1 -0.59 -8.54 -0.46 1.07e-15 Idiopathic membranous nephropathy; CESC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg18490616 chr2:88469792 THNSL2 0.56 5.41 0.32 1.38e-7 Plasma clusterin levels; CESC cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg10691866 chr7:65817282 TPST1 -0.32 -5.17 -0.3 4.71e-7 Aortic root size; CESC cis rs1729951 0.546 rs12054408 chr3:136677645 T/C cg25687071 chr3:136751404 NA 0.39 5.17 0.3 4.65e-7 Neuroticism; CESC cis rs2732480 0.500 rs7297824 chr12:48598650 T/C cg04545296 chr12:48745243 ZNF641 0.4 6.74 0.38 9.66e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9894429 0.789 rs6565611 chr17:79598319 T/C cg21984481 chr17:79567631 NPLOC4 -0.56 -8.97 -0.48 5.52e-17 Eye color traits; CESC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg22920501 chr2:26401640 FAM59B 0.78 9.53 0.51 1.06e-18 Gut microbiome composition (summer); CESC cis rs524281 0.773 rs11227413 chr11:65883696 G/A cg14036092 chr11:66035641 RAB1B -0.62 -6.3 -0.36 1.25e-9 Electroencephalogram traits; CESC cis rs73206853 0.563 rs7960761 chr12:111164415 T/C cg12870014 chr12:110450643 ANKRD13A 0.73 5.36 0.31 1.78e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs3091242 0.728 rs706845 chr1:25730713 G/A cg27572855 chr1:25598939 RHD 0.43 7.03 0.4 1.79e-11 Erythrocyte sedimentation rate; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12148919 chr6:128841705 PTPRK 0.45 6.02 0.35 5.64e-9 Systemic lupus erythematosus; CESC cis rs11098499 0.955 rs56386062 chr4:120155135 T/C cg09307838 chr4:120376055 NA 0.87 11.39 0.57 1.02e-24 Corneal astigmatism; CESC cis rs1552244 0.882 rs13100734 chr3:10022878 A/G cg00166722 chr3:10149974 C3orf24 0.49 6.04 0.35 5.21e-9 Alzheimer's disease; CESC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg07747251 chr5:1868357 NA 0.31 5.12 0.3 5.88e-7 Cardiovascular disease risk factors; CESC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg22029157 chr1:209979665 IRF6 0.76 8.93 0.48 7.36e-17 Cleft lip with or without cleft palate; CESC cis rs8077577 0.836 rs11652964 chr17:18040404 C/T cg16794390 chr17:18148240 FLII 0.47 5.79 0.34 1.94e-8 Obesity-related traits; CESC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg11965913 chr1:205819406 PM20D1 0.83 13.73 0.64 8.9e-33 Menarche (age at onset); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10962336 chr13:48807050 ITM2B -0.48 -6.42 -0.37 6.34e-10 Asthma; CESC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs7937682 0.587 rs611607 chr11:111349765 C/T cg09085632 chr11:111637200 PPP2R1B -0.62 -8.22 -0.45 8.93e-15 Primary sclerosing cholangitis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg05310071 chr17:16120569 PIGL -0.42 -6.1 -0.35 3.67e-9 Height; CESC cis rs7527798 0.592 rs11118281 chr1:207832102 C/T cg21110645 chr1:207815933 NA -0.31 -5.41 -0.32 1.43e-7 Erythrocyte sedimentation rate; CESC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg18350739 chr11:68623251 NA -0.46 -6.81 -0.39 6.51e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Depression; CESC trans rs722599 0.748 rs55707505 chr14:75362552 T/C cg00095594 chr1:236228625 NID1 -0.4 -6.28 -0.36 1.39e-9 IgG glycosylation; CESC cis rs367943 0.556 rs7709820 chr5:112991327 G/A cg12552261 chr5:112820674 MCC 0.39 5.06 0.3 7.7e-7 Type 2 diabetes; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg19728485 chr2:11295717 PQLC3 -0.47 -6.01 -0.35 6.26e-9 Prevalent atrial fibrillation; CESC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg24829409 chr8:58192753 C8orf71 -0.67 -8.18 -0.45 1.19e-14 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg04944784 chr2:26401820 FAM59B 0.93 10.1 0.53 1.71e-20 Gut microbiome composition (summer); CESC cis rs561341 0.769 rs559228 chr17:30294527 T/C cg00745463 chr17:30367425 LRRC37B -0.81 -7.35 -0.41 2.5e-12 Hip circumference adjusted for BMI; CESC cis rs9300255 0.544 rs1716157 chr12:123670473 T/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.21 -0.36 2.01e-9 Neutrophil percentage of white cells; CESC cis rs11958404 0.932 rs72816592 chr5:157435246 A/G cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23594427 chr12:56367798 RAB5B -0.44 -6.14 -0.35 2.99e-9 Asthma; CESC cis rs2072732 0.821 rs10909868 chr1:2962207 A/C cg03976712 chr1:2946727 NA 0.32 5.6 0.33 5.4e-8 Plateletcrit; CESC cis rs7980687 0.628 rs2851443 chr12:123694250 C/T cg05973401 chr12:123451056 ABCB9 0.46 5.67 0.33 3.65e-8 Height;Educational attainment;Head circumference (infant); CESC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.64 7.43 0.42 1.47e-12 Gut microbiome composition (summer); CESC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg18230493 chr5:56204884 C5orf35 0.62 8.02 0.44 3.32e-14 Initial pursuit acceleration; CESC cis rs6714710 0.603 rs17489454 chr2:98407350 C/T cg26665480 chr2:98280029 ACTR1B 0.56 7.94 0.44 5.93e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg10596483 chr8:143751796 JRK -0.47 -5.26 -0.31 2.99e-7 Urinary tract infection frequency; CESC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg18252515 chr7:66147081 NA -0.48 -6.45 -0.37 5.25e-10 Aortic root size; CESC cis rs7208859 0.673 rs11654331 chr17:29165017 A/G cg19761014 chr17:28927070 LRRC37B2 0.63 5.24 0.31 3.23e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs4665809 1.000 rs6704930 chr2:26325705 G/A cg09258813 chr8:37823409 ADRB3 -0.37 -6.08 -0.35 4.08e-9 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg09365446 chr1:150670422 GOLPH3L 0.43 5.96 0.34 7.93e-9 Tonsillectomy; CESC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg03188948 chr7:1209495 NA 0.72 6.93 0.39 3.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4144743 1.000 rs72823473 chr17:45321775 A/T cg18085866 chr17:45331354 ITGB3 -0.64 -7.03 -0.4 1.78e-11 Body mass index; CESC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg13777783 chr17:79615861 NA -0.37 -6.2 -0.36 2.14e-9 Eye color traits; CESC cis rs992157 0.560 rs6436048 chr2:219109033 C/T cg00012203 chr2:219082015 ARPC2 0.76 9.75 0.51 2.2e-19 Colorectal cancer; CESC cis rs9393777 0.588 rs6456727 chr6:26471155 T/C cg12826209 chr6:26865740 GUSBL1 0.59 7.13 0.4 9.69e-12 Intelligence (multi-trait analysis); CESC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg27170947 chr2:26402098 FAM59B 0.85 9.92 0.52 6.06e-20 Gut microbiome composition (summer); CESC cis rs61931739 0.534 rs11053047 chr12:34161084 C/T cg19457237 chr12:34500585 NA -0.39 -5.34 -0.31 1.99e-7 Morning vs. evening chronotype; CESC cis rs1045529 0.524 rs34251783 chr8:8891376 T/C cg15556689 chr8:8085844 FLJ10661 -0.5 -6.28 -0.36 1.41e-9 Myopia;Myopia (pathological); CESC cis rs35110281 0.591 rs189094 chr21:44932017 A/G cg21573476 chr21:45109991 RRP1B -0.41 -5.57 -0.32 6.4e-8 Mean corpuscular volume; CESC cis rs116095464 0.558 rs11959126 chr5:283880 T/G cg10591111 chr5:226296 SDHA -0.53 -6.43 -0.37 6.03e-10 Breast cancer; CESC cis rs916888 0.773 rs1378358 chr17:44787312 C/T cg15921436 chr17:44337874 NA 0.74 7.76 0.43 1.82e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9487051 0.803 rs410449 chr6:109539853 C/T cg01475377 chr6:109611718 NA -0.37 -5.29 -0.31 2.62e-7 Reticulocyte fraction of red cells; CESC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg22823121 chr1:150693482 HORMAD1 -0.36 -5.1 -0.3 6.39e-7 Melanoma; CESC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg17376030 chr22:41985996 PMM1 -0.56 -6.2 -0.36 2.14e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs7129220 0.588 rs77092969 chr11:10116298 G/A cg01453529 chr11:10209919 SBF2 -0.48 -5.48 -0.32 9.85e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs72615157 0.539 rs12673441 chr7:99670328 A/T cg22004693 chr7:99632812 ZKSCAN1 0.44 5.75 0.33 2.47e-8 Lung function (FEV1/FVC); CESC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg18512352 chr11:47633146 NA 0.44 6.31 0.36 1.18e-9 Subjective well-being; CESC cis rs9303280 0.806 rs13380815 chr17:38027583 A/G cg19468946 chr17:37922297 IKZF3 -0.41 -5.45 -0.32 1.16e-7 Self-reported allergy; CESC cis rs61996546 0.622 rs34886387 chr15:26862107 A/T cg15066197 chr15:26874202 GABRB3 -0.34 -5.05 -0.3 8.19e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs8073060 0.586 rs17638867 chr17:34052513 C/T cg19694781 chr19:47549865 TMEM160 0.68 6.31 0.36 1.15e-9 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC trans rs11722228 0.508 rs61335146 chr4:10130793 G/C cg26043149 chr18:55253948 FECH 0.91 11.52 0.58 3.54e-25 Gout;Urate levels;Serum uric acid levels; CESC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC cis rs1200821 0.529 rs2475206 chr10:37802532 A/G cg25427524 chr10:38739819 LOC399744 0.49 6.36 0.36 8.87e-10 Hemostatic factors and hematological phenotypes; CESC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg17427002 chr7:12443146 VWDE -0.56 -5.85 -0.34 1.42e-8 Coronary artery disease; CESC cis rs6582630 0.537 rs11520294 chr12:38402705 C/A cg26384229 chr12:38710491 ALG10B 0.73 10.79 0.55 9.99e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.36 6.72 0.38 1.1e-10 Electroencephalogram traits; CESC cis rs13242816 1.000 rs62468973 chr7:116125834 G/T cg04696780 chr7:116139425 CAV2 -0.62 -5.68 -0.33 3.58e-8 P wave duration; CESC cis rs10752881 1.000 rs10737236 chr1:182988608 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.83 -13.49 -0.64 6.39e-32 Colorectal cancer; CESC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg17143192 chr8:8559678 CLDN23 0.77 8.76 0.47 2.37e-16 Obesity-related traits; CESC cis rs6772849 1.000 rs2734037 chr3:128308884 C/T cg16766828 chr3:128327626 NA -0.32 -5.08 -0.3 7.08e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs2380220 0.808 rs2386669 chr6:95902121 C/T cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs9486719 1.000 rs10872018 chr6:97026429 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -8.37 -0.46 3.4e-15 Migraine;Coronary artery disease; CESC cis rs2439831 1.000 rs101094 chr15:43787322 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.17 0.6 2.26e-27 Lung cancer in ever smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08522065 chr12:46384600 SFRS2IP 0.59 6.99 0.39 2.24e-11 Gut microbiome composition (summer); CESC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg24829409 chr8:58192753 C8orf71 -0.53 -6.91 -0.39 3.49e-11 Developmental language disorder (linguistic errors); CESC cis rs6723226 0.732 rs390480 chr2:32510072 A/C cg02381751 chr2:32503542 YIPF4 -0.81 -11.64 -0.58 1.46e-25 Intelligence (multi-trait analysis); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17260383 chr8:22298246 PPP3CC 0.49 6.14 0.35 2.96e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.79 0.38 7.32e-11 Electroencephalogram traits; CESC cis rs3762637 1.000 rs9842736 chr3:122161101 C/T cg24169773 chr3:122142474 KPNA1 -0.54 -6.31 -0.36 1.2e-9 LDL cholesterol levels; CESC trans rs3942852 0.806 rs4752808 chr11:48141252 G/A cg03929089 chr4:120376271 NA -0.57 -6.33 -0.36 1.04e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs1008375 1.000 rs4698198 chr4:17656536 G/A cg16339924 chr4:17578868 LAP3 0.56 7.01 0.4 1.96e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs684232 0.623 rs2543779 chr17:576362 C/A cg15660573 chr17:549704 VPS53 -0.66 -9.03 -0.48 3.71e-17 Prostate cancer; CESC cis rs9457247 0.905 rs444210 chr6:167390242 A/G cg25258033 chr6:167368657 RNASET2 0.41 6.16 0.35 2.68e-9 Crohn's disease; CESC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg18252515 chr7:66147081 NA 0.4 5.2 0.3 4.06e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06148997 chr2:107084783 RGPD3 -0.59 -6.98 -0.39 2.39e-11 Gut microbiome composition (summer); CESC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs1707322 1.000 rs4390216 chr1:46266456 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.75 0.33 2.42e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs4523957 0.890 rs62069332 chr17:2112720 A/G cg16513277 chr17:2031491 SMG6 -0.65 -9.02 -0.48 4.04e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg00149659 chr3:10157352 C3orf10 1.0 11.96 0.59 1.22e-26 Alzheimer's disease; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg23508591 chr15:75871807 PTPN9 0.47 6.09 0.35 4.05e-9 Breast cancer;Type 2 diabetes; CESC cis rs736408 0.677 rs678 chr3:52820981 A/T cg18404041 chr3:52824283 ITIH1 -0.45 -7.3 -0.41 3.44e-12 Bipolar disorder; CESC cis rs1506636 1.000 rs641491 chr7:123399726 C/A cg03229431 chr7:123269106 ASB15 0.53 6.95 0.39 2.89e-11 Plateletcrit;Platelet count; CESC cis rs3820068 0.580 rs7512308 chr1:16006604 C/A cg13390004 chr1:15929781 NA 0.35 5.22 0.31 3.58e-7 Systolic blood pressure; CESC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.44 5.4 0.31 1.51e-7 Tonsillectomy; CESC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg04369109 chr6:150039330 LATS1 -0.44 -6.0 -0.35 6.58e-9 Lung cancer; CESC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg13628971 chr7:2884303 GNA12 -0.59 -7.72 -0.43 2.34e-13 Height; CESC cis rs4629180 0.586 rs10206804 chr2:102132431 C/T cg04415270 chr2:102091202 RFX8 0.3 5.23 0.31 3.46e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg22823121 chr1:150693482 HORMAD1 -0.35 -5.06 -0.3 7.82e-7 Tonsillectomy; CESC cis rs9894429 0.646 rs7406825 chr17:79619188 C/T cg18240062 chr17:79603768 NPLOC4 0.46 5.97 0.34 7.39e-9 Eye color traits; CESC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC cis rs7432375 0.610 rs60574021 chr3:136520281 C/G cg15507776 chr3:136538369 TMEM22 0.61 8.0 0.44 3.98e-14 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg26119090 chr2:26468346 HADHA;HADHB -0.63 -7.04 -0.4 1.69e-11 Gut microbiome composition (summer); CESC cis rs3733585 0.805 rs882222 chr4:9981294 G/A cg11266682 chr4:10021025 SLC2A9 0.62 12.69 0.61 3.76e-29 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4891159 0.548 rs11150952 chr18:74128188 T/C cg24786174 chr18:74118243 ZNF516 0.84 15.96 0.7 1.24e-40 Longevity; CESC cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg05283184 chr6:79620031 NA -0.41 -6.27 -0.36 1.48e-9 Intelligence (multi-trait analysis); CESC cis rs2795502 0.938 rs3121281 chr10:43400753 A/G cg20628663 chr10:43360327 NA 0.54 6.08 0.35 4.28e-9 Blood protein levels; CESC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg23978390 chr7:1156363 C7orf50 -0.45 -6.07 -0.35 4.4e-9 Longevity;Endometriosis; CESC trans rs61931739 0.534 rs12372557 chr12:34363843 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.2 0.36 2.16e-9 Morning vs. evening chronotype; CESC cis rs6987853 0.901 rs2974344 chr8:42400732 T/G cg09913449 chr8:42400586 C8orf40 0.4 6.34 0.36 9.76e-10 Mean corpuscular hemoglobin concentration; CESC cis rs2425143 1.000 rs2425149 chr20:34359587 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.82 -0.43 1.22e-13 Blood protein levels; CESC cis rs7927771 0.965 rs11039416 chr11:47846711 G/A cg05585544 chr11:47624801 NA -0.49 -7.71 -0.43 2.62e-13 Subjective well-being; CESC cis rs11264213 0.901 rs72661628 chr1:36406547 A/G cg27506609 chr1:36549197 TEKT2 0.66 5.59 0.32 5.62e-8 Schizophrenia; CESC cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.47 0.32 1.04e-7 Diabetic retinopathy; CESC cis rs2180341 0.782 rs6924274 chr6:127721556 T/A cg27446573 chr6:127587934 RNF146 0.79 11.35 0.57 1.36e-24 Breast cancer; CESC cis rs6089584 1.000 rs6089584 chr20:60564086 G/C cg24733560 chr20:60626293 TAF4 0.4 5.76 0.33 2.38e-8 Body mass index; CESC cis rs11945232 1.000 rs28372775 chr4:88343704 G/A cg23841344 chr4:88312519 HSD17B11 -0.66 -8.22 -0.45 9.16e-15 Intelligence (multi-trait analysis); CESC cis rs17655565 0.553 rs1945287 chr12:52733218 C/G cg00777198 chr12:52828273 KRT75 0.38 5.62 0.33 4.9e-8 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs9549367 0.713 rs3024776 chr13:113827075 A/G cg18105134 chr13:113819100 PROZ 0.7 8.54 0.46 1.05e-15 Platelet distribution width; CESC cis rs921968 0.541 rs2710246 chr2:219533894 C/T cg02176678 chr2:219576539 TTLL4 0.33 5.41 0.32 1.39e-7 Mean corpuscular hemoglobin concentration; CESC cis rs6732160 0.691 rs10197935 chr2:73412362 A/T cg01422370 chr2:73384389 NA 0.39 6.58 0.37 2.55e-10 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06187344 chr10:3151576 PFKP -0.53 -6.36 -0.36 8.63e-10 Gut microbiome composition (summer); CESC cis rs561341 0.654 rs6505265 chr17:30172580 C/T cg12193833 chr17:30244370 NA 0.58 5.49 0.32 9.28e-8 Hip circumference adjusted for BMI; CESC cis rs7937682 0.632 rs4441050 chr11:111772506 C/T cg09085632 chr11:111637200 PPP2R1B 0.88 11.26 0.57 2.77e-24 Primary sclerosing cholangitis; CESC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg11764359 chr7:65958608 NA -0.78 -11.32 -0.57 1.76e-24 Aortic root size; CESC cis rs1023500 0.551 rs133355 chr22:42440285 G/A cg15557168 chr22:42548783 NA -0.45 -6.35 -0.36 9.27e-10 Schizophrenia; CESC cis rs11792861 0.926 rs72607171 chr9:111837776 T/C cg13535736 chr9:111863775 C9orf5 -0.51 -6.76 -0.38 8.77e-11 Menarche (age at onset); CESC cis rs9796 0.653 rs28516683 chr15:41446645 A/G cg12426344 chr15:41135900 SPINT1 -0.25 -5.51 -0.32 8.63e-8 Menopause (age at onset); CESC cis rs6963495 0.818 rs73190186 chr7:105164368 G/C cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs7223966 1.000 rs9912904 chr17:61763534 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.44 0.37 5.7e-10 Hip circumference adjusted for BMI;Body mass index; CESC trans rs9329221 0.512 rs7843924 chr8:9976540 C/T cg15556689 chr8:8085844 FLJ10661 0.49 6.28 0.36 1.4e-9 Neuroticism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17499729 chr21:37504755 NA -0.45 -6.1 -0.35 3.71e-9 Gut microbiota (bacterial taxa); CESC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg07952391 chr2:88470173 THNSL2 0.64 6.21 0.36 2.05e-9 Plasma clusterin levels; CESC cis rs7665939 1.000 rs72727637 chr4:190106678 G/T cg14840187 chr4:190284988 NA -0.84 -6.95 -0.39 2.9100000000000002e-11 Amyotrophic lateral sclerosis; CESC cis rs1538970 0.924 rs3790582 chr1:45887288 T/C cg06784218 chr1:46089804 CCDC17 0.32 5.21 0.3 3.89e-7 Platelet count; CESC cis rs7659604 0.521 rs4833234 chr4:122694799 T/C cg19671926 chr4:122722719 EXOSC9 0.64 8.56 0.47 9.28e-16 Type 2 diabetes; CESC cis rs116988415 0.584 rs4899145 chr14:65241867 G/A cg25083366 chr14:65239357 SPTB 0.69 5.05 0.3 8.08e-7 Daytime sleep phenotypes; CESC cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg04450456 chr4:17643702 FAM184B 0.37 5.18 0.3 4.46e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6831352 0.918 rs13127582 chr4:100058194 G/A cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs34779708 0.966 rs17500582 chr10:35498788 T/A cg03585969 chr10:35415529 CREM 0.75 9.88 0.52 8.37e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs763014 0.833 rs3743904 chr16:632767 A/G cg07256732 chr16:621771 PIGQ -0.31 -5.3 -0.31 2.4e-7 Height; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg18689148 chr7:157738329 PTPRN2 0.5 6.08 0.35 4.1e-9 Subjective well-being; CESC cis rs9913156 0.748 rs72835619 chr17:4557285 G/A cg00122941 chr17:4613640 ARRB2 0.84 9.91 0.52 6.58e-20 Lymphocyte counts; CESC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg06074448 chr4:187884817 NA -0.37 -5.44 -0.32 1.21e-7 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02750954 chr17:40847780 CNTNAP1 -0.43 -6.07 -0.35 4.43e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs1331644 chr6:146398660 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.57 0.37 2.58e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2290159 0.800 rs6766666 chr3:12690855 A/C cg23032965 chr3:12705835 RAF1 -0.5 -5.4 -0.31 1.47e-7 Cholesterol, total; CESC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.84 11.79 0.59 4.52e-26 Age-related macular degeneration (geographic atrophy); CESC cis rs4704187 0.687 rs6872475 chr5:74419793 G/A cg03227963 chr5:74354835 NA 0.31 5.7 0.33 3.22e-8 Response to amphetamines; CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg06877462 chr1:205807181 PM20D1 0.42 6.35 0.36 9.46e-10 Menarche (age at onset); CESC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.51 -6.36 -0.36 8.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8170 0.603 rs3745187 chr19:17414126 C/T cg04749549 chr19:17459798 NA -0.33 -5.33 -0.31 2.15e-7 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CESC cis rs11577318 0.853 rs1071849 chr1:26646726 A/G cg18121669 chr1:26560928 CCDC21 0.42 5.07 0.3 7.54e-7 Granulocyte percentage of myeloid white cells; CESC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg06634786 chr22:41940651 POLR3H -0.64 -6.62 -0.38 2.01e-10 Vitiligo; CESC cis rs16854884 0.584 rs34372603 chr3:143738249 T/C cg06585982 chr3:143692056 C3orf58 0.5 6.7 0.38 1.26e-10 Economic and political preferences (feminism/equality); CESC cis rs1707322 1.000 rs4660334 chr1:46462126 A/C cg03146154 chr1:46216737 IPP 0.71 9.58 0.51 7.4e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg17509989 chr5:176798049 RGS14 0.6 6.35 0.36 9.46e-10 Urinary electrolytes (magnesium/calcium ratio); CESC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC cis rs10197940 0.710 rs4500942 chr2:152334580 A/G cg06191203 chr2:152266755 RIF1 -0.44 -5.53 -0.32 7.84e-8 Lung cancer; CESC cis rs1790761 0.505 rs7938563 chr11:67304131 A/G cg24690094 chr11:67383802 NA -0.33 -5.67 -0.33 3.72e-8 Mean corpuscular volume; CESC cis rs3008870 0.916 rs2025608 chr1:67422550 C/T cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs933688 0.941 rs2887007 chr5:90740531 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.09 14.69 0.67 3.85e-36 Smoking behavior; CESC cis rs7116495 0.609 rs7113520 chr11:71691946 G/A cg26138937 chr11:71823887 C11orf51 -1.32 -8.29 -0.45 5.9e-15 Severe influenza A (H1N1) infection; CESC trans rs35952432 1 rs35952432 chr6:28074901 C/T cg06606381 chr12:133084897 FBRSL1 -1.08 -8.08 -0.44 2.26e-14 Lung cancer; CESC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg10253484 chr15:75165896 SCAMP2 -0.54 -7.12 -0.4 1.01e-11 Breast cancer; CESC cis rs5850 0.557 rs10270788 chr7:23189000 T/C cg23682824 chr7:23144976 KLHL7 0.51 6.83 0.39 5.81e-11 Blood protein levels; CESC cis rs2370759 1.000 rs2225152 chr10:32574759 T/C cg05361325 chr10:32636312 EPC1 -0.54 -5.12 -0.3 6e-7 Sexual dysfunction (female); CESC cis rs6088590 1.000 rs6058111 chr20:33310999 T/C cg08999081 chr20:33150536 PIGU 0.58 9.0 0.48 4.6e-17 Coronary artery disease; CESC cis rs1847202 0.859 rs13096870 chr3:72948172 G/A cg25664220 chr3:72788482 NA -0.38 -5.49 -0.32 9.25e-8 Motion sickness; CESC cis rs4076764 0.914 rs6704467 chr1:163364512 A/G cg24596788 chr1:163392923 NA -0.5 -7.56 -0.42 6.74e-13 Motion sickness; CESC cis rs7589342 1.000 rs7589342 chr2:106433478 C/T cg16077055 chr2:106428750 NCK2 0.53 7.56 0.42 6.6e-13 Addiction; CESC cis rs7818688 1.000 rs10113545 chr8:96029707 A/T cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg19468946 chr17:37922297 IKZF3 0.39 5.03 0.3 8.9e-7 Glomerular filtration rate (creatinine); CESC cis rs9894429 0.546 rs9906979 chr17:79608765 A/G cg21984481 chr17:79567631 NPLOC4 -0.4 -6.04 -0.35 5.26e-9 Eye color traits; CESC cis rs6831352 0.918 rs35662508 chr4:100050974 C/G cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs611744 0.816 rs626211 chr8:109189448 A/C cg21045802 chr8:109455806 TTC35 0.46 5.51 0.32 8.7e-8 Dupuytren's disease; CESC cis rs36051895 0.587 rs16922785 chr9:5200409 C/G cg02405213 chr9:5042618 JAK2 -0.49 -5.52 -0.32 8.03e-8 Pediatric autoimmune diseases; CESC cis rs9868809 0.881 rs2276852 chr3:48666923 A/G cg06212747 chr3:49208901 KLHDC8B -0.6 -5.34 -0.31 1.96e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs4148883 0.675 rs10015824 chr4:100074544 C/G cg12011299 chr4:100065546 ADH4 0.67 9.97 0.52 4.3e-20 Alcohol dependence; CESC cis rs77956314 0.515 rs4767473 chr12:117365506 C/T cg25972092 chr12:117363249 FBXW8 0.52 5.85 0.34 1.43e-8 Subcortical brain region volumes;Hippocampal volume; CESC cis rs16854884 0.657 rs7637912 chr3:143749777 G/A cg06585982 chr3:143692056 C3orf58 0.5 6.71 0.38 1.18e-10 Economic and political preferences (feminism/equality); CESC cis rs2228479 0.717 rs9282682 chr16:89805794 A/G cg04013166 chr16:89971882 TCF25 0.72 7.9 0.44 7.6e-14 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02884024 chr20:58515388 C20orf177;PPP1R3D 0.59 6.48 0.37 4.47e-10 Gut microbiome composition (summer); CESC cis rs77861329 0.748 rs731684 chr3:52109841 T/C cg08692210 chr3:52188851 WDR51A 0.5 6.08 0.35 4.12e-9 Macrophage inflammatory protein 1b levels; CESC cis rs8170 0.603 rs8109328 chr19:17417955 C/T cg04749549 chr19:17459798 NA -0.34 -5.34 -0.31 2.01e-7 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CESC cis rs13343954 0.518 rs7252086 chr19:33534929 T/C cg03563238 chr19:33554763 RHPN2 -0.31 -5.56 -0.32 6.65e-8 Colorectal cancer; CESC cis rs9911578 0.904 rs7209253 chr17:56908987 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 3.04e-7 Intelligence (multi-trait analysis); CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg24503407 chr1:205819492 PM20D1 0.9 16.55 0.71 9.63e-43 Menarche (age at onset); CESC cis rs61776719 0.520 rs12569027 chr1:38449163 C/T cg12658694 chr1:38397304 INPP5B 0.65 9.39 0.5 2.82e-18 Coronary artery disease; CESC cis rs9902453 1.000 rs7207021 chr17:28400516 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.63 -8.05 -0.44 2.78e-14 Coffee consumption (cups per day); CESC trans rs1973993 0.544 rs2800427 chr1:97002766 A/C cg10631902 chr5:14652156 NA 0.46 6.89 0.39 4.05e-11 Weight; CESC cis rs1499972 0.648 rs62264764 chr3:117639575 G/A cg07612923 chr3:117604196 NA 0.66 5.98 0.34 7.1e-9 Schizophrenia; CESC cis rs7927771 0.560 rs4752858 chr11:47685829 C/T cg20307385 chr11:47447363 PSMC3 -0.58 -8.03 -0.44 3.19e-14 Subjective well-being; CESC cis rs7131987 0.903 rs2194518 chr12:29419460 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -5.1 -0.3 6.36e-7 QT interval; CESC cis rs854765 0.547 rs6502633 chr17:17941037 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.36 0.36 8.59e-10 Total body bone mineral density; CESC cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.67 8.7 0.47 3.62e-16 Age-related macular degeneration (geographic atrophy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05527336 chr4:83956057 COPS4 -0.56 -6.14 -0.35 2.98e-9 Gut microbiome composition (summer); CESC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg10792982 chr14:105748885 BRF1 0.42 5.52 0.32 7.89e-8 Mean platelet volume;Platelet distribution width; CESC cis rs2242663 0.529 rs1785640 chr11:66223158 C/T cg04006266 chr11:66300458 BBS1 0.33 5.08 0.3 7.12e-7 Bipolar disorder; CESC cis rs3091242 0.933 rs61775174 chr1:25787313 G/A cg27572855 chr1:25598939 RHD -0.43 -6.95 -0.39 2.79e-11 Erythrocyte sedimentation rate; CESC cis rs7589728 1.000 rs7589728 chr2:88518440 G/A cg04511125 chr2:88470314 THNSL2 0.59 5.73 0.33 2.68e-8 Plasma clusterin levels; CESC cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg05347473 chr6:146136440 FBXO30 0.59 7.78 0.43 1.59e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs2120019 1.000 rs12324912 chr15:75361006 G/A cg17294928 chr15:75287854 SCAMP5 -0.68 -7.51 -0.42 8.84e-13 Blood trace element (Zn levels); CESC cis rs2204008 0.506 rs11495470 chr12:38026904 C/T cg13010199 chr12:38710504 ALG10B 0.47 5.83 0.34 1.62e-8 Bladder cancer; CESC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg06456125 chr7:65229604 NA -0.41 -5.36 -0.31 1.79e-7 Aortic root size; CESC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg05313129 chr8:58192883 C8orf71 -0.53 -6.09 -0.35 3.95e-9 Developmental language disorder (linguistic errors); CESC trans rs61931739 0.963 rs12307606 chr12:34016365 C/T cg26384229 chr12:38710491 ALG10B -0.46 -6.31 -0.36 1.16e-9 Morning vs. evening chronotype; CESC trans rs11637445 0.627 rs4776988 chr15:68124151 C/T cg14583481 chr3:118865028 C3orf30;IGSF11 0.43 6.19 0.36 2.22e-9 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg01238044 chr22:24384105 GSTT1 0.65 7.85 0.43 1.04e-13 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg11502198 chr6:26597334 ABT1 0.52 5.31 0.31 2.35e-7 Intelligence (multi-trait analysis); CESC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.37 0.31 1.7e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg01448562 chr3:133502909 NA -0.44 -6.09 -0.35 4.06e-9 Iron status biomarkers; CESC cis rs11264213 0.901 rs72661632 chr1:36420715 G/A cg27506609 chr1:36549197 TEKT2 0.67 5.55 0.32 6.97e-8 Schizophrenia; CESC cis rs12476592 0.516 rs6706123 chr2:63801522 G/A cg17519650 chr2:63277830 OTX1 -0.48 -5.82 -0.34 1.66e-8 Childhood ear infection; CESC cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs36051895 0.626 rs3780368 chr9:5093188 G/C cg02405213 chr9:5042618 JAK2 -0.54 -6.57 -0.37 2.58e-10 Pediatric autoimmune diseases; CESC cis rs920590 0.721 rs67989257 chr8:19660278 G/A cg17834443 chr8:19674713 INTS10 0.59 6.6 0.38 2.2e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs965469 0.895 rs6037592 chr20:3392950 T/G cg25506879 chr20:3388711 C20orf194 -0.63 -6.63 -0.38 1.92e-10 IFN-related cytopenia; CESC cis rs807669 0.807 rs712948 chr22:19206499 A/G cg02655711 chr22:19163373 SLC25A1 0.9 13.11 0.63 1.31e-30 Metabolite levels; CESC cis rs7267979 1.000 rs3761117 chr20:25388070 G/A cg08601574 chr20:25228251 PYGB -0.37 -5.32 -0.31 2.18e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs6963495 0.818 rs73192149 chr7:105210910 A/G cg02135003 chr7:105160482 PUS7 -0.48 -5.62 -0.33 4.83e-8 Bipolar disorder (body mass index interaction); CESC cis rs35110281 0.715 rs8129601 chr21:45119104 A/G cg04455712 chr21:45112962 RRP1B 0.5 7.81 0.43 1.38e-13 Mean corpuscular volume; CESC cis rs8077577 0.747 rs57490980 chr17:18160753 T/A cg16794390 chr17:18148240 FLII 0.41 6.33 0.36 1.05e-9 Obesity-related traits; CESC trans rs61931739 0.500 rs11053246 chr12:34516620 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.31e-22 Morning vs. evening chronotype; CESC cis rs2985684 0.894 rs6572586 chr14:50021941 A/C cg02151108 chr14:50098012 C14orf104 -0.4 -5.35 -0.31 1.92e-7 Carotid intima media thickness; CESC cis rs2635047 0.967 rs1119005 chr18:44725605 A/G cg24371990 chr18:44770781 NA 0.33 5.3 0.31 2.48e-7 Educational attainment; CESC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg15145296 chr3:125709740 NA -0.56 -5.97 -0.34 7.65e-9 Blood pressure (smoking interaction); CESC cis rs9388451 0.807 rs1269175 chr6:126040435 A/G cg05901451 chr6:126070800 HEY2 0.61 8.99 0.48 4.68e-17 Brugada syndrome; CESC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.57 0.37 2.69e-10 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16341945 chr7:111846878 ZNF277;DOCK4 -0.57 -6.53 -0.37 3.38e-10 Gut microbiome composition (summer); CESC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg19592336 chr6:28129416 ZNF389 0.44 6.46 0.37 4.98e-10 Cardiac Troponin-T levels; CESC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg10691866 chr7:65817282 TPST1 -0.35 -5.91 -0.34 1.06e-8 Aortic root size; CESC cis rs116095464 0.558 rs10075018 chr5:239175 G/A cg10591111 chr5:226296 SDHA -0.51 -6.22 -0.36 1.95e-9 Breast cancer; CESC cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg12386194 chr3:101231763 SENP7 0.45 5.74 0.33 2.63e-8 Colorectal cancer; CESC cis rs10392 0.543 rs6028208 chr20:37556075 T/A cg27552599 chr20:37590471 DHX35 0.38 5.79 0.34 1.94e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs7312933 0.669 rs7974476 chr12:42542484 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.42 5.47 0.32 1.02e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6429637 0.542 rs12760274 chr1:44249344 C/T cg19743044 chr1:44115203 KDM4A -0.42 -5.04 -0.3 8.55e-7 Intelligence (multi-trait analysis); CESC cis rs4077515 0.967 rs11794847 chr9:139271747 G/A cg14169450 chr9:139327907 INPP5E 0.37 5.42 0.32 1.31e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs12822507 0.868 rs12580006 chr12:12789646 C/T cg04607235 chr12:12878440 APOLD1 -0.51 -6.57 -0.37 2.6200000000000003e-10 Systemic lupus erythematosus; CESC cis rs10883723 0.810 rs61873733 chr10:104251458 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.44 0.42 1.43e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs10463316 0.709 rs3857426 chr5:150789831 C/A cg03212797 chr5:150827313 SLC36A1 -0.49 -6.46 -0.37 4.89e-10 Metabolite levels (Pyroglutamine); CESC trans rs61931739 0.534 rs1843733 chr12:34047626 T/C cg26384229 chr12:38710491 ALG10B 0.51 6.94 0.39 2.97e-11 Morning vs. evening chronotype; CESC cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.54 0.32 7.25e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9905704 0.874 rs2643126 chr17:56737765 A/G cg12560992 chr17:57184187 TRIM37 0.59 7.03 0.4 1.72e-11 Testicular germ cell tumor; CESC cis rs7264396 0.690 rs2425171 chr20:34443173 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.35 0.41 2.49e-12 Total cholesterol levels; CESC cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25449970 chr10:5550506 NA -0.57 -6.67 -0.38 1.47e-10 Gut microbiome composition (summer); CESC cis rs5769765 0.779 rs12170530 chr22:50318422 T/G cg26441486 chr22:50317300 CRELD2 0.48 5.78 0.33 2.08e-8 Schizophrenia; CESC cis rs10465746 0.780 rs2147392 chr1:84404154 C/A cg10977910 chr1:84465055 TTLL7 0.53 7.22 0.41 5.43e-12 Obesity-related traits; CESC cis rs2645424 0.686 rs2294140 chr8:11705677 C/G cg21281001 chr8:11725306 CTSB -0.42 -5.42 -0.32 1.31e-7 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); CESC cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg18357645 chr12:58087776 OS9 -0.43 -5.94 -0.34 9.06e-9 Multiple sclerosis; CESC cis rs2732480 0.500 rs2450989 chr12:48653408 A/G cg24011408 chr12:48396354 COL2A1 -0.43 -6.11 -0.35 3.52e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2180341 0.596 rs12215298 chr6:127676833 C/T cg27446573 chr6:127587934 RNF146 0.78 10.47 0.54 1.11e-21 Breast cancer; CESC cis rs2228479 0.850 rs17226498 chr16:89840631 T/C cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg08470875 chr2:26401718 FAM59B 0.7 7.18 0.4 6.92e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08492205 chr10:103879827 LDB1 -0.66 -7.88 -0.44 8.47e-14 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs55678971 chr3:52717229 T/A cg17372223 chr3:52568218 NT5DC2 0.48 7.27 0.41 4.02e-12 Bipolar disorder; CESC cis rs3733585 0.673 rs6840802 chr4:9965633 C/G cg02734326 chr4:10020555 SLC2A9 0.43 5.82 0.34 1.73e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg25554036 chr4:6271136 WFS1 0.51 8.48 0.46 1.65e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6426558 0.515 rs7543579 chr1:227377699 A/T cg10327440 chr1:227177885 CDC42BPA -0.5 -6.17 -0.35 2.56e-9 Neutrophil percentage of white cells; CESC cis rs96067 0.652 rs274764 chr1:36574912 T/C cg27506609 chr1:36549197 TEKT2 -0.44 -5.34 -0.31 1.97e-7 Corneal structure; CESC cis rs763121 0.925 rs1056661 chr22:39080245 A/G cg06022373 chr22:39101656 GTPBP1 0.79 12.97 0.62 4.12e-30 Menopause (age at onset); CESC cis rs10857712 0.904 rs7083614 chr10:135226236 G/A cg01444801 chr10:135216882 MTG1 -0.45 -5.3 -0.31 2.49e-7 Systemic lupus erythematosus; CESC cis rs453301 0.592 rs4841084 chr8:8883905 C/T cg06636001 chr8:8085503 FLJ10661 0.46 5.93 0.34 9.51e-9 Joint mobility (Beighton score); CESC cis rs6460942 0.630 rs17670901 chr7:12386622 G/A cg02935154 chr7:12443704 VWDE -0.5 -5.17 -0.3 4.6e-7 Coronary artery disease; CESC cis rs9522267 0.535 rs9522284 chr13:112229343 C/T cg10483660 chr13:112241077 NA -0.33 -5.82 -0.34 1.67e-8 Hepatitis; CESC cis rs2708240 1.000 rs759178 chr7:147575112 A/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.23e-8 QT interval (drug interaction); CESC cis rs66823261 0.778 rs2906332 chr8:194943 C/T cg27532244 chr8:182981 ZNF596;RPL23AP53 -0.57 -6.65 -0.38 1.64e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs7937682 0.889 rs2850247 chr11:111637202 C/A cg22437258 chr11:111473054 SIK2 -0.64 -7.72 -0.43 2.43e-13 Primary sclerosing cholangitis; CESC trans rs1829883 0.733 rs28521637 chr5:98725123 A/C cg23861655 chr4:57411219 NA 0.38 6.25 0.36 1.68e-9 Hemostatic factors and hematological phenotypes; CESC cis rs4722166 0.573 rs35436671 chr7:22775508 G/A cg26061582 chr7:22766209 IL6 0.52 5.64 0.33 4.41e-8 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22513511 chr1:151162618 VPS72 0.59 6.29 0.36 1.29e-9 Gut microbiome composition (summer); CESC trans rs62103177 0.810 rs62103192 chr18:77629050 A/T cg05926928 chr17:57297772 GDPD1 1.18 10.14 0.53 1.27e-20 Opioid sensitivity; CESC cis rs9896933 0.778 rs80112422 chr17:80827719 G/T cg19500275 chr17:80737654 TBCD 0.62 5.88 0.34 1.23e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs4253772 0.637 rs6008357 chr22:46652104 T/G cg24881330 chr22:46731750 TRMU 0.89 10.09 0.53 1.86e-20 LDL cholesterol;Cholesterol, total; CESC cis rs2066819 1.000 rs116535779 chr12:56739261 A/G cg26734620 chr12:56694298 CS 0.88 8.75 0.47 2.56e-16 Psoriasis vulgaris; CESC cis rs2439831 1.000 rs689826 chr15:43749916 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.82 12.06 0.6 5.55e-27 Lung cancer in ever smokers; CESC cis rs6087990 0.806 rs1474738 chr20:31380309 G/A cg13636640 chr20:31349939 DNMT3B 0.77 11.88 0.59 2.17e-26 Ulcerative colitis; CESC cis rs12422267 0.609 rs11246940 chr12:132623473 A/G cg09764611 chr12:132620959 NA -0.52 -6.52 -0.37 3.52e-10 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs4953076 0.533 rs1551315 chr2:44407618 G/A cg04920474 chr2:44395004 PPM1B 0.54 6.83 0.39 5.76e-11 Height; CESC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Depression; CESC cis rs4805272 0.512 rs11879141 chr19:29320335 G/A cg12756686 chr19:29218302 NA 0.5 6.28 0.36 1.39e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs2228479 0.850 rs76075456 chr16:89834270 T/C cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs11098499 0.708 rs11732686 chr4:120252330 C/A cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs10752881 1.000 rs8179262 chr1:182973186 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.44 0.64 9.35e-32 Colorectal cancer; CESC cis rs12618769 0.597 rs4851142 chr2:99133611 A/C cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs12410462 0.581 rs73102371 chr1:227554880 G/A cg04117972 chr1:227635322 NA 0.62 5.3 0.31 2.42e-7 Major depressive disorder; CESC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.99e-8 Eye color traits; CESC cis rs10876993 0.890 rs1689597 chr12:58051886 G/A cg18357645 chr12:58087776 OS9 0.61 9.4 0.5 2.71e-18 Celiac disease or Rheumatoid arthritis; CESC cis rs317689 0.513 rs317678 chr12:69692166 C/G cg20891283 chr12:69753455 YEATS4 0.56 7.09 0.4 1.21e-11 Response to diuretic therapy; CESC cis rs11155671 0.530 rs7757984 chr6:150208651 A/G cg09699651 chr6:150184138 LRP11 0.54 7.48 0.42 1.07e-12 Testicular germ cell tumor; CESC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg18876405 chr7:65276391 NA -0.45 -6.18 -0.35 2.43e-9 Aortic root size; CESC cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg04478727 chr12:58166393 METTL1;FAM119B 0.71 8.96 0.48 5.78e-17 Multiple sclerosis; CESC cis rs60154123 0.730 rs652256 chr1:210465017 T/C cg25204440 chr1:209979598 IRF6 0.45 5.05 0.3 8.23e-7 Coronary artery disease; CESC trans rs2727020 0.894 rs10839265 chr11:49369733 C/T cg15704280 chr7:45808275 SEPT13 -0.76 -9.47 -0.5 1.61e-18 Coronary artery disease; CESC cis rs9457247 1.000 rs10946199 chr6:167404492 G/A cg23791538 chr6:167370224 RNASET2 -0.58 -8.28 -0.45 6.28e-15 Crohn's disease; CESC cis rs9486715 0.867 rs3860243 chr6:96905303 T/G cg18709589 chr6:96969512 KIAA0776 0.46 6.47 0.37 4.68e-10 Headache; CESC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg03395511 chr6:291903 DUSP22 -0.72 -9.41 -0.5 2.54e-18 Menopause (age at onset); CESC cis rs9314323 0.767 rs10866848 chr8:26208209 G/C cg11498726 chr8:26250323 BNIP3L -0.47 -6.71 -0.38 1.19e-10 Red cell distribution width; CESC cis rs7599312 0.532 rs1531788 chr2:213394320 C/T cg16329650 chr2:213403929 ERBB4 0.4 5.32 0.31 2.17e-7 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs863345 0.526 rs857723 chr1:158604000 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -5.6 -0.33 5.4e-8 Pneumococcal bacteremia; CESC cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg26874164 chr19:58962979 ZNF324B 0.54 7.66 0.43 3.55e-13 Uric acid clearance; CESC cis rs3862030 0.694 rs1984795 chr10:104226830 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.37 -5.17 -0.3 4.71e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg06494592 chr3:125709126 NA -0.51 -5.44 -0.32 1.22e-7 Blood pressure (smoking interaction); CESC cis rs7561273 0.561 rs35268318 chr2:24352824 A/T cg20701182 chr2:24300061 SF3B14 0.46 6.01 0.35 6.27e-9 Quantitative traits; CESC cis rs8067354 0.574 rs9789060 chr17:58018570 A/G cg02344993 chr17:57696989 CLTC 0.53 5.56 0.32 6.6e-8 Hemoglobin concentration; CESC cis rs2204008 0.837 rs12366727 chr12:38365748 A/C cg26384229 chr12:38710491 ALG10B 0.73 10.65 0.55 2.87e-22 Bladder cancer; CESC cis rs6032067 0.777 rs80323300 chr20:43785287 T/C cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs10088262 0.629 rs7827665 chr8:124804190 G/A cg20713898 chr8:124780851 FAM91A1 -0.66 -8.96 -0.48 6.13e-17 Pancreatic cancer; CESC cis rs7918232 0.941 rs10829195 chr10:27431564 G/A cg14240646 chr10:27532245 ACBD5 -0.66 -6.43 -0.37 5.89e-10 Breast cancer; CESC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg01448562 chr3:133502909 NA 0.39 5.47 0.32 1.03e-7 Iron status biomarkers; CESC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.91 0.39 3.67e-11 Electroencephalogram traits; CESC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg23281280 chr6:28129359 ZNF389 0.49 6.85 0.39 5.22e-11 Depression; CESC cis rs963731 0.649 rs6713281 chr2:39235330 G/T cg04010122 chr2:39346883 SOS1 -0.72 -5.65 -0.33 4.12e-8 Corticobasal degeneration; CESC cis rs782590 0.837 rs809732 chr2:55914621 T/C cg18811423 chr2:55921094 PNPT1 0.8 12.8 0.62 1.6e-29 Metabolic syndrome; CESC cis rs7089973 0.584 rs7908665 chr10:116611337 G/A cg23260525 chr10:116636907 FAM160B1 0.43 8.28 0.45 6.14e-15 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6066835 1.000 rs742645 chr20:47323655 G/A cg18078177 chr20:47281410 PREX1 0.72 5.1 0.3 6.38e-7 Multiple myeloma; CESC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg07677032 chr17:61819896 STRADA 0.42 5.25 0.31 3.15e-7 Height; CESC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg04267008 chr7:1944627 MAD1L1 -0.48 -5.52 -0.32 8.09e-8 Schizophrenia; CESC cis rs17125944 0.615 rs8019585 chr14:53374843 G/A cg00686598 chr14:53173677 PSMC6 0.64 5.31 0.31 2.3e-7 Alzheimer's disease (late onset); CESC cis rs4604732 0.631 rs74154675 chr1:247625836 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12765878 1.000 rs3850671 chr10:105659387 T/C cg24587175 chr10:105670608 OBFC1 0.34 5.57 0.32 6.31e-8 Coronary artery disease; CESC cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6500395 1.000 rs6500402 chr16:48687354 C/T cg04672837 chr16:48644449 N4BP1 0.51 6.4 0.37 6.98e-10 Response to tocilizumab in rheumatoid arthritis; CESC trans rs637571 0.565 rs570387 chr11:65637076 T/C cg17712092 chr4:129076599 LARP1B -0.74 -9.4 -0.5 2.64e-18 Eosinophil percentage of white cells; CESC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg13393036 chr8:95962371 TP53INP1 0.47 9.07 0.49 2.78e-17 Type 2 diabetes; CESC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg07395648 chr5:131743802 NA -0.47 -6.13 -0.35 3.15e-9 Breast cancer; CESC cis rs7666738 0.830 rs1456208 chr4:98678563 C/T cg03467027 chr4:99064603 C4orf37 0.43 5.27 0.31 2.89e-7 Colonoscopy-negative controls vs population controls; CESC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg18252515 chr7:66147081 NA 0.48 6.46 0.37 5.06e-10 Aortic root size; CESC cis rs2228479 0.850 rs17226428 chr16:89842884 T/A cg04013166 chr16:89971882 TCF25 0.78 6.67 0.38 1.51e-10 Skin colour saturation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14787260 chr17:40428794 STAT5B -0.48 -6.66 -0.38 1.53e-10 Gut microbiota (bacterial taxa); CESC cis rs7208859 0.623 rs1061343 chr17:29114276 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs7246657 0.891 rs7253114 chr19:37988725 G/A cg24637308 chr11:6592297 DNHD1 0.52 6.16 0.35 2.66e-9 Coronary artery calcification; CESC trans rs11098499 0.913 rs13126596 chr4:120140729 A/G cg25214090 chr10:38739885 LOC399744 0.63 8.33 0.46 4.44e-15 Corneal astigmatism; CESC cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg00409905 chr10:38381863 ZNF37A -0.45 -6.04 -0.35 5.25e-9 Extrinsic epigenetic age acceleration; CESC cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg13147721 chr7:65941812 NA -0.95 -9.04 -0.49 3.39e-17 Diabetic kidney disease; CESC cis rs9399401 0.667 rs11759653 chr6:142720354 G/A cg03128060 chr6:142623767 GPR126 0.38 6.4 0.37 7.02e-10 Chronic obstructive pulmonary disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01439366 chr20:388553 RBCK1 0.55 6.05 0.35 5.03e-9 Gut microbiome composition (summer); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23104823 chr14:45553408 PRPF39 -0.45 -6.14 -0.35 2.94e-9 Height; CESC cis rs9611565 0.918 rs12484074 chr22:41752747 G/A cg06634786 chr22:41940651 POLR3H -0.65 -6.52 -0.37 3.51e-10 Vitiligo; CESC cis rs7959452 0.684 rs11177615 chr12:69754189 G/A cg22834771 chr12:69754056 YEATS4 -0.43 -5.55 -0.32 6.87e-8 Blood protein levels; CESC cis rs67311347 0.869 rs9832311 chr3:40381322 A/T cg24209194 chr3:40518798 ZNF619 0.43 5.49 0.32 9.27e-8 Renal cell carcinoma; CESC cis rs1395 0.744 rs3739092 chr2:27462076 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.45 5.85 0.34 1.46e-8 Blood metabolite levels; CESC cis rs72945132 0.882 rs7935969 chr11:70194175 G/A cg00319359 chr11:70116639 PPFIA1 0.72 6.84 0.39 5.42e-11 Coronary artery disease; CESC cis rs4642101 0.561 rs9831765 chr3:12805934 A/T cg24848339 chr3:12840334 CAND2 0.34 5.2 0.3 4.03e-7 QRS complex (12-leadsum); CESC cis rs1153858 1.000 rs11070453 chr15:45645154 C/G cg21132104 chr15:45694354 SPATA5L1 0.84 11.4 0.57 9.5e-25 Homoarginine levels; CESC cis rs1371867 0.875 rs962451 chr8:101331010 C/T cg11906718 chr8:101322791 RNF19A 0.53 6.77 0.38 8.21e-11 Atrioventricular conduction; CESC cis rs1707322 0.964 rs6675259 chr1:46502295 G/A cg03146154 chr1:46216737 IPP -0.76 -9.79 -0.52 1.66e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.7 -7.86 -0.43 9.43e-14 Gut microbiome composition (summer); CESC cis rs6991838 0.584 rs1053085 chr8:66515988 C/T cg13398993 chr8:66546079 ARMC1 -0.46 -5.45 -0.32 1.14e-7 Intelligence (multi-trait analysis); CESC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.99e-8 Eye color traits; CESC cis rs4822044 0.568 rs1883370 chr22:42143740 C/A cg03806693 chr22:41940476 POLR3H 1.18 13.78 0.65 6.21e-33 Cannabis dependence symptom count; CESC cis rs734999 0.572 rs3748816 chr1:2526746 A/G cg20673091 chr1:2541236 MMEL1 0.44 7.44 0.42 1.39e-12 Ulcerative colitis; CESC cis rs5769707 0.837 rs5770599 chr22:50019981 C/G cg05373962 chr22:49881684 NA -0.37 -6.14 -0.35 3.04e-9 Monocyte count;Monocyte percentage of white cells; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10900715 chr6:41034675 C6orf130 0.46 6.26 0.36 1.57e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg16652648 chr2:197791396 PGAP1 0.48 5.99 0.35 6.64e-9 Psoriatic arthritis; CESC cis rs80282103 0.717 rs41299206 chr10:1120236 T/C cg08668510 chr10:1095578 IDI1 0.73 5.86 0.34 1.39e-8 Glomerular filtration rate (creatinine); CESC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg18404041 chr3:52824283 ITIH1 -0.4 -6.72 -0.38 1.1e-10 Bipolar disorder; CESC cis rs17209837 1.000 rs45447097 chr7:87086144 G/A cg00919237 chr7:87102261 ABCB4 -0.49 -5.77 -0.33 2.23e-8 Gallbladder cancer; CESC trans rs7746199 0.736 rs34573979 chr6:27480526 C/T cg06606381 chr12:133084897 FBRSL1 -1.07 -8.9 -0.48 9.12e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs7223966 1.000 rs6504169 chr17:61709145 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.15 -0.3 5.14e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7772486 0.686 rs9497395 chr6:146013592 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.67 -0.38 1.48e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg17178900 chr1:205818956 PM20D1 0.78 12.1 0.6 3.85e-27 Menarche (age at onset); CESC cis rs7246657 1.000 rs1823061 chr19:37800626 G/A cg23950597 chr19:37808831 NA -0.58 -6.21 -0.36 2.08e-9 Coronary artery calcification; CESC cis rs1371867 0.810 rs2919470 chr8:101233301 C/A cg11906718 chr8:101322791 RNF19A -0.49 -6.18 -0.36 2.36e-9 Atrioventricular conduction; CESC cis rs2777491 0.789 rs316617 chr15:41795900 C/T cg02330683 chr15:41787940 ITPKA -0.52 -7.55 -0.42 7.25e-13 Ulcerative colitis; CESC cis rs10129255 0.500 rs1974468 chr14:107142166 A/G cg23076370 chr14:107095027 NA -0.67 -10.15 -0.53 1.18e-20 Kawasaki disease; CESC cis rs9611565 0.921 rs5751081 chr22:41742788 A/T cg03806693 chr22:41940476 POLR3H -0.71 -8.47 -0.46 1.76e-15 Vitiligo; CESC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.68 -0.58 1.06e-25 Alzheimer's disease; CESC cis rs2635047 1.000 rs2684818 chr18:44712965 C/T cg19077165 chr18:44547161 KATNAL2 -0.43 -5.88 -0.34 1.22e-8 Educational attainment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02718464 chr13:41384019 SUGT1L1;SLC25A15;MIR621 -0.57 -6.1 -0.35 3.68e-9 Gut microbiome composition (summer); CESC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg23754390 chr11:835074 CD151 0.33 5.96 0.34 8.14e-9 Mean platelet volume; CESC trans rs561341 0.505 rs28708703 chr17:30386845 C/G cg20587970 chr11:113659929 NA -1.06 -12.78 -0.62 1.92e-29 Hip circumference adjusted for BMI; CESC cis rs1692580 0.870 rs262680 chr1:2167149 C/T cg04315214 chr1:2043799 PRKCZ -0.39 -5.82 -0.34 1.68e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03056341 chr11:64546100 SF1 0.65 7.64 0.42 4.08e-13 Gut microbiome composition (summer); CESC cis rs644799 0.965 rs545342 chr11:95545369 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3892630 0.588 rs8106748 chr19:33282797 G/A cg13157960 chr19:33183277 NUDT19 0.56 5.65 0.33 4.13e-8 Red blood cell traits; CESC cis rs1729951 0.575 rs35289288 chr3:136680568 C/T cg03617693 chr3:136751559 NA 0.38 5.31 0.31 2.3e-7 Neuroticism; CESC cis rs1153858 1.000 rs67461176 chr15:45676819 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs2952156 0.684 rs881844 chr17:37810218 C/G cg20243544 chr17:37824526 PNMT 0.67 8.99 0.48 4.65e-17 Asthma; CESC cis rs11098499 0.955 rs4145951 chr4:120155817 A/G cg09307838 chr4:120376055 NA 0.87 11.39 0.57 1.02e-24 Corneal astigmatism; CESC cis rs367943 0.635 rs2222144 chr5:112712208 G/T cg12552261 chr5:112820674 MCC 0.38 5.07 0.3 7.31e-7 Type 2 diabetes; CESC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg02725872 chr8:58115012 NA -0.42 -5.72 -0.33 2.88e-8 Developmental language disorder (linguistic errors); CESC trans rs163030 0.902 rs335600 chr5:76752546 A/C cg26150533 chr8:82396069 FABP4 -0.39 -6.06 -0.35 4.57e-9 Caudate nucleus volume; CESC cis rs9916302 0.904 rs11078897 chr17:37415870 C/T cg00129232 chr17:37814104 STARD3 -0.55 -7.11 -0.4 1.11e-11 Glomerular filtration rate (creatinine); CESC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg12963246 chr6:28129442 ZNF389 0.56 7.62 0.42 4.43e-13 Parkinson's disease; CESC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs8114671 0.527 rs2253484 chr20:33405263 A/T cg24642439 chr20:33292090 TP53INP2 -0.42 -5.04 -0.3 8.49e-7 Height; CESC cis rs936229 0.656 rs12898397 chr15:75130093 T/C cg14664628 chr15:75095509 CSK -0.59 -7.96 -0.44 5.14e-14 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs34375054 0.525 rs10846829 chr12:125595058 G/C cg25124228 chr12:125621409 AACS -0.57 -7.18 -0.4 7.17e-12 Post bronchodilator FEV1/FVC ratio; CESC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg10053473 chr17:62856997 LRRC37A3 0.65 7.33 0.41 2.74e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs28489187 0.706 rs2268667 chr1:85793746 A/G cg16011679 chr1:85725395 C1orf52 -0.53 -6.14 -0.35 3.05e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg14061069 chr19:46274453 DMPK 0.52 8.23 0.45 8.39e-15 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12112058 chr1:224622605 WDR26 0.47 6.1 0.35 3.75e-9 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18632102 chr5:154238496 CNOT8 -0.65 -7.19 -0.4 6.44e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03812994 chr10:81205453 ZCCHC24 -0.64 -7.14 -0.4 8.98e-12 Gut microbiome composition (summer); CESC cis rs4654899 0.714 rs12133972 chr1:21091338 A/T cg05370193 chr1:21551575 ECE1 0.34 5.05 0.3 8.26e-7 Superior frontal gyrus grey matter volume; CESC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.82 10.45 0.54 1.22e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg02297831 chr4:17616191 MED28 0.62 7.77 0.43 1.73e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs3780486 0.834 rs75443249 chr9:33149207 A/G cg20290983 chr6:43655470 MRPS18A 0.85 12.21 0.6 1.64e-27 IgG glycosylation; CESC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg22029157 chr1:209979665 IRF6 0.71 10.16 0.53 1.11e-20 Cleft lip with or without cleft palate; CESC trans rs11098499 0.863 rs13149407 chr4:120437825 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.5 0.5 1.34e-18 Corneal astigmatism; CESC cis rs9815354 0.812 rs766286 chr3:41838329 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg22535103 chr8:58192502 C8orf71 -0.94 -9.38 -0.5 2.99e-18 Developmental language disorder (linguistic errors); CESC cis rs1957429 0.808 rs4902325 chr14:65330843 A/G cg23373153 chr14:65346875 NA -0.87 -9.05 -0.49 3.09e-17 Pediatric areal bone mineral density (radius); CESC trans rs6951245 0.638 rs74976697 chr7:1160505 C/T cg13565492 chr6:43139072 SRF -0.61 -6.54 -0.37 3.24e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03650474 chr10:98592837 LCOR -0.49 -6.02 -0.35 5.79e-9 Ulcerative colitis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11886286 chr6:27114864 HIST1H2BK;HIST1H2AH 0.46 6.14 0.35 3.07e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1538970 1.000 rs2492840 chr1:45849792 C/A cg06784218 chr1:46089804 CCDC17 0.3 5.13 0.3 5.71e-7 Platelet count; CESC trans rs7615952 0.641 rs7618515 chr3:125790578 C/T cg07211511 chr3:129823064 LOC729375 -0.57 -6.39 -0.37 7.57e-10 Blood pressure (smoking interaction); CESC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg05368731 chr17:41323189 NBR1 0.77 10.06 0.53 2.31e-20 Menopause (age at onset); CESC cis rs2594989 0.943 rs2454499 chr3:11500531 T/C cg00170343 chr3:11313890 ATG7 0.56 5.1 0.3 6.55e-7 Circulating chemerin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02343720 chr2:241516354 RNPEPL1 -0.54 -6.51 -0.37 3.77e-10 Gut microbiome composition (summer); CESC cis rs870825 0.616 rs7683537 chr4:185631998 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.89 0.39 3.95e-11 Blood protein levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05890826 chr6:12008908 NA -0.54 -6.35 -0.36 9.29e-10 Ulcerative colitis; CESC cis rs754466 0.605 rs10824578 chr10:79578244 G/C cg17075019 chr10:79541650 NA -0.87 -14.42 -0.66 3.39e-35 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7264396 0.563 rs1970577 chr20:34336737 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.72 0.38 1.08e-10 Total cholesterol levels; CESC cis rs116095464 1.000 rs2015774 chr5:312958 G/T cg22857025 chr5:266934 NA -1.18 -10.37 -0.54 2.29e-21 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05970768 chr5:171682616 UBTD2 -0.67 -8.24 -0.45 8.05e-15 Gut microbiome composition (summer); CESC cis rs59918340 0.728 rs35257077 chr8:142235049 C/T cg23750338 chr8:142222470 SLC45A4 -0.6 -9.16 -0.49 1.48e-17 Immature fraction of reticulocytes; CESC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg04315214 chr1:2043799 PRKCZ -0.44 -7.26 -0.41 4.29e-12 Height; CESC cis rs67311347 1.000 rs7628247 chr3:40512682 G/T cg01475735 chr3:40494733 NA 0.41 5.17 0.3 4.71e-7 Renal cell carcinoma; CESC cis rs4803455 0.565 rs11670143 chr19:41864971 A/G cg08477640 chr19:41863820 B9D2 0.49 6.78 0.38 7.72e-11 Migraine;Coronary artery disease; CESC cis rs11871801 0.918 rs4633765 chr17:40682341 T/A cg21433558 chr17:40837037 CNTNAP1 -0.46 -5.3 -0.31 2.43e-7 Crohn's disease; CESC cis rs12545109 0.836 rs2196586 chr8:57347126 C/T cg09654669 chr8:57350985 NA 0.56 7.03 0.4 1.74e-11 Obesity-related traits; CESC cis rs4253772 0.550 rs6008729 chr22:46727428 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.59 -6.64 -0.38 1.81e-10 LDL cholesterol;Cholesterol, total; CESC cis rs1707322 1.000 rs7519181 chr1:46387829 G/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17253792 0.545 rs3742570 chr14:56016434 A/C cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC trans rs2235573 0.527 rs139865 chr22:38353932 C/G cg19894588 chr14:64061835 NA 0.59 7.85 0.43 1.04e-13 Glioblastoma;Glioma; CESC cis rs10949834 0.618 rs810551 chr7:73492093 C/G cg07137043 chr7:73588983 EIF4H -0.62 -7.33 -0.41 2.74e-12 Verbal memory performance (residualized delayed recall change); CESC cis rs2439831 0.850 rs56909447 chr15:44137618 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.46 0.42 1.21e-12 Lung cancer in ever smokers; CESC trans rs3942852 0.806 rs10734562 chr11:48128189 A/T cg03929089 chr4:120376271 NA 0.54 6.02 0.35 5.72e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs1348850 0.793 rs6734528 chr2:178493731 G/A cg22681709 chr2:178499509 PDE11A -0.43 -6.41 -0.37 6.61e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14329673 chr8:95732141 DPY19L4 0.6 6.73 0.38 1.03e-10 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14634336 chr6:111804804 REV3L -0.43 -6.01 -0.35 6.15e-9 Gambling; CESC cis rs7799006 0.755 rs2256545 chr7:2291943 G/A cg12823233 chr7:2316876 SNX8 -0.31 -5.17 -0.3 4.73e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs72781680 1.000 rs72796327 chr2:24140372 T/C cg20701182 chr2:24300061 SF3B14 0.7 6.16 0.35 2.65e-9 Lymphocyte counts; CESC cis rs4253772 0.513 rs6008612 chr22:46707907 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.78 9.13 0.49 1.85e-17 LDL cholesterol;Cholesterol, total; CESC cis rs6088580 0.634 rs6088471 chr20:32932643 C/A cg08999081 chr20:33150536 PIGU -0.65 -11.2 -0.57 4.14e-24 Glomerular filtration rate (creatinine); CESC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg22823121 chr1:150693482 HORMAD1 0.42 5.86 0.34 1.35e-8 Melanoma; CESC cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg25427524 chr10:38739819 LOC399744 -0.71 -10.41 -0.54 1.67e-21 Extrinsic epigenetic age acceleration; CESC cis rs4835473 0.830 rs7692672 chr4:144892201 C/T cg25736465 chr4:144833511 NA 0.39 6.0 0.35 6.45e-9 Immature fraction of reticulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27510503 chr22:22012035 NA 0.45 6.51 0.37 3.65e-10 Gut microbiota (bacterial taxa); CESC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg04944784 chr2:26401820 FAM59B -0.66 -7.62 -0.42 4.62e-13 Gut microbiome composition (summer); CESC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg04511125 chr2:88470314 THNSL2 0.68 6.68 0.38 1.44e-10 Plasma clusterin levels; CESC cis rs10208940 0.841 rs10172125 chr2:68787191 T/G cg12452813 chr2:68675892 NA 0.52 5.25 0.31 3.12e-7 Urate levels in lean individuals; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01143375 chr3:191670642 NA -0.45 -6.04 -0.35 5.24e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg25405998 chr7:65216604 CCT6P1 -0.46 -5.22 -0.31 3.71e-7 Aortic root size; CESC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg16049864 chr8:95962084 TP53INP1 -0.67 -12.02 -0.59 7.73e-27 Type 2 diabetes; CESC cis rs826838 0.933 rs1906263 chr12:38653362 T/C cg13010199 chr12:38710504 ALG10B 0.59 8.31 0.45 4.93e-15 Heart rate; CESC cis rs9300255 0.596 rs10773002 chr12:123746961 A/T cg19016782 chr12:123741754 C12orf65 0.38 5.76 0.33 2.27e-8 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16326998 chr7:5553266 FBXL18 0.6 6.53 0.37 3.29e-10 Gut microbiome composition (summer); CESC cis rs11148252 0.500 rs342768 chr13:53208882 C/T cg00495681 chr13:53174319 NA 0.53 7.38 0.41 2.02e-12 Lewy body disease; CESC cis rs4332037 0.538 rs4721164 chr7:1932629 C/G cg23422044 chr7:1970798 MAD1L1 -0.45 -5.89 -0.34 1.14e-8 Bipolar disorder; CESC cis rs67460515 0.563 rs13085336 chr3:160880599 G/A cg03342759 chr3:160939853 NMD3 -0.48 -6.27 -0.36 1.49e-9 Parkinson's disease; CESC cis rs3820068 0.603 rs998032 chr1:15989918 T/C cg17385448 chr1:15911702 AGMAT 0.44 7.29 0.41 3.48e-12 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14417711 chr11:6478126 TRIM3 -0.55 -6.0 -0.35 6.51e-9 Gut microbiome composition (summer); CESC cis rs1499614 1.000 rs1882655 chr7:66147057 T/C cg13147721 chr7:65941812 NA 0.96 9.03 0.49 3.53e-17 Gout; CESC cis rs11864453 0.826 rs2074627 chr16:72136769 C/T cg16558253 chr16:72132732 DHX38 -0.6 -9.43 -0.5 2.21e-18 Fibrinogen levels; CESC cis rs8062405 0.722 rs3785354 chr16:28550667 C/T cg07382826 chr16:28625726 SULT1A1 0.39 6.49 0.37 4.32e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs17401966 0.898 rs12117635 chr1:10317445 C/T cg15208524 chr1:10270712 KIF1B 0.41 5.31 0.31 2.36e-7 Hepatocellular carcinoma; CESC cis rs7116495 0.737 rs6592456 chr11:71737663 G/A cg07596299 chr11:71824057 C11orf51 -0.84 -5.06 -0.3 8e-7 Severe influenza A (H1N1) infection; CESC cis rs17376456 0.877 rs10476596 chr5:93367074 C/T cg25358565 chr5:93447407 FAM172A -1.13 -10.45 -0.54 1.29e-21 Diabetic retinopathy; CESC cis rs12477438 0.520 rs11678456 chr2:99708237 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 15.55 0.69 3.41e-39 Chronic sinus infection; CESC cis rs9905704 0.647 rs12944274 chr17:57041293 C/G cg12560992 chr17:57184187 TRIM37 -0.59 -7.45 -0.42 1.32e-12 Testicular germ cell tumor; CESC cis rs36051895 0.632 rs62541944 chr9:5159318 G/T cg02405213 chr9:5042618 JAK2 -0.52 -6.24 -0.36 1.71e-9 Pediatric autoimmune diseases; CESC cis rs7259376 0.902 rs10408428 chr19:22578023 G/T cg02657401 chr19:22469223 NA 0.26 5.14 0.3 5.27e-7 Menopause (age at onset); CESC cis rs1018836 0.669 rs6471243 chr8:91656967 C/T cg16814680 chr8:91681699 NA 0.94 17.21 0.73 4.63e-45 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs3733585 0.673 rs7378340 chr4:9955198 C/T cg00071950 chr4:10020882 SLC2A9 -0.7 -11.52 -0.58 3.62e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9487051 0.768 rs461487 chr6:109525504 A/G cg01475377 chr6:109611718 NA -0.46 -6.94 -0.39 2.94e-11 Reticulocyte fraction of red cells; CESC cis rs7084402 0.967 rs1649023 chr10:60285820 C/T cg07615347 chr10:60278583 BICC1 0.59 9.54 0.51 9.81e-19 Refractive error; CESC trans rs2727020 0.729 rs10839268 chr11:49380328 G/A cg03929089 chr4:120376271 NA -0.79 -11.94 -0.59 1.39e-26 Coronary artery disease; CESC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.29 0.57 2.21e-24 Alzheimer's disease; CESC cis rs4141404 0.816 rs5749227 chr22:31581166 A/G cg13145458 chr22:31556086 RNF185 0.55 5.84 0.34 1.49e-8 Paclitaxel-induced neuropathy; CESC cis rs2242116 0.796 rs4683296 chr3:46973820 G/C cg27129171 chr3:47204927 SETD2 -0.55 -7.04 -0.4 1.64e-11 Birth weight; CESC cis rs2637266 0.967 rs12246430 chr10:78352879 C/T cg18941641 chr10:78392320 NA 0.43 7.97 0.44 4.67e-14 Pulmonary function; CESC cis rs61931739 0.500 rs11053278 chr12:34555955 T/C cg06521331 chr12:34319734 NA -0.36 -5.03 -0.3 9.01e-7 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs10178094 0.669 rs7595982 chr2:161332385 T/G cg03641300 chr2:160917029 PLA2R1 -0.48 -6.32 -0.36 1.09e-9 White blood cell count; CESC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg05564831 chr3:52568323 NT5DC2 0.43 6.39 0.37 7.44e-10 Bipolar disorder; CESC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs6662572 0.906 rs11590549 chr1:46086329 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.43 5.19 0.3 4.1e-7 Blood protein levels; CESC cis rs7605827 0.897 rs11885852 chr2:15515371 A/C cg19274914 chr2:15703543 NA 0.31 5.39 0.31 1.55e-7 Educational attainment (years of education); CESC cis rs10411936 0.720 rs7252649 chr19:16582785 G/T cg10248733 chr19:16607483 C19orf44;CALR3 0.53 6.64 0.38 1.82e-10 White blood cell count;Multiple sclerosis; CESC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg14773178 chr5:1868261 NA 0.32 5.78 0.33 2.06e-8 Cardiovascular disease risk factors; CESC cis rs13102973 0.965 rs7656209 chr4:135875550 G/A cg14419869 chr4:135874104 NA 0.36 5.67 0.33 3.64e-8 Subjective well-being; CESC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg16606324 chr3:10149918 C3orf24 0.42 5.16 0.3 4.9e-7 Alzheimer's disease; CESC cis rs3785574 0.962 rs114027117 chr17:61939935 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.5 0.42 9.37e-13 Height; CESC cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4595586 0.545 rs7967931 chr12:39375162 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs863345 0.604 rs11264985 chr1:158465166 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC trans rs7618501 0.602 rs2240326 chr3:50128386 G/A cg21659725 chr3:3221576 CRBN -0.53 -7.36 -0.41 2.33e-12 Intelligence (multi-trait analysis); CESC cis rs2718058 0.519 rs2598047 chr7:37888488 G/T cg15028436 chr7:37888078 TXNDC3 0.5 7.26 0.41 4.24e-12 Alzheimer's disease (late onset); CESC cis rs9911578 1.000 rs1631237 chr17:56734695 A/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC trans rs208520 0.526 rs7775830 chr6:66755249 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 19.21 0.76 4.13e-52 Exhaled nitric oxide output; CESC cis rs10492096 0.947 rs10849483 chr12:6635374 G/A cg13857086 chr12:6580257 VAMP1 0.56 5.44 0.32 1.23e-7 Hip geometry; CESC cis rs7586879 1.000 rs10207698 chr2:25117672 C/T cg01884057 chr2:25150051 NA 0.28 5.1 0.3 6.54e-7 Body mass index; CESC cis rs73019876 0.720 rs1989118 chr19:22205679 A/G cg11619707 chr19:22235551 ZNF257 -0.27 -5.21 -0.3 3.75e-7 Testicular germ cell tumor; CESC cis rs9611565 0.546 rs34077262 chr22:42061639 A/G cg17376030 chr22:41985996 PMM1 -0.67 -7.63 -0.42 4.29e-13 Vitiligo; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04197904 chr22:46318272 WNT7B -0.4 -6.08 -0.35 4.15e-9 Ulcerative colitis; CESC cis rs7953249 0.656 rs6489786 chr12:121397875 A/G cg25281562 chr12:121454272 C12orf43 -0.46 -5.7 -0.33 3.12e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs34779708 0.966 rs12782948 chr10:35450607 G/A cg03585969 chr10:35415529 CREM 0.78 10.59 0.55 4.34e-22 Inflammatory bowel disease;Crohn's disease; CESC cis rs5769765 0.819 rs9616377 chr22:50310880 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.57 -5.99 -0.35 6.82e-9 Schizophrenia; CESC trans rs208515 0.525 rs4145045 chr6:66678949 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.9 0.56 4.24e-23 Exhaled nitric oxide levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01496715 chr11:252450 PSMD13 0.47 6.48 0.37 4.41e-10 Fibrinogen levels; CESC cis rs9660992 0.649 rs12128229 chr1:205268014 C/A cg21643547 chr1:205240462 TMCC2 -0.47 -6.19 -0.36 2.23e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg18876405 chr7:65276391 NA 0.69 9.57 0.51 8.21e-19 Calcium levels; CESC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg22823121 chr1:150693482 HORMAD1 0.46 6.33 0.36 1.07e-9 Melanoma; CESC trans rs4824093 0.610 rs3761496 chr22:50246466 T/C cg09872104 chr7:134855509 C7orf49 -0.95 -6.67 -0.38 1.52e-10 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9911578 0.967 rs3826353 chr17:57075299 C/T cg05425664 chr17:57184151 TRIM37 -0.52 -7.26 -0.41 4.28e-12 Intelligence (multi-trait analysis); CESC cis rs12410462 0.581 rs75219436 chr1:227546617 C/T cg04117972 chr1:227635322 NA 0.62 5.31 0.31 2.27e-7 Major depressive disorder; CESC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg00166722 chr3:10149974 C3orf24 0.47 5.97 0.34 7.77e-9 Alzheimer's disease; CESC cis rs7107174 1.000 rs2373009 chr11:77945815 T/A cg02023728 chr11:77925099 USP35 0.55 6.86 0.39 4.93e-11 Testicular germ cell tumor; CESC cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg14820908 chr5:178986412 RUFY1 0.44 6.16 0.35 2.69e-9 Lung cancer; CESC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs5769765 1.000 rs5769760 chr22:50259696 A/G cg02269571 chr22:50332266 NA 0.46 6.25 0.36 1.62e-9 Schizophrenia; CESC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg22590775 chr19:49891494 CCDC155 0.62 7.31 0.41 3.16e-12 Multiple sclerosis; CESC cis rs67311347 1.000 rs9332450 chr3:40458041 C/T cg09455208 chr3:40491958 NA -0.44 -7.45 -0.42 1.36e-12 Renal cell carcinoma; CESC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg24549020 chr5:56110836 MAP3K1 0.68 7.56 0.42 6.74e-13 Initial pursuit acceleration; CESC cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg10523679 chr1:76189770 ACADM 0.66 7.01 0.4 1.92e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg07960162 chr16:68577389 ZFP90 0.42 6.17 0.35 2.61e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs7922314 0.571 rs61865723 chr10:64757951 T/A cg06935979 chr1:232941706 KIAA1383 -0.64 -6.14 -0.35 2.95e-9 Cutaneous psoriasis; CESC cis rs637571 0.512 rs660118 chr11:65735174 G/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.7 9.7 0.51 3.1400000000000002e-19 Eosinophil percentage of white cells; CESC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg06873352 chr17:61820015 STRADA 0.73 12.89 0.62 7.87e-30 Prudent dietary pattern; CESC cis rs1003719 0.680 rs7276569 chr21:38578207 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.58e-15 Eye color traits; CESC cis rs9287719 0.934 rs6432115 chr2:10748343 G/T cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs17125944 0.505 rs3783447 chr14:53191647 G/A cg00686598 chr14:53173677 PSMC6 1.33 11.24 0.57 3.2e-24 Alzheimer's disease (late onset); CESC trans rs1814175 0.616 rs10839388 chr11:49842603 C/T cg03929089 chr4:120376271 NA -0.87 -13.78 -0.65 6.24e-33 Height; CESC cis rs55794721 0.509 rs12027110 chr1:25775682 A/T cg27572855 chr1:25598939 RHD 0.49 8.32 0.46 4.54e-15 Plateletcrit;Mean corpuscular volume; CESC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg27266060 chr8:22091797 NA -0.38 -7.76 -0.43 1.87e-13 Hypertriglyceridemia; CESC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.2 -0.36 2.21e-9 Parkinson's disease; CESC cis rs8014204 0.967 rs1319171 chr14:75334096 G/T cg11812906 chr14:75593930 NEK9 -0.41 -5.1 -0.3 6.63e-7 Caffeine consumption; CESC cis rs2635047 0.682 rs4534948 chr18:44793419 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.09 0.3 6.89e-7 Educational attainment; CESC cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10089 0.953 rs10463839 chr5:127519675 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 9.49 0.5 1.37e-18 Ileal carcinoids; CESC cis rs9512730 0.527 rs11619784 chr13:27999643 A/G cg08193333 chr13:27998609 GTF3A 0.55 6.39 0.37 7.3e-10 Schizophrenia; CESC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg22442454 chr1:209979470 IRF6 0.47 5.65 0.33 4.13e-8 Cleft lip with or without cleft palate; CESC trans rs629535 0.814 rs674429 chr8:70069942 G/A cg21567404 chr3:27674614 NA 0.88 10.34 0.54 2.74e-21 Dupuytren's disease; CESC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg22029157 chr1:209979665 IRF6 0.49 7.64 0.43 3.88e-13 Monobrow; CESC cis rs116988415 0.584 rs4902310 chr14:65241906 T/C cg25083366 chr14:65239357 SPTB 0.69 5.03 0.3 8.89e-7 Daytime sleep phenotypes; CESC cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs3820928 1.000 rs4675115 chr2:227769123 C/G cg11843606 chr2:227700838 RHBDD1 -0.4 -5.2 -0.3 3.93e-7 Pulmonary function; CESC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg22800045 chr5:56110881 MAP3K1 0.82 10.05 0.53 2.45e-20 Initial pursuit acceleration; CESC cis rs7208859 0.673 rs60020217 chr17:29185054 G/A cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg10883421 chr6:151773342 RMND1;C6orf211 0.86 14.48 0.66 2.19e-35 Menarche (age at onset); CESC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg24296786 chr1:45957014 TESK2 0.63 8.21 0.45 9.97e-15 High light scatter reticulocyte count; CESC cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg05347473 chr6:146136440 FBXO30 0.58 7.43 0.42 1.48e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs3106136 0.967 rs13132963 chr4:95219780 A/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.87 -0.39 4.53e-11 Capecitabine sensitivity; CESC cis rs2282802 0.685 rs12717951 chr5:139589309 A/G cg26211634 chr5:139558579 C5orf32 0.49 7.23 0.41 5.22e-12 Intelligence (multi-trait analysis); CESC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg10896456 chr17:42255109 ASB16;C17orf65 0.44 6.52 0.37 3.58e-10 Total body bone mineral density; CESC cis rs709400 0.770 rs7142883 chr14:104066645 G/A cg12935359 chr14:103987150 CKB -0.47 -5.96 -0.34 8.22e-9 Body mass index; CESC cis rs7927771 0.896 rs12794570 chr11:47658314 C/T cg05585544 chr11:47624801 NA -0.53 -8.35 -0.46 3.82e-15 Subjective well-being; CESC cis rs4523957 0.583 rs7503141 chr17:2044645 T/C cg16513277 chr17:2031491 SMG6 -0.79 -11.73 -0.58 6.95e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7149337 0.809 rs10134478 chr14:51693708 G/C cg23942311 chr14:51606299 NA 0.46 7.57 0.42 6.3e-13 Cancer; CESC cis rs2629540 0.889 rs10901815 chr10:126435598 G/A cg08799069 chr10:126477246 METTL10 -0.66 -9.2 -0.49 1.13e-17 Cocaine dependence; CESC cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7914558 0.966 rs10883817 chr10:104755431 C/T cg08650961 chr10:104748594 CNNM2 0.34 5.7 0.33 3.21e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg11764359 chr7:65958608 NA -0.67 -8.64 -0.47 5.38e-16 Aortic root size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24179850 chr19:56154938 ZNF581 -0.46 -6.23 -0.36 1.85e-9 Ulcerative colitis; CESC cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg20476274 chr7:133979776 SLC35B4 0.67 9.79 0.52 1.65e-19 Mean platelet volume; CESC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.91e-8 Lung cancer; CESC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg19717773 chr7:2847554 GNA12 -0.47 -6.67 -0.38 1.51e-10 Height; CESC cis rs7246657 0.943 rs10414904 chr19:37830088 G/A cg23950597 chr19:37808831 NA -0.55 -6.09 -0.35 3.96e-9 Coronary artery calcification; CESC cis rs9768139 1.000 rs9768139 chr7:158120731 G/A cg06219351 chr7:158114137 PTPRN2 0.48 7.48 0.42 1.09e-12 Calcium levels; CESC cis rs2204008 0.774 rs7959048 chr12:37948276 T/A cg26384229 chr12:38710491 ALG10B 0.71 10.61 0.55 3.71e-22 Bladder cancer; CESC cis rs5753618 0.555 rs9609304 chr22:31897795 T/C cg00478049 chr22:31556069 RNF185 -0.44 -5.17 -0.3 4.68e-7 Colorectal cancer; CESC cis rs9487051 0.652 rs13210424 chr6:109598737 G/A cg12927641 chr6:109611667 NA -0.37 -5.52 -0.32 7.95e-8 Reticulocyte fraction of red cells; CESC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg23034840 chr1:205782522 SLC41A1 0.6 6.83 0.39 5.92e-11 Menarche (age at onset); CESC cis rs950169 0.614 rs12903883 chr15:84680553 A/G cg17507749 chr15:85114479 UBE2QP1 0.61 6.14 0.35 3.05e-9 Schizophrenia; CESC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg07701084 chr6:150067640 NUP43 0.43 5.71 0.33 2.97e-8 Lung cancer; CESC cis rs1008375 0.966 rs4235389 chr4:17696280 A/G cg15017067 chr4:17643749 FAM184B 0.35 5.15 0.3 5.11e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs7618501 0.602 rs6780731 chr3:50017478 A/G cg21659725 chr3:3221576 CRBN 0.54 7.51 0.42 9.17e-13 Intelligence (multi-trait analysis); CESC cis rs2075371 0.863 rs1421479 chr7:133949345 T/G cg20476274 chr7:133979776 SLC35B4 0.62 8.89 0.48 9.92e-17 Mean platelet volume; CESC cis rs4835473 0.897 rs924234 chr4:144627952 C/A cg25736465 chr4:144833511 NA 0.39 5.94 0.34 8.8e-9 Immature fraction of reticulocytes; CESC cis rs7914558 1.000 rs4917996 chr10:104925829 A/C cg15744005 chr10:104629667 AS3MT -0.31 -5.04 -0.3 8.62e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg10053473 chr17:62856997 LRRC37A3 -0.72 -7.88 -0.44 8.47e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1564271 0.528 rs2209350 chr10:26987779 A/G cg13837822 chr10:26931731 LOC731789 0.43 6.75 0.38 9.17e-11 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CESC cis rs9815354 0.812 rs73071208 chr3:41978738 A/T cg03022575 chr3:42003672 ULK4 0.67 5.95 0.34 8.63e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs2070488 0.775 rs2051213 chr3:38560254 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.8 12.93 0.62 5.64e-30 Electrocardiographic conduction measures; CESC cis rs3749237 0.576 rs4241406 chr3:49600426 C/T cg02487422 chr3:49467188 NICN1 0.58 8.48 0.46 1.56e-15 Resting heart rate; CESC cis rs10924309 0.889 rs10802248 chr1:245858554 A/C cg00036263 chr1:245852353 KIF26B -0.4 -5.05 -0.3 8.1e-7 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs9916302 0.904 rs11078910 chr17:37671269 G/T cg00129232 chr17:37814104 STARD3 -0.54 -7.09 -0.4 1.19e-11 Glomerular filtration rate (creatinine); CESC cis rs4728302 0.838 rs10225454 chr7:133591535 G/C cg10665199 chr7:133106180 EXOC4 0.39 5.39 0.31 1.55e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg04025307 chr7:1156635 C7orf50 0.41 6.51 0.37 3.77e-10 Longevity;Endometriosis; CESC cis rs7914558 0.966 rs7096269 chr10:104736721 A/G cg08650961 chr10:104748594 CNNM2 0.32 5.11 0.3 6.16e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs3740540 0.507 rs10794161 chr10:126291327 C/A cg04949429 chr10:126290192 LHPP 0.4 5.61 0.33 5.04e-8 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs2832191 1.000 rs9984793 chr21:30486471 T/C cg24692254 chr21:30365293 RNF160 -0.73 -10.87 -0.56 5.11e-23 Dental caries; CESC cis rs3857067 1.000 rs899134 chr4:95019675 C/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs864745 0.600 rs849335 chr7:28223990 T/C cg23620719 chr7:28220237 JAZF1 -0.44 -5.2 -0.3 3.91e-7 Crohn's disease;Type 2 diabetes; CESC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg12463550 chr7:65579703 CRCP -0.51 -6.48 -0.37 4.51e-10 Aortic root size; CESC cis rs3105593 1.000 rs2011064 chr15:50957625 C/G cg08437265 chr15:50716283 USP8 0.43 5.64 0.33 4.35e-8 QT interval; CESC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.14 -0.3 5.22e-7 Lung cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17823829 chr1:202765754 KDM5B 0.46 6.88 0.39 4.33e-11 Gut microbiota (bacterial taxa); CESC cis rs10492096 1.000 rs11064210 chr12:6576721 C/T cg13857086 chr12:6580257 VAMP1 0.64 6.69 0.38 1.33e-10 Hip geometry; CESC trans rs1728785 0.901 rs821169 chr16:68630184 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 7.69 0.43 2.91e-13 Ulcerative colitis; CESC cis rs6499255 0.951 rs1437136 chr16:69672675 G/C cg15192750 chr16:69999425 NA 0.5 5.77 0.33 2.19e-8 IgE levels; CESC cis rs9309473 0.539 rs6745560 chr2:73827117 C/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.84 -0.39 5.52e-11 Metabolite levels; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg20317272 chr18:60383672 PHLPP1 -0.45 -6.1 -0.35 3.64e-9 Recombination measurement; CESC cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg20476274 chr7:133979776 SLC35B4 0.66 9.8 0.52 1.5e-19 Mean platelet volume; CESC trans rs11098499 0.954 rs11935596 chr4:120412457 G/C cg25214090 chr10:38739885 LOC399744 0.72 10.08 0.53 1.97e-20 Corneal astigmatism; CESC cis rs6693567 0.565 rs11205373 chr1:150404708 A/G cg09579323 chr1:150459698 TARS2 0.46 5.97 0.34 7.46e-9 Migraine; CESC cis rs9457247 0.967 rs1590257 chr6:167377782 G/T cg25258033 chr6:167368657 RNASET2 -0.42 -6.25 -0.36 1.63e-9 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26201011 chr10:101874558 NA -0.55 -6.79 -0.38 7.31e-11 Gut microbiome composition (summer); CESC cis rs72945132 0.882 rs7122057 chr11:70201430 T/C cg00319359 chr11:70116639 PPFIA1 0.72 6.98 0.39 2.33e-11 Coronary artery disease; CESC cis rs4835473 0.897 rs35515006 chr4:144655858 T/A cg25736465 chr4:144833511 NA -0.33 -5.22 -0.31 3.68e-7 Immature fraction of reticulocytes; CESC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg18301423 chr5:131593218 PDLIM4 0.38 5.38 0.31 1.61e-7 Breast cancer; CESC cis rs1355223 0.902 rs286861 chr11:34718424 A/T cg11058730 chr11:34937778 PDHX;APIP -0.51 -6.89 -0.39 4.1e-11 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs5758659 0.569 rs133293 chr22:42382797 G/A cg15557168 chr22:42548783 NA -0.44 -6.34 -0.36 9.58e-10 Cognitive function; CESC cis rs72781680 0.821 rs72796369 chr2:24162663 G/T cg08917208 chr2:24149416 ATAD2B 0.63 6.24 0.36 1.73e-9 Lymphocyte counts; CESC cis rs694739 0.595 rs11542299 chr11:64138805 T/C cg02228329 chr11:64053129 BAD;GPR137 0.61 7.51 0.42 9.02e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs9905704 0.709 rs758378 chr17:56607746 G/C cg12560992 chr17:57184187 TRIM37 -0.6 -6.28 -0.36 1.36e-9 Testicular germ cell tumor; CESC trans rs875971 1.000 rs778699 chr7:65868290 G/A cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.77e-9 Aortic root size; CESC cis rs5769765 0.955 rs9616366 chr22:50301178 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.49 -5.53 -0.32 7.82e-8 Schizophrenia; CESC cis rs1707322 1.000 rs11211232 chr1:46411146 C/T cg06784218 chr1:46089804 CCDC17 0.35 5.96 0.34 8.17e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg22535103 chr8:58192502 C8orf71 -0.95 -10.54 -0.54 6.39e-22 Developmental language disorder (linguistic errors); CESC cis rs7834588 0.526 rs9298070 chr8:63870658 A/C cg20602954 chr8:63776762 NKAIN3 -0.33 -5.26 -0.31 2.98e-7 Response to Vitamin E supplementation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12931157 chr6:41040265 C6orf130;NFYA 0.59 7.06 0.4 1.43e-11 Gut microbiome composition (summer); CESC cis rs5769765 0.908 rs138864 chr22:50204712 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.48 -5.48 -0.32 9.95e-8 Schizophrenia; CESC cis rs12142240 0.698 rs17357683 chr1:46815378 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs6570726 0.935 rs392014 chr6:145843691 A/C cg05347473 chr6:146136440 FBXO30 0.43 5.83 0.34 1.58e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs6674176 0.628 rs3828146 chr1:44428715 C/T cg13606994 chr1:44402422 ARTN -0.37 -5.58 -0.32 6.03e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs561341 0.556 rs542244 chr17:30307242 T/C cg20587970 chr11:113659929 NA -1.41 -18.1 -0.74 3.08e-48 Hip circumference adjusted for BMI; CESC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg04546413 chr19:29218101 NA 0.56 7.77 0.43 1.76e-13 Methadone dose in opioid dependence; CESC cis rs78456975 0.506 rs13384333 chr2:1555531 A/C cg26248373 chr2:1572462 NA -0.58 -6.89 -0.39 3.97e-11 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs35955747 0.902 rs12167361 chr22:31696278 G/C cg25791279 chr22:32026902 PISD -0.49 -5.86 -0.34 1.38e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.38 5.04 0.3 8.73e-7 Menopause (age at onset); CESC cis rs4332037 0.950 rs10267593 chr7:1937261 G/A cg23422044 chr7:1970798 MAD1L1 -0.57 -6.89 -0.39 3.99e-11 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20706599 chr15:90777202 CIB1;C15orf58 -0.46 -6.52 -0.37 3.52e-10 Fibrinogen levels; CESC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 11.29 0.57 2.15e-24 Platelet count; CESC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg25985355 chr7:65971099 NA 0.32 5.27 0.31 2.86e-7 Aortic root size; CESC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.59 -7.67 -0.43 3.19e-13 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19973604 chr17:73914282 FBF1 0.44 6.32 0.36 1.12e-9 Fibrinogen levels; CESC cis rs7512552 0.839 rs11205357 chr1:150267798 T/C cg15654264 chr1:150340011 RPRD2 -0.41 -5.32 -0.31 2.19e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC trans rs7980799 0.935 rs7294492 chr12:33548530 C/T cg26384229 chr12:38710491 ALG10B -0.49 -6.74 -0.38 9.61e-11 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs6502050 0.835 rs7501527 chr17:80099355 A/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.22 -0.36 1.88e-9 Life satisfaction; CESC trans rs4716602 0.596 rs10266659 chr7:156159278 A/G cg07175507 chr18:77160758 NFATC1 -0.44 -6.08 -0.35 4.18e-9 Anti-saccade response; CESC cis rs8020095 0.571 rs8009087 chr14:67564210 C/T cg19548862 chr14:67692701 FAM71D 0.5 6.35 0.36 9.13e-10 Depression (quantitative trait); CESC cis rs4888262 0.526 rs6564145 chr16:74621129 G/A cg01733217 chr16:74700730 RFWD3 0.85 11.41 0.57 8.81e-25 Testicular germ cell tumor; CESC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg03188948 chr7:1209495 NA 0.66 7.35 0.41 2.45e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2425143 0.730 rs7263640 chr20:34314725 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -7.53 -0.42 7.76e-13 Blood protein levels; CESC trans rs10506458 1.000 rs10506458 chr12:63445092 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.32 -17.48 -0.73 4.95e-46 Hemostatic factors and hematological phenotypes; CESC cis rs11166927 0.703 rs2126127 chr8:140788362 G/A cg16909799 chr8:140841666 TRAPPC9 0.48 6.7 0.38 1.26e-10 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg16606324 chr3:10149918 C3orf24 -0.4 -5.09 -0.3 6.66e-7 Alzheimer's disease; CESC cis rs909002 0.745 rs4949458 chr1:32142332 G/T cg13919466 chr1:32135498 COL16A1 0.35 5.9 0.34 1.12e-8 Intelligence (multi-trait analysis); CESC cis rs651907 0.557 rs12629954 chr3:101360623 C/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.82 0.34 1.73e-8 Colorectal cancer; CESC cis rs858239 0.539 rs10279194 chr7:23191083 T/C cg23682824 chr7:23144976 KLHL7 0.51 6.77 0.38 8.05e-11 Cerebrospinal fluid biomarker levels; CESC cis rs9309473 0.797 rs6723247 chr2:73846749 A/G cg20560298 chr2:73613845 ALMS1 -0.43 -5.74 -0.33 2.55e-8 Metabolite levels; CESC cis rs34779708 0.966 rs998658 chr10:35408654 A/G cg03585969 chr10:35415529 CREM 0.79 10.48 0.54 1.04e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs2282802 0.685 rs62385161 chr5:139635747 T/C cg26211634 chr5:139558579 C5orf32 0.52 7.65 0.43 3.74e-13 Intelligence (multi-trait analysis); CESC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg07507251 chr3:52567010 NT5DC2 0.35 5.94 0.34 8.88e-9 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14588896 chr20:2505177 NA 0.56 6.13 0.35 3.16e-9 Gut microbiome composition (summer); CESC cis rs62408225 1.000 rs2875584 chr6:90950628 C/T cg06866423 chr6:90926672 BACH2 0.5 6.11 0.35 3.52e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9486715 0.867 rs9372106 chr6:96875058 T/C cg18709589 chr6:96969512 KIAA0776 0.46 6.63 0.38 1.88e-10 Headache; CESC cis rs7666738 0.546 rs28444809 chr4:98916934 C/T cg17366294 chr4:99064904 C4orf37 0.47 5.66 0.33 3.94e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.86e-17 Tonsillectomy; CESC cis rs7264396 0.733 rs2425105 chr20:34312834 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.83 -0.59 3.3e-26 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27079446 chr18:3449844 TGIF1 0.54 6.71 0.38 1.17e-10 Gut microbiome composition (summer); CESC cis rs228437 0.913 rs4896078 chr6:134910571 A/T cg24504307 chr6:134963096 NA 0.49 5.79 0.33 2.03e-8 Melanoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09850442 chr2:25896287 DTNB 0.57 6.37 0.36 8.37e-10 Gut microbiome composition (summer); CESC cis rs4561483 0.603 rs11075033 chr16:12006338 C/T cg08843971 chr16:11963173 GSPT1 0.46 6.45 0.37 5.14e-10 Testicular germ cell tumor; CESC cis rs5747327 0.874 rs5746451 chr22:18126020 T/C cg19898043 chr22:18121309 BCL2L13 -0.45 -5.62 -0.33 4.77e-8 Myeloid white cell count;Granulocyte count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12277888 chr11:35723985 TRIM44 -0.5 -6.93 -0.39 3.17e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7542091 0.704 rs7537294 chr1:210043777 A/G cg25204440 chr1:209979598 IRF6 0.37 5.1 0.3 6.55e-7 Monobrow; CESC cis rs1799949 0.965 rs799912 chr17:41257134 T/C cg25072359 chr17:41440525 NA 0.49 7.48 0.42 1.12e-12 Menopause (age at onset); CESC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg07648498 chr16:89883185 FANCA 0.47 5.85 0.34 1.44e-8 Vitiligo; CESC cis rs55871839 0.643 rs7004274 chr8:59810378 T/A cg07426533 chr8:59803705 TOX -0.44 -6.39 -0.37 7.37e-10 Pneumonia; CESC cis rs7914558 0.966 rs2065977 chr10:104729415 C/T cg04362960 chr10:104952993 NT5C2 0.45 5.76 0.33 2.33e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2408955 0.521 rs11168437 chr12:48566156 C/T cg24011408 chr12:48396354 COL2A1 0.49 7.23 0.41 5.3e-12 Glycated hemoglobin levels; CESC cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg07636037 chr3:49044803 WDR6 1.03 19.55 0.77 2.54e-53 Parkinson's disease; CESC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg22920501 chr2:26401640 FAM59B 0.86 9.99 0.52 3.79e-20 Gut microbiome composition (summer); CESC cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg23711669 chr6:146136114 FBXO30 1.01 15.49 0.69 5.86e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs11155671 0.530 rs7774787 chr6:150209432 G/A cg09699651 chr6:150184138 LRP11 0.56 7.76 0.43 1.81e-13 Testicular germ cell tumor; CESC cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg21138405 chr5:131827807 IRF1 0.54 9.24 0.49 8.12e-18 Asthma (sex interaction); CESC cis rs2075371 0.611 rs1862045 chr7:134023412 A/G cg20476274 chr7:133979776 SLC35B4 0.54 7.26 0.41 4.38e-12 Mean platelet volume; CESC cis rs7103648 0.897 rs11606287 chr11:47407439 C/A cg03711944 chr11:47377212 SPI1 -0.36 -5.74 -0.33 2.62e-8 Diastolic blood pressure;Systolic blood pressure; CESC cis rs703842 1.000 rs10783848 chr12:58196528 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.69 8.87 0.48 1.09e-16 Multiple sclerosis; CESC cis rs12824058 0.831 rs7485200 chr12:130811641 C/T cg23887609 chr12:130822674 PIWIL1 0.47 6.01 0.35 6.22e-9 Menopause (age at onset); CESC cis rs2228479 0.850 rs11648433 chr16:89965055 G/A cg04013166 chr16:89971882 TCF25 0.75 6.27 0.36 1.47e-9 Skin colour saturation; CESC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg17143192 chr8:8559678 CLDN23 0.71 8.24 0.45 8.06e-15 Obesity-related traits; CESC cis rs6987853 0.527 rs3935700 chr8:42364121 T/C cg09913449 chr8:42400586 C8orf40 -0.36 -5.66 -0.33 3.99e-8 Mean corpuscular hemoglobin concentration; CESC cis rs992157 0.764 rs13020391 chr2:219184436 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.57 -7.3 -0.41 3.26e-12 Colorectal cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04309227 chr1:26561027 CCDC21 0.51 6.75 0.38 9.38e-11 Systemic lupus erythematosus; CESC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.37 -0.31 1.76e-7 Life satisfaction; CESC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 10.35 0.54 2.68e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13116174 chr6:80816309 BCKDHB 0.59 6.26 0.36 1.56e-9 Gut microbiome composition (summer); CESC cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg05564831 chr3:52568323 NT5DC2 0.41 5.43 0.32 1.25e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06545038 chr1:201868886 LMOD1 -0.57 -6.12 -0.35 3.4e-9 Gut microbiome composition (summer); CESC cis rs4654899 1.000 rs3767248 chr1:21276854 A/G cg05370193 chr1:21551575 ECE1 0.39 5.83 0.34 1.61e-8 Superior frontal gyrus grey matter volume; CESC cis rs6088580 0.634 rs2184836 chr20:32963369 A/G cg08999081 chr20:33150536 PIGU -0.66 -11.72 -0.58 8.03e-26 Glomerular filtration rate (creatinine); CESC cis rs7584330 0.737 rs12465714 chr2:238365637 C/T cg14458575 chr2:238380390 NA 0.62 8.39 0.46 3.03e-15 Prostate cancer; CESC cis rs3733585 0.699 rs7658170 chr4:9966593 C/T cg11266682 chr4:10021025 SLC2A9 0.57 10.68 0.55 2.24e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs57502260 0.704 rs12286536 chr11:68290234 C/G cg20283391 chr11:68216788 NA -0.65 -5.45 -0.32 1.12e-7 Total body bone mineral density (age 45-60); CESC cis rs8180040 1.000 rs2159400 chr3:47375890 T/C cg27129171 chr3:47204927 SETD2 -0.69 -10.73 -0.55 1.5e-22 Colorectal cancer; CESC cis rs3749237 1.000 rs1317140 chr3:49878652 G/A cg03060546 chr3:49711283 APEH 0.59 6.73 0.38 1.07e-10 Resting heart rate; CESC cis rs7267979 1.000 rs6050566 chr20:25351071 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.5 -0.71 1.44e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs5753037 0.809 rs713657 chr22:30211876 A/G cg01021169 chr22:30184971 ASCC2 -0.39 -5.1 -0.3 6.39e-7 Type 1 diabetes; CESC cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg10523679 chr1:76189770 ACADM 0.79 10.7 0.55 1.91e-22 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg18301423 chr5:131593218 PDLIM4 0.39 5.49 0.32 9.57e-8 Breast cancer; CESC cis rs6087990 1.000 rs6087990 chr20:31349908 T/C cg13636640 chr20:31349939 DNMT3B 0.93 17.19 0.73 5.14e-45 Ulcerative colitis; CESC cis rs7584330 0.554 rs7587496 chr2:238387632 A/G cg14458575 chr2:238380390 NA 0.72 6.09 0.35 3.86e-9 Prostate cancer; CESC cis rs7503807 1.000 rs7503807 chr17:78591111 G/T cg09596252 chr17:78655493 RPTOR -0.47 -6.93 -0.39 3.17e-11 Obesity; CESC cis rs1775715 0.870 rs1775735 chr10:32255846 A/G cg18675610 chr10:32216311 ARHGAP12 0.33 5.14 0.3 5.37e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07617175 chr5:99871683 FAM174A -0.54 -6.25 -0.36 1.64e-9 Gut microbiome composition (summer); CESC cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg07697082 chr8:82753677 SNX16 0.39 6.08 0.35 4.26e-9 Diastolic blood pressure; CESC trans rs55704346 0.534 rs6814162 chr4:25389501 A/G cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs2072499 0.750 rs57056972 chr1:156159064 C/A cg25208724 chr1:156163844 SLC25A44 1.01 12.84 0.62 1.13e-29 Testicular germ cell tumor; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg09397319 chr2:64250606 NA 0.41 6.27 0.36 1.46e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs62458065 0.713 rs921406 chr7:32486205 G/C cg20159608 chr7:32802032 NA -0.53 -5.08 -0.3 7.29e-7 Metabolite levels (HVA/MHPG ratio); CESC cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg20503657 chr10:835505 NA 0.8 8.24 0.45 7.81e-15 Eosinophil percentage of granulocytes; CESC cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.37 5.84 0.34 1.56e-8 Monocyte percentage of white cells; CESC cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg25427524 chr10:38739819 LOC399744 -0.67 -9.72 -0.51 2.65e-19 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21881364 chr11:72438004 ARAP1 -0.6 -6.6 -0.38 2.25e-10 Gut microbiome composition (summer); CESC cis rs460214 0.553 rs9976546 chr21:40028193 C/G cg05519781 chr21:40033154 ERG -0.44 -5.45 -0.32 1.17e-7 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs4664304 0.714 rs66496937 chr2:160738509 A/G cg03641300 chr2:160917029 PLA2R1 -0.41 -5.34 -0.31 1.97e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs11098499 0.863 rs3775845 chr4:120432447 T/C cg09307838 chr4:120376055 NA 0.94 12.8 0.62 1.53e-29 Corneal astigmatism; CESC cis rs854765 0.623 rs9893690 chr17:17753846 A/T cg16928487 chr17:17741425 SREBF1 0.58 10.45 0.54 1.28e-21 Total body bone mineral density; CESC cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg22834771 chr12:69754056 YEATS4 -0.48 -6.46 -0.37 4.87e-10 Blood protein levels; CESC cis rs12971120 0.783 rs7229256 chr18:72169129 T/A cg25817165 chr18:72167213 CNDP2 -0.56 -7.72 -0.43 2.31e-13 Refractive error; CESC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg07701084 chr6:150067640 NUP43 0.46 5.96 0.34 8.16e-9 Lung cancer; CESC cis rs727505 0.721 rs67817822 chr7:124769572 A/G cg23710748 chr7:124431027 NA -0.37 -6.18 -0.35 2.43e-9 Lewy body disease; CESC cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.63 7.67 0.43 3.39e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs1267303 0.675 rs1267308 chr1:46987718 A/G cg25110126 chr1:46999211 NA -0.92 -9.91 -0.52 6.55e-20 Monobrow; CESC cis rs9303401 0.625 rs34963822 chr17:56988424 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.31 0.6 7.4e-28 Cognitive test performance; CESC trans rs5417 0.689 rs55868524 chr17:7170665 G/A cg15655154 chr3:113604241 GRAMD1C -0.51 -6.8 -0.39 6.96e-11 Diastolic blood pressure; CESC cis rs826838 0.935 rs11169547 chr12:39185625 C/A cg13010199 chr12:38710504 ALG10B 0.58 8.05 0.44 2.77e-14 Heart rate; CESC cis rs4144027 0.935 rs10139856 chr14:104354505 T/C cg08213375 chr14:104286397 PPP1R13B -0.29 -5.03 -0.3 8.94e-7 Blood metabolite levels; CESC cis rs9309473 0.898 rs10197755 chr2:73797623 T/A cg20560298 chr2:73613845 ALMS1 -0.54 -7.03 -0.4 1.7e-11 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25922239 chr6:33757077 LEMD2 -0.6 -6.54 -0.37 3.2e-10 Gut microbiome composition (summer); CESC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg16325326 chr1:53192061 ZYG11B 0.89 14.42 0.66 3.56e-35 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16357477 chr17:79633857 C17orf90;CCDC137 0.66 7.7 0.43 2.67e-13 Gut microbiome composition (summer); CESC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg15369054 chr17:80825471 TBCD -0.36 -5.12 -0.3 5.81e-7 Breast cancer; CESC cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 5.97e-17 Prostate cancer (SNP x SNP interaction); CESC trans rs2832077 0.527 rs11088095 chr21:30223188 A/T cg14791747 chr16:20752902 THUMPD1 0.53 7.48 0.42 1.12e-12 Cognitive test performance; CESC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg24829409 chr8:58192753 C8orf71 -0.7 -7.82 -0.43 1.29e-13 Developmental language disorder (linguistic errors); CESC cis rs6061231 0.793 rs2427320 chr20:60976723 A/G cg22633769 chr20:60982531 CABLES2 0.5 5.05 0.3 8.42e-7 Colorectal cancer; CESC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.69 -0.33 3.38e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg04944784 chr2:26401820 FAM59B -0.65 -7.41 -0.41 1.7e-12 Gut microbiome composition (summer); CESC cis rs72615157 0.539 rs72615159 chr7:99674286 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.41 5.05 0.3 8.06e-7 Lung function (FEV1/FVC); CESC cis rs11122272 0.735 rs2024878 chr1:231528415 A/C cg06096015 chr1:231504339 EGLN1 -0.39 -5.72 -0.33 2.86e-8 Hemoglobin concentration; CESC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg07747251 chr5:1868357 NA 0.33 5.46 0.32 1.08e-7 Cardiovascular disease risk factors; CESC cis rs2228479 0.557 rs57071566 chr16:89889327 T/G cg14709524 chr16:89940631 TCF25 0.84 6.02 0.35 5.74e-9 Skin colour saturation; CESC cis rs113835537 0.529 rs11227495 chr11:66263243 C/T cg24851651 chr11:66362959 CCS 0.42 5.2 0.3 3.91e-7 Airway imaging phenotypes; CESC cis rs2479724 0.755 rs4318867 chr6:41753670 G/T cg08135965 chr6:41755394 TOMM6 -0.4 -5.25 -0.31 3.19e-7 Menarche (age at onset); CESC cis rs1006703 0.544 rs7220897 chr17:3837643 A/G cg06463185 chr17:3833770 ATP2A3 -0.55 -5.91 -0.34 1.05e-8 Glucose homeostasis traits; CESC cis rs6541297 0.703 rs678578 chr1:230320600 G/A cg20703242 chr1:230279135 GALNT2 -0.41 -5.38 -0.31 1.65e-7 Coronary artery disease; CESC trans rs3780486 0.846 rs2209948 chr9:33138247 G/A cg20290983 chr6:43655470 MRPS18A 0.99 17.84 0.74 2.65e-47 IgG glycosylation; CESC cis rs854765 0.547 rs2955356 chr17:17964717 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.54 -7.02 -0.4 1.86e-11 Total body bone mineral density; CESC cis rs7546094 1.000 rs3013440 chr1:113195789 G/A cg22162597 chr1:113214053 CAPZA1 -0.39 -6.01 -0.35 6.17e-9 Platelet distribution width; CESC cis rs4906332 1.000 rs2065017 chr14:103879579 T/C cg09975044 chr14:104007538 NA 0.46 6.34 0.36 9.68e-10 Coronary artery disease; CESC cis rs634534 0.591 rs688862 chr11:65733393 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.45 5.5 0.32 9.11e-8 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg11742103 chr11:62369870 EML3;MTA2 -0.55 -8.27 -0.45 6.36e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs6964587 1.000 rs2157747 chr7:91750578 A/G cg17063962 chr7:91808500 NA 0.57 7.87 0.44 9.34e-14 Breast cancer; CESC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg17949981 chr6:28129498 ZNF389 0.46 5.76 0.33 2.3e-8 Depression; CESC cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg17366294 chr4:99064904 C4orf37 0.57 7.92 0.44 6.7e-14 Colonoscopy-negative controls vs population controls; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04360491 chr11:47600569 NDUFS3;KBTBD4 0.51 6.71 0.38 1.17e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4803468 1.000 rs10413735 chr19:41921071 C/T cg09537434 chr19:41945824 ATP5SL -1.11 -20.39 -0.78 3.11e-56 Height; CESC cis rs763121 0.889 rs6001209 chr22:39121252 C/T cg06022373 chr22:39101656 GTPBP1 -0.82 -11.98 -0.59 1.02e-26 Menopause (age at onset); CESC trans rs1814175 0.817 rs11518158 chr11:49985633 G/T cg03929089 chr4:120376271 NA -0.93 -15.76 -0.7 6.39e-40 Height; CESC cis rs10791097 0.694 rs4370948 chr11:130755700 A/C cg09137382 chr11:130731461 NA 0.37 5.48 0.32 9.83e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg05313129 chr8:58192883 C8orf71 -0.54 -6.27 -0.36 1.47e-9 Developmental language disorder (linguistic errors); CESC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg18230493 chr5:56204884 C5orf35 -0.72 -8.5 -0.46 1.41e-15 Type 2 diabetes; CESC trans rs1814175 0.591 rs11040589 chr11:49862449 A/G cg15704280 chr7:45808275 SEPT13 -1.0 -18.78 -0.76 1.35e-50 Height; CESC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg12419862 chr22:24373484 LOC391322 -0.71 -10.05 -0.53 2.42e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg24399712 chr22:39784796 NA 0.79 10.93 0.56 3.24e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg24308560 chr3:49941425 MST1R -0.56 -7.83 -0.43 1.21e-13 Body mass index; CESC trans rs4942242 0.659 rs1105586 chr13:44232633 C/T cg19169023 chr15:41853346 TYRO3 0.54 7.36 0.41 2.28e-12 Response to tocilizumab in rheumatoid arthritis; CESC cis rs13095912 1.000 rs34965813 chr3:185333012 T/C cg11274856 chr3:185301563 NA 0.35 5.66 0.33 3.93e-8 Systolic blood pressure; CESC cis rs748404 0.534 rs489509 chr15:43586907 T/A cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.4 0.46 2.82e-15 Lung cancer; CESC cis rs9814567 0.929 rs9838834 chr3:134207077 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.41 -5.66 -0.33 3.95e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.13 -0.4 9.42e-12 Personality dimensions; CESC cis rs35110281 0.805 rs162402 chr21:44963418 G/C cg01579765 chr21:45077557 HSF2BP -0.57 -9.82 -0.52 1.31e-19 Mean corpuscular volume; CESC trans rs11098499 0.954 rs10006877 chr4:120242793 C/T cg25214090 chr10:38739885 LOC399744 0.69 9.63 0.51 5.18e-19 Corneal astigmatism; CESC cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg19717773 chr7:2847554 GNA12 -0.51 -7.26 -0.41 4.26e-12 Height; CESC cis rs2790457 0.958 rs2532742 chr10:28867220 C/G cg04045419 chr10:28823091 WAC -0.42 -5.04 -0.3 8.49e-7 Multiple myeloma; CESC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg26314531 chr2:26401878 FAM59B -0.82 -8.88 -0.48 1.07e-16 Gut microbiome composition (summer); CESC cis rs660498 0.507 rs2020155 chr10:27740194 C/T cg08398567 chr10:27609333 NA 0.38 5.18 0.3 4.5e-7 Asthma (childhood onset); CESC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg06456125 chr7:65229604 NA -0.4 -5.16 -0.3 4.88e-7 Aortic root size; CESC cis rs6741892 0.536 rs6761563 chr2:38891406 A/T cg00359181 chr2:38893519 GALM -0.64 -9.09 -0.49 2.43e-17 5-HTT brain serotonin transporter levels; CESC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg12463550 chr7:65579703 CRCP -0.48 -6.01 -0.35 6.25e-9 Aortic root size; CESC cis rs2075371 0.644 rs1643041 chr7:134012211 C/T cg00033643 chr7:134001901 SLC35B4 0.42 5.16 0.3 4.74e-7 Mean platelet volume; CESC cis rs763014 0.898 rs916416 chr16:632198 T/A cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC cis rs1003719 0.788 rs59637309 chr21:38475398 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs7605827 0.930 rs10168299 chr2:15615063 A/G cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04774194 chr6:127664674 ECHDC1 0.62 7.26 0.41 4.31e-12 Gut microbiome composition (summer); CESC cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg17366294 chr4:99064904 C4orf37 0.6 7.63 0.42 4.3e-13 Colonoscopy-negative controls vs population controls; CESC cis rs9303401 0.661 rs9902820 chr17:56637545 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.52 6.8 0.39 6.98e-11 Cognitive test performance; CESC cis rs2050392 0.630 rs303428 chr10:30739058 C/T cg25182066 chr10:30743637 MAP3K8 0.43 5.92 0.34 9.88e-9 Inflammatory bowel disease; CESC cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg08109568 chr15:31115862 NA -0.71 -9.43 -0.5 2.19e-18 Huntington's disease progression; CESC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg19099843 chr7:12443191 VWDE -0.5 -5.26 -0.31 2.97e-7 Coronary artery disease; CESC cis rs8040855 0.627 rs11632658 chr15:85606213 C/T cg08123816 chr15:85640762 PDE8A 0.4 5.94 0.34 8.98e-9 Bulimia nervosa; CESC trans rs9467711 0.606 rs9379851 chr6:26354780 A/C cg06606381 chr12:133084897 FBRSL1 -0.78 -7.22 -0.41 5.4e-12 Autism spectrum disorder or schizophrenia; CESC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg15445000 chr17:37608096 MED1 -0.41 -6.74 -0.38 9.82e-11 Glomerular filtration rate (creatinine); CESC cis rs6963495 0.818 rs1355614 chr7:105179176 A/G cg19920283 chr7:105172520 RINT1 0.71 8.05 0.44 2.89e-14 Bipolar disorder (body mass index interaction); CESC cis rs9399135 0.527 rs61738492 chr6:135282771 G/A cg24558204 chr6:135376177 HBS1L 0.7 9.47 0.5 1.6e-18 Red blood cell count; CESC cis rs7656342 0.686 rs1401440 chr4:9832512 C/T cg00071950 chr4:10020882 SLC2A9 0.41 5.54 0.32 7.34e-8 Gut microbiota (bacterial taxa); CESC cis rs897984 0.572 rs112906665 chr16:31040139 T/C cg02466173 chr16:30829666 NA -0.39 -6.68 -0.38 1.43e-10 Dementia with Lewy bodies; CESC cis rs965469 1.000 rs6051827 chr20:3372007 C/T cg25506879 chr20:3388711 C20orf194 -0.57 -6.12 -0.35 3.38e-9 IFN-related cytopenia; CESC cis rs735860 0.718 rs209488 chr6:53177540 A/T cg10236188 chr6:53219634 NA 0.35 5.23 0.31 3.43e-7 Glaucoma; CESC cis rs6062302 0.534 rs1556456 chr20:62216289 T/C cg09650180 chr20:62225654 GMEB2 -0.79 -8.81 -0.48 1.7e-16 Glioblastoma; CESC cis rs262150 0.659 rs2527237 chr7:158798494 A/G cg09640425 chr7:158790006 NA 0.37 5.67 0.33 3.64e-8 Facial morphology (factor 20); CESC cis rs9611565 0.592 rs1811113 chr22:42073134 C/T cg06481639 chr22:41940642 POLR3H 0.57 5.74 0.33 2.58e-8 Vitiligo; CESC cis rs933688 0.938 rs10063683 chr5:90714595 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 14.23 0.66 1.63e-34 Smoking behavior; CESC cis rs7916697 0.593 rs10762198 chr10:70023053 A/G cg06988349 chr10:69991859 ATOH7 -0.32 -5.18 -0.3 4.34e-7 Optic disc area; CESC trans rs1814175 0.645 rs10444311 chr11:49986906 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs11098499 0.535 rs10005542 chr4:120268302 T/C cg09307838 chr4:120376055 NA 0.76 10.03 0.52 2.87e-20 Corneal astigmatism; CESC cis rs12477438 0.765 rs6740054 chr2:99576631 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -8.88 -0.48 1.01e-16 Chronic sinus infection; CESC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg11301795 chr4:187892539 NA -0.75 -12.3 -0.6 8.03e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs1448094 0.791 rs10863114 chr12:86332325 T/C cg02569458 chr12:86230093 RASSF9 0.46 6.54 0.37 3.19e-10 Major depressive disorder; CESC cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1594829 0.553 rs17055108 chr8:26160739 G/A cg11498726 chr8:26250323 BNIP3L -0.4 -6.06 -0.35 4.68e-9 Height; CESC cis rs7267979 0.873 rs6132822 chr20:25228695 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.72 11.88 0.59 2.28e-26 Liver enzyme levels (alkaline phosphatase); CESC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg10295955 chr4:187884368 NA -1.05 -19.34 -0.77 1.43e-52 Lobe attachment (rater-scored or self-reported); CESC cis rs4604732 0.504 rs4634945 chr1:247636015 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.38 -5.92 -0.34 9.68e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs9975691 1 rs9975691 chr21:14928355 G/T cg18786515 chr8:10207915 MSRA -0.5 -6.3 -0.36 1.24e-9 Neurofibrillary tangles; CESC cis rs8067354 0.872 rs7224006 chr17:57896338 C/T cg13753209 chr17:57696993 CLTC -0.52 -7.03 -0.4 1.71e-11 Hemoglobin concentration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14817024 chr10:70939976 SUPV3L1 -0.44 -6.09 -0.35 4e-9 Gambling; CESC trans rs74054849 0.850 rs72878883 chr1:16012493 C/A cg06826283 chr7:600452 PRKAR1B 0.7 6.25 0.36 1.66e-9 Alcoholic chronic pancreatitis; CESC cis rs4803468 1.000 rs9304593 chr19:41942875 A/C cg14132834 chr19:41945861 ATP5SL 0.6 7.54 0.42 7.5e-13 Height; CESC cis rs7660520 0.557 rs76004373 chr4:183731011 C/G cg12524338 chr4:183729343 NA 0.54 5.19 0.3 4.28e-7 Pediatric autoimmune diseases; CESC cis rs6088580 0.634 rs13041646 chr20:33082881 T/A cg08999081 chr20:33150536 PIGU 0.66 11.62 0.58 1.7e-25 Glomerular filtration rate (creatinine); CESC cis rs644799 0.965 rs687529 chr11:95545587 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9790314 1.000 rs336569 chr3:161072346 T/G cg04691961 chr3:161091175 C3orf57 -0.4 -5.29 -0.31 2.52e-7 Morning vs. evening chronotype; CESC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg02725872 chr8:58115012 NA -0.45 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg18180107 chr4:99064573 C4orf37 -0.4 -5.18 -0.3 4.33e-7 Colonoscopy-negative controls vs population controls; CESC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg01341218 chr17:43662625 NA 0.51 6.64 0.38 1.81e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9916302 0.904 rs8076546 chr17:37555403 G/A cg15445000 chr17:37608096 MED1 -0.39 -6.44 -0.37 5.69e-10 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2742417 0.603 rs2742372 chr3:45783472 T/C cg04837898 chr3:45731254 SACM1L -0.46 -6.04 -0.35 5.16e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg06636001 chr8:8085503 FLJ10661 0.58 8.02 0.44 3.5e-14 Mood instability; CESC cis rs2243480 0.908 rs55876148 chr7:65379800 G/A cg13147721 chr7:65941812 NA -0.88 -8.15 -0.45 1.47e-14 Diabetic kidney disease; CESC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg11859384 chr17:80120422 CCDC57 0.38 5.08 0.3 7.27e-7 Life satisfaction; CESC cis rs6582630 0.537 rs1949611 chr12:38373092 C/T cg13010199 chr12:38710504 ALG10B -0.44 -5.66 -0.33 3.94e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs17401966 1.000 rs58053556 chr1:10442903 A/G cg15208524 chr1:10270712 KIF1B 0.49 6.15 0.35 2.87e-9 Hepatocellular carcinoma; CESC cis rs71277158 0.688 rs76336713 chr3:169911957 G/T cg04067573 chr3:169899625 PHC3 0.67 6.4 0.37 7.18e-10 Prostate cancer; CESC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg21248554 chr2:27665150 KRTCAP3 -0.32 -6.38 -0.36 7.82e-10 Total body bone mineral density; CESC cis rs798554 0.616 rs1636251 chr7:2884720 T/C cg19717773 chr7:2847554 GNA12 -0.49 -7.43 -0.42 1.5e-12 Height; CESC cis rs10861342 1.000 rs11112374 chr12:105510285 G/T cg23923672 chr12:105501055 KIAA1033 0.67 5.46 0.32 1.1e-7 IgG glycosylation; CESC cis rs7927771 0.524 rs7114813 chr11:47801101 A/G cg20307385 chr11:47447363 PSMC3 0.61 8.64 0.47 5.45e-16 Subjective well-being; CESC cis rs6582630 0.512 rs11182667 chr12:38588392 C/A cg26384229 chr12:38710491 ALG10B -0.42 -5.55 -0.32 7e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs60871478 1.000 rs7795258 chr7:795227 A/G cg27478167 chr7:817139 HEATR2 -0.49 -5.84 -0.34 1.48e-8 Cerebrospinal P-tau181p levels; CESC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs7539624 0.588 rs10916598 chr1:223895559 G/A cg10100437 chr1:223903862 CAPN2 0.42 5.5 0.32 9.02e-8 Schizophrenia; CESC cis rs933688 1.000 rs1035477 chr5:90743325 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 11.04 0.56 1.47e-23 Smoking behavior; CESC cis rs6541297 0.757 rs2760537 chr1:230326412 C/T cg20703242 chr1:230279135 GALNT2 -0.4 -5.32 -0.31 2.26e-7 Coronary artery disease; CESC cis rs425277 0.959 rs77665022 chr1:2065958 C/T cg23803603 chr1:2058230 PRKCZ 0.33 5.07 0.3 7.41e-7 Height; CESC cis rs909674 0.690 rs5750823 chr22:39829973 C/T cg01416388 chr22:39784598 NA -0.55 -7.04 -0.4 1.67e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1401999 1.000 rs10937158 chr3:183708439 T/C cg01324343 chr3:183735012 ABCC5 0.64 13.58 0.64 3.13e-32 Anterior chamber depth; CESC cis rs643506 0.874 rs640651 chr11:111728911 A/G cg17089665 chr11:111648010 NA -0.37 -5.49 -0.32 9.27e-8 Breast cancer; CESC cis rs6460942 0.591 rs7800823 chr7:12378697 G/T cg06484146 chr7:12443880 VWDE -0.41 -6.25 -0.36 1.67e-9 Coronary artery disease; CESC cis rs6963495 0.592 rs114793754 chr7:105152162 G/C cg19920283 chr7:105172520 RINT1 0.67 6.36 0.36 8.79e-10 Bipolar disorder (body mass index interaction); CESC cis rs2425143 1.000 rs2425093 chr20:34306875 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.65 -0.55 2.79e-22 Blood protein levels; CESC cis rs2180341 0.855 rs9385422 chr6:127716457 C/T cg27446573 chr6:127587934 RNF146 0.83 11.88 0.59 2.22e-26 Breast cancer; CESC cis rs8051149 0.688 rs16943320 chr16:87870379 A/G cg01829163 chr16:87871160 SLC7A5 -0.55 -6.84 -0.39 5.44e-11 Blood metabolite levels; CESC cis rs2075371 0.829 rs1993058 chr7:133930361 G/A cg11752832 chr7:134001865 SLC35B4 0.53 6.87 0.39 4.5e-11 Mean platelet volume; CESC cis rs9814567 1.000 rs9884031 chr3:134256500 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.15 -0.35 2.87e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs62064224 0.589 rs756785 chr17:30812845 T/C cg18200150 chr17:30822561 MYO1D 0.41 5.27 0.31 2.83e-7 Schizophrenia; CESC cis rs9549260 0.709 rs9549247 chr13:41220777 G/C cg21288729 chr13:41239152 FOXO1 0.67 8.72 0.47 3.11e-16 Red blood cell count; CESC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg04369109 chr6:150039330 LATS1 -0.42 -5.95 -0.34 8.52e-9 Lung cancer; CESC cis rs16854884 0.657 rs4611822 chr3:143735544 C/T cg06585982 chr3:143692056 C3orf58 0.5 6.56 0.37 2.84e-10 Economic and political preferences (feminism/equality); CESC cis rs10242455 1.000 rs17161692 chr7:98953863 A/G cg05403484 chr7:98973169 ARPC1B 0.6 5.47 0.32 1.07e-7 Blood metabolite levels; CESC cis rs11098499 0.909 rs10002083 chr4:120311152 C/T cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg12193833 chr17:30244370 NA -0.75 -6.94 -0.39 3.07e-11 Hip circumference adjusted for BMI; CESC cis rs35110281 0.632 rs9306160 chr21:45107562 T/C cg21573476 chr21:45109991 RRP1B -0.57 -8.15 -0.45 1.49e-14 Mean corpuscular volume; CESC cis rs6831352 0.879 rs1984362 chr4:100070973 G/A cg13256891 chr4:100009986 ADH5 -0.76 -8.02 -0.44 3.44e-14 Alcohol dependence; CESC cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg10556349 chr10:835070 NA 0.72 6.21 0.36 2.06e-9 Eosinophil percentage of granulocytes; CESC cis rs950169 0.800 rs4099846 chr15:84956894 C/G cg17507749 chr15:85114479 UBE2QP1 0.59 6.54 0.37 3.11e-10 Schizophrenia; CESC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg03188948 chr7:1209495 NA 0.73 7.17 0.4 7.66e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC cis rs12142240 0.667 rs55887761 chr1:46826587 C/A cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs9560113 0.509 rs4773390 chr13:112208904 G/A cg10483660 chr13:112241077 NA 0.43 7.19 0.4 6.66e-12 Menarche (age at onset); CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg22143856 chr6:28129313 ZNF389 0.5 6.59 0.38 2.34e-10 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23237418 chr14:23790594 PABPN1 -0.59 -6.95 -0.39 2.76e-11 Gut microbiome composition (summer); CESC cis rs919433 1.000 rs112572902 chr2:198175179 G/C cg10820045 chr2:198174542 NA -0.44 -6.93 -0.39 3.21e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs741677 0.702 rs9893847 chr17:489043 C/G cg15660573 chr17:549704 VPS53 -0.42 -5.46 -0.32 1.09e-7 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); CESC cis rs765787 0.530 rs1648287 chr15:45516956 T/C cg24006582 chr15:45444508 DUOX1 -0.53 -6.64 -0.38 1.75e-10 Uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04558166 chr1:210001279 C1orf107 0.51 6.05 0.35 4.85e-9 Gut microbiome composition (summer); CESC cis rs7914558 0.966 rs10786719 chr10:104637992 C/T cg15744005 chr10:104629667 AS3MT 0.33 5.09 0.3 6.72e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs722599 0.683 rs7160852 chr14:75239424 T/C cg11812906 chr14:75593930 NEK9 0.48 5.8 0.34 1.92e-8 IgG glycosylation; CESC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.07e-8 Lung cancer; CESC trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg03929089 chr4:120376271 NA 0.78 11.69 0.58 1e-25 Coronary artery disease; CESC trans rs17685 0.753 rs6953665 chr7:75769049 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 12.41 0.61 3.51e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs7552167 0.925 rs3932666 chr1:24511566 G/A cg01960748 chr1:24522592 NA -0.42 -5.25 -0.31 3.09e-7 Psoriasis vulgaris; CESC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg25072359 chr17:41440525 NA 0.5 6.77 0.38 8.41e-11 Menopause (age at onset); CESC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg07092213 chr7:1199455 ZFAND2A -0.45 -5.2 -0.3 3.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17825070 chr15:79614659 TMED3 -0.5 -6.03 -0.35 5.59e-9 Gut microbiome composition (summer); CESC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg04553112 chr3:125709451 NA -0.5 -5.61 -0.33 5e-8 Blood pressure (smoking interaction); CESC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg25405998 chr7:65216604 CCT6P1 -0.49 -5.24 -0.31 3.28e-7 Aortic root size; CESC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 5.62 0.33 4.72e-8 Menopause (age at onset); CESC cis rs2180341 0.804 rs6902233 chr6:127555963 A/G cg27446573 chr6:127587934 RNF146 0.96 11.81 0.59 3.97e-26 Breast cancer; CESC cis rs634534 0.622 rs552130 chr11:65732800 T/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.63 8.73 0.47 2.85e-16 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs2243480 1.000 rs160652 chr7:65538431 A/G cg12463550 chr7:65579703 CRCP 0.67 5.1 0.3 6.38e-7 Diabetic kidney disease; CESC cis rs1670533 1.000 rs676561 chr4:1083112 C/T cg27284194 chr4:1044797 NA 0.48 6.07 0.35 4.52e-9 Recombination rate (females); CESC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg25838465 chr1:92012736 NA -0.61 -8.93 -0.48 7.5e-17 Breast cancer; CESC cis rs9910055 0.550 rs113844752 chr17:42297631 C/A cg09913183 chr17:42254507 C17orf65;ASB16 0.42 5.06 0.3 7.72e-7 Total body bone mineral density; CESC cis rs7647973 0.626 rs1586827 chr3:49671224 T/C cg07636037 chr3:49044803 WDR6 0.53 6.3 0.36 1.22e-9 Menarche (age at onset); CESC cis rs1215050 0.660 rs3864229 chr4:98714323 A/G cg05340658 chr4:99064831 C4orf37 0.47 5.27 0.31 2.81e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9443645 1.000 rs9443645 chr6:79822924 C/T cg05283184 chr6:79620031 NA -0.38 -5.84 -0.34 1.54e-8 Intelligence (multi-trait analysis); CESC trans rs1268083 0.546 rs9398785 chr6:126057748 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.56 -7.56 -0.42 6.58e-13 Migraine; CESC cis rs72772090 0.634 rs17401901 chr5:96091925 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -5.58 -0.32 5.79e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs5769765 0.837 rs8142737 chr22:50291889 T/C cg26441486 chr22:50317300 CRELD2 0.39 5.39 0.31 1.56e-7 Schizophrenia; CESC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 12.99 0.62 3.48e-30 Platelet count; CESC cis rs7084402 0.967 rs1649057 chr10:60318114 C/T cg07615347 chr10:60278583 BICC1 0.64 10.18 0.53 9.13e-21 Refractive error; CESC cis rs9900497 0.783 rs758426 chr17:19620624 A/T cg27231068 chr17:19620291 SLC47A2 -0.37 -5.14 -0.3 5.43e-7 Response to paliperidone in schizophrenia (CGI-S score); CESC cis rs9457247 0.663 rs2237274 chr6:167442995 C/G cg07741184 chr6:167504864 NA 0.33 5.77 0.33 2.18e-8 Crohn's disease; CESC cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg12386194 chr3:101231763 SENP7 0.57 6.56 0.37 2.81e-10 Colonoscopy-negative controls vs population controls; CESC cis rs6439153 0.967 rs12695512 chr3:128722082 T/G cg24203234 chr3:128598194 ACAD9 0.4 5.29 0.31 2.56e-7 Pneumococcal bacteremia; CESC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg11764359 chr7:65958608 NA -0.53 -6.98 -0.39 2.34e-11 Aortic root size; CESC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg23281280 chr6:28129359 ZNF389 0.37 5.47 0.32 1.06e-7 Parkinson's disease; CESC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg00484396 chr16:3507460 NAT15 0.57 7.32 0.41 2.94e-12 Tuberculosis; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg00297737 chr8:97273749 MTERFD1;PTDSS1 0.49 6.43 0.37 5.82e-10 Thyroid stimulating hormone; CESC cis rs8044868 0.512 rs4788461 chr16:72156000 C/A cg16558253 chr16:72132732 DHX38 -0.38 -5.9 -0.34 1.1e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs6580649 0.941 rs11612970 chr12:48451009 T/C cg05342945 chr12:48394962 COL2A1 0.5 5.85 0.34 1.47e-8 Lung cancer; CESC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg05313129 chr8:58192883 C8orf71 -0.56 -6.38 -0.37 7.65e-10 Developmental language disorder (linguistic errors); CESC cis rs12477438 0.501 rs11683188 chr2:99724512 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 12.8 0.62 1.54e-29 Chronic sinus infection; CESC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg15445000 chr17:37608096 MED1 -0.4 -6.61 -0.38 2.1e-10 Glomerular filtration rate (creatinine); CESC cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg27347728 chr4:17578864 LAP3 0.43 5.12 0.3 5.92e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs61869271 0.871 rs12098332 chr10:116728074 A/T cg23260525 chr10:116636907 FAM160B1 0.29 5.07 0.3 7.41e-7 Tonsillectomy; CESC cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg25019033 chr10:957182 NA -0.56 -6.07 -0.35 4.4e-9 Eosinophil percentage of granulocytes; CESC cis rs763121 0.853 rs6519124 chr22:39045099 T/C cg06544989 chr22:39130855 UNC84B 0.5 9.27 0.49 6.78e-18 Menopause (age at onset); CESC cis rs11792861 0.926 rs7855282 chr9:111802614 T/A cg14384093 chr9:111878565 C9orf5 -0.42 -5.18 -0.3 4.36e-7 Menarche (age at onset); CESC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg05564831 chr3:52568323 NT5DC2 0.45 6.91 0.39 3.55e-11 Bipolar disorder; CESC cis rs9549367 0.707 rs9549353 chr13:113843427 G/A cg18105134 chr13:113819100 PROZ -0.7 -8.26 -0.45 6.89e-15 Platelet distribution width; CESC cis rs61996546 0.622 rs56031087 chr15:26847834 A/C cg14859324 chr15:26874363 GABRB3 -0.37 -5.06 -0.3 7.97e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs5769765 0.955 rs8135816 chr22:50291976 G/C cg02269571 chr22:50332266 NA -0.45 -6.05 -0.35 4.98e-9 Schizophrenia; CESC cis rs8077889 0.750 rs231533 chr17:41945588 A/G cg26893861 chr17:41843967 DUSP3 -0.79 -7.63 -0.42 4.21e-13 Triglycerides; CESC cis rs2295359 0.892 rs11209005 chr1:67618678 A/G cg17031739 chr1:67600172 NA 0.39 5.2 0.3 3.91e-7 Psoriasis; CESC cis rs30380 1.000 rs30379 chr5:96122260 T/G cg16492584 chr5:96139282 ERAP1 -0.35 -5.35 -0.31 1.89e-7 Cerebrospinal fluid biomarker levels; CESC cis rs425277 0.916 rs414777 chr1:2101687 G/A cg24578937 chr1:2090814 PRKCZ 0.55 9.62 0.51 5.7e-19 Height; CESC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg17971929 chr21:40555470 PSMG1 1.05 15.94 0.7 1.48e-40 Cognitive function; CESC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg24562669 chr7:97807699 LMTK2 0.49 7.18 0.4 7.18e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg22903471 chr2:27725779 GCKR -0.58 -8.33 -0.46 4.42e-15 Total body bone mineral density; CESC cis rs10752881 1.000 rs4454510 chr1:182982303 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.82 -12.84 -0.62 1.14e-29 Colorectal cancer; CESC trans rs9467711 0.606 rs2073527 chr6:26374978 T/C cg06606381 chr12:133084897 FBRSL1 -0.77 -6.78 -0.38 7.69e-11 Autism spectrum disorder or schizophrenia; CESC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg03351412 chr1:154909251 PMVK 0.67 9.01 0.48 4.07e-17 Prostate cancer; CESC cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg25517755 chr10:38738941 LOC399744 -0.49 -6.36 -0.36 8.84e-10 Extrinsic epigenetic age acceleration; CESC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg24879335 chr3:133465180 TF 0.37 6.5 0.37 3.93e-10 Iron status biomarkers; CESC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg24733560 chr20:60626293 TAF4 0.45 6.44 0.37 5.45e-10 Body mass index; CESC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 13.23 0.63 4.99e-31 Platelet count; CESC cis rs9837602 0.529 rs1087198 chr3:99524381 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.52 -6.21 -0.36 2.05e-9 Breast cancer; CESC cis rs12079745 0.623 rs115415855 chr1:169322993 G/A cg09363564 chr1:169337483 NME7;BLZF1 -1.18 -6.79 -0.39 7.13e-11 QT interval; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15272186 chr6:29709610 LOC285830 -0.44 -6.5 -0.37 3.86e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4727027 0.901 rs1137432 chr7:148801658 C/T cg23583168 chr7:148888333 NA -0.78 -11.97 -0.59 1.14e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs55823223 0.648 rs936394 chr17:73852008 C/A cg06969265 chr17:73775802 H3F3B 0.63 6.82 0.39 6.03e-11 Psoriasis; CESC trans rs11039798 0.614 rs116427493 chr11:48776141 C/T cg15704280 chr7:45808275 SEPT13 0.72 6.56 0.37 2.79e-10 Axial length; CESC cis rs6540556 0.723 rs9430016 chr1:209916884 A/G cg05527609 chr1:210001259 C1orf107 -0.45 -5.59 -0.32 5.66e-8 Red blood cell count; CESC cis rs67311347 1.000 rs12488805 chr3:40422869 C/T cg24209194 chr3:40518798 ZNF619 0.5 6.05 0.35 4.91e-9 Renal cell carcinoma; CESC cis rs7580658 0.637 rs12463909 chr2:127971738 C/G cg10021288 chr2:128175891 PROC 0.33 5.07 0.3 7.31e-7 Protein C levels; CESC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.6 0.33 5.33e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2742234 0.541 rs10793424 chr10:43717116 G/T cg07801480 chr10:43725741 RASGEF1A -0.4 -5.24 -0.31 3.22e-7 Hirschsprung disease; CESC cis rs367943 0.712 rs9326884 chr5:112697520 C/A cg12552261 chr5:112820674 MCC 0.43 5.58 0.32 6.06e-8 Type 2 diabetes; CESC cis rs2228479 0.618 rs62052174 chr16:89950901 G/A cg00800038 chr16:89945340 TCF25 -0.88 -7.85 -0.43 1.01e-13 Skin colour saturation; CESC cis rs3008870 0.629 rs12742428 chr1:67426487 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.63 8.34 0.46 4.16e-15 Lymphocyte percentage of white cells; CESC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.07 -0.35 4.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs992157 0.710 rs13026485 chr2:219057984 C/T cg00012203 chr2:219082015 ARPC2 -0.83 -11.41 -0.57 8.64e-25 Colorectal cancer; CESC cis rs7264396 0.635 rs6058366 chr20:34512172 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.58 7.06 0.4 1.44e-11 Total cholesterol levels; CESC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg23978390 chr7:1156363 C7orf50 0.62 8.9 0.48 9.25e-17 Longevity;Endometriosis; CESC cis rs116095464 0.614 rs78905930 chr5:246560 G/A cg20965017 chr5:231967 SDHA -0.47 -5.23 -0.31 3.53e-7 Breast cancer; CESC cis rs9549367 0.789 rs71446679 chr13:113894821 C/T cg00898013 chr13:113819073 PROZ -0.51 -6.94 -0.39 3.06e-11 Platelet distribution width; CESC cis rs2204008 0.837 rs8189467 chr12:38241956 T/C cg26384229 chr12:38710491 ALG10B 0.64 8.89 0.48 9.98e-17 Bladder cancer; CESC cis rs11098499 0.779 rs10011097 chr4:120310359 T/G cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs9291683 0.620 rs11722946 chr4:10125990 A/G cg00071950 chr4:10020882 SLC2A9 -0.56 -8.45 -0.46 1.97e-15 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20376421 chr12:56546193 MYL6B 0.61 7.34 0.41 2.57e-12 Gut microbiome composition (summer); CESC cis rs782590 0.967 rs1084522 chr2:55843294 A/G cg18811423 chr2:55921094 PNPT1 0.81 13.24 0.63 4.56e-31 Metabolic syndrome; CESC cis rs959260 1.000 rs4788892 chr17:73391277 A/G cg20590849 chr17:73267439 MIF4GD -0.55 -6.35 -0.36 9.37e-10 Systemic lupus erythematosus; CESC cis rs11098499 0.754 rs2036857 chr4:120249240 T/C cg09307838 chr4:120376055 NA 0.77 10.35 0.54 2.54e-21 Corneal astigmatism; CESC cis rs9814567 1.000 rs7429866 chr3:134236306 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.15e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1670533 1.000 rs2290408 chr4:1067267 A/C cg04106633 chr4:1044584 NA -0.4 -5.25 -0.31 3.14e-7 Recombination rate (females); CESC cis rs3857536 0.813 rs62415859 chr6:66934278 G/A cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06934023 chr16:587828 SOLH 0.44 6.19 0.36 2.28e-9 Fibrinogen levels; CESC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg09323728 chr8:95962352 TP53INP1 -0.41 -8.97 -0.48 5.73e-17 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25790695 chr6:155635567 TFB1M 0.61 7.09 0.4 1.2e-11 Gut microbiome composition (summer); CESC cis rs6061231 0.740 rs11698650 chr20:60958374 A/T cg22633769 chr20:60982531 CABLES2 0.54 7.01 0.4 2e-11 Colorectal cancer; CESC cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg19729930 chr2:74357872 NA 0.86 12.98 0.62 3.73e-30 Gestational age at birth (maternal effect); CESC cis rs6121246 0.529 rs112367115 chr20:30178627 G/A cg13852791 chr20:30311386 BCL2L1 0.61 5.83 0.34 1.62e-8 Mean corpuscular hemoglobin; CESC trans rs4843747 0.671 rs8053377 chr16:88106465 A/G cg26811252 chr16:29126840 RRN3P2 0.67 9.25 0.49 7.99e-18 Menopause (age at onset); CESC cis rs6912958 0.559 rs242280 chr6:88048714 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.99 0.56 2.06e-23 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16298152 chr14:70234662 SFRS5;LOC100289511 -0.61 -6.57 -0.37 2.6200000000000003e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.73 -9.22 -0.49 9.33e-18 Alzheimer's disease; CESC cis rs3617 0.625 rs2240915 chr3:52859526 T/A cg07507251 chr3:52567010 NT5DC2 0.32 5.54 0.32 7.14e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs6893300 0.826 rs7734102 chr5:179153797 A/G cg14593053 chr5:179126677 CANX 0.47 5.18 0.3 4.4e-7 Resting heart rate; CESC cis rs2594989 0.945 rs2594969 chr3:11353399 C/G cg00170343 chr3:11313890 ATG7 0.54 5.48 0.32 9.97e-8 Circulating chemerin levels; CESC cis rs7116495 0.609 rs949324 chr11:71714526 G/C cg10381502 chr11:71823885 C11orf51 -1.13 -7.93 -0.44 6.3e-14 Severe influenza A (H1N1) infection; CESC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg01017244 chr2:74357527 NA 0.63 8.34 0.46 4.1e-15 Gestational age at birth (maternal effect); CESC cis rs9457247 0.967 rs1794694 chr6:167404751 T/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.42 -0.46 2.44e-15 Crohn's disease; CESC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg22800045 chr5:56110881 MAP3K1 0.81 9.66 0.51 4.1e-19 Initial pursuit acceleration; CESC cis rs847577 0.588 rs6946915 chr7:97711340 C/G cg24562669 chr7:97807699 LMTK2 0.78 13.35 0.63 1.91e-31 Breast cancer; CESC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.0 0.8 9.67e-62 Prudent dietary pattern; CESC cis rs453301 0.658 rs3855900 chr8:8901921 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -5.25 -0.31 3.08e-7 Joint mobility (Beighton score); CESC cis rs708547 0.581 rs6554400 chr4:57805306 A/C cg25525207 chr4:57843836 C4orf14;POLR2B 0.44 5.56 0.32 6.69e-8 Response to bleomycin (chromatid breaks); CESC cis rs2932538 0.961 rs2932534 chr1:113200797 A/G cg22162597 chr1:113214053 CAPZA1 0.57 7.33 0.41 2.88e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs7617773 0.539 rs2017859 chr3:48382261 G/A cg11946769 chr3:48343235 NME6 0.66 8.34 0.46 4.12e-15 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05609414 chr7:39873832 NA 0.39 6.26 0.36 1.58e-9 Fibrinogen levels; CESC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg07701084 chr6:150067640 NUP43 0.47 6.61 0.38 2.15e-10 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23227285 chr7:7676611 RPA3 -0.58 -6.7 -0.38 1.22e-10 Gut microbiome composition (summer); CESC cis rs9308731 0.591 rs7565473 chr2:111943790 G/A cg04202892 chr2:111875749 ACOXL 0.37 5.17 0.3 4.61e-7 Chronic lymphocytic leukemia; CESC cis rs7771547 0.573 rs547026 chr6:36398616 G/A cg04289385 chr6:36355825 ETV7 0.38 5.57 0.32 6.36e-8 Platelet distribution width; CESC cis rs67478160 0.643 rs3818085 chr14:104215985 C/T cg08213375 chr14:104286397 PPP1R13B 0.54 10.89 0.56 4.58e-23 Schizophrenia; CESC cis rs60843830 1.000 rs3791220 chr2:227066 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.38 0.54 2.05e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg01988459 chr11:68622903 NA -0.48 -6.39 -0.37 7.37e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7107174 1.000 rs10899489 chr11:78095373 G/T cg02023728 chr11:77925099 USP35 0.38 5.22 0.31 3.66e-7 Testicular germ cell tumor; CESC cis rs921968 0.529 rs6729341 chr2:219611434 T/G cg02176678 chr2:219576539 TTLL4 -0.47 -8.43 -0.46 2.28e-15 Mean corpuscular hemoglobin concentration; CESC cis rs7959452 0.535 rs1350166 chr12:69636314 G/T cg20891283 chr12:69753455 YEATS4 0.75 11.04 0.56 1.42e-23 Blood protein levels; CESC cis rs7980687 0.657 rs2851447 chr12:123665113 G/C cg05973401 chr12:123451056 ABCB9 0.46 5.75 0.33 2.41e-8 Height;Educational attainment;Head circumference (infant); CESC cis rs9488822 0.676 rs12524249 chr6:116368813 G/A cg26893134 chr6:116381904 FRK 0.25 6.08 0.35 4.07e-9 Cholesterol, total;LDL cholesterol; CESC cis rs2072499 0.750 rs7534339 chr1:156156219 A/G cg24450063 chr1:156163899 SLC25A44 0.99 12.16 0.6 2.49e-27 Testicular germ cell tumor; CESC cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg18876405 chr7:65276391 NA -0.6 -7.97 -0.44 4.77e-14 Aortic root size; CESC trans rs4332037 0.539 rs34809719 chr7:2028968 G/T cg11693508 chr17:37793320 STARD3 0.65 6.46 0.37 4.89e-10 Bipolar disorder; CESC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.14 -0.3 5.39e-7 Developmental language disorder (linguistic errors); CESC cis rs2732480 0.577 rs1489108 chr12:48738781 G/A cg04545296 chr12:48745243 ZNF641 0.44 7.29 0.41 3.69e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs1707322 1.000 rs3922887 chr1:46473802 A/G cg05343316 chr1:45956843 TESK2 0.44 5.35 0.31 1.9e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs709400 1.000 rs6593 chr14:104163282 G/A cg24130564 chr14:104152367 KLC1 -0.43 -5.41 -0.32 1.4e-7 Body mass index; CESC cis rs17209837 0.646 rs11532733 chr7:87117982 A/G cg00919237 chr7:87102261 ABCB4 -0.45 -5.66 -0.33 3.9e-8 Gallbladder cancer; CESC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg22920501 chr2:26401640 FAM59B -0.66 -7.89 -0.44 8.09e-14 Gut microbiome composition (summer); CESC cis rs7539542 0.536 rs12091234 chr1:202855508 C/T cg19681188 chr1:202830198 LOC148709 0.4 5.12 0.3 5.96e-7 Mean platelet volume; CESC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg22508957 chr16:3507546 NAT15 -0.68 -7.23 -0.41 5.11e-12 Tuberculosis; CESC cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg25517755 chr10:38738941 LOC399744 -0.47 -6.04 -0.35 5.12e-9 Extrinsic epigenetic age acceleration; CESC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.77 11.06 0.56 1.26e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.84 0.43 1.07e-13 Menopause (age at onset); CESC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 9.86 0.52 9.92e-20 Prudent dietary pattern; CESC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.23 0.41 5.1e-12 Height; CESC cis rs4629710 0.592 rs13206776 chr6:131576679 T/G cg12606694 chr6:131520996 AKAP7 0.48 5.84 0.34 1.51e-8 Multiple myeloma (IgH translocation); CESC cis rs965469 0.779 rs6037546 chr20:3298697 G/T cg25506879 chr20:3388711 C20orf194 -0.49 -5.39 -0.31 1.59e-7 IFN-related cytopenia; CESC cis rs72781680 1.000 rs72781665 chr2:24223086 G/A cg08917208 chr2:24149416 ATAD2B 0.94 8.36 0.46 3.58e-15 Lymphocyte counts; CESC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg26338869 chr17:61819248 STRADA 0.69 9.15 0.49 1.59e-17 Prudent dietary pattern; CESC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.37 -0.5 3.35e-18 Alzheimer's disease; CESC cis rs8044868 0.586 rs3844425 chr16:72194325 T/C cg16558253 chr16:72132732 DHX38 -0.4 -6.12 -0.35 3.31e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs9549367 0.789 rs9549365 chr13:113907391 C/T cg00898013 chr13:113819073 PROZ 0.52 7.42 0.41 1.59e-12 Platelet distribution width; CESC cis rs2797160 0.651 rs9491503 chr6:126031682 G/A cg05901451 chr6:126070800 HEY2 0.5 7.28 0.41 3.86e-12 Endometrial cancer; CESC cis rs6120849 0.518 rs11696652 chr20:33637060 T/G cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs2295359 0.892 rs12029362 chr1:67624231 G/A cg17031739 chr1:67600172 NA 0.4 5.24 0.31 3.23e-7 Psoriasis; CESC cis rs6815814 0.950 rs5743563 chr4:38806019 A/G cg02016764 chr4:38805732 TLR1 -0.63 -7.26 -0.41 4.22e-12 Breast cancer; CESC cis rs2404602 0.647 rs11072612 chr15:76960984 A/T cg23625390 chr15:77176239 SCAPER -0.41 -5.59 -0.32 5.64e-8 Blood metabolite levels; CESC cis rs9291683 0.530 rs998675 chr4:9948829 A/G cg11266682 chr4:10021025 SLC2A9 0.6 12.13 0.6 3.18e-27 Bone mineral density; CESC cis rs7188697 0.922 rs9924805 chr16:58615659 T/C cg02549819 chr16:58548995 SETD6 0.44 5.43 0.32 1.26e-7 QT interval; CESC cis rs920590 0.758 rs7012358 chr8:19662498 C/T cg01411142 chr8:19674711 INTS10 0.52 5.8 0.34 1.91e-8 Acute lymphoblastic leukemia (childhood); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26734912 chr5:128430241 ISOC1 -0.51 -6.53 -0.37 3.35e-10 Asthma; CESC cis rs2708240 1.000 rs7806512 chr7:147574555 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.37 -6.13 -0.35 3.19e-9 QT interval (drug interaction); CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg03188948 chr7:1209495 NA 0.7 7.76 0.43 1.82e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04486506 chr20:62577863 UCKL1 -0.54 -6.26 -0.36 1.52e-9 Gut microbiome composition (summer); CESC cis rs11608355 0.597 rs12579285 chr12:109832712 T/C cg19025524 chr12:109796872 NA -0.55 -7.83 -0.43 1.17e-13 Neuroticism; CESC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg23758822 chr17:41437982 NA 0.96 16.37 0.71 4.19e-42 Menopause (age at onset); CESC cis rs9457247 0.967 rs425039 chr6:167410527 C/T cg23791538 chr6:167370224 RNASET2 -0.61 -8.81 -0.48 1.71e-16 Crohn's disease; CESC cis rs425277 1.000 rs427811 chr1:2075560 T/G cg04315214 chr1:2043799 PRKCZ -0.39 -5.47 -0.32 1.04e-7 Height; CESC cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg22875332 chr1:76189707 ACADM 0.6 5.89 0.34 1.19e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 12.92 0.62 6.22e-30 Personality dimensions; CESC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg22920501 chr2:26401640 FAM59B 0.91 10.33 0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs3857067 1.000 rs1588381 chr4:95017558 C/T cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.05e-14 QT interval; CESC cis rs4595586 0.545 rs925829 chr12:39364167 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10657806 chr12:117348826 FBXW8 0.53 6.25 0.36 1.61e-9 Gut microbiome composition (summer); CESC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg19318889 chr4:1322082 MAEA -0.46 -6.0 -0.35 6.58e-9 Obesity-related traits; CESC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg17372223 chr3:52568218 NT5DC2 0.43 6.51 0.37 3.76e-10 Bipolar disorder; CESC cis rs1707322 0.685 rs56177313 chr1:46225806 A/C cg06784218 chr1:46089804 CCDC17 0.41 7.22 0.41 5.64e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7772486 0.712 rs6570726 chr6:146159460 T/C cg23711669 chr6:146136114 FBXO30 0.7 10.39 0.54 1.98e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs6775745 0.654 rs9289414 chr3:131785226 C/T cg12213930 chr3:131751605 CPNE4 0.46 5.19 0.3 4.09e-7 Neutrophil count; CESC cis rs2549003 1.000 rs2070723 chr5:131823187 A/G cg02551604 chr5:131831745 NA -0.38 -5.39 -0.31 1.6e-7 Asthma (sex interaction); CESC cis rs6088590 0.931 rs6088617 chr20:33408036 G/A cg08999081 chr20:33150536 PIGU 0.59 8.94 0.48 6.65e-17 Coronary artery disease; CESC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg04876069 chr12:132293656 NA -0.41 -5.65 -0.33 4.12e-8 Migraine; CESC cis rs4660306 0.677 rs781059 chr1:45934562 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -5.27 -0.31 2.84e-7 Homocysteine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22794378 chr14:89029563 ZC3H14 0.54 6.02 0.35 5.88e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs9497427 chr6:146238302 T/A cg05347473 chr6:146136440 FBXO30 -0.53 -6.92 -0.39 3.46e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs116095464 0.558 rs6882584 chr5:223411 A/C cg00938859 chr5:1591904 SDHAP3 0.6 6.66 0.38 1.55e-10 Breast cancer; CESC cis rs634534 0.622 rs531612 chr11:65705432 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.55 -6.75 -0.38 9.5e-11 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs10788264 0.504 rs7090214 chr10:124036494 T/C cg09507567 chr10:124027408 NA 0.38 5.29 0.31 2.52e-7 Total body bone mineral density; CESC cis rs2635047 1.000 rs2635045 chr18:44668417 T/C cg19077165 chr18:44547161 KATNAL2 -0.42 -5.67 -0.33 3.8e-8 Educational attainment; CESC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1538970 0.961 rs7543428 chr1:45839643 A/G cg06784218 chr1:46089804 CCDC17 0.36 6.12 0.35 3.44e-9 Platelet count; CESC cis rs2249625 0.523 rs2463702 chr6:72853778 A/G cg18830697 chr6:72922368 RIMS1 0.41 6.2 0.36 2.15e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg17372223 chr3:52568218 NT5DC2 0.41 6.27 0.36 1.43e-9 Electroencephalogram traits; CESC cis rs9399135 0.933 rs7755680 chr6:135294259 A/G cg22676075 chr6:135203613 NA 0.52 7.21 0.4 5.94e-12 Red blood cell count; CESC cis rs4132509 0.947 rs10927041 chr1:243731890 T/C cg21452805 chr1:244014465 NA 0.45 5.37 0.31 1.7e-7 RR interval (heart rate); CESC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg24881330 chr22:46731750 TRMU 0.77 6.19 0.36 2.26e-9 LDL cholesterol;Cholesterol, total; CESC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg20735989 chr4:730612 PCGF3 -0.59 -7.13 -0.4 9.63e-12 White blood cell count; CESC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg22920501 chr2:26401640 FAM59B -0.44 -5.38 -0.31 1.61e-7 Gut microbiome composition (summer); CESC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg06481639 chr22:41940642 POLR3H -0.55 -6.01 -0.35 6.05e-9 Vitiligo; CESC cis rs11098499 0.909 rs17046118 chr4:120387496 T/G cg09307838 chr4:120376055 NA 0.95 13.96 0.65 1.42e-33 Corneal astigmatism; CESC cis rs2439831 0.850 rs2439832 chr15:43779686 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.82 11.58 0.58 2.38e-25 Lung cancer in ever smokers; CESC cis rs9623117 0.915 rs11704416 chr22:40436973 G/C cg05033341 chr22:40419857 FAM83F -0.49 -5.4 -0.31 1.5e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs4268898 0.662 rs56006260 chr2:24409903 A/G cg08917208 chr2:24149416 ATAD2B 0.58 5.39 0.31 1.58e-7 Asthma; CESC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.11 0.4 1.05e-11 Bipolar disorder; CESC cis rs2282802 0.685 rs7737543 chr5:139646026 A/G cg26211634 chr5:139558579 C5orf32 0.51 7.45 0.42 1.3e-12 Intelligence (multi-trait analysis); CESC cis rs17253792 0.822 rs17685053 chr14:56125771 T/A cg01858014 chr14:56050164 KTN1 -0.71 -6.21 -0.36 2.02e-9 Putamen volume; CESC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg19766460 chr21:43528205 UMODL1;C21orf128 0.98 13.93 0.65 1.84e-33 IgG glycosylation; CESC cis rs5769765 0.908 rs138864 chr22:50204712 G/A cg02269571 chr22:50332266 NA -0.42 -5.35 -0.31 1.92e-7 Schizophrenia; CESC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg12963246 chr6:28129442 ZNF389 0.57 7.78 0.43 1.65e-13 Depression; CESC cis rs6460942 0.556 rs2287067 chr7:12370533 T/C cg06484146 chr7:12443880 VWDE -0.51 -7.22 -0.41 5.49e-12 Coronary artery disease; CESC cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg02773041 chr1:40204384 PPIE 0.53 7.37 0.41 2.13e-12 Blood protein levels; CESC trans rs11039798 1.000 rs7928243 chr11:48589192 A/T cg15704280 chr7:45808275 SEPT13 0.7 6.57 0.37 2.68e-10 Axial length; CESC cis rs7017914 0.935 rs56289931 chr8:71837754 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.43 -5.46 -0.32 1.09e-7 Bone mineral density; CESC cis rs2832191 0.720 rs2832200 chr21:30499165 G/A cg24692254 chr21:30365293 RNF160 -0.79 -12.11 -0.6 3.71e-27 Dental caries; CESC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg04553112 chr3:125709451 NA -0.49 -5.27 -0.31 2.77e-7 Blood pressure (smoking interaction); CESC cis rs6840360 0.967 rs7695162 chr4:152510541 G/A cg22705602 chr4:152727874 NA -0.35 -5.2 -0.3 4.01e-7 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24701985 chr7:149535383 ZNF862 0.5 6.48 0.37 4.52e-10 Gut microbiota (bacterial taxa); CESC cis rs55692468 0.606 rs1878632 chr2:153323158 A/C cg04681845 chr2:153283485 FMNL2 -0.28 -5.73 -0.33 2.76e-8 Intraocular pressure; CESC cis rs7662987 0.793 rs28730632 chr4:99995703 G/A cg13256891 chr4:100009986 ADH5 -0.59 -5.12 -0.3 5.89e-7 Smoking initiation; CESC cis rs7772486 0.686 rs10872579 chr6:145966012 C/G cg23711669 chr6:146136114 FBXO30 0.8 11.21 0.57 4.03e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs11190604 1.000 rs9420785 chr10:102240451 C/G cg07080220 chr10:102295463 HIF1AN 0.56 5.54 0.32 7.32e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7914558 0.966 rs12569617 chr10:104729996 T/C cg15744005 chr10:104629667 AS3MT -0.34 -5.31 -0.31 2.32e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg09417038 chr21:47716443 C21orf57 0.44 6.22 0.36 1.94e-9 Testicular germ cell tumor; CESC cis rs977987 0.800 rs11645329 chr16:75336679 C/G cg03315344 chr16:75512273 CHST6 0.39 5.48 0.32 1.01e-7 Dupuytren's disease; CESC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg25072359 chr17:41440525 NA 0.47 6.18 0.36 2.36e-9 Menopause (age at onset); CESC cis rs11030122 0.702 rs12281293 chr11:3963814 C/T cg18678763 chr11:4115507 RRM1 -0.5 -6.64 -0.38 1.78e-10 Mean platelet volume;Platelet distribution width; CESC trans rs7246657 0.943 rs8106839 chr19:37958475 C/G cg01833234 chr11:6592585 DNHD1 0.53 6.03 0.35 5.61e-9 Coronary artery calcification; CESC cis rs4969178 0.622 rs4129767 chr17:76403984 G/A cg05887092 chr17:76393375 PGS1 0.7 11.6 0.58 1.94e-25 HDL cholesterol levels; CESC cis rs8067545 0.717 rs34401389 chr17:19989436 A/T cg13482628 chr17:19912719 NA 0.39 5.34 0.31 1.97e-7 Schizophrenia; CESC cis rs6120849 0.901 rs6060266 chr20:33733078 T/C cg24642439 chr20:33292090 TP53INP2 0.62 6.56 0.37 2.84e-10 Protein C levels; CESC cis rs7178572 0.568 rs7167794 chr15:77635875 T/C cg22256960 chr15:77711686 NA -0.54 -6.86 -0.39 4.9e-11 Type 2 diabetes; CESC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg23281280 chr6:28129359 ZNF389 0.5 6.98 0.39 2.39e-11 Depression; CESC cis rs16867321 0.951 rs13413574 chr2:181364491 A/G cg23363182 chr2:181467187 NA -0.41 -5.13 -0.3 5.65e-7 Obesity; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg08448040 chr3:13521693 HDAC11 -0.56 -6.29 -0.36 1.28e-9 Subjective well-being; CESC cis rs7208859 0.573 rs8078182 chr17:29149664 C/T cg19761014 chr17:28927070 LRRC37B2 0.63 6.26 0.36 1.52e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14309501 chr19:17445715 ANO8 0.58 6.68 0.38 1.44e-10 Gut microbiome composition (summer); CESC cis rs826838 0.967 rs6580726 chr12:39108623 T/C cg13010199 chr12:38710504 ALG10B -0.42 -5.9 -0.34 1.13e-8 Heart rate; CESC cis rs6831352 0.760 rs2602859 chr4:100030583 G/A cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Alcohol dependence; CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg07157834 chr1:205819609 PM20D1 -0.55 -8.38 -0.46 3.13e-15 Monocyte percentage of white cells; CESC cis rs4253772 0.591 rs11703848 chr22:46685131 A/G cg10541313 chr22:46663664 TTC38 0.72 5.15 0.3 5.01e-7 LDL cholesterol;Cholesterol, total; CESC cis rs13191362 0.507 rs2849525 chr6:163126652 A/C cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -6.67 -0.38 1.47e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7560272 0.538 rs12053242 chr2:73937168 G/A cg20560298 chr2:73613845 ALMS1 0.42 5.8 0.34 1.87e-8 Schizophrenia; CESC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg09263875 chr16:632152 PIGQ 0.67 11.4 0.57 9.36e-25 Height; CESC cis rs9486715 0.867 rs2475025 chr6:96988696 A/T cg18709589 chr6:96969512 KIAA0776 -0.46 -6.43 -0.37 5.85e-10 Headache; CESC cis rs977987 0.806 rs11862095 chr16:75385418 T/A cg03315344 chr16:75512273 CHST6 0.42 6.12 0.35 3.44e-9 Dupuytren's disease; CESC cis rs317689 0.680 rs315140 chr12:69790780 A/T cg20891283 chr12:69753455 YEATS4 0.61 7.06 0.4 1.47e-11 Response to diuretic therapy; CESC cis rs6500395 0.963 rs4785248 chr16:48687947 A/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs854765 0.547 rs4643387 chr17:17972973 C/T cg04398451 chr17:18023971 MYO15A -0.69 -9.75 -0.51 2.14e-19 Total body bone mineral density; CESC cis rs1865760 0.566 rs4529296 chr6:26083135 C/G cg17691542 chr6:26056736 HIST1H1C 0.42 5.57 0.32 6.13e-8 Height; CESC cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg27478167 chr7:817139 HEATR2 -0.47 -5.61 -0.33 5.18e-8 Cerebrospinal P-tau181p levels; CESC cis rs6540559 0.543 rs650728 chr1:210433351 C/T cg25204440 chr1:209979598 IRF6 0.49 5.14 0.3 5.28e-7 Cleft lip with or without cleft palate; CESC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.56 -0.32 6.47e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs870825 0.616 rs7683799 chr4:185632164 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.91 0.39 3.51e-11 Blood protein levels; CESC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg21280719 chr6:42927975 GNMT -0.32 -7.33 -0.41 2.81e-12 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg11366901 chr6:160182831 ACAT2 0.8 10.07 0.53 2.14e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs1348850 0.632 rs4470372 chr2:178505857 G/A cg23306229 chr2:178417860 TTC30B 0.59 7.38 0.41 2.07e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11143796 chr4:178363279 AGA -0.48 -6.23 -0.36 1.8e-9 Ulcerative colitis; CESC cis rs17376456 0.569 rs6881815 chr5:93105666 A/G cg21475434 chr5:93447410 FAM172A 0.49 5.04 0.3 8.6e-7 Diabetic retinopathy; CESC cis rs6499255 0.903 rs1800566 chr16:69745145 C/T cg15192750 chr16:69999425 NA 0.53 6.21 0.36 2.03e-9 IgE levels; CESC cis rs7772486 0.790 rs2253768 chr6:146199922 A/G cg05347473 chr6:146136440 FBXO30 0.58 7.36 0.41 2.25e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg11764359 chr7:65958608 NA -0.78 -11.56 -0.58 2.78e-25 Aortic root size; CESC cis rs34779708 0.766 rs35308730 chr10:35549796 C/T cg03585969 chr10:35415529 CREM 0.54 6.14 0.35 2.97e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg24250549 chr1:154909240 PMVK 0.75 11.18 0.57 5.12e-24 Prostate cancer; CESC cis rs9549260 0.617 rs9549266 chr13:41278409 C/G cg21288729 chr13:41239152 FOXO1 0.58 5.06 0.3 8e-7 Red blood cell count; CESC cis rs12477438 0.539 rs12999417 chr2:99865548 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.78 -12.75 -0.62 2.32e-29 Chronic sinus infection; CESC trans rs2018683 0.707 rs2057957 chr7:28974626 A/C cg19402173 chr7:128379420 CALU 0.51 6.66 0.38 1.55e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.81 0.34 1.79e-8 Electroencephalogram traits; CESC cis rs11048434 0.736 rs1805724 chr12:9104609 T/C cg04155231 chr12:9217510 LOC144571 0.32 5.06 0.3 7.88e-7 Sjögren's syndrome; CESC cis rs2797160 1.000 rs1739362 chr6:126020703 A/T cg05901451 chr6:126070800 HEY2 0.45 6.5 0.37 3.9e-10 Endometrial cancer; CESC trans rs916888 0.610 rs199529 chr17:44837217 A/C cg01341218 chr17:43662625 NA 0.68 8.74 0.47 2.68e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg02038168 chr22:39784481 NA -0.64 -8.25 -0.45 7.52e-15 Intelligence (multi-trait analysis); CESC cis rs7116495 1.000 rs675185 chr11:71775572 T/G cg26138937 chr11:71823887 C11orf51 -0.83 -6.95 -0.39 2.81e-11 Severe influenza A (H1N1) infection; CESC cis rs4728302 0.838 rs10225115 chr7:133591435 C/T cg10665199 chr7:133106180 EXOC4 0.38 5.32 0.31 2.16e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs11758351 0.660 rs16891443 chr6:26221937 A/C cg23601095 chr6:26197514 HIST1H3D 0.91 9.96 0.52 4.64e-20 Gout;Renal underexcretion gout; CESC trans rs4824093 0.545 rs58876234 chr22:50258868 G/A cg09872104 chr7:134855509 C7orf49 -0.97 -6.92 -0.39 3.45e-11 Amyotrophic lateral sclerosis (sporadic); CESC cis rs12586317 0.508 rs8015350 chr14:35635230 A/T cg16230307 chr14:35515116 FAM177A1 0.4 5.04 0.3 8.74e-7 Psoriasis; CESC cis rs35110281 0.641 rs9978858 chr21:45085552 A/G cg04455712 chr21:45112962 RRP1B 0.49 7.11 0.4 1.06e-11 Mean corpuscular volume; CESC cis rs12136530 0.774 rs10442634 chr1:19775246 C/T cg01832549 chr1:19774989 CAPZB -0.47 -6.84 -0.39 5.52e-11 Lead levels in blood; CESC cis rs56104184 0.775 rs73061699 chr19:49400511 T/C cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg02951883 chr7:2050386 MAD1L1 -0.55 -7.16 -0.4 8.05e-12 Bipolar disorder and schizophrenia; CESC cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg01475377 chr6:109611718 NA -0.51 -8.56 -0.47 9.09e-16 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22137448 chr16:2318988 RNPS1 0.57 6.65 0.38 1.68e-10 Gut microbiome composition (summer); CESC cis rs2835872 0.733 rs1787393 chr21:39035934 G/A cg06728970 chr21:39037746 KCNJ6 0.3 5.57 0.32 6.13e-8 Electroencephalographic traits in alcoholism; CESC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 1.02 16.49 0.71 1.54e-42 Subjective well-being; CESC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg13206674 chr6:150067644 NUP43 0.41 5.68 0.33 3.52e-8 Lung cancer; CESC cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg02551604 chr5:131831745 NA -0.37 -5.22 -0.31 3.53e-7 Asthma (sex interaction); CESC cis rs10791097 0.694 rs7106684 chr11:130758153 A/T cg12179176 chr11:130786555 SNX19 0.65 10.09 0.53 1.76e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs225245 0.817 rs225302 chr17:33922396 C/T cg05299278 chr17:33885742 SLFN14 0.38 5.39 0.31 1.57e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs644799 1.000 rs474252 chr11:95619292 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.84 12.04 0.59 6.53e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9929218 1.000 rs67359183 chr16:68814204 T/C cg02972257 chr16:68554789 NA 0.48 5.71 0.33 2.96e-8 Colorectal cancer; CESC cis rs7208859 0.673 rs216410 chr17:28903831 C/G cg19761014 chr17:28927070 LRRC37B2 -0.7 -7.07 -0.4 1.35e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25781121 chr3:48282641 ZNF589 -0.52 -6.55 -0.37 3.03e-10 Fibrinogen levels; CESC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.77 11.06 0.56 1.26e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs4594175 0.926 rs10138269 chr14:51615360 T/C cg23942311 chr14:51606299 NA 0.39 5.95 0.34 8.64e-9 Cancer; CESC cis rs79387448 0.655 rs77763678 chr2:102916749 G/A cg09003973 chr2:102972529 NA 1.06 7.88 0.44 8.27e-14 Gut microbiota (bacterial taxa); CESC cis rs656900 0.647 rs600671 chr15:80117232 A/G cg02196730 chr15:80188777 MTHFS 0.4 5.21 0.3 3.75e-7 Cerebrospinal P-tau181p levels; CESC cis rs9399137 0.507 rs35571217 chr6:135290355 T/C cg22676075 chr6:135203613 NA 0.53 7.0 0.39 2.14e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs6963495 0.649 rs1706888 chr7:105149176 A/G cg19920283 chr7:105172520 RINT1 0.53 6.19 0.36 2.3e-9 Bipolar disorder (body mass index interaction); CESC cis rs17253792 0.732 rs79014965 chr14:56117551 T/G cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.65 0.33 4.2e-8 Putamen volume; CESC cis rs6502050 0.835 rs4789665 chr17:80168097 A/C cg23985595 chr17:80112537 CCDC57 -0.4 -6.27 -0.36 1.45e-9 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03330302 chr2:26468406 HADHA;HADHB -0.55 -6.56 -0.37 2.88e-10 Gut microbiome composition (summer); CESC trans rs3780486 0.881 rs10738906 chr9:33135634 T/C cg04842962 chr6:43655489 MRPS18A 1.0 19.15 0.76 6.75e-52 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03603505 chr12:122839920 CLIP1 -0.52 -6.04 -0.35 5.22e-9 Gut microbiome composition (summer); CESC cis rs863345 0.604 rs879635 chr1:158462908 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.53e-11 Pneumococcal bacteremia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00524296 chr16:88928681 PABPN1L 0.43 6.52 0.37 3.47e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17253792 0.822 rs77555779 chr14:56078430 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.43 5.76 0.33 2.28e-8 Bipolar disorder; CESC cis rs4589502 0.841 rs55855162 chr15:67140523 C/A cg12317470 chr15:67143691 NA 0.75 6.84 0.39 5.53e-11 Lung cancer (smoking interaction); CESC cis rs11785400 0.928 rs2280878 chr8:143722366 G/A cg24634471 chr8:143751801 JRK 0.45 5.83 0.34 1.6e-8 Schizophrenia; CESC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.33 -5.06 -0.3 7.93e-7 Longevity;Endometriosis; CESC cis rs873946 0.504 rs12775990 chr10:134575836 C/T cg27286337 chr10:134555280 INPP5A 0.71 8.26 0.45 6.86e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9911578 1.000 rs9901114 chr17:56575208 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -5.35 -0.31 1.88e-7 Intelligence (multi-trait analysis); CESC cis rs965469 0.779 rs6051740 chr20:3301165 T/C cg25506879 chr20:3388711 C20orf194 -0.49 -5.41 -0.32 1.44e-7 IFN-related cytopenia; CESC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg00431813 chr7:1051703 C7orf50 -0.35 -5.46 -0.32 1.09e-7 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02372056 chr11:64684731 ATG2A -0.61 -6.63 -0.38 1.88e-10 Gut microbiome composition (summer); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg06714086 chr11:33182787 CSTF3 -0.47 -6.17 -0.35 2.6e-9 Height; CESC trans rs6035275 1.000 rs7267420 chr20:19320392 A/G cg17643624 chr13:111281037 CARKD 0.75 6.0 0.35 6.52e-9 QT interval (sulfonylurea treatment interaction); CESC cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg22875332 chr1:76189707 ACADM 0.48 5.56 0.32 6.54e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg18357526 chr6:26021779 HIST1H4A 0.6 8.28 0.45 6.17e-15 Intelligence (multi-trait analysis); CESC cis rs6460942 0.597 rs4721108 chr7:12535247 C/T cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs17666538 0.591 rs2878547 chr8:603416 G/A cg26554054 chr8:600488 NA 0.6 5.14 0.3 5.37e-7 IgG glycosylation; CESC cis rs9649213 0.614 rs3944111 chr7:98005766 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.44 -6.06 -0.35 4.75e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2243480 0.901 rs35087093 chr7:65405208 C/T cg12463550 chr7:65579703 CRCP 0.7 5.58 0.32 5.87e-8 Diabetic kidney disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03560797 chr7:106301641 FLJ36031 0.48 6.42 0.37 6.13e-10 Gut microbiota (bacterial taxa); CESC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg00409905 chr10:38381863 ZNF37A -0.47 -6.33 -0.36 1.04e-9 Extrinsic epigenetic age acceleration; CESC trans rs9951602 0.512 rs9946115 chr18:76654531 A/C cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs7208859 0.673 rs216409 chr17:28906269 C/T cg17105886 chr17:28927953 LRRC37B2 -0.58 -5.22 -0.31 3.55e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs1977584 0.573 rs1325161 chr10:45396569 G/T cg09262100 chr14:103416268 CDC42BPB 0.61 6.14 0.35 3.02e-9 Selective IgA deficiency; CESC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg02569458 chr12:86230093 RASSF9 -0.42 -6.43 -0.37 5.94e-10 Major depressive disorder; CESC cis rs9300255 0.602 rs1716164 chr12:123663660 G/A cg19016782 chr12:123741754 C12orf65 -0.45 -6.4 -0.37 6.92e-10 Neutrophil percentage of white cells; CESC cis rs644799 0.710 rs12273579 chr11:95524421 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.76 11.03 0.56 1.55e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3740713 1.000 rs12289603 chr11:18471370 T/C cg23797887 chr11:18477753 LDHAL6A -0.56 -5.93 -0.34 9.58e-9 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg00129232 chr17:37814104 STARD3 0.54 7.03 0.4 1.75e-11 Glomerular filtration rate (creatinine); CESC cis rs9512730 0.553 rs9507904 chr13:28049506 C/T cg08193333 chr13:27998609 GTF3A 0.44 5.3 0.31 2.42e-7 Schizophrenia; CESC cis rs7680126 0.632 rs78030862 chr4:10150412 G/A cg11266682 chr4:10021025 SLC2A9 -0.52 -6.51 -0.37 3.81e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25346720 chr7:73184981 CLDN3 -0.46 -6.97 -0.39 2.48e-11 Gambling; CESC cis rs2276314 0.857 rs28435069 chr18:33628475 A/G cg19628046 chr18:33552617 C18orf21 0.53 5.97 0.34 7.5e-9 Endometriosis;Drug-induced torsades de pointes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22967283 chr7:4815538 KIAA0415 0.6 6.75 0.38 9.11e-11 Gut microbiome composition (summer); CESC cis rs524281 0.861 rs10750779 chr11:65974591 C/G cg14036092 chr11:66035641 RAB1B -0.59 -6.05 -0.35 4.86e-9 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02182185 chr11:47600575 NDUFS3;KBTBD4 0.61 7.1 0.4 1.15e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13964393 chr15:45003702 B2M -0.57 -6.85 -0.39 5.07e-11 Gut microbiome composition (summer); CESC cis rs9303280 0.806 rs36095411 chr17:38031865 T/G cg20243544 chr17:37824526 PNMT 0.53 6.97 0.39 2.46e-11 Self-reported allergy; CESC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.13e-10 Bipolar disorder; CESC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.56 0.37 2.8e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg04234412 chr22:24373322 LOC391322 0.73 11.44 0.57 6.79e-25 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7818688 0.556 rs2678823 chr8:96046094 G/A cg16049864 chr8:95962084 TP53INP1 -0.46 -5.27 -0.31 2.77e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs896854 0.517 rs896851 chr8:95950251 T/C cg16049864 chr8:95962084 TP53INP1 -0.52 -7.28 -0.41 3.87e-12 Type 2 diabetes; CESC cis rs4930103 0.619 rs10769945 chr11:1985127 C/T cg23202291 chr11:1979235 NA 0.38 5.4 0.31 1.47e-7 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs563538 1 rs563538 chr13:37433721 A/G cg08717751 chr13:37881008 NA -0.68 -5.47 -0.32 1.06e-7 Spontaneous preterm birth (preterm birth); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12939298 chr14:75643618 TMED10 -0.62 -6.88 -0.39 4.31e-11 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15320925 chr11:207681 BET1L;RIC8A -0.46 -6.01 -0.35 5.97e-9 Gut microbiota (bacterial taxa); CESC cis rs763014 0.833 rs3743904 chr16:632767 A/G cg07343612 chr16:622815 PIGQ -0.58 -8.42 -0.46 2.38e-15 Height; CESC cis rs6582630 0.502 rs12815350 chr12:38439921 A/T cg13010199 chr12:38710504 ALG10B 0.46 5.9 0.34 1.1e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg00033643 chr7:134001901 SLC35B4 0.41 5.26 0.31 2.93e-7 Mean platelet volume; CESC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg09359103 chr1:154839909 KCNN3 0.66 12.35 0.6 5.55e-28 Prostate cancer; CESC cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg03433033 chr1:76189801 ACADM 0.62 7.21 0.4 5.97e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs62005083 1.000 rs72725960 chr14:74582154 A/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.7 5.25 0.31 3.08e-7 Mean corpuscular volume; CESC cis rs7843479 0.601 rs4872204 chr8:21841396 T/C cg17168535 chr8:21777572 XPO7 0.72 11.6 0.58 1.99e-25 Mean corpuscular volume; CESC cis rs12477438 1.000 rs12466388 chr2:99916538 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.15 -0.4 8.59e-12 Chronic sinus infection; CESC cis rs79839061 0.610 rs34006051 chr4:847445 C/T cg07828340 chr4:882639 GAK 1.07 8.16 0.45 1.38e-14 Intelligence (multi-trait analysis); CESC cis rs5758511 0.680 rs5758651 chr22:42609148 T/C cg00645731 chr22:42541494 CYP2D7P1 0.59 8.71 0.47 3.36e-16 Birth weight; CESC cis rs10465746 0.780 rs11163865 chr1:84366917 C/T cg10977910 chr1:84465055 TTLL7 0.52 7.06 0.4 1.46e-11 Obesity-related traits; CESC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg00101154 chr16:420108 MRPL28 -0.54 -7.13 -0.4 9.75e-12 Bone mineral density (spine);Bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23358871 chr17:78121069 EIF4A3 0.46 6.27 0.36 1.5e-9 Gut microbiota (bacterial taxa); CESC cis rs4664304 0.658 rs2667008 chr2:160865095 C/T cg03641300 chr2:160917029 PLA2R1 -0.48 -6.84 -0.39 5.58e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.81 -11.35 -0.57 1.34e-24 Prudent dietary pattern; CESC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg20243544 chr17:37824526 PNMT -0.45 -5.48 -0.32 9.91e-8 Glomerular filtration rate (creatinine); CESC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 11.52 0.58 3.61e-25 Alzheimer's disease; CESC cis rs3733585 0.673 rs4495037 chr4:9954050 C/G cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg11764359 chr7:65958608 NA -0.78 -11.61 -0.58 1.78e-25 Aortic root size; CESC cis rs1595825 0.891 rs6707521 chr2:198713231 A/G cg00982548 chr2:198649783 BOLL 0.48 5.09 0.3 6.92e-7 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22094802 chr19:45946652 NA -0.48 -6.3 -0.36 1.26e-9 Fibrinogen levels; CESC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.81 8.21 0.45 9.45e-15 Platelet count; CESC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 11.11 0.56 8.67e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8072100 0.840 rs9912311 chr17:45547132 T/C cg08085267 chr17:45401833 C17orf57 -0.55 -7.47 -0.42 1.13e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs4561483 0.831 rs33621 chr16:12008513 G/A cg08843971 chr16:11963173 GSPT1 -0.42 -5.75 -0.33 2.48e-8 Testicular germ cell tumor; CESC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.32 -0.31 2.21e-7 Total body bone mineral density; CESC cis rs2559856 1.000 rs2559857 chr12:102089399 A/C cg12213457 chr12:102090980 CHPT1 -0.37 -5.48 -0.32 9.79e-8 Blood protein levels; CESC cis rs2243480 1.000 rs781156 chr7:65479141 C/A cg12463550 chr7:65579703 CRCP 0.72 5.81 0.34 1.8e-8 Diabetic kidney disease; CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg18337363 chr3:52569053 NT5DC2 0.35 6.91 0.39 3.54e-11 Electroencephalogram traits; CESC cis rs798554 0.600 rs2679259 chr7:2885322 C/G cg19717773 chr7:2847554 GNA12 -0.49 -7.43 -0.42 1.5e-12 Height; CESC cis rs56104184 0.775 rs55981795 chr19:49401952 A/C cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg09060608 chr5:178986726 RUFY1 0.5 7.38 0.41 1.99e-12 Lung cancer; CESC cis rs561341 0.623 rs4795665 chr17:30233657 C/T cg13647721 chr17:30228624 UTP6 0.8 9.63 0.51 5.09e-19 Hip circumference adjusted for BMI; CESC cis rs3015497 0.603 rs2934686 chr14:51029713 A/G cg26011998 chr14:51135199 SAV1 0.47 5.36 0.31 1.8e-7 Mean platelet volume; CESC cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg01579765 chr21:45077557 HSF2BP -0.52 -8.54 -0.46 1.05e-15 Mean corpuscular volume; CESC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg05564831 chr3:52568323 NT5DC2 0.42 6.14 0.35 3.08e-9 Bipolar disorder; CESC cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.850 rs17233455 chr16:89816407 A/G cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs28655083 0.843 rs1502433 chr16:77087101 C/T cg01753188 chr16:77233325 SYCE1L;MON1B 0.42 5.5 0.32 8.89e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs6456156 0.586 rs2017338 chr6:167471714 G/A cg23791538 chr6:167370224 RNASET2 -0.5 -6.44 -0.37 5.46e-10 Primary biliary cholangitis; CESC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg23758822 chr17:41437982 NA 1.02 15.29 0.68 2.9e-38 Menopause (age at onset); CESC cis rs7208859 0.562 rs11650923 chr17:29008167 G/A cg13385521 chr17:29058706 SUZ12P 0.72 5.62 0.33 4.72e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg26597838 chr10:835615 NA 0.9 9.35 0.5 3.76e-18 Eosinophil percentage of granulocytes; CESC cis rs6952809 0.532 rs6461361 chr7:2432167 A/G cg05083358 chr7:2394359 EIF3B -0.6 -5.08 -0.3 7.24e-7 Multiple sclerosis; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg12609600 chr11:1595974 HCCA2;LOC338651 0.38 6.32 0.36 1.11e-9 Vertical cup-disc ratio; CESC cis rs7666738 0.830 rs28417716 chr4:98864859 C/T cg05340658 chr4:99064831 C4orf37 0.75 11.16 0.57 5.89e-24 Colonoscopy-negative controls vs population controls; CESC cis rs7605827 0.930 rs11681044 chr2:15717058 G/A cg19274914 chr2:15703543 NA 0.31 5.58 0.32 6.03e-8 Educational attainment (years of education); CESC cis rs950169 0.887 rs71395453 chr15:85113490 G/C cg17507749 chr15:85114479 UBE2QP1 0.54 6.11 0.35 3.61e-9 Schizophrenia; CESC cis rs7617773 0.563 rs13082269 chr3:48392274 G/A cg11946769 chr3:48343235 NME6 0.64 8.04 0.44 2.93e-14 Coronary artery disease; CESC cis rs11690935 0.632 rs1607254 chr2:172626552 A/G cg13550731 chr2:172543902 DYNC1I2 0.6 8.29 0.45 5.76e-15 Schizophrenia; CESC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg07414643 chr4:187882934 NA 0.48 6.92 0.39 3.35e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg01516881 chr6:292596 DUSP22 -0.53 -6.83 -0.39 5.71e-11 Menopause (age at onset); CESC cis rs7412746 0.611 rs2256355 chr1:150811794 A/G cg04414720 chr1:150670196 GOLPH3L 0.46 6.26 0.36 1.57e-9 Melanoma; CESC trans rs2455012 1.000 rs9436757 chr1:66528892 C/T cg23678594 chr1:1712021 NA 0.83 6.24 0.36 1.72e-9 Staphylococcus aureus infection; CESC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.71 6.25 0.36 1.59e-9 Platelet count; CESC cis rs1348850 0.526 rs10497504 chr2:178370040 T/C cg23306229 chr2:178417860 TTC30B 0.78 6.92 0.39 3.32e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg04166393 chr7:2884313 GNA12 0.37 5.07 0.3 7.44e-7 Height; CESC cis rs17376456 0.825 rs6865441 chr5:93284746 G/A cg25358565 chr5:93447407 FAM172A 1.14 9.72 0.51 2.6e-19 Diabetic retinopathy; CESC cis rs904251 0.737 rs914347 chr6:37484970 A/C cg01843034 chr6:37503916 NA -0.28 -5.03 -0.3 9.16e-7 Cognitive performance; CESC cis rs78456975 1.000 rs10192959 chr2:1553393 G/T cg01028140 chr2:1542097 TPO -0.59 -5.77 -0.33 2.23e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs34779708 0.931 rs7908573 chr10:35309513 T/C cg03585969 chr10:35415529 CREM 0.74 9.69 0.51 3.4e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs10911251 0.546 rs2027081 chr1:183074576 A/G ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.09e-34 Colorectal cancer; CESC cis rs4568518 0.530 rs12699921 chr7:17994494 G/A cg03009463 chr7:17980271 SNX13 0.41 5.39 0.31 1.56e-7 Measles; CESC cis rs1348850 0.519 rs1527406 chr2:178525655 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.05 0.4 1.57e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs939574 0.512 rs10194278 chr2:220138408 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.45 5.37 0.31 1.75e-7 Platelet distribution width; CESC cis rs4523957 0.890 rs12941836 chr17:2194874 C/G cg16513277 chr17:2031491 SMG6 0.6 8.18 0.45 1.15e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs12900413 0.687 rs12908343 chr15:90319095 C/T cg24249390 chr15:90295951 MESP1 -0.42 -5.81 -0.34 1.78e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs6563842 0.528 rs56340348 chr13:41296371 C/T cg21288729 chr13:41239152 FOXO1 0.58 7.47 0.42 1.13e-12 Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CESC cis rs2243480 0.901 rs73148097 chr7:65431787 A/C cg25894440 chr7:65020034 NA -0.68 -5.88 -0.34 1.23e-8 Diabetic kidney disease; CESC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg11965913 chr1:205819406 PM20D1 -0.8 -13.64 -0.64 1.83e-32 Menarche (age at onset); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05993306 chr5:137090649 HNRNPA0 -0.45 -6.01 -0.35 6.07e-9 Asthma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05712507 chr12:110905729 GPN3;C12orf24 0.43 6.09 0.35 3.94e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg04553112 chr3:125709451 NA -0.47 -5.31 -0.31 2.28e-7 Blood pressure (smoking interaction); CESC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.69 0.38 1.3e-10 Bipolar disorder; CESC cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.38 0.61 4.36e-28 Colonoscopy-negative controls vs population controls; CESC cis rs1316952 0.831 rs78985577 chr12:124393117 G/A cg00084347 chr12:124393913 DNAH10 0.42 6.67 0.38 1.49e-10 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs2795502 1.000 rs1581702 chr10:43344246 G/A cg20628663 chr10:43360327 NA 0.61 7.22 0.41 5.62e-12 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22333733 chr11:31391482 DNAJC24;DCDC1 -0.51 -6.31 -0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg05347473 chr6:146136440 FBXO30 -0.59 -7.65 -0.43 3.71e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs34779708 0.966 rs11010122 chr10:35493518 A/C cg04310649 chr10:35416472 CREM -0.52 -6.26 -0.36 1.54e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22805491 chr14:51172404 NA -0.53 -6.45 -0.37 5.42e-10 Gut microbiome composition (summer); CESC cis rs28829049 0.508 rs4578242 chr1:19391565 G/C cg13387374 chr1:19411106 UBR4 0.42 5.14 0.3 5.46e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg24549020 chr5:56110836 MAP3K1 0.67 7.46 0.42 1.23e-12 Initial pursuit acceleration; CESC cis rs12681366 0.708 rs3019154 chr8:95446508 C/T cg13257157 chr8:95487014 RAD54B 0.38 5.14 0.3 5.25e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs7839040 0.648 rs4341126 chr8:82922335 T/C cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs832540 0.866 rs832579 chr5:56164943 A/G cg14703610 chr5:56206110 C5orf35 0.48 6.24 0.36 1.71e-9 Coronary artery disease; CESC cis rs3825932 0.961 rs2870085 chr15:79234268 T/C cg25744700 chr15:79237217 CTSH 0.48 6.52 0.37 3.62e-10 Type 1 diabetes; CESC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg17971929 chr21:40555470 PSMG1 -0.87 -12.61 -0.61 6.96e-29 Cognitive function; CESC trans rs3099143 1.000 rs7178759 chr15:77143513 A/G cg18509435 chr18:59157879 CDH20 -0.52 -6.22 -0.36 1.98e-9 Recalcitrant atopic dermatitis; CESC cis rs2242073 0.660 rs11678616 chr2:209004548 C/T cg10392614 chr2:208977121 NA -0.37 -5.07 -0.3 7.43e-7 Attention deficit hyperactivity disorder; CESC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg19482086 chr6:160211437 TCP1;MRPL18 -0.71 -10.26 -0.53 5.27e-21 Age-related macular degeneration (geographic atrophy); CESC trans rs948562 0.744 rs11229468 chr11:58218773 C/A cg24637035 chr12:120445227 CCDC64 -0.5 -6.06 -0.35 4.67e-9 Lymphoma; CESC cis rs2708240 1.000 rs2538992 chr7:147579075 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.78 -0.33 2.12e-8 QT interval (drug interaction); CESC cis rs36051895 0.664 rs10974963 chr9:5101305 G/A cg02405213 chr9:5042618 JAK2 -0.54 -6.57 -0.37 2.58e-10 Pediatric autoimmune diseases; CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg18337363 chr3:52569053 NT5DC2 -0.31 -6.05 -0.35 5.05e-9 Electroencephalogram traits; CESC cis rs12135062 0.901 rs2651928 chr1:3101722 C/T cg00254258 chr1:3105189 PRDM16 -0.35 -5.22 -0.31 3.69e-7 Migraine; CESC cis rs11166927 0.562 rs4736095 chr8:140802744 T/C cg16909799 chr8:140841666 TRAPPC9 0.4 5.41 0.32 1.41e-7 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg21138405 chr5:131827807 IRF1 0.36 5.37 0.31 1.73e-7 Breast cancer;Mosquito bite size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12256311 chr17:685750 GLOD4;RNMTL1 0.53 6.43 0.37 5.84e-10 Gut microbiome composition (summer); CESC cis rs3820928 1.000 rs1835158 chr2:227763993 C/A cg05526886 chr2:227700861 RHBDD1 -0.43 -5.57 -0.32 6.14e-8 Pulmonary function; CESC cis rs7223966 1.000 rs752621 chr17:61901880 G/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.09 -0.3 6.87e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2625529 0.713 rs16956634 chr15:72552243 C/G cg16672083 chr15:72433130 SENP8 0.4 5.19 0.3 4.29e-7 Red blood cell count; CESC cis rs2624839 0.629 rs2526397 chr3:50187790 A/C cg24308560 chr3:49941425 MST1R 0.45 5.85 0.34 1.43e-8 Intelligence (multi-trait analysis); CESC cis rs9916302 0.904 rs68178216 chr17:37526241 A/C cg20243544 chr17:37824526 PNMT -0.48 -5.79 -0.34 1.96e-8 Glomerular filtration rate (creatinine); CESC cis rs4423214 1.000 rs12419334 chr11:71139472 T/C cg05163923 chr11:71159392 DHCR7 0.78 10.6 0.55 3.92e-22 Vitamin D levels; CESC trans rs1973993 0.691 rs553785 chr1:96895325 G/A cg10631902 chr5:14652156 NA 0.61 9.43 0.5 2.18e-18 Weight; CESC cis rs897080 0.516 rs1067393 chr2:44638832 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 5.97 0.34 7.74e-9 Height; CESC cis rs6987853 0.931 rs2923431 chr8:42394425 G/C cg09913449 chr8:42400586 C8orf40 0.38 5.8 0.34 1.89e-8 Mean corpuscular hemoglobin concentration; CESC cis rs7267979 1.000 rs4815412 chr20:25350325 A/G cg08601574 chr20:25228251 PYGB 0.38 5.55 0.32 6.88e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg15145296 chr3:125709740 NA -0.51 -5.35 -0.31 1.92e-7 Blood pressure (smoking interaction); CESC cis rs3820928 0.874 rs10439363 chr2:227815065 C/T cg11843606 chr2:227700838 RHBDD1 -0.49 -6.42 -0.37 6.29e-10 Pulmonary function; CESC cis rs1577917 0.771 rs2842607 chr6:86345039 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.53 -7.03 -0.4 1.71e-11 Response to antipsychotic treatment; CESC cis rs7523050 0.643 rs35860016 chr1:109404639 C/T cg08274380 chr1:109419600 GPSM2 0.85 5.82 0.34 1.74e-8 Fat distribution (HIV); CESC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg10691866 chr7:65817282 TPST1 -0.34 -5.59 -0.32 5.57e-8 Aortic root size; CESC cis rs367615 0.918 rs4270746 chr5:108876839 T/C cg17395555 chr5:108820864 NA 0.56 8.33 0.46 4.38e-15 Colorectal cancer (SNP x SNP interaction); CESC cis rs13392177 0.684 rs6720449 chr2:219080978 G/A cg00012203 chr2:219082015 ARPC2 -0.66 -8.18 -0.45 1.17e-14 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs6963495 0.818 rs73190151 chr7:105152887 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.5 -0.32 9.08e-8 Bipolar disorder (body mass index interaction); CESC cis rs4332037 0.539 rs34571717 chr7:2106855 T/C cg21782813 chr7:2030301 MAD1L1 -0.4 -5.2 -0.3 4.07e-7 Bipolar disorder; CESC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg18876405 chr7:65276391 NA -0.53 -7.22 -0.41 5.6e-12 Aortic root size; CESC cis rs5769765 1.000 rs2319458 chr22:50236306 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.47 -5.26 -0.31 2.9e-7 Schizophrenia; CESC cis rs1568889 0.838 rs3812738 chr11:28129982 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.82 13.65 0.64 1.7e-32 Bipolar disorder; CESC cis rs1801251 0.964 rs7589201 chr2:233724536 A/G cg25237894 chr2:233734115 C2orf82 -0.47 -8.29 -0.45 5.78e-15 Coronary artery disease; CESC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg18446336 chr7:2847575 GNA12 -0.34 -5.46 -0.32 1.1e-7 Height; CESC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg22823121 chr1:150693482 HORMAD1 0.45 6.31 0.36 1.17e-9 Melanoma; CESC cis rs561341 0.709 rs11542477 chr17:30185892 A/G cg19193384 chr17:30244184 NA 0.58 5.71 0.33 2.96e-8 Hip circumference adjusted for BMI; CESC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC cis rs9549260 0.755 rs7988604 chr13:41215802 G/T cg21288729 chr13:41239152 FOXO1 0.65 8.62 0.47 6.27e-16 Red blood cell count; CESC cis rs7188697 0.922 rs1549607 chr16:58583975 A/G cg02549819 chr16:58548995 SETD6 0.42 5.32 0.31 2.17e-7 QT interval; CESC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.17e-9 Menopause (age at onset); CESC cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg05283184 chr6:79620031 NA -0.43 -6.51 -0.37 3.72e-10 Intelligence (multi-trait analysis); CESC cis rs1878931 0.520 rs2015640 chr16:3465018 G/C cg02880119 chr16:3481970 NA 0.47 5.77 0.33 2.16e-8 Body mass index (adult); CESC cis rs7799006 0.606 rs12535174 chr7:2310974 C/T cg08027265 chr7:2291960 NA -0.58 -9.74 -0.51 2.4e-19 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs477692 1.000 rs580745 chr10:131414401 G/A cg05714579 chr10:131428358 MGMT 0.46 6.21 0.36 2.02e-9 Response to temozolomide; CESC cis rs9916302 0.904 rs8076546 chr17:37555403 G/A cg00129232 chr17:37814104 STARD3 0.59 7.96 0.44 5.17e-14 Glomerular filtration rate (creatinine); CESC cis rs9929218 1.000 rs11865026 chr16:68774283 A/G cg02972257 chr16:68554789 NA 0.55 6.41 0.37 6.78e-10 Colorectal cancer; CESC cis rs7631605 0.905 rs72866099 chr3:37259646 C/A cg22985146 chr3:37219077 LRRFIP2 -0.35 -5.44 -0.32 1.22e-7 Cerebrospinal P-tau181p levels; CESC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg10074409 chr1:209979377 IRF6 0.42 5.39 0.31 1.52e-7 Cleft lip with or without cleft palate; CESC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.46e-17 Gut microbiome composition (summer); CESC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg08027265 chr7:2291960 NA -0.47 -7.23 -0.41 5.26e-12 Bipolar disorder and schizophrenia; CESC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg16132339 chr22:24313637 DDTL;DDT 0.4 6.18 0.35 2.43e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs55728055 0.661 rs62237833 chr22:32012141 G/A cg01338084 chr22:32026380 PISD 1.22 8.02 0.44 3.48e-14 Age-related hearing impairment; CESC cis rs7927771 0.931 rs12361256 chr11:47910823 A/C cg18512352 chr11:47633146 NA -0.54 -8.84 -0.48 1.35e-16 Subjective well-being; CESC cis rs2070488 1.000 rs2070488 chr3:38442490 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.93 -17.4 -0.73 9.19e-46 Electrocardiographic conduction measures; CESC cis rs6060717 0.536 rs3787173 chr20:34472105 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.7 0.33 3.16e-8 Hip circumference adjusted for BMI; CESC cis rs9787249 0.915 rs6664570 chr1:40206298 G/A cg24920358 chr1:40204285 PPIE 0.43 6.51 0.37 3.85e-10 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19864416 chr19:42498173 ATP1A3 0.49 6.08 0.35 4.22e-9 Gut microbiome composition (summer); CESC cis rs4969178 0.896 rs1976704 chr17:76401318 C/T cg20026190 chr17:76395443 PGS1 0.46 7.35 0.41 2.41e-12 HDL cholesterol levels; CESC cis rs7772486 0.902 rs1125462 chr6:146417832 A/G cg05347473 chr6:146136440 FBXO30 0.47 6.51 0.37 3.85e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06474082 chr19:45579580 ZNF296 -0.41 -6.14 -0.35 2.94e-9 Gambling; CESC cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg00745463 chr17:30367425 LRRC37B -0.59 -6.19 -0.36 2.27e-9 Hip circumference adjusted for BMI; CESC cis rs6693567 0.565 rs1260408 chr1:150307270 T/G cg09579323 chr1:150459698 TARS2 0.48 6.1 0.35 3.84e-9 Migraine; CESC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Depression; CESC cis rs8002861 0.905 rs6561149 chr13:44456782 T/G cg14210620 chr13:44453864 C13orf31;CCDC122 -0.44 -5.58 -0.32 5.88e-8 Leprosy; CESC trans rs116095464 0.558 rs62347683 chr5:230331 C/T cg00938859 chr5:1591904 SDHAP3 0.61 6.74 0.38 9.82e-11 Breast cancer; CESC cis rs6831352 0.959 rs6532796 chr4:100042242 C/T cg21548116 chr4:100009993 ADH5 -0.5 -5.2 -0.3 4e-7 Alcohol dependence; CESC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg06808227 chr14:105710500 BRF1 -0.58 -6.77 -0.38 8.26e-11 Mean platelet volume;Platelet distribution width; CESC cis rs6456156 0.586 rs10946209 chr6:167480991 G/A cg07741184 chr6:167504864 NA 0.36 6.15 0.35 2.85e-9 Primary biliary cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22583711 chr7:154795321 PAXIP1;LOC202781 0.54 6.66 0.38 1.57e-10 Gut microbiome composition (summer); CESC cis rs6942407 0.546 rs7810647 chr7:86805961 C/A cg02420886 chr7:86849541 C7orf23 0.52 5.04 0.3 8.76e-7 Food allergy; CESC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg03240473 chr21:43526662 UMODL1;C21orf128 -0.54 -7.15 -0.4 8.52e-12 IgG glycosylation; CESC cis rs61931739 0.500 rs9795938 chr12:34587739 C/T cg23762105 chr12:34175262 ALG10 0.4 5.17 0.3 4.62e-7 Morning vs. evening chronotype; CESC cis rs6496667 0.510 rs7495784 chr15:91068882 T/C cg22089800 chr15:90895588 ZNF774 -0.46 -5.46 -0.32 1.07e-7 Rheumatoid arthritis; CESC cis rs2228479 0.702 rs12600047 chr16:89831630 G/A cg14709524 chr16:89940631 TCF25 0.92 6.68 0.38 1.39e-10 Skin colour saturation; CESC cis rs3733585 0.604 rs73215003 chr4:10126317 C/G cg05927159 chr4:10118984 WDR1 0.35 5.16 0.3 4.85e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs67257959 0.708 rs10412843 chr19:17198287 A/G cg16202187 chr19:17186497 HAUS8;MYO9B 0.45 5.39 0.31 1.56e-7 Selective IgA deficiency; CESC cis rs10883723 0.810 rs3781289 chr10:104244991 G/T cg22532475 chr10:104410764 TRIM8 -0.33 -5.61 -0.33 5.22e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg17372223 chr3:52568218 NT5DC2 0.44 7.19 0.4 6.44e-12 Bipolar disorder; CESC cis rs10883723 0.810 rs7917525 chr10:104246755 C/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.18 0.3 4.35e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs9828933 0.832 rs2292662 chr3:63897215 C/T cg16258503 chr3:63850278 ATXN7;THOC7 -0.76 -8.19 -0.45 1.11e-14 Type 2 diabetes; CESC cis rs6502050 0.871 rs6502051 chr17:80059332 A/C cg23985595 chr17:80112537 CCDC57 0.4 6.28 0.36 1.35e-9 Life satisfaction; CESC cis rs524023 0.914 rs80841 chr11:64437490 T/C cg07220939 chr11:64358617 SLC22A12 -0.34 -5.27 -0.31 2.86e-7 Urate levels in obese individuals; CESC cis rs2228479 0.867 rs11645970 chr16:89958118 G/A cg14709524 chr16:89940631 TCF25 0.73 5.64 0.33 4.36e-8 Skin colour saturation; CESC cis rs10129255 0.500 rs10143385 chr14:107190796 G/A cg07958169 chr14:107095056 NA -0.54 -8.29 -0.45 5.63e-15 Kawasaki disease; CESC trans rs9354308 0.933 rs10455586 chr6:66571498 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 7.96 0.44 5.21e-14 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07484403 chr19:19249270 TMEM161A 0.59 6.49 0.37 4.19e-10 Gut microbiome composition (summer); CESC cis rs6460942 0.597 rs35317839 chr7:12524397 C/A cg20607287 chr7:12443886 VWDE -0.71 -7.67 -0.43 3.19e-13 Coronary artery disease; CESC cis rs72627123 0.867 rs80083802 chr14:74456996 C/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.8 5.37 0.31 1.71e-7 Morning vs. evening chronotype; CESC cis rs2243480 1.000 rs313798 chr7:65493031 A/G cg25894440 chr7:65020034 NA -0.68 -5.84 -0.34 1.51e-8 Diabetic kidney disease; CESC cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg12365402 chr11:9010492 NRIP3 -0.4 -6.95 -0.39 2.92e-11 Hemoglobin concentration; CESC cis rs2635047 0.967 rs2571001 chr18:44665083 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.47 6.3 0.36 1.21e-9 Educational attainment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24689196 chr5:65893165 MAST4 -0.55 -6.4 -0.37 7.11e-10 Gut microbiome composition (summer); CESC cis rs6032067 0.704 rs62208390 chr20:43794844 A/C cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.46e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9329289 0.590 rs11251295 chr10:2563183 C/T cg15501526 chr10:2543763 NA 0.44 7.04 0.4 1.64e-11 Age-related hearing impairment; CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg18099408 chr3:52552593 STAB1 -0.34 -6.23 -0.36 1.84e-9 Bipolar disorder; CESC cis rs1670533 1.000 rs6812596 chr4:1069866 A/G cg04106633 chr4:1044584 NA 0.4 5.11 0.3 6.07e-7 Recombination rate (females); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26003818 chr1:231474059 C1orf124;EXOC8 -0.5 -6.04 -0.35 5.2e-9 Ulcerative colitis; CESC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg05535760 chr7:792225 HEATR2 0.97 11.19 0.57 4.78e-24 Cerebrospinal P-tau181p levels; CESC cis rs12220238 1.000 rs7907801 chr10:75976638 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.44 0.32 1.24e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg24642844 chr7:1081250 C7orf50 -0.74 -8.82 -0.48 1.53e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2637266 0.655 rs2588335 chr10:78510229 C/G cg18941641 chr10:78392320 NA 0.42 7.88 0.44 8.65e-14 Pulmonary function; CESC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.48 0.42 1.06e-12 Tonsillectomy; CESC cis rs11785400 0.612 rs10110864 chr8:143750072 A/G cg24634471 chr8:143751801 JRK 0.44 5.46 0.32 1.07e-7 Schizophrenia; CESC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg22903471 chr2:27725779 GCKR -0.54 -7.55 -0.42 6.95e-13 Total body bone mineral density; CESC cis rs950776 0.518 rs12906846 chr15:78825295 G/A cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg18446336 chr7:2847575 GNA12 -0.38 -5.78 -0.33 2.14e-8 Height; CESC cis rs11098499 0.908 rs2017057 chr4:120257711 A/G cg09307838 chr4:120376055 NA 0.91 12.84 0.62 1.14e-29 Corneal astigmatism; CESC trans rs9467711 0.606 rs9348712 chr6:26366511 T/A cg06606381 chr12:133084897 FBRSL1 -0.76 -6.82 -0.39 6.01e-11 Autism spectrum disorder or schizophrenia; CESC cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg11645453 chr3:52864694 ITIH4 -0.25 -5.11 -0.3 6.2e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs763014 0.865 rs8909 chr16:633851 T/C cg07343612 chr16:622815 PIGQ -0.54 -7.75 -0.43 1.96e-13 Height; CESC cis rs3820068 0.655 rs72645826 chr1:15889741 A/G cg18192808 chr1:15853278 DNAJC16 0.43 5.17 0.3 4.6e-7 Systolic blood pressure; CESC cis rs8070624 0.502 rs12951376 chr17:17752809 C/T cg16928487 chr17:17741425 SREBF1 -0.47 -7.38 -0.41 2e-12 Total body bone mineral density; CESC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs7267979 0.934 rs113469203 chr20:25343258 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -17.05 -0.72 1.69e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs501120 0.564 rs10899999 chr10:44690185 A/G cg09554077 chr10:44749378 NA 0.39 5.14 0.3 5.38e-7 Coronary artery disease;Coronary heart disease; CESC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg00484396 chr16:3507460 NAT15 -0.51 -9.07 -0.49 2.84e-17 Tuberculosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03426840 chr11:118661678 DDX6 -0.46 -6.66 -0.38 1.57e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05663655 chr7:107532014 DLD -0.45 -6.63 -0.38 1.86e-10 Gambling; CESC cis rs1799949 0.864 rs60309406 chr17:41435665 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.51 0.46 1.29e-15 Menopause (age at onset); CESC cis rs2806561 0.606 rs218341 chr1:23294153 G/C cg12483005 chr1:23474871 LUZP1 0.34 5.16 0.3 4.86e-7 Height; CESC cis rs920590 0.721 rs920587 chr8:19663339 C/A cg03894339 chr8:19674705 INTS10 0.62 7.15 0.4 8.58e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs6429082 0.818 rs61836206 chr1:235638754 C/G cg26050004 chr1:235667680 B3GALNT2 0.62 7.86 0.43 9.85e-14 Adiposity; CESC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg07507251 chr3:52567010 NT5DC2 0.41 7.18 0.4 7.2e-12 Bipolar disorder; CESC trans rs17613427 1.000 rs72989081 chr2:142246292 C/T cg16810031 chr17:38024146 ZPBP2 -0.9 -6.25 -0.36 1.65e-9 Left ventricle systolic dysfunction; CESC cis rs2932538 0.885 rs3762335 chr1:113100548 C/T cg22162597 chr1:113214053 CAPZA1 0.57 7.11 0.4 1.1e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs8038465 0.594 rs55816897 chr15:73869767 G/T cg15420318 chr15:73925796 NPTN 0.47 6.64 0.38 1.76e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7044106 0.708 rs1324472 chr9:123375110 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 9.96 0.52 4.74e-20 Hip circumference adjusted for BMI; CESC cis rs9325144 0.555 rs6582576 chr12:38701230 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.11 -0.45 1.95e-14 Morning vs. evening chronotype; CESC cis rs2228479 0.850 rs62054611 chr16:89817017 T/C cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs11098499 0.691 rs2136911 chr4:120265859 G/A cg09307838 chr4:120376055 NA 0.76 10.03 0.52 2.87e-20 Corneal astigmatism; CESC cis rs501120 1.000 rs670056 chr10:44753375 C/T cg09554077 chr10:44749378 NA 0.52 6.89 0.39 3.96e-11 Coronary artery disease;Coronary heart disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15062189 chr2:32264818 DPY30 -0.59 -7.16 -0.4 7.92e-12 Gut microbiome composition (summer); CESC cis rs2073300 0.609 rs77908916 chr20:23405626 C/G cg16736954 chr20:23401023 NAPB 0.77 5.54 0.32 7.3e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6032067 0.929 rs17424578 chr20:43806321 A/G cg10761708 chr20:43804764 PI3 0.52 6.3 0.36 1.24e-9 Blood protein levels; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg27388036 chr4:104239655 NA 0.44 6.44 0.37 5.71e-10 Thyroid stimulating hormone; CESC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg05373962 chr22:49881684 NA -0.38 -6.7 -0.38 1.24e-10 Monocyte count;Monocyte percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18638867 chr19:42784593 NA -0.42 -6.27 -0.36 1.45e-9 Fibrinogen levels; CESC cis rs9811920 0.809 rs923472 chr3:99758029 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.45 -7.39 -0.41 1.96e-12 Axial length; CESC cis rs3862030 0.839 rs2274351 chr10:104264107 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.37 -5.22 -0.31 3.54e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.62 0.42 4.42e-13 Prudent dietary pattern; CESC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg18761221 chr20:60518478 NA -0.56 -8.4 -0.46 2.71e-15 Obesity-related traits; CESC cis rs12477438 0.520 rs13022329 chr2:99731189 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.61 0.69 2.15e-39 Chronic sinus infection; CESC cis rs7177699 0.525 rs56076311 chr15:79115120 A/G cg04896959 chr15:78267971 NA 0.32 5.08 0.3 7.14e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs10463316 0.817 rs1508772 chr5:150816561 A/C cg03212797 chr5:150827313 SLC36A1 -0.51 -6.69 -0.38 1.32e-10 Metabolite levels (Pyroglutamine); CESC cis rs4474465 0.920 rs10899535 chr11:78216237 G/A cg27205649 chr11:78285834 NARS2 0.44 5.31 0.31 2.33e-7 Alzheimer's disease (survival time); CESC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.52 -0.37 3.57e-10 Bipolar disorder; CESC cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg20607287 chr7:12443886 VWDE -0.77 -10.72 -0.55 1.7e-22 Coronary artery disease; CESC cis rs791888 0.767 rs2255684 chr10:89419971 C/T cg13926569 chr10:89418898 PAPSS2 -0.53 -7.45 -0.42 1.34e-12 Magnesium levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23885512 chr19:45515293 RELB 0.42 6.24 0.36 1.7e-9 Fibrinogen levels; CESC cis rs6591182 0.503 rs11227241 chr11:65389890 G/C cg27068330 chr11:65405492 SIPA1 -0.47 -5.6 -0.33 5.34e-8 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg18225595 chr11:63971243 STIP1 0.53 5.26 0.31 3e-7 Mean platelet volume; CESC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg17949981 chr6:28129498 ZNF389 0.39 5.21 0.3 3.83e-7 Parkinson's disease; CESC trans rs208520 0.661 rs7747492 chr6:66857788 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.93 -0.62 5.39e-30 Exhaled nitric oxide output; CESC cis rs1215050 0.791 rs592053 chr4:98732220 C/T cg05340658 chr4:99064831 C4orf37 0.51 6.56 0.37 2.89e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg00166722 chr3:10149974 C3orf24 0.47 6.02 0.35 5.95e-9 Alzheimer's disease; CESC cis rs9910055 0.529 rs615070 chr17:42176591 A/G cg13607699 chr17:42295918 UBTF 0.43 5.28 0.31 2.66e-7 Total body bone mineral density; CESC cis rs12618769 0.597 rs12622341 chr2:99074680 A/T cg10123293 chr2:99228465 UNC50 0.39 5.07 0.3 7.32e-7 Bipolar disorder; CESC cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4803468 1.000 rs10422956 chr19:41901261 C/T cg14132834 chr19:41945861 ATP5SL -0.63 -7.84 -0.43 1.12e-13 Height; CESC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.69 5.71 0.33 2.96e-8 Platelet count; CESC cis rs3824867 0.920 rs7126210 chr11:47460306 A/G cg20307385 chr11:47447363 PSMC3 0.5 5.96 0.34 7.83e-9 Mean corpuscular hemoglobin; CESC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 8.03 0.44 3.21e-14 Platelet count; CESC cis rs9287719 0.967 rs715246 chr2:10736355 G/A cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs12612435 0.554 rs35820061 chr2:137064885 C/T cg23554286 chr2:137951070 THSD7B 0.63 5.13 0.3 5.59e-7 Takotsubo syndrome; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg24816464 chr3:86061715 CADM2 -0.45 -6.03 -0.35 5.59e-9 Bronchopulmonary dysplasia; CESC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg25767906 chr1:53392781 SCP2 0.43 6.02 0.35 5.86e-9 Monocyte count; CESC cis rs9929218 1.000 rs12448448 chr16:68802516 T/G cg02972257 chr16:68554789 NA 0.43 5.22 0.31 3.65e-7 Colorectal cancer; CESC trans rs11098499 0.754 rs1511017 chr4:120250805 G/A cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs1801251 0.752 rs2675966 chr2:233735543 T/C cg25237894 chr2:233734115 C2orf82 -0.5 -8.72 -0.47 3.06e-16 Coronary artery disease; CESC cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg06212747 chr3:49208901 KLHDC8B 0.66 8.99 0.48 4.84e-17 Parkinson's disease; CESC cis rs6964587 0.869 rs10250014 chr7:91490208 T/C cg17063962 chr7:91808500 NA -0.53 -7.23 -0.41 5.28e-12 Breast cancer; CESC cis rs7772486 0.686 rs9373473 chr6:146082282 A/G cg23711669 chr6:146136114 FBXO30 0.79 11.4 0.57 8.94e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs938554 0.513 rs10939650 chr4:9998440 C/T cg02734326 chr4:10020555 SLC2A9 0.42 5.29 0.31 2.58e-7 Blood metabolite levels; CESC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.07 0.3 7.62e-7 Menopause (age at onset); CESC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg03806693 chr22:41940476 POLR3H -1.23 -16.62 -0.71 5.48e-43 Vitiligo; CESC cis rs28374715 0.635 rs112547435 chr15:41648737 C/G cg18705301 chr15:41695430 NDUFAF1 -0.92 -14.13 -0.66 3.48e-34 Ulcerative colitis; CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg04775059 chr7:64541387 NA 0.45 5.7 0.33 3.17e-8 Calcium levels; CESC cis rs7084402 0.967 rs1649062 chr10:60309326 G/A cg07615347 chr10:60278583 BICC1 0.59 9.34 0.5 4.21e-18 Refractive error; CESC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg12463550 chr7:65579703 CRCP 0.58 7.41 0.41 1.67e-12 Aortic root size; CESC cis rs861020 0.630 rs627069 chr1:210004613 C/G cg05527609 chr1:210001259 C1orf107 0.74 9.67 0.51 3.97e-19 Orofacial clefts; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17967728 chr15:52263786 LEO1 -0.52 -6.26 -0.36 1.53e-9 Ulcerative colitis; CESC cis rs9611565 0.921 rs761366 chr22:41744022 C/G cg03806693 chr22:41940476 POLR3H -0.97 -10.9 -0.56 4.3e-23 Vitiligo; CESC cis rs2243480 1.000 rs316318 chr7:65612904 A/G cg13147721 chr7:65941812 NA -0.97 -9.14 -0.49 1.7e-17 Diabetic kidney disease; CESC cis rs9487051 0.737 rs1260593 chr6:109521400 C/T cg01475377 chr6:109611718 NA -0.46 -6.93 -0.39 3.18e-11 Reticulocyte fraction of red cells; CESC cis rs4629180 0.675 rs4851459 chr2:102109006 T/A cg21388029 chr2:102003306 CREG2 0.31 5.21 0.3 3.84e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs796364 1.000 rs281759 chr2:200787719 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.86 8.24 0.45 8e-15 Schizophrenia; CESC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.43 -0.42 1.45e-12 Total body bone mineral density; CESC cis rs10911232 0.507 rs4652762 chr1:182993960 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg09365446 chr1:150670422 GOLPH3L 0.4 5.26 0.31 3.03e-7 Melanoma; CESC cis rs61841072 0.961 rs10803104 chr1:243126037 T/C cg02356786 chr1:243265016 LOC731275 0.4 5.04 0.3 8.48e-7 Schizophrenia; CESC cis rs28647808 1.000 rs2285484 chr9:136271841 C/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs933688 0.759 rs1423593 chr5:90752351 T/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 9.76 0.51 2.08e-19 Smoking behavior; CESC cis rs6831352 0.918 rs29001216 chr4:100051556 A/T cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs7264396 0.563 rs11698796 chr20:34248134 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -9.76 -0.51 2.07e-19 Total cholesterol levels; CESC cis rs9811920 0.732 rs7613864 chr3:99602470 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 7.72 0.43 2.44e-13 Axial length; CESC cis rs787274 0.867 rs1711744 chr9:115453484 A/T cg13803584 chr9:115635662 SNX30 -0.53 -5.37 -0.31 1.72e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Tonsillectomy; CESC cis rs12142240 0.698 rs55670684 chr1:46835139 C/T cg00530320 chr1:46809349 NSUN4 0.63 8.16 0.45 1.33e-14 Menopause (age at onset); CESC cis rs752010 0.619 rs10736421 chr1:42106230 G/A cg06885757 chr1:42089581 HIVEP3 0.65 10.26 0.53 5.33e-21 Lupus nephritis in systemic lupus erythematosus; CESC cis rs5769765 0.862 rs138870 chr22:50209737 C/T cg02269571 chr22:50332266 NA -0.46 -5.89 -0.34 1.17e-8 Schizophrenia; CESC cis rs11792861 0.926 rs11788825 chr9:111829757 T/G cg13535736 chr9:111863775 C9orf5 -0.46 -6.32 -0.36 1.1e-9 Menarche (age at onset); CESC cis rs10911232 0.507 rs10797833 chr1:183044067 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 13.3 0.63 2.92e-31 Hypertriglyceridemia; CESC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.51 -0.32 8.53e-8 Lung cancer; CESC cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs17655565 0.904 rs3809172 chr12:52695198 G/C cg08257133 chr12:52711352 KRT83 0.51 5.74 0.33 2.65e-8 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs7833986 0.501 rs17815934 chr8:57038395 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 7e-13 Height; CESC cis rs9549367 0.577 rs3024718 chr13:113813853 C/T cg00898013 chr13:113819073 PROZ 0.45 6.12 0.35 3.33e-9 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19556901 chr15:25414769 SNORD115-1 -0.52 -6.64 -0.38 1.74e-10 Gut microbiome composition (summer); CESC cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg21017887 chr14:105400489 NA 0.42 6.83 0.39 5.93e-11 Rheumatoid arthritis; CESC cis rs7084402 0.967 rs7094882 chr10:60276829 C/T cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.9e-18 Refractive error; CESC cis rs2425143 1.000 rs2425078 chr20:34298163 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -8.05 -0.44 2.8e-14 Blood protein levels; CESC cis rs3768617 0.510 rs12061219 chr1:183101471 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs9291683 0.546 rs13139055 chr4:10038924 G/T cg11266682 chr4:10021025 SLC2A9 0.66 12.46 0.61 2.27e-28 Bone mineral density; CESC cis rs244293 0.831 rs11079147 chr17:53094754 G/A cg19360675 chr17:53046073 COX11;STXBP4 0.4 5.11 0.3 6.18e-7 Menarche (age at onset); CESC cis rs7107174 0.681 rs3102742 chr11:77949334 G/T cg02023728 chr11:77925099 USP35 0.54 6.82 0.39 6.19e-11 Testicular germ cell tumor; CESC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg19468946 chr17:37922297 IKZF3 -0.42 -5.31 -0.31 2.3e-7 Asthma; CESC trans rs453301 0.571 rs330057 chr8:9089793 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -6.79 -0.38 7.49e-11 Joint mobility (Beighton score); CESC cis rs6088580 0.634 rs6059897 chr20:33113224 A/G cg06115741 chr20:33292138 TP53INP2 0.44 5.59 0.32 5.74e-8 Glomerular filtration rate (creatinine); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25355645 chr19:42873746 MEGF8 0.44 6.37 0.36 8.39e-10 Fibrinogen levels; CESC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg24250549 chr1:154909240 PMVK 0.74 11.08 0.56 1.06e-23 Prostate cancer; CESC cis rs6674970 0.518 rs15740 chr1:151040435 G/A cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.44 -5.18 -0.3 4.31e-7 Childhood ear infection; CESC trans rs11992162 0.967 rs7836456 chr8:11829175 T/G cg15556689 chr8:8085844 FLJ10661 0.55 6.53 0.37 3.39e-10 Monocyte count; CESC cis rs67478160 0.643 rs2295141 chr14:104212949 T/C cg08213375 chr14:104286397 PPP1R13B 0.54 10.89 0.56 4.58e-23 Schizophrenia; CESC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg11890956 chr21:40555474 PSMG1 -0.95 -15.5 -0.69 5.28e-39 Cognitive function; CESC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg16680214 chr1:154839983 KCNN3 -0.45 -6.88 -0.39 4.19e-11 Prostate cancer; CESC cis rs1808579 0.935 rs7239575 chr18:21120035 C/T cg14672496 chr18:21087552 C18orf8 -0.42 -6.39 -0.37 7.32e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg00750074 chr16:89608354 SPG7 -0.43 -6.26 -0.36 1.54e-9 Multiple myeloma (IgH translocation); CESC cis rs13191362 0.507 rs2023015 chr6:163060528 A/T cg21926612 chr6:163149169 PACRG;PARK2 -0.55 -6.74 -0.38 1.01e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs2727020 0.595 rs10839281 chr11:49483373 A/C cg15704280 chr7:45808275 SEPT13 -0.94 -16.68 -0.72 3.31e-43 Coronary artery disease; CESC cis rs10208940 0.920 rs7576303 chr2:68838019 G/A cg12452813 chr2:68675892 NA 0.52 5.18 0.3 4.48e-7 Urate levels in lean individuals; CESC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg02034447 chr16:89574710 SPG7 -0.47 -6.04 -0.35 5.27e-9 Multiple myeloma (IgH translocation); CESC cis rs7219021 1.000 rs68012338 chr17:46856405 G/A cg16584676 chr17:46985605 UBE2Z -0.56 -6.32 -0.36 1.08e-9 Schizophrenia or bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23962285 chr1:108743536 SLC25A24 0.46 6.38 0.36 7.79e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4253772 0.530 rs9615989 chr22:46803774 A/T cg00784671 chr22:46762841 CELSR1 -0.77 -6.06 -0.35 4.76e-9 LDL cholesterol;Cholesterol, total; CESC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg06713675 chr4:122721982 EXOSC9 -0.51 -6.99 -0.39 2.2e-11 Type 2 diabetes; CESC cis rs3733585 0.664 rs28602527 chr4:9958327 G/A cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg18876405 chr7:65276391 NA 0.45 6.08 0.35 4.15e-9 Aortic root size; CESC cis rs1215050 0.791 rs2695472 chr4:98855127 T/C cg05340658 chr4:99064831 C4orf37 -0.5 -6.59 -0.38 2.32e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs6939532 0.522 rs4712980 chr6:26355758 G/T cg14345882 chr6:26364793 BTN3A2 -0.38 -5.87 -0.34 1.27e-8 Autism spectrum disorder or schizophrenia; CESC cis rs17376456 0.825 rs10054903 chr5:93281491 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.67 5.51 0.32 8.46e-8 Diabetic retinopathy; CESC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg18769074 chr3:133464867 TF 0.32 5.93 0.34 9.22e-9 Iron status biomarkers; CESC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.48e-10 Depression; CESC cis rs2070997 0.667 rs12156431 chr9:133719540 A/G cg11464064 chr9:133710261 ABL1 0.66 7.42 0.41 1.62e-12 Response to amphetamines; CESC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.15 -0.3 5.05e-7 Breast cancer; CESC cis rs17854409 0.803 rs1063246 chr20:61472116 G/A cg07645718 chr20:61493192 TCFL5 0.79 5.2 0.3 4.02e-7 Obesity-related traits; CESC cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg07636037 chr3:49044803 WDR6 1.08 19.66 0.77 1.06e-53 Parkinson's disease; CESC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg25072359 chr17:41440525 NA 0.49 7.18 0.4 7.06e-12 Menopause (age at onset); CESC cis rs6582630 0.555 rs2090785 chr12:38424342 G/A cg26384229 chr12:38710491 ALG10B 0.69 10.55 0.54 5.83e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs7726839 0.540 rs12517638 chr5:645484 C/T cg16447950 chr5:562315 NA -0.58 -6.53 -0.37 3.38e-10 Obesity-related traits; CESC trans rs10506458 0.834 rs73125186 chr12:63373400 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.3 -17.22 -0.73 4.04e-45 Hemostatic factors and hematological phenotypes; CESC cis rs7474896 0.583 rs7071147 chr10:38003376 T/C cg00409905 chr10:38381863 ZNF37A -0.48 -5.59 -0.32 5.65e-8 Obesity (extreme); CESC cis rs4654899 0.865 rs10916951 chr1:21528835 A/G cg05370193 chr1:21551575 ECE1 -0.45 -7.0 -0.4 2.06e-11 Superior frontal gyrus grey matter volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06886078 chr10:126480477 METTL10 -0.46 -6.25 -0.36 1.6e-9 Fibrinogen levels; CESC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg12311346 chr5:56204834 C5orf35 -0.74 -8.75 -0.47 2.61e-16 Initial pursuit acceleration; CESC cis rs933688 0.583 rs6882172 chr5:90576958 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.48 -5.38 -0.31 1.64e-7 Smoking behavior; CESC cis rs79349575 0.783 rs59270107 chr17:47026185 A/T cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs962856 1.000 rs11888062 chr2:67605358 C/A cg09028215 chr2:67624308 ETAA1 -0.42 -5.52 -0.32 8.03e-8 Pancreatic cancer; CESC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg06873352 chr17:61820015 STRADA 0.74 13.03 0.62 2.6e-30 Prudent dietary pattern; CESC cis rs9513627 0.512 rs9517759 chr13:100180108 T/G cg15490075 chr13:100150979 NA 0.48 5.22 0.31 3.59e-7 Obesity-related traits; CESC cis rs7949030 0.588 rs2428549 chr11:62312394 A/G cg22862634 chr11:62369728 EML3;MTA2 0.48 6.74 0.38 9.6e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs3820068 0.603 rs7531396 chr1:15969870 G/C cg18133145 chr1:16060689 PLEKHM2 -0.4 -5.07 -0.3 7.37e-7 Systolic blood pressure; CESC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs7089973 0.872 rs36036948 chr10:116631649 A/G cg25233709 chr10:116636983 FAM160B1 0.34 5.03 0.3 8.89e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4450798 0.649 rs6806000 chr3:13779211 C/T cg23332027 chr3:13681764 NA 0.4 5.59 0.32 5.77e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs16854884 0.632 rs60505453 chr3:143643864 C/G cg06585982 chr3:143692056 C3orf58 0.54 7.1 0.4 1.15e-11 Economic and political preferences (feminism/equality); CESC cis rs9300255 0.770 rs12299125 chr12:123862447 C/T cg19016782 chr12:123741754 C12orf65 0.46 6.33 0.36 1.04e-9 Neutrophil percentage of white cells; CESC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.42 -0.32 1.31e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs6545883 0.868 rs778755 chr2:61781037 A/G cg15711740 chr2:61764176 XPO1 0.39 5.1 0.3 6.63e-7 Tuberculosis; CESC cis rs4737010 0.570 rs10112594 chr8:41645565 C/T cg08923054 chr8:41654455 ANK1 0.53 6.67 0.38 1.51e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs367615 0.506 rs246102 chr5:108699695 C/G cg17395555 chr5:108820864 NA -0.44 -7.13 -0.4 9.39e-12 Colorectal cancer (SNP x SNP interaction); CESC cis rs9399135 0.967 rs6910530 chr6:135332770 C/T cg24558204 chr6:135376177 HBS1L 0.54 7.47 0.42 1.19e-12 Red blood cell count; CESC cis rs644799 0.735 rs10831432 chr11:95516040 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.8 0.59 4.17e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4746818 1.000 rs4746817 chr10:70882515 T/C cg11621586 chr10:70884670 VPS26A 0.86 8.53 0.46 1.15e-15 Left atrial antero-posterior diameter; CESC cis rs9916302 0.861 rs12150493 chr17:37586154 T/C cg00129232 chr17:37814104 STARD3 -0.56 -7.35 -0.41 2.4e-12 Glomerular filtration rate (creatinine); CESC cis rs16866061 0.515 rs11695326 chr2:225415134 A/G cg12698349 chr2:225449008 CUL3 0.84 15.12 0.68 1.11e-37 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg12311346 chr5:56204834 C5orf35 -0.74 -8.94 -0.48 6.7e-17 Initial pursuit acceleration; CESC cis rs11098499 0.909 rs35111518 chr4:120440682 A/G cg09307838 chr4:120376055 NA 0.92 12.5 0.61 1.73e-28 Corneal astigmatism; CESC cis rs3845702 0.736 rs16867131 chr2:180848651 A/G cg01881094 chr2:180872142 CWC22 -1.05 -9.02 -0.48 3.86e-17 Schizophrenia; CESC trans rs10772915 0.739 rs1799497 chr12:16399551 T/C cg26946092 chr2:236139863 NA -0.37 -6.01 -0.35 6.15e-9 Visceral fat; CESC cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg20476274 chr7:133979776 SLC35B4 0.61 8.39 0.46 2.93e-15 Mean platelet volume; CESC cis rs9388451 0.839 rs980014 chr6:126068001 T/G cg05901451 chr6:126070800 HEY2 -0.64 -9.03 -0.48 3.73e-17 Brugada syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10719100 chr8:146078187 COMMD5 0.61 7.29 0.41 3.61e-12 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs75936910 chr14:56149351 T/C cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg23711669 chr6:146136114 FBXO30 -1.0 -15.4 -0.69 1.15e-38 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06339974 chr13:20437949 ZMYM5 0.59 6.49 0.37 4.3e-10 Gut microbiome composition (summer); CESC cis rs4319547 0.915 rs10734924 chr12:123018894 T/G cg23029597 chr12:123009494 RSRC2 -0.5 -5.5 -0.32 8.83e-8 Body mass index; CESC cis rs12142240 0.698 rs68191463 chr1:46808695 T/C cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs116988415 0.584 rs4902313 chr14:65242164 T/C cg25083366 chr14:65239357 SPTB 0.69 5.05 0.3 8.39e-7 Daytime sleep phenotypes; CESC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg18252515 chr7:66147081 NA -0.45 -5.88 -0.34 1.22e-8 Aortic root size; CESC cis rs4812048 0.895 rs236691 chr20:57583536 G/C cg14073986 chr20:57617431 SLMO2 0.62 5.87 0.34 1.32e-8 Mean platelet volume; CESC trans rs7246657 0.943 rs6508733 chr19:38000548 A/T cg01833234 chr11:6592585 DNHD1 0.51 6.18 0.35 2.37e-9 Coronary artery calcification; CESC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 5.62 0.33 4.72e-8 Menopause (age at onset); CESC trans rs9467711 0.584 rs34244947 chr6:26761745 T/C cg01620082 chr3:125678407 NA -0.74 -6.32 -0.36 1.11e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg08499158 chr17:42289980 UBTF -0.5 -6.36 -0.36 8.78e-10 Total body bone mineral density; CESC trans rs1493916 0.905 rs10460051 chr18:31413679 C/T cg27147174 chr7:100797783 AP1S1 -0.53 -6.83 -0.39 5.73e-11 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20476274 chr7:133979776 SLC35B4 -0.56 -6.03 -0.35 5.39e-9 Gut microbiome composition (summer); CESC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg16049864 chr8:95962084 TP53INP1 -0.67 -12.13 -0.6 3.13e-27 Type 2 diabetes; CESC cis rs3126085 0.935 rs7550106 chr1:152197202 C/T cg03465714 chr1:152285911 FLG 0.43 5.48 0.32 9.96e-8 Atopic dermatitis; CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg05564831 chr3:52568323 NT5DC2 0.48 8.11 0.45 1.83e-14 Bipolar disorder; CESC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg08888203 chr3:10149979 C3orf24 0.46 5.84 0.34 1.5e-8 Alzheimer's disease; CESC cis rs4889855 0.556 rs9911795 chr17:78626115 T/C cg09596252 chr17:78655493 RPTOR 0.42 5.09 0.3 6.68e-7 Fractional excretion of uric acid; CESC trans rs11098499 0.754 rs10006259 chr4:120242145 C/T cg25214090 chr10:38739885 LOC399744 0.61 8.47 0.46 1.73e-15 Corneal astigmatism; CESC cis rs1413885 0.516 rs716592 chr1:65843982 C/T cg14976592 chr1:65886160 LEPROT;LEPR -0.51 -6.58 -0.37 2.47e-10 Anticoagulant levels; CESC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg11494091 chr17:61959527 GH2 0.73 12.49 0.61 1.88e-28 Prudent dietary pattern; CESC cis rs7084402 1.000 rs11006169 chr10:60269326 T/A cg07615347 chr10:60278583 BICC1 -0.57 -8.71 -0.47 3.43e-16 Refractive error; CESC cis rs9916302 0.904 rs11654018 chr17:37703740 C/T cg07936489 chr17:37558343 FBXL20 0.8 11.58 0.58 2.37e-25 Glomerular filtration rate (creatinine); CESC cis rs873946 0.504 rs12775990 chr10:134575836 C/T cg26818010 chr10:134567672 INPP5A -0.91 -11.18 -0.57 5.13e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7481584 0.517 rs80872 chr11:3049984 G/T cg25174290 chr11:3078921 CARS -0.45 -6.28 -0.36 1.36e-9 Calcium levels; CESC cis rs12477438 0.501 rs11688004 chr2:99735052 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 13.0 0.62 3.21e-30 Chronic sinus infection; CESC cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg19717773 chr7:2847554 GNA12 -0.66 -11.58 -0.58 2.34e-25 Height; CESC cis rs36051895 0.659 rs7036476 chr9:5063664 T/C cg02405213 chr9:5042618 JAK2 -0.46 -5.75 -0.33 2.45e-8 Pediatric autoimmune diseases; CESC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg05564831 chr3:52568323 NT5DC2 0.44 6.63 0.38 1.92e-10 Bipolar disorder; CESC cis rs2243480 1.000 rs431076 chr7:65600320 A/C cg12463550 chr7:65579703 CRCP 0.74 5.75 0.33 2.4e-8 Diabetic kidney disease; CESC cis rs6460942 1.000 rs2053378 chr7:12405564 C/G cg20607287 chr7:12443886 VWDE -0.79 -8.72 -0.47 3.1e-16 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00500481 chr6:36562387 SFRS3 0.62 7.07 0.4 1.39e-11 Gut microbiome composition (summer); CESC cis rs11958404 0.932 rs72816566 chr5:157427613 G/A cg05962755 chr5:157440814 NA 0.59 6.45 0.37 5.28e-10 IgG glycosylation; CESC cis rs7107174 1.000 rs10899483 chr11:78061057 G/C cg02023728 chr11:77925099 USP35 0.38 5.4 0.31 1.47e-7 Testicular germ cell tumor; CESC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg03188948 chr7:1209495 NA 0.49 5.81 0.34 1.8e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6460942 0.915 rs6965564 chr7:12306013 C/T cg06484146 chr7:12443880 VWDE -0.41 -5.68 -0.33 3.61e-8 Coronary artery disease; CESC cis rs7103648 0.643 rs12365079 chr11:47696596 A/T cg20307385 chr11:47447363 PSMC3 0.82 12.41 0.61 3.41e-28 Diastolic blood pressure;Systolic blood pressure; CESC cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg23711669 chr6:146136114 FBXO30 -1.01 -15.6 -0.69 2.22e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg11764359 chr7:65958608 NA -0.74 -10.23 -0.53 6.36e-21 Aortic root size; CESC cis rs6690583 0.524 rs12029690 chr1:85452867 C/G cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs13242816 1.000 rs35800921 chr7:116124041 G/A cg04696780 chr7:116139425 CAV2 -0.58 -5.21 -0.3 3.79e-7 P wave duration; CESC cis rs13191362 0.507 rs2849520 chr6:163132038 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.66 -7.64 -0.42 3.99e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2404602 0.692 rs35195096 chr15:76938447 C/T cg26408565 chr15:76604113 ETFA -0.4 -5.68 -0.33 3.45e-8 Blood metabolite levels; CESC cis rs9612 0.950 rs346546 chr19:44256910 T/C cg08581076 chr19:44259116 C19orf61 0.52 6.19 0.36 2.33e-9 Exhaled nitric oxide output; CESC cis rs9435341 0.965 rs61798468 chr1:107569316 T/G cg09367891 chr1:107599246 PRMT6 0.72 8.38 0.46 3.06e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -7.89 -0.44 8.05e-14 Personality dimensions; CESC cis rs600231 0.706 rs10896016 chr11:65335705 C/T cg21890820 chr11:65308645 LTBP3 -0.41 -5.19 -0.3 4.14e-7 Bone mineral density; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04827747 chr7:134855666 C7orf49 -0.48 -6.22 -0.36 1.95e-9 Asthma; CESC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg22800045 chr5:56110881 MAP3K1 -0.76 -8.67 -0.47 4.42e-16 Initial pursuit acceleration; CESC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.46 0.37 4.98e-10 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12095067 chr19:9929835 FBXL12 -0.41 -6.02 -0.35 5.81e-9 Gambling; CESC cis rs6087990 0.835 rs4911106 chr20:31331330 A/G cg13636640 chr20:31349939 DNMT3B 0.84 14.79 0.67 1.67e-36 Ulcerative colitis; CESC cis rs71403859 0.502 rs8053720 chr16:71456142 C/G cg08717414 chr16:71523259 ZNF19 -0.81 -8.02 -0.44 3.47e-14 Post bronchodilator FEV1; CESC cis rs1707322 1.000 rs785484 chr1:46574015 T/C cg05343316 chr1:45956843 TESK2 -0.47 -5.52 -0.32 7.97e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs10776614 0.799 rs1838568 chr10:49763690 G/C cg19218067 chr2:181235115 NA 0.5 6.1 0.35 3.7e-9 Self-employment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02615117 chr20:36034986 NA -0.55 -6.86 -0.39 4.88e-11 Gut microbiome composition (summer); CESC cis rs611744 0.647 rs1609472 chr8:109269232 T/G cg21045802 chr8:109455806 TTC35 0.5 6.25 0.36 1.62e-9 Dupuytren's disease; CESC cis rs113601626 1 rs113601626 chr2:24239189 T/TCCTGGC cg20701182 chr2:24300061 SF3B14 0.82 6.96 0.39 2.66e-11 Lymphocyte percentage of white cells; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg27277367 chr15:100106179 MEF2A -0.46 -6.0 -0.35 6.36e-9 Recombination measurement; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00026230 chr16:30064606 ALDOA 0.71 8.32 0.46 4.67e-15 Gut microbiome composition (summer); CESC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg16325326 chr1:53192061 ZYG11B -1.01 -17.88 -0.74 1.89e-47 Monocyte count; CESC cis rs58785573 1.000 rs58785573 chr4:38653773 A/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.49 6.27 0.36 1.48e-9 Lymphocyte percentage of white cells; CESC cis rs12142240 0.698 rs79490411 chr1:46813568 G/A cg10495392 chr1:46806563 NSUN4 0.56 5.83 0.34 1.64e-8 Menopause (age at onset); CESC cis rs8020095 0.571 rs3784078 chr14:67559710 G/C cg19548862 chr14:67692701 FAM71D -0.48 -5.84 -0.34 1.5e-8 Depression (quantitative trait); CESC cis rs41298997 1 rs41298997 chr1:206655331 C/T cg11166312 chr1:206654246 IKBKE 0.54 7.35 0.41 2.49e-12 Psoriasis; CESC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg18032046 chr6:28092343 ZSCAN16 -0.48 -6.04 -0.35 5.19e-9 Cardiac Troponin-T levels; CESC cis rs7957207 0.571 rs1169076 chr12:122429484 G/A cg22168489 chr12:122356033 WDR66 -0.38 -5.12 -0.3 5.94e-7 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CESC cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg27478167 chr7:817139 HEATR2 -0.48 -5.25 -0.31 3.11e-7 Cerebrospinal P-tau181p levels; CESC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg08859206 chr1:53392774 SCP2 0.52 6.88 0.39 4.34e-11 Monocyte count; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg13118410 chr11:49839281 NA 0.52 6.46 0.37 5.01e-10 Subjective well-being; CESC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg12379764 chr21:47803548 PCNT 0.52 6.36 0.36 8.99e-10 Testicular germ cell tumor; CESC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg01238044 chr22:24384105 GSTT1 0.5 6.11 0.35 3.47e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs11792861 0.962 rs72607161 chr9:111792640 T/C cg14384093 chr9:111878565 C9orf5 -0.41 -5.09 -0.3 6.73e-7 Menarche (age at onset); CESC cis rs116095464 1.000 rs6873902 chr5:313337 C/G cg10591111 chr5:226296 SDHA -0.63 -5.89 -0.34 1.16e-8 Breast cancer; CESC cis rs1707322 1.000 rs12077974 chr1:46384141 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.44 0.32 1.22e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1569419 1.000 rs1569419 chr1:2996602 C/T cg00806481 chr1:2996650 PRDM16 0.38 5.9 0.34 1.13e-8 Mean corpuscular volume;Mean corpuscular hemoglobin;Plateletcrit;Platelet distribution width;Mean platelet volume;Red blood cell count; CESC cis rs929354 1.000 rs1182452 chr7:157053618 G/A cg05182265 chr7:156933206 UBE3C 0.44 6.05 0.35 4.99e-9 Body mass index; CESC cis rs26868 0.742 rs26848 chr16:2263516 A/G cg07587117 chr16:2239488 CASKIN1 0.42 7.16 0.4 8.17e-12 Height; CESC trans rs3780486 0.713 rs3780489 chr9:33129844 G/T cg04842962 chr6:43655489 MRPS18A 1.01 19.68 0.77 9.13e-54 IgG glycosylation; CESC cis rs4843747 0.519 rs12599755 chr16:88107006 A/G cg06915872 chr16:87998081 BANP 0.44 5.27 0.31 2.78e-7 Menopause (age at onset); CESC cis rs4722166 0.630 rs7781534 chr7:22778592 A/C cg05265849 chr7:22767390 IL6 0.57 7.11 0.4 1.06e-11 Lung cancer; CESC cis rs2243480 1.000 rs316331 chr7:65604622 A/G cg18252515 chr7:66147081 NA 1.38 14.16 0.66 2.93e-34 Diabetic kidney disease; CESC cis rs17818399 0.684 rs62134759 chr2:46791849 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.55 -5.92 -0.34 1e-8 Height; CESC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.54 0.37 3.07e-10 Prudent dietary pattern; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19853194 chr18:9913725 VAPA 0.47 6.67 0.38 1.45e-10 Systemic lupus erythematosus; CESC cis rs7084402 0.935 rs11006192 chr10:60343638 T/C cg07615347 chr10:60278583 BICC1 0.55 8.35 0.46 3.86e-15 Refractive error; CESC cis rs9303280 0.901 rs2313430 chr17:37929816 T/C cg20243544 chr17:37824526 PNMT -0.49 -6.74 -0.38 1.01e-10 Self-reported allergy; CESC cis rs3091242 0.933 rs28633797 chr1:25741629 C/A cg27572855 chr1:25598939 RHD 0.43 7.14 0.4 8.75e-12 Erythrocyte sedimentation rate; CESC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg00745463 chr17:30367425 LRRC37B 0.57 5.64 0.33 4.28e-8 Hip circumference adjusted for BMI; CESC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.18 0.53 9.01e-21 Mean platelet volume; CESC trans rs4596713 0.538 rs11145460 chr9:71766091 T/G cg16512924 chr15:28394682 HERC2 0.5 6.38 0.36 7.96e-10 Headache; CESC cis rs10791097 0.653 rs11222362 chr11:130731425 T/C cg12179176 chr11:130786555 SNX19 0.56 8.16 0.45 1.36e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1707322 0.752 rs4660313 chr1:46110841 A/G cg05343316 chr1:45956843 TESK2 -0.49 -6.11 -0.35 3.55e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs10009206 chr4:99056900 A/C cg05340658 chr4:99064831 C4orf37 -0.6 -8.55 -0.46 1.01e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7107174 1.000 rs10899456 chr11:78000155 C/G cg02023728 chr11:77925099 USP35 0.44 6.09 0.35 3.93e-9 Testicular germ cell tumor; CESC cis rs7107174 0.892 rs2090095 chr11:78034020 G/A cg02023728 chr11:77925099 USP35 0.41 5.9 0.34 1.09e-8 Testicular germ cell tumor; CESC trans rs7618501 0.602 rs2071207 chr3:50159844 T/C cg21659725 chr3:3221576 CRBN -0.48 -6.58 -0.37 2.5e-10 Intelligence (multi-trait analysis); CESC cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg14584255 chr6:163149320 PACRG;PARK2 -0.51 -5.76 -0.33 2.31e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4242434 0.854 rs11782130 chr8:22452357 G/T cg03733263 chr8:22462867 KIAA1967 0.88 13.83 0.65 4.23e-33 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs9911578 1.000 rs302854 chr17:56683612 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC trans rs17635075 0.590 rs57971645 chr4:167156182 G/A cg11354629 chr13:28366598 GSX1 -0.56 -6.13 -0.35 3.2e-9 Obesity-related traits; CESC cis rs10791097 0.667 rs1893019 chr11:130756664 C/G cg09137382 chr11:130731461 NA 0.36 5.33 0.31 2.12e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg00031303 chr3:195681400 NA 0.47 5.89 0.34 1.19e-8 Pancreatic cancer; CESC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg11247378 chr22:39784982 NA -0.52 -7.97 -0.44 4.7e-14 Intelligence (multi-trait analysis); CESC cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg00031303 chr3:195681400 NA 0.45 5.65 0.33 4.21e-8 Pancreatic cancer; CESC cis rs17826219 0.636 rs2449770 chr17:29101064 G/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Body mass index; CESC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg11764359 chr7:65958608 NA 0.96 15.25 0.68 3.95e-38 Aortic root size; CESC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg07701084 chr6:150067640 NUP43 0.47 6.63 0.38 1.87e-10 Lung cancer; CESC cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg12386194 chr3:101231763 SENP7 0.42 5.28 0.31 2.72e-7 Colorectal cancer; CESC cis rs7246657 0.943 rs8109632 chr19:37931125 A/T cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.69e-9 Coronary artery calcification; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27507545 chr10:103880405 LDB1 -0.43 -6.14 -0.35 3.01e-9 Gambling; CESC cis rs28829049 0.861 rs28631243 chr1:19350083 T/C cg13387374 chr1:19411106 UBR4 0.41 5.07 0.3 7.41e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09224523 chr1:206808529 DYRK3 -0.52 -6.1 -0.35 3.65e-9 Gut microbiome composition (summer); CESC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg22968622 chr17:43663579 NA 1.32 17.92 0.74 1.34e-47 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg06022373 chr22:39101656 GTPBP1 0.89 14.32 0.66 7.5e-35 Menopause (age at onset); CESC cis rs7843479 0.965 rs733544 chr8:21835628 A/G cg17168535 chr8:21777572 XPO7 0.51 7.2 0.4 6.27e-12 Mean corpuscular volume; CESC cis rs7692995 1.000 rs13105471 chr4:17959776 C/T cg08925142 chr4:18023851 LCORL -0.45 -5.13 -0.3 5.66e-7 Height; CESC cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg27347728 chr4:17578864 LAP3 -0.46 -5.35 -0.31 1.94e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg03352830 chr11:487213 PTDSS2 0.74 7.23 0.41 5.31e-12 Body mass index; CESC cis rs11252926 0.565 rs60553947 chr10:474284 T/C cg16386425 chr10:429943 DIP2C 0.48 5.99 0.35 6.99e-9 Psychosis in Alzheimer's disease; CESC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg05863683 chr7:1912471 MAD1L1 0.5 7.71 0.43 2.52e-13 Bipolar disorder and schizophrenia; CESC cis rs921968 0.565 rs6708192 chr2:219592227 A/G cg02176678 chr2:219576539 TTLL4 -0.42 -7.45 -0.42 1.32e-12 Mean corpuscular hemoglobin concentration; CESC cis rs6439153 0.933 rs6769662 chr3:128721310 A/C cg24203234 chr3:128598194 ACAD9 0.4 5.29 0.31 2.56e-7 Pneumococcal bacteremia; CESC cis rs7520050 0.966 rs946529 chr1:46485548 G/T cg24296786 chr1:45957014 TESK2 0.44 5.5 0.32 8.98e-8 Red blood cell count;Reticulocyte count; CESC cis rs684232 0.644 rs870183 chr17:599811 A/G cg15660573 chr17:549704 VPS53 -0.62 -8.57 -0.47 8.81e-16 Prostate cancer; CESC cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.95e-9 Extrinsic epigenetic age acceleration; CESC cis rs7249921 0.833 rs73044054 chr19:35666661 C/A cg15419183 chr19:35660584 FXYD5 0.55 8.48 0.46 1.57e-15 Platelet count; CESC cis rs4481887 0.604 rs4642918 chr1:248411057 A/C cg02052265 chr1:247712110 C1orf150 -0.31 -5.12 -0.3 5.88e-7 Common traits (Other); CESC cis rs1568889 1.000 rs12797712 chr11:28290890 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 9.75 0.51 2.09e-19 Bipolar disorder; CESC cis rs67311347 1.000 rs56303661 chr3:40520778 C/G cg24209194 chr3:40518798 ZNF619 0.5 6.13 0.35 3.09e-9 Renal cell carcinoma; CESC cis rs2952156 1.000 rs2643195 chr17:37853118 A/G cg20243544 chr17:37824526 PNMT 0.55 6.71 0.38 1.15e-10 Asthma; CESC cis rs7178572 1.000 rs12910361 chr15:77782335 A/G cg22256960 chr15:77711686 NA -0.6 -8.09 -0.44 2.19e-14 Type 2 diabetes; CESC cis rs6540556 0.517 rs11807619 chr1:209881373 G/T cg05527609 chr1:210001259 C1orf107 -0.59 -5.91 -0.34 1.05e-8 Red blood cell count; CESC cis rs57506017 0.606 rs2302634 chr7:12270770 T/A cg23422036 chr7:12250390 TMEM106B 0.39 5.17 0.3 4.57e-7 Neuroticism; CESC cis rs9287719 1.000 rs9679122 chr2:10751710 T/C cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs3126085 0.935 rs1496049 chr1:152161949 C/T cg03465714 chr1:152285911 FLG 0.48 5.73 0.33 2.68e-8 Atopic dermatitis; CESC cis rs910316 0.836 rs6574212 chr14:75671659 G/A cg11812906 chr14:75593930 NEK9 -0.81 -12.5 -0.61 1.66e-28 Height; CESC cis rs1707322 1.000 rs34446427 chr1:46417655 A/C cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs708547 0.647 rs2293175 chr4:57861358 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.5 -6.7 -0.38 1.21e-10 Response to bleomycin (chromatid breaks); CESC cis rs727505 1.000 rs10265763 chr7:124451514 G/A cg23710748 chr7:124431027 NA -0.44 -6.97 -0.39 2.46e-11 Lewy body disease; CESC cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg20476274 chr7:133979776 SLC35B4 0.58 7.49 0.42 1.03e-12 Mean platelet volume; CESC cis rs2239547 0.657 rs12488303 chr3:52862003 G/A cg11645453 chr3:52864694 ITIH4 0.32 5.89 0.34 1.15e-8 Schizophrenia; CESC cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg03433033 chr1:76189801 ACADM 0.58 5.57 0.32 6.2e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6951245 0.572 rs73264010 chr7:1040477 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.65 -6.07 -0.35 4.33e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2302729 0.578 rs2302728 chr12:2774668 A/C cg19945202 chr12:2788847 CACNA1C 0.46 6.67 0.38 1.5e-10 Sleep quality; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18664336 chr17:57970265 TUBD1;RPS6KB1 0.48 6.82 0.39 6.16e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2249625 0.816 rs2496499 chr6:72884414 T/A cg18830697 chr6:72922368 RIMS1 -0.39 -5.5 -0.32 8.88e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs1062177 1.000 rs2964612 chr5:151198750 G/A cg00977110 chr5:151150581 G3BP1 0.62 6.59 0.38 2.37e-10 Preschool internalizing problems; CESC cis rs3733585 0.534 rs7375642 chr4:9955236 A/G cg02734326 chr4:10020555 SLC2A9 -0.4 -5.77 -0.33 2.19e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs34734847 1.000 rs35360964 chr12:121156290 T/C cg21892295 chr12:121157589 UNC119B -0.42 -6.65 -0.38 1.66e-10 Mean corpuscular volume; CESC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg09359103 chr1:154839909 KCNN3 -0.68 -13.25 -0.63 4.21e-31 Prostate cancer; CESC cis rs208520 1.000 rs9453671 chr6:66991208 A/G cg07460842 chr6:66804631 NA 0.78 8.94 0.48 6.96e-17 Exhaled nitric oxide output; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08809979 chr16:69373666 COG8;NIP7 0.57 6.03 0.35 5.37e-9 Gut microbiome composition (summer); CESC cis rs2952156 0.920 rs907090 chr17:37833632 T/C cg20243544 chr17:37824526 PNMT 0.63 8.32 0.45 4.82e-15 Asthma; CESC cis rs1030877 0.960 rs3792050 chr2:105902255 T/C cg02079111 chr2:105885981 TGFBRAP1 -0.65 -10.1 -0.53 1.67e-20 Obesity-related traits; CESC cis rs10779751 1.000 rs2253213 chr1:11265785 A/G cg08854313 chr1:11322531 MTOR 0.77 9.78 0.52 1.72e-19 Body mass index; CESC cis rs4803468 1.000 rs878083 chr19:41897688 G/A cg09537434 chr19:41945824 ATP5SL -1.03 -18.58 -0.75 6.55e-50 Height; CESC trans rs35883536 0.935 rs1106347 chr1:101149059 A/T cg16931499 chr17:42786676 DBF4B 0.42 6.24 0.36 1.7e-9 Monocyte count; CESC cis rs60154123 0.730 rs587203 chr1:210463786 C/T cg21951975 chr1:209979733 IRF6 0.4 5.52 0.32 8.13e-8 Coronary artery disease; CESC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3820928 0.839 rs4675123 chr2:227800205 T/C cg05526886 chr2:227700861 RHBDD1 -0.39 -5.07 -0.3 7.46e-7 Pulmonary function; CESC cis rs2455799 0.552 rs1472697 chr3:15750268 G/A cg16303742 chr3:15540471 COLQ -0.4 -6.11 -0.35 3.45e-9 Mean platelet volume; CESC cis rs722599 0.748 rs2537824 chr14:75367349 T/C cg11812906 chr14:75593930 NEK9 -0.47 -5.63 -0.33 4.59e-8 IgG glycosylation; CESC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg15145296 chr3:125709740 NA -0.56 -5.91 -0.34 1.06e-8 Blood pressure (smoking interaction); CESC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg21747405 chr11:67723411 NA -0.44 -6.69 -0.38 1.3100000000000001e-10 Blood pressure (smoking interaction); CESC trans rs116095464 0.558 rs9312977 chr5:221916 G/C cg00938859 chr5:1591904 SDHAP3 0.6 6.66 0.38 1.55e-10 Breast cancer; CESC cis rs796364 1.000 rs281794 chr2:200846666 C/T cg23649088 chr2:200775458 C2orf69 0.55 5.16 0.3 4.74e-7 Schizophrenia; CESC cis rs35417517 1 rs35417517 chr7:91772730 CG/C cg17063962 chr7:91808500 NA 0.59 8.22 0.45 8.94e-15 Breast cancer; CESC cis rs559928 0.593 rs112275221 chr11:63936994 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.44 0.32 1.2e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs8051149 0.688 rs12444533 chr16:87869711 C/T cg01829163 chr16:87871160 SLC7A5 -0.56 -6.97 -0.39 2.55e-11 Blood metabolite levels; CESC cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.4 0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC trans rs2018683 0.621 rs10261556 chr7:28976636 G/T cg19402173 chr7:128379420 CALU -0.56 -7.37 -0.41 2.19e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs7647973 0.626 rs9824435 chr3:49674343 A/G cg07636037 chr3:49044803 WDR6 -0.55 -6.08 -0.35 4.26e-9 Menarche (age at onset); CESC cis rs854765 0.663 rs1052299 chr17:17750419 A/G cg16928487 chr17:17741425 SREBF1 0.58 10.26 0.53 5.21e-21 Total body bone mineral density; CESC cis rs35306767 0.903 rs765867 chr10:869901 G/T cg25019033 chr10:957182 NA -0.58 -6.13 -0.35 3.11e-9 Eosinophil percentage of granulocytes; CESC cis rs894734 0.535 rs2366143 chr12:54323256 G/A cg17410650 chr12:54324560 NA -0.5 -9.21 -0.49 1.06e-17 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10092158 chr1:151584907 SNX27 0.66 8.04 0.44 2.92e-14 Gut microbiome composition (summer); CESC trans rs1557351 0.723 rs2027702 chr18:54725272 A/G cg11433624 chr6:7146702 RREB1 -0.36 -6.0 -0.35 6.52e-9 Multiple sclerosis (age of onset); CESC cis rs6733011 0.508 rs12712041 chr2:99522059 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.11 -0.3 6.13e-7 Bipolar disorder; CESC cis rs1865760 0.566 rs1539183 chr6:26075051 G/C cg16482183 chr6:26056742 HIST1H1C 0.39 5.31 0.31 2.35e-7 Height; CESC cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9815354 1.000 rs6783001 chr3:41862232 C/A cg03022575 chr3:42003672 ULK4 0.45 5.15 0.3 5.19e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9899728 0.539 rs35928207 chr17:73033629 T/G cg27626185 chr17:73056755 KCTD2 -1.06 -9.13 -0.49 1.84e-17 Alzheimer's disease or small vessel stroke; CESC cis rs2228479 0.850 rs74251568 chr16:89903416 A/C cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs7086627 0.515 rs7907969 chr10:82153005 T/A cg00277334 chr10:82204260 NA -0.5 -7.37 -0.41 2.23e-12 Post bronchodilator FEV1; CESC cis rs7998202 0.667 rs282578 chr13:113358584 A/G cg02820901 chr13:113351484 ATP11A 0.62 5.83 0.34 1.58e-8 Glycated hemoglobin levels; CESC cis rs6460942 1.000 rs112794590 chr7:12319426 G/A cg06484146 chr7:12443880 VWDE -0.81 -8.78 -0.47 2.13e-16 Coronary artery disease; CESC cis rs1005277 0.683 rs7923868 chr10:37989766 T/C cg00409905 chr10:38381863 ZNF37A -0.48 -6.43 -0.37 5.87e-10 Extrinsic epigenetic age acceleration; CESC cis rs2732480 0.500 rs2932093 chr12:48648271 G/T cg24011408 chr12:48396354 COL2A1 0.44 6.18 0.35 2.41e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs644148 0.872 rs2686780 chr19:44974126 G/C cg15540054 chr19:45004280 ZNF180 -0.6 -6.48 -0.37 4.45e-10 Personality dimensions; CESC trans rs11098499 1.000 rs13435802 chr4:120177960 A/T cg25214090 chr10:38739885 LOC399744 -0.64 -8.68 -0.47 4.09e-16 Corneal astigmatism; CESC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.41e-28 Prudent dietary pattern; CESC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.26 0.41 4.24e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs372883 0.600 rs2832298 chr21:30743863 C/G cg24692254 chr21:30365293 RNF160 0.53 6.7 0.38 1.22e-10 Pancreatic cancer; CESC cis rs2463822 0.688 rs7121684 chr11:62162389 T/C cg06239285 chr11:62104954 ASRGL1 -1.07 -9.18 -0.49 1.23e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9583531 0.509 rs12184676 chr13:111396484 A/G cg24331049 chr13:111365604 ING1 -0.78 -7.72 -0.43 2.43e-13 Coronary artery disease; CESC cis rs926938 0.527 rs360666 chr1:115481290 C/T cg12756093 chr1:115239321 AMPD1 0.46 6.37 0.36 8.39e-10 Autism; CESC cis rs668210 0.793 rs1204011 chr11:65741086 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.63 -5.89 -0.34 1.19e-8 Cerebrospinal fluid biomarker levels; CESC cis rs11760633 0.672 rs11763500 chr7:1826385 T/A cg23422044 chr7:1970798 MAD1L1 -0.43 -5.17 -0.3 4.54e-7 Coronary artery disease; CESC cis rs2985684 1.000 rs11157696 chr14:50105746 C/G cg10008539 chr14:50087325 RPL36AL;MGAT2 0.44 5.13 0.3 5.62e-7 Carotid intima media thickness; CESC cis rs4332037 0.539 rs34809719 chr7:2028968 G/T cg23422044 chr7:1970798 MAD1L1 -0.5 -5.35 -0.31 1.9e-7 Bipolar disorder; CESC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.92 14.12 0.66 3.86e-34 Prudent dietary pattern; CESC trans rs7672847 0.547 rs4379028 chr4:170450913 C/A cg19308436 chr1:237949471 RYR2 0.64 6.72 0.38 1.08e-10 Subjective well-being; CESC cis rs2742417 1.000 rs2742447 chr3:45763977 C/T cg10512202 chr3:45649293 LIMD1 0.36 5.21 0.3 3.78e-7 Response to anti-depressant treatment in major depressive disorder; CESC cis rs7914558 1.000 rs10786740 chr10:104935593 G/C cg04362960 chr10:104952993 NT5C2 0.46 6.17 0.35 2.6e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1799949 0.965 rs4793237 chr17:41436595 A/T cg25072359 chr17:41440525 NA 0.49 7.24 0.41 4.92e-12 Menopause (age at onset); CESC cis rs9325144 0.624 rs10783330 chr12:39114084 A/G cg26384229 chr12:38710491 ALG10B -0.53 -7.43 -0.42 1.52e-12 Morning vs. evening chronotype; CESC cis rs6866344 0.570 rs1132338 chr5:178139442 T/G cg03877680 chr5:178157825 ZNF354A 0.81 9.91 0.52 6.58e-20 Neutrophil percentage of white cells; CESC trans rs1814175 0.791 rs1722023 chr11:49908136 G/C cg15704280 chr7:45808275 SEPT13 -1.03 -21.21 -0.79 4.77e-59 Height; CESC cis rs4523957 0.552 rs2760742 chr17:2019037 A/G cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs208520 1.000 rs208537 chr6:66963544 A/G cg07460842 chr6:66804631 NA -0.9 -10.34 -0.54 2.79e-21 Exhaled nitric oxide output; CESC cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg03433033 chr1:76189801 ACADM 0.64 7.52 0.42 8.69e-13 Blood metabolite levels;Acylcarnitine levels; CESC trans rs7615952 0.800 rs2062773 chr3:125639648 T/C cg07211511 chr3:129823064 LOC729375 -1.13 -16.52 -0.71 1.28e-42 Blood pressure (smoking interaction); CESC trans rs3942852 0.712 rs10742828 chr11:48104555 A/G cg15704280 chr7:45808275 SEPT13 -0.72 -8.62 -0.47 6.39e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs6598955 0.572 rs6598951 chr1:26592714 G/T cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.05 0.3 8.16e-7 Obesity-related traits; CESC cis rs9291683 0.655 rs55941493 chr4:10100341 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -8.73 -0.47 2.86e-16 Bone mineral density; CESC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg02569458 chr12:86230093 RASSF9 0.57 8.34 0.46 4.13e-15 Major depressive disorder; CESC cis rs11674184 0.714 rs16857668 chr2:11723110 G/A cg07314298 chr2:11723111 GREB1 -0.66 -10.21 -0.53 7.63e-21 Endometriosis; CESC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg02869306 chr7:64672164 INTS4L1 -0.32 -5.2 -0.3 4.04e-7 Calcium levels; CESC cis rs7246865 0.724 rs10424674 chr19:17183185 G/A cg19418318 chr19:17219073 MYO9B 0.33 5.34 0.31 2.04e-7 Reticulocyte fraction of red cells; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg25934064 chr3:52569026 NT5DC2 0.26 5.27 0.31 2.83e-7 Electroencephalogram traits; CESC cis rs4481887 1.000 rs4589143 chr1:248470446 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.65 0.38 1.71e-10 Common traits (Other); CESC cis rs2072499 0.767 rs3001789 chr1:156197614 T/G cg24450063 chr1:156163899 SLC25A44 0.83 12.72 0.62 2.9e-29 Testicular germ cell tumor; CESC cis rs1008375 1.000 rs6849704 chr4:17652031 G/C cg15017067 chr4:17643749 FAM184B 0.35 5.07 0.3 7.59e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs791888 0.965 rs791873 chr10:89405558 C/T cg13926569 chr10:89418898 PAPSS2 -0.39 -5.41 -0.32 1.38e-7 Magnesium levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15331837 chr8:142232772 SLC45A4 0.54 7.49 0.42 1.06e-12 Fibrinogen levels; CESC cis rs17253792 0.822 rs8007065 chr14:56081272 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs11112613 0.713 rs4015312 chr12:105948757 A/G cg03607813 chr12:105948248 NA 0.62 7.04 0.4 1.64e-11 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs2559856 1.000 rs10860771 chr12:102087242 A/G cg15068132 chr12:102092402 CHPT1 -0.39 -5.18 -0.3 4.38e-7 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04703227 chr1:19923504 C1orf151 0.57 6.18 0.35 2.42e-9 Gut microbiome composition (summer); CESC cis rs1788820 0.917 rs1788762 chr18:21132571 G/C cg14672496 chr18:21087552 C18orf8 0.56 7.57 0.42 6.08e-13 Body mass index; CESC cis rs2243480 1.000 rs1618893 chr7:66096119 C/T cg13147721 chr7:65941812 NA -0.59 -6.02 -0.35 5.87e-9 Diabetic kidney disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg06387028 chr7:72395397 POM121 -0.48 -6.07 -0.35 4.34e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg22875332 chr1:76189707 ACADM 0.58 5.66 0.33 3.97e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs698813 0.604 rs2340813 chr2:44487398 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 5.8 0.34 1.93e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg21918786 chr6:109611834 NA -0.38 -5.82 -0.34 1.67e-8 Reticulocyte fraction of red cells; CESC cis rs12410462 1.000 rs16847833 chr1:227626662 G/A cg23173402 chr1:227635558 NA 0.57 5.92 0.34 9.9e-9 Major depressive disorder; CESC cis rs2573652 0.722 rs11858932 chr15:100542763 G/A cg00587665 chr15:100533223 ADAMTS17 -0.4 -6.41 -0.37 6.5e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10054262 chr7:856283 UNC84A 0.61 7.08 0.4 1.32e-11 Gut microbiome composition (summer); CESC trans rs61931739 0.500 rs11053166 chr12:34385898 A/C cg26384229 chr12:38710491 ALG10B -0.76 -10.69 -0.55 2.14e-22 Morning vs. evening chronotype; CESC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg05313129 chr8:58192883 C8orf71 -0.57 -6.61 -0.38 2.05e-10 Developmental language disorder (linguistic errors); CESC cis rs950169 1.000 rs11638297 chr15:84782417 A/C cg03959625 chr15:84868606 LOC388152 0.36 5.13 0.3 5.64e-7 Schizophrenia; CESC trans rs829883 1.000 rs249837 chr12:98876535 A/G cg04550079 chr16:67212681 KIAA0895L -0.37 -6.07 -0.35 4.34e-9 Colorectal adenoma (advanced); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07364676 chr22:29137974 CHEK2;HSCB 0.58 7.01 0.4 1.97e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24035104 chr1:44445524 B4GALT2 0.6 7.5 0.42 9.81e-13 Gut microbiome composition (summer); CESC cis rs9303401 0.527 rs12946522 chr17:56768103 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.97 11.3 0.57 2.06e-24 Cognitive test performance; CESC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg18446336 chr7:2847575 GNA12 -0.36 -5.3 -0.31 2.49e-7 Height; CESC cis rs7927592 0.956 rs11228258 chr11:68254328 A/C cg16797656 chr11:68205561 LRP5 -0.38 -5.45 -0.32 1.18e-7 Total body bone mineral density; CESC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg06481639 chr22:41940642 POLR3H -0.68 -7.3 -0.41 3.37e-12 Vitiligo; CESC cis rs1707322 1.000 rs4460583 chr1:46449918 C/G cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg26335602 chr6:28129616 ZNF389 0.46 6.24 0.36 1.75e-9 Depression; CESC cis rs71403859 0.730 rs17356206 chr16:71736359 G/C cg08717414 chr16:71523259 ZNF19 -0.69 -5.79 -0.33 2.02e-8 Post bronchodilator FEV1; CESC cis rs897080 0.552 rs1067375 chr2:44650118 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.47 -5.77 -0.33 2.24e-8 Height; CESC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg23803603 chr1:2058230 PRKCZ -0.38 -6.7 -0.38 1.23e-10 Height; CESC cis rs72781680 0.611 rs72781699 chr2:24277709 G/A cg08917208 chr2:24149416 ATAD2B 0.61 5.95 0.34 8.56e-9 Lymphocyte counts; CESC cis rs11122272 0.735 rs2437150 chr1:231488524 A/G cg06096015 chr1:231504339 EGLN1 -0.38 -5.69 -0.33 3.37e-8 Hemoglobin concentration; CESC cis rs7714584 1.000 rs59531858 chr5:150247063 T/G cg22134413 chr5:150180641 NA 0.61 5.92 0.34 9.83e-9 Crohn's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01745522 chr6:26217416 HIST1H2BG;HIST1H2AE -0.51 -6.68 -0.38 1.4e-10 Ulcerative colitis; CESC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg00684032 chr4:1343700 KIAA1530 0.41 5.72 0.33 2.95e-8 Obesity-related traits; CESC cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 7.6 0.42 5.28e-13 Personality dimensions; CESC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg15445000 chr17:37608096 MED1 -0.38 -6.32 -0.36 1.13e-9 Glomerular filtration rate (creatinine); CESC cis rs17750015 0.733 rs12454362 chr18:54396186 G/A cg18434998 chr18:54306185 TXNL1 -0.44 -5.65 -0.33 4.12e-8 Depression and alcohol dependence; CESC cis rs6503525 0.701 rs28618095 chr17:38109075 T/C cg17467752 chr17:38218738 THRA 0.41 5.04 0.3 8.56e-7 Asthma; CESC cis rs7202877 0.706 rs8046184 chr16:75411725 T/C cg04384234 chr16:75411784 CFDP1 -0.49 -5.89 -0.34 1.16e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs4727027 0.727 rs3801980 chr7:148878620 T/A cg23583168 chr7:148888333 NA -0.76 -10.27 -0.53 4.85e-21 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs11792861 0.926 rs11788825 chr9:111829757 T/G cg05043794 chr9:111880884 C9orf5 -0.37 -6.38 -0.36 7.79e-10 Menarche (age at onset); CESC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg25036284 chr2:26402008 FAM59B -0.9 -10.49 -0.54 8.96e-22 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.08 0.3 7.26e-7 Menopause (age at onset); CESC trans rs1814175 0.645 rs10839382 chr11:49823172 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -17.86 -0.74 2.18e-47 Height; CESC cis rs1797081 0.901 rs703059 chr10:16876402 G/A cg23933602 chr10:16859644 RSU1 1.12 23.87 0.83 5.36e-68 Platelet distribution width; CESC cis rs34779708 0.733 rs7083266 chr10:35541632 C/A cg04310649 chr10:35416472 CREM -0.47 -5.39 -0.31 1.59e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg22764044 chr5:178986830 RUFY1 0.41 5.78 0.33 2.04e-8 Lung cancer; CESC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg18301423 chr5:131593218 PDLIM4 -0.41 -5.92 -0.34 9.8e-9 Acylcarnitine levels; CESC cis rs2404602 0.692 rs58973160 chr15:77000342 T/C cg22467129 chr15:76604101 ETFA -0.35 -5.12 -0.3 6e-7 Blood metabolite levels; CESC cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 10.88 0.56 5.02e-23 Hip circumference adjusted for BMI; CESC cis rs80282103 0.867 rs13377037 chr10:1068639 C/T cg08668510 chr10:1095578 IDI1 0.68 5.56 0.32 6.57e-8 Glomerular filtration rate (creatinine); CESC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg00149659 chr3:10157352 C3orf10 0.75 9.05 0.49 3.07e-17 Alzheimer's disease; CESC cis rs4243830 0.850 rs11122043 chr1:6580429 C/T cg05709478 chr1:6581295 PLEKHG5 -0.44 -5.06 -0.3 8.02e-7 Body mass index; CESC cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg22467129 chr15:76604101 ETFA -0.38 -5.81 -0.34 1.81e-8 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25586305 chr2:234281690 DGKD -0.61 -6.73 -0.38 1.02e-10 Gut microbiome composition (summer); CESC cis rs12681288 0.676 rs4565481 chr8:1001944 C/T cg04851639 chr8:1020857 NA -0.33 -6.93 -0.39 3.23e-11 Schizophrenia; CESC cis rs7772486 0.875 rs2748483 chr6:146335560 A/T cg23711669 chr6:146136114 FBXO30 -0.84 -11.66 -0.58 1.21e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs45535039 1.000 rs7121752 chr11:119140173 C/T cg16724696 chr11:118992527 HINFP 0.44 5.32 0.31 2.2e-7 Plateletcrit; CESC cis rs2456568 0.802 rs1574515 chr11:93629643 T/C cg26875233 chr11:93583750 C11orf90 -0.3 -5.35 -0.31 1.92e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs3096299 0.933 rs2965939 chr16:89493043 G/A cg02187348 chr16:89574699 SPG7 0.59 7.99 0.44 4.03e-14 Multiple myeloma (IgH translocation); CESC cis rs2481665 0.608 rs2457815 chr1:62596679 C/T cg18591186 chr1:62594603 INADL -0.72 -10.23 -0.53 6.22e-21 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg18402987 chr7:1209562 NA 0.73 7.25 0.41 4.54e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs300703 0.542 rs415660 chr2:189972 C/T cg21211680 chr2:198530 NA 0.89 10.11 0.53 1.56e-20 Blood protein levels; CESC cis rs12188164 0.543 rs7728027 chr5:459943 T/C cg16584290 chr5:462447 EXOC3 0.47 7.09 0.4 1.19e-11 Cystic fibrosis severity; CESC cis rs2046867 0.862 rs6766747 chr3:72856551 T/C cg25664220 chr3:72788482 NA -0.48 -7.03 -0.4 1.73e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6540556 0.723 rs11487867 chr1:209892070 G/T cg05527609 chr1:210001259 C1orf107 -0.78 -7.84 -0.43 1.13e-13 Red blood cell count; CESC trans rs9650657 0.589 rs6985109 chr8:10761585 A/G cg06636001 chr8:8085503 FLJ10661 0.51 6.28 0.36 1.4e-9 Neuroticism; CESC cis rs9611565 0.608 rs202652 chr22:41838792 A/G cg17376030 chr22:41985996 PMM1 -0.56 -6.22 -0.36 1.92e-9 Vitiligo; CESC cis rs2070488 1.000 rs2268753 chr3:38500189 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.95 17.87 0.74 2.14e-47 Electrocardiographic conduction measures; CESC cis rs4568518 0.616 rs4721675 chr7:18004702 T/C cg03009463 chr7:17980271 SNX13 0.41 5.49 0.32 9.25e-8 Measles; CESC cis rs12477438 0.520 rs6717729 chr2:99756941 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.7 0.69 1.05e-39 Chronic sinus infection; CESC cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg22307297 chr20:60903441 LAMA5 -0.38 -5.33 -0.31 2.1e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs4664304 0.739 rs66814375 chr2:160716059 C/T cg03641300 chr2:160917029 PLA2R1 -0.39 -5.1 -0.3 6.45e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs959260 1.000 rs8081927 chr17:73379085 C/T cg20590849 chr17:73267439 MIF4GD -0.59 -6.78 -0.38 7.58e-11 Systemic lupus erythematosus; CESC cis rs13256369 0.802 rs13256404 chr8:8562974 T/C cg18904891 chr8:8559673 CLDN23 0.73 8.12 0.45 1.74e-14 Obesity-related traits; CESC cis rs752010 0.714 rs2148635 chr1:42082452 C/T cg12614395 chr1:42085415 HIVEP3 -0.3 -5.32 -0.31 2.21e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs7520050 0.966 rs6668284 chr1:46354510 G/A cg03146154 chr1:46216737 IPP -0.48 -6.22 -0.36 1.94e-9 Red blood cell count;Reticulocyte count; CESC cis rs2180341 0.920 rs9401951 chr6:127671632 A/C cg27446573 chr6:127587934 RNF146 1.07 15.44 0.69 8.48e-39 Breast cancer; CESC cis rs11098499 0.865 rs2389809 chr4:120377399 T/C cg24375607 chr4:120327624 NA 0.44 5.51 0.32 8.65e-8 Corneal astigmatism; CESC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg18876405 chr7:65276391 NA 0.7 9.67 0.51 3.76e-19 Calcium levels; CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg27094323 chr7:1216898 NA -0.43 -6.03 -0.35 5.61e-9 Longevity;Endometriosis; CESC cis rs68170813 0.559 rs77185844 chr7:106812916 A/C cg02696742 chr7:106810147 HBP1 -0.54 -5.13 -0.3 5.7e-7 Coronary artery disease; CESC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg06074448 chr4:187884817 NA -0.38 -5.35 -0.31 1.91e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs9309473 0.718 rs10175529 chr2:73606093 A/G cg20560298 chr2:73613845 ALMS1 -0.51 -7.1 -0.4 1.18e-11 Metabolite levels; CESC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.74 7.36 0.41 2.29e-12 Platelet count; CESC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg22800045 chr5:56110881 MAP3K1 0.44 5.35 0.31 1.9e-7 Coronary artery disease; CESC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg07507251 chr3:52567010 NT5DC2 0.32 5.5 0.32 8.74e-8 Bipolar disorder; CESC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 9.97 0.52 4.3e-20 Prudent dietary pattern; CESC cis rs7605827 0.930 rs10201564 chr2:15623608 C/G cg19274914 chr2:15703543 NA 0.36 6.46 0.37 5.1e-10 Educational attainment (years of education); CESC cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg25517755 chr10:38738941 LOC399744 -0.49 -6.36 -0.36 8.84e-10 Extrinsic epigenetic age acceleration; CESC cis rs1348850 0.526 rs2141157 chr2:178374112 C/T cg22681709 chr2:178499509 PDE11A -0.5 -5.26 -0.31 2.97e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs12477438 0.765 rs1115757 chr2:99660146 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs7267979 1.000 rs397119 chr20:25440187 C/A cg08601574 chr20:25228251 PYGB 0.37 5.28 0.31 2.73e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24865495 chr11:63912769 MACROD1 0.47 6.04 0.35 5.3e-9 Fibrinogen levels; CESC trans rs7615952 0.599 rs6779141 chr3:125709995 A/T cg07211511 chr3:129823064 LOC729375 -0.56 -6.39 -0.37 7.25e-10 Blood pressure (smoking interaction); CESC cis rs9911578 1.000 rs4372750 chr17:57013803 A/C cg12560992 chr17:57184187 TRIM37 -0.92 -15.13 -0.68 1.08e-37 Intelligence (multi-trait analysis); CESC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg27266027 chr21:40555129 PSMG1 0.45 5.48 0.32 1.01e-7 Cognitive function; CESC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg09365446 chr1:150670422 GOLPH3L -0.4 -5.59 -0.33 5.51e-8 Tonsillectomy; CESC cis rs854765 0.616 rs8076747 chr17:17853595 C/T cg09796270 chr17:17721594 SREBF1 0.41 5.57 0.32 6.41e-8 Total body bone mineral density; CESC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg08736216 chr1:53307985 ZYG11A -0.38 -6.26 -0.36 1.52e-9 Monocyte count; CESC cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg03433033 chr1:76189801 ACADM 0.7 9.43 0.5 2.18e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs896854 0.517 rs9643353 chr8:95957063 A/G cg23172400 chr8:95962367 TP53INP1 0.44 8.27 0.45 6.65e-15 Type 2 diabetes; CESC cis rs4819052 0.959 rs9976074 chr21:46655638 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 10.85 0.55 5.96e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3785574 0.962 rs114027117 chr17:61939935 T/A cg07677032 chr17:61819896 STRADA 0.43 5.68 0.33 3.62e-8 Height; CESC cis rs7582720 0.943 rs114372659 chr2:203715514 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7714584 1.000 rs1428555 chr5:150257391 A/G cg22134413 chr5:150180641 NA -0.52 -5.89 -0.34 1.17e-8 Crohn's disease; CESC cis rs2370759 1.000 rs77165999 chr10:32577131 T/C cg18270830 chr10:32634957 EPC1 0.73 7.22 0.41 5.35e-12 Sexual dysfunction (female); CESC cis rs7726839 0.540 rs72707016 chr5:665148 A/G cg09021430 chr5:549028 NA -0.42 -5.16 -0.3 4.75e-7 Obesity-related traits; CESC cis rs2228479 0.850 rs12597296 chr16:89822331 C/T cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs7553864 0.667 rs7512650 chr1:87609076 T/C cg17420885 chr1:87600446 LOC339524 -0.46 -6.28 -0.36 1.36e-9 Smoking behavior; CESC cis rs2279817 0.775 rs35493100 chr1:17993120 C/T cg21791023 chr1:18019539 ARHGEF10L -0.66 -8.15 -0.45 1.42e-14 Neuroticism; CESC cis rs854765 0.583 rs9912895 chr17:17826020 C/T cg09796270 chr17:17721594 SREBF1 -0.43 -6.12 -0.35 3.4e-9 Total body bone mineral density; CESC cis rs17253792 0.545 rs35418987 chr14:56017407 T/G cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg22920501 chr2:26401640 FAM59B -0.64 -7.75 -0.43 2.03e-13 Gut microbiome composition (summer); CESC cis rs6732160 0.574 rs12465780 chr2:73472012 A/G cg01422370 chr2:73384389 NA -0.44 -7.61 -0.42 4.75e-13 Intelligence (multi-trait analysis); CESC cis rs7267979 1.000 rs398036 chr20:25439850 C/T cg08601574 chr20:25228251 PYGB 0.37 5.28 0.31 2.73e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7809950 1.000 rs67982599 chr7:107100104 T/G cg23024343 chr7:107201750 COG5 -0.4 -5.65 -0.33 4.11e-8 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26294578 chr17:79319535 NA -0.42 -6.07 -0.35 4.47e-9 Gambling; CESC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg05564831 chr3:52568323 NT5DC2 0.45 6.97 0.39 2.55e-11 Bipolar disorder; CESC cis rs6690583 0.697 rs2012369 chr1:85520845 T/C cg11262906 chr1:85462892 MCOLN2 -0.43 -5.16 -0.3 4.86e-7 Serum sulfate level; CESC cis rs909674 0.690 rs1972280 chr22:39831986 T/A cg01416388 chr22:39784598 NA -0.58 -7.43 -0.42 1.5e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs870825 0.860 rs72703525 chr4:185605154 T/C cg04058563 chr4:185651563 MLF1IP 0.54 5.24 0.31 3.27e-7 Blood protein levels; CESC cis rs7605827 0.930 rs2380652 chr2:15594926 T/C cg19274914 chr2:15703543 NA 0.33 5.97 0.34 7.72e-9 Educational attainment (years of education); CESC cis rs9611519 0.780 rs1535048 chr22:41684093 C/T cg06481639 chr22:41940642 POLR3H -0.48 -5.28 -0.31 2.76e-7 Neuroticism; CESC cis rs868036 0.609 rs2127163 chr15:68090842 C/T cg24579218 chr15:68104479 NA -0.37 -5.13 -0.3 5.6e-7 Restless legs syndrome; CESC cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg20503657 chr10:835505 NA 0.82 8.27 0.45 6.52e-15 Eosinophil percentage of granulocytes; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg03143742 chr22:20792143 SCARF2 -0.4 -6.25 -0.36 1.6e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.72 6.44 0.37 5.73e-10 Platelet count; CESC cis rs7945705 0.520 rs1984791 chr11:9035027 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.45 6.92 0.39 3.33e-11 Hemoglobin concentration; CESC cis rs3857067 0.967 rs1841925 chr4:95035175 A/G cg11021082 chr4:95130006 SMARCAD1 -0.51 -7.78 -0.43 1.65e-13 QT interval; CESC cis rs796364 1.000 rs166845 chr2:200823360 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 8.43 0.46 2.18e-15 Schizophrenia; CESC cis rs1670533 0.932 rs10902753 chr4:1056223 G/A cg27284194 chr4:1044797 NA 0.47 5.99 0.35 6.72e-9 Recombination rate (females); CESC cis rs2243480 0.803 rs13224048 chr7:65993766 G/A cg13147721 chr7:65941812 NA -0.95 -8.91 -0.48 8.34e-17 Diabetic kidney disease; CESC cis rs6142102 0.625 rs2050208 chr20:32543573 A/G cg08999081 chr20:33150536 PIGU 0.34 5.12 0.3 5.93e-7 Skin pigmentation; CESC cis rs4660261 0.526 rs2485996 chr1:44354661 C/T cg13606994 chr1:44402422 ARTN -0.38 -5.81 -0.34 1.81e-8 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19828298 chr1:3713105 LRRC47 -0.4 -6.12 -0.35 3.43e-9 Gambling; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02262025 chr16:75657287 ADAT1 -0.45 -6.36 -0.36 8.67e-10 Fibrinogen levels; CESC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg24209194 chr3:40518798 ZNF619 0.51 6.49 0.37 4.29e-10 Renal cell carcinoma; CESC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg07701084 chr6:150067640 NUP43 0.46 6.47 0.37 4.62e-10 Lung cancer; CESC cis rs2549003 1.000 rs7735073 chr5:131815357 G/A cg21138405 chr5:131827807 IRF1 0.54 9.38 0.5 3.2e-18 Asthma (sex interaction); CESC cis rs3768617 0.740 rs28533496 chr1:183019885 G/T ch.1.3577855R chr1:183094577 LAMC1 0.65 8.84 0.48 1.33e-16 Fuchs's corneal dystrophy; CESC cis rs854765 0.547 rs8069811 chr17:17922280 G/A cg09796270 chr17:17721594 SREBF1 0.38 5.26 0.31 2.92e-7 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22864355 chr14:105225861 SIVA1 0.42 6.1 0.35 3.8e-9 Fibrinogen levels; CESC cis rs10267417 0.544 rs2072185 chr7:19748700 G/A cg05791153 chr7:19748676 TWISTNB 0.94 10.71 0.55 1.81e-22 Night sleep phenotypes; CESC cis rs4077515 0.874 rs10781505 chr9:139271355 C/T cg14169450 chr9:139327907 INPP5E -0.4 -5.78 -0.33 2.07e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg00815214 chr21:47717953 NA -0.34 -5.14 -0.3 5.37e-7 Testicular germ cell tumor; CESC cis rs55788414 0.932 rs2317122 chr16:81182819 A/G cg06400318 chr16:81190750 PKD1L2 -0.59 -6.97 -0.39 2.49e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg06212747 chr3:49208901 KLHDC8B 0.74 9.74 0.51 2.27e-19 Parkinson's disease; CESC cis rs2120019 1.000 rs12903201 chr15:75370776 A/C cg17294928 chr15:75287854 SCAMP5 -0.59 -6.65 -0.38 1.64e-10 Blood trace element (Zn levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19244826 chr22:19466934 UFD1L;CDC45L -0.71 -8.84 -0.48 1.39e-16 Gut microbiome composition (summer); CESC cis rs10207060 0.778 rs6543581 chr2:240702308 C/T cg20333904 chr2:240724165 NA 0.37 5.63 0.33 4.65e-8 Obesity-related traits; CESC trans rs9858542 1.000 rs11709525 chr3:49690496 C/T cg21659725 chr3:3221576 CRBN -0.54 -6.56 -0.37 2.84e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg24675658 chr1:53192096 ZYG11B -0.58 -7.37 -0.41 2.22e-12 Monocyte count; CESC cis rs35740288 0.571 rs11629608 chr15:86330124 C/G cg20737812 chr15:86336631 KLHL25 -0.42 -5.2 -0.3 3.96e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs728616 0.867 rs61860421 chr10:81743399 C/T cg05935833 chr10:81318306 SFTPA2 -0.52 -5.06 -0.3 7.72e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs11608355 0.532 rs7968387 chr12:109788019 A/C cg19025524 chr12:109796872 NA -0.47 -6.59 -0.38 2.32e-10 Neuroticism; CESC trans rs9858542 0.953 rs1801143 chr3:49570200 C/T cg21659725 chr3:3221576 CRBN -0.51 -6.06 -0.35 4.6e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07477109 chr7:99006266 BUD31;PDAP1 -0.49 -6.31 -0.36 1.2e-9 Ulcerative colitis; CESC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg19346786 chr7:2764209 NA -0.36 -5.17 -0.3 4.71e-7 Height; CESC cis rs9488822 0.597 rs12214881 chr6:116342187 G/T cg05304507 chr6:116381966 FRK 0.25 6.58 0.37 2.49e-10 Cholesterol, total;LDL cholesterol; CESC cis rs36051895 0.632 rs10974984 chr9:5150427 T/C cg02405213 chr9:5042618 JAK2 -0.54 -6.92 -0.39 3.39e-11 Pediatric autoimmune diseases; CESC cis rs4901869 0.932 rs12878445 chr14:59339361 A/G cg02291164 chr14:59296302 NA 0.45 7.81 0.43 1.3e-13 Panic disorder; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg12269905 chr21:38574668 TTC3 0.49 6.08 0.35 4.09e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs365132 0.875 rs3923879 chr5:176355312 C/T cg16309518 chr5:176445507 NA -0.37 -5.38 -0.31 1.6e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10158133 chr10:75488242 BMS1P4 -0.55 -6.4 -0.37 6.92e-10 Gut microbiome composition (summer); CESC cis rs9649465 0.967 rs3779261 chr7:123315174 A/G cg04330084 chr7:123175371 IQUB -0.39 -5.36 -0.31 1.82e-7 Migraine; CESC cis rs7560272 0.501 rs12713790 chr2:73945611 C/T cg20560298 chr2:73613845 ALMS1 0.41 5.69 0.33 3.43e-8 Schizophrenia; CESC cis rs11203032 0.634 rs3802658 chr10:90965691 C/T cg16672925 chr10:90967113 CH25H -0.65 -6.35 -0.36 9.25e-10 Heart failure; CESC cis rs752010 0.746 rs11210499 chr1:42089703 C/T cg06885757 chr1:42089581 HIVEP3 -0.54 -9.35 -0.5 3.81e-18 Lupus nephritis in systemic lupus erythematosus; CESC cis rs3768617 0.510 rs10911242 chr1:183072147 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 14.27 0.66 1.19e-34 Fuchs's corneal dystrophy; CESC cis rs6499129 0.867 rs7196853 chr16:67560613 T/C cg26727032 chr16:67993705 SLC12A4 -0.51 -5.4 -0.31 1.49e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1568889 0.592 rs7110074 chr11:28469325 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.55 5.49 0.32 9.37e-8 Bipolar disorder; CESC cis rs2439831 1.000 rs2467736 chr15:43784917 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.25 0.53 5.49e-21 Lung cancer in ever smokers; CESC cis rs6736093 0.901 rs11675946 chr2:112743033 C/T cg12686935 chr2:112915763 FBLN7 0.41 5.64 0.33 4.35e-8 Coronary artery disease; CESC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg19774624 chr17:42201019 HDAC5 -0.89 -13.91 -0.65 2.12e-33 Total body bone mineral density; CESC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg21535942 chr1:75199100 CRYZ;TYW3 -0.43 -5.63 -0.33 4.55e-8 Resistin levels; CESC cis rs4595586 0.525 rs2892450 chr12:39363678 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.42 7.28e-13 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23702897 chr4:2263850 MXD4 -0.54 -7.41 -0.41 1.71e-12 Fibrinogen levels; CESC cis rs7264396 0.635 rs6060703 chr20:34529906 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.1 -0.56 9.32e-24 Total cholesterol levels; CESC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg11644478 chr21:40555479 PSMG1 0.98 14.21 0.66 1.87e-34 Cognitive function; CESC cis rs6788895 1.000 rs79709238 chr3:150488477 A/C cg09723797 chr3:150481914 SIAH2 0.68 5.09 0.3 6.7e-7 Breast cancer; CESC cis rs12190007 0.547 rs1018559 chr6:169854176 A/G cg15038512 chr6:170123185 PHF10 -0.56 -8.01 -0.44 3.59e-14 Obesity-related traits; CESC cis rs9300255 0.739 rs1402275 chr12:123750895 A/G cg00376283 chr12:123451042 ABCB9 0.74 9.37 0.5 3.36e-18 Neutrophil percentage of white cells; CESC cis rs847577 0.630 rs13221758 chr7:97719806 A/C cg24562669 chr7:97807699 LMTK2 0.83 14.61 0.67 7.49e-36 Breast cancer; CESC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg25767906 chr1:53392781 SCP2 -0.56 -7.83 -0.43 1.18e-13 Monocyte count; CESC cis rs12130219 1.000 rs1552994 chr1:152171461 A/G cg17718321 chr1:152188247 HRNR 0.41 5.4 0.32 1.46e-7 Inflammatory skin disease; CESC cis rs3740713 1.000 rs78549183 chr11:18459715 A/G cg23797887 chr11:18477753 LDHAL6A -0.53 -5.27 -0.31 2.89e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg23158103 chr7:148848205 ZNF398 0.39 6.33 0.36 1.04e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22595711 chr4:83351836 ENOPH1;HNRPDL -0.43 -6.48 -0.37 4.56e-10 Gambling; CESC cis rs2228479 0.681 rs3212346 chr16:89982358 G/A cg06558623 chr16:89946397 TCF25 0.66 6.29 0.36 1.3e-9 Skin colour saturation; CESC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg18758796 chr5:131593413 PDLIM4 0.39 5.31 0.31 2.37e-7 Breast cancer; CESC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg00106254 chr7:1943704 MAD1L1 -0.51 -6.48 -0.37 4.52e-10 Bipolar disorder and schizophrenia; CESC cis rs977987 0.872 rs1542864 chr16:75471378 G/A cg03315344 chr16:75512273 CHST6 0.42 6.19 0.36 2.34e-9 Dupuytren's disease; CESC cis rs4950322 0.570 rs72691032 chr1:146732774 G/A cg16700924 chr1:146552102 NA -0.41 -5.12 -0.3 5.98e-7 Protein quantitative trait loci; CESC cis rs4971059 0.608 rs7366138 chr1:155088350 G/A cg22049894 chr1:155113146 DPM3 0.42 5.25 0.31 3.16e-7 Breast cancer; CESC cis rs2625529 0.652 rs2929532 chr15:72345110 C/T cg16672083 chr15:72433130 SENP8 0.46 7.08 0.4 1.26e-11 Red blood cell count; CESC cis rs7772486 0.686 rs7739735 chr6:146123536 G/A cg23711669 chr6:146136114 FBXO30 0.87 13.02 0.62 2.64e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.76 -9.75 -0.51 2.23e-19 Multiple sclerosis; CESC cis rs12142240 0.698 rs17413701 chr1:46818452 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs2288073 0.965 rs10199334 chr2:24392618 T/C cg06627628 chr2:24431161 ITSN2 -0.78 -8.98 -0.48 5.26e-17 Venous thromboembolism (SNP x SNP interaction); CESC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg11890956 chr21:40555474 PSMG1 1.18 22.6 0.81 9.51e-64 Cognitive function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03770877 chr3:73046015 PPP4R2 0.43 6.57 0.37 2.68e-10 Gut microbiota (bacterial taxa); CESC cis rs9906944 0.707 rs12942084 chr17:47114392 A/G cg09029085 chr17:47094198 IGF2BP1 0.25 5.06 0.3 7.94e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg26939375 chr7:64535504 NA 0.76 10.85 0.55 6.19e-23 Aortic root size; CESC cis rs7635838 0.892 rs9874535 chr3:11463730 A/G cg00170343 chr3:11313890 ATG7 0.43 5.6 0.33 5.24e-8 HDL cholesterol; CESC cis rs9916302 0.904 rs12450559 chr17:37694709 G/A cg20243544 chr17:37824526 PNMT 0.52 6.61 0.38 2.14e-10 Glomerular filtration rate (creatinine); CESC cis rs11677370 0.574 rs10209122 chr2:3871186 C/A cg17052675 chr2:3827356 NA -0.47 -5.86 -0.34 1.35e-8 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15673029 chr19:46234190 FBXO46 0.57 6.27 0.36 1.44e-9 Gut microbiome composition (summer); CESC cis rs8028182 0.636 rs6495182 chr15:75814388 C/T cg20655648 chr15:75932815 IMP3 0.48 5.91 0.34 1.05e-8 Sudden cardiac arrest; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16520737 chr19:1021368 C19orf6 -0.65 -7.59 -0.42 5.36e-13 Gut microbiome composition (summer); CESC trans rs2727020 0.576 rs61885308 chr11:49343363 G/A cg00717180 chr2:96193071 NA -0.44 -6.07 -0.35 4.41e-9 Coronary artery disease; CESC cis rs1729951 0.575 rs1654925 chr3:136690391 C/T cg04103450 chr3:136751342 NA -0.38 -5.05 -0.3 8.18e-7 Neuroticism; CESC cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.24e-9 Extrinsic epigenetic age acceleration; CESC cis rs990171 0.506 rs2041748 chr2:102756295 A/G cg22835712 chr2:102737379 NA 0.44 6.25 0.36 1.65e-9 Lymphocyte counts; CESC cis rs6088590 0.965 rs6119534 chr20:33441257 C/T cg24642439 chr20:33292090 TP53INP2 0.82 11.44 0.57 6.84e-25 Coronary artery disease; CESC cis rs10751667 0.643 rs7479473 chr11:929111 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.26 -0.31 2.96e-7 Alzheimer's disease (late onset); CESC cis rs7666738 0.830 rs7697315 chr4:98938764 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.69 0.33 3.36e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg22920501 chr2:26401640 FAM59B -0.79 -9.3 -0.5 5.61e-18 Gut microbiome composition (summer); CESC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg21248554 chr2:27665150 KRTCAP3 -0.42 -8.7 -0.47 3.67e-16 Total body bone mineral density; CESC cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg22823121 chr1:150693482 HORMAD1 -0.41 -6.09 -0.35 3.95e-9 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27510503 chr22:22012035 NA 0.52 6.3 0.36 1.27e-9 Gut microbiome composition (summer); CESC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg04248312 chr19:17393744 ANKLE1 -0.93 -15.26 -0.68 3.79e-38 Systemic lupus erythematosus; CESC cis rs9858542 0.953 rs11926781 chr3:49603289 C/T cg03060546 chr3:49711283 APEH -0.51 -5.94 -0.34 8.9e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2635047 0.811 rs17723754 chr18:44771481 C/T cg19077165 chr18:44547161 KATNAL2 -0.39 -5.08 -0.3 7.06e-7 Educational attainment; CESC cis rs11190604 1.000 rs2273695 chr10:102259568 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.4 0.31 1.49e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs642858 1.000 rs6933684 chr6:140300384 C/T cg27524944 chr6:140295369 NA 0.36 5.57 0.32 6.19e-8 Type 2 diabetes; CESC cis rs9818758 0.607 rs35108630 chr3:49088356 T/A cg00383909 chr3:49044727 WDR6 0.92 6.59 0.38 2.35e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs6430585 0.941 rs12469551 chr2:136510012 T/G cg07169764 chr2:136633963 MCM6 -0.95 -12.91 -0.62 6.41e-30 Corneal structure; CESC cis rs2985684 0.740 rs2883438 chr14:50044392 T/C cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.44 -5.24 -0.31 3.24e-7 Carotid intima media thickness; CESC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg18876405 chr7:65276391 NA 0.53 7.32 0.41 3.01e-12 Aortic root size; CESC trans rs1493916 0.967 rs9953768 chr18:31399468 A/G cg27147174 chr7:100797783 AP1S1 -0.52 -7.1 -0.4 1.14e-11 Life satisfaction; CESC cis rs1153858 1.000 rs4534782 chr15:45652933 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.97 0.34 7.62e-9 Homoarginine levels; CESC cis rs72781680 0.611 rs72781696 chr2:24267014 C/T cg08917208 chr2:24149416 ATAD2B 0.63 6.09 0.35 3.87e-9 Lymphocyte counts; CESC cis rs826838 0.904 rs10880981 chr12:38763911 G/A cg26384229 chr12:38710491 ALG10B 0.84 14.74 0.67 2.59e-36 Heart rate; CESC cis rs7178572 0.568 rs1446312 chr15:77412189 G/C cg22256960 chr15:77711686 NA -0.53 -6.73 -0.38 1.05e-10 Type 2 diabetes; CESC cis rs57221529 0.766 rs12521988 chr5:556421 C/T cg16447950 chr5:562315 NA -0.7 -7.76 -0.43 1.9e-13 Lung disease severity in cystic fibrosis; CESC cis rs1348850 0.632 rs11682717 chr2:178499240 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 7.54 0.42 7.5e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs727563 0.594 rs132807 chr22:42071584 T/C cg06634786 chr22:41940651 POLR3H 0.62 6.25 0.36 1.67e-9 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25155766 chr12:34317569 NA -0.52 -6.68 -0.38 1.42e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07588614 chr3:113604183 GRAMD1C -0.69 -8.41 -0.46 2.51e-15 Gut microbiome composition (summer); CESC cis rs897080 0.552 rs1067389 chr2:44642290 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.89 0.34 1.14e-8 Height; CESC cis rs7553864 0.835 rs4415539 chr1:87604245 C/T cg17420885 chr1:87600446 LOC339524 0.37 5.26 0.31 2.91e-7 Smoking behavior; CESC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg10691866 chr7:65817282 TPST1 0.32 5.25 0.31 3.06e-7 Aortic root size; CESC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg05527609 chr1:210001259 C1orf107 0.38 5.08 0.3 7.11e-7 Monobrow; CESC cis rs13382862 0.823 rs12710743 chr2:20880714 T/C cg14780466 chr2:20870812 GDF7 -0.46 -7.43 -0.42 1.46e-12 Abdominal aortic aneurysm; CESC cis rs6546550 0.901 rs12232914 chr2:70117176 C/T cg02498382 chr2:70120550 SNRNP27 -0.42 -7.37 -0.41 2.12e-12 Prevalent atrial fibrillation; CESC cis rs9905704 0.801 rs302847 chr17:56687481 C/T cg12560992 chr17:57184187 TRIM37 0.62 7.73 0.43 2.17e-13 Testicular germ cell tumor; CESC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.64 5.54 0.32 7.29e-8 Depression; CESC cis rs12042052 0.793 rs10910624 chr1:232940291 T/A cg00951395 chr1:232941775 KIAA1383 0.53 5.4 0.32 1.46e-7 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs962856 0.756 rs4671799 chr2:67622243 A/G cg09028215 chr2:67624308 ETAA1 -0.44 -5.64 -0.33 4.26e-8 Pancreatic cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13309628 chr20:3801056 C20orf29 0.48 6.14 0.35 3.07e-9 Gut microbiota (bacterial taxa); CESC cis rs6688613 0.545 rs10800270 chr1:166827602 A/T ch.1.3259774R chr1:166827647 TADA1 0.6 6.19 0.36 2.27e-9 Refractive astigmatism; CESC cis rs763121 0.853 rs1013338 chr22:38974154 C/A cg21395723 chr22:39101663 GTPBP1 0.48 6.34 0.36 9.72e-10 Menopause (age at onset); CESC trans rs61931739 0.500 rs7489270 chr12:34432062 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.37 0.54 2.3e-21 Morning vs. evening chronotype; CESC cis rs1030268 0.620 rs2160746 chr7:133478204 G/C cg10665199 chr7:133106180 EXOC4 0.56 5.61 0.33 5.03e-8 Intelligence (multi-trait analysis); CESC cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.75 -11.04 -0.56 1.49e-23 Hip circumference adjusted for BMI; CESC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg00149659 chr3:10157352 C3orf10 0.75 9.56 0.51 8.47e-19 Alzheimer's disease; CESC cis rs7095944 0.614 rs61872084 chr10:126439062 C/T cg08799069 chr10:126477246 METTL10 -0.37 -5.29 -0.31 2.58e-7 Asthma; CESC cis rs1843834 0.574 rs6436499 chr2:225456551 A/T cg22509189 chr2:225307070 NA -0.41 -5.65 -0.33 4.19e-8 IgE levels in asthmatics (D.p. specific); CESC cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg08847533 chr14:75593920 NEK9 -0.91 -15.9 -0.7 1.93e-40 Height; CESC cis rs6963495 0.818 rs117845382 chr7:105152040 T/C cg02135003 chr7:105160482 PUS7 -0.46 -5.46 -0.32 1.08e-7 Bipolar disorder (body mass index interaction); CESC cis rs798766 1.000 rs798755 chr4:1720824 A/G cg10756475 chr4:1757242 NA 0.47 6.56 0.37 2.84e-10 Bladder cancer;Urinary bladder cancer; CESC cis rs826838 1.000 rs826892 chr12:39100790 T/C cg13010199 chr12:38710504 ALG10B -0.4 -5.54 -0.32 7.42e-8 Heart rate; CESC cis rs9916302 0.904 rs2338800 chr17:37498149 C/G cg07936489 chr17:37558343 FBXL20 0.77 11.05 0.56 1.34e-23 Glomerular filtration rate (creatinine); CESC cis rs722599 0.715 rs8008785 chr14:75307600 G/A cg11812906 chr14:75593930 NEK9 -0.43 -5.48 -0.32 9.81e-8 IgG glycosylation; CESC trans rs208520 0.690 rs3846808 chr6:66818604 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -12.35 -0.6 5.52e-28 Exhaled nitric oxide output; CESC cis rs9815354 0.680 rs7649989 chr3:41865843 A/C cg03022575 chr3:42003672 ULK4 0.46 5.29 0.31 2.57e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs6087990 0.899 rs1883729 chr20:31363193 G/A cg13636640 chr20:31349939 DNMT3B 0.92 16.43 0.71 2.65e-42 Ulcerative colitis; CESC cis rs2354432 0.607 rs6683243 chr1:146733422 A/T cg25205988 chr1:146714368 CHD1L -0.95 -7.6 -0.42 5.06e-13 Mitochondrial DNA levels; CESC cis rs1005277 1.000 rs1005277 chr10:38218259 A/C cg25427524 chr10:38739819 LOC399744 0.52 6.44 0.37 5.52e-10 Extrinsic epigenetic age acceleration; CESC cis rs1538970 0.962 rs2487442 chr1:45857176 C/G cg05343316 chr1:45956843 TESK2 -0.76 -10.59 -0.55 4.53e-22 Platelet count; CESC cis rs66887589 0.777 rs2017058 chr4:120257739 T/C cg09307838 chr4:120376055 NA 0.55 7.48 0.42 1.11e-12 Diastolic blood pressure; CESC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg18099408 chr3:52552593 STAB1 -0.31 -5.09 -0.3 6.68e-7 Bipolar disorder; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg27069263 chr2:55278118 RTN4 0.45 5.99 0.35 6.64e-9 Neuroticism; CESC cis rs4332037 0.624 rs11766944 chr7:1888051 G/A cg23422044 chr7:1970798 MAD1L1 -0.54 -5.79 -0.34 1.99e-8 Bipolar disorder; CESC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg00074818 chr8:8560427 CLDN23 0.36 5.24 0.31 3.32e-7 Obesity-related traits; CESC cis rs6963495 0.818 rs116457537 chr7:105152072 A/G cg02135003 chr7:105160482 PUS7 -0.46 -5.46 -0.32 1.08e-7 Bipolar disorder (body mass index interaction); CESC cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg00825309 chr19:58991885 ZNF446 -0.54 -7.71 -0.43 2.62e-13 Uric acid clearance; CESC cis rs936229 0.813 rs4886619 chr15:75106138 C/T cg14664628 chr15:75095509 CSK -0.98 -15.61 -0.69 2.13e-39 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs7843479 1.000 rs727694 chr8:21849962 T/C cg17168535 chr8:21777572 XPO7 0.48 6.7 0.38 1.26e-10 Mean corpuscular volume; CESC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg05132306 chr1:1846340 CALML6 -0.29 -6.01 -0.35 6.22e-9 Body mass index; CESC cis rs7584330 0.737 rs1390985 chr2:238367420 G/A cg14458575 chr2:238380390 NA 0.6 8.14 0.45 1.56e-14 Prostate cancer; CESC cis rs2637266 1.000 rs2579761 chr10:78321040 C/T cg18941641 chr10:78392320 NA 0.38 7.06 0.4 1.46e-11 Pulmonary function; CESC cis rs919433 0.963 rs10166569 chr2:198183439 G/A cg03934865 chr2:198174659 NA -0.4 -5.4 -0.31 1.48e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7072216 0.763 rs10736129 chr10:100171571 C/T cg26618903 chr10:100175079 PYROXD2 0.4 6.2 0.36 2.1e-9 Metabolite levels; CESC cis rs561341 1.000 rs7214017 chr17:30332220 T/C cg00745463 chr17:30367425 LRRC37B -0.69 -6.99 -0.39 2.25e-11 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00338229 chr19:46088275 OPA3 0.63 7.32 0.41 3.03e-12 Gut microbiome composition (summer); CESC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg17372223 chr3:52568218 NT5DC2 0.37 5.2 0.3 3.97e-7 Bipolar disorder; CESC cis rs1371867 0.846 rs2453624 chr8:101230523 A/G cg11906718 chr8:101322791 RNF19A -0.5 -6.19 -0.36 2.22e-9 Atrioventricular conduction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04073819 chr3:133293165 CDV3 0.66 7.2 0.4 6.38e-12 Gut microbiome composition (summer); CESC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg24101359 chr6:42928495 GNMT 0.56 7.98 0.44 4.36e-14 Alzheimer's disease in APOE e4+ carriers; CESC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg26335602 chr6:28129616 ZNF389 0.54 7.3 0.41 3.37e-12 Depression; CESC cis rs9910055 0.530 rs2269905 chr17:42294462 A/G cg13607699 chr17:42295918 UBTF 0.81 12.25 0.6 1.22e-27 Total body bone mineral density; CESC cis rs2073300 0.609 rs6137936 chr20:23385232 C/T cg12062639 chr20:23401060 NAPB 1.07 8.85 0.48 1.29e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2191566 0.960 rs2270196 chr19:44506623 A/G cg20607764 chr19:44506953 ZNF230 0.55 7.13 0.4 9.83e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs6570726 0.967 rs439017 chr6:145806123 T/C cg23711669 chr6:146136114 FBXO30 0.77 11.23 0.57 3.42e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs910316 0.967 rs4899550 chr14:75647666 C/T cg11812906 chr14:75593930 NEK9 -0.84 -13.44 -0.64 9.06e-32 Height; CESC cis rs1729951 0.575 rs361242 chr3:136698330 C/G cg04103450 chr3:136751342 NA 0.4 5.36 0.31 1.78e-7 Neuroticism; CESC cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg00033643 chr7:134001901 SLC35B4 0.41 5.28 0.31 2.67e-7 Mean platelet volume; CESC cis rs9303401 0.659 rs35539277 chr17:56853833 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.02 11.44 0.57 6.89e-25 Cognitive test performance; CESC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg09365446 chr1:150670422 GOLPH3L 0.4 5.37 0.31 1.69e-7 Melanoma; CESC cis rs6582630 0.537 rs6582500 chr12:38534206 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.84 0.39 5.44e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs7223966 1.000 rs9912201 chr17:61763208 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 6.12 0.35 3.43e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.34 0.41 2.56e-12 Tonsillectomy; CESC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg06453172 chr10:134556979 INPP5A -0.42 -5.42 -0.32 1.35e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2415984 0.579 rs2254846 chr14:46973394 G/A cg14871534 chr14:47121158 RPL10L 0.35 5.32 0.31 2.24e-7 Number of children ever born; CESC cis rs9467711 0.606 rs34550936 chr6:26361985 A/G cg12826209 chr6:26865740 GUSBL1 0.62 5.4 0.32 1.45e-7 Autism spectrum disorder or schizophrenia; CESC cis rs1348850 0.574 rs12988366 chr2:178417945 A/C cg23306229 chr2:178417860 TTC30B -0.74 -6.8 -0.39 6.9e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg14875093 chr19:38398164 WDR87;SIPA1L3 0.61 6.34 0.36 9.77e-10 Diastolic blood pressure; CESC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.38 2.06e-10 Lung cancer; CESC cis rs7408868 1.000 rs7247835 chr19:15262844 A/G cg14696996 chr19:15285081 NOTCH3 1.12 11.59 0.58 2.09e-25 Pulse pressure; CESC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg20243544 chr17:37824526 PNMT 0.45 5.64 0.33 4.28e-8 Glomerular filtration rate (creatinine); CESC cis rs2455799 0.573 rs2455833 chr3:15752830 T/C cg16303742 chr3:15540471 COLQ -0.39 -6.19 -0.36 2.31e-9 Mean platelet volume; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg00670742 chr2:87034831 CD8A 0.5 6.25 0.36 1.66e-9 Psoriatic arthritis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06594919 chr10:102827590 NA 0.46 6.09 0.35 3.85e-9 Gut microbiota (bacterial taxa); CESC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.47 0.77 5.16e-53 Height; CESC cis rs76917914 0.820 rs2281732 chr9:100845007 A/G cg03040243 chr9:100819229 NANS 0.49 5.48 0.32 9.69e-8 Immature fraction of reticulocytes; CESC cis rs4862750 0.872 rs13101380 chr4:187894744 G/A cg03452623 chr4:187889614 NA -0.94 -18.94 -0.76 3.59e-51 Lobe attachment (rater-scored or self-reported); CESC cis rs2243480 0.614 rs34032527 chr7:65565141 C/G cg12463550 chr7:65579703 CRCP 0.74 5.71 0.33 3.02e-8 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23262030 chr17:45918702 SCRN2 0.59 6.7 0.38 1.25e-10 Gut microbiome composition (summer); CESC cis rs910316 0.763 rs175044 chr14:75472109 G/A cg16144293 chr14:75469539 EIF2B2 0.41 5.36 0.31 1.81e-7 Height; CESC cis rs826838 0.616 rs10880738 chr12:38617762 C/T cg26384229 chr12:38710491 ALG10B -0.43 -5.65 -0.33 4.09e-8 Heart rate; CESC cis rs6541297 0.703 rs1264081 chr1:230311176 A/G cg20703242 chr1:230279135 GALNT2 -0.42 -5.45 -0.32 1.12e-7 Coronary artery disease; CESC cis rs28829049 0.566 rs59681755 chr1:19528985 G/A cg13387374 chr1:19411106 UBR4 0.44 5.61 0.33 5.16e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg24399712 chr22:39784796 NA -0.83 -11.46 -0.58 5.61e-25 Intelligence (multi-trait analysis); CESC cis rs61996546 0.622 rs34660647 chr15:26841524 T/C cg15066197 chr15:26874202 GABRB3 -0.35 -5.15 -0.3 5.06e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12037538 chr1:25664880 TMEM50A -0.49 -6.44 -0.37 5.68e-10 Asthma; CESC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.1 -0.35 3.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs72781680 0.898 rs12622290 chr2:23979894 C/G cg20701182 chr2:24300061 SF3B14 0.63 5.54 0.32 7.13e-8 Lymphocyte counts; CESC cis rs12900413 0.687 rs11629590 chr15:90304644 A/G cg24249390 chr15:90295951 MESP1 0.43 6.2 0.36 2.15e-9 Coronary artery aneurysm in Kawasaki disease; CESC cis rs6728642 1.000 rs80303184 chr2:98024633 G/A cg26665480 chr2:98280029 ACTR1B -0.93 -6.33 -0.36 1.04e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs748404 0.660 rs690512 chr15:43717678 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.13 0.45 1.61e-14 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26187342 chr17:65713858 NOL11 0.64 7.41 0.41 1.68e-12 Gut microbiome composition (summer); CESC cis rs3749237 0.595 rs4855859 chr3:49526300 C/T cg06212747 chr3:49208901 KLHDC8B 0.49 6.55 0.37 3.02e-10 Resting heart rate; CESC cis rs2425143 1.000 rs60646509 chr20:34303409 T/G cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.14 0.3 5.33e-7 Blood protein levels; CESC cis rs7520050 0.966 rs61783220 chr1:46335312 G/A cg03146154 chr1:46216737 IPP -0.49 -6.37 -0.36 8.44e-10 Red blood cell count;Reticulocyte count; CESC cis rs11785400 0.793 rs4736367 chr8:143742477 G/A cg24634471 chr8:143751801 JRK 0.45 5.75 0.33 2.41e-8 Schizophrenia; CESC cis rs6032067 1.000 rs6032066 chr20:43857700 C/T cg10761708 chr20:43804764 PI3 0.52 6.29 0.36 1.34e-9 Blood protein levels; CESC cis rs2404602 0.647 rs8025991 chr15:77155268 C/T cg23625390 chr15:77176239 SCAPER -0.43 -5.94 -0.34 9.08e-9 Blood metabolite levels; CESC cis rs17818399 0.716 rs62134741 chr2:46782189 G/A cg06386533 chr2:46925753 SOCS5 0.46 5.04 0.3 8.74e-7 Height; CESC cis rs7777754 0.512 rs3757472 chr7:50537983 A/C cg14593290 chr7:50529359 DDC -0.38 -5.5 -0.32 8.78e-8 Response to zileuton treatment in asthma (FEV1 change interaction); CESC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg27535305 chr1:53392650 SCP2 -0.34 -5.59 -0.32 5.68e-8 Monocyte count; CESC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg09365446 chr1:150670422 GOLPH3L 0.39 5.23 0.31 3.44e-7 Melanoma; CESC cis rs4888262 0.526 rs7191754 chr16:74610850 G/T cg01733217 chr16:74700730 RFWD3 0.82 11.28 0.57 2.33e-24 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg24675658 chr1:53192096 ZYG11B -0.46 -5.68 -0.33 3.55e-8 Monocyte count; CESC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg02592271 chr2:27665507 KRTCAP3 0.33 6.89 0.39 3.98e-11 Total body bone mineral density; CESC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.73 6.38 0.36 7.86e-10 Platelet count; CESC cis rs9911578 0.934 rs58092632 chr17:57111101 T/C cg05425664 chr17:57184151 TRIM37 0.52 7.19 0.4 6.63e-12 Intelligence (multi-trait analysis); CESC cis rs72634258 0.503 rs697674 chr1:7837878 C/G cg26816564 chr1:7831052 VAMP3 0.64 6.61 0.38 2.13e-10 Inflammatory bowel disease; CESC cis rs820218 0.607 rs820168 chr17:73721365 G/C cg01592526 chr17:73663357 RECQL5;SAP30BP 0.41 5.03 0.3 8.89e-7 Rotator cuff tears; CESC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg00684032 chr4:1343700 KIAA1530 0.4 5.56 0.32 6.51e-8 Obesity-related traits; CESC cis rs1005277 0.522 rs7072977 chr10:37940440 C/A cg25517755 chr10:38738941 LOC399744 -0.42 -5.52 -0.32 8.28e-8 Extrinsic epigenetic age acceleration; CESC cis rs2011503 1.000 rs11670882 chr19:19649748 C/G cg03709012 chr19:19516395 GATAD2A 0.52 5.39 0.31 1.54e-7 Bipolar disorder; CESC cis rs2952156 0.920 rs2517958 chr17:37838751 G/A cg20243544 chr17:37824526 PNMT 0.62 8.16 0.45 1.36e-14 Asthma; CESC cis rs9398803 0.865 rs2184968 chr6:126760994 A/G cg19875578 chr6:126661172 C6orf173 0.48 6.88 0.39 4.37e-11 Male-pattern baldness; CESC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.53 -0.42 7.92e-13 Gut microbiome composition (summer); CESC cis rs12530845 1.000 rs73721606 chr7:135335678 C/T cg23117316 chr7:135346802 PL-5283 -0.41 -5.24 -0.31 3.35e-7 Red blood cell traits; CESC cis rs4481887 0.772 rs4916127 chr1:248466615 A/G cg00666640 chr1:248458726 OR2T12 0.39 6.37 0.36 8.47e-10 Common traits (Other); CESC cis rs977987 0.806 rs11640473 chr16:75403289 C/A cg03315344 chr16:75512273 CHST6 0.4 5.74 0.33 2.59e-8 Dupuytren's disease; CESC cis rs7212590 0.581 rs28539312 chr17:57834602 A/C cg20303301 chr17:57937339 TUBD1 -0.55 -5.18 -0.3 4.34e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg24829409 chr8:58192753 C8orf71 -0.75 -9.74 -0.51 2.37e-19 Developmental language disorder (linguistic errors); CESC cis rs4835473 0.900 rs11100810 chr4:144708671 C/T cg25736465 chr4:144833511 NA -0.33 -5.43 -0.32 1.28e-7 Immature fraction of reticulocytes; CESC cis rs881375 0.902 rs2900180 chr9:123706382 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 5.43 0.32 1.25e-7 Rheumatoid arthritis; CESC cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs372883 0.600 rs2832294 chr21:30739671 A/C cg08807101 chr21:30365312 RNF160 0.46 5.31 0.31 2.28e-7 Pancreatic cancer; CESC cis rs2295499 0.610 rs2239726 chr4:2697089 A/C cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.18 -0.3 4.41e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.66 -8.75 -0.47 2.57e-16 Prudent dietary pattern; CESC cis rs9929218 1.000 rs8044058 chr16:68807088 G/A cg02972257 chr16:68554789 NA 0.48 5.73 0.33 2.71e-8 Colorectal cancer; CESC cis rs17253792 0.822 rs112418863 chr14:56114079 G/A cg01858014 chr14:56050164 KTN1 -0.96 -7.52 -0.42 8.3e-13 Putamen volume; CESC cis rs8058578 1.000 rs13338946 chr16:30700858 T/C cg02466173 chr16:30829666 NA -0.45 -7.19 -0.4 6.43e-12 Multiple myeloma; CESC cis rs3857067 0.934 rs1509941 chr4:95018784 T/C cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.53 -0.42 8.12e-13 QT interval; CESC cis rs2235642 0.928 rs56289115 chr16:1608934 A/G cg07639376 chr16:1584516 IFT140;TMEM204 -0.32 -5.29 -0.31 2.61e-7 Coronary artery disease; CESC trans rs1814175 0.817 rs4881658 chr11:49941123 G/A cg03929089 chr4:120376271 NA -0.93 -15.62 -0.69 1.93e-39 Height; CESC cis rs9733 0.687 rs11204735 chr1:150841667 T/C cg22823121 chr1:150693482 HORMAD1 -0.37 -5.45 -0.32 1.15e-7 Tonsillectomy; CESC cis rs7824557 0.701 rs2060465 chr8:11162609 T/C cg21775007 chr8:11205619 TDH 0.5 7.29 0.41 3.6e-12 Retinal vascular caliber; CESC trans rs561341 0.714 rs75861674 chr17:30304317 A/G cg20587970 chr11:113659929 NA -1.09 -13.78 -0.65 5.92e-33 Hip circumference adjusted for BMI; CESC cis rs7223966 1.000 rs9747164 chr17:61864787 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.16 0.35 2.69e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2795502 1.000 rs2185717 chr10:43343875 G/A cg27426351 chr10:43362370 NA 0.48 6.09 0.35 3.85e-9 Blood protein levels; CESC cis rs9443645 0.505 rs9359364 chr6:79795992 G/A cg05283184 chr6:79620031 NA -0.37 -5.38 -0.31 1.61e-7 Intelligence (multi-trait analysis); CESC cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg03433033 chr1:76189801 ACADM -0.62 -6.54 -0.37 3.12e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9768139 0.733 rs12698209 chr7:158117595 A/G cg24154853 chr7:158122151 PTPRN2 -0.43 -7.01 -0.4 1.96e-11 Calcium levels; CESC cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 5.97 0.34 7.63e-9 Eosinophil percentage of white cells; CESC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.8 -10.99 -0.56 2.18e-23 Alzheimer's disease; CESC cis rs66887589 0.934 rs7681980 chr4:120533223 G/A cg09307838 chr4:120376055 NA -0.48 -6.52 -0.37 3.53e-10 Diastolic blood pressure; CESC trans rs17181170 0.536 rs13064285 chr3:87208121 A/T ch.2.199792288R chr2:200084043 NA -0.46 -6.1 -0.35 3.78e-9 Prostate cancer; CESC cis rs6570726 0.905 rs377143 chr6:145834220 C/T cg05347473 chr6:146136440 FBXO30 0.44 5.96 0.34 8.05e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg24675658 chr1:53192096 ZYG11B -0.6 -7.7 -0.43 2.64e-13 Monocyte count; CESC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.9 0.39 3.79e-11 Bipolar disorder; CESC cis rs2952156 0.920 rs9675194 chr17:37833805 A/G cg07936489 chr17:37558343 FBXL20 -0.6 -8.1 -0.45 1.97e-14 Asthma; CESC cis rs72781680 1.000 rs115861480 chr2:24129464 T/A cg08917208 chr2:24149416 ATAD2B 1.1 9.84 0.52 1.09e-19 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00503587 chr20:18118441 PET117 0.6 6.58 0.37 2.53e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04843851 chr14:71067415 MED6 0.63 6.83 0.39 5.9e-11 Gut microbiome composition (summer); CESC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg26769984 chr7:1090371 C7orf50 0.54 6.33 0.36 1.02e-9 Bronchopulmonary dysplasia; CESC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg26752003 chr8:145688521 CYHR1 0.46 6.49 0.37 4.11e-10 Age at first birth; CESC cis rs12477438 0.520 rs2516827 chr2:99772565 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.46 0.69 7.45e-39 Chronic sinus infection; CESC cis rs9322193 0.884 rs7769115 chr6:150169932 C/T cg07701084 chr6:150067640 NUP43 0.39 5.1 0.3 6.36e-7 Lung cancer; CESC cis rs8077577 0.708 rs59366579 chr17:18161744 C/T cg16794390 chr17:18148240 FLII 0.38 5.94 0.34 9.03e-9 Obesity-related traits; CESC cis rs7605827 0.930 rs6745731 chr2:15537915 C/T cg19274914 chr2:15703543 NA 0.35 6.3 0.36 1.25e-9 Educational attainment (years of education); CESC cis rs11098499 0.954 rs3733519 chr4:120423448 A/G cg09307838 chr4:120376055 NA 0.92 13.01 0.62 3.03e-30 Corneal astigmatism; CESC trans rs10028773 0.515 rs9994488 chr4:120587781 C/T cg25214090 chr10:38739885 LOC399744 0.57 7.94 0.44 5.8e-14 Educational attainment; CESC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg08499158 chr17:42289980 UBTF 0.48 5.98 0.34 7.14e-9 Total body bone mineral density; CESC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg04414720 chr1:150670196 GOLPH3L 0.62 8.8 0.48 1.76e-16 Tonsillectomy; CESC cis rs2425143 0.687 rs6119649 chr20:34369596 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.8 7.75 0.43 1.96e-13 Blood protein levels; CESC cis rs2742234 0.541 rs10793426 chr10:43745280 G/A cg15436174 chr10:43711423 RASGEF1A 0.46 5.33 0.31 2.14e-7 Hirschsprung disease; CESC cis rs9899728 0.539 rs113775187 chr17:73047290 A/G cg27626185 chr17:73056755 KCTD2 -0.89 -8.01 -0.44 3.55e-14 Alzheimer's disease or small vessel stroke; CESC cis rs208520 0.690 rs3843513 chr6:66836797 A/G cg07460842 chr6:66804631 NA -0.98 -13.27 -0.63 3.6e-31 Exhaled nitric oxide output; CESC cis rs9300255 0.506 rs61388686 chr12:123810873 G/A cg00376283 chr12:123451042 ABCB9 0.56 7.64 0.42 3.92e-13 Neutrophil percentage of white cells; CESC trans rs11098499 0.818 rs55825515 chr4:120486402 A/G cg25214090 chr10:38739885 LOC399744 0.65 8.78 0.47 2e-16 Corneal astigmatism; CESC cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs7224314 1.000 rs7226214 chr17:65383323 C/T cg01507342 chr17:65387096 PITPNC1 -0.48 -5.68 -0.33 3.45e-8 Diisocyanate-induced asthma; CESC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg18758796 chr5:131593413 PDLIM4 -0.42 -5.82 -0.34 1.72e-8 Breast cancer; CESC cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.44 0.32 1.24e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1568889 0.838 rs1483858 chr11:28189639 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 12.87 0.62 8.97e-30 Bipolar disorder; CESC cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg06713675 chr4:122721982 EXOSC9 -0.46 -6.59 -0.38 2.37e-10 Type 2 diabetes; CESC cis rs523522 0.962 rs4767903 chr12:120930046 G/A cg27279351 chr12:120934652 DYNLL1 0.69 8.87 0.48 1.1e-16 High light scatter reticulocyte count; CESC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg06873352 chr17:61820015 STRADA 0.72 12.8 0.62 1.61e-29 Prudent dietary pattern; CESC trans rs17685 0.753 rs11972240 chr7:75694079 A/C cg19862616 chr7:65841803 NCRNA00174 0.82 12.16 0.6 2.58e-27 Coffee consumption;Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23713156 chr17:80606235 WDR45L 0.56 6.68 0.38 1.37e-10 Gut microbiome composition (summer); CESC cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.7 11.14 0.56 7.03e-24 Personality dimensions; CESC cis rs10088262 0.540 rs6988602 chr8:124788502 C/T cg15047889 chr8:124780837 FAM91A1 0.48 5.63 0.33 4.63e-8 Pancreatic cancer; CESC cis rs1707322 0.752 rs12024590 chr1:46127496 A/C cg03146154 chr1:46216737 IPP 0.82 11.51 0.58 3.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7940866 0.874 rs1433979 chr11:130871617 G/A cg12179176 chr11:130786555 SNX19 0.64 8.94 0.48 7.05e-17 Schizophrenia; CESC cis rs6732160 0.588 rs72841902 chr2:73372212 T/A cg01422370 chr2:73384389 NA 0.56 8.95 0.48 6.23e-17 Intelligence (multi-trait analysis); CESC trans rs7246657 0.943 rs7252346 chr19:37914682 G/A cg01833234 chr11:6592585 DNHD1 0.52 6.0 0.35 6.5e-9 Coronary artery calcification; CESC cis rs7666738 0.830 rs17548431 chr4:98923768 C/G cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.576 rs11519979 chr12:37999413 C/T cg13010199 chr12:38710504 ALG10B 0.54 6.71 0.38 1.15e-10 Bladder cancer; CESC cis rs9291683 0.609 rs3796836 chr4:10011345 A/G cg11266682 chr4:10021025 SLC2A9 0.7 14.61 0.67 7.23e-36 Bone mineral density; CESC cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.21e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3740540 0.507 rs942014 chr10:126290070 C/T cg04949429 chr10:126290192 LHPP 0.4 5.49 0.32 9.52e-8 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs7259376 0.902 rs7248242 chr19:22575994 A/G cg02657401 chr19:22469223 NA 0.26 5.16 0.3 4.86e-7 Menopause (age at onset); CESC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg05564831 chr3:52568323 NT5DC2 0.45 6.97 0.39 2.55e-11 Bipolar disorder; CESC cis rs8067545 0.586 rs8080649 chr17:20069677 G/C cg13482628 chr17:19912719 NA 0.44 5.89 0.34 1.17e-8 Schizophrenia; CESC cis rs11235843 0.602 rs7106773 chr11:73383174 C/G cg18195628 chr11:73498948 MRPL48 -0.5 -5.38 -0.31 1.67e-7 Hand grip strength; CESC cis rs367615 0.731 rs58241713 chr5:108853664 G/A cg17395555 chr5:108820864 NA 0.55 9.01 0.48 4.09e-17 Colorectal cancer (SNP x SNP interaction); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00366814 chr2:75061219 HK2 -0.49 -6.25 -0.36 1.61e-9 Ulcerative colitis; CESC cis rs4253772 0.591 rs6008546 chr22:46686377 T/G cg24881330 chr22:46731750 TRMU 0.82 7.66 0.43 3.61e-13 LDL cholesterol;Cholesterol, total; CESC trans rs7945705 0.818 rs1988708 chr11:8882893 C/A cg10637292 chr12:52960529 KRT74 0.36 6.26 0.36 1.54e-9 Hemoglobin concentration; CESC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg05564831 chr3:52568323 NT5DC2 0.38 5.95 0.34 8.32e-9 Electroencephalogram traits; CESC cis rs1044826 0.642 rs9826544 chr3:139162831 A/G cg00490450 chr3:139108681 COPB2 0.41 5.04 0.3 8.84e-7 Obesity-related traits; CESC cis rs17818399 0.890 rs34544165 chr2:46836906 A/G cg06386533 chr2:46925753 SOCS5 0.45 5.19 0.3 4.21e-7 Height; CESC cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg27347728 chr4:17578864 LAP3 0.46 5.49 0.32 9.24e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11864453 0.927 rs1035560 chr16:72032730 T/C cg16558253 chr16:72132732 DHX38 -0.46 -6.63 -0.38 1.83e-10 Fibrinogen levels; CESC cis rs2901656 0.544 rs6658843 chr1:172399082 G/C cg03748243 chr1:172413542 C1orf105;PIGC 0.47 6.66 0.38 1.53e-10 Red cell distribution width;Platelet distribution width; CESC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg20811857 chr17:78079795 GAA 0.37 5.91 0.34 1.06e-8 Yeast infection; CESC trans rs629535 0.551 rs62513429 chr8:70149995 A/C cg21567404 chr3:27674614 NA -0.83 -9.14 -0.49 1.69e-17 Dupuytren's disease; CESC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg11890956 chr21:40555474 PSMG1 -0.63 -8.56 -0.47 9.12e-16 Menarche (age at onset); CESC cis rs10779751 0.770 rs1148480 chr1:11172006 A/G cg08854313 chr1:11322531 MTOR 0.85 12.23 0.6 1.46e-27 Body mass index; CESC cis rs13266463 0.830 rs7014552 chr8:143410423 A/G cg16886403 chr8:143471632 TSNARE1 0.44 5.5 0.32 8.78e-8 Schizophrenia; CESC cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs77741769 0.571 rs869781 chr12:121340246 T/C cg02419362 chr12:121203948 SPPL3 0.35 5.6 0.33 5.35e-8 Mean corpuscular volume; CESC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg04166393 chr7:2884313 GNA12 0.61 8.24 0.45 8.02e-15 Height; CESC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg02725872 chr8:58115012 NA -0.42 -5.88 -0.34 1.25e-8 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.588 rs6534149 chr4:120559292 T/G cg09307838 chr4:120376055 NA -0.62 -8.1 -0.45 2.02e-14 Corneal astigmatism; CESC cis rs1971256 0.500 rs17081325 chr6:151817992 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.63 6.01 0.35 6.14e-9 Endometriosis; CESC cis rs10924309 0.737 rs1122734 chr1:245853336 A/T cg00036263 chr1:245852353 KIF26B -0.53 -6.87 -0.39 4.45e-11 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs7216064 1.000 rs62084251 chr17:65878736 G/A cg12091567 chr17:66097778 LOC651250 -0.86 -8.82 -0.48 1.55e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2011503 0.941 rs72999068 chr19:19380685 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 5.04 0.3 8.44e-7 Bipolar disorder; CESC cis rs10751667 0.643 rs10794352 chr11:946294 T/C cg20946044 chr11:1010712 AP2A2 -0.38 -5.29 -0.31 2.63e-7 Alzheimer's disease (late onset); CESC cis rs63406760 1 rs63406760 chr12:123742692 TG/T cg05973401 chr12:123451056 ABCB9 0.49 5.52 0.32 8.03e-8 Allergic disease (asthma, hay fever or eczema); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17535283 chr2:26541115 GPR113 0.47 6.79 0.38 7.28e-11 Gut microbiota (bacterial taxa); CESC cis rs2859741 0.967 rs522481 chr1:37488337 C/T cg09363841 chr1:37513479 NA -0.66 -10.52 -0.54 7.37e-22 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.2.195648145F chr2:195939902 NA -0.51 -6.47 -0.37 4.59e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs728616 0.681 rs55855057 chr10:82034729 G/A cg27171509 chr10:82033454 MAT1A -0.41 -5.08 -0.3 7.16e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs4780401 0.609 rs12927966 chr16:11814562 C/T cg01061890 chr16:11836724 TXNDC11 -0.56 -7.52 -0.42 8.36e-13 Rheumatoid arthritis; CESC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg24549020 chr5:56110836 MAP3K1 0.6 7.0 0.39 2.12e-11 Initial pursuit acceleration; CESC cis rs17253792 0.822 rs111467375 chr14:56046159 T/G cg01858014 chr14:56050164 KTN1 -0.99 -7.44 -0.42 1.43e-12 Putamen volume; CESC trans rs561341 0.609 rs9906443 chr17:30185565 C/T cg20587970 chr11:113659929 NA 0.6 7.28 0.41 3.78e-12 Hip circumference adjusted for BMI; CESC cis rs7843479 0.562 rs11774629 chr8:21859315 C/T cg17168535 chr8:21777572 XPO7 0.73 11.55 0.58 2.81e-25 Mean corpuscular volume; CESC cis rs929596 0.785 rs34352510 chr2:234650562 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.69 -8.69 -0.47 3.81e-16 Total bilirubin levels in HIV-1 infection; CESC cis rs6032067 0.929 rs62208428 chr20:43827578 A/C cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.53e-7 Blood protein levels; CESC cis rs62432291 0.681 rs2501177 chr6:159655593 C/T cg14500486 chr6:159655392 FNDC1 -0.62 -6.21 -0.36 2.04e-9 Joint mobility (Beighton score); CESC cis rs1044826 0.642 rs295478 chr3:139223135 G/A cg00490450 chr3:139108681 COPB2 0.45 5.53 0.32 7.8e-8 Obesity-related traits; CESC cis rs7116495 0.881 rs7930544 chr11:71737354 C/T cg26138937 chr11:71823887 C11orf51 -0.77 -6.19 -0.36 2.3e-9 Severe influenza A (H1N1) infection; CESC cis rs2795502 1.000 rs1852959 chr10:43359636 T/C cg20628663 chr10:43360327 NA 0.59 6.89 0.39 4.13e-11 Blood protein levels; CESC cis rs9815354 1.000 rs56207540 chr3:41976627 G/C cg03022575 chr3:42003672 ULK4 0.67 5.96 0.34 7.91e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs16854884 0.632 rs62267390 chr3:143644067 A/T cg06585982 chr3:143692056 C3orf58 0.54 7.1 0.4 1.15e-11 Economic and political preferences (feminism/equality); CESC cis rs62408225 1.000 rs2021716 chr6:90941289 C/T cg06866423 chr6:90926672 BACH2 0.47 5.82 0.34 1.71e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg00149659 chr3:10157352 C3orf10 0.75 9.08 0.49 2.62e-17 Alzheimer's disease; CESC cis rs2832191 0.716 rs9983051 chr21:30371890 C/T cg08807101 chr21:30365312 RNF160 0.96 14.87 0.67 8.67e-37 Dental caries; CESC cis rs2251381 0.606 rs8129515 chr21:30520167 C/G cg24692254 chr21:30365293 RNF160 0.74 10.28 0.53 4.57e-21 Selective IgA deficiency; CESC trans rs13098911 0.540 rs34000569 chr3:45999209 A/G cg10236987 chr1:228114221 WNT9A 0.57 6.07 0.35 4.38e-9 Celiac disease; CESC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg22920501 chr2:26401640 FAM59B -0.78 -9.87 -0.52 9.31e-20 Gut microbiome composition (summer); CESC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg12463550 chr7:65579703 CRCP -0.47 -5.99 -0.35 6.85e-9 Aortic root size; CESC trans rs5758511 0.689 rs11913578 chr22:42347391 A/C cg15080870 chr19:47770746 CCDC9 0.5 6.27 0.36 1.42e-9 Birth weight; CESC cis rs7223966 1.000 rs8070650 chr17:61744040 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.44 0.37 5.7e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs12534701 0.904 rs3800577 chr7:154673469 G/T cg24255201 chr7:154684926 DPP6 0.5 6.67 0.38 1.5e-10 Colorectal cancer (diet interaction); CESC cis rs10979 1.000 rs9386034 chr6:143890572 T/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs4595586 0.525 rs11611705 chr12:39426828 C/T cg26384229 chr12:38710491 ALG10B 0.59 7.99 0.44 4.27e-14 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23879496 chr6:43749477 VEGFA -0.57 -6.6 -0.38 2.17e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.546 rs28590002 chr4:98722642 C/T cg17366294 chr4:99064904 C4orf37 0.53 6.66 0.38 1.61e-10 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00205436 chr2:132766767 NA -0.41 -6.82 -0.39 6.02e-11 Gut microbiota (bacterial taxa); CESC cis rs4566357 0.615 rs4675140 chr2:227908665 C/T cg11843606 chr2:227700838 RHBDD1 -0.49 -6.49 -0.37 4.28e-10 Coronary artery disease; CESC cis rs611744 0.506 rs13280454 chr8:109263240 A/G cg21045802 chr8:109455806 TTC35 0.49 6.09 0.35 3.98e-9 Dupuytren's disease; CESC cis rs832540 0.806 rs10039322 chr5:56260259 A/C cg24531977 chr5:56204891 C5orf35 -0.4 -5.13 -0.3 5.72e-7 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16256065 chr11:68216328 LRP5 0.49 6.98 0.39 2.43e-11 Fibrinogen levels; CESC cis rs501120 1.000 rs1746047 chr10:44774086 T/G cg09554077 chr10:44749378 NA 0.52 6.94 0.39 3.05e-11 Coronary artery disease;Coronary heart disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24005950 chr16:2012498 SNORA10;RPS2 0.42 6.15 0.35 2.77e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12681366 0.663 rs2043987 chr8:95469693 G/C cg13257157 chr8:95487014 RAD54B 0.39 5.34 0.31 2.04e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg07493874 chr5:1342172 CLPTM1L -0.41 -7.73 -0.43 2.26e-13 Lung cancer; CESC cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg23711669 chr6:146136114 FBXO30 1.02 15.94 0.7 1.48e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs3749237 0.595 rs3870337 chr3:49557095 G/T cg06212747 chr3:49208901 KLHDC8B 0.49 6.63 0.38 1.92e-10 Resting heart rate; CESC cis rs3749237 0.595 rs17595772 chr3:49409704 G/A cg03060546 chr3:49711283 APEH 0.75 11.29 0.57 2.23e-24 Resting heart rate; CESC cis rs12477438 0.765 rs62156363 chr2:99693324 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg21770322 chr7:97807741 LMTK2 0.54 8.13 0.45 1.67e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.32 0.31 2.23e-7 Bipolar disorder; CESC cis rs7772486 0.686 rs9403746 chr6:146103768 C/A cg23711669 chr6:146136114 FBXO30 -0.9 -13.54 -0.64 4.32e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg24450063 chr1:156163899 SLC25A44 1.11 23.35 0.82 2.92e-66 Testicular germ cell tumor; CESC cis rs7017914 0.967 rs7000647 chr8:71688408 C/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs7927771 0.524 rs10838739 chr11:47672743 A/G cg20307385 chr11:47447363 PSMC3 -0.6 -8.52 -0.46 1.24e-15 Subjective well-being; CESC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC trans rs17536732 0.605 rs466478 chr4:162900278 A/G cg11413039 chr11:125774447 PUS3;DDX25 -0.59 -6.47 -0.37 4.74e-10 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs3126085 0.735 rs35061954 chr1:152240583 G/T cg03465714 chr1:152285911 FLG -0.44 -5.49 -0.32 9.57e-8 Atopic dermatitis; CESC cis rs71403859 0.502 rs34766979 chr16:71475511 G/A cg08717414 chr16:71523259 ZNF19 -1.01 -9.45 -0.5 1.9e-18 Post bronchodilator FEV1; CESC cis rs17345786 0.602 rs11923273 chr3:101337863 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.44 5.5 0.32 9.05e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21733363 chr11:62623427 SNORD27;SLC3A2;SNORD28;SNORD25;SNORD26;SNHG1 0.57 6.33 0.36 1.05e-9 Gut microbiome composition (summer); CESC cis rs4660306 1.000 rs882803 chr1:45976147 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.51 -6.61 -0.38 2.04e-10 Homocysteine levels; CESC cis rs55883249 0.957 rs62119432 chr2:9753939 C/T cg23886495 chr2:9695866 ADAM17 0.66 5.94 0.34 9.11e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC trans rs61931739 1.000 rs11052967 chr12:34020030 T/G cg26384229 chr12:38710491 ALG10B -0.46 -6.29 -0.36 1.3e-9 Morning vs. evening chronotype; CESC cis rs959260 1.000 rs6501786 chr17:73378775 A/T cg12999837 chr17:73267436 MIF4GD 0.45 5.32 0.31 2.18e-7 Systemic lupus erythematosus; CESC cis rs11098499 0.954 rs10031483 chr4:120422636 T/C cg24375607 chr4:120327624 NA 0.46 5.66 0.33 3.87e-8 Corneal astigmatism; CESC cis rs11227306 0.934 rs2234458 chr11:65639374 C/T cg00576331 chr11:65640516 EFEMP2 0.44 5.8 0.34 1.85e-8 DNA methylation (variation); CESC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg07701084 chr6:150067640 NUP43 0.4 5.48 0.32 9.87e-8 Lung cancer; CESC cis rs9929218 1.000 rs9928847 chr16:68797893 C/T cg02972257 chr16:68554789 NA 0.44 5.33 0.31 2.08e-7 Colorectal cancer; CESC trans rs2030746 0.899 rs11686154 chr2:121310937 G/A cg15455772 chr8:33269701 FUT10 0.43 6.09 0.35 3.86e-9 LDL cholesterol;Total cholesterol levels;LDL cholesterol levels; CESC cis rs6748734 1.000 rs6724662 chr2:241831560 A/G cg15164180 chr2:241846931 NA -0.35 -5.03 -0.3 9.01e-7 Urinary metabolites; CESC cis rs10857712 0.784 rs2265639 chr10:135221576 C/G cg01444801 chr10:135216882 MTG1 0.47 5.66 0.33 3.99e-8 Systemic lupus erythematosus; CESC cis rs3820068 0.603 rs6668726 chr1:15962614 G/A cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.3100000000000001e-10 Systolic blood pressure; CESC cis rs1008375 1.000 rs1121090 chr4:17676437 C/G cg02297831 chr4:17616191 MED28 0.45 5.64 0.33 4.42e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg05564831 chr3:52568323 NT5DC2 0.47 7.53 0.42 7.94e-13 Bipolar disorder; CESC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg04414720 chr1:150670196 GOLPH3L 0.57 7.94 0.44 5.86e-14 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21165122 chr7:149321434 ZNF767 0.61 7.12 0.4 1.03e-11 Gut microbiome composition (summer); CESC cis rs7116495 0.609 rs1894004 chr11:71759817 G/A cg07596299 chr11:71824057 C11orf51 -0.88 -5.65 -0.33 4.21e-8 Severe influenza A (H1N1) infection; CESC cis rs6088580 0.505 rs6058106 chr20:33278255 T/C cg24642439 chr20:33292090 TP53INP2 -0.43 -5.12 -0.3 6e-7 Glomerular filtration rate (creatinine); CESC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg16405210 chr4:1374714 KIAA1530 -0.97 -12.84 -0.62 1.19e-29 Longevity; CESC cis rs2832191 0.791 rs57721945 chr21:30498744 T/C cg24692254 chr21:30365293 RNF160 -0.79 -12.11 -0.6 3.71e-27 Dental caries; CESC cis rs57221529 0.766 rs72703065 chr5:588123 C/A cg16447950 chr5:562315 NA -0.62 -6.52 -0.37 3.51e-10 Lung disease severity in cystic fibrosis; CESC cis rs6905628 1 rs6905628 chr6:90344869 C/G cg23505970 chr6:90529759 MDN1 0.56 7.23 0.41 5.22e-12 Coronary artery disease; CESC cis rs17826219 0.706 rs61643715 chr17:29057762 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Body mass index; CESC trans rs3942852 0.774 rs2270990 chr11:48184983 G/T cg03929089 chr4:120376271 NA -0.66 -7.24 -0.41 4.83e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs67311347 1.000 rs977652 chr3:40479169 A/G cg24209194 chr3:40518798 ZNF619 0.49 6.51 0.37 3.81e-10 Renal cell carcinoma; CESC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg02807482 chr3:125708958 NA -0.42 -5.62 -0.33 4.74e-8 Blood pressure (smoking interaction); CESC cis rs7605827 0.964 rs10929367 chr2:15564718 T/C cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.45e-9 Educational attainment (years of education); CESC cis rs735396 1.000 rs2259852 chr12:121434833 G/A cg02403541 chr12:121454288 C12orf43 0.63 9.13 0.49 1.82e-17 N-glycan levels; CESC cis rs9473147 0.543 rs4711880 chr6:47480676 A/G cg20196966 chr6:47445060 CD2AP 0.41 5.33 0.31 2.13e-7 Platelet distribution width;Mean platelet volume; CESC cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg20503657 chr10:835505 NA 0.76 7.6 0.42 5.02e-13 Eosinophil percentage of granulocytes; CESC cis rs7580658 0.857 rs11890187 chr2:128083738 T/C cg10021288 chr2:128175891 PROC -0.41 -6.48 -0.37 4.43e-10 Protein C levels; CESC cis rs7843479 0.601 rs4872207 chr8:21842751 C/G cg17168535 chr8:21777572 XPO7 -0.69 -10.17 -0.53 9.97e-21 Mean corpuscular volume; CESC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.69 -8.25 -0.45 7.49e-15 LDL cholesterol;Cholesterol, total; CESC cis rs11078597 0.731 rs1317708 chr17:1639965 G/A cg18436246 chr17:1640651 WDR81 0.62 7.54 0.42 7.44e-13 Serum albumin level; CESC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs11098499 0.866 rs10518329 chr4:120401835 A/G cg24375607 chr4:120327624 NA 0.4 5.23 0.31 3.41e-7 Corneal astigmatism; CESC cis rs7071206 0.947 rs4979902 chr10:79399946 C/T cg23888215 chr10:79422304 NA 0.57 6.26 0.36 1.57e-9 Bone mineral density; CESC cis rs847577 0.677 rs1495525 chr7:97826232 G/A cg24562669 chr7:97807699 LMTK2 -0.58 -8.6 -0.47 7.16e-16 Breast cancer; CESC cis rs950027 0.596 rs2467865 chr15:45638307 T/C cg21132104 chr15:45694354 SPATA5L1 0.67 8.55 0.46 1.01e-15 Response to fenofibrate (adiponectin levels); CESC cis rs2274273 1.000 rs4644 chr14:55604935 C/A cg04306507 chr14:55594613 LGALS3 0.28 5.19 0.3 4.11e-7 Protein biomarker; CESC cis rs6547741 0.967 rs4665986 chr2:27755168 G/A cg21248554 chr2:27665150 KRTCAP3 0.25 5.09 0.3 6.82e-7 Oral cavity cancer; CESC cis rs151234 0.676 rs508022 chr16:28573963 C/T cg01378222 chr16:28622494 SULT1A1 -0.56 -7.12 -0.4 1e-11 Platelet distribution width; CESC cis rs9325144 0.671 rs7485963 chr12:38768254 C/G cg26384229 chr12:38710491 ALG10B -0.56 -7.9 -0.44 7.48e-14 Morning vs. evening chronotype; CESC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg25405998 chr7:65216604 CCT6P1 0.46 5.2 0.3 4.02e-7 Aortic root size; CESC cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg20503657 chr10:835505 NA 0.7 7.87 0.44 9.02e-14 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.753 rs11932536 chr4:98930105 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs75804782 0.581 rs3191996 chr2:239344412 A/G cg18131467 chr2:239335373 ASB1 0.66 5.44 0.32 1.23e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.67 6.97 0.39 2.47e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8014204 0.570 rs7147721 chr14:75186010 A/G cg11812906 chr14:75593930 NEK9 0.42 5.14 0.3 5.46e-7 Caffeine consumption; CESC cis rs3733585 0.673 rs9993410 chr4:9951264 C/T cg00071950 chr4:10020882 SLC2A9 -0.7 -11.41 -0.57 8.64e-25 Cleft plate (environmental tobacco smoke interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06972998 chr10:76585851 MYST4 -0.45 -6.15 -0.35 2.86e-9 Gut microbiota (bacterial taxa); CESC cis rs2952156 0.920 rs12150298 chr17:37834541 T/C cg07936489 chr17:37558343 FBXL20 -0.58 -7.68 -0.43 3.12e-13 Asthma; CESC cis rs4253772 0.637 rs8135997 chr22:46651366 G/A cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.48 5.11 0.3 6.16e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4594175 0.926 rs12432356 chr14:51631223 T/G cg23942311 chr14:51606299 NA 0.41 6.22 0.36 1.95e-9 Cancer; CESC cis rs3008870 1.000 rs58680688 chr1:67443751 C/G cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -14.14 -0.66 3.43e-34 Lymphocyte percentage of white cells; CESC cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg17366294 chr4:99064904 C4orf37 0.57 7.94 0.44 5.7e-14 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg05340658 chr4:99064831 C4orf37 0.83 13.12 0.63 1.19e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7249142 0.549 rs539 chr19:19287802 A/G cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.29 5.21 0.3 3.76e-7 IgG glycosylation; CESC cis rs473651 0.935 rs541013 chr2:239336492 G/A cg18131467 chr2:239335373 ASB1 1.06 21.61 0.8 2.13e-60 Multiple system atrophy; CESC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg05025164 chr4:1340916 KIAA1530 0.92 12.39 0.61 4.22e-28 Longevity; CESC trans rs4906172 1.000 rs4906172 chr14:102454933 C/A cg17920195 chr4:129149383 NA 0.31 6.1 0.35 3.81e-9 Menopause (age at onset); CESC cis rs7818345 1.000 rs7818345 chr8:19306618 T/C cg11303988 chr8:19266685 CSGALNACT1 0.36 6.38 0.37 7.66e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs6424115 1.000 rs4237 chr1:24114129 C/T cg10978503 chr1:24200527 CNR2 0.27 5.37 0.31 1.7e-7 Immature fraction of reticulocytes; CESC cis rs10465746 0.573 rs12121175 chr1:84468961 T/G cg10977910 chr1:84465055 TTLL7 0.44 5.58 0.32 5.93e-8 Obesity-related traits; CESC cis rs11122272 0.735 rs2474633 chr1:231486989 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -6.38 -0.36 7.95e-10 Hemoglobin concentration; CESC cis rs10392 0.500 rs8118646 chr20:37600887 A/G cg27552599 chr20:37590471 DHX35 0.37 5.48 0.32 9.82e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs593982 1.000 rs56257941 chr11:65505641 C/T cg08755490 chr11:65554678 OVOL1 -1.26 -10.56 -0.54 5.65e-22 Atopic dermatitis; CESC cis rs4927850 0.709 rs6783079 chr3:195652708 T/C cg00031303 chr3:195681400 NA 0.76 9.54 0.51 9.8e-19 Pancreatic cancer; CESC cis rs67460515 0.531 rs1585483 chr3:160843111 G/A cg03342759 chr3:160939853 NMD3 -0.52 -6.55 -0.37 2.99e-10 Parkinson's disease; CESC trans rs9467711 0.659 rs13195509 chr6:26463660 C/T cg01620082 chr3:125678407 NA -0.78 -6.8 -0.39 6.73e-11 Autism spectrum disorder or schizophrenia; CESC cis rs7680126 0.633 rs11728093 chr4:10296407 A/C cg00071950 chr4:10020882 SLC2A9 -0.54 -6.08 -0.35 4.12e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg08736216 chr1:53307985 ZYG11A -0.37 -6.14 -0.35 2.98e-9 Monocyte count; CESC cis rs854765 0.647 rs7406744 chr17:17981938 C/G cg16928487 chr17:17741425 SREBF1 -0.53 -8.74 -0.47 2.72e-16 Total body bone mineral density; CESC cis rs72781680 0.611 rs72797824 chr2:24356456 T/G cg08917208 chr2:24149416 ATAD2B 0.57 5.57 0.32 6.1e-8 Lymphocyte counts; CESC cis rs4664304 0.934 rs72957586 chr2:160762687 G/A cg03641300 chr2:160917029 PLA2R1 -0.48 -6.78 -0.38 8.02e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg24879335 chr3:133465180 TF 0.45 8.41 0.46 2.63e-15 Iron status biomarkers (transferrin levels); CESC cis rs3008870 0.585 rs2815382 chr1:67515228 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.46 5.74 0.33 2.61e-8 Lymphocyte percentage of white cells; CESC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.61 0.33 5.17e-8 Menopause (age at onset); CESC trans rs931812 0.825 rs35472498 chr8:101894167 G/A cg20993868 chr7:22813445 NA 0.54 7.46 0.42 1.26e-12 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg05564831 chr3:52568323 NT5DC2 -0.47 -7.43 -0.42 1.49e-12 Bipolar disorder; CESC cis rs6831352 0.918 rs17218141 chr4:100055908 T/C cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg18876405 chr7:65276391 NA -0.71 -10.0 -0.52 3.48e-20 Corneal structure; CESC cis rs6831352 0.879 rs17218003 chr4:100054723 G/C cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs12458462 0.851 rs3859317 chr18:77443093 A/C cg23301140 chr18:77439876 CTDP1 0.55 7.41 0.41 1.72e-12 Monocyte count; CESC cis rs1018836 0.544 rs2063978 chr8:91459525 C/T cg16814680 chr8:91681699 NA -0.45 -6.0 -0.35 6.43e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2204008 0.641 rs2387810 chr12:38368875 G/T cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.77e-9 Bladder cancer; CESC cis rs4253772 0.591 rs11703848 chr22:46685131 A/G cg18190219 chr22:46762943 CELSR1 -0.59 -5.46 -0.32 1.09e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7551222 0.721 rs4252717 chr1:204512100 T/C cg20240347 chr1:204465584 NA -0.28 -5.74 -0.33 2.59e-8 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22094205 chr11:74109076 PGM2L1 -0.44 -6.05 -0.35 4.85e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01419670 chr5:115696151 NA 0.43 6.19 0.36 2.29e-9 Gut microbiota (bacterial taxa); CESC cis rs2228479 1.000 rs12596492 chr16:89957169 T/G cg14709524 chr16:89940631 TCF25 0.87 6.44 0.37 5.45e-10 Skin colour saturation; CESC cis rs7662987 0.517 rs2602873 chr4:100039032 G/C cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC cis rs2625529 0.689 rs12161990 chr15:72202440 T/C cg16672083 chr15:72433130 SENP8 0.42 6.15 0.35 2.78e-9 Red blood cell count; CESC cis rs7582720 0.832 rs114139737 chr2:203721733 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg00255919 chr5:131827918 IRF1 -0.34 -5.12 -0.3 5.78e-7 Breast cancer;Mosquito bite size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07153501 chr2:172864976 MAP1D 0.57 6.34 0.36 1.01e-9 Gut microbiome composition (summer); CESC cis rs12765878 1.000 rs11191849 chr10:105650880 T/A cg24587175 chr10:105670608 OBFC1 0.33 5.43 0.32 1.28e-7 Coronary artery disease; CESC trans rs9850225 0.665 rs6795503 chr3:80478208 A/T cg27138204 chr12:54446100 HOXC4 0.39 6.23 0.36 1.84e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs9291683 0.588 rs12507330 chr4:10002195 G/A cg02734326 chr4:10020555 SLC2A9 0.44 6.38 0.36 7.84e-10 Bone mineral density; CESC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg27297192 chr10:134578999 INPP5A 0.41 5.47 0.32 1.05e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg16545954 chr1:2118288 C1orf86 -0.32 -5.83 -0.34 1.61e-8 Height; CESC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg06456125 chr7:65229604 NA -0.39 -5.1 -0.3 6.54e-7 Aortic root size; CESC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg25036284 chr2:26402008 FAM59B -0.61 -6.98 -0.39 2.3e-11 Gut microbiome composition (summer); CESC cis rs2836633 0.894 rs55955614 chr21:40037330 T/G cg05519781 chr21:40033154 ERG 0.78 13.52 0.64 5.12e-32 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01487461 chr9:2017199 SMARCA2 0.46 6.04 0.35 5.08e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg04414720 chr1:150670196 GOLPH3L 0.62 8.8 0.48 1.76e-16 Tonsillectomy; CESC cis rs6088580 0.634 rs1205344 chr20:32918298 G/A cg08999081 chr20:33150536 PIGU -0.64 -11.04 -0.56 1.46e-23 Glomerular filtration rate (creatinine); CESC cis rs9323205 0.954 rs4898682 chr14:51639577 C/T cg23942311 chr14:51606299 NA -0.42 -5.75 -0.33 2.4e-8 Cancer; CESC cis rs2769264 1.000 rs6684085 chr1:151357333 C/T cg18801370 chr1:151430492 POGZ -0.53 -7.01 -0.4 2.01e-11 Blood trace element (Cu levels); CESC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.9 0.39 3.79e-11 Bipolar disorder; CESC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg01341218 chr17:43662625 NA -0.55 -7.48 -0.42 1.12e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg05368731 chr17:41323189 NBR1 0.74 9.86 0.52 9.55e-20 Menopause (age at onset); CESC cis rs6120849 0.707 rs6120799 chr20:33614955 T/C cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg10053473 chr17:62856997 LRRC37A3 0.6 8.01 0.44 3.68e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3093024 0.595 rs4458654 chr6:167476068 A/C cg23791538 chr6:167370224 RNASET2 -0.52 -6.9 -0.39 3.81e-11 Rheumatoid arthritis; CESC cis rs9287719 0.967 rs6751398 chr2:10738972 T/C cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC trans rs7582180 0.700 rs1437971 chr2:100986964 A/C cg09773150 chr17:3796596 CAMKK1 0.65 6.41 0.37 6.6e-10 Intelligence (multi-trait analysis); CESC cis rs67311347 1.000 rs34762643 chr3:40475433 C/T cg01475735 chr3:40494733 NA -0.4 -5.08 -0.3 7.14e-7 Renal cell carcinoma; CESC cis rs2439831 0.681 rs484846 chr15:43600803 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.93 11.23 0.57 3.35e-24 Lung cancer in ever smokers; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg16089233 chr7:129461722 NA 0.41 6.02 0.35 5.82e-9 Thyroid stimulating hormone; CESC cis rs9486719 1.000 rs11152951 chr6:96894135 C/G cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg17971929 chr21:40555470 PSMG1 1.05 15.96 0.7 1.17e-40 Cognitive function; CESC cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg03213289 chr20:61660250 NA 0.43 6.97 0.39 2.55e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg12412775 chr1:25698385 RHCE -0.31 -5.63 -0.33 4.59e-8 Erythrocyte sedimentation rate; CESC cis rs478304 0.934 rs574483 chr11:65515277 A/G cg08755490 chr11:65554678 OVOL1 0.5 6.6 0.38 2.2e-10 Acne (severe); CESC cis rs6695640 0.854 rs2762889 chr1:17733147 A/C cg01904812 chr1:17746340 RCC2 0.35 5.17 0.3 4.64e-7 Mean platelet volume; CESC cis rs11122272 0.705 rs1416914 chr1:231533196 C/T cg06096015 chr1:231504339 EGLN1 0.41 5.81 0.34 1.74e-8 Hemoglobin concentration; CESC trans rs3885907 0.542 rs11147439 chr13:31325643 C/A cg22352122 chr11:453757 PTDSS2 -0.38 -6.05 -0.35 4.8e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU); CESC cis rs9611565 0.525 rs1883827 chr22:41703579 A/G cg03806693 chr22:41940476 POLR3H -0.73 -8.54 -0.46 1.06e-15 Vitiligo; CESC trans rs11264799 0.765 rs67070092 chr1:157622973 T/A cg22691776 chr3:15032403 NR2C2 0.34 6.22 0.36 1.93e-9 IgA nephropathy; CESC cis rs4835473 0.639 rs28674022 chr4:144887562 C/T cg25736465 chr4:144833511 NA 0.41 6.37 0.36 8.26e-10 Immature fraction of reticulocytes; CESC trans rs7618501 1.000 rs695238 chr3:49869158 A/C cg21659725 chr3:3221576 CRBN 0.84 13.68 0.64 1.39e-32 Intelligence (multi-trait analysis); CESC cis rs9768139 0.935 rs10949715 chr7:158117246 G/T cg24154853 chr7:158122151 PTPRN2 0.38 6.17 0.35 2.5e-9 Calcium levels; CESC cis rs9811920 0.638 rs1688782 chr3:99630527 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.54 -8.66 -0.47 4.74e-16 Axial length; CESC cis rs2439831 0.867 rs7170489 chr15:43636651 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.84 12.26 0.6 1.11e-27 Lung cancer in ever smokers; CESC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.37 0.31 1.72e-7 Cognitive function; CESC cis rs4268898 0.662 rs72793208 chr2:24510284 C/T cg20701182 chr2:24300061 SF3B14 0.63 6.86 0.39 4.75e-11 Asthma; CESC cis rs9399137 0.507 rs61738647 chr6:135282735 T/C cg24558204 chr6:135376177 HBS1L 0.7 9.47 0.5 1.6e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7772486 0.790 rs2253307 chr6:146196181 T/G cg23711669 chr6:146136114 FBXO30 1.01 15.47 0.69 6.84e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs113835537 0.529 rs11227511 chr11:66281244 A/C cg22134325 chr11:66188745 NPAS4 0.36 5.66 0.33 3.93e-8 Airway imaging phenotypes; CESC cis rs74181299 0.892 rs2540945 chr2:65289825 A/G cg05010058 chr2:65284262 CEP68 0.35 6.07 0.35 4.52e-9 Pulse pressure; CESC cis rs7769051 0.522 rs3736725 chr6:133095172 A/G cg07930552 chr6:133119739 C6orf192 0.82 7.54 0.42 7.55e-13 Type 2 diabetes nephropathy; CESC cis rs17431357 1.000 rs17584461 chr12:121004236 A/C cg25045489 chr12:120971538 RNF10 -0.92 -5.43 -0.32 1.27e-7 Insulin resistance/response; CESC cis rs6088590 0.561 rs6059932 chr20:33175466 C/T cg08999081 chr20:33150536 PIGU 0.7 12.43 0.61 3.03e-28 Coronary artery disease; CESC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg05872129 chr22:39784769 NA -0.73 -10.36 -0.54 2.43e-21 Intelligence (multi-trait analysis); CESC cis rs11677370 0.603 rs10198219 chr2:3854600 T/C cg17052675 chr2:3827356 NA -0.45 -5.7 -0.33 3.2e-8 Type 2 diabetes; CESC cis rs9660992 0.967 rs1172135 chr1:205247160 G/C cg21643547 chr1:205240462 TMCC2 -0.43 -6.37 -0.36 8.3e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs9487051 0.735 rs1260596 chr6:109519847 T/C cg01475377 chr6:109611718 NA -0.37 -5.55 -0.32 6.99e-8 Reticulocyte fraction of red cells; CESC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 6.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10887741 0.532 rs791885 chr10:89410546 A/T cg24243914 chr10:89418206 PAPSS2 0.33 5.52 0.32 8e-8 Exercise (leisure time); CESC cis rs2380220 0.872 rs67846436 chr6:95951521 G/T cg15832292 chr6:96025679 MANEA -0.64 -5.77 -0.33 2.17e-8 Behavioural disinhibition (generation interaction); CESC cis rs9768139 0.708 rs896782 chr7:158114115 G/A cg25566285 chr7:158114605 PTPRN2 0.54 9.06 0.49 2.86e-17 Calcium levels; CESC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg11301795 chr4:187892539 NA -0.77 -12.15 -0.6 2.73e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs78707713 0.560 rs61848397 chr10:71225584 C/A cg12610070 chr10:71211762 TSPAN15 -0.34 -7.07 -0.4 1.4e-11 Venous thromboembolism; CESC cis rs228437 0.913 rs11154779 chr6:134909194 T/C cg24504307 chr6:134963096 NA 0.51 5.89 0.34 1.16e-8 Melanoma; CESC cis rs10504229 0.679 rs1442125 chr8:58036258 A/C cg22535103 chr8:58192502 C8orf71 0.59 6.77 0.38 8.45e-11 Developmental language disorder (linguistic errors); CESC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg15664640 chr17:80829946 TBCD 0.62 9.28 0.5 6.35e-18 Breast cancer; CESC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg04526738 chr4:183727387 NA 0.72 6.98 0.39 2.31e-11 Pediatric autoimmune diseases; CESC cis rs35110281 0.508 rs2838351 chr21:45110784 A/G cg04455712 chr21:45112962 RRP1B 0.47 7.11 0.4 1.1e-11 Mean corpuscular volume; CESC cis rs2294693 0.945 rs10947944 chr6:41004657 T/C cg14418226 chr6:40996092 UNC5CL 0.53 6.26 0.36 1.54e-9 Gastric cancer;Non-cardia gastric cancer; CESC cis rs6424115 0.679 rs2076345 chr1:24083494 C/T cg15997130 chr1:24165203 NA -0.4 -5.08 -0.3 7.2e-7 Immature fraction of reticulocytes; CESC cis rs10857712 0.754 rs2297033 chr10:135234848 C/T cg22671611 chr10:135291010 NA -0.34 -5.09 -0.3 6.67e-7 Systemic lupus erythematosus; CESC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg00815214 chr21:47717953 NA 0.42 6.15 0.35 2.78e-9 Testicular germ cell tumor; CESC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16954204 chr6:20212978 MBOAT1 -0.73 -8.94 -0.48 7.03e-17 Gut microbiome composition (summer); CESC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg16743903 chr16:89593216 SPG7 -0.47 -6.03 -0.35 5.44e-9 Multiple myeloma (IgH translocation); CESC cis rs12677618 1.000 rs12677618 chr8:142302024 C/T cg27411547 chr8:142287226 NA -0.47 -5.69 -0.33 3.37e-8 Plateletcrit; CESC cis rs9287719 0.967 rs12467642 chr2:10761484 G/A cg00105475 chr2:10696890 NA 0.38 5.37 0.31 1.7e-7 Prostate cancer; CESC cis rs6540559 0.546 rs75308488 chr1:210030639 T/C cg21951975 chr1:209979733 IRF6 0.57 6.09 0.35 3.96e-9 Cleft lip with or without cleft palate; CESC cis rs12451471 0.500 rs8077056 chr17:78076006 C/T cg06718696 chr17:78121285 EIF4A3 0.8 9.28 0.5 6.39e-18 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs17376456 0.877 rs13169675 chr5:93331284 A/G cg21475434 chr5:93447410 FAM172A 0.8 6.77 0.38 8.23e-11 Diabetic retinopathy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08478283 chr1:117076803 CD58 0.46 6.17 0.35 2.6e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs950169 0.686 rs12906474 chr15:85109237 A/G cg17507749 chr15:85114479 UBE2QP1 0.55 6.15 0.35 2.9e-9 Schizophrenia; CESC cis rs8062405 0.824 rs62034324 chr16:28536762 T/C cg07382826 chr16:28625726 SULT1A1 0.31 5.05 0.3 8.32e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg12386194 chr3:101231763 SENP7 0.61 6.62 0.38 2.02e-10 Colonoscopy-negative controls vs population controls; CESC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg17372223 chr3:52568218 NT5DC2 0.44 6.59 0.38 2.35e-10 Intelligence (multi-trait analysis); CESC cis rs2274273 1.000 rs8011834 chr14:55625977 A/C cg04306507 chr14:55594613 LGALS3 0.31 6.1 0.35 3.79e-9 Protein biomarker; CESC cis rs2050392 0.624 rs303450 chr10:30725337 C/A cg02070205 chr10:30722105 MAP3K8 -0.45 -5.37 -0.31 1.73e-7 Inflammatory bowel disease; CESC cis rs763121 0.819 rs5757169 chr22:39003495 G/A cg21395723 chr22:39101663 GTPBP1 0.5 6.72 0.38 1.12e-10 Menopause (age at onset); CESC cis rs12477438 0.798 rs6759354 chr2:99632195 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -10.74 -0.55 1.4e-22 Chronic sinus infection; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19151263 chr18:48724096 MEX3C -0.49 -6.73 -0.38 1.05e-10 Asthma; CESC cis rs17001868 0.568 rs3788578 chr22:40742921 C/T cg07138101 chr22:40742427 ADSL 0.57 5.42 0.32 1.37e-7 Mammographic density (dense area); CESC cis rs1775715 0.870 rs1755080 chr10:32255195 G/A cg18675610 chr10:32216311 ARHGAP12 0.33 5.14 0.3 5.37e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs11098499 0.909 rs28571712 chr4:120375980 G/A cg24375607 chr4:120327624 NA 0.48 5.9 0.34 1.12e-8 Corneal astigmatism; CESC cis rs9948 0.655 rs2314399 chr2:97442390 G/A cg01990225 chr2:97406019 LMAN2L -1.0 -7.83 -0.43 1.21e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.26 -0.31 2.92e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7085104 0.700 rs10883785 chr10:104603588 A/G cg15744005 chr10:104629667 AS3MT -0.36 -5.59 -0.32 5.6e-8 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs6968419 0.788 rs4276607 chr7:115821608 G/T cg02561103 chr7:115862891 TES -0.39 -5.24 -0.31 3.31e-7 Intraocular pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18394496 chr11:62554881 TMEM179B 0.67 8.15 0.45 1.44e-14 Gut microbiome composition (summer); CESC cis rs9287719 0.601 rs1861300 chr2:10763961 A/G cg00105475 chr2:10696890 NA 0.37 5.03 0.3 9.03e-7 Prostate cancer; CESC cis rs7843479 0.965 rs11785657 chr8:21859485 G/A cg17168535 chr8:21777572 XPO7 0.48 6.58 0.37 2.51e-10 Mean corpuscular volume; CESC cis rs6543140 0.964 rs1035126 chr2:103019981 C/T cg04239558 chr2:103089729 SLC9A4 0.49 6.21 0.36 2e-9 Blood protein levels; CESC cis rs6662572 1.000 rs11585275 chr1:46095989 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 5.67 0.33 3.69e-8 Blood protein levels; CESC cis rs7917772 0.503 rs7904955 chr10:104367092 C/T cg22532475 chr10:104410764 TRIM8 -0.4 -6.63 -0.38 1.83e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg21770322 chr7:97807741 LMTK2 0.54 8.22 0.45 8.9e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs7592578 0.771 rs12053190 chr2:191383348 A/G cg10560079 chr2:191398806 TMEM194B -0.69 -6.12 -0.35 3.37e-9 Diastolic blood pressure; CESC cis rs6866344 0.561 rs55974982 chr5:178141421 G/A cg10224037 chr5:178157518 ZNF354A 0.74 8.73 0.47 2.99e-16 Neutrophil percentage of white cells; CESC trans rs9951602 0.512 rs9949512 chr18:76641845 T/C cg02800362 chr5:177631904 HNRNPAB 0.62 8.1 0.45 1.96e-14 Obesity-related traits; CESC cis rs9611565 0.921 rs2235846 chr22:41741042 G/C cg06481639 chr22:41940642 POLR3H -0.47 -5.44 -0.32 1.19e-7 Vitiligo; CESC cis rs8038465 0.874 rs11574488 chr15:73999379 T/A cg15420318 chr15:73925796 NPTN 0.4 5.63 0.33 4.52e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7264396 0.676 rs6060723 chr20:34549947 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.1 0.35 3.72e-9 Total cholesterol levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12126796 chr10:123687380 ATE1 -0.47 -6.15 -0.35 2.78e-9 Fibrinogen levels; CESC cis rs72634258 0.796 rs10746475 chr1:8168261 T/A cg00042356 chr1:8021962 PARK7 -0.48 -5.27 -0.31 2.88e-7 Inflammatory bowel disease; CESC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg00277769 chr7:97922759 BAIAP2L1 -0.31 -5.09 -0.3 6.92e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7618501 1.000 rs6446295 chr3:49809063 G/T cg24308560 chr3:49941425 MST1R -0.49 -6.74 -0.38 9.66e-11 Intelligence (multi-trait analysis); CESC cis rs9322193 0.962 rs9322206 chr6:149962617 T/C cg13206674 chr6:150067644 NUP43 0.4 5.64 0.33 4.45e-8 Lung cancer; CESC cis rs2282802 0.685 rs6893253 chr5:139661279 T/C cg26211634 chr5:139558579 C5orf32 0.51 7.42 0.41 1.55e-12 Intelligence (multi-trait analysis); CESC cis rs11098499 0.863 rs12508173 chr4:120318526 T/C cg09307838 chr4:120376055 NA 0.92 12.53 0.61 1.29e-28 Corneal astigmatism; CESC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.77 0.38 8.42e-11 Bipolar disorder; CESC cis rs9394931 1.000 rs9394931 chr6:42873245 C/T cg10862848 chr6:42927986 GNMT 0.25 5.88 0.34 1.2e-8 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CESC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.68 0.61 4e-29 Gut microbiome composition (summer); CESC cis rs16854884 0.526 rs7643341 chr3:143726980 C/T cg06585982 chr3:143692056 C3orf58 0.56 7.56 0.42 6.42e-13 Economic and political preferences (feminism/equality); CESC cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg00033643 chr7:134001901 SLC35B4 -0.42 -5.3 -0.31 2.43e-7 Mean platelet volume; CESC cis rs7772486 0.743 rs2092262 chr6:146037105 C/T cg23711669 chr6:146136114 FBXO30 -0.82 -12.04 -0.59 6.45e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg00106254 chr7:1943704 MAD1L1 -0.47 -6.0 -0.35 6.34e-9 Bipolar disorder and schizophrenia; CESC cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg14500267 chr11:67383377 NA 0.36 5.72 0.33 2.91e-8 Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01172785 chr16:50092553 NA 0.53 6.97 0.39 2.56e-11 Fibrinogen levels; CESC cis rs9902453 0.904 rs55866125 chr17:28312993 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 9.3 0.5 5.37e-18 Coffee consumption (cups per day); CESC cis rs7833986 0.501 rs72653941 chr8:56942247 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.24 0.41 4.87e-12 Height; CESC cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg02935154 chr7:12443704 VWDE -0.59 -6.17 -0.35 2.53e-9 Coronary artery disease; CESC cis rs61759167 1.000 rs11587518 chr1:3096925 T/A cg01961086 chr1:3086487 PRDM16 -0.34 -5.08 -0.3 6.97e-7 Motion sickness; CESC cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs60154123 0.764 rs1418257 chr1:210452846 G/A cg22029157 chr1:209979665 IRF6 0.49 5.6 0.33 5.33e-8 Coronary artery disease; CESC cis rs8180040 0.932 rs11711265 chr3:47558448 T/C cg27129171 chr3:47204927 SETD2 0.6 8.5 0.46 1.4e-15 Colorectal cancer; CESC cis rs763014 0.833 rs3743903 chr16:632736 T/C cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC cis rs7762018 1.000 rs60253563 chr6:170083019 T/C cg13891659 chr6:170190454 C6orf122;C6orf208 0.53 5.52 0.32 8.28e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs9549260 0.592 rs9315783 chr13:41289164 T/C cg21288729 chr13:41239152 FOXO1 0.58 7.04 0.4 1.63e-11 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20181420 chr10:60028918 CISD1;IPMK 0.49 6.12 0.35 3.32e-9 Gut microbiome composition (summer); CESC cis rs35306767 0.903 rs765867 chr10:869901 G/T cg10556349 chr10:835070 NA 0.6 5.71 0.33 3.1e-8 Eosinophil percentage of granulocytes; CESC cis rs7044106 0.791 rs10984995 chr9:123479210 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.94 0.34 8.83e-9 Hip circumference adjusted for BMI; CESC cis rs17376456 0.825 rs10058331 chr5:93279115 T/G cg21475434 chr5:93447410 FAM172A 0.81 6.44 0.37 5.45e-10 Diabetic retinopathy; CESC cis rs6460942 0.591 rs7804805 chr7:12332066 C/G cg06484146 chr7:12443880 VWDE -0.66 -7.27 -0.41 4.01e-12 Coronary artery disease; CESC cis rs698833 0.852 rs698768 chr2:44576549 C/T cg04920474 chr2:44395004 PPM1B 0.36 5.06 0.3 7.96e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.42 -0.32 1.31e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7590368 0.673 rs56147885 chr2:10937095 T/A cg15705551 chr2:10952987 PDIA6 0.54 5.17 0.3 4.51e-7 Educational attainment (years of education); CESC cis rs791888 0.688 rs1980649 chr10:89422375 T/C cg13926569 chr10:89418898 PAPSS2 0.52 7.22 0.41 5.67e-12 Magnesium levels; CESC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg05340658 chr4:99064831 C4orf37 0.85 12.97 0.62 4.01e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.68 0.38 1.41e-10 Bipolar disorder; CESC cis rs950776 0.518 rs4887062 chr15:78837801 G/A cg24631222 chr15:78858424 CHRNA5 0.41 5.2 0.3 3.98e-7 Sudden cardiac arrest; CESC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg24531977 chr5:56204891 C5orf35 -0.88 -10.96 -0.56 2.74e-23 Initial pursuit acceleration; CESC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs7044106 0.762 rs1547268 chr9:123408688 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 11.04 0.56 1.44e-23 Hip circumference adjusted for BMI; CESC cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.69 0.33 3.44e-8 Hip circumference adjusted for BMI; CESC cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg21573476 chr21:45109991 RRP1B -0.48 -6.78 -0.38 7.96e-11 Mean corpuscular volume; CESC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg06634786 chr22:41940651 POLR3H 0.62 6.81 0.39 6.63e-11 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23411981 chr14:105940377 CRIP2 -0.54 -6.24 -0.36 1.75e-9 Gut microbiome composition (summer); CESC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg27266060 chr8:22091797 NA 0.37 7.36 0.41 2.33e-12 Hypertriglyceridemia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14654587 chr19:1880126 FAM108A1 -0.51 -6.87 -0.39 4.63e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg04944784 chr2:26401820 FAM59B 0.85 9.2 0.49 1.14e-17 Gut microbiome composition (summer); CESC cis rs4975709 0.838 rs4975752 chr5:1880588 A/C cg15595755 chr5:1867978 NA 0.47 7.43 0.42 1.5e-12 Cardiovascular disease risk factors; CESC cis rs2985684 0.841 rs12894785 chr14:50049755 G/C cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.44 -5.28 -0.31 2.63e-7 Carotid intima media thickness; CESC cis rs73001065 0.636 rs56241616 chr19:19506092 C/T cg03709012 chr19:19516395 GATAD2A 0.93 7.68 0.43 3.03e-13 LDL cholesterol; CESC cis rs6570726 0.905 rs388728 chr6:145816419 T/C cg23711669 chr6:146136114 FBXO30 0.82 12.29 0.6 8.74e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7635838 0.751 rs9811658 chr3:11395833 A/G cg00170343 chr3:11313890 ATG7 0.47 6.56 0.37 2.88e-10 HDL cholesterol; CESC cis rs854765 0.647 rs6826 chr17:18011140 C/T cg16928487 chr17:17741425 SREBF1 -0.54 -8.7 -0.47 3.67e-16 Total body bone mineral density; CESC cis rs6842047 1.000 rs6842047 chr4:187133576 A/C cg09526685 chr4:187126073 CYP4V2 0.6 5.3 0.31 2.43e-7 Blood protein levels; CESC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.1 0.4 1.14e-11 Tonsillectomy; CESC cis rs2980439 0.818 rs2945249 chr8:8094726 G/A cg08975724 chr8:8085496 FLJ10661 0.42 5.07 0.3 7.59e-7 Neuroticism; CESC cis rs561341 1.000 rs501312 chr17:30329066 A/G cg19193384 chr17:30244184 NA -0.7 -6.62 -0.38 2e-10 Hip circumference adjusted for BMI; CESC cis rs6500395 0.962 rs868792 chr16:48640632 T/C cg04672837 chr16:48644449 N4BP1 0.51 6.21 0.36 2.08e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2228479 0.850 rs12596934 chr16:89841605 T/G cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs80282103 0.618 rs74117849 chr10:1165425 A/G cg08668510 chr10:1095578 IDI1 0.74 5.92 0.34 9.9e-9 Glomerular filtration rate (creatinine); CESC cis rs472402 0.580 rs10076470 chr5:6632875 G/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.52 -6.83 -0.39 5.74e-11 Response to amphetamines; CESC cis rs10883723 0.962 rs1056738 chr10:104236481 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -5.67 -0.33 3.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs3820928 0.839 rs13398103 chr2:227859693 T/G cg05526886 chr2:227700861 RHBDD1 -0.5 -5.91 -0.34 1.05e-8 Pulmonary function; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18510056 chr10:77163383 C10orf41 -0.45 -6.49 -0.37 4.19e-10 Gut microbiota (bacterial taxa); CESC cis rs1185460 0.967 rs1177563 chr11:118949083 C/T cg23280166 chr11:118938394 VPS11 0.56 7.86 0.43 9.86e-14 Coronary artery disease; CESC cis rs7264396 0.563 rs2425084 chr20:34301871 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.62 6.94 0.39 3.03e-11 Total cholesterol levels; CESC cis rs116095464 0.558 rs10057299 chr5:242135 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.63 -0.47 5.66e-16 Breast cancer; CESC cis rs7107174 1.000 rs2510046 chr11:77988817 T/C cg02023728 chr11:77925099 USP35 0.5 6.77 0.38 8.03e-11 Testicular germ cell tumor; CESC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.78 0.59 4.88e-26 Platelet count; CESC cis rs7119 0.717 rs16968835 chr15:77734261 G/A cg17802220 chr15:77601643 NA -0.5 -7.0 -0.39 2.12e-11 Type 2 diabetes; CESC cis rs6963495 0.818 rs118134111 chr7:105161229 A/C cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs7084402 0.967 rs1649049 chr10:60324095 G/A cg07615347 chr10:60278583 BICC1 0.6 9.48 0.5 1.54e-18 Refractive error; CESC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg18769074 chr3:133464867 TF 0.32 5.89 0.34 1.19e-8 Iron status biomarkers; CESC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 10.31 0.54 3.52e-21 Platelet count; CESC cis rs2404602 0.647 rs3812908 chr15:77176158 C/T cg23625390 chr15:77176239 SCAPER 0.44 6.23 0.36 1.87e-9 Blood metabolite levels; CESC cis rs7589728 1.000 rs11893832 chr2:88507537 G/C cg04511125 chr2:88470314 THNSL2 0.54 5.19 0.3 4.25e-7 Plasma clusterin levels; CESC cis rs644799 1.000 rs488246 chr11:95560473 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.27 0.66 1.19e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs17021463 0.643 rs17311521 chr4:95298060 A/G cg11021082 chr4:95130006 SMARCAD1 -0.5 -6.97 -0.39 2.46e-11 Testicular germ cell tumor; CESC trans rs9354352 0.935 rs9354354 chr6:66699333 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.7 -10.31 -0.54 3.42e-21 Initial pursuit acceleration in psychotic disorders; CESC cis rs8040855 0.627 rs4843019 chr15:85644459 G/T cg08123816 chr15:85640762 PDE8A 0.38 5.69 0.33 3.32e-8 Bulimia nervosa; CESC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.46e-17 Gut microbiome composition (summer); CESC cis rs6430585 0.528 rs3099429 chr2:136655582 T/A cg07169764 chr2:136633963 MCM6 1.11 15.14 0.68 9.79e-38 Corneal structure; CESC cis rs9287719 0.967 rs6432120 chr2:10753771 C/T cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg17372223 chr3:52568218 NT5DC2 0.42 6.44 0.37 5.71e-10 Bipolar disorder; CESC cis rs1355223 0.902 rs12802323 chr11:34747739 G/A cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.24 -0.36 1.76e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs854765 0.583 rs7214002 chr17:17852104 G/C cg09796270 chr17:17721594 SREBF1 0.41 5.64 0.33 4.34e-8 Total body bone mineral density; CESC cis rs2120019 1.000 rs34237279 chr15:75361121 A/G cg17294928 chr15:75287854 SCAMP5 -0.68 -7.51 -0.42 8.84e-13 Blood trace element (Zn levels); CESC cis rs11155671 0.530 rs6935829 chr6:150217811 C/T cg09699651 chr6:150184138 LRP11 0.54 7.49 0.42 1.05e-12 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17378273 chr11:45169082 PRDM11 -0.59 -7.01 -0.4 2.01e-11 Gut microbiome composition (summer); CESC cis rs1801251 1.000 rs2592113 chr2:233669553 C/T cg08000102 chr2:233561755 GIGYF2 0.66 9.59 0.51 6.85e-19 Coronary artery disease; CESC cis rs7824557 0.606 rs2736273 chr8:11199938 C/A cg21775007 chr8:11205619 TDH 0.53 7.77 0.43 1.68e-13 Retinal vascular caliber; CESC trans rs1814175 0.645 rs1851850 chr11:50012168 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -18.47 -0.75 1.54e-49 Height; CESC cis rs4237845 0.537 rs4237844 chr12:58267987 A/G cg00677455 chr12:58241039 CTDSP2 -0.77 -10.07 -0.53 2.05e-20 Intelligence (multi-trait analysis); CESC cis rs7914558 0.966 rs10748836 chr10:104693917 G/A cg15744005 chr10:104629667 AS3MT -0.35 -5.48 -0.32 9.76e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg13906792 chr15:75199810 C15orf17 -0.35 -5.21 -0.3 3.79e-7 Breast cancer; CESC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg13607699 chr17:42295918 UBTF 0.54 6.8 0.39 6.85e-11 Total body bone mineral density; CESC cis rs3087591 0.922 rs9892839 chr17:29618990 A/G cg24425628 chr17:29625626 OMG;NF1 -0.43 -5.53 -0.32 7.6e-8 Hip circumference; CESC cis rs9910055 0.530 rs2269907 chr17:42294215 G/A cg08499158 chr17:42289980 UBTF -0.41 -5.26 -0.31 3e-7 Total body bone mineral density; CESC cis rs74181299 0.750 rs2723067 chr2:65277951 A/G cg05010058 chr2:65284262 CEP68 0.3 5.03 0.3 8.87e-7 Pulse pressure; CESC cis rs2710642 0.777 rs2539987 chr2:63142864 A/G cg17519650 chr2:63277830 OTX1 0.54 7.04 0.4 1.66e-11 LDL cholesterol levels;LDL cholesterol; CESC cis rs7267979 0.873 rs7453 chr20:25207074 A/G cg08601574 chr20:25228251 PYGB 0.38 5.62 0.33 4.93e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7264396 0.563 rs2425071 chr20:34292961 A/C cg23207816 chr20:34252616 CPNE1;RBM12 -0.65 -7.04 -0.4 1.63e-11 Total cholesterol levels; CESC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg24531977 chr5:56204891 C5orf35 -0.83 -11.11 -0.56 8.79e-24 Initial pursuit acceleration; CESC cis rs3126085 0.935 rs12144058 chr1:152170216 C/T cg03465714 chr1:152285911 FLG -0.45 -5.53 -0.32 7.5e-8 Atopic dermatitis; CESC cis rs2070488 0.775 rs13072731 chr3:38533335 A/C cg24069376 chr3:38537580 EXOG 0.37 6.39 0.37 7.25e-10 Electrocardiographic conduction measures; CESC cis rs3857536 0.813 rs2040594 chr6:66943966 A/G cg07460842 chr6:66804631 NA -0.41 -5.22 -0.31 3.67e-7 Blood trace element (Cu levels); CESC cis rs4144743 0.941 rs7211563 chr17:45324061 T/C cg18085866 chr17:45331354 ITGB3 -0.66 -7.64 -0.43 3.87e-13 Body mass index; CESC trans rs5758511 0.773 rs62240997 chr22:42354567 T/G cg15080870 chr19:47770746 CCDC9 0.5 6.2 0.36 2.15e-9 Birth weight; CESC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.81 0.39 6.65e-11 Bipolar disorder; CESC cis rs4803468 1.000 rs4803465 chr19:41918158 A/G cg09537434 chr19:41945824 ATP5SL 1.01 18.34 0.75 4.71e-49 Height; CESC cis rs9309473 1.000 rs6546836 chr2:73677833 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -6.32 -0.36 1.07e-9 Metabolite levels; CESC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg02931644 chr1:25747376 RHCE -0.39 -6.56 -0.37 2.88e-10 Erythrocyte sedimentation rate; CESC cis rs9549367 0.789 rs9549361 chr13:113898329 C/T cg00898013 chr13:113819073 PROZ 0.51 6.86 0.39 4.78e-11 Platelet distribution width; CESC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg27535305 chr1:53392650 SCP2 -0.34 -5.55 -0.32 7.05e-8 Monocyte count; CESC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg13628971 chr7:2884303 GNA12 0.64 8.31 0.45 4.97e-15 Height; CESC cis rs11169225 0.724 rs7305290 chr12:50341465 A/G cg04450003 chr12:50355995 AQP5 0.46 6.21 0.36 1.98e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs3092073 0.669 rs11697323 chr20:44551579 C/T cg00981651 chr20:44574847 PCIF1 0.4 6.0 0.35 6.31e-9 Intelligence (multi-trait analysis); CESC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.29 0.5 5.98e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs7845219 0.525 rs3019175 chr8:95949013 G/A cg13393036 chr8:95962371 TP53INP1 -0.4 -7.42 -0.41 1.64e-12 Type 2 diabetes; CESC cis rs9715521 0.775 rs11723682 chr4:59851969 C/T cg11281224 chr4:60001000 NA -0.51 -6.73 -0.38 1.02e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs12142240 0.583 rs5013330 chr1:46815154 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.95 0.34 8.41e-9 Tonsillectomy; CESC cis rs472402 0.623 rs8192131 chr5:6636465 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.46 -6.12 -0.35 3.29e-9 Response to amphetamines; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20696752 chr17:42143797 LSM12 -0.45 -6.64 -0.38 1.8e-10 Gambling; CESC cis rs6736093 1.000 rs17779482 chr2:112665677 C/T cg12686935 chr2:112915763 FBLN7 -0.39 -5.1 -0.3 6.51e-7 Coronary artery disease; CESC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.18 0.4 6.94e-12 Electroencephalogram traits; CESC cis rs9916302 0.706 rs667193 chr17:37448835 T/C cg07936489 chr17:37558343 FBXL20 0.92 10.37 0.54 2.23e-21 Glomerular filtration rate (creatinine); CESC cis rs3780486 1.000 rs10813951 chr9:33128021 C/T cg13443165 chr9:33130375 B4GALT1 -0.42 -5.63 -0.33 4.47e-8 IgG glycosylation; CESC cis rs6496667 0.533 rs2074584 chr15:91009381 C/T cg10434728 chr15:90938212 IQGAP1 0.3 5.17 0.3 4.58e-7 Rheumatoid arthritis; CESC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.07 -19.75 -0.77 5.44e-54 Prudent dietary pattern; CESC cis rs684232 0.602 rs416662 chr17:535699 A/G cg15660573 chr17:549704 VPS53 -0.8 -11.72 -0.58 7.73e-26 Prostate cancer; CESC cis rs2463822 1.000 rs2463820 chr11:62112290 A/T cg06239285 chr11:62104954 ASRGL1 0.98 8.69 0.47 3.89e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs7124681 0.585 rs10838773 chr11:47834346 G/A cg18512352 chr11:47633146 NA 0.35 5.35 0.31 1.92e-7 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg16405210 chr4:1374714 KIAA1530 -0.54 -7.4 -0.41 1.85e-12 Longevity; CESC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg03806693 chr22:41940476 POLR3H 1.18 13.88 0.65 2.76e-33 Vitiligo; CESC cis rs6674176 0.593 rs6675620 chr1:44417630 C/T cg13606994 chr1:44402422 ARTN -0.36 -5.43 -0.32 1.29e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg24634471 chr8:143751801 JRK 0.44 5.31 0.31 2.3e-7 Urinary tract infection frequency; CESC cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.87 0.34 1.29e-8 Colorectal cancer; CESC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.37 -0.31 1.76e-7 Life satisfaction; CESC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg04414720 chr1:150670196 GOLPH3L -0.61 -8.67 -0.47 4.29e-16 Tonsillectomy; CESC cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg04166393 chr7:2884313 GNA12 0.39 5.15 0.3 5.11e-7 Height; CESC cis rs514406 0.893 rs1242315 chr1:53417181 A/G cg08859206 chr1:53392774 SCP2 -0.57 -7.35 -0.41 2.54e-12 Monocyte count; CESC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg10295955 chr4:187884368 NA -1.08 -22.82 -0.81 1.67e-64 Lobe attachment (rater-scored or self-reported); CESC cis rs6964587 1.000 rs417 chr7:91581121 C/A cg17063962 chr7:91808500 NA -0.57 -7.69 -0.43 2.84e-13 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26879945 chr16:57318890 PLLP 0.53 6.12 0.35 3.26e-9 Gut microbiome composition (summer); CESC cis rs11098499 0.663 rs28369503 chr4:120238925 G/A cg09307838 chr4:120376055 NA 0.78 10.39 0.54 1.94e-21 Corneal astigmatism; CESC cis rs4919694 1.000 rs10509760 chr10:104634107 A/G cg04362960 chr10:104952993 NT5C2 0.79 6.67 0.38 1.48e-10 Arsenic metabolism; CESC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg12564285 chr5:131593104 PDLIM4 0.39 5.86 0.34 1.4e-8 Breast cancer; CESC cis rs8044995 0.517 rs2863973 chr16:68409435 A/C cg26727032 chr16:67993705 SLC12A4 -0.55 -6.43 -0.37 5.93e-10 Schizophrenia; CESC cis rs4629180 0.586 rs1159902 chr2:102133641 G/A cg04415270 chr2:102091202 RFX8 -0.32 -5.36 -0.31 1.77e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs7267979 0.789 rs1983974 chr20:25530619 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.78 -14.62 -0.67 6.61e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs7824557 0.602 rs11781375 chr8:11204532 A/G cg21775007 chr8:11205619 TDH 0.58 8.98 0.48 5.08e-17 Retinal vascular caliber; CESC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -6.37 -0.36 8.51e-10 Total body bone mineral density; CESC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg17376030 chr22:41985996 PMM1 0.8 8.44 0.46 2.16e-15 Vitiligo; CESC cis rs9611519 0.780 rs9611542 chr22:41677317 C/T cg06481639 chr22:41940642 POLR3H -0.48 -5.27 -0.31 2.77e-7 Neuroticism; CESC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg26338869 chr17:61819248 STRADA 0.69 9.11 0.49 2.15e-17 Prudent dietary pattern; CESC cis rs2935183 1 rs2935183 chr17:45607572 T/G cg08085267 chr17:45401833 C17orf57 0.45 5.98 0.34 7.11e-9 Multiple sclerosis or amyotrophic lateral sclerosis; CESC cis rs910316 1.000 rs10873275 chr14:75531460 A/T cg08847533 chr14:75593920 NEK9 0.99 18.25 0.75 9.34e-49 Height; CESC cis rs727563 0.636 rs2413653 chr22:42106996 T/C cg03806693 chr22:41940476 POLR3H 1.15 13.6 0.64 2.54e-32 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00176896 chr8:1185355 NA -0.48 -6.26 -0.36 1.53e-9 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs45524643 chr16:89815824 G/A cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg15921436 chr17:44337874 NA 0.43 5.27 0.31 2.78e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg24531977 chr5:56204891 C5orf35 0.87 11.07 0.56 1.16e-23 Initial pursuit acceleration; CESC cis rs2108622 0.727 rs62107763 chr19:15982598 T/C cg13772218 chr19:15982569 NA 0.29 5.8 0.34 1.85e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg27494647 chr7:150038898 RARRES2 0.43 5.09 0.3 6.77e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg10494973 chr17:80897199 TBCD -0.47 -5.5 -0.32 9.06e-8 Breast cancer; CESC trans rs7980799 0.682 rs1447873 chr12:33615236 A/G cg26384229 chr12:38710491 ALG10B -0.55 -7.81 -0.43 1.32e-13 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg18196295 chr10:418757 DIP2C 0.52 7.0 0.4 2.07e-11 Psychosis in Alzheimer's disease; CESC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg12463550 chr7:65579703 CRCP -0.62 -7.69 -0.43 2.98e-13 Aortic root size; CESC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg15595755 chr5:1867978 NA 0.55 9.21 0.49 1.03e-17 Cardiovascular disease risk factors; CESC cis rs6032067 0.929 rs13043503 chr20:43805835 T/C cg10761708 chr20:43804764 PI3 0.53 6.33 0.36 1.04e-9 Blood protein levels; CESC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg21770322 chr7:97807741 LMTK2 0.58 8.64 0.47 5.26e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs9443189 1.000 rs1280048 chr6:76529583 C/T cg01950844 chr6:76311363 SENP6 0.64 6.66 0.38 1.61e-10 Prostate cancer; CESC cis rs9467773 0.620 rs9467810 chr6:26608261 A/C cg24633756 chr6:26577808 NA 0.38 5.76 0.33 2.28e-8 Intelligence (multi-trait analysis); CESC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs1322639 0.614 rs7751131 chr6:169578710 G/A cg04662567 chr6:169592167 NA -0.49 -5.11 -0.3 6.06e-7 Pulse pressure; CESC cis rs7560272 0.501 rs2272178 chr2:73977609 C/T cg20560298 chr2:73613845 ALMS1 0.45 6.06 0.35 4.78e-9 Schizophrenia; CESC cis rs9287719 0.967 rs4284804 chr2:10722124 C/T cg02196655 chr2:10830764 NOL10 -0.36 -5.57 -0.32 6.1e-8 Prostate cancer; CESC cis rs7336332 0.598 rs74183666 chr13:28007765 A/T cg22138327 chr13:27999177 GTF3A 0.64 5.92 0.34 9.69e-9 Weight; CESC cis rs3818285 0.655 rs623980 chr10:111646147 C/T cg00817464 chr10:111662876 XPNPEP1 -0.43 -6.69 -0.38 1.35e-10 Superior crus of antihelix expression; CESC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg24562669 chr7:97807699 LMTK2 -0.48 -7.04 -0.4 1.67e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs6866344 0.697 rs62392833 chr5:178135452 T/A cg03877680 chr5:178157825 ZNF354A 0.78 9.0 0.48 4.56e-17 Neutrophil percentage of white cells; CESC cis rs1878931 0.624 rs37810 chr16:3451881 C/T cg02880119 chr16:3481970 NA 0.45 5.53 0.32 7.84e-8 Body mass index (adult); CESC cis rs9815354 0.812 rs56183581 chr3:41848492 C/T cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs2797160 1.000 rs1739349 chr6:126014984 G/C cg05901451 chr6:126070800 HEY2 0.46 6.55 0.37 2.89e-10 Endometrial cancer; CESC cis rs7264396 0.635 rs6060710 chr20:34536055 A/G cg17201900 chr20:34330562 RBM39 0.5 5.25 0.31 3.16e-7 Total cholesterol levels; CESC cis rs4604732 0.631 rs60311891 chr1:247623127 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.64e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7927771 0.864 rs755555 chr11:47431966 C/T cg05585544 chr11:47624801 NA -0.49 -7.0 -0.4 2.05e-11 Subjective well-being; CESC cis rs2637266 0.783 rs846647 chr10:78515508 C/G cg18941641 chr10:78392320 NA 0.43 8.42 0.46 2.39e-15 Pulmonary function; CESC cis rs10416265 0.527 rs7508599 chr19:33546512 A/T cg27124370 chr19:33622961 WDR88 0.55 7.59 0.42 5.3e-13 Bone properties (heel); CESC cis rs3747547 0.892 rs74755693 chr9:37951859 A/G cg13774184 chr9:37916125 SHB -0.64 -5.47 -0.32 1.05e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs17401966 0.931 rs912961 chr1:10356848 A/G cg15208524 chr1:10270712 KIF1B 0.43 5.44 0.32 1.18e-7 Hepatocellular carcinoma; CESC cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg16339924 chr4:17578868 LAP3 0.59 7.3 0.41 3.41e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00409521 chr11:89956229 CHORDC1 0.56 6.34 0.36 9.99e-10 Gut microbiome composition (summer); CESC cis rs7107174 1.000 rs11237471 chr11:78082604 C/T cg02023728 chr11:77925099 USP35 0.38 5.21 0.31 3.73e-7 Testicular germ cell tumor; CESC cis rs11122272 0.735 rs2808611 chr1:231548480 A/G cg06096015 chr1:231504339 EGLN1 -0.42 -5.94 -0.34 8.93e-9 Hemoglobin concentration; CESC cis rs67311347 1.000 rs13095055 chr3:40505666 G/T cg01475735 chr3:40494733 NA 0.44 5.68 0.33 3.47e-8 Renal cell carcinoma; CESC cis rs4974559 0.739 rs59810282 chr4:1320968 A/G cg02980000 chr4:1222292 CTBP1 0.7 6.35 0.36 9.11e-10 Systolic blood pressure; CESC cis rs8062405 1.000 rs4788099 chr16:28855727 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2228479 0.850 rs57267516 chr16:89903552 G/A cg04013166 chr16:89971882 TCF25 0.66 5.52 0.32 8.21e-8 Skin colour saturation; CESC cis rs4589502 0.528 rs8039656 chr15:67208848 G/A cg12317470 chr15:67143691 NA -0.46 -5.53 -0.32 7.86e-8 Lung cancer (smoking interaction); CESC cis rs7769051 0.522 rs57176306 chr6:133142168 C/T cg07930552 chr6:133119739 C6orf192 0.9 6.45 0.37 5.19e-10 Type 2 diabetes nephropathy; CESC cis rs761746 0.960 rs4820979 chr22:31914399 A/G cg25791279 chr22:32026902 PISD -0.53 -6.1 -0.35 3.84e-9 Intelligence; CESC cis rs36051895 0.623 rs7859286 chr9:5260940 G/T cg02405213 chr9:5042618 JAK2 -0.52 -6.43 -0.37 5.85e-10 Pediatric autoimmune diseases; CESC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg17143192 chr8:8559678 CLDN23 0.43 5.37 0.31 1.75e-7 Mood instability; CESC cis rs11122272 0.735 rs10489610 chr1:231517765 C/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -9.18 -0.49 1.24e-17 Mean corpuscular volume; CESC cis rs769267 0.864 rs7245983 chr19:19657632 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.52 6.51 0.37 3.82e-10 Tonsillectomy; CESC cis rs1707322 0.691 rs12031182 chr1:46220999 C/T cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35110281 0.714 rs2282526 chr21:45080552 A/T cg01579765 chr21:45077557 HSF2BP -0.57 -9.45 -0.5 1.85e-18 Mean corpuscular volume; CESC cis rs4835473 0.864 rs5015761 chr4:144658944 A/C cg25736465 chr4:144833511 NA -0.33 -5.18 -0.3 4.3e-7 Immature fraction of reticulocytes; CESC cis rs12325245 0.536 rs71389028 chr16:58663260 G/A cg05725404 chr16:58534157 NDRG4 -0.63 -5.32 -0.31 2.21e-7 Schizophrenia; CESC cis rs992157 0.798 rs7557709 chr2:219167529 G/A cg00012203 chr2:219082015 ARPC2 0.77 10.3 0.53 3.82e-21 Colorectal cancer; CESC cis rs7589342 0.839 rs7589790 chr2:106433909 C/G cg16077055 chr2:106428750 NCK2 -0.5 -6.95 -0.39 2.86e-11 Addiction; CESC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs7520050 0.966 rs6680380 chr1:46300189 T/G cg24296786 chr1:45957014 TESK2 0.43 5.42 0.32 1.32e-7 Red blood cell count;Reticulocyte count; CESC cis rs4481887 0.927 rs4244185 chr1:248486913 A/G cg00666640 chr1:248458726 OR2T12 0.35 5.98 0.35 7.04e-9 Common traits (Other); CESC cis rs12477438 0.765 rs10181422 chr2:99558970 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -8.83 -0.48 1.43e-16 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04065065 chr9:35096250 PIGO 0.6 6.58 0.37 2.55e-10 Gut microbiome composition (summer); CESC cis rs78456975 1.000 rs72776252 chr2:1525599 G/A cg01028140 chr2:1542097 TPO -0.62 -5.88 -0.34 1.2e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs72781680 0.611 rs72783605 chr2:24287864 A/G cg20701182 chr2:24300061 SF3B14 0.93 10.61 0.55 3.77e-22 Lymphocyte counts; CESC cis rs763014 0.931 rs62030903 chr16:638323 T/A cg07256732 chr16:621771 PIGQ -0.32 -5.26 -0.31 3.03e-7 Height; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg08876899 chr1:35545196 ZMYM1 0.45 6.05 0.35 4.79e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs4474465 0.833 rs10899540 chr11:78245549 T/A cg27205649 chr11:78285834 NARS2 0.44 5.34 0.31 1.96e-7 Alzheimer's disease (survival time); CESC cis rs7116495 1.000 rs7949480 chr11:71697588 T/C cg10381502 chr11:71823885 C11orf51 -0.69 -5.75 -0.33 2.45e-8 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21056458 chr19:12817517 SNORD41;TNPO2 -0.62 -7.17 -0.4 7.7e-12 Gut microbiome composition (summer); CESC cis rs2204008 0.660 rs2320745 chr12:38239101 T/C cg26384229 chr12:38710491 ALG10B 0.66 9.15 0.49 1.52e-17 Bladder cancer; CESC cis rs636291 0.517 rs2781233 chr1:10529194 T/C cg20482658 chr1:10539492 PEX14 -0.29 -5.97 -0.34 7.76e-9 Prostate cancer; CESC cis rs7819412 0.775 rs2001329 chr8:10986859 C/T cg21775007 chr8:11205619 TDH -0.46 -6.61 -0.38 2.12e-10 Triglycerides; CESC cis rs3749237 0.595 rs4855839 chr3:49507847 G/A cg07636037 chr3:49044803 WDR6 0.64 9.17 0.49 1.34e-17 Resting heart rate; CESC cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg18538332 chr22:24372958 LOC391322 -0.68 -9.67 -0.51 3.97e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10504229 0.679 rs7840100 chr8:58036662 T/G cg22535103 chr8:58192502 C8orf71 -0.6 -6.79 -0.38 7.43e-11 Developmental language disorder (linguistic errors); CESC cis rs9287719 0.935 rs61424402 chr2:10758371 T/A cg02196655 chr2:10830764 NOL10 -0.37 -5.57 -0.32 6.22e-8 Prostate cancer; CESC cis rs453301 0.653 rs1562211 chr8:8902424 A/G cg15556689 chr8:8085844 FLJ10661 -0.53 -7.04 -0.4 1.64e-11 Joint mobility (Beighton score); CESC cis rs34172651 0.917 rs200529 chr16:24758502 T/C cg06028605 chr16:24865363 SLC5A11 -0.35 -5.49 -0.32 9.48e-8 Intelligence (multi-trait analysis); CESC trans rs13360092 1.000 rs10058621 chr5:50555169 T/C cg03200537 chr16:87022121 NA 0.69 6.01 0.35 6.12e-9 Verbal declarative memory; CESC cis rs6598955 0.670 rs3795688 chr1:26560481 C/A cg04990556 chr1:26633338 UBXN11 -0.79 -11.53 -0.58 3.46e-25 Obesity-related traits; CESC cis rs12478296 1.000 rs56292923 chr2:243039986 C/T cg06360820 chr2:242988706 NA -0.71 -8.08 -0.44 2.26e-14 Obesity-related traits; CESC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs910316 1.000 rs4903279 chr14:75546583 C/T cg11812906 chr14:75593930 NEK9 0.89 15.23 0.68 4.57e-38 Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18876457 chr1:160071037 NA -0.52 -7.24 -0.41 5.02e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg11764359 chr7:65958608 NA 0.89 13.89 0.65 2.56e-33 Aortic root size; CESC cis rs6088580 0.634 rs6088512 chr20:33095891 G/A cg06115741 chr20:33292138 TP53INP2 0.45 5.74 0.33 2.53e-8 Glomerular filtration rate (creatinine); CESC cis rs986417 1.000 rs1254303 chr14:60886301 A/G cg00859478 chr14:60978094 SIX6 -0.47 -5.18 -0.3 4.36e-7 Gut microbiota (bacterial taxa); CESC cis rs36051895 0.664 rs7857081 chr9:5096728 G/A cg02405213 chr9:5042618 JAK2 -0.54 -6.77 -0.38 8.31e-11 Pediatric autoimmune diseases; CESC cis rs12142240 0.621 rs13374968 chr1:46843908 T/G cg10495392 chr1:46806563 NSUN4 0.55 6.11 0.35 3.47e-9 Menopause (age at onset); CESC cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg10523679 chr1:76189770 ACADM 0.75 10.09 0.53 1.8e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg24308560 chr3:49941425 MST1R -0.59 -8.68 -0.47 4.06e-16 Intelligence (multi-trait analysis); CESC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg24101359 chr6:42928495 GNMT 0.55 8.05 0.44 2.83e-14 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7267979 0.789 rs4815429 chr20:25521611 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.78 -14.55 -0.67 1.24e-35 Liver enzyme levels (alkaline phosphatase); CESC trans rs66573146 0.831 rs56081162 chr4:6989718 C/T cg07817883 chr1:32538562 TMEM39B 1.09 6.98 0.39 2.4e-11 Granulocyte percentage of myeloid white cells; CESC cis rs7084402 0.967 rs12261597 chr10:60297662 T/C cg07615347 chr10:60278583 BICC1 -0.57 -8.56 -0.47 9.58e-16 Refractive error; CESC cis rs4629180 0.586 rs1509497 chr2:102138184 C/T cg04415270 chr2:102091202 RFX8 -0.3 -5.25 -0.31 3.19e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg10578991 chr7:12443926 VWDE -0.49 -5.5 -0.32 8.87e-8 Coronary artery disease; CESC cis rs7845219 0.525 rs6471501 chr8:95922491 A/G cg23172400 chr8:95962367 TP53INP1 -0.4 -7.41 -0.41 1.7e-12 Type 2 diabetes; CESC cis rs6938 0.618 rs2044157 chr15:75225808 G/C cg14664628 chr15:75095509 CSK -0.51 -6.6 -0.38 2.2e-10 Breast cancer; CESC cis rs2243480 1.000 rs2462569 chr7:65474846 C/T cg18252515 chr7:66147081 NA 1.1 10.76 0.55 1.23e-22 Diabetic kidney disease; CESC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.44e-17 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04688917 chr3:179040469 ZNF639 0.52 6.86 0.39 4.92e-11 Gut microbiota (bacterial taxa); CESC cis rs2860975 0.620 rs1891072 chr10:96804978 G/A cg09036531 chr10:96991505 NA -0.37 -5.29 -0.31 2.52e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs61931739 0.500 rs9669027 chr12:34583528 C/T cg23762105 chr12:34175262 ALG10 0.4 5.17 0.3 4.62e-7 Morning vs. evening chronotype; CESC cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg05340658 chr4:99064831 C4orf37 0.83 12.91 0.62 6.52e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6539267 0.847 rs12831519 chr12:106682917 A/G cg00173435 chr12:106696525 TCP11L2 0.66 6.51 0.37 3.69e-10 Tourette syndrome; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15055922 chr19:53193944 ZNF83 0.48 6.52 0.37 3.61e-10 Asthma; CESC cis rs1823874 0.581 rs12905599 chr15:100339938 C/T cg16400843 chr15:100339927 C15orf51 0.32 5.06 0.3 7.87e-7 IgG glycosylation; CESC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg12564285 chr5:131593104 PDLIM4 0.39 5.98 0.34 7.12e-9 Breast cancer; CESC cis rs1729951 0.575 rs16844325 chr3:136678161 C/G cg04103450 chr3:136751342 NA 0.39 5.17 0.3 4.59e-7 Neuroticism; CESC cis rs7602441 0.521 rs12052706 chr2:14765777 A/G cg06545361 chr2:14773388 FAM84A 0.66 6.47 0.37 4.66e-10 Visceral adipose tissue adjusted for BMI; CESC cis rs644799 0.526 rs534973 chr11:95633624 A/T cg03916912 chr11:95522834 CEP57;FAM76B 0.5 6.67 0.38 1.45e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs929596 0.517 rs1875263 chr2:234625622 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.55 -7.09 -0.4 1.24e-11 Total bilirubin levels in HIV-1 infection; CESC cis rs7621025 0.500 rs71630059 chr3:136581611 G/A cg15507776 chr3:136538369 TMEM22 -0.76 -8.65 -0.47 4.94e-16 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs2249625 0.967 rs2056756 chr6:72916638 G/A cg18830697 chr6:72922368 RIMS1 -0.45 -6.44 -0.37 5.67e-10 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs1018836 0.923 rs4734269 chr8:91635474 G/C cg16814680 chr8:91681699 NA -0.74 -10.61 -0.55 3.89e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg24503407 chr1:205819492 PM20D1 0.45 6.14 0.35 3.01e-9 Menarche (age at onset); CESC cis rs7772486 0.875 rs10457795 chr6:146415665 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.58 0.37 2.45e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg27170947 chr2:26402098 FAM59B -0.87 -9.89 -0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs6570723 chr6:146151230 A/T cg05347473 chr6:146136440 FBXO30 0.55 7.26 0.41 4.4e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg27086442 chr16:15149995 NTAN1 0.5 6.47 0.37 4.61e-10 Thyroid stimulating hormone; CESC cis rs6062302 0.548 rs4809310 chr20:62228745 G/A cg09650180 chr20:62225654 GMEB2 -0.82 -9.28 -0.5 6.11e-18 Glioblastoma; CESC cis rs7264396 0.561 rs2064725 chr20:34569142 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -7.14 -0.4 9e-12 Total cholesterol levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16092991 chr4:15004611 CPEB2 -0.47 -6.75 -0.38 9.55e-11 Gambling; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13196216 chr6:34231128 NA 0.54 7.33 0.41 2.83e-12 Fibrinogen levels; CESC cis rs2273669 0.667 rs2003315 chr6:109367169 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27274463 chr12:110338238 TCHP 0.59 6.92 0.39 3.41e-11 Gut microbiome composition (summer); CESC cis rs1371867 0.846 rs1788189 chr8:101249762 G/T cg06002616 chr8:101225028 SPAG1 0.33 5.3 0.31 2.43e-7 Atrioventricular conduction; CESC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.61 0.38 2.05e-10 Bipolar disorder; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg07035298 chr11:76168949 C11orf30 0.4 6.13 0.35 3.22e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2073300 0.609 rs79250740 chr20:23417165 G/A cg12062639 chr20:23401060 NAPB 1.04 8.1 0.45 1.97e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg24818145 chr4:99064322 C4orf37 0.37 5.32 0.31 2.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.524 rs11653098 chr17:29122501 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg26408565 chr15:76604113 ETFA -0.44 -6.39 -0.37 7.23e-10 Blood metabolite levels; CESC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.31 0.54 3.54e-21 Platelet count; CESC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg10494973 chr17:80897199 TBCD 0.52 5.87 0.34 1.3e-8 Breast cancer; CESC cis rs2070488 0.804 rs13094715 chr3:38504430 G/A cg24069376 chr3:38537580 EXOG 0.35 5.99 0.35 6.71e-9 Electrocardiographic conduction measures; CESC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg20243544 chr17:37824526 PNMT -0.45 -5.48 -0.32 9.91e-8 Glomerular filtration rate (creatinine); CESC cis rs7772486 0.875 rs6909827 chr6:146365738 A/G cg05347473 chr6:146136440 FBXO30 0.48 6.51 0.37 3.73e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7512552 0.724 rs7002 chr1:150445819 A/G cg15654264 chr1:150340011 RPRD2 0.4 5.23 0.31 3.5e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs9640161 0.830 rs6722 chr7:150068933 T/C cg27494647 chr7:150038898 RARRES2 0.35 5.28 0.31 2.76e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs9549367 0.789 rs9549715 chr13:113908240 G/C cg00898013 chr13:113819073 PROZ -0.56 -7.74 -0.43 2.08e-13 Platelet distribution width; CESC cis rs7799006 0.606 rs34262822 chr7:2304275 C/T cg12745145 chr7:2261452 MAD1L1 -0.35 -5.45 -0.32 1.16e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs477692 0.625 rs4751104 chr10:131405358 G/A cg24747557 chr10:131355152 MGMT 0.44 6.12 0.35 3.28e-9 Response to temozolomide; CESC cis rs9457247 0.663 rs9459845 chr6:167440501 C/G cg23791538 chr6:167370224 RNASET2 -0.57 -7.71 -0.43 2.6e-13 Crohn's disease; CESC trans rs61931739 0.929 rs7955240 chr12:34066388 G/A cg26384229 chr12:38710491 ALG10B -0.46 -6.6 -0.38 2.21e-10 Morning vs. evening chronotype; CESC cis rs8028182 0.577 rs28693593 chr15:75849776 A/C cg20655648 chr15:75932815 IMP3 0.49 6.04 0.35 5.32e-9 Sudden cardiac arrest; CESC cis rs75920871 0.502 rs10790166 chr11:116779499 A/G cg03020885 chr11:116643423 BUD13 0.47 5.55 0.32 7.08e-8 Subjective well-being; CESC cis rs1375194 0.558 rs13418410 chr2:33800899 C/A cg04131969 chr2:33951647 MYADML -0.51 -6.36 -0.36 8.87e-10 Response to antidepressants in depression; CESC cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg00825309 chr19:58991885 ZNF446 -0.57 -8.3 -0.45 5.3e-15 Uric acid clearance; CESC cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg06212747 chr3:49208901 KLHDC8B 0.68 7.95 0.44 5.47e-14 Menarche (age at onset); CESC cis rs9911578 0.967 rs8182277 chr17:57144367 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.4 5.09 0.3 6.83e-7 Intelligence (multi-trait analysis); CESC cis rs9303401 1.000 rs9904677 chr17:56873025 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.74 9.58 0.51 7.58e-19 Cognitive test performance; CESC cis rs4604732 0.589 rs78689516 chr1:247626274 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs3820928 0.874 rs3752895 chr2:227886773 A/G cg11843606 chr2:227700838 RHBDD1 -0.48 -6.33 -0.36 1.04e-9 Pulmonary function; CESC cis rs116095464 0.558 rs10060089 chr5:205565 G/A cg22496380 chr5:211416 CCDC127 -0.95 -10.05 -0.53 2.34e-20 Breast cancer; CESC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg08499158 chr17:42289980 UBTF 0.57 7.36 0.41 2.25e-12 Total body bone mineral density; CESC cis rs950776 0.593 rs481134 chr15:78877563 C/T cg06917634 chr15:78832804 PSMA4 0.61 8.33 0.46 4.49e-15 Sudden cardiac arrest; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26631144 chr8:30670260 PPP2CB 0.49 6.04 0.35 5.26e-9 Gut microbiome composition (summer); CESC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg10053473 chr17:62856997 LRRC37A3 -0.65 -9.03 -0.49 3.52e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9467711 0.606 rs71557334 chr6:26365913 G/T cg14345882 chr6:26364793 BTN3A2 0.6 6.17 0.35 2.57e-9 Autism spectrum disorder or schizophrenia; CESC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg02725872 chr8:58115012 NA -0.42 -5.72 -0.33 2.88e-8 Developmental language disorder (linguistic errors); CESC cis rs9322193 0.607 rs4869755 chr6:150207483 G/A cg01145232 chr6:150245071 RAET1G 0.5 6.24 0.36 1.75e-9 Lung cancer; CESC trans rs1728785 0.901 rs11865339 chr16:68565296 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg04414720 chr1:150670196 GOLPH3L 0.45 5.96 0.34 8.13e-9 Tonsillectomy; CESC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg13798912 chr7:905769 UNC84A -0.6 -6.07 -0.35 4.4e-9 Cerebrospinal P-tau181p levels; CESC cis rs8112211 1.000 rs12609247 chr19:38821697 C/T cg14299480 chr19:38876666 GGN -0.42 -5.63 -0.33 4.51e-8 Blood protein levels; CESC cis rs12545109 0.917 rs10098993 chr8:57323116 T/C cg09654669 chr8:57350985 NA -0.59 -6.93 -0.39 3.28e-11 Obesity-related traits; CESC cis rs7542091 0.666 rs7537070 chr1:210043565 A/G cg23283495 chr1:209979779 IRF6 0.35 5.8 0.34 1.84e-8 Monobrow; CESC trans rs55704346 0.534 rs28609470 chr4:25397054 G/A cg01822600 chr1:245751692 KIF26B 0.42 6.1 0.35 3.65e-9 Tonsillectomy; CESC cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1023500 0.505 rs134901 chr22:42683520 C/T cg05082376 chr22:42548792 NA -0.35 -5.13 -0.3 5.53e-7 Schizophrenia; CESC cis rs1801251 1.000 rs6724117 chr2:233593660 T/G cg25237894 chr2:233734115 C2orf82 0.45 7.79 0.43 1.53e-13 Coronary artery disease; CESC cis rs4974559 0.739 rs28412861 chr4:1320092 A/G cg02980000 chr4:1222292 CTBP1 0.76 6.74 0.38 9.88e-11 Systolic blood pressure; CESC cis rs116095464 0.558 rs28729548 chr5:229025 C/T cg22857025 chr5:266934 NA -1.28 -18.8 -0.76 1.06e-50 Breast cancer; CESC cis rs1912483 0.505 rs11079772 chr17:45393739 A/C cg08085267 chr17:45401833 C17orf57 0.6 7.31 0.41 3.13e-12 Coronary artery disease; CESC cis rs2637266 0.678 rs846626 chr10:78540372 T/G cg18941641 chr10:78392320 NA 0.4 7.74 0.43 2.04e-13 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19137606 chr10:38146164 ZNF248 -0.56 -6.66 -0.38 1.59e-10 Gut microbiome composition (summer); CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg05780616 chr12:96252764 SNRPF -0.53 -6.29 -0.36 1.33e-9 Gut microbiota (bacterial taxa); CESC cis rs116095464 1.000 rs55671190 chr5:287422 G/A cg10591111 chr5:226296 SDHA -0.7 -5.87 -0.34 1.29e-8 Breast cancer; CESC cis rs7914558 1.000 rs2275271 chr10:104814162 T/C cg08650961 chr10:104748594 CNNM2 0.31 5.19 0.3 4.18e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs17376456 0.569 rs6879620 chr5:93119893 G/A cg25358565 chr5:93447407 FAM172A -0.72 -7.72 -0.43 2.33e-13 Diabetic retinopathy; CESC cis rs28647808 0.881 rs4549850 chr9:136265239 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04843900 chr20:16710618 SNRPB2 0.64 7.04 0.4 1.67e-11 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.88 0.34 1.23e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07274194 chr6:43423442 DLK2 -0.38 -6.12 -0.35 3.36e-9 Gambling; CESC trans rs4662834 0.765 rs12616669 chr2:129489014 A/G cg12497543 chr10:97515377 ENTPD1 0.38 6.13 0.35 3.18e-9 Response to bleomycin (chromatid breaks); CESC cis rs2806561 0.734 rs1952527 chr1:23400969 T/C cg12483005 chr1:23474871 LUZP1 0.37 5.72 0.33 2.87e-8 Height; CESC cis rs13385 0.769 rs59443048 chr5:139602802 C/A cg26211634 chr5:139558579 C5orf32 0.47 5.08 0.3 6.98e-7 Atrial fibrillation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27138088 chr11:842605 TSPAN4;POLR2L 0.68 7.57 0.42 6.12e-13 Gut microbiome composition (summer); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg19494004 chr6:79788446 PHIP -0.51 -6.99 -0.39 2.22e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg03806693 chr22:41940476 POLR3H -1.08 -13.61 -0.64 2.32e-32 Vitiligo; CESC trans rs561341 0.709 rs11542477 chr17:30185892 A/G cg27661571 chr11:113659931 NA 0.65 6.16 0.35 2.73e-9 Hip circumference adjusted for BMI; CESC cis rs34779708 0.931 rs12773169 chr10:35366462 G/C cg03585969 chr10:35415529 CREM 0.75 9.92 0.52 6.26e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7674212 0.541 rs4699051 chr4:104114394 T/C cg16532752 chr4:104119610 CENPE -0.44 -6.0 -0.35 6.29e-9 Type 2 diabetes; CESC cis rs4908760 0.757 rs301807 chr1:8484823 A/G cg00120948 chr1:8484417 RERE -0.38 -6.02 -0.35 5.82e-9 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04571369 chr19:19749068 GMIP 0.46 6.35 0.36 9.44e-10 Fibrinogen levels; CESC cis rs7191700 0.712 rs7187741 chr16:11433103 C/G cg00044050 chr16:11439710 C16orf75 -0.41 -5.22 -0.31 3.67e-7 Multiple sclerosis; CESC cis rs3806843 0.766 rs702397 chr5:140050265 A/G cg26395211 chr5:140044315 WDR55 0.45 6.06 0.35 4.77e-9 Depressive symptoms (multi-trait analysis); CESC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.99 0.35 6.7e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.673 rs9912122 chr17:29140716 C/A cg04154034 chr17:28927549 LRRC37B2 0.55 5.24 0.31 3.25e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8060686 0.545 rs74629553 chr16:68176415 C/A cg26727032 chr16:67993705 SLC12A4 -0.5 -5.45 -0.32 1.16e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg09699651 chr6:150184138 LRP11 0.52 6.56 0.37 2.83e-10 Lung cancer; CESC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC cis rs4780401 0.728 rs7188511 chr16:11773743 G/T cg01061890 chr16:11836724 TXNDC11 -0.51 -6.82 -0.39 5.98e-11 Rheumatoid arthritis; CESC cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg09997546 chr11:8931473 C11orf17;ST5 -0.3 -5.07 -0.3 7.5e-7 Hemoglobin concentration; CESC cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg23422044 chr7:1970798 MAD1L1 -0.53 -5.71 -0.33 3.02e-8 Bipolar disorder; CESC cis rs9596863 0.898 rs9316668 chr13:54400431 C/T ch.13.53330881F chr13:54432880 NA 0.66 5.28 0.31 2.7e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg17971929 chr21:40555470 PSMG1 0.94 12.96 0.62 4.46e-30 Cognitive function; CESC cis rs6460942 1.000 rs79964328 chr7:12319392 A/C cg10578991 chr7:12443926 VWDE -0.61 -6.41 -0.37 6.66e-10 Coronary artery disease; CESC trans rs11039798 0.512 rs1988465 chr11:49011303 C/T cg15704280 chr7:45808275 SEPT13 0.65 6.57 0.37 2.63e-10 Axial length; CESC cis rs425277 0.917 rs78395918 chr1:2045876 G/A cg24578937 chr1:2090814 PRKCZ 0.55 9.07 0.49 2.75e-17 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23348582 chr14:82000250 SEL1L -0.47 -6.09 -0.35 4.05e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24425829 chr1:59250882 JUN 0.6 7.19 0.4 6.59e-12 Gut microbiome composition (summer); CESC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.35 5.74 0.33 2.65e-8 Personality dimensions; CESC cis rs710216 0.912 rs11537640 chr1:43424519 T/G cg03128534 chr1:43423976 SLC2A1 0.54 6.25 0.36 1.62e-9 Red cell distribution width; CESC cis rs2832077 0.527 rs2832116 chr21:30228368 C/A cg08807101 chr21:30365312 RNF160 -0.66 -8.57 -0.47 8.73e-16 Cognitive test performance; CESC cis rs2108622 1.000 rs2108622 chr19:15990431 C/T cg13772218 chr19:15982569 NA 0.38 6.98 0.39 2.37e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs1729951 0.575 rs361244 chr3:136697506 C/T cg03617693 chr3:136751559 NA 0.39 5.42 0.32 1.33e-7 Neuroticism; CESC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.92 10.13 0.53 1.38e-20 Mean platelet volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18538297 chr19:58892579 ZNF837 -0.39 -6.19 -0.36 2.29e-9 Gambling; CESC cis rs9596863 0.750 rs1971924 chr13:54432432 T/G ch.13.53330881F chr13:54432880 NA -0.63 -5.37 -0.31 1.74e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs2274273 1.000 rs7142704 chr14:55630603 C/A cg04306507 chr14:55594613 LGALS3 0.31 6.15 0.35 2.77e-9 Protein biomarker; CESC cis rs9359856 0.564 rs34766278 chr6:90397132 G/C cg13799429 chr6:90582589 CASP8AP2 -0.64 -6.19 -0.36 2.24e-9 Bipolar disorder; CESC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg26335602 chr6:28129616 ZNF389 0.44 5.61 0.33 5.19e-8 Parkinson's disease; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg05897255 chr7:149535402 ZNF862 -0.48 -6.47 -0.37 4.67e-10 Recombination measurement; CESC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg07153921 chr17:41440717 NA -0.38 -5.19 -0.3 4.11e-7 Menopause (age at onset); CESC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg04944784 chr2:26401820 FAM59B 0.87 9.59 0.51 6.83e-19 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01032946 chr16:30991033 SETD1A 0.54 6.88 0.39 4.21e-11 Fibrinogen levels; CESC cis rs2439831 1.000 rs2444032 chr15:43755346 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.87 10.12 0.53 1.44e-20 Lung cancer in ever smokers; CESC cis rs62064224 0.658 rs62065460 chr17:30715007 A/G cg12855166 chr17:30846586 MYO1D 0.4 5.17 0.3 4.62e-7 Schizophrenia; CESC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg18252515 chr7:66147081 NA -0.43 -5.59 -0.32 5.73e-8 Aortic root size; CESC cis rs9611565 0.559 rs5758397 chr22:42019251 C/T cg06634786 chr22:41940651 POLR3H 0.61 6.15 0.35 2.88e-9 Vitiligo; CESC cis rs873946 0.557 rs4880427 chr10:134591389 T/C cg27286337 chr10:134555280 INPP5A 0.68 7.66 0.43 3.54e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6066835 1.000 rs3817991 chr20:47296365 G/C cg18078177 chr20:47281410 PREX1 0.72 5.1 0.3 6.38e-7 Multiple myeloma; CESC cis rs10463316 0.817 rs13359941 chr5:150802118 C/T cg03212797 chr5:150827313 SLC36A1 -0.48 -6.2 -0.36 2.1e-9 Metabolite levels (Pyroglutamine); CESC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs7089973 0.668 rs10885622 chr10:116643844 C/T cg23260525 chr10:116636907 FAM160B1 0.35 6.05 0.35 4.97e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6964587 1.000 rs9691325 chr7:91731047 G/A cg17063962 chr7:91808500 NA 0.56 7.73 0.43 2.3e-13 Breast cancer; CESC cis rs703842 0.616 rs10877023 chr12:58224199 C/A cg04478727 chr12:58166393 METTL1;FAM119B 0.57 6.65 0.38 1.67e-10 Multiple sclerosis; CESC cis rs7944584 0.879 rs11039182 chr11:47346723 T/C cg20307385 chr11:47447363 PSMC3 0.7 8.18 0.45 1.21e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg07700843 chr1:2391317 NA -0.41 -6.94 -0.39 2.95e-11 Non-obstructive azoospermia; CESC cis rs12681288 0.578 rs56702775 chr8:968860 G/A cg15309053 chr8:964076 NA 0.55 9.18 0.49 1.24e-17 Schizophrenia; CESC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg10691866 chr7:65817282 TPST1 0.32 5.38 0.31 1.66e-7 Aortic root size; CESC cis rs9303401 0.659 rs66514313 chr17:56714057 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.13 0.63 1.12e-30 Cognitive test performance; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17859048 chr1:151170906 PIP5K1A 0.55 6.2 0.36 2.19e-9 Gut microbiome composition (summer); CESC cis rs644799 0.526 rs530914 chr11:95632156 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.52 6.85 0.39 5.24e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4979906 1.000 rs11002246 chr10:79446777 T/A cg07817648 chr10:79422355 NA -0.6 -6.39 -0.37 7.58e-10 Mortality in heart failure; CESC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.81 0.48 1.69e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs1562975 0.609 rs11932691 chr4:109431283 C/G cg16022748 chr4:109541635 LOC285456;RPL34 0.43 5.5 0.32 9.04e-8 Height; CESC cis rs28489187 0.706 rs72724606 chr1:85850246 T/C cg16011679 chr1:85725395 C1orf52 0.47 5.62 0.33 4.9e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs3820068 0.581 rs78175477 chr1:15948091 C/G cg13390004 chr1:15929781 NA 0.37 5.95 0.34 8.6e-9 Systolic blood pressure; CESC cis rs7647973 1.000 rs11928090 chr3:49604904 G/A cg02487422 chr3:49467188 NICN1 0.4 5.05 0.3 8.11e-7 Menarche (age at onset); CESC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg13393036 chr8:95962371 TP53INP1 -0.52 -11.41 -0.57 8.68e-25 Type 2 diabetes; CESC cis rs12313068 0.709 rs11829777 chr12:110503770 T/C cg12870014 chr12:110450643 ANKRD13A 0.83 9.29 0.5 5.79e-18 Intelligence (multi-trait analysis); CESC cis rs4595586 0.545 rs3858553 chr12:39381291 A/C cg13010199 chr12:38710504 ALG10B 0.44 5.51 0.32 8.37e-8 Morning vs. evening chronotype; CESC cis rs6088580 0.634 rs6058052 chr20:33047084 A/G cg06115741 chr20:33292138 TP53INP2 0.46 5.97 0.34 7.6e-9 Glomerular filtration rate (creatinine); CESC cis rs9467711 0.606 rs67509210 chr6:26354100 G/T cg14345882 chr6:26364793 BTN3A2 0.6 6.29 0.36 1.33e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2651899 0.902 rs1736522 chr1:3080940 C/G cg22674798 chr1:3096360 PRDM16 0.36 6.98 0.39 2.36e-11 Migraine; CESC cis rs738322 1.000 rs133009 chr22:38569653 G/C cg17652424 chr22:38574118 PLA2G6 -0.34 -6.03 -0.35 5.53e-9 Cutaneous nevi; CESC cis rs7123876 0.553 rs12099027 chr11:72433920 A/G cg04827223 chr11:72435913 ARAP1 -0.65 -11.51 -0.58 4.09e-25 Body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11993436 chr7:155437098 RBM33 -0.44 -7.03 -0.4 1.73e-11 Gambling; CESC cis rs79349575 0.783 rs4794000 chr17:47022755 C/G cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg07128330 chr12:2921958 ITFG2 0.46 6.56 0.37 2.8e-10 Positive affect; CESC cis rs7829975 0.511 rs1543238 chr8:8134809 A/G cg15556689 chr8:8085844 FLJ10661 0.54 6.4 0.37 6.89e-10 Mood instability; CESC cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg00475322 chr7:917719 C7orf20 0.46 6.8 0.39 6.86e-11 Perceived unattractiveness to mosquitoes; CESC cis rs763014 0.838 rs4984670 chr16:641044 A/G cg07343612 chr16:622815 PIGQ -0.5 -6.9 -0.39 3.76e-11 Height; CESC cis rs397969 0.569 rs62066351 chr17:19900994 A/G cg12073167 chr17:19770448 ULK2 -0.46 -5.28 -0.31 2.63e-7 Platelet count; CESC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg17372223 chr3:52568218 NT5DC2 0.43 6.11 0.35 3.61e-9 Bipolar disorder; CESC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg18876405 chr7:65276391 NA -0.53 -7.38 -0.41 2.09e-12 Aortic root size; CESC cis rs7546094 0.530 rs2999158 chr1:113239478 T/C cg22162597 chr1:113214053 CAPZA1 -0.39 -5.04 -0.3 8.59e-7 Platelet distribution width; CESC cis rs761746 0.846 rs2295251 chr22:32013265 C/T cg25791279 chr22:32026902 PISD -0.5 -5.79 -0.34 1.93e-8 Intelligence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10963511 chr15:25460583 SNORD115-15;SNORD115-21;SNORD115-25 -0.46 -6.07 -0.35 4.32e-9 Gut microbiome composition (summer); CESC cis rs9309473 0.607 rs2421488 chr2:73590625 C/T cg20560298 chr2:73613845 ALMS1 -0.44 -5.63 -0.33 4.52e-8 Metabolite levels; CESC cis rs7959452 1.000 rs2168029 chr12:69734641 A/C cg20891283 chr12:69753455 YEATS4 0.57 7.64 0.42 4.03e-13 Blood protein levels; CESC cis rs9300255 0.722 rs12322888 chr12:123825559 A/G cg19016782 chr12:123741754 C12orf65 -0.44 -6.17 -0.35 2.61e-9 Neutrophil percentage of white cells; CESC cis rs7264396 0.790 rs6121018 chr20:34249060 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.77 0.43 1.78e-13 Total cholesterol levels; CESC cis rs6456156 0.742 rs1331299 chr6:167533467 A/G cg07741184 chr6:167504864 NA 0.31 5.17 0.3 4.65e-7 Primary biliary cholangitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11522767 chr6:157342961 ARID1B 0.5 6.51 0.37 3.74e-10 Gut microbiota (bacterial taxa); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12947103 chr5:68392786 SLC30A5 -0.4 -6.45 -0.37 5.27e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs8017423 0.967 rs7155315 chr14:90700787 G/A cg14092571 chr14:90743983 NA -0.58 -8.43 -0.46 2.31e-15 Mortality in heart failure; CESC cis rs75477785 1.000 rs12069187 chr1:209985952 G/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC cis rs1983891 0.955 rs4714479 chr6:41518807 A/G cg20194872 chr6:41519635 FOXP4 0.54 7.74 0.43 2.14e-13 Prostate cancer; CESC cis rs6987853 0.931 rs2923399 chr8:42439509 G/A cg09913449 chr8:42400586 C8orf40 0.41 6.41 0.37 6.54e-10 Mean corpuscular hemoglobin concentration; CESC cis rs4720575 1.000 rs1859522 chr7:47096901 G/A cg00036614 chr7:47093842 NA -0.43 -6.74 -0.38 9.73e-11 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg00990874 chr7:1149470 C7orf50 -0.46 -5.07 -0.3 7.54e-7 Bronchopulmonary dysplasia; CESC cis rs72781680 0.846 rs72780108 chr2:23986780 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.26 0.36 1.51e-9 Cystic fibrosis severity; CESC cis rs258892 0.841 rs34665 chr5:72158396 T/C cg21869765 chr5:72125136 TNPO1 0.44 5.6 0.33 5.41e-8 Small cell lung carcinoma; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05703344 chr12:111051745 TCTN1 0.46 6.58 0.37 2.44e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs501120 1.000 rs559580 chr10:44752078 C/T cg09554077 chr10:44749378 NA -0.49 -6.1 -0.35 3.67e-9 Coronary artery disease;Coronary heart disease; CESC cis rs7250872 0.619 rs2396359 chr19:1819125 T/C cg10370574 chr19:1840461 REXO1 -0.44 -6.12 -0.35 3.42e-9 Bipolar disorder; CESC cis rs11098499 0.955 rs1397608 chr4:120161744 A/G cg09307838 chr4:120376055 NA 0.86 11.44 0.58 6.63e-25 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04402633 chr11:2907113 CDKN1C 0.59 6.94 0.39 3.02e-11 Gut microbiome composition (summer); CESC cis rs12973672 0.904 rs12974791 chr19:35767218 A/G cg12095397 chr19:35769544 USF2 0.54 7.33 0.41 2.81e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9291683 0.588 rs2240724 chr4:10021290 G/C cg02734326 chr4:10020555 SLC2A9 0.48 6.97 0.39 2.56e-11 Bone mineral density; CESC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg05863683 chr7:1912471 MAD1L1 -0.47 -7.48 -0.42 1.12e-12 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg03467027 chr4:99064603 C4orf37 0.42 5.3 0.31 2.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9583531 0.600 rs9521909 chr13:111362170 A/G cg15841412 chr13:111365552 ING1 0.52 6.74 0.38 1.01e-10 Coronary artery disease; CESC trans rs1814175 0.647 rs10769646 chr11:49992204 C/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs1790761 0.587 rs7934075 chr11:67295949 T/C cg14500267 chr11:67383377 NA -0.31 -5.15 -0.3 4.98e-7 Mean corpuscular volume; CESC cis rs9457247 0.508 rs9459874 chr6:167504127 A/G cg07741184 chr6:167504864 NA -0.32 -5.69 -0.33 3.37e-8 Crohn's disease; CESC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 -1.08 -11.79 -0.59 4.48e-26 Platelet count; CESC cis rs11122272 0.735 rs2486730 chr1:231534987 T/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg22875332 chr1:76189707 ACADM 0.63 6.2 0.36 2.17e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg12386194 chr3:101231763 SENP7 0.42 5.24 0.31 3.3e-7 Colorectal cancer; CESC cis rs8180040 0.726 rs6774733 chr3:46991241 G/A cg27129171 chr3:47204927 SETD2 0.65 9.42 0.5 2.28e-18 Colorectal cancer; CESC cis rs7809950 1.000 rs2520268 chr7:107191161 T/A cg23024343 chr7:107201750 COG5 -0.46 -6.2 -0.36 2.11e-9 Coronary artery disease; CESC cis rs11030122 0.702 rs10767702 chr11:3934132 T/C cg18678763 chr11:4115507 RRM1 -0.48 -6.35 -0.36 9.37e-10 Mean platelet volume;Platelet distribution width; CESC cis rs11792861 0.926 rs76689835 chr9:111833792 G/A cg05043794 chr9:111880884 C9orf5 -0.4 -6.53 -0.37 3.36e-10 Menarche (age at onset); CESC cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.56 0.37 2.8e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3815700 0.920 rs10426856 chr19:33096406 A/G cg02997394 chr19:33096574 ANKRD27 0.71 7.16 0.4 7.91e-12 Eosinophilic esophagitis; CESC trans rs648516 0.765 rs9532193 chr13:38835243 C/T cg14728235 chr20:57415177 GNASAS;GNAS -0.35 -6.21 -0.36 2.05e-9 Schizophrenia; CESC cis rs6690583 0.562 rs6665436 chr1:85532894 T/C cg22488158 chr1:85528044 WDR63 0.58 5.6 0.33 5.43e-8 Serum sulfate level; CESC cis rs6546550 0.901 rs6716937 chr2:70127229 G/A cg02498382 chr2:70120550 SNRNP27 -0.41 -7.26 -0.41 4.34e-12 Prevalent atrial fibrillation; CESC cis rs7617773 0.779 rs9833309 chr3:48327450 C/T cg11946769 chr3:48343235 NME6 0.8 10.89 0.56 4.71e-23 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14107975 chr11:96076498 MAML2 0.44 6.15 0.35 2.79e-9 Gut microbiota (bacterial taxa); CESC cis rs2204008 0.774 rs3910796 chr12:38230660 G/T cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs2991971 0.810 rs2356413 chr1:45914048 A/T cg15605315 chr1:45957053 TESK2 -0.39 -5.31 -0.31 2.27e-7 High light scatter reticulocyte count; CESC cis rs3768617 0.811 rs12043805 chr1:183008150 T/A ch.1.3577855R chr1:183094577 LAMC1 0.65 8.89 0.48 9.94e-17 Fuchs's corneal dystrophy; CESC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg03709012 chr19:19516395 GATAD2A 1.01 15.71 0.69 9.73e-40 Tonsillectomy; CESC cis rs6582630 0.555 rs10880421 chr12:38423015 C/T cg13010199 chr12:38710504 ALG10B 0.52 6.63 0.38 1.88e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs3008870 0.755 rs2755243 chr1:67482783 T/C cg02640540 chr1:67518911 SLC35D1 0.45 5.43 0.32 1.25e-7 Lymphocyte percentage of white cells; CESC cis rs12791968 1.000 rs11038237 chr11:45001880 C/T cg11846598 chr11:44996168 LOC221122 -0.55 -7.37 -0.41 2.23e-12 Inhibitory control; CESC cis rs1499614 1.000 rs2707840 chr7:66158015 C/T cg18252515 chr7:66147081 NA -1.43 -14.62 -0.67 6.65e-36 Gout; CESC cis rs8072100 0.570 rs9905073 chr17:45468296 G/A cg08085267 chr17:45401833 C17orf57 -0.52 -6.67 -0.38 1.49e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1670533 1.000 rs6852558 chr4:1059944 C/T cg04106633 chr4:1044584 NA 0.4 5.19 0.3 4.15e-7 Recombination rate (females); CESC cis rs9611565 0.592 rs4822040 chr22:41963553 C/G cg06481639 chr22:41940642 POLR3H -0.58 -6.38 -0.36 7.93e-10 Vitiligo; CESC cis rs4481887 1.000 rs4244180 chr1:248471033 A/G cg00666640 chr1:248458726 OR2T12 0.4 6.57 0.37 2.7e-10 Common traits (Other); CESC cis rs2439831 0.850 rs28590651 chr15:44113016 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.7 6.71 0.38 1.15e-10 Lung cancer in ever smokers; CESC cis rs7208859 0.623 rs3752020 chr17:29111125 T/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1050631 1.000 rs1539822 chr18:33695943 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.44 5.67 0.33 3.75e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg08499158 chr17:42289980 UBTF -0.57 -7.58 -0.42 5.78e-13 Total body bone mineral density; CESC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg07936489 chr17:37558343 FBXL20 0.76 10.71 0.55 1.83e-22 Glomerular filtration rate (creatinine); CESC cis rs9914988 0.943 rs4794839 chr17:27131393 G/A cg20469991 chr17:27169893 C17orf63 -0.49 -5.29 -0.31 2.58e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg06499344 chr4:36245396 ARAP2 0.45 6.13 0.35 3.2e-9 Recombination measurement; CESC cis rs57709857 0.957 rs58279725 chr8:38212611 T/C cg01506891 chr8:38243824 LETM2 0.48 5.06 0.3 8.02e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.87 0.39 4.46e-11 Platelet count; CESC trans rs2018683 0.707 rs2391717 chr7:28971162 G/C cg19402173 chr7:128379420 CALU -0.54 -7.12 -0.4 1.01e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs367615 0.506 rs2963013 chr5:108775811 C/T cg17395555 chr5:108820864 NA -0.57 -9.84 -0.52 1.1e-19 Colorectal cancer (SNP x SNP interaction); CESC cis rs4253772 0.591 rs12167567 chr22:46659942 G/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.68 8.01 0.44 3.66e-14 LDL cholesterol;Cholesterol, total; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00169633 chr3:134093551 AMOTL2 -0.5 -6.02 -0.35 5.75e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01938359 chr5:1335135 CLPTM1L -0.57 -6.56 -0.37 2.76e-10 Gut microbiome composition (summer); CESC cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg23711669 chr6:146136114 FBXO30 0.97 14.47 0.66 2.25e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs3540 0.512 rs8033595 chr15:91083353 G/A cg22089800 chr15:90895588 ZNF774 -0.61 -8.27 -0.45 6.47e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9399135 0.935 rs4273704 chr6:135297520 G/T cg22676075 chr6:135203613 NA 0.52 7.21 0.4 5.94e-12 Red blood cell count; CESC cis rs3617 0.591 rs11918800 chr3:52868145 G/A cg07507251 chr3:52567010 NT5DC2 -0.32 -5.43 -0.32 1.27e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9814567 1.000 rs12490835 chr3:134223730 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -6.02 -0.35 5.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7084402 0.555 rs7069916 chr10:60271824 A/G cg07615347 chr10:60278583 BICC1 0.58 8.85 0.48 1.23e-16 Refractive error; CESC cis rs4900538 0.819 rs72698595 chr14:102863099 G/A cg18135206 chr14:102964638 TECPR2 -0.69 -8.65 -0.47 4.88e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs9303401 0.614 rs12947982 chr17:57140301 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.87 10.82 0.55 7.81e-23 Cognitive test performance; CESC cis rs4654899 0.865 rs61779073 chr1:21398740 C/A cg05370193 chr1:21551575 ECE1 0.43 6.6 0.38 2.2e-10 Superior frontal gyrus grey matter volume; CESC trans rs7178375 1.000 rs12907055 chr15:31204294 C/G cg04373760 chr16:53404718 NA 0.55 7.36 0.41 2.26e-12 Hypertriglyceridemia; CESC cis rs7223966 1.000 rs8076717 chr17:61850301 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.44 5.13 0.3 5.71e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs11229555 0.645 rs36002376 chr11:58204809 C/G cg15696309 chr11:58395628 NA -0.42 -5.05 -0.3 8.13e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs2070488 0.965 rs35553573 chr3:38441439 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.94 17.41 0.73 8.52e-46 Electrocardiographic conduction measures; CESC cis rs16910800 0.731 rs56067480 chr11:23190184 C/T cg20040320 chr11:23191996 NA -0.67 -6.66 -0.38 1.53e-10 Cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21774377 chr6:34760070 UHRF1BP1 -0.43 -6.02 -0.35 5.74e-9 Gambling; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14899547 chr2:113521923 CKAP2L -0.42 -6.22 -0.36 1.91e-9 Gambling; CESC cis rs11048434 0.736 rs933462 chr12:9103665 T/G cg23795048 chr12:9217529 LOC144571 0.36 5.54 0.32 7.22e-8 Sjögren's syndrome; CESC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.32 0.31 2.24e-7 Menopause (age at onset); CESC cis rs7851660 0.839 rs10818213 chr9:100648631 T/C cg13688889 chr9:100608707 NA -0.63 -8.79 -0.47 1.99e-16 Strep throat; CESC cis rs2273669 0.667 rs1424479 chr6:109355790 G/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs9831754 0.906 rs4680929 chr3:78387591 T/A cg06138941 chr3:78371609 NA -0.66 -7.84 -0.43 1.12e-13 Calcium levels; CESC cis rs6121246 0.567 rs2811 chr20:30194248 A/G cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg01416388 chr22:39784598 NA -0.58 -7.42 -0.41 1.58e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9815354 0.812 rs73069292 chr3:41973963 T/C cg03022575 chr3:42003672 ULK4 0.67 5.96 0.34 7.91e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9323205 0.953 rs7141012 chr14:51600948 C/G cg23942311 chr14:51606299 NA -0.46 -5.46 -0.32 1.07e-7 Cancer; CESC cis rs7208859 0.623 rs55811708 chr17:29104731 G/T cg13385521 chr17:29058706 SUZ12P 0.77 6.15 0.35 2.81e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg25342872 chr17:79175132 AZI1 -0.49 -6.42 -0.37 6.41e-10 Frontotemporal dementia; CESC cis rs55728055 0.661 rs56411340 chr22:31984476 G/T cg01338084 chr22:32026380 PISD 1.26 8.55 0.47 9.7e-16 Age-related hearing impairment; CESC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg11965913 chr1:205819406 PM20D1 0.42 6.04 0.35 5.12e-9 Menarche (age at onset); CESC cis rs2228479 0.850 rs11640209 chr16:89807828 C/A cg04013166 chr16:89971882 TCF25 0.77 6.63 0.38 1.9e-10 Skin colour saturation; CESC cis rs7267979 1.000 rs1046073 chr20:25281333 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg11817910 chr12:31944836 H3F3C -0.46 -6.37 -0.36 8.44e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7512552 0.839 rs834236 chr1:150362968 C/T cg15654264 chr1:150340011 RPRD2 0.4 5.28 0.31 2.65e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs9831754 0.906 rs2102601 chr3:78410536 G/A cg06138941 chr3:78371609 NA -0.62 -7.66 -0.43 3.55e-13 Calcium levels; CESC cis rs2463822 0.748 rs2513053 chr11:62109473 T/A cg06239285 chr11:62104954 ASRGL1 0.87 8.78 0.47 2.03e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.8 0.39 6.78e-11 Bipolar disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12870750 chr17:7791882 CHD3 -0.43 -6.51 -0.37 3.67e-10 Gut microbiota (bacterial taxa); CESC cis rs8044995 0.925 rs9928653 chr16:68252079 T/C cg26727032 chr16:67993705 SLC12A4 -0.59 -8.47 -0.46 1.68e-15 Schizophrenia; CESC cis rs2180341 1.000 rs3798853 chr6:127636823 C/T cg24812749 chr6:127587940 RNF146 -1.04 -14.09 -0.65 4.99e-34 Breast cancer; CESC cis rs881375 0.678 rs10760125 chr9:123662590 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.66 0.43 3.56e-13 Rheumatoid arthritis; CESC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg25067162 chr17:41277974 BRCA1;NBR2 0.46 6.4 0.37 6.98e-10 Menopause (age at onset); CESC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg05861140 chr6:150128134 PCMT1 -0.35 -5.18 -0.3 4.37e-7 Lung cancer; CESC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg19163074 chr7:65112434 INTS4L2 0.43 5.51 0.32 8.54e-8 Aortic root size; CESC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg05564831 chr3:52568323 NT5DC2 0.46 7.19 0.4 6.63e-12 Intelligence (multi-trait analysis); CESC cis rs3820928 0.874 rs1917125 chr2:227798981 G/A cg05526886 chr2:227700861 RHBDD1 -0.4 -5.1 -0.3 6.49e-7 Pulmonary function; CESC cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.05 10.4 0.54 1.77e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2599510 0.840 rs466146 chr2:32539236 A/C cg02381751 chr2:32503542 YIPF4 0.5 6.6 0.38 2.25e-10 Interleukin-18 levels; CESC trans rs61931739 0.500 rs11053213 chr12:34466395 G/T cg13010199 chr12:38710504 ALG10B 0.49 6.29 0.36 1.3e-9 Morning vs. evening chronotype; CESC cis rs8133932 0.654 rs369245 chr21:47337821 G/A cg14185626 chr21:47401492 COL6A1 -0.45 -5.09 -0.3 6.84e-7 Schizophrenia; CESC cis rs1559088 0.948 rs3760893 chr19:33597930 C/A cg17764715 chr19:33622953 WDR88 0.49 6.5 0.37 4.04e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs72781680 0.898 rs72796166 chr2:23939311 G/C cg20701182 chr2:24300061 SF3B14 0.78 6.91 0.39 3.5e-11 Lymphocyte counts; CESC cis rs1949733 0.701 rs940136 chr4:8448992 G/A cg11789530 chr4:8429930 ACOX3 0.76 11.1 0.56 9.27e-24 Response to antineoplastic agents; CESC cis rs3096299 0.967 rs28689480 chr16:89460093 T/C cg02187348 chr16:89574699 SPG7 0.57 7.44 0.42 1.41e-12 Multiple myeloma (IgH translocation); CESC cis rs933688 1.000 rs10045280 chr5:90717675 T/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.11 15.83 0.7 3.48e-40 Smoking behavior; CESC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg18876405 chr7:65276391 NA -0.57 -7.4 -0.41 1.78e-12 Aortic root size; CESC trans rs9646096 0.681 rs1853325 chr13:38001186 A/G cg01311313 chr8:35252359 UNC5D 0.51 6.04 0.35 5.22e-9 Age-related macular degeneration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12402495 chr1:154192844 C1orf43;UBAP2L -0.41 -6.04 -0.35 5.08e-9 Gambling; CESC cis rs11792861 0.890 rs3087979 chr9:111781779 T/C cg13535736 chr9:111863775 C9orf5 -0.51 -6.69 -0.38 1.35e-10 Menarche (age at onset); CESC cis rs6496667 0.821 rs13329289 chr15:90897454 C/T cg22089800 chr15:90895588 ZNF774 0.57 5.76 0.33 2.27e-8 Rheumatoid arthritis; CESC cis rs6728642 0.803 rs11891458 chr2:97632450 G/T cg26665480 chr2:98280029 ACTR1B -0.72 -7.76 -0.43 1.9e-13 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs6570726 0.846 rs6570700 chr6:145931552 A/G cg05347473 chr6:146136440 FBXO30 0.5 6.57 0.37 2.6e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg23172400 chr8:95962367 TP53INP1 0.38 6.73 0.38 1.06e-10 Type 2 diabetes; CESC trans rs61931739 0.500 rs7977194 chr12:34408459 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.54 0.54 6.55e-22 Morning vs. evening chronotype; CESC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg01341218 chr17:43662625 NA 0.92 10.51 0.54 8.08e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1062177 0.774 rs2964574 chr5:151155711 G/A cg12924095 chr5:151150029 G3BP1 0.46 6.04 0.35 5.19e-9 Preschool internalizing problems; CESC cis rs10791097 0.547 rs10791101 chr11:130739133 C/T cg12179176 chr11:130786555 SNX19 0.69 10.31 0.53 3.6e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg11494091 chr17:61959527 GH2 0.76 13.11 0.63 1.31e-30 Prudent dietary pattern; CESC cis rs2948294 0.588 rs12544596 chr8:8116346 A/T cg15556689 chr8:8085844 FLJ10661 0.52 6.12 0.35 3.28e-9 Red cell distribution width; CESC cis rs7959452 0.640 rs10878957 chr12:69699638 G/C cg20891283 chr12:69753455 YEATS4 0.77 11.22 0.57 3.75e-24 Blood protein levels; CESC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg23758822 chr17:41437982 NA 1.02 15.6 0.69 2.35e-39 Menopause (age at onset); CESC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg18538332 chr22:24372958 LOC391322 -0.77 -11.07 -0.56 1.2e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs11190604 1.000 rs57025426 chr10:102205868 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs9790314 0.846 rs4470535 chr3:160974468 G/A cg03342759 chr3:160939853 NMD3 -0.46 -6.33 -0.36 1.06e-9 Morning vs. evening chronotype; CESC cis rs6499255 1.000 rs60231938 chr16:69830415 G/A cg15192750 chr16:69999425 NA 0.43 5.35 0.31 1.91e-7 IgE levels; CESC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg00166722 chr3:10149974 C3orf24 0.45 5.91 0.34 1.07e-8 Alzheimer's disease; CESC cis rs116095464 0.558 rs7356561 chr5:284381 G/C cg22857025 chr5:266934 NA -1.29 -18.38 -0.75 3.21e-49 Breast cancer; CESC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg18876405 chr7:65276391 NA 0.57 7.64 0.42 4.04e-13 Aortic root size; CESC cis rs6493487 0.512 rs28642856 chr15:51245680 T/C cg02338191 chr15:51200825 AP4E1 0.63 5.86 0.34 1.39e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4132509 0.744 rs320305 chr1:243859909 G/T cg21452805 chr1:244014465 NA 0.51 5.95 0.34 8.47e-9 RR interval (heart rate); CESC cis rs2204008 0.527 rs1315367 chr12:38177487 G/T cg26384229 chr12:38710491 ALG10B -0.41 -5.63 -0.33 4.55e-8 Bladder cancer; CESC cis rs7086627 0.515 rs11202959 chr10:82209672 A/G cg00277334 chr10:82204260 NA -0.91 -15.92 -0.7 1.67e-40 Post bronchodilator FEV1; CESC cis rs13385 0.813 rs57294361 chr5:139665761 C/T cg26211634 chr5:139558579 C5orf32 0.48 5.08 0.3 7.13e-7 Atrial fibrillation; CESC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.49 -5.71 -0.33 3.05e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6500395 1.000 rs7185899 chr16:48714101 A/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs617791 0.530 rs10791835 chr11:65750924 C/A cg02427764 chr11:65769310 BANF1;EIF1AD -0.43 -5.07 -0.3 7.34e-7 Breast cancer; CESC cis rs854765 0.929 rs2955360 chr17:17974887 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.42 -5.66 -0.33 3.87e-8 Total body bone mineral density; CESC cis rs4481887 0.597 rs11488132 chr1:248542353 A/G cg00666640 chr1:248458726 OR2T12 0.38 5.48 0.32 1e-7 Common traits (Other); CESC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.24 0.36 1.77e-9 Menopause (age at onset); CESC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg07395648 chr5:131743802 NA -0.39 -5.13 -0.3 5.7e-7 Blood metabolite levels; CESC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg19077165 chr18:44547161 KATNAL2 -0.54 -7.98 -0.44 4.51e-14 Personality dimensions; CESC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg10494973 chr17:80897199 TBCD 0.5 5.72 0.33 2.94e-8 Breast cancer; CESC cis rs6991838 0.584 rs6994213 chr8:66513732 A/G cg13398993 chr8:66546079 ARMC1 -0.47 -5.71 -0.33 2.95e-8 Intelligence (multi-trait analysis); CESC cis rs35110281 0.666 rs9977076 chr21:45085829 G/A cg04455712 chr21:45112962 RRP1B 0.49 7.53 0.42 8.22e-13 Mean corpuscular volume; CESC cis rs854765 0.583 rs7214002 chr17:17852104 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.65 9.42 0.5 2.29e-18 Total body bone mineral density; CESC cis rs8067545 0.611 rs6587219 chr17:20034531 T/G cg13482628 chr17:19912719 NA 0.39 5.12 0.3 5.84e-7 Schizophrenia; CESC cis rs9916302 0.706 rs1054488 chr17:37687968 A/G cg07936489 chr17:37558343 FBXL20 -0.98 -11.47 -0.58 5.54e-25 Glomerular filtration rate (creatinine); CESC cis rs959260 1.000 rs930299 chr17:73404668 A/C cg12999837 chr17:73267436 MIF4GD -0.49 -5.53 -0.32 7.69e-8 Systemic lupus erythematosus; CESC cis rs3857536 0.776 rs6941904 chr6:66931042 A/G cg07460842 chr6:66804631 NA -0.42 -5.36 -0.31 1.8e-7 Blood trace element (Cu levels); CESC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 4.97e-9 Prudent dietary pattern; CESC cis rs2191566 0.691 rs62115513 chr19:44587192 T/C cg20607764 chr19:44506953 ZNF230 -0.4 -5.18 -0.3 4.33e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs16921914 0.565 rs286650 chr11:31230207 T/C cg14844989 chr11:31128820 NA -0.42 -5.94 -0.34 8.79e-9 Bone mineral density (spine); CESC cis rs7680126 0.596 rs17198547 chr4:10141419 A/G cg00071950 chr4:10020882 SLC2A9 0.48 5.97 0.34 7.51e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs35952432 1 rs35952432 chr6:28074901 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.84 5.42 0.32 1.35e-7 Lung cancer; CESC cis rs13191362 0.935 rs34540135 chr6:162934351 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.73 6.4 0.37 6.88e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg26314531 chr2:26401878 FAM59B -0.59 -6.67 -0.38 1.5e-10 Gut microbiome composition (summer); CESC cis rs7845219 0.525 rs6471501 chr8:95922491 A/G cg09323728 chr8:95962352 TP53INP1 -0.35 -6.75 -0.38 9.36e-11 Type 2 diabetes; CESC cis rs3020736 0.500 rs2413672 chr22:42513261 C/T cg15557168 chr22:42548783 NA 0.45 6.51 0.37 3.78e-10 Autism spectrum disorder or schizophrenia; CESC cis rs920590 0.510 rs4922101 chr8:19648895 A/G cg01411142 chr8:19674711 INTS10 0.59 5.93 0.34 9.53e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg17372223 chr3:52568218 NT5DC2 0.45 6.61 0.38 2.14e-10 Bipolar disorder; CESC trans rs7726839 0.561 rs3915384 chr5:573395 G/T cg25482853 chr8:67687455 SGK3 0.85 8.71 0.47 3.29e-16 Obesity-related traits; CESC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg26304593 chr6:42947056 PEX6 -0.45 -5.8 -0.34 1.9e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg08968635 chr6:28129556 ZNF389 0.42 5.72 0.33 2.82e-8 Depression; CESC cis rs8020095 0.528 rs8007696 chr14:67822459 T/C cg19548862 chr14:67692701 FAM71D -0.45 -5.34 -0.31 2.04e-7 Depression (quantitative trait); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27051171 chr2:7005923 CMPK2 -0.49 -6.69 -0.38 1.36e-10 Fibrinogen levels; CESC cis rs2455799 0.613 rs7617039 chr3:15800740 A/G cg16303742 chr3:15540471 COLQ 0.35 5.24 0.31 3.21e-7 Mean platelet volume; CESC cis rs830124 0.602 rs1184893 chr12:122403811 G/A cg22168489 chr12:122356033 WDR66 -0.39 -5.07 -0.3 7.4e-7 Urinary metabolites; CESC cis rs3806843 0.735 rs702394 chr5:140086786 A/G cg16179182 chr5:140090404 VTRNA1-1 0.42 5.51 0.32 8.71e-8 Depressive symptoms (multi-trait analysis); CESC trans rs877282 0.891 rs10904557 chr10:797490 C/T cg22713356 chr15:30763199 NA -1.29 -13.34 -0.63 2.03e-31 Uric acid levels; CESC cis rs4727027 0.933 rs13225884 chr7:148857795 A/G cg23583168 chr7:148888333 NA -0.79 -12.2 -0.6 1.82e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01362762 chr13:114805400 RASA3 -0.52 -6.24 -0.36 1.75e-9 Gut microbiome composition (summer); CESC cis rs2072499 0.966 rs2244144 chr1:156184598 G/A cg25208724 chr1:156163844 SLC25A44 0.95 15.35 0.69 1.82e-38 Testicular germ cell tumor; CESC cis rs151234 0.741 rs151229 chr16:28584937 G/A cg01378222 chr16:28622494 SULT1A1 -0.57 -7.2 -0.4 6.37e-12 Platelet distribution width; CESC cis rs7312774 0.748 rs7966019 chr12:107297502 G/T cg16260113 chr12:107380972 MTERFD3 0.62 5.73 0.33 2.73e-8 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22236469 chr5:149111272 PPARGC1B -0.59 -6.44 -0.37 5.65e-10 Gut microbiome composition (summer); CESC cis rs10463316 0.894 rs13361316 chr5:150765593 T/C cg03212797 chr5:150827313 SLC36A1 -0.46 -5.96 -0.34 8.11e-9 Metabolite levels (Pyroglutamine); CESC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg10862848 chr6:42927986 GNMT -0.26 -6.54 -0.37 3.18e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs6060717 0.553 rs2590958 chr20:34616590 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.49 6.22 0.36 1.96e-9 Hip circumference adjusted for BMI; CESC cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg22862634 chr11:62369728 EML3;MTA2 0.6 8.51 0.46 1.33e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs35110281 0.837 rs2838336 chr21:45071741 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.5 -6.6 -0.38 2.23e-10 Mean corpuscular volume; CESC cis rs9660992 0.573 rs1172161 chr1:205206495 C/T cg00857998 chr1:205179979 DSTYK 0.56 6.88 0.39 4.29e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs6714710 0.580 rs11680018 chr2:98479581 C/A cg26665480 chr2:98280029 ACTR1B 0.6 8.2 0.45 1.01e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs950169 0.881 rs4081123 chr15:84956235 A/G cg17507749 chr15:85114479 UBE2QP1 0.59 6.54 0.37 3.11e-10 Schizophrenia; CESC cis rs4323050 0.514 rs28647406 chr4:144905590 A/T cg25736465 chr4:144833511 NA 0.41 6.25 0.36 1.65e-9 High light scatter reticulocyte percentage of red cells; CESC cis rs950776 0.518 rs12907169 chr15:78825498 G/C cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg22601191 chr20:60968625 CABLES2 -0.41 -5.76 -0.33 2.28e-8 Colorectal cancer; CESC cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg00750074 chr16:89608354 SPG7 0.4 5.73 0.33 2.72e-8 Multiple myeloma (IgH translocation); CESC cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7219021 0.886 rs8068884 chr17:46869898 G/C cg16584676 chr17:46985605 UBE2Z -0.55 -6.3 -0.36 1.25e-9 Schizophrenia or bipolar disorder; CESC cis rs8072100 0.570 rs9905073 chr17:45468296 G/A cg25173405 chr17:45401733 C17orf57 -0.44 -5.65 -0.33 4.14e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs5995756 0.761 rs6001639 chr22:40003309 C/A cg03390717 chr22:39966585 CACNA1I -0.29 -5.07 -0.3 7.57e-7 Autism spectrum disorder or schizophrenia; CESC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg23172400 chr8:95962367 TP53INP1 -0.45 -9.25 -0.49 8.02e-18 Type 2 diabetes; CESC cis rs4664293 1.000 rs4665083 chr2:160430127 C/T cg08347373 chr2:160653686 CD302 0.34 5.56 0.32 6.65e-8 Monocyte percentage of white cells; CESC cis rs6754311 0.773 rs632632 chr2:136638216 A/G cg07169764 chr2:136633963 MCM6 0.67 8.17 0.45 1.23e-14 Mosquito bite size; CESC trans rs7937682 1.000 rs7121011 chr11:111568681 C/T cg18187862 chr3:45730750 SACM1L -0.53 -6.07 -0.35 4.52e-9 Primary sclerosing cholangitis; CESC cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg00080972 chr5:178986291 RUFY1 0.44 6.84 0.39 5.46e-11 Lung cancer; CESC cis rs6088590 1.000 rs3787222 chr20:33333040 T/A cg08999081 chr20:33150536 PIGU 0.6 9.27 0.49 6.6e-18 Coronary artery disease; CESC cis rs863345 0.625 rs950487 chr1:158460130 A/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.14 -0.4 8.93e-12 Pneumococcal bacteremia; CESC cis rs9926296 0.609 rs4785714 chr16:89798404 G/T cg04287289 chr16:89883240 FANCA -0.65 -8.79 -0.48 1.88e-16 Vitiligo; CESC cis rs4298948 0.590 rs11043250 chr12:122372815 A/C cg13699009 chr12:122356056 WDR66 0.46 5.43 0.32 1.31e-7 Obesity-related traits; CESC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg19622623 chr12:86230825 RASSF9 -0.47 -5.95 -0.34 8.28e-9 Major depressive disorder; CESC cis rs9303401 0.614 rs3887355 chr17:56538639 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.98 11.87 0.59 2.46e-26 Cognitive test performance; CESC cis rs1865760 0.566 rs1800702 chr6:26086463 C/G cg17691542 chr6:26056736 HIST1H1C 0.42 5.57 0.32 6.13e-8 Height; CESC cis rs1322639 0.657 rs9355135 chr6:169573006 C/T cg03254818 chr6:169586852 NA 0.55 5.91 0.34 1.02e-8 Pulse pressure; CESC cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC trans rs9467711 0.606 rs9393710 chr6:26367833 A/G cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC cis rs4481887 0.962 rs5009868 chr1:248474495 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.71 0.38 1.15e-10 Common traits (Other); CESC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg14829155 chr15:31115871 NA -0.72 -9.92 -0.52 6.44e-20 Huntington's disease progression; CESC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg14262678 chr6:151773367 RMND1;C6orf211 0.67 9.92 0.52 6.22e-20 Menarche (age at onset); CESC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg11663144 chr21:46675770 NA -0.62 -9.68 -0.51 3.65e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg09509183 chr1:209979624 IRF6 -0.4 -5.42 -0.32 1.31e-7 Monobrow; CESC trans rs11159647 0.636 rs34944551 chr14:84735341 T/C cg19838074 chr2:242149865 ANO7 0.41 6.04 0.35 5.21e-9 Alzheimer's disease; CESC cis rs9929218 1.000 rs28450087 chr16:68803726 T/G cg02972257 chr16:68554789 NA 0.43 5.18 0.3 4.44e-7 Colorectal cancer; CESC cis rs6032067 0.636 rs6032095 chr20:43913255 A/T cg10761708 chr20:43804764 PI3 -0.37 -5.26 -0.31 3.02e-7 Blood protein levels; CESC cis rs4953318 0.704 rs10495927 chr2:46352499 A/G cg12428440 chr2:46370979 PRKCE 0.46 6.55 0.37 2.96e-10 Red blood cell count;Hematocrit;Red blood cell traits; CESC cis rs9399137 0.507 rs11759062 chr6:135381248 A/C cg22676075 chr6:135203613 NA 0.53 7.01 0.4 1.95e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7923609 1.000 rs10761727 chr10:64995493 C/T cg01631684 chr10:65280961 REEP3 -0.45 -5.56 -0.32 6.57e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs561341 1.000 rs506766 chr17:30289659 T/C cg19193384 chr17:30244184 NA -0.7 -6.24 -0.36 1.7e-9 Hip circumference adjusted for BMI; CESC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg12463550 chr7:65579703 CRCP 0.5 6.36 0.36 8.85e-10 Aortic root size; CESC cis rs10242455 0.571 rs80045298 chr7:99307453 T/A cg25640893 chr7:99214727 ZNF498 0.85 5.73 0.33 2.69e-8 Blood metabolite levels; CESC cis rs11249608 0.548 rs7704565 chr5:178473923 G/C cg21905437 chr5:178450457 ZNF879 0.57 7.81 0.43 1.34e-13 Pubertal anthropometrics; CESC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.71 0.58 8.13e-26 Platelet count; CESC cis rs6089584 0.893 rs6089305 chr20:60571817 T/C cg06108461 chr20:60628389 TAF4 -0.8 -11.87 -0.59 2.44e-26 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22185043 chr18:12947723 SEH1L -0.45 -6.25 -0.36 1.59e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7246657 0.943 rs2081096 chr19:37964700 G/A cg24637308 chr11:6592297 DNHD1 0.53 6.22 0.36 1.9e-9 Coronary artery calcification; CESC cis rs6424115 0.729 rs1737362 chr1:24054800 T/C cg15997130 chr1:24165203 NA 0.41 5.48 0.32 1.01e-7 Immature fraction of reticulocytes; CESC cis rs3008870 0.792 rs72673729 chr1:67441673 T/TG cg02640540 chr1:67518911 SLC35D1 -0.53 -5.73 -0.33 2.71e-8 Lymphocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27021056 chr17:76837047 USP36 0.56 6.49 0.37 4.1e-10 Gut microbiome composition (summer); CESC cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.48 6.2 0.36 2.21e-9 Colorectal cancer; CESC cis rs6570726 0.846 rs6919684 chr6:145883801 A/G cg23711669 chr6:146136114 FBXO30 0.92 13.86 0.65 3.11e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs2204008 0.774 rs11616004 chr12:38278822 G/A cg13010199 chr12:38710504 ALG10B 0.52 6.38 0.36 8.04e-10 Bladder cancer; CESC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg05861140 chr6:150128134 PCMT1 -0.35 -5.11 -0.3 6.19e-7 Lung cancer; CESC cis rs11690935 0.632 rs62184165 chr2:172558328 A/G cg13550731 chr2:172543902 DYNC1I2 0.59 8.33 0.46 4.51e-15 Schizophrenia; CESC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg02275930 chr1:2372054 NA -0.48 -8.31 -0.45 5.05e-15 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13464876 chr9:111881992 C9orf5 -0.48 -6.41 -0.37 6.71e-10 Fibrinogen levels; CESC cis rs9811920 0.683 rs16841874 chr3:99720564 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.4 -6.51 -0.37 3.68e-10 Axial length; CESC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg27572855 chr1:25598939 RHD 0.5 8.45 0.46 1.99e-15 Erythrocyte sedimentation rate; CESC trans rs3741489 1.000 rs75810241 chr12:133365186 G/A cg24132527 chr5:140019269 TMCO6 1.16 7.05 0.4 1.55e-11 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02842627 chr3:49967264 MON1A 0.57 6.3 0.36 1.24e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16430402 chr1:5947386 NPHP4 0.45 6.06 0.35 4.57e-9 Fibrinogen levels; CESC cis rs208346 1.000 rs208346 chr7:2799686 G/T cg09658497 chr7:2847517 GNA12 0.38 6.03 0.35 5.38e-9 Loneliness (linear analysis); CESC cis rs2637266 0.846 rs2583045 chr10:78412385 C/G cg18941641 chr10:78392320 NA -0.43 -7.94 -0.44 5.6e-14 Pulmonary function; CESC cis rs782590 0.837 rs782573 chr2:55912961 T/C cg18811423 chr2:55921094 PNPT1 0.8 12.8 0.62 1.6e-29 Metabolic syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18470468 chr7:98985742 ARPC1B -0.57 -6.24 -0.36 1.69e-9 Gut microbiome composition (summer); CESC cis rs2242663 0.798 rs1791679 chr11:66337874 C/A cg24851651 chr11:66362959 CCS 0.4 5.11 0.3 6.21e-7 Bipolar disorder; CESC cis rs7100689 0.598 rs35353819 chr10:82135737 A/G cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 10.3 0.53 3.89e-21 Platelet count; CESC cis rs72945132 0.882 rs3133179 chr11:70187574 T/G cg00319359 chr11:70116639 PPFIA1 0.71 6.92 0.39 3.49e-11 Coronary artery disease; CESC cis rs72627123 0.867 rs73301493 chr14:74472197 C/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.8 5.77 0.33 2.2e-8 Morning vs. evening chronotype; CESC cis rs2933343 0.630 rs75824035 chr3:128652985 T/C cg24203234 chr3:128598194 ACAD9 0.45 6.07 0.35 4.37e-9 IgG glycosylation; CESC cis rs73058052 1.000 rs2288920 chr19:50091798 G/T cg09250473 chr19:50168907 IRF3;BCL2L12 0.59 5.74 0.33 2.55e-8 Fibrinogen levels; CESC cis rs950776 0.531 rs12915652 chr15:78831928 G/A cg24631222 chr15:78858424 CHRNA5 -0.42 -5.35 -0.31 1.95e-7 Sudden cardiac arrest; CESC trans rs10435719 0.678 rs74724594 chr8:11790576 C/A cg15556689 chr8:8085844 FLJ10661 0.52 6.36 0.36 8.63e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs2070677 0.736 rs4529856 chr10:135414020 C/G cg20169779 chr10:135381914 SYCE1 -0.8 -8.86 -0.48 1.23e-16 Gout; CESC cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg03433033 chr1:76189801 ACADM -0.67 -7.91 -0.44 7.05e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs8017423 0.647 rs4904677 chr14:90819245 C/T cg14092571 chr14:90743983 NA 0.44 6.62 0.38 1.93e-10 Mortality in heart failure; CESC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs72945132 0.882 rs7935969 chr11:70194175 G/A cg14191688 chr11:70257035 CTTN 0.41 5.13 0.3 5.6e-7 Coronary artery disease; CESC cis rs6088580 0.634 rs4911420 chr20:32998654 A/G cg06115741 chr20:33292138 TP53INP2 -0.42 -5.52 -0.32 7.92e-8 Glomerular filtration rate (creatinine); CESC cis rs4660261 0.526 rs2906458 chr1:44336389 A/G cg12908607 chr1:44402522 ARTN 0.48 7.07 0.4 1.4e-11 Intelligence (multi-trait analysis); CESC cis rs1144333 1.000 rs5745343 chr1:76273805 A/G cg10523679 chr1:76189770 ACADM -0.57 -5.84 -0.34 1.55e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs787274 0.718 rs2185768 chr9:115462645 C/T cg13803584 chr9:115635662 SNX30 0.51 5.05 0.3 8.34e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs963731 0.579 rs6544195 chr2:39288486 A/G cg04010122 chr2:39346883 SOS1 -0.72 -5.63 -0.33 4.52e-8 Corticobasal degeneration; CESC cis rs7084402 0.967 rs1619284 chr10:60302515 C/T cg07615347 chr10:60278583 BICC1 0.63 10.02 0.52 2.94e-20 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02262786 chr10:103816019 C10orf76 -0.55 -6.21 -0.36 1.99e-9 Gut microbiome composition (summer); CESC cis rs1185460 1.000 rs1614264 chr11:118942638 A/C cg01677386 chr11:118938358 VPS11 -0.44 -5.48 -0.32 9.86e-8 Coronary artery disease; CESC cis rs11249608 0.548 rs7732719 chr5:178463054 A/G cg21905437 chr5:178450457 ZNF879 0.58 8.14 0.45 1.56e-14 Pubertal anthropometrics; CESC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg17376030 chr22:41985996 PMM1 0.57 6.26 0.36 1.56e-9 Vitiligo; CESC cis rs11583043 0.708 rs3861736 chr1:101532657 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.43 0.32 1.27e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs5417 0.636 rs222851 chr17:7139238 G/A cg25256661 chr17:7137939 DVL2 0.56 7.51 0.42 9.25e-13 Diastolic blood pressure; CESC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.51 6.17 0.35 2.58e-9 Prudent dietary pattern; CESC cis rs854765 0.583 rs12452254 chr17:17829434 G/A cg16928487 chr17:17741425 SREBF1 -0.58 -9.9 -0.52 7.25e-20 Total body bone mineral density; CESC cis rs4595586 0.545 rs2218761 chr12:39393593 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.72 0.33 2.9e-8 Personality dimensions; CESC cis rs7762018 0.769 rs4716385 chr6:170127608 G/T cg13891659 chr6:170190454 C6orf122;C6orf208 0.61 5.89 0.34 1.18e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2249694 0.960 rs8192776 chr10:135348187 T/C cg20169779 chr10:135381914 SYCE1 0.38 5.22 0.31 3.55e-7 Obesity-related traits; CESC cis rs654950 0.806 rs1815257 chr1:42041479 A/C cg06885757 chr1:42089581 HIVEP3 -0.64 -10.14 -0.53 1.22e-20 Airway imaging phenotypes; CESC cis rs12410462 0.579 rs78343168 chr1:227621090 G/A cg04117972 chr1:227635322 NA 0.82 7.37 0.41 2.22e-12 Major depressive disorder; CESC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg23590916 chr17:43697445 MGC57346 0.64 6.77 0.38 8.3e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6598955 0.724 rs7526545 chr1:26569990 C/A cg04990556 chr1:26633338 UBXN11 -0.78 -11.35 -0.57 1.35e-24 Obesity-related traits; CESC cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg26597838 chr10:835615 NA 0.9 9.8 0.52 1.49e-19 Eosinophil percentage of granulocytes; CESC cis rs9814567 1.000 rs2370578 chr3:134199612 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.07 -0.35 4.34e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs8112211 0.911 rs60071299 chr19:38850246 G/A cg14299480 chr19:38876666 GGN -0.44 -6.03 -0.35 5.48e-9 Blood protein levels; CESC cis rs7914558 0.966 rs1971589 chr10:104744406 A/G cg15744005 chr10:104629667 AS3MT -0.33 -5.16 -0.3 4.81e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7662987 0.793 rs7669660 chr4:99992602 T/C cg13256891 chr4:100009986 ADH5 -0.59 -5.12 -0.3 5.89e-7 Smoking initiation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19355881 chr6:34759549 UHRF1BP1 0.55 6.97 0.39 2.44e-11 Gut microbiome composition (summer); CESC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg07157834 chr1:205819609 PM20D1 0.71 10.43 0.54 1.49e-21 Menarche (age at onset); CESC cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg26597838 chr10:835615 NA 0.7 6.53 0.37 3.31e-10 Eosinophil percentage of granulocytes; CESC cis rs6570726 0.935 rs399169 chr6:145836353 C/A cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.86 14.27 0.66 1.2e-34 Menarche (age at onset); CESC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg02725872 chr8:58115012 NA -0.4 -5.28 -0.31 2.65e-7 Developmental language disorder (linguistic errors); CESC cis rs7772486 0.790 rs2253654 chr6:146199445 T/C cg23711669 chr6:146136114 FBXO30 1.03 16.03 0.7 6.85e-41 Lobe attachment (rater-scored or self-reported); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17181325 chr17:1613831 TLCD2 0.46 6.37 0.36 8.11e-10 Gut microbiota (bacterial taxa); CESC trans rs3942852 0.774 rs10838813 chr11:48186969 C/A cg03929089 chr4:120376271 NA -0.65 -7.1 -0.4 1.15e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs6582630 0.577 rs12312748 chr12:38343326 T/C cg26384229 chr12:38710491 ALG10B -0.42 -5.48 -0.32 1.01e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg14440974 chr22:39074834 NA -0.41 -5.67 -0.33 3.72e-8 Menopause (age at onset); CESC cis rs1292059 1 rs1292059 chr17:57957888 T/A cg02344993 chr17:57696989 CLTC 0.52 5.44 0.32 1.19e-7 Eosinophil percentage of granulocytes; CESC cis rs2204008 0.548 rs2320740 chr12:38166421 G/A cg13010199 chr12:38710504 ALG10B 0.52 6.6 0.38 2.18e-10 Bladder cancer; CESC cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.34 0.46 4.2e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg03467027 chr4:99064603 C4orf37 0.44 5.48 0.32 9.97e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4604732 0.631 rs34443739 chr1:247626913 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.56 6.94 0.39 2.97e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg18876405 chr7:65276391 NA 0.46 5.24 0.31 3.3e-7 Aortic root size; CESC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 13.45 0.64 8.72e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2011503 1.000 rs75582668 chr19:19569023 C/T cg11584989 chr19:19387371 SF4 0.62 7.22 0.41 5.54e-12 Bipolar disorder; CESC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg06481639 chr22:41940642 POLR3H -0.6 -6.28 -0.36 1.35e-9 Vitiligo; CESC cis rs7561273 0.586 rs6545264 chr2:24310105 A/G cg01493198 chr2:24299560 SF3B14 0.42 5.16 0.3 4.85e-7 Quantitative traits; CESC cis rs9522267 0.535 rs11069899 chr13:112231553 T/C cg10483660 chr13:112241077 NA -0.32 -5.69 -0.33 3.28e-8 Hepatitis; CESC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg03806693 chr22:41940476 POLR3H -1.18 -14.45 -0.66 2.78e-35 Vitiligo; CESC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg07936489 chr17:37558343 FBXL20 0.81 11.93 0.59 1.5e-26 Glomerular filtration rate (creatinine); CESC cis rs748404 0.697 rs574065 chr15:43550655 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.62 -8.01 -0.44 3.68e-14 Lung cancer; CESC trans rs17508449 0.819 rs78874053 chr1:114242873 A/T cg23028848 chr11:57092561 TNKS1BP1 -0.81 -6.4 -0.37 6.98e-10 Leprosy; CESC cis rs7607369 0.559 rs4674340 chr2:219659799 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -7.23 -0.41 5.21e-12 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs6580649 0.843 rs3803184 chr12:48398002 G/C cg24011408 chr12:48396354 COL2A1 0.4 5.28 0.31 2.7e-7 Lung cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19463885 chr2:242626846 DTYMK -0.43 -6.21 -0.36 2.02e-9 Gambling; CESC cis rs3617 0.625 rs2071042 chr3:52864584 A/G cg11645453 chr3:52864694 ITIH4 0.26 5.18 0.3 4.39e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs12220238 1.000 rs12355771 chr10:75894404 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.65 6.13 0.35 3.23e-9 Soluble interleukin-2 receptor subunit alpha; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02442526 chr22:46973514 NA 0.66 7.26 0.41 4.36e-12 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18946802 chr3:14220310 LSM3;XPC -0.48 -6.15 -0.35 2.81e-9 Gut microbiota (bacterial taxa); CESC cis rs17854409 1.000 rs66956644 chr20:61484499 T/C cg05147244 chr20:61493195 TCFL5 0.99 6.48 0.37 4.57e-10 Obesity-related traits; CESC cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg05340658 chr4:99064831 C4orf37 0.84 12.86 0.62 9.41e-30 Colonoscopy-negative controls vs population controls; CESC cis rs61931739 0.500 rs10844864 chr12:34532468 A/G cg06521331 chr12:34319734 NA -0.37 -5.15 -0.3 5.19e-7 Morning vs. evening chronotype; CESC cis rs12477438 0.501 rs11123770 chr2:99825102 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.71 10.86 0.55 5.89e-23 Chronic sinus infection; CESC cis rs12618769 0.625 rs76362434 chr2:99118005 C/T cg10123293 chr2:99228465 UNC50 0.4 5.06 0.3 7.7e-7 Bipolar disorder; CESC cis rs35146811 0.771 rs1060544 chr7:99613476 C/T cg13334819 chr7:99746414 C7orf59 -0.45 -5.24 -0.31 3.34e-7 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11412766 chr2:55276306 RTN4 -0.51 -6.86 -0.39 4.9e-11 Ulcerative colitis; CESC cis rs425277 0.917 rs78395918 chr1:2045876 G/A cg16545954 chr1:2118288 C1orf86 0.33 5.4 0.31 1.48e-7 Height; CESC cis rs7100689 0.516 rs10788546 chr10:82034854 T/C cg00277334 chr10:82204260 NA -0.46 -5.76 -0.33 2.28e-8 Post bronchodilator FEV1; CESC cis rs7116495 0.609 rs17161751 chr11:71688347 G/A cg26138937 chr11:71823887 C11orf51 1.32 8.19 0.45 1.11e-14 Severe influenza A (H1N1) infection; CESC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg22535103 chr8:58192502 C8orf71 -0.95 -10.54 -0.54 6.39e-22 Developmental language disorder (linguistic errors); CESC cis rs3820068 0.544 rs7551750 chr1:16035008 T/C cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.35 4.28e-9 Systolic blood pressure; CESC cis rs4727027 0.899 rs11768971 chr7:148825826 C/G cg23158103 chr7:148848205 ZNF398 -0.41 -6.74 -0.38 9.65e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21659725 chr3:3221576 CRBN -0.82 -13.49 -0.64 6.48e-32 Intelligence (multi-trait analysis); CESC cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.37 5.17 0.3 4.64e-7 Schizophrenia; CESC cis rs4253772 0.637 rs6008339 chr22:46650846 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.18 0.45 1.16e-14 LDL cholesterol;Cholesterol, total; CESC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg11987759 chr7:65425863 GUSB -0.48 -6.62 -0.38 2.03e-10 Aortic root size; CESC cis rs478304 0.651 rs11227299 chr11:65549570 C/G cg10518572 chr11:65560635 OVOL1 -0.31 -5.85 -0.34 1.43e-8 Acne (severe); CESC cis rs3768617 0.528 rs10737242 chr1:183098249 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg05368731 chr17:41323189 NBR1 0.75 10.35 0.54 2.72e-21 Menopause (age at onset); CESC cis rs9457247 0.534 rs7750593 chr6:167387359 C/G cg25258033 chr6:167368657 RNASET2 -0.38 -5.44 -0.32 1.2e-7 Crohn's disease; CESC cis rs4268898 0.931 rs34504814 chr2:24503766 C/T cg20701182 chr2:24300061 SF3B14 0.47 5.65 0.33 4.1e-8 Asthma; CESC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg17724175 chr1:150552817 MCL1 0.41 6.3 0.36 1.24e-9 Melanoma; CESC trans rs208520 0.690 rs12213928 chr6:66762978 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.43 0.61 2.98e-28 Exhaled nitric oxide output; CESC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg11890956 chr21:40555474 PSMG1 1.07 16.6 0.71 6.4e-43 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26419957 chr12:122252518 SETD1B -0.69 -7.61 -0.42 4.73e-13 Gut microbiome composition (summer); CESC cis rs12822507 0.831 rs34975957 chr12:12786190 G/A cg09462578 chr12:12878428 APOLD1 -0.46 -5.71 -0.33 3.06e-8 Systemic lupus erythematosus; CESC cis rs11792861 0.962 rs72607161 chr9:111792640 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.46 5.76 0.33 2.35e-8 Menarche (age at onset); CESC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg05564831 chr3:52568323 NT5DC2 -0.45 -7.28 -0.41 3.73e-12 Bipolar disorder; CESC cis rs4253772 0.872 rs4253776 chr22:46629479 C/T cg18190219 chr22:46762943 CELSR1 0.51 6.25 0.36 1.65e-9 LDL cholesterol;Cholesterol, total; CESC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg04282206 chr17:62833786 PLEKHM1P 0.54 6.22 0.36 1.93e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7520050 0.966 rs6701614 chr1:46309420 G/C cg03146154 chr1:46216737 IPP -0.48 -6.3 -0.36 1.25e-9 Red blood cell count;Reticulocyte count; CESC cis rs344364 0.511 rs2906912 chr16:1953151 G/A cg26617929 chr16:1858877 NA -0.5 -5.22 -0.31 3.63e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg08888203 chr3:10149979 C3orf24 0.44 5.71 0.33 3.09e-8 Alzheimer's disease; CESC cis rs992157 0.560 rs4674274 chr2:219089131 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.57 -7.45 -0.42 1.29e-12 Colorectal cancer; CESC cis rs7809950 1.000 rs17154077 chr7:107077941 C/T cg23024343 chr7:107201750 COG5 0.39 5.54 0.32 7.4e-8 Coronary artery disease; CESC trans rs164368 0.568 rs163944 chr5:160633896 C/T cg04183933 chr2:198363868 HSPD1;HSPE1 -0.61 -6.52 -0.37 3.63e-10 Yu-Zhi constitution type in type 2 diabetes; CESC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg05564831 chr3:52568323 NT5DC2 0.46 6.57 0.37 2.67e-10 Bipolar disorder; CESC cis rs7223966 1.000 rs8074771 chr17:61735865 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.44 0.37 5.7e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7107174 1.000 rs729354 chr11:77962453 T/A cg02023728 chr11:77925099 USP35 0.46 6.49 0.37 4.25e-10 Testicular germ cell tumor; CESC cis rs10751667 0.666 rs7396059 chr11:970490 C/A cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.49e-7 Alzheimer's disease (late onset); CESC cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg14345882 chr6:26364793 BTN3A2 0.41 5.38 0.31 1.68e-7 Intelligence (multi-trait analysis); CESC cis rs4975616 0.836 rs421629 chr5:1320136 G/A cg26373071 chr5:1325741 CLPTM1L 0.41 6.45 0.37 5.29e-10 Lung cancer; CESC cis rs57221529 0.766 rs4957053 chr5:575927 T/C cg16447950 chr5:562315 NA -0.64 -6.81 -0.39 6.59e-11 Lung disease severity in cystic fibrosis; CESC cis rs7845219 0.544 rs34293080 chr8:95908078 G/T cg16049864 chr8:95962084 TP53INP1 -0.51 -7.59 -0.42 5.59e-13 Type 2 diabetes; CESC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg06028605 chr16:24865363 SLC5A11 0.53 7.71 0.43 2.47e-13 Intelligence (multi-trait analysis); CESC cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg00255919 chr5:131827918 IRF1 -0.37 -5.4 -0.31 1.5e-7 Breast cancer;Mosquito bite size; CESC cis rs7659604 1.000 rs7689722 chr4:122665955 T/C cg19671926 chr4:122722719 EXOSC9 -0.49 -5.92 -0.34 9.92e-9 Type 2 diabetes; CESC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.55 0.58 2.8e-25 Alzheimer's disease; CESC cis rs7116495 1.000 rs548961 chr11:71793887 G/A cg26138937 chr11:71823887 C11orf51 -0.86 -7.03 -0.4 1.75e-11 Severe influenza A (H1N1) infection; CESC cis rs2455799 0.613 rs4685258 chr3:15792315 G/A cg16303742 chr3:15540471 COLQ -0.39 -6.14 -0.35 3.01e-9 Mean platelet volume; CESC cis rs9790314 0.521 rs2122527 chr3:161091636 G/A cg03342759 chr3:160939853 NMD3 -0.45 -6.25 -0.36 1.6e-9 Morning vs. evening chronotype; CESC cis rs2777491 1.000 rs11631770 chr15:41737059 T/C cg20272979 chr15:41787780 ITPKA 0.43 6.18 0.36 2.34e-9 Ulcerative colitis; CESC cis rs67460515 0.892 rs13059340 chr3:161062631 T/C cg03342759 chr3:160939853 NMD3 -0.54 -7.86 -0.44 9.41e-14 Parkinson's disease; CESC cis rs6714710 0.603 rs35424768 chr2:98395653 A/C cg26665480 chr2:98280029 ACTR1B 0.57 8.03 0.44 3.3e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs858239 1.000 rs858239 chr7:23286315 G/A cg23682824 chr7:23144976 KLHL7 0.41 5.44 0.32 1.2e-7 Cerebrospinal fluid biomarker levels; CESC cis rs929596 0.755 rs4148324 chr2:234672722 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.67 -8.89 -0.48 9.89e-17 Total bilirubin levels in HIV-1 infection; CESC cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg08917208 chr2:24149416 ATAD2B 0.66 6.32 0.36 1.09e-9 Lymphocyte counts; CESC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.27 0.31 2.88e-7 Tonsillectomy; CESC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.96 -0.34 8.13e-9 Total body bone mineral density; CESC cis rs7927771 0.965 rs12787112 chr11:47687147 A/G cg05585544 chr11:47624801 NA -0.5 -7.88 -0.44 8.28e-14 Subjective well-being; CESC cis rs1059312 1.000 rs7135987 chr12:129280117 G/A cg09035930 chr12:129282057 SLC15A4 0.78 11.03 0.56 1.54e-23 Systemic lupus erythematosus; CESC cis rs965469 0.948 rs6051769 chr20:3326438 G/A cg25506879 chr20:3388711 C20orf194 -0.55 -5.72 -0.33 2.93e-8 IFN-related cytopenia; CESC cis rs17376456 0.877 rs10064520 chr5:93427358 T/C cg21475434 chr5:93447410 FAM172A 0.88 7.67 0.43 3.29e-13 Diabetic retinopathy; CESC cis rs926392 0.640 rs2867899 chr20:37694622 C/A cg16355469 chr20:37678765 NA 0.52 5.72 0.33 2.81e-8 Dialysis-related mortality; CESC cis rs9915657 0.870 rs35271702 chr17:70140516 G/A cg09344028 chr17:70110421 NA 0.34 6.01 0.35 6.13e-9 Thyroid hormone levels; CESC cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg12292205 chr6:26970375 C6orf41 -0.53 -5.76 -0.33 2.33e-8 Intelligence (multi-trait analysis); CESC cis rs17376456 0.877 rs7701011 chr5:93311456 G/A cg25358565 chr5:93447407 FAM172A 1.07 10.61 0.55 3.7e-22 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04105453 chr2:27440337 CAD 0.57 6.85 0.39 5.21e-11 Gut microbiome composition (summer); CESC cis rs7937682 0.855 rs539553 chr11:111477333 C/T cg22437258 chr11:111473054 SIK2 0.71 9.43 0.5 2.2e-18 Primary sclerosing cholangitis; CESC cis rs7692995 1.000 rs7670435 chr4:17962260 G/A cg08925142 chr4:18023851 LCORL -0.45 -5.13 -0.3 5.66e-7 Height; CESC cis rs2637266 0.600 rs10824427 chr10:78344387 A/G cg18941641 chr10:78392320 NA -0.34 -5.3 -0.31 2.42e-7 Pulmonary function; CESC cis rs8141529 0.764 rs5762824 chr22:29222930 C/T cg02153584 chr22:29168773 CCDC117 0.65 9.21 0.49 1.03e-17 Lymphocyte counts; CESC cis rs2859741 0.608 rs532719 chr1:37477380 C/T cg09363841 chr1:37513479 NA 0.53 7.44 0.42 1.4e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18070621 chr17:79869449 PCYT2 0.6 6.71 0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs3015497 0.537 rs2934664 chr14:51155485 C/A cg26011998 chr14:51135199 SAV1 -0.54 -6.13 -0.35 3.13e-9 Mean platelet volume; CESC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -7.23 -0.41 5.3e-12 Alzheimer's disease; CESC cis rs9322193 0.607 rs915140 chr6:150220810 C/T cg01145232 chr6:150245071 RAET1G 0.52 6.57 0.37 2.72e-10 Lung cancer; CESC cis rs56046484 0.956 rs34105012 chr15:85591686 C/G cg08123816 chr15:85640762 PDE8A -0.5 -6.21 -0.36 2.05e-9 Testicular germ cell tumor; CESC cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.78 8.92 0.48 7.63e-17 Alzheimer's disease; CESC cis rs17125944 0.615 rs2357944 chr14:53305573 T/G cg00686598 chr14:53173677 PSMC6 -0.65 -5.6 -0.33 5.48e-8 Alzheimer's disease (late onset); CESC cis rs9790314 0.905 rs6789388 chr3:160970437 G/A cg03342759 chr3:160939853 NMD3 -0.47 -6.29 -0.36 1.29e-9 Morning vs. evening chronotype; CESC cis rs13191362 0.935 rs34540135 chr6:162934351 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.69 5.97 0.34 7.56e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12900413 0.687 rs72754547 chr15:90308166 A/C cg24249390 chr15:90295951 MESP1 -0.39 -5.47 -0.32 1.03e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs10870270 1.000 rs10781564 chr10:133757922 A/G cg17892150 chr10:133769511 PPP2R2D -0.84 -12.45 -0.61 2.47e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg26408565 chr15:76604113 ETFA -0.4 -5.96 -0.34 8.16e-9 Blood metabolite levels; CESC cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg18016565 chr1:150552671 MCL1 -0.35 -5.82 -0.34 1.69e-8 Tonsillectomy; CESC cis rs3093024 0.967 rs1571878 chr6:167540842 C/T cg23791538 chr6:167370224 RNASET2 0.42 5.19 0.3 4.27e-7 Rheumatoid arthritis; CESC cis rs6982240 0.514 rs10095322 chr8:142262327 A/G cg00131261 chr8:142287264 NA -0.53 -7.26 -0.41 4.25e-12 Tonsillectomy; CESC cis rs3015497 0.594 rs35637875 chr14:51132533 T/G cg09863266 chr14:51125203 SAV1 -0.36 -5.61 -0.33 5.1e-8 Mean platelet volume; CESC cis rs3204270 0.639 rs6565620 chr17:79658100 C/T cg18367735 chr17:79674897 NA 0.66 5.7 0.33 3.22e-8 Dental caries; CESC cis rs6424115 0.830 rs6672157 chr1:24198840 C/G cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC cis rs56046484 0.956 rs34919315 chr15:85631906 C/A cg08123816 chr15:85640762 PDE8A -0.5 -6.02 -0.35 5.81e-9 Testicular germ cell tumor; CESC cis rs1983891 1.000 rs2104506 chr6:41533579 C/A cg20194872 chr6:41519635 FOXP4 0.55 7.85 0.43 1.05e-13 Prostate cancer; CESC cis rs2439831 1.000 rs1814538 chr15:43759774 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.82 -11.94 -0.59 1.43e-26 Lung cancer in ever smokers; CESC cis rs8114671 0.967 rs2065978 chr20:33767291 C/T cg24642439 chr20:33292090 TP53INP2 0.44 5.26 0.31 2.95e-7 Height; CESC cis rs6963495 0.818 rs73190163 chr7:105157294 G/T cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC trans rs61931739 0.534 rs2087128 chr12:34000173 T/C cg26384229 chr12:38710491 ALG10B 0.47 6.51 0.37 3.8e-10 Morning vs. evening chronotype; CESC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg22823121 chr1:150693482 HORMAD1 0.42 5.81 0.34 1.81e-8 Melanoma; CESC cis rs4906332 0.834 rs12882130 chr14:103878774 C/G cg09975044 chr14:104007538 NA 0.38 5.12 0.3 5.93e-7 Coronary artery disease; CESC cis rs9581857 0.556 rs9581861 chr13:28039991 C/T cg22138327 chr13:27999177 GTF3A 0.64 7.1 0.4 1.16e-11 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs8060686 0.641 rs7199588 chr16:68224582 C/T cg26727032 chr16:67993705 SLC12A4 -0.5 -6.03 -0.35 5.36e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs7824557 0.527 rs4631425 chr8:11239054 C/T cg21775007 chr8:11205619 TDH -0.52 -7.89 -0.44 7.81e-14 Retinal vascular caliber; CESC cis rs7605827 0.897 rs763355 chr2:15518838 A/G cg19274914 chr2:15703543 NA 0.35 6.11 0.35 3.61e-9 Educational attainment (years of education); CESC cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg22875332 chr1:76189707 ACADM 0.66 7.84 0.43 1.1e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2228479 0.702 rs2074963 chr16:89877269 T/C cg00800038 chr16:89945340 TCF25 -0.89 -6.88 -0.39 4.22e-11 Skin colour saturation; CESC cis rs6502050 0.835 rs8066284 chr17:80127825 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.61e-10 Life satisfaction; CESC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg02038168 chr22:39784481 NA -0.62 -7.66 -0.43 3.4e-13 Intelligence (multi-trait analysis); CESC cis rs76419734 0.510 rs28391170 chr4:106629246 A/C cg24545054 chr4:106630052 GSTCD;INTS12 0.69 8.38 0.46 3.15e-15 Post bronchodilator FEV1; CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg26354017 chr1:205819088 PM20D1 -0.71 -11.53 -0.58 3.5e-25 Monocyte percentage of white cells; CESC cis rs17376456 0.825 rs35496867 chr5:93220400 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.08 0.3 7.29e-7 Diabetic retinopathy; CESC cis rs807669 0.548 rs5748028 chr22:19172281 G/A cg02655711 chr22:19163373 SLC25A1 0.76 11.75 0.59 6.14e-26 Metabolite levels; CESC trans rs208520 0.909 rs9453672 chr6:66991431 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 8.51 0.46 1.34e-15 Exhaled nitric oxide output; CESC cis rs9858542 0.953 rs12330269 chr3:49513910 G/A cg03060546 chr3:49711283 APEH -0.54 -6.12 -0.35 3.44e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs67478160 0.619 rs10083367 chr14:104314183 C/G cg01849466 chr14:104193079 ZFYVE21 0.5 6.84 0.39 5.43e-11 Schizophrenia; CESC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 12.81 0.62 1.44e-29 Platelet count; CESC cis rs8044868 0.530 rs2288002 chr16:72057282 A/G cg01557791 chr16:72042693 DHODH -0.46 -6.39 -0.37 7.31e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7703051 0.901 rs4704221 chr5:74759183 A/T cg03227963 chr5:74354835 NA -0.29 -5.26 -0.31 2.92e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs7618501 1.000 rs7649348 chr3:49772375 G/A cg24308560 chr3:49941425 MST1R 0.5 6.81 0.39 6.38e-11 Intelligence (multi-trait analysis); CESC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC trans rs3102460 0.618 rs3102461 chr1:244577289 C/T cg01977209 chr2:236293433 NA 0.47 6.18 0.35 2.38e-9 Obesity-related traits; CESC cis rs11098499 0.954 rs59866101 chr4:120296591 T/G cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs2299587 0.527 rs7843715 chr8:17733526 C/A cg08627089 chr8:17753878 FGL1 -0.39 -5.63 -0.33 4.53e-8 Economic and political preferences; CESC cis rs9611565 0.569 rs188057 chr22:41822305 T/G cg06481639 chr22:41940642 POLR3H 0.64 6.41 0.37 6.73e-10 Vitiligo; CESC cis rs6540556 0.954 rs10489342 chr1:209935778 A/G cg05527609 chr1:210001259 C1orf107 -0.44 -5.55 -0.32 6.87e-8 Red blood cell count; CESC cis rs17253792 0.915 rs28537145 chr14:56179119 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.73 5.13 0.3 5.7e-7 Putamen volume; CESC trans rs7000551 0.725 rs2469756 chr8:22360423 G/A cg24804145 chr7:158144409 PTPRN2 -0.32 -6.07 -0.35 4.42e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs72781680 0.898 rs12612492 chr2:24093756 C/T cg20701182 chr2:24300061 SF3B14 0.63 5.83 0.34 1.58e-8 Lymphocyte counts; CESC cis rs7605827 0.930 rs4668900 chr2:15511740 T/C cg19274914 chr2:15703543 NA 0.32 5.58 0.32 5.95e-8 Educational attainment (years of education); CESC cis rs6964587 1.000 rs13231578 chr7:91663266 C/T cg17063962 chr7:91808500 NA 0.55 7.35 0.41 2.47e-12 Breast cancer; CESC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg02725872 chr8:58115012 NA -0.37 -5.91 -0.34 1.06e-8 Developmental language disorder (linguistic errors); CESC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs7264396 0.667 rs224368 chr20:34070380 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -5.26 -0.31 2.97e-7 Total cholesterol levels; CESC trans rs629535 0.767 rs62513418 chr8:70114376 G/T cg21567404 chr3:27674614 NA -0.88 -10.26 -0.53 5.22e-21 Dupuytren's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13846682 chr14:34931391 C14orf147 -0.47 -6.69 -0.38 1.3100000000000001e-10 Ulcerative colitis; CESC cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg14061069 chr19:46274453 DMPK -0.38 -5.44 -0.32 1.23e-7 Coronary artery disease; CESC cis rs7116495 0.609 rs7111379 chr11:71826319 C/T cg07596299 chr11:71824057 C11orf51 0.79 5.03 0.3 9.06e-7 Severe influenza A (H1N1) infection; CESC cis rs9303401 0.612 rs2526370 chr17:56487636 G/C cg12560992 chr17:57184187 TRIM37 0.6 7.93 0.44 6.07e-14 Cognitive test performance; CESC cis rs8017423 0.967 rs11624725 chr14:90713609 G/T cg14092571 chr14:90743983 NA 0.58 8.73 0.47 2.84e-16 Mortality in heart failure; CESC cis rs1005277 0.540 rs1814077 chr10:37992018 G/C cg25517755 chr10:38738941 LOC399744 -0.41 -5.24 -0.31 3.25e-7 Extrinsic epigenetic age acceleration; CESC cis rs34734847 0.842 rs7308648 chr12:121144144 C/G cg26008908 chr12:120799332 MSI1 0.36 5.5 0.32 8.79e-8 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03353863 chr19:52618714 ZNF616 -0.74 -8.15 -0.45 1.43e-14 Gut microbiome composition (summer); CESC cis rs11112613 0.713 rs73184083 chr12:105952593 T/A cg03607813 chr12:105948248 NA 0.59 7.41 0.41 1.75e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC trans rs9858542 0.953 rs9824092 chr3:49674147 C/G cg21659725 chr3:3221576 CRBN -0.52 -6.3 -0.36 1.21e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2302190 0.882 rs2270098 chr17:56572081 C/T cg25885038 chr17:56607967 SEPT4 -0.41 -5.58 -0.32 5.79e-8 Vitamin D levels; CESC trans rs4716602 0.596 rs10244786 chr7:156157989 C/T cg07175507 chr18:77160758 NFATC1 -0.45 -6.17 -0.35 2.52e-9 Anti-saccade response; CESC cis rs1784581 0.588 rs1784583 chr6:162410132 C/T cg17173639 chr6:162384350 PARK2 -0.54 -8.2 -0.45 1.04e-14 Itch intensity from mosquito bite; CESC cis rs1178968 1.000 rs1178959 chr7:72777093 T/C cg25889504 chr7:72793014 NA 0.51 5.42 0.32 1.36e-7 Triglyceride levels; CESC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg09365446 chr1:150670422 GOLPH3L 0.38 5.13 0.3 5.52e-7 Melanoma; CESC cis rs9916302 0.706 rs11655972 chr17:37407072 C/T cg07936489 chr17:37558343 FBXL20 -0.95 -11.1 -0.56 9.49e-24 Glomerular filtration rate (creatinine); CESC cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg03060546 chr3:49711283 APEH 0.54 7.46 0.42 1.23e-12 Menarche (age at onset); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg23731836 chr8:29120779 KIF13B -0.42 -6.33 -0.36 1.01e-9 Vertical cup-disc ratio; CESC cis rs9487051 0.700 rs7773815 chr6:109602343 A/C cg21918786 chr6:109611834 NA -0.39 -5.7 -0.33 3.22e-8 Reticulocyte fraction of red cells; CESC trans rs7922314 0.571 rs16918001 chr10:64749870 G/A cg06935979 chr1:232941706 KIAA1383 -0.62 -6.01 -0.35 5.98e-9 Cutaneous psoriasis; CESC cis rs8180040 0.545 rs9311403 chr3:47138878 T/C cg27129171 chr3:47204927 SETD2 0.66 9.84 0.52 1.1e-19 Colorectal cancer; CESC cis rs6088590 1.000 rs6087623 chr20:33317662 C/G cg08999081 chr20:33150536 PIGU 0.58 8.85 0.48 1.24e-16 Coronary artery disease; CESC cis rs1881797 1.000 rs12071797 chr1:247686871 A/G cg18198730 chr1:247681584 NA 0.59 7.76 0.43 1.84e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg12193833 chr17:30244370 NA 0.54 5.46 0.32 1.09e-7 Hip circumference adjusted for BMI; CESC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg00745463 chr17:30367425 LRRC37B -0.63 -6.18 -0.36 2.36e-9 Hip circumference adjusted for BMI; CESC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg21144161 chr5:423903 AHRR 0.37 6.09 0.35 3.9e-9 Cystic fibrosis severity; CESC cis rs2282802 0.685 rs11748023 chr5:139558584 C/T cg26211634 chr5:139558579 C5orf32 -0.49 -7.05 -0.4 1.55e-11 Intelligence (multi-trait analysis); CESC trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.39 -0.46 2.99e-15 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24780086 chr5:14713043 ANKH -0.53 -6.3 -0.36 1.26e-9 Gut microbiome composition (summer); CESC cis rs7520050 0.778 rs3014218 chr1:46026328 A/C cg03146154 chr1:46216737 IPP -0.5 -6.49 -0.37 4.16e-10 Red blood cell count;Reticulocyte count; CESC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs9815354 0.951 rs73830511 chr3:41864643 G/T cg03022575 chr3:42003672 ULK4 0.49 5.52 0.32 7.99e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg04234412 chr22:24373322 LOC391322 0.53 7.67 0.43 3.29e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs66887589 0.934 rs2389873 chr4:120554714 A/G cg09307838 chr4:120376055 NA -0.44 -5.85 -0.34 1.42e-8 Diastolic blood pressure; CESC cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg25019033 chr10:957182 NA -0.56 -6.27 -0.36 1.43e-9 Eosinophil percentage of granulocytes; CESC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg25566285 chr7:158114605 PTPRN2 0.49 8.13 0.45 1.64e-14 Calcium levels; CESC trans rs1814175 0.645 rs1721996 chr11:49915527 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs11122272 0.735 rs2486735 chr1:231521778 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs4654899 0.865 rs10916910 chr1:21283192 G/T cg05370193 chr1:21551575 ECE1 0.43 6.36 0.36 8.92e-10 Superior frontal gyrus grey matter volume; CESC cis rs9549367 0.713 rs2476328 chr13:113829350 C/T cg00898013 chr13:113819073 PROZ 0.5 7.22 0.41 5.61e-12 Platelet distribution width; CESC cis rs9488822 0.702 rs10872141 chr6:116323246 C/A cg15226275 chr6:116381976 FRK 0.25 6.22 0.36 1.94e-9 Cholesterol, total;LDL cholesterol; CESC cis rs798766 1.000 rs798767 chr4:1734281 A/G cg10756475 chr4:1757242 NA 0.45 5.81 0.34 1.82e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs7572263 0.724 rs6710543 chr2:209050447 G/A cg23998903 chr2:209048830 C2orf80 -0.39 -5.14 -0.3 5.4e-7 Glioma;Non-glioblastoma glioma; CESC trans rs1003719 0.715 rs762139 chr21:38568475 A/T cg00630453 chr20:2821369 FAM113A;VPS16 -0.44 -6.18 -0.35 2.45e-9 Eye color traits; CESC cis rs9902453 0.845 rs7222842 chr17:28246943 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.2 0.45 1.04e-14 Coffee consumption (cups per day); CESC cis rs10191773 0.589 rs11691239 chr2:112950600 A/C cg24977338 chr2:113188963 RGPD8;RGPD5 0.65 6.77 0.38 8.03e-11 Yeast infection; CESC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg13206674 chr6:150067644 NUP43 0.43 6.27 0.36 1.44e-9 Lung cancer; CESC cis rs11098499 0.955 rs7684942 chr4:120162201 C/T cg09307838 chr4:120376055 NA 0.86 11.44 0.58 6.63e-25 Corneal astigmatism; CESC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg26314531 chr2:26401878 FAM59B 0.83 9.05 0.49 3.21e-17 Gut microbiome composition (summer); CESC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg25985355 chr7:65971099 NA -0.31 -5.14 -0.3 5.25e-7 Aortic root size; CESC cis rs3750965 1.000 rs7937006 chr11:68843932 C/T cg01403660 chr11:68851641 TPCN2 0.42 5.49 0.32 9.39e-8 Hair color; CESC cis rs9796 0.689 rs9888718 chr15:41446254 T/G cg12426344 chr15:41135900 SPINT1 -0.24 -5.31 -0.31 2.32e-7 Menopause (age at onset); CESC trans rs2727020 0.521 rs7930855 chr11:49521660 C/T cg15704280 chr7:45808275 SEPT13 0.82 9.96 0.52 4.58e-20 Coronary artery disease; CESC cis rs79976124 0.800 rs10944857 chr6:66637078 C/T cg07460842 chr6:66804631 NA 0.68 7.86 0.44 9.39e-14 Type 2 diabetes; CESC cis rs8072100 0.817 rs9912101 chr17:45547078 A/G cg08085267 chr17:45401833 C17orf57 -0.58 -7.72 -0.43 2.36e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9583531 0.600 rs4773240 chr13:111360585 G/A cg15841412 chr13:111365552 ING1 0.52 6.74 0.38 1.01e-10 Coronary artery disease; CESC cis rs4972806 0.849 rs1542180 chr2:177028767 C/T cg13092806 chr2:177043255 NA 0.47 7.05 0.4 1.55e-11 IgG glycosylation; CESC cis rs933688 1.000 rs12188467 chr5:90765632 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.04 13.57 0.64 3.29e-32 Smoking behavior; CESC cis rs9583531 0.657 rs9521915 chr13:111384528 C/T cg24331049 chr13:111365604 ING1 0.72 10.24 0.53 5.77e-21 Coronary artery disease; CESC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg08736216 chr1:53307985 ZYG11A 0.42 7.11 0.4 1.06e-11 Monocyte count; CESC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg17911788 chr17:44343683 NA -0.6 -8.07 -0.44 2.39e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4642101 0.765 rs9872103 chr3:12827452 G/T cg24848339 chr3:12840334 CAND2 0.35 5.37 0.31 1.73e-7 QRS complex (12-leadsum); CESC cis rs7208859 0.673 rs12949860 chr17:29223032 A/G cg19761014 chr17:28927070 LRRC37B2 0.63 5.29 0.31 2.56e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.33 -0.36 1.04e-9 Developmental language disorder (linguistic errors); CESC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg18876405 chr7:65276391 NA 0.72 9.87 0.52 9.33e-20 Aortic root size; CESC cis rs3733585 0.605 rs4697926 chr4:10124567 G/T cg05927159 chr4:10118984 WDR1 -0.36 -5.25 -0.31 3.1e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg01988459 chr11:68622903 NA -0.41 -5.34 -0.31 2.05e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg05255149 chr17:80675120 FN3KRP 0.47 5.46 0.32 1.09e-7 Breast cancer; CESC cis rs3020736 0.500 rs6002623 chr22:42513761 G/A cg15557168 chr22:42548783 NA 0.45 6.51 0.37 3.78e-10 Autism spectrum disorder or schizophrenia; CESC cis rs4888262 0.545 rs8050624 chr16:74686690 A/G cg01733217 chr16:74700730 RFWD3 -0.92 -12.53 -0.61 1.35e-28 Testicular germ cell tumor; CESC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg09177884 chr7:1199841 ZFAND2A -0.43 -5.38 -0.31 1.67e-7 Longevity;Endometriosis; CESC cis rs977987 0.778 rs7203157 chr16:75417920 T/C cg03315344 chr16:75512273 CHST6 0.4 5.72 0.33 2.93e-8 Dupuytren's disease; CESC cis rs910316 0.967 rs175451 chr14:75589729 C/T cg08847533 chr14:75593920 NEK9 -0.95 -17.75 -0.74 5.29e-47 Height; CESC cis rs7640424 0.721 rs326356 chr3:107824563 C/T cg09227934 chr3:107805635 CD47 -0.38 -5.35 -0.31 1.87e-7 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08128925 chr19:11141458 SMARCA4 0.43 6.29 0.36 1.33e-9 Fibrinogen levels; CESC cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg18225595 chr11:63971243 STIP1 -0.5 -6.59 -0.38 2.31e-10 Platelet count; CESC cis rs9399137 0.507 rs13209780 chr6:135344795 G/C cg22676075 chr6:135203613 NA 0.53 7.22 0.41 5.6e-12 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.39 -0.37 7.54e-10 Total body bone mineral density; CESC cis rs4629710 0.592 rs1885641 chr6:131553986 A/G cg12606694 chr6:131520996 AKAP7 0.49 6.04 0.35 5.19e-9 Multiple myeloma (IgH translocation); CESC cis rs7945705 0.783 rs11042125 chr11:8938049 A/T cg09997546 chr11:8931473 C11orf17;ST5 -0.39 -6.41 -0.37 6.76e-10 Hemoglobin concentration; CESC trans rs2755237 0.519 rs80070740 chr13:41137784 G/A cg02923264 chr22:30901647 SEC14L4 0.75 6.16 0.35 2.66e-9 Central corneal thickness; CESC cis rs4835473 0.897 rs35599924 chr4:144901755 T/C cg25736465 chr4:144833511 NA 0.41 6.2 0.36 2.14e-9 Immature fraction of reticulocytes; CESC cis rs7107174 1.000 rs58235466 chr11:78030886 T/C cg02023728 chr11:77925099 USP35 0.38 5.52 0.32 8.09e-8 Testicular germ cell tumor; CESC cis rs2115536 0.640 rs934134 chr15:80168218 T/C cg11839771 chr15:80205821 ST20 -0.39 -5.65 -0.33 4.16e-8 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs1670533 0.932 rs4690214 chr4:1054636 T/C cg27284194 chr4:1044797 NA 0.46 5.85 0.34 1.42e-8 Recombination rate (females); CESC cis rs7246657 1.000 rs8110011 chr19:37745813 G/T cg23950597 chr19:37808831 NA -0.61 -6.37 -0.36 8.38e-10 Coronary artery calcification; CESC cis rs1568889 0.838 rs10767708 chr11:28294847 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 13.65 0.64 1.68e-32 Bipolar disorder; CESC cis rs1499972 0.887 rs1499970 chr3:117692767 G/A cg07612923 chr3:117604196 NA -0.86 -7.23 -0.41 5.17e-12 Schizophrenia; CESC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -7.32 -0.41 3e-12 Developmental language disorder (linguistic errors); CESC cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.5 -8.41 -0.46 2.54e-15 Monocyte percentage of white cells; CESC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg24503407 chr1:205819492 PM20D1 0.47 6.9 0.39 3.81e-11 Menarche (age at onset); CESC cis rs9916302 0.904 rs2338755 chr17:37419317 C/T cg15445000 chr17:37608096 MED1 -0.4 -6.69 -0.38 1.3e-10 Glomerular filtration rate (creatinine); CESC cis rs854765 0.583 rs9913724 chr17:17819101 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.56 7.99 0.44 4.08e-14 Total body bone mineral density; CESC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg08109568 chr15:31115862 NA -0.6 -8.04 -0.44 3.01e-14 Huntington's disease progression; CESC cis rs60843830 1.000 rs3791223 chr2:222336 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.87 11.47 0.58 5.31e-25 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs67478160 0.595 rs8022783 chr14:104245573 T/C cg01849466 chr14:104193079 ZFYVE21 -0.52 -7.18 -0.4 7.16e-12 Schizophrenia; CESC cis rs10927875 1.000 rs4307563 chr1:16313788 C/T cg22431228 chr1:16359049 CLCNKA 0.37 5.73 0.33 2.68e-8 Dilated cardiomyopathy; CESC cis rs7635838 0.523 rs9873503 chr3:11396100 T/C cg00170343 chr3:11313890 ATG7 0.47 6.56 0.37 2.77e-10 HDL cholesterol; CESC cis rs17431357 1.000 rs73230306 chr12:120985336 A/G cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg00033643 chr7:134001901 SLC35B4 0.44 5.6 0.33 5.4e-8 Mean platelet volume; CESC cis rs9796 0.576 rs13329511 chr15:41299121 T/C cg18705301 chr15:41695430 NDUFAF1 -0.59 -8.23 -0.45 8.42e-15 Menopause (age at onset); CESC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg07507251 chr3:52567010 NT5DC2 0.44 7.42 0.41 1.62e-12 Bipolar disorder; CESC cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg26597838 chr10:835615 NA 1.18 11.37 0.57 1.12e-24 Eosinophil percentage of granulocytes; CESC cis rs7089973 0.604 rs1924034 chr10:116578539 C/T cg23260525 chr10:116636907 FAM160B1 0.39 7.37 0.41 2.14e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs76878669 0.519 rs10791869 chr11:66117113 C/T cg18002602 chr11:66138449 SLC29A2 -0.42 -6.96 -0.39 2.67e-11 Educational attainment (years of education); CESC cis rs12479064 0.724 rs10496336 chr2:99996165 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -7.81 -0.43 1.3e-13 Chronic sinus infection; CESC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg18876405 chr7:65276391 NA -0.59 -7.9 -0.44 7.25e-14 Aortic root size; CESC cis rs910316 0.967 rs119076 chr14:75572419 G/T cg08847533 chr14:75593920 NEK9 -0.95 -17.87 -0.74 2.07e-47 Height; CESC cis rs950776 0.714 rs660652 chr15:78887832 A/G cg06917634 chr15:78832804 PSMA4 -0.52 -6.21 -0.36 2.09e-9 Sudden cardiac arrest; CESC cis rs909002 0.925 rs4949455 chr1:32114793 C/T cg13919466 chr1:32135498 COL16A1 -0.47 -8.34 -0.46 4e-15 Intelligence (multi-trait analysis); CESC cis rs4076764 1.000 rs7525643 chr1:163426283 G/A cg24596788 chr1:163392923 NA -0.47 -6.87 -0.39 4.47e-11 Motion sickness; CESC cis rs9323205 1.000 rs12589519 chr14:51596684 C/G cg23942311 chr14:51606299 NA -0.47 -5.97 -0.34 7.59e-9 Cancer; CESC cis rs4843747 0.671 rs13334603 chr16:88116016 T/C cg17633681 chr16:88106987 BANP 0.74 9.91 0.52 7e-20 Menopause (age at onset); CESC cis rs2932538 0.961 rs4838960 chr1:113163632 G/T cg22162597 chr1:113214053 CAPZA1 -0.49 -6.48 -0.37 4.57e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC trans rs7615952 0.641 rs12488180 chr3:125782236 C/T cg07211511 chr3:129823064 LOC729375 -0.57 -6.73 -0.38 1.03e-10 Blood pressure (smoking interaction); CESC cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg06212747 chr3:49208901 KLHDC8B 0.73 9.9 0.52 7e-20 Parkinson's disease; CESC cis rs12911832 1.000 rs4774310 chr15:58985164 T/G cg05156742 chr15:59063176 FAM63B 0.5 6.02 0.35 5.84e-9 Schizophrenia; CESC cis rs7605827 0.866 rs2287275 chr2:15658828 C/T cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.65e-10 Educational attainment (years of education); CESC cis rs2066819 1.000 rs117779516 chr12:56750872 G/C cg26734620 chr12:56694298 CS 0.98 5.68 0.33 3.49e-8 Psoriasis vulgaris; CESC trans rs11039798 0.588 rs11039782 chr11:48524785 A/G cg15704280 chr7:45808275 SEPT13 0.65 6.56 0.37 2.84e-10 Axial length; CESC cis rs11209002 0.524 rs982131 chr1:67542360 T/C cg02640540 chr1:67518911 SLC35D1 0.47 5.31 0.31 2.28e-7 Crohn's disease; CESC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg25036284 chr2:26402008 FAM59B -0.64 -7.54 -0.42 7.71e-13 Gut microbiome composition (summer); CESC cis rs6546550 0.901 rs6729760 chr2:70161032 C/T cg02498382 chr2:70120550 SNRNP27 -0.42 -7.29 -0.41 3.58e-12 Prevalent atrial fibrillation; CESC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg11890956 chr21:40555474 PSMG1 -0.98 -16.19 -0.71 1.87e-41 Cognitive function; CESC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.81 0.39 6.36e-11 Bipolar disorder; CESC cis rs2479724 0.818 rs9357369 chr6:41818202 A/C cg17623882 chr6:41773611 USP49 -0.41 -6.04 -0.35 5.2e-9 Menarche (age at onset); CESC cis rs6484504 0.532 rs11031330 chr11:31275073 G/A cg14844989 chr11:31128820 NA -0.37 -5.27 -0.31 2.89e-7 Red blood cell count; CESC cis rs6813479 0.523 rs2926564 chr4:137744172 C/T cg16185213 chr4:137733633 NA 0.37 5.05 0.3 8.19e-7 Longevity; CESC cis rs12900413 0.687 rs62023459 chr15:90308231 A/T cg24249390 chr15:90295951 MESP1 -0.39 -5.47 -0.32 1.03e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs5743618 0.537 rs11096957 chr4:38776491 A/C cg02016764 chr4:38805732 TLR1 -0.33 -5.11 -0.3 6.31e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg04450456 chr4:17643702 FAM184B 0.4 5.78 0.33 2.13e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs67311347 0.544 rs13062243 chr3:40336789 G/A cg09455208 chr3:40491958 NA 0.37 6.51 0.37 3.82e-10 Renal cell carcinoma; CESC cis rs9300255 0.602 rs1727294 chr12:123616514 A/G cg19016782 chr12:123741754 C12orf65 -0.4 -5.6 -0.33 5.32e-8 Neutrophil percentage of white cells; CESC cis rs10779751 0.770 rs1057079 chr1:11205058 A/G cg08854313 chr1:11322531 MTOR -0.82 -11.67 -0.58 1.18e-25 Body mass index; CESC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg04317338 chr11:64019027 PLCB3 0.86 8.93 0.48 7.13e-17 Attention deficit hyperactivity disorder; CESC cis rs1546924 0.669 rs197439 chr1:112280990 A/G cg23955903 chr1:112298873 DDX20;C1orf183 0.39 5.11 0.3 6.04e-7 Body mass index; CESC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg11890956 chr21:40555474 PSMG1 1.13 19.51 0.77 3.69e-53 Cognitive function; CESC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg22974920 chr21:40686053 BRWD1 -0.42 -5.21 -0.3 3.84e-7 Cognitive function; CESC cis rs7845219 0.525 rs3019175 chr8:95949013 G/A cg09323728 chr8:95962352 TP53INP1 -0.3 -5.7 -0.33 3.21e-8 Type 2 diabetes; CESC cis rs2425143 0.915 rs6060597 chr20:34370100 G/A cg23207816 chr20:34252616 CPNE1;RBM12 -0.72 -6.67 -0.38 1.52e-10 Blood protein levels; CESC cis rs6754311 0.509 rs12616520 chr2:136516748 A/T cg07169764 chr2:136633963 MCM6 -0.73 -9.25 -0.49 7.59e-18 Mosquito bite size; CESC cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg05457628 chr5:178986728 RUFY1 0.51 7.68 0.43 3.09e-13 Lung cancer; CESC cis rs1163251 0.869 rs629735 chr1:120206932 G/T cg19096424 chr1:120255104 PHGDH -0.42 -5.05 -0.3 8.42e-7 Blood metabolite levels; CESC cis rs10129255 1.000 rs10134517 chr14:107173745 T/C cg23076370 chr14:107095027 NA -0.43 -5.28 -0.31 2.64e-7 Kawasaki disease; CESC cis rs17376456 0.825 rs10078941 chr5:93279029 C/T cg21475434 chr5:93447410 FAM172A 0.74 6.16 0.35 2.7e-9 Diabetic retinopathy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25345767 chr1:226070210 TMEM63A -0.4 -6.0 -0.35 6.38e-9 Gambling; CESC cis rs4253772 0.592 rs1807600 chr22:46644640 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 6.81 0.39 6.68e-11 LDL cholesterol;Cholesterol, total; CESC cis rs208520 0.955 rs28684412 chr6:66979430 A/C cg07460842 chr6:66804631 NA 0.88 10.14 0.53 1.22e-20 Exhaled nitric oxide output; CESC cis rs10949834 0.824 rs13236108 chr7:73521113 A/G cg07137043 chr7:73588983 EIF4H -0.65 -5.72 -0.33 2.92e-8 Verbal memory performance (residualized delayed recall change); CESC cis rs3741404 0.757 rs2282492 chr11:63918589 A/G cg18225595 chr11:63971243 STIP1 0.67 9.15 0.49 1.57e-17 Platelet count; CESC cis rs57221529 0.766 rs12522140 chr5:587261 C/A cg16447950 chr5:562315 NA -0.62 -6.52 -0.37 3.51e-10 Lung disease severity in cystic fibrosis; CESC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg03609598 chr5:56110824 MAP3K1 -0.51 -5.54 -0.32 7.13e-8 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03990588 chr2:85826175 TMEM150A -0.51 -6.03 -0.35 5.56e-9 Gut microbiome composition (summer); CESC cis rs3892630 0.878 rs1559177 chr19:33210646 A/G cg13157960 chr19:33183277 NUDT19 0.55 5.03 0.3 9e-7 Red blood cell traits; CESC cis rs4654899 0.865 rs12410467 chr1:21356055 G/A cg05370193 chr1:21551575 ECE1 0.43 6.22 0.36 1.97e-9 Superior frontal gyrus grey matter volume; CESC cis rs7845219 0.525 rs10956931 chr8:95930301 A/G cg13393036 chr8:95962371 TP53INP1 -0.38 -6.99 -0.39 2.28e-11 Type 2 diabetes; CESC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.49 -6.19 -0.36 2.33e-9 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07705912 chr1:154155363 TPM3 0.59 6.61 0.38 2.13e-10 Gut microbiome composition (summer); CESC trans rs1728785 1.000 rs864741 chr16:68576577 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs8018808 0.875 rs176781 chr14:77887681 C/T cg20045696 chr14:77926864 AHSA1 0.42 5.84 0.34 1.56e-8 Myeloid white cell count; CESC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.79 10.48 0.54 1.01e-21 Height; CESC cis rs3015497 0.646 rs3015492 chr14:51124743 G/A cg26011998 chr14:51135199 SAV1 -0.59 -6.86 -0.39 4.75e-11 Mean platelet volume; CESC trans rs10411161 0.702 rs10424202 chr19:52387297 G/A cg22319618 chr22:45562946 NUP50 -0.73 -7.14 -0.4 8.9e-12 Breast cancer; CESC cis rs12618769 0.597 rs4851133 chr2:99050519 T/C cg10123293 chr2:99228465 UNC50 0.41 5.42 0.32 1.31e-7 Bipolar disorder; CESC cis rs3738443 0.645 rs55768801 chr1:247362990 G/A cg07706540 chr1:247373924 NA -0.46 -5.45 -0.32 1.15e-7 Alcohol dependence; CESC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg11663144 chr21:46675770 NA -0.62 -9.59 -0.51 6.96e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg05340658 chr4:99064831 C4orf37 0.77 11.6 0.58 2.01e-25 Colonoscopy-negative controls vs population controls; CESC cis rs6432018 0.964 rs3791748 chr2:9729815 C/G cg23886495 chr2:9695866 ADAM17 0.43 5.08 0.3 7.05e-7 Heart rate variability traits; CESC cis rs12079745 0.793 rs12074492 chr1:169215363 C/G cg09363564 chr1:169337483 NME7;BLZF1 -1.01 -6.28 -0.36 1.36e-9 QT interval; CESC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg13628971 chr7:2884303 GNA12 0.61 7.71 0.43 2.56e-13 Height; CESC trans rs1814175 0.781 rs1851872 chr11:50009770 A/G cg15704280 chr7:45808275 SEPT13 -1.04 -21.07 -0.79 1.43e-58 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23434193 chr8:74884752 TCEB1 -0.43 -6.14 -0.35 3.03e-9 Gambling; CESC cis rs7680126 0.633 rs2868937 chr4:10303081 C/T cg11266682 chr4:10021025 SLC2A9 -0.45 -5.92 -0.34 9.91e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg18758796 chr5:131593413 PDLIM4 -0.38 -5.11 -0.3 6.09e-7 Breast cancer; CESC cis rs6429082 0.521 rs291390 chr1:235649678 T/C cg26050004 chr1:235667680 B3GALNT2 0.82 12.75 0.62 2.28e-29 Adiposity; CESC cis rs6912958 0.712 rs9444526 chr6:88326402 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.74 -0.38 1e-10 Monocyte percentage of white cells; CESC cis rs922692 0.773 rs2869861 chr15:79076744 A/G cg04896959 chr15:78267971 NA 0.35 5.1 0.3 6.61e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs60843830 1.000 rs2126129 chr2:212548 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.74 9.31 0.5 5.15e-18 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg17372223 chr3:52568218 NT5DC2 0.37 5.78 0.33 2.09e-8 Electroencephalogram traits; CESC cis rs155076 1.000 rs261369 chr13:21868420 C/A cg11317459 chr13:21872234 NA -1.09 -12.3 -0.6 8.03e-28 White matter hyperintensity burden; CESC cis rs524023 0.914 rs2360873 chr11:64391157 G/C cg07220939 chr11:64358617 SLC22A12 -0.36 -5.45 -0.32 1.17e-7 Urate levels in obese individuals; CESC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg06873352 chr17:61820015 STRADA 0.72 12.74 0.62 2.58e-29 Prudent dietary pattern; CESC cis rs9948 1.000 rs62152790 chr2:97478579 G/A cg01990225 chr2:97406019 LMAN2L -0.82 -5.83 -0.34 1.61e-8 Erectile dysfunction and prostate cancer treatment; CESC cis rs3820928 0.605 rs4675124 chr2:227802354 G/A cg11843606 chr2:227700838 RHBDD1 -0.55 -7.81 -0.43 1.34e-13 Pulmonary function; CESC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg04025307 chr7:1156635 C7orf50 0.48 7.76 0.43 1.89e-13 Longevity;Endometriosis; CESC cis rs12477438 0.520 rs7572660 chr2:99788582 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.72 0.69 8.39e-40 Chronic sinus infection; CESC cis rs3126085 0.515 rs11204984 chr1:152331987 T/C cg03465714 chr1:152285911 FLG 0.4 5.2 0.3 3.93e-7 Atopic dermatitis; CESC cis rs2952156 0.876 rs903501 chr17:37839493 T/C cg00129232 chr17:37814104 STARD3 -0.76 -10.17 -0.53 9.96e-21 Asthma; CESC cis rs7385804 0.796 rs10277087 chr7:100307538 C/G cg16850897 chr7:100343110 ZAN 0.5 6.95 0.39 2.8e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs10870270 1.000 rs10430617 chr10:133748889 T/C cg17892150 chr10:133769511 PPP2R2D -0.86 -12.58 -0.61 9.08e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg21285383 chr16:89894308 SPIRE2 0.29 5.27 0.31 2.87e-7 Vitiligo; CESC cis rs6540559 0.546 rs735693 chr1:210033988 A/C cg25204440 chr1:209979598 IRF6 0.58 5.67 0.33 3.77e-8 Cleft lip with or without cleft palate; CESC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.64 0.42 4.1e-13 Prudent dietary pattern; CESC cis rs6088813 0.890 rs6088817 chr20:33984976 T/C cg14752227 chr20:34000481 UQCC -0.4 -5.09 -0.3 6.76e-7 Height; CESC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg06558623 chr16:89946397 TCF25 -1.07 -9.01 -0.48 4.32e-17 Skin colour saturation; CESC cis rs6598955 0.671 rs11247884 chr1:26577338 C/T cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC cis rs3820068 0.608 rs10927836 chr1:16034368 G/C cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.64e-7 Systolic blood pressure; CESC cis rs67311347 0.544 rs6599088 chr3:40329288 T/C cg09455208 chr3:40491958 NA 0.35 6.24 0.36 1.68e-9 Renal cell carcinoma; CESC trans rs7824557 0.583 rs2263511 chr8:11233318 A/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.15 -0.35 2.78e-9 Retinal vascular caliber; CESC cis rs2040771 0.804 rs2073754 chr22:19221406 G/T cg17887427 chr22:19166691 SLC25A1 0.41 5.36 0.31 1.8e-7 Metabolite levels (small molecules and protein measures); CESC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg11366901 chr6:160182831 ACAT2 -0.59 -7.71 -0.43 2.53e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs2191566 0.576 rs402785 chr19:44492236 T/G cg20607764 chr19:44506953 ZNF230 0.44 5.57 0.32 6.29e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg07936489 chr17:37558343 FBXL20 0.81 11.81 0.59 3.83e-26 Glomerular filtration rate (creatinine); CESC cis rs9926296 0.581 rs2108838 chr16:89904426 A/G cg04287289 chr16:89883240 FANCA 0.69 9.04 0.49 3.44e-17 Vitiligo; CESC cis rs5753618 0.539 rs737888 chr22:31611549 A/G cg13145458 chr22:31556086 RNF185 0.48 5.4 0.31 1.51e-7 Colorectal cancer; CESC cis rs6594499 0.542 rs4530809 chr5:110462230 A/G cg04022379 chr5:110408740 TSLP 0.42 6.9 0.39 3.76e-11 Allergic disease (asthma, hay fever or eczema); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18800192 chr19:42388471 ARHGEF1 0.5 6.21 0.36 2.01e-9 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26678852 chr1:68297929 GNG12 -0.51 -6.38 -0.36 7.72e-10 Ulcerative colitis; CESC cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.09 0.3 6.9e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10242455 0.702 rs17854665 chr7:99050039 G/A cg09045935 chr12:6379348 NA 0.91 7.3 0.41 3.34e-12 Blood metabolite levels; CESC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Parkinson's disease; CESC cis rs7395581 0.918 rs10501321 chr11:47294626 A/G cg25783544 chr11:47291846 MADD 0.58 7.58 0.42 5.8e-13 HDL cholesterol; CESC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg24768116 chr2:27665128 KRTCAP3 -0.31 -5.9 -0.34 1.12e-8 Total body bone mineral density; CESC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg09323728 chr8:95962352 TP53INP1 -0.4 -8.68 -0.47 4.05e-16 Type 2 diabetes; CESC cis rs4948102 0.667 rs7811270 chr7:56139990 A/G cg09872392 chr7:56161020 PHKG1 -0.44 -7.22 -0.41 5.57e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs2637266 0.597 rs846622 chr10:78543005 G/A cg18941641 chr10:78392320 NA 0.41 7.76 0.43 1.81e-13 Pulmonary function; CESC cis rs34779708 0.931 rs7084196 chr10:35367161 T/C cg04310649 chr10:35416472 CREM -0.52 -6.4 -0.37 7.03e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs1451375 0.756 rs11761683 chr7:50542879 C/T cg14593290 chr7:50529359 DDC -0.4 -5.25 -0.31 3.15e-7 Malaria; CESC cis rs9393777 0.588 rs6456728 chr6:26477779 G/A cg12826209 chr6:26865740 GUSBL1 0.56 6.5 0.37 3.92e-10 Intelligence (multi-trait analysis); CESC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg06873352 chr17:61820015 STRADA 0.72 12.51 0.61 1.53e-28 Prudent dietary pattern; CESC cis rs2380220 0.810 rs66524640 chr6:95956566 T/C cg15832292 chr6:96025679 MANEA -0.64 -5.66 -0.33 3.83e-8 Behavioural disinhibition (generation interaction); CESC cis rs4268898 0.722 rs10445893 chr2:24407128 A/G cg06627628 chr2:24431161 ITSN2 0.54 7.29 0.41 3.54e-12 Asthma; CESC cis rs8018808 0.870 rs11159264 chr14:77937017 T/C cg20045696 chr14:77926864 AHSA1 0.47 6.65 0.38 1.7e-10 Myeloid white cell count; CESC cis rs72627123 0.867 rs8018226 chr14:74471377 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.8 5.77 0.33 2.2e-8 Morning vs. evening chronotype; CESC cis rs7223966 1.000 rs55868506 chr17:61851686 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.73 0.38 1.06e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs854765 0.583 rs8065563 chr17:17782404 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.55 7.51 0.42 9.05e-13 Total body bone mineral density; CESC cis rs6835098 0.509 rs2332655 chr4:174093002 A/G cg08422745 chr4:174089978 GALNT7 0.55 7.36 0.41 2.26e-12 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg12658694 chr1:38397304 INPP5B 0.79 12.32 0.6 6.98e-28 Coronary artery disease; CESC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg18099408 chr3:52552593 STAB1 -0.32 -5.24 -0.31 3.23e-7 Bipolar disorder; CESC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg09177884 chr7:1199841 ZFAND2A -0.51 -6.6 -0.38 2.17e-10 Longevity;Endometriosis; CESC cis rs1707322 1.000 rs4660903 chr1:46457601 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2276314 1.000 rs1789513 chr18:33545630 A/G cg19628046 chr18:33552617 C18orf21 -0.59 -6.64 -0.38 1.8e-10 Endometriosis;Drug-induced torsades de pointes; CESC cis rs2777491 1.000 rs2777491 chr15:41735710 T/G cg20272979 chr15:41787780 ITPKA 0.45 6.71 0.38 1.15e-10 Ulcerative colitis; CESC cis rs7208859 0.623 rs73271869 chr17:29152221 G/A cg19761014 chr17:28927070 LRRC37B2 0.74 6.03 0.35 5.43e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg10361922 chr17:40925790 VPS25 0.51 6.44 0.37 5.71e-10 Psoriatic arthritis; CESC cis rs1950626 0.623 rs61991083 chr14:101436435 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.69 9.23 0.49 8.76e-18 Pelvic organ prolapse (moderate/severe); CESC cis rs11853189 0.882 rs79052265 chr15:78556258 A/T cg22935921 chr15:78556834 DNAJA4 0.61 5.1 0.3 6.35e-7 Red cell distribution width; CESC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg06600287 chr1:53387719 ECHDC2 -0.31 -5.74 -0.33 2.64e-8 Monocyte count; CESC cis rs709400 0.628 rs2273700 chr14:103923414 A/G cg12935359 chr14:103987150 CKB -0.57 -8.42 -0.46 2.46e-15 Body mass index; CESC cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg17366294 chr4:99064904 C4orf37 0.62 8.88 0.48 1.03e-16 Colonoscopy-negative controls vs population controls; CESC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg22968622 chr17:43663579 NA -1.16 -16.1 -0.7 3.81e-41 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs722599 0.748 rs741096 chr14:75351487 A/G cg11812906 chr14:75593930 NEK9 -0.47 -5.68 -0.33 3.49e-8 IgG glycosylation; CESC cis rs35110281 0.506 rs13051661 chr21:45111518 A/T cg21573476 chr21:45109991 RRP1B -0.59 -8.71 -0.47 3.25e-16 Mean corpuscular volume; CESC cis rs7824557 0.602 rs35807737 chr8:11204411 C/G cg21775007 chr8:11205619 TDH 0.58 8.94 0.48 6.84e-17 Retinal vascular caliber; CESC cis rs11122272 0.735 rs2572263 chr1:231509408 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs4704187 0.687 rs6864485 chr5:74497984 T/C cg03227963 chr5:74354835 NA 0.28 5.18 0.3 4.33e-7 Response to amphetamines; CESC cis rs6912958 0.712 rs4587138 chr6:88356915 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.71 -0.38 1.19e-10 Monocyte percentage of white cells; CESC cis rs709400 0.663 rs2273703 chr14:103918029 C/G cg12935359 chr14:103987150 CKB -0.51 -7.51 -0.42 9.15e-13 Body mass index; CESC cis rs7666738 0.830 rs7696715 chr4:98938486 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4700695 0.719 rs36923 chr5:65464783 G/C cg21114390 chr5:65439923 SFRS12 -0.49 -5.92 -0.34 9.86e-9 Facial morphology (factor 19); CESC cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg21573476 chr21:45109991 RRP1B -0.54 -8.01 -0.44 3.73e-14 Mean corpuscular volume; CESC cis rs12142240 0.698 rs6703374 chr1:46862332 C/G cg00530320 chr1:46809349 NSUN4 0.6 8.27 0.45 6.54e-15 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03008165 chr11:77024667 NA -0.62 -7.31 -0.41 3.2e-12 Gut microbiome composition (summer); CESC cis rs3820068 0.581 rs6692461 chr1:15928449 A/G cg13390004 chr1:15929781 NA 0.34 5.45 0.32 1.13e-7 Systolic blood pressure; CESC cis rs881375 0.678 rs2269060 chr9:123683569 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.46 6.7 0.38 1.24e-10 Rheumatoid arthritis; CESC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg27170947 chr2:26402098 FAM59B -0.59 -6.88 -0.39 4.18e-11 Gut microbiome composition (summer); CESC cis rs367943 1.000 rs168365 chr5:112817984 G/A cg12552261 chr5:112820674 MCC -0.62 -7.78 -0.43 1.58e-13 Type 2 diabetes; CESC cis rs524281 0.773 rs7925123 chr11:65993213 G/C cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.38e-7 Electroencephalogram traits; CESC cis rs1801251 1.000 rs778166 chr2:233664097 A/T cg25237894 chr2:233734115 C2orf82 0.46 8.17 0.45 1.27e-14 Coronary artery disease; CESC cis rs7937682 0.889 rs490199 chr11:111487890 A/G cg22437258 chr11:111473054 SIK2 0.71 9.48 0.5 1.47e-18 Primary sclerosing cholangitis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08974500 chr6:170863287 PSMB1;TBP 0.48 6.74 0.38 9.75e-11 Systemic lupus erythematosus; CESC cis rs4472734 1.000 rs4072973 chr1:214628635 A/C cg00063699 chr1:214624242 PTPN14 -0.33 -5.08 -0.3 7.25e-7 Height; CESC cis rs11871801 0.918 rs36005199 chr17:40597555 A/G cg21433558 chr17:40837037 CNTNAP1 0.42 5.15 0.3 5.12e-7 Crohn's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24720361 chr12:57882021 MARS -0.52 -7.25 -0.41 4.66e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg05639522 chr1:247681581 NA 0.5 6.34 0.36 9.98e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs6690583 0.697 rs4907126 chr1:85523453 C/T cg22153463 chr1:85462885 MCOLN2 0.64 7.96 0.44 4.97e-14 Serum sulfate level; CESC cis rs7264396 0.790 rs6060539 chr20:34239382 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.77 0.43 1.78e-13 Total cholesterol levels; CESC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.02 0.8 8.6e-62 Prudent dietary pattern; CESC cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs524281 0.861 rs7941431 chr11:65960157 C/T cg14036092 chr11:66035641 RAB1B -0.59 -6.18 -0.35 2.45e-9 Electroencephalogram traits; CESC cis rs8141529 0.719 rs6005916 chr22:29233342 T/C cg15103426 chr22:29168792 CCDC117 0.7 9.85 0.52 1.06e-19 Lymphocyte counts; CESC cis rs710216 0.536 rs710221 chr1:43414200 G/A cg03128534 chr1:43423976 SLC2A1 0.75 11.41 0.57 8.38e-25 Red cell distribution width; CESC cis rs6951245 0.542 rs28460147 chr7:1217192 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.46 5.3 0.31 2.48e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.765 rs132920 chr22:41810170 T/C cg06481639 chr22:41940642 POLR3H 0.62 6.52 0.37 3.49e-10 Vitiligo; CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg17372223 chr3:52568218 NT5DC2 0.41 6.07 0.35 4.45e-9 Bipolar disorder; CESC cis rs2735413 0.750 rs60659587 chr16:78071554 G/T cg04733911 chr16:78082701 NA 0.4 5.09 0.3 6.69e-7 Systolic blood pressure (alcohol consumption interaction); CESC cis rs4642101 0.618 rs7612317 chr3:12820558 C/T cg24848339 chr3:12840334 CAND2 0.38 6.02 0.35 5.8e-9 QRS complex (12-leadsum); CESC cis rs2797160 1.000 rs1739354 chr6:126017808 G/C cg05901451 chr6:126070800 HEY2 0.45 6.46 0.37 5e-10 Endometrial cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11559952 chr10:112064744 SMNDC1 0.54 6.38 0.36 8.02e-10 Gut microbiome composition (summer); CESC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg03452623 chr4:187889614 NA -0.94 -18.76 -0.76 1.57e-50 Lobe attachment (rater-scored or self-reported); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg00214165 chr5:7869652 MTRR;FASTKD3 -0.48 -6.03 -0.35 5.51e-9 Recombination measurement; CESC cis rs9457247 0.663 rs2237277 chr6:167442107 G/A cg23791538 chr6:167370224 RNASET2 -0.57 -7.7 -0.43 2.7e-13 Crohn's disease; CESC cis rs7267979 1.000 rs4815412 chr20:25350325 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 18.14 0.74 2.23e-48 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04585227 chr7:158671570 WDR60 -0.58 -6.27 -0.36 1.49e-9 Gut microbiome composition (summer); CESC cis rs919433 0.963 rs4850428 chr2:198169772 G/A cg03934865 chr2:198174659 NA -0.41 -5.65 -0.33 4.09e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs6456156 0.766 rs150112 chr6:167509878 C/T cg07741184 chr6:167504864 NA -0.35 -6.26 -0.36 1.55e-9 Primary biliary cholangitis; CESC cis rs11690935 0.569 rs62183770 chr2:172838117 C/G cg13550731 chr2:172543902 DYNC1I2 0.5 6.86 0.39 4.72e-11 Schizophrenia; CESC cis rs9660992 0.573 rs7368327 chr1:205214792 C/T cg21643547 chr1:205240462 TMCC2 -0.37 -5.12 -0.3 5.9e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs28829049 0.508 rs4578242 chr1:19391565 G/C cg22333259 chr1:19394757 NA 0.33 5.25 0.31 3.12e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs4076764 0.914 rs6704467 chr1:163364512 A/G cg06092702 chr1:163392909 NA -0.41 -6.1 -0.35 3.84e-9 Motion sickness; CESC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg24060327 chr5:131705240 SLC22A5 0.76 10.91 0.56 3.9699999999999997e-23 Breast cancer; CESC cis rs7208859 0.573 rs73277960 chr17:29177441 T/C cg19761014 chr17:28927070 LRRC37B2 0.62 5.24 0.31 3.29e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9911578 1.000 rs1971659 chr17:57004787 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.13 0.3 5.67e-7 Intelligence (multi-trait analysis); CESC cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg04166393 chr7:2884313 GNA12 0.39 5.15 0.3 5.07e-7 Height; CESC cis rs10411936 0.682 rs6512113 chr19:16598269 C/T cg10248733 chr19:16607483 C19orf44;CALR3 0.58 6.9 0.39 3.75e-11 White blood cell count;Multiple sclerosis; CESC cis rs9649465 1.000 rs3958047 chr7:123327936 G/C cg04330084 chr7:123175371 IQUB -0.38 -5.22 -0.31 3.69e-7 Migraine; CESC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg17747265 chr1:1875780 NA -0.38 -6.05 -0.35 4.93e-9 Body mass index; CESC trans rs35110281 0.807 rs9976441 chr21:45046591 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 6.71 0.38 1.2e-10 Mean corpuscular volume; CESC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg22105103 chr4:187893119 NA -0.5 -7.28 -0.41 3.75e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg11764359 chr7:65958608 NA -0.79 -12.0 -0.59 9.01e-27 Aortic root size; CESC cis rs1185460 1.000 rs1784305 chr11:118942048 G/A cg01677386 chr11:118938358 VPS11 -0.45 -5.71 -0.33 3e-8 Coronary artery disease; CESC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg04315214 chr1:2043799 PRKCZ 0.65 11.4 0.57 9.18e-25 Height; CESC cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg11764359 chr7:65958608 NA -0.82 -9.58 -0.51 7.32e-19 Aortic root size; CESC cis rs2880765 0.835 rs7180923 chr15:86050890 A/T cg19183879 chr15:85880815 NA -0.25 -5.23 -0.31 3.48e-7 Coronary artery disease; CESC cis rs4654899 0.758 rs9426652 chr1:21458151 G/A cg05370193 chr1:21551575 ECE1 0.37 5.51 0.32 8.41e-8 Superior frontal gyrus grey matter volume; CESC trans rs10506458 0.915 rs17738485 chr12:63394932 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.34 -18.45 -0.75 1.83e-49 Hemostatic factors and hematological phenotypes; CESC cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.88 7.42 0.41 1.6e-12 Initial pursuit acceleration; CESC cis rs6546550 0.935 rs4241261 chr2:70063660 A/G cg02498382 chr2:70120550 SNRNP27 -0.38 -6.62 -0.38 1.97e-10 Prevalent atrial fibrillation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00735591 chr19:10828665 DNM2;MIR638 -0.63 -7.01 -0.4 1.97e-11 Gut microbiome composition (summer); CESC cis rs425277 1.000 rs262672 chr1:2080813 G/T cg24578937 chr1:2090814 PRKCZ 0.55 9.54 0.51 9.57e-19 Height; CESC cis rs561341 1.000 rs510264 chr17:30323414 A/G cg00745463 chr17:30367425 LRRC37B -0.86 -7.76 -0.43 1.8e-13 Hip circumference adjusted for BMI; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg25131247 chr11:118660965 DDX6 0.45 6.09 0.35 4.03e-9 Recombination measurement; CESC cis rs12973672 1.000 rs10414846 chr19:35772471 A/G cg12095397 chr19:35769544 USF2 -0.54 -7.34 -0.41 2.6e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2439831 0.681 rs825739 chr15:43592428 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.92 10.9 0.56 4.16e-23 Lung cancer in ever smokers; CESC cis rs9470366 0.883 rs9462210 chr6:36628953 G/A cg08179530 chr6:36648295 CDKN1A 0.5 6.05 0.35 4.94e-9 QRS duration; CESC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg02569458 chr12:86230093 RASSF9 -0.46 -7.15 -0.4 8.28e-12 Major depressive disorder; CESC cis rs3105593 1.000 rs62017210 chr15:50960620 T/C cg08437265 chr15:50716283 USP8 0.45 5.92 0.34 1e-8 QT interval; CESC cis rs7267979 1.000 rs6050617 chr20:25421648 C/T cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.4e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.56 7.84 0.43 1.07e-13 Intelligence (multi-trait analysis); CESC cis rs17125944 0.686 rs2296495 chr14:53379878 G/A cg00686598 chr14:53173677 PSMC6 0.96 7.22 0.41 5.39e-12 Alzheimer's disease (late onset); CESC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg16545954 chr1:2118288 C1orf86 0.34 6.44 0.37 5.68e-10 Height; CESC cis rs12464559 0.649 rs9287998 chr2:152621356 C/T cg01189475 chr2:152685088 ARL5A 0.65 5.72 0.33 2.94e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs3820928 0.904 rs2396432 chr2:227765891 C/T cg11843606 chr2:227700838 RHBDD1 -0.45 -5.87 -0.34 1.27e-8 Pulmonary function; CESC cis rs7188697 0.922 rs246258 chr16:58579274 A/G cg21335942 chr16:58549945 SETD6 -0.47 -5.64 -0.33 4.31e-8 QT interval; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg27266822 chr1:16073415 TMEM82 -0.4 -5.99 -0.35 6.64e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7772486 0.790 rs2265918 chr6:146219164 A/G cg05347473 chr6:146136440 FBXO30 0.55 7.05 0.4 1.57e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg26338869 chr17:61819248 STRADA 0.69 9.21 0.49 1.06e-17 Prudent dietary pattern; CESC cis rs1267303 0.642 rs114746843 chr1:46999239 C/A cg25110126 chr1:46999211 NA 1.07 12.0 0.59 8.98e-27 Monobrow; CESC cis rs1448094 0.717 rs7298614 chr12:86296513 C/T cg02569458 chr12:86230093 RASSF9 0.36 5.07 0.3 7.55e-7 Major depressive disorder; CESC cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.6 -8.71 -0.47 3.35e-16 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04306007 chr2:161350288 RBMS1 -0.52 -6.0 -0.35 6.59e-9 Gut microbiome composition (summer); CESC cis rs3892630 0.878 rs6510277 chr19:33183669 C/A cg13157960 chr19:33183277 NUDT19 0.53 5.2 0.3 4.04e-7 Red blood cell traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02500917 chr7:100080970 C7orf51 0.62 6.72 0.38 1.12e-10 Gut microbiome composition (summer); CESC cis rs6089584 0.507 rs6061989 chr20:60627893 C/T cg24733560 chr20:60626293 TAF4 0.48 7.12 0.4 1e-11 Body mass index; CESC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg13206674 chr6:150067644 NUP43 0.43 6.09 0.35 4e-9 Lung cancer; CESC cis rs11122272 0.735 rs910823 chr1:231498766 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.61 -0.42 4.76e-13 Hemoglobin concentration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10165071 chr2:217557160 IGFBP5 0.43 6.33 0.36 1.02e-9 Fibrinogen levels; CESC cis rs6429082 0.523 rs704718 chr1:235666159 A/T cg26050004 chr1:235667680 B3GALNT2 0.82 12.98 0.62 3.8e-30 Adiposity; CESC cis rs9325144 0.534 rs4882283 chr12:38710249 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.5 0.32 8.96e-8 Morning vs. evening chronotype; CESC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg05872129 chr22:39784769 NA -0.82 -10.06 -0.53 2.22e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg08499158 chr17:42289980 UBTF -0.51 -6.3 -0.36 1.21e-9 Total body bone mineral density; CESC cis rs208520 0.802 rs208496 chr6:66930786 G/C cg07460842 chr6:66804631 NA -0.9 -10.86 -0.55 5.7e-23 Exhaled nitric oxide output; CESC cis rs6429082 0.667 rs10802800 chr1:235706283 A/G cg26050004 chr1:235667680 B3GALNT2 -0.47 -5.12 -0.3 5.77e-7 Adiposity; CESC cis rs2806561 0.704 rs588387 chr1:23523689 A/G cg12483005 chr1:23474871 LUZP1 0.43 6.55 0.37 3.06e-10 Height; CESC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.61 -7.86 -0.44 9.39e-14 Tonsillectomy; CESC cis rs8078723 0.668 rs3859192 chr17:38128648 C/T cg17467752 chr17:38218738 THRA 0.54 7.8 0.43 1.38e-13 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs6500395 0.962 rs9921741 chr16:48589896 G/A cg04672837 chr16:48644449 N4BP1 0.46 5.61 0.33 5.16e-8 Response to tocilizumab in rheumatoid arthritis; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg07189025 chr1:235671652 NA 0.41 6.29 0.36 1.27e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs709082 0.624 rs709093 chr3:191462300 T/C cg25305879 chr2:106814630 NA 0.41 6.4 0.37 7.05e-10 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.716 rs35195511 chr4:98859660 G/A cg05340658 chr4:99064831 C4orf37 0.75 11.17 0.57 5.26e-24 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.26e-11 Skin colour saturation; CESC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg18402987 chr7:1209562 NA 0.77 7.88 0.44 8.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8058578 1.000 rs67456513 chr16:30714828 A/T cg00531865 chr16:30841666 NA -0.44 -5.77 -0.33 2.15e-8 Multiple myeloma; CESC cis rs3820068 0.581 rs16851848 chr1:15927698 G/A cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs3617 0.625 rs11922961 chr3:52868610 T/C cg07507251 chr3:52567010 NT5DC2 -0.31 -5.34 -0.31 2.03e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs67311347 0.910 rs7617361 chr3:40373259 G/T cg01475735 chr3:40494733 NA -0.4 -5.2 -0.3 4.05e-7 Renal cell carcinoma; CESC trans rs2727020 0.729 rs34647977 chr11:49195543 G/A cg03929089 chr4:120376271 NA -0.78 -11.91 -0.59 1.72e-26 Coronary artery disease; CESC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg13114125 chr14:105738426 BRF1 -0.9 -11.3 -0.57 1.99e-24 Mean platelet volume;Platelet distribution width; CESC cis rs9916302 0.904 rs8076546 chr17:37555403 G/A cg20243544 chr17:37824526 PNMT -0.49 -6.22 -0.36 1.94e-9 Glomerular filtration rate (creatinine); CESC cis rs5758659 0.714 rs5751220 chr22:42516205 A/C cg04733989 chr22:42467013 NAGA -0.4 -5.41 -0.32 1.39e-7 Cognitive function; CESC cis rs2370759 1.000 rs11597888 chr10:32635834 G/A cg01819863 chr10:32635814 EPC1 1.16 12.73 0.62 2.71e-29 Sexual dysfunction (female); CESC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg00106254 chr7:1943704 MAD1L1 -0.48 -5.95 -0.34 8.35e-9 Bipolar disorder and schizophrenia; CESC cis rs9916302 0.904 rs4511574 chr17:37532916 A/G cg20243544 chr17:37824526 PNMT 0.45 5.53 0.32 7.59e-8 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04081153 chr1:27021879 ARID1A 0.59 6.44 0.37 5.44e-10 Gut microbiome composition (summer); CESC trans rs11764590 0.756 rs17132130 chr7:2108036 G/C cg11693508 chr17:37793320 STARD3 0.54 6.1 0.35 3.77e-9 Neuroticism; CESC cis rs11252926 0.502 rs7072510 chr10:455596 C/T cg18196295 chr10:418757 DIP2C 0.51 6.9 0.39 3.93e-11 Psychosis in Alzheimer's disease; CESC cis rs7772697 0.632 rs7742644 chr6:149426296 C/T cg02561343 chr6:149291652 UST 0.31 5.03 0.3 9.06e-7 Diabetic retinopathy; CESC cis rs651907 0.557 rs7612283 chr3:101434919 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.88 0.34 1.22e-8 Colorectal cancer; CESC cis rs3087591 0.960 rs9303642 chr17:29578360 A/G cg24425628 chr17:29625626 OMG;NF1 -0.42 -5.25 -0.31 3.18e-7 Hip circumference; CESC cis rs7631605 0.905 rs6773752 chr3:37225837 C/T cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.18 -0.3 4.37e-7 Cerebrospinal P-tau181p levels; CESC cis rs6736093 0.966 rs3811633 chr2:112754880 G/A cg12686935 chr2:112915763 FBLN7 -0.43 -5.66 -0.33 3.94e-8 Coronary artery disease; CESC cis rs11792861 0.926 rs7046725 chr9:111882729 T/G cg05043794 chr9:111880884 C9orf5 -0.38 -6.27 -0.36 1.49e-9 Menarche (age at onset); CESC cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.21e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg27170947 chr2:26402098 FAM59B 0.87 9.85 0.52 1.01e-19 Gut microbiome composition (summer); CESC cis rs290268 0.874 rs290990 chr9:93561695 A/G cg02608019 chr9:93564028 SYK -0.47 -6.93 -0.39 3.13e-11 Platelet count; CESC cis rs4901869 0.966 rs9972208 chr14:59336116 C/T cg02291164 chr14:59296302 NA 0.45 7.73 0.43 2.21e-13 Panic disorder; CESC cis rs854765 0.693 rs12941039 chr17:17765655 C/T cg09796270 chr17:17721594 SREBF1 -0.46 -6.47 -0.37 4.84e-10 Total body bone mineral density; CESC cis rs1062177 0.826 rs1549920 chr5:151140844 A/T cg12924095 chr5:151150029 G3BP1 0.42 5.67 0.33 3.79e-8 Preschool internalizing problems; CESC cis rs7726839 0.555 rs4541696 chr5:581053 A/G cg09021430 chr5:549028 NA -0.6 -12.23 -0.6 1.42e-27 Obesity-related traits; CESC cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg17366294 chr4:99064904 C4orf37 0.54 7.16 0.4 8.11e-12 Colonoscopy-negative controls vs population controls; CESC cis rs2014572 0.967 rs11667407 chr19:57763122 C/T cg12963866 chr19:57752005 ZNF805 -0.47 -6.35 -0.36 9.56e-10 Hyperactive-impulsive symptoms; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06659073 chr6:158589307 SERAC1;GTF2H5 0.56 6.09 0.35 3.98e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg03806693 chr22:41940476 POLR3H 1.11 13.31 0.63 2.67e-31 Vitiligo; CESC cis rs76878669 0.561 rs3177514 chr11:66130358 T/G cg18002602 chr11:66138449 SLC29A2 0.39 6.48 0.37 4.49e-10 Educational attainment (years of education); CESC cis rs7264396 0.790 rs10211771 chr20:34219994 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -12.04 -0.59 6.24e-27 Total cholesterol levels; CESC cis rs7131987 0.903 rs67517901 chr12:29421346 A/G cg09582351 chr12:29534625 ERGIC2 -0.35 -5.52 -0.32 8.08e-8 QT interval; CESC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg23161317 chr6:28129485 ZNF389 0.52 6.63 0.38 1.86e-10 Depression; CESC cis rs1801251 0.963 rs13011298 chr2:233612996 A/G cg25237894 chr2:233734115 C2orf82 0.45 7.91 0.44 6.96e-14 Coronary artery disease; CESC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg11965913 chr1:205819406 PM20D1 -0.76 -10.93 -0.56 3.42e-23 Menarche (age at onset); CESC cis rs9595066 0.712 rs4391951 chr13:44755071 C/T cg04068111 chr13:44716778 NA 0.41 5.46 0.32 1.1e-7 Schizophrenia; CESC trans rs10986105 1.000 rs7859011 chr9:126678431 C/T cg01909245 chr11:1873757 LSP1 0.53 6.28 0.36 1.38e-9 Polycystic ovary syndrome; CESC cis rs13064411 0.735 rs7631138 chr3:113231925 A/T cg18753928 chr3:113234510 CCDC52 -0.49 -5.94 -0.34 8.7e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg02187348 chr16:89574699 SPG7 0.61 8.55 0.47 9.83e-16 Multiple myeloma (IgH translocation); CESC trans rs7072793 0.591 rs3118470 chr10:6101713 A/G cg09000804 chr14:104682988 NA -0.38 -6.32 -0.36 1.12e-9 Plasma t-tau levels; CESC cis rs4642101 0.640 rs7629354 chr3:12827746 T/G cg24848339 chr3:12840334 CAND2 0.38 5.8 0.34 1.89e-8 QRS complex (12-leadsum); CESC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg10792982 chr14:105748885 BRF1 0.4 5.38 0.31 1.64e-7 Mean platelet volume;Platelet distribution width; CESC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.6 0.47 6.99e-16 Menopause (age at onset); CESC cis rs847577 0.722 rs1013886 chr7:97709861 A/G cg21770322 chr7:97807741 LMTK2 -0.65 -10.7 -0.55 1.85e-22 Breast cancer; CESC cis rs79149102 0.649 rs1531163 chr15:75113083 A/G cg17294928 chr15:75287854 SCAMP5 -0.69 -5.1 -0.3 6.55e-7 Lung cancer; CESC cis rs2243480 1.000 rs2460422 chr7:65601505 C/T cg18252515 chr7:66147081 NA -1.42 -14.5 -0.67 1.8e-35 Diabetic kidney disease; CESC cis rs637571 0.544 rs56239996 chr11:65730003 A/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 6.22 0.36 1.92e-9 Eosinophil percentage of white cells; CESC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg26314531 chr2:26401878 FAM59B -0.62 -6.85 -0.39 5.1e-11 Gut microbiome composition (summer); CESC cis rs1256061 0.603 rs1269056 chr14:64743890 T/C cg21174375 chr14:64681225 SYNE2 0.51 6.77 0.38 8.31e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg05340658 chr4:99064831 C4orf37 0.84 13.04 0.63 2.35e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2108622 1.000 rs62107762 chr19:15982538 C/G cg13772218 chr19:15982569 NA 0.37 6.95 0.39 2.87e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.86 10.24 0.53 5.93e-21 Smoking behavior; CESC cis rs7223966 1.000 rs8070650 chr17:61744040 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.16 -0.3 4.73e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg20243544 chr17:37824526 PNMT -0.47 -5.94 -0.34 9.04e-9 Glomerular filtration rate (creatinine); CESC cis rs72634258 0.519 rs35197830 chr1:7930983 A/G cg00042356 chr1:8021962 PARK7 0.51 5.66 0.33 3.91e-8 Inflammatory bowel disease; CESC cis rs10078 1.000 rs10078 chr5:438102 G/T cg15813090 chr5:442598 EXOC3;C5orf55 0.36 5.34 0.31 2e-7 Fat distribution (HIV); CESC cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg18016565 chr1:150552671 MCL1 -0.42 -6.86 -0.39 4.98e-11 Tonsillectomy; CESC cis rs9457247 1.000 rs448060 chr6:167382622 A/G cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.27e-8 Crohn's disease; CESC cis rs4843747 0.671 rs72818577 chr16:88111181 G/A cg06915872 chr16:87998081 BANP 0.44 5.2 0.3 3.95e-7 Menopause (age at onset); CESC cis rs2380220 0.720 rs9374178 chr6:95979974 G/T cg15832292 chr6:96025679 MANEA 0.62 6.87 0.39 4.62e-11 Behavioural disinhibition (generation interaction); CESC cis rs2288912 0.807 rs7251501 chr19:45455706 C/T cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.51e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg18446336 chr7:2847575 GNA12 -0.37 -6.24 -0.36 1.73e-9 Height; CESC cis rs1832871 0.711 rs9459826 chr6:158680396 C/G cg07165851 chr6:158734300 TULP4 -0.52 -5.63 -0.33 4.65e-8 Height; CESC cis rs9291683 0.530 rs11723591 chr4:9985398 T/A cg00071950 chr4:10020882 SLC2A9 0.76 13.25 0.63 4.21e-31 Bone mineral density; CESC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg17143192 chr8:8559678 CLDN23 0.77 8.74 0.47 2.64e-16 Obesity-related traits; CESC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg11644478 chr21:40555479 PSMG1 0.89 12.26 0.6 1.15e-27 Cognitive function; CESC cis rs7640424 0.620 rs7637244 chr3:107815763 T/A cg09227934 chr3:107805635 CD47 -0.45 -5.58 -0.32 5.86e-8 Body mass index; CESC cis rs116095464 0.558 rs55664502 chr5:270485 T/C cg22857025 chr5:266934 NA -1.29 -18.61 -0.75 5.33e-50 Breast cancer; CESC cis rs9733 0.688 rs12725667 chr1:150766070 A/T cg18016565 chr1:150552671 MCL1 -0.36 -5.89 -0.34 1.19e-8 Tonsillectomy; CESC trans rs875971 0.929 rs778682 chr7:65837934 A/G cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.66e-9 Aortic root size; CESC cis rs10751667 0.666 rs7123912 chr11:963936 T/C cg20946044 chr11:1010712 AP2A2 -0.38 -5.35 -0.31 1.92e-7 Alzheimer's disease (late onset); CESC cis rs1448094 0.621 rs10863091 chr12:86282240 T/C cg02569458 chr12:86230093 RASSF9 0.42 6.15 0.35 2.81e-9 Major depressive disorder; CESC cis rs27434 0.583 rs34756 chr5:96152383 C/T cg16492584 chr5:96139282 ERAP1 0.38 5.56 0.32 6.71e-8 Ankylosing spondylitis; CESC cis rs6991838 0.584 rs7823840 chr8:66519001 A/G cg13398993 chr8:66546079 ARMC1 -0.45 -5.41 -0.32 1.38e-7 Intelligence (multi-trait analysis); CESC cis rs4588572 0.688 rs11743511 chr5:77692819 C/T cg11547950 chr5:77652471 NA -0.41 -5.69 -0.33 3.27e-8 Triglycerides; CESC cis rs9583531 0.891 rs7999536 chr13:111382199 G/A cg24331049 chr13:111365604 ING1 0.76 8.03 0.44 3.24e-14 Coronary artery disease; CESC cis rs7894051 1.000 rs7074435 chr10:135190570 G/T cg20534287 chr10:135191450 PAOX 0.57 5.57 0.32 6.28e-8 Lifespan; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06426436 chr5:133339613 VDAC1 0.49 6.21 0.36 2.02e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10461617 0.541 rs7715822 chr5:56043600 G/T cg22800045 chr5:56110881 MAP3K1 0.7 6.42 0.37 6.29e-10 Type 2 diabetes; CESC cis rs3796619 1.000 rs4045481 chr4:1090625 C/T cg27284194 chr4:1044797 NA 0.38 5.69 0.33 3.4e-8 Recombination rate (males); CESC cis rs6964587 0.935 rs28412174 chr7:91577245 T/G cg17063962 chr7:91808500 NA -0.57 -7.61 -0.42 4.66e-13 Breast cancer; CESC cis rs9916302 0.784 rs4795382 chr17:37700860 A/G cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.89e-10 Glomerular filtration rate (creatinine); CESC cis rs17376456 0.877 rs9314100 chr5:93447394 T/C cg25358565 chr5:93447407 FAM172A 1.19 11.28 0.57 2.31e-24 Diabetic retinopathy; CESC cis rs2072732 0.821 rs7412983 chr1:2943183 A/C cg03976712 chr1:2946727 NA 0.34 5.35 0.31 1.9e-7 Plateletcrit; CESC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.98 0.39 2.35e-11 Bipolar disorder; CESC cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.41 6.84 0.39 5.54e-11 Personality dimensions; CESC cis rs12586317 0.508 rs10134914 chr14:35425012 T/G cg16230307 chr14:35515116 FAM177A1 0.83 10.08 0.53 1.91e-20 Psoriasis; CESC cis rs7177699 0.534 rs7403708 chr15:79123885 T/C cg04896959 chr15:78267971 NA 0.32 5.03 0.3 8.89e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs75229567 0.541 rs775443 chr12:70122623 C/T cg10114359 chr12:70132523 RAB3IP -0.75 -5.91 -0.34 1.04e-8 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs1728785 1.000 rs1069288 chr16:68585285 C/G cg02972257 chr16:68554789 NA -0.55 -6.28 -0.36 1.37e-9 Ulcerative colitis; CESC cis rs854765 0.647 rs4365346 chr17:17989373 G/T cg04398451 chr17:18023971 MYO15A -0.75 -11.07 -0.56 1.18e-23 Total body bone mineral density; CESC cis rs7843479 0.562 rs4872191 chr8:21824547 A/G cg17168535 chr8:21777572 XPO7 0.75 11.94 0.59 1.41e-26 Mean corpuscular volume; CESC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg05863683 chr7:1912471 MAD1L1 0.38 5.89 0.34 1.19e-8 Bipolar disorder and schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00289125 chr2:20251812 LAPTM4A 0.43 6.06 0.35 4.7e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg22105103 chr4:187893119 NA 0.46 6.84 0.39 5.33e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6831352 0.842 rs1230156 chr4:99989626 C/T cg12011299 chr4:100065546 ADH4 0.67 7.93 0.44 6.27e-14 Alcohol dependence; CESC cis rs796364 0.951 rs72932280 chr2:200996851 G/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -6.86 -0.39 4.78e-11 Schizophrenia; CESC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg02018176 chr4:1364513 KIAA1530 0.43 6.07 0.35 4.53e-9 Longevity; CESC cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg17366294 chr4:99064904 C4orf37 0.58 8.26 0.45 7.11e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 0.966 rs6449330 chr4:17703949 C/T cg16339924 chr4:17578868 LAP3 -0.58 -7.27 -0.41 4.04e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1707322 0.752 rs10789467 chr1:46118745 C/G cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10028773 0.515 rs9994488 chr4:120587781 C/T cg09307838 chr4:120376055 NA 0.69 9.05 0.49 3.22e-17 Educational attainment; CESC cis rs8067545 0.611 rs2189709 chr17:20083226 T/A cg13482628 chr17:19912719 NA -0.43 -5.74 -0.33 2.65e-8 Schizophrenia; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg08946332 chr17:6899888 ALOX12 -0.41 -5.98 -0.35 7.04e-9 Tonsillectomy; CESC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg18099408 chr3:52552593 STAB1 -0.4 -7.43 -0.42 1.52e-12 Electroencephalogram traits; CESC cis rs28829049 0.597 rs12563386 chr1:19455205 T/C cg13387374 chr1:19411106 UBR4 0.43 5.39 0.31 1.54e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs7814319 0.933 rs7002575 chr8:97242124 G/A cg20787634 chr8:97240163 UQCRB -0.63 -8.2 -0.45 1.03e-14 Lung function (FVC); CESC cis rs858239 0.537 rs6942981 chr7:23231548 C/T cg23682824 chr7:23144976 KLHL7 0.45 5.79 0.34 1.98e-8 Cerebrospinal fluid biomarker levels; CESC trans rs637571 0.607 rs574586 chr11:65697083 G/A cg17712092 chr4:129076599 LARP1B 0.78 10.5 0.54 8.89e-22 Eosinophil percentage of white cells; CESC cis rs12618769 0.597 rs72819996 chr2:99059983 G/A cg10123293 chr2:99228465 UNC50 0.39 5.18 0.3 4.49e-7 Bipolar disorder; CESC cis rs7188697 0.922 rs37036 chr16:58553348 T/C cg21335942 chr16:58549945 SETD6 0.46 5.41 0.32 1.44e-7 QT interval; CESC cis rs7727544 0.684 rs272893 chr5:131663062 T/C cg07395648 chr5:131743802 NA -0.44 -5.81 -0.34 1.79e-8 Blood metabolite levels; CESC cis rs7937682 0.575 rs7930208 chr11:111741463 T/C cg09085632 chr11:111637200 PPP2R1B 0.9 11.72 0.58 8.02e-26 Primary sclerosing cholangitis; CESC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg11859384 chr17:80120422 CCDC57 0.4 5.5 0.32 8.88e-8 Life satisfaction; CESC cis rs2180341 0.883 rs7760748 chr6:127690062 C/T cg27446573 chr6:127587934 RNF146 1.05 15.58 0.69 2.65e-39 Breast cancer; CESC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg24399712 chr22:39784796 NA 0.82 10.93 0.56 3.32e-23 Intelligence (multi-trait analysis); CESC cis rs17401966 0.838 rs1013953 chr1:10319459 T/A cg15208524 chr1:10270712 KIF1B 0.39 5.14 0.3 5.37e-7 Hepatocellular carcinoma; CESC trans rs2657294 0.620 rs4746261 chr10:76845632 C/T ch.2.195648145F chr2:195939902 NA 0.5 6.32 0.36 1.07e-9 Pneumonia; CESC cis rs7551222 0.634 rs11801289 chr1:204528969 G/C cg20240347 chr1:204465584 NA -0.28 -5.65 -0.33 4.12e-8 Schizophrenia; CESC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.21 -0.41 5.76e-12 Developmental language disorder (linguistic errors); CESC cis rs2710642 0.721 rs6727888 chr2:62887884 T/C cg17519650 chr2:63277830 OTX1 0.5 6.08 0.35 4.28e-9 LDL cholesterol levels;LDL cholesterol; CESC cis rs9300255 0.602 rs1790131 chr12:123701010 G/T cg19016782 chr12:123741754 C12orf65 -0.45 -6.5 -0.37 3.89e-10 Neutrophil percentage of white cells; CESC cis rs12451471 0.637 rs12950757 chr17:78096800 T/G cg24585782 chr17:78113791 EIF4A3 -0.6 -8.06 -0.44 2.7e-14 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs57506017 0.585 rs4721057 chr7:12267221 A/G cg23422036 chr7:12250390 TMEM106B 0.38 5.17 0.3 4.7e-7 Neuroticism; CESC cis rs6456156 0.524 rs6934043 chr6:167466449 C/T cg07741184 chr6:167504864 NA 0.35 6.08 0.35 4.1e-9 Primary biliary cholangitis; CESC cis rs7561273 0.609 rs1056122 chr2:24342505 C/T cg20701182 chr2:24300061 SF3B14 -0.46 -5.99 -0.35 6.81e-9 Quantitative traits; CESC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs2251381 0.750 rs2251186 chr21:30528880 G/A cg24692254 chr21:30365293 RNF160 0.78 10.55 0.54 5.89e-22 Selective IgA deficiency; CESC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 10.43 0.54 1.4e-21 Platelet count; CESC cis rs9486719 1.000 rs11153067 chr6:97039421 A/T cg18709589 chr6:96969512 KIAA0776 0.51 5.58 0.32 5.99e-8 Migraine;Coronary artery disease; CESC cis rs909002 0.800 rs7529064 chr1:32105192 C/A cg13919466 chr1:32135498 COL16A1 -0.46 -8.21 -0.45 1e-14 Intelligence (multi-trait analysis); CESC cis rs3749237 0.595 rs6797765 chr3:49423976 A/G cg02487422 chr3:49467188 NICN1 0.53 7.7 0.43 2.74e-13 Resting heart rate; CESC cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg05234568 chr11:5960015 NA -0.63 -7.53 -0.42 8.12e-13 DNA methylation (variation); CESC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg25036284 chr2:26402008 FAM59B -0.86 -9.4 -0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs2985817 chr1:67398607 G/C cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs55788414 0.932 rs9921748 chr16:81181783 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -7.04 -0.4 1.62e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs847577 0.588 rs6946915 chr7:97711340 C/G cg21770322 chr7:97807741 LMTK2 0.82 14.54 0.67 1.25e-35 Breast cancer; CESC cis rs1538970 1.000 rs4660853 chr1:45849090 C/T cg03146154 chr1:46216737 IPP 0.44 5.31 0.31 2.29e-7 Platelet count; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00746083 chr14:21905454 CHD8 -0.47 -6.04 -0.35 5.14e-9 Asthma; CESC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg07507251 chr3:52567010 NT5DC2 -0.33 -5.46 -0.32 1.07e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC trans rs7824557 0.545 rs2572380 chr8:11237477 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.13 -0.35 3.17e-9 Retinal vascular caliber; CESC cis rs523522 0.962 rs655530 chr12:121022275 T/C cg12219531 chr12:120966889 COQ5 0.76 10.07 0.53 2.15e-20 High light scatter reticulocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09133386 chr6:20404188 E2F3 -0.51 -7.6 -0.42 5.08e-13 Gambling; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09698166 chr20:21106763 PLK1S1 0.48 6.79 0.38 7.32e-11 Systemic lupus erythematosus; CESC cis rs2439831 0.850 rs28509275 chr15:44098105 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.71 7.07 0.4 1.37e-11 Lung cancer in ever smokers; CESC cis rs17253792 0.822 rs8006705 chr14:56171283 C/T cg01858014 chr14:56050164 KTN1 -0.75 -6.5 -0.37 3.96e-10 Putamen volume; CESC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg18099408 chr3:52552593 STAB1 -0.31 -5.18 -0.3 4.49e-7 Bipolar disorder; CESC cis rs7264396 0.677 rs6060553 chr20:34267386 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.84 0.39 5.52e-11 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20440414 chr17:46178346 CBX1 0.66 7.43 0.42 1.46e-12 Gut microbiome composition (summer); CESC cis rs7264396 0.635 rs6060656 chr20:34466382 G/A cg17201900 chr20:34330562 RBM39 0.5 5.07 0.3 7.37e-7 Total cholesterol levels; CESC cis rs897984 0.683 rs13337900 chr16:30822409 G/A cg00531865 chr16:30841666 NA -0.55 -8.34 -0.46 4.24e-15 Dementia with Lewy bodies; CESC cis rs2243480 0.803 rs423187 chr7:65509499 G/C cg25894440 chr7:65020034 NA -0.64 -5.28 -0.31 2.67e-7 Diabetic kidney disease; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg07274998 chr10:126107781 OAT -0.44 -6.15 -0.35 2.87e-9 Recombination measurement; CESC cis rs17376456 1.000 rs56046246 chr5:93531545 T/G cg25358565 chr5:93447407 FAM172A 1.18 11.23 0.57 3.38e-24 Diabetic retinopathy; CESC cis rs12900413 0.687 rs28653538 chr15:90304964 T/C cg24249390 chr15:90295951 MESP1 -0.4 -5.59 -0.32 5.74e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs1050631 1.000 rs719147 chr18:33698192 T/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.43 5.57 0.32 6.17e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs7084402 0.967 rs1896243 chr10:60276291 C/T cg07615347 chr10:60278583 BICC1 -0.58 -9.21 -0.49 1.01e-17 Refractive error; CESC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg12463550 chr7:65579703 CRCP -0.5 -6.43 -0.37 5.9e-10 Aortic root size; CESC cis rs10911232 0.507 rs10911206 chr1:183012423 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 13.67 0.64 1.52e-32 Hypertriglyceridemia; CESC cis rs561341 0.700 rs79272796 chr17:30226974 T/C cg13647721 chr17:30228624 UTP6 0.82 10.61 0.55 3.73e-22 Hip circumference adjusted for BMI; CESC cis rs1451375 0.527 rs6950777 chr7:50597056 G/A cg14593290 chr7:50529359 DDC 0.51 6.45 0.37 5.26e-10 Malaria; CESC cis rs2243480 1.000 rs6460274 chr7:65628484 T/A cg13147721 chr7:65941812 NA 0.97 9.19 0.49 1.2e-17 Diabetic kidney disease; CESC cis rs9640161 0.750 rs3800780 chr7:150027284 C/A cg10018233 chr7:150070692 REPIN1 0.43 6.35 0.36 9.1e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs11711311 0.955 rs2124105 chr3:113406003 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.67 8.6 0.47 7.08e-16 IgG glycosylation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19502932 chr11:6640663 TPP1 -0.45 -6.12 -0.35 3.33e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs16895831 0.519 rs12196290 chr6:42552548 G/A cg10605015 chr6:42532144 UBR2 -0.52 -5.81 -0.34 1.75e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs1538970 0.962 rs2185549 chr1:45814103 C/T cg03146154 chr1:46216737 IPP -0.46 -5.47 -0.32 1.04e-7 Platelet count; CESC cis rs6964587 0.967 rs1978061 chr7:91779242 G/A cg17063962 chr7:91808500 NA 0.59 8.22 0.45 8.94e-15 Breast cancer; CESC cis rs7089973 0.604 rs7915943 chr10:116618077 G/A cg23260525 chr10:116636907 FAM160B1 0.41 7.43 0.42 1.53e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11098499 0.954 rs13113483 chr4:120309039 C/T cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs7481584 0.624 rs2106229 chr11:3041195 G/A cg25174290 chr11:3078921 CARS -0.43 -5.86 -0.34 1.38e-8 Calcium levels; CESC cis rs3820928 0.874 rs13423046 chr2:227901805 G/T cg05526886 chr2:227700861 RHBDD1 -0.45 -5.7 -0.33 3.18e-8 Pulmonary function; CESC cis rs72781680 0.611 rs72783619 chr2:24311607 G/A cg20701182 chr2:24300061 SF3B14 0.93 10.58 0.54 4.83e-22 Lymphocyte counts; CESC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg11764359 chr7:65958608 NA 0.71 9.47 0.5 1.62e-18 Aortic root size; CESC cis rs1879734 0.731 rs10888804 chr1:54160570 C/T cg23596471 chr1:54105337 GLIS1 0.35 5.66 0.33 3.96e-8 Mitral valve prolapse; CESC cis rs11148252 0.595 rs4884522 chr13:53053768 C/A cg00495681 chr13:53174319 NA 0.61 8.32 0.46 4.58e-15 Lewy body disease; CESC cis rs11920090 0.800 rs11917504 chr3:170736708 A/T cg09710316 chr3:170744871 SLC2A2 0.41 5.08 0.3 7.3e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg19318889 chr4:1322082 MAEA 0.43 5.74 0.33 2.57e-8 Longevity; CESC cis rs56104184 0.775 rs73061695 chr19:49399988 T/C cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs17376456 0.877 rs7701974 chr5:93311417 C/T cg21475434 chr5:93447410 FAM172A 0.76 6.88 0.39 4.31e-11 Diabetic retinopathy; CESC cis rs2795502 1.000 rs2142991 chr10:43341105 C/T cg20628663 chr10:43360327 NA -0.61 -7.24 -0.41 4.87e-12 Blood protein levels; CESC cis rs2651899 0.872 rs207199 chr1:3076857 T/G cg07622451 chr1:3079886 PRDM16 0.31 5.6 0.33 5.47e-8 Migraine; CESC cis rs8141529 0.664 rs5762862 chr22:29252732 C/T cg15103426 chr22:29168792 CCDC117 0.54 6.65 0.38 1.62e-10 Lymphocyte counts; CESC cis rs7771547 0.573 rs664370 chr6:36393816 A/G cg07856975 chr6:36356162 ETV7 0.37 5.55 0.32 6.87e-8 Platelet distribution width; CESC cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg08847533 chr14:75593920 NEK9 0.6 7.78 0.43 1.62e-13 Caffeine consumption; CESC cis rs8070128 0.600 rs8071238 chr17:17900990 T/C cg04398451 chr17:18023971 MYO15A -0.68 -9.48 -0.5 1.54e-18 Total body bone mineral density; CESC cis rs9419702 0.568 rs7920966 chr10:133555185 G/T cg04492858 chr10:133558786 NA 0.43 6.37 0.36 8.39e-10 Survival in rectal cancer; CESC cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg06022373 chr22:39101656 GTPBP1 0.9 14.15 0.66 2.99e-34 Menopause (age at onset); CESC cis rs7666738 0.546 rs1863602 chr4:98909304 T/C cg05340658 chr4:99064831 C4orf37 0.6 7.48 0.42 1.06e-12 Colonoscopy-negative controls vs population controls; CESC cis rs6484504 0.600 rs208063 chr11:31159777 C/T cg14844989 chr11:31128820 NA -0.41 -5.85 -0.34 1.47e-8 Red blood cell count; CESC cis rs9487051 0.676 rs6568568 chr6:109597048 C/T cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 8.19e-8 Reticulocyte fraction of red cells; CESC cis rs9486719 0.843 rs2499787 chr6:96841762 G/C cg18709589 chr6:96969512 KIAA0776 0.57 5.66 0.33 3.94e-8 Migraine;Coronary artery disease; CESC cis rs7208859 0.623 rs35916850 chr17:29011173 G/A cg19761014 chr17:28927070 LRRC37B2 0.81 6.67 0.38 1.49e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6570726 0.935 rs585292 chr6:145862228 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.45 0.37 5.27e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs478304 0.651 rs78412025 chr11:65495696 T/C cg10518572 chr11:65560635 OVOL1 -0.33 -6.61 -0.38 2.09e-10 Acne (severe); CESC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg05564831 chr3:52568323 NT5DC2 0.43 6.21 0.36 2.06e-9 Bipolar disorder; CESC cis rs7851660 0.874 rs13299924 chr9:100627562 C/T cg13688889 chr9:100608707 NA -0.63 -8.87 -0.48 1.09e-16 Strep throat; CESC trans rs1814175 0.817 rs10839358 chr11:49770972 G/A cg03929089 chr4:120376271 NA -0.9 -14.97 -0.68 4.06e-37 Height; CESC cis rs62005083 0.748 rs72725911 chr14:74500621 G/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.7 5.22 0.31 3.68e-7 Mean corpuscular volume; CESC cis rs11122272 0.735 rs2808597 chr1:231532351 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs6701037 1.000 rs6683533 chr1:175125440 G/A cg00321850 chr1:175162397 KIAA0040 -0.42 -5.88 -0.34 1.22e-8 Alcohol dependence; CESC cis rs258892 0.793 rs6452682 chr5:72082390 T/G cg21869765 chr5:72125136 TNPO1 -0.42 -5.42 -0.32 1.36e-7 Small cell lung carcinoma; CESC cis rs16910800 0.638 rs12273883 chr11:23164569 C/G cg20040320 chr11:23191996 NA 0.64 6.34 0.36 1e-9 Cancer; CESC cis rs9815354 1.000 rs9848754 chr3:41753647 C/T cg03022575 chr3:42003672 ULK4 0.51 5.06 0.3 7.69e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs79387448 0.935 rs7567133 chr2:103253128 C/A cg09003973 chr2:102972529 NA 0.57 5.15 0.3 5.01e-7 Gut microbiota (bacterial taxa); CESC cis rs11969893 0.850 rs9404055 chr6:101302260 C/T cg12253828 chr6:101329408 ASCC3 1.11 9.79 0.52 1.5700000000000001e-19 Economic and political preferences (immigration/crime); CESC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15422734 chr19:49206777 FUT2 -0.56 -6.44 -0.37 5.54e-10 Gut microbiome composition (summer); CESC cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg24308560 chr3:49941425 MST1R 0.6 8.46 0.46 1.85e-15 Body mass index; CESC cis rs965469 1.000 rs2236108 chr20:3286331 A/C cg25506879 chr20:3388711 C20orf194 -0.54 -5.88 -0.34 1.24e-8 IFN-related cytopenia; CESC cis rs17826219 0.706 rs2322197 chr17:29105805 T/C cg13385521 chr17:29058706 SUZ12P 0.74 6.04 0.35 5.1e-9 Body mass index; CESC cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg01475377 chr6:109611718 NA -0.52 -8.83 -0.48 1.41e-16 Reticulocyte fraction of red cells; CESC cis rs7267979 0.966 rs2482918 chr20:25412135 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -16.55 -0.71 9.69e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs6500395 0.963 rs12444902 chr16:48667126 G/T cg04672837 chr16:48644449 N4BP1 0.49 6.26 0.36 1.54e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7584330 0.737 rs12469894 chr2:238365528 T/C cg14458575 chr2:238380390 NA 0.62 8.39 0.46 3.03e-15 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05617452 chr16:1877333 HAGH;FAHD1 0.59 6.93 0.39 3.24e-11 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07272677 chr4:186741447 SORBS2 0.45 6.35 0.36 9.55e-10 Fibrinogen levels; CESC cis rs72781680 1.000 rs17712391 chr2:24245659 C/T cg20701182 chr2:24300061 SF3B14 0.83 7.16 0.4 8.12e-12 Lymphocyte counts; CESC cis rs9788721 0.630 rs77681598 chr15:78906103 C/A cg24631222 chr15:78858424 CHRNA5 0.42 5.44 0.32 1.24e-7 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23409613 chr14:53196849 STYX 0.64 7.99 0.44 4.08e-14 Gut microbiome composition (summer); CESC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg09177884 chr7:1199841 ZFAND2A -0.57 -7.38 -0.41 1.99e-12 Longevity;Endometriosis; CESC cis rs11997175 0.646 rs6993892 chr8:33729200 T/C ch.8.33884649F chr8:33765107 NA 0.56 7.32 0.41 3.02e-12 Body mass index; CESC cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.48 -5.43 -0.32 1.26e-7 Osteoporosis; CESC cis rs6570726 0.533 rs1832374 chr6:145717752 A/G cg23711669 chr6:146136114 FBXO30 0.48 5.72 0.33 2.91e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1499614 0.522 rs13247442 chr7:66188858 T/C cg18252515 chr7:66147081 NA -1.28 -9.23 -0.49 9.02e-18 Gout; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10735211 chr4:4310922 ZNF509 0.44 6.3 0.36 1.24e-9 Fibrinogen levels; CESC cis rs62458065 0.513 rs10265319 chr7:32571564 A/C cg20159608 chr7:32802032 NA -0.55 -6.16 -0.35 2.74e-9 Metabolite levels (HVA/MHPG ratio); CESC cis rs748404 0.697 rs501884 chr15:43553982 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.98 0.44 4.38e-14 Lung cancer; CESC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg26314531 chr2:26401878 FAM59B -0.62 -6.91 -0.39 3.66e-11 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg08413153 chr17:46185283 SNX11 -0.51 -6.69 -0.38 1.3100000000000001e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2073300 0.609 rs6137948 chr20:23416845 G/A cg16736954 chr20:23401023 NAPB 0.78 5.79 0.34 2e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 10.57 0.54 5.17e-22 Personality dimensions; CESC cis rs17209837 0.607 rs117917293 chr7:87114824 G/C cg00919237 chr7:87102261 ABCB4 -0.46 -5.88 -0.34 1.21e-8 Gallbladder cancer; CESC cis rs7208859 0.623 rs73269974 chr17:29112384 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3824867 0.920 rs9919526 chr11:47451623 C/T cg20307385 chr11:47447363 PSMC3 -0.47 -5.48 -0.32 9.68e-8 Mean corpuscular hemoglobin; CESC cis rs5997397 0.934 rs6005864 chr22:29157487 A/G cg02153584 chr22:29168773 CCDC117 -0.56 -7.45 -0.42 1.29e-12 Red cell distribution width; CESC cis rs7762018 0.891 rs7764839 chr6:170146351 C/A cg05834625 chr6:170176447 C6orf70 0.65 7.17 0.4 7.57e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1348850 0.874 rs12996447 chr2:178283592 C/T cg22681709 chr2:178499509 PDE11A -0.4 -5.95 -0.34 8.31e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg24250549 chr1:154909240 PMVK 0.72 10.85 0.55 6.34e-23 Prostate cancer; CESC cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg13877915 chr19:58951672 ZNF132 0.39 5.62 0.33 4.74e-8 Uric acid clearance; CESC trans rs11098499 0.954 rs1022145 chr4:120230979 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.65 0.51 4.55e-19 Corneal astigmatism; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg13736585 chr7:43909721 MRPS24 0.47 6.19 0.36 2.23e-9 Thyroid stimulating hormone; CESC cis rs1707322 0.752 rs6703748 chr1:46095976 G/A cg05343316 chr1:45956843 TESK2 0.51 6.35 0.36 9.45e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1814175 0.654 rs7482446 chr11:49779020 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -19.33 -0.76 1.48e-52 Height; CESC cis rs3733585 0.699 rs4339211 chr4:9947658 C/T cg11266682 chr4:10021025 SLC2A9 -0.59 -11.16 -0.57 5.99e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10871290 0.881 rs11649338 chr16:74471420 C/T cg01733217 chr16:74700730 RFWD3 -0.61 -8.19 -0.45 1.09e-14 Breast cancer; CESC cis rs9814567 1.000 rs55913793 chr3:134285968 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.05 -0.35 4.79e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2637266 1.000 rs7081214 chr10:78361134 G/A cg18941641 chr10:78392320 NA 0.41 7.73 0.43 2.17e-13 Pulmonary function; CESC cis rs12586317 0.620 rs12588810 chr14:35554484 C/T cg05294307 chr14:35346193 BAZ1A -0.48 -5.17 -0.3 4.71e-7 Psoriasis; CESC cis rs72945132 1.000 rs72945129 chr11:70110808 C/T cg00319359 chr11:70116639 PPFIA1 0.84 7.84 0.43 1.11e-13 Coronary artery disease; CESC cis rs2427308 0.643 rs477859 chr20:60937597 A/G cg24112000 chr20:60950667 NA 0.45 5.39 0.31 1.57e-7 Colorectal cancer; CESC cis rs854765 0.547 rs7212167 chr17:17913504 G/A cg16928487 chr17:17741425 SREBF1 -0.57 -9.89 -0.52 7.74e-20 Total body bone mineral density; CESC cis rs1215050 0.740 rs1214997 chr4:99041533 A/T cg05340658 chr4:99064831 C4orf37 0.57 7.55 0.42 7.11e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4555082 0.874 rs78923231 chr14:105754033 C/T cg13114125 chr14:105738426 BRF1 -0.91 -10.96 -0.56 2.65e-23 Mean platelet volume;Platelet distribution width; CESC cis rs847577 0.550 rs12670686 chr7:97708397 A/G cg24562669 chr7:97807699 LMTK2 0.78 13.16 0.63 8.64e-31 Breast cancer; CESC cis rs4450798 0.744 rs4611801 chr3:13763808 A/G cg05589046 chr3:13742034 LOC285375 0.35 5.28 0.31 2.71e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg11890956 chr21:40555474 PSMG1 1.11 17.72 0.74 6.83e-47 Cognitive function; CESC cis rs7267979 0.866 rs437635 chr20:25456888 A/G cg08601574 chr20:25228251 PYGB 0.37 5.36 0.31 1.77e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs1707322 1.000 rs11211243 chr1:46455433 G/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7918232 0.941 rs1753413 chr10:27397112 T/C cg14240646 chr10:27532245 ACBD5 -0.68 -6.37 -0.36 8.36e-10 Breast cancer; CESC cis rs96067 0.772 rs6700737 chr1:36598214 A/G cg24686825 chr1:36642396 MAP7D1 -0.53 -5.88 -0.34 1.23e-8 Corneal structure; CESC cis rs2228479 0.541 rs62052173 chr16:89950739 T/C cg06558623 chr16:89946397 TCF25 0.59 5.83 0.34 1.59e-8 Skin colour saturation; CESC cis rs4523957 0.583 rs6503302 chr17:2052704 C/T cg16513277 chr17:2031491 SMG6 -0.79 -11.67 -0.58 1.14e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs8017423 0.845 rs80167706 chr14:90727629 G/C cg14092571 chr14:90743983 NA -0.55 -8.17 -0.45 1.24e-14 Mortality in heart failure; CESC cis rs13385 0.769 rs36050010 chr5:139569859 C/A cg26211634 chr5:139558579 C5orf32 0.47 5.28 0.31 2.75e-7 Atrial fibrillation; CESC cis rs712039 0.617 rs36081240 chr17:35785054 G/A cg16670864 chr17:35848621 DUSP14 0.43 5.32 0.31 2.24e-7 Tuberculosis; CESC cis rs227584 0.663 rs2040810 chr17:42243771 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.4 -5.98 -0.34 7.24e-9 Bone mineral density (hip);Bone mineral density; CESC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg11764359 chr7:65958608 NA 0.69 9.06 0.49 2.98e-17 Aortic root size; CESC cis rs3767633 0.925 rs1553444 chr1:161813515 C/T cg09175582 chr1:161736000 ATF6 0.85 7.18 0.4 6.84e-12 IgG glycosylation; CESC cis rs854765 0.583 rs4925125 chr17:17794444 T/C cg16928487 chr17:17741425 SREBF1 0.53 9.01 0.48 4.08e-17 Total body bone mineral density; CESC cis rs9649465 0.967 rs12534834 chr7:123307079 T/C cg04330084 chr7:123175371 IQUB -0.37 -5.05 -0.3 8.09e-7 Migraine; CESC trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg03929089 chr4:120376271 NA 0.78 11.75 0.59 5.9e-26 Height; CESC cis rs7666738 0.830 rs28761309 chr4:98867393 C/T cg17366294 chr4:99064904 C4orf37 0.54 7.48 0.42 1.1e-12 Colonoscopy-negative controls vs population controls; CESC cis rs9318086 0.648 rs7331047 chr13:24467342 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.49 6.96 0.39 2.6e-11 Myopia (pathological); CESC cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg25554036 chr4:6271136 WFS1 -0.52 -8.47 -0.46 1.66e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg14893161 chr1:205819251 PM20D1 0.92 17.05 0.72 1.66e-44 Menarche (age at onset); CESC cis rs2230307 0.536 rs580678 chr1:100483009 C/A cg24955406 chr1:100503596 HIAT1 0.54 5.44 0.32 1.19e-7 Carotid intima media thickness; CESC cis rs7582720 1.000 rs114079739 chr2:203825106 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs2235642 0.893 rs2076442 chr16:1591112 G/T cg03771183 chr16:1608904 IFT140 0.41 5.9 0.34 1.1e-8 Coronary artery disease; CESC cis rs920590 0.527 rs79929516 chr8:19650050 G/C cg03894339 chr8:19674705 INTS10 0.74 7.74 0.43 2.11e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs9488822 0.597 rs12214881 chr6:116342187 G/T cg15226275 chr6:116381976 FRK 0.24 6.2 0.36 2.17e-9 Cholesterol, total;LDL cholesterol; CESC cis rs9894429 1.000 rs9894429 chr17:79596811 C/T cg13777783 chr17:79615861 NA -0.34 -5.65 -0.33 4.22e-8 Eye color traits; CESC cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg18512352 chr11:47633146 NA -0.51 -7.31 -0.41 3.18e-12 Subjective well-being; CESC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg03647317 chr4:187891568 NA -0.37 -5.37 -0.31 1.69e-7 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04742047 chr19:14544036 PKN1 -0.45 -6.0 -0.35 6.53e-9 Fibrinogen levels; CESC cis rs9318086 0.624 rs9510909 chr13:24436760 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.43 5.75 0.33 2.5e-8 Myopia (pathological); CESC cis rs2839186 0.739 rs7282763 chr21:47696800 C/T cg10351095 chr21:47802916 PCNT -0.51 -6.98 -0.39 2.36e-11 Testicular germ cell tumor; CESC cis rs4975616 0.804 rs31489 chr5:1342714 C/A cg07493874 chr5:1342172 CLPTM1L -0.42 -7.79 -0.43 1.56e-13 Lung cancer; CESC cis rs13191362 0.935 rs34603926 chr6:163266793 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.53 5.41 0.32 1.41e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3617 0.625 rs7617468 chr3:52849549 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.74 0.33 2.53e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs7631605 0.967 rs4678949 chr3:37253277 C/T cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.11 -0.3 6.25e-7 Cerebrospinal P-tau181p levels; CESC cis rs1538970 0.924 rs12037201 chr1:45941349 G/T cg06784218 chr1:46089804 CCDC17 0.35 5.64 0.33 4.32e-8 Platelet count; CESC cis rs709400 1.000 rs10135248 chr14:104122310 T/C cg12935359 chr14:103987150 CKB -0.42 -5.74 -0.33 2.6e-8 Body mass index; CESC cis rs7927771 0.965 rs4752881 chr11:47898535 A/G cg05585544 chr11:47624801 NA -0.49 -7.45 -0.42 1.34e-12 Subjective well-being; CESC cis rs8114671 0.562 rs2378292 chr20:33485178 T/C cg07148914 chr20:33460835 GGT7 0.52 6.8 0.39 6.88e-11 Height; CESC trans rs13398848 1.000 rs10496302 chr2:84210195 C/T cg23262351 chr6:79576851 IRAK1BP1 -0.69 -6.08 -0.35 4.1e-9 Conduct disorder (symptom count);Conduct disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10056854 chr16:22019337 C16orf52 0.55 6.27 0.36 1.49e-9 Gut microbiome composition (summer); CESC cis rs11638352 1.000 rs2615295 chr15:44412598 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs6964587 1.000 rs2299240 chr7:91654618 A/G cg17063962 chr7:91808500 NA 0.56 7.69 0.43 2.84e-13 Breast cancer; CESC cis rs1215050 0.740 rs783941 chr4:99008235 T/C cg17366294 chr4:99064904 C4orf37 -0.4 -5.23 -0.31 3.42e-7 Waist-to-hip ratio adjusted for body mass index; CESC trans rs916888 0.773 rs199439 chr17:44793503 A/G cg23590916 chr17:43697445 MGC57346 0.65 6.69 0.38 1.33e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2072732 0.821 rs58265521 chr1:2943398 C/A cg15211996 chr1:2936768 ACTRT2 0.35 5.74 0.33 2.65e-8 Plateletcrit; CESC trans rs1116547 0.602 rs6878001 chr5:112813100 T/C cg10115368 chr14:100435663 NA 0.5 6.1 0.35 3.68e-9 Cerebral amyloid angiopathy; CESC cis rs7091068 0.550 rs7079013 chr10:95487878 A/C cg20715218 chr10:95462985 C10orf4 0.49 6.48 0.37 4.46e-10 Urinary tract infection frequency; CESC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg07507251 chr3:52567010 NT5DC2 0.42 7.3 0.41 3.4e-12 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11328405 chr15:49170157 SHC4;EID1 0.53 7.36 0.41 2.29e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs782590 0.517 rs13013133 chr2:55889466 G/A cg18811423 chr2:55921094 PNPT1 -0.58 -7.65 -0.43 3.67e-13 Metabolic syndrome; CESC cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg16339924 chr4:17578868 LAP3 0.73 9.53 0.51 1.03e-18 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4704187 0.649 rs7717415 chr5:74558893 A/G cg03227963 chr5:74354835 NA 0.29 5.24 0.31 3.31e-7 Response to amphetamines; CESC cis rs6963495 0.769 rs117986187 chr7:105167311 G/A cg19920283 chr7:105172520 RINT1 0.7 6.68 0.38 1.39e-10 Bipolar disorder (body mass index interaction); CESC cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.24 0.31 3.24e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.49 -0.5 1.38e-18 Alzheimer's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16221875 chr6:21588597 NA 0.48 6.01 0.35 6.19e-9 Gut microbiota (bacterial taxa); CESC cis rs7202877 0.706 rs37599 chr16:75502132 C/T cg04384234 chr16:75411784 CFDP1 0.44 5.29 0.31 2.56e-7 Type 2 diabetes;Type 1 diabetes; CESC cis rs11252926 0.501 rs2050971 chr10:525530 T/G cg16386425 chr10:429943 DIP2C 0.41 5.04 0.3 8.76e-7 Psychosis in Alzheimer's disease; CESC cis rs9329289 0.851 rs61835719 chr10:2543390 A/G cg15501526 chr10:2543763 NA 0.64 11.38 0.57 1.1e-24 Age-related hearing impairment; CESC cis rs1784581 0.588 rs7758559 chr6:162438635 G/T cg17173639 chr6:162384350 PARK2 0.55 8.25 0.45 7.24e-15 Itch intensity from mosquito bite; CESC cis rs728616 0.614 rs12411833 chr10:82103230 T/C cg05935833 chr10:81318306 SFTPA2 -0.37 -5.31 -0.31 2.3e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs7902708 0.920 rs12258467 chr10:54423900 C/T cg26219051 chr22:43739629 SCUBE1 -0.48 -6.19 -0.36 2.25e-9 Bone properties (heel); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04482943 chr17:26684713 TMEM199;POLDIP2 0.63 7.02 0.4 1.87e-11 Gut microbiome composition (summer); CESC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 9.09 0.49 2.43e-17 Platelet count; CESC cis rs798766 1.000 rs1665366 chr4:1728381 A/G cg05874882 chr4:1763078 NA 0.6 7.67 0.43 3.35e-13 Bladder cancer;Urinary bladder cancer; CESC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg24634471 chr8:143751801 JRK -0.44 -5.29 -0.31 2.6e-7 Urinary tract infection frequency; CESC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg08888203 chr3:10149979 C3orf24 0.53 6.67 0.38 1.51e-10 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09071838 chr13:25497213 CENPJ 0.6 7.14 0.4 8.79e-12 Gut microbiome composition (summer); CESC cis rs796364 1.000 rs281794 chr2:200846666 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.89 8.77 0.47 2.23e-16 Schizophrenia; CESC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg17724175 chr1:150552817 MCL1 0.39 5.96 0.34 8.12e-9 Melanoma; CESC cis rs2228479 0.702 rs62053701 chr16:89860584 G/A cg04013166 chr16:89971882 TCF25 0.77 6.61 0.38 2.05e-10 Skin colour saturation; CESC cis rs35995292 0.500 rs8180877 chr7:38931258 G/A cg19327137 chr7:38886074 VPS41 0.67 11.01 0.56 1.76e-23 Subjective well-being (multi-trait analysis); CESC cis rs11098499 0.954 rs10008392 chr4:120318839 G/A cg24375607 chr4:120327624 NA 0.48 5.81 0.34 1.8e-8 Corneal astigmatism; CESC cis rs7089973 0.604 rs17663387 chr10:116588060 C/G cg23260525 chr10:116636907 FAM160B1 0.38 7.08 0.4 1.29e-11 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17676428 chr11:1314042 TOLLIP -0.55 -6.06 -0.35 4.71e-9 Gut microbiome composition (summer); CESC cis rs2274273 0.638 rs9919921 chr14:55695505 A/G cg04306507 chr14:55594613 LGALS3 0.31 5.25 0.31 3.2e-7 Protein biomarker; CESC cis rs820218 0.743 rs820233 chr17:73697391 C/T cg01592526 chr17:73663357 RECQL5;SAP30BP 0.41 5.6 0.33 5.26e-8 Rotator cuff tears; CESC cis rs854765 0.505 rs4506969 chr17:17899839 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.5 6.45 0.37 5.32e-10 Total body bone mineral density; CESC cis rs881375 0.715 rs11794516 chr9:123640230 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 7.12 0.4 1.01e-11 Rheumatoid arthritis; CESC cis rs34779708 0.702 rs7087150 chr10:35542138 A/T cg04310649 chr10:35416472 CREM -0.47 -5.39 -0.31 1.59e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg27535305 chr1:53392650 SCP2 0.31 5.51 0.32 8.35e-8 Monocyte count; CESC cis rs36051895 0.560 rs10975009 chr9:5220397 T/G cg02405213 chr9:5042618 JAK2 -0.5 -6.09 -0.35 4.01e-9 Pediatric autoimmune diseases; CESC cis rs8044868 0.530 rs4788464 chr16:72223899 T/C cg16558253 chr16:72132732 DHX38 -0.43 -6.68 -0.38 1.37e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg00149659 chr3:10157352 C3orf10 1.0 11.96 0.59 1.22e-26 Alzheimer's disease; CESC cis rs10979 1.000 rs9399447 chr6:143896163 T/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.66e-17 Hypospadias; CESC cis rs9796 0.870 rs3900905 chr15:41260801 G/A cg18705301 chr15:41695430 NDUFAF1 0.42 6.24 0.36 1.74e-9 Menopause (age at onset); CESC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.81 -0.34 1.77e-8 Total body bone mineral density; CESC cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg11952622 chr19:58962976 ZNF324B -0.47 -6.56 -0.37 2.83e-10 Uric acid clearance; CESC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.61 6.87 0.39 4.67e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7249142 0.597 rs7250650 chr19:19285989 A/T cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.29 5.21 0.3 3.75e-7 IgG glycosylation; CESC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg04267008 chr7:1944627 MAD1L1 -0.74 -9.86 -0.52 1.01e-19 Bipolar disorder and schizophrenia; CESC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg08859206 chr1:53392774 SCP2 -0.54 -6.98 -0.39 2.34e-11 Monocyte count; CESC cis rs8062405 0.755 rs12447461 chr16:28582941 C/A cg01378222 chr16:28622494 SULT1A1 0.31 5.3 0.31 2.49e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6463523 0.898 rs66892628 chr7:759374 T/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.97 14.68 0.67 4.26e-36 Subjective well-being; CESC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg11764359 chr7:65958608 NA 0.82 9.61 0.51 6.13e-19 Aortic root size; CESC cis rs2115536 0.720 rs12916091 chr15:80222572 T/G cg00225070 chr15:80189496 MTHFS 0.42 5.56 0.32 6.65e-8 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs4268898 0.552 rs12620938 chr2:24367122 C/A cg06627628 chr2:24431161 ITSN2 0.59 8.19 0.45 1.12e-14 Asthma; CESC cis rs10028773 0.700 rs7671797 chr4:120248157 A/G cg09307838 chr4:120376055 NA 0.78 10.54 0.54 6.4e-22 Educational attainment; CESC cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg18512352 chr11:47633146 NA -0.52 -7.51 -0.42 9.24e-13 Subjective well-being; CESC cis rs7116495 1.000 rs2511079 chr11:71804154 C/T cg26138937 chr11:71823887 C11orf51 -0.86 -7.72 -0.43 2.38e-13 Severe influenza A (H1N1) infection; CESC cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg17211192 chr8:82754475 SNX16 0.7 8.32 0.46 4.71e-15 Diastolic blood pressure; CESC cis rs4243830 0.522 rs10157142 chr1:6618785 A/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.87 -8.13 -0.45 1.61e-14 Body mass index; CESC cis rs3767633 0.925 rs2298019 chr1:161736035 A/G cg09175582 chr1:161736000 ATF6 0.83 6.17 0.35 2.53e-9 IgG glycosylation; CESC cis rs1580019 0.587 rs7806941 chr7:32553319 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.69 0.38 1.33e-10 Cognitive ability; CESC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.95 10.92 0.56 3.71e-23 Platelet count; CESC cis rs6714710 0.603 rs2044458 chr2:98377512 A/T cg26665480 chr2:98280029 ACTR1B 0.53 7.58 0.42 5.78e-13 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg14829155 chr15:31115871 NA -0.72 -9.68 -0.51 3.49e-19 Huntington's disease progression; CESC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.23 0.31 3.42e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6580649 0.771 rs1034762 chr12:48389643 G/T cg05342945 chr12:48394962 COL2A1 0.53 6.34 0.36 9.69e-10 Lung cancer; CESC cis rs11098499 0.644 rs34835603 chr4:120553428 C/T cg09307838 chr4:120376055 NA 0.78 10.46 0.54 1.13e-21 Corneal astigmatism; CESC cis rs5743618 0.537 rs10020220 chr4:38765867 A/G cg02016764 chr4:38805732 TLR1 -0.34 -5.21 -0.3 3.84e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs1800795 0.652 rs7802307 chr7:22766433 T/A cg05472934 chr7:22766657 IL6 0.78 10.14 0.53 1.27e-20 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CESC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg13114125 chr14:105738426 BRF1 -0.81 -9.76 -0.51 1.95e-19 Mean platelet volume;Platelet distribution width; CESC cis rs933688 0.532 rs2973477 chr5:90553722 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.44 -5.11 -0.3 6.1e-7 Smoking behavior; CESC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg05368731 chr17:41323189 NBR1 0.75 10.35 0.54 2.72e-21 Menopause (age at onset); CESC trans rs9325144 0.560 rs11183150 chr12:38674698 A/G cg23762105 chr12:34175262 ALG10 0.48 6.29 0.36 1.32e-9 Morning vs. evening chronotype; CESC cis rs763121 0.853 rs2235230 chr22:39124467 A/G cg06022373 chr22:39101656 GTPBP1 -0.86 -12.72 -0.62 3.04e-29 Menopause (age at onset); CESC cis rs17818399 0.788 rs17818315 chr2:46818992 C/T cg06386533 chr2:46925753 SOCS5 0.48 5.46 0.32 1.08e-7 Height; CESC cis rs9811920 0.609 rs4928232 chr3:99694217 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.61 -7.37 -0.41 2.19e-12 Axial length; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17847749 chr12:116355168 NA 0.46 6.27 0.36 1.49e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg02951883 chr7:2050386 MAD1L1 -0.47 -6.01 -0.35 6.14e-9 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09574498 chr17:48944758 NA -0.67 -7.63 -0.42 4.14e-13 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs7753696 chr6:146279098 G/T cg05347473 chr6:146136440 FBXO30 -0.58 -7.35 -0.41 2.39e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs8072100 0.744 rs34537623 chr17:45530203 A/G cg08085267 chr17:45401833 C17orf57 -0.54 -7.28 -0.41 3.75e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs10927875 0.541 rs1763607 chr1:16337509 G/A cg22431228 chr1:16359049 CLCNKA -0.52 -9.99 -0.52 3.63e-20 Dilated cardiomyopathy; CESC cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg22800045 chr5:56110881 MAP3K1 -0.59 -7.58 -0.42 5.95e-13 Initial pursuit acceleration; CESC cis rs9487051 0.768 rs371960 chr6:109525082 A/G cg01475377 chr6:109611718 NA -0.48 -7.45 -0.42 1.34e-12 Reticulocyte fraction of red cells; CESC cis rs1707322 0.963 rs4660900 chr1:46419605 T/C cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs875971 0.895 rs1833495 chr7:65921595 T/C cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs5769765 0.865 rs3788730 chr22:50244695 C/T cg26441486 chr22:50317300 CRELD2 -0.4 -5.52 -0.32 8.04e-8 Schizophrenia; CESC trans rs7618501 0.633 rs4688690 chr3:50022292 G/A cg21659725 chr3:3221576 CRBN 0.54 7.55 0.42 7.09e-13 Intelligence (multi-trait analysis); CESC cis rs9682041 0.808 rs9880558 chr3:170067771 A/G cg11886554 chr3:170076028 SKIL -0.57 -5.47 -0.32 1.05e-7 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs7191868 1 rs7191868 chr16:536090 G/C cg00676925 chr16:540266 RAB11FIP3 -0.64 -7.34 -0.41 2.55e-12 Platelet distribution width; CESC cis rs7219021 0.739 rs1973404 chr17:46967892 G/T cg16584676 chr17:46985605 UBE2Z -0.65 -7.82 -0.43 1.24e-13 Schizophrenia or bipolar disorder; CESC cis rs4969178 0.965 rs8071889 chr17:76398101 A/G cg05887092 chr17:76393375 PGS1 0.58 9.08 0.49 2.62e-17 HDL cholesterol levels; CESC trans rs61931739 0.534 rs4931772 chr12:34044590 G/A cg26384229 chr12:38710491 ALG10B 0.53 7.22 0.41 5.44e-12 Morning vs. evening chronotype; CESC cis rs3824867 0.920 rs7130693 chr11:47452321 T/C cg20307385 chr11:47447363 PSMC3 -0.49 -5.94 -0.34 9.16e-9 Mean corpuscular hemoglobin; CESC cis rs763014 0.898 rs1981484 chr16:630710 A/G cg07343612 chr16:622815 PIGQ -0.58 -8.49 -0.46 1.53e-15 Height; CESC cis rs6088590 1.000 rs2076668 chr20:33437621 G/A cg24642439 chr20:33292090 TP53INP2 0.82 11.56 0.58 2.76e-25 Coronary artery disease; CESC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg09913183 chr17:42254507 C17orf65;ASB16 0.68 9.08 0.49 2.61e-17 Total body bone mineral density; CESC cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.33 0.6 6.31e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04104609 chr2:219523980 ZNF142;BCS1L 0.52 6.18 0.35 2.45e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12317515 chr5:74063363 GFM2;NSA2 0.5 6.93 0.39 3.29e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.56 0.54 5.51e-22 Prudent dietary pattern; CESC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.53 0.37 3.4e-10 Prudent dietary pattern; CESC cis rs854765 0.583 rs4534911 chr17:17852330 A/G cg09796270 chr17:17721594 SREBF1 0.49 6.66 0.38 1.56e-10 Total body bone mineral density; CESC cis rs9911578 0.967 rs2643124 chr17:56741672 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.24 0.31 3.23e-7 Intelligence (multi-trait analysis); CESC cis rs250677 0.958 rs36078 chr5:148430567 G/A cg18129178 chr5:148520854 ABLIM3 -0.52 -5.46 -0.32 1.1e-7 Breast cancer; CESC cis rs6991838 0.584 rs7812446 chr8:66505988 G/T cg13398993 chr8:66546079 ARMC1 -0.47 -5.59 -0.32 5.56e-8 Intelligence (multi-trait analysis); CESC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg07332563 chr6:291687 DUSP22 -0.7 -9.24 -0.49 8.36e-18 Menopause (age at onset); CESC cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg11366901 chr6:160182831 ACAT2 0.84 10.74 0.55 1.47e-22 Age-related macular degeneration (geographic atrophy); CESC cis rs208520 0.909 rs60604603 chr6:67022955 T/C cg07460842 chr6:66804631 NA 0.84 8.13 0.45 1.67e-14 Exhaled nitric oxide output; CESC trans rs11039798 0.614 rs2174703 chr11:48788242 G/A cg15704280 chr7:45808275 SEPT13 0.71 6.22 0.36 1.92e-9 Axial length; CESC cis rs3768617 0.565 rs2027080 chr1:183074415 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Fuchs's corneal dystrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11179286 chr13:115047994 UPF3A 0.59 7.31 0.41 3.16e-12 Gut microbiome composition (summer); CESC cis rs2191566 1.000 rs10418363 chr19:44525463 A/G cg20607764 chr19:44506953 ZNF230 -0.57 -7.45 -0.42 1.3e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs67460515 0.506 rs935497 chr3:160600563 A/G cg03342759 chr3:160939853 NMD3 -0.48 -6.32 -0.36 1.09e-9 Parkinson's disease; CESC cis rs6867032 1.000 rs4246753 chr5:2014721 G/A cg26168224 chr5:2018326 NA 0.95 19.19 0.76 4.89e-52 Gut microbiome composition (winter); CESC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC trans rs11055612 0.776 rs1075010 chr12:13918341 T/C cg23361084 chr11:73309262 FAM168A -0.47 -6.02 -0.35 5.92e-9 Brain structure (temporal lobe volume); CESC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg23758822 chr17:41437982 NA 1.04 15.41 0.69 1.12e-38 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27536708 chr12:21654836 RECQL;GOLT1B -0.55 -6.11 -0.35 3.52e-9 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.64 0.47 5.5e-16 Menopause (age at onset); CESC cis rs965469 0.901 rs6037563 chr20:3326568 G/A cg25506879 chr20:3388711 C20orf194 -0.54 -5.78 -0.33 2.14e-8 IFN-related cytopenia; CESC cis rs8060686 0.920 rs73591961 chr16:67801309 G/A cg26727032 chr16:67993705 SLC12A4 -0.57 -6.06 -0.35 4.61e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs12477438 1.000 rs11897712 chr2:99735697 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -8.6 -0.47 6.98e-16 Chronic sinus infection; CESC cis rs7551222 0.752 rs1380576 chr1:204488278 G/C cg20240347 chr1:204465584 NA -0.28 -5.66 -0.33 3.95e-8 Schizophrenia; CESC cis rs1801251 1.000 rs2592102 chr2:233726772 G/T cg25237894 chr2:233734115 C2orf82 -0.47 -8.1 -0.45 1.98e-14 Coronary artery disease; CESC cis rs2412819 0.542 rs62018894 chr15:43912987 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.52 6.68 0.38 1.41e-10 Lung cancer; CESC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg10691866 chr7:65817282 TPST1 0.33 5.39 0.31 1.58e-7 Aortic root size; CESC cis rs7762018 0.941 rs4716387 chr6:170136777 G/C cg05834625 chr6:170176447 C6orf70 0.62 7.13 0.4 9.56e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1707322 0.826 rs10890349 chr1:46249955 T/C cg03146154 chr1:46216737 IPP 0.81 11.3 0.57 1.99e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg18538332 chr22:24372958 LOC391322 0.69 9.99 0.52 3.71e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg07115559 chr11:122932847 HSPA8 0.43 6.48 0.37 4.4e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2985684 0.789 rs7161649 chr14:50064028 A/G cg02151108 chr14:50098012 C14orf104 -0.38 -5.03 -0.3 8.89e-7 Carotid intima media thickness; CESC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg04169830 chr2:88471460 THNSL2 0.33 5.13 0.3 5.52e-7 Response to metformin (IC50); CESC cis rs3105593 0.575 rs3098174 chr15:50778853 C/T cg05456662 chr15:50716270 USP8 0.45 6.05 0.35 5.04e-9 QT interval; CESC cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg24308560 chr3:49941425 MST1R 0.58 8.38 0.46 3.11e-15 Body mass index; CESC cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg18512352 chr11:47633146 NA -0.52 -7.58 -0.42 5.86e-13 Subjective well-being; CESC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg17376030 chr22:41985996 PMM1 0.76 8.22 0.45 9.05e-15 Vitiligo; CESC cis rs4474465 0.850 rs10899549 chr11:78255389 T/C cg27205649 chr11:78285834 NARS2 0.42 5.32 0.31 2.16e-7 Alzheimer's disease (survival time); CESC cis rs6582630 0.502 rs10880092 chr12:38262965 A/T cg13010199 chr12:38710504 ALG10B 0.51 6.29 0.36 1.29e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7927771 0.757 rs1057233 chr11:47376448 G/A cg18512352 chr11:47633146 NA 0.51 7.17 0.4 7.32e-12 Subjective well-being; CESC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg00310523 chr12:86230176 RASSF9 0.35 5.49 0.32 9.32e-8 Major depressive disorder; CESC cis rs559555 0.812 rs3754835 chr2:32206029 T/G cg02381751 chr2:32503542 YIPF4 0.42 5.34 0.31 1.96e-7 Blood metabolite ratios;Blood metabolite levels; CESC cis rs950776 0.518 rs4886572 chr15:78837452 A/G cg24631222 chr15:78858424 CHRNA5 0.39 5.12 0.3 6.02e-7 Sudden cardiac arrest; CESC cis rs12701220 0.744 rs2030958 chr7:1076010 G/T cg26769984 chr7:1090371 C7orf50 0.68 7.72 0.43 2.34e-13 Bronchopulmonary dysplasia; CESC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg16325326 chr1:53192061 ZYG11B -0.9 -15.33 -0.69 2.02e-38 Monocyte count; CESC cis rs6963495 0.818 rs117907809 chr7:105168472 C/A cg13798780 chr7:105162888 PUS7 0.76 7.72 0.43 2.36e-13 Bipolar disorder (body mass index interaction); CESC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs35146811 0.844 rs34031156 chr7:99677917 T/A cg22906224 chr7:99728672 NA 0.42 5.19 0.3 4.12e-7 Coronary artery disease; CESC cis rs3091242 0.933 rs909833 chr1:25754140 C/G cg02931644 chr1:25747376 RHCE 0.38 6.37 0.36 8.43e-10 Erythrocyte sedimentation rate; CESC cis rs6121246 0.909 rs6060960 chr20:30394517 G/T cg13852791 chr20:30311386 BCL2L1 -0.75 -8.41 -0.46 2.48e-15 Mean corpuscular hemoglobin; CESC cis rs796364 0.951 rs7586284 chr2:201068002 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.61 5.71 0.33 3.07e-8 Schizophrenia; CESC cis rs10191773 0.535 rs72833432 chr2:113102746 T/C cg24977338 chr2:113188963 RGPD8;RGPD5 -0.61 -6.37 -0.36 8.21e-10 Yeast infection; CESC trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -20.77 -0.79 1.6e-57 Height; CESC cis rs8014204 0.604 rs11625594 chr14:75389833 G/A cg11812906 chr14:75593930 NEK9 0.54 6.67 0.38 1.48e-10 Caffeine consumption; CESC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg12463550 chr7:65579703 CRCP 0.47 5.79 0.34 1.99e-8 Aortic root size; CESC cis rs2637266 0.783 rs846633 chr10:78535744 A/C cg18941641 chr10:78392320 NA -0.38 -7.33 -0.41 2.81e-12 Pulmonary function; CESC cis rs7918232 0.943 rs4747584 chr10:27373333 G/A cg14240646 chr10:27532245 ACBD5 -0.67 -6.24 -0.36 1.75e-9 Breast cancer; CESC cis rs11871801 1.000 rs57307201 chr17:40572793 G/A cg21433558 chr17:40837037 CNTNAP1 0.45 5.04 0.3 8.46e-7 Crohn's disease; CESC cis rs9916302 0.718 rs7219909 chr17:37706243 C/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs3824867 0.920 rs7105907 chr11:47450318 A/T cg20307385 chr11:47447363 PSMC3 -0.47 -5.48 -0.32 9.68e-8 Mean corpuscular hemoglobin; CESC cis rs735860 0.687 rs2294852 chr6:53157214 C/G cg10236188 chr6:53219634 NA -0.35 -5.04 -0.3 8.74e-7 Glaucoma; CESC cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1046896 1.000 rs9909940 chr17:80689036 C/T cg02711726 chr17:80685570 FN3KRP -0.56 -8.27 -0.45 6.53e-15 Glycated hemoglobin levels; CESC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.39e-30 Prudent dietary pattern; CESC cis rs950027 0.787 rs1153845 chr15:45724729 C/T cg21132104 chr15:45694354 SPATA5L1 -0.48 -5.81 -0.34 1.82e-8 Response to fenofibrate (adiponectin levels); CESC cis rs2115536 0.730 rs4573897 chr15:80187225 G/A cg00225070 chr15:80189496 MTHFS 0.48 6.49 0.37 4.22e-10 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC trans rs4843747 0.641 rs11117353 chr16:88090895 A/G cg26811252 chr16:29126840 RRN3P2 0.7 9.85 0.52 1.02e-19 Menopause (age at onset); CESC cis rs56235845 0.694 rs6875461 chr5:176754665 C/T cg06060754 chr5:176797920 RGS14 -0.44 -5.6 -0.33 5.28e-8 Hemoglobin concentration;Hematocrit; CESC cis rs11264213 0.901 rs683622 chr1:36443569 C/T cg27506609 chr1:36549197 TEKT2 -0.43 -5.03 -0.3 8.9e-7 Schizophrenia; CESC cis rs4604732 0.588 rs7552461 chr1:247628644 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 6.01 0.35 6.07e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg03709012 chr19:19516395 GATAD2A 1.01 15.9 0.7 1.97e-40 Tonsillectomy; CESC trans rs10448044 1.000 rs7820287 chr8:80100004 G/C cg08211306 chr6:46097784 ENPP4 0.42 6.02 0.35 5.87e-9 Suicide in bipolar disorder; CESC cis rs854765 0.583 rs12603148 chr17:17865257 C/T cg04398451 chr17:18023971 MYO15A -0.72 -10.46 -0.54 1.13e-21 Total body bone mineral density; CESC cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg05347473 chr6:146136440 FBXO30 0.59 7.63 0.42 4.24e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs11077998 0.933 rs4239021 chr17:80531826 T/C cg10255544 chr17:80519551 FOXK2 0.55 8.73 0.47 2.83e-16 Reticulocyte fraction of red cells; CESC cis rs9911578 0.967 rs2333410 chr17:57137129 G/A cg05425664 chr17:57184151 TRIM37 0.51 7.03 0.4 1.77e-11 Intelligence (multi-trait analysis); CESC cis rs9303280 0.868 rs11650661 chr17:38026286 A/T cg20243544 chr17:37824526 PNMT 0.53 7.05 0.4 1.57e-11 Self-reported allergy; CESC trans rs9858542 0.953 rs6997 chr3:49453834 C/T cg21659725 chr3:3221576 CRBN -0.53 -6.74 -0.38 9.95e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs3008870 0.755 rs2755242 chr1:67479598 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.62 8.04 0.44 3.01e-14 Lymphocyte percentage of white cells; CESC cis rs524281 0.861 rs10896077 chr11:65851733 C/G cg14036092 chr11:66035641 RAB1B -0.62 -6.39 -0.37 7.55e-10 Electroencephalogram traits; CESC cis rs2011503 1.000 rs4808206 chr19:19645645 C/A cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.12 0.3 5.77e-7 Bipolar disorder; CESC cis rs7084402 1.000 rs36097682 chr10:60269738 G/A cg07615347 chr10:60278583 BICC1 -0.57 -8.71 -0.47 3.43e-16 Refractive error; CESC cis rs72945132 0.882 rs56368190 chr11:70204328 T/G cg14191688 chr11:70257035 CTTN 0.41 5.12 0.3 6.02e-7 Coronary artery disease; CESC cis rs6732160 0.774 rs1367291 chr2:73374865 A/T cg01422370 chr2:73384389 NA 0.43 7.47 0.42 1.16e-12 Intelligence (multi-trait analysis); CESC cis rs748404 0.587 rs690276 chr15:43704558 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.59 7.78 0.43 1.67e-13 Lung cancer; CESC cis rs5753618 0.583 rs5749268 chr22:31809152 G/A cg13145458 chr22:31556086 RNF185 -0.5 -5.96 -0.34 7.96e-9 Colorectal cancer; CESC cis rs1003719 0.762 rs3787786 chr21:38463436 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC trans rs17685 0.753 rs7804598 chr7:75702578 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 11.96 0.59 1.23e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs6991838 0.584 rs6472218 chr8:66547737 G/C cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs793571 0.590 rs618684 chr15:59115922 A/G cg05156742 chr15:59063176 FAM63B 0.6 7.81 0.43 1.3e-13 Schizophrenia; CESC cis rs2370759 0.891 rs11592754 chr10:32619572 A/C cg01819863 chr10:32635814 EPC1 1.12 10.05 0.53 2.45e-20 Sexual dysfunction (female); CESC cis rs3768617 0.510 rs1886500 chr1:183095048 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs1499972 0.941 rs1456182 chr3:117659680 C/T cg07612923 chr3:117604196 NA 0.91 7.88 0.44 8.41e-14 Schizophrenia; CESC cis rs3818285 0.679 rs612155 chr10:111630731 C/G cg00817464 chr10:111662876 XPNPEP1 0.48 7.53 0.42 7.85e-13 Superior crus of antihelix expression; CESC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg03705947 chr1:68152081 GADD45A -0.45 -6.22 -0.36 1.89e-9 Height; CESC cis rs116095464 0.558 rs55776650 chr5:273826 G/A cg22496380 chr5:211416 CCDC127 -0.75 -8.59 -0.47 7.5e-16 Breast cancer; CESC cis rs854765 0.647 rs6502637 chr17:17986098 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 6.01 0.35 6.26e-9 Total body bone mineral density; CESC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg04414720 chr1:150670196 GOLPH3L 0.63 9.04 0.49 3.47e-17 Tonsillectomy; CESC cis rs2191566 0.576 rs381628 chr19:44494333 T/C cg20607764 chr19:44506953 ZNF230 0.45 5.74 0.33 2.57e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs17407555 0.601 rs73229828 chr4:10026833 A/G cg11266682 chr4:10021025 SLC2A9 -0.5 -5.94 -0.34 8.82e-9 Schizophrenia (age at onset); CESC cis rs938554 0.779 rs9998811 chr4:9966477 G/A cg00071950 chr4:10020882 SLC2A9 -0.45 -5.24 -0.31 3.36e-7 Blood metabolite levels; CESC cis rs400736 0.930 rs226251 chr1:8024690 T/C cg25007680 chr1:8021821 PARK7 0.72 10.17 0.53 1.02e-20 Response to antidepressants and depression; CESC cis rs1568889 0.838 rs10835276 chr11:28167147 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.45 0.64 8.35e-32 Bipolar disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10078639 chr10:116286586 ABLIM1 -0.46 -6.12 -0.35 3.31e-9 Ulcerative colitis; CESC cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg21395723 chr22:39101663 GTPBP1 0.43 5.28 0.31 2.76e-7 Menopause (age at onset); CESC cis rs858239 0.636 rs28706766 chr7:23169834 T/A cg27449745 chr7:23145252 KLHL7 -0.49 -6.38 -0.36 7.81e-10 Cerebrospinal fluid biomarker levels; CESC cis rs9814567 1.000 rs4309773 chr3:134277301 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.08 -0.35 4.19e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs3942852 0.568 rs10769314 chr11:48097620 C/T cg03929089 chr4:120376271 NA -0.63 -7.77 -0.43 1.78e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg24060327 chr5:131705240 SLC22A5 -0.47 -6.08 -0.35 4.12e-9 Acylcarnitine levels; CESC cis rs4727963 0.792 rs12665913 chr7:122741302 T/C cg03640110 chr7:122635026 TAS2R16 0.4 6.14 0.35 3.08e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg04944784 chr2:26401820 FAM59B -0.67 -7.53 -0.42 8.08e-13 Gut microbiome composition (summer); CESC cis rs17209837 0.915 rs17149660 chr7:87089524 T/C cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC cis rs778371 0.788 rs4973569 chr2:233767037 A/G cg08000102 chr2:233561755 GIGYF2 -0.81 -11.03 -0.56 1.53e-23 Schizophrenia; CESC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg12963246 chr6:28129442 ZNF389 0.43 6.25 0.36 1.59e-9 Cardiac Troponin-T levels; CESC cis rs712039 0.652 rs853222 chr17:35790022 G/T cg16670864 chr17:35848621 DUSP14 0.44 5.38 0.31 1.63e-7 Tuberculosis; CESC cis rs17376456 0.866 rs13356088 chr5:93423479 C/T cg25358565 chr5:93447407 FAM172A 1.22 10.91 0.56 3.85e-23 Diabetic retinopathy; CESC cis rs7553864 0.667 rs10873820 chr1:87605973 C/G cg17420885 chr1:87600446 LOC339524 0.41 5.5 0.32 9.08e-8 Smoking behavior; CESC cis rs360798 0.532 rs360799 chr2:62953166 G/A cg17519650 chr2:63277830 OTX1 -0.6 -7.71 -0.43 2.6e-13 Coronary artery disease; CESC cis rs1062177 1.000 rs6890099 chr5:151151962 A/G cg00977110 chr5:151150581 G3BP1 0.67 7.07 0.4 1.4e-11 Preschool internalizing problems; CESC cis rs7937682 0.883 rs542831 chr11:111471392 T/A cg22437258 chr11:111473054 SIK2 0.73 9.56 0.51 8.27e-19 Primary sclerosing cholangitis; CESC cis rs7772486 0.686 rs10872579 chr6:145966012 C/G cg05347473 chr6:146136440 FBXO30 0.46 5.96 0.34 8.21e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs2933343 0.700 rs789233 chr3:128603150 G/T cg24203234 chr3:128598194 ACAD9 0.45 6.16 0.35 2.63e-9 IgG glycosylation; CESC cis rs1797885 0.836 rs74280679 chr3:12570986 T/C cg26432171 chr3:12704882 RAF1 -0.47 -5.94 -0.34 9.04e-9 Immature fraction of reticulocytes; CESC cis rs992157 0.732 rs10932771 chr2:219170236 A/T cg00012203 chr2:219082015 ARPC2 0.74 9.93 0.52 5.65e-20 Colorectal cancer; CESC trans rs11098499 0.913 rs10010696 chr4:120164303 T/C cg25214090 chr10:38739885 LOC399744 0.63 8.26 0.45 7.19e-15 Corneal astigmatism; CESC cis rs77106637 0.929 rs74333814 chr11:72457487 C/T cg03713592 chr11:72463424 ARAP1 1.3 11.05 0.56 1.39e-23 Type 2 diabetes; CESC trans rs1814175 0.669 rs12416837 chr11:49669761 G/T cg03929089 chr4:120376271 NA -0.73 -9.66 -0.51 4.28e-19 Height; CESC cis rs10876993 0.928 rs1689594 chr12:58057156 T/C cg18357645 chr12:58087776 OS9 0.63 10.22 0.53 7.1e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg05863683 chr7:1912471 MAD1L1 0.43 6.35 0.36 9.24e-10 Bipolar disorder and schizophrenia; CESC cis rs9814567 1.000 rs4974493 chr3:134219993 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.46 -6.28 -0.36 1.37e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2737618 0.674 rs2737684 chr1:200092951 C/T cg21825944 chr1:200113062 NR5A2 -0.43 -6.43 -0.37 5.84e-10 Uric acid levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25201980 chr8:146127417 ZNF250 -0.47 -7.13 -0.4 9.83e-12 Gambling; CESC cis rs3740540 0.530 rs10751598 chr10:126290951 A/G cg04949429 chr10:126290192 LHPP -0.4 -5.56 -0.32 6.62e-8 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CESC cis rs1355223 0.583 rs2915178 chr11:34878051 C/T cg11058730 chr11:34937778 PDHX;APIP 0.82 12.56 0.61 1.07e-28 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9527 0.590 rs7087040 chr10:104799668 G/A cg04362960 chr10:104952993 NT5C2 0.43 5.56 0.32 6.7e-8 Arsenic metabolism; CESC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg06456125 chr7:65229604 NA 0.44 5.75 0.33 2.47e-8 Aortic root size; CESC cis rs12200560 0.505 rs9400167 chr6:97077192 G/T cg06623918 chr6:96969491 KIAA0776 0.5 6.42 0.37 6.42e-10 Coronary heart disease; CESC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg24562669 chr7:97807699 LMTK2 0.48 6.8 0.39 6.74e-11 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18955698 chr17:43025023 KIF18B -0.59 -6.95 -0.39 2.9100000000000002e-11 Gut microbiome composition (summer); CESC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg21724239 chr8:58056113 NA 0.64 5.91 0.34 1.05e-8 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.87 0.39 4.56e-11 Bipolar disorder; CESC cis rs6783573 0.965 rs7650998 chr3:46607255 C/T cg27371741 chr3:46619158 LRRC2;TDGF1 0.31 5.25 0.31 3.17e-7 Cerebrospinal fluid biomarker levels; CESC cis rs12291225 0.645 rs3763950 chr11:14278049 T/A cg19336497 chr11:14380999 RRAS2 -0.4 -5.74 -0.33 2.64e-8 Sense of smell; CESC cis rs3733585 0.753 rs1122141 chr4:9947278 T/C cg11266682 chr4:10021025 SLC2A9 -0.6 -12.03 -0.59 7.11e-27 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8072100 1.000 rs11650372 chr17:45721795 G/A cg08085267 chr17:45401833 C17orf57 -0.43 -5.67 -0.33 3.64e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2295499 0.754 rs1828803 chr4:2689449 C/A cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.04 -0.3 8.74e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12721145 chr4:109571876 OSTC 0.51 7.23 0.41 5.15e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs6780666 0.509 rs9838168 chr3:136963967 C/T cg16900796 chr19:10755136 SLC44A2 -0.4 -6.14 -0.35 3.05e-9 Intelligence (multi-trait analysis); CESC cis rs9788682 0.747 rs2938671 chr15:78732754 A/G cg24631222 chr15:78858424 CHRNA5 -0.63 -7.44 -0.42 1.44e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs1355223 0.902 rs860712 chr11:34743494 C/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.44 -0.37 5.45e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6867032 0.958 rs4505990 chr5:2015811 A/G cg26168224 chr5:2018326 NA 0.96 19.55 0.77 2.72e-53 Gut microbiome composition (winter); CESC cis rs12142240 0.698 rs6429599 chr1:46827871 G/A cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.12e-9 Menopause (age at onset); CESC cis rs2953145 0.568 rs1133354 chr2:241522450 A/G cg07929629 chr2:241523174 NA 0.67 9.46 0.5 1.8e-18 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05934196 chr8:22925766 TNFRSF10B -0.38 -6.07 -0.35 4.49e-9 Gambling; CESC cis rs5747327 0.839 rs1470341 chr22:18198109 G/A cg19898043 chr22:18121309 BCL2L13 -0.4 -5.14 -0.3 5.21e-7 Myeloid white cell count;Granulocyte count; CESC cis rs6582630 0.519 rs11181998 chr12:38439970 C/A cg26384229 chr12:38710491 ALG10B 0.69 10.55 0.54 5.83e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg19592336 chr6:28129416 ZNF389 0.55 7.11 0.4 1.06e-11 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26494424 chr12:124118326 EIF2B1;GTF2H3 0.61 6.99 0.39 2.19e-11 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg07677032 chr17:61819896 STRADA 0.45 5.93 0.34 9.64e-9 Prudent dietary pattern; CESC cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg15485101 chr11:133734466 NA 0.41 6.57 0.37 2.66e-10 Childhood ear infection; CESC cis rs12438659 1 rs12438659 chr15:78824924 G/A cg06917634 chr15:78832804 PSMA4 -0.59 -6.98 -0.39 2.32e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg05332525 chr7:65337924 VKORC1L1 -0.49 -6.05 -0.35 5.03e-9 Aortic root size; CESC cis rs897984 0.683 rs12447534 chr16:30804257 C/T cg02466173 chr16:30829666 NA 0.59 11.13 0.56 7.43e-24 Dementia with Lewy bodies; CESC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg26354017 chr1:205819088 PM20D1 0.52 6.84 0.39 5.6e-11 Menarche (age at onset); CESC cis rs7809950 1.000 rs7782057 chr7:107098877 T/A cg23024343 chr7:107201750 COG5 -0.41 -5.78 -0.33 2.12e-8 Coronary artery disease; CESC cis rs2839186 0.585 rs2839154 chr21:47637760 C/T cg10351095 chr21:47802916 PCNT 0.41 5.32 0.31 2.26e-7 Testicular germ cell tumor; CESC cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -7.89 -0.44 8.05e-14 Personality dimensions; CESC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg01988459 chr11:68622903 NA -0.41 -5.74 -0.33 2.57e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs57221529 0.709 rs72703090 chr5:598314 C/T cg25482853 chr8:67687455 SGK3 1.04 10.08 0.53 1.87e-20 Lung disease severity in cystic fibrosis; CESC trans rs7246760 0.867 rs1820114 chr19:9805692 G/A cg02900749 chr2:68251473 NA -0.82 -7.26 -0.41 4.38e-12 Pursuit maintenance gain; CESC cis rs1983170 1.000 rs1983170 chr1:91986482 G/A cg25838465 chr1:92012736 NA 0.45 5.44 0.32 1.22e-7 Eosinophil percentage of white cells; CESC cis rs898097 0.841 rs8074284 chr17:80909967 G/A cg15664640 chr17:80829946 TBCD 0.58 8.22 0.45 9.37e-15 Breast cancer; CESC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.91 -13.45 -0.64 8.56e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12136530 0.744 rs877012 chr1:19772660 G/A cg01832549 chr1:19774989 CAPZB -0.48 -6.85 -0.39 5.28e-11 Lead levels in blood; CESC cis rs2835872 0.758 rs1787398 chr21:39037504 A/C cg06728970 chr21:39037746 KCNJ6 0.3 5.53 0.32 7.57e-8 Electroencephalographic traits in alcoholism; CESC cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg25204440 chr1:209979598 IRF6 0.59 5.92 0.34 9.82e-9 Cleft lip with or without cleft palate; CESC cis rs10089 0.953 rs72794400 chr5:127516028 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.11 0.53 1.58e-20 Ileal carcinoids; CESC cis rs2073300 1.000 rs6137980 chr20:23466726 G/T cg12062639 chr20:23401060 NAPB 0.93 5.89 0.34 1.15e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg04944784 chr2:26401820 FAM59B -0.65 -7.53 -0.42 7.97e-13 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs28491638 chr3:40496263 T/C cg24209194 chr3:40518798 ZNF619 0.5 6.11 0.35 3.59e-9 Renal cell carcinoma; CESC cis rs939574 1.000 rs79013471 chr2:220096122 C/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.84 7.61 0.42 4.85e-13 Platelet distribution width; CESC cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg24818145 chr4:99064322 C4orf37 0.39 5.08 0.3 7.03e-7 Colonoscopy-negative controls vs population controls; CESC trans rs1814175 0.817 rs1794162 chr11:49899506 A/C cg03929089 chr4:120376271 NA -0.93 -16.26 -0.71 1.03e-41 Height; CESC cis rs9457247 0.935 rs1187530 chr6:167376812 C/T cg25258033 chr6:167368657 RNASET2 -0.42 -6.25 -0.36 1.63e-9 Crohn's disease; CESC cis rs2506889 0.553 rs17035189 chr1:10597024 A/G cg20482658 chr1:10539492 PEX14 -0.26 -5.25 -0.31 3.07e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01044692 chr2:208490024 FAM119A 0.65 7.54 0.42 7.63e-13 Gut microbiome composition (summer); CESC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg13770153 chr20:60521292 NA -0.44 -5.7 -0.33 3.2e-8 Body mass index; CESC cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg18301423 chr5:131593218 PDLIM4 0.39 5.5 0.32 9.06e-8 Breast cancer; CESC cis rs1348850 0.914 rs2121430 chr2:178318375 A/G cg22681709 chr2:178499509 PDE11A -0.37 -5.41 -0.32 1.43e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11792861 0.926 rs72607166 chr9:111821530 A/C cg13535736 chr9:111863775 C9orf5 -0.51 -6.81 -0.39 6.45e-11 Menarche (age at onset); CESC cis rs1801251 1.000 rs7606090 chr2:233606740 T/C cg08000102 chr2:233561755 GIGYF2 0.64 9.09 0.49 2.47e-17 Coronary artery disease; CESC cis rs2228479 0.867 rs12919804 chr16:89945369 G/A cg00800038 chr16:89945340 TCF25 -0.88 -7.85 -0.43 1.01e-13 Skin colour saturation; CESC cis rs7520050 0.778 rs2088102 chr1:46032974 T/C cg03146154 chr1:46216737 IPP -0.51 -6.54 -0.37 3.24e-10 Red blood cell count;Reticulocyte count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15213689 chr11:47202094 PACSIN3 0.49 6.31 0.36 1.18e-9 Fibrinogen levels; CESC cis rs3806843 0.864 rs2531343 chr5:140129346 A/G cg26395211 chr5:140044315 WDR55 0.39 5.09 0.3 6.79e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9473147 0.516 rs7767350 chr6:47485126 C/T cg20196966 chr6:47445060 CD2AP 0.41 5.33 0.31 2.13e-7 Platelet distribution width;Mean platelet volume; CESC cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 1.000 rs3096299 chr16:89448663 G/A cg00750074 chr16:89608354 SPG7 -0.36 -5.09 -0.3 6.83e-7 Multiple myeloma (IgH translocation); CESC trans rs274437 0.739 rs10457998 chr6:104790542 C/A cg24439334 chr1:2345374 PEX10 0.55 6.0 0.35 6.49e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3736485 0.816 rs11070851 chr15:51763249 C/G cg08986416 chr15:51914746 DMXL2 0.41 5.21 0.31 3.72e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6545883 0.929 rs2121660 chr2:61653058 T/C cg15711740 chr2:61764176 XPO1 0.4 5.13 0.3 5.47e-7 Tuberculosis; CESC cis rs4888262 0.526 rs7205992 chr16:74590578 T/A cg01733217 chr16:74700730 RFWD3 0.81 11.35 0.57 1.39e-24 Testicular germ cell tumor; CESC cis rs2180341 0.814 rs6569488 chr6:127726256 C/T cg27446573 chr6:127587934 RNF146 0.83 12.03 0.59 6.99e-27 Breast cancer; CESC cis rs763121 0.853 rs2072798 chr22:39148483 G/A cg21395723 chr22:39101663 GTPBP1 0.46 5.97 0.34 7.51e-9 Menopause (age at onset); CESC cis rs2361718 0.564 rs2304844 chr17:78084507 G/C cg27427491 chr17:78079615 GAA -0.41 -6.07 -0.35 4.53e-9 Yeast infection; CESC cis rs6598955 0.724 rs12132137 chr1:26631243 C/T cg04990556 chr1:26633338 UBXN11 -0.75 -10.39 -0.54 2.01e-21 Obesity-related traits; CESC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.2 -0.36 2.21e-9 Parkinson's disease; CESC cis rs17539620 0.519 rs12665532 chr6:154835182 C/G cg20019720 chr6:154832845 CNKSR3 0.43 6.37 0.36 8.33e-10 Lipoprotein (a) levels; CESC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.59 -5.99 -0.35 6.64e-9 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11258043 chr6:73972820 KHDC1 -0.5 -6.09 -0.35 3.87e-9 Ulcerative colitis; CESC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg08470875 chr2:26401718 FAM59B -0.62 -6.71 -0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg21280719 chr6:42927975 GNMT -0.3 -7.02 -0.4 1.85e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs80130819 0.591 rs17122651 chr12:48496660 C/T cg24011408 chr12:48396354 COL2A1 -0.41 -5.18 -0.3 4.47e-7 Prostate cancer; CESC cis rs6430585 0.528 rs7606267 chr2:136668123 T/C cg07169764 chr2:136633963 MCM6 1.28 19.05 0.76 1.45e-51 Corneal structure; CESC cis rs9611565 0.802 rs132916 chr22:41806768 C/G cg06481639 chr22:41940642 POLR3H 0.48 5.55 0.32 7.02e-8 Vitiligo; CESC cis rs36051895 0.575 rs7035251 chr9:5133665 T/A cg02405213 chr9:5042618 JAK2 -0.47 -5.99 -0.35 6.78e-9 Pediatric autoimmune diseases; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11296937 chr11:64084966 PRDX5;TRMT112 0.44 6.23 0.36 1.82e-9 Gut microbiota (bacterial taxa); CESC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs6598955 0.671 rs12141563 chr1:26589636 A/G cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC cis rs2380220 0.541 rs72928273 chr6:96079360 C/T cg15832292 chr6:96025679 MANEA -0.77 -8.1 -0.45 2.07e-14 Behavioural disinhibition (generation interaction); CESC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.71 0.51 2.97e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9896933 0.832 rs79103992 chr17:80855483 G/A cg19500275 chr17:80737654 TBCD 0.66 6.11 0.35 3.63e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs3741151 0.686 rs11544310 chr11:73107592 A/G cg17517138 chr11:73019481 ARHGEF17 0.82 6.54 0.37 3.07e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg07507251 chr3:52567010 NT5DC2 0.47 8.71 0.47 3.42e-16 Electroencephalogram traits; CESC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg17376030 chr22:41985996 PMM1 0.73 7.55 0.42 7.23e-13 Vitiligo; CESC cis rs796364 0.760 rs56285751 chr2:200919836 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs1728785 1.000 rs1170433 chr16:68606081 A/G cg02972257 chr16:68554789 NA -0.59 -6.71 -0.38 1.2e-10 Ulcerative colitis; CESC cis rs6439153 0.933 rs11711812 chr3:128708554 G/A cg24203234 chr3:128598194 ACAD9 0.43 5.59 0.32 5.56e-8 Pneumococcal bacteremia; CESC cis rs6540556 0.517 rs61820570 chr1:209884953 C/T cg05527609 chr1:210001259 C1orf107 -0.73 -7.15 -0.4 8.66e-12 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23375783 chr17:73008576 ICT1 0.53 6.38 0.36 7.66e-10 Gut microbiome composition (summer); CESC cis rs11098499 0.722 rs1814814 chr4:120258124 C/G cg09307838 chr4:120376055 NA 0.81 11.35 0.57 1.39e-24 Corneal astigmatism; CESC cis rs9303401 0.614 rs66480139 chr17:57101538 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.9 11.27 0.57 2.59e-24 Cognitive test performance; CESC cis rs7219021 1.000 rs11868085 chr17:46847575 C/T cg16584676 chr17:46985605 UBE2Z -0.64 -7.23 -0.41 5.13e-12 Schizophrenia or bipolar disorder; CESC cis rs13266463 0.898 rs13267784 chr8:143394915 C/T cg16886403 chr8:143471632 TSNARE1 0.46 5.55 0.32 7.03e-8 Schizophrenia; CESC cis rs9457247 0.935 rs1044059 chr6:167369897 C/A cg25258033 chr6:167368657 RNASET2 -0.41 -6.2 -0.36 2.1e-9 Crohn's disease; CESC cis rs7639513 0.590 rs3729931 chr3:12626516 A/G cg23032965 chr3:12705835 RAF1 -0.62 -8.72 -0.47 3.13e-16 Itch intensity from mosquito bite; CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg07332563 chr6:291687 DUSP22 -0.66 -8.42 -0.46 2.47e-15 Menopause (age at onset); CESC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg18876405 chr7:65276391 NA -0.5 -6.6 -0.38 2.29e-10 Aortic root size; CESC cis rs2011503 1.000 rs2965179 chr19:19512755 G/A cg11584989 chr19:19387371 SF4 0.63 7.42 0.41 1.63e-12 Bipolar disorder; CESC cis rs2933343 0.729 rs1683780 chr3:128640239 C/T cg24203234 chr3:128598194 ACAD9 0.44 5.79 0.33 2.01e-8 IgG glycosylation; CESC cis rs965469 1.000 rs2236092 chr20:3258188 G/C cg25506879 chr20:3388711 C20orf194 -0.57 -6.14 -0.35 2.97e-9 IFN-related cytopenia; CESC cis rs7872515 0.887 rs28727560 chr9:94864754 A/C cg01248375 chr9:94877805 SPTLC1 0.55 5.83 0.34 1.64e-8 Bipolar disorder and schizophrenia; CESC cis rs9635726 0.638 rs2952155 chr17:37861718 T/C cg00129232 chr17:37814104 STARD3 -0.75 -8.46 -0.46 1.82e-15 Primary biliary cholangitis; CESC cis rs6545883 0.929 rs1186711 chr2:61688505 T/C cg15711740 chr2:61764176 XPO1 -0.4 -5.06 -0.3 7.95e-7 Tuberculosis; CESC cis rs3857067 1.000 rs1585652 chr4:95014313 A/G cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.04e-14 QT interval; CESC cis rs10949834 0.878 rs2269083 chr7:73519661 G/A cg07137043 chr7:73588983 EIF4H -0.66 -5.7 -0.33 3.2e-8 Verbal memory performance (residualized delayed recall change); CESC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg23758822 chr17:41437982 NA 1.02 12.83 0.62 1.27e-29 Menopause (age at onset); CESC cis rs7845219 0.544 rs4735330 chr8:95917770 A/C cg23172400 chr8:95962367 TP53INP1 -0.37 -6.78 -0.38 7.89e-11 Type 2 diabetes; CESC trans rs9951602 0.512 rs7241419 chr18:76640778 C/G cg02800362 chr5:177631904 HNRNPAB 0.62 8.1 0.45 1.96e-14 Obesity-related traits; CESC cis rs6570726 0.935 rs371744 chr6:145841024 C/T cg23711669 chr6:146136114 FBXO30 0.77 11.63 0.58 1.61e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.791 rs2081622 chr4:98927369 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7100689 0.577 rs10788545 chr10:82034675 A/G cg09936400 chr10:82049201 MAT1A 0.4 5.85 0.34 1.43e-8 Post bronchodilator FEV1; CESC cis rs7116495 0.609 rs73543643 chr11:71835596 C/T cg10381502 chr11:71823885 C11orf51 1.06 6.77 0.38 8.27e-11 Severe influenza A (H1N1) infection; CESC cis rs3096299 0.967 rs28689480 chr16:89460093 T/C cg08822215 chr16:89438651 ANKRD11 -0.39 -5.84 -0.34 1.51e-8 Multiple myeloma (IgH translocation); CESC trans rs561341 0.941 rs2428336 chr17:30290577 T/C cg27661571 chr11:113659931 NA -0.71 -7.11 -0.4 1.1e-11 Hip circumference adjusted for BMI; CESC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg16545954 chr1:2118288 C1orf86 -0.31 -5.7 -0.33 3.13e-8 Height; CESC cis rs743757 1.000 rs2236971 chr3:50473349 G/A cg10928302 chr3:50126174 RBM5 0.53 5.08 0.3 7.24e-7 Diastolic blood pressure; CESC cis rs7680126 0.596 rs11731652 chr4:10292984 T/C cg11266682 chr4:10021025 SLC2A9 -0.43 -5.72 -0.33 2.9e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs3760982 0.585 rs10422108 chr19:44294868 C/T cg11993925 chr19:44307056 LYPD5 0.33 5.61 0.33 5.11e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18170098 chr16:71880032 ATXN1L -0.46 -6.37 -0.36 8.48e-10 Asthma; CESC cis rs898097 0.841 rs8074284 chr17:80909967 G/A cg15369054 chr17:80825471 TBCD -0.46 -6.2 -0.36 2.13e-9 Breast cancer; CESC cis rs11098499 0.826 rs12511640 chr4:120251248 T/C cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC cis rs9287719 0.967 rs6744854 chr2:10747246 C/G cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC trans rs7246657 0.943 rs7252346 chr19:37914682 G/A cg24637308 chr11:6592297 DNHD1 0.54 6.34 0.36 1.01e-9 Coronary artery calcification; CESC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg15145296 chr3:125709740 NA -0.53 -5.65 -0.33 4.05e-8 Blood pressure (smoking interaction); CESC trans rs4843747 0.803 rs72818522 chr16:88059144 C/T cg26811252 chr16:29126840 RRN3P2 0.71 9.8 0.52 1.51e-19 Menopause (age at onset); CESC cis rs2380220 0.574 rs9400526 chr6:95998441 T/C cg23517279 chr6:96025343 MANEA 0.54 5.8 0.34 1.85e-8 Behavioural disinhibition (generation interaction); CESC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.54 8.08 0.44 2.26e-14 Bipolar disorder; CESC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg16545954 chr1:2118288 C1orf86 -0.31 -5.67 -0.33 3.74e-8 Height; CESC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.22 -0.57 3.68e-24 Glomerular filtration rate (creatinine); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg24086158 chr2:47169120 MCFD2;TTC7A -0.42 -6.05 -0.35 4.89e-9 Vertical cup-disc ratio; CESC cis rs1018836 0.632 rs1028255 chr8:91485578 A/T cg16814680 chr8:91681699 NA -0.62 -8.57 -0.47 8.89e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs6500395 0.962 rs9924483 chr16:48646258 C/T cg04672837 chr16:48644449 N4BP1 0.47 5.57 0.32 6.4e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6570726 0.935 rs1883406 chr6:145823205 A/G cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg21747405 chr11:67723411 NA -0.44 -6.69 -0.38 1.3100000000000001e-10 Blood pressure (smoking interaction); CESC cis rs1975974 0.872 rs17052344 chr17:21717543 A/G cg18423549 chr17:21743878 NA 0.49 6.92 0.39 3.43e-11 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19210712 chr3:44903163 MIR564;TMEM42 0.58 6.58 0.37 2.51e-10 Gut microbiome composition (summer); CESC cis rs7089973 0.966 rs55711292 chr10:116604870 T/G cg23260525 chr10:116636907 FAM160B1 0.38 6.12 0.35 3.43e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17267720 chr15:34396248 PGBD4 -0.43 -6.27 -0.36 1.42e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs72945132 0.882 rs56368270 chr11:70162590 A/G cg14191688 chr11:70257035 CTTN 0.45 5.52 0.32 7.96e-8 Coronary artery disease; CESC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg06138931 chr13:21896616 NA 0.54 5.62 0.33 4.82e-8 White matter hyperintensity burden; CESC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg11644478 chr21:40555479 PSMG1 -0.82 -12.24 -0.6 1.34e-27 Cognitive function; CESC cis rs11122272 0.735 rs2739506 chr1:231529183 T/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs6433857 0.594 rs11894486 chr2:181520678 C/T cg23363182 chr2:181467187 NA -0.46 -6.35 -0.36 9.29e-10 Body mass index; CESC cis rs9457247 1.000 rs364283 chr6:167383750 C/T cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.76e-8 Crohn's disease; CESC cis rs17376456 0.825 rs10476590 chr5:93244884 A/T cg21475434 chr5:93447410 FAM172A 0.76 6.2 0.36 2.16e-9 Diabetic retinopathy; CESC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg22823121 chr1:150693482 HORMAD1 0.4 5.7 0.33 3.2e-8 Melanoma; CESC cis rs11078597 0.708 rs7503952 chr17:1649259 G/C cg18436246 chr17:1640651 WDR81 0.62 7.63 0.42 4.25e-13 Serum albumin level; CESC cis rs643506 0.874 rs609007 chr11:111719593 A/G cg09085632 chr11:111637200 PPP2R1B -0.4 -5.11 -0.3 6.05e-7 Breast cancer; CESC trans rs1814175 0.645 rs4411280 chr11:49962750 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.24 -0.36 1.75e-9 Height; CESC cis rs10876993 0.890 rs810204 chr12:58075733 T/C cg18357645 chr12:58087776 OS9 0.65 10.63 0.55 3.37e-22 Celiac disease or Rheumatoid arthritis; CESC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg22800045 chr5:56110881 MAP3K1 0.83 8.07 0.44 2.47e-14 Type 2 diabetes; CESC cis rs56046484 0.956 rs12904410 chr15:85609788 C/T cg08123816 chr15:85640762 PDE8A -0.46 -5.83 -0.34 1.62e-8 Testicular germ cell tumor; CESC cis rs62432291 0.681 rs397476 chr6:159639284 A/G cg14500486 chr6:159655392 FNDC1 -0.52 -5.91 -0.34 1.07e-8 Joint mobility (Beighton score); CESC cis rs858239 0.601 rs6962526 chr7:23158233 G/A cg23682824 chr7:23144976 KLHL7 0.54 7.4 0.41 1.79e-12 Cerebrospinal fluid biomarker levels; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02477126 chr22:24988729 C22orf36;GGT1 -0.47 -6.02 -0.35 5.79e-9 Asthma; CESC cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg19717773 chr7:2847554 GNA12 -0.54 -8.47 -0.46 1.68e-15 Height; CESC cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg27286337 chr10:134555280 INPP5A 0.68 8.68 0.47 4.08e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs11997175 0.625 rs4268088 chr8:33599343 A/T ch.8.33884649F chr8:33765107 NA 0.51 6.29 0.36 1.34e-9 Body mass index; CESC cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.91e-28 Colonoscopy-negative controls vs population controls; CESC cis rs3105593 0.933 rs3131576 chr15:50863658 T/C cg08437265 chr15:50716283 USP8 0.42 5.49 0.32 9.2e-8 QT interval; CESC cis rs2820292 0.804 rs2644120 chr1:201882277 C/G cg11586189 chr1:201857591 SHISA4 0.38 6.46 0.37 5.09e-10 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg18876405 chr7:65276391 NA 0.51 6.83 0.39 5.69e-11 Aortic root size; CESC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.79e-7 Gut microbiome composition (summer); CESC cis rs796364 0.951 rs6722092 chr2:201059371 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.6 6.17 0.35 2.5e-9 Schizophrenia; CESC cis rs1728785 1.000 rs1645976 chr16:68563509 T/C cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg05313129 chr8:58192883 C8orf71 -0.58 -6.61 -0.38 2.12e-10 Developmental language disorder (linguistic errors); CESC cis rs3096299 0.606 rs4785573 chr16:89565403 A/G cg02187348 chr16:89574699 SPG7 0.5 6.16 0.35 2.71e-9 Multiple myeloma (IgH translocation); CESC cis rs3820928 0.810 rs10175929 chr2:227858609 T/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.53 -0.32 7.7e-8 Pulmonary function; CESC cis rs10256972 0.527 rs2949170 chr7:1216438 A/G cg15112475 chr7:1198522 ZFAND2A -0.42 -6.44 -0.37 5.66e-10 Longevity;Endometriosis; CESC cis rs3091242 0.933 rs11249251 chr1:25770188 C/G cg27572855 chr1:25598939 RHD 0.43 7.22 0.41 5.47e-12 Erythrocyte sedimentation rate; CESC trans rs10506458 0.915 rs60094497 chr12:63394838 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.34 -18.45 -0.75 1.83e-49 Hemostatic factors and hematological phenotypes; CESC cis rs4132509 0.948 rs1458023 chr1:243886673 A/G cg21452805 chr1:244014465 NA 0.51 6.52 0.37 3.45e-10 RR interval (heart rate); CESC cis rs1707322 0.721 rs28501477 chr1:46199084 A/G cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11039798 0.688 rs8188953 chr11:48749201 A/T cg15704280 chr7:45808275 SEPT13 0.7 6.31 0.36 1.14e-9 Axial length; CESC cis rs5753618 0.504 rs5753669 chr22:31905819 T/G cg00478049 chr22:31556069 RNF185 -0.46 -5.52 -0.32 8.25e-8 Colorectal cancer; CESC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg25985355 chr7:65971099 NA 0.32 5.24 0.31 3.24e-7 Aortic root size; CESC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.04 16.56 0.71 9.03e-43 Height; CESC cis rs926938 0.765 rs12407408 chr1:115234275 A/G cg12756093 chr1:115239321 AMPD1 0.65 10.11 0.53 1.58e-20 Autism; CESC cis rs11122272 0.735 rs2808580 chr1:231509259 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs2249625 0.545 rs55681410 chr6:72877859 G/A cg18830697 chr6:72922368 RIMS1 0.42 5.94 0.34 8.7e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg21238619 chr17:78079768 GAA 0.34 5.58 0.32 6.02e-8 Yeast infection; CESC cis rs9430161 0.579 rs7542354 chr1:11040385 G/A cg02454025 chr1:11042201 C1orf127 0.87 13.72 0.64 9.82e-33 Ewing sarcoma; CESC cis rs868036 1.000 rs9972436 chr15:68098027 G/C cg08079166 chr15:68083412 MAP2K5 0.44 6.94 0.39 2.94e-11 Restless legs syndrome; CESC cis rs10823500 0.777 rs2184335 chr10:72006891 C/T cg04118878 chr10:71993077 PPA1 0.5 5.72 0.33 2.81e-8 Blood protein levels; CESC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.81 0.39 6.64e-11 Bipolar disorder; CESC cis rs12348691 0.503 rs1867279 chr9:100616041 T/C cg13688889 chr9:100608707 NA -0.9 -13.65 -0.64 1.78e-32 Alopecia areata; CESC cis rs6121246 0.529 rs73235789 chr20:30196148 T/C cg13852791 chr20:30311386 BCL2L1 0.67 6.71 0.38 1.2e-10 Mean corpuscular hemoglobin; CESC cis rs3026101 0.671 rs3026125 chr17:5293627 T/G cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg19717773 chr7:2847554 GNA12 -0.56 -8.15 -0.45 1.46e-14 Height; CESC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.49 -6.06 -0.35 4.66e-9 Tonsillectomy; CESC cis rs1348850 0.561 rs4893956 chr2:178373452 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.68 6.17 0.35 2.52e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4523957 0.651 rs9910413 chr17:2081419 G/A cg16513277 chr17:2031491 SMG6 -0.71 -10.17 -0.53 1.04e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02565297 chr12:133144810 FBRSL1 -0.53 -6.31 -0.36 1.16e-9 Gut microbiome composition (summer); CESC cis rs9291683 0.632 rs12508991 chr4:10041104 C/T cg02734326 chr4:10020555 SLC2A9 0.47 6.53 0.37 3.29e-10 Bone mineral density; CESC cis rs34638657 0.872 rs2967355 chr16:82200103 G/T cg09439754 chr16:82129088 HSD17B2 0.37 5.33 0.31 2.06e-7 Lung adenocarcinoma; CESC cis rs8014204 0.836 rs11159099 chr14:75235397 A/G cg11812906 chr14:75593930 NEK9 0.42 5.22 0.31 3.66e-7 Caffeine consumption; CESC cis rs10789491 1.000 rs4097354 chr1:47187073 T/G cg03812309 chr1:46938281 NA 0.35 5.04 0.3 8.59e-7 Response to hepatitis C treatment; CESC cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg16262614 chr3:133464971 TF 0.28 5.28 0.31 2.63e-7 Iron status biomarkers; CESC cis rs734999 0.545 rs6666788 chr1:2567500 A/G cg18854424 chr1:2615690 NA -0.3 -5.95 -0.34 8.47e-9 Ulcerative colitis; CESC cis rs60594510 1 rs60594510 chr12:110594503 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.59 0.32 5.76e-8 Intelligence (multi-trait analysis); CESC cis rs3008870 1.000 rs2985797 chr1:67431499 C/T cg02640540 chr1:67518911 SLC35D1 -0.53 -5.59 -0.32 5.68e-8 Lymphocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18313106 chr1:229694614 ABCB10 0.52 6.31 0.36 1.14e-9 Gut microbiome composition (summer); CESC cis rs9790314 0.846 rs899275 chr3:161042104 T/C cg03342759 chr3:160939853 NMD3 -0.54 -7.78 -0.43 1.65e-13 Morning vs. evening chronotype; CESC cis rs7662987 0.517 rs3018047 chr4:100014510 C/T cg13256891 chr4:100009986 ADH5 -0.67 -7.48 -0.42 1.1e-12 Smoking initiation; CESC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg18876405 chr7:65276391 NA 0.58 7.78 0.43 1.59e-13 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22586474 chr7:931148 C7orf20 -0.6 -6.85 -0.39 5.29e-11 Gut microbiome composition (summer); CESC cis rs2576037 0.796 rs2571030 chr18:44573854 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.59 -8.49 -0.46 1.47e-15 Personality dimensions; CESC trans rs208520 0.837 rs208486 chr6:66926255 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -9.88 -0.52 8.61e-20 Exhaled nitric oxide output; CESC cis rs262150 0.501 rs2730206 chr7:158815173 G/C cg19418458 chr7:158789849 NA -0.41 -6.22 -0.36 1.95e-9 Facial morphology (factor 20); CESC cis rs12912251 1.000 rs12916379 chr15:38991520 A/G cg01338139 chr15:38987640 C15orf53 -0.53 -6.16 -0.35 2.63e-9 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs4660306 1.000 rs2356559 chr1:45981512 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.55 -6.97 -0.39 2.45e-11 Homocysteine levels; CESC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg11843238 chr5:131593191 PDLIM4 0.36 5.25 0.31 3.12e-7 Breast cancer; CESC cis rs9640161 0.789 rs34495356 chr7:150057791 A/G cg17279839 chr7:150038598 RARRES2 0.46 5.43 0.32 1.28e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs10504073 0.584 rs1511365 chr8:49975321 A/T cg00325661 chr8:49890786 NA 0.61 9.21 0.49 1.03e-17 Blood metabolite ratios; CESC cis rs7091068 0.566 rs1326220 chr10:95486155 G/A cg20715218 chr10:95462985 C10orf4 0.56 5.38 0.31 1.65e-7 Urinary tract infection frequency; CESC cis rs7267979 0.934 rs2257464 chr20:25265872 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs7923452 0.938 rs34560372 chr10:30773831 G/A cg18806716 chr10:30721971 MAP3K8 0.48 5.67 0.33 3.81e-8 Itch intensity from mosquito bite; CESC cis rs6088580 0.505 rs6141503 chr20:33274469 G/A cg06115741 chr20:33292138 TP53INP2 -0.43 -5.08 -0.3 7.14e-7 Glomerular filtration rate (creatinine); CESC cis rs6570726 0.791 rs621382 chr6:145799144 T/C cg23711669 chr6:146136114 FBXO30 1.0 15.7 0.69 1.01e-39 Lobe attachment (rater-scored or self-reported); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05537210 chr4:110650914 PLA2G12A 0.49 6.99 0.39 2.2e-11 Gut microbiota (bacterial taxa); CESC cis rs7818688 0.614 rs59265059 chr8:95832816 G/A cg16049864 chr8:95962084 TP53INP1 0.55 5.62 0.33 4.81e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs11122272 0.603 rs2998427 chr1:231528112 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.69 -0.43 2.92e-13 Hemoglobin concentration; CESC cis rs3105593 1.000 rs2414060 chr15:50873262 A/G cg08437265 chr15:50716283 USP8 0.4 5.26 0.31 2.92e-7 QT interval; CESC cis rs9300255 0.664 rs28636834 chr12:123871070 A/C cg19016782 chr12:123741754 C12orf65 0.47 6.39 0.37 7.59e-10 Neutrophil percentage of white cells; CESC cis rs2836974 0.931 rs2989330 chr21:40716209 A/G cg11644478 chr21:40555479 PSMG1 0.89 11.51 0.58 3.98e-25 Cognitive function; CESC cis rs1580019 0.961 rs1868776 chr7:32494435 G/T cg06627557 chr7:32535165 LSM5;AVL9 -0.72 -10.09 -0.53 1.86e-20 Cognitive ability; CESC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05809890 chr11:1491432 HCCA2 -0.57 -6.63 -0.38 1.89e-10 Gut microbiome composition (summer); CESC cis rs4481887 0.962 rs10749653 chr1:248481384 C/G cg00666640 chr1:248458726 OR2T12 0.41 6.56 0.37 2.84e-10 Common traits (Other); CESC cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg00033643 chr7:134001901 SLC35B4 0.41 5.28 0.31 2.7e-7 Mean platelet volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11028091 chr15:72522207 PKM2 0.44 6.08 0.35 4.19e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7819412 0.645 rs10156356 chr8:11046209 T/C cg21775007 chr8:11205619 TDH -0.4 -5.28 -0.31 2.7e-7 Triglycerides; CESC cis rs3812762 0.826 rs2292045 chr11:8806709 G/T cg03980550 chr11:8754370 ST5 -0.38 -5.21 -0.3 3.88e-7 Hypospadias; CESC cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg06212747 chr3:49208901 KLHDC8B 0.65 8.37 0.46 3.37e-15 Parkinson's disease; CESC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg21724239 chr8:58056113 NA 0.57 5.09 0.3 6.73e-7 Developmental language disorder (linguistic errors); CESC cis rs1153858 1.000 rs12593230 chr15:45646968 A/T cg21132104 chr15:45694354 SPATA5L1 0.84 11.4 0.57 9.5e-25 Homoarginine levels; CESC cis rs79839061 0.732 rs73207773 chr4:827249 G/A cg07828340 chr4:882639 GAK 0.93 6.39 0.37 7.58e-10 Intelligence (multi-trait analysis); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg05897255 chr7:149535402 ZNF862 0.47 6.38 0.36 7.8e-10 Bronchopulmonary dysplasia; CESC cis rs4764487 0.687 rs10744702 chr12:6349127 G/A cg08284733 chr12:6341482 CD9 0.43 6.34 0.36 1.01e-9 Mean platelet volume; CESC cis rs1950626 0.750 rs35820579 chr14:101435515 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.82 10.42 0.54 1.59e-21 Pelvic organ prolapse (moderate/severe); CESC cis rs13096760 1 rs13096760 chr3:49476806 T/C cg03060546 chr3:49711283 APEH 0.76 11.69 0.58 9.45e-26 Intelligence (multi-trait analysis); CESC cis rs2933343 0.729 rs1680785 chr3:128644816 C/T cg24203234 chr3:128598194 ACAD9 0.43 5.8 0.34 1.93e-8 IgG glycosylation; CESC cis rs453301 0.653 rs2956244 chr8:8885166 A/G cg06636001 chr8:8085503 FLJ10661 0.45 5.88 0.34 1.23e-8 Joint mobility (Beighton score); CESC cis rs6460942 0.591 rs6942551 chr7:12338356 C/T cg06484146 chr7:12443880 VWDE -0.63 -7.0 -0.39 2.16e-11 Coronary artery disease; CESC cis rs1983891 0.955 rs6917029 chr6:41548540 C/G cg20194872 chr6:41519635 FOXP4 0.54 7.72 0.43 2.38e-13 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14539990 chr9:140728301 EHMT1 -0.53 -6.1 -0.35 3.81e-9 Gut microbiome composition (summer); CESC cis rs9300255 0.544 rs1790100 chr12:123656725 G/T cg19016782 chr12:123741754 C12orf65 -0.43 -6.15 -0.35 2.78e-9 Neutrophil percentage of white cells; CESC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.9 0.39 3.85e-11 Bipolar disorder; CESC cis rs225245 0.791 rs4796103 chr17:34025182 A/G cg05299278 chr17:33885742 SLFN14 0.38 5.51 0.32 8.62e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg12365402 chr11:9010492 NRIP3 -0.44 -7.41 -0.41 1.65e-12 Hemoglobin concentration; CESC cis rs3862030 0.500 rs11191327 chr10:104303883 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.24 0.31 3.28e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs4268898 0.662 rs55661701 chr2:24400769 A/C cg20701182 chr2:24300061 SF3B14 0.72 7.23 0.41 5.21e-12 Asthma; CESC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg22800045 chr5:56110881 MAP3K1 0.81 9.96 0.52 4.58e-20 Initial pursuit acceleration; CESC cis rs1005277 0.540 rs4934907 chr10:38015230 A/C cg25517755 chr10:38738941 LOC399744 -0.4 -5.14 -0.3 5.34e-7 Extrinsic epigenetic age acceleration; CESC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 21.62 0.8 1.91e-60 Prudent dietary pattern; CESC cis rs12136530 0.593 rs881247 chr1:19733320 A/G cg01832549 chr1:19774989 CAPZB -0.44 -6.25 -0.36 1.59e-9 Lead levels in blood; CESC cis rs10911251 0.528 rs2147584 chr1:183074764 T/C ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.05e-34 Colorectal cancer; CESC cis rs7584330 0.780 rs12474519 chr2:238377012 G/A cg14458575 chr2:238380390 NA 0.71 9.92 0.52 6.45e-20 Prostate cancer; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg18402987 chr7:1209562 NA 0.49 6.68 0.38 1.4e-10 Longevity;Endometriosis; CESC cis rs4555082 0.874 rs2816606 chr14:105716034 C/T cg13114125 chr14:105738426 BRF1 -0.8 -9.72 -0.51 2.64e-19 Mean platelet volume;Platelet distribution width; CESC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.38 5.06 0.3 7.85e-7 Menopause (age at onset); CESC cis rs7072216 0.727 rs3750603 chr10:100175536 A/T cg26618903 chr10:100175079 PYROXD2 -0.38 -5.96 -0.34 8.02e-9 Metabolite levels; CESC cis rs10197940 0.686 rs12616688 chr2:152242099 C/G cg06191203 chr2:152266755 RIF1 -0.45 -5.36 -0.31 1.77e-7 Lung cancer; CESC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.54 -0.32 7.38e-8 Huntington's disease progression; CESC cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg17366294 chr4:99064904 C4orf37 0.53 7.06 0.4 1.42e-11 Colonoscopy-negative controls vs population controls; CESC trans rs1945213 0.694 rs11227181 chr11:55856053 C/T cg15704280 chr7:45808275 SEPT13 0.76 7.34 0.41 2.57e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg08736216 chr1:53307985 ZYG11A 0.43 7.13 0.4 9.53e-12 Monocyte count; CESC cis rs2073300 0.609 rs3827085 chr20:23356985 A/T cg16736954 chr20:23401023 NAPB 0.81 6.09 0.35 4.02e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4319547 0.656 rs1553179 chr12:122831073 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -5.81 -0.34 1.78e-8 Body mass index; CESC cis rs6732160 0.691 rs11886257 chr2:73416873 C/T cg01422370 chr2:73384389 NA 0.44 7.54 0.42 7.45e-13 Intelligence (multi-trait analysis); CESC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg11644478 chr21:40555479 PSMG1 1.01 16.18 0.7 2.08e-41 Cognitive function; CESC cis rs2204008 0.630 rs1283300 chr12:38150227 C/T cg26384229 chr12:38710491 ALG10B -0.44 -5.99 -0.35 6.87e-9 Bladder cancer; CESC cis rs644799 0.931 rs496305 chr11:95567035 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.68 8.6 0.47 6.86e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg11764359 chr7:65958608 NA 0.82 9.37 0.5 3.25e-18 Aortic root size; CESC cis rs9929218 0.954 rs7198799 chr16:68818390 C/T cg02972257 chr16:68554789 NA 0.49 5.82 0.34 1.7e-8 Colorectal cancer; CESC cis rs854765 0.654 rs9911281 chr17:17762457 G/C cg09796270 chr17:17721594 SREBF1 -0.4 -5.75 -0.33 2.43e-8 Total body bone mineral density; CESC cis rs208520 0.837 rs208498 chr6:66931560 G/A cg07460842 chr6:66804631 NA -0.82 -10.01 -0.52 3.23e-20 Exhaled nitric oxide output; CESC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg05564831 chr3:52568323 NT5DC2 0.46 6.85 0.39 5.24e-11 Bipolar disorder; CESC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg18876405 chr7:65276391 NA -0.49 -6.75 -0.38 9.38e-11 Aortic root size; CESC cis rs929354 0.772 rs1182432 chr7:157029176 A/G cg05182265 chr7:156933206 UBE3C -0.45 -6.66 -0.38 1.59e-10 Body mass index; CESC cis rs7712401 0.645 rs154497 chr5:122221420 T/C cg19412675 chr5:122181750 SNX24 0.4 5.05 0.3 8.3e-7 Mean platelet volume; CESC cis rs4535700 0.501 rs2135116 chr7:55991144 A/G cg09872392 chr7:56161020 PHKG1 0.41 5.81 0.34 1.8e-8 Macular telangiectasia type 2; CESC cis rs9596863 1.000 rs9596856 chr13:54409401 C/T ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg00745463 chr17:30367425 LRRC37B -0.82 -7.48 -0.42 1.08e-12 Hip circumference adjusted for BMI; CESC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg13628971 chr7:2884303 GNA12 0.63 8.09 0.45 2.17e-14 Height; CESC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg24399712 chr22:39784796 NA -0.84 -11.77 -0.59 5.08e-26 Intelligence (multi-trait analysis); CESC cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg06028808 chr11:68637592 NA 0.44 5.05 0.3 8.33e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg25019033 chr10:957182 NA -0.65 -8.25 -0.45 7.58e-15 Eosinophil percentage of granulocytes; CESC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg14196790 chr5:131705035 SLC22A5 0.33 5.31 0.31 2.3e-7 Breast cancer; CESC cis rs6489785 0.509 rs4767937 chr12:121223244 G/C cg02419362 chr12:121203948 SPPL3 0.35 5.72 0.33 2.87e-8 Longevity;Allergic disease (asthma, hay fever or eczema); CESC cis rs977987 0.806 rs12051136 chr16:75435731 G/T cg03315344 chr16:75512273 CHST6 0.41 5.85 0.34 1.43e-8 Dupuytren's disease; CESC cis rs748404 0.578 rs510108 chr15:43605439 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.54 8.57 0.47 8.63e-16 Lung cancer; CESC trans rs1814175 0.935 rs28586931 chr11:49693872 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -17.88 -0.74 1.87e-47 Height; CESC cis rs4919087 0.892 rs2065861 chr10:99004608 C/T cg25902810 chr10:99078978 FRAT1 0.65 9.33 0.5 4.53e-18 Monocyte count; CESC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg26335602 chr6:28129616 ZNF389 0.41 5.54 0.32 7.32e-8 Parkinson's disease; CESC cis rs1728785 1.000 rs4783657 chr16:68586322 G/T cg02972257 chr16:68554789 NA -0.56 -6.35 -0.36 9.09e-10 Ulcerative colitis; CESC cis rs6076065 0.707 rs12349 chr20:23352480 A/G cg11657817 chr20:23433608 CST11 0.41 6.12 0.35 3.37e-9 Facial morphology (factor 15, philtrum width); CESC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg00166722 chr3:10149974 C3orf24 0.52 6.43 0.37 5.93e-10 Alzheimer's disease; CESC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg18402987 chr7:1209562 NA 0.48 5.19 0.3 4.13e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg18337363 chr3:52569053 NT5DC2 0.3 5.5 0.32 8.74e-8 Electroencephalogram traits; CESC cis rs6977660 0.652 rs12673842 chr7:19747437 T/C cg07541023 chr7:19748670 TWISTNB 0.79 6.77 0.38 8.08e-11 Thyroid stimulating hormone; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00160902 chr4:16944285 NA -0.43 -6.2 -0.36 2.1e-9 Gut microbiota (bacterial taxa); CESC cis rs7605827 0.791 rs7604881 chr2:15476735 T/A cg19274914 chr2:15703543 NA 0.3 5.38 0.31 1.64e-7 Educational attainment (years of education); CESC trans rs2727020 0.755 rs652655 chr11:49251293 G/A cg15704280 chr7:45808275 SEPT13 0.86 14.21 0.66 1.88e-34 Coronary artery disease; CESC cis rs4629180 0.917 rs34217240 chr2:102136682 G/A cg04415270 chr2:102091202 RFX8 0.43 6.72 0.38 1.08e-10 Chronic rhinosinusitis with nasal polyps; CESC cis rs875971 0.577 rs34888281 chr7:65585771 C/T cg18876405 chr7:65276391 NA -0.7 -9.71 -0.51 2.97e-19 Aortic root size; CESC cis rs7605827 0.930 rs2111458 chr2:15598039 T/A cg19274914 chr2:15703543 NA 0.33 5.82 0.34 1.73e-8 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14634842 chr2:232574012 PTMA -0.59 -6.58 -0.37 2.43e-10 Gut microbiome composition (summer); CESC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg06074448 chr4:187884817 NA -0.37 -5.43 -0.32 1.27e-7 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19886179 chr2:162164993 PSMD14 0.55 6.36 0.36 8.58e-10 Gut microbiome composition (summer); CESC cis rs7474896 0.537 rs598857 chr10:38302926 A/G cg00409905 chr10:38381863 ZNF37A 0.46 5.15 0.3 5.05e-7 Obesity (extreme); CESC trans rs9354308 1.000 rs9360161 chr6:66565457 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.53 6.31 0.36 1.16e-9 Metabolite levels; CESC cis rs826838 0.967 rs1719854 chr12:39127707 G/A cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs8020095 0.571 rs8006371 chr14:67375341 T/G cg19548862 chr14:67692701 FAM71D -0.5 -6.1 -0.35 3.83e-9 Depression (quantitative trait); CESC cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03149719 chr17:1358724 CRK -0.57 -6.2 -0.36 2.12e-9 Gut microbiome composition (summer); CESC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg25036284 chr2:26402008 FAM59B -0.74 -8.4 -0.46 2.72e-15 Gut microbiome composition (summer); CESC cis rs7927592 0.731 rs643609 chr11:68241833 A/G cg16797656 chr11:68205561 LRP5 0.5 7.75 0.43 1.98e-13 Total body bone mineral density; CESC cis rs9611565 0.608 rs202652 chr22:41838792 A/G cg06634786 chr22:41940651 POLR3H 0.58 6.31 0.36 1.14e-9 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13823003 chr17:72856049 GRIN2C 0.46 6.1 0.35 3.74e-9 Gut microbiome composition (summer); CESC cis rs4803468 1.000 rs17318666 chr19:41940342 T/G cg09537434 chr19:41945824 ATP5SL 1.13 21.82 0.8 4.09e-61 Height; CESC cis rs8112211 0.834 rs3843754 chr19:38807184 G/A cg14299480 chr19:38876666 GGN -0.42 -5.73 -0.33 2.79e-8 Blood protein levels; CESC cis rs1881797 1.000 rs12061460 chr1:247686787 G/A cg21399703 chr1:247681439 NA 0.55 7.37 0.41 2.13e-12 Acute lymphoblastic leukemia (childhood); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16725865 chr1:92546135 BTBD8 0.44 6.03 0.35 5.46e-9 Gut microbiota (bacterial taxa); CESC cis rs7647973 0.600 rs11920267 chr3:49275964 G/A cg06212747 chr3:49208901 KLHDC8B 0.7 10.38 0.54 2.04e-21 Menarche (age at onset); CESC cis rs72772090 0.539 rs11747179 chr5:96112969 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.04 -0.3 8.7e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20706599 chr15:90777202 CIB1;C15orf58 -0.48 -6.32 -0.36 1.11e-9 Ulcerative colitis; CESC cis rs708547 0.624 rs1277284 chr4:57855361 T/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.6 8.92 0.48 7.94e-17 Response to bleomycin (chromatid breaks); CESC cis rs2243480 1.000 rs778704 chr7:65863467 T/C cg13147721 chr7:65941812 NA -0.95 -8.95 -0.48 6.27e-17 Diabetic kidney disease; CESC cis rs798766 1.000 rs798754 chr4:1720757 A/G cg07041428 chr4:1763019 NA -0.37 -5.44 -0.32 1.19e-7 Bladder cancer;Urinary bladder cancer; CESC cis rs11153306 0.515 rs3213575 chr6:111919271 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.4 -5.78 -0.33 2.13e-8 Tonsillectomy; CESC cis rs3820068 0.705 rs2145397 chr1:15896199 G/A cg18192808 chr1:15853278 DNAJC16 0.45 5.48 0.32 9.95e-8 Systolic blood pressure; CESC cis rs7216064 1.000 rs8081517 chr17:65845697 A/T cg07042672 chr17:66097459 LOC651250 -0.57 -6.64 -0.38 1.72e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9811920 0.569 rs793445 chr3:99576644 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.63 -10.21 -0.53 7.53e-21 Axial length; CESC cis rs12765878 0.967 rs10883940 chr10:105650598 G/A cg24587175 chr10:105670608 OBFC1 0.33 5.43 0.32 1.28e-7 Coronary artery disease; CESC trans rs3942852 0.545 rs10838798 chr11:48091303 T/G cg03929089 chr4:120376271 NA -0.64 -7.91 -0.44 6.85e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs1178968 0.818 rs2528709 chr7:72788457 C/A cg25889504 chr7:72793014 NA 0.44 5.13 0.3 5.52e-7 Triglyceride levels; CESC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg18350739 chr11:68623251 NA -0.46 -6.94 -0.39 3.09e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg02725872 chr8:58115012 NA -0.45 -6.84 -0.39 5.31e-11 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12810189 chr7:107220588 BCAP29 0.56 6.03 0.35 5.62e-9 Gut microbiome composition (summer); CESC cis rs2576037 0.521 rs4986227 chr18:44595031 G/C cg19077165 chr18:44547161 KATNAL2 -0.43 -5.66 -0.33 4.02e-8 Personality dimensions; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03416154 chr22:21336337 LZTR1 -0.45 -6.19 -0.36 2.33e-9 Fibrinogen levels; CESC cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.84 13.61 0.64 2.4e-32 Hip circumference adjusted for BMI; CESC cis rs1538970 0.962 rs2185549 chr1:45814103 C/T cg06784218 chr1:46089804 CCDC17 -0.32 -5.24 -0.31 3.2e-7 Platelet count; CESC cis rs66887589 0.616 rs6822808 chr4:120217365 C/A cg09307838 chr4:120376055 NA 0.66 8.95 0.48 6.29e-17 Diastolic blood pressure; CESC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.97 0.59 1.11e-26 Alzheimer's disease; CESC cis rs72781680 0.898 rs116113042 chr2:23960194 G/T cg08917208 chr2:24149416 ATAD2B 0.96 8.67 0.47 4.28e-16 Lymphocyte counts; CESC cis rs1030268 0.651 rs12707118 chr7:133474900 C/T cg10665199 chr7:133106180 EXOC4 -0.57 -6.22 -0.36 1.88e-9 Intelligence (multi-trait analysis); CESC cis rs4450798 0.500 rs73139918 chr3:13789096 T/G cg23332027 chr3:13681764 NA 0.41 5.72 0.33 2.83e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs262150 0.659 rs2730275 chr7:158793397 A/G cg09640425 chr7:158790006 NA -0.38 -5.79 -0.33 2.02e-8 Facial morphology (factor 20); CESC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg11663144 chr21:46675770 NA -0.62 -9.76 -0.51 2.06e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09664812 chr18:9475361 RALBP1 0.45 6.21 0.36 2.08e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2742234 0.590 rs1254965 chr10:43689853 C/T cg15436174 chr10:43711423 RASGEF1A 0.5 5.84 0.34 1.5e-8 Hirschsprung disease; CESC cis rs35146811 0.807 rs10228764 chr7:99608029 A/G cg22906224 chr7:99728672 NA 0.45 5.37 0.31 1.75e-7 Coronary artery disease; CESC cis rs7474896 0.609 rs11011336 chr10:37985316 A/G cg25427524 chr10:38739819 LOC399744 -0.46 -5.38 -0.31 1.6e-7 Obesity (extreme); CESC cis rs963731 0.649 rs10201980 chr2:39204820 C/T cg04010122 chr2:39346883 SOS1 0.68 5.1 0.3 6.48e-7 Corticobasal degeneration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07889337 chr17:38257022 NR1D1 0.63 7.75 0.43 1.91e-13 Gut microbiome composition (summer); CESC cis rs4654899 1.000 rs7554997 chr1:21400139 C/T cg05370193 chr1:21551575 ECE1 0.4 5.97 0.34 7.48e-9 Superior frontal gyrus grey matter volume; CESC cis rs12295403 0.691 rs9705036 chr11:18686916 A/G cg20219074 chr11:18656078 SPTY2D1 -0.48 -5.25 -0.31 3.2e-7 Ovarian reserve; CESC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg22968622 chr17:43663579 NA 1.3 18.48 0.75 1.45e-49 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg08736216 chr1:53307985 ZYG11A 0.32 5.74 0.33 2.59e-8 Monocyte count; CESC cis rs2243480 1.000 rs316304 chr7:65616894 T/C cg18252515 chr7:66147081 NA -1.42 -14.5 -0.67 1.72e-35 Diabetic kidney disease; CESC cis rs9486719 1.000 rs2472890 chr6:96867646 C/T cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs9488822 0.676 rs12190737 chr6:116328128 C/A cg18764771 chr6:116381957 FRK 0.22 5.39 0.31 1.57e-7 Cholesterol, total;LDL cholesterol; CESC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -6.75 -0.38 9.09e-11 Personality dimensions; CESC cis rs11792861 0.926 rs7855282 chr9:111802614 T/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.47 5.9 0.34 1.11e-8 Menarche (age at onset); CESC cis rs8067354 0.872 rs1295925 chr17:57910263 T/C cg02344993 chr17:57696989 CLTC -0.48 -6.15 -0.35 2.86e-9 Hemoglobin concentration; CESC cis rs2180341 0.694 rs2875972 chr6:127585522 T/C cg27446573 chr6:127587934 RNF146 0.88 12.43 0.61 2.93e-28 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20796294 chr1:220219430 EPRS -0.48 -6.1 -0.35 3.65e-9 Ulcerative colitis; CESC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg09359103 chr1:154839909 KCNN3 -0.66 -12.33 -0.6 6.5e-28 Prostate cancer; CESC trans rs7672847 0.547 rs56076741 chr4:170456047 A/G cg19308436 chr1:237949471 RYR2 0.63 6.82 0.39 6.26e-11 Subjective well-being; CESC cis rs644799 1.000 rs546809 chr11:95579938 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.56 6.72 0.38 1.11e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03592283 chr3:44666723 ZNF197 0.65 7.77 0.43 1.75e-13 Gut microbiome composition (summer); CESC cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg26597838 chr10:835615 NA -1.12 -11.05 -0.56 1.32e-23 Eosinophil percentage of granulocytes; CESC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg00290607 chr11:67383545 NA 0.4 5.81 0.34 1.83e-8 Mean corpuscular volume; CESC cis rs9300255 0.510 rs1790109 chr12:123637752 C/G cg05973401 chr12:123451056 ABCB9 0.5 5.77 0.33 2.18e-8 Neutrophil percentage of white cells; CESC cis rs5747327 0.770 rs5746460 chr22:18178393 A/T cg19898043 chr22:18121309 BCL2L13 -0.4 -5.16 -0.3 4.95e-7 Myeloid white cell count;Granulocyte count; CESC cis rs11711311 1.000 rs1043132 chr3:113528689 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.71 10.25 0.53 5.62e-21 IgG glycosylation; CESC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg07952391 chr2:88470173 THNSL2 -0.54 -8.13 -0.45 1.62e-14 Response to metformin (IC50); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14733031 chr19:17904427 B3GNT3 -0.36 -6.07 -0.35 4.38e-9 Gambling; CESC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg13126279 chr21:47581558 C21orf56 -0.49 -6.62 -0.38 1.96e-10 Testicular germ cell tumor; CESC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.51e-24 Menopause (age at onset); CESC cis rs8018808 0.935 rs2242619 chr14:77895119 C/T cg20045696 chr14:77926864 AHSA1 -0.43 -6.04 -0.35 5.18e-9 Myeloid white cell count; CESC trans rs1814175 0.817 rs6486046 chr11:49997017 T/C cg15704280 chr7:45808275 SEPT13 -1.05 -20.9 -0.79 5.74e-58 Height; CESC cis rs9287719 0.967 rs10195802 chr2:10754532 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs2050392 0.929 rs10826798 chr10:30700904 G/A cg25182066 chr10:30743637 MAP3K8 0.38 5.04 0.3 8.52e-7 Inflammatory bowel disease; CESC cis rs66573146 0.572 rs66819208 chr4:6946128 A/G cg00086871 chr4:6988644 TBC1D14 1.05 6.92 0.39 3.44e-11 Granulocyte percentage of myeloid white cells; CESC cis rs3784262 1.000 rs4646629 chr15:58255215 A/G cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.13 -0.3 5.51e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs2115630 0.905 rs1975277 chr15:85329558 C/T cg09876464 chr15:85330779 ZNF592 0.37 5.8 0.34 1.88e-8 P wave terminal force; CESC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg18876405 chr7:65276391 NA -0.51 -7.07 -0.4 1.34e-11 Aortic root size; CESC cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg03467027 chr4:99064603 C4orf37 0.42 5.3 0.31 2.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8114671 0.836 rs13042358 chr20:33634479 G/A cg06115741 chr20:33292138 TP53INP2 -0.44 -5.29 -0.31 2.53e-7 Height; CESC cis rs1707322 1.000 rs1707337 chr1:46508769 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.65 -0.33 4.08e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg00784671 chr22:46762841 CELSR1 -0.5 -5.37 -0.31 1.73e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7193541 0.646 rs7188880 chr16:74664810 A/T cg05580060 chr16:74700937 RFWD3 -0.48 -6.21 -0.36 1.99e-9 Multiple myeloma; CESC cis rs3749237 0.615 rs11130202 chr3:49566715 C/T cg03060546 chr3:49711283 APEH 0.76 11.64 0.58 1.48e-25 Resting heart rate; CESC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg27170947 chr2:26402098 FAM59B -0.58 -6.84 -0.39 5.56e-11 Gut microbiome composition (summer); CESC cis rs7647973 0.600 rs12631989 chr3:49273996 C/T cg03060546 chr3:49711283 APEH 0.51 6.82 0.39 6.1e-11 Menarche (age at onset); CESC cis rs1506636 0.525 rs7812023 chr7:123260228 C/T cg03229431 chr7:123269106 ASB15 -0.48 -5.79 -0.34 1.96e-8 Plateletcrit;Platelet count; CESC cis rs4629180 0.727 rs10188564 chr2:102101064 C/A cg04415270 chr2:102091202 RFX8 -0.46 -7.52 -0.42 8.59e-13 Chronic rhinosinusitis with nasal polyps; CESC cis rs7210086 0.808 rs4331375 chr17:70640082 A/G cg04206342 chr17:70636940 NA -0.35 -6.36 -0.36 8.76e-10 Ulcerative colitis; CESC cis rs11997175 0.597 rs6988880 chr8:33594504 C/T ch.8.33884649F chr8:33765107 NA 0.51 6.29 0.36 1.34e-9 Body mass index; CESC cis rs7208859 0.573 rs216442 chr17:28931197 T/G cg14008862 chr17:28927542 LRRC37B2 0.73 5.52 0.32 8.23e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg27170947 chr2:26402098 FAM59B 0.68 6.75 0.38 9.19e-11 Gut microbiome composition (summer); CESC cis rs10883723 0.641 rs80146619 chr10:104405850 G/A cg22532475 chr10:104410764 TRIM8 -0.42 -5.65 -0.33 4.18e-8 Allergic disease (asthma, hay fever or eczema); CESC trans rs561341 1.000 rs72825740 chr17:30338356 A/G cg20587970 chr11:113659929 NA -1.5 -18.68 -0.75 2.92e-50 Hip circumference adjusted for BMI; CESC cis rs11190604 1.000 rs11190604 chr10:102302457 A/G cg07080220 chr10:102295463 HIF1AN 0.63 5.73 0.33 2.74e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs3008870 1.000 rs2985811 chr1:67377722 G/T cg02640540 chr1:67518911 SLC35D1 0.49 5.21 0.3 3.81e-7 Lymphocyte percentage of white cells; CESC cis rs992157 0.735 rs2271541 chr2:219082119 G/T cg00012203 chr2:219082015 ARPC2 0.85 12.32 0.6 7.16e-28 Colorectal cancer; CESC cis rs2243480 1.000 rs1964692 chr7:65454183 G/A cg12463550 chr7:65579703 CRCP 0.72 5.81 0.34 1.8e-8 Diabetic kidney disease; CESC trans rs116095464 0.558 rs10059907 chr5:205360 G/C cg00938859 chr5:1591904 SDHAP3 0.66 6.26 0.36 1.55e-9 Breast cancer; CESC cis rs7666738 0.645 rs10013290 chr4:99082799 G/A cg17366294 chr4:99064904 C4orf37 0.55 7.46 0.42 1.21e-12 Colonoscopy-negative controls vs population controls; CESC cis rs9314323 0.862 rs3808580 chr8:26250296 C/T cg13160058 chr8:26243215 BNIP3L 0.31 5.08 0.3 7.01e-7 Red cell distribution width; CESC cis rs4450131 0.500 rs2362515 chr10:126336158 C/T cg20435097 chr10:126320824 FAM53B 0.28 5.03 0.3 8.99e-7 White blood cell count (basophil); CESC cis rs6964587 0.692 rs6970629 chr7:91846599 T/C cg17063962 chr7:91808500 NA 0.46 6.56 0.37 2.8e-10 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07207053 chr12:132601934 EP400NL 0.51 6.58 0.37 2.45e-10 Fibrinogen levels; CESC cis rs2228479 0.717 rs17233678 chr16:89809962 T/C cg04013166 chr16:89971882 TCF25 0.77 6.69 0.38 1.32e-10 Skin colour saturation; CESC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg17376030 chr22:41985996 PMM1 0.72 7.9 0.44 7.33e-14 Vitiligo; CESC cis rs8044868 0.548 rs3909541 chr16:72201119 C/T cg16558253 chr16:72132732 DHX38 0.39 5.86 0.34 1.35e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs12142240 0.698 rs17361936 chr1:46862893 C/T cg10495392 chr1:46806563 NSUN4 0.56 6.14 0.35 2.98e-9 Menopause (age at onset); CESC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg11764359 chr7:65958608 NA 0.89 13.09 0.63 1.58e-30 Aortic root size; CESC cis rs1425132 0.905 rs10234231 chr7:37563810 C/T cg15028436 chr7:37888078 TXNDC3 -0.32 -5.41 -0.32 1.42e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin); CESC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg22535103 chr8:58192502 C8orf71 -0.94 -9.37 -0.5 3.38e-18 Developmental language disorder (linguistic errors); CESC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg14403583 chr14:105418241 AHNAK2 -0.57 -7.9 -0.44 7.61e-14 Rheumatoid arthritis; CESC cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg20701182 chr2:24300061 SF3B14 0.91 10.23 0.53 6.45e-21 Lymphocyte counts; CESC cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg02297831 chr4:17616191 MED28 0.6 7.51 0.42 9.14e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs67311347 1.000 rs12488805 chr3:40422869 C/T cg09455208 chr3:40491958 NA 0.52 8.38 0.46 3.16e-15 Renal cell carcinoma; CESC trans rs7615952 0.673 rs35001498 chr3:125628644 A/G cg07211511 chr3:129823064 LOC729375 -0.88 -8.25 -0.45 7.56e-15 Blood pressure (smoking interaction); CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.37 5.46 0.32 1.08e-7 Electroencephalogram traits; CESC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg17372223 chr3:52568218 NT5DC2 0.41 6.34 0.36 9.92e-10 Electroencephalogram traits; CESC cis rs1904096 0.506 rs2865350 chr4:95212813 A/T cg11021082 chr4:95130006 SMARCAD1 0.64 9.38 0.5 3.19e-18 Type 2 diabetes; CESC cis rs4664293 0.715 rs13002625 chr2:160504625 T/C cg08347373 chr2:160653686 CD302 0.3 5.15 0.3 5.08e-7 Monocyte percentage of white cells; CESC cis rs2204008 0.837 rs11168341 chr12:37961951 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.76 0.38 8.67e-11 Bladder cancer; CESC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.13 -0.3 5.56e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10883266 chr13:100741297 PCCA 0.59 6.92 0.39 3.42e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.27e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg11366901 chr6:160182831 ACAT2 0.71 8.49 0.46 1.47e-15 Age-related macular degeneration (geographic atrophy); CESC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg18402987 chr7:1209562 NA 0.75 7.52 0.42 8.71e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs710216 0.917 rs3754223 chr1:43419091 A/T cg07803811 chr1:43423981 SLC2A1 0.47 5.05 0.3 8.41e-7 Red cell distribution width; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08602689 chr13:103452535 BIVM;KDELC1 0.51 6.9 0.39 3.84e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg18252515 chr7:66147081 NA -0.47 -6.2 -0.36 2.17e-9 Aortic root size; CESC cis rs11997175 0.715 rs7012923 chr8:33630937 A/C ch.8.33884649F chr8:33765107 NA 0.53 6.24 0.36 1.74e-9 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11280390 chr19:8478043 MARCH2 0.54 6.32 0.36 1.1e-9 Gut microbiome composition (summer); CESC cis rs2882667 0.931 rs7706391 chr5:138349164 G/A cg04439458 chr5:138467593 SIL1 -0.33 -5.68 -0.33 3.5e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg18301423 chr5:131593218 PDLIM4 0.39 5.5 0.32 8.95e-8 Breast cancer; CESC cis rs12956009 0.558 rs12960592 chr18:44857203 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 5.73 0.33 2.78e-8 Educational attainment (years of education); CESC cis rs2739330 0.892 rs5751776 chr22:24266954 A/C cg10150615 chr22:24372951 LOC391322 -0.59 -8.05 -0.44 2.79e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10883723 0.773 rs7917402 chr10:104246690 C/T cg22532475 chr10:104410764 TRIM8 -0.33 -5.69 -0.33 3.44e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs72781680 0.752 rs72796110 chr2:23905658 T/A cg08917208 chr2:24149416 ATAD2B 1.16 10.42 0.54 1.59e-21 Lymphocyte counts; CESC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg13206674 chr6:150067644 NUP43 0.44 6.52 0.37 3.54e-10 Lung cancer; CESC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg04025307 chr7:1156635 C7orf50 0.57 9.67 0.51 3.9e-19 Longevity;Endometriosis; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg07193667 chr4:48501509 FRYL 0.44 6.33 0.36 1.05e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg22535103 chr8:58192502 C8orf71 -0.95 -10.54 -0.54 6.39e-22 Developmental language disorder (linguistic errors); CESC cis rs10078 0.848 rs890985 chr5:479746 C/G cg15813090 chr5:442598 EXOC3;C5orf55 0.34 5.08 0.3 7.14e-7 Fat distribution (HIV); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02407659 chr6:105628063 POPDC3 0.41 6.43 0.37 5.83e-10 Gambling; CESC cis rs3820068 0.705 rs4646063 chr1:15829813 G/A cg17385448 chr1:15911702 AGMAT 0.42 6.23 0.36 1.86e-9 Systolic blood pressure; CESC cis rs4268898 0.965 rs13033241 chr2:24476118 G/C cg06627628 chr2:24431161 ITSN2 0.67 8.1 0.45 1.96e-14 Asthma; CESC cis rs6484504 0.532 rs10835757 chr11:31281902 C/T cg14844989 chr11:31128820 NA -0.39 -5.45 -0.32 1.14e-7 Red blood cell count; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24132523 chr1:145827062 GPR89A -0.47 -6.54 -0.37 3.16e-10 Asthma; CESC trans rs2727020 0.634 rs11040331 chr11:49345726 T/C cg15704280 chr7:45808275 SEPT13 -0.78 -8.94 -0.48 6.63e-17 Coronary artery disease; CESC cis rs9905704 0.645 rs831952 chr17:56669583 T/C cg12560992 chr17:57184187 TRIM37 0.64 5.96 0.34 8.03e-9 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09603710 chr16:716055 WDR90 0.45 6.42 0.37 6.21e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21594567 chr8:146228379 ZNF252;C8orf77 0.53 6.1 0.35 3.8e-9 Gut microbiome composition (summer); CESC trans rs561341 0.654 rs6505265 chr17:30172580 C/T cg27661571 chr11:113659931 NA 0.64 6.02 0.35 5.77e-9 Hip circumference adjusted for BMI; CESC cis rs875971 0.658 rs432667 chr7:65514633 A/G cg12463550 chr7:65579703 CRCP 0.59 7.47 0.42 1.16e-12 Aortic root size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05518842 chr16:1823291 MRPS34;EME2 -0.49 -6.18 -0.35 2.42e-9 Ulcerative colitis; CESC cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg17366294 chr4:99064904 C4orf37 0.62 8.86 0.48 1.22e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6728642 1.000 rs59178801 chr2:97604455 C/T cg26665480 chr2:98280029 ACTR1B -0.69 -6.92 -0.39 3.46e-11 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs72781680 0.660 rs72780104 chr2:23983715 A/G cg08917208 chr2:24149416 ATAD2B 0.96 8.7 0.47 3.55e-16 Lymphocyte counts; CESC trans rs1223629 1.000 rs57695785 chr10:95943813 C/T cg16346422 chr11:2920819 SLC22A18;SLC22A18AS 0.67 6.04 0.35 5.08e-9 Glucose homeostasis traits; CESC trans rs9325144 0.560 rs10785586 chr12:38676197 G/A cg23762105 chr12:34175262 ALG10 0.49 6.33 0.36 1.04e-9 Morning vs. evening chronotype; CESC cis rs4790333 1.000 rs4790333 chr17:2262703 A/G cg02569219 chr17:2266849 SGSM2 -0.48 -6.32 -0.36 1.09e-9 Proinsulin levels; CESC cis rs787274 0.543 rs10114623 chr9:115631360 G/A cg13803584 chr9:115635662 SNX30 -0.63 -5.93 -0.34 9.35e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7116495 0.737 rs6592456 chr11:71737663 G/A cg26138937 chr11:71823887 C11orf51 -1.28 -7.54 -0.42 7.59e-13 Severe influenza A (H1N1) infection; CESC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.53 6.37 0.36 8.31e-10 Breast cancer; CESC cis rs921968 0.643 rs612874 chr2:219492924 T/C cg02176678 chr2:219576539 TTLL4 0.39 6.63 0.38 1.84e-10 Mean corpuscular hemoglobin concentration; CESC trans rs9486715 0.838 rs7770889 chr6:96858453 C/T cg16678718 chr17:76497959 DNAH17 -0.44 -6.07 -0.35 4.41e-9 Headache; CESC cis rs962856 0.964 rs6546303 chr2:67613118 G/A cg09028215 chr2:67624308 ETAA1 -0.41 -5.47 -0.32 1.02e-7 Pancreatic cancer; CESC cis rs2262909 0.962 rs12610034 chr19:22314528 G/A cg11619707 chr19:22235551 ZNF257 0.32 5.15 0.3 5.21e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs9911578 1.000 rs6503866 chr17:56619581 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC cis rs7647973 0.588 rs9883000 chr3:49667691 A/G cg03060546 chr3:49711283 APEH 0.7 8.41 0.46 2.49e-15 Menarche (age at onset); CESC cis rs4835473 0.932 rs28377887 chr4:144898228 G/A cg25736465 chr4:144833511 NA 0.39 6.08 0.35 4.07e-9 Immature fraction of reticulocytes; CESC cis rs2070488 0.965 rs3762788 chr3:38493852 C/A cg24069376 chr3:38537580 EXOG 0.48 8.73 0.47 2.97e-16 Electrocardiographic conduction measures; CESC cis rs3126085 0.935 rs6666382 chr1:152217226 C/G cg03465714 chr1:152285911 FLG 0.45 5.37 0.31 1.73e-7 Atopic dermatitis; CESC cis rs7129220 0.588 rs7105321 chr11:10111339 T/C cg01453529 chr11:10209919 SBF2 -0.49 -5.57 -0.32 6.31e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg05025164 chr4:1340916 KIAA1530 -0.7 -9.6 -0.51 6.38e-19 Obesity-related traits; CESC cis rs3087591 0.960 rs2952984 chr17:29469614 T/C cg24425628 chr17:29625626 OMG;NF1 0.41 5.06 0.3 8e-7 Hip circumference; CESC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg17372223 chr3:52568218 NT5DC2 0.44 6.63 0.38 1.86e-10 Bipolar disorder; CESC trans rs11165623 0.765 rs12749081 chr1:96970371 A/C cg10631902 chr5:14652156 NA -0.46 -6.77 -0.38 8.47e-11 Hip circumference;Waist circumference; CESC cis rs7940866 0.834 rs7939417 chr11:130853832 T/A cg12179176 chr11:130786555 SNX19 0.69 10.53 0.54 6.76e-22 Schizophrenia; CESC cis rs12500824 0.564 rs1511818 chr4:77263775 A/C cg20311846 chr4:77356250 SHROOM3 0.4 7.74 0.43 2.07e-13 Coronary artery disease; CESC cis rs897080 0.552 rs1067397 chr2:44679285 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.42 0.32 1.32e-7 Height; CESC cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg14349672 chr11:133703707 NA -0.37 -5.19 -0.3 4.28e-7 Childhood ear infection; CESC cis rs9322193 0.884 rs9383864 chr6:150173105 T/C cg09699651 chr6:150184138 LRP11 0.51 6.43 0.37 5.91e-10 Lung cancer; CESC trans rs1437396 0.657 rs3111413 chr2:55592247 T/C cg07921503 chr7:2445843 CHST12 -0.24 -6.19 -0.36 2.29e-9 Alcohol dependence; CESC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.95 -0.34 8.33e-9 Total body bone mineral density; CESC cis rs9400271 0.632 rs9374069 chr6:109586334 A/G cg01475377 chr6:109611718 NA -0.46 -7.12 -0.4 9.98e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs11758351 0.660 rs11757754 chr6:26219744 A/C cg01420254 chr6:26195488 NA 0.77 8.49 0.46 1.48e-15 Gout;Renal underexcretion gout; CESC cis rs2249625 0.874 rs2496534 chr6:72922550 C/T cg18830697 chr6:72922368 RIMS1 -0.41 -5.74 -0.33 2.54e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs1538970 0.924 rs7531253 chr1:45890183 T/C cg03146154 chr1:46216737 IPP 0.44 5.09 0.3 6.74e-7 Platelet count; CESC cis rs736408 0.677 rs678 chr3:52820981 A/T cg05564831 chr3:52568323 NT5DC2 0.43 6.19 0.36 2.25e-9 Bipolar disorder; CESC trans rs7615952 0.866 rs11922276 chr3:125631326 G/T cg07211511 chr3:129823064 LOC729375 -1.07 -14.34 -0.66 6.43e-35 Blood pressure (smoking interaction); CESC cis rs6831352 0.918 rs34936974 chr4:100052384 A/G cg13256891 chr4:100009986 ADH5 0.62 7.15 0.4 8.48e-12 Alcohol dependence; CESC cis rs2439831 0.571 rs2470121 chr15:43937618 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.69 8.5 0.46 1.35e-15 Lung cancer in ever smokers; CESC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg21782813 chr7:2030301 MAD1L1 0.39 5.56 0.32 6.68e-8 Bipolar disorder and schizophrenia; CESC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg21926612 chr6:163149169 PACRG;PARK2 1.03 10.9 0.56 4.11e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs10506458 1.000 rs73128794 chr12:63445313 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.32 -17.38 -0.73 1.15e-45 Hemostatic factors and hematological phenotypes; CESC cis rs644799 0.965 rs607039 chr11:95547086 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.18e-7 Aortic root size; CESC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.46 -0.32 1.12e-7 Aortic root size; CESC cis rs6565180 0.962 rs6565183 chr16:30382755 T/C cg17640201 chr16:30407289 ZNF48 -0.94 -15.9 -0.7 2e-40 Tonsillectomy; CESC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.01 0.35 6.19e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9875589 0.509 rs6770928 chr3:14077189 G/C cg19554555 chr3:13937349 NA -0.44 -5.62 -0.33 4.74e-8 Ovarian reserve; CESC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg07701084 chr6:150067640 NUP43 0.46 6.25 0.36 1.64e-9 Lung cancer; CESC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.86e-17 Tonsillectomy; CESC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg27532560 chr4:187881888 NA -0.4 -6.08 -0.35 4.1e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg12386194 chr3:101231763 SENP7 0.42 5.28 0.31 2.7e-7 Colorectal cancer; CESC cis rs28830936 0.510 rs11070349 chr15:42085017 A/C cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.33 -5.16 -0.3 4.79e-7 Diastolic blood pressure; CESC cis rs7917772 0.582 rs10786687 chr10:104336994 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.61 0.33 5.05e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs853679 0.882 rs4713140 chr6:28097193 C/T cg23281280 chr6:28129359 ZNF389 0.52 5.32 0.31 2.23e-7 Depression; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16194746 chr8:8341955 NA -0.36 -6.12 -0.35 3.41e-9 Gambling; CESC cis rs4727963 0.792 rs1525468 chr7:122716911 A/C cg03640110 chr7:122635026 TAS2R16 0.41 6.65 0.38 1.62e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg17252645 chr8:143867129 LY6D 0.35 5.98 0.34 7.38e-9 Urinary tract infection frequency; CESC cis rs3733585 0.699 rs7437120 chr4:9967683 T/A cg02734326 chr4:10020555 SLC2A9 -0.4 -5.7 -0.33 3.16e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6964587 0.626 rs10225241 chr7:91524940 A/G cg17063962 chr7:91808500 NA -0.46 -6.48 -0.37 4.55e-10 Breast cancer; CESC cis rs10791097 0.642 rs7107568 chr11:130779668 T/C cg12179176 chr11:130786555 SNX19 0.84 14.53 0.67 1.39e-35 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg11764359 chr7:65958608 NA 0.82 9.61 0.51 6.13e-19 Aortic root size; CESC cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg25019033 chr10:957182 NA -0.57 -6.13 -0.35 3.19e-9 Eosinophil percentage of granulocytes; CESC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg01363902 chr12:121022439 NA -0.5 -6.46 -0.37 4.88e-10 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs77956314 0.515 rs4767473 chr12:117365506 C/T cg02017074 chr12:117425053 FBXW8 0.75 8.23 0.45 8.72e-15 Subcortical brain region volumes;Hippocampal volume; CESC cis rs2228479 0.850 rs17226973 chr16:89825248 T/C cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.34e-11 Skin colour saturation; CESC cis rs9815354 0.904 rs62258655 chr3:41932330 G/A cg03022575 chr3:42003672 ULK4 -0.48 -5.57 -0.32 6.22e-8 Pulse pressure;Diastolic blood pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06551418 chr8:145111391 OPLAH 0.39 6.13 0.35 3.17e-9 Gambling; CESC cis rs80282103 0.618 rs11250264 chr10:1151723 A/C cg08668510 chr10:1095578 IDI1 0.77 6.35 0.36 9.51e-10 Glomerular filtration rate (creatinine); CESC cis rs7336332 0.598 rs77055070 chr13:28010516 C/G cg01674679 chr13:27998804 GTF3A -0.58 -5.34 -0.31 2.04e-7 Weight; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13649242 chr6:170893854 PDCD2 0.59 6.53 0.37 3.26e-10 Gut microbiome composition (summer); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg22577136 chr1:206644165 IKBKE -0.42 -6.27 -0.36 1.46e-9 Vertical cup-disc ratio; CESC cis rs4764124 0.646 rs10744078 chr12:14978535 T/G cg19759883 chr12:14956454 WBP11;C12orf60 -0.59 -8.46 -0.46 1.82e-15 Pubertal anthropometrics; CESC cis rs7208859 0.673 rs9915139 chr17:29158515 A/G cg13385521 chr17:29058706 SUZ12P 0.75 5.84 0.34 1.55e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9814567 1.000 rs2370642 chr3:134222136 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.46 -6.28 -0.36 1.37e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6815814 0.950 rs45588337 chr4:38807328 A/G cg02016764 chr4:38805732 TLR1 -0.63 -7.26 -0.41 4.22e-12 Breast cancer; CESC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg06028808 chr11:68637592 NA 0.45 5.38 0.31 1.64e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6063312 1.000 rs6063312 chr20:47343059 G/T cg18078177 chr20:47281410 PREX1 0.55 5.53 0.32 7.54e-8 Tonometry; CESC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1109430 0.661 rs11119403 chr1:210249847 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.23 0.36 1.82e-9 Orofacial clefts; CESC cis rs4727027 0.635 rs12111923 chr7:148885877 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 5.25 0.31 3.17e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6674176 0.660 rs12726706 chr1:44399942 G/A cg15962314 chr1:44399869 ARTN 0.28 5.14 0.3 5.46e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14977279 chr14:105609411 JAG2 0.52 6.78 0.38 7.67e-11 Fibrinogen levels; CESC cis rs12477438 0.798 rs4850891 chr2:99574642 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.22 -0.53 6.79e-21 Chronic sinus infection; CESC cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.42 -6.88 -0.39 4.31e-11 Personality dimensions; CESC cis rs61759167 1.000 rs61759167 chr1:3091587 C/T cg01961086 chr1:3086487 PRDM16 -0.34 -5.06 -0.3 8.02e-7 Motion sickness; CESC cis rs6582630 0.555 rs1906260 chr12:38601013 T/G cg13010199 chr12:38710504 ALG10B 0.53 6.86 0.39 4.71e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg24733560 chr20:60626293 TAF4 0.38 5.41 0.32 1.44e-7 Body mass index; CESC cis rs4654899 1.000 rs6426656 chr1:21343245 G/C cg05370193 chr1:21551575 ECE1 0.41 6.16 0.35 2.64e-9 Superior frontal gyrus grey matter volume; CESC cis rs9287719 0.967 rs6706542 chr2:10742491 A/C cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs559928 0.606 rs55942618 chr11:63936005 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.84 0.34 1.55e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs2204008 0.614 rs4578492 chr12:38036350 T/C cg26384229 chr12:38710491 ALG10B 0.75 10.72 0.55 1.61e-22 Bladder cancer; CESC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg07701084 chr6:150067640 NUP43 0.43 5.85 0.34 1.45e-8 Lung cancer; CESC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg21784768 chr11:537496 LRRC56 -0.54 -5.07 -0.3 7.31e-7 Body mass index; CESC cis rs763014 0.865 rs710924 chr16:633353 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC cis rs7216064 1.000 rs4318247 chr17:65882172 A/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.82 -0.48 1.55e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1775715 0.707 rs2778669 chr10:32161541 C/T cg18675610 chr10:32216311 ARHGAP12 0.35 5.38 0.31 1.6e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs12142240 0.698 rs6696777 chr1:46810970 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.85 0.43 1.05e-13 Menopause (age at onset); CESC cis rs8022179 0.580 rs8013228 chr14:103842650 A/G cg12935359 chr14:103987150 CKB -0.48 -6.22 -0.36 1.95e-9 Monocyte count; CESC cis rs601339 0.877 rs2649991 chr12:123179461 A/G cg11919336 chr12:123188078 GPR109A 0.48 6.44 0.37 5.44e-10 Adiponectin levels; CESC cis rs7202877 0.656 rs4888394 chr16:75413709 T/C cg04384234 chr16:75411784 CFDP1 -0.49 -5.89 -0.34 1.16e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs2549003 0.966 rs10072571 chr5:131816711 A/C cg02551604 chr5:131831745 NA -0.37 -5.22 -0.31 3.53e-7 Asthma (sex interaction); CESC cis rs2456568 0.867 rs7114457 chr11:93657817 C/T cg26875233 chr11:93583750 C11orf90 -0.3 -5.16 -0.3 4.77e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs11190604 1.000 rs4919466 chr10:102241213 T/C cg07080220 chr10:102295463 HIF1AN 0.56 5.54 0.32 7.32e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs1048238 0.506 rs848212 chr1:16263452 A/G cg22431228 chr1:16359049 CLCNKA 0.37 6.59 0.38 2.43e-10 Systolic blood pressure; CESC cis rs9818758 0.545 rs9853352 chr3:49813258 C/T cg00383909 chr3:49044727 WDR6 -0.83 -5.69 -0.33 3.42e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg22638593 chr5:131593259 PDLIM4 0.39 5.07 0.3 7.6e-7 Breast cancer; CESC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.52 7.55 0.42 6.86e-13 Bipolar disorder; CESC cis rs3925075 0.966 rs7195915 chr16:31344455 A/G cg02846316 chr16:31340340 ITGAM 0.42 6.76 0.38 8.91e-11 IgA nephropathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21638323 chr11:47600536 KBTBD4;NDUFS3 0.54 6.05 0.35 4.79e-9 Gut microbiome composition (summer); CESC cis rs9532580 0.619 rs2755211 chr13:41142223 C/T cg21288729 chr13:41239152 FOXO1 0.67 7.94 0.44 5.69e-14 Mean corpuscular hemoglobin; CESC cis rs9549260 0.522 rs4245401 chr13:41277736 G/T cg21288729 chr13:41239152 FOXO1 0.57 7.59 0.42 5.49e-13 Red blood cell count; CESC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2952156 0.920 rs2517953 chr17:37841211 G/C cg00129232 chr17:37814104 STARD3 -0.81 -11.91 -0.59 1.71e-26 Asthma; CESC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs9527 0.590 rs12414232 chr10:104914491 A/T cg04362960 chr10:104952993 NT5C2 0.43 5.33 0.31 2.12e-7 Arsenic metabolism; CESC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg11644478 chr21:40555479 PSMG1 1.01 15.97 0.7 1.12e-40 Cognitive function; CESC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg16325326 chr1:53192061 ZYG11B -0.71 -11.84 -0.59 3e-26 Monocyte count; CESC cis rs761746 0.921 rs7291918 chr22:32008039 A/G cg25791279 chr22:32026902 PISD 0.58 6.83 0.39 5.84e-11 Intelligence; CESC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg08027265 chr7:2291960 NA -0.41 -6.39 -0.37 7.45e-10 Schizophrenia; CESC cis rs6120849 0.754 rs6088682 chr20:33615702 A/C cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15464363 chr22:32149800 DEPDC5 -0.4 -6.47 -0.37 4.79e-10 Gambling; CESC cis rs2230307 0.572 rs512999 chr1:100563330 A/G cg24955406 chr1:100503596 HIAT1 0.53 5.25 0.31 3.18e-7 Carotid intima media thickness; CESC cis rs2243480 1.000 rs6959002 chr7:65650496 A/G cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.24e-32 Diabetic kidney disease; CESC cis rs4072980 0.524 rs28442147 chr1:38395410 T/A cg17077180 chr1:38461687 NA 0.43 6.14 0.35 3e-9 Coronary artery disease; CESC cis rs870825 0.616 rs7678849 chr4:185648868 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs1971256 0.500 rs75278317 chr6:151821271 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.64 5.89 0.34 1.14e-8 Endometriosis; CESC cis rs2952156 0.920 rs8078228 chr17:37834998 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.1 -0.3 6.37e-7 Asthma; CESC cis rs9473147 0.516 rs2171089 chr6:47515811 A/G cg20196966 chr6:47445060 CD2AP 0.4 5.18 0.3 4.45e-7 Platelet distribution width;Mean platelet volume; CESC cis rs4862750 0.872 rs7664463 chr4:187876686 A/C cg06074448 chr4:187884817 NA -0.46 -6.87 -0.39 4.56e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs13064411 0.735 rs6438157 chr3:113207316 G/T cg18753928 chr3:113234510 CCDC52 -0.52 -6.31 -0.36 1.17e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs9039 1.000 rs56193985 chr16:9207199 C/A cg08831531 chr16:9218945 NA -0.52 -7.11 -0.4 1.07e-11 Menopause (age at onset); CESC trans rs2823962 0.759 rs2823933 chr21:18022418 G/T cg06419850 chr17:4688683 VMO1 -0.44 -6.23 -0.36 1.83e-9 Amyotrophic lateral sclerosis; CESC cis rs9318086 0.712 rs3794339 chr13:24434065 A/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.41 5.34 0.31 1.98e-7 Myopia (pathological); CESC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg04414720 chr1:150670196 GOLPH3L 0.54 7.13 0.4 9.67e-12 Melanoma; CESC cis rs4969178 0.965 rs11653305 chr17:76386918 T/C cg20026190 chr17:76395443 PGS1 0.44 6.83 0.39 5.8e-11 HDL cholesterol levels; CESC cis rs13191362 1.000 rs13212608 chr6:163032128 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.86 9.12 0.49 1.91e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg00409905 chr10:38381863 ZNF37A -0.45 -5.96 -0.34 7.89e-9 Extrinsic epigenetic age acceleration; CESC cis rs3087591 1.000 rs9904169 chr17:29572518 C/T cg24425628 chr17:29625626 OMG;NF1 -0.42 -5.03 -0.3 9.19e-7 Hip circumference; CESC trans rs4132509 0.793 rs10927047 chr1:243803677 A/T cg11709150 chr1:2440438 PANK4 0.62 6.47 0.37 4.67e-10 RR interval (heart rate); CESC cis rs71403859 0.667 rs12149264 chr16:71720921 T/G cg08717414 chr16:71523259 ZNF19 -0.71 -6.24 -0.36 1.73e-9 Post bronchodilator FEV1; CESC trans rs7615952 0.515 rs7630575 chr3:125682330 A/G cg07211511 chr3:129823064 LOC729375 -0.62 -6.44 -0.37 5.46e-10 Blood pressure (smoking interaction); CESC cis rs963731 0.522 rs1454222 chr2:39215895 C/A cg04010122 chr2:39346883 SOS1 -0.7 -5.22 -0.31 3.64e-7 Corticobasal degeneration; CESC cis rs34779708 0.931 rs12771399 chr10:35452377 C/T cg04310649 chr10:35416472 CREM -0.54 -6.53 -0.37 3.25e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs425277 1.000 rs262641 chr1:2104981 C/T cg24578937 chr1:2090814 PRKCZ -0.5 -8.83 -0.48 1.48e-16 Height; CESC cis rs4237845 0.514 rs4760339 chr12:58268149 G/T cg00677455 chr12:58241039 CTDSP2 0.8 10.71 0.55 1.76e-22 Intelligence (multi-trait analysis); CESC cis rs17818399 1.000 rs62136864 chr2:46829124 G/A cg06386533 chr2:46925753 SOCS5 0.5 5.77 0.33 2.24e-8 Height; CESC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg20790798 chr5:1857306 NA -0.38 -5.11 -0.3 6.21e-7 Cardiovascular disease risk factors; CESC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg08859206 chr1:53392774 SCP2 0.67 10.45 0.54 1.28e-21 Monocyte count; CESC cis rs10046574 0.831 rs10239457 chr7:135116926 A/G cg27474649 chr7:135195673 CNOT4 -0.68 -5.34 -0.31 2e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7208859 0.623 rs11658022 chr17:29085359 A/T cg14008862 chr17:28927542 LRRC37B2 0.68 5.3 0.31 2.47e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9611519 0.780 rs5751071 chr22:41656332 G/A cg03806693 chr22:41940476 POLR3H -0.55 -6.27 -0.36 1.46e-9 Neuroticism; CESC cis rs7937682 0.632 rs11603779 chr11:111781047 A/C cg09085632 chr11:111637200 PPP2R1B 0.88 11.23 0.57 3.51e-24 Primary sclerosing cholangitis; CESC cis rs76878669 0.606 rs1785639 chr11:66100430 G/A cg18002602 chr11:66138449 SLC29A2 0.41 6.73 0.38 1.08e-10 Educational attainment (years of education); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg15926737 chr12:57853737 GLI1 -0.5 -6.47 -0.37 4.71e-10 Height; CESC cis rs853679 0.505 rs200992 chr6:27814677 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.8 6.51 0.37 3.8e-10 Depression; CESC cis rs6964587 0.773 rs59242586 chr7:91918145 A/G cg17063962 chr7:91808500 NA 0.53 6.78 0.38 7.95e-11 Breast cancer; CESC cis rs1728785 0.901 rs7194664 chr16:68643313 T/C cg02972257 chr16:68554789 NA -0.63 -7.0 -0.39 2.14e-11 Ulcerative colitis; CESC cis rs1355223 0.902 rs1453380 chr11:34703682 C/G cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.15 -0.35 2.82e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs1023500 0.529 rs133375 chr22:42466509 C/G cg15557168 chr22:42548783 NA -0.45 -6.5 -0.37 3.87e-10 Schizophrenia; CESC cis rs6688363 0.943 rs1016732 chr1:160086968 A/G cg01023271 chr1:160068607 IGSF8 0.55 5.4 0.31 1.48e-7 Response to antipsychotic treatment; CESC cis rs769267 0.501 rs2965187 chr19:19522970 T/A cg11584989 chr19:19387371 SF4 0.54 6.77 0.38 8.41e-11 Tonsillectomy; CESC cis rs472402 0.580 rs10060745 chr5:6658003 T/C cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.54 -7.01 -0.4 2e-11 Response to amphetamines; CESC cis rs599083 0.530 rs2508834 chr11:68175354 C/T cg16797656 chr11:68205561 LRP5 -0.4 -5.33 -0.31 2.1e-7 Bone mineral density (spine); CESC cis rs7772486 0.875 rs9373483 chr6:146364194 A/G cg05347473 chr6:146136440 FBXO30 0.47 6.16 0.35 2.66e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs9291683 0.588 rs2240722 chr4:10020757 A/G cg00071950 chr4:10020882 SLC2A9 0.92 17.72 0.74 6.98e-47 Bone mineral density; CESC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg02187348 chr16:89574699 SPG7 0.64 8.99 0.48 4.91e-17 Multiple myeloma (IgH translocation); CESC cis rs4563143 0.675 rs56407818 chr19:29279379 G/A cg12667521 chr19:29218732 NA 0.5 6.39 0.37 7.47e-10 Methadone dose in opioid dependence; CESC cis rs2625529 0.652 rs9302260 chr15:72174611 T/C cg16672083 chr15:72433130 SENP8 0.45 6.72 0.38 1.09e-10 Red blood cell count; CESC cis rs751837 0.591 rs10138056 chr14:103424854 A/G cg10087771 chr14:103399429 CDC42BPB 0.7 6.09 0.35 4.01e-9 Large B-cell lymphoma; CESC cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1003719 0.762 rs8130846 chr21:38480242 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg21782813 chr7:2030301 MAD1L1 0.5 7.24 0.41 4.74e-12 Bipolar disorder and schizophrenia; CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg18591801 chr3:52553433 STAB1 -0.3 -5.76 -0.33 2.27e-8 Electroencephalogram traits; CESC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.583 rs7207043 chr17:17819188 A/G cg09796270 chr17:17721594 SREBF1 0.42 5.95 0.34 8.29e-9 Total body bone mineral density; CESC trans rs877282 0.891 rs12767062 chr10:797961 C/T cg22713356 chr15:30763199 NA 1.35 13.42 0.64 1.08e-31 Uric acid levels; CESC cis rs2933343 0.649 rs789216 chr3:128594503 A/C cg24203234 chr3:128598194 ACAD9 0.4 5.34 0.31 2.05e-7 IgG glycosylation; CESC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg18904891 chr8:8559673 CLDN23 0.7 8.19 0.45 1.14e-14 Obesity-related traits; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22332891 chr1:178995082 FAM20B -0.5 -6.19 -0.36 2.32e-9 Ulcerative colitis; CESC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg08888203 chr3:10149979 C3orf24 0.48 6.0 0.35 6.49e-9 Alzheimer's disease; CESC cis rs7808935 0.958 rs17156041 chr7:27975745 C/T cg05786569 chr7:27702416 HIBADH 0.46 5.08 0.3 7.17e-7 Prostate cancer; CESC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg12311346 chr5:56204834 C5orf35 0.87 10.66 0.55 2.52e-22 Initial pursuit acceleration; CESC cis rs662064 0.962 rs2506902 chr1:10563681 C/T cg20482658 chr1:10539492 PEX14 0.37 7.15 0.4 8.25e-12 Asthma; CESC cis rs1983891 0.955 rs6917270 chr6:41548755 A/G cg20194872 chr6:41519635 FOXP4 0.53 7.46 0.42 1.21e-12 Prostate cancer; CESC cis rs9596863 1.000 rs9596859 chr13:54431200 T/A ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg09737314 chr17:6899359 ALOX12 -0.47 -8.29 -0.45 5.81e-15 Tonsillectomy; CESC cis rs12477438 0.501 rs7608938 chr2:99782226 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.62 0.61 6.6e-29 Chronic sinus infection; CESC cis rs5747327 0.874 rs5747333 chr22:18180567 G/C cg19898043 chr22:18121309 BCL2L13 -0.4 -5.19 -0.3 4.18e-7 Myeloid white cell count;Granulocyte count; CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg23131131 chr22:24373011 LOC391322 0.72 10.04 0.52 2.65e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs151234 0.676 rs554206 chr16:28576369 G/A cg01378222 chr16:28622494 SULT1A1 -0.57 -7.19 -0.4 6.79e-12 Platelet distribution width; CESC cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg05368731 chr17:41323189 NBR1 0.59 8.21 0.45 9.98e-15 Menopause (age at onset); CESC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2795502 0.882 rs2744091 chr10:43339441 A/G cg20628663 chr10:43360327 NA -0.62 -7.39 -0.41 1.9e-12 Blood protein levels; CESC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.18 0.3 4.4e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.954 rs10518328 chr4:120401779 G/A cg24375607 chr4:120327624 NA 0.45 5.49 0.32 9.3e-8 Corneal astigmatism; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg18330637 chr20:18548049 LOC388789 -0.45 -6.0 -0.35 6.41e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2710642 0.611 rs1534420 chr2:62884053 C/T cg17519650 chr2:63277830 OTX1 -0.46 -5.44 -0.32 1.23e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs7077164 1.000 rs1227769 chr10:71586296 C/T cg07630274 chr10:71583235 COL13A1 -0.38 -6.99 -0.39 2.27e-11 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs11711311 1.000 rs9848993 chr3:113497914 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.73 10.32 0.54 3.29e-21 IgG glycosylation; CESC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg08968635 chr6:28129556 ZNF389 0.42 5.72 0.33 2.82e-8 Depression; CESC cis rs7589342 0.929 rs2060036 chr2:106436101 G/A cg16077055 chr2:106428750 NCK2 0.54 7.64 0.42 4.08e-13 Addiction; CESC trans rs4942242 0.626 rs7986998 chr13:44209916 G/A cg19169023 chr15:41853346 TYRO3 0.56 7.1 0.4 1.18e-11 Response to tocilizumab in rheumatoid arthritis; CESC cis rs28647808 1.000 rs28591209 chr9:136259668 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21951679 chr5:178977648 RUFY1 0.47 6.19 0.36 2.23e-9 Gut microbiome composition (summer); CESC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.7 -8.04 -0.44 2.93e-14 Alzheimer's disease; CESC cis rs3806843 0.676 rs2563304 chr5:140072057 C/T cg26395211 chr5:140044315 WDR55 0.47 5.95 0.34 8.29e-9 Depressive symptoms (multi-trait analysis); CESC cis rs77741769 0.571 rs3861797 chr12:121255334 T/C cg02419362 chr12:121203948 SPPL3 0.35 5.69 0.33 3.37e-8 Mean corpuscular volume; CESC cis rs7618501 0.516 rs2856236 chr3:50161717 A/C cg24110177 chr3:50126178 RBM5 0.5 6.71 0.38 1.2e-10 Intelligence (multi-trait analysis); CESC cis rs6430585 0.583 rs79633114 chr2:136586825 C/T cg07169764 chr2:136633963 MCM6 1.34 19.5 0.77 3.91e-53 Corneal structure; CESC cis rs9467711 0.606 rs9379900 chr6:26603811 A/C cg21479132 chr6:26055353 NA 0.65 5.69 0.33 3.29e-8 Autism spectrum disorder or schizophrenia; CESC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC cis rs1912483 0.545 rs35161461 chr17:45401757 A/G cg25173405 chr17:45401733 C17orf57 -0.49 -5.72 -0.33 2.85e-8 Coronary artery disease; CESC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg14159672 chr1:205819179 PM20D1 0.81 12.95 0.62 4.67e-30 Menarche (age at onset); CESC cis rs74181299 0.964 rs2540951 chr2:65276736 A/G cg05010058 chr2:65284262 CEP68 0.31 5.56 0.32 6.63e-8 Pulse pressure; CESC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg12412775 chr1:25698385 RHCE -0.31 -5.62 -0.33 4.72e-8 Erythrocyte sedimentation rate; CESC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.8 0.65 5.28e-33 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07588614 chr3:113604183 GRAMD1C 0.45 6.38 0.36 8.08e-10 Fibrinogen levels; CESC trans rs4332037 0.539 rs11772627 chr7:2109821 G/C cg11693508 chr17:37793320 STARD3 0.68 6.92 0.39 3.42e-11 Bipolar disorder; CESC cis rs4253772 0.678 rs1055659 chr22:46638298 C/T cg09491104 chr22:46646882 C22orf40 -0.44 -5.83 -0.34 1.59e-8 LDL cholesterol;Cholesterol, total; CESC cis rs12458462 0.892 rs3786228 chr18:77464170 C/T cg23301140 chr18:77439876 CTDP1 -0.58 -8.07 -0.44 2.47e-14 Monocyte count; CESC cis rs8022179 0.580 rs6575977 chr14:103823348 G/T cg12935359 chr14:103987150 CKB 0.53 6.46 0.37 5.11e-10 Monocyte count; CESC cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg13902645 chr11:5959945 NA -0.6 -7.38 -0.41 2.03e-12 DNA methylation (variation); CESC cis rs77956314 0.515 rs4238051 chr12:117366299 A/G cg25972092 chr12:117363249 FBXW8 0.53 5.69 0.33 3.36e-8 Subcortical brain region volumes;Hippocampal volume; CESC cis rs6543140 0.964 rs4851593 chr2:103089227 C/T cg04239558 chr2:103089729 SLC9A4 -0.48 -6.21 -0.36 2.09e-9 Blood protein levels; CESC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg03647317 chr4:187891568 NA 0.41 6.05 0.35 4.83e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs7085104 0.572 rs284860 chr10:104572963 T/C cg04362960 chr10:104952993 NT5C2 -0.47 -6.37 -0.36 8.35e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.09 21.08 0.79 1.38e-58 Prudent dietary pattern; CESC cis rs6032067 0.852 rs6032046 chr20:43823679 A/G cg10761708 chr20:43804764 PI3 0.53 6.36 0.36 8.83e-10 Blood protein levels; CESC cis rs9796 0.689 rs13329537 chr15:41449211 C/G cg09898695 chr15:41135793 SPINT1 0.21 5.04 0.3 8.66e-7 Menopause (age at onset); CESC cis rs34779708 0.931 rs2001893 chr10:35300623 G/A cg03585969 chr10:35415529 CREM 0.75 9.89 0.52 7.5599999999999994e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7312774 0.618 rs3759317 chr12:107370252 T/C cg16260113 chr12:107380972 MTERFD3 0.81 7.18 0.4 7.13e-12 Severe influenza A (H1N1) infection; CESC cis rs4727963 0.846 rs1464875 chr7:122729085 G/A cg03640110 chr7:122635026 TAS2R16 -0.37 -5.55 -0.32 6.79e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Parkinson's disease; CESC cis rs244293 0.965 rs244357 chr17:53193181 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.03 -0.3 9.21e-7 Menarche (age at onset); CESC cis rs2479106 0.791 rs2670139 chr9:126634255 T/C cg16191174 chr9:126692580 DENND1A 0.49 6.62 0.38 2.02e-10 Polycystic ovary syndrome; CESC cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg20476274 chr7:133979776 SLC35B4 0.63 9.08 0.49 2.53e-17 Mean platelet volume; CESC cis rs1153858 1.000 rs1980288 chr15:45620612 T/C cg14582100 chr15:45693742 SPATA5L1 0.41 5.71 0.33 3.08e-8 Homoarginine levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23411981 chr14:105940377 CRIP2 0.45 6.21 0.36 2.09e-9 Fibrinogen levels; CESC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg11764359 chr7:65958608 NA 0.96 15.21 0.68 5.68e-38 Aortic root size; CESC cis rs2040771 0.711 rs361639 chr22:19268024 A/G cg17887427 chr22:19166691 SLC25A1 -0.39 -5.13 -0.3 5.55e-7 Metabolite levels (small molecules and protein measures); CESC cis rs12477438 0.765 rs2309454 chr2:99595418 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg05564831 chr3:52568323 NT5DC2 0.46 7.19 0.4 6.64e-12 Bipolar disorder; CESC cis rs7223966 1.000 rs7222060 chr17:61868279 C/T cg11494091 chr17:61959527 GH2 0.38 5.17 0.3 4.56e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs3820068 0.581 rs72645861 chr1:15920314 A/G cg13390004 chr1:15929781 NA 0.33 5.04 0.3 8.45e-7 Systolic blood pressure; CESC trans rs2727020 0.553 rs11040400 chr11:49518296 C/A cg03929089 chr4:120376271 NA -0.8 -11.78 -0.59 5.03e-26 Coronary artery disease; CESC trans rs11098499 0.954 rs10031665 chr4:120422852 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.78 0.51 1.7e-19 Corneal astigmatism; CESC cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg05234568 chr11:5960015 NA -0.56 -6.42 -0.37 6.24e-10 DNA methylation (variation); CESC cis rs6502050 0.835 rs4789732 chr17:80131382 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.97e-7 Life satisfaction; CESC cis rs8180040 0.620 rs6767907 chr3:47162661 C/T cg27129171 chr3:47204927 SETD2 -0.64 -9.54 -0.51 9.72e-19 Colorectal cancer; CESC cis rs897080 0.518 rs1067330 chr2:44627822 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.82 0.34 1.67e-8 Height; CESC cis rs17253792 0.731 rs8008528 chr14:56062052 C/T cg01858014 chr14:56050164 KTN1 -0.96 -7.13 -0.4 9.72e-12 Putamen volume; CESC trans rs9929218 0.911 rs4783685 chr16:68834107 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.64 -8.06 -0.44 2.61e-14 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18898693 chr10:80829147 ZMIZ1 -0.6 -6.34 -0.36 9.75e-10 Gut microbiome composition (summer); CESC cis rs820218 0.926 rs820205 chr17:73641052 A/T cg01592526 chr17:73663357 RECQL5;SAP30BP 0.44 6.15 0.35 2.9e-9 Rotator cuff tears; CESC cis rs796364 0.901 rs4673762 chr2:201065171 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.6 5.61 0.33 5e-8 Schizophrenia; CESC cis rs16854884 0.657 rs1867608 chr3:143752938 G/A cg06585982 chr3:143692056 C3orf58 0.5 6.64 0.38 1.78e-10 Economic and political preferences (feminism/equality); CESC cis rs2046867 0.862 rs57396880 chr3:72844785 G/A cg25664220 chr3:72788482 NA -0.47 -6.77 -0.38 8.26e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg22974920 chr21:40686053 BRWD1 -0.45 -5.57 -0.32 6.21e-8 Cognitive function; CESC cis rs6963495 0.649 rs1706888 chr7:105149176 A/G cg13798780 chr7:105162888 PUS7 0.5 6.09 0.35 4.04e-9 Bipolar disorder (body mass index interaction); CESC cis rs2073300 0.609 rs6137945 chr20:23406136 C/T cg16736954 chr20:23401023 NAPB 0.78 5.69 0.33 3.37e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs11098499 0.863 rs1010740 chr4:120463409 C/T cg25214090 chr10:38739885 LOC399744 -0.69 -9.33 -0.5 4.5e-18 Corneal astigmatism; CESC cis rs9326248 0.530 rs2000614 chr11:116915742 C/T cg01368799 chr11:117014884 PAFAH1B2 0.56 5.18 0.3 4.38e-7 Blood protein levels; CESC cis rs12142240 0.698 rs72679807 chr1:46846490 G/A cg10495392 chr1:46806563 NSUN4 0.56 6.15 0.35 2.86e-9 Menopause (age at onset); CESC cis rs2404602 0.669 rs1875885 chr15:76638081 G/A cg26408565 chr15:76604113 ETFA -0.42 -5.98 -0.34 7.26e-9 Blood metabolite levels; CESC cis rs2820292 0.678 rs4309038 chr1:201884647 C/G cg06775570 chr1:201857621 SHISA4 -0.31 -5.15 -0.3 5.1e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg05368731 chr17:41323189 NBR1 0.8 11.35 0.57 1.34e-24 Menopause (age at onset); CESC cis rs2276314 0.857 rs28791905 chr18:33602213 G/A cg05985134 chr18:33552581 C18orf21 0.58 6.69 0.38 1.35e-10 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7116495 0.609 rs1541304 chr11:71714078 T/C cg10381502 chr11:71823885 C11orf51 -1.16 -7.72 -0.43 2.32e-13 Severe influenza A (H1N1) infection; CESC cis rs12541635 0.966 rs2059943 chr8:107071607 G/T cg10147462 chr8:107024639 NA 0.38 5.33 0.31 2.14e-7 Age of smoking initiation; CESC cis rs826838 0.935 rs7301104 chr12:39182821 C/T cg13010199 chr12:38710504 ALG10B 0.58 8.05 0.44 2.77e-14 Heart rate; CESC cis rs17270561 1.000 rs17270561 chr6:25820439 A/C cg17691542 chr6:26056736 HIST1H1C -0.62 -7.26 -0.41 4.29e-12 Iron status biomarkers; CESC cis rs644799 0.965 rs565771 chr11:95644179 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.61 7.98 0.44 4.42e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9916302 0.605 rs2879258 chr17:37399379 G/T cg07936489 chr17:37558343 FBXL20 -0.88 -8.84 -0.48 1.34e-16 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01062786 chr14:20929651 TMEM55B 0.55 6.69 0.38 1.29e-10 Gut microbiome composition (summer); CESC cis rs826838 1.000 rs826886 chr12:39095797 A/G cg26384229 chr12:38710491 ALG10B 0.62 10.11 0.53 1.55e-20 Heart rate; CESC cis rs2710642 0.576 rs1872789 chr2:62883470 A/C cg17519650 chr2:63277830 OTX1 0.44 5.26 0.31 2.91e-7 LDL cholesterol levels;LDL cholesterol; CESC trans rs526821 0.595 rs551665 chr11:55343268 G/A cg15704280 chr7:45808275 SEPT13 -0.54 -6.69 -0.38 1.32e-10 Pediatric bone mineral density (spine); CESC cis rs11190604 1.000 rs2489053 chr10:102353341 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.64 0.33 4.39e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs11785693 0.909 rs62489556 chr8:4968149 G/A cg26367366 chr8:4980734 NA 0.86 7.35 0.41 2.48e-12 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs5760092 0.755 rs4585126 chr22:24270005 T/C cg12419862 chr22:24373484 LOC391322 0.75 9.8 0.52 1.49e-19 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs3008870 0.920 rs2755253 chr1:67470843 C/T cg02640540 chr1:67518911 SLC35D1 0.47 5.7 0.33 3.26e-8 Lymphocyte percentage of white cells; CESC cis rs9287719 0.967 rs6727768 chr2:10757479 T/C cg02196655 chr2:10830764 NOL10 -0.37 -5.67 -0.33 3.73e-8 Prostate cancer; CESC cis rs35110281 0.666 rs9977076 chr21:45085829 G/A cg01579765 chr21:45077557 HSF2BP -0.54 -9.12 -0.49 1.95e-17 Mean corpuscular volume; CESC cis rs1034435 0.755 rs713923 chr22:48891519 C/T cg05992904 chr22:48892994 FAM19A5 0.52 8.28 0.45 6.13e-15 Late-onset Alzheimer's disease; CESC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg08888203 chr3:10149979 C3orf24 0.49 6.17 0.35 2.49e-9 Alzheimer's disease; CESC trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg00717180 chr2:96193071 NA -0.46 -6.19 -0.36 2.23e-9 HDL cholesterol; CESC cis rs7107174 1.000 rs12270434 chr11:78103300 G/A cg02023728 chr11:77925099 USP35 0.39 5.45 0.32 1.14e-7 Testicular germ cell tumor; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg11646757 chr7:128095699 C7orf68 -0.48 -6.42 -0.37 6.33e-10 Height; CESC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.97 0.34 7.51e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg05368731 chr17:41323189 NBR1 0.78 10.53 0.54 6.98e-22 Menopause (age at onset); CESC cis rs2777491 0.915 rs8036498 chr15:41603276 A/G cg02330683 chr15:41787940 ITPKA 0.46 6.76 0.38 8.67e-11 Ulcerative colitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03200734 chr16:67235732 ELMO3 0.5 7.28 0.41 3.7e-12 Fibrinogen levels; CESC cis rs611744 0.604 rs13248461 chr8:109285833 C/T cg21045802 chr8:109455806 TTC35 0.52 6.46 0.37 5.03e-10 Dupuytren's disease; CESC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg21784768 chr11:537496 LRRC56 -0.55 -5.12 -0.3 5.99e-7 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21528620 chr1:110753221 KCNC4 -0.43 -6.3 -0.36 1.2e-9 Fibrinogen levels; CESC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg25036284 chr2:26402008 FAM59B 0.64 7.22 0.41 5.55e-12 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs7223438 chr17:37521355 T/C cg20243544 chr17:37824526 PNMT -0.48 -5.79 -0.34 1.96e-8 Glomerular filtration rate (creatinine); CESC cis rs10131894 0.611 rs174994 chr14:75434102 A/G cg08847533 chr14:75593920 NEK9 -0.75 -11.77 -0.59 5.43e-26 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07154754 chr12:132514292 SNORA49;EP400 0.5 7.36 0.41 2.37e-12 Fibrinogen levels; CESC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs4718428 0.705 rs2901311 chr7:66415069 T/C cg12165864 chr7:66369176 NA -0.67 -7.64 -0.42 3.91e-13 Corneal structure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23226134 chr1:11866389 CLCN6;MTHFR -0.48 -6.76 -0.38 8.95e-11 Gut microbiota (bacterial taxa); CESC cis rs7937682 0.632 rs10891294 chr11:111699224 C/T cg09085632 chr11:111637200 PPP2R1B 0.85 10.37 0.54 2.32e-21 Primary sclerosing cholangitis; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg01172656 chr10:64893120 NRBF2 0.45 6.07 0.35 4.46e-9 Weight; CESC cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg01579765 chr21:45077557 HSF2BP -0.55 -9.27 -0.49 6.73e-18 Mean corpuscular volume; CESC cis rs17376456 0.877 rs35075119 chr5:93385457 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.36 0.31 1.8e-7 Diabetic retinopathy; CESC trans rs3942852 0.759 rs905475 chr11:48149755 C/T cg03929089 chr4:120376271 NA -0.57 -6.31 -0.36 1.15e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs9811920 0.965 rs6767441 chr3:99863183 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.43 5.58 0.32 5.99e-8 Axial length; CESC cis rs7223966 0.921 rs67018565 chr17:61928055 C/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.14 -0.3 5.24e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs644799 1.000 rs651445 chr11:95539122 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4835473 0.932 rs3872 chr4:144889941 C/T cg25736465 chr4:144833511 NA 0.38 5.77 0.33 2.2e-8 Immature fraction of reticulocytes; CESC trans rs2727020 0.729 rs2866328 chr11:49282421 A/G cg15704280 chr7:45808275 SEPT13 0.87 14.38 0.66 4.84e-35 Coronary artery disease; CESC cis rs7264396 0.676 rs1341603 chr20:34556216 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.09 0.35 4.04e-9 Total cholesterol levels; CESC cis rs863345 0.967 rs863359 chr1:158544733 A/C cg12129480 chr1:158549410 OR10X1 -0.31 -6.29 -0.36 1.31e-9 Pneumococcal bacteremia; CESC cis rs10242455 0.702 rs73397499 chr7:99039627 T/C cg25640893 chr7:99214727 ZNF498 0.72 5.11 0.3 6.25e-7 Blood metabolite levels; CESC cis rs9487051 0.676 rs9400267 chr6:109600164 T/C cg21918786 chr6:109611834 NA -0.39 -5.67 -0.33 3.79e-8 Reticulocyte fraction of red cells; CESC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg04518342 chr5:131593106 PDLIM4 -0.36 -5.07 -0.3 7.31e-7 Acylcarnitine levels; CESC cis rs1707322 0.721 rs10890343 chr1:46157922 C/T cg05343316 chr1:45956843 TESK2 0.5 6.28 0.36 1.38e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6026584 1.000 rs6026584 chr20:57469073 C/T cg11480267 chr20:57463503 GNAS -0.48 -5.94 -0.34 8.96e-9 Renal function-related traits (BUN); CESC cis rs9611565 0.571 rs2050032 chr22:42152429 C/T cg06634786 chr22:41940651 POLR3H 0.48 5.42 0.32 1.32e-7 Vitiligo; CESC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg03709012 chr19:19516395 GATAD2A 1.01 15.89 0.7 2.1e-40 Tonsillectomy; CESC cis rs9905704 0.846 rs302863 chr17:56698827 A/G cg12560992 chr17:57184187 TRIM37 -0.58 -7.15 -0.4 8.63e-12 Testicular germ cell tumor; CESC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.25 0.53 5.63e-21 Prudent dietary pattern; CESC cis rs7666738 0.830 rs13136930 chr4:98937933 A/T cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs360798 0.512 rs2215870 chr2:63132342 C/G cg17519650 chr2:63277830 OTX1 0.52 6.58 0.37 2.55e-10 Coronary artery disease; CESC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.4 5.08 0.3 6.98e-7 Lymphocyte counts; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20021244 chr5:139944115 APBB3;SLC35A4 -0.47 -6.35 -0.36 9.13e-10 Gut microbiota (bacterial taxa); CESC cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.47 -6.11 -0.35 3.46e-9 Colorectal cancer; CESC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.34 -0.36 9.62e-10 Bipolar disorder; CESC cis rs1800469 1.000 rs2241714 chr19:41869392 C/T cg08477640 chr19:41863820 B9D2 -0.67 -9.4 -0.5 2.63e-18 Colorectal cancer; CESC cis rs2832077 0.527 rs11088095 chr21:30223188 A/T cg08807101 chr21:30365312 RNF160 -0.66 -8.57 -0.47 8.73e-16 Cognitive test performance; CESC cis rs2735413 0.881 rs12921945 chr16:78080133 G/T cg04733911 chr16:78082701 NA -0.53 -9.05 -0.49 3.11e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs4268898 0.636 rs76172309 chr2:24458911 G/C cg06627628 chr2:24431161 ITSN2 -0.98 -11.2 -0.57 4.39e-24 Asthma; CESC cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg10645314 chr2:3704589 ALLC -0.46 -5.09 -0.3 6.83e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs11785693 0.862 rs73183618 chr8:4988340 T/C cg26367366 chr8:4980734 NA 0.62 6.3 0.36 1.25e-9 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs524281 0.861 rs7935336 chr11:65865325 C/T cg14036092 chr11:66035641 RAB1B -0.62 -6.29 -0.36 1.27e-9 Electroencephalogram traits; CESC trans rs5756813 0.661 rs2285178 chr22:38205989 T/C cg19894588 chr14:64061835 NA -0.67 -8.32 -0.46 4.72e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs992157 0.560 rs6436047 chr2:219108913 A/C cg20019365 chr2:219134978 PNKD;AAMP 0.62 8.25 0.45 7.67e-15 Colorectal cancer; CESC cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg03060546 chr3:49711283 APEH 0.55 6.8 0.39 7.11e-11 Parkinson's disease; CESC cis rs637571 0.565 rs633800 chr11:65638719 G/A cg26695010 chr11:65641043 EFEMP2 0.61 7.75 0.43 1.99e-13 Eosinophil percentage of white cells; CESC cis rs35306767 0.953 rs7908138 chr10:962978 C/T cg26597838 chr10:835615 NA 0.82 9.53 0.51 1.07e-18 Eosinophil percentage of granulocytes; CESC cis rs4704187 0.663 rs28539749 chr5:74533902 G/A cg03227963 chr5:74354835 NA 0.27 5.04 0.3 8.67e-7 Response to amphetamines; CESC cis rs1707322 1.000 rs7531911 chr1:46330423 A/G cg03146154 chr1:46216737 IPP 0.74 10.16 0.53 1.08e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2727020 0.595 rs10466496 chr11:49501514 C/T cg15704280 chr7:45808275 SEPT13 -0.95 -16.98 -0.72 2.94e-44 Coronary artery disease; CESC cis rs4523957 0.891 rs216200 chr17:2199846 C/T cg16513277 chr17:2031491 SMG6 0.61 8.3 0.45 5.2e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1348850 0.958 rs1545364 chr2:178462882 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 8.95 0.48 6.21e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg03709012 chr19:19516395 GATAD2A 0.98 15.74 0.7 7.55e-40 Tonsillectomy; CESC trans rs73198271 0.710 rs7837843 chr8:8656485 A/G cg23754772 chr18:12253859 CIDEA -0.34 -6.26 -0.36 1.55e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2860975 0.620 rs7095531 chr10:96811841 A/G cg09036531 chr10:96991505 NA -0.36 -5.24 -0.31 3.25e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs2991971 0.716 rs7532573 chr1:45915892 A/T cg24296786 chr1:45957014 TESK2 -0.62 -8.77 -0.47 2.19e-16 High light scatter reticulocyte count; CESC cis rs9300255 0.739 rs1879380 chr12:123739111 G/A cg00376283 chr12:123451042 ABCB9 -0.62 -6.4 -0.37 6.86e-10 Neutrophil percentage of white cells; CESC cis rs7937682 0.855 rs539693 chr11:111477387 A/G cg22437258 chr11:111473054 SIK2 0.72 9.63 0.51 5.14e-19 Primary sclerosing cholangitis; CESC cis rs11122272 0.735 rs2808584 chr1:231512925 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs9814567 1.000 rs3846056 chr3:134227292 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.76 -0.33 2.38e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg11644478 chr21:40555479 PSMG1 -0.54 -7.36 -0.41 2.32e-12 Menarche (age at onset); CESC cis rs12887734 0.524 rs4900599 chr14:104283444 G/T cg08213375 chr14:104286397 PPP1R13B 0.41 6.91 0.39 3.66e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs56104184 0.775 rs17272700 chr19:49391770 G/A cg21252483 chr19:49399788 TULP2 -0.52 -5.65 -0.33 4.21e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg06634786 chr22:41940651 POLR3H -0.67 -6.55 -0.37 3.02e-10 Vitiligo; CESC cis rs17854409 0.803 rs1048100 chr20:61472073 C/A cg07645718 chr20:61493192 TCFL5 0.76 5.47 0.32 1.04e-7 Obesity-related traits; CESC cis rs3793683 0.597 rs12783367 chr10:134587334 T/C cg26818010 chr10:134567672 INPP5A -0.91 -11.2 -0.57 4.4e-24 Migraine; CESC cis rs6997458 0.813 rs3758078 chr8:86374664 A/G cg21346043 chr8:86351067 CA3 -0.34 -5.04 -0.3 8.56e-7 Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg23758822 chr17:41437982 NA 1.01 15.25 0.68 3.94e-38 Menopause (age at onset); CESC cis rs12765878 0.967 rs10883941 chr10:105650782 C/T cg11005552 chr10:105648138 OBFC1 0.34 5.05 0.3 8.35e-7 Coronary artery disease; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg10819733 chr22:24237672 NA -0.39 -5.57 -0.32 6.38e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.52 0.37 3.48e-10 Bipolar disorder; CESC cis rs2439831 0.681 rs526450 chr15:43599325 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.93 11.09 0.56 9.8e-24 Lung cancer in ever smokers; CESC cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC trans rs5756813 0.635 rs6000899 chr22:38203796 C/T cg19894588 chr14:64061835 NA -0.68 -8.42 -0.46 2.36e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs17601876 0.807 rs10519299 chr15:51551346 C/G cg19946085 chr15:51559439 CYP19A1 -0.34 -5.21 -0.3 3.85e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs4975616 0.869 rs466502 chr5:1325767 C/T cg26373071 chr5:1325741 CLPTM1L -0.41 -6.69 -0.38 1.3100000000000001e-10 Lung cancer; CESC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg07308232 chr7:1071921 C7orf50 -0.4 -5.47 -0.32 1.06e-7 Longevity;Endometriosis; CESC cis rs7084402 0.967 rs10826199 chr10:60274213 T/C cg07615347 chr10:60278583 BICC1 -0.57 -8.96 -0.48 6.01e-17 Refractive error; CESC cis rs9583531 0.527 rs3818496 chr13:111358488 G/A cg15841412 chr13:111365552 ING1 0.47 6.31 0.36 1.17e-9 Coronary artery disease; CESC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg02269571 chr22:50332266 NA -0.57 -7.1 -0.4 1.14e-11 Schizophrenia; CESC cis rs9522267 0.535 rs7339347 chr13:112237920 C/T cg10483660 chr13:112241077 NA -0.32 -5.74 -0.33 2.52e-8 Hepatitis; CESC cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.850 rs34033205 chr16:89922959 G/T cg04013166 chr16:89971882 TCF25 0.75 6.07 0.35 4.46e-9 Skin colour saturation; CESC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg06456125 chr7:65229604 NA 0.45 5.91 0.34 1.07e-8 Aortic root size; CESC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg04369109 chr6:150039330 LATS1 -0.41 -5.75 -0.33 2.42e-8 Lung cancer; CESC cis rs1008375 1.000 rs10939749 chr4:17692319 A/C cg16339924 chr4:17578868 LAP3 0.6 7.37 0.41 2.19e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg08859206 chr1:53392774 SCP2 0.54 7.13 0.4 9.6e-12 Monocyte count; CESC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg14403583 chr14:105418241 AHNAK2 -0.58 -8.07 -0.44 2.5e-14 Rheumatoid arthritis; CESC cis rs962856 0.866 rs13387185 chr2:67628649 G/T cg09028215 chr2:67624308 ETAA1 -0.39 -5.26 -0.31 2.9e-7 Pancreatic cancer; CESC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg00166722 chr3:10149974 C3orf24 0.45 5.38 0.31 1.68e-7 Alzheimer's disease; CESC cis rs1670533 1.000 rs34956924 chr4:1047270 T/C cg27284194 chr4:1044797 NA 0.47 5.74 0.33 2.62e-8 Recombination rate (females); CESC cis rs11792861 0.926 rs10512391 chr9:111809530 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 5.39 0.31 1.57e-7 Menarche (age at onset); CESC cis rs1577917 1.000 rs12663651 chr6:86701655 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.82 -0.34 1.67e-8 Response to antipsychotic treatment; CESC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg12373951 chr3:133503437 NA 0.43 6.3 0.36 1.24e-9 Iron status biomarkers; CESC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.38 0.31 1.6e-7 Major depressive disorder; CESC cis rs2239547 0.522 rs2581805 chr3:52979050 T/C cg11645453 chr3:52864694 ITIH4 -0.31 -5.22 -0.31 3.67e-7 Schizophrenia; CESC cis rs938554 0.736 rs4697699 chr4:9945722 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -6.01 -0.35 6.04e-9 Blood metabolite levels; CESC cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg06212747 chr3:49208901 KLHDC8B -0.67 -9.72 -0.51 2.75e-19 Menarche (age at onset); CESC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg25767906 chr1:53392781 SCP2 -0.47 -6.62 -0.38 1.97e-10 Monocyte count; CESC trans rs7251275 0.744 rs2270075 chr19:44132306 G/A cg12052658 chr17:14212064 HS3ST3B1 0.5 6.21 0.36 1.99e-9 Macrophage inflammatory protein 1b levels; CESC cis rs2304069 0.545 rs7445660 chr5:149413610 A/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.48 6.63 0.38 1.86e-10 HIV-1 control; CESC cis rs7953249 0.618 rs7954039 chr12:121398654 A/C cg02403541 chr12:121454288 C12orf43 -0.53 -6.9 -0.39 3.77e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg19717773 chr7:2847554 GNA12 -0.59 -8.53 -0.46 1.13e-15 Height; CESC cis rs6577655 0.517 rs4909294 chr8:135588020 C/T cg17885191 chr8:135476712 NA 0.46 5.17 0.3 4.61e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs9486719 1.000 rs11153064 chr6:97021959 A/G cg18709589 chr6:96969512 KIAA0776 -0.52 -5.7 -0.33 3.16e-8 Migraine;Coronary artery disease; CESC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg18904891 chr8:8559673 CLDN23 0.69 7.51 0.42 9.04e-13 Obesity-related traits; CESC cis rs9788333 0.707 rs12584557 chr13:21886171 C/A cg25811766 chr13:21894605 NA 0.79 11.97 0.59 1.1e-26 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22487624 chr1:115212681 DENND2C 0.51 6.19 0.36 2.34e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27629023 chr11:62648823 SLC3A2 0.56 6.5 0.37 4.01e-10 Gut microbiome composition (summer); CESC cis rs56775891 0.959 rs11663602 chr18:77578191 G/T cg24058013 chr18:77568902 NA -0.38 -5.34 -0.31 1.97e-7 Schizophrenia; CESC cis rs6502050 0.805 rs6502061 chr17:80086158 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.53 0.37 3.27e-10 Life satisfaction; CESC cis rs6088580 0.634 rs6088498 chr20:33020446 A/G cg08999081 chr20:33150536 PIGU 0.62 11.17 0.57 5.58e-24 Glomerular filtration rate (creatinine); CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg07157834 chr1:205819609 PM20D1 0.78 12.52 0.61 1.49e-28 Menarche (age at onset); CESC cis rs7582720 0.725 rs72934725 chr2:203725983 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7843479 0.601 rs2306645 chr8:21845428 C/T cg17168535 chr8:21777572 XPO7 -0.7 -10.71 -0.55 1.79e-22 Mean corpuscular volume; CESC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg27297192 chr10:134578999 INPP5A 0.4 5.27 0.31 2.77e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg05585544 chr11:47624801 NA -0.53 -8.07 -0.44 2.41e-14 Subjective well-being; CESC cis rs7692995 1.000 rs2125654 chr4:18025368 A/T cg08925142 chr4:18023851 LCORL -0.44 -5.21 -0.3 3.83e-7 Height; CESC cis rs3741151 1.000 rs79038783 chr11:73038746 C/G cg17517138 chr11:73019481 ARHGEF17 1.09 7.65 0.43 3.64e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs1950626 0.833 rs12897114 chr14:101395140 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.8 10.74 0.55 1.4e-22 Pelvic organ prolapse (moderate/severe); CESC cis rs2749592 0.611 rs176888 chr10:38406161 C/A cg00409905 chr10:38381863 ZNF37A -0.55 -7.03 -0.4 1.73e-11 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg08968635 chr6:28129556 ZNF389 0.41 5.28 0.31 2.68e-7 Depression; CESC cis rs3809863 0.602 rs11650072 chr17:45393665 A/G cg08085267 chr17:45401833 C17orf57 -0.69 -9.36 -0.5 3.48e-18 Glaucoma (primary open-angle); CESC cis rs4919694 1.000 rs12245343 chr10:104774050 A/G cg04362960 chr10:104952993 NT5C2 0.74 6.38 0.37 7.75e-10 Arsenic metabolism; CESC cis rs11864453 0.680 rs8047377 chr16:72148339 T/C cg01557791 chr16:72042693 DHODH -0.47 -6.34 -0.36 9.86e-10 Fibrinogen levels; CESC cis rs2046867 0.818 rs62249861 chr3:72867779 A/G cg25664220 chr3:72788482 NA -0.45 -6.52 -0.37 3.55e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs8044995 0.636 rs117761434 chr16:68254196 G/A cg26727032 chr16:67993705 SLC12A4 -0.48 -5.18 -0.3 4.5e-7 Schizophrenia; CESC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg04287289 chr16:89883240 FANCA -0.46 -5.83 -0.34 1.64e-8 Vitiligo; CESC cis rs4654899 0.931 rs4654887 chr1:21234923 A/G cg05370193 chr1:21551575 ECE1 -0.36 -5.34 -0.31 2e-7 Superior frontal gyrus grey matter volume; CESC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.27 0.36 1.46e-9 Bipolar disorder; CESC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg05776053 chr2:74358815 NA -0.4 -5.17 -0.3 4.69e-7 Gestational age at birth (maternal effect); CESC cis rs250677 0.687 rs10040624 chr5:148437579 A/G cg18129178 chr5:148520854 ABLIM3 -0.47 -5.3 -0.31 2.42e-7 Breast cancer; CESC cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.4 0.54 1.76e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.68 0.61 4e-29 Gut microbiome composition (summer); CESC cis rs910316 0.737 rs175499 chr14:75535927 G/A cg16144293 chr14:75469539 EIF2B2 0.4 5.27 0.31 2.83e-7 Height; CESC cis rs2353275 0.655 rs7068651 chr10:88160039 A/G cg07322936 chr10:88137208 NA 0.92 5.58 0.32 5.92e-8 Asthma (childhood onset);Asthma; CESC cis rs9888739 0.591 rs4632147 chr16:31363381 C/T cg15817542 chr16:31343056 ITGAM -0.49 -6.89 -0.39 4.17e-11 Systemic lupus erythematosus; CESC cis rs3812049 0.784 rs2568928 chr5:127487603 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.82 -10.2 -0.53 7.78e-21 Lymphocyte counts;Red cell distribution width; CESC cis rs4808199 0.895 rs7252888 chr19:19628037 C/T cg03709012 chr19:19516395 GATAD2A 1.04 12.86 0.62 9.68e-30 Nonalcoholic fatty liver disease; CESC cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg19077165 chr18:44547161 KATNAL2 0.65 9.86 0.52 9.48e-20 Personality dimensions; CESC cis rs35955747 0.869 rs5997909 chr22:31591228 G/A cg25791279 chr22:32026902 PISD -0.45 -5.36 -0.31 1.81e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg07153921 chr17:41440717 NA -0.38 -5.03 -0.3 9.22e-7 Menopause (age at onset); CESC cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg15485101 chr11:133734466 NA 0.4 6.56 0.37 2.88e-10 Childhood ear infection; CESC cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.86 0.48 1.22e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.676 rs1829694 chr6:109593860 G/T cg01475377 chr6:109611718 NA -0.44 -6.99 -0.39 2.19e-11 Reticulocyte fraction of red cells; CESC cis rs910316 1.000 rs7156328 chr14:75532941 T/C cg11812906 chr14:75593930 NEK9 0.89 15.17 0.68 7.72e-38 Height; CESC trans rs7849782 0.935 rs2485534 chr9:104451338 A/T cg09047884 chr22:43484984 TTLL1 -0.44 -6.07 -0.35 4.3e-9 Coronary artery aneurysm in Kawasaki disease; CESC cis rs73110464 0.609 rs727266 chr12:53356411 C/T cg14581129 chr12:53358946 NA -0.57 -7.87 -0.44 9.29e-14 Cancer (pleiotropy); CESC cis rs11792861 0.781 rs17729408 chr9:111740860 A/G cg05043794 chr9:111880884 C9orf5 0.4 6.55 0.37 3.06e-10 Menarche (age at onset); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg03574882 chr7:151574332 PRKAG2 0.43 6.0 0.35 6.51e-9 Breast cancer;Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09149896 chr17:48624438 SPATA20 -0.4 -6.11 -0.35 3.52e-9 Gambling; CESC cis rs62064224 0.589 rs8069673 chr17:30661250 C/T cg18200150 chr17:30822561 MYO1D -0.39 -5.12 -0.3 5.97e-7 Schizophrenia; CESC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg18876405 chr7:65276391 NA -0.53 -7.38 -0.41 2.09e-12 Aortic root size; CESC cis rs2404602 0.684 rs62026898 chr15:76944371 C/A cg23625390 chr15:77176239 SCAPER -0.45 -6.21 -0.36 2.04e-9 Blood metabolite levels; CESC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.67 0.64 1.54e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11204677 1 rs11204677 chr1:150574695 C/G cg18016565 chr1:150552671 MCL1 -0.42 -6.89 -0.39 4.03e-11 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs1355223 0.506 rs1509660 chr11:34865017 A/G cg11058730 chr11:34937778 PDHX;APIP -0.54 -6.72 -0.38 1.12e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19429466 chr4:87515395 PTPN13 -0.48 -6.3 -0.36 1.23e-9 Ulcerative colitis; CESC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.4 0.57 9.22e-25 Alzheimer's disease; CESC cis rs910316 1.000 rs175443 chr14:75601963 C/T cg16144293 chr14:75469539 EIF2B2 0.38 5.03 0.3 9.15e-7 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12393716 chr11:62495049 TTC9C;HNRNPUL2 0.49 6.49 0.37 4.25e-10 Gut microbiota (bacterial taxa); CESC cis rs9549367 0.789 rs9549708 chr13:113891887 A/G cg00898013 chr13:113819073 PROZ -0.51 -6.95 -0.39 2.78e-11 Platelet distribution width; CESC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg08736216 chr1:53307985 ZYG11A -0.42 -7.0 -0.4 2.05e-11 Monocyte count; CESC cis rs7793919 0.726 rs10232008 chr7:4783206 T/G cg09789173 chr7:4769017 FOXK1 0.76 11.45 0.58 6.14e-25 Mosquito bite size; CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg15147215 chr3:52552868 STAB1 0.29 5.11 0.3 6.3e-7 Electroencephalogram traits; CESC cis rs4704187 0.687 rs2335136 chr5:74407994 T/C cg03227963 chr5:74354835 NA 0.32 5.94 0.34 8.7e-9 Response to amphetamines; CESC cis rs2479724 0.935 rs1887718 chr6:41857691 C/T cg08135965 chr6:41755394 TOMM6 0.43 5.98 0.34 7.34e-9 Menarche (age at onset); CESC cis rs7086627 0.515 rs1870147 chr10:82212541 A/T cg03267442 chr10:82210566 NA -0.32 -5.14 -0.3 5.28e-7 Post bronchodilator FEV1; CESC cis rs28595532 0.800 rs67686161 chr4:119336720 C/T cg21605333 chr4:119757512 SEC24D 0.93 5.92 0.34 1.02e-8 Cannabis dependence symptom count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12754671 chr1:161171876 NDUFS2 0.57 6.64 0.38 1.78e-10 Gut microbiome composition (summer); CESC cis rs6088580 0.543 rs13042351 chr20:33238573 G/A cg24642439 chr20:33292090 TP53INP2 -0.45 -5.29 -0.31 2.6e-7 Glomerular filtration rate (creatinine); CESC cis rs3741151 0.686 rs12288753 chr11:73136261 A/T cg17517138 chr11:73019481 ARHGEF17 0.64 5.5 0.32 8.83e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs8114671 0.562 rs6120739 chr20:33405227 A/G cg24642439 chr20:33292090 TP53INP2 0.43 5.18 0.3 4.31e-7 Height; CESC cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg00033643 chr7:134001901 SLC35B4 0.41 5.17 0.3 4.67e-7 Mean platelet volume; CESC cis rs7017914 0.967 rs35207116 chr8:71708971 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.43 -5.5 -0.32 8.84e-8 Bone mineral density; CESC cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg05472934 chr7:22766657 IL6 0.86 11.55 0.58 2.89e-25 Lung cancer; CESC cis rs17039065 1.000 rs719786 chr4:109396732 G/A cg16022748 chr4:109541635 LOC285456;RPL34 0.61 5.16 0.3 4.75e-7 Gut microbiome composition (summer); CESC cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg24110177 chr3:50126178 RBM5 0.52 7.16 0.4 7.81e-12 Intelligence (multi-trait analysis); CESC cis rs11792861 0.926 rs1044905 chr9:111781495 G/A cg05043794 chr9:111880884 C9orf5 -0.41 -6.82 -0.39 6.13e-11 Menarche (age at onset); CESC cis rs7296418 0.675 rs1879379 chr12:123727443 G/A cg00376283 chr12:123451042 ABCB9 0.63 8.74 0.47 2.77e-16 Platelet count; CESC cis rs75477785 0.590 rs12078802 chr1:210143601 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.91 6.32 0.36 1.09e-9 Cleft lip with or without cleft palate; CESC cis rs7264396 0.563 rs2425121 chr20:34326186 A/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.86 0.39 4.77e-11 Total cholesterol levels; CESC cis rs10129255 0.957 rs8014696 chr14:107177994 A/C cg23076370 chr14:107095027 NA 0.43 5.48 0.32 1.01e-7 Kawasaki disease; CESC cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg15782153 chr7:917662 C7orf20 0.49 7.01 0.4 1.95e-11 Perceived unattractiveness to mosquitoes; CESC cis rs71277158 0.688 rs73879173 chr3:169845604 T/G cg04067573 chr3:169899625 PHC3 0.71 7.11 0.4 1.06e-11 Prostate cancer; CESC cis rs11098499 0.954 rs10008459 chr4:120394231 T/C cg24375607 chr4:120327624 NA 0.45 5.74 0.33 2.61e-8 Corneal astigmatism; CESC cis rs4132509 0.895 rs12138168 chr1:244009113 A/G cg21452805 chr1:244014465 NA 0.53 6.41 0.37 6.49e-10 RR interval (heart rate); CESC trans rs1814175 0.591 rs11040589 chr11:49862449 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.51e-9 Height; CESC cis rs4700695 0.719 rs27077 chr5:65445342 C/T cg21114390 chr5:65439923 SFRS12 0.45 5.58 0.32 6.01e-8 Facial morphology (factor 19); CESC cis rs7084402 0.967 rs1649092 chr10:60289389 A/T cg07615347 chr10:60278583 BICC1 0.63 10.13 0.53 1.3e-20 Refractive error; CESC cis rs722599 0.748 rs731165 chr14:75352555 T/C cg11812906 chr14:75593930 NEK9 -0.47 -5.68 -0.33 3.49e-8 IgG glycosylation; CESC cis rs7208859 0.623 rs9895785 chr17:29107708 C/T cg13385521 chr17:29058706 SUZ12P -0.79 -6.36 -0.36 8.73e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs67311347 0.866 rs1454491 chr3:40352647 C/G cg09455208 chr3:40491958 NA 0.41 6.93 0.39 3.2e-11 Renal cell carcinoma; CESC cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.43 5.76 0.33 2.27e-8 Tonsillectomy; CESC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.68 9.48 0.5 1.49e-18 Menopause (age at onset); CESC cis rs9858542 0.953 rs9859556 chr3:49455986 G/T cg03060546 chr3:49711283 APEH -0.53 -6.01 -0.35 6.14e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7605827 0.860 rs6760297 chr2:15632472 T/C cg19274914 chr2:15703543 NA 0.36 6.42 0.37 6.32e-10 Educational attainment (years of education); CESC cis rs2180341 0.782 rs6924274 chr6:127721556 T/A cg24812749 chr6:127587940 RNF146 0.82 11.71 0.58 8.13e-26 Breast cancer; CESC cis rs7809950 1.000 rs2712191 chr7:107182724 C/G cg23024343 chr7:107201750 COG5 -0.41 -5.78 -0.33 2.1e-8 Coronary artery disease; CESC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg23758822 chr17:41437982 NA 1.04 15.64 0.69 1.61e-39 Menopause (age at onset); CESC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg25036284 chr2:26402008 FAM59B 0.84 8.75 0.47 2.61e-16 Gut microbiome composition (summer); CESC cis rs7945705 0.967 rs10769970 chr11:8917937 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.37 5.95 0.34 8.38e-9 Hemoglobin concentration; CESC cis rs7927592 0.731 rs11228288 chr11:68353550 A/G cg20283391 chr11:68216788 NA -0.42 -5.16 -0.3 4.82e-7 Total body bone mineral density; CESC cis rs7659604 1.000 rs35249024 chr4:122664538 C/A cg19671926 chr4:122722719 EXOSC9 -0.45 -5.26 -0.31 2.96e-7 Type 2 diabetes; CESC cis rs1949733 0.701 rs2631735 chr4:8476118 A/G cg11789530 chr4:8429930 ACOX3 0.67 7.63 0.42 4.17e-13 Response to antineoplastic agents; CESC trans rs208520 0.690 rs207077 chr6:66769855 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -12.03 -0.59 6.99e-27 Exhaled nitric oxide output; CESC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.01 0.56 1.86e-23 Alzheimer's disease; CESC cis rs9611565 0.559 rs1006407 chr22:41972032 T/C cg17376030 chr22:41985996 PMM1 0.78 7.98 0.44 4.51e-14 Vitiligo; CESC cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg24110177 chr3:50126178 RBM5 0.59 8.32 0.45 4.85e-15 Body mass index; CESC cis rs7829975 0.714 rs4840362 chr8:8670082 C/G cg15556689 chr8:8085844 FLJ10661 -0.43 -5.57 -0.32 6.36e-8 Mood instability; CESC cis rs561341 0.941 rs2428341 chr17:30317295 C/T cg00745463 chr17:30367425 LRRC37B -0.48 -5.29 -0.31 2.55e-7 Hip circumference adjusted for BMI; CESC cis rs12541635 0.966 rs2029881 chr8:107002226 A/G cg10147462 chr8:107024639 NA 0.4 5.69 0.33 3.32e-8 Age of smoking initiation; CESC cis rs9287719 0.967 rs728281 chr2:10750355 T/C cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs5769765 1.000 rs764813 chr22:50286172 T/C cg26441486 chr22:50317300 CRELD2 0.38 5.37 0.31 1.77e-7 Schizophrenia; CESC cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg15017067 chr4:17643749 FAM184B 0.34 5.05 0.3 8.24e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12136530 0.593 rs9287047 chr1:19736534 T/C cg01832549 chr1:19774989 CAPZB -0.44 -6.23 -0.36 1.85e-9 Lead levels in blood; CESC cis rs6963495 0.745 rs818620 chr7:105172685 G/C cg19920283 chr7:105172520 RINT1 0.71 7.92 0.44 6.76e-14 Bipolar disorder (body mass index interaction); CESC cis rs9287719 0.934 rs6432111 chr2:10744620 A/C cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg17427002 chr7:12443146 VWDE -0.53 -5.31 -0.31 2.38e-7 Coronary artery disease; CESC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg22823121 chr1:150693482 HORMAD1 0.4 5.7 0.33 3.2e-8 Melanoma; CESC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg11764359 chr7:65958608 NA 0.81 9.9 0.52 7.51e-20 Aortic root size; CESC cis rs989128 0.600 rs739924 chr17:48631607 T/C cg24438145 chr17:48624694 SPATA20 0.44 5.17 0.3 4.57e-7 Type 2 diabetes; CESC cis rs727563 0.555 rs5751136 chr22:42075581 T/A cg06481639 chr22:41940642 POLR3H 0.5 5.3 0.31 2.49e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs10463316 0.823 rs7700342 chr5:150776323 C/T cg03212797 chr5:150827313 SLC36A1 -0.51 -6.81 -0.39 6.65e-11 Metabolite levels (Pyroglutamine); CESC cis rs9488822 0.636 rs12201275 chr6:116314563 C/G cg15226275 chr6:116381976 FRK 0.25 6.24 0.36 1.72e-9 Cholesterol, total;LDL cholesterol; CESC cis rs6543140 0.964 rs2160200 chr2:103033963 G/T cg04239558 chr2:103089729 SLC9A4 0.45 5.76 0.33 2.28e-8 Blood protein levels; CESC cis rs1847202 0.859 rs4274693 chr3:72949375 A/G cg25664220 chr3:72788482 NA -0.37 -5.68 -0.33 3.51e-8 Motion sickness; CESC cis rs1448094 0.549 rs4919770 chr12:86238050 G/T cg19622623 chr12:86230825 RASSF9 -0.41 -5.04 -0.3 8.46e-7 Major depressive disorder; CESC cis rs6545883 0.931 rs12713437 chr2:61722904 C/T cg15711740 chr2:61764176 XPO1 -0.42 -5.32 -0.31 2.25e-7 Tuberculosis; CESC cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg25019033 chr10:957182 NA -0.6 -6.41 -0.37 6.76e-10 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09301086 chr2:3691534 COLEC11 -0.54 -6.47 -0.37 4.82e-10 Gut microbiome composition (summer); CESC cis rs67311347 0.577 rs2887951 chr3:40282104 C/G cg09455208 chr3:40491958 NA 0.35 5.62 0.33 4.82e-8 Renal cell carcinoma; CESC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg16325326 chr1:53192061 ZYG11B 0.73 11.05 0.56 1.33e-23 Monocyte count; CESC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.87 0.44 9.16e-14 Menopause (age at onset); CESC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg26335602 chr6:28129616 ZNF389 0.48 6.54 0.37 3.07e-10 Depression; CESC cis rs12681288 0.963 rs7822955 chr8:1029090 C/T cg04851639 chr8:1020857 NA 0.34 7.17 0.4 7.35e-12 Schizophrenia; CESC cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg14345882 chr6:26364793 BTN3A2 0.42 5.3 0.31 2.41e-7 Intelligence (multi-trait analysis); CESC cis rs11190604 1.000 rs75063298 chr10:102213600 C/A cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7520050 0.966 rs12564541 chr1:46380237 G/A cg03146154 chr1:46216737 IPP -0.48 -6.21 -0.36 2.08e-9 Red blood cell count;Reticulocyte count; CESC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg12419862 chr22:24373484 LOC391322 -0.73 -10.26 -0.53 5.15e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs16867579 1.000 rs16867579 chr8:102375267 A/C cg17311587 chr7:1250088 NA 0.62 6.08 0.35 4.08e-9 Smooth-surface caries; CESC trans rs208520 0.690 rs12198745 chr6:66722598 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.51 0.58 3.9e-25 Exhaled nitric oxide output; CESC cis rs7188697 0.922 rs11862156 chr16:58596753 C/T cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.64 0.38 1.73e-10 Bipolar disorder; CESC trans rs5763662 0.661 rs12484740 chr22:30606927 C/T cg03005062 chr1:38680057 NA -0.69 -6.01 -0.35 5.97e-9 LDL cholesterol levels;LDL cholesterol; CESC cis rs11190604 1.000 rs10786597 chr10:102291287 C/T cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs7561273 0.586 rs4149372 chr2:24305512 T/G cg01493198 chr2:24299560 SF3B14 0.41 5.07 0.3 7.53e-7 Quantitative traits; CESC cis rs12586317 0.547 rs115019197 chr14:35503764 G/A cg05294307 chr14:35346193 BAZ1A -0.51 -5.4 -0.31 1.49e-7 Psoriasis; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg00635299 chr1:220219163 EPRS 0.42 6.39 0.37 7.31e-10 Positive affect; CESC cis rs3820068 0.581 rs72645879 chr1:15928199 A/G cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs2734839 0.537 rs1554929 chr11:113278764 C/T cg14159747 chr11:113255604 NA 0.37 6.75 0.38 9.24e-11 Information processing speed; CESC cis rs2439831 0.850 rs12440573 chr15:44108997 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.66 5.97 0.34 7.71e-9 Lung cancer in ever smokers; CESC cis rs7666738 0.546 rs62320963 chr4:98839297 A/G cg17366294 chr4:99064904 C4orf37 0.5 6.03 0.35 5.49e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6732160 0.588 rs13394018 chr2:73372605 C/T cg01422370 chr2:73384389 NA 0.56 9.17 0.49 1.38e-17 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09352908 chr3:37017749 NA 0.49 6.87 0.39 4.44e-11 Fibrinogen levels; CESC cis rs2415984 0.562 rs1389605 chr14:46964784 T/C cg14871534 chr14:47121158 RPL10L 0.39 5.49 0.32 9.54e-8 Number of children ever born; CESC cis rs7786808 0.741 rs7789415 chr7:158227617 C/T cg09998033 chr7:158218633 PTPRN2 -0.38 -5.66 -0.33 3.87e-8 Obesity-related traits; CESC cis rs734999 0.545 rs6666430 chr1:2698950 G/A cg18854424 chr1:2615690 NA 0.3 5.75 0.33 2.44e-8 Ulcerative colitis; CESC cis rs3540 0.576 rs10152871 chr15:91047469 G/A cg10434728 chr15:90938212 IQGAP1 -0.43 -7.77 -0.43 1.72e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9314323 0.964 rs3808579 chr8:26250682 C/T cg11498726 chr8:26250323 BNIP3L -0.45 -6.62 -0.38 2.02e-10 Red cell distribution width; CESC cis rs9660992 0.674 rs1151785 chr1:205232299 C/T cg00857998 chr1:205179979 DSTYK 0.47 5.35 0.31 1.87e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.51 0.46 1.33e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg20243544 chr17:37824526 PNMT -0.44 -5.29 -0.31 2.51e-7 Glomerular filtration rate (creatinine); CESC cis rs4911259 0.513 rs6057665 chr20:31463460 A/G cg13636640 chr20:31349939 DNMT3B -0.53 -7.41 -0.41 1.66e-12 Inflammatory bowel disease; CESC cis rs11203032 0.831 rs12219735 chr10:90922890 C/T cg16672925 chr10:90967113 CH25H 0.74 7.05 0.4 1.56e-11 Heart failure; CESC cis rs7649275 0.938 rs1809282 chr3:53781957 A/G cg21503701 chr3:53781065 CACNA1D -0.38 -5.11 -0.3 6.12e-7 Trans fatty acid levels; CESC cis rs6570726 0.791 rs422099 chr6:145806936 C/T cg05347473 chr6:146136440 FBXO30 0.57 7.33 0.41 2.79e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1045714 0.895 rs61729413 chr7:2646796 G/A cg20813462 chr7:2646259 IQCE 0.63 5.44 0.32 1.19e-7 Urate levels in lean individuals; CESC cis rs13006833 0.634 rs1876877 chr2:191145274 G/A cg25963032 chr2:191064776 C2orf88 0.37 5.05 0.3 8.21e-7 Urinary metabolites; CESC cis rs9937943 0.667 rs12934000 chr16:74623420 T/G cg01733217 chr16:74700730 RFWD3 0.58 5.27 0.31 2.79e-7 Neutrophil percentage of white cells; CESC cis rs910316 1.000 rs13099 chr14:75599155 G/A cg16144293 chr14:75469539 EIF2B2 0.4 5.25 0.31 3.14e-7 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24908708 chr8:95835570 INTS8 -0.44 -6.15 -0.35 2.79e-9 Fibrinogen levels; CESC cis rs7100689 0.577 rs1143694 chr10:82040052 C/T cg00277334 chr10:82204260 NA 0.51 6.59 0.38 2.41e-10 Post bronchodilator FEV1; CESC cis rs909002 0.759 rs10914454 chr1:32078940 G/A cg13919466 chr1:32135498 COL16A1 -0.47 -8.4 -0.46 2.72e-15 Intelligence (multi-trait analysis); CESC cis rs12155623 0.803 rs7011862 chr8:49817333 C/G cg00325661 chr8:49890786 NA 0.39 5.22 0.31 3.63e-7 Sudden cardiac arrest; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19188060 chr3:184017239 PSMD2 -0.47 -6.41 -0.37 6.57e-10 Fibrinogen levels; CESC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg18230493 chr5:56204884 C5orf35 -0.73 -8.57 -0.47 8.93e-16 Initial pursuit acceleration; CESC cis rs4076764 0.914 rs10753614 chr1:163365903 C/T cg06092702 chr1:163392909 NA 0.43 6.27 0.36 1.48e-9 Motion sickness; CESC cis rs7264396 0.563 rs73902913 chr20:34432784 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -9.34 -0.5 4.01e-18 Total cholesterol levels; CESC cis rs3741404 0.609 rs687581 chr11:63871533 G/T cg18225595 chr11:63971243 STIP1 -0.52 -6.8 -0.39 7.07e-11 Platelet count; CESC cis rs2204008 0.701 rs3898237 chr12:38219714 A/G cg13010199 chr12:38710504 ALG10B 0.53 6.65 0.38 1.69e-10 Bladder cancer; CESC cis rs7208859 0.673 rs9915963 chr17:29019643 C/T cg19761014 chr17:28927070 LRRC37B2 0.67 5.99 0.35 6.81e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg23158103 chr7:148848205 ZNF398 -0.4 -6.4 -0.37 7.03e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7714584 1.000 rs7709650 chr5:150246685 C/T cg22134413 chr5:150180641 NA 0.55 6.08 0.35 4.25e-9 Crohn's disease; CESC cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.69 9.01 0.48 4.25e-17 Age-related macular degeneration (geographic atrophy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17021988 chr4:40428050 RBM47 -0.62 -7.46 -0.42 1.24e-12 Gut microbiome composition (summer); CESC cis rs4642101 0.824 rs11717013 chr3:12843862 A/C cg05775895 chr3:12838266 CAND2 0.39 5.78 0.33 2.1e-8 QRS complex (12-leadsum); CESC cis rs9457247 0.663 rs7749278 chr6:167435325 C/T cg25258033 chr6:167368657 RNASET2 -0.35 -5.05 -0.3 8.36e-7 Crohn's disease; CESC cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg18357645 chr12:58087776 OS9 -0.41 -5.77 -0.33 2.24e-8 Multiple sclerosis; CESC cis rs295140 0.605 rs34693942 chr2:201184348 T/C cg23649088 chr2:200775458 C2orf69 -0.43 -5.73 -0.33 2.79e-8 QT interval; CESC trans rs7819412 0.522 rs10088853 chr8:10987967 G/A cg11875060 chr3:155571743 SLC33A1 -0.51 -6.19 -0.36 2.24e-9 Triglycerides; CESC cis rs7044106 0.762 rs1470307 chr9:123433039 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.72 10.68 0.55 2.28e-22 Hip circumference adjusted for BMI; CESC cis rs11997175 0.600 rs4739590 chr8:33802686 A/G ch.8.33884649F chr8:33765107 NA 0.55 7.21 0.4 5.86e-12 Body mass index; CESC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg00750074 chr16:89608354 SPG7 -0.41 -5.97 -0.34 7.57e-9 Multiple myeloma (IgH translocation); CESC cis rs7267979 1.000 rs6083862 chr20:25411086 A/T cg08601574 chr20:25228251 PYGB -0.34 -5.23 -0.31 3.5e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2522056 0.935 rs1981524 chr5:131756506 C/T cg24060327 chr5:131705240 SLC22A5 0.68 7.78 0.43 1.66e-13 Lymphocyte counts;Fibrinogen; CESC cis rs1050631 0.592 rs1785927 chr18:33726447 C/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.53 7.16 0.4 7.87e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg01579765 chr21:45077557 HSF2BP -0.54 -8.9 -0.48 8.97e-17 Mean corpuscular volume; CESC cis rs11098499 0.697 rs11941899 chr4:120382758 C/A cg09307838 chr4:120376055 NA 0.95 13.79 0.65 5.71e-33 Corneal astigmatism; CESC trans rs8073060 0.544 rs8072676 chr17:33999517 C/T cg19694781 chr19:47549865 TMEM160 -0.72 -6.84 -0.39 5.32e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs6752107 1.000 rs6738490 chr2:234161583 T/C cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.38 5.85 0.34 1.45e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs748404 0.660 rs2439845 chr15:43722610 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.3 0.45 5.47e-15 Lung cancer; CESC cis rs826838 0.967 rs4768329 chr12:39129394 T/C cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs8060686 0.641 rs55725810 chr16:68189636 C/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.02 -0.35 5.67e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs2463822 0.920 rs7924998 chr11:62073980 C/G cg06239285 chr11:62104954 ASRGL1 -1.13 -9.93 -0.52 5.78e-20 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs3540 0.512 rs7176518 chr15:91079637 C/T cg22089800 chr15:90895588 ZNF774 -0.62 -8.44 -0.46 2.05e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs7927771 0.524 rs10838769 chr11:47825333 A/G cg20307385 chr11:47447363 PSMC3 -0.58 -8.03 -0.44 3.12e-14 Subjective well-being; CESC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg17724175 chr1:150552817 MCL1 0.41 6.26 0.36 1.55e-9 Melanoma; CESC cis rs12541635 0.677 rs61002083 chr8:106982132 A/G cg10147462 chr8:107024639 NA 0.45 6.53 0.37 3.37e-10 Age of smoking initiation; CESC cis rs4727027 0.933 rs757738 chr7:148872351 T/G cg23158103 chr7:148848205 ZNF398 -0.42 -6.8 -0.39 6.87e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.64e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs5753618 0.583 rs5749279 chr22:31854209 A/G cg13145458 chr22:31556086 RNF185 -0.43 -5.34 -0.31 2.01e-7 Colorectal cancer; CESC cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.42 0.32 1.34e-7 Tonsillectomy; CESC trans rs6700559 0.810 rs2808250 chr1:200592547 A/T cg13401811 chr12:52345646 ACVR1B 0.47 6.03 0.35 5.59e-9 Coronary artery disease; CESC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg20243544 chr17:37824526 PNMT 0.48 6.04 0.35 5.29e-9 Glomerular filtration rate (creatinine); CESC cis rs3791406 0.654 rs3752804 chr2:240029490 C/T cg13090969 chr2:240043331 HDAC4 -0.52 -6.29 -0.36 1.29e-9 Skin aging (microtopography measurement); CESC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg18758796 chr5:131593413 PDLIM4 -0.43 -5.96 -0.34 8.15e-9 Blood metabolite levels; CESC cis rs1538970 0.924 rs11211118 chr1:45930270 A/C cg05343316 chr1:45956843 TESK2 0.89 12.12 0.6 3.27e-27 Platelet count; CESC cis rs2952156 0.834 rs903503 chr17:37829571 C/A cg20243544 chr17:37824526 PNMT 0.63 8.15 0.45 1.47e-14 Asthma; CESC cis rs11229555 0.645 rs34794607 chr11:58188401 A/T cg15696309 chr11:58395628 NA -0.42 -5.05 -0.3 8.13e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs10752881 0.875 rs10797825 chr1:183024581 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.5 0.64 5.97e-32 Colorectal cancer; CESC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg27535305 chr1:53392650 SCP2 -0.33 -5.38 -0.31 1.66e-7 Monocyte count; CESC cis rs2120019 0.938 rs8040169 chr15:75370958 C/A cg17294928 chr15:75287854 SCAMP5 -0.59 -6.65 -0.38 1.64e-10 Blood trace element (Zn levels); CESC cis rs67311347 1.000 rs73078164 chr3:40480289 G/A cg09455208 chr3:40491958 NA 0.49 8.07 0.44 2.53e-14 Renal cell carcinoma; CESC trans rs2727020 0.894 rs1880438 chr11:49370698 A/G cg15704280 chr7:45808275 SEPT13 -0.76 -9.47 -0.5 1.61e-18 Coronary artery disease; CESC cis rs12142240 0.698 rs6684274 chr1:46810842 A/G cg10495392 chr1:46806563 NSUN4 -0.57 -6.28 -0.36 1.38e-9 Menopause (age at onset); CESC cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg20503657 chr10:835505 NA 0.78 7.74 0.43 2.08e-13 Eosinophil percentage of granulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21864845 chr1:1208426 UBE2J2 0.46 6.11 0.35 3.5e-9 Gut microbiota (bacterial taxa); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07421368 chr2:67624930 ETAA1 0.47 6.01 0.35 6.2e-9 Gut microbiota (bacterial taxa); CESC cis rs2997447 0.655 rs2275949 chr1:26385150 C/G cg19633962 chr1:26362018 EXTL1 -0.55 -5.5 -0.32 9.06e-8 QRS complex (12-leadsum); CESC trans rs1973993 0.967 rs6679458 chr1:96946253 G/T cg10631902 chr5:14652156 NA 0.46 6.22 0.36 1.95e-9 Weight; CESC cis rs7116495 0.609 rs674319 chr11:71775391 T/C cg07596299 chr11:71824057 C11orf51 -0.93 -5.87 -0.34 1.32e-8 Severe influenza A (H1N1) infection; CESC cis rs13191362 0.507 rs2849518 chr6:163134248 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.55 -6.43 -0.37 5.93e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2204008 0.818 rs1589389 chr12:38416041 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.4 -0.31 1.49e-7 Bladder cancer; CESC cis rs244293 0.965 rs244287 chr17:53232036 C/T cg19360675 chr17:53046073 COX11;STXBP4 0.39 5.09 0.3 6.7e-7 Menarche (age at onset); CESC cis rs10129255 0.556 rs6576222 chr14:107184681 G/A cg23076370 chr14:107095027 NA -0.65 -9.81 -0.52 1.35e-19 Kawasaki disease; CESC cis rs8077889 0.750 rs80053172 chr17:41936843 C/T cg26893861 chr17:41843967 DUSP3 0.86 8.51 0.46 1.31e-15 Triglycerides; CESC cis rs732765 0.602 rs2359192 chr14:75410523 A/C cg21190982 chr14:75180524 FCF1;KIAA0317 0.36 5.17 0.3 4.6e-7 Non-small cell lung cancer; CESC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg12463550 chr7:65579703 CRCP 0.59 7.56 0.42 6.49e-13 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09235050 chr20:57599210 TUBB1 -0.59 -7.11 -0.4 1.07e-11 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg05368731 chr17:41323189 NBR1 -0.55 -7.52 -0.42 8.38e-13 Menopause (age at onset); CESC cis rs4888262 0.514 rs8048239 chr16:74578317 A/T cg01733217 chr16:74700730 RFWD3 0.82 11.54 0.58 3.04e-25 Testicular germ cell tumor; CESC cis rs1707322 1.000 rs10890372 chr1:46391020 T/G cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg04455712 chr21:45112962 RRP1B -0.39 -5.75 -0.33 2.48e-8 Mean corpuscular volume; CESC cis rs9549367 0.789 rs35569628 chr13:113872712 T/C cg00898013 chr13:113819073 PROZ -0.5 -7.29 -0.41 3.65e-12 Platelet distribution width; CESC cis rs9894429 0.646 rs7405870 chr17:79617284 G/A cg18240062 chr17:79603768 NPLOC4 0.51 6.58 0.37 2.48e-10 Eye color traits; CESC cis rs55788414 0.527 rs2873368 chr16:81184208 C/G cg06400318 chr16:81190750 PKD1L2 -0.6 -6.77 -0.38 8.45e-11 Left ventricular obstructive tract defect (maternal effect); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18543035 chr10:8374526 NA 0.44 6.12 0.35 3.28e-9 Systemic lupus erythematosus; CESC cis rs16854884 0.657 rs35788195 chr3:143739311 C/T cg06585982 chr3:143692056 C3orf58 0.49 6.14 0.35 2.96e-9 Economic and political preferences (feminism/equality); CESC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs67311347 1.000 rs1123019 chr3:40488280 C/T cg24209194 chr3:40518798 ZNF619 0.5 6.26 0.36 1.54e-9 Renal cell carcinoma; CESC cis rs7408868 1.000 rs10410514 chr19:15277610 C/T cg14696996 chr19:15285081 NOTCH3 1.11 11.94 0.59 1.43e-26 Pulse pressure; CESC cis rs60154123 0.505 rs7540237 chr1:210053325 C/T cg21951975 chr1:209979733 IRF6 0.59 6.43 0.37 5.96e-10 Coronary artery disease; CESC cis rs6815814 0.768 rs6835514 chr4:38894380 C/T cg02016764 chr4:38805732 TLR1 0.42 6.19 0.36 2.31e-9 Breast cancer; CESC cis rs9894429 0.546 rs55917554 chr17:79608776 T/C cg18240062 chr17:79603768 NPLOC4 0.67 8.9 0.48 8.9e-17 Eye color traits; CESC cis rs909002 0.849 rs7546297 chr1:32106494 A/G cg13919466 chr1:32135498 COL16A1 -0.48 -8.27 -0.45 6.34e-15 Intelligence (multi-trait analysis); CESC cis rs17376456 0.877 rs28633397 chr5:93447048 A/G cg25358565 chr5:93447407 FAM172A 1.15 11.8 0.59 4.11e-26 Diabetic retinopathy; CESC cis rs9596863 1.000 rs9596866 chr13:54459385 A/T ch.13.53330881F chr13:54432880 NA 0.65 5.22 0.31 3.58e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs4889855 0.614 rs7221663 chr17:78484166 T/C cg00066239 chr17:78472159 NA -0.38 -5.22 -0.31 3.55e-7 Fractional excretion of uric acid; CESC cis rs8114671 0.551 rs4911162 chr20:33411425 G/C cg06115741 chr20:33292138 TP53INP2 0.49 5.81 0.34 1.76e-8 Height; CESC cis rs2932538 0.961 rs12126494 chr1:113228623 G/A cg22162597 chr1:113214053 CAPZA1 0.6 7.25 0.41 4.6e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.44 -5.47 -0.32 1.05e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs35955747 0.869 rs28715 chr22:31730169 C/T cg25791279 chr22:32026902 PISD 0.5 6.05 0.35 4.98e-9 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg17971929 chr21:40555470 PSMG1 1.08 16.28 0.71 9.03e-42 Cognitive function; CESC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg09699651 chr6:150184138 LRP11 0.4 5.1 0.3 6.34e-7 Lung cancer; CESC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.23 -0.36 1.86e-9 Schizophrenia; CESC cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg19077165 chr18:44547161 KATNAL2 0.53 7.56 0.42 6.54e-13 Personality dimensions; CESC cis rs10779751 1.000 rs12120734 chr1:11262020 A/G cg08854313 chr1:11322531 MTOR 0.91 14.25 0.66 1.35e-34 Body mass index; CESC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -7.08 -0.4 1.3e-11 Developmental language disorder (linguistic errors); CESC cis rs6558174 0.802 rs6558170 chr8:22487388 C/G cg03733263 chr8:22462867 KIAA1967 0.43 5.2 0.3 3.95e-7 Breast cancer; CESC cis rs2839186 0.706 rs2839188 chr21:47692798 C/T cg10351095 chr21:47802916 PCNT -0.44 -5.56 -0.32 6.53e-8 Testicular germ cell tumor; CESC cis rs921968 0.541 rs561570 chr2:219379348 T/A cg02176678 chr2:219576539 TTLL4 0.5 9.03 0.48 3.72e-17 Mean corpuscular hemoglobin concentration; CESC cis rs1348850 0.567 rs3770009 chr2:178536544 C/T cg22681709 chr2:178499509 PDE11A -0.51 -7.47 -0.42 1.15e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs36051895 0.664 rs7847141 chr9:5097171 A/T cg02405213 chr9:5042618 JAK2 -0.5 -6.18 -0.35 2.44e-9 Pediatric autoimmune diseases; CESC cis rs9902453 0.967 rs4429345 chr17:28458105 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.61 -7.72 -0.43 2.44e-13 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05076971 chr7:117824189 NAA38 0.54 6.61 0.38 2.12e-10 Gut microbiome composition (summer); CESC cis rs2354432 0.607 rs6593751 chr1:146726023 A/G cg25205988 chr1:146714368 CHD1L -1.02 -8.47 -0.46 1.66e-15 Mitochondrial DNA levels; CESC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg01448562 chr3:133502909 NA -0.44 -6.1 -0.35 3.69e-9 Iron status biomarkers; CESC cis rs796364 0.951 rs11680258 chr2:200996976 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -6.48 -0.37 4.56e-10 Schizophrenia; CESC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.955 rs7684942 chr4:120162201 C/T cg24375607 chr4:120327624 NA 0.43 5.24 0.31 3.34e-7 Corneal astigmatism; CESC cis rs7666738 0.830 rs60391193 chr4:98933912 T/G cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4919694 1.000 rs12252500 chr10:104794984 G/C cg04362960 chr10:104952993 NT5C2 0.77 6.69 0.38 1.34e-10 Arsenic metabolism; CESC cis rs7208859 0.673 rs1347359 chr17:28914529 T/C cg14008862 chr17:28927542 LRRC37B2 0.66 5.75 0.33 2.39e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6942756 0.531 rs7800983 chr7:128971130 C/T cg02491457 chr7:128862824 NA 0.44 6.21 0.36 2.02e-9 White matter hyperintensity burden; CESC cis rs2463822 0.669 rs72919480 chr11:62043133 G/A cg06239285 chr11:62104954 ASRGL1 -1.13 -9.21 -0.49 1.05e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg22307029 chr19:49891270 CCDC155 0.49 5.35 0.31 1.86e-7 Multiple sclerosis; CESC cis rs12928939 0.517 rs12149325 chr16:71968147 G/C cg03805757 chr16:71968109 PKD1L3 -0.59 -6.62 -0.38 2.01e-10 Post bronchodilator FEV1; CESC cis rs782590 0.935 rs2627776 chr2:55873301 T/A cg18811423 chr2:55921094 PNPT1 0.81 13.07 0.63 1.89e-30 Metabolic syndrome; CESC cis rs601339 1.000 rs7969523 chr12:123168636 T/G cg11919336 chr12:123188078 GPR109A 0.45 5.86 0.34 1.36e-8 Adiponectin levels; CESC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg22800045 chr5:56110881 MAP3K1 -0.64 -7.54 -0.42 7.64e-13 Initial pursuit acceleration; CESC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg07870213 chr5:140052090 DND1 -0.61 -6.89 -0.39 4.01e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs13102973 0.931 rs116199858 chr4:135847256 G/C cg14419869 chr4:135874104 NA 0.33 5.19 0.3 4.29e-7 Subjective well-being; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08687137 chr11:62389499 B3GAT3 -0.49 -6.63 -0.38 1.83e-10 Fibrinogen levels; CESC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg04166393 chr7:2884313 GNA12 0.62 7.7 0.43 2.71e-13 Height; CESC cis rs10465746 0.658 rs980418 chr1:84365653 T/G cg10977910 chr1:84465055 TTLL7 0.56 7.78 0.43 1.62e-13 Obesity-related traits; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26558919 chr17:66508512 PRKAR1A -0.49 -6.15 -0.35 2.86e-9 Asthma; CESC cis rs2839186 0.934 rs4819221 chr21:47695417 G/T cg10351095 chr21:47802916 PCNT 0.48 6.57 0.37 2.67e-10 Testicular germ cell tumor; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07911682 chr1:51425659 FAF1 0.43 6.09 0.35 3.92e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6032067 0.777 rs17423897 chr20:43780307 T/C cg10761708 chr20:43804764 PI3 0.53 6.27 0.36 1.48e-9 Blood protein levels; CESC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg11764359 chr7:65958608 NA -0.8 -8.94 -0.48 6.67e-17 Aortic root size; CESC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg19468946 chr17:37922297 IKZF3 0.41 5.22 0.31 3.59e-7 Glomerular filtration rate (creatinine); CESC cis rs67311347 1.000 rs9827461 chr3:40489351 T/A cg24209194 chr3:40518798 ZNF619 0.5 6.18 0.35 2.46e-9 Renal cell carcinoma; CESC cis rs1843834 0.574 rs6436499 chr2:225456551 A/T cg22455342 chr2:225449267 CUL3 0.65 8.93 0.48 7.35e-17 IgE levels in asthmatics (D.p. specific); CESC cis rs262150 1.000 rs262150 chr7:158777934 G/A cg09640425 chr7:158790006 NA -0.35 -5.3 -0.31 2.48e-7 Facial morphology (factor 20); CESC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg08736216 chr1:53307985 ZYG11A -0.38 -6.35 -0.36 9.15e-10 Monocyte count; CESC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg02807482 chr3:125708958 NA -0.39 -5.11 -0.3 6.29e-7 Blood pressure (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20201475 chr3:168867307 MECOM 0.57 7.03 0.4 1.71e-11 Gut microbiome composition (summer); CESC cis rs367943 0.933 rs451453 chr5:112808970 G/C cg12552261 chr5:112820674 MCC -0.62 -7.85 -0.43 1.05e-13 Type 2 diabetes; CESC trans rs1728785 1.000 rs1615609 chr16:68596401 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.83 0.43 1.18e-13 Ulcerative colitis; CESC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg05368731 chr17:41323189 NBR1 0.78 10.64 0.55 2.97e-22 Menopause (age at onset); CESC cis rs965469 1.000 rs6051736 chr20:3296898 T/C cg25506879 chr20:3388711 C20orf194 -0.56 -6.08 -0.35 4.16e-9 IFN-related cytopenia; CESC cis rs9948 0.655 rs61742095 chr2:97366088 T/C cg01990225 chr2:97406019 LMAN2L -0.89 -6.97 -0.39 2.48e-11 Erectile dysfunction and prostate cancer treatment; CESC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg08736216 chr1:53307985 ZYG11A 0.43 7.25 0.41 4.64e-12 Monocyte count; CESC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg25985355 chr7:65971099 NA 0.32 5.35 0.31 1.9e-7 Aortic root size; CESC cis rs854765 0.547 rs2955359 chr17:17946730 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.81 -0.48 1.7e-16 Total body bone mineral density; CESC cis rs11098499 0.874 rs13139045 chr4:120168588 T/C cg09307838 chr4:120376055 NA 0.8 10.35 0.54 2.58e-21 Corneal astigmatism; CESC cis rs8067354 0.645 rs9901606 chr17:57811407 A/C cg13753209 chr17:57696993 CLTC 0.65 7.95 0.44 5.28e-14 Hemoglobin concentration; CESC cis rs9457247 0.663 rs9459845 chr6:167440501 C/G cg25258033 chr6:167368657 RNASET2 0.36 5.16 0.3 4.88e-7 Crohn's disease; CESC cis rs2228479 0.702 rs3819574 chr16:89826630 G/A cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.33e-10 Skin colour saturation; CESC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg03609598 chr5:56110824 MAP3K1 -0.51 -5.5 -0.32 9.11e-8 Initial pursuit acceleration; CESC cis rs12142240 0.698 rs67200518 chr1:46835777 T/C cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.1e-9 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00615915 chr18:61637299 SERPINB8 -0.44 -6.61 -0.38 2.12e-10 Gambling; CESC cis rs11098499 0.863 rs3775844 chr4:120428033 G/A cg09307838 chr4:120376055 NA 0.95 13.11 0.63 1.3e-30 Corneal astigmatism; CESC cis rs7312933 0.865 rs1920687 chr12:42398275 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.4 5.14 0.3 5.34e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs1401999 0.510 rs12634398 chr3:183708405 A/G cg01324343 chr3:183735012 ABCC5 0.39 6.76 0.38 8.51e-11 Anterior chamber depth; CESC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg24829409 chr8:58192753 C8orf71 -0.74 -8.44 -0.46 2.09e-15 Developmental language disorder (linguistic errors); CESC cis rs1865721 1.000 rs3813080 chr18:73186227 C/T cg26385618 chr18:73139727 C18orf62 -0.52 -7.77 -0.43 1.68e-13 Intelligence; CESC cis rs17376456 0.825 rs56108532 chr5:93276342 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.67 5.72 0.33 2.86e-8 Diabetic retinopathy; CESC cis rs6893300 0.961 rs1469020 chr5:179214024 G/A cg14593053 chr5:179126677 CANX -0.51 -5.57 -0.32 6.16e-8 Resting heart rate; CESC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.51 -5.7 -0.33 3.21e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg15664640 chr17:80829946 TBCD 0.42 6.07 0.35 4.3e-9 Breast cancer; CESC cis rs79349575 0.783 rs62078372 chr17:47028989 T/C cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs826838 0.967 rs11169142 chr12:39085773 A/T cg26384229 chr12:38710491 ALG10B -0.62 -9.95 -0.52 5e-20 Heart rate; CESC cis rs7914558 0.966 rs3902934 chr10:104746649 A/G cg08650961 chr10:104748594 CNNM2 0.32 5.14 0.3 5.23e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23957188 chr1:115124358 BCAS2 -0.56 -6.56 -0.37 2.79e-10 Gut microbiome composition (summer); CESC cis rs11098499 0.604 rs34278750 chr4:120571136 G/A cg24375607 chr4:120327624 NA 0.44 5.35 0.31 1.87e-7 Corneal astigmatism; CESC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg13607699 chr17:42295918 UBTF 0.57 7.31 0.41 3.2e-12 Total body bone mineral density; CESC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg00149659 chr3:10157352 C3orf10 0.71 8.4 0.46 2.71e-15 Alzheimer's disease; CESC cis rs8180040 1.000 rs295449 chr3:47375955 G/A cg27129171 chr3:47204927 SETD2 0.67 10.1 0.53 1.72e-20 Colorectal cancer; CESC cis rs941408 1.000 rs1736176 chr19:2790394 G/A cg06609049 chr19:2785107 THOP1 0.73 10.6 0.55 4.06e-22 Total cholesterol levels; CESC cis rs2204008 0.905 rs7294297 chr12:38442573 T/C cg26384229 chr12:38710491 ALG10B 0.64 9.46 0.5 1.69e-18 Bladder cancer; CESC cis rs72945132 1.000 rs7938912 chr11:70114885 C/T cg00319359 chr11:70116639 PPFIA1 0.84 8.25 0.45 7.56e-15 Coronary artery disease; CESC cis rs9733 0.519 rs1134067 chr1:150721175 G/T cg18016565 chr1:150552671 MCL1 0.35 5.11 0.3 6.05e-7 Tonsillectomy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11582133 chr15:41576691 LOC729082 -0.43 -6.11 -0.35 3.47e-9 Gambling; CESC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg19163074 chr7:65112434 INTS4L2 -0.46 -5.05 -0.3 8.07e-7 Aortic root size; CESC cis rs714031 0.872 rs3788576 chr22:40071894 G/A cg21377881 chr22:40064566 CACNA1I -0.36 -5.92 -0.34 9.97e-9 Schizophrenia; CESC cis rs262150 0.851 rs2730249 chr7:158767628 A/G cg19418458 chr7:158789849 NA 0.5 7.94 0.44 5.61e-14 Facial morphology (factor 20); CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg10678486 chr18:48494218 ELAC1 0.53 6.03 0.35 5.46e-9 Endometrial cancer; CESC cis rs2204008 0.806 rs11525001 chr12:38234397 A/G cg26384229 chr12:38710491 ALG10B 0.64 8.91 0.48 8.24e-17 Bladder cancer; CESC cis rs2979489 0.945 rs13250272 chr8:30294942 A/G cg26383811 chr8:30366931 RBPMS 0.83 9.69 0.51 3.31e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs7953508 0.506 rs768775 chr12:93968197 T/C cg18151635 chr12:93972918 NA -0.44 -5.89 -0.34 1.19e-8 Pubertal anthropometrics; CESC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg04414720 chr1:150670196 GOLPH3L 0.62 8.8 0.48 1.76e-16 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21906083 chr1:160772137 LY9 -0.59 -7.0 -0.4 2.05e-11 Gut microbiome composition (summer); CESC cis rs3796352 1.000 rs4478072 chr3:53106125 G/T cg12962167 chr3:53033115 SFMBT1 0.56 5.82 0.34 1.72e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg00149659 chr3:10157352 C3orf10 0.77 9.66 0.51 4.22e-19 Alzheimer's disease; CESC cis rs941408 0.515 rs1005556 chr19:2778543 G/T cg06609049 chr19:2785107 THOP1 0.85 13.07 0.63 1.76e-30 Total cholesterol levels; CESC cis rs34172651 0.876 rs1862451 chr16:24803620 A/G cg06028605 chr16:24865363 SLC5A11 0.41 6.22 0.36 1.94e-9 Intelligence (multi-trait analysis); CESC cis rs1559088 1.000 rs12979164 chr19:33553228 G/C cg17764715 chr19:33622953 WDR88 0.45 5.68 0.33 3.6e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4588572 0.686 rs2362823 chr5:77693623 A/G cg11547950 chr5:77652471 NA 0.46 5.98 0.34 7.29e-9 Triglycerides; CESC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg00934597 chr7:893267 UNC84A 0.47 5.17 0.3 4.72e-7 Cerebrospinal P-tau181p levels; CESC cis rs2286492 0.881 rs78433057 chr7:22930238 A/G cg05472934 chr7:22766657 IL6 -0.69 -5.13 -0.3 5.59e-7 Bipolar disorder; CESC cis rs10992471 0.565 rs12552866 chr9:95110549 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.04 -0.3 8.5e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs35079168 0.735 rs1887309 chr9:137308242 A/G cg00753924 chr9:137298813 RXRA 0.4 6.38 0.36 7.98e-10 Intelligence; CESC cis rs5753037 0.653 rs131282 chr22:30156608 A/C cg01021169 chr22:30184971 ASCC2 -0.44 -6.01 -0.35 6.28e-9 Type 1 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06239170 chr6:657134 HUS1B;EXOC2 0.53 7.16 0.4 7.95e-12 Fibrinogen levels; CESC cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.04 0.3 8.5e-7 Hip circumference adjusted for BMI; CESC cis rs1215050 0.791 rs1648546 chr4:98899294 T/C cg05340658 chr4:99064831 C4orf37 -0.53 -7.0 -0.39 2.14e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs3733585 0.699 rs7694997 chr4:9947811 A/G cg11266682 chr4:10021025 SLC2A9 -0.58 -10.78 -0.55 1.08e-22 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02921634 chr21:43109546 NCRNA00111 -0.57 -6.31 -0.36 1.16e-9 Gut microbiome composition (summer); CESC trans rs1493916 0.721 rs4799723 chr18:31367050 T/G cg27147174 chr7:100797783 AP1S1 -0.49 -6.43 -0.37 5.75e-10 Life satisfaction; CESC cis rs41308713 0.786 rs8116471 chr20:37034694 A/C cg09132763 chr20:37064059 LOC388796;SNORA71D 1.13 6.51 0.37 3.77e-10 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC trans rs11098499 0.874 rs6832670 chr4:120118792 A/G cg25214090 chr10:38739885 LOC399744 0.61 8.1 0.45 2.06e-14 Corneal astigmatism; CESC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg16405210 chr4:1374714 KIAA1530 0.45 5.58 0.32 5.89e-8 Obesity-related traits; CESC cis rs2522056 1.000 rs2706381 chr5:131810619 C/T cg07395648 chr5:131743802 NA 0.43 5.06 0.3 8.01e-7 Lymphocyte counts;Fibrinogen; CESC cis rs7617773 1.000 rs6442106 chr3:48190815 G/A cg11946769 chr3:48343235 NME6 -0.62 -8.23 -0.45 8.76e-15 Coronary artery disease; CESC cis rs2342371 0.756 rs3973 chr3:196124278 A/G cg09821211 chr3:195954098 OSTalpha -0.37 -5.3 -0.31 2.46e-7 Fat distribution (HIV); CESC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg22433210 chr17:43662623 NA -0.58 -7.27 -0.41 4.13e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2487048 0.761 rs1800976 chr9:107690709 C/G cg14470647 chr9:107690075 ABCA1 -0.58 -7.29 -0.41 3.6e-12 Intraocular pressure; CESC cis rs9888739 0.858 rs60312440 chr16:31340086 C/T cg15817542 chr16:31343056 ITGAM -0.49 -6.64 -0.38 1.76e-10 Systemic lupus erythematosus; CESC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg19592336 chr6:28129416 ZNF389 0.58 7.65 0.43 3.83e-13 Depression; CESC cis rs6570726 0.967 rs418662 chr6:145848832 A/C cg23711669 chr6:146136114 FBXO30 0.74 10.72 0.55 1.65e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs8072100 0.738 rs9915222 chr17:45448615 G/T cg08085267 chr17:45401833 C17orf57 -0.51 -6.35 -0.36 9.29e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg06108461 chr20:60628389 TAF4 -0.83 -11.36 -0.57 1.24e-24 Body mass index; CESC cis rs7264396 0.580 rs2064511 chr20:34448810 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.62 -6.38 -0.36 7.83e-10 Total cholesterol levels; CESC cis rs7666738 0.830 rs9998582 chr4:98938949 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs250677 0.652 rs250680 chr5:148436024 T/C cg18129178 chr5:148520854 ABLIM3 -0.48 -5.48 -0.32 1e-7 Breast cancer; CESC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg07701084 chr6:150067640 NUP43 0.46 6.45 0.37 5.26e-10 Lung cancer; CESC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg11764359 chr7:65958608 NA 0.81 9.69 0.51 3.42e-19 Aortic root size; CESC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg05564831 chr3:52568323 NT5DC2 0.48 7.64 0.42 3.95e-13 Bipolar disorder; CESC cis rs8177179 1.000 rs8177179 chr3:133463457 G/A cg17775713 chr3:133465469 TF 0.32 5.71 0.33 3.1e-8 Iron status biomarkers (transferrin levels); CESC trans rs35110281 0.782 rs9981790 chr21:45045052 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.46 0.37 4.98e-10 Mean corpuscular volume; CESC cis rs10089 0.951 rs56066100 chr5:127460571 G/C cg19767477 chr5:127420684 SLC12A2 -0.4 -5.32 -0.31 2.18e-7 Ileal carcinoids; CESC cis rs11997175 0.624 rs17778980 chr8:33700926 T/C ch.8.33884649F chr8:33765107 NA 0.56 7.34 0.41 2.56e-12 Body mass index; CESC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC trans rs2727020 0.894 rs2866361 chr11:49372481 A/G cg03929089 chr4:120376271 NA -0.65 -7.61 -0.42 4.67e-13 Coronary artery disease; CESC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg11764359 chr7:65958608 NA 0.9 13.28 0.63 3.47e-31 Aortic root size; CESC cis rs4642101 0.793 rs12714880 chr3:12832101 G/A cg24848339 chr3:12840334 CAND2 0.35 5.4 0.31 1.48e-7 QRS complex (12-leadsum); CESC cis rs863345 0.933 rs863354 chr1:158542460 A/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.38 -0.36 7.87e-10 Pneumococcal bacteremia; CESC cis rs6430585 0.527 rs1438303 chr2:136429857 C/T cg07169764 chr2:136633963 MCM6 1.06 12.0 0.59 9.01e-27 Corneal structure; CESC cis rs2108622 0.727 rs7253873 chr19:15980900 A/G cg13772218 chr19:15982569 NA 0.3 5.87 0.34 1.27e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs1506636 0.962 rs629474 chr7:123399684 C/T cg03229431 chr7:123269106 ASB15 0.53 6.95 0.39 2.89e-11 Plateletcrit;Platelet count; CESC cis rs10489202 0.632 rs203781 chr1:167880518 A/C cg24449463 chr1:168025552 DCAF6 -0.43 -5.61 -0.33 5.03e-8 Schizophrenia; CESC cis rs2239547 0.522 rs9865094 chr3:52985319 G/C cg11645453 chr3:52864694 ITIH4 -0.32 -5.39 -0.31 1.53e-7 Schizophrenia; CESC trans rs10435719 0.718 rs7813935 chr8:11795636 A/G cg15556689 chr8:8085844 FLJ10661 0.53 6.47 0.37 4.63e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg02487422 chr3:49467188 NICN1 0.4 5.22 0.31 3.6e-7 Parkinson's disease; CESC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs1372520 0.745 rs2736994 chr4:90784528 A/G cg15133208 chr4:90757351 SNCA -0.42 -5.46 -0.32 1.07e-7 Neuroticism; CESC cis rs11920090 0.789 rs73169742 chr3:170756779 C/T cg09710316 chr3:170744871 SLC2A2 0.51 5.43 0.32 1.28e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22185043 chr18:12947723 SEH1L 0.61 7.17 0.4 7.51e-12 Gut microbiome composition (summer); CESC cis rs2832077 0.527 rs2142375 chr21:30223742 G/A cg08807101 chr21:30365312 RNF160 -0.66 -8.57 -0.47 8.73e-16 Cognitive test performance; CESC cis rs9399135 0.967 rs7773126 chr6:135318390 A/G cg24558204 chr6:135376177 HBS1L 0.5 6.77 0.38 8.49e-11 Red blood cell count; CESC cis rs1483890 0.723 rs1843046 chr3:69410614 C/A cg22125112 chr3:69402811 FRMD4B 0.41 5.53 0.32 7.56e-8 Resting heart rate; CESC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.75 -8.81 -0.48 1.68e-16 Gut microbiome composition (summer); CESC cis rs7274811 0.779 rs34145153 chr20:32159067 C/T cg21523528 chr20:32077966 CBFA2T2 0.61 7.14 0.4 8.96e-12 Height; CESC cis rs265548 0.646 rs36689 chr19:17910639 A/G cg16744531 chr19:17905626 B3GNT3 0.58 8.09 0.45 2.16e-14 Tumor biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18865566 chr20:32274387 E2F1 0.59 6.18 0.35 2.45e-9 Gut microbiome composition (summer); CESC cis rs7640424 0.819 rs179046 chr3:107840773 A/C cg09227934 chr3:107805635 CD47 -0.47 -6.03 -0.35 5.57e-9 Body mass index; CESC cis rs34779708 0.897 rs34481177 chr10:35380913 C/T cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs11825685 0.790 rs80204957 chr11:134545553 A/T cg06603561 chr11:134479413 NA -0.61 -5.35 -0.31 1.89e-7 IgG glycosylation; CESC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg11644478 chr21:40555479 PSMG1 -0.55 -7.36 -0.41 2.39e-12 Menarche (age at onset); CESC cis rs11650494 0.710 rs76651802 chr17:47473785 A/G cg08112188 chr17:47440006 ZNF652 0.83 6.31 0.36 1.17e-9 Prostate cancer; CESC trans rs11098499 0.863 rs11933966 chr4:120476715 G/A cg25214090 chr10:38739885 LOC399744 0.66 8.96 0.48 5.92e-17 Corneal astigmatism; CESC cis rs806215 1.000 rs806216 chr7:127237862 C/A cg25922125 chr7:127225783 GCC1 -0.45 -5.23 -0.31 3.51e-7 Type 2 diabetes; CESC trans rs17685 0.712 rs10271413 chr7:75754858 G/A cg19862616 chr7:65841803 NCRNA00174 0.85 12.55 0.61 1.13e-28 Coffee consumption;Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00635599 chr16:14165630 MKL2 0.63 6.74 0.38 9.6e-11 Gut microbiome composition (summer); CESC cis rs7551222 0.663 rs1563828 chr1:204516577 A/G cg20240347 chr1:204465584 NA -0.29 -5.93 -0.34 9.39e-9 Schizophrenia; CESC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg22800045 chr5:56110881 MAP3K1 -0.75 -9.47 -0.5 1.61e-18 Initial pursuit acceleration; CESC cis rs17253792 0.822 rs113649689 chr14:56088065 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs2228479 0.702 rs11646374 chr16:89857935 G/A cg04013166 chr16:89971882 TCF25 0.77 6.64 0.38 1.81e-10 Skin colour saturation; CESC cis rs12410462 0.581 rs7541809 chr1:227547299 G/A cg04117972 chr1:227635322 NA 0.62 5.31 0.31 2.27e-7 Major depressive disorder; CESC cis rs8067545 0.611 rs8071274 chr17:20216928 T/C cg13482628 chr17:19912719 NA -0.41 -5.35 -0.31 1.94e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24729577 chr1:1447567 ATAD3A 0.67 8.2 0.45 1.05e-14 Gut microbiome composition (summer); CESC cis rs2380220 0.510 rs9387562 chr6:96057006 G/T cg23517279 chr6:96025343 MANEA 0.54 5.23 0.31 3.5e-7 Behavioural disinhibition (generation interaction); CESC cis rs921968 0.541 rs549026 chr2:219339283 T/C cg02176678 chr2:219576539 TTLL4 0.5 8.97 0.48 5.67e-17 Mean corpuscular hemoglobin concentration; CESC cis rs4319547 0.656 rs10734918 chr12:122921512 A/C cg05707623 chr12:122985044 ZCCHC8 -0.53 -6.08 -0.35 4.2e-9 Body mass index; CESC cis rs3008870 1.000 rs2815352 chr1:67482104 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 13.5 0.64 5.92e-32 Lymphocyte percentage of white cells; CESC cis rs10751667 0.666 rs7950967 chr11:955638 G/A cg01483505 chr11:975446 AP2A2 0.37 5.05 0.3 8.3e-7 Alzheimer's disease (late onset); CESC cis rs757081 0.867 rs2521999 chr11:17333183 G/A cg15432903 chr11:17409602 KCNJ11 -0.48 -6.03 -0.35 5.49e-9 Systolic blood pressure; CESC cis rs7524258 0.867 rs35399313 chr1:7277293 T/C cg07173049 chr1:7289937 CAMTA1 0.37 5.6 0.33 5.26e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs992157 0.687 rs35271699 chr2:219117482 G/A cg00012203 chr2:219082015 ARPC2 0.83 11.63 0.58 1.52e-25 Colorectal cancer; CESC cis rs1975974 0.511 rs56935892 chr17:21754089 A/G cg18423549 chr17:21743878 NA -0.67 -10.06 -0.53 2.2e-20 Psoriasis; CESC cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg12386194 chr3:101231763 SENP7 0.57 6.58 0.37 2.48e-10 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22187246 chr11:71849870 FOLR3 0.44 6.05 0.35 4.99e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.45 0.77 5.95e-53 Height; CESC cis rs9894429 0.789 rs7219915 chr17:79591813 C/T cg13777783 chr17:79615861 NA -0.33 -5.23 -0.31 3.45e-7 Eye color traits; CESC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.63 0.64 2.03e-32 Prudent dietary pattern; CESC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg19163074 chr7:65112434 INTS4L2 0.43 5.48 0.32 9.93e-8 Aortic root size; CESC cis rs9910055 0.529 rs368328 chr17:42170289 G/A cg19774624 chr17:42201019 HDAC5 0.57 7.45 0.42 1.3e-12 Total body bone mineral density; CESC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs763121 0.719 rs9610995 chr22:39057763 C/T cg21395723 chr22:39101663 GTPBP1 0.43 5.37 0.31 1.74e-7 Menopause (age at onset); CESC cis rs9467711 0.659 rs3823158 chr6:26463271 T/A cg21479132 chr6:26055353 NA 0.72 5.14 0.3 5.22e-7 Autism spectrum disorder or schizophrenia; CESC cis rs4319547 1.000 rs9705654 chr12:123083508 T/C cg23029597 chr12:123009494 RSRC2 -0.46 -5.26 -0.31 3.04e-7 Body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21647170 chr7:56119546 CCT6A;PSPH -0.44 -6.25 -0.36 1.66e-9 Gambling; CESC cis rs9814567 0.929 rs13088413 chr3:134309977 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.03 0.35 5.55e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6121246 0.559 rs6060857 chr20:30300222 A/G cg13852791 chr20:30311386 BCL2L1 0.86 11.25 0.57 2.93e-24 Mean corpuscular hemoglobin; CESC cis rs9291683 0.588 rs2240721 chr4:10020564 G/A cg00071950 chr4:10020882 SLC2A9 0.92 17.67 0.74 1.1e-46 Bone mineral density; CESC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.8 0.65 5.22e-33 Prudent dietary pattern; CESC cis rs72781680 0.846 rs55707417 chr2:24029928 G/A cg08917208 chr2:24149416 ATAD2B 1.13 10.18 0.53 9.42e-21 Lymphocyte counts; CESC cis rs10851478 0.872 rs12595692 chr15:49757108 C/T cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.16 0.3 4.79e-7 Oral cavity cancer; CESC cis rs6500395 0.962 rs1872652 chr16:48642928 C/A cg04672837 chr16:48644449 N4BP1 0.47 5.58 0.32 6.09e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2730245 0.661 rs842696 chr7:158662698 T/C cg24397884 chr7:158709396 WDR60 0.69 10.14 0.53 1.23e-20 Height; CESC cis rs1448094 0.621 rs7315084 chr12:86283817 A/G cg02569458 chr12:86230093 RASSF9 0.41 6.12 0.35 3.43e-9 Major depressive disorder; CESC cis rs977987 0.778 rs1109341 chr16:75445605 G/A cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.66e-8 Dupuytren's disease; CESC cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.26 0.31 2.99e-7 Personality dimensions; CESC cis rs68170813 0.559 rs74745121 chr7:106958037 T/C cg02696742 chr7:106810147 HBP1 -0.53 -5.04 -0.3 8.64e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08249556 chr21:30365104 RNF160 0.57 6.18 0.35 2.47e-9 Gut microbiome composition (summer); CESC cis rs9457247 0.508 rs2285147 chr6:167505548 G/A cg07741184 chr6:167504864 NA 0.32 5.49 0.32 9.4e-8 Crohn's disease; CESC cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.86 0.34 1.33e-8 Tonsillectomy; CESC cis rs2282526 0.615 rs463738 chr21:44921166 G/A cg01579765 chr21:45077557 HSF2BP 0.41 6.17 0.35 2.57e-9 Mean corpuscular hemoglobin; CESC cis rs9868809 0.772 rs12107252 chr3:48691316 T/C cg06212747 chr3:49208901 KLHDC8B -0.64 -5.63 -0.33 4.55e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg11752832 chr7:134001865 SLC35B4 0.54 7.0 0.4 2.04e-11 Mean platelet volume; CESC cis rs9768139 0.733 rs10156158 chr7:158122287 G/T cg06219351 chr7:158114137 PTPRN2 -0.52 -8.13 -0.45 1.63e-14 Calcium levels; CESC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg08470875 chr2:26401718 FAM59B -0.46 -5.14 -0.3 5.45e-7 Gut microbiome composition (summer); CESC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg16680214 chr1:154839983 KCNN3 -0.41 -6.13 -0.35 3.11e-9 Prostate cancer; CESC cis rs7635838 0.859 rs9869977 chr3:11480081 C/A cg00170343 chr3:11313890 ATG7 0.42 5.6 0.33 5.25e-8 HDL cholesterol; CESC cis rs965469 1.000 rs6051702 chr20:3251924 A/C cg25506879 chr20:3388711 C20orf194 -0.59 -6.27 -0.36 1.48e-9 IFN-related cytopenia; CESC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg09509183 chr1:209979624 IRF6 -0.37 -5.08 -0.3 6.98e-7 Orofacial clefts; CESC cis rs59918340 0.728 rs2304279 chr8:142229891 A/G cg23750338 chr8:142222470 SLC45A4 0.61 9.17 0.49 1.41e-17 Immature fraction of reticulocytes; CESC cis rs9815354 0.767 rs73073342 chr3:41839455 A/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs1670533 1.000 rs2290411 chr4:1051077 T/C cg27284194 chr4:1044797 NA 0.45 5.54 0.32 7.32e-8 Recombination rate (females); CESC cis rs4835473 0.900 rs36083417 chr4:144655406 T/A cg25736465 chr4:144833511 NA -0.32 -5.04 -0.3 8.48e-7 Immature fraction of reticulocytes; CESC cis rs3820068 0.581 rs72645879 chr1:15928199 A/G cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs4073405 0.552 rs2289448 chr11:45305195 C/T cg27235148 chr11:45376932 NA 0.29 5.04 0.3 8.55e-7 Schizophrenia; CESC cis rs7267979 1.000 rs6076336 chr20:25319212 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -18.7 -0.75 2.48e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs1670533 1.000 rs1010342 chr4:1068819 C/T cg27284194 chr4:1044797 NA 0.45 5.98 0.34 7.06e-9 Recombination rate (females); CESC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg00149659 chr3:10157352 C3orf10 0.72 8.53 0.46 1.14e-15 Alzheimer's disease; CESC cis rs782590 1.000 rs782594 chr2:55844445 T/C cg18811423 chr2:55921094 PNPT1 0.81 13.08 0.63 1.7e-30 Metabolic syndrome; CESC cis rs6540559 0.546 rs634601 chr1:210421594 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.55 6.15 0.35 2.87e-9 Cleft lip with or without cleft palate; CESC cis rs870825 0.616 rs12512839 chr4:185610347 G/A cg04058563 chr4:185651563 MLF1IP 0.64 6.46 0.37 5e-10 Blood protein levels; CESC cis rs9314323 0.862 rs3808580 chr8:26250296 C/T cg11498726 chr8:26250323 BNIP3L 0.45 6.74 0.38 9.87e-11 Red cell distribution width; CESC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs9393777 0.623 rs9366658 chr6:26469866 G/A cg12826209 chr6:26865740 GUSBL1 0.68 7.35 0.41 2.43e-12 Intelligence (multi-trait analysis); CESC cis rs11098499 0.779 rs72918579 chr4:120333222 G/C cg09307838 chr4:120376055 NA 0.95 13.42 0.64 1.07e-31 Corneal astigmatism; CESC cis rs11577318 0.853 rs12728971 chr1:26626612 C/T cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.46 -0.37 5.05e-10 Granulocyte percentage of myeloid white cells; CESC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg17372223 chr3:52568218 NT5DC2 0.44 6.53 0.37 3.36e-10 Bipolar disorder; CESC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg25036284 chr2:26402008 FAM59B -0.74 -8.4 -0.46 2.72e-15 Gut microbiome composition (summer); CESC cis rs6598955 0.543 rs79778574 chr1:26538482 A/G cg04990556 chr1:26633338 UBXN11 0.82 9.33 0.5 4.37e-18 Obesity-related traits; CESC cis rs1801251 1.000 rs2100053 chr2:233719516 G/T cg08000102 chr2:233561755 GIGYF2 -0.71 -10.22 -0.53 6.85e-21 Coronary artery disease; CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg23708337 chr7:1209742 NA 0.5 5.57 0.32 6.3e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4478858 0.735 rs11436 chr1:31837320 T/C cg00250761 chr1:31883323 NA -0.26 -5.07 -0.3 7.56e-7 Alcohol dependence; CESC cis rs8028182 0.666 rs4886708 chr15:75762608 C/T cg20655648 chr15:75932815 IMP3 0.48 6.07 0.35 4.41e-9 Sudden cardiac arrest; CESC cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg11752832 chr7:134001865 SLC35B4 0.54 7.09 0.4 1.19e-11 Mean platelet volume; CESC cis rs2243480 0.831 rs57294491 chr7:65684901 T/A cg18252515 chr7:66147081 NA 1.37 13.59 0.64 2.8e-32 Diabetic kidney disease; CESC trans rs1814175 0.616 rs28417656 chr11:50040152 C/T cg03929089 chr4:120376271 NA -0.91 -14.82 -0.67 1.29e-36 Height; CESC cis rs12701220 0.503 rs12702047 chr7:1132720 G/A cg26769984 chr7:1090371 C7orf50 0.57 5.69 0.33 3.38e-8 Bronchopulmonary dysplasia; CESC cis rs2777491 0.872 rs7176588 chr15:41588872 C/T cg18705301 chr15:41695430 NDUFAF1 -0.59 -8.9 -0.48 8.93e-17 Ulcerative colitis; CESC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg12373951 chr3:133503437 NA -0.36 -5.52 -0.32 8.2e-8 Iron status biomarkers; CESC cis rs111326718 1 rs111326718 chr10:104771211 A/AAAAAT cg15744005 chr10:104629667 AS3MT -0.34 -5.51 -0.32 8.56e-8 Reticulocyte count; CESC cis rs9287719 0.967 rs7600728 chr2:10739999 A/G cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg04315214 chr1:2043799 PRKCZ -0.46 -7.58 -0.42 5.86e-13 Height; CESC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg26314531 chr2:26401878 FAM59B -0.62 -7.09 -0.4 1.25e-11 Gut microbiome composition (summer); CESC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg19163074 chr7:65112434 INTS4L2 0.46 5.05 0.3 8.07e-7 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22913584 chr5:81046758 SSBP2 -0.44 -6.19 -0.36 2.3e-9 Gut microbiota (bacterial taxa); CESC cis rs7927771 0.524 rs1563821 chr11:47756568 C/T cg18512352 chr11:47633146 NA 0.35 5.51 0.32 8.36e-8 Subjective well-being; CESC cis rs4589502 0.800 rs2035150 chr15:67201794 A/C cg09911534 chr15:67153556 NA 0.38 5.06 0.3 7.76e-7 Lung cancer (smoking interaction); CESC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg13777783 chr17:79615861 NA 0.35 5.79 0.34 1.99e-8 Eye color traits; CESC cis rs8020095 0.528 rs10144122 chr14:67856690 A/G cg19548862 chr14:67692701 FAM71D -0.45 -5.26 -0.31 2.98e-7 Depression (quantitative trait); CESC cis rs9916302 0.904 rs4795359 chr17:37573146 C/T cg07936489 chr17:37558343 FBXL20 -0.8 -11.5 -0.58 4.2e-25 Glomerular filtration rate (creatinine); CESC cis rs6912958 0.631 rs9450704 chr6:88182704 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.15 -0.3 5.1e-7 Monocyte percentage of white cells; CESC cis rs9894429 0.789 rs9747336 chr17:79584189 C/T cg18240062 chr17:79603768 NPLOC4 0.89 13.21 0.63 6.03e-31 Eye color traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05840127 chr12:3181055 NA -0.38 -6.26 -0.36 1.56e-9 Gut microbiota (bacterial taxa); CESC cis rs6429082 0.764 rs291369 chr1:235691913 T/C cg26050004 chr1:235667680 B3GALNT2 0.6 7.29 0.41 3.49e-12 Adiposity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03956243 chr12:54059090 ATP5G2 -0.46 -6.44 -0.37 5.51e-10 Gut microbiota (bacterial taxa); CESC cis rs9549260 0.564 rs9315784 chr13:41289166 G/A cg21288729 chr13:41239152 FOXO1 0.58 7.04 0.4 1.63e-11 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26450010 chr19:17412054 ABHD8 -0.6 -6.94 -0.39 2.94e-11 Gut microbiome composition (summer); CESC cis rs4909189 1.000 rs71547530 chr7:158135503 A/G cg06219351 chr7:158114137 PTPRN2 -0.58 -7.2 -0.4 6.3e-12 Response to amphetamines; CESC cis rs7851660 0.967 rs7860598 chr9:100600702 G/A cg13688889 chr9:100608707 NA -0.68 -10.61 -0.55 3.8e-22 Strep throat; CESC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg07701084 chr6:150067640 NUP43 0.43 5.81 0.34 1.79e-8 Lung cancer; CESC cis rs2439831 0.850 rs61390361 chr15:44159842 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.43 0.42 1.45e-12 Lung cancer in ever smokers; CESC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg18350739 chr11:68623251 NA -0.46 -6.98 -0.39 2.41e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1551570 0.766 rs55752217 chr19:10218434 C/T cg00593900 chr19:10206746 ANGPTL6 0.33 5.53 0.32 7.57e-8 Narcolepsy; CESC cis rs3126085 0.935 rs12746239 chr1:152246726 G/A cg03465714 chr1:152285911 FLG 0.5 5.98 0.34 7.27e-9 Atopic dermatitis; CESC cis rs2243480 1.000 rs1979823 chr7:65704613 G/A cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs2235642 0.750 rs2974845 chr16:1648162 T/C cg03771183 chr16:1608904 IFT140 0.38 5.43 0.32 1.3e-7 Coronary artery disease; CESC cis rs34172651 0.606 rs7194189 chr16:24703484 G/T cg00339695 chr16:24857497 SLC5A11 -0.45 -6.02 -0.35 5.88e-9 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg17949981 chr6:28129498 ZNF389 0.42 5.23 0.31 3.39e-7 Depression; CESC cis rs1577917 0.958 rs12205492 chr6:86475976 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -6.82 -0.39 5.97e-11 Response to antipsychotic treatment; CESC cis rs7267979 0.966 rs2387882 chr20:25378802 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.92e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs11098499 0.697 rs11941899 chr4:120382758 C/A cg25214090 chr10:38739885 LOC399744 0.69 9.79 0.52 1.58e-19 Corneal astigmatism; CESC cis rs2286503 0.780 rs1304431 chr7:22865412 T/C cg11367502 chr7:22862612 TOMM7 0.42 5.61 0.33 5e-8 Fibrinogen; CESC cis rs4474465 0.688 rs10899553 chr11:78265210 A/G cg27205649 chr11:78285834 NARS2 0.45 5.55 0.32 6.77e-8 Alzheimer's disease (survival time); CESC cis rs6964587 0.626 rs2106745 chr7:91506635 C/T cg17063962 chr7:91808500 NA -0.45 -6.28 -0.36 1.38e-9 Breast cancer; CESC cis rs35110281 0.641 rs9983670 chr21:45083425 A/G cg04455712 chr21:45112962 RRP1B 0.5 7.86 0.43 9.82e-14 Mean corpuscular volume; CESC cis rs7524258 0.903 rs4908450 chr1:7292756 T/C cg07173049 chr1:7289937 CAMTA1 0.47 7.15 0.4 8.5e-12 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs4953076 0.573 rs6734443 chr2:44408282 G/C cg04920474 chr2:44395004 PPM1B 0.56 7.07 0.4 1.37e-11 Height; CESC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.65e-39 Menopause (age at onset); CESC cis rs854765 0.575 rs2955357 chr17:17946401 T/C cg04398451 chr17:18023971 MYO15A 0.72 10.46 0.54 1.15e-21 Total body bone mineral density; CESC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.955 rs1551 chr4:120158500 T/G cg24375607 chr4:120327624 NA 0.43 5.17 0.3 4.57e-7 Corneal astigmatism; CESC cis rs11871801 0.517 rs665268 chr17:40722029 A/G cg21433558 chr17:40837037 CNTNAP1 0.48 5.9 0.34 1.11e-8 Crohn's disease; CESC cis rs10838687 0.800 rs7928073 chr11:47361857 C/T cg25783544 chr11:47291846 MADD 0.56 6.27 0.36 1.43e-9 Proinsulin levels; CESC cis rs116095464 0.558 rs62344300 chr5:246336 A/G cg10591111 chr5:226296 SDHA -0.52 -6.38 -0.36 7.94e-10 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09915983 chr20:2844691 VPS16;PTPRA -0.54 -6.59 -0.38 2.31e-10 Gut microbiome composition (summer); CESC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.07 0.53 2.14e-20 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05407442 chr14:68161980 RDH11 -0.61 -7.29 -0.41 3.63e-12 Gut microbiome composition (summer); CESC cis rs703842 0.616 rs10877023 chr12:58224199 C/A cg00677455 chr12:58241039 CTDSP2 0.76 10.4 0.54 1.75e-21 Multiple sclerosis; CESC cis rs68092024 0.704 rs792832 chr3:99474862 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.43 -6.77 -0.38 8.4e-11 Cleft lip with or without cleft palate; CESC cis rs12545109 0.571 rs4314648 chr8:57276937 G/A cg09654669 chr8:57350985 NA -0.56 -6.21 -0.36 2.05e-9 Obesity-related traits; CESC trans rs12339966 0.689 rs2252360 chr9:11677175 C/G cg03904639 chr13:37677730 CSNK1A1L -0.39 -6.1 -0.35 3.74e-9 Systolic blood pressure; CESC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.38 -0.31 1.61e-7 Total body bone mineral density; CESC cis rs11792861 0.890 rs3087979 chr9:111781779 T/C cg14384093 chr9:111878565 C9orf5 -0.41 -5.05 -0.3 8.32e-7 Menarche (age at onset); CESC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg14061069 chr19:46274453 DMPK 0.56 8.73 0.47 2.97e-16 Coronary artery disease; CESC cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg13147721 chr7:65941812 NA -0.89 -8.5 -0.46 1.43e-15 Diabetic kidney disease; CESC cis rs2290159 0.800 rs28462331 chr3:12660466 G/C cg23032965 chr3:12705835 RAF1 0.53 5.68 0.33 3.58e-8 Cholesterol, total; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06128920 chr1:1447374 ATAD3A -0.43 -6.09 -0.35 3.95e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs644799 0.710 rs3748253 chr11:95519506 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.75 11.15 0.57 6.1e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs67311347 1.000 rs56291770 chr3:40515370 T/C cg09455208 chr3:40491958 NA 0.51 8.34 0.46 4.1e-15 Renal cell carcinoma; CESC cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg05347473 chr6:146136440 FBXO30 0.73 9.58 0.51 7.28e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs7818345 1.000 rs11780343 chr8:19290963 C/T cg11303988 chr8:19266685 CSGALNACT1 0.36 6.63 0.38 1.9e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg23048001 chr7:2026167 MAD1L1 0.41 5.24 0.31 3.25e-7 Schizophrenia, schizoaffective disorder or bipolar disorder; CESC cis rs12681366 0.734 rs3019146 chr8:95414106 C/T cg13257157 chr8:95487014 RAD54B 0.37 5.04 0.3 8.46e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs6493487 0.512 rs71471522 chr15:51153797 G/A cg02338191 chr15:51200825 AP4E1 0.51 5.12 0.3 5.98e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6570726 0.791 rs398408 chr6:145801020 G/A cg23711669 chr6:146136114 FBXO30 0.99 15.28 0.68 3.17e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg18305652 chr10:134549665 INPP5A 0.46 6.48 0.37 4.44e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg04317338 chr11:64019027 PLCB3 0.9 9.39 0.5 2.86e-18 Mean platelet volume; CESC cis rs10979 0.782 rs9390108 chr6:143892722 A/T cg25407410 chr6:143891975 LOC285740 -0.6 -8.92 -0.48 7.73e-17 Hypospadias; CESC cis rs7107174 0.892 rs12281104 chr11:78046940 T/C cg02023728 chr11:77925099 USP35 0.39 5.51 0.32 8.54e-8 Testicular germ cell tumor; CESC cis rs453301 0.686 rs4840389 chr8:8884503 G/C cg15556689 chr8:8085844 FLJ10661 -0.5 -6.12 -0.35 3.31e-9 Joint mobility (Beighton score); CESC cis rs6540559 0.673 rs17015361 chr1:210018901 C/G cg25204440 chr1:209979598 IRF6 0.53 5.27 0.31 2.8e-7 Cleft lip with or without cleft palate; CESC cis rs12155623 0.834 rs16939055 chr8:49824013 T/G cg00325661 chr8:49890786 NA 0.38 5.13 0.3 5.73e-7 Sudden cardiac arrest; CESC cis rs3747547 0.642 rs55836506 chr9:38071741 C/G cg13774184 chr9:37916125 SHB -0.68 -5.75 -0.33 2.43e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26979339 chr12:107168153 RIC8B -0.51 -6.7 -0.38 1.23e-10 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg17366294 chr4:99064904 C4orf37 0.59 8.41 0.46 2.53e-15 Colonoscopy-negative controls vs population controls; CESC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00928393 chr15:28358388 HERC2 0.52 6.08 0.35 4.06e-9 Response to antipsychotic treatment; CESC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg26354017 chr1:205819088 PM20D1 -0.51 -6.87 -0.39 4.67e-11 Menarche (age at onset); CESC cis rs3749237 1.000 rs2307021 chr3:49765483 C/G cg03060546 chr3:49711283 APEH 0.66 7.84 0.43 1.09e-13 Resting heart rate; CESC cis rs1728785 1.000 rs4783653 chr16:68562815 C/T cg02972257 chr16:68554789 NA -0.55 -6.45 -0.37 5.28e-10 Ulcerative colitis; CESC cis rs8067354 0.574 rs1295923 chr17:57960436 A/G cg02344993 chr17:57696989 CLTC 0.54 5.6 0.33 5.31e-8 Hemoglobin concentration; CESC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg02951883 chr7:2050386 MAD1L1 -0.49 -6.43 -0.37 5.78e-10 Bipolar disorder and schizophrenia; CESC cis rs897080 0.515 rs1067366 chr2:44655094 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.55 0.32 6.87e-8 Height; CESC cis rs11676348 0.846 rs7594532 chr2:219008000 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.45 -5.92 -0.34 9.68e-9 Ulcerative colitis; CESC cis rs3008870 0.755 rs2755271 chr1:67474977 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.62 8.14 0.45 1.57e-14 Lymphocyte percentage of white cells; CESC cis rs2625529 0.526 rs6494997 chr15:72560642 C/T cg16672083 chr15:72433130 SENP8 0.43 6.46 0.37 4.88e-10 Red blood cell count; CESC cis rs7651736 1.000 rs7651736 chr3:136760598 A/G cg04103450 chr3:136751342 NA 0.36 5.41 0.32 1.38e-7 Neuroticism; CESC cis rs1215050 0.740 rs783924 chr4:98969234 C/T cg05340658 chr4:99064831 C4orf37 -0.54 -7.32 -0.41 2.98e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7020830 0.898 rs308523 chr9:37338785 C/T cg14294708 chr9:37120828 ZCCHC7 1.11 19.69 0.77 8.52e-54 Schizophrenia; CESC cis rs9814567 1.000 rs4955485 chr3:134295843 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.44 -0.32 1.23e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs67072384 0.818 rs2291292 chr11:72467013 C/T cg04827223 chr11:72435913 ARAP1 -0.72 -7.41 -0.41 1.65e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg09509183 chr1:209979624 IRF6 0.55 5.67 0.33 3.74e-8 Cleft lip with or without cleft palate; CESC cis rs77956314 0.515 rs9804817 chr12:117440220 G/A cg25972092 chr12:117363249 FBXW8 -0.54 -5.89 -0.34 1.18e-8 Subcortical brain region volumes;Hippocampal volume; CESC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.736 rs12150322 chr17:80061582 T/G cg23985595 chr17:80112537 CCDC57 0.41 6.28 0.36 1.38e-9 Life satisfaction; CESC cis rs72945132 0.882 rs7929271 chr11:70165749 A/G cg14191688 chr11:70257035 CTTN 0.43 5.46 0.32 1.08e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15260365 chr11:67771606 UNC93B1 0.57 6.92 0.39 3.31e-11 Gut microbiome composition (summer); CESC cis rs7667 0.960 rs10917437 chr1:19710373 T/C cg15026089 chr1:19640712 PQLC2 -0.31 -5.18 -0.3 4.43e-7 Crohn's disease and psoriasis; CESC cis rs2180341 1.000 rs7756336 chr6:127650299 T/C cg27446573 chr6:127587934 RNF146 1.09 16.35 0.71 5.12e-42 Breast cancer; CESC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg25072359 chr17:41440525 NA 0.48 7.1 0.4 1.15e-11 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01737507 chr5:122372093 PPIC -0.46 -6.22 -0.36 1.89e-9 Ulcerative colitis; CESC cis rs7772486 0.790 rs11760 chr6:146205973 G/T cg05347473 chr6:146136440 FBXO30 0.55 7.05 0.4 1.52e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs7132746 0.620 rs61928910 chr12:86195948 A/G cg06215984 chr1:203258903 NA -0.56 -6.16 -0.35 2.64e-9 Lewy body disease; CESC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg18016565 chr1:150552671 MCL1 0.33 5.13 0.3 5.67e-7 Tonsillectomy; CESC cis rs2841277 0.676 rs10438246 chr14:105410183 T/C cg19901468 chr14:105411992 AHNAK2 -0.6 -8.78 -0.47 2.07e-16 Rheumatoid arthritis; CESC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.57 -0.32 6.25e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg06212747 chr3:49208901 KLHDC8B 0.73 9.61 0.51 5.84e-19 Parkinson's disease; CESC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs57221529 0.766 rs72703042 chr5:579269 C/T cg16447950 chr5:562315 NA -0.62 -6.54 -0.37 3.2e-10 Lung disease severity in cystic fibrosis; CESC cis rs3741151 0.773 rs79994237 chr11:73147974 T/C cg17517138 chr11:73019481 ARHGEF17 1.0 7.39 0.41 1.91e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 10.03 0.52 2.83e-20 Platelet count; CESC cis rs1499614 1.000 rs60326618 chr7:66166358 G/A cg18252515 chr7:66147081 NA -1.42 -14.62 -0.67 6.69e-36 Gout; CESC cis rs662064 0.889 rs1188526 chr1:10549848 G/C cg20482658 chr1:10539492 PEX14 -0.39 -8.0 -0.44 3.93e-14 Asthma; CESC trans rs8073060 0.586 rs225298 chr17:33923946 T/G cg19694781 chr19:47549865 TMEM160 -0.71 -6.97 -0.39 2.49e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs919433 0.963 rs4850787 chr2:198181750 G/A cg10820045 chr2:198174542 NA -0.4 -5.64 -0.33 4.39e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs12956009 0.559 rs1893787 chr18:44856030 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 5.86 0.34 1.37e-8 Educational attainment (years of education); CESC trans rs3780486 0.957 rs10971434 chr9:33168891 C/A cg04842962 chr6:43655489 MRPS18A 0.86 12.59 0.61 8.51e-29 IgG glycosylation; CESC cis rs9487051 0.676 rs6568567 chr6:109596993 A/G cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC cis rs1348850 0.526 rs4893829 chr2:178399810 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.65 -6.01 -0.35 6.12e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg09035930 chr12:129282057 SLC15A4 0.79 11.2 0.57 4.35e-24 Systemic lupus erythematosus; CESC cis rs477692 1.000 rs473073 chr10:131429646 G/T cg05714579 chr10:131428358 MGMT 0.51 6.92 0.39 3.31e-11 Response to temozolomide; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03705947 chr1:68152081 GADD45A 0.5 6.94 0.39 3.09e-11 Systemic lupus erythematosus; CESC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg05368731 chr17:41323189 NBR1 0.72 8.21 0.45 9.49e-15 Menopause (age at onset); CESC cis rs644148 0.803 rs2686771 chr19:44999494 T/C cg15540054 chr19:45004280 ZNF180 -0.72 -8.44 -0.46 2.12e-15 Personality dimensions; CESC cis rs7592578 0.679 rs4287794 chr2:191327147 T/C cg27211696 chr2:191398769 TMEM194B -0.53 -5.38 -0.31 1.63e-7 Diastolic blood pressure; CESC trans rs9858542 0.951 rs1800668 chr3:49395757 G/A cg21659725 chr3:3221576 CRBN -0.55 -6.53 -0.37 3.38e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs61931739 0.500 rs11513287 chr12:34584351 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.92 0.56 3.54e-23 Morning vs. evening chronotype; CESC cis rs3015497 0.646 rs2934693 chr14:51101641 C/T cg26011998 chr14:51135199 SAV1 -0.58 -6.46 -0.37 5.06e-10 Mean platelet volume; CESC cis rs2404602 0.692 rs72738889 chr15:76992063 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.58 -0.32 6.05e-8 Blood metabolite levels; CESC cis rs9325144 0.556 rs34565156 chr12:39028239 G/A cg26384229 chr12:38710491 ALG10B -0.56 -7.83 -0.43 1.16e-13 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22461615 chr4:83821917 THAP9 0.61 7.48 0.42 1.11e-12 Gut microbiome composition (summer); CESC cis rs12765878 1.000 rs2067832 chr10:105643134 G/A cg24587175 chr10:105670608 OBFC1 0.31 5.07 0.3 7.48e-7 Coronary artery disease; CESC cis rs3105593 0.965 rs12442721 chr15:50910813 C/T cg08437265 chr15:50716283 USP8 0.4 5.13 0.3 5.69e-7 QT interval; CESC trans rs9329221 0.537 rs6983332 chr8:9977918 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.03 -0.35 5.58e-9 Neuroticism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02438591 chr16:2205559 TRAF7;SNORD60 -0.47 -6.03 -0.35 5.37e-9 Ulcerative colitis; CESC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.65 0.47 4.88e-16 Menopause (age at onset); CESC cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg18351406 chr4:77819688 ANKRD56 -0.49 -6.09 -0.35 3.98e-9 Emphysema distribution in smoking; CESC trans rs11098499 0.739 rs6534130 chr4:120131339 A/T cg25214090 chr10:38739885 LOC399744 -0.55 -7.2 -0.4 6.35e-12 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12867853 chr22:44351301 SAMM50 0.56 6.42 0.37 6.18e-10 Gut microbiome composition (summer); CESC trans rs1814175 0.817 rs10769617 chr11:49810421 G/A cg03929089 chr4:120376271 NA -0.91 -15.29 -0.68 2.8900000000000003e-38 Height; CESC cis rs6424115 0.708 rs12748109 chr1:24181177 C/T cg15997130 chr1:24165203 NA -0.4 -5.04 -0.3 8.83e-7 Immature fraction of reticulocytes; CESC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg02951883 chr7:2050386 MAD1L1 -0.4 -5.13 -0.3 5.68e-7 Schizophrenia; CESC cis rs9790314 1.000 rs1478565 chr3:161027464 C/T cg03342759 chr3:160939853 NMD3 -0.45 -5.85 -0.34 1.41e-8 Morning vs. evening chronotype; CESC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg24531977 chr5:56204891 C5orf35 -0.87 -10.87 -0.56 5.43e-23 Initial pursuit acceleration; CESC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.71 0.33 3.01e-8 Major depressive disorder; CESC cis rs6062302 0.522 rs13038448 chr20:62218453 C/T cg06363034 chr20:62225388 GMEB2 -0.52 -6.54 -0.37 3.07e-10 Glioblastoma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03000844 chr2:242641386 ING5 -0.4 -6.04 -0.35 5.1e-9 Gambling; CESC cis rs977987 0.806 rs4993970 chr16:75411619 G/A cg03315344 chr16:75512273 CHST6 0.4 5.74 0.33 2.65e-8 Dupuytren's disease; CESC cis rs2297440 0.530 rs34533955 chr20:62233020 A/C cg06363034 chr20:62225388 GMEB2 -0.51 -6.58 -0.37 2.52e-10 Glioma;Non-glioblastoma glioma;Glioblastoma; CESC cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.97e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7937682 0.632 rs14133 chr11:111782697 C/G cg22437258 chr11:111473054 SIK2 -0.49 -5.51 -0.32 8.46e-8 Primary sclerosing cholangitis; CESC cis rs5758659 0.623 rs133328 chr22:42408079 T/C cg15557168 chr22:42548783 NA -0.45 -6.69 -0.38 1.33e-10 Cognitive function; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24110768 chr12:58159478 CYP27B1 -0.48 -6.29 -0.36 1.28e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg17221315 chr6:27791827 HIST1H4J 0.44 5.84 0.34 1.51e-8 Cardiac Troponin-T levels; CESC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg14393609 chr7:65229607 NA -0.47 -6.31 -0.36 1.16e-9 Aortic root size; CESC trans rs2764766 0.755 rs245314 chr5:127164455 C/T cg15764593 chr10:829463 NA 0.39 6.15 0.35 2.82e-9 Schizophrenia; CESC cis rs12155623 0.603 rs2203065 chr8:49881987 A/G cg22283653 chr8:49824208 NA -0.34 -5.14 -0.3 5.46e-7 Sudden cardiac arrest; CESC cis rs11077998 0.967 rs4789796 chr17:80521135 T/C cg10255544 chr17:80519551 FOXK2 0.54 8.68 0.47 4.11e-16 Reticulocyte fraction of red cells; CESC cis rs7918232 0.941 rs1775350 chr10:27441973 C/T cg14442939 chr10:27389572 ANKRD26 -0.67 -6.45 -0.37 5.34e-10 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16786661 chr2:234160315 ATG16L1 0.62 7.34 0.41 2.69e-12 Gut microbiome composition (summer); CESC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg00684032 chr4:1343700 KIAA1530 0.4 5.56 0.32 6.51e-8 Obesity-related traits; CESC cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg14784868 chr12:69753453 YEATS4 0.6 8.56 0.47 9.5e-16 Blood protein levels; CESC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg08888203 chr3:10149979 C3orf24 0.5 6.33 0.36 1.05e-9 Alzheimer's disease; CESC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg26119090 chr2:26468346 HADHA;HADHB 0.8 8.59 0.47 7.61e-16 Gut microbiome composition (summer); CESC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg01341218 chr17:43662625 NA 0.92 10.51 0.54 8.08e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg05347473 chr6:146136440 FBXO30 0.59 7.59 0.42 5.36e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs1499614 1.000 rs2707840 chr7:66158015 C/T cg13147721 chr7:65941812 NA -0.94 -8.81 -0.48 1.69e-16 Gout; CESC cis rs8018808 1.000 rs12432247 chr14:77856321 T/C cg20045696 chr14:77926864 AHSA1 -0.38 -5.18 -0.3 4.46e-7 Myeloid white cell count; CESC cis rs4253772 0.550 rs738444 chr22:46721088 C/T cg18190219 chr22:46762943 CELSR1 -0.44 -5.6 -0.33 5.38e-8 LDL cholesterol;Cholesterol, total; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09338170 chr1:100436032 SLC35A3 0.45 6.44 0.37 5.68e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4319547 0.774 rs7307233 chr12:123124301 C/G cg05707623 chr12:122985044 ZCCHC8 -0.51 -6.12 -0.35 3.43e-9 Body mass index; CESC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg02725872 chr8:58115012 NA -0.35 -5.12 -0.3 5.93e-7 Developmental language disorder (linguistic errors); CESC cis rs10779751 1.000 rs4845856 chr1:11274547 T/C cg08854313 chr1:11322531 MTOR 0.91 14.23 0.66 1.61e-34 Body mass index; CESC cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg18180107 chr4:99064573 C4orf37 0.39 5.09 0.3 6.72e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs10852933 chr17:37698194 G/T cg07936489 chr17:37558343 FBXL20 -0.8 -11.62 -0.58 1.73e-25 Glomerular filtration rate (creatinine); CESC cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg11812906 chr14:75593930 NEK9 -0.86 -14.17 -0.66 2.67e-34 Height; CESC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg12311346 chr5:56204834 C5orf35 -0.72 -8.86 -0.48 1.15e-16 Initial pursuit acceleration; CESC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg04166393 chr7:2884313 GNA12 0.6 7.83 0.43 1.14e-13 Height; CESC cis rs6540559 0.673 rs7525951 chr1:210018306 C/T cg21951975 chr1:209979733 IRF6 -0.55 -6.65 -0.38 1.64e-10 Cleft lip with or without cleft palate; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17959943 chr7:135194977 CNOT4 -0.44 -6.31 -0.36 1.14e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs854765 0.583 rs8065563 chr17:17782404 A/G cg09796270 chr17:17721594 SREBF1 0.47 6.5 0.37 3.87e-10 Total body bone mineral density; CESC cis rs870825 0.655 rs12502771 chr4:185635834 T/C cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs1023500 0.505 rs134888 chr22:42674281 C/T cg15557168 chr22:42548783 NA -0.45 -7.01 -0.4 1.96e-11 Schizophrenia; CESC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg04944784 chr2:26401820 FAM59B -0.65 -7.4 -0.41 1.8e-12 Gut microbiome composition (summer); CESC cis rs7692995 1.000 rs11936915 chr4:17948497 T/C cg08925142 chr4:18023851 LCORL -0.44 -5.1 -0.3 6.36e-7 Height; CESC cis rs1729951 0.575 rs1682356 chr3:136692037 T/C cg25687071 chr3:136751404 NA 0.4 5.26 0.31 2.93e-7 Neuroticism; CESC cis rs2204008 0.599 rs2320526 chr12:38220405 T/A cg13010199 chr12:38710504 ALG10B 0.48 5.88 0.34 1.25e-8 Bladder cancer; CESC cis rs6061231 0.798 rs2427308 chr20:60969451 C/T cg24112000 chr20:60950667 NA -0.6 -7.28 -0.41 3.89e-12 Colorectal cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16965475 chr1:52870119 ORC1L;PRPF38A -0.53 -6.3 -0.36 1.2e-9 Ulcerative colitis; CESC cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg25019033 chr10:957182 NA -0.64 -7.9 -0.44 7.56e-14 Eosinophil percentage of granulocytes; CESC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.6 0.47 6.99e-16 Menopause (age at onset); CESC cis rs796364 0.715 rs11688872 chr2:201052418 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.77 -6.51 -0.37 3.76e-10 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07116015 chr17:27046591 RAB34;SNORD42B;RPL23A -0.52 -6.51 -0.37 3.72e-10 Ulcerative colitis; CESC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.19 -0.4 6.61e-12 Personality dimensions; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07339812 chr16:25268887 ZKSCAN2 -0.51 -6.42 -0.37 6.26e-10 Asthma; CESC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg09060608 chr5:178986726 RUFY1 -0.51 -7.52 -0.42 8.3e-13 Lung cancer; CESC cis rs78456975 0.527 rs10206020 chr2:1557927 A/G cg26248373 chr2:1572462 NA -0.55 -6.54 -0.37 3.24e-10 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.53 -6.98 -0.39 2.35e-11 Menarche (age at onset); CESC cis rs698833 0.926 rs1065786 chr2:44660616 G/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.45 -5.89 -0.34 1.18e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs651907 0.557 rs11914318 chr3:101453858 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.88 0.34 1.22e-8 Colorectal cancer; CESC cis rs2795502 1.000 rs2744092 chr10:43339343 T/C cg27426351 chr10:43362370 NA -0.45 -5.5 -0.32 8.91e-8 Blood protein levels; CESC cis rs61931739 0.749 rs11053093 chr12:34231095 A/G cg19457237 chr12:34500585 NA -0.38 -5.45 -0.32 1.15e-7 Morning vs. evening chronotype; CESC cis rs6500602 1.000 rs6500602 chr16:4497451 T/C cg08645402 chr16:4508243 NA 0.44 6.65 0.38 1.71e-10 Schizophrenia; CESC cis rs3126085 0.935 rs7533529 chr1:152176871 T/C cg03465714 chr1:152285911 FLG -0.46 -5.59 -0.32 5.7e-8 Atopic dermatitis; CESC cis rs7107174 0.792 rs10899488 chr11:78088754 A/G cg02023728 chr11:77925099 USP35 0.44 5.85 0.34 1.48e-8 Testicular germ cell tumor; CESC trans rs17685 0.712 rs4732578 chr7:75721532 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 12.47 0.61 2.13e-28 Coffee consumption;Coffee consumption (cups per day); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09665691 chr3:47563885 NA 0.49 6.13 0.35 3.26e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs62103177 0.810 rs62103192 chr18:77629050 A/T cg12964065 chr18:77638022 KCNG2 0.58 5.46 0.32 1.07e-7 Opioid sensitivity; CESC cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg15813090 chr5:442598 EXOC3;C5orf55 0.36 5.74 0.33 2.53e-8 Cystic fibrosis severity; CESC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.31e-9 Developmental language disorder (linguistic errors); CESC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg22800045 chr5:56110881 MAP3K1 0.63 7.94 0.44 5.83e-14 Type 2 diabetes; CESC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg02353165 chr6:42928485 GNMT 0.86 14.79 0.67 1.73e-36 Alzheimer's disease in APOE e4+ carriers; CESC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg11965913 chr1:205819406 PM20D1 0.64 10.52 0.54 7.26e-22 Monocyte percentage of white cells; CESC cis rs8016982 0.962 rs8007841 chr14:81647878 C/T cg01989461 chr14:81687754 GTF2A1 -0.48 -6.15 -0.35 2.9e-9 Schizophrenia; CESC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Parkinson's disease; CESC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg18305652 chr10:134549665 INPP5A 0.48 7.57 0.42 6.08e-13 Migraine; CESC cis rs10208940 0.920 rs13400155 chr2:68723636 G/A cg12452813 chr2:68675892 NA 0.52 5.24 0.31 3.26e-7 Urate levels in lean individuals; CESC trans rs9929218 0.953 rs12930910 chr16:68762520 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -9.88 -0.52 8.58e-20 Colorectal cancer; CESC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg06877462 chr1:205807181 PM20D1 0.39 5.84 0.34 1.51e-8 Menarche (age at onset); CESC cis rs10484885 0.763 rs56401039 chr6:90522486 C/T cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.12 -0.4 1.04e-11 QRS interval (sulfonylurea treatment interaction); CESC cis rs12983728 1.000 rs12983728 chr19:58671267 G/A cg24884572 chr19:58661833 ZNF329 0.55 5.26 0.31 2.92e-7 Cholesterol, total; CESC cis rs7296418 0.754 rs1619283 chr12:123717362 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.05 -0.3 8.18e-7 Platelet count; CESC cis rs3087591 0.960 rs4795587 chr17:29587917 A/C cg24425628 chr17:29625626 OMG;NF1 -0.47 -5.73 -0.33 2.66e-8 Hip circumference; CESC cis rs698833 0.506 rs4952705 chr2:44499867 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.13 0.3 5.66e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs791888 0.965 rs791875 chr10:89406088 C/T cg13926569 chr10:89418898 PAPSS2 -0.4 -5.43 -0.32 1.3e-7 Magnesium levels; CESC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg04518342 chr5:131593106 PDLIM4 0.4 6.01 0.35 6.19e-9 Breast cancer; CESC cis rs77216612 0.835 rs10845621 chr12:12887977 C/T cg09462578 chr12:12878428 APOLD1 -0.98 -14.75 -0.67 2.29e-36 Lymphocyte counts; CESC cis rs11122272 0.735 rs2572253 chr1:231512768 C/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13078969 chr12:1799970 ADIPOR2 0.39 6.04 0.35 5.06e-9 Gambling; CESC cis rs916888 0.773 rs199443 chr17:44819565 C/T cg15921436 chr17:44337874 NA 0.74 8.12 0.45 1.79e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6499255 0.951 rs689455 chr16:69761661 T/G cg15192750 chr16:69999425 NA 0.51 5.91 0.34 1.07e-8 IgE levels; CESC cis rs7246657 0.943 rs7259968 chr19:37811854 T/C cg23950597 chr19:37808831 NA -0.57 -6.33 -0.36 1.06e-9 Coronary artery calcification; CESC cis rs4835473 0.897 rs1553070 chr4:144637134 C/T cg25736465 chr4:144833511 NA 0.39 6.12 0.35 3.39e-9 Immature fraction of reticulocytes; CESC cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.48 8.36 0.46 3.54e-15 Monocyte percentage of white cells; CESC cis rs1124376 1.000 rs17006623 chr3:20161043 G/T cg05072819 chr3:20081367 KAT2B 0.49 5.35 0.31 1.93e-7 Bipolar disorder and schizophrenia; CESC cis rs921968 0.508 rs72965103 chr2:219312469 T/C cg02176678 chr2:219576539 TTLL4 -0.52 -9.12 -0.49 1.96e-17 Mean corpuscular hemoglobin concentration; CESC cis rs4654899 0.743 rs61781069 chr1:21130735 T/C cg05370193 chr1:21551575 ECE1 0.41 5.87 0.34 1.28e-8 Superior frontal gyrus grey matter volume; CESC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg17376030 chr22:41985996 PMM1 0.67 7.19 0.4 6.44e-12 Vitiligo; CESC cis rs9837602 1.000 rs9851645 chr3:99767409 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.56 0.42 6.43e-13 Breast cancer; CESC cis rs4835473 0.864 rs7681559 chr4:144616401 T/C cg25736465 chr4:144833511 NA -0.42 -6.22 -0.36 1.95e-9 Immature fraction of reticulocytes; CESC cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.626 rs162389 chr21:44936227 T/C cg01579765 chr21:45077557 HSF2BP -0.49 -8.76 -0.47 2.41e-16 Mean corpuscular volume; CESC cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs17376456 0.825 rs74825443 chr5:93254973 T/C cg25358565 chr5:93447407 FAM172A 1.13 10.44 0.54 1.31e-21 Diabetic retinopathy; CESC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg22442454 chr1:209979470 IRF6 0.45 5.34 0.31 2.02e-7 Cleft lip with or without cleft palate; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg14344315 chr15:31733445 NA 0.43 6.01 0.35 6.11e-9 Thyroid stimulating hormone; CESC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -7.94 -0.44 5.73e-14 Personality dimensions; CESC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg16145915 chr7:1198662 ZFAND2A -0.49 -7.1 -0.4 1.17e-11 Longevity;Endometriosis; CESC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg18099408 chr3:52552593 STAB1 -0.32 -5.19 -0.3 4.2e-7 Bipolar disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12525736 chr1:228269915 ARF1 -0.49 -6.04 -0.35 5.16e-9 Ulcerative colitis; CESC cis rs4474465 0.850 rs10793328 chr11:78256868 A/G cg02023728 chr11:77925099 USP35 -0.38 -5.04 -0.3 8.62e-7 Alzheimer's disease (survival time); CESC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.82 -0.34 1.68e-8 Total body bone mineral density; CESC cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg25019033 chr10:957182 NA -0.65 -8.19 -0.45 1.08e-14 Eosinophil percentage of granulocytes; CESC trans rs1814175 0.754 rs28593359 chr11:50042357 C/T cg03929089 chr4:120376271 NA -0.94 -15.73 -0.69 7.69e-40 Height; CESC cis rs796364 0.806 rs79156935 chr2:200913822 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg20891283 chr12:69753455 YEATS4 0.87 14.05 0.65 6.94e-34 Blood protein levels; CESC trans rs11039798 0.588 rs11039781 chr11:48523085 T/G cg15704280 chr7:45808275 SEPT13 0.65 6.56 0.37 2.84e-10 Axial length; CESC cis rs2050392 0.687 rs608693 chr10:30734971 G/A cg25182066 chr10:30743637 MAP3K8 -0.48 -6.44 -0.37 5.64e-10 Inflammatory bowel disease; CESC cis rs2760061 0.659 rs708107 chr1:228189495 C/T cg18477163 chr1:228402036 OBSCN 0.3 5.19 0.3 4.25e-7 Diastolic blood pressure; CESC cis rs9303401 0.538 rs12603174 chr17:56489279 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.9 11.03 0.56 1.6e-23 Cognitive test performance; CESC cis rs7762018 1.000 rs73242910 chr6:170114670 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.52 5.27 0.31 2.86e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7264396 0.790 rs6060530 chr20:34227663 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -10.31 -0.54 3.47e-21 Total cholesterol levels; CESC cis rs7666738 0.830 rs991168 chr4:98928293 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs73206853 0.841 rs73191819 chr12:110920182 C/T cg12870014 chr12:110450643 ANKRD13A 0.63 5.22 0.31 3.56e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs477692 0.569 rs1762418 chr10:131303353 G/A cg05714579 chr10:131428358 MGMT 0.39 5.26 0.31 2.9e-7 Response to temozolomide; CESC trans rs3780486 0.522 rs10217770 chr9:33146393 C/A cg04842962 chr6:43655489 MRPS18A 0.66 9.82 0.52 1.33e-19 IgG glycosylation; CESC trans rs804280 0.542 rs35647515 chr8:11791629 C/T cg15556689 chr8:8085844 FLJ10661 0.51 6.36 0.36 8.66e-10 Myopia (pathological); CESC cis rs208520 0.690 rs12189780 chr6:66759619 G/A cg07460842 chr6:66804631 NA 0.96 12.78 0.62 1.92e-29 Exhaled nitric oxide output; CESC cis rs11122272 0.735 rs2011357 chr1:231480208 A/G cg06096015 chr1:231504339 EGLN1 0.44 6.29 0.36 1.31e-9 Hemoglobin concentration; CESC cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg22633769 chr20:60982531 CABLES2 0.5 5.12 0.3 5.95e-7 Colorectal cancer; CESC cis rs116095464 0.510 rs73016876 chr5:244475 T/C cg22857025 chr5:266934 NA -1.26 -17.43 -0.73 7.56e-46 Breast cancer; CESC cis rs3820068 0.603 rs7529759 chr1:15977877 A/G cg13390004 chr1:15929781 NA 0.36 5.68 0.33 3.52e-8 Systolic blood pressure; CESC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.44 5.89 0.34 1.16e-8 Menopause (age at onset); CESC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.78 0.59 4.93e-26 Alzheimer's disease; CESC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg05368731 chr17:41323189 NBR1 0.61 8.28 0.45 6.11e-15 Menopause (age at onset); CESC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg08888203 chr3:10149979 C3orf24 0.52 6.65 0.38 1.63e-10 Alzheimer's disease; CESC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg05552183 chr6:42928497 GNMT 0.78 12.94 0.62 5.31e-30 Alzheimer's disease in APOE e4+ carriers; CESC cis rs727505 1.000 rs12111865 chr7:124498035 G/A cg23710748 chr7:124431027 NA -0.4 -6.47 -0.37 4.6e-10 Lewy body disease; CESC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 12.44 0.61 2.65e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9527 0.615 rs11191489 chr10:104740568 C/A cg08650961 chr10:104748594 CNNM2 0.32 5.08 0.3 6.98e-7 Arsenic metabolism; CESC cis rs11264213 0.901 rs72661641 chr1:36448130 A/G cg27506609 chr1:36549197 TEKT2 0.67 5.56 0.32 6.59e-8 Schizophrenia; CESC cis rs7107174 1.000 rs1485483 chr11:77930138 T/C cg02023728 chr11:77925099 USP35 0.5 6.18 0.36 2.38e-9 Testicular germ cell tumor; CESC cis rs3936840 0.861 rs1044502 chr14:102965897 G/A cg18135206 chr14:102964638 TECPR2 0.41 5.46 0.32 1.11e-7 Plateletcrit; CESC cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg10578991 chr7:12443926 VWDE -0.43 -5.55 -0.32 6.81e-8 Coronary artery disease; CESC cis rs7542091 0.669 rs7540534 chr1:210044824 A/T cg23283495 chr1:209979779 IRF6 0.35 5.8 0.34 1.84e-8 Monobrow; CESC cis rs1153858 1.000 rs4775906 chr15:45638294 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs2228479 0.681 rs11642428 chr16:89971909 A/T cg00800038 chr16:89945340 TCF25 -0.58 -6.27 -0.36 1.44e-9 Skin colour saturation; CESC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg05025164 chr4:1340916 KIAA1530 0.58 7.94 0.44 5.63e-14 Longevity; CESC cis rs9902453 0.845 rs3115099 chr17:28019293 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.53 0.46 1.15e-15 Coffee consumption (cups per day); CESC cis rs870825 0.616 rs6817521 chr4:185649827 A/G cg04058563 chr4:185651563 MLF1IP -0.67 -7.14 -0.4 8.9e-12 Blood protein levels; CESC cis rs1577917 1.000 rs12201880 chr6:86627007 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.33 2.14e-8 Response to antipsychotic treatment; CESC cis rs3540 0.533 rs2601197 chr15:90940059 C/A cg22089800 chr15:90895588 ZNF774 0.63 8.72 0.47 3.02e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9287719 0.967 rs12995159 chr2:10753323 C/T cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs12780046 0.536 rs7914788 chr10:101063589 C/T cg27143070 chr10:101087766 CNNM1 -0.37 -5.44 -0.32 1.21e-7 Non-glioblastoma glioma; CESC cis rs17376456 0.542 rs2084916 chr5:93194961 A/T cg25358565 chr5:93447407 FAM172A -0.7 -7.43 -0.42 1.45e-12 Diabetic retinopathy; CESC cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.47 0.46 1.72e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6977660 0.652 rs58559474 chr7:19751569 C/T cg07541023 chr7:19748670 TWISTNB 0.82 7.27 0.41 4.17e-12 Thyroid stimulating hormone; CESC cis rs10129255 0.957 rs8022165 chr14:107189919 C/G cg07958169 chr14:107095056 NA -0.4 -5.54 -0.32 7.3e-8 Kawasaki disease; CESC cis rs2297440 0.527 rs4809318 chr20:62264760 G/A cg09650180 chr20:62225654 GMEB2 -0.81 -9.1 -0.49 2.31e-17 Glioma;Non-glioblastoma glioma;Glioblastoma; CESC cis rs703842 1.000 rs10877013 chr12:58165085 C/T cg18357645 chr12:58087776 OS9 -0.38 -5.42 -0.32 1.34e-7 Multiple sclerosis; CESC trans rs4927850 1.000 rs7630875 chr3:195753766 A/G cg16724585 chr3:197361211 NA -0.55 -6.97 -0.39 2.54e-11 Pancreatic cancer; CESC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg09074113 chr2:20870087 GDF7 -0.42 -6.87 -0.39 4.56e-11 Abdominal aortic aneurysm; CESC cis rs1983891 0.706 rs9381084 chr6:41570350 C/T cg20194872 chr6:41519635 FOXP4 0.46 6.56 0.37 2.75e-10 Prostate cancer; CESC cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg05347473 chr6:146136440 FBXO30 0.58 7.57 0.42 6.18e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg26314531 chr2:26401878 FAM59B 0.69 7.36 0.41 2.27e-12 Gut microbiome composition (summer); CESC cis rs10751667 0.666 rs10902248 chr11:957742 A/G cg06064525 chr11:970664 AP2A2 -0.48 -9.52 -0.5 1.15e-18 Alzheimer's disease (late onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19818298 chr14:21905552 CHD8 -0.43 -6.23 -0.36 1.8e-9 Gut microbiota (bacterial taxa); CESC cis rs524281 0.648 rs4565902 chr11:65810045 T/G cg14036092 chr11:66035641 RAB1B -0.57 -5.42 -0.32 1.37e-7 Electroencephalogram traits; CESC cis rs11203032 0.831 rs10887929 chr10:90948864 T/C cg16672925 chr10:90967113 CH25H 0.72 7.16 0.4 7.78e-12 Heart failure; CESC cis rs6693567 0.516 rs3850844 chr1:150413940 G/T cg09579323 chr1:150459698 TARS2 0.48 6.0 0.35 6.34e-9 Migraine; CESC cis rs12956009 0.583 rs16952069 chr18:44904220 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 6.11 0.35 3.5e-9 Educational attainment (years of education); CESC cis rs4901869 0.902 rs2162491 chr14:59296247 C/T cg02291164 chr14:59296302 NA 0.46 8.07 0.44 2.41e-14 Panic disorder; CESC cis rs7592578 0.723 rs4371384 chr2:191430741 A/G cg27211696 chr2:191398769 TMEM194B 0.64 5.81 0.34 1.81e-8 Diastolic blood pressure; CESC cis rs2439831 0.867 rs2278860 chr15:43659046 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.85 -12.75 -0.62 2.26e-29 Lung cancer in ever smokers; CESC cis rs2629540 0.731 rs11245341 chr10:126408777 G/C cg08799069 chr10:126477246 METTL10 0.6 7.51 0.42 8.93e-13 Cocaine dependence; CESC cis rs57221529 0.766 rs12522303 chr5:555564 A/C cg16447950 chr5:562315 NA -0.7 -7.76 -0.43 1.9e-13 Lung disease severity in cystic fibrosis; CESC cis rs2845885 0.793 rs56241103 chr11:63882364 C/T cg26318627 chr11:63887540 MACROD1 -0.46 -5.46 -0.32 1.1e-7 Body mass index; CESC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs4466137 0.951 rs336958 chr5:82973396 A/G cg16102102 chr5:83017553 HAPLN1 -0.4 -5.44 -0.32 1.18e-7 Prostate cancer; CESC cis rs4820539 0.902 rs9612237 chr22:23472954 T/C cg14186256 chr22:23484241 RTDR1 0.81 14.46 0.66 2.43e-35 Bone mineral density; CESC cis rs9325144 0.600 rs61931871 chr12:38829889 G/A cg26384229 chr12:38710491 ALG10B -0.57 -7.94 -0.44 5.9e-14 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08426800 chr19:1229184 NA 0.46 6.07 0.35 4.49e-9 Fibrinogen levels; CESC cis rs896854 0.517 rs896851 chr8:95950251 T/C cg13393036 chr8:95962371 TP53INP1 -0.44 -7.83 -0.43 1.21e-13 Type 2 diabetes; CESC cis rs7100689 0.646 rs1572819 chr10:82112488 A/G cg00277334 chr10:82204260 NA -0.61 -8.01 -0.44 3.56e-14 Post bronchodilator FEV1; CESC cis rs6460942 0.597 rs35317839 chr7:12524397 C/A cg10578991 chr7:12443926 VWDE -0.49 -5.13 -0.3 5.63e-7 Coronary artery disease; CESC cis rs1316952 0.831 rs77732168 chr12:124392120 G/C cg00084347 chr12:124393913 DNAH10 0.41 5.68 0.33 3.56e-8 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs711245 0.573 rs3770796 chr2:36799515 T/C cg09467607 chr2:36825704 FEZ2 0.57 9.98 0.52 3.98e-20 Height; CESC cis rs9300255 0.544 rs1716157 chr12:123670473 T/C cg00376283 chr12:123451042 ABCB9 0.71 8.71 0.47 3.27e-16 Neutrophil percentage of white cells; CESC cis rs11696501 0.739 rs6104257 chr20:44262100 G/T cg11783356 chr20:44313418 WFDC10B -0.34 -5.29 -0.31 2.54e-7 Brain structure; CESC cis rs77106637 0.932 rs17244499 chr11:72629946 C/T cg04827223 chr11:72435913 ARAP1 0.52 5.49 0.32 9.64e-8 Type 2 diabetes; CESC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg18099408 chr3:52552593 STAB1 -0.32 -5.2 -0.3 4.03e-7 Bipolar disorder; CESC cis rs922182 0.633 rs4776698 chr15:64267534 C/A cg24729988 chr15:64271149 DAPK2 -0.48 -6.82 -0.39 6.32e-11 Blood protein levels; CESC cis rs2404602 0.536 rs11072599 chr15:76774508 T/C cg22467129 chr15:76604101 ETFA -0.38 -5.82 -0.34 1.69e-8 Blood metabolite levels; CESC cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -5.89 -0.34 1.18e-8 Total body bone mineral density; CESC cis rs2730245 0.592 rs2657385 chr7:158649373 A/G cg24397884 chr7:158709396 WDR60 0.67 9.71 0.51 2.83e-19 Height; CESC cis rs6543140 1.000 rs6543140 chr2:103074274 G/T cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs6502050 0.799 rs7212023 chr17:80170354 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.67 -0.38 1.48e-10 Life satisfaction; CESC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg08470875 chr2:26401718 FAM59B 0.69 6.74 0.38 1.01e-10 Gut microbiome composition (summer); CESC cis rs2439831 0.850 rs3825783 chr15:44102309 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.64 5.81 0.34 1.77e-8 Lung cancer in ever smokers; CESC cis rs4820294 0.926 rs62236671 chr22:38069305 G/A cg21798802 chr22:38057573 PDXP 0.46 7.89 0.44 8.23e-14 Fat distribution (HIV); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg02357389 chr12:82752162 CCDC59;C12orf26 -0.45 -6.12 -0.35 3.39e-9 Thyroid stimulating hormone; CESC cis rs6547741 0.874 rs28381983 chr2:27804432 T/C cg27432699 chr2:27873401 GPN1 0.49 6.63 0.38 1.89e-10 Oral cavity cancer; CESC cis rs892961 0.932 rs11657725 chr17:75405501 G/C cg05865280 chr17:75406074 SEPT9 0.59 10.95 0.56 2.82e-23 Airflow obstruction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13656025 chr17:7744978 KDM6B 0.63 7.48 0.42 1.1e-12 Gut microbiome composition (summer); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg26085966 chr14:64319812 SYNE2 0.53 6.73 0.38 1.06e-10 Breast cancer;Type 2 diabetes; CESC cis rs72945132 0.882 rs6592522 chr11:70128271 G/A cg00319359 chr11:70116639 PPFIA1 0.79 7.55 0.42 6.95e-13 Coronary artery disease; CESC trans rs12659622 0.790 rs10454921 chr5:15676169 C/T cg22457238 chr19:58570995 ZNF135 -0.51 -6.01 -0.35 6.11e-9 Obesity-related traits; CESC cis rs12220238 1.000 rs11000894 chr10:75906598 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.23 0.36 1.87e-9 Soluble interleukin-2 receptor subunit alpha; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22234897 chr17:7826291 KCNAB3 0.44 6.1 0.35 3.84e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs208520 0.770 rs2224422 chr6:66883993 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.49 -0.58 4.62e-25 Exhaled nitric oxide output; CESC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg03188948 chr7:1209495 NA 0.57 6.45 0.37 5.21e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11048434 0.736 rs933462 chr12:9103665 T/G cg04155231 chr12:9217510 LOC144571 0.32 5.06 0.3 7.79e-7 Sjögren's syndrome; CESC cis rs6570726 0.846 rs973856 chr6:145781916 C/T cg05347473 chr6:146136440 FBXO30 -0.45 -6.02 -0.35 5.81e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.82 0.34 1.74e-8 Colonoscopy-negative controls vs population controls; CESC cis rs10733682 0.659 rs867560 chr9:129465233 C/G cg00232160 chr9:129468157 NA -0.37 -5.81 -0.34 1.78e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.49 -5.2 -0.3 4.06e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1881797 1.000 rs12061460 chr1:247686787 G/A cg18198730 chr1:247681584 NA 0.59 7.76 0.43 1.84e-13 Acute lymphoblastic leukemia (childhood); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg20685215 chr8:10696571 PINX1 -0.45 -6.04 -0.35 5.12e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6940638 0.688 rs1028308 chr6:27129757 G/A cg12292205 chr6:26970375 C6orf41 -0.4 -5.43 -0.32 1.3e-7 Intelligence (multi-trait analysis); CESC cis rs4588572 0.644 rs10805920 chr5:77698222 G/A cg11547950 chr5:77652471 NA -0.4 -5.69 -0.33 3.33e-8 Triglycerides; CESC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg12373951 chr3:133503437 NA 0.42 6.09 0.35 4.03e-9 Iron status biomarkers; CESC cis rs2070433 0.851 rs10854484 chr21:47926702 T/C cg12379764 chr21:47803548 PCNT 0.5 6.08 0.35 4.26e-9 Lymphocyte counts; CESC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs131777 0.575 rs963980 chr22:51022117 C/A cg25309564 chr22:51001381 C22orf41 0.62 7.96 0.44 5.08e-14 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg05457628 chr5:178986728 RUFY1 0.45 6.11 0.35 3.46e-9 Lung cancer; CESC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg05564831 chr3:52568323 NT5DC2 0.47 7.24 0.41 4.73e-12 Electroencephalogram traits; CESC cis rs894344 0.584 rs11985416 chr8:135634005 A/G cg27224718 chr8:135614730 ZFAT 0.38 5.07 0.3 7.37e-7 Systolic blood pressure; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg27139841 chr20:44718745 NCOA5 -0.44 -6.37 -0.36 8.47e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs12155623 0.803 rs7011862 chr8:49817333 C/G cg22283653 chr8:49824208 NA 0.37 5.36 0.31 1.83e-7 Sudden cardiac arrest; CESC cis rs7202877 0.656 rs977986 chr16:75506696 T/G cg03315344 chr16:75512273 CHST6 0.53 5.08 0.3 7.03e-7 Type 2 diabetes;Type 1 diabetes; CESC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs611744 0.647 rs631775 chr8:109252746 T/C cg21045802 chr8:109455806 TTC35 0.46 5.66 0.33 3.95e-8 Dupuytren's disease; CESC cis rs11190604 1.000 rs4919464 chr10:102221195 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs116095464 0.558 rs10080225 chr5:232175 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.87 0.39 4.6e-11 Breast cancer; CESC cis rs2243480 1.000 rs73150014 chr7:65450919 A/C cg12463550 chr7:65579703 CRCP 0.68 5.46 0.32 1.09e-7 Diabetic kidney disease; CESC cis rs4253772 0.938 rs41355347 chr22:46637511 G/A cg00784671 chr22:46762841 CELSR1 -0.57 -5.63 -0.33 4.54e-8 LDL cholesterol;Cholesterol, total; CESC cis rs367615 0.680 rs1103198 chr5:108973583 G/T cg17395555 chr5:108820864 NA 0.4 5.46 0.32 1.09e-7 Colorectal cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04567173 chr4:25379221 ANAPC4 0.66 7.18 0.4 6.82e-12 Gut microbiome composition (summer); CESC cis rs9715521 1.000 rs9715521 chr4:59824487 G/A cg11281224 chr4:60001000 NA -0.51 -6.67 -0.38 1.45e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg18252515 chr7:66147081 NA 0.48 6.43 0.37 5.77e-10 Aortic root size; CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg23131131 chr22:24373011 LOC391322 -0.73 -10.2 -0.53 7.73e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6580649 0.769 rs60629297 chr12:48438290 T/A cg24011408 chr12:48396354 COL2A1 -0.43 -5.37 -0.31 1.71e-7 Lung cancer; CESC cis rs9303401 0.703 rs9910629 chr17:57210301 C/G cg12560992 chr17:57184187 TRIM37 0.48 5.74 0.33 2.52e-8 Cognitive test performance; CESC cis rs28647808 0.881 rs7029256 chr9:136263655 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.73 0.33 2.7e-8 Blood protein levels; CESC cis rs897984 0.770 rs12930657 chr16:30931968 C/T cg00531865 chr16:30841666 NA 0.51 7.12 0.4 1.01e-11 Dementia with Lewy bodies; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27367093 chr11:72145746 CLPB 0.64 8.05 0.44 2.73e-14 Gut microbiome composition (summer); CESC cis rs637571 0.557 rs1204649 chr11:65702776 A/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.46 6.05 0.35 4.92e-9 Eosinophil percentage of white cells; CESC cis rs12701220 0.857 rs1057558 chr7:1062366 A/G cg26769984 chr7:1090371 C7orf50 0.61 6.92 0.39 3.3e-11 Bronchopulmonary dysplasia; CESC cis rs34779708 0.966 rs113170867 chr10:35450147 C/T cg04310649 chr10:35416472 CREM -0.51 -6.25 -0.36 1.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg01579765 chr21:45077557 HSF2BP -0.56 -9.21 -0.49 1.04e-17 Mean corpuscular volume; CESC cis rs1355223 0.902 rs11605785 chr11:34751387 G/A cg11058730 chr11:34937778 PDHX;APIP -0.46 -5.94 -0.34 8.84e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg24562669 chr7:97807699 LMTK2 0.51 7.53 0.42 7.86e-13 Prostate cancer (SNP x SNP interaction); CESC trans rs801193 0.839 rs6968619 chr7:66068867 T/C cg26939375 chr7:64535504 NA -0.54 -7.43 -0.42 1.53e-12 Aortic root size; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg25433490 chr11:72504708 STARD10 -0.45 -6.16 -0.35 2.62e-9 Asthma; CESC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg20151795 chr6:28129481 ZNF389 0.41 5.28 0.31 2.69e-7 Depression; CESC cis rs9902453 0.967 rs4533341 chr17:28495672 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.9 0.44 7.44e-14 Coffee consumption (cups per day); CESC cis rs9287719 0.967 rs2010080 chr2:10736552 A/T cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs6502050 0.605 rs35158616 chr17:80094480 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.04 -0.3 8.69e-7 Life satisfaction; CESC cis rs6714710 0.603 rs11678591 chr2:98541001 T/C cg26665480 chr2:98280029 ACTR1B 0.56 7.85 0.43 1.04e-13 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs6032067 0.704 rs2223901 chr20:43789924 C/G cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC cis rs9325144 0.752 rs12300353 chr12:39154492 G/C cg26384229 chr12:38710491 ALG10B -0.52 -6.97 -0.39 2.47e-11 Morning vs. evening chronotype; CESC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg05332525 chr7:65337924 VKORC1L1 0.51 6.21 0.36 1.99e-9 Calcium levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18528640 chr1:155579964 MSTO1 -0.48 -6.45 -0.37 5.32e-10 Gut microbiota (bacterial taxa); CESC cis rs713587 0.520 rs483428 chr2:25305136 A/G cg01884057 chr2:25150051 NA 0.31 5.34 0.31 2.04e-7 Body mass index in non-asthmatics; CESC trans rs7615952 0.641 rs12495947 chr3:125771698 C/T cg07211511 chr3:129823064 LOC729375 -0.59 -6.53 -0.37 3.37e-10 Blood pressure (smoking interaction); CESC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs9329221 0.512 rs7843924 chr8:9976540 C/T cg06636001 chr8:8085503 FLJ10661 0.49 6.46 0.37 4.99e-10 Neuroticism; CESC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 5.02e-9 Prudent dietary pattern; CESC cis rs7542091 0.635 rs7550733 chr1:210044968 G/A cg23283495 chr1:209979779 IRF6 0.35 5.8 0.34 1.84e-8 Monobrow; CESC cis rs897080 0.515 rs1067325 chr2:44628997 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs7927771 1.000 rs12418852 chr11:47868853 C/G cg05585544 chr11:47624801 NA -0.49 -7.61 -0.42 4.89e-13 Subjective well-being; CESC cis rs262150 0.579 rs73167299 chr7:158784367 C/T cg23096020 chr7:158799433 NA 0.46 5.1 0.3 6.48e-7 Facial morphology (factor 20); CESC cis rs7481584 0.962 rs2071110 chr11:2991219 C/G cg25174290 chr11:3078921 CARS -0.46 -5.55 -0.32 7.03e-8 Calcium levels; CESC cis rs4523957 0.928 rs216206 chr17:2196088 C/T cg16513277 chr17:2031491 SMG6 0.59 8.08 0.44 2.29e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9300255 0.620 rs7313483 chr12:123726834 C/T cg19016782 chr12:123741754 C12orf65 -0.48 -6.72 -0.38 1.09e-10 Neutrophil percentage of white cells; CESC cis rs10256972 0.528 rs7784607 chr7:1178694 A/G cg23978390 chr7:1156363 C7orf50 0.64 9.16 0.49 1.49e-17 Longevity;Endometriosis; CESC cis rs503341 0.756 rs10897450 chr11:63593219 G/C cg04362095 chr11:63592001 C11orf84 -0.58 -8.17 -0.45 1.26e-14 Pulse pressure; CESC cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg12386194 chr3:101231763 SENP7 0.44 5.38 0.31 1.64e-7 Colorectal cancer; CESC cis rs9309473 0.950 rs6546849 chr2:73831037 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.03 -0.35 5.44e-9 Metabolite levels; CESC cis rs1577917 1.000 rs12201741 chr6:86602619 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -5.41 -0.32 1.39e-7 Response to antipsychotic treatment; CESC cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.78 7.01 0.4 1.93e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07573057 chr8:82754234 SNX16 -0.47 -6.7 -0.38 1.25e-10 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27106230 chr13:99229068 STK24 0.57 6.33 0.36 1.04e-9 Gut microbiome composition (summer); CESC cis rs6502050 0.799 rs4789667 chr17:80162143 C/T cg23985595 chr17:80112537 CCDC57 -0.39 -6.29 -0.36 1.34e-9 Life satisfaction; CESC cis rs7264396 0.836 rs6058275 chr20:34186331 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -7.89 -0.44 7.84e-14 Total cholesterol levels; CESC cis rs7429990 0.932 rs7630685 chr3:48131170 G/C cg11946769 chr3:48343235 NME6 -0.51 -6.32 -0.36 1.11e-9 Educational attainment (years of education); CESC cis rs3741151 0.773 rs73544767 chr11:73204619 C/T cg17517138 chr11:73019481 ARHGEF17 0.98 7.17 0.4 7.42e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg25072359 chr17:41440525 NA 0.49 7.34 0.41 2.66e-12 Menopause (age at onset); CESC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg12516959 chr21:47718080 NA 0.41 5.97 0.34 7.7e-9 Testicular germ cell tumor; CESC cis rs3820068 0.581 rs72645877 chr1:15928106 G/T cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs2274273 0.905 rs8007944 chr14:55576816 A/C cg04306507 chr14:55594613 LGALS3 0.3 5.93 0.34 9.34e-9 Protein biomarker; CESC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg07395648 chr5:131743802 NA -0.41 -5.28 -0.31 2.65e-7 Breast cancer; CESC cis rs9300255 0.722 rs10773008 chr12:123800820 A/G cg00376283 chr12:123451042 ABCB9 0.59 6.86 0.39 4.85e-11 Neutrophil percentage of white cells; CESC cis rs2235642 0.750 rs2859310 chr16:1656765 C/T cg03715980 chr16:1756201 MAPK8IP3 -0.4 -5.27 -0.31 2.87e-7 Coronary artery disease; CESC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg07507251 chr3:52567010 NT5DC2 0.41 7.21 0.4 5.94e-12 Bipolar disorder; CESC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.26 0.79 3.33e-59 Prudent dietary pattern; CESC cis rs847577 0.715 rs4729402 chr7:97707731 A/G cg24562669 chr7:97807699 LMTK2 0.46 6.9 0.39 3.9e-11 Breast cancer; CESC trans rs801193 1.000 rs7782320 chr7:66177098 C/T cg26939375 chr7:64535504 NA 0.63 8.66 0.47 4.62e-16 Aortic root size; CESC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg17724175 chr1:150552817 MCL1 0.34 5.2 0.3 3.95e-7 Melanoma; CESC cis rs8077889 0.719 rs4793033 chr17:41879627 C/T cg26893861 chr17:41843967 DUSP3 0.94 14.98 0.68 3.69e-37 Triglycerides; CESC cis rs7044106 0.762 rs10984974 chr9:123421556 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.03 0.52 2.79e-20 Hip circumference adjusted for BMI; CESC cis rs3091242 0.933 rs3093584 chr1:25668714 T/C cg03538708 chr1:25844672 NA 0.37 5.45 0.32 1.17e-7 Erythrocyte sedimentation rate; CESC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg08859206 chr1:53392774 SCP2 -0.66 -8.92 -0.48 7.96e-17 Monocyte count; CESC cis rs11969893 0.737 rs9498439 chr6:101404768 A/T cg12253828 chr6:101329408 ASCC3 0.86 7.03 0.4 1.79e-11 Economic and political preferences (immigration/crime); CESC cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 10.11 0.53 1.55e-20 Platelet count; CESC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg07157834 chr1:205819609 PM20D1 0.68 10.03 0.52 2.87e-20 Menarche (age at onset); CESC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg04369109 chr6:150039330 LATS1 -0.42 -5.62 -0.33 4.88e-8 Lung cancer; CESC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg26516362 chr5:178986906 RUFY1 -0.48 -7.63 -0.42 4.15e-13 Lung cancer; CESC cis rs10129255 0.500 rs2027902 chr14:107215393 T/C cg07958169 chr14:107095056 NA -0.51 -7.65 -0.43 3.66e-13 Kawasaki disease; CESC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg08888203 chr3:10149979 C3orf24 0.46 6.01 0.35 6.24e-9 Alzheimer's disease; CESC cis rs7666738 0.830 rs62318472 chr4:98926030 G/A cg05340658 chr4:99064831 C4orf37 0.78 11.47 0.58 5.56e-25 Colonoscopy-negative controls vs population controls; CESC cis rs4144743 1.000 rs61312893 chr17:45325023 C/G cg18085866 chr17:45331354 ITGB3 -0.64 -6.99 -0.39 2.25e-11 Body mass index; CESC cis rs67257959 0.708 rs1979260 chr19:17193551 C/T cg16202187 chr19:17186497 HAUS8;MYO9B -0.42 -5.15 -0.3 5.06e-7 Selective IgA deficiency; CESC cis rs3857536 0.813 rs7757647 chr6:66947207 A/G cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs12142240 0.698 rs1053627 chr1:46827728 A/C cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs17401966 1.000 rs2229687 chr1:10473196 C/T cg15208524 chr1:10270712 KIF1B 0.4 5.11 0.3 6.19e-7 Hepatocellular carcinoma; CESC cis rs6982240 0.514 rs10481414 chr8:142275326 T/C cg27411547 chr8:142287226 NA -0.53 -7.4 -0.41 1.76e-12 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17941572 chr1:63784454 NA -0.37 -6.37 -0.36 8.45e-10 Gut microbiome composition (summer); CESC cis rs3796352 1.000 rs11714876 chr3:53101640 C/G cg07884673 chr3:53033167 SFMBT1 -0.62 -5.58 -0.32 5.96e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs8014204 1.000 rs8014374 chr14:75322914 G/A cg08847533 chr14:75593920 NEK9 -0.48 -6.07 -0.35 4.35e-9 Caffeine consumption; CESC cis rs17039065 0.920 rs56988845 chr4:109458114 T/C cg16022748 chr4:109541635 LOC285456;RPL34 0.64 6.02 0.35 5.84e-9 Gut microbiome composition (summer); CESC cis rs6120849 0.754 rs6087667 chr20:33651887 A/G cg24642439 chr20:33292090 TP53INP2 0.67 6.62 0.38 1.94e-10 Protein C levels; CESC trans rs17039065 0.920 rs73838435 chr4:109445261 A/G cg27151770 chr16:49620536 ZNF423 -0.51 -6.14 -0.35 3.03e-9 Gut microbiome composition (summer); CESC trans rs561341 0.700 rs79272796 chr17:30226974 T/C cg20587970 chr11:113659929 NA -0.61 -8.09 -0.45 2.19e-14 Hip circumference adjusted for BMI; CESC cis rs11583043 0.918 rs3850453 chr1:101408933 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.55 6.32 0.36 1.08e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg04025307 chr7:1156635 C7orf50 0.42 6.89 0.39 4.16e-11 Longevity;Endometriosis; CESC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg20243544 chr17:37824526 PNMT -0.47 -5.96 -0.34 7.99e-9 Glomerular filtration rate (creatinine); CESC cis rs654950 0.775 rs28972757 chr1:41993013 T/C cg06885757 chr1:42089581 HIVEP3 -0.44 -6.88 -0.39 4.38e-11 Airway imaging phenotypes; CESC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.64 0.47 5.42e-16 Electroencephalogram traits; CESC cis rs17125944 0.572 rs79312783 chr14:53250296 A/T cg00686598 chr14:53173677 PSMC6 1.37 11.76 0.59 5.78e-26 Alzheimer's disease (late onset); CESC cis rs11098499 0.955 rs1511019 chr4:120166007 T/G cg09307838 chr4:120376055 NA 0.87 11.42 0.57 7.94e-25 Corneal astigmatism; CESC trans rs1945213 0.694 rs7129022 chr11:55876132 A/G cg15704280 chr7:45808275 SEPT13 0.75 7.28 0.41 3.87e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.7 -7.85 -0.43 1.06e-13 Gut microbiome composition (summer); CESC cis rs7618501 0.521 rs6774354 chr3:49961780 G/A cg24308560 chr3:49941425 MST1R -0.6 -8.77 -0.47 2.17e-16 Intelligence (multi-trait analysis); CESC cis rs61935443 0.832 rs10859778 chr12:95268010 C/G cg21533806 chr12:95267307 NA 0.56 6.87 0.39 4.56e-11 Schizophrenia; CESC cis rs8078723 1.000 rs1042658 chr17:38173902 C/T cg17467752 chr17:38218738 THRA 0.66 9.91 0.52 6.68e-20 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs9309473 1.000 rs7584575 chr2:73666402 C/T cg20560298 chr2:73613845 ALMS1 -0.51 -6.76 -0.38 8.64e-11 Metabolite levels; CESC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.59 -0.38 2.36e-10 Depression; CESC cis rs796364 0.951 rs12613687 chr2:200999256 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.78 -0.38 7.71e-11 Schizophrenia; CESC cis rs67311347 1.000 rs2168111 chr3:40395325 T/G cg01475735 chr3:40494733 NA -0.42 -5.39 -0.31 1.55e-7 Renal cell carcinoma; CESC cis rs193541 0.632 rs246279 chr5:122241263 C/G cg19412675 chr5:122181750 SNX24 -0.6 -5.35 -0.31 1.95e-7 Glucose homeostasis traits; CESC cis rs6570726 1.000 rs951143 chr6:145932576 C/T cg05347473 chr6:146136440 FBXO30 0.45 6.26 0.36 1.56e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs763121 0.962 rs6001193 chr22:39074737 A/G cg06544989 chr22:39130855 UNC84B 0.47 8.98 0.48 5.09e-17 Menopause (age at onset); CESC cis rs2197308 0.606 rs12314897 chr12:38392293 C/T cg26384229 chr12:38710491 ALG10B -0.46 -6.11 -0.35 3.48e-9 Morning vs. evening chronotype; CESC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg13628971 chr7:2884303 GNA12 0.6 8.09 0.44 2.17e-14 Height; CESC cis rs6542838 0.641 rs10192266 chr2:99521837 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -5.98 -0.34 7.17e-9 Fear of minor pain; CESC cis rs9916302 0.653 rs4239223 chr17:37717004 T/C cg07936489 chr17:37558343 FBXL20 -0.98 -11.47 -0.58 5.54e-25 Glomerular filtration rate (creatinine); CESC cis rs473651 0.935 rs35080527 chr2:239351387 T/C cg18131467 chr2:239335373 ASB1 1.01 20.6 0.78 6.03e-57 Multiple system atrophy; CESC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.59 0.38 2.33e-10 Bipolar disorder; CESC cis rs3540 0.512 rs8033818 chr15:91075535 C/T cg22089800 chr15:90895588 ZNF774 -0.63 -8.16 -0.45 1.34e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs73058052 0.935 rs3745474 chr19:50086806 C/T cg09250473 chr19:50168907 IRF3;BCL2L12 0.56 5.26 0.31 2.94e-7 Fibrinogen levels; CESC cis rs12586317 0.534 rs28384418 chr14:35452126 C/A cg16230307 chr14:35515116 FAM177A1 0.84 10.26 0.53 5.07e-21 Psoriasis; CESC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg18016565 chr1:150552671 MCL1 0.34 5.16 0.3 4.95e-7 Tonsillectomy; CESC cis rs453301 0.631 rs7843369 chr8:8797786 T/G cg15556689 chr8:8085844 FLJ10661 -0.46 -5.09 -0.3 6.94e-7 Joint mobility (Beighton score); CESC cis rs1008375 0.863 rs7680984 chr4:17600884 A/G cg27347728 chr4:17578864 LAP3 0.45 5.44 0.32 1.21e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7208859 0.524 rs11653605 chr17:29088385 T/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8020095 0.571 rs9323484 chr14:67239632 C/T cg19548862 chr14:67692701 FAM71D -0.5 -6.25 -0.36 1.67e-9 Depression (quantitative trait); CESC cis rs4474465 0.920 rs10751291 chr11:78217687 T/C cg27205649 chr11:78285834 NARS2 0.43 5.47 0.32 1.05e-7 Alzheimer's disease (survival time); CESC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg18350739 chr11:68623251 NA -0.47 -6.92 -0.39 3.32e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs708547 0.697 rs67479587 chr4:57878884 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.47 6.61 0.38 2.11e-10 Response to bleomycin (chromatid breaks); CESC cis rs4953076 0.573 rs7593987 chr2:44393532 C/T cg04920474 chr2:44395004 PPM1B -0.57 -7.31 -0.41 3.1e-12 Height; CESC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg05234568 chr11:5960015 NA -0.64 -8.75 -0.47 2.46e-16 DNA methylation (variation); CESC cis rs977987 0.806 rs11862582 chr16:75431295 T/C cg03315344 chr16:75512273 CHST6 0.4 5.72 0.33 2.85e-8 Dupuytren's disease; CESC cis rs2976388 0.578 rs34956412 chr8:143822028 C/T cg24634471 chr8:143751801 JRK -0.46 -5.06 -0.3 7.87e-7 Urinary tract infection frequency; CESC cis rs3793683 0.965 rs3829131 chr10:134564627 A/G cg27286337 chr10:134555280 INPP5A -0.91 -14.24 -0.66 1.5e-34 Migraine; CESC cis rs881375 0.900 rs1008383 chr9:123683579 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 5.24 0.31 3.22e-7 Rheumatoid arthritis; CESC cis rs524281 0.861 rs12226649 chr11:65842047 T/C cg14036092 chr11:66035641 RAB1B -0.59 -6.01 -0.35 6.21e-9 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00695560 chr13:100153670 TM9SF2 0.57 6.61 0.38 2.09e-10 Gut microbiome composition (summer); CESC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg26314531 chr2:26401878 FAM59B -0.78 -8.62 -0.47 6.3e-16 Gut microbiome composition (summer); CESC cis rs2760061 0.626 rs672977 chr1:228120288 A/C cg02753203 chr1:228287806 NA -0.51 -7.43 -0.42 1.5e-12 Diastolic blood pressure; CESC cis rs1003719 0.751 rs56268364 chr21:38542765 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.57 -7.66 -0.43 3.53e-13 Eye color traits; CESC cis rs11711311 0.955 rs9851812 chr3:113412362 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.59 7.8 0.43 1.41e-13 IgG glycosylation; CESC cis rs2617583 0.967 rs2652510 chr5:1447860 C/T cg07151155 chr5:1473589 LPCAT1 -0.36 -5.53 -0.32 7.81e-8 Breast cancer; CESC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg12463550 chr7:65579703 CRCP -0.5 -6.32 -0.36 1.08e-9 Aortic root size; CESC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg12463550 chr7:65579703 CRCP -0.48 -6.0 -0.35 6.63e-9 Aortic root size; CESC cis rs35146811 0.883 rs4134903 chr7:99711040 G/A cg22906224 chr7:99728672 NA 0.44 5.18 0.3 4.45e-7 Coronary artery disease; CESC cis rs524281 0.731 rs476551 chr11:66006323 G/C cg14036092 chr11:66035641 RAB1B -0.51 -5.31 -0.31 2.35e-7 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05428912 chr6:42989345 C6orf153 0.61 7.08 0.4 1.26e-11 Gut microbiome composition (summer); CESC cis rs10754283 0.967 rs2002883 chr1:90105838 A/G cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC trans rs9975691 1 rs9975691 chr21:14928355 G/T cg08835464 chr7:142569053 TRPV6 -0.38 -6.08 -0.35 4.2e-9 Neurofibrillary tangles; CESC cis rs919433 0.750 rs788012 chr2:198229856 A/T cg10820045 chr2:198174542 NA 0.4 5.83 0.34 1.57e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg02187348 chr16:89574699 SPG7 0.6 8.22 0.45 9.44e-15 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26291698 chr6:43445274 TJAP1 0.57 6.23 0.36 1.85e-9 Gut microbiome composition (summer); CESC cis rs7762018 1.000 rs6904601 chr6:170131905 T/G cg05834625 chr6:170176447 C6orf70 0.66 7.82 0.43 1.29e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg21724239 chr8:58056113 NA 0.55 6.39 0.37 7.47e-10 Developmental language disorder (linguistic errors); CESC cis rs2637266 0.678 rs1660918 chr10:78511674 T/A cg18941641 chr10:78392320 NA 0.39 7.43 0.42 1.46e-12 Pulmonary function; CESC trans rs7618501 0.633 rs7621026 chr3:49975334 A/G cg21659725 chr3:3221576 CRBN 0.49 6.81 0.39 6.69e-11 Intelligence (multi-trait analysis); CESC cis rs6942756 1.000 rs67520056 chr7:128982075 A/G cg02491457 chr7:128862824 NA -0.67 -9.08 -0.49 2.54e-17 White matter hyperintensity burden; CESC cis rs2439831 1.000 rs2467740 chr15:43746792 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.68 0.55 2.22e-22 Lung cancer in ever smokers; CESC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.66 0.33 3.97e-8 Bipolar disorder; CESC cis rs7772486 0.875 rs10872582 chr6:146373061 G/A cg23711669 chr6:146136114 FBXO30 0.76 11.07 0.56 1.13e-23 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08434152 chr2:74405770 MOBKL1B -0.6 -6.38 -0.36 7.83e-10 Gut microbiome composition (summer); CESC cis rs709400 0.628 rs1951392 chr14:103853367 T/G cg12935359 chr14:103987150 CKB -0.52 -7.36 -0.41 2.34e-12 Body mass index; CESC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg22029157 chr1:209979665 IRF6 0.69 8.04 0.44 3.04e-14 Cleft lip with or without cleft palate; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10432265 chr11:94800316 SFRS2B -0.37 -6.16 -0.35 2.67e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18064852 chr5:36690457 NA 0.61 7.15 0.4 8.37e-12 Gut microbiome composition (summer); CESC cis rs2455799 0.552 rs2470516 chr3:15759050 T/G cg09340198 chr3:15902540 ANKRD28 -0.33 -5.1 -0.3 6.39e-7 Mean platelet volume; CESC cis rs2933343 0.951 rs789251 chr3:128576770 G/A cg25356066 chr3:128598488 ACAD9 0.59 7.53 0.42 8.02e-13 IgG glycosylation; CESC cis rs921968 0.541 rs4674314 chr2:219423520 A/G cg02176678 chr2:219576539 TTLL4 -0.48 -8.44 -0.46 2.08e-15 Mean corpuscular hemoglobin concentration; CESC cis rs9549367 0.789 rs2302757 chr13:113909339 A/G cg18105134 chr13:113819100 PROZ -0.72 -8.87 -0.48 1.09e-16 Platelet distribution width; CESC cis rs9815354 1.000 rs7622259 chr3:41881351 A/T cg03022575 chr3:42003672 ULK4 0.45 5.29 0.31 2.59e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs9640161 0.830 rs7800196 chr7:150061534 C/G cg13722127 chr7:150037890 RARRES2 0.33 5.12 0.3 5.77e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs877282 0.755 rs2486578 chr10:785227 C/T cg22713356 chr15:30763199 NA -1.0 -11.0 -0.56 2.04e-23 Uric acid levels; CESC cis rs634534 0.562 rs642293 chr11:65730217 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.65 0.38 1.68e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs8002861 0.626 rs9533634 chr13:44397815 T/C cg19180546 chr13:44453867 C13orf31;CCDC122 -0.41 -5.26 -0.31 3e-7 Leprosy; CESC cis rs10870270 0.956 rs10430618 chr10:133748996 C/T cg17892150 chr10:133769511 PPP2R2D -0.87 -12.74 -0.62 2.55e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg11301795 chr4:187892539 NA 0.76 12.39 0.61 4.09e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs4243830 0.737 rs4908926 chr1:6617041 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.84 -8.41 -0.46 2.58e-15 Body mass index; CESC cis rs11123406 0.651 rs11123407 chr2:111950594 A/C cg04202892 chr2:111875749 ACOXL 0.36 5.09 0.3 6.79e-7 Type 2 diabetes; CESC cis rs523522 0.962 rs4767914 chr12:120993817 C/T cg27279351 chr12:120934652 DYNLL1 0.68 8.7 0.47 3.47e-16 High light scatter reticulocyte count; CESC trans rs61931739 0.500 rs7306053 chr12:34510848 T/G cg26384229 chr12:38710491 ALG10B 0.54 7.55 0.42 7.05e-13 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02767759 chr16:30366751 CD2BP2 -0.45 -6.6 -0.38 2.28e-10 Gambling; CESC cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg02487422 chr3:49467188 NICN1 0.39 5.1 0.3 6.42e-7 Parkinson's disease; CESC cis rs17376456 0.569 rs6879620 chr5:93119893 G/A cg21475434 chr5:93447410 FAM172A -0.51 -5.16 -0.3 4.88e-7 Diabetic retinopathy; CESC cis rs524281 0.861 rs535395 chr11:65906534 A/G cg14036092 chr11:66035641 RAB1B 0.54 5.91 0.34 1.06e-8 Electroencephalogram traits; CESC trans rs561341 1.000 rs7216102 chr17:30259450 A/G cg20587970 chr11:113659929 NA -0.79 -10.26 -0.53 5.01e-21 Hip circumference adjusted for BMI; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg15708219 chr10:22621481 NA 0.44 6.03 0.35 5.52e-9 Thyroid stimulating hormone; CESC cis rs2635047 0.542 rs11082567 chr18:44769820 C/T cg24371990 chr18:44770781 NA 0.36 5.95 0.34 8.29e-9 Educational attainment; CESC cis rs9644630 0.930 rs6586839 chr8:19365543 A/T cg01280390 chr8:19363452 CSGALNACT1 -0.33 -5.1 -0.3 6.54e-7 Oropharynx cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13149330 chr1:174968980 CACYBP 0.58 6.02 0.35 5.82e-9 Gut microbiome composition (summer); CESC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg13393036 chr8:95962371 TP53INP1 -0.49 -10.7 -0.55 1.94e-22 Type 2 diabetes; CESC cis rs4664308 1.000 rs17831161 chr2:160909360 A/G cg03641300 chr2:160917029 PLA2R1 -0.68 -10.17 -0.53 9.82e-21 Idiopathic membranous nephropathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22162225 chr2:62932835 EHBP1 0.63 8.02 0.44 3.49e-14 Gut microbiome composition (summer); CESC cis rs3806843 0.735 rs801189 chr5:140063091 A/G cg26395211 chr5:140044315 WDR55 0.47 6.03 0.35 5.51e-9 Depressive symptoms (multi-trait analysis); CESC cis rs12586317 0.547 rs45531432 chr14:35484423 C/T cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.22e-22 Psoriasis; CESC cis rs2070488 0.775 rs961179 chr3:38509618 G/A cg24069376 chr3:38537580 EXOG 0.35 6.0 0.35 6.43e-9 Electrocardiographic conduction measures; CESC cis rs9640161 0.789 rs66688634 chr7:150053806 G/A cg21361702 chr7:150065534 REPIN1 0.61 6.61 0.38 2.09e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg04756594 chr16:24857601 SLC5A11 0.45 5.35 0.31 1.91e-7 Intelligence (multi-trait analysis); CESC cis rs9486715 0.838 rs9386473 chr6:96873341 C/A cg18709589 chr6:96969512 KIAA0776 0.45 6.51 0.37 3.65e-10 Headache; CESC cis rs155076 0.666 rs4638420 chr13:21872348 A/G cg11317459 chr13:21872234 NA 1.21 14.76 0.67 2.21e-36 White matter hyperintensity burden; CESC trans rs2207136 0.868 rs3843525 chr6:50837217 C/G cg06522515 chr3:184090630 THPO 0.39 6.78 0.38 7.81e-11 Myopia; CESC cis rs9300255 0.602 rs2682431 chr12:123703226 T/A cg00376283 chr12:123451042 ABCB9 0.7 8.89 0.48 9.66e-17 Neutrophil percentage of white cells; CESC trans rs3942852 0.774 rs924715 chr11:48181060 G/A cg03929089 chr4:120376271 NA -0.65 -7.08 -0.4 1.3e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg05754148 chr16:3507555 NAT15 -0.58 -5.62 -0.33 4.77e-8 Tuberculosis; CESC cis rs4692589 1.000 rs1871683 chr4:170937348 T/C cg19918862 chr4:170955249 NA 0.36 5.65 0.33 4.07e-8 Anxiety disorder; CESC cis rs763121 0.853 rs138712 chr22:39141600 C/T cg06544989 chr22:39130855 UNC84B 0.5 9.06 0.49 2.94e-17 Menopause (age at onset); CESC cis rs8114671 0.562 rs2424999 chr20:33386430 G/A cg08999081 chr20:33150536 PIGU 0.37 5.08 0.3 7.17e-7 Height; CESC cis rs79349575 0.783 rs903567 chr17:46980318 C/T cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs9303280 0.901 rs1008723 chr17:38066267 G/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.47 -0.32 1.06e-7 Self-reported allergy; CESC cis rs1707322 0.928 rs7527244 chr1:46368772 A/G cg03146154 chr1:46216737 IPP 0.74 10.16 0.53 1.08e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg24549020 chr5:56110836 MAP3K1 0.59 6.95 0.39 2.75e-11 Initial pursuit acceleration; CESC cis rs3126085 0.935 rs10888467 chr1:152171707 C/T cg03465714 chr1:152285911 FLG -0.42 -5.37 -0.31 1.73e-7 Atopic dermatitis; CESC cis rs137603 0.623 rs470075 chr22:39686806 G/A cg01093212 chr22:39715156 SNORD43;RPL3 -0.41 -5.04 -0.3 8.65e-7 Primary biliary cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18426487 chr10:35379348 CUL2 0.61 7.05 0.4 1.56e-11 Gut microbiome composition (summer); CESC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg17221315 chr6:27791827 HIST1H4J 0.42 5.34 0.31 1.98e-7 Parkinson's disease; CESC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.72 0.62 2.88e-29 Alzheimer's disease; CESC cis rs3812762 0.871 rs11042068 chr11:8815599 C/G cg03980550 chr11:8754370 ST5 -0.38 -5.12 -0.3 5.96e-7 Hypospadias; CESC cis rs818427 0.593 rs351768 chr5:112200028 T/A cg07820702 chr5:112228657 REEP5 0.39 5.27 0.31 2.82e-7 Total body bone mineral density; CESC cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -6.71 -0.38 1.14e-10 Personality dimensions; CESC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg00080972 chr5:178986291 RUFY1 -0.48 -7.8 -0.43 1.47e-13 Lung cancer; CESC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg04944784 chr2:26401820 FAM59B -0.63 -7.23 -0.41 5.29e-12 Gut microbiome composition (summer); CESC cis rs1371867 0.810 rs1618528 chr8:101259134 T/C cg11906718 chr8:101322791 RNF19A -0.48 -6.04 -0.35 5.21e-9 Atrioventricular conduction; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26399201 chr5:132149404 ANKRD43 0.49 6.09 0.35 3.99e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1153858 0.723 rs4580098 chr15:45596909 T/A cg14582100 chr15:45693742 SPATA5L1 0.38 5.28 0.31 2.76e-7 Homoarginine levels; CESC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg18252515 chr7:66147081 NA -0.43 -5.59 -0.32 5.73e-8 Aortic root size; CESC cis rs2070677 0.935 rs11101887 chr10:135418062 G/A cg20169779 chr10:135381914 SYCE1 -0.74 -9.71 -0.51 2.99e-19 Gout; CESC cis rs3008870 1.000 rs2065000 chr1:67468124 G/C cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -14.35 -0.66 6.26e-35 Lymphocyte percentage of white cells; CESC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.15 0.3 4.98e-7 Cognitive function; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg05360402 chr5:110848191 STARD4 0.48 6.48 0.37 4.45e-10 Systemic lupus erythematosus; CESC cis rs66573146 1.000 rs56074877 chr4:6990374 C/T cg00086871 chr4:6988644 TBC1D14 1.18 7.59 0.42 5.45e-13 Granulocyte percentage of myeloid white cells; CESC cis rs12930096 1.000 rs12921437 chr16:11680148 T/C cg07439791 chr16:11680400 LITAF 0.62 5.5 0.32 8.93e-8 QT interval; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05610740 chr12:96794311 CDK17 -0.49 -6.32 -0.36 1.11e-9 Fibrinogen levels; CESC cis rs921968 0.509 rs655441 chr2:219357545 C/T cg02176678 chr2:219576539 TTLL4 0.5 8.98 0.48 5.22e-17 Mean corpuscular hemoglobin concentration; CESC cis rs3733585 0.699 rs6449171 chr4:9965998 C/T cg00071950 chr4:10020882 SLC2A9 0.72 11.29 0.57 2.15e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs875971 1.000 rs1363055 chr7:65943275 A/G cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs9894429 0.671 rs6565616 chr17:79612161 C/T cg18240062 chr17:79603768 NPLOC4 0.53 7.0 0.4 2.07e-11 Eye color traits; CESC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg04414720 chr1:150670196 GOLPH3L -0.6 -8.42 -0.46 2.42e-15 Tonsillectomy; CESC cis rs67311347 0.956 rs7640228 chr3:40516190 G/A cg09455208 chr3:40491958 NA -0.5 -8.39 -0.46 3.02e-15 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15302530 chr7:108210038 THAP5;DNAJB9 0.53 6.38 0.36 7.68e-10 Gut microbiome composition (summer); CESC cis rs1865721 0.771 rs7228890 chr18:73137492 C/A cg26385618 chr18:73139727 C18orf62 -0.48 -7.92 -0.44 6.58e-14 Intelligence; CESC cis rs8114671 0.869 rs1544047 chr20:33670753 T/C cg24642439 chr20:33292090 TP53INP2 -0.47 -5.7 -0.33 3.19e-8 Height; CESC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg04025307 chr7:1156635 C7orf50 0.42 5.85 0.34 1.47e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg11494091 chr17:61959527 GH2 0.73 12.69 0.61 3.72e-29 Prudent dietary pattern; CESC cis rs506597 0.920 rs221800 chr7:100288552 T/C cg10426581 chr7:100472382 SRRT -0.69 -5.39 -0.31 1.57e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg18876405 chr7:65276391 NA -0.51 -7.0 -0.4 2.05e-11 Aortic root size; CESC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg24531977 chr5:56204891 C5orf35 -0.87 -10.95 -0.56 2.88e-23 Initial pursuit acceleration; CESC cis rs7131987 0.934 rs7316004 chr12:29411698 C/T cg09582351 chr12:29534625 ERGIC2 -0.35 -5.72 -0.33 2.9e-8 QT interval; CESC cis rs838147 0.563 rs281379 chr19:49214274 C/T cg21064579 chr19:49206444 FUT2 0.4 5.49 0.32 9.5e-8 Dietary macronutrient intake; CESC cis rs10832963 1.000 rs10128711 chr11:18632984 A/G cg20219074 chr11:18656078 SPTY2D1 0.79 11.73 0.58 7.39e-26 Breast cancer; CESC cis rs1059312 0.966 rs12370194 chr12:129277250 A/T cg09035930 chr12:129282057 SLC15A4 0.75 10.45 0.54 1.28e-21 Systemic lupus erythematosus; CESC trans rs7937682 0.921 rs688354 chr11:111438762 A/G cg18187862 chr3:45730750 SACM1L 0.49 6.04 0.35 5.29e-9 Primary sclerosing cholangitis; CESC cis rs7795096 0.743 rs9648729 chr7:151537759 G/C cg17008978 chr7:151542804 PRKAG2 0.4 7.39 0.41 1.97e-12 Bipolar disorder (age of onset and psychotic symptoms); CESC cis rs7618501 0.633 rs2008877 chr3:50162291 T/G cg24110177 chr3:50126178 RBM5 0.52 7.02 0.4 1.91e-11 Intelligence (multi-trait analysis); CESC cis rs8103278 0.507 rs10401971 chr19:46261982 C/T cg14061069 chr19:46274453 DMPK 0.52 8.23 0.45 8.37e-15 Coronary artery disease; CESC cis rs7605827 0.930 rs765432 chr2:15561440 C/T cg19274914 chr2:15703543 NA -0.32 -5.7 -0.33 3.16e-8 Educational attainment (years of education); CESC cis rs6723226 0.721 rs10172510 chr2:32620888 A/G cg02381751 chr2:32503542 YIPF4 0.54 6.89 0.39 4.14e-11 Intelligence (multi-trait analysis); CESC cis rs4819052 0.851 rs2838866 chr21:46713014 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 8.97 0.48 5.5e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10465746 0.935 rs6687372 chr1:84447634 C/T cg10977910 chr1:84465055 TTLL7 0.46 6.31 0.36 1.14e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06273413 chr7:92157551 PEX1;C7orf64 0.62 6.72 0.38 1.11e-10 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03112782 chr1:37979729 MEAF6 0.53 6.79 0.38 7.55e-11 Gut microbiota (bacterial taxa); CESC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg08470875 chr2:26401718 FAM59B -0.57 -6.09 -0.35 3.95e-9 Gut microbiome composition (summer); CESC cis rs4891159 0.790 rs35516239 chr18:74129942 C/T cg24786174 chr18:74118243 ZNF516 -0.73 -11.51 -0.58 3.96e-25 Longevity; CESC cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4919694 1.000 rs35159404 chr10:104805610 C/A cg04362960 chr10:104952993 NT5C2 0.8 6.89 0.39 4.13e-11 Arsenic metabolism; CESC cis rs9488822 0.676 rs1556857 chr6:116325559 T/C cg05304507 chr6:116381966 FRK 0.26 6.56 0.37 2.82e-10 Cholesterol, total;LDL cholesterol; CESC cis rs1707322 0.721 rs4431884 chr1:46101323 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.31 0.41 3.1e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9443645 0.901 rs9352666 chr6:79572184 C/G cg05283184 chr6:79620031 NA -0.44 -6.84 -0.39 5.6e-11 Intelligence (multi-trait analysis); CESC trans rs9850225 0.666 rs2372669 chr3:81029234 T/G cg27138204 chr12:54446100 HOXC4 -0.37 -6.06 -0.35 4.76e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs12142240 0.698 rs66847432 chr1:46832013 G/A cg00530320 chr1:46809349 NSUN4 0.6 8.08 0.44 2.37e-14 Menopause (age at onset); CESC cis rs6499255 0.951 rs8054096 chr16:69695886 G/A cg15192750 chr16:69999425 NA 0.46 5.34 0.31 2.04e-7 IgE levels; CESC cis rs459571 0.920 rs417142 chr9:136891370 G/T cg13789015 chr9:136890014 NCRNA00094 0.55 7.9 0.44 7.61e-14 Platelet distribution width; CESC cis rs6463523 0.864 rs73047957 chr7:759373 A/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.96 14.73 0.67 2.83e-36 Subjective well-being; CESC cis rs524281 1.000 rs547087 chr11:65846264 A/G cg14036092 chr11:66035641 RAB1B 0.53 5.88 0.34 1.21e-8 Electroencephalogram traits; CESC cis rs35146811 0.586 rs6946168 chr7:99598286 C/T cg22531904 chr7:99595276 NA -0.4 -5.21 -0.3 3.79e-7 Coronary artery disease; CESC cis rs7618915 0.501 rs55678971 chr3:52717229 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.59 8.06 0.44 2.58e-14 Bipolar disorder; CESC cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg18402987 chr7:1209562 NA 0.4 5.1 0.3 6.61e-7 Longevity;Endometriosis; CESC cis rs1707322 0.721 rs11211178 chr1:46227566 G/T cg03146154 chr1:46216737 IPP 0.81 11.44 0.58 6.59e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7264396 0.563 rs2425071 chr20:34292961 A/C cg04508476 chr20:34239394 CPNE1;RBM12 0.88 10.58 0.55 4.63e-22 Total cholesterol levels; CESC cis rs853679 0.607 rs13203816 chr6:28079598 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 5.58 0.32 6.04e-8 Depression; CESC cis rs748404 0.646 rs2253268 chr15:43800968 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.72 0.43 2.32e-13 Lung cancer; CESC cis rs9921222 0.585 rs7195617 chr16:376781 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 -0.44 -7.12 -0.4 9.88e-12 Bone mineral density (spine);Bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17173397 chr1:20539594 NA -0.48 -6.51 -0.37 3.68e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg20887711 chr4:1340912 KIAA1530 0.7 9.7 0.51 3.15e-19 Longevity; CESC cis rs858239 0.511 rs10256996 chr7:23145295 G/T cg23682824 chr7:23144976 KLHL7 -0.47 -6.33 -0.36 1.05e-9 Cerebrospinal fluid biomarker levels; CESC cis rs4523957 0.671 rs4790070 chr17:2158094 C/G cg16513277 chr17:2031491 SMG6 0.48 5.49 0.32 9.45e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.47 7.03 0.4 1.77e-11 Total body bone mineral density; CESC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg26516362 chr5:178986906 RUFY1 0.47 7.52 0.42 8.62e-13 Lung cancer; CESC cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg10523679 chr1:76189770 ACADM 0.71 6.85 0.39 5e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9341808 0.667 rs1408292 chr6:80883906 G/T cg08355045 chr6:80787529 NA 0.32 5.05 0.3 8.21e-7 Sitting height ratio; CESC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg13628971 chr7:2884303 GNA12 0.62 8.28 0.45 6.17e-15 Height; CESC cis rs79839061 0.636 rs76839318 chr4:837810 T/A cg07828340 chr4:882639 GAK 0.86 5.9 0.34 1.09e-8 Intelligence (multi-trait analysis); CESC trans rs9858542 0.953 rs9814873 chr3:49454112 A/G cg21659725 chr3:3221576 CRBN -0.5 -6.23 -0.36 1.82e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7584330 0.657 rs10190310 chr2:238352282 C/T cg14458575 chr2:238380390 NA 0.64 8.9 0.48 9.09e-17 Prostate cancer; CESC cis rs17001868 0.568 rs9611318 chr22:40739414 C/G cg07138101 chr22:40742427 ADSL 0.57 5.38 0.31 1.66e-7 Mammographic density (dense area); CESC cis rs644799 0.965 rs566877 chr11:95528045 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs12900413 0.687 rs13343254 chr15:90311283 G/A cg24249390 chr15:90295951 MESP1 -0.4 -5.5 -0.32 9.05e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs11676348 0.772 rs11687200 chr2:218944615 A/G cg00012203 chr2:219082015 ARPC2 -0.44 -5.54 -0.32 7.45e-8 Ulcerative colitis; CESC cis rs796364 0.806 rs112305133 chr2:201010380 A/G cg23649088 chr2:200775458 C2orf69 -0.58 -5.71 -0.33 3.07e-8 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12349571 chr15:70364359 TLE3 0.45 6.33 0.36 1.05e-9 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22182611 chr19:1503537 NA -0.45 -6.08 -0.35 4.23e-9 Fibrinogen levels; CESC cis rs12545109 0.765 rs2438063 chr8:57384360 A/G cg09654669 chr8:57350985 NA 0.59 6.93 0.39 3.19e-11 Obesity-related traits; CESC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.28 0.53 4.4e-21 Prudent dietary pattern; CESC cis rs9916302 0.784 rs4795361 chr17:37573446 G/A cg15445000 chr17:37608096 MED1 0.41 6.81 0.39 6.45e-11 Glomerular filtration rate (creatinine); CESC cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg21918786 chr6:109611834 NA -0.41 -6.13 -0.35 3.24e-9 Reticulocyte fraction of red cells; CESC trans rs61931739 0.500 rs11053249 chr12:34518834 A/T cg26384229 chr12:38710491 ALG10B 0.7 10.48 0.54 1e-21 Morning vs. evening chronotype; CESC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg03351412 chr1:154909251 PMVK -0.58 -7.41 -0.41 1.66e-12 Prostate cancer; CESC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Parkinson's disease; CESC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.44 6.52 0.37 3.58e-10 Total body bone mineral density; CESC cis rs425277 1.000 rs436045 chr1:2071556 A/G cg04315214 chr1:2043799 PRKCZ 0.4 5.65 0.33 4.14e-8 Height; CESC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg05564831 chr3:52568323 NT5DC2 0.44 6.38 0.36 7.86e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01728682 chr2:25057480 ADCY3 -0.58 -6.84 -0.39 5.42e-11 Gut microbiome composition (summer); CESC cis rs12200560 0.505 rs211167 chr6:97069087 T/A cg06623918 chr6:96969491 KIAA0776 0.46 5.81 0.34 1.82e-8 Coronary heart disease; CESC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg02071572 chr4:1403502 NA 0.37 5.48 0.32 9.71e-8 Longevity; CESC trans rs208520 1.000 rs208529 chr6:66957549 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.78 -8.63 -0.47 5.64e-16 Exhaled nitric oxide output; CESC cis rs711830 1.000 rs1318778 chr2:177037831 C/G cg13092806 chr2:177043255 NA 0.88 12.03 0.59 6.83e-27 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CESC cis rs9814567 0.712 rs9838889 chr3:134332311 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.1 -0.3 6.38e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg17949981 chr6:28129498 ZNF389 0.45 5.49 0.32 9.35e-8 Depression; CESC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg02725872 chr8:58115012 NA -0.37 -5.94 -0.34 8.87e-9 Developmental language disorder (linguistic errors); CESC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg10691866 chr7:65817282 TPST1 0.33 5.55 0.32 6.96e-8 Aortic root size; CESC cis rs6430585 0.583 rs3769008 chr2:136586183 C/T cg07169764 chr2:136633963 MCM6 1.28 18.11 0.74 3.06e-48 Corneal structure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24568548 chr11:43544500 NA 0.46 6.55 0.37 2.97e-10 Fibrinogen levels; CESC cis rs1577917 1.000 rs34106666 chr6:86676258 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -5.67 -0.33 3.66e-8 Response to antipsychotic treatment; CESC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg17949981 chr6:28129498 ZNF389 0.45 5.71 0.33 3.07e-8 Depression; CESC cis rs6088590 1.000 rs10048849 chr20:33419680 C/T cg08999081 chr20:33150536 PIGU 0.59 8.93 0.48 7.21e-17 Coronary artery disease; CESC cis rs2721195 0.874 rs2721173 chr8:145744429 C/T cg22382021 chr8:145755756 MGC70857;KIAA1688 -0.31 -5.28 -0.31 2.75e-7 Age at first birth; CESC cis rs611744 0.647 rs1448151 chr8:109276283 C/A cg21045802 chr8:109455806 TTC35 0.49 6.08 0.35 4.24e-9 Dupuytren's disease; CESC cis rs10911232 0.507 rs4596846 chr1:182976034 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Hypertriglyceridemia; CESC cis rs1003719 0.788 rs2835595 chr21:38466203 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs116095464 1.000 rs28416084 chr5:217640 G/A cg16372103 chr5:203701 NA 0.49 5.29 0.31 2.58e-7 Breast cancer; CESC cis rs7584330 0.518 rs7561919 chr2:238435241 A/G cg14458575 chr2:238380390 NA 0.68 6.47 0.37 4.76e-10 Prostate cancer; CESC cis rs9790314 0.846 rs7636941 chr3:160993928 A/G cg03342759 chr3:160939853 NMD3 -0.51 -7.37 -0.41 2.23e-12 Morning vs. evening chronotype; CESC cis rs1461503 0.780 rs75981430 chr11:122842469 A/C cg27398637 chr11:122830231 C11orf63 -0.54 -8.02 -0.44 3.32e-14 Menarche (age at onset); CESC cis rs68170813 0.559 rs75932578 chr7:106844694 C/T cg02696742 chr7:106810147 HBP1 -0.53 -5.09 -0.3 6.93e-7 Coronary artery disease; CESC cis rs1003719 0.737 rs2835587 chr21:38461795 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.21e-16 Eye color traits; CESC cis rs2901656 0.677 rs2301455 chr1:172418268 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.52 7.91 0.44 7.02e-14 Red cell distribution width;Platelet distribution width; CESC cis rs832540 0.931 rs832535 chr5:56213334 C/T cg24531977 chr5:56204891 C5orf35 -0.44 -5.56 -0.32 6.56e-8 Coronary artery disease; CESC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg03806693 chr22:41940476 POLR3H -1.01 -12.06 -0.6 5.63e-27 Vitiligo; CESC cis rs4835473 0.897 rs12649594 chr4:144910460 T/C cg25736465 chr4:144833511 NA 0.42 6.43 0.37 6.02e-10 Immature fraction of reticulocytes; CESC cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.24e-9 Extrinsic epigenetic age acceleration; CESC cis rs2342371 0.816 rs11707744 chr3:196213855 C/G cg15048948 chr3:196158458 UBXN7 -0.4 -5.03 -0.3 9.04e-7 Fat distribution (HIV); CESC cis rs8067354 0.872 rs1295925 chr17:57910263 T/C cg13753209 chr17:57696993 CLTC -0.52 -7.03 -0.4 1.71e-11 Hemoglobin concentration; CESC cis rs3820068 0.581 rs6692489 chr1:15928517 A/G cg17385448 chr1:15911702 AGMAT 0.44 7.16 0.4 7.97e-12 Systolic blood pressure; CESC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.81 0.52 1.44e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 11.23 0.57 3.37e-24 Hip circumference adjusted for BMI; CESC trans rs61931739 0.534 rs11053016 chr12:34104372 C/T cg26384229 chr12:38710491 ALG10B 0.59 8.18 0.45 1.17e-14 Morning vs. evening chronotype; CESC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg11301795 chr4:187892539 NA -0.75 -12.39 -0.61 3.91e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs4243830 0.649 rs11579888 chr1:6609896 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -8.42 -0.46 2.37e-15 Body mass index; CESC cis rs4523957 0.928 rs12943566 chr17:2157774 A/G cg16513277 chr17:2031491 SMG6 0.59 7.92 0.44 6.65e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs35110281 0.782 rs4818856 chr21:45043495 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 6.9 0.39 3.75e-11 Mean corpuscular volume; CESC cis rs9486719 0.948 rs2472881 chr6:96862562 C/T cg06623918 chr6:96969491 KIAA0776 0.82 8.4 0.46 2.72e-15 Migraine;Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18842717 chr11:3400387 ZNF195 -0.46 -6.24 -0.36 1.73e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1801251 1.000 rs283480 chr2:233648742 G/A cg08000102 chr2:233561755 GIGYF2 0.67 9.28 0.5 6.17e-18 Coronary artery disease; CESC cis rs72781680 1.000 rs6731001 chr2:24192952 A/G cg08917208 chr2:24149416 ATAD2B 0.94 8.54 0.46 1.09e-15 Lymphocyte counts; CESC cis rs727505 1.000 rs55964341 chr7:124517280 A/G cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg10862848 chr6:42927986 GNMT -0.29 -7.24 -0.41 4.79e-12 Alzheimer's disease in APOE e4+ carriers; CESC cis rs12950390 0.776 rs4793646 chr17:45853966 A/C cg00777063 chr17:45855553 NA -0.39 -5.74 -0.33 2.62e-8 IgG glycosylation; CESC cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 11.29 0.57 2.2e-24 Hip circumference adjusted for BMI; CESC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg07701084 chr6:150067640 NUP43 0.43 5.85 0.34 1.45e-8 Lung cancer; CESC cis rs7520050 1.000 rs12410070 chr1:46358882 T/C cg24296786 chr1:45957014 TESK2 0.42 5.23 0.31 3.53e-7 Red blood cell count;Reticulocyte count; CESC cis rs9875589 0.509 rs1488379 chr3:14014719 A/G cg19554555 chr3:13937349 NA -0.44 -5.61 -0.33 5.2e-8 Ovarian reserve; CESC cis rs6032067 0.925 rs35751129 chr20:43847658 C/A cg11264863 chr20:43835661 SEMG1 0.48 5.13 0.3 5.65e-7 Blood protein levels; CESC cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.94 0.48 6.87e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11958404 0.929 rs60700182 chr5:157438376 A/G cg05962755 chr5:157440814 NA 0.59 6.52 0.37 3.45e-10 IgG glycosylation; CESC cis rs11920090 0.722 rs5404 chr3:170724955 A/G cg09710316 chr3:170744871 SLC2A2 -0.54 -6.2 -0.36 2.17e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg12463550 chr7:65579703 CRCP 0.49 6.11 0.35 3.61e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23610820 chr19:43774921 PSG9 -0.5 -6.24 -0.36 1.68e-9 Gut microbiome composition (summer); CESC cis rs614226 0.935 rs17431717 chr12:120912210 G/A cg01236616 chr12:121019343 POP5 -1.43 -15.07 -0.68 1.72e-37 Type 1 diabetes nephropathy; CESC cis rs9911578 1.000 rs11870671 chr17:56605360 A/G cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.5e-11 Intelligence (multi-trait analysis); CESC cis rs9640161 0.750 rs3735173 chr7:150020526 C/T cg21361702 chr7:150065534 REPIN1 0.52 6.08 0.35 4.06e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg18876405 chr7:65276391 NA -0.55 -7.48 -0.42 1.12e-12 Aortic root size; CESC cis rs2074585 0.647 rs2601188 chr15:90929563 A/G cg10434728 chr15:90938212 IQGAP1 -0.41 -7.48 -0.42 1.08e-12 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs3824867 0.920 rs4752836 chr11:47465095 T/C cg20307385 chr11:47447363 PSMC3 0.51 6.09 0.35 3.96e-9 Mean corpuscular hemoglobin; CESC cis rs2066819 1.000 rs79824801 chr12:56728137 T/C cg26734620 chr12:56694298 CS 0.98 5.95 0.34 8.45e-9 Psoriasis vulgaris; CESC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.79 13.27 0.63 3.82e-31 Personality dimensions; CESC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg18876405 chr7:65276391 NA -0.59 -7.87 -0.44 9.35e-14 Aortic root size; CESC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg08704250 chr15:31115839 NA -0.68 -9.12 -0.49 1.97e-17 Huntington's disease progression; CESC cis rs1707322 0.928 rs10732844 chr1:46372688 T/C cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7116495 0.867 rs510925 chr11:71809500 C/T cg10381502 chr11:71823885 C11orf51 0.97 6.26 0.36 1.54e-9 Severe influenza A (H1N1) infection; CESC trans rs561341 1.000 rs498391 chr17:30328704 G/A cg20587970 chr11:113659929 NA -1.34 -17.07 -0.72 1.45e-44 Hip circumference adjusted for BMI; CESC cis rs80130819 0.748 rs987986 chr12:48645427 C/G cg05342945 chr12:48394962 COL2A1 -0.54 -5.65 -0.33 4.16e-8 Prostate cancer; CESC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg08859206 chr1:53392774 SCP2 0.64 9.27 0.49 6.88e-18 Monocyte count; CESC cis rs17376456 1.000 rs9968691 chr5:93509756 C/G cg25358565 chr5:93447407 FAM172A 1.18 11.54 0.58 3.22e-25 Diabetic retinopathy; CESC cis rs910316 1.000 rs175512 chr14:75523382 T/C cg11812906 chr14:75593930 NEK9 -0.91 -15.62 -0.69 1.87e-39 Height; CESC cis rs3733585 0.699 rs17245723 chr4:9962218 A/T cg00071950 chr4:10020882 SLC2A9 -0.73 -11.83 -0.59 3.28e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs656900 0.647 rs898436 chr15:80117132 C/T cg02196730 chr15:80188777 MTHFS -0.39 -5.05 -0.3 8.31e-7 Cerebrospinal P-tau181p levels; CESC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg12311346 chr5:56204834 C5orf35 -0.74 -8.76 -0.47 2.43e-16 Initial pursuit acceleration; CESC cis rs2072499 0.966 rs6427304 chr1:156156789 A/G cg25208724 chr1:156163844 SLC25A44 0.98 17.44 0.73 6.76e-46 Testicular germ cell tumor; CESC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg25036284 chr2:26402008 FAM59B -0.58 -6.64 -0.38 1.8e-10 Gut microbiome composition (summer); CESC cis rs7598759 0.588 rs6737291 chr2:232329559 T/C cg19187155 chr2:232395269 NMUR1 0.4 6.27 0.36 1.49e-9 Noise-induced hearing loss; CESC cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg10578991 chr7:12443926 VWDE -0.56 -6.0 -0.35 6.36e-9 Coronary artery disease; CESC cis rs8062405 1.000 rs55830740 chr16:28847149 G/C cg08761264 chr16:28874980 SH2B1 -0.46 -5.77 -0.33 2.26e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6754311 0.681 rs4954493 chr2:136609975 T/C cg15123519 chr2:136567270 LCT 0.31 5.16 0.3 4.81e-7 Mosquito bite size; CESC cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.3 0.31 2.38e-7 Colonoscopy-negative controls vs population controls; CESC cis rs539096 0.500 rs2906457 chr1:44338575 A/C cg23954153 chr1:44402353 ARTN -0.35 -5.53 -0.32 7.68e-8 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05797001 chr16:75681577 KARS;TERF2IP -0.54 -6.11 -0.35 3.56e-9 Gut microbiome composition (summer); CESC cis rs9325144 0.505 rs1906262 chr12:38653605 A/G cg26384229 chr12:38710491 ALG10B 0.68 10.94 0.56 3.21e-23 Morning vs. evening chronotype; CESC cis rs8092503 0.536 rs12962378 chr18:52431095 T/C cg12377874 chr18:52495404 RAB27B 0.35 5.15 0.3 4.97e-7 Childhood body mass index; CESC cis rs4919687 0.550 rs10748828 chr10:104456794 C/T cg04362960 chr10:104952993 NT5C2 -0.42 -5.06 -0.3 8.01e-7 Colorectal cancer; CESC cis rs2625529 0.526 rs11634622 chr15:72562327 G/A cg16672083 chr15:72433130 SENP8 0.43 6.46 0.37 4.88e-10 Red blood cell count; CESC cis rs6580649 0.941 rs17122611 chr12:48458149 C/T cg24011408 chr12:48396354 COL2A1 -0.42 -5.28 -0.31 2.67e-7 Lung cancer; CESC cis rs3741798 1.000 rs3741798 chr12:12496086 C/T cg08615371 chr12:12503544 MANSC1 0.79 5.65 0.33 4.22e-8 Cerebrospinal fluid biomarker levels; CESC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg23161317 chr6:28129485 ZNF389 0.45 6.04 0.35 5.1e-9 Depression; CESC cis rs3747547 0.642 rs7018923 chr9:38088027 C/T cg13774184 chr9:37916125 SHB -0.61 -5.27 -0.31 2.8e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg23708337 chr7:1209742 NA 0.55 5.58 0.32 5.91e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22314900 chr2:109150331 NA -0.42 -6.01 -0.35 5.96e-9 Gambling; CESC cis rs1707322 1.000 rs1588663 chr1:46548825 G/A cg06784218 chr1:46089804 CCDC17 -0.33 -5.57 -0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg12463550 chr7:65579703 CRCP -0.45 -5.83 -0.34 1.63e-8 Aortic root size; CESC cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg01181863 chr3:195395398 SDHAP2 0.51 6.15 0.35 2.86e-9 Pancreatic cancer; CESC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg09177884 chr7:1199841 ZFAND2A -0.56 -7.25 -0.41 4.61e-12 Longevity;Endometriosis; CESC cis rs8008758 1.000 rs8013718 chr14:101689506 C/T cg26224664 chr14:101693935 NA -0.36 -5.3 -0.31 2.45e-7 Body mass index (alcohol intake interaction); CESC cis rs2742417 0.624 rs2742394 chr3:45757591 C/T cg04837898 chr3:45731254 SACM1L -0.48 -6.55 -0.37 2.96e-10 Response to anti-depressant treatment in major depressive disorder; CESC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg26314531 chr2:26401878 FAM59B -0.85 -9.04 -0.49 3.46e-17 Gut microbiome composition (summer); CESC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 13.1 0.63 1.4e-30 Platelet count; CESC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg17949981 chr6:28129498 ZNF389 0.42 5.2 0.3 3.96e-7 Parkinson's disease; CESC cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg18512352 chr11:47633146 NA -0.52 -7.51 -0.42 9.24e-13 Subjective well-being; CESC cis rs6456156 0.774 rs6931530 chr6:167527200 A/C cg07741184 chr6:167504864 NA -0.31 -5.21 -0.31 3.71e-7 Primary biliary cholangitis; CESC cis rs698833 0.509 rs1946932 chr2:44543125 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.53 5.26 0.31 2.97e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs897984 0.762 rs897986 chr16:30980902 T/C cg02466173 chr16:30829666 NA 0.47 7.79 0.43 1.48e-13 Dementia with Lewy bodies; CESC cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg20476274 chr7:133979776 SLC35B4 0.58 8.1 0.45 1.98e-14 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15774864 chr2:63272214 LOC100132215;EHBP1 0.46 6.07 0.35 4.37e-9 Fibrinogen levels; CESC cis rs4969178 0.965 rs3817294 chr17:76396963 A/G cg05887092 chr17:76393375 PGS1 0.58 9.22 0.49 9.9e-18 HDL cholesterol levels; CESC cis rs72781680 1.000 rs11553491 chr2:24225901 G/C cg08917208 chr2:24149416 ATAD2B 1.02 8.9 0.48 9.29e-17 Lymphocyte counts; CESC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg06873352 chr17:61820015 STRADA 0.72 12.95 0.62 4.84e-30 Prudent dietary pattern; CESC cis rs3126085 0.935 rs41267154 chr1:152286367 C/A cg03465714 chr1:152285911 FLG 0.5 5.71 0.33 2.96e-8 Atopic dermatitis; CESC cis rs9308433 0.529 rs9430133 chr1:214496313 C/T cg06198575 chr1:214491504 SMYD2 0.49 5.98 0.34 7.22e-9 IgG glycosylation; CESC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg02725872 chr8:58115012 NA -0.38 -5.1 -0.3 6.54e-7 Developmental language disorder (linguistic errors); CESC cis rs17376456 0.597 rs1031423 chr5:93276883 A/G cg25358565 chr5:93447407 FAM172A -0.44 -5.15 -0.3 4.97e-7 Diabetic retinopathy; CESC cis rs17102884 0.506 rs4899541 chr14:75403437 T/G cg08847533 chr14:75593920 NEK9 -0.44 -5.49 -0.32 9.41e-8 Neuroticism; CESC cis rs2243480 0.803 rs36004293 chr7:65416512 T/C cg18252515 chr7:66147081 NA -1.05 -10.01 -0.52 3.2e-20 Diabetic kidney disease; CESC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Parkinson's disease; CESC cis rs7264396 0.635 rs6058365 chr20:34508092 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.59 7.06 0.4 1.46e-11 Total cholesterol levels; CESC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 19.14 0.76 7.08e-52 Prudent dietary pattern; CESC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg12311346 chr5:56204834 C5orf35 -0.42 -5.28 -0.31 2.64e-7 Coronary artery disease; CESC cis rs7772486 0.875 rs2474356 chr6:146296798 G/A cg23711669 chr6:146136114 FBXO30 0.89 13.0 0.62 3.19e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs12348691 0.503 rs7848950 chr9:100612774 T/C cg13688889 chr9:100608707 NA -0.89 -13.65 -0.64 1.79e-32 Alopecia areata; CESC cis rs6088590 0.648 rs6059991 chr20:33280836 C/T cg08999081 chr20:33150536 PIGU 0.66 10.69 0.55 2.02e-22 Coronary artery disease; CESC cis rs4268898 0.662 rs72793208 chr2:24510284 C/T cg06627628 chr2:24431161 ITSN2 -0.97 -11.12 -0.56 7.81e-24 Asthma; CESC cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg06634786 chr22:41940651 POLR3H -0.68 -6.84 -0.39 5.59e-11 Vitiligo; CESC cis rs12479064 0.724 rs3087403 chr2:100058870 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -7.48 -0.42 1.07e-12 Chronic sinus infection; CESC cis rs4704187 0.687 rs10214239 chr5:74357475 G/A cg03227963 chr5:74354835 NA 0.29 5.31 0.31 2.34e-7 Response to amphetamines; CESC cis rs9814567 1.000 rs2177601 chr3:134245434 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs16866061 1.000 rs4674916 chr2:225365635 C/A cg12698349 chr2:225449008 CUL3 0.74 11.27 0.57 2.5e-24 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs3815700 0.844 rs444089 chr19:33106991 G/C cg24916020 chr19:33096688 ANKRD27 0.59 5.72 0.33 2.86e-8 Eosinophilic esophagitis; CESC cis rs7212590 0.748 rs55794618 chr17:57934337 G/C cg20303301 chr17:57937339 TUBD1 -0.58 -5.68 -0.33 3.47e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs9309473 1.000 rs11899902 chr2:73631564 G/A cg20560298 chr2:73613845 ALMS1 -0.5 -6.65 -0.38 1.69e-10 Metabolite levels; CESC cis rs6088580 0.602 rs6058064 chr20:33086622 A/G cg08999081 chr20:33150536 PIGU 0.65 11.38 0.57 1.04e-24 Glomerular filtration rate (creatinine); CESC cis rs9790314 0.967 rs336541 chr3:161056698 A/C cg04691961 chr3:161091175 C3orf57 -0.4 -5.11 -0.3 6.05e-7 Morning vs. evening chronotype; CESC cis rs2230307 0.536 rs526128 chr1:100473427 T/A cg24955406 chr1:100503596 HIAT1 0.55 5.48 0.32 9.85e-8 Carotid intima media thickness; CESC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg17294928 chr15:75287854 SCAMP5 0.51 6.71 0.38 1.2e-10 Breast cancer; CESC cis rs9355610 0.609 rs7772112 chr6:167408896 G/A cg23791538 chr6:167370224 RNASET2 0.54 6.37 0.36 8.26e-10 Graves' disease; CESC cis rs7542091 0.704 rs4133950 chr1:210044393 C/G cg22029157 chr1:209979665 IRF6 0.5 7.86 0.43 9.93e-14 Monobrow; CESC cis rs7223966 1.000 rs11870797 chr17:61804622 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.68 0.38 1.4e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg08859206 chr1:53392774 SCP2 -0.58 -7.44 -0.42 1.45e-12 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13064004 chr8:38854350 ADAM9;TM2D2 0.63 7.37 0.41 2.22e-12 Gut microbiome composition (summer); CESC cis rs7044106 0.734 rs10491784 chr9:123432289 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 12.82 0.62 1.3e-29 Hip circumference adjusted for BMI; CESC cis rs11622475 1.000 rs11622475 chr14:104509076 C/T cg12183467 chr14:104352244 NA -0.39 -5.53 -0.32 7.8e-8 Bipolar disorder; CESC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs67311347 0.955 rs12487955 chr3:40412853 T/C cg24209194 chr3:40518798 ZNF619 0.42 5.25 0.31 3.15e-7 Renal cell carcinoma; CESC cis rs7772486 0.654 rs6928007 chr6:146074941 G/A cg05347473 chr6:146136440 FBXO30 -0.52 -6.94 -0.39 3.01e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs738322 0.967 rs133017 chr22:38572637 A/C cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg00149659 chr3:10157352 C3orf10 0.75 9.42 0.5 2.25e-18 Alzheimer's disease; CESC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg22307029 chr19:49891270 CCDC155 0.62 7.3 0.41 3.29e-12 Multiple sclerosis; CESC cis rs16867321 0.950 rs2887180 chr2:181449305 C/A cg23363182 chr2:181467187 NA -0.43 -5.29 -0.31 2.61e-7 Obesity; CESC cis rs17431357 1.000 rs73230322 chr12:121010885 G/A cg25045489 chr12:120971538 RNF10 -0.92 -5.43 -0.32 1.27e-7 Insulin resistance/response; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13305165 chr3:25831802 NGLY1;OXSM -0.55 -6.55 -0.37 3.03e-10 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg22823121 chr1:150693482 HORMAD1 0.46 6.39 0.37 7.43e-10 Tonsillectomy; CESC cis rs60154123 0.554 rs1338290 chr1:210465467 G/A cg23283495 chr1:209979779 IRF6 0.42 5.41 0.32 1.41e-7 Coronary artery disease; CESC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg06873352 chr17:61820015 STRADA 0.73 12.89 0.62 7.87e-30 Prudent dietary pattern; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26069066 chr20:44044698 PIGT -0.46 -6.11 -0.35 3.45e-9 Ulcerative colitis; CESC cis rs11828289 0.660 rs12099049 chr11:23219311 A/G cg20040320 chr11:23191996 NA -0.71 -5.95 -0.34 8.63e-9 Cancer; CESC cis rs7851660 0.809 rs10984253 chr9:100664474 A/G cg13688889 chr9:100608707 NA -0.63 -8.95 -0.48 6.33e-17 Strep throat; CESC cis rs11997175 0.646 rs4593495 chr8:33692649 C/T ch.8.33884649F chr8:33765107 NA 0.56 7.33 0.41 2.73e-12 Body mass index; CESC cis rs12325245 0.536 rs35432891 chr16:58561966 G/A cg02549819 chr16:58548995 SETD6 0.96 6.42 0.37 6.42e-10 Schizophrenia; CESC cis rs7542091 0.704 rs4133950 chr1:210044393 C/G cg23283495 chr1:209979779 IRF6 0.35 5.69 0.33 3.41e-8 Monobrow; CESC cis rs6582630 0.519 rs11514372 chr12:38308613 T/G cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.23e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs6460942 0.597 rs7811374 chr7:12517437 T/C cg02935154 chr7:12443704 VWDE -0.54 -5.44 -0.32 1.23e-7 Coronary artery disease; CESC cis rs4660306 0.614 rs1765711 chr1:45936285 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.2 0.3 3.91e-7 Homocysteine levels; CESC cis rs1707322 0.721 rs10890341 chr1:46147240 C/A cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8058578 1.000 rs67128646 chr16:30672097 A/C cg02466173 chr16:30829666 NA -0.48 -7.34 -0.41 2.56e-12 Multiple myeloma; CESC cis rs854765 0.583 rs7222480 chr17:17818817 G/T cg16928487 chr17:17741425 SREBF1 -0.59 -10.25 -0.53 5.56e-21 Total body bone mineral density; CESC cis rs644799 1.000 rs525404 chr11:95566520 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.37 0.36 8.52e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg27125505 chr17:43679177 LOC644172 0.53 7.03 0.4 1.75e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4950928 0.823 rs4950929 chr1:203160126 A/C cg14085262 chr1:203155938 CHI3L1 0.47 5.27 0.31 2.83e-7 YKL-40 levels; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg22129074 chr11:74204105 LIPT2 0.49 6.5 0.37 3.97e-10 Obesity-related traits; CESC cis rs6940638 0.662 rs7759694 chr6:27240956 C/T cg12292205 chr6:26970375 C6orf41 -0.38 -5.23 -0.31 3.45e-7 Intelligence (multi-trait analysis); CESC cis rs634534 0.622 rs552130 chr11:65732800 T/C cg04055107 chr11:65626734 MUS81;CFL1 0.43 5.37 0.31 1.75e-7 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 -0.73 -6.69 -0.38 1.32e-10 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17331554 chr14:105167820 INF2 -0.61 -7.35 -0.41 2.51e-12 Gut microbiome composition (summer); CESC cis rs8067545 0.532 rs12943904 chr17:20007567 G/C cg12073167 chr17:19770448 ULK2 -0.44 -5.28 -0.31 2.71e-7 Schizophrenia; CESC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg07157834 chr1:205819609 PM20D1 0.72 10.41 0.54 1.66e-21 Menarche (age at onset); CESC cis rs7937682 0.924 rs7924683 chr11:111555796 C/A cg09085632 chr11:111637200 PPP2R1B -1.02 -16.9 -0.72 5.47e-44 Primary sclerosing cholangitis; CESC cis rs9847710 0.733 rs2581790 chr3:53101780 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.32 -5.14 -0.3 5.32e-7 Ulcerative colitis; CESC cis rs10876993 0.855 rs1689604 chr12:58048304 T/C cg18357645 chr12:58087776 OS9 0.58 9.0 0.48 4.49e-17 Celiac disease or Rheumatoid arthritis; CESC cis rs854765 0.583 rs7222480 chr17:17818817 G/T cg09796270 chr17:17721594 SREBF1 0.46 6.39 0.37 7.35e-10 Total body bone mineral density; CESC cis rs75804782 0.580 rs72987332 chr2:239362529 G/T cg18131467 chr2:239335373 ASB1 -0.7 -5.56 -0.32 6.56e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs7551222 0.691 rs11240760 chr1:204547268 A/G cg20240347 chr1:204465584 NA -0.28 -5.66 -0.33 3.84e-8 Schizophrenia; CESC cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg22467129 chr15:76604101 ETFA 0.38 5.77 0.33 2.15e-8 Blood metabolite levels; CESC cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -9.19 -0.49 1.17e-17 Mean corpuscular volume; CESC cis rs1044826 0.642 rs2071388 chr3:139236683 C/T cg00490450 chr3:139108681 COPB2 -0.44 -5.35 -0.31 1.95e-7 Obesity-related traits; CESC cis rs7829975 0.714 rs4841040 chr8:8654527 T/C cg15556689 chr8:8085844 FLJ10661 0.5 6.37 0.36 8.51e-10 Mood instability; CESC cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.17e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg16339924 chr4:17578868 LAP3 0.83 10.64 0.55 2.91e-22 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 1.000 rs3885839 chr7:65290403 G/T cg12463550 chr7:65579703 CRCP 0.69 5.53 0.32 7.48e-8 Diabetic kidney disease; CESC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.15 0.3 5.1e-7 Life satisfaction; CESC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg01411255 chr17:61851458 DDX42;CCDC47 1.01 15.49 0.69 5.85e-39 Height; CESC cis rs8114671 0.869 rs6060199 chr20:33654773 A/G cg24642439 chr20:33292090 TP53INP2 -0.47 -5.7 -0.33 3.19e-8 Height; CESC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg24250549 chr1:154909240 PMVK 0.58 7.82 0.43 1.26e-13 Prostate cancer; CESC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.49 -6.56 -0.37 2.79e-10 Personality dimensions; CESC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.38 -6.3 -0.36 1.23e-9 Bipolar disorder; CESC cis rs17209837 0.527 rs45479991 chr7:87083339 A/T cg00919237 chr7:87102261 ABCB4 -0.51 -6.58 -0.37 2.45e-10 Gallbladder cancer; CESC cis rs863345 0.604 rs4276920 chr1:158504972 G/C cg12129480 chr1:158549410 OR10X1 -0.35 -7.06 -0.4 1.45e-11 Pneumococcal bacteremia; CESC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg18876405 chr7:65276391 NA 0.56 7.49 0.42 1.03e-12 Aortic root size; CESC cis rs8077577 0.945 rs62073611 chr17:18071961 C/G cg16794390 chr17:18148240 FLII 0.44 5.47 0.32 1.06e-7 Obesity-related traits; CESC cis rs7772486 0.686 rs2179323 chr6:145982786 T/G cg23711669 chr6:146136114 FBXO30 -0.88 -13.1 -0.63 1.44e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs2439831 0.867 rs2255051 chr15:43846161 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.8 8.65 0.47 5.16e-16 Lung cancer in ever smokers; CESC cis rs7845219 0.525 rs3019175 chr8:95949013 G/A cg23172400 chr8:95962367 TP53INP1 -0.34 -6.12 -0.35 3.28e-9 Type 2 diabetes; CESC cis rs295140 0.585 rs4233996 chr2:201131228 A/T cg23649088 chr2:200775458 C2orf69 -0.44 -6.0 -0.35 6.56e-9 QT interval; CESC cis rs1348850 0.554 rs7595576 chr2:178371921 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.69 6.19 0.36 2.22e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg08704250 chr15:31115839 NA -0.63 -8.12 -0.45 1.82e-14 Huntington's disease progression; CESC cis rs965469 0.779 rs6037534 chr20:3269832 G/A cg25506879 chr20:3388711 C20orf194 -0.48 -5.29 -0.31 2.52e-7 IFN-related cytopenia; CESC cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg11366901 chr6:160182831 ACAT2 0.82 10.3 0.53 3.96e-21 Age-related macular degeneration (geographic atrophy); CESC cis rs9314614 0.934 rs2980955 chr8:6694434 A/G cg27319216 chr8:6693540 XKR5 -0.35 -5.12 -0.3 5.96e-7 IgA nephropathy;White blood cell count (basophil); CESC cis rs10751667 0.643 rs11246362 chr11:969818 C/T cg06064525 chr11:970664 AP2A2 -0.47 -9.23 -0.49 8.83e-18 Alzheimer's disease (late onset); CESC cis rs116095464 0.558 rs10055354 chr5:243794 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.63 -0.47 5.66e-16 Breast cancer; CESC cis rs3740713 1.000 rs74663287 chr11:18460300 T/C cg23797887 chr11:18477753 LDHAL6A -0.53 -5.11 -0.3 6.1e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg24675658 chr1:53192096 ZYG11B -0.48 -5.89 -0.34 1.16e-8 Monocyte count; CESC cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg22764044 chr5:178986830 RUFY1 0.41 5.61 0.33 4.96e-8 Lung cancer; CESC cis rs367943 0.712 rs26964 chr5:112738532 T/C cg12552261 chr5:112820674 MCC 0.41 5.43 0.32 1.28e-7 Type 2 diabetes; CESC cis rs7605827 0.930 rs6740183 chr2:15692583 T/C cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC cis rs7818688 0.578 rs11786451 chr8:95897031 T/G cg16049864 chr8:95962084 TP53INP1 0.49 5.06 0.3 7.8e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs919433 1.000 rs1429414 chr2:198162430 C/T cg10820045 chr2:198174542 NA -0.39 -5.73 -0.33 2.68e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9894429 0.789 rs9747336 chr17:79584189 C/T cg21984481 chr17:79567631 NPLOC4 -0.58 -9.48 -0.5 1.5e-18 Eye color traits; CESC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg10691866 chr7:65817282 TPST1 0.32 5.31 0.31 2.28e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18113596 chr7:57247912 LOC642006 -0.51 -7.42 -0.41 1.62e-12 Gut microbiome composition (summer); CESC cis rs12136530 0.744 rs34929465 chr1:19777950 G/A cg01832549 chr1:19774989 CAPZB -0.46 -6.78 -0.38 8e-11 Lead levels in blood; CESC cis rs734999 0.505 rs10910107 chr1:2539181 C/T cg20673091 chr1:2541236 MMEL1 0.45 7.79 0.43 1.5e-13 Ulcerative colitis; CESC cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6893300 0.776 rs55868831 chr5:179157296 T/C cg14593053 chr5:179126677 CANX -0.47 -5.15 -0.3 5.1e-7 Resting heart rate; CESC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg08736216 chr1:53307985 ZYG11A 0.43 7.23 0.41 5.32e-12 Monocyte count; CESC trans rs2417940 0.741 rs7313981 chr12:21012430 T/C cg19502417 chr1:21930336 RAP1GAP -0.46 -6.1 -0.35 3.71e-9 Bilirubin levels; CESC cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg07697082 chr8:82753677 SNX16 0.39 5.48 0.32 9.84e-8 Diastolic blood pressure; CESC cis rs9910055 0.529 rs425038 chr17:42182028 T/C cg13607699 chr17:42295918 UBTF -0.56 -7.15 -0.4 8.38e-12 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23567369 chr14:24036565 AP1G2 0.57 6.18 0.35 2.41e-9 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09172752 chr15:77197536 NA -0.53 -6.45 -0.37 5.14e-10 Ulcerative colitis; CESC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg02574844 chr11:5959923 NA -0.44 -6.6 -0.38 2.21e-10 DNA methylation (variation); CESC cis rs208520 1.000 rs12200490 chr6:66976084 G/A cg07460842 chr6:66804631 NA 0.89 10.27 0.53 4.85e-21 Exhaled nitric oxide output; CESC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg06494592 chr3:125709126 NA 0.46 5.03 0.3 8.94e-7 Blood pressure (smoking interaction); CESC cis rs7824557 0.564 rs2437152 chr8:11235497 G/A cg21775007 chr8:11205619 TDH -0.54 -8.1 -0.45 1.98e-14 Retinal vascular caliber; CESC cis rs9859260 0.710 rs419068 chr3:195782176 C/T cg12923728 chr3:195709715 SDHAP1 0.53 6.93 0.39 3.14e-11 Mean corpuscular volume; CESC cis rs1595825 0.891 rs73054825 chr2:198636355 G/C cg00982548 chr2:198649783 BOLL -0.47 -5.08 -0.3 7.12e-7 Ulcerative colitis; CESC cis rs9814567 1.000 rs7611828 chr3:134250325 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.15 -0.35 2.87e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs8067354 0.609 rs1292066 chr17:57932314 T/A cg13753209 chr17:57696993 CLTC 0.68 8.63 0.47 5.94e-16 Hemoglobin concentration; CESC cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg19748678 chr4:122722346 EXOSC9 0.72 9.42 0.5 2.39e-18 Type 2 diabetes; CESC trans rs61931739 0.500 rs11053199 chr12:34450534 C/T cg26384229 chr12:38710491 ALG10B -0.55 -7.76 -0.43 1.87e-13 Morning vs. evening chronotype; CESC cis rs4481887 0.927 rs6671702 chr1:248482851 G/A cg00666640 chr1:248458726 OR2T12 0.35 5.88 0.34 1.23e-8 Common traits (Other); CESC cis rs4423214 1.000 rs3794060 chr11:71187679 C/T cg05163923 chr11:71159392 DHCR7 0.8 10.72 0.55 1.69e-22 Vitamin D levels; CESC cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs34779708 0.897 rs4934529 chr10:35302376 T/A cg04310649 chr10:35416472 CREM -0.5 -5.98 -0.34 7.34e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9611565 0.659 rs17367849 chr22:41923644 G/A cg06634786 chr22:41940651 POLR3H -0.7 -7.47 -0.42 1.19e-12 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09473867 chr1:8763372 RERE 0.56 6.32 0.36 1.09e-9 Gut microbiome composition (summer); CESC cis rs1878931 0.580 rs4578649 chr16:3407258 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.92 -14.21 -0.66 1.82e-34 Body mass index (adult); CESC cis rs1620921 0.505 rs1344729 chr6:161204841 C/T cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg05872129 chr22:39784769 NA -0.81 -9.88 -0.52 8.3e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg21385522 chr1:16154831 NA 0.62 7.52 0.42 8.52e-13 Dilated cardiomyopathy; CESC trans rs1973993 0.689 rs17115225 chr1:96884330 C/T cg10631902 chr5:14652156 NA -0.49 -6.39 -0.37 7.58e-10 Weight; CESC cis rs2652822 0.525 rs8037296 chr15:63516759 A/G cg02713581 chr15:63449717 RPS27L 0.49 6.34 0.36 1e-9 Metabolic traits; CESC cis rs1878931 0.535 rs7188903 chr16:3412861 A/G cg02880119 chr16:3481970 NA -0.42 -5.34 -0.31 1.98e-7 Body mass index (adult); CESC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg25036284 chr2:26402008 FAM59B 0.56 6.68 0.38 1.43e-10 Gut microbiome composition (summer); CESC trans rs8073060 0.586 rs11080356 chr17:33895309 T/C cg19694781 chr19:47549865 TMEM160 0.69 6.76 0.38 8.98e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs826838 0.967 rs826879 chr12:39088999 A/C cg13010199 chr12:38710504 ALG10B -0.42 -5.95 -0.34 8.63e-9 Heart rate; CESC cis rs3096299 0.933 rs2965939 chr16:89493043 G/A cg00750074 chr16:89608354 SPG7 -0.4 -5.73 -0.33 2.71e-8 Multiple myeloma (IgH translocation); CESC cis rs1008375 0.966 rs4698638 chr4:17632988 G/C cg02297831 chr4:17616191 MED28 0.54 6.85 0.39 5.05e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC trans rs35160687 0.644 rs11127024 chr2:86505453 C/T ch.2.2367852R chr2:113497768 CKAP2L 0.48 6.0 0.35 6.48e-9 Night sleep phenotypes; CESC cis rs11864453 1.000 rs7185407 chr16:72034957 A/T cg01557791 chr16:72042693 DHODH 0.63 8.45 0.46 2.02e-15 Fibrinogen levels; CESC cis rs7666738 0.570 rs1869351 chr4:99077286 T/C cg05340658 chr4:99064831 C4orf37 0.65 9.19 0.49 1.17e-17 Colonoscopy-negative controls vs population controls; CESC cis rs6582630 0.563 rs923281 chr12:38590241 G/A cg26384229 chr12:38710491 ALG10B -0.42 -5.55 -0.32 7e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs10751667 1.000 rs7927156 chr11:970607 A/G cg06064525 chr11:970664 AP2A2 -0.33 -5.82 -0.34 1.71e-8 Alzheimer's disease (late onset); CESC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg15112475 chr7:1198522 ZFAND2A -0.37 -5.92 -0.34 1.02e-8 Longevity;Endometriosis; CESC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs3780486 0.846 rs10971438 chr9:33180308 A/G cg04842962 chr6:43655489 MRPS18A 0.85 12.49 0.61 1.81e-28 IgG glycosylation; CESC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg26314531 chr2:26401878 FAM59B -0.58 -6.54 -0.37 3.18e-10 Gut microbiome composition (summer); CESC cis rs4423214 1.000 rs11546509 chr11:71162785 A/G cg05163923 chr11:71159392 DHCR7 0.76 10.38 0.54 2.13e-21 Vitamin D levels; CESC cis rs796364 0.951 rs281769 chr2:200809709 T/C cg23649088 chr2:200775458 C2orf69 0.54 5.33 0.31 2.13e-7 Schizophrenia; CESC cis rs16866061 0.515 rs114968850 chr2:225352461 C/G cg12698349 chr2:225449008 CUL3 0.83 14.59 0.67 8.47e-36 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs3858526 0.834 rs7129481 chr11:5991114 G/T cg13902645 chr11:5959945 NA -0.49 -5.74 -0.33 2.52e-8 DNA methylation (variation); CESC trans rs1814175 0.817 rs7483795 chr11:49704930 G/A cg15704280 chr7:45808275 SEPT13 -1.04 -19.78 -0.77 4.33e-54 Height; CESC cis rs12541635 0.639 rs1032545 chr8:107005825 C/T cg10147462 chr8:107024639 NA 0.45 6.72 0.38 1.13e-10 Age of smoking initiation; CESC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs11214589 0.905 rs10891539 chr11:113236492 G/C cg14159747 chr11:113255604 NA 0.28 5.04 0.3 8.51e-7 Neuroticism; CESC cis rs1514687 0.534 rs73908736 chr2:1465401 C/T cg13703866 chr2:1479523 TPO -0.85 -5.58 -0.32 6e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg04772025 chr11:68637568 NA 0.5 5.99 0.35 6.85e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7937682 1.000 rs10502147 chr11:111569931 G/A cg22437258 chr11:111473054 SIK2 -0.68 -7.83 -0.43 1.19e-13 Primary sclerosing cholangitis; CESC cis rs2996428 0.536 rs12126653 chr1:3773815 C/G cg13057898 chr1:3703894 LRRC47 0.45 6.09 0.35 4e-9 Red cell distribution width; CESC trans rs507080 0.922 rs654792 chr11:118552996 A/C cg02280908 chr2:28615925 FOSL2 0.44 6.02 0.35 5.8e-9 Serum metabolite levels; CESC cis rs2070997 0.756 rs2987903 chr9:133711263 G/A cg11464064 chr9:133710261 ABL1 0.59 5.82 0.34 1.65e-8 Response to amphetamines; CESC cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg10691866 chr7:65817282 TPST1 0.33 5.52 0.32 8.13e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12241299 chr14:20929705 TMEM55B -0.62 -7.34 -0.41 2.64e-12 Gut microbiome composition (summer); CESC cis rs734999 0.588 rs3748819 chr1:2524966 C/T cg18854424 chr1:2615690 NA 0.27 5.14 0.3 5.31e-7 Ulcerative colitis; CESC cis rs8072100 0.790 rs3760371 chr17:45695914 T/C cg08085267 chr17:45401833 C17orf57 0.47 5.8 0.34 1.89e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2243480 1.000 rs313824 chr7:65581207 C/T cg13147721 chr7:65941812 NA -0.99 -9.36 -0.5 3.5e-18 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20299458 chr4:62383146 LPHN3 -0.61 -7.49 -0.42 1.04e-12 Gut microbiome composition (summer); CESC cis rs6674176 0.561 rs12127226 chr1:44395309 C/T cg12908607 chr1:44402522 ARTN -0.51 -7.54 -0.42 7.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7208859 0.524 rs57670615 chr17:29069498 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg11941060 chr3:133502564 NA -0.48 -6.21 -0.36 2.02e-9 Iron status biomarkers; CESC cis rs2243480 0.522 rs73150635 chr7:65972490 C/T cg18252515 chr7:66147081 NA -1.29 -9.61 -0.51 5.87e-19 Diabetic kidney disease; CESC cis rs1018836 0.923 rs7013893 chr8:91563137 G/A cg16814680 chr8:91681699 NA -0.69 -9.68 -0.51 3.67e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00176896 chr8:1185355 NA 0.39 6.79 0.38 7.43e-11 Gambling; CESC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg19163074 chr7:65112434 INTS4L2 0.43 5.44 0.32 1.24e-7 Aortic root size; CESC cis rs6426558 0.537 rs12139758 chr1:227260519 A/G cg10327440 chr1:227177885 CDC42BPA 0.46 5.68 0.33 3.52e-8 Neutrophil percentage of white cells; CESC cis rs8111998 0.826 rs7247524 chr19:22764213 C/A cg19914732 chr19:22715077 NA -0.37 -5.09 -0.3 6.68e-7 Corneal structure; CESC cis rs11098499 0.909 rs7681214 chr4:120385320 C/A cg24375607 chr4:120327624 NA 0.44 5.48 0.32 9.91e-8 Corneal astigmatism; CESC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 6.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg20243544 chr17:37824526 PNMT -0.49 -6.09 -0.35 3.9e-9 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27199523 chr6:139094722 CCDC28A -0.66 -7.24 -0.41 5e-12 Gut microbiome composition (summer); CESC cis rs35110281 0.591 rs189094 chr21:44932017 A/G cg01579765 chr21:45077557 HSF2BP -0.5 -8.14 -0.45 1.6e-14 Mean corpuscular volume; CESC cis rs6084875 0.733 rs4143674 chr20:4741304 T/C cg05143360 chr20:4741328 NA 0.56 7.56 0.42 6.51e-13 Systemic lupus erythematosus; CESC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg18479299 chr3:125709523 NA -0.48 -5.29 -0.31 2.61e-7 Blood pressure (smoking interaction); CESC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg27125505 chr17:43679177 LOC644172 0.49 6.75 0.38 9.18e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1881797 0.872 rs12404733 chr1:247690417 A/C cg05639522 chr1:247681581 NA 0.42 5.77 0.33 2.18e-8 Acute lymphoblastic leukemia (childhood); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17497049 chr19:56110871 FIZ1;ZNF524 -0.48 -6.18 -0.35 2.42e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1018836 0.828 rs7816023 chr8:91567398 T/C cg16814680 chr8:91681699 NA -0.63 -9.25 -0.49 7.74e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs61931739 0.534 rs11053049 chr12:34164537 T/C cg19457237 chr12:34500585 NA -0.39 -5.33 -0.31 2.08e-7 Morning vs. evening chronotype; CESC cis rs734999 0.545 rs28532547 chr1:2561286 T/G cg18854424 chr1:2615690 NA -0.3 -5.83 -0.34 1.62e-8 Ulcerative colitis; CESC cis rs1448094 0.813 rs6539942 chr12:86452969 T/C cg02569458 chr12:86230093 RASSF9 -0.34 -5.1 -0.3 6.54e-7 Major depressive disorder; CESC cis rs11785400 0.928 rs10100287 chr8:143734836 C/T cg10596483 chr8:143751796 JRK 0.42 5.4 0.31 1.49e-7 Schizophrenia; CESC cis rs1062753 0.961 rs9620007 chr22:42405657 C/G cg22189786 chr22:42395067 WBP2NL 0.43 5.43 0.32 1.26e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs58785573 0.504 rs13151185 chr4:38609196 G/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.53 7.34 0.41 2.65e-12 Lymphocyte percentage of white cells; CESC cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg23711669 chr6:146136114 FBXO30 -0.96 -14.81 -0.67 1.49e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg11890956 chr21:40555474 PSMG1 1.19 22.43 0.81 3.59e-63 Cognitive function; CESC cis rs9457247 0.510 rs6456151 chr6:167471851 A/C cg23791538 chr6:167370224 RNASET2 -0.5 -6.44 -0.37 5.46e-10 Crohn's disease; CESC cis rs10791097 0.547 rs3829271 chr11:130753912 T/A cg12179176 chr11:130786555 SNX19 0.66 10.15 0.53 1.12e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.63 -0.38 1.92e-10 Electroencephalogram traits; CESC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg17372223 chr3:52568218 NT5DC2 0.41 6.26 0.36 1.59e-9 Electroencephalogram traits; CESC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg18876405 chr7:65276391 NA -0.51 -7.19 -0.4 6.66e-12 Aortic root size; CESC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.44 -5.7 -0.33 3.24e-8 Tonsillectomy; CESC cis rs8060686 0.925 rs1134760 chr16:67964203 T/C cg26727032 chr16:67993705 SLC12A4 -0.58 -8.07 -0.44 2.39e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs12973672 1.000 rs8101606 chr19:35774556 A/C cg12095397 chr19:35769544 USF2 0.52 7.13 0.4 9.38e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14903832 chr2:198318098 COQ10B 0.64 7.25 0.41 4.49e-12 Gut microbiome composition (summer); CESC cis rs4834770 1.000 rs4834770 chr4:120241849 A/G cg09307838 chr4:120376055 NA 0.45 5.37 0.31 1.74e-7 Blood protein levels; CESC cis rs6570726 0.905 rs406799 chr6:145821837 G/C cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs637571 0.726 rs689274 chr11:65665988 A/G cg17712092 chr4:129076599 LARP1B -0.75 -10.22 -0.53 6.83e-21 Eosinophil percentage of white cells; CESC trans rs2321882 0.958 rs1413030 chr13:59395182 G/A cg20914879 chr14:56566808 NA -0.43 -6.17 -0.35 2.51e-9 Body mass index; CESC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg17724175 chr1:150552817 MCL1 0.33 5.23 0.31 3.49e-7 Melanoma; CESC cis rs7336332 0.598 rs1885989 chr13:28010117 G/A cg01674679 chr13:27998804 GTF3A -0.59 -5.36 -0.31 1.82e-7 Weight; CESC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg18190219 chr22:46762943 CELSR1 -0.58 -6.66 -0.38 1.57e-10 LDL cholesterol;Cholesterol, total; CESC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg27494647 chr7:150038898 RARRES2 0.42 5.17 0.3 4.62e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs2991971 0.810 rs6657237 chr1:45920108 A/T cg24296786 chr1:45957014 TESK2 -0.6 -8.56 -0.47 9.12e-16 High light scatter reticulocyte count; CESC cis rs78456975 0.739 rs72776248 chr2:1521314 A/G cg01028140 chr2:1542097 TPO -0.54 -5.34 -0.31 2e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7772486 0.790 rs9376968 chr6:146180364 T/C cg23711669 chr6:146136114 FBXO30 0.89 13.12 0.63 1.21e-30 Lobe attachment (rater-scored or self-reported); CESC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg10053473 chr17:62856997 LRRC37A3 0.68 7.69 0.43 2.94e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs113835537 0.529 rs3816492 chr11:66297363 C/T cg24851651 chr11:66362959 CCS 0.52 6.05 0.35 4.92e-9 Airway imaging phenotypes; CESC cis rs1538970 0.816 rs868351 chr1:46009818 G/T cg05343316 chr1:45956843 TESK2 0.84 11.82 0.59 3.45e-26 Platelet count; CESC cis rs6493487 0.512 rs12911270 chr15:51166326 C/T cg02338191 chr15:51200825 AP4E1 0.6 5.49 0.32 9.32e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2243480 1.000 rs160655 chr7:65533214 T/C cg13147721 chr7:65941812 NA -0.93 -8.87 -0.48 1.1e-16 Diabetic kidney disease; CESC cis rs61931739 0.500 rs11053177 chr12:34412829 G/A cg06521331 chr12:34319734 NA -0.37 -5.12 -0.3 5.75e-7 Morning vs. evening chronotype; CESC cis rs910316 1.000 rs10146482 chr14:75574087 C/T cg11812906 chr14:75593930 NEK9 0.91 16.22 0.71 1.43e-41 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03241323 chr2:187454863 ITGAV 0.68 7.46 0.42 1.21e-12 Gut microbiome composition (summer); CESC cis rs10504073 0.647 rs55920380 chr8:50026353 G/A cg00325661 chr8:49890786 NA 0.59 8.45 0.46 2e-15 Blood metabolite ratios; CESC cis rs5753618 0.583 rs5753628 chr22:31860322 A/G cg02404636 chr22:31891804 SFI1 0.39 5.34 0.31 1.97e-7 Colorectal cancer; CESC cis rs1005277 0.522 rs289648 chr10:37971837 T/C cg25427524 chr10:38739819 LOC399744 -0.62 -9.03 -0.49 3.53e-17 Extrinsic epigenetic age acceleration; CESC trans rs10435719 0.867 rs62493601 chr8:11788307 C/T cg15556689 chr8:8085844 FLJ10661 0.51 6.32 0.36 1.09e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg13906792 chr15:75199810 C15orf17 0.35 5.31 0.31 2.33e-7 Breast cancer; CESC cis rs17001868 0.568 rs12484697 chr22:40736472 A/G cg07138101 chr22:40742427 ADSL -0.54 -5.12 -0.3 5.93e-7 Mammographic density (dense area); CESC trans rs61931739 0.500 rs7965421 chr12:34523624 G/T cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.31e-22 Morning vs. evening chronotype; CESC cis rs17376456 0.569 rs1026279 chr5:93209581 C/A cg21475434 chr5:93447410 FAM172A -0.5 -5.04 -0.3 8.56e-7 Diabetic retinopathy; CESC cis rs6076065 0.963 rs2424543 chr20:23389955 G/T cg11657817 chr20:23433608 CST11 0.34 5.24 0.31 3.24e-7 Facial morphology (factor 15, philtrum width); CESC cis rs34172651 0.917 rs200539 chr16:24735178 T/C cg06028605 chr16:24865363 SLC5A11 -0.43 -6.48 -0.37 4.38e-10 Intelligence (multi-trait analysis); CESC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg11663144 chr21:46675770 NA -0.55 -8.56 -0.47 9.52e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2066819 1.000 rs11171803 chr12:56718422 T/C cg26804944 chr12:56660921 COQ10A -0.85 -5.14 -0.3 5.39e-7 Psoriasis vulgaris; CESC cis rs4237845 0.788 rs1962047 chr12:58292707 G/A cg02175503 chr12:58329896 NA 0.63 7.83 0.43 1.14e-13 Intelligence (multi-trait analysis); CESC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg04369109 chr6:150039330 LATS1 -0.47 -6.42 -0.37 6.11e-10 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26792749 chr19:41816040 CCDC97 -0.48 -6.39 -0.37 7.47e-10 Fibrinogen levels; CESC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 4.97e-9 Prudent dietary pattern; CESC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg17747265 chr1:1875780 NA 0.43 6.8 0.39 7.1e-11 Body mass index; CESC cis rs1005224 1.000 rs1981898 chr14:76175565 C/A cg25116370 chr14:76127843 TTLL5;C14orf1 -0.42 -5.79 -0.34 1.97e-8 Large artery stroke; CESC cis rs2439831 0.764 rs2447193 chr15:43929733 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 8.59 0.47 7.81e-16 Lung cancer in ever smokers; CESC cis rs601339 1.000 rs2454722 chr12:123171218 A/G cg11919336 chr12:123188078 GPR109A 0.47 6.38 0.36 8.07e-10 Adiponectin levels; CESC cis rs4409675 0.576 rs6660899 chr1:28214281 G/C cg23691781 chr1:28212827 C1orf38 0.28 5.74 0.33 2.59e-8 Corneal astigmatism; CESC cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg07697082 chr8:82753677 SNX16 0.41 6.25 0.36 1.67e-9 Diastolic blood pressure; CESC cis rs77956314 0.515 rs4238051 chr12:117366299 A/G cg16111737 chr12:117408163 FBXW8 -0.48 -5.74 -0.33 2.61e-8 Subcortical brain region volumes;Hippocampal volume; CESC cis rs2637266 0.739 rs2439580 chr10:78423214 T/G cg18941641 chr10:78392320 NA 0.39 7.28 0.41 3.87e-12 Pulmonary function; CESC cis rs9349203 1 rs9349203 chr6:41893323 G/A cg08135965 chr6:41755394 TOMM6 0.37 5.07 0.3 7.6e-7 Menarche (age at onset); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09192333 chr22:38142150 TRIOBP 0.45 6.0 0.35 6.54e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs17508449 0.865 rs75296543 chr1:114138286 C/A cg23028848 chr11:57092561 TNKS1BP1 -0.79 -6.26 -0.36 1.54e-9 Leprosy; CESC cis rs3820068 0.705 rs4646077 chr1:15827136 C/T cg17385448 chr1:15911702 AGMAT 0.39 6.18 0.35 2.44e-9 Systolic blood pressure; CESC cis rs10789491 1.000 rs7547522 chr1:47179918 C/G cg15501359 chr1:47185051 KIAA0494 0.77 8.56 0.47 9.21e-16 Response to hepatitis C treatment; CESC cis rs2228479 0.850 rs62054257 chr16:89900195 G/A cg06558623 chr16:89946397 TCF25 1.12 8.22 0.45 9.28e-15 Skin colour saturation; CESC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg26850624 chr5:429559 AHRR -0.5 -6.8 -0.39 6.97e-11 Cystic fibrosis severity; CESC cis rs4664308 0.692 rs4233681 chr2:160960058 T/C cg03641300 chr2:160917029 PLA2R1 -0.44 -6.23 -0.36 1.86e-9 Idiopathic membranous nephropathy; CESC cis rs7267979 0.868 rs6138546 chr20:25216534 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.42 0.69 1.02e-38 Liver enzyme levels (alkaline phosphatase); CESC cis rs4268898 0.662 rs58971404 chr2:24403753 G/A cg20701182 chr2:24300061 SF3B14 0.73 7.32 0.41 3.02e-12 Asthma; CESC cis rs71403859 1.000 rs71403859 chr16:71640207 C/T cg08717414 chr16:71523259 ZNF19 -0.79 -6.93 -0.39 3.19e-11 Post bronchodilator FEV1; CESC trans rs9329221 0.521 rs4841294 chr8:10105068 G/T cg15556689 chr8:8085844 FLJ10661 -0.5 -6.11 -0.35 3.54e-9 Neuroticism; CESC cis rs6545883 0.965 rs778752 chr2:61776902 C/G cg15711740 chr2:61764176 XPO1 -0.45 -5.7 -0.33 3.17e-8 Tuberculosis; CESC cis rs703842 1.000 rs10431505 chr12:58178589 A/G cg00677455 chr12:58241039 CTDSP2 0.53 6.97 0.39 2.55e-11 Multiple sclerosis; CESC cis rs17253792 0.822 rs58569951 chr14:56152245 T/C cg01858014 chr14:56050164 KTN1 -0.78 -6.61 -0.38 2.06e-10 Putamen volume; CESC cis rs7833986 0.534 rs2667980 chr8:56896541 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.16 0.4 8.04e-12 Height; CESC cis rs1044826 0.642 rs4683464 chr3:139196961 C/T cg00490450 chr3:139108681 COPB2 0.4 5.05 0.3 8.16e-7 Obesity-related traits; CESC cis rs11864453 0.611 rs1050361 chr16:72130203 C/G cg16558253 chr16:72132732 DHX38 -0.54 -8.44 -0.46 2.03e-15 Fibrinogen levels; CESC cis rs4594175 0.926 rs10873044 chr14:51615856 T/C cg23942311 chr14:51606299 NA 0.39 5.95 0.34 8.64e-9 Cancer; CESC cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg10845886 chr2:3471009 TTC15 -0.67 -9.24 -0.49 8.22e-18 Neurofibrillary tangles; CESC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg22105103 chr4:187893119 NA 0.51 7.69 0.43 2.88e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs2408955 0.521 rs10875749 chr12:48531917 T/A cg04545296 chr12:48745243 ZNF641 -0.33 -5.72 -0.33 2.85e-8 Glycated hemoglobin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18395393 chr17:8339079 NDEL1 0.59 6.47 0.37 4.62e-10 Gut microbiome composition (summer); CESC cis rs7927771 0.542 rs10769300 chr11:47865560 C/T cg20307385 chr11:47447363 PSMC3 0.63 8.77 0.47 2.17e-16 Subjective well-being; CESC cis rs6474412 1.000 rs6997909 chr8:42560249 A/G cg25026480 chr8:42547641 NA 0.32 5.09 0.3 6.85e-7 Smoking behavior; CESC trans rs9929218 0.954 rs12596834 chr16:68823199 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.13 -0.45 1.69e-14 Colorectal cancer; CESC cis rs796364 0.789 rs1653297 chr2:201075483 C/T cg23649088 chr2:200775458 C2orf69 0.49 5.65 0.33 4.21e-8 Schizophrenia; CESC cis rs8077577 0.895 rs11655797 chr17:18107850 C/T cg16794390 chr17:18148240 FLII 0.41 5.54 0.32 7.2e-8 Obesity-related traits; CESC cis rs782590 0.935 rs782649 chr2:55860308 T/C cg18811423 chr2:55921094 PNPT1 0.79 12.63 0.61 5.98e-29 Metabolic syndrome; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg27094323 chr7:1216898 NA -0.42 -5.97 -0.34 7.59e-9 Longevity;Endometriosis; CESC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.32 0.31 2.2e-7 Menopause (age at onset); CESC cis rs28374715 0.681 rs28687846 chr15:41599902 C/T cg18705301 chr15:41695430 NDUFAF1 -1.0 -14.25 -0.66 1.3600000000000001e-34 Ulcerative colitis; CESC cis rs61776719 0.520 rs12569027 chr1:38449163 C/T cg18451016 chr1:38461880 NA 0.42 6.33 0.36 1.04e-9 Coronary artery disease; CESC cis rs950169 0.920 rs11637666 chr15:84703874 A/G cg17507749 chr15:85114479 UBE2QP1 0.64 6.66 0.38 1.53e-10 Schizophrenia; CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg16145915 chr7:1198662 ZFAND2A -0.71 -11.4 -0.57 9.16e-25 Longevity;Endometriosis; CESC trans rs2898290 0.540 rs35005793 chr8:11450472 G/A cg15556689 chr8:8085844 FLJ10661 0.57 7.04 0.4 1.62e-11 Systolic blood pressure; CESC cis rs672059 1.000 rs522372 chr1:183157449 C/G ch.1.3577855R chr1:183094577 LAMC1 -0.54 -6.93 -0.39 3.12e-11 Hypertriglyceridemia; CESC cis rs6991838 0.584 rs10089708 chr8:66555162 T/C cg13398993 chr8:66546079 ARMC1 0.49 5.89 0.34 1.18e-8 Intelligence (multi-trait analysis); CESC cis rs7186908 0.711 rs9923344 chr16:72190653 T/C cg01557791 chr16:72042693 DHODH -0.64 -7.15 -0.4 8.33e-12 Liver enzyme levels (alkaline phosphatase); CESC cis rs4891159 0.790 rs11150953 chr18:74145491 G/A cg24786174 chr18:74118243 ZNF516 -0.72 -10.87 -0.56 5.42e-23 Longevity; CESC cis rs999943 0.846 rs2274200 chr6:33625696 T/C cg14003231 chr6:33640908 ITPR3 0.71 12.4 0.61 3.68e-28 Obesity (extreme); CESC cis rs9457247 0.765 rs1060404 chr6:167429467 A/G cg07741184 chr6:167504864 NA 0.36 6.54 0.37 3.11e-10 Crohn's disease; CESC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg04267008 chr7:1944627 MAD1L1 -0.58 -7.02 -0.4 1.89e-11 Bipolar disorder and schizophrenia; CESC cis rs4629180 1.000 rs908133 chr2:102092374 A/C cg04415270 chr2:102091202 RFX8 -0.41 -6.67 -0.38 1.5e-10 Chronic rhinosinusitis with nasal polyps; CESC cis rs2985684 0.841 rs12894785 chr14:50049755 G/C cg04989706 chr14:50066350 PPIL5 -0.46 -5.15 -0.3 5.04e-7 Carotid intima media thickness; CESC cis rs7927771 0.542 rs7122217 chr11:47777920 G/C cg18512352 chr11:47633146 NA -0.35 -5.47 -0.32 1.03e-7 Subjective well-being; CESC trans rs35110281 0.811 rs2838339 chr21:45075750 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.54 -7.09 -0.4 1.25e-11 Mean corpuscular volume; CESC cis rs3092073 0.624 rs7275164 chr20:44604822 G/A cg00981651 chr20:44574847 PCIF1 0.37 5.37 0.31 1.75e-7 Intelligence (multi-trait analysis); CESC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg26587870 chr6:27730563 NA -0.6 -5.29 -0.31 2.58e-7 Depression; CESC cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs733175 0.855 rs9291641 chr4:10007259 C/T cg00071950 chr4:10020882 SLC2A9 0.55 6.62 0.38 1.95e-10 Psychosis and Alzheimer's disease; CESC cis rs2011503 1.000 rs74950305 chr19:19639448 C/T cg11584989 chr19:19387371 SF4 0.61 7.03 0.4 1.79e-11 Bipolar disorder; CESC cis rs4689388 0.750 rs10001190 chr4:6284633 C/T cg14416269 chr4:6271139 WFS1 -0.42 -6.61 -0.38 2.08e-10 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs80130819 0.515 rs72644846 chr12:48508283 A/G cg05342945 chr12:48394962 COL2A1 0.55 6.32 0.36 1.13e-9 Prostate cancer; CESC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 11.77 0.59 5.44e-26 Platelet count; CESC cis rs7762018 1.000 rs6942332 chr6:170131934 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.55 5.56 0.32 6.5e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7772486 0.790 rs9497435 chr6:146265340 C/A cg23711669 chr6:146136114 FBXO30 -0.81 -11.61 -0.58 1.87e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs6987853 0.787 rs2923427 chr8:42385748 A/C cg09913449 chr8:42400586 C8orf40 0.45 7.62 0.42 4.55e-13 Mean corpuscular hemoglobin concentration; CESC cis rs1514687 0.534 rs11211654 chr2:1474131 C/T cg13703866 chr2:1479523 TPO -0.8 -6.32 -0.36 1.09e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs7903847 0.642 rs11189196 chr10:99155079 A/G cg20016023 chr10:99160130 RRP12 -0.3 -5.16 -0.3 4.77e-7 Granulocyte percentage of myeloid white cells; CESC cis rs7116495 0.609 rs949323 chr11:71714528 T/G cg10381502 chr11:71823885 C11orf51 -1.13 -7.93 -0.44 6.3e-14 Severe influenza A (H1N1) infection; CESC cis rs2708240 0.577 rs1177007 chr7:147546371 G/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.38 -5.76 -0.33 2.36e-8 QT interval (drug interaction); CESC cis rs933688 1.000 rs6452951 chr5:90653868 T/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.97 13.31 0.63 2.75e-31 Smoking behavior; CESC cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg25985355 chr7:65971099 NA -0.43 -5.58 -0.32 6.06e-8 Diabetic kidney disease; CESC cis rs12765878 1.000 rs2273698 chr10:105649158 G/A cg24587175 chr10:105670608 OBFC1 0.32 5.22 0.31 3.58e-7 Coronary artery disease; CESC cis rs7084402 0.967 rs1658423 chr10:60331627 T/G cg07615347 chr10:60278583 BICC1 0.56 8.39 0.46 2.91e-15 Refractive error; CESC cis rs9543976 1.000 rs2328964 chr13:76138830 G/T cg01531495 chr13:76123901 UCHL3 0.56 5.65 0.33 4.21e-8 Diabetic retinopathy; CESC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg22535103 chr8:58192502 C8orf71 -0.84 -9.44 -0.5 2.04e-18 Developmental language disorder (linguistic errors); CESC cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.04 9.88 0.52 8.25e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6089584 1.000 rs6089585 chr20:60564395 G/A cg24733560 chr20:60626293 TAF4 0.4 5.77 0.33 2.15e-8 Body mass index; CESC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg05332525 chr7:65337924 VKORC1L1 -0.48 -6.05 -0.35 4.86e-9 Calcium levels; CESC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.35e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7927592 0.956 rs12365160 chr11:68250419 A/G cg16797656 chr11:68205561 LRP5 0.39 5.47 0.32 1.06e-7 Total body bone mineral density; CESC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg19717773 chr7:2847554 GNA12 -0.63 -10.29 -0.53 3.97e-21 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs9513627 0.573 rs4771336 chr13:100210610 T/G cg15490075 chr13:100150979 NA 0.48 5.38 0.31 1.66e-7 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26548542 chr16:89177266 ACSF3 0.42 6.16 0.35 2.7e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12392475 chr5:140537692 PCDHB17 -0.49 -6.05 -0.35 4.84e-9 Gut microbiome composition (summer); CESC trans rs4108601 0.590 rs17868255 chr2:52030913 C/T cg02531768 chr10:521758 DIP2C -0.72 -6.14 -0.35 2.95e-9 Facial morphology (factor 19); CESC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg11247378 chr22:39784982 NA -0.63 -8.64 -0.47 5.22e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7680126 0.595 rs17251963 chr4:10142561 A/G cg00071950 chr4:10020882 SLC2A9 -0.49 -5.32 -0.31 2.23e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs72781680 0.611 rs72797810 chr2:24336469 G/A cg06627628 chr2:24431161 ITSN2 -0.67 -6.51 -0.37 3.7e-10 Lymphocyte counts; CESC trans rs35110281 0.591 rs162369 chr21:44931965 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.68 0.38 1.41e-10 Mean corpuscular volume; CESC cis rs6967385 0.704 rs17149929 chr7:12406080 A/T cg02935154 chr7:12443704 VWDE 0.32 5.05 0.3 8.25e-7 Response to taxane treatment (placlitaxel); CESC cis rs748404 0.560 rs570933 chr15:43824030 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.55 7.05 0.4 1.52e-11 Lung cancer; CESC cis rs950169 0.545 rs4842841 chr15:84641125 G/A cg17507749 chr15:85114479 UBE2QP1 0.62 5.98 0.34 7.21e-9 Schizophrenia; CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg17221315 chr6:27791827 HIST1H4J 0.43 5.03 0.3 9.18e-7 Depression; CESC trans rs11098499 0.657 rs4463052 chr4:120313258 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg16262614 chr3:133464971 TF 0.3 5.46 0.32 1.11e-7 Iron status biomarkers; CESC cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.64 7.51 0.42 9.22e-13 Multiple sclerosis; CESC cis rs3820068 0.603 rs72645900 chr1:15931980 A/T cg17385448 chr1:15911702 AGMAT 0.44 7.16 0.4 7.97e-12 Systolic blood pressure; CESC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg18402987 chr7:1209562 NA 0.73 7.13 0.4 9.84e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 11.37 0.57 1.12e-24 Platelet count; CESC cis rs6752107 0.967 rs6431661 chr2:234167421 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.4 6.04 0.35 5.16e-9 Crohn's disease;Inflammatory bowel disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25215298 chr1:860022 SAMD11 -0.38 -6.08 -0.35 4.12e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00602371 chr16:77233247 SYCE1L;MON1B -0.53 -6.09 -0.35 4.02e-9 Gut microbiome composition (summer); CESC cis rs9876781 0.559 rs11130167 chr3:48400060 A/G cg11946769 chr3:48343235 NME6 0.4 5.07 0.3 7.31e-7 Longevity; CESC cis rs2294693 0.891 rs9369256 chr6:40998344 G/C cg14418226 chr6:40996092 UNC5CL 0.55 6.8 0.39 6.93e-11 Gastric cancer;Non-cardia gastric cancer; CESC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg21770322 chr7:97807741 LMTK2 0.55 8.27 0.45 6.54e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs6987853 0.933 rs2974352 chr8:42408483 C/T cg09913449 chr8:42400586 C8orf40 0.4 6.38 0.37 7.72e-10 Mean corpuscular hemoglobin concentration; CESC cis rs67311347 0.826 rs9863679 chr3:40439614 G/A cg09455208 chr3:40491958 NA 0.5 8.24 0.45 8.07e-15 Renal cell carcinoma; CESC cis rs9815354 0.812 rs17283929 chr3:41941898 C/G cg03022575 chr3:42003672 ULK4 -0.7 -6.71 -0.38 1.16e-10 Pulse pressure;Diastolic blood pressure; CESC trans rs6445797 0.788 rs6445805 chr3:56670281 G/C cg15444621 chr13:113611794 NA 0.32 6.01 0.35 6.11e-9 Gastritis; CESC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg26752003 chr8:145688521 CYHR1 -0.59 -7.75 -0.43 1.93e-13 Age at first birth; CESC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg09323728 chr8:95962352 TP53INP1 -0.37 -7.92 -0.44 6.51e-14 Type 2 diabetes; CESC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg14338887 chr6:42928500 GNMT 0.35 5.08 0.3 7.25e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7223966 1.000 rs8068603 chr17:61755211 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.42 0.41 1.55e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg23048001 chr7:2026167 MAD1L1 -0.49 -6.39 -0.37 7.43e-10 Bipolar disorder and schizophrenia; CESC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg17724175 chr1:150552817 MCL1 -0.37 -5.66 -0.33 3.91e-8 Melanoma; CESC cis rs1003719 0.613 rs9978998 chr21:38535848 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.06 -0.44 2.72e-14 Eye color traits; CESC cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg02592271 chr2:27665507 KRTCAP3 -0.33 -6.41 -0.37 6.76e-10 Total body bone mineral density; CESC cis rs73058052 1.000 rs73057994 chr19:50091273 C/A cg09250473 chr19:50168907 IRF3;BCL2L12 0.59 5.74 0.33 2.55e-8 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12753558 chr1:247464072 ZNF496 -0.59 -6.21 -0.36 2e-9 Gut microbiome composition (summer); CESC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg23590916 chr17:43697445 MGC57346 0.65 6.68 0.38 1.38e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg13866156 chr1:1669148 SLC35E2 -0.51 -6.82 -0.39 6.21e-11 Body mass index; CESC cis rs7937682 0.924 rs10891288 chr11:111552053 G/T cg09085632 chr11:111637200 PPP2R1B 1.02 17.0 0.72 2.54e-44 Primary sclerosing cholangitis; CESC cis rs7647973 0.848 rs4955411 chr3:49145304 A/G cg06212747 chr3:49208901 KLHDC8B 0.55 6.36 0.36 8.72e-10 Menarche (age at onset); CESC cis rs9325144 0.505 rs7138977 chr12:38642109 G/A cg26384229 chr12:38710491 ALG10B 0.67 10.81 0.55 8.39e-23 Morning vs. evening chronotype; CESC cis rs6504663 0.558 rs11871603 chr17:48559037 T/G cg03611598 chr17:48586076 MYCBPAP 0.53 6.21 0.36 2.06e-9 Visceral fat; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03909886 chr10:42606808 NA 0.42 6.36 0.36 8.57e-10 Fibrinogen levels; CESC cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg00825309 chr19:58991885 ZNF446 -0.54 -7.71 -0.43 2.57e-13 Uric acid clearance; CESC cis rs7843479 0.582 rs7818254 chr8:21798316 C/T cg17168535 chr8:21777572 XPO7 0.74 12.35 0.6 5.77e-28 Mean corpuscular volume; CESC cis rs3947 0.950 rs1692811 chr8:11703048 C/G cg00262122 chr8:11665843 FDFT1 -0.5 -5.06 -0.3 7.67e-7 Blood protein levels; CESC trans rs11039798 0.588 rs7108164 chr11:48626363 A/C cg15704280 chr7:45808275 SEPT13 0.61 6.29 0.36 1.32e-9 Axial length; CESC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.69 6.12 0.35 3.41e-9 Platelet count; CESC cis rs9303401 0.659 rs62081315 chr17:56781468 T/C cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC cis rs1707322 1.000 rs11211248 chr1:46476844 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.7 0.33 3.15e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7116495 0.609 rs7121080 chr11:71703935 G/A cg26138937 chr11:71823887 C11orf51 -1.22 -8.09 -0.45 2.15e-14 Severe influenza A (H1N1) infection; CESC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg24829409 chr8:58192753 C8orf71 -0.67 -7.32 -0.41 3e-12 Developmental language disorder (linguistic errors); CESC cis rs3793683 0.520 rs4880426 chr10:134590610 G/A cg26818010 chr10:134567672 INPP5A -0.9 -11.23 -0.57 3.42e-24 Migraine; CESC cis rs7829975 0.593 rs2921051 chr8:8320104 C/A cg15556689 chr8:8085844 FLJ10661 0.61 8.16 0.45 1.35e-14 Mood instability; CESC cis rs2839186 0.605 rs2839173 chr21:47676711 G/A cg10351095 chr21:47802916 PCNT -0.48 -6.46 -0.37 5.11e-10 Testicular germ cell tumor; CESC cis rs1707322 0.721 rs6697821 chr1:46216722 A/G cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17376456 0.825 rs17374166 chr5:93238655 T/C cg21475434 chr5:93447410 FAM172A 0.78 6.83 0.39 5.85e-11 Diabetic retinopathy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23192255 chr4:1309340 MAEA 0.47 6.17 0.35 2.55e-9 Fibrinogen levels; CESC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg04166393 chr7:2884313 GNA12 0.59 7.48 0.42 1.12e-12 Height; CESC cis rs7647973 0.626 rs2329021 chr3:49679072 G/A cg07636037 chr3:49044803 WDR6 0.53 6.34 0.36 9.78e-10 Menarche (age at onset); CESC cis rs67311347 1.000 rs9865348 chr3:40397658 A/C cg09455208 chr3:40491958 NA 0.53 9.29 0.5 5.82e-18 Renal cell carcinoma; CESC cis rs3741404 1.000 rs3741404 chr11:63999240 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.92 13.92 0.65 2.01e-33 Platelet count; CESC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg04267008 chr7:1944627 MAD1L1 -0.72 -9.3 -0.5 5.53e-18 Bipolar disorder and schizophrenia; CESC cis rs2013441 1.000 rs11654025 chr17:20198160 A/T cg13482628 chr17:19912719 NA -0.39 -5.07 -0.3 7.58e-7 Obesity-related traits; CESC cis rs748404 0.631 rs12905772 chr15:43648444 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.64 0.43 3.88e-13 Lung cancer; CESC cis rs3540 0.597 rs12708583 chr15:91050271 C/T cg10434728 chr15:90938212 IQGAP1 0.41 7.61 0.42 4.69e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs250677 0.958 rs36070 chr5:148417240 T/C cg18129178 chr5:148520854 ABLIM3 -0.52 -5.8 -0.34 1.86e-8 Breast cancer; CESC cis rs9359856 0.600 rs17584763 chr6:90502088 G/A cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.58 -0.37 2.53e-10 Bipolar disorder; CESC cis rs60154123 0.505 rs76426571 chr1:210041634 C/T cg21951975 chr1:209979733 IRF6 0.58 6.23 0.36 1.85e-9 Coronary artery disease; CESC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg16325326 chr1:53192061 ZYG11B -0.89 -15.32 -0.69 2.26e-38 Monocyte count; CESC cis rs6748734 1.000 rs4311055 chr2:241821017 T/C cg07537917 chr2:241836409 C2orf54 -0.25 -5.35 -0.31 1.89e-7 Urinary metabolites; CESC cis rs3126085 0.935 rs1390488 chr1:152199500 T/C cg03465714 chr1:152285911 FLG -0.43 -5.24 -0.31 3.23e-7 Atopic dermatitis; CESC cis rs10870270 0.956 rs4880405 chr10:133787021 G/A cg08754478 chr10:133766260 PPP2R2D -0.6 -7.68 -0.43 3.03e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs11098499 0.604 rs10022185 chr4:120571765 C/G cg09307838 chr4:120376055 NA 0.76 9.58 0.51 7.28e-19 Corneal astigmatism; CESC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.79 13.24 0.63 4.57e-31 Personality dimensions; CESC cis rs6502050 0.635 rs11867440 chr17:80147185 A/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.58e-10 Life satisfaction; CESC cis rs1348850 0.914 rs7587604 chr2:178309848 T/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.75 10.72 0.55 1.7e-22 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs523522 0.962 rs3893104 chr12:120903936 G/A cg27279351 chr12:120934652 DYNLL1 0.69 8.69 0.47 3.82e-16 High light scatter reticulocyte count; CESC cis rs708547 0.575 rs6847086 chr4:57791864 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.49 -6.17 -0.35 2.59e-9 Response to bleomycin (chromatid breaks); CESC cis rs2425143 1.000 rs73905926 chr20:34251982 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -7.52 -0.42 8.7e-13 Blood protein levels; CESC cis rs9487051 0.582 rs351723 chr6:109545547 G/A cg01475377 chr6:109611718 NA -0.38 -5.18 -0.3 4.49e-7 Reticulocyte fraction of red cells; CESC cis rs11264213 0.901 rs72661608 chr1:36333850 C/G cg27506609 chr1:36549197 TEKT2 0.69 5.49 0.32 9.42e-8 Schizophrenia; CESC cis rs7224737 1.000 rs9889618 chr17:40293467 C/T cg20291162 chr17:40259547 DHX58 -0.4 -5.48 -0.32 9.96e-8 Fibrinogen levels; CESC cis rs7918232 0.943 rs6482593 chr10:27371437 A/G cg14442939 chr10:27389572 ANKRD26 0.7 6.63 0.38 1.87e-10 Breast cancer; CESC cis rs7818688 0.585 rs2678829 chr8:96028180 C/T cg16049864 chr8:95962084 TP53INP1 -0.6 -6.5 -0.37 3.9e-10 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg03709012 chr19:19516395 GATAD2A 1.01 15.71 0.69 9.73e-40 Tonsillectomy; CESC cis rs9581857 0.579 rs75872792 chr13:27996064 G/T cg01674679 chr13:27998804 GTF3A -0.67 -5.58 -0.32 5.88e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg08888203 chr3:10149979 C3orf24 0.47 6.03 0.35 5.4e-9 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05590361 chr11:68039700 C11orf24 0.59 6.26 0.36 1.58e-9 Gut microbiome composition (summer); CESC cis rs5167 0.566 rs204905 chr19:45460764 G/A cg20090143 chr19:45452003 APOC2 0.34 5.56 0.32 6.56e-8 Blood protein levels; CESC cis rs66530629 0.874 rs4562565 chr1:25121874 A/G cg22509179 chr1:25234806 RUNX3 -0.43 -5.43 -0.32 1.29e-7 Plateletcrit; CESC cis rs6503863 1 rs6503863 chr17:56517034 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.49 6.58 0.37 2.53e-10 Intelligence (multi-trait analysis); CESC cis rs7771547 0.573 rs629721 chr6:36398229 T/C cg04289385 chr6:36355825 ETV7 0.38 5.57 0.32 6.41e-8 Platelet distribution width; CESC cis rs6460942 0.915 rs62447638 chr7:12484667 G/A cg02935154 chr7:12443704 VWDE -0.56 -5.83 -0.34 1.61e-8 Coronary artery disease; CESC cis rs8078723 0.714 rs9915252 chr17:38145088 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.05 0.3 8.15e-7 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg18876405 chr7:65276391 NA 0.56 7.51 0.42 8.81e-13 Aortic root size; CESC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg26528311 chr1:38462546 FHL3 -0.34 -5.07 -0.3 7.4e-7 Coronary artery disease; CESC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 7.78 0.43 1.58e-13 Menopause (age at onset); CESC cis rs7904368 0.806 rs7099178 chr10:16862578 C/G cg23933602 chr10:16859644 RSU1 0.6 5.49 0.32 9.24e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs916888 0.773 rs169201 chr17:44790203 A/G cg01570182 chr17:44337453 NA 0.94 10.63 0.55 3.24e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg00149659 chr3:10157352 C3orf10 0.58 6.17 0.35 2.51e-9 Alzheimer's disease; CESC cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg01475377 chr6:109611718 NA -0.4 -6.22 -0.36 1.93e-9 Reticulocyte fraction of red cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01345365 chr2:12163619 NA -0.45 -6.65 -0.38 1.66e-10 Gut microbiota (bacterial taxa); CESC cis rs1153858 1.000 rs16942000 chr15:45633003 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs10905065 0.898 rs2892078 chr10:5831138 A/G cg11519256 chr10:5708881 ASB13 -0.41 -5.47 -0.32 1.04e-7 Menopause (age at onset); CESC cis rs79349575 0.745 rs170319 chr17:46991531 T/C cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs208515 0.592 rs10944862 chr6:66674215 C/T cg07460842 chr6:66804631 NA 0.86 10.87 0.56 5.19e-23 Exhaled nitric oxide levels; CESC cis rs7666738 0.791 rs34790496 chr4:98930516 C/T cg05340658 chr4:99064831 C4orf37 0.78 11.44 0.57 6.92e-25 Colonoscopy-negative controls vs population controls; CESC cis rs6964587 1.000 rs61244255 chr7:91751662 C/T cg17063962 chr7:91808500 NA 0.55 7.4 0.41 1.8e-12 Breast cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18462168 chr15:22892545 CYFIP1 0.43 6.07 0.35 4.5e-9 Systemic lupus erythematosus; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg01523285 chr1:52301876 NRD1 0.42 6.76 0.38 8.9e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg19592336 chr6:28129416 ZNF389 0.62 8.11 0.45 1.84e-14 Depression; CESC cis rs11696845 0.626 rs1111032 chr20:43378770 A/G cg25301532 chr20:43378953 KCNK15 0.39 6.23 0.36 1.87e-9 Obesity-related traits; CESC cis rs62103177 0.810 rs62103178 chr18:77624555 C/G cg12964065 chr18:77638022 KCNG2 0.58 5.46 0.32 1.07e-7 Opioid sensitivity; CESC cis rs9814567 1.000 rs13081688 chr3:134259954 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7809950 1.000 rs1544336 chr7:107082415 G/C cg23024343 chr7:107201750 COG5 -0.39 -5.51 -0.32 8.44e-8 Coronary artery disease; CESC cis rs79976124 0.837 rs10455591 chr6:66650584 A/G cg07460842 chr6:66804631 NA 0.75 8.81 0.48 1.64e-16 Type 2 diabetes; CESC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg14983838 chr19:29218262 NA 0.51 6.13 0.35 3.09e-9 Methadone dose in opioid dependence; CESC cis rs12579753 0.871 rs10862362 chr12:82199383 T/G cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.33 5.25 0.31 3.13e-7 Personality dimensions; CESC cis rs7833986 0.501 rs72653990 chr8:57037115 G/A cg26371346 chr8:56986568 SNORD54;RPS20 0.56 5.04 0.3 8.57e-7 Height; CESC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg08888203 chr3:10149979 C3orf24 0.53 6.83 0.39 5.8200000000000003e-11 Alzheimer's disease; CESC cis rs965513 1.000 rs7850258 chr9:100549013 C/T cg13688889 chr9:100608707 NA 0.57 7.94 0.44 5.82e-14 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg11890956 chr21:40555474 PSMG1 -0.93 -15.01 -0.68 2.9e-37 Cognitive function; CESC cis rs79349575 0.783 rs4255820 chr17:46996583 T/A cg16584676 chr17:46985605 UBE2Z 0.54 6.61 0.38 2.05e-10 Type 2 diabetes; CESC cis rs734999 0.545 rs28690427 chr1:2571823 A/G cg18854424 chr1:2615690 NA -0.3 -5.88 -0.34 1.2e-8 Ulcerative colitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26771998 chr10:75490334 BMS1P4 -0.39 -6.33 -0.36 1.04e-9 Gambling; CESC trans rs561341 0.843 rs4795666 chr17:30241409 A/G cg20587970 chr11:113659929 NA -0.76 -9.69 -0.51 3.33e-19 Hip circumference adjusted for BMI; CESC cis rs17376456 0.877 rs114256265 chr5:93473130 T/A cg25358565 chr5:93447407 FAM172A 1.17 11.51 0.58 3.92e-25 Diabetic retinopathy; CESC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg09323728 chr8:95962352 TP53INP1 -0.45 -9.86 -0.52 9.98e-20 Type 2 diabetes; CESC trans rs1814175 0.558 rs5025146 chr11:49795724 C/G cg15704280 chr7:45808275 SEPT13 -0.99 -17.52 -0.73 3.72e-46 Height; CESC cis rs7134594 0.714 rs7313056 chr12:109871458 T/C cg19025524 chr12:109796872 NA -0.39 -5.68 -0.33 3.61e-8 HDL cholesterol; CESC cis rs4253772 1.000 rs4253766 chr22:46623905 C/T cg00784671 chr22:46762841 CELSR1 -0.48 -5.28 -0.31 2.65e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7394190 0.748 rs78985317 chr10:75514465 C/T cg07699608 chr10:75541558 CHCHD1 0.65 5.35 0.31 1.87e-7 Incident atrial fibrillation; CESC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg05255149 chr17:80675120 FN3KRP -0.45 -5.15 -0.3 4.97e-7 Breast cancer; CESC cis rs854765 0.547 rs4365348 chr17:17912548 C/T cg04398451 chr17:18023971 MYO15A -0.68 -10.13 -0.53 1.34e-20 Total body bone mineral density; CESC cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.75 -11.08 -0.56 1.04e-23 Monocyte percentage of white cells; CESC cis rs17376456 0.825 rs10079708 chr5:93261796 G/C cg25358565 chr5:93447407 FAM172A 1.12 10.4 0.54 1.88e-21 Diabetic retinopathy; CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg07092213 chr7:1199455 ZFAND2A -0.43 -5.67 -0.33 3.72e-8 Longevity;Endometriosis; CESC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg27266027 chr21:40555129 PSMG1 0.43 5.25 0.31 3.2e-7 Cognitive function; CESC cis rs2880765 0.835 rs4514633 chr15:86041017 T/G cg19183879 chr15:85880815 NA -0.26 -5.34 -0.31 2.01e-7 Coronary artery disease; CESC cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg17911788 chr17:44343683 NA -0.53 -7.15 -0.4 8.49e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs36051895 0.632 rs2149552 chr9:5132838 A/G cg02405213 chr9:5042618 JAK2 -0.48 -6.01 -0.35 6.09e-9 Pediatric autoimmune diseases; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08331513 chr11:2906981 CDKN1C 0.55 6.16 0.35 2.71e-9 Gut microbiome composition (summer); CESC cis rs1670533 1.000 rs11735663 chr4:1051845 C/T cg27284194 chr4:1044797 NA 0.44 5.5 0.32 8.83e-8 Recombination rate (females); CESC cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg26597838 chr10:835615 NA 0.87 9.37 0.5 3.21e-18 Eosinophil percentage of granulocytes; CESC cis rs2635047 0.615 rs2684819 chr18:44710691 C/T cg24371990 chr18:44770781 NA 0.32 5.15 0.3 5.03e-7 Educational attainment; CESC cis rs926938 0.527 rs360678 chr1:115493902 T/A cg12756093 chr1:115239321 AMPD1 0.45 6.18 0.36 2.37e-9 Autism; CESC cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.63 -8.04 -0.44 3.09e-14 Tonsillectomy; CESC cis rs12220238 0.915 rs61045754 chr10:76153125 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.55 5.1 0.3 6.42e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs367943 0.712 rs9326888 chr5:112731133 A/C cg12552261 chr5:112820674 MCC 0.39 5.25 0.31 3.18e-7 Type 2 diabetes; CESC cis rs7107174 1.000 rs10793308 chr11:78086005 C/T cg02023728 chr11:77925099 USP35 0.38 5.27 0.31 2.84e-7 Testicular germ cell tumor; CESC cis rs910316 0.687 rs175059 chr14:75490667 T/C cg16144293 chr14:75469539 EIF2B2 0.4 5.26 0.31 2.91e-7 Height; CESC trans rs3942852 0.806 rs1503188 chr11:48117478 C/T cg15704280 chr7:45808275 SEPT13 -0.64 -7.53 -0.42 7.89e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs9303280 0.773 rs4795397 chr17:38023745 A/G cg19468946 chr17:37922297 IKZF3 -0.42 -5.66 -0.33 3.94e-8 Self-reported allergy; CESC cis rs698833 0.828 rs1067341 chr2:44623687 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 6.06 0.35 4.73e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg00149659 chr3:10157352 C3orf10 0.71 8.73 0.47 2.93e-16 Alzheimer's disease; CESC cis rs4450798 0.793 rs62234789 chr3:13750425 G/A cg05589046 chr3:13742034 LOC285375 0.38 5.6 0.33 5.41e-8 Bipolar disorder with mood-incongruent psychosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05550202 chr5:177481396 NA -0.58 -6.91 -0.39 3.62e-11 Gut microbiome composition (summer); CESC cis rs3741151 0.773 rs7110369 chr11:73160946 C/A cg17517138 chr11:73019481 ARHGEF17 1.0 7.41 0.41 1.74e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs561341 1.000 rs548957 chr17:30302411 G/A cg00745463 chr17:30367425 LRRC37B -0.78 -7.09 -0.4 1.2e-11 Hip circumference adjusted for BMI; CESC cis rs6502050 0.805 rs6502057 chr17:80082060 A/G cg01763666 chr17:80159506 CCDC57 0.37 5.26 0.31 2.92e-7 Life satisfaction; CESC trans rs4596713 0.507 rs10115283 chr9:71801162 T/G cg16512924 chr15:28394682 HERC2 0.48 6.11 0.35 3.47e-9 Headache; CESC trans rs629535 0.679 rs62511660 chr8:70157089 G/A cg21567404 chr3:27674614 NA -0.83 -9.14 -0.49 1.69e-17 Dupuytren's disease; CESC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg12311346 chr5:56204834 C5orf35 -0.68 -8.25 -0.45 7.46e-15 Initial pursuit acceleration; CESC cis rs12824058 0.798 rs4759652 chr12:130808771 C/T cg24838063 chr12:130822603 PIWIL1 0.62 8.3 0.45 5.43e-15 Menopause (age at onset); CESC trans rs853679 0.882 rs4713140 chr6:28097193 C/T cg06606381 chr12:133084897 FBRSL1 -0.61 -6.04 -0.35 5.1e-9 Depression; CESC cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg01579765 chr21:45077557 HSF2BP -0.56 -9.42 -0.5 2.39e-18 Mean corpuscular volume; CESC cis rs6449957 0.639 rs40419 chr5:67515602 T/C cg23036683 chr5:67512108 NA 0.47 6.51 0.37 3.71e-10 Cleft lip with or without cleft palate; CESC cis rs113835537 0.529 rs11227515 chr11:66287383 C/T cg24851651 chr11:66362959 CCS 0.42 5.22 0.31 3.64e-7 Airway imaging phenotypes; CESC cis rs12476592 0.543 rs4671510 chr2:63742880 A/G cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs1371867 0.875 rs962452 chr8:101331369 G/A cg11906718 chr8:101322791 RNF19A 0.46 5.91 0.34 1.03e-8 Atrioventricular conduction; CESC cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.67 7.81 0.43 1.36e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg24829409 chr8:58192753 C8orf71 -0.75 -9.71 -0.51 2.85e-19 Developmental language disorder (linguistic errors); CESC cis rs7084402 0.934 rs1658428 chr10:60330917 T/C cg07615347 chr10:60278583 BICC1 0.59 9.15 0.49 1.57e-17 Refractive error; CESC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg14820908 chr5:178986412 RUFY1 -0.5 -7.73 -0.43 2.26e-13 Lung cancer; CESC trans rs7937682 1.000 rs7937682 chr11:111579939 C/G cg18187862 chr3:45730750 SACM1L 0.53 6.28 0.36 1.41e-9 Primary sclerosing cholangitis; CESC cis rs1670533 0.932 rs13108207 chr4:1054218 C/T cg27284194 chr4:1044797 NA 0.45 5.8 0.34 1.93e-8 Recombination rate (females); CESC cis rs7647973 0.592 rs6774202 chr3:49687779 T/G cg13072238 chr3:49761600 GMPPB -0.44 -5.41 -0.32 1.41e-7 Menarche (age at onset); CESC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg25036284 chr2:26402008 FAM59B -0.82 -9.33 -0.5 4.47e-18 Gut microbiome composition (summer); CESC cis rs6088580 0.634 rs6059824 chr20:33014543 T/C cg24642439 chr20:33292090 TP53INP2 0.53 6.91 0.39 3.58e-11 Glomerular filtration rate (creatinine); CESC cis rs17376456 0.877 rs17083460 chr5:93462354 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.44 0.32 1.23e-7 Diabetic retinopathy; CESC cis rs7267979 0.586 rs6050445 chr20:25195394 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.69 11.45 0.58 6.22e-25 Liver enzyme levels (alkaline phosphatase); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg07418289 chr13:92004352 MIR17HG 0.42 6.39 0.37 7.54e-10 Cleft plate (environmental tobacco smoke interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17913451 chr14:58619030 C14orf37 0.47 6.4 0.37 6.83e-10 Systemic lupus erythematosus; CESC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg18230493 chr5:56204884 C5orf35 0.66 7.96 0.44 5.2e-14 Initial pursuit acceleration; CESC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg22143856 chr6:28129313 ZNF389 0.45 5.5 0.32 8.9e-8 Parkinson's disease; CESC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg11494091 chr17:61959527 GH2 0.72 12.16 0.6 2.58e-27 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00040446 chr1:40367965 MYCL1 0.59 7.12 0.4 1.01e-11 Gut microbiome composition (summer); CESC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg05332525 chr7:65337924 VKORC1L1 0.49 6.11 0.35 3.57e-9 Aortic root size; CESC cis rs1506636 0.962 rs10243279 chr7:123441262 T/A cg03229431 chr7:123269106 ASB15 0.48 5.99 0.35 6.71e-9 Plateletcrit;Platelet count; CESC cis rs2710642 0.611 rs2204655 chr2:62883786 C/T cg17519650 chr2:63277830 OTX1 0.44 5.26 0.31 2.91e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs7940866 0.803 rs1865296 chr11:130882944 C/T cg12179176 chr11:130786555 SNX19 -0.66 -10.63 -0.55 3.21e-22 Schizophrenia; CESC cis rs12476592 0.602 rs6546019 chr2:63817440 A/G cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC cis rs7605827 0.930 rs6733519 chr2:15525567 T/C cg19274914 chr2:15703543 NA 0.35 6.11 0.35 3.61e-9 Educational attainment (years of education); CESC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg07701084 chr6:150067640 NUP43 0.43 6.0 0.35 6.52e-9 Lung cancer; CESC cis rs17407555 0.606 rs73229818 chr4:10019884 C/T cg00071950 chr4:10020882 SLC2A9 -0.6 -6.16 -0.35 2.64e-9 Schizophrenia (age at onset); CESC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg12963246 chr6:28129442 ZNF389 0.58 7.56 0.42 6.4e-13 Depression; CESC cis rs4141404 0.640 rs9606854 chr22:31930567 C/T cg00478049 chr22:31556069 RNF185 -0.51 -5.53 -0.32 7.72e-8 Paclitaxel-induced neuropathy; CESC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg07507251 chr3:52567010 NT5DC2 -0.43 -7.37 -0.41 2.2e-12 Bipolar disorder; CESC cis rs9583531 0.891 rs61969072 chr13:111380701 T/G cg24331049 chr13:111365604 ING1 -0.75 -7.82 -0.43 1.26e-13 Coronary artery disease; CESC cis rs9796 0.653 rs28516683 chr15:41446645 A/G cg18705301 chr15:41695430 NDUFAF1 -0.46 -6.87 -0.39 4.48e-11 Menopause (age at onset); CESC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg04944784 chr2:26401820 FAM59B -0.96 -10.55 -0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 8.36 0.46 3.59e-15 Schizophrenia; CESC cis rs909002 0.800 rs7549590 chr1:32109849 G/A cg13919466 chr1:32135498 COL16A1 -0.47 -8.43 -0.46 2.3e-15 Intelligence (multi-trait analysis); CESC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg14926445 chr8:58193284 C8orf71 -0.52 -5.53 -0.32 7.54e-8 Developmental language disorder (linguistic errors); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg10651637 chr15:45315642 SORD 0.44 6.33 0.36 1.03e-9 Bronchopulmonary dysplasia; CESC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg15145296 chr3:125709740 NA -0.54 -5.96 -0.34 8.2e-9 Blood pressure (smoking interaction); CESC trans rs11722228 1.000 rs4697695 chr4:9915850 C/T cg26043149 chr18:55253948 FECH 0.48 6.47 0.37 4.6e-10 Gout;Urate levels;Serum uric acid levels; CESC cis rs7216064 1.000 rs56148300 chr17:65892752 T/C cg12091567 chr17:66097778 LOC651250 -0.75 -8.7 -0.47 3.59e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs738322 0.901 rs132941 chr22:38545942 T/C cg25457927 chr22:38595422 NA -0.3 -5.48 -0.32 9.77e-8 Cutaneous nevi; CESC cis rs2051211 1.000 rs2051211 chr3:38559749 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.62 -7.35 -0.41 2.45e-12 QRS duration; CESC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg13628971 chr7:2884303 GNA12 0.62 7.84 0.43 1.11e-13 Height; CESC cis rs6912958 0.781 rs985764 chr6:88215206 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.65 -0.38 1.66e-10 Monocyte percentage of white cells; CESC cis rs10883723 0.773 rs11191313 chr10:104278618 C/T cg22532475 chr10:104410764 TRIM8 -0.41 -6.32 -0.36 1.08e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs703842 0.616 rs7489290 chr12:58228588 C/G cg02175503 chr12:58329896 NA 0.48 5.85 0.34 1.44e-8 Multiple sclerosis; CESC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg18350739 chr11:68623251 NA -0.44 -6.81 -0.39 6.64e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg26314531 chr2:26401878 FAM59B 0.81 8.1 0.45 2.06e-14 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16326998 chr7:5553266 FBXL18 -0.5 -6.59 -0.38 2.36e-10 Fibrinogen levels; CESC cis rs9902453 0.765 rs34585141 chr17:28336432 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.69 -0.47 3.76e-16 Coffee consumption (cups per day); CESC cis rs854765 0.551 rs56886154 chr17:17831473 C/A cg09796270 chr17:17721594 SREBF1 0.46 6.39 0.37 7.35e-10 Total body bone mineral density; CESC cis rs7927592 0.913 rs11228268 chr11:68287447 A/T cg20283391 chr11:68216788 NA -0.63 -7.61 -0.42 4.78e-13 Total body bone mineral density; CESC cis rs77741769 0.571 rs11065282 chr12:121264415 G/T cg02419362 chr12:121203948 SPPL3 0.33 5.43 0.32 1.31e-7 Mean corpuscular volume; CESC cis rs7044106 0.791 rs10985004 chr9:123484937 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.75 11.22 0.57 3.67e-24 Hip circumference adjusted for BMI; CESC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg05564831 chr3:52568323 NT5DC2 0.48 7.7 0.43 2.71e-13 Electroencephalogram traits; CESC cis rs10883723 0.773 rs7917402 chr10:104246690 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.56 0.42 6.43e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg04267008 chr7:1944627 MAD1L1 -0.57 -6.68 -0.38 1.44e-10 Bipolar disorder and schizophrenia; CESC cis rs7914558 1.000 rs10786733 chr10:104794947 G/A cg15744005 chr10:104629667 AS3MT -0.34 -5.53 -0.32 7.79e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs698833 0.828 rs6705951 chr2:44534012 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.78 0.33 2.13e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg24829409 chr8:58192753 C8orf71 -0.78 -10.18 -0.53 9.38e-21 Developmental language disorder (linguistic errors); CESC cis rs16937 0.640 rs6664706 chr1:205182563 T/C cg21643547 chr1:205240462 TMCC2 -0.33 -5.4 -0.31 1.48e-7 Schizophrenia; CESC cis rs9815354 0.812 rs56290987 chr3:42004882 T/C cg03022575 chr3:42003672 ULK4 0.65 5.73 0.33 2.75e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs9902453 0.740 rs2729446 chr17:28102499 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs243505 0.559 rs1558420 chr7:148480114 G/T cg09806900 chr7:148480153 CUL1 0.44 5.27 0.31 2.83e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg07167872 chr1:205819463 PM20D1 0.48 7.28 0.41 3.92e-12 Menarche (age at onset); CESC cis rs9911578 0.934 rs8081967 chr17:57072701 T/C cg12560992 chr17:57184187 TRIM37 1.0 17.01 0.72 2.3e-44 Intelligence (multi-trait analysis); CESC cis rs67311347 1.000 rs2305521 chr3:40429183 A/G cg09455208 chr3:40491958 NA 0.45 7.5 0.42 9.87e-13 Renal cell carcinoma; CESC cis rs6831352 1.000 rs6837685 chr4:100049145 G/A cg13256891 chr4:100009986 ADH5 0.72 8.45 0.46 1.94e-15 Alcohol dependence; CESC cis rs7103648 0.735 rs3824869 chr11:47378245 T/C cg03711944 chr11:47377212 SPI1 0.42 6.47 0.37 4.67e-10 Diastolic blood pressure;Systolic blood pressure; CESC cis rs10927875 0.632 rs904911 chr1:16126932 C/T cg18973939 chr1:16164122 FLJ37453 0.37 5.52 0.32 8.2e-8 Dilated cardiomyopathy; CESC cis rs3820928 0.874 rs6728239 chr2:227856552 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -5.07 -0.3 7.64e-7 Pulmonary function; CESC cis rs6785206 0.803 rs6774512 chr3:128415868 C/T cg16766828 chr3:128327626 NA -0.53 -5.08 -0.3 7.02e-7 Lymphocyte percentage of white cells; CESC cis rs916888 0.773 rs169201 chr17:44790203 A/G cg17911788 chr17:44343683 NA -0.63 -8.1 -0.45 2.09e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs875971 0.638 rs10278816 chr7:66036987 T/C cg26939375 chr7:64535504 NA -0.64 -8.62 -0.47 6.05e-16 Aortic root size; CESC cis rs11155671 0.530 rs2342769 chr6:150216507 T/C cg11878867 chr6:150167359 LRP11 -0.35 -5.06 -0.3 8.01e-7 Testicular germ cell tumor; CESC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg11843238 chr5:131593191 PDLIM4 0.35 5.21 0.3 3.8e-7 Breast cancer; CESC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg10691866 chr7:65817282 TPST1 -0.35 -5.62 -0.33 4.9e-8 Aortic root size; CESC cis rs30380 0.922 rs246453 chr5:96123336 T/C cg16492584 chr5:96139282 ERAP1 -0.35 -5.35 -0.31 1.95e-7 Cerebrospinal fluid biomarker levels; CESC trans rs7615952 0.576 rs66671308 chr3:125793526 T/G cg07211511 chr3:129823064 LOC729375 -0.57 -6.39 -0.37 7.57e-10 Blood pressure (smoking interaction); CESC cis rs2231884 0.697 rs11227332 chr11:65623739 A/G cg04055107 chr11:65626734 MUS81;CFL1 1.0 8.94 0.48 6.64e-17 Inflammatory bowel disease; CESC cis rs4955124 0.643 rs17028714 chr3:32041229 T/C cg05935571 chr3:32023257 ZNF860;OSBPL10 0.82 6.4 0.37 7.07e-10 Schizophrenia; CESC cis rs7605378 0.567 rs717915 chr2:200714766 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.47 5.23 0.31 3.53e-7 Osteoporosis; CESC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg11890956 chr21:40555474 PSMG1 1.15 22.29 0.81 1.04e-62 Cognitive function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10258395 chr2:240026647 HDAC4 0.47 6.16 0.35 2.72e-9 Fibrinogen levels; CESC cis rs7107174 0.581 rs11237485 chr11:78126011 G/A cg02023728 chr11:77925099 USP35 0.44 5.64 0.33 4.28e-8 Testicular germ cell tumor; CESC cis rs13095912 1.000 rs6784948 chr3:185342787 C/T cg11274856 chr3:185301563 NA 0.35 5.55 0.32 6.89e-8 Systolic blood pressure; CESC cis rs57502260 0.679 rs72936524 chr11:68275898 G/A cg20283391 chr11:68216788 NA -0.68 -5.61 -0.33 4.99e-8 Total body bone mineral density (age 45-60); CESC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg04414720 chr1:150670196 GOLPH3L 0.45 5.9 0.34 1.12e-8 Melanoma; CESC cis rs11098499 0.644 rs7693919 chr4:120540571 G/A cg09307838 chr4:120376055 NA 0.74 9.84 0.52 1.16e-19 Corneal astigmatism; CESC cis rs8049040 0.586 rs16972663 chr16:71460564 C/T cg08717414 chr16:71523259 ZNF19 -0.61 -6.65 -0.38 1.65e-10 Blood protein levels; CESC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg07870213 chr5:140052090 DND1 0.63 7.01 0.4 2e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6594499 0.564 rs12518884 chr5:110452223 A/G cg04022379 chr5:110408740 TSLP 0.43 7.38 0.41 2.08e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs11785400 0.793 rs4587307 chr8:143738529 G/A cg10596483 chr8:143751796 JRK 0.43 5.41 0.32 1.37e-7 Schizophrenia; CESC cis rs7589342 0.899 rs879900 chr2:106494347 A/G cg14210321 chr2:106509881 NCK2 -0.47 -5.48 -0.32 9.71e-8 Addiction; CESC cis rs10504229 1.000 rs58608483 chr8:58195269 T/G cg05313129 chr8:58192883 C8orf71 -0.48 -5.86 -0.34 1.35e-8 Developmental language disorder (linguistic errors); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22015966 chr11:47198573 ARFGAP2 0.46 6.01 0.35 6.22e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg04287289 chr16:89883240 FANCA 0.9 16.31 0.71 6.93e-42 Vitiligo; CESC cis rs2228479 1.000 rs62052186 chr16:89969567 A/T cg00800038 chr16:89945340 TCF25 -0.91 -7.41 -0.41 1.71e-12 Skin colour saturation; CESC cis rs2735413 0.802 rs6564504 chr16:78095419 G/T cg04733911 chr16:78082701 NA 0.46 7.28 0.41 3.75e-12 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg24818145 chr4:99064322 C4orf37 0.4 5.14 0.3 5.46e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs7221875 chr17:37543328 G/A cg15445000 chr17:37608096 MED1 -0.38 -6.28 -0.36 1.39e-9 Glomerular filtration rate (creatinine); CESC cis rs1949733 0.635 rs4358384 chr4:8536913 C/T cg11789530 chr4:8429930 ACOX3 -0.64 -8.03 -0.44 3.14e-14 Response to antineoplastic agents; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23388371 chr19:36359516 APLP1 0.55 6.23 0.36 1.8e-9 Gut microbiome composition (summer); CESC cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg00033643 chr7:134001901 SLC35B4 0.41 5.27 0.31 2.8e-7 Mean platelet volume; CESC cis rs2243480 0.901 rs2900904 chr7:65204264 C/G cg18252515 chr7:66147081 NA -1.26 -11.91 -0.59 1.81e-26 Diabetic kidney disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11179286 chr13:115047994 UPF3A -0.43 -6.24 -0.36 1.72e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9790314 1.000 rs7647327 chr3:161016421 T/C cg03342759 chr3:160939853 NMD3 -0.44 -5.77 -0.33 2.15e-8 Morning vs. evening chronotype; CESC cis rs66731853 0.769 rs530104 chr1:20895721 A/G cg04087271 chr1:20915334 CDA -0.58 -7.01 -0.4 1.93e-11 Mean corpuscular volume; CESC cis rs7623687 0.892 rs73088122 chr3:49432404 C/T cg07274523 chr3:49395745 GPX1 0.64 5.63 0.33 4.66e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CESC cis rs3820928 0.904 rs4439949 chr2:227764954 T/G cg11843606 chr2:227700838 RHBDD1 -0.45 -5.93 -0.34 9.45e-9 Pulmonary function; CESC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 21.95 0.8 1.49e-61 Prudent dietary pattern; CESC cis rs637571 0.544 rs55704213 chr11:65730002 C/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.48 6.28 0.36 1.39e-9 Eosinophil percentage of white cells; CESC cis rs8072100 0.840 rs9900360 chr17:45491979 C/T cg25173405 chr17:45401733 C17orf57 -0.42 -5.53 -0.32 7.75e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs765787 0.530 rs1706835 chr15:45517884 G/A cg24006582 chr15:45444508 DUOX1 -0.57 -6.88 -0.39 4.22e-11 Uric acid levels; CESC cis rs7246657 0.525 rs1667351 chr19:37478027 A/T cg23950597 chr19:37808831 NA -0.43 -5.05 -0.3 8.1e-7 Coronary artery calcification; CESC cis rs17293817 0.617 rs55894130 chr10:1413338 G/A cg04271617 chr10:1416546 ADARB2 0.35 5.36 0.31 1.83e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2294693 0.786 rs12055704 chr6:40988504 C/T cg14418226 chr6:40996092 UNC5CL 0.54 6.14 0.35 3.06e-9 Gastric cancer;Non-cardia gastric cancer; CESC cis rs12142240 0.698 rs57267378 chr1:46816644 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs17095355 1.000 rs12569906 chr10:111706856 A/T cg00817464 chr10:111662876 XPNPEP1 -0.47 -5.48 -0.32 9.82e-8 Biliary atresia; CESC cis rs9300255 0.537 rs1790101 chr12:123704844 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.89 0.48 9.66e-17 Neutrophil percentage of white cells; CESC cis rs36207871 1 rs36207871 chr12:56684496 TAGGAA/T cg26714650 chr12:56694279 CS 1.29 16.3 0.71 7.7e-42 Inflammatory skin disease; CESC cis rs9611565 0.840 rs4822025 chr22:41776646 C/G cg06481639 chr22:41940642 POLR3H -0.61 -6.46 -0.37 5.12e-10 Vitiligo; CESC cis rs16866061 0.515 rs13020268 chr2:225437923 C/T cg12698349 chr2:225449008 CUL3 0.82 14.85 0.67 1.06e-36 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs6460942 0.597 rs4721105 chr7:12534881 C/T cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC trans rs61931739 0.929 rs1825358 chr12:34011895 C/T cg26384229 chr12:38710491 ALG10B -0.45 -6.19 -0.36 2.29e-9 Morning vs. evening chronotype; CESC cis rs9549367 0.724 rs7985335 chr13:113869244 G/T cg00898013 chr13:113819073 PROZ 0.49 7.38 0.41 2.1e-12 Platelet distribution width; CESC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg20203395 chr5:56204925 C5orf35 0.4 5.15 0.3 5.15e-7 Initial pursuit acceleration; CESC cis rs6728642 0.831 rs10496325 chr2:97683329 C/T cg26665480 chr2:98280029 ACTR1B 0.67 7.33 0.41 2.75e-12 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs7605827 0.930 rs13006997 chr2:15700872 T/C cg19274914 chr2:15703543 NA 0.3 5.34 0.31 2.03e-7 Educational attainment (years of education); CESC cis rs3820068 0.603 rs6429767 chr1:15963334 G/A cg13390004 chr1:15929781 NA 0.37 5.9 0.34 1.11e-8 Systolic blood pressure; CESC cis rs60733400 0.782 rs4648564 chr1:2562169 C/T cg18854424 chr1:2615690 NA -0.31 -6.19 -0.36 2.29e-9 Multiple sclerosis; CESC cis rs10995240 1 rs10995240 chr10:64388631 G/C cg03961010 chr10:64397487 ZNF365 -0.39 -6.22 -0.36 1.94e-9 Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes;Eosinophil percentage of white cells;Eosinophil counts; CESC cis rs155076 0.938 rs9509630 chr13:21844314 G/A cg11317459 chr13:21872234 NA -1.01 -11.12 -0.56 7.88e-24 White matter hyperintensity burden; CESC cis rs7044106 0.734 rs12553070 chr9:123485266 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.73 10.79 0.55 9.7e-23 Hip circumference adjusted for BMI; CESC cis rs826838 0.967 rs11183622 chr12:38792849 T/C cg13010199 chr12:38710504 ALG10B 0.6 8.53 0.46 1.1e-15 Heart rate; CESC cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg17366294 chr4:99064904 C4orf37 0.6 8.59 0.47 7.62e-16 Colonoscopy-negative controls vs population controls; CESC cis rs12190007 0.547 rs3006217 chr6:169862878 A/G cg15038512 chr6:170123185 PHF10 -0.54 -7.97 -0.44 4.64e-14 Obesity-related traits; CESC cis rs7216064 0.861 rs73352810 chr17:65875184 G/A cg12091567 chr17:66097778 LOC651250 -0.81 -9.2 -0.49 1.14e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1595825 0.891 rs76637837 chr2:198529496 G/A cg10820045 chr2:198174542 NA 0.41 5.21 0.3 3.79e-7 Ulcerative colitis; CESC trans rs11088226 0.681 rs74779447 chr21:33929013 G/A cg09050820 chr6:167586206 TCP10L2 0.84 8.07 0.44 2.46e-14 Gastritis; CESC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg07701084 chr6:150067640 NUP43 0.45 6.39 0.37 7.37e-10 Lung cancer; CESC cis rs4268898 0.931 rs34504814 chr2:24503766 C/T cg06627628 chr2:24431161 ITSN2 -0.71 -8.66 -0.47 4.59e-16 Asthma; CESC cis rs710216 0.879 rs710218 chr1:43427218 A/T cg07803811 chr1:43423981 SLC2A1 0.46 5.26 0.31 2.99e-7 Red cell distribution width; CESC cis rs9303401 0.527 rs12939313 chr17:56755616 A/T cg10487724 chr17:56770010 TEX14;RAD51C 1.03 11.15 0.57 6.17e-24 Cognitive test performance; CESC cis rs66530629 0.874 rs10903106 chr1:25148686 G/A cg22509179 chr1:25234806 RUNX3 -0.42 -5.38 -0.31 1.63e-7 Plateletcrit; CESC cis rs56104184 0.775 rs73061692 chr19:49399676 T/C cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs2295359 0.892 rs72676067 chr1:67658803 G/A cg03340356 chr1:67600835 NA 0.32 5.27 0.31 2.76e-7 Psoriasis; CESC cis rs2342371 0.545 rs4393941 chr3:196206743 A/G cg15048948 chr3:196158458 UBXN7 -0.4 -5.66 -0.33 3.92e-8 Fat distribution (HIV); CESC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.03 -0.49 3.55e-17 Developmental language disorder (linguistic errors); CESC cis rs9399135 0.967 rs9389256 chr6:135331254 A/C cg22676075 chr6:135203613 NA 0.5 7.04 0.4 1.61e-11 Red blood cell count; CESC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.57 -0.32 6.38e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6831352 0.918 rs13133647 chr4:100058727 C/T cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg00149659 chr3:10157352 C3orf10 0.71 8.69 0.47 3.84e-16 Alzheimer's disease; CESC cis rs947211 0.898 rs1772156 chr1:205752894 T/C cg17178900 chr1:205818956 PM20D1 0.4 5.22 0.31 3.69e-7 Parkinson's disease; CESC cis rs16867321 0.666 rs7556967 chr2:181586333 C/T cg23363182 chr2:181467187 NA -0.43 -5.7 -0.33 3.2e-8 Obesity; CESC cis rs61931739 0.500 rs10772163 chr12:34532950 T/C cg06521331 chr12:34319734 NA -0.37 -5.15 -0.3 5.19e-7 Morning vs. evening chronotype; CESC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs1451375 0.617 rs17733244 chr7:50575495 T/C cg14593290 chr7:50529359 DDC 0.52 6.05 0.35 5.03e-9 Malaria; CESC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg02951883 chr7:2050386 MAD1L1 -0.4 -5.31 -0.31 2.32e-7 Bipolar disorder and schizophrenia; CESC cis rs6728642 1.000 rs73959416 chr2:97604518 A/T cg26665480 chr2:98280029 ACTR1B -0.7 -6.92 -0.39 3.47e-11 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs8020095 0.571 rs68178754 chr14:67383094 T/C cg19548862 chr14:67692701 FAM71D -0.49 -5.94 -0.34 8.86e-9 Depression (quantitative trait); CESC cis rs9457247 0.967 rs424185 chr6:167410907 C/T cg07741184 chr6:167504864 NA 0.3 5.52 0.32 8.06e-8 Crohn's disease; CESC cis rs3806843 0.676 rs778594 chr5:140027304 T/C cg26395211 chr5:140044315 WDR55 0.52 6.54 0.37 3.13e-10 Depressive symptoms (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01719780 chr1:157126054 NA 0.56 6.6 0.38 2.18e-10 Gut microbiome composition (summer); CESC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg05776053 chr2:74358815 NA 0.44 5.27 0.31 2.78e-7 Gestational age at birth (maternal effect); CESC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs1814175 0.817 rs1794164 chr11:49899610 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -20.27 -0.78 8.31e-56 Height; CESC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg10691866 chr7:65817282 TPST1 -0.34 -5.51 -0.32 8.37e-8 Aortic root size; CESC cis rs3617 0.559 rs11915546 chr3:52866845 A/C cg07507251 chr3:52567010 NT5DC2 -0.32 -5.43 -0.32 1.27e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg18099408 chr3:52552593 STAB1 -0.31 -5.14 -0.3 5.23e-7 Electroencephalogram traits; CESC cis rs2204008 0.685 rs4556621 chr12:38187236 C/A cg13010199 chr12:38710504 ALG10B 0.53 6.64 0.38 1.79e-10 Bladder cancer; CESC cis rs3105593 1.000 rs934625 chr15:50968756 T/C cg08437265 chr15:50716283 USP8 0.45 5.93 0.34 9.66e-9 QT interval; CESC cis rs9837602 1.000 rs9837602 chr3:99824685 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 6.84 0.39 5.38e-11 Breast cancer; CESC trans rs1728785 1.000 rs1645976 chr16:68563509 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs4132509 0.744 rs12047209 chr1:243954407 A/C cg21452805 chr1:244014465 NA 0.66 7.24 0.41 4.81e-12 RR interval (heart rate); CESC cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg15017067 chr4:17643749 FAM184B 0.37 5.2 0.3 3.95e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1355223 0.902 rs836467 chr11:34737432 G/A cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.2 -0.36 2.14e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs3820928 0.874 rs2229812 chr2:227896886 C/T cg11843606 chr2:227700838 RHBDD1 -0.49 -6.4 -0.37 6.87e-10 Pulmonary function; CESC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg24829409 chr8:58192753 C8orf71 -0.7 -7.79 -0.43 1.49e-13 Developmental language disorder (linguistic errors); CESC cis rs9611565 0.879 rs5758311 chr22:41759375 G/T cg06481639 chr22:41940642 POLR3H -0.44 -5.14 -0.3 5.26e-7 Vitiligo; CESC cis rs559928 0.597 rs947939 chr11:63885287 C/T cg18225595 chr11:63971243 STIP1 0.64 5.47 0.32 1.05e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs116095464 0.510 rs73016876 chr5:244475 T/C cg22496380 chr5:211416 CCDC127 -0.79 -9.12 -0.49 1.95e-17 Breast cancer; CESC cis rs425277 1.000 rs381664 chr1:2088104 A/G cg16545954 chr1:2118288 C1orf86 0.33 5.63 0.33 4.65e-8 Height; CESC cis rs7481584 0.962 rs2237905 chr11:2976584 T/C cg25174290 chr11:3078921 CARS -0.49 -5.88 -0.34 1.21e-8 Calcium levels; CESC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg11644478 chr21:40555479 PSMG1 1.02 16.18 0.7 1.98e-41 Cognitive function; CESC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.63 0.33 4.71e-8 Depression; CESC cis rs2439831 0.702 rs7171750 chr15:44025858 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.7 6.6 0.38 2.25e-10 Lung cancer in ever smokers; CESC cis rs1023500 1.000 rs3752591 chr22:42339516 A/G cg03806693 chr22:41940476 POLR3H -0.52 -5.2 -0.3 4e-7 Schizophrenia; CESC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg02841227 chr6:26021843 HIST1H4A 0.44 5.35 0.31 1.91e-7 Intelligence (multi-trait analysis); CESC cis rs9527 0.590 rs7917650 chr10:104937100 G/C cg04362960 chr10:104952993 NT5C2 0.43 5.33 0.31 2.05e-7 Arsenic metabolism; CESC cis rs938554 0.779 rs4639073 chr4:9973781 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -5.11 -0.3 6.17e-7 Blood metabolite levels; CESC cis rs6964587 1.000 rs34548928 chr7:91668365 G/A cg17063962 chr7:91808500 NA 0.6 8.31 0.45 4.96e-15 Breast cancer; CESC cis rs3096299 0.900 rs2911258 chr16:89480760 A/G cg00750074 chr16:89608354 SPG7 -0.36 -5.1 -0.3 6.59e-7 Multiple myeloma (IgH translocation); CESC cis rs6732160 0.588 rs13403748 chr2:73371475 T/C cg01422370 chr2:73384389 NA 0.56 8.95 0.48 6.23e-17 Intelligence (multi-trait analysis); CESC cis rs962856 1.000 rs1032157 chr2:67601816 C/T cg09028215 chr2:67624308 ETAA1 -0.41 -5.4 -0.31 1.48e-7 Pancreatic cancer; CESC cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg03213289 chr20:61660250 NA 0.39 6.16 0.35 2.7e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs4237845 0.967 rs4553410 chr12:58301211 G/A cg00677455 chr12:58241039 CTDSP2 0.5 6.29 0.36 1.32e-9 Intelligence (multi-trait analysis); CESC cis rs807669 0.525 rs9605955 chr22:19181557 C/T cg02655711 chr22:19163373 SLC25A1 0.42 6.16 0.35 2.66e-9 Metabolite levels; CESC cis rs2017305 0.834 rs79520726 chr10:70781956 T/C cg01024728 chr10:70782572 NA 0.56 5.35 0.31 1.89e-7 Depression (quantitative trait); CESC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg18876405 chr7:65276391 NA 0.5 6.48 0.37 4.33e-10 Aortic root size; CESC cis rs7395581 0.918 rs10838693 chr11:47350553 G/C cg25783544 chr11:47291846 MADD 0.58 7.42 0.41 1.55e-12 HDL cholesterol; CESC cis rs9612 1.000 rs346545 chr19:44256386 T/C cg08581076 chr19:44259116 C19orf61 0.52 6.19 0.36 2.33e-9 Exhaled nitric oxide output; CESC cis rs787274 1.000 rs1965335 chr9:115504483 C/T cg13803584 chr9:115635662 SNX30 0.57 5.16 0.3 4.84e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4780401 0.642 rs7194145 chr16:11764615 T/G cg01061890 chr16:11836724 TXNDC11 -0.39 -5.06 -0.3 7.71e-7 Rheumatoid arthritis; CESC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg21724239 chr8:58056113 NA 0.59 5.64 0.33 4.27e-8 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.35 0.6 5.51e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2249694 0.922 rs4306261 chr10:135410989 A/G cg19469447 chr10:135341870 CYP2E1 0.36 5.09 0.3 6.96e-7 Obesity-related traits; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24657977 chr1:206859686 MAPKAPK2 -0.5 -6.01 -0.35 6.15e-9 Ulcerative colitis; CESC cis rs17376456 0.877 rs10055741 chr5:93297187 C/T cg21475434 chr5:93447410 FAM172A 0.76 6.9 0.39 3.89e-11 Diabetic retinopathy; CESC cis rs7107174 1.000 rs9651769 chr11:77996166 T/C cg02023728 chr11:77925099 USP35 0.48 6.68 0.38 1.41e-10 Testicular germ cell tumor; CESC cis rs72945132 0.882 rs12278741 chr11:70135742 A/G cg00319359 chr11:70116639 PPFIA1 0.78 7.67 0.43 3.32e-13 Coronary artery disease; CESC cis rs6693567 0.565 rs834242 chr1:150379858 G/A cg09579323 chr1:150459698 TARS2 0.45 5.85 0.34 1.41e-8 Migraine; CESC cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg26874164 chr19:58962979 ZNF324B 0.54 7.54 0.42 7.72e-13 Uric acid clearance; CESC cis rs2228479 0.702 rs17233441 chr16:89817998 C/G cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.57 0.47 8.74e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg12463550 chr7:65579703 CRCP 0.55 7.03 0.4 1.76e-11 Aortic root size; CESC cis rs67311347 0.869 rs9832311 chr3:40381322 A/T cg09455208 chr3:40491958 NA 0.47 8.1 0.45 2.08e-14 Renal cell carcinoma; CESC cis rs2011503 1.000 rs2011503 chr19:19443986 C/T cg11584989 chr19:19387371 SF4 0.63 7.59 0.42 5.5e-13 Bipolar disorder; CESC cis rs250677 0.687 rs36044 chr5:148441128 T/C cg18129178 chr5:148520854 ABLIM3 -0.52 -5.94 -0.34 8.76e-9 Breast cancer; CESC cis rs17666538 0.585 rs1669615 chr8:616665 T/C cg23958373 chr8:599963 NA 0.83 6.04 0.35 5.2e-9 IgG glycosylation; CESC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg00166722 chr3:10149974 C3orf24 0.48 5.95 0.34 8.39e-9 Alzheimer's disease; CESC cis rs9291683 0.610 rs993172 chr4:10324361 G/T cg00071950 chr4:10020882 SLC2A9 0.55 8.06 0.44 2.56e-14 Bone mineral density; CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg06877462 chr1:205807181 PM20D1 -0.34 -5.33 -0.31 2.15e-7 Monocyte percentage of white cells; CESC cis rs10845606 1.000 rs10845609 chr12:12838920 T/A cg04607235 chr12:12878440 APOLD1 -0.74 -8.24 -0.45 8.24e-15 Systemic lupus erythematosus; CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg05564831 chr3:52568323 NT5DC2 0.53 9.03 0.49 3.63e-17 Electroencephalogram traits; CESC cis rs2485892 0.581 rs2484032 chr1:210317225 G/A cg22029157 chr1:209979665 IRF6 0.5 5.83 0.34 1.62e-8 Manic episodes in bipolar disorder; CESC cis rs6088580 0.634 rs6142153 chr20:32968747 C/G cg06115741 chr20:33292138 TP53INP2 -0.47 -6.02 -0.35 5.66e-9 Glomerular filtration rate (creatinine); CESC cis rs412050 0.744 rs238781 chr22:22341871 C/T cg17089214 chr22:22089827 YPEL1 0.56 5.04 0.3 8.7e-7 Attention deficit hyperactivity disorder; CESC cis rs8141529 0.636 rs5762813 chr22:29203314 C/T cg02153584 chr22:29168773 CCDC117 0.48 5.26 0.31 3.04e-7 Lymphocyte counts; CESC cis rs9788333 0.707 rs12584557 chr13:21886171 C/A cg06138931 chr13:21896616 NA 0.56 7.91 0.44 7.18e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs4319547 0.774 rs7295105 chr12:123124225 G/A cg05707623 chr12:122985044 ZCCHC8 -0.51 -5.97 -0.34 7.79e-9 Body mass index; CESC cis rs62064224 0.702 rs735555 chr17:30817450 A/G cg09324608 chr17:30823087 MYO1D -0.41 -6.32 -0.36 1.1e-9 Schizophrenia; CESC cis rs5769765 0.908 rs4824109 chr22:50271460 T/C cg02269571 chr22:50332266 NA 0.47 6.34 0.36 9.73e-10 Schizophrenia; CESC cis rs820218 0.926 rs8074319 chr17:73652060 C/A cg01592526 chr17:73663357 RECQL5;SAP30BP 0.4 5.26 0.31 2.95e-7 Rotator cuff tears; CESC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg00149659 chr3:10157352 C3orf10 0.57 6.09 0.35 3.98e-9 Alzheimer's disease; CESC cis rs6460942 1.000 rs2053381 chr7:12400710 C/A cg20607287 chr7:12443886 VWDE -0.67 -7.73 -0.43 2.26e-13 Coronary artery disease; CESC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg12373951 chr3:133503437 NA 0.38 5.41 0.32 1.38e-7 Iron status biomarkers; CESC trans rs12310956 0.532 rs11052935 chr12:33970946 C/T cg26384229 chr12:38710491 ALG10B 0.51 6.98 0.39 2.42e-11 Morning vs. evening chronotype; CESC cis rs6580649 0.941 rs58046797 chr12:48487619 T/C cg05342945 chr12:48394962 COL2A1 0.5 5.74 0.33 2.59e-8 Lung cancer; CESC cis rs7223966 1.000 rs7223966 chr17:61893398 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.71 0.38 1.15e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4253772 0.575 rs9615979 chr22:46789021 G/T cg00784671 chr22:46762841 CELSR1 -0.61 -5.46 -0.32 1.11e-7 LDL cholesterol;Cholesterol, total; CESC cis rs8078723 0.763 rs4433838 chr17:38143532 C/T cg17467752 chr17:38218738 THRA -0.55 -8.15 -0.45 1.45e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg25019033 chr10:957182 NA -0.57 -6.08 -0.35 4.24e-9 Eosinophil percentage of granulocytes; CESC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg26314531 chr2:26401878 FAM59B -0.85 -9.51 -0.5 1.24e-18 Gut microbiome composition (summer); CESC cis rs1878931 0.531 rs9635548 chr16:3417156 G/A cg05754148 chr16:3507555 NAT15 -0.39 -5.19 -0.3 4.24e-7 Body mass index (adult); CESC cis rs2573652 0.963 rs2573649 chr15:100514040 C/G cg09918751 chr15:100517450 ADAMTS17 -0.38 -7.36 -0.41 2.33e-12 Height; CESC cis rs7923609 1.000 rs7910927 chr10:65138910 T/G cg01631684 chr10:65280961 REEP3 -0.42 -5.17 -0.3 4.72e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg08109568 chr15:31115862 NA -0.71 -9.44 -0.5 2.02e-18 Huntington's disease progression; CESC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg16049864 chr8:95962084 TP53INP1 -0.66 -11.67 -0.58 1.13e-25 Type 2 diabetes; CESC cis rs16910800 0.731 rs59845980 chr11:23191511 T/G cg20040320 chr11:23191996 NA -0.67 -6.66 -0.38 1.53e-10 Cancer; CESC cis rs763014 0.931 rs11648728 chr16:635525 C/T cg00802000 chr16:706648 WDR90 -0.41 -6.19 -0.36 2.26e-9 Height; CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg01516881 chr6:292596 DUSP22 0.83 11.25 0.57 3e-24 Menopause (age at onset); CESC cis rs6430585 0.697 rs7607174 chr2:136513670 T/A cg07169764 chr2:136633963 MCM6 1.27 16.82 0.72 1.04e-43 Corneal structure; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07956857 chr9:106761676 NA -0.44 -6.4 -0.37 7.08e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg18876405 chr7:65276391 NA 0.47 5.28 0.31 2.73e-7 Aortic root size; CESC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg11764359 chr7:65958608 NA -0.78 -11.07 -0.56 1.19e-23 Aortic root size; CESC cis rs7246657 0.943 rs10420754 chr19:37959372 C/G cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.69e-9 Coronary artery calcification; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14181387 chr1:36022775 NCDN;KIAA0319L 0.57 6.05 0.35 4.8e-9 Gut microbiome composition (summer); CESC cis rs1008375 0.932 rs11941874 chr4:17666416 C/T cg02297831 chr4:17616191 MED28 -0.49 -5.69 -0.33 3.28e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs79911532 0.515 rs10226745 chr7:75843603 C/T cg06959773 chr7:76033795 SRCRB4D;ZP3 0.56 5.21 0.3 3.83e-7 Mononucleosis; CESC cis rs7089973 0.584 rs758585 chr10:116582560 C/A cg03647239 chr10:116582469 FAM160B1 0.44 5.71 0.33 3.03e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs921968 0.565 rs7586384 chr2:219582897 T/C cg02176678 chr2:219576539 TTLL4 -0.43 -7.37 -0.41 2.24e-12 Mean corpuscular hemoglobin concentration; CESC trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg15704280 chr7:45808275 SEPT13 0.84 13.52 0.64 4.91e-32 Coronary artery disease; CESC cis rs3126085 0.935 rs12045496 chr1:152253910 A/G cg03465714 chr1:152285911 FLG -0.45 -5.56 -0.32 6.52e-8 Atopic dermatitis; CESC cis rs9611565 1.000 rs5751086 chr22:41768862 C/T cg03806693 chr22:41940476 POLR3H -0.56 -6.67 -0.38 1.51e-10 Vitiligo; CESC cis rs7937682 0.602 rs11214036 chr11:111773169 C/T cg09085632 chr11:111637200 PPP2R1B -0.92 -12.74 -0.62 2.61e-29 Primary sclerosing cholangitis; CESC cis rs10924309 0.889 rs10924307 chr1:245858125 C/T cg00036263 chr1:245852353 KIF26B -0.43 -5.26 -0.31 3.03e-7 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.05 0.3 8.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs79976124 0.876 rs17511913 chr6:66644361 C/T cg07460842 chr6:66804631 NA 0.69 8.07 0.44 2.5e-14 Type 2 diabetes; CESC cis rs9399137 0.507 rs4289677 chr6:135275485 A/G cg22676075 chr6:135203613 NA 0.54 6.98 0.39 2.38e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs4253772 0.530 rs715518 chr22:46754177 C/G cg10541313 chr22:46663664 TTC38 0.75 5.31 0.31 2.36e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4969178 0.930 rs7208596 chr17:76396528 C/G cg20026190 chr17:76395443 PGS1 0.49 7.81 0.43 1.34e-13 HDL cholesterol levels; CESC cis rs28489187 0.706 rs3087894 chr1:85787118 G/C cg16011679 chr1:85725395 C1orf52 0.56 6.55 0.37 3.05e-10 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs10789491 1.000 rs4660956 chr1:47158486 A/G cg15501359 chr1:47185051 KIAA0494 0.76 8.05 0.44 2.87e-14 Response to hepatitis C treatment; CESC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg08470875 chr2:26401718 FAM59B -0.47 -5.23 -0.31 3.38e-7 Gut microbiome composition (summer); CESC cis rs2637266 0.561 rs7090852 chr10:78499053 A/G cg18941641 chr10:78392320 NA -0.32 -5.1 -0.3 6.49e-7 Pulmonary function; CESC cis rs765787 0.530 rs12913123 chr15:45516425 C/T cg24006582 chr15:45444508 DUOX1 0.52 6.25 0.36 1.61e-9 Uric acid levels; CESC cis rs28374715 0.532 rs316604 chr15:41775221 C/T cg20272979 chr15:41787780 ITPKA 0.42 5.17 0.3 4.53e-7 Ulcerative colitis; CESC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.35 0.41 2.43e-12 Height; CESC cis rs11608355 0.545 rs35422737 chr12:109911456 A/G cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs10876993 0.928 rs2640637 chr12:58077586 G/A cg18357645 chr12:58087776 OS9 0.63 10.52 0.54 7.21e-22 Celiac disease or Rheumatoid arthritis; CESC cis rs12500824 0.564 rs7681311 chr4:77318829 G/A cg20311846 chr4:77356250 SHROOM3 0.39 7.5 0.42 9.73e-13 Coronary artery disease; CESC cis rs4568518 0.710 rs6955337 chr7:18014574 A/G cg03009463 chr7:17980271 SNX13 -0.46 -6.05 -0.35 4.98e-9 Measles; CESC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.31 0.31 2.28e-7 Menopause (age at onset); CESC trans rs10463316 0.894 rs7729216 chr5:150762277 A/G cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg18016565 chr1:150552671 MCL1 0.34 5.28 0.31 2.67e-7 Tonsillectomy; CESC cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg03060546 chr3:49711283 APEH 0.5 6.07 0.35 4.47e-9 Parkinson's disease; CESC cis rs3020736 0.500 rs6002601 chr22:42489058 A/T cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC cis rs11252926 0.599 rs11252213 chr10:454694 C/T cg16386425 chr10:429943 DIP2C -0.57 -7.25 -0.41 4.54e-12 Psychosis in Alzheimer's disease; CESC cis rs6752107 1.000 rs2289474 chr2:234181848 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.7 0.38 1.25e-10 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22242926 chr17:73627717 RECQL5 -0.57 -6.62 -0.38 1.98e-10 Gut microbiome composition (summer); CESC cis rs7264396 0.563 rs6058322 chr20:34367277 G/A cg23207816 chr20:34252616 CPNE1;RBM12 -0.68 -7.4 -0.41 1.83e-12 Total cholesterol levels; CESC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg07701084 chr6:150067640 NUP43 0.49 6.77 0.38 8.5e-11 Lung cancer; CESC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg18446336 chr7:2847575 GNA12 -0.37 -5.47 -0.32 1.05e-7 Height; CESC trans rs877282 0.583 rs11253424 chr10:813426 C/T cg22713356 chr15:30763199 NA 1.04 10.34 0.54 2.86e-21 Uric acid levels; CESC cis rs6466055 0.639 rs3823752 chr7:104624626 C/T cg04380332 chr7:105027541 SRPK2 -0.38 -5.42 -0.32 1.35e-7 Schizophrenia; CESC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.82 -0.34 1.69e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.51 0.37 3.76e-10 Bipolar disorder; CESC cis rs3820068 0.524 rs34094056 chr1:15824154 G/T cg17385448 chr1:15911702 AGMAT 0.41 6.33 0.36 1.02e-9 Systolic blood pressure; CESC cis rs6121246 0.909 rs8126355 chr20:30332660 C/T cg13852791 chr20:30311386 BCL2L1 0.82 8.74 0.47 2.63e-16 Mean corpuscular hemoglobin; CESC cis rs7084402 0.967 rs1649034 chr10:60279324 G/A cg07615347 chr10:60278583 BICC1 -0.6 -9.67 -0.51 3.77e-19 Refractive error; CESC cis rs1372520 0.873 rs983361 chr4:90761944 T/G cg15133208 chr4:90757351 SNCA -0.41 -5.63 -0.33 4.5e-8 Neuroticism; CESC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg09658497 chr7:2847517 GNA12 -0.39 -5.78 -0.33 2.14e-8 Height; CESC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.58 -0.42 5.91e-13 Gut microbiome composition (summer); CESC cis rs7607369 0.719 rs7567622 chr2:219624549 A/T cg02176678 chr2:219576539 TTLL4 -0.44 -7.77 -0.43 1.74e-13 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs11249608 0.548 rs13156530 chr5:178475017 C/T cg01312482 chr5:178451176 ZNF879 -0.45 -6.1 -0.35 3.72e-9 Pubertal anthropometrics; CESC cis rs9811920 0.638 rs793474 chr3:99544380 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.56 6.92 0.39 3.46e-11 Axial length; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03146981 chr16:70719277 MTSS1L -0.47 -6.79 -0.38 7.26e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6088590 0.710 rs6059992 chr20:33282275 T/C cg08999081 chr20:33150536 PIGU 0.65 10.71 0.55 1.77e-22 Coronary artery disease; CESC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.68 -0.33 3.49e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2652822 0.554 rs11635698 chr15:63478573 G/A cg02713581 chr15:63449717 RPS27L 0.52 6.69 0.38 1.34e-10 Metabolic traits; CESC cis rs1823874 0.581 rs12910401 chr15:100339897 T/C cg16400843 chr15:100339927 C15orf51 0.32 5.03 0.3 9.21e-7 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06197760 chr6:7585736 DSP -0.56 -6.26 -0.36 1.5e-9 Gut microbiome composition (summer); CESC cis rs6088590 1.000 rs6119516 chr20:33328024 C/T cg08999081 chr20:33150536 PIGU 0.59 9.1 0.49 2.28e-17 Coronary artery disease; CESC cis rs17253792 0.822 rs12323476 chr14:56172722 C/T cg24579896 chr14:56047964 C14orf33;KTN1 -0.68 -5.96 -0.34 8.09e-9 Putamen volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11564601 chr22:30592435 NA -0.4 -6.63 -0.38 1.92e-10 Gut microbiota (bacterial taxa); CESC trans rs11098499 0.866 rs7665125 chr4:120402079 G/T cg25214090 chr10:38739885 LOC399744 0.61 8.78 0.47 2.06e-16 Corneal astigmatism; CESC cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -9.08 -0.49 2.66e-17 Mean corpuscular volume; CESC cis rs6062302 0.522 rs2872810 chr20:62241931 C/T cg06363034 chr20:62225388 GMEB2 0.5 6.35 0.36 9.49e-10 Glioblastoma; CESC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.59 8.46 0.46 1.83e-15 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02986938 chr1:174968958 CACYBP 0.6 6.77 0.38 8.31e-11 Gut microbiome composition (summer); CESC cis rs7264396 0.563 rs6058296 chr20:34269225 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.83 0.34 1.58e-8 Total cholesterol levels; CESC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg04546413 chr19:29218101 NA 0.56 7.91 0.44 6.84e-14 Methadone dose in opioid dependence; CESC cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg05347473 chr6:146136440 FBXO30 -0.75 -9.55 -0.51 8.95e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs10832963 0.924 rs10832950 chr11:18635815 A/G cg09201001 chr11:18656081 SPTY2D1 0.82 12.36 0.6 5.21e-28 Breast cancer; CESC cis rs897984 0.542 rs4468641 chr16:31096876 A/C cg02466173 chr16:30829666 NA -0.4 -6.81 -0.39 6.65e-11 Dementia with Lewy bodies; CESC cis rs763121 0.853 rs7289577 chr22:39042214 C/G cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC cis rs8072100 0.676 rs9905308 chr17:45409386 T/A cg08085267 chr17:45401833 C17orf57 -0.65 -8.88 -0.48 1e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg07507251 chr3:52567010 NT5DC2 0.37 6.71 0.38 1.19e-10 Electroencephalogram traits; CESC cis rs2637266 0.756 rs7079818 chr10:78469935 T/A cg18941641 chr10:78392320 NA 0.44 8.25 0.45 7.25e-15 Pulmonary function; CESC cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg26597838 chr10:835615 NA 0.7 6.39 0.37 7.54e-10 Eosinophil percentage of granulocytes; CESC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg16606324 chr3:10149918 C3orf24 0.41 5.21 0.3 3.84e-7 Alzheimer's disease; CESC cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg05340658 chr4:99064831 C4orf37 0.8 12.43 0.61 3.04e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2836633 1.000 rs2836631 chr21:40065906 G/T cg05519781 chr21:40033154 ERG -0.59 -9.5 -0.5 1.28e-18 Coronary artery disease; CESC cis rs4722166 0.630 rs12700390 chr7:22777129 G/T cg05472934 chr7:22766657 IL6 0.87 10.94 0.56 3.06e-23 Lung cancer; CESC cis rs9905704 0.647 rs9901655 chr17:56987142 G/A cg12560992 chr17:57184187 TRIM37 0.58 7.05 0.4 1.52e-11 Testicular germ cell tumor; CESC cis rs2228479 0.850 rs11646766 chr16:89838578 A/T cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs7666738 0.606 rs28625338 chr4:99076996 A/G cg24818145 chr4:99064322 C4orf37 0.4 5.25 0.31 3.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs113835537 0.529 rs57207756 chr11:66270360 C/T cg22134325 chr11:66188745 NPAS4 0.46 7.13 0.4 9.52e-12 Airway imaging phenotypes; CESC cis rs8005677 1.000 rs8016061 chr14:23375809 A/G cg25600027 chr14:23388339 RBM23 -0.41 -5.04 -0.3 8.45e-7 Cognitive ability (multi-trait analysis); CESC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Tonsillectomy; CESC cis rs34779708 0.966 rs17591163 chr10:35465279 G/C cg03585969 chr10:35415529 CREM 0.77 10.33 0.54 2.96e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs863345 0.565 rs6679056 chr1:158450314 A/G cg12129480 chr1:158549410 OR10X1 -0.34 -6.73 -0.38 1.06e-10 Pneumococcal bacteremia; CESC cis rs8072100 0.967 rs4794058 chr17:45597098 C/T cg08085267 chr17:45401833 C17orf57 0.42 5.47 0.32 1.03e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs12586317 0.547 rs2254990 chr14:35465565 T/C cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC cis rs6964587 0.967 rs10280620 chr7:91582183 C/G cg17063962 chr7:91808500 NA -0.57 -7.68 -0.43 3.06e-13 Breast cancer; CESC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.64 -0.33 4.29e-8 Aortic root size; CESC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg18758796 chr5:131593413 PDLIM4 0.39 5.33 0.31 2.15e-7 Acylcarnitine levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15340270 chr11:62420901 INTS5 -0.45 -6.16 -0.35 2.72e-9 Gut microbiota (bacterial taxa); CESC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC trans rs7618501 1.000 rs1491986 chr3:49739086 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.34 -0.46 4.21e-15 Intelligence (multi-trait analysis); CESC cis rs950776 0.518 rs12915428 chr15:78823368 G/A cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC trans rs7922314 0.571 rs7083998 chr10:64750962 G/A cg06935979 chr1:232941706 KIAA1383 -0.62 -6.0 -0.35 6.34e-9 Cutaneous psoriasis; CESC cis rs3857067 1.000 rs2199603 chr4:95016174 G/A cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.03 -0.44 3.2e-14 QT interval; CESC cis rs796364 0.806 rs11691873 chr2:200966337 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -6.49 -0.37 4.2e-10 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23946709 chr14:23527317 CDH24 -0.49 -6.59 -0.38 2.41e-10 Fibrinogen levels; CESC trans rs4950322 0.518 rs11811023 chr1:146581118 C/T cg04954894 chr8:38089920 DDHD2 0.58 6.41 0.37 6.72e-10 Protein quantitative trait loci; CESC cis rs11122272 0.735 rs2491412 chr1:231535880 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -6.59 -0.38 2.31e-10 Hemoglobin concentration; CESC cis rs9788682 0.747 rs12101809 chr15:78779801 C/T cg24631222 chr15:78858424 CHRNA5 0.62 7.22 0.41 5.34e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs698833 0.729 rs4952708 chr2:44517072 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.67 0.33 3.65e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs11122272 0.735 rs2491416 chr1:231547335 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.52 6.95 0.39 2.84e-11 Hemoglobin concentration; CESC cis rs4803468 0.967 rs4605279 chr19:41888131 C/G cg14132834 chr19:41945861 ATP5SL -0.61 -7.61 -0.42 4.85e-13 Height; CESC cis rs7555523 0.887 rs7518099 chr1:165736880 C/T cg24409356 chr1:165738333 TMCO1 0.98 8.91 0.48 8.52e-17 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg03538708 chr1:25844672 NA -0.36 -5.29 -0.31 2.62e-7 Erythrocyte sedimentation rate; CESC cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg05347473 chr6:146136440 FBXO30 -0.55 -6.97 -0.39 2.54e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs1111541 chr4:99033860 A/G cg03467027 chr4:99064603 C4orf37 -0.46 -5.76 -0.33 2.31e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.4 0.31 1.47e-7 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15920017 chr6:90062628 UBE2J1 0.55 6.62 0.38 1.93e-10 Gut microbiome composition (summer); CESC cis rs9399137 0.507 rs4580893 chr6:135297662 G/A cg22676075 chr6:135203613 NA 0.54 7.06 0.4 1.46e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg05347473 chr6:146136440 FBXO30 0.54 6.84 0.39 5.31e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg25072359 chr17:41440525 NA 0.47 6.34 0.36 9.98e-10 Menopause (age at onset); CESC cis rs6815814 0.950 rs5743795 chr4:38832495 C/T cg02016764 chr4:38805732 TLR1 -0.61 -6.86 -0.39 4.8e-11 Breast cancer; CESC cis rs941873 0.868 rs4980063 chr10:81105844 A/T cg09469691 chr10:81107165 PPIF 0.57 7.89 0.44 7.81e-14 Height; CESC cis rs3815700 1.000 rs10406750 chr19:33097144 C/T cg24916020 chr19:33096688 ANKRD27 0.59 5.87 0.34 1.28e-8 Eosinophilic esophagitis; CESC cis rs9837602 0.529 rs793459 chr3:99520591 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.52 -6.21 -0.36 2.05e-9 Breast cancer; CESC cis rs9303401 0.592 rs66583824 chr17:56639853 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.93 0.62 5.59e-30 Cognitive test performance; CESC trans rs11098499 0.913 rs10006304 chr4:120124305 A/G cg25214090 chr10:38739885 LOC399744 0.62 8.24 0.45 7.91e-15 Corneal astigmatism; CESC cis rs79976124 0.837 rs75346757 chr6:66648386 A/T cg07460842 chr6:66804631 NA 0.75 8.76 0.47 2.33e-16 Type 2 diabetes; CESC cis rs1153858 1.000 rs1820518 chr15:45694579 C/T cg21132104 chr15:45694354 SPATA5L1 0.86 11.67 0.58 1.14e-25 Homoarginine levels; CESC cis rs793571 0.590 rs474875 chr15:59086703 A/C cg05156742 chr15:59063176 FAM63B 0.62 8.33 0.46 4.31e-15 Schizophrenia; CESC cis rs7177699 0.526 rs7166764 chr15:79123509 T/G cg04896959 chr15:78267971 NA -0.31 -5.05 -0.3 8.13e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs7267979 1.000 rs4813566 chr20:25386465 G/T cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.85e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9733 0.688 rs12725667 chr1:150766070 A/T cg22823121 chr1:150693482 HORMAD1 -0.38 -5.76 -0.33 2.33e-8 Tonsillectomy; CESC cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 5.83 0.34 1.64e-8 Personality dimensions; CESC trans rs561341 1.000 rs550923 chr17:30327013 G/C cg27661571 chr11:113659931 NA -0.82 -7.63 -0.42 4.18e-13 Hip circumference adjusted for BMI; CESC cis rs7267979 1.000 rs6050626 chr20:25428261 T/C cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.42e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg23161317 chr6:28129485 ZNF389 0.49 6.19 0.36 2.28e-9 Parkinson's disease; CESC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg00359181 chr2:38893519 GALM -0.64 -8.99 -0.48 4.95e-17 5-HTT brain serotonin transporter levels; CESC cis rs7927771 0.864 rs755555 chr11:47431966 C/T cg18512352 chr11:47633146 NA -0.5 -7.07 -0.4 1.37e-11 Subjective well-being; CESC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.47e-9 Total body bone mineral density; CESC cis rs9611565 0.659 rs9611604 chr22:41916001 C/G cg06481639 chr22:41940642 POLR3H -0.64 -6.58 -0.37 2.43e-10 Vitiligo; CESC cis rs10751667 0.666 rs7103585 chr11:971166 T/C cg06064525 chr11:970664 AP2A2 -0.47 -9.13 -0.49 1.87e-17 Alzheimer's disease (late onset); CESC cis rs10754283 0.934 rs10493829 chr1:90117833 T/C cg21401794 chr1:90099060 LRRC8C 0.71 9.51 0.5 1.26e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg26597838 chr10:835615 NA 1.19 11.34 0.57 1.41e-24 Eosinophil percentage of granulocytes; CESC cis rs8018808 0.935 rs2091916 chr14:77914752 A/G cg20045696 chr14:77926864 AHSA1 0.42 5.79 0.33 2.04e-8 Myeloid white cell count; CESC cis rs9467711 0.606 rs9393714 chr6:26373740 G/T cg14345882 chr6:26364793 BTN3A2 0.61 6.45 0.37 5.32e-10 Autism spectrum disorder or schizophrenia; CESC cis rs7818688 0.654 rs896848 chr8:95981810 G/A cg16049864 chr8:95962084 TP53INP1 0.5 5.45 0.32 1.17e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs17433780 0.504 rs4142706 chr1:89475230 A/C cg09516651 chr1:89888402 LOC400759 0.4 5.63 0.33 4.67e-8 Carotid intima media thickness; CESC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg17724175 chr1:150552817 MCL1 0.41 6.19 0.36 2.26e-9 Melanoma; CESC cis rs244293 0.965 rs244352 chr17:53195478 C/T cg19360675 chr17:53046073 COX11;STXBP4 0.4 5.22 0.31 3.56e-7 Menarche (age at onset); CESC cis rs12497850 0.931 rs7616815 chr3:48779715 C/T cg07636037 chr3:49044803 WDR6 0.94 16.47 0.71 1.91e-42 Parkinson's disease; CESC cis rs7647973 0.626 rs2131108 chr3:49665390 C/T cg13072238 chr3:49761600 GMPPB -0.44 -5.45 -0.32 1.17e-7 Menarche (age at onset); CESC cis rs2439831 0.867 rs486301 chr15:43836949 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.72 9.54 0.51 9.52e-19 Lung cancer in ever smokers; CESC trans rs7839040 0.698 rs17715625 chr8:82927562 G/A cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs11677370 0.574 rs10190477 chr2:3862738 A/G cg17052675 chr2:3827356 NA 0.45 5.73 0.33 2.71e-8 Type 2 diabetes; CESC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg09699651 chr6:150184138 LRP11 0.45 5.67 0.33 3.7e-8 Lung cancer; CESC cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg05340658 chr4:99064831 C4orf37 -0.83 -12.44 -0.61 2.73e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11696739 0.761 rs2254458 chr20:1551485 C/T cg25189608 chr11:96117844 CCDC82 0.4 6.18 0.35 2.35e-9 Mean platelet volume; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17748167 chr1:31769917 ZCCHC17;SNRNP40 0.44 6.26 0.36 1.56e-9 Gut microbiota (bacterial taxa); CESC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg06873352 chr17:61820015 STRADA 0.72 12.37 0.6 4.8e-28 Prudent dietary pattern; CESC cis rs2124969 0.506 rs10497210 chr2:160985549 G/A cg03641300 chr2:160917029 PLA2R1 -0.55 -5.59 -0.32 5.59e-8 Waist circumference adjusted for body mass index; CESC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg24503407 chr1:205819492 PM20D1 0.83 13.14 0.63 1.04e-30 Menarche (age at onset); CESC cis rs77956314 0.515 rs4767473 chr12:117365506 C/T cg16111737 chr12:117408163 FBXW8 -0.47 -5.85 -0.34 1.47e-8 Subcortical brain region volumes;Hippocampal volume; CESC cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7336332 0.662 rs9581862 chr13:28039993 T/G cg01674679 chr13:27998804 GTF3A -0.55 -5.89 -0.34 1.17e-8 Weight; CESC cis rs11249608 0.548 rs7707587 chr5:178462590 G/C cg21905437 chr5:178450457 ZNF879 0.58 8.12 0.45 1.81e-14 Pubertal anthropometrics; CESC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg07507251 chr3:52567010 NT5DC2 0.42 7.37 0.41 2.24e-12 Bipolar disorder; CESC cis rs7917772 0.582 rs6584512 chr10:104329685 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.61 0.33 5.05e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs72945132 0.882 rs7937984 chr11:70144254 C/T cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs7772486 0.790 rs2265918 chr6:146219164 A/G cg23711669 chr6:146136114 FBXO30 0.92 13.36 0.63 1.78e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs12477438 0.798 rs2309524 chr2:99659510 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.76 -10.94 -0.56 3.02e-23 Chronic sinus infection; CESC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg26769984 chr7:1090371 C7orf50 0.55 6.32 0.36 1.13e-9 Bronchopulmonary dysplasia; CESC cis rs7662987 0.517 rs3018048 chr4:100005538 C/T cg12011299 chr4:100065546 ADH4 0.59 6.71 0.38 1.18e-10 Smoking initiation; CESC cis rs7511006 1.000 rs5771109 chr22:50678571 T/C cg16473166 chr22:50639996 SELO 0.52 6.41 0.37 6.48e-10 Obesity-related traits; CESC cis rs826838 0.802 rs10785619 chr12:38742897 T/A cg26384229 chr12:38710491 ALG10B 0.66 11.32 0.57 1.69e-24 Heart rate; CESC cis rs2742234 0.541 rs10899779 chr10:43723976 C/T cg15436174 chr10:43711423 RASGEF1A 0.47 5.5 0.32 8.97e-8 Hirschsprung disease; CESC cis rs7909791 0.606 rs3814219 chr10:105647095 A/G cg24587175 chr10:105670608 OBFC1 -0.42 -6.08 -0.35 4.13e-9 White matter hyperintensity burden; CESC cis rs2425143 0.730 rs6058354 chr20:34491110 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.7 0.33 3.16e-8 Blood protein levels; CESC cis rs10883723 0.775 rs2296579 chr10:104241375 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.56 7.66 0.43 3.52e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs2243480 1.000 rs7794661 chr7:65389730 T/C cg12463550 chr7:65579703 CRCP 0.7 5.59 0.32 5.52e-8 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12448664 chr15:85143675 ZSCAN2 -0.61 -7.1 -0.4 1.13e-11 Gut microbiome composition (summer); CESC cis rs561341 0.825 rs2008368 chr17:30347397 T/C cg23018236 chr17:30244563 NA -0.55 -5.16 -0.3 4.77e-7 Hip circumference adjusted for BMI; CESC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg16325326 chr1:53192061 ZYG11B 0.84 13.71 0.64 1.03e-32 Monocyte count; CESC cis rs1692580 0.840 rs262679 chr1:2169792 C/T cg04315214 chr1:2043799 PRKCZ -0.38 -5.41 -0.32 1.41e-7 Coronary artery disease; CESC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 11.81 0.59 3.97e-26 Alzheimer's disease; CESC cis rs798766 1.000 rs798754 chr4:1720757 A/G cg10756475 chr4:1757242 NA 0.45 6.3 0.36 1.23e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs11718455 0.960 rs13065591 chr3:43996585 T/C cg08738300 chr3:44038990 NA 0.44 5.73 0.33 2.75e-8 Coronary artery disease; CESC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg02018176 chr4:1364513 KIAA1530 0.61 7.87 0.44 9.2e-14 Longevity; CESC cis rs7605827 0.930 rs13035937 chr2:15698050 C/T cg19274914 chr2:15703543 NA -0.35 -6.36 -0.36 9.01e-10 Educational attainment (years of education); CESC cis rs7640424 0.754 rs182736 chr3:107838891 C/A cg09227934 chr3:107805635 CD47 0.48 5.99 0.35 6.9e-9 Body mass index; CESC cis rs36051895 0.632 rs11788164 chr9:5129395 A/G cg02405213 chr9:5042618 JAK2 -0.51 -6.29 -0.36 1.31e-9 Pediatric autoimmune diseases; CESC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg01874867 chr7:94954059 PON1 -0.42 -6.36 -0.36 8.62e-10 Paraoxonase activity; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg16595246 chr2:48009933 MSH6 0.5 6.46 0.37 5e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11155671 0.530 rs9969044 chr6:150209204 A/G cg09699651 chr6:150184138 LRP11 0.55 7.44 0.42 1.41e-12 Testicular germ cell tumor; CESC cis rs977987 0.778 rs4888413 chr16:75443223 C/A cg03315344 chr16:75512273 CHST6 0.41 5.86 0.34 1.35e-8 Dupuytren's disease; CESC cis rs5758659 0.714 rs6002607 chr22:42496506 C/T cg00645731 chr22:42541494 CYP2D7P1 0.34 5.87 0.34 1.28e-8 Cognitive function; CESC cis rs7246657 0.943 rs10406177 chr19:37907947 G/A cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.81e-9 Coronary artery calcification; CESC cis rs6867032 0.958 rs4246754 chr5:2014776 A/C cg26168224 chr5:2018326 NA 0.87 15.8 0.7 4.38e-40 Gut microbiome composition (winter); CESC cis rs9487051 0.714 rs7774390 chr6:109602461 C/G cg01475377 chr6:109611718 NA 0.44 6.89 0.39 4.15e-11 Reticulocyte fraction of red cells; CESC cis rs6565180 0.926 rs12446288 chr16:30388709 A/G cg17640201 chr16:30407289 ZNF48 0.97 16.51 0.71 1.34e-42 Tonsillectomy; CESC cis rs6598955 0.640 rs4233460 chr1:26633387 A/G cg00852783 chr1:26633632 UBXN11 0.43 6.18 0.36 2.35e-9 Obesity-related traits; CESC cis rs6991838 0.584 rs4737749 chr8:66539907 A/C cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs870825 0.616 rs28673855 chr4:185627416 T/G cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs7474896 0.583 rs11011347 chr10:38019264 G/A cg00409905 chr10:38381863 ZNF37A -0.49 -5.6 -0.33 5.42e-8 Obesity (extreme); CESC cis rs7208859 0.623 rs7208088 chr17:29143667 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg17949981 chr6:28129498 ZNF389 0.42 5.24 0.31 3.27e-7 Depression; CESC cis rs7503807 0.688 rs901062 chr17:78595674 C/T cg09596252 chr17:78655493 RPTOR 0.37 5.2 0.3 4.03e-7 Obesity; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16216227 chr4:174293382 SAP30 0.38 6.19 0.36 2.26e-9 Gambling; CESC cis rs1983170 1.000 rs597288 chr1:91999296 C/T cg02896835 chr1:92012615 NA 0.57 6.54 0.37 3.13e-10 Eosinophil percentage of white cells; CESC cis rs2228479 1.000 rs62052186 chr16:89969567 A/T cg04013166 chr16:89971882 TCF25 0.75 6.27 0.36 1.47e-9 Skin colour saturation; CESC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs59918340 0.728 rs10875467 chr8:142233396 A/C cg16341495 chr8:142228727 SLC45A4 0.43 5.31 0.31 2.28e-7 Immature fraction of reticulocytes; CESC cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg02079420 chr8:82753780 SNX16 -0.54 -8.24 -0.45 8.22e-15 Diastolic blood pressure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19137606 chr10:38146164 ZNF248 -0.48 -6.85 -0.39 5.02e-11 Gut microbiota (bacterial taxa); CESC cis rs1348850 0.914 rs10497503 chr2:178371739 G/T cg22681709 chr2:178499509 PDE11A -0.42 -6.32 -0.36 1.13e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.16 0.35 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs977987 0.966 rs11643207 chr16:75498793 C/T cg03315344 chr16:75512273 CHST6 0.54 7.92 0.44 6.39e-14 Dupuytren's disease; CESC cis rs17764205 0.929 rs10401854 chr19:3256318 T/C cg04171554 chr19:2761892 SGTA -0.55 -5.15 -0.3 4.97e-7 Bipolar disorder and schizophrenia; CESC cis rs7508679 1.000 rs7508679 chr19:7222832 A/G cg09779027 chr19:7224513 INSR 0.54 8.73 0.47 3e-16 Hypothyroidism; CESC cis rs9649465 1.000 rs2896334 chr7:123367705 A/C cg04330084 chr7:123175371 IQUB -0.38 -5.13 -0.3 5.55e-7 Migraine; CESC cis rs10129255 0.957 rs6576233 chr14:107195477 G/A cg23076370 chr14:107095027 NA -0.55 -7.06 -0.4 1.49e-11 Kawasaki disease; CESC cis rs10927875 0.596 rs1806990 chr1:16129377 G/A cg21385522 chr1:16154831 NA -1.03 -16.9 -0.72 5.51e-44 Dilated cardiomyopathy; CESC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg18402987 chr7:1209562 NA 0.55 6.71 0.38 1.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg18230493 chr5:56204884 C5orf35 0.71 8.5 0.46 1.42e-15 Initial pursuit acceleration; CESC cis rs62064224 0.720 rs8078837 chr17:30763537 A/G cg09324608 chr17:30823087 MYO1D 0.53 8.2 0.45 1.08e-14 Schizophrenia; CESC cis rs1256061 0.603 rs1269056 chr14:64743890 T/C cg23250157 chr14:64679961 SYNE2 0.53 7.62 0.42 4.61e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7116495 1.000 rs493065 chr11:71796929 T/C cg10381502 chr11:71823885 C11orf51 -0.66 -5.4 -0.31 1.51e-7 Severe influenza A (H1N1) infection; CESC cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg12927641 chr6:109611667 NA -0.41 -6.43 -0.37 5.98e-10 Reticulocyte fraction of red cells; CESC cis rs11785400 0.753 rs9694286 chr8:143737157 G/T cg10596483 chr8:143751796 JRK 0.43 5.45 0.32 1.14e-7 Schizophrenia; CESC cis rs3806843 0.933 rs2337987 chr5:140188383 T/G cg26395211 chr5:140044315 WDR55 -0.41 -5.19 -0.3 4.17e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1707322 0.964 rs785496 chr1:46588006 T/C cg05343316 chr1:45956843 TESK2 -0.47 -5.52 -0.32 7.97e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg02807482 chr3:125708958 NA -0.39 -5.07 -0.3 7.59e-7 Blood pressure (smoking interaction); CESC cis rs67072384 1.000 rs72966113 chr11:72450970 C/T cg04827223 chr11:72435913 ARAP1 -0.71 -6.85 -0.39 5e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg02569458 chr12:86230093 RASSF9 0.49 7.62 0.42 4.61e-13 Major depressive disorder; CESC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.64 -0.51 4.83e-19 Alzheimer's disease; CESC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg14926445 chr8:58193284 C8orf71 -0.5 -5.4 -0.31 1.49e-7 Developmental language disorder (linguistic errors); CESC cis rs6120849 0.754 rs8501 chr20:33590584 T/C cg24642439 chr20:33292090 TP53INP2 0.67 6.62 0.38 1.94e-10 Protein C levels; CESC cis rs4319547 0.915 rs3803005 chr12:123110654 T/C cg23029597 chr12:123009494 RSRC2 -0.46 -5.12 -0.3 5.93e-7 Body mass index; CESC cis rs8114671 0.839 rs2104084 chr20:33649217 G/C cg06115741 chr20:33292138 TP53INP2 -0.43 -5.15 -0.3 5.03e-7 Height; CESC cis rs28647808 0.786 rs4962134 chr9:136256626 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs2742417 0.603 rs2742453 chr3:45765858 G/A cg04837898 chr3:45731254 SACM1L -0.47 -6.17 -0.35 2.54e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg26335602 chr6:28129616 ZNF389 0.41 5.57 0.32 6.18e-8 Parkinson's disease; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg08974656 chr2:96931567 CIAO1;TMEM127 0.55 6.53 0.37 3.33e-10 Psoriatic arthritis; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg21605566 chr1:14075549 PRDM2 -0.46 -6.11 -0.35 3.59e-9 Thyroid stimulating hormone; CESC cis rs7589342 0.839 rs1465641 chr2:106438936 C/T cg16077055 chr2:106428750 NCK2 0.48 6.88 0.39 4.33e-11 Addiction; CESC cis rs4843747 0.671 rs4072871 chr16:88106614 C/T cg06915872 chr16:87998081 BANP 0.44 5.26 0.31 3.03e-7 Menopause (age at onset); CESC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg22143856 chr6:28129313 ZNF389 0.5 6.49 0.37 4.09e-10 Depression; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg17832212 chr1:33367304 TMEM54 -0.51 -6.4 -0.37 7.07e-10 Asthma; CESC cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 6.67 0.38 1.46e-10 Mean platelet volume; CESC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg20578329 chr17:80767326 TBCD -0.69 -7.43 -0.42 1.51e-12 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC trans rs7246760 0.748 rs73507210 chr19:9885891 A/G cg02900749 chr2:68251473 NA -0.76 -6.86 -0.39 4.73e-11 Pursuit maintenance gain; CESC trans rs62103177 0.810 rs62096745 chr18:77619135 A/G cg05926928 chr17:57297772 GDPD1 1.24 11.08 0.56 1.09e-23 Opioid sensitivity; CESC cis rs35306767 0.714 rs7072554 chr10:1090988 C/T cg26597838 chr10:835615 NA 0.49 5.19 0.3 4.16e-7 Eosinophil percentage of granulocytes; CESC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg13902645 chr11:5959945 NA -0.67 -9.57 -0.51 7.8e-19 DNA methylation (variation); CESC cis rs1218582 0.682 rs12046459 chr1:154912017 A/C cg06221963 chr1:154839813 KCNN3 -0.65 -10.68 -0.55 2.24e-22 Prostate cancer; CESC cis rs4727027 0.870 rs62507485 chr7:148764182 C/T cg23158103 chr7:148848205 ZNF398 -0.4 -6.44 -0.37 5.59e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs782590 0.967 rs58003472 chr2:55797507 T/C cg18811423 chr2:55921094 PNPT1 0.78 12.54 0.61 1.22e-28 Metabolic syndrome; CESC cis rs1595825 0.891 rs17520121 chr2:198898718 T/G cg10820045 chr2:198174542 NA 0.39 5.06 0.3 7.76e-7 Ulcerative colitis; CESC cis rs854765 0.583 rs6502622 chr17:17834691 A/G cg16928487 chr17:17741425 SREBF1 -0.56 -9.74 -0.51 2.28e-19 Total body bone mineral density; CESC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg24399712 chr22:39784796 NA -0.82 -10.89 -0.56 4.48e-23 Intelligence (multi-trait analysis); CESC cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.08 0.3 7.05e-7 Hip circumference adjusted for BMI; CESC cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg20476274 chr7:133979776 SLC35B4 0.64 9.32 0.5 4.57e-18 Mean platelet volume; CESC cis rs17253792 0.822 rs28478195 chr14:56047851 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.88 0.34 1.25e-8 Putamen volume; CESC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg12463550 chr7:65579703 CRCP -0.5 -6.32 -0.36 1.08e-9 Aortic root size; CESC cis rs55794721 0.509 rs4649085 chr1:25778832 G/A cg03538708 chr1:25844672 NA -0.41 -6.27 -0.36 1.48e-9 Plateletcrit;Mean corpuscular volume; CESC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg17372223 chr3:52568218 NT5DC2 0.42 6.47 0.37 4.63e-10 Bipolar disorder; CESC cis rs2404602 0.608 rs12911035 chr15:76606591 T/C cg22467129 chr15:76604101 ETFA -0.41 -6.33 -0.36 1.05e-9 Blood metabolite levels; CESC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg26818010 chr10:134567672 INPP5A -0.94 -11.42 -0.57 7.87e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7577696 0.597 rs2280968 chr2:32290040 G/T cg02381751 chr2:32503542 YIPF4 -0.42 -5.05 -0.3 8.32e-7 Inflammatory biomarkers; CESC trans rs3780486 0.629 rs10971439 chr9:33180813 C/T cg04842962 chr6:43655489 MRPS18A -0.59 -6.81 -0.39 6.7e-11 IgG glycosylation; CESC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg20151795 chr6:28129481 ZNF389 0.46 5.74 0.33 2.6e-8 Depression; CESC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.33 -0.31 2.07e-7 Lung cancer; CESC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg22143856 chr6:28129313 ZNF389 0.37 5.26 0.31 2.97e-7 Cardiac Troponin-T levels; CESC cis rs2839186 0.934 rs17182538 chr21:47705673 C/A cg10351095 chr21:47802916 PCNT -0.5 -6.77 -0.38 8.06e-11 Testicular germ cell tumor; CESC cis rs977987 0.806 rs7188231 chr16:75436561 T/C cg03315344 chr16:75512273 CHST6 0.4 5.82 0.34 1.66e-8 Dupuytren's disease; CESC cis rs13040088 0.935 rs62200158 chr20:61557906 C/T cg23096297 chr20:61557774 DIDO1 1.03 11.14 0.56 7.03e-24 Menopause (age at onset); CESC cis rs1577917 0.958 rs2121594 chr6:86576854 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.2 -0.36 2.18e-9 Response to antipsychotic treatment; CESC cis rs2732480 0.500 rs11168464 chr12:48602115 C/T cg24011408 chr12:48396354 COL2A1 0.43 6.11 0.35 3.5e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs208520 1.000 rs72882100 chr6:66981495 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.35 0.5 3.7e-18 Exhaled nitric oxide output; CESC cis rs2243480 1.000 rs35283677 chr7:65359233 C/T cg13147721 chr7:65941812 NA -0.9 -8.76 -0.47 2.35e-16 Diabetic kidney disease; CESC cis rs12618769 0.597 rs17031905 chr2:99070902 A/G cg10123293 chr2:99228465 UNC50 0.41 5.56 0.32 6.6e-8 Bipolar disorder; CESC cis rs6866344 0.570 rs11740283 chr5:178136440 T/C cg03877680 chr5:178157825 ZNF354A 0.83 10.16 0.53 1.07e-20 Neutrophil percentage of white cells; CESC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.02 -0.4 1.85e-11 Total body bone mineral density; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07017636 chr1:165567312 NA 0.47 6.46 0.37 5.05e-10 Systemic lupus erythematosus; CESC cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg05347473 chr6:146136440 FBXO30 0.73 9.27 0.49 6.59e-18 Lobe attachment (rater-scored or self-reported); CESC cis rs9581857 0.685 rs78595793 chr13:28031881 C/T cg22138327 chr13:27999177 GTF3A 0.63 5.09 0.3 6.92e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs4888262 0.564 rs6564147 chr16:74622586 G/A cg01733217 chr16:74700730 RFWD3 0.85 11.4 0.57 9.25e-25 Testicular germ cell tumor; CESC cis rs858239 0.669 rs1006709 chr7:23140099 C/T cg23682824 chr7:23144976 KLHL7 0.47 6.52 0.37 3.61e-10 Cerebrospinal fluid biomarker levels; CESC cis rs854765 0.583 rs11871899 chr17:17826748 C/G cg16928487 chr17:17741425 SREBF1 -0.58 -9.9 -0.52 7.25e-20 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24028381 chr8:145133668 EXOSC4 -0.44 -6.4 -0.37 7.19e-10 Fibrinogen levels; CESC trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg00717180 chr2:96193071 NA -0.53 -7.47 -0.42 1.17e-12 Coronary artery disease; CESC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg06219351 chr7:158114137 PTPRN2 -0.5 -7.84 -0.43 1.1e-13 Calcium levels; CESC cis rs1707322 1.000 rs11211237 chr1:46447329 G/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs208520 0.955 rs9453664 chr6:66976079 A/C cg07460842 chr6:66804631 NA 0.74 8.71 0.47 3.42e-16 Exhaled nitric oxide output; CESC cis rs16854884 0.683 rs920968 chr3:143770698 C/G cg06585982 chr3:143692056 C3orf58 0.51 6.52 0.37 3.54e-10 Economic and political preferences (feminism/equality); CESC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.27 0.76 2.4e-52 Height; CESC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.69 0.38 1.29e-10 Bipolar disorder; CESC cis rs1538970 0.781 rs11211139 chr1:46015751 G/T cg06784218 chr1:46089804 CCDC17 0.41 6.38 0.36 7.97e-10 Platelet count; CESC cis rs1801251 1.000 rs2305137 chr2:233712049 G/A cg08000102 chr2:233561755 GIGYF2 -0.68 -9.93 -0.52 5.99e-20 Coronary artery disease; CESC cis rs78456975 0.527 rs4073862 chr2:1563433 A/G cg26248373 chr2:1572462 NA -0.54 -6.48 -0.37 4.55e-10 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs1144333 1.000 rs1144333 chr1:76275100 A/G cg22875332 chr1:76189707 ACADM -0.55 -5.32 -0.31 2.22e-7 Attention function in attention deficit hyperactive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09513169 chr5:178287767 ZNF354B -0.65 -7.57 -0.42 6.29e-13 Gut microbiome composition (summer); CESC cis rs3820928 0.874 rs10194663 chr2:227875369 T/A cg05526886 chr2:227700861 RHBDD1 -0.44 -5.43 -0.32 1.3e-7 Pulmonary function; CESC cis rs17209837 0.646 rs4148818 chr7:87083738 T/C cg00919237 chr7:87102261 ABCB4 -0.51 -6.58 -0.37 2.45e-10 Gallbladder cancer; CESC cis rs7772486 0.623 rs9485021 chr6:146068797 A/G cg05347473 chr6:146136440 FBXO30 -0.52 -6.94 -0.39 3.01e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.754 rs12509621 chr4:120249660 T/C cg09307838 chr4:120376055 NA 0.77 10.49 0.54 9.15e-22 Corneal astigmatism; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg17561891 chr7:86849173 C7orf23 -0.44 -6.17 -0.35 2.51e-9 Breast cancer; CESC cis rs9616064 0.557 rs5767318 chr22:47048792 A/G cg05621596 chr22:47072043 GRAMD4 -0.68 -9.8 -0.52 1.45e-19 Urate levels in obese individuals; CESC cis rs3008870 0.959 rs2985810 chr1:67376162 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.05 14.57 0.67 9.8e-36 Lymphocyte percentage of white cells; CESC cis rs2228479 0.850 rs62054610 chr16:89816920 G/A cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs7084402 0.967 rs1621811 chr10:60320664 T/C cg07615347 chr10:60278583 BICC1 0.63 10.12 0.53 1.48e-20 Refractive error; CESC cis rs4319547 1.000 rs7307735 chr12:123087442 A/G cg23029597 chr12:123009494 RSRC2 -0.46 -5.26 -0.31 3.01e-7 Body mass index; CESC cis rs1595825 0.891 rs2045244 chr2:198506466 C/T cg00982548 chr2:198649783 BOLL -0.48 -5.12 -0.3 5.91e-7 Ulcerative colitis; CESC cis rs731174 0.959 rs12747993 chr1:38190852 T/C cg12339802 chr1:38156545 C1orf109 -0.54 -6.29 -0.36 1.34e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1697139 0.583 rs13186050 chr5:66528139 C/T cg11553311 chr5:66541588 NA 0.36 5.16 0.3 4.74e-7 Breast cancer; CESC trans rs208520 0.874 rs208518 chr6:66948501 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 9.86 0.52 9.56e-20 Exhaled nitric oxide output; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08687137 chr11:62389499 B3GAT3 -0.51 -6.38 -0.36 8.03e-10 Ulcerative colitis; CESC cis rs16854884 0.582 rs34402874 chr3:143643249 T/A cg06585982 chr3:143692056 C3orf58 0.53 6.54 0.37 3.23e-10 Economic and political preferences (feminism/equality); CESC cis rs7208859 0.623 rs58908911 chr17:29244558 C/T cg19761014 chr17:28927070 LRRC37B2 0.69 5.48 0.32 9.65e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2475553 0.520 rs62437129 chr6:158655757 T/G cg07165851 chr6:158734300 TULP4 0.59 5.54 0.32 7.29e-8 Lipoprotein (a) - cholesterol levels; CESC cis rs6782228 0.883 rs11712115 chr3:128404269 G/A cg15607142 chr3:128420513 NA -0.37 -5.08 -0.3 7.24e-7 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; CESC cis rs9916302 0.904 rs7501488 chr17:37576417 T/G cg15445000 chr17:37608096 MED1 0.4 6.5 0.37 3.93e-10 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.570 rs11097612 chr4:99079772 T/C cg17366294 chr4:99064904 C4orf37 0.43 5.77 0.33 2.15e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08180934 chr12:16035177 STRAP 0.57 6.31 0.36 1.19e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14838070 chr5:150030486 SYNPO 0.48 6.8 0.39 6.83e-11 Fibrinogen levels; CESC cis rs8072100 0.840 rs56952963 chr17:45493826 T/C cg25173405 chr17:45401733 C17orf57 -0.42 -5.53 -0.32 7.75e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9436747 0.585 rs11581702 chr1:65987659 T/C cg14976592 chr1:65886160 LEPROT;LEPR -0.42 -5.19 -0.3 4.21e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC trans rs9833726 0.860 rs9877300 chr3:85962170 C/T cg10416071 chr15:75628863 COMMD4 0.63 6.23 0.36 1.87e-9 Breast cancer; CESC cis rs13191362 0.935 rs35100164 chr6:162963003 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 7.7 0.43 2.75e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg08859206 chr1:53392774 SCP2 -0.65 -9.31 -0.5 5.23e-18 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22767408 chr2:230787493 TRIP12;FBXO36 0.54 6.09 0.35 3.85e-9 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs34779708 0.931 rs12268745 chr10:35305989 C/G cg04310649 chr10:35416472 CREM -0.51 -6.27 -0.36 1.5e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.27 0.63 3.65e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7927771 0.524 rs7107792 chr11:47669249 A/C cg20307385 chr11:47447363 PSMC3 0.62 8.79 0.48 1.96e-16 Subjective well-being; CESC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs9443189 0.570 rs529383 chr6:76297847 T/G cg01950844 chr6:76311363 SENP6 0.9 8.4 0.46 2.71e-15 Prostate cancer; CESC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg13628971 chr7:2884303 GNA12 0.64 8.49 0.46 1.5e-15 Height; CESC cis rs9811920 0.598 rs793470 chr3:99548274 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.42 5.43 0.32 1.27e-7 Axial length; CESC cis rs4835473 0.897 rs12505617 chr4:144644675 C/T cg25736465 chr4:144833511 NA 0.39 5.97 0.34 7.69e-9 Immature fraction of reticulocytes; CESC cis rs6762 0.692 rs7928925 chr11:839155 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.75 -9.83 -0.52 1.23e-19 Mean platelet volume; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09464028 chr2:128744380 SAP130 -0.45 -6.04 -0.35 5.23e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2273669 0.667 rs12214567 chr6:109317330 C/T cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs2070997 0.816 rs6597643 chr9:133725830 C/T cg11464064 chr9:133710261 ABL1 -0.52 -5.75 -0.33 2.49e-8 Response to amphetamines; CESC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg05313129 chr8:58192883 C8orf71 -0.53 -6.16 -0.35 2.66e-9 Developmental language disorder (linguistic errors); CESC cis rs7267979 0.549 rs6138537 chr20:25184466 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.57 8.52 0.46 1.24e-15 Liver enzyme levels (alkaline phosphatase); CESC cis rs9787249 0.533 rs1883649 chr1:40246549 C/T cg02773041 chr1:40204384 PPIE 0.39 5.6 0.33 5.33e-8 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12748608 chr7:931987 C7orf20 0.49 6.87 0.39 4.54e-11 Fibrinogen levels; CESC cis rs116161686 0.500 rs76610459 chr1:210050756 T/G cg22029157 chr1:209979665 IRF6 0.68 7.09 0.4 1.19e-11 Coronary artery disease; CESC cis rs75477785 0.590 rs72649912 chr1:210076950 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.96 6.81 0.39 6.53e-11 Cleft lip with or without cleft palate; CESC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg22535103 chr8:58192502 C8orf71 -0.84 -9.44 -0.5 2.04e-18 Developmental language disorder (linguistic errors); CESC cis rs72627123 0.867 rs80298117 chr14:74447383 G/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.79 5.35 0.31 1.9e-7 Morning vs. evening chronotype; CESC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg11644478 chr21:40555479 PSMG1 1.02 16.23 0.71 1.32e-41 Cognitive function; CESC cis rs7617773 0.780 rs34946886 chr3:48338487 A/G cg11946769 chr3:48343235 NME6 0.89 12.11 0.6 3.63e-27 Coronary artery disease; CESC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg13393036 chr8:95962371 TP53INP1 0.47 9.09 0.49 2.33e-17 Type 2 diabetes; CESC cis rs72781680 1.000 rs111229211 chr2:24167417 T/G cg08917208 chr2:24149416 ATAD2B 0.87 7.18 0.4 6.86e-12 Lymphocyte counts; CESC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg22963979 chr7:1858916 MAD1L1 -0.37 -5.23 -0.31 3.51e-7 Bipolar disorder and schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14320087 chr8:74005537 C8orf84 -0.45 -6.36 -0.36 8.9e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7512552 0.839 rs1625468 chr1:150321486 G/A cg15654264 chr1:150340011 RPRD2 0.39 5.12 0.3 5.94e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs4268898 0.636 rs72787371 chr2:24570073 T/A cg20701182 chr2:24300061 SF3B14 0.62 6.67 0.38 1.48e-10 Asthma; CESC cis rs4523957 0.651 rs9908373 chr17:2086534 G/A cg16513277 chr17:2031491 SMG6 -0.68 -9.37 -0.5 3.38e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs8072100 0.576 rs12948299 chr17:45403057 T/C cg08085267 chr17:45401833 C17orf57 -0.66 -8.04 -0.44 2.97e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6964587 1.000 rs13231820 chr7:91663529 A/G cg17063962 chr7:91808500 NA 0.54 7.17 0.4 7.61e-12 Breast cancer; CESC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg03806693 chr22:41940476 POLR3H -1.12 -13.95 -0.65 1.55e-33 Vitiligo; CESC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg11764359 chr7:65958608 NA 0.73 10.55 0.54 5.73e-22 Aortic root size; CESC trans rs208520 0.661 rs207099 chr6:66796373 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -12.91 -0.62 6.39e-30 Exhaled nitric oxide output; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20285559 chr1:6688542 THAP3 0.5 7.08 0.4 1.33e-11 Fibrinogen levels; CESC cis rs796364 0.951 rs7565005 chr2:201013277 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.63 -6.25 -0.36 1.59e-9 Schizophrenia; CESC cis rs6582630 0.615 rs10880642 chr12:38554152 A/G cg26384229 chr12:38710491 ALG10B -0.45 -6.1 -0.35 3.83e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg17971929 chr21:40555470 PSMG1 -0.54 -7.02 -0.4 1.86e-11 Menarche (age at onset); CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg23034840 chr1:205782522 SLC41A1 0.68 8.32 0.46 4.7e-15 Menarche (age at onset); CESC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.76 -0.38 8.6e-11 Parkinson's disease; CESC cis rs4919087 0.961 rs11189120 chr10:99069493 G/T cg25902810 chr10:99078978 FRAT1 0.72 10.73 0.55 1.48e-22 Monocyte count; CESC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg22907277 chr7:1156413 C7orf50 0.4 5.78 0.33 2.13e-8 Longevity;Endometriosis; CESC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg11764359 chr7:65958608 NA -0.73 -10.44 -0.54 1.38e-21 Aortic root size; CESC cis rs8044868 0.530 rs2288000 chr16:72058881 A/G cg16558253 chr16:72132732 DHX38 -0.37 -5.67 -0.33 3.8e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs17376456 1.000 rs13163610 chr5:93548877 A/C cg25358565 chr5:93447407 FAM172A 1.13 11.09 0.56 1e-23 Diabetic retinopathy; CESC cis rs1008375 0.966 rs4698638 chr4:17632988 G/C cg16339924 chr4:17578868 LAP3 0.56 7.13 0.4 9.83e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7267979 1.000 rs6083813 chr20:25337671 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.13 -0.74 2.42e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs4660306 0.961 rs1494813 chr1:45957290 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.86e-13 Homocysteine levels; CESC cis rs4728302 0.869 rs10224575 chr7:133590875 G/A cg10665199 chr7:133106180 EXOC4 0.39 5.39 0.31 1.55e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs4642101 0.640 rs12629398 chr3:12826799 A/G cg24848339 chr3:12840334 CAND2 0.41 6.39 0.37 7.25e-10 QRS complex (12-leadsum); CESC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg21138405 chr5:131827807 IRF1 0.36 5.23 0.31 3.43e-7 Breast cancer;Mosquito bite size; CESC cis rs80282103 0.867 rs17155821 chr10:1071701 A/G cg08668510 chr10:1095578 IDI1 0.66 5.27 0.31 2.78e-7 Glomerular filtration rate (creatinine); CESC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg18876405 chr7:65276391 NA -0.5 -6.58 -0.37 2.56e-10 Aortic root size; CESC cis rs12476592 0.571 rs2028883 chr2:63804531 G/A cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs881375 0.678 rs10760129 chr9:123700183 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.55 0.37 2.92e-10 Rheumatoid arthritis; CESC cis rs9837602 1.000 rs793499 chr3:99565576 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.55 -7.64 -0.42 3.94e-13 Breast cancer; CESC cis rs10489202 1.000 rs67600256 chr1:167972357 T/C cg24449463 chr1:168025552 DCAF6 -0.46 -5.3 -0.31 2.41e-7 Schizophrenia; CESC cis rs17376456 0.569 rs13186432 chr5:93336940 G/A cg25358565 chr5:93447407 FAM172A -0.45 -5.18 -0.3 4.43e-7 Diabetic retinopathy; CESC cis rs7212590 0.748 rs73315252 chr17:57854855 A/G cg20303301 chr17:57937339 TUBD1 -0.57 -5.36 -0.31 1.81e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg17178900 chr1:205818956 PM20D1 0.79 11.83 0.59 3.39e-26 Menarche (age at onset); CESC cis rs651907 0.514 rs12636047 chr3:101434449 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.88 0.34 1.22e-8 Colorectal cancer; CESC cis rs7116495 0.609 rs7111379 chr11:71826319 C/T cg10381502 chr11:71823885 C11orf51 1.06 6.8 0.39 6.99e-11 Severe influenza A (H1N1) infection; CESC cis rs3733585 0.631 rs4697924 chr4:10124239 A/G cg02734326 chr4:10020555 SLC2A9 -0.38 -5.06 -0.3 7.82e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7927771 0.524 rs10838763 chr11:47794802 C/T cg18512352 chr11:47633146 NA 0.33 5.17 0.3 4.51e-7 Subjective well-being; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25017976 chr1:154947060 CKS1B;SHC1 0.61 6.55 0.37 2.91e-10 Gut microbiome composition (summer); CESC cis rs7845219 0.544 rs9643350 chr8:95917276 C/A cg09323728 chr8:95962352 TP53INP1 -0.32 -6.22 -0.36 1.91e-9 Type 2 diabetes; CESC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg21226059 chr5:178986404 RUFY1 -0.52 -7.93 -0.44 6.12e-14 Lung cancer; CESC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg23590916 chr17:43697445 MGC57346 -0.64 -6.67 -0.38 1.45e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg18240062 chr17:79603768 NPLOC4 0.54 7.07 0.4 1.41e-11 Eye color traits; CESC cis rs2262909 1.000 rs436039 chr19:22214873 T/C cg11619707 chr19:22235551 ZNF257 -0.35 -5.7 -0.33 3.19e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg15990800 chr14:55738852 FBXO34 -0.47 -6.12 -0.35 3.31e-9 Height; CESC cis rs9814567 1.000 rs62271515 chr3:134300507 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.44 -0.32 1.21e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9790314 1.000 rs975323 chr3:161021322 A/G cg04691961 chr3:161091175 C3orf57 -0.44 -5.73 -0.33 2.74e-8 Morning vs. evening chronotype; CESC cis rs7762018 0.891 rs73242950 chr6:170144737 C/T cg13891659 chr6:170190454 C6orf122;C6orf208 0.67 6.66 0.38 1.61e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2732480 0.500 rs11168464 chr12:48602115 C/T cg04545296 chr12:48745243 ZNF641 0.4 6.74 0.38 9.66e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs1729951 0.575 rs2163896 chr3:136691177 G/A cg04103450 chr3:136751342 NA 0.4 5.31 0.31 2.32e-7 Neuroticism; CESC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg00431813 chr7:1051703 C7orf50 -0.35 -5.48 -0.32 9.75e-8 Longevity;Endometriosis; CESC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg21782813 chr7:2030301 MAD1L1 0.44 6.22 0.36 1.94e-9 Schizophrenia; CESC cis rs9527 0.590 rs7067663 chr10:104883650 A/G cg04362960 chr10:104952993 NT5C2 0.45 5.64 0.33 4.38e-8 Arsenic metabolism; CESC cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg03467027 chr4:99064603 C4orf37 0.48 6.05 0.35 4.87e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.61e-39 Menopause (age at onset); CESC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg22920501 chr2:26401640 FAM59B 0.66 7.88 0.44 8.33e-14 Gut microbiome composition (summer); CESC cis rs4481887 0.927 rs12044126 chr1:248481952 T/C cg00666640 chr1:248458726 OR2T12 0.36 6.07 0.35 4.47e-9 Common traits (Other); CESC cis rs75804782 0.641 rs72987328 chr2:239360097 C/T cg18131467 chr2:239335373 ASB1 -0.71 -5.83 -0.34 1.6e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg17221315 chr6:27791827 HIST1H4J 0.62 5.33 0.31 2.13e-7 Depression; CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg26354017 chr1:205819088 PM20D1 0.97 17.12 0.72 9.23e-45 Menarche (age at onset); CESC cis rs13102973 0.965 rs13126242 chr4:135860948 T/C cg14419869 chr4:135874104 NA 0.34 5.37 0.31 1.72e-7 Subjective well-being; CESC cis rs78456975 0.607 rs73909625 chr2:1541934 A/G cg01028140 chr2:1542097 TPO -0.61 -5.8 -0.34 1.88e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs2404602 0.679 rs12900494 chr15:76912504 A/G cg22467129 chr15:76604101 ETFA -0.36 -5.31 -0.31 2.34e-7 Blood metabolite levels; CESC cis rs7210086 0.768 rs4395115 chr17:70640382 G/C cg04206342 chr17:70636940 NA -0.28 -5.15 -0.3 5.13e-7 Ulcerative colitis; CESC cis rs6028335 0.674 rs16987779 chr20:37671455 C/T cg16355469 chr20:37678765 NA 0.52 5.15 0.3 5.19e-7 Alcohol and nicotine co-dependence; CESC cis rs727505 1.000 rs1541416 chr7:124450345 T/C cg23710748 chr7:124431027 NA -0.37 -5.9 -0.34 1.12e-8 Lewy body disease; CESC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg14926445 chr8:58193284 C8orf71 -0.5 -5.4 -0.31 1.49e-7 Developmental language disorder (linguistic errors); CESC cis rs4689388 0.750 rs10755148 chr4:6295064 A/G cg14416269 chr4:6271139 WFS1 0.43 6.6 0.38 2.21e-10 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs265548 0.538 rs36688 chr19:17911212 A/C cg21960279 chr19:17905606 B3GNT3 0.48 7.03 0.4 1.77e-11 Tumor biomarkers; CESC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg24675658 chr1:53192096 ZYG11B 0.53 6.78 0.38 7.96e-11 Monocyte count; CESC cis rs12681288 0.723 rs12545453 chr8:970582 C/T cg15309053 chr8:964076 NA 0.36 5.71 0.33 3.04e-8 Schizophrenia; CESC trans rs6089829 0.962 rs1060490 chr20:61665871 A/G cg23505145 chr19:12996616 KLF1 0.52 6.8 0.39 6.85e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs9399135 1.000 rs9399135 chr6:135368314 G/A cg24558204 chr6:135376177 HBS1L 0.5 6.8 0.39 6.76e-11 Red blood cell count; CESC cis rs959260 1.000 rs2117563 chr17:73368985 A/G cg20590849 chr17:73267439 MIF4GD -0.55 -6.44 -0.37 5.48e-10 Systemic lupus erythematosus; CESC cis rs72781680 0.716 rs17045975 chr2:24099611 A/T cg08917208 chr2:24149416 ATAD2B -0.55 -5.56 -0.32 6.61e-8 Lymphocyte counts; CESC cis rs9457247 1.000 rs430477 chr6:167389851 T/C cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 4.96e-16 Crohn's disease; CESC trans rs9319321 0.550 rs7324598 chr13:27414170 C/T cg14332112 chr6:47277683 TNFRSF21 -0.47 -6.03 -0.35 5.63e-9 Asthma (toluene diisocyanate-induced); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03170725 chr2:27498214 DNAJC5G -0.71 -7.76 -0.43 1.81e-13 Gut microbiome composition (summer); CESC cis rs4077515 0.935 rs3812565 chr9:139272502 T/C cg14169450 chr9:139327907 INPP5E 0.43 6.31 0.36 1.16e-9 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg18016565 chr1:150552671 MCL1 0.33 5.15 0.3 5.13e-7 Tonsillectomy; CESC cis rs4481887 0.893 rs1339990 chr1:248509495 C/T cg00666640 chr1:248458726 OR2T12 -0.33 -5.86 -0.34 1.35e-8 Common traits (Other); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04095345 chr6:34857663 ANKS1A 0.43 6.21 0.36 2.03e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2832191 0.632 rs1984011 chr21:30337831 T/A cg08807101 chr21:30365312 RNF160 -0.91 -14.09 -0.65 5.03e-34 Dental caries; CESC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg18016565 chr1:150552671 MCL1 0.34 5.23 0.31 3.46e-7 Melanoma; CESC cis rs6541297 0.555 rs910502 chr1:230294185 A/T cg20703242 chr1:230279135 GALNT2 0.65 7.07 0.4 1.41e-11 Coronary artery disease; CESC cis rs7945705 0.967 rs7943377 chr11:8848700 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.37 5.64 0.33 4.4e-8 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03108344 chr6:150326762 RAET1K 0.56 6.67 0.38 1.47e-10 Gut microbiome composition (summer); CESC cis rs72772090 0.520 rs56325109 chr5:96112295 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.05 -0.3 8.29e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9549367 0.789 rs7317558 chr13:113893625 G/A cg00898013 chr13:113819073 PROZ -0.52 -7.42 -0.41 1.59e-12 Platelet distribution width; CESC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg19592336 chr6:28129416 ZNF389 0.5 6.68 0.38 1.36e-10 Parkinson's disease; CESC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg27170947 chr2:26402098 FAM59B -0.6 -7.23 -0.41 5.28e-12 Gut microbiome composition (summer); CESC cis rs7131987 0.903 rs11050153 chr12:29405148 T/C cg09582351 chr12:29534625 ERGIC2 -0.33 -5.42 -0.32 1.34e-7 QT interval; CESC cis rs397969 0.570 rs2108981 chr17:19878666 G/A cg12073167 chr17:19770448 ULK2 -0.49 -5.88 -0.34 1.25e-8 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18075073 chr11:210610 RIC8A -0.55 -6.16 -0.35 2.67e-9 Gut microbiome composition (summer); CESC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg00745463 chr17:30367425 LRRC37B 0.57 5.68 0.33 3.63e-8 Hip circumference adjusted for BMI; CESC cis rs8180040 0.966 rs62260711 chr3:47564491 G/C cg27129171 chr3:47204927 SETD2 -0.61 -8.52 -0.46 1.23e-15 Colorectal cancer; CESC cis rs7246657 0.943 rs4969487 chr19:37831039 C/T cg23950597 chr19:37808831 NA -0.62 -6.37 -0.36 8.15e-10 Coronary artery calcification; CESC cis rs1153858 0.943 rs67045941 chr15:45677011 A/G cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs1874326 0.545 rs6467769 chr7:138109790 G/A cg18008034 chr7:138118925 NA -0.41 -5.14 -0.3 5.34e-7 Quantitative traits; CESC cis rs72634258 0.519 rs4908708 chr1:7938113 G/C cg00042356 chr1:8021962 PARK7 0.52 5.61 0.33 5.2100000000000003e-08 Inflammatory bowel disease; CESC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg08859206 chr1:53392774 SCP2 -0.57 -8.08 -0.44 2.3e-14 Monocyte count; CESC cis rs1018836 0.828 rs7014967 chr8:91557843 G/T cg16814680 chr8:91681699 NA -0.64 -9.15 -0.49 1.58e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs12477438 0.715 rs7586608 chr2:99558017 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -8.83 -0.48 1.48e-16 Chronic sinus infection; CESC cis rs4660261 0.526 rs803680 chr1:44364370 G/C cg12908607 chr1:44402522 ARTN -0.47 -6.93 -0.39 3.17e-11 Intelligence (multi-trait analysis); CESC cis rs6088580 0.634 rs2184836 chr20:32963369 A/G cg06115741 chr20:33292138 TP53INP2 -0.46 -5.96 -0.34 7.8e-9 Glomerular filtration rate (creatinine); CESC cis rs7772486 0.875 rs932522 chr6:146374026 A/G cg23711669 chr6:146136114 FBXO30 -0.86 -12.77 -0.62 2.02e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg03060546 chr3:49711283 APEH 0.5 5.99 0.35 6.84e-9 Parkinson's disease; CESC cis rs4888262 0.545 rs12716768 chr16:74556486 A/G cg01733217 chr16:74700730 RFWD3 -0.69 -8.56 -0.47 9.29e-16 Testicular germ cell tumor; CESC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg23590916 chr17:43697445 MGC57346 0.64 6.5 0.37 4.05e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs644799 1.000 rs564675 chr11:95561873 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.27 0.66 1.19e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7264396 0.563 rs2425120 chr20:34324456 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.88e-22 Total cholesterol levels; CESC cis rs9303401 0.573 rs35104446 chr17:57180234 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.93 11.67 0.58 1.16e-25 Cognitive test performance; CESC cis rs72945132 0.882 rs60780459 chr11:70162468 A/G cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs2573652 0.928 rs2581348 chr15:100514063 C/T cg00587665 chr15:100533223 ADAMTS17 -0.33 -5.35 -0.31 1.91e-7 Height; CESC cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.58 5.66 0.33 3.9e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs75477785 0.590 rs72649923 chr1:210130204 T/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.91 6.32 0.36 1.12e-9 Cleft lip with or without cleft palate; CESC cis rs17253792 0.915 rs77252471 chr14:56178075 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.73 5.13 0.3 5.7e-7 Putamen volume; CESC cis rs7903847 0.596 rs10882934 chr10:99170995 T/G cg20016023 chr10:99160130 RRP12 -0.3 -5.04 -0.3 8.7e-7 Granulocyte percentage of myeloid white cells; CESC cis rs1707322 0.964 rs6697830 chr1:46290477 C/A cg05343316 chr1:45956843 TESK2 0.41 5.05 0.3 8.05e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17293817 0.617 rs55820900 chr10:1410128 A/G cg04271617 chr10:1416546 ADARB2 0.34 5.13 0.3 5.71e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9948 0.529 rs62156208 chr2:97383686 A/G cg01990225 chr2:97406019 LMAN2L -0.99 -7.31 -0.41 3.23e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg03240473 chr21:43526662 UMODL1;C21orf128 -0.41 -5.16 -0.3 4.77e-7 IgG glycosylation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21962918 chr5:134094454 DDX46 -0.47 -6.55 -0.37 2.95e-10 Fibrinogen levels; CESC cis rs11098499 0.954 rs59866101 chr4:120296591 T/G cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs3741151 0.686 rs11823913 chr11:73141627 C/G cg17517138 chr11:73019481 ARHGEF17 0.62 5.33 0.31 2.15e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC cis rs1728785 1.000 rs11648314 chr16:68596775 A/G cg02972257 chr16:68554789 NA -0.7 -8.17 -0.45 1.25e-14 Ulcerative colitis; CESC cis rs6460942 1.000 rs62448568 chr7:12407445 A/G cg10578991 chr7:12443926 VWDE -0.55 -5.84 -0.34 1.53e-8 Coronary artery disease; CESC cis rs2243480 1.000 rs316329 chr7:65608416 A/C cg13147721 chr7:65941812 NA -0.97 -8.88 -0.48 1.05e-16 Diabetic kidney disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25754926 chr6:7986689 MGC26597 0.43 6.06 0.35 4.74e-9 Fibrinogen levels; CESC trans rs875971 1.000 rs778685 chr7:65836176 G/T cg26939375 chr7:64535504 NA 0.47 6.06 0.35 4.66e-9 Aortic root size; CESC cis rs67311347 1.000 rs9834052 chr3:40399060 G/A cg09455208 chr3:40491958 NA 0.47 8.19 0.45 1.11e-14 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21701354 chr7:129592850 UBE2H 0.55 6.65 0.38 1.65e-10 Gut microbiome composition (summer); CESC cis rs644799 0.672 rs11021307 chr11:95501407 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.8 11.91 0.59 1.72e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7089973 0.549 rs34434610 chr10:116739745 A/G cg23260525 chr10:116636907 FAM160B1 0.3 5.24 0.31 3.21e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6662572 0.737 rs72677550 chr1:46589276 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.06 0.3 7.81e-7 Blood protein levels; CESC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg26338869 chr17:61819248 STRADA -0.7 -9.46 -0.5 1.75e-18 Prudent dietary pattern; CESC cis rs7829975 0.774 rs1039915 chr8:8679614 T/C cg15556689 chr8:8085844 FLJ10661 0.47 5.95 0.34 8.53e-9 Mood instability; CESC cis rs7635838 0.892 rs4684773 chr3:11418508 C/T cg00170343 chr3:11313890 ATG7 0.42 5.56 0.32 6.72e-8 HDL cholesterol; CESC cis rs10463316 0.832 rs246486 chr5:150727880 C/T cg03212797 chr5:150827313 SLC36A1 0.56 7.24 0.41 4.73e-12 Metabolite levels (Pyroglutamine); CESC cis rs4566357 0.576 rs3769644 chr2:227917240 C/G cg05526886 chr2:227700861 RHBDD1 -0.52 -6.83 -0.39 5.73e-11 Coronary artery disease; CESC cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg05347473 chr6:146136440 FBXO30 -0.53 -6.74 -0.38 9.76e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2066819 1.000 rs11575229 chr12:56750737 C/T cg26714650 chr12:56694279 CS -1.39 -9.05 -0.49 3.19e-17 Psoriasis vulgaris; CESC cis rs10256972 0.527 rs2949170 chr7:1216438 A/G cg07092213 chr7:1199455 ZFAND2A -0.42 -5.32 -0.31 2.21e-7 Longevity;Endometriosis; CESC cis rs8031584 0.918 rs3817498 chr15:31268781 T/C cg08704250 chr15:31115839 NA -0.54 -6.81 -0.39 6.41e-11 Huntington's disease progression; CESC cis rs929596 0.614 rs10929302 chr2:234665782 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.66 -8.28 -0.45 6.14e-15 Total bilirubin levels in HIV-1 infection; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10089324 chr1:51984752 EPS15 0.54 7.36 0.41 2.37e-12 Systemic lupus erythematosus; CESC cis rs1670533 0.932 rs13108207 chr4:1054218 C/T cg04106633 chr4:1044584 NA 0.39 5.1 0.3 6.45e-7 Recombination rate (females); CESC cis rs75477785 0.590 rs12566152 chr1:209986747 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.04 0.35 5.06e-9 Cleft lip with or without cleft palate; CESC trans rs9467711 0.606 rs13203358 chr6:26590578 A/T cg01620082 chr3:125678407 NA -0.62 -6.04 -0.35 5.11e-9 Autism spectrum disorder or schizophrenia; CESC cis rs11683229 0.777 rs2018650 chr2:63272724 T/C cg17519650 chr2:63277830 OTX1 -0.73 -5.76 -0.33 2.36e-8 Protein quantitative trait loci; CESC cis rs11252926 0.550 rs10904148 chr10:454551 G/T cg16386425 chr10:429943 DIP2C -0.57 -7.25 -0.41 4.54e-12 Psychosis in Alzheimer's disease; CESC cis rs5769765 0.908 rs2319464 chr22:50265777 A/G cg02269571 chr22:50332266 NA 0.46 6.25 0.36 1.62e-9 Schizophrenia; CESC cis rs1107366 1.000 rs1107366 chr3:125904165 A/G cg08481491 chr3:125900108 ALDH1L1 -0.37 -5.33 -0.31 2.14e-7 Metabolite levels; CESC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg09877947 chr5:131593287 PDLIM4 -0.41 -5.11 -0.3 6.2e-7 Acylcarnitine levels; CESC cis rs2952156 0.920 rs2517957 chr17:37838716 G/A cg07936489 chr17:37558343 FBXL20 -0.6 -7.77 -0.43 1.77e-13 Asthma; CESC cis rs870825 0.616 rs4416519 chr4:185639502 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC trans rs7944735 0.578 rs7949985 chr11:48062449 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.05 0.35 4.89e-9 Intraocular pressure; CESC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg05025164 chr4:1340916 KIAA1530 -0.83 -11.34 -0.57 1.48e-24 Longevity; CESC cis rs2635047 0.565 rs2571004 chr18:44710302 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.59 0.32 5.7e-8 Educational attainment; CESC cis rs1499614 0.901 rs2178742 chr7:66197799 G/A cg12463550 chr7:65579703 CRCP 0.73 5.73 0.33 2.78e-8 Gout; CESC cis rs2361718 0.500 rs12451697 chr17:78100690 T/A cg20811857 chr17:78079795 GAA -0.42 -6.04 -0.35 5.31e-9 Yeast infection; CESC cis rs1065852 0.526 rs2413663 chr22:42402399 T/A cg22189786 chr22:42395067 WBP2NL 0.43 5.34 0.31 2e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg11764359 chr7:65958608 NA 0.82 10.05 0.53 2.44e-20 Aortic root size; CESC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg18876405 chr7:65276391 NA -0.7 -9.74 -0.51 2.25e-19 Aortic root size; CESC cis rs11722228 0.521 rs12501336 chr4:10137351 G/A cg14348967 chr4:10160060 NA -0.4 -5.3 -0.31 2.43e-7 Gout;Urate levels;Serum uric acid levels; CESC cis rs2180341 0.751 rs9388553 chr6:127574044 A/G cg27446573 chr6:127587934 RNF146 0.87 12.25 0.6 1.19e-27 Breast cancer; CESC cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg05283184 chr6:79620031 NA -0.42 -6.43 -0.37 5.98e-10 Intelligence (multi-trait analysis); CESC cis rs1178968 1.000 rs4273741 chr7:72773966 C/A cg25889504 chr7:72793014 NA 0.47 5.03 0.3 8.91e-7 Triglyceride levels; CESC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg25783544 chr11:47291846 MADD 0.45 5.16 0.3 4.88e-7 Subjective well-being; CESC trans rs1814175 0.817 rs10769617 chr11:49810421 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -20.27 -0.78 8.26e-56 Height; CESC cis rs7084402 0.967 rs1649082 chr10:60292434 A/C cg07615347 chr10:60278583 BICC1 0.61 9.55 0.51 9.26e-19 Refractive error; CESC cis rs10751667 0.643 rs12278229 chr11:946985 A/G cg20946044 chr11:1010712 AP2A2 -0.39 -5.53 -0.32 7.73e-8 Alzheimer's disease (late onset); CESC trans rs12960505 0.506 rs6508235 chr18:51053941 A/G cg06077405 chr7:2313805 SNX8 -0.53 -7.04 -0.4 1.6e-11 Intelligence (multi-trait analysis); CESC cis rs1153858 1.000 rs12593230 chr15:45646968 A/T cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.45e-9 Homoarginine levels; CESC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg00684032 chr4:1343700 KIAA1530 0.41 5.83 0.34 1.58e-8 Obesity-related traits; CESC cis rs7937682 0.632 rs4936800 chr11:111734097 T/A cg09085632 chr11:111637200 PPP2R1B 0.91 11.76 0.59 5.82e-26 Primary sclerosing cholangitis; CESC cis rs11122272 0.701 rs2790887 chr1:231523724 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs7605827 0.866 rs11689153 chr2:15533899 A/G cg19274914 chr2:15703543 NA 0.35 6.39 0.37 7.22e-10 Educational attainment (years of education); CESC cis rs9486719 1.000 rs67996804 chr6:96884387 C/T cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs12325245 0.536 rs71389028 chr16:58663260 G/A cg02549819 chr16:58548995 SETD6 0.94 6.09 0.35 4.04e-9 Schizophrenia; CESC cis rs9359856 0.510 rs78649003 chr6:90454644 A/C cg13799429 chr6:90582589 CASP8AP2 -0.68 -7.68 -0.43 3.1400000000000003e-13 Bipolar disorder; CESC cis rs6964587 0.869 rs2013334 chr7:91549657 G/A cg01689657 chr7:91764605 CYP51A1 -0.29 -5.17 -0.3 4.57e-7 Breast cancer; CESC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg07507251 chr3:52567010 NT5DC2 0.43 7.4 0.41 1.83e-12 Bipolar disorder; CESC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg07507251 chr3:52567010 NT5DC2 0.4 6.99 0.39 2.26e-11 Bipolar disorder; CESC cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg12365402 chr11:9010492 NRIP3 0.33 5.24 0.31 3.23e-7 Hemoglobin concentration; CESC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg05863683 chr7:1912471 MAD1L1 -0.45 -6.67 -0.38 1.48e-10 Bipolar disorder and schizophrenia; CESC cis rs926938 0.618 rs360675 chr1:115490918 T/C cg12756093 chr1:115239321 AMPD1 0.5 7.16 0.4 7.75e-12 Autism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13155599 chr4:120221765 C4orf3 0.63 6.85 0.39 5.25e-11 Gut microbiome composition (summer); CESC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg12963246 chr6:28129442 ZNF389 0.48 5.23 0.31 3.49e-7 Depression; CESC cis rs6580649 0.657 rs57863747 chr12:48470425 G/T cg24011408 chr12:48396354 COL2A1 -0.4 -5.04 -0.3 8.67e-7 Lung cancer; CESC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg18404041 chr3:52824283 ITIH1 -0.4 -6.63 -0.38 1.85e-10 Bipolar disorder; CESC cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg08564027 chr20:61660810 NA 0.9 15.37 0.69 1.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs2353275 0.677 rs2353813 chr10:88276181 T/C cg07322936 chr10:88137208 NA 0.95 5.86 0.34 1.4e-8 Asthma (childhood onset);Asthma; CESC cis rs4253772 0.938 rs75977757 chr22:46641525 G/T cg18190219 chr22:46762943 CELSR1 -0.62 -5.89 -0.34 1.19e-8 LDL cholesterol;Cholesterol, total; CESC cis rs1153858 1.000 rs4775907 chr15:45638647 G/A cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs1570884 0.516 rs9526580 chr13:50164023 C/G cg08779649 chr13:50194554 NA -0.35 -6.1 -0.35 3.66e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs6963495 0.719 rs73190174 chr7:105161216 T/G cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg18446336 chr7:2847575 GNA12 -0.35 -5.56 -0.32 6.7e-8 Height; CESC cis rs5744897 0.708 rs34504371 chr12:133279469 G/A cg17341477 chr12:133246679 POLE 0.57 5.2 0.3 3.93e-7 Urate levels in overweight individuals; CESC cis rs6662572 0.737 rs10890357 chr1:46318054 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.04 -0.3 8.65e-7 Blood protein levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07835289 chr1:236030215 LYST 0.49 6.31 0.36 1.2e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7829975 0.593 rs2921051 chr8:8320104 C/A cg06636001 chr8:8085503 FLJ10661 0.51 6.75 0.38 9.33e-11 Mood instability; CESC cis rs6061231 0.561 rs67072353 chr20:60940702 G/A cg22633769 chr20:60982531 CABLES2 0.59 5.14 0.3 5.4e-7 Colorectal cancer; CESC cis rs2273669 0.667 rs11153150 chr6:109316652 C/G cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs7100689 0.784 rs7089058 chr10:82071263 T/C cg09936400 chr10:82049201 MAT1A 0.36 5.23 0.31 3.51e-7 Post bronchodilator FEV1; CESC cis rs9462846 0.959 rs6937172 chr6:42884375 A/T cg05552183 chr6:42928497 GNMT 0.46 5.25 0.31 3.08e-7 Blood protein levels; CESC cis rs9796 0.689 rs9888718 chr15:41446254 T/G cg09898695 chr15:41135793 SPINT1 -0.22 -5.05 -0.3 8.12e-7 Menopause (age at onset); CESC cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg13880726 chr7:1868755 MAD1L1 -0.48 -5.08 -0.3 7.23e-7 Bipolar disorder; CESC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg21963583 chr11:68658836 MRPL21 0.4 5.52 0.32 8.06e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7949030 0.688 rs2849031 chr11:62365665 G/A cg11742103 chr11:62369870 EML3;MTA2 -0.62 -9.32 -0.5 4.88e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs72848980 0.512 rs3781362 chr10:105375601 T/C cg00126946 chr10:105363258 SH3PXD2A 0.61 8.61 0.47 6.83e-16 White matter hyperintensity burden; CESC cis rs6964587 0.621 rs39744 chr7:92043016 A/G cg17063962 chr7:91808500 NA 0.51 7.42 0.41 1.55e-12 Breast cancer; CESC cis rs2000999 0.514 rs17604676 chr16:72221984 C/T cg04254540 chr16:71951199 KIAA0174 -0.58 -5.09 -0.3 6.93e-7 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC cis rs1045714 0.895 rs2293405 chr7:2644607 G/T cg20813462 chr7:2646259 IQCE 0.63 5.57 0.32 6.1e-8 Urate levels in lean individuals; CESC cis rs2075371 0.863 rs12707139 chr7:133954153 A/G cg11752832 chr7:134001865 SLC35B4 0.53 6.79 0.38 7.51e-11 Mean platelet volume; CESC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg04944784 chr2:26401820 FAM59B -0.67 -7.64 -0.42 3.95e-13 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23296058 chr5:86708877 CCNH 0.59 6.56 0.37 2.74e-10 Gut microbiome composition (summer); CESC cis rs11997175 0.583 rs67830367 chr8:33833788 G/C ch.8.33884649F chr8:33765107 NA 0.48 6.07 0.35 4.49e-9 Body mass index; CESC cis rs60843830 1.000 rs17714252 chr2:285471 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.78 10.2 0.53 8.1899999999999992e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs910316 1.000 rs910316 chr14:75626042 A/C cg08847533 chr14:75593920 NEK9 1.0 18.49 0.75 1.41e-49 Height; CESC cis rs734999 0.545 rs28568531 chr1:2555640 T/A cg20673091 chr1:2541236 MMEL1 0.47 7.67 0.43 3.2e-13 Ulcerative colitis; CESC cis rs80130819 0.515 rs7315258 chr12:48572670 T/C cg05342945 chr12:48394962 COL2A1 -0.54 -5.87 -0.34 1.3e-8 Prostate cancer; CESC cis rs7666738 0.611 rs34982650 chr4:98819530 T/A cg05340658 chr4:99064831 C4orf37 0.73 10.48 0.54 1.02e-21 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg01579765 chr21:45077557 HSF2BP -0.54 -9.03 -0.49 3.57e-17 Mean corpuscular volume; CESC cis rs9614461 0.702 rs16993867 chr22:45733199 A/G cg01808030 chr22:45809952 RIBC2;SMC1B 0.67 7.8 0.43 1.43e-13 Tonsillectomy; CESC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg21251018 chr6:28226885 NKAPL 0.34 5.12 0.3 5.83e-7 Depression; CESC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg23131131 chr22:24373011 LOC391322 0.68 9.67 0.51 3.75e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2832191 0.740 rs2012645 chr21:30445961 G/A cg08807101 chr21:30365312 RNF160 0.93 14.2 0.66 2.05e-34 Dental caries; CESC cis rs1003719 0.667 rs2835606 chr21:38490851 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 6.62 0.38 1.99e-10 Eye color traits; CESC cis rs2997447 0.706 rs17184898 chr1:26447870 A/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.17 0.3 4.68e-7 QRS complex (12-leadsum); CESC trans rs3780486 0.522 rs7029897 chr9:33124042 T/C cg04842962 chr6:43655489 MRPS18A 0.71 11.02 0.56 1.71e-23 IgG glycosylation; CESC cis rs4689388 0.610 rs4328980 chr4:6281756 A/G cg14416269 chr4:6271139 WFS1 0.43 6.1 0.35 3.66e-9 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2204008 0.605 rs4608149 chr12:38132057 G/C cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs8064299 0.967 rs7420 chr17:72765215 A/G cg25054828 chr17:72772726 NAT9;TMEM104 -0.6 -8.62 -0.47 6.11e-16 Monocyte count; CESC cis rs28647808 0.881 rs71483207 chr9:136258698 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.86 5.78 0.33 2.09e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17767659 chr6:41888922 MED20;BYSL 0.57 7.12 0.4 1e-11 Gut microbiome composition (summer); CESC cis rs2404602 0.684 rs3910756 chr15:76945369 C/T cg00316803 chr15:76480434 C15orf27 0.4 5.67 0.33 3.76e-8 Blood metabolite levels; CESC cis rs7208859 0.623 rs9897728 chr17:29108804 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12477438 0.520 rs720229 chr2:99704273 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.88 0.62 8.35e-30 Chronic sinus infection; CESC cis rs2991971 0.782 rs10789463 chr1:45927848 C/A cg05343316 chr1:45956843 TESK2 0.58 8.41 0.46 2.59e-15 High light scatter reticulocyte count; CESC cis rs10949834 0.878 rs2237501 chr7:73504359 A/G cg07137043 chr7:73588983 EIF4H -0.65 -5.65 -0.33 4.1e-8 Verbal memory performance (residualized delayed recall change); CESC trans rs9929218 1.000 rs2113201 chr16:68815000 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.64 -8.5 -0.46 1.38e-15 Colorectal cancer; CESC cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg06970220 chr1:156163860 SLC25A44 -0.42 -5.65 -0.33 4.15e-8 Testicular germ cell tumor; CESC cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg17366294 chr4:99064904 C4orf37 0.57 7.78 0.43 1.6e-13 Colonoscopy-negative controls vs population controls; CESC cis rs11650494 0.908 rs118099826 chr17:47447836 G/T cg08112188 chr17:47440006 ZNF652 1.16 7.85 0.43 1.03e-13 Prostate cancer; CESC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.71 -0.55 1.84e-22 Alzheimer's disease; CESC cis rs863345 0.967 rs10908679 chr1:158506275 T/G cg12129480 chr1:158549410 OR10X1 -0.31 -6.28 -0.36 1.4e-9 Pneumococcal bacteremia; CESC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg12963246 chr6:28129442 ZNF389 0.49 6.17 0.35 2.57e-9 Parkinson's disease; CESC cis rs34779708 0.966 rs4934539 chr10:35472199 A/G cg04310649 chr10:35416472 CREM -0.54 -6.78 -0.38 7.74e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs611744 0.538 rs59930666 chr8:109262296 T/C cg21045802 chr8:109455806 TTC35 0.56 7.02 0.4 1.89e-11 Dupuytren's disease; CESC cis rs12681366 0.537 rs3019284 chr8:95473076 A/C cg13257157 chr8:95487014 RAD54B 0.45 5.44 0.32 1.23e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7903847 0.642 rs11812223 chr10:99158455 T/C cg20016023 chr10:99160130 RRP12 -0.3 -5.17 -0.3 4.61e-7 Granulocyte percentage of myeloid white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03066081 chr17:77784036 NA -0.42 -6.09 -0.35 4e-9 Gambling; CESC cis rs919433 0.927 rs7592748 chr2:198170688 G/A cg03934865 chr2:198174659 NA -0.42 -5.55 -0.32 6.94e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg12718519 chr1:2058417 PRKCZ 0.25 5.06 0.3 8.01e-7 Height; CESC cis rs7772486 0.686 rs2092263 chr6:146029687 G/A cg23711669 chr6:146136114 FBXO30 -0.87 -12.9 -0.62 7e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs10924970 0.649 rs4659493 chr1:235482272 T/C cg26050004 chr1:235667680 B3GALNT2 0.44 5.11 0.3 6.16e-7 Asthma; CESC trans rs61931739 0.500 rs34703942 chr12:34583776 T/C cg26384229 chr12:38710491 ALG10B -0.53 -7.43 -0.42 1.46e-12 Morning vs. evening chronotype; CESC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs9911578 1.000 rs2079703 chr17:56603978 G/A cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.5e-11 Intelligence (multi-trait analysis); CESC cis rs9486719 0.790 rs2499790 chr6:96845078 G/A cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs17253792 0.822 rs79538158 chr14:56051365 G/T cg01858014 chr14:56050164 KTN1 -0.97 -7.15 -0.4 8.64e-12 Putamen volume; CESC cis rs7647973 0.580 rs4955432 chr3:49266772 C/T cg02487422 chr3:49467188 NICN1 0.4 5.49 0.32 9.35e-8 Menarche (age at onset); CESC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.49 0.42 1.01e-12 Prudent dietary pattern; CESC cis rs5498 0.809 rs1056538 chr19:10402938 G/A cg21994045 chr19:10403936 ICAM5 0.45 6.36 0.36 8.75e-10 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs155076 0.711 rs4770131 chr13:21897468 A/G cg23743428 chr13:21893420 NA -0.43 -5.17 -0.3 4.64e-7 White matter hyperintensity burden; CESC cis rs28386778 0.700 rs12449555 chr17:62003982 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.66 -8.79 -0.48 1.96e-16 Prudent dietary pattern; CESC cis rs6495122 0.662 rs12898997 chr15:75090349 C/T cg14664628 chr15:75095509 CSK -0.72 -9.91 -0.52 6.94e-20 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg21724239 chr8:58056113 NA 0.57 5.87 0.34 1.3e-8 Developmental language disorder (linguistic errors); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg06506598 chr5:79783889 FAM151B 0.47 6.34 0.36 1.01e-9 Thyroid stimulating hormone; CESC cis rs7772486 0.764 rs2265468 chr6:146218346 A/C cg23711669 chr6:146136114 FBXO30 0.94 13.79 0.65 5.83e-33 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25697769 chr22:39097335 JOSD1 0.52 6.05 0.35 5.03e-9 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs2162870 chr5:228129 G/A cg20965017 chr5:231967 SDHA -0.45 -5.08 -0.3 7.29e-7 Breast cancer; CESC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs11809207 0.523 rs2783626 chr1:26501044 C/T cg00147160 chr1:26503991 CNKSR1 -0.28 -5.36 -0.31 1.81e-7 Height; CESC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg07952391 chr2:88470173 THNSL2 -0.73 -10.83 -0.55 7.24e-23 Response to metformin (IC50); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15522353 chr1:39547558 MACF1 0.56 6.12 0.35 3.41e-9 Gut microbiome composition (summer); CESC cis rs965469 0.842 rs6051776 chr20:3332062 T/C cg25506879 chr20:3388711 C20orf194 -0.51 -5.45 -0.32 1.18e-7 IFN-related cytopenia; CESC cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg23711669 chr6:146136114 FBXO30 1.01 15.91 0.7 1.88e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs863345 0.564 rs10908662 chr1:158489200 C/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg11168104 chr5:1857477 NA -0.39 -5.8 -0.34 1.85e-8 Cardiovascular disease risk factors; CESC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.3 0.53 3.96e-21 Prudent dietary pattern; CESC cis rs4629180 0.630 rs10188189 chr2:102127926 A/G cg01388757 chr2:102091195 RFX8 -0.32 -5.26 -0.31 3.02e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs798554 0.616 rs1636252 chr7:2884993 A/C cg13628971 chr7:2884303 GNA12 0.47 6.27 0.36 1.46e-9 Height; CESC cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 6.1e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs10823500 0.777 rs10762348 chr10:71952322 C/A cg04118878 chr10:71993077 PPA1 0.46 5.47 0.32 1.02e-7 Blood protein levels; CESC cis rs2463822 0.925 rs2513075 chr11:62102408 C/T cg06239285 chr11:62104954 ASRGL1 0.89 8.97 0.48 5.69e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg17971929 chr21:40555470 PSMG1 1.07 16.63 0.71 4.99e-43 Cognitive function; CESC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg02475777 chr4:1388615 CRIPAK 0.73 9.3 0.5 5.53e-18 Longevity; CESC cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg12963246 chr6:28129442 ZNF389 0.57 7.78 0.43 1.65e-13 Depression; CESC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg00745463 chr17:30367425 LRRC37B 0.58 5.72 0.33 2.86e-8 Hip circumference adjusted for BMI; CESC cis rs2519796 0.564 rs2519111 chr9:136809118 C/G cg13751417 chr9:136814406 VAV2 -0.43 -5.55 -0.32 6.8e-8 Hematocrit;Hemoglobin concentration; CESC cis rs9486719 1.000 rs12197411 chr6:97039621 G/A cg18709589 chr6:96969512 KIAA0776 -0.5 -5.42 -0.32 1.31e-7 Migraine;Coronary artery disease; CESC cis rs7208859 0.673 rs2470251 chr17:29095061 T/C cg19761014 chr17:28927070 LRRC37B2 0.68 6.7 0.38 1.26e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg17366294 chr4:99064904 C4orf37 0.54 7.1 0.4 1.11e-11 Colonoscopy-negative controls vs population controls; CESC cis rs3105593 1.000 rs2630 chr15:50849399 T/C cg08437265 chr15:50716283 USP8 0.4 5.14 0.3 5.28e-7 QT interval; CESC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg27266027 chr21:40555129 PSMG1 0.42 5.07 0.3 7.6e-7 Cognitive function; CESC cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 2e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6580649 0.941 rs757556 chr12:48502493 C/T cg05342945 chr12:48394962 COL2A1 0.55 6.32 0.36 1.13e-9 Lung cancer; CESC cis rs365132 0.875 rs2940521 chr5:176339209 A/C cg16309518 chr5:176445507 NA -0.37 -5.37 -0.31 1.71e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs7274811 0.681 rs293733 chr20:31975976 C/T cg21523528 chr20:32077966 CBFA2T2 -0.46 -5.44 -0.32 1.23e-7 Height; CESC cis rs10791111 1 rs10791111 chr11:130856099 T/G cg12179176 chr11:130786555 SNX19 0.7 10.99 0.56 2.12e-23 Autism spectrum disorder or schizophrenia; CESC cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.87 7.42 0.41 1.64e-12 Initial pursuit acceleration; CESC cis rs9611565 0.722 rs202635 chr22:41809637 C/T cg06634786 chr22:41940651 POLR3H 0.71 7.47 0.42 1.16e-12 Vitiligo; CESC cis rs60871478 0.853 rs62432864 chr7:808405 T/G cg27478167 chr7:817139 HEATR2 -0.5 -5.6 -0.33 5.36e-8 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26551211 chr6:170599713 DLL1 0.54 6.09 0.35 4.01e-9 Gut microbiome composition (summer); CESC cis rs7084402 0.967 rs1658479 chr10:60289398 C/A cg07615347 chr10:60278583 BICC1 0.61 9.68 0.51 3.68e-19 Refractive error; CESC cis rs11645898 0.935 rs4788611 chr16:72175256 A/G cg14768367 chr16:72042858 DHODH -0.76 -6.49 -0.37 4.28e-10 Blood protein levels; CESC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg23131131 chr22:24373011 LOC391322 -0.56 -7.41 -0.41 1.64e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4561483 0.673 rs28279 chr16:11968555 A/C cg08843971 chr16:11963173 GSPT1 0.53 7.75 0.43 1.95e-13 Testicular germ cell tumor; CESC cis rs6542838 0.641 rs6741166 chr2:99534926 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -5.84 -0.34 1.55e-8 Fear of minor pain; CESC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg26677194 chr12:130822605 PIWIL1 -0.39 -5.39 -0.31 1.58e-7 Menopause (age at onset); CESC cis rs9814567 1.000 rs9854299 chr3:134206728 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -6.08 -0.35 4.26e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs546131 0.928 rs499183 chr11:34836678 A/G cg11058730 chr11:34937778 PDHX;APIP 0.48 5.98 0.34 7.09e-9 Lung disease severity in cystic fibrosis; CESC cis rs2273669 0.667 rs12214121 chr6:109322554 A/G cg05315195 chr6:109294784 ARMC2 0.67 6.23 0.36 1.84e-9 Prostate cancer; CESC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg13206674 chr6:150067644 NUP43 0.43 6.17 0.35 2.52e-9 Lung cancer; CESC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.73 9.48 0.5 1.54e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11785400 0.793 rs7007891 chr8:143749228 C/T cg24634471 chr8:143751801 JRK -0.45 -5.62 -0.33 4.94e-8 Schizophrenia; CESC trans rs2099077 0.867 rs1864084 chr5:102791137 T/A cg07434438 chr16:72961899 ZFHX3 0.5 6.78 0.38 7.88e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2050392 0.858 rs306583 chr10:30710057 C/T cg18806716 chr10:30721971 MAP3K8 0.41 6.07 0.35 4.53e-9 Inflammatory bowel disease; CESC cis rs6448317 0.906 rs6448313 chr4:24905088 G/A cg21108841 chr4:24914750 CCDC149 0.49 6.15 0.35 2.9e-9 Heschl's gyrus morphology; CESC cis rs7429990 0.965 rs4858810 chr3:48043737 G/A cg11946769 chr3:48343235 NME6 -0.49 -6.01 -0.35 6.15e-9 Educational attainment (years of education); CESC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.564 rs313804 chr7:65514622 A/G cg26939375 chr7:64535504 NA 0.48 6.19 0.36 2.32e-9 Aortic root size; CESC cis rs447735 0.587 rs7188458 chr16:89726484 A/G cg03605463 chr16:89740564 NA 0.41 5.22 0.31 3.68e-7 Hemoglobin concentration; CESC cis rs8017423 0.967 rs6575117 chr14:90715412 G/A cg14092571 chr14:90743983 NA -0.58 -8.73 -0.47 2.91e-16 Mortality in heart failure; CESC cis rs9858542 0.953 rs7633271 chr3:49555963 T/C cg03060546 chr3:49711283 APEH -0.5 -5.79 -0.33 2.02e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2712381 0.517 rs62273237 chr3:128310107 T/C cg16766828 chr3:128327626 NA -0.32 -5.47 -0.32 1.05e-7 Monocyte count; CESC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg10691866 chr7:65817282 TPST1 0.32 5.5 0.32 9.11e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03520966 chr10:90751269 ACTA2;FAS 0.54 6.34 0.36 9.7e-10 Gut microbiome composition (summer); CESC cis rs9733 0.744 rs11204725 chr1:150742700 T/C cg18016565 chr1:150552671 MCL1 -0.36 -5.82 -0.34 1.71e-8 Tonsillectomy; CESC cis rs9467711 0.659 rs35304979 chr6:26356347 C/A cg12826209 chr6:26865740 GUSBL1 0.61 5.17 0.3 4.52e-7 Autism spectrum disorder or schizophrenia; CESC cis rs524281 1.000 rs524281 chr11:65886662 C/A cg14036092 chr11:66035641 RAB1B 0.55 6.42 0.37 6.29e-10 Electroencephalogram traits; CESC cis rs4233802 1.000 rs10209398 chr2:151151095 A/G cg25300694 chr2:151184358 NA -1.04 -8.8 -0.48 1.75e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs2760061 0.598 rs590657 chr1:228117581 A/C cg02753203 chr1:228287806 NA -0.5 -7.24 -0.41 4.85e-12 Diastolic blood pressure; CESC cis rs4642101 0.855 rs9873475 chr3:12845422 A/G cg05775895 chr3:12838266 CAND2 0.39 5.78 0.33 2.1e-8 QRS complex (12-leadsum); CESC cis rs116095464 0.558 rs10055405 chr5:265666 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.41 0.32 1.42e-7 Breast cancer; CESC cis rs734999 0.588 rs2985859 chr1:2532416 T/C cg20673091 chr1:2541236 MMEL1 -0.45 -7.46 -0.42 1.2e-12 Ulcerative colitis; CESC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.99 0.39 2.19e-11 Bipolar disorder; CESC cis rs2274273 0.624 rs66551709 chr14:55791022 A/T cg04306507 chr14:55594613 LGALS3 0.29 5.08 0.3 7.1e-7 Protein biomarker; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19552494 chr11:60674271 PRPF19 0.53 6.83 0.39 5.71e-11 Gut microbiota (bacterial taxa); CESC cis rs6121246 0.567 rs6060247 chr20:30190720 C/G cg13852791 chr20:30311386 BCL2L1 0.58 5.44 0.32 1.2e-7 Mean corpuscular hemoglobin; CESC cis rs1707322 1.000 rs4660896 chr1:46372416 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg17366294 chr4:99064904 C4orf37 0.61 8.67 0.47 4.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs11122272 0.735 rs2572249 chr1:231514829 G/A cg06096015 chr1:231504339 EGLN1 0.42 6.11 0.35 3.53e-9 Hemoglobin concentration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02471486 chr8:71016278 NA 0.45 6.28 0.36 1.36e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs644799 0.965 rs566877 chr11:95528045 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7772486 0.875 rs13198450 chr6:146370524 C/A cg05347473 chr6:146136440 FBXO30 0.5 6.5 0.37 3.88e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg05368731 chr17:41323189 NBR1 -0.59 -7.79 -0.43 1.51e-13 Menopause (age at onset); CESC cis rs17384381 1.000 rs12758237 chr1:85870783 G/A cg16011679 chr1:85725395 C1orf52 0.8 8.1 0.45 1.98e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs2963155 0.518 rs853176 chr5:142636456 A/G cg17617527 chr5:142782415 NR3C1 -0.84 -8.0 -0.44 3.82e-14 Breast cancer; CESC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg09323728 chr8:95962352 TP53INP1 -0.39 -8.53 -0.46 1.11e-15 Type 2 diabetes; CESC cis rs372883 0.600 rs407712 chr21:30722531 G/A cg08807101 chr21:30365312 RNF160 -0.47 -5.44 -0.32 1.22e-7 Pancreatic cancer; CESC cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg22823121 chr1:150693482 HORMAD1 -0.4 -6.24 -0.36 1.69e-9 Tonsillectomy; CESC cis rs2276314 0.857 rs28375959 chr18:33601534 T/G cg19628046 chr18:33552617 C18orf21 0.51 5.58 0.32 5.92e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.67 -0.33 3.76e-8 Aortic root size; CESC cis rs7216064 1.000 rs4790908 chr17:65852907 T/G cg12091567 chr17:66097778 LOC651250 -0.8 -9.02 -0.48 3.83e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11203032 0.831 rs10887926 chr10:90940358 G/A cg16672925 chr10:90967113 CH25H 0.72 7.17 0.4 7.66e-12 Heart failure; CESC cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg01579765 chr21:45077557 HSF2BP -0.52 -9.28 -0.5 6.25e-18 Mean corpuscular volume; CESC trans rs208515 0.525 rs12191500 chr6:66668681 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 10.74 0.55 1.42e-22 Exhaled nitric oxide levels; CESC cis rs7894051 1.000 rs11101721 chr10:135190358 C/G cg24905316 chr10:135186343 ECHS1 0.64 5.59 0.32 5.6e-8 Lifespan; CESC cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg14784868 chr12:69753453 YEATS4 0.83 13.07 0.63 1.82e-30 Blood protein levels; CESC cis rs11122272 0.735 rs2749706 chr1:231527170 C/A cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.79e-9 Hemoglobin concentration; CESC cis rs9911578 0.835 rs9303398 chr17:56484257 T/C cg12560992 chr17:57184187 TRIM37 -0.87 -14.46 -0.66 2.55e-35 Intelligence (multi-trait analysis); CESC trans rs4596713 0.508 rs13289984 chr9:71775047 A/C cg16512924 chr15:28394682 HERC2 0.48 6.14 0.35 2.95e-9 Headache; CESC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg21963583 chr11:68658836 MRPL21 0.42 5.69 0.33 3.44e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs910316 1.000 rs11845639 chr14:75570293 C/T cg08847533 chr14:75593920 NEK9 0.98 18.45 0.75 1.85e-49 Height; CESC cis rs3540 0.533 rs2256110 chr15:90971036 T/C cg22089800 chr15:90895588 ZNF774 0.64 8.78 0.47 2.09e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs379440 0.686 rs163622 chr5:111793954 C/T cg14395298 chr13:23412250 NA 0.71 6.07 0.35 4.41e-9 vWF and FVIII levels; CESC cis rs1385374 1.000 rs1385374 chr12:129300694 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 0.61 5.3 0.31 2.42e-7 Systemic lupus erythematosus; CESC cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg03433033 chr1:76189801 ACADM 0.68 8.14 0.45 1.54e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg06074448 chr4:187884817 NA -0.37 -5.43 -0.32 1.3e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs3008870 0.583 rs2031495 chr1:67421714 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.99 11.11 0.56 8.58e-24 Lymphocyte percentage of white cells; CESC cis rs7208859 0.623 rs11652533 chr17:29060601 A/C cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.64 8.08 0.44 2.36e-14 Age-related macular degeneration (geographic atrophy); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23024824 chr15:70349890 TLE3 0.49 6.32 0.36 1.11e-9 Fibrinogen levels; CESC trans rs4716602 0.596 rs4997808 chr7:156158734 C/G cg07175507 chr18:77160758 NFATC1 -0.46 -6.2 -0.36 2.14e-9 Anti-saccade response; CESC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg08888203 chr3:10149979 C3orf24 0.51 6.39 0.37 7.29e-10 Alzheimer's disease; CESC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg11764359 chr7:65958608 NA 0.96 15.25 0.68 3.95e-38 Aortic root size; CESC cis rs9488822 0.676 rs868943 chr6:116337503 G/A cg15226275 chr6:116381976 FRK 0.24 6.2 0.36 2.17e-9 Cholesterol, total;LDL cholesterol; CESC cis rs2841277 0.676 rs10438246 chr14:105410183 T/C cg21017887 chr14:105400489 NA 0.42 6.83 0.39 5.93e-11 Rheumatoid arthritis; CESC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg13206674 chr6:150067644 NUP43 0.41 5.8 0.34 1.9e-8 Lung cancer; CESC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg02462569 chr6:150064036 NUP43 -0.35 -5.17 -0.3 4.52e-7 Lung cancer; CESC cis rs1465370 0.682 rs2268382 chr7:130027037 A/C cg04743876 chr7:130013617 NA 0.31 5.73 0.33 2.7e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -5.21 -0.3 3.78e-7 Developmental language disorder (linguistic errors); CESC cis rs4803468 0.905 rs284662 chr19:41932275 T/C cg14132834 chr19:41945861 ATP5SL -0.69 -8.39 -0.46 2.98e-15 Height; CESC cis rs9399137 0.507 rs4594969 chr6:135285586 A/T cg24558204 chr6:135376177 HBS1L 0.7 9.62 0.51 5.64e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05450629 chr15:90627448 IDH2 0.48 6.8 0.39 6.92e-11 Fibrinogen levels; CESC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.48 0.32 9.67e-8 Bipolar disorder; CESC cis rs2019216 0.542 rs7405615 chr17:21935430 C/G cg22648282 chr17:21454238 C17orf51 -0.39 -5.07 -0.3 7.48e-7 Pelvic organ prolapse; CESC cis rs17001868 0.568 rs74424549 chr22:40736938 A/C cg07138101 chr22:40742427 ADSL 0.57 5.38 0.31 1.66e-7 Mammographic density (dense area); CESC cis rs9796 0.553 rs1869908 chr15:41257224 C/A cg18705301 chr15:41695430 NDUFAF1 0.56 7.7 0.43 2.65e-13 Menopause (age at onset); CESC cis rs8114671 0.967 rs1577924 chr20:33784288 C/G cg06115741 chr20:33292138 TP53INP2 -0.41 -5.08 -0.3 7.22e-7 Height; CESC cis rs6496667 0.557 rs2601203 chr15:90958129 T/G cg10434728 chr15:90938212 IQGAP1 0.36 6.36 0.36 8.95e-10 Rheumatoid arthritis; CESC cis rs7772486 0.686 rs702314 chr6:146003510 G/A cg23711669 chr6:146136114 FBXO30 -0.86 -12.74 -0.62 2.59e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs965469 1.000 rs6037590 chr20:3374085 G/A cg25506879 chr20:3388711 C20orf194 -0.58 -6.11 -0.35 3.57e-9 IFN-related cytopenia; CESC trans rs11098499 0.615 rs28850368 chr4:120554313 G/A cg25214090 chr10:38739885 LOC399744 0.61 8.57 0.47 8.89e-16 Corneal astigmatism; CESC trans rs2727020 0.729 rs1164685 chr11:49293660 G/A cg15704280 chr7:45808275 SEPT13 0.87 14.55 0.67 1.22e-35 Coronary artery disease; CESC cis rs7246657 0.943 rs10420722 chr19:37973774 C/G cg23950597 chr19:37808831 NA -0.65 -6.67 -0.38 1.5e-10 Coronary artery calcification; CESC cis rs9291683 0.588 rs12506364 chr4:10023448 C/T cg00071950 chr4:10020882 SLC2A9 0.89 17.27 0.73 2.76e-45 Bone mineral density; CESC cis rs6964587 1.000 rs6952389 chr7:91657994 A/G cg17063962 chr7:91808500 NA 0.57 7.88 0.44 8.76e-14 Breast cancer; CESC cis rs7772486 0.875 rs2814873 chr6:146308932 T/C cg23711669 chr6:146136114 FBXO30 0.9 13.1 0.63 1.45e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg22105103 chr4:187893119 NA -0.49 -7.18 -0.4 7.25e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2276314 0.857 rs4799408 chr18:33588982 C/T cg19628046 chr18:33552617 C18orf21 -0.49 -5.57 -0.32 6.31e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs2066819 1.000 rs118130855 chr12:56677979 T/A cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs4808199 0.948 rs1859287 chr19:19422187 T/C cg03709012 chr19:19516395 GATAD2A 1.04 12.12 0.6 3.38e-27 Nonalcoholic fatty liver disease; CESC cis rs6541297 1.000 rs6665367 chr1:230279169 G/A cg20703242 chr1:230279135 GALNT2 0.68 10.87 0.56 5.47e-23 Coronary artery disease; CESC cis rs7520050 0.778 rs2991985 chr1:46080530 T/C cg24296786 chr1:45957014 TESK2 0.47 6.02 0.35 5.84e-9 Red blood cell count;Reticulocyte count; CESC cis rs4523957 0.620 rs9894215 chr17:2070698 G/A cg16513277 chr17:2031491 SMG6 -0.79 -11.85 -0.59 2.89e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.02 0.52 2.94e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14819942 chr15:35414228 NA -0.56 -6.6 -0.38 2.17e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6968419 0.755 rs4710 chr7:115897392 G/C cg02561103 chr7:115862891 TES -0.41 -5.33 -0.31 2.13e-7 Intraocular pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17165990 chr19:19656778 CILP2 -0.6 -6.83 -0.39 5.75e-11 Gut microbiome composition (summer); CESC cis rs5167 0.525 rs10402642 chr19:45453878 G/A cg09555818 chr19:45449301 APOC2 0.41 6.54 0.37 3.08e-10 Blood protein levels; CESC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg07167872 chr1:205819463 PM20D1 0.75 12.35 0.6 5.62e-28 Menarche (age at onset); CESC cis rs1465370 0.720 rs5011387 chr7:130017149 C/T cg04743876 chr7:130013617 NA 0.31 5.86 0.34 1.38e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC trans rs877282 0.891 rs11253393 chr10:788824 G/T cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24844295 chr17:78821928 RPTOR -0.6 -6.97 -0.39 2.5e-11 Gut microbiome composition (summer); CESC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg25783544 chr11:47291846 MADD 0.45 5.16 0.3 4.88e-7 Subjective well-being; CESC cis rs10883723 0.810 rs3740406 chr10:104272789 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.58 0.42 5.73e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs1278769 0.786 rs7998551 chr13:113540649 G/T cg00823993 chr13:113535758 ATP11A 0.58 7.56 0.42 6.46e-13 Interstitial lung disease; CESC cis rs11630290 1.000 rs72750990 chr15:64005333 C/T cg12036633 chr15:63758958 NA -0.56 -5.24 -0.31 3.26e-7 Iris characteristics; CESC cis rs3820928 0.874 rs2276593 chr2:227898434 A/G cg05526886 chr2:227700861 RHBDD1 0.46 5.84 0.34 1.51e-8 Pulmonary function; CESC cis rs708547 0.957 rs1623306 chr4:57773595 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -5.28 -0.31 2.67e-7 Response to bleomycin (chromatid breaks); CESC cis rs888194 0.677 rs7973253 chr12:109878115 A/G cg19025524 chr12:109796872 NA -0.41 -6.24 -0.36 1.73e-9 Neuroticism; CESC cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC cis rs6032067 0.641 rs17332243 chr20:43756071 T/C cg10761708 chr20:43804764 PI3 0.5 5.25 0.31 3.12e-7 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13614812 chr17:21254058 NA -0.45 -6.1 -0.35 3.81e-9 Gut microbiome composition (summer); CESC cis rs6087771 0.781 rs6089067 chr20:30358894 G/C cg13852791 chr20:30311386 BCL2L1 0.82 10.58 0.54 4.72e-22 Subcortical brain region volumes;Putamen volume; CESC cis rs34779708 0.931 rs4934697 chr10:35287192 C/T cg03585969 chr10:35415529 CREM 0.77 10.22 0.53 6.85e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs9303280 0.806 rs11870965 chr17:38030205 T/A cg19468946 chr17:37922297 IKZF3 -0.41 -5.45 -0.32 1.16e-7 Self-reported allergy; CESC cis rs11809207 0.523 rs7087 chr1:26496651 T/C cg00147160 chr1:26503991 CNKSR1 0.28 5.32 0.31 2.23e-7 Height; CESC cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg21138405 chr5:131827807 IRF1 -0.58 -9.83 -0.52 1.19e-19 Asthma (sex interaction); CESC cis rs2795502 1.000 rs2473119 chr10:43339038 A/T cg20628663 chr10:43360327 NA -0.63 -7.47 -0.42 1.16e-12 Blood protein levels; CESC cis rs6460942 0.597 rs17545416 chr7:12525944 A/T cg06484146 chr7:12443880 VWDE -0.71 -7.69 -0.43 2.88e-13 Coronary artery disease; CESC cis rs6066835 1.000 rs6063311 chr20:47325315 C/T cg18078177 chr20:47281410 PREX1 0.72 5.1 0.3 6.38e-7 Multiple myeloma; CESC cis rs9929218 0.906 rs10852450 chr16:68749529 G/A cg02972257 chr16:68554789 NA 0.57 6.59 0.38 2.32e-10 Colorectal cancer; CESC cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg03467027 chr4:99064603 C4orf37 0.45 5.67 0.33 3.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg18876405 chr7:65276391 NA -0.5 -6.98 -0.39 2.32e-11 Aortic root size; CESC cis rs7267979 0.966 rs4813557 chr20:25292545 C/T cg08601574 chr20:25228251 PYGB -0.39 -5.58 -0.32 6.07e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7772486 0.776 rs2265467 chr6:146218339 T/A cg23711669 chr6:146136114 FBXO30 0.77 10.91 0.56 3.81e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs4242434 0.819 rs6558173 chr8:22492103 A/C cg03733263 chr8:22462867 KIAA1967 -0.88 -15.25 -0.68 4.12e-38 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11922607 chr18:21083993 C18orf8 -0.61 -7.09 -0.4 1.24e-11 Gut microbiome composition (summer); CESC cis rs6062302 0.522 rs6090475 chr20:62245397 C/A cg06363034 chr20:62225388 GMEB2 -0.5 -6.35 -0.36 9.49e-10 Glioblastoma; CESC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg01988459 chr11:68622903 NA -0.42 -5.9 -0.34 1.12e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7665939 1.000 rs72727639 chr4:190107992 G/C cg14840187 chr4:190284988 NA -0.83 -6.89 -0.39 3.99e-11 Amyotrophic lateral sclerosis; CESC cis rs72945132 0.882 rs113472486 chr11:70194945 C/G cg14191688 chr11:70257035 CTTN 0.41 5.13 0.3 5.6e-7 Coronary artery disease; CESC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg16680214 chr1:154839983 KCNN3 -0.5 -7.57 -0.42 6.23e-13 Prostate cancer; CESC cis rs870825 0.587 rs28454955 chr4:185632701 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.89 0.39 3.95e-11 Blood protein levels; CESC trans rs61931739 0.500 rs7965679 chr12:34542494 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.74e-12 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00021576 chr1:244211966 NA 0.61 7.06 0.4 1.44e-11 Gut microbiome composition (summer); CESC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg10691866 chr7:65817282 TPST1 -0.34 -5.47 -0.32 1.06e-7 Aortic root size; CESC cis rs6570726 0.935 rs409725 chr6:145840340 G/A cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.36e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs11969893 0.649 rs12527901 chr6:101280435 G/A cg12253828 chr6:101329408 ASCC3 0.93 8.18 0.45 1.16e-14 Economic and political preferences (immigration/crime); CESC cis rs7267979 0.903 rs2500400 chr20:25354705 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -17.58 -0.73 2.19e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs17666538 0.535 rs1669613 chr8:617565 G/C cg07234876 chr8:600039 NA 0.84 5.94 0.34 9.04e-9 IgG glycosylation; CESC cis rs10504229 0.906 rs2270608 chr8:58194688 T/C cg02725872 chr8:58115012 NA -0.35 -5.17 -0.3 4.69e-7 Developmental language disorder (linguistic errors); CESC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg24881330 chr22:46731750 TRMU 0.8 6.6 0.38 2.24e-10 LDL cholesterol;Cholesterol, total; CESC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg24675658 chr1:53192096 ZYG11B -0.47 -5.92 -0.34 1.02e-8 Monocyte count; CESC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg16049864 chr8:95962084 TP53INP1 -0.66 -11.64 -0.58 1.46e-25 Type 2 diabetes; CESC cis rs5758659 0.657 rs5758587 chr22:42517636 C/G cg04733989 chr22:42467013 NAGA -0.43 -6.05 -0.35 4.98e-9 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26987697 chr4:47916498 NFXL1 0.54 6.24 0.36 1.68e-9 Gut microbiome composition (summer); CESC cis rs911555 0.723 rs7144010 chr14:103869869 G/A cg12935359 chr14:103987150 CKB 0.6 8.79 0.48 1.9e-16 Intelligence (multi-trait analysis); CESC cis rs887829 0.507 rs10929301 chr2:234663649 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -6.12 -0.35 3.35e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg06212747 chr3:49208901 KLHDC8B -0.46 -6.18 -0.35 2.45e-9 Resting heart rate; CESC cis rs7107174 1.000 rs2510054 chr11:77959659 A/G cg02023728 chr11:77925099 USP35 -0.43 -6.0 -0.35 6.56e-9 Testicular germ cell tumor; CESC cis rs66887589 0.967 rs13104219 chr4:120438174 G/T cg09307838 chr4:120376055 NA 0.51 6.78 0.38 7.71e-11 Diastolic blood pressure; CESC cis rs367615 0.552 rs2963023 chr5:108730070 C/T cg17395555 chr5:108820864 NA -0.45 -7.51 -0.42 8.87e-13 Colorectal cancer (SNP x SNP interaction); CESC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.83 0.34 1.59e-8 Bipolar disorder; CESC cis rs5769765 0.720 rs138820 chr22:50164078 A/G cg02269571 chr22:50332266 NA -0.45 -5.62 -0.33 4.82e-8 Schizophrenia; CESC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg17372223 chr3:52568218 NT5DC2 0.43 6.56 0.37 2.76e-10 Bipolar disorder; CESC cis rs9467773 0.620 rs9467810 chr6:26608261 A/C cg11502198 chr6:26597334 ABT1 0.49 7.03 0.4 1.79e-11 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16484018 chr1:33502708 AK2 -0.65 -7.72 -0.43 2.33e-13 Gut microbiome composition (summer); CESC cis rs11690935 0.877 rs13024846 chr2:172835803 C/T cg13550731 chr2:172543902 DYNC1I2 -0.92 -13.04 -0.63 2.35e-30 Schizophrenia; CESC cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg05283184 chr6:79620031 NA -0.44 -6.64 -0.38 1.74e-10 Intelligence (multi-trait analysis); CESC cis rs6499255 0.951 rs12595878 chr16:69628217 C/T cg15192750 chr16:69999425 NA 0.51 5.98 0.34 7.11e-9 IgE levels; CESC cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg22029157 chr1:209979665 IRF6 0.7 7.88 0.44 8.64e-14 Cleft lip with or without cleft palate; CESC cis rs17655565 0.543 rs1882122 chr12:52745616 G/A cg00777198 chr12:52828273 KRT75 0.37 5.11 0.3 6.04e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg11764359 chr7:65958608 NA 0.81 11.87 0.59 2.48e-26 Aortic root size; CESC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg09365446 chr1:150670422 GOLPH3L 0.41 5.73 0.33 2.74e-8 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00319449 chr10:77169139 NA 0.51 6.03 0.35 5.48e-9 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06831761 chr7:104885108 SRPK2 -0.46 -6.3 -0.36 1.26e-9 Gut microbiota (bacterial taxa); CESC cis rs66573146 0.831 rs67702333 chr4:6983040 C/G cg00086871 chr4:6988644 TBC1D14 1.21 7.9 0.44 7.68e-14 Granulocyte percentage of myeloid white cells; CESC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.99 10.24 0.53 5.84e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg13647721 chr17:30228624 UTP6 0.6 5.45 0.32 1.17e-7 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04005938 chr7:148334417 NA -0.72 -8.14 -0.45 1.54e-14 Gut microbiome composition (summer); CESC cis rs17253792 0.731 rs3736876 chr14:56120178 T/C cg01858014 chr14:56050164 KTN1 -0.96 -7.52 -0.42 8.3e-13 Putamen volume; CESC cis rs1348850 0.526 rs4893829 chr2:178399810 A/G cg22681709 chr2:178499509 PDE11A 0.49 5.28 0.31 2.73e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs977987 0.843 rs11149820 chr16:75422760 G/A cg03315344 chr16:75512273 CHST6 0.4 5.73 0.33 2.68e-8 Dupuytren's disease; CESC cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.05 0.3 8.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.547 rs8069811 chr17:17922280 G/A cg04398451 chr17:18023971 MYO15A -0.7 -10.37 -0.54 2.28e-21 Total body bone mineral density; CESC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03576123 chr11:487126 PTDSS2 -1.06 -10.99 -0.56 2.1e-23 Body mass index; CESC cis rs9486715 0.867 rs9384628 chr6:96960232 T/C cg18709589 chr6:96969512 KIAA0776 0.46 6.48 0.37 4.41e-10 Headache; CESC cis rs67460515 0.892 rs34896809 chr3:161059804 C/T cg03342759 chr3:160939853 NMD3 -0.54 -7.83 -0.43 1.17e-13 Parkinson's disease; CESC cis rs7264396 0.635 rs6058378 chr20:34546658 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.06 -0.56 1.23e-23 Total cholesterol levels; CESC cis rs6088580 0.634 rs4142007 chr20:32990050 G/T cg08999081 chr20:33150536 PIGU -0.64 -11.24 -0.57 3.23e-24 Glomerular filtration rate (creatinine); CESC cis rs3015497 0.528 rs3015467 chr14:51158848 C/T cg26011998 chr14:51135199 SAV1 -0.54 -5.84 -0.34 1.54e-8 Mean platelet volume; CESC cis rs9388451 0.872 rs2008027 chr6:126052359 A/G cg10911889 chr6:126070802 HEY2 0.36 5.1 0.3 6.59e-7 Brugada syndrome; CESC cis rs10838687 0.736 rs830083 chr11:47254051 G/C cg25783544 chr11:47291846 MADD -0.56 -6.45 -0.37 5.15e-10 Proinsulin levels; CESC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg07090678 chr1:91966139 CDC7 0.4 5.5 0.32 8.91e-8 Breast cancer; CESC cis rs3762637 0.943 rs28403550 chr3:122251838 C/A cg24169773 chr3:122142474 KPNA1 -0.59 -6.91 -0.39 3.59e-11 LDL cholesterol levels; CESC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg27535305 chr1:53392650 SCP2 0.34 5.89 0.34 1.17e-8 Monocyte count; CESC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg22105103 chr4:187893119 NA 0.48 6.79 0.38 7.4e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7957197 0.671 rs56158042 chr12:121455589 G/A cg02403541 chr12:121454288 C12orf43 -0.42 -5.05 -0.3 8.4e-7 Type 2 diabetes; CESC cis rs4604732 0.631 rs11490200 chr1:247625915 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7818688 1.000 rs11776189 chr8:96036741 T/G cg16049864 chr8:95962084 TP53INP1 0.61 5.76 0.33 2.28e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs8044868 0.586 rs6499557 chr16:72082654 A/G cg16558253 chr16:72132732 DHX38 -0.4 -6.32 -0.36 1.12e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72387598 1 rs72387598 chr1:45922977 CAT/C cg24296786 chr1:45957014 TESK2 -0.46 -5.15 -0.3 5.16e-7 Platelet distribution width; CESC cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg12927641 chr6:109611667 NA 0.45 6.99 0.39 2.17e-11 Reticulocyte fraction of red cells; CESC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg08888203 chr3:10149979 C3orf24 0.48 6.0 0.35 6.52e-9 Alzheimer's disease; CESC cis rs7216064 1.000 rs2046323 chr17:65849927 T/G cg07042672 chr17:66097459 LOC651250 -0.53 -5.57 -0.32 6.1e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs734999 0.549 rs6670198 chr1:2520527 T/C cg18854424 chr1:2615690 NA 0.29 5.58 0.32 5.79e-8 Ulcerative colitis; CESC cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.73 10.82 0.55 7.85e-23 Monocyte percentage of white cells; CESC cis rs727563 0.594 rs5758408 chr22:42077737 A/C cg03806693 chr22:41940476 POLR3H 1.09 12.68 0.61 4.09e-29 Crohn's disease;Inflammatory bowel disease; CESC cis rs8114671 0.836 rs2425012 chr20:33581955 G/A cg07148914 chr20:33460835 GGT7 -0.41 -5.28 -0.31 2.75e-7 Height; CESC cis rs7561273 0.586 rs11892283 chr2:24317850 T/C cg06627628 chr2:24431161 ITSN2 -0.48 -5.71 -0.33 3.03e-8 Quantitative traits; CESC cis rs5760092 0.755 rs4585126 chr22:24270005 T/C cg11905131 chr22:24372483 LOC391322 0.6 7.59 0.42 5.6e-13 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg09509183 chr1:209979624 IRF6 0.51 6.22 0.36 1.95e-9 Cleft lip with or without cleft palate; CESC cis rs947211 0.948 rs1775143 chr1:205755550 C/T cg14893161 chr1:205819251 PM20D1 0.4 5.23 0.31 3.42e-7 Parkinson's disease; CESC cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7845219 0.544 rs7015841 chr8:95920193 A/C cg13393036 chr8:95962371 TP53INP1 -0.42 -8.03 -0.44 3.25e-14 Type 2 diabetes; CESC cis rs6733011 0.508 rs925887 chr2:99514671 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.41 5.19 0.3 4.1e-7 Bipolar disorder; CESC cis rs8070128 0.583 rs7406982 chr17:17942613 C/T cg04398451 chr17:18023971 MYO15A -0.73 -10.55 -0.54 5.95e-22 Total body bone mineral density; CESC cis rs1728785 1.000 rs1645979 chr16:68603660 G/T cg02972257 chr16:68554789 NA -0.66 -7.4 -0.41 1.75e-12 Ulcerative colitis; CESC cis rs9914988 0.943 rs59461345 chr17:27151852 G/T cg20469991 chr17:27169893 C17orf63 -0.47 -5.13 -0.3 5.64e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg05564831 chr3:52568323 NT5DC2 0.48 7.76 0.43 1.85e-13 Electroencephalogram traits; CESC cis rs611744 0.669 rs13251024 chr8:109258333 T/C cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.65e-8 Dupuytren's disease; CESC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg07308232 chr7:1071921 C7orf50 -0.6 -8.45 -0.46 2.02e-15 Longevity;Endometriosis; CESC cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg24296786 chr1:45957014 TESK2 0.63 8.16 0.45 1.37e-14 High light scatter reticulocyte count; CESC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.37 -0.54 2.25e-21 Alzheimer's disease; CESC cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg06558623 chr16:89946397 TCF25 0.68 5.99 0.35 6.63e-9 Skin colour saturation; CESC cis rs9913156 0.793 rs55974786 chr17:4567564 T/C cg19197139 chr17:4613644 ARRB2 0.93 10.68 0.55 2.2e-22 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08156809 chr7:74071310 GTF2I 0.59 6.98 0.39 2.34e-11 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.69 -7.88 -0.44 8.71e-14 Gut microbiome composition (summer); CESC cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg06697600 chr4:7070879 GRPEL1 -0.49 -7.25 -0.41 4.68e-12 Monocyte percentage of white cells; CESC cis rs6963495 0.818 rs818619 chr7:105172505 A/T cg02135003 chr7:105160482 PUS7 -0.43 -5.98 -0.34 7.27e-9 Bipolar disorder (body mass index interaction); CESC cis rs3096299 0.935 rs3114890 chr16:89449546 C/G cg02187348 chr16:89574699 SPG7 0.54 7.08 0.4 1.28e-11 Multiple myeloma (IgH translocation); CESC trans rs7839040 0.698 rs10091992 chr8:82932881 T/C cg14472086 chr9:107730925 NA -0.46 -6.24 -0.36 1.69e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06581840 chr11:113644397 ZW10 -0.46 -6.0 -0.35 6.58e-9 Fibrinogen levels; CESC cis rs2243480 1.000 rs313807 chr7:65499481 C/T cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC cis rs1550582 1.000 rs62523710 chr8:135538773 T/C cg17885191 chr8:135476712 NA 0.65 7.28 0.41 3.73e-12 Educational attainment; CESC cis rs71403859 0.667 rs35538253 chr16:71677975 C/T cg08717414 chr16:71523259 ZNF19 -0.69 -5.81 -0.34 1.76e-8 Post bronchodilator FEV1; CESC cis rs116095464 0.510 rs55750776 chr5:230467 T/C cg10591111 chr5:226296 SDHA -0.54 -6.65 -0.38 1.72e-10 Breast cancer; CESC cis rs8017423 0.935 rs12884698 chr14:90750566 G/A cg14092571 chr14:90743983 NA 0.56 8.45 0.46 1.98e-15 Mortality in heart failure; CESC cis rs1832871 0.711 rs9459946 chr6:158707957 T/C cg07165851 chr6:158734300 TULP4 0.61 6.68 0.38 1.38e-10 Height; CESC cis rs7267005 0.661 rs2425085 chr20:34302402 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -5.35 -0.31 1.89e-7 Response to paliperidone in schizophrenia (Multivariate); CESC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg11890956 chr21:40555474 PSMG1 1.17 22.39 0.81 4.79e-63 Cognitive function; CESC cis rs559928 0.606 rs56311067 chr11:63931607 C/T cg18225595 chr11:63971243 STIP1 0.69 6.22 0.36 1.88e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs2072732 0.904 rs717795 chr1:2970464 T/C cg15211996 chr1:2936768 ACTRT2 0.29 5.24 0.31 3.25e-7 Plateletcrit; CESC cis rs6484504 0.576 rs286653 chr11:31227824 C/T cg14844989 chr11:31128820 NA -0.41 -5.77 -0.33 2.16e-8 Red blood cell count; CESC cis rs2235642 0.928 rs2076435 chr16:1607574 C/T cg07639376 chr16:1584516 IFT140;TMEM204 -0.32 -5.28 -0.31 2.74e-7 Coronary artery disease; CESC cis rs2637266 0.729 rs1099883 chr10:78516158 G/T cg18941641 chr10:78392320 NA 0.43 8.42 0.46 2.39e-15 Pulmonary function; CESC cis rs17253792 0.822 rs17683656 chr14:56053361 C/T cg24579896 chr14:56047964 C14orf33;KTN1 -0.83 -6.05 -0.35 4.84e-9 Putamen volume; CESC cis rs56163509 1 rs56163509 chr16:28864471 A/G cg08761264 chr16:28874980 SH2B1 -0.45 -5.49 -0.32 9.61e-8 Tonsillectomy;Mean corpuscular volume; CESC cis rs1847202 0.859 rs13096870 chr3:72948172 G/A cg10804678 chr3:72788309 NA -0.4 -5.29 -0.31 2.62e-7 Motion sickness; CESC cis rs2070997 0.607 rs7856783 chr9:133713507 T/C cg11464064 chr9:133710261 ABL1 0.72 8.06 0.44 2.58e-14 Response to amphetamines; CESC cis rs722599 0.683 rs10144860 chr14:75286426 T/C cg11812906 chr14:75593930 NEK9 0.45 5.45 0.32 1.14e-7 IgG glycosylation; CESC cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg08704250 chr15:31115839 NA -0.62 -7.97 -0.44 4.65e-14 Huntington's disease progression; CESC cis rs3026101 0.671 rs57406064 chr17:5300183 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs2180341 0.960 rs9401953 chr6:127687574 G/A cg27446573 chr6:127587934 RNF146 1.05 15.58 0.69 2.65e-39 Breast cancer; CESC cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg03433033 chr1:76189801 ACADM 0.69 8.23 0.45 8.67e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs8002861 0.905 rs12875768 chr13:44428305 C/T cg19180546 chr13:44453867 C13orf31;CCDC122 -0.44 -5.49 -0.32 9.55e-8 Leprosy; CESC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg27266027 chr21:40555129 PSMG1 -0.42 -5.45 -0.32 1.16e-7 Cognitive function; CESC cis rs5769765 1.000 rs2295409 chr22:50261060 G/C cg02269571 chr22:50332266 NA 0.46 6.2 0.36 2.13e-9 Schizophrenia; CESC cis rs4481887 0.927 rs10157089 chr1:248488157 A/G cg00666640 chr1:248458726 OR2T12 0.35 5.98 0.35 7.04e-9 Common traits (Other); CESC cis rs7640424 0.589 rs78673584 chr3:107813133 A/G cg09227934 chr3:107805635 CD47 -0.46 -5.65 -0.33 4.07e-8 Body mass index; CESC cis rs829883 1.000 rs249839 chr12:98872364 T/C cg25150519 chr12:98850993 NA 0.68 9.14 0.49 1.7e-17 Colorectal adenoma (advanced); CESC cis rs13106227 0.602 rs13152154 chr4:77417756 C/T cg20311846 chr4:77356250 SHROOM3 -0.32 -6.13 -0.35 3.21e-9 Eosinophilic esophagitis (pediatric); CESC cis rs910316 0.967 rs4899545 chr14:75568138 A/G cg08847533 chr14:75593920 NEK9 1.01 19.49 0.77 4.22e-53 Height; CESC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg13206674 chr6:150067644 NUP43 0.42 5.78 0.33 2.12e-8 Lung cancer; CESC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg05368731 chr17:41323189 NBR1 0.78 10.62 0.55 3.57e-22 Menopause (age at onset); CESC cis rs8064299 0.597 rs3785539 chr17:72775099 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.88 14.97 0.68 3.91e-37 Monocyte count; CESC cis rs8078723 0.674 rs9303284 chr17:38205793 C/T cg17467752 chr17:38218738 THRA -0.72 -11.25 -0.57 2.87e-24 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs67311347 1.000 rs10510708 chr3:40404770 A/G cg24209194 chr3:40518798 ZNF619 0.44 5.71 0.33 2.98e-8 Renal cell carcinoma; CESC cis rs12410462 0.681 rs115956039 chr1:227661978 G/A cg04117972 chr1:227635322 NA 0.8 6.85 0.39 5.16e-11 Major depressive disorder; CESC cis rs3747547 0.818 rs3827519 chr9:37948724 T/C cg13774184 chr9:37916125 SHB -0.57 -5.97 -0.34 7.8e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs2594989 1.000 rs2594993 chr3:11360744 C/T cg00170343 chr3:11313890 ATG7 0.59 5.25 0.31 3.1e-7 Circulating chemerin levels; CESC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg03647317 chr4:187891568 NA -0.44 -6.71 -0.38 1.15e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs10506458 0.915 rs2013050 chr12:63394310 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.34 -18.45 -0.75 1.83e-49 Hemostatic factors and hematological phenotypes; CESC cis rs2154427 0.938 rs113791275 chr21:34202806 A/C cg03746930 chr21:34165763 C21orf62;C21orf49 -0.53 -5.32 -0.31 2.17e-7 Bilirubin levels; CESC cis rs1062177 0.756 rs2915827 chr5:151119705 T/A cg12924095 chr5:151150029 G3BP1 -0.43 -5.34 -0.31 1.95e-7 Preschool internalizing problems; CESC cis rs1552244 0.748 rs9862221 chr3:10059658 G/T cg00166722 chr3:10149974 C3orf24 0.54 6.53 0.37 3.29e-10 Alzheimer's disease; CESC cis rs738322 1.000 rs133012 chr22:38570721 G/A cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC cis rs11098499 0.865 rs11722183 chr4:120280597 A/C cg09307838 chr4:120376055 NA 0.95 13.4 0.64 1.27e-31 Corneal astigmatism; CESC cis rs16854884 0.632 rs34038325 chr3:143685097 G/A cg06585982 chr3:143692056 C3orf58 0.48 6.01 0.35 6.11e-9 Economic and political preferences (feminism/equality); CESC cis rs4588572 0.779 rs3088102 chr5:77654679 G/A cg11547950 chr5:77652471 NA 0.49 6.47 0.37 4.74e-10 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00897250 chr12:569679 B4GALNT3 -0.62 -6.85 -0.39 5.23e-11 Gut microbiome composition (summer); CESC cis rs9906944 0.707 rs9912906 chr17:47104432 A/T cg09029085 chr17:47094198 IGF2BP1 0.25 5.06 0.3 7.94e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg00745463 chr17:30367425 LRRC37B 0.58 5.88 0.34 1.22e-8 Hip circumference adjusted for BMI; CESC cis rs72945132 0.882 rs72945194 chr11:70138621 A/G cg00319359 chr11:70116639 PPFIA1 0.81 7.38 0.41 2e-12 Coronary artery disease; CESC cis rs7586879 0.681 rs6723803 chr2:25120713 G/C cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.02e-11 Body mass index; CESC cis rs11711311 1.000 rs7649590 chr3:113447267 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.57 7.57 0.42 6.15e-13 IgG glycosylation; CESC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg02592271 chr2:27665507 KRTCAP3 -0.32 -6.55 -0.37 3e-10 Total body bone mineral density; CESC cis rs7191439 0.858 rs11076702 chr16:88774569 A/C cg27087555 chr16:88793112 FAM38A -1.4 -11.24 -0.57 3.18e-24 Plateletcrit; CESC cis rs72634258 0.945 rs7539255 chr1:8133352 T/C cg00042356 chr1:8021962 PARK7 0.82 7.73 0.43 2.19e-13 Inflammatory bowel disease; CESC cis rs116095464 1.000 rs62346511 chr5:208265 C/T cg22857025 chr5:266934 NA -1.27 -7.32 -0.41 2.92e-12 Breast cancer; CESC trans rs6137473 0.535 rs6082511 chr20:21773991 A/C cg01401824 chr2:159902017 TANC1 0.36 6.01 0.35 6.13e-9 Adolescent idiopathic scoliosis; CESC cis rs25645 0.830 rs4072639 chr17:38189049 G/A cg17467752 chr17:38218738 THRA -0.51 -6.61 -0.38 2.16e-10 Myeloid white cell count; CESC cis rs12042107 0.740 rs10922912 chr1:91207367 A/G cg13456504 chr1:91191583 NA -0.33 -5.67 -0.33 3.8e-8 Educational attainment; CESC cis rs7249142 0.549 rs741706 chr19:19281672 C/T cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.29 5.21 0.3 3.75e-7 IgG glycosylation; CESC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg09323728 chr8:95962352 TP53INP1 0.37 7.94 0.44 5.64e-14 Type 2 diabetes; CESC trans rs35365539 1 rs35365539 chr3:49794347 A/AC cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -8.49 -0.46 1.51e-15 Blood protein levels; CESC cis rs7927771 0.524 rs10838760 chr11:47786414 A/G cg18512352 chr11:47633146 NA 0.34 5.24 0.31 3.22e-7 Subjective well-being; CESC trans rs208520 1.000 rs208535 chr6:66962286 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -9.42 -0.5 2.36e-18 Exhaled nitric oxide output; CESC cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg18351406 chr4:77819688 ANKRD56 0.53 6.57 0.37 2.68e-10 Emphysema distribution in smoking; CESC cis rs2735413 0.958 rs2735401 chr16:78057103 A/C cg04733911 chr16:78082701 NA 0.46 7.14 0.4 8.82e-12 Systolic blood pressure (alcohol consumption interaction); CESC cis rs17826219 0.706 rs9893922 chr17:29068425 T/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Body mass index; CESC trans rs561341 1.000 rs473356 chr17:30321762 G/C cg27661571 chr11:113659931 NA -0.82 -7.63 -0.42 4.18e-13 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23288008 chr1:228296932 MRPL55 0.65 7.04 0.4 1.62e-11 Gut microbiome composition (summer); CESC trans rs61931739 0.500 rs7313094 chr12:34457508 T/C cg26384229 chr12:38710491 ALG10B 0.55 7.61 0.42 4.69e-13 Morning vs. evening chronotype; CESC cis rs4919694 0.611 rs76695159 chr10:105070837 C/T cg04362960 chr10:104952993 NT5C2 0.68 5.59 0.32 5.56e-8 Arsenic metabolism; CESC cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg18850127 chr7:39170497 POU6F2 0.37 5.16 0.3 4.8e-7 IgG glycosylation; CESC cis rs752092 0.925 rs8032007 chr15:101790817 C/T cg19997662 chr15:101784653 CHSY1 0.54 7.43 0.42 1.54e-12 Corneal structure; CESC cis rs7680126 0.596 rs10939835 chr4:10313750 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -5.25 -0.31 3.06e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs7089973 0.872 rs11818114 chr10:116634878 G/C cg23260525 chr10:116636907 FAM160B1 0.37 6.15 0.35 2.84e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9488822 0.676 rs1999929 chr6:116381994 T/C cg18764771 chr6:116381957 FRK 0.23 5.88 0.34 1.23e-8 Cholesterol, total;LDL cholesterol; CESC cis rs546131 0.928 rs552627 chr11:34826680 G/A cg06937548 chr11:34938143 PDHX;APIP 0.5 6.15 0.35 2.86e-9 Lung disease severity in cystic fibrosis; CESC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg17911788 chr17:44343683 NA 0.41 6.48 0.37 4.38e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1801251 0.963 rs66549961 chr2:233602293 A/G cg25237894 chr2:233734115 C2orf82 0.45 7.89 0.44 8.12e-14 Coronary artery disease; CESC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.29 0.81 1e-62 Prudent dietary pattern; CESC cis rs10791097 0.582 rs2282578 chr11:130735691 A/T cg12179176 chr11:130786555 SNX19 0.68 10.0 0.52 3.48e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9894429 1.000 rs12948099 chr17:79600799 C/G cg18240062 chr17:79603768 NPLOC4 0.74 10.37 0.54 2.3e-21 Eye color traits; CESC cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg01475377 chr6:109611718 NA -0.51 -8.46 -0.46 1.87e-15 Reticulocyte fraction of red cells; CESC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg03188948 chr7:1209495 NA 0.72 6.93 0.39 3.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1915146 0.546 rs2454055 chr10:126859832 T/C cg05090351 chr10:126851162 NA 0.61 9.36 0.5 3.44e-18 Menarche (age at onset); CESC cis rs5758659 0.652 rs133323 chr22:42405922 T/C cg15557168 chr22:42548783 NA -0.42 -6.27 -0.36 1.48e-9 Cognitive function; CESC cis rs367943 1.000 rs348944 chr5:112822925 C/T cg12552261 chr5:112820674 MCC -0.63 -7.96 -0.44 4.96e-14 Type 2 diabetes; CESC cis rs17095355 0.792 rs61881587 chr10:111759710 A/T cg00817464 chr10:111662876 XPNPEP1 -0.52 -5.92 -0.34 1.02e-8 Biliary atresia; CESC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg18337363 chr3:52569053 NT5DC2 0.29 5.16 0.3 4.95e-7 Electroencephalogram traits; CESC cis rs9897596 1 rs9897596 chr17:17593453 T/C cg04398451 chr17:18023971 MYO15A 0.38 5.15 0.3 5.19e-7 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9910055 0.573 rs228768 chr17:42191893 A/C cg09913183 chr17:42254507 C17orf65;ASB16 0.44 5.5 0.32 8.88e-8 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23649784 chr1:156105746 LMNA -0.66 -7.31 -0.41 3.16e-12 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.52 0.46 1.24e-15 Colonoscopy-negative controls vs population controls; CESC cis rs477692 0.583 rs12415589 chr10:131428336 C/G cg24747557 chr10:131355152 MGMT 0.38 5.38 0.31 1.62e-7 Response to temozolomide; CESC cis rs7772486 0.790 rs6926657 chr6:146255794 G/A cg05347473 chr6:146136440 FBXO30 -0.55 -7.0 -0.39 2.12e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4805272 0.512 rs765484 chr19:29344663 A/G cg12756686 chr19:29218302 NA 0.44 5.83 0.34 1.65e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs4974559 0.790 rs7654152 chr4:1325042 G/A cg02980000 chr4:1222292 CTBP1 0.82 7.38 0.41 2.1e-12 Systolic blood pressure; CESC cis rs9300255 0.566 rs10744150 chr12:123721614 A/C cg05973401 chr12:123451056 ABCB9 0.45 5.45 0.32 1.13e-7 Neutrophil percentage of white cells; CESC cis rs3815700 1.000 rs8100168 chr19:33093084 G/A cg02997394 chr19:33096574 ANKRD27 0.66 5.52 0.32 8.23e-8 Eosinophilic esophagitis; CESC cis rs12295403 0.964 rs34364314 chr11:18691674 G/A cg09887367 chr11:18690185 NA -0.4 -5.81 -0.34 1.82e-8 Ovarian reserve; CESC cis rs941873 0.868 rs10740497 chr10:81126380 T/C cg08514558 chr10:81106712 PPIF 0.36 6.22 0.36 1.94e-9 Height; CESC cis rs2479106 0.791 rs2536951 chr9:126646519 A/G cg16191174 chr9:126692580 DENND1A 0.48 6.53 0.37 3.39e-10 Polycystic ovary syndrome; CESC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.69 0.33 3.36e-8 Electroencephalogram traits; CESC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg27165867 chr14:105738592 BRF1 -0.52 -5.66 -0.33 3.92e-8 Mean platelet volume;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26764764 chr17:79077412 BAIAP2 -0.56 -6.16 -0.35 2.7e-9 Gut microbiome composition (summer); CESC cis rs2806561 0.734 rs11578046 chr1:23425139 G/A cg12483005 chr1:23474871 LUZP1 0.33 5.08 0.3 7.13e-7 Height; CESC cis rs9486719 1.000 rs11152951 chr6:96894135 C/G cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs698833 0.886 rs1056865 chr2:44546741 A/G cg04920474 chr2:44395004 PPM1B 0.36 5.16 0.3 4.92e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01755729 chr8:146012904 ZNF34 -0.46 -6.02 -0.35 5.66e-9 Fibrinogen levels; CESC cis rs1050631 0.564 rs948416 chr18:33715673 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.53 7.12 0.4 9.97e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs9303280 0.743 rs2941522 chr17:37910368 C/T cg19468946 chr17:37922297 IKZF3 0.41 5.75 0.33 2.39e-8 Self-reported allergy; CESC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg00990874 chr7:1149470 C7orf50 0.48 5.22 0.31 3.56e-7 Bronchopulmonary dysplasia; CESC cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg24296786 chr1:45957014 TESK2 0.64 8.34 0.46 4.05e-15 High light scatter reticulocyte count; CESC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg17949981 chr6:28129498 ZNF389 0.44 5.39 0.31 1.55e-7 Depression; CESC cis rs9815354 0.638 rs73069277 chr3:41967521 C/T cg03022575 chr3:42003672 ULK4 0.67 5.96 0.34 7.91e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs4268898 0.560 rs78711174 chr2:24496531 G/A cg06627628 chr2:24431161 ITSN2 -0.97 -10.74 -0.55 1.39e-22 Asthma; CESC cis rs7122539 0.506 rs10791896 chr11:66689240 G/T cg24851651 chr11:66362959 CCS 0.4 5.78 0.33 2.08e-8 HIV-1 susceptibility; CESC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.95 9.59 0.51 7e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs873946 0.564 rs2803992 chr10:134550882 T/C cg27286337 chr10:134555280 INPP5A 0.71 8.81 0.48 1.66e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs55871839 0.708 rs4738731 chr8:59809840 C/G cg07426533 chr8:59803705 TOX -0.45 -6.74 -0.38 9.7e-11 Pneumonia; CESC cis rs258892 0.895 rs34672 chr5:72165389 G/A cg21869765 chr5:72125136 TNPO1 0.44 5.6 0.33 5.41e-8 Small cell lung carcinoma; CESC cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg19626725 chr5:178986131 RUFY1 0.35 5.17 0.3 4.57e-7 Lung cancer; CESC cis rs916888 0.773 rs199457 chr17:44795469 C/T cg27589368 chr17:43923255 LOC100128977;IMP5 -0.39 -5.24 -0.31 3.31e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs4964805 0.632 rs9706225 chr12:104188086 T/C cg02344784 chr12:104178138 NT5DC3 0.46 6.57 0.37 2.73e-10 Attention deficit hyperactivity disorder; CESC cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg02297831 chr4:17616191 MED28 0.61 7.77 0.43 1.76e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1975974 0.935 rs11870387 chr17:21730236 G/C cg18423549 chr17:21743878 NA -0.53 -7.11 -0.4 1.07e-11 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07752194 chr10:126686658 CTBP2 -0.53 -6.05 -0.35 4.95e-9 Gut microbiome composition (summer); CESC cis rs8062405 0.690 rs7187604 chr16:28565953 A/G cg07382826 chr16:28625726 SULT1A1 0.4 6.56 0.37 2.87e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs526821 0.595 rs608964 chr11:55339266 G/A cg15704280 chr7:45808275 SEPT13 -0.51 -6.28 -0.36 1.41e-9 Pediatric bone mineral density (spine); CESC cis rs796364 1.000 rs11680723 chr2:200810957 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 -1.03 -7.96 -0.44 5.03e-14 Schizophrenia; CESC cis rs7084402 0.967 rs1658440 chr10:60323933 T/A cg07615347 chr10:60278583 BICC1 0.61 9.62 0.51 5.56e-19 Refractive error; CESC cis rs2239815 0.576 rs10427628 chr22:29239766 T/C cg02153584 chr22:29168773 CCDC117 0.45 5.06 0.3 7.89e-7 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; CESC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg13206674 chr6:150067644 NUP43 0.45 6.47 0.37 4.82e-10 Lung cancer; CESC cis rs12586317 0.513 rs11156871 chr14:35481196 G/A cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg22800045 chr5:56110881 MAP3K1 0.81 9.66 0.51 4.1e-19 Initial pursuit acceleration; CESC cis rs3087591 1.000 rs8082020 chr17:29694795 G/A cg24425628 chr17:29625626 OMG;NF1 -0.51 -6.4 -0.37 7.01e-10 Hip circumference; CESC cis rs7208859 0.524 rs59923796 chr17:29064919 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.31 0.36 1.17e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22984404 chr17:30469399 RHOT1 0.56 6.17 0.35 2.52e-9 Gut microbiome composition (summer); CESC cis rs61332075 0.518 rs6749508 chr2:239456243 C/T cg18131467 chr2:239335373 ASB1 -0.58 -6.02 -0.35 5.69e-9 Lung function (FEV1/FVC); CESC cis rs3749237 0.595 rs2878298 chr3:49406080 T/C cg03060546 chr3:49711283 APEH 0.75 11.29 0.57 2.17e-24 Resting heart rate; CESC cis rs2204008 0.840 rs3892363 chr12:38479487 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.11 0.35 3.63e-9 Bladder cancer; CESC cis rs7193541 0.694 rs3896277 chr16:74480694 A/T cg01733217 chr16:74700730 RFWD3 0.7 10.3 0.53 3.88e-21 Multiple myeloma; CESC cis rs3733585 0.699 rs11724510 chr4:9958583 C/T cg02734326 chr4:10020555 SLC2A9 -0.44 -6.11 -0.35 3.58e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg25405998 chr7:65216604 CCT6P1 0.5 5.42 0.32 1.36e-7 Aortic root size; CESC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg03351412 chr1:154909251 PMVK -0.7 -9.39 -0.5 2.9e-18 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21250466 chr4:854474 GAK -0.65 -7.77 -0.43 1.78e-13 Gut microbiome composition (summer); CESC trans rs9858542 0.953 rs7646366 chr3:49470668 G/A cg21659725 chr3:3221576 CRBN -0.56 -6.63 -0.38 1.83e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1185460 1.000 rs1185460 chr11:118943433 C/T cg01677386 chr11:118938358 VPS11 0.42 5.03 0.3 8.94e-7 Coronary artery disease; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg25722142 chr6:139695762 CITED2 -0.49 -6.58 -0.37 2.56e-10 Height; CESC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg24531977 chr5:56204891 C5orf35 -0.56 -7.46 -0.42 1.25e-12 Coronary artery disease; CESC cis rs5167 0.504 rs3760625 chr19:45456941 G/A cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.51e-10 Blood protein levels; CESC cis rs8078723 0.510 rs11655264 chr17:38138995 G/C cg17467752 chr17:38218738 THRA -0.48 -7.01 -0.4 2.03e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs1670533 0.818 rs585735 chr4:1080391 G/C cg04106633 chr4:1044584 NA 0.4 5.1 0.3 6.33e-7 Recombination rate (females); CESC cis rs938554 0.692 rs4428284 chr4:9996392 A/T cg00071950 chr4:10020882 SLC2A9 0.62 6.86 0.39 4.97e-11 Blood metabolite levels; CESC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg02951883 chr7:2050386 MAD1L1 -0.46 -5.99 -0.35 6.84e-9 Bipolar disorder and schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24029926 chr7:33102655 NT5C3 -0.46 -6.23 -0.36 1.82e-9 Gut microbiota (bacterial taxa); CESC cis rs3820068 0.705 rs72643701 chr1:15866219 G/A cg18192808 chr1:15853278 DNAJC16 0.43 5.28 0.31 2.66e-7 Systolic blood pressure; CESC cis rs6582630 0.560 rs12315134 chr12:38419857 T/A cg26384229 chr12:38710491 ALG10B -0.41 -5.49 -0.32 9.35e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs3820928 0.839 rs35068645 chr2:227844265 T/C cg11843606 chr2:227700838 RHBDD1 -0.45 -5.78 -0.33 2.15e-8 Pulmonary function; CESC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg12463550 chr7:65579703 CRCP -0.47 -5.97 -0.34 7.71e-9 Aortic root size; CESC cis rs2354432 0.505 rs7551766 chr1:146858964 A/G cg25205988 chr1:146714368 CHD1L -1.03 -8.43 -0.46 2.28e-15 Mitochondrial DNA levels; CESC cis rs1801251 1.000 rs11555646 chr2:233599904 A/C cg08000102 chr2:233561755 GIGYF2 0.69 9.8 0.52 1.48e-19 Coronary artery disease; CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg16103275 chr6:290800 DUSP22 -0.43 -6.09 -0.35 3.86e-9 Menopause (age at onset); CESC cis rs8180040 0.764 rs6794193 chr3:47114904 T/C cg27129171 chr3:47204927 SETD2 0.7 10.49 0.54 9.21e-22 Colorectal cancer; CESC cis rs10489525 0.599 rs17033129 chr1:115611539 C/T cg01522456 chr1:115632236 TSPAN2 0.45 5.58 0.32 6.08e-8 Autism; CESC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg24562669 chr7:97807699 LMTK2 0.51 7.57 0.42 6.13e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg10819733 chr22:24237672 NA -0.37 -5.22 -0.31 3.59e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6800768 0.633 rs7623348 chr3:24130263 C/A cg10674438 chr3:24145617 LOC152024 -0.42 -5.63 -0.33 4.69e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6500602 0.653 rs3747579 chr16:4445327 A/G cg08645402 chr16:4508243 NA -0.39 -5.6 -0.33 5.29e-8 Schizophrenia; CESC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg06634786 chr22:41940651 POLR3H 0.71 7.13 0.4 9.54e-12 Vitiligo; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg07236798 chr8:131455818 NA -0.41 -6.05 -0.35 4.89e-9 Breast cancer; CESC cis rs9354308 0.771 rs2814100 chr6:66528107 A/G cg07460842 chr6:66804631 NA 0.51 5.58 0.32 6.05e-8 Metabolite levels; CESC cis rs362272 0.545 rs2239725 chr4:3305739 C/T cg14583973 chr4:3374767 RGS12 0.32 5.48 0.32 9.89e-8 Serum sulfate level; CESC cis rs7851660 0.809 rs10512255 chr9:100652582 C/T cg13688889 chr9:100608707 NA -0.66 -9.14 -0.49 1.64e-17 Strep throat; CESC cis rs7589342 0.839 rs10192144 chr2:106439854 A/G cg16077055 chr2:106428750 NCK2 0.48 6.88 0.39 4.33e-11 Addiction; CESC cis rs362296 0.698 rs362282 chr4:3259671 G/A cg08886695 chr4:3369023 RGS12 0.43 5.75 0.33 2.52e-8 Parental longevity (mother's age at death); CESC cis rs9815354 1.000 rs2128835 chr3:41862873 A/G cg03022575 chr3:42003672 ULK4 0.48 5.3 0.31 2.46e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9430161 0.645 rs6675082 chr1:11033797 T/C cg27631724 chr1:11040367 C1orf127 0.37 5.92 0.34 1.01e-8 Ewing sarcoma; CESC cis rs10870270 1.000 rs11146354 chr10:133774757 A/G cg08754478 chr10:133766260 PPP2R2D -0.59 -7.57 -0.42 6.29e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs12220238 1.000 rs7909915 chr10:75960942 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.44 0.32 1.24e-7 Soluble interleukin-2 receptor subunit alpha; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23692589 chr11:67256716 AIP 0.46 6.84 0.39 5.35e-11 Fibrinogen levels; CESC cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.59 6.66 0.38 1.55e-10 Multiple sclerosis; CESC cis rs7772486 0.686 rs9376961 chr6:146048737 C/T cg23711669 chr6:146136114 FBXO30 0.88 12.91 0.62 6.46e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs10197940 0.624 rs17270233 chr2:152372420 A/G cg19508488 chr2:152266495 RIF1 0.51 5.39 0.31 1.56e-7 Lung cancer; CESC cis rs10129255 0.957 rs8009464 chr14:107185850 C/T cg23076370 chr14:107095027 NA -0.48 -6.25 -0.36 1.65e-9 Kawasaki disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16931877 chr3:32726605 CNOT10 -0.47 -6.32 -0.36 1.11e-9 Fibrinogen levels; CESC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.22 0.45 8.86e-15 Menopause (age at onset); CESC cis rs9300255 0.507 rs1727302 chr12:123632930 G/A cg05973401 chr12:123451056 ABCB9 0.49 5.89 0.34 1.15e-8 Neutrophil percentage of white cells; CESC cis rs7937682 0.737 rs542275 chr11:111431614 C/T cg09085632 chr11:111637200 PPP2R1B -0.8 -11.09 -0.56 9.9e-24 Primary sclerosing cholangitis; CESC cis rs11577318 0.853 rs11803933 chr1:26629465 G/C cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.46 -0.37 5.05e-10 Granulocyte percentage of myeloid white cells; CESC cis rs10200159 1.000 rs6717574 chr2:55821846 A/G cg13617705 chr2:55845095 SMEK2 0.68 5.13 0.3 5.68e-7 Vitiligo; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03758918 chr6:45389877 RUNX2 -0.5 -6.2 -0.36 2.1e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09321108 chr11:47870340 NUP160 0.57 6.27 0.36 1.48e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg26338869 chr17:61819248 STRADA 0.69 9.08 0.49 2.62e-17 Prudent dietary pattern; CESC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.37 0.36 8.15e-10 Bipolar disorder; CESC cis rs6570726 0.935 rs421268 chr6:145845558 A/T cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 2e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs7191439 0.858 rs11076701 chr16:88774525 A/G cg27087555 chr16:88793112 FAM38A -1.25 -10.49 -0.54 9.1e-22 Plateletcrit; CESC cis rs9487051 0.676 rs6929438 chr6:109595506 C/T cg21918786 chr6:109611834 NA -0.37 -5.49 -0.32 9.35e-8 Reticulocyte fraction of red cells; CESC cis rs910316 1.000 rs4903284 chr14:75592483 G/C cg08847533 chr14:75593920 NEK9 0.99 18.93 0.76 3.76e-51 Height; CESC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg05834625 chr6:170176447 C6orf70 0.48 6.75 0.38 9.44e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs79349575 0.777 rs28517720 chr17:46976756 C/G cg16584676 chr17:46985605 UBE2Z 0.53 6.58 0.37 2.57e-10 Type 2 diabetes; CESC cis rs2243480 0.708 rs781141 chr7:65438553 A/G cg25894440 chr7:65020034 NA -0.6 -5.31 -0.31 2.38e-7 Diabetic kidney disease; CESC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs807669 0.525 rs9604934 chr22:19194868 C/T cg02655711 chr22:19163373 SLC25A1 0.43 6.42 0.37 6.15e-10 Metabolite levels; CESC cis rs453301 0.522 rs1964356 chr8:8853270 G/T cg06636001 chr8:8085503 FLJ10661 0.41 5.42 0.32 1.32e-7 Joint mobility (Beighton score); CESC cis rs1200821 0.535 rs1208783 chr10:37767467 A/G cg25427524 chr10:38739819 LOC399744 -0.42 -5.48 -0.32 1e-7 Hemostatic factors and hematological phenotypes; CESC cis rs3733418 0.860 rs12647419 chr4:165929153 G/A cg10852876 chr4:165953100 TRIM60 -0.46 -5.37 -0.31 1.75e-7 Obesity-related traits; CESC cis rs3105593 1.000 rs3109881 chr15:50839272 G/A cg08437265 chr15:50716283 USP8 0.43 5.62 0.33 4.77e-8 QT interval; CESC cis rs1949733 0.523 rs55977448 chr4:8542918 G/T cg11789530 chr4:8429930 ACOX3 -0.57 -7.18 -0.4 6.97e-12 Response to antineoplastic agents; CESC cis rs909341 0.710 rs6089953 chr20:62291008 C/T cg03999872 chr20:62272968 STMN3 -0.55 -5.62 -0.33 4.95e-8 Atopic dermatitis; CESC cis rs12497850 0.931 rs11920534 chr3:48937761 G/T cg03060546 chr3:49711283 APEH 0.46 5.79 0.33 2.02e-8 Parkinson's disease; CESC cis rs7296418 0.580 rs78455769 chr12:123856443 G/A cg00376283 chr12:123451042 ABCB9 0.57 7.77 0.43 1.76e-13 Platelet count; CESC cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg05340658 chr4:99064831 C4orf37 0.75 10.89 0.56 4.51e-23 Colonoscopy-negative controls vs population controls; CESC cis rs524023 0.881 rs544838 chr11:64429059 T/C cg07220939 chr11:64358617 SLC22A12 -0.34 -5.32 -0.31 2.19e-7 Urate levels in obese individuals; CESC trans rs9325144 0.555 rs12424003 chr12:38688140 C/T cg23762105 chr12:34175262 ALG10 0.48 6.28 0.36 1.36e-9 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs56127718 chr5:270273 G/T cg22857025 chr5:266934 NA -1.3 -18.8 -0.76 1.12e-50 Breast cancer; CESC trans rs1814175 0.817 rs10839318 chr11:49657511 G/C cg03929089 chr4:120376271 NA -0.94 -15.58 -0.69 2.69e-39 Height; CESC cis rs7772486 0.875 rs9403764 chr6:146360582 G/A cg05347473 chr6:146136440 FBXO30 0.5 6.5 0.37 3.88e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs3762637 0.943 rs6762156 chr3:122236025 A/C cg24169773 chr3:122142474 KPNA1 -0.59 -6.94 -0.39 3.01e-11 LDL cholesterol levels; CESC cis rs17362650 0.653 rs13020173 chr2:9548651 T/G cg12832956 chr2:9616023 IAH1 -0.57 -6.38 -0.36 7.96e-10 Alcohol dependence (age at onset); CESC cis rs9640161 0.830 rs76741564 chr7:150059529 A/T cg10018233 chr7:150070692 REPIN1 0.37 5.72 0.33 2.84e-8 Blood protein levels;Circulating chemerin levels; CESC trans rs1545843 0.595 rs61929351 chr12:84793647 C/A cg03015433 chr16:56623111 MT3 -0.34 -6.12 -0.35 3.37e-9 Major depressive disorder; CESC cis rs6433857 0.657 rs2368178 chr2:181501938 T/C cg23363182 chr2:181467187 NA -0.45 -6.8 -0.39 6.88e-11 Body mass index; CESC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg14562523 chr21:43528734 C21orf128;UMODL1 -0.39 -5.72 -0.33 2.85e-8 IgG glycosylation; CESC cis rs1387259 0.723 rs2732488 chr12:48771444 G/A cg04545296 chr12:48745243 ZNF641 0.36 6.01 0.35 6.28e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg04553112 chr3:125709451 NA -0.54 -5.82 -0.34 1.71e-8 Blood pressure (smoking interaction); CESC cis rs6088580 0.634 rs4911422 chr20:32999345 T/C cg08999081 chr20:33150536 PIGU -0.65 -11.29 -0.57 2.22e-24 Glomerular filtration rate (creatinine); CESC cis rs9291683 0.620 rs717615 chr4:10104670 C/T cg11266682 chr4:10021025 SLC2A9 0.5 9.39 0.5 2.81e-18 Bone mineral density; CESC cis rs950169 1.000 rs1848093 chr15:84755527 G/C cg17507749 chr15:85114479 UBE2QP1 0.64 7.11 0.4 1.11e-11 Schizophrenia; CESC cis rs2573652 1.000 rs2727198 chr15:100513722 T/C cg09918751 chr15:100517450 ADAMTS17 -0.38 -7.34 -0.41 2.67e-12 Height; CESC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg11764359 chr7:65958608 NA -0.68 -8.81 -0.48 1.68e-16 Aortic root size; CESC cis rs75229567 0.618 rs35394896 chr12:70188346 T/A cg10114359 chr12:70132523 RAB3IP 0.75 5.7 0.33 3.26e-8 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13047596 chr2:233735017 C2orf82 -0.45 -6.03 -0.35 5.54e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3820068 0.603 rs6429753 chr1:15900537 A/G cg17385448 chr1:15911702 AGMAT 0.36 5.56 0.32 6.55e-8 Systolic blood pressure; CESC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg04315214 chr1:2043799 PRKCZ 0.61 10.47 0.54 1.08e-21 Height; CESC cis rs12142240 0.660 rs72886903 chr1:46813860 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs763014 0.931 rs1981483 chr16:630665 G/A cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.35e-9 Height; CESC cis rs8018808 0.791 rs2205190 chr14:77886723 T/G cg20045696 chr14:77926864 AHSA1 0.43 5.84 0.34 1.52e-8 Myeloid white cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11142944 chr22:35653622 HMGXB4 0.59 6.6 0.38 2.2e-10 Gut microbiome composition (summer); CESC cis rs6582630 0.502 rs11495393 chr12:38341194 T/C cg26384229 chr12:38710491 ALG10B 0.68 10.14 0.53 1.29e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs7819412 0.522 rs4841497 chr8:10985140 A/G cg21775007 chr8:11205619 TDH -0.39 -5.3 -0.31 2.41e-7 Triglycerides; CESC cis rs7216064 1.000 rs56148300 chr17:65892752 T/C cg07042672 chr17:66097459 LOC651250 -0.61 -7.5 -0.42 9.45e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs35740288 0.545 rs11637283 chr15:86316103 C/T cg20737812 chr15:86336631 KLHL25 -0.44 -5.22 -0.31 3.61e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs57221529 0.709 rs72707023 chr5:667620 G/A cg16447950 chr5:562315 NA -0.64 -6.51 -0.37 3.79e-10 Lung disease severity in cystic fibrosis; CESC cis rs7584330 0.737 rs1497127 chr2:238369282 A/G cg14458575 chr2:238380390 NA 0.54 7.82 0.43 1.27e-13 Prostate cancer; CESC cis rs4965006 0.591 rs4964913 chr12:132412488 C/A cg00588090 chr12:132412438 PUS1 -0.56 -8.36 -0.46 3.65e-15 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs7714584 1.000 rs2115069 chr5:150252365 G/A cg22134413 chr5:150180641 NA 0.55 6.08 0.35 4.25e-9 Crohn's disease; CESC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg27266027 chr21:40555129 PSMG1 0.47 5.67 0.33 3.69e-8 Cognitive function; CESC cis rs7208859 0.623 rs216423 chr17:28942109 G/C cg04154034 chr17:28927549 LRRC37B2 0.68 6.16 0.35 2.69e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs116161686 0.500 rs76610459 chr1:210050756 T/G cg25204440 chr1:209979598 IRF6 0.64 6.07 0.35 4.36e-9 Coronary artery disease; CESC cis rs10752881 1.000 rs12028732 chr1:182985525 G/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.79e-31 Colorectal cancer; CESC cis rs6424115 0.830 rs3003335 chr1:24200052 A/G cg10978503 chr1:24200527 CNR2 0.33 6.63 0.38 1.85e-10 Immature fraction of reticulocytes; CESC cis rs11690935 0.595 rs788170 chr2:172919958 T/C cg13550731 chr2:172543902 DYNC1I2 0.5 6.78 0.38 7.88e-11 Schizophrenia; CESC cis rs1915146 0.546 rs9422857 chr10:126861278 C/G cg05090351 chr10:126851162 NA 0.61 9.35 0.5 3.7e-18 Menarche (age at onset); CESC cis rs6541297 0.941 rs6665258 chr1:230279058 G/A cg20703242 chr1:230279135 GALNT2 0.68 10.87 0.56 5.47e-23 Coronary artery disease; CESC cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg15541040 chr2:3486749 NA -0.44 -5.67 -0.33 3.81e-8 Neurofibrillary tangles; CESC cis rs7020830 0.861 rs13289001 chr9:37311592 A/G cg14294708 chr9:37120828 ZCCHC7 1.25 24.48 0.83 5.59e-70 Schizophrenia; CESC cis rs559928 0.606 rs7941773 chr11:63952759 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 5.82 0.34 1.7e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg17366294 chr4:99064904 C4orf37 0.59 8.47 0.46 1.71e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.752 rs28568986 chr1:46207743 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7605827 0.930 rs1473178 chr2:15576750 T/C cg19274914 chr2:15703543 NA 0.34 6.07 0.35 4.38e-9 Educational attainment (years of education); CESC cis rs3782089 0.744 rs11545200 chr11:65319751 G/A cg00206168 chr11:65308501 LTBP3 0.99 6.62 0.38 2.04e-10 Height; CESC cis rs4974559 0.739 rs28411197 chr4:1279781 C/T cg02980000 chr4:1222292 CTBP1 0.81 7.39 0.41 1.88e-12 Systolic blood pressure; CESC trans rs7922314 0.571 rs16918003 chr10:64751852 T/C cg06935979 chr1:232941706 KIAA1383 -0.62 -6.02 -0.35 5.84e-9 Cutaneous psoriasis; CESC cis rs9430161 0.644 rs6685766 chr1:11037051 T/C cg02454025 chr1:11042201 C1orf127 0.93 14.49 0.66 1.93e-35 Ewing sarcoma; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg12692187 chr10:94353140 KIF11 0.48 6.04 0.35 5.32e-9 Thyroid stimulating hormone; CESC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg09323728 chr8:95962352 TP53INP1 -0.41 -8.97 -0.48 5.44e-17 Type 2 diabetes; CESC cis rs2404602 0.692 rs7350777 chr15:76985441 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.56 -0.32 6.68e-8 Blood metabolite levels; CESC cis rs3820068 0.581 rs74054797 chr1:15926217 G/A cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs6690583 0.623 rs12047435 chr1:85452927 T/G cg22153463 chr1:85462885 MCOLN2 0.73 7.14 0.4 8.84e-12 Serum sulfate level; CESC cis rs138880 0.542 rs9616215 chr22:50318834 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.66 -5.4 -0.31 1.5e-7 Schizophrenia; CESC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg22862634 chr11:62369728 EML3;MTA2 -0.47 -6.58 -0.37 2.45e-10 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs1665050 1.000 rs1665050 chr15:59293605 A/G cg05156742 chr15:59063176 FAM63B -0.46 -5.58 -0.32 6.01e-8 Atopic dermatitis; CESC cis rs7188697 0.885 rs1646010 chr16:58549204 G/C cg21335942 chr16:58549945 SETD6 0.46 5.29 0.31 2.55e-7 QT interval; CESC cis rs1018836 0.608 rs6982329 chr8:91467488 A/G cg16814680 chr8:91681699 NA -0.51 -7.05 -0.4 1.55e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs10864907 0.614 rs12711745 chr2:113700355 T/C cg12858261 chr2:113808755 IL1F8 0.45 5.47 0.32 1.03e-7 Pulmonary function; CESC cis rs9905704 0.587 rs2003537 chr17:56611871 C/G cg12560992 chr17:57184187 TRIM37 -0.65 -6.19 -0.36 2.29e-9 Testicular germ cell tumor; CESC cis rs2439831 0.850 rs8023458 chr15:44080939 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.78 0.43 1.66e-13 Lung cancer in ever smokers; CESC cis rs2108225 0.872 rs7792139 chr7:107445433 G/A cg18560240 chr7:107437656 SLC26A3 -0.41 -5.56 -0.32 6.54e-8 Ulcerative colitis; CESC trans rs11098499 0.865 rs11098513 chr4:120316075 A/G cg25214090 chr10:38739885 LOC399744 0.66 8.84 0.48 1.32e-16 Corneal astigmatism; CESC cis rs3820928 0.874 rs12467261 chr2:227888838 T/C cg05526886 chr2:227700861 RHBDD1 -0.45 -5.75 -0.33 2.4e-8 Pulmonary function; CESC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg16606324 chr3:10149918 C3orf24 0.43 5.22 0.31 3.71e-7 Alzheimer's disease; CESC cis rs1055129 0.560 rs2305913 chr17:73922941 T/C cg02678768 chr17:74002944 EVPL 0.41 5.77 0.33 2.17e-8 White matter hyperintensity burden; CESC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg02428538 chr16:24856791 SLC5A11 -0.6 -6.2 -0.36 2.13e-9 Intelligence (multi-trait analysis); CESC trans rs4596713 0.508 rs59620993 chr9:71771911 C/T cg16512924 chr15:28394682 HERC2 0.5 6.29 0.36 1.33e-9 Headache; CESC cis rs1874326 0.524 rs6968570 chr7:138110039 T/G cg18008034 chr7:138118925 NA -0.41 -5.14 -0.3 5.34e-7 Quantitative traits; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg18404041 chr3:52824283 ITIH1 -0.37 -6.63 -0.38 1.83e-10 Electroencephalogram traits; CESC cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.85e-8 Lung cancer; CESC cis rs2228479 0.702 rs62052710 chr16:89854893 C/T cg19635926 chr16:89946313 TCF25 0.67 5.08 0.3 7.19e-7 Skin colour saturation; CESC cis rs3812565 0.530 rs10781538 chr9:139320929 C/G cg14169450 chr9:139327907 INPP5E -0.54 -8.7 -0.47 3.65e-16 Granulocyte percentage of myeloid white cells; CESC trans rs11098499 0.954 rs7654587 chr4:120388406 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.93 0.52 5.63e-20 Corneal astigmatism; CESC cis rs60154123 0.686 rs227222 chr1:210191272 T/C cg21951975 chr1:209979733 IRF6 -0.56 -5.22 -0.31 3.6e-7 Coronary artery disease; CESC trans rs877282 0.853 rs11595507 chr10:756703 C/T cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs858239 0.539 rs57864591 chr7:23184424 T/A cg23682824 chr7:23144976 KLHL7 0.51 6.69 0.38 1.29e-10 Cerebrospinal fluid biomarker levels; CESC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -8.42 -0.46 2.34e-15 Alzheimer's disease; CESC trans rs57221529 0.709 rs72703034 chr5:577101 C/T cg25482853 chr8:67687455 SGK3 1.01 10.17 0.53 9.74e-21 Lung disease severity in cystic fibrosis; CESC cis rs11098499 0.954 rs12510138 chr4:120423935 C/G cg09307838 chr4:120376055 NA 0.92 13.14 0.63 1.02e-30 Corneal astigmatism; CESC cis rs13106227 0.550 rs1398017 chr4:77372902 T/C cg20311846 chr4:77356250 SHROOM3 -0.31 -5.67 -0.33 3.65e-8 Eosinophilic esophagitis (pediatric); CESC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.78e-7 Colonoscopy-negative controls vs population controls; CESC cis rs921968 0.565 rs2272188 chr2:219612282 C/T cg02176678 chr2:219576539 TTLL4 0.46 8.22 0.45 9.16e-15 Mean corpuscular hemoglobin concentration; CESC cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg15017067 chr4:17643749 FAM184B 0.36 5.11 0.3 6.26e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs62103177 0.733 rs62103193 chr18:77629217 C/T cg05926928 chr17:57297772 GDPD1 1.18 10.14 0.53 1.27e-20 Opioid sensitivity; CESC cis rs7000551 0.675 rs2443503 chr8:22381850 A/G cg12081754 chr8:22256438 SLC39A14 0.44 5.86 0.34 1.37e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs4253772 0.591 rs739165 chr22:46684528 C/T cg00784671 chr22:46762841 CELSR1 -0.58 -5.83 -0.34 1.57e-8 LDL cholesterol;Cholesterol, total; CESC cis rs3796352 1.000 rs34340609 chr3:53077276 A/G cg07884673 chr3:53033167 SFMBT1 0.53 5.16 0.3 4.74e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs7178572 0.568 rs4886856 chr15:77510585 A/G cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.29 0.45 5.87e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09199933 chr17:41561366 DHX8 -0.47 -6.31 -0.36 1.17e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg08308459 chr2:38893161 GALM -0.53 -6.47 -0.37 4.75e-10 5-HTT brain serotonin transporter levels; CESC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.4 -0.37 7.08e-10 Life satisfaction; CESC trans rs877282 0.842 rs35117541 chr10:764683 C/T cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg23958373 chr8:599963 NA 0.81 5.87 0.34 1.27e-8 IgG glycosylation; CESC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg02569458 chr12:86230093 RASSF9 0.51 7.7 0.43 2.65e-13 Major depressive disorder; CESC cis rs67311347 1.000 rs34762643 chr3:40475433 C/T cg09455208 chr3:40491958 NA 0.44 7.53 0.42 8.04e-13 Renal cell carcinoma; CESC cis rs6831352 0.691 rs2602887 chr4:100041473 A/G cg13256891 chr4:100009986 ADH5 0.71 7.42 0.41 1.62e-12 Alcohol dependence; CESC cis rs10256972 0.527 rs2949170 chr7:1216438 A/G cg18765753 chr7:1198926 ZFAND2A -0.48 -6.8 -0.39 6.94e-11 Longevity;Endometriosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09985698 chr21:45759020 C21orf2 -0.46 -6.02 -0.35 5.85e-9 Fibrinogen levels; CESC cis rs2243480 1.000 rs4548056 chr7:65298873 A/G cg12463550 chr7:65579703 CRCP 0.7 5.83 0.34 1.6e-8 Diabetic kidney disease; CESC cis rs6754311 0.731 rs2322660 chr2:136557319 A/G cg15123519 chr2:136567270 LCT -0.34 -5.81 -0.34 1.76e-8 Mosquito bite size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05943971 chr1:151763686 TDRKH -0.51 -6.08 -0.35 4.08e-9 Ulcerative colitis; CESC cis rs9916302 0.706 rs8182252 chr17:37727950 T/C cg15445000 chr17:37608096 MED1 -0.37 -5.15 -0.3 5.01e-7 Glomerular filtration rate (creatinine); CESC cis rs9913156 0.793 rs72835642 chr17:4573407 T/C cg00122941 chr17:4613640 ARRB2 0.88 10.19 0.53 8.39e-21 Lymphocyte counts; CESC cis rs854765 0.663 rs1108648 chr17:17750558 G/A cg04398451 chr17:18023971 MYO15A 0.66 9.54 0.51 9.7e-19 Total body bone mineral density; CESC cis rs2066819 1.000 rs17118403 chr12:56630067 C/T cg26734620 chr12:56694298 CS 1.05 6.75 0.38 9.35e-11 Psoriasis vulgaris; CESC cis rs3008870 0.755 rs2815362 chr1:67496803 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 7.83 0.43 1.17e-13 Lymphocyte percentage of white cells; CESC cis rs1962636 1 rs1962636 chr16:22064395 A/C cg09370801 chr16:22207107 NA 0.55 8.18 0.45 1.18e-14 Schizophrenia; CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg04025307 chr7:1156635 C7orf50 0.41 5.21 0.31 3.71e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs478304 0.651 rs4930319 chr11:65555458 G/C cg10518572 chr11:65560635 OVOL1 -0.31 -5.8 -0.34 1.91e-8 Acne (severe); CESC cis rs9611565 0.546 rs739132 chr22:42123099 A/T cg17376030 chr22:41985996 PMM1 -0.79 -8.55 -0.46 1e-15 Vitiligo; CESC cis rs820218 0.886 rs820158 chr17:73660179 A/G cg01592526 chr17:73663357 RECQL5;SAP30BP 0.44 5.6 0.33 5.49e-8 Rotator cuff tears; CESC cis rs710216 0.917 rs3754223 chr1:43419091 A/T cg03128534 chr1:43423976 SLC2A1 0.56 6.51 0.37 3.75e-10 Red cell distribution width; CESC cis rs8062405 1.000 rs72793811 chr16:28839392 G/A cg05966235 chr16:28915196 ATP2A1 0.35 5.12 0.3 5.8e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs11750568 1.000 rs931617 chr5:178514893 A/C cg10208897 chr5:178548229 ADAMTS2 0.38 5.34 0.31 2.02e-7 Height; CESC cis rs9457247 0.602 rs4710175 chr6:167467800 A/G cg07741184 chr6:167504864 NA 0.37 6.37 0.36 8.32e-10 Crohn's disease; CESC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg13647721 chr17:30228624 UTP6 -0.61 -5.68 -0.33 3.47e-8 Hip circumference adjusted for BMI; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg20488697 chr17:79885644 LOC92659;MAFG 0.48 6.26 0.36 1.56e-9 Systemic lupus erythematosus; CESC cis rs34779708 0.931 rs7079498 chr10:35375344 C/T cg04310649 chr10:35416472 CREM -0.52 -6.42 -0.37 6.25e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg18850127 chr7:39170497 POU6F2 0.39 5.51 0.32 8.38e-8 IgG glycosylation; CESC cis rs6540556 0.723 rs11119336 chr1:209930585 G/C cg05527609 chr1:210001259 C1orf107 -0.67 -7.91 -0.44 7.01e-14 Red blood cell count; CESC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg18337363 chr3:52569053 NT5DC2 0.3 5.17 0.3 4.59e-7 Bipolar disorder; CESC cis rs1008375 1.000 rs11722037 chr4:17683811 G/A cg02297831 chr4:17616191 MED28 0.43 5.58 0.32 5.94e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9287719 0.870 rs728135 chr2:10745132 A/C cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC cis rs5753618 0.504 rs8138525 chr22:32011929 T/C cg02404636 chr22:31891804 SFI1 -0.42 -5.55 -0.32 6.77e-8 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08140891 chr1:154955627 FLAD1 0.61 7.45 0.42 1.35e-12 Gut microbiome composition (summer); CESC cis rs9457247 1.000 rs1794693 chr6:167405670 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.89 0.34 1.15e-8 Crohn's disease; CESC cis rs12142240 0.698 rs1057533 chr1:46815836 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs1009170 0.718 rs7152335 chr14:92590839 T/C cg10324096 chr14:92587714 CPSF2;NDUFB1 0.54 5.1 0.3 6.61e-7 Dialysis-related mortality; CESC cis rs1499972 0.941 rs55958116 chr3:117672772 C/T cg07612923 chr3:117604196 NA 0.89 7.41 0.41 1.71e-12 Schizophrenia; CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg18538332 chr22:24372958 LOC391322 -0.78 -11.51 -0.58 3.97e-25 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg17644776 chr2:200775616 C2orf69 0.52 6.36 0.36 8.92e-10 Osteoporosis; CESC cis rs950776 0.593 rs680244 chr15:78871288 T/C cg24631222 chr15:78858424 CHRNA5 0.44 5.61 0.33 5.17e-8 Sudden cardiac arrest; CESC cis rs7809950 0.817 rs2253833 chr7:107205669 A/G cg23024343 chr7:107201750 COG5 0.56 7.22 0.41 5.59e-12 Coronary artery disease; CESC cis rs7107174 0.901 rs11237459 chr11:78056273 A/C cg02023728 chr11:77925099 USP35 0.4 5.79 0.34 2e-8 Testicular germ cell tumor; CESC cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg05340658 chr4:99064831 C4orf37 0.59 7.9 0.44 7.64e-14 Colonoscopy-negative controls vs population controls; CESC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg05564831 chr3:52568323 NT5DC2 0.47 7.43 0.42 1.48e-12 Electroencephalogram traits; CESC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg22800045 chr5:56110881 MAP3K1 0.79 9.7 0.51 3.11e-19 Initial pursuit acceleration; CESC cis rs13223928 0.516 rs1872880 chr7:3148389 G/C cg19214707 chr7:3157722 NA -0.45 -6.15 -0.35 2.77e-9 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg20887711 chr4:1340912 KIAA1530 0.86 11.47 0.58 5.29e-25 Longevity; CESC trans rs11098499 0.863 rs9884402 chr4:120489982 A/G cg25214090 chr10:38739885 LOC399744 0.64 8.69 0.47 3.86e-16 Corneal astigmatism; CESC cis rs11255291 0.668 rs6602265 chr10:7732939 A/G cg26051552 chr10:7670683 ITIH5 0.37 5.24 0.31 3.28e-7 Ovarian reserve; CESC cis rs2228479 0.867 rs17784386 chr16:89947457 A/G cg06558623 chr16:89946397 TCF25 1.06 8.98 0.48 5.17e-17 Skin colour saturation; CESC cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg10578991 chr7:12443926 VWDE -0.51 -5.67 -0.33 3.75e-8 Coronary artery disease; CESC cis rs478304 0.593 rs4645927 chr11:65482827 C/T cg27068330 chr11:65405492 SIPA1 -0.47 -5.51 -0.32 8.36e-8 Acne (severe); CESC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 9.91 0.52 6.77e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs931812 0.757 rs4734492 chr8:101901901 C/T cg20993868 chr7:22813445 NA -0.44 -6.85 -0.39 5.16e-11 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 7.1 0.4 1.17e-11 Lymphocyte counts; CESC cis rs6011002 1.000 rs75451331 chr20:62316834 G/T cg15212369 chr20:62274085 STMN3 -0.59 -5.15 -0.3 5.18e-7 Dental caries; CESC cis rs6456156 0.586 rs12213683 chr6:167460718 G/A cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.2e-10 Primary biliary cholangitis; CESC cis rs12497850 0.931 rs3774628 chr3:48801840 C/T cg07636037 chr3:49044803 WDR6 0.96 17.3 0.73 2.1e-45 Parkinson's disease; CESC cis rs12325245 0.536 rs12925676 chr16:58625326 C/T cg01152986 chr16:58549298 SETD6 0.86 5.07 0.3 7.48e-7 Schizophrenia; CESC cis rs10927875 0.632 rs4481843 chr1:16128205 G/A cg21385522 chr1:16154831 NA -1.03 -16.84 -0.72 9.42e-44 Dilated cardiomyopathy; CESC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg23281280 chr6:28129359 ZNF389 0.6 7.95 0.44 5.53e-14 Depression; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20811730 chr1:150293902 PRPF3 -0.47 -6.25 -0.36 1.59e-9 Fibrinogen levels; CESC cis rs9837602 0.529 rs793458 chr3:99520169 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.62 -9.72 -0.51 2.66e-19 Breast cancer; CESC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.89e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs4481887 1.000 rs4360553 chr1:248467092 A/G cg00666640 chr1:248458726 OR2T12 0.4 6.54 0.37 3.2e-10 Common traits (Other); CESC cis rs17253792 0.822 rs10148122 chr14:56146694 G/T cg01858014 chr14:56050164 KTN1 -0.94 -7.57 -0.42 6.2800000000000005e-13 Putamen volume; CESC cis rs6674176 0.935 rs4314918 chr1:44377503 G/A cg23954153 chr1:44402353 ARTN -0.35 -5.05 -0.3 8.42e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9325144 0.600 rs7965877 chr12:38743697 G/T cg26384229 chr12:38710491 ALG10B 0.56 8.07 0.44 2.52e-14 Morning vs. evening chronotype; CESC trans rs4332037 0.707 rs62435132 chr7:1891315 C/T cg11693508 chr17:37793320 STARD3 0.61 6.18 0.35 2.45e-9 Bipolar disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20372048 chr12:82752172 CCDC59;C12orf26 -0.46 -6.03 -0.35 5.44e-9 Asthma; CESC cis rs2228479 0.850 rs11647174 chr16:89958538 G/A cg00800038 chr16:89945340 TCF25 -0.94 -7.87 -0.44 9.24e-14 Skin colour saturation; CESC cis rs9388451 0.839 rs3966775 chr6:126067655 C/A cg05901451 chr6:126070800 HEY2 -0.64 -9.14 -0.49 1.69e-17 Brugada syndrome; CESC cis rs9486719 0.656 rs6924957 chr6:96853579 G/T cg06623918 chr6:96969491 KIAA0776 0.76 8.91 0.48 8.52e-17 Migraine;Coronary artery disease; CESC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg18350739 chr11:68623251 NA -0.46 -7.02 -0.4 1.88e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07216194 chr8:27182965 PTK2B -0.48 -6.23 -0.36 1.79e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs698833 0.892 rs698796 chr2:44689669 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 6.11 0.35 3.56e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs854765 0.647 rs7211714 chr17:17986955 A/G cg16928487 chr17:17741425 SREBF1 -0.55 -8.99 -0.48 4.8e-17 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08844988 chr16:24741147 TNRC6A 0.54 6.62 0.38 1.98e-10 Gut microbiome composition (summer); CESC cis rs7100689 0.784 rs4934083 chr10:82116501 G/C cg00277334 chr10:82204260 NA -0.59 -7.34 -0.41 2.65e-12 Post bronchodilator FEV1; CESC cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg13175981 chr1:150552382 MCL1 0.72 10.66 0.55 2.52e-22 Tonsillectomy; CESC cis rs909002 0.720 rs4949459 chr1:32142354 G/T cg13919466 chr1:32135498 COL16A1 -0.39 -6.71 -0.38 1.17e-10 Intelligence (multi-trait analysis); CESC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg02269571 chr22:50332266 NA -0.54 -6.58 -0.37 2.44e-10 Schizophrenia; CESC cis rs684232 0.602 rs4968057 chr17:517521 T/A cg15660573 chr17:549704 VPS53 -0.81 -11.88 -0.59 2.24e-26 Prostate cancer; CESC cis rs11166927 0.548 rs9324514 chr8:140830241 A/G cg16909799 chr8:140841666 TRAPPC9 0.63 9.9 0.52 7.29e-20 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs116095464 0.558 rs56342538 chr5:225796 T/C cg22857025 chr5:266934 NA -1.27 -18.88 -0.76 5.63e-51 Breast cancer; CESC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg11890956 chr21:40555474 PSMG1 1.17 23.27 0.82 5.24e-66 Cognitive function; CESC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg08859206 chr1:53392774 SCP2 -0.49 -6.31 -0.36 1.19e-9 Monocyte count; CESC cis rs1003719 0.667 rs6517404 chr21:38494918 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.52 6.89 0.39 4.09e-11 Eye color traits; CESC cis rs2777491 1.000 rs2730055 chr15:41735708 C/A cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.98 -0.52 4.09e-20 Ulcerative colitis; CESC trans rs801193 1.000 rs2659912 chr7:66157999 G/C cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.21e-16 Aortic root size; CESC cis rs7772486 0.875 rs10872583 chr6:146396699 G/T cg05347473 chr6:146136440 FBXO30 -0.52 -6.75 -0.38 9.11e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs1005277 0.579 rs1740737 chr10:38499365 G/T cg27523141 chr10:43048294 ZNF37B 0.46 6.04 0.35 5.31e-9 Extrinsic epigenetic age acceleration; CESC cis rs3762637 1.000 rs9843165 chr3:122131111 G/C cg24169773 chr3:122142474 KPNA1 -0.5 -6.02 -0.35 5.76e-9 LDL cholesterol levels; CESC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg03146154 chr1:46216737 IPP -0.44 -5.5 -0.32 9.01e-8 High light scatter reticulocyte count; CESC cis rs4955124 0.558 rs17028710 chr3:32037880 T/C cg05935571 chr3:32023257 ZNF860;OSBPL10 0.96 7.02 0.4 1.91e-11 Schizophrenia; CESC cis rs7208859 0.524 rs8069400 chr17:29075967 G/T cg14008862 chr17:28927542 LRRC37B2 0.68 5.45 0.32 1.14e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg05313129 chr8:58192883 C8orf71 -0.53 -6.1 -0.35 3.81e-9 Developmental language disorder (linguistic errors); CESC cis rs7264396 0.832 rs224381 chr20:34097136 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -5.05 -0.3 8.18e-7 Total cholesterol levels; CESC cis rs12586317 0.511 rs113770696 chr14:35444383 C/T cg16230307 chr14:35515116 FAM177A1 0.96 10.66 0.55 2.55e-22 Psoriasis; CESC cis rs561341 1.000 rs546519 chr17:30297682 T/G cg19193384 chr17:30244184 NA -0.61 -6.41 -0.37 6.51e-10 Hip circumference adjusted for BMI; CESC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg18032046 chr6:28092343 ZSCAN16 0.47 5.36 0.31 1.77e-7 Parkinson's disease; CESC cis rs12618769 0.652 rs7588254 chr2:99217785 G/T cg10123293 chr2:99228465 UNC50 0.38 5.06 0.3 7.85e-7 Bipolar disorder; CESC cis rs4555082 1.000 rs7146683 chr14:105759385 A/G cg13114125 chr14:105738426 BRF1 -0.72 -9.25 -0.49 7.83e-18 Mean platelet volume;Platelet distribution width; CESC cis rs9309473 1.000 rs7576245 chr2:73829678 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -6.32 -0.36 1.11e-9 Metabolite levels; CESC cis rs6922893 1.000 rs6900011 chr6:71667550 C/G cg10766373 chr6:71666121 B3GAT2 -0.32 -5.09 -0.3 6.83e-7 Obesity-related traits; CESC cis rs7843479 0.965 rs11135742 chr8:21802910 A/T cg17168535 chr8:21777572 XPO7 0.5 6.9 0.39 3.73e-11 Mean corpuscular volume; CESC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.58 -8.42 -0.46 2.36e-15 Bipolar disorder; CESC cis rs16854884 0.558 rs6768153 chr3:143667429 C/A cg06585982 chr3:143692056 C3orf58 0.55 7.37 0.41 2.13e-12 Economic and political preferences (feminism/equality); CESC cis rs329122 0.528 rs329117 chr5:133860101 T/C cg26284174 chr5:133860141 NA 0.47 5.49 0.32 9.57e-8 Body mass index;Type 2 diabetes; CESC cis rs7834588 0.526 rs7008796 chr8:63866789 C/A cg20602954 chr8:63776762 NKAIN3 0.32 5.03 0.3 9.22e-7 Response to Vitamin E supplementation; CESC trans rs2832077 0.527 rs9980449 chr21:30224889 G/C cg14791747 chr16:20752902 THUMPD1 0.53 7.48 0.42 1.12e-12 Cognitive test performance; CESC cis rs9837602 0.551 rs1630555 chr3:99423273 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -5.27 -0.31 2.86e-7 Breast cancer; CESC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg18301423 chr5:131593218 PDLIM4 0.39 5.5 0.32 8.96e-8 Breast cancer; CESC cis rs12458462 0.892 rs2007483 chr18:77476131 A/T cg11879182 chr18:77439856 CTDP1 0.87 13.84 0.65 3.9e-33 Monocyte count; CESC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 11.28 0.57 2.4e-24 Platelet count; CESC cis rs367943 0.637 rs10039956 chr5:113010928 G/A cg12552261 chr5:112820674 MCC 0.48 5.74 0.33 2.54e-8 Type 2 diabetes; CESC cis rs2085601 0.509 rs1458558 chr4:89887620 C/T cg17769793 chr4:89976368 FAM13A -0.35 -5.65 -0.33 4.04e-8 Hair greying; CESC cis rs34779708 0.931 rs7099036 chr10:35349574 C/T cg04310649 chr10:35416472 CREM -0.52 -6.25 -0.36 1.65e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs6570726 0.967 rs441364 chr6:145853662 G/C cg05347473 chr6:146136440 FBXO30 0.4 5.2 0.3 4.08e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs1707322 1.000 rs785490 chr1:46577124 T/C cg06784218 chr1:46089804 CCDC17 -0.36 -5.93 -0.34 9.35e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11958404 0.932 rs12514557 chr5:157418954 T/C cg05962755 chr5:157440814 NA 0.62 6.72 0.38 1.08e-10 IgG glycosylation; CESC trans rs1814175 0.587 rs7937757 chr11:49978342 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs7680126 0.530 rs2903827 chr4:10175872 C/G cg00071950 chr4:10020882 SLC2A9 -0.52 -5.94 -0.34 8.79e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg25072359 chr17:41440525 NA 0.5 6.47 0.37 4.61e-10 Menopause (age at onset); CESC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg04025307 chr7:1156635 C7orf50 0.57 10.24 0.53 5.83e-21 Longevity;Endometriosis; CESC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.05 -0.35 5.02e-9 Depression; CESC cis rs11227306 0.902 rs625652 chr11:65641931 T/A cg00576331 chr11:65640516 EFEMP2 0.47 6.04 0.35 5.18e-9 DNA methylation (variation); CESC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg06108461 chr20:60628389 TAF4 -0.92 -14.32 -0.66 7.92e-35 Body mass index; CESC cis rs847577 0.569 rs35101190 chr7:97695888 G/A cg21770322 chr7:97807741 LMTK2 0.82 14.59 0.67 8.56e-36 Breast cancer; CESC cis rs9325144 0.647 rs1875609 chr12:39018259 C/T cg26384229 chr12:38710491 ALG10B -0.54 -7.57 -0.42 6.4e-13 Morning vs. evening chronotype; CESC cis rs9929218 0.906 rs4783565 chr16:68750190 G/A cg02972257 chr16:68554789 NA 0.58 6.67 0.38 1.5e-10 Colorectal cancer; CESC cis rs6951245 0.810 rs117800627 chr7:1081075 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.79 0.38 7.38e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg22903471 chr2:27725779 GCKR -0.55 -7.77 -0.43 1.69e-13 Total body bone mineral density; CESC cis rs9905704 0.633 rs2632506 chr17:56467408 G/T cg12560992 chr17:57184187 TRIM37 -0.61 -5.75 -0.33 2.49e-8 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02546072 chr22:39898416 SMCR7L 0.56 6.33 0.36 1.04e-9 Gut microbiome composition (summer); CESC cis rs2191566 0.960 rs56171514 chr19:44506110 G/C cg20607764 chr19:44506953 ZNF230 -0.51 -6.56 -0.37 2.82e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg19723775 chr5:179050963 HNRNPH1 0.44 5.91 0.34 1.03e-8 Lung cancer; CESC cis rs1707322 0.927 rs6690386 chr1:46253011 C/T cg05343316 chr1:45956843 TESK2 0.49 6.05 0.35 4.99e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.35 0.5 3.83e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs11098499 0.754 rs1814813 chr4:120258207 G/T cg09307838 chr4:120376055 NA -0.77 -10.94 -0.56 3.23e-23 Corneal astigmatism; CESC cis rs868036 1.000 rs1026734 chr15:68100950 T/C cg08079166 chr15:68083412 MAP2K5 0.44 6.94 0.39 2.94e-11 Restless legs syndrome; CESC cis rs7927771 1.000 rs7120333 chr11:47817441 C/T cg18512352 chr11:47633146 NA -0.6 -9.57 -0.51 8.16e-19 Subjective well-being; CESC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs67311347 1.000 rs9882171 chr3:40518821 G/A cg01475735 chr3:40494733 NA -0.42 -5.41 -0.32 1.38e-7 Renal cell carcinoma; CESC cis rs9457247 0.967 rs388406 chr6:167409562 A/G cg23791538 chr6:167370224 RNASET2 -0.61 -8.81 -0.48 1.62e-16 Crohn's disease; CESC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg07677032 chr17:61819896 STRADA 0.46 6.21 0.36 2.06e-9 Prudent dietary pattern; CESC cis rs3820068 0.626 rs61103742 chr1:15909153 A/C cg17385448 chr1:15911702 AGMAT 0.42 6.66 0.38 1.6e-10 Systolic blood pressure; CESC cis rs7949030 0.596 rs11231137 chr11:62315699 G/A cg02375832 chr11:62437615 C11orf48 -0.39 -5.46 -0.32 1.08e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs919433 0.963 rs12693815 chr2:198168403 T/C cg03934865 chr2:198174659 NA -0.4 -5.54 -0.32 7.21e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg13395646 chr4:1353034 KIAA1530 -0.4 -5.26 -0.31 3.01e-7 Longevity; CESC cis rs4561483 0.549 rs33659 chr16:11963361 A/G cg08843971 chr16:11963173 GSPT1 -0.55 -7.95 -0.44 5.25e-14 Testicular germ cell tumor; CESC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg11211951 chr8:145729740 GPT 0.42 6.94 0.39 3.07e-11 Age at first birth; CESC cis rs17253792 0.822 rs79747476 chr14:56160485 C/A cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.67 0.33 3.65e-8 Putamen volume; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg20118422 chr15:64455210 PPIB -0.47 -6.1 -0.35 3.81e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16060664 chr8:42010866 AP3M2 0.54 6.2 0.36 2.15e-9 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.01 0.4 2e-11 Bipolar disorder; CESC cis rs7927771 0.524 rs12421563 chr11:47780222 G/A cg05585544 chr11:47624801 NA -0.32 -5.11 -0.3 6.09e-7 Subjective well-being; CESC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg07507251 chr3:52567010 NT5DC2 0.32 5.54 0.32 7.3e-8 Bipolar disorder; CESC cis rs2637266 1.000 rs7478008 chr10:78355575 T/A cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs16857609 0.564 rs12624106 chr2:218290445 A/G cg15335768 chr2:218268053 DIRC3 -0.38 -5.34 -0.31 1.96e-7 Breast cancer;Breast cancer (estrogen-receptor negative); CESC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg14820908 chr5:178986412 RUFY1 -0.5 -7.8 -0.43 1.43e-13 Lung cancer; CESC cis rs826838 0.874 rs10880943 chr12:38734317 C/T cg13010199 chr12:38710504 ALG10B 0.62 8.9 0.48 8.97e-17 Heart rate; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg17372223 chr3:52568218 NT5DC2 0.45 7.54 0.42 7.38e-13 Bipolar disorder; CESC cis rs208520 0.770 rs1342960 chr6:66883514 T/C cg07460842 chr6:66804631 NA -0.94 -12.15 -0.6 2.75e-27 Exhaled nitric oxide output; CESC cis rs9611565 0.608 rs202652 chr22:41838792 A/G cg06481639 chr22:41940642 POLR3H 0.52 5.68 0.33 3.48e-8 Vitiligo; CESC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg05863683 chr7:1912471 MAD1L1 0.38 5.64 0.33 4.43e-8 Bipolar disorder and schizophrenia; CESC cis rs2296225 0.722 rs900037 chr1:21057788 C/T cg24673385 chr1:21051448 SH2D5 0.35 5.65 0.33 4.13e-8 Eosinophilic esophagitis; CESC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg00310523 chr12:86230176 RASSF9 0.37 5.65 0.33 4.22e-8 Major depressive disorder; CESC cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg11952622 chr19:58962976 ZNF324B 0.52 6.93 0.39 3.12e-11 Uric acid clearance; CESC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg08859206 chr1:53392774 SCP2 0.54 7.12 0.4 1.03e-11 Monocyte count; CESC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10857712 0.703 rs1056521 chr10:135235890 T/C cg01444801 chr10:135216882 MTG1 -0.46 -5.26 -0.31 2.91e-7 Systemic lupus erythematosus; CESC cis rs8014204 0.935 rs4903267 chr14:75360419 G/T cg26191576 chr14:75389716 RPS6KL1 0.36 5.17 0.3 4.61e-7 Caffeine consumption; CESC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg12463550 chr7:65579703 CRCP -0.49 -6.21 -0.36 2.06e-9 Aortic root size; CESC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg01448562 chr3:133502909 NA 0.4 5.56 0.32 6.52e-8 Iron status biomarkers; CESC cis rs72945132 0.825 rs57871058 chr11:70192344 T/C cg14191688 chr11:70257035 CTTN 0.4 5.05 0.3 8.13e-7 Coronary artery disease; CESC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg26769984 chr7:1090371 C7orf50 0.53 6.37 0.36 8.49e-10 Bronchopulmonary dysplasia; CESC cis rs4450798 0.793 rs79204004 chr3:13758473 G/C cg23332027 chr3:13681764 NA 0.4 5.55 0.32 6.83e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.26 0.31 3e-7 Menopause (age at onset); CESC cis rs7429990 0.965 rs28637561 chr3:48021018 G/A cg11946769 chr3:48343235 NME6 -0.44 -5.38 -0.31 1.65e-7 Educational attainment (years of education); CESC cis rs12545109 0.879 rs2609994 chr8:57365844 A/G cg09654669 chr8:57350985 NA -0.57 -6.67 -0.38 1.46e-10 Obesity-related traits; CESC cis rs7193541 0.684 rs9931225 chr16:74699293 T/C cg01733217 chr16:74700730 RFWD3 1.08 22.1 0.81 4.71e-62 Multiple myeloma; CESC cis rs4835473 0.932 rs11725708 chr4:144696836 T/C cg25736465 chr4:144833511 NA -0.33 -5.18 -0.3 4.39e-7 Immature fraction of reticulocytes; CESC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.45 -5.76 -0.33 2.32e-8 Bipolar disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12112058 chr1:224622605 WDR26 -0.47 -6.86 -0.39 4.89e-11 Gambling; CESC cis rs67311347 0.955 rs11719205 chr3:40417258 G/A cg24209194 chr3:40518798 ZNF619 0.44 5.82 0.34 1.72e-8 Renal cell carcinoma; CESC cis rs35306767 0.953 rs7908138 chr10:962978 C/T cg25019033 chr10:957182 NA -0.67 -8.16 -0.45 1.4e-14 Eosinophil percentage of granulocytes; CESC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.58 0.32 5.93e-8 Bipolar disorder; CESC cis rs8020095 0.528 rs28521373 chr14:67738075 T/C cg19548862 chr14:67692701 FAM71D -0.45 -5.44 -0.32 1.2e-7 Depression (quantitative trait); CESC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 11.76 0.59 5.69e-26 Platelet count; CESC cis rs8060686 0.623 rs6499157 chr16:68105474 A/C cg26727032 chr16:67993705 SLC12A4 -0.6 -8.9 -0.48 8.84e-17 HDL cholesterol;Metabolic syndrome; CESC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg21984481 chr17:79567631 NPLOC4 -0.35 -5.34 -0.31 1.97e-7 Eye color traits; CESC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg15664640 chr17:80829946 TBCD -0.67 -9.43 -0.5 2.15e-18 Breast cancer; CESC cis rs7674212 0.570 rs2711899 chr4:104062414 T/C cg16532752 chr4:104119610 CENPE -0.38 -5.1 -0.3 6.54e-7 Type 2 diabetes; CESC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg10691866 chr7:65817282 TPST1 -0.3 -5.17 -0.3 4.54e-7 Aortic root size; CESC cis rs763121 0.853 rs138704 chr22:39133410 A/G cg06544989 chr22:39130855 UNC84B 0.49 9.04 0.49 3.36e-17 Menopause (age at onset); CESC cis rs11711311 1.000 rs9855613 chr3:113448455 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.57 7.68 0.43 3.09e-13 IgG glycosylation; CESC cis rs4722166 0.598 rs4722171 chr7:22785717 A/G cg05265849 chr7:22767390 IL6 0.57 7.08 0.4 1.31e-11 Lung cancer; CESC cis rs10791097 0.694 rs10791100 chr11:130738946 T/A cg12179176 chr11:130786555 SNX19 0.64 10.04 0.52 2.69e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs3960554 0.808 rs111714534 chr7:75748896 C/T cg17325771 chr7:75508891 RHBDD2 -0.36 -5.2 -0.3 3.98e-7 Eotaxin levels; CESC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg20243544 chr17:37824526 PNMT -0.49 -5.92 -0.34 1.01e-8 Glomerular filtration rate (creatinine); CESC cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg03709012 chr19:19516395 GATAD2A 1.01 15.7 0.69 1.01e-39 Tonsillectomy; CESC cis rs7084402 0.967 rs7100474 chr10:60273121 T/C cg07615347 chr10:60278583 BICC1 -0.57 -8.84 -0.48 1.41e-16 Refractive error; CESC cis rs1008375 1.000 rs55939327 chr4:17642937 T/A cg16339924 chr4:17578868 LAP3 0.56 7.02 0.4 1.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC trans rs1814175 0.617 rs6486020 chr11:49769149 T/G cg11707556 chr5:10655725 ANKRD33B -0.42 -6.06 -0.35 4.69e-9 Height; CESC trans rs9467711 0.659 rs3734542 chr6:26468326 G/A cg06606381 chr12:133084897 FBRSL1 -0.95 -7.48 -0.42 1.07e-12 Autism spectrum disorder or schizophrenia; CESC cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.49 -6.44 -0.37 5.49e-10 Personality dimensions; CESC cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg20891283 chr12:69753455 YEATS4 0.75 11.2 0.57 4.14e-24 Blood protein levels; CESC cis rs2228479 0.717 rs34027607 chr16:89808939 T/C cg06558623 chr16:89946397 TCF25 0.79 7.45 0.42 1.32e-12 Skin colour saturation; CESC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg12463550 chr7:65579703 CRCP 0.58 7.41 0.41 1.67e-12 Aortic root size; CESC cis rs17253792 0.822 rs76205307 chr14:56166038 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs6691722 0.503 rs7546875 chr1:24703667 T/C cg02336364 chr1:24764700 NIPAL3 0.33 6.82 0.39 6.06e-11 Response to interferon beta in multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02438591 chr16:2205559 TRAF7;SNORD60 0.6 6.94 0.39 2.95e-11 Gut microbiome composition (summer); CESC cis rs9322193 0.884 rs880245 chr6:150167398 A/G cg09699651 chr6:150184138 LRP11 -0.45 -5.47 -0.32 1.05e-7 Lung cancer; CESC cis rs7312933 0.592 rs1551210 chr12:42865874 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.17 0.35 2.61e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg02487422 chr3:49467188 NICN1 0.45 5.67 0.33 3.69e-8 Parkinson's disease; CESC cis rs1538970 0.961 rs7553318 chr1:45843086 A/G cg06784218 chr1:46089804 CCDC17 0.34 5.71 0.33 2.98e-8 Platelet count; CESC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg06873352 chr17:61820015 STRADA 0.48 7.04 0.4 1.63e-11 Height; CESC cis rs2239547 0.522 rs4519686 chr3:52997871 C/T cg11645453 chr3:52864694 ITIH4 0.32 5.7 0.33 3.16e-8 Schizophrenia; CESC cis rs9863 0.828 rs12833624 chr12:124476873 C/T cg17562584 chr12:124393655 DNAH10 0.32 5.49 0.32 9.37e-8 White blood cell count; CESC cis rs9322193 0.651 rs9322188 chr6:149909491 A/G cg13206674 chr6:150067644 NUP43 -0.4 -5.72 -0.33 2.87e-8 Lung cancer; CESC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg24154853 chr7:158122151 PTPRN2 0.43 6.78 0.38 7.65e-11 Calcium levels; CESC cis rs11958404 0.615 rs10044900 chr5:157451580 C/T cg05962755 chr5:157440814 NA -0.38 -5.85 -0.34 1.43e-8 IgG glycosylation; CESC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg08859206 chr1:53392774 SCP2 0.53 7.09 0.4 1.19e-11 Monocyte count; CESC cis rs3096299 0.934 rs9927904 chr16:89462847 G/A cg02187348 chr16:89574699 SPG7 0.51 6.74 0.38 1.01e-10 Multiple myeloma (IgH translocation); CESC cis rs11098499 0.863 rs13134665 chr4:120426430 T/C cg24375607 chr4:120327624 NA 0.43 5.11 0.3 6.08e-7 Corneal astigmatism; CESC cis rs3784262 1.000 rs4646619 chr15:58258342 A/G cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.11 -0.3 6.15e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22350171 chr1:228675139 RNF187 0.57 6.38 0.36 7.71e-10 Gut microbiome composition (summer); CESC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg26335602 chr6:28129616 ZNF389 0.44 5.66 0.33 3.97e-8 Parkinson's disease; CESC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg25072359 chr17:41440525 NA 0.5 6.46 0.37 4.89e-10 Menopause (age at onset); CESC cis rs7945705 0.967 rs34842234 chr11:8891894 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.36 5.85 0.34 1.48e-8 Hemoglobin concentration; CESC cis rs2635047 0.935 rs2635050 chr18:44664131 G/A cg19077165 chr18:44547161 KATNAL2 -0.43 -5.85 -0.34 1.47e-8 Educational attainment; CESC cis rs2522056 1.000 rs757105 chr5:131795663 C/T cg24060327 chr5:131705240 SLC22A5 0.59 6.63 0.38 1.85e-10 Lymphocyte counts;Fibrinogen; CESC cis rs2120019 1.000 rs12901243 chr15:75374233 C/T cg09165964 chr15:75287851 SCAMP5 -0.67 -8.12 -0.45 1.76e-14 Blood trace element (Zn levels); CESC trans rs1814175 0.715 rs1722007 chr11:49897319 T/C cg15704280 chr7:45808275 SEPT13 -1.02 -19.96 -0.77 9.67e-55 Height; CESC cis rs68170813 0.641 rs4730228 chr7:106904077 T/C cg02696742 chr7:106810147 HBP1 -0.52 -5.09 -0.3 6.84e-7 Coronary artery disease; CESC cis rs34526934 0.608 rs2857539 chr2:177024863 G/A cg14324370 chr2:177042789 NA -0.49 -5.9 -0.34 1.1e-8 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs453301 0.571 rs2929456 chr8:9083416 G/A cg15556689 chr8:8085844 FLJ10661 -0.53 -6.61 -0.38 2.14e-10 Joint mobility (Beighton score); CESC cis rs4253772 0.591 rs6007740 chr22:46654323 A/G cg24881330 chr22:46731750 TRMU -0.87 -10.17 -0.53 1.02e-20 LDL cholesterol;Cholesterol, total; CESC cis rs13256369 0.826 rs7846050 chr8:8575669 A/G cg17143192 chr8:8559678 CLDN23 0.73 8.88 0.48 1.04e-16 Obesity-related traits; CESC cis rs7580658 0.963 rs12463451 chr2:128053883 C/T cg10021288 chr2:128175891 PROC -0.41 -6.55 -0.37 3.06e-10 Protein C levels; CESC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg15605315 chr1:45957053 TESK2 0.43 5.36 0.31 1.82e-7 High light scatter reticulocyte count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05409038 chr2:71221890 TEX261 0.48 6.03 0.35 5.6e-9 Gut microbiota (bacterial taxa); CESC trans rs9314308 0.609 rs4872343 chr8:25547166 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.47 -6.0 -0.35 6.6e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2120019 1.000 rs12903201 chr15:75370776 A/C cg09165964 chr15:75287851 SCAMP5 -0.67 -8.12 -0.45 1.76e-14 Blood trace element (Zn levels); CESC cis rs2011503 0.882 rs10407933 chr19:19364319 A/G cg11584989 chr19:19387371 SF4 0.53 6.41 0.37 6.52e-10 Bipolar disorder; CESC cis rs6459788 0.585 rs6950818 chr7:157235364 C/G cg03453431 chr7:157225567 NA -0.39 -6.68 -0.38 1.44e-10 Epstein-Barr virus copy number in lymphoblastoid cell lines; CESC trans rs4716602 0.596 rs10265909 chr7:156158095 T/C cg07175507 chr18:77160758 NFATC1 -0.45 -6.14 -0.35 3e-9 Anti-saccade response; CESC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC trans rs11098499 0.754 rs10213267 chr4:120239074 A/G cg25214090 chr10:38739885 LOC399744 0.61 8.51 0.46 1.33e-15 Corneal astigmatism; CESC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg13393036 chr8:95962371 TP53INP1 -0.49 -10.52 -0.54 7.38e-22 Type 2 diabetes; CESC cis rs7394190 0.748 rs16930909 chr10:75561582 T/C cg07699608 chr10:75541558 CHCHD1 0.62 5.13 0.3 5.57e-7 Incident atrial fibrillation; CESC cis rs617791 0.530 rs10791835 chr11:65750924 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.45 -5.1 -0.3 6.36e-7 Breast cancer; CESC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg11764359 chr7:65958608 NA -0.92 -14.57 -0.67 9.81e-36 Aortic root size; CESC cis rs12586317 0.513 rs17102962 chr14:35478782 A/T cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC cis rs6912958 0.781 rs6454632 chr6:88231824 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -5.62 -0.33 4.79e-8 Monocyte percentage of white cells; CESC cis rs9487051 0.676 rs1829694 chr6:109593860 G/T cg12927641 chr6:109611667 NA -0.37 -5.56 -0.32 6.55e-8 Reticulocyte fraction of red cells; CESC cis rs6831352 0.918 rs4699712 chr4:100060490 A/T cg13256891 chr4:100009986 ADH5 -0.75 -8.21 -0.45 9.89e-15 Alcohol dependence; CESC cis rs3820928 0.775 rs10179756 chr2:227897076 A/G cg05526886 chr2:227700861 RHBDD1 -0.45 -5.68 -0.33 3.55e-8 Pulmonary function; CESC cis rs62064224 0.614 rs8065246 chr17:30682274 T/C cg18200150 chr17:30822561 MYO1D 0.39 5.17 0.3 4.71e-7 Schizophrenia; CESC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg21984481 chr17:79567631 NPLOC4 0.49 8.04 0.44 2.97e-14 Eye color traits; CESC cis rs62064224 0.714 rs16967266 chr17:30632274 G/A cg18200150 chr17:30822561 MYO1D 0.39 5.21 0.3 3.87e-7 Schizophrenia; CESC cis rs763121 0.889 rs1837988 chr22:38901094 A/G cg06022373 chr22:39101656 GTPBP1 0.78 11.1 0.56 8.93e-24 Menopause (age at onset); CESC cis rs6584283 0.846 rs11190135 chr10:101286848 A/G cg09788492 chr10:101292477 NKX2-3 0.33 6.31 0.36 1.14e-9 Ulcerative colitis; CESC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg13393036 chr8:95962371 TP53INP1 0.47 9.09 0.49 2.33e-17 Type 2 diabetes; CESC cis rs8077577 0.895 rs11654741 chr17:18124470 C/A cg16794390 chr17:18148240 FLII 0.44 5.9 0.34 1.12e-8 Obesity-related traits; CESC cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg02487422 chr3:49467188 NICN1 0.45 5.6 0.33 5.31e-8 Parkinson's disease; CESC cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg08355456 chr11:67383691 NA 0.34 5.22 0.31 3.59e-7 Mean corpuscular volume; CESC cis rs11696501 0.739 rs2281210 chr20:44243172 T/G cg11783356 chr20:44313418 WFDC10B -0.35 -5.35 -0.31 1.87e-7 Brain structure; CESC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg10578991 chr7:12443926 VWDE -0.45 -5.09 -0.3 6.83e-7 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13679837 chr20:21283918 XRN2 -0.47 -6.23 -0.36 1.79e-9 Fibrinogen levels; CESC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg26335602 chr6:28129616 ZNF389 0.49 6.17 0.35 2.6e-9 Parkinson's disease; CESC cis rs3126085 0.935 rs4421596 chr1:152181673 G/A cg26876637 chr1:152193138 HRNR 0.48 5.44 0.32 1.21e-7 Atopic dermatitis; CESC cis rs11148252 0.557 rs9536223 chr13:53233194 A/T cg00495681 chr13:53174319 NA 0.6 8.22 0.45 8.91e-15 Lewy body disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08857039 chr6:42110396 C6orf132 -0.41 -6.14 -0.35 3.09e-9 Fibrinogen levels; CESC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg26818010 chr10:134567672 INPP5A -0.94 -11.42 -0.57 7.62e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs6843777 chr4:98866635 T/A cg05340658 chr4:99064831 C4orf37 0.74 10.69 0.55 2.07e-22 Colonoscopy-negative controls vs population controls; CESC cis rs6582630 0.516 rs12814528 chr12:38296111 G/A cg26384229 chr12:38710491 ALG10B -0.44 -5.7 -0.33 3.17e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs1501138 0.642 rs887648 chr4:16296121 G/A cg02999755 chr11:102963244 DCUN1D5 0.66 6.05 0.35 4.81e-9 Systemic juvenile idiopathic arthritis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg27304813 chr3:120068385 LRRC58 0.48 6.29 0.36 1.27e-9 Systemic lupus erythematosus; CESC cis rs6463523 0.864 rs73047957 chr7:759373 A/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.97 14.68 0.67 4.26e-36 Subjective well-being; CESC cis rs9399135 0.967 rs7741626 chr6:135314182 C/T cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg16325326 chr1:53192061 ZYG11B 0.61 8.92 0.48 8.04e-17 Monocyte count; CESC cis rs761746 0.960 rs1543416 chr22:31925073 A/G cg25791279 chr22:32026902 PISD 0.44 5.38 0.31 1.64e-7 Intelligence; CESC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.36 -5.89 -0.34 1.2e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9486719 0.843 rs3860229 chr6:97036559 T/C cg06623918 chr6:96969491 KIAA0776 -0.88 -10.52 -0.54 7.14e-22 Migraine;Coronary artery disease; CESC cis rs12618769 0.570 rs17032866 chr2:99132415 A/G cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs1669338 0.507 rs4685609 chr3:3202279 T/C cg16797762 chr3:3221439 CRBN -0.63 -6.69 -0.38 1.3100000000000001e-10 White matter integrity; CESC cis rs7568458 0.684 rs7593969 chr2:85809670 A/G cg02493740 chr2:85810744 VAMP5 0.56 8.26 0.45 6.78e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs13064411 0.696 rs1552432 chr3:113225660 G/C cg18753928 chr3:113234510 CCDC52 -0.5 -6.13 -0.35 3.23e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg06074448 chr4:187884817 NA -0.36 -5.12 -0.3 5.96e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9611565 0.659 rs17367849 chr22:41923644 G/A cg17376030 chr22:41985996 PMM1 0.73 8.12 0.45 1.72e-14 Vitiligo; CESC cis rs2075371 0.897 rs12667905 chr7:134000812 A/C cg11752832 chr7:134001865 SLC35B4 0.53 6.84 0.39 5.43e-11 Mean platelet volume; CESC cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.24e-7 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.622 rs9977258 chr21:44976485 G/T cg21573476 chr21:45109991 RRP1B -0.43 -5.91 -0.34 1.08e-8 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03043827 chr4:128981985 LARP1B 0.56 6.16 0.35 2.72e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 4.04e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9814567 0.752 rs13098546 chr3:134333161 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.43 5.56 0.32 6.5e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9858542 0.953 rs7623659 chr3:49414791 C/T cg03060546 chr3:49711283 APEH -0.54 -6.16 -0.35 2.67e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg23281280 chr6:28129359 ZNF389 0.48 6.32 0.36 1.1e-9 Parkinson's disease; CESC cis rs60154123 0.505 rs77990373 chr1:210041111 T/C cg22029157 chr1:209979665 IRF6 0.72 7.16 0.4 8.04e-12 Coronary artery disease; CESC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg16405210 chr4:1374714 KIAA1530 -0.94 -12.63 -0.61 6.31e-29 Longevity; CESC cis rs6460942 0.915 rs62447642 chr7:12489147 T/C cg02935154 chr7:12443704 VWDE -0.57 -5.94 -0.34 9.02e-9 Coronary artery disease; CESC cis rs7605827 0.897 rs1919292 chr2:15567236 A/G cg19274914 chr2:15703543 NA 0.32 5.74 0.33 2.53e-8 Educational attainment (years of education); CESC cis rs863345 0.625 rs7534112 chr1:158532065 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -7.0 -0.4 2.08e-11 Pneumococcal bacteremia; CESC cis rs472109 0.967 rs360153 chr11:9762274 T/C cg03108697 chr11:9732066 SWAP70 -0.36 -5.55 -0.32 6.75e-8 Coronary artery disease; CESC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg02725872 chr8:58115012 NA 0.4 5.62 0.33 4.85e-8 Developmental language disorder (linguistic errors); CESC trans rs561341 1.000 rs55962687 chr17:30260369 C/T cg20587970 chr11:113659929 NA -1.35 -16.55 -0.71 9.41e-43 Hip circumference adjusted for BMI; CESC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg00129232 chr17:37814104 STARD3 0.52 6.68 0.38 1.43e-10 Glomerular filtration rate (creatinine); CESC cis rs7267979 0.789 rs6083820 chr20:25354178 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -11.76 -0.59 5.77e-26 Liver enzyme levels (alkaline phosphatase); CESC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.43e-21 Prudent dietary pattern; CESC cis rs62064224 0.703 rs62065492 chr17:30822607 C/T cg09324608 chr17:30823087 MYO1D 0.5 7.7 0.43 2.73e-13 Schizophrenia; CESC cis rs9303401 0.573 rs34097494 chr17:57171917 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.92 11.49 0.58 4.47e-25 Cognitive test performance; CESC cis rs6484504 0.576 rs208091 chr11:31190099 G/C cg14844989 chr11:31128820 NA -0.43 -6.08 -0.35 4.22e-9 Red blood cell count; CESC cis rs35110281 0.774 rs1378080 chr21:45011315 T/A cg04455712 chr21:45112962 RRP1B 0.38 5.58 0.32 5.93e-8 Mean corpuscular volume; CESC trans rs9467711 0.659 rs36033628 chr6:26456074 T/G cg06606381 chr12:133084897 FBRSL1 -0.94 -6.61 -0.38 2.08e-10 Autism spectrum disorder or schizophrenia; CESC cis rs6500395 0.963 rs961951 chr16:48716720 A/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.51 -0.37 3.67e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7786808 0.615 rs4909212 chr7:158197037 G/T cg09998033 chr7:158218633 PTPRN2 -0.39 -5.66 -0.33 3.99e-8 Obesity-related traits; CESC cis rs10089 1.000 rs4836366 chr5:127482494 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.51 0.54 8.08e-22 Ileal carcinoids; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10756578 chr16:86589063 MTHFSD;FLJ30679 -0.44 -6.09 -0.35 3.86e-9 Gambling; CESC trans rs11039798 1.000 rs34044596 chr11:48527936 T/C cg15704280 chr7:45808275 SEPT13 0.7 6.47 0.37 4.67e-10 Axial length; CESC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg02462569 chr6:150064036 NUP43 -0.35 -5.17 -0.3 4.52e-7 Lung cancer; CESC cis rs12956009 0.559 rs12607072 chr18:44839888 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.49 6.39 0.37 7.52e-10 Educational attainment (years of education); CESC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg07507251 chr3:52567010 NT5DC2 0.42 7.35 0.41 2.48e-12 Bipolar disorder; CESC cis rs4948102 0.691 rs10435504 chr7:56059591 G/C cg09872392 chr7:56161020 PHKG1 -0.46 -7.25 -0.41 4.59e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg07936489 chr17:37558343 FBXL20 -0.78 -11.11 -0.56 8.49e-24 Glomerular filtration rate (creatinine); CESC cis rs4481887 1.000 rs10736378 chr1:248455769 T/G cg00666640 chr1:248458726 OR2T12 0.38 6.35 0.36 9.44e-10 Common traits (Other); CESC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg12311346 chr5:56204834 C5orf35 -0.7 -6.77 -0.38 8.36e-11 Type 2 diabetes; CESC cis rs6121246 0.609 rs6088997 chr20:30289824 A/G cg13852791 chr20:30311386 BCL2L1 -0.77 -9.77 -0.51 1.86e-19 Mean corpuscular hemoglobin; CESC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg18876405 chr7:65276391 NA -0.58 -7.5 -0.42 9.83e-13 Aortic root size; CESC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg18876405 chr7:65276391 NA -0.51 -5.96 -0.34 8.21e-9 Aortic root size; CESC cis rs710216 0.917 rs900834 chr1:43412343 A/G cg22176566 chr1:43424700 SLC2A1 -0.51 -5.62 -0.33 4.72e-8 Red cell distribution width; CESC cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg09658497 chr7:2847517 GNA12 -0.34 -5.22 -0.31 3.53e-7 Height; CESC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg13866156 chr1:1669148 SLC35E2 -0.51 -6.66 -0.38 1.56e-10 Body mass index; CESC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.41 0.32 1.4e-7 Personality dimensions; CESC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg00684032 chr4:1343700 KIAA1530 0.41 5.77 0.33 2.22e-8 Obesity-related traits; CESC cis rs1008375 1.000 rs1121089 chr4:17676476 C/A cg16339924 chr4:17578868 LAP3 0.51 6.44 0.37 5.73e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg10560079 chr2:191398806 TMEM194B -0.49 -7.2 -0.4 6.13e-12 Pulse pressure; CESC cis rs7683537 0.501 rs2171838 chr4:185667404 A/G cg04058563 chr4:185651563 MLF1IP -0.45 -5.23 -0.31 3.4e-7 Systemic lupus erythematosus; CESC cis rs4975616 0.836 rs13178866 chr5:1323212 C/T cg07493874 chr5:1342172 CLPTM1L -0.41 -7.86 -0.43 9.75e-14 Lung cancer; CESC trans rs3942852 0.910 rs10742829 chr11:48115837 C/T cg03929089 chr4:120376271 NA 0.57 6.13 0.35 3.25e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs9487051 0.646 rs11153165 chr6:109622159 G/A cg01475377 chr6:109611718 NA -0.39 -5.39 -0.31 1.55e-7 Reticulocyte fraction of red cells; CESC cis rs9309473 0.519 rs4852950 chr2:73864670 C/T cg20560298 chr2:73613845 ALMS1 0.49 6.86 0.39 4.9e-11 Metabolite levels; CESC cis rs4654899 0.727 rs11805169 chr1:21156862 A/T cg05370193 chr1:21551575 ECE1 -0.36 -5.46 -0.32 1.11e-7 Superior frontal gyrus grey matter volume; CESC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg15352829 chr14:105391018 PLD4 -0.59 -10.35 -0.54 2.66e-21 Rheumatoid arthritis; CESC cis rs4964805 0.657 rs11111783 chr12:104188523 A/G cg02344784 chr12:104178138 NT5DC3 0.47 6.6 0.38 2.19e-10 Attention deficit hyperactivity disorder; CESC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg25072359 chr17:41440525 NA 0.45 6.05 0.35 4.84e-9 Menopause (age at onset); CESC cis rs35110281 0.715 rs2838353 chr21:45119228 C/T cg01579765 chr21:45077557 HSF2BP -0.52 -8.8 -0.48 1.82e-16 Mean corpuscular volume; CESC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg23758822 chr17:41437982 NA 1.03 14.68 0.67 3.99e-36 Menopause (age at onset); CESC cis rs473651 0.935 rs477041 chr2:239355995 C/G cg21699342 chr2:239360505 ASB1 -0.55 -9.26 -0.49 7.29e-18 Multiple system atrophy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22521096 chr17:7518744 FXR2;SHBG 0.47 6.07 0.35 4.38e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1371867 0.846 rs1660351 chr8:101275034 C/T cg11906718 chr8:101322791 RNF19A 0.49 6.41 0.37 6.59e-10 Atrioventricular conduction; CESC cis rs2342371 0.509 rs9683218 chr3:196211033 C/T cg15048948 chr3:196158458 UBXN7 -0.39 -5.49 -0.32 9.43e-8 Fat distribution (HIV); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17404403 chr4:110737017 GAR1 0.45 6.13 0.35 3.25e-9 Gut microbiota (bacterial taxa); CESC cis rs6582630 0.598 rs12823134 chr12:38514347 T/A cg26384229 chr12:38710491 ALG10B -0.41 -5.41 -0.32 1.38e-7 Drug-induced liver injury (flucloxacillin); CESC trans rs9325144 0.600 rs11183505 chr12:38759110 G/T cg23762105 chr12:34175262 ALG10 0.48 6.23 0.36 1.84e-9 Morning vs. evening chronotype; CESC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7927771 0.542 rs3886262 chr11:47817010 T/G cg18512352 chr11:47633146 NA 0.35 5.33 0.31 2.05e-7 Subjective well-being; CESC cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 0.624 rs2239826 chr6:167504880 T/C cg07741184 chr6:167504864 NA 0.4 6.82 0.39 6.22e-11 Crohn's disease; CESC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg02038168 chr22:39784481 NA -0.62 -7.62 -0.42 4.63e-13 Intelligence (multi-trait analysis); CESC cis rs9394438 0.593 rs10947679 chr6:37543524 C/G cg00985040 chr6:37553208 NA 0.39 6.81 0.39 6.68e-11 IgG glycosylation; CESC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs11577318 0.812 rs3795683 chr1:26632831 C/A cg00852783 chr1:26633632 UBXN11 0.51 7.11 0.4 1.1e-11 Granulocyte percentage of myeloid white cells; CESC cis rs7914558 0.966 rs10786725 chr10:104682357 T/C cg15744005 chr10:104629667 AS3MT -0.35 -5.49 -0.32 9.56e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13745513 chr9:131018379 GOLGA2 -0.57 -6.8 -0.39 6.77e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13973472 chr14:55032305 NA 0.53 6.09 0.35 4.02e-9 Gut microbiome composition (summer); CESC cis rs5753618 0.504 rs9609297 chr22:31893731 G/T cg02404636 chr22:31891804 SFI1 0.39 5.16 0.3 4.9e-7 Colorectal cancer; CESC cis rs708547 0.647 rs6843644 chr4:57891239 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -5.46 -0.32 1.1e-7 Response to bleomycin (chromatid breaks); CESC cis rs7666738 0.753 rs1527520 chr4:98929164 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4144743 1.000 rs72823474 chr17:45321776 G/C cg18085866 chr17:45331354 ITGB3 -0.64 -7.03 -0.4 1.78e-11 Body mass index; CESC cis rs4889855 0.530 rs8072592 chr17:78615361 A/C cg16591659 chr17:78472290 NA 0.33 5.46 0.32 1.09e-7 Fractional excretion of uric acid; CESC cis rs9549367 0.577 rs3024713 chr13:113813321 G/A cg18105134 chr13:113819100 PROZ -0.75 -8.59 -0.47 7.53e-16 Platelet distribution width; CESC cis rs854765 0.551 rs8070748 chr17:17859421 A/G cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC cis rs2455799 0.573 rs2654648 chr3:15775425 T/C cg16303742 chr3:15540471 COLQ -0.4 -6.18 -0.35 2.4e-9 Mean platelet volume; CESC cis rs6062302 0.548 rs4809310 chr20:62228745 G/A cg06363034 chr20:62225388 GMEB2 -0.52 -6.68 -0.38 1.42e-10 Glioblastoma; CESC cis rs6500395 1.000 rs9933314 chr16:48676608 T/C cg04672837 chr16:48644449 N4BP1 0.51 6.31 0.36 1.16e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2204008 0.744 rs12099650 chr12:38317140 C/G cg13010199 chr12:38710504 ALG10B 0.42 5.3 0.31 2.42e-7 Bladder cancer; CESC cis rs2070488 0.804 rs13092473 chr3:38458958 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.81 12.98 0.62 3.7e-30 Electrocardiographic conduction measures; CESC cis rs4466137 0.868 rs1975801 chr5:83022127 A/G cg16102102 chr5:83017553 HAPLN1 -0.51 -7.22 -0.41 5.5e-12 Prostate cancer; CESC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg05368731 chr17:41323189 NBR1 0.78 10.8 0.55 8.75e-23 Menopause (age at onset); CESC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg23758822 chr17:41437982 NA 1.03 14.56 0.67 1.1e-35 Menopause (age at onset); CESC cis rs71403859 0.730 rs17355804 chr16:71717214 A/G cg08717414 chr16:71523259 ZNF19 -0.69 -5.98 -0.34 7.38e-9 Post bronchodilator FEV1; CESC cis rs3806843 1.000 rs7732179 chr5:140199039 G/A cg26395211 chr5:140044315 WDR55 -0.42 -5.32 -0.31 2.19e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7998202 0.667 rs282576 chr13:113358864 A/G cg02820901 chr13:113351484 ATP11A 0.65 5.67 0.33 3.68e-8 Glycated hemoglobin levels; CESC cis rs7127900 0.614 rs72853920 chr11:2206429 T/C cg25635251 chr11:2234043 NA -0.52 -5.81 -0.34 1.8e-8 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15331837 chr8:142232772 SLC45A4 -0.78 -9.31 -0.5 5.19e-18 Gut microbiome composition (summer); CESC cis rs2228479 0.717 rs17233678 chr16:89809962 T/C cg00800038 chr16:89945340 TCF25 -0.88 -7.36 -0.41 2.3e-12 Skin colour saturation; CESC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg21724239 chr8:58056113 NA -0.58 -5.52 -0.32 8.09e-8 Developmental language disorder (linguistic errors); CESC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg03351412 chr1:154909251 PMVK 0.66 8.89 0.48 9.97e-17 Prostate cancer; CESC cis rs2276314 0.857 rs9304155 chr18:33585710 A/C cg19628046 chr18:33552617 C18orf21 0.53 5.98 0.34 7.14e-9 Endometriosis;Drug-induced torsades de pointes; CESC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg06028808 chr11:68637592 NA 0.45 5.21 0.3 3.83e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg21770322 chr7:97807741 LMTK2 0.56 8.61 0.47 6.55e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.87 0.48 1.08e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs12477438 0.765 rs6542846 chr2:99563654 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -8.92 -0.48 7.83e-17 Chronic sinus infection; CESC cis rs6728642 0.908 rs6576996 chr2:97623312 T/C cg26665480 chr2:98280029 ACTR1B -0.72 -7.82 -0.43 1.23e-13 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.18 -0.3 4.45e-7 Gut microbiome composition (summer); CESC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg06634786 chr22:41940651 POLR3H 0.69 6.84 0.39 5.39e-11 Vitiligo; CESC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg09877947 chr5:131593287 PDLIM4 0.48 6.31 0.36 1.16e-9 Acylcarnitine levels; CESC cis rs1552244 0.554 rs2272120 chr3:10046703 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 7.99 0.44 4.24e-14 Alzheimer's disease; CESC cis rs881375 0.678 rs10118357 chr9:123680068 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 6.2 0.36 2.14e-9 Rheumatoid arthritis; CESC cis rs6940638 0.688 rs9379960 chr6:27121325 A/C cg12292205 chr6:26970375 C6orf41 -0.4 -5.46 -0.32 1.1e-7 Intelligence (multi-trait analysis); CESC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg24531977 chr5:56204891 C5orf35 -0.87 -11.03 -0.56 1.58e-23 Initial pursuit acceleration; CESC cis rs524281 0.861 rs12049852 chr11:65884702 T/C cg14036092 chr11:66035641 RAB1B -0.49 -5.39 -0.31 1.53e-7 Electroencephalogram traits; CESC cis rs7617480 0.648 rs14018 chr3:48784270 G/A cg07636037 chr3:49044803 WDR6 0.79 10.66 0.55 2.61e-22 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs3749237 0.595 rs10865955 chr3:49499829 G/A cg07636037 chr3:49044803 WDR6 0.6 8.78 0.47 2e-16 Resting heart rate; CESC cis rs9916302 0.653 rs11657058 chr17:37699378 T/G cg07936489 chr17:37558343 FBXL20 -0.98 -11.47 -0.58 5.54e-25 Glomerular filtration rate (creatinine); CESC cis rs6575793 0.553 rs12436130 chr14:101031036 C/T cg18516195 chr14:101012996 BEGAIN 0.42 5.07 0.3 7.6e-7 Menarche (age at onset); CESC cis rs1008375 1.000 rs1008374 chr4:17683219 G/A cg02297831 chr4:17616191 MED28 0.44 5.64 0.33 4.46e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9811920 0.609 rs2452320 chr3:99645216 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg03467027 chr4:99064603 C4orf37 0.47 5.99 0.35 6.71e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6815814 0.950 rs5743556 chr4:38806851 A/G cg02016764 chr4:38805732 TLR1 -0.63 -7.2 -0.4 6.39e-12 Breast cancer; CESC cis rs4481887 0.927 rs11204631 chr1:248479530 A/G cg00666640 chr1:248458726 OR2T12 0.34 5.32 0.31 2.18e-7 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10633491 chr19:4066815 ZBTB7A -0.64 -7.44 -0.42 1.37e-12 Gut microbiome composition (summer); CESC cis rs17067123 0.614 rs6857116 chr4:180062542 G/A cg26610307 chr4:180072759 NA -0.49 -5.04 -0.3 8.45e-7 Response to hepatitis C treatment; CESC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg05872129 chr22:39784769 NA -0.81 -10.75 -0.55 1.29e-22 Intelligence (multi-trait analysis); CESC cis rs7208859 0.673 rs73263981 chr17:28920502 A/G cg04154034 chr17:28927549 LRRC37B2 0.66 5.85 0.34 1.42e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs782590 0.967 rs11125581 chr2:55796527 C/G cg18811423 chr2:55921094 PNPT1 0.8 12.91 0.62 6.74e-30 Metabolic syndrome; CESC cis rs2235544 0.542 rs11206272 chr1:54470035 G/C cg25741118 chr1:54482237 LDLRAD1 0.24 5.76 0.33 2.29e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs7927771 0.698 rs34467936 chr11:47915299 A/G cg18512352 chr11:47633146 NA -0.61 -9.47 -0.5 1.61e-18 Subjective well-being; CESC trans rs4942242 0.640 rs17460861 chr13:44230078 C/G cg19169023 chr15:41853346 TYRO3 0.63 8.21 0.45 9.59e-15 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10828910 chr2:63850056 LOC388955 -0.69 -8.07 -0.44 2.41e-14 Gut microbiome composition (summer); CESC cis rs7188697 0.922 rs1981961 chr16:58597291 A/T cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg23172400 chr8:95962367 TP53INP1 0.35 6.44 0.37 5.69e-10 Type 2 diabetes; CESC cis rs3026101 0.624 rs1806255 chr17:5314263 G/C cg24500398 chr17:5266808 RABEP1 -0.41 -5.7 -0.33 3.23e-8 Body mass index; CESC cis rs13191362 1.000 rs35424047 chr6:163029715 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.81 8.44 0.46 2.13e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6594713 0.717 rs9326891 chr5:112873928 C/T cg12552261 chr5:112820674 MCC 0.61 5.61 0.33 5.12e-8 Brain cytoarchitecture; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14584092 chr19:2116709 AP3D1 -0.53 -6.46 -0.37 4.97e-10 Gut microbiome composition (summer); CESC cis rs1580019 0.510 rs4723162 chr7:32543804 C/A cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.8 0.76 1.12e-50 Cognitive ability; CESC cis rs6456156 0.565 rs12529238 chr6:167465576 G/A cg07741184 chr6:167504864 NA 0.35 6.08 0.35 4.1e-9 Primary biliary cholangitis; CESC cis rs2073499 1.000 rs6776145 chr3:50316119 C/T cg05260129 chr3:50388622 TUSC4;CYB561D2 -0.75 -7.93 -0.44 6.08e-14 Schizophrenia; CESC trans rs10411161 0.721 rs10401778 chr19:52384315 C/T cg22319618 chr22:45562946 NUP50 -0.71 -7.04 -0.4 1.66e-11 Breast cancer; CESC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg05368731 chr17:41323189 NBR1 0.8 11.19 0.57 4.64e-24 Menopause (age at onset); CESC cis rs72781680 1.000 rs72781631 chr2:24195064 G/A cg20701182 chr2:24300061 SF3B14 0.6 5.45 0.32 1.15e-7 Lymphocyte counts; CESC cis rs7937682 0.883 rs11213941 chr11:111434094 T/C cg09085632 chr11:111637200 PPP2R1B 0.97 13.15 0.63 9.55e-31 Primary sclerosing cholangitis; CESC cis rs4144743 0.759 rs16941731 chr17:45317022 C/T cg18085866 chr17:45331354 ITGB3 0.56 5.17 0.3 4.56e-7 Body mass index; CESC cis rs30380 1.000 rs26510 chr5:96125910 C/T cg16492584 chr5:96139282 ERAP1 -0.34 -5.03 -0.3 9e-7 Cerebrospinal fluid biomarker levels; CESC cis rs34172651 0.617 rs9922436 chr16:24704490 C/G cg00339695 chr16:24857497 SLC5A11 0.43 5.7 0.33 3.18e-8 Intelligence (multi-trait analysis); CESC cis rs4975709 0.838 rs4975752 chr5:1880588 A/C cg12288994 chr5:1860383 NA 0.37 5.91 0.34 1.07e-8 Cardiovascular disease risk factors; CESC cis rs5753618 0.583 rs9606843 chr22:31853371 A/C cg02404636 chr22:31891804 SFI1 0.39 5.3 0.31 2.42e-7 Colorectal cancer; CESC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg20887711 chr4:1340912 KIAA1530 -0.68 -8.88 -0.48 1e-16 Longevity; CESC cis rs11677416 1.000 rs2856841 chr2:113537339 A/G cg27083787 chr2:113543245 IL1A 0.62 7.54 0.42 7.51e-13 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg03433033 chr1:76189801 ACADM 0.68 8.14 0.45 1.54e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1707322 1.000 rs7531911 chr1:46330423 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.52 0.32 8.1e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7923609 1.000 rs4310508 chr10:65138573 A/G cg01631684 chr10:65280961 REEP3 -0.42 -5.18 -0.3 4.48e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs5756813 0.661 rs5995500 chr22:38204640 A/G cg19894588 chr14:64061835 NA -0.68 -8.45 -0.46 1.98e-15 Optic cup area;Vertical cup-disc ratio; CESC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg07701084 chr6:150067640 NUP43 0.48 6.74 0.38 1.01e-10 Lung cancer; CESC cis rs7909074 1.000 rs7909074 chr10:45395839 G/A cg05187965 chr10:45406764 TMEM72 -0.36 -5.48 -0.32 9.69e-8 Mean corpuscular volume; CESC cis rs62064224 0.765 rs62065463 chr17:30732405 G/T cg18200150 chr17:30822561 MYO1D 0.68 10.6 0.55 4.19e-22 Schizophrenia; CESC trans rs61931739 0.500 rs7311284 chr12:34478477 C/G cg26384229 chr12:38710491 ALG10B 0.7 10.6 0.55 3.94e-22 Morning vs. evening chronotype; CESC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg02187348 chr16:89574699 SPG7 0.65 9.11 0.49 2.08e-17 Multiple myeloma (IgH translocation); CESC cis rs12479064 0.724 rs6748200 chr2:100080895 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -7.34 -0.41 2.65e-12 Chronic sinus infection; CESC trans rs1493916 1.000 rs4393645 chr18:31394407 C/T cg27147174 chr7:100797783 AP1S1 -0.52 -7.03 -0.4 1.76e-11 Life satisfaction; CESC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.42 5.33 0.31 2.07e-7 Tonsillectomy; CESC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg23758822 chr17:41437982 NA 1.01 17.05 0.72 1.68e-44 Menopause (age at onset); CESC cis rs72781680 0.898 rs12614616 chr2:23996501 T/G cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs2070488 1.000 rs2070488 chr3:38442490 A/G cg24069376 chr3:38537580 EXOG -0.46 -8.47 -0.46 1.75e-15 Electrocardiographic conduction measures; CESC cis rs10129255 0.500 rs2105991 chr14:107138039 C/G cg07958169 chr14:107095056 NA -0.52 -8.32 -0.45 4.79e-15 Kawasaki disease; CESC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg13880726 chr7:1868755 MAD1L1 0.48 6.37 0.36 8.33e-10 Bipolar disorder and schizophrenia; CESC cis rs79839061 0.518 rs3755961 chr4:895059 A/G cg07828340 chr4:882639 GAK 1.07 8.25 0.45 7.63e-15 Intelligence (multi-trait analysis); CESC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg17971929 chr21:40555470 PSMG1 -0.87 -12.67 -0.61 4.59e-29 Cognitive function; CESC cis rs1348850 0.914 rs3813259 chr2:178257214 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.89 12.87 0.62 9.15e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11098499 1.000 rs6837898 chr4:120179154 C/T cg24375607 chr4:120327624 NA 0.43 5.23 0.31 3.41e-7 Corneal astigmatism; CESC cis rs6547741 0.967 rs4665996 chr2:27814343 T/C cg27432699 chr2:27873401 GPN1 0.49 6.85 0.39 5.03e-11 Oral cavity cancer; CESC cis rs75804782 0.522 rs11889150 chr2:239324542 A/G cg18131467 chr2:239335373 ASB1 -0.6 -7.33 -0.41 2.71e-12 Morning vs. evening chronotype;Chronotype; CESC trans rs1945213 0.694 rs7106894 chr11:55877315 T/C cg15704280 chr7:45808275 SEPT13 0.69 6.67 0.38 1.51e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg24549020 chr5:56110836 MAP3K1 0.65 7.45 0.42 1.3e-12 Initial pursuit acceleration; CESC cis rs6460942 0.659 rs13247370 chr7:12514632 T/C cg02935154 chr7:12443704 VWDE -0.49 -5.15 -0.3 5.05e-7 Coronary artery disease; CESC trans rs1814175 0.645 rs847632 chr11:49926097 C/T cg15704280 chr7:45808275 SEPT13 -0.98 -18.48 -0.75 1.48e-49 Height; CESC cis rs9399135 0.816 rs4134030 chr6:135354094 G/T cg22676075 chr6:135203613 NA 0.5 7.13 0.4 9.64e-12 Red blood cell count; CESC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg05564831 chr3:52568323 NT5DC2 0.45 6.76 0.38 8.65e-11 Bipolar disorder; CESC cis rs7586673 0.578 rs6723841 chr2:161879616 G/T cg22496339 chr2:162101262 NA 0.47 6.01 0.35 6.14e-9 Intelligence (multi-trait analysis); CESC cis rs1348850 0.634 rs2293471 chr2:178487729 T/G cg23306229 chr2:178417860 TTC30B 0.56 6.14 0.35 3.05e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg27165867 chr14:105738592 BRF1 -0.57 -6.17 -0.35 2.52e-9 Mean platelet volume;Platelet distribution width; CESC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg17077180 chr1:38461687 NA 0.47 7.27 0.41 4.04e-12 Coronary artery disease; CESC trans rs8073060 0.533 rs178736 chr17:33928158 G/T cg19694781 chr19:47549865 TMEM160 -0.73 -7.01 -0.4 1.96e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg26732615 chr19:19648335 CILP2;YJEFN3 -0.49 -6.33 -0.36 1.07e-9 Tonsillectomy; CESC cis rs72901758 0.662 rs56326958 chr17:76250439 C/G cg23302638 chr17:76210176 BIRC5 0.48 5.22 0.31 3.6e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs909674 0.775 rs4821896 chr22:39833437 T/C cg01416388 chr22:39784598 NA -0.58 -7.27 -0.41 4.08e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs2952156 0.920 rs8078228 chr17:37834998 C/T cg20243544 chr17:37824526 PNMT 0.63 8.38 0.46 3.08e-15 Asthma; CESC cis rs787274 0.619 rs1475293 chr9:115619587 C/T cg13803584 chr9:115635662 SNX30 0.53 5.17 0.3 4.6e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg26119090 chr2:26468346 HADHA;HADHB 0.97 10.77 0.55 1.12e-22 Gut microbiome composition (summer); CESC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg06634786 chr22:41940651 POLR3H 0.68 6.78 0.38 7.6e-11 Vitiligo; CESC cis rs13242816 1.000 rs12706090 chr7:116104045 A/G cg04696780 chr7:116139425 CAV2 0.6 5.71 0.33 3.04e-8 P wave duration; CESC cis rs10870270 1.000 rs4880246 chr10:133764064 C/T cg26149184 chr10:133730230 NA 0.38 5.13 0.3 5.68e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs9640161 0.750 rs4395803 chr7:150025367 A/C cg17279839 chr7:150038598 RARRES2 0.41 5.04 0.3 8.44e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg22105103 chr4:187893119 NA 0.47 6.95 0.39 2.75e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg06808227 chr14:105710500 BRF1 -0.61 -7.31 -0.41 3.21e-12 Mean platelet volume;Platelet distribution width; CESC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg21724239 chr8:58056113 NA 0.58 5.97 0.34 7.54e-9 Developmental language disorder (linguistic errors); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13338022 chr15:43029438 CDAN1 -0.47 -6.79 -0.38 7.4e-11 Gambling; CESC cis rs910316 1.000 rs7303 chr14:75520065 T/C cg11812906 chr14:75593930 NEK9 0.89 14.86 0.67 9.77e-37 Height; CESC cis rs12701220 0.503 rs12702047 chr7:1132720 G/A cg02733842 chr7:1102375 C7orf50 -0.4 -5.08 -0.3 7.05e-7 Bronchopulmonary dysplasia; CESC cis rs2933343 0.621 rs789241 chr3:128585752 G/A cg24203234 chr3:128598194 ACAD9 0.41 5.69 0.33 3.33e-8 IgG glycosylation; CESC trans rs61931739 0.500 rs11053274 chr12:34547605 G/A cg13010199 chr12:38710504 ALG10B 0.49 6.24 0.36 1.71e-9 Morning vs. evening chronotype; CESC cis rs7737355 0.738 rs3776001 chr5:130957992 T/A cg06307176 chr5:131281290 NA 0.38 5.04 0.3 8.68e-7 Life satisfaction; CESC cis rs4727027 0.901 rs1534197 chr7:148771970 T/C cg23583168 chr7:148888333 NA -0.78 -11.74 -0.59 6.48e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4906332 1.000 rs55731474 chr14:103878481 G/A cg09975044 chr14:104007538 NA 0.46 6.4 0.37 7.09e-10 Coronary artery disease; CESC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg16049864 chr8:95962084 TP53INP1 0.63 9.82 0.52 1.33e-19 Type 2 diabetes; CESC cis rs6800768 0.633 rs62255804 chr3:24149034 G/A cg10674438 chr3:24145617 LOC152024 -0.47 -6.46 -0.37 5.08e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg00310523 chr12:86230176 RASSF9 0.32 5.15 0.3 5.03e-7 Major depressive disorder; CESC cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg12365402 chr11:9010492 NRIP3 -0.37 -5.76 -0.33 2.28e-8 Hemoglobin concentration; CESC cis rs61996546 0.622 rs11637029 chr15:26836107 T/A cg15066197 chr15:26874202 GABRB3 -0.35 -5.07 -0.3 7.55e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs9894429 0.789 rs7502346 chr17:79603741 T/C cg13777783 chr17:79615861 NA -0.33 -5.24 -0.31 3.24e-7 Eye color traits; CESC cis rs6502050 0.805 rs4789740 chr17:80119202 T/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.44 -0.32 1.2e-7 Life satisfaction; CESC cis rs2425143 1.000 rs11696947 chr20:34312658 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -7.58 -0.42 5.86e-13 Blood protein levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22515636 chr2:109150313 NA -0.52 -7.56 -0.42 6.71e-13 Gambling; CESC cis rs611744 0.647 rs9969614 chr8:109260581 A/G cg21045802 chr8:109455806 TTC35 0.45 5.65 0.33 4.03e-8 Dupuytren's disease; CESC cis rs9911578 0.967 rs686425 chr17:56776730 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.44 0.69 8.18e-39 Intelligence (multi-trait analysis); CESC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg24399712 chr22:39784796 NA -0.83 -11.67 -0.58 1.15e-25 Intelligence (multi-trait analysis); CESC cis rs7044106 0.762 rs1547267 chr9:123408736 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 8.63 0.47 5.83e-16 Hip circumference adjusted for BMI; CESC cis rs3813567 0.759 rs12594550 chr15:78959037 C/G cg05914723 chr15:78953907 NA -0.47 -6.18 -0.35 2.45e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC trans rs9951602 0.512 rs1599633 chr18:76643526 T/C cg02800362 chr5:177631904 HNRNPAB 0.62 8.1 0.45 1.96e-14 Obesity-related traits; CESC cis rs4132509 0.696 rs10927062 chr1:243889364 A/G cg21452805 chr1:244014465 NA 0.45 5.54 0.32 7.12e-8 RR interval (heart rate); CESC cis rs4728302 0.869 rs7792492 chr7:133595316 C/T cg10665199 chr7:133106180 EXOC4 0.39 5.37 0.31 1.71e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs34779708 0.931 rs34087268 chr10:35346724 T/G cg04310649 chr10:35416472 CREM -0.51 -6.0 -0.35 6.31e-9 Inflammatory bowel disease;Crohn's disease; CESC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg01341218 chr17:43662625 NA -0.85 -10.21 -0.53 7.25e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2066819 1.000 rs116535779 chr12:56739261 A/G cg26714650 chr12:56694279 CS -1.22 -14.6 -0.67 8.06e-36 Psoriasis vulgaris; CESC cis rs12410462 0.681 rs113316536 chr1:227547033 T/G cg10327440 chr1:227177885 CDC42BPA -0.67 -5.69 -0.33 3.43e-8 Major depressive disorder; CESC cis rs703842 0.616 rs4760332 chr12:58222672 A/C cg02175503 chr12:58329896 NA -0.47 -5.79 -0.33 2.01e-8 Multiple sclerosis; CESC cis rs6967414 0.786 rs9639026 chr7:6746736 A/G cg09896999 chr7:6746977 ZNF12 -0.55 -6.95 -0.39 2.79e-11 Hematocrit;Hemoglobin concentration; CESC cis rs7264396 0.563 rs2425111 chr20:34319765 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.88 0.39 4.29e-11 Total cholesterol levels; CESC cis rs9300255 0.596 rs11057207 chr12:123730891 T/G cg05973401 chr12:123451056 ABCB9 0.45 5.45 0.32 1.13e-7 Neutrophil percentage of white cells; CESC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg22143856 chr6:28129313 ZNF389 0.42 5.26 0.31 2.91e-7 Parkinson's disease; CESC cis rs10392 0.543 rs6028200 chr20:37540615 C/T cg27552599 chr20:37590471 DHX35 0.39 5.62 0.33 4.87e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -7.49 -0.42 1.05e-12 Developmental language disorder (linguistic errors); CESC cis rs36096196 0.891 rs12081179 chr1:2251119 A/G cg00093522 chr1:2252019 NA 0.44 6.15 0.35 2.86e-9 Coronary artery disease; CESC cis rs7100689 0.784 rs4934083 chr10:82116501 G/C cg09936400 chr10:82049201 MAT1A 0.36 5.07 0.3 7.61e-7 Post bronchodilator FEV1; CESC cis rs7666738 0.830 rs11947578 chr4:98930462 T/G cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7000551 0.689 rs2449339 chr8:22387981 G/A cg12081754 chr8:22256438 SLC39A14 0.39 5.29 0.31 2.52e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg17178900 chr1:205818956 PM20D1 0.49 7.2 0.4 6.27e-12 Menarche (age at onset); CESC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg05863683 chr7:1912471 MAD1L1 0.45 6.87 0.39 4.55e-11 Bipolar disorder and schizophrenia; CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.44 6.81 0.39 6.41e-11 Bipolar disorder; CESC trans rs78472555 0.633 rs2570930 chr15:100214935 C/T cg17514665 chr17:1657533 SERPINF2 0.45 6.09 0.35 3.88e-9 Post bronchodilator FEV1/FVC ratio in COPD; CESC cis rs7927771 0.839 rs59360790 chr11:47669175 T/C cg20307385 chr11:47447363 PSMC3 -0.4 -5.09 -0.3 6.73e-7 Subjective well-being; CESC trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.39 -0.46 2.92e-15 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09547170 chr10:105726688 SLK -0.61 -6.91 -0.39 3.59e-11 Gut microbiome composition (summer); CESC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg24503407 chr1:205819492 PM20D1 0.45 6.27 0.36 1.46e-9 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs17539620 0.519 rs871071 chr6:154837667 T/C cg20019720 chr6:154832845 CNKSR3 0.43 6.31 0.36 1.18e-9 Lipoprotein (a) levels; CESC cis rs42648 0.935 rs42664 chr7:89984409 A/G cg23697855 chr7:89950296 NA 0.27 5.12 0.3 5.74e-7 Homocysteine levels; CESC cis rs4803468 0.967 rs2304243 chr19:41942708 C/G cg09537434 chr19:41945824 ATP5SL 1.06 19.76 0.77 5e-54 Height; CESC cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg00033643 chr7:134001901 SLC35B4 0.43 5.61 0.33 5.1e-8 Mean platelet volume; CESC cis rs2289328 0.823 rs35565646 chr15:40660515 G/A cg13931752 chr15:40660718 DISP2 0.47 5.81 0.34 1.81e-8 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); CESC cis rs7605827 0.930 rs10164574 chr2:15677258 G/A cg19274914 chr2:15703543 NA 0.36 6.4 0.37 6.95e-10 Educational attainment (years of education); CESC cis rs9911578 0.757 rs8081906 chr17:56631907 A/T cg05425664 chr17:57184151 TRIM37 0.43 5.43 0.32 1.26e-7 Intelligence (multi-trait analysis); CESC cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg23248424 chr5:179741104 GFPT2 -0.56 -7.71 -0.43 2.57e-13 Height; CESC cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg23711669 chr6:146136114 FBXO30 0.94 12.46 0.61 2.26e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.954 rs9998585 chr4:120396802 T/A cg09307838 chr4:120376055 NA 0.92 13.12 0.63 1.21e-30 Corneal astigmatism; CESC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg14983838 chr19:29218262 NA 0.38 5.2 0.3 3.94e-7 Methadone dose in opioid dependence; CESC cis rs9487023 1 rs9487023 chr6:109590004 A/G cg01475377 chr6:109611718 NA -0.43 -6.7 -0.38 1.26e-10 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; CESC cis rs4595586 0.545 rs4142846 chr12:39395140 C/T cg26384229 chr12:38710491 ALG10B 0.43 6.14 0.35 2.95e-9 Morning vs. evening chronotype; CESC cis rs6570726 0.935 rs442254 chr6:145849118 T/C cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 2e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs10463316 0.862 rs1983171 chr5:150778691 A/G cg03212797 chr5:150827313 SLC36A1 -0.54 -7.15 -0.4 8.64e-12 Metabolite levels (Pyroglutamine); CESC cis rs2274273 0.870 rs3825616 chr14:55853288 G/C cg04306507 chr14:55594613 LGALS3 0.3 5.91 0.34 1.07e-8 Protein biomarker; CESC cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs11944107 chr4:98931638 G/C cg03467027 chr4:99064603 C4orf37 0.46 5.6 0.33 5.39e-8 Colonoscopy-negative controls vs population controls; CESC trans rs10448044 1.000 rs10448044 chr8:80103432 T/C cg08211306 chr6:46097784 ENPP4 0.42 6.08 0.35 4.2e-9 Suicide in bipolar disorder; CESC cis rs9902453 0.967 rs55744550 chr17:28475729 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 8.02 0.44 3.43e-14 Coffee consumption (cups per day); CESC cis rs950776 0.518 rs12916483 chr15:78832397 G/A cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.06e-7 Sudden cardiac arrest; CESC cis rs367615 0.661 rs9326773 chr5:108833523 C/T cg17395555 chr5:108820864 NA 0.63 11.25 0.57 2.95e-24 Colorectal cancer (SNP x SNP interaction); CESC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.29 0.57 2.21e-24 Alzheimer's disease; CESC cis rs1728785 1.000 rs1728789 chr16:68595776 C/T cg02972257 chr16:68554789 NA -0.59 -6.7 -0.38 1.23e-10 Ulcerative colitis; CESC cis rs1580019 0.587 rs6951955 chr7:32548761 A/T cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.8 0.76 1.12e-50 Cognitive ability; CESC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.03 -0.3 9.22e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12898849 chr1:178511736 C1orf220 0.6 6.54 0.37 3.07e-10 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg17372223 chr3:52568218 NT5DC2 0.42 6.47 0.37 4.6e-10 Bipolar disorder; CESC cis rs7949030 0.504 rs2516633 chr11:62371773 A/C cg23462726 chr11:62437636 C11orf83;C11orf48 0.45 5.97 0.34 7.59e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9486719 1.000 rs12210146 chr6:96903962 A/G cg18709589 chr6:96969512 KIAA0776 0.57 6.2 0.36 2.18e-9 Migraine;Coronary artery disease; CESC cis rs3768617 0.510 rs2333620 chr1:183100555 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs11648796 0.757 rs66649828 chr16:766078 A/G cg00802000 chr16:706648 WDR90 -0.39 -5.16 -0.3 4.74e-7 Height; CESC cis rs644148 0.785 rs117048220 chr19:44965555 G/A cg15540054 chr19:45004280 ZNF180 0.66 7.89 0.44 7.86e-14 Personality dimensions; CESC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg10691866 chr7:65817282 TPST1 0.32 5.18 0.3 4.37e-7 Aortic root size; CESC cis rs3096299 0.967 rs7205785 chr16:89458984 A/G cg08392591 chr16:89556376 ANKRD11 0.43 5.45 0.32 1.13e-7 Multiple myeloma (IgH translocation); CESC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs9611519 0.894 rs8136923 chr22:41470522 G/A cg03806693 chr22:41940476 POLR3H -0.57 -5.94 -0.34 8.97e-9 Neuroticism; CESC cis rs8067354 0.957 rs9896742 chr17:57826530 T/G cg02344993 chr17:57696989 CLTC 0.49 6.31 0.36 1.14e-9 Hemoglobin concentration; CESC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg16325326 chr1:53192061 ZYG11B 0.53 7.5 0.42 9.67e-13 Monocyte count; CESC trans rs10435719 0.744 rs11250175 chr8:11792758 G/T cg15556689 chr8:8085844 FLJ10661 0.54 6.58 0.37 2.47e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs1707322 1.000 rs6687301 chr1:46382852 T/C cg05343316 chr1:45956843 TESK2 0.44 5.41 0.32 1.39e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.6 0.64 2.58e-32 Prudent dietary pattern; CESC cis rs11997175 0.575 rs56942690 chr8:33820308 G/A ch.8.33884649F chr8:33765107 NA 0.59 7.35 0.41 2.41e-12 Body mass index; CESC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg19468946 chr17:37922297 IKZF3 0.39 5.04 0.3 8.72e-7 Glomerular filtration rate (creatinine); CESC cis rs2479106 0.591 rs4836935 chr9:126345893 T/G cg16191174 chr9:126692580 DENND1A 0.37 5.04 0.3 8.66e-7 Polycystic ovary syndrome; CESC cis rs193541 0.632 rs30063 chr5:122295693 G/A cg19412675 chr5:122181750 SNX24 0.46 5.42 0.32 1.37e-7 Glucose homeostasis traits; CESC cis rs959260 1.000 rs4789188 chr17:73397871 A/C cg20590849 chr17:73267439 MIF4GD -0.52 -5.95 -0.34 8.46e-9 Systemic lupus erythematosus; CESC cis rs9858213 1 rs9858213 chr3:49731861 G/T cg03060546 chr3:49711283 APEH -0.57 -6.8 -0.39 7.07e-11 Educational attainment; CESC cis rs7474896 0.609 rs1830612 chr10:37999883 A/G cg25427524 chr10:38739819 LOC399744 -0.45 -5.26 -0.31 3.04e-7 Obesity (extreme); CESC trans rs7726839 0.540 rs72703087 chr5:598029 C/T cg25482853 chr8:67687455 SGK3 1.04 10.14 0.53 1.27e-20 Obesity-related traits; CESC cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.77 -12.47 -0.61 2.14e-28 Personality dimensions; CESC trans rs16917919 0.632 rs35712032 chr10:19106327 G/A cg13853761 chr11:64863232 C11orf2 -0.48 -6.02 -0.35 5.87e-9 Brain structure (hippocampal volume); CESC cis rs6502050 0.697 rs8078634 chr17:80126208 C/T cg11859384 chr17:80120422 CCDC57 -0.41 -5.71 -0.33 3.03e-8 Life satisfaction; CESC cis rs10896135 0.526 rs624561 chr11:66414915 C/T cg24851651 chr11:66362959 CCS -0.55 -7.33 -0.41 2.75e-12 Bipolar disorder; CESC cis rs854765 0.583 rs11869536 chr17:17826528 T/A cg04398451 chr17:18023971 MYO15A -0.67 -9.6 -0.51 6.42e-19 Total body bone mineral density; CESC cis rs2354432 0.607 rs3766524 chr1:146729093 A/G cg25205988 chr1:146714368 CHD1L -1.01 -8.37 -0.46 3.47e-15 Mitochondrial DNA levels; CESC cis rs1400745 0.718 rs799681 chr14:35350579 A/G cg16230307 chr14:35515116 FAM177A1 0.44 5.24 0.31 3.23e-7 Monocyte count; CESC cis rs2997447 0.655 rs1317709 chr1:26384690 A/C cg19633962 chr1:26362018 EXTL1 -0.48 -5.24 -0.31 3.26e-7 QRS complex (12-leadsum); CESC cis rs992157 0.731 rs1399132 chr2:219159770 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.7 9.53 0.51 1.06e-18 Colorectal cancer; CESC cis rs9916302 0.861 rs11078913 chr17:37671714 G/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.81 -0.59 3.91e-26 Glomerular filtration rate (creatinine); CESC trans rs709082 0.680 rs709103 chr3:191471306 T/C cg25305879 chr2:106814630 NA 0.4 6.44 0.37 5.56e-10 Colonoscopy-negative controls vs population controls; CESC cis rs921968 0.643 rs585859 chr2:219383121 C/T cg02176678 chr2:219576539 TTLL4 0.39 6.82 0.39 6.07e-11 Mean corpuscular hemoglobin concentration; CESC cis rs4950322 0.634 rs4950415 chr1:146822702 G/C cg22381352 chr1:146742008 CHD1L -0.48 -5.15 -0.3 5.14e-7 Protein quantitative trait loci; CESC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg01570182 chr17:44337453 NA 0.63 8.65 0.47 5.11e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6545883 0.894 rs7566035 chr2:61520815 C/T cg15711740 chr2:61764176 XPO1 0.4 5.07 0.3 7.35e-7 Tuberculosis; CESC cis rs2479724 0.846 rs2254474 chr6:41843044 T/G cg17623882 chr6:41773611 USP49 -0.41 -5.83 -0.34 1.58e-8 Menarche (age at onset); CESC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.47 6.05 0.35 5.05e-9 Tonsillectomy; CESC cis rs7615952 0.800 rs12489350 chr3:125644116 T/C cg05084668 chr3:125655381 ALG1L -0.5 -6.01 -0.35 6.17e-9 Blood pressure (smoking interaction); CESC cis rs9948 0.655 rs62156232 chr2:97431161 C/A cg01990225 chr2:97406019 LMAN2L -0.98 -7.37 -0.41 2.17e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs1788820 0.917 rs1788825 chr18:21109250 T/C cg14672496 chr18:21087552 C18orf8 0.53 7.11 0.4 1.07e-11 Body mass index; CESC cis rs11098499 0.863 rs11098531 chr4:120465001 G/A cg24375607 chr4:120327624 NA 0.44 5.36 0.31 1.84e-7 Corneal astigmatism; CESC cis rs2730245 0.615 rs2527207 chr7:158743078 A/G cg24397884 chr7:158709396 WDR60 -0.86 -9.18 -0.49 1.24e-17 Height; CESC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg07507251 chr3:52567010 NT5DC2 0.48 8.67 0.47 4.43e-16 Electroencephalogram traits; CESC cis rs7336332 0.517 rs9581842 chr13:27978953 G/C cg01674679 chr13:27998804 GTF3A -0.53 -5.04 -0.3 8.81e-7 Weight; CESC cis rs1395 0.778 rs1978881 chr2:27400850 C/A cg22903471 chr2:27725779 GCKR -0.44 -5.41 -0.32 1.38e-7 Blood metabolite levels; CESC cis rs1008375 1.000 rs28501187 chr4:17643620 G/A cg02297831 chr4:17616191 MED28 0.57 7.34 0.41 2.67e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs644799 0.526 rs506180 chr11:95623109 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.45 5.8 0.34 1.92e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18003189 chr10:30723096 MAP3K8 -0.46 -6.48 -0.37 4.41e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12042107 0.656 rs1342780 chr1:91198676 A/C cg13456504 chr1:91191583 NA 0.35 6.12 0.35 3.27e-9 Educational attainment; CESC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.61 -0.33 5.18e-8 Depression; CESC cis rs6831352 0.918 rs1042364 chr4:100045574 T/C cg12011299 chr4:100065546 ADH4 0.59 6.68 0.38 1.41e-10 Alcohol dependence; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg20432401 chr2:114252811 CBWD2 0.41 6.18 0.35 2.37e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs72945132 0.882 rs67244582 chr11:70122009 G/A cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs12822507 0.868 rs12830917 chr12:12792516 C/A cg09462578 chr12:12878428 APOLD1 -0.45 -5.71 -0.33 3.06e-8 Systemic lupus erythematosus; CESC cis rs1129187 0.837 rs4714634 chr6:42901120 G/A cg05552183 chr6:42928497 GNMT 0.76 11.57 0.58 2.45e-25 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1620921 0.505 rs11756055 chr6:161210622 C/T cg01280913 chr6:161186852 NA -0.38 -5.43 -0.32 1.28e-7 Lipoprotein (a) - cholesterol levels; CESC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg22968622 chr17:43663579 NA -1.22 -16.23 -0.71 1.35e-41 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1707322 0.752 rs28719889 chr1:46202283 C/T cg03146154 chr1:46216737 IPP 0.81 11.41 0.57 8.44e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6690583 0.524 rs12045710 chr1:85451765 T/C cg22153463 chr1:85462885 MCOLN2 0.71 7.13 0.4 9.73e-12 Serum sulfate level; CESC cis rs4835473 1.000 rs4835473 chr4:144903572 A/T cg25736465 chr4:144833511 NA 0.41 6.19 0.36 2.33e-9 Immature fraction of reticulocytes; CESC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.35 -0.31 1.95e-7 Life satisfaction; CESC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg03934478 chr11:495069 RNH1 0.56 5.43 0.32 1.25e-7 Body mass index; CESC trans rs2727020 0.658 rs4980442 chr11:49445016 G/T cg15704280 chr7:45808275 SEPT13 -0.9 -15.56 -0.69 3.08e-39 Coronary artery disease; CESC cis rs2721195 0.614 rs12719778 chr8:145879883 T/C cg15320075 chr8:145703422 NA 0.49 6.5 0.37 3.86e-10 Age at first birth; CESC cis rs10743315 0.557 rs77344887 chr12:19312751 C/T cg02471346 chr12:19282374 PLEKHA5 0.75 5.66 0.33 3.91e-8 Gut microbiota (bacterial taxa); CESC cis rs7134594 0.617 rs9668192 chr12:109860911 T/A cg19025524 chr12:109796872 NA -0.4 -5.68 -0.33 3.62e-8 HDL cholesterol; CESC cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg06627628 chr2:24431161 ITSN2 -0.67 -6.32 -0.36 1.13e-9 Lymphocyte counts; CESC cis rs10504073 0.669 rs341799 chr8:50036574 A/G cg00325661 chr8:49890786 NA 0.51 7.54 0.42 7.35e-13 Blood metabolite ratios; CESC cis rs2933343 0.700 rs6787833 chr3:128656184 A/G cg24203234 chr3:128598194 ACAD9 0.44 6.01 0.35 6e-9 IgG glycosylation; CESC cis rs9905704 0.681 rs2531728 chr17:56539792 T/C cg12560992 chr17:57184187 TRIM37 0.63 5.87 0.34 1.33e-8 Testicular germ cell tumor; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26565884 chr16:89187106 ACSF3 0.45 6.57 0.37 2.59e-10 Fibrinogen levels; CESC cis rs644799 0.931 rs496305 chr11:95567035 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.46 0.37 4.92e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.75 0.33 2.41e-8 Bipolar disorder; CESC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg00750074 chr16:89608354 SPG7 -0.37 -5.23 -0.31 3.37e-7 Multiple myeloma (IgH translocation); CESC cis rs9549367 0.789 rs2316442 chr13:113877487 C/T cg00898013 chr13:113819073 PROZ -0.51 -6.99 -0.39 2.18e-11 Platelet distribution width; CESC cis rs1976403 0.633 rs1697422 chr1:21821897 T/C cg04349561 chr1:21808255 NBPF3 -0.41 -6.01 -0.35 6.27e-9 Liver enzyme levels (alkaline phosphatase); CESC cis rs8072100 0.846 rs7214799 chr17:45702099 C/T cg08085267 chr17:45401833 C17orf57 0.41 5.17 0.3 4.67e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2882667 0.964 rs12055237 chr5:138307306 A/G cg04439458 chr5:138467593 SIL1 -0.37 -5.8 -0.34 1.92e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg18876405 chr7:65276391 NA 0.53 7.32 0.41 3.01e-12 Aortic root size; CESC cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg05347473 chr6:146136440 FBXO30 0.56 6.88 0.39 4.39e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.44 5.42 0.32 1.36e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05147328 chr17:79849438 ANAPC11;THOC4 0.48 6.24 0.36 1.71e-9 Gut microbiota (bacterial taxa); CESC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg23034840 chr1:205782522 SLC41A1 0.68 8.43 0.46 2.21e-15 Menarche (age at onset); CESC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg00339695 chr16:24857497 SLC5A11 0.5 6.57 0.37 2.58e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg17724175 chr1:150552817 MCL1 0.42 6.92 0.39 3.3e-11 Tonsillectomy; CESC cis rs2404618 0.587 rs6994849 chr8:1492839 G/T cg13402656 chr8:1511478 DLGAP2 0.65 9.64 0.51 4.94e-19 Lung cancer; CESC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg06600287 chr1:53387719 ECHDC2 -0.29 -5.1 -0.3 6.48e-7 Monocyte count; CESC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg24060327 chr5:131705240 SLC22A5 -0.64 -7.11 -0.4 1.11e-11 Breast cancer; CESC cis rs7520050 0.966 rs6656992 chr1:46333068 C/G cg03146154 chr1:46216737 IPP -0.48 -6.22 -0.36 1.98e-9 Red blood cell count;Reticulocyte count; CESC trans rs1814175 0.817 rs10769648 chr11:50013992 T/C cg15704280 chr7:45808275 SEPT13 -1.05 -21.18 -0.79 6.15e-59 Height; CESC cis rs1878931 0.507 rs35214904 chr16:3410017 C/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.67 -8.06 -0.44 2.68e-14 Body mass index (adult); CESC cis rs9486715 0.867 rs9373907 chr6:96981189 G/A cg06623918 chr6:96969491 KIAA0776 0.86 12.48 0.61 1.97e-28 Headache; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05028089 chr10:79793366 RPS24 -0.56 -6.34 -0.36 1.01e-9 Gut microbiome composition (summer); CESC cis rs2576037 0.796 rs2571018 chr18:44585344 T/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.34 -5.27 -0.31 2.9e-7 Personality dimensions; CESC cis rs9486719 0.857 rs11759769 chr6:97065212 G/A cg18709589 chr6:96969512 KIAA0776 -0.49 -5.45 -0.32 1.14e-7 Migraine;Coronary artery disease; CESC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.76 8.9 0.48 8.92e-17 Alzheimer's disease; CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg05313393 chr1:249120451 SH3BP5L 0.53 6.0 0.35 6.48e-9 Endometrial cancer; CESC cis rs4523957 0.928 rs12938295 chr17:2160854 A/G cg16513277 chr17:2031491 SMG6 0.6 8.18 0.45 1.22e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs644799 1.000 rs580255 chr11:95577929 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.7 8.76 0.47 2.41e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs5769765 0.862 rs9616385 chr22:50313124 C/T cg09872104 chr7:134855509 C7orf49 -0.55 -6.31 -0.36 1.19e-9 Schizophrenia; CESC cis rs11030122 0.632 rs714380 chr11:4059653 A/T cg18678763 chr11:4115507 RRM1 -0.44 -6.03 -0.35 5.57e-9 Mean platelet volume;Platelet distribution width; CESC cis rs7044106 0.791 rs4836831 chr9:123496570 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.47 0.32 1.03e-7 Hip circumference adjusted for BMI; CESC cis rs12681288 0.550 rs4272405 chr8:959014 C/G cg04851639 chr8:1020857 NA -0.28 -5.59 -0.32 5.55e-8 Schizophrenia; CESC cis rs2404602 0.692 rs3110382 chr15:77148688 G/A cg26408565 chr15:76604113 ETFA 0.37 5.3 0.31 2.49e-7 Blood metabolite levels; CESC cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.13 0.3 5.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9896933 0.832 rs79103992 chr17:80855483 G/A cg20578329 chr17:80767326 TBCD -0.77 -7.82 -0.43 1.24e-13 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg26116260 chr4:7069785 GRPEL1 0.97 14.9 0.68 7.15e-37 Monocyte percentage of white cells; CESC cis rs9660992 0.573 rs12140703 chr1:205182865 G/C cg21643547 chr1:205240462 TMCC2 -0.39 -5.56 -0.32 6.46e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs9549367 0.713 rs9549681 chr13:113829873 T/C cg18105134 chr13:113819100 PROZ -0.69 -8.26 -0.45 6.8e-15 Platelet distribution width; CESC cis rs72781680 0.800 rs72790306 chr2:24111311 T/G cg20701182 chr2:24300061 SF3B14 0.78 6.91 0.39 3.59e-11 Lymphocyte counts; CESC cis rs8060686 0.858 rs2271294 chr16:67902326 A/T cg26727032 chr16:67993705 SLC12A4 -0.65 -9.58 -0.51 7.54e-19 HDL cholesterol;Metabolic syndrome; CESC cis rs2290159 0.800 rs7636754 chr3:12678725 C/G cg23032965 chr3:12705835 RAF1 0.54 5.72 0.33 2.9e-8 Cholesterol, total; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18570646 chr15:37391424 MEIS2 0.37 6.02 0.35 5.71e-9 Gambling; CESC cis rs9527 0.590 rs1046411 chr10:104837816 G/A cg04362960 chr10:104952993 NT5C2 0.43 5.5 0.32 9.06e-8 Arsenic metabolism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23667572 chr19:11170597 SMARCA4 0.45 6.5 0.37 3.9e-10 Fibrinogen levels; CESC cis rs2295359 1.000 rs9729046 chr1:67607082 C/G cg03340356 chr1:67600835 NA 0.32 5.46 0.32 1.11e-7 Psoriasis; CESC cis rs17376456 0.825 rs7715562 chr5:93222034 C/T cg21475434 chr5:93447410 FAM172A -0.74 -6.65 -0.38 1.71e-10 Diabetic retinopathy; CESC cis rs644799 0.542 rs10831417 chr11:95467262 A/G cg25622487 chr11:95524042 FAM76B;CEP57 -0.45 -5.8 -0.34 1.93e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07816229 chr5:154317915 GEMIN5 0.54 6.09 0.35 4.05e-9 Gut microbiome composition (summer); CESC cis rs12995491 0.933 rs34366691 chr2:88537451 G/A cg04511125 chr2:88470314 THNSL2 -0.51 -7.44 -0.42 1.38e-12 Response to metformin (IC50); CESC cis rs10851478 0.872 rs7174135 chr15:49755442 T/A cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.16 0.3 4.79e-7 Oral cavity cancer; CESC cis rs2228479 0.867 rs62052189 chr16:89975555 G/C cg00800038 chr16:89945340 TCF25 -0.75 -7.05 -0.4 1.54e-11 Skin colour saturation; CESC cis rs7927592 0.701 rs12226585 chr11:68257861 A/T cg16797656 chr11:68205561 LRP5 -0.51 -8.05 -0.44 2.82e-14 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04674143 chr19:4831543 TICAM1 0.59 6.84 0.39 5.49e-11 Gut microbiome composition (summer); CESC cis rs412050 0.895 rs2329886 chr22:22298474 G/A cg17089214 chr22:22089827 YPEL1 0.67 6.1 0.35 3.76e-9 Attention deficit hyperactivity disorder; CESC cis rs514406 0.893 rs1242317 chr1:53414766 T/C cg16325326 chr1:53192061 ZYG11B 0.91 14.94 0.68 5.09e-37 Monocyte count; CESC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg24829409 chr8:58192753 C8orf71 -0.65 -7.36 -0.41 2.29e-12 Developmental language disorder (linguistic errors); CESC cis rs8017423 0.935 rs17188598 chr14:90722473 A/T cg14092571 chr14:90743983 NA -0.56 -8.49 -0.46 1.54e-15 Mortality in heart failure; CESC cis rs2832191 0.626 rs2254796 chr21:30341891 A/G cg08807101 chr21:30365312 RNF160 -0.85 -12.5 -0.61 1.72e-28 Dental caries; CESC cis rs6500395 0.775 rs7198145 chr16:48666500 A/C cg04672837 chr16:48644449 N4BP1 0.49 6.43 0.37 5.82e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4253772 0.550 rs6008762 chr22:46736228 T/C cg24881330 chr22:46731750 TRMU 0.9 7.81 0.43 1.33e-13 LDL cholesterol;Cholesterol, total; CESC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.48 5.31 0.31 2.29e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs35110281 0.811 rs2838337 chr21:45072621 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 7.11 0.4 1.05e-11 Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09844983 chr1:28240714 RPA2 -0.45 -6.49 -0.37 4.1e-10 Gambling; CESC cis rs6800768 0.633 rs826371 chr3:24163645 C/G cg10674438 chr3:24145617 LOC152024 -0.46 -6.73 -0.38 1.03e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1538970 0.924 rs1826691 chr1:45881262 A/G cg24296786 chr1:45957014 TESK2 0.44 5.13 0.3 5.65e-7 Platelet count; CESC cis rs4727027 0.866 rs2373438 chr7:148780287 C/A cg23583168 chr7:148888333 NA -0.79 -12.11 -0.6 3.74e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg06808227 chr14:105710500 BRF1 -0.56 -6.38 -0.37 7.71e-10 Mean platelet volume;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16837769 chr7:10979899 NDUFA4 -0.56 -6.48 -0.37 4.55e-10 Gut microbiome composition (summer); CESC cis rs9549367 0.756 rs9603814 chr13:113900782 C/T cg18105134 chr13:113819100 PROZ 0.61 7.87 0.44 9.23e-14 Platelet distribution width; CESC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg24503407 chr1:205819492 PM20D1 0.83 12.71 0.62 3.15e-29 Menarche (age at onset); CESC cis rs9815354 0.516 rs115135603 chr3:42031622 T/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs17376456 0.825 rs17372725 chr5:93135588 C/A cg25358565 chr5:93447407 FAM172A 1.1 10.84 0.55 6.88e-23 Diabetic retinopathy; CESC cis rs8020095 0.571 rs1138802 chr14:67439669 C/A cg19548862 chr14:67692701 FAM71D -0.49 -5.89 -0.34 1.16e-8 Depression (quantitative trait); CESC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.75 0.43 1.94e-13 Prudent dietary pattern; CESC cis rs6668108 1 rs6668108 chr1:165691320 A/G cg24409356 chr1:165738333 TMCO1 0.9 8.2 0.45 1.04e-14 Intraocular pressure; CESC cis rs7605827 0.836 rs4396684 chr2:15634404 C/T cg19274914 chr2:15703543 NA 0.33 5.79 0.33 2.02e-8 Educational attainment (years of education); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18176887 chr7:108210328 THAP5;DNAJB9 -0.48 -6.72 -0.38 1.08e-10 Asthma; CESC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg17372223 chr3:52568218 NT5DC2 -0.43 -6.6 -0.38 2.25e-10 Bipolar disorder; CESC cis rs8044868 0.586 rs2070937 chr16:72089740 A/G cg16558253 chr16:72132732 DHX38 -0.41 -6.49 -0.37 4.12e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs9837602 1.000 rs62285478 chr3:99822135 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 6.83 0.39 5.64e-11 Breast cancer; CESC cis rs10256972 0.527 rs2949170 chr7:1216438 A/G cg07308232 chr7:1071921 C7orf50 -0.44 -5.73 -0.33 2.75e-8 Longevity;Endometriosis; CESC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg04756594 chr16:24857601 SLC5A11 -0.5 -5.81 -0.34 1.82e-8 Intelligence (multi-trait analysis); CESC cis rs926938 0.527 rs360667 chr1:115481451 C/G cg12756093 chr1:115239321 AMPD1 -0.46 -6.4 -0.37 6.82e-10 Autism; CESC cis rs6032067 0.929 rs35869085 chr20:43805134 G/C cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.63e-8 Blood protein levels; CESC cis rs2425143 0.512 rs11699653 chr20:34622916 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -7.28 -0.41 3.86e-12 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02927949 chr13:103426033 C13orf27 -0.48 -6.36 -0.36 8.75e-10 Fibrinogen levels; CESC cis rs7937682 0.737 rs682239 chr11:111425105 A/G cg22437258 chr11:111473054 SIK2 -0.61 -7.74 -0.43 2.13e-13 Primary sclerosing cholangitis; CESC cis rs7635838 0.654 rs347585 chr3:11286220 C/T cg00170343 chr3:11313890 ATG7 0.43 5.3 0.31 2.45e-7 HDL cholesterol; CESC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg24881330 chr22:46731750 TRMU 0.81 7.31 0.41 3.09e-12 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg03433033 chr1:76189801 ACADM 0.69 8.34 0.46 4.12e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs17818399 0.926 rs1824050 chr2:46839477 T/C cg02822958 chr2:46747628 ATP6V1E2 0.47 5.73 0.33 2.73e-8 Height; CESC cis rs2573652 1.000 rs2573651 chr15:100514109 T/G cg09918751 chr15:100517450 ADAMTS17 -0.39 -7.61 -0.42 4.66e-13 Height; CESC cis rs67311347 1.000 rs7628796 chr3:40507332 G/A cg24209194 chr3:40518798 ZNF619 -0.52 -6.85 -0.39 5.1e-11 Renal cell carcinoma; CESC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg15352829 chr14:105391018 PLD4 -0.6 -10.51 -0.54 8.09e-22 Rheumatoid arthritis; CESC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg23534315 chr17:78082725 GAA -0.42 -5.67 -0.33 3.78e-8 Yeast infection; CESC trans rs3780486 0.522 rs1328898 chr9:33163271 A/G cg04842962 chr6:43655489 MRPS18A 0.68 10.35 0.54 2.56e-21 IgG glycosylation; CESC cis rs6570726 0.935 rs451349 chr6:145820894 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs656319 0.625 rs34427895 chr8:9875221 G/C cg15556689 chr8:8085844 FLJ10661 -0.53 -6.36 -0.36 9.01e-10 Myopia (pathological); CESC cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg12826209 chr6:26865740 GUSBL1 0.76 8.73 0.47 2.93e-16 Intelligence (multi-trait analysis); CESC cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg15017067 chr4:17643749 FAM184B 0.37 5.2 0.3 3.95e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4237845 0.537 rs10747787 chr12:58260657 A/G cg00677455 chr12:58241039 CTDSP2 0.75 10.52 0.54 7.33e-22 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16256719 chr1:228613082 HIST3H3 0.52 7.12 0.4 1.02e-11 Fibrinogen levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23946709 chr14:23527317 CDH24 -0.49 -6.5 -0.37 3.87e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg05872129 chr22:39784769 NA -0.85 -12.1 -0.6 3.94e-27 Intelligence (multi-trait analysis); CESC cis rs2439831 0.681 rs28578454 chr15:43603032 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.86 10.79 0.55 9.43e-23 Lung cancer in ever smokers; CESC cis rs709400 0.663 rs11628213 chr14:103952453 A/C cg12935359 chr14:103987150 CKB -0.57 -8.39 -0.46 2.88e-15 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17896229 chr20:5294595 PROKR2 -0.49 -6.32 -0.36 1.13e-9 Gut microbiome composition (summer); CESC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg04414720 chr1:150670196 GOLPH3L 0.55 7.44 0.42 1.37e-12 Melanoma; CESC cis rs332507 0.830 rs3772787 chr3:124395368 G/C cg05980111 chr3:124395277 KALRN 0.38 5.08 0.3 7.19e-7 Plateletcrit; CESC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg18016565 chr1:150552671 MCL1 0.33 5.13 0.3 5.67e-7 Tonsillectomy; CESC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg07395648 chr5:131743802 NA -0.44 -5.72 -0.33 2.95e-8 Breast cancer; CESC cis rs4689388 0.926 rs4343789 chr4:6285228 C/G cg00701064 chr4:6280414 WFS1 0.75 13.49 0.64 6.32e-32 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg20744362 chr22:50050164 C22orf34 0.48 8.37 0.46 3.36e-15 Monocyte count;Monocyte percentage of white cells; CESC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.16 0.4 7.99e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2070488 0.804 rs7646429 chr3:38467713 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 13.14 0.63 1.09e-30 Electrocardiographic conduction measures; CESC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg06494592 chr3:125709126 NA -0.49 -5.2 -0.3 3.92e-7 Blood pressure (smoking interaction); CESC cis rs2599510 0.811 rs2243844 chr2:32775984 G/T cg02381751 chr2:32503542 YIPF4 0.43 5.14 0.3 5.4e-7 Interleukin-18 levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21535199 chr1:152749106 LCE1F -0.53 -8.04 -0.44 3e-14 Gut microbiome composition (summer); CESC cis rs9303401 0.659 rs7210700 chr17:56668186 G/A cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.93 0.62 5.59e-30 Cognitive test performance; CESC cis rs7918232 0.830 rs9833 chr10:27400861 G/A cg14442939 chr10:27389572 ANKRD26 0.68 6.51 0.37 3.77e-10 Breast cancer; CESC cis rs36051895 0.554 rs10975027 chr9:5248827 G/A cg02405213 chr9:5042618 JAK2 -0.55 -6.53 -0.37 3.24e-10 Pediatric autoimmune diseases; CESC cis rs4319547 0.695 rs7969429 chr12:122875606 A/G cg05707623 chr12:122985044 ZCCHC8 -0.54 -6.14 -0.35 3.08e-9 Body mass index; CESC cis rs7605827 0.930 rs11898971 chr2:15613678 C/T cg19274914 chr2:15703543 NA -0.36 -6.45 -0.37 5.14e-10 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02671019 chr1:24829462 RCAN3 0.55 6.17 0.35 2.48e-9 Gut microbiome composition (summer); CESC cis rs6032067 0.929 rs17333381 chr20:43804919 C/T cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.5e-8 Blood protein levels; CESC cis rs870825 0.929 rs72689278 chr4:185593718 C/T cg04058563 chr4:185651563 MLF1IP 0.57 5.29 0.31 2.54e-7 Blood protein levels; CESC cis rs8060686 0.545 rs12444313 chr16:68254404 A/C cg26727032 chr16:67993705 SLC12A4 -0.48 -5.18 -0.3 4.5e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs12824058 0.767 rs4759654 chr12:130815559 A/G cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg08564027 chr20:61660810 NA 0.9 15.37 0.69 1.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs6987853 0.933 rs2974353 chr8:42409165 A/C cg09913449 chr8:42400586 C8orf40 0.4 6.38 0.37 7.72e-10 Mean corpuscular hemoglobin concentration; CESC cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg24308560 chr3:49941425 MST1R 0.64 9.22 0.49 9.57e-18 Intelligence (multi-trait analysis); CESC cis rs72945132 0.769 rs3781644 chr11:70190375 G/A cg00319359 chr11:70116639 PPFIA1 0.72 6.84 0.39 5.42e-11 Coronary artery disease; CESC cis rs941873 0.772 rs7086293 chr10:81103247 T/C cg09469691 chr10:81107165 PPIF 0.55 7.49 0.42 1.04e-12 Height; CESC cis rs1950500 0.585 rs8003339 chr14:24817817 T/C cg16194253 chr14:24768981 DHRS1;C14orf21 0.52 6.56 0.37 2.85e-10 Height; CESC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg05872129 chr22:39784769 NA -0.84 -11.4 -0.57 9.27e-25 Intelligence (multi-trait analysis); CESC cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg09035930 chr12:129282057 SLC15A4 0.67 8.84 0.48 1.4e-16 Systemic lupus erythematosus; CESC cis rs477692 1.000 rs567700 chr10:131423126 C/T cg05714579 chr10:131428358 MGMT 0.48 6.49 0.37 4.29e-10 Response to temozolomide; CESC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg08859206 chr1:53392774 SCP2 -0.55 -7.38 -0.41 2.03e-12 Monocyte count; CESC cis rs6460942 1.000 rs17191008 chr7:12417690 T/G cg17427002 chr7:12443146 VWDE -0.55 -5.24 -0.31 3.26e-7 Coronary artery disease; CESC cis rs2637266 0.783 rs846640 chr10:78524293 T/C cg18941641 chr10:78392320 NA 0.4 7.72 0.43 2.36e-13 Pulmonary function; CESC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg04234412 chr22:24373322 LOC391322 -0.49 -7.12 -0.4 1.02e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23967848 chr2:71556215 NA -0.51 -6.72 -0.38 1.1e-10 Gut microbiome composition (summer); CESC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg02569458 chr12:86230093 RASSF9 0.52 7.75 0.43 1.92e-13 Major depressive disorder; CESC cis rs35110281 0.805 rs162402 chr21:44963418 G/C cg04455712 chr21:45112962 RRP1B 0.37 5.5 0.32 9.14e-8 Mean corpuscular volume; CESC cis rs9911578 1.000 rs9915935 chr17:56843048 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -6.9 -0.39 3.8e-11 Intelligence (multi-trait analysis); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10554839 chr10:27529782 ACBD5 0.48 6.08 0.35 4.08e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg07636037 chr3:49044803 WDR6 0.6 7.17 0.4 7.33e-12 Menarche (age at onset); CESC cis rs7851660 0.874 rs2417576 chr9:100628707 C/T cg13688889 chr9:100608707 NA -0.63 -8.87 -0.48 1.09e-16 Strep throat; CESC cis rs11969893 0.737 rs6930051 chr6:101406108 A/G cg12253828 chr6:101329408 ASCC3 0.86 7.12 0.4 1e-11 Economic and political preferences (immigration/crime); CESC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg04166393 chr7:2884313 GNA12 0.62 7.72 0.43 2.35e-13 Height; CESC cis rs7107174 1.000 rs1893448 chr11:77969180 G/A cg02023728 chr11:77925099 USP35 0.42 6.15 0.35 2.85e-9 Testicular germ cell tumor; CESC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg08736216 chr1:53307985 ZYG11A -0.44 -7.35 -0.41 2.54e-12 Monocyte count; CESC cis rs4969178 0.965 rs938351 chr17:76399404 C/T cg20026190 chr17:76395443 PGS1 0.48 7.6 0.42 5.19e-13 HDL cholesterol levels; CESC cis rs7605827 0.930 rs11694458 chr2:15530469 C/G cg19274914 chr2:15703543 NA 0.37 6.74 0.38 9.98e-11 Educational attainment (years of education); CESC cis rs4746818 1.000 rs4284308 chr10:70884861 C/T cg11621586 chr10:70884670 VPS26A 0.93 12.53 0.61 1.35e-28 Left atrial antero-posterior diameter; CESC trans rs7716219 0.731 rs7704138 chr5:54944262 C/T cg15910928 chr8:17658838 MTUS1 -0.41 -6.32 -0.36 1.12e-9 Height; CESC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg19346786 chr7:2764209 NA -0.5 -7.27 -0.41 4.14e-12 Height; CESC cis rs7551222 0.721 rs4951402 chr1:204539122 C/T cg20240347 chr1:204465584 NA -0.27 -5.52 -0.32 8.01e-8 Schizophrenia; CESC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg27297192 chr10:134578999 INPP5A 0.41 5.47 0.32 1.05e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg07332563 chr6:291687 DUSP22 -0.66 -8.38 -0.46 3.11e-15 Menopause (age at onset); CESC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg00310523 chr12:86230176 RASSF9 0.37 5.43 0.32 1.29e-7 Major depressive disorder; CESC cis rs6681460 0.966 rs10749765 chr1:67150280 C/T cg02459107 chr1:67143332 SGIP1 0.38 5.28 0.31 2.64e-7 Presence of antiphospholipid antibodies; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09273779 chr9:35605990 TESK1 -0.43 -6.27 -0.36 1.49e-9 Gambling; CESC cis rs2070488 0.775 rs6794397 chr3:38559307 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.77 12.43 0.61 2.92e-28 Electrocardiographic conduction measures; CESC cis rs3087591 0.922 rs11867284 chr17:29597464 G/A cg24425628 chr17:29625626 OMG;NF1 0.47 5.92 0.34 1e-8 Hip circumference; CESC cis rs2072732 0.821 rs58265521 chr1:2943398 C/A cg03976712 chr1:2946727 NA 0.34 5.35 0.31 1.9e-7 Plateletcrit; CESC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.72 0.38 1.13e-10 Bipolar disorder; CESC cis rs12472274 0.646 rs35468889 chr2:239090959 G/A cg17459225 chr2:239074497 NA 0.49 5.85 0.34 1.41e-8 Phospholipid levels (plasma); CESC cis rs4566357 0.595 rs2272203 chr2:227914655 C/G cg11843606 chr2:227700838 RHBDD1 -0.46 -6.37 -0.36 8.35e-10 Coronary artery disease; CESC cis rs796364 1.000 rs35220450 chr2:200780737 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.95 -7.49 -0.42 1.06e-12 Schizophrenia; CESC cis rs8111998 0.826 rs7245541 chr19:22768771 C/T cg19914732 chr19:22715077 NA 0.37 5.32 0.31 2.25e-7 Corneal structure; CESC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.32 -5.18 -0.3 4.45e-7 Personality dimensions; CESC cis rs1707322 1.000 rs11211228 chr1:46399840 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs75477785 1.000 rs12064085 chr1:210050077 T/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.79 5.15 0.3 5.08e-7 Cleft lip with or without cleft palate; CESC trans rs3942852 1.000 rs3942852 chr11:48115089 C/T cg15704280 chr7:45808275 SEPT13 -0.57 -6.6 -0.38 2.28e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs7917772 0.582 rs10786684 chr10:104323028 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -5.83 -0.34 1.62e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.51 6.04 0.35 5.07e-9 Breast cancer; CESC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg18135555 chr8:22132992 PIWIL2 0.25 5.34 0.31 2e-7 Hypertriglyceridemia; CESC cis rs12887734 0.524 rs12588797 chr14:104300020 C/T cg08213375 chr14:104286397 PPP1R13B -0.41 -6.95 -0.39 2.88e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs12142240 0.667 rs41293287 chr1:46808852 C/T cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg24324837 chr19:49891574 CCDC155 0.43 5.12 0.3 5.98e-7 Multiple sclerosis; CESC cis rs897984 0.806 rs10782001 chr16:30942625 G/A cg00531865 chr16:30841666 NA 0.51 7.12 0.4 1.01e-11 Dementia with Lewy bodies; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10998122 chr11:64008466 FKBP2 0.54 6.09 0.35 3.99e-9 Gut microbiome composition (summer); CESC cis rs193541 0.632 rs6595413 chr5:122156949 G/A cg19412675 chr5:122181750 SNX24 0.45 5.15 0.3 4.98e-7 Glucose homeostasis traits; CESC trans rs12107539 0.918 rs56087525 chr3:151003677 T/G cg05862518 chr17:40277425 RAB5C -0.47 -6.09 -0.35 4.05e-9 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg18240062 chr17:79603768 NPLOC4 0.54 7.11 0.4 1.06e-11 Eye color traits; CESC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.74 -0.33 2.55e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs10751667 0.643 rs7396951 chr11:927355 G/A cg20946044 chr11:1010712 AP2A2 -0.39 -5.26 -0.31 2.96e-7 Alzheimer's disease (late onset); CESC cis rs2414059 0.548 rs3098177 chr15:50783777 A/G cg05456662 chr15:50716270 USP8 -0.44 -5.91 -0.34 1.04e-8 QT interval; CESC cis rs933688 0.818 rs10052492 chr5:90759930 T/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.82 10.63 0.55 3.14e-22 Smoking behavior; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11523538 chr1:244013970 NA 0.58 6.49 0.37 4.31e-10 Gut microbiome composition (summer); CESC cis rs7631605 0.846 rs68159333 chr3:37259739 G/A cg22985146 chr3:37219077 LRRFIP2 -0.35 -5.44 -0.32 1.18e-7 Cerebrospinal P-tau181p levels; CESC cis rs12893668 0.703 rs7140568 chr14:104041374 C/T cg24130564 chr14:104152367 KLC1 -0.47 -5.73 -0.33 2.71e-8 Reticulocyte count; CESC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.08e-9 Aortic root size; CESC cis rs897080 0.515 rs4953088 chr2:44564518 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.55 -6.47 -0.37 4.82e-10 Height; CESC cis rs939574 1.000 rs45488900 chr2:220116509 G/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 7.48 0.42 1.06e-12 Platelet distribution width; CESC cis rs7089973 0.872 rs35622181 chr10:116631976 C/T cg25233709 chr10:116636983 FAM160B1 0.34 5.03 0.3 9.07e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4523957 0.890 rs6503324 chr17:2100512 C/T cg16513277 chr17:2031491 SMG6 -0.67 -9.25 -0.49 7.75e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.61 7.83 0.43 1.21e-13 Menopause (age at onset); CESC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC trans rs983392 0.679 rs636317 chr11:60019150 C/T cg13921652 chr1:144931966 PDE4DIP 0.47 6.0 0.35 6.41e-9 Alzheimer's disease (late onset); CESC cis rs9457247 1.000 rs413232 chr6:167400972 G/A cg23791538 chr6:167370224 RNASET2 -0.59 -8.32 -0.46 4.54e-15 Crohn's disease; CESC cis rs3845702 0.736 rs72960664 chr2:180832672 C/T cg01881094 chr2:180872142 CWC22 1.05 8.97 0.48 5.61e-17 Schizophrenia; CESC cis rs12220238 1.000 rs7076721 chr10:75996682 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.22 0.36 1.89e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2197308 0.605 rs2387437 chr12:37919367 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.69 0.51 3.43e-19 Morning vs. evening chronotype; CESC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.59 7.85 0.43 1.01e-13 Menopause (age at onset); CESC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1568889 0.838 rs10458896 chr11:28057957 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.5 0.64 5.83e-32 Bipolar disorder; CESC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.21 0.36 2.01e-9 Menopause (age at onset); CESC cis rs6460942 0.915 rs17324858 chr7:12305792 G/T cg06484146 chr7:12443880 VWDE -0.4 -5.72 -0.33 2.91e-8 Coronary artery disease; CESC cis rs6088580 0.624 rs6120645 chr20:33025171 C/T cg06115741 chr20:33292138 TP53INP2 0.48 6.14 0.35 3e-9 Glomerular filtration rate (creatinine); CESC cis rs2439831 1.000 rs2439841 chr15:43734749 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.84 11.94 0.59 1.35e-26 Lung cancer in ever smokers; CESC cis rs2439831 1.000 rs1814538 chr15:43759774 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.87 -10.27 -0.53 4.95e-21 Lung cancer in ever smokers; CESC cis rs826838 0.935 rs11169511 chr12:39175802 T/C cg26384229 chr12:38710491 ALG10B 0.78 13.28 0.63 3.36e-31 Heart rate; CESC cis rs9640161 0.636 rs3735171 chr7:150033882 A/G cg17279839 chr7:150038598 RARRES2 0.45 5.4 0.32 1.45e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs7772486 0.686 rs2072911 chr6:146056801 G/A cg23711669 chr6:146136114 FBXO30 -0.86 -12.56 -0.61 1.04e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7208859 0.623 rs9912440 chr17:29148772 A/G cg19761014 chr17:28927070 LRRC37B2 0.74 6.29 0.36 1.27e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg25767906 chr1:53392781 SCP2 -0.43 -5.42 -0.32 1.37e-7 Monocyte count; CESC cis rs11122272 0.735 rs2749705 chr1:231526696 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.73 -0.43 2.3e-13 Hemoglobin concentration; CESC cis rs1499972 0.618 rs62264771 chr3:117647197 G/T cg07612923 chr3:117604196 NA 0.69 6.15 0.35 2.83e-9 Schizophrenia; CESC cis rs9300255 0.537 rs2695482 chr12:123623174 C/T cg05973401 chr12:123451056 ABCB9 0.52 5.82 0.34 1.74e-8 Neutrophil percentage of white cells; CESC cis rs9815354 0.857 rs73073252 chr3:42016891 C/T cg03022575 chr3:42003672 ULK4 0.62 6.55 0.37 2.97e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.24 0.41 4.72e-12 Tonsillectomy; CESC cis rs7020830 0.931 rs13293916 chr9:37136359 C/G cg14294708 chr9:37120828 ZCCHC7 1.28 25.61 0.84 1.21e-73 Schizophrenia; CESC cis rs10901296 0.591 rs7862241 chr9:133669244 C/T cg11464064 chr9:133710261 ABL1 0.63 5.38 0.31 1.64e-7 Bilirubin levels; CESC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg07677032 chr17:61819896 STRADA 0.49 6.64 0.38 1.75e-10 Prudent dietary pattern; CESC cis rs7301826 0.651 rs4759519 chr12:131289508 G/A cg11011512 chr12:131303247 STX2 0.47 5.82 0.34 1.71e-8 Plasma plasminogen activator levels; CESC trans rs1545843 0.593 rs4573731 chr12:84796746 A/C cg03015433 chr16:56623111 MT3 -0.34 -6.14 -0.35 3.04e-9 Major depressive disorder; CESC cis rs561341 0.824 rs1978115 chr17:30220776 A/C cg19193384 chr17:30244184 NA -0.55 -5.87 -0.34 1.31e-8 Hip circumference adjusted for BMI; CESC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.61 6.25 0.36 1.67e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs79839061 0.520 rs6842808 chr4:906903 C/T cg07828340 chr4:882639 GAK 1.07 7.36 0.41 2.31e-12 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26678852 chr1:68297929 GNG12 0.56 6.12 0.35 3.28e-9 Gut microbiome composition (summer); CESC cis rs727505 1.000 rs17246404 chr7:124462661 C/T cg23710748 chr7:124431027 NA -0.48 -7.61 -0.42 4.76e-13 Lewy body disease; CESC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg26939375 chr7:64535504 NA -0.69 -9.87 -0.52 8.83e-20 Calcium levels; CESC cis rs4654899 0.865 rs72988025 chr1:21351441 A/G cg05370193 chr1:21551575 ECE1 0.41 6.17 0.35 2.48e-9 Superior frontal gyrus grey matter volume; CESC cis rs3820068 0.581 rs6669417 chr1:15922371 G/T cg17385448 chr1:15911702 AGMAT 0.43 7.0 0.4 2.1e-11 Systolic blood pressure; CESC cis rs7772486 0.875 rs2748498 chr6:146319166 C/G cg23711669 chr6:146136114 FBXO30 0.83 11.92 0.59 1.62e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.552 rs11078407 chr17:17841083 T/C cg04398451 chr17:18023971 MYO15A -0.7 -10.49 -0.54 9.32e-22 Total body bone mineral density; CESC cis rs7074356 0.831 rs12764048 chr10:82148963 A/G cg05935833 chr10:81318306 SFTPA2 -0.45 -5.77 -0.33 2.15e-8 Borderline personality disorder; CESC cis rs7224737 1.000 rs7219220 chr17:40294280 T/C cg20291162 chr17:40259547 DHX58 -0.4 -5.43 -0.32 1.26e-7 Fibrinogen levels; CESC cis rs7542091 0.669 rs7540534 chr1:210044824 A/T cg09509183 chr1:209979624 IRF6 0.4 5.78 0.33 2.12e-8 Monobrow; CESC cis rs853679 1.000 rs7740487 chr6:28216486 C/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.74 7.26 0.41 4.42e-12 Depression; CESC cis rs7618501 0.521 rs952594 chr3:49908023 G/A cg24308560 chr3:49941425 MST1R -0.65 -9.29 -0.5 5.71e-18 Intelligence (multi-trait analysis); CESC cis rs34779708 0.931 rs2148482 chr10:35348910 A/G cg03585969 chr10:35415529 CREM 0.78 10.34 0.54 2.94e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs12530845 0.945 rs76298187 chr7:135334534 A/G cg23117316 chr7:135346802 PL-5283 -0.4 -5.15 -0.3 4.98e-7 Red blood cell traits; CESC cis rs7927592 0.763 rs10791982 chr11:68337664 T/G cg16797656 chr11:68205561 LRP5 -0.49 -7.51 -0.42 8.79e-13 Total body bone mineral density; CESC cis rs208520 0.526 rs9294682 chr6:66795159 G/A cg07460842 chr6:66804631 NA -1.09 -25.73 -0.85 5.21e-74 Exhaled nitric oxide output; CESC cis rs748404 0.560 rs529611 chr15:43805988 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.58 7.37 0.41 2.18e-12 Lung cancer; CESC cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -6.78 -0.38 7.63e-11 Hemoglobin concentration; CESC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg11890956 chr21:40555474 PSMG1 -0.93 -14.92 -0.68 6.02e-37 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23697400 chr5:64064613 SDCCAG10;SFRS12IP1 -0.63 -7.33 -0.41 2.85e-12 Gut microbiome composition (summer); CESC cis rs7542091 0.637 rs9429826 chr1:210052146 G/A cg23283495 chr1:209979779 IRF6 0.35 5.65 0.33 4.12e-8 Monobrow; CESC cis rs9911578 0.967 rs57869245 chr17:57106630 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.09 -0.3 6.79e-7 Intelligence (multi-trait analysis); CESC cis rs4900538 0.963 rs8017980 chr14:102961341 C/G cg18135206 chr14:102964638 TECPR2 0.83 11.3 0.57 1.92e-24 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs75804782 0.625 rs1039887 chr2:239434892 A/G cg18131467 chr2:239335373 ASB1 -0.55 -5.73 -0.33 2.77e-8 Morning vs. evening chronotype;Chronotype; CESC trans rs12105421 1.000 rs2310353 chr2:103577432 C/T cg26738437 chr17:34308465 CCL16 0.6 6.03 0.35 5.5e-9 Psychosis (atypical); CESC cis rs7267979 0.706 rs6037069 chr20:25234166 C/T cg08601574 chr20:25228251 PYGB 0.39 5.86 0.34 1.38e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1443512 0.812 rs2044210 chr12:54335533 C/G cg12374095 chr12:54320830 NA -0.43 -6.08 -0.35 4.1e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs6788895 1.000 rs75942495 chr3:150477877 G/A cg09723797 chr3:150481914 SIAH2 0.71 5.19 0.3 4.22e-7 Breast cancer; CESC cis rs4595586 0.545 rs12814188 chr12:39380853 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg12365402 chr11:9010492 NRIP3 -0.39 -6.19 -0.36 2.23e-9 Hemoglobin concentration; CESC cis rs703842 0.963 rs923829 chr12:58174306 T/C cg00599273 chr12:58146742 CDK4 0.33 5.03 0.3 9.14e-7 Multiple sclerosis; CESC cis rs4919694 0.536 rs12414777 chr10:104697781 C/T cg04362960 chr10:104952993 NT5C2 0.56 5.85 0.34 1.46e-8 Arsenic metabolism; CESC cis rs763121 0.925 rs5757165 chr22:38994577 C/T cg06022373 chr22:39101656 GTPBP1 0.89 14.97 0.68 3.9e-37 Menopause (age at onset); CESC cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg17366294 chr4:99064904 C4orf37 0.53 6.7 0.38 1.23e-10 Colonoscopy-negative controls vs population controls; CESC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg12288994 chr5:1860383 NA 0.41 6.7 0.38 1.21e-10 Cardiovascular disease risk factors; CESC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg23982607 chr1:1823379 GNB1 -0.8 -12.99 -0.62 3.33e-30 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02007638 chr19:2785672 THOP1 0.54 6.15 0.35 2.9e-9 Gut microbiome composition (summer); CESC cis rs2797160 1.000 rs1935772 chr6:125994708 T/C cg05901451 chr6:126070800 HEY2 -0.45 -6.52 -0.37 3.47e-10 Endometrial cancer; CESC cis rs711245 0.573 rs11899523 chr2:36800918 T/C cg01206211 chr2:36825736 FEZ2 0.34 5.36 0.31 1.81e-7 Height; CESC cis rs7772486 0.754 rs9386134 chr6:146145508 G/A cg23711669 chr6:146136114 FBXO30 1.01 15.11 0.68 1.28e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10129255 0.957 rs8019272 chr14:107192946 C/A cg23076370 chr14:107095027 NA -0.47 -5.92 -0.34 9.93e-9 Kawasaki disease; CESC cis rs4889855 0.530 rs4303599 chr17:78566700 C/T cg16591659 chr17:78472290 NA 0.35 5.73 0.33 2.77e-8 Fractional excretion of uric acid; CESC trans rs629535 0.735 rs525610 chr8:70074535 A/G cg21567404 chr3:27674614 NA 0.88 10.34 0.54 2.74e-21 Dupuytren's disease; CESC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg04369109 chr6:150039330 LATS1 -0.44 -6.07 -0.35 4.43e-9 Lung cancer; CESC cis rs67311347 1.000 rs962847 chr3:40495156 A/G cg24209194 chr3:40518798 ZNF619 -0.56 -7.47 -0.42 1.16e-12 Renal cell carcinoma; CESC cis rs8060686 0.920 rs58588228 chr16:67802010 C/T cg26727032 chr16:67993705 SLC12A4 -0.57 -6.06 -0.35 4.61e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs9987353 0.519 rs2929465 chr8:9064002 C/G cg06636001 chr8:8085503 FLJ10661 -0.53 -6.66 -0.38 1.6e-10 Recombination measurement; CESC cis rs2070997 0.651 rs34149255 chr9:133669533 T/C cg11464064 chr9:133710261 ABL1 0.57 6.7 0.38 1.24e-10 Response to amphetamines; CESC cis rs2072499 0.900 rs2248080 chr1:156195971 T/A cg24450063 chr1:156163899 SLC25A44 0.94 14.42 0.66 3.37e-35 Testicular germ cell tumor; CESC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg23172400 chr8:95962367 TP53INP1 -0.44 -9.22 -0.49 9.93e-18 Type 2 diabetes; CESC cis rs7089973 0.604 rs7095816 chr10:116585109 T/C cg23260525 chr10:116636907 FAM160B1 0.4 7.55 0.42 6.93e-13 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs6840360 0.642 rs2724577 chr4:152354905 C/G cg14684917 chr11:62380363 EML3;ROM1 -0.5 -6.01 -0.35 6.18e-9 Intelligence (multi-trait analysis); CESC cis rs2249694 0.620 rs9419079 chr10:135326985 G/A cg20169779 chr10:135381914 SYCE1 0.42 5.43 0.32 1.26e-7 Obesity-related traits; CESC trans rs10411161 0.702 rs7250138 chr19:52385232 G/C cg22319618 chr22:45562946 NUP50 -0.68 -6.71 -0.38 1.2e-10 Breast cancer; CESC cis rs76525880 0.619 rs2288277 chr17:46651061 T/C cg06593406 chr17:46696139 NA -0.59 -5.05 -0.3 8.35e-7 Colorectal or endometrial cancer; CESC cis rs1670533 1.000 rs6821725 chr4:1060360 C/G cg04106633 chr4:1044584 NA 0.4 5.19 0.3 4.15e-7 Recombination rate (females); CESC cis rs2404602 0.692 rs35077207 chr15:76935306 A/G cg22467129 chr15:76604101 ETFA -0.36 -5.24 -0.31 3.26e-7 Blood metabolite levels; CESC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg18876405 chr7:65276391 NA -0.53 -6.89 -0.39 3.98e-11 Aortic root size; CESC cis rs2070997 0.607 rs11244146 chr9:133675143 A/G cg11464064 chr9:133710261 ABL1 -0.6 -7.25 -0.41 4.7e-12 Response to amphetamines; CESC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg12412775 chr1:25698385 RHCE 0.28 5.08 0.3 7.05e-7 Erythrocyte sedimentation rate; CESC cis rs1355223 0.934 rs11602669 chr11:34695114 G/A cg11058730 chr11:34937778 PDHX;APIP -0.45 -5.99 -0.35 6.67e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg14500267 chr11:67383377 NA 0.34 5.54 0.32 7.16e-8 Mean corpuscular volume; CESC cis rs6496667 0.533 rs2074583 chr15:91009192 T/C cg10434728 chr15:90938212 IQGAP1 0.31 5.47 0.32 1.05e-7 Rheumatoid arthritis; CESC cis rs9467711 0.606 rs9379851 chr6:26354780 A/C cg14345882 chr6:26364793 BTN3A2 0.59 6.2 0.36 2.17e-9 Autism spectrum disorder or schizophrenia; CESC cis rs76419734 0.510 rs2553463 chr4:106730663 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.66 -6.8 -0.39 6.8e-11 Post bronchodilator FEV1; CESC cis rs1775715 0.677 rs2799034 chr10:32175896 A/G cg18675610 chr10:32216311 ARHGAP12 0.34 5.29 0.31 2.55e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1568889 1.000 rs7949704 chr11:28373543 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.0 0.52 3.42e-20 Bipolar disorder; CESC cis rs11098499 0.738 rs28408407 chr4:120376030 C/G cg24375607 chr4:120327624 NA 0.47 5.86 0.34 1.38e-8 Corneal astigmatism; CESC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg01802117 chr1:53393560 SCP2 -0.4 -5.11 -0.3 6.26e-7 Monocyte count; CESC cis rs6424115 0.767 rs11591202 chr1:24102080 A/C cg15997130 chr1:24165203 NA -0.42 -5.27 -0.31 2.85e-7 Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27396760 chr16:81726253 CMIP -0.55 -6.09 -0.35 3.96e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.13 22.71 0.81 4.12e-64 Prudent dietary pattern; CESC cis rs7714584 1.000 rs1896709 chr5:150245032 A/G cg22134413 chr5:150180641 NA 0.49 5.7 0.33 3.1e-8 Crohn's disease; CESC cis rs1801251 0.896 rs4973561 chr2:233687337 C/G cg25237894 chr2:233734115 C2orf82 -0.35 -6.15 -0.35 2.82e-9 Coronary artery disease; CESC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4654899 0.865 rs72975078 chr1:21476196 A/G cg05370193 chr1:21551575 ECE1 0.45 6.85 0.39 5e-11 Superior frontal gyrus grey matter volume; CESC cis rs8072100 0.967 rs62076549 chr17:45579555 T/G cg08085267 chr17:45401833 C17orf57 0.41 5.35 0.31 1.9e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2011503 0.943 rs8102502 chr19:19652746 T/C cg11584989 chr19:19387371 SF4 0.48 5.87 0.34 1.32e-8 Bipolar disorder; CESC trans rs61931739 0.517 rs10844802 chr12:34231001 C/A cg26384229 chr12:38710491 ALG10B 0.63 9.17 0.49 1.41e-17 Morning vs. evening chronotype; CESC cis rs2425143 0.822 rs6060677 chr20:34499368 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.67 -6.0 -0.35 6.3e-9 Blood protein levels; CESC cis rs8060686 0.641 rs2285910 chr16:68104422 T/C cg26727032 chr16:67993705 SLC12A4 -0.53 -6.04 -0.35 5.09e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs666930 0.967 rs637868 chr1:120257110 A/G cg19096424 chr1:120255104 PHGDH 0.5 6.98 0.39 2.41e-11 Breast cancer; CESC cis rs4566357 0.615 rs10178098 chr2:227914425 C/T cg11843606 chr2:227700838 RHBDD1 -0.46 -6.28 -0.36 1.38e-9 Coronary artery disease; CESC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg00684032 chr4:1343700 KIAA1530 0.39 5.43 0.32 1.27e-7 Obesity-related traits; CESC cis rs62005083 1.000 rs72725940 chr14:74553601 T/C cg05179529 chr14:74551516 LIN52;ALDH6A1 0.7 5.22 0.31 3.68e-7 Mean corpuscular volume; CESC cis rs3806843 1.000 rs4151680 chr5:140186657 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.26 -0.31 2.95e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.39 -0.46 2.99e-15 Intelligence (multi-trait analysis); CESC cis rs4803468 0.967 rs4803462 chr19:41908936 T/A cg09537434 chr19:41945824 ATP5SL -1.06 -19.02 -0.76 1.85e-51 Height; CESC cis rs8062405 0.755 rs56209193 chr16:28585636 C/T cg01378222 chr16:28622494 SULT1A1 0.31 5.22 0.31 3.58e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs11758351 0.660 rs16891446 chr6:26226996 A/C cg01420254 chr6:26195488 NA 0.77 8.49 0.46 1.48e-15 Gout;Renal underexcretion gout; CESC trans rs11098499 0.863 rs3775847 chr4:120447642 A/C cg25214090 chr10:38739885 LOC399744 0.7 9.68 0.51 3.69e-19 Corneal astigmatism; CESC cis rs637571 0.522 rs528736 chr11:65705108 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.7 9.76 0.51 1.97e-19 Eosinophil percentage of white cells; CESC cis rs7586673 0.578 rs6723840 chr2:161879615 G/T cg21518248 chr2:162101506 NA 0.43 5.53 0.32 7.81e-8 Intelligence (multi-trait analysis); CESC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg06481639 chr22:41940642 POLR3H 0.59 6.16 0.35 2.73e-9 Vitiligo; CESC trans rs629535 0.547 rs62513420 chr8:70122597 G/A cg21567404 chr3:27674614 NA -0.84 -9.06 -0.49 2.88e-17 Dupuytren's disease; CESC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs11122272 0.735 rs2739506 chr1:231529183 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs6088580 0.524 rs11167241 chr20:33250835 C/T cg24642439 chr20:33292090 TP53INP2 -0.47 -5.53 -0.32 7.81e-8 Glomerular filtration rate (creatinine); CESC cis rs4478858 0.735 rs4949393 chr1:31851875 G/A cg00250761 chr1:31883323 NA -0.26 -5.04 -0.3 8.54e-7 Alcohol dependence; CESC cis rs9488822 0.636 rs1544155 chr6:116346394 C/A cg18764771 chr6:116381957 FRK 0.23 5.71 0.33 3.07e-8 Cholesterol, total;LDL cholesterol; CESC cis rs68170813 0.559 rs7800443 chr7:106910723 G/A cg02696742 chr7:106810147 HBP1 -0.52 -5.07 -0.3 7.42e-7 Coronary artery disease; CESC cis rs4148883 0.504 rs4147544 chr4:100134514 G/T cg12011299 chr4:100065546 ADH4 -0.5 -6.92 -0.39 3.45e-11 Alcohol dependence; CESC cis rs2404602 0.692 rs12904198 chr15:77146978 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.68 -0.33 3.63e-8 Blood metabolite levels; CESC cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg00080972 chr5:178986291 RUFY1 -0.37 -5.46 -0.32 1.12e-7 Lung cancer; CESC cis rs7809950 0.817 rs3779495 chr7:107250260 G/A cg23024343 chr7:107201750 COG5 0.58 7.59 0.42 5.43e-13 Coronary artery disease; CESC cis rs7727544 0.684 rs274561 chr5:131719228 A/C cg24060327 chr5:131705240 SLC22A5 -0.61 -8.04 -0.44 2.99e-14 Blood metabolite levels; CESC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg25204440 chr1:209979598 IRF6 0.36 5.03 0.3 9.14e-7 Monobrow; CESC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg18252515 chr7:66147081 NA 0.5 6.53 0.37 3.31e-10 Aortic root size; CESC cis rs6582630 0.519 rs10880629 chr12:38533611 T/G cg13010199 chr12:38710504 ALG10B 0.46 5.96 0.34 7.85e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg19592336 chr6:28129416 ZNF389 0.42 6.28 0.36 1.37e-9 Cardiac Troponin-T levels; CESC cis rs12410462 0.901 rs79626242 chr1:227650385 A/G cg04117972 chr1:227635322 NA 0.62 6.0 0.35 6.56e-9 Major depressive disorder; CESC cis rs1559088 0.948 rs12610071 chr19:33582687 A/C cg27124370 chr19:33622961 WDR88 0.47 6.15 0.35 2.91e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg11644478 chr21:40555479 PSMG1 0.92 13.03 0.62 2.56e-30 Cognitive function; CESC cis rs4835473 0.932 rs66474962 chr4:144656298 C/T cg25736465 chr4:144833511 NA -0.32 -5.11 -0.3 6.3e-7 Immature fraction of reticulocytes; CESC cis rs4604732 0.536 rs78019731 chr1:247626430 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.77 0.55 1.12e-22 Height; CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg25934064 chr3:52569026 NT5DC2 0.25 5.26 0.31 3.02e-7 Bipolar disorder; CESC cis rs6032067 0.641 rs34602589 chr20:43768734 T/A cg10761708 chr20:43804764 PI3 0.55 6.12 0.35 3.4e-9 Blood protein levels; CESC cis rs10979 1.000 rs9386037 chr6:143891950 T/C cg25407410 chr6:143891975 LOC285740 -0.62 -9.3 -0.5 5.3e-18 Hypospadias; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07155664 chr5:149829590 RPS14 -0.67 -8.22 -0.45 9e-15 Gut microbiome composition (summer); CESC cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg20503657 chr10:835505 NA 0.7 7.89 0.44 7.91e-14 Eosinophil percentage of granulocytes; CESC cis rs16854884 0.657 rs35796781 chr3:143731662 T/C cg06585982 chr3:143692056 C3orf58 0.49 6.26 0.36 1.51e-9 Economic and political preferences (feminism/equality); CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg03274021 chr8:130952480 FAM49B -0.56 -6.11 -0.35 3.58e-9 Subjective well-being; CESC cis rs6120849 0.754 rs3746436 chr20:33586193 C/T cg24642439 chr20:33292090 TP53INP2 0.66 6.52 0.37 3.59e-10 Protein C levels; CESC cis rs9372253 0.678 rs9372251 chr6:110700656 A/G cg19196401 chr6:110721138 DDO -0.4 -5.67 -0.33 3.67e-8 Platelet distribution width; CESC cis rs7208859 0.623 rs11657391 chr17:29194287 G/A cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg05340658 chr4:99064831 C4orf37 0.61 8.18 0.45 1.18e-14 Colonoscopy-negative controls vs population controls; CESC cis rs425277 1.000 rs262651 chr1:2091397 A/G cg16545954 chr1:2118288 C1orf86 0.33 5.59 0.32 5.57e-8 Height; CESC cis rs6088580 0.608 rs1205342 chr20:32921842 C/T cg06115741 chr20:33292138 TP53INP2 -0.44 -5.65 -0.33 4.13e-8 Glomerular filtration rate (creatinine); CESC cis rs6686643 0.762 rs9333433 chr1:165611455 G/C cg19407955 chr1:165599744 MGST3 -0.54 -5.68 -0.33 3.55e-8 Total ventricular volume; CESC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.09 -0.56 9.87e-24 Glomerular filtration rate (creatinine); CESC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg04369109 chr6:150039330 LATS1 -0.39 -5.48 -0.32 9.78e-8 Lung cancer; CESC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.72 6.41 0.37 6.71e-10 Platelet count; CESC cis rs2228479 1.000 rs12596492 chr16:89957169 T/G cg00800038 chr16:89945340 TCF25 -0.94 -7.87 -0.44 9.24e-14 Skin colour saturation; CESC cis rs7224314 1.000 rs6504503 chr17:65386690 A/T cg01507342 chr17:65387096 PITPNC1 -0.46 -5.65 -0.33 4.05e-8 Diisocyanate-induced asthma; CESC cis rs9788682 0.747 rs2656072 chr15:78744292 A/G cg24631222 chr15:78858424 CHRNA5 -0.61 -7.19 -0.4 6.65e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg13206674 chr6:150067644 NUP43 0.39 5.58 0.32 5.93e-8 Lung cancer; CESC cis rs1577917 0.771 rs2842608 chr6:86295858 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.57 -8.02 -0.44 3.45e-14 Response to antipsychotic treatment; CESC cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg15556689 chr8:8085844 FLJ10661 0.62 7.26 0.41 4.29e-12 Mood instability; CESC cis rs7107174 1.000 rs1385600 chr11:77936166 C/T cg02023728 chr11:77925099 USP35 -0.41 -5.75 -0.33 2.41e-8 Testicular germ cell tumor; CESC cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg20307385 chr11:47447363 PSMC3 -0.58 -7.13 -0.4 9.65e-12 Subjective well-being; CESC cis rs2657888 0.965 rs2657903 chr12:56933722 G/A cg23002907 chr12:56915593 RBMS2 0.39 5.15 0.3 5.11e-7 Adiponectin levels; CESC cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.05 0.35 4.95e-9 Colorectal cancer; CESC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg02038168 chr22:39784481 NA 0.61 7.86 0.43 9.8e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20017464 chr17:30677219 MIR632;ZNF207 -0.52 -6.08 -0.35 4.2e-9 Gut microbiome composition (summer); CESC cis rs1595825 0.891 rs76308665 chr2:198518062 C/T cg10820045 chr2:198174542 NA 0.41 5.21 0.3 3.79e-7 Ulcerative colitis; CESC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.58 -0.37 2.45e-10 Bipolar disorder; CESC cis rs1348850 0.750 rs55792594 chr2:178496468 C/T cg22681709 chr2:178499509 PDE11A -0.43 -6.47 -0.37 4.78e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7659604 0.702 rs61217486 chr4:122693973 T/C cg19748678 chr4:122722346 EXOSC9 0.72 9.35 0.5 3.75e-18 Type 2 diabetes; CESC cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.18 0.3 4.42e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6582630 0.537 rs7310749 chr12:38400472 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.26 0.36 1.57e-9 Drug-induced liver injury (flucloxacillin); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06294803 chr3:184033282 EIF4G1 0.58 6.95 0.39 2.89e-11 Gut microbiome composition (summer); CESC trans rs9325144 0.560 rs6582539 chr12:38630097 C/T cg23762105 chr12:34175262 ALG10 0.47 6.43 0.37 5.85e-10 Morning vs. evening chronotype; CESC cis rs3617 0.572 rs2245538 chr3:52852060 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.72 0.33 2.81e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs911555 0.755 rs7147664 chr14:103963420 G/A cg24130564 chr14:104152367 KLC1 -0.5 -6.55 -0.37 2.94e-10 Intelligence (multi-trait analysis); CESC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg06636001 chr8:8085503 FLJ10661 0.47 6.22 0.36 1.93e-9 Mood instability; CESC cis rs2404618 0.504 rs2906567 chr8:1494118 C/T cg13402656 chr8:1511478 DLGAP2 -0.71 -10.68 -0.55 2.3e-22 Lung cancer; CESC cis rs9322193 0.607 rs9383941 chr6:150233236 A/G cg01145232 chr6:150245071 RAET1G -0.53 -6.89 -0.39 3.94e-11 Lung cancer; CESC cis rs10504229 0.871 rs16921952 chr8:58163317 A/T cg24829409 chr8:58192753 C8orf71 -0.63 -8.82 -0.48 1.55e-16 Developmental language disorder (linguistic errors); CESC cis rs6088580 0.634 rs6087587 chr20:33058628 G/T cg08999081 chr20:33150536 PIGU 0.66 11.57 0.58 2.49e-25 Glomerular filtration rate (creatinine); CESC cis rs60843830 0.964 rs62114538 chr2:256116 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.87 11.8 0.59 4.13e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs765787 0.530 rs4775844 chr15:45542048 T/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs4722166 0.508 rs1474348 chr7:22767908 C/G cg13104385 chr7:22767384 IL6 0.43 5.98 0.34 7.13e-9 Lung cancer; CESC cis rs9611565 0.559 rs5751160 chr22:42175695 A/G cg03806693 chr22:41940476 POLR3H 1.17 13.6 0.64 2.7e-32 Vitiligo; CESC cis rs16854884 0.657 rs1979910 chr3:143710268 A/C cg06585982 chr3:143692056 C3orf58 0.52 6.78 0.38 7.72e-11 Economic and political preferences (feminism/equality); CESC cis rs709400 0.628 rs12889639 chr14:103860206 G/A cg12935359 chr14:103987150 CKB 0.49 7.4 0.41 1.78e-12 Body mass index; CESC cis rs9815354 0.812 rs73071239 chr3:41992610 C/A cg03022575 chr3:42003672 ULK4 0.67 5.88 0.34 1.23e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs8017423 0.935 rs11159959 chr14:90733656 C/T cg14092571 chr14:90743983 NA 0.55 8.22 0.45 9.21e-15 Mortality in heart failure; CESC cis rs9911578 1.000 rs9915935 chr17:56843048 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.34 0.69 1.88e-38 Intelligence (multi-trait analysis); CESC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.18 0.3 4.37e-7 Bipolar disorder; CESC cis rs1506636 1.000 rs689341 chr7:123403974 C/A cg03229431 chr7:123269106 ASB15 0.5 6.73 0.38 1.03e-10 Plateletcrit;Platelet count; CESC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg25427524 chr10:38739819 LOC399744 -0.7 -10.24 -0.53 6.01e-21 Extrinsic epigenetic age acceleration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07728084 chr10:21683123 NA 0.46 6.0 0.35 6.46e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.559 rs7290990 chr22:41964357 C/A cg06634786 chr22:41940651 POLR3H -0.62 -6.83 -0.39 5.85e-11 Vitiligo; CESC cis rs3806843 0.706 rs2563302 chr5:140079051 T/C cg26395211 chr5:140044315 WDR55 0.47 6.05 0.35 5.05e-9 Depressive symptoms (multi-trait analysis); CESC cis rs2732480 0.577 rs2732457 chr12:48758379 A/G cg24011408 chr12:48396354 COL2A1 -0.4 -5.51 -0.32 8.55e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9916302 0.904 rs4795357 chr17:37569551 T/C cg00129232 chr17:37814104 STARD3 -0.53 -6.59 -0.38 2.35e-10 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19575883 chr2:172231724 METTL8 -0.66 -7.74 -0.43 2.07e-13 Gut microbiome composition (summer); CESC cis rs735396 1.000 rs735396 chr12:121438844 T/C cg25281562 chr12:121454272 C12orf43 0.39 5.07 0.3 7.47e-7 N-glycan levels; CESC trans rs208520 0.690 rs851467 chr6:66802721 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.82 -0.62 1.32e-29 Exhaled nitric oxide output; CESC cis rs854765 0.583 rs67253360 chr17:17828973 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.18 0.45 1.22e-14 Total body bone mineral density; CESC cis rs1881797 1.000 rs10925062 chr1:247658978 G/C cg11166453 chr1:247681781 NA 0.47 5.83 0.34 1.63e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg08917208 chr2:24149416 ATAD2B 0.6 5.66 0.33 3.99e-8 Lymphocyte counts; CESC cis rs6693567 0.565 rs3754214 chr1:150478623 T/C cg09579323 chr1:150459698 TARS2 0.45 5.57 0.32 6.2e-8 Migraine; CESC cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg20266910 chr6:26577678 NA -0.33 -5.5 -0.32 8.8e-8 Intelligence (multi-trait analysis); CESC trans rs3749237 0.964 rs62260719 chr3:49852419 G/A cg21659725 chr3:3221576 CRBN 0.55 6.46 0.37 4.99e-10 Resting heart rate; CESC cis rs5743618 0.516 rs10024216 chr4:38764112 C/T cg02016764 chr4:38805732 TLR1 -0.33 -5.05 -0.3 8.26e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs7949030 0.588 rs2428548 chr11:62311462 A/G cg22862634 chr11:62369728 EML3;MTA2 0.49 6.83 0.39 5.97e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1801251 1.000 rs1022330 chr2:233577330 G/A cg08000102 chr2:233561755 GIGYF2 0.66 9.02 0.48 3.87e-17 Coronary artery disease; CESC trans rs4942242 0.663 rs17460812 chr13:44215504 A/G cg19169023 chr15:41853346 TYRO3 -0.54 -6.9 -0.39 3.92e-11 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg25204440 chr1:209979598 IRF6 -0.63 -7.81 -0.43 1.3e-13 Cleft lip with or without cleft palate; CESC cis rs6696846 0.740 rs12125465 chr1:205074854 C/A cg00857998 chr1:205179979 DSTYK 0.55 7.28 0.41 3.77e-12 Red blood cell count; CESC cis rs2011503 1.000 rs75525243 chr19:19638218 G/A cg11584989 chr19:19387371 SF4 0.61 7.03 0.4 1.79e-11 Bipolar disorder; CESC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg03576123 chr11:487126 PTDSS2 -1.13 -11.14 -0.56 6.63e-24 Body mass index; CESC cis rs796364 0.806 rs11688168 chr2:200916004 G/A cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC trans rs9850225 0.719 rs4856616 chr3:80466481 A/C cg01092528 chr4:76861103 NAAA 0.42 6.43 0.37 5.89e-10 Erectile dysfunction in type 1 diabetes; CESC cis rs9649465 0.967 rs7791183 chr7:123343719 A/G cg04330084 chr7:123175371 IQUB -0.38 -5.22 -0.31 3.69e-7 Migraine; CESC cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.5 6.12 0.35 3.28e-9 Tonsillectomy; CESC cis rs7123876 0.587 rs11604034 chr11:72364147 G/C cg03713592 chr11:72463424 ARAP1 0.62 5.03 0.3 8.91e-7 Body mass index; CESC cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg05347473 chr6:146136440 FBXO30 0.53 6.63 0.38 1.88e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg07677296 chr16:1877182 HAGH;FAHD1 -0.54 -5.18 -0.3 4.4e-7 Ankle injury; CESC cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.13e-28 Colonoscopy-negative controls vs population controls; CESC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.38 0.31 1.67e-7 Major depressive disorder; CESC cis rs7208859 0.623 rs59447372 chr17:29057585 C/T cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10791097 0.667 rs4937585 chr11:130741940 A/G cg12179176 chr11:130786555 SNX19 0.65 10.06 0.53 2.23e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg05564831 chr3:52568323 NT5DC2 0.44 6.76 0.38 8.84e-11 Bipolar disorder; CESC cis rs6736093 0.966 rs11687451 chr2:112682561 G/A cg12686935 chr2:112915763 FBLN7 -0.44 -5.72 -0.33 2.86e-8 Coronary artery disease; CESC cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.46 0.32 1.1e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg17376030 chr22:41985996 PMM1 -0.81 -8.44 -0.46 2.09e-15 Vitiligo; CESC cis rs6582630 0.502 rs4379906 chr12:38295673 G/A cg26384229 chr12:38710491 ALG10B 0.63 9.25 0.49 7.58e-18 Drug-induced liver injury (flucloxacillin); CESC cis rs7662987 0.517 rs2851263 chr4:100030354 A/G cg13256891 chr4:100009986 ADH5 0.75 8.02 0.44 3.43e-14 Smoking initiation; CESC cis rs7809950 0.953 rs1468336 chr7:107208250 T/C cg23024343 chr7:107201750 COG5 0.44 5.74 0.33 2.62e-8 Coronary artery disease; CESC cis rs10465746 0.780 rs4907190 chr1:84409168 T/C cg10977910 chr1:84465055 TTLL7 0.52 7.14 0.4 9.05e-12 Obesity-related traits; CESC cis rs8180040 0.726 rs7610636 chr3:47064436 A/C cg27129171 chr3:47204927 SETD2 -0.67 -10.07 -0.53 2.01e-20 Colorectal cancer; CESC cis rs11098499 0.908 rs7696649 chr4:120322177 G/A cg09307838 chr4:120376055 NA 0.91 12.42 0.61 3.24e-28 Corneal astigmatism; CESC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg02353165 chr6:42928485 GNMT -0.84 -13.48 -0.64 6.81e-32 Alzheimer's disease in APOE e4+ carriers; CESC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg02951883 chr7:2050386 MAD1L1 0.49 6.4 0.37 7.12e-10 Bipolar disorder and schizophrenia; CESC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg08736216 chr1:53307985 ZYG11A 0.3 5.09 0.3 6.84e-7 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01353464 chr3:38180116 ACAA1;MYD88 0.6 7.02 0.4 1.83e-11 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg25427524 chr10:38739819 LOC399744 -0.65 -9.48 -0.5 1.51e-18 Extrinsic epigenetic age acceleration; CESC cis rs7917772 0.636 rs2249850 chr10:104512006 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.52 6.05 0.35 4.8e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7267979 1.000 rs11087520 chr20:25436827 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.9 0.7 1.91e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs72781680 0.898 rs72788218 chr2:24090435 C/T cg08917208 chr2:24149416 ATAD2B 0.9 8.41 0.46 2.54e-15 Lymphocyte counts; CESC cis rs11078597 0.731 rs8077638 chr17:1640793 C/T cg18436246 chr17:1640651 WDR81 0.62 7.59 0.42 5.36e-13 Serum albumin level; CESC cis rs2075371 0.527 rs1862046 chr7:134023524 T/C cg20476274 chr7:133979776 SLC35B4 0.55 7.25 0.41 4.54e-12 Mean platelet volume; CESC cis rs78456975 0.941 rs28913033 chr2:1523194 T/C cg01028140 chr2:1542097 TPO -0.6 -5.8 -0.34 1.84e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9512730 0.553 rs9512702 chr13:28033485 A/G cg08193333 chr13:27998609 GTF3A 0.44 5.31 0.31 2.29e-7 Schizophrenia; CESC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg24562669 chr7:97807699 LMTK2 0.5 7.43 0.42 1.47e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg02475777 chr4:1388615 CRIPAK 0.4 5.05 0.3 8.18e-7 Longevity; CESC trans rs1994135 0.608 rs1482994 chr12:33713631 T/C cg26384229 chr12:38710491 ALG10B 0.56 7.75 0.43 1.96e-13 Resting heart rate; CESC trans rs11148252 0.508 rs11148260 chr13:53162643 A/C cg18335740 chr13:41363409 SLC25A15 0.61 8.85 0.48 1.3e-16 Lewy body disease; CESC cis rs79349575 0.783 rs4399576 chr17:47009835 G/A cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs6987853 0.933 rs2974339 chr8:42397529 T/C cg09913449 chr8:42400586 C8orf40 0.39 6.13 0.35 3.15e-9 Mean corpuscular hemoglobin concentration; CESC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs9581857 0.615 rs3759435 chr13:27996813 T/G cg01674679 chr13:27998804 GTF3A -0.65 -6.4 -0.37 7.16e-10 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg02428538 chr16:24856791 SLC5A11 -0.48 -5.04 -0.3 8.68e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs6662572 0.686 rs113117837 chr1:46278158 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.11 0.3 6.26e-7 Blood protein levels; CESC cis rs7091068 0.616 rs7901507 chr10:95505424 C/G cg20715218 chr10:95462985 C10orf4 0.58 5.57 0.32 6.17e-8 Urinary tract infection frequency; CESC cis rs17539620 0.624 rs871069 chr6:154837578 A/C cg17771515 chr6:154831774 CNKSR3 0.59 5.85 0.34 1.43e-8 Lipoprotein (a) levels; CESC cis rs6665290 0.835 rs7549465 chr1:227214399 A/C cg10327440 chr1:227177885 CDC42BPA -1.12 -21.97 -0.8 1.21e-61 Myeloid white cell count; CESC cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg23711669 chr6:146136114 FBXO30 1.02 15.96 0.7 1.2e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs477692 0.870 rs475250 chr10:131412558 C/G cg05714579 chr10:131428358 MGMT 0.54 7.47 0.42 1.16e-12 Response to temozolomide; CESC cis rs9911578 0.935 rs12948039 chr17:57045184 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.38 5.18 0.3 4.36e-7 Intelligence (multi-trait analysis); CESC cis rs4728302 0.838 rs10225605 chr7:133591676 G/A cg10665199 chr7:133106180 EXOC4 0.39 5.39 0.31 1.55e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7429990 0.965 rs4858887 chr3:48092017 G/T cg11946769 chr3:48343235 NME6 -0.5 -5.9 -0.34 1.13e-8 Educational attainment (years of education); CESC cis rs11969893 0.850 rs9404058 chr6:101323078 T/C cg12253828 chr6:101329408 ASCC3 1.11 9.64 0.51 4.95e-19 Economic and political preferences (immigration/crime); CESC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg08392591 chr16:89556376 ANKRD11 0.55 7.48 0.42 1.08e-12 Multiple myeloma (IgH translocation); CESC cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg06212747 chr3:49208901 KLHDC8B 0.68 8.05 0.44 2.84e-14 Menarche (age at onset); CESC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg10295955 chr4:187884368 NA 1.06 21.18 0.79 6.03e-59 Lobe attachment (rater-scored or self-reported); CESC cis rs892961 0.932 rs7222170 chr17:75413096 G/A cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg03684893 chr10:554711 DIP2C -0.35 -5.2 -0.3 4.01e-7 Psychosis in Alzheimer's disease; CESC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg14558262 chr17:40713999 COASY 0.78 12.34 0.6 5.9e-28 Colorectal or endometrial cancer; CESC cis rs7267979 0.668 rs2387977 chr20:25599776 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.65 -10.61 -0.55 3.66e-22 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15883249 chr12:13028664 RPL13AP20 -0.56 -6.19 -0.36 2.24e-9 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11287903 chr10:115613834 DCLRE1A;NHLRC2 0.52 7.0 0.4 2.07e-11 Systemic lupus erythematosus; CESC cis rs7208859 0.673 rs999797 chr17:29159329 G/A cg19761014 chr17:28927070 LRRC37B2 0.69 5.34 0.31 2.02e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs754466 0.606 rs7084705 chr10:79596675 A/G cg17075019 chr10:79541650 NA -0.77 -12.39 -0.61 4.02e-28 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9788682 0.895 rs3813570 chr15:78832832 T/C cg24631222 chr15:78858424 CHRNA5 0.8 10.26 0.53 5.12e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs3540 0.574 rs2601205 chr15:90961813 A/G cg22089800 chr15:90895588 ZNF774 0.6 8.03 0.44 3.28e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs17685 0.753 rs1574107 chr7:75685047 A/C cg19862616 chr7:65841803 NCRNA00174 0.86 12.65 0.61 5.35e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg16680214 chr1:154839983 KCNN3 -0.45 -6.94 -0.39 2.95e-11 Prostate cancer; CESC cis rs1801251 0.778 rs2675967 chr2:233736133 C/G cg08000102 chr2:233561755 GIGYF2 -0.61 -7.38 -0.41 2.03e-12 Coronary artery disease; CESC cis rs4523957 0.820 rs2224770 chr17:2205923 T/C cg16513277 chr17:2031491 SMG6 0.59 7.77 0.43 1.78e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs3806843 0.619 rs2569160 chr5:140028774 T/C cg26395211 chr5:140044315 WDR55 0.53 6.81 0.39 6.52e-11 Depressive symptoms (multi-trait analysis); CESC cis rs9399401 0.667 rs6900233 chr6:142717283 C/G cg03128060 chr6:142623767 GPR126 0.38 6.4 0.37 7.02e-10 Chronic obstructive pulmonary disease; CESC cis rs9300255 0.537 rs2695482 chr12:123623174 C/T cg19016782 chr12:123741754 C12orf65 -0.37 -5.07 -0.3 7.56e-7 Neutrophil percentage of white cells; CESC cis rs6732160 0.691 rs6728147 chr2:73423490 A/G cg01422370 chr2:73384389 NA -0.45 -7.86 -0.43 9.68e-14 Intelligence (multi-trait analysis); CESC cis rs643506 0.874 rs645411 chr11:111694490 T/C cg09085632 chr11:111637200 PPP2R1B 0.42 5.46 0.32 1.09e-7 Breast cancer; CESC cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg18512352 chr11:47633146 NA 0.53 7.96 0.44 5e-14 Subjective well-being; CESC cis rs9303401 0.659 rs66514313 chr17:56714057 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.04 13.0 0.62 3.27e-30 Cognitive test performance; CESC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg14393609 chr7:65229607 NA 0.55 7.55 0.42 6.97e-13 Calcium levels; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg22344139 chr1:44435583 DPH2 0.48 6.25 0.36 1.65e-9 Weight; CESC cis rs854765 0.693 rs8079321 chr17:17760789 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.96 0.48 5.8e-17 Total body bone mineral density; CESC cis rs3008870 0.755 rs2815363 chr1:67497221 A/G cg02640540 chr1:67518911 SLC35D1 -0.45 -5.59 -0.32 5.74e-8 Lymphocyte percentage of white cells; CESC cis rs11122272 0.735 rs2486734 chr1:231531392 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05910615 chr19:36248877 HSPB6;C19orf55 0.62 7.72 0.43 2.42e-13 Gut microbiome composition (summer); CESC cis rs897080 0.515 rs1067336 chr2:44625876 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 6.15 0.35 2.8e-9 Height; CESC cis rs7833986 0.501 rs2953901 chr8:56981824 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 6.89e-13 Height; CESC cis rs12765878 1.000 rs4918068 chr10:105644736 T/G cg11005552 chr10:105648138 OBFC1 0.35 5.1 0.3 6.34e-7 Coronary artery disease; CESC trans rs164368 0.568 rs163944 chr5:160633896 C/T cg08125972 chr19:36705377 ZNF565;ZNF146 -0.57 -6.0 -0.35 6.32e-9 Yu-Zhi constitution type in type 2 diabetes; CESC cis rs17376456 0.569 rs7721668 chr5:93290995 G/A cg25358565 chr5:93447407 FAM172A -0.45 -5.35 -0.31 1.92e-7 Diabetic retinopathy; CESC cis rs11690935 0.959 rs12185567 chr2:172560729 A/C cg13550731 chr2:172543902 DYNC1I2 0.96 14.64 0.67 5.9e-36 Schizophrenia; CESC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg23283495 chr1:209979779 IRF6 -0.38 -5.85 -0.34 1.42e-8 Monobrow; CESC cis rs796364 1.000 rs281762 chr2:200799201 C/G cg23649088 chr2:200775458 C2orf69 0.54 5.33 0.31 2.13e-7 Schizophrenia; CESC cis rs7829975 0.777 rs560544 chr8:8637429 G/A cg17143192 chr8:8559678 CLDN23 -0.44 -5.41 -0.32 1.41e-7 Mood instability; CESC cis rs8064299 0.655 rs2305214 chr17:72768970 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.53 6.99 0.39 2.25e-11 Monocyte count; CESC cis rs9399401 0.677 rs11155241 chr6:142664439 T/A cg03128060 chr6:142623767 GPR126 0.37 6.26 0.36 1.58e-9 Chronic obstructive pulmonary disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12152867 chr6:56708725 DST 0.47 6.14 0.35 2.95e-9 Gut microbiota (bacterial taxa); CESC cis rs6565681 0.760 rs9901680 chr17:78378088 A/G cg15383979 chr17:78362278 RNF213;LOC100294362 -0.79 -8.86 -0.48 1.19e-16 Moyamoya disease; CESC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.12 0.53 1.44e-20 Prudent dietary pattern; CESC cis rs67311347 1.000 rs9874499 chr3:40441908 C/T cg09455208 chr3:40491958 NA 0.5 8.54 0.46 1.03e-15 Renal cell carcinoma; CESC cis rs7586673 0.866 rs7579662 chr2:161915810 G/A cg08807892 chr2:162101083 NA 0.44 5.92 0.34 9.81e-9 Intelligence (multi-trait analysis); CESC cis rs10791323 0.572 rs10894755 chr11:133739685 C/T cg15485101 chr11:133734466 NA -0.35 -5.71 -0.33 3.01e-8 Childhood ear infection; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05800758 chr8:101225800 SPAG1 0.47 6.22 0.36 1.92e-9 Gut microbiota (bacterial taxa); CESC cis rs11676348 0.772 rs7422358 chr2:218952778 C/T cg00012203 chr2:219082015 ARPC2 -0.39 -5.07 -0.3 7.49e-7 Ulcerative colitis; CESC trans rs5756813 0.688 rs12484064 chr22:38126746 C/A cg19894588 chr14:64061835 NA -0.65 -7.41 -0.41 1.7e-12 Optic cup area;Vertical cup-disc ratio; CESC cis rs921968 0.643 rs1055816 chr2:219501328 G/A cg02176678 chr2:219576539 TTLL4 0.4 6.93 0.39 3.18e-11 Mean corpuscular hemoglobin concentration; CESC cis rs10423674 0.526 rs12462498 chr19:18832950 A/G cg14292368 chr19:18793705 CRTC1 0.43 5.61 0.33 5.13e-8 Menarche (age at onset); CESC cis rs2294693 0.947 rs736793 chr6:40997919 A/T cg14769373 chr6:40998127 UNC5CL -0.47 -6.58 -0.37 2.5e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg18180107 chr4:99064573 C4orf37 0.43 5.52 0.32 8.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg02773041 chr1:40204384 PPIE 0.51 7.05 0.4 1.51e-11 Blood protein levels; CESC trans rs6828577 0.819 rs366656 chr4:119634694 T/C cg05098011 chr1:151736092 OAZ3;MRPL9 0.48 6.14 0.35 3.01e-9 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs300703 0.542 rs67993758 chr2:179594 C/T cg21211680 chr2:198530 NA -0.91 -10.75 -0.55 1.31e-22 Blood protein levels; CESC cis rs1008375 0.966 rs6449313 chr4:17588320 A/G cg27347728 chr4:17578864 LAP3 0.45 5.24 0.31 3.21e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12477438 0.798 rs6542849 chr2:99578493 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.51 -0.54 7.92e-22 Chronic sinus infection; CESC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.0 -0.4 2.04e-11 Total body bone mineral density; CESC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg16049864 chr8:95962084 TP53INP1 -0.64 -11.12 -0.56 7.79e-24 Type 2 diabetes; CESC cis rs2637266 0.935 rs2583054 chr10:78401442 A/G cg18941641 chr10:78392320 NA 0.45 8.65 0.47 4.9e-16 Pulmonary function; CESC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg14298792 chr15:30685198 CHRFAM7A -0.48 -5.82 -0.34 1.68e-8 Huntington's disease progression; CESC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg21951975 chr1:209979733 IRF6 0.62 7.66 0.43 3.46e-13 Cleft lip with or without cleft palate; CESC cis rs4268898 0.662 rs9917315 chr2:24431501 C/A cg08917208 chr2:24149416 ATAD2B 0.55 5.27 0.31 2.89e-7 Asthma; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg12792366 chr3:37217087 LRRFIP2 0.45 6.18 0.35 2.43e-9 Positive affect; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02375201 chr1:27114675 PIGV -0.52 -6.18 -0.35 2.43e-9 Ulcerative colitis; CESC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.57 -0.32 6.1e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9948 0.655 rs6576981 chr2:97394406 G/C cg01990225 chr2:97406019 LMAN2L -0.87 -7.29 -0.41 3.59e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs2070677 1.000 rs12263487 chr10:135403585 A/G cg20169779 chr10:135381914 SYCE1 -0.9 -11.19 -0.57 4.67e-24 Gout; CESC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.3 -0.36 1.2e-9 Total body bone mineral density; CESC cis rs36051895 0.695 rs10124627 chr9:5025746 T/G cg02405213 chr9:5042618 JAK2 -0.48 -5.97 -0.34 7.77e-9 Pediatric autoimmune diseases; CESC cis rs28489187 0.706 rs3768227 chr1:85804087 A/G cg16011679 chr1:85725395 C1orf52 0.55 6.37 0.36 8.25e-10 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs6430585 0.583 rs59213715 chr2:136646582 A/C cg07169764 chr2:136633963 MCM6 1.24 18.77 0.76 1.37e-50 Corneal structure; CESC cis rs2011503 1.000 rs2965201 chr19:19478051 C/T cg11584989 chr19:19387371 SF4 -0.63 -7.42 -0.41 1.63e-12 Bipolar disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01304440 chr3:32726769 CNOT10 -0.46 -6.07 -0.35 4.35e-9 Gut microbiota (bacterial taxa); CESC cis rs933688 1.000 rs186717 chr5:90780467 T/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.81 10.14 0.53 1.22e-20 Smoking behavior; CESC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg17143192 chr8:8559678 CLDN23 0.7 8.24 0.45 8.14e-15 Obesity-related traits; CESC cis rs9325144 0.555 rs11183215 chr12:38693127 G/A cg26384229 chr12:38710491 ALG10B -0.6 -8.57 -0.47 8.48e-16 Morning vs. evening chronotype; CESC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg12310025 chr6:25882481 NA 0.37 6.15 0.35 2.92e-9 Blood metabolite levels; CESC cis rs6060717 0.536 rs6060704 chr20:34530270 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.78 -6.98 -0.39 2.32e-11 Hip circumference adjusted for BMI; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11037719 chr6:2999695 NQO2 0.5 6.23 0.36 1.82e-9 Gut microbiota (bacterial taxa); CESC cis rs2412819 0.597 rs78282429 chr15:43922003 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.48 7.25 0.41 4.7e-12 Lung cancer; CESC cis rs76878669 0.561 rs7125752 chr11:66162419 C/T cg18002602 chr11:66138449 SLC29A2 -0.44 -7.15 -0.4 8.56e-12 Educational attainment (years of education); CESC cis rs8060686 0.641 rs113258243 chr16:68086656 C/T cg26727032 chr16:67993705 SLC12A4 -0.55 -6.12 -0.35 3.34e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs8077577 0.895 rs62073607 chr17:18071338 A/G cg16794390 chr17:18148240 FLII 0.37 5.08 0.3 7.01e-7 Obesity-related traits; CESC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg03647317 chr4:187891568 NA 0.38 5.55 0.32 6.94e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs6963495 0.818 rs73190149 chr7:105152793 C/T cg13798780 chr7:105162888 PUS7 0.78 8.0 0.44 4.02e-14 Bipolar disorder (body mass index interaction); CESC cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg24920358 chr1:40204285 PPIE 0.41 6.06 0.35 4.56e-9 Blood protein levels; CESC cis rs909674 0.775 rs8138462 chr22:39839670 G/C cg11247378 chr22:39784982 NA -0.58 -8.57 -0.47 8.52e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs9354308 1.000 rs9354308 chr6:66565353 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.53 6.37 0.36 8.27e-10 Metabolite levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11530914 chr16:67281528 FHOD1;SLC9A5 0.49 6.6 0.38 2.22e-10 Gut microbiota (bacterial taxa); CESC cis rs938554 0.826 rs7376960 chr4:9970570 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -5.19 -0.3 4.28e-7 Blood metabolite levels; CESC cis rs2204008 0.774 rs8189620 chr12:38241621 A/G cg13010199 chr12:38710504 ALG10B 0.51 6.33 0.36 1.04e-9 Bladder cancer; CESC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg01017244 chr2:74357527 NA 0.68 9.95 0.52 5.1e-20 Gestational age at birth (maternal effect); CESC cis rs4969178 0.965 rs4969186 chr17:76398404 C/G cg05887092 chr17:76393375 PGS1 0.61 9.98 0.52 4.19e-20 HDL cholesterol levels; CESC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg26335602 chr6:28129616 ZNF389 0.52 6.84 0.39 5.58e-11 Depression; CESC cis rs782590 0.643 rs13009906 chr2:55739434 A/G cg18811423 chr2:55921094 PNPT1 -0.56 -7.82 -0.43 1.25e-13 Metabolic syndrome; CESC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.68 -8.35 -0.46 3.76e-15 Mean platelet volume; CESC cis rs36051895 0.589 rs16922786 chr9:5200714 A/G cg02405213 chr9:5042618 JAK2 -0.5 -5.87 -0.34 1.31e-8 Pediatric autoimmune diseases; CESC cis rs3749237 0.595 rs11130199 chr3:49538799 T/C cg02487422 chr3:49467188 NICN1 0.59 8.52 0.46 1.2e-15 Resting heart rate; CESC cis rs3093024 0.839 rs968334 chr6:167526096 T/C cg07741184 chr6:167504864 NA -0.36 -6.21 -0.36 2.09e-9 Rheumatoid arthritis; CESC cis rs11792861 0.888 rs57314245 chr9:111813832 G/A cg13535736 chr9:111863775 C9orf5 -0.46 -6.27 -0.36 1.43e-9 Menarche (age at onset); CESC cis rs11098499 0.909 rs11723839 chr4:120299673 G/A cg09307838 chr4:120376055 NA 0.92 12.54 0.61 1.23e-28 Corneal astigmatism; CESC cis rs7044106 1.000 rs7044106 chr9:123494062 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.59 6.66 0.38 1.54e-10 Hip circumference adjusted for BMI; CESC cis rs7216064 0.953 rs1599859 chr17:65837193 C/G cg07042672 chr17:66097459 LOC651250 -0.57 -6.68 -0.38 1.38e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs8044868 0.530 rs8059437 chr16:72116467 A/G cg16558253 chr16:72132732 DHX38 -0.38 -6.08 -0.35 4.22e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs116095464 0.558 rs10055405 chr5:265666 C/T cg20965017 chr5:231967 SDHA -0.47 -5.3 -0.31 2.49e-7 Breast cancer; CESC cis rs3780486 0.846 rs10113903 chr9:33122645 C/G cg13443165 chr9:33130375 B4GALT1 -0.45 -6.57 -0.37 2.63e-10 IgG glycosylation; CESC cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg16386425 chr10:429943 DIP2C -0.56 -7.23 -0.41 5.02e-12 Psychosis in Alzheimer's disease; CESC cis rs36051895 0.623 rs2381215 chr9:5262607 C/T cg02405213 chr9:5042618 JAK2 -0.57 -6.95 -0.39 2.9e-11 Pediatric autoimmune diseases; CESC cis rs3761218 0.668 rs6052079 chr20:3774209 G/T cg25011176 chr20:3776985 CDC25B -0.47 -6.22 -0.36 1.93e-9 Bipolar disorder; CESC cis rs11122272 0.701 rs7414807 chr1:231476874 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.37 0.36 8.49e-10 Hemoglobin concentration; CESC cis rs72781680 0.898 rs2879640 chr2:24043573 T/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs6087990 0.735 rs1040554 chr20:31380073 C/T cg13636640 chr20:31349939 DNMT3B 0.77 12.58 0.61 8.78e-29 Ulcerative colitis; CESC trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg15556689 chr8:8085844 FLJ10661 -0.55 -6.93 -0.39 3.16e-11 Neuroticism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13078969 chr12:1799970 ADIPOR2 -0.46 -6.53 -0.37 3.39e-10 Gut microbiota (bacterial taxa); CESC cis rs7903847 0.642 rs11189192 chr10:99149403 G/A cg20016023 chr10:99160130 RRP12 -0.3 -5.16 -0.3 4.93e-7 Granulocyte percentage of myeloid white cells; CESC trans rs73198271 0.653 rs10087633 chr8:8660444 A/G cg23754772 chr18:12253859 CIDEA -0.33 -6.18 -0.35 2.45e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs798766 1.000 rs798719 chr4:1698183 C/T cg05874882 chr4:1763078 NA -0.53 -7.05 -0.4 1.53e-11 Bladder cancer;Urinary bladder cancer; CESC cis rs6500395 1.000 rs3919552 chr16:48716328 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3540 0.554 rs113942266 chr15:91072990 A/G cg22089800 chr15:90895588 ZNF774 -0.64 -8.89 -0.48 9.92e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs61931739 0.500 rs12809868 chr12:34464905 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.28 0.36 1.39e-9 Morning vs. evening chronotype; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg10074409 chr1:209979377 IRF6 0.43 8.41 0.46 2.49e-15 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.57 7.91 0.44 6.81e-14 Intelligence (multi-trait analysis); CESC cis rs8017423 0.967 rs1005788 chr14:90692747 C/T cg14092571 chr14:90743983 NA -0.57 -8.36 -0.46 3.48e-15 Mortality in heart failure; CESC cis rs524281 0.692 rs10791845 chr11:65834340 C/G cg14036092 chr11:66035641 RAB1B 0.58 6.34 0.36 1e-9 Electroencephalogram traits; CESC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg02038168 chr22:39784481 NA -0.59 -7.49 -0.42 1.03e-12 Intelligence (multi-trait analysis); CESC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg09491104 chr22:46646882 C22orf40 -0.51 -6.01 -0.35 6.03e-9 LDL cholesterol;Cholesterol, total; CESC cis rs7267979 0.528 rs2387976 chr20:25599560 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.7 -11.53 -0.58 3.51e-25 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26622502 chr11:65769931 EIF1AD;BANF1 -0.59 -6.25 -0.36 1.66e-9 Gut microbiome composition (summer); CESC cis rs9911578 1.000 rs6503866 chr17:56619581 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.53 -0.32 7.63e-8 Intelligence (multi-trait analysis); CESC cis rs1707322 0.721 rs28817701 chr1:46186050 C/T cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs754466 0.957 rs61854183 chr10:79698077 T/C cg17075019 chr10:79541650 NA -0.73 -8.93 -0.48 7.24e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22066304 chr19:55691730 SYT5 0.49 6.66 0.38 1.61e-10 Fibrinogen levels; CESC cis rs7818345 0.967 rs35029660 chr8:19308126 T/C cg11303988 chr8:19266685 CSGALNACT1 0.36 6.3 0.36 1.2e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs9513627 0.920 rs7320057 chr13:100155586 G/A cg25919922 chr13:100150906 NA 0.65 5.11 0.3 6.31e-7 Obesity-related traits; CESC cis rs6032067 0.929 rs62205504 chr20:43867894 C/G cg10761708 chr20:43804764 PI3 0.5 6.15 0.35 2.83e-9 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07552157 chr3:142720316 SR140 0.63 7.71 0.43 2.57e-13 Gut microbiome composition (summer); CESC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg11764359 chr7:65958608 NA -0.78 -11.43 -0.57 7.35e-25 Aortic root size; CESC cis rs7927771 0.524 rs10838784 chr11:47882341 G/A cg18512352 chr11:47633146 NA 0.36 5.6 0.33 5.27e-8 Subjective well-being; CESC cis rs116095464 0.558 rs59284383 chr5:284525 C/G cg22857025 chr5:266934 NA -1.29 -18.38 -0.75 3.21e-49 Breast cancer; CESC cis rs2070488 0.804 rs2268755 chr3:38501916 A/G cg24069376 chr3:38537580 EXOG -0.32 -5.58 -0.32 6e-8 Electrocardiographic conduction measures; CESC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg14703610 chr5:56206110 C5orf35 -0.41 -5.19 -0.3 4.17e-7 Initial pursuit acceleration; CESC cis rs6842047 1.000 rs6842047 chr4:187133576 A/C cg02012338 chr4:187126139 CYP4V2 0.62 5.38 0.31 1.61e-7 Blood protein levels; CESC cis rs8044995 0.568 rs55675218 chr16:68323647 G/C cg26727032 chr16:67993705 SLC12A4 -0.54 -5.21 -0.3 3.8e-7 Schizophrenia; CESC cis rs10242455 0.702 rs17161700 chr7:98977067 A/G cg25640893 chr7:99214727 ZNF498 0.91 5.66 0.33 4.01e-8 Blood metabolite levels; CESC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg19592336 chr6:28129416 ZNF389 0.61 8.17 0.45 1.28e-14 Depression; CESC cis rs12995849 0.727 rs10200841 chr2:106456387 C/T cg16077055 chr2:106428750 NCK2 0.39 6.06 0.35 4.62e-9 Addiction; CESC cis rs62064224 0.703 rs62065493 chr17:30822620 C/G cg18200150 chr17:30822561 MYO1D 0.75 12.1 0.6 3.9e-27 Schizophrenia; CESC cis rs2742540 0.503 rs982273 chr11:8906862 T/G cg14711859 chr11:8959438 ASCL3 0.38 5.79 0.34 2e-8 Hematocrit; CESC cis rs7402982 0.934 rs6598539 chr15:99204483 T/C cg03437748 chr15:99193247 IGF1R 0.71 11.03 0.56 1.55e-23 Birth weight; CESC cis rs9858542 0.953 rs35261698 chr3:49537839 C/G cg07274523 chr3:49395745 GPX1 0.66 8.05 0.44 2.82e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs72772090 0.539 rs17481759 chr5:96114695 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.14 -0.3 5.45e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg08704250 chr15:31115839 NA 0.69 9.22 0.49 9.79e-18 Huntington's disease progression; CESC cis rs1448094 0.511 rs17279289 chr12:86162792 T/G cg02569458 chr12:86230093 RASSF9 0.49 7.68 0.43 3.15e-13 Major depressive disorder; CESC cis rs8005677 1.000 rs8014936 chr14:23375145 A/G cg01529538 chr14:23388837 RBM23 0.51 6.99 0.39 2.25e-11 Cognitive ability (multi-trait analysis); CESC cis rs10979 1.000 rs9403505 chr6:143885841 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.21 -0.49 9.97e-18 Hypospadias; CESC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg02034447 chr16:89574710 SPG7 0.5 6.35 0.36 9.31e-10 Multiple myeloma (IgH translocation); CESC cis rs9796 0.866 rs2928148 chr15:41401550 G/A cg18705301 chr15:41695430 NDUFAF1 0.42 6.26 0.36 1.58e-9 Menopause (age at onset); CESC cis rs597583 0.715 rs4938400 chr11:117399604 C/A cg27161313 chr11:117392002 DSCAML1 -0.53 -6.03 -0.35 5.47e-9 Putamen volume; CESC cis rs611744 0.583 rs1448148 chr8:109333074 T/A cg21045802 chr8:109455806 TTC35 0.56 6.85 0.39 5.13e-11 Dupuytren's disease; CESC cis rs35110281 0.666 rs2236665 chr21:45108987 C/A cg01579765 chr21:45077557 HSF2BP -0.52 -8.68 -0.47 4.11e-16 Mean corpuscular volume; CESC cis rs4919694 1.000 rs7099987 chr10:104807926 C/T cg04362960 chr10:104952993 NT5C2 0.79 7.08 0.4 1.27e-11 Arsenic metabolism; CESC cis rs17095355 1.000 rs12570423 chr10:111690942 C/T cg00817464 chr10:111662876 XPNPEP1 -0.45 -5.07 -0.3 7.38e-7 Biliary atresia; CESC cis rs7833986 0.501 rs72653951 chr8:56961837 G/A cg26371346 chr8:56986568 SNORD54;RPS20 0.58 5.3 0.31 2.38e-7 Height; CESC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.32 5.59 0.32 5.74e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs858239 0.600 rs7785842 chr7:23141706 T/A cg23682824 chr7:23144976 KLHL7 0.54 7.7 0.43 2.68e-13 Cerebrospinal fluid biomarker levels; CESC cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg20573242 chr4:122745356 CCNA2 0.52 6.53 0.37 3.42e-10 Type 2 diabetes; CESC cis rs988913 0.723 rs4490666 chr6:55000651 C/T cg03513858 chr6:54763001 FAM83B 0.33 5.05 0.3 8.26e-7 Menarche (age at onset); CESC cis rs6460942 0.597 rs13227809 chr7:12525557 G/A cg02935154 chr7:12443704 VWDE -0.55 -5.53 -0.32 7.71e-8 Coronary artery disease; CESC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg02297831 chr4:17616191 MED28 0.44 5.34 0.31 1.99e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs1728785 0.818 rs1728769 chr16:68564186 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs34779708 0.931 rs2384287 chr10:35340559 A/G cg04310649 chr10:35416472 CREM -0.51 -6.01 -0.35 6.07e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.57 0.32 6.26e-8 Depression; CESC cis rs7917772 0.503 rs11191342 chr10:104344450 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.94e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs7246760 1.000 rs2287839 chr19:9940814 C/G cg02900749 chr2:68251473 NA -0.76 -6.38 -0.36 7.69e-10 Pursuit maintenance gain; CESC cis rs17376456 0.877 rs10062711 chr5:93348659 G/A cg25358565 chr5:93447407 FAM172A 1.1 10.64 0.55 3.12e-22 Diabetic retinopathy; CESC cis rs9487051 0.676 rs6910119 chr6:109599263 A/G cg21918786 chr6:109611834 NA -0.37 -5.5 -0.32 9.15e-8 Reticulocyte fraction of red cells; CESC cis rs6570726 1.000 rs436066 chr6:145847127 C/T cg05347473 chr6:146136440 FBXO30 0.44 5.92 0.34 1.02e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg27170947 chr2:26402098 FAM59B -0.83 -10.42 -0.54 1.51e-21 Gut microbiome composition (summer); CESC cis rs9399135 0.967 rs9389258 chr6:135361140 T/C cg22676075 chr6:135203613 NA 0.51 7.3 0.41 3.45e-12 Red blood cell count; CESC cis rs3820068 0.603 rs932602 chr1:15986087 A/G cg13390004 chr1:15929781 NA 0.34 5.49 0.32 9.33e-8 Systolic blood pressure; CESC trans rs11098499 0.908 rs7696649 chr4:120322177 G/A cg25214090 chr10:38739885 LOC399744 0.71 9.87 0.52 9.3e-20 Corneal astigmatism; CESC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg18301423 chr5:131593218 PDLIM4 0.38 5.24 0.31 3.27e-7 Acylcarnitine levels; CESC cis rs1729951 0.546 rs361246 chr3:136695667 G/A cg03617693 chr3:136751559 NA 0.39 5.4 0.31 1.47e-7 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00369061 chr11:129765581 NFRKB 0.59 6.46 0.37 5.12e-10 Gut microbiome composition (summer); CESC cis rs2130392 0.892 rs11728389 chr4:185622046 C/T cg21366198 chr4:185655624 MLF1IP 0.43 6.08 0.35 4.24e-9 Kawasaki disease; CESC cis rs1904096 0.506 rs17021463 chr4:95224812 T/G cg11021082 chr4:95130006 SMARCAD1 -0.62 -9.82 -0.52 1.3e-19 Type 2 diabetes; CESC cis rs7116495 0.609 rs3750907 chr11:71822560 T/C cg10381502 chr11:71823885 C11orf51 1.16 7.22 0.41 5.55e-12 Severe influenza A (H1N1) infection; CESC cis rs9914988 0.943 rs4794838 chr17:27131095 T/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg20151795 chr6:28129481 ZNF389 0.4 5.09 0.3 6.94e-7 Parkinson's disease; CESC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg03934478 chr11:495069 RNH1 0.54 5.15 0.3 4.97e-7 Body mass index; CESC cis rs6500602 0.727 rs2160567 chr16:4535557 C/T cg08645402 chr16:4508243 NA 0.53 8.53 0.46 1.18e-15 Schizophrenia; CESC cis rs473651 0.904 rs501333 chr2:239336045 G/A cg18131467 chr2:239335373 ASB1 1.03 21.68 0.8 1.23e-60 Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04367680 chr8:74005697 C8orf84 -0.56 -6.67 -0.38 1.5e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23805785 chr1:32671112 IQCC 0.58 6.93 0.39 3.2e-11 Gut microbiome composition (summer); CESC cis rs72945132 0.882 rs66627443 chr11:70199036 C/G cg14191688 chr11:70257035 CTTN 0.41 5.1 0.3 6.49e-7 Coronary artery disease; CESC cis rs11638352 0.661 rs2042738 chr15:44426553 T/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -5.29 -0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs72634258 0.945 rs161800 chr1:8042402 A/T cg00042356 chr1:8021962 PARK7 0.58 6.24 0.36 1.77e-9 Inflammatory bowel disease; CESC trans rs694739 0.726 rs516124 chr11:64128423 G/T cg01888411 chr11:34378293 ABTB2 0.39 6.03 0.35 5.39e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg27572855 chr1:25598939 RHD -0.5 -8.75 -0.47 2.49e-16 Plateletcrit;Mean corpuscular volume; CESC cis rs2933343 0.700 rs789238 chr3:128636715 A/G cg11901034 chr3:128598214 ACAD9 -0.39 -5.69 -0.33 3.28e-8 IgG glycosylation; CESC cis rs72634258 0.945 rs225131 chr1:8095486 T/C cg00042356 chr1:8021962 PARK7 0.53 6.01 0.35 6.21e-9 Inflammatory bowel disease; CESC cis rs2204008 0.666 rs67792345 chr12:38204698 T/C cg13010199 chr12:38710504 ALG10B 0.53 6.43 0.37 5.94e-10 Bladder cancer; CESC trans rs10506458 0.915 rs79133015 chr12:63396838 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.35 -18.82 -0.76 9.08e-51 Hemostatic factors and hematological phenotypes; CESC cis rs7208859 0.673 rs56846352 chr17:29119188 C/T cg04154034 chr17:28927549 LRRC37B2 0.55 5.24 0.31 3.25e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10088262 0.591 rs13270541 chr8:124794849 G/A cg20713898 chr8:124780851 FAM91A1 -0.67 -9.11 -0.49 2.02e-17 Pancreatic cancer; CESC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg19163074 chr7:65112434 INTS4L2 0.41 5.21 0.3 3.76e-7 Aortic root size; CESC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.71e-40 Aortic root size; CESC cis rs870825 0.616 rs28563856 chr4:185635581 G/A cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs7666738 0.546 rs1863602 chr4:98909304 T/C cg17366294 chr4:99064904 C4orf37 0.52 6.58 0.37 2.54e-10 Colonoscopy-negative controls vs population controls; CESC cis rs60871478 1.000 rs9195 chr7:825786 C/T cg27478167 chr7:817139 HEATR2 0.43 5.19 0.3 4.21e-7 Cerebrospinal P-tau181p levels; CESC cis rs2361718 0.500 rs12451697 chr17:78100690 T/A cg27427491 chr17:78079615 GAA -0.39 -5.74 -0.33 2.59e-8 Yeast infection; CESC cis rs3008870 0.816 rs1118392 chr1:67366549 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.7 -9.06 -0.49 2.9e-17 Lymphocyte percentage of white cells; CESC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg24324837 chr19:49891574 CCDC155 0.51 5.99 0.35 6.76e-9 Multiple sclerosis; CESC cis rs1784581 0.802 rs9365355 chr6:162414604 A/G cg17173639 chr6:162384350 PARK2 0.61 9.42 0.5 2.25e-18 Itch intensity from mosquito bite; CESC cis rs921968 0.541 rs3770216 chr2:219443717 A/G cg02176678 chr2:219576539 TTLL4 -0.54 -9.87 -0.52 9.27e-20 Mean corpuscular hemoglobin concentration; CESC cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg22431228 chr1:16359049 CLCNKA -0.47 -7.82 -0.43 1.22e-13 Dilated cardiomyopathy; CESC cis rs425277 0.583 rs3128334 chr1:2038662 G/A cg04315214 chr1:2043799 PRKCZ 0.45 7.32 0.41 2.99e-12 Height; CESC cis rs7078219 0.524 rs6584277 chr10:101278055 A/G cg09788492 chr10:101292477 NKX2-3 0.32 5.98 0.34 7.23e-9 Dental caries; CESC cis rs992157 0.643 rs10191283 chr2:219056755 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.54 0.51 9.55e-19 Colorectal cancer; CESC cis rs6088580 0.634 rs6059896 chr20:33111783 T/C cg24642439 chr20:33292090 TP53INP2 0.5 6.55 0.37 3.05e-10 Glomerular filtration rate (creatinine); CESC cis rs2635047 0.656 rs1355594 chr18:44763994 T/G cg24371990 chr18:44770781 NA 0.41 6.68 0.38 1.4e-10 Educational attainment; CESC cis rs8002861 0.765 rs12868462 chr13:44453480 C/T cg14210620 chr13:44453864 C13orf31;CCDC122 -0.44 -5.57 -0.32 6.27e-8 Leprosy; CESC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg07507251 chr3:52567010 NT5DC2 0.4 7.03 0.4 1.78e-11 Bipolar disorder; CESC cis rs9486719 1.000 rs28623445 chr6:96899116 G/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.21e-15 Migraine;Coronary artery disease; CESC cis rs11792861 0.962 rs11789624 chr9:111796231 T/C cg05043794 chr9:111880884 C9orf5 -0.42 -6.92 -0.39 3.35e-11 Menarche (age at onset); CESC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg18876405 chr7:65276391 NA 0.56 7.45 0.42 1.34e-12 Aortic root size; CESC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs116095464 0.558 rs7708515 chr5:234989 C/G cg22857025 chr5:266934 NA -1.28 -18.64 -0.75 3.96e-50 Breast cancer; CESC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg22029157 chr1:209979665 IRF6 0.76 8.93 0.48 7.36e-17 Cleft lip with or without cleft palate; CESC cis rs7312933 0.703 rs10880268 chr12:42599122 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.4 0.37 6.94e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg17724175 chr1:150552817 MCL1 0.42 6.45 0.37 5.2400000000000005e-10 Melanoma; CESC cis rs1595825 0.838 rs7603283 chr2:198517592 A/G cg10820045 chr2:198174542 NA 0.41 5.21 0.3 3.79e-7 Ulcerative colitis; CESC cis rs735396 0.694 rs2264750 chr12:121450165 C/T cg25281562 chr12:121454272 C12orf43 0.5 6.2 0.36 2.18e-9 N-glycan levels; CESC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg05863683 chr7:1912471 MAD1L1 0.36 5.17 0.3 4.65e-7 Bipolar disorder and schizophrenia; CESC cis rs3820928 0.874 rs55959848 chr2:227805426 C/A cg05526886 chr2:227700861 RHBDD1 -0.39 -5.04 -0.3 8.54e-7 Pulmonary function; CESC cis rs8058578 1.000 rs13338946 chr16:30700858 T/C cg00531865 chr16:30841666 NA -0.42 -5.44 -0.32 1.23e-7 Multiple myeloma; CESC cis rs2235642 0.893 rs2076445 chr16:1592266 A/T cg09080909 chr16:1797204 MAPK8IP3 -0.38 -5.27 -0.31 2.85e-7 Coronary artery disease; CESC cis rs3771570 1.000 rs62193205 chr2:242316512 C/T cg21155796 chr2:242212141 HDLBP 0.6 5.27 0.31 2.89e-7 Prostate cancer; CESC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.4 0.41 1.78e-12 Tonsillectomy; CESC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.69 -7.84 -0.43 1.07e-13 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.61 8.13 0.45 1.66e-14 Menopause (age at onset); CESC cis rs712039 0.652 rs1829453 chr17:35809843 A/G cg16670864 chr17:35848621 DUSP14 0.41 5.13 0.3 5.52e-7 Tuberculosis; CESC cis rs12618769 0.543 rs2278211 chr2:99149946 G/A cg10123293 chr2:99228465 UNC50 0.42 5.43 0.32 1.3e-7 Bipolar disorder; CESC cis rs79057730 0.599 rs112891948 chr7:816059 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.87 7.3 0.41 3.39e-12 Initial pursuit acceleration; CESC cis rs3820068 0.603 rs6429767 chr1:15963334 G/A cg16988262 chr1:15930761 NA 0.34 5.45 0.32 1.16e-7 Systolic blood pressure; CESC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg22862634 chr11:62369728 EML3;MTA2 0.47 6.35 0.36 9.12e-10 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10573403 chr14:36003118 INSM2 0.44 6.14 0.35 2.94e-9 Systemic lupus erythematosus; CESC cis rs7582720 0.945 rs72934601 chr2:204031137 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 6.87 0.39 4.55e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00526316 chr1:151043472 GABPB2 -0.44 -6.12 -0.35 3.3e-9 Height; CESC cis rs7520050 0.966 rs1707335 chr1:46571921 C/T cg03146154 chr1:46216737 IPP -0.43 -5.52 -0.32 8.27e-8 Red blood cell count;Reticulocyte count; CESC cis rs4979906 1.000 rs11002249 chr10:79447228 C/T cg07817648 chr10:79422355 NA -0.49 -5.52 -0.32 8.19e-8 Mortality in heart failure; CESC cis rs5769765 0.646 rs9616205 chr22:50309915 A/T cg02269571 chr22:50332266 NA -0.61 -7.66 -0.43 3.57e-13 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05236972 chr22:46933233 CELSR1 0.57 6.88 0.39 4.34e-11 Gut microbiome composition (summer); CESC cis rs12464559 0.649 rs9288006 chr2:152661831 G/A cg01189475 chr2:152685088 ARL5A 0.65 5.88 0.34 1.26e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg21285383 chr16:89894308 SPIRE2 0.32 5.76 0.33 2.32e-8 Vitiligo; CESC trans rs7047415 1.000 rs7029315 chr9:98544912 A/G cg00788170 chr1:227921688 SNAP47;LOC100130093;JMJD4 -0.45 -6.12 -0.35 3.28e-9 Alzheimer disease and age of onset; CESC cis rs4689388 0.750 rs10001190 chr4:6284633 C/T cg00701064 chr4:6280414 WFS1 -0.66 -10.31 -0.54 3.46e-21 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.61e-7 Life satisfaction; CESC cis rs9300255 0.699 rs11057204 chr12:123725827 T/C cg05973401 chr12:123451056 ABCB9 0.51 5.62 0.33 4.77e-8 Neutrophil percentage of white cells; CESC cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg16339924 chr4:17578868 LAP3 -0.66 -8.07 -0.44 2.54e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg18876405 chr7:65276391 NA 0.5 6.68 0.38 1.43e-10 Aortic root size; CESC cis rs7089973 0.624 rs11196940 chr10:116593791 T/G cg23260525 chr10:116636907 FAM160B1 0.41 7.44 0.42 1.45e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06134974 chr12:51477539 CSRNP2 0.6 6.94 0.39 2.94e-11 Gut microbiome composition (summer); CESC cis rs6163 0.588 rs3818708 chr10:104503584 C/T cg04362960 chr10:104952993 NT5C2 0.41 5.58 0.32 5.9e-8 Waist circumference;Hip circumference; CESC cis rs6963495 0.818 rs6955796 chr7:105170321 T/G cg19920283 chr7:105172520 RINT1 0.69 6.54 0.37 3.15e-10 Bipolar disorder (body mass index interaction); CESC cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.51 0.46 1.33e-15 Colonoscopy-negative controls vs population controls; CESC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg04025307 chr7:1156635 C7orf50 0.44 5.41 0.32 1.38e-7 Bronchopulmonary dysplasia; CESC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg18350739 chr11:68623251 NA -0.46 -6.84 -0.39 5.59e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs477692 0.685 rs534430 chr10:131398734 A/C cg05714579 chr10:131428358 MGMT 0.5 6.77 0.38 8.16e-11 Response to temozolomide; CESC cis rs4803468 0.967 rs13344547 chr19:41945848 G/T cg09537434 chr19:41945824 ATP5SL 1.06 19.91 0.77 1.51e-54 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05258477 chr6:170151703 C6orf70;TCTE3 0.58 6.47 0.37 4.58e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25802399 chr20:61847276 YTHDF1 0.62 7.26 0.41 4.4e-12 Gut microbiome composition (summer); CESC trans rs4950322 0.580 rs17355419 chr1:146581676 T/C cg04954894 chr8:38089920 DDHD2 -0.59 -6.42 -0.37 6.22e-10 Protein quantitative trait loci; CESC cis rs7561273 0.609 rs6720226 chr2:24295853 A/G cg20701182 chr2:24300061 SF3B14 0.46 6.14 0.35 2.93e-9 Quantitative traits; CESC cis rs941873 0.868 rs10740497 chr10:81126380 T/C cg09469691 chr10:81107165 PPIF 0.56 7.56 0.42 6.79e-13 Height; CESC cis rs2712184 0.756 rs2541395 chr2:217647675 C/T cg05032264 chr2:217675019 NA -0.34 -5.15 -0.3 5.03e-7 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs12478296 0.681 rs56357900 chr2:243033966 A/C cg06360820 chr2:242988706 NA -0.7 -7.82 -0.43 1.29e-13 Obesity-related traits; CESC trans rs10776614 0.799 rs1838569 chr10:49763677 A/C cg19218067 chr2:181235115 NA 0.5 6.1 0.35 3.7e-9 Self-employment; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05463257 chr3:182782445 MCCC1 0.46 6.44 0.37 5.66e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs877282 0.853 rs7083589 chr10:754494 G/A cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs72945132 0.825 rs947811 chr11:70209142 A/T cg00319359 chr11:70116639 PPFIA1 0.73 6.96 0.39 2.63e-11 Coronary artery disease; CESC cis rs11608355 0.515 rs7955932 chr12:109941303 G/A cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs2806561 0.765 rs652706 chr1:23514246 G/A cg12483005 chr1:23474871 LUZP1 0.38 6.0 0.35 6.44e-9 Height; CESC cis rs6546550 0.935 rs3214007 chr2:70098808 A/G cg02498382 chr2:70120550 SNRNP27 -0.38 -6.54 -0.37 3.2e-10 Prevalent atrial fibrillation; CESC cis rs1355223 0.506 rs6484738 chr11:34860858 C/T cg06937548 chr11:34938143 PDHX;APIP 0.41 5.1 0.3 6.58e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9287719 0.967 rs9287720 chr2:10752664 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC trans rs624896 0.661 rs163207 chr5:113725710 C/G cg24875808 chr15:86742911 AGBL1 0.71 6.13 0.35 3.19e-9 JT interval (sulfonylurea treatment interaction); CESC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg12193833 chr17:30244370 NA -0.72 -7.38 -0.41 2.07e-12 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06227920 chr15:65477998 CLPX 0.6 6.57 0.37 2.61e-10 Gut microbiome composition (summer); CESC cis rs4835473 0.800 rs1849133 chr4:144879415 C/T cg25736465 chr4:144833511 NA 0.4 5.99 0.35 6.7e-9 Immature fraction of reticulocytes; CESC cis rs3785574 0.743 rs2727334 chr17:61969063 A/T cg07677032 chr17:61819896 STRADA 0.43 5.42 0.32 1.35e-7 Height; CESC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg11764359 chr7:65958608 NA -0.94 -15.61 -0.69 2.13e-39 Aortic root size; CESC cis rs4810685 0.526 rs6018686 chr20:46410965 A/C cg08288986 chr20:46415360 SULF2 0.51 5.81 0.34 1.75e-8 Attention deficit hyperactivity disorder (time to onset); CESC cis rs11997175 0.655 rs72630922 chr8:33662401 G/A ch.8.33884649F chr8:33765107 NA 0.47 5.96 0.34 7.88e-9 Body mass index; CESC cis rs2279817 1.000 rs10788680 chr1:18019454 A/G cg21791023 chr1:18019539 ARHGEF10L 0.58 8.51 0.46 1.31e-15 Neuroticism; CESC cis rs2243480 1.000 rs160646 chr7:65556280 C/T cg12463550 chr7:65579703 CRCP 0.75 5.78 0.33 2.06e-8 Diabetic kidney disease; CESC cis rs9324022 0.722 rs111475476 chr14:101165917 C/T cg18089426 chr14:101175970 NA 0.55 5.64 0.33 4.41e-8 Plateletcrit; CESC cis rs425277 0.916 rs414777 chr1:2101687 G/A cg16545954 chr1:2118288 C1orf86 0.33 5.59 0.32 5.7e-8 Height; CESC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg19592336 chr6:28129416 ZNF389 0.61 7.97 0.44 4.74e-14 Depression; CESC cis rs57221529 0.766 rs12519469 chr5:581772 A/G cg16447950 chr5:562315 NA -0.6 -6.32 -0.36 1.09e-9 Lung disease severity in cystic fibrosis; CESC cis rs7927771 0.524 rs7936948 chr11:47704200 T/G cg20307385 chr11:47447363 PSMC3 0.61 8.46 0.46 1.87e-15 Subjective well-being; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg24859228 chr10:12391835 CAMK1D 0.59 6.04 0.35 5.18e-9 Diastolic blood pressure; CESC cis rs2075371 0.611 rs11762920 chr7:134018514 C/T cg20476274 chr7:133979776 SLC35B4 0.59 7.81 0.43 1.36e-13 Mean platelet volume; CESC cis rs2243480 1.000 rs316313 chr7:65593548 G/A cg13147721 chr7:65941812 NA -0.99 -9.4 -0.5 2.68e-18 Diabetic kidney disease; CESC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.08e-10 Bipolar disorder; CESC trans rs7945404 0.548 rs10750188 chr11:121230246 A/C cg09432902 chr12:113909932 LHX5 0.45 6.08 0.35 4.23e-9 QT interval; CESC cis rs1153858 0.943 rs7402632 chr15:45701913 A/T cg14582100 chr15:45693742 SPATA5L1 0.41 5.79 0.34 1.97e-8 Homoarginine levels; CESC cis rs6466055 0.720 rs12334245 chr7:104995627 T/C cg04380332 chr7:105027541 SRPK2 -0.42 -5.54 -0.32 7.45e-8 Schizophrenia; CESC cis rs35123781 0.696 rs7703195 chr5:139071632 G/A cg10513866 chr5:139070639 NA 0.45 6.37 0.36 8.36e-10 Schizophrenia; CESC cis rs4474465 0.850 rs10899536 chr11:78216992 C/A cg27205649 chr11:78285834 NARS2 0.44 5.35 0.31 1.94e-7 Alzheimer's disease (survival time); CESC trans rs6089829 0.962 rs11086151 chr20:61664644 C/T cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs12410462 0.681 rs75876430 chr1:227661157 A/G cg23173402 chr1:227635558 NA 0.68 5.93 0.34 9.49e-9 Major depressive disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12427896 chr2:111880694 BCL2L11 -0.45 -6.67 -0.38 1.45e-10 Gambling; CESC cis rs9581857 1.000 rs9581857 chr13:28027714 A/C cg01674679 chr13:27998804 GTF3A -0.67 -5.29 -0.31 2.58e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs9291683 0.546 rs7442336 chr4:10045783 G/A cg11266682 chr4:10021025 SLC2A9 0.65 12.28 0.6 9.38e-28 Bone mineral density; CESC cis rs10206020 0.885 rs11885392 chr2:1578182 C/A cg12573674 chr2:1569213 NA -0.45 -5.18 -0.3 4.5e-7 IgG glycosylation; CESC cis rs7666738 0.830 rs4699580 chr4:98930673 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC cis rs74181299 0.684 rs6756585 chr2:65340070 G/A cg05010058 chr2:65284262 CEP68 -0.31 -5.07 -0.3 7.51e-7 Pulse pressure; CESC cis rs2273669 0.667 rs76747161 chr6:109305456 G/A cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.74 -0.33 2.55e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs4979906 1.000 rs11002246 chr10:79446777 T/A cg00983440 chr10:79422392 NA -0.48 -5.08 -0.3 7.19e-7 Mortality in heart failure; CESC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.29e-7 Life satisfaction; CESC cis rs11155671 0.530 rs9371544 chr6:150217360 A/G cg09699651 chr6:150184138 LRP11 0.54 7.62 0.42 4.61e-13 Testicular germ cell tumor; CESC cis rs12711979 0.765 rs10208316 chr2:3827630 T/C cg17052675 chr2:3827356 NA -0.42 -6.72 -0.38 1.12e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs9790314 0.967 rs1382427 chr3:161032576 T/C cg04691961 chr3:161091175 C3orf57 -0.43 -5.56 -0.32 6.47e-8 Morning vs. evening chronotype; CESC cis rs7592578 0.640 rs56127319 chr2:191296429 G/A cg27211696 chr2:191398769 TMEM194B -0.6 -6.08 -0.35 4.21e-9 Diastolic blood pressure; CESC cis rs2898681 0.618 rs7677726 chr4:53739262 A/G cg00791764 chr4:53727839 RASL11B -0.55 -5.34 -0.31 1.98e-7 Optic nerve measurement (cup area); CESC cis rs7809950 1.000 rs2894475 chr7:107262558 A/T cg23024343 chr7:107201750 COG5 -0.42 -5.81 -0.34 1.79e-8 Coronary artery disease; CESC cis rs2072732 0.861 rs12036378 chr1:2955158 G/A cg03976712 chr1:2946727 NA 0.33 5.53 0.32 7.83e-8 Plateletcrit; CESC cis rs1050631 0.564 rs1785905 chr18:33713287 T/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.51e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.38 0.54 2.06e-21 Prudent dietary pattern; CESC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg07507251 chr3:52567010 NT5DC2 0.37 6.1 0.35 3.82e-9 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19008789 chr15:55700587 CCPG1 0.58 6.14 0.35 3e-9 Gut microbiome composition (summer); CESC cis rs7116495 1.000 rs656640 chr11:71781710 T/C cg10381502 chr11:71823885 C11orf51 -0.68 -5.48 -0.32 9.68e-8 Severe influenza A (H1N1) infection; CESC cis rs3733585 0.664 rs17185870 chr4:9958214 C/A cg11266682 chr4:10021025 SLC2A9 -0.6 -11.12 -0.56 7.79e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs55728055 0.661 rs55673702 chr22:32035518 G/A cg01338084 chr22:32026380 PISD 1.22 8.7 0.47 3.47e-16 Age-related hearing impairment; CESC cis rs9611565 0.765 rs202663 chr22:41812819 T/C cg06481639 chr22:41940642 POLR3H 0.61 6.45 0.37 5.35e-10 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04800682 chr3:58223165 ABHD6 -0.58 -6.9 -0.39 3.74e-11 Gut microbiome composition (summer); CESC cis rs10206020 0.759 rs11903889 chr2:1576601 C/T cg12573674 chr2:1569213 NA -0.46 -5.2 -0.3 3.96e-7 IgG glycosylation; CESC cis rs7408868 0.908 rs10416865 chr19:15277601 T/C cg14696996 chr19:15285081 NOTCH3 1.11 11.94 0.59 1.43e-26 Pulse pressure; CESC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg02951883 chr7:2050386 MAD1L1 -0.51 -6.76 -0.38 8.53e-11 Bipolar disorder and schizophrenia; CESC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg12963246 chr6:28129442 ZNF389 0.39 5.6 0.33 5.36e-8 Parkinson's disease; CESC cis rs763121 0.853 rs2267395 chr22:39113903 C/T cg21395723 chr22:39101663 GTPBP1 0.51 7.08 0.4 1.33e-11 Menopause (age at onset); CESC cis rs962856 0.575 rs588779 chr2:67665951 C/T cg09028215 chr2:67624308 ETAA1 -0.44 -5.35 -0.31 1.93e-7 Pancreatic cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04662649 chr15:41191689 VPS18 -0.6 -7.19 -0.4 6.66e-12 Gut microbiome composition (summer); CESC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg21138405 chr5:131827807 IRF1 -0.4 -5.82 -0.34 1.72e-8 Breast cancer;Mosquito bite size; CESC cis rs6542838 0.553 rs6739503 chr2:99537295 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.43 -5.51 -0.32 8.69e-8 Fear of minor pain; CESC cis rs8058578 1.000 rs3747481 chr16:30666367 C/T cg02466173 chr16:30829666 NA -0.46 -7.33 -0.41 2.73e-12 Multiple myeloma; CESC cis rs796364 0.901 rs35572201 chr2:201035093 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -6.44 -0.37 5.65e-10 Schizophrenia; CESC cis rs72634258 0.554 rs35123409 chr1:7878568 C/T cg26816564 chr1:7831052 VAMP3 0.63 5.56 0.32 6.42e-8 Inflammatory bowel disease; CESC cis rs3026101 0.624 rs7426 chr17:5288983 T/C cg24500398 chr17:5266808 RABEP1 -0.42 -6.03 -0.35 5.43e-9 Body mass index; CESC trans rs62110082 0.522 rs12459126 chr19:52332884 G/C cg18094401 chr15:25434150 SNORD115-29;SNORD115-36;SNORD115-43;SNORD115-11 -0.58 -6.37 -0.36 8.23e-10 Bipolar disorder (body mass index interaction); CESC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.63 0.51 5.12e-19 Platelet count; CESC cis rs11098499 0.955 rs13113112 chr4:120156040 C/T cg24375607 chr4:120327624 NA 0.42 5.09 0.3 6.73e-7 Corneal astigmatism; CESC cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg07697082 chr8:82753677 SNX16 0.37 5.16 0.3 4.74e-7 Diastolic blood pressure; CESC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg19500275 chr17:80737654 TBCD 0.48 5.49 0.32 9.19e-8 Glycated hemoglobin levels; CESC cis rs7927771 1.000 rs10838748 chr11:47716381 T/G cg18512352 chr11:47633146 NA -0.6 -9.5 -0.5 1.34e-18 Subjective well-being; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04524006 chr5:111093197 C5orf13 0.46 6.1 0.35 3.82e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2228479 0.850 rs62054638 chr16:89821131 G/C cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs6815814 0.768 rs6851685 chr4:38893843 G/T cg02016764 chr4:38805732 TLR1 -0.52 -6.88 -0.39 4.41e-11 Breast cancer; CESC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg12463550 chr7:65579703 CRCP 0.51 6.41 0.37 6.58e-10 Aortic root size; CESC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.07 0.53 2.16e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg08470875 chr2:26401718 FAM59B 0.45 5.07 0.3 7.49e-7 Gut microbiome composition (summer); CESC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg19500275 chr17:80737654 TBCD 0.66 6.7 0.38 1.25e-10 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs7216064 1.000 rs9915108 chr17:65874463 T/C cg07042672 chr17:66097459 LOC651250 -0.56 -6.5 -0.37 3.96e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11252926 0.674 rs11598550 chr10:504778 A/C cg00953403 chr17:74099816 EXOC7 -0.51 -6.39 -0.37 7.44e-10 Psychosis in Alzheimer's disease; CESC cis rs11676348 0.776 rs11690316 chr2:219017462 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.0 -0.35 6.34e-9 Ulcerative colitis; CESC cis rs73001065 0.818 rs12610185 chr19:19721722 G/A cg03709012 chr19:19516395 GATAD2A 0.96 6.02 0.35 5.77e-9 LDL cholesterol; CESC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg09359103 chr1:154839909 KCNN3 -0.65 -12.31 -0.6 7.76e-28 Prostate cancer; CESC cis rs3820068 0.580 rs34426856 chr1:16006315 C/T cg18133145 chr1:16060689 PLEKHM2 -0.42 -5.16 -0.3 4.75e-7 Systolic blood pressure; CESC cis rs727563 0.593 rs132770 chr22:42017264 A/G cg17376030 chr22:41985996 PMM1 -0.83 -9.11 -0.49 2.06e-17 Crohn's disease;Inflammatory bowel disease; CESC cis rs9348721 0.673 rs9358934 chr6:26363755 G/C cg14345882 chr6:26364793 BTN3A2 0.62 6.53 0.37 3.29e-10 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg25072359 chr17:41440525 NA -0.47 -6.28 -0.36 1.35e-9 Menopause (age at onset); CESC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg08859206 chr1:53392774 SCP2 -0.56 -7.35 -0.41 2.49e-12 Monocyte count; CESC cis rs7845219 0.544 rs2123647 chr8:95931782 A/G cg16049864 chr8:95962084 TP53INP1 0.48 7.16 0.4 7.86e-12 Type 2 diabetes; CESC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg02725872 chr8:58115012 NA -0.44 -6.89 -0.39 3.94e-11 Developmental language disorder (linguistic errors); CESC cis rs11792861 0.641 rs10979586 chr9:111647764 C/T cg05043794 chr9:111880884 C9orf5 -0.31 -5.04 -0.3 8.79e-7 Menarche (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18163227 chr17:74554350 SNORD1C 0.45 6.19 0.36 2.3e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611519 0.929 rs11090039 chr22:41496800 G/A cg03806693 chr22:41940476 POLR3H -0.6 -5.92 -0.34 1.01e-8 Neuroticism; CESC cis rs11098499 0.604 rs2389886 chr4:120570422 C/T cg24375607 chr4:120327624 NA 0.42 5.16 0.3 4.78e-7 Corneal astigmatism; CESC cis rs28830936 0.966 rs17678552 chr15:42066190 T/C cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.41 -5.81 -0.34 1.77e-8 Diastolic blood pressure; CESC cis rs1577917 0.916 rs12203358 chr6:86603224 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -5.62 -0.33 4.9e-8 Response to antipsychotic treatment; CESC cis rs2070488 0.965 rs7642472 chr3:38525567 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.96 17.81 0.74 3.3e-47 Electrocardiographic conduction measures; CESC cis rs6060717 0.536 rs17431878 chr20:34502107 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -6.93 -0.39 3.22e-11 Hip circumference adjusted for BMI; CESC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.07 -0.35 4.36e-9 Menopause (age at onset); CESC cis rs9902453 0.933 rs4470197 chr17:28464474 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.59 0.42 5.29e-13 Coffee consumption (cups per day); CESC cis rs17376456 0.825 rs13161885 chr5:93071242 A/C cg25358565 chr5:93447407 FAM172A 1.15 10.72 0.55 1.63e-22 Diabetic retinopathy; CESC cis rs1355223 0.934 rs5010670 chr11:34766649 A/C cg11058730 chr11:34937778 PDHX;APIP -0.44 -5.74 -0.33 2.62e-8 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6088580 0.668 rs1205337 chr20:32926041 T/A cg06115741 chr20:33292138 TP53INP2 -0.45 -5.67 -0.33 3.79e-8 Glomerular filtration rate (creatinine); CESC cis rs6736093 0.966 rs11674226 chr2:112698388 G/A cg12686935 chr2:112915763 FBLN7 -0.43 -5.56 -0.32 6.75e-8 Coronary artery disease; CESC cis rs911555 0.755 rs1138400 chr14:103956833 A/G cg24130564 chr14:104152367 KLC1 -0.5 -6.58 -0.37 2.56e-10 Intelligence (multi-trait analysis); CESC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg02951883 chr7:2050386 MAD1L1 -0.46 -5.92 -0.34 9.71e-9 Bipolar disorder and schizophrenia; CESC cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg26769984 chr7:1090371 C7orf50 0.48 5.1 0.3 6.52e-7 Bronchopulmonary dysplasia; CESC cis rs8062405 0.573 rs11645306 chr16:28983936 G/C cg05966235 chr16:28915196 ATP2A1 -0.4 -5.69 -0.33 3.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs796364 1.000 rs71424239 chr2:200725473 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.9 -7.17 -0.4 7.55e-12 Schizophrenia; CESC cis rs7020830 0.516 rs36047049 chr9:37375472 G/T cg14294708 chr9:37120828 ZCCHC7 1.01 12.05 0.59 6.02e-27 Schizophrenia; CESC cis rs5760092 0.755 rs4585126 chr22:24270005 T/C cg23131131 chr22:24373011 LOC391322 0.6 7.48 0.42 1.13e-12 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg11663144 chr21:46675770 NA -0.64 -10.05 -0.53 2.34e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg19318889 chr4:1322082 MAEA 0.56 6.8 0.39 6.86e-11 Longevity; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12843872 chr7:90894352 FZD1 -0.46 -6.75 -0.38 9.22e-11 Gambling; CESC cis rs854765 1.000 rs854765 chr17:18012730 T/C cg16928487 chr17:17741425 SREBF1 0.58 9.51 0.5 1.26e-18 Total body bone mineral density; CESC cis rs2120019 1.000 rs35736167 chr15:75332002 T/G cg17294928 chr15:75287854 SCAMP5 -0.74 -8.31 -0.45 5.03e-15 Blood trace element (Zn levels); CESC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg16680214 chr1:154839983 KCNN3 -0.54 -8.51 -0.46 1.33e-15 Prostate cancer; CESC cis rs950776 0.752 rs2869546 chr15:78907345 C/T cg06917634 chr15:78832804 PSMA4 -0.56 -6.84 -0.39 5.33e-11 Sudden cardiac arrest; CESC cis rs7927771 0.524 rs4539273 chr11:47694699 C/T cg20307385 chr11:47447363 PSMC3 -0.58 -8.03 -0.44 3.1e-14 Subjective well-being; CESC cis rs4472734 0.965 rs4259615 chr1:214628959 C/G cg00063699 chr1:214624242 PTPN14 -0.33 -5.04 -0.3 8.73e-7 Height; CESC cis rs2997447 0.655 rs12059101 chr1:26384013 A/G cg19633962 chr1:26362018 EXTL1 -0.54 -5.43 -0.32 1.27e-7 QRS complex (12-leadsum); CESC cis rs7635838 0.751 rs6442260 chr3:11590751 C/T cg00170343 chr3:11313890 ATG7 -0.46 -5.95 -0.34 8.25e-9 HDL cholesterol; CESC cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg21782813 chr7:2030301 MAD1L1 0.41 5.75 0.33 2.45e-8 Schizophrenia; CESC cis rs9926296 0.656 rs7191144 chr16:89823393 C/T cg27121462 chr16:89883253 FANCA 0.54 6.9 0.39 3.81e-11 Vitiligo; CESC cis rs11711311 1.000 rs10934243 chr3:113430239 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.69 9.69 0.51 3.42e-19 IgG glycosylation; CESC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg24675658 chr1:53192096 ZYG11B 0.77 11.82 0.59 3.51e-26 Monocyte count; CESC cis rs9291683 0.566 rs13122689 chr4:10044648 A/G cg00071950 chr4:10020882 SLC2A9 0.81 13.65 0.64 1.7e-32 Bone mineral density; CESC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg22143856 chr6:28129313 ZNF389 0.51 6.62 0.38 2e-10 Depression; CESC cis rs3126085 0.877 rs4456097 chr1:152229741 G/A cg03465714 chr1:152285911 FLG -0.44 -5.45 -0.32 1.15e-7 Atopic dermatitis; CESC cis rs13191362 1.000 rs34619021 chr6:163029767 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.51 5.53 0.32 7.85e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs9325144 0.600 rs1817648 chr12:38733424 C/T cg23762105 chr12:34175262 ALG10 0.44 6.01 0.35 6.13e-9 Morning vs. evening chronotype; CESC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg00166722 chr3:10149974 C3orf24 0.46 5.89 0.34 1.18e-8 Alzheimer's disease; CESC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg25767906 chr1:53392781 SCP2 0.44 6.07 0.35 4.34e-9 Monocyte count; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10709532 chr8:145654026 VPS28 0.45 6.21 0.36 2e-9 Systemic lupus erythematosus; CESC cis rs2109514 1.000 rs2109514 chr7:116159961 G/A cg12739419 chr7:116140593 CAV2 -0.36 -6.55 -0.37 3.02e-10 Prevalent atrial fibrillation; CESC cis rs881375 0.967 rs1930781 chr9:123687834 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.08 0.3 7.23e-7 Rheumatoid arthritis; CESC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg27494647 chr7:150038898 RARRES2 0.44 5.19 0.3 4.17e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs854765 0.647 rs9303144 chr17:17977355 T/C cg04398451 chr17:18023971 MYO15A -0.78 -11.51 -0.58 4.01e-25 Total body bone mineral density; CESC cis rs7216064 0.953 rs4791046 chr17:65851973 G/A cg07042672 chr17:66097459 LOC651250 -0.55 -6.23 -0.36 1.82e-9 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs858239 0.799 rs10279941 chr7:23370508 C/G cg23682824 chr7:23144976 KLHL7 0.42 5.44 0.32 1.2e-7 Cerebrospinal fluid biomarker levels; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg25987502 chr17:6899865 ALOX12 0.45 7.47 0.42 1.16e-12 Tonsillectomy; CESC trans rs61931739 0.517 rs11513277 chr12:34074799 G/T cg26384229 chr12:38710491 ALG10B 0.6 8.38 0.46 3.22e-15 Morning vs. evening chronotype; CESC cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg02773041 chr1:40204384 PPIE 0.53 7.52 0.42 8.54e-13 Blood protein levels; CESC cis rs11785400 1.000 rs4557682 chr8:143738182 T/C cg24634471 chr8:143751801 JRK 0.47 6.21 0.36 2e-9 Schizophrenia; CESC cis rs7267979 0.903 rs6115109 chr20:25239667 G/A cg08601574 chr20:25228251 PYGB 0.42 5.92 0.34 1.01e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs6088580 0.660 rs6059893 chr20:33105897 T/G cg24642439 chr20:33292090 TP53INP2 0.5 6.54 0.37 3.14e-10 Glomerular filtration rate (creatinine); CESC cis rs6088580 0.634 rs6120650 chr20:33039973 G/A cg06115741 chr20:33292138 TP53INP2 0.47 6.1 0.35 3.84e-9 Glomerular filtration rate (creatinine); CESC cis rs2250402 0.510 rs8031319 chr15:40323692 A/G cg10636054 chr15:40330586 SRP14 1.01 7.46 0.42 1.23e-12 Corneal curvature; CESC cis rs7771547 0.542 rs597153 chr6:36395997 C/T cg07856975 chr6:36356162 ETV7 0.36 5.38 0.31 1.67e-7 Platelet distribution width; CESC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg04369109 chr6:150039330 LATS1 -0.39 -5.28 -0.31 2.71e-7 Lung cancer; CESC cis rs6690583 0.623 rs74689037 chr1:85439268 C/T cg22153463 chr1:85462885 MCOLN2 0.77 7.26 0.41 4.31e-12 Serum sulfate level; CESC cis rs11098499 0.908 rs7695996 chr4:120322033 C/T cg24375607 chr4:120327624 NA 0.48 5.87 0.34 1.28e-8 Corneal astigmatism; CESC cis rs6484504 0.600 rs7122895 chr11:31346620 G/C cg14844989 chr11:31128820 NA 0.39 5.51 0.32 8.43e-8 Red blood cell count; CESC cis rs9457247 1.000 rs398278 chr6:167388169 A/G cg23791538 chr6:167370224 RNASET2 -0.61 -8.55 -0.47 9.66e-16 Crohn's disease; CESC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg22029157 chr1:209979665 IRF6 0.76 8.7 0.47 3.54e-16 Cleft lip with or without cleft palate; CESC cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg26874164 chr19:58962979 ZNF324B -0.52 -7.42 -0.41 1.61e-12 Uric acid clearance; CESC cis rs2950393 0.895 rs2958123 chr12:57062225 A/G cg05584118 chr12:57595605 LRP1 -0.36 -5.21 -0.3 3.84e-7 Platelet distribution width; CESC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.9e-10 Bipolar disorder; CESC cis rs7000551 0.751 rs2443505 chr8:22375341 G/A cg12081754 chr8:22256438 SLC39A14 0.42 5.63 0.33 4.6e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs11167764 1.000 rs6580220 chr5:141480558 G/A cg08523384 chr5:141488047 NDFIP1 -0.38 -5.64 -0.33 4.34e-8 Crohn's disease; CESC cis rs28673728 0.897 rs28391281 chr1:38408974 T/C cg04673462 chr1:38461896 NA 0.39 5.92 0.34 9.68e-9 Red cell distribution width; CESC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg19077165 chr18:44547161 KATNAL2 -0.61 -9.16 -0.49 1.5e-17 Personality dimensions; CESC cis rs10845606 1.000 rs10845606 chr12:12834894 G/T cg04607235 chr12:12878440 APOLD1 -0.71 -8.02 -0.44 3.43e-14 Systemic lupus erythematosus; CESC cis rs35306767 0.953 rs12357633 chr10:957246 C/T cg10556349 chr10:835070 NA 0.66 6.32 0.36 1.08e-9 Eosinophil percentage of granulocytes; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg02106828 chr1:236959224 MTR -0.45 -6.03 -0.35 5.52e-9 Recombination measurement; CESC cis rs2204008 0.837 rs11612397 chr12:38357455 T/C cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.62e-9 Bladder cancer; CESC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg05373962 chr22:49881684 NA -0.38 -6.61 -0.38 2.12e-10 Monocyte count;Monocyte percentage of white cells; CESC cis rs11690935 0.959 rs6759575 chr2:172689068 C/T cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.52 -0.67 1.55e-35 Schizophrenia; CESC cis rs6570726 0.902 rs973855 chr6:145781850 C/T cg05347473 chr6:146136440 FBXO30 -0.41 -5.63 -0.33 4.47e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1670533 0.932 rs10902753 chr4:1056223 G/A cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.7e-7 Recombination rate (females); CESC trans rs6818288 0.778 rs12512013 chr4:30077820 A/G cg12528397 chr3:62933670 NA 0.42 6.13 0.35 3.2e-9 Obesity-related traits; CESC cis rs472402 0.580 rs7706809 chr5:6635971 G/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.54 -7.32 -0.41 2.92e-12 Response to amphetamines; CESC cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg20503657 chr10:835505 NA 0.71 6.7 0.38 1.23e-10 Eosinophil percentage of granulocytes; CESC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg26314531 chr2:26401878 FAM59B -0.76 -8.68 -0.47 3.98e-16 Gut microbiome composition (summer); CESC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg00769240 chr8:12517080 NA -0.44 -6.02 -0.35 5.7e-9 Blood pressure (smoking interaction); CESC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg05552183 chr6:42928497 GNMT 0.76 11.55 0.58 2.9e-25 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2050392 0.517 rs589980 chr10:30756385 T/A cg18806716 chr10:30721971 MAP3K8 -0.46 -7.07 -0.4 1.34e-11 Inflammatory bowel disease; CESC cis rs10851478 0.872 rs12908635 chr15:49855920 A/G cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC trans rs61931739 0.817 rs1687002 chr12:34170263 T/C cg26384229 chr12:38710491 ALG10B 0.47 6.5 0.37 3.94e-10 Morning vs. evening chronotype; CESC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg03351412 chr1:154909251 PMVK -0.61 -7.73 -0.43 2.28e-13 Prostate cancer; CESC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg13206674 chr6:150067644 NUP43 0.45 6.44 0.37 5.65e-10 Lung cancer; CESC cis rs7772486 0.846 rs9403767 chr6:146402386 G/T cg23711669 chr6:146136114 FBXO30 0.89 13.02 0.62 2.64e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs1008375 0.966 rs6449330 chr4:17703949 C/T cg02297831 chr4:17616191 MED28 -0.41 -5.04 -0.3 8.57e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1670533 1.000 rs10084888 chr4:1053814 G/T cg04106633 chr4:1044584 NA 0.41 5.2 0.3 3.94e-7 Recombination rate (females); CESC cis rs6736093 0.932 rs17174697 chr2:112662914 A/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.17 -0.3 4.56e-7 Coronary artery disease; CESC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg08027265 chr7:2291960 NA -0.45 -7.1 -0.4 1.15e-11 Bipolar disorder and schizophrenia; CESC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg09177884 chr7:1199841 ZFAND2A -0.47 -5.93 -0.34 9.38e-9 Longevity;Endometriosis; CESC cis rs733175 0.855 rs10023068 chr4:10004832 C/T cg00071950 chr4:10020882 SLC2A9 -0.56 -6.45 -0.37 5.14e-10 Psychosis and Alzheimer's disease; CESC trans rs561341 1.000 rs4795669 chr17:30244701 C/T cg27661571 chr11:113659931 NA -0.69 -6.95 -0.39 2.88e-11 Hip circumference adjusted for BMI; CESC cis rs1577917 0.958 rs11756510 chr6:86699794 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -5.99 -0.35 6.9e-9 Response to antipsychotic treatment; CESC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg09323728 chr8:95962352 TP53INP1 0.36 6.98 0.39 2.32e-11 Type 2 diabetes; CESC cis rs6912958 0.781 rs4707376 chr6:88270947 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.5 -0.37 3.95e-10 Monocyte percentage of white cells; CESC cis rs2204008 0.639 rs7311462 chr12:38278130 G/A cg13010199 chr12:38710504 ALG10B 0.52 6.38 0.36 8.04e-10 Bladder cancer; CESC cis rs35740288 0.721 rs17637276 chr15:86243520 T/C cg20737812 chr15:86336631 KLHL25 -0.38 -5.1 -0.3 6.57e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs9291683 0.552 rs11736410 chr4:10017241 G/A cg00071950 chr4:10020882 SLC2A9 0.91 17.5 0.73 4.21e-46 Bone mineral density; CESC cis rs950169 1.000 rs950169 chr15:84706461 C/T cg17507749 chr15:85114479 UBE2QP1 0.64 6.92 0.39 3.47e-11 Schizophrenia; CESC cis rs6547741 1.000 rs6756238 chr2:27841305 G/A cg27432699 chr2:27873401 GPN1 0.49 6.82 0.39 6.31e-11 Oral cavity cancer; CESC cis rs2734839 0.537 rs11214603 chr11:113279922 G/A cg14159747 chr11:113255604 NA 0.36 6.52 0.37 3.63e-10 Information processing speed; CESC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg10792982 chr14:105748885 BRF1 0.4 5.04 0.3 8.82e-7 Mean platelet volume;Platelet distribution width; CESC cis rs75804782 0.521 rs2117691 chr2:239414734 C/T cg18131467 chr2:239335373 ASB1 -0.66 -5.29 -0.31 2.58e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs7191439 0.728 rs8043637 chr16:88781125 T/C cg02389323 chr16:88786976 FAM38A 0.83 6.87 0.39 4.62e-11 Plateletcrit; CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg07308232 chr7:1071921 C7orf50 -0.41 -5.45 -0.32 1.15e-7 Longevity;Endometriosis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14797438 chr18:9615155 PPP4R1 -0.41 -6.03 -0.35 5.4e-9 Gambling; CESC cis rs12142240 0.660 rs7520497 chr1:46824919 C/A cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs10484885 0.824 rs72919982 chr6:90532600 C/G cg13799429 chr6:90582589 CASP8AP2 -0.76 -6.94 -0.39 3e-11 QRS interval (sulfonylurea treatment interaction); CESC cis rs12472274 0.941 rs11677230 chr2:239092054 T/C cg17459225 chr2:239074497 NA 0.58 8.29 0.45 5.7e-15 Phospholipid levels (plasma); CESC cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg12292205 chr6:26970375 C6orf41 -0.53 -5.75 -0.33 2.45e-8 Intelligence (multi-trait analysis); CESC cis rs6951245 0.542 rs28460147 chr7:1217192 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.47 -5.56 -0.32 6.51e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs116095464 0.614 rs10067482 chr5:219328 T/G cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.74 0.33 2.63e-8 Breast cancer; CESC cis rs67311347 0.955 rs60554147 chr3:40472503 T/C cg24209194 chr3:40518798 ZNF619 0.47 6.11 0.35 3.6e-9 Renal cell carcinoma; CESC cis rs9399135 0.967 rs9402676 chr6:135355507 C/T cg22676075 chr6:135203613 NA 0.51 7.3 0.41 3.39e-12 Red blood cell count; CESC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg14393609 chr7:65229607 NA -0.52 -7.15 -0.4 8.31e-12 Aortic root size; CESC cis rs3793683 0.520 rs4880426 chr10:134590610 G/A cg27286337 chr10:134555280 INPP5A 0.64 7.34 0.41 2.55e-12 Migraine; CESC trans rs62103177 0.810 rs62103178 chr18:77624555 C/G cg05926928 chr17:57297772 GDPD1 1.18 10.14 0.53 1.27e-20 Opioid sensitivity; CESC cis rs9863706 0.619 rs920289 chr3:72504422 G/A cg22685502 chr3:72496851 RYBP -0.26 -5.4 -0.31 1.51e-7 Height; CESC cis rs738322 0.935 rs75387 chr22:38572057 C/T cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC cis rs9788682 0.747 rs3743078 chr15:78894759 C/G cg24631222 chr15:78858424 CHRNA5 -0.79 -9.93 -0.52 5.97e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17198369 chr8:144883931 SCRIB 0.45 6.43 0.37 6.01e-10 Fibrinogen levels; CESC cis rs1552244 0.554 rs2272120 chr3:10046703 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -7.26 -0.41 4.31e-12 Alzheimer's disease; CESC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg04369109 chr6:150039330 LATS1 -0.43 -5.91 -0.34 1.05e-8 Lung cancer; CESC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg12311346 chr5:56204834 C5orf35 -0.41 -5.15 -0.3 5.08e-7 Coronary artery disease; CESC cis rs17253792 0.822 rs111467375 chr14:56046159 T/G cg24579896 chr14:56047964 C14orf33;KTN1 0.85 5.74 0.33 2.53e-8 Putamen volume; CESC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg26338869 chr17:61819248 STRADA 0.68 9.16 0.49 1.42e-17 Prudent dietary pattern; CESC cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.738 rs34965784 chr4:120361586 G/C cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs7208859 0.673 rs28588622 chr17:29245699 G/A cg19761014 chr17:28927070 LRRC37B2 0.7 5.64 0.33 4.47e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs72781680 0.652 rs12618900 chr2:23910775 C/T cg20701182 chr2:24300061 SF3B14 0.78 6.38 0.36 7.87e-10 Lymphocyte counts; CESC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg13944838 chr5:179740914 GFPT2 0.61 8.26 0.45 6.96e-15 Height; CESC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg20225915 chr11:805726 LRDD 0.3 5.1 0.3 6.39e-7 Breast cancer; CESC cis rs6998277 1.000 rs35155104 chr8:103646559 G/T cg10187029 chr8:103597600 NA 0.57 6.44 0.37 5.46e-10 Migraine; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg09737314 chr17:6899359 ALOX12 -0.4 -6.48 -0.37 4.35e-10 Tonsillectomy; CESC cis rs2262909 0.893 rs4244912 chr19:22203237 T/A cg11619707 chr19:22235551 ZNF257 -0.35 -5.69 -0.33 3.31e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg03352830 chr11:487213 PTDSS2 0.74 7.19 0.4 6.72e-12 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09779924 chr19:2755476 SGTA -0.65 -7.59 -0.42 5.48e-13 Gut microbiome composition (summer); CESC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.53 -0.32 7.56e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1843834 0.898 rs4674936 chr2:225553731 C/T cg22455342 chr2:225449267 CUL3 0.53 6.56 0.37 2.86e-10 IgE levels in asthmatics (D.p. specific); CESC cis rs1372520 1.000 rs1372520 chr4:90757505 T/C cg15133208 chr4:90757351 SNCA -0.38 -5.12 -0.3 5.78e-7 Neuroticism; CESC cis rs9611565 0.592 rs5996037 chr22:41965292 A/G cg06481639 chr22:41940642 POLR3H -0.59 -6.48 -0.37 4.52e-10 Vitiligo; CESC cis rs12900413 0.687 rs13343250 chr15:90311410 T/C cg24249390 chr15:90295951 MESP1 -0.41 -5.61 -0.33 5.06e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs644799 1.000 rs564675 chr11:95561873 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.76 0.38 8.51e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg15017067 chr4:17643749 FAM184B 0.37 5.2 0.3 3.95e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6963495 0.818 rs56055535 chr7:105163574 C/A cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs1018836 0.608 rs12679836 chr8:91465287 A/G cg16814680 chr8:91681699 NA -0.52 -7.31 -0.41 3.08e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg02487422 chr3:49467188 NICN1 0.44 5.57 0.32 6.38e-8 Parkinson's disease; CESC cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.22 0.41 5.44e-12 Tonsillectomy; CESC cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg03060546 chr3:49711283 APEH 0.53 6.31 0.36 1.19e-9 Parkinson's disease; CESC cis rs1707322 0.721 rs4415615 chr1:46132109 C/T cg03146154 chr1:46216737 IPP 0.82 11.51 0.58 3.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1008375 1.000 rs10939756 chr4:17693867 C/T cg02297831 chr4:17616191 MED28 0.45 5.54 0.32 7.44e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs977987 0.806 rs34021527 chr16:75474090 A/G cg03315344 chr16:75512273 CHST6 0.43 6.12 0.35 3.35e-9 Dupuytren's disease; CESC cis rs7130144 0.541 rs57632525 chr11:130463168 C/G cg26307797 chr11:130446613 NA -0.74 -6.5 -0.37 3.95e-10 Urate levels in lean individuals; CESC cis rs9300255 0.770 rs7980687 chr12:123822711 G/A cg19016782 chr12:123741754 C12orf65 0.43 5.4 0.31 1.51e-7 Neutrophil percentage of white cells; CESC cis rs4819052 0.679 rs2255761 chr21:46683622 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 12.83 0.62 1.28e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2228479 0.850 rs62056091 chr16:89930414 G/A cg04013166 chr16:89971882 TCF25 0.73 5.99 0.35 6.99e-9 Skin colour saturation; CESC cis rs10242455 0.702 rs28377312 chr7:98984213 G/A cg25640893 chr7:99214727 ZNF498 1.07 6.45 0.37 5.2e-10 Blood metabolite levels; CESC cis rs6460942 0.514 rs118124486 chr7:12470381 T/G cg06484146 chr7:12443880 VWDE -0.54 -8.42 -0.46 2.42e-15 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16079358 chr14:23340577 LRP10 -0.55 -6.0 -0.35 6.53e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg23711669 chr6:146136114 FBXO30 -1.0 -15.71 -0.69 9.49e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs6964587 0.967 rs2188153 chr7:91595117 G/T cg17063962 chr7:91808500 NA 0.57 7.76 0.43 1.79e-13 Breast cancer; CESC cis rs5769765 0.908 rs4058453 chr22:50250297 T/C cg02269571 chr22:50332266 NA 0.47 5.45 0.32 1.15e-7 Schizophrenia; CESC cis rs66573146 1.000 rs28384174 chr4:6961107 G/T cg00086871 chr4:6988644 TBC1D14 1.09 6.61 0.38 2.14e-10 Granulocyte percentage of myeloid white cells; CESC cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7568458 0.684 rs1048740 chr2:85764966 A/T cg02493740 chr2:85810744 VAMP5 -0.57 -8.34 -0.46 4.23e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs7103648 0.669 rs12577383 chr11:47774238 C/T cg20307385 chr11:47447363 PSMC3 0.8 12.17 0.6 2.22e-27 Diastolic blood pressure;Systolic blood pressure; CESC cis rs7772486 0.875 rs9322043 chr6:146352690 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.36 0.36 8.75e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6582630 0.560 rs11504462 chr12:38440379 G/A cg26384229 chr12:38710491 ALG10B -0.41 -5.49 -0.32 9.35e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs7000551 0.508 rs11780977 chr8:22245028 G/A cg12081754 chr8:22256438 SLC39A14 0.91 12.46 0.61 2.26e-28 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs56104184 0.775 rs56349331 chr19:49403009 T/A cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs12973672 0.855 rs7256866 chr19:35771257 A/G cg12095397 chr19:35769544 USF2 0.54 7.35 0.41 2.49e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4654899 0.865 rs10916927 chr1:21385795 T/C cg05370193 chr1:21551575 ECE1 0.42 6.32 0.36 1.09e-9 Superior frontal gyrus grey matter volume; CESC cis rs9902453 0.765 rs9890747 chr17:28007442 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.79 10.66 0.55 2.5e-22 Coffee consumption (cups per day); CESC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.57 -7.99 -0.44 4.19e-14 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21721210 chr19:39574878 PAPL -0.41 -6.02 -0.35 5.71e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.51 0.32 8.53e-8 Personality dimensions; CESC trans rs7088591 0.867 rs16911397 chr10:59727630 T/C cg10559231 chr5:14188039 TRIO 0.76 6.28 0.36 1.38e-9 Blood pressure; CESC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg18876405 chr7:65276391 NA 0.52 6.91 0.39 3.66e-11 Aortic root size; CESC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg21963583 chr11:68658836 MRPL21 0.42 6.05 0.35 4.92e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs901683 1.000 rs71496609 chr10:46021031 C/A cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17219981 chr11:64490808 NRXN2 0.5 6.03 0.35 5.58e-9 Gut microbiome composition (summer); CESC cis rs8062405 0.755 rs7193402 chr16:28586127 A/G cg07382826 chr16:28625726 SULT1A1 0.4 6.63 0.38 1.91e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg24562669 chr7:97807699 LMTK2 0.48 6.92 0.39 3.3e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs208520 1.000 rs12191403 chr6:66978137 C/T cg07460842 chr6:66804631 NA 0.88 10.14 0.53 1.22e-20 Exhaled nitric oxide output; CESC cis rs710216 0.917 rs710223 chr1:43411038 C/G cg03128534 chr1:43423976 SLC2A1 0.56 6.35 0.36 9.41e-10 Red cell distribution width; CESC cis rs6502050 1.000 rs6502050 chr17:80058236 C/G cg11859384 chr17:80120422 CCDC57 0.44 6.14 0.35 3.04e-9 Life satisfaction; CESC trans rs9467711 0.659 rs34605993 chr6:26454363 C/T cg01620082 chr3:125678407 NA -0.8 -6.16 -0.35 2.74e-9 Autism spectrum disorder or schizophrenia; CESC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs476633 0.691 rs11858115 chr15:41542591 G/A cg18705301 chr15:41695430 NDUFAF1 -0.48 -7.0 -0.39 2.13e-11 Glomerular filtration rate (creatinine); CESC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg18876405 chr7:65276391 NA -0.48 -6.47 -0.37 4.62e-10 Aortic root size; CESC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg00149659 chr3:10157352 C3orf10 0.75 9.21 0.49 1.05e-17 Alzheimer's disease; CESC cis rs5769765 0.908 rs138889 chr22:50226673 T/C cg02269571 chr22:50332266 NA -0.46 -5.9 -0.34 1.09e-8 Schizophrenia; CESC trans rs1814175 0.615 rs10839378 chr11:49806943 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -17.13 -0.72 8.69e-45 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12091641 chr8:145180933 NA -0.52 -6.05 -0.35 4.83e-9 Gut microbiome composition (summer); CESC cis rs929354 0.772 rs3802120 chr7:156977794 C/T cg05182265 chr7:156933206 UBE3C -0.51 -7.51 -0.42 9.08e-13 Body mass index; CESC cis rs6580649 0.882 rs59766465 chr12:48470169 G/A cg24011408 chr12:48396354 COL2A1 -0.4 -5.04 -0.3 8.67e-7 Lung cancer; CESC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg18876405 chr7:65276391 NA -0.5 -6.78 -0.38 7.91e-11 Aortic root size; CESC cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7647973 0.600 rs35174559 chr3:49287759 T/C cg06212747 chr3:49208901 KLHDC8B 0.7 10.59 0.55 4.26e-22 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23981150 chr1:161111090 NA -0.68 -8.26 -0.45 7.24e-15 Gut microbiome composition (summer); CESC trans rs7674118 0.834 rs28826088 chr4:166845815 G/A cg23810282 chr5:43037519 NA 0.67 6.02 0.35 5.77e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs9513593 0.901 rs11069350 chr13:99780461 A/G cg21788972 chr13:99853209 UBAC2 0.45 5.14 0.3 5.33e-7 Psoriasis; CESC cis rs1558375 0.679 rs31670 chr7:87059164 C/T cg00919237 chr7:87102261 ABCB4 0.38 5.17 0.3 4.56e-7 Gallbladder cancer; CESC cis rs1847505 0.609 rs9317154 chr13:61560533 A/G cg25164009 chr13:61490935 NA -0.41 -5.48 -0.32 9.91e-8 Polychlorinated biphenyl levels; CESC cis rs9581857 0.685 rs9579084 chr13:28028201 A/G cg22138327 chr13:27999177 GTF3A -0.6 -5.4 -0.31 1.47e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs2708240 1.000 rs2708271 chr7:147574111 C/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.78 -0.33 2.06e-8 QT interval (drug interaction); CESC cis rs7429990 0.965 rs34750113 chr3:47986392 C/T cg11946769 chr3:48343235 NME6 0.46 5.61 0.33 5.14e-8 Educational attainment (years of education); CESC cis rs60154123 0.772 rs614167 chr1:210425895 T/C cg25204440 chr1:209979598 IRF6 0.49 5.09 0.3 6.73e-7 Coronary artery disease; CESC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg07507251 chr3:52567010 NT5DC2 0.32 5.62 0.33 4.94e-8 Bipolar disorder; CESC cis rs62064224 0.703 rs62065492 chr17:30822607 C/T cg25809561 chr17:30822961 MYO1D 0.64 9.31 0.5 5.19e-18 Schizophrenia; CESC cis rs10463316 0.817 rs10040628 chr5:150821027 T/G cg03212797 chr5:150827313 SLC36A1 -0.49 -6.33 -0.36 1.02e-9 Metabolite levels (Pyroglutamine); CESC cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg14416269 chr4:6271139 WFS1 0.47 7.95 0.44 5.49e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2857078 0.732 rs9893756 chr17:42321109 T/C cg19774624 chr17:42201019 HDAC5 0.45 5.68 0.33 3.52e-8 Red cell distribution width;Reticulocyte count; CESC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.57 7.14 0.4 9.17e-12 Prudent dietary pattern; CESC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg05234568 chr11:5960015 NA -0.63 -8.67 -0.47 4.35e-16 DNA methylation (variation); CESC cis rs10416265 0.527 rs6510337 chr19:33545701 C/T cg27124370 chr19:33622961 WDR88 0.54 7.5 0.42 9.5e-13 Bone properties (heel); CESC cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg25427524 chr10:38739819 LOC399744 -0.71 -10.4 -0.54 1.84e-21 Extrinsic epigenetic age acceleration; CESC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg05564831 chr3:52568323 NT5DC2 0.46 7.19 0.4 6.64e-12 Electroencephalogram traits; CESC cis rs1580019 0.563 rs13225132 chr7:32800975 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.42 5.07 0.3 7.35e-7 Cognitive ability; CESC cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 6.05 0.35 4.82e-9 Breast cancer; CESC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg17294928 chr15:75287854 SCAMP5 0.53 7.12 0.4 9.86e-12 Breast cancer; CESC cis rs9611519 0.579 rs8136274 chr22:41415311 T/C cg03806693 chr22:41940476 POLR3H -0.52 -6.06 -0.35 4.68e-9 Neuroticism; CESC cis rs9611565 0.592 rs9611612 chr22:41961189 T/C cg17376030 chr22:41985996 PMM1 0.52 5.79 0.34 1.95e-8 Vitiligo; CESC cis rs644799 0.710 rs10831427 chr11:95508383 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.75 11.2 0.57 4.24e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs447 1.000 rs2158566 chr7:83755276 A/C cg22846510 chr7:83753280 SEMA3A -0.44 -5.38 -0.31 1.64e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs8114671 0.836 rs2425012 chr20:33581955 G/A cg24642439 chr20:33292090 TP53INP2 -0.46 -5.54 -0.32 7.12e-8 Height; CESC cis rs3740713 1.000 rs73440625 chr11:18470800 A/G cg23797887 chr11:18477753 LDHAL6A -0.54 -5.21 -0.31 3.72e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs11674184 0.659 rs59129126 chr2:11728388 T/C cg07314298 chr2:11723111 GREB1 -0.63 -9.51 -0.5 1.26e-18 Endometriosis; CESC cis rs2243480 1.000 rs13237037 chr7:65997882 T/C cg12463550 chr7:65579703 CRCP 0.72 5.55 0.32 6.96e-8 Diabetic kidney disease; CESC cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.58 0.47 8.19e-16 Hip circumference adjusted for BMI; CESC cis rs7147624 1.000 rs2411821 chr14:65896914 G/T cg03016385 chr14:66212404 NA -0.49 -5.23 -0.31 3.49e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6831352 0.760 rs2602859 chr4:100030583 G/A cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Alcohol dependence; CESC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg22823121 chr1:150693482 HORMAD1 0.4 5.69 0.33 3.43e-8 Melanoma; CESC cis rs4304924 0.500 rs2281856 chr13:79207644 C/T cg07926092 chr13:79233506 RNF219 -0.52 -5.87 -0.34 1.28e-8 Large artery stroke; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14971544 chr1:54955149 NA -0.65 -6.85 -0.39 5.13e-11 Gut microbiome composition (summer); CESC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg10074409 chr1:209979377 IRF6 0.35 5.73 0.33 2.68e-8 Cleft lip with or without cleft palate; CESC cis rs6831352 0.879 rs7672728 chr4:100055173 A/G cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC trans rs7582180 0.700 rs1437971 chr2:100986964 A/C cg09662051 chr2:162164883 PSMD14 0.61 6.01 0.35 5.97e-9 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08744727 chr4:206112 ZNF876P 0.51 6.51 0.37 3.74e-10 Fibrinogen levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00474465 chr10:124907942 HMX2 0.45 6.18 0.35 2.36e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.16 0.81 2.75e-62 Prudent dietary pattern; CESC cis rs1691799 0.528 rs1472314 chr12:66788838 C/G cg16791601 chr12:66731901 HELB -0.62 -9.43 -0.5 2.14e-18 White blood cell count (basophil); CESC cis rs9287719 0.967 rs6759100 chr2:10746710 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC cis rs854765 0.647 rs8066764 chr17:17974668 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 5.86 0.34 1.36e-8 Total body bone mineral density; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20087917 chr14:77924039 C14orf133;AHSA1 -0.45 -6.45 -0.37 5.36e-10 Height; CESC cis rs2415984 0.505 rs1389607 chr14:46957922 T/C cg14871534 chr14:47121158 RPL10L 0.38 5.77 0.33 2.22e-8 Number of children ever born; CESC cis rs868036 1.000 rs6494696 chr15:68103206 C/G cg08079166 chr15:68083412 MAP2K5 -0.44 -7.1 -0.4 1.15e-11 Restless legs syndrome; CESC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg27170947 chr2:26402098 FAM59B -0.87 -9.77 -0.51 1.86e-19 Gut microbiome composition (summer); CESC cis rs3126085 0.935 rs4845750 chr1:152201217 A/G cg03465714 chr1:152285911 FLG -0.45 -5.47 -0.32 1.02e-7 Atopic dermatitis; CESC trans rs9578106 0.703 rs79792825 chr13:30155776 C/T cg08144675 chr16:73097057 NA -0.58 -6.05 -0.35 4.81e-9 Breast cancer; CESC cis rs12136530 0.551 rs4244002 chr1:19738190 C/T cg01832549 chr1:19774989 CAPZB -0.36 -5.07 -0.3 7.6e-7 Lead levels in blood; CESC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg20243544 chr17:37824526 PNMT -0.47 -5.96 -0.34 7.99e-9 Glomerular filtration rate (creatinine); CESC cis rs16917546 1.000 rs7905030 chr10:64421600 G/C cg03961010 chr10:64397487 ZNF365 -0.38 -6.22 -0.36 1.94e-9 Basal cell carcinoma; CESC cis rs921968 0.613 rs2303566 chr2:219557738 C/T cg02176678 chr2:219576539 TTLL4 -0.43 -7.65 -0.43 3.72e-13 Mean corpuscular hemoglobin concentration; CESC trans rs11098499 0.644 rs28787668 chr4:120554687 G/A cg25214090 chr10:38739885 LOC399744 0.62 8.65 0.47 4.98e-16 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07084973 chr3:49209008 KLHDC8B 0.55 6.22 0.36 1.95e-9 Gut microbiome composition (summer); CESC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg23161317 chr6:28129485 ZNF389 0.49 6.19 0.36 2.28e-9 Parkinson's disease; CESC cis rs854765 0.562 rs2955381 chr17:17945500 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.33 -0.36 1.03e-9 Total body bone mineral density; CESC cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg25019033 chr10:957182 NA -0.62 -6.03 -0.35 5.46e-9 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.570 rs1869351 chr4:99077286 T/C cg24818145 chr4:99064322 C4orf37 0.4 5.25 0.31 3.18e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01133655 chr6:3140601 BPHL -0.58 -6.9 -0.39 3.77e-11 Gut microbiome composition (summer); CESC cis rs765787 0.530 rs28733848 chr15:45516047 C/T cg24006582 chr15:45444508 DUOX1 -0.58 -7.12 -0.4 1.04e-11 Uric acid levels; CESC cis rs6558174 0.863 rs17746902 chr8:22491980 A/C cg03733263 chr8:22462867 KIAA1967 -0.46 -6.06 -0.35 4.55e-9 Breast cancer; CESC cis rs8180040 0.966 rs59586735 chr3:47518325 C/T cg27129171 chr3:47204927 SETD2 -0.63 -9.49 -0.5 1.44e-18 Colorectal cancer; CESC cis rs546131 0.928 rs553789 chr11:34827579 G/A cg06937548 chr11:34938143 PDHX;APIP 0.52 6.51 0.37 3.75e-10 Lung disease severity in cystic fibrosis; CESC cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg03467027 chr4:99064603 C4orf37 0.45 5.69 0.33 3.44e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg24308560 chr3:49941425 MST1R -0.56 -7.8 -0.43 1.42e-13 Body mass index; CESC cis rs2625529 0.652 rs2957740 chr15:72307691 A/G cg16672083 chr15:72433130 SENP8 0.42 6.43 0.37 5.9e-10 Red blood cell count; CESC cis rs2075371 0.829 rs1993058 chr7:133930361 G/A cg20476274 chr7:133979776 SLC35B4 0.61 8.83 0.48 1.46e-16 Mean platelet volume; CESC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg17376030 chr22:41985996 PMM1 0.67 7.26 0.41 4.21e-12 Vitiligo; CESC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg23161317 chr6:28129485 ZNF389 0.5 6.4 0.37 7.04e-10 Depression; CESC cis rs1801251 1.000 rs283476 chr2:233650168 A/G cg08000102 chr2:233561755 GIGYF2 0.66 9.28 0.5 6.14e-18 Coronary artery disease; CESC cis rs9291683 0.610 rs993173 chr4:10323935 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -8.3 -0.45 5.41e-15 Bone mineral density; CESC cis rs1316952 0.831 rs78985577 chr12:124393117 G/A cg12597309 chr12:124393772 DNAH10 0.33 5.55 0.32 6.95e-8 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs9911578 1.000 rs2333332 chr17:56631054 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -5.28 -0.31 2.67e-7 Intelligence (multi-trait analysis); CESC cis rs4523957 0.715 rs6503321 chr17:2096580 G/A cg16513277 chr17:2031491 SMG6 -0.58 -7.87 -0.44 9.09e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11997175 0.583 rs7009719 chr8:33834824 C/G ch.8.33884649F chr8:33765107 NA 0.48 6.07 0.35 4.49e-9 Body mass index; CESC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg10494973 chr17:80897199 TBCD 0.5 5.79 0.33 2.01e-8 Breast cancer; CESC cis rs7772486 0.790 rs3924499 chr6:146232978 A/T cg23711669 chr6:146136114 FBXO30 -0.94 -13.56 -0.64 3.62e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg06453172 chr10:134556979 INPP5A -0.43 -5.7 -0.33 3.26e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1215050 0.904 rs1727285 chr4:98978821 G/A cg05340658 chr4:99064831 C4orf37 -0.54 -6.76 -0.38 8.67e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg18876405 chr7:65276391 NA -0.5 -6.92 -0.39 3.36e-11 Aortic root size; CESC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg24562669 chr7:97807699 LMTK2 0.48 7.04 0.4 1.62e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs2116941 1.000 rs2033493 chr19:10340854 A/C cg01850179 chr19:10340795 S1PR2 -0.58 -7.47 -0.42 1.15e-12 Pulse pressure; CESC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg06494592 chr3:125709126 NA -0.51 -5.46 -0.32 1.12e-7 Blood pressure (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10757852 chr3:141319363 RASA2 -0.73 -8.59 -0.47 7.57e-16 Gut microbiome composition (summer); CESC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg05754148 chr16:3507555 NAT15 0.64 7.2 0.4 6.33e-12 Tuberculosis; CESC cis rs228437 0.770 rs376192 chr6:134904524 A/G cg24504307 chr6:134963096 NA -0.41 -5.08 -0.3 7.17e-7 Melanoma; CESC cis rs6088580 0.601 rs6059872 chr20:33082775 C/A cg06115741 chr20:33292138 TP53INP2 0.46 5.91 0.34 1.02e-8 Glomerular filtration rate (creatinine); CESC cis rs861020 0.563 rs61820640 chr1:210041297 G/T cg05527609 chr1:210001259 C1orf107 -0.95 -10.65 -0.55 2.9e-22 Orofacial clefts; CESC cis rs28489187 0.706 rs233071 chr1:85806005 C/T cg16011679 chr1:85725395 C1orf52 0.47 5.48 0.32 1.01e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg07701084 chr6:150067640 NUP43 0.49 6.88 0.39 4.34e-11 Lung cancer; CESC cis rs1005277 0.522 rs9418276 chr10:37940116 G/T cg25427524 chr10:38739819 LOC399744 -0.63 -9.11 -0.49 2.03e-17 Extrinsic epigenetic age acceleration; CESC cis rs8017423 0.967 rs61996919 chr14:90701803 A/C cg14092571 chr14:90743983 NA -0.57 -8.37 -0.46 3.28e-15 Mortality in heart failure; CESC trans rs9929218 0.954 rs17715762 chr16:68828250 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.05 -0.44 2.78e-14 Colorectal cancer; CESC cis rs533581 0.816 rs8058234 chr16:88975447 C/G cg16701003 chr16:89028210 CBFA2T3 0.55 8.36 0.46 3.6e-15 Social autistic-like traits; CESC trans rs11250098 0.503 rs13270870 chr8:10770782 A/G cg15556689 chr8:8085844 FLJ10661 -0.56 -6.78 -0.38 7.86e-11 Morning vs. evening chronotype; CESC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Tonsillectomy; CESC cis rs425277 0.585 rs3107143 chr1:2045372 G/C cg04315214 chr1:2043799 PRKCZ 0.62 11.23 0.57 3.43e-24 Height; CESC cis rs12476592 0.571 rs7584404 chr2:63794342 C/T cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs75477785 1.000 rs17015217 chr1:209966629 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.86 5.67 0.33 3.78e-8 Cleft lip with or without cleft palate; CESC cis rs4423214 0.592 rs10898193 chr11:71197083 A/G cg05163923 chr11:71159392 DHCR7 0.51 5.39 0.31 1.57e-7 Vitamin D levels; CESC cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg02297831 chr4:17616191 MED28 0.52 6.01 0.35 6.19e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4237845 0.537 rs2002275 chr12:58283385 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.49 5.81 0.34 1.77e-8 Intelligence (multi-trait analysis); CESC cis rs478304 0.903 rs546202 chr11:65510024 C/T cg08755490 chr11:65554678 OVOL1 -0.45 -5.81 -0.34 1.81e-8 Acne (severe); CESC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg27266027 chr21:40555129 PSMG1 0.46 5.36 0.31 1.77e-7 Cognitive function; CESC trans rs4942242 0.763 rs7327129 chr13:44233014 T/C cg19169023 chr15:41853346 TYRO3 -0.61 -8.56 -0.47 9.12e-16 Response to tocilizumab in rheumatoid arthritis; CESC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg22968622 chr17:43663579 NA 1.35 18.5 0.75 1.23e-49 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10791097 0.694 rs3190331 chr11:130748131 C/T cg12179176 chr11:130786555 SNX19 -0.67 -10.54 -0.54 6.17e-22 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7666738 0.791 rs11097610 chr4:99011795 C/G cg17366294 chr4:99064904 C4orf37 0.58 8.26 0.45 7.23e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1270639 0.778 rs1796271 chr7:157438129 T/G cg13357408 chr7:157437802 PTPRN2 0.59 6.85 0.39 5.2e-11 Colorectal cancer; CESC cis rs5753618 0.561 rs2413047 chr22:31666026 A/G cg00478049 chr22:31556069 RNF185 0.45 5.16 0.3 4.89e-7 Colorectal cancer; CESC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg08736216 chr1:53307985 ZYG11A -0.41 -6.6 -0.38 2.22e-10 Monocyte count; CESC cis rs7937682 0.889 rs564086 chr11:111501079 C/G cg09085632 chr11:111637200 PPP2R1B -1.0 -16.2 -0.71 1.64e-41 Primary sclerosing cholangitis; CESC cis rs644799 1.000 rs627568 chr11:95569253 A/C cg03916912 chr11:95522834 CEP57;FAM76B 0.94 13.69 0.64 1.29e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.5 -0.32 9.01e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3820068 0.705 rs72645804 chr1:15868387 A/C cg17385448 chr1:15911702 AGMAT 0.38 5.9 0.34 1.1e-8 Systolic blood pressure; CESC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg00166722 chr3:10149974 C3orf24 0.48 5.98 0.34 7.15e-9 Alzheimer's disease; CESC cis rs7100689 0.646 rs10788586 chr10:82117435 A/G cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs1348850 0.526 rs2218575 chr2:178368997 C/A cg22681709 chr2:178499509 PDE11A -0.5 -5.26 -0.31 2.97e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2204008 0.665 rs11179830 chr12:38220966 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.49 0.5 1.38e-18 Bladder cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01494614 chr11:10562837 RNF141 -0.48 -6.55 -0.37 2.89e-10 Ulcerative colitis; CESC cis rs7078219 0.965 rs11190141 chr10:101292390 C/T cg09788492 chr10:101292477 NKX2-3 0.3 5.41 0.32 1.44e-7 Dental caries; CESC cis rs9902453 0.933 rs60694493 chr17:28473256 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 8.01 0.44 3.58e-14 Coffee consumption (cups per day); CESC cis rs7274811 0.681 rs291705 chr20:31969658 A/G cg21523528 chr20:32077966 CBFA2T2 0.44 5.31 0.31 2.36e-7 Height; CESC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.94 -0.34 8.84e-9 Menopause (age at onset); CESC cis rs1153858 1.000 rs7494956 chr15:45668565 T/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs9322193 0.962 rs4870048 chr6:150155460 A/G cg04369109 chr6:150039330 LATS1 -0.44 -6.02 -0.35 5.81e-9 Lung cancer; CESC trans rs966321 0.846 rs11586171 chr1:4328580 G/A cg01726854 chr17:56429881 SUPT4H1 0.44 6.12 0.35 3.33e-9 Factor VII; CESC cis rs2273669 0.667 rs12215614 chr6:109313629 T/C cg05315195 chr6:109294784 ARMC2 -0.66 -6.37 -0.36 8.17e-10 Prostate cancer; CESC cis rs2236918 0.710 rs2526700 chr1:242019999 C/A cg17736920 chr1:242011382 EXO1 0.56 6.96 0.39 2.64e-11 Menopause (age at onset); CESC cis rs1005224 0.889 rs12717566 chr14:76147507 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.43 -5.84 -0.34 1.51e-8 Large artery stroke; CESC cis rs709400 0.628 rs7150317 chr14:103921691 C/G cg12935359 chr14:103987150 CKB -0.51 -7.46 -0.42 1.24e-12 Body mass index; CESC cis rs4654899 0.802 rs61781104 chr1:21257235 T/A cg05370193 chr1:21551575 ECE1 0.41 5.68 0.33 3.61e-8 Superior frontal gyrus grey matter volume; CESC cis rs4727027 0.870 rs11525060 chr7:148801091 G/A cg23158103 chr7:148848205 ZNF398 -0.4 -6.38 -0.36 7.9e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3793683 0.520 rs12769959 chr10:134579026 A/C cg27297192 chr10:134578999 INPP5A 0.39 5.22 0.31 3.62e-7 Migraine; CESC cis rs9811920 0.638 rs10936008 chr3:99686665 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.56 6.98 0.39 2.42e-11 Axial length; CESC cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg15017067 chr4:17643749 FAM184B 0.39 5.47 0.32 1.02e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg26338869 chr17:61819248 STRADA -0.62 -8.17 -0.45 1.31e-14 Prudent dietary pattern; CESC cis rs4909189 1.000 rs62493650 chr7:158135570 G/T cg25566285 chr7:158114605 PTPRN2 0.44 5.97 0.34 7.51e-9 Response to amphetamines; CESC cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.73 10.21 0.53 7.48e-21 Monocyte percentage of white cells; CESC cis rs72945132 0.769 rs11235754 chr11:70136092 C/T cg14191688 chr11:70257035 CTTN 0.41 5.27 0.31 2.9e-7 Coronary artery disease; CESC cis rs1801251 1.000 rs13003675 chr2:233584109 C/T cg25237894 chr2:233734115 C2orf82 0.5 8.41 0.46 2.63e-15 Coronary artery disease; CESC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.82 12.48 0.61 1.92e-28 Prudent dietary pattern; CESC cis rs2120019 0.935 rs12591119 chr15:75355944 A/G cg17294928 chr15:75287854 SCAMP5 -0.65 -6.96 -0.39 2.66e-11 Blood trace element (Zn levels); CESC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg18337363 chr3:52569053 NT5DC2 0.28 5.24 0.31 3.22e-7 Bipolar disorder; CESC cis rs9916302 0.706 rs801418 chr17:37457982 G/C cg07936489 chr17:37558343 FBXL20 0.92 10.37 0.54 2.23e-21 Glomerular filtration rate (creatinine); CESC cis rs2228479 0.867 rs34272502 chr16:89949000 G/C cg06558623 chr16:89946397 TCF25 1.06 8.98 0.48 5.17e-17 Skin colour saturation; CESC trans rs931812 0.757 rs13251801 chr8:101902629 A/T cg20993868 chr7:22813445 NA 0.43 6.85 0.39 5.12e-11 Attention deficit hyperactivity disorder and conduct disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24334838 chr7:72298981 SBDSP;TYW1B 0.57 6.1 0.35 3.8e-9 Gut microbiome composition (summer); CESC cis rs7078219 0.505 rs10883372 chr10:101292483 T/A cg09788492 chr10:101292477 NKX2-3 0.34 6.41 0.37 6.45e-10 Dental caries; CESC cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -6.82 -0.39 6.12e-11 Total body bone mineral density; CESC cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg09658497 chr7:2847517 GNA12 -0.36 -5.42 -0.32 1.34e-7 Height; CESC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg14393609 chr7:65229607 NA -0.45 -6.13 -0.35 3.17e-9 Aortic root size; CESC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.73 9.93 0.52 5.69e-20 Alzheimer's disease; CESC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg27170947 chr2:26402098 FAM59B -0.82 -9.69 -0.51 3.38e-19 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs9487051 0.714 rs6902892 chr6:109627601 G/T cg01475377 chr6:109611718 NA -0.43 -6.73 -0.38 1.03e-10 Reticulocyte fraction of red cells; CESC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg12963246 chr6:28129442 ZNF389 0.54 6.97 0.39 2.47e-11 Parkinson's disease; CESC cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg04450456 chr4:17643702 FAM184B 0.36 5.06 0.3 7.87e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06767762 chr16:70323488 AARS 0.43 6.31 0.36 1.14e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2742234 0.541 rs10793427 chr10:43747443 G/A cg15436174 chr10:43711423 RASGEF1A 0.44 5.11 0.3 6.06e-7 Hirschsprung disease; CESC cis rs74181299 0.684 rs11126029 chr2:65338264 C/T cg05010058 chr2:65284262 CEP68 -0.31 -5.08 -0.3 7.18e-7 Pulse pressure; CESC cis rs6665290 0.935 rs17528667 chr1:227201770 C/T cg10327440 chr1:227177885 CDC42BPA -1.2 -31.15 -0.89 1.43e-90 Myeloid white cell count; CESC cis rs763014 0.931 rs7199839 chr16:636126 T/C cg09263875 chr16:632152 PIGQ 0.68 11.61 0.58 1.81e-25 Height; CESC cis rs4862307 0.836 rs4507404 chr4:185003767 C/T cg06737308 chr4:185021514 ENPP6 -0.45 -5.98 -0.34 7.16e-9 Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 7.19 0.4 6.49e-12 Personality dimensions; CESC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg12963246 chr6:28129442 ZNF389 0.43 6.38 0.36 8.03e-10 Cardiac Troponin-T levels; CESC cis rs11997175 0.624 rs17700425 chr8:33691467 T/G ch.8.33884649F chr8:33765107 NA 0.57 7.37 0.41 2.18e-12 Body mass index; CESC trans rs801193 1.000 rs6975195 chr7:66124774 T/A cg26939375 chr7:64535504 NA -0.64 -8.57 -0.47 8.53e-16 Aortic root size; CESC cis rs4699052 0.625 rs1850321 chr4:104252765 T/C cg16532752 chr4:104119610 CENPE -0.39 -5.47 -0.32 1.02e-7 Testicular germ cell tumor; CESC cis rs6032067 0.777 rs13038275 chr20:43780988 A/T cg10761708 chr20:43804764 PI3 0.54 6.29 0.36 1.31e-9 Blood protein levels; CESC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg07701084 chr6:150067640 NUP43 0.46 5.97 0.34 7.61e-9 Lung cancer; CESC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg00310523 chr12:86230176 RASSF9 0.42 6.35 0.36 9.52e-10 Major depressive disorder; CESC cis rs12220238 1.000 rs115418388 chr10:75976296 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.44 0.32 1.24e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2228479 0.850 rs62054640 chr16:89823157 C/T cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs9611565 0.840 rs2234052 chr22:41777241 A/G cg17376030 chr22:41985996 PMM1 0.6 6.45 0.37 5.42e-10 Vitiligo; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23538226 chr2:25016181 CENPO;C2orf79 -0.43 -6.1 -0.35 3.67e-9 Gambling; CESC cis rs7666738 0.791 rs1426674 chr4:98924247 C/A cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg05340658 chr4:99064831 C4orf37 0.84 12.83 0.62 1.29e-29 Colonoscopy-negative controls vs population controls; CESC cis rs8058578 1.000 rs7204278 chr16:30730274 A/G cg02466173 chr16:30829666 NA -0.42 -6.79 -0.38 7.37e-11 Multiple myeloma; CESC cis rs7116495 0.881 rs676721 chr11:71770638 G/A cg10381502 chr11:71823885 C11orf51 -0.64 -5.3 -0.31 2.5e-7 Severe influenza A (H1N1) infection; CESC cis rs634534 0.561 rs655744 chr11:65776585 G/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.7 -9.99 -0.52 3.64e-20 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs1878931 0.545 rs28603 chr16:3449479 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.73 -8.22 -0.45 9.14e-15 Body mass index (adult); CESC cis rs3733585 0.631 rs4697707 chr4:10119787 G/T cg05927159 chr4:10118984 WDR1 0.34 5.08 0.3 7.04e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg08859206 chr1:53392774 SCP2 0.54 7.12 0.4 1.03e-11 Monocyte count; CESC trans rs11039798 1.000 rs7123704 chr11:48580535 G/A cg15704280 chr7:45808275 SEPT13 0.7 6.57 0.37 2.68e-10 Axial length; CESC cis rs4474465 0.790 rs6592790 chr11:78262618 T/C cg27205649 chr11:78285834 NARS2 0.42 5.23 0.31 3.39e-7 Alzheimer's disease (survival time); CESC cis rs12711979 0.509 rs10195488 chr2:3824135 T/C cg17052675 chr2:3827356 NA -0.66 -11.02 -0.56 1.71e-23 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg26314531 chr2:26401878 FAM59B -0.83 -9.28 -0.5 6.08e-18 Gut microbiome composition (summer); CESC cis rs9399135 0.967 rs12527683 chr6:135324534 C/T cg22676075 chr6:135203613 NA 0.52 7.31 0.41 3.25e-12 Red blood cell count; CESC cis rs1801251 1.000 rs11676216 chr2:233706368 C/T cg25237894 chr2:233734115 C2orf82 -0.46 -8.05 -0.44 2.73e-14 Coronary artery disease; CESC cis rs7130144 0.541 rs7936386 chr11:130462505 T/C cg26307797 chr11:130446613 NA -0.76 -6.78 -0.38 7.92e-11 Urate levels in lean individuals; CESC cis rs56235845 0.694 rs6875461 chr5:176754665 C/T cg16006841 chr5:176797999 RGS14 -0.48 -6.08 -0.35 4.07e-9 Hemoglobin concentration;Hematocrit; CESC cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.51 0.46 1.33e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.41 0.41 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2882667 1.000 rs10064130 chr5:138309307 C/T cg04439458 chr5:138467593 SIL1 -0.37 -5.85 -0.34 1.44e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg24450063 chr1:156163899 SLC25A44 1.1 23.34 0.82 3.27e-66 Testicular germ cell tumor; CESC cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg25554036 chr4:6271136 WFS1 0.51 8.36 0.46 3.55e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs977987 0.778 rs12445726 chr16:75465575 C/T cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17176517 chr3:125239027 SNX4 -0.42 -6.53 -0.37 3.27e-10 Gambling; CESC cis rs2952156 0.920 rs1018246 chr17:37835240 C/T cg00129232 chr17:37814104 STARD3 -0.74 -10.75 -0.55 1.35e-22 Asthma; CESC cis rs2243480 1.000 rs13247184 chr7:65358928 A/G cg12463550 chr7:65579703 CRCP 0.69 5.53 0.32 7.85e-8 Diabetic kidney disease; CESC cis rs3096299 0.582 rs12935119 chr16:89542874 A/T cg08392591 chr16:89556376 ANKRD11 0.52 7.06 0.4 1.44e-11 Multiple myeloma (IgH translocation); CESC cis rs6580649 0.657 rs57863747 chr12:48470425 G/T cg05342945 chr12:48394962 COL2A1 0.5 5.74 0.33 2.59e-8 Lung cancer; CESC cis rs11098499 0.954 rs10006525 chr4:120408931 T/G cg24375607 chr4:120327624 NA 0.46 5.79 0.34 1.96e-8 Corneal astigmatism; CESC cis rs116095464 0.558 rs28636067 chr5:199415 G/A cg22496380 chr5:211416 CCDC127 -0.94 -9.83 -0.52 1.25e-19 Breast cancer; CESC cis rs4950322 0.570 rs72692920 chr1:146780214 C/T cg16700924 chr1:146552102 NA -0.41 -5.1 -0.3 6.37e-7 Protein quantitative trait loci; CESC cis rs11252926 0.537 rs4881255 chr10:453638 T/C cg18196295 chr10:418757 DIP2C 0.54 7.37 0.41 2.17e-12 Psychosis in Alzheimer's disease; CESC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg08736216 chr1:53307985 ZYG11A -0.42 -7.01 -0.4 1.93e-11 Monocyte count; CESC cis rs763121 0.853 rs5750677 chr22:39147715 C/T cg14440974 chr22:39074834 NA -0.38 -5.25 -0.31 3.06e-7 Menopause (age at onset); CESC cis rs11722228 0.522 rs73212880 chr4:10115692 T/A cg14348967 chr4:10160060 NA -0.4 -5.03 -0.3 9.07e-7 Gout;Urate levels;Serum uric acid levels; CESC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg23985595 chr17:80112537 CCDC57 0.42 6.52 0.37 3.56e-10 Life satisfaction; CESC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg22433210 chr17:43662623 NA 0.99 11.0 0.56 1.96e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2730245 0.527 rs842702 chr7:158696814 C/T cg24397884 chr7:158709396 WDR60 0.85 8.84 0.48 1.41e-16 Height; CESC cis rs35110281 0.807 rs4818850 chr21:45028071 T/G cg04455712 chr21:45112962 RRP1B 0.42 6.34 0.36 9.76e-10 Mean corpuscular volume; CESC cis rs9611519 0.780 rs9611542 chr22:41677317 C/T cg17376030 chr22:41985996 PMM1 0.51 5.72 0.33 2.91e-8 Neuroticism; CESC cis rs12711979 0.740 rs6711964 chr2:3820916 A/T cg17052675 chr2:3827356 NA -0.41 -6.47 -0.37 4.74e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg10691866 chr7:65817282 TPST1 0.35 5.77 0.33 2.23e-8 Aortic root size; CESC cis rs6540559 0.546 rs735693 chr1:210033988 A/C cg22029157 chr1:209979665 IRF6 0.66 7.25 0.41 4.53e-12 Cleft lip with or without cleft palate; CESC cis rs10411936 0.608 rs7259642 chr19:16601926 C/A cg10248733 chr19:16607483 C19orf44;CALR3 0.52 6.28 0.36 1.35e-9 White blood cell count;Multiple sclerosis; CESC cis rs34779708 0.801 rs12098720 chr10:35538683 G/A cg03585969 chr10:35415529 CREM 0.57 6.57 0.37 2.6200000000000003e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs2073300 0.609 rs6137939 chr20:23390206 C/T cg16736954 chr20:23401023 NAPB -0.76 -6.13 -0.35 3.22e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9486719 1.000 rs3798289 chr6:97023632 T/C cg18709589 chr6:96969512 KIAA0776 -0.52 -5.7 -0.33 3.16e-8 Migraine;Coronary artery disease; CESC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg07636037 chr3:49044803 WDR6 0.66 9.82 0.52 1.28e-19 Parkinson's disease; CESC cis rs2652834 0.808 rs4775614 chr15:63351687 A/G cg05507819 chr15:63340323 TPM1 0.62 6.08 0.35 4.22e-9 HDL cholesterol; CESC cis rs4253772 0.592 rs1807600 chr22:46644640 A/G cg24881330 chr22:46731750 TRMU 0.73 7.96 0.44 5.2e-14 LDL cholesterol;Cholesterol, total; CESC trans rs4335177 0.963 rs1907440 chr9:109373874 T/C cg12580783 chr12:49362475 WNT10B -0.34 -6.65 -0.38 1.72e-10 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 9.63 0.51 5.16e-19 Axial length; CESC cis rs12142240 0.698 rs45517837 chr1:46859225 A/G cg10495392 chr1:46806563 NSUN4 0.56 6.17 0.35 2.61e-9 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08504806 chr7:2027239 MAD1L1 0.5 6.86 0.39 4.8e-11 Fibrinogen levels; CESC cis rs35955747 0.838 rs7285171 chr22:31598367 C/T cg25791279 chr22:32026902 PISD -0.47 -5.64 -0.33 4.3e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs12136530 0.651 rs4912081 chr1:19710002 G/T cg01832549 chr1:19774989 CAPZB -0.37 -5.37 -0.31 1.7e-7 Lead levels in blood; CESC cis rs9487051 0.768 rs463503 chr6:109525757 T/C cg01475377 chr6:109611718 NA -0.46 -6.91 -0.39 3.64e-11 Reticulocyte fraction of red cells; CESC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg18876405 chr7:65276391 NA -0.57 -7.61 -0.42 4.7e-13 Aortic root size; CESC cis rs1270639 0.778 rs2530405 chr7:157446021 C/G cg13357408 chr7:157437802 PTPRN2 0.62 7.26 0.41 4.32e-12 Colorectal cancer; CESC cis rs561341 0.883 rs72821942 chr17:30234460 C/T cg13647721 chr17:30228624 UTP6 0.6 5.49 0.32 9.34e-8 Hip circumference adjusted for BMI; CESC cis rs9902453 0.845 rs2259855 chr17:28097860 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.47 -0.46 1.67e-15 Coffee consumption (cups per day); CESC cis rs1348850 0.567 rs880898 chr2:178532470 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.25 0.41 4.54e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg22143856 chr6:28129313 ZNF389 0.42 5.2 0.3 3.91e-7 Parkinson's disease; CESC cis rs910316 0.663 rs175034 chr14:75463687 T/G cg08847533 chr14:75593920 NEK9 -0.87 -14.71 -0.67 3.14e-36 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24149930 chr19:33182641 NUDT19 0.44 6.12 0.35 3.35e-9 Gut microbiota (bacterial taxa); CESC cis rs7605827 0.964 rs6748427 chr2:15564799 T/C cg19274914 chr2:15703543 NA 0.34 6.04 0.35 5.23e-9 Educational attainment (years of education); CESC cis rs668210 0.793 rs534201 chr11:65776728 A/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.65 6.89 0.39 4.14e-11 Cerebrospinal fluid biomarker levels; CESC cis rs7904368 0.806 rs7899853 chr10:16857603 A/T cg14835575 chr10:16859367 RSU1 0.51 5.25 0.31 3.19e-7 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg00033643 chr7:134001901 SLC35B4 0.43 5.67 0.33 3.78e-8 Mean platelet volume; CESC cis rs7666738 0.606 rs13108868 chr4:99083753 C/T cg05340658 chr4:99064831 C4orf37 0.65 9.03 0.49 3.66e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2315504 0.626 rs757271 chr17:39003503 A/C cg05063374 chr17:38953512 KRT28 0.37 5.07 0.3 7.43e-7 Height; CESC cis rs9300255 0.544 rs10772995 chr12:123671761 T/C cg00376283 chr12:123451042 ABCB9 0.71 8.71 0.47 3.27e-16 Neutrophil percentage of white cells; CESC cis rs4975709 0.569 rs931509 chr5:1858821 A/T cg20790798 chr5:1857306 NA -0.39 -5.07 -0.3 7.57e-7 Cardiovascular disease risk factors; CESC cis rs2243480 1.000 rs73142162 chr7:65374296 A/T cg12463550 chr7:65579703 CRCP 0.7 5.45 0.32 1.16e-7 Diabetic kidney disease; CESC cis rs9287719 0.967 rs759403 chr2:10729897 C/T cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.35e-8 Prostate cancer; CESC cis rs909674 0.818 rs8136980 chr22:39844574 G/A cg11247378 chr22:39784982 NA -0.62 -8.9 -0.48 9.06e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg07414643 chr4:187882934 NA 0.5 7.3 0.41 3.33e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs9291683 0.668 rs2241474 chr4:10086015 T/C cg26043149 chr18:55253948 FECH 0.46 6.17 0.35 2.51e-9 Bone mineral density; CESC cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 5.34 0.31 1.96e-7 Breast cancer; CESC cis rs7551222 0.752 rs12133735 chr1:204556836 G/T cg20240347 chr1:204465584 NA -0.3 -6.02 -0.35 5.94e-9 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17504096 chr1:205649242 SLC45A3 0.54 6.4 0.37 7.01e-10 Gut microbiome composition (summer); CESC cis rs2599510 0.693 rs2754514 chr2:32788836 T/A cg02381751 chr2:32503542 YIPF4 0.58 7.59 0.42 5.37e-13 Interleukin-18 levels; CESC cis rs12893668 0.663 rs12889731 chr14:104087482 C/T cg19000871 chr14:103996768 TRMT61A -0.34 -5.07 -0.3 7.37e-7 Reticulocyte count; CESC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg13206674 chr6:150067644 NUP43 -0.43 -5.98 -0.35 7.04e-9 Lung cancer; CESC cis rs8180040 0.690 rs7640397 chr3:46989828 C/T cg27129171 chr3:47204927 SETD2 0.66 9.68 0.51 3.5e-19 Colorectal cancer; CESC cis rs8135665 0.600 rs8142379 chr22:38450971 G/A cg13116946 chr22:38479732 SLC16A8 0.43 5.26 0.31 2.96e-7 Advanced age-related macular degeneration;Age-related macular degeneration; CESC cis rs3820928 1.000 rs10197757 chr2:227763244 A/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.9 -0.34 1.12e-8 Pulmonary function; CESC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg09658497 chr7:2847517 GNA12 0.44 6.39 0.37 7.58e-10 Height; CESC cis rs868036 0.609 rs16951304 chr15:68089618 T/C cg08079166 chr15:68083412 MAP2K5 0.43 5.8 0.34 1.84e-8 Restless legs syndrome; CESC cis rs2243480 1.000 rs427044 chr7:65508545 G/A cg18252515 chr7:66147081 NA -1.28 -12.44 -0.61 2.78e-28 Diabetic kidney disease; CESC cis rs78456975 1.000 rs6730391 chr2:1566838 A/C cg26248373 chr2:1572462 NA -0.56 -5.33 -0.31 2.07e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs3096299 0.967 rs753852 chr16:89446419 G/A cg00750074 chr16:89608354 SPG7 -0.39 -5.38 -0.31 1.65e-7 Multiple myeloma (IgH translocation); CESC cis rs9790314 0.846 rs6791213 chr3:161033721 A/G cg03342759 chr3:160939853 NMD3 -0.54 -7.78 -0.43 1.65e-13 Morning vs. evening chronotype; CESC cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg27211696 chr2:191398769 TMEM194B -0.52 -7.77 -0.43 1.78e-13 Pulse pressure; CESC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg25036284 chr2:26402008 FAM59B -0.62 -6.84 -0.39 5.44e-11 Gut microbiome composition (summer); CESC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg24101359 chr6:42928495 GNMT 0.68 11.09 0.56 9.82e-24 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2991971 0.810 rs12119202 chr1:45925931 A/T cg24296786 chr1:45957014 TESK2 -0.62 -8.77 -0.47 2.21e-16 High light scatter reticulocyte count; CESC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg04282206 chr17:62833786 PLEKHM1P 0.57 6.51 0.37 3.69e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.75 0.47 2.59e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs1881797 1.000 rs12061460 chr1:247686787 G/A cg11166453 chr1:247681781 NA 0.44 5.77 0.33 2.24e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs4141404 0.673 rs1968023 chr22:31942770 A/G cg02404636 chr22:31891804 SFI1 -0.43 -5.41 -0.32 1.42e-7 Paclitaxel-induced neuropathy; CESC trans rs8012 0.537 rs11085825 chr19:13007458 A/G cg12649340 chr1:119575837 WARS2 -0.44 -6.01 -0.35 6.26e-9 Mean corpuscular hemoglobin;Mean corpuscular volume;Blood metabolite levels; CESC cis rs6964587 0.900 rs62467794 chr7:91850578 C/T cg17063962 chr7:91808500 NA 0.57 6.75 0.38 9.37e-11 Breast cancer; CESC cis rs6594499 0.500 rs10491424 chr5:110453806 T/C cg04022379 chr5:110408740 TSLP 0.42 7.33 0.41 2.8e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs11122272 0.735 rs2572248 chr1:231514942 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs2404602 0.692 rs55864032 chr15:77122548 A/G cg26408565 chr15:76604113 ETFA -0.38 -5.56 -0.32 6.49e-8 Blood metabolite levels; CESC cis rs763014 0.931 rs1981483 chr16:630665 G/A cg00908189 chr16:619842 PIGQ 0.66 9.26 0.49 7.42e-18 Height; CESC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg24829409 chr8:58192753 C8orf71 -0.67 -8.09 -0.44 2.23e-14 Developmental language disorder (linguistic errors); CESC cis rs7789940 1.000 rs17149161 chr7:75978229 C/A cg10167463 chr7:75959203 YWHAG -0.56 -7.09 -0.4 1.23e-11 Multiple sclerosis; CESC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.2 0.53 7.97e-21 Prudent dietary pattern; CESC cis rs977987 0.806 rs1109342 chr16:75445675 A/G cg03315344 chr16:75512273 CHST6 -0.38 -5.44 -0.32 1.24e-7 Dupuytren's disease; CESC cis rs2204008 0.571 rs1117803 chr12:38281007 C/G cg26384229 chr12:38710491 ALG10B -0.46 -5.95 -0.34 8.45e-9 Bladder cancer; CESC cis rs9914544 0.932 rs11870265 chr17:18820985 A/T cg26378065 chr17:18585709 ZNF286B 0.47 6.15 0.35 2.86e-9 Educational attainment (years of education); CESC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg18350739 chr11:68623251 NA -0.45 -6.91 -0.39 3.7e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1387259 0.790 rs2732445 chr12:48645533 C/T cg24011408 chr12:48396354 COL2A1 0.44 6.15 0.35 2.82e-9 Obstructive sleep apnea trait (apnea hypopnea index); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26565884 chr16:89187106 ACSF3 -0.55 -6.63 -0.38 1.84e-10 Gut microbiome composition (summer); CESC cis rs17376456 0.877 rs10052428 chr5:93476530 T/C cg21475434 chr5:93447410 FAM172A 0.86 7.66 0.43 3.53e-13 Diabetic retinopathy; CESC cis rs7223966 1.000 rs11079511 chr17:61858537 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 6.07 0.35 4.36e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1124376 0.935 rs67660889 chr3:20170538 G/C cg05072819 chr3:20081367 KAT2B 0.54 5.81 0.34 1.81e-8 Bipolar disorder and schizophrenia; CESC cis rs2072732 0.861 rs67025412 chr1:2951806 T/C cg15211996 chr1:2936768 ACTRT2 0.34 5.95 0.34 8.31e-9 Plateletcrit; CESC cis rs2243480 1.000 rs4718317 chr7:65648901 A/G cg18252515 chr7:66147081 NA 1.25 12.08 0.6 4.67e-27 Diabetic kidney disease; CESC cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg10523679 chr1:76189770 ACADM 0.68 7.95 0.44 5.33e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6963495 0.556 rs818474 chr7:105155243 A/T cg13798780 chr7:105162888 PUS7 0.51 6.2 0.36 2.18e-9 Bipolar disorder (body mass index interaction); CESC cis rs11098499 0.754 rs1849457 chr4:120254355 A/G cg09307838 chr4:120376055 NA 0.79 10.5 0.54 8.92e-22 Corneal astigmatism; CESC cis rs11696501 0.739 rs6073835 chr20:44286454 C/T cg11783356 chr20:44313418 WFDC10B -0.33 -5.16 -0.3 4.82e-7 Brain structure; CESC cis rs36051895 0.589 rs17492549 chr9:5202830 A/C cg02405213 chr9:5042618 JAK2 -0.48 -5.59 -0.32 5.61e-8 Pediatric autoimmune diseases; CESC trans rs11098499 0.739 rs7441137 chr4:120133221 G/T cg25214090 chr10:38739885 LOC399744 -0.54 -7.16 -0.4 7.81e-12 Corneal astigmatism; CESC cis rs4595586 0.525 rs1400279 chr12:39343825 T/A cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.2e-8 Morning vs. evening chronotype; CESC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs17125944 0.505 rs75194546 chr14:53212069 A/C cg00686598 chr14:53173677 PSMC6 1.42 11.93 0.59 1.52e-26 Alzheimer's disease (late onset); CESC cis rs13242816 1.000 rs35800776 chr7:116110069 C/A cg04696780 chr7:116139425 CAV2 -0.59 -5.24 -0.31 3.3e-7 P wave duration; CESC cis rs10504229 0.679 rs2218271 chr8:58052446 T/A cg24829409 chr8:58192753 C8orf71 -0.5 -6.25 -0.36 1.62e-9 Developmental language disorder (linguistic errors); CESC cis rs11690935 0.959 rs6754817 chr2:172663394 C/T cg13550731 chr2:172543902 DYNC1I2 -0.94 -13.89 -0.65 2.46e-33 Schizophrenia; CESC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.16 0.4 7.84e-12 Height; CESC cis rs1569175 1.000 rs2189471 chr2:200924202 G/A cg19045956 chr2:200819837 C2orf60;C2orf47 0.64 5.36 0.31 1.83e-7 Response to treatment for acute lymphoblastic leukemia; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21582582 chr3:182698605 DCUN1D1 -0.47 -6.33 -0.36 1.07e-9 Asthma; CESC cis rs290268 0.669 rs10993693 chr9:93557698 C/T cg02608019 chr9:93564028 SYK 0.49 7.05 0.4 1.54e-11 Platelet count; CESC cis rs3806843 1.000 rs7732179 chr5:140199039 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.35 -0.31 1.88e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg03676636 chr4:99064102 C4orf37 0.36 5.36 0.31 1.78e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11966931 1.000 rs17528993 chr6:108114633 C/G cg10566610 chr6:108093680 SCML4 0.32 5.62 0.33 4.89e-8 Neutrophil percentage of white cells; CESC cis rs3026101 0.671 rs8066702 chr17:5310121 A/C cg25236894 chr17:5323110 RPAIN;NUP88 0.45 6.06 0.35 4.6e-9 Body mass index; CESC cis rs4986811 0.929 rs5030180 chr11:32448239 G/A cg27409910 chr11:32454216 WT1 0.42 5.17 0.3 4.62e-7 Rubella-specific interleukin-6 secretion; CESC cis rs8103278 1.000 rs17571725 chr19:46290822 C/T cg14061069 chr19:46274453 DMPK -0.37 -5.16 -0.3 4.94e-7 Coronary artery disease; CESC cis rs9309711 0.961 rs11678655 chr2:3476234 T/G cg10845886 chr2:3471009 TTC15 -0.87 -12.51 -0.61 1.63e-28 Neurofibrillary tangles; CESC trans rs1814175 0.502 rs12365889 chr11:49623034 G/A cg15704280 chr7:45808275 SEPT13 -0.87 -11.16 -0.57 5.81e-24 Height; CESC cis rs68170813 0.559 rs76534758 chr7:106963262 T/C cg02696742 chr7:106810147 HBP1 -0.55 -5.17 -0.3 4.64e-7 Coronary artery disease; CESC cis rs11997175 0.631 rs7826866 chr8:33665090 A/T ch.8.33884649F chr8:33765107 NA 0.46 5.81 0.34 1.78e-8 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00289125 chr2:20251812 LAPTM4A -0.54 -6.32 -0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.686 rs1292337 chr6:145967807 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.97 -0.39 2.51e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2228479 0.614 rs1137042 chr16:89975638 A/G cg04013166 chr16:89971882 TCF25 0.71 8.54 0.46 1.1e-15 Skin colour saturation; CESC cis rs6062302 0.522 rs3761126 chr20:62252044 C/T cg06363034 chr20:62225388 GMEB2 -0.52 -6.74 -0.38 9.85e-11 Glioblastoma; CESC cis rs651907 0.514 rs34301719 chr3:101417993 C/T cg12386194 chr3:101231763 SENP7 0.48 5.87 0.34 1.3e-8 Colorectal cancer; CESC cis rs9467711 0.606 rs9393708 chr6:26362643 C/T cg12826209 chr6:26865740 GUSBL1 -0.63 -5.7 -0.33 3.24e-8 Autism spectrum disorder or schizophrenia; CESC cis rs7219021 0.774 rs9909916 chr17:46961493 C/T cg16584676 chr17:46985605 UBE2Z -0.66 -7.42 -0.41 1.61e-12 Schizophrenia or bipolar disorder; CESC cis rs3126085 0.825 rs11204933 chr1:152172185 C/T cg03465714 chr1:152285911 FLG -0.45 -5.54 -0.32 7.45e-8 Atopic dermatitis; CESC cis rs6582630 0.519 rs11495699 chr12:38286219 G/T cg13010199 chr12:38710504 ALG10B 0.53 6.39 0.37 7.43e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg11890956 chr21:40555474 PSMG1 0.68 9.49 0.5 1.4e-18 Cognitive function; CESC cis rs10089 1.000 rs1560636 chr5:127447987 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.8 11.17 0.57 5.47e-24 Ileal carcinoids; CESC cis rs7945705 0.967 rs34842234 chr11:8891894 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.5 7.94 0.44 5.61e-14 Hemoglobin concentration; CESC cis rs748404 0.660 rs690472 chr15:43764368 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.5 0.42 9.94e-13 Lung cancer; CESC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg23590916 chr17:43697445 MGC57346 -0.61 -6.51 -0.37 3.66e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs796364 0.951 rs36086821 chr2:201067436 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.61 5.74 0.33 2.56e-8 Schizophrenia; CESC cis rs1707322 0.686 rs11211179 chr1:46228082 A/C cg05343316 chr1:45956843 TESK2 0.47 6.02 0.35 5.8e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1045902 0.516 rs7851 chr2:73478461 A/T cg01422370 chr2:73384389 NA 0.36 5.07 0.3 7.65e-7 Intelligence (multi-trait analysis); CESC trans rs617791 0.678 rs551659 chr11:65749645 C/T cg17712092 chr4:129076599 LARP1B 0.74 10.3 0.53 3.76e-21 Breast cancer; CESC cis rs35110281 0.776 rs9983763 chr21:44990578 A/G cg21573476 chr21:45109991 RRP1B 0.47 6.44 0.37 5.67e-10 Mean corpuscular volume; CESC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs4144743 0.938 rs35069360 chr17:45321270 C/T cg18085866 chr17:45331354 ITGB3 -0.65 -7.07 -0.4 1.39e-11 Body mass index; CESC cis rs5758511 0.680 rs5758687 chr22:42656588 A/T cg00645731 chr22:42541494 CYP2D7P1 0.56 8.58 0.47 8.05e-16 Birth weight; CESC cis rs17125944 0.686 rs9646151 chr14:53354464 C/G cg00686598 chr14:53173677 PSMC6 -0.6 -5.54 -0.32 7.42e-8 Alzheimer's disease (late onset); CESC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg07507251 chr3:52567010 NT5DC2 0.33 5.67 0.33 3.76e-8 Electroencephalogram traits; CESC cis rs28673728 0.897 rs28391281 chr1:38408974 T/C cg26398791 chr1:38455867 SF3A3 -0.41 -5.23 -0.31 3.4e-7 Red cell distribution width; CESC cis rs2404602 0.692 rs35395069 chr15:76986334 C/T cg22467129 chr15:76604101 ETFA -0.34 -5.12 -0.3 5.9e-7 Blood metabolite levels; CESC cis rs66686620 1.000 rs6724990 chr2:69247789 C/T cg12800200 chr2:69260302 ANTXR1 0.42 6.22 0.36 1.93e-9 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09560399 chr11:19138459 ZDHHC13 -0.57 -6.63 -0.38 1.87e-10 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs160642 chr7:65558373 C/T cg12463550 chr7:65579703 CRCP 0.74 5.71 0.33 3.02e-8 Diabetic kidney disease; CESC trans rs7246760 0.737 rs57296518 chr19:9819950 A/G cg02900749 chr2:68251473 NA -0.77 -7.13 -0.4 9.35e-12 Pursuit maintenance gain; CESC cis rs710216 0.917 rs2297977 chr1:43415288 G/T cg07803811 chr1:43423981 SLC2A1 0.5 5.36 0.31 1.84e-7 Red cell distribution width; CESC cis rs7927771 1.000 rs11039412 chr11:47841581 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -6.04 -0.35 5.24e-9 Subjective well-being; CESC cis rs10883723 0.810 rs12265877 chr10:104247247 C/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.93e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs4919694 1.000 rs12268849 chr10:104737682 G/A cg04362960 chr10:104952993 NT5C2 0.68 5.88 0.34 1.22e-8 Arsenic metabolism; CESC cis rs9457247 0.663 rs2237274 chr6:167442995 C/G cg25258033 chr6:167368657 RNASET2 0.35 5.07 0.3 7.41e-7 Crohn's disease; CESC cis rs7605378 1.000 rs769958 chr2:200695901 G/A cg23649088 chr2:200775458 C2orf69 0.5 6.63 0.38 1.9e-10 Osteoporosis; CESC cis rs10861342 1.000 rs11112380 chr12:105526695 C/T cg23923672 chr12:105501055 KIAA1033 0.67 5.09 0.3 6.92e-7 IgG glycosylation; CESC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC trans rs7090925 0.853 rs2892582 chr10:8482310 C/T cg02275004 chr12:976007 WNK1;HSN2 -0.44 -6.0 -0.35 6.41e-9 Systemic lupus erythematosus; CESC cis rs9583531 0.657 rs9521915 chr13:111384528 C/T cg15841412 chr13:111365552 ING1 0.45 5.66 0.33 3.98e-8 Coronary artery disease; CESC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg05564831 chr3:52568323 NT5DC2 0.45 6.89 0.39 4.03e-11 Bipolar disorder; CESC cis rs5997397 0.967 rs5762777 chr22:29150044 T/C cg15103426 chr22:29168792 CCDC117 0.47 6.07 0.35 4.42e-9 Red cell distribution width; CESC cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.04 0.35 5.19e-9 Colorectal cancer; CESC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg04369109 chr6:150039330 LATS1 0.47 6.64 0.38 1.81e-10 Lung cancer; CESC cis rs10754283 0.967 rs7523046 chr1:90109499 G/A cg21401794 chr1:90099060 LRRC8C 0.68 9.24 0.49 8.33e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs939574 1.000 rs7574937 chr2:220099331 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.83 7.33 0.41 2.78e-12 Platelet distribution width; CESC cis rs2885056 0.830 rs2018810 chr19:10669172 A/G cg09936142 chr19:10668400 KRI1 -0.43 -5.08 -0.3 7.14e-7 Red cell distribution width; CESC cis rs4919087 1.000 rs10786329 chr10:99074621 G/A cg25902810 chr10:99078978 FRAT1 0.71 10.31 0.54 3.48e-21 Monocyte count; CESC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg24154853 chr7:158122151 PTPRN2 0.45 7.34 0.41 2.65e-12 Calcium levels; CESC cis rs6831352 0.918 rs7670241 chr4:100059619 G/T cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC trans rs60843830 1.000 rs7595075 chr2:264019 C/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.69 8.62 0.47 6.13e-16 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs854765 0.964 rs854762 chr17:18009102 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.47 -5.85 -0.34 1.48e-8 Total body bone mineral density; CESC trans rs2797160 0.904 rs2326292 chr6:125999674 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.48 -6.62 -0.38 2.02e-10 Endometrial cancer; CESC cis rs17253792 0.822 rs79024594 chr14:56092997 T/G cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs748404 0.587 rs690276 chr15:43704558 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.47 0.46 1.69e-15 Lung cancer; CESC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg21770322 chr7:97807741 LMTK2 0.57 8.63 0.47 5.93e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs8002861 0.875 rs12869697 chr13:44439169 T/C cg19180546 chr13:44453867 C13orf31;CCDC122 -0.43 -5.4 -0.31 1.47e-7 Leprosy; CESC cis rs4268898 0.636 rs72787383 chr2:24583861 G/A cg06627628 chr2:24431161 ITSN2 -1.03 -11.63 -0.58 1.53e-25 Asthma; CESC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg11644478 chr21:40555479 PSMG1 -0.8 -11.61 -0.58 1.88e-25 Cognitive function; CESC cis rs1538970 1.000 rs17395553 chr1:45864761 C/T cg05343316 chr1:45956843 TESK2 0.83 11.71 0.58 8.6e-26 Platelet count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20645649 chr9:127624485 RPL35 -0.53 -7.57 -0.42 6.31e-13 Gambling; CESC trans rs1728785 0.901 rs11075688 chr16:68655924 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.69 -7.98 -0.44 4.42e-14 Ulcerative colitis; CESC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg24675658 chr1:53192096 ZYG11B -0.56 -7.0 -0.4 2.05e-11 Monocyte count; CESC cis rs11645898 0.748 rs72791112 chr16:72204069 T/A cg14768367 chr16:72042858 DHODH -0.73 -5.84 -0.34 1.49e-8 Blood protein levels; CESC trans rs7726839 0.794 rs10474792 chr5:600058 G/A cg25482853 chr8:67687455 SGK3 0.62 6.38 0.36 8.03e-10 Obesity-related traits; CESC cis rs72945132 0.882 rs7937984 chr11:70144254 C/T cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs2522056 1.000 rs2706339 chr5:131800105 G/T cg24060327 chr5:131705240 SLC22A5 0.61 6.93 0.39 3.24e-11 Lymphocyte counts;Fibrinogen; CESC cis rs7666738 0.546 rs10018080 chr4:98758436 C/A cg17366294 chr4:99064904 C4orf37 0.49 6.1 0.35 3.68e-9 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00852613 chr13:50159829 RCBTB1 0.44 6.28 0.36 1.37e-9 Gut microbiota (bacterial taxa); CESC cis rs9486719 0.948 rs2472904 chr6:96874962 T/G cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs1797885 0.934 rs299650 chr3:12538595 T/C cg26432171 chr3:12704882 RAF1 -0.48 -6.0 -0.35 6.52e-9 Immature fraction of reticulocytes; CESC cis rs735539 1.000 rs2290143 chr13:21280363 A/G cg04906043 chr13:21280425 IL17D 0.39 5.92 0.34 1.01e-8 Dental caries; CESC trans rs2391518 0.639 rs2968997 chr4:130784669 A/C cg24601559 chr2:43328536 NA 0.35 6.1 0.35 3.83e-9 Body mass index; CESC cis rs2115536 0.730 rs12898642 chr15:80182050 T/C cg00225070 chr15:80189496 MTHFS 0.48 6.66 0.38 1.54e-10 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs892961 0.932 rs66886702 chr17:75412714 G/A cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg21724239 chr8:58056113 NA 0.57 6.1 0.35 3.8e-9 Developmental language disorder (linguistic errors); CESC cis rs67478160 0.643 rs3818085 chr14:104215985 C/T cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.06 -0.4 1.45e-11 Schizophrenia; CESC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg22029157 chr1:209979665 IRF6 0.7 10.01 0.52 3.13e-20 Cleft lip with or without cleft palate; CESC cis rs7216064 1.000 rs2365764 chr17:65857714 G/A cg07042672 chr17:66097459 LOC651250 -0.54 -5.62 -0.33 4.77e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 5.03 0.3 8.93e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg24562669 chr7:97807699 LMTK2 0.51 7.54 0.42 7.55e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg11965913 chr1:205819406 PM20D1 0.9 16.9 0.72 5.68e-44 Menarche (age at onset); CESC cis rs8114671 0.836 rs734308 chr20:33572096 A/G cg06115741 chr20:33292138 TP53INP2 -0.46 -5.52 -0.32 8.18e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10635912 chr19:10305863 DNMT1 0.6 6.82 0.39 6.02e-11 Gut microbiome composition (summer); CESC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg00815214 chr21:47717953 NA -0.38 -5.42 -0.32 1.31e-7 Testicular germ cell tumor; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18022496 chr3:196594351 SENP5 0.46 6.14 0.35 2.95e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.89 13.75 0.65 7.91e-33 Prudent dietary pattern; CESC cis rs6598955 0.670 rs10794525 chr1:26537193 C/A cg00852783 chr1:26633632 UBXN11 0.41 5.97 0.34 7.44e-9 Obesity-related traits; CESC cis rs870825 0.860 rs28696121 chr4:185598743 G/A cg04058563 chr4:185651563 MLF1IP 0.6 6.11 0.35 3.53e-9 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04400030 chr15:64387986 SNX1 0.55 6.23 0.36 1.79e-9 Gut microbiome composition (summer); CESC cis rs13082711 0.596 rs683503 chr3:27348094 C/T cg02860705 chr3:27208620 NA 0.51 6.6 0.38 2.25e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs7914558 0.966 rs10786719 chr10:104637992 C/T cg04362960 chr10:104952993 NT5C2 -0.44 -5.52 -0.32 7.92e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2404602 0.684 rs8037847 chr15:76856551 C/T cg23625390 chr15:77176239 SCAPER -0.44 -6.13 -0.35 3.14e-9 Blood metabolite levels; CESC trans rs35110281 0.782 rs6518302 chr21:45018478 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 7.1 0.4 1.16e-11 Mean corpuscular volume; CESC cis rs17376456 0.877 rs10514380 chr5:93409370 C/T cg21475434 chr5:93447410 FAM172A 0.8 7.26 0.41 4.26e-12 Diabetic retinopathy; CESC cis rs10979 0.557 rs9285501 chr6:143915121 G/C cg25407410 chr6:143891975 LOC285740 -0.46 -6.05 -0.35 4.96e-9 Hypospadias; CESC trans rs11098499 0.754 rs1814813 chr4:120258207 G/T cg25214090 chr10:38739885 LOC399744 -0.58 -8.41 -0.46 2.55e-15 Corneal astigmatism; CESC cis rs17376456 0.690 rs6892055 chr5:93113023 A/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.59 5.05 0.3 8.04e-7 Diabetic retinopathy; CESC cis rs9303401 0.921 rs34102441 chr17:56877414 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.73 9.6 0.51 6.34e-19 Cognitive test performance; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07729303 chr15:22940817 CYFIP1 0.47 6.23 0.36 1.78e-9 Fibrinogen levels; CESC cis rs11098499 0.648 rs2002047 chr4:120257228 A/G cg09307838 chr4:120376055 NA 0.81 10.94 0.56 3.14e-23 Corneal astigmatism; CESC cis rs73019876 0.868 rs2262908 chr19:22134800 C/T cg11619707 chr19:22235551 ZNF257 -0.3 -5.68 -0.33 3.63e-8 Testicular germ cell tumor; CESC cis rs7662987 0.517 rs2851277 chr4:100022910 G/T cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.21e-14 Smoking initiation; CESC cis rs253959 0.729 rs1567335 chr5:115501792 C/T cg23108291 chr5:115420582 COMMD10 -0.42 -5.19 -0.3 4.11e-7 Bipolar disorder and schizophrenia; CESC cis rs2250402 0.510 rs8031319 chr15:40323692 A/G cg01081584 chr15:40268610 EIF2AK4 -0.59 -5.34 -0.31 2e-7 Corneal curvature; CESC trans rs931812 0.895 rs965625 chr8:101909749 T/C cg20993868 chr7:22813445 NA 0.56 8.03 0.44 3.25e-14 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs3540 0.533 rs2256097 chr15:90971331 A/T cg10434728 chr15:90938212 IQGAP1 0.39 6.86 0.39 4.98e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg08736216 chr1:53307985 ZYG11A 0.39 6.51 0.37 3.78e-10 Monocyte count; CESC cis rs2625529 0.607 rs2912231 chr15:72567957 G/T cg16672083 chr15:72433130 SENP8 -0.44 -5.78 -0.33 2.1e-8 Red blood cell count; CESC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg01475735 chr3:40494733 NA 0.46 5.98 0.34 7.28e-9 Renal cell carcinoma; CESC cis rs7589342 0.792 rs13426321 chr2:106500280 G/A cg14210321 chr2:106509881 NCK2 -0.47 -5.37 -0.31 1.71e-7 Addiction; CESC cis rs6460942 0.915 rs17444141 chr7:12460971 T/G cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs6964587 0.967 rs10953065 chr7:91808915 A/G cg01689657 chr7:91764605 CYP51A1 -0.31 -5.62 -0.33 4.85e-8 Breast cancer; CESC cis rs1976403 0.659 rs10799699 chr1:21820961 C/T cg02390115 chr1:21767211 NBPF3 0.4 5.79 0.33 2.01e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1499614 1.000 rs2707830 chr7:66167645 T/C cg18252515 chr7:66147081 NA -1.42 -14.62 -0.67 6.69e-36 Gout; CESC trans rs1814175 0.588 rs1721994 chr11:49914050 G/A cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg18016565 chr1:150552671 MCL1 0.35 5.08 0.3 7.01e-7 Melanoma; CESC cis rs738322 0.753 rs2267372 chr22:38598234 A/G cg17652424 chr22:38574118 PLA2G6 0.31 5.38 0.31 1.64e-7 Cutaneous nevi; CESC cis rs4803468 1.000 rs3816037 chr19:41918009 C/T cg09537434 chr19:41945824 ATP5SL -1.03 -18.3 -0.75 6.46e-49 Height; CESC trans rs13178541 0.810 rs7378848 chr5:135087025 C/T cg06130072 chr11:1036714 MUC6 0.33 6.09 0.35 3.89e-9 IgG glycosylation; CESC cis rs919433 0.854 rs13013049 chr2:198208664 C/T cg03934865 chr2:198174659 NA -0.42 -5.67 -0.33 3.77e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg04369109 chr6:150039330 LATS1 -0.38 -5.19 -0.3 4.09e-7 Lung cancer; CESC cis rs3540 0.512 rs3862434 chr15:91080387 C/T cg22089800 chr15:90895588 ZNF774 0.61 8.32 0.45 4.84e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs7828089 0.561 rs13266541 chr8:22266135 G/A cg23129673 chr8:22266227 SLC39A14 0.39 5.75 0.33 2.45e-8 Verbal declarative memory; CESC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg17724175 chr1:150552817 MCL1 0.45 7.33 0.41 2.84e-12 Tonsillectomy; CESC cis rs2933343 0.951 rs9871612 chr3:128570402 C/T cg25356066 chr3:128598488 ACAD9 0.51 6.17 0.35 2.52e-9 IgG glycosylation; CESC cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.48 0.32 9.87e-8 Colonoscopy-negative controls vs population controls; CESC cis rs12479064 0.724 rs11885942 chr2:100004165 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.69 -8.12 -0.45 1.75e-14 Chronic sinus infection; CESC cis rs7044106 0.791 rs10985000 chr9:123484115 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.34 5.55 0.32 6.77e-8 Hip circumference adjusted for BMI; CESC cis rs35110281 0.641 rs4819283 chr21:45083011 T/A cg01579765 chr21:45077557 HSF2BP -0.53 -8.85 -0.48 1.3e-16 Mean corpuscular volume; CESC cis rs6429082 0.818 rs696248 chr1:235668511 C/A cg26050004 chr1:235667680 B3GALNT2 0.66 8.15 0.45 1.43e-14 Adiposity; CESC cis rs826838 0.967 rs7963716 chr12:38876090 C/T cg13010199 chr12:38710504 ALG10B 0.61 8.46 0.46 1.86e-15 Heart rate; CESC cis rs2243480 1.000 rs1404147 chr7:65264524 C/T cg18252515 chr7:66147081 NA -1.15 -11.63 -0.58 1.57e-25 Diabetic kidney disease; CESC cis rs10911251 0.509 rs4652780 chr1:183105923 G/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.34 0.63 2.05e-31 Colorectal cancer; CESC cis rs7618915 0.501 rs55678971 chr3:52717229 T/A cg05564831 chr3:52568323 NT5DC2 0.48 7.34 0.41 2.55e-12 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06077741 chr3:43121458 C3orf39 -0.6 -6.7 -0.38 1.23e-10 Gut microbiome composition (summer); CESC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg06718696 chr17:78121285 EIF4A3 0.79 9.64 0.51 4.87e-19 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg11764359 chr7:65958608 NA -0.8 -12.02 -0.59 7.52e-27 Aortic root size; CESC cis rs9814567 1.000 rs9856693 chr3:134306913 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.41 -5.55 -0.32 7.09e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.24 0.53 5.92e-21 Prudent dietary pattern; CESC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.55 -0.37 2.99e-10 Life satisfaction; CESC cis rs4909189 1.000 rs71547530 chr7:158135503 A/G cg24154853 chr7:158122151 PTPRN2 0.51 6.43 0.37 5.99e-10 Response to amphetamines; CESC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg08859206 chr1:53392774 SCP2 0.64 9.35 0.5 3.74e-18 Monocyte count; CESC trans rs1814175 0.645 rs1851849 chr11:50012164 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -18.49 -0.75 1.41e-49 Height; CESC cis rs11690935 0.959 rs973889 chr2:172579954 A/G cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.86 -0.67 9.31e-37 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08072980 chr7:50450320 IKZF1 -0.56 -6.98 -0.39 2.35e-11 Gut microbiome composition (summer); CESC cis rs61931739 0.500 rs6488213 chr12:34393319 C/T cg23762105 chr12:34175262 ALG10 -0.39 -5.14 -0.3 5.26e-7 Morning vs. evening chronotype; CESC cis rs10392 0.543 rs58414555 chr20:37554152 A/C cg27552599 chr20:37590471 DHX35 0.37 5.56 0.32 6.44e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs826838 1.000 rs11183747 chr12:38822595 A/G cg26384229 chr12:38710491 ALG10B -0.83 -14.5 -0.67 1.73e-35 Heart rate; CESC trans rs5763662 1.000 rs5763854 chr22:30577589 A/G cg13174343 chr10:51767556 AGAP6 0.65 6.1 0.35 3.65e-9 LDL cholesterol levels;LDL cholesterol; CESC cis rs75920871 0.502 rs10790166 chr11:116779499 A/G cg06541888 chr11:116658840 ZNF259 0.44 5.27 0.31 2.77e-7 Subjective well-being; CESC cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg20503657 chr10:835505 NA 0.79 7.94 0.44 5.86e-14 Eosinophil percentage of granulocytes; CESC cis rs2933343 0.729 rs789231 chr3:128602847 A/G cg24203234 chr3:128598194 ACAD9 0.43 5.79 0.34 1.97e-8 IgG glycosylation; CESC cis rs35160687 0.644 rs17738058 chr2:86513203 G/C cg01119172 chr2:86362222 SNORD94;PTCD3 -0.38 -5.1 -0.3 6.45e-7 Night sleep phenotypes; CESC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg13206674 chr6:150067644 NUP43 0.42 5.76 0.33 2.31e-8 Lung cancer; CESC cis rs1538970 0.962 rs9429160 chr1:45827968 G/T cg03146154 chr1:46216737 IPP 0.46 5.47 0.32 1.03e-7 Platelet count; CESC cis rs7223966 1.000 rs7220821 chr17:61704147 G/A cg11494091 chr17:61959527 GH2 0.39 5.51 0.32 8.35e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4601790 0.601 rs12801636 chr11:65391317 C/T cg26668713 chr11:65405903 SIPA1 0.65 7.86 0.44 9.4e-14 Blood pressure (age interaction); CESC cis rs1691799 0.899 rs1168310 chr12:66726355 A/G cg16791601 chr12:66731901 HELB 0.62 10.01 0.52 3.26e-20 White blood cell count (basophil); CESC cis rs6582630 0.555 rs11182217 chr12:38480030 G/A cg13010199 chr12:38710504 ALG10B 0.49 6.37 0.36 8.46e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs6028335 0.502 rs7265661 chr20:37586842 G/T cg27552599 chr20:37590471 DHX35 0.38 5.57 0.32 6.39e-8 Alcohol and nicotine co-dependence; CESC cis rs17253792 0.822 rs80328469 chr14:56067701 G/A cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC trans rs1814175 0.904 rs1846289 chr11:49620253 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -17.94 -0.74 1.14e-47 Height; CESC cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg18850127 chr7:39170497 POU6F2 0.36 5.06 0.3 7.85e-7 IgG glycosylation; CESC cis rs2370759 1.000 rs16933177 chr10:32565705 G/A cg18270830 chr10:32634957 EPC1 0.73 6.99 0.39 2.16e-11 Sexual dysfunction (female); CESC cis rs9768139 0.733 rs34173461 chr7:158122175 C/G cg27057461 chr7:158136379 PTPRN2 -0.35 -5.51 -0.32 8.6e-8 Calcium levels; CESC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg10541313 chr22:46663664 TTC38 0.67 5.9 0.34 1.1e-8 LDL cholesterol;Cholesterol, total; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08278194 chr3:39497860 NA 0.47 6.36 0.36 8.89e-10 Fibrinogen levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22607980 chr1:89357197 GTF2B -0.46 -6.14 -0.35 3.03e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.05 0.3 8.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs796364 0.951 rs35618222 chr2:201065777 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.63 5.8 0.34 1.85e-8 Schizophrenia; CESC cis rs4727963 0.792 rs10953968 chr7:122716333 G/A cg03640110 chr7:122635026 TAS2R16 0.41 6.57 0.37 2.72e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg22920501 chr2:26401640 FAM59B -0.69 -8.44 -0.46 2.06e-15 Gut microbiome composition (summer); CESC cis rs854765 0.686 rs8065497 chr17:17782649 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.46 -6.08 -0.35 4.26e-9 Total body bone mineral density; CESC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg05564831 chr3:52568323 NT5DC2 0.48 7.64 0.42 4.06e-13 Bipolar disorder; CESC cis rs911555 0.755 rs2273702 chr14:103918182 C/G cg09975044 chr14:104007538 NA -0.46 -5.83 -0.34 1.59e-8 Intelligence (multi-trait analysis); CESC cis rs9926296 0.656 rs2376883 chr16:89826926 A/G cg27121462 chr16:89883253 FANCA 0.54 6.79 0.39 7.27e-11 Vitiligo; CESC cis rs754466 0.651 rs56138814 chr10:79625795 T/C cg17075019 chr10:79541650 NA -0.85 -13.12 -0.63 1.25e-30 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg04282206 chr17:62833786 PLEKHM1P 0.57 6.54 0.37 3.22e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7772486 0.686 rs9390347 chr6:146044747 G/T cg05347473 chr6:146136440 FBXO30 -0.52 -6.93 -0.39 3.22e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9583531 0.527 rs2391866 chr13:111363294 A/T cg15841412 chr13:111365552 ING1 0.52 6.74 0.38 1.01e-10 Coronary artery disease; CESC cis rs45535039 0.506 rs2511856 chr11:119144148 A/C cg23558831 chr11:118978103 C2CD2L -0.43 -5.23 -0.31 3.51e-7 Plateletcrit; CESC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg06074448 chr4:187884817 NA -0.37 -5.4 -0.31 1.5e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs2243480 1.000 rs7778911 chr7:65694506 T/C cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC cis rs1448094 0.511 rs56291271 chr12:86162287 G/A cg02569458 chr12:86230093 RASSF9 0.49 7.68 0.43 3.15e-13 Major depressive disorder; CESC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg18765753 chr7:1198926 ZFAND2A -0.43 -6.4 -0.37 7.1e-10 Longevity;Endometriosis; CESC cis rs9486719 1.000 rs3798295 chr6:97052164 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -8.4 -0.46 2.7e-15 Migraine;Coronary artery disease; CESC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.49 0.37 4.1e-10 Bipolar disorder; CESC cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.13 0.3 5.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs950776 0.518 rs8053 chr15:78841220 T/C cg24631222 chr15:78858424 CHRNA5 0.39 5.06 0.3 7.72e-7 Sudden cardiac arrest; CESC cis rs6542838 0.702 rs6739176 chr2:99536846 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.36 -0.31 1.78e-7 Fear of minor pain; CESC cis rs870825 0.550 rs59051283 chr4:185646476 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04983327 chr17:25289961 NA -0.43 -6.3 -0.36 1.24e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6495122 0.699 rs3784789 chr15:75082552 C/G cg09165964 chr15:75287851 SCAMP5 0.4 5.22 0.31 3.55e-7 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs3892630 0.588 rs2112917 chr19:33317543 C/T cg22980127 chr19:33182716 NUDT19 1.16 14.45 0.66 2.76e-35 Red blood cell traits; CESC cis rs9911578 0.835 rs58647683 chr17:56483194 T/C cg12560992 chr17:57184187 TRIM37 -0.89 -14.85 -0.67 1.07e-36 Intelligence (multi-trait analysis); CESC cis rs6754311 0.550 rs10173394 chr2:136522675 C/T cg07169764 chr2:136633963 MCM6 -0.73 -9.13 -0.49 1.78e-17 Mosquito bite size; CESC cis rs16866061 1.000 rs72972378 chr2:225372562 A/G cg12698349 chr2:225449008 CUL3 0.73 10.85 0.55 6e-23 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg13206674 chr6:150067644 NUP43 0.43 6.26 0.36 1.53e-9 Lung cancer; CESC cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg05265849 chr7:22767390 IL6 0.51 6.71 0.38 1.19e-10 Lung cancer; CESC cis rs6690583 0.562 rs76839162 chr1:85530021 A/G cg22153463 chr1:85462885 MCOLN2 0.72 6.93 0.39 3.2e-11 Serum sulfate level; CESC cis rs2230307 0.536 rs11166384 chr1:100439890 C/T cg24955406 chr1:100503596 HIAT1 0.55 5.48 0.32 9.85e-8 Carotid intima media thickness; CESC cis rs4803468 1.000 rs284649 chr19:41926838 C/T cg14132834 chr19:41945861 ATP5SL -0.67 -8.35 -0.46 3.74e-15 Height; CESC trans rs5756813 0.754 rs15691 chr22:38172380 C/A cg19894588 chr14:64061835 NA -0.7 -8.74 -0.47 2.75e-16 Optic cup area;Vertical cup-disc ratio; CESC cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.05 0.35 4.95e-9 Colorectal cancer; CESC cis rs6582630 0.576 rs4882372 chr12:38356609 C/A cg26384229 chr12:38710491 ALG10B -0.46 -6.06 -0.35 4.72e-9 Drug-induced liver injury (flucloxacillin); CESC trans rs11098499 0.954 rs6857105 chr4:120222298 C/G cg25214090 chr10:38739885 LOC399744 0.65 8.95 0.48 6.35e-17 Corneal astigmatism; CESC cis rs17253792 0.908 rs74354306 chr14:56065778 T/G cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs12477438 0.765 rs6722164 chr2:99561527 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.83 -0.48 1.47e-16 Chronic sinus infection; CESC cis rs367943 0.901 rs348951 chr5:112822017 G/C cg12552261 chr5:112820674 MCC -0.63 -7.94 -0.44 5.83e-14 Type 2 diabetes; CESC cis rs11750568 1.000 rs11750568 chr5:178535713 A/G cg10208897 chr5:178548229 ADAMTS2 0.39 5.49 0.32 9.51e-8 Height; CESC cis rs8067354 0.645 rs11079389 chr17:57887952 G/A cg13753209 chr17:57696993 CLTC 0.56 6.3 0.36 1.21e-9 Hemoglobin concentration; CESC cis rs12681288 0.823 rs12681230 chr8:994422 G/A cg15309053 chr8:964076 NA 0.32 5.37 0.31 1.73e-7 Schizophrenia; CESC cis rs4523957 0.651 rs9898819 chr17:2076352 G/A cg16513277 chr17:2031491 SMG6 -0.68 -9.44 -0.5 1.94e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1707322 1.000 rs1707337 chr1:46508769 A/G cg03146154 chr1:46216737 IPP -0.72 -9.73 -0.51 2.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg08888203 chr3:10149979 C3orf24 0.49 6.17 0.35 2.49e-9 Alzheimer's disease; CESC trans rs117533700 1.000 rs10423956 chr19:13170224 C/T cg24196017 chr15:43021976 CDAN1 -0.76 -6.03 -0.35 5.61e-9 Monocyte count; CESC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg03354898 chr7:1950403 MAD1L1 -0.31 -5.18 -0.3 4.49e-7 Bipolar disorder and schizophrenia; CESC cis rs4901869 0.966 rs4901868 chr14:59333792 C/T cg02291164 chr14:59296302 NA -0.44 -7.6 -0.42 4.97e-13 Panic disorder; CESC cis rs7660520 1.000 rs7660520 chr4:183745321 C/T cg07132183 chr4:182873955 NA 0.37 5.08 0.3 7.27e-7 Pediatric autoimmune diseases; CESC cis rs11608355 0.545 rs56144717 chr12:109902304 T/C cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs9467711 0.606 rs66827971 chr6:26365766 T/C cg14345882 chr6:26364793 BTN3A2 0.6 6.17 0.35 2.57e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2230307 0.536 rs640030 chr1:100574992 C/T cg24955406 chr1:100503596 HIAT1 -0.52 -5.13 -0.3 5.69e-7 Carotid intima media thickness; CESC trans rs1908814 0.516 rs13281315 chr8:11794855 C/G cg15556689 chr8:8085844 FLJ10661 0.51 6.33 0.36 1.02e-9 Neuroticism; CESC cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg26408565 chr15:76604113 ETFA -0.42 -6.08 -0.35 4.29e-9 Blood metabolite levels; CESC cis rs4253772 1.000 rs11705483 chr22:46630544 C/A cg00784671 chr22:46762841 CELSR1 -0.57 -5.63 -0.33 4.54e-8 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13885159 chr11:62473858 BSCL2;GNG3 0.65 7.87 0.44 9.35e-14 Gut microbiome composition (summer); CESC cis rs798554 0.704 rs709282 chr7:2769921 G/A cg09658497 chr7:2847517 GNA12 -0.36 -5.43 -0.32 1.24e-7 Height; CESC trans rs9858542 0.953 rs1873625 chr3:49666964 C/A cg21659725 chr3:3221576 CRBN -0.52 -6.31 -0.36 1.14e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg21573476 chr21:45109991 RRP1B -0.56 -8.45 -0.46 1.97e-15 Mean corpuscular volume; CESC trans rs7246760 0.609 rs12459250 chr19:9909543 C/T cg02900749 chr2:68251473 NA -0.73 -6.52 -0.37 3.46e-10 Pursuit maintenance gain; CESC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg10053473 chr17:62856997 LRRC37A3 0.66 9.26 0.49 7.05e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs17376456 0.825 rs28610997 chr5:93248374 T/C cg25358565 chr5:93447407 FAM172A 1.13 10.1 0.53 1.69e-20 Diabetic retinopathy; CESC trans rs61931739 0.500 rs11053271 chr12:34545407 C/A cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.1e-18 Prudent dietary pattern; CESC cis rs597539 0.690 rs11228383 chr11:68623228 T/G cg18350739 chr11:68623251 NA -0.46 -6.64 -0.38 1.73e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11958404 1.000 rs11958404 chr5:157410278 A/T cg05962755 chr5:157440814 NA 0.51 5.74 0.33 2.64e-8 IgG glycosylation; CESC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg11764359 chr7:65958608 NA -0.8 -11.89 -0.59 2.01e-26 Aortic root size; CESC cis rs5753618 0.539 rs5997933 chr22:31672752 A/C cg13145458 chr22:31556086 RNF185 0.48 5.36 0.31 1.8e-7 Colorectal cancer; CESC cis rs643506 1.000 rs4936675 chr11:111623088 T/A cg09085632 chr11:111637200 PPP2R1B 0.55 7.01 0.4 1.92e-11 Breast cancer; CESC cis rs1971256 0.500 rs3912290 chr6:151818297 T/G cg10883421 chr6:151773342 RMND1;C6orf211 0.63 6.03 0.35 5.34e-9 Endometriosis; CESC cis rs4986172 0.726 rs12051846 chr17:43226887 A/G cg10701640 chr17:43249399 NA 0.43 6.86 0.39 4.81e-11 Height; CESC cis rs6963495 0.818 rs73192113 chr7:105169603 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.5 -0.32 9.1e-8 Bipolar disorder (body mass index interaction); CESC cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg23221052 chr5:179740743 GFPT2 -0.63 -8.17 -0.45 1.31e-14 Height; CESC trans rs17132261 1.000 rs17132029 chr5:109702488 A/G cg17540356 chr11:69632220 FGF3 -0.61 -6.02 -0.35 5.82e-9 Cardiac structure and function;Left ventricle wall thickness; CESC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.45 5.29 0.31 2.52e-7 Renal function-related traits (BUN); CESC cis rs3806843 0.705 rs2530230 chr5:140088131 G/A cg16179182 chr5:140090404 VTRNA1-1 0.45 5.88 0.34 1.24e-8 Depressive symptoms (multi-trait analysis); CESC cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg24308560 chr3:49941425 MST1R 0.63 9.43 0.5 2.24e-18 Intelligence (multi-trait analysis); CESC cis rs1707322 0.717 rs10890345 chr1:46213927 C/T cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7843479 0.965 rs3816786 chr8:21860425 A/T cg17168535 chr8:21777572 XPO7 0.44 6.08 0.35 4.17e-9 Mean corpuscular volume; CESC cis rs449303 1 rs449303 chr14:60605788 A/G cg00846580 chr14:60632234 DHRS7 0.76 7.15 0.4 8.6e-12 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs2018683 0.834 rs733485 chr7:29026685 C/A cg19402173 chr7:128379420 CALU -0.6 -7.51 -0.42 8.79e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs7916410 0.512 rs1900003 chr10:70004551 A/C cg06988349 chr10:69991859 ATOH7 0.39 6.39 0.37 7.5e-10 Optic disc area; CESC cis rs539096 0.501 rs713191 chr1:44314553 A/G cg13606994 chr1:44402422 ARTN -0.35 -5.14 -0.3 5.31e-7 Intelligence (multi-trait analysis); CESC cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg03433033 chr1:76189801 ACADM 0.66 7.79 0.43 1.55e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7772486 0.624 rs9485018 chr6:146025731 T/C cg23711669 chr6:146136114 FBXO30 -0.86 -12.62 -0.61 6.46e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs1580019 0.961 rs766657 chr7:32499510 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.11 0.53 1.51e-20 Cognitive ability; CESC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg12524338 chr4:183729343 NA 0.51 5.3 0.31 2.4e-7 Pediatric autoimmune diseases; CESC cis rs3820068 0.705 rs4646091 chr1:15822043 T/C cg17385448 chr1:15911702 AGMAT 0.39 6.18 0.35 2.44e-9 Systolic blood pressure; CESC cis rs738322 0.804 rs4821743 chr22:38514906 A/G cg17652424 chr22:38574118 PLA2G6 -0.29 -5.1 -0.3 6.59e-7 Cutaneous nevi; CESC cis rs7580658 0.613 rs12478656 chr2:128196520 G/T cg10021288 chr2:128175891 PROC -0.4 -5.95 -0.34 8.5e-9 Protein C levels; CESC cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg12373951 chr3:133503437 NA 0.51 7.56 0.42 6.74e-13 Iron status biomarkers; CESC cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg03433033 chr1:76189801 ACADM -0.56 -6.06 -0.35 4.61e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3749237 0.595 rs11130196 chr3:49490149 A/C cg07636037 chr3:49044803 WDR6 0.64 9.28 0.5 6.11e-18 Resting heart rate; CESC cis rs2933343 0.700 rs1683777 chr3:128624880 T/G cg24203234 chr3:128598194 ACAD9 0.39 5.25 0.31 3.19e-7 IgG glycosylation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03383661 chr6:42714115 TBCC 0.52 6.74 0.38 9.91e-11 Gut microbiota (bacterial taxa); CESC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.35 0.81 6.51e-63 Prudent dietary pattern; CESC cis rs727505 0.909 rs1031957 chr7:124627301 T/C cg23710748 chr7:124431027 NA -0.45 -7.05 -0.4 1.51e-11 Lewy body disease; CESC cis rs4654899 0.758 rs4457549 chr1:21487231 A/G cg05370193 chr1:21551575 ECE1 -0.38 -5.68 -0.33 3.47e-8 Superior frontal gyrus grey matter volume; CESC cis rs55728055 0.661 rs55894054 chr22:31976299 T/C cg01338084 chr22:32026380 PISD 1.26 8.55 0.47 9.7e-16 Age-related hearing impairment; CESC cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg01475377 chr6:109611718 NA -0.52 -8.56 -0.47 9.05e-16 Reticulocyte fraction of red cells; CESC cis rs9790314 1.000 rs336543 chr3:161061080 C/T cg04691961 chr3:161091175 C3orf57 0.45 5.8 0.34 1.91e-8 Morning vs. evening chronotype; CESC cis rs7937682 0.774 rs59921976 chr11:111473088 G/A cg22437258 chr11:111473054 SIK2 0.74 9.81 0.52 1.38e-19 Primary sclerosing cholangitis; CESC cis rs3936840 0.514 rs8007356 chr14:102975266 G/A cg18135206 chr14:102964638 TECPR2 0.46 5.87 0.34 1.29e-8 Plateletcrit; CESC cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg16339924 chr4:17578868 LAP3 0.66 8.45 0.46 1.95e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.38 -5.74 -0.33 2.59e-8 Personality dimensions; CESC cis rs6963495 0.818 rs711430 chr7:105167969 A/G cg13798780 chr7:105162888 PUS7 0.6 6.94 0.39 2.96e-11 Bipolar disorder (body mass index interaction); CESC cis rs9596863 1.000 rs9596862 chr13:54432908 A/G ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg05332525 chr7:65337924 VKORC1L1 0.52 6.41 0.37 6.6e-10 Calcium levels; CESC cis rs11098499 0.909 rs28793658 chr4:120307214 A/C cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs113835537 0.529 rs3741360 chr11:66300348 A/G cg24851651 chr11:66362959 CCS 0.5 5.98 0.34 7.08e-9 Airway imaging phenotypes; CESC cis rs2204008 0.782 rs117824012 chr12:38215517 T/C cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg16325326 chr1:53192061 ZYG11B 0.9 15.22 0.68 5.29e-38 Monocyte count; CESC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg23803603 chr1:2058230 PRKCZ -0.31 -5.32 -0.31 2.26e-7 Height; CESC cis rs1538970 0.924 rs1006216 chr1:45909994 A/G cg03146154 chr1:46216737 IPP 0.46 5.34 0.31 1.97e-7 Platelet count; CESC cis rs7809950 0.678 rs62483641 chr7:106901741 T/C cg23024343 chr7:107201750 COG5 -0.54 -6.79 -0.38 7.55e-11 Coronary artery disease; CESC cis rs853679 0.882 rs3757188 chr6:28107357 T/C cg26335602 chr6:28129616 ZNF389 0.53 5.23 0.31 3.42e-7 Depression; CESC trans rs2727020 0.553 rs3907576 chr11:49536639 A/C cg15704280 chr7:45808275 SEPT13 -0.94 -16.08 -0.7 4.42e-41 Coronary artery disease; CESC cis rs11122272 0.735 rs2808592 chr1:231523757 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs7927771 0.839 rs11039308 chr11:47622412 G/A cg05585544 chr11:47624801 NA -0.42 -6.58 -0.37 2.54e-10 Subjective well-being; CESC cis rs72949976 0.966 rs6752061 chr2:214027818 C/T cg08319019 chr2:214017104 IKZF2 -0.45 -5.76 -0.33 2.34e-8 Lung cancer;Squamous cell lung carcinoma; CESC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg04267008 chr7:1944627 MAD1L1 -0.62 -7.46 -0.42 1.27e-12 Bipolar disorder and schizophrenia; CESC cis rs2228479 0.681 rs8044906 chr16:89969603 T/C cg04013166 chr16:89971882 TCF25 0.69 8.01 0.44 3.67e-14 Skin colour saturation; CESC cis rs11718455 0.960 rs11929518 chr3:44016874 A/G cg08738300 chr3:44038990 NA 0.47 5.98 0.35 7.01e-9 Coronary artery disease; CESC cis rs9790314 0.765 rs4856768 chr3:161004392 G/A cg03342759 chr3:160939853 NMD3 -0.46 -6.29 -0.36 1.28e-9 Morning vs. evening chronotype; CESC cis rs11247915 0.600 rs3795686 chr1:26582091 G/A cg04990556 chr1:26633338 UBXN11 -0.64 -7.08 -0.4 1.26e-11 Obesity-related traits; CESC cis rs2487048 0.725 rs2246293 chr9:107690838 C/G cg14470647 chr9:107690075 ABCA1 0.58 7.35 0.41 2.44e-12 Intraocular pressure; CESC cis rs2425143 0.908 rs58448091 chr20:34325470 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.51 -0.42 9.02e-13 Blood protein levels; CESC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg24060327 chr5:131705240 SLC22A5 -0.41 -5.15 -0.3 5.07e-7 Blood metabolite levels; CESC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg11764359 chr7:65958608 NA -0.7 -9.73 -0.51 2.51e-19 Aortic root size; CESC cis rs643506 0.874 rs613292 chr11:111668805 C/T cg09085632 chr11:111637200 PPP2R1B 0.39 5.12 0.3 5.9e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17184704 chr10:11727286 NA -0.59 -6.95 -0.39 2.75e-11 Gut microbiome composition (summer); CESC cis rs1707322 0.929 rs785500 chr1:46593044 C/T cg03146154 chr1:46216737 IPP -0.69 -9.13 -0.49 1.84e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1814175 0.645 rs1721997 chr11:49916653 T/C cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs1008375 0.931 rs979823 chr4:17700176 G/A cg16339924 chr4:17578868 LAP3 0.62 7.63 0.42 4.31e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs17376456 0.825 rs28705226 chr5:93233135 T/C cg21475434 chr5:93447410 FAM172A 0.74 6.6 0.38 2.26e-10 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11649068 chr17:34136647 TAF15 0.57 6.97 0.39 2.46e-11 Gut microbiome composition (summer); CESC cis rs6963495 0.818 rs117845382 chr7:105152040 T/C cg19920283 chr7:105172520 RINT1 0.67 6.36 0.36 8.79e-10 Bipolar disorder (body mass index interaction); CESC cis rs10206020 0.879 rs72778007 chr2:1573178 C/T cg26248373 chr2:1572462 NA -0.61 -7.13 -0.4 9.41e-12 IgG glycosylation; CESC cis rs4835473 0.932 rs1473055 chr4:144918867 A/G cg25736465 chr4:144833511 NA 0.42 6.28 0.36 1.38e-9 Immature fraction of reticulocytes; CESC cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg20476274 chr7:133979776 SLC35B4 0.68 9.88 0.52 8.59e-20 Mean platelet volume; CESC cis rs3768617 1.000 rs2027077 chr1:183073453 G/C ch.1.3577855R chr1:183094577 LAMC1 0.66 9.34 0.5 4.21e-18 Fuchs's corneal dystrophy; CESC cis rs17376456 0.877 rs12716456 chr5:93397557 A/G cg25358565 chr5:93447407 FAM172A 1.11 11.19 0.57 4.56e-24 Diabetic retinopathy; CESC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg23048001 chr7:2026167 MAD1L1 0.46 6.0 0.35 6.39e-9 Bipolar disorder and schizophrenia; CESC cis rs6738485 0.507 rs66569888 chr2:106886967 G/A cg15412446 chr2:106886593 NA -0.67 -6.4 -0.37 6.9e-10 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CESC cis rs4595586 0.632 rs1356266 chr12:39403581 A/G cg26384229 chr12:38710491 ALG10B -0.4 -5.72 -0.33 2.86e-8 Morning vs. evening chronotype; CESC cis rs2130392 0.924 rs873687 chr4:185638853 G/A cg21366198 chr4:185655624 MLF1IP 0.42 5.86 0.34 1.37e-8 Kawasaki disease; CESC cis rs4711336 1.000 rs2229642 chr6:33659472 C/G cg14003231 chr6:33640908 ITPR3 0.32 5.42 0.32 1.34e-7 Height; CESC cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg06970220 chr1:156163860 SLC25A44 0.39 5.22 0.31 3.67e-7 Testicular germ cell tumor; CESC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.76 0.59 5.62e-26 Alzheimer's disease; CESC cis rs6582630 0.519 rs12819814 chr12:38332568 G/C cg13010199 chr12:38710504 ALG10B 0.45 5.82 0.34 1.69e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs2243480 1.000 rs4145008 chr7:65647511 T/G cg13147721 chr7:65941812 NA 0.97 9.16 0.49 1.47e-17 Diabetic kidney disease; CESC cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg15782153 chr7:917662 C7orf20 0.53 5.6 0.33 5.47e-8 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11346722 chr6:34512215 SPDEF -0.49 -6.65 -0.38 1.67e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg00166722 chr3:10149974 C3orf24 0.52 6.38 0.36 7.91e-10 Alzheimer's disease; CESC cis rs208520 0.526 rs6913344 chr6:66754285 A/C cg07460842 chr6:66804631 NA -1.01 -20.77 -0.79 1.56e-57 Exhaled nitric oxide output; CESC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs11112613 0.762 rs73184078 chr12:105950017 A/G cg03607813 chr12:105948248 NA 0.67 8.31 0.45 5.16e-15 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs6674176 0.569 rs34830883 chr1:44405339 T/C cg12908607 chr1:44402522 ARTN -0.49 -7.48 -0.42 1.09e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22338127 chr1:209979572 IRF6 0.56 8.78 0.47 2.05e-16 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs7208859 0.623 rs9915566 chr17:29132158 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs896854 0.517 rs2013597 chr8:95951807 G/A cg16049864 chr8:95962084 TP53INP1 -0.54 -7.64 -0.42 3.92e-13 Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08891424 chr2:190648631 ORMDL1;PMS1 -0.41 -6.21 -0.36 2.06e-9 Gambling; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27359633 chr20:33104463 DYNLRB1 -0.38 -6.11 -0.35 3.48e-9 Gambling; CESC cis rs11690935 0.959 rs2292815 chr2:172586651 C/G cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.09 -0.65 4.92e-34 Schizophrenia; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg14091419 chr15:28356810 HERC2 0.46 6.5 0.37 3.89e-10 Prevalent atrial fibrillation; CESC cis rs7216064 1.000 rs62084238 chr17:65856573 T/A cg12091567 chr17:66097778 LOC651250 -0.83 -8.3 -0.45 5.54e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs11098499 0.821 rs28665282 chr4:120384186 C/T cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.05e-8 Corneal astigmatism; CESC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9388451 0.807 rs1268070 chr6:126041164 A/G cg05901451 chr6:126070800 HEY2 -0.6 -8.3 -0.45 5.25e-15 Brugada syndrome; CESC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg22800045 chr5:56110881 MAP3K1 0.49 5.88 0.34 1.24e-8 Coronary artery disease; CESC cis rs7258465 1.000 rs10164319 chr19:18569833 G/A cg25828334 chr19:18545568 ISYNA1 -0.32 -5.16 -0.3 4.8e-7 Breast cancer; CESC cis rs2235642 0.691 rs2281235 chr16:1603535 T/C cg03771183 chr16:1608904 IFT140 0.41 5.95 0.34 8.47e-9 Coronary artery disease; CESC cis rs7927771 0.965 rs4752881 chr11:47898535 A/G cg18512352 chr11:47633146 NA -0.62 -9.65 -0.51 4.44e-19 Subjective well-being; CESC cis rs854765 0.547 rs2955385 chr17:17939247 C/T cg16928487 chr17:17741425 SREBF1 -0.55 -9.28 -0.5 6.45e-18 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15652989 chr16:69222106 SNTB2 -0.54 -6.08 -0.35 4.2e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.591 rs113101219 chr22:46659186 C/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.6 5.29 0.31 2.61e-7 LDL cholesterol;Cholesterol, total; CESC cis rs372883 0.530 rs2832302 chr21:30749793 G/T cg24692254 chr21:30365293 RNF160 -0.49 -6.06 -0.35 4.64e-9 Pancreatic cancer; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg19434433 chr17:44849214 WNT3 0.44 6.21 0.36 2.09e-9 Thyroid stimulating hormone; CESC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.11e-8 Alzheimer's disease; CESC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg11657440 chr19:46296263 DMWD 0.78 11.89 0.59 2.1e-26 Coronary artery disease; CESC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg02564969 chr6:151773285 C6orf211;RMND1 0.62 8.49 0.46 1.49e-15 Menarche (age at onset); CESC cis rs6736093 0.966 rs11679801 chr2:112712835 G/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.3 -0.31 2.49e-7 Coronary artery disease; CESC cis rs10227331 1.000 rs10227331 chr7:157294938 A/T cg04156418 chr7:157293606 NA 0.31 5.26 0.31 2.96e-7 Inattentive symptoms; CESC cis rs6570726 0.791 rs6570695 chr6:145911286 C/A cg23711669 chr6:146136114 FBXO30 0.92 13.58 0.64 3.16e-32 Lobe attachment (rater-scored or self-reported); CESC trans rs1728785 0.901 rs1170444 chr16:68573287 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.44 0.42 1.41e-12 Ulcerative colitis; CESC cis rs17666538 0.636 rs10107345 chr8:603700 G/T cg07685180 chr8:600429 NA 0.6 5.23 0.31 3.52e-7 IgG glycosylation; CESC cis rs9902453 0.691 rs140701 chr17:28538532 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 6.19 0.36 2.29e-9 Coffee consumption (cups per day); CESC cis rs400736 0.671 rs2131630 chr1:7990367 G/A cg25007680 chr1:8021821 PARK7 -0.57 -8.16 -0.45 1.35e-14 Response to antidepressants and depression; CESC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg11644478 chr21:40555479 PSMG1 -0.78 -11.45 -0.58 6.12e-25 Cognitive function; CESC cis rs9905704 0.681 rs2680710 chr17:56552902 A/G cg12560992 chr17:57184187 TRIM37 -0.62 -5.8 -0.34 1.86e-8 Testicular germ cell tumor; CESC cis rs2050392 0.590 rs694346 chr10:30711929 C/T cg25182066 chr10:30743637 MAP3K8 -0.46 -5.91 -0.34 1.03e-8 Inflammatory bowel disease; CESC cis rs897080 0.552 rs1067326 chr2:44628605 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.81 0.39 6.58e-11 Bipolar disorder; CESC cis rs6723226 0.765 rs12612824 chr2:32579759 C/T cg02381751 chr2:32503542 YIPF4 -0.91 -12.8 -0.62 1.55e-29 Intelligence (multi-trait analysis); CESC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg23743428 chr13:21893420 NA -0.38 -6.1 -0.35 3.69e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.35e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6570726 0.516 rs10457779 chr6:145736663 C/T cg23711669 chr6:146136114 FBXO30 0.54 6.76 0.38 8.53e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18103236 chr10:81060645 ZMIZ1 0.46 6.19 0.36 2.23e-9 Fibrinogen levels; CESC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg13880726 chr7:1868755 MAD1L1 0.4 5.28 0.31 2.72e-7 Bipolar disorder and schizophrenia; CESC cis rs892961 0.932 rs67415822 chr17:75412678 A/G cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs117623576 0.941 rs17488859 chr10:32386072 A/G cg03047570 chr10:32398778 NA 0.72 6.7 0.38 1.25e-10 Anti-saccade response; CESC cis rs9287719 0.967 rs10203785 chr2:10752508 T/C cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg02569458 chr12:86230093 RASSF9 0.48 7.11 0.4 1.07e-11 Major depressive disorder; CESC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 5.76 0.33 2.39e-8 Bipolar disorder; CESC cis rs72781680 0.752 rs72780185 chr2:24003967 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs12477438 0.520 rs6741773 chr2:99738962 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.15 0.68 9.04e-38 Chronic sinus infection; CESC cis rs8064299 0.967 rs878906 chr17:72769334 T/C cg25054828 chr17:72772726 NAT9;TMEM104 0.64 9.21 0.49 9.94e-18 Monocyte count; CESC cis rs10979 0.557 rs9390120 chr6:143909411 A/G cg25407410 chr6:143891975 LOC285740 -0.49 -6.46 -0.37 4.95e-10 Hypospadias; CESC cis rs9911578 1.000 rs10401050 chr17:56953786 A/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.96 -0.39 2.6e-11 Intelligence (multi-trait analysis); CESC cis rs7474896 0.515 rs662928 chr10:38316216 G/T cg25427524 chr10:38739819 LOC399744 0.48 5.48 0.32 9.76e-8 Obesity (extreme); CESC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg02187348 chr16:89574699 SPG7 0.64 8.94 0.48 7.01e-17 Multiple myeloma (IgH translocation); CESC cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg06212747 chr3:49208901 KLHDC8B 0.71 9.36 0.5 3.59e-18 Parkinson's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16066696 chr14:77843743 C14orf174;TMED8 -0.39 -6.21 -0.36 2e-9 Gambling; CESC cis rs34779708 0.966 rs2126984 chr10:35410291 A/G cg04310649 chr10:35416472 CREM -0.57 -6.79 -0.39 7.2e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg25405998 chr7:65216604 CCT6P1 -0.46 -5.22 -0.31 3.71e-7 Aortic root size; CESC cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg06636001 chr8:8085503 FLJ10661 0.49 6.34 0.36 9.85e-10 Mood instability; CESC trans rs9325144 0.560 rs12424821 chr12:38649951 C/T cg23762105 chr12:34175262 ALG10 0.48 6.23 0.36 1.81e-9 Morning vs. evening chronotype; CESC cis rs11190604 0.943 rs7085261 chr10:102209811 G/A cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs2228479 0.717 rs2270460 chr16:89972416 C/A cg04013166 chr16:89971882 TCF25 0.72 7.09 0.4 1.2e-11 Skin colour saturation; CESC cis rs12681288 0.782 rs2600500 chr8:1029031 G/C cg04851639 chr8:1020857 NA -0.43 -9.0 -0.48 4.57e-17 Schizophrenia; CESC cis rs7264396 0.563 rs2425120 chr20:34324456 A/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.86 0.39 4.77e-11 Total cholesterol levels; CESC cis rs12681288 0.676 rs2701923 chr8:994605 A/G cg04851639 chr8:1020857 NA -0.34 -7.38 -0.41 2.01e-12 Schizophrenia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19508191 chr12:109124361 CORO1C -0.45 -6.05 -0.35 5.05e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02565672 chr1:161123809 UFC1 0.58 6.24 0.36 1.76e-9 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs7220289 chr17:29103762 G/T cg19761014 chr17:28927070 LRRC37B2 0.75 6.14 0.35 2.95e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg25985355 chr7:65971099 NA 0.33 5.39 0.31 1.53e-7 Aortic root size; CESC cis rs9287719 0.967 rs2287061 chr2:10743153 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs7714584 1.000 rs1428554 chr5:150257616 A/G cg22134413 chr5:150180641 NA 0.5 5.82 0.34 1.7e-8 Crohn's disease; CESC cis rs2228479 0.702 rs62052710 chr16:89854893 C/T cg00800038 chr16:89945340 TCF25 -0.9 -7.5 -0.42 9.55e-13 Skin colour saturation; CESC cis rs34779708 0.966 rs10827487 chr10:35406878 T/A cg03585969 chr10:35415529 CREM 0.78 10.41 0.54 1.74e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs7824557 0.602 rs7839053 chr8:11207431 C/T cg21775007 chr8:11205619 TDH 0.57 8.65 0.47 5.01e-16 Retinal vascular caliber; CESC cis rs56046484 1.000 rs12911330 chr15:85630334 T/G cg08123816 chr15:85640762 PDE8A -0.5 -6.02 -0.35 5.81e-9 Testicular germ cell tumor; CESC cis rs9649465 1.000 rs10238422 chr7:123353708 G/C cg04330084 chr7:123175371 IQUB -0.38 -5.19 -0.3 4.21e-7 Migraine; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09325174 chr14:50154983 POLE2 0.57 6.43 0.37 6.04e-10 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11255513 chr11:113644528 ZW10 0.47 6.48 0.37 4.54e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2635047 0.713 rs9950812 chr18:44765943 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.7 0.33 3.25e-8 Educational attainment; CESC cis rs9467711 0.606 rs9379855 chr6:26364930 C/T cg12826209 chr6:26865740 GUSBL1 -0.57 -5.13 -0.3 5.47e-7 Autism spectrum disorder or schizophrenia; CESC cis rs3857067 0.806 rs11943926 chr4:95136512 G/A cg11021082 chr4:95130006 SMARCAD1 -0.65 -10.22 -0.53 7.09e-21 QT interval; CESC trans rs629535 0.814 rs62513381 chr8:70110991 T/C cg21567404 chr3:27674614 NA -0.87 -10.05 -0.53 2.43e-20 Dupuytren's disease; CESC cis rs11785400 0.762 rs7017931 chr8:143726728 A/G cg24634471 chr8:143751801 JRK 0.46 5.82 0.34 1.73e-8 Schizophrenia; CESC cis rs709400 0.627 rs62007686 chr14:103899344 A/G cg12935359 chr14:103987150 CKB -0.55 -7.97 -0.44 4.6e-14 Body mass index; CESC cis rs911555 0.755 rs9671414 chr14:103967299 C/T cg12935359 chr14:103987150 CKB 0.58 7.8 0.43 1.43e-13 Intelligence (multi-trait analysis); CESC cis rs7089973 0.624 rs11196930 chr10:116583596 C/T cg23260525 chr10:116636907 FAM160B1 0.38 6.86 0.39 4.73e-11 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9303401 0.659 rs62083410 chr17:56964386 T/C cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.69 0.61 3.78e-29 Cognitive test performance; CESC cis rs13064447 0.874 rs13058951 chr3:12752381 C/T cg23032965 chr3:12705835 RAF1 0.43 5.46 0.32 1.09e-7 Major depression and alcohol dependence; CESC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.12 -0.4 1.02e-11 Developmental language disorder (linguistic errors); CESC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg09491104 chr22:46646882 C22orf40 -0.52 -6.43 -0.37 5.82e-10 LDL cholesterol;Cholesterol, total; CESC cis rs854765 0.583 rs4077198 chr17:17834563 T/C cg16928487 chr17:17741425 SREBF1 -0.57 -9.74 -0.51 2.33e-19 Total body bone mineral density; CESC cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg00290607 chr11:67383545 NA 0.45 6.35 0.36 9.21e-10 Mean corpuscular volume; CESC cis rs13223928 0.565 rs10951053 chr7:3155579 C/T cg19214707 chr7:3157722 NA -0.46 -6.13 -0.35 3.22e-9 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg23048001 chr7:2026167 MAD1L1 0.46 5.96 0.34 8.11e-9 Bipolar disorder and schizophrenia; CESC cis rs3096299 0.781 rs2170839 chr16:89409452 C/G cg08822215 chr16:89438651 ANKRD11 -0.4 -5.8 -0.34 1.93e-8 Multiple myeloma (IgH translocation); CESC cis rs2262909 0.889 rs61268244 chr19:22310130 C/T cg11619707 chr19:22235551 ZNF257 0.33 5.31 0.31 2.35e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs11718455 1.000 rs11917515 chr3:44020237 A/G cg08738300 chr3:44038990 NA 0.45 5.81 0.34 1.78e-8 Coronary artery disease; CESC cis rs9902453 0.900 rs12451122 chr17:28486376 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.55 0.42 6.98e-13 Coffee consumption (cups per day); CESC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg14159672 chr1:205819179 PM20D1 0.81 12.95 0.62 4.67e-30 Menarche (age at onset); CESC cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg10556349 chr10:835070 NA 0.55 5.89 0.34 1.16e-8 Eosinophil percentage of granulocytes; CESC cis rs12477438 0.784 rs13407840 chr2:99569928 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.66 -0.47 4.81e-16 Chronic sinus infection; CESC cis rs7103648 0.712 rs10838703 chr11:47422861 C/G cg20307385 chr11:47447363 PSMC3 0.87 13.32 0.63 2.44e-31 Diastolic blood pressure;Systolic blood pressure; CESC cis rs3126085 0.935 rs11586114 chr1:152299767 G/A cg03465714 chr1:152285911 FLG 0.49 5.46 0.32 1.11e-7 Atopic dermatitis; CESC cis rs3806843 0.966 rs2563266 chr5:140136915 C/A cg26395211 chr5:140044315 WDR55 0.44 5.59 0.32 5.7e-8 Depressive symptoms (multi-trait analysis); CESC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg11644478 chr21:40555479 PSMG1 1.06 17.86 0.74 2.19e-47 Cognitive function; CESC cis rs910316 1.000 rs4903284 chr14:75592483 G/C cg11812906 chr14:75593930 NEK9 0.89 15.03 0.68 2.4e-37 Height; CESC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 5.02e-9 Prudent dietary pattern; CESC cis rs4566357 0.615 rs3769643 chr2:227917270 T/C cg05526886 chr2:227700861 RHBDD1 -0.52 -6.83 -0.39 5.73e-11 Coronary artery disease; CESC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg12648201 chr2:27665141 KRTCAP3 -0.36 -6.72 -0.38 1.11e-10 Total body bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01956158 chr8:132916947 EFR3A 0.5 6.3 0.36 1.27e-9 Gut microbiota (bacterial taxa); CESC cis rs11030122 0.702 rs1349583 chr11:3972236 G/A cg18678763 chr11:4115507 RRM1 -0.46 -6.12 -0.35 3.33e-9 Mean platelet volume;Platelet distribution width; CESC cis rs9303401 0.659 rs7210432 chr17:56668170 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.56e-29 Cognitive test performance; CESC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg06456125 chr7:65229604 NA -0.4 -5.27 -0.31 2.8e-7 Aortic root size; CESC cis rs80282103 0.618 rs76068439 chr10:1121018 T/A cg08668510 chr10:1095578 IDI1 0.95 5.3 0.31 2.46e-7 Glomerular filtration rate (creatinine); CESC cis rs4927850 0.752 rs7624460 chr3:195748530 C/T cg01181863 chr3:195395398 SDHAP2 -0.55 -6.55 -0.37 2.91e-10 Pancreatic cancer; CESC cis rs9929218 0.954 rs112225541 chr16:68755165 C/T cg02972257 chr16:68554789 NA 0.55 6.41 0.37 6.69e-10 Colorectal cancer; CESC cis rs17021463 0.966 rs10856908 chr4:95222755 G/T cg11021082 chr4:95130006 SMARCAD1 -0.63 -10.45 -0.54 1.22e-21 Testicular germ cell tumor; CESC cis rs6499188 0.522 rs8046299 chr16:68672346 G/A cg02972257 chr16:68554789 NA -0.6 -6.95 -0.39 2.86e-11 Ulcerative colitis; CESC cis rs798766 1.000 rs11729657 chr4:1737585 T/C cg10756475 chr4:1757242 NA 0.47 6.51 0.37 3.69e-10 Bladder cancer;Urinary bladder cancer; CESC cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg08508325 chr11:3079039 CARS -0.57 -10.67 -0.55 2.46e-22 Longevity; CESC trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21659725 chr3:3221576 CRBN -0.82 -13.49 -0.64 6.48e-32 Intelligence (multi-trait analysis); CESC cis rs2380220 0.541 rs72928277 chr6:96079745 G/T cg04719120 chr6:96025338 MANEA -0.64 -6.74 -0.38 1.01e-10 Behavioural disinhibition (generation interaction); CESC cis rs67311347 1.000 rs6795475 chr3:40489281 A/G cg09455208 chr3:40491958 NA 0.45 7.59 0.42 5.38e-13 Renal cell carcinoma; CESC cis rs2249694 0.960 rs7094588 chr10:135401586 A/G cg19469447 chr10:135341870 CYP2E1 0.36 5.17 0.3 4.72e-7 Obesity-related traits; CESC cis rs6545883 0.965 rs2305155 chr2:61729258 A/G cg15711740 chr2:61764176 XPO1 -0.41 -5.09 -0.3 6.76e-7 Tuberculosis; CESC cis rs1153858 0.895 rs12593402 chr15:45617392 G/A cg21132104 chr15:45694354 SPATA5L1 0.82 10.84 0.55 6.43e-23 Homoarginine levels; CESC cis rs1707322 0.752 rs4586014 chr1:46150443 A/G cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs208520 0.690 rs1100981 chr6:66852052 T/C cg07460842 chr6:66804631 NA -1.01 -13.48 -0.64 6.84e-32 Exhaled nitric oxide output; CESC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg16489826 chr6:160211363 TCP1;MRPL18 0.85 12.01 0.59 8.38e-27 Age-related macular degeneration (geographic atrophy); CESC cis rs7927592 0.731 rs11228275 chr11:68303980 G/A cg20283391 chr11:68216788 NA 0.43 5.54 0.32 7.11e-8 Total body bone mineral density; CESC cis rs8017423 0.967 rs28424204 chr14:90705669 G/C cg14092571 chr14:90743983 NA -0.58 -8.54 -0.46 1.04e-15 Mortality in heart failure; CESC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg23172400 chr8:95962367 TP53INP1 -0.44 -9.16 -0.49 1.43e-17 Type 2 diabetes; CESC cis rs8060686 0.641 rs12448677 chr16:68209741 G/A cg26727032 chr16:67993705 SLC12A4 -0.53 -6.03 -0.35 5.55e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg08993922 chr7:2212490 MAD1L1 0.38 5.39 0.31 1.59e-7 Bipolar disorder and schizophrenia; CESC cis rs57221529 0.709 rs111352378 chr5:577079 G/A cg16447950 chr5:562315 NA -0.64 -6.81 -0.39 6.59e-11 Lung disease severity in cystic fibrosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06473843 chr1:32757546 HDAC1 0.52 6.22 0.36 1.9e-9 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg11764359 chr7:65958608 NA -0.78 -11.64 -0.58 1.47e-25 Aortic root size; CESC cis rs863345 0.604 rs2054992 chr1:158506015 G/A cg12129480 chr1:158549410 OR10X1 -0.33 -6.61 -0.38 2.11e-10 Pneumococcal bacteremia; CESC trans rs634534 0.561 rs613924 chr11:65769295 C/T cg17712092 chr4:129076599 LARP1B 0.73 10.25 0.53 5.63e-21 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs1215050 0.874 rs17545594 chr4:98652689 A/G cg05340658 chr4:99064831 C4orf37 -0.49 -5.96 -0.34 8.03e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2070997 0.607 rs11244140 chr9:133663058 T/C cg11464064 chr9:133710261 ABL1 0.51 5.53 0.32 7.49e-8 Response to amphetamines; CESC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg16325326 chr1:53192061 ZYG11B 0.89 15.11 0.68 1.2e-37 Monocyte count; CESC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg13798912 chr7:905769 UNC84A -0.56 -5.65 -0.33 4.04e-8 Cerebrospinal P-tau181p levels; CESC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg07343612 chr16:622815 PIGQ -0.54 -7.98 -0.44 4.5e-14 Height; CESC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg10792982 chr14:105748885 BRF1 0.41 5.74 0.33 2.52e-8 Mean platelet volume;Platelet distribution width; CESC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg00684032 chr4:1343700 KIAA1530 0.42 6.45 0.37 5.29e-10 Longevity; CESC cis rs1185460 0.565 rs540261 chr11:118947634 C/T cg23280166 chr11:118938394 VPS11 -0.38 -5.24 -0.31 3.36e-7 Coronary artery disease; CESC cis rs7538876 0.935 rs11577822 chr1:17754608 T/G cg07965774 chr1:17746286 RCC2 0.31 5.05 0.3 8.15e-7 Basal cell carcinoma; CESC cis rs9902453 0.845 rs3115101 chr17:28041627 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.53 0.46 1.15e-15 Coffee consumption (cups per day); CESC cis rs9488822 0.676 rs12524249 chr6:116368813 G/A cg15226275 chr6:116381976 FRK 0.25 6.35 0.36 9.34e-10 Cholesterol, total;LDL cholesterol; CESC cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg20476274 chr7:133979776 SLC35B4 0.64 9.4 0.5 2.76e-18 Mean platelet volume; CESC cis rs933688 1.000 rs10474353 chr5:90732285 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 1.01 13.73 0.64 8.84e-33 Smoking behavior; CESC cis rs6733011 0.578 rs12712038 chr2:99497710 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.4 -5.03 -0.3 9.22e-7 Bipolar disorder; CESC cis rs35306767 0.903 rs12778891 chr10:950130 T/A cg25019033 chr10:957182 NA -0.58 -6.21 -0.36 2.08e-9 Eosinophil percentage of granulocytes; CESC cis rs4986172 0.690 rs11657325 chr17:43242694 C/T cg10701640 chr17:43249399 NA 0.39 6.39 0.37 7.39e-10 Height; CESC cis rs9888739 1.000 rs13338069 chr16:31299474 A/G cg15817542 chr16:31343056 ITGAM -0.44 -5.12 -0.3 5.84e-7 Systemic lupus erythematosus; CESC cis rs10838687 0.736 rs76832686 chr11:47247287 C/T cg25783544 chr11:47291846 MADD 0.58 6.65 0.38 1.63e-10 Proinsulin levels; CESC cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg20891558 chr2:74357851 NA 0.81 11.89 0.59 1.99e-26 Gestational age at birth (maternal effect); CESC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs10751667 0.666 rs4074233 chr11:977685 G/A cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.48e-7 Alzheimer's disease (late onset); CESC cis rs7659604 1.000 rs10005932 chr4:122664782 T/C cg19671926 chr4:122722719 EXOSC9 -0.44 -5.3 -0.31 2.49e-7 Type 2 diabetes; CESC cis rs6750795 0.641 rs10933375 chr2:232367296 A/T cg19187155 chr2:232395269 NMUR1 -0.44 -6.01 -0.35 6.26e-9 Height; CESC cis rs6460942 0.505 rs73055515 chr7:12328804 A/G cg20607287 chr7:12443886 VWDE -0.56 -5.71 -0.33 2.98e-8 Coronary artery disease; CESC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.46e-17 Gut microbiome composition (summer); CESC cis rs3733585 0.648 rs7378305 chr4:9954893 C/T cg00071950 chr4:10020882 SLC2A9 -0.69 -11.3 -0.57 2.01e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs992157 0.798 rs12053514 chr2:219167965 C/T cg00012203 chr2:219082015 ARPC2 -0.73 -9.49 -0.5 1.37e-18 Colorectal cancer; CESC cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg13147721 chr7:65941812 NA -0.88 -8.52 -0.46 1.19e-15 Diabetic kidney disease; CESC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.53 -0.54 7e-22 Alzheimer's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20269352 chr1:44483206 SLC6A9 0.4 6.21 0.36 1.99e-9 Gut microbiota (bacterial taxa); CESC cis rs1620921 0.505 rs9456586 chr6:161207643 G/A cg01280913 chr6:161186852 NA -0.38 -5.73 -0.33 2.67e-8 Lipoprotein (a) - cholesterol levels; CESC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg06212747 chr3:49208901 KLHDC8B 0.74 9.97 0.52 4.37e-20 Parkinson's disease; CESC cis rs4268898 0.662 rs72793967 chr2:24422902 C/T cg06627628 chr2:24431161 ITSN2 -1.03 -11.36 -0.57 1.26e-24 Asthma; CESC cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg17294928 chr15:75287854 SCAMP5 -0.74 -8.51 -0.46 1.35e-15 Blood trace element (Zn levels); CESC cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg23711669 chr6:146136114 FBXO30 -0.99 -15.26 -0.68 3.83e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg03538708 chr1:25844672 NA -0.42 -6.33 -0.36 1.04e-9 Erythrocyte sedimentation rate; CESC cis rs17253792 0.822 rs78922774 chr14:56115302 T/A cg24579896 chr14:56047964 C14orf33;KTN1 0.8 5.65 0.33 4.2e-8 Putamen volume; CESC cis rs7247513 0.759 rs8110545 chr19:12754898 C/T cg23899408 chr19:12877188 HOOK2 0.43 5.21 0.3 3.82e-7 Bipolar disorder; CESC cis rs861020 1.000 rs7555285 chr1:209970355 C/G cg05527609 chr1:210001259 C1orf107 -0.8 -9.49 -0.5 1.45e-18 Orofacial clefts; CESC cis rs11711311 1.000 rs3773682 chr3:113520576 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.59 7.86 0.44 9.41e-14 IgG glycosylation; CESC cis rs7927771 0.542 rs10769300 chr11:47865560 C/T cg18512352 chr11:47633146 NA 0.35 5.37 0.31 1.7e-7 Subjective well-being; CESC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg21251018 chr6:28226885 NKAPL 0.36 6.01 0.35 6.18e-9 Cardiac Troponin-T levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25187967 chr11:77024606 NA -0.69 -8.26 -0.45 6.96e-15 Gut microbiome composition (summer); CESC cis rs690037 0.780 rs690437 chr3:16380890 C/T cg23474789 chr3:16306055 DPH3;OXNAD1 -0.43 -5.87 -0.34 1.33e-8 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); CESC cis rs73001065 0.688 rs59148799 chr19:19484008 A/G cg03709012 chr19:19516395 GATAD2A 0.93 7.68 0.43 3.03e-13 LDL cholesterol; CESC cis rs4332037 0.950 rs11767515 chr7:1941051 C/T cg23422044 chr7:1970798 MAD1L1 -0.53 -5.33 -0.31 2.09e-7 Bipolar disorder; CESC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs2732480 0.500 rs11168468 chr12:48612465 C/T cg24011408 chr12:48396354 COL2A1 0.43 5.98 0.35 7.02e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg17724175 chr1:150552817 MCL1 0.4 6.13 0.35 3.25e-9 Melanoma; CESC cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg10691866 chr7:65817282 TPST1 0.31 5.37 0.31 1.75e-7 Aortic root size; CESC cis rs9902453 0.967 rs8072664 chr17:28333385 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.83 -0.43 1.15e-13 Coffee consumption (cups per day); CESC cis rs2070997 0.667 rs7851946 chr9:133719256 A/T cg11464064 chr9:133710261 ABL1 -0.68 -7.94 -0.44 5.93e-14 Response to amphetamines; CESC cis rs9837602 0.507 rs793448 chr3:99532949 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.63 -9.82 -0.52 1.35e-19 Breast cancer; CESC cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg23711669 chr6:146136114 FBXO30 0.97 14.97 0.68 4.06e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs763121 0.853 rs2267393 chr22:39101619 G/C cg06544989 chr22:39130855 UNC84B 0.51 9.58 0.51 7.49e-19 Menopause (age at onset); CESC cis rs611744 0.647 rs7015513 chr8:109262570 A/C cg21045802 chr8:109455806 TTC35 0.47 5.83 0.34 1.63e-8 Dupuytren's disease; CESC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg26314531 chr2:26401878 FAM59B -0.59 -6.67 -0.38 1.5e-10 Gut microbiome composition (summer); CESC trans rs10242455 0.702 rs55927283 chr7:99057191 G/C cg09045935 chr12:6379348 NA 0.89 7.65 0.43 3.65e-13 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15132647 chr1:52607948 ZFYVE9 0.59 6.53 0.37 3.26e-10 Gut microbiome composition (summer); CESC cis rs9894429 0.966 rs6565605 chr17:79589359 C/T cg13777783 chr17:79615861 NA -0.35 -5.82 -0.34 1.66e-8 Eye color traits; CESC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.57 7.57 0.42 6.21e-13 Total body bone mineral density; CESC cis rs1023500 0.505 rs134891 chr22:42675882 T/C cg15557168 chr22:42548783 NA -0.44 -6.85 -0.39 5.25e-11 Schizophrenia; CESC cis rs9326248 0.530 rs10750100 chr11:116917244 T/C cg01368799 chr11:117014884 PAFAH1B2 0.56 5.18 0.3 4.38e-7 Blood protein levels; CESC cis rs9309473 1.000 rs10207220 chr2:73785046 G/C cg20560298 chr2:73613845 ALMS1 -0.55 -7.22 -0.41 5.42e-12 Metabolite levels; CESC trans rs2099077 0.867 rs75781417 chr5:102795938 G/T cg07434438 chr16:72961899 ZFHX3 0.49 6.67 0.38 1.5e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs14057 0.792 rs78728410 chr1:6663031 G/C cg06778853 chr1:6672620 PHF13 -0.28 -5.2 -0.3 3.96e-7 Systolic blood pressure; CESC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs763014 0.966 rs15564 chr16:677854 G/T cg07343612 chr16:622815 PIGQ -0.55 -8.26 -0.45 6.8e-15 Height; CESC cis rs2749592 0.513 rs1208708 chr10:38085576 A/G cg25427524 chr10:38739819 LOC399744 -0.65 -9.81 -0.52 1.37e-19 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg20203395 chr5:56204925 C5orf35 0.4 5.23 0.31 3.39e-7 Initial pursuit acceleration; CESC cis rs796364 0.762 rs13030712 chr2:200973569 G/A cg23649088 chr2:200775458 C2orf69 0.56 6.68 0.38 1.43e-10 Schizophrenia; CESC cis rs9287719 0.967 rs10206225 chr2:10758657 A/G cg00105475 chr2:10696890 NA 0.37 5.38 0.31 1.67e-7 Prostate cancer; CESC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.64 0.38 1.77e-10 Bipolar disorder; CESC cis rs28374715 0.578 rs17730589 chr15:41600878 T/C cg18705301 chr15:41695430 NDUFAF1 -1.07 -15.33 -0.69 2.03e-38 Ulcerative colitis; CESC cis rs8141529 0.748 rs7287918 chr22:29281710 G/A cg02153584 chr22:29168773 CCDC117 0.59 7.62 0.42 4.62e-13 Lymphocyte counts; CESC cis rs3026101 0.671 rs2285746 chr17:5311742 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs501120 0.810 rs513391 chr10:44749708 A/C cg09554077 chr10:44749378 NA 0.49 6.61 0.38 2.11e-10 Coronary artery disease;Coronary heart disease; CESC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.71 -7.92 -0.44 6.62e-14 Gut microbiome composition (summer); CESC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg17376030 chr22:41985996 PMM1 -0.78 -8.24 -0.45 7.79e-15 Vitiligo; CESC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg08109568 chr15:31115862 NA -0.7 -9.33 -0.5 4.49e-18 Huntington's disease progression; CESC cis rs7116495 1.000 rs73539532 chr11:71815684 C/A cg10381502 chr11:71823885 C11orf51 0.66 5.35 0.31 1.93e-7 Severe influenza A (H1N1) infection; CESC cis rs2011503 0.882 rs10423874 chr19:19359500 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.53 5.58 0.32 6.04e-8 Bipolar disorder; CESC cis rs67311347 1.000 rs4246666 chr3:40407670 C/T cg01475735 chr3:40494733 NA -0.4 -5.08 -0.3 7.3e-7 Renal cell carcinoma; CESC cis rs6598955 0.950 rs6700455 chr1:26545864 T/C cg04990556 chr1:26633338 UBXN11 0.81 10.92 0.56 3.5e-23 Obesity-related traits; CESC cis rs10751667 1.000 rs6597972 chr11:928402 C/T cg06064525 chr11:970664 AP2A2 -0.41 -7.37 -0.41 2.18e-12 Alzheimer's disease (late onset); CESC cis rs854765 0.856 rs2955382 chr17:17947710 C/T cg16928487 chr17:17741425 SREBF1 0.51 8.67 0.47 4.53e-16 Total body bone mineral density; CESC cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs796364 0.715 rs77089299 chr2:201116853 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.77 -5.14 -0.3 5.37e-7 Schizophrenia; CESC cis rs116095464 0.558 rs7708182 chr5:234788 C/G cg22496380 chr5:211416 CCDC127 -0.75 -8.8 -0.48 1.82e-16 Breast cancer; CESC trans rs11168187 0.528 rs2214526 chr12:47942029 A/G cg11982293 chr2:175205387 NA 0.44 6.1 0.35 3.69e-9 Vertical cup-disc ratio; CESC trans rs4332037 0.539 rs55993248 chr7:2071132 A/G cg11693508 chr17:37793320 STARD3 0.62 6.17 0.35 2.52e-9 Bipolar disorder; CESC trans rs66573146 1.000 rs55672215 chr4:6970529 T/C cg07817883 chr1:32538562 TMEM39B 1.28 8.41 0.46 2.55e-15 Granulocyte percentage of myeloid white cells; CESC cis rs7631605 0.905 rs7611106 chr3:37017024 G/A cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.09 -0.3 6.91e-7 Cerebrospinal P-tau181p levels; CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg14893161 chr1:205819251 PM20D1 0.95 18.5 0.75 1.29e-49 Menarche (age at onset); CESC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg04944784 chr2:26401820 FAM59B -0.93 -10.74 -0.55 1.38e-22 Gut microbiome composition (summer); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg08854128 chr5:171881546 SH3PXD2B 0.43 6.05 0.35 4.84e-9 Breast cancer;Type 2 diabetes; CESC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.12 -0.63 1.24e-30 Developmental language disorder (linguistic errors); CESC cis rs2404602 0.692 rs36070630 chr15:76949259 T/C cg22467129 chr15:76604101 ETFA -0.36 -5.3 -0.31 2.43e-7 Blood metabolite levels; CESC cis rs6460942 1.000 rs75333414 chr7:12303829 T/A cg10578991 chr7:12443926 VWDE -0.49 -5.35 -0.31 1.87e-7 Coronary artery disease; CESC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg25838465 chr1:92012736 NA -0.64 -10.21 -0.53 7.26e-21 Breast cancer; CESC cis rs7089973 0.966 rs12775180 chr10:116639754 T/C cg25233709 chr10:116636983 FAM160B1 0.37 5.19 0.3 4.09e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1577917 1.000 rs12215037 chr6:86727631 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.32 -0.36 1.11e-9 Response to antipsychotic treatment; CESC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg21782813 chr7:2030301 MAD1L1 0.44 6.16 0.35 2.7e-9 Bipolar disorder and schizophrenia; CESC cis rs644799 1.000 rs474252 chr11:95619292 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.47 5.66 0.33 3.97e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9768139 0.935 rs7809076 chr7:158118438 C/T cg06219351 chr7:158114137 PTPRN2 0.44 6.87 0.39 4.53e-11 Calcium levels; CESC cis rs881375 0.702 rs3761847 chr9:123690239 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.43 6.25 0.36 1.64e-9 Rheumatoid arthritis; CESC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg21770322 chr7:97807741 LMTK2 0.55 8.25 0.45 7.24e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs6460942 0.915 rs17324858 chr7:12305792 G/T cg20607287 chr7:12443886 VWDE -0.42 -6.08 -0.35 4.12e-9 Coronary artery disease; CESC cis rs6493487 0.512 rs7175024 chr15:51257790 A/G cg02338191 chr15:51200825 AP4E1 0.63 5.85 0.34 1.46e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs3733585 0.604 rs73215003 chr4:10126317 C/G cg02734326 chr4:10020555 SLC2A9 -0.38 -5.3 -0.31 2.43e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7927592 0.913 rs11228262 chr11:68274907 G/T cg20283391 chr11:68216788 NA -0.63 -7.61 -0.42 4.78e-13 Total body bone mineral density; CESC cis rs7429990 0.965 rs6791834 chr3:48115088 C/A cg11946769 chr3:48343235 NME6 -0.45 -5.53 -0.32 7.61e-8 Educational attainment (years of education); CESC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg00166722 chr3:10149974 C3orf24 0.55 7.09 0.4 1.21e-11 Alzheimer's disease; CESC cis rs6424115 0.679 rs2294495 chr1:24075876 C/T cg15997130 chr1:24165203 NA -0.45 -5.47 -0.32 1.07e-7 Immature fraction of reticulocytes; CESC trans rs156299 0.798 rs156278 chr7:24202161 G/A cg05664523 chr2:677534 TMEM18 -0.46 -6.01 -0.35 6.09e-9 Vitamin D levels; CESC cis rs6088590 0.965 rs6087639 chr20:33443866 G/A cg06115741 chr20:33292138 TP53INP2 0.63 8.0 0.44 3.94e-14 Coronary artery disease; CESC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg23982607 chr1:1823379 GNB1 -0.77 -12.45 -0.61 2.6e-28 Body mass index; CESC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg22105103 chr4:187893119 NA 0.46 6.66 0.38 1.61e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7605827 0.930 rs7578126 chr2:15522772 C/T cg19274914 chr2:15703543 NA 0.33 5.83 0.34 1.65e-8 Educational attainment (years of education); CESC cis rs17092148 0.636 rs2295096 chr20:33464710 A/G cg24642439 chr20:33292090 TP53INP2 -0.5 -5.06 -0.3 7.9e-7 Neuroticism; CESC cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg05340658 chr4:99064831 C4orf37 0.81 12.3 0.6 8.1e-28 Colonoscopy-negative controls vs population controls; CESC cis rs72634258 0.786 rs9434993 chr1:8179744 G/C cg00042356 chr1:8021962 PARK7 0.5 5.4 0.31 1.47e-7 Inflammatory bowel disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00605358 chr12:89747739 DUSP6 -0.46 -6.63 -0.38 1.86e-10 Gambling; CESC cis rs709400 0.633 rs3783395 chr14:103895020 T/C cg12935359 chr14:103987150 CKB -0.5 -7.29 -0.41 3.62e-12 Body mass index; CESC cis rs6752107 0.936 rs1045100 chr2:234203597 T/C cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.41 6.14 0.35 2.93e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs796364 1.000 rs281762 chr2:200799201 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.83 8.38 0.46 3.17e-15 Schizophrenia; CESC cis rs2425143 1.000 rs11699044 chr20:34312713 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.61 -5.89 -0.34 1.17e-8 Blood protein levels; CESC cis rs963731 0.649 rs2888585 chr2:39246683 C/T cg04010122 chr2:39346883 SOS1 -0.72 -5.37 -0.31 1.7e-7 Corticobasal degeneration; CESC cis rs9818941 0.824 rs60410659 chr3:157811198 A/T cg08654915 chr3:157813417 NA 0.44 7.29 0.41 3.5e-12 Height; CESC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg10578991 chr7:12443926 VWDE -0.45 -5.09 -0.3 6.83e-7 Coronary artery disease; CESC cis rs225245 0.817 rs225290 chr17:33927904 C/G cg05299278 chr17:33885742 SLFN14 0.38 5.48 0.32 1.01e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg01341218 chr17:43662625 NA 0.86 9.97 0.52 4.49e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg24562669 chr7:97807699 LMTK2 0.52 7.65 0.43 3.64e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs9916302 0.904 rs11867312 chr17:37597748 C/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 4.03e-10 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07155211 chr1:23695625 C1orf213;ZNF436 0.57 6.38 0.36 7.8e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16169620 chr1:155827015 GON4L 0.6 6.61 0.38 2.15e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.717 rs1800358 chr16:89809319 T/C cg04013166 chr16:89971882 TCF25 0.72 7.87 0.44 9.3e-14 Skin colour saturation; CESC cis rs6460942 0.556 rs2287067 chr7:12370533 T/C cg02935154 chr7:12443704 VWDE -0.4 -5.34 -0.31 2.04e-7 Coronary artery disease; CESC cis rs11252926 0.574 rs4881254 chr10:453567 C/T cg18196295 chr10:418757 DIP2C 0.54 7.45 0.42 1.32e-12 Psychosis in Alzheimer's disease; CESC cis rs919433 0.684 rs55775495 chr2:198245965 C/T cg03934865 chr2:198174659 NA 0.37 5.35 0.31 1.89e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg04772025 chr11:68637568 NA 0.57 6.63 0.38 1.87e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg11366901 chr6:160182831 ACAT2 0.77 9.23 0.49 8.69e-18 Age-related macular degeneration (geographic atrophy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04579263 chr14:91525979 RPS6KA5 -0.49 -6.25 -0.36 1.61e-9 Gut microbiome composition (summer); CESC cis rs7071206 0.947 rs10509391 chr10:79422369 G/A cg23888215 chr10:79422304 NA -0.52 -5.53 -0.32 7.8e-8 Bone mineral density; CESC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.56 0.58 2.62e-25 Platelet count; CESC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg11764359 chr7:65958608 NA -0.81 -9.53 -0.51 1.05e-18 Aortic root size; CESC cis rs1448094 0.621 rs7133309 chr12:86284078 T/C cg02569458 chr12:86230093 RASSF9 0.41 6.12 0.35 3.27e-9 Major depressive disorder; CESC cis rs4664308 0.967 rs34248629 chr2:160902497 C/T cg03641300 chr2:160917029 PLA2R1 -0.67 -9.8 -0.52 1.55e-19 Idiopathic membranous nephropathy; CESC cis rs11229555 1.000 rs10896795 chr11:58366561 A/G cg15696309 chr11:58395628 NA -0.44 -5.64 -0.33 4.46e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs9916302 0.706 rs1874226 chr17:37729031 C/T cg00129232 chr17:37814104 STARD3 0.59 6.12 0.35 3.3e-9 Glomerular filtration rate (creatinine); CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg16145915 chr7:1198662 ZFAND2A -0.53 -6.66 -0.38 1.61e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8014204 0.762 rs2359237 chr14:75245002 G/A cg08847533 chr14:75593920 NEK9 0.41 5.27 0.31 2.87e-7 Caffeine consumption; CESC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg26335602 chr6:28129616 ZNF389 0.48 6.54 0.37 3.07e-10 Depression; CESC trans rs11098499 0.739 rs9996382 chr4:120151012 C/T cg25214090 chr10:38739885 LOC399744 0.54 7.3 0.41 3.27e-12 Corneal astigmatism; CESC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg22920501 chr2:26401640 FAM59B 0.92 10.12 0.53 1.47e-20 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs9403755 chr6:146231470 C/A cg05347473 chr6:146136440 FBXO30 -0.55 -7.05 -0.4 1.57e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs228437 1.000 rs9376050 chr6:134910136 A/G cg24504307 chr6:134963096 NA 0.61 6.4 0.37 6.87e-10 Melanoma; CESC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg11494091 chr17:61959527 GH2 0.73 12.48 0.61 2.02e-28 Prudent dietary pattern; CESC cis rs60154123 0.614 rs646512 chr1:210453938 C/T cg21951975 chr1:209979733 IRF6 -0.42 -6.07 -0.35 4.4e-9 Coronary artery disease; CESC cis rs9443189 0.813 rs2842556 chr6:76447204 T/C cg01950844 chr6:76311363 SENP6 -0.59 -6.53 -0.37 3.32e-10 Prostate cancer; CESC cis rs6964587 1.000 rs7785095 chr7:91640773 A/T cg17063962 chr7:91808500 NA -0.56 -7.76 -0.43 1.9e-13 Breast cancer; CESC cis rs1322639 0.614 rs9364361 chr6:169580499 C/T cg04662567 chr6:169592167 NA -0.56 -5.95 -0.34 8.47e-9 Pulse pressure; CESC cis rs17023223 0.537 rs10923756 chr1:119674648 A/T cg05756136 chr1:119680316 WARS2 -0.47 -5.71 -0.33 3.1e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs11122272 0.766 rs2808608 chr1:231543175 A/G cg06096015 chr1:231504339 EGLN1 0.41 5.71 0.33 3e-8 Hemoglobin concentration; CESC cis rs6032067 1.000 rs6032052 chr20:43829883 C/A cg11264863 chr20:43835661 SEMG1 0.48 5.29 0.31 2.56e-7 Blood protein levels; CESC cis rs1712517 0.503 rs72846198 chr10:105098024 G/A cg04362960 chr10:104952993 NT5C2 -0.49 -5.85 -0.34 1.45e-8 Migraine; CESC cis rs2281845 0.965 rs7516023 chr1:201085521 C/T cg17810781 chr1:201082982 CACNA1S 0.37 5.1 0.3 6.48e-7 Permanent tooth development; CESC cis rs2070997 0.607 rs4602941 chr9:133663776 C/T cg11464064 chr9:133710261 ABL1 0.56 6.44 0.37 5.64e-10 Response to amphetamines; CESC cis rs9640161 0.711 rs60268791 chr7:150023800 G/T cg21361702 chr7:150065534 REPIN1 0.45 5.29 0.31 2.6e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs926938 0.563 rs360645 chr1:115427218 A/G cg12756093 chr1:115239321 AMPD1 0.5 7.34 0.41 2.59e-12 Autism; CESC cis rs60871478 1.000 rs62432250 chr7:801792 C/G cg05535760 chr7:792225 HEATR2 0.85 10.63 0.55 3.18e-22 Cerebrospinal P-tau181p levels; CESC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs798766 0.723 rs3134865 chr4:1723279 T/C cg07041428 chr4:1763019 NA -0.39 -5.56 -0.32 6.66e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs73206853 0.764 rs6606685 chr12:110881986 C/G cg12870014 chr12:110450643 ANKRD13A 0.65 5.85 0.34 1.45e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs7618501 1.000 rs57648519 chr3:49813169 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.5 0.46 1.41e-15 Intelligence (multi-trait analysis); CESC trans rs3808502 0.549 rs4841564 chr8:11425809 T/G cg15556689 chr8:8085844 FLJ10661 -0.58 -6.82 -0.39 6.24e-11 Neuroticism; CESC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg27266027 chr21:40555129 PSMG1 -0.43 -5.04 -0.3 8.76e-7 Cognitive function; CESC cis rs2635047 0.638 rs2668784 chr18:44711391 A/G cg24371990 chr18:44770781 NA 0.32 5.15 0.3 5.03e-7 Educational attainment; CESC cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg12292205 chr6:26970375 C6orf41 -0.53 -5.84 -0.34 1.53e-8 Intelligence (multi-trait analysis); CESC cis rs7264396 0.790 rs6058294 chr20:34259396 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.83 -0.59 3.29e-26 Total cholesterol levels; CESC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg07648498 chr16:89883185 FANCA 0.47 5.88 0.34 1.24e-8 Vitiligo; CESC cis rs6693567 0.545 rs1694386 chr1:150377965 C/G cg09579323 chr1:150459698 TARS2 0.47 5.88 0.34 1.23e-8 Migraine; CESC cis rs3820068 0.581 rs1547031 chr1:15918960 G/A cg16988262 chr1:15930761 NA 0.33 5.33 0.31 2.14e-7 Systolic blood pressure; CESC cis rs244293 0.672 rs9901526 chr17:53012379 G/T cg19360675 chr17:53046073 COX11;STXBP4 -0.5 -6.64 -0.38 1.74e-10 Menarche (age at onset); CESC cis rs698833 0.892 rs786618 chr2:44593929 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.97 0.34 7.41e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs12579753 0.872 rs11519752 chr12:82207300 A/G cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs2243480 1.000 rs781150 chr7:65480973 C/T cg25894440 chr7:65020034 NA -0.68 -5.84 -0.34 1.51e-8 Diabetic kidney disease; CESC cis rs818427 0.896 rs712663 chr5:112223594 T/C cg07820702 chr5:112228657 REEP5 -0.47 -6.16 -0.35 2.67e-9 Total body bone mineral density; CESC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.52 0.37 3.54e-10 Prudent dietary pattern; CESC cis rs2066819 1.000 rs79750959 chr12:56702012 C/A cg26804944 chr12:56660921 COQ10A -0.85 -5.14 -0.3 5.39e-7 Psoriasis vulgaris; CESC cis rs7216064 1.000 rs11079707 chr17:65835617 A/G cg12091567 chr17:66097778 LOC651250 0.79 8.64 0.47 5.53e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs1814175 0.645 rs7103554 chr11:50027612 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -18.53 -0.75 9.55e-50 Height; CESC cis rs3862435 0.572 rs2589969 chr15:90908051 T/C cg22089800 chr15:90895588 ZNF774 0.49 5.33 0.31 2.13e-7 Response to exercise (triglyceride level interaction); CESC trans rs1814175 0.645 rs11040703 chr11:50024961 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -6.13 -0.35 3.1e-9 Height; CESC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.5 -6.71 -0.38 1.21e-10 Menarche (age at onset); CESC cis rs10504229 0.679 rs12679920 chr8:58051710 G/T cg22535103 chr8:58192502 C8orf71 -0.68 -7.38 -0.41 2.03e-12 Developmental language disorder (linguistic errors); CESC cis rs7223966 0.691 rs9893518 chr17:62006997 A/G cg11494091 chr17:61959527 GH2 0.41 5.5 0.32 8.88e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2235544 0.565 rs633697 chr1:54468760 A/G cg25741118 chr1:54482237 LDLRAD1 0.24 5.77 0.33 2.2e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs66573146 0.656 rs66905212 chr4:6949508 G/C cg00086871 chr4:6988644 TBC1D14 0.97 5.88 0.34 1.23e-8 Granulocyte percentage of myeloid white cells; CESC cis rs9443645 0.509 rs12176511 chr6:79565721 G/A cg05283184 chr6:79620031 NA 0.41 6.04 0.35 5.19e-9 Intelligence (multi-trait analysis); CESC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg24675658 chr1:53192096 ZYG11B 0.64 8.84 0.48 1.36e-16 Monocyte count; CESC cis rs4253772 0.550 rs9615949 chr22:46722531 C/T cg24881330 chr22:46731750 TRMU 0.77 6.28 0.36 1.36e-9 LDL cholesterol;Cholesterol, total; CESC cis rs2408955 0.521 rs11168437 chr12:48566156 C/T cg04545296 chr12:48745243 ZNF641 0.36 6.07 0.35 4.32e-9 Glycated hemoglobin levels; CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg07167872 chr1:205819463 PM20D1 -0.63 -10.55 -0.54 5.77e-22 Monocyte percentage of white cells; CESC cis rs7927771 0.524 rs11039419 chr11:47851354 C/T cg20307385 chr11:47447363 PSMC3 0.62 8.62 0.47 6.13e-16 Subjective well-being; CESC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg05564831 chr3:52568323 NT5DC2 0.46 7.32 0.41 3.01e-12 Electroencephalogram traits; CESC trans rs3942852 0.568 rs2904315 chr11:48109948 C/T cg15704280 chr7:45808275 SEPT13 0.74 9.7 0.51 3.07e-19 Acute lymphoblastic leukemia (childhood); CESC trans rs1814175 0.645 rs28478790 chr11:50054322 C/A cg15704280 chr7:45808275 SEPT13 -1.0 -18.7 -0.75 2.39e-50 Height; CESC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg12718519 chr1:2058417 PRKCZ -0.26 -5.55 -0.32 6.98e-8 Height; CESC cis rs2742234 0.955 rs2075910 chr10:43614230 G/A cg15436174 chr10:43711423 RASGEF1A -0.4 -5.11 -0.3 6.04e-7 Hirschsprung disease; CESC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg22143856 chr6:28129313 ZNF389 0.52 6.51 0.37 3.67e-10 Depression; CESC cis rs7264396 0.790 rs3746410 chr20:34190870 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -7.5 -0.42 9.55e-13 Total cholesterol levels; CESC cis rs6570726 0.967 rs365515 chr6:145802833 C/T cg05347473 chr6:146136440 FBXO30 -0.42 -5.67 -0.33 3.78e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.05 0.59 5.93e-27 Alzheimer's disease; CESC cis rs7103648 0.742 rs34937994 chr11:47389638 C/T cg03711944 chr11:47377212 SPI1 -0.35 -5.44 -0.32 1.22e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs35110281 0.837 rs2838341 chr21:45076443 A/G cg21573476 chr21:45109991 RRP1B -0.48 -6.81 -0.39 6.56e-11 Mean corpuscular volume; CESC cis rs11122272 0.735 rs2474623 chr1:231513993 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02737517 chr20:62729726 OPRL1 -0.5 -6.06 -0.35 4.73e-9 Gut microbiome composition (summer); CESC cis rs6432018 0.927 rs11674769 chr2:9734278 T/C cg23886495 chr2:9695866 ADAM17 0.43 5.08 0.3 7.2e-7 Heart rate variability traits; CESC cis rs9911578 1.000 rs1267545 chr17:56646909 A/G cg12560992 chr17:57184187 TRIM37 0.92 15.27 0.68 3.42e-38 Intelligence (multi-trait analysis); CESC cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg00080972 chr5:178986291 RUFY1 0.39 5.69 0.33 3.32e-8 Lung cancer; CESC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg19592336 chr6:28129416 ZNF389 0.54 6.94 0.39 3e-11 Parkinson's disease; CESC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg00310523 chr12:86230176 RASSF9 0.36 5.71 0.33 3.02e-8 Major depressive disorder; CESC cis rs2073300 0.536 rs6137947 chr20:23414630 C/A cg12062639 chr20:23401060 NAPB 1.04 8.1 0.45 1.97e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg11764359 chr7:65958608 NA 0.82 9.71 0.51 2.93e-19 Aortic root size; CESC trans rs11098499 0.619 rs28502463 chr4:120257023 T/C cg25214090 chr10:38739885 LOC399744 0.64 9.08 0.49 2.59e-17 Corneal astigmatism; CESC cis rs4654899 1.000 rs2271115 chr1:21295864 C/T cg05370193 chr1:21551575 ECE1 0.39 5.9 0.34 1.12e-8 Superior frontal gyrus grey matter volume; CESC cis rs470119 0.902 rs131808 chr22:50963357 G/C cg12969734 chr22:50962224 SCO2 0.4 6.13 0.35 3.24e-9 Mean corpuscular hemoglobin; CESC cis rs6456156 0.586 rs12203510 chr6:167473006 C/T cg07741184 chr6:167504864 NA 0.35 5.84 0.34 1.49e-8 Primary biliary cholangitis; CESC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg00409905 chr10:38381863 ZNF37A -0.47 -6.33 -0.36 1.04e-9 Extrinsic epigenetic age acceleration; CESC cis rs7799006 0.722 rs33981648 chr7:2288669 T/C cg08027265 chr7:2291960 NA -0.57 -9.68 -0.51 3.53e-19 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs561341 0.505 rs548298 chr17:30297494 C/A cg20587970 chr11:113659929 NA -1.12 -14.24 -0.66 1.49e-34 Hip circumference adjusted for BMI; CESC cis rs68170813 0.523 rs10253172 chr7:106786474 C/T cg02696742 chr7:106810147 HBP1 0.56 5.3 0.31 2.45e-7 Coronary artery disease; CESC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg07701084 chr6:150067640 NUP43 0.46 6.64 0.38 1.81e-10 Lung cancer; CESC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.39 0.31 1.54e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3008870 0.959 rs3008852 chr1:67383416 G/A cg02640540 chr1:67518911 SLC35D1 0.47 5.11 0.3 6.28e-7 Lymphocyte percentage of white cells; CESC cis rs14403 1.000 rs111667565 chr1:243669012 T/C cg21452805 chr1:244014465 NA 0.51 5.8 0.34 1.92e-8 Schizophrenia; CESC cis rs9911578 0.933 rs2531726 chr17:56522533 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.38 -5.1 -0.3 6.41e-7 Intelligence (multi-trait analysis); CESC cis rs412050 0.895 rs240065 chr22:22296119 C/T cg17089214 chr22:22089827 YPEL1 0.73 6.94 0.39 2.93e-11 Attention deficit hyperactivity disorder; CESC cis rs72945132 0.882 rs61177215 chr11:70129534 G/A cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs6430585 0.583 rs3769012 chr2:136556480 C/T cg07169764 chr2:136633963 MCM6 1.32 19.18 0.76 5.29e-52 Corneal structure; CESC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg07153921 chr17:41440717 NA -0.38 -5.04 -0.3 8.65e-7 Menopause (age at onset); CESC cis rs1879734 0.731 rs7555617 chr1:54158155 A/C cg23596471 chr1:54105337 GLIS1 0.35 5.57 0.32 6.32e-8 Mitral valve prolapse; CESC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg20151795 chr6:28129481 ZNF389 0.44 5.55 0.32 6.85e-8 Depression; CESC cis rs7605827 0.930 rs2380657 chr2:15678482 T/C cg19274914 chr2:15703543 NA 0.36 6.39 0.37 7.29e-10 Educational attainment (years of education); CESC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17237111 chr4:114682438 CAMK2D -0.5 -6.57 -0.37 2.7e-10 Gut microbiota (bacterial taxa); CESC cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg24112000 chr20:60950667 NA -0.45 -5.3 -0.31 2.39e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs17376456 0.877 rs114256265 chr5:93473130 T/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.33 0.31 2.11e-7 Diabetic retinopathy; CESC cis rs9487051 0.714 rs7774377 chr6:109602443 G/A cg21918786 chr6:109611834 NA -0.38 -5.68 -0.33 3.54e-8 Reticulocyte fraction of red cells; CESC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg10253484 chr15:75165896 SCAMP2 -0.51 -6.94 -0.39 2.93e-11 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19458608 chr3:129830607 LOC729375 -0.62 -6.97 -0.39 2.5e-11 Gut microbiome composition (summer); CESC cis rs7124681 0.584 rs10769285 chr11:47709212 C/T cg18512352 chr11:47633146 NA 0.35 5.39 0.31 1.53e-7 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs7809950 1.000 rs2237672 chr7:107131563 A/C cg23024343 chr7:107201750 COG5 -0.42 -5.86 -0.34 1.37e-8 Coronary artery disease; CESC cis rs2228479 0.850 rs11640209 chr16:89807828 C/A cg06558623 chr16:89946397 TCF25 1.15 9.22 0.49 9.66e-18 Skin colour saturation; CESC cis rs11711311 1.000 rs9811746 chr3:113515060 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.69 9.46 0.5 1.74e-18 IgG glycosylation; CESC cis rs4141404 0.740 rs9609301 chr22:31895940 C/T cg00478049 chr22:31556069 RNF185 -0.44 -5.12 -0.3 5.86e-7 Paclitaxel-induced neuropathy; CESC cis rs1153858 1.000 rs2066090 chr15:45650018 T/C cg14582100 chr15:45693742 SPATA5L1 0.43 6.15 0.35 2.82e-9 Homoarginine levels; CESC cis rs17376456 0.825 rs12716454 chr5:93272279 A/C cg25358565 chr5:93447407 FAM172A 1.16 10.12 0.53 1.48e-20 Diabetic retinopathy; CESC cis rs9611565 0.649 rs202625 chr22:41827082 G/A cg17376030 chr22:41985996 PMM1 -0.76 -8.1 -0.45 2.03e-14 Vitiligo; CESC cis rs826838 0.872 rs826878 chr12:39088837 A/T cg26384229 chr12:38710491 ALG10B -0.6 -9.5 -0.5 1.28e-18 Heart rate; CESC cis rs929596 1.000 rs929596 chr2:234674476 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.64 -7.86 -0.43 9.75e-14 Total bilirubin levels in HIV-1 infection; CESC cis rs1023500 0.573 rs2269524 chr22:42475703 T/G cg15557168 chr22:42548783 NA 0.44 6.19 0.36 2.31e-9 Schizophrenia; CESC cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg13722127 chr7:150037890 RARRES2 0.35 5.03 0.3 9.21e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs2859741 0.967 rs575939 chr1:37513854 T/C cg09363841 chr1:37513479 NA -0.7 -11.57 -0.58 2.51e-25 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs881375 0.654 rs10760126 chr9:123662618 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.78 0.38 7.79e-11 Rheumatoid arthritis; CESC trans rs10776614 0.799 rs7088010 chr10:49767246 C/T cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg17372223 chr3:52568218 NT5DC2 0.4 5.94 0.34 8.99e-9 Electroencephalogram traits; CESC cis rs12130219 0.500 rs4845743 chr1:152184149 A/G cg17718321 chr1:152188247 HRNR -0.51 -8.49 -0.46 1.47e-15 Inflammatory skin disease; CESC cis rs60154123 0.505 rs77990373 chr1:210041111 T/C cg21951975 chr1:209979733 IRF6 0.58 6.23 0.36 1.85e-9 Coronary artery disease; CESC cis rs916888 0.821 rs70602 chr17:44859715 T/C cg01570182 chr17:44337453 NA -0.87 -10.41 -0.54 1.71e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg10556349 chr10:835070 NA -0.53 -5.44 -0.32 1.19e-7 Eosinophil percentage of granulocytes; CESC cis rs826838 0.967 rs11169142 chr12:39085773 A/T cg13010199 chr12:38710504 ALG10B -0.41 -5.63 -0.33 4.66e-8 Heart rate; CESC cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg02873098 chr16:4524103 NMRAL1;HMOX2 0.36 5.17 0.3 4.61e-7 Schizophrenia; CESC cis rs1775715 0.707 rs2808073 chr10:32179275 A/G cg18675610 chr10:32216311 ARHGAP12 0.35 5.33 0.31 2.07e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9911578 0.835 rs9889419 chr17:56473259 C/T cg05425664 chr17:57184151 TRIM37 -0.44 -6.24 -0.36 1.69e-9 Intelligence (multi-trait analysis); CESC cis rs2637266 0.653 rs846590 chr10:78491609 T/C cg18941641 chr10:78392320 NA 0.39 7.59 0.42 5.61e-13 Pulmonary function; CESC cis rs6089584 1.000 rs6089584 chr20:60564086 G/C cg13770153 chr20:60521292 NA -0.45 -5.95 -0.34 8.68e-9 Body mass index; CESC cis rs2046867 0.818 rs62249866 chr3:72878632 T/C cg25664220 chr3:72788482 NA -0.46 -6.44 -0.37 5.67e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs1843834 0.898 rs2015099 chr2:225519915 T/C cg22455342 chr2:225449267 CUL3 0.53 6.66 0.38 1.55e-10 IgE levels in asthmatics (D.p. specific); CESC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg22535103 chr8:58192502 C8orf71 -0.9 -9.02 -0.48 4e-17 Developmental language disorder (linguistic errors); CESC cis rs6831352 0.877 rs28987101 chr4:100049253 T/G cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg13393036 chr8:95962371 TP53INP1 -0.52 -11.41 -0.57 8.68e-25 Type 2 diabetes; CESC cis rs138880 0.505 rs56248708 chr22:50306969 G/A cg02269571 chr22:50332266 NA -0.67 -6.57 -0.37 2.6200000000000003e-10 Schizophrenia; CESC cis rs11711311 1.000 rs12631232 chr3:113497386 C/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.66 8.94 0.48 6.7e-17 IgG glycosylation; CESC cis rs11871801 1.000 rs72823064 chr17:40569974 T/C cg21433558 chr17:40837037 CNTNAP1 0.46 5.12 0.3 5.77e-7 Crohn's disease; CESC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg18016565 chr1:150552671 MCL1 0.33 5.11 0.3 6.22e-7 Tonsillectomy; CESC cis rs7762018 0.941 rs4716387 chr6:170136777 G/C cg13891659 chr6:170190454 C6orf122;C6orf208 0.61 6.19 0.36 2.33e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6665290 0.904 rs11578103 chr1:227189642 C/A cg10327440 chr1:227177885 CDC42BPA -1.22 -32.82 -0.9 2.35e-95 Myeloid white cell count; CESC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.08 -13.26 -0.63 4e-31 Gut microbiome composition (summer); CESC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg02551604 chr5:131831745 NA 0.38 5.35 0.31 1.9e-7 Asthma (sex interaction); CESC cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg02079420 chr8:82753780 SNX16 0.52 7.8 0.43 1.47e-13 Diastolic blood pressure; CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg12262378 chr17:6899522 ALOX12 0.39 6.69 0.38 1.35e-10 Tonsillectomy; CESC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg01416388 chr22:39784598 NA -0.58 -7.42 -0.41 1.58e-12 Intelligence (multi-trait analysis); CESC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.31 0.31 2.3e-7 Menopause (age at onset); CESC cis rs977987 0.800 rs3784935 chr16:75336430 T/G cg03315344 chr16:75512273 CHST6 0.39 5.48 0.32 1.01e-7 Dupuytren's disease; CESC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg15857475 chr8:145742913 RECQL4;LRRC14 -0.55 -7.91 -0.44 7.03e-14 Age at first birth; CESC cis rs4523957 0.620 rs8064309 chr17:2059961 T/C cg16513277 chr17:2031491 SMG6 -0.72 -10.2 -0.53 8.12e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs12476592 0.602 rs262533 chr2:63906048 C/G cg17519650 chr2:63277830 OTX1 -0.46 -5.11 -0.3 6.22e-7 Childhood ear infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14989522 chr19:58874386 ZNF497 -0.49 -6.65 -0.38 1.68e-10 Fibrinogen levels; CESC cis rs11792861 0.890 rs57387569 chr9:111920392 T/C cg05043794 chr9:111880884 C9orf5 -0.43 -6.8 -0.39 6.77e-11 Menarche (age at onset); CESC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg04944784 chr2:26401820 FAM59B -0.67 -7.75 -0.43 2e-13 Gut microbiome composition (summer); CESC cis rs17401966 1.000 rs1536263 chr1:10378914 T/C cg15208524 chr1:10270712 KIF1B 0.46 5.71 0.33 3.08e-8 Hepatocellular carcinoma; CESC trans rs4942242 0.663 rs7985489 chr13:44206148 T/C cg19169023 chr15:41853346 TYRO3 0.56 7.12 0.4 1.03e-11 Response to tocilizumab in rheumatoid arthritis; CESC trans rs10808739 0.588 rs10112945 chr8:65677331 C/A cg19896198 chr1:12123262 TNFRSF8 0.36 6.02 0.35 5.91e-9 HIV-1 susceptibility; CESC cis rs77956314 0.515 rs4767490 chr12:117435016 A/G cg16111737 chr12:117408163 FBXW8 -0.43 -5.11 -0.3 6.22e-7 Subcortical brain region volumes;Hippocampal volume; CESC cis rs7937682 0.587 rs571594 chr11:111359334 A/G cg09085632 chr11:111637200 PPP2R1B 0.6 7.82 0.43 1.27e-13 Primary sclerosing cholangitis; CESC cis rs7680126 0.596 rs4637402 chr4:10045430 C/T cg00071950 chr4:10020882 SLC2A9 0.66 7.66 0.43 3.5e-13 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs11098499 0.863 rs11098532 chr4:120490726 C/A cg24375607 chr4:120327624 NA 0.46 5.58 0.32 5.85e-8 Corneal astigmatism; CESC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg19622623 chr12:86230825 RASSF9 -0.46 -5.95 -0.34 8.4e-9 Major depressive disorder; CESC cis rs1707322 1.000 rs12097799 chr1:46459886 C/A cg05343316 chr1:45956843 TESK2 0.45 5.54 0.32 7.24e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10685336 chr3:149688848 PFN2 0.5 6.21 0.36 2.08e-9 Gut microbiome composition (summer); CESC cis rs6800768 0.633 rs826374 chr3:24163921 A/C cg10674438 chr3:24145617 LOC152024 -0.43 -6.34 -0.36 9.96e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9902453 0.765 rs2467334 chr17:28135508 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25393494 chr17:17109936 PLD6 0.35 5.99 0.35 6.69e-9 Fibrinogen levels; CESC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.47 5.62 0.33 4.81e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6433857 0.594 rs1406257 chr2:181521345 A/G cg23363182 chr2:181467187 NA -0.46 -6.24 -0.36 1.69e-9 Body mass index; CESC trans rs208520 0.560 rs2351880 chr6:66863707 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -13.07 -0.63 1.82e-30 Exhaled nitric oxide output; CESC cis rs9303542 0.559 rs12602539 chr17:46617459 T/A cg04904318 chr17:46607828 HOXB1 -0.58 -5.67 -0.33 3.64e-8 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs6570726 0.935 rs1883406 chr6:145823205 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6545883 0.965 rs12713439 chr2:61752154 G/A cg15711740 chr2:61764176 XPO1 -0.44 -5.38 -0.31 1.68e-7 Tuberculosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01923549 chr6:41774024 USP49 0.45 6.07 0.35 4.37e-9 Fibrinogen levels; CESC cis rs113835537 0.877 rs57127845 chr11:66318325 C/T cg22134325 chr11:66188745 NPAS4 0.52 5.94 0.34 9.15e-9 Airway imaging phenotypes; CESC cis rs9902453 0.967 rs60176674 chr17:28479854 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 8.09 0.44 2.2e-14 Coffee consumption (cups per day); CESC cis rs4704187 0.687 rs6885887 chr5:74497842 A/C cg03227963 chr5:74354835 NA 0.29 5.24 0.31 3.29e-7 Response to amphetamines; CESC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.42 -0.41 1.59e-12 Total body bone mineral density; CESC cis rs6732160 0.706 rs1430347 chr2:73367059 G/A cg01422370 chr2:73384389 NA 0.39 6.6 0.38 2.28e-10 Intelligence (multi-trait analysis); CESC cis rs4563143 0.514 rs73029079 chr19:29294903 A/G cg04546413 chr19:29218101 NA 0.49 6.05 0.35 4.79e-9 Methadone dose in opioid dependence; CESC cis rs637571 0.544 rs617791 chr11:65702523 C/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.59 7.66 0.43 3.48e-13 Eosinophil percentage of white cells; CESC cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.48 0.46 1.55e-15 Colonoscopy-negative controls vs population controls; CESC cis rs17539620 0.624 rs62432737 chr6:154834772 G/A cg20019720 chr6:154832845 CNKSR3 0.47 6.24 0.36 1.74e-9 Lipoprotein (a) levels; CESC trans rs60843830 1.000 rs17713729 chr2:249092 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 8.09 0.45 2.18e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs763121 0.853 rs4821808 chr22:39065739 A/G cg06544989 chr22:39130855 UNC84B 0.49 8.38 0.46 3.04e-15 Menopause (age at onset); CESC cis rs3105593 1.000 rs4775893 chr15:50898695 A/T cg08437265 chr15:50716283 USP8 0.42 5.55 0.32 7.01e-8 QT interval; CESC cis rs1008375 0.863 rs10003291 chr4:17600728 A/C cg02297831 chr4:17616191 MED28 0.58 6.99 0.39 2.2e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg23711669 chr6:146136114 FBXO30 -1.0 -15.54 -0.69 3.89e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg18404041 chr3:52824283 ITIH1 -0.37 -6.46 -0.37 4.87e-10 Electroencephalogram traits; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg26687565 chr4:141072046 MAML3 -0.47 -6.26 -0.36 1.53e-9 Thyroid stimulating hormone; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18543035 chr10:8374526 NA -0.4 -6.13 -0.35 3.18e-9 Gambling; CESC cis rs7520050 0.966 rs11211234 chr1:46438787 C/A cg03146154 chr1:46216737 IPP -0.47 -6.03 -0.35 5.46e-9 Red blood cell count;Reticulocyte count; CESC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.97 -0.34 7.54e-9 Parkinson's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16265552 chr3:113667068 ZDHHC23 0.51 6.72 0.38 1.11e-10 Gut microbiota (bacterial taxa); CESC cis rs17376456 0.877 rs17316137 chr5:93456577 C/T cg25358565 chr5:93447407 FAM172A 1.12 11.29 0.57 2.13e-24 Diabetic retinopathy; CESC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg26335602 chr6:28129616 ZNF389 0.52 6.84 0.39 5.58e-11 Depression; CESC cis rs2228479 0.850 rs9282681 chr16:89805914 T/C cg14709524 chr16:89940631 TCF25 0.87 6.45 0.37 5.39e-10 Skin colour saturation; CESC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs34779708 0.966 rs10827492 chr10:35429825 A/G cg03585969 chr10:35415529 CREM -0.73 -9.66 -0.51 4.03e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs6486730 0.508 rs7133440 chr12:129269244 A/C cg09035930 chr12:129282057 SLC15A4 -0.41 -5.25 -0.31 3.14e-7 Systemic lupus erythematosus; CESC cis rs2204008 0.538 rs61931093 chr12:38242911 C/T cg26384229 chr12:38710491 ALG10B -0.46 -5.98 -0.34 7.11e-9 Bladder cancer; CESC cis rs9393777 0.623 rs56296968 chr6:26474571 C/T cg14345882 chr6:26364793 BTN3A2 0.43 5.35 0.31 1.95e-7 Intelligence (multi-trait analysis); CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg16145915 chr7:1198662 ZFAND2A -0.71 -11.32 -0.57 1.65e-24 Longevity;Endometriosis; CESC cis rs11122272 0.668 rs1538664 chr1:231555295 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -6.64 -0.38 1.8e-10 Hemoglobin concentration; CESC cis rs12368653 0.591 rs1038914 chr12:58011066 G/A cg00700412 chr12:58011837 NA -0.46 -7.26 -0.41 4.29e-12 Multiple sclerosis; CESC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg04944784 chr2:26401820 FAM59B -0.78 -8.86 -0.48 1.18e-16 Gut microbiome composition (summer); CESC cis rs2013441 0.670 rs35317166 chr17:19959820 T/A cg12073167 chr17:19770448 ULK2 -0.43 -5.11 -0.3 6.19e-7 Obesity-related traits; CESC cis rs9291683 0.645 rs11557743 chr4:10118377 C/G cg11266682 chr4:10021025 SLC2A9 -0.46 -8.38 -0.46 3.17e-15 Bone mineral density; CESC cis rs73019876 0.869 rs6511306 chr19:22163848 A/G cg11619707 chr19:22235551 ZNF257 -0.28 -5.11 -0.3 6.09e-7 Testicular germ cell tumor; CESC cis rs7937682 0.558 rs7113067 chr11:111692182 G/A cg22437258 chr11:111473054 SIK2 -0.52 -5.75 -0.33 2.48e-8 Primary sclerosing cholangitis; CESC cis rs9902453 0.967 rs62070344 chr17:28476997 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 7.93 0.44 6.11e-14 Coffee consumption (cups per day); CESC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg18876405 chr7:65276391 NA 0.51 5.96 0.34 8.21e-9 Aortic root size; CESC cis rs16854884 0.657 rs16854772 chr3:143703890 A/G cg06585982 chr3:143692056 C3orf58 0.46 5.69 0.33 3.32e-8 Economic and political preferences (feminism/equality); CESC cis rs7918232 0.941 rs10741128 chr10:27411509 G/A cg14240646 chr10:27532245 ACBD5 -0.66 -6.43 -0.37 5.89e-10 Breast cancer; CESC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg13206674 chr6:150067644 NUP43 0.46 6.59 0.38 2.41e-10 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08708209 chr1:221915487 DUSP10 0.58 6.55 0.37 3.04e-10 Gut microbiome composition (summer); CESC cis rs6736093 0.796 rs34240639 chr2:112809951 T/A cg12686935 chr2:112915763 FBLN7 -0.45 -5.95 -0.34 8.59e-9 Coronary artery disease; CESC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg22143856 chr6:28129313 ZNF389 0.52 6.53 0.37 3.27e-10 Depression; CESC cis rs1957429 0.901 rs60979440 chr14:65390231 A/G cg23373153 chr14:65346875 NA -0.9 -9.7 -0.51 3.21e-19 Pediatric areal bone mineral density (radius); CESC cis rs9291683 0.595 rs35501905 chr4:10053431 C/T cg00071950 chr4:10020882 SLC2A9 0.83 14.75 0.67 2.38e-36 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27051171 chr2:7005923 CMPK2 0.66 7.6 0.42 5.2e-13 Gut microbiome composition (summer); CESC trans rs9388451 0.626 rs9385383 chr6:126086290 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.62 -8.55 -0.46 9.67e-16 Brugada syndrome; CESC cis rs1691799 0.867 rs1168330 chr12:66763167 C/T cg16791601 chr12:66731901 HELB 0.67 10.81 0.55 8.23e-23 White blood cell count (basophil); CESC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg17971929 chr21:40555470 PSMG1 -0.6 -8.06 -0.44 2.64e-14 Menarche (age at onset); CESC trans rs2727020 0.521 rs11040408 chr11:49534880 A/T cg03929089 chr4:120376271 NA 0.61 7.21 0.4 5.74e-12 Coronary artery disease; CESC trans rs116095464 0.558 rs1812843 chr5:267658 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.38e-11 Breast cancer; CESC cis rs909674 0.775 rs4821896 chr22:39833437 T/C cg02038168 chr22:39784481 NA -0.66 -8.47 -0.46 1.72e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs6460942 0.915 rs62448602 chr7:12457145 T/G cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06474646 chr7:128864675 AHCYL2 -0.5 -6.27 -0.36 1.44e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13504215 chr3:30648325 TGFBR2 0.57 6.8 0.39 6.81e-11 Gut microbiome composition (summer); CESC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg18016565 chr1:150552671 MCL1 -0.35 -5.89 -0.34 1.15e-8 Tonsillectomy; CESC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.4 6.11 0.35 3.63e-9 Bone mineral density (hip);Bone mineral density; CESC cis rs6831352 0.879 rs29001212 chr4:100051877 T/C cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs4689388 0.926 rs4688987 chr4:6287329 C/T cg25554036 chr4:6271136 WFS1 0.55 9.01 0.48 4.27e-17 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6728642 0.808 rs114192053 chr2:97871906 G/A cg26665480 chr2:98280029 ACTR1B -0.92 -6.97 -0.39 2.47e-11 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg07507251 chr3:52567010 NT5DC2 0.34 5.92 0.34 9.68e-9 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25353064 chr10:96991431 NA 0.5 6.66 0.38 1.62e-10 Fibrinogen levels; CESC cis rs4919087 1.000 rs7076523 chr10:99089296 T/C cg25902810 chr10:99078978 FRAT1 -0.67 -8.9 -0.48 9.11e-17 Monocyte count; CESC cis rs8067545 0.611 rs16960697 chr17:20027718 A/G cg13482628 chr17:19912719 NA 0.41 5.49 0.32 9.21e-8 Schizophrenia; CESC cis rs6087990 0.806 rs910085 chr20:31383353 T/G cg13636640 chr20:31349939 DNMT3B 0.82 13.16 0.63 9.12e-31 Ulcerative colitis; CESC cis rs3859192 0.561 rs9916158 chr17:38182229 G/T cg17344932 chr17:38183730 MED24;SNORD124 0.62 9.57 0.51 7.92e-19 White blood cell count; CESC cis rs3106136 0.564 rs60428594 chr4:95103466 C/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.23 -0.36 1.8e-9 Capecitabine sensitivity; CESC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10120645 chr8:125486635 RNF139 -0.44 -6.16 -0.35 2.69e-9 Fibrinogen levels; CESC cis rs1348850 0.537 rs3770010 chr2:178537796 T/C cg23306229 chr2:178417860 TTC30B 0.53 7.01 0.4 2.03e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6831352 0.918 rs29001195 chr4:100054244 G/T cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg22535103 chr8:58192502 C8orf71 -0.9 -8.95 -0.48 6.29e-17 Developmental language disorder (linguistic errors); CESC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg14196790 chr5:131705035 SLC22A5 -0.42 -6.62 -0.38 1.93e-10 Blood metabolite levels; CESC cis rs910316 0.839 rs35977276 chr14:75637359 A/C cg11812906 chr14:75593930 NEK9 -0.88 -14.52 -0.67 1.5e-35 Height; CESC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.52 0.37 3.63e-10 Prudent dietary pattern; CESC cis rs3733585 0.673 rs9994937 chr4:9964799 G/T cg02734326 chr4:10020555 SLC2A9 -0.45 -6.29 -0.36 1.27e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7267979 1.000 rs6037105 chr20:25374199 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.13 -0.74 2.42e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs8114671 0.562 rs6088642 chr20:33483186 G/T cg06115741 chr20:33292138 TP53INP2 0.46 5.58 0.32 6.06e-8 Height; CESC cis rs2204008 0.774 rs11615665 chr12:38328162 T/A cg26384229 chr12:38710491 ALG10B 0.72 10.82 0.55 7.48e-23 Bladder cancer; CESC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg04772025 chr11:68637568 NA 0.54 6.02 0.35 5.87e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1577917 0.958 rs1591438 chr6:86525214 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.28 -0.36 1.4e-9 Response to antipsychotic treatment; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01941219 chr13:98795021 FARP1 -0.48 -6.46 -0.37 4.87e-10 Fibrinogen levels; CESC cis rs9325144 0.510 rs6582599 chr12:38715965 T/G cg26384229 chr12:38710491 ALG10B 0.56 7.75 0.43 1.93e-13 Morning vs. evening chronotype; CESC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg07677032 chr17:61819896 STRADA 0.42 5.2 0.3 3.93e-7 Height; CESC cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC trans rs1038903 0.893 rs6448594 chr4:28757925 G/T cg15651925 chr7:156259219 NA 0.48 6.11 0.35 3.51e-9 Menarche (age at onset); CESC cis rs6547741 0.874 rs28381983 chr2:27804432 T/C cg21248554 chr2:27665150 KRTCAP3 0.25 5.15 0.3 5.2e-7 Oral cavity cancer; CESC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg08470875 chr2:26401718 FAM59B 0.76 8.06 0.44 2.69e-14 Gut microbiome composition (summer); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg06481920 chr2:132431767 NA 0.5 6.36 0.36 8.99e-10 Psoriatic arthritis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18005807 chr22:18506799 MICAL3 0.46 6.15 0.35 2.84e-9 Systemic lupus erythematosus; CESC cis rs9443645 0.527 rs4706746 chr6:79674176 G/A cg05283184 chr6:79620031 NA -0.36 -5.14 -0.3 5.21e-7 Intelligence (multi-trait analysis); CESC cis rs9623117 1.000 rs9611267 chr22:40506004 C/T cg05033341 chr22:40419857 FAM83F 0.42 5.39 0.31 1.54e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg11890956 chr21:40555474 PSMG1 1.18 22.8 0.81 2.05e-64 Cognitive function; CESC cis rs4704187 0.687 rs11950665 chr5:74423339 A/G cg03227963 chr5:74354835 NA 0.31 5.65 0.33 4.17e-8 Response to amphetamines; CESC cis rs7927592 0.956 rs7124078 chr11:68298633 G/T cg20283391 chr11:68216788 NA -0.5 -5.98 -0.34 7.31e-9 Total body bone mineral density; CESC cis rs8078723 0.933 rs55846942 chr17:38164470 G/A cg17467752 chr17:38218738 THRA 0.69 10.54 0.54 6.17e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs12142240 0.698 rs932816 chr1:46859749 G/A cg10495392 chr1:46806563 NSUN4 0.56 6.17 0.35 2.61e-9 Menopause (age at onset); CESC cis rs780096 0.647 rs11682083 chr2:27752296 A/G cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.13 -0.3 5.68e-7 Total body bone mineral density; CESC cis rs8077889 0.917 rs1859048 chr17:41892039 A/C cg26893861 chr17:41843967 DUSP3 -0.64 -7.75 -0.43 1.93e-13 Triglycerides; CESC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg11644478 chr21:40555479 PSMG1 0.83 12.56 0.61 1.05e-28 Cognitive function; CESC cis rs4803468 0.934 rs2317131 chr19:41885151 C/T cg14132834 chr19:41945861 ATP5SL -0.6 -7.49 -0.42 1.02e-12 Height; CESC cis rs4076764 1.000 rs7528020 chr1:163426537 G/A cg24596788 chr1:163392923 NA -0.47 -6.85 -0.39 5.08e-11 Motion sickness; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg15986164 chr4:901785 GAK 0.44 6.39 0.37 7.53e-10 Thyroid stimulating hormone; CESC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg02269571 chr22:50332266 NA 0.47 5.99 0.35 6.85e-9 Schizophrenia; CESC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg20999797 chr1:1681921 NA 0.27 5.32 0.31 2.2e-7 Body mass index; CESC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg03576123 chr11:487126 PTDSS2 -1.09 -10.86 -0.56 5.59e-23 Body mass index; CESC cis rs2732480 0.557 rs2409004 chr12:48721451 T/C cg04545296 chr12:48745243 ZNF641 0.36 6.27 0.36 1.49e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2988277 0.737 rs1723015 chr1:167432894 T/C cg22356347 chr1:167427500 CD247 -0.31 -6.34 -0.36 1e-9 Allergic disease (asthma, hay fever or eczema); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13591497 chr9:126129566 CRB2 0.46 6.34 0.36 9.98e-10 Fibrinogen levels; CESC cis rs4950928 0.823 rs2494277 chr1:203168092 A/G cg17014757 chr1:203156097 CHI3L1 -0.54 -5.38 -0.31 1.6e-7 YKL-40 levels; CESC cis rs873946 0.586 rs12783078 chr10:134569706 C/T cg18305652 chr10:134549665 INPP5A 0.45 6.28 0.36 1.34e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7588746 0.868 rs12104649 chr2:201128832 C/T cg23649088 chr2:200775458 C2orf69 -0.53 -6.32 -0.36 1.12e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs11997175 0.549 rs4349945 chr8:33654323 T/C ch.8.33884649F chr8:33765107 NA 0.66 8.38 0.46 3.15e-15 Body mass index; CESC cis rs7809950 0.723 rs62483634 chr7:106878516 G/A cg23024343 chr7:107201750 COG5 -0.46 -5.9 -0.34 1.12e-8 Coronary artery disease; CESC cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg03433033 chr1:76189801 ACADM 0.62 7.14 0.4 8.85e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg13206674 chr6:150067644 NUP43 0.42 6.16 0.35 2.7e-9 Lung cancer; CESC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg17747265 chr1:1875780 NA 0.55 9.03 0.49 3.57e-17 Body mass index; CESC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg08888203 chr3:10149979 C3orf24 0.48 6.1 0.35 3.84e-9 Alzheimer's disease; CESC trans rs360798 0.512 rs1906200 chr2:62806598 C/T cg07814414 chr15:31774773 NA -0.42 -6.25 -0.36 1.67e-9 Coronary artery disease; CESC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.79e-7 Gut microbiome composition (summer); CESC cis rs2070488 0.775 rs2300669 chr3:38541318 C/A cg24069376 chr3:38537580 EXOG -0.34 -5.83 -0.34 1.6e-8 Electrocardiographic conduction measures; CESC cis rs1062177 0.756 rs2964589 chr5:151118189 G/T cg00977110 chr5:151150581 G3BP1 -0.6 -6.22 -0.36 1.91e-9 Preschool internalizing problems; CESC cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg14820908 chr5:178986412 RUFY1 -0.38 -5.47 -0.32 1.05e-7 Lung cancer; CESC cis rs7474896 0.537 rs1779068 chr10:38250785 G/A cg25427524 chr10:38739819 LOC399744 0.49 5.46 0.32 1.1e-7 Obesity (extreme); CESC cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg04455712 chr21:45112962 RRP1B 0.4 5.82 0.34 1.67e-8 Mean corpuscular volume; CESC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg03605463 chr16:89740564 NA 0.64 7.76 0.43 1.89e-13 Vitiligo; CESC trans rs17635075 1.000 rs2131247 chr4:167347496 C/T cg14326305 chr9:107573154 ABCA1 0.6 6.23 0.36 1.84e-9 Obesity-related traits; CESC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg05754148 chr16:3507555 NAT15 0.54 7.9 0.44 7.65e-14 Tuberculosis; CESC cis rs9287719 0.601 rs10177062 chr2:10713698 C/T cg00105475 chr2:10696890 NA 0.4 5.47 0.32 1.05e-7 Prostate cancer; CESC trans rs6600671 0.967 rs12069545 chr1:121172203 A/G cg17023122 chr1:144479586 NA 0.45 6.2 0.36 2.1e-9 Hip geometry; CESC cis rs476633 0.691 rs2164996 chr15:41536624 A/G cg18705301 chr15:41695430 NDUFAF1 -0.47 -6.82 -0.39 6.1e-11 Glomerular filtration rate (creatinine); CESC cis rs4472734 0.932 rs11120327 chr1:214626397 G/A cg00063699 chr1:214624242 PTPN14 -0.33 -5.11 -0.3 6.06e-7 Height; CESC cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg10556349 chr10:835070 NA 0.58 5.59 0.32 5.63e-8 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.76e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04108296 chr1:167691246 MPZL1 0.62 6.71 0.38 1.17e-10 Gut microbiome composition (summer); CESC cis rs9309473 1.000 rs11674602 chr2:73723185 A/T cg20560298 chr2:73613845 ALMS1 -0.56 -7.28 -0.41 3.91e-12 Metabolite levels; CESC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg19626725 chr5:178986131 RUFY1 0.39 6.06 0.35 4.67e-9 Lung cancer; CESC cis rs7312933 1.000 rs7312933 chr12:42503467 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.46 -6.0 -0.35 6.63e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs61931739 0.534 rs7965503 chr12:34199349 A/G cg13010199 chr12:38710504 ALG10B 0.48 6.0 0.35 6.54e-9 Morning vs. evening chronotype; CESC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg24642844 chr7:1081250 C7orf50 -0.68 -8.39 -0.46 2.9e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg17328964 chr8:145687451 CYHR1 0.44 6.1 0.35 3.79e-9 Age at first birth; CESC cis rs4975616 0.869 rs421284 chr5:1325590 T/C cg26373071 chr5:1325741 CLPTM1L 0.44 7.07 0.4 1.42e-11 Lung cancer; CESC trans rs1044826 1.000 rs9868544 chr3:139163154 C/T cg05129325 chr1:215255161 KCNK2 -0.34 -6.1 -0.35 3.75e-9 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13629201 chr9:5111420 JAK2 0.52 6.93 0.39 3.13e-11 Fibrinogen levels; CESC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg00310523 chr12:86230176 RASSF9 0.34 5.18 0.3 4.38e-7 Major depressive disorder; CESC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs34779708 0.931 rs7084196 chr10:35367161 T/C cg03585969 chr10:35415529 CREM 0.76 10.09 0.53 1.8e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs6780666 0.527 rs9877177 chr3:136957488 C/A cg16900796 chr19:10755136 SLC44A2 -0.42 -6.41 -0.37 6.46e-10 Intelligence (multi-trait analysis); CESC cis rs8111998 0.826 rs8108776 chr19:22765384 C/T cg19914732 chr19:22715077 NA -0.38 -5.26 -0.31 2.93e-7 Corneal structure; CESC cis rs6662572 0.737 rs72677530 chr1:46529677 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.13 0.3 5.49e-7 Blood protein levels; CESC cis rs910316 0.737 rs175077 chr14:75506875 G/A cg11812906 chr14:75593930 NEK9 -0.82 -12.97 -0.62 4.02e-30 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16755220 chr16:12070685 RUNDC2A 0.59 6.92 0.39 3.45e-11 Gut microbiome composition (summer); CESC cis rs9916302 0.821 rs11078916 chr17:37746307 T/C cg20243544 chr17:37824526 PNMT 0.56 6.88 0.39 4.37e-11 Glomerular filtration rate (creatinine); CESC cis rs2243480 0.666 rs1880311 chr7:65276752 G/C cg13147721 chr7:65941812 NA 0.86 7.92 0.44 6.53e-14 Diabetic kidney disease; CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg10819733 chr22:24237672 NA -0.44 -6.29 -0.36 1.27e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs72781680 0.848 rs56021814 chr2:24073437 T/A cg08917208 chr2:24149416 ATAD2B 0.93 8.47 0.46 1.77e-15 Lymphocyte counts; CESC cis rs6088813 1.000 rs6087704 chr20:34001058 C/T cg14752227 chr20:34000481 UQCC -0.39 -5.06 -0.3 7.88e-7 Height; CESC cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg05347473 chr6:146136440 FBXO30 -0.57 -7.36 -0.41 2.27e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1986734 0.619 rs13106227 chr4:77418681 G/A cg20311846 chr4:77356250 SHROOM3 -0.26 -5.28 -0.31 2.63e-7 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC cis rs10911251 0.546 rs3359 chr1:183112041 G/C ch.1.3577855R chr1:183094577 LAMC1 0.82 12.32 0.6 7.25e-28 Colorectal cancer; CESC cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg15605315 chr1:45957053 TESK2 0.44 5.66 0.33 3.92e-8 High light scatter reticulocyte count; CESC cis rs2708240 0.967 rs2710140 chr7:147570584 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.53 -0.32 7.72e-8 QT interval (drug interaction); CESC cis rs12973672 1.000 rs12973672 chr19:35767866 A/G cg12095397 chr19:35769544 USF2 0.54 7.33 0.41 2.81e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1348850 0.914 rs12104588 chr2:178253675 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.9 13.34 0.63 2.02e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4849845 0.704 rs4848580 chr2:121001117 A/G cg24070213 chr2:121070622 NA -0.41 -5.89 -0.34 1.16e-8 Mean platelet volume; CESC cis rs8072100 0.656 rs2610367 chr17:45569815 A/G cg08085267 chr17:45401833 C17orf57 -0.51 -6.57 -0.37 2.63e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27513886 chr16:31073034 ZNF668 0.46 6.23 0.36 1.83e-9 Fibrinogen levels; CESC cis rs9291683 0.588 rs3796829 chr4:10019138 C/G cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.51e-12 Bone mineral density; CESC cis rs3833788 1 rs3833788 chr12:121151062 CTCTCTTG/C cg21892295 chr12:121157589 UNC119B -0.42 -6.65 -0.38 1.66e-10 Mean corpuscular hemoglobin; CESC cis rs2562784 0.638 rs2585054 chr15:84273328 A/G cg17507749 chr15:85114479 UBE2QP1 -0.52 -5.04 -0.3 8.44e-7 Height; CESC cis rs7267005 0.661 rs2425110 chr20:34318815 A/C cg04508476 chr20:34239394 CPNE1;RBM12 0.95 5.86 0.34 1.39e-8 Response to paliperidone in schizophrenia (Multivariate); CESC cis rs72781680 0.898 rs113522526 chr2:24018476 C/T cg20701182 chr2:24300061 SF3B14 0.63 5.59 0.32 5.62e-8 Lymphocyte counts; CESC cis rs27434 0.583 rs34764 chr5:96155229 A/G cg16492584 chr5:96139282 ERAP1 -0.38 -5.47 -0.32 1.04e-7 Ankylosing spondylitis; CESC cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.83 7.54 0.42 7.47e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs7582180 0.700 rs1437971 chr2:100986964 A/C cg14257593 chr9:36191184 CLTA 0.61 6.35 0.36 9.13e-10 Intelligence (multi-trait analysis); CESC cis rs8044868 0.530 rs2288000 chr16:72058881 A/G cg01557791 chr16:72042693 DHODH -0.46 -6.36 -0.36 8.8e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg18446336 chr7:2847575 GNA12 -0.45 -7.53 -0.42 7.78e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17481046 chr3:40547578 ZNF620 -0.42 -6.46 -0.37 4.93e-10 Gambling; CESC cis rs1020064 0.636 rs2576726 chr2:105936412 A/G cg02079111 chr2:105885981 TGFBRAP1 0.39 5.27 0.31 2.77e-7 AIDS; CESC cis rs4253772 0.872 rs4253776 chr22:46629479 C/T cg24881330 chr22:46731750 TRMU -0.55 -5.17 -0.3 4.57e-7 LDL cholesterol;Cholesterol, total; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G ch.20.234237F chr20:10626720 JAG1 0.38 6.12 0.35 3.32e-9 Gambling; CESC cis rs2645694 0.533 rs2645681 chr4:77820949 G/A cg10057126 chr4:77819792 ANKRD56 0.59 8.61 0.47 6.84e-16 Emphysema distribution in smoking; CESC cis rs926392 0.692 rs6028259 chr20:37696977 T/A cg16355469 chr20:37678765 NA 0.5 5.56 0.32 6.59e-8 Dialysis-related mortality; CESC cis rs6484504 0.576 rs208103 chr11:31167400 A/G cg14844989 chr11:31128820 NA -0.43 -6.13 -0.35 3.25e-9 Red blood cell count; CESC cis rs7264396 0.790 rs3787164 chr20:34228866 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 3.02e-26 Total cholesterol levels; CESC cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg25019033 chr10:957182 NA -0.52 -5.12 -0.3 5.91e-7 Eosinophil percentage of granulocytes; CESC cis rs2243480 1.000 rs1039664 chr7:65449716 T/G cg12463550 chr7:65579703 CRCP 0.72 5.92 0.34 9.68e-9 Diabetic kidney disease; CESC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg26441486 chr22:50317300 CRELD2 0.42 5.24 0.31 3.33e-7 Schizophrenia; CESC cis rs870825 0.616 rs6552807 chr4:185640531 A/G cg04058563 chr4:185651563 MLF1IP 0.65 7.16 0.4 8e-12 Blood protein levels; CESC cis rs10876993 0.928 rs1628552 chr12:58082142 C/T cg18357645 chr12:58087776 OS9 0.63 10.41 0.54 1.67e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs2204008 0.563 rs2320512 chr12:38266913 G/A cg26384229 chr12:38710491 ALG10B -0.44 -5.7 -0.33 3.11e-8 Bladder cancer; CESC cis rs644799 1.000 rs586498 chr11:95537828 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.91 13.67 0.64 1.45e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11122272 0.735 rs2474625 chr1:231519331 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06611277 chr10:26987120 PDSS1 0.48 6.16 0.35 2.7e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.16 0.3 4.94e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8060686 0.641 rs118035472 chr16:68242311 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.01 -0.35 5.98e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -11.14 -0.56 6.81e-24 Initial pursuit acceleration; CESC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 8.57 0.47 8.48e-16 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13748577 chr7:148787770 ZNF786 0.56 6.22 0.36 1.89e-9 Gut microbiome composition (summer); CESC cis rs11577318 0.796 rs4625269 chr1:26626967 C/A cg00852783 chr1:26633632 UBXN11 0.5 6.99 0.39 2.17e-11 Granulocyte percentage of myeloid white cells; CESC cis rs7107174 1.000 rs2450131 chr11:77944568 A/C cg02023728 chr11:77925099 USP35 0.52 6.81 0.39 6.37e-11 Testicular germ cell tumor; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.39 -5.81 -0.34 1.8e-8 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16889839 chr12:132547279 EP400 -0.58 -6.8 -0.39 6.87e-11 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10663503 chr17:8126298 C17orf44 -0.52 -6.87 -0.39 4.69e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.05 0.35 4.95e-9 Colorectal cancer; CESC cis rs1153858 1.000 rs72623915 chr15:45647433 C/T cg21132104 chr15:45694354 SPATA5L1 0.84 11.4 0.57 9.5e-25 Homoarginine levels; CESC cis rs11098499 0.954 rs10017543 chr4:120321420 G/A cg24375607 chr4:120327624 NA 0.49 5.97 0.34 7.73e-9 Corneal astigmatism; CESC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg15352829 chr14:105391018 PLD4 -0.6 -10.51 -0.54 8.09e-22 Rheumatoid arthritis; CESC cis rs1348850 0.526 rs6718769 chr2:178450909 T/C cg23306229 chr2:178417860 TTC30B 0.75 7.12 0.4 1.02e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3741798 0.901 rs61922024 chr12:12485881 C/A cg08615371 chr12:12503544 MANSC1 0.87 6.35 0.36 9.19e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7072216 0.691 rs3829853 chr10:100171174 A/G cg26618903 chr10:100175079 PYROXD2 -0.38 -5.79 -0.34 1.99e-8 Metabolite levels; CESC cis rs7727544 0.684 rs274567 chr5:131714409 C/T cg24060327 chr5:131705240 SLC22A5 0.62 8.19 0.45 1.11e-14 Blood metabolite levels; CESC cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg05340658 chr4:99064831 C4orf37 0.81 12.03 0.59 6.66e-27 Colonoscopy-negative controls vs population controls; CESC cis rs77741769 0.569 rs10774572 chr12:121309561 A/G cg02419362 chr12:121203948 SPPL3 0.34 5.59 0.32 5.6e-8 Mean corpuscular volume; CESC cis rs2731664 0.792 rs335452 chr5:176879671 C/T cg23176889 chr5:176863531 GRK6 -0.62 -11.01 -0.56 1.88e-23 Intelligence (multi-trait analysis); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg16354296 chr10:112257617 DUSP5 0.43 6.09 0.35 3.97e-9 Vertical cup-disc ratio; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09317403 chr14:92994936 RIN3 -0.39 -6.06 -0.35 4.65e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7249142 0.549 rs2239369 chr19:19292405 A/T cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B -0.29 -5.33 -0.31 2.09e-7 IgG glycosylation; CESC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg11890956 chr21:40555474 PSMG1 -0.97 -16.67 -0.72 3.63e-43 Cognitive function; CESC cis rs2180341 0.960 rs6913424 chr6:127707010 A/C cg27446573 chr6:127587934 RNF146 1.03 14.89 0.67 7.67e-37 Breast cancer; CESC cis rs826838 1.000 rs11168218 chr12:38884466 A/G cg13010199 chr12:38710504 ALG10B 0.6 8.51 0.46 1.26e-15 Heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06867065 chr19:51871233 CLDND2 -0.52 -6.17 -0.35 2.48e-9 Gut microbiome composition (summer); CESC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg27266027 chr21:40555129 PSMG1 0.45 5.23 0.31 3.38e-7 Cognitive function; CESC cis rs8064299 0.597 rs4789097 chr17:72781208 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.87 -14.99 -0.68 3.29e-37 Monocyte count; CESC cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg17971929 chr21:40555470 PSMG1 0.62 8.0 0.44 3.93e-14 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05315670 chr11:64037304 BAD 0.6 6.86 0.39 4.78e-11 Gut microbiome composition (summer); CESC cis rs4728302 0.869 rs13231079 chr7:133604373 C/G cg10665199 chr7:133106180 EXOC4 0.4 5.56 0.32 6.62e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg11764359 chr7:65958608 NA -0.73 -10.44 -0.54 1.38e-21 Aortic root size; CESC cis rs9399135 0.636 rs4646871 chr6:135265617 A/G cg24558204 chr6:135376177 HBS1L -0.58 -8.23 -0.45 8.64e-15 Red blood cell count; CESC trans rs1814175 0.803 rs11040451 chr11:49650639 C/T cg03929089 chr4:120376271 NA -0.87 -13.23 -0.63 4.97e-31 Height; CESC cis rs6991838 0.584 rs34226237 chr8:66513165 A/C cg13398993 chr8:66546079 ARMC1 -0.47 -5.79 -0.34 1.98e-8 Intelligence (multi-trait analysis); CESC cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg05340658 chr4:99064831 C4orf37 0.69 9.36 0.5 3.49e-18 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg06784218 chr1:46089804 CCDC17 -0.3 -5.16 -0.3 4.9e-7 High light scatter reticulocyte count; CESC cis rs751837 0.591 rs2896462 chr14:103434739 A/G cg10087771 chr14:103399429 CDC42BPB 0.67 6.08 0.35 4.07e-9 Large B-cell lymphoma; CESC cis rs2439831 0.681 rs498837 chr15:43608024 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.9 11.12 0.56 7.77e-24 Lung cancer in ever smokers; CESC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg11764359 chr7:65958608 NA 0.81 11.81 0.59 3.86e-26 Aortic root size; CESC cis rs4141404 0.706 rs5753698 chr22:31970054 A/C cg02404636 chr22:31891804 SFI1 0.42 5.76 0.33 2.32e-8 Paclitaxel-induced neuropathy; CESC cis rs4803468 0.967 rs7259900 chr19:41889429 A/T cg14132834 chr19:41945861 ATP5SL -0.64 -8.0 -0.44 4.02e-14 Height; CESC cis rs7623687 1.000 rs7623687 chr3:49448566 A/C cg19401529 chr3:49056140 DALRD3 0.6 5.27 0.31 2.78e-7 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CESC cis rs9522267 0.535 rs12583489 chr13:112233455 G/A cg10483660 chr13:112241077 NA -0.33 -5.79 -0.33 2.04e-8 Hepatitis; CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg23404562 chr10:115615082 NHLRC2;DCLRE1A 0.55 6.41 0.37 6.46e-10 Endometrial cancer; CESC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg08027265 chr7:2291960 NA -0.38 -6.01 -0.35 6.23e-9 Schizophrenia; CESC cis rs9818758 0.607 rs5030795 chr3:49141116 C/T cg00383909 chr3:49044727 WDR6 0.84 6.44 0.37 5.59e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09157727 chr15:96873850 NR2F2 0.47 6.13 0.35 3.22e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs644799 0.687 rs11021318 chr11:95522996 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.31 0.57 1.89e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs929354 0.772 rs6967764 chr7:156994964 C/T cg05182265 chr7:156933206 UBE3C -0.51 -7.49 -0.42 1.02e-12 Body mass index; CESC cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg05347473 chr6:146136440 FBXO30 -0.71 -9.16 -0.49 1.42e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs6598955 0.724 rs12757113 chr1:26597144 C/T cg00852783 chr1:26633632 UBXN11 0.4 5.8 0.34 1.92e-8 Obesity-related traits; CESC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg23172400 chr8:95962367 TP53INP1 -0.42 -8.67 -0.47 4.42e-16 Type 2 diabetes; CESC cis rs6500395 1.000 rs7188741 chr16:48607966 T/C cg04672837 chr16:48644449 N4BP1 0.52 6.51 0.37 3.68e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs10129255 0.536 rs3944157 chr14:107138303 C/T cg07958169 chr14:107095056 NA -0.44 -6.51 -0.37 3.79e-10 Kawasaki disease; CESC cis rs7216064 0.953 rs9890629 chr17:65871559 G/A cg12091567 chr17:66097778 LOC651250 -0.81 -9.07 -0.49 2.67e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7605827 0.930 rs4668905 chr2:15543776 C/A cg19274914 chr2:15703543 NA 0.34 6.12 0.35 3.44e-9 Educational attainment (years of education); CESC trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg03929089 chr4:120376271 NA -0.91 -15.43 -0.69 9.49e-39 Height; CESC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg11366901 chr6:160182831 ACAT2 0.82 10.7 0.55 1.96e-22 Age-related macular degeneration (geographic atrophy); CESC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.0 0.56 1.99e-23 Platelet count; CESC cis rs73206853 0.764 rs7960705 chr12:111084540 G/A cg12870014 chr12:110450643 ANKRD13A 0.65 5.59 0.32 5.71e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg19729930 chr2:74357872 NA 0.9 13.71 0.64 1.09e-32 Gestational age at birth (maternal effect); CESC cis rs7520050 0.966 rs1085243 chr1:46544768 C/T cg03146154 chr1:46216737 IPP -0.44 -5.69 -0.33 3.34e-8 Red blood cell count;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10295110 chr16:4524375 NMRAL1;HMOX2 0.55 6.26 0.36 1.59e-9 Gut microbiome composition (summer); CESC cis rs2637266 0.626 rs724113 chr10:78557309 C/T cg18941641 chr10:78392320 NA 0.41 7.77 0.43 1.73e-13 Pulmonary function; CESC trans rs9937837 1.000 rs35466388 chr16:31314599 T/C cg04903759 chr3:167238645 WDR49 0.53 6.63 0.38 1.89e-10 Systemic lupus erythematosus; CESC cis rs10911232 0.507 rs61081633 chr1:182995608 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC trans rs11098499 0.863 rs10018280 chr4:120478139 T/G cg25214090 chr10:38739885 LOC399744 0.67 9.15 0.49 1.52e-17 Corneal astigmatism; CESC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg23131131 chr22:24373011 LOC391322 -0.67 -9.2 -0.49 1.09e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs939658 0.805 rs11638625 chr15:79434787 T/G cg17916960 chr15:79447300 NA -0.38 -6.32 -0.36 1.1e-9 Refractive error; CESC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -6.81 -0.39 6.34e-11 Bipolar disorder; CESC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg24399712 chr22:39784796 NA 0.81 11.34 0.57 1.44e-24 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs314370 0.951 rs17881696 chr7:100493359 G/A cg10426581 chr7:100472382 SRRT 0.84 8.18 0.45 1.23e-14 Resting heart rate; CESC cis rs11155671 0.530 rs6939761 chr6:150210994 T/C cg09699651 chr6:150184138 LRP11 0.55 7.7 0.43 2.78e-13 Testicular germ cell tumor; CESC cis rs11608355 0.515 rs2287192 chr12:109931594 C/T cg05360138 chr12:110035743 NA 0.8 8.55 0.46 1.02e-15 Neuroticism; CESC cis rs2370759 1.000 rs16933243 chr10:32615135 T/C cg18270830 chr10:32634957 EPC1 0.71 6.75 0.38 9.32e-11 Sexual dysfunction (female); CESC cis rs826838 0.904 rs7973992 chr12:39168233 T/C cg13010199 chr12:38710504 ALG10B 0.58 8.08 0.44 2.27e-14 Heart rate; CESC trans rs1945213 0.659 rs17149979 chr11:55840862 A/G cg03929089 chr4:120376271 NA 0.76 7.26 0.41 4.31e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs28374715 0.783 rs11635269 chr15:41570710 A/G cg18705301 chr15:41695430 NDUFAF1 -0.98 -14.36 -0.66 5.43e-35 Ulcerative colitis; CESC cis rs7107174 1.000 rs4944198 chr11:78032605 T/A cg02023728 chr11:77925099 USP35 0.43 6.08 0.35 4.2e-9 Testicular germ cell tumor; CESC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.07 -0.3 7.42e-7 Total body bone mineral density; CESC cis rs9611565 0.681 rs6002372 chr22:41801299 A/T cg06634786 chr22:41940651 POLR3H 0.73 7.47 0.42 1.2e-12 Vitiligo; CESC cis rs7216064 1.000 rs3935969 chr17:65881959 A/G cg12091567 chr17:66097778 LOC651250 -0.81 -9.2 -0.49 1.14e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2073300 1.000 rs6114101 chr20:23446322 C/T cg12062639 chr20:23401060 NAPB 0.85 6.22 0.36 1.93e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6963495 0.818 rs73190186 chr7:105164368 G/C cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs12136530 0.669 rs10917449 chr1:19756869 A/G cg01832549 chr1:19774989 CAPZB -0.48 -6.43 -0.37 5.97e-10 Lead levels in blood; CESC cis rs7098414 0.511 rs7916349 chr10:82152638 G/A cg00277334 chr10:82204260 NA -0.5 -7.37 -0.41 2.23e-12 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06041985 chr20:442822 TBC1D20 0.57 6.42 0.37 6.44e-10 Gut microbiome composition (summer); CESC cis rs748404 0.697 rs572959 chr15:43550502 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.08 0.44 2.31e-14 Lung cancer; CESC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg24549020 chr5:56110836 MAP3K1 0.49 6.06 0.35 4.56e-9 Coronary artery disease; CESC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 -0.94 -9.45 -0.5 1.86e-18 Platelet count; CESC cis rs7772486 0.790 rs6570723 chr6:146151230 A/T cg23711669 chr6:146136114 FBXO30 0.9 13.27 0.63 3.71e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs1570884 0.556 rs2146146 chr13:50170368 C/T cg03651054 chr13:50194643 NA 0.31 5.08 0.3 7.07e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs265548 0.608 rs36690 chr19:17910483 C/T cg16024904 chr19:17905718 B3GNT3 0.44 5.84 0.34 1.54e-8 Tumor biomarkers; CESC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg19622623 chr12:86230825 RASSF9 -0.46 -5.92 -0.34 9.94e-9 Major depressive disorder; CESC cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg24733560 chr20:60626293 TAF4 0.44 6.41 0.37 6.64e-10 Body mass index; CESC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg00684032 chr4:1343700 KIAA1530 0.41 5.77 0.33 2.22e-8 Obesity-related traits; CESC cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.04 9.88 0.52 8.25e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25458520 chr6:36099195 MAPK13 -0.42 -6.5 -0.37 3.86e-10 Gambling; CESC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg24549020 chr5:56110836 MAP3K1 -0.58 -6.24 -0.36 1.73e-9 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19717193 chr7:105162577 PUS7 0.57 6.6 0.38 2.26e-10 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.49 0.32 9.47e-8 Bipolar disorder; CESC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg26314531 chr2:26401878 FAM59B -0.62 -7.07 -0.4 1.37e-11 Gut microbiome composition (summer); CESC cis rs9611565 0.694 rs5758347 chr22:41821019 G/T cg17376030 chr22:41985996 PMM1 -0.76 -8.01 -0.44 3.71e-14 Vitiligo; CESC cis rs7208859 0.623 rs34756112 chr17:29113016 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg07537917 chr2:241836409 C2orf54 -0.25 -5.51 -0.32 8.67e-8 Urinary metabolites; CESC cis rs561341 1.000 rs55643307 chr17:30263074 T/C cg12193833 chr17:30244370 NA -0.71 -6.37 -0.36 8.43e-10 Hip circumference adjusted for BMI; CESC cis rs1552244 0.554 rs17050704 chr3:10045734 T/C cg00149659 chr3:10157352 C3orf10 0.54 6.63 0.38 1.89e-10 Alzheimer's disease; CESC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg04369109 chr6:150039330 LATS1 -0.36 -5.03 -0.3 9.18e-7 Lung cancer; CESC cis rs11078597 0.671 rs1045806 chr17:1641806 G/A cg18436246 chr17:1640651 WDR81 0.62 7.59 0.42 5.36e-13 Serum albumin level; CESC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg26338869 chr17:61819248 STRADA 0.67 8.85 0.48 1.3e-16 Prudent dietary pattern; CESC cis rs7267979 0.844 rs2424703 chr20:25270124 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.79 14.56 0.67 1.07e-35 Liver enzyme levels (alkaline phosphatase); CESC trans rs11088226 0.846 rs2154500 chr21:33926391 T/C cg09050820 chr6:167586206 TCP10L2 0.63 6.81 0.39 6.42e-11 Gastritis; CESC cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.69 6.47 0.37 4.72e-10 Initial pursuit acceleration; CESC cis rs4253772 0.575 rs9615956 chr22:46749634 C/T cg24881330 chr22:46731750 TRMU 0.76 5.07 0.3 7.46e-7 LDL cholesterol;Cholesterol, total; CESC cis rs8018808 0.935 rs17824034 chr14:77878683 A/G cg20045696 chr14:77926864 AHSA1 0.47 6.42 0.37 6.33e-10 Myeloid white cell count; CESC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg22823121 chr1:150693482 HORMAD1 -0.41 -6.29 -0.36 1.31e-9 Tonsillectomy; CESC cis rs7605827 0.930 rs7590340 chr2:15601441 C/T cg19274914 chr2:15703543 NA 0.37 6.72 0.38 1.13e-10 Educational attainment (years of education); CESC cis rs6060717 0.536 rs11167279 chr20:34509107 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.61 0.33 4.97e-8 Hip circumference adjusted for BMI; CESC cis rs9908102 0.710 rs73981622 chr17:12914834 A/C cg26162695 chr17:12921313 ELAC2 0.53 5.73 0.33 2.68e-8 Schizophrenia; CESC cis rs694739 0.628 rs508168 chr11:64135435 G/A cg02228329 chr11:64053129 BAD;GPR137 0.62 7.67 0.43 3.25e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs8114671 0.528 rs6119542 chr20:33484545 G/T cg07148914 chr20:33460835 GGT7 0.46 6.13 0.35 3.19e-9 Height; CESC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg13175981 chr1:150552382 MCL1 0.45 5.54 0.32 7.46e-8 Urate levels; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg14039299 chr9:135251409 TTF1 -0.51 -6.88 -0.39 4.3e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs11958404 0.932 rs72816600 chr5:157436349 T/C cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs6831352 0.918 rs2851249 chr4:100044822 T/C cg12011299 chr4:100065546 ADH4 0.59 6.66 0.38 1.56e-10 Alcohol dependence; CESC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg18402987 chr7:1209562 NA 0.72 7.39 0.41 1.94e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs858239 0.738 rs7807879 chr7:23260588 G/T cg23682824 chr7:23144976 KLHL7 0.47 5.82 0.34 1.66e-8 Cerebrospinal fluid biomarker levels; CESC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg21782813 chr7:2030301 MAD1L1 0.41 5.82 0.34 1.72e-8 Bipolar disorder and schizophrenia; CESC cis rs62064224 0.533 rs11657826 chr17:30790386 T/A cg25809561 chr17:30822961 MYO1D 0.62 8.98 0.48 5.34e-17 Schizophrenia; CESC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg18904891 chr8:8559673 CLDN23 0.7 8.04 0.44 3.06e-14 Obesity-related traits; CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg15147215 chr3:52552868 STAB1 -0.29 -5.24 -0.31 3.27e-7 Bipolar disorder; CESC trans rs7615952 0.599 rs2333408 chr3:125732098 G/A cg07211511 chr3:129823064 LOC729375 -0.58 -6.92 -0.39 3.34e-11 Blood pressure (smoking interaction); CESC cis rs2732480 0.500 rs2932093 chr12:48648271 G/T cg04545296 chr12:48745243 ZNF641 0.4 6.67 0.38 1.48e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs10208940 0.764 rs6741037 chr2:68787042 C/T cg12452813 chr2:68675892 NA 0.52 5.25 0.31 3.12e-7 Urate levels in lean individuals; CESC cis rs17253792 0.822 rs10137885 chr14:56173590 A/G cg01858014 chr14:56050164 KTN1 -0.75 -6.77 -0.38 8.09e-11 Putamen volume; CESC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg03526776 chr6:41159608 TREML2 0.39 6.83 0.39 5.73e-11 Alzheimer's disease (late onset); CESC cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg10523679 chr1:76189770 ACADM -0.7 -8.07 -0.44 2.39e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs561341 0.883 rs7406056 chr17:30220224 C/T cg13647721 chr17:30228624 UTP6 0.61 5.73 0.33 2.74e-8 Hip circumference adjusted for BMI; CESC cis rs858239 0.669 rs1990365 chr7:23115966 T/C cg23682824 chr7:23144976 KLHL7 0.48 6.59 0.38 2.38e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7264396 0.790 rs2207889 chr20:34224898 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.56 0.42 6.68e-13 Total cholesterol levels; CESC cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg06022373 chr22:39101656 GTPBP1 0.91 14.78 0.67 1.9e-36 Menopause (age at onset); CESC trans rs6089829 0.925 rs4809270 chr20:61676709 C/A cg23505145 chr19:12996616 KLF1 0.52 6.45 0.37 5.33e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs11098499 0.698 rs4422403 chr4:120258194 C/T cg09307838 chr4:120376055 NA 0.76 10.33 0.54 3.02e-21 Corneal astigmatism; CESC cis rs2832191 0.791 rs2832199 chr21:30498501 G/A cg08807101 chr21:30365312 RNF160 -0.73 -10.05 -0.53 2.35e-20 Dental caries; CESC cis rs7267979 0.966 rs6050567 chr20:25354561 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.85e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2635047 0.542 rs2668772 chr18:44770621 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.33 5.16 0.3 4.74e-7 Educational attainment; CESC cis rs35079168 0.809 rs11103483 chr9:137287874 G/A cg00753924 chr9:137298813 RXRA -0.36 -5.56 -0.32 6.58e-8 Intelligence; CESC cis rs3806843 0.966 rs3756338 chr5:140180561 A/G cg26395211 chr5:140044315 WDR55 -0.42 -5.36 -0.31 1.85e-7 Depressive symptoms (multi-trait analysis); CESC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg02725872 chr8:58115012 NA -0.39 -5.09 -0.3 6.88e-7 Developmental language disorder (linguistic errors); CESC cis rs2412208 0.527 rs4436414 chr1:7120915 G/A cg20434152 chr1:7120926 CAMTA1 -0.35 -5.7 -0.33 3.26e-8 Survival in sporadic amyotrophic lateral sclerosis; CESC cis rs4588572 0.643 rs10063742 chr5:77759362 A/G cg11547950 chr5:77652471 NA -0.44 -5.48 -0.32 9.67e-8 Triglycerides; CESC cis rs17253792 0.822 rs79022053 chr14:56071721 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs6088580 0.634 rs6088478 chr20:32971719 T/C cg06115741 chr20:33292138 TP53INP2 -0.46 -5.96 -0.34 7.8e-9 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.54 -6.96 -0.39 2.64e-11 Prudent dietary pattern; CESC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg00310523 chr12:86230176 RASSF9 -0.31 -5.04 -0.3 8.55e-7 Major depressive disorder; CESC trans rs72996113 0.702 rs11224393 chr11:100569021 A/G cg01999051 chr6:166797738 BRP44L 0.7 6.08 0.35 4.17e-9 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs1790761 0.554 rs3758938 chr11:67402362 T/G cg14500267 chr11:67383377 NA -0.34 -5.14 -0.3 5.33e-7 Mean corpuscular volume; CESC cis rs727563 0.565 rs132774 chr22:42031953 C/G cg06481639 chr22:41940642 POLR3H -0.52 -6.02 -0.35 5.66e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs6495122 0.699 rs2168518 chr15:75081078 G/A cg09165964 chr15:75287851 SCAMP5 0.4 5.23 0.31 3.46e-7 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg05585544 chr11:47624801 NA -0.49 -7.37 -0.41 2.16e-12 Subjective well-being; CESC cis rs8114671 0.562 rs6087651 chr20:33518353 C/T cg07148914 chr20:33460835 GGT7 0.46 6.13 0.35 3.19e-9 Height; CESC cis rs11690935 0.959 rs4668412 chr2:172619770 A/G cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.95 -0.68 4.66e-37 Schizophrenia; CESC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg08470875 chr2:26401718 FAM59B -0.7 -7.43 -0.41 1.54e-12 Gut microbiome composition (summer); CESC cis rs2243480 0.908 rs1532573 chr7:65798802 A/G cg18252515 chr7:66147081 NA 1.41 14.58 0.67 9.57e-36 Diabetic kidney disease; CESC cis rs11051970 0.559 rs11051973 chr12:32541912 G/T cg24626660 chr12:32551988 NA 0.38 5.12 0.3 5.82e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg12311346 chr5:56204834 C5orf35 -0.76 -9.27 -0.49 6.68e-18 Initial pursuit acceleration; CESC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.92 10.16 0.53 1.05e-20 Attention deficit hyperactivity disorder; CESC cis rs6088580 0.634 rs1205344 chr20:32918298 G/A cg24642439 chr20:33292090 TP53INP2 -0.51 -6.66 -0.38 1.53e-10 Glomerular filtration rate (creatinine); CESC cis rs11864453 0.762 rs6416742 chr16:72149061 C/T cg16558253 chr16:72132732 DHX38 -0.56 -8.87 -0.48 1.11e-16 Fibrinogen levels; CESC cis rs2230307 0.536 rs629340 chr1:100538621 A/T cg24955406 chr1:100503596 HIAT1 0.53 5.41 0.32 1.38e-7 Carotid intima media thickness; CESC cis rs12145833 0.596 rs61833906 chr1:243419706 T/C cg02356786 chr1:243265016 LOC731275 0.77 5.81 0.34 1.8e-8 Obesity (early onset extreme); CESC cis rs7188697 0.922 rs6499962 chr16:58610750 A/C cg21335942 chr16:58549945 SETD6 -0.45 -5.24 -0.31 3.34e-7 QT interval; CESC cis rs17253792 0.731 rs74823888 chr14:56049800 T/C cg01858014 chr14:56050164 KTN1 -0.99 -7.44 -0.42 1.43e-12 Putamen volume; CESC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.46e-17 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09156115 chr16:56553898 BBS2 0.56 6.27 0.36 1.45e-9 Gut microbiome composition (summer); CESC cis rs10887741 0.690 rs11202503 chr10:89440749 T/G cg13926569 chr10:89418898 PAPSS2 0.36 5.36 0.31 1.79e-7 Exercise (leisure time); CESC cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg27347728 chr4:17578864 LAP3 0.45 5.16 0.3 4.96e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23385838 chr12:1755068 WNT5B -0.59 -6.82 -0.39 6.02e-11 Gut microbiome composition (summer); CESC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg05025164 chr4:1340916 KIAA1530 -0.66 -9.05 -0.49 3.22e-17 Obesity-related traits; CESC cis rs9549367 0.789 rs2287248 chr13:113889226 T/C cg00898013 chr13:113819073 PROZ -0.5 -6.86 -0.39 4.95e-11 Platelet distribution width; CESC cis rs2070488 0.699 rs13064938 chr3:38440237 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 12.46 0.61 2.31e-28 Electrocardiographic conduction measures; CESC cis rs3820068 0.581 rs34453754 chr1:15993208 G/C cg16988262 chr1:15930761 NA 0.33 5.24 0.31 3.32e-7 Systolic blood pressure; CESC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.2e-17 Prudent dietary pattern; CESC cis rs6904897 0.563 rs6569976 chr6:135224753 A/C cg22676075 chr6:135203613 NA 0.65 9.46 0.5 1.77e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7714584 0.793 rs11955174 chr5:150254391 T/G cg22134413 chr5:150180641 NA 0.51 5.92 0.34 9.88e-9 Crohn's disease; CESC cis rs7692995 1.000 rs7663818 chr4:17936443 C/T cg08925142 chr4:18023851 LCORL -0.46 -5.31 -0.31 2.29e-7 Height; CESC cis rs9291683 0.546 rs6829727 chr4:10051672 A/C cg11266682 chr4:10021025 SLC2A9 0.6 11.3 0.57 2.06e-24 Bone mineral density; CESC cis rs11711311 1.000 rs9811353 chr3:113483979 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.73 10.31 0.54 3.51e-21 IgG glycosylation; CESC cis rs3857536 0.813 rs9294688 chr6:66945904 C/T cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs9796 0.621 rs58109657 chr15:41471750 A/G cg12386646 chr15:41787261 ITPKA -0.34 -5.29 -0.31 2.52e-7 Menopause (age at onset); CESC cis rs72901758 0.768 rs1567237 chr17:76246294 A/G cg25512537 chr17:76250053 NA -0.38 -5.29 -0.31 2.62e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 9.86e-9 Prudent dietary pattern; CESC cis rs7107174 1.000 rs72931690 chr11:78073192 G/A cg02023728 chr11:77925099 USP35 0.47 6.18 0.35 2.45e-9 Testicular germ cell tumor; CESC cis rs12474201 0.832 rs6738426 chr2:46986416 A/G cg06386533 chr2:46925753 SOCS5 0.83 11.43 0.57 7.16e-25 Height; CESC cis rs7474896 0.522 rs117157955 chr10:37984164 G/T cg25427524 chr10:38739819 LOC399744 -0.46 -5.28 -0.31 2.75e-7 Obesity (extreme); CESC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg17178900 chr1:205818956 PM20D1 0.8 11.89 0.59 2.07e-26 Menarche (age at onset); CESC cis rs66887589 0.934 rs12648182 chr4:120503891 T/A cg09307838 chr4:120376055 NA -0.52 -7.0 -0.4 2.1e-11 Diastolic blood pressure; CESC cis rs7605827 0.930 rs11674824 chr2:15537429 G/A cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg03433033 chr1:76189801 ACADM -0.59 -6.13 -0.35 3.21e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6032067 0.929 rs17424723 chr20:43814520 G/T cg11264863 chr20:43835661 SEMG1 -0.53 -5.71 -0.33 2.95e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12115567 chr11:6255973 FAM160A2 0.58 6.41 0.37 6.55e-10 Gut microbiome composition (summer); CESC cis rs1941023 0.584 rs2233252 chr11:60157107 T/G cg08716584 chr11:60157161 MS4A7 -0.6 -10.18 -0.53 9e-21 Congenital heart disease (maternal effect); CESC cis rs6540556 0.954 rs6696463 chr1:209933757 G/C cg05527609 chr1:210001259 C1orf107 -0.45 -5.63 -0.33 4.66e-8 Red blood cell count; CESC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 11.28 0.57 2.27e-24 Platelet count; CESC cis rs4132509 1.000 rs6659180 chr1:243995348 C/T cg21452805 chr1:244014465 NA 0.45 5.65 0.33 4.13e-8 RR interval (heart rate); CESC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg18402987 chr7:1209562 NA 0.76 7.56 0.42 6.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6500395 1.000 rs12934126 chr16:48705951 C/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2295499 0.754 rs16843272 chr4:2717515 G/A cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.2 -0.3 4.03e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg00129232 chr17:37814104 STARD3 -0.55 -7.33 -0.41 2.87e-12 Glomerular filtration rate (creatinine); CESC cis rs5167 0.504 rs4803779 chr19:45456497 T/C cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.51e-10 Blood protein levels; CESC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg18876405 chr7:65276391 NA 0.53 7.32 0.41 3.01e-12 Aortic root size; CESC cis rs2012796 0.957 rs7151434 chr14:81819468 A/G cg02996355 chr14:81879375 NA 0.49 5.84 0.34 1.52e-8 Night sleep phenotypes; CESC cis rs3785574 0.621 rs1051684 chr17:62006497 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.51 -6.43 -0.37 6e-10 Height; CESC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg07677032 chr17:61819896 STRADA 0.46 6.17 0.35 2.58e-9 Prudent dietary pattern; CESC cis rs9916302 0.904 rs11078915 chr17:37715426 T/C cg15445000 chr17:37608096 MED1 0.42 6.83 0.39 5.67e-11 Glomerular filtration rate (creatinine); CESC trans rs1814175 0.586 rs10769603 chr11:49688837 T/C cg03929089 chr4:120376271 NA -0.84 -11.79 -0.59 4.67e-26 Height; CESC cis rs8067545 1.000 rs1860302 chr17:19914399 T/A cg13482628 chr17:19912719 NA 0.42 5.66 0.33 4e-8 Schizophrenia; CESC cis rs2929278 0.589 rs2411284 chr15:44038899 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.53 -6.96 -0.39 2.74e-11 Schizophrenia; CESC cis rs2717559 0.522 rs35816096 chr8:143884938 C/T cg17252645 chr8:143867129 LY6D -0.31 -5.44 -0.32 1.22e-7 Urinary tract infection frequency; CESC cis rs12220238 1.000 rs11000925 chr10:75972601 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.45 0.32 1.13e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs6748734 1.000 rs7604393 chr2:241825034 T/G cg07537917 chr2:241836409 C2orf54 -0.24 -5.05 -0.3 8.05e-7 Urinary metabolites; CESC cis rs9303280 0.901 rs12936231 chr17:38029120 C/G cg20243544 chr17:37824526 PNMT 0.51 6.87 0.39 4.62e-11 Self-reported allergy; CESC cis rs8014204 1.000 rs8014374 chr14:75322914 G/A cg11812906 chr14:75593930 NEK9 -0.41 -5.12 -0.3 5.88e-7 Caffeine consumption; CESC cis rs12893668 0.542 rs12884809 chr14:104095320 G/A cg24130564 chr14:104152367 KLC1 -0.5 -6.57 -0.37 2.6200000000000003e-10 Reticulocyte count; CESC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg18876405 chr7:65276391 NA -0.5 -6.92 -0.39 3.49e-11 Aortic root size; CESC cis rs10876993 0.784 rs7314152 chr12:58017701 T/G cg18357645 chr12:58087776 OS9 -0.58 -8.84 -0.48 1.38e-16 Celiac disease or Rheumatoid arthritis; CESC cis rs910316 1.000 rs175449 chr14:75590846 A/T cg16144293 chr14:75469539 EIF2B2 0.39 5.18 0.3 4.44e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02339682 chr6:56819432 DST;BEND6 0.53 6.43 0.37 5.96e-10 Gut microbiome composition (summer); CESC cis rs9457247 0.663 rs9459839 chr6:167431829 T/C cg23791538 chr6:167370224 RNASET2 -0.54 -7.33 -0.41 2.81e-12 Crohn's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06790275 chr15:68346669 PIAS1 0.5 6.75 0.38 9.13e-11 Gut microbiota (bacterial taxa); CESC cis rs10463316 0.894 rs6579875 chr5:150782574 C/T cg03212797 chr5:150827313 SLC36A1 -0.42 -5.07 -0.3 7.6e-7 Metabolite levels (Pyroglutamine); CESC cis rs290268 0.874 rs290997 chr9:93559351 G/A cg02608019 chr9:93564028 SYK 0.67 10.21 0.53 7.53e-21 Platelet count; CESC cis rs17807624 0.780 rs11250152 chr8:11454200 A/C cg21775007 chr8:11205619 TDH -0.37 -5.17 -0.3 4.52e-7 Systemic lupus erythematosus; CESC cis rs3011225 0.710 rs3011224 chr1:44318483 C/T cg12908607 chr1:44402522 ARTN -0.46 -6.64 -0.38 1.72e-10 Amyotrophic lateral sclerosis (age of onset); CESC cis rs1371867 0.555 rs2861348 chr8:101285074 A/G cg11906718 chr8:101322791 RNF19A 0.43 5.45 0.32 1.17e-7 Atrioventricular conduction; CESC cis rs2228479 0.850 rs12598316 chr16:89916600 C/A cg00800038 chr16:89945340 TCF25 -0.9 -6.8 -0.39 6.83e-11 Skin colour saturation; CESC cis rs3087591 1.000 rs9902427 chr17:29625430 G/A cg24425628 chr17:29625626 OMG;NF1 -0.46 -5.86 -0.34 1.34e-8 Hip circumference; CESC cis rs727505 0.865 rs17325193 chr7:124648385 A/G cg23710748 chr7:124431027 NA -0.45 -6.98 -0.39 2.31e-11 Lewy body disease; CESC cis rs6831352 0.918 rs7669636 chr4:100059312 G/A cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs4253772 0.591 rs6007727 chr22:46650959 G/A cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.48 5.11 0.3 6.16e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4704187 0.663 rs1422697 chr5:74445817 G/A cg03227963 chr5:74354835 NA 0.3 5.67 0.33 3.76e-8 Response to amphetamines; CESC cis rs7918232 0.882 rs10829190 chr10:27409555 C/T cg14442939 chr10:27389572 ANKRD26 0.67 6.77 0.38 8.28e-11 Breast cancer; CESC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg04369109 chr6:150039330 LATS1 -0.46 -6.29 -0.36 1.29e-9 Lung cancer; CESC cis rs8180040 0.764 rs11130115 chr3:47181661 C/A cg27129171 chr3:47204927 SETD2 0.7 10.6 0.55 4.18e-22 Colorectal cancer; CESC trans rs10489896 0.541 rs2065143 chr1:234568613 T/C cg10395685 chr11:86085715 CCDC81 -0.42 -6.13 -0.35 3.19e-9 Cognitive test performance; CESC cis rs1080500 1.000 rs1080500 chr3:53175017 C/T cg07507251 chr3:52567010 NT5DC2 0.35 5.63 0.33 4.6e-8 Autism spectrum disorder or schizophrenia; CESC cis rs1878931 0.597 rs37814 chr16:3455247 C/T cg02880119 chr16:3481970 NA 0.42 5.24 0.31 3.31e-7 Body mass index (adult); CESC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg11905131 chr22:24372483 LOC391322 -0.79 -11.76 -0.59 5.75e-26 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs13106227 0.550 rs13146564 chr4:77376636 C/A cg20311846 chr4:77356250 SHROOM3 -0.31 -5.67 -0.33 3.69e-8 Eosinophilic esophagitis (pediatric); CESC cis rs1448094 0.791 rs11117122 chr12:86337749 A/C cg02569458 chr12:86230093 RASSF9 0.45 6.34 0.36 9.64e-10 Major depressive disorder; CESC cis rs9811920 0.809 rs4928150 chr3:99685991 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.43 5.71 0.33 3.06e-8 Axial length; CESC cis rs472109 1.000 rs93138 chr11:9759713 A/C cg03108697 chr11:9732066 SWAP70 -0.34 -5.17 -0.3 4.68e-7 Coronary artery disease; CESC cis rs12476592 0.602 rs1356390 chr2:63669625 C/T cg17519650 chr2:63277830 OTX1 0.46 5.18 0.3 4.36e-7 Childhood ear infection; CESC cis rs7615952 0.932 rs1976458 chr3:125647512 T/G cg05084668 chr3:125655381 ALG1L -0.51 -5.95 -0.34 8.56e-9 Blood pressure (smoking interaction); CESC cis rs12148488 0.738 rs4886417 chr15:75330159 T/G cg09165964 chr15:75287851 SCAMP5 0.6 8.08 0.44 2.24e-14 Caffeine consumption; CESC cis rs7771547 0.573 rs546353 chr6:36398597 C/A cg04289385 chr6:36355825 ETV7 0.38 5.57 0.32 6.41e-8 Platelet distribution width; CESC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg27286337 chr10:134555280 INPP5A 0.68 7.69 0.43 2.9e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7666738 0.830 rs13147195 chr4:98893334 G/T cg17366294 chr4:99064904 C4orf37 0.55 7.51 0.42 9.34e-13 Colonoscopy-negative controls vs population controls; CESC cis rs9814567 1.000 rs4423809 chr3:134300107 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.44 6.0 0.35 6.44e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9354308 0.933 rs1938068 chr6:66607807 T/C cg07460842 chr6:66804631 NA 0.65 7.38 0.41 2.04e-12 Metabolite levels; CESC cis rs116095464 0.764 rs10069197 chr5:230822 G/C cg10591111 chr5:226296 SDHA -0.54 -6.65 -0.38 1.72e-10 Breast cancer; CESC cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg21399703 chr1:247681439 NA 0.55 7.37 0.41 2.13e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs7847628 0.765 rs7026635 chr9:123550027 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.52 -6.05 -0.35 4.95e-9 Birth weight; CESC cis rs7116495 1.000 rs482013 chr11:71803962 G/A cg26138937 chr11:71823887 C11orf51 -0.86 -7.03 -0.4 1.75e-11 Severe influenza A (H1N1) infection; CESC cis rs4237845 0.537 rs12426201 chr12:58259752 C/T cg02175503 chr12:58329896 NA 0.48 5.75 0.33 2.42e-8 Intelligence (multi-trait analysis); CESC cis rs7296418 0.738 rs1568428 chr12:123738876 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.32 5.22 0.31 3.63e-7 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08292968 chr12:111020671 PPTC7 0.61 7.55 0.42 7.05e-13 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg22920501 chr2:26401640 FAM59B -0.68 -8.22 -0.45 9.31e-15 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg12963246 chr6:28129442 ZNF389 -0.59 -8.2 -0.45 1.02e-14 Depression; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg17269277 chr4:1796142 FGFR3 0.47 6.05 0.35 5e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9549367 0.789 rs3794422 chr13:113893729 G/A cg18105134 chr13:113819100 PROZ -0.69 -8.42 -0.46 2.39e-15 Platelet distribution width; CESC cis rs9549367 0.713 rs4907599 chr13:113861441 C/T cg18105134 chr13:113819100 PROZ 0.54 7.03 0.4 1.73e-11 Platelet distribution width; CESC cis rs3749237 0.595 rs11130196 chr3:49490149 A/C cg06212747 chr3:49208901 KLHDC8B 0.52 6.98 0.39 2.35e-11 Resting heart rate; CESC cis rs7208859 0.524 rs57670615 chr17:29069498 A/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6089829 0.925 rs4809270 chr20:61676709 C/A cg08564027 chr20:61660810 NA 0.91 14.59 0.67 8.57e-36 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02330394 chr6:10695063 C6orf52;PAK1IP1 0.54 6.01 0.35 6.04e-9 Gut microbiome composition (summer); CESC cis rs763121 0.819 rs5757161 chr22:38990662 G/A cg06544989 chr22:39130855 UNC84B 0.52 9.51 0.5 1.23e-18 Menopause (age at onset); CESC cis rs9470366 0.816 rs1321310 chr6:36623124 C/T cg08179530 chr6:36648295 CDKN1A -0.52 -6.16 -0.35 2.75e-9 QRS duration; CESC cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.850 rs62056069 chr16:89912000 C/T cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs72901758 0.768 rs72901762 chr17:76244926 A/G cg25512537 chr17:76250053 NA 0.37 5.23 0.31 3.41e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs9905704 0.918 rs369184 chr17:56709086 C/T cg12560992 chr17:57184187 TRIM37 0.59 7.05 0.4 1.52e-11 Testicular germ cell tumor; CESC cis rs4319547 0.695 rs10846746 chr12:122868696 C/T cg05707623 chr12:122985044 ZCCHC8 0.55 6.22 0.36 1.89e-9 Body mass index; CESC cis rs11098499 0.863 rs10030660 chr4:120436704 G/A cg09307838 chr4:120376055 NA 0.93 12.69 0.61 3.78e-29 Corneal astigmatism; CESC cis rs754466 0.580 rs2579176 chr10:79529350 A/G cg17075019 chr10:79541650 NA -0.84 -12.78 -0.62 1.79e-29 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1784581 0.588 rs6415086 chr6:162418147 C/T cg17173639 chr6:162384350 PARK2 0.56 8.62 0.47 6.34e-16 Itch intensity from mosquito bite; CESC cis rs1707322 1.000 rs7517560 chr1:46425943 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2777491 0.915 rs7178634 chr15:41634587 A/G cg02330683 chr15:41787940 ITPKA 0.44 6.51 0.37 3.74e-10 Ulcerative colitis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21638108 chr19:19431283 KIAA0892;SF4 -0.47 -6.27 -0.36 1.43e-9 Ulcerative colitis; CESC cis rs2243480 1.000 rs34703416 chr7:65300642 A/G cg25894440 chr7:65020034 NA -0.6 -5.35 -0.31 1.86e-7 Diabetic kidney disease; CESC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg11764359 chr7:65958608 NA -0.67 -8.59 -0.47 7.69e-16 Calcium levels; CESC cis rs12364620 1 rs12364620 chr11:68252123 T/G cg20283391 chr11:68216788 NA -0.64 -7.81 -0.43 1.36e-13 Total body bone mineral density (age 0-15); CESC cis rs193541 0.593 rs154517 chr5:122189825 A/T cg19412675 chr5:122181750 SNX24 0.46 5.47 0.32 1.05e-7 Glucose homeostasis traits; CESC cis rs11190604 1.000 rs9419897 chr10:102246125 T/C cg07080220 chr10:102295463 HIF1AN 0.55 5.38 0.31 1.6e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg19257562 chr1:2043853 PRKCZ 0.38 6.14 0.35 2.93e-9 Height; CESC cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg17366294 chr4:99064904 C4orf37 0.58 8.32 0.46 4.54e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2841277 0.676 rs10438247 chr14:105411781 G/A cg17340268 chr14:105411764 AHNAK2 -0.52 -7.04 -0.4 1.6e-11 Rheumatoid arthritis; CESC cis rs9300255 0.679 rs28583837 chr12:123863620 G/A cg19016782 chr12:123741754 C12orf65 0.44 5.4 0.31 1.48e-7 Neutrophil percentage of white cells; CESC cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg00475322 chr7:917719 C7orf20 0.47 7.04 0.4 1.67e-11 Perceived unattractiveness to mosquitoes; CESC trans rs4942242 0.663 rs7332737 chr13:44215043 C/T cg19169023 chr15:41853346 TYRO3 -0.63 -7.93 -0.44 6.13e-14 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.5 0.32 8.74e-8 Personality dimensions; CESC cis rs16867321 0.694 rs721301 chr2:181387265 A/G cg23363182 chr2:181467187 NA 0.48 6.84 0.39 5.61e-11 Obesity; CESC cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -9.47 -0.5 1.6e-18 Extrinsic epigenetic age acceleration; CESC cis rs614226 0.938 rs12857 chr12:120933946 T/G cg01236616 chr12:121019343 POP5 1.45 17.59 0.73 2.08e-46 Type 1 diabetes nephropathy; CESC cis rs7923452 0.938 rs753173 chr10:30778738 T/C cg18806716 chr10:30721971 MAP3K8 0.49 5.88 0.34 1.22e-8 Itch intensity from mosquito bite; CESC cis rs2204008 0.837 rs10876019 chr12:37985477 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.84 0.55 6.46e-23 Bladder cancer; CESC cis rs6964587 0.839 rs11767135 chr7:91551245 T/G cg01689657 chr7:91764605 CYP51A1 -0.29 -5.17 -0.3 4.57e-7 Breast cancer; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg18827097 chr2:3522506 ADI1 0.49 6.3 0.36 1.26e-9 Tetralogy of Fallot; CESC cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg05347473 chr6:146136440 FBXO30 0.58 7.55 0.42 6.97e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg20243544 chr17:37824526 PNMT -0.49 -6.09 -0.35 3.9e-9 Glomerular filtration rate (creatinine); CESC cis rs2228479 1.000 rs2228479 chr16:89985940 G/A cg14709524 chr16:89940631 TCF25 0.85 6.06 0.35 4.62e-9 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10932289 chr17:55038442 COIL 0.62 6.53 0.37 3.28e-10 Gut microbiome composition (summer); CESC cis rs9943753 0.525 rs983307 chr12:109815103 T/G cg19025524 chr12:109796872 NA -0.47 -6.7 -0.38 1.23e-10 HDL cholesterol; CESC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg11764359 chr7:65958608 NA 0.78 11.31 0.57 1.86e-24 Aortic root size; CESC cis rs9039 0.918 rs12933086 chr16:9225494 A/G cg08831531 chr16:9218945 NA -0.57 -7.22 -0.41 5.66e-12 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24361620 chr11:45868787 CRY2 0.49 6.43 0.37 5.97e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs453301 0.682 rs2929308 chr8:9084121 T/A cg06636001 chr8:8085503 FLJ10661 -0.55 -7.28 -0.41 3.8e-12 Joint mobility (Beighton score); CESC cis rs1538970 0.816 rs4633317 chr1:45985157 T/C cg05343316 chr1:45956843 TESK2 0.92 12.59 0.61 8.59e-29 Platelet count; CESC cis rs3020736 0.500 rs764481 chr22:42518426 G/A cg04733989 chr22:42467013 NAGA -0.78 -11.9 -0.59 1.87e-26 Autism spectrum disorder or schizophrenia; CESC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 11.96 0.59 1.2e-26 Alzheimer's disease; CESC cis rs933688 1.000 rs10073657 chr5:90689749 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 16.88 0.72 6.87e-44 Smoking behavior; CESC cis rs1843834 0.539 rs2068244 chr2:225440011 A/G cg22455342 chr2:225449267 CUL3 -0.69 -8.31 -0.45 4.86e-15 IgE levels in asthmatics (D.p. specific); CESC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg06873352 chr17:61820015 STRADA 0.72 12.85 0.62 1.03e-29 Prudent dietary pattern; CESC trans rs9929218 1.000 rs35069703 chr16:68789445 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.7 -8.68 -0.47 4.11e-16 Colorectal cancer; CESC cis rs4849845 0.612 rs3806491 chr2:121008675 G/A cg24070213 chr2:121070622 NA 0.44 6.39 0.37 7.34e-10 Mean platelet volume; CESC cis rs881375 0.715 rs7858209 chr9:123645760 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.99 0.39 2.29e-11 Rheumatoid arthritis; CESC cis rs12079745 0.793 rs12062884 chr1:169209513 G/A cg09363564 chr1:169337483 NME7;BLZF1 -1.03 -6.33 -0.36 1.04e-9 QT interval; CESC cis rs2629540 0.882 rs10901813 chr10:126429875 G/A cg08799069 chr10:126477246 METTL10 -0.69 -9.3 -0.5 5.47e-18 Cocaine dependence; CESC cis rs854765 0.583 rs7213225 chr17:17869111 T/C cg04398451 chr17:18023971 MYO15A -0.7 -9.85 -0.52 1.04e-19 Total body bone mineral density; CESC cis rs787274 1.000 rs7868830 chr9:115577125 G/A cg13803584 chr9:115635662 SNX30 -0.59 -5.16 -0.3 4.75e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg04025307 chr7:1156635 C7orf50 0.46 6.29 0.36 1.3e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg22535103 chr8:58192502 C8orf71 -0.67 -7.19 -0.4 6.53e-12 Developmental language disorder (linguistic errors); CESC cis rs11252926 1.000 rs11252926 chr10:566379 C/T cg08603382 chr10:743973 NA -0.6 -7.68 -0.43 3.07e-13 Psychosis in Alzheimer's disease; CESC cis rs4704187 0.687 rs10462512 chr5:74387317 C/G cg03227963 chr5:74354835 NA 0.32 5.92 0.34 9.97e-9 Response to amphetamines; CESC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg27170947 chr2:26402098 FAM59B -0.59 -7.02 -0.4 1.84e-11 Gut microbiome composition (summer); CESC cis rs2486288 0.656 rs11854325 chr15:45548959 T/C cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.54 -0.37 3.21e-10 Glomerular filtration rate; CESC cis rs7193541 0.682 rs28681530 chr16:74682496 C/T cg01733217 chr16:74700730 RFWD3 1.05 20.16 0.78 2e-55 Multiple myeloma; CESC trans rs629535 0.911 rs490165 chr8:70014976 A/G cg21567404 chr3:27674614 NA -0.89 -10.79 -0.55 9.77e-23 Dupuytren's disease; CESC cis rs910316 0.737 rs175424 chr14:75626257 T/C cg08847533 chr14:75593920 NEK9 -0.87 -14.36 -0.66 5.69e-35 Height; CESC cis rs6088580 0.634 rs4911152 chr20:32955024 T/C cg06115741 chr20:33292138 TP53INP2 -0.45 -5.81 -0.34 1.75e-8 Glomerular filtration rate (creatinine); CESC cis rs34779708 0.897 rs4934527 chr10:35281118 T/A cg03585969 chr10:35415529 CREM 0.77 10.32 0.54 3.18e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs1018836 0.575 rs17635255 chr8:91518135 A/T cg16814680 chr8:91681699 NA -0.56 -6.5 -0.37 4.01e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9916302 0.851 rs9904919 chr17:37556431 G/C cg15445000 chr17:37608096 MED1 -0.39 -6.44 -0.37 5.69e-10 Glomerular filtration rate (creatinine); CESC cis rs7044106 0.708 rs991121 chr9:123370345 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 9.82 0.52 1.32e-19 Hip circumference adjusted for BMI; CESC cis rs4905014 1.000 rs4905014 chr14:93412031 C/G cg21097788 chr14:93502930 ITPK1 0.7 5.53 0.32 7.61e-8 Age-related diseases and mortality;Age-related diseases, mortality and associated endophenotypes; CESC cis rs7726839 0.540 rs61731455 chr5:665295 A/G cg09021430 chr5:549028 NA -0.42 -5.16 -0.3 4.75e-7 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02322435 chr11:67815326 TCIRG1 0.55 7.58 0.42 5.77e-13 Fibrinogen levels; CESC cis rs8060686 0.641 rs111227007 chr16:68093138 T/A cg26727032 chr16:67993705 SLC12A4 -0.55 -6.15 -0.35 2.9e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs35110281 0.837 rs2838336 chr21:45071741 A/G cg04455712 chr21:45112962 RRP1B -0.41 -6.22 -0.36 1.98e-9 Mean corpuscular volume; CESC cis rs9905704 0.874 rs304265 chr17:56749298 C/T cg12560992 chr17:57184187 TRIM37 0.58 6.94 0.39 3.01e-11 Testicular germ cell tumor; CESC cis rs116095464 0.558 rs10036253 chr5:238519 A/C cg10591111 chr5:226296 SDHA -0.52 -6.32 -0.36 1.1e-9 Breast cancer; CESC cis rs11098499 0.954 rs13113483 chr4:120309039 C/T cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs916888 0.821 rs70600 chr17:44860021 C/T cg15921436 chr17:44337874 NA 0.69 7.29 0.41 3.52e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4233802 0.708 rs7564743 chr2:151133831 A/G cg25300694 chr2:151184358 NA 0.9 7.32 0.41 3.03e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs6499255 1.000 rs4985518 chr16:69787158 T/C cg15192750 chr16:69999425 NA 0.44 5.36 0.31 1.84e-7 IgE levels; CESC cis rs7089973 0.604 rs58587374 chr10:116597572 A/G cg23260525 chr10:116636907 FAM160B1 0.4 7.38 0.41 2.03e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9640161 0.783 rs1132261 chr7:150059987 G/A cg21361702 chr7:150065534 REPIN1 0.69 8.31 0.45 4.97e-15 Blood protein levels;Circulating chemerin levels; CESC cis rs2549003 0.811 rs10035166 chr5:131823927 C/T cg21138405 chr5:131827807 IRF1 -0.42 -5.83 -0.34 1.62e-8 Asthma (sex interaction); CESC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.32 5.8 0.34 1.92e-8 Electroencephalogram traits; CESC cis rs7208859 0.524 rs59923796 chr17:29064919 G/A cg13385521 chr17:29058706 SUZ12P 0.82 6.62 0.38 2.04e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg20203395 chr5:56204925 C5orf35 0.46 5.66 0.33 3.98e-8 Initial pursuit acceleration; CESC cis rs2046867 0.818 rs6792109 chr3:72867091 C/T cg25664220 chr3:72788482 NA -0.42 -5.95 -0.34 8.45e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.75 8.25 0.45 7.7e-15 Alzheimer's disease; CESC cis rs1865760 0.555 rs2051541 chr6:25945211 C/T cg18357526 chr6:26021779 HIST1H4A -0.38 -5.2 -0.3 4.02e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07624948 chr16:28962847 NFATC2IP -0.62 -7.18 -0.4 6.89e-12 Gut microbiome composition (summer); CESC trans rs629535 0.699 rs539956 chr8:70033647 G/A cg21567404 chr3:27674614 NA 0.93 11.14 0.56 6.62e-24 Dupuytren's disease; CESC cis rs35306767 0.807 rs61831436 chr10:837882 G/A cg10556349 chr10:835070 NA 0.7 6.0 0.35 6.41e-9 Eosinophil percentage of granulocytes; CESC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg04166393 chr7:2884313 GNA12 0.62 8.46 0.46 1.85e-15 Height; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg24511898 chr2:242576823 ATG4B;THAP4 0.47 6.55 0.37 2.97e-10 Systemic lupus erythematosus; CESC cis rs7617773 0.817 rs6800492 chr3:48323890 G/A cg11946769 chr3:48343235 NME6 0.81 10.85 0.55 6.06e-23 Coronary artery disease; CESC cis rs9549260 0.755 rs55920113 chr13:41222112 C/T cg21288729 chr13:41239152 FOXO1 0.65 8.5 0.46 1.4e-15 Red blood cell count; CESC cis rs9549367 0.789 rs2287250 chr13:113889474 C/T cg00898013 chr13:113819073 PROZ 0.48 6.9 0.39 3.72e-11 Platelet distribution width; CESC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg15145296 chr3:125709740 NA -0.45 -5.14 -0.3 5.34e-7 Blood pressure (smoking interaction); CESC trans rs11098499 0.866 rs6824111 chr4:120285968 T/A cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs2361718 0.568 rs1042397 chr17:78092063 G/A cg20811857 chr17:78079795 GAA -0.37 -5.64 -0.33 4.44e-8 Yeast infection; CESC cis rs6665290 0.870 rs17600725 chr1:227204231 A/G cg10327440 chr1:227177885 CDC42BPA -1.17 -25.22 -0.84 2.18e-72 Myeloid white cell count; CESC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.83 0.39 5.96e-11 Bipolar disorder; CESC cis rs8072100 0.656 rs2610367 chr17:45569815 A/G cg25173405 chr17:45401733 C17orf57 -0.41 -5.31 -0.31 2.27e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs10885582 0.904 rs12357781 chr10:116343076 C/T cg17056676 chr10:116301354 ABLIM1 0.3 5.1 0.3 6.45e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg10800226 chr5:1850261 NA 0.31 5.06 0.3 7.76e-7 Cardiovascular disease risk factors; CESC cis rs2242073 0.660 rs6751246 chr2:209002331 T/C cg10392614 chr2:208977121 NA -0.37 -5.04 -0.3 8.79e-7 Attention deficit hyperactivity disorder; CESC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg08704250 chr15:31115839 NA 0.69 9.22 0.49 9.79e-18 Huntington's disease progression; CESC cis rs9796 0.558 rs7166205 chr15:41514733 A/G cg18705301 chr15:41695430 NDUFAF1 -0.47 -7.09 -0.4 1.2e-11 Menopause (age at onset); CESC cis rs8099014 0.859 rs11152072 chr18:56098912 A/G cg19312305 chr18:56117016 MIR122 -0.3 -5.51 -0.32 8.34e-8 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08090396 chr3:52805200 NEK4 -0.59 -6.87 -0.39 4.5e-11 Gut microbiome composition (summer); CESC cis rs2108225 0.934 rs2283045 chr7:107440714 G/A cg18560240 chr7:107437656 SLC26A3 -0.37 -5.08 -0.3 7.01e-7 Ulcerative colitis; CESC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg12463550 chr7:65579703 CRCP -0.48 -6.17 -0.35 2.6e-9 Aortic root size; CESC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg04267008 chr7:1944627 MAD1L1 -0.58 -6.9 -0.39 3.75e-11 Bipolar disorder and schizophrenia; CESC cis rs35306767 0.951 rs55742421 chr10:961037 A/C cg25019033 chr10:957182 NA -0.6 -6.42 -0.37 6.2e-10 Eosinophil percentage of granulocytes; CESC cis rs5769765 0.837 rs4824110 chr22:50271631 T/A cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs3892630 0.824 rs2287882 chr19:33332952 C/T cg22980127 chr19:33182716 NUDT19 0.99 11.18 0.57 5.0600000000000004e-24 Red blood cell traits; CESC cis rs662064 0.890 rs1632108 chr1:10561923 C/T cg20482658 chr1:10539492 PEX14 0.38 7.59 0.42 5.56e-13 Asthma; CESC cis rs6964587 0.626 rs35849169 chr7:91507313 A/G cg17063962 chr7:91808500 NA 0.42 5.92 0.34 9.83e-9 Breast cancer; CESC cis rs17854409 1.000 rs16983290 chr20:61478894 A/G cg05147244 chr20:61493195 TCFL5 -0.99 -7.54 -0.42 7.73e-13 Obesity-related traits; CESC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg26818010 chr10:134567672 INPP5A -0.9 -10.88 -0.56 4.78e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7116495 0.881 rs6592449 chr11:71670222 C/T cg10381502 chr11:71823885 C11orf51 -0.65 -5.54 -0.32 7.21e-8 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18368637 chr6:144179905 LTV1 -0.58 -6.1 -0.35 3.69e-9 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg08888278 chr19:13953225 NA -0.5 -6.87 -0.39 4.63e-11 Asthma; CESC cis rs61776719 0.500 rs11210866 chr1:38449565 T/C cg26398791 chr1:38455867 SF3A3 -0.42 -5.38 -0.31 1.62e-7 Coronary artery disease; CESC cis rs28673728 0.897 rs28391281 chr1:38408974 T/C cg12658694 chr1:38397304 INPP5B 0.64 9.27 0.49 6.76e-18 Red cell distribution width; CESC cis rs2204008 0.744 rs11514358 chr12:38255526 G/A cg13010199 chr12:38710504 ALG10B 0.52 6.38 0.36 8.04e-10 Bladder cancer; CESC cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg02574844 chr11:5959923 NA -0.41 -5.16 -0.3 4.73e-7 DNA methylation (variation); CESC cis rs9549367 0.713 rs556990 chr13:113845059 T/C cg18105134 chr13:113819100 PROZ 0.54 7.05 0.4 1.55e-11 Platelet distribution width; CESC cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.54 -5.57 -0.32 6.18e-8 Schizophrenia; CESC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg02034447 chr16:89574710 SPG7 0.46 5.92 0.34 9.81e-9 Multiple myeloma (IgH translocation); CESC cis rs2637266 0.935 rs4520537 chr10:78392978 C/T cg18941641 chr10:78392320 NA 0.44 8.62 0.47 6.27e-16 Pulmonary function; CESC cis rs10504073 0.584 rs115370638 chr8:49916452 A/G cg00325661 chr8:49890786 NA 0.53 7.95 0.44 5.42e-14 Blood metabolite ratios; CESC cis rs2797160 1.000 rs2747722 chr6:126009629 A/G cg05901451 chr6:126070800 HEY2 0.45 6.59 0.38 2.39e-10 Endometrial cancer; CESC cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs4481887 0.927 rs4282853 chr1:248475127 A/G cg00666640 chr1:248458726 OR2T12 0.36 6.12 0.35 3.33e-9 Common traits (Other); CESC cis rs9300255 0.537 rs1619561 chr12:123620268 G/C cg05973401 chr12:123451056 ABCB9 0.55 6.06 0.35 4.77e-9 Neutrophil percentage of white cells; CESC cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg26116260 chr4:7069785 GRPEL1 0.94 14.36 0.66 5.55e-35 Monocyte percentage of white cells; CESC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21370986 chr7:6145114 USP42 0.58 6.82 0.39 5.98e-11 Gut microbiome composition (summer); CESC cis rs11048434 0.736 rs1805732 chr12:9090892 A/G cg04155231 chr12:9217510 LOC144571 -0.33 -5.22 -0.31 3.57e-7 Sjögren's syndrome; CESC cis rs919433 0.889 rs12472355 chr2:198205840 C/A cg10820045 chr2:198174542 NA -0.39 -5.75 -0.33 2.45e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg05332525 chr7:65337924 VKORC1L1 0.46 5.7 0.33 3.11e-8 Calcium levels; CESC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg19592336 chr6:28129416 ZNF389 0.58 7.71 0.43 2.54e-13 Depression; CESC cis rs1707322 1.000 rs4660336 chr1:46487976 T/C cg06784218 chr1:46089804 CCDC17 -0.32 -5.5 -0.32 8.79e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8114671 0.836 rs6142280 chr20:33622242 A/C cg07148914 chr20:33460835 GGT7 -0.42 -5.41 -0.32 1.44e-7 Height; CESC cis rs7208859 0.623 rs11657990 chr17:29124200 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.13 0.3 5.49e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs2593957 0.503 rs9821382 chr3:108812154 A/G cg17027945 chr15:74284732 STOML1 -0.51 -6.03 -0.35 5.54e-9 Colorectal cancer (diet interaction); CESC cis rs17253792 0.749 rs74979160 chr14:56097568 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg11494091 chr17:61959527 GH2 0.76 13.18 0.63 7.67e-31 Prudent dietary pattern; CESC cis rs9346455 0.614 rs2273888 chr6:72006512 C/T cg27238071 chr6:71998145 OGFRL1 -0.65 -6.35 -0.36 9.44e-10 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg06877462 chr1:205807181 PM20D1 0.39 5.51 0.32 8.43e-8 Menarche (age at onset); CESC cis rs7465272 0.530 rs10103161 chr8:143738571 A/G cg24634471 chr8:143751801 JRK 0.46 5.97 0.34 7.52e-9 Bipolar disorder and schizophrenia; CESC trans rs629535 0.783 rs510632 chr8:70034570 A/G cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs9549367 0.789 rs2302754 chr13:113898385 C/T cg00898013 chr13:113819073 PROZ 0.48 6.55 0.37 3.01e-10 Platelet distribution width; CESC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.96 0.52 4.61e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12824058 0.831 rs11608407 chr12:130805869 G/A cg26677194 chr12:130822605 PIWIL1 0.49 6.24 0.36 1.75e-9 Menopause (age at onset); CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg13917004 chr19:42462874 RABAC1 0.48 6.02 0.35 5.91e-9 Attention deficit hyperactivity disorder; CESC cis rs2243480 0.522 rs1638736 chr7:66092308 A/T cg13147721 chr7:65941812 NA -0.72 -5.92 -0.34 1.02e-8 Diabetic kidney disease; CESC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Depression; CESC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg24531977 chr5:56204891 C5orf35 -0.89 -11.26 -0.57 2.62e-24 Initial pursuit acceleration; CESC cis rs1030268 0.546 rs12707100 chr7:133274376 T/C cg10665199 chr7:133106180 EXOC4 0.51 5.4 0.32 1.45e-7 Intelligence (multi-trait analysis); CESC cis rs8027181 0.839 rs998021 chr15:72999825 T/C cg25632853 chr15:73088954 NA 0.3 5.24 0.31 3.3e-7 Triglyceride levels; CESC cis rs425277 1.000 rs809912 chr1:2078385 C/T cg24578937 chr1:2090814 PRKCZ 0.55 9.54 0.51 9.57e-19 Height; CESC cis rs6089584 0.927 rs6089593 chr20:60572312 G/A cg13770153 chr20:60521292 NA -0.48 -6.35 -0.36 9.54e-10 Body mass index; CESC cis rs9905704 0.507 rs7219031 chr17:56445908 G/A cg12560992 chr17:57184187 TRIM37 0.64 5.49 0.32 9.54e-8 Testicular germ cell tumor; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02895995 chr19:7554069 PEX11G -0.46 -6.92 -0.39 3.41e-11 Gambling; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04117832 chr2:152685230 ARL5A 0.44 6.19 0.36 2.23e-9 Gut microbiota (bacterial taxa); CESC cis rs1023500 0.573 rs2269524 chr22:42475703 T/G cg12850546 chr22:42539477 CYP2D7P1 0.43 5.12 0.3 5.88e-7 Schizophrenia; CESC cis rs7666738 0.546 rs13148080 chr4:98680947 A/G cg17366294 chr4:99064904 C4orf37 0.47 5.82 0.34 1.68e-8 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20646217 chr22:21356059 FLJ39582;THAP7 -0.45 -6.46 -0.37 5.13e-10 Gambling; CESC cis rs6942756 0.806 rs7794622 chr7:128996268 T/C cg02491457 chr7:128862824 NA -0.6 -8.46 -0.46 1.78e-15 White matter hyperintensity burden; CESC cis rs2228479 0.850 rs11649100 chr16:89798179 A/G cg06558623 chr16:89946397 TCF25 1.03 7.52 0.42 8.67e-13 Skin colour saturation; CESC cis rs1448094 0.838 rs11834294 chr12:86311958 C/T cg02569458 chr12:86230093 RASSF9 0.36 5.12 0.3 6.01e-7 Major depressive disorder; CESC cis rs4148883 0.689 rs1311621 chr4:100014018 T/C cg13256891 chr4:100009986 ADH5 0.54 7.09 0.4 1.25e-11 Alcohol dependence; CESC cis rs5753618 0.539 rs695438 chr22:31811876 G/C cg13145458 chr22:31556086 RNF185 -0.44 -5.55 -0.32 6.84e-8 Colorectal cancer; CESC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 5.04 0.3 8.54e-7 Calcium levels; CESC cis rs6088590 1.000 rs12626122 chr20:33425800 A/G cg08999081 chr20:33150536 PIGU 0.59 8.58 0.47 8.33e-16 Coronary artery disease; CESC cis rs8092503 1.000 rs7231263 chr18:52493167 A/T cg12377874 chr18:52495404 RAB27B -0.33 -5.73 -0.33 2.66e-8 Childhood body mass index; CESC cis rs7824557 0.603 rs2249804 chr8:11215617 C/G cg21775007 chr8:11205619 TDH 0.54 7.78 0.43 1.62e-13 Retinal vascular caliber; CESC cis rs7927771 0.524 rs7929725 chr11:47881740 A/G cg20307385 chr11:47447363 PSMC3 0.62 8.76 0.47 2.32e-16 Subjective well-being; CESC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.76 0.51 1.99e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9611565 0.722 rs202635 chr22:41809637 C/T cg03806693 chr22:41940476 POLR3H 1.04 12.37 0.61 4.76e-28 Vitiligo; CESC cis rs7044106 0.762 rs10760112 chr9:123467570 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.9 0.34 1.11e-8 Hip circumference adjusted for BMI; CESC cis rs5753618 0.561 rs5753609 chr22:31819212 A/G cg02404636 chr22:31891804 SFI1 0.44 6.29 0.36 1.31e-9 Colorectal cancer; CESC cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg18512352 chr11:47633146 NA -0.51 -7.43 -0.42 1.46e-12 Subjective well-being; CESC cis rs6496667 0.509 rs2657948 chr15:90948617 G/A cg22089800 chr15:90895588 ZNF774 0.44 5.63 0.33 4.48e-8 Rheumatoid arthritis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg18679886 chr7:107531975 DLD -0.49 -6.59 -0.38 2.34e-10 Height; CESC cis rs13064411 0.696 rs7619913 chr3:113017503 A/G cg18753928 chr3:113234510 CCDC52 -0.49 -5.07 -0.3 7.62e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs7927771 0.832 rs10838697 chr11:47384484 T/A cg20307385 chr11:47447363 PSMC3 -0.61 -7.21 -0.41 5.76e-12 Subjective well-being; CESC cis rs863345 0.584 rs1117125 chr1:158509396 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -7.04 -0.4 1.68e-11 Pneumococcal bacteremia; CESC cis rs9532580 0.656 rs2721068 chr13:41139712 T/C cg21288729 chr13:41239152 FOXO1 0.67 7.9 0.44 7.34e-14 Mean corpuscular hemoglobin; CESC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg13206674 chr6:150067644 NUP43 0.42 5.88 0.34 1.21e-8 Lung cancer; CESC cis rs2051211 1.000 rs17037804 chr3:38559215 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.57 -7.14 -0.4 8.97e-12 QRS duration; CESC cis rs763121 0.719 rs9610995 chr22:39057763 C/T cg06544989 chr22:39130855 UNC84B 0.49 8.49 0.46 1.53e-15 Menopause (age at onset); CESC cis rs7843479 0.898 rs4311656 chr8:21802276 T/G cg17168535 chr8:21777572 XPO7 0.5 6.87 0.39 4.48e-11 Mean corpuscular volume; CESC cis rs13256369 0.950 rs13255655 chr8:8577736 C/T cg00074818 chr8:8560427 CLDN23 0.42 6.01 0.35 6.24e-9 Obesity-related traits; CESC cis rs6456156 0.586 rs7761977 chr6:167485678 A/G cg07741184 chr6:167504864 NA 0.37 6.28 0.36 1.39e-9 Primary biliary cholangitis; CESC cis rs6690583 1.000 rs10443172 chr1:85485768 T/C cg22153463 chr1:85462885 MCOLN2 -0.74 -8.69 -0.47 3.76e-16 Serum sulfate level; CESC cis rs34779708 0.931 rs12776390 chr10:35391535 T/G cg03585969 chr10:35415529 CREM 0.78 10.4 0.54 1.88e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg20790798 chr5:1857306 NA -0.4 -5.42 -0.32 1.37e-7 Cardiovascular disease risk factors; CESC cis rs2204008 0.693 rs12372025 chr12:38202028 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.75 0.38 9.46e-11 Bladder cancer; CESC cis rs2011503 0.882 rs2060276 chr19:19522491 T/G cg11584989 chr19:19387371 SF4 0.62 6.86 0.39 4.74e-11 Bipolar disorder; CESC cis rs2070488 0.775 rs762318 chr3:38516369 C/A cg24069376 chr3:38537580 EXOG 0.36 6.09 0.35 4.02e-9 Electrocardiographic conduction measures; CESC trans rs1005277 0.579 rs1780146 chr10:38517874 C/A cg27523141 chr10:43048294 ZNF37B 0.46 6.01 0.35 6.19e-9 Extrinsic epigenetic age acceleration; CESC cis rs10791097 0.547 rs12365680 chr11:130749059 C/T cg14779329 chr11:130786720 SNX19 0.32 5.04 0.3 8.7e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7927771 1.000 rs4752857 chr11:47655752 C/T cg18512352 chr11:47633146 NA -0.61 -9.7 -0.51 3.19e-19 Subjective well-being; CESC cis rs3796352 1.000 rs34244302 chr3:53102236 C/G cg12962167 chr3:53033115 SFMBT1 0.7 6.17 0.35 2.6e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs300703 0.935 rs10167992 chr2:263270 C/T cg21211680 chr2:198530 NA -0.77 -6.89 -0.39 4.04e-11 Blood protein levels; CESC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg05368731 chr17:41323189 NBR1 0.78 10.62 0.55 3.59e-22 Menopause (age at onset); CESC cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.8 0.48 1.79e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7223966 1.000 rs16947005 chr17:61702989 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.55 -6.54 -0.37 3.07e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7020830 0.898 rs13289199 chr9:37278064 A/T cg14294708 chr9:37120828 ZCCHC7 1.12 18.93 0.76 3.96e-51 Schizophrenia; CESC cis rs4727027 0.800 rs12530946 chr7:148887942 A/G cg23583168 chr7:148888333 NA -0.94 -17.34 -0.73 1.57e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1843834 0.505 rs2140508 chr2:225355839 G/T cg22455342 chr2:225449267 CUL3 0.72 9.92 0.52 6.31e-20 IgE levels in asthmatics (D.p. specific); CESC cis rs6460942 1.000 rs73053527 chr7:12313008 C/A cg10578991 chr7:12443926 VWDE -0.61 -6.41 -0.37 6.66e-10 Coronary artery disease; CESC cis rs11250464 0.833 rs4554799 chr10:1407728 C/T cg26394196 chr10:1453818 ADARB2 -0.45 -6.01 -0.35 6.13e-9 Radiation response; CESC cis rs858239 0.600 rs13438179 chr7:23143851 T/C cg23682824 chr7:23144976 KLHL7 0.54 7.7 0.43 2.68e-13 Cerebrospinal fluid biomarker levels; CESC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs7267979 0.844 rs8184820 chr20:25250577 C/T cg08601574 chr20:25228251 PYGB -0.41 -5.81 -0.34 1.81e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs4704187 0.687 rs4324655 chr5:74373360 C/T cg03227963 chr5:74354835 NA 0.31 5.81 0.34 1.74e-8 Response to amphetamines; CESC cis rs1595825 0.891 rs4491721 chr2:198521407 C/G cg10820045 chr2:198174542 NA 0.41 5.21 0.3 3.79e-7 Ulcerative colitis; CESC cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg00409905 chr10:38381863 ZNF37A -0.45 -6.0 -0.35 6.61e-9 Extrinsic epigenetic age acceleration; CESC cis rs35123781 0.696 rs13154510 chr5:139071301 A/C cg10513866 chr5:139070639 NA 0.45 6.43 0.37 6e-10 Schizophrenia; CESC cis rs9660992 0.573 rs12125276 chr1:205199440 C/T cg00857998 chr1:205179979 DSTYK 0.56 6.88 0.39 4.29e-11 Mean corpuscular volume;Mean platelet volume; CESC trans rs637571 0.584 rs7107912 chr11:65603252 G/A cg17712092 chr4:129076599 LARP1B -0.64 -8.07 -0.44 2.51e-14 Eosinophil percentage of white cells; CESC cis rs11969893 0.850 rs9498418 chr6:101331838 A/T cg12253828 chr6:101329408 ASCC3 0.91 7.44 0.42 1.39e-12 Economic and political preferences (immigration/crime); CESC cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg04234412 chr22:24373322 LOC391322 0.65 8.91 0.48 8.33e-17 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.57 -0.32 6.2e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs6120849 0.901 rs6088735 chr20:33745676 C/T cg24642439 chr20:33292090 TP53INP2 0.6 6.4 0.37 7.09e-10 Protein C levels; CESC cis rs2072732 0.861 rs72629498 chr1:2954203 C/T cg15211996 chr1:2936768 ACTRT2 0.35 5.63 0.33 4.51e-8 Plateletcrit; CESC cis rs2070677 0.935 rs2864985 chr10:135348757 C/G cg20169779 chr10:135381914 SYCE1 0.7 8.08 0.44 2.34e-14 Gout; CESC cis rs1577917 0.917 rs35283633 chr6:86690787 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -5.95 -0.34 8.41e-9 Response to antipsychotic treatment; CESC cis rs6867032 1.000 rs4975794 chr5:2015330 A/G cg26168224 chr5:2018326 NA -0.94 -18.51 -0.75 1.13e-49 Gut microbiome composition (winter); CESC cis rs7621025 0.505 rs13063893 chr3:136387638 C/T cg15507776 chr3:136538369 TMEM22 -0.81 -7.32 -0.41 2.99e-12 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs7248779 1.000 rs7248779 chr19:2403564 G/T cg22729335 chr19:2427816 TIMM13 -0.5 -7.07 -0.4 1.34e-11 Cortisol levels (saliva); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08836619 chr5:139555389 C5orf32 -0.64 -6.91 -0.39 3.66e-11 Gut microbiome composition (summer); CESC cis rs4889855 0.505 rs7501740 chr17:78610345 A/G cg16591659 chr17:78472290 NA -0.34 -5.49 -0.32 9.53e-8 Fractional excretion of uric acid; CESC cis rs36051895 0.632 rs10815166 chr9:5149920 T/G cg02405213 chr9:5042618 JAK2 -0.51 -6.4 -0.37 6.99e-10 Pediatric autoimmune diseases; CESC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg13206674 chr6:150067644 NUP43 -0.41 -5.78 -0.33 2.07e-8 Lung cancer; CESC cis rs6912958 0.712 rs2754262 chr6:88405585 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -5.32 -0.31 2.17e-7 Monocyte percentage of white cells; CESC cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg22509189 chr2:225307070 NA -0.41 -5.52 -0.32 8e-8 IgE levels in asthmatics (D.p. specific); CESC cis rs7267979 0.808 rs84816 chr20:25459919 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.72 12.81 0.62 1.44e-29 Liver enzyme levels (alkaline phosphatase); CESC cis rs1788820 0.917 rs1788760 chr18:21137442 A/G cg14672496 chr18:21087552 C18orf8 0.56 7.62 0.42 4.43e-13 Body mass index; CESC cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg03467027 chr4:99064603 C4orf37 0.44 5.48 0.32 9.97e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4704187 0.687 rs1600074 chr5:74436574 C/T cg03227963 chr5:74354835 NA 0.3 5.55 0.32 6.82e-8 Response to amphetamines; CESC cis rs3820068 0.580 rs12760698 chr1:16009814 G/A cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.5e-7 Systolic blood pressure; CESC cis rs57221529 0.766 rs72706608 chr5:559203 C/T cg09021430 chr5:549028 NA -0.42 -5.26 -0.31 2.92e-7 Lung disease severity in cystic fibrosis; CESC cis rs11098499 0.779 rs10016060 chr4:120298412 A/G cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg16339924 chr4:17578868 LAP3 0.82 10.38 0.54 2.06e-21 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs642803 0.933 rs644740 chr11:65561468 C/T cg10518572 chr11:65560635 OVOL1 0.3 6.44 0.37 5.51e-10 Urate levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18632100 chr19:59028615 ZBTB45 -0.61 -6.62 -0.38 2.01e-10 Gut microbiome composition (summer); CESC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg05315796 chr3:52349193 DNAH1 0.36 5.31 0.31 2.28e-7 Bipolar disorder; CESC cis rs1670533 1.000 rs4690212 chr4:1054898 T/C cg04106633 chr4:1044584 NA 0.41 5.19 0.3 4.11e-7 Recombination rate (females); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20021244 chr5:139944115 APBB3;SLC35A4 -0.46 -6.22 -0.36 1.94e-9 Asthma; CESC cis rs96067 0.643 rs274133 chr1:36581792 G/A cg27506609 chr1:36549197 TEKT2 -0.37 -5.7 -0.33 3.22e-8 Corneal structure; CESC cis rs10088262 0.629 rs1367829 chr8:124797135 A/G cg20713898 chr8:124780851 FAM91A1 -0.67 -9.11 -0.49 2.02e-17 Pancreatic cancer; CESC cis rs362272 0.524 rs2857982 chr4:3358665 G/A cg14583973 chr4:3374767 RGS12 0.32 5.58 0.32 5.85e-8 Serum sulfate level; CESC cis rs9796 0.727 rs61203391 chr15:41352912 C/G cg18705301 chr15:41695430 NDUFAF1 -0.4 -5.83 -0.34 1.58e-8 Menopause (age at onset); CESC cis rs7124681 0.584 rs1471712 chr11:47912150 G/A cg20307385 chr11:47447363 PSMC3 -0.57 -7.98 -0.44 4.46e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs1144333 1.000 rs1340684 chr1:76471146 T/C cg10523679 chr1:76189770 ACADM 0.58 5.36 0.31 1.8e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg11742103 chr11:62369870 EML3;MTA2 0.66 9.86 0.52 9.55e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs13385 0.769 rs34266577 chr5:139547797 C/T cg26211634 chr5:139558579 C5orf32 0.47 5.16 0.3 4.77e-7 Atrial fibrillation; CESC cis rs734999 0.505 rs10910107 chr1:2539181 C/T cg18854424 chr1:2615690 NA 0.3 6.01 0.35 6.23e-9 Ulcerative colitis; CESC cis rs6963495 0.818 rs73190158 chr7:105153943 T/C cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15239874 chr12:121148841 UNC119B 0.47 6.02 0.35 5.75e-9 Gut microbiota (bacterial taxa); CESC cis rs813218 0.625 rs793484 chr3:99491508 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.33 -5.44 -0.32 1.2e-7 Orofacial clefts; CESC cis rs2249694 0.509 rs9419072 chr10:135310445 G/A cg20169779 chr10:135381914 SYCE1 0.41 5.42 0.32 1.36e-7 Obesity-related traits; CESC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg03709012 chr19:19516395 GATAD2A -0.96 -14.2 -0.66 2.12e-34 Tonsillectomy; CESC cis rs72781680 1.000 rs55982282 chr2:24188128 G/A cg20701182 chr2:24300061 SF3B14 0.71 6.25 0.36 1.59e-9 Lymphocyte counts; CESC cis rs708547 0.957 rs1623306 chr4:57773595 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.66 7.03 0.4 1.74e-11 Response to bleomycin (chromatid breaks); CESC trans rs1814175 0.592 rs1794161 chr11:49898825 A/C cg03929089 chr4:120376271 NA -0.9 -14.75 -0.67 2.44e-36 Height; CESC cis rs4481887 0.861 rs7412034 chr1:248434150 G/C cg00666640 chr1:248458726 OR2T12 0.34 5.89 0.34 1.17e-8 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22727761 chr1:24286270 PNRC2 0.55 6.05 0.35 4.96e-9 Gut microbiome composition (summer); CESC cis rs12618769 0.597 rs4850876 chr2:99112069 C/T cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs8072100 0.967 rs7221548 chr17:45582952 T/C cg08085267 chr17:45401833 C17orf57 0.43 5.64 0.33 4.44e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs67478160 0.679 rs7156834 chr14:104211180 G/A cg01849466 chr14:104193079 ZFYVE21 -0.49 -6.87 -0.39 4.47e-11 Schizophrenia; CESC cis rs9300255 0.544 rs1790123 chr12:123659542 C/T cg00376283 chr12:123451042 ABCB9 0.57 6.1 0.35 3.64e-9 Neutrophil percentage of white cells; CESC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg08109568 chr15:31115862 NA -0.71 -9.63 -0.51 5.02e-19 Huntington's disease progression; CESC cis rs7819412 0.740 rs11250119 chr8:11037034 C/T cg21775007 chr8:11205619 TDH -0.35 -5.11 -0.3 6.12e-7 Triglycerides; CESC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg10494973 chr17:80897199 TBCD -0.48 -5.6 -0.33 5.24e-8 Breast cancer; CESC cis rs11098499 0.863 rs6858777 chr4:120475966 A/G cg09307838 chr4:120376055 NA 0.9 12.45 0.61 2.6e-28 Corneal astigmatism; CESC cis rs4689592 0.554 rs3822270 chr4:7069804 C/A cg19539972 chr4:7069911 GRPEL1 0.77 9.72 0.51 2.71e-19 Monocyte percentage of white cells; CESC cis rs10911251 0.528 rs2093982 chr1:183094191 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Colorectal cancer; CESC cis rs11069349 0.608 rs9585056 chr13:100081766 A/G cg25919922 chr13:100150906 NA -0.55 -6.29 -0.36 1.34e-9 Self-reported allergy; CESC cis rs12586317 0.514 rs61100068 chr14:35400232 A/T cg05294307 chr14:35346193 BAZ1A -0.53 -5.34 -0.31 1.99e-7 Psoriasis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18986451 chr3:100428869 TFG 0.44 6.08 0.35 4.14e-9 Systemic lupus erythematosus; CESC cis rs2806561 0.894 rs628106 chr1:23537685 C/T cg12483005 chr1:23474871 LUZP1 0.32 5.15 0.3 4.99e-7 Height; CESC trans rs7937682 0.924 rs10891286 chr11:111532691 C/G cg18187862 chr3:45730750 SACM1L 0.47 6.04 0.35 5.2e-9 Primary sclerosing cholangitis; CESC cis rs7666738 0.830 rs7696715 chr4:98938486 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7605827 0.897 rs7590198 chr2:15536314 C/T cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs400736 0.894 rs225092 chr1:8036075 G/C cg25007680 chr1:8021821 PARK7 0.72 10.31 0.54 3.52e-21 Response to antidepressants and depression; CESC cis rs7216064 1.000 rs6504543 chr17:65837659 T/C cg07042672 chr17:66097459 LOC651250 -0.63 -7.58 -0.42 5.88e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2732480 0.500 rs1552550 chr12:48643351 C/A cg04545296 chr12:48745243 ZNF641 0.39 6.62 0.38 1.99e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs4481887 0.927 rs4336885 chr1:248473168 A/C cg00666640 chr1:248458726 OR2T12 0.36 5.98 0.35 7.04e-9 Common traits (Other); CESC cis rs561341 1.000 rs7216102 chr17:30259450 A/G cg00745463 chr17:30367425 LRRC37B -0.47 -5.24 -0.31 3.26e-7 Hip circumference adjusted for BMI; CESC trans rs7819412 0.540 rs11777355 chr8:11044689 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -6.11 -0.35 3.53e-9 Triglycerides; CESC trans rs1814175 0.935 rs10839329 chr11:49694206 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -17.88 -0.74 1.87e-47 Height; CESC cis rs1348850 0.526 rs10930797 chr2:178437553 C/G cg23306229 chr2:178417860 TTC30B 0.67 5.97 0.34 7.8e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4950322 0.515 rs12060046 chr1:146720934 T/C cg16700924 chr1:146552102 NA -0.39 -5.1 -0.3 6.63e-7 Protein quantitative trait loci; CESC cis rs5758659 1.000 rs5758677 chr22:42643039 A/C cg04733989 chr22:42467013 NAGA 0.42 5.82 0.34 1.67e-8 Cognitive function; CESC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg19468946 chr17:37922297 IKZF3 0.4 5.22 0.31 3.56e-7 Glomerular filtration rate (creatinine); CESC cis rs2228479 1.000 rs4257207 chr16:89947861 T/A cg00800038 chr16:89945340 TCF25 -0.95 -8.0 -0.44 3.92e-14 Skin colour saturation; CESC cis rs12477438 0.520 rs2171359 chr2:99795360 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 15.36 0.69 1.63e-38 Chronic sinus infection; CESC cis rs12586317 0.547 rs28569331 chr14:35473584 T/C cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.45 -7.02 -0.4 1.9e-11 Hemoglobin concentration; CESC cis rs60871478 1.000 rs9195 chr7:825786 C/T cg05535760 chr7:792225 HEATR2 -0.83 -10.54 -0.54 6.23e-22 Cerebrospinal P-tau181p levels; CESC cis rs453301 0.653 rs7016139 chr8:8895470 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -5.79 -0.34 2e-8 Joint mobility (Beighton score); CESC cis rs67311347 1.000 rs7625736 chr3:40441345 C/G cg01475735 chr3:40494733 NA 0.46 6.09 0.35 4.05e-9 Renal cell carcinoma; CESC cis rs4563143 0.675 rs17498203 chr19:29279734 G/T cg14983838 chr19:29218262 NA 0.48 5.62 0.33 4.73e-8 Methadone dose in opioid dependence; CESC cis rs9399135 0.967 rs45544135 chr6:135324051 T/C cg22676075 chr6:135203613 NA 0.52 7.32 0.41 2.99e-12 Red blood cell count; CESC cis rs10838687 0.825 rs12222581 chr11:47342019 A/T cg25783544 chr11:47291846 MADD 0.59 7.26 0.41 4.24e-12 Proinsulin levels; CESC cis rs9325144 0.560 rs10785573 chr12:38654166 G/A cg26384229 chr12:38710491 ALG10B -0.6 -8.49 -0.46 1.45e-15 Morning vs. evening chronotype; CESC cis rs1801251 1.000 rs283471 chr2:233656627 G/A cg25237894 chr2:233734115 C2orf82 0.46 7.88 0.44 8.69e-14 Coronary artery disease; CESC trans rs9467711 0.606 rs68072215 chr6:26377927 T/C cg06606381 chr12:133084897 FBRSL1 -0.73 -6.26 -0.36 1.53e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9309473 0.583 rs11899517 chr2:73573261 A/G cg20560298 chr2:73613845 ALMS1 -0.48 -6.51 -0.37 3.79e-10 Metabolite levels; CESC cis rs35110281 0.743 rs230640 chr21:44914815 A/T cg21573476 chr21:45109991 RRP1B 0.44 6.22 0.36 1.95e-9 Mean corpuscular volume; CESC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.02 10.52 0.54 7.59e-22 Gut microbiome composition (summer); CESC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg26354017 chr1:205819088 PM20D1 0.85 13.02 0.62 2.82e-30 Menarche (age at onset); CESC cis rs362272 0.545 rs3135146 chr4:3307638 C/G cg14583973 chr4:3374767 RGS12 -0.31 -5.31 -0.31 2.27e-7 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19306474 chr10:6243561 PFKFB3 0.54 6.04 0.35 5.06e-9 Gut microbiome composition (summer); CESC cis rs738322 0.967 rs132971 chr22:38561911 T/G cg25457927 chr22:38595422 NA -0.3 -5.6 -0.33 5.25e-8 Cutaneous nevi; CESC cis rs10870270 0.956 rs11146325 chr10:133767529 A/G cg17892150 chr10:133769511 PPP2R2D -0.87 -12.67 -0.61 4.28e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs718433 0.584 rs7142784 chr14:22213799 C/T cg02257791 chr14:22217085 NA -0.33 -5.14 -0.3 5.32e-7 Intraocular pressure; CESC cis rs9875589 0.509 rs4684174 chr3:14048375 C/T cg19554555 chr3:13937349 NA -0.44 -5.65 -0.33 4.16e-8 Ovarian reserve; CESC cis rs10979 1.000 rs9390113 chr6:143896205 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06168319 chr4:84205972 COQ2 0.63 7.43 0.42 1.49e-12 Gut microbiome composition (summer); CESC cis rs709400 0.859 rs7693 chr14:104023704 C/T cg12935359 chr14:103987150 CKB -0.51 -6.71 -0.38 1.2e-10 Body mass index; CESC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg26441486 chr22:50317300 CRELD2 0.4 5.55 0.32 6.82e-8 Schizophrenia; CESC cis rs854765 0.583 rs11078406 chr17:17840823 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.63 9.35 0.5 3.76e-18 Total body bone mineral density; CESC cis rs8040855 0.627 rs11637512 chr15:85648759 T/C cg08123816 chr15:85640762 PDE8A -0.39 -5.74 -0.33 2.6e-8 Bulimia nervosa; CESC cis rs941873 0.803 rs2105461 chr10:81101679 A/G cg08514558 chr10:81106712 PPIF -0.35 -6.08 -0.35 4.21e-9 Height; CESC cis rs9790314 1.000 rs336579 chr3:161086610 G/A cg04691961 chr3:161091175 C3orf57 -0.44 -5.64 -0.33 4.39e-8 Morning vs. evening chronotype; CESC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg15572086 chr1:116961459 C1orf203 0.55 6.23 0.36 1.84e-9 Psoriatic arthritis; CESC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg00684032 chr4:1343700 KIAA1530 0.4 5.51 0.32 8.35e-8 Obesity-related traits; CESC cis rs7123876 0.830 rs59311588 chr11:72435996 A/G cg03713592 chr11:72463424 ARAP1 0.6 6.77 0.38 8.21e-11 Body mass index; CESC cis rs10870270 0.957 rs9971084 chr10:133788747 G/C cg17892150 chr10:133769511 PPP2R2D -0.85 -12.42 -0.61 3.3e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg22433210 chr17:43662623 NA -0.93 -10.69 -0.55 2.14e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08925066 chr14:39572669 SEC23A 0.64 7.35 0.41 2.42e-12 Gut microbiome composition (summer); CESC cis rs4969178 0.932 rs3744219 chr17:76400236 G/A cg05887092 chr17:76393375 PGS1 0.58 9.26 0.49 7e-18 HDL cholesterol levels; CESC cis rs9818758 0.607 rs56306491 chr3:49314960 G/A cg00383909 chr3:49044727 WDR6 0.89 5.94 0.34 8.93e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs262150 1.000 rs262154 chr7:158773936 G/A cg19418458 chr7:158789849 NA -0.49 -7.69 -0.43 2.97e-13 Facial morphology (factor 20); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05993306 chr5:137090649 HNRNPA0 -0.52 -7.11 -0.4 1.11e-11 Gut microbiota (bacterial taxa); CESC cis rs9611519 0.780 rs9611528 chr22:41648502 T/C cg03806693 chr22:41940476 POLR3H -0.57 -6.52 -0.37 3.59e-10 Neuroticism; CESC cis rs1008375 0.902 rs7654332 chr4:17691778 A/T cg02297831 chr4:17616191 MED28 0.5 5.95 0.34 8.38e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12410462 0.579 rs77529417 chr1:227547895 T/C cg04117972 chr1:227635322 NA 0.63 5.35 0.31 1.9e-7 Major depressive disorder; CESC cis rs6032067 0.673 rs13042474 chr20:43893068 G/T cg10761708 chr20:43804764 PI3 0.41 5.14 0.3 5.43e-7 Blood protein levels; CESC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg23462726 chr11:62437636 C11orf83;C11orf48 -0.44 -5.84 -0.34 1.56e-8 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs7580658 0.676 rs4150407 chr2:128049631 C/T cg10021288 chr2:128175891 PROC 0.34 5.6 0.33 5.33e-8 Protein C levels; CESC cis rs11122272 0.766 rs2739511 chr1:231526490 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.22 -0.45 9.37e-15 Hemoglobin concentration; CESC cis rs2204008 0.805 rs3863360 chr12:37966432 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.51 0.5 1.2e-18 Bladder cancer; CESC cis rs5769765 0.955 rs5769761 chr22:50263641 G/T cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs17666538 0.585 rs4333567 chr8:636611 C/T cg23958373 chr8:599963 NA 0.81 5.1 0.3 6.6e-7 IgG glycosylation; CESC cis rs9611565 0.592 rs5758427 chr22:42099688 A/G cg06481639 chr22:41940642 POLR3H 0.64 6.55 0.37 2.94e-10 Vitiligo; CESC cis rs4595586 0.525 rs73096109 chr12:39355720 C/A cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.09e-8 Morning vs. evening chronotype; CESC trans rs4904167 0.841 rs12436650 chr14:84679067 A/G cg06870609 chr15:89787223 FANCI 0.46 6.01 0.35 6.03e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg04414720 chr1:150670196 GOLPH3L 0.51 6.78 0.38 7.88e-11 Melanoma; CESC cis rs2276314 1.000 rs9304153 chr18:33562150 T/C cg19628046 chr18:33552617 C18orf21 0.53 5.72 0.33 2.83e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs3752962 0.588 rs903164 chr17:1939502 G/A cg24156229 chr17:1948635 NA -0.65 -9.81 -0.52 1.38e-19 Itch intensity from mosquito bite; CESC cis rs2070433 0.706 rs2268524 chr21:47838700 C/T cg12379764 chr21:47803548 PCNT 0.67 7.31 0.41 3.08e-12 Lymphocyte counts; CESC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.71 8.51 0.46 1.3e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9815354 0.680 rs73073294 chr3:42028053 A/G cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs2228479 0.702 rs17177891 chr16:89799950 C/T cg04013166 chr16:89971882 TCF25 0.74 6.37 0.36 8.27e-10 Skin colour saturation; CESC trans rs2727020 0.718 rs1404366 chr11:49415899 T/A cg15704280 chr7:45808275 SEPT13 -0.8 -10.1 -0.53 1.66e-20 Coronary artery disease; CESC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg13770153 chr20:60521292 NA -0.5 -6.48 -0.37 4.33e-10 Body mass index; CESC cis rs8058578 1.000 rs56656810 chr16:30788759 C/A cg02466173 chr16:30829666 NA -0.45 -7.23 -0.41 5.16e-12 Multiple myeloma; CESC trans rs1728785 0.901 rs1170420 chr16:68635877 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 7.69 0.43 2.91e-13 Ulcerative colitis; CESC cis rs3733585 0.699 rs6449176 chr4:9967843 G/A cg00071950 chr4:10020882 SLC2A9 -0.7 -11.44 -0.58 6.69e-25 Cleft plate (environmental tobacco smoke interaction); CESC cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg09658497 chr7:2847517 GNA12 -0.36 -5.41 -0.32 1.39e-7 Height; CESC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.72 0.33 2.89e-8 Bipolar disorder; CESC cis rs919433 0.783 rs788007 chr2:198233676 T/G cg03934865 chr2:198174659 NA 0.43 6.21 0.36 2.01e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2599510 0.811 rs2710615 chr2:32791222 A/T cg02381751 chr2:32503542 YIPF4 0.52 6.54 0.37 3.24e-10 Interleukin-18 levels; CESC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg12463550 chr7:65579703 CRCP 0.59 7.52 0.42 8.29e-13 Aortic root size; CESC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg22105103 chr4:187893119 NA 0.47 7.01 0.4 1.94e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs713587 0.525 rs1541984 chr2:25082414 G/A cg01884057 chr2:25150051 NA 0.35 6.58 0.37 2.53e-10 Body mass index in non-asthmatics; CESC cis rs4746818 0.793 rs2805913 chr10:70858062 A/G cg11621586 chr10:70884670 VPS26A 0.71 8.09 0.45 2.13e-14 Left atrial antero-posterior diameter; CESC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg22823121 chr1:150693482 HORMAD1 0.37 5.26 0.31 3.01e-7 Melanoma; CESC cis rs6032067 0.929 rs2233883 chr20:43835822 T/C cg10761708 chr20:43804764 PI3 0.5 5.94 0.34 8.83e-9 Blood protein levels; CESC cis rs1062177 0.855 rs919263 chr5:151265853 A/G cg00977110 chr5:151150581 G3BP1 0.52 5.82 0.34 1.66e-8 Preschool internalizing problems; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20095338 chr12:76478402 NAP1L1 0.46 6.25 0.36 1.59e-9 Gut microbiota (bacterial taxa); CESC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg00166722 chr3:10149974 C3orf24 0.45 5.63 0.33 4.62e-8 Alzheimer's disease; CESC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs13242816 1.000 rs35364754 chr7:116109716 T/G cg04696780 chr7:116139425 CAV2 -0.63 -5.71 -0.33 2.98e-8 P wave duration; CESC cis rs933688 1.000 rs332531 chr5:90790451 G/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.89 10.36 0.54 2.38e-21 Smoking behavior; CESC cis rs858239 0.600 rs10237755 chr7:23131564 A/G cg23682824 chr7:23144976 KLHL7 0.55 7.67 0.43 3.39e-13 Cerebrospinal fluid biomarker levels; CESC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg18876405 chr7:65276391 NA 0.52 7.09 0.4 1.24e-11 Aortic root size; CESC cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg02297831 chr4:17616191 MED28 0.44 5.4 0.32 1.45e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11098499 0.954 rs9998585 chr4:120396802 T/A cg25214090 chr10:38739885 LOC399744 0.72 10.31 0.54 3.55e-21 Corneal astigmatism; CESC cis rs9399135 0.904 rs4895438 chr6:135317665 G/T cg22676075 chr6:135203613 NA 0.51 7.19 0.4 6.51e-12 Red blood cell count; CESC cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg18904891 chr8:8559673 CLDN23 0.71 8.07 0.44 2.44e-14 Obesity-related traits; CESC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg00784671 chr22:46762841 CELSR1 -0.51 -5.8 -0.34 1.92e-8 LDL cholesterol;Cholesterol, total; CESC cis rs11871801 0.517 rs60929812 chr17:40759448 G/A cg14558262 chr17:40713999 COASY 0.5 5.83 0.34 1.58e-8 Crohn's disease; CESC cis rs826838 0.620 rs11614695 chr12:39331847 C/T cg26384229 chr12:38710491 ALG10B 0.74 11.1 0.56 9.41e-24 Heart rate; CESC cis rs4594175 0.926 rs60234748 chr14:51630102 T/C cg23942311 chr14:51606299 NA 0.4 6.21 0.36 2.01e-9 Cancer; CESC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg00166722 chr3:10149974 C3orf24 0.45 5.67 0.33 3.82e-8 Alzheimer's disease; CESC trans rs2018683 0.683 rs12538606 chr7:28969408 T/C cg19402173 chr7:128379420 CALU -0.5 -6.78 -0.38 7.59e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs6582630 0.555 rs2387598 chr12:38510472 G/A cg13010199 chr12:38710504 ALG10B -0.43 -5.44 -0.32 1.19e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg02297831 chr4:17616191 MED28 0.57 7.0 0.4 2.05e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9916302 0.706 rs7208252 chr17:37584368 A/G cg07936489 chr17:37558343 FBXL20 -0.91 -9.93 -0.52 5.62e-20 Glomerular filtration rate (creatinine); CESC cis rs6088580 0.634 rs6059779 chr20:32950325 C/T cg08999081 chr20:33150536 PIGU -0.65 -11.53 -0.58 3.34e-25 Glomerular filtration rate (creatinine); CESC cis rs941873 0.835 rs10762859 chr10:81103370 T/A cg11057378 chr10:81107060 PPIF 0.32 5.17 0.3 4.72e-7 Height; CESC cis rs9359856 0.564 rs34732313 chr6:90368380 G/A cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.35 -0.36 9.29e-10 Bipolar disorder; CESC cis rs910316 0.967 rs12890371 chr14:75593839 T/C cg11812906 chr14:75593930 NEK9 0.9 15.44 0.69 8.28e-39 Height; CESC cis rs5758659 0.716 rs86669 chr22:42680800 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.31 -5.55 -0.32 6.98e-8 Cognitive function; CESC cis rs1144333 1.000 rs1144333 chr1:76275100 A/G cg03433033 chr1:76189801 ACADM -0.52 -5.06 -0.3 8.01e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs67460515 0.892 rs11711413 chr3:160998910 C/G cg03342759 chr3:160939853 NMD3 -0.53 -7.59 -0.42 5.43e-13 Parkinson's disease; CESC cis rs10883723 0.810 rs6584508 chr10:104258567 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.42 0.41 1.55e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs6540556 0.724 rs6679631 chr1:209935491 C/A cg05527609 chr1:210001259 C1orf107 -0.44 -5.55 -0.32 6.87e-8 Red blood cell count; CESC cis rs1178968 1.000 rs12534600 chr7:72762721 C/T cg25889504 chr7:72793014 NA -0.49 -5.18 -0.3 4.38e-7 Triglyceride levels; CESC cis rs13385 0.769 rs4913078 chr5:139626680 A/T cg26211634 chr5:139558579 C5orf32 0.47 5.18 0.3 4.33e-7 Atrial fibrillation; CESC cis rs9532580 0.778 rs34373380 chr13:41244217 T/A cg21288729 chr13:41239152 FOXO1 0.68 8.46 0.46 1.82e-15 Mean corpuscular hemoglobin; CESC cis rs7116495 0.609 rs4245463 chr11:71743213 C/A cg18441811 chr11:71824068 C11orf51 -0.87 -5.33 -0.31 2.07e-7 Severe influenza A (H1N1) infection; CESC cis rs2228479 0.850 rs12597299 chr16:89822364 C/A cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs35110281 0.805 rs8131005 chr21:45041954 T/C cg21573476 chr21:45109991 RRP1B -0.4 -5.77 -0.33 2.2e-8 Mean corpuscular volume; CESC cis rs4906332 0.966 rs17679729 chr14:103924312 A/G cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.34e-10 Coronary artery disease; CESC cis rs820218 0.926 rs1661744 chr17:73647138 C/T cg01592526 chr17:73663357 RECQL5;SAP30BP 0.41 5.47 0.32 1.03e-7 Rotator cuff tears; CESC cis rs55871839 0.708 rs10112089 chr8:59813429 C/T cg07426533 chr8:59803705 TOX -0.47 -7.01 -0.4 1.95e-11 Pneumonia; CESC cis rs2439831 0.764 rs12324584 chr15:43683446 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.86 12.81 0.62 1.51e-29 Lung cancer in ever smokers; CESC cis rs4835473 0.900 rs4835303 chr4:144742686 T/C cg25736465 chr4:144833511 NA -0.32 -5.07 -0.3 7.42e-7 Immature fraction of reticulocytes; CESC cis rs778371 0.723 rs6710294 chr2:233579634 T/C cg08000102 chr2:233561755 GIGYF2 0.84 14.38 0.66 4.81e-35 Schizophrenia; CESC cis rs10504073 0.584 rs4873307 chr8:49950417 C/T cg00325661 chr8:49890786 NA 0.55 8.21 0.45 9.72e-15 Blood metabolite ratios; CESC cis rs2742234 0.590 rs2435337 chr10:43661836 G/C cg07801480 chr10:43725741 RASGEF1A 0.46 5.76 0.33 2.3e-8 Hirschsprung disease; CESC cis rs8014204 1.000 rs4553560 chr14:75334199 T/C cg08847533 chr14:75593920 NEK9 -0.47 -5.88 -0.34 1.25e-8 Caffeine consumption; CESC cis rs4834770 0.717 rs1022146 chr4:120236103 A/G cg09307838 chr4:120376055 NA 0.51 6.46 0.37 4.87e-10 Blood protein levels; CESC cis rs9611565 0.694 rs5758389 chr22:41941749 T/C cg17376030 chr22:41985996 PMM1 0.46 5.36 0.31 1.79e-7 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01936430 chr1:204380496 PPP1R15B 0.62 7.37 0.41 2.11e-12 Gut microbiome composition (summer); CESC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg07507251 chr3:52567010 NT5DC2 0.32 5.61 0.33 5.12e-8 Bipolar disorder; CESC cis rs6987853 0.787 rs2974354 chr8:42413943 A/G cg09913449 chr8:42400586 C8orf40 0.44 7.24 0.41 4.99e-12 Mean corpuscular hemoglobin concentration; CESC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg23708337 chr7:1209742 NA 0.54 5.4 0.31 1.48e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg22903657 chr4:1355424 KIAA1530 -0.37 -5.13 -0.3 5.63e-7 Obesity-related traits; CESC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg11644478 chr21:40555479 PSMG1 -0.83 -12.92 -0.62 5.85e-30 Cognitive function; CESC cis rs6429082 0.818 rs291383 chr1:235643100 G/A cg26050004 chr1:235667680 B3GALNT2 0.62 7.83 0.43 1.19e-13 Adiposity; CESC cis rs950776 0.616 rs6495307 chr15:78890321 C/T cg24631222 chr15:78858424 CHRNA5 -0.43 -5.43 -0.32 1.25e-7 Sudden cardiac arrest; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18947032 chr10:70748274 KIAA1279 -0.51 -6.26 -0.36 1.53e-9 Gut microbiome composition (summer); CESC cis rs7944584 0.511 rs10838725 chr11:47557871 T/C cg20307385 chr11:47447363 PSMC3 0.83 12.3 0.6 8.59e-28 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs2625529 0.526 rs8040828 chr15:72492779 C/A cg16672083 chr15:72433130 SENP8 0.47 7.05 0.4 1.57e-11 Red blood cell count; CESC cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg17211192 chr8:82754475 SNX16 0.5 6.41 0.37 6.74e-10 Diastolic blood pressure; CESC cis rs4481887 0.927 rs10888343 chr1:248446642 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.79 0.39 7.3e-11 Common traits (Other); CESC trans rs607987 0.836 rs1222203 chr11:30336334 A/G cg25993608 chr18:76621396 NA -0.42 -6.0 -0.35 6.63e-9 Body mass index; CESC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg06713675 chr4:122721982 EXOSC9 -0.51 -7.01 -0.4 1.94e-11 Type 2 diabetes; CESC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg05368731 chr17:41323189 NBR1 0.77 10.41 0.54 1.7e-21 Menopause (age at onset); CESC cis rs7481584 0.847 rs1468102 chr11:3004526 C/G cg25174290 chr11:3078921 CARS -0.48 -5.88 -0.34 1.22e-8 Calcium levels; CESC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg03264133 chr6:25882463 NA 0.37 6.13 0.35 3.21e-9 Blood metabolite levels; CESC cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg04455712 chr21:45112962 RRP1B 0.49 7.87 0.44 8.94e-14 Mean corpuscular volume; CESC cis rs9522267 0.535 rs9522301 chr13:112236726 A/T cg10483660 chr13:112241077 NA -0.32 -5.74 -0.33 2.64e-8 Hepatitis; CESC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.54 0.32 7.25e-8 Personality dimensions; CESC cis rs1348850 0.651 rs4893821 chr2:178229352 A/G cg22681709 chr2:178499509 PDE11A 0.37 5.57 0.32 6.29e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7429990 0.965 rs9846062 chr3:47998966 A/G cg11946769 chr3:48343235 NME6 0.45 5.34 0.31 2.01e-7 Educational attainment (years of education); CESC cis rs6088580 0.634 rs6120669 chr20:33105028 T/C cg08999081 chr20:33150536 PIGU 0.65 11.47 0.58 5.24e-25 Glomerular filtration rate (creatinine); CESC cis rs6815814 0.799 rs11466640 chr4:38778903 A/G cg02016764 chr4:38805732 TLR1 0.68 7.9 0.44 7.55e-14 Breast cancer; CESC cis rs62103177 0.564 rs2115996 chr18:77701007 C/G cg12964065 chr18:77638022 KCNG2 0.53 5.98 0.34 7.25e-9 Opioid sensitivity; CESC trans rs4716602 0.596 rs10261230 chr7:156159632 C/T cg07175507 chr18:77160758 NFATC1 -0.44 -6.04 -0.35 5.07e-9 Anti-saccade response; CESC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg24585782 chr17:78113791 EIF4A3 -0.57 -7.48 -0.42 1.08e-12 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg06212747 chr3:49208901 KLHDC8B 0.69 9.08 0.49 2.64e-17 Parkinson's disease; CESC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg27170947 chr2:26402098 FAM59B -0.59 -6.9 -0.39 3.83e-11 Gut microbiome composition (summer); CESC trans rs2727020 0.521 rs10839299 chr11:49573981 C/T cg15704280 chr7:45808275 SEPT13 -0.84 -10.3 -0.53 3.95e-21 Coronary artery disease; CESC cis rs9902453 0.934 rs4427857 chr17:28457989 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.29 0.45 5.57e-15 Coffee consumption (cups per day); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05719672 chr15:91446576 MAN2A2 0.46 6.46 0.37 5.11e-10 Gut microbiota (bacterial taxa); CESC cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg18904891 chr8:8559673 CLDN23 -0.68 -8.21 -0.45 9.79e-15 Obesity-related traits; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03574882 chr7:151574332 PRKAG2 -0.45 -6.45 -0.37 5.14e-10 Fibrinogen levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00552226 chr2:70475288 TIA1 -0.45 -6.02 -0.35 5.82e-9 Height; CESC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg02569458 chr12:86230093 RASSF9 0.56 8.07 0.44 2.43e-14 Major depressive disorder; CESC cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg11752832 chr7:134001865 SLC35B4 0.53 6.89 0.39 3.99e-11 Mean platelet volume; CESC cis rs1008375 0.898 rs7678654 chr4:17575376 T/G cg16339924 chr4:17578868 LAP3 0.74 9.56 0.51 8.75e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12129596 chr19:55770037 SAPS1 0.5 6.04 0.35 5.1e-9 Gut microbiome composition (summer); CESC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs6088590 0.687 rs73106933 chr20:33287425 T/C cg06115741 chr20:33292138 TP53INP2 0.52 6.45 0.37 5.37e-10 Coronary artery disease; CESC cis rs2603127 0.768 rs9873564 chr3:108496627 G/T cg03329597 chr3:108125523 MYH15 0.57 5.35 0.31 1.95e-7 Hemostatic factors and hematological phenotypes; CESC cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg10523679 chr1:76189770 ACADM -0.65 -6.61 -0.38 2.12e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg00255919 chr5:131827918 IRF1 -0.36 -5.16 -0.3 4.8e-7 Breast cancer;Mosquito bite size; CESC cis rs4268898 0.662 rs72793213 chr2:24524725 A/G cg08917208 chr2:24149416 ATAD2B 0.52 5.2 0.3 4.02e-7 Asthma; CESC cis rs9325144 0.560 rs10785586 chr12:38676197 G/A cg26384229 chr12:38710491 ALG10B -0.6 -8.45 -0.46 1.97e-15 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.692 rs8037005 chr15:76951109 C/T cg26408565 chr15:76604113 ETFA -0.4 -5.69 -0.33 3.3e-8 Blood metabolite levels; CESC cis rs911555 0.539 rs4374097 chr14:104072766 A/C cg24130564 chr14:104152367 KLC1 -0.79 -13.02 -0.62 2.7e-30 Intelligence (multi-trait analysis); CESC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg26939375 chr7:64535504 NA -0.74 -10.62 -0.55 3.37e-22 Aortic root size; CESC cis rs939574 0.790 rs2385397 chr2:220087796 G/T cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.88 -7.91 -0.44 6.98e-14 Platelet distribution width; CESC cis rs10791097 0.967 rs1944142 chr11:130717440 C/T cg12179176 chr11:130786555 SNX19 0.54 7.78 0.43 1.6e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9902453 0.967 rs7222685 chr17:28496430 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.84 0.43 1.08e-13 Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09508119 chr19:506588 C19orf20 0.59 6.61 0.38 2.16e-10 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.59 -0.38 2.36e-10 Depression; CESC cis rs11764590 0.651 rs12673687 chr7:2081873 C/T cg21782813 chr7:2030301 MAD1L1 -0.4 -5.23 -0.31 3.45e-7 Neuroticism; CESC cis rs8020095 0.571 rs7142669 chr14:67250392 A/C cg19548862 chr14:67692701 FAM71D -0.5 -6.2 -0.36 2.13e-9 Depression (quantitative trait); CESC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg24562669 chr7:97807699 LMTK2 0.5 7.26 0.41 4.26e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs1348850 0.837 rs4243388 chr2:178284604 T/G cg22681709 chr2:178499509 PDE11A -0.42 -6.23 -0.36 1.79e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9863 0.861 rs11833002 chr12:124446616 G/A cg00084347 chr12:124393913 DNAH10 0.27 5.28 0.31 2.71e-7 White blood cell count; CESC cis rs9341808 0.628 rs1892475 chr6:80862213 T/C cg08355045 chr6:80787529 NA 0.32 5.03 0.3 8.88e-7 Sitting height ratio; CESC cis rs3126085 0.935 rs3126046 chr1:152256925 G/A cg03465714 chr1:152285911 FLG 0.46 5.74 0.33 2.61e-8 Atopic dermatitis; CESC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg22963979 chr7:1858916 MAD1L1 -0.37 -5.11 -0.3 6.25e-7 Bipolar disorder and schizophrenia; CESC trans rs1814175 0.817 rs80244685 chr11:49763292 C/A cg15704280 chr7:45808275 SEPT13 -1.0 -17.46 -0.73 5.98e-46 Height; CESC cis rs1707322 1.000 rs4660334 chr1:46462126 A/C cg05343316 chr1:45956843 TESK2 0.45 5.46 0.32 1.09e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10927875 0.864 rs12135073 chr1:16167799 C/T cg21385522 chr1:16154831 NA 0.89 12.39 0.61 3.95e-28 Dilated cardiomyopathy; CESC cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg14500267 chr11:67383377 NA 0.36 5.72 0.33 2.93e-8 Mean corpuscular volume; CESC cis rs7264396 0.779 rs2425162 chr20:34429974 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.6 7.04 0.4 1.67e-11 Total cholesterol levels; CESC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.65e-39 Menopause (age at onset); CESC cis rs9308731 0.644 rs3789068 chr2:111909247 A/G cg04202892 chr2:111875749 ACOXL 0.43 6.13 0.35 3.18e-9 Chronic lymphocytic leukemia; CESC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg07157834 chr1:205819609 PM20D1 0.39 5.2 0.3 4.06e-7 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.11e-8 Alzheimer's disease; CESC cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg14416269 chr4:6271139 WFS1 -0.44 -7.37 -0.41 2.23e-12 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg06627628 chr2:24431161 ITSN2 -0.68 -6.51 -0.37 3.81e-10 Lymphocyte counts; CESC cis rs11190604 1.000 rs7099965 chr10:102301165 A/G cg07080220 chr10:102295463 HIF1AN 0.66 6.04 0.35 5.08e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs5769765 0.955 rs61136468 chr22:50312679 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.48 -5.43 -0.32 1.25e-7 Schizophrenia; CESC cis rs7336332 0.569 rs57724994 chr13:28010389 T/C cg22138327 chr13:27999177 GTF3A 0.49 5.12 0.3 5.78e-7 Weight; CESC cis rs72945132 0.882 rs3133179 chr11:70187574 T/G cg14191688 chr11:70257035 CTTN 0.43 5.51 0.32 8.64e-8 Coronary artery disease; CESC cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg25019033 chr10:957182 NA -0.59 -6.29 -0.36 1.32e-9 Eosinophil percentage of granulocytes; CESC cis rs2204008 0.905 rs7294297 chr12:38442573 T/C cg13010199 chr12:38710504 ALG10B 0.42 5.43 0.32 1.28e-7 Bladder cancer; CESC cis rs2282802 0.685 rs7730245 chr5:139628163 C/A cg26211634 chr5:139558579 C5orf32 0.51 7.29 0.41 3.55e-12 Intelligence (multi-trait analysis); CESC cis rs7107174 0.792 rs2888465 chr11:77945807 T/C cg02023728 chr11:77925099 USP35 0.55 7.2 0.4 6.14e-12 Testicular germ cell tumor; CESC cis rs7077164 1.000 rs1227764 chr10:71583223 G/A cg20696214 chr10:71583771 COL13A1 -0.46 -6.31 -0.36 1.2e-9 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.37 -5.95 -0.34 8.5e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg20307385 chr11:47447363 PSMC3 -0.58 -6.95 -0.39 2.81e-11 Subjective well-being; CESC cis rs62408225 1.000 rs62408222 chr6:90948476 A/G cg06866423 chr6:90926672 BACH2 0.51 6.21 0.36 2e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25441200 chr7:156742235 NOM1 0.44 6.08 0.35 4.17e-9 Systemic lupus erythematosus; CESC cis rs1707322 1.000 rs785478 chr1:46491635 C/T cg06784218 chr1:46089804 CCDC17 -0.34 -5.96 -0.34 7.95e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg05535760 chr7:792225 HEATR2 -0.74 -7.7 -0.43 2.64e-13 Cerebrospinal P-tau181p levels; CESC cis rs8114671 0.647 rs945959 chr20:33734905 G/C cg24642439 chr20:33292090 TP53INP2 0.51 6.5 0.37 3.86e-10 Height; CESC cis rs72781680 0.644 rs72783627 chr2:24315685 A/C cg06627628 chr2:24431161 ITSN2 -0.68 -6.58 -0.37 2.44e-10 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03362689 chr3:49044465 P4HTM;WDR6 -0.54 -6.25 -0.36 1.62e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09148975 chr1:38274245 C1orf122;YRDC 0.57 6.18 0.35 2.42e-9 Gut microbiome composition (summer); CESC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg03806693 chr22:41940476 POLR3H 1.18 13.88 0.65 2.76e-33 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27402845 chr11:1000533 AP2A2 -0.55 -6.2 -0.36 2.21e-9 Gut microbiome composition (summer); CESC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg24060327 chr5:131705240 SLC22A5 -0.74 -9.94 -0.52 5.55e-20 Acylcarnitine levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg21242684 chr2:98262069 COX5B -0.44 -6.2 -0.36 2.19e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs611744 0.647 rs1584373 chr8:109263399 C/A cg21045802 chr8:109455806 TTC35 0.46 5.7 0.33 3.13e-8 Dupuytren's disease; CESC cis rs3096299 0.679 rs3102338 chr16:89442250 C/G cg08392591 chr16:89556376 ANKRD11 0.41 5.22 0.31 3.55e-7 Multiple myeloma (IgH translocation); CESC cis rs11098499 0.954 rs35063680 chr4:120387102 T/C cg24375607 chr4:120327624 NA 0.44 5.48 0.32 9.91e-8 Corneal astigmatism; CESC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg18016565 chr1:150552671 MCL1 -0.37 -5.4 -0.31 1.51e-7 Blood protein levels; CESC cis rs34779708 0.966 rs878264 chr10:35440581 T/C cg04310649 chr10:35416472 CREM -0.54 -6.69 -0.38 1.35e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs10992471 0.756 rs7027595 chr9:95131553 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -5.68 -0.33 3.52e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs2730245 0.636 rs2657382 chr7:158650941 G/A cg24397884 chr7:158709396 WDR60 0.72 10.29 0.53 4.05e-21 Height; CESC cis rs763121 0.962 rs909564 chr22:39126508 A/G cg21395723 chr22:39101663 GTPBP1 0.39 5.22 0.31 3.6e-7 Menopause (age at onset); CESC cis rs6460942 1.000 rs7808819 chr7:12297440 C/T cg02935154 chr7:12443704 VWDE -0.59 -5.82 -0.34 1.69e-8 Coronary artery disease; CESC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg12963246 chr6:28129442 ZNF389 0.48 6.3 0.36 1.2e-9 Parkinson's disease; CESC cis rs8067545 0.750 rs9915758 chr17:19964775 A/G cg13482628 chr17:19912719 NA 0.38 5.07 0.3 7.57e-7 Schizophrenia; CESC cis rs1865721 0.804 rs72977818 chr18:73146852 T/C cg26385618 chr18:73139727 C18orf62 -0.52 -8.21 -0.45 1e-14 Intelligence; CESC cis rs938554 0.612 rs28592748 chr4:9998605 T/C cg11266682 chr4:10021025 SLC2A9 0.47 6.54 0.37 3.22e-10 Blood metabolite levels; CESC cis rs3015497 0.967 rs3015483 chr14:51137474 C/G cg26011998 chr14:51135199 SAV1 -0.41 -5.18 -0.3 4.4e-7 Mean platelet volume; CESC cis rs4683142 0.518 rs6802312 chr3:46025941 T/C cg18004856 chr3:46029278 FYCO1 0.4 5.52 0.32 8.01e-8 Methadone dose in opioid dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22120017 chr8:101964390 YWHAZ 0.6 6.53 0.37 3.41e-10 Gut microbiome composition (summer); CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg14159672 chr1:205819179 PM20D1 0.93 16.31 0.71 6.74e-42 Menarche (age at onset); CESC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg09263875 chr16:632152 PIGQ 0.67 11.29 0.57 2.08e-24 Height; CESC cis rs67478160 0.619 rs55824307 chr14:104271207 C/T cg08213375 chr14:104286397 PPP1R13B 0.54 10.79 0.55 9.69e-23 Schizophrenia; CESC cis rs6963495 0.818 rs117887993 chr7:105193837 T/G cg02135003 chr7:105160482 PUS7 -0.48 -5.66 -0.33 3.95e-8 Bipolar disorder (body mass index interaction); CESC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg22823121 chr1:150693482 HORMAD1 0.46 6.75 0.38 9.54e-11 Tonsillectomy; CESC cis rs5769765 1.000 rs5770742 chr22:50270309 T/C cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.7 -7.96 -0.44 5.16e-14 Alzheimer's disease; CESC cis rs8067545 0.750 rs4925081 chr17:19991993 A/G cg13482628 chr17:19912719 NA -0.37 -5.13 -0.3 5.6e-7 Schizophrenia; CESC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.09 20.61 0.78 5.5e-57 Prudent dietary pattern; CESC cis rs17376456 0.825 rs17372615 chr5:93124768 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.26 0.31 3.01e-7 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25149927 chr12:109250901 SSH1 -0.59 -6.94 -0.39 3e-11 Gut microbiome composition (summer); CESC cis rs709400 0.930 rs61996717 chr14:104048571 T/C cg12935359 chr14:103987150 CKB -0.5 -6.31 -0.36 1.16e-9 Body mass index; CESC trans rs877282 0.945 rs11253397 chr10:789774 A/G cg22713356 chr15:30763199 NA 1.32 13.44 0.64 9.25e-32 Uric acid levels; CESC cis rs10242455 0.571 rs28365067 chr7:99272310 G/A cg25640893 chr7:99214727 ZNF498 0.96 6.17 0.35 2.53e-9 Blood metabolite levels; CESC cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg03676636 chr4:99064102 C4orf37 0.33 5.13 0.3 5.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2777491 0.915 rs7178777 chr15:41634588 C/A cg20272979 chr15:41787780 ITPKA 0.36 5.33 0.31 2.09e-7 Ulcerative colitis; CESC cis rs6963495 0.818 rs6955796 chr7:105170321 T/G cg13798780 chr7:105162888 PUS7 0.77 7.88 0.44 8.3e-14 Bipolar disorder (body mass index interaction); CESC cis rs17125944 0.686 rs11621275 chr14:53363316 C/G cg00686598 chr14:53173677 PSMC6 -0.57 -5.16 -0.3 4.78e-7 Alzheimer's disease (late onset); CESC cis rs11792861 0.926 rs76689835 chr9:111833792 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 5.31 0.31 2.29e-7 Menarche (age at onset); CESC trans rs6467710 1.000 rs6467710 chr7:137203819 C/G cg14964336 chr4:1523275 NA 0.96 6.05 0.35 4.91e-9 AIDS progression; CESC cis rs9911578 0.933 rs11868348 chr17:57179238 C/T cg12560992 chr17:57184187 TRIM37 1.01 17.89 0.74 1.77e-47 Intelligence (multi-trait analysis); CESC cis rs2204008 0.550 rs11495600 chr12:38126654 C/T cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg25427524 chr10:38739819 LOC399744 -0.78 -12.07 -0.6 4.98e-27 Breast cancer; CESC cis rs4654899 1.000 rs6703227 chr1:21374810 A/G cg05370193 chr1:21551575 ECE1 0.4 6.13 0.35 3.18e-9 Superior frontal gyrus grey matter volume; CESC cis rs6775745 0.541 rs16838395 chr3:131755693 A/G cg12213930 chr3:131751605 CPNE4 -0.48 -5.38 -0.31 1.66e-7 Neutrophil count; CESC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg17143192 chr8:8559678 CLDN23 0.74 8.83 0.48 1.5e-16 Obesity-related traits; CESC cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg19077165 chr18:44547161 KATNAL2 0.48 6.54 0.37 3.09e-10 Personality dimensions; CESC cis rs67478160 0.643 rs11626377 chr14:104234357 G/A cg01849466 chr14:104193079 ZFYVE21 -0.5 -6.89 -0.39 4.13e-11 Schizophrenia; CESC cis rs9303401 0.659 rs34275691 chr17:56736640 A/T cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.13 0.63 1.12e-30 Cognitive test performance; CESC cis rs7116495 0.609 rs4944243 chr11:71674354 T/C cg10381502 chr11:71823885 C11orf51 -1.18 -7.71 -0.43 2.53e-13 Severe influenza A (H1N1) infection; CESC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg04369109 chr6:150039330 LATS1 -0.43 -5.99 -0.35 6.69e-9 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07862083 chr17:21187823 MAP2K3 0.56 6.74 0.38 9.69e-11 Gut microbiome composition (summer); CESC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg12564285 chr5:131593104 PDLIM4 0.38 5.85 0.34 1.43e-8 Breast cancer; CESC cis rs854765 0.619 rs6502636 chr17:17983817 A/T cg04398451 chr17:18023971 MYO15A -0.77 -11.34 -0.57 1.48e-24 Total body bone mineral density; CESC cis rs6580649 0.941 rs4760683 chr12:48516296 T/C cg05342945 chr12:48394962 COL2A1 0.5 5.87 0.34 1.28e-8 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07744562 chr6:90539506 CASP8AP2 0.55 6.25 0.36 1.61e-9 Gut microbiome composition (summer); CESC cis rs888194 0.568 rs10850137 chr12:109874794 C/G cg19025524 chr12:109796872 NA -0.37 -5.07 -0.3 7.64e-7 Neuroticism; CESC trans rs637571 0.522 rs1151512 chr11:65757533 G/A cg17712092 chr4:129076599 LARP1B 0.75 10.57 0.54 5.01e-22 Eosinophil percentage of white cells; CESC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg06028605 chr16:24865363 SLC5A11 0.55 8.24 0.45 7.88e-15 Intelligence (multi-trait analysis); CESC cis rs2109514 0.569 rs926200 chr7:116170195 T/A cg04696780 chr7:116139425 CAV2 -0.3 -5.22 -0.31 3.55e-7 Prevalent atrial fibrillation; CESC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg10691866 chr7:65817282 TPST1 -0.32 -5.44 -0.32 1.19e-7 Aortic root size; CESC cis rs911555 0.755 rs7147664 chr14:103963420 G/A cg12935359 chr14:103987150 CKB -0.59 -8.46 -0.46 1.8e-15 Intelligence (multi-trait analysis); CESC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg19163074 chr7:65112434 INTS4L2 0.46 5.66 0.33 3.89e-8 Calcium levels; CESC cis rs4780401 0.609 rs9924522 chr16:11816852 C/A cg01061890 chr16:11836724 TXNDC11 -0.56 -7.52 -0.42 8.36e-13 Rheumatoid arthritis; CESC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.08 0.3 7.17e-7 Menopause (age at onset); CESC cis rs2295499 0.754 rs16843272 chr4:2717515 G/A cg08330972 chr4:2403930 ZFYVE28 -0.33 -5.42 -0.32 1.35e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06494227 chr22:30752758 CCDC157;SF3A1 -0.51 -6.66 -0.38 1.55e-10 Fibrinogen levels; CESC cis rs9640161 0.789 rs2098053 chr7:150043205 G/A cg21361702 chr7:150065534 REPIN1 0.57 6.01 0.35 6.25e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs11696501 0.688 rs6104291 chr20:44323368 C/G cg11783356 chr20:44313418 WFDC10B -0.31 -5.08 -0.3 7.02e-7 Brain structure; CESC cis rs2243480 1.000 rs34702770 chr7:65344823 T/C cg12463550 chr7:65579703 CRCP 0.68 5.61 0.33 5.08e-8 Diabetic kidney disease; CESC cis rs4423214 0.625 rs78685409 chr11:71137383 T/C cg05163923 chr11:71159392 DHCR7 -0.66 -7.65 -0.43 3.63e-13 Vitamin D levels; CESC cis rs7605827 0.897 rs6745621 chr2:15537866 C/A cg19274914 chr2:15703543 NA 0.36 6.4 0.37 7.05e-10 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20835789 chr3:15469053 METTL6;EAF1 0.58 6.7 0.38 1.23e-10 Gut microbiome composition (summer); CESC trans rs208520 1.000 rs12191598 chr6:66983962 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.33 0.5 4.5e-18 Exhaled nitric oxide output; CESC cis rs910316 0.763 rs175036 chr14:75464295 C/T cg08847533 chr14:75593920 NEK9 -0.9 -15.84 -0.7 3.34e-40 Height; CESC trans rs9858542 0.953 rs11926781 chr3:49603289 C/T cg21659725 chr3:3221576 CRBN -0.53 -6.52 -0.37 3.49e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg11890956 chr21:40555474 PSMG1 0.9 9.61 0.51 5.85e-19 Cognitive function; CESC cis rs6674176 0.597 rs6671164 chr1:44403489 G/T cg13606994 chr1:44402422 ARTN -0.39 -6.09 -0.35 3.99e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs258892 0.947 rs62360681 chr5:72187013 T/G cg21869765 chr5:72125136 TNPO1 0.45 5.62 0.33 4.9e-8 Small cell lung carcinoma; CESC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg08968635 chr6:28129556 ZNF389 0.41 5.51 0.32 8.4e-8 Depression; CESC cis rs11864453 0.826 rs2074627 chr16:72136769 C/T cg01557791 chr16:72042693 DHODH -0.51 -6.66 -0.38 1.54e-10 Fibrinogen levels; CESC cis rs6912958 0.559 rs107690 chr6:88069352 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -5.8 -0.34 1.84e-8 Monocyte percentage of white cells; CESC cis rs1707322 0.685 rs28617418 chr1:46189526 T/A cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs72781680 0.898 rs72798049 chr2:23958002 C/G cg20701182 chr2:24300061 SF3B14 0.62 5.49 0.32 9.46e-8 Lymphocyte counts; CESC cis rs3812762 0.879 rs10743088 chr11:8787620 A/C cg03980550 chr11:8754370 ST5 0.36 5.15 0.3 5.15e-7 Hypospadias; CESC cis rs897984 0.542 rs4468641 chr16:31096876 A/C cg00531865 chr16:30841666 NA -0.39 -5.47 -0.32 1.06e-7 Dementia with Lewy bodies; CESC cis rs35110281 0.591 rs162390 chr21:44936826 C/T cg21573476 chr21:45109991 RRP1B -0.39 -5.6 -0.33 5.44e-8 Mean corpuscular volume; CESC cis rs193541 0.545 rs12518979 chr5:122181787 G/T cg19412675 chr5:122181750 SNX24 -0.42 -5.08 -0.3 7.02e-7 Glucose homeostasis traits; CESC cis rs1256061 0.603 rs960069 chr14:64745002 C/T cg21174375 chr14:64681225 SYNE2 0.53 7.15 0.4 8.45e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.1 0.4 1.15e-11 Height; CESC cis rs344364 0.511 rs1742395 chr16:1955965 G/A cg03013636 chr16:1946785 NA 0.44 6.1 0.35 3.76e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs10463316 0.862 rs11740475 chr5:150777997 A/G cg03212797 chr5:150827313 SLC36A1 -0.43 -5.61 -0.33 5.12e-8 Metabolite levels (Pyroglutamine); CESC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.26 0.31 3e-7 Menopause (age at onset); CESC cis rs147649347 1 rs147649347 chr2:24210076 GATAA/G cg20701182 chr2:24300061 SF3B14 0.69 6.07 0.35 4.35e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg19626725 chr5:178986131 RUFY1 0.39 6.37 0.36 8.51e-10 Lung cancer; CESC cis rs854765 0.534 rs7207461 chr17:17949789 T/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.73 -0.47 2.97e-16 Total body bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg27556566 chr18:29671984 RNF138 0.54 7.25 0.41 4.51e-12 Gut microbiota (bacterial taxa); CESC cis rs9309711 0.736 rs9309717 chr2:3495078 C/T cg10845886 chr2:3471009 TTC15 0.66 8.89 0.48 9.47e-17 Neurofibrillary tangles; CESC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg18876405 chr7:65276391 NA -0.53 -7.3 -0.41 3.28e-12 Aortic root size; CESC cis rs992157 0.764 rs4672886 chr2:219185545 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.59 -7.86 -0.43 9.93e-14 Colorectal cancer; CESC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.04 0.3 8.57e-7 Life satisfaction; CESC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg19163074 chr7:65112434 INTS4L2 -0.46 -5.05 -0.3 8.07e-7 Aortic root size; CESC cis rs11792861 0.525 rs2417975 chr9:111860185 A/C cg05043794 chr9:111880884 C9orf5 -0.28 -5.07 -0.3 7.57e-7 Menarche (age at onset); CESC cis rs3820928 0.967 rs12622456 chr2:227768868 G/A cg05526886 chr2:227700861 RHBDD1 -0.44 -5.61 -0.33 4.97e-8 Pulmonary function; CESC cis rs7605827 0.897 rs10166702 chr2:15528454 T/C cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs2286503 0.752 rs6461669 chr7:22858066 T/G cg11367502 chr7:22862612 TOMM7 0.41 5.45 0.32 1.16e-7 Fibrinogen; CESC cis rs9911578 1.000 rs4398153 chr17:56968181 T/C cg12560992 chr17:57184187 TRIM37 -0.92 -15.0 -0.68 3.02e-37 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg05368731 chr17:41323189 NBR1 0.76 10.35 0.54 2.73e-21 Menopause (age at onset); CESC cis rs1278769 1.000 rs1278769 chr13:113536627 C/T cg00823993 chr13:113535758 ATP11A 0.47 6.27 0.36 1.49e-9 Interstitial lung disease; CESC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg19592336 chr6:28129416 ZNF389 0.47 6.86 0.39 4.78e-11 Cardiac Troponin-T levels; CESC cis rs1448094 0.511 rs17279133 chr12:86162353 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.59 0.32 5.75e-8 Major depressive disorder; CESC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg11663144 chr21:46675770 NA -0.63 -9.96 -0.52 4.67e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2731664 0.792 rs2630765 chr5:176876825 T/C cg23176889 chr5:176863531 GRK6 -0.64 -11.06 -0.56 1.22e-23 Intelligence (multi-trait analysis); CESC cis rs2795502 0.873 rs3121327 chr10:43388285 G/A cg27426351 chr10:43362370 NA 0.49 6.0 0.35 6.55e-9 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15236340 chr19:52838590 ZNF610 0.48 6.44 0.37 5.48e-10 Fibrinogen levels; CESC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg14893161 chr1:205819251 PM20D1 0.87 15.34 0.69 1.9e-38 Menarche (age at onset); CESC cis rs6088590 1.000 rs6088607 chr20:33378733 C/T cg08999081 chr20:33150536 PIGU 0.58 8.9 0.48 9.32e-17 Coronary artery disease; CESC cis rs62103177 0.713 rs62103186 chr18:77627574 G/C cg12964065 chr18:77638022 KCNG2 0.58 5.46 0.32 1.07e-7 Opioid sensitivity; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24582500 chr10:131934763 GLRX3 0.43 6.01 0.35 6.19e-9 Gut microbiota (bacterial taxa); CESC trans rs75107833 0.580 rs6433464 chr2:175008772 C/T cg22524735 chr8:144779094 BREA2 -0.44 -6.13 -0.35 3.2e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes;Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9522267 0.535 rs9515453 chr13:112234612 T/C cg10483660 chr13:112241077 NA -0.33 -5.79 -0.33 2.04e-8 Hepatitis; CESC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.56 0.37 2.89e-10 Prudent dietary pattern; CESC cis rs1670533 1.000 rs7685541 chr4:1058501 G/A cg27284194 chr4:1044797 NA 0.48 6.1 0.35 3.7e-9 Recombination rate (females); CESC cis rs3750965 1.000 rs731974 chr11:68847156 C/T cg01403660 chr11:68851641 TPCN2 0.39 5.11 0.3 6.25e-7 Hair color; CESC cis rs748404 0.631 rs2412781 chr15:43667900 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.59 -7.63 -0.42 4.32e-13 Lung cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11649068 chr17:34136647 TAF15 -0.47 -6.3 -0.36 1.25e-9 Ulcerative colitis; CESC cis rs921968 0.541 rs7583449 chr2:219403022 A/C cg02176678 chr2:219576539 TTLL4 -0.53 -9.38 -0.5 3.15e-18 Mean corpuscular hemoglobin concentration; CESC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg26408565 chr15:76604113 ETFA -0.42 -6.25 -0.36 1.61e-9 Blood metabolite levels; CESC trans rs2235573 0.527 rs139878 chr22:38361559 C/T cg19894588 chr14:64061835 NA 0.63 8.28 0.45 6.09e-15 Glioblastoma;Glioma; CESC cis rs10751667 0.666 rs7944815 chr11:959776 C/T cg06064525 chr11:970664 AP2A2 -0.47 -9.44 -0.5 2.07e-18 Alzheimer's disease (late onset); CESC cis rs12464559 0.649 rs12693116 chr2:152623917 A/G cg01189475 chr2:152685088 ARL5A 0.68 5.87 0.34 1.31e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs9303401 0.614 rs56284918 chr17:57178838 A/G cg12560992 chr17:57184187 TRIM37 0.5 5.21 0.3 3.78e-7 Cognitive test performance; CESC cis rs910316 1.000 rs12435391 chr14:75601737 A/G cg08847533 chr14:75593920 NEK9 0.99 19.05 0.76 1.47e-51 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03662217 chr21:35747882 FAM165B 0.51 6.62 0.38 1.98e-10 Gut microbiota (bacterial taxa); CESC cis rs7937682 1.000 rs505372 chr11:111507189 A/C cg09085632 chr11:111637200 PPP2R1B -0.98 -15.55 -0.69 3.35e-39 Primary sclerosing cholangitis; CESC cis rs6495122 0.699 rs1378941 chr15:75080150 C/A cg14664628 chr15:75095509 CSK -0.68 -9.37 -0.5 3.23e-18 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs2204008 0.659 rs4002655 chr12:38169881 T/G cg26384229 chr12:38710491 ALG10B 0.72 10.46 0.54 1.18e-21 Bladder cancer; CESC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg25427524 chr10:38739819 LOC399744 -0.72 -10.76 -0.55 1.23e-22 Extrinsic epigenetic age acceleration; CESC cis rs1355223 0.583 rs1553757 chr11:34867089 G/A cg11058730 chr11:34937778 PDHX;APIP 0.84 12.68 0.61 4.2e-29 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2072438 0.503 rs10739590 chr9:123871481 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.37 5.27 0.31 2.84e-7 Rheumatoid arthritis; CESC cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg01579765 chr21:45077557 HSF2BP -0.56 -9.75 -0.51 2.11e-19 Mean corpuscular volume; CESC cis rs17253792 0.818 rs78393484 chr14:56065802 T/C cg01858014 chr14:56050164 KTN1 -0.96 -7.13 -0.4 9.72e-12 Putamen volume; CESC cis rs7084402 0.967 rs1621227 chr10:60327734 C/G cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg15485101 chr11:133734466 NA 0.41 6.61 0.38 2.16e-10 Childhood ear infection; CESC cis rs6500602 0.561 rs62039231 chr16:4519548 A/G cg08645402 chr16:4508243 NA 0.57 8.97 0.48 5.57e-17 Schizophrenia; CESC cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg26769984 chr7:1090371 C7orf50 0.64 7.59 0.42 5.55e-13 Bronchopulmonary dysplasia; CESC cis rs2066819 1.000 rs76466034 chr12:56719450 G/A cg26714650 chr12:56694279 CS -1.48 -9.9 -0.52 7.03e-20 Psoriasis vulgaris; CESC cis rs7219021 0.705 rs7207087 chr17:46917953 C/G cg16584676 chr17:46985605 UBE2Z 0.57 6.98 0.39 2.32e-11 Schizophrenia or bipolar disorder; CESC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg07157834 chr1:205819609 PM20D1 0.4 5.62 0.33 4.72e-8 Menarche (age at onset); CESC trans rs3942852 0.568 rs6485807 chr11:48102867 G/A cg15704280 chr7:45808275 SEPT13 -0.72 -9.41 -0.5 2.58e-18 Acute lymphoblastic leukemia (childhood); CESC cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg25019033 chr10:957182 NA -0.52 -5.21 -0.3 3.81e-7 Eosinophil percentage of granulocytes; CESC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.2 0.3 4.08e-7 Electroencephalogram traits; CESC cis rs9910055 0.659 rs8079310 chr17:42270291 A/G cg13607699 chr17:42295918 UBTF 0.59 7.57 0.42 6.13e-13 Total body bone mineral density; CESC cis rs9300255 0.509 rs641760 chr12:123518866 T/C cg00376283 chr12:123451042 ABCB9 0.75 8.92 0.48 8.09e-17 Neutrophil percentage of white cells; CESC cis rs62432291 0.681 rs429339 chr6:159660148 C/T cg14500486 chr6:159655392 FNDC1 -0.62 -6.34 -0.36 9.83e-10 Joint mobility (Beighton score); CESC cis rs17401966 1.000 rs7530167 chr1:10453374 A/G cg15208524 chr1:10270712 KIF1B 0.46 5.8 0.34 1.86e-8 Hepatocellular carcinoma; CESC cis rs6693567 0.545 rs11205375 chr1:150412474 C/T cg09579323 chr1:150459698 TARS2 0.48 6.08 0.35 4.13e-9 Migraine; CESC cis rs2204008 0.616 rs1607852 chr12:38398125 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.41 0.54 1.74e-21 Bladder cancer; CESC cis rs1020064 0.636 rs2679876 chr2:105938107 T/C cg02079111 chr2:105885981 TGFBRAP1 0.37 5.12 0.3 5.88e-7 AIDS; CESC cis rs12142240 0.698 rs9661240 chr1:46827050 G/A cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC trans rs3960554 1.000 rs2097947 chr7:75836382 A/T cg19862616 chr7:65841803 NCRNA00174 0.52 6.05 0.35 4.89e-9 Eotaxin levels; CESC cis rs6088590 0.561 rs6059926 chr20:33164804 C/T cg06115741 chr20:33292138 TP53INP2 0.51 6.51 0.37 3.74e-10 Coronary artery disease; CESC cis rs9457247 0.663 rs2282860 chr6:167440244 T/C cg07741184 chr6:167504864 NA 0.34 6.09 0.35 3.9e-9 Crohn's disease; CESC cis rs12079745 0.793 rs3766052 chr1:169126031 A/T cg09363564 chr1:169337483 NME7;BLZF1 -1.18 -6.95 -0.39 2.85e-11 QT interval; CESC cis rs11098499 0.909 rs10026736 chr4:120384322 G/C cg24375607 chr4:120327624 NA 0.48 5.87 0.34 1.33e-8 Corneal astigmatism; CESC cis rs9905704 0.647 rs6503892 chr17:57067086 G/A cg12560992 chr17:57184187 TRIM37 0.65 8.05 0.44 2.8e-14 Testicular germ cell tumor; CESC cis rs2180341 0.961 rs3798857 chr6:127659473 A/T cg24812749 chr6:127587940 RNF146 1.07 15.4 0.69 1.16e-38 Breast cancer; CESC cis rs829661 0.532 rs12621663 chr2:30784540 G/A cg12454169 chr2:30669597 LCLAT1 -0.4 -5.03 -0.3 9.16e-7 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs6964587 1.000 rs7784248 chr7:91758111 A/G cg17063962 chr7:91808500 NA 0.58 7.97 0.44 4.71e-14 Breast cancer; CESC cis rs10256972 0.527 rs2949170 chr7:1216438 A/G cg04025307 chr7:1156635 C7orf50 0.57 9.29 0.5 5.65e-18 Longevity;Endometriosis; CESC cis rs524281 0.861 rs6591207 chr11:65949674 A/T cg14036092 chr11:66035641 RAB1B -0.56 -5.85 -0.34 1.45e-8 Electroencephalogram traits; CESC cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs9660992 0.736 rs72745207 chr1:205251991 C/G cg21643547 chr1:205240462 TMCC2 -0.46 -6.14 -0.35 3e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs4919694 1.000 rs4917379 chr10:104752831 A/T cg04362960 chr10:104952993 NT5C2 0.74 6.44 0.37 5.71e-10 Arsenic metabolism; CESC cis rs30380 0.632 rs27045 chr5:96138861 C/T cg16492584 chr5:96139282 ERAP1 -0.49 -6.76 -0.38 8.56e-11 Cerebrospinal fluid biomarker levels; CESC cis rs3733585 0.563 rs881971 chr4:9930962 A/G cg00071950 chr4:10020882 SLC2A9 -0.65 -10.59 -0.55 4.47e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8067545 1.000 rs4925065 chr17:19914546 C/T cg13482628 chr17:19912719 NA 0.46 6.17 0.35 2.55e-9 Schizophrenia; CESC cis rs17376456 0.778 rs10476604 chr5:93461838 C/T cg25358565 chr5:93447407 FAM172A 0.53 6.22 0.36 1.98e-9 Diabetic retinopathy; CESC cis rs6496667 0.533 rs886491 chr15:90993215 G/A cg10434728 chr15:90938212 IQGAP1 0.31 5.45 0.32 1.13e-7 Rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17114847 chr11:47736795 AGBL2 0.53 6.25 0.36 1.63e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg03467027 chr4:99064603 C4orf37 0.49 6.06 0.35 4.55e-9 Colonoscopy-negative controls vs population controls; CESC cis rs910316 1.000 rs876402 chr14:75601862 C/T cg16144293 chr14:75469539 EIF2B2 0.41 5.31 0.31 2.32e-7 Height; CESC cis rs6761276 0.649 rs3811057 chr2:113831188 C/A cg12858261 chr2:113808755 IL1F8 0.46 5.68 0.33 3.63e-8 Protein quantitative trait loci; CESC cis rs14403 0.913 rs12042298 chr1:243651806 C/T cg21452805 chr1:244014465 NA 0.45 5.09 0.3 6.88e-7 Schizophrenia; CESC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.25 -0.36 1.67e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12824058 0.831 rs4759658 chr12:130815872 C/T cg23887609 chr12:130822674 PIWIL1 0.45 5.86 0.34 1.38e-8 Menopause (age at onset); CESC cis rs7617480 0.558 rs12715430 chr3:48942855 A/C cg07636037 chr3:49044803 WDR6 0.85 11.57 0.58 2.46e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs1023500 0.505 rs134888 chr22:42674281 C/T cg04733989 chr22:42467013 NAGA 0.64 9.8 0.52 1.53e-19 Schizophrenia; CESC cis rs11122272 0.735 rs2486728 chr1:231535883 T/G cg06096015 chr1:231504339 EGLN1 0.43 6.08 0.35 4.22e-9 Hemoglobin concentration; CESC cis rs6539267 0.847 rs17217845 chr12:106697802 C/T cg00173435 chr12:106696525 TCP11L2 -0.62 -6.36 -0.36 9.01e-10 Tourette syndrome; CESC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg02462569 chr6:150064036 NUP43 -0.38 -5.46 -0.32 1.11e-7 Lung cancer; CESC cis rs9581857 0.685 rs9581856 chr13:28025615 G/C cg22138327 chr13:27999177 GTF3A 0.64 5.14 0.3 5.37e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22215202 chr19:50321460 MED25 -0.54 -6.03 -0.35 5.36e-9 Gut microbiome composition (summer); CESC cis rs6893300 0.776 rs56396231 chr5:179157298 T/G cg14593053 chr5:179126677 CANX -0.47 -5.15 -0.3 5.1e-7 Resting heart rate; CESC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs34172651 0.917 rs6497760 chr16:24806535 G/A cg06028605 chr16:24865363 SLC5A11 0.41 6.22 0.36 1.94e-9 Intelligence (multi-trait analysis); CESC cis rs3087591 0.922 rs2341348 chr17:29534867 C/T cg24425628 chr17:29625626 OMG;NF1 0.42 5.03 0.3 9.22e-7 Hip circumference; CESC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg00784671 chr22:46762841 CELSR1 -0.52 -5.49 -0.32 9.2e-8 LDL cholesterol;Cholesterol, total; CESC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg04317338 chr11:64019027 PLCB3 0.54 6.47 0.37 4.65e-10 Platelet count; CESC cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.36 0.31 1.79e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg17366294 chr4:99064904 C4orf37 0.55 7.14 0.4 9.06e-12 Colonoscopy-negative controls vs population controls; CESC cis rs7178572 0.568 rs8030074 chr15:77654232 C/T cg22256960 chr15:77711686 NA -0.53 -6.79 -0.38 7.53e-11 Type 2 diabetes; CESC cis rs17376456 0.825 rs13165400 chr5:93091427 G/A cg25358565 chr5:93447407 FAM172A 1.1 10.54 0.54 6.5e-22 Diabetic retinopathy; CESC cis rs35110281 0.501 rs162378 chr21:44925905 A/G cg01579765 chr21:45077557 HSF2BP 0.38 6.19 0.36 2.27e-9 Mean corpuscular volume; CESC cis rs1847202 0.793 rs13088835 chr3:72949861 A/T cg25664220 chr3:72788482 NA -0.38 -5.52 -0.32 8.08e-8 Motion sickness; CESC cis rs11792861 0.888 rs75543406 chr9:111816903 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 5.62 0.33 4.83e-8 Menarche (age at onset); CESC cis rs9325144 0.560 rs6582561 chr12:38666821 G/A cg26384229 chr12:38710491 ALG10B -0.6 -8.49 -0.46 1.45e-15 Morning vs. evening chronotype; CESC cis rs7845219 0.525 rs7820818 chr8:95919231 G/A cg13393036 chr8:95962371 TP53INP1 -0.43 -7.98 -0.44 4.45e-14 Type 2 diabetes; CESC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs9913156 0.670 rs4470203 chr17:4567798 G/A cg19197139 chr17:4613644 ARRB2 -0.72 -8.78 -0.47 2.03e-16 Lymphocyte counts; CESC trans rs61931739 0.571 rs4001689 chr12:34243271 C/T cg26384229 chr12:38710491 ALG10B 0.63 9.2 0.49 1.11e-17 Morning vs. evening chronotype; CESC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs7605827 0.897 rs6708187 chr2:15684964 T/A cg19274914 chr2:15703543 NA 0.36 6.39 0.37 7.29e-10 Educational attainment (years of education); CESC cis rs7089973 0.604 rs11196952 chr10:116607592 G/A cg25233709 chr10:116636983 FAM160B1 0.38 6.08 0.35 4.13e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1153858 0.887 rs28569043 chr15:45730926 A/T cg14582100 chr15:45693742 SPATA5L1 0.37 5.04 0.3 8.53e-7 Homoarginine levels; CESC cis rs3749237 0.595 rs4855873 chr3:49459114 A/C cg02487422 chr3:49467188 NICN1 0.57 8.34 0.46 4.01e-15 Resting heart rate; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19458608 chr3:129830607 LOC729375 -0.48 -6.31 -0.36 1.14e-9 Asthma; CESC cis rs34779708 0.931 rs12767414 chr10:35390193 C/T cg03585969 chr10:35415529 CREM 0.77 10.11 0.53 1.53e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs72781680 0.898 rs72786288 chr2:24075416 G/T cg08917208 chr2:24149416 ATAD2B 0.93 8.48 0.46 1.57e-15 Lymphocyte counts; CESC cis rs6963495 0.818 rs116845562 chr7:105217038 T/C cg19920283 chr7:105172520 RINT1 0.65 6.0 0.35 6.53e-9 Bipolar disorder (body mass index interaction); CESC cis rs787274 0.867 rs786981 chr9:115457856 T/G cg13803584 chr9:115635662 SNX30 0.54 5.21 0.3 3.83e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9512730 0.527 rs11619722 chr13:27998600 T/C cg04070771 chr13:27998621 GTF3A 0.51 5.5 0.32 9.11e-8 Schizophrenia; CESC cis rs10883723 0.703 rs7898410 chr10:104245858 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.56 0.42 6.77e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs1153858 0.943 rs28605551 chr15:45641720 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7799006 0.964 rs3757440 chr7:2272936 A/G cg12745145 chr7:2261452 MAD1L1 -0.34 -5.31 -0.31 2.34e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6456156 0.586 rs1358882 chr6:167467101 G/A cg07741184 chr6:167504864 NA 0.35 6.08 0.35 4.1e-9 Primary biliary cholangitis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg27254601 chr16:29817104 MAZ -0.49 -6.64 -0.38 1.79e-10 Asthma; CESC cis rs10129255 0.957 rs10150241 chr14:107184184 A/T cg23076370 chr14:107095027 NA 0.44 5.83 0.34 1.62e-8 Kawasaki disease; CESC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.53 6.37 0.36 8.31e-10 Breast cancer; CESC cis rs208520 0.690 rs12194057 chr6:66745616 A/G cg07460842 chr6:66804631 NA 0.96 12.69 0.61 3.81e-29 Exhaled nitric oxide output; CESC trans rs7246657 0.943 rs3745765 chr19:37854235 G/T cg24637308 chr11:6592297 DNHD1 0.52 6.08 0.35 4.27e-9 Coronary artery calcification; CESC cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg11752832 chr7:134001865 SLC35B4 0.52 6.71 0.38 1.2e-10 Mean platelet volume; CESC cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11711311 1.000 rs2603792 chr3:113509187 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.56 7.39 0.41 1.92e-12 IgG glycosylation; CESC cis rs11148252 0.595 rs9526968 chr13:53240183 T/C cg00495681 chr13:53174319 NA 0.6 8.21 0.45 9.62e-15 Lewy body disease; CESC cis rs6942756 0.915 rs6946938 chr7:129004662 A/C cg02491457 chr7:128862824 NA -0.6 -8.39 -0.46 2.99e-15 White matter hyperintensity burden; CESC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg27165867 chr14:105738592 BRF1 -0.52 -5.66 -0.33 3.92e-8 Mean platelet volume;Platelet distribution width; CESC cis rs2635047 0.713 rs17723389 chr18:44762307 C/T cg24371990 chr18:44770781 NA 0.41 6.68 0.38 1.38e-10 Educational attainment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09692677 chr20:34359756 PHF20 -0.52 -6.32 -0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg16447950 chr5:562315 NA -0.58 -6.05 -0.35 4.93e-9 Lung disease severity in cystic fibrosis; CESC cis rs6942756 0.668 rs644723 chr7:129107881 C/T cg02491457 chr7:128862824 NA -0.58 -8.07 -0.44 2.53e-14 White matter hyperintensity burden; CESC cis rs9905704 0.708 rs304263 chr17:56749941 C/T cg12560992 chr17:57184187 TRIM37 0.61 7.69 0.43 2.92e-13 Testicular germ cell tumor; CESC cis rs17666538 0.710 rs12716640 chr8:645376 A/C cg02524346 chr8:600233 NA 0.84 7.22 0.41 5.49e-12 IgG glycosylation; CESC cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.52 8.88 0.48 1.06e-16 Monocyte percentage of white cells; CESC cis rs3806843 1.000 rs13157397 chr5:140184442 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.1 -0.3 6.55e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1003719 0.788 rs2835579 chr21:38457965 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.67 0.47 4.41e-16 Eye color traits; CESC cis rs1003719 0.843 rs1003721 chr21:38492657 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 7.94 0.44 5.87e-14 Eye color traits; CESC cis rs6693567 0.545 rs1260385 chr1:150316385 G/A cg09579323 chr1:150459698 TARS2 0.5 6.24 0.36 1.75e-9 Migraine; CESC cis rs7980687 0.527 rs1727295 chr12:123616861 G/A cg05973401 chr12:123451056 ABCB9 0.56 7.04 0.4 1.65e-11 Height;Educational attainment;Head circumference (infant); CESC cis rs16854884 0.657 rs6778627 chr3:143720869 G/T cg06585982 chr3:143692056 C3orf58 0.45 5.82 0.34 1.71e-8 Economic and political preferences (feminism/equality); CESC cis rs1707322 0.963 rs10890371 chr1:46390897 T/G cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6499255 0.951 rs12596823 chr16:69634757 A/C cg15192750 chr16:69999425 NA 0.5 5.77 0.33 2.22e-8 IgE levels; CESC cis rs34638657 0.687 rs2303265 chr16:82203705 A/C cg09439754 chr16:82129088 HSD17B2 -0.36 -6.36 -0.36 8.85e-10 Lung adenocarcinoma; CESC cis rs2625529 0.824 rs4777475 chr15:72218206 C/T cg16672083 chr15:72433130 SENP8 -0.4 -5.26 -0.31 3.04e-7 Red blood cell count; CESC cis rs1707322 0.686 rs2230659 chr1:46078884 C/T cg05343316 chr1:45956843 TESK2 -0.53 -6.45 -0.37 5.42e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7937682 0.632 rs14133 chr11:111782697 C/G cg09085632 chr11:111637200 PPP2R1B 0.87 11.25 0.57 2.88e-24 Primary sclerosing cholangitis; CESC cis rs2108622 0.727 rs8104311 chr19:15982760 T/C cg13772218 chr19:15982569 NA 0.29 5.67 0.33 3.8e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26774059 chr17:26684261 POLDIP2;TMEM199 -0.45 -6.01 -0.35 6.24e-9 Fibrinogen levels; CESC cis rs77741769 0.571 rs35905305 chr12:121328082 T/G cg02419362 chr12:121203948 SPPL3 0.34 5.53 0.32 7.55e-8 Mean corpuscular volume; CESC cis rs854765 0.547 rs2955383 chr17:17941364 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.27 0.41 4.15e-12 Total body bone mineral density; CESC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg24399712 chr22:39784796 NA -0.81 -10.81 -0.55 8.51e-23 Intelligence (multi-trait analysis); CESC cis rs796364 0.806 rs6435040 chr2:200861161 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 7.7 0.43 2.79e-13 Schizophrenia; CESC cis rs9291683 0.507 rs6845554 chr4:10013173 T/G cg02734326 chr4:10020555 SLC2A9 0.42 5.77 0.33 2.27e-8 Bone mineral density; CESC cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg10556349 chr10:835070 NA 0.58 5.48 0.32 9.7e-8 Eosinophil percentage of granulocytes; CESC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.49 0.42 1.01e-12 Prudent dietary pattern; CESC cis rs1729951 0.575 rs16844326 chr3:136678385 G/C cg04103450 chr3:136751342 NA 0.4 5.28 0.31 2.66e-7 Neuroticism; CESC cis rs17376456 0.569 rs11135397 chr5:93214975 G/T cg25358565 chr5:93447407 FAM172A 0.66 7.24 0.41 4.82e-12 Diabetic retinopathy; CESC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg26343298 chr8:95960752 TP53INP1 0.32 5.28 0.31 2.74e-7 Type 2 diabetes; CESC cis rs77972916 0.611 rs61552842 chr2:43584036 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.57 -5.21 -0.3 3.89e-7 Granulocyte percentage of myeloid white cells; CESC cis rs561341 1.000 rs693116 chr17:30246124 C/T cg19193384 chr17:30244184 NA -0.7 -6.41 -0.37 6.77e-10 Hip circumference adjusted for BMI; CESC cis rs11690935 0.549 rs2129475 chr2:172916772 A/G cg13550731 chr2:172543902 DYNC1I2 0.5 6.77 0.38 8.32e-11 Schizophrenia; CESC cis rs1348850 1.000 rs1348850 chr2:178418575 A/G cg23306229 chr2:178417860 TTC30B 0.6 7.67 0.43 3.37e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg07343612 chr16:622815 PIGQ -0.55 -8.12 -0.45 1.81e-14 Height; CESC cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.720 rs11180923 chr12:38255172 A/T cg26384229 chr12:38710491 ALG10B 0.68 9.7 0.51 3.2e-19 Bladder cancer; CESC cis rs2777491 0.957 rs16971798 chr15:41657144 A/T cg02330683 chr15:41787940 ITPKA -0.44 -6.57 -0.37 2.69e-10 Ulcerative colitis; CESC cis rs6499755 0.712 rs31087 chr16:55363238 G/A cg02859129 chr16:55357253 IRX6 0.32 5.04 0.3 8.43e-7 Hypospadias; CESC cis rs9649465 1.000 rs9649465 chr7:123376560 G/A cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.46e-7 Migraine; CESC cis rs941408 0.515 rs1736188 chr19:2782368 A/G cg02580895 chr19:2754563 NA -0.48 -6.7 -0.38 1.25e-10 Total cholesterol levels; CESC cis rs2635047 0.875 rs2251948 chr18:44681356 A/T cg19077165 chr18:44547161 KATNAL2 -0.44 -5.93 -0.34 9.55e-9 Educational attainment; CESC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg18180107 chr4:99064573 C4orf37 0.46 5.7 0.33 3.18e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13444131 chr19:40322546 DYRK1B -0.67 -7.68 -0.43 3.13e-13 Gut microbiome composition (summer); CESC cis rs2250402 0.510 rs7535 chr15:40328575 G/C cg20255370 chr15:40268687 EIF2AK4 -0.58 -5.22 -0.31 3.54e-7 Corneal curvature; CESC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg16325326 chr1:53192061 ZYG11B -0.89 -15.22 -0.68 5.28e-38 Monocyte count; CESC cis rs1348850 0.597 rs4893964 chr2:178447658 G/T cg23306229 chr2:178417860 TTC30B 0.68 7.48 0.42 1.1e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs911555 0.574 rs34251103 chr14:103860063 A/G cg12935359 chr14:103987150 CKB 0.61 8.74 0.47 2.75e-16 Intelligence (multi-trait analysis); CESC trans rs61931739 0.500 rs9705909 chr12:34576419 G/C cg26384229 chr12:38710491 ALG10B 0.73 10.92 0.56 3.54e-23 Morning vs. evening chronotype; CESC cis rs2933343 0.621 rs789241 chr3:128585752 G/A cg25356066 chr3:128598488 ACAD9 0.59 8.35 0.46 3.8e-15 IgG glycosylation; CESC cis rs1044826 0.619 rs57357132 chr3:139118358 A/T cg00490450 chr3:139108681 COPB2 -0.42 -5.2 -0.3 4.03e-7 Obesity-related traits; CESC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg02487422 chr3:49467188 NICN1 0.41 5.39 0.31 1.55e-7 Parkinson's disease; CESC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg22029157 chr1:209979665 IRF6 0.5 7.91 0.44 6.88e-14 Monobrow; CESC cis rs4664304 0.754 rs67504285 chr2:160821211 C/T cg03641300 chr2:160917029 PLA2R1 -0.41 -5.59 -0.33 5.5e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg03709012 chr19:19516395 GATAD2A 0.95 13.98 0.65 1.22e-33 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00387107 chr7:101845057 CUX1 0.5 6.46 0.37 4.85e-10 Fibrinogen levels; CESC trans rs11148252 0.553 rs9536236 chr13:53255012 T/A cg18335740 chr13:41363409 SLC25A15 0.5 6.74 0.38 9.72e-11 Lewy body disease; CESC cis rs8049634 0.528 rs3785017 chr16:84093931 A/G cg06572904 chr16:84086012 NA -0.47 -5.13 -0.3 5.65e-7 Small cell lung carcinoma; CESC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg11663144 chr21:46675770 NA -0.48 -7.32 -0.41 3e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs72634258 0.554 rs12741937 chr1:7897622 A/T cg26816564 chr1:7831052 VAMP3 0.61 5.31 0.31 2.35e-7 Inflammatory bowel disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03108344 chr6:150326762 RAET1K -0.47 -6.2 -0.36 2.14e-9 Ulcerative colitis; CESC cis rs10465746 0.740 rs1536165 chr1:84465073 C/A cg10977910 chr1:84465055 TTLL7 0.41 5.08 0.3 6.98e-7 Obesity-related traits; CESC cis rs595982 0.527 rs73061658 chr19:49372376 G/C cg15549821 chr19:49342101 PLEKHA4 -0.65 -6.96 -0.39 2.63e-11 Red cell distribution width; CESC cis rs9362426 0.943 rs7744338 chr6:88101999 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.52 5.94 0.34 8.78e-9 Depressive episodes in bipolar disorder; CESC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg24829409 chr8:58192753 C8orf71 -0.5 -6.89 -0.39 4.16e-11 Developmental language disorder (linguistic errors); CESC cis rs9911578 1.000 rs172565 chr17:56808996 A/T cg12560992 chr17:57184187 TRIM37 0.93 15.6 0.69 2.28e-39 Intelligence (multi-trait analysis); CESC cis rs6835098 1.000 rs10027708 chr4:174083116 T/C cg08422745 chr4:174089978 GALNT7 -0.83 -11.79 -0.59 4.45e-26 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs6430585 0.528 rs309162 chr2:136690783 T/A cg07169764 chr2:136633963 MCM6 1.16 17.03 0.72 1.95e-44 Corneal structure; CESC cis rs2732480 0.500 rs11168468 chr12:48612465 C/T cg04545296 chr12:48745243 ZNF641 0.39 6.46 0.37 5.05e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs2115536 0.967 rs4778734 chr15:80210851 A/G cg11839771 chr15:80205821 ST20 -0.37 -5.37 -0.31 1.69e-7 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg16325326 chr1:53192061 ZYG11B 0.61 9.29 0.5 6.05e-18 Monocyte count; CESC cis rs4474465 0.688 rs10501429 chr11:78279790 T/G cg27205649 chr11:78285834 NARS2 0.48 6.08 0.35 4.1e-9 Alzheimer's disease (survival time); CESC cis rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13379408 chr18:11909052 MPPE1 0.4 5.31 0.31 2.32e-7 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.21 0.63 5.81e-31 Prudent dietary pattern; CESC cis rs77956314 0.901 rs12310299 chr12:117335487 C/G cg02017074 chr12:117425053 FBXW8 -0.54 -5.14 -0.3 5.44e-7 Subcortical brain region volumes;Hippocampal volume; CESC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg10053473 chr17:62856997 LRRC37A3 0.65 7.26 0.41 4.26e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10870270 1.000 rs7898755 chr10:133777122 G/A cg17892150 chr10:133769511 PPP2R2D -0.86 -12.56 -0.61 1.08e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs3767633 0.925 rs2055539 chr1:161807866 T/C cg09175582 chr1:161736000 ATF6 0.86 6.88 0.39 4.23e-11 IgG glycosylation; CESC cis rs9926296 0.643 rs12596429 chr16:89841374 T/C cg04287289 chr16:89883240 FANCA 0.59 7.87 0.44 9.24e-14 Vitiligo; CESC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg17971929 chr21:40555470 PSMG1 -0.86 -12.63 -0.61 6.28e-29 Cognitive function; CESC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg10691866 chr7:65817282 TPST1 0.31 5.32 0.31 2.25e-7 Aortic root size; CESC cis rs6582630 0.502 rs10880450 chr12:38440294 G/C cg26384229 chr12:38710491 ALG10B 0.65 9.69 0.51 3.43e-19 Drug-induced liver injury (flucloxacillin); CESC cis rs7746199 0.736 rs6904596 chr6:27491299 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.82 6.1 0.35 3.77e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs9355610 0.892 rs2247314 chr6:167370230 T/C cg23791538 chr6:167370224 RNASET2 0.68 9.7 0.51 3.05e-19 Graves' disease; CESC cis rs7927592 0.763 rs3740628 chr11:68381415 A/G cg16797656 chr11:68205561 LRP5 0.47 7.02 0.4 1.82e-11 Total body bone mineral density; CESC cis rs863345 0.625 rs10752626 chr1:158528118 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.89 -0.39 4.1e-11 Pneumococcal bacteremia; CESC cis rs36051895 0.632 rs7030853 chr9:5179002 C/T cg02405213 chr9:5042618 JAK2 -0.51 -6.56 -0.37 2.84e-10 Pediatric autoimmune diseases; CESC cis rs10129255 0.957 rs8019272 chr14:107192946 C/A cg07958169 chr14:107095056 NA -0.4 -5.5 -0.32 8.83e-8 Kawasaki disease; CESC cis rs11252926 0.931 rs4881399 chr10:567325 A/G cg08603382 chr10:743973 NA 0.56 7.27 0.41 3.95e-12 Psychosis in Alzheimer's disease; CESC cis rs6570726 0.967 rs1396648 chr6:145785248 C/A cg23711669 chr6:146136114 FBXO30 -0.72 -10.54 -0.54 6.39e-22 Lobe attachment (rater-scored or self-reported); CESC trans rs11098499 0.779 rs80242894 chr4:120375752 G/A cg25214090 chr10:38739885 LOC399744 0.69 9.79 0.52 1.64e-19 Corneal astigmatism; CESC cis rs1577917 0.958 rs11758508 chr6:86506878 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.43 5.68 0.33 3.47e-8 Response to antipsychotic treatment; CESC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg15605315 chr1:45957053 TESK2 0.43 5.45 0.32 1.15e-7 High light scatter reticulocyte count; CESC cis rs2228479 0.717 rs12917681 chr16:89810941 C/A cg00800038 chr16:89945340 TCF25 -0.72 -7.37 -0.41 2.14e-12 Skin colour saturation; CESC cis rs6032067 0.929 rs6032049 chr20:43825556 C/T cg10761708 chr20:43804764 PI3 0.53 6.39 0.37 7.37e-10 Blood protein levels; CESC cis rs7762018 0.655 rs11966349 chr6:170162537 A/G cg05834625 chr6:170176447 C6orf70 -0.49 -5.92 -0.34 9.71e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7605827 0.930 rs6431707 chr2:15638165 A/T cg19274914 chr2:15703543 NA 0.35 6.11 0.35 3.58e-9 Educational attainment (years of education); CESC cis rs7527798 0.592 rs11118360 chr1:207858586 G/A cg21110645 chr1:207815933 NA -0.31 -5.26 -0.31 2.95e-7 Erythrocyte sedimentation rate; CESC cis rs11785400 0.762 rs9694556 chr8:143727841 A/G cg24634471 chr8:143751801 JRK 0.45 5.68 0.33 3.52e-8 Schizophrenia; CESC cis rs9814567 0.762 rs13093893 chr3:134292131 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.49 6.1 0.35 3.68e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2472297 1.000 rs2472297 chr15:75027880 A/G cg09165964 chr15:75287851 SCAMP5 -0.48 -5.05 -0.3 8.21e-7 Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level);Coffee consumption (cups per day);Coffee consumption;Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level);Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio); CESC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg13798912 chr7:905769 UNC84A -0.56 -5.53 -0.32 7.82e-8 Cerebrospinal P-tau181p levels; CESC cis rs9915657 0.660 rs975772 chr17:70067810 T/G cg09344028 chr17:70110421 NA 0.39 7.2 0.4 6.15e-12 Thyroid hormone levels; CESC cis rs7223966 1.000 rs7223412 chr17:61808172 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.68 0.38 1.4e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1465370 0.682 rs6972781 chr7:130023179 A/G cg04743876 chr7:130013617 NA 0.3 5.62 0.33 4.94e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs8060686 0.545 rs78229587 chr16:68165243 T/C cg26727032 chr16:67993705 SLC12A4 -0.49 -5.41 -0.32 1.43e-7 HDL cholesterol;Metabolic syndrome; CESC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg00684032 chr4:1343700 KIAA1530 0.39 5.34 0.31 2e-7 Obesity-related traits; CESC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg11663144 chr21:46675770 NA -0.62 -9.82 -0.52 1.27e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1577917 0.876 rs12190735 chr6:86686467 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.86 -0.34 1.39e-8 Response to antipsychotic treatment; CESC trans rs1814175 0.587 rs847628 chr11:49927064 A/T cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs9287719 0.935 rs7600495 chr2:10739800 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC trans rs2207136 0.835 rs2746651 chr6:50839832 G/A cg06522515 chr3:184090630 THPO -0.35 -6.18 -0.35 2.43e-9 Myopia; CESC cis rs2204008 0.805 rs11180825 chr12:38242916 G/T cg26384229 chr12:38710491 ALG10B 0.71 10.11 0.53 1.52e-20 Bladder cancer; CESC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg02187348 chr16:89574699 SPG7 0.7 9.96 0.52 4.69e-20 Multiple myeloma (IgH translocation); CESC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg14829155 chr15:31115871 NA 0.76 10.65 0.55 2.8e-22 Huntington's disease progression; CESC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg00166722 chr3:10149974 C3orf24 0.48 6.1 0.35 3.66e-9 Alzheimer's disease; CESC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg12963246 chr6:28129442 ZNF389 0.43 6.31 0.36 1.15e-9 Cardiac Troponin-T levels; CESC cis rs2880765 0.835 rs11074276 chr15:86030363 C/A cg19183879 chr15:85880815 NA -0.25 -5.18 -0.3 4.49e-7 Coronary artery disease; CESC cis rs55882075 0.967 rs12656648 chr5:179152106 C/A cg14593053 chr5:179126677 CANX 0.46 5.99 0.35 6.83e-9 Monocyte percentage of white cells; CESC cis rs9875589 0.509 rs4685062 chr3:14066409 T/C cg19554555 chr3:13937349 NA -0.44 -5.6 -0.33 5.43e-8 Ovarian reserve; CESC cis rs10876993 0.890 rs2619441 chr12:58083015 C/A cg18357645 chr12:58087776 OS9 0.63 10.64 0.55 2.98e-22 Celiac disease or Rheumatoid arthritis; CESC cis rs909674 0.865 rs5757683 chr22:39850174 G/A cg11247378 chr22:39784982 NA -0.62 -8.78 -0.47 2.13e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs561341 1.000 rs8073186 chr17:30244956 T/C cg20587970 chr11:113659929 NA -0.97 -11.82 -0.59 3.47e-26 Hip circumference adjusted for BMI; CESC cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg10645314 chr2:3704589 ALLC -0.46 -5.18 -0.3 4.35e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg04455712 chr21:45112962 RRP1B 0.34 5.16 0.3 4.93e-7 Mean corpuscular volume; CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.76 0.38 9.02e-11 Cognitive function; CESC cis rs7851660 0.874 rs7847010 chr9:100630439 T/C cg13688889 chr9:100608707 NA -0.63 -8.8 -0.48 1.83e-16 Strep throat; CESC cis rs2797160 1.000 rs1954361 chr6:126001423 C/G cg05901451 chr6:126070800 HEY2 -0.45 -6.62 -0.38 1.97e-10 Endometrial cancer; CESC cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg09658497 chr7:2847517 GNA12 -0.33 -5.08 -0.3 7.14e-7 Height; CESC cis rs1215050 0.527 rs1214998 chr4:99042878 T/G cg17366294 chr4:99064904 C4orf37 0.45 5.86 0.34 1.38e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg04317338 chr11:64019027 PLCB3 0.92 10.01 0.52 3.13e-20 Mean platelet volume; CESC cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg03467027 chr4:99064603 C4orf37 0.42 5.17 0.3 4.61e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4722166 0.630 rs1829927 chr7:22779918 G/A cg05472934 chr7:22766657 IL6 0.87 10.94 0.56 3.06e-23 Lung cancer; CESC cis rs10129255 0.957 rs10150241 chr14:107184184 A/T cg07958169 chr14:107095056 NA 0.39 5.64 0.33 4.41e-8 Kawasaki disease; CESC cis rs2075371 0.611 rs62462979 chr7:134019379 G/T cg20476274 chr7:133979776 SLC35B4 0.53 7.3 0.41 3.4e-12 Mean platelet volume; CESC cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg23711669 chr6:146136114 FBXO30 -0.88 -13.21 -0.63 5.93e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg18446336 chr7:2847575 GNA12 -0.35 -5.38 -0.31 1.67e-7 Height; CESC cis rs7851660 0.935 rs10818124 chr9:100603008 C/T cg13688889 chr9:100608707 NA -0.68 -10.61 -0.55 3.8e-22 Strep throat; CESC cis rs8072100 0.807 rs2175290 chr17:45479917 C/A cg08085267 chr17:45401833 C17orf57 -0.54 -7.23 -0.41 5.13e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16504641 chr6:137143711 PEX7 -0.5 -6.31 -0.36 1.19e-9 Ulcerative colitis; CESC cis rs748404 0.660 rs2444251 chr15:43788595 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.5 0.42 9.94e-13 Lung cancer; CESC trans rs7746199 0.673 rs35501037 chr6:27739566 T/A cg06606381 chr12:133084897 FBRSL1 -1.05 -8.23 -0.45 8.53e-15 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs787274 0.718 rs4979170 chr9:115626918 C/G cg13803584 chr9:115635662 SNX30 0.56 5.04 0.3 8.55e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1790761 0.587 rs4930430 chr11:67294198 A/G cg08355456 chr11:67383691 NA 0.32 5.19 0.3 4.15e-7 Mean corpuscular volume; CESC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg09323728 chr8:95962352 TP53INP1 -0.38 -8.15 -0.45 1.49e-14 Type 2 diabetes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07791997 chr11:73882526 PPME1;C2CD3 -0.47 -6.38 -0.36 7.84e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2249694 0.960 rs9630033 chr10:135418505 G/T cg20169779 chr10:135381914 SYCE1 -0.4 -5.71 -0.33 3.1e-8 Obesity-related traits; CESC cis rs3739821 0.841 rs943392 chr9:130725441 A/G cg09665592 chr9:130699885 DPM2 0.48 5.08 0.3 6.97e-7 Glaucoma (primary angle closure); CESC cis rs2354432 0.607 rs894469 chr1:146672906 C/T cg25205988 chr1:146714368 CHD1L 1.19 9.08 0.49 2.58e-17 Mitochondrial DNA levels; CESC cis rs2075371 0.611 rs11762920 chr7:134018514 C/T cg11752832 chr7:134001865 SLC35B4 0.43 5.09 0.3 6.9e-7 Mean platelet volume; CESC cis rs6570726 0.791 rs6570695 chr6:145911286 C/A cg05347473 chr6:146136440 FBXO30 0.57 7.44 0.42 1.37e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2439831 1.000 rs689596 chr15:43761717 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.58 0.54 4.72e-22 Lung cancer in ever smokers; CESC cis rs854765 0.929 rs2955360 chr17:17974887 G/A cg04398451 chr17:18023971 MYO15A 0.67 9.65 0.51 4.44e-19 Total body bone mineral density; CESC cis rs2046867 0.818 rs17010215 chr3:72886965 A/G cg25664220 chr3:72788482 NA -0.46 -6.4 -0.37 7.09e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs6912958 0.967 rs9450688 chr6:88159276 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -7.58 -0.42 5.88e-13 Monocyte percentage of white cells; CESC cis rs7216064 1.000 rs55896768 chr17:65913358 T/C cg12091567 chr17:66097778 LOC651250 -0.7 -8.06 -0.44 2.55e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs28647808 0.881 rs4962047 chr9:136262916 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.84 5.72 0.33 2.87e-8 Blood protein levels; CESC cis rs2243480 1.000 rs73142166 chr7:65375832 A/G cg25894440 chr7:65020034 NA -0.64 -5.31 -0.31 2.33e-7 Diabetic kidney disease; CESC trans rs10463316 0.894 rs6891272 chr5:150762842 G/T cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs60154123 0.730 rs590380 chr1:210463071 C/T cg22029157 chr1:209979665 IRF6 0.44 5.19 0.3 4.17e-7 Coronary artery disease; CESC cis rs7107174 1.000 rs2450129 chr11:77940385 T/C cg02023728 chr11:77925099 USP35 0.48 6.81 0.39 6.61e-11 Testicular germ cell tumor; CESC cis rs17666538 0.585 rs10090260 chr8:608034 T/C cg26554054 chr8:600488 NA 0.65 5.2 0.3 3.96e-7 IgG glycosylation; CESC cis rs73206853 0.764 rs76142162 chr12:110884307 C/G cg12870014 chr12:110450643 ANKRD13A 0.63 5.18 0.3 4.34e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs3815700 1.000 rs7248845 chr19:33096718 T/C cg24916020 chr19:33096688 ANKRD27 0.6 6.04 0.35 5.09e-9 Eosinophilic esophagitis; CESC cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg22455342 chr2:225449267 CUL3 -0.71 -9.83 -0.52 1.19e-19 IgE levels in asthmatics (D.p. specific); CESC cis rs11098499 0.954 rs6849171 chr4:120409549 G/A cg09160332 chr4:120329925 NA -0.38 -5.12 -0.3 5.84e-7 Corneal astigmatism; CESC cis rs8028182 0.636 rs11634863 chr15:75766672 C/A cg20655648 chr15:75932815 IMP3 0.48 5.98 0.34 7.2e-9 Sudden cardiac arrest; CESC cis rs9399137 0.507 rs6940878 chr6:135366309 G/A cg24558204 chr6:135376177 HBS1L 0.66 8.97 0.48 5.56e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs1062177 0.826 rs2915873 chr5:151156658 G/A cg12924095 chr5:151150029 G3BP1 0.46 6.04 0.35 5.19e-9 Preschool internalizing problems; CESC cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg01579765 chr21:45077557 HSF2BP -0.55 -9.11 -0.49 2.15e-17 Mean corpuscular volume; CESC cis rs12142240 0.698 rs7515284 chr1:46809419 A/G cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs1577917 0.958 rs13219504 chr6:86556917 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.51 -6.48 -0.37 4.42e-10 Response to antipsychotic treatment; CESC cis rs763014 0.898 rs8050792 chr16:656033 T/C cg09263875 chr16:632152 PIGQ 0.67 11.42 0.57 7.69e-25 Height; CESC cis rs962856 0.619 rs7592026 chr2:67595139 A/G cg09028215 chr2:67624308 ETAA1 0.42 5.19 0.3 4.22e-7 Pancreatic cancer; CESC cis rs6429082 1.000 rs2055127 chr1:235598973 C/T cg26050004 chr1:235667680 B3GALNT2 -0.42 -5.46 -0.32 1.11e-7 Adiposity; CESC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg26354017 chr1:205819088 PM20D1 0.85 12.72 0.62 3e-29 Menarche (age at onset); CESC cis rs1003719 0.667 rs3753073 chr21:38466615 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.53 6.61 0.38 2.08e-10 Eye color traits; CESC cis rs8040855 0.547 rs17611171 chr15:85572699 T/A cg08123816 chr15:85640762 PDE8A -0.39 -5.85 -0.34 1.42e-8 Bulimia nervosa; CESC cis rs34779708 0.966 rs12775759 chr10:35400183 G/T cg03585969 chr10:35415529 CREM 0.77 10.1 0.53 1.71e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs17407555 0.647 rs55811736 chr4:10014221 G/A cg00071950 chr4:10020882 SLC2A9 -0.6 -6.13 -0.35 3.09e-9 Schizophrenia (age at onset); CESC cis rs72781680 0.898 rs72780111 chr2:23991146 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg22823121 chr1:150693482 HORMAD1 0.48 7.1 0.4 1.14e-11 Tonsillectomy; CESC cis rs2380220 0.808 rs2716069 chr6:95912976 C/G cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs9419702 0.568 rs7093241 chr10:133556596 G/A cg04492858 chr10:133558786 NA 0.44 6.54 0.37 3.2e-10 Survival in rectal cancer; CESC cis rs12136530 0.806 rs7522676 chr1:19762660 T/C cg01832549 chr1:19774989 CAPZB -0.47 -6.46 -0.37 4.86e-10 Lead levels in blood; CESC cis rs400736 0.526 rs10864329 chr1:8164460 G/A cg25007680 chr1:8021821 PARK7 -0.45 -5.89 -0.34 1.15e-8 Response to antidepressants and depression; CESC cis rs2070433 0.539 rs2070432 chr21:47957332 G/A cg12379764 chr21:47803548 PCNT 0.62 8.06 0.44 2.7e-14 Lymphocyte counts; CESC cis rs2742234 0.590 rs2565201 chr10:43618484 T/C cg07801480 chr10:43725741 RASGEF1A 0.4 5.26 0.31 3.04e-7 Hirschsprung disease; CESC cis rs2228479 0.850 rs62054224 chr16:89892071 C/T cg04013166 chr16:89971882 TCF25 0.67 5.49 0.32 9.55e-8 Skin colour saturation; CESC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs10979 1.000 rs9376760 chr6:143886969 C/T cg25407410 chr6:143891975 LOC285740 -0.59 -8.73 -0.47 2.93e-16 Hypospadias; CESC cis rs524023 0.957 rs561193 chr11:64353029 A/G cg07220939 chr11:64358617 SLC22A12 0.35 5.19 0.3 4.29e-7 Urate levels in obese individuals; CESC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs1348850 0.567 rs3770011 chr2:178537890 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 6.84 0.39 5.43e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11098499 0.955 rs56386062 chr4:120155135 T/C cg24375607 chr4:120327624 NA 0.42 5.05 0.3 8.26e-7 Corneal astigmatism; CESC cis rs6429082 0.755 rs291370 chr1:235693041 A/G cg26050004 chr1:235667680 B3GALNT2 0.65 8.6 0.47 7.22e-16 Adiposity; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04090027 chr2:97760622 FAHD2B 0.46 6.38 0.36 8.05e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7424096 0.582 rs12105781 chr2:37221567 T/C cg14987922 chr2:37194071 STRN 0.5 5.46 0.32 1.1e-7 High light scatter reticulocyte percentage of red cells; CESC cis rs7937682 0.889 rs1789361 chr11:111485334 T/C cg22437258 chr11:111473054 SIK2 0.71 9.56 0.51 8.68e-19 Primary sclerosing cholangitis; CESC cis rs1707322 0.752 rs11211173 chr1:46219376 C/T cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6120849 0.754 rs6119560 chr20:33606977 G/C cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg18301423 chr5:131593218 PDLIM4 0.38 5.46 0.32 1.12e-7 Breast cancer; CESC cis rs3796352 1.000 rs13078971 chr3:53103645 G/C cg12962167 chr3:53033115 SFMBT1 0.71 6.22 0.36 1.92e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs12681366 0.564 rs10808669 chr8:95481061 A/C cg13257157 chr8:95487014 RAD54B 0.45 5.44 0.32 1.22e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg24733560 chr20:60626293 TAF4 0.42 5.7 0.33 3.17e-8 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00504756 chr16:74330795 PSMD7 0.58 6.63 0.38 1.88e-10 Gut microbiome composition (summer); CESC trans rs4498364 0.541 rs760829 chr6:97550414 G/A cg09636063 chr6:158957850 TMEM181 0.44 6.31 0.36 1.2e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs123509 0.913 rs339682 chr3:42791123 A/G cg12982090 chr3:42733453 KBTBD5 0.74 8.94 0.48 6.82e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg18876405 chr7:65276391 NA -0.51 -5.96 -0.34 8.21e-9 Aortic root size; CESC cis rs5167 0.566 rs204905 chr19:45460764 G/A cg09555818 chr19:45449301 APOC2 0.47 7.22 0.41 5.6e-12 Blood protein levels; CESC cis rs317689 0.581 rs315132 chr12:69761996 G/C cg14784868 chr12:69753453 YEATS4 0.72 9.53 0.51 1.06e-18 Response to diuretic therapy; CESC cis rs11638352 1.000 rs890465 chr15:44356463 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.62 6.0 0.35 6.51e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg26408565 chr15:76604113 ETFA -0.41 -5.99 -0.35 6.8e-9 Blood metabolite levels; CESC cis rs67460515 0.563 rs35914913 chr3:160826561 A/G cg03342759 chr3:160939853 NMD3 -0.51 -6.55 -0.37 3.06e-10 Parkinson's disease; CESC cis rs6952809 0.532 rs6953297 chr7:2440874 C/G cg23289794 chr7:2394357 EIF3B -0.71 -6.72 -0.38 1.09e-10 Multiple sclerosis; CESC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg00684032 chr4:1343700 KIAA1530 0.35 5.45 0.32 1.15e-7 Obesity-related traits; CESC cis rs7771547 0.573 rs10440841 chr6:36399086 G/A cg04289385 chr6:36355825 ETV7 -0.38 -5.57 -0.32 6.41e-8 Platelet distribution width; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24963443 chr5:180673122 NA -0.44 -7.02 -0.4 1.9e-11 Gambling; CESC cis rs7520050 0.966 rs6701614 chr1:46309420 G/C cg24296786 chr1:45957014 TESK2 0.42 5.39 0.31 1.6e-7 Red blood cell count;Reticulocyte count; CESC cis rs4481887 1.000 rs6663817 chr1:248495613 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.57 0.37 2.64e-10 Common traits (Other); CESC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg04775059 chr7:64541387 NA 0.44 5.31 0.31 2.38e-7 Calcium levels; CESC cis rs6964587 1.000 rs6974607 chr7:91750116 G/A cg17063962 chr7:91808500 NA 0.53 7.14 0.4 9.24e-12 Breast cancer; CESC cis rs67460515 0.892 rs11711695 chr3:161057593 A/G cg03342759 chr3:160939853 NMD3 -0.54 -8.13 -0.45 1.68e-14 Parkinson's disease; CESC cis rs12118280 0.581 rs545593 chr1:108720242 G/A cg11967332 chr1:108735228 SLC25A24 -0.6 -6.71 -0.38 1.15e-10 Myeloid white cell count; CESC cis rs709400 0.663 rs9671911 chr14:103967343 T/C cg12935359 chr14:103987150 CKB -0.52 -7.51 -0.42 8.84e-13 Body mass index; CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg16145915 chr7:1198662 ZFAND2A -0.81 -14.46 -0.66 2.47e-35 Longevity;Endometriosis; CESC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.85 0.62 1.08e-29 Gut microbiome composition (summer); CESC cis rs7937682 0.889 rs1784785 chr11:111483306 A/G cg09085632 chr11:111637200 PPP2R1B -0.95 -14.72 -0.67 3.09e-36 Primary sclerosing cholangitis; CESC cis rs9916302 0.904 rs6503503 chr17:37514373 G/A cg20243544 chr17:37824526 PNMT -0.47 -5.74 -0.33 2.54e-8 Glomerular filtration rate (creatinine); CESC cis rs1550582 1.000 rs16905157 chr8:135519964 C/T cg17885191 chr8:135476712 NA 0.64 7.41 0.41 1.74e-12 Educational attainment; CESC cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC trans rs2975734 0.709 rs6988826 chr8:10109625 T/C cg15556689 chr8:8085844 FLJ10661 -0.54 -6.11 -0.35 3.47e-9 Morning vs. evening chronotype;Chronotype; CESC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs6912958 0.781 rs2273129 chr6:88182439 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -5.83 -0.34 1.58e-8 Monocyte percentage of white cells; CESC cis rs10242455 0.702 rs78080383 chr7:99064465 C/T cg25640893 chr7:99214727 ZNF498 1.16 7.09 0.4 1.22e-11 Blood metabolite levels; CESC cis rs1153858 1.000 rs2066090 chr15:45650018 T/C cg21132104 chr15:45694354 SPATA5L1 0.84 11.41 0.57 8.8e-25 Homoarginine levels; CESC trans rs2727020 0.576 rs10839305 chr11:49598733 T/C cg03929089 chr4:120376271 NA -0.86 -13.52 -0.64 4.87e-32 Coronary artery disease; CESC cis rs7680126 0.672 rs4697957 chr4:10182254 A/G cg11266682 chr4:10021025 SLC2A9 -0.41 -5.2 -0.3 3.94e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg10691866 chr7:65817282 TPST1 -0.35 -5.6 -0.33 5.33e-8 Aortic root size; CESC cis rs67311347 1.000 rs9822909 chr3:40457084 G/T cg09455208 chr3:40491958 NA 0.47 7.07 0.4 1.38e-11 Renal cell carcinoma; CESC cis rs4555082 0.874 rs4677 chr14:105717279 T/C cg10792982 chr14:105748885 BRF1 0.42 5.57 0.32 6.39e-8 Mean platelet volume;Platelet distribution width; CESC cis rs10751667 0.643 rs7394436 chr11:970373 G/C cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.49e-7 Alzheimer's disease (late onset); CESC cis rs561341 1.000 rs693116 chr17:30246124 C/T cg12193833 chr17:30244370 NA -0.76 -6.85 -0.39 5.14e-11 Hip circumference adjusted for BMI; CESC cis rs17253792 0.545 rs34719936 chr14:56015134 G/A cg01858014 chr14:56050164 KTN1 -0.81 -5.71 -0.33 3.08e-8 Putamen volume; CESC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg01579765 chr21:45077557 HSF2BP -0.52 -9.17 -0.49 1.39e-17 Mean corpuscular volume; CESC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg04944784 chr2:26401820 FAM59B -0.91 -10.4 -0.54 1.82e-21 Gut microbiome composition (summer); CESC cis rs3096299 0.933 rs3114848 chr16:89452771 G/A cg00750074 chr16:89608354 SPG7 -0.37 -5.24 -0.31 3.3e-7 Multiple myeloma (IgH translocation); CESC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg11987759 chr7:65425863 GUSB -0.47 -6.49 -0.37 4.32e-10 Aortic root size; CESC cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg23018236 chr17:30244563 NA -0.52 -5.1 -0.3 6.39e-7 Hip circumference adjusted for BMI; CESC cis rs6835098 0.962 rs4419455 chr4:174083622 C/T cg08422745 chr4:174089978 GALNT7 0.75 9.77 0.51 1.83e-19 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs10751667 1.000 rs10751667 chr11:941941 A/T cg06064525 chr11:970664 AP2A2 -0.42 -7.62 -0.42 4.56e-13 Alzheimer's disease (late onset); CESC cis rs9815354 1.000 rs1716993 chr3:41974556 G/C cg03022575 chr3:42003672 ULK4 -0.46 -5.34 -0.31 1.99e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs4654899 0.758 rs12078457 chr1:21397071 C/T cg05370193 chr1:21551575 ECE1 0.36 5.41 0.32 1.39e-7 Superior frontal gyrus grey matter volume; CESC cis rs2997447 0.761 rs61776576 chr1:26429898 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.6 5.14 0.3 5.43e-7 QRS complex (12-leadsum); CESC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg19592336 chr6:28129416 ZNF389 0.44 6.39 0.37 7.51e-10 Parkinson's disease; CESC cis rs2730245 0.593 rs842699 chr7:158663404 T/A cg01943577 chr7:158741284 NA -0.46 -6.07 -0.35 4.5e-9 Height; CESC cis rs17376456 0.825 rs56108532 chr5:93276342 C/T cg25358565 chr5:93447407 FAM172A 1.11 10.56 0.54 5.4e-22 Diabetic retinopathy; CESC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg27170947 chr2:26402098 FAM59B -0.84 -9.99 -0.52 3.83e-20 Gut microbiome composition (summer); CESC cis rs2304069 0.733 rs216138 chr5:149437190 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.77 9.35 0.5 3.95e-18 HIV-1 control; CESC cis rs11098499 0.754 rs7672594 chr4:120248543 A/C cg09307838 chr4:120376055 NA 0.78 10.55 0.54 5.92e-22 Corneal astigmatism; CESC cis rs7044106 0.762 rs10984972 chr9:123409864 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.84 13.77 0.65 6.71e-33 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21161649 chr21:45284362 AGPAT3 0.58 6.34 0.36 9.61e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21789044 chr6:5085404 PPP1R3G -0.47 -6.49 -0.37 4.25e-10 Fibrinogen levels; CESC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg05313129 chr8:58192883 C8orf71 -0.48 -5.14 -0.3 5.46e-7 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2425143 1.000 rs6060557 chr20:34270266 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.16 0.3 4.75e-7 Blood protein levels; CESC cis rs763121 0.853 rs1569716 chr22:38998519 C/A cg21395723 chr22:39101663 GTPBP1 0.48 6.39 0.37 7.43e-10 Menopause (age at onset); CESC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.36 0.31 1.8e-7 Bipolar disorder; CESC cis rs9611565 0.729 rs132902 chr22:41797758 A/G cg17376030 chr22:41985996 PMM1 0.55 6.07 0.35 4.32e-9 Vitiligo; CESC cis rs1878931 0.580 rs7204571 chr16:3402444 T/C cg22508957 chr16:3507546 NAT15 -0.36 -5.08 -0.3 7.05e-7 Body mass index (adult); CESC cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1707322 0.717 rs1135850 chr1:46093692 G/A cg05343316 chr1:45956843 TESK2 0.52 6.53 0.37 3.41e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9341808 0.558 rs2490234 chr6:80816966 G/C cg08355045 chr6:80787529 NA 0.34 5.19 0.3 4.13e-7 Sitting height ratio; CESC cis rs9300255 0.568 rs1790090 chr12:123633424 G/A cg19016782 chr12:123741754 C12orf65 -0.37 -5.04 -0.3 8.55e-7 Neutrophil percentage of white cells; CESC cis rs9303280 0.806 rs36095411 chr17:38031865 T/G cg19468946 chr17:37922297 IKZF3 -0.42 -5.57 -0.32 6.19e-8 Self-reported allergy; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg17174230 chr11:65337779 SSSCA1 -0.47 -6.11 -0.35 3.57e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg09323728 chr8:95962352 TP53INP1 -0.38 -8.2 -0.45 1.06e-14 Type 2 diabetes; CESC cis rs11676348 0.818 rs1126579 chr2:219000734 T/C cg00012203 chr2:219082015 ARPC2 -0.58 -7.62 -0.42 4.43e-13 Ulcerative colitis; CESC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.5 -0.54 8.34e-22 Alzheimer's disease; CESC trans rs2727020 0.636 rs10839275 chr11:49438962 T/A cg15704280 chr7:45808275 SEPT13 -0.9 -15.53 -0.69 3.95e-39 Coronary artery disease; CESC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg04414720 chr1:150670196 GOLPH3L 0.44 5.83 0.34 1.6e-8 Melanoma; CESC cis rs614226 0.872 rs12307148 chr12:120903179 T/C cg01236616 chr12:121019343 POP5 -1.39 -15.84 -0.7 3.24e-40 Type 1 diabetes nephropathy; CESC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg27266027 chr21:40555129 PSMG1 0.49 6.01 0.35 6.14e-9 Cognitive function; CESC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg12463550 chr7:65579703 CRCP -0.53 -6.77 -0.38 8.05e-11 Aortic root size; CESC cis rs911555 0.755 rs55742283 chr14:103942965 A/G cg24130564 chr14:104152367 KLC1 0.48 6.21 0.36 2.09e-9 Intelligence (multi-trait analysis); CESC cis rs2204008 0.641 rs2387810 chr12:38368875 G/T cg26384229 chr12:38710491 ALG10B 0.73 10.96 0.56 2.65e-23 Bladder cancer; CESC cis rs67311347 1.000 rs9875245 chr3:40442280 G/T cg09455208 chr3:40491958 NA 0.5 8.28 0.45 6.1e-15 Renal cell carcinoma; CESC cis rs9611565 0.879 rs2235845 chr22:41729294 T/G cg03806693 chr22:41940476 POLR3H -0.71 -8.51 -0.46 1.32e-15 Vitiligo; CESC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg02038168 chr22:39784481 NA -0.66 -8.29 -0.45 5.63e-15 Intelligence (multi-trait analysis); CESC cis rs7264396 0.790 rs11697903 chr20:34272224 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 2.93e-26 Total cholesterol levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24182333 chr10:73610570 PSAP 0.45 6.33 0.36 1.04e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13095912 0.889 rs35917986 chr3:185310041 G/A cg11274856 chr3:185301563 NA 0.37 6.05 0.35 5.02e-9 Systolic blood pressure; CESC cis rs7927592 0.956 rs10896343 chr11:68317860 G/C cg16797656 chr11:68205561 LRP5 0.4 5.51 0.32 8.62e-8 Total body bone mineral density; CESC cis rs7772486 0.837 rs2474354 chr6:146323795 T/A cg05347473 chr6:146136440 FBXO30 0.48 6.51 0.37 3.83e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs8062405 1.000 rs62036626 chr16:28844284 A/G cg08761264 chr16:28874980 SH2B1 -0.46 -5.72 -0.33 2.9e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs738322 0.967 rs2092180 chr22:38571563 A/G cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg13880726 chr7:1868755 MAD1L1 -0.51 -5.35 -0.31 1.9e-7 Bipolar disorder; CESC cis rs7666738 0.830 rs10014284 chr4:98681951 G/C cg17366294 chr4:99064904 C4orf37 0.56 7.61 0.42 4.87e-13 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.622 rs11637296 chr15:77207885 C/A cg23625390 chr15:77176239 SCAPER -0.39 -5.18 -0.3 4.39e-7 Blood metabolite levels; CESC cis rs735396 0.595 rs2258287 chr12:121454313 G/T cg15155738 chr12:121454335 C12orf43 0.43 5.1 0.3 6.55e-7 N-glycan levels; CESC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg06877462 chr1:205807181 PM20D1 0.37 5.38 0.31 1.64e-7 Menarche (age at onset); CESC cis rs7666738 0.822 rs9992360 chr4:98937123 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7225537 0.559 rs3744137 chr17:17046024 C/A cg20098446 chr17:17120238 FLCN 0.33 5.13 0.3 5.68e-7 Mean platelet volume; CESC cis rs10411936 0.750 rs8112401 chr19:16593012 C/T cg10248733 chr19:16607483 C19orf44;CALR3 0.53 6.59 0.38 2.36e-10 White blood cell count;Multiple sclerosis; CESC cis rs7264396 0.635 rs6060685 chr20:34512023 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.07 -0.56 1.13e-23 Total cholesterol levels; CESC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg16325326 chr1:53192061 ZYG11B 0.82 13.08 0.63 1.64e-30 Monocyte count; CESC cis rs8040855 0.576 rs62022527 chr15:85531253 A/G cg08123816 chr15:85640762 PDE8A -0.39 -5.69 -0.33 3.36e-8 Bulimia nervosa; CESC cis rs2276314 1.000 rs9956938 chr18:33567061 A/G cg05985134 chr18:33552581 C18orf21 0.62 6.94 0.39 2.94e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs9303401 0.659 rs2072316 chr17:56604813 G/T cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.92 0.62 6.16e-30 Cognitive test performance; CESC cis rs2115630 0.645 rs3825878 chr15:85174755 C/T cg12501888 chr15:85177176 SCAND2 -0.48 -6.34 -0.36 9.89e-10 P wave terminal force; CESC cis rs6570726 0.935 rs432086 chr6:145841593 C/T cg23711669 chr6:146136114 FBXO30 -0.79 -11.63 -0.58 1.56e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs9902453 0.967 rs34323226 chr17:28517454 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.85 0.43 1.01e-13 Coffee consumption (cups per day); CESC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg12412775 chr1:25698385 RHCE -0.32 -5.8 -0.34 1.84e-8 Erythrocyte sedimentation rate; CESC cis rs9911578 0.967 rs11079354 chr17:56594460 G/A cg12560992 chr17:57184187 TRIM37 -0.93 -15.59 -0.69 2.43e-39 Intelligence (multi-trait analysis); CESC cis rs8114671 0.552 rs2024635 chr20:33422614 G/A cg07148914 chr20:33460835 GGT7 0.42 5.38 0.31 1.63e-7 Height; CESC cis rs1552244 0.748 rs9862221 chr3:10059658 G/T cg16606324 chr3:10149918 C3orf24 0.44 5.24 0.31 3.21e-7 Alzheimer's disease; CESC cis rs4253772 0.550 rs6007761 chr22:46670394 C/T cg24881330 chr22:46731750 TRMU -0.78 -8.73 -0.47 2.9e-16 LDL cholesterol;Cholesterol, total; CESC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg02038168 chr22:39784481 NA -0.62 -7.66 -0.43 3.51e-13 Intelligence (multi-trait analysis); CESC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg00784671 chr22:46762841 CELSR1 -0.51 -5.48 -0.32 9.94e-8 LDL cholesterol;Cholesterol, total; CESC cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg12386194 chr3:101231763 SENP7 0.57 6.55 0.37 3e-10 Colonoscopy-negative controls vs population controls; CESC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg20887711 chr4:1340912 KIAA1530 0.53 7.46 0.42 1.23e-12 Longevity; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10978402 chr15:90931990 IQGAP1 -0.52 -6.38 -0.36 8.03e-10 Ulcerative colitis; CESC cis rs7520050 0.966 rs1707304 chr1:46598269 C/A cg03146154 chr1:46216737 IPP -0.42 -5.35 -0.31 1.88e-7 Red blood cell count;Reticulocyte count; CESC cis rs6062302 0.534 rs1556456 chr20:62216289 T/C cg06363034 chr20:62225388 GMEB2 -0.52 -6.58 -0.37 2.53e-10 Glioblastoma; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11586605 chr11:108535779 DDX10 -0.46 -6.15 -0.35 2.79e-9 Ulcerative colitis; CESC cis rs863345 0.604 rs2157687 chr1:158493000 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.86 -0.39 4.84e-11 Pneumococcal bacteremia; CESC cis rs9811920 0.965 rs10222474 chr3:99862551 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.45 5.83 0.34 1.62e-8 Axial length; CESC cis rs5753618 0.504 rs5753659 chr22:31893613 A/G cg13145458 chr22:31556086 RNF185 -0.5 -5.42 -0.32 1.37e-7 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03342113 chr11:61197477 CPSF7;SDHAF2 0.63 7.63 0.42 4.19e-13 Gut microbiome composition (summer); CESC cis rs12586317 0.547 rs3759548 chr14:35450333 C/T cg05294307 chr14:35346193 BAZ1A -0.51 -5.44 -0.32 1.23e-7 Psoriasis; CESC cis rs4803455 0.586 rs4803457 chr19:41861359 T/C cg09537434 chr19:41945824 ATP5SL -0.71 -9.68 -0.51 3.49e-19 Migraine;Coronary artery disease; CESC cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.42 5.1 0.3 6.53e-7 Eosinophil percentage of white cells; CESC cis rs13082711 0.871 rs13061912 chr3:27495586 A/G cg02860705 chr3:27208620 NA 0.51 6.33 0.36 1.06e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs3106136 0.527 rs4693376 chr4:95157240 A/G cg11021082 chr4:95130006 SMARCAD1 -0.63 -9.7 -0.51 3.19e-19 Capecitabine sensitivity; CESC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg04267008 chr7:1944627 MAD1L1 -0.71 -9.11 -0.49 2.06e-17 Bipolar disorder and schizophrenia; CESC cis rs17854409 0.881 rs6011430 chr20:61497014 C/T cg05147244 chr20:61493195 TCFL5 -0.85 -6.82 -0.39 6.03e-11 Obesity-related traits; CESC cis rs7084402 0.967 rs1649037 chr10:60331135 C/T cg07615347 chr10:60278583 BICC1 0.6 9.27 0.5 6.55e-18 Refractive error; CESC cis rs2839186 0.934 rs13049797 chr21:47707582 T/C cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 7.02e-11 Testicular germ cell tumor; CESC cis rs763121 0.853 rs2413545 chr22:39092524 C/T cg06022373 chr22:39101656 GTPBP1 0.85 12.34 0.6 6.24e-28 Menopause (age at onset); CESC cis rs7809950 1.000 rs2520260 chr7:107172794 A/G cg23024343 chr7:107201750 COG5 -0.41 -5.71 -0.33 3.03e-8 Coronary artery disease; CESC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg12463550 chr7:65579703 CRCP -0.55 -7.02 -0.4 1.82e-11 Aortic root size; CESC cis rs10465746 0.780 rs6703493 chr1:84435812 G/A cg10977910 chr1:84465055 TTLL7 0.53 7.33 0.41 2.77e-12 Obesity-related traits; CESC cis rs11864453 0.713 rs2241412 chr16:72144284 A/G cg16558253 chr16:72132732 DHX38 -0.55 -8.77 -0.47 2.24e-16 Fibrinogen levels; CESC cis rs7914558 0.966 rs3758543 chr10:104944744 C/G cg04362960 chr10:104952993 NT5C2 0.46 6.16 0.35 2.74e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.51 -5.7 -0.33 3.21e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs78456975 1.000 rs111935361 chr2:1554192 C/A cg01028140 chr2:1542097 TPO -0.58 -5.9 -0.34 1.1e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs2425143 1.000 rs1056196 chr20:34327159 T/A cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.3 0.31 2.46e-7 Blood protein levels; CESC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.21 -0.36 2.01e-9 Schizophrenia; CESC cis rs2228479 0.850 rs62056065 chr16:89905115 C/G cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs9611565 0.569 rs6002328 chr22:41710034 T/C cg03806693 chr22:41940476 POLR3H -0.7 -8.29 -0.45 5.91e-15 Vitiligo; CESC trans rs9929218 0.551 rs8051095 chr16:68722049 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.98 17.14 0.73 8.09e-45 Colorectal cancer; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg22068822 chr5:171682568 UBTD2 -0.43 -6.3 -0.36 1.25e-9 Vertical cup-disc ratio; CESC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.79 -0.39 7.19e-11 Developmental language disorder (linguistic errors); CESC cis rs2295359 0.892 rs17375018 chr1:67655147 A/G cg03340356 chr1:67600835 NA -0.31 -5.25 -0.31 3.06e-7 Psoriasis; CESC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.78 0.33 2.15e-8 Personality dimensions; CESC cis rs7223966 0.921 rs2854207 chr17:61947107 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.46 0.37 5.06e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7520050 0.966 rs6680380 chr1:46300189 T/G cg03146154 chr1:46216737 IPP -0.47 -6.15 -0.35 2.87e-9 Red blood cell count;Reticulocyte count; CESC trans rs35110281 0.712 rs162345 chr21:44954155 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.69 0.38 1.35e-10 Mean corpuscular volume; CESC cis rs9796 0.804 rs28688742 chr15:41403638 G/A cg18705301 chr15:41695430 NDUFAF1 -0.47 -6.94 -0.39 3.09e-11 Menopause (age at onset); CESC cis rs8070624 0.543 rs8068175 chr17:17874486 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.13 0.45 1.68e-14 Total body bone mineral density; CESC cis rs9287719 0.967 rs6432116 chr2:10748615 T/C cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg23074011 chr10:75545361 KIAA0913 0.43 6.13 0.35 3.17e-9 Systemic lupus erythematosus; CESC cis rs7786808 0.741 rs4909222 chr7:158228095 C/T cg09998033 chr7:158218633 PTPRN2 0.43 6.41 0.37 6.54e-10 Obesity-related traits; CESC cis rs10492096 1.000 rs11064218 chr12:6586261 C/T cg13857086 chr12:6580257 VAMP1 0.65 6.17 0.35 2.59e-9 Hip geometry; CESC cis rs892961 0.899 rs8071024 chr17:75414067 T/C cg05865280 chr17:75406074 SEPT9 0.63 12.76 0.62 2.1e-29 Airflow obstruction; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02685901 chr6:43597772 MAD2L1BP;GTPBP2 -0.43 -6.22 -0.36 1.89e-9 Gambling; CESC cis rs72945132 0.882 rs11235967 chr11:70191691 T/C cg14191688 chr11:70257035 CTTN 0.43 5.5 0.32 8.9e-8 Coronary artery disease; CESC cis rs4604732 0.631 rs74154675 chr1:247625836 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg22535103 chr8:58192502 C8orf71 -0.92 -9.07 -0.49 2.85e-17 Developmental language disorder (linguistic errors); CESC cis rs3815700 1.000 rs7260624 chr19:33096562 A/G cg02997394 chr19:33096574 ANKRD27 0.71 7.32 0.41 2.93e-12 Eosinophilic esophagitis; CESC cis rs1153858 0.723 rs4580098 chr15:45596909 T/A cg21132104 chr15:45694354 SPATA5L1 0.8 10.19 0.53 8.67e-21 Homoarginine levels; CESC cis rs1538970 0.924 rs10890327 chr1:45891458 C/T cg24296786 chr1:45957014 TESK2 -0.46 -5.3 -0.31 2.41e-7 Platelet count; CESC cis rs6963495 0.769 rs117986187 chr7:105167311 G/A cg02135003 chr7:105160482 PUS7 -0.46 -5.51 -0.32 8.38e-8 Bipolar disorder (body mass index interaction); CESC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg26314531 chr2:26401878 FAM59B -0.61 -6.87 -0.39 4.62e-11 Gut microbiome composition (summer); CESC cis rs3749237 0.595 rs11130196 chr3:49490149 A/C cg03060546 chr3:49711283 APEH 0.77 11.69 0.58 9.65e-26 Resting heart rate; CESC cis rs9911578 1.000 rs12602346 chr17:56901713 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 3.04e-7 Intelligence (multi-trait analysis); CESC cis rs12136530 0.577 rs12120180 chr1:19791441 C/T cg01832549 chr1:19774989 CAPZB -0.39 -5.45 -0.32 1.15e-7 Lead levels in blood; CESC cis rs2732480 0.500 rs2450991 chr12:48651621 A/G cg04545296 chr12:48745243 ZNF641 0.39 6.62 0.38 1.99e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs1577917 0.958 rs12192546 chr6:86476484 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.49 6.18 0.35 2.45e-9 Response to antipsychotic treatment; CESC cis rs7927592 0.913 rs7115374 chr11:68300076 G/T cg20283391 chr11:68216788 NA -0.62 -7.44 -0.42 1.42e-12 Total body bone mineral density; CESC cis rs4820803 1.000 rs4820803 chr22:29669648 C/G cg07256473 chr22:29710276 RASL10A -0.43 -5.15 -0.3 5.1e-7 Breast cancer; CESC cis rs8114671 0.967 rs2069945 chr20:33761837 C/G cg24642439 chr20:33292090 TP53INP2 0.45 5.61 0.33 5.1e-8 Height; CESC cis rs7605827 0.930 rs10179754 chr2:15541214 C/T cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs7264396 0.563 rs2425132 chr20:34338390 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.59 6.62 0.38 2.03e-10 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05062148 chr1:25757186 TMEM57 -0.55 -6.09 -0.35 3.91e-9 Gut microbiome composition (summer); CESC cis rs4242434 0.672 rs4615566 chr8:22520682 T/C cg03733263 chr8:22462867 KIAA1967 -0.74 -11.16 -0.57 5.77e-24 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs2243480 1.000 rs313809 chr7:65499983 G/A cg12463550 chr7:65579703 CRCP 0.69 5.5 0.32 9.17e-8 Diabetic kidney disease; CESC cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg02592271 chr2:27665507 KRTCAP3 -0.33 -6.5 -0.37 3.97e-10 Total body bone mineral density; CESC cis rs9818758 0.607 rs34326553 chr3:49134429 A/G cg00383909 chr3:49044727 WDR6 0.91 6.46 0.37 5.08e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg07507251 chr3:52567010 NT5DC2 -0.37 -6.29 -0.36 1.33e-9 Bipolar disorder; CESC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg17650747 chr5:1873721 NA 0.43 5.93 0.34 9.42e-9 Cardiovascular disease risk factors; CESC cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.64 7.46 0.42 1.27e-12 Age-related macular degeneration (geographic atrophy); CESC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg00409905 chr10:38381863 ZNF37A -0.5 -6.71 -0.38 1.15e-10 Extrinsic epigenetic age acceleration; CESC cis rs6696846 0.691 rs11240370 chr1:205118336 T/G cg00857998 chr1:205179979 DSTYK 0.57 7.45 0.42 1.28e-12 Red blood cell count; CESC cis rs9304742 0.962 rs12461778 chr19:53454963 T/A cg09915433 chr19:53449742 NA -0.37 -5.04 -0.3 8.59e-7 Psoriasis; CESC cis rs2204008 0.605 rs4608149 chr12:38132057 G/C cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22541143 chr4:84377292 HELQ;MRPS18C -0.47 -6.21 -0.36 2.02e-9 Ulcerative colitis; CESC cis rs4974559 0.790 rs5019560 chr4:1324793 G/A cg02980000 chr4:1222292 CTBP1 0.68 7.68 0.43 3.07e-13 Systolic blood pressure; CESC cis rs1580019 0.537 rs7804609 chr7:32558094 A/C cg07520158 chr7:32535189 LSM5;AVL9 0.53 6.74 0.38 1.01e-10 Cognitive ability; CESC cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.94e-9 Extrinsic epigenetic age acceleration; CESC cis rs10911232 0.524 rs4652773 chr1:183054827 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 13.44 0.64 9.64e-32 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12753895 chr1:46216422 IPP 0.64 7.05 0.4 1.59e-11 Gut microbiome composition (summer); CESC cis rs7799006 0.606 rs34262822 chr7:2304275 C/T cg08027265 chr7:2291960 NA -0.57 -9.64 -0.51 4.77e-19 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.29e-7 Life satisfaction; CESC cis rs34638657 0.732 rs2911425 chr16:82203026 T/C cg09439754 chr16:82129088 HSD17B2 -0.37 -6.4 -0.37 7.17e-10 Lung adenocarcinoma; CESC cis rs35146811 1.000 rs35146811 chr7:99720994 A/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.45 5.52 0.32 8.15e-8 Coronary artery disease; CESC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg01988459 chr11:68622903 NA -0.39 -5.4 -0.31 1.49e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4481887 0.741 rs28444488 chr1:248531776 C/A cg26353448 chr1:248524236 OR2T4 -0.38 -5.31 -0.31 2.3e-7 Common traits (Other); CESC trans rs801193 1.000 rs3778909 chr7:66255646 G/C cg26939375 chr7:64535504 NA 0.66 9.12 0.49 1.89e-17 Aortic root size; CESC cis rs67311347 1.000 rs56303661 chr3:40520778 C/G cg09455208 chr3:40491958 NA 0.51 8.42 0.46 2.37e-15 Renal cell carcinoma; CESC cis rs8028182 0.636 rs12909863 chr15:75825822 G/C cg20655648 chr15:75932815 IMP3 0.48 6.02 0.35 5.64e-9 Sudden cardiac arrest; CESC cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs116095464 0.558 rs9312979 chr5:222057 A/C cg16372103 chr5:203701 NA 0.49 5.29 0.31 2.58e-7 Breast cancer; CESC cis rs4604732 0.578 rs112449432 chr1:247624180 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.34 0.36 1e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs3857536 0.813 rs6455084 chr6:66935658 A/T cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC trans rs17685 0.784 rs1613890 chr7:75735037 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.47 0.61 2.13e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg00149659 chr3:10157352 C3orf10 0.74 8.79 0.48 1.96e-16 Alzheimer's disease; CESC cis rs1881797 1.000 rs68059491 chr1:247683070 C/T cg11166453 chr1:247681781 NA 0.45 5.65 0.33 4.03e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs56399783 0.901 rs73033407 chr7:2878857 G/C cg19731401 chr7:2775893 GNA12 0.62 5.3 0.31 2.38e-7 Childhood ear infection; CESC cis rs2267137 0.903 rs2072051 chr22:29755888 C/T cg07256473 chr22:29710276 RASL10A -0.41 -6.17 -0.35 2.54e-9 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs6424115 0.793 rs2502998 chr1:24198327 T/A cg10978503 chr1:24200527 CNR2 0.34 6.72 0.38 1.11e-10 Immature fraction of reticulocytes; CESC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.24e-30 Prudent dietary pattern; CESC cis rs7937682 0.632 rs1045282 chr11:111754574 A/C cg09085632 chr11:111637200 PPP2R1B 0.87 10.93 0.56 3.49e-23 Primary sclerosing cholangitis; CESC cis rs73206853 0.764 rs7966591 chr12:110644045 G/A cg12870014 chr12:110450643 ANKRD13A 0.69 5.97 0.34 7.55e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7551222 0.681 rs2045623 chr1:204497413 A/G cg20240347 chr1:204465584 NA -0.28 -5.59 -0.32 5.78e-8 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00280548 chr10:70587131 STOX1 0.62 7.14 0.4 8.76e-12 Gut microbiome composition (summer); CESC cis rs6714710 0.603 rs2305143 chr2:98413781 C/T cg26665480 chr2:98280029 ACTR1B 0.56 7.92 0.44 6.75e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs11166927 0.934 rs7015426 chr8:140802688 C/G cg16909799 chr8:140841666 TRAPPC9 0.57 8.46 0.46 1.85e-15 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs175714 0.845 rs175702 chr14:75971133 G/T cg01624173 chr14:75981868 NA -0.55 -7.96 -0.44 4.91e-14 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20631654 chr20:56285704 PMEPA1 -0.6 -6.82 -0.39 6.25e-11 Gut microbiome composition (summer); CESC cis rs4835473 0.932 rs4835279 chr4:144710070 G/C cg25736465 chr4:144833511 NA -0.33 -5.43 -0.32 1.28e-7 Immature fraction of reticulocytes; CESC cis rs67460515 0.926 rs13062740 chr3:161024208 G/A cg03342759 chr3:160939853 NMD3 -0.52 -7.26 -0.41 4.28e-12 Parkinson's disease; CESC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg03709012 chr19:19516395 GATAD2A -0.94 -13.72 -0.64 1.01e-32 Tonsillectomy; CESC cis rs933688 0.818 rs10052492 chr5:90759930 T/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.0 12.68 0.61 3.98e-29 Smoking behavior; CESC cis rs1153858 1.000 rs3759899 chr15:45655903 T/C cg21132104 chr15:45694354 SPATA5L1 0.86 11.64 0.58 1.46e-25 Homoarginine levels; CESC cis rs7714584 0.793 rs11949375 chr5:150202980 T/C cg22134413 chr5:150180641 NA 0.5 5.33 0.31 2.15e-7 Crohn's disease; CESC cis rs7666738 0.546 rs13141117 chr4:98892798 G/A cg17366294 chr4:99064904 C4orf37 0.48 5.93 0.34 9.25e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg26119090 chr2:26468346 HADHA;HADHB 0.63 7.55 0.42 6.93e-13 Gut microbiome composition (summer); CESC cis rs6942756 1.000 rs11979476 chr7:128993756 G/T cg02491457 chr7:128862824 NA 0.65 8.63 0.47 5.89e-16 White matter hyperintensity burden; CESC cis rs8016982 0.611 rs8008870 chr14:81709374 C/T cg01989461 chr14:81687754 GTF2A1 0.71 10.82 0.55 7.97e-23 Schizophrenia; CESC cis rs5753618 0.583 rs5753615 chr22:31828027 T/C cg02404636 chr22:31891804 SFI1 0.4 5.4 0.31 1.49e-7 Colorectal cancer; CESC cis rs11690935 0.959 rs10206062 chr2:172577276 A/T cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.72 -0.67 2.89e-36 Schizophrenia; CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg24642844 chr7:1081250 C7orf50 -0.39 -5.12 -0.3 5.99e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09000510 chr9:35605352 TESK1 0.64 7.44 0.42 1.37e-12 Gut microbiome composition (summer); CESC cis rs78456975 0.622 rs11896517 chr2:1518112 A/G cg01028140 chr2:1542097 TPO -0.47 -5.39 -0.31 1.55e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg19052272 chr2:3704530 ALLC 0.54 6.84 0.39 5.34e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs3820068 0.603 rs7531396 chr1:15969870 G/C cg13390004 chr1:15929781 NA 0.37 5.84 0.34 1.51e-8 Systolic blood pressure; CESC cis rs11051970 0.592 rs12227991 chr12:32540045 C/G cg24626660 chr12:32551988 NA 0.38 5.12 0.3 5.82e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs11098499 0.691 rs12510133 chr4:120271344 A/C cg09307838 chr4:120376055 NA 0.77 10.19 0.53 8.72e-21 Corneal astigmatism; CESC cis rs501120 0.657 rs617542 chr10:44743636 G/A cg09554077 chr10:44749378 NA 0.43 5.19 0.3 4.27e-7 Coronary artery disease;Coronary heart disease; CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg09033563 chr22:24373618 LOC391322 -0.43 -5.54 -0.32 7.14e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12325245 0.536 rs35832551 chr16:58591444 G/T cg05725404 chr16:58534157 NDRG4 -0.61 -5.24 -0.31 3.21e-7 Schizophrenia; CESC cis rs4853012 0.887 rs2280644 chr2:74358411 G/A cg05890377 chr2:74357713 NA 0.71 8.95 0.48 6.36e-17 Gestational age at birth (maternal effect); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26875902 chr16:2223324 TRAF7 -0.59 -6.78 -0.38 7.71e-11 Gut microbiome composition (summer); CESC cis rs765787 0.530 rs2413784 chr15:45530516 A/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs17270561 0.779 rs1165200 chr6:25875212 C/T cg16482183 chr6:26056742 HIST1H1C -0.58 -6.89 -0.39 4.13e-11 Iron status biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14320633 chr8:86157573 CA13 -0.53 -6.32 -0.36 1.11e-9 Gut microbiome composition (summer); CESC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg03351412 chr1:154909251 PMVK 0.61 7.84 0.43 1.12e-13 Prostate cancer; CESC cis rs7726839 0.574 rs72707007 chr5:661856 T/C cg16447950 chr5:562315 NA -0.61 -6.43 -0.37 5.93e-10 Obesity-related traits; CESC cis rs28489187 0.660 rs2207368 chr1:85847683 A/G cg16011679 chr1:85725395 C1orf52 0.49 5.8 0.34 1.84e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs10129255 0.536 rs17113249 chr14:107134290 A/G cg07958169 chr14:107095056 NA -0.54 -8.8 -0.48 1.85e-16 Kawasaki disease; CESC cis rs7927771 0.832 rs10838699 chr11:47386073 T/C cg20307385 chr11:47447363 PSMC3 0.59 7.02 0.4 1.91e-11 Subjective well-being; CESC cis rs12931792 0.712 rs56399904 chr16:30166183 C/T cg17640201 chr16:30407289 ZNF48 0.58 8.01 0.44 3.63e-14 Tonsillectomy; CESC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg15921436 chr17:44337874 NA 0.44 5.51 0.32 8.59e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1050631 0.564 rs684890 chr18:33744677 T/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.6 8.4 0.46 2.72e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs6456156 0.774 rs2021999 chr6:167529766 G/C cg07741184 chr6:167504864 NA -0.31 -5.12 -0.3 5.75e-7 Primary biliary cholangitis; CESC cis rs10504073 0.584 rs62507182 chr8:49942500 C/A cg00325661 chr8:49890786 NA 0.56 8.3 0.45 5.47e-15 Blood metabolite ratios; CESC trans rs6991952 0.845 rs7822766 chr8:25742279 A/T cg05977900 chr3:182512126 ATP11B -0.52 -6.5 -0.37 3.87e-10 Inguinal hernia; CESC cis rs8077577 0.895 rs62072468 chr17:18118179 A/G cg16794390 chr17:18148240 FLII 0.41 5.63 0.33 4.55e-8 Obesity-related traits; CESC cis rs7680126 0.632 rs11731464 chr4:10148376 G/A cg00071950 chr4:10020882 SLC2A9 -0.53 -5.53 -0.32 7.73e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg14416269 chr4:6271139 WFS1 0.48 8.11 0.45 1.86e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs477692 0.789 rs568166 chr10:131400088 G/A cg05714579 chr10:131428358 MGMT 0.48 6.37 0.36 8.44e-10 Response to temozolomide; CESC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg08968635 chr6:28129556 ZNF389 0.41 5.28 0.31 2.68e-7 Depression; CESC cis rs7091068 0.616 rs7920366 chr10:95497178 A/T cg20715218 chr10:95462985 C10orf4 0.57 5.36 0.31 1.79e-7 Urinary tract infection frequency; CESC cis rs3806843 0.735 rs2530242 chr5:140053351 G/C cg16179182 chr5:140090404 VTRNA1-1 0.41 5.41 0.32 1.42e-7 Depressive symptoms (multi-trait analysis); CESC cis rs11098499 0.775 rs67281037 chr4:120281157 G/C cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs7605827 0.930 rs3805106 chr2:15535863 C/G cg19274914 chr2:15703543 NA 0.39 6.82 0.39 6e-11 Educational attainment (years of education); CESC cis rs6594499 0.872 rs1379300 chr5:110441439 A/G cg04022379 chr5:110408740 TSLP 0.34 6.17 0.35 2.57e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs77697190 1.000 rs74392582 chr14:103847760 C/T cg09975044 chr14:104007538 NA -0.85 -5.27 -0.31 2.8e-7 Mean corpuscular hemoglobin; CESC cis rs782590 0.967 rs11125579 chr2:55739804 T/C cg18811423 chr2:55921094 PNPT1 0.71 10.88 0.56 4.95e-23 Metabolic syndrome; CESC cis rs17401966 1.000 rs1339458 chr1:10328338 C/T cg15208524 chr1:10270712 KIF1B 0.47 5.97 0.34 7.56e-9 Hepatocellular carcinoma; CESC cis rs2637266 0.703 rs846630 chr10:78536950 G/A cg18941641 chr10:78392320 NA 0.4 7.64 0.42 4.04e-13 Pulmonary function; CESC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg11890956 chr21:40555474 PSMG1 1.17 21.63 0.8 1.74e-60 Cognitive function; CESC cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg05564831 chr3:52568323 NT5DC2 -0.35 -5.15 -0.3 5.12e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 6.08 0.35 4.17e-9 Colorectal cancer; CESC cis rs72945132 0.882 rs11235953 chr11:70184937 C/T cg14191688 chr11:70257035 CTTN 0.43 5.51 0.32 8.64e-8 Coronary artery disease; CESC cis rs910316 0.687 rs175059 chr14:75490667 T/C cg08847533 chr14:75593920 NEK9 -0.91 -16.11 -0.7 3.63e-41 Height; CESC trans rs9467711 0.659 rs35555795 chr6:26509382 C/T cg01620082 chr3:125678407 NA -0.8 -6.23 -0.36 1.86e-9 Autism spectrum disorder or schizophrenia; CESC cis rs1670533 1.000 rs7685541 chr4:1058501 G/A cg04106633 chr4:1044584 NA 0.41 5.17 0.3 4.51e-7 Recombination rate (females); CESC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg06494592 chr3:125709126 NA -0.45 -5.13 -0.3 5.71e-7 Blood pressure (smoking interaction); CESC cis rs3820928 1.000 rs4675120 chr2:227774888 C/T cg11843606 chr2:227700838 RHBDD1 -0.43 -5.81 -0.34 1.74e-8 Pulmonary function; CESC cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg01579765 chr21:45077557 HSF2BP -0.54 -9.0 -0.48 4.61e-17 Mean corpuscular volume; CESC cis rs7927592 0.956 rs11228278 chr11:68308530 G/A cg16797656 chr11:68205561 LRP5 0.42 6.28 0.36 1.39e-9 Total body bone mineral density; CESC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg23708337 chr7:1209742 NA 0.5 5.32 0.31 2.25e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.18 0.3 4.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12188164 0.515 rs11742006 chr5:408529 C/T cg26850624 chr5:429559 AHRR -0.43 -5.46 -0.32 1.08e-7 Cystic fibrosis severity; CESC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.93 9.54 0.51 9.58e-19 Platelet count; CESC cis rs1018836 0.851 rs10808620 chr8:91622940 T/C cg16814680 chr8:91681699 NA -0.77 -11.99 -0.59 9.5e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg18016565 chr1:150552671 MCL1 -0.34 -5.3 -0.31 2.48e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09071690 chr1:59012457 OMA1 0.54 6.03 0.35 5.55e-9 Gut microbiome composition (summer); CESC cis rs9287719 0.967 rs6721514 chr2:10751062 T/C cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs6964587 1.000 rs7800582 chr7:91701346 G/A cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.45e-15 Breast cancer; CESC cis rs7666738 0.819 rs62318904 chr4:99036101 A/T cg05340658 chr4:99064831 C4orf37 0.82 12.42 0.61 3.27e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7937682 0.889 rs479667 chr11:111484034 C/T cg09085632 chr11:111637200 PPP2R1B -0.95 -14.79 -0.67 1.76e-36 Primary sclerosing cholangitis; CESC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg11764359 chr7:65958608 NA 0.94 14.96 0.68 4.3e-37 Aortic root size; CESC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.27e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.744 rs11519905 chr12:38222959 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.63 0.55 3.35e-22 Bladder cancer; CESC trans rs55704346 0.534 rs2271389 chr4:25392728 G/A cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg11987759 chr7:65425863 GUSB -0.46 -6.36 -0.36 9e-10 Aortic root size; CESC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg18190219 chr22:46762943 CELSR1 -0.56 -6.44 -0.37 5.69e-10 LDL cholesterol;Cholesterol, total; CESC cis rs4474465 0.688 rs7937225 chr11:78278126 T/A cg01578073 chr11:78285783 NARS2 -0.45 -5.15 -0.3 5.15e-7 Alzheimer's disease (survival time); CESC cis rs7223966 1.000 rs11079508 chr17:61750066 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.44 0.37 5.7e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg17376030 chr22:41985996 PMM1 -0.77 -8.07 -0.44 2.39e-14 Vitiligo; CESC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg19717773 chr7:2847554 GNA12 -0.57 -8.12 -0.45 1.78e-14 Height; CESC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg15112475 chr7:1198522 ZFAND2A -0.33 -5.26 -0.31 2.9e-7 Longevity;Endometriosis; CESC cis rs3026101 0.671 rs3026145 chr17:5316742 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.17 0.3 4.63e-7 Body mass index; CESC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.53 -7.36 -0.41 2.29e-12 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15470736 chr7:157056012 UBE3C 0.45 6.28 0.36 1.41e-9 Fibrinogen levels; CESC cis rs7071206 1.000 rs7071206 chr10:79401316 C/T cg07817648 chr10:79422355 NA 0.82 10.99 0.56 2.14e-23 Bone mineral density; CESC cis rs1348850 0.668 rs6734426 chr2:178493770 C/T cg22681709 chr2:178499509 PDE11A -0.46 -6.34 -0.36 9.62e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs524281 0.817 rs10896097 chr11:65967953 A/C cg14036092 chr11:66035641 RAB1B -0.5 -5.44 -0.32 1.2e-7 Electroencephalogram traits; CESC cis rs2204008 0.713 rs11173567 chr12:38089375 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.62 0.33 4.73e-8 Bladder cancer; CESC cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg10578991 chr7:12443926 VWDE -0.49 -6.28 -0.36 1.39e-9 Coronary artery disease; CESC cis rs7927771 0.524 rs7129797 chr11:47667167 G/C cg20307385 chr11:47447363 PSMC3 0.62 8.66 0.47 4.63e-16 Subjective well-being; CESC cis rs662064 0.748 rs2480777 chr1:10597551 C/T cg20482658 chr1:10539492 PEX14 0.41 8.41 0.46 2.64e-15 Asthma; CESC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg00149659 chr3:10157352 C3orf10 0.74 9.07 0.49 2.81e-17 Alzheimer's disease; CESC cis rs7914558 1.000 rs7911789 chr10:104756374 T/C cg08650961 chr10:104748594 CNNM2 0.33 5.52 0.32 7.89e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs17376456 0.877 rs13165147 chr5:93422214 G/A cg25358565 chr5:93447407 FAM172A 1.14 11.29 0.57 2.12e-24 Diabetic retinopathy; CESC cis rs796364 0.806 rs11674293 chr2:201026743 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.74 -6.24 -0.36 1.76e-9 Schizophrenia; CESC trans rs8135828 0.770 rs5763301 chr22:29929627 G/A cg17961835 chr3:126195582 ZXDC -0.45 -6.03 -0.35 5.5e-9 Lipid traits; CESC cis rs17039065 0.920 rs7671977 chr4:109435999 T/C cg16022748 chr4:109541635 LOC285456;RPL34 0.67 6.4 0.37 7.14e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.605 rs202638 chr22:41855458 A/G cg06634786 chr22:41940651 POLR3H 0.53 5.9 0.34 1.11e-8 Vitiligo; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg14293102 chr19:2232170 DOT1L 0.46 6.45 0.37 5.23e-10 Thyroid stimulating hormone; CESC cis rs2235642 0.505 rs56359342 chr16:1654948 G/A cg09080909 chr16:1797204 MAPK8IP3 -0.45 -6.08 -0.35 4.08e-9 Coronary artery disease; CESC cis rs2832077 0.506 rs2832085 chr21:30155258 G/T cg08807101 chr21:30365312 RNF160 -0.45 -5.09 -0.3 6.75e-7 Cognitive test performance; CESC cis rs4604732 0.631 rs12091081 chr1:247623064 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 7.52 0.42 8.38e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9487051 0.714 rs7774390 chr6:109602461 C/G cg21918786 chr6:109611834 NA 0.38 5.65 0.33 4.18e-8 Reticulocyte fraction of red cells; CESC cis rs6736093 1.000 rs6755101 chr2:112658964 T/C cg12686935 chr2:112915763 FBLN7 -0.42 -5.17 -0.3 4.56e-7 Coronary artery disease; CESC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg04317338 chr11:64019027 PLCB3 0.55 6.96 0.39 2.68e-11 Platelet count; CESC cis rs965469 1.000 rs2281497 chr20:3258874 G/A cg25506879 chr20:3388711 C20orf194 -0.57 -6.14 -0.35 2.97e-9 IFN-related cytopenia; CESC cis rs7927592 0.672 rs10501398 chr11:68331715 C/G cg20283391 chr11:68216788 NA 0.43 5.55 0.32 6.94e-8 Total body bone mineral density; CESC cis rs870825 0.616 rs67641203 chr4:185623845 A/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs9399401 0.601 rs9321870 chr6:142800758 A/T cg03128060 chr6:142623767 GPR126 0.31 5.41 0.32 1.4e-7 Chronic obstructive pulmonary disease; CESC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg02462569 chr6:150064036 NUP43 -0.35 -5.17 -0.3 4.61e-7 Lung cancer; CESC cis rs10911232 0.524 rs10911229 chr1:183050368 C/G ch.1.3577855R chr1:183094577 LAMC1 0.85 13.7 0.64 1.21e-32 Hypertriglyceridemia; CESC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg18446336 chr7:2847575 GNA12 -0.39 -5.8 -0.34 1.86e-8 Height; CESC cis rs6558174 0.965 rs1564595 chr8:22488939 A/G cg03733263 chr8:22462867 KIAA1967 0.46 6.2 0.36 2.16e-9 Breast cancer; CESC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.46 6.19 0.36 2.25e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4253772 0.591 rs8135363 chr22:46651713 T/C cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.48 5.11 0.3 6.16e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4253772 0.550 rs9615951 chr22:46728056 C/A cg00784671 chr22:46762841 CELSR1 -0.53 -5.69 -0.33 3.35e-8 LDL cholesterol;Cholesterol, total; CESC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg19163074 chr7:65112434 INTS4L2 -0.43 -5.34 -0.31 2e-7 Aortic root size; CESC cis rs225245 0.791 rs720774 chr17:34017453 T/G cg05299278 chr17:33885742 SLFN14 0.39 5.51 0.32 8.44e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs9308433 0.529 rs11800749 chr1:214499754 A/G cg06198575 chr1:214491504 SMYD2 -0.47 -5.77 -0.33 2.19e-8 IgG glycosylation; CESC cis rs7246657 1.000 rs10426297 chr19:37798373 A/G cg23950597 chr19:37808831 NA -0.58 -6.21 -0.36 2.08e-9 Coronary artery calcification; CESC cis rs9583531 0.600 rs6492303 chr13:111356800 G/A cg15841412 chr13:111365552 ING1 0.5 6.51 0.37 3.78e-10 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08853494 chr4:76439657 RCHY1;THAP6 -0.46 -6.06 -0.35 4.74e-9 Fibrinogen levels; CESC cis rs644799 0.526 rs693792 chr11:95622200 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.45 5.75 0.33 2.46e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg06212747 chr3:49208901 KLHDC8B 0.73 9.83 0.52 1.19e-19 Parkinson's disease; CESC cis rs5758659 0.904 rs5758653 chr22:42613485 G/T cg05082376 chr22:42548792 NA -0.37 -5.5 -0.32 8.91e-8 Cognitive function; CESC cis rs2204008 0.749 rs4579984 chr12:38166266 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.69 0.51 3.26e-19 Bladder cancer; CESC cis rs662064 0.926 rs589400 chr1:10561282 A/G cg20482658 chr1:10539492 PEX14 0.39 7.72 0.43 2.4e-13 Asthma; CESC cis rs1707322 1.000 rs4660335 chr1:46474718 C/T cg03146154 chr1:46216737 IPP 0.77 10.4 0.54 1.75e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs62244186 0.541 rs9859879 chr3:44840166 G/A cg15225532 chr3:44803084 KIF15;KIAA1143 0.48 6.24 0.36 1.7e-9 Depressive symptoms; CESC cis rs79349575 0.783 rs56046215 chr17:47008757 A/T cg26022315 chr17:47021804 SNF8 0.39 5.15 0.3 5.04e-7 Type 2 diabetes; CESC cis rs9814567 1.000 rs13090969 chr3:134307257 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.06 0.35 4.58e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6500395 1.000 rs11643264 chr16:48558462 A/G cg04672837 chr16:48644449 N4BP1 0.45 5.21 0.3 3.83e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3862030 0.503 rs6584505 chr10:104254412 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.26 0.41 4.27e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24030037 chr8:27457282 CLU -0.52 -6.05 -0.35 4.98e-9 Gut microbiome composition (summer); CESC cis rs7243790 1.000 rs55756660 chr18:51962984 A/G cg04730925 chr18:51795821 POLI -0.42 -5.54 -0.32 7.12e-8 Diastolic blood pressure; CESC cis rs11583043 0.918 rs3850453 chr1:101408933 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 5.14 0.3 5.35e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs1878931 0.501 rs4785934 chr16:3419934 G/T cg05754148 chr16:3507555 NAT15 -0.38 -5.1 -0.3 6.33e-7 Body mass index (adult); CESC cis rs7017914 0.967 rs6998786 chr8:71694630 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.3 -0.31 2.38e-7 Bone mineral density; CESC cis rs34779708 0.931 rs7079205 chr10:35324619 C/T cg03585969 chr10:35415529 CREM 0.79 10.23 0.53 6.42e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs116095464 0.558 rs59284383 chr5:284525 C/G cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.77e-15 Breast cancer; CESC cis rs2204008 0.837 rs1589395 chr12:38420405 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.71 0.55 1.83e-22 Bladder cancer; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg14802355 chr4:103683140 MANBA 0.47 7.01 0.4 1.97e-11 Thyroid stimulating hormone; CESC cis rs1865721 0.761 rs62089540 chr18:73218332 G/A cg26385618 chr18:73139727 C18orf62 -0.53 -7.75 -0.43 1.94e-13 Intelligence; CESC cis rs763512 0.532 rs3094499 chr17:35891336 A/G cg16670864 chr17:35848621 DUSP14 0.42 5.04 0.3 8.81e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs929354 1.000 rs1182385 chr7:157040583 C/T cg05182265 chr7:156933206 UBE3C 0.42 5.92 0.34 1.01e-8 Body mass index; CESC trans rs6445797 0.632 rs6802051 chr3:56670924 G/A cg15444621 chr13:113611794 NA 0.34 6.08 0.35 4.13e-9 Gastritis; CESC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg00166722 chr3:10149974 C3orf24 0.49 6.04 0.35 5.3e-9 Alzheimer's disease; CESC cis rs9815354 1.000 rs2625668 chr3:41905930 T/C cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg18016565 chr1:150552671 MCL1 -0.35 -5.89 -0.34 1.15e-8 Tonsillectomy; CESC cis rs8002861 0.870 rs12865116 chr13:44440441 C/G cg14210620 chr13:44453864 C13orf31;CCDC122 -0.46 -5.82 -0.34 1.67e-8 Leprosy; CESC cis rs2625529 0.556 rs8038007 chr15:72568043 C/G cg16672083 chr15:72433130 SENP8 0.42 6.26 0.36 1.5e-9 Red blood cell count; CESC cis rs12822507 0.732 rs10492241 chr12:12750509 C/T cg11838227 chr12:12764436 CREBL2 0.41 5.68 0.33 3.46e-8 Systemic lupus erythematosus; CESC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs950169 0.959 rs12902070 chr15:84793558 T/C cg17507749 chr15:85114479 UBE2QP1 0.62 6.82 0.39 6.29e-11 Schizophrenia; CESC cis rs9916302 0.904 rs9894500 chr17:37515735 G/C cg00129232 chr17:37814104 STARD3 0.52 6.49 0.37 4.13e-10 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00049973 chr17:58603597 APPBP2 0.59 6.31 0.36 1.15e-9 Gut microbiome composition (summer); CESC cis rs6987853 0.787 rs2974351 chr8:42407047 A/T cg09913449 chr8:42400586 C8orf40 0.45 7.6 0.42 5.18e-13 Mean corpuscular hemoglobin concentration; CESC cis rs6736093 0.966 rs11683694 chr2:112702647 C/T cg12686935 chr2:112915763 FBLN7 -0.42 -5.46 -0.32 1.1e-7 Coronary artery disease; CESC cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg11752832 chr7:134001865 SLC35B4 0.49 6.27 0.36 1.43e-9 Mean platelet volume; CESC cis rs6032067 1.000 rs6032059 chr20:43852443 A/T cg10761708 chr20:43804764 PI3 0.52 6.26 0.36 1.57e-9 Blood protein levels; CESC cis rs62408225 1.000 rs56106243 chr6:90975990 C/T cg06866423 chr6:90926672 BACH2 0.44 5.36 0.31 1.8e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs644799 0.932 rs480079 chr11:95643777 A/T cg25478527 chr11:95522999 CEP57;FAM76B -0.48 -6.19 -0.36 2.23e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4660306 0.677 rs781061 chr1:45932887 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.17 0.3 4.57e-7 Homocysteine levels; CESC cis rs3857067 0.836 rs12501138 chr4:95098444 T/A cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.01 -0.48 4.22e-17 QT interval; CESC cis rs13242816 1.000 rs17138714 chr7:116114274 C/T cg04696780 chr7:116139425 CAV2 -0.6 -5.36 -0.31 1.78e-7 P wave duration; CESC cis rs11716531 0.512 rs7612312 chr3:27230230 C/A cg02860705 chr3:27208620 NA 0.44 5.91 0.34 1.05e-8 Diastolic blood pressure; CESC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg07507251 chr3:52567010 NT5DC2 0.47 8.71 0.47 3.29e-16 Electroencephalogram traits; CESC cis rs7084402 0.967 rs1649069 chr10:60303695 A/G cg07615347 chr10:60278583 BICC1 -0.59 -9.27 -0.49 6.78e-18 Refractive error; CESC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg11644478 chr21:40555479 PSMG1 -0.55 -7.49 -0.42 1.03e-12 Menarche (age at onset); CESC cis rs6502050 0.835 rs35555954 chr17:80122438 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.25 -0.31 3.18e-7 Life satisfaction; CESC cis rs4253772 0.513 rs6008700 chr22:46722560 C/T cg24881330 chr22:46731750 TRMU 0.92 10.16 0.53 1.06e-20 LDL cholesterol;Cholesterol, total; CESC cis rs250677 0.687 rs250674 chr5:148438597 A/G cg18129178 chr5:148520854 ABLIM3 0.49 5.63 0.33 4.71e-8 Breast cancer; CESC cis rs4523957 0.583 rs2984940 chr17:2023825 A/G cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7584330 0.518 rs13420503 chr2:238437623 G/A cg14458575 chr2:238380390 NA 0.5 5.45 0.32 1.15e-7 Prostate cancer; CESC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg10691866 chr7:65817282 TPST1 -0.34 -5.59 -0.32 5.57e-8 Aortic root size; CESC cis rs12530845 0.887 rs78641973 chr7:135324311 C/T cg23117316 chr7:135346802 PL-5283 -0.47 -5.75 -0.33 2.4e-8 Red blood cell traits; CESC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg17372223 chr3:52568218 NT5DC2 0.41 6.36 0.36 8.74e-10 Bipolar disorder; CESC cis rs2304069 0.507 rs4705407 chr5:149404983 G/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.41 5.79 0.34 1.95e-8 HIV-1 control; CESC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg18240062 chr17:79603768 NPLOC4 -0.72 -10.27 -0.53 4.71e-21 Eye color traits; CESC cis rs7772486 0.875 rs2814869 chr6:146315509 G/A cg23711669 chr6:146136114 FBXO30 0.83 12.06 0.6 5.63e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs477692 0.905 rs489966 chr10:131422115 C/G cg05714579 chr10:131428358 MGMT -0.55 -7.93 -0.44 6.05e-14 Response to temozolomide; CESC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg19077165 chr18:44547161 KATNAL2 -0.65 -9.86 -0.52 9.61e-20 Personality dimensions; CESC cis rs3008870 1.000 rs1137656 chr1:67451602 A/C cg02640540 chr1:67518911 SLC35D1 -0.51 -5.58 -0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg07952391 chr2:88470173 THNSL2 0.64 6.21 0.36 2.05e-9 Plasma clusterin levels; CESC cis rs10899021 0.920 rs12287097 chr11:74332664 A/G cg25880958 chr11:74394337 NA -0.74 -7.86 -0.43 9.71e-14 Response to metformin (IC50); CESC cis rs2439831 0.850 rs7168158 chr15:44050376 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.95 0.44 5.33e-14 Lung cancer in ever smokers; CESC cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg07697082 chr8:82753677 SNX16 0.35 5.39 0.31 1.53e-7 Diastolic blood pressure; CESC cis rs3761218 1.000 rs3761218 chr20:3776175 A/G cg25011176 chr20:3776985 CDC25B 0.47 5.99 0.35 6.87e-9 Bipolar disorder; CESC cis rs4974559 0.790 rs2293631 chr4:1315917 C/A cg02980000 chr4:1222292 CTBP1 0.63 7.18 0.4 7.17e-12 Systolic blood pressure; CESC cis rs12220238 1.000 rs10824110 chr10:75968098 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.44 0.32 1.24e-7 Soluble interleukin-2 receptor subunit alpha; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05573287 chr3:12983221 IQSEC1 0.47 6.67 0.38 1.46e-10 Fibrinogen levels; CESC cis rs16867321 0.614 rs12693245 chr2:181445110 T/C cg23363182 chr2:181467187 NA 0.5 7.38 0.41 2.06e-12 Obesity; CESC cis rs258892 0.895 rs266430 chr5:72125176 A/G cg21869765 chr5:72125136 TNPO1 -0.44 -5.65 -0.33 4.05e-8 Small cell lung carcinoma; CESC cis rs60871478 1.000 rs34086011 chr7:805430 C/T cg27478167 chr7:817139 HEATR2 -0.47 -5.61 -0.33 5.18e-8 Cerebrospinal P-tau181p levels; CESC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg02269571 chr22:50332266 NA -0.57 -6.49 -0.37 4.14e-10 Schizophrenia; CESC cis rs4268898 0.527 rs72789910 chr2:24388609 T/G cg20701182 chr2:24300061 SF3B14 0.75 7.4 0.41 1.79e-12 Asthma; CESC cis rs854765 0.647 rs854808 chr17:18006634 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.52 6.58 0.37 2.53e-10 Total body bone mineral density; CESC cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg19539972 chr4:7069911 GRPEL1 0.63 7.2 0.4 6.25e-12 Monocyte percentage of white cells; CESC trans rs1994135 0.617 rs1384590 chr12:33734271 C/T cg26384229 chr12:38710491 ALG10B 0.46 6.66 0.38 1.57e-10 Resting heart rate; CESC cis rs2439831 0.681 rs1549525 chr15:43627855 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.22 0.63 5.55e-31 Lung cancer in ever smokers; CESC cis rs501120 0.810 rs607592 chr10:44750215 A/G cg09554077 chr10:44749378 NA 0.5 6.65 0.38 1.71e-10 Coronary artery disease;Coronary heart disease; CESC cis rs6121246 0.909 rs1994249 chr20:30287593 C/T cg13852791 chr20:30311386 BCL2L1 0.79 8.3 0.45 5.47e-15 Mean corpuscular hemoglobin; CESC cis rs1348850 0.914 rs1975544 chr2:178465423 G/A cg22681709 chr2:178499509 PDE11A -0.36 -5.05 -0.3 8.05e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2228479 0.850 rs62054610 chr16:89816920 G/A cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20250722 chr6:26522136 HCG11 -0.39 -6.31 -0.36 1.19e-9 Gambling; CESC cis rs3008870 0.755 rs1925409 chr1:67365089 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.62 -8.17 -0.45 1.29e-14 Lymphocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15030636 chr1:246768697 CNST -0.42 -6.42 -0.37 6.32e-10 Gut microbiota (bacterial taxa); CESC cis rs17826219 0.706 rs8075107 chr17:29106649 C/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Body mass index; CESC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs6964587 1.000 rs13239875 chr7:91716104 G/A cg17063962 chr7:91808500 NA 0.57 7.92 0.44 6.54e-14 Breast cancer; CESC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg22974920 chr21:40686053 BRWD1 -0.45 -5.59 -0.32 5.71e-8 Cognitive function; CESC cis rs6460942 0.630 rs62448731 chr7:12341174 G/A cg20607287 chr7:12443886 VWDE -0.58 -6.29 -0.36 1.28e-9 Coronary artery disease; CESC cis rs6088580 0.634 rs6120669 chr20:33105028 T/C cg06115741 chr20:33292138 TP53INP2 0.46 5.97 0.34 7.75e-9 Glomerular filtration rate (creatinine); CESC cis rs9513593 1.000 rs1927724 chr13:99992312 A/C cg21788972 chr13:99853209 UBAC2 0.62 7.04 0.4 1.66e-11 Psoriasis; CESC cis rs11677370 0.603 rs10171309 chr2:3851690 C/T cg17052675 chr2:3827356 NA -0.44 -5.7 -0.33 3.21e-8 Type 2 diabetes; CESC cis rs7116495 1.000 rs610041 chr11:71797968 A/G cg26138937 chr11:71823887 C11orf51 -0.86 -7.03 -0.4 1.75e-11 Severe influenza A (H1N1) infection; CESC cis rs72781680 0.611 rs6720131 chr2:24364736 C/T cg06627628 chr2:24431161 ITSN2 -0.69 -6.54 -0.37 3.23e-10 Lymphocyte counts; CESC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg00166722 chr3:10149974 C3orf24 0.49 6.04 0.35 5.3e-9 Alzheimer's disease; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg07931792 chr19:12707809 ZNF490 0.54 6.47 0.37 4.8e-10 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs4746818 1.000 rs4284308 chr10:70884861 C/T cg04149295 chr10:70884716 VPS26A 0.63 7.0 0.4 2.06e-11 Left atrial antero-posterior diameter; CESC cis rs7071206 0.891 rs10824559 chr10:79409222 A/G cg00983440 chr10:79422392 NA -0.64 -7.31 -0.41 3.08e-12 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10274682 chr19:6496041 TUBB4;MIR220B -0.54 -6.46 -0.37 4.88e-10 Gut microbiome composition (summer); CESC cis rs9303401 0.659 rs11079358 chr17:56920949 G/T cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.45 0.61 2.57e-28 Cognitive test performance; CESC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg04369109 chr6:150039330 LATS1 0.4 5.44 0.32 1.23e-7 Lung cancer; CESC cis rs6493487 0.512 rs17599974 chr15:51237349 C/T cg02338191 chr15:51200825 AP4E1 -0.6 -5.6 -0.33 5.47e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05707844 chr2:37383994 EIF2AK2 -0.45 -6.17 -0.35 2.5e-9 Fibrinogen levels; CESC trans rs7824557 0.564 rs2572379 chr8:11237480 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -6.28 -0.36 1.39e-9 Retinal vascular caliber; CESC cis rs9303401 0.538 rs2240259 chr17:56458129 A/C cg25039879 chr17:56429692 SUPT4H1 0.69 6.9 0.39 3.82e-11 Cognitive test performance; CESC cis rs6942756 0.747 rs598412 chr7:129127736 C/T cg02491457 chr7:128862824 NA 0.55 7.46 0.42 1.24e-12 White matter hyperintensity burden; CESC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg11301795 chr4:187892539 NA -0.75 -12.53 -0.61 1.39e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs2075371 0.611 rs12531769 chr7:134016899 C/G cg11752832 chr7:134001865 SLC35B4 0.43 5.15 0.3 5.2e-7 Mean platelet volume; CESC cis rs72780191 0.574 rs55836224 chr2:23895597 T/C cg20701182 chr2:24300061 SF3B14 0.66 6.94 0.39 3.07e-11 White blood cell count; CESC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg07507251 chr3:52567010 NT5DC2 0.4 6.96 0.39 2.7e-11 Bipolar disorder; CESC cis rs8103278 0.507 rs522769 chr19:46284520 G/A cg11657440 chr19:46296263 DMWD 0.81 12.52 0.61 1.45e-28 Coronary artery disease; CESC cis rs2228479 0.867 rs57940434 chr16:89975496 G/A cg06558623 chr16:89946397 TCF25 0.9 7.89 0.44 7.95e-14 Skin colour saturation; CESC cis rs10751667 0.643 rs10751666 chr11:941933 C/T cg01483505 chr11:975446 AP2A2 0.38 5.18 0.3 4.33e-7 Alzheimer's disease (late onset); CESC cis rs2294693 0.947 rs742492 chr6:40996381 G/A cg14418226 chr6:40996092 UNC5CL 0.53 6.66 0.38 1.59e-10 Gastric cancer;Non-cardia gastric cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16702520 chr1:28157047 PPP1R8 0.58 6.26 0.36 1.56e-9 Gut microbiome composition (summer); CESC cis rs58785573 0.624 rs337605 chr4:38647753 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.51 6.64 0.38 1.8e-10 Lymphocyte percentage of white cells; CESC cis rs9291683 0.588 rs17247314 chr4:10004743 C/G cg11266682 chr4:10021025 SLC2A9 0.64 12.76 0.62 2.09e-29 Bone mineral density; CESC cis rs2952156 0.920 rs8078228 chr17:37834998 C/T cg00129232 chr17:37814104 STARD3 -0.73 -10.6 -0.55 4.07e-22 Asthma; CESC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg08888203 chr3:10149979 C3orf24 0.48 6.2 0.36 2.15e-9 Alzheimer's disease; CESC cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.9 13.31 0.63 2.68e-31 Platelet count; CESC trans rs459571 0.920 rs433402 chr9:136898627 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.6 -7.57 -0.42 6.18e-13 Platelet distribution width; CESC cis rs10751667 0.643 rs12278229 chr11:946985 A/G cg06064525 chr11:970664 AP2A2 -0.49 -9.97 -0.52 4.34e-20 Alzheimer's disease (late onset); CESC cis rs926938 0.520 rs6663115 chr1:115272254 G/A cg12756093 chr1:115239321 AMPD1 -0.54 -6.6 -0.38 2.17e-10 Autism; CESC cis rs4803468 1.000 rs284656 chr19:41929251 T/C cg09537434 chr19:41945824 ATP5SL -1.11 -20.58 -0.78 6.86e-57 Height; CESC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg12463550 chr7:65579703 CRCP 0.57 7.05 0.4 1.52e-11 Aortic root size; CESC cis rs9486715 0.867 rs9372106 chr6:96875058 T/C cg06623918 chr6:96969491 KIAA0776 0.77 11.0 0.56 1.94e-23 Headache; CESC cis rs1580019 0.563 rs13225132 chr7:32800975 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.99 15.33 0.69 2.02e-38 Cognitive ability; CESC cis rs9488822 0.676 rs10456902 chr6:116333742 C/G cg26893134 chr6:116381904 FRK -0.25 -6.23 -0.36 1.78e-9 Cholesterol, total;LDL cholesterol; CESC cis rs6691722 0.503 rs12086212 chr1:24708740 C/T cg18323236 chr1:24743029 NIPAL3 0.42 6.12 0.35 3.44e-9 Response to interferon beta in multiple sclerosis; CESC cis rs2243480 1.000 rs4548056 chr7:65298873 A/G cg13147721 chr7:65941812 NA -0.84 -8.34 -0.46 4.04e-15 Diabetic kidney disease; CESC cis rs870825 0.616 rs7659201 chr4:185632013 G/A cg04058563 chr4:185651563 MLF1IP 0.63 6.89 0.39 3.95e-11 Blood protein levels; CESC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg05368731 chr17:41323189 NBR1 0.76 10.35 0.54 2.73e-21 Menopause (age at onset); CESC cis rs4423214 1.000 rs12797951 chr11:71143266 G/T cg05163923 chr11:71159392 DHCR7 -0.76 -10.52 -0.54 7.5e-22 Vitamin D levels; CESC cis rs1729951 0.575 rs1654904 chr3:136681149 T/C cg03617693 chr3:136751559 NA 0.38 5.31 0.31 2.3e-7 Neuroticism; CESC cis rs9768139 0.935 rs10949715 chr7:158117246 G/T cg25566285 chr7:158114605 PTPRN2 0.54 9.63 0.51 5.14e-19 Calcium levels; CESC cis rs8180040 0.627 rs9821119 chr3:47198437 C/G cg27129171 chr3:47204927 SETD2 0.67 9.81 0.52 1.36e-19 Colorectal cancer; CESC trans rs17536732 0.748 rs1440603 chr4:162816560 T/C cg14364212 chr10:15760690 ITGA8 0.58 6.01 0.35 5.99e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.71 9.96 0.52 4.68e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg04518342 chr5:131593106 PDLIM4 0.41 6.04 0.35 5.13e-9 Breast cancer; CESC cis rs3026101 0.671 rs8081480 chr17:5282761 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.41 5.48 0.32 9.98e-8 Body mass index; CESC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg26818010 chr10:134567672 INPP5A -0.92 -11.19 -0.57 4.64e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4253772 0.832 rs6008259 chr22:46633782 G/A cg09491104 chr22:46646882 C22orf40 -0.56 -8.56 -0.47 9.61e-16 LDL cholesterol;Cholesterol, total; CESC cis rs910316 0.763 rs175450 chr14:75590340 G/A cg08847533 chr14:75593920 NEK9 -0.91 -15.67 -0.69 1.28e-39 Height; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg13837895 chr19:50145301 SCAF1 -0.54 -6.2 -0.36 2.16e-9 Lung cancer in ever smokers; CESC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg20790798 chr5:1857306 NA -0.4 -5.43 -0.32 1.29e-7 Cardiovascular disease risk factors; CESC cis rs7618501 1.000 rs9859153 chr3:49807085 G/T cg24308560 chr3:49941425 MST1R -0.52 -7.18 -0.4 7.15e-12 Intelligence (multi-trait analysis); CESC cis rs60154123 0.730 rs689248 chr1:210463122 A/G cg23283495 chr1:209979779 IRF6 -0.41 -5.32 -0.31 2.18e-7 Coronary artery disease; CESC cis rs483180 0.531 rs539708 chr1:120208503 G/T cg19096424 chr1:120255104 PHGDH -0.43 -5.24 -0.31 3.26e-7 Macular telangiectasia type 2; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01159149 chr11:10830970 EIF4G2 -0.47 -6.44 -0.37 5.5e-10 Height; CESC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg17077180 chr1:38461687 NA 0.56 8.82 0.48 1.6e-16 Coronary artery disease; CESC cis rs9291683 0.526 rs6827785 chr4:10018205 C/T cg11266682 chr4:10021025 SLC2A9 0.68 13.13 0.63 1.13e-30 Bone mineral density; CESC trans rs9858542 0.953 rs9841110 chr3:49492481 C/G cg21659725 chr3:3221576 CRBN -0.55 -6.49 -0.37 4.26e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs3096299 0.933 rs2965939 chr16:89493043 G/A cg08822215 chr16:89438651 ANKRD11 -0.37 -5.57 -0.32 6.17e-8 Multiple myeloma (IgH translocation); CESC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02698600 chr1:201450009 NA 0.57 6.45 0.37 5.4e-10 Gut microbiome composition (summer); CESC cis rs6460942 1.000 rs17274870 chr7:12406221 G/T cg06484146 chr7:12443880 VWDE -0.8 -9.01 -0.48 4.07e-17 Coronary artery disease; CESC cis rs2180341 0.920 rs6906717 chr6:127596782 C/A cg27446573 chr6:127587934 RNF146 1.07 15.98 0.7 1e-40 Breast cancer; CESC cis rs2832191 1.000 rs6516891 chr21:30483070 C/T cg08807101 chr21:30365312 RNF160 -0.67 -9.26 -0.49 7.29e-18 Dental caries; CESC trans rs6600671 0.899 rs2319971 chr1:121226982 A/C cg17023122 chr1:144479586 NA 0.48 6.69 0.38 1.29e-10 Hip geometry; CESC cis rs62229266 0.557 rs4817760 chr21:37395301 T/C cg12218747 chr21:37451666 NA -0.38 -5.27 -0.31 2.8e-7 Mitral valve prolapse; CESC cis rs2072732 0.756 rs12041634 chr1:2951034 A/T cg15211996 chr1:2936768 ACTRT2 0.34 5.95 0.34 8.31e-9 Plateletcrit; CESC cis rs9790314 1.000 rs9850455 chr3:161017192 G/A cg03342759 chr3:160939853 NMD3 -0.5 -6.9 -0.39 3.8e-11 Morning vs. evening chronotype; CESC cis rs4699052 0.507 rs6533085 chr4:104281586 A/T cg16532752 chr4:104119610 CENPE -0.53 -7.04 -0.4 1.62e-11 Testicular germ cell tumor; CESC cis rs858239 0.600 rs28499396 chr7:23124098 A/G cg23682824 chr7:23144976 KLHL7 0.54 7.54 0.42 7.42e-13 Cerebrospinal fluid biomarker levels; CESC cis rs10779751 0.690 rs28729193 chr1:11180151 T/C cg08854313 chr1:11322531 MTOR -0.72 -8.77 -0.47 2.16e-16 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02902800 chr4:6784175 KIAA0232 0.58 6.95 0.39 2.82e-11 Gut microbiome composition (summer); CESC cis rs7216064 1.000 rs8082512 chr17:65837059 T/C cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.73e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs34779708 0.966 rs12775799 chr10:35488264 C/T cg03585969 chr10:35415529 CREM 0.75 9.89 0.52 7.86e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs9814567 1.000 rs1880377 chr3:134270468 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19319069 chr7:129593010 UBE2H -0.47 -6.46 -0.37 4.99e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2404602 0.532 rs206205 chr15:76736091 T/G cg23625390 chr15:77176239 SCAPER 0.35 5.05 0.3 8.18e-7 Blood metabolite levels; CESC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg25072359 chr17:41440525 NA 0.5 6.68 0.38 1.41e-10 Menopause (age at onset); CESC cis rs3749237 0.595 rs2878298 chr3:49406080 T/C cg02487422 chr3:49467188 NICN1 0.55 7.97 0.44 4.74e-14 Resting heart rate; CESC cis rs881375 0.631 rs10739577 chr9:123668854 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.66 0.43 3.56e-13 Rheumatoid arthritis; CESC cis rs11098499 0.908 rs7696649 chr4:120322177 G/A cg24375607 chr4:120327624 NA 0.48 5.83 0.34 1.64e-8 Corneal astigmatism; CESC cis rs7107174 1.000 rs11237438 chr11:77998488 T/C cg02023728 chr11:77925099 USP35 0.48 6.75 0.38 9.5e-11 Testicular germ cell tumor; CESC cis rs2050392 1.000 rs2265185 chr10:30691777 A/C cg18806716 chr10:30721971 MAP3K8 -0.4 -5.8 -0.34 1.87e-8 Inflammatory bowel disease; CESC cis rs4595586 0.655 rs7958206 chr12:39329294 G/A cg26384229 chr12:38710491 ALG10B 0.43 6.31 0.36 1.2e-9 Morning vs. evening chronotype; CESC trans rs2727020 0.617 rs7102702 chr11:49401125 T/G cg03929089 chr4:120376271 NA -0.69 -8.35 -0.46 3.92e-15 Coronary artery disease; CESC cis rs5760092 0.618 rs4461358 chr22:24260106 T/C cg01238044 chr22:24384105 GSTT1 0.66 7.89 0.44 7.87e-14 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg25019033 chr10:957182 NA -0.65 -8.25 -0.45 7.58e-15 Eosinophil percentage of granulocytes; CESC cis rs959260 1.000 rs930298 chr17:73404666 T/G cg12999837 chr17:73267436 MIF4GD -0.49 -5.53 -0.32 7.69e-8 Systemic lupus erythematosus; CESC cis rs8062405 0.755 rs4788078 chr16:28559981 G/A cg01378222 chr16:28622494 SULT1A1 0.3 5.14 0.3 5.27e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs854765 0.583 rs7207395 chr17:17819335 C/T cg04398451 chr17:18023971 MYO15A -0.66 -9.24 -0.49 8.32e-18 Total body bone mineral density; CESC trans rs74054849 0.850 rs72876771 chr1:15999623 C/G cg06826283 chr7:600452 PRKAR1B 0.73 6.06 0.35 4.77e-9 Alcoholic chronic pancreatitis; CESC cis rs2304069 0.779 rs245081 chr5:149356075 G/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.69 9.09 0.49 2.34e-17 HIV-1 control; CESC cis rs17023223 0.509 rs61806978 chr1:119713215 A/G cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs17253792 0.822 rs78522049 chr14:56071203 A/C cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.13 0.3 5.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9291683 0.530 rs35908990 chr4:9976105 G/A cg02734326 chr4:10020555 SLC2A9 0.45 6.77 0.38 8.46e-11 Bone mineral density; CESC cis rs7085104 0.572 rs284856 chr10:104574329 A/T cg23093090 chr10:104574429 C10orf26 0.34 5.41 0.32 1.42e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs12477438 0.520 rs11123766 chr2:99780915 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.73 0.69 8.16e-40 Chronic sinus infection; CESC cis rs7631605 0.905 rs4678920 chr3:37020649 T/C cg22985146 chr3:37219077 LRRFIP2 -0.34 -5.22 -0.31 3.61e-7 Cerebrospinal P-tau181p levels; CESC cis rs12497850 0.966 rs6792510 chr3:48723302 G/C cg07636037 chr3:49044803 WDR6 0.92 14.61 0.67 7.14e-36 Parkinson's disease; CESC cis rs854765 0.583 rs67253360 chr17:17828973 T/C cg16928487 chr17:17741425 SREBF1 -0.57 -9.74 -0.51 2.41e-19 Total body bone mineral density; CESC cis rs2294693 0.947 rs9381025 chr6:40986623 C/T cg14418226 chr6:40996092 UNC5CL 0.43 5.47 0.32 1.07e-7 Gastric cancer;Non-cardia gastric cancer; CESC trans rs7980799 0.682 rs7138529 chr12:33634855 T/C cg26384229 chr12:38710491 ALG10B -0.59 -8.62 -0.47 6.34e-16 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg17221315 chr6:27791827 HIST1H4J 0.43 5.03 0.3 9.18e-7 Depression; CESC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg18230493 chr5:56204884 C5orf35 -0.75 -8.9 -0.48 9.02e-17 Initial pursuit acceleration; CESC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.77 -10.18 -0.53 9.33e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11608355 0.521 rs6606703 chr12:109813665 C/T cg19025524 chr12:109796872 NA -0.53 -7.76 -0.43 1.83e-13 Neuroticism; CESC cis rs11945232 1.000 rs11945232 chr4:88342369 A/G cg23841344 chr4:88312519 HSD17B11 -0.47 -6.01 -0.35 6.2e-9 Intelligence (multi-trait analysis); CESC cis rs7605827 0.930 rs12692275 chr2:15716781 C/T cg19274914 chr2:15703543 NA 0.37 6.62 0.38 1.96e-10 Educational attainment (years of education); CESC cis rs12681288 0.712 rs2600488 chr8:1021266 A/C cg04851639 chr8:1020857 NA -0.32 -7.17 -0.4 7.38e-12 Schizophrenia; CESC cis rs72781680 0.898 rs12620558 chr2:23936022 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.91 0.39 3.5e-11 Lymphocyte counts; CESC cis rs10979 0.964 rs35826562 chr6:143898672 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.12 -0.49 1.91e-17 Hypospadias; CESC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 10.55 0.54 5.87e-22 Platelet count; CESC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg24881330 chr22:46731750 TRMU 0.79 6.42 0.37 6.34e-10 LDL cholesterol;Cholesterol, total; CESC cis rs6426558 0.537 rs6692080 chr1:227390162 C/T cg10327440 chr1:227177885 CDC42BPA -0.48 -5.91 -0.34 1.07e-8 Neutrophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20304750 chr12:124821387 NCOR2 0.48 6.11 0.35 3.49e-9 Fibrinogen levels; CESC cis rs113835537 0.559 rs57045447 chr11:66339683 A/G cg24851651 chr11:66362959 CCS 0.5 5.96 0.34 7.95e-9 Airway imaging phenotypes; CESC cis rs938554 0.570 rs7696983 chr4:9995829 A/C cg11266682 chr4:10021025 SLC2A9 0.52 6.87 0.39 4.48e-11 Blood metabolite levels; CESC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.59 6.95 0.39 2.9100000000000002e-11 Menopause (age at onset); CESC cis rs7044106 0.512 rs7873848 chr9:123354222 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 11.72 0.58 7.93e-26 Hip circumference adjusted for BMI; CESC cis rs1003719 0.788 rs2006941 chr21:38467616 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.42 0.32 1.37e-7 Personality dimensions; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09174674 chr1:9884042 CLSTN1 -0.47 -6.18 -0.35 2.4e-9 Fibrinogen levels; CESC cis rs1538970 0.774 rs67683090 chr1:45977803 T/G cg05343316 chr1:45956843 TESK2 0.93 12.78 0.62 1.91e-29 Platelet count; CESC cis rs7666738 0.830 rs17026973 chr4:98680041 T/A cg03467027 chr4:99064603 C4orf37 0.44 5.39 0.31 1.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg07701084 chr6:150067640 NUP43 0.47 6.77 0.38 8.49e-11 Lung cancer; CESC trans rs62103177 0.810 rs3902996 chr18:77630571 A/G cg05926928 chr17:57297772 GDPD1 1.14 9.88 0.52 8.43e-20 Opioid sensitivity; CESC cis rs7116495 0.609 rs4945378 chr11:71668866 G/A cg10381502 chr11:71823885 C11orf51 -1.1 -7.6 -0.42 5.21e-13 Severe influenza A (H1N1) infection; CESC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg17005319 chr11:655579 DEAF1 0.53 5.16 0.3 4.76e-7 Systemic lupus erythematosus; CESC cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg13798912 chr7:905769 UNC84A -0.55 -5.28 -0.31 2.64e-7 Cerebrospinal P-tau181p levels; CESC cis rs28489187 0.706 rs233069 chr1:85805466 C/T cg16011679 chr1:85725395 C1orf52 0.48 5.6 0.33 5.29e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs17292804 0.506 rs71417868 chr14:104046592 A/T cg24130564 chr14:104152367 KLC1 -0.5 -6.38 -0.36 7.92e-10 Autism spectrum disorder or schizophrenia; CESC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg10253484 chr15:75165896 SCAMP2 -0.51 -6.94 -0.39 2.93e-11 Breast cancer; CESC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg24675658 chr1:53192096 ZYG11B 0.53 6.69 0.38 1.29e-10 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00226754 chr12:124068984 TMED2 0.55 6.49 0.37 4.1e-10 Gut microbiome composition (summer); CESC cis rs684232 0.543 rs4968095 chr17:507539 A/G cg12384639 chr17:618140 VPS53 0.4 5.14 0.3 5.42e-7 Prostate cancer; CESC trans rs11098499 0.739 rs4833612 chr4:120147596 A/C cg25214090 chr10:38739885 LOC399744 -0.56 -7.5 -0.42 9.44e-13 Corneal astigmatism; CESC cis rs6963495 0.818 rs55922564 chr7:105155890 G/A cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs367943 1.000 rs348952 chr5:112821990 G/T cg12552261 chr5:112820674 MCC -0.63 -7.96 -0.44 4.96e-14 Type 2 diabetes; CESC cis rs9858542 0.953 rs11922013 chr3:49458355 G/C cg07274523 chr3:49395745 GPX1 0.67 8.23 0.45 8.41e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg27297192 chr10:134578999 INPP5A 0.39 5.08 0.3 7.26e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs10838798 0.517 rs1967210 chr11:48096692 G/T cg15704280 chr7:45808275 SEPT13 -0.57 -6.02 -0.35 5.72e-9 Height; CESC cis rs524023 1.000 rs3825018 chr11:64358809 G/A cg07220939 chr11:64358617 SLC22A12 -0.35 -5.46 -0.32 1.09e-7 Urate levels in obese individuals; CESC cis rs1348850 0.526 rs10497504 chr2:178370040 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.69 6.19 0.36 2.22e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.0 10.3 0.53 3.82e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6732160 0.574 rs7557055 chr2:73472670 G/A cg01422370 chr2:73384389 NA 0.43 7.25 0.41 4.71e-12 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02375201 chr1:27114675 PIGV -0.47 -6.09 -0.35 3.87e-9 Fibrinogen levels; CESC cis rs1348850 0.872 rs4893959 chr2:178400204 G/A cg22681709 chr2:178499509 PDE11A -0.46 -6.69 -0.38 1.34e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs854765 0.856 rs2955382 chr17:17947710 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.42 -5.76 -0.33 2.28e-8 Total body bone mineral density; CESC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg26338869 chr17:61819248 STRADA 0.67 8.77 0.47 2.24e-16 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01274715 chr10:92618033 HTR7 -0.48 -6.19 -0.36 2.29e-9 Gut microbiome composition (summer); CESC cis rs9788682 0.642 rs2568483 chr15:78752343 A/G cg24631222 chr15:78858424 CHRNA5 0.6 6.97 0.39 2.47e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs36051895 0.623 rs7035456 chr9:5261440 G/A cg02405213 chr9:5042618 JAK2 -0.54 -6.66 -0.38 1.57e-10 Pediatric autoimmune diseases; CESC cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg04455712 chr21:45112962 RRP1B 0.49 7.37 0.41 2.13e-12 Mean corpuscular volume; CESC cis rs806215 0.950 rs3735644 chr7:127222157 G/A cg25922125 chr7:127225783 GCC1 -0.45 -5.04 -0.3 8.61e-7 Type 2 diabetes; CESC cis rs62103177 0.810 rs3902996 chr18:77630571 A/G cg12964065 chr18:77638022 KCNG2 0.56 5.45 0.32 1.12e-7 Opioid sensitivity; CESC cis rs854765 0.583 rs8073001 chr17:17831716 A/C cg04398451 chr17:18023971 MYO15A 0.65 9.41 0.5 2.56e-18 Total body bone mineral density; CESC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs9549260 0.755 rs2721067 chr13:41156708 C/T cg21288729 chr13:41239152 FOXO1 0.61 7.57 0.42 6.17e-13 Red blood cell count; CESC cis rs6575793 0.967 rs11845605 chr14:101037726 C/T cg18516195 chr14:101012996 BEGAIN -0.45 -6.27 -0.36 1.47e-9 Menarche (age at onset); CESC cis rs4969178 0.965 rs938351 chr17:76399404 C/T cg05887092 chr17:76393375 PGS1 0.59 9.4 0.5 2.73e-18 HDL cholesterol levels; CESC cis rs2204008 0.775 rs8186812 chr12:38305055 C/T cg13010199 chr12:38710504 ALG10B 0.42 5.39 0.31 1.58e-7 Bladder cancer; CESC cis rs1707322 1.000 rs785480 chr1:46492164 C/G cg03146154 chr1:46216737 IPP 0.71 9.64 0.51 4.73e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs778371 0.723 rs737027 chr2:233641083 G/C cg08000102 chr2:233561755 GIGYF2 0.83 14.42 0.66 3.32e-35 Schizophrenia; CESC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.01 0.56 1.86e-23 Alzheimer's disease; CESC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg18904891 chr8:8559673 CLDN23 -0.44 -5.41 -0.32 1.44e-7 Mood instability; CESC cis rs644799 1.000 rs611020 chr11:95567905 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.68 8.53 0.46 1.18e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4481887 0.893 rs10788763 chr1:248429070 A/T cg00666640 chr1:248458726 OR2T12 -0.31 -5.83 -0.34 1.59e-8 Common traits (Other); CESC cis rs1728785 1.000 rs864741 chr16:68576577 C/T cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg04342999 chr5:138629163 MATR3 -0.41 -6.05 -0.35 4.92e-9 Vertical cup-disc ratio; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25978167 chr4:57301353 PAICS;PPAT -0.43 -6.04 -0.35 5.08e-9 Gambling; CESC cis rs1008375 1.000 rs13119927 chr4:17691640 G/A cg16339924 chr4:17578868 LAP3 -0.66 -7.92 -0.44 6.43e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7100689 0.697 rs4934084 chr10:82116960 T/C cg00277334 chr10:82204260 NA -0.59 -7.35 -0.41 2.39e-12 Post bronchodilator FEV1; CESC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg24549020 chr5:56110836 MAP3K1 0.64 7.46 0.42 1.26e-12 Initial pursuit acceleration; CESC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg04553112 chr3:125709451 NA -0.5 -5.81 -0.34 1.78e-8 Blood pressure (smoking interaction); CESC cis rs2425143 0.908 rs6060625 chr20:34414318 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.7 -6.18 -0.35 2.41e-9 Blood protein levels; CESC trans rs7980799 0.935 rs1905408 chr12:33516963 G/A cg26384229 chr12:38710491 ALG10B -0.47 -6.44 -0.37 5.7e-10 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg01324507 chr7:1177794 C7orf50 0.53 5.09 0.3 6.72e-7 Bronchopulmonary dysplasia; CESC cis rs2274273 0.686 rs57033289 chr14:55623317 C/A cg04306507 chr14:55594613 LGALS3 0.31 5.26 0.31 2.99e-7 Protein biomarker; CESC cis rs950169 0.922 rs11638445 chr15:85137694 C/A cg17507749 chr15:85114479 UBE2QP1 0.54 6.18 0.35 2.45e-9 Schizophrenia; CESC cis rs2455799 0.613 rs4684261 chr3:15796505 G/A cg16303742 chr3:15540471 COLQ -0.39 -6.14 -0.35 3.01e-9 Mean platelet volume; CESC cis rs2191566 0.960 rs8105571 chr19:44510341 C/T cg20607764 chr19:44506953 ZNF230 -0.59 -7.6 -0.42 5.2e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs11690935 0.959 rs6705200 chr2:172637600 A/G cg13550731 chr2:172543902 DYNC1I2 -1.02 -16.98 -0.72 2.91e-44 Schizophrenia; CESC cis rs4728302 0.559 rs7779409 chr7:133158475 A/G cg10665199 chr7:133106180 EXOC4 0.54 7.47 0.42 1.17e-12 Intelligence;Intelligence (multi-trait analysis); CESC cis rs1348850 0.914 rs4893938 chr2:178250095 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.83 12.0 0.59 8.46e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7584330 0.518 rs11903073 chr2:238432766 C/T cg14458575 chr2:238380390 NA 0.48 5.31 0.31 2.37e-7 Prostate cancer; CESC cis rs6460942 1.000 rs2053378 chr7:12405564 C/G cg10578991 chr7:12443926 VWDE -0.55 -5.86 -0.34 1.36e-8 Coronary artery disease; CESC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg19592336 chr6:28129416 ZNF389 0.61 7.98 0.44 4.44e-14 Depression; CESC cis rs6502050 0.787 rs7222326 chr17:80057272 T/C cg11859384 chr17:80120422 CCDC57 0.39 5.05 0.3 8.31e-7 Life satisfaction; CESC cis rs7605827 0.930 rs2052439 chr2:15702029 C/G cg19274914 chr2:15703543 NA 0.36 6.44 0.37 5.68e-10 Educational attainment (years of education); CESC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg22920501 chr2:26401640 FAM59B 0.71 7.02 0.4 1.83e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25195100 chr20:61903949 ARFGAP1 0.63 7.46 0.42 1.24e-12 Gut microbiome composition (summer); CESC cis rs10791323 0.569 rs2282601 chr11:133712594 C/G cg15485101 chr11:133734466 NA 0.4 6.51 0.37 3.65e-10 Childhood ear infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25004679 chr17:74722398 C17orf95;JMJD6 0.59 6.86 0.39 4.76e-11 Gut microbiome composition (summer); CESC cis rs6484504 0.600 rs942272 chr11:31364368 C/T cg14844989 chr11:31128820 NA 0.39 5.25 0.31 3.13e-7 Red blood cell count; CESC cis rs3820068 0.581 rs1547031 chr1:15918960 G/A cg17385448 chr1:15911702 AGMAT 0.44 7.11 0.4 1.08e-11 Systolic blood pressure; CESC cis rs950169 0.922 rs4842939 chr15:84827966 C/T cg17507749 chr15:85114479 UBE2QP1 -0.49 -5.81 -0.34 1.81e-8 Schizophrenia; CESC cis rs585510 1 rs585510 chr12:121000133 A/G cg12219531 chr12:120966889 COQ5 0.75 9.92 0.52 6.36e-20 Reticulocyte fraction of red cells; CESC cis rs3806843 0.966 rs2563255 chr5:140142547 T/C cg26395211 chr5:140044315 WDR55 0.39 5.17 0.3 4.51e-7 Depressive symptoms (multi-trait analysis); CESC cis rs4535700 0.501 rs9642405 chr7:55978166 C/T cg09872392 chr7:56161020 PHKG1 0.41 6.03 0.35 5.59e-9 Macular telangiectasia type 2; CESC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg27121462 chr16:89883253 FANCA 0.75 10.66 0.55 2.66e-22 Vitiligo; CESC trans rs4332037 0.539 rs57148375 chr7:2025001 G/C cg11693508 chr17:37793320 STARD3 0.67 6.73 0.38 1.07e-10 Bipolar disorder; CESC cis rs782590 0.764 rs935177 chr2:55826761 C/G cg18811423 chr2:55921094 PNPT1 0.77 12.1 0.6 4.01e-27 Metabolic syndrome; CESC trans rs2727020 0.729 rs34647977 chr11:49195543 G/A cg15704280 chr7:45808275 SEPT13 -0.84 -13.72 -0.64 9.55e-33 Coronary artery disease; CESC cis rs9811920 0.683 rs7650727 chr3:99688976 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -6.29 -0.36 1.3e-9 Axial length; CESC cis rs7000551 0.556 rs6998780 chr8:22254639 C/T cg12081754 chr8:22256438 SLC39A14 0.89 12.19 0.6 1.95e-27 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs244293 0.760 rs4794547 chr17:53011172 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.48 -6.57 -0.37 2.63e-10 Menarche (age at onset); CESC trans rs3808502 0.549 rs7831039 chr8:11427637 A/T cg15556689 chr8:8085844 FLJ10661 -0.57 -6.81 -0.39 6.66e-11 Neuroticism; CESC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg07395648 chr5:131743802 NA -0.41 -5.23 -0.31 3.51e-7 Blood metabolite levels; CESC cis rs10392 0.543 rs4812333 chr20:37536119 T/A cg27552599 chr20:37590471 DHX35 0.38 5.38 0.31 1.61e-7 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg23161317 chr6:28129485 ZNF389 0.41 5.59 0.32 5.75e-8 Cardiac Troponin-T levels; CESC cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg04234412 chr22:24373322 LOC391322 -0.73 -11.52 -0.58 3.52e-25 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4604732 0.536 rs7528219 chr1:247628307 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.09 0.3 6.91e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2540647 0.908 rs2023634 chr22:18972450 C/T cg12798833 chr22:18958832 DGCR5 -0.63 -7.65 -0.43 3.73e-13 Blood metabolite ratios; CESC cis rs3125734 0.633 rs1864836 chr10:64028538 C/G cg09941381 chr10:64027924 RTKN2 -0.31 -5.11 -0.3 6.26e-7 Rheumatoid arthritis; CESC cis rs7208859 0.623 rs9914242 chr17:29216245 G/T cg19761014 chr17:28927070 LRRC37B2 0.66 5.51 0.32 8.42e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10227393 chr19:3721525 NA -0.49 -6.62 -0.38 1.97e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7580658 0.724 rs6712551 chr2:127998485 G/A cg10021288 chr2:128175891 PROC -0.39 -6.1 -0.35 3.69e-9 Protein C levels; CESC cis rs614226 0.744 rs787832 chr12:120986801 A/G cg01236616 chr12:121019343 POP5 1.55 19.98 0.78 8.29e-55 Type 1 diabetes nephropathy; CESC cis rs3916 0.911 rs2239758 chr12:121162637 A/G cg21892295 chr12:121157589 UNC119B -0.36 -5.33 -0.31 2.1e-7 Urinary metabolites (H-NMR features); CESC cis rs8077577 0.895 rs62072498 chr17:18125951 C/G cg16794390 chr17:18148240 FLII 0.43 5.85 0.34 1.44e-8 Obesity-related traits; CESC cis rs6762477 0.505 rs17304079 chr3:50085153 A/G cg03060546 chr3:49711283 APEH -0.44 -5.06 -0.3 7.7300000000000005e-07 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03657549 chr7:128116813 METTL2B 0.51 6.05 0.35 4.8e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26257210 chr1:6305348 HES3 0.55 6.49 0.37 4.29e-10 Gut microbiome composition (summer); CESC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg24060327 chr5:131705240 SLC22A5 -0.78 -10.95 -0.56 2.89e-23 Breast cancer; CESC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07881228 chr7:30068068 PLEKHA8 0.57 6.86 0.39 4.93e-11 Gut microbiome composition (summer); CESC cis rs7178909 0.872 rs17241560 chr15:90429202 T/A cg19708238 chr15:90437601 AP3S2 0.36 5.03 0.3 9.01e-7 Common traits (Other); CESC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.12 0.81 3.99e-62 Prudent dietary pattern; CESC trans rs10411161 0.702 rs16983200 chr19:52386723 G/A cg22319618 chr22:45562946 NUP50 -0.73 -7.14 -0.4 8.9e-12 Breast cancer; CESC cis rs9640161 0.750 rs11538922 chr7:150035183 C/T cg10018233 chr7:150070692 REPIN1 0.47 6.82 0.39 6.1e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs6987853 0.736 rs2923446 chr8:42404177 G/A cg09913449 chr8:42400586 C8orf40 0.45 7.63 0.42 4.28e-13 Mean corpuscular hemoglobin concentration; CESC cis rs360798 0.532 rs1022110 chr2:63046039 T/G cg17519650 chr2:63277830 OTX1 -0.47 -5.59 -0.32 5.52e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21640038 chr17:65362901 PSMD12 -0.61 -6.67 -0.38 1.48e-10 Gut microbiome composition (summer); CESC cis rs6456156 0.792 rs10946212 chr6:167515947 C/G cg23791538 chr6:167370224 RNASET2 -0.41 -5.35 -0.31 1.87e-7 Primary biliary cholangitis; CESC cis rs7000551 0.505 rs13258195 chr8:22227271 A/G cg02463440 chr8:22132932 PIWIL2 -0.41 -5.03 -0.3 9.07e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg18876405 chr7:65276391 NA 0.51 5.88 0.34 1.25e-8 Aortic root size; CESC cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg02773041 chr1:40204384 PPIE 0.53 7.56 0.42 6.49e-13 Blood protein levels; CESC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg22105103 chr4:187893119 NA -0.48 -6.74 -0.38 9.77e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs17826219 0.568 rs2626985 chr17:29077437 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Body mass index; CESC cis rs453301 0.653 rs7853 chr8:8890814 A/G cg06636001 chr8:8085503 FLJ10661 0.48 6.06 0.35 4.7e-9 Joint mobility (Beighton score); CESC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg09699651 chr6:150184138 LRP11 0.4 5.18 0.3 4.32e-7 Lung cancer; CESC cis rs2439831 0.850 rs28696802 chr15:44140395 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.66 6.03 0.35 5.4e-9 Lung cancer in ever smokers; CESC cis rs2050392 0.590 rs694346 chr10:30711929 C/T cg02070205 chr10:30722105 MAP3K8 -0.45 -5.24 -0.31 3.32e-7 Inflammatory bowel disease; CESC cis rs7666738 0.515 rs10015315 chr4:98700137 A/G cg05340658 chr4:99064831 C4orf37 0.58 7.23 0.41 5.32e-12 Colonoscopy-negative controls vs population controls; CESC cis rs7542091 0.704 rs1883331 chr1:210043483 A/G cg09509183 chr1:209979624 IRF6 0.4 5.78 0.33 2.12e-8 Monobrow; CESC cis rs55728055 0.661 rs61561528 chr22:31983071 A/G cg01338084 chr22:32026380 PISD 1.22 8.02 0.44 3.48e-14 Age-related hearing impairment; CESC cis rs1775715 0.835 rs113450267 chr10:32223728 G/A cg18675610 chr10:32216311 ARHGAP12 0.33 5.06 0.3 7.93e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs826838 0.935 rs1684407 chr12:39127270 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.53e-9 Heart rate; CESC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg17143192 chr8:8559678 CLDN23 -0.47 -5.89 -0.34 1.19e-8 Mood instability; CESC cis rs2204008 0.806 rs1589382 chr12:38408565 T/A cg26384229 chr12:38710491 ALG10B 0.69 10.57 0.54 4.96e-22 Bladder cancer; CESC trans rs9951602 0.512 rs9955812 chr18:76650954 T/A cg02800362 chr5:177631904 HNRNPAB 0.66 8.66 0.47 4.55e-16 Obesity-related traits; CESC cis rs7178572 0.568 rs12905951 chr15:77649431 G/A cg22256960 chr15:77711686 NA -0.54 -6.83 -0.39 5.83e-11 Type 2 diabetes; CESC cis rs2228479 0.702 rs62052710 chr16:89854893 C/T cg06558623 chr16:89946397 TCF25 1.18 9.44 0.5 1.97e-18 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22508203 chr13:97762289 NA 0.59 6.58 0.37 2.54e-10 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13081381 chr13:82264192 NA -0.47 -6.53 -0.37 3.43e-10 Gut microbiota (bacterial taxa); CESC cis rs938554 0.737 rs11723439 chr4:9951819 C/T cg11266682 chr4:10021025 SLC2A9 -0.5 -6.13 -0.35 3.13e-9 Blood metabolite levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg08496016 chr9:99181722 ZNF367 -0.44 -6.09 -0.35 4.01e-9 Height; CESC cis rs2243480 0.803 rs36004293 chr7:65416512 T/C cg12463550 chr7:65579703 CRCP 0.69 5.72 0.33 2.85e-8 Diabetic kidney disease; CESC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg26343298 chr8:95960752 TP53INP1 0.36 5.91 0.34 1.06e-8 Type 2 diabetes; CESC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg24562669 chr7:97807699 LMTK2 0.48 7.05 0.4 1.52e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs1707322 0.721 rs28817701 chr1:46186050 C/T cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs561341 1.000 rs117979353 chr17:30272866 A/G cg20587970 chr11:113659929 NA -1.48 -19.43 -0.77 7.1e-53 Hip circumference adjusted for BMI; CESC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.69 0.33 3.35e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg08470875 chr2:26401718 FAM59B 0.59 6.11 0.35 3.53e-9 Gut microbiome composition (summer); CESC cis rs2243480 0.808 rs12698508 chr7:65411958 A/T cg18252515 chr7:66147081 NA -1.23 -11.49 -0.58 4.61e-25 Diabetic kidney disease; CESC cis rs3091242 0.933 rs3093584 chr1:25668714 T/C cg27572855 chr1:25598939 RHD -0.44 -7.23 -0.41 5.25e-12 Erythrocyte sedimentation rate; CESC cis rs8016982 0.674 rs11159494 chr14:81667611 G/C cg01989461 chr14:81687754 GTF2A1 0.75 11.83 0.59 3.33e-26 Schizophrenia; CESC cis rs899997 1.000 rs11634628 chr15:79005579 G/A cg04896959 chr15:78267971 NA 0.42 6.32 0.36 1.09e-9 Coronary artery disease or large artery stroke; CESC cis rs7520050 0.807 rs28647556 chr1:46206399 G/A cg24296786 chr1:45957014 TESK2 -0.46 -5.98 -0.34 7.23e-9 Red blood cell count;Reticulocyte count; CESC cis rs12893668 0.608 rs12889721 chr14:104034863 C/T cg24130564 chr14:104152367 KLC1 -0.52 -6.62 -0.38 1.98e-10 Reticulocyte count; CESC cis rs1941023 0.584 rs2241920 chr11:60164204 A/G cg08716584 chr11:60157161 MS4A7 0.57 9.45 0.5 1.94e-18 Congenital heart disease (maternal effect); CESC cis rs10883723 0.810 rs2296590 chr10:104262628 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs4450798 0.649 rs9310430 chr3:13781682 A/G cg05589046 chr3:13742034 LOC285375 0.34 5.09 0.3 6.68e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg18230493 chr5:56204884 C5orf35 -0.74 -8.84 -0.48 1.37e-16 Initial pursuit acceleration; CESC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg02725872 chr8:58115012 NA -0.38 -5.1 -0.3 6.54e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07555597 chr2:62423100 B3GNT2 0.65 8.15 0.45 1.43e-14 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg19468946 chr17:37922297 IKZF3 0.41 5.22 0.31 3.59e-7 Glomerular filtration rate (creatinine); CESC cis rs1728785 1.000 rs1170426 chr16:68603798 C/T cg02972257 chr16:68554789 NA -0.59 -6.71 -0.38 1.2e-10 Ulcerative colitis; CESC cis rs7223966 1.000 rs11871767 chr17:61698723 A/G cg11494091 chr17:61959527 GH2 0.38 5.06 0.3 7.99e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7274811 0.744 rs6120309 chr20:32169600 A/G cg21523528 chr20:32077966 CBFA2T2 0.44 5.37 0.31 1.73e-7 Height; CESC cis rs7071206 0.853 rs114936111 chr10:79430143 G/A cg23888215 chr10:79422304 NA -0.5 -5.71 -0.33 2.99e-8 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27634258 chr15:51058042 SPPL2A 0.65 7.68 0.43 3.06e-13 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.17e-12 Tonsillectomy; CESC cis rs7618501 0.699 rs2681780 chr3:49897830 C/T cg24308560 chr3:49941425 MST1R -0.69 -10.26 -0.53 5.27e-21 Intelligence (multi-trait analysis); CESC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg26314531 chr2:26401878 FAM59B 0.84 9.25 0.49 7.65e-18 Gut microbiome composition (summer); CESC cis rs10479542 0.503 rs12719865 chr5:178993566 C/T cg05457628 chr5:178986728 RUFY1 0.51 7.51 0.42 8.99e-13 Lung cancer; CESC cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.1 0.3 6.43e-7 Hip circumference adjusted for BMI; CESC cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg22467129 chr15:76604101 ETFA -0.38 -5.78 -0.33 2.11e-8 Blood metabolite levels; CESC trans rs17039212 0.522 rs12620068 chr2:49905093 A/C cg10837625 chr15:45428812 DUOX1 0.89 7.19 0.4 6.76e-12 Systemic lupus erythematosus; CESC cis rs2276314 0.857 rs56230698 chr18:33628885 A/G cg05985134 chr18:33552581 C18orf21 0.62 7.21 0.4 5.98e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs854765 0.505 rs2955358 chr17:17946623 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.54 -7.2 -0.4 6.22e-12 Total body bone mineral density; CESC cis rs5753618 0.504 rs9609329 chr22:31966313 A/C cg13145458 chr22:31556086 RNF185 -0.5 -5.82 -0.34 1.7e-8 Colorectal cancer; CESC cis rs17601876 0.814 rs11632903 chr15:51564341 C/T cg19946085 chr15:51559439 CYP19A1 -0.32 -5.13 -0.3 5.67e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs644799 0.710 rs10831433 chr11:95519787 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.72 0.58 7.56e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs921968 0.541 rs664514 chr2:219329819 A/G cg02176678 chr2:219576539 TTLL4 0.5 8.91 0.48 8.53e-17 Mean corpuscular hemoglobin concentration; CESC cis rs4132509 0.843 rs12034588 chr1:243784392 T/A cg21452805 chr1:244014465 NA 0.46 5.07 0.3 7.49e-7 RR interval (heart rate); CESC cis rs3820068 0.705 rs4645992 chr1:15849742 G/T cg17385448 chr1:15911702 AGMAT 0.41 6.13 0.35 3.19e-9 Systolic blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18113596 chr7:57247912 LOC642006 0.39 6.83 0.39 5.92e-11 Fibrinogen levels; CESC cis rs2439831 0.850 rs12442297 chr15:44168470 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.65 6.65 0.38 1.62e-10 Lung cancer in ever smokers; CESC cis rs3748682 0.861 rs2291297 chr1:38272660 G/A cg12658694 chr1:38397304 INPP5B 0.5 5.04 0.3 8.66e-7 Hypothyroidism; CESC cis rs7267979 1.000 rs884613 chr20:25288505 C/T cg08601574 chr20:25228251 PYGB -0.36 -5.09 -0.3 6.75e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs9611565 0.559 rs132761 chr22:42004371 C/T cg17376030 chr22:41985996 PMM1 -0.8 -8.91 -0.48 8.68e-17 Vitiligo; CESC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg18758796 chr5:131593413 PDLIM4 -0.41 -5.74 -0.33 2.61e-8 Breast cancer; CESC cis rs8072100 0.713 rs4968228 chr17:45497548 T/C cg08085267 chr17:45401833 C17orf57 -0.52 -6.6 -0.38 2.28e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1003719 0.715 rs35199609 chr21:38510262 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.56 -0.47 9.46e-16 Eye color traits; CESC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg25767906 chr1:53392781 SCP2 0.53 7.72 0.43 2.46e-13 Monocyte count; CESC trans rs10435719 0.805 rs13269417 chr8:11791962 C/T cg15556689 chr8:8085844 FLJ10661 0.53 6.57 0.37 2.72e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs9488822 0.676 rs13194714 chr6:116394819 T/A cg18764771 chr6:116381957 FRK 0.23 5.67 0.33 3.77e-8 Cholesterol, total;LDL cholesterol; CESC cis rs459571 0.834 rs379417 chr9:136890704 G/A cg13789015 chr9:136890014 NCRNA00094 0.56 7.96 0.44 5.15e-14 Platelet distribution width; CESC cis rs28498503 1.000 rs7238497 chr18:76660481 G/C cg00806245 chr18:76673096 NA -0.74 -6.15 -0.35 2.78e-9 Attention function in attention deficit hyperactive disorder; CESC trans rs208520 0.690 rs2126120 chr6:66742754 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 12.2 0.6 1.84e-27 Exhaled nitric oxide output; CESC cis rs9399137 0.507 rs7768278 chr6:135274957 T/C cg24558204 chr6:135376177 HBS1L 0.72 9.69 0.51 3.35e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg05234568 chr11:5960015 NA 0.54 7.43 0.42 1.49e-12 DNA methylation (variation); CESC cis rs17407555 0.518 rs16891234 chr4:9946163 A/G cg11266682 chr4:10021025 SLC2A9 -0.58 -7.2 -0.4 6.41e-12 Schizophrenia (age at onset); CESC cis rs1395 0.744 rs11679220 chr2:27476378 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 5.64 0.33 4.38e-8 Blood metabolite levels; CESC cis rs1707322 0.721 rs10890337 chr1:46124527 C/T cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3126085 0.935 rs2291770 chr1:152179792 G/C cg03465714 chr1:152285911 FLG -0.43 -5.16 -0.3 4.81e-7 Atopic dermatitis; CESC trans rs9391997 0.568 rs9328192 chr6:434364 C/T cg18341491 chr13:38174258 POSTN 0.32 6.14 0.35 2.99e-9 Chronic lymphocytic leukemia; CESC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg01570182 chr17:44337453 NA 0.66 8.94 0.48 6.86e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7267979 1.000 rs6076345 chr20:25381895 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.07 -0.74 4.03e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs2455799 0.613 rs13080234 chr3:15852492 C/T cg16303742 chr3:15540471 COLQ -0.37 -5.72 -0.33 2.8e-8 Mean platelet volume; CESC cis rs1691799 0.867 rs1168341 chr12:66759080 G/C cg16791601 chr12:66731901 HELB -0.79 -14.11 -0.65 4.25e-34 White blood cell count (basophil); CESC cis rs9389248 0.690 rs1028314 chr6:135255710 A/C cg24558204 chr6:135376177 HBS1L -0.63 -8.81 -0.48 1.65e-16 High light scatter reticulocyte percentage of red cells; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg09914029 chr8:117859175 RAD21 0.41 6.16 0.35 2.67e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1051424 0.642 rs115869798 chr17:57892829 T/A cg02344993 chr17:57696989 CLTC 0.68 8.37 0.46 3.31e-15 Obesity-related traits; CESC cis rs1728785 0.901 rs2862781 chr16:68639234 A/T cg02972257 chr16:68554789 NA -0.63 -7.01 -0.4 1.94e-11 Ulcerative colitis; CESC cis rs704 0.585 rs1007398 chr17:26665648 A/G cg10342447 chr17:26645325 TMEM97 -0.45 -6.29 -0.36 1.32e-9 Osteoprotegerin levels; CESC cis rs12579753 0.719 rs4384447 chr12:82268069 G/C cg21193143 chr12:82153300 PPFIA2 -0.34 -5.12 -0.3 5.77e-7 Resting heart rate; CESC cis rs1348850 0.526 rs59972556 chr2:178399561 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.67 6.13 0.35 3.22e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg04553112 chr3:125709451 NA -0.52 -5.47 -0.32 1.05e-7 Blood pressure (smoking interaction); CESC cis rs17125944 0.615 rs7146179 chr14:53298853 A/G cg00686598 chr14:53173677 PSMC6 -0.69 -6.02 -0.35 5.64e-9 Alzheimer's disease (late onset); CESC cis rs300703 0.872 rs300752 chr2:209292 A/G cg21211680 chr2:198530 NA 0.99 8.63 0.47 5.63e-16 Blood protein levels; CESC cis rs9831754 0.704 rs9882111 chr3:78470746 A/G cg06138941 chr3:78371609 NA -0.51 -6.44 -0.37 5.69e-10 Calcium levels; CESC cis rs12048904 0.619 rs10875347 chr1:101333737 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.64 7.49 0.42 1.03e-12 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13852536 chr9:32567045 NDUFB6 -0.66 -7.66 -0.43 3.58e-13 Gut microbiome composition (summer); CESC cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg24110177 chr3:50126178 RBM5 -0.5 -7.08 -0.4 1.26e-11 Intelligence (multi-trait analysis); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08496016 chr9:99181722 ZNF367 0.49 6.92 0.39 3.38e-11 Systemic lupus erythematosus; CESC cis rs2228479 0.681 rs11642428 chr16:89971909 A/T cg06558623 chr16:89946397 TCF25 0.52 5.07 0.3 7.57e-7 Skin colour saturation; CESC cis rs8072100 0.905 rs11651766 chr17:45574931 G/T cg08085267 chr17:45401833 C17orf57 -0.47 -6.22 -0.36 1.94e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25164226 chr22:47158357 TBC1D22A -0.44 -6.43 -0.37 5.94e-10 Gambling; CESC cis rs36051895 0.664 rs3780381 chr9:5114523 A/C cg02405213 chr9:5042618 JAK2 -0.53 -6.33 -0.36 1.06e-9 Pediatric autoimmune diseases; CESC cis rs727563 0.608 rs2076200 chr22:41985956 G/T cg03806693 chr22:41940476 POLR3H -1.16 -13.06 -0.63 1.99e-30 Crohn's disease;Inflammatory bowel disease; CESC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg18337363 chr3:52569053 NT5DC2 0.3 5.58 0.32 6.09e-8 Electroencephalogram traits; CESC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg24881330 chr22:46731750 TRMU 0.84 6.65 0.38 1.66e-10 LDL cholesterol;Cholesterol, total; CESC cis rs701145 0.529 rs355759 chr3:154008078 G/C cg16511985 chr3:153974050 SGEF 0.43 6.01 0.35 6.01e-9 Coronary artery disease; CESC cis rs12142240 0.698 rs72677592 chr1:46818288 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs6088580 0.634 rs11700221 chr20:32940320 T/C cg06115741 chr20:33292138 TP53INP2 -0.44 -5.54 -0.32 7.16e-8 Glomerular filtration rate (creatinine); CESC cis rs7208859 0.573 rs73267872 chr17:29067207 T/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.21 0.3 3.78e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Depression; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg01324437 chr2:98206175 ANKRD36B -0.47 -6.32 -0.36 1.07e-9 Thyroid stimulating hormone; CESC cis rs7998202 0.567 rs914019 chr13:113352911 A/G cg02820901 chr13:113351484 ATP11A 0.54 5.38 0.31 1.64e-7 Glycated hemoglobin levels; CESC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg04944784 chr2:26401820 FAM59B -0.8 -8.93 -0.48 7.17e-17 Gut microbiome composition (summer); CESC cis rs9549260 0.564 rs9577110 chr13:41271878 T/G cg21288729 chr13:41239152 FOXO1 0.6 7.72 0.43 2.36e-13 Red blood cell count; CESC cis rs8070740 0.947 rs3809842 chr17:5329199 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.54 6.53 0.37 3.32e-10 Menopause (age at onset); CESC cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg16278512 chr7:12443529 VWDE -0.5 -5.08 -0.3 7.3e-7 Coronary artery disease; CESC cis rs727505 0.954 rs2054586 chr7:124708414 C/T cg23710748 chr7:124431027 NA -0.39 -6.1 -0.35 3.77e-9 Lewy body disease; CESC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.42 -5.68 -0.33 3.59e-8 Bipolar disorder; CESC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.92 0.52 6.18e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11690935 0.921 rs7355523 chr2:172744421 T/C cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.21 -0.66 1.81e-34 Schizophrenia; CESC cis rs67311347 1.000 rs17078916 chr3:40445438 C/T cg24209194 chr3:40518798 ZNF619 0.51 6.24 0.36 1.75e-9 Renal cell carcinoma; CESC cis rs3126085 0.935 rs55942250 chr1:152251914 G/A cg03465714 chr1:152285911 FLG 0.5 5.7 0.33 3.11e-8 Atopic dermatitis; CESC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg18305652 chr10:134549665 INPP5A 0.49 6.95 0.39 2.89e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs57506017 0.565 rs2043539 chr7:12253880 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.21 0.3 3.77e-7 Neuroticism; CESC cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg26597838 chr10:835615 NA 0.95 10.15 0.53 1.19e-20 Eosinophil percentage of granulocytes; CESC cis rs2573652 1.000 rs12441080 chr15:100516968 A/G cg09918751 chr15:100517450 ADAMTS17 0.41 7.93 0.44 6.13e-14 Height; CESC cis rs9611565 0.546 rs2092274 chr22:42123737 A/G cg06481639 chr22:41940642 POLR3H 0.63 6.51 0.37 3.68e-10 Vitiligo; CESC cis rs6912958 0.781 rs9444512 chr6:88223397 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -7.43 -0.42 1.46e-12 Monocyte percentage of white cells; CESC cis rs10416265 0.527 rs7508599 chr19:33546512 A/T cg17764715 chr19:33622953 WDR88 0.61 8.35 0.46 3.88e-15 Bone properties (heel); CESC cis rs148387471 1 rs148387471 chr3:127057551 ATAG/A cg27326032 chr3:127006922 NA -0.45 -5.52 -0.32 8.19e-8 Interleukin-10 levels;Interleukin-13 levels; CESC cis rs72781680 1.000 rs72796316 chr2:24132272 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg04944784 chr2:26401820 FAM59B -0.63 -7.17 -0.4 7.54e-12 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16321116 chr14:59655311 DAAM1 -0.47 -6.12 -0.35 3.31e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2295499 0.754 rs35679952 chr4:2619709 G/A cg08330972 chr4:2403930 ZFYVE28 0.34 5.46 0.32 1.1e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs7618501 0.602 rs2624816 chr3:50117312 T/G cg21659725 chr3:3221576 CRBN -0.51 -7.03 -0.4 1.7e-11 Intelligence (multi-trait analysis); CESC cis rs72634258 0.945 rs12740409 chr1:8027830 A/C cg00042356 chr1:8021962 PARK7 0.92 8.2 0.45 1.01e-14 Inflammatory bowel disease; CESC cis rs3008870 1.000 rs2985795 chr1:67426223 A/G cg02640540 chr1:67518911 SLC35D1 0.52 5.59 0.33 5.5e-8 Lymphocyte percentage of white cells; CESC cis rs9788682 1.000 rs35212593 chr15:78831826 G/A cg06917634 chr15:78832804 PSMA4 -0.55 -6.49 -0.37 4.15e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs965469 1.000 rs6051716 chr20:3267736 C/T cg25506879 chr20:3388711 C20orf194 -0.58 -6.04 -0.35 5.18e-9 IFN-related cytopenia; CESC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.41 -0.32 1.44e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg17724175 chr1:150552817 MCL1 0.42 6.33 0.36 1.06e-9 Melanoma; CESC cis rs698833 0.828 rs6748528 chr2:44517752 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.44 5.5 0.32 8.85e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg03433033 chr1:76189801 ACADM 0.7 9.56 0.51 8.27e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9914988 0.943 rs2874253 chr17:27157863 A/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs116095464 0.558 rs7708515 chr5:234989 C/G cg22496380 chr5:211416 CCDC127 -0.75 -8.76 -0.47 2.36e-16 Breast cancer; CESC cis rs4253772 0.530 rs9615980 chr22:46791143 A/T cg00784671 chr22:46762841 CELSR1 -0.53 -5.07 -0.3 7.34e-7 LDL cholesterol;Cholesterol, total; CESC cis rs796364 0.512 rs1653290 chr2:201078165 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.53 5.37 0.31 1.74e-7 Schizophrenia; CESC cis rs13095912 1.000 rs13072061 chr3:185326023 G/T cg11274856 chr3:185301563 NA 0.36 5.81 0.34 1.83e-8 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11599612 chr6:151187337 MTHFD1L -0.62 -7.18 -0.4 7.12e-12 Gut microbiome composition (summer); CESC cis rs6582630 0.519 rs80226845 chr12:38528231 C/A cg13010199 chr12:38710504 ALG10B 0.46 5.96 0.34 7.85e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg18350739 chr11:68623251 NA -0.43 -6.73 -0.38 1.05e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs763014 0.898 rs8050792 chr16:656033 T/C cg07597022 chr16:675116 RAB40C -0.3 -5.09 -0.3 6.85e-7 Height; CESC cis rs8067545 0.611 rs2703788 chr17:20159686 T/C cg13482628 chr17:19912719 NA -0.43 -5.63 -0.33 4.59e-8 Schizophrenia; CESC cis rs7507204 0.767 rs62125962 chr19:3410852 A/G cg08380311 chr19:3435252 NFIC 0.63 6.72 0.38 1.1e-10 Height; CESC cis rs748404 0.660 rs2467741 chr15:43742626 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.61 0.42 4.92e-13 Lung cancer; CESC cis rs6032067 0.852 rs2868240 chr20:43874039 A/G cg10761708 chr20:43804764 PI3 -0.45 -5.41 -0.32 1.41e-7 Blood protein levels; CESC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg03806693 chr22:41940476 POLR3H -1.23 -16.62 -0.71 5.48e-43 Vitiligo; CESC cis rs2239547 0.657 rs3755803 chr3:52866157 C/G cg11645453 chr3:52864694 ITIH4 0.36 6.5 0.37 3.98e-10 Schizophrenia; CESC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg16049864 chr8:95962084 TP53INP1 -0.68 -12.13 -0.6 3.08e-27 Type 2 diabetes; CESC cis rs116988415 0.584 rs2269308 chr14:65244950 G/A cg25083366 chr14:65239357 SPTB 0.71 5.23 0.31 3.44e-7 Daytime sleep phenotypes; CESC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg08888203 chr3:10149979 C3orf24 0.53 6.72 0.38 1.11e-10 Alzheimer's disease; CESC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg17971929 chr21:40555470 PSMG1 -0.54 -6.93 -0.39 3.25e-11 Menarche (age at onset); CESC cis rs8072100 0.790 rs7222225 chr17:45693497 A/G cg08085267 chr17:45401833 C17orf57 0.47 5.8 0.34 1.89e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7077164 1.000 rs1227776 chr10:71580893 G/A cg20696214 chr10:71583771 COL13A1 -0.46 -6.56 -0.37 2.74e-10 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs7605827 0.930 rs4668912 chr2:15610882 C/T cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs7103648 0.669 rs10437655 chr11:47391948 G/A cg20307385 chr11:47447363 PSMC3 0.84 12.4 0.61 3.62e-28 Diastolic blood pressure;Systolic blood pressure; CESC cis rs2243480 0.803 rs55700941 chr7:65389800 T/A cg18252515 chr7:66147081 NA -1.18 -10.78 -0.55 1.08e-22 Diabetic kidney disease; CESC cis rs4547160 1.000 rs4547160 chr12:63503650 A/C cg26727693 chr12:63544175 AVPR1A 0.33 5.15 0.3 4.98e-7 Morning vs. evening chronotype; CESC cis rs631288 0.557 rs6697092 chr1:146659277 C/G cg25205988 chr1:146714368 CHD1L 1.04 6.66 0.38 1.58e-10 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs10504229 1.000 rs57378064 chr8:58169844 C/G cg24829409 chr8:58192753 C8orf71 -0.62 -8.5 -0.46 1.41e-15 Developmental language disorder (linguistic errors); CESC cis rs8112211 1.000 rs12611255 chr19:38815483 T/C cg14299480 chr19:38876666 GGN -0.42 -5.71 -0.33 2.98e-8 Blood protein levels; CESC cis rs1801251 1.000 rs7587309 chr2:233705702 G/T cg25237894 chr2:233734115 C2orf82 -0.46 -8.15 -0.45 1.43e-14 Coronary artery disease; CESC cis rs703842 0.642 rs10876994 chr12:58064737 A/C cg04478727 chr12:58166393 METTL1;FAM119B 0.49 5.29 0.31 2.56e-7 Multiple sclerosis; CESC trans rs9467711 0.523 rs9379853 chr6:26357635 A/G cg06606381 chr12:133084897 FBRSL1 -0.76 -6.87 -0.39 4.66e-11 Autism spectrum disorder or schizophrenia; CESC cis rs614367 1.000 rs614367 chr11:69328764 A/G cg08353955 chr11:69289746 NA 0.49 5.39 0.31 1.58e-7 Breast cancer;Breast cancer (early onset); CESC cis rs12819124 0.502 rs10875718 chr12:48411102 G/T cg24011408 chr12:48396354 COL2A1 0.53 8.09 0.45 2.16e-14 Glycated hemoglobin levels; CESC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg04553112 chr3:125709451 NA -0.51 -5.59 -0.33 5.51e-8 Blood pressure (smoking interaction); CESC cis rs926938 0.520 rs6660624 chr1:115272163 G/A cg12756093 chr1:115239321 AMPD1 -0.52 -6.36 -0.36 8.77e-10 Autism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14929913 chr10:1147979 WDR37 -0.65 -7.23 -0.41 5.21e-12 Gut microbiome composition (summer); CESC cis rs6120849 0.754 rs6088682 chr20:33615702 A/C cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs728616 0.558 rs7097080 chr10:82166700 A/G cg05935833 chr10:81318306 SFTPA2 -0.37 -5.14 -0.3 5.39e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs4950322 0.634 rs7542951 chr1:146812058 C/T cg22381352 chr1:146742008 CHD1L -0.47 -5.05 -0.3 8.2e-7 Protein quantitative trait loci; CESC cis rs4604732 0.631 rs74154673 chr1:247625629 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.26 0.31 3e-7 Bipolar disorder; CESC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg26839252 chr6:160211577 TCP1;MRPL18 0.49 6.14 0.35 2.95e-9 Age-related macular degeneration (geographic atrophy); CESC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg22903471 chr2:27725779 GCKR -0.55 -7.77 -0.43 1.69e-13 Menopause (age at onset); CESC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg00149659 chr3:10157352 C3orf10 0.71 8.29 0.45 5.85e-15 Alzheimer's disease; CESC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs921968 0.541 rs1863704 chr2:219562675 C/T cg02176678 chr2:219576539 TTLL4 -0.52 -8.75 -0.47 2.57e-16 Mean corpuscular hemoglobin concentration; CESC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg07648498 chr16:89883185 FANCA 0.43 5.31 0.31 2.38e-7 Vitiligo; CESC cis rs9549260 0.534 rs4943809 chr13:41297404 T/A cg21288729 chr13:41239152 FOXO1 0.57 5.15 0.3 5.1e-7 Red blood cell count; CESC cis rs4268898 0.965 rs4665673 chr2:24459737 A/T cg20701182 chr2:24300061 SF3B14 -0.42 -5.15 -0.3 5.21e-7 Asthma; CESC cis rs12681288 0.550 rs4410933 chr8:959581 A/G cg15309053 chr8:964076 NA 0.51 8.94 0.48 6.89e-17 Schizophrenia; CESC cis rs4835473 0.897 rs7682128 chr4:144630103 A/G cg25736465 chr4:144833511 NA 0.4 6.17 0.35 2.59e-9 Immature fraction of reticulocytes; CESC cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.39 -6.53 -0.37 3.3e-10 Hemoglobin concentration; CESC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg04287289 chr16:89883240 FANCA 0.89 15.03 0.68 2.34e-37 Vitiligo; CESC cis rs9362426 1.000 rs406900 chr6:88085447 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.47 5.93 0.34 9.21e-9 Depressive episodes in bipolar disorder; CESC trans rs11072089 0.892 rs11072093 chr15:69669978 C/T cg10917153 chr15:42448786 PLA2G4F 0.42 6.05 0.35 4.79e-9 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1691799 0.899 rs1060724 chr12:66740444 T/C cg16791601 chr12:66731901 HELB -0.75 -12.95 -0.62 4.83e-30 White blood cell count (basophil); CESC cis rs4689388 0.926 rs6446480 chr4:6295565 C/T cg25554036 chr4:6271136 WFS1 0.5 8.13 0.45 1.66e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs35110281 0.744 rs8131027 chr21:45104908 G/C cg04455712 chr21:45112962 RRP1B 0.46 7.28 0.41 3.69e-12 Mean corpuscular volume; CESC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg19468946 chr17:37922297 IKZF3 0.4 5.27 0.31 2.83e-7 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20471045 chr19:49568214 NTF4 0.61 7.01 0.4 2.01e-11 Gut microbiome composition (summer); CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.46 -6.14 -0.35 2.93e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg17372223 chr3:52568218 NT5DC2 -0.41 -6.02 -0.35 5.76e-9 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21484680 chr2:27593328 EIF2B4;SNX17 -0.5 -6.6 -0.38 2.19e-10 Fibrinogen levels; CESC cis rs7845219 0.544 rs4735332 chr8:95923660 C/T cg09323728 chr8:95962352 TP53INP1 -0.34 -6.77 -0.38 8.44e-11 Type 2 diabetes; CESC cis rs2806561 0.765 rs682766 chr1:23516397 C/G cg12483005 chr1:23474871 LUZP1 0.38 6.0 0.35 6.44e-9 Height; CESC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg03188948 chr7:1209495 NA 0.72 6.95 0.39 2.83e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2191566 0.664 rs62115482 chr19:44554083 C/A cg20607764 chr19:44506953 ZNF230 -0.44 -5.64 -0.33 4.34e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs8141529 0.732 rs5762784 chr22:29171298 C/T cg02153584 chr22:29168773 CCDC117 0.7 10.05 0.53 2.43e-20 Lymphocyte counts; CESC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg11644478 chr21:40555479 PSMG1 0.95 14.26 0.66 1.25e-34 Cognitive function; CESC cis rs7662987 0.517 rs1311617 chr4:100012425 T/G cg12011299 chr4:100065546 ADH4 0.61 6.71 0.38 1.17e-10 Smoking initiation; CESC cis rs9715521 0.589 rs11726451 chr4:59852381 A/C cg11281224 chr4:60001000 NA -0.4 -5.35 -0.31 1.9e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2735413 0.802 rs5008070 chr16:78096404 T/C cg04733911 chr16:78082701 NA 0.47 7.32 0.41 3.01e-12 Systolic blood pressure (alcohol consumption interaction); CESC cis rs59918340 0.764 rs4961338 chr8:142230192 C/T cg16341495 chr8:142228727 SLC45A4 0.45 5.5 0.32 8.72e-8 Immature fraction of reticulocytes; CESC cis rs7178572 0.568 rs12907847 chr15:77493174 C/T cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg15704280 chr7:45808275 SEPT13 0.88 11.18 0.57 5.18e-24 Height; CESC cis rs35110281 0.565 rs7278003 chr21:44966069 T/C cg21573476 chr21:45109991 RRP1B -0.4 -5.44 -0.32 1.2e-7 Mean corpuscular volume; CESC cis rs2836633 0.895 rs2836598 chr21:40024758 C/G cg12884169 chr21:40033163 ERG 0.35 5.44 0.32 1.22e-7 Coronary artery disease; CESC cis rs2625529 0.730 rs2957368 chr15:72329906 C/T cg16672083 chr15:72433130 SENP8 -0.43 -6.6 -0.38 2.24e-10 Red blood cell count; CESC cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10887741 0.690 rs12772633 chr10:89442492 G/A cg13926569 chr10:89418898 PAPSS2 0.36 5.43 0.32 1.29e-7 Exercise (leisure time); CESC cis rs1008375 1.000 rs2058337 chr4:17678649 C/T cg02297831 chr4:17616191 MED28 0.45 5.84 0.34 1.51e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.74 9.21 0.49 1.03e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs559928 0.606 rs78038516 chr11:63978067 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.62 5.61 0.33 5.1e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs2832191 0.791 rs57721945 chr21:30498744 T/C cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.5e-20 Dental caries; CESC cis rs9549367 0.789 rs12584813 chr13:113895443 C/G cg18105134 chr13:113819100 PROZ -0.67 -8.06 -0.44 2.71e-14 Platelet distribution width; CESC cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg02297831 chr4:17616191 MED28 0.6 7.75 0.43 1.93e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs959260 1.000 rs2117562 chr17:73369000 C/T cg12999837 chr17:73267436 MIF4GD -0.47 -5.45 -0.32 1.17e-7 Systemic lupus erythematosus; CESC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg02475777 chr4:1388615 CRIPAK -0.47 -6.15 -0.35 2.9e-9 Obesity-related traits; CESC trans rs11098499 0.863 rs10030660 chr4:120436704 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.5 0.5 1.34e-18 Corneal astigmatism; CESC cis rs1018836 0.851 rs2023624 chr8:91618874 T/C cg16814680 chr8:91681699 NA -0.77 -11.99 -0.59 9.6e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg11859384 chr17:80120422 CCDC57 0.38 5.15 0.3 5.1e-7 Life satisfaction; CESC cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg03433033 chr1:76189801 ACADM -0.67 -7.91 -0.44 7.05e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg12311346 chr5:56204834 C5orf35 -0.5 -6.2 -0.36 2.11e-9 Coronary artery disease; CESC cis rs6582630 0.638 rs35864536 chr12:38472255 T/A cg26384229 chr12:38710491 ALG10B -0.42 -5.52 -0.32 8.27e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18851521 chr18:268131 THOC1 0.59 7.21 0.4 5.69e-12 Gut microbiome composition (summer); CESC cis rs56399783 0.901 rs17132741 chr7:2868997 C/T cg19731401 chr7:2775893 GNA12 -0.59 -5.52 -0.32 7.9e-8 Childhood ear infection; CESC cis rs1499972 0.941 rs62264816 chr3:117666232 C/G cg07612923 chr3:117604196 NA 0.89 7.41 0.41 1.71e-12 Schizophrenia; CESC cis rs71403859 0.502 rs34380814 chr16:71488175 C/T cg08717414 chr16:71523259 ZNF19 -0.78 -8.36 -0.46 3.54e-15 Post bronchodilator FEV1; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14094447 chr9:74383399 TMEM2 -0.46 -6.19 -0.36 2.31e-9 Fibrinogen levels; CESC cis rs3008870 0.785 rs10889651 chr1:67463513 A/T cg08660285 chr1:67390436 MIER1;WDR78 -0.65 -8.58 -0.47 7.92e-16 Lymphocyte percentage of white cells; CESC cis rs2637266 0.655 rs10824436 chr10:78457848 T/C cg18941641 chr10:78392320 NA 0.39 6.88 0.39 4.26e-11 Pulmonary function; CESC cis rs9976767 0.608 rs11909987 chr21:43822402 C/A cg23042151 chr21:43824109 UBASH3A -0.32 -6.01 -0.35 5.98e-9 Type 1 diabetes; CESC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg17747265 chr1:1875780 NA -0.58 -9.33 -0.5 4.41e-18 Body mass index; CESC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg06873352 chr17:61820015 STRADA 0.47 6.81 0.39 6.42e-11 Height; CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg04775059 chr7:64541387 NA 0.44 5.52 0.32 8.23e-8 Calcium levels; CESC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg20151795 chr6:28129481 ZNF389 0.43 5.36 0.31 1.85e-7 Parkinson's disease; CESC cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs826838 0.935 rs11183940 chr12:38851642 A/G cg26384229 chr12:38710491 ALG10B 0.83 14.57 0.67 1.05e-35 Heart rate; CESC cis rs9457247 0.765 rs3752520 chr6:167436159 T/C cg07741184 chr6:167504864 NA 0.35 6.29 0.36 1.31e-9 Crohn's disease; CESC cis rs2625529 0.652 rs2899775 chr15:72268354 C/T cg16672083 chr15:72433130 SENP8 0.46 6.81 0.39 6.7e-11 Red blood cell count; CESC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg22800045 chr5:56110881 MAP3K1 -0.59 -7.41 -0.41 1.65e-12 Initial pursuit acceleration; CESC cis rs2625529 0.526 rs10851850 chr15:72486509 A/G cg16672083 chr15:72433130 SENP8 0.41 6.3 0.36 1.23e-9 Red blood cell count; CESC cis rs12950390 0.893 rs72831644 chr17:45824391 T/C cg00777063 chr17:45855553 NA -0.42 -6.16 -0.35 2.64e-9 IgG glycosylation; CESC cis rs3981351 0.797 rs61866462 chr10:115464690 C/T cg24846397 chr10:115438155 CASP7 -0.34 -5.09 -0.3 6.93e-7 Obesity-related traits; CESC cis rs75064307 0.834 rs4588370 chr3:108114050 G/A cg03329597 chr3:108125523 MYH15 0.51 5.77 0.33 2.17e-8 Intelligence (multi-trait analysis); CESC cis rs11122272 0.735 rs2808603 chr1:231537738 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.08 0.35 4.07e-9 Hemoglobin concentration; CESC cis rs11958404 1.000 rs72816523 chr5:157403168 G/C cg05962755 chr5:157440814 NA 0.58 6.39 0.37 7.58e-10 IgG glycosylation; CESC cis rs9300255 0.663 rs7953929 chr12:123758235 C/G cg00376283 chr12:123451042 ABCB9 0.62 6.82 0.39 6.1e-11 Neutrophil percentage of white cells; CESC cis rs34330 0.562 rs17212236 chr12:12855483 G/C cg04607235 chr12:12878440 APOLD1 -0.84 -9.03 -0.49 3.59e-17 Systemic lupus erythematosus; CESC cis rs11098499 0.754 rs10212775 chr4:120239244 G/C cg09307838 chr4:120376055 NA 0.79 10.77 0.55 1.17e-22 Corneal astigmatism; CESC cis rs62408225 1.000 rs55771973 chr6:90981319 T/G cg06866423 chr6:90926672 BACH2 0.43 5.15 0.3 5.08e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2742234 0.541 rs10899786 chr10:43744583 G/A cg07801480 chr10:43725741 RASGEF1A -0.41 -5.22 -0.31 3.61e-7 Hirschsprung disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17711541 chr6:26124704 HIST1H2AC;HIST1H2BC -0.56 -6.22 -0.36 1.97e-9 Gut microbiome composition (summer); CESC cis rs8060686 0.641 rs78537727 chr16:68120606 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 4.92e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg02935154 chr7:12443704 VWDE -0.58 -6.25 -0.36 1.67e-9 Coronary artery disease; CESC cis rs1881797 1.000 rs68059491 chr1:247683070 C/T cg05639522 chr1:247681581 NA 0.5 6.36 0.36 8.64e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs2637266 0.875 rs2395409 chr10:78381004 A/G cg18941641 chr10:78392320 NA 0.4 7.49 0.42 1.03e-12 Pulmonary function; CESC cis rs919433 0.783 rs788014 chr2:198228997 G/A cg10820045 chr2:198174542 NA 0.4 5.83 0.34 1.57e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs733175 0.855 rs10018666 chr4:10004805 C/T cg00071950 chr4:10020882 SLC2A9 0.57 6.75 0.38 9.47e-11 Psychosis and Alzheimer's disease; CESC cis rs9621305 0.502 rs2295242 chr22:31957752 G/A cg25791279 chr22:32026902 PISD 0.55 5.55 0.32 6.84e-8 Intelligence; CESC cis rs11155671 0.530 rs9371223 chr6:150214806 T/C cg09699651 chr6:150184138 LRP11 0.54 7.44 0.42 1.38e-12 Testicular germ cell tumor; CESC cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg22875332 chr1:76189707 ACADM 0.59 5.73 0.33 2.74e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7394190 0.748 rs12572278 chr10:75504513 C/A cg07699608 chr10:75541558 CHCHD1 0.64 5.21 0.3 3.8e-7 Incident atrial fibrillation; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21518056 chr19:33183187 NUDT19 -0.57 -7.05 -0.4 1.54e-11 Ulcerative colitis; CESC cis rs365132 1.000 rs2055619 chr5:176415964 A/G cg16309518 chr5:176445507 NA -0.37 -5.35 -0.31 1.9e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs1559088 0.573 rs1270591 chr19:33622942 C/T cg03563238 chr19:33554763 RHPN2 0.29 5.28 0.31 2.67e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs870825 0.616 rs55685500 chr4:185614810 G/A cg04058563 chr4:185651563 MLF1IP 0.64 6.48 0.37 4.51e-10 Blood protein levels; CESC cis rs8067354 0.645 rs9901606 chr17:57811407 A/C cg02344993 chr17:57696989 CLTC 0.68 8.08 0.44 2.34e-14 Hemoglobin concentration; CESC cis rs11098499 0.697 rs4373140 chr4:120307698 A/G cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23868848 chr8:128806661 PVT1 0.56 6.01 0.35 5.97e-9 Gut microbiome composition (summer); CESC cis rs7301826 0.651 rs10773824 chr12:131298851 G/A cg11011512 chr12:131303247 STX2 0.46 5.57 0.32 6.37e-8 Plasma plasminogen activator levels; CESC cis rs4148883 0.651 rs4147547 chr4:100127311 G/T cg13256891 chr4:100009986 ADH5 0.5 6.47 0.37 4.68e-10 Alcohol dependence; CESC cis rs4642101 0.662 rs9874893 chr3:12833079 C/G cg24848339 chr3:12840334 CAND2 0.38 5.75 0.33 2.52e-8 QRS complex (12-leadsum); CESC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg12419862 chr22:24373484 LOC391322 0.61 8.22 0.45 9.07e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10832963 1.000 rs10832956 chr11:18645668 A/G cg09201001 chr11:18656081 SPTY2D1 0.83 12.89 0.62 7.9e-30 Breast cancer; CESC cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg24531977 chr5:56204891 C5orf35 0.7 9.44 0.5 2.05e-18 Initial pursuit acceleration; CESC cis rs3733585 0.648 rs28513781 chr4:9959334 G/C cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2066819 1.000 rs41423244 chr12:56693520 A/C cg26714650 chr12:56694279 CS 1.52 10.3 0.53 3.81e-21 Psoriasis vulgaris; CESC cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.679 rs1596142 chr8:58032406 G/A cg22535103 chr8:58192502 C8orf71 -0.61 -6.86 -0.39 4.87e-11 Developmental language disorder (linguistic errors); CESC cis rs6570726 0.791 rs441290 chr6:145883183 A/G cg23711669 chr6:146136114 FBXO30 0.87 12.82 0.62 1.32e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg06808227 chr14:105710500 BRF1 -0.58 -7.07 -0.4 1.35e-11 Mean platelet volume;Platelet distribution width; CESC cis rs9549367 0.826 rs1885688 chr13:113894236 G/T cg00898013 chr13:113819073 PROZ -0.53 -7.52 -0.42 8.66e-13 Platelet distribution width; CESC trans rs4942242 0.663 rs1390371 chr13:44211727 A/G cg19169023 chr15:41853346 TYRO3 0.58 7.38 0.41 1.99e-12 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4780401 0.609 rs4781143 chr16:11809721 T/G cg01061890 chr16:11836724 TXNDC11 -0.56 -7.59 -0.42 5.37e-13 Rheumatoid arthritis; CESC cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.81 7.71 0.43 2.49e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg06221963 chr1:154839813 KCNN3 -0.66 -11.44 -0.58 6.67e-25 Prostate cancer; CESC cis rs807669 0.903 rs2800974 chr22:19168087 C/T cg02655711 chr22:19163373 SLC25A1 0.96 14.87 0.67 9.02e-37 Metabolite levels; CESC trans rs11098499 0.954 rs71614438 chr4:120371252 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg06634786 chr22:41940651 POLR3H -0.64 -6.69 -0.38 1.3e-10 Vitiligo; CESC cis rs78889164 1.000 rs60463402 chr19:33855841 C/T cg02272751 chr19:33882848 PEPD -0.51 -6.62 -0.38 2.02e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17101226 chr11:64794859 SNX15 -0.47 -6.26 -0.36 1.53e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg19163074 chr7:65112434 INTS4L2 -0.41 -5.11 -0.3 6.29e-7 Aortic root size; CESC cis rs8028182 0.636 rs8023815 chr15:75814704 G/A cg20655648 chr15:75932815 IMP3 0.48 5.9 0.34 1.08e-8 Sudden cardiac arrest; CESC trans rs7246657 0.891 rs7257495 chr19:37823876 C/G cg24637308 chr11:6592297 DNHD1 0.53 6.24 0.36 1.74e-9 Coronary artery calcification; CESC cis rs10256972 0.900 rs4388364 chr7:1033045 T/G cg23978390 chr7:1156363 C7orf50 0.44 5.81 0.34 1.77e-8 Longevity;Endometriosis; CESC cis rs826838 0.967 rs826870 chr12:39120250 G/A cg26384229 chr12:38710491 ALG10B -0.67 -11.02 -0.56 1.72e-23 Heart rate; CESC cis rs763014 0.931 rs59476302 chr16:629006 C/T cg00908189 chr16:619842 PIGQ 0.67 9.39 0.5 2.78e-18 Height; CESC cis rs12478296 1.000 rs55814222 chr2:243041166 C/T cg06360820 chr2:242988706 NA -0.66 -7.52 -0.42 8.51e-13 Obesity-related traits; CESC cis rs9815354 0.767 rs17281609 chr3:41833432 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs17057718 1.000 rs12486855 chr3:57125864 A/G cg04869497 chr17:20059225 CYTSB -0.56 -5.99 -0.35 6.63e-9 Cerebrospinal fluid biomarker levels; CESC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg00149659 chr3:10157352 C3orf10 0.73 8.89 0.48 9.97e-17 Alzheimer's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24489237 chr1:164529170 PBX1 -0.42 -6.23 -0.36 1.78e-9 Gut microbiota (bacterial taxa); CESC cis rs9811920 0.609 rs7636447 chr3:99612677 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.55 -0.37 2.95e-10 Bipolar disorder; CESC cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg08999081 chr20:33150536 PIGU -0.38 -5.33 -0.31 2.05e-7 Height; CESC cis rs2243480 0.708 rs781141 chr7:65438553 A/G cg18252515 chr7:66147081 NA -1.06 -10.21 -0.53 7.51e-21 Diabetic kidney disease; CESC cis rs6964587 1.000 rs13231238 chr7:91653851 T/G cg17063962 chr7:91808500 NA 0.58 8.02 0.44 3.36e-14 Breast cancer; CESC cis rs57786342 0.539 rs4902652 chr14:69280309 A/G cg03189333 chr14:69283534 NA 0.45 5.17 0.3 4.53e-7 Macrophage inflammatory protein 1a levels; CESC cis rs367615 0.552 rs3828603 chr5:108712068 G/C cg17395555 chr5:108820864 NA -0.45 -7.5 -0.42 9.87e-13 Colorectal cancer (SNP x SNP interaction); CESC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.03 -0.35 5.5e-9 Parkinson's disease; CESC cis rs7208859 0.623 rs9894709 chr17:29078454 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.92 -0.52 6.14e-20 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.954 rs10006706 chr4:120409152 A/G cg09160332 chr4:120329925 NA -0.39 -5.18 -0.3 4.35e-7 Corneal astigmatism; CESC cis rs7786877 0.582 rs2075674 chr7:100225031 G/A cg20848291 chr7:100343083 ZAN -0.67 -7.01 -0.4 1.96e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg01448562 chr3:133502909 NA -0.43 -5.94 -0.34 8.79e-9 Iron status biomarkers; CESC cis rs4713675 0.584 rs3818527 chr6:33661035 A/G cg14003231 chr6:33640908 ITPR3 -0.32 -5.55 -0.32 6.98e-8 Plateletcrit; CESC trans rs116095464 0.558 rs56081398 chr5:247318 C/T cg00938859 chr5:1591904 SDHAP3 0.71 6.69 0.38 1.29e-10 Breast cancer; CESC cis rs17384381 0.953 rs12120551 chr1:85810903 T/C cg16011679 chr1:85725395 C1orf52 0.8 8.2 0.45 1.03e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg23161317 chr6:28129485 ZNF389 0.49 5.88 0.34 1.26e-8 Parkinson's disease; CESC cis rs7635838 0.892 rs2880897 chr3:11494544 A/G cg00170343 chr3:11313890 ATG7 0.46 6.18 0.35 2.46e-9 HDL cholesterol; CESC cis rs722599 0.683 rs7142898 chr14:75254310 A/T cg11812906 chr14:75593930 NEK9 0.45 5.45 0.32 1.17e-7 IgG glycosylation; CESC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.55 -0.32 7.08e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18265147 chr1:9256671 NA 0.59 6.2 0.36 2.17e-9 Gut microbiome composition (summer); CESC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.7 6.19 0.36 2.33e-9 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07967114 chr12:94915694 NA -0.56 -6.63 -0.38 1.91e-10 Gut microbiome composition (summer); CESC cis rs595982 0.559 rs17272680 chr19:49364511 A/G cg15549821 chr19:49342101 PLEKHA4 0.68 8.1 0.45 2.04e-14 Red cell distribution width; CESC cis rs8002861 0.875 rs12869697 chr13:44439169 T/C cg14210620 chr13:44453864 C13orf31;CCDC122 -0.45 -5.62 -0.33 4.93e-8 Leprosy; CESC cis rs688020 1.000 rs673500 chr7:4229445 C/G cg02004499 chr7:4244250 SDK1 -0.39 -5.43 -0.32 1.24e-7 Liver fibrosis in pediatric non-alcoholic fatty acid liver disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04441191 chr3:48130393 MAP4 -0.46 -6.22 -0.36 1.91e-9 Fibrinogen levels; CESC cis rs2734839 0.964 rs2734838 chr11:113286501 A/G cg14159747 chr11:113255604 NA 0.29 5.13 0.3 5.48e-7 Information processing speed; CESC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg21770322 chr7:97807741 LMTK2 0.58 8.5 0.46 1.36e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.3 0.36 1.21e-9 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16754643 chr12:133518353 ZNF605 0.6 8.03 0.44 3.1e-14 Fibrinogen levels; CESC cis rs6582630 0.555 rs6582503 chr12:38557886 A/C cg26384229 chr12:38710491 ALG10B 0.76 11.63 0.58 1.62e-25 Drug-induced liver injury (flucloxacillin); CESC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg14829155 chr15:31115871 NA -0.72 -9.67 -0.51 3.76e-19 Huntington's disease progression; CESC cis rs3105593 0.605 rs3131562 chr15:50772479 C/T cg08437265 chr15:50716283 USP8 0.48 6.34 0.36 9.58e-10 QT interval; CESC cis rs72945132 0.678 rs12786421 chr11:70235314 G/C cg00319359 chr11:70116639 PPFIA1 0.71 6.66 0.38 1.6e-10 Coronary artery disease; CESC cis rs7568498 0.517 rs197261 chr2:161904823 A/G cg08807892 chr2:162101083 NA -0.54 -5.79 -0.33 2.03e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg09664259 chr3:156544070 LEKR1 0.49 6.05 0.35 4.82e-9 Myopia (pathological); CESC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg04414720 chr1:150670196 GOLPH3L 0.45 5.96 0.34 8.13e-9 Melanoma; CESC cis rs1559088 0.803 rs10405770 chr19:33616549 C/T cg17764715 chr19:33622953 WDR88 0.45 5.85 0.34 1.45e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6460942 0.514 rs118124486 chr7:12470381 T/G cg02935154 chr7:12443704 VWDE -0.5 -7.52 -0.42 8.35e-13 Coronary artery disease; CESC cis rs11642862 0.901 rs76345698 chr16:30946165 G/A cg02466173 chr16:30829666 NA -0.57 -5.21 -0.3 3.81e-7 Tonsillectomy; CESC cis rs6541297 0.938 rs1555289 chr1:230292499 C/T cg05784532 chr1:230284198 GALNT2 -0.49 -5.51 -0.32 8.4e-8 Coronary artery disease; CESC cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg05340658 chr4:99064831 C4orf37 0.66 9.01 0.48 4.1e-17 Colonoscopy-negative controls vs population controls; CESC cis rs1050631 1.000 rs3110564 chr18:33701589 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 -0.43 -5.74 -0.33 2.54e-8 Esophageal squamous cell cancer (length of survival); CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg16010370 chr3:53290200 TKT 0.43 5.99 0.35 6.67e-9 Retinol levels; CESC cis rs4979906 1.000 rs4979907 chr10:79451969 C/A cg07817648 chr10:79422355 NA -0.59 -6.29 -0.36 1.28e-9 Mortality in heart failure; CESC cis rs863345 0.604 rs10908651 chr1:158451272 A/C cg12129480 chr1:158549410 OR10X1 0.34 6.79 0.38 7.4e-11 Pneumococcal bacteremia; CESC cis rs11098499 0.909 rs79026312 chr4:120440677 C/A cg09307838 chr4:120376055 NA 0.92 12.5 0.61 1.73e-28 Corneal astigmatism; CESC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg22143856 chr6:28129313 ZNF389 -0.42 -5.33 -0.31 2.09e-7 Depression; CESC cis rs55871839 0.708 rs12115074 chr8:59817473 C/T cg07426533 chr8:59803705 TOX -0.41 -5.89 -0.34 1.19e-8 Pneumonia; CESC cis rs6987853 0.712 rs56220385 chr8:42428862 A/T cg09913449 chr8:42400586 C8orf40 0.47 7.85 0.43 1.04e-13 Mean corpuscular hemoglobin concentration; CESC cis rs6540559 0.546 rs75308488 chr1:210030639 T/C cg22029157 chr1:209979665 IRF6 0.72 7.12 0.4 1.04e-11 Cleft lip with or without cleft palate; CESC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.26 -0.36 1.55e-9 Menopause (age at onset); CESC cis rs7107174 1.000 rs10899470 chr11:78020052 C/T cg02023728 chr11:77925099 USP35 0.48 6.27 0.36 1.46e-9 Testicular germ cell tumor; CESC cis rs9487051 0.676 rs7753705 chr6:109593302 A/C cg12927641 chr6:109611667 NA -0.37 -5.56 -0.32 6.55e-8 Reticulocyte fraction of red cells; CESC cis rs7202877 0.706 rs1540 chr16:75481185 G/C cg04384234 chr16:75411784 CFDP1 0.52 5.84 0.34 1.56e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs1008375 1.000 rs10939749 chr4:17692319 A/C cg02297831 chr4:17616191 MED28 0.47 5.7 0.33 3.11e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7264396 0.563 rs6060592 chr20:34352414 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.68 7.4 0.41 1.83e-12 Total cholesterol levels; CESC cis rs965469 1.000 rs6051705 chr20:3253143 G/A cg25506879 chr20:3388711 C20orf194 -0.58 -6.24 -0.36 1.7e-9 IFN-related cytopenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05874913 chr2:160569340 MARCH7 0.6 6.53 0.37 3.27e-10 Gut microbiome composition (summer); CESC cis rs9549260 0.753 rs9549243 chr13:41217205 G/A cg21288729 chr13:41239152 FOXO1 0.58 5.86 0.34 1.38e-8 Red blood cell count; CESC cis rs6088580 0.524 rs6088564 chr20:33249444 A/G cg08999081 chr20:33150536 PIGU -0.46 -6.42 -0.37 6.23e-10 Glomerular filtration rate (creatinine); CESC cis rs4919087 0.926 rs953097 chr10:98981914 T/C cg25902810 chr10:99078978 FRAT1 0.71 10.32 0.54 3.25e-21 Monocyte count; CESC cis rs76878669 0.561 rs6591217 chr11:66174653 G/A cg18002602 chr11:66138449 SLC29A2 -0.36 -5.82 -0.34 1.7e-8 Educational attainment (years of education); CESC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg25036284 chr2:26402008 FAM59B -0.57 -6.57 -0.37 2.61e-10 Gut microbiome composition (summer); CESC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg19592336 chr6:28129416 ZNF389 0.54 6.94 0.39 3e-11 Parkinson's disease; CESC cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -9.62 -0.51 5.71e-19 Extrinsic epigenetic age acceleration; CESC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg21770322 chr7:97807741 LMTK2 0.54 8.13 0.45 1.67e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs67478160 0.619 rs11160759 chr14:104231542 C/T cg01849466 chr14:104193079 ZFYVE21 -0.5 -6.89 -0.39 4.13e-11 Schizophrenia; CESC trans rs1728785 0.901 rs1183956 chr16:68606726 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.93 0.44 6e-14 Ulcerative colitis; CESC cis rs1448094 0.842 rs10779231 chr12:86462237 T/C cg02569458 chr12:86230093 RASSF9 -0.35 -5.24 -0.31 3.23e-7 Major depressive disorder; CESC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg19346786 chr7:2764209 NA -0.46 -6.56 -0.37 2.82e-10 Height; CESC cis rs2243480 1.000 rs6949812 chr7:65387101 G/A cg12463550 chr7:65579703 CRCP 0.7 5.58 0.32 5.94e-8 Diabetic kidney disease; CESC trans rs561341 1.000 rs473356 chr17:30321762 G/C cg20587970 chr11:113659929 NA -1.44 -18.71 -0.75 2.25e-50 Hip circumference adjusted for BMI; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04284535 chr17:41624145 ETV4 0.39 6.17 0.35 2.58e-9 Gambling; CESC cis rs3733585 0.673 rs4292332 chr4:9953830 C/A cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10463316 0.963 rs4958450 chr5:150739932 A/C cg03212797 chr5:150827313 SLC36A1 -0.45 -5.29 -0.31 2.57e-7 Metabolite levels (Pyroglutamine); CESC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.62 0.33 4.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg22535103 chr8:58192502 C8orf71 -1.07 -13.57 -0.64 3.2e-32 Developmental language disorder (linguistic errors); CESC cis rs12410462 0.681 rs4131980 chr1:227572123 A/G cg23173402 chr1:227635558 NA 0.68 5.72 0.33 2.88e-8 Major depressive disorder; CESC trans rs4824093 0.610 rs73443906 chr22:50274293 A/G cg09872104 chr7:134855509 C7orf49 -0.97 -6.92 -0.39 3.45e-11 Amyotrophic lateral sclerosis (sporadic); CESC cis rs910316 0.763 rs1548807 chr14:75479582 T/G cg16144293 chr14:75469539 EIF2B2 -0.39 -5.24 -0.31 3.34e-7 Height; CESC cis rs826838 1.000 rs11183941 chr12:38851692 G/C cg13010199 chr12:38710504 ALG10B 0.6 8.53 0.46 1.18e-15 Heart rate; CESC cis rs2228479 0.541 rs12918575 chr16:89811151 A/G cg04013166 chr16:89971882 TCF25 0.72 7.87 0.44 9.3e-14 Skin colour saturation; CESC cis rs4423214 1.000 rs12806844 chr11:71170770 G/A cg05163923 chr11:71159392 DHCR7 0.78 10.34 0.54 2.91e-21 Vitamin D levels; CESC trans rs4906172 0.716 rs8019874 chr14:102521309 T/C cg17920195 chr4:129149383 NA 0.32 6.24 0.36 1.76e-9 Menopause (age at onset); CESC cis rs7072216 0.770 rs1737 chr10:100176366 T/C cg26618903 chr10:100175079 PYROXD2 -0.33 -5.11 -0.3 6.12e-7 Metabolite levels; CESC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg05340658 chr4:99064831 C4orf37 0.81 12.65 0.61 5.22e-29 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16755598 chr14:50100815 C14orf104 0.56 6.71 0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs2835872 0.758 rs1709833 chr21:39037805 C/T cg06728970 chr21:39037746 KCNJ6 -0.29 -5.25 -0.31 3.09e-7 Electroencephalographic traits in alcoholism; CESC trans rs2391518 0.639 rs2968999 chr4:130784545 G/A cg04981619 chr2:43328122 NA 0.38 6.0 0.35 6.3e-9 Body mass index; CESC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg09323728 chr8:95962352 TP53INP1 -0.4 -8.68 -0.47 4.05e-16 Type 2 diabetes; CESC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg02099474 chr7:1027990 CYP2W1 -0.34 -5.03 -0.3 8.89e-7 Longevity;Endometriosis; CESC cis rs11098499 0.866 rs12374244 chr4:120281972 A/T cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs17376456 0.825 rs12716454 chr5:93272279 A/C cg21475434 chr5:93447410 FAM172A 0.81 6.49 0.37 4.2e-10 Diabetic retinopathy; CESC cis rs2204008 0.604 rs11172718 chr12:38069819 T/C cg13010199 chr12:38710504 ALG10B 0.47 5.83 0.34 1.62e-8 Bladder cancer; CESC cis rs858239 0.669 rs6461687 chr7:23116580 A/G cg23682824 chr7:23144976 KLHL7 0.46 6.21 0.36 2.03e-9 Cerebrospinal fluid biomarker levels; CESC cis rs7116495 0.609 rs73543640 chr11:71834374 G/T cg07596299 chr11:71824057 C11orf51 0.79 5.03 0.3 9.07e-7 Severe influenza A (H1N1) infection; CESC cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.17 14.3 0.66 9.03e-35 Smoking behavior; CESC cis rs4901847 0.562 rs3829765 chr14:58605790 G/A cg15908186 chr14:58618357 C14orf37 0.34 5.12 0.3 5.97e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9291683 0.679 rs3756225 chr4:10094133 G/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.29 -0.5 5.72e-18 Bone mineral density; CESC cis rs5769765 0.728 rs6520064 chr22:50294469 A/G cg26441486 chr22:50317300 CRELD2 0.39 5.41 0.32 1.4e-7 Schizophrenia; CESC cis rs11264213 0.786 rs115087102 chr1:36258854 G/A cg27506609 chr1:36549197 TEKT2 0.65 5.34 0.31 1.97e-7 Schizophrenia; CESC trans rs7246760 0.748 rs61604825 chr19:9726998 C/A cg02900749 chr2:68251473 NA -0.79 -6.02 -0.35 5.78e-9 Pursuit maintenance gain; CESC cis rs9640161 0.789 rs66688634 chr7:150053806 G/A cg27494647 chr7:150038898 RARRES2 0.42 5.09 0.3 6.75e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs2637266 0.935 rs7477361 chr10:78393586 G/A cg18941641 chr10:78392320 NA 0.45 8.59 0.47 7.52e-16 Pulmonary function; CESC cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg21918786 chr6:109611834 NA -0.4 -5.87 -0.34 1.32e-8 Reticulocyte fraction of red cells; CESC cis rs7656342 0.636 rs4697902 chr4:9863936 T/C cg00071950 chr4:10020882 SLC2A9 -0.4 -5.28 -0.31 2.72e-7 Gut microbiota (bacterial taxa); CESC cis rs79057730 0.528 rs6965219 chr7:821807 C/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.7 6.46 0.37 5.11e-10 Initial pursuit acceleration; CESC cis rs4728302 0.869 rs6943986 chr7:133616965 G/A cg10665199 chr7:133106180 EXOC4 0.41 5.42 0.32 1.36e-7 Intelligence;Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05323904 chr16:691677 FAM195A 0.53 6.8 0.39 7.11e-11 Gut microbiota (bacterial taxa); CESC cis rs9457247 1.000 rs402749 chr6:167386104 C/T cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg24675658 chr1:53192096 ZYG11B -0.6 -7.68 -0.43 3.1e-13 Monocyte count; CESC cis rs8070128 0.601 rs8080602 chr17:17954728 G/C cg09796270 chr17:17721594 SREBF1 -0.38 -5.07 -0.3 7.66e-7 Total body bone mineral density; CESC cis rs7208859 0.623 rs77009951 chr17:29080650 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs79247733 0.786 rs2286442 chr22:30772686 C/T cg03868770 chr22:30783737 RNF215 -0.58 -5.88 -0.34 1.25e-8 Tonsillectomy; CESC cis rs9549367 0.789 rs2287247 chr13:113889212 A/G cg00898013 chr13:113819073 PROZ -0.52 -7.2 -0.4 6.09e-12 Platelet distribution width; CESC cis rs977987 0.835 rs8046109 chr16:75360096 A/G cg03315344 chr16:75512273 CHST6 0.38 5.45 0.32 1.18e-7 Dupuytren's disease; CESC trans rs724568 0.643 rs6710930 chr2:67923789 T/C cg19718508 chr5:176831858 F12 -0.46 -6.4 -0.37 6.96e-10 Major depressive disorder (broad); CESC cis rs17666538 0.535 rs168062 chr8:632444 T/A cg23958373 chr8:599963 NA 0.77 5.91 0.34 1.07e-8 IgG glycosylation; CESC cis rs533123 0.668 rs414491 chr1:29170159 C/G cg08366446 chr1:29138936 OPRD1 0.55 5.62 0.33 4.93e-8 Schizophrenia; CESC trans rs61931739 0.500 rs6488211 chr12:34375620 A/T cg26384229 chr12:38710491 ALG10B -0.58 -8.42 -0.46 2.33e-15 Morning vs. evening chronotype; CESC cis rs10992471 0.756 rs7848055 chr9:95115492 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.44 -5.58 -0.32 5.98e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg02951883 chr7:2050386 MAD1L1 -0.58 -7.89 -0.44 7.75e-14 Bipolar disorder and schizophrenia; CESC cis rs2730245 0.593 rs842699 chr7:158663404 T/A cg14689365 chr7:158441557 NCAPG2 0.42 5.26 0.31 2.98e-7 Height; CESC cis rs9911578 1.000 rs7215808 chr17:56940742 G/C cg12560992 chr17:57184187 TRIM37 0.93 15.42 0.69 9.91e-39 Intelligence (multi-trait analysis); CESC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg13206674 chr6:150067644 NUP43 0.42 5.93 0.34 9.66e-9 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21828898 chr3:132379245 UBA5;ACAD11 -0.58 -6.42 -0.37 6.26e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22428023 chr1:36851581 STK40 0.59 6.6 0.38 2.29e-10 Gut microbiome composition (summer); CESC cis rs9287719 0.934 rs12692416 chr2:10745627 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC cis rs5758659 1.000 rs134869 chr22:42652074 G/A cg15557168 chr22:42548783 NA -0.5 -8.12 -0.45 1.77e-14 Cognitive function; CESC cis rs9863 0.861 rs11833002 chr12:124446616 G/A cg17562584 chr12:124393655 DNAH10 0.32 5.48 0.32 9.77e-8 White blood cell count; CESC cis rs12042052 0.590 rs16858252 chr1:232949224 A/C cg00951395 chr1:232941775 KIAA1383 0.79 6.77 0.38 8.1e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs4835473 0.932 rs4305468 chr4:144908468 C/G cg25736465 chr4:144833511 NA -0.4 -6.0 -0.35 6.45e-9 Immature fraction of reticulocytes; CESC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg20243544 chr17:37824526 PNMT 0.48 5.96 0.34 7.8e-9 Glomerular filtration rate (creatinine); CESC trans rs9467711 0.606 rs9393712 chr6:26371000 G/C cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC cis rs708547 0.915 rs28605409 chr4:57766261 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -5.35 -0.31 1.88e-7 Response to bleomycin (chromatid breaks); CESC cis rs2733201 1.000 rs1426658 chr15:44338919 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.53 -5.11 -0.3 6.12e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs2191566 0.691 rs8105315 chr19:44588786 T/G cg20607764 chr19:44506953 ZNF230 -0.4 -5.31 -0.31 2.3e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.77 -8.64 -0.47 5.4e-16 Gut microbiome composition (summer); CESC cis rs9325144 0.560 rs6582539 chr12:38630097 C/T cg26384229 chr12:38710491 ALG10B -0.59 -8.72 -0.47 3.03e-16 Morning vs. evening chronotype; CESC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2011503 0.943 rs8100927 chr19:19643636 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC cis rs6547741 1.000 rs11127071 chr2:27838058 C/A cg21248554 chr2:27665150 KRTCAP3 0.24 5.09 0.3 6.94e-7 Oral cavity cancer; CESC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg06873352 chr17:61820015 STRADA 0.73 12.98 0.62 3.9e-30 Prudent dietary pattern; CESC cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg05347473 chr6:146136440 FBXO30 0.65 8.16 0.45 1.32e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs35110281 0.720 rs162394 chr21:44943550 C/G cg21573476 chr21:45109991 RRP1B 0.42 5.87 0.34 1.3e-8 Mean corpuscular volume; CESC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg23978390 chr7:1156363 C7orf50 0.44 5.9 0.34 1.08e-8 Longevity;Endometriosis; CESC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 13.32 0.63 2.4e-31 Platelet count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18035301 chr10:30722695 MAP3K8 0.49 6.2 0.36 2.18e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg04025307 chr7:1156635 C7orf50 0.56 9.49 0.5 1.43e-18 Longevity;Endometriosis; CESC cis rs6691722 0.503 rs3765432 chr1:24706461 A/G cg02336364 chr1:24764700 NIPAL3 0.33 6.65 0.38 1.68e-10 Response to interferon beta in multiple sclerosis; CESC cis rs921968 0.643 rs526134 chr2:219402371 G/A cg02176678 chr2:219576539 TTLL4 0.42 7.44 0.42 1.43e-12 Mean corpuscular hemoglobin concentration; CESC cis rs61931739 0.534 rs10844828 chr12:34303109 C/T cg06521331 chr12:34319734 NA -0.4 -5.48 -0.32 9.85e-8 Morning vs. evening chronotype; CESC cis rs9527 0.590 rs7912517 chr10:104905529 G/A cg04362960 chr10:104952993 NT5C2 0.42 5.28 0.31 2.71e-7 Arsenic metabolism; CESC cis rs887829 0.694 rs869283 chr2:234626287 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.44 -5.35 -0.31 1.88e-7 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs9303401 0.632 rs7222087 chr17:57221619 A/T cg12560992 chr17:57184187 TRIM37 0.44 5.32 0.31 2.22e-7 Cognitive test performance; CESC cis rs9910055 0.552 rs12937114 chr17:42325073 A/G cg19774624 chr17:42201019 HDAC5 -0.48 -6.15 -0.35 2.78e-9 Total body bone mineral density; CESC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.72 0.38 1.12e-10 Bipolar disorder; CESC cis rs7584330 0.737 rs7584314 chr2:238361089 C/T cg14458575 chr2:238380390 NA 0.6 8.32 0.46 4.61e-15 Prostate cancer; CESC cis rs7909074 0.898 rs10793565 chr10:45388231 G/C cg05187965 chr10:45406764 TMEM72 -0.35 -5.54 -0.32 7.41e-8 Mean corpuscular volume; CESC cis rs2456568 0.548 rs10501809 chr11:93666263 C/G cg26875233 chr11:93583750 C11orf90 -0.32 -5.65 -0.33 4.09e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs9902453 0.933 rs1532042 chr17:28504389 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 7.48 0.42 1.11e-12 Coffee consumption (cups per day); CESC cis rs763014 0.932 rs4984898 chr16:641164 G/T cg07343612 chr16:622815 PIGQ -0.5 -6.91 -0.39 3.5e-11 Height; CESC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.38 0.54 2.06e-21 Prudent dietary pattern; CESC cis rs28374715 0.578 rs7169543 chr15:41620405 T/C cg02330683 chr15:41787940 ITPKA 0.49 5.77 0.33 2.23e-8 Ulcerative colitis; CESC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg22535103 chr8:58192502 C8orf71 0.92 10.08 0.53 1.9e-20 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg08470875 chr2:26401718 FAM59B -0.75 -7.79 -0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs12497850 1.000 rs12497850 chr3:48748989 G/T cg03060546 chr3:49711283 APEH 0.43 5.31 0.31 2.31e-7 Parkinson's disease; CESC cis rs920590 0.684 rs7461774 chr8:19666645 G/A cg01411142 chr8:19674711 INTS10 0.58 6.32 0.36 1.08e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.37 -0.54 2.25e-21 Alzheimer's disease; CESC cis rs701145 0.617 rs355775 chr3:154036129 A/G cg16511985 chr3:153974050 SGEF 0.41 5.57 0.32 6.13e-8 Coronary artery disease; CESC cis rs7208859 0.623 rs7219712 chr17:29080570 G/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7539624 0.541 rs10916601 chr1:223897416 G/A cg10100437 chr1:223903862 CAPN2 0.43 5.44 0.32 1.22e-7 Schizophrenia; CESC cis rs7267979 0.844 rs35735333 chr20:25337205 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -14.75 -0.67 2.44e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.46 -7.76 -0.43 1.9e-13 Hemoglobin concentration; CESC cis rs72781680 0.716 rs2712050 chr2:24059408 A/C cg08917208 chr2:24149416 ATAD2B 0.65 6.43 0.37 6e-10 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02222454 chr3:141762828 NA -0.64 -6.98 -0.39 2.33e-11 Gut microbiome composition (summer); CESC cis rs7940866 0.770 rs10791104 chr11:130814893 A/T cg12179176 chr11:130786555 SNX19 0.65 9.73 0.51 2.5e-19 Schizophrenia; CESC cis rs10883723 0.810 rs10786669 chr10:104256094 C/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs10242455 0.702 rs73397481 chr7:99030108 C/T cg25640893 chr7:99214727 ZNF498 1.0 6.34 0.36 9.64e-10 Blood metabolite levels; CESC trans rs17536732 0.786 rs17536842 chr4:162841102 A/T cg06571387 chr2:176964101 HOXD12 -0.49 -6.64 -0.38 1.78e-10 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg07677032 chr17:61819896 STRADA 0.42 5.33 0.31 2.08e-7 Height; CESC cis rs3020736 0.500 rs764481 chr22:42518426 G/A cg15557168 chr22:42548783 NA 0.45 6.51 0.37 3.78e-10 Autism spectrum disorder or schizophrenia; CESC cis rs6083 0.571 rs17190678 chr15:58847372 C/G cg05156742 chr15:59063176 FAM63B -0.69 -9.75 -0.51 2.17e-19 Schizophrenia; CESC cis rs60154123 0.772 rs701942 chr1:210429392 C/G cg21951975 chr1:209979733 IRF6 0.47 6.08 0.35 4.09e-9 Coronary artery disease; CESC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg18876405 chr7:65276391 NA -0.57 -7.63 -0.42 4.14e-13 Aortic root size; CESC cis rs6499255 1.000 rs4985523 chr16:69797192 T/A cg15192750 chr16:69999425 NA 0.48 5.94 0.34 8.91e-9 IgE levels; CESC cis rs7267979 0.966 rs4815414 chr20:25361701 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.23e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs11931598 0.514 rs10937779 chr4:7039326 G/A cg26116260 chr4:7069785 GRPEL1 0.44 6.4 0.37 7.1e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC cis rs2228479 0.681 rs11641790 chr16:89961957 A/G cg04013166 chr16:89971882 TCF25 -0.72 -8.87 -0.48 1.1e-16 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14898140 chr17:66031871 KPNA2 0.68 7.93 0.44 6.04e-14 Gut microbiome composition (summer); CESC cis rs11122272 0.735 rs973254 chr1:231521149 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.22 -0.45 9.37e-15 Hemoglobin concentration; CESC cis rs7577696 0.597 rs375050 chr2:32413765 C/T cg02381751 chr2:32503542 YIPF4 0.46 5.38 0.31 1.67e-7 Inflammatory biomarkers; CESC cis rs2404602 0.647 rs116505114 chr15:77074794 T/C cg23625390 chr15:77176239 SCAPER -0.47 -6.57 -0.37 2.7e-10 Blood metabolite levels; CESC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg05564831 chr3:52568323 NT5DC2 0.46 6.96 0.39 2.61e-11 Bipolar disorder; CESC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg24549020 chr5:56110836 MAP3K1 0.46 5.5 0.32 8.91e-8 Type 2 diabetes; CESC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg26939375 chr7:64535504 NA -0.76 -10.7 -0.55 1.91e-22 Aortic root size; CESC cis rs6747952 0.899 rs12731 chr2:239087912 G/A cg17459225 chr2:239074497 NA 0.33 5.32 0.31 2.18e-7 Mean corpuscular hemoglobin concentration; CESC cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg07507251 chr3:52567010 NT5DC2 0.41 6.13 0.35 3.13e-9 Bipolar disorder; CESC cis rs1728785 1.000 rs1728785 chr16:68591230 G/T cg02972257 chr16:68554789 NA 0.66 7.56 0.42 6.48e-13 Ulcerative colitis; CESC cis rs9325144 0.555 rs4882284 chr12:38710459 C/T cg26384229 chr12:38710491 ALG10B -0.58 -8.36 -0.46 3.54e-15 Morning vs. evening chronotype; CESC cis rs7216064 1.000 rs7224923 chr17:65842265 T/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.83 -0.48 1.49e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs637571 0.522 rs503524 chr11:65751764 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.75 10.84 0.55 6.84e-23 Eosinophil percentage of white cells; CESC cis rs7727544 0.735 rs274558 chr5:131721174 A/G cg24060327 chr5:131705240 SLC22A5 0.68 9.31 0.5 5.12e-18 Blood metabolite levels; CESC trans rs11039798 0.588 rs589834 chr11:48419382 C/G cg15704280 chr7:45808275 SEPT13 -0.62 -6.25 -0.36 1.63e-9 Axial length; CESC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg03806693 chr22:41940476 POLR3H 1.18 13.87 0.65 2.9e-33 Crohn's disease;Inflammatory bowel disease; CESC cis rs818427 0.783 rs57721139 chr5:112223870 G/A cg07820702 chr5:112228657 REEP5 -0.42 -5.23 -0.31 3.48e-7 Total body bone mineral density; CESC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg18252515 chr7:66147081 NA -0.47 -6.41 -0.37 6.57e-10 Aortic root size; CESC cis rs6964587 0.933 rs6465350 chr7:91768615 G/A cg17063962 chr7:91808500 NA 0.59 8.28 0.45 6.05e-15 Breast cancer; CESC cis rs2228479 0.850 rs1800331 chr16:89858417 C/A cg14709524 chr16:89940631 TCF25 0.93 6.97 0.39 2.5e-11 Skin colour saturation; CESC cis rs2281845 0.507 rs7547762 chr1:201088245 A/G cg06714761 chr1:201096289 NA 0.43 6.73 0.38 1.04e-10 Permanent tooth development; CESC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg12463550 chr7:65579703 CRCP 0.49 6.32 0.36 1.1e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07331747 chr5:172410821 ATP6V0E1 0.63 7.21 0.4 5.87e-12 Gut microbiome composition (summer); CESC trans rs1814175 0.754 rs10839453 chr11:49955815 A/T cg15704280 chr7:45808275 SEPT13 -1.03 -21.33 -0.79 1.95e-59 Height; CESC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg06221963 chr1:154839813 KCNN3 0.69 11.72 0.58 7.99e-26 Prostate cancer; CESC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg18876405 chr7:65276391 NA -0.53 -7.25 -0.41 4.64e-12 Aortic root size; CESC cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg26597838 chr10:835615 NA 1.18 11.37 0.57 1.12e-24 Eosinophil percentage of granulocytes; CESC cis rs568617 0.953 rs1151519 chr11:65645831 G/C cg00576331 chr11:65640516 EFEMP2 0.45 5.3 0.31 2.48e-7 Crohn's disease; CESC cis rs1008375 1.000 rs28480159 chr4:17685707 A/C cg16339924 chr4:17578868 LAP3 0.51 6.55 0.37 2.98e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3617 0.573 rs3821873 chr3:52913006 C/T cg11645453 chr3:52864694 ITIH4 -0.27 -5.39 -0.31 1.57e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg07636037 chr3:49044803 WDR6 1.01 17.62 0.73 1.54e-46 Parkinson's disease; CESC cis rs7208859 0.673 rs11080135 chr17:29176481 A/G cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12498409 chr7:40174463 C7orf10;C7orf11 -0.4 -6.18 -0.35 2.44e-9 Gambling; CESC cis rs12541635 0.677 rs1496183 chr8:107024445 C/T cg10147462 chr8:107024639 NA 0.48 7.39 0.41 1.94e-12 Age of smoking initiation; CESC cis rs11191205 0.865 rs11191161 chr10:103726528 C/T cg15320455 chr10:103880129 LDB1 -0.76 -6.82 -0.39 6.22e-11 Intelligence (multi-trait analysis); CESC cis rs2130392 0.926 rs1107907 chr4:185620108 G/T cg21366198 chr4:185655624 MLF1IP -0.5 -6.95 -0.39 2.76e-11 Kawasaki disease; CESC cis rs6964587 1.000 rs11981461 chr7:91692662 A/G cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.45e-15 Breast cancer; CESC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC trans rs694739 0.595 rs11542299 chr11:64138805 T/C cg01888411 chr11:34378293 ABTB2 0.41 6.17 0.35 2.57e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs1322639 0.574 rs9364360 chr6:169580174 G/A cg03254818 chr6:169586852 NA 0.55 5.95 0.34 8.28e-9 Pulse pressure; CESC cis rs7264396 0.790 rs2425097 chr20:34308926 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.41 -0.57 8.82e-25 Total cholesterol levels; CESC cis rs9914578 1.000 rs62067978 chr17:2013058 G/A cg16513277 chr17:2031491 SMG6 -0.62 -7.04 -0.4 1.67e-11 Body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12642705 chr10:135124069 ZNF511;TUBGCP2 0.52 7.54 0.42 7.7e-13 Gut microbiota (bacterial taxa); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19495351 chr2:210675091 UNC80 0.36 6.11 0.35 3.53e-9 Gambling; CESC cis rs1395 0.778 rs62128747 chr2:27412605 T/C cg22903471 chr2:27725779 GCKR -0.42 -5.21 -0.3 3.81e-7 Blood metabolite levels; CESC cis rs3741798 1.000 rs77559638 chr12:12499909 T/A cg08615371 chr12:12503544 MANSC1 0.86 6.1 0.35 3.73e-9 Cerebrospinal fluid biomarker levels; CESC cis rs9488822 0.636 rs10872142 chr6:116369052 C/A cg18764771 chr6:116381957 FRK 0.23 5.72 0.33 2.83e-8 Cholesterol, total;LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13876481 chr6:147124881 C6orf103;LOC729176 -0.65 -7.66 -0.43 3.42e-13 Gut microbiome composition (summer); CESC cis rs2985684 0.789 rs7161649 chr14:50064028 A/G cg04989706 chr14:50066350 PPIL5 -0.46 -5.15 -0.3 5.08e-7 Carotid intima media thickness; CESC cis rs2370759 1.000 rs11599522 chr10:32568434 G/C cg18270830 chr10:32634957 EPC1 0.72 7.18 0.4 6.85e-12 Sexual dysfunction (female); CESC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.86 8.39 0.46 2.99e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg19163074 chr7:65112434 INTS4L2 0.5 5.21 0.31 3.72e-7 Aortic root size; CESC cis rs858239 0.720 rs10227559 chr7:23272144 G/A cg23682824 chr7:23144976 KLHL7 0.42 5.22 0.31 3.65e-7 Cerebrospinal fluid biomarker levels; CESC cis rs1865721 0.771 rs4410169 chr18:73138840 A/G cg26385618 chr18:73139727 C18orf62 -0.49 -8.0 -0.44 3.82e-14 Intelligence; CESC cis rs7814319 0.933 rs13261690 chr8:97238661 C/A cg20787634 chr8:97240163 UQCRB -0.63 -8.18 -0.45 1.2e-14 Lung function (FVC); CESC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg04234412 chr22:24373322 LOC391322 0.74 9.58 0.51 7.26e-19 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs3008870 0.755 rs2755254 chr1:67470855 C/T cg02640540 chr1:67518911 SLC35D1 0.45 5.49 0.32 9.28e-8 Lymphocyte percentage of white cells; CESC cis rs6964587 0.633 rs13231620 chr7:91507859 G/A cg17063962 chr7:91808500 NA -0.45 -5.31 -0.31 2.36e-7 Breast cancer; CESC cis rs763121 0.819 rs8137829 chr22:39061030 G/A cg06544989 chr22:39130855 UNC84B 0.49 8.49 0.46 1.53e-15 Menopause (age at onset); CESC trans rs12542260 0.871 rs72713049 chr8:125484088 T/G cg09438698 chr12:133365205 GOLGA3 -0.47 -6.05 -0.35 4.83e-9 Colonoscopy-negative controls vs population controls; CESC cis rs826838 0.967 rs1352123 chr12:39130992 T/C cg13010199 chr12:38710504 ALG10B -0.45 -6.27 -0.36 1.48e-9 Heart rate; CESC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.53 7.88 0.44 8.44e-14 Bipolar disorder; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg02070114 chr5:139555300 C5orf32 0.47 6.1 0.35 3.79e-9 Thyroid stimulating hormone; CESC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg05368731 chr17:41323189 NBR1 0.79 11.2 0.57 4.19e-24 Menopause (age at onset); CESC cis rs6460942 0.591 rs62451461 chr7:12355480 G/A cg06484146 chr7:12443880 VWDE -0.62 -6.6 -0.38 2.28e-10 Coronary artery disease; CESC cis rs7824557 0.620 rs6996368 chr8:11182704 G/A cg21775007 chr8:11205619 TDH 0.53 8.21 0.45 9.83e-15 Retinal vascular caliber; CESC cis rs2033562 0.505 rs9297327 chr8:103540181 A/C cg09916692 chr8:103549622 NA -0.36 -6.89 -0.39 4.04e-11 IgA nephropathy; CESC cis rs72901758 0.661 rs56683270 chr17:76247827 T/C cg26068271 chr17:76253126 NA 0.44 6.6 0.38 2.22e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg11494091 chr17:61959527 GH2 0.73 12.56 0.61 1.07e-28 Prudent dietary pattern; CESC cis rs6076065 0.962 rs2424529 chr20:23369317 A/G cg11657817 chr20:23433608 CST11 0.35 5.2 0.3 3.92e-7 Facial morphology (factor 15, philtrum width); CESC cis rs4900538 0.927 rs1190547 chr14:102905087 G/C cg18135206 chr14:102964638 TECPR2 -0.78 -10.3 -0.53 3.94e-21 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7103648 0.669 rs11039332 chr11:47695840 G/A cg10504702 chr11:47789108 FNBP4 0.44 5.5 0.32 8.74e-8 Diastolic blood pressure;Systolic blood pressure; CESC cis rs12142240 0.698 rs72677585 chr1:46812374 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.29 0.36 1.33e-9 Menopause (age at onset); CESC cis rs58688157 0.542 rs7926440 chr11:589819 C/T cg02461776 chr11:598696 PHRF1 0.53 5.95 0.34 8.61e-9 Systemic lupus erythematosus; CESC cis rs6665290 0.935 rs6670924 chr1:227196048 A/C cg10327440 chr1:227177885 CDC42BPA -1.22 -32.88 -0.9 1.62e-95 Myeloid white cell count; CESC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg14703610 chr5:56206110 C5orf35 0.48 6.44 0.37 5.59e-10 Breast cancer;Breast cancer (early onset); CESC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg18230493 chr5:56204884 C5orf35 -0.75 -8.9 -0.48 9.02e-17 Initial pursuit acceleration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05160409 chr11:60681264 TMEM109 0.43 6.24 0.36 1.68e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2072732 0.898 rs2981856 chr1:2972524 T/C cg15211996 chr1:2936768 ACTRT2 0.33 5.91 0.34 1.02e-8 Plateletcrit; CESC cis rs4268898 0.662 rs2303296 chr2:24432839 A/G cg20701182 chr2:24300061 SF3B14 0.68 7.16 0.4 7.75e-12 Asthma; CESC cis rs10751667 0.643 rs7396767 chr11:938808 G/A cg06064525 chr11:970664 AP2A2 -0.52 -10.43 -0.54 1.43e-21 Alzheimer's disease (late onset); CESC cis rs1707322 0.752 rs11211152 chr1:46114157 C/T cg03146154 chr1:46216737 IPP 0.82 11.51 0.58 3.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10000825 chr7:131012516 MKLN1 0.72 8.38 0.46 3.24e-15 Gut microbiome composition (summer); CESC cis rs4664293 0.967 rs3940435 chr2:160494783 G/A cg08347373 chr2:160653686 CD302 -0.32 -5.12 -0.3 5.87e-7 Monocyte percentage of white cells; CESC cis rs2228479 0.850 rs117285117 chr16:89910250 T/G cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs7917772 0.503 rs56219824 chr10:104302337 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.33 0.41 2.81e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg10523679 chr1:76189770 ACADM 0.68 6.56 0.37 2.76e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs72627509 0.857 rs56155140 chr4:57824451 G/A cg26694713 chr4:57773883 REST 0.55 5.36 0.31 1.79e-7 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9291683 0.609 rs34709913 chr4:10028955 T/C cg02734326 chr4:10020555 SLC2A9 0.48 6.72 0.38 1.1e-10 Bone mineral density; CESC cis rs9399135 0.967 rs6923827 chr6:135335382 C/T cg24558204 chr6:135376177 HBS1L 0.48 6.6 0.38 2.21e-10 Red blood cell count; CESC cis rs2070488 0.775 rs6599204 chr3:38525734 C/T cg24069376 chr3:38537580 EXOG 0.32 5.27 0.31 2.87e-7 Electrocardiographic conduction measures; CESC cis rs6963495 0.818 rs73190158 chr7:105153943 T/C cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs888194 0.587 rs6606711 chr12:109849297 A/G cg19025524 chr12:109796872 NA -0.47 -6.83 -0.39 5.64e-11 Neuroticism; CESC cis rs708547 0.676 rs11133470 chr4:57864926 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.5 -6.71 -0.38 1.17e-10 Response to bleomycin (chromatid breaks); CESC cis rs1355223 0.583 rs2915177 chr11:34880266 A/G cg11058730 chr11:34937778 PDHX;APIP 0.84 12.93 0.62 5.8e-30 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs597539 0.690 rs615644 chr11:68621806 G/C cg04772025 chr11:68637568 NA 0.52 5.79 0.34 1.98e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg18876405 chr7:65276391 NA -0.7 -9.84 -0.52 1.15e-19 Calcium levels; CESC cis rs1465370 0.720 rs7811462 chr7:130017487 G/A cg04743876 chr7:130013617 NA 0.31 5.86 0.34 1.38e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC trans rs11039798 0.588 rs12294395 chr11:48476860 C/T cg03929089 chr4:120376271 NA 0.6 6.01 0.35 5.97e-9 Axial length; CESC cis rs977987 0.835 rs3851733 chr16:75370263 G/C cg03315344 chr16:75512273 CHST6 0.38 5.38 0.31 1.63e-7 Dupuytren's disease; CESC cis rs2243480 0.711 rs2460426 chr7:65623129 A/G cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.25e-32 Diabetic kidney disease; CESC trans rs274437 0.739 rs10457998 chr6:104790542 C/A cg23629166 chr1:2345368 PEX10 0.56 6.04 0.35 5.16e-9 Colonoscopy-negative controls vs population controls; CESC cis rs10883723 0.810 rs3740406 chr10:104272789 C/T cg22532475 chr10:104410764 TRIM8 -0.33 -5.68 -0.33 3.5e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg24634471 chr8:143751801 JRK -0.43 -5.15 -0.3 5.14e-7 Urinary tract infection frequency; CESC cis rs11785693 0.862 rs62491189 chr8:4991309 T/C cg26367366 chr8:4980734 NA 0.88 8.07 0.44 2.52e-14 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs8141529 0.732 rs6005872 chr22:29172898 T/G cg15103426 chr22:29168792 CCDC117 0.72 10.07 0.53 2.05e-20 Lymphocyte counts; CESC cis rs6120849 0.901 rs6060270 chr20:33736814 G/T cg24642439 chr20:33292090 TP53INP2 0.63 6.68 0.38 1.37e-10 Protein C levels; CESC cis rs8014204 0.935 rs3742786 chr14:75373011 A/G cg26191576 chr14:75389716 RPS6KL1 0.36 5.22 0.31 3.57e-7 Caffeine consumption; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13357752 chr19:4639397 TNFAIP8L1 0.63 6.95 0.39 2.88e-11 Gut microbiome composition (summer); CESC cis rs11048434 0.673 rs11611106 chr12:9060204 A/C cg04155231 chr12:9217510 LOC144571 -0.32 -5.17 -0.3 4.53e-7 Sjögren's syndrome; CESC cis rs9522267 1.000 rs9522266 chr13:112195456 C/T cg10483660 chr13:112241077 NA -0.3 -5.04 -0.3 8.69e-7 Hepatitis; CESC cis rs735396 0.770 rs1169314 chr12:121443116 A/G cg02403541 chr12:121454288 C12orf43 0.75 10.51 0.54 8.26e-22 N-glycan levels; CESC cis rs1153858 1.000 rs56806728 chr15:45637814 A/G cg14582100 chr15:45693742 SPATA5L1 0.42 6.08 0.35 4.2e-9 Homoarginine levels; CESC cis rs9291683 0.530 rs882223 chr4:9981625 A/C cg02734326 chr4:10020555 SLC2A9 0.46 6.9 0.39 3.73e-11 Bone mineral density; CESC cis rs12765878 1.000 rs9325507 chr10:105645622 C/T cg11005552 chr10:105648138 OBFC1 0.36 5.18 0.3 4.42e-7 Coronary artery disease; CESC cis rs11155671 0.546 rs1999633 chr6:150187712 C/T cg01145232 chr6:150245071 RAET1G 0.44 5.89 0.34 1.16e-8 Testicular germ cell tumor; CESC cis rs559928 0.606 rs56207008 chr11:63883215 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.65 5.82 0.34 1.71e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs6499255 0.951 rs1437135 chr16:69757828 A/G cg15192750 chr16:69999425 NA 0.47 5.47 0.32 1.06e-7 IgE levels; CESC cis rs4803468 0.967 rs3786553 chr19:41902746 T/G cg09537434 chr19:41945824 ATP5SL -1.01 -18.06 -0.74 4.5e-48 Height; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06710522 chr17:45908972 MRPL10;LRRC46 0.42 6.04 0.35 5.14e-9 Systemic lupus erythematosus; CESC cis rs9790314 0.967 rs7623206 chr3:160971518 G/A cg03342759 chr3:160939853 NMD3 -0.47 -6.21 -0.36 2.05e-9 Morning vs. evening chronotype; CESC cis rs4973397 0.810 rs12694890 chr2:232276553 A/T cg09339159 chr2:232260559 B3GNT7 -0.59 -6.14 -0.35 2.97e-9 Anti-saccade response; CESC cis rs9611519 0.780 rs9611542 chr22:41677317 C/T cg03806693 chr22:41940476 POLR3H -0.73 -8.3 -0.45 5.44e-15 Neuroticism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07216194 chr8:27182965 PTK2B 0.53 7.27 0.41 3.94e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg17221315 chr6:27791827 HIST1H4J 0.45 5.8 0.34 1.85e-8 Cardiac Troponin-T levels; CESC cis rs2242194 0.816 rs11264296 chr1:154994750 T/C cg12436631 chr1:155007014 DCST1;DCST2 0.46 8.12 0.45 1.83e-14 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23954629 chr11:120895111 TBCEL 0.6 6.45 0.37 5.39e-10 Gut microbiome composition (summer); CESC cis rs7937682 0.640 rs587010 chr11:111425658 C/A cg22437258 chr11:111473054 SIK2 0.61 7.58 0.42 5.87e-13 Primary sclerosing cholangitis; CESC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg18904891 chr8:8559673 CLDN23 0.69 8.06 0.44 2.63e-14 Obesity-related traits; CESC cis rs643506 0.790 rs688095 chr11:111678771 T/C cg09085632 chr11:111637200 PPP2R1B 0.4 5.31 0.31 2.32e-7 Breast cancer; CESC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg13206674 chr6:150067644 NUP43 0.42 6.1 0.35 3.66e-9 Lung cancer; CESC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25120284 chr17:46894671 TTLL6 0.53 6.07 0.35 4.52e-9 Gut microbiome composition (summer); CESC cis rs1865721 0.728 rs67357037 chr18:73219024 G/T cg26385618 chr18:73139727 C18orf62 -0.53 -7.75 -0.43 2.02e-13 Intelligence; CESC cis rs736801 0.504 rs2070721 chr5:131825842 T/G cg00255919 chr5:131827918 IRF1 0.38 6.4 0.37 7.09e-10 Breast cancer;Mosquito bite size; CESC cis rs12824058 0.831 rs7485200 chr12:130811641 C/T cg26677194 chr12:130822605 PIWIL1 0.54 7.1 0.4 1.14e-11 Menopause (age at onset); CESC cis rs4664308 1.000 rs1511218 chr2:160906390 T/C cg03641300 chr2:160917029 PLA2R1 -0.67 -10.16 -0.53 1.08e-20 Idiopathic membranous nephropathy; CESC cis rs7615952 1.000 rs7616044 chr3:125649354 G/C cg05084668 chr3:125655381 ALG1L -0.5 -6.1 -0.35 3.71e-9 Blood pressure (smoking interaction); CESC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg17949981 chr6:28129498 ZNF389 0.46 5.76 0.33 2.3e-8 Depression; CESC cis rs11098499 0.865 rs9996417 chr4:120295862 T/C cg09307838 chr4:120376055 NA 0.94 12.84 0.62 1.16e-29 Corneal astigmatism; CESC cis rs9303280 0.901 rs2305479 chr17:38062217 C/T cg19468946 chr17:37922297 IKZF3 -0.42 -5.7 -0.33 3.27e-8 Self-reported allergy; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg26887379 chr1:12677936 DHRS3 -0.46 -6.05 -0.35 4.89e-9 Height; CESC cis rs9902453 0.817 rs12051834 chr17:28192785 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.21 0.45 9.9e-15 Coffee consumption (cups per day); CESC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg25767906 chr1:53392781 SCP2 0.43 5.86 0.34 1.37e-8 Monocyte count; CESC trans rs17536732 0.786 rs17458754 chr4:162844633 A/T cg12177677 chr2:158300475 CYTIP -0.62 -6.12 -0.35 3.41e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs854765 0.583 rs8070128 chr17:17804725 C/T cg16928487 chr17:17741425 SREBF1 0.58 9.93 0.52 5.75e-20 Total body bone mineral density; CESC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg09177884 chr7:1199841 ZFAND2A -0.54 -6.11 -0.35 3.61e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg21433313 chr16:3507492 NAT15 -0.61 -6.63 -0.38 1.84e-10 Tuberculosis; CESC cis rs3806843 1.000 rs1548699 chr5:140164918 T/C cg26395211 chr5:140044315 WDR55 -0.42 -5.31 -0.31 2.31e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2235642 0.893 rs2143285 chr16:1593171 A/G cg09080909 chr16:1797204 MAPK8IP3 -0.38 -5.17 -0.3 4.68e-7 Coronary artery disease; CESC cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg20503657 chr10:835505 NA 0.57 5.17 0.3 4.53e-7 Eosinophil percentage of granulocytes; CESC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg07701084 chr6:150067640 NUP43 0.4 5.44 0.32 1.2e-7 Lung cancer; CESC cis rs7799006 0.723 rs2270052 chr7:2291399 C/T cg12745145 chr7:2261452 MAD1L1 -0.32 -5.13 -0.3 5.67e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg02725872 chr8:58115012 NA -0.34 -5.29 -0.31 2.51e-7 Developmental language disorder (linguistic errors); CESC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg09359103 chr1:154839909 KCNN3 -0.69 -13.47 -0.64 7.53e-32 Prostate cancer; CESC cis rs9649213 0.614 rs62479858 chr7:97924226 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.46 -5.99 -0.35 6.93e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg23203755 chr3:149182974 NA 0.45 6.14 0.35 3.02e-9 Recombination measurement; CESC cis rs7474896 0.559 rs2753880 chr10:38173338 G/A cg25427524 chr10:38739819 LOC399744 0.51 5.8 0.34 1.85e-8 Obesity (extreme); CESC cis rs1153858 0.943 rs11070454 chr15:45680252 C/T cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs11098499 1.000 rs7659194 chr4:120207147 T/G cg24375607 chr4:120327624 NA 0.41 5.03 0.3 9e-7 Corneal astigmatism; CESC cis rs11587400 0.679 rs6537836 chr1:115108923 T/C cg12756093 chr1:115239321 AMPD1 0.43 5.76 0.33 2.27e-8 Autism; CESC cis rs9488822 0.636 rs12201275 chr6:116314563 C/G cg26893134 chr6:116381904 FRK 0.25 6.14 0.35 3.05e-9 Cholesterol, total;LDL cholesterol; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg00187635 chr16:83986795 OSGIN1 -0.45 -6.12 -0.35 3.44e-9 Bronchopulmonary dysplasia; CESC cis rs6714710 0.603 rs7583868 chr2:98588372 C/A cg26665480 chr2:98280029 ACTR1B 0.56 7.87 0.44 8.96e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs6460942 1.000 rs7808819 chr7:12297440 C/T cg20607287 chr7:12443886 VWDE -0.74 -7.84 -0.43 1.08e-13 Coronary artery disease; CESC cis rs6964587 0.773 rs13223564 chr7:91932666 A/G cg17063962 chr7:91808500 NA 0.54 6.76 0.38 8.76e-11 Breast cancer; CESC cis rs9467711 0.606 rs68112369 chr6:26365759 T/C cg12826209 chr6:26865740 GUSBL1 0.61 5.13 0.3 5.57e-7 Autism spectrum disorder or schizophrenia; CESC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg22920501 chr2:26401640 FAM59B -0.75 -9.07 -0.49 2.83e-17 Gut microbiome composition (summer); CESC cis rs6942756 0.806 rs2566886 chr7:128917866 G/A cg02491457 chr7:128862824 NA 0.65 9.41 0.5 2.51e-18 White matter hyperintensity burden; CESC cis rs225245 0.791 rs3890901 chr17:34011322 A/C cg05299278 chr17:33885742 SLFN14 0.37 5.35 0.31 1.9e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg01840591 chr16:19179931 SYT17 0.45 6.57 0.37 2.67e-10 Positive affect; CESC cis rs939574 0.790 rs72955439 chr2:220090804 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.88 7.38 0.41 2e-12 Platelet distribution width; CESC cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg12334488 chr2:20871173 GDF7 0.37 6.11 0.35 3.55e-9 Abdominal aortic aneurysm; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03642513 chr4:71859104 DCK 0.5 6.61 0.38 2.14e-10 Systemic lupus erythematosus; CESC cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg26408565 chr15:76604113 ETFA -0.41 -6.01 -0.35 6.01e-9 Blood metabolite levels; CESC cis rs8060686 0.591 rs255054 chr16:68017356 A/G cg26727032 chr16:67993705 SLC12A4 -0.5 -5.73 -0.33 2.68e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs911555 0.706 rs10129426 chr14:104018455 C/T cg24130564 chr14:104152367 KLC1 -0.56 -8.12 -0.45 1.8e-14 Intelligence (multi-trait analysis); CESC cis rs9902453 1.000 rs4581755 chr17:28427898 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 7.95 0.44 5.29e-14 Coffee consumption (cups per day); CESC cis rs7662987 0.517 rs4235436 chr4:100039620 G/A cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg13114125 chr14:105738426 BRF1 -0.71 -9.13 -0.49 1.82e-17 Mean platelet volume;Platelet distribution width; CESC cis rs9291683 0.588 rs3756238 chr4:10013202 C/T cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.5e-12 Bone mineral density; CESC cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg00080972 chr5:178986291 RUFY1 0.39 5.69 0.33 3.32e-8 Lung cancer; CESC cis rs616402 0.527 rs10779737 chr1:10580275 C/G cg20482658 chr1:10539492 PEX14 -0.28 -6.04 -0.35 5.19e-9 Breast size; CESC cis rs8067545 0.611 rs733794 chr17:20157957 T/C cg13482628 chr17:19912719 NA -0.42 -5.61 -0.33 5.03e-8 Schizophrenia; CESC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg10691866 chr7:65817282 TPST1 -0.31 -5.22 -0.31 3.56e-7 Aortic root size; CESC cis rs9902453 0.868 rs8066602 chr17:28523085 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 8.09 0.45 2.15e-14 Coffee consumption (cups per day); CESC cis rs3931020 0.508 rs11485298 chr1:75217752 C/T cg10128416 chr1:75198403 TYW3;CRYZ 0.44 5.34 0.31 1.97e-7 Resistin levels; CESC cis rs9926296 0.715 rs2115401 chr16:89740609 A/G cg04287289 chr16:89883240 FANCA 0.4 5.2 0.3 3.96e-7 Vitiligo; CESC cis rs55788414 0.932 rs729265 chr16:81183600 G/A cg06400318 chr16:81190750 PKD1L2 -0.6 -7.09 -0.4 1.22e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs6088590 0.931 rs6088617 chr20:33408036 G/A cg06115741 chr20:33292138 TP53INP2 0.61 7.59 0.42 5.47e-13 Coronary artery disease; CESC cis rs703842 0.616 rs10783851 chr12:58231155 A/G cg00677455 chr12:58241039 CTDSP2 -0.7 -9.22 -0.49 9.76e-18 Multiple sclerosis; CESC cis rs17001868 0.568 rs9611329 chr22:40792038 G/T cg07138101 chr22:40742427 ADSL 0.52 5.32 0.31 2.17e-7 Mammographic density (dense area); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05332869 chr20:39658073 TOP1 -0.5 -7.17 -0.4 7.65e-12 Gambling; CESC cis rs12477438 0.572 rs10170063 chr2:99655639 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs7520050 0.807 rs4468203 chr1:46113272 T/C cg03146154 chr1:46216737 IPP 0.52 6.88 0.39 4.28e-11 Red blood cell count;Reticulocyte count; CESC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg07677032 chr17:61819896 STRADA 0.45 5.89 0.34 1.14e-8 Prudent dietary pattern; CESC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg11764359 chr7:65958608 NA 0.96 15.23 0.68 4.78e-38 Aortic root size; CESC cis rs2243480 1.000 rs34193460 chr7:65393110 A/G cg13147721 chr7:65941812 NA -0.88 -8.09 -0.45 2.17e-14 Diabetic kidney disease; CESC cis rs6690583 0.623 rs12042910 chr1:85452580 G/A cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.13 -0.3 5.47e-7 Glomerular filtration rate (creatinine); CESC cis rs55794721 0.509 rs6699113 chr1:25777743 C/T cg27572855 chr1:25598939 RHD 0.49 8.31 0.45 4.97e-15 Plateletcrit;Mean corpuscular volume; CESC cis rs9322193 1.000 rs9322193 chr6:149919143 T/G cg13206674 chr6:150067644 NUP43 0.38 5.42 0.32 1.31e-7 Lung cancer; CESC cis rs9309473 0.607 rs4641966 chr2:73590806 G/A cg20560298 chr2:73613845 ALMS1 -0.43 -5.78 -0.33 2.13e-8 Metabolite levels; CESC cis rs2576037 0.583 rs578451 chr18:44404525 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -7.33 -0.41 2.85e-12 Personality dimensions; CESC cis rs11920090 0.932 rs2292620 chr3:170724036 T/C cg09710316 chr3:170744871 SLC2A2 0.52 5.89 0.34 1.17e-8 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs2228479 0.850 rs62054609 chr16:89816569 C/A cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs3026101 0.624 rs17635627 chr17:5296059 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.49 6.5 0.37 3.94e-10 Body mass index; CESC cis rs9399137 0.507 rs4896118 chr6:135276065 A/G cg24558204 chr6:135376177 HBS1L -0.65 -8.84 -0.48 1.4e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg11247378 chr22:39784982 NA -0.65 -9.63 -0.51 5e-19 Intelligence (multi-trait analysis); CESC trans rs61931739 0.500 rs7137392 chr12:34447074 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.5 0.42 9.79e-13 Morning vs. evening chronotype; CESC cis rs847577 0.651 rs10464490 chr7:97715319 T/G cg21770322 chr7:97807741 LMTK2 0.64 10.52 0.54 7.29e-22 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27013360 chr6:41040518 NFYA;C6orf130 -0.48 -7.95 -0.44 5.54e-14 Gambling; CESC cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.65 -0.43 3.85e-13 Alzheimer's disease; CESC trans rs61931739 0.500 rs7489132 chr12:34539712 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC cis rs1008375 1.000 rs4698200 chr4:17657051 G/A cg16339924 chr4:17578868 LAP3 0.57 7.13 0.4 9.66e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs244293 0.730 rs11079142 chr17:53021955 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.42 -5.6 -0.33 5.29e-8 Menarche (age at onset); CESC cis rs5750830 0.645 rs756640 chr22:39779300 G/A cg01416388 chr22:39784598 NA -0.5 -6.68 -0.38 1.43e-10 Intelligence (multi-trait analysis); CESC cis rs1707322 0.717 rs1135850 chr1:46093692 G/A cg06784218 chr1:46089804 CCDC17 0.4 7.01 0.4 1.97e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7605827 0.930 rs1015837 chr2:15665847 C/T cg19274914 chr2:15703543 NA 0.33 5.76 0.33 2.28e-8 Educational attainment (years of education); CESC cis rs1707322 0.752 rs12047629 chr1:46162802 G/A cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6088580 0.634 rs4911421 chr20:32998948 T/C cg08999081 chr20:33150536 PIGU -0.65 -11.29 -0.57 2.22e-24 Glomerular filtration rate (creatinine); CESC cis rs2832191 1.000 rs2832183 chr21:30482150 G/A cg24692254 chr21:30365293 RNF160 -0.74 -11.14 -0.56 6.55e-24 Dental caries; CESC cis rs4660306 0.744 rs11211113 chr1:45923668 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.03 0.3 9.16e-7 Homocysteine levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14431266 chr11:67057003 ANKRD13D -0.42 -6.31 -0.36 1.2e-9 Gambling; CESC cis rs1665050 0.534 rs10444841 chr15:59234048 C/G cg05156742 chr15:59063176 FAM63B 0.5 6.42 0.37 6.18e-10 Atopic dermatitis; CESC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg22920501 chr2:26401640 FAM59B -0.87 -10.52 -0.54 7.59e-22 Gut microbiome composition (summer); CESC cis rs7647973 1.000 rs4241407 chr3:49600319 C/T cg02487422 chr3:49467188 NICN1 0.39 5.11 0.3 6.09e-7 Menarche (age at onset); CESC cis rs3858526 0.752 rs11040173 chr11:6009378 A/G cg13902645 chr11:5959945 NA 0.49 5.58 0.32 5.97e-8 DNA methylation (variation); CESC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg04414720 chr1:150670196 GOLPH3L 0.57 7.49 0.42 1.06e-12 Melanoma; CESC cis rs1832871 0.711 rs9456266 chr6:158714422 A/G cg07165851 chr6:158734300 TULP4 0.6 6.59 0.38 2.33e-10 Height; CESC trans rs61931739 0.534 rs10844767 chr12:34152368 C/G cg26384229 chr12:38710491 ALG10B 0.64 9.06 0.49 2.9e-17 Morning vs. evening chronotype; CESC cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg01579765 chr21:45077557 HSF2BP -0.56 -9.39 -0.5 2.85e-18 Mean corpuscular volume; CESC trans rs6054906 0.710 rs6117744 chr20:7265038 A/C cg15387272 chr1:36863509 LSM10 -0.42 -6.1 -0.35 3.67e-9 Response to amphetamines; CESC cis rs2274273 0.714 rs7154889 chr14:55806885 G/A cg04306507 chr14:55594613 LGALS3 0.32 6.38 0.36 7.9e-10 Protein biomarker; CESC cis rs5769765 1.000 rs768619 chr22:50287266 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.2 -0.3 4.05e-7 Schizophrenia; CESC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 6.03 0.35 5.4e-9 Bipolar disorder; CESC cis rs796364 0.806 rs115717210 chr2:201006247 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -6.48 -0.37 4.47e-10 Schizophrenia; CESC trans rs11098499 0.754 rs17049949 chr4:120255290 A/G cg25214090 chr10:38739885 LOC399744 0.64 9.04 0.49 3.46e-17 Corneal astigmatism; CESC cis rs13102973 0.931 rs4561977 chr4:135848936 T/C cg14419869 chr4:135874104 NA 0.33 5.19 0.3 4.29e-7 Subjective well-being; CESC cis rs2745967 0.791 rs12095883 chr1:208109185 G/A cg09788693 chr1:208063733 CD34 0.32 5.1 0.3 6.37e-7 Resting heart rate; CESC cis rs9549260 0.709 rs9549240 chr13:41186644 T/G cg21288729 chr13:41239152 FOXO1 0.63 8.0 0.44 3.79e-14 Red blood cell count; CESC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs7255374 0.566 rs7255904 chr19:41529020 C/T cg20630647 chr19:41531805 NA 0.41 6.38 0.36 8.08e-10 DDT metabolite (p,p'-DDE levels); CESC cis rs2243480 0.522 rs778717 chr7:65848151 G/C cg18252515 chr7:66147081 NA -1.29 -9.65 -0.51 4.59e-19 Diabetic kidney disease; CESC cis rs9911578 1.000 rs12940681 chr17:56933622 T/C cg05425664 chr17:57184151 TRIM37 -0.46 -6.39 -0.37 7.49e-10 Intelligence (multi-trait analysis); CESC cis rs35955747 0.869 rs34873968 chr22:31581773 C/T cg25791279 chr22:32026902 PISD -0.48 -5.75 -0.33 2.42e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs9908102 0.740 rs7216235 chr17:12900383 C/T cg26162695 chr17:12921313 ELAC2 -0.52 -5.68 -0.33 3.46e-8 Schizophrenia; CESC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg04518342 chr5:131593106 PDLIM4 -0.36 -5.21 -0.3 3.8e-7 Blood metabolite levels; CESC cis rs3015497 0.527 rs2934671 chr14:51153081 C/T cg26011998 chr14:51135199 SAV1 -0.6 -6.7 -0.38 1.26e-10 Mean platelet volume; CESC cis rs4233802 1.000 rs4366927 chr2:151138525 T/C cg25300694 chr2:151184358 NA 0.9 7.86 0.43 9.73e-14 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs9487051 0.676 rs6568560 chr6:109592851 G/A cg21918786 chr6:109611834 NA -0.37 -5.41 -0.32 1.39e-7 Reticulocyte fraction of red cells; CESC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg18876405 chr7:65276391 NA -0.56 -7.36 -0.41 2.32e-12 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14527942 chr3:10276383 IRAK2 -0.49 -6.04 -0.35 5.16e-9 Gut microbiome composition (summer); CESC cis rs1878931 0.501 rs37800 chr16:3423648 T/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.78 -10.32 -0.54 3.24e-21 Body mass index (adult); CESC cis rs2011503 0.882 rs56144632 chr19:19368310 G/A cg11584989 chr19:19387371 SF4 0.63 7.56 0.42 6.77e-13 Bipolar disorder; CESC cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg16339924 chr4:17578868 LAP3 0.59 7.32 0.41 2.99e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8141529 1.000 rs132534 chr22:29299806 T/C cg02153584 chr22:29168773 CCDC117 -0.47 -5.63 -0.33 4.64e-8 Lymphocyte counts; CESC cis rs6580649 0.943 rs3803183 chr12:48398080 T/A cg05342945 chr12:48394962 COL2A1 -0.54 -6.51 -0.37 3.81e-10 Lung cancer; CESC cis rs910316 1.000 rs8017642 chr14:75590822 G/A cg08847533 chr14:75593920 NEK9 0.99 19.04 0.76 1.58e-51 Height; CESC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.23 0.41 5.04e-12 Height; CESC cis rs4148883 0.629 rs2602899 chr4:100010128 C/T cg13256891 chr4:100009986 ADH5 0.53 6.87 0.39 4.44e-11 Alcohol dependence; CESC cis rs4711336 1.000 rs11759396 chr6:33656654 C/G cg15676125 chr6:33679581 C6orf125 0.34 5.06 0.3 7.91e-7 Height; CESC cis rs10242455 0.571 rs41258334 chr7:99271808 T/C cg25640893 chr7:99214727 ZNF498 0.96 6.17 0.35 2.53e-9 Blood metabolite levels; CESC cis rs858239 0.539 rs10225608 chr7:23188908 A/G cg23682824 chr7:23144976 KLHL7 0.51 6.83 0.39 5.81e-11 Cerebrospinal fluid biomarker levels; CESC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg08736216 chr1:53307985 ZYG11A -0.38 -6.16 -0.35 2.68e-9 Monocyte count; CESC cis rs7546094 1.000 rs2932532 chr1:113234456 G/A cg22162597 chr1:113214053 CAPZA1 -0.38 -5.88 -0.34 1.22e-8 Platelet distribution width; CESC cis rs965469 1.000 rs2281494 chr20:3235494 A/G cg25506879 chr20:3388711 C20orf194 -0.57 -6.18 -0.36 2.37e-9 IFN-related cytopenia; CESC cis rs10885582 0.781 rs10787535 chr10:116301436 G/A cg17056676 chr10:116301354 ABLIM1 -0.3 -5.38 -0.31 1.61e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs9815354 0.812 rs12186050 chr3:41836879 G/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9325144 0.555 rs7955128 chr12:38684121 A/T cg13010199 chr12:38710504 ALG10B 0.43 5.83 0.34 1.64e-8 Morning vs. evening chronotype; CESC cis rs4925386 0.681 rs2427295 chr20:60927431 G/A cg24112000 chr20:60950667 NA -0.47 -5.89 -0.34 1.14e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg22535103 chr8:58192502 C8orf71 -0.67 -7.19 -0.4 6.53e-12 Developmental language disorder (linguistic errors); CESC cis rs6032067 0.777 rs13038342 chr20:43800232 C/T cg11264863 chr20:43835661 SEMG1 0.5 5.43 0.32 1.27e-7 Blood protein levels; CESC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.91 0.34 1.03e-8 Tonsillectomy; CESC cis rs9303401 0.614 rs34941454 chr17:57102742 T/G cg12560992 chr17:57184187 TRIM37 0.5 5.26 0.31 2.91e-7 Cognitive test performance; CESC cis rs7100689 0.646 rs1538819 chr10:82122523 A/G cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs2732480 0.557 rs2732441 chr12:48723324 C/G cg24011408 chr12:48396354 COL2A1 0.43 5.97 0.34 7.7e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06191203 chr2:152266755 RIF1 -0.41 -6.19 -0.36 2.27e-9 Gambling; CESC cis rs741677 0.713 rs516382 chr17:486431 A/G cg15660573 chr17:549704 VPS53 0.41 5.39 0.31 1.58e-7 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); CESC cis rs10242455 0.702 rs6976017 chr7:99249999 G/A cg25640893 chr7:99214727 ZNF498 0.78 5.24 0.31 3.31e-7 Blood metabolite levels; CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg14159672 chr1:205819179 PM20D1 -0.69 -11.22 -0.57 3.59e-24 Monocyte percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00873937 chr10:69991564 ATOH7 -0.41 -6.29 -0.36 1.34e-9 Gambling; CESC cis rs4595586 0.545 rs2388174 chr12:39389237 G/A cg26384229 chr12:38710491 ALG10B 0.49 7.01 0.4 1.94e-11 Morning vs. evening chronotype; CESC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.49 7.33 0.41 2.77e-12 Total body bone mineral density; CESC cis rs17666538 0.636 rs10107345 chr8:603700 G/T cg26554054 chr8:600488 NA 0.58 5.06 0.3 7.9e-7 IgG glycosylation; CESC trans rs877282 0.853 rs11596346 chr10:756673 A/T cg22713356 chr15:30763199 NA 0.93 8.39 0.46 3e-15 Uric acid levels; CESC cis rs1355223 0.902 rs1578622 chr11:34725915 A/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.24 -0.36 1.68e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10566763 chr6:106773518 ATG5 0.54 6.44 0.37 5.74e-10 Gut microbiome composition (summer); CESC cis rs7216064 1.000 rs7214758 chr17:65880538 T/C cg07042672 chr17:66097459 LOC651250 -0.59 -6.27 -0.36 1.49e-9 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1707322 0.963 rs6690652 chr1:46376692 G/T cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1008375 0.646 rs13103430 chr4:17567355 A/C cg16339924 chr4:17578868 LAP3 -0.54 -6.37 -0.36 8.09e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10924309 0.737 rs4378245 chr1:245852727 G/A cg00036263 chr1:245852353 KIF26B -0.53 -6.94 -0.39 3.05e-11 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs7178572 0.633 rs4886876 chr15:77838491 C/T cg22256960 chr15:77711686 NA -0.53 -6.95 -0.39 2.89e-11 Type 2 diabetes; CESC cis rs1008375 1.000 rs13119927 chr4:17691640 G/A cg27347728 chr4:17578864 LAP3 -0.45 -5.16 -0.3 4.93e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg20503657 chr10:835505 NA 0.87 9.03 0.49 3.67e-17 Eosinophil percentage of granulocytes; CESC trans rs60843830 1.000 rs57542652 chr2:228088 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 8.23 0.45 8.83e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg23018236 chr17:30244563 NA -0.54 -5.08 -0.3 7.08e-7 Hip circumference adjusted for BMI; CESC cis rs12681288 0.645 rs2600509 chr8:989022 C/G cg04851639 chr8:1020857 NA 0.32 6.8 0.39 7.03e-11 Schizophrenia; CESC cis rs9611565 0.765 rs132914 chr22:41805749 T/C cg06481639 chr22:41940642 POLR3H 0.62 6.52 0.37 3.49e-10 Vitiligo; CESC cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.3 -5.11 -0.3 6.27e-7 Hemoglobin concentration; CESC cis rs6582630 0.537 rs1949611 chr12:38373092 C/T cg26384229 chr12:38710491 ALG10B -0.66 -10.0 -0.52 3.39e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs6893300 0.542 rs7736300 chr5:179196898 G/A cg14593053 chr5:179126677 CANX 0.55 8.17 0.45 1.24e-14 Resting heart rate; CESC cis rs6582630 0.519 rs10880576 chr12:38497693 T/C cg13010199 chr12:38710504 ALG10B 0.42 5.49 0.32 9.17e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9858542 1.000 rs6770670 chr3:49686682 T/C cg03060546 chr3:49711283 APEH -0.59 -6.94 -0.39 2.96e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6582630 0.502 rs11182760 chr12:38606273 A/T cg13010199 chr12:38710504 ALG10B 0.53 6.88 0.39 4.41e-11 Drug-induced liver injury (flucloxacillin); CESC cis rs4975616 0.869 rs452932 chr5:1330253 T/C cg07493874 chr5:1342172 CLPTM1L -0.41 -7.93 -0.44 6.2e-14 Lung cancer; CESC cis rs12618769 0.597 rs2309390 chr2:99114310 T/C cg10123293 chr2:99228465 UNC50 0.41 5.44 0.32 1.24e-7 Bipolar disorder; CESC trans rs877282 1.000 rs12775643 chr10:773242 G/A cg22713356 chr15:30763199 NA 1.12 11.31 0.57 1.87e-24 Uric acid levels; CESC cis rs2243480 1.000 rs313820 chr7:65574466 A/C cg18252515 chr7:66147081 NA -1.39 -13.92 -0.65 1.93e-33 Diabetic kidney disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18803079 chr1:64014643 EFCAB7;DLEU2L -0.47 -6.07 -0.35 4.36e-9 Gut microbiota (bacterial taxa); CESC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg22535103 chr8:58192502 C8orf71 -0.92 -10.16 -0.53 1.04e-20 Developmental language disorder (linguistic errors); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10265472 chr16:20753215 THUMPD1 -0.49 -6.31 -0.36 1.16e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs5747327 0.874 rs34891900 chr22:18163158 C/T cg19898043 chr22:18121309 BCL2L13 -0.41 -5.28 -0.31 2.74e-7 Myeloid white cell count;Granulocyte count; CESC cis rs7512552 0.839 rs2794684 chr1:150320571 C/T cg15654264 chr1:150340011 RPRD2 0.39 5.16 0.3 4.81e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs2832191 0.720 rs4643617 chr21:30485278 T/C cg24692254 chr21:30365293 RNF160 -0.8 -12.74 -0.62 2.64e-29 Dental caries; CESC cis rs3771570 1.000 rs62186411 chr2:242236667 A/C cg21155796 chr2:242212141 HDLBP 0.61 5.16 0.3 4.88e-7 Prostate cancer; CESC cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg03676636 chr4:99064102 C4orf37 0.35 5.49 0.32 9.33e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg05585544 chr11:47624801 NA 0.42 6.19 0.36 2.3e-9 Subjective well-being; CESC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.74 -9.81 -0.52 1.39e-19 Mean platelet volume; CESC cis rs6499255 0.951 rs8045705 chr16:69581672 A/G cg15192750 chr16:69999425 NA 0.47 5.51 0.32 8.71e-8 IgE levels; CESC cis rs314370 0.951 rs3757868 chr7:100482720 G/A cg10426581 chr7:100472382 SRRT 0.85 8.22 0.45 9.27e-15 Resting heart rate; CESC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg24562669 chr7:97807699 LMTK2 0.5 7.47 0.42 1.2e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs870825 0.616 rs35533356 chr4:185639134 A/G cg04058563 chr4:185651563 MLF1IP 0.65 7.13 0.4 9.78e-12 Blood protein levels; CESC cis rs8114671 0.967 rs9574 chr20:33764632 C/G cg24642439 chr20:33292090 TP53INP2 0.43 5.31 0.31 2.32e-7 Height; CESC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg08109568 chr15:31115862 NA 0.68 9.54 0.51 1.01e-18 Huntington's disease progression; CESC cis rs9355610 0.727 rs2247315 chr6:167370211 A/C cg25258033 chr6:167368657 RNASET2 -0.39 -5.55 -0.32 6.9e-8 Graves' disease; CESC cis rs9911578 0.785 rs10853008 chr17:56993407 T/C cg05425664 chr17:57184151 TRIM37 0.48 5.8 0.34 1.91e-8 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg26335602 chr6:28129616 ZNF389 0.52 6.78 0.38 7.92e-11 Depression; CESC cis rs8180040 1.000 rs807936 chr3:47322496 C/T cg27129171 chr3:47204927 SETD2 0.66 10.09 0.53 1.82e-20 Colorectal cancer; CESC cis rs6424115 1.000 rs2256179 chr1:24132305 A/G cg10978503 chr1:24200527 CNR2 -0.28 -5.59 -0.32 5.66e-8 Immature fraction of reticulocytes; CESC cis rs9287719 0.601 rs62128635 chr2:10725334 G/C cg00105475 chr2:10696890 NA 0.4 5.35 0.31 1.94e-7 Prostate cancer; CESC cis rs4523957 0.928 rs8077545 chr17:2184555 A/G cg16513277 chr17:2031491 SMG6 -0.6 -8.21 -0.45 9.51e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg25767906 chr1:53392781 SCP2 -0.54 -7.54 -0.42 7.6e-13 Monocyte count; CESC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg11764359 chr7:65958608 NA 0.97 15.5 0.69 5.25e-39 Aortic root size; CESC trans rs9467711 0.606 rs9379852 chr6:26357278 A/G cg06606381 chr12:133084897 FBRSL1 -0.76 -6.87 -0.39 4.66e-11 Autism spectrum disorder or schizophrenia; CESC cis rs2243480 1.000 rs1404147 chr7:65264524 C/T cg25894440 chr7:65020034 NA -0.56 -5.03 -0.3 9.23e-7 Diabetic kidney disease; CESC cis rs7259376 0.807 rs11669254 chr19:22544805 A/G cg02657401 chr19:22469223 NA -0.26 -5.13 -0.3 5.53e-7 Menopause (age at onset); CESC cis rs559928 0.606 rs17773078 chr11:63906224 G/A cg18225595 chr11:63971243 STIP1 0.64 5.82 0.34 1.73e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs6570726 0.935 rs434298 chr6:145846873 G/A cg23711669 chr6:146136114 FBXO30 0.79 11.73 0.58 7.06e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs911555 0.574 rs34251103 chr14:103860063 A/G cg24130564 chr14:104152367 KLC1 0.47 6.11 0.35 3.54e-9 Intelligence (multi-trait analysis); CESC cis rs863345 0.565 rs2220633 chr1:158445272 A/G cg12129480 chr1:158549410 OR10X1 -0.36 -7.17 -0.4 7.34e-12 Pneumococcal bacteremia; CESC cis rs6690583 0.623 rs61769366 chr1:85534062 G/A cg22488158 chr1:85528044 WDR63 0.54 5.04 0.3 8.49e-7 Serum sulfate level; CESC cis rs6942756 0.876 rs822038 chr7:129065477 A/G cg02491457 chr7:128862824 NA -0.52 -7.07 -0.4 1.4e-11 White matter hyperintensity burden; CESC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg15145296 chr3:125709740 NA -0.48 -5.44 -0.32 1.21e-7 Blood pressure (smoking interaction); CESC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs7107174 0.892 rs2510031 chr11:77969956 T/C cg02023728 chr11:77925099 USP35 0.41 6.06 0.35 4.7e-9 Testicular germ cell tumor; CESC cis rs734999 0.588 rs78506337 chr1:2537095 G/A cg20673091 chr1:2541236 MMEL1 0.46 7.78 0.43 1.67e-13 Ulcerative colitis; CESC cis rs668210 0.793 rs677350 chr11:65761967 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.69 7.56 0.42 6.56e-13 Cerebrospinal fluid biomarker levels; CESC cis rs1941023 0.567 rs955019 chr11:60174250 C/T cg08716584 chr11:60157161 MS4A7 -0.41 -6.22 -0.36 1.95e-9 Congenital heart disease (maternal effect); CESC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg07952391 chr2:88470173 THNSL2 0.62 6.03 0.35 5.61e-9 Plasma clusterin levels; CESC cis rs2243480 0.711 rs1626926 chr7:65435792 C/T cg13147721 chr7:65941812 NA -0.87 -8.63 -0.47 5.76e-16 Diabetic kidney disease; CESC cis rs2404618 0.534 rs2214861 chr8:1490604 A/G cg02903104 chr8:1507517 DLGAP2 0.28 5.58 0.32 5.86e-8 Lung cancer; CESC cis rs7264396 0.790 rs6060565 chr20:34285442 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.82 0.43 1.25e-13 Total cholesterol levels; CESC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg17971929 chr21:40555470 PSMG1 1.04 15.93 0.7 1.5e-40 Cognitive function; CESC cis rs6032067 0.641 rs34811768 chr20:43765800 T/C cg10761708 chr20:43804764 PI3 0.55 6.05 0.35 4.95e-9 Blood protein levels; CESC cis rs137603 0.644 rs137620 chr22:39709776 T/C cg01093212 chr22:39715156 SNORD43;RPL3 -0.41 -5.31 -0.31 2.28e-7 Primary biliary cholangitis; CESC cis rs35123781 1.000 rs2336880 chr5:139063728 A/G cg10513866 chr5:139070639 NA -0.38 -5.78 -0.33 2.08e-8 Schizophrenia; CESC cis rs1707322 0.752 rs6662164 chr1:46146230 T/A cg06784218 chr1:46089804 CCDC17 0.37 6.41 0.37 6.57e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg04287289 chr16:89883240 FANCA 0.41 5.39 0.31 1.57e-7 Vitiligo; CESC cis rs854765 0.583 rs8065416 chr17:17851162 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.08 0.4 1.28e-11 Total body bone mineral density; CESC cis rs7786877 0.626 rs11983745 chr7:100223678 T/C cg20848291 chr7:100343083 ZAN -0.67 -6.98 -0.39 2.34e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7107174 0.892 rs11237463 chr11:78060464 A/G cg02023728 chr11:77925099 USP35 0.48 6.35 0.36 9.33e-10 Testicular germ cell tumor; CESC cis rs7582720 1.000 rs6722332 chr2:203745327 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00144180 chr2:240294362 HDAC4 0.51 7.14 0.4 9.09e-12 Fibrinogen levels; CESC cis rs5750830 0.594 rs5757648 chr22:39775156 G/A cg01416388 chr22:39784598 NA -0.54 -7.15 -0.4 8.7e-12 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg05368731 chr17:41323189 NBR1 0.79 10.86 0.55 5.86e-23 Menopause (age at onset); CESC cis rs473651 0.935 rs540636 chr2:239358341 T/C cg18131467 chr2:239335373 ASB1 1.01 20.41 0.78 2.63e-56 Multiple system atrophy; CESC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.12 13.0 0.62 3.12e-30 Gut microbiome composition (summer); CESC cis rs9790314 0.663 rs778648 chr3:160708943 A/G cg04691961 chr3:161091175 C3orf57 -0.38 -5.04 -0.3 8.73e-7 Morning vs. evening chronotype; CESC cis rs11690935 0.959 rs6722757 chr2:172591963 A/G cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.72 -0.67 3.01e-36 Schizophrenia; CESC cis rs6061231 0.556 rs6121571 chr20:60977323 T/G cg22541963 chr20:60982533 CABLES2 0.5 6.18 0.36 2.35e-9 Colorectal cancer; CESC cis rs6540559 0.673 rs41305104 chr1:209950848 G/A cg22029157 chr1:209979665 IRF6 0.65 6.99 0.39 2.28e-11 Cleft lip with or without cleft palate; CESC cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg20503657 chr10:835505 NA 0.7 7.83 0.43 1.21e-13 Eosinophil percentage of granulocytes; CESC cis rs3617 0.539 rs4687687 chr3:52948332 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.32 -5.48 -0.32 1e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs858239 0.601 rs1558313 chr7:23156079 G/A cg23682824 chr7:23144976 KLHL7 0.54 7.47 0.42 1.18e-12 Cerebrospinal fluid biomarker levels; CESC cis rs4689592 0.554 rs66925245 chr4:7071999 C/T cg19539972 chr4:7069911 GRPEL1 -0.71 -7.3 -0.41 3.33e-12 Monocyte percentage of white cells; CESC cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg04733989 chr22:42467013 NAGA 0.45 6.24 0.36 1.73e-9 Cognitive function; CESC cis rs4450798 0.649 rs4684154 chr3:13787411 A/G cg23332027 chr3:13681764 NA 0.39 5.44 0.32 1.23e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18722557 chr10:123734694 NSMCE4A 0.55 6.09 0.35 3.85e-9 Gut microbiome composition (summer); CESC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg08968635 chr6:28129556 ZNF389 0.4 5.17 0.3 4.65e-7 Parkinson's disease; CESC cis rs7917772 0.503 rs2031602 chr10:104307955 G/C cg22532475 chr10:104410764 TRIM8 -0.33 -5.74 -0.33 2.65e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Tonsillectomy; CESC cis rs12618769 0.597 rs4850874 chr2:99069799 G/A cg10123293 chr2:99228465 UNC50 0.41 5.51 0.32 8.7e-8 Bipolar disorder; CESC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg11764359 chr7:65958608 NA 0.72 9.66 0.51 4.29e-19 Aortic root size; CESC cis rs11718455 0.960 rs34019365 chr3:44004735 G/A cg08738300 chr3:44038990 NA 0.46 6.12 0.35 3.34e-9 Coronary artery disease; CESC cis rs9660992 0.710 rs4951184 chr1:205240659 A/T cg21643547 chr1:205240462 TMCC2 -0.48 -6.8 -0.39 7.12e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg27170947 chr2:26402098 FAM59B -0.6 -7.23 -0.41 5.28e-12 Gut microbiome composition (summer); CESC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg18337363 chr3:52569053 NT5DC2 0.32 6.06 0.35 4.6e-9 Electroencephalogram traits; CESC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2204008 0.774 rs11520273 chr12:38354075 A/T cg13010199 chr12:38710504 ALG10B 0.45 5.77 0.33 2.24e-8 Bladder cancer; CESC cis rs10751667 0.600 rs7394783 chr11:1005108 C/T cg06064525 chr11:970664 AP2A2 0.34 5.94 0.34 8.69e-9 Alzheimer's disease (late onset); CESC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg11764359 chr7:65958608 NA 0.79 11.32 0.57 1.67e-24 Aortic root size; CESC cis rs7084402 0.935 rs717453 chr10:60268398 C/T cg07615347 chr10:60278583 BICC1 -0.59 -8.98 -0.48 5.19e-17 Refractive error; CESC cis rs1316952 0.831 rs78985577 chr12:124393117 G/A cg17562584 chr12:124393655 DNAH10 0.4 5.45 0.32 1.15e-7 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs1950626 0.796 rs7152870 chr14:101389987 T/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.79 -10.32 -0.54 3.37e-21 Pelvic organ prolapse (moderate/severe); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22754179 chr19:42901115 NA -0.61 -7.24 -0.41 4.84e-12 Gut microbiome composition (summer); CESC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg21963583 chr11:68658836 MRPL21 0.41 5.73 0.33 2.75e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg08470875 chr2:26401718 FAM59B -0.73 -7.98 -0.44 4.43e-14 Gut microbiome composition (summer); CESC cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg02487422 chr3:49467188 NICN1 0.44 5.54 0.32 7.23e-8 Parkinson's disease; CESC cis rs3091242 0.933 rs10903130 chr1:25769221 A/T cg03538708 chr1:25844672 NA -0.38 -5.69 -0.33 3.37e-8 Erythrocyte sedimentation rate; CESC cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg03433033 chr1:76189801 ACADM -0.73 -10.34 -0.54 2.78e-21 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6088580 0.634 rs6059851 chr20:33047945 G/A cg06115741 chr20:33292138 TP53INP2 0.46 5.97 0.34 7.61e-9 Glomerular filtration rate (creatinine); CESC cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg11644478 chr21:40555479 PSMG1 0.97 14.67 0.67 4.59e-36 Cognitive function; CESC cis rs1348850 0.554 rs7595576 chr2:178371921 C/T cg22681709 chr2:178499509 PDE11A -0.5 -5.16 -0.3 4.97e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7089973 0.966 rs17721283 chr10:116644141 A/G cg23260525 chr10:116636907 FAM160B1 0.34 5.35 0.31 1.92e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs832540 0.898 rs252890 chr5:56226410 T/C cg24531977 chr5:56204891 C5orf35 -0.42 -5.36 -0.31 1.84e-7 Coronary artery disease; CESC cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC trans rs9951602 0.512 rs8097996 chr18:76648035 A/G cg02800362 chr5:177631904 HNRNPAB 0.64 8.28 0.45 5.96e-15 Obesity-related traits; CESC cis rs12545109 0.765 rs1960726 chr8:57411733 T/C cg09654669 chr8:57350985 NA -0.46 -6.28 -0.36 1.4e-9 Obesity-related traits; CESC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg24549020 chr5:56110836 MAP3K1 -0.59 -6.42 -0.37 6.32e-10 Initial pursuit acceleration; CESC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg00149659 chr3:10157352 C3orf10 0.75 9.05 0.49 3.07e-17 Alzheimer's disease; CESC cis rs1538970 0.924 rs1826691 chr1:45881262 A/G cg05343316 chr1:45956843 TESK2 -0.84 -11.74 -0.58 6.88e-26 Platelet count; CESC cis rs8067545 0.750 rs7208635 chr17:19990990 T/C cg13482628 chr17:19912719 NA 0.37 5.09 0.3 6.81e-7 Schizophrenia; CESC trans rs1814175 0.817 rs7924619 chr11:49620632 G/A cg03929089 chr4:120376271 NA -0.91 -14.98 -0.68 3.52e-37 Height; CESC cis rs66887589 0.807 rs13134517 chr4:120405262 G/A cg09307838 chr4:120376055 NA 0.53 7.12 0.4 1.04e-11 Diastolic blood pressure; CESC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg04944784 chr2:26401820 FAM59B -0.63 -7.17 -0.4 7.54e-12 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs9827461 chr3:40489351 T/A cg09455208 chr3:40491958 NA 0.49 7.98 0.44 4.53e-14 Renal cell carcinoma; CESC cis rs965469 0.947 rs4611719 chr20:3228423 G/A cg25506879 chr20:3388711 C20orf194 -0.65 -6.87 -0.39 4.52e-11 IFN-related cytopenia; CESC cis rs2797160 0.904 rs1418637 chr6:125992553 A/G cg05901451 chr6:126070800 HEY2 -0.46 -6.74 -0.38 9.78e-11 Endometrial cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14405528 chr22:47372700 TBC1D22A -0.65 -7.26 -0.41 4.34e-12 Gut microbiome composition (summer); CESC cis rs2841277 0.676 rs10438246 chr14:105410183 T/C cg15352829 chr14:105391018 PLD4 -0.59 -10.4 -0.54 1.75e-21 Rheumatoid arthritis; CESC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg19592336 chr6:28129416 ZNF389 0.52 6.71 0.38 1.18e-10 Parkinson's disease; CESC cis rs35110281 0.776 rs9983763 chr21:44990578 A/G cg01579765 chr21:45077557 HSF2BP 0.53 8.54 0.46 1.07e-15 Mean corpuscular volume; CESC cis rs477895 1.000 rs2286614 chr11:64068310 C/T cg04317338 chr11:64019027 PLCB3 0.71 5.91 0.34 1.07e-8 Mean platelet volume; CESC cis rs72945132 0.825 rs58532402 chr11:70189491 C/T cg00319359 chr11:70116639 PPFIA1 0.72 6.84 0.39 5.42e-11 Coronary artery disease; CESC cis rs1878931 0.580 rs3848355 chr16:3407489 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.98 15.26 0.68 3.53e-38 Body mass index (adult); CESC cis rs5760092 0.755 rs4585126 chr22:24270005 T/C cg01238044 chr22:24384105 GSTT1 0.6 7.26 0.41 4.22e-12 Urinary 1,3-butadiene metabolite levels in smokers; CESC trans rs7246657 0.943 rs1559229 chr19:37876197 T/C cg24637308 chr11:6592297 DNHD1 0.53 6.18 0.35 2.37e-9 Coronary artery calcification; CESC cis rs1865721 0.804 rs4510115 chr18:73209635 G/A cg26385618 chr18:73139727 C18orf62 -0.52 -7.57 -0.42 6.2800000000000005e-13 Intelligence; CESC cis rs10870270 0.956 rs10870281 chr10:133762642 G/A cg08754478 chr10:133766260 PPP2R2D -0.6 -7.68 -0.43 3.1400000000000003e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs854765 0.647 rs741782 chr17:18019712 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.05 0.35 4.83e-9 Total body bone mineral density; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg18395189 chr1:152189015 HRNR -0.43 -6.23 -0.36 1.81e-9 Psoriatic arthritis; CESC cis rs7084402 0.967 rs1658432 chr10:60329069 C/G cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg02297831 chr4:17616191 MED28 0.44 5.34 0.31 1.99e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3540 0.618 rs2301832 chr15:91040725 A/T cg22089800 chr15:90895588 ZNF774 -0.62 -8.17 -0.45 1.26e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs4466137 0.953 rs1420654 chr5:82975793 G/A cg16102102 chr5:83017553 HAPLN1 -0.42 -6.27 -0.36 1.49e-9 Prostate cancer; CESC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg24675658 chr1:53192096 ZYG11B 0.53 6.69 0.38 1.29e-10 Monocyte count; CESC cis rs6541297 0.757 rs642235 chr1:230325027 C/G cg20703242 chr1:230279135 GALNT2 -0.38 -5.12 -0.3 5.99e-7 Coronary artery disease; CESC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg08470875 chr2:26401718 FAM59B -0.75 -7.79 -0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.73 -10.31 -0.54 3.55e-21 Monocyte percentage of white cells; CESC cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg06713675 chr4:122721982 EXOSC9 -0.45 -6.38 -0.36 7.86e-10 Type 2 diabetes; CESC cis rs12545109 0.917 rs1370304 chr8:57322822 G/C cg09654669 chr8:57350985 NA -0.53 -6.62 -0.38 1.99e-10 Obesity-related traits; CESC cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.68 7.74 0.43 2.14e-13 Age-related macular degeneration (geographic atrophy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01806965 chr8:144378397 ZNF696 -0.61 -6.53 -0.37 3.3e-10 Gut microbiome composition (summer); CESC cis rs6754311 0.731 rs3769005 chr2:136603366 C/G cg15123519 chr2:136567270 LCT 0.3 5.16 0.3 4.73e-7 Mosquito bite size; CESC cis rs7923609 0.934 rs10761771 chr10:65230164 T/C cg01631684 chr10:65280961 REEP3 -0.44 -5.44 -0.32 1.2e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs12971120 0.891 rs2278158 chr18:72178300 G/T cg26446133 chr18:72167187 CNDP2 -0.74 -9.14 -0.49 1.69e-17 Refractive error; CESC trans rs3780486 0.541 rs10738909 chr9:33148834 T/C cg04842962 chr6:43655489 MRPS18A 0.68 10.26 0.53 5.21e-21 IgG glycosylation; CESC cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.23e-28 Colonoscopy-negative controls vs population controls; CESC cis rs12458462 0.859 rs2242177 chr18:77477379 G/A cg11879182 chr18:77439856 CTDP1 0.87 13.46 0.64 8.32e-32 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19905802 chr11:62554200 TMEM179B;TAF6L 0.63 7.3 0.41 3.41e-12 Gut microbiome composition (summer); CESC cis rs2180341 0.521 rs12203812 chr6:127617816 A/T cg27446573 chr6:127587934 RNF146 0.52 6.82 0.39 6.12e-11 Breast cancer; CESC cis rs10896135 0.526 rs12795774 chr11:66381517 T/C cg15964523 chr11:66469143 SPTBN2 0.41 5.33 0.31 2.15e-7 Bipolar disorder; CESC cis rs2239908 0.718 rs241776 chr17:26644308 C/T cg10342447 chr17:26645325 TMEM97 0.4 5.51 0.32 8.62e-8 Blood protein levels; CESC cis rs854765 0.583 rs8065416 chr17:17851162 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs5417 0.662 rs8067500 chr17:7172631 A/G cg14660024 chr17:7154518 C17orf81;DULLARD -0.47 -6.31 -0.36 1.17e-9 Diastolic blood pressure; CESC cis rs1153858 1.000 rs7171577 chr15:45627979 G/A cg14582100 chr15:45693742 SPATA5L1 0.41 5.89 0.34 1.18e-8 Homoarginine levels; CESC cis rs7481584 0.886 rs4758621 chr11:3009640 C/T cg25174290 chr11:3078921 CARS 0.48 5.96 0.34 7.91e-9 Calcium levels; CESC cis rs7674212 0.539 rs6850461 chr4:104120041 C/T cg16532752 chr4:104119610 CENPE -0.4 -5.46 -0.32 1.09e-7 Type 2 diabetes; CESC cis rs798554 0.610 rs2644304 chr7:2878779 T/C cg19717773 chr7:2847554 GNA12 -0.51 -8.05 -0.44 2.72e-14 Height; CESC cis rs6500395 0.963 rs12919278 chr16:48692537 A/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1580019 0.885 rs4460269 chr7:32496445 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.72 9.97 0.52 4.3e-20 Cognitive ability; CESC cis rs9303401 0.659 rs12150536 chr17:56640834 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.56e-29 Cognitive test performance; CESC cis rs7017914 0.902 rs1373480 chr8:71686967 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs4253772 0.550 rs6008729 chr22:46727428 C/G cg24881330 chr22:46731750 TRMU -0.82 -8.82 -0.48 1.52e-16 LDL cholesterol;Cholesterol, total; CESC cis rs7178572 0.568 rs11072653 chr15:77693934 C/T cg22256960 chr15:77711686 NA -0.54 -6.95 -0.39 2.9e-11 Type 2 diabetes; CESC cis rs858239 0.698 rs858295 chr7:23245569 A/G cg23682824 chr7:23144976 KLHL7 0.43 5.79 0.34 1.95e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7829975 0.540 rs2976909 chr8:8346690 C/T cg15556689 chr8:8085844 FLJ10661 -0.48 -5.89 -0.34 1.15e-8 Mood instability; CESC cis rs4588572 0.643 rs6861678 chr5:77764613 G/C cg11547950 chr5:77652471 NA -0.44 -5.48 -0.32 9.67e-8 Triglycerides; CESC cis rs2011503 0.943 rs10406278 chr19:19494725 A/C cg11584989 chr19:19387371 SF4 -0.63 -7.42 -0.41 1.63e-12 Bipolar disorder; CESC cis rs7605827 0.930 rs1125534 chr2:15618339 G/A cg19274914 chr2:15703543 NA 0.36 6.41 0.37 6.6e-10 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12245206 chr19:59070421 UBE2M;LOC100131691 0.62 6.8 0.39 7.12e-11 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC cis rs4319547 0.585 rs7953007 chr12:122816977 A/C cg05707623 chr12:122985044 ZCCHC8 -0.48 -5.6 -0.33 5.34e-8 Body mass index; CESC cis rs6582630 0.615 rs12821226 chr12:38546406 C/T cg26384229 chr12:38710491 ALG10B -0.39 -5.19 -0.3 4.22e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs9902453 0.780 rs10445384 chr17:28182685 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 7.32 0.41 2.99e-12 Coffee consumption (cups per day); CESC cis rs870825 0.616 rs2130394 chr4:185642577 C/A cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs6545883 0.929 rs10193666 chr2:61629408 C/T cg15711740 chr2:61764176 XPO1 0.41 5.21 0.3 3.79e-7 Tuberculosis; CESC cis rs6866344 0.697 rs17184302 chr5:178127676 C/T cg10224037 chr5:178157518 ZNF354A 0.67 7.37 0.41 2.13e-12 Neutrophil percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23087020 chr1:167190262 POU2F1 -0.48 -6.79 -0.38 7.22e-11 Gut microbiota (bacterial taxa); CESC cis rs9811920 0.732 rs7613864 chr3:99602470 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.44 5.82 0.34 1.7e-8 Axial length; CESC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg19318889 chr4:1322082 MAEA 0.46 6.03 0.35 5.51e-9 Longevity; CESC cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg04287289 chr16:89883240 FANCA 0.9 15.35 0.69 1.76e-38 Vitiligo; CESC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg18876405 chr7:65276391 NA -0.5 -5.91 -0.34 1.05e-8 Aortic root size; CESC cis rs6087990 0.806 rs4911258 chr20:31369479 G/A cg13636640 chr20:31349939 DNMT3B 0.81 12.5 0.61 1.67e-28 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26852651 chr1:151584651 SNX27 0.55 6.67 0.38 1.48e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03767357 chr7:130353742 COPG2;TSGA13 0.54 6.15 0.35 2.84e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00822591 chr3:16306489 DPH3;OXNAD1 0.56 6.03 0.35 5.36e-9 Gut microbiome composition (summer); CESC cis rs9625935 0.518 rs713718 chr22:30314092 A/C cg01021169 chr22:30184971 ASCC2 0.43 6.78 0.38 7.64e-11 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14489327 chr19:1021257 C19orf6 -0.6 -6.9 -0.39 3.81e-11 Gut microbiome composition (summer); CESC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg23281280 chr6:28129359 ZNF389 -0.56 -7.56 -0.42 6.63e-13 Parkinson's disease; CESC cis rs1278769 0.735 rs9577395 chr13:113534984 C/G cg00823993 chr13:113535758 ATP11A 0.59 7.68 0.43 3e-13 Interstitial lung disease; CESC cis rs631288 0.557 rs894467 chr1:146662018 C/T cg25205988 chr1:146714368 CHD1L 1.04 6.66 0.38 1.58e-10 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs8141529 0.764 rs5752812 chr22:29225603 T/A cg02153584 chr22:29168773 CCDC117 0.64 9.16 0.49 1.46e-17 Lymphocyte counts; CESC cis rs12541635 0.966 rs56352125 chr8:107041831 G/T cg10147462 chr8:107024639 NA 0.43 6.11 0.35 3.49e-9 Age of smoking initiation; CESC cis rs873946 0.689 rs2803993 chr10:134550606 T/C cg18305652 chr10:134549665 INPP5A 0.49 7.43 0.42 1.52e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7903847 0.642 rs10786341 chr10:99158607 G/A cg20016023 chr10:99160130 RRP12 -0.3 -5.19 -0.3 4.18e-7 Granulocyte percentage of myeloid white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05040584 chr10:121411475 BAG3 0.54 6.71 0.38 1.17e-10 Gut microbiome composition (summer); CESC trans rs916888 0.610 rs199529 chr17:44837217 A/C cg22968622 chr17:43663579 NA 0.97 13.11 0.63 1.35e-30 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11235843 1.000 rs11235843 chr11:73373996 A/G cg03538470 chr11:73498718 MRPL48 0.55 5.15 0.3 5.16e-7 Hand grip strength; CESC trans rs7615952 0.736 rs13063122 chr3:125643860 G/A cg07211511 chr3:129823064 LOC729375 -1.11 -15.27 -0.68 3.39e-38 Blood pressure (smoking interaction); CESC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg08859206 chr1:53392774 SCP2 -0.6 -8.05 -0.44 2.89e-14 Monocyte count; CESC cis rs9457247 0.534 rs7750593 chr6:167387359 C/G cg23791538 chr6:167370224 RNASET2 0.7 9.88 0.52 8.62e-20 Crohn's disease; CESC cis rs12368653 0.616 rs1027315 chr12:58034192 T/C cg18357645 chr12:58087776 OS9 0.4 5.75 0.33 2.49e-8 Multiple sclerosis; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg20299458 chr4:62383146 LPHN3 -0.43 -6.12 -0.35 3.42e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs7107770 0.663 rs7111751 chr11:125075288 A/T cg27629782 chr11:125073726 PKNOX2 -0.32 -5.32 -0.31 2.24e-7 Photic sneeze reflex; CESC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg18016565 chr1:150552671 MCL1 0.34 5.03 0.3 9.21e-7 Melanoma; CESC cis rs7264396 0.563 rs56941405 chr20:34313426 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.86 0.39 4.8e-11 Total cholesterol levels; CESC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg02772935 chr3:125709198 NA -0.48 -5.52 -0.32 8.11e-8 Blood pressure (smoking interaction); CESC cis rs2439831 0.850 rs7181039 chr15:44179112 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.64 6.57 0.37 2.63e-10 Lung cancer in ever smokers; CESC cis rs12893668 0.667 rs71417869 chr14:104077434 A/G cg24130564 chr14:104152367 KLC1 -0.54 -6.87 -0.39 4.5e-11 Reticulocyte count; CESC cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg01579765 chr21:45077557 HSF2BP -0.53 -8.85 -0.48 1.25e-16 Mean corpuscular volume; CESC cis rs11509880 0.543 rs10950393 chr7:12263546 T/C cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.51e-7 Coronary artery disease; CESC cis rs2797160 1.000 rs4897153 chr6:126003403 A/G cg05901451 chr6:126070800 HEY2 -0.46 -6.62 -0.38 1.94e-10 Endometrial cancer; CESC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg24531977 chr5:56204891 C5orf35 0.72 9.6 0.51 6.52e-19 Initial pursuit acceleration; CESC trans rs9467711 0.606 rs2073531 chr6:26375256 A/G cg06606381 chr12:133084897 FBRSL1 -0.77 -6.78 -0.38 7.69e-11 Autism spectrum disorder or schizophrenia; CESC cis rs3820068 0.705 rs4646096 chr1:15820758 A/G cg18192808 chr1:15853278 DNAJC16 0.47 5.78 0.33 2.05e-8 Systolic blood pressure; CESC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg18402987 chr7:1209562 NA 0.61 6.46 0.37 4.86e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9287719 0.967 rs4669593 chr2:10701908 C/T cg02196655 chr2:10830764 NOL10 -0.36 -5.42 -0.32 1.31e-7 Prostate cancer; CESC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg24372256 chr21:43528868 UMODL1;C21orf128 -0.53 -8.21 -0.45 9.85e-15 IgG glycosylation; CESC trans rs61869271 0.871 rs6585309 chr10:116730337 A/G cg17463145 chr7:79084011 MAGI2 -0.31 -6.24 -0.36 1.72e-9 Tonsillectomy; CESC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.22e-7 Developmental language disorder (linguistic errors); CESC cis rs559928 0.692 rs915987 chr11:64027888 G/A cg18225595 chr11:63971243 STIP1 0.61 5.14 0.3 5.41e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22215202 chr19:50321460 MED25 0.45 6.14 0.35 2.97e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs360798 0.512 rs2539978 chr2:63195179 T/C cg17519650 chr2:63277830 OTX1 0.57 7.44 0.42 1.38e-12 Coronary artery disease; CESC cis rs3540 0.597 rs3743409 chr15:91045539 T/A cg10434728 chr15:90938212 IQGAP1 -0.42 -7.71 -0.43 2.56e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.77 9.93 0.52 5.92e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs17253792 0.822 rs77408754 chr14:56082047 C/T cg01858014 chr14:56050164 KTN1 -0.93 -7.54 -0.42 7.5e-13 Putamen volume; CESC cis rs5753618 0.561 rs1858821 chr22:31676454 T/C cg13145458 chr22:31556086 RNF185 0.51 5.68 0.33 3.46e-8 Colorectal cancer; CESC cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg05283184 chr6:79620031 NA -0.43 -6.68 -0.38 1.36e-10 Intelligence (multi-trait analysis); CESC cis rs7786808 0.544 rs6971888 chr7:158193835 G/A cg09998033 chr7:158218633 PTPRN2 0.34 5.18 0.3 4.38e-7 Obesity-related traits; CESC cis rs698833 0.926 rs786624 chr2:44604941 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.43 -5.49 -0.32 9.54e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg06636001 chr8:8085503 FLJ10661 0.51 6.56 0.37 2.8e-10 Mood instability; CESC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg18337363 chr3:52569053 NT5DC2 0.29 5.24 0.31 3.31e-7 Electroencephalogram traits; CESC cis rs7618501 0.966 rs13063621 chr3:49821625 T/C cg24308560 chr3:49941425 MST1R -0.5 -6.8 -0.39 7.06e-11 Intelligence (multi-trait analysis); CESC cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg07507251 chr3:52567010 NT5DC2 0.36 5.93 0.34 9.45e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22638185 chr17:42385946 RUNDC3A 0.57 6.42 0.37 6.29e-10 Gut microbiome composition (summer); CESC cis rs4820294 1.000 rs62236667 chr22:38061520 C/G cg21798802 chr22:38057573 PDXP 0.46 7.99 0.44 4.16e-14 Fat distribution (HIV); CESC cis rs7520050 0.966 rs7522601 chr1:46419021 G/A cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.74e-9 Red blood cell count;Reticulocyte count; CESC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg19678392 chr7:94953810 PON1 -0.57 -8.41 -0.46 2.55e-15 Paraoxonase activity; CESC cis rs910316 0.663 rs175034 chr14:75463687 T/G cg11812906 chr14:75593930 NEK9 -0.8 -12.71 -0.62 3.25e-29 Height; CESC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg23758822 chr17:41437982 NA 1.0 15.37 0.69 1.56e-38 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09409496 chr21:38738374 DYRK1A 0.59 7.05 0.4 1.59e-11 Gut microbiome composition (summer); CESC cis rs4692589 1.000 rs17546378 chr4:170935854 G/A cg19918862 chr4:170955249 NA 0.36 5.65 0.33 4.07e-8 Anxiety disorder; CESC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.87e-17 Tonsillectomy; CESC cis rs1003719 0.680 rs3737540 chr21:38523266 C/A cg10648535 chr21:38446584 PIGP;TTC3 -0.5 -6.63 -0.38 1.89e-10 Eye color traits; CESC cis rs763121 0.853 rs1062687 chr22:39134715 T/C cg14440974 chr22:39074834 NA -0.37 -5.3 -0.31 2.44e-7 Menopause (age at onset); CESC cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2243480 1.000 rs4548056 chr7:65298873 A/G cg18252515 chr7:66147081 NA -1.01 -9.63 -0.51 5.21e-19 Diabetic kidney disease; CESC cis rs2011503 1.000 rs17684164 chr19:19626769 C/T cg11584989 chr19:19387371 SF4 0.61 7.06 0.4 1.45e-11 Bipolar disorder; CESC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg18446336 chr7:2847575 GNA12 -0.36 -5.56 -0.32 6.61e-8 Height; CESC cis rs7520050 0.808 rs11211195 chr1:46282295 T/C cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.38e-7 Red blood cell count;Reticulocyte count; CESC cis rs3087591 0.922 rs12939969 chr17:29463577 A/G cg24425628 chr17:29625626 OMG;NF1 0.41 5.06 0.3 7.7300000000000005e-07 Hip circumference; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18927317 chr7:75987610 YWHAG 0.59 6.48 0.37 4.5e-10 Gut microbiome composition (summer); CESC cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg23711669 chr6:146136114 FBXO30 1.01 15.22 0.68 4.99e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg13798912 chr7:905769 UNC84A 0.56 5.63 0.33 4.52e-8 Cerebrospinal P-tau181p levels; CESC cis rs17253792 0.915 rs76952651 chr14:56188994 G/A cg01858014 chr14:56050164 KTN1 -0.94 -7.35 -0.41 2.5e-12 Putamen volume; CESC cis rs561341 0.714 rs75861674 chr17:30304317 A/G cg12193833 chr17:30244370 NA -0.56 -5.78 -0.33 2.15e-8 Hip circumference adjusted for BMI; CESC cis rs11640533 0.901 rs11862250 chr16:53415038 C/A cg02380802 chr16:53407808 NA 0.43 5.59 0.32 5.71e-8 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08269949 chr6:26538502 HMGN4 -0.45 -6.51 -0.37 3.75e-10 Gambling; CESC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg22823121 chr1:150693482 HORMAD1 0.47 6.96 0.39 2.6e-11 Tonsillectomy; CESC cis rs881375 0.678 rs3761846 chr9:123689597 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.43 6.33 0.36 1.06e-9 Rheumatoid arthritis; CESC cis rs7605827 0.930 rs7590458 chr2:15601574 A/G cg19274914 chr2:15703543 NA -0.36 -6.52 -0.37 3.56e-10 Educational attainment (years of education); CESC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg11764359 chr7:65958608 NA -0.78 -11.24 -0.57 3.14e-24 Aortic root size; CESC cis rs9788682 1.000 rs12441354 chr15:78821016 G/A cg24631222 chr15:78858424 CHRNA5 0.77 9.92 0.52 6.29e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs765787 0.530 rs1631533 chr15:45518628 C/T cg24006582 chr15:45444508 DUOX1 -0.57 -6.88 -0.39 4.23e-11 Uric acid levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04709120 chr10:74451858 CCDC109A -0.47 -6.33 -0.36 1.02e-9 Ulcerative colitis; CESC cis rs28374715 0.528 rs7178360 chr15:41631175 T/A cg18705301 chr15:41695430 NDUFAF1 -1.06 -15.64 -0.69 1.7e-39 Ulcerative colitis; CESC cis rs10178094 0.933 rs10172311 chr2:161329365 C/T cg03641300 chr2:160917029 PLA2R1 0.37 5.35 0.31 1.86e-7 White blood cell count; CESC cis rs3806843 0.766 rs801176 chr5:140087010 A/G cg26395211 chr5:140044315 WDR55 -0.47 -6.09 -0.35 4.03e-9 Depressive symptoms (multi-trait analysis); CESC cis rs6952808 0.931 rs12537479 chr7:1868995 A/G cg13880726 chr7:1868755 MAD1L1 -0.52 -7.03 -0.4 1.77e-11 Bipolar disorder and schizophrenia; CESC cis rs7219021 1.000 rs2032843 chr17:46847524 T/A cg16584676 chr17:46985605 UBE2Z -0.7 -7.81 -0.43 1.37e-13 Schizophrenia or bipolar disorder; CESC cis rs752010 0.806 rs943375 chr1:42092152 A/G cg06885757 chr1:42089581 HIVEP3 0.5 8.31 0.45 5.03e-15 Lupus nephritis in systemic lupus erythematosus; CESC cis rs807669 0.548 rs9605957 chr22:19187375 G/A cg17887427 chr22:19166691 SLC25A1 -0.44 -5.66 -0.33 4.01e-8 Metabolite levels; CESC cis rs2070488 0.965 rs13097628 chr3:38521156 T/C cg24069376 chr3:38537580 EXOG 0.48 8.8 0.48 1.81e-16 Electrocardiographic conduction measures; CESC cis rs11055008 0.935 rs10845601 chr12:12820134 A/G cg04607235 chr12:12878440 APOLD1 0.71 9.36 0.5 3.59e-18 Pulse pressure; CESC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg25036284 chr2:26402008 FAM59B -0.82 -9.33 -0.5 4.31e-18 Gut microbiome composition (summer); CESC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg26818010 chr10:134567672 INPP5A -0.91 -11.09 -0.56 1e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7116495 0.786 rs1573501 chr11:71735693 C/T cg26138937 chr11:71823887 C11orf51 -1.33 -7.85 -0.43 1.06e-13 Severe influenza A (H1N1) infection; CESC cis rs7084402 0.967 rs1649055 chr10:60320045 T/A cg07615347 chr10:60278583 BICC1 0.63 10.12 0.53 1.48e-20 Refractive error; CESC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg24101359 chr6:42928495 GNMT 0.55 7.88 0.44 8.68e-14 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.9 0.39 3.85e-11 Bipolar disorder; CESC cis rs7267979 0.966 rs2261784 chr20:25262396 G/C cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.13e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs477692 0.648 rs10829599 chr10:131321881 C/T cg05714579 chr10:131428358 MGMT 0.41 5.28 0.31 2.71e-7 Response to temozolomide; CESC cis rs6761276 0.674 rs3811056 chr2:113831183 T/C cg12858261 chr2:113808755 IL1F8 0.46 5.68 0.33 3.63e-8 Protein quantitative trait loci; CESC cis rs7605827 0.836 rs1549016 chr2:15616859 G/A cg19274914 chr2:15703543 NA 0.36 6.42 0.37 6.17e-10 Educational attainment (years of education); CESC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg18404041 chr3:52824283 ITIH1 -0.37 -6.06 -0.35 4.58e-9 Bipolar disorder; CESC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg16434002 chr17:42200994 HDAC5 0.37 5.03 0.3 9.18e-7 Total body bone mineral density; CESC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs763121 0.853 rs5750677 chr22:39147715 C/T cg06022373 chr22:39101656 GTPBP1 0.93 15.87 0.7 2.44e-40 Menopause (age at onset); CESC cis rs2243480 1.000 rs36033484 chr7:65390558 T/G cg25894440 chr7:65020034 NA -0.62 -5.16 -0.3 4.73e-7 Diabetic kidney disease; CESC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg12963246 chr6:28129442 ZNF389 0.38 5.55 0.32 6.82e-8 Parkinson's disease; CESC cis rs55788414 0.932 rs35424543 chr16:81181983 G/A cg06400318 chr16:81190750 PKD1L2 -0.61 -5.46 -0.32 1.1e-7 Left ventricular obstructive tract defect (maternal effect); CESC cis rs9346455 1.000 rs9346455 chr6:71991816 A/C cg27238071 chr6:71998145 OGFRL1 0.59 5.44 0.32 1.19e-7 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22783180 chr10:8091753 NA 0.57 6.56 0.37 2.81e-10 Gut microbiome composition (summer); CESC cis rs1670533 1.000 rs6839931 chr4:1053172 A/G cg27284194 chr4:1044797 NA 0.45 5.71 0.33 3.1e-8 Recombination rate (females); CESC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg27572855 chr1:25598939 RHD 0.43 7.24 0.41 4.99e-12 Erythrocyte sedimentation rate; CESC cis rs6783573 0.535 rs12637699 chr3:46628443 C/T cg27371741 chr3:46619158 LRRC2;TDGF1 -0.32 -5.03 -0.3 9.02e-7 Cerebrospinal fluid biomarker levels; CESC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg22549504 chr19:17448937 GTPBP3 0.49 5.44 0.32 1.24e-7 Systemic lupus erythematosus; CESC cis rs67311347 1.000 rs962847 chr3:40495156 A/G cg09455208 chr3:40491958 NA -0.48 -8.1 -0.45 2.05e-14 Renal cell carcinoma; CESC cis rs7267979 1.000 rs10966 chr20:25282944 A/G cg08601574 chr20:25228251 PYGB 0.39 5.59 0.32 5.56e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.37 -0.36 8.27e-10 Total body bone mineral density; CESC cis rs9911578 1.000 rs2567905 chr17:56782297 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.19 0.3 4.29e-7 Intelligence (multi-trait analysis); CESC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg04369109 chr6:150039330 LATS1 -0.39 -5.27 -0.31 2.82e-7 Lung cancer; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg16704476 chr12:107350911 C12orf23 -0.55 -7.74 -0.43 2.05e-13 Prostate cancer (SNP x SNP interaction); CESC trans rs35883536 1.000 rs1832123 chr1:101168196 A/G cg16931499 chr17:42786676 DBF4B 0.42 6.14 0.35 3e-9 Monocyte count; CESC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg03538708 chr1:25844672 NA -0.36 -5.47 -0.32 1.03e-7 Erythrocyte sedimentation rate; CESC cis rs1577917 0.958 rs13213551 chr6:86608701 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -5.5 -0.32 9.03e-8 Response to antipsychotic treatment; CESC cis rs4689388 0.890 rs4342257 chr4:6290037 G/C cg00701064 chr4:6280414 WFS1 0.72 12.78 0.62 1.92e-29 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs11864453 0.713 rs9926156 chr16:72142895 G/C cg01557791 chr16:72042693 DHODH -0.48 -6.29 -0.36 1.27e-9 Fibrinogen levels; CESC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg09849774 chr21:43526787 UMODL1;C21orf128 -0.43 -5.11 -0.3 6.15e-7 IgG glycosylation; CESC trans rs163030 0.902 rs448293 chr5:76738927 A/C cg26150533 chr8:82396069 FABP4 -0.39 -6.01 -0.35 6.12e-9 Caudate nucleus volume; CESC cis rs7945705 0.935 rs11042102 chr11:8882164 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.35 5.64 0.33 4.29e-8 Hemoglobin concentration; CESC cis rs709400 0.628 rs11622356 chr14:103912195 C/T cg12935359 chr14:103987150 CKB -0.57 -8.42 -0.46 2.43e-15 Body mass index; CESC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg05368731 chr17:41323189 NBR1 0.79 11.25 0.57 3.01e-24 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22395253 chr7:104941898 SRPK2 0.5 6.4 0.37 7.05e-10 Fibrinogen levels; CESC cis rs11676348 0.846 rs7607437 chr2:219008392 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.45 -5.77 -0.33 2.26e-8 Ulcerative colitis; CESC cis rs11227306 0.934 rs2303385 chr11:65640562 G/A cg00576331 chr11:65640516 EFEMP2 0.47 6.08 0.35 4.1e-9 DNA methylation (variation); CESC cis rs7607369 0.782 rs639913 chr2:219365971 A/C cg02176678 chr2:219576539 TTLL4 0.5 9.05 0.49 3.15e-17 Red blood cell count;Amyotrophic lateral sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08579753 chr1:39174525 NA -0.64 -8.02 -0.44 3.36e-14 Gut microbiome composition (summer); CESC cis rs8067342 0.611 rs7213842 chr17:21175537 C/T cg03858720 chr17:21194718 MAP2K3 -0.38 -5.2 -0.3 3.89e-7 Immature fraction of reticulocytes;Red cell distribution width; CESC cis rs116095464 0.558 rs12173015 chr5:269967 A/C cg22857025 chr5:266934 NA 1.01 12.12 0.6 3.48e-27 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05182418 chr14:104176381 XRCC3 0.46 6.24 0.36 1.7e-9 Fibrinogen levels; CESC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg06221963 chr1:154839813 KCNN3 -0.66 -11.17 -0.57 5.33e-24 Prostate cancer; CESC cis rs1348850 0.668 rs13034886 chr2:178493301 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.08 0.3 7.12e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg18225595 chr11:63971243 STIP1 0.52 5.16 0.3 4.77e-7 Mean platelet volume; CESC cis rs6484504 0.532 rs11031342 chr11:31309818 G/A cg14844989 chr11:31128820 NA -0.4 -5.49 -0.32 9.59e-8 Red blood cell count; CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg17178900 chr1:205818956 PM20D1 0.87 15.49 0.69 5.76e-39 Menarche (age at onset); CESC cis rs9611565 0.694 rs5758324 chr22:41787950 G/T cg17376030 chr22:41985996 PMM1 0.43 5.16 0.3 4.84e-7 Vitiligo; CESC cis rs2228479 0.867 rs2270459 chr16:89979851 A/C cg04013166 chr16:89971882 TCF25 -0.68 -6.99 -0.39 2.24e-11 Skin colour saturation; CESC cis rs6866344 0.570 rs6896799 chr5:178147014 G/C cg10224037 chr5:178157518 ZNF354A 0.73 8.49 0.46 1.53e-15 Neutrophil percentage of white cells; CESC cis rs2625529 0.526 rs55763892 chr15:72540180 C/T cg16672083 chr15:72433130 SENP8 0.4 5.89 0.34 1.14e-8 Red blood cell count; CESC cis rs1707322 0.896 rs946528 chr1:46485562 C/T cg05343316 chr1:45956843 TESK2 -0.41 -5.05 -0.3 8.14e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14308291 chr1:36396265 EIF2C3 -0.49 -6.62 -0.38 1.95e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg11644478 chr21:40555479 PSMG1 0.82 12.48 0.61 1.94e-28 Cognitive function; CESC trans rs7937682 0.774 rs59921976 chr11:111473088 G/A cg18187862 chr3:45730750 SACM1L 0.48 6.01 0.35 5.97e-9 Primary sclerosing cholangitis; CESC cis rs12220238 0.908 rs10824077 chr10:75887038 C/T cg19889307 chr10:75911429 ADK;AP3M1 -0.63 -6.29 -0.36 1.33e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs7680126 0.671 rs7663044 chr4:10023939 C/G cg00071950 chr4:10020882 SLC2A9 0.54 5.15 0.3 5.07e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg06221963 chr1:154839813 KCNN3 -0.67 -11.23 -0.57 3.35e-24 Prostate cancer; CESC cis rs763121 0.853 rs5757208 chr22:39049230 A/C cg06544989 chr22:39130855 UNC84B 0.49 8.52 0.46 1.22e-15 Menopause (age at onset); CESC cis rs9831754 1.000 rs112170848 chr3:78359996 G/A cg06138941 chr3:78371609 NA -0.75 -8.54 -0.46 1.09e-15 Calcium levels; CESC cis rs644799 1.000 rs543530 chr11:95545170 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7100689 0.784 rs3120977 chr10:82075324 C/G cg09936400 chr10:82049201 MAT1A 0.37 5.26 0.31 2.93e-7 Post bronchodilator FEV1; CESC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.14e-7 Aortic root size; CESC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg25204440 chr1:209979598 IRF6 0.62 8.03 0.44 3.12e-14 Cleft lip with or without cleft palate; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15344021 chr17:2240169 TSR1;SGSM2 0.49 6.19 0.36 2.3e-9 Gut microbiota (bacterial taxa); CESC cis rs7178572 0.568 rs1389436 chr15:77665848 G/T cg22256960 chr15:77711686 NA -0.53 -6.77 -0.38 8.05e-11 Type 2 diabetes; CESC cis rs9303401 0.659 rs35828828 chr17:56718205 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.07 0.63 1.81e-30 Cognitive test performance; CESC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg00149659 chr3:10157352 C3orf10 0.71 8.76 0.47 2.39e-16 Alzheimer's disease; CESC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg13607699 chr17:42295918 UBTF 0.58 7.54 0.42 7.45e-13 Total body bone mineral density; CESC cis rs12579753 0.917 rs10862361 chr12:82197946 T/C cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs798554 0.610 rs2644304 chr7:2878779 T/C cg13628971 chr7:2884303 GNA12 0.4 5.34 0.31 2.01e-7 Height; CESC cis rs8114671 0.869 rs1544047 chr20:33670753 T/C cg06115741 chr20:33292138 TP53INP2 -0.44 -5.31 -0.31 2.27e-7 Height; CESC cis rs7267979 1.000 rs2257809 chr20:25266476 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9399135 0.935 rs11754504 chr6:135321509 C/T cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs965469 0.652 rs6051837 chr20:3388994 G/T cg25506879 chr20:3388711 C20orf194 -0.53 -6.17 -0.35 2.56e-9 IFN-related cytopenia; CESC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg07648498 chr16:89883185 FANCA 0.43 5.18 0.3 4.37e-7 Vitiligo; CESC cis rs4764487 0.760 rs733700 chr12:6337974 A/G cg08284733 chr12:6341482 CD9 0.37 5.47 0.32 1.02e-7 Mean platelet volume; CESC cis rs1799949 0.965 rs4793237 chr17:41436595 A/T cg05368731 chr17:41323189 NBR1 0.54 7.3 0.41 3.3e-12 Menopause (age at onset); CESC trans rs4919087 1.000 rs7067835 chr10:99074649 T/C cg09150807 chr12:131568764 GPR133 -0.37 -6.07 -0.35 4.41e-9 Monocyte count; CESC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg14159672 chr1:205819179 PM20D1 0.79 12.21 0.6 1.62e-27 Menarche (age at onset); CESC cis rs6570726 1.000 rs404229 chr6:145868200 G/A cg05347473 chr6:146136440 FBXO30 0.43 5.79 0.34 2e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1448094 0.817 rs10863111 chr12:86330615 T/C cg02569458 chr12:86230093 RASSF9 0.45 6.43 0.37 5.79e-10 Major depressive disorder; CESC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg10862848 chr6:42927986 GNMT -0.29 -7.4 -0.41 1.78e-12 Alzheimer's disease in APOE e4+ carriers; CESC cis rs3733585 0.775 rs13124007 chr4:10043931 G/C cg11266682 chr4:10021025 SLC2A9 0.65 12.28 0.6 9.55e-28 Cleft plate (environmental tobacco smoke interaction); CESC trans rs62103177 0.810 rs62103175 chr18:77622467 C/T cg05926928 chr17:57297772 GDPD1 1.19 10.32 0.54 3.18e-21 Opioid sensitivity; CESC cis rs1371867 0.846 rs1660324 chr8:101281271 C/T cg11906718 chr8:101322791 RNF19A 0.5 6.43 0.37 5.77e-10 Atrioventricular conduction; CESC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg16405210 chr4:1374714 KIAA1530 -0.95 -12.51 -0.61 1.51e-28 Longevity; CESC cis rs68170813 0.559 rs77727587 chr7:106815754 C/G cg02696742 chr7:106810147 HBP1 -0.55 -5.32 -0.31 2.24e-7 Coronary artery disease; CESC cis rs9324022 0.860 rs72698720 chr14:101178715 C/G cg18089426 chr14:101175970 NA 0.61 7.68 0.43 3.05e-13 Plateletcrit; CESC cis rs9291683 0.546 rs13129453 chr4:10044784 T/C cg11266682 chr4:10021025 SLC2A9 0.65 12.28 0.6 9.55e-28 Bone mineral density; CESC cis rs116095464 0.558 rs2162870 chr5:228129 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.69 0.33 3.34e-8 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09662431 chr10:73975914 ASCC1;C10orf104 -0.51 -7.6 -0.42 5.19e-13 Gambling; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25759457 chr1:172502420 C1orf9 0.45 6.24 0.36 1.7e-9 Systemic lupus erythematosus; CESC cis rs7647973 0.925 rs6446257 chr3:49253492 A/G cg13072238 chr3:49761600 GMPPB 0.41 5.1 0.3 6.35e-7 Menarche (age at onset); CESC cis rs6540556 0.723 rs1000283 chr1:209894661 A/G cg05527609 chr1:210001259 C1orf107 0.63 7.01 0.4 1.97e-11 Red blood cell count; CESC cis rs2412208 0.545 rs7414485 chr1:7121397 G/A cg20434152 chr1:7120926 CAMTA1 -0.36 -5.73 -0.33 2.7e-8 Survival in sporadic amyotrophic lateral sclerosis; CESC cis rs6424115 0.830 rs2503000 chr1:24197898 C/G cg15997130 chr1:24165203 NA 0.38 5.11 0.3 6.3e-7 Immature fraction of reticulocytes; CESC cis rs7927771 0.864 rs3781627 chr11:47441472 T/A cg05585544 chr11:47624801 NA 0.44 6.3 0.36 1.22e-9 Subjective well-being; CESC cis rs4975616 0.869 rs421284 chr5:1325590 T/C cg07493874 chr5:1342172 CLPTM1L -0.42 -7.98 -0.44 4.32e-14 Lung cancer; CESC cis rs2361718 0.500 rs8068856 chr17:78100731 A/G cg23534315 chr17:78082725 GAA 0.37 5.21 0.3 3.75e-7 Yeast infection; CESC cis rs10838687 0.800 rs2290146 chr11:47353498 G/A cg25783544 chr11:47291846 MADD 0.56 6.45 0.37 5.33e-10 Proinsulin levels; CESC cis rs6519955 0.866 rs9626920 chr22:46428993 A/G cg05468064 chr22:46423449 NA -0.4 -6.44 -0.37 5.68e-10 Dupuytren's disease; CESC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg14926445 chr8:58193284 C8orf71 -0.54 -5.28 -0.31 2.75e-7 Developmental language disorder (linguistic errors); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05893876 chr8:120428507 NOV -0.45 -6.24 -0.36 1.71e-9 Fibrinogen levels; CESC cis rs1971256 0.500 rs17081284 chr6:151800796 C/G cg10883421 chr6:151773342 RMND1;C6orf211 0.62 5.67 0.33 3.82e-8 Endometriosis; CESC cis rs7927592 0.956 rs7102273 chr11:68385579 T/C cg20283391 chr11:68216788 NA -0.48 -5.8 -0.34 1.88e-8 Total body bone mineral density; CESC cis rs1499614 0.901 rs2178742 chr7:66197799 G/A cg18252515 chr7:66147081 NA -1.42 -14.62 -0.67 6.69e-36 Gout; CESC cis rs854765 0.618 rs9908017 chr17:17774422 C/T cg09796270 chr17:17721594 SREBF1 -0.42 -5.97 -0.34 7.74e-9 Total body bone mineral density; CESC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.4 -5.1 -0.3 6.52e-7 Bipolar disorder; CESC cis rs7017914 0.967 rs10089583 chr8:71849484 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.18 -0.3 4.4e-7 Bone mineral density; CESC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg05368731 chr17:41323189 NBR1 0.57 7.82 0.43 1.24e-13 Menopause (age at onset); CESC cis rs2295499 0.639 rs7681728 chr4:2680515 A/G cg27239842 chr4:2403781 ZFYVE28 -0.32 -5.27 -0.31 2.85e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs2760061 0.599 rs849903 chr1:228137659 T/C cg02753203 chr1:228287806 NA -0.47 -6.68 -0.38 1.38e-10 Diastolic blood pressure; CESC cis rs1348850 0.526 rs10930797 chr2:178437553 C/G cg22681709 chr2:178499509 PDE11A -0.49 -5.12 -0.3 6.02e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs17095355 0.901 rs7069128 chr10:111760075 C/T cg00817464 chr10:111662876 XPNPEP1 0.51 5.98 0.34 7.22e-9 Biliary atresia; CESC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg02038168 chr22:39784481 NA -0.64 -7.49 -0.42 1e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg06494592 chr3:125709126 NA -0.51 -5.51 -0.32 8.32e-8 Blood pressure (smoking interaction); CESC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg22508957 chr16:3507546 NAT15 -0.68 -7.23 -0.41 5.11e-12 Tuberculosis; CESC cis rs722599 0.748 rs7145173 chr14:75351647 G/A cg08847533 chr14:75593920 NEK9 -0.45 -5.51 -0.32 8.52e-8 IgG glycosylation; CESC cis rs208520 0.690 rs1318604 chr6:66825278 A/C cg07460842 chr6:66804631 NA -1.01 -13.46 -0.64 8.19e-32 Exhaled nitric oxide output; CESC cis rs9611565 0.559 rs4822049 chr22:41993496 G/A cg06481639 chr22:41940642 POLR3H -0.65 -6.38 -0.37 7.65e-10 Vitiligo; CESC cis rs921968 0.565 rs6761437 chr2:219598092 G/A cg02176678 chr2:219576539 TTLL4 -0.45 -8.04 -0.44 2.97e-14 Mean corpuscular hemoglobin concentration; CESC cis rs10129255 0.500 rs11628999 chr14:107208446 C/T cg07958169 chr14:107095056 NA -0.53 -8.17 -0.45 1.23e-14 Kawasaki disease; CESC cis rs10089 0.953 rs6879970 chr5:127387178 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.77 10.06 0.53 2.19e-20 Ileal carcinoids; CESC cis rs5769707 0.933 rs2157444 chr22:49994292 A/G cg20744362 chr22:50050164 C22orf34 0.42 6.96 0.39 2.75e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs9309473 0.519 rs2421586 chr2:73899719 C/T cg20560298 chr2:73613845 ALMS1 0.53 7.32 0.41 3.04e-12 Metabolite levels; CESC trans rs9329221 0.537 rs6601414 chr8:9976748 G/A cg06636001 chr8:8085503 FLJ10661 0.49 6.29 0.36 1.28e-9 Neuroticism; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17774058 chr20:6748719 BMP2 0.42 6.2 0.36 2.14e-9 Systemic lupus erythematosus; CESC cis rs7957197 0.938 rs34565150 chr12:121429901 A/G cg12635120 chr12:121345228 NA -0.36 -5.15 -0.3 5.03e-7 Type 2 diabetes; CESC cis rs2549003 1.000 rs3846732 chr5:131816087 T/C cg21138405 chr5:131827807 IRF1 0.54 9.24 0.49 8.61e-18 Asthma (sex interaction); CESC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs868036 1.000 rs1026735 chr15:68101700 A/G cg08079166 chr15:68083412 MAP2K5 0.44 6.94 0.39 2.94e-11 Restless legs syndrome; CESC cis rs8040855 0.575 rs12912860 chr15:85573498 T/C cg08123816 chr15:85640762 PDE8A -0.39 -5.81 -0.34 1.79e-8 Bulimia nervosa; CESC cis rs8077889 0.672 rs15359 chr17:41843979 C/G cg26893861 chr17:41843967 DUSP3 -1.08 -22.44 -0.81 3.23e-63 Triglycerides; CESC cis rs763014 0.898 rs8050792 chr16:656033 T/C cg07343612 chr16:622815 PIGQ -0.54 -8.05 -0.44 2.86e-14 Height; CESC cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.36 0.6 5.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs8141529 0.719 rs132561 chr22:29351179 C/T cg02153584 chr22:29168773 CCDC117 -0.46 -5.73 -0.33 2.7e-8 Lymphocyte counts; CESC cis rs26868 0.766 rs30995 chr16:2248017 C/T cg02248941 chr16:2239361 CASKIN1 -0.38 -6.21 -0.36 2.04e-9 Height; CESC cis rs9467711 0.606 rs9393711 chr6:26370659 C/T cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg05564831 chr3:52568323 NT5DC2 0.46 7.33 0.41 2.88e-12 Bipolar disorder; CESC cis rs67311347 1.000 rs17078941 chr3:40450888 A/G cg09455208 chr3:40491958 NA -0.49 -8.01 -0.44 3.57e-14 Renal cell carcinoma; CESC cis rs807669 0.505 rs2236759 chr22:19187427 C/G cg17887427 chr22:19166691 SLC25A1 -0.39 -5.24 -0.31 3.29e-7 Metabolite levels; CESC trans rs117004340 0.687 rs73203975 chr8:13213016 C/T cg13468214 chr4:1046988 NA 0.66 6.52 0.37 3.6e-10 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs7927592 0.763 rs10896326 chr11:68234571 T/C cg16797656 chr11:68205561 LRP5 0.48 7.29 0.41 3.63e-12 Total body bone mineral density; CESC cis rs4141404 0.818 rs5997897 chr22:31570436 G/A cg02404636 chr22:31891804 SFI1 -0.38 -5.47 -0.32 1.03e-7 Paclitaxel-induced neuropathy; CESC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg22963979 chr7:1858916 MAD1L1 -0.38 -5.14 -0.3 5.29e-7 Bipolar disorder and schizophrenia; CESC cis rs738322 0.967 rs4385 chr22:38573229 T/C cg17652424 chr22:38574118 PLA2G6 -0.34 -6.07 -0.35 4.35e-9 Cutaneous nevi; CESC cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg01475377 chr6:109611718 NA -0.51 -8.38 -0.46 3.06e-15 Reticulocyte fraction of red cells; CESC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.71e-40 Aortic root size; CESC cis rs7264396 0.790 rs6579255 chr20:34219496 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 7.78 0.43 1.59e-13 Total cholesterol levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08240007 chr2:220407822 CHPF;TMEM198 -0.45 -6.0 -0.35 6.54e-9 Ulcerative colitis; CESC trans rs875971 1.000 rs6963646 chr7:65685767 T/C cg26939375 chr7:64535504 NA -0.46 -6.1 -0.35 3.8e-9 Aortic root size; CESC cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg01579765 chr21:45077557 HSF2BP -0.56 -9.35 -0.5 3.95e-18 Mean corpuscular volume; CESC cis rs9527 0.590 rs11191513 chr10:104772984 T/G cg08650961 chr10:104748594 CNNM2 0.31 5.03 0.3 9.04e-7 Arsenic metabolism; CESC trans rs4332037 0.539 rs4470910 chr7:2071723 C/T cg11693508 chr17:37793320 STARD3 0.66 6.68 0.38 1.43e-10 Bipolar disorder; CESC cis rs9894429 0.752 rs6565610 chr17:79592652 A/G cg21984481 chr17:79567631 NPLOC4 -0.56 -8.99 -0.48 4.98e-17 Eye color traits; CESC cis rs7296418 0.738 rs10846489 chr12:123743927 A/G cg00376283 chr12:123451042 ABCB9 -0.62 -8.59 -0.47 7.33e-16 Platelet count; CESC trans rs9951602 0.512 rs4798995 chr18:76654344 T/G cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg12386194 chr3:101231763 SENP7 0.43 5.35 0.31 1.92e-7 Colorectal cancer; CESC cis rs1801251 0.727 rs13029336 chr2:233569935 A/G cg25237894 chr2:233734115 C2orf82 -0.38 -6.64 -0.38 1.76e-10 Coronary artery disease; CESC cis rs963731 0.579 rs6739807 chr2:39287668 G/A cg04010122 chr2:39346883 SOS1 -0.64 -5.46 -0.32 1.07e-7 Corticobasal degeneration; CESC cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg00080972 chr5:178986291 RUFY1 0.38 5.72 0.33 2.89e-8 Lung cancer; CESC cis rs35110281 0.627 rs7283362 chr21:44973667 C/G cg04455712 chr21:45112962 RRP1B 0.38 5.66 0.33 4.03e-8 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16664859 chr1:226309452 NA 0.59 6.74 0.38 9.93e-11 Gut microbiome composition (summer); CESC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg00106254 chr7:1943704 MAD1L1 -0.45 -5.64 -0.33 4.46e-8 Bipolar disorder and schizophrenia; CESC cis rs7084402 0.967 rs1658495 chr10:60280153 C/A cg07615347 chr10:60278583 BICC1 -0.6 -9.67 -0.51 3.99e-19 Refractive error; CESC cis rs7267979 0.903 rs6132819 chr20:25218618 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.83 15.02 0.68 2.71e-37 Liver enzyme levels (alkaline phosphatase); CESC cis rs7624766 0.555 rs718757 chr3:160534225 A/G cg22637730 chr3:160473554 PPM1L -0.39 -5.09 -0.3 6.64e-7 Response to methotrexate in rheumatoid arthritis; CESC cis rs12701220 0.541 rs12535516 chr7:1114440 C/G cg26769984 chr7:1090371 C7orf50 0.54 5.72 0.33 2.85e-8 Bronchopulmonary dysplasia; CESC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg17372223 chr3:52568218 NT5DC2 0.44 6.53 0.37 3.36e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23954953 chr1:97187154 PTBP2 0.54 6.0 0.35 6.33e-9 Gut microbiome composition (summer); CESC cis rs911555 0.723 rs7149767 chr14:103863545 G/A cg24130564 chr14:104152367 KLC1 0.45 5.91 0.34 1.03e-8 Intelligence (multi-trait analysis); CESC cis rs9796 0.689 rs692511 chr15:41446252 A/C cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.33 -0.36 1.05e-9 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26998856 chr6:35227515 ZNF76 0.64 7.47 0.42 1.16e-12 Gut microbiome composition (summer); CESC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg25036284 chr2:26402008 FAM59B 0.65 7.73 0.43 2.24e-13 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg07677032 chr17:61819896 STRADA 0.45 6.05 0.35 5.02e-9 Prudent dietary pattern; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26820199 chr1:151372228 PSMB4 -0.54 -6.34 -0.36 1.01e-9 Ulcerative colitis; CESC cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg24308560 chr3:49941425 MST1R -0.64 -9.83 -0.52 1.17e-19 Intelligence (multi-trait analysis); CESC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg15787769 chr11:842744 TSPAN4;POLR2L -0.67 -8.45 -0.46 1.96e-15 Mean platelet volume; CESC cis rs116095464 1.000 rs56700778 chr5:313186 A/T cg22857025 chr5:266934 NA -1.24 -7.67 -0.43 3.29e-13 Breast cancer; CESC cis rs7542091 0.666 rs7537070 chr1:210043565 A/G cg21951975 chr1:209979733 IRF6 0.47 8.25 0.45 7.51e-15 Monobrow; CESC cis rs1790761 0.505 rs7945035 chr11:67348162 A/G cg14500267 chr11:67383377 NA -0.31 -5.12 -0.3 5.81e-7 Mean corpuscular volume; CESC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg08392591 chr16:89556376 ANKRD11 0.6 8.13 0.45 1.64e-14 Multiple myeloma (IgH translocation); CESC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.23 -0.36 1.86e-9 Schizophrenia; CESC cis rs1062177 0.694 rs2915816 chr5:151115857 G/A cg00977110 chr5:151150581 G3BP1 -0.53 -5.81 -0.34 1.74e-8 Preschool internalizing problems; CESC cis rs6714710 0.580 rs57681139 chr2:98454473 C/T cg26665480 chr2:98280029 ACTR1B 0.57 8.02 0.44 3.49e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs933688 0.938 rs10063683 chr5:90714595 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 12.45 0.61 2.47e-28 Smoking behavior; CESC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg04944784 chr2:26401820 FAM59B -0.56 -6.25 -0.36 1.61e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs2265474 chr6:146182092 G/A cg05347473 chr6:146136440 FBXO30 0.59 7.5 0.42 9.88e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs1707322 0.721 rs4660883 chr1:46236098 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.5 0.42 9.83e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12545109 0.800 rs1992122 chr8:57409467 A/G cg09654669 chr8:57350985 NA -0.47 -6.48 -0.37 4.37e-10 Obesity-related traits; CESC cis rs2228479 0.850 rs62054640 chr16:89823157 C/T cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs6032067 0.632 rs62208389 chr20:43794783 A/T cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs11690935 0.959 rs12692974 chr2:172663256 T/C cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.68 -0.67 4.14e-36 Schizophrenia; CESC trans rs9467711 0.524 rs13216484 chr6:26762087 C/T cg06606381 chr12:133084897 FBRSL1 -0.94 -7.65 -0.43 3.72e-13 Autism spectrum disorder or schizophrenia; CESC cis rs765787 0.530 rs11854689 chr15:45516052 A/G cg24006582 chr15:45444508 DUOX1 -0.58 -7.12 -0.4 1.04e-11 Uric acid levels; CESC cis rs854765 0.618 rs8068820 chr17:17834119 A/G cg16928487 chr17:17741425 SREBF1 -0.57 -9.74 -0.51 2.33e-19 Total body bone mineral density; CESC cis rs6121246 0.954 rs6060978 chr20:30416893 G/A cg13852791 chr20:30311386 BCL2L1 0.76 7.78 0.43 1.6e-13 Mean corpuscular hemoglobin; CESC trans rs2207136 0.804 rs1178066 chr6:50895795 G/A cg06522515 chr3:184090630 THPO -0.35 -6.06 -0.35 4.68e-9 Myopia; CESC cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg06550200 chr5:1325588 CLPTM1L -0.68 -10.29 -0.53 4.22e-21 Lung cancer; CESC cis rs7726839 0.540 rs72703080 chr5:595238 A/G cg16447950 chr5:562315 NA -0.55 -5.16 -0.3 4.75e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26877198 chr19:9938416 UBL5 0.59 7.0 0.4 2.1e-11 Gut microbiome composition (summer); CESC cis rs644799 0.735 rs10831432 chr11:95516040 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.75 11.15 0.57 6.1e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs17039065 0.920 rs7672020 chr4:109436064 T/C cg27151770 chr16:49620536 ZNF423 -0.51 -6.21 -0.36 2.09e-9 Gut microbiome composition (summer); CESC cis rs12893668 0.644 rs12890820 chr14:104034849 T/C cg24130564 chr14:104152367 KLC1 -0.5 -6.22 -0.36 1.93e-9 Reticulocyte count; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg05699592 chr3:48885332 PRKAR2A 0.45 6.17 0.35 2.5e-9 Thyroid stimulating hormone; CESC cis rs1348850 0.567 rs880897 chr2:178532503 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 6.95 0.39 2.92e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg18180107 chr4:99064573 C4orf37 0.39 5.07 0.3 7.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs17401966 1.000 rs12402052 chr1:10318652 C/G cg15208524 chr1:10270712 KIF1B 0.5 6.47 0.37 4.65e-10 Hepatocellular carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17235505 chr3:9439402 SETD5;LOC440944 -0.56 -6.26 -0.36 1.57e-9 Gut microbiome composition (summer); CESC cis rs8072100 0.790 rs6505048 chr17:45674998 G/A cg08085267 chr17:45401833 C17orf57 0.49 6.04 0.35 5.17e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg02569458 chr12:86230093 RASSF9 0.57 8.38 0.46 3.07e-15 Major depressive disorder; CESC cis rs5769707 0.681 rs9616329 chr22:50026314 G/A cg20744362 chr22:50050164 C22orf34 0.39 5.93 0.34 9.58e-9 Monocyte count;Monocyte percentage of white cells; CESC cis rs7584330 0.740 rs12471291 chr2:238441751 T/G cg14458575 chr2:238380390 NA 0.5 7.14 0.4 8.85e-12 Prostate cancer; CESC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.61 7.68 0.43 3.08e-13 Prudent dietary pattern; CESC cis rs916888 0.773 rs538628 chr17:44787313 G/C cg01570182 chr17:44337453 NA 0.9 10.23 0.53 6.61e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05808815 chr1:54666250 CYB5RL;MRPL37 0.49 6.11 0.35 3.49e-9 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs4660906 chr1:46470860 C/T cg03146154 chr1:46216737 IPP 0.69 9.24 0.49 8.15e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10242455 0.867 rs1879859 chr7:99294762 C/T cg07715041 chr7:99302981 CYP3A7 -0.44 -5.56 -0.32 6.73e-8 Blood metabolite levels; CESC cis rs17039065 0.920 rs17039063 chr4:109381134 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.6 5.06 0.3 8.01e-7 Gut microbiome composition (summer); CESC cis rs9611565 0.506 rs2024566 chr22:41697338 A/G cg03806693 chr22:41940476 POLR3H -0.76 -8.65 -0.47 5.19e-16 Vitiligo; CESC cis rs10751667 0.643 rs7395613 chr11:933873 C/T cg06064525 chr11:970664 AP2A2 -0.52 -10.37 -0.54 2.34e-21 Alzheimer's disease (late onset); CESC cis rs67311347 1.000 rs12634013 chr3:40452388 T/C cg09455208 chr3:40491958 NA 0.53 8.72 0.47 3.11e-16 Renal cell carcinoma; CESC cis rs3862260 0.509 rs3862262 chr1:120161841 G/T cg11530693 chr1:120165357 ZNF697 0.7 10.91 0.56 4.03e-23 Systemic lupus erythematosus; CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg11905131 chr22:24372483 LOC391322 -0.7 -10.04 -0.52 2.62e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6430585 0.528 rs10496738 chr2:136751488 C/T cg07169764 chr2:136633963 MCM6 1.27 17.1 0.72 1.1e-44 Corneal structure; CESC cis rs7523050 0.643 rs12741359 chr1:109400489 T/C cg08274380 chr1:109419600 GPSM2 0.83 5.58 0.32 5.89e-8 Fat distribution (HIV); CESC cis rs2573652 1.000 rs2581345 chr15:100514291 A/G cg09918751 chr15:100517450 ADAMTS17 -0.4 -7.86 -0.43 9.74e-14 Height; CESC cis rs1691799 0.899 rs1168322 chr12:66743769 C/T cg16791601 chr12:66731901 HELB -0.79 -14.55 -0.67 1.18e-35 White blood cell count (basophil); CESC trans rs7947523 0.813 rs4999940 chr11:80942337 C/T cg21800906 chr11:32914818 QSER1 0.46 6.07 0.35 4.48e-9 Emphysema imaging phenotypes; CESC cis rs911555 0.723 rs4906320 chr14:103876925 T/C cg24130564 chr14:104152367 KLC1 0.46 5.96 0.34 8.04e-9 Intelligence (multi-trait analysis); CESC cis rs7795096 0.532 rs7812239 chr7:151546806 C/G cg17008978 chr7:151542804 PRKAG2 0.35 5.53 0.32 7.66e-8 Bipolar disorder (age of onset and psychotic symptoms); CESC cis rs1801251 1.000 rs283471 chr2:233656627 G/A cg08000102 chr2:233561755 GIGYF2 0.69 9.79 0.52 1.58e-19 Coronary artery disease; CESC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg11494091 chr17:61959527 GH2 0.73 12.56 0.61 1.09e-28 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13725913 chr9:140675929 EHMT1 -0.51 -6.02 -0.35 5.87e-9 Gut microbiome composition (summer); CESC cis rs1008375 0.900 rs13144986 chr4:17675019 C/A cg02297831 chr4:17616191 MED28 -0.56 -6.3 -0.36 1.21e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.04 -0.56 1.41e-23 Alzheimer's disease; CESC cis rs6912958 0.712 rs2814712 chr6:88396322 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.36 5.77 0.33 2.19e-8 Monocyte percentage of white cells; CESC cis rs9457247 0.663 rs10946205 chr6:167451311 A/G cg23791538 chr6:167370224 RNASET2 -0.58 -7.85 -0.43 1e-13 Crohn's disease; CESC cis rs12477438 0.501 rs11685756 chr2:99766215 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.91 15.68 0.69 1.18e-39 Chronic sinus infection; CESC cis rs67311347 1.000 rs1454497 chr3:40496326 C/T cg24209194 chr3:40518798 ZNF619 -0.56 -7.45 -0.42 1.35e-12 Renal cell carcinoma; CESC cis rs992157 0.798 rs10206064 chr2:219157959 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.02 0.48 3.81e-17 Colorectal cancer; CESC cis rs17376456 0.877 rs10476526 chr5:93461916 G/A cg21475434 chr5:93447410 FAM172A 0.82 7.56 0.42 6.81e-13 Diabetic retinopathy; CESC cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg05347473 chr6:146136440 FBXO30 0.55 7.26 0.41 4.4e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg22920501 chr2:26401640 FAM59B -0.71 -7.87 -0.44 9.22e-14 Gut microbiome composition (summer); CESC cis rs2880765 0.835 rs730372 chr15:86038193 G/T cg10818794 chr15:86012489 AKAP13 0.34 5.29 0.31 2.6e-7 Coronary artery disease; CESC cis rs738322 0.967 rs4380 chr22:38569529 T/C cg17652424 chr22:38574118 PLA2G6 -0.33 -5.93 -0.34 9.22e-9 Cutaneous nevi; CESC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg09877947 chr5:131593287 PDLIM4 0.47 6.13 0.35 3.2e-9 Breast cancer; CESC cis rs2797160 0.651 rs6569436 chr6:126032104 A/G cg05901451 chr6:126070800 HEY2 0.5 7.25 0.41 4.61e-12 Endometrial cancer; CESC cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg11752832 chr7:134001865 SLC35B4 0.54 7.02 0.4 1.88e-11 Mean platelet volume; CESC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg23048001 chr7:2026167 MAD1L1 0.43 5.57 0.32 6.1e-8 Bipolar disorder and schizophrenia; CESC cis rs4547160 0.962 rs7308703 chr12:63494993 C/T cg26727693 chr12:63544175 AVPR1A -0.42 -6.3 -0.36 1.21e-9 Morning vs. evening chronotype; CESC trans rs877282 0.583 rs12358255 chr10:828626 C/T cg22713356 chr15:30763199 NA 0.97 9.25 0.49 7.82e-18 Uric acid levels; CESC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg18904891 chr8:8559673 CLDN23 -0.73 -8.61 -0.47 6.67e-16 Obesity-related traits; CESC cis rs8114671 0.967 rs6142322 chr20:33788538 C/A cg06115741 chr20:33292138 TP53INP2 -0.42 -5.16 -0.3 4.74e-7 Height; CESC cis rs1808579 0.904 rs1788781 chr18:21165080 A/C cg14672496 chr18:21087552 C18orf8 -0.36 -5.32 -0.31 2.23e-7 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs8053891 0.756 rs9930930 chr16:72001971 A/G cg04254540 chr16:71951199 KIAA0174 -0.42 -5.4 -0.32 1.45e-7 Coronary artery disease; CESC cis rs3806843 1.000 rs10072015 chr5:140170655 A/T cg16179182 chr5:140090404 VTRNA1-1 0.4 5.15 0.3 5.05e-7 Depressive symptoms (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13920768 chr9:133557644 PRDM12 -0.39 -6.29 -0.36 1.31e-9 Gambling; CESC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg04234412 chr22:24373322 LOC391322 -0.5 -7.19 -0.4 6.66e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg00129232 chr17:37814104 STARD3 -0.57 -7.49 -0.42 1.02e-12 Glomerular filtration rate (creatinine); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27275677 chr13:115047248 UPF3A -0.44 -6.08 -0.35 4.26e-9 Fibrinogen levels; CESC cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg00255919 chr5:131827918 IRF1 0.51 8.68 0.47 4.19e-16 Asthma (sex interaction); CESC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg03609598 chr5:56110824 MAP3K1 -0.51 -5.42 -0.32 1.36e-7 Initial pursuit acceleration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07645736 chr6:137243249 SLC35D3 -0.52 -7.38 -0.41 2.02e-12 Gut microbiota (bacterial taxa); CESC cis rs4604732 0.536 rs4433437 chr1:247636580 A/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.45 5.71 0.33 3.08e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.85 8.83 0.48 1.5e-16 Platelet count; CESC cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg06212747 chr3:49208901 KLHDC8B 0.67 8.99 0.48 4.66e-17 Parkinson's disease; CESC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg12463550 chr7:65579703 CRCP -0.46 -5.86 -0.34 1.34e-8 Aortic root size; CESC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.28 0.31 2.75e-7 Menopause (age at onset); CESC cis rs9914988 0.943 rs9894335 chr17:27138483 C/A cg20469991 chr17:27169893 C17orf63 -0.47 -5.13 -0.3 5.5e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs2295359 0.892 rs11209004 chr1:67613932 G/A cg17031739 chr1:67600172 NA 0.4 5.27 0.31 2.88e-7 Psoriasis; CESC cis rs13034020 0.522 rs62150978 chr2:61256222 T/C cg18625361 chr2:61244694 PEX13;PUS10 0.66 6.41 0.37 6.45e-10 Hodgkin's lymphoma; CESC cis rs6964587 0.839 rs11767135 chr7:91551245 T/G cg17063962 chr7:91808500 NA -0.53 -7.09 -0.4 1.21e-11 Breast cancer; CESC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.69 -8.91 -0.48 8.69e-17 Mean platelet volume; CESC cis rs9393777 0.513 rs13210025 chr6:26654817 A/C cg12292205 chr6:26970375 C6orf41 -0.51 -5.49 -0.32 9.37e-8 Intelligence (multi-trait analysis); CESC cis rs7078219 0.505 rs41290504 chr10:101293035 C/A cg09788492 chr10:101292477 NKX2-3 0.32 5.99 0.35 6.65e-9 Dental caries; CESC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.51 0.37 3.76e-10 Bipolar disorder; CESC trans rs2727020 0.514 rs4980444 chr11:49550764 T/A cg03929089 chr4:120376271 NA -0.81 -12.24 -0.6 1.37e-27 Coronary artery disease; CESC cis rs926938 0.541 rs360623 chr1:115407268 G/C cg12756093 chr1:115239321 AMPD1 0.43 5.84 0.34 1.54e-8 Autism; CESC cis rs3820068 0.603 rs7537618 chr1:15977682 G/A cg13390004 chr1:15929781 NA 0.36 5.68 0.33 3.52e-8 Systolic blood pressure; CESC cis rs123509 0.687 rs73077208 chr3:42835205 G/A cg12982090 chr3:42733453 KBTBD5 -0.66 -7.52 -0.42 8.26e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1878931 0.582 rs9635562 chr16:3416689 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.73 9.25 0.49 7.99e-18 Body mass index (adult); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01830674 chr2:219433148 RQCD1;USP37 0.69 8.17 0.45 1.27e-14 Gut microbiome composition (summer); CESC cis rs74781061 0.929 rs6495118 chr15:74912012 T/G cg17294928 chr15:75287854 SCAMP5 -0.49 -5.2 -0.3 3.92e-7 Endometriosis; CESC cis rs28489187 0.683 rs6657817 chr1:85874614 C/T cg16011679 chr1:85725395 C1orf52 -0.46 -5.53 -0.32 7.8e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs2235642 0.893 rs2076442 chr16:1591112 G/T cg09080909 chr16:1797204 MAPK8IP3 -0.39 -5.26 -0.31 3.03e-7 Coronary artery disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19936194 chr3:141595256 ATP1B3 -0.5 -6.39 -0.37 7.53e-10 Ulcerative colitis; CESC trans rs7937682 0.924 rs11213968 chr11:111527629 G/C cg18187862 chr3:45730750 SACM1L 0.5 6.36 0.36 8.96e-10 Primary sclerosing cholangitis; CESC cis rs6694270 0.529 rs11261065 chr1:19106254 A/C cg19637330 chr1:19110922 NA -0.48 -5.91 -0.34 1.05e-8 Drug-induced liver injury (nitrofurantoin); CESC cis rs2204008 0.775 rs2387809 chr12:38363338 T/A cg26384229 chr12:38710491 ALG10B 0.73 10.95 0.56 2.81e-23 Bladder cancer; CESC cis rs9291683 0.632 rs10939669 chr4:10045827 A/G cg02734326 chr4:10020555 SLC2A9 0.47 6.6 0.38 2.23e-10 Bone mineral density; CESC cis rs9486715 0.867 rs4839834 chr6:96882109 C/A cg18709589 chr6:96969512 KIAA0776 0.45 6.29 0.36 1.31e-9 Headache; CESC cis rs11997175 0.846 rs6999445 chr8:33732693 G/A ch.8.33884649F chr8:33765107 NA 0.78 10.44 0.54 1.35e-21 Body mass index; CESC cis rs66569888 0.632 rs6728600 chr2:106898653 G/T cg16099169 chr2:106886729 NA -0.51 -5.42 -0.32 1.31e-7 Facial morphology (factor 23); CESC cis rs10883723 0.810 rs2296585 chr10:104245549 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.83 -0.34 1.57e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs637571 0.726 rs669371 chr11:65674153 G/T cg04055107 chr11:65626734 MUS81;CFL1 -0.67 -8.32 -0.46 4.59e-15 Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03831054 chr5:140768999 PCDHGB4;PCDHGA4;PCDHGA6;PCDHGA1;PCDHGA5;PCDHGB1;PCDHGA3;PCDHGA2;PCDHGA7;PCDHGB2;PCDHGB3 -0.54 -6.29 -0.36 1.33e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20697630 chr1:20960374 PINK1 0.55 6.17 0.35 2.59e-9 Gut microbiome composition (summer); CESC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg07507251 chr3:52567010 NT5DC2 0.32 5.73 0.33 2.66e-8 Electroencephalogram traits; CESC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.02e-11 Tonsillectomy; CESC cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg20503657 chr10:835505 NA 0.82 8.12 0.45 1.71e-14 Eosinophil percentage of granulocytes; CESC cis rs78456975 0.739 rs28913003 chr2:1519620 A/T cg01028140 chr2:1542097 TPO -0.47 -5.29 -0.31 2.56e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9303401 0.614 rs35057477 chr17:57097064 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.97 12.0 0.59 8.95e-27 Cognitive test performance; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01213651 chr5:165085761 NA -0.38 -6.29 -0.36 1.31e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11785400 1.000 rs6988393 chr8:143740596 A/G cg10596483 chr8:143751796 JRK 0.43 5.65 0.33 4.1e-8 Schizophrenia; CESC cis rs16854884 0.657 rs35085196 chr3:143712210 C/T cg06585982 chr3:143692056 C3orf58 0.52 6.71 0.38 1.15e-10 Economic and political preferences (feminism/equality); CESC cis rs9913156 0.793 rs4346260 chr17:4567215 A/G cg00122941 chr17:4613640 ARRB2 -0.82 -9.66 -0.51 4.06e-19 Lymphocyte counts; CESC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.27 0.31 2.76e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg05585544 chr11:47624801 NA -0.48 -7.04 -0.4 1.67e-11 Subjective well-being; CESC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.42e-7 Lung cancer; CESC cis rs35306767 0.714 rs10508206 chr10:1075777 A/C cg26597838 chr10:835615 NA 0.57 6.0 0.35 6.44e-9 Eosinophil percentage of granulocytes; CESC cis rs1451375 0.617 rs10277662 chr7:50594836 C/T cg14593290 chr7:50529359 DDC 0.49 5.99 0.35 6.77e-9 Malaria; CESC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg07677032 chr17:61819896 STRADA 0.44 5.81 0.34 1.78e-8 Prudent dietary pattern; CESC cis rs6750795 0.569 rs1797387 chr2:232414692 A/G cg19187155 chr2:232395269 NMUR1 0.66 11.53 0.58 3.27e-25 Height; CESC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg19318889 chr4:1322082 MAEA 0.56 6.79 0.39 7.23e-11 Longevity; CESC cis rs35123781 1.000 rs599946 chr5:139057461 A/G cg10513866 chr5:139070639 NA 0.37 5.37 0.31 1.75e-7 Schizophrenia; CESC cis rs4268898 1.000 rs10195436 chr2:24436112 C/T cg06627628 chr2:24431161 ITSN2 0.62 7.32 0.41 2.89e-12 Asthma; CESC cis rs9399137 0.507 rs61738647 chr6:135282735 T/C cg22676075 chr6:135203613 NA 0.51 6.61 0.38 2.1e-10 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs6987853 0.933 rs1343875 chr8:42424749 C/T cg09913449 chr8:42400586 C8orf40 0.41 6.53 0.37 3.25e-10 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20703731 chr5:55237351 IL6ST -0.55 -6.66 -0.38 1.61e-10 Gut microbiome composition (summer); CESC cis rs6547741 0.874 rs58737572 chr2:27852118 A/C cg27432699 chr2:27873401 GPN1 0.5 7.03 0.4 1.74e-11 Oral cavity cancer; CESC cis rs2637266 0.846 rs2579773 chr10:78402847 A/C cg18941641 chr10:78392320 NA 0.41 7.52 0.42 8.34e-13 Pulmonary function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13114696 chr21:47808953 PCNT 0.44 6.14 0.35 3.03e-9 Fibrinogen levels; CESC cis rs2249625 0.523 rs2496501 chr6:72885364 A/G cg18830697 chr6:72922368 RIMS1 -0.47 -6.88 -0.39 4.4e-11 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC trans rs459571 0.715 rs401826 chr9:136890591 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.65 -8.31 -0.45 5.09e-15 Platelet distribution width; CESC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg23758822 chr17:41437982 NA 1.01 15.2 0.68 5.81e-38 Menopause (age at onset); CESC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg24550644 chr17:30846204 MYO1D 0.43 6.53 0.37 3.3e-10 Schizophrenia; CESC cis rs62103177 0.535 rs4799109 chr18:77675188 A/T cg12964065 chr18:77638022 KCNG2 0.51 5.33 0.31 2.08e-7 Opioid sensitivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16480132 chr7:149571111 LOC401431;ATP6V0E2 0.53 6.04 0.35 5.25e-9 Gut microbiome composition (summer); CESC cis rs2797160 0.967 rs2747718 chr6:126009109 C/A cg05901451 chr6:126070800 HEY2 0.45 6.59 0.38 2.39e-10 Endometrial cancer; CESC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs6732160 0.549 rs6744529 chr2:73480869 A/G cg01422370 chr2:73384389 NA 0.42 7.12 0.4 1.03e-11 Intelligence (multi-trait analysis); CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg14159672 chr1:205819179 PM20D1 0.87 14.81 0.67 1.42e-36 Menarche (age at onset); CESC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.84e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg01097406 chr16:89675127 NA -0.33 -5.09 -0.3 6.91e-7 Vitiligo; CESC trans rs3942852 0.806 rs11039515 chr11:48119474 A/G cg15704280 chr7:45808275 SEPT13 0.63 7.37 0.41 2.12e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs7618501 1.000 rs6775384 chr3:49853073 G/A cg24308560 chr3:49941425 MST1R -0.52 -7.12 -0.4 1e-11 Intelligence (multi-trait analysis); CESC cis rs9787249 0.957 rs7548120 chr1:40204424 A/T cg19912559 chr1:40204330 PPIE 0.43 6.59 0.38 2.3e-10 Blood protein levels; CESC cis rs35110281 0.744 rs8131027 chr21:45104908 G/C cg01579765 chr21:45077557 HSF2BP -0.49 -8.26 -0.45 7.19e-15 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03789152 chr12:72233372 TBC1D15 0.65 7.56 0.42 6.69e-13 Gut microbiome composition (summer); CESC cis rs1801251 0.778 rs709933 chr2:233733144 G/A cg08000102 chr2:233561755 GIGYF2 -0.6 -8.17 -0.45 1.26e-14 Coronary artery disease; CESC cis rs1950626 0.577 rs35097045 chr14:101454403 G/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.67 8.97 0.48 5.38e-17 Pelvic organ prolapse (moderate/severe); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08523029 chr5:130500466 HINT1 0.61 6.84 0.39 5.54e-11 Gut microbiome composition (summer); CESC cis rs9611565 0.592 rs12484254 chr22:41962003 T/A cg06634786 chr22:41940651 POLR3H -0.62 -6.83 -0.39 5.85e-11 Vitiligo; CESC cis rs926938 0.520 rs2007231 chr1:115266306 C/T cg12756093 chr1:115239321 AMPD1 -0.54 -6.89 -0.39 4.02e-11 Autism; CESC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg25072359 chr17:41440525 NA 0.49 6.42 0.37 6.13e-10 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01831166 chr2:198570100 MARS2 0.59 6.24 0.36 1.74e-9 Gut microbiome composition (summer); CESC cis rs3820928 0.874 rs4675134 chr2:227843489 C/T cg11843606 chr2:227700838 RHBDD1 -0.5 -6.49 -0.37 4.27e-10 Pulmonary function; CESC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg06873352 chr17:61820015 STRADA 0.47 6.86 0.39 4.85e-11 Height; CESC cis rs1395 0.778 rs11693001 chr2:27412744 C/T cg22903471 chr2:27725779 GCKR -0.42 -5.21 -0.3 3.81e-7 Blood metabolite levels; CESC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.6 0.51 6.43e-19 Platelet count; CESC cis rs6500602 0.727 rs8051389 chr16:4570570 C/T cg08645402 chr16:4508243 NA 0.54 8.81 0.48 1.7e-16 Schizophrenia; CESC cis rs116095464 0.614 rs56299325 chr5:220594 C/T cg22857025 chr5:266934 NA -1.27 -18.89 -0.76 5.51e-51 Breast cancer; CESC cis rs7772486 0.686 rs9390357 chr6:146129347 A/G cg05347473 chr6:146136440 FBXO30 0.51 6.75 0.38 9.17e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs11864453 0.647 rs9932062 chr16:72136055 T/C cg16558253 chr16:72132732 DHX38 -0.54 -8.44 -0.46 2.04e-15 Fibrinogen levels; CESC cis rs1048257 0.553 rs2819421 chr14:105408811 A/G cg21017887 chr14:105400489 NA 0.42 6.79 0.38 7.31e-11 Systemic lupus erythematosus; CESC cis rs7395581 0.918 rs10742799 chr11:47293702 T/C cg25783544 chr11:47291846 MADD 0.62 8.26 0.45 6.99e-15 HDL cholesterol; CESC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.26 0.53 5.01e-21 Prudent dietary pattern; CESC cis rs8103278 0.507 rs62111759 chr19:46296230 A/T cg14061069 chr19:46274453 DMPK 0.55 8.65 0.47 4.93e-16 Coronary artery disease; CESC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg09491104 chr22:46646882 C22orf40 -0.51 -5.43 -0.32 1.25e-7 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg03452623 chr4:187889614 NA -0.85 -13.57 -0.64 3.32e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs9287719 0.934 rs12692418 chr2:10745870 T/C cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC cis rs7267979 0.816 rs6115094 chr20:25210827 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.73 12.63 0.61 5.88e-29 Liver enzyme levels (alkaline phosphatase); CESC cis rs2228479 0.850 rs62052714 chr16:89857180 T/C cg00800038 chr16:89945340 TCF25 -0.9 -7.5 -0.42 9.55e-13 Skin colour saturation; CESC cis rs10191773 0.522 rs6747639 chr2:112967458 C/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.69 -6.9 -0.39 3.75e-11 Yeast infection; CESC cis rs7923609 0.846 rs7098181 chr10:65027143 G/T cg01631684 chr10:65280961 REEP3 -0.44 -5.4 -0.31 1.51e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.86 0.34 1.37e-8 Tonsillectomy; CESC cis rs9790314 0.502 rs7647118 chr3:161016165 T/C cg03342759 chr3:160939853 NMD3 -0.52 -7.4 -0.41 1.76e-12 Morning vs. evening chronotype; CESC cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg02079420 chr8:82753780 SNX16 0.56 7.51 0.42 9.17e-13 Diastolic blood pressure; CESC cis rs2425143 1.000 rs11696947 chr20:34312658 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.29 0.31 2.61e-7 Blood protein levels; CESC cis rs7772486 0.875 rs10457792 chr6:146412415 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.51 0.37 3.83e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7143963 0.666 rs2092973 chr14:103320961 G/A cg24154132 chr14:103367632 TRAF3 0.36 6.54 0.37 3.23e-10 Body mass index; CESC cis rs4481887 0.790 rs4453078 chr1:248411889 A/G cg00666640 chr1:248458726 OR2T12 -0.3 -5.4 -0.31 1.49e-7 Common traits (Other); CESC trans rs875971 0.660 rs12698534 chr7:65986845 C/T cg26939375 chr7:64535504 NA 0.64 8.68 0.47 4.14e-16 Aortic root size; CESC cis rs2228479 0.557 rs2293584 chr16:89888686 C/G cg06558623 chr16:89946397 TCF25 1.12 8.24 0.45 7.86e-15 Skin colour saturation; CESC cis rs7927771 1.000 rs12361031 chr11:47783076 G/A cg18512352 chr11:47633146 NA -0.61 -9.64 -0.51 4.87e-19 Subjective well-being; CESC cis rs2197308 0.692 rs67352173 chr12:37906912 A/T cg13010199 chr12:38710504 ALG10B 0.46 5.78 0.33 2.05e-8 Morning vs. evening chronotype; CESC cis rs2243480 1.000 rs1796220 chr7:66062100 C/T cg18252515 chr7:66147081 NA -1.39 -14.25 -0.66 1.31e-34 Diabetic kidney disease; CESC cis rs9486719 1.000 rs11152969 chr6:96908712 A/C cg18709589 chr6:96969512 KIAA0776 -0.54 -5.97 -0.34 7.42e-9 Migraine;Coronary artery disease; CESC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.13 0.81 3.58e-62 Prudent dietary pattern; CESC cis rs2932538 0.922 rs999923 chr1:113110548 T/C cg22162597 chr1:113214053 CAPZA1 0.55 6.96 0.39 2.59e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg04369109 chr6:150039330 LATS1 -0.39 -5.34 -0.31 2.01e-7 Lung cancer; CESC cis rs6940638 0.688 rs9379960 chr6:27121325 A/C cg12826209 chr6:26865740 GUSBL1 0.41 5.41 0.32 1.39e-7 Intelligence (multi-trait analysis); CESC cis rs10088262 0.527 rs3911939 chr8:124793744 T/G cg20713898 chr8:124780851 FAM91A1 -0.67 -8.54 -0.46 1.06e-15 Pancreatic cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03705947 chr1:68152081 GADD45A 0.51 6.89 0.39 4.09e-11 Gut microbiota (bacterial taxa); CESC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg11890956 chr21:40555474 PSMG1 -0.69 -9.97 -0.52 4.48e-20 Menarche (age at onset); CESC cis rs703842 0.892 rs1021469 chr12:58208164 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.65 8.06 0.44 2.6e-14 Multiple sclerosis; CESC cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg10556349 chr10:835070 NA 0.54 5.16 0.3 4.75e-7 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05485520 chr3:45883628 LZTFL1 0.53 7.05 0.4 1.54e-11 Gut microbiota (bacterial taxa); CESC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs1728785 0.901 rs8050289 chr16:68566976 T/A cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg17372223 chr3:52568218 NT5DC2 0.45 6.61 0.38 2.14e-10 Bipolar disorder; CESC cis rs55871839 0.684 rs7829715 chr8:59803836 C/T cg07426533 chr8:59803705 TOX 0.5 7.14 0.4 9.01e-12 Pneumonia; CESC cis rs6463523 0.898 rs66892628 chr7:759374 T/A cg11064039 chr7:766100 PRKAR1B;HEATR2 1.0 15.85 0.7 3.03e-40 Subjective well-being; CESC cis rs17376456 0.877 rs9314095 chr5:93425495 T/C cg21475434 chr5:93447410 FAM172A 0.83 7.47 0.42 1.17e-12 Diabetic retinopathy; CESC cis rs938554 0.571 rs4144 chr4:10016322 T/C cg02734326 chr4:10020555 SLC2A9 0.51 5.71 0.33 2.97e-8 Blood metabolite levels; CESC cis rs2880765 0.835 rs6497202 chr15:86021375 T/C cg10818794 chr15:86012489 AKAP13 -0.34 -5.24 -0.31 3.32e-7 Coronary artery disease; CESC cis rs4727027 0.933 rs34578816 chr7:148847606 G/A cg23583168 chr7:148888333 NA -0.81 -12.62 -0.61 6.75e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7949030 0.588 rs2428549 chr11:62312394 A/G cg13298116 chr11:62369859 EML3;MTA2 0.57 8.57 0.47 8.49e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs66887589 0.870 rs2389875 chr4:120557014 G/T cg09307838 chr4:120376055 NA -0.47 -6.4 -0.37 6.86e-10 Diastolic blood pressure; CESC cis rs6570726 0.791 rs6570694 chr6:145911204 C/G cg05347473 chr6:146136440 FBXO30 0.57 7.44 0.42 1.37e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7520050 0.966 rs1707335 chr1:46571921 C/T cg24296786 chr1:45957014 TESK2 0.41 5.17 0.3 4.63e-7 Red blood cell count;Reticulocyte count; CESC cis rs921968 0.541 rs634590 chr2:219372768 C/A cg02176678 chr2:219576539 TTLL4 0.5 9.05 0.49 3.15e-17 Mean corpuscular hemoglobin concentration; CESC cis rs3947 0.906 rs1692821 chr8:11699988 C/T cg00262122 chr8:11665843 FDFT1 -0.49 -5.67 -0.33 3.79e-8 Blood protein levels; CESC cis rs6089584 0.545 rs6089578 chr20:60554636 G/T cg06108461 chr20:60628389 TAF4 -0.53 -6.91 -0.39 3.65e-11 Body mass index; CESC trans rs9914544 0.591 rs9900052 chr17:18699398 G/A cg04702396 chr17:15466718 FAM18B2 0.53 6.61 0.38 2.06e-10 Educational attainment (years of education); CESC cis rs4561483 0.603 rs11544193 chr16:12009304 C/A cg08843971 chr16:11963173 GSPT1 0.46 6.45 0.37 5.14e-10 Testicular germ cell tumor; CESC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs9486715 1.000 rs6905568 chr6:97066382 T/C cg18709589 chr6:96969512 KIAA0776 -0.46 -6.48 -0.37 4.56e-10 Headache; CESC cis rs7772486 0.875 rs9390377 chr6:146386932 G/A cg05347473 chr6:146136440 FBXO30 0.51 6.76 0.38 8.56e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00377757 chr17:76921538 TIMP2 0.56 6.52 0.37 3.52e-10 Gut microbiome composition (summer); CESC cis rs79349575 0.783 rs4793996 chr17:47019597 T/C cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs4132509 1.000 rs6660534 chr1:243791642 A/C cg21452805 chr1:244014465 NA 0.44 5.34 0.31 1.99e-7 RR interval (heart rate); CESC cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.85 -11.41 -0.57 8.26e-25 Multiple sclerosis; CESC cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg05340658 chr4:99064831 C4orf37 0.83 13.01 0.62 3e-30 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg11764359 chr7:65958608 NA 0.78 11.31 0.57 1.86e-24 Aortic root size; CESC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg19163074 chr7:65112434 INTS4L2 0.43 5.44 0.32 1.24e-7 Aortic root size; CESC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.1e-18 Prudent dietary pattern; CESC trans rs61931739 0.500 rs11053248 chr12:34518011 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.63 0.55 3.31e-22 Morning vs. evening chronotype; CESC cis rs11711311 0.824 rs35341324 chr3:113351719 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.61 7.74 0.43 2.07e-13 IgG glycosylation; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg06745955 chr17:27038470 PROCA1 0.45 6.04 0.35 5.14e-9 Breast cancer;Type 2 diabetes; CESC cis rs2625529 0.617 rs7175373 chr15:72203517 G/T cg16672083 chr15:72433130 SENP8 0.42 6.47 0.37 4.69e-10 Red blood cell count; CESC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg26343298 chr8:95960752 TP53INP1 0.37 5.94 0.34 8.73e-9 Type 2 diabetes; CESC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg00129232 chr17:37814104 STARD3 0.54 7.08 0.4 1.33e-11 Glomerular filtration rate (creatinine); CESC cis rs9486719 1.000 rs12190507 chr6:96898265 T/G cg18709589 chr6:96969512 KIAA0776 -0.54 -5.87 -0.34 1.3e-8 Migraine;Coronary artery disease; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg11319265 chr21:37258822 NA 0.4 6.28 0.36 1.38e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7512552 0.839 rs1097070 chr1:150332955 A/T cg15654264 chr1:150340011 RPRD2 0.39 5.24 0.31 3.25e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs10504073 0.647 rs4873317 chr8:50021111 C/T cg00325661 chr8:49890786 NA 0.57 8.6 0.47 7.15e-16 Blood metabolite ratios; CESC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg22920501 chr2:26401640 FAM59B -0.67 -8.09 -0.44 2.22e-14 Gut microbiome composition (summer); CESC cis rs3617 0.625 rs2336558 chr3:52886240 C/T cg07507251 chr3:52567010 NT5DC2 -0.32 -5.49 -0.32 9.52e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs10493773 0.609 rs2389972 chr1:86190666 A/G cg17807903 chr1:86174739 ZNHIT6 -0.41 -6.1 -0.35 3.74e-9 Urate levels in overweight individuals; CESC cis rs12142240 0.698 rs72677589 chr1:46817770 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC cis rs8017423 0.608 rs12588149 chr14:90822676 G/A cg14092571 chr14:90743983 NA 0.44 6.77 0.38 8.12e-11 Mortality in heart failure; CESC cis rs4909189 0.957 rs71547529 chr7:158135469 G/T cg06219351 chr7:158114137 PTPRN2 -0.61 -8.04 -0.44 3.09e-14 Response to amphetamines; CESC cis rs902774 0.554 rs4503623 chr12:53353759 T/C cg16329197 chr12:53359506 NA -0.55 -7.85 -0.43 1e-13 Prostate cancer; CESC cis rs79387448 0.745 rs78136548 chr2:103103740 T/G cg09003973 chr2:102972529 NA 0.85 6.24 0.36 1.68e-9 Gut microbiota (bacterial taxa); CESC cis rs2243480 0.615 rs34363376 chr7:65939536 T/C cg18252515 chr7:66147081 NA -1.39 -13.86 -0.65 3.27e-33 Diabetic kidney disease; CESC trans rs4295623 0.553 rs34962960 chr8:11594597 G/A cg15556689 chr8:8085844 FLJ10661 -0.54 -6.2 -0.36 2.14e-9 Morning vs. evening chronotype; CESC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg03188948 chr7:1209495 NA 0.74 7.92 0.44 6.39e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs561341 1.000 rs550923 chr17:30327013 G/C cg12193833 chr17:30244370 NA -0.72 -6.68 -0.38 1.42e-10 Hip circumference adjusted for BMI; CESC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg05564831 chr3:52568323 NT5DC2 -0.41 -6.18 -0.35 2.41e-9 Bipolar disorder; CESC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 9.59 0.51 6.99e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg15605315 chr1:45957053 TESK2 0.49 6.43 0.37 5.98e-10 High light scatter reticulocyte count; CESC cis rs10791323 0.593 rs2282604 chr11:133714672 A/G cg06766960 chr11:133703094 NA -0.36 -5.3 -0.31 2.4e-7 Childhood ear infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23233234 chr2:70528859 FAM136A 0.63 7.19 0.4 6.59e-12 Gut microbiome composition (summer); CESC cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 6.1e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs2274273 0.870 rs8018110 chr14:55641714 C/T cg04306507 chr14:55594613 LGALS3 0.3 5.97 0.34 7.68e-9 Protein biomarker; CESC cis rs7267979 0.932 rs4280527 chr20:25544014 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.74 13.18 0.63 7.58e-31 Liver enzyme levels (alkaline phosphatase); CESC trans rs60843830 1.000 rs6709534 chr2:217334 G/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 7.91 0.44 6.93e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg26035463 chr12:117627651 FBXO21 -0.47 -6.05 -0.35 5.02e-9 Height; CESC cis rs4604732 0.578 rs79203328 chr1:247626581 C/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9658691 0.607 rs9658750 chr10:90766596 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.6 -5.24 -0.31 3.33e-7 Mosquito bite size; CESC cis rs11098499 0.954 rs6857105 chr4:120222298 C/G cg09307838 chr4:120376055 NA 0.89 12.42 0.61 3.14e-28 Corneal astigmatism; CESC cis rs4268898 0.529 rs4426488 chr2:24372815 A/G cg20701182 chr2:24300061 SF3B14 -0.38 -5.28 -0.31 2.72e-7 Asthma; CESC cis rs1475911 0.708 rs8129075 chr21:43523430 G/T cg14562523 chr21:43528734 C21orf128;UMODL1 -0.48 -7.49 -0.42 1.03e-12 IgG glycosylation; CESC cis rs854765 0.583 rs4925123 chr17:17784374 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.46 -0.37 5.05e-10 Total body bone mineral density; CESC cis rs523522 0.962 rs4767912 chr12:120981202 A/G cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs561341 0.882 rs16967101 chr17:30377162 A/G cg19193384 chr17:30244184 NA -0.51 -5.24 -0.31 3.3e-7 Hip circumference adjusted for BMI; CESC cis rs7208859 0.573 rs73267865 chr17:29064204 C/G cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12971120 1.000 rs3829640 chr18:72174980 A/G cg25817165 chr18:72167213 CNDP2 -0.64 -8.22 -0.45 9.01e-15 Refractive error; CESC cis rs644799 1.000 rs488246 chr11:95560473 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.57e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.06 -0.35 4.65e-9 Parkinson's disease; CESC cis rs1348850 0.574 rs10195917 chr2:178443121 C/T cg23306229 chr2:178417860 TTC30B 0.59 6.19 0.36 2.27e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6964587 0.967 rs6980247 chr7:91594228 T/A cg17063962 chr7:91808500 NA 0.56 7.68 0.43 3.04e-13 Breast cancer; CESC cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2239547 0.522 rs6768844 chr3:53004620 A/G cg11645453 chr3:52864694 ITIH4 -0.32 -5.37 -0.31 1.7e-7 Schizophrenia; CESC cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg04455712 chr21:45112962 RRP1B 0.39 5.75 0.33 2.46e-8 Mean corpuscular volume; CESC trans rs55872338 0.588 rs79671379 chr10:44536443 A/G cg04664161 chr19:1876758 NA 0.63 6.13 0.35 3.16e-9 Facial morphology (factor 20); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17055371 chr11:3078785 CARS 0.6 7.09 0.4 1.21e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11725182 chr1:5968678 NPHP4 -0.71 -7.75 -0.43 2.02e-13 Gut microbiome composition (summer); CESC cis rs7937682 0.889 rs2850247 chr11:111637202 C/A cg09085632 chr11:111637200 PPP2R1B 1.15 19.47 0.77 5.1e-53 Primary sclerosing cholangitis; CESC cis rs2066819 1.000 rs59295315 chr12:56708576 G/A cg26804944 chr12:56660921 COQ10A -0.85 -5.14 -0.3 5.39e-7 Psoriasis vulgaris; CESC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.84 0.34 1.49e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2404618 0.534 rs2214861 chr8:1490604 A/G cg13402656 chr8:1511478 DLGAP2 -0.62 -9.69 -0.51 3.3e-19 Lung cancer; CESC cis rs9910055 0.502 rs1684662 chr17:42180822 T/A cg13607699 chr17:42295918 UBTF -0.44 -5.52 -0.32 8.02e-8 Total body bone mineral density; CESC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg18758796 chr5:131593413 PDLIM4 0.38 5.15 0.3 5.13e-7 Breast cancer; CESC cis rs72627123 0.531 rs3742806 chr14:74532523 A/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.36 0.31 1.81e-7 Morning vs. evening chronotype; CESC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg13628971 chr7:2884303 GNA12 0.65 8.5 0.46 1.43e-15 Height; CESC cis rs989128 0.600 rs9913677 chr17:48628581 T/A cg24438145 chr17:48624694 SPATA20 0.44 5.25 0.31 3.14e-7 Type 2 diabetes; CESC cis rs17376456 0.825 rs10054790 chr5:93272520 A/G cg21475434 chr5:93447410 FAM172A 0.81 6.49 0.37 4.2e-10 Diabetic retinopathy; CESC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg11890956 chr21:40555474 PSMG1 1.19 23.83 0.83 7.74e-68 Cognitive function; CESC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg06108461 chr20:60628389 TAF4 -0.89 -13.47 -0.64 7.2e-32 Body mass index; CESC cis rs4906332 1.000 rs11625172 chr14:103944912 G/A cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.49e-10 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21119375 chr2:44393385 NA -0.66 -7.28 -0.41 3.92e-12 Gut microbiome composition (summer); CESC trans rs72681920 0.881 rs12512110 chr4:100195815 A/C cg22948791 chr15:71404101 CT62 0.56 6.2 0.36 2.13e-9 Alcohol dependence; CESC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg10053473 chr17:62856997 LRRC37A3 -0.72 -7.9 -0.44 7.4e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12497850 0.865 rs7649458 chr3:48920127 C/T cg03060546 chr3:49711283 APEH 0.42 5.28 0.31 2.7e-7 Parkinson's disease; CESC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg06221963 chr1:154839813 KCNN3 -0.66 -11.11 -0.56 8.55e-24 Prostate cancer; CESC cis rs703842 1.000 rs10877013 chr12:58165085 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.71 9.23 0.49 8.87e-18 Multiple sclerosis; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg25798026 chr22:32149910 DEPDC5 -0.41 -6.18 -0.35 2.42e-9 Breast cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24780086 chr5:14713043 ANKH -0.44 -6.15 -0.35 2.78e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs757110 0.803 rs7928810 chr11:17372443 G/T cg15432903 chr11:17409602 KCNJ11 0.57 8.11 0.45 1.88e-14 Type 2 diabetes; CESC cis rs748404 0.516 rs523156 chr15:43811843 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -7.0 -0.39 2.13e-11 Lung cancer; CESC trans rs7618501 1.000 rs35261599 chr3:49773236 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -8.48 -0.46 1.65e-15 Intelligence (multi-trait analysis); CESC cis rs1506636 0.886 rs4731112 chr7:123269118 C/G cg03229431 chr7:123269106 ASB15 -0.51 -6.93 -0.39 3.2e-11 Plateletcrit;Platelet count; CESC cis rs9486719 1.000 rs12213426 chr6:96896035 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.21e-15 Migraine;Coronary artery disease; CESC cis rs6963495 0.818 rs73190166 chr7:105159955 G/A cg19920283 chr7:105172520 RINT1 0.68 6.34 0.36 9.71e-10 Bipolar disorder (body mass index interaction); CESC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg22535103 chr8:58192502 C8orf71 -0.77 -8.76 -0.47 2.37e-16 Developmental language disorder (linguistic errors); CESC cis rs7917772 0.582 rs10786689 chr10:104356359 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.63 0.33 4.48e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg12564285 chr5:131593104 PDLIM4 0.38 5.8 0.34 1.92e-8 Acylcarnitine levels; CESC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg04063615 chr12:132293388 NA -0.4 -5.23 -0.31 3.51e-7 Migraine; CESC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg18350739 chr11:68623251 NA -0.43 -6.73 -0.38 1.05e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg22029157 chr1:209979665 IRF6 0.69 10.11 0.53 1.57e-20 Cleft lip with or without cleft palate; CESC cis rs854765 0.547 rs7212167 chr17:17913504 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.17 0.4 7.52e-12 Total body bone mineral density; CESC cis rs7618501 0.699 rs1317154 chr3:49910084 T/C cg24308560 chr3:49941425 MST1R -0.67 -9.89 -0.52 7.66e-20 Intelligence (multi-trait analysis); CESC cis rs2070677 0.935 rs11812637 chr10:135413418 A/G cg20169779 chr10:135381914 SYCE1 -0.75 -9.88 -0.52 8.57e-20 Gout; CESC cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg04455712 chr21:45112962 RRP1B 0.53 8.19 0.45 1.09e-14 Mean corpuscular volume; CESC cis rs2573652 1.000 rs2573625 chr15:100513158 A/G cg00587665 chr15:100533223 ADAMTS17 0.33 5.11 0.3 6.14e-7 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26571942 chr2:30455099 LBH -0.47 -6.0 -0.35 6.4e-9 Ulcerative colitis; CESC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg10691866 chr7:65817282 TPST1 -0.35 -5.71 -0.33 3.1e-8 Aortic root size; CESC cis rs2243480 1.000 rs10247526 chr7:65780696 T/G cg18252515 chr7:66147081 NA 1.42 14.53 0.67 1.39e-35 Diabetic kidney disease; CESC cis rs3820068 0.603 rs7529759 chr1:15977877 A/G cg17385448 chr1:15911702 AGMAT 0.43 7.04 0.4 1.66e-11 Systolic blood pressure; CESC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.35 0.31 1.89e-7 Menopause (age at onset); CESC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg15664640 chr17:80829946 TBCD -0.65 -9.29 -0.5 5.91e-18 Breast cancer; CESC cis rs910316 0.935 rs175448 chr14:75591071 G/A cg08847533 chr14:75593920 NEK9 -0.98 -18.75 -0.76 1.61e-50 Height; CESC cis rs4722166 0.630 rs12700391 chr7:22777327 C/A cg26061582 chr7:22766209 IL6 0.51 5.55 0.32 6.82e-8 Lung cancer; CESC cis rs9888739 1.000 rs36001237 chr16:31318257 A/T cg15817542 chr16:31343056 ITGAM -0.41 -5.05 -0.3 8.33e-7 Systemic lupus erythematosus; CESC cis rs11792861 0.564 rs3816237 chr9:111718348 T/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.63 9.71 0.51 2.87e-19 Menarche (age at onset); CESC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg21782813 chr7:2030301 MAD1L1 0.5 7.17 0.4 7.6e-12 Bipolar disorder and schizophrenia; CESC cis rs208515 0.525 rs12204452 chr6:66680325 C/T cg07460842 chr6:66804631 NA 0.86 10.87 0.56 5.19e-23 Exhaled nitric oxide levels; CESC cis rs56046484 0.913 rs17611290 chr15:85574419 A/G cg08123816 chr15:85640762 PDE8A -0.49 -6.25 -0.36 1.63e-9 Testicular germ cell tumor; CESC cis rs7131987 0.903 rs918873 chr12:29390501 G/T cg09582351 chr12:29534625 ERGIC2 -0.34 -5.34 -0.31 1.97e-7 QT interval; CESC trans rs9354308 0.899 rs2802058 chr6:66550787 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.62 6.89 0.39 4.03e-11 Metabolite levels; CESC cis rs7684253 0.565 rs7680140 chr4:57823457 A/G cg21154227 chr4:57904332 IGFBP7 0.37 5.33 0.31 2.13e-7 Migraine; CESC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg16680214 chr1:154839983 KCNN3 0.51 8.03 0.44 3.1e-14 Prostate cancer; CESC cis rs6493487 0.512 rs58661036 chr15:51201780 A/C cg02338191 chr15:51200825 AP4E1 0.6 5.58 0.32 5.79e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7208859 0.524 rs77498725 chr17:29063986 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4555082 0.830 rs2816648 chr14:105708289 C/T cg13114125 chr14:105738426 BRF1 -0.87 -10.52 -0.54 7.51e-22 Mean platelet volume;Platelet distribution width; CESC cis rs2836633 0.929 rs11701577 chr21:40028906 C/T cg12884169 chr21:40033163 ERG 0.38 5.97 0.34 7.52e-9 Coronary artery disease; CESC cis rs7274811 0.681 rs186026 chr20:31951993 G/T cg21523528 chr20:32077966 CBFA2T2 -0.44 -5.31 -0.31 2.29e-7 Height; CESC cis rs826838 0.967 rs1719853 chr12:39128515 A/G cg26384229 chr12:38710491 ALG10B -0.66 -10.31 -0.54 3.42e-21 Heart rate; CESC trans rs1545843 0.593 rs11116362 chr12:84796506 T/C cg03015433 chr16:56623111 MT3 -0.34 -6.15 -0.35 2.82e-9 Major depressive disorder; CESC cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg19077165 chr18:44547161 KATNAL2 -0.6 -9.11 -0.49 2.13e-17 Personality dimensions; CESC cis rs947211 1.000 rs823144 chr1:205744546 C/A cg26354017 chr1:205819088 PM20D1 0.4 5.13 0.3 5.48e-7 Parkinson's disease; CESC cis rs57506017 0.540 rs1435527 chr7:12262571 C/T cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.51e-7 Neuroticism; CESC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg26314531 chr2:26401878 FAM59B -0.59 -6.67 -0.38 1.5e-10 Gut microbiome composition (summer); CESC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.38 -6.14 -0.35 2.97e-9 Cystic fibrosis severity; CESC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg03452623 chr4:187889614 NA -0.94 -19.24 -0.76 3.13e-52 Lobe attachment (rater-scored or self-reported); CESC cis rs4323050 0.510 rs4254715 chr4:144914293 T/G cg25736465 chr4:144833511 NA 0.43 6.44 0.37 5.61e-10 High light scatter reticulocyte percentage of red cells; CESC cis rs2120019 1.000 rs1867146 chr15:75354971 C/G cg09165964 chr15:75287851 SCAMP5 -0.73 -8.47 -0.46 1.7e-15 Blood trace element (Zn levels); CESC cis rs5758511 0.680 rs1107553 chr22:42667473 A/G cg00645731 chr22:42541494 CYP2D7P1 0.56 8.49 0.46 1.46e-15 Birth weight; CESC cis rs11792861 0.505 rs12377869 chr9:111907803 C/A cg13535736 chr9:111863775 C9orf5 -0.41 -5.8 -0.34 1.92e-8 Menarche (age at onset); CESC cis rs76878669 0.561 rs7110944 chr11:66118217 C/T cg18002602 chr11:66138449 SLC29A2 -0.42 -6.96 -0.39 2.67e-11 Educational attainment (years of education); CESC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg03060546 chr3:49711283 APEH 0.5 6.84 0.39 5.55e-11 Menarche (age at onset); CESC cis rs763121 0.853 rs138716 chr22:39146527 C/T cg14440974 chr22:39074834 NA -0.38 -5.13 -0.3 5.6e-7 Menopause (age at onset); CESC trans rs9354308 0.899 rs2814153 chr6:66557611 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.63 6.99 0.39 2.27e-11 Metabolite levels; CESC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg15445000 chr17:37608096 MED1 -0.41 -6.81 -0.39 6.37e-11 Glomerular filtration rate (creatinine); CESC cis rs2228479 0.850 rs12600051 chr16:89992072 G/T cg04013166 chr16:89971882 TCF25 0.79 6.58 0.37 2.57e-10 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03625676 chr5:156887393 NIPAL4 0.44 6.08 0.35 4.06e-9 Gut microbiome composition (summer); CESC cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg10556349 chr10:835070 NA 0.51 5.47 0.32 1.04e-7 Eosinophil percentage of granulocytes; CESC cis rs6665290 0.669 rs6426558 chr1:227175367 G/T cg10327440 chr1:227177885 CDC42BPA -1.14 -23.96 -0.83 2.82e-68 Myeloid white cell count; CESC cis rs317689 0.690 rs7969559 chr12:69655167 A/G cg14784868 chr12:69753453 YEATS4 0.51 5.78 0.33 2.12e-8 Response to diuretic therapy; CESC cis rs55986470 0.817 rs72993054 chr2:239404244 C/T cg18131467 chr2:239335373 ASB1 -0.7 -5.75 -0.33 2.42e-8 Chronotype; CESC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg04553112 chr3:125709451 NA -0.55 -5.82 -0.34 1.71e-8 Blood pressure (smoking interaction); CESC cis rs4862750 0.872 rs7664463 chr4:187876686 A/C cg03452623 chr4:187889614 NA -0.89 -16.49 -0.71 1.6e-42 Lobe attachment (rater-scored or self-reported); CESC cis rs7301826 0.571 rs4759788 chr12:131296314 T/C cg11011512 chr12:131303247 STX2 0.46 5.57 0.32 6.21e-8 Plasma plasminogen activator levels; CESC cis rs2243480 1.000 rs1638734 chr7:66097539 A/C cg08632164 chr7:65971372 NA -0.49 -5.15 -0.3 5.03e-7 Diabetic kidney disease; CESC trans rs61931739 0.500 rs11053211 chr12:34464334 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.49 0.42 1.02e-12 Morning vs. evening chronotype; CESC cis rs6987853 0.933 rs2923401 chr8:42442208 T/C cg09913449 chr8:42400586 C8orf40 0.4 6.27 0.36 1.46e-9 Mean corpuscular hemoglobin concentration; CESC cis rs10191773 0.589 rs72831634 chr2:112946796 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.71 -6.9 -0.39 3.9e-11 Yeast infection; CESC cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.67 8.05 0.44 2.87e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs6982240 0.514 rs10481391 chr8:142277149 A/G cg00131261 chr8:142287264 NA -0.54 -7.53 -0.42 8e-13 Tonsillectomy; CESC cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg05340658 chr4:99064831 C4orf37 0.73 10.38 0.54 2.13e-21 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg07507251 chr3:52567010 NT5DC2 0.4 7.1 0.4 1.15e-11 Bipolar disorder; CESC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.64 0.38 1.74e-10 Bipolar disorder; CESC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg12667521 chr19:29218732 NA 0.48 6.4 0.37 6.97e-10 Methadone dose in opioid dependence; CESC cis rs858239 0.601 rs11984129 chr7:23152677 A/G cg23682824 chr7:23144976 KLHL7 0.54 7.36 0.41 2.31e-12 Cerebrospinal fluid biomarker levels; CESC cis rs14403 1.000 rs14403 chr1:243663893 A/G cg21452805 chr1:244014465 NA -0.52 -5.93 -0.34 9.54e-9 Schizophrenia; CESC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg11301795 chr4:187892539 NA -0.75 -11.49 -0.58 4.49e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs3747547 0.642 rs11792197 chr9:38086999 C/T cg13774184 chr9:37916125 SHB -0.62 -5.3 -0.31 2.38e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg01988459 chr11:68622903 NA -0.42 -5.79 -0.34 1.99e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01399255 chr7:100271274 GNB2 0.64 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC trans rs17181170 0.574 rs34610470 chr3:87208044 G/A ch.2.199792288R chr2:200084043 NA -0.46 -6.1 -0.35 3.78e-9 Prostate cancer; CESC cis rs6568686 0.553 rs9372301 chr6:111903329 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.52 -5.17 -0.3 4.65e-7 Depressive and manic episodes in bipolar disorder;Depressive episodes in bipolar disorder; CESC cis rs7927771 0.542 rs7108479 chr11:47781460 G/T cg20307385 chr11:47447363 PSMC3 0.61 8.59 0.47 7.41e-16 Subjective well-being; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17816495 chr19:19030203 DDX49;COPE -0.52 -7.18 -0.4 7.25e-12 Fibrinogen levels; CESC cis rs17376456 0.825 rs17372057 chr5:93071916 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.34 0.31 2e-7 Diabetic retinopathy; CESC cis rs7100689 0.646 rs2050824 chr10:82123563 G/A cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs17854409 0.764 rs16983293 chr20:61479056 A/G cg05147244 chr20:61493195 TCFL5 0.99 5.52 0.32 8.1e-8 Obesity-related traits; CESC cis rs56046484 0.871 rs7177110 chr15:85671755 A/G cg08123816 chr15:85640762 PDE8A -0.44 -5.57 -0.32 6.33e-8 Testicular germ cell tumor; CESC cis rs9287719 0.639 rs2357650 chr2:10696877 C/T cg00105475 chr2:10696890 NA 0.44 6.56 0.37 2.88e-10 Prostate cancer; CESC cis rs1801251 0.963 rs66549961 chr2:233602293 A/G cg08000102 chr2:233561755 GIGYF2 0.66 9.34 0.5 4.2e-18 Coronary artery disease; CESC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg20243544 chr17:37824526 PNMT 0.44 5.38 0.31 1.61e-7 Glomerular filtration rate (creatinine); CESC trans rs853679 0.882 rs9461432 chr6:28086883 T/C cg06606381 chr12:133084897 FBRSL1 -0.65 -6.43 -0.37 5.96e-10 Depression; CESC cis rs2439831 0.681 rs540388 chr15:43606494 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.87 12.92 0.62 5.83e-30 Lung cancer in ever smokers; CESC cis rs36051895 0.626 rs12349785 chr9:5076613 G/C cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.59e-9 Pediatric autoimmune diseases; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16031872 chr3:142297641 ATR 0.58 6.18 0.35 2.37e-9 Gut microbiome composition (summer); CESC cis rs7917772 0.503 rs11191342 chr10:104344450 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.33 -0.36 1.07e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg21770322 chr7:97807741 LMTK2 -0.57 -8.59 -0.47 7.75e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs2777491 0.915 rs8036498 chr15:41603276 A/G cg20272979 chr15:41787780 ITPKA 0.36 5.19 0.3 4.25e-7 Ulcerative colitis; CESC cis rs75477785 0.590 rs7528642 chr1:209916598 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.76 5.09 0.3 6.66e-7 Cleft lip with or without cleft palate; CESC cis rs11203032 0.831 rs11203018 chr10:90948783 T/C cg16672925 chr10:90967113 CH25H 0.72 7.16 0.4 7.78e-12 Heart failure; CESC cis rs2625529 0.652 rs8027164 chr15:72407733 A/T cg16672083 chr15:72433130 SENP8 0.45 7.06 0.4 1.49e-11 Red blood cell count; CESC cis rs2898681 0.521 rs115874483 chr4:53728272 G/A cg00791764 chr4:53727839 RASL11B 0.44 5.26 0.31 3.03e-7 Optic nerve measurement (cup area); CESC cis rs9457247 1.000 rs406095 chr6:167409087 C/T cg23791538 chr6:167370224 RNASET2 -0.61 -8.81 -0.48 1.71e-16 Crohn's disease; CESC trans rs10463316 0.894 rs6579866 chr5:150762524 A/G cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs60154123 0.554 rs1338290 chr1:210465467 G/A cg21951975 chr1:209979733 IRF6 0.46 5.99 0.35 6.98e-9 Coronary artery disease; CESC cis rs2952156 0.959 rs2517956 chr17:37843859 G/A cg07936489 chr17:37558343 FBXL20 -0.52 -6.17 -0.35 2.49e-9 Asthma; CESC cis rs3796619 0.503 rs1466216 chr4:1071907 C/T cg27284194 chr4:1044797 NA -0.56 -9.01 -0.48 4.1e-17 Recombination rate (males); CESC cis rs9818941 0.824 rs2686541 chr3:157788184 G/C cg08654915 chr3:157813417 NA -0.43 -7.1 -0.4 1.13e-11 Height; CESC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.72 0.43 2.43e-13 Prudent dietary pattern; CESC trans rs877282 0.853 rs10904544 chr10:756966 A/G cg22713356 chr15:30763199 NA 0.95 8.36 0.46 3.67e-15 Uric acid levels; CESC cis rs911555 0.755 rs11627446 chr14:103946450 G/C cg09975044 chr14:104007538 NA 0.43 5.31 0.31 2.33e-7 Intelligence (multi-trait analysis); CESC cis rs1048238 0.506 rs7547314 chr1:16186722 G/A cg21385522 chr1:16154831 NA 0.45 5.82 0.34 1.7e-8 Systolic blood pressure; CESC cis rs459571 0.959 rs2073818 chr9:136918662 C/A cg13789015 chr9:136890014 NCRNA00094 0.57 8.07 0.44 2.49e-14 Platelet distribution width; CESC cis rs17376456 0.542 rs10476588 chr5:93208330 C/T cg25358565 chr5:93447407 FAM172A -0.71 -7.46 -0.42 1.23e-12 Diabetic retinopathy; CESC cis rs16857609 0.564 rs3732009 chr2:218291393 G/A cg15335768 chr2:218268053 DIRC3 -0.37 -5.19 -0.3 4.18e-7 Breast cancer;Breast cancer (estrogen-receptor negative); CESC cis rs7621025 0.617 rs12637102 chr3:136211960 A/G cg15507776 chr3:136538369 TMEM22 0.44 5.11 0.3 6.3e-7 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC trans rs7839040 0.698 rs12549223 chr8:82932601 A/G cg14472086 chr9:107730925 NA -0.46 -6.24 -0.36 1.69e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg26314531 chr2:26401878 FAM59B 0.85 9.23 0.49 8.65e-18 Gut microbiome composition (summer); CESC cis rs11191270 0.554 rs11191253 chr10:104066507 A/T cg15320455 chr10:103880129 LDB1 0.61 5.68 0.33 3.54e-8 Intelligence (multi-trait analysis); CESC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg01017244 chr2:74357527 NA 0.8 10.39 0.54 1.99e-21 Gestational age at birth (maternal effect); CESC cis rs6546550 0.803 rs10165883 chr2:70117015 C/T cg02498382 chr2:70120550 SNRNP27 -0.41 -7.02 -0.4 1.87e-11 Prevalent atrial fibrillation; CESC cis rs7937682 0.883 rs568506 chr11:111466429 C/T cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC cis rs2404602 0.647 rs12910820 chr15:77022825 T/C cg23625390 chr15:77176239 SCAPER -0.46 -6.38 -0.36 8.06e-10 Blood metabolite levels; CESC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg21984481 chr17:79567631 NPLOC4 -0.34 -5.2 -0.3 4.08e-7 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26465743 chr13:77901232 MYCBP2 -0.61 -7.11 -0.4 1.05e-11 Gut microbiome composition (summer); CESC cis rs9611565 0.559 rs7290990 chr22:41964357 C/A cg17376030 chr22:41985996 PMM1 0.53 5.88 0.34 1.25e-8 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07391756 chr12:132568647 EP400NL 0.65 7.36 0.41 2.28e-12 Gut microbiome composition (summer); CESC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 10.86 0.55 5.83e-23 Platelet count; CESC cis rs4849845 0.637 rs62168279 chr2:121026771 T/C cg24070213 chr2:121070622 NA 0.45 6.51 0.37 3.82e-10 Mean platelet volume; CESC cis rs752010 0.841 rs7519983 chr1:42083369 C/T cg06885757 chr1:42089581 HIVEP3 0.47 7.71 0.43 2.5e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs3785574 0.962 rs114027117 chr17:61939935 T/A cg01411255 chr17:61851458 DDX42;CCDC47 1.08 19.81 0.77 3.37e-54 Height; CESC cis rs478304 0.934 rs610037 chr11:65546857 A/C cg08755490 chr11:65554678 OVOL1 0.52 6.85 0.39 5.28e-11 Acne (severe); CESC cis rs916888 0.773 rs199534 chr17:44824213 T/G cg15921436 chr17:44337874 NA 0.72 7.62 0.42 4.52e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg06481639 chr22:41940642 POLR3H -0.54 -5.6 -0.33 5.29e-8 Vitiligo; CESC cis rs6987853 0.623 rs10109400 chr8:42455353 T/C cg09913449 chr8:42400586 C8orf40 0.42 7.02 0.4 1.88e-11 Mean corpuscular hemoglobin concentration; CESC cis rs796364 0.951 rs1105964 chr2:201000776 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -6.23 -0.36 1.87e-9 Schizophrenia; CESC cis rs7845219 0.544 rs4570121 chr8:95917088 C/T cg13393036 chr8:95962371 TP53INP1 -0.43 -8.01 -0.44 3.67e-14 Type 2 diabetes; CESC cis rs763121 0.853 rs926299 chr22:39095698 C/G cg06022373 chr22:39101656 GTPBP1 0.94 17.4 0.73 9.39e-46 Menopause (age at onset); CESC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -11.01 -0.56 1.81e-23 Alzheimer's disease; CESC cis rs941873 0.835 rs4246944 chr10:81105684 C/T cg08514558 chr10:81106712 PPIF 0.33 5.66 0.33 4.01e-8 Height; CESC trans rs2727020 0.635 rs7124266 chr11:49280857 T/G cg15704280 chr7:45808275 SEPT13 0.81 10.93 0.56 3.32e-23 Coronary artery disease; CESC cis rs75804782 0.521 rs72993074 chr2:239413582 T/G cg18131467 chr2:239335373 ASB1 -0.73 -5.44 -0.32 1.19e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs17655565 0.581 rs2298794 chr12:52760732 G/A cg00777198 chr12:52828273 KRT75 0.37 5.09 0.3 6.7e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg18765753 chr7:1198926 ZFAND2A -0.4 -5.87 -0.34 1.31e-8 Longevity;Endometriosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14539990 chr9:140728301 EHMT1 0.47 6.54 0.37 3.13e-10 Fibrinogen levels; CESC trans rs853679 0.556 rs45509595 chr6:27840926 T/C cg21479132 chr6:26055353 NA 0.83 6.03 0.35 5.51e-9 Depression; CESC cis rs524023 0.914 rs7932437 chr11:64373504 T/C cg07220939 chr11:64358617 SLC22A12 -0.34 -5.18 -0.3 4.35e-7 Urate levels in obese individuals; CESC cis rs2243480 1.000 rs6959002 chr7:65650496 A/G cg12463550 chr7:65579703 CRCP -0.73 -5.66 -0.33 4.03e-8 Diabetic kidney disease; CESC cis rs7264396 0.836 rs6058276 chr20:34187728 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -7.07 -0.4 1.38e-11 Total cholesterol levels; CESC cis rs2197308 0.594 rs9705810 chr12:37895003 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.12 -0.4 1.01e-11 Morning vs. evening chronotype; CESC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.89 0.52 7.86e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8078723 0.630 rs60137005 chr17:38129996 A/T cg17467752 chr17:38218738 THRA 0.57 8.36 0.46 3.52e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs1864400 0.645 rs2249005 chr10:43627280 A/G cg07801480 chr10:43725741 RASGEF1A 0.43 5.44 0.32 1.2e-7 Hirschsprung disease; CESC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg00310523 chr12:86230176 RASSF9 -0.32 -5.03 -0.3 8.9e-7 Major depressive disorder; CESC cis rs963731 0.649 rs2924714 chr2:39333288 A/G cg04010122 chr2:39346883 SOS1 -0.76 -5.65 -0.33 4.05e-8 Corticobasal degeneration; CESC cis rs1707322 1.000 rs9793167 chr1:46446800 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3762318 0.951 rs12095536 chr1:67600142 T/C cg17031739 chr1:67600172 NA 0.5 5.29 0.31 2.57e-7 Leprosy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15806038 chr2:3601756 RNASEH1 0.42 6.71 0.38 1.16e-10 Gambling; CESC cis rs4727027 0.933 rs6464940 chr7:148826309 G/T cg23158103 chr7:148848205 ZNF398 -0.4 -6.34 -0.36 9.68e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs55883249 0.958 rs113937820 chr2:9746668 A/G cg23886495 chr2:9695866 ADAM17 0.66 5.87 0.34 1.29e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC trans rs61931739 0.500 rs7955933 chr12:34473608 A/G cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.67e-12 Morning vs. evening chronotype; CESC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg09365446 chr1:150670422 GOLPH3L 0.39 5.11 0.3 6.18e-7 Melanoma; CESC cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg21226059 chr5:178986404 RUFY1 0.45 6.32 0.36 1.09e-9 Lung cancer; CESC cis rs9303280 0.901 rs2952140 chr17:37928059 C/T cg20243544 chr17:37824526 PNMT -0.53 -7.32 -0.41 3.05e-12 Self-reported allergy; CESC cis rs7551222 0.749 rs6594018 chr1:204568152 A/G cg20240347 chr1:204465584 NA -0.26 -5.38 -0.31 1.65e-7 Schizophrenia; CESC cis rs1538970 0.851 rs2055145 chr1:45926495 C/G cg06784218 chr1:46089804 CCDC17 0.37 6.02 0.35 5.78e-9 Platelet count; CESC cis rs599083 0.530 rs667126 chr11:68177728 C/T cg01657329 chr11:68192670 LRP5 0.44 5.24 0.31 3.32e-7 Bone mineral density (spine); CESC cis rs1865721 1.000 rs72977888 chr18:73195250 C/T cg26385618 chr18:73139727 C18orf62 -0.51 -7.6 -0.42 5.1e-13 Intelligence; CESC trans rs1728785 0.892 rs4783562 chr16:68562963 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.62 7.2 0.4 6.15e-12 Ulcerative colitis; CESC cis rs7809950 0.678 rs2237665 chr7:106906998 T/C cg23024343 chr7:107201750 COG5 -0.54 -6.79 -0.38 7.55e-11 Coronary artery disease; CESC cis rs3806843 0.741 rs2563293 chr5:140110536 T/C cg26395211 chr5:140044315 WDR55 0.47 6.08 0.35 4.27e-9 Depressive symptoms (multi-trait analysis); CESC cis rs8133932 0.654 rs371587 chr21:47348512 G/A cg14185626 chr21:47401492 COL6A1 -0.48 -5.36 -0.31 1.78e-7 Schizophrenia; CESC cis rs10484885 0.793 rs9359862 chr6:90474508 A/G cg13799429 chr6:90582589 CASP8AP2 0.7 7.94 0.44 5.6e-14 QRS interval (sulfonylurea treatment interaction); CESC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg09365446 chr1:150670422 GOLPH3L 0.38 5.06 0.3 7.7300000000000005e-07 Melanoma; CESC cis rs933688 0.652 rs4916856 chr5:90596403 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.56 -7.12 -0.4 1e-11 Smoking behavior; CESC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.71e-40 Aortic root size; CESC cis rs12497850 1.000 rs4858798 chr3:48727112 C/T cg07636037 chr3:49044803 WDR6 0.91 16.19 0.71 1.89e-41 Parkinson's disease; CESC cis rs2635047 0.875 rs2635040 chr18:44640972 G/T cg19077165 chr18:44547161 KATNAL2 -0.54 -7.31 -0.41 3.11e-12 Educational attainment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26147668 chr7:130081239 TSGA14 -0.54 -6.37 -0.36 8.45e-10 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs28693609 chr4:17645233 C/T cg02297831 chr4:17616191 MED28 0.53 6.64 0.38 1.76e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs11711311 1.000 rs9828449 chr3:113518602 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.74 10.44 0.54 1.33e-21 IgG glycosylation; CESC cis rs9911578 0.967 rs8072712 chr17:57162464 A/T cg05425664 chr17:57184151 TRIM37 -0.53 -7.31 -0.41 3.23e-12 Intelligence (multi-trait analysis); CESC cis rs4642101 0.640 rs3901666 chr3:12824363 G/T cg05775895 chr3:12838266 CAND2 -0.36 -5.51 -0.32 8.64e-8 QRS complex (12-leadsum); CESC cis rs902774 0.597 rs7299694 chr12:53352572 A/C cg05393297 chr12:53359155 NA -0.6 -8.46 -0.46 1.88e-15 Prostate cancer; CESC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg10691866 chr7:65817282 TPST1 -0.36 -6.13 -0.35 3.09e-9 Aortic root size; CESC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg08859206 chr1:53392774 SCP2 0.63 9.32 0.5 4.63e-18 Monocyte count; CESC trans rs17716202 0.702 rs67311922 chr5:55892488 T/C cg14306956 chr9:37027384 PAX5 -0.55 -6.01 -0.35 6.15e-9 Psychosis in Alzheimer's disease; CESC cis rs754466 0.580 rs12357670 chr10:79558180 T/C cg17075019 chr10:79541650 NA -0.89 -14.04 -0.65 7.43e-34 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs889398 0.802 rs2937121 chr16:69870409 T/G cg09409435 chr16:70099608 PDXDC2 -0.42 -5.26 -0.31 2.92e-7 Body mass index; CESC cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg08564027 chr20:61660810 NA 0.9 15.36 0.69 1.69e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg03806693 chr22:41940476 POLR3H 1.13 15.27 0.68 3.52e-38 Vitiligo; CESC cis rs2014572 0.901 rs35658377 chr19:57755627 T/G cg12963866 chr19:57752005 ZNF805 -0.48 -6.47 -0.37 4.63e-10 Hyperactive-impulsive symptoms; CESC cis rs7584330 0.666 rs72620819 chr2:238354982 C/T cg14458575 chr2:238380390 NA 0.86 10.89 0.56 4.57e-23 Prostate cancer; CESC cis rs4664308 0.935 rs6731260 chr2:160977769 A/G cg03641300 chr2:160917029 PLA2R1 -0.66 -9.69 -0.51 3.34e-19 Idiopathic membranous nephropathy; CESC cis rs6032067 0.641 rs62206437 chr20:43759316 T/C cg10761708 chr20:43804764 PI3 0.48 5.18 0.3 4.44e-7 Blood protein levels; CESC cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg11266682 chr4:10021025 SLC2A9 -0.57 -10.49 -0.54 9.49e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1577917 0.771 rs4441928 chr6:86241894 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.52 7.33 0.41 2.86e-12 Response to antipsychotic treatment; CESC cis rs2228479 0.867 rs11642451 chr16:89958127 T/C cg06558623 chr16:89946397 TCF25 1.08 9.18 0.49 1.3e-17 Skin colour saturation; CESC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg09976981 chr22:43564007 TTLL12 0.47 7.0 0.4 2.09e-11 Response to TNF-alpha inhibitors in rheumatoid arthritis; CESC cis rs9623117 1.000 rs9611257 chr22:40455378 T/A cg05033341 chr22:40419857 FAM83F -0.43 -5.21 -0.3 3.8e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs4919044 0.740 rs73319304 chr10:94777045 A/G cg00487187 chr10:94451625 HHEX -0.45 -5.05 -0.3 8.21e-7 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07849438 chr12:19593035 AEBP2 -0.47 -6.58 -0.37 2.49e-10 Fibrinogen levels; CESC cis rs62005083 0.500 rs10135300 chr14:74574561 G/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.53 5.77 0.33 2.16e-8 Mean corpuscular volume; CESC trans rs11039798 0.841 rs11039783 chr11:48526828 G/C cg15704280 chr7:45808275 SEPT13 0.7 6.47 0.37 4.71e-10 Axial length; CESC cis rs7267979 0.934 rs2261115 chr20:25259807 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 16.87 0.72 7.12e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg25985355 chr7:65971099 NA 0.32 5.27 0.31 2.86e-7 Aortic root size; CESC cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg25019033 chr10:957182 NA -0.58 -6.28 -0.36 1.37e-9 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg18180107 chr4:99064573 C4orf37 -0.4 -5.2 -0.3 3.98e-7 Colonoscopy-negative controls vs population controls; CESC cis rs847577 0.569 rs2394817 chr7:97690438 C/T cg24562669 chr7:97807699 LMTK2 0.77 13.04 0.63 2.29e-30 Breast cancer; CESC cis rs7542091 0.666 rs7537070 chr1:210043565 A/G cg09509183 chr1:209979624 IRF6 0.4 5.78 0.33 2.12e-8 Monobrow; CESC cis rs929354 0.806 rs28446734 chr7:156996775 T/C cg05182265 chr7:156933206 UBE3C -0.5 -7.2 -0.4 6.35e-12 Body mass index; CESC cis rs12476592 0.602 rs2305157 chr2:63822785 T/C cg17519650 chr2:63277830 OTX1 -0.46 -5.14 -0.3 5.28e-7 Childhood ear infection; CESC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.78 9.65 0.51 4.6e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs9790314 0.967 rs6762645 chr3:160948349 T/G cg04691961 chr3:161091175 C3orf57 -0.4 -5.07 -0.3 7.61e-7 Morning vs. evening chronotype; CESC cis rs477692 0.699 rs471390 chr10:131382825 A/G cg24747557 chr10:131355152 MGMT 0.37 5.1 0.3 6.41e-7 Response to temozolomide; CESC cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.4 0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.42 -0.32 1.31e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs17253792 0.822 rs78820104 chr14:56068854 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs75477785 0.590 rs4844941 chr1:210220118 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.91 6.32 0.36 1.09e-9 Cleft lip with or without cleft palate; CESC cis rs9487051 0.676 rs6928622 chr6:109595112 C/T cg01475377 chr6:109611718 NA -0.44 -7.02 -0.4 1.84e-11 Reticulocyte fraction of red cells; CESC cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg02187348 chr16:89574699 SPG7 -0.54 -7.24 -0.41 4.82e-12 Multiple myeloma (IgH translocation); CESC trans rs7819412 0.775 rs2001329 chr8:10986859 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -6.13 -0.35 3.12e-9 Triglycerides; CESC cis rs2279817 1.000 rs2279816 chr1:18021867 T/C cg21791023 chr1:18019539 ARHGEF10L 0.57 8.09 0.45 2.1e-14 Neuroticism; CESC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg09658497 chr7:2847517 GNA12 -0.44 -6.25 -0.36 1.64e-9 Height; CESC cis rs6541297 1.000 rs4846836 chr1:230281316 G/A cg20703242 chr1:230279135 GALNT2 0.68 10.88 0.56 4.75e-23 Coronary artery disease; CESC cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg08847533 chr14:75593920 NEK9 0.92 16.29 0.71 8.22e-42 Height; CESC cis rs228769 0.543 rs170634 chr17:42175821 C/A cg19774624 chr17:42201019 HDAC5 0.62 8.74 0.47 2.71e-16 Bone mineral density (hip);Bone mineral density (spine); CESC cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg16339924 chr4:17578868 LAP3 0.83 10.53 0.54 6.69e-22 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs397969 0.573 rs203475 chr17:19850975 A/G cg12073167 chr17:19770448 ULK2 -0.45 -5.28 -0.31 2.72e-7 Platelet count; CESC cis rs8062405 0.755 rs4788074 chr16:28593597 A/G cg01378222 chr16:28622494 SULT1A1 -0.32 -5.53 -0.32 7.72e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg21679509 chr7:28219613 JAZF1 0.44 6.4 0.37 7.03e-10 Bronchopulmonary dysplasia; CESC cis rs9811920 0.732 rs793446 chr3:99578114 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -7.99 -0.44 4.14e-14 Axial length; CESC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg04369109 chr6:150039330 LATS1 -0.43 -6.0 -0.35 6.34e-9 Lung cancer; CESC cis rs1355223 0.506 rs12294339 chr11:34860199 C/T cg06937548 chr11:34938143 PDHX;APIP 0.42 5.06 0.3 7.87e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6547741 0.844 rs9941696 chr2:27920064 C/T cg27432699 chr2:27873401 GPN1 -0.61 -9.02 -0.48 3.99e-17 Oral cavity cancer; CESC trans rs35110281 0.720 rs162376 chr21:44926759 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.53 -7.09 -0.4 1.2e-11 Mean corpuscular volume; CESC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs2243480 0.901 rs35087093 chr7:65405208 C/T cg25894440 chr7:65020034 NA -0.59 -5.07 -0.3 7.57e-7 Diabetic kidney disease; CESC cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.23e-15 Colonoscopy-negative controls vs population controls; CESC cis rs4253772 0.591 rs6007748 chr22:46657798 A/G cg09491104 chr22:46646882 C22orf40 -0.6 -8.98 -0.48 5.18e-17 LDL cholesterol;Cholesterol, total; CESC cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg20476274 chr7:133979776 SLC35B4 0.68 9.92 0.52 6.24e-20 Mean platelet volume; CESC cis rs76793172 0.623 rs8107744 chr19:46300848 C/A cg12641515 chr19:46296257 DMWD 0.62 5.17 0.3 4.65e-7 Eosinophil counts; CESC trans rs57221529 0.766 rs56216231 chr5:581193 G/A cg25482853 chr8:67687455 SGK3 1.0 10.02 0.52 2.96e-20 Lung disease severity in cystic fibrosis; CESC cis rs12477438 0.520 rs7604557 chr2:99747829 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 16.02 0.7 7.14e-41 Chronic sinus infection; CESC cis rs9611565 0.649 rs738422 chr22:42123399 C/T cg06481639 chr22:41940642 POLR3H 0.48 5.56 0.32 6.63e-8 Vitiligo; CESC cis rs113835537 0.529 rs3741360 chr11:66300348 A/G cg22134325 chr11:66188745 NPAS4 0.39 5.84 0.34 1.51e-8 Airway imaging phenotypes; CESC cis rs5758659 0.519 rs133307 chr22:42396568 C/A cg15557168 chr22:42548783 NA -0.43 -6.34 -0.36 9.93e-10 Cognitive function; CESC cis rs6032067 0.777 rs34163611 chr20:43778990 T/C cg11264863 chr20:43835661 SEMG1 0.5 5.37 0.31 1.75e-7 Blood protein levels; CESC cis rs2997447 0.846 rs72886619 chr1:26452604 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.16 0.3 4.74e-7 QRS complex (12-leadsum); CESC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg10691866 chr7:65817282 TPST1 0.33 5.53 0.32 7.81e-8 Aortic root size; CESC cis rs2242116 0.761 rs6780601 chr3:46965856 A/G cg27129171 chr3:47204927 SETD2 0.53 6.76 0.38 8.94e-11 Birth weight; CESC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg03709012 chr19:19516395 GATAD2A -0.99 -15.52 -0.69 4.48e-39 Tonsillectomy; CESC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg06028808 chr11:68637592 NA 0.42 5.19 0.3 4.21e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17896229 chr20:5294595 PROKR2 0.39 6.16 0.35 2.65e-9 Fibrinogen levels; CESC cis rs4072980 0.524 rs28442147 chr1:38395410 T/A cg18451016 chr1:38461880 NA 0.42 6.03 0.35 5.45e-9 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15019617 chr10:91152447 IFIT1 0.47 6.01 0.35 5.96e-9 Gut microbiota (bacterial taxa); CESC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.73 0.47 2.92e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7927771 1.000 rs10838748 chr11:47716381 T/G cg20307385 chr11:47447363 PSMC3 -0.48 -5.87 -0.34 1.27e-8 Subjective well-being; CESC cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg24110177 chr3:50126178 RBM5 -0.53 -7.26 -0.41 4.23e-12 Intelligence (multi-trait analysis); CESC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg13206674 chr6:150067644 NUP43 0.46 6.59 0.38 2.43e-10 Lung cancer; CESC cis rs6500602 0.855 rs2304631 chr16:4475868 A/T cg08645402 chr16:4508243 NA 0.38 5.2 0.3 3.96e-7 Schizophrenia; CESC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg19163074 chr7:65112434 INTS4L2 0.46 5.57 0.32 6.37e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07237882 chr5:137090689 HNRNPA0 0.6 7.06 0.4 1.5e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.71 0.62 3.31e-29 Gut microbiome composition (summer); CESC cis rs1874326 0.545 rs4574789 chr7:138109427 C/A cg18008034 chr7:138118925 NA -0.41 -5.14 -0.3 5.34e-7 Quantitative traits; CESC trans rs62103177 0.564 rs7228971 chr18:77738025 C/T cg05926928 chr17:57297772 GDPD1 -0.7 -6.34 -0.36 9.91e-10 Opioid sensitivity; CESC cis rs2191566 0.691 rs55812285 chr19:44587930 T/C cg20607764 chr19:44506953 ZNF230 -0.4 -5.2 -0.3 4.04e-7 Acute lymphoblastic leukemia (childhood); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05614267 chr16:69373129 NIP7;COG8 -0.37 -6.02 -0.35 5.72e-9 Gambling; CESC cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg24920358 chr1:40204285 PPIE 0.43 6.4 0.37 7.07e-10 Blood protein levels; CESC cis rs870825 0.616 rs12502860 chr4:185636105 T/C cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs17826219 0.561 rs562840 chr17:28949390 G/T cg04154034 chr17:28927549 LRRC37B2 0.62 6.01 0.35 6e-9 Body mass index; CESC cis rs854765 0.583 rs8075965 chr17:17853180 A/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.14 0.4 8.73e-12 Total body bone mineral density; CESC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.64 0.38 1.82e-10 Bipolar disorder; CESC cis rs9911578 0.867 rs72628394 chr17:57121313 C/T cg05425664 chr17:57184151 TRIM37 0.51 7.07 0.4 1.34e-11 Intelligence (multi-trait analysis); CESC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg03806693 chr22:41940476 POLR3H 1.18 13.88 0.65 2.76e-33 Vitiligo; CESC cis rs2249625 0.545 rs60835713 chr6:72880349 T/C cg18830697 chr6:72922368 RIMS1 0.42 5.94 0.34 8.7e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs11031096 0.782 rs10767845 chr11:4156922 C/T cg18678763 chr11:4115507 RRM1 -0.46 -6.31 -0.36 1.19e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg02869306 chr7:64672164 INTS4L1 0.33 5.21 0.3 3.87e-7 Calcium levels; CESC trans rs11720469 0.967 rs7430936 chr3:166500933 G/A cg03163944 chr19:37663716 ZNF585A -0.41 -6.06 -0.35 4.65e-9 Fast beta electroencephalogram; CESC cis rs2279817 0.818 rs71644062 chr1:17980530 C/T cg21791023 chr1:18019539 ARHGEF10L -0.67 -7.92 -0.44 6.76e-14 Neuroticism; CESC cis rs854765 0.583 rs9635697 chr17:17870394 T/A cg16928487 chr17:17741425 SREBF1 -0.57 -9.55 -0.51 9.29e-19 Total body bone mineral density; CESC cis rs12325245 0.536 rs12931051 chr16:58626534 C/T cg02549819 chr16:58548995 SETD6 0.95 6.11 0.35 3.54e-9 Schizophrenia; CESC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg08470875 chr2:26401718 FAM59B 0.75 7.76 0.43 1.81e-13 Gut microbiome composition (summer); CESC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs763121 0.813 rs2179143 chr22:39037984 A/G cg21395723 chr22:39101663 GTPBP1 0.39 5.1 0.3 6.63e-7 Menopause (age at onset); CESC cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg19717773 chr7:2847554 GNA12 -0.49 -7.39 -0.41 1.94e-12 Height; CESC cis rs56873913 0.904 rs7251295 chr19:50096859 G/C cg09250473 chr19:50168907 IRF3;BCL2L12 0.46 5.04 0.3 8.57e-7 Schizophrenia; CESC cis rs9457247 1.000 rs404222 chr6:167402150 G/A cg25258033 chr6:167368657 RNASET2 0.38 5.84 0.34 1.54e-8 Crohn's disease; CESC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg12463550 chr7:65579703 CRCP -0.57 -7.38 -0.41 2.04e-12 Aortic root size; CESC cis rs9929218 0.817 rs3114404 chr16:68722096 C/T cg02972257 chr16:68554789 NA 0.6 6.53 0.37 3.34e-10 Colorectal cancer; CESC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg19774624 chr17:42201019 HDAC5 -0.64 -7.83 -0.43 1.19e-13 Total body bone mineral density; CESC cis rs27434 0.583 rs151909 chr5:96156888 T/C cg16492584 chr5:96139282 ERAP1 -0.36 -5.09 -0.3 6.81e-7 Ankylosing spondylitis; CESC cis rs10779751 1.000 rs1064261 chr1:11288758 C/T cg08854313 chr1:11322531 MTOR 0.77 10.66 0.55 2.65e-22 Body mass index; CESC cis rs7116495 0.609 rs11235444 chr11:71831859 G/A cg10381502 chr11:71823885 C11orf51 1.16 7.33 0.41 2.77e-12 Severe influenza A (H1N1) infection; CESC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg02187348 chr16:89574699 SPG7 0.61 8.51 0.46 1.3e-15 Multiple myeloma (IgH translocation); CESC cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg13298116 chr11:62369859 EML3;MTA2 0.62 9.13 0.49 1.81e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs116095464 0.558 rs55776650 chr5:273826 G/A cg22857025 chr5:266934 NA -1.3 -18.75 -0.76 1.71e-50 Breast cancer; CESC cis rs17401966 0.931 rs12131441 chr1:10428952 G/A cg15208524 chr1:10270712 KIF1B 0.4 5.14 0.3 5.37e-7 Hepatocellular carcinoma; CESC cis rs67460515 0.892 rs13073147 chr3:161045237 T/C cg03342759 chr3:160939853 NMD3 -0.54 -7.73 -0.43 2.27e-13 Parkinson's disease; CESC cis rs6499255 0.951 rs74026882 chr16:69635059 A/G cg15192750 chr16:69999425 NA 0.51 5.98 0.34 7.11e-9 IgE levels; CESC cis rs6456156 0.565 rs12529238 chr6:167465576 G/A cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.13e-10 Primary biliary cholangitis; CESC cis rs938554 0.571 rs12509955 chr4:10024303 C/T cg00071950 chr4:10020882 SLC2A9 -0.63 -7.83 -0.43 1.19e-13 Blood metabolite levels; CESC cis rs6500602 0.702 rs4786493 chr16:4500122 C/T cg08645402 chr16:4508243 NA 0.5 8.42 0.46 2.44e-15 Schizophrenia; CESC cis rs3106136 0.967 rs61514245 chr4:95165053 C/G cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.81 -0.39 6.69e-11 Capecitabine sensitivity; CESC cis rs3749237 0.576 rs4241406 chr3:49600426 C/T cg06212747 chr3:49208901 KLHDC8B 0.48 6.46 0.37 4.88e-10 Resting heart rate; CESC cis rs2249694 0.960 rs4351776 chr10:135415572 G/T cg20169779 chr10:135381914 SYCE1 -0.39 -5.58 -0.32 5.82e-8 Obesity-related traits; CESC cis rs7666738 0.606 rs6839946 chr4:99076132 A/C cg24818145 chr4:99064322 C4orf37 0.4 5.2 0.3 3.98e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.75 0.33 2.41e-8 Menopause (age at onset); CESC cis rs9911578 0.874 rs302874 chr17:56767996 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.08 -0.4 1.29e-11 Intelligence (multi-trait analysis); CESC cis rs9811920 0.609 rs17174947 chr3:99598884 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg01017244 chr2:74357527 NA 0.66 9.58 0.51 7.55e-19 Gestational age at birth (maternal effect); CESC cis rs11645898 0.935 rs72787091 chr16:72190184 C/T cg14768367 chr16:72042858 DHODH -0.79 -6.58 -0.37 2.51e-10 Blood protein levels; CESC cis rs7296418 0.699 rs11608297 chr12:123826642 T/C cg05973401 chr12:123451056 ABCB9 0.42 5.35 0.31 1.91e-7 Platelet count; CESC cis rs643506 0.874 rs687152 chr11:111721673 T/C cg17089665 chr11:111648010 NA -0.36 -5.2 -0.3 4.07e-7 Breast cancer; CESC trans rs5769765 0.819 rs9616379 chr22:50312035 C/T cg09872104 chr7:134855509 C7orf49 -0.55 -6.27 -0.36 1.47e-9 Schizophrenia; CESC cis rs10870270 0.957 rs10870307 chr10:133780610 T/C cg17892150 chr10:133769511 PPP2R2D -0.85 -12.37 -0.61 4.7e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7605827 0.930 rs4410258 chr2:15594984 A/C cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg05368731 chr17:41323189 NBR1 0.53 7.4 0.41 1.86e-12 Menopause (age at onset); CESC cis rs7671266 0.616 rs4320137 chr4:10072969 C/T cg00071950 chr4:10020882 SLC2A9 0.58 5.71 0.33 2.95e-8 Cardiovascular disease risk factors; CESC cis rs3796352 1.000 rs11710292 chr3:53117798 T/C cg12962167 chr3:53033115 SFMBT1 0.68 5.89 0.34 1.18e-8 Immune reponse to smallpox (secreted IL-2); CESC trans rs60843830 0.928 rs2306060 chr2:230912 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 8.53 0.46 1.11e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg27286337 chr10:134555280 INPP5A 0.58 6.83 0.39 5.92e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4074961 0.669 rs4652964 chr1:38078300 A/G cg13401533 chr1:37979913 MEAF6 0.52 7.04 0.4 1.61e-11 Axial length; CESC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1729951 0.575 rs1682356 chr3:136692037 T/C cg04103450 chr3:136751342 NA 0.41 5.48 0.32 9.91e-8 Neuroticism; CESC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg17372223 chr3:52568218 NT5DC2 0.39 5.91 0.34 1.02e-8 Electroencephalogram traits; CESC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg01206211 chr2:36825736 FEZ2 0.34 5.77 0.33 2.2e-8 Height; CESC cis rs9581857 0.556 rs1885990 chr13:28040502 C/T cg22138327 chr13:27999177 GTF3A 0.6 6.69 0.38 1.33e-10 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg27478167 chr7:817139 HEATR2 -0.47 -5.34 -0.31 1.98e-7 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23037648 chr3:101568246 NFKBIZ 0.57 6.22 0.36 1.92e-9 Gut microbiome composition (summer); CESC cis rs11676348 0.818 rs7423433 chr2:218985084 G/A cg00012203 chr2:219082015 ARPC2 -0.56 -7.31 -0.41 3.18e-12 Ulcerative colitis; CESC cis rs7592578 0.679 rs62181019 chr2:191325414 A/G cg10560079 chr2:191398806 TMEM194B -0.54 -5.35 -0.31 1.95e-7 Diastolic blood pressure; CESC cis rs965469 0.895 rs6051844 chr20:3402674 G/T cg25506879 chr20:3388711 C20orf194 0.55 6.1 0.35 3.65e-9 IFN-related cytopenia; CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg07092213 chr7:1199455 ZFAND2A -0.54 -6.26 -0.36 1.5e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10381409 chr21:37692231 MORC3 0.47 6.13 0.35 3.2e-9 Systemic lupus erythematosus; CESC cis rs3857067 1.000 rs6532462 chr4:95026833 G/T cg11021082 chr4:95130006 SMARCAD1 -0.53 -8.12 -0.45 1.77e-14 QT interval; CESC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg22029157 chr1:209979665 IRF6 -0.69 -9.77 -0.51 1.91e-19 Cleft lip with or without cleft palate; CESC cis rs6137287 0.643 rs6047259 chr20:21098319 A/G cg13880779 chr20:21376337 NKX2-4 -0.34 -5.51 -0.32 8.6e-8 Height; CESC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.65e-39 Menopause (age at onset); CESC cis rs11997175 1.000 rs6468201 chr8:33746854 G/C ch.8.33884649F chr8:33765107 NA 0.64 8.39 0.46 3.03e-15 Body mass index; CESC cis rs4604732 0.588 rs6677477 chr1:247629411 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.47 5.82 0.34 1.73e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7809950 1.000 rs3801954 chr7:107117048 C/T cg23024343 chr7:107201750 COG5 -0.43 -6.04 -0.35 5.27e-9 Coronary artery disease; CESC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg10053473 chr17:62856997 LRRC37A3 -0.67 -9.43 -0.5 2.21e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs2018683 0.834 rs2012754 chr7:29026257 G/A cg19402173 chr7:128379420 CALU -0.63 -7.85 -0.43 1e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs9443645 0.527 rs9343861 chr6:79744868 C/A cg05283184 chr6:79620031 NA -0.38 -5.42 -0.32 1.35e-7 Intelligence (multi-trait analysis); CESC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg07308232 chr7:1071921 C7orf50 -0.48 -6.83 -0.39 5.66e-11 Longevity;Endometriosis; CESC cis rs4253772 0.744 rs9627278 chr22:46643432 C/G cg09491104 chr22:46646882 C22orf40 -0.43 -5.8 -0.34 1.9e-8 LDL cholesterol;Cholesterol, total; CESC cis rs2295359 0.892 rs72676069 chr1:67658954 T/C cg17031739 chr1:67600172 NA 0.4 5.19 0.3 4.15e-7 Psoriasis; CESC cis rs7474896 0.559 rs1208560 chr10:38221618 A/T cg00409905 chr10:38381863 ZNF37A 0.45 5.08 0.3 7.06e-7 Obesity (extreme); CESC trans rs61931739 0.517 rs11052964 chr12:34010996 G/C cg26384229 chr12:38710491 ALG10B 0.58 8.06 0.44 2.68e-14 Morning vs. evening chronotype; CESC cis rs11583043 0.958 rs12746722 chr1:101464789 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.53 5.89 0.34 1.17e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs10751667 0.666 rs7395267 chr11:962326 C/A cg20946044 chr11:1010712 AP2A2 -0.38 -5.35 -0.31 1.92e-7 Alzheimer's disease (late onset); CESC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg09365446 chr1:150670422 GOLPH3L 0.38 5.13 0.3 5.74e-7 Melanoma; CESC cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg20307385 chr11:47447363 PSMC3 -0.62 -7.67 -0.43 3.34e-13 Subjective well-being; CESC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg17724175 chr1:150552817 MCL1 0.33 5.15 0.3 5.17e-7 Melanoma; CESC cis rs2243480 1.000 rs2257790 chr7:65600450 C/T cg12463550 chr7:65579703 CRCP 0.74 5.87 0.34 1.29e-8 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03416154 chr22:21336337 LZTR1 0.61 7.05 0.4 1.58e-11 Gut microbiome composition (summer); CESC cis rs6089584 0.606 rs2273989 chr20:60579138 G/A cg06108461 chr20:60628389 TAF4 -0.56 -7.3 -0.41 3.27e-12 Body mass index; CESC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg00074818 chr8:8560427 CLDN23 0.34 5.05 0.3 8.3e-7 Obesity-related traits; CESC cis rs11642862 1.000 rs11645175 chr16:30803299 C/T cg02466173 chr16:30829666 NA -0.59 -5.92 -0.34 9.76e-9 Tonsillectomy; CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg18538332 chr22:24372958 LOC391322 0.77 11.26 0.57 2.6e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs2207136 0.868 rs1157986 chr6:50843329 C/T cg06522515 chr3:184090630 THPO -0.38 -6.64 -0.38 1.77e-10 Myopia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17461271 chr1:172717683 NA 0.45 6.02 0.35 5.77e-9 Fibrinogen levels; CESC cis rs9910055 0.529 rs228766 chr17:42186813 A/G cg19774624 chr17:42201019 HDAC5 0.58 7.7 0.43 2.63e-13 Total body bone mineral density; CESC trans rs13360092 1.000 rs13358049 chr5:50542459 C/T cg03200537 chr16:87022121 NA 0.69 6.01 0.35 6.12e-9 Verbal declarative memory; CESC cis rs6912958 0.754 rs6918909 chr6:88247251 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.7 -0.38 1.24e-10 Monocyte percentage of white cells; CESC cis rs4308124 0.708 rs6747657 chr2:112003163 C/T cg04571233 chr2:111982156 NA -0.56 -6.31 -0.36 1.16e-9 Vitiligo; CESC cis rs7512552 0.839 rs1103115 chr1:150332304 G/A cg15654264 chr1:150340011 RPRD2 0.39 5.24 0.31 3.25e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg18512352 chr11:47633146 NA -0.5 -7.28 -0.41 3.85e-12 Subjective well-being; CESC trans rs10820912 0.673 rs4743861 chr9:92885650 T/A cg23943268 chr13:33589621 KL -0.47 -6.03 -0.35 5.55e-9 Left atrial antero-posterior diameter; CESC cis rs12956009 0.518 rs1560902 chr18:44898765 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.49 0.37 4.11e-10 Educational attainment (years of education); CESC cis rs7254114 0.568 rs8111456 chr19:11301147 A/G cg02815516 chr19:11306319 KANK2 -0.34 -5.46 -0.32 1.12e-7 Immature fraction of reticulocytes; CESC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg08027265 chr7:2291960 NA -0.42 -6.49 -0.37 4.13e-10 Schizophrenia; CESC cis rs7264396 0.790 rs3787168 chr20:34233278 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.94 -0.59 1.44e-26 Total cholesterol levels; CESC cis rs9913156 0.793 rs72835644 chr17:4573667 G/A cg00122941 chr17:4613640 ARRB2 0.88 10.3 0.53 3.7e-21 Lymphocyte counts; CESC cis rs8044868 0.548 rs3909541 chr16:72201119 C/T cg01557791 chr16:72042693 DHODH 0.39 5.21 0.3 3.81e-7 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs1348850 0.874 rs952746 chr2:178306584 A/G cg23306229 chr2:178417860 TTC30B 0.62 7.91 0.44 6.82e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7249921 0.833 rs59975720 chr19:35660954 G/A cg15419183 chr19:35660584 FXYD5 0.56 8.36 0.46 3.57e-15 Platelet count; CESC cis rs3812831 0.669 rs382913 chr13:114928255 G/T cg08824895 chr13:115047677 UPF3A 0.39 5.17 0.3 4.53e-7 Schizophrenia; CESC trans rs728996 0.560 rs2094260 chr6:51644687 G/A cg15101985 chr10:85961501 PCDH21 -0.46 -6.0 -0.35 6.4e-9 Weight loss (gastric bypass surgery); CESC cis rs11249608 0.548 rs6601007 chr5:178455796 G/C cg21905437 chr5:178450457 ZNF879 0.6 8.73 0.47 2.84e-16 Pubertal anthropometrics; CESC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC cis rs1707322 0.650 rs4553239 chr1:46150486 C/A cg06784218 chr1:46089804 CCDC17 0.43 7.6 0.42 5.22e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg18084450 chr1:235530719 TBCE 0.49 6.05 0.35 5.05e-9 Retinol levels; CESC cis rs6429082 0.818 rs834198 chr1:235671987 A/G cg26050004 chr1:235667680 B3GALNT2 0.66 8.09 0.44 2.18e-14 Adiposity; CESC cis rs6987853 0.787 rs2974346 chr8:42401205 T/C cg09913449 chr8:42400586 C8orf40 0.45 7.63 0.42 4.28e-13 Mean corpuscular hemoglobin concentration; CESC cis rs7772486 0.790 rs9376971 chr6:146259505 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -13.3 -0.63 2.94e-31 Lobe attachment (rater-scored or self-reported); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04125625 chr1:29564120 PTPRU -0.45 -6.0 -0.35 6.38e-9 Asthma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21302562 chr1:44497012 SLC6A9 -0.44 -6.34 -0.36 9.81e-10 Gambling; CESC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg13206674 chr6:150067644 NUP43 0.4 5.72 0.33 2.83e-8 Lung cancer; CESC cis rs34779708 0.931 rs11010132 chr10:35517265 C/G cg04310649 chr10:35416472 CREM -0.5 -6.05 -0.35 5e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg09555818 chr19:45449301 APOC2 0.41 6.55 0.37 3.05e-10 Blood protein levels; CESC cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg06634786 chr22:41940651 POLR3H -0.57 -5.84 -0.34 1.49e-8 Vitiligo; CESC cis rs4595586 0.545 rs12823721 chr12:39386461 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs9325144 0.602 rs11169100 chr12:39077861 G/T cg26384229 chr12:38710491 ALG10B -0.51 -6.98 -0.39 2.34e-11 Morning vs. evening chronotype; CESC cis rs7336332 0.598 rs10220056 chr13:28003781 T/G cg01674679 chr13:27998804 GTF3A -0.59 -5.34 -0.31 1.98e-7 Weight; CESC cis rs6500395 0.928 rs7199206 chr16:48702538 A/G cg04672837 chr16:48644449 N4BP1 -0.5 -6.2 -0.36 2.19e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12768767 chr1:47779966 STIL 0.61 6.61 0.38 2.05e-10 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.7 -0.55 1.91e-22 Alzheimer's disease; CESC cis rs1808579 0.874 rs1367083 chr18:21100240 C/T cg14672496 chr18:21087552 C18orf8 0.45 6.56 0.37 2.82e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs7662987 0.517 rs2602865 chr4:100034841 T/C cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC trans rs7618501 0.633 rs4688758 chr3:50028385 G/A cg21659725 chr3:3221576 CRBN 0.54 7.55 0.42 7.09e-13 Intelligence (multi-trait analysis); CESC cis rs12900413 0.562 rs28450767 chr15:90298228 A/G cg24249390 chr15:90295951 MESP1 -0.38 -5.14 -0.3 5.46e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs1008375 1.000 rs56308330 chr4:17643050 G/A cg16339924 chr4:17578868 LAP3 0.57 7.13 0.4 9.66e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2228479 0.702 rs62053701 chr16:89860584 G/A cg14709524 chr16:89940631 TCF25 0.93 6.97 0.39 2.5e-11 Skin colour saturation; CESC cis rs4699052 0.963 rs2061646 chr4:104183894 T/C cg16532752 chr4:104119610 CENPE -0.44 -5.98 -0.34 7.17e-9 Testicular germ cell tumor; CESC cis rs11098499 1.000 rs10029750 chr4:120172543 A/G cg24375607 chr4:120327624 NA 0.43 5.24 0.31 3.34e-7 Corneal astigmatism; CESC cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg14416269 chr4:6271139 WFS1 0.42 6.5 0.37 4e-10 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg16339924 chr4:17578868 LAP3 0.64 8.12 0.45 1.73e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.81 0.43 1.33e-13 Prudent dietary pattern; CESC cis rs6121246 0.580 rs6121016 chr20:30245239 C/T cg13852791 chr20:30311386 BCL2L1 0.81 8.59 0.47 7.37e-16 Mean corpuscular hemoglobin; CESC cis rs10200159 1.000 rs10200159 chr2:55845109 T/C cg13617705 chr2:55845095 SMEK2 0.74 5.34 0.31 2e-7 Vitiligo; CESC cis rs11078597 0.731 rs34962442 chr17:1640529 C/T cg18436246 chr17:1640651 WDR81 0.63 7.63 0.42 4.3e-13 Serum albumin level; CESC cis rs9291683 0.588 rs35866697 chr4:10018604 C/A cg00071950 chr4:10020882 SLC2A9 0.9 16.87 0.72 7.08e-44 Bone mineral density; CESC cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg10523679 chr1:76189770 ACADM 0.68 7.81 0.43 1.32e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg17971929 chr21:40555470 PSMG1 -0.6 -8.02 -0.44 3.31e-14 Menarche (age at onset); CESC cis rs208515 0.525 rs9453538 chr6:66668508 G/A cg07460842 chr6:66804631 NA 0.83 10.33 0.54 3.09e-21 Exhaled nitric oxide levels; CESC cis rs820218 0.847 rs1661745 chr17:73647139 A/G cg01592526 chr17:73663357 RECQL5;SAP30BP 0.43 5.79 0.33 2.02e-8 Rotator cuff tears; CESC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg07952391 chr2:88470173 THNSL2 0.63 6.02 0.35 5.73e-9 Plasma clusterin levels; CESC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg02099474 chr7:1027990 CYP2W1 -0.38 -5.63 -0.33 4.51e-8 Longevity;Endometriosis; CESC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs2243480 1.000 rs6966322 chr7:65646754 A/G cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.24e-32 Diabetic kidney disease; CESC cis rs854765 0.654 rs9911281 chr17:17762457 G/C cg16928487 chr17:17741425 SREBF1 0.55 9.61 0.51 6.15e-19 Total body bone mineral density; CESC cis rs4319547 0.615 rs2341439 chr12:122848096 C/G cg05707623 chr12:122985044 ZCCHC8 -0.53 -6.15 -0.35 2.77e-9 Body mass index; CESC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg05025164 chr4:1340916 KIAA1530 0.7 9.56 0.51 8.45e-19 Longevity; CESC cis rs27434 0.605 rs12659825 chr5:96188083 T/C cg16492584 chr5:96139282 ERAP1 0.53 6.35 0.36 9.22e-10 Ankylosing spondylitis; CESC cis rs4555082 0.874 rs1882846 chr14:105717448 G/C cg06808227 chr14:105710500 BRF1 -0.57 -6.58 -0.37 2.49e-10 Mean platelet volume;Platelet distribution width; CESC cis rs2479724 0.875 rs2253961 chr6:41827011 A/G cg08135965 chr6:41755394 TOMM6 0.41 5.5 0.32 8.74e-8 Menarche (age at onset); CESC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg09359103 chr1:154839909 KCNN3 -0.69 -13.25 -0.63 4.3e-31 Prostate cancer; CESC cis rs2294693 0.945 rs9381023 chr6:40983281 C/T cg14769373 chr6:40998127 UNC5CL 0.46 6.07 0.35 4.32e-9 Gastric cancer;Non-cardia gastric cancer; CESC cis rs9858542 0.953 rs9841110 chr3:49492481 C/G cg03060546 chr3:49711283 APEH -0.53 -6.04 -0.35 5.21e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs12142240 0.659 rs72677602 chr1:46837487 G/A cg00530320 chr1:46809349 NSUN4 0.62 7.96 0.44 4.98e-14 Menopause (age at onset); CESC cis rs7249142 0.562 rs10417796 chr19:19287072 A/G cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.28 5.12 0.3 5.98e-7 IgG glycosylation; CESC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg23758822 chr17:41437982 NA 1.04 15.72 0.69 8.63e-40 Menopause (age at onset); CESC cis rs17826219 0.706 rs57698184 chr17:29064918 T/C cg13385521 chr17:29058706 SUZ12P 0.82 6.62 0.38 2.04e-10 Body mass index; CESC cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg15017067 chr4:17643749 FAM184B 0.38 5.4 0.31 1.49e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.77 9.4 0.5 2.67e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg11941060 chr3:133502564 NA -0.51 -6.62 -0.38 1.96e-10 Iron status biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16401850 chr14:106445160 NA -0.49 -6.1 -0.35 3.82e-9 Gut microbiome composition (summer); CESC cis rs7264396 0.747 rs6058291 chr20:34247769 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 3.14e-26 Total cholesterol levels; CESC cis rs2952156 0.920 rs9303274 chr17:37836353 T/C cg19468946 chr17:37922297 IKZF3 -0.39 -5.03 -0.3 8.93e-7 Asthma; CESC trans rs2832077 0.527 rs9981922 chr21:30212718 A/G cg14791747 chr16:20752902 THUMPD1 0.53 7.51 0.42 8.86e-13 Cognitive test performance; CESC cis rs7116495 1.000 rs116781589 chr11:71825006 G/T cg26138937 chr11:71823887 C11orf51 0.85 6.86 0.39 4.92e-11 Severe influenza A (H1N1) infection; CESC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg22963979 chr7:1858916 MAD1L1 -0.37 -5.1 -0.3 6.41e-7 Bipolar disorder and schizophrenia; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg15759889 chr19:17420039 DDA1 -0.49 -6.5 -0.37 3.92e-10 Thyroid stimulating hormone; CESC cis rs6662572 0.737 rs4557909 chr1:46316949 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.04 -0.3 8.65e-7 Blood protein levels; CESC cis rs4891159 0.790 rs10514217 chr18:74144939 A/G cg24786174 chr18:74118243 ZNF516 -0.51 -6.38 -0.36 7.99e-10 Longevity; CESC cis rs6499255 0.951 rs8046314 chr16:69697922 T/A cg15192750 chr16:69999425 NA 0.46 5.34 0.31 2.04e-7 IgE levels; CESC cis rs6964587 0.626 rs409 chr7:91556355 C/T cg17063962 chr7:91808500 NA 0.45 6.33 0.36 1.07e-9 Breast cancer; CESC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg23048001 chr7:2026167 MAD1L1 0.4 5.22 0.31 3.68e-7 Bipolar disorder and schizophrenia; CESC cis rs6500395 0.963 rs2883642 chr16:48685146 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs8017423 0.536 rs11625794 chr14:90811229 C/T cg14092571 chr14:90743983 NA -0.4 -5.87 -0.34 1.31e-8 Mortality in heart failure; CESC cis rs7914558 1.000 rs7094843 chr10:104806654 A/C cg04362960 chr10:104952993 NT5C2 0.47 6.32 0.36 1.11e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs854765 0.547 rs2955378 chr17:17930253 G/A cg04398451 chr17:18023971 MYO15A -0.71 -10.32 -0.54 3.19e-21 Total body bone mineral density; CESC cis rs1707322 1.000 rs785478 chr1:46491635 C/T cg03146154 chr1:46216737 IPP -0.72 -9.87 -0.52 8.94e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1552244 0.554 rs17050705 chr3:10046398 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 7.99 0.44 4.24e-14 Alzheimer's disease; CESC cis rs2228479 0.850 rs11648433 chr16:89965055 G/A cg14709524 chr16:89940631 TCF25 0.86 6.25 0.36 1.66e-9 Skin colour saturation; CESC cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg17366294 chr4:99064904 C4orf37 0.56 7.52 0.42 8.37e-13 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.707 rs11078903 chr17:37631924 G/A cg20243544 chr17:37824526 PNMT 0.51 6.44 0.37 5.65e-10 Glomerular filtration rate (creatinine); CESC cis rs6565681 0.943 rs6565683 chr17:78362300 A/T cg15383979 chr17:78362278 RNF213;LOC100294362 -0.77 -8.66 -0.47 4.67e-16 Moyamoya disease; CESC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg02569458 chr12:86230093 RASSF9 0.49 7.68 0.43 3.04e-13 Major depressive disorder; CESC cis rs10979 1.000 rs9321923 chr6:143897206 A/G cg25407410 chr6:143891975 LOC285740 -0.6 -9.13 -0.49 1.8e-17 Hypospadias; CESC cis rs1681630 0.545 rs1228001 chr11:47986994 A/T cg18512352 chr11:47633146 NA -0.33 -5.22 -0.31 3.55e-7 Height; CESC cis rs2439831 1.000 rs2444250 chr15:43785051 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.25 0.53 5.49e-21 Lung cancer in ever smokers; CESC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg26338869 chr17:61819248 STRADA 0.67 8.66 0.47 4.55e-16 Prudent dietary pattern; CESC trans rs1606974 0.649 rs1028145 chr2:51928042 G/T cg21066735 chr11:15671806 NA -0.74 -6.14 -0.35 3.07e-9 Educational attainment (years of education);Educational attainment; CESC cis rs4450798 0.649 rs7631252 chr3:13803506 C/T cg23332027 chr3:13681764 NA 0.4 5.75 0.33 2.45e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs3733585 0.699 rs6449178 chr4:9968684 A/G cg00071950 chr4:10020882 SLC2A9 0.67 10.82 0.55 7.57e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7186908 1.000 rs7186908 chr16:72220373 G/C cg01557791 chr16:72042693 DHODH -0.69 -7.16 -0.4 7.73e-12 Liver enzyme levels (alkaline phosphatase); CESC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg00310523 chr12:86230176 RASSF9 0.36 5.63 0.33 4.6e-8 Major depressive disorder; CESC cis rs7917772 0.565 rs61869210 chr10:104437175 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.52 5.91 0.34 1.07e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6456156 0.586 rs7742305 chr6:167485723 C/T cg07741184 chr6:167504864 NA 0.37 6.28 0.36 1.39e-9 Primary biliary cholangitis; CESC cis rs854765 0.583 rs9904163 chr17:17830553 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.28 0.41 3.9e-12 Total body bone mineral density; CESC cis rs2997447 0.846 rs3008414 chr1:26404747 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.06 0.3 7.88e-7 QRS complex (12-leadsum); CESC cis rs796364 0.951 rs7608668 chr2:201000017 T/C cg23649088 chr2:200775458 C2orf69 -0.56 -5.79 -0.34 2.01e-8 Schizophrenia; CESC cis rs1178968 1.000 rs1178969 chr7:72759114 A/G cg25889504 chr7:72793014 NA 0.52 5.47 0.32 1.03e-7 Triglyceride levels; CESC cis rs1957429 0.808 rs1467573 chr14:65347583 T/C cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC cis rs8008758 1.000 rs12435364 chr14:101690209 G/A cg26224664 chr14:101693935 NA -0.35 -5.33 -0.31 2.07e-7 Body mass index (alcohol intake interaction); CESC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg07414643 chr4:187882934 NA 0.54 7.67 0.43 3.32e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12189382 chr17:79077463 BAIAP2 0.44 6.49 0.37 4.3e-10 Fibrinogen levels; CESC cis rs2075371 0.611 rs12707154 chr7:134015832 C/T cg11752832 chr7:134001865 SLC35B4 0.43 5.22 0.31 3.58e-7 Mean platelet volume; CESC trans rs7937682 0.889 rs516263 chr11:111484719 A/C cg18187862 chr3:45730750 SACM1L 0.48 6.05 0.35 4.86e-9 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13057098 chr11:49873813 NA -0.49 -6.05 -0.35 4.95e-9 Gut microbiome composition (summer); CESC cis rs6693567 0.565 rs1260457 chr1:150347374 G/A cg09579323 chr1:150459698 TARS2 0.48 6.12 0.35 3.27e-9 Migraine; CESC cis rs9400271 0.609 rs9386783 chr6:109588644 G/T cg01475377 chr6:109611718 NA -0.46 -7.18 -0.4 7.24e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs7264396 0.790 rs6060541 chr20:34248066 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.77 0.43 1.78e-13 Total cholesterol levels; CESC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -5.13 -0.3 5.7e-7 Tonsillectomy; CESC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg03396347 chr1:1875803 NA -0.44 -6.79 -0.39 7.14e-11 Body mass index; CESC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg19468946 chr17:37922297 IKZF3 0.42 5.48 0.32 9.97e-8 Glomerular filtration rate (creatinine); CESC cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg24642439 chr20:33292090 TP53INP2 0.71 9.39 0.5 2.91e-18 Coronary artery disease; CESC cis rs5758659 0.652 rs5758537 chr22:42397042 G/T cg04733989 chr22:42467013 NAGA 0.44 5.82 0.34 1.71e-8 Cognitive function; CESC cis rs7927592 0.913 rs7118897 chr11:68360680 G/A cg16797656 chr11:68205561 LRP5 0.38 5.42 0.32 1.35e-7 Total body bone mineral density; CESC cis rs2832191 0.511 rs7278227 chr21:30482707 C/T cg08807101 chr21:30365312 RNF160 -0.53 -6.8 -0.39 6.89e-11 Dental caries; CESC cis rs727505 1.000 rs113394869 chr7:124518172 G/C cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs1218582 0.688 rs58629129 chr1:154910930 T/C cg16680214 chr1:154839983 KCNN3 -0.45 -6.77 -0.38 8.23e-11 Prostate cancer; CESC cis rs3820068 0.603 rs59558854 chr1:15971399 T/G cg16988262 chr1:15930761 NA 0.33 5.41 0.32 1.44e-7 Systolic blood pressure; CESC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg18240062 chr17:79603768 NPLOC4 0.72 10.27 0.53 4.71e-21 Eye color traits; CESC cis rs854765 0.547 rs2955353 chr17:17948979 T/C cg16928487 chr17:17741425 SREBF1 0.55 9.13 0.49 1.86e-17 Total body bone mineral density; CESC trans rs17685 0.712 rs10235738 chr7:75773460 G/A cg19862616 chr7:65841803 NCRNA00174 0.8 11.44 0.57 6.89e-25 Coffee consumption;Coffee consumption (cups per day); CESC cis rs929596 0.755 rs887829 chr2:234668570 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.65 8.45 0.46 1.9e-15 Total bilirubin levels in HIV-1 infection; CESC trans rs60843830 1.000 rs2290911 chr2:224919 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 8.25 0.45 7.47e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs559928 0.597 rs2096706 chr11:63924446 T/G cg18225595 chr11:63971243 STIP1 0.67 5.9 0.34 1.1e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs4728302 0.869 rs7805864 chr7:133610390 G/A cg10665199 chr7:133106180 EXOC4 0.4 5.61 0.33 4.98e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7208859 0.673 rs216410 chr17:28903831 C/G cg14008862 chr17:28927542 LRRC37B2 -0.54 -5.29 -0.31 2.59e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9929218 0.953 rs2902323 chr16:68736292 C/T cg02972257 chr16:68554789 NA 0.58 6.47 0.37 4.74e-10 Colorectal cancer; CESC trans rs459571 0.959 rs2073818 chr9:136918662 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.65 -8.5 -0.46 1.43e-15 Platelet distribution width; CESC cis rs2066819 1.000 rs58852079 chr12:56706922 A/C cg26804944 chr12:56660921 COQ10A -0.85 -5.14 -0.3 5.39e-7 Psoriasis vulgaris; CESC cis rs2777491 0.957 rs16971798 chr15:41657144 A/T cg20272979 chr15:41787780 ITPKA -0.36 -5.28 -0.31 2.73e-7 Ulcerative colitis; CESC cis rs2115630 0.645 rs6496284 chr15:85178270 A/G cg12501888 chr15:85177176 SCAND2 -0.5 -6.48 -0.37 4.53e-10 P wave terminal force; CESC cis rs12142240 0.698 rs72677593 chr1:46824363 T/C cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs6088580 0.634 rs6087580 chr20:32992592 A/G cg24642439 chr20:33292090 TP53INP2 -0.55 -7.36 -0.41 2.32e-12 Glomerular filtration rate (creatinine); CESC cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg17971929 chr21:40555470 PSMG1 0.59 7.61 0.42 4.8e-13 Cognitive function; CESC cis rs2455799 0.573 rs2455829 chr3:15746937 G/A cg16303742 chr3:15540471 COLQ -0.36 -5.42 -0.32 1.33e-7 Mean platelet volume; CESC cis rs9788721 0.592 rs28564957 chr15:78906107 C/A cg06917634 chr15:78832804 PSMA4 -0.55 -7.31 -0.41 3.14e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CESC cis rs736408 0.677 rs678 chr3:52820981 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.03 0.3 8.98e-7 Bipolar disorder; CESC cis rs7208859 0.725 rs9897673 chr17:29243366 T/C cg19761014 chr17:28927070 LRRC37B2 0.66 6.17 0.35 2.57e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs561341 1.000 rs548957 chr17:30302411 G/A cg19193384 chr17:30244184 NA -0.67 -6.36 -0.36 8.74e-10 Hip circumference adjusted for BMI; CESC cis rs2760061 0.626 rs2313118 chr1:228118084 T/C cg01973587 chr1:228161476 NA 0.35 5.31 0.31 2.3e-7 Diastolic blood pressure; CESC cis rs96067 0.740 rs10752586 chr1:36614713 C/G cg24686825 chr1:36642396 MAP7D1 -0.49 -5.59 -0.32 5.73e-8 Corneal structure; CESC cis rs6963495 0.818 rs818619 chr7:105172505 A/T cg13798780 chr7:105162888 PUS7 0.6 6.94 0.39 2.96e-11 Bipolar disorder (body mass index interaction); CESC cis rs10848704 0.525 rs4073984 chr12:2885780 G/A cg19995117 chr12:2880862 NA 0.5 7.7 0.43 2.72e-13 Quantitative traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11539992 chr17:74497631 RHBDF2 0.59 6.77 0.38 8.25e-11 Gut microbiome composition (summer); CESC cis rs9399135 0.967 rs2327580 chr6:135364417 A/C cg22676075 chr6:135203613 NA 0.51 7.29 0.41 3.64e-12 Red blood cell count; CESC cis rs3749237 1.000 rs11920900 chr3:49823024 G/C cg03060546 chr3:49711283 APEH 0.66 7.88 0.44 8.24e-14 Resting heart rate; CESC cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg11644478 chr21:40555479 PSMG1 0.7 10.21 0.53 7.41e-21 Cognitive function; CESC cis rs1697139 0.935 rs1625369 chr5:66513022 C/T cg11553311 chr5:66541588 NA 0.33 5.05 0.3 8.4e-7 Breast cancer; CESC cis rs748404 0.631 rs7167882 chr15:43678663 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.62 7.96 0.44 4.91e-14 Lung cancer; CESC cis rs2228479 0.850 rs62054638 chr16:89821131 G/C cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 6.37 0.36 8.43e-10 Personality dimensions; CESC cis rs847577 0.722 rs7790120 chr7:97712831 C/A cg21770322 chr7:97807741 LMTK2 0.64 10.58 0.55 4.59e-22 Breast cancer; CESC cis rs861020 0.630 rs616544 chr1:210007368 T/C cg05527609 chr1:210001259 C1orf107 0.74 9.67 0.51 3.97e-19 Orofacial clefts; CESC cis rs67311347 1.000 rs11715214 chr3:40403004 C/A cg09455208 chr3:40491958 NA 0.52 8.86 0.48 1.19e-16 Renal cell carcinoma; CESC cis rs3091242 0.900 rs1883427 chr1:25744468 C/T cg03538708 chr1:25844672 NA -0.41 -6.18 -0.36 2.39e-9 Erythrocyte sedimentation rate; CESC cis rs9443645 0.870 rs9350799 chr6:79723651 C/A cg05283184 chr6:79620031 NA -0.4 -6.25 -0.36 1.68e-9 Intelligence (multi-trait analysis); CESC cis rs6570726 1.000 rs444564 chr6:145859795 G/C cg05347473 chr6:146136440 FBXO30 0.43 5.78 0.33 2.1e-8 Lobe attachment (rater-scored or self-reported); CESC trans rs112591243 0.685 rs73379602 chr21:48027317 G/A cg21286782 chr1:113265602 FAM19A3 -0.61 -6.19 -0.36 2.31e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs3820068 0.705 rs58424111 chr1:15868470 A/C cg17385448 chr1:15911702 AGMAT 0.36 5.66 0.33 3.96e-8 Systolic blood pressure; CESC cis rs9393692 0.620 rs9379844 chr6:26291527 A/G cg13736514 chr6:26305472 NA 0.36 5.93 0.34 9.57e-9 Educational attainment; CESC cis rs77956314 0.515 rs7302025 chr12:117442902 C/T cg25972092 chr12:117363249 FBXW8 0.54 6.07 0.35 4.37e-9 Subcortical brain region volumes;Hippocampal volume; CESC cis rs3096299 0.606 rs4785674 chr16:89536613 A/G cg02034447 chr16:89574710 SPG7 0.43 5.04 0.3 8.68e-7 Multiple myeloma (IgH translocation); CESC cis rs10463316 0.894 rs6880137 chr5:150755232 A/G cg03212797 chr5:150827313 SLC36A1 -0.44 -5.75 -0.33 2.49e-8 Metabolite levels (Pyroglutamine); CESC cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg17366294 chr4:99064904 C4orf37 0.53 7.06 0.4 1.42e-11 Colonoscopy-negative controls vs population controls; CESC trans rs6934970 0.860 rs4515421 chr6:112980969 A/G cg05146922 chr2:10634174 NA -0.38 -6.18 -0.35 2.35e-9 Bipolar disorder (body mass index interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05826458 chr2:111875031 ACOXL -0.35 -6.05 -0.35 4.98e-9 Gambling; CESC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg04369109 chr6:150039330 LATS1 -0.37 -5.07 -0.3 7.56e-7 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00917603 chr5:140209956 PCDHA6;PCDHA2;PCDHA1;PCDHA5;PCDHA3;PCDHA4 -0.46 -6.07 -0.35 4.36e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.35 0.81 6.51e-63 Prudent dietary pattern; CESC cis rs57221529 0.766 rs4245972 chr5:578572 A/G cg16447950 chr5:562315 NA -0.64 -6.81 -0.39 6.59e-11 Lung disease severity in cystic fibrosis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26350446 chr7:111202682 IMMP2L -0.46 -6.38 -0.36 7.67e-10 Asthma; CESC cis rs763121 0.853 rs5757200 chr22:39043491 T/G cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs854765 0.551 rs6502626 chr17:17849450 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.65 9.29 0.5 5.8e-18 Total body bone mineral density; CESC cis rs11650494 0.908 rs9891264 chr17:47407342 T/A cg08112188 chr17:47440006 ZNF652 0.83 6.16 0.35 2.75e-9 Prostate cancer; CESC cis rs3096299 0.935 rs3102387 chr16:89432276 A/C cg16743903 chr16:89593216 SPG7 -0.41 -5.18 -0.3 4.33e-7 Multiple myeloma (IgH translocation); CESC cis rs1506636 0.927 rs11983604 chr7:123329754 T/G cg03229431 chr7:123269106 ASB15 -0.51 -6.79 -0.38 7.53e-11 Plateletcrit;Platelet count; CESC cis rs13266463 1.000 rs13266463 chr8:143403693 A/G cg06454464 chr8:143427921 TSNARE1 -0.38 -5.09 -0.3 6.9e-7 Schizophrenia; CESC cis rs9902453 0.934 rs4343336 chr17:28488236 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 8.08 0.44 2.37e-14 Coffee consumption (cups per day); CESC cis rs782590 0.935 rs6739513 chr2:55749902 G/A cg18811423 chr2:55921094 PNPT1 0.79 12.42 0.61 3.19e-28 Metabolic syndrome; CESC cis rs9560113 0.573 rs9560130 chr13:112229460 G/A cg10483660 chr13:112241077 NA 0.44 7.17 0.4 7.32e-12 Menarche (age at onset); CESC cis rs9329289 0.926 rs10903784 chr10:2541943 G/T cg18171855 chr10:2543474 NA -0.38 -5.84 -0.34 1.51e-8 Age-related hearing impairment; CESC cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg12193833 chr17:30244370 NA -0.75 -6.57 -0.37 2.6e-10 Hip circumference adjusted for BMI; CESC cis rs72781680 0.898 rs12614616 chr2:23996501 T/G cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs17376456 0.877 rs10055340 chr5:93317644 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.64 5.63 0.33 4.56e-8 Diabetic retinopathy; CESC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg09658497 chr7:2847517 GNA12 -0.42 -5.89 -0.34 1.17e-8 Height; CESC cis rs3008870 0.755 rs2815349 chr1:67472280 G/A cg02640540 chr1:67518911 SLC35D1 0.45 5.43 0.32 1.25e-7 Lymphocyte percentage of white cells; CESC cis rs76525880 0.538 rs7405452 chr17:46674670 A/G cg06593406 chr17:46696139 NA -0.62 -5.98 -0.34 7.22e-9 Colorectal or endometrial cancer; CESC cis rs763121 0.752 rs6001190 chr22:39073811 T/C cg06022373 chr22:39101656 GTPBP1 0.88 13.88 0.65 2.67e-33 Menopause (age at onset); CESC cis rs977987 0.836 rs34673655 chr16:75323559 T/C cg03315344 chr16:75512273 CHST6 0.37 5.35 0.31 1.94e-7 Dupuytren's disease; CESC cis rs7818345 0.935 rs4333618 chr8:19283442 G/C cg11303988 chr8:19266685 CSGALNACT1 0.35 6.42 0.37 6.42e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg04025307 chr7:1156635 C7orf50 0.55 9.69 0.51 3.39e-19 Longevity;Endometriosis; CESC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg16606324 chr3:10149918 C3orf24 0.42 5.2 0.3 4.02e-7 Alzheimer's disease; CESC cis rs854765 0.929 rs854766 chr17:18012775 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.44 5.74 0.33 2.54e-8 Total body bone mineral density; CESC cis rs561341 1.000 rs530209 chr17:30315287 A/G cg23018236 chr17:30244563 NA -0.52 -5.1 -0.3 6.39e-7 Hip circumference adjusted for BMI; CESC trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.5 0.46 1.36e-15 Intelligence (multi-trait analysis); CESC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg08499158 chr17:42289980 UBTF -0.62 -7.11 -0.4 1.07e-11 Total body bone mineral density; CESC cis rs11122272 0.735 rs2808603 chr1:231537738 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.47 -0.42 1.15e-12 Hemoglobin concentration; CESC cis rs1153858 0.848 rs9806699 chr15:45740392 G/A cg21132104 chr15:45694354 SPATA5L1 0.62 7.53 0.42 8.23e-13 Homoarginine levels; CESC cis rs9768139 0.733 rs10156158 chr7:158122287 G/T cg25566285 chr7:158114605 PTPRN2 0.51 8.46 0.46 1.77e-15 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11557382 chr7:153446256 NA -0.44 -6.44 -0.37 5.63e-10 Gut microbiome composition (summer); CESC cis rs9916302 0.660 rs4795367 chr17:37608843 G/C cg07936489 chr17:37558343 FBXL20 -0.91 -9.97 -0.52 4.37e-20 Glomerular filtration rate (creatinine); CESC trans rs561341 0.883 rs4450460 chr17:30201309 C/T cg20587970 chr11:113659929 NA 0.99 11.7 0.58 9.14e-26 Hip circumference adjusted for BMI; CESC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg00149659 chr3:10157352 C3orf10 0.75 9.44 0.5 2.06e-18 Alzheimer's disease; CESC cis rs2637266 0.703 rs1866889 chr10:78486389 A/G cg18941641 chr10:78392320 NA 0.4 7.67 0.43 3.3e-13 Pulmonary function; CESC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg02034447 chr16:89574710 SPG7 0.49 6.34 0.36 9.76e-10 Multiple myeloma (IgH translocation); CESC cis rs7267979 0.789 rs2260197 chr20:25284343 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.71 11.64 0.58 1.46e-25 Liver enzyme levels (alkaline phosphatase); CESC cis rs524023 0.914 rs2360872 chr11:64353405 T/C cg07220939 chr11:64358617 SLC22A12 -0.33 -5.14 -0.3 5.25e-7 Urate levels in obese individuals; CESC cis rs2735413 1.000 rs2735413 chr16:78053643 A/T cg04733911 chr16:78082701 NA -0.42 -6.24 -0.36 1.74e-9 Systolic blood pressure (alcohol consumption interaction); CESC cis rs2243480 1.000 rs316312 chr7:65596491 T/G cg12463550 chr7:65579703 CRCP 0.73 5.68 0.33 3.5e-8 Diabetic kidney disease; CESC cis rs727563 0.593 rs132770 chr22:42017264 A/G cg03806693 chr22:41940476 POLR3H 1.11 12.69 0.61 3.65e-29 Crohn's disease;Inflammatory bowel disease; CESC cis rs899997 1.000 rs4887078 chr15:79011073 C/T cg04896959 chr15:78267971 NA 0.42 6.38 0.36 7.95e-10 Coronary artery disease or large artery stroke; CESC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.84 9.13 0.49 1.82e-17 Platelet count; CESC cis rs3020736 0.500 rs6002604 chr22:42493081 A/T cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC cis rs4727963 0.740 rs1404834 chr7:122715112 A/T cg03640110 chr7:122635026 TAS2R16 0.4 6.43 0.37 6.01e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC trans rs1557351 0.723 rs9945715 chr18:54720377 T/C cg11433624 chr6:7146702 RREB1 0.38 6.12 0.35 3.34e-9 Multiple sclerosis (age of onset); CESC cis rs1348850 0.558 rs4337505 chr2:178529714 A/T cg23306229 chr2:178417860 TTC30B 0.47 5.56 0.32 6.7e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7845219 0.544 rs4735330 chr8:95917770 A/C cg09323728 chr8:95962352 TP53INP1 -0.32 -6.23 -0.36 1.8e-9 Type 2 diabetes; CESC cis rs7819412 0.594 rs7460507 chr8:10969075 C/T cg21775007 chr8:11205619 TDH -0.39 -5.6 -0.33 5.38e-8 Triglycerides; CESC cis rs7520050 0.807 rs6671802 chr1:46124663 A/G cg24296786 chr1:45957014 TESK2 -0.46 -5.96 -0.34 8.19e-9 Red blood cell count;Reticulocyte count; CESC cis rs8016982 0.632 rs8010219 chr14:81696982 A/G cg01989461 chr14:81687754 GTF2A1 0.47 5.33 0.31 2.11e-7 Schizophrenia; CESC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg06873352 chr17:61820015 STRADA 0.73 12.78 0.62 1.83e-29 Prudent dietary pattern; CESC cis rs9287719 0.967 rs3814388 chr2:10702099 A/T cg00105475 chr2:10696890 NA 0.39 5.71 0.33 3.1e-8 Prostate cancer; CESC cis rs6665290 0.669 rs3768421 chr1:227177193 G/A cg10327440 chr1:227177885 CDC42BPA -1.13 -24.36 -0.83 1.41e-69 Myeloid white cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26056348 chr7:75932317 HSPB1 0.54 6.63 0.38 1.91e-10 Gut microbiome composition (summer); CESC cis rs3087591 1.000 rs2057769 chr17:29691368 C/A cg24425628 chr17:29625626 OMG;NF1 -0.46 -5.75 -0.33 2.49e-8 Hip circumference; CESC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg07153921 chr17:41440717 NA -0.38 -5.15 -0.3 5.13e-7 Menopause (age at onset); CESC cis rs703842 0.616 rs1875125 chr12:58227241 T/G cg00677455 chr12:58241039 CTDSP2 0.73 9.87 0.52 9.2e-20 Multiple sclerosis; CESC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg22433210 chr17:43662623 NA 0.98 11.57 0.58 2.54e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg22535103 chr8:58192502 C8orf71 -0.94 -9.38 -0.5 3.05e-18 Developmental language disorder (linguistic errors); CESC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg23048001 chr7:2026167 MAD1L1 0.4 5.44 0.32 1.21e-7 Bipolar disorder and schizophrenia; CESC cis rs684232 0.602 rs35206514 chr17:519859 T/C cg12384639 chr17:618140 VPS53 0.43 5.51 0.32 8.37e-8 Prostate cancer; CESC cis rs6540556 0.954 rs6696463 chr1:209933757 G/C cg23920097 chr1:209922102 NA -0.37 -5.54 -0.32 7.2e-8 Red blood cell count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07136949 chr6:7986672 MGC26597 0.47 6.93 0.39 3.26e-11 Fibrinogen levels; CESC cis rs72781680 1.000 rs72781689 chr2:24256349 C/T cg20701182 chr2:24300061 SF3B14 0.99 8.48 0.46 1.64e-15 Lymphocyte counts; CESC cis rs533581 0.816 rs533406 chr16:88974860 A/G cg16701003 chr16:89028210 CBFA2T3 0.55 8.27 0.45 6.73e-15 Social autistic-like traits; CESC cis rs7927771 1.000 rs12419692 chr11:47624714 A/C cg18512352 chr11:47633146 NA 0.57 8.95 0.48 6.16e-17 Subjective well-being; CESC cis rs8103278 0.864 rs2070737 chr19:46282890 A/T cg12641515 chr19:46296257 DMWD -0.52 -5.88 -0.34 1.24e-8 Coronary artery disease; CESC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg26314531 chr2:26401878 FAM59B -0.83 -9.26 -0.49 7.29e-18 Gut microbiome composition (summer); CESC cis rs8060686 0.641 rs75297764 chr16:68212820 C/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.03 -0.35 5.55e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs397969 0.596 rs12450857 chr17:19895248 C/T cg12073167 chr17:19770448 ULK2 -0.46 -5.53 -0.32 7.6e-8 Platelet count; CESC cis rs4604732 0.631 rs1106721 chr1:247624676 A/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12579753 0.719 rs4418885 chr12:82275845 A/T cg23701643 chr12:82153290 PPFIA2 -0.37 -5.4 -0.31 1.48e-7 Resting heart rate; CESC cis rs9473147 0.543 rs4715019 chr6:47447041 T/A cg20196966 chr6:47445060 CD2AP 0.4 5.15 0.3 5.07e-7 Platelet distribution width;Mean platelet volume; CESC cis rs12791968 1.000 rs12791968 chr11:45001490 C/T cg11846598 chr11:44996168 LOC221122 0.54 7.17 0.4 7.54e-12 Inhibitory control; CESC cis rs9902453 0.933 rs9303628 chr17:28527228 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 8.2 0.45 1.03e-14 Coffee consumption (cups per day); CESC cis rs909674 0.514 rs7423 chr22:39781429 C/T cg02038168 chr22:39784481 NA -0.56 -7.46 -0.42 1.24e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7178572 0.568 rs11636554 chr15:77608747 C/T cg22256960 chr15:77711686 NA -0.53 -6.78 -0.38 7.59e-11 Type 2 diabetes; CESC cis rs7917772 0.503 rs7078435 chr10:104304766 T/C cg22532475 chr10:104410764 TRIM8 -0.34 -5.85 -0.34 1.43e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2380220 0.808 rs2613547 chr6:95910311 C/T cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs8072100 0.745 rs7214410 chr17:45422628 A/G cg25173405 chr17:45401733 C17orf57 -0.44 -5.72 -0.33 2.87e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2154427 0.511 rs7279487 chr21:34001824 T/C cg21871883 chr21:34145043 C21orf49;C21orf66 0.69 6.52 0.37 3.44e-10 Bilirubin levels; CESC cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg05283184 chr6:79620031 NA -0.41 -6.38 -0.36 7.79e-10 Intelligence (multi-trait analysis); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02269272 chr17:17991219 DRG2 0.46 6.28 0.36 1.4e-9 Systemic lupus erythematosus; CESC trans rs11722228 0.539 rs62287552 chr4:10153197 C/T cg26043149 chr18:55253948 FECH 0.99 12.72 0.62 3.02e-29 Gout;Urate levels;Serum uric acid levels; CESC cis rs11098499 0.874 rs13123591 chr4:120105990 T/G cg09307838 chr4:120376055 NA 0.67 8.17 0.45 1.26e-14 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13409575 chr2:63277708 OTX1 0.59 6.52 0.37 3.59e-10 Gut microbiome composition (summer); CESC cis rs7474896 0.537 rs598857 chr10:38302926 A/G cg25427524 chr10:38739819 LOC399744 0.49 5.56 0.32 6.5e-8 Obesity (extreme); CESC cis rs11997175 0.625 rs2882300 chr8:33585323 G/A ch.8.33884649F chr8:33765107 NA 0.55 6.97 0.39 2.55e-11 Body mass index; CESC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg19592336 chr6:28129416 ZNF389 0.54 7.17 0.4 7.59e-12 Parkinson's disease; CESC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg08027265 chr7:2291960 NA -0.34 -5.13 -0.3 5.68e-7 Bipolar disorder and schizophrenia; CESC trans rs208515 0.525 rs10944863 chr6:66676238 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.9 0.56 4.24e-23 Exhaled nitric oxide levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00762468 chr16:103568 POLR3K;SNRNP25 -0.45 -6.48 -0.37 4.37e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg13357178 chr17:41623362 ETV4 0.47 6.08 0.35 4.1e-9 Myopia (pathological); CESC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg23758822 chr17:41437982 NA 1.03 18.09 0.74 3.44e-48 Menopause (age at onset); CESC cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg06212747 chr3:49208901 KLHDC8B 0.68 7.95 0.44 5.47e-14 Menarche (age at onset); CESC cis rs11864453 0.826 rs12325142 chr16:72138112 G/T cg16558253 chr16:72132732 DHX38 -0.61 -9.79 -0.52 1.58e-19 Fibrinogen levels; CESC cis rs2835872 0.758 rs1787395 chr21:39036478 A/C cg06728970 chr21:39037746 KCNJ6 0.3 5.57 0.32 6.36e-8 Electroencephalographic traits in alcoholism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18313106 chr1:229694614 ABCB10 -0.43 -6.27 -0.36 1.46e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8062405 0.792 rs12446550 chr16:28543381 G/A cg07382826 chr16:28625726 SULT1A1 0.31 5.1 0.3 6.35e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2204008 0.683 rs12370288 chr12:38127740 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.6 0.38 2.21e-10 Bladder cancer; CESC cis rs1670533 1.000 rs10084890 chr4:1053934 C/G cg04106633 chr4:1044584 NA -0.41 -5.22 -0.31 3.7e-7 Recombination rate (females); CESC cis rs9910055 0.573 rs113184718 chr17:42206543 A/T cg08499158 chr17:42289980 UBTF 0.49 6.19 0.36 2.33e-9 Total body bone mineral density; CESC cis rs4835473 0.932 rs5015760 chr4:144659108 G/T cg25736465 chr4:144833511 NA -0.33 -5.31 -0.31 2.3e-7 Immature fraction of reticulocytes; CESC cis rs77861329 1.000 rs164639 chr3:52210872 A/G cg08692210 chr3:52188851 WDR51A -0.62 -6.62 -0.38 2.02e-10 Macrophage inflammatory protein 1b levels; CESC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.05e-8 Lung cancer; CESC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg22903471 chr2:27725779 GCKR -0.52 -7.38 -0.41 2.05e-12 Total body bone mineral density; CESC cis rs7666738 0.819 rs13120307 chr4:99036100 A/C cg17366294 chr4:99064904 C4orf37 0.62 8.62 0.47 6.05e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1348850 0.574 rs11889488 chr2:178426793 A/G cg22681709 chr2:178499509 PDE11A 0.49 5.04 0.3 8.66e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7267979 1.000 rs6050629 chr20:25430680 G/A cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.4e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs5769765 0.908 rs4824109 chr22:50271460 T/C cg26441486 chr22:50317300 CRELD2 -0.39 -5.33 -0.31 2.07e-7 Schizophrenia; CESC cis rs8103278 1.000 rs17571725 chr19:46290822 C/T cg11657440 chr19:46296263 DMWD -0.61 -7.75 -0.43 1.99e-13 Coronary artery disease; CESC cis rs8114671 0.836 rs2038504 chr20:33648187 T/C cg24642439 chr20:33292090 TP53INP2 -0.47 -5.71 -0.33 3.09e-8 Height; CESC cis rs1670533 1.000 rs6822863 chr4:1055606 G/A cg27284194 chr4:1044797 NA 0.47 6.01 0.35 6.16e-9 Recombination rate (females); CESC cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg02896835 chr1:92012615 NA -0.57 -6.63 -0.38 1.93e-10 Eosinophil percentage of white cells; CESC cis rs72945132 0.882 rs17160762 chr11:70134766 A/G cg00319359 chr11:70116639 PPFIA1 -0.77 -7.39 -0.41 1.98e-12 Coronary artery disease; CESC cis rs12291225 0.753 rs1431374 chr11:14303975 T/C cg19336497 chr11:14380999 RRAS2 -0.37 -5.28 -0.31 2.65e-7 Sense of smell; CESC cis rs7223966 1.000 rs8073373 chr17:61703320 T/C cg11494091 chr17:61959527 GH2 0.39 5.43 0.32 1.26e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs11718455 0.767 rs6771202 chr3:43990087 A/T cg08738300 chr3:44038990 NA 0.42 5.64 0.33 4.31e-8 Coronary artery disease; CESC cis rs597583 0.671 rs4938401 chr11:117399605 T/G cg27161313 chr11:117392002 DSCAML1 -0.53 -6.03 -0.35 5.47e-9 Putamen volume; CESC cis rs2361710 0.668 rs2304855 chr17:78118266 T/A cg06718696 chr17:78121285 EIF4A3 0.48 5.66 0.33 3.9e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CESC cis rs826838 0.935 rs980571 chr12:39127532 C/G cg13010199 chr12:38710504 ALG10B -0.44 -6.1 -0.35 3.81e-9 Heart rate; CESC cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg25208724 chr1:156163844 SLC25A44 1.01 18.98 0.76 2.67e-51 Testicular germ cell tumor; CESC trans rs7246657 0.882 rs8112610 chr19:37928730 C/A cg24637308 chr11:6592297 DNHD1 0.54 6.27 0.36 1.43e-9 Coronary artery calcification; CESC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg18135555 chr8:22132992 PIWIL2 -0.25 -5.52 -0.32 8.27e-8 Hypertriglyceridemia; CESC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg06420487 chr17:61919686 SMARCD2 0.46 5.52 0.32 8.21e-8 Height; CESC cis rs9309473 0.606 rs1589576 chr2:73738804 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -5.84 -0.34 1.5e-8 Metabolite levels; CESC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg07343612 chr16:622815 PIGQ -0.53 -7.72 -0.43 2.4e-13 Height; CESC cis rs7116495 0.881 rs615000 chr11:71802952 A/C cg26138937 chr11:71823887 C11orf51 -0.89 -7.22 -0.41 5.37e-12 Severe influenza A (H1N1) infection; CESC cis rs12618769 0.625 rs3769726 chr2:99105827 G/C cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs11792861 0.566 rs11792635 chr9:111848819 A/G cg05043794 chr9:111880884 C9orf5 -0.29 -5.13 -0.3 5.62e-7 Menarche (age at onset); CESC cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg05890377 chr2:74357713 NA 0.77 10.47 0.54 1.05e-21 Gestational age at birth (maternal effect); CESC cis rs7267979 1.000 rs2500443 chr20:25331442 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -16.43 -0.71 2.69e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs7772486 0.790 rs9791313 chr6:146266172 T/C cg23711669 chr6:146136114 FBXO30 -0.81 -11.61 -0.58 1.87e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.87 -13.78 -0.65 6.09e-33 Menarche (age at onset); CESC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg05863683 chr7:1912471 MAD1L1 0.47 7.08 0.4 1.28e-11 Bipolar disorder and schizophrenia; CESC cis rs4589502 1.000 rs16950284 chr15:67154184 A/G cg09911534 chr15:67153556 NA 0.53 5.63 0.33 4.55e-8 Lung cancer (smoking interaction); CESC cis rs950776 0.616 rs12901300 chr15:78892952 G/A cg24631222 chr15:78858424 CHRNA5 -0.43 -5.43 -0.32 1.3e-7 Sudden cardiac arrest; CESC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg26335602 chr6:28129616 ZNF389 0.44 5.61 0.33 5.19e-8 Parkinson's disease; CESC cis rs2479724 0.755 rs4318867 chr6:41753670 G/T cg17623882 chr6:41773611 USP49 0.41 5.64 0.33 4.29e-8 Menarche (age at onset); CESC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg05483915 chr17:80145575 CCDC57 0.45 5.49 0.32 9.41e-8 Breast cancer; CESC cis rs6088580 0.634 rs7271970 chr20:32987666 A/G cg24642439 chr20:33292090 TP53INP2 -0.52 -6.94 -0.39 3.04e-11 Glomerular filtration rate (creatinine); CESC cis rs4819052 0.788 rs9978857 chr21:46705155 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.62 7.98 0.44 4.47e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2882667 1.000 rs2882667 chr5:138314106 C/T cg04439458 chr5:138467593 SIL1 -0.35 -5.54 -0.32 7.22e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9911578 1.000 rs6503866 chr17:56619581 C/T cg12560992 chr17:57184187 TRIM37 -0.93 -15.59 -0.69 2.43e-39 Intelligence (multi-trait analysis); CESC cis rs10883723 0.810 rs7072351 chr10:104265047 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.25 0.41 4.46e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs8141529 0.748 rs6519766 chr22:29269991 A/G cg02153584 chr22:29168773 CCDC117 -0.56 -7.58 -0.42 5.98e-13 Lymphocyte counts; CESC cis rs1062177 1.000 rs6890099 chr5:151151962 A/G cg12924095 chr5:151150029 G3BP1 0.48 6.07 0.35 4.45e-9 Preschool internalizing problems; CESC cis rs12476592 0.602 rs959195 chr2:63804125 G/A cg17519650 chr2:63277830 OTX1 -0.48 -5.42 -0.32 1.34e-7 Childhood ear infection; CESC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.02 0.8 8.6e-62 Prudent dietary pattern; CESC cis rs2120019 0.935 rs34835684 chr15:75331805 T/G cg17294928 chr15:75287854 SCAMP5 -0.74 -8.31 -0.45 5.03e-15 Blood trace element (Zn levels); CESC cis rs6088590 0.965 rs6088620 chr20:33412022 A/G cg08999081 chr20:33150536 PIGU 0.58 8.9 0.48 9.24e-17 Coronary artery disease; CESC cis rs4909189 0.915 rs11773551 chr7:158136146 C/T cg25566285 chr7:158114605 PTPRN2 0.44 5.48 0.32 9.93e-8 Response to amphetamines; CESC cis rs9430161 0.579 rs6696575 chr1:11037136 G/A cg27631724 chr1:11040367 C1orf127 0.46 7.81 0.43 1.36e-13 Ewing sarcoma; CESC trans rs802075 0.905 rs1025348 chr6:49652760 T/C cg06254729 chr2:28550422 BRE -0.37 -6.14 -0.35 3e-9 Bone mineral density (hip) and age at menarche; CESC cis rs17376456 1.000 rs67150649 chr5:93292377 A/G cg21475434 chr5:93447410 FAM172A 0.72 6.08 0.35 4.11e-9 Diabetic retinopathy; CESC cis rs1878931 0.582 rs27239 chr16:3442140 T/C cg02880119 chr16:3481970 NA 0.42 5.31 0.31 2.35e-7 Body mass index (adult); CESC cis rs5167 0.504 rs3760625 chr19:45456941 G/A cg09555818 chr19:45449301 APOC2 0.41 6.54 0.37 3.08e-10 Blood protein levels; CESC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs1577917 0.876 rs12201992 chr6:86618219 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -5.75 -0.33 2.51e-8 Response to antipsychotic treatment; CESC cis rs8031584 1.000 rs35239376 chr15:31290538 A/C cg08704250 chr15:31115839 NA -0.65 -7.85 -0.43 1.05e-13 Huntington's disease progression; CESC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg24531977 chr5:56204891 C5orf35 -0.88 -11.51 -0.58 3.94e-25 Initial pursuit acceleration; CESC cis rs3008870 0.920 rs975452 chr1:67480190 A/T cg08660285 chr1:67390436 MIER1;WDR78 1.01 13.78 0.65 5.96e-33 Lymphocyte percentage of white cells; CESC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6073597 1.000 rs6031980 chr20:43714384 C/T cg23740882 chr20:44098387 WFDC2 0.33 5.04 0.3 8.45e-7 Positive affect; CESC cis rs2304069 0.545 rs9686746 chr5:149399968 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.46 6.17 0.35 2.51e-9 HIV-1 control; CESC cis rs7927592 0.546 rs638076 chr11:68202580 A/G cg01657329 chr11:68192670 LRP5 -0.55 -7.23 -0.41 5.33e-12 Total body bone mineral density; CESC cis rs9300255 0.568 rs1047158 chr12:123644056 C/A cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.16e-16 Neutrophil percentage of white cells; CESC cis rs8014204 0.839 rs6574197 chr14:75331487 A/G cg08847533 chr14:75593920 NEK9 -0.47 -5.82 -0.34 1.72e-8 Caffeine consumption; CESC cis rs4704187 0.687 rs7700965 chr5:74356857 T/C cg03227963 chr5:74354835 NA 0.29 5.32 0.31 2.22e-7 Response to amphetamines; CESC cis rs4604732 0.588 rs6677477 chr1:247629411 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.52 6.38 0.36 7.89e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs796364 0.616 rs2689762 chr2:200687204 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.56 5.08 0.3 7.26e-7 Schizophrenia; CESC cis rs2243480 1.000 rs34529418 chr7:65403209 A/G cg12463550 chr7:65579703 CRCP 0.7 5.7 0.33 3.21e-8 Diabetic kidney disease; CESC trans rs4950322 0.580 rs4950308 chr1:146591674 C/T cg04954894 chr8:38089920 DDHD2 -0.59 -6.45 -0.37 5.34e-10 Protein quantitative trait loci; CESC cis rs1355223 0.902 rs11603774 chr11:34732891 G/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.43 -0.37 5.87e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.26 0.36 1.51e-9 Cystic fibrosis severity; CESC cis rs614226 1.000 rs563920 chr12:121017439 A/G cg01236616 chr12:121019343 POP5 1.5 18.36 0.75 3.79e-49 Type 1 diabetes nephropathy; CESC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg19346786 chr7:2764209 NA -0.52 -7.38 -0.41 1.99e-12 Height; CESC cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg11366901 chr6:160182831 ACAT2 0.81 9.81 0.52 1.35e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs1577917 0.771 rs2842612 chr6:86303091 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -7.8 -0.43 1.46e-13 Response to antipsychotic treatment; CESC cis rs7107770 0.739 rs12793744 chr11:125079871 G/T cg27629782 chr11:125073726 PKNOX2 0.34 5.32 0.31 2.2e-7 Photic sneeze reflex; CESC cis rs7208859 0.673 rs73263776 chr17:29211331 G/C cg19761014 chr17:28927070 LRRC37B2 0.73 5.75 0.33 2.39e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg06074448 chr4:187884817 NA -0.37 -5.4 -0.31 1.5e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.954 rs12507964 chr4:120413061 T/A cg09307838 chr4:120376055 NA 0.92 12.96 0.62 4.27e-30 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26258877 chr1:155145555 TRIM46;KRTCAP2 0.61 6.74 0.38 9.85e-11 Gut microbiome composition (summer); CESC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg09699651 chr6:150184138 LRP11 0.4 5.11 0.3 6.05e-7 Lung cancer; CESC cis rs9905704 0.681 rs4793949 chr17:56571950 C/T cg12560992 chr17:57184187 TRIM37 0.65 6.03 0.35 5.43e-9 Testicular germ cell tumor; CESC trans rs11039798 0.511 rs717896 chr11:48375335 G/T cg15704280 chr7:45808275 SEPT13 -0.69 -6.75 -0.38 9.32e-11 Axial length; CESC cis rs561341 1.000 rs15654 chr17:30326360 A/C cg19193384 chr17:30244184 NA -0.7 -6.58 -0.37 2.49e-10 Hip circumference adjusted for BMI; CESC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg11764359 chr7:65958608 NA -0.79 -11.68 -0.58 1.07e-25 Aortic root size; CESC cis rs3096299 0.900 rs2911258 chr16:89480760 A/G cg02187348 chr16:89574699 SPG7 0.61 8.39 0.46 2.88e-15 Multiple myeloma (IgH translocation); CESC cis rs2235642 0.928 rs1057610 chr16:1605537 T/C cg03771183 chr16:1608904 IFT140 0.42 6.13 0.35 3.23e-9 Coronary artery disease; CESC cis rs796364 0.951 rs72932280 chr2:200996851 G/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.65 -6.27 -0.36 1.49e-9 Schizophrenia; CESC cis rs6484504 0.512 rs2761594 chr11:31318244 A/G cg14844989 chr11:31128820 NA 0.4 5.49 0.32 9.59e-8 Red blood cell count; CESC cis rs10949834 0.824 rs2285026 chr7:73530404 C/T cg07137043 chr7:73588983 EIF4H -0.67 -5.8 -0.34 1.9e-8 Verbal memory performance (residualized delayed recall change); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17364743 chr2:118572626 DDX18 -0.47 -6.0 -0.35 6.44e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs17666538 0.642 rs7821983 chr8:643696 A/G cg02524346 chr8:600233 NA 0.83 6.98 0.39 2.37e-11 IgG glycosylation; CESC cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg25517755 chr10:38738941 LOC399744 -0.47 -6.19 -0.36 2.32e-9 Extrinsic epigenetic age acceleration; CESC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg14829155 chr15:31115871 NA -0.72 -10.5 -0.54 8.92e-22 Huntington's disease progression; CESC cis rs921968 0.643 rs524012 chr2:219433273 T/G cg02176678 chr2:219576539 TTLL4 0.41 7.13 0.4 9.62e-12 Mean corpuscular hemoglobin concentration; CESC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg26039829 chr8:22132926 PIWIL2 -0.4 -6.32 -0.36 1.13e-9 Hypertriglyceridemia; CESC cis rs9796 0.621 rs1659227 chr15:41472398 G/A cg18705301 chr15:41695430 NDUFAF1 0.44 6.46 0.37 4.99e-10 Menopause (age at onset); CESC cis rs56104184 0.723 rs73063522 chr19:49408358 C/G cg15549821 chr19:49342101 PLEKHA4 -0.53 -5.47 -0.32 1.06e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs1882538 0.503 rs13240997 chr7:133135373 C/A cg10665199 chr7:133106180 EXOC4 0.58 7.77 0.43 1.68e-13 Intelligence (multi-trait analysis); CESC cis rs710216 0.957 rs841570 chr1:43435571 C/G cg07803811 chr1:43423981 SLC2A1 0.47 5.07 0.3 7.58e-7 Red cell distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04310824 chr1:53393297 SCP2 -0.64 -7.4 -0.41 1.82e-12 Gut microbiome composition (summer); CESC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg16278512 chr7:12443529 VWDE -0.55 -5.87 -0.34 1.27e-8 Coronary artery disease; CESC cis rs1881797 0.932 rs2387038 chr1:247674919 G/A cg21399703 chr1:247681439 NA 0.61 7.74 0.43 2.03e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg26587870 chr6:27730563 NA -0.58 -5.21 -0.3 3.74e-7 Depression; CESC trans rs629535 0.734 rs542288 chr8:70057149 G/T cg21567404 chr3:27674614 NA -0.88 -10.51 -0.54 8.12e-22 Dupuytren's disease; CESC cis rs72781680 0.898 rs72782136 chr2:24047344 A/G cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs977987 0.843 rs11641801 chr16:75455448 A/C cg03315344 chr16:75512273 CHST6 0.41 5.9 0.34 1.08e-8 Dupuytren's disease; CESC cis rs1670533 1.000 rs13119276 chr4:1051574 T/C cg27284194 chr4:1044797 NA 0.45 5.54 0.32 7.32e-8 Recombination rate (females); CESC cis rs854765 0.927 rs4925138 chr17:17992793 T/G cg09796270 chr17:17721594 SREBF1 -0.39 -5.32 -0.31 2.26e-7 Total body bone mineral density; CESC cis rs11587400 0.634 rs7553926 chr1:115202215 A/G cg12756093 chr1:115239321 AMPD1 -0.42 -5.69 -0.33 3.28e-8 Autism; CESC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg04025307 chr7:1156635 C7orf50 0.53 9.42 0.5 2.27e-18 Longevity;Endometriosis; CESC cis rs2735413 0.794 rs55951868 chr16:78078804 C/A cg04733911 chr16:78082701 NA -0.52 -8.37 -0.46 3.34e-15 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg09509183 chr1:209979624 IRF6 -0.49 -5.33 -0.31 2.15e-7 Cleft lip with or without cleft palate; CESC cis rs116095464 0.558 rs6866776 chr5:264495 C/T cg22857025 chr5:266934 NA -1.3 -18.55 -0.75 8.05e-50 Breast cancer; CESC cis rs9611565 0.918 rs7290404 chr22:41749796 C/T cg17376030 chr22:41985996 PMM1 0.65 6.96 0.39 2.61e-11 Vitiligo; CESC cis rs4711336 1.000 rs2296738 chr6:33656850 C/T cg14003231 chr6:33640908 ITPR3 0.34 5.74 0.33 2.57e-8 Height; CESC cis rs1538970 1.000 rs11211101 chr1:45849311 C/G cg06784218 chr1:46089804 CCDC17 0.32 5.53 0.32 7.51e-8 Platelet count; CESC cis rs1642645 1.000 rs1642645 chr1:42502281 A/C cg16685388 chr1:42384056 HIVEP3 0.37 5.04 0.3 8.67e-7 Left ventricular obstructive tract defect (maternal effect); CESC cis rs854765 0.663 rs3744115 chr17:17749822 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.5 -6.98 -0.39 2.36e-11 Total body bone mineral density; CESC cis rs4660306 0.961 rs4660868 chr1:45986497 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.72 -0.43 2.33e-13 Homocysteine levels; CESC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs6060717 0.536 rs17431878 chr20:34502107 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.7 0.33 3.16e-8 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg05373962 chr22:49881684 NA -0.37 -6.38 -0.36 7.92e-10 Monocyte count;Monocyte percentage of white cells; CESC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg05564831 chr3:52568323 NT5DC2 0.47 7.32 0.41 2.96e-12 Electroencephalogram traits; CESC cis rs113835537 0.529 rs11550299 chr11:66254085 G/T cg24851651 chr11:66362959 CCS 0.45 5.62 0.33 4.87e-8 Airway imaging phenotypes; CESC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg01341218 chr17:43662625 NA -0.52 -6.74 -0.38 9.77e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs3857536 0.544 rs208453 chr6:66906841 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.62 -7.27 -0.41 4.04e-12 Blood trace element (Cu levels); CESC cis rs7923609 0.838 rs7909960 chr10:65239177 T/A cg01631684 chr10:65280961 REEP3 -0.44 -5.44 -0.32 1.2e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg13733410 chr7:12443478 VWDE -0.48 -5.08 -0.3 7.14e-7 Coronary artery disease; CESC trans rs10242455 0.702 rs45461000 chr7:99052710 A/G cg09045935 chr12:6379348 NA 0.9 7.41 0.41 1.68e-12 Blood metabolite levels; CESC cis rs1065852 0.526 rs9623489 chr22:42397026 A/G cg22189786 chr22:42395067 WBP2NL 0.43 5.4 0.31 1.46e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs17209837 0.607 rs1473152 chr7:87080350 A/C cg00919237 chr7:87102261 ABCB4 -0.51 -6.61 -0.38 2.1e-10 Gallbladder cancer; CESC cis rs10504229 0.516 rs4060631 chr8:57990757 G/A cg24829409 chr8:58192753 C8orf71 -0.36 -5.11 -0.3 6.21e-7 Developmental language disorder (linguistic errors); CESC cis rs1707322 0.721 rs4559551 chr1:46167533 T/C cg05343316 chr1:45956843 TESK2 0.5 6.08 0.35 4.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11264213 0.786 rs72659684 chr1:36274624 C/T cg27506609 chr1:36549197 TEKT2 0.65 5.34 0.31 1.97e-7 Schizophrenia; CESC cis rs3806843 0.966 rs2563264 chr5:140137503 T/G cg26395211 chr5:140044315 WDR55 0.39 5.17 0.3 4.51e-7 Depressive symptoms (multi-trait analysis); CESC trans rs1908814 0.516 rs13252854 chr8:11792978 T/A cg15556689 chr8:8085844 FLJ10661 0.54 6.58 0.37 2.47e-10 Neuroticism; CESC cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg21573476 chr21:45109991 RRP1B -0.51 -7.1 -0.4 1.13e-11 Mean corpuscular volume; CESC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg02776659 chr21:47717406 C21orf57 -0.38 -5.19 -0.3 4.16e-7 Testicular germ cell tumor; CESC cis rs2302190 0.882 rs7209650 chr17:56674905 C/T cg25885038 chr17:56607967 SEPT4 -0.4 -5.41 -0.32 1.42e-7 Vitamin D levels; CESC cis rs2262909 0.962 rs55728714 chr19:22262899 A/G cg11619707 chr19:22235551 ZNF257 0.34 5.37 0.31 1.71e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg25036284 chr2:26402008 FAM59B -0.71 -8.57 -0.47 8.47e-16 Gut microbiome composition (summer); CESC cis rs791888 0.929 rs2755431 chr10:89415104 C/T cg13926569 chr10:89418898 PAPSS2 -0.45 -6.46 -0.37 4.92e-10 Magnesium levels; CESC cis rs7267979 1.000 rs34645895 chr20:25368373 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.23e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg27266027 chr21:40555129 PSMG1 0.45 5.34 0.31 2e-7 Cognitive function; CESC cis rs4727027 0.801 rs12666337 chr7:148796253 C/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.8 -0.39 6.72e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22542702 chr2:132384461 NA 0.36 6.03 0.35 5.49e-9 Fibrinogen levels; CESC cis rs1163251 0.837 rs611365 chr1:120242571 C/T cg19096424 chr1:120255104 PHGDH 0.52 6.67 0.38 1.52e-10 Blood metabolite levels; CESC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg19592336 chr6:28129416 ZNF389 0.54 7.45 0.42 1.31e-12 Parkinson's disease; CESC cis rs6430585 0.583 rs12475516 chr2:136560761 C/G cg07169764 chr2:136633963 MCM6 1.2 16.6 0.71 6.77e-43 Corneal structure; CESC cis rs2635047 0.682 rs1980055 chr18:44792636 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.09 0.3 6.89e-7 Educational attainment; CESC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg11764359 chr7:65958608 NA -0.69 -8.8 -0.48 1.76e-16 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08494708 chr6:108881870 FOXO3 -0.46 -6.54 -0.37 3.21e-10 Fibrinogen levels; CESC cis rs921968 0.565 rs62191658 chr2:219630294 A/G cg02176678 chr2:219576539 TTLL4 -0.43 -7.64 -0.42 4.07e-13 Mean corpuscular hemoglobin concentration; CESC cis rs11214589 0.905 rs12805699 chr11:113241810 T/A cg14159747 chr11:113255604 NA 0.32 5.6 0.33 5.38e-8 Neuroticism; CESC cis rs965469 0.779 rs6139092 chr20:3334651 T/C cg25506879 chr20:3388711 C20orf194 -0.48 -5.15 -0.3 5.18e-7 IFN-related cytopenia; CESC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg21285383 chr16:89894308 SPIRE2 0.31 5.54 0.32 7.34e-8 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13679776 chr1:64936373 CACHD1 0.53 6.24 0.36 1.76e-9 Gut microbiome composition (summer); CESC cis rs950776 0.518 rs11636131 chr15:78821606 C/T cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg11812906 chr14:75593930 NEK9 -0.9 -14.82 -0.67 1.35e-36 Height; CESC cis rs3820928 0.647 rs2115597 chr2:227791218 T/C cg05526886 chr2:227700861 RHBDD1 -0.55 -7.61 -0.42 4.67e-13 Pulmonary function; CESC trans rs1814175 0.645 rs6486022 chr11:49776137 A/G cg11707556 chr5:10655725 ANKRD33B -0.42 -6.06 -0.35 4.69e-9 Height; CESC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg15145296 chr3:125709740 NA -0.56 -5.91 -0.34 1.06e-8 Blood pressure (smoking interaction); CESC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg13607699 chr17:42295918 UBTF 0.61 8.15 0.45 1.44e-14 Total body bone mineral density; CESC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg09658497 chr7:2847517 GNA12 -0.36 -5.07 -0.3 7.62e-7 Height; CESC cis rs763121 0.524 rs760645 chr22:39032270 C/T cg06544989 chr22:39130855 UNC84B 0.34 5.36 0.31 1.78e-7 Menopause (age at onset); CESC cis rs2882667 0.858 rs13177503 chr5:138432759 G/C cg04439458 chr5:138467593 SIL1 -0.4 -6.21 -0.36 2.04e-9 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15188491 chr1:146644106 PRKAB2 0.51 6.66 0.38 1.61e-10 Systemic lupus erythematosus; CESC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.22 0.31 3.53e-7 Bipolar disorder; CESC cis rs6088590 1.000 rs6088607 chr20:33378733 C/T cg06115741 chr20:33292138 TP53INP2 0.59 7.31 0.41 3.17e-12 Coronary artery disease; CESC cis rs7208859 0.623 rs216446 chr17:28933718 T/G cg14008862 chr17:28927542 LRRC37B2 0.73 5.52 0.32 8.23e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.15 -0.53 1.2e-20 Alzheimer's disease; CESC cis rs5769765 0.779 rs12170530 chr22:50318422 T/G cg02269571 chr22:50332266 NA -0.55 -6.42 -0.37 6.1e-10 Schizophrenia; CESC cis rs10870270 1.000 rs7199 chr10:133769848 C/G cg17892150 chr10:133769511 PPP2R2D -0.86 -12.56 -0.61 1.08e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs11992162 0.636 rs4841642 chr8:11798334 C/T cg15556689 chr8:8085844 FLJ10661 0.52 6.46 0.37 4.98e-10 Monocyte count; CESC cis rs7772486 0.875 rs2777481 chr6:146310036 G/T cg23711669 chr6:146136114 FBXO30 0.84 11.88 0.59 2.26e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 9.98 0.52 4.19e-20 Prudent dietary pattern; CESC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg17221315 chr6:27791827 HIST1H4J 0.45 5.81 0.34 1.75e-8 Cardiac Troponin-T levels; CESC cis rs7264396 0.676 rs6060727 chr20:34556000 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.29 -0.53 4.22e-21 Total cholesterol levels; CESC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg07701084 chr6:150067640 NUP43 0.4 5.48 0.32 9.87e-8 Lung cancer; CESC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg24675658 chr1:53192096 ZYG11B -0.59 -7.66 -0.43 3.46e-13 Monocyte count; CESC cis rs709400 0.628 rs7146506 chr14:103924477 A/G cg12935359 chr14:103987150 CKB -0.51 -7.46 -0.42 1.21e-12 Body mass index; CESC trans rs9325144 0.577 rs10876008 chr12:39126750 T/C cg23762105 chr12:34175262 ALG10 0.46 6.01 0.35 5.98e-9 Morning vs. evening chronotype; CESC trans rs4596713 0.538 rs1416738 chr9:71787927 C/T cg16512924 chr15:28394682 HERC2 0.48 6.09 0.35 4.06e-9 Headache; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05227655 chr10:26986590 PDSS1 0.52 6.11 0.35 3.5e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17517865 chr1:112532085 KCND3 0.56 6.29 0.36 1.31e-9 Gut microbiome composition (summer); CESC cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg26769984 chr7:1090371 C7orf50 0.65 7.13 0.4 9.52e-12 Bronchopulmonary dysplasia; CESC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.86 8.85 0.48 1.24e-16 Platelet count; CESC cis rs13253111 0.687 rs7840565 chr8:28060783 C/T cg26534493 chr8:28060551 NA 0.52 8.71 0.47 3.25e-16 Childhood body mass index; CESC cis rs9291683 0.595 rs11731110 chr4:10037346 T/C cg00071950 chr4:10020882 SLC2A9 0.87 15.5 0.69 5.26e-39 Bone mineral density; CESC cis rs1707322 0.656 rs9429172 chr1:46092476 C/G cg06784218 chr1:46089804 CCDC17 -0.4 -7.01 -0.4 1.97e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9354308 0.868 rs9363465 chr6:66557802 A/C cg07460842 chr6:66804631 NA -0.43 -5.19 -0.3 4.26e-7 Metabolite levels; CESC cis rs6831352 0.842 rs1230156 chr4:99989626 C/T cg13256891 chr4:100009986 ADH5 0.77 8.86 0.48 1.16e-16 Alcohol dependence; CESC cis rs10189230 0.967 rs12993766 chr2:222350321 C/T cg14652038 chr2:222343519 EPHA4 0.36 7.56 0.42 6.58e-13 Urate levels in lean individuals; CESC cis rs1568889 1.000 rs1464897 chr11:28034844 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.02 0.56 1.73e-23 Bipolar disorder; CESC cis rs977987 0.836 rs7199062 chr16:75474827 G/A cg03315344 chr16:75512273 CHST6 0.43 6.2 0.36 2.11e-9 Dupuytren's disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12738264 chr7:148725795 PDIA4 0.46 6.89 0.39 4.04e-11 Systemic lupus erythematosus; CESC cis rs9891119 0.663 rs2883456 chr17:40552794 A/G cg21433558 chr17:40837037 CNTNAP1 0.4 5.28 0.31 2.73e-7 Multiple sclerosis;Crohn's disease; CESC cis rs10751667 0.600 rs10794342 chr11:924904 C/T cg06064525 chr11:970664 AP2A2 -0.51 -10.06 -0.53 2.19e-20 Alzheimer's disease (late onset); CESC cis rs7100689 0.646 rs1890889 chr10:82090827 G/T cg00277334 chr10:82204260 NA -0.61 -8.25 -0.45 7.58e-15 Post bronchodilator FEV1; CESC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg00310523 chr12:86230176 RASSF9 0.35 5.49 0.32 9.42e-8 Major depressive disorder; CESC cis rs72945132 0.882 rs7929271 chr11:70165749 A/G cg00319359 chr11:70116639 PPFIA1 0.78 7.75 0.43 1.98e-13 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23634566 chr6:42531994 UBR2 0.66 7.51 0.42 9.01e-13 Gut microbiome composition (summer); CESC trans rs561341 0.505 rs28708703 chr17:30386845 C/G cg27661571 chr11:113659931 NA -0.67 -6.73 -0.38 1.02e-10 Hip circumference adjusted for BMI; CESC cis rs67311347 1.000 rs4246666 chr3:40407670 C/T cg09455208 chr3:40491958 NA 0.45 7.78 0.43 1.64e-13 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11609545 chr12:57024192 BAZ2A 0.6 6.82 0.39 6.03e-11 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs4718315 chr7:65648541 T/C cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.24e-32 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05817661 chr11:93517837 MED17 0.57 6.35 0.36 9.23e-10 Gut microbiome composition (summer); CESC cis rs6426558 0.537 rs2670462 chr1:227432923 C/G cg10327440 chr1:227177885 CDC42BPA -0.48 -5.82 -0.34 1.66e-8 Neutrophil percentage of white cells; CESC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.62 -0.33 4.74e-8 Total body bone mineral density; CESC cis rs2997447 0.723 rs56241003 chr1:26435919 C/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg04772025 chr11:68637568 NA 0.5 5.83 0.34 1.63e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20435464 chr19:40711928 MAP3K10 -0.52 -6.01 -0.35 6.05e-9 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg22920501 chr2:26401640 FAM59B -0.65 -7.73 -0.43 2.27e-13 Gut microbiome composition (summer); CESC cis rs6964587 0.869 rs401 chr7:91527945 T/G cg17063962 chr7:91808500 NA -0.53 -7.0 -0.39 2.11e-11 Breast cancer; CESC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.97 0.48 5.62e-17 Bipolar disorder; CESC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg13114125 chr14:105738426 BRF1 -0.89 -11.05 -0.56 1.31e-23 Mean platelet volume;Platelet distribution width; CESC cis rs6594713 0.756 rs6872490 chr5:112784592 T/C cg12552261 chr5:112820674 MCC 0.6 6.47 0.37 4.67e-10 Brain cytoarchitecture; CESC cis rs1322639 0.531 rs11751421 chr6:169574993 T/C cg04662567 chr6:169592167 NA 0.41 5.99 0.35 6.69e-9 Pulse pressure; CESC cis rs2354432 0.607 rs12404113 chr1:146750343 C/A cg25205988 chr1:146714368 CHD1L -0.94 -8.35 -0.46 3.88e-15 Mitochondrial DNA levels; CESC cis rs11112613 0.775 rs61200462 chr12:105969271 G/A cg03607813 chr12:105948248 NA 0.56 6.26 0.36 1.58e-9 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC trans rs6931865 0.508 rs9321941 chr6:144064904 A/G cg02864954 chr6:154535553 IPCEF1;OPRM1 -0.39 -6.51 -0.37 3.77e-10 Erectile dysfunction in type 1 diabetes; CESC cis rs7927771 0.931 rs12361256 chr11:47910823 A/C cg05585544 chr11:47624801 NA -0.42 -6.9 -0.39 3.85e-11 Subjective well-being; CESC cis rs1008375 0.966 rs2315645 chr4:17579678 G/C cg16339924 chr4:17578868 LAP3 0.75 9.84 0.52 1.12e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18861140 chr18:3449789 TGIF1 0.6 7.37 0.41 2.2e-12 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs10143002 chr14:56074278 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.96 -0.39 2.75e-11 Putamen volume; CESC cis rs4523957 0.583 rs2641442 chr17:2035071 C/T cg16513277 chr17:2031491 SMG6 -0.78 -11.57 -0.58 2.42e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs131777 0.708 rs131749 chr22:51024624 C/T cg25309564 chr22:51001381 C22orf41 -0.61 -7.81 -0.43 1.31e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs12711979 0.509 rs1031478 chr2:3827425 G/A cg17052675 chr2:3827356 NA -0.67 -11.25 -0.57 2.84e-24 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs4853012 0.887 rs2280644 chr2:74358411 G/A cg19729930 chr2:74357872 NA 0.87 12.57 0.61 1e-28 Gestational age at birth (maternal effect); CESC cis rs4253772 0.872 rs45528736 chr22:46638312 A/G cg00784671 chr22:46762841 CELSR1 -0.51 -5.27 -0.31 2.87e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7726839 0.507 rs60068988 chr5:597668 T/C cg16447950 chr5:562315 NA -0.59 -6.01 -0.35 6.18e-9 Obesity-related traits; CESC cis rs4076764 0.957 rs4443867 chr1:163434917 T/C cg06092702 chr1:163392909 NA -0.37 -5.38 -0.31 1.67e-7 Motion sickness; CESC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.42 0.32 1.34e-7 Major depressive disorder; CESC cis rs3105593 1.000 rs3848130 chr15:50892111 A/G cg08437265 chr15:50716283 USP8 0.41 5.19 0.3 4.1e-7 QT interval; CESC cis rs7246657 0.943 rs10417503 chr19:37842735 T/C cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.07 0.4 1.39e-11 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07985315 chr22:39240100 NPTXR 0.58 6.55 0.37 2.98e-10 Gut microbiome composition (summer); CESC cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg10523679 chr1:76189770 ACADM -0.66 -6.71 -0.38 1.15e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg18404041 chr3:52824283 ITIH1 -0.37 -5.99 -0.35 6.83e-9 Bipolar disorder; CESC cis rs9611565 0.649 rs139553 chr22:42187199 A/G cg03806693 chr22:41940476 POLR3H 0.78 9.47 0.5 1.61e-18 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23888281 chr1:45476762 HECTD3;UROD 0.53 6.18 0.35 2.4e-9 Gut microbiome composition (summer); CESC cis rs3862030 0.839 rs2281880 chr10:104269217 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.37 -5.22 -0.31 3.54e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs2011503 1.000 rs11670882 chr19:19649748 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.03 0.3 8.99e-7 Bipolar disorder; CESC cis rs11122272 0.735 rs2749709 chr1:231530476 G/T cg06096015 chr1:231504339 EGLN1 0.42 6.08 0.35 4.21e-9 Hemoglobin concentration; CESC cis rs6598955 0.724 rs869683 chr1:26570993 T/A cg19743891 chr1:26644573 UBXN11;CD52 -0.27 -5.3 -0.31 2.43e-7 Obesity-related traits; CESC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg22903471 chr2:27725779 GCKR -0.52 -7.48 -0.42 1.07e-12 Total body bone mineral density; CESC cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg06212747 chr3:49208901 KLHDC8B 0.66 8.74 0.47 2.71e-16 Parkinson's disease; CESC cis rs3733585 0.699 rs4408959 chr4:9948868 C/T cg02734326 chr4:10020555 SLC2A9 -0.41 -5.76 -0.33 2.38e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.44 5.37 0.31 1.7e-7 Tonsillectomy; CESC cis rs8060686 0.764 rs73599521 chr16:67733322 G/A cg26727032 chr16:67993705 SLC12A4 -0.57 -6.0 -0.35 6.41e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs1624802 0.967 rs1696432 chr12:130496976 A/G cg15444478 chr12:130494697 NA -0.26 -5.19 -0.3 4.09e-7 Obesity-related traits; CESC cis rs4919687 0.550 rs12780827 chr10:104467954 T/C cg04362960 chr10:104952993 NT5C2 0.47 5.34 0.31 1.99e-7 Colorectal cancer; CESC cis rs6570726 0.935 rs374000 chr6:145855290 C/T cg23711669 chr6:146136114 FBXO30 0.8 11.75 0.59 6.33e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs6570726 0.902 rs373321 chr6:145854150 T/A cg23711669 chr6:146136114 FBXO30 0.8 11.74 0.58 6.58e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs6493487 0.505 rs8034918 chr15:51095431 A/G cg02338191 chr15:51200825 AP4E1 -0.53 -5.09 -0.3 6.92e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7809950 0.817 rs11535285 chr7:107143866 A/G cg23024343 chr7:107201750 COG5 -0.55 -7.23 -0.41 5.06e-12 Coronary artery disease; CESC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg22823121 chr1:150693482 HORMAD1 -0.4 -5.44 -0.32 1.21e-7 Blood protein levels; CESC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.51 6.04 0.35 5.07e-9 Breast cancer; CESC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg09263875 chr16:632152 PIGQ 0.68 11.71 0.58 8.57e-26 Height; CESC cis rs2710642 0.564 rs60144282 chr2:62843163 G/T cg17519650 chr2:63277830 OTX1 0.48 6.44 0.37 5.71e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs7178572 0.524 rs1473922 chr15:77656798 G/T cg22256960 chr15:77711686 NA -0.53 -6.79 -0.38 7.53e-11 Type 2 diabetes; CESC cis rs7714584 1.000 rs59980321 chr5:150241813 A/T cg22134413 chr5:150180641 NA 0.53 5.82 0.34 1.69e-8 Crohn's disease; CESC cis rs920590 0.721 rs920587 chr8:19663339 C/A cg17834443 chr8:19674713 INTS10 0.58 6.62 0.38 1.95e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs6866344 0.697 rs61247551 chr5:178133503 G/A cg03877680 chr5:178157825 ZNF354A 0.76 8.58 0.47 8.33e-16 Neutrophil percentage of white cells; CESC cis rs3809863 0.782 rs7220606 chr17:45374795 A/G cg08085267 chr17:45401833 C17orf57 -0.62 -8.44 -0.46 2.12e-15 Glaucoma (primary open-angle); CESC cis rs4689388 0.750 rs12642481 chr4:6301058 G/A cg25554036 chr4:6271136 WFS1 0.48 7.07 0.4 1.34e-11 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05922392 chr5:180650178 TRIM41 0.58 6.56 0.37 2.76e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7582720 1.000 rs72936856 chr2:203775712 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs735396 0.627 rs2264778 chr12:121450354 C/A cg25281562 chr12:121454272 C12orf43 0.53 6.79 0.39 7.19e-11 N-glycan levels; CESC cis rs4906332 1.000 rs17680085 chr14:103953154 T/C cg09975044 chr14:104007538 NA 0.47 6.36 0.36 8.93e-10 Coronary artery disease; CESC cis rs637571 0.584 rs659824 chr11:65636509 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.68 -8.61 -0.47 6.54e-16 Eosinophil percentage of white cells; CESC cis rs9399135 0.967 rs6919862 chr6:135352443 C/A cg24558204 chr6:135376177 HBS1L 0.52 7.14 0.4 8.72e-12 Red blood cell count; CESC cis rs7584330 0.910 rs66509917 chr2:238395394 T/G cg14458575 chr2:238380390 NA 0.6 8.44 0.46 2.12e-15 Prostate cancer; CESC cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg17775713 chr3:133465469 TF 0.35 6.26 0.36 1.52e-9 Iron status biomarkers (transferrin levels); CESC cis rs11098499 1.000 rs28419773 chr4:120211061 T/C cg09307838 chr4:120376055 NA 0.88 11.91 0.59 1.75e-26 Corneal astigmatism; CESC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg23281280 chr6:28129359 ZNF389 -0.5 -7.03 -0.4 1.73e-11 Depression; CESC cis rs6690583 0.623 rs111687161 chr1:85443533 A/G cg22153463 chr1:85462885 MCOLN2 0.74 7.19 0.4 6.49e-12 Serum sulfate level; CESC cis rs2576037 0.583 rs680018 chr18:44409167 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.14 -0.4 9.07e-12 Personality dimensions; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07300030 chr2:165698022 COBLL1 -0.48 -6.8 -0.39 7.1e-11 Gut microbiota (bacterial taxa); CESC cis rs3733585 0.699 rs7435196 chr4:9967556 A/C cg02734326 chr4:10020555 SLC2A9 -0.4 -5.68 -0.33 3.62e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9399135 0.527 rs61738492 chr6:135282771 G/A cg22676075 chr6:135203613 NA 0.51 6.61 0.38 2.1e-10 Red blood cell count; CESC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg01017244 chr2:74357527 NA 0.58 7.58 0.42 5.95e-13 Gestational age at birth (maternal effect); CESC cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.49 -6.29 -0.36 1.3e-9 Total body bone mineral density; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg13932035 chr19:11266624 SPC24 0.49 6.34 0.36 9.98e-10 Attention deficit hyperactivity disorder; CESC cis rs1059312 1.000 rs3825180 chr12:129279242 A/G cg09035930 chr12:129282057 SLC15A4 -0.78 -10.89 -0.56 4.58e-23 Systemic lupus erythematosus; CESC cis rs728616 0.867 rs76239460 chr10:81723227 C/T cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg17340268 chr14:105411764 AHNAK2 -0.51 -6.88 -0.39 4.35e-11 Rheumatoid arthritis; CESC cis rs9858542 0.953 rs34588335 chr3:49407660 G/C cg03060546 chr3:49711283 APEH -0.54 -6.1 -0.35 3.73e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg06481639 chr22:41940642 POLR3H 0.57 6.3 0.36 1.25e-9 Vitiligo; CESC cis rs9362426 1.000 rs9362426 chr6:88089874 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.45 5.52 0.32 8.26e-8 Depressive episodes in bipolar disorder; CESC cis rs721399 0.542 rs10085931 chr8:18245449 A/G cg18736775 chr8:18248649 NAT2 -0.49 -5.42 -0.32 1.37e-7 Blood metabolite levels; CESC cis rs7084402 0.967 rs1427197 chr10:60275150 A/G cg07615347 chr10:60278583 BICC1 -0.57 -8.96 -0.48 6.01e-17 Refractive error; CESC cis rs3820068 0.603 rs7537618 chr1:15977682 G/A cg16988262 chr1:15930761 NA 0.33 5.36 0.31 1.81e-7 Systolic blood pressure; CESC cis rs4595586 0.545 rs3914595 chr12:39388530 G/T cg26384229 chr12:38710491 ALG10B 0.54 7.58 0.42 5.91e-13 Morning vs. evening chronotype; CESC cis rs73206853 0.563 rs57488849 chr12:111181785 C/T cg12870014 chr12:110450643 ANKRD13A 0.73 5.41 0.32 1.39e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs9325144 0.560 rs7980635 chr12:38668355 G/T cg23762105 chr12:34175262 ALG10 0.48 6.29 0.36 1.32e-9 Morning vs. evening chronotype; CESC cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg12292205 chr6:26970375 C6orf41 -0.53 -5.76 -0.33 2.33e-8 Intelligence (multi-trait analysis); CESC cis rs4835473 0.932 rs34653324 chr4:144656211 A/G cg25736465 chr4:144833511 NA -0.33 -5.3 -0.31 2.48e-7 Immature fraction of reticulocytes; CESC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.3 -5.39 -0.31 1.53e-7 Electroencephalogram traits; CESC cis rs7809950 0.817 rs2712224 chr7:107181235 C/A cg23024343 chr7:107201750 COG5 -0.57 -7.22 -0.41 5.44e-12 Coronary artery disease; CESC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg18252515 chr7:66147081 NA 0.47 6.18 0.36 2.35e-9 Aortic root size; CESC cis rs7827545 1.000 rs9644456 chr8:135568656 G/T cg17885191 chr8:135476712 NA 0.47 6.18 0.36 2.34e-9 Hypertension (SNP x SNP interaction); CESC cis rs4242434 0.699 rs878051 chr8:22483836 T/C cg03733263 chr8:22462867 KIAA1967 0.75 11.22 0.57 3.69e-24 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs4595586 0.525 rs7313120 chr12:39388027 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.6 0.42 4.97e-13 Morning vs. evening chronotype; CESC cis rs6456156 0.811 rs975822 chr6:167516458 C/T cg07741184 chr6:167504864 NA -0.33 -5.54 -0.32 7.29e-8 Primary biliary cholangitis; CESC cis rs11249608 0.636 rs62393070 chr5:178447943 A/G cg01312482 chr5:178451176 ZNF879 -0.42 -5.67 -0.33 3.63e-8 Pubertal anthropometrics; CESC cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg14784868 chr12:69753453 YEATS4 0.73 10.66 0.55 2.59e-22 Blood protein levels; CESC cis rs3733585 0.699 rs4276278 chr4:9948870 T/C cg11266682 chr4:10021025 SLC2A9 -0.59 -11.14 -0.56 6.82e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3126085 0.935 rs10888470 chr1:152200472 T/C cg03465714 chr1:152285911 FLG -0.43 -5.24 -0.31 3.23e-7 Atopic dermatitis; CESC cis rs12586317 0.576 rs2415275 chr14:35668951 G/A cg16230307 chr14:35515116 FAM177A1 0.41 5.04 0.3 8.5e-7 Psoriasis; CESC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg26408565 chr15:76604113 ETFA -0.43 -6.25 -0.36 1.65e-9 Blood metabolite levels; CESC cis rs6540559 0.611 rs61747285 chr1:210004332 G/A cg25204440 chr1:209979598 IRF6 0.66 6.47 0.37 4.79e-10 Cleft lip with or without cleft palate; CESC cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg05585544 chr11:47624801 NA -0.49 -7.17 -0.4 7.45e-12 Subjective well-being; CESC cis rs12155623 0.578 rs13277226 chr8:49883029 G/T cg00325661 chr8:49890786 NA -0.38 -5.45 -0.32 1.16e-7 Sudden cardiac arrest; CESC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg07701084 chr6:150067640 NUP43 0.42 5.49 0.32 9.2e-8 Lung cancer; CESC cis rs9399135 0.967 rs1041480 chr6:135373076 G/T cg24558204 chr6:135376177 HBS1L 0.51 6.99 0.39 2.27e-11 Red blood cell count; CESC cis rs2274273 0.662 rs4040064 chr14:55678088 G/T cg04306507 chr14:55594613 LGALS3 0.31 5.26 0.31 3.03e-7 Protein biomarker; CESC cis rs36051895 0.659 rs12339666 chr9:5063296 A/C cg02405213 chr9:5042618 JAK2 0.47 5.89 0.34 1.14e-8 Pediatric autoimmune diseases; CESC cis rs1865721 0.917 rs62089506 chr18:73178913 A/G cg26385618 chr18:73139727 C18orf62 -0.52 -7.51 -0.42 8.78e-13 Intelligence; CESC cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg19723775 chr5:179050963 HNRNPH1 0.41 5.46 0.32 1.08e-7 Lung cancer; CESC cis rs11190604 1.000 rs11292 chr10:102313607 A/G cg07080220 chr10:102295463 HIF1AN 0.56 5.59 0.33 5.51e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs2294693 0.786 rs10456497 chr6:40989057 T/C cg14418226 chr6:40996092 UNC5CL 0.52 5.73 0.33 2.72e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs7246657 0.943 rs4801803 chr19:37966923 A/G cg23950597 chr19:37808831 NA 0.58 5.91 0.34 1.03e-8 Coronary artery calcification; CESC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg20573242 chr4:122745356 CCNA2 0.62 7.51 0.42 9.24e-13 Type 2 diabetes; CESC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg27266027 chr21:40555129 PSMG1 0.43 5.09 0.3 6.68e-7 Cognitive function; CESC cis rs854765 0.547 rs4365348 chr17:17912548 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.4 0.41 1.84e-12 Total body bone mineral density; CESC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg18446336 chr7:2847575 GNA12 -0.38 -5.8 -0.34 1.84e-8 Height; CESC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg18876405 chr7:65276391 NA -0.53 -6.89 -0.39 4.1e-11 Aortic root size; CESC cis rs2120019 1.000 rs34237279 chr15:75361121 A/G cg09165964 chr15:75287851 SCAMP5 -0.74 -8.85 -0.48 1.3e-16 Blood trace element (Zn levels); CESC cis rs67478160 0.643 rs1535098 chr14:104216513 T/A cg08213375 chr14:104286397 PPP1R13B 0.54 10.89 0.56 4.58e-23 Schizophrenia; CESC trans rs17685 0.775 rs11761172 chr7:75761547 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 12.41 0.61 3.51e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs7560272 0.538 rs2421575 chr2:73919522 G/A cg20560298 chr2:73613845 ALMS1 0.45 6.16 0.35 2.73e-9 Schizophrenia; CESC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg03609598 chr5:56110824 MAP3K1 -0.54 -5.69 -0.33 3.42e-8 Initial pursuit acceleration; CESC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg05025164 chr4:1340916 KIAA1530 0.5 6.79 0.38 7.46e-11 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22748686 chr17:42296315 UBTF 0.57 6.29 0.36 1.29e-9 Gut microbiome composition (summer); CESC trans rs1728785 1.000 rs821167 chr16:68577222 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.64 7.46 0.42 1.26e-12 Ulcerative colitis; CESC cis rs67478160 0.643 rs11847468 chr14:104220295 G/A cg08213375 chr14:104286397 PPP1R13B 0.55 11.17 0.57 5.38e-24 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26251429 chr2:28113398 BRE;RBKS;LOC100302650 0.63 7.84 0.43 1.07e-13 Gut microbiome composition (summer); CESC cis rs75804782 0.581 rs72987336 chr2:239365345 T/C cg18131467 chr2:239335373 ASB1 -0.7 -5.56 -0.32 6.42e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs4481887 0.790 rs4382760 chr1:248422343 A/C cg00666640 chr1:248458726 OR2T12 -0.35 -6.05 -0.35 4.89e-9 Common traits (Other); CESC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg05535760 chr7:792225 HEATR2 0.41 5.39 0.31 1.56e-7 Perceived unattractiveness to mosquitoes; CESC cis rs9388451 0.537 rs1739383 chr6:126098915 G/T cg05901451 chr6:126070800 HEY2 -0.57 -8.23 -0.45 8.71e-15 Brugada syndrome; CESC cis rs929354 0.742 rs2006844 chr7:157002851 G/A cg05182265 chr7:156933206 UBE3C -0.49 -7.25 -0.41 4.51e-12 Body mass index; CESC cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg22834771 chr12:69754056 YEATS4 -0.48 -6.38 -0.36 7.9e-10 Blood protein levels; CESC cis rs933688 1.000 rs332529 chr5:90789470 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 11.1 0.56 9e-24 Smoking behavior; CESC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg11663144 chr21:46675770 NA -0.63 -9.83 -0.52 1.24e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3733585 0.673 rs6850143 chr4:9958924 T/C cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg06634786 chr22:41940651 POLR3H -0.68 -6.73 -0.38 1.03e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs17784882 0.521 rs11713693 chr3:47074906 T/C cg27129171 chr3:47204927 SETD2 -0.65 -9.38 -0.5 3.19e-18 QT interval; CESC cis rs9583531 0.689 rs9588247 chr13:111375571 G/T cg15841412 chr13:111365552 ING1 -0.44 -5.4 -0.31 1.47e-7 Coronary artery disease; CESC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC trans rs1728785 1.000 rs1728773 chr16:68563644 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC trans rs1814175 0.817 rs7932683 chr11:49983640 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -21.34 -0.8 1.71e-59 Height; CESC cis rs78456975 1.000 rs78456975 chr2:1554190 T/G cg01028140 chr2:1542097 TPO -0.58 -5.9 -0.34 1.1e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs17431357 0.737 rs73230332 chr12:121024975 G/A cg25045489 chr12:120971538 RNF10 -0.9 -5.23 -0.31 3.44e-7 Insulin resistance/response; CESC cis rs2228479 0.867 rs17784386 chr16:89947457 A/G cg14709524 chr16:89940631 TCF25 0.74 5.75 0.33 2.43e-8 Skin colour saturation; CESC cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg05585544 chr11:47624801 NA -0.48 -7.0 -0.39 2.16e-11 Subjective well-being; CESC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg25036284 chr2:26402008 FAM59B -0.59 -6.88 -0.39 4.37e-11 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17766062 chr2:75062663 HK2 -0.43 -6.02 -0.35 5.75e-9 Gambling; CESC cis rs854765 0.583 rs4925130 chr17:17807858 G/A cg16928487 chr17:17741425 SREBF1 -0.59 -10.24 -0.53 5.94e-21 Total body bone mineral density; CESC cis rs3820068 0.608 rs12760450 chr1:16037282 G/A cg17385448 chr1:15911702 AGMAT 0.38 6.04 0.35 5.22e-9 Systolic blood pressure; CESC cis rs7917772 0.565 rs1043450 chr10:104434209 A/G cg22532475 chr10:104410764 TRIM8 -0.43 -6.7 -0.38 1.21e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs60843830 0.928 rs62114494 chr2:211317 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 7.95 0.44 5.46e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs5753618 0.583 rs5749270 chr22:31812853 C/T cg00478049 chr22:31556069 RNF185 -0.43 -5.11 -0.3 6.22e-7 Colorectal cancer; CESC cis rs4728302 0.869 rs10808273 chr7:133597691 G/C cg10665199 chr7:133106180 EXOC4 0.42 5.83 0.34 1.58e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7618501 0.501 rs35275715 chr3:49959148 A/G cg24110177 chr3:50126178 RBM5 -0.55 -7.72 -0.43 2.39e-13 Intelligence (multi-trait analysis); CESC cis rs10876993 0.928 rs1689586 chr12:58079586 A/T cg18357645 chr12:58087776 OS9 0.63 10.52 0.54 7.44e-22 Celiac disease or Rheumatoid arthritis; CESC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg23283495 chr1:209979779 IRF6 0.51 5.95 0.34 8.33e-9 Cleft lip with or without cleft palate; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24568548 chr11:43544500 NA -0.49 -6.95 -0.39 2.83e-11 Gut microbiota (bacterial taxa); CESC cis rs6546550 0.901 rs3771531 chr2:70164034 T/C cg02498382 chr2:70120550 SNRNP27 -0.41 -7.13 -0.4 9.44e-12 Prevalent atrial fibrillation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13937608 chr10:6131228 RBM17 0.55 6.11 0.35 3.46e-9 Gut microbiome composition (summer); CESC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg24675658 chr1:53192096 ZYG11B 0.55 6.9 0.39 3.8e-11 Monocyte count; CESC cis rs7789940 1.000 rs7789940 chr7:75951230 A/G cg10167463 chr7:75959203 YWHAG -0.54 -6.63 -0.38 1.9e-10 Multiple sclerosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19886106 chr8:144776541 ZNF707 0.51 7.47 0.42 1.16e-12 Fibrinogen levels; CESC trans rs2727020 0.894 rs3862342 chr11:49357043 C/T cg15704280 chr7:45808275 SEPT13 -0.75 -9.28 -0.5 6.33e-18 Coronary artery disease; CESC cis rs533123 0.877 rs1042114 chr1:29138975 G/T cg08366446 chr1:29138936 OPRD1 0.51 5.08 0.3 7.02e-7 Schizophrenia; CESC cis rs11958404 0.932 rs7706111 chr5:157416053 C/T cg05962755 chr5:157440814 NA 0.48 5.59 0.32 5.75e-8 IgG glycosylation; CESC cis rs8067545 0.750 rs4925079 chr17:19986861 T/A cg13482628 chr17:19912719 NA 0.37 5.1 0.3 6.5e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21503093 chr16:10674468 EMP2 0.56 6.43 0.37 6.06e-10 Gut microbiome composition (summer); CESC cis rs9549367 0.789 rs6577034 chr13:113879900 T/C cg18105134 chr13:113819100 PROZ -0.7 -9.13 -0.49 1.87e-17 Platelet distribution width; CESC cis rs6582630 0.519 rs8186992 chr12:38325848 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.31 0.53 3.6e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs959260 0.765 rs12945469 chr17:73372243 G/A cg20590849 chr17:73267439 MIF4GD -0.58 -6.56 -0.37 2.78e-10 Systemic lupus erythematosus; CESC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg07308232 chr7:1071921 C7orf50 -0.59 -8.29 -0.45 5.69e-15 Longevity;Endometriosis; CESC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.654 rs11078400 chr17:17757728 A/G cg09796270 chr17:17721594 SREBF1 -0.4 -5.75 -0.33 2.43e-8 Total body bone mineral density; CESC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg25767906 chr1:53392781 SCP2 0.42 5.77 0.33 2.21e-8 Monocyte count; CESC trans rs7824557 0.564 rs2736300 chr8:11235579 T/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.08 -0.35 4.21e-9 Retinal vascular caliber; CESC cis rs1707322 0.752 rs11211171 chr1:46168642 A/G cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg10074409 chr1:209979377 IRF6 0.35 5.67 0.33 3.71e-8 Cleft lip with or without cleft palate; CESC cis rs9479482 0.789 rs12204988 chr6:150339315 T/G cg03788504 chr6:150331562 NA -0.36 -7.05 -0.4 1.55e-11 Alopecia areata; CESC cis rs1559088 0.948 rs9304844 chr19:33579935 G/T cg17764715 chr19:33622953 WDR88 0.52 6.87 0.39 4.56e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs10791097 0.967 rs10791099 chr11:130718813 G/C cg12179176 chr11:130786555 SNX19 0.58 8.4 0.46 2.83e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.96e-10 Bipolar disorder; CESC cis rs6570726 0.935 rs585292 chr6:145862228 T/C cg23711669 chr6:146136114 FBXO30 0.8 11.78 0.59 4.84e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs9309473 0.607 rs7604588 chr2:73571417 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.27 -0.36 1.43e-9 Metabolite levels; CESC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg18230493 chr5:56204884 C5orf35 -0.74 -8.67 -0.47 4.37e-16 Initial pursuit acceleration; CESC cis rs7666738 0.716 rs1426660 chr4:98876792 T/A cg17366294 chr4:99064904 C4orf37 0.55 7.72 0.43 2.38e-13 Colonoscopy-negative controls vs population controls; CESC cis rs6429082 0.818 rs704722 chr1:235669988 G/A cg26050004 chr1:235667680 B3GALNT2 0.66 8.15 0.45 1.43e-14 Adiposity; CESC cis rs12618769 0.597 rs10199199 chr2:99061834 T/C cg10123293 chr2:99228465 UNC50 0.42 5.62 0.33 4.91e-8 Bipolar disorder; CESC cis rs362272 0.524 rs2749781 chr4:3346617 T/C cg08886695 chr4:3369023 RGS12 -0.44 -5.84 -0.34 1.53e-8 Serum sulfate level; CESC cis rs9905704 0.681 rs887206 chr17:56575084 G/C cg12560992 chr17:57184187 TRIM37 -0.65 -5.99 -0.35 6.85e-9 Testicular germ cell tumor; CESC trans rs2797160 0.684 rs1832937 chr6:125985934 A/G cg05039488 chr6:79577232 IRAK1BP1 0.45 6.18 0.35 2.39e-9 Endometrial cancer; CESC cis rs838147 0.508 rs507711 chr19:49208564 C/T cg21064579 chr19:49206444 FUT2 0.44 6.08 0.35 4.21e-9 Dietary macronutrient intake; CESC cis rs4909189 0.957 rs71547529 chr7:158135469 G/T cg25566285 chr7:158114605 PTPRN2 0.44 5.73 0.33 2.69e-8 Response to amphetamines; CESC cis rs1801251 1.000 rs13004406 chr2:233584557 A/T cg08000102 chr2:233561755 GIGYF2 -0.69 -9.67 -0.51 3.82e-19 Coronary artery disease; CESC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Depression; CESC cis rs8028182 0.636 rs4299117 chr15:75789444 C/T cg20655648 chr15:75932815 IMP3 0.47 5.87 0.34 1.33e-8 Sudden cardiac arrest; CESC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg05863683 chr7:1912471 MAD1L1 0.38 5.85 0.34 1.42e-8 Bipolar disorder and schizophrenia; CESC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -7.09 -0.4 1.2e-11 Bipolar disorder and schizophrenia; CESC cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg22862634 chr11:62369728 EML3;MTA2 0.55 7.65 0.43 3.83e-13 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.49 0.32 9.42e-8 Major depressive disorder; CESC cis rs11718455 0.960 rs34179760 chr3:44002303 A/G cg08738300 chr3:44038990 NA 0.46 6.13 0.35 3.17e-9 Coronary artery disease; CESC cis rs2115630 0.653 rs61394864 chr15:85170174 T/C cg11189052 chr15:85197271 WDR73 -0.45 -6.11 -0.35 3.49e-9 P wave terminal force; CESC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg10792982 chr14:105748885 BRF1 0.42 5.59 0.32 5.74e-8 Mean platelet volume;Platelet distribution width; CESC cis rs7259376 0.905 rs11879791 chr19:22536939 A/G cg02657401 chr19:22469223 NA -0.26 -5.23 -0.31 3.38e-7 Menopause (age at onset); CESC cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg03467027 chr4:99064603 C4orf37 0.41 5.03 0.3 9.03e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7937682 0.889 rs11213971 chr11:111529829 A/G cg09085632 chr11:111637200 PPP2R1B -1.0 -16.54 -0.71 1.09e-42 Primary sclerosing cholangitis; CESC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg20307385 chr11:47447363 PSMC3 0.63 7.77 0.43 1.76e-13 Subjective well-being; CESC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -5.57 -0.32 6.25e-8 Electroencephalogram traits; CESC cis rs4253772 0.872 rs11704508 chr22:46638540 A/G cg00784671 chr22:46762841 CELSR1 -0.57 -5.61 -0.33 5.1e-8 LDL cholesterol;Cholesterol, total; CESC trans rs2072510 0.683 rs2540487 chr12:96429783 C/T cg03453916 chr7:31174468 NA 0.41 6.2 0.36 2.12e-9 Metabolite levels (small molecules and protein measures); CESC cis rs757110 0.933 rs7124355 chr11:17412960 C/T cg15432903 chr11:17409602 KCNJ11 -0.47 -5.91 -0.34 1.05e-8 Type 2 diabetes; CESC cis rs7666738 0.546 rs6827131 chr4:98744810 C/G cg17366294 chr4:99064904 C4orf37 0.49 6.1 0.35 3.68e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4727027 0.933 rs12704062 chr7:148827865 G/A cg23583168 chr7:148888333 NA -0.79 -12.21 -0.6 1.63e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6751744 0.513 rs7563368 chr2:160457075 C/T cg08347373 chr2:160653686 CD302 0.32 5.23 0.31 3.5e-7 Dysphagia; CESC cis rs959260 1.000 rs4789183 chr17:73380221 G/A cg12999837 chr17:73267436 MIF4GD -0.48 -5.58 -0.32 5.89e-8 Systemic lupus erythematosus; CESC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.85 0.65 3.59e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9916302 0.706 rs590051 chr17:37446571 T/C cg07936489 chr17:37558343 FBXL20 0.92 10.37 0.54 2.23e-21 Glomerular filtration rate (creatinine); CESC trans rs877282 0.733 rs11253342 chr10:765072 A/G cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs472109 0.934 rs360156 chr11:9756724 T/C cg03108697 chr11:9732066 SWAP70 -0.34 -5.12 -0.3 5.9e-7 Coronary artery disease; CESC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg04944784 chr2:26401820 FAM59B -0.74 -8.33 -0.46 4.38e-15 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07454192 chr8:74888262 TMEM70 -0.44 -6.65 -0.38 1.65e-10 Gambling; CESC cis rs7520050 0.966 rs1768816 chr1:46528599 T/C cg03146154 chr1:46216737 IPP -0.45 -5.75 -0.33 2.41e-8 Red blood cell count;Reticulocyte count; CESC cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg15782153 chr7:917662 C7orf20 0.5 5.34 0.31 2.04e-7 Cerebrospinal P-tau181p levels; CESC cis rs2204008 0.712 rs12371182 chr12:38321143 A/C cg13010199 chr12:38710504 ALG10B 0.52 6.31 0.36 1.19e-9 Bladder cancer; CESC cis rs7208859 0.623 rs122898 chr17:28905254 C/T cg19761014 chr17:28927070 LRRC37B2 -0.84 -6.69 -0.38 1.29e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 0.830 rs10005173 chr4:98816062 T/C cg05340658 chr4:99064831 C4orf37 0.72 10.44 0.54 1.3e-21 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4722166 0.630 rs12700390 chr7:22777129 G/T cg26061582 chr7:22766209 IL6 0.51 5.55 0.32 6.82e-8 Lung cancer; CESC trans rs7824557 0.527 rs4631425 chr8:11239054 C/T cg15556689 chr8:8085844 FLJ10661 -0.48 -6.09 -0.35 3.85e-9 Retinal vascular caliber; CESC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg27125505 chr17:43679177 LOC644172 0.5 6.51 0.37 3.7e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1728785 0.901 rs11642189 chr16:68583990 G/A cg02972257 chr16:68554789 NA -0.54 -6.27 -0.36 1.45e-9 Ulcerative colitis; CESC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg00684032 chr4:1343700 KIAA1530 0.38 5.38 0.31 1.62e-7 Obesity-related traits; CESC cis rs6570726 0.935 rs388394 chr6:145852689 C/T cg23711669 chr6:146136114 FBXO30 0.78 11.38 0.57 1.06e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs6466055 0.720 rs1204066 chr7:104971987 G/T cg04380332 chr7:105027541 SRPK2 0.4 5.21 0.3 3.78e-7 Schizophrenia; CESC cis rs1665050 0.534 rs7167050 chr15:59240801 A/C cg05156742 chr15:59063176 FAM63B 0.5 6.34 0.36 1e-9 Atopic dermatitis; CESC cis rs12618769 0.597 rs4851138 chr2:99065464 A/C cg10123293 chr2:99228465 UNC50 0.41 5.42 0.32 1.31e-7 Bipolar disorder; CESC cis rs7188697 0.922 rs37060 chr16:58566304 C/T cg21335942 chr16:58549945 SETD6 0.48 5.68 0.33 3.52e-8 QT interval; CESC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.38 5.15 0.3 5.09e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06758143 chr1:26798177 HMGN2 0.65 7.5 0.42 9.94e-13 Gut microbiome composition (summer); CESC cis rs7937682 0.632 rs1045282 chr11:111754574 A/C cg22437258 chr11:111473054 SIK2 -0.5 -5.53 -0.32 7.6e-8 Primary sclerosing cholangitis; CESC cis rs12477438 0.765 rs62154861 chr2:99590235 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -10.68 -0.55 2.27e-22 Chronic sinus infection; CESC cis rs11792861 0.781 rs11793272 chr9:111762102 G/A cg13535736 chr9:111863775 C9orf5 -0.46 -6.04 -0.35 5.1e-9 Menarche (age at onset); CESC cis rs6867032 0.527 rs13190594 chr5:2012474 T/C cg26168224 chr5:2018326 NA 0.78 14.21 0.66 1.82e-34 Gut microbiome composition (winter); CESC cis rs72781680 0.848 rs56371415 chr2:23932603 C/G cg20701182 chr2:24300061 SF3B14 0.77 6.9 0.39 3.84e-11 Lymphocyte counts; CESC cis rs9916302 0.861 rs12150493 chr17:37586154 T/C cg07936489 chr17:37558343 FBXL20 -0.8 -11.5 -0.58 4.2e-25 Glomerular filtration rate (creatinine); CESC cis rs763014 1.000 rs763014 chr16:675680 T/C cg00908189 chr16:619842 PIGQ 0.63 8.8 0.48 1.86e-16 Height; CESC cis rs11098499 0.913 rs56122576 chr4:120129336 A/G cg09307838 chr4:120376055 NA 0.79 10.07 0.53 2.04e-20 Corneal astigmatism; CESC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg12419862 chr22:24373484 LOC391322 0.72 10.33 0.54 3e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6460942 1.000 rs62448562 chr7:12398785 T/C cg20607287 chr7:12443886 VWDE -0.8 -8.85 -0.48 1.3e-16 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12138063 chr19:16607096 C19orf44;CALR3 0.58 6.85 0.39 5.02e-11 Gut microbiome composition (summer); CESC cis rs2370759 1.000 rs77165999 chr10:32577131 T/C cg05361325 chr10:32636312 EPC1 -0.55 -5.18 -0.3 4.39e-7 Sexual dysfunction (female); CESC cis rs7666738 0.830 rs7659006 chr4:98934529 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC trans rs3942852 0.774 rs1039481 chr11:48182237 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -8.67 -0.47 4.34e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg24549020 chr5:56110836 MAP3K1 0.66 7.33 0.41 2.81e-12 Initial pursuit acceleration; CESC cis rs2718058 0.519 rs2598072 chr7:37875319 A/C cg24998770 chr7:37888106 TXNDC3 0.4 5.85 0.34 1.41e-8 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11857246 chr1:11741390 MAD2L2 0.59 6.32 0.36 1.1e-9 Gut microbiome composition (summer); CESC cis rs710216 0.917 rs4660691 chr1:43417150 T/G cg03128534 chr1:43423976 SLC2A1 -0.56 -6.52 -0.37 3.52e-10 Red cell distribution width; CESC cis rs3008870 1.000 rs11208979 chr1:67442275 C/T cg02640540 chr1:67518911 SLC35D1 -0.51 -5.58 -0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs66530629 0.761 rs7519508 chr1:25147750 G/A cg22509179 chr1:25234806 RUNX3 -0.42 -5.38 -0.31 1.63e-7 Plateletcrit; CESC cis rs8072100 0.688 rs8075843 chr17:45442363 C/T cg25173405 chr17:45401733 C17orf57 -0.44 -5.48 -0.32 9.98e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7259376 0.936 rs10423736 chr19:22596132 C/T cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.94e-7 Menopause (age at onset); CESC cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg18512352 chr11:47633146 NA -0.51 -7.28 -0.41 3.78e-12 Subjective well-being; CESC cis rs959260 0.800 rs9895739 chr17:73399916 C/T cg12999837 chr17:73267436 MIF4GD -0.48 -5.54 -0.32 7.12e-8 Systemic lupus erythematosus; CESC cis rs2180341 1.000 rs3798850 chr6:127613966 C/T cg27446573 chr6:127587934 RNF146 1.08 16.13 0.7 3.14e-41 Breast cancer; CESC cis rs561341 1.000 rs542132 chr17:30307193 A/T cg12193833 chr17:30244370 NA -0.7 -6.49 -0.37 4.19e-10 Hip circumference adjusted for BMI; CESC cis rs763121 0.853 rs5750627 chr22:38982321 A/G cg21395723 chr22:39101663 GTPBP1 0.48 6.41 0.37 6.78e-10 Menopause (age at onset); CESC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg05564831 chr3:52568323 NT5DC2 0.48 7.64 0.42 4.06e-13 Bipolar disorder; CESC cis rs2777491 0.957 rs7163788 chr15:41704789 A/G cg20272979 chr15:41787780 ITPKA 0.46 6.78 0.38 7.74e-11 Ulcerative colitis; CESC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg22920501 chr2:26401640 FAM59B 0.91 10.38 0.54 2.08e-21 Gut microbiome composition (summer); CESC trans rs35110281 0.776 rs2838316 chr21:44990036 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 7.85 0.43 1.06e-13 Mean corpuscular volume; CESC cis rs9522267 0.707 rs9522282 chr13:112222410 T/C cg10483660 chr13:112241077 NA -0.32 -5.39 -0.31 1.53e-7 Hepatitis; CESC cis rs78707713 0.560 rs61848398 chr10:71226103 G/A cg12610070 chr10:71211762 TSPAN15 -0.34 -7.07 -0.4 1.4e-11 Venous thromboembolism; CESC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 3.98e-12 Major depressive disorder; CESC cis rs11650494 0.808 rs76366926 chr17:47396628 T/C cg08112188 chr17:47440006 ZNF652 1.31 8.51 0.46 1.31e-15 Prostate cancer; CESC cis rs2730245 0.618 rs859781 chr7:158661758 G/A cg01943577 chr7:158741284 NA -0.45 -5.97 -0.34 7.49e-9 Height; CESC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.6 6.8 0.39 6.87e-11 Lung function (FEV1/FVC); CESC cis rs7116495 1.000 rs10751193 chr11:71785356 A/C cg26138937 chr11:71823887 C11orf51 -0.84 -6.79 -0.38 7.37e-11 Severe influenza A (H1N1) infection; CESC cis rs2933343 0.700 rs1680778 chr3:128614185 A/C cg11901034 chr3:128598214 ACAD9 -0.4 -5.76 -0.33 2.38e-8 IgG glycosylation; CESC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg21770322 chr7:97807741 LMTK2 0.54 8.17 0.45 1.31e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs12928939 0.518 rs12445564 chr16:71943309 C/T cg03805757 chr16:71968109 PKD1L3 -0.58 -6.67 -0.38 1.52e-10 Post bronchodilator FEV1; CESC cis rs1018836 0.608 rs1033348 chr8:91464169 C/G cg16814680 chr8:91681699 NA -0.51 -7.03 -0.4 1.72e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs17666538 0.591 rs2878547 chr8:603416 G/A cg02524346 chr8:600233 NA 0.77 6.32 0.36 1.12e-9 IgG glycosylation; CESC cis rs1620921 0.505 rs4709467 chr6:161203079 G/A cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs559928 0.606 rs12417635 chr11:63912728 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 6.06 0.35 4.55e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs7944584 0.655 rs2856653 chr11:47361084 T/C cg20307385 chr11:47447363 PSMC3 -0.6 -7.34 -0.41 2.56e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg24829409 chr8:58192753 C8orf71 -0.55 -6.86 -0.39 4.86e-11 Developmental language disorder (linguistic errors); CESC cis rs2228479 0.557 rs57071566 chr16:89889327 T/G cg04013166 chr16:89971882 TCF25 0.67 5.48 0.32 1.01e-7 Skin colour saturation; CESC cis rs1005277 0.589 rs2749624 chr10:38529865 A/G cg25427524 chr10:38739819 LOC399744 -0.72 -10.76 -0.55 1.2e-22 Extrinsic epigenetic age acceleration; CESC cis rs412050 1.000 rs412050 chr22:22307519 C/G cg17089214 chr22:22089827 YPEL1 0.63 6.02 0.35 5.9e-9 Attention deficit hyperactivity disorder; CESC cis rs7116495 0.609 rs674319 chr11:71775391 T/C cg26138937 chr11:71823887 C11orf51 -1.32 -8.2 -0.45 1.04e-14 Severe influenza A (H1N1) infection; CESC cis rs2952156 1.000 rs2952156 chr17:37876835 A/G cg20243544 chr17:37824526 PNMT 0.63 7.55 0.42 6.89e-13 Asthma; CESC cis rs939574 0.929 rs10190834 chr2:220070301 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.54 -5.26 -0.31 3.03e-7 Platelet distribution width; CESC cis rs2354432 0.607 rs7537483 chr1:146709877 C/G cg25205988 chr1:146714368 CHD1L 1.01 7.96 0.44 4.9e-14 Mitochondrial DNA levels; CESC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg11764359 chr7:65958608 NA -0.78 -11.17 -0.57 5.37e-24 Aortic root size; CESC cis rs6570726 0.846 rs446031 chr6:145885592 C/T cg05347473 chr6:146136440 FBXO30 0.46 6.12 0.35 3.32e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg24308560 chr3:49941425 MST1R -0.64 -9.35 -0.5 3.91e-18 Intelligence (multi-trait analysis); CESC cis rs10899021 1.000 rs10899025 chr11:74367040 G/A cg25880958 chr11:74394337 NA -0.73 -7.2 -0.4 6.33e-12 Response to metformin (IC50); CESC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg25072359 chr17:41440525 NA 0.48 6.52 0.37 3.45e-10 Menopause (age at onset); CESC cis rs12681288 0.792 rs12678495 chr8:1000858 C/G cg15309053 chr8:964076 NA 0.32 5.46 0.32 1.11e-7 Schizophrenia; CESC cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg11663144 chr21:46675770 NA -0.62 -9.42 -0.5 2.26e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs67460515 0.892 rs4856769 chr3:161004549 C/A cg03342759 chr3:160939853 NMD3 -0.52 -7.0 -0.4 2.05e-11 Parkinson's disease; CESC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.47 0.37 4.63e-10 Bipolar disorder; CESC cis rs644799 1.000 rs1784135 chr11:95531748 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6088580 0.609 rs2378205 chr20:33110803 C/G cg24642439 chr20:33292090 TP53INP2 0.51 6.62 0.38 1.99e-10 Glomerular filtration rate (creatinine); CESC cis rs2204008 0.560 rs1315354 chr12:38165716 A/G cg26384229 chr12:38710491 ALG10B -0.4 -5.46 -0.32 1.11e-7 Bladder cancer; CESC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.28 0.31 2.66e-7 Bipolar disorder; CESC cis rs6541297 1.000 rs6541296 chr1:230281953 A/G cg20703242 chr1:230279135 GALNT2 0.73 11.12 0.56 8.07e-24 Coronary artery disease; CESC trans rs1829883 0.648 rs2511925 chr5:98721872 G/A cg23861655 chr4:57411219 NA 0.38 6.19 0.36 2.24e-9 Hemostatic factors and hematological phenotypes; CESC cis rs9611565 0.921 rs3927 chr22:41722864 A/G cg06481639 chr22:41940642 POLR3H -0.6 -6.49 -0.37 4.22e-10 Vitiligo; CESC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg22143856 chr6:28129313 ZNF389 0.38 5.41 0.32 1.41e-7 Cardiac Troponin-T levels; CESC cis rs9457247 0.765 rs6904946 chr6:167433948 C/T cg07741184 chr6:167504864 NA -0.36 -6.56 -0.37 2.89e-10 Crohn's disease; CESC trans rs2273788 1.000 rs2273788 chr9:114348617 C/T cg18395993 chr1:249152672 ZNF692 -0.61 -6.18 -0.35 2.41e-9 Monocyte count; CESC cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg21385522 chr1:16154831 NA 0.62 7.52 0.42 8.52e-13 Dilated cardiomyopathy; CESC cis rs2380220 0.574 rs9374322 chr6:95998994 G/A cg04719120 chr6:96025338 MANEA 0.47 5.39 0.31 1.6e-7 Behavioural disinhibition (generation interaction); CESC cis rs71636778 0.543 rs71636796 chr1:27243095 T/C cg12203394 chr1:27248618 NUDC 0.66 5.55 0.32 6.85e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs60154123 0.772 rs815358 chr1:210430437 A/G cg22029157 chr1:209979665 IRF6 0.48 5.61 0.33 5.05e-8 Coronary artery disease; CESC trans rs11098499 0.739 rs2203039 chr4:120132347 T/C cg25214090 chr10:38739885 LOC399744 -0.53 -6.99 -0.39 2.16e-11 Corneal astigmatism; CESC cis rs1371867 0.846 rs1660338 chr8:101242757 C/G cg11906718 chr8:101322791 RNF19A 0.43 5.63 0.33 4.5e-8 Atrioventricular conduction; CESC cis rs7216064 1.000 rs4791299 chr17:65930937 A/G cg07042672 chr17:66097459 LOC651250 -0.6 -7.44 -0.42 1.39e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.5 0.42 9.5e-13 Tonsillectomy; CESC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.06 0.3 7.99e-7 Colonoscopy-negative controls vs population controls; CESC cis rs897984 0.571 rs7184567 chr16:31021078 C/T cg00531865 chr16:30841666 NA -0.41 -5.79 -0.33 2.03e-8 Dementia with Lewy bodies; CESC cis rs3925075 0.934 rs9673522 chr16:31347648 T/C cg02846316 chr16:31340340 ITGAM 0.41 6.52 0.37 3.54e-10 IgA nephropathy; CESC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg00745463 chr17:30367425 LRRC37B 0.57 5.64 0.33 4.31e-8 Hip circumference adjusted for BMI; CESC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.37 -0.31 1.76e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7927592 0.763 rs7120876 chr11:68261398 C/G cg20283391 chr11:68216788 NA -0.45 -5.64 -0.33 4.46e-8 Total body bone mineral density; CESC cis rs4906332 1.000 rs35126287 chr14:103959432 A/G cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.49e-10 Coronary artery disease; CESC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg18876405 chr7:65276391 NA 0.5 6.64 0.38 1.75e-10 Aortic root size; CESC cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg24818145 chr4:99064322 C4orf37 0.39 5.06 0.3 7.89e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4481887 0.636 rs10788761 chr1:248410663 C/T cg00666640 chr1:248458726 OR2T12 0.35 5.47 0.32 1.07e-7 Common traits (Other); CESC cis rs4253772 0.575 rs9615956 chr22:46749634 C/T cg00784671 chr22:46762841 CELSR1 -0.7 -6.37 -0.36 8.41e-10 LDL cholesterol;Cholesterol, total; CESC cis rs763121 0.853 rs2076028 chr22:39150450 G/A cg14440974 chr22:39074834 NA -0.39 -5.37 -0.31 1.69e-7 Menopause (age at onset); CESC cis rs4268898 0.516 rs7597149 chr2:24371962 C/T cg20701182 chr2:24300061 SF3B14 -0.39 -5.32 -0.31 2.23e-7 Asthma; CESC cis rs2276314 1.000 rs2298715 chr18:33552425 T/C cg05985134 chr18:33552581 C18orf21 0.67 7.95 0.44 5.35e-14 Endometriosis;Drug-induced torsades de pointes; CESC trans rs3780486 0.846 rs12554995 chr9:33132044 A/G cg20290983 chr6:43655470 MRPS18A 0.99 18.35 0.75 4.06e-49 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05788994 chr16:53089097 CHD9 0.54 6.05 0.35 4.9e-9 Gut microbiome composition (summer); CESC cis rs7937682 0.889 rs1789355 chr11:111499718 T/C cg09085632 chr11:111637200 PPP2R1B -0.99 -15.77 -0.7 5.94e-40 Primary sclerosing cholangitis; CESC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg03188948 chr7:1209495 NA 0.73 7.17 0.4 7.66e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs67311347 1.000 rs28871903 chr3:40511094 T/G cg09455208 chr3:40491958 NA 0.5 8.19 0.45 1.15e-14 Renal cell carcinoma; CESC cis rs1215050 0.716 rs11940331 chr4:99054041 G/C cg17366294 chr4:99064904 C4orf37 0.43 5.59 0.32 5.7e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs3741151 0.773 rs73543000 chr11:73151774 T/C cg17517138 chr11:73019481 ARHGEF17 1.0 7.41 0.41 1.74e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs8072100 0.688 rs7221224 chr17:45419061 T/G cg25173405 chr17:45401733 C17orf57 0.42 5.2 0.3 4.03e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6982240 0.514 rs10095322 chr8:142262327 A/G cg27411547 chr8:142287226 NA -0.53 -7.32 -0.41 2.99e-12 Tonsillectomy; CESC cis rs17384381 1.000 rs12140935 chr1:85855716 G/A cg16011679 chr1:85725395 C1orf52 0.79 8.08 0.44 2.34e-14 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07878378 chr8:56987195 RPS20;SNORD54 -0.58 -6.33 -0.36 1.03e-9 Gut microbiome composition (summer); CESC cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg22633769 chr20:60982531 CABLES2 0.56 5.76 0.33 2.28e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg11890956 chr21:40555474 PSMG1 -1.16 -21.02 -0.79 2.18e-58 Cognitive function; CESC cis rs1153858 0.943 rs4774580 chr15:45652086 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.97 0.34 7.62e-9 Homoarginine levels; CESC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.91e-8 Lung cancer; CESC cis rs11864453 0.826 rs2074626 chr16:72139184 C/A cg16558253 chr16:72132732 DHX38 -0.6 -9.61 -0.51 5.77e-19 Fibrinogen levels; CESC cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.78 8.92 0.48 7.63e-17 Alzheimer's disease; CESC cis rs9640161 0.830 rs36069544 chr7:150061538 G/A cg10018233 chr7:150070692 REPIN1 0.37 5.67 0.33 3.82e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs7914558 0.966 rs7096269 chr10:104736721 A/G cg04362960 chr10:104952993 NT5C2 0.44 5.69 0.33 3.32e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4595586 0.967 rs11169807 chr12:39244161 A/G cg26384229 chr12:38710491 ALG10B 0.37 5.45 0.32 1.13e-7 Morning vs. evening chronotype; CESC cis rs11822910 0.645 rs7122734 chr11:57190420 C/T cg00522883 chr11:57194120 SLC43A3 -0.45 -5.43 -0.32 1.29e-7 Platelet distribution width; CESC trans rs208520 1.000 rs12190187 chr6:66973207 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 9.39 0.5 2.78e-18 Exhaled nitric oxide output; CESC cis rs3820928 0.874 rs4144328 chr2:227790187 A/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.7 -0.33 3.25e-8 Pulmonary function; CESC cis rs5758659 0.652 rs133326 chr22:42406885 G/A cg15557168 chr22:42548783 NA -0.42 -6.27 -0.36 1.47e-9 Cognitive function; CESC cis rs9467711 0.606 rs9393715 chr6:26375645 G/A cg12826209 chr6:26865740 GUSBL1 0.64 5.25 0.31 3.2e-7 Autism spectrum disorder or schizophrenia; CESC cis rs2242073 0.660 rs12464752 chr2:208996677 G/A cg10392614 chr2:208977121 NA 0.38 5.15 0.3 5.07e-7 Attention deficit hyperactivity disorder; CESC cis rs9584850 0.520 rs10508036 chr13:99157398 C/G cg20750642 chr13:99100586 FARP1 0.4 5.77 0.33 2.19e-8 Neuroticism; CESC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg02776659 chr21:47717406 C21orf57 -0.37 -5.05 -0.3 8.24e-7 Testicular germ cell tumor; CESC cis rs703842 1.000 rs4646536 chr12:58157988 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.71 9.27 0.5 6.51e-18 Multiple sclerosis; CESC cis rs5747327 0.835 rs181396 chr22:18224155 A/G cg19898043 chr22:18121309 BCL2L13 0.41 5.18 0.3 4.34e-7 Myeloid white cell count;Granulocyte count; CESC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg15445000 chr17:37608096 MED1 0.41 6.82 0.39 6.31e-11 Glomerular filtration rate (creatinine); CESC trans rs7095944 0.614 rs10901817 chr10:126443404 A/T cg27222157 chr11:66382978 RBM14 0.38 6.13 0.35 3.17e-9 Asthma; CESC cis rs870825 0.616 rs6552809 chr4:185643984 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.13 0.4 9.71e-12 Blood protein levels; CESC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg10570241 chr7:158785291 NA 0.31 5.17 0.3 4.51e-7 Facial morphology (factor 20); CESC cis rs754466 0.606 rs11002306 chr10:79591519 A/T cg17075019 chr10:79541650 NA -0.86 -14.02 -0.65 8.85e-34 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs723080 1.000 rs2425427 chr20:39349489 C/T cg17737388 chr1:85724454 C1orf52 -0.38 -6.07 -0.35 4.43e-9 Paneth cell defects in Crohn's disease; CESC cis rs9837602 1.000 rs793496 chr3:99507254 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.52 -7.14 -0.4 8.78e-12 Breast cancer; CESC cis rs9788682 1.000 rs7181245 chr15:78814389 C/T cg06917634 chr15:78832804 PSMA4 -0.56 -6.64 -0.38 1.72e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg27347728 chr4:17578864 LAP3 0.5 5.76 0.33 2.29e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg19717773 chr7:2847554 GNA12 -0.52 -8.16 -0.45 1.32e-14 Height; CESC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg18876405 chr7:65276391 NA 0.53 7.28 0.41 3.9e-12 Aortic root size; CESC cis rs1499614 1.000 rs2659913 chr7:66157336 T/A cg12463550 chr7:65579703 CRCP 0.73 5.73 0.33 2.78e-8 Gout; CESC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg18240062 chr17:79603768 NPLOC4 0.54 7.11 0.4 1.06e-11 Eye color traits; CESC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs11229555 0.645 rs12786744 chr11:58177549 T/C cg15696309 chr11:58395628 NA -0.42 -5.07 -0.3 7.51e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs4953076 0.533 rs10173126 chr2:44446492 T/C cg04920474 chr2:44395004 PPM1B 0.58 7.29 0.41 3.52e-12 Height; CESC cis rs6831352 0.918 rs2602896 chr4:100046207 C/T cg13256891 chr4:100009986 ADH5 -0.78 -8.84 -0.48 1.36e-16 Alcohol dependence; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12271800 chr19:59028764 ZBTB45 -0.46 -6.18 -0.35 2.46e-9 Gut microbiota (bacterial taxa); CESC cis rs2274273 0.588 rs9919932 chr14:55814080 A/G cg04306507 chr14:55594613 LGALS3 0.29 5.13 0.3 5.66e-7 Protein biomarker; CESC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg13012494 chr21:47604986 C21orf56 0.48 6.37 0.36 8.51e-10 Testicular germ cell tumor; CESC cis rs6089584 0.627 rs13045575 chr20:60565596 G/A cg24733560 chr20:60626293 TAF4 0.42 6.28 0.36 1.35e-9 Body mass index; CESC cis rs734999 0.549 rs2764845 chr1:2528999 G/T cg20673091 chr1:2541236 MMEL1 -0.44 -7.49 -0.42 1.01e-12 Ulcerative colitis; CESC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -6.75 -0.38 9.55e-11 Bipolar disorder; CESC cis rs11997175 0.546 rs4545051 chr8:33608863 T/C ch.8.33884649F chr8:33765107 NA 0.57 7.47 0.42 1.15e-12 Body mass index; CESC trans rs1814175 0.791 rs10219223 chr11:49791468 A/T cg03929089 chr4:120376271 NA -0.9 -14.79 -0.67 1.7e-36 Height; CESC cis rs2073300 1.000 rs2207989 chr20:23446014 T/G cg12062639 chr20:23401060 NAPB 0.74 5.43 0.32 1.3e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1707322 1.000 rs10158032 chr1:46332701 T/C cg06784218 chr1:46089804 CCDC17 0.32 5.52 0.32 8.02e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9457247 0.715 rs6923582 chr6:167437162 T/A cg07741184 chr6:167504864 NA 0.36 6.41 0.37 6.69e-10 Crohn's disease; CESC cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg15017067 chr4:17643749 FAM184B 0.38 5.45 0.32 1.16e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs727505 1.000 rs56387611 chr7:124479180 G/A cg23710748 chr7:124431027 NA -0.48 -7.61 -0.42 4.76e-13 Lewy body disease; CESC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.2e-8 Major depressive disorder; CESC cis rs992157 0.798 rs7587220 chr2:219160864 C/A cg20019365 chr2:219134978 PNKD;AAMP -0.66 -8.66 -0.47 4.76e-16 Colorectal cancer; CESC cis rs7833790 0.553 rs9693128 chr8:82706128 A/G cg27398817 chr8:82754497 SNX16 -0.64 -8.96 -0.48 6.01e-17 Diastolic blood pressure; CESC cis rs9814567 0.964 rs9847788 chr3:134186496 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.49 -0.32 9.46e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg01448562 chr3:133502909 NA -0.47 -6.75 -0.38 9.3e-11 Iron status biomarkers; CESC cis rs17826219 0.500 rs9891256 chr17:29072692 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Body mass index; CESC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.41 5.13 0.3 5.57e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs1215050 0.765 rs181521 chr4:98745728 A/C cg05340658 chr4:99064831 C4orf37 0.51 6.65 0.38 1.63e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs662064 0.852 rs2056417 chr1:10581658 G/A cg20482658 chr1:10539492 PEX14 0.41 8.44 0.46 2.06e-15 Asthma; CESC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg06634786 chr22:41940651 POLR3H -0.65 -6.82 -0.39 6.01e-11 Vitiligo; CESC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg13206674 chr6:150067644 NUP43 0.42 5.89 0.34 1.19e-8 Lung cancer; CESC cis rs2404602 0.530 rs11072614 chr15:76967205 G/A cg00316803 chr15:76480434 C15orf27 0.4 5.56 0.32 6.66e-8 Blood metabolite levels; CESC cis rs6142102 0.602 rs4911399 chr20:32623418 C/A cg08999081 chr20:33150536 PIGU 0.33 5.03 0.3 9.11e-7 Skin pigmentation; CESC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg09699651 chr6:150184138 LRP11 0.4 5.3 0.31 2.45e-7 Lung cancer; CESC cis rs9291683 0.679 rs13137795 chr4:10051506 G/A cg02734326 chr4:10020555 SLC2A9 0.47 6.71 0.38 1.2e-10 Bone mineral density; CESC cis rs2625529 0.652 rs11072350 chr15:72464609 T/G cg16672083 chr15:72433130 SENP8 0.45 6.79 0.39 7.29e-11 Red blood cell count; CESC cis rs710216 0.843 rs2297972 chr1:43418026 C/T cg07803811 chr1:43423981 SLC2A1 -0.46 -5.25 -0.31 3.13e-7 Red cell distribution width; CESC cis rs1348850 0.526 rs78587445 chr2:178461339 G/T cg23306229 chr2:178417860 TTC30B -0.68 -5.8 -0.34 1.84e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3015497 0.789 rs3015498 chr14:51112824 T/C cg09863266 chr14:51125203 SAV1 -0.33 -5.17 -0.3 4.62e-7 Mean platelet volume; CESC cis rs4319547 1.000 rs7295397 chr12:123116209 C/T cg05707623 chr12:122985044 ZCCHC8 -0.58 -6.75 -0.38 9.06e-11 Body mass index; CESC cis rs6121246 0.567 rs6060263 chr20:30193110 T/C cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs8062405 0.655 rs7184597 chr16:28921809 T/C cg05966235 chr16:28915196 ATP2A1 -0.39 -5.57 -0.32 6.27e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg10556349 chr10:835070 NA 0.57 5.56 0.32 6.44e-8 Eosinophil percentage of granulocytes; CESC cis rs9913156 0.670 rs4416072 chr17:4570036 C/T cg19197139 chr17:4613644 ARRB2 0.87 10.12 0.53 1.45e-20 Lymphocyte counts; CESC cis rs11958404 0.615 rs7727924 chr5:157433736 A/G cg05962755 chr5:157440814 NA 0.4 5.74 0.33 2.54e-8 IgG glycosylation; CESC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs62005083 0.867 rs72725990 chr14:74633610 C/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.71 5.53 0.32 7.52e-8 Mean corpuscular volume; CESC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg11890956 chr21:40555474 PSMG1 -0.63 -8.11 -0.45 1.88e-14 Menarche (age at onset); CESC cis rs72772090 0.539 rs11748519 chr5:96119328 C/A cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.21 -0.3 3.74e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3105593 1.000 rs11070807 chr15:50974505 A/G cg08437265 chr15:50716283 USP8 0.45 5.92 0.34 1e-8 QT interval; CESC cis rs9486715 0.867 rs3849199 chr6:97049191 T/C cg06623918 chr6:96969491 KIAA0776 -0.96 -15.13 -0.68 1.08e-37 Headache; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13793354 chr5:70882903 MCCC2 -0.53 -6.8 -0.39 6.84e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.78 0.38 7.61e-11 Platelet count; CESC cis rs6665290 0.904 rs9727512 chr1:227185375 G/T cg10327440 chr1:227177885 CDC42BPA -1.2 -31.28 -0.89 6.16e-91 Myeloid white cell count; CESC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg18876405 chr7:65276391 NA -0.51 -7.05 -0.4 1.53e-11 Aortic root size; CESC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs1508086 0.695 rs10958508 chr8:57803673 A/C cg10342016 chr8:57802622 NA 0.29 5.04 0.3 8.47e-7 Hand grip strength; CESC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg24562669 chr7:97807699 LMTK2 0.51 7.57 0.42 6.13e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg14338887 chr6:42928500 GNMT 0.35 5.19 0.3 4.25e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7560272 0.501 rs12713798 chr2:73986421 C/T cg20560298 chr2:73613845 ALMS1 0.43 6.04 0.35 5.32e-9 Schizophrenia; CESC cis rs1670533 1.000 rs11247972 chr4:1060550 A/G cg04106633 chr4:1044584 NA 0.4 5.19 0.3 4.15e-7 Recombination rate (females); CESC cis rs10754283 0.967 rs10737707 chr1:90119304 A/G cg21401794 chr1:90099060 LRRC8C 0.66 8.77 0.47 2.18e-16 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2050392 0.931 rs2265187 chr10:30690844 C/T cg18806716 chr10:30721971 MAP3K8 -0.4 -5.66 -0.33 3.86e-8 Inflammatory bowel disease; CESC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg09177884 chr7:1199841 ZFAND2A -0.51 -6.68 -0.38 1.41e-10 Longevity;Endometriosis; CESC cis rs4718428 0.576 rs12698546 chr7:66266906 G/T cg25985355 chr7:65971099 NA -0.36 -5.21 -0.3 3.83e-7 Corneal structure; CESC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg17911788 chr17:44343683 NA 0.44 6.73 0.38 1.07e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg07507251 chr3:52567010 NT5DC2 0.42 7.24 0.41 4.85e-12 Bipolar disorder; CESC cis rs2243480 1.000 rs419603 chr7:65597341 C/T cg12463550 chr7:65579703 CRCP 0.73 5.68 0.33 3.5e-8 Diabetic kidney disease; CESC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg13770153 chr20:60521292 NA -0.5 -6.23 -0.36 1.79e-9 Body mass index; CESC cis rs10789491 1.000 rs35861275 chr1:47171909 A/C cg15501359 chr1:47185051 KIAA0494 -0.75 -7.8 -0.43 1.45e-13 Response to hepatitis C treatment; CESC cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs10927875 0.691 rs1048302 chr1:16340879 T/G cg21214613 chr1:16344536 HSPB7 0.38 5.6 0.33 5.35e-8 Dilated cardiomyopathy; CESC cis rs2073300 0.609 rs6137950 chr20:23418722 T/A cg12062639 chr20:23401060 NAPB 1.04 8.1 0.45 1.97e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg08968635 chr6:28129556 ZNF389 0.41 5.28 0.31 2.68e-7 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08193322 chr2:74730586 LOC151534;LBX2 0.53 6.27 0.36 1.43e-9 Gut microbiome composition (summer); CESC trans rs1814175 0.616 rs4881723 chr11:49788566 G/T cg03929089 chr4:120376271 NA -0.89 -13.67 -0.64 1.51e-32 Height; CESC cis rs5758659 0.657 rs5758587 chr22:42517636 C/G cg19513890 chr22:42538836 CYP2D7P1 0.36 5.37 0.31 1.74e-7 Cognitive function; CESC cis rs11792861 0.962 rs3829084 chr9:111801724 C/G cg13535736 chr9:111863775 C9orf5 0.5 6.7 0.38 1.28e-10 Menarche (age at onset); CESC cis rs2236918 0.687 rs1776136 chr1:242026845 G/A cg17736920 chr1:242011382 EXO1 0.56 7.18 0.4 6.97e-12 Menopause (age at onset); CESC cis rs854765 0.618 rs8066982 chr17:17851377 T/C cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC cis rs6540556 0.723 rs10863785 chr1:209908876 C/T cg05527609 chr1:210001259 C1orf107 0.6 6.93 0.39 3.2e-11 Red blood cell count; CESC cis rs34779708 0.931 rs2244100 chr10:35323636 G/A cg03585969 chr10:35415529 CREM -0.72 -9.78 -0.51 1.74e-19 Inflammatory bowel disease;Crohn's disease; CESC cis rs7833986 0.501 rs2719261 chr8:56941982 C/G cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.24 0.41 4.87e-12 Height; CESC cis rs7267979 1.000 rs6050630 chr20:25430745 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 3e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg00033643 chr7:134001901 SLC35B4 0.41 5.13 0.3 5.54e-7 Mean platelet volume; CESC cis rs2439831 0.850 rs11856795 chr15:44160582 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.43 0.42 1.45e-12 Lung cancer in ever smokers; CESC cis rs2072499 0.966 rs2853641 chr1:156181770 A/G cg24450063 chr1:156163899 SLC25A44 0.97 19.4 0.77 9e-53 Testicular germ cell tumor; CESC cis rs4953076 0.573 rs6544746 chr2:44407985 C/T cg04920474 chr2:44395004 PPM1B 0.49 6.22 0.36 1.92e-9 Height; CESC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.49 -6.61 -0.38 2.13e-10 Personality dimensions; CESC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg12963246 chr6:28129442 ZNF389 0.53 6.91 0.39 3.61e-11 Parkinson's disease; CESC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg08859206 chr1:53392774 SCP2 -0.68 -10.01 -0.52 3.33e-20 Monocyte count; CESC trans rs9929218 1.000 rs13334471 chr16:68800452 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.44 -0.46 2.13e-15 Colorectal cancer; CESC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.02 0.4 1.82e-11 Bipolar disorder; CESC cis rs8078723 0.738 rs3816472 chr17:38142677 A/C cg17467752 chr17:38218738 THRA -0.56 -8.21 -0.45 9.56e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC trans rs17685 0.672 rs10952841 chr7:75778626 A/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.42 0.61 3.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs6580649 0.941 rs7971668 chr12:48469696 T/C cg24011408 chr12:48396354 COL2A1 -0.4 -5.04 -0.3 8.67e-7 Lung cancer; CESC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg03452623 chr4:187889614 NA 0.86 15.16 0.68 8.45e-38 Lobe attachment (rater-scored or self-reported); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg02099313 chr1:231114956 TTC13;ARV1 0.48 6.21 0.36 2.09e-9 Tetralogy of Fallot; CESC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg22903657 chr4:1355424 KIAA1530 -0.37 -5.14 -0.3 5.34e-7 Obesity-related traits; CESC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs80130819 0.748 rs2732487 chr12:48686741 T/C cg05342945 chr12:48394962 COL2A1 -0.48 -5.23 -0.31 3.4e-7 Prostate cancer; CESC cis rs11098499 0.954 rs4345162 chr4:120312959 G/A cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.54 5.07 0.3 7.35e-7 Lung cancer in ever smokers; CESC cis rs8062405 0.573 rs11645306 chr16:28983936 G/C cg08761264 chr16:28874980 SH2B1 0.49 5.81 0.34 1.83e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg17221315 chr6:27791827 HIST1H4J 0.45 5.86 0.34 1.39e-8 Parkinson's disease; CESC cis rs12451471 0.620 rs11150846 chr17:78098520 C/T cg24585782 chr17:78113791 EIF4A3 -0.59 -8.04 -0.44 3.08e-14 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC trans rs4843747 0.671 rs74729706 chr16:88104159 C/T cg26811252 chr16:29126840 RRN3P2 0.68 9.51 0.5 1.23e-18 Menopause (age at onset); CESC cis rs6088580 0.634 rs6088508 chr20:33060081 A/G cg06115741 chr20:33292138 TP53INP2 0.48 6.11 0.35 3.58e-9 Glomerular filtration rate (creatinine); CESC trans rs61931739 0.929 rs1490110 chr12:34091605 A/G cg26384229 chr12:38710491 ALG10B -0.49 -6.9 -0.39 3.86e-11 Morning vs. evening chronotype; CESC cis rs80130819 0.515 rs1793915 chr12:48386577 G/T cg05342945 chr12:48394962 COL2A1 -0.51 -6.1 -0.35 3.71e-9 Prostate cancer; CESC cis rs989128 0.572 rs6504674 chr17:48630814 T/C cg24438145 chr17:48624694 SPATA20 0.45 5.31 0.31 2.36e-7 Type 2 diabetes; CESC cis rs7772486 0.875 rs9390377 chr6:146386932 G/A cg23711669 chr6:146136114 FBXO30 0.88 13.22 0.63 5.33e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg13175981 chr1:150552382 MCL1 0.72 10.69 0.55 2.04e-22 Tonsillectomy; CESC cis rs34779708 0.733 rs7070778 chr10:35541688 T/C cg04310649 chr10:35416472 CREM -0.47 -5.39 -0.31 1.59e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs9814567 0.896 rs6763188 chr3:134349995 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.42 5.67 0.33 3.77e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg23172400 chr8:95962367 TP53INP1 -0.45 -9.25 -0.49 8.02e-18 Type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24848437 chr7:2645542 IQCE 0.47 6.32 0.36 1.1e-9 Ulcerative colitis; CESC cis rs2479106 0.963 rs7850520 chr9:126509806 C/T cg16191174 chr9:126692580 DENND1A -0.48 -6.6 -0.38 2.22e-10 Polycystic ovary syndrome; CESC cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg22834771 chr12:69754056 YEATS4 -0.48 -6.47 -0.37 4.61e-10 Blood protein levels; CESC cis rs17253792 0.822 rs79618862 chr14:56093971 C/T cg01858014 chr14:56050164 KTN1 -0.83 -7.03 -0.4 1.7e-11 Putamen volume; CESC cis rs2295499 0.782 rs111559317 chr4:2719058 A/G cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.29 -0.31 2.57e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs2573652 0.722 rs11636084 chr15:100543394 A/G cg00587665 chr15:100533223 ADAMTS17 -0.4 -6.68 -0.38 1.4e-10 Height; CESC cis rs7247513 0.856 rs2162863 chr19:12699777 G/T cg01871581 chr19:12707946 ZNF490 -0.88 -15.42 -0.69 9.87e-39 Bipolar disorder; CESC cis rs6570726 0.967 rs7772286 chr6:145930423 A/T cg05347473 chr6:146136440 FBXO30 -0.45 -5.81 -0.34 1.82e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs17539620 0.624 rs111868524 chr6:154839960 G/C cg20019720 chr6:154832845 CNKSR3 0.44 5.57 0.32 6.24e-8 Lipoprotein (a) levels; CESC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg11663144 chr21:46675770 NA -0.5 -7.02 -0.4 1.9e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9584850 0.834 rs17574378 chr13:99116384 T/C cg20750642 chr13:99100586 FARP1 -0.37 -5.7 -0.33 3.16e-8 Neuroticism; CESC cis rs11098499 0.775 rs10021601 chr4:120282563 G/A cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs17209837 0.573 rs45537841 chr7:87110640 C/T cg00919237 chr7:87102261 ABCB4 -0.49 -6.46 -0.37 5.07e-10 Gallbladder cancer; CESC cis rs926392 0.640 rs4616534 chr20:37693564 G/A cg16355469 chr20:37678765 NA 0.56 6.35 0.36 9.32e-10 Dialysis-related mortality; CESC trans rs3780486 0.846 rs12554995 chr9:33132044 A/G cg04842962 chr6:43655489 MRPS18A 1.01 19.64 0.77 1.24e-53 IgG glycosylation; CESC cis rs10752881 0.740 rs1889307 chr1:183049389 T/A ch.1.3577855R chr1:183094577 LAMC1 0.86 13.21 0.63 6.06e-31 Colorectal cancer; CESC cis rs3820068 0.603 rs927207 chr1:15990552 A/G cg16988262 chr1:15930761 NA 0.35 5.67 0.33 3.81e-8 Systolic blood pressure; CESC cis rs4979906 1.000 rs2395494 chr10:79458340 C/T cg07817648 chr10:79422355 NA -0.58 -6.78 -0.38 7.85e-11 Mortality in heart failure; CESC cis rs2832191 0.791 rs2832196 chr21:30497412 G/A cg24692254 chr21:30365293 RNF160 -0.79 -12.11 -0.6 3.71e-27 Dental caries; CESC cis rs5758659 0.652 rs133327 chr22:42407689 T/C cg15557168 chr22:42548783 NA -0.42 -6.27 -0.36 1.48e-9 Cognitive function; CESC cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg22875332 chr1:76189707 ACADM 0.7 8.81 0.48 1.73e-16 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg24250549 chr1:154909240 PMVK 0.74 11.09 0.56 1.01e-23 Prostate cancer; CESC cis rs67311347 0.713 rs73073505 chr3:40310693 C/T cg09455208 chr3:40491958 NA 0.44 7.01 0.4 1.99e-11 Renal cell carcinoma; CESC cis rs7520050 0.808 rs11211196 chr1:46282296 A/T cg03146154 chr1:46216737 IPP -0.47 -6.19 -0.36 2.34e-9 Red blood cell count;Reticulocyte count; CESC cis rs875971 0.564 rs313804 chr7:65514622 A/G cg12463550 chr7:65579703 CRCP 0.59 7.47 0.42 1.16e-12 Aortic root size; CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg19592336 chr6:28129416 ZNF389 0.63 8.71 0.47 3.29e-16 Depression; CESC cis rs2838344 0.776 rs2298561 chr21:45085234 A/G cg04455712 chr21:45112962 RRP1B 0.5 7.75 0.43 2.03e-13 Coronary artery disease; CESC cis rs155076 0.711 rs4769158 chr13:21881975 T/C cg06138931 chr13:21896616 NA 0.51 5.27 0.31 2.8e-7 White matter hyperintensity burden; CESC cis rs7829975 0.514 rs2979151 chr8:8258019 A/G cg15556689 chr8:8085844 FLJ10661 -0.53 -6.88 -0.39 4.21e-11 Mood instability; CESC cis rs644799 1.000 rs473148 chr11:95628606 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.47 5.62 0.33 4.8e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6701037 0.681 rs1057239 chr1:175130204 G/A cg00321850 chr1:175162397 KIAA0040 -0.43 -6.2 -0.36 2.1e-9 Alcohol dependence; CESC cis rs7903847 0.667 rs10882931 chr10:99165794 C/A cg20016023 chr10:99160130 RRP12 -0.3 -5.12 -0.3 5.91e-7 Granulocyte percentage of myeloid white cells; CESC cis rs738322 0.718 rs3761445 chr22:38595411 G/A cg25457927 chr22:38595422 NA 0.36 6.83 0.39 5.91e-11 Cutaneous nevi; CESC cis rs116095464 0.558 rs10462755 chr5:246748 T/C cg22857025 chr5:266934 NA -1.28 -18.26 -0.75 8.94e-49 Breast cancer; CESC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.04 -0.44 3e-14 Personality dimensions; CESC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg21984481 chr17:79567631 NPLOC4 -0.35 -5.41 -0.32 1.43e-7 Eye color traits; CESC cis rs7236492 0.688 rs7241538 chr18:77191247 C/T cg15644404 chr18:77186268 NFATC1 -0.69 -5.3 -0.31 2.39e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs16910800 0.731 rs1871953 chr11:23192677 G/A cg20040320 chr11:23191996 NA -0.7 -7.13 -0.4 9.41e-12 Cancer; CESC cis rs11122272 0.766 rs2808614 chr1:231550168 A/G cg06096015 chr1:231504339 EGLN1 -0.41 -5.78 -0.33 2.13e-8 Hemoglobin concentration; CESC cis rs2637266 1.000 rs2894339 chr10:78354104 G/A cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg02038168 chr22:39784481 NA -0.63 -8.12 -0.45 1.71e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19754013 chr1:156252628 SMG5;TMEM79 0.57 6.04 0.35 5.06e-9 Gut microbiome composition (summer); CESC cis rs708547 0.647 rs1718831 chr4:57886946 T/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -5.52 -0.32 8.06e-8 Response to bleomycin (chromatid breaks); CESC cis rs7071206 0.947 rs11002226 chr10:79399656 T/A cg23888215 chr10:79422304 NA -0.53 -5.64 -0.33 4.4e-8 Bone mineral density; CESC cis rs14403 0.602 rs2994330 chr1:243647208 G/T cg21452805 chr1:244014465 NA 0.62 6.47 0.37 4.7e-10 Schizophrenia; CESC cis rs36051895 0.632 rs10974983 chr9:5149657 G/T cg02405213 chr9:5042618 JAK2 -0.53 -6.41 -0.37 6.47e-10 Pediatric autoimmune diseases; CESC cis rs7223966 1.000 rs6504168 chr17:61697469 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 6.68 0.38 1.41e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg24562669 chr7:97807699 LMTK2 0.48 6.92 0.39 3.3e-11 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26828057 chr1:38259483 MANEAL 0.57 6.01 0.35 6.01e-9 Gut microbiome composition (summer); CESC cis rs7267979 0.933 rs1130694 chr20:25276297 G/A cg08601574 chr20:25228251 PYGB 0.38 5.45 0.32 1.16e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 8.16 0.45 1.36e-14 Bipolar disorder; CESC cis rs62064224 0.714 rs4794917 chr17:30636146 C/G cg18200150 chr17:30822561 MYO1D 0.38 5.14 0.3 5.46e-7 Schizophrenia; CESC cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg22800045 chr5:56110881 MAP3K1 -0.61 -7.83 -0.43 1.21e-13 Initial pursuit acceleration; CESC cis rs2625529 0.730 rs7403191 chr15:72160964 C/T cg16672083 chr15:72433130 SENP8 -0.44 -6.44 -0.37 5.69e-10 Red blood cell count; CESC cis rs10791097 0.703 rs11222360 chr11:130730871 C/T cg12179176 chr11:130786555 SNX19 0.55 8.15 0.45 1.41e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs796364 1.000 rs281794 chr2:200846666 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.84 8.14 0.45 1.53e-14 Schizophrenia; CESC cis rs9640161 0.789 rs36035506 chr7:150057843 C/T cg10018233 chr7:150070692 REPIN1 0.39 5.59 0.32 5.7e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs7615952 0.673 rs7632557 chr3:125634881 G/C cg05084668 chr3:125655381 ALG1L -0.49 -5.46 -0.32 1.09e-7 Blood pressure (smoking interaction); CESC cis rs11718455 0.960 rs1852036 chr3:44003862 C/T cg08738300 chr3:44038990 NA 0.45 5.98 0.35 7e-9 Coronary artery disease; CESC cis rs9443645 0.527 rs9352663 chr6:79558164 T/C cg05283184 chr6:79620031 NA -0.37 -5.32 -0.31 2.26e-7 Intelligence (multi-trait analysis); CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg07157834 chr1:205819609 PM20D1 0.82 13.35 0.63 1.97e-31 Menarche (age at onset); CESC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg14983838 chr19:29218262 NA 0.5 6.16 0.35 2.67e-9 Methadone dose in opioid dependence; CESC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -7.03 -0.4 1.8e-11 Extrinsic epigenetic age acceleration; CESC cis rs7103648 0.695 rs10838726 chr11:47568344 C/G cg20307385 chr11:47447363 PSMC3 0.83 12.3 0.6 8.59e-28 Diastolic blood pressure;Systolic blood pressure; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg14932796 chr17:55038330 COIL 0.47 6.65 0.38 1.63e-10 Systemic lupus erythematosus; CESC cis rs3820928 0.839 rs13413292 chr2:227893747 G/C cg11843606 chr2:227700838 RHBDD1 -0.48 -6.38 -0.36 7.78e-10 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12612807 chr7:1522949 INTS1 -0.53 -6.1 -0.35 3.66e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13883366 chr10:29747149 SVIL 0.48 6.05 0.35 4.92e-9 Gut microbiome composition (summer); CESC cis rs9911578 0.835 rs1990008 chr17:56459408 C/G cg25039879 chr17:56429692 SUPT4H1 -0.4 -5.23 -0.31 3.39e-7 Intelligence (multi-trait analysis); CESC cis rs6430585 0.527 rs961360 chr2:136393658 A/G cg07169764 chr2:136633963 MCM6 1.01 11.6 0.58 1.92e-25 Corneal structure; CESC cis rs5758659 0.622 rs129856 chr22:42399396 C/G cg04733989 chr22:42467013 NAGA 0.43 5.72 0.33 2.81e-8 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05237023 chr16:75182837 ZFP1 0.71 7.85 0.43 1e-13 Gut microbiome composition (summer); CESC trans rs9951602 0.512 rs8089247 chr18:76651467 C/A cg02800362 chr5:177631904 HNRNPAB 0.66 8.64 0.47 5.41e-16 Obesity-related traits; CESC cis rs7560272 0.502 rs13013228 chr2:73925216 G/A cg20560298 chr2:73613845 ALMS1 0.45 6.19 0.36 2.22e-9 Schizophrenia; CESC cis rs34311866 0.808 rs3755958 chr4:963042 C/A cg07828340 chr4:882639 GAK 0.86 6.68 0.38 1.37e-10 Parkinson's disease; CESC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg18032046 chr6:28092343 ZSCAN16 -0.6 -6.84 -0.39 5.51e-11 Depression; CESC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg24829409 chr8:58192753 C8orf71 -0.77 -10.02 -0.52 2.95e-20 Developmental language disorder (linguistic errors); CESC cis rs9858542 0.953 rs9837027 chr3:49597013 C/T cg07274523 chr3:49395745 GPX1 0.65 8.34 0.46 3.99e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20784733 chr7:66205729 RABGEF1 0.62 7.36 0.41 2.29e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07798295 chr16:89715839 CHMP1A -0.58 -6.62 -0.38 1.96e-10 Gut microbiome composition (summer); CESC cis rs4077515 0.874 rs35670379 chr9:139270606 T/C cg14169450 chr9:139327907 INPP5E 0.42 6.02 0.35 5.73e-9 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1443512 0.812 rs1975470 chr12:54336841 G/A cg17410650 chr12:54324560 NA -0.48 -8.07 -0.44 2.41e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs9584850 1.000 rs9584850 chr13:99101426 G/C cg22223119 chr13:99095684 FARP1 -0.36 -5.23 -0.31 3.41e-7 Neuroticism; CESC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg09699651 chr6:150184138 LRP11 0.51 6.47 0.37 4.64e-10 Lung cancer; CESC cis rs722599 0.639 rs12882676 chr14:75272433 A/G cg11812906 chr14:75593930 NEK9 0.41 5.04 0.3 8.64e-7 IgG glycosylation; CESC cis rs17125944 0.505 rs2295826 chr14:53174923 C/T cg00686598 chr14:53173677 PSMC6 -1.29 -11.5 -0.58 4.39e-25 Alzheimer's disease (late onset); CESC cis rs62005083 0.541 rs61059815 chr14:74536465 A/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.55 5.65 0.33 4.03e-8 Mean corpuscular volume; CESC cis rs6142102 0.625 rs1883707 chr20:32552587 A/G cg08999081 chr20:33150536 PIGU -0.34 -5.25 -0.31 3.07e-7 Skin pigmentation; CESC cis rs7580658 0.963 rs6732279 chr2:128089540 G/T cg10021288 chr2:128175891 PROC -0.41 -6.46 -0.37 5.07e-10 Protein C levels; CESC cis rs6987853 0.688 rs2923433 chr8:42418723 T/C cg09913449 chr8:42400586 C8orf40 0.44 7.24 0.41 4.9e-12 Mean corpuscular hemoglobin concentration; CESC cis rs7589342 0.628 rs35622044 chr2:106404095 G/A cg16077055 chr2:106428750 NCK2 0.53 6.82 0.39 6.32e-11 Addiction; CESC cis rs11828289 0.599 rs75341566 chr11:23186941 C/A cg20040320 chr11:23191996 NA -0.68 -5.87 -0.34 1.31e-8 Cancer; CESC cis rs708547 0.957 rs781667 chr4:57798469 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.7 7.87 0.44 8.9e-14 Response to bleomycin (chromatid breaks); CESC cis rs9488822 0.676 rs1556857 chr6:116325559 T/C cg15226275 chr6:116381976 FRK 0.25 6.22 0.36 1.94e-9 Cholesterol, total;LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04090599 chr15:65281881 SPG21 0.54 6.19 0.36 2.29e-9 Gut microbiome composition (summer); CESC cis rs2710642 0.678 rs11125946 chr2:63298150 C/T cg17519650 chr2:63277830 OTX1 -0.63 -7.69 -0.43 2.93e-13 LDL cholesterol levels;LDL cholesterol; CESC cis rs6665290 0.669 rs12406714 chr1:227177061 T/C cg10327440 chr1:227177885 CDC42BPA -1.12 -24.44 -0.83 7.56e-70 Myeloid white cell count; CESC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg03188948 chr7:1209495 NA 0.73 7.17 0.4 7.66e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2997447 0.761 rs61776618 chr1:26456709 A/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.59 5.16 0.3 4.76e-7 QRS complex (12-leadsum); CESC trans rs4295623 0.553 rs11250163 chr8:11596437 G/T cg15556689 chr8:8085844 FLJ10661 0.52 6.03 0.35 5.41e-9 Morning vs. evening chronotype; CESC cis rs2832191 0.692 rs2254872 chr21:30414724 C/T cg24692254 chr21:30365293 RNF160 1.02 18.52 0.75 1.02e-49 Dental caries; CESC cis rs2404602 0.647 rs12440511 chr15:76993135 A/G cg06336613 chr15:77223807 RCN2 0.41 5.15 0.3 5.04e-7 Blood metabolite levels; CESC cis rs7809950 1.000 rs2520277 chr7:107130234 C/T cg23024343 chr7:107201750 COG5 -0.42 -5.86 -0.34 1.37e-8 Coronary artery disease; CESC cis rs4718428 0.705 rs4717328 chr7:66352665 T/C cg18252515 chr7:66147081 NA -0.46 -5.1 -0.3 6.48e-7 Corneal structure; CESC cis rs6502050 0.805 rs7406137 chr17:80084465 T/C cg23985595 chr17:80112537 CCDC57 0.4 6.25 0.36 1.66e-9 Life satisfaction; CESC cis rs6963495 0.818 rs73190184 chr7:105163736 C/T cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs35110281 0.501 rs162381 chr21:44920915 A/G cg01579765 chr21:45077557 HSF2BP 0.4 6.35 0.36 9.35e-10 Mean corpuscular volume; CESC cis rs1620921 0.505 rs4708882 chr6:161203182 C/T cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs7843479 0.601 rs727693 chr8:21850116 A/G cg17168535 chr8:21777572 XPO7 0.72 11.46 0.58 5.69e-25 Mean corpuscular volume; CESC cis rs9929218 0.539 rs1125557 chr16:68809599 G/A cg02972257 chr16:68554789 NA -0.42 -5.25 -0.31 3.17e-7 Colorectal cancer; CESC cis rs35079168 0.923 rs12115573 chr9:137288782 G/A cg13941235 chr9:137270186 RXRA -0.31 -5.51 -0.32 8.59e-8 Intelligence; CESC cis rs72781680 1.000 rs17763442 chr2:24255991 C/T cg08917208 chr2:24149416 ATAD2B 1.07 8.78 0.47 2.02e-16 Lymphocyte counts; CESC cis rs1395 0.778 rs4665959 chr2:27443256 C/T cg22903471 chr2:27725779 GCKR -0.42 -5.13 -0.3 5.57e-7 Blood metabolite levels; CESC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg24675658 chr1:53192096 ZYG11B -0.68 -9.65 -0.51 4.36e-19 Monocyte count; CESC cis rs11969893 0.850 rs3734351 chr6:101307131 C/T cg12253828 chr6:101329408 ASCC3 1.13 9.61 0.51 5.96e-19 Economic and political preferences (immigration/crime); CESC cis rs7666738 0.830 rs6532701 chr4:98745134 C/T cg05340658 chr4:99064831 C4orf37 0.76 11.16 0.57 5.63e-24 Colonoscopy-negative controls vs population controls; CESC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg11247378 chr22:39784982 NA -0.67 -9.75 -0.51 2.18e-19 Intelligence (multi-trait analysis); CESC trans rs2823962 0.759 rs2211987 chr21:18016656 T/C cg06419850 chr17:4688683 VMO1 -0.42 -6.13 -0.35 3.23e-9 Amyotrophic lateral sclerosis; CESC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg20790798 chr5:1857306 NA -0.4 -5.5 -0.32 9.07e-8 Cardiovascular disease risk factors; CESC cis rs10504073 0.647 rs10957357 chr8:49988587 C/A cg00325661 chr8:49890786 NA 0.53 7.81 0.43 1.32e-13 Blood metabolite ratios; CESC cis rs3820928 0.900 rs6754155 chr2:227784961 A/G cg05526886 chr2:227700861 RHBDD1 -0.46 -5.89 -0.34 1.16e-8 Pulmonary function; CESC cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg08027265 chr7:2291960 NA -0.43 -6.62 -0.38 2.02e-10 Schizophrenia; CESC cis rs11690935 0.959 rs13419987 chr2:172623914 T/C cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.95 -0.68 4.66e-37 Schizophrenia; CESC trans rs208520 0.779 rs208451 chr6:66906155 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.84 -9.54 -0.51 9.64e-19 Exhaled nitric oxide output; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20376421 chr12:56546193 MYL6B -0.44 -6.32 -0.36 1.08e-9 Fibrinogen levels; CESC cis rs2108622 0.727 rs2158511 chr19:15986647 C/T cg13772218 chr19:15982569 NA 0.3 5.91 0.34 1.07e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.89 9.97 0.52 4.36e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2288073 0.801 rs6757275 chr2:24375230 A/G cg06627628 chr2:24431161 ITSN2 -0.71 -9.06 -0.49 2.87e-17 Venous thromboembolism (SNP x SNP interaction); CESC cis rs1707322 0.827 rs6694302 chr1:46245645 A/T cg05343316 chr1:45956843 TESK2 0.47 5.67 0.33 3.68e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6460942 0.597 rs13227809 chr7:12525557 G/A cg06484146 chr7:12443880 VWDE -0.71 -7.69 -0.43 2.88e-13 Coronary artery disease; CESC cis rs1348850 0.837 rs4243388 chr2:178284604 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.86 12.77 0.62 1.97e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg11644478 chr21:40555479 PSMG1 0.95 14.26 0.66 1.25e-34 Cognitive function; CESC cis rs4629710 0.545 rs11755717 chr6:131547028 A/T cg20988616 chr6:131958144 ENPP3 0.4 5.09 0.3 6.7e-7 Multiple myeloma (IgH translocation); CESC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg19346786 chr7:2764209 NA 0.37 5.36 0.31 1.81e-7 Height; CESC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC cis rs8114671 0.562 rs725521 chr20:33516071 T/C cg24642439 chr20:33292090 TP53INP2 0.43 5.19 0.3 4.19e-7 Height; CESC cis rs12413816 0.963 rs10796116 chr10:13762786 C/T cg16485048 chr10:13749193 FRMD4A -0.53 -7.57 -0.42 6.25e-13 Red cell distribution width; CESC cis rs2439831 0.850 rs28504496 chr15:44016883 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.68 6.42 0.37 6.21e-10 Lung cancer in ever smokers; CESC cis rs9796 0.840 rs1009913 chr15:41331050 C/T cg18705301 chr15:41695430 NDUFAF1 0.4 6.02 0.35 5.74e-9 Menopause (age at onset); CESC cis rs4974559 0.739 rs6845586 chr4:1323070 G/A cg02980000 chr4:1222292 CTBP1 0.81 7.22 0.41 5.48e-12 Systolic blood pressure; CESC cis rs6088580 0.570 rs6058057 chr20:33065283 G/A cg08999081 chr20:33150536 PIGU 0.66 11.57 0.58 2.49e-25 Glomerular filtration rate (creatinine); CESC cis rs13394619 0.935 rs6746291 chr2:11728381 T/C cg07314298 chr2:11723111 GREB1 -0.47 -6.71 -0.38 1.19e-10 Endometriosis; CESC cis rs1348850 0.567 rs880899 chr2:178532416 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.25 0.41 4.54e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10870270 0.956 rs4880405 chr10:133787021 G/A cg17892150 chr10:133769511 PPP2R2D -0.84 -11.79 -0.59 4.4e-26 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg12698349 chr2:225449008 CUL3 0.62 8.7 0.47 3.49e-16 IgE levels in asthmatics (D.p. specific); CESC cis rs9300255 0.679 rs4759409 chr12:123719585 G/C cg19016782 chr12:123741754 C12orf65 -0.48 -6.7 -0.38 1.22e-10 Neutrophil percentage of white cells; CESC cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg07697082 chr8:82753677 SNX16 0.38 5.21 0.31 3.72e-7 Diastolic blood pressure; CESC cis rs9309473 0.687 rs6748040 chr2:73609928 A/G cg20560298 chr2:73613845 ALMS1 0.46 6.42 0.37 6.16e-10 Metabolite levels; CESC cis rs7660520 0.524 rs4862100 chr4:183732709 G/T cg12524338 chr4:183729343 NA 0.54 5.21 0.3 3.86e-7 Pediatric autoimmune diseases; CESC cis rs7296418 0.599 rs2277343 chr12:123794450 A/T cg05973401 chr12:123451056 ABCB9 0.43 5.45 0.32 1.14e-7 Platelet count; CESC cis rs7044106 0.762 rs1530370 chr9:123424552 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.17 0.45 1.32e-14 Hip circumference adjusted for BMI; CESC cis rs9640161 0.789 rs6964110 chr7:150041836 A/C cg13722127 chr7:150037890 RARRES2 0.36 5.24 0.31 3.27e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg12963246 chr6:28129442 ZNF389 0.41 6.0 0.35 6.29e-9 Cardiac Troponin-T levels; CESC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg22800045 chr5:56110881 MAP3K1 -0.52 -6.26 -0.36 1.53e-9 Coronary artery disease; CESC cis rs7089973 0.966 rs36089581 chr10:116623059 G/C cg23260525 chr10:116636907 FAM160B1 0.38 6.1 0.35 3.76e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs116095464 0.558 rs10057492 chr5:239503 T/C cg22496380 chr5:211416 CCDC127 -0.75 -8.78 -0.47 2.13e-16 Breast cancer; CESC cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg08847533 chr14:75593920 NEK9 -0.9 -15.59 -0.69 2.49e-39 Height; CESC cis rs9902453 1.000 rs59274738 chr17:28437635 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 7.96 0.44 5.17e-14 Coffee consumption (cups per day); CESC cis rs515186 1 rs515186 chr6:36397492 T/G cg07856975 chr6:36356162 ETV7 0.36 5.38 0.31 1.67e-7 Mean platelet volume; CESC cis rs2011503 1.000 rs4808968 chr19:19644402 C/T cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs2279817 0.818 rs34036216 chr1:17986046 C/T cg21791023 chr1:18019539 ARHGEF10L -0.66 -8.02 -0.44 3.39e-14 Neuroticism; CESC trans rs5769765 0.862 rs56377703 chr22:50306940 C/T cg09872104 chr7:134855509 C7orf49 -0.55 -6.26 -0.36 1.55e-9 Schizophrenia; CESC cis rs6598955 0.670 rs6663950 chr1:26560131 T/C cg00852783 chr1:26633632 UBXN11 0.42 6.17 0.35 2.55e-9 Obesity-related traits; CESC cis rs4699052 0.963 rs11943325 chr4:104178393 T/C cg16532752 chr4:104119610 CENPE -0.44 -6.16 -0.35 2.65e-9 Testicular germ cell tumor; CESC cis rs9393777 0.623 rs9358947 chr6:26479000 G/A cg12826209 chr6:26865740 GUSBL1 0.65 6.85 0.39 5.16e-11 Intelligence (multi-trait analysis); CESC cis rs4835473 0.932 rs6852502 chr4:144908327 A/T cg25736465 chr4:144833511 NA 0.43 6.47 0.37 4.59e-10 Immature fraction of reticulocytes; CESC cis rs1348850 0.526 rs935426 chr2:178369433 T/C cg22681709 chr2:178499509 PDE11A -0.5 -5.26 -0.31 2.97e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7107356 1 rs7107356 chr11:47676170 A/G cg20307385 chr11:47447363 PSMC3 0.68 9.81 0.52 1.42e-19 Neuroticism;Neuroticism (multi-trait analysis); CESC cis rs2447097 0.935 rs2447095 chr17:2293420 A/G cg27406664 chr17:2294951 MNT 0.4 6.75 0.38 9.07e-11 Autism spectrum disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22320231 chr17:28903436 LRRC37B2 -0.5 -6.48 -0.37 4.39e-10 Gut microbiome composition (summer); CESC cis rs820218 0.926 rs864234 chr17:73663313 C/A cg01592526 chr17:73663357 RECQL5;SAP30BP 0.43 5.53 0.32 7.51e-8 Rotator cuff tears; CESC cis rs72945132 0.882 rs72947012 chr11:70149472 G/A cg00319359 chr11:70116639 PPFIA1 0.82 7.48 0.42 1.07e-12 Coronary artery disease; CESC cis rs2860975 0.542 rs1926705 chr10:96818418 C/T cg09036531 chr10:96991505 NA -0.37 -5.3 -0.31 2.45e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg24060327 chr5:131705240 SLC22A5 -0.47 -6.09 -0.35 4.03e-9 Acylcarnitine levels; CESC cis rs6088590 0.707 rs67159833 chr20:33488079 T/C cg08999081 chr20:33150536 PIGU 0.58 8.23 0.45 8.75e-15 Coronary artery disease; CESC cis rs11030122 0.702 rs1452047 chr11:3991648 A/C cg18678763 chr11:4115507 RRM1 -0.49 -6.42 -0.37 6.34e-10 Mean platelet volume;Platelet distribution width; CESC cis rs477692 1.000 rs513736 chr10:131406489 C/T cg05714579 chr10:131428358 MGMT 0.48 6.57 0.37 2.71e-10 Response to temozolomide; CESC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.9 0.52 7.05e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs2108622 0.649 rs113055956 chr19:15977312 T/A cg13772218 chr19:15982569 NA 0.27 5.18 0.3 4.47e-7 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs1800795 0.901 rs2069833 chr7:22767664 C/T cg26061582 chr7:22766209 IL6 0.47 5.39 0.31 1.58e-7 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CESC cis rs2985684 0.740 rs2883438 chr14:50044392 T/C cg04989706 chr14:50066350 PPIL5 -0.46 -5.16 -0.3 4.92e-7 Carotid intima media thickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11662638 chr2:45878864 PRKCE 0.59 6.99 0.39 2.29e-11 Gut microbiome composition (summer); CESC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg09658497 chr7:2847517 GNA12 -0.43 -6.14 -0.35 3.07e-9 Height; CESC cis rs6087990 0.735 rs2065576 chr20:31389009 C/T cg13636640 chr20:31349939 DNMT3B 0.79 12.92 0.62 6.22e-30 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05014452 chr15:79603196 TMED3 -0.53 -6.31 -0.36 1.17e-9 Gut microbiome composition (summer); CESC trans rs1728785 1.000 rs1728780 chr16:68567642 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.43 0.42 1.5e-12 Ulcerative colitis; CESC cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg14416269 chr4:6271139 WFS1 0.47 7.74 0.43 2.05e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg25405998 chr7:65216604 CCT6P1 0.45 5.06 0.3 7.71e-7 Aortic root size; CESC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.49 -5.2 -0.3 4.06e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4722166 0.598 rs4722180 chr7:22805072 A/G cg05472934 chr7:22766657 IL6 0.42 5.71 0.33 2.99e-8 Lung cancer; CESC cis rs8014204 0.753 rs6574199 chr14:75356103 T/C cg26191576 chr14:75389716 RPS6KL1 0.35 5.03 0.3 9.15e-7 Caffeine consumption; CESC cis rs6088590 0.965 rs6119534 chr20:33441257 C/T cg08999081 chr20:33150536 PIGU 0.57 8.67 0.47 4.32e-16 Coronary artery disease; CESC cis rs909002 0.624 rs11590964 chr1:32146425 C/T cg13919466 chr1:32135498 COL16A1 -0.38 -6.23 -0.36 1.81e-9 Intelligence (multi-trait analysis); CESC cis rs853679 0.546 rs34371502 chr6:28081758 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 5.58 0.32 6.04e-8 Depression; CESC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg00310523 chr12:86230176 RASSF9 0.37 5.49 0.32 9.48e-8 Major depressive disorder; CESC cis rs9905704 0.918 rs302852 chr17:56685214 C/T cg12560992 chr17:57184187 TRIM37 0.59 6.98 0.39 2.34e-11 Testicular germ cell tumor; CESC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg11764359 chr7:65958608 NA 0.66 8.59 0.47 7.42e-16 Aortic root size; CESC cis rs10791323 0.581 rs2723608 chr11:133710149 A/G cg06766960 chr11:133703094 NA -0.41 -5.77 -0.33 2.24e-8 Childhood ear infection; CESC cis rs17384381 0.863 rs12140272 chr1:85789757 G/A cg16011679 chr1:85725395 C1orf52 0.67 6.96 0.39 2.64e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18864497 chr6:7313384 SSR1 0.59 6.35 0.36 9.1e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15876657 chr6:144416565 SF3B5 0.66 7.44 0.42 1.41e-12 Gut microbiome composition (summer); CESC cis rs853679 1.000 rs1778508 chr6:28229881 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL -0.68 -7.18 -0.4 7.04e-12 Depression; CESC cis rs193541 0.530 rs9327272 chr5:122073548 T/C cg19412675 chr5:122181750 SNX24 0.44 5.2 0.3 3.95e-7 Glucose homeostasis traits; CESC cis rs6456156 0.524 rs6932740 chr6:167466439 G/A cg07741184 chr6:167504864 NA 0.35 6.08 0.35 4.1e-9 Primary biliary cholangitis; CESC cis rs7918232 0.567 rs4749215 chr10:27312005 T/C cg14240646 chr10:27532245 ACBD5 -0.49 -5.35 -0.31 1.87e-7 Breast cancer; CESC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg20790798 chr5:1857306 NA -0.4 -5.35 -0.31 1.93e-7 Cardiovascular disease risk factors; CESC cis rs9902453 0.765 rs2127001 chr17:28098219 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.41 -0.54 1.71e-21 Coffee consumption (cups per day); CESC cis rs67311347 1.000 rs28536038 chr3:40496382 A/C cg09455208 chr3:40491958 NA 0.5 7.96 0.44 5.11e-14 Renal cell carcinoma; CESC cis rs12479064 0.724 rs112900993 chr2:99948805 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -7.8 -0.43 1.4e-13 Chronic sinus infection; CESC cis rs9399137 0.507 rs13196486 chr6:135283874 C/G cg24558204 chr6:135376177 HBS1L 0.7 9.64 0.51 4.87e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24594830 chr12:77459352 E2F7 -0.5 -6.51 -0.37 3.82e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12477438 0.501 rs6542868 chr2:99782848 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.62 0.61 6.6e-29 Chronic sinus infection; CESC cis rs7605827 0.930 rs6722963 chr2:15527105 C/T cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs1580019 0.587 rs7805311 chr7:32558302 A/G cg06627557 chr7:32535165 LSM5;AVL9 -1.04 -17.97 -0.74 9.08e-48 Cognitive ability; CESC cis rs8077577 0.895 rs11655588 chr17:18107451 C/T cg16794390 chr17:18148240 FLII -0.42 -5.73 -0.33 2.66e-8 Obesity-related traits; CESC cis rs1200821 0.529 rs2505707 chr10:37801254 T/C cg25427524 chr10:38739819 LOC399744 -0.44 -5.73 -0.33 2.73e-8 Hemostatic factors and hematological phenotypes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25096582 chr14:35183928 CFL2 -0.47 -6.43 -0.37 5.84e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg10792982 chr14:105748885 BRF1 0.42 5.81 0.34 1.75e-8 Mean platelet volume;Platelet distribution width; CESC cis rs17401966 1.000 rs12129035 chr1:10291166 G/A cg15208524 chr1:10270712 KIF1B 0.47 6.14 0.35 3.07e-9 Hepatocellular carcinoma; CESC cis rs6783573 0.535 rs6442006 chr3:46629382 C/G cg27371741 chr3:46619158 LRRC2;TDGF1 -0.35 -5.41 -0.32 1.41e-7 Cerebrospinal fluid biomarker levels; CESC cis rs4604732 0.631 rs12038793 chr1:247624262 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 -0.48 -6.09 -0.35 4.03e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg02725872 chr8:58115012 NA -0.44 -6.89 -0.39 4.12e-11 Developmental language disorder (linguistic errors); CESC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg04166393 chr7:2884313 GNA12 0.59 7.64 0.42 4.02e-13 Height; CESC cis rs7296418 0.630 rs11057238 chr12:123767971 C/A cg05973401 chr12:123451056 ABCB9 0.43 5.46 0.32 1.07e-7 Platelet count; CESC cis rs8040855 0.597 rs994989 chr15:85660716 G/C cg08123816 chr15:85640762 PDE8A -0.4 -5.72 -0.33 2.82e-8 Bulimia nervosa; CESC cis rs6500395 0.962 rs9938126 chr16:48572121 A/T cg04672837 chr16:48644449 N4BP1 0.44 5.29 0.31 2.57e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs67478160 0.643 rs4900594 chr14:104251006 C/T cg01849466 chr14:104193079 ZFYVE21 -0.5 -6.96 -0.39 2.72e-11 Schizophrenia; CESC cis rs9894429 0.690 rs12949956 chr17:79542813 C/T cg18240062 chr17:79603768 NPLOC4 -0.85 -12.34 -0.6 5.95e-28 Eye color traits; CESC cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs709400 0.930 rs10134399 chr14:104083457 G/A cg24130564 chr14:104152367 KLC1 -0.42 -5.12 -0.3 5.96e-7 Body mass index; CESC cis rs599083 0.530 rs640569 chr11:68184820 A/G cg01657329 chr11:68192670 LRP5 0.44 5.21 0.3 3.85e-7 Bone mineral density (spine); CESC cis rs17384381 0.859 rs12724823 chr1:85906385 G/T cg16011679 chr1:85725395 C1orf52 0.74 7.35 0.41 2.47e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.73 -10.3 -0.53 3.88e-21 Prudent dietary pattern; CESC cis rs6674176 0.561 rs4660263 chr1:44421433 A/C cg13606994 chr1:44402422 ARTN -0.37 -5.55 -0.32 6.85e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7647973 0.580 rs35218722 chr3:49275805 A/G cg06212747 chr3:49208901 KLHDC8B 0.71 10.86 0.55 5.86e-23 Menarche (age at onset); CESC cis rs11098499 0.731 rs6846966 chr4:120293208 A/G cg09307838 chr4:120376055 NA 0.86 11.82 0.59 3.43e-26 Corneal astigmatism; CESC cis rs17655565 0.581 rs74672767 chr12:52764049 C/A cg00777198 chr12:52828273 KRT75 0.35 5.07 0.3 7.59e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04588562 chr17:46756094 NA -0.41 -6.51 -0.37 3.76e-10 Gambling; CESC cis rs4268898 0.717 rs2543662 chr2:24443271 G/T cg06627628 chr2:24431161 ITSN2 0.85 10.38 0.54 2.07e-21 Asthma; CESC cis rs7103648 0.553 rs12803857 chr11:47890172 G/A cg20307385 chr11:47447363 PSMC3 0.8 10.73 0.55 1.57e-22 Diastolic blood pressure;Systolic blood pressure; CESC cis rs8027181 0.617 rs12438864 chr15:73095668 T/C cg25632853 chr15:73088954 NA 0.38 6.14 0.35 2.96e-9 Triglyceride levels; CESC cis rs7084402 0.902 rs1658484 chr10:60288543 G/A cg07615347 chr10:60278583 BICC1 0.59 9.2 0.49 1.13e-17 Refractive error; CESC cis rs703842 1.000 rs4646536 chr12:58157988 A/G cg00677455 chr12:58241039 CTDSP2 0.53 7.06 0.4 1.49e-11 Multiple sclerosis; CESC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg24642844 chr7:1081250 C7orf50 -0.76 -9.45 -0.5 1.94e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7923609 0.967 rs4454603 chr10:65012750 C/T cg01631684 chr10:65280961 REEP3 -0.44 -5.48 -0.32 9.99e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs2243480 1.000 rs7794661 chr7:65389730 T/C cg13147721 chr7:65941812 NA -0.85 -8.05 -0.44 2.87e-14 Diabetic kidney disease; CESC cis rs34172651 0.917 rs172066 chr16:24756449 C/T cg06028605 chr16:24865363 SLC5A11 0.35 5.4 0.31 1.46e-7 Intelligence (multi-trait analysis); CESC cis rs561341 1.000 rs546748 chr17:30324293 A/C cg23018236 chr17:30244563 NA -0.45 -5.49 -0.32 9.19e-8 Hip circumference adjusted for BMI; CESC cis rs644799 0.965 rs598876 chr11:95560853 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.27 0.66 1.19e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4654899 1.000 rs7521675 chr1:21424070 T/C cg05370193 chr1:21551575 ECE1 0.39 5.95 0.34 8.34e-9 Superior frontal gyrus grey matter volume; CESC cis rs6964587 0.655 rs6465351 chr7:91773213 T/C cg01689657 chr7:91764605 CYP51A1 0.26 5.1 0.3 6.44e-7 Breast cancer; CESC cis rs2034088 0.833 rs9748016 chr17:410451 G/T cg13332499 chr17:408570 NA 0.48 8.49 0.46 1.51e-15 Hip circumference adjusted for BMI; CESC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg08822215 chr16:89438651 ANKRD11 -0.35 -5.31 -0.31 2.31e-7 Multiple myeloma (IgH translocation); CESC cis rs253959 0.656 rs2063249 chr5:115415657 C/T cg23108291 chr5:115420582 COMMD10 0.4 5.05 0.3 8.37e-7 Bipolar disorder and schizophrenia; CESC cis rs6032067 0.777 rs34233258 chr20:43788265 G/A cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg03467027 chr4:99064603 C4orf37 0.44 5.55 0.32 6.79e-8 Colonoscopy-negative controls vs population controls; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg15324917 chr1:230992843 C1orf198 -0.46 -6.29 -0.36 1.31e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2637266 0.783 rs7914756 chr10:78476406 A/T cg18941641 chr10:78392320 NA -0.4 -7.53 -0.42 7.88e-13 Pulmonary function; CESC cis rs7267979 0.866 rs2424699 chr20:25257462 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 16.25 0.71 1.11e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs854765 0.583 rs12603148 chr17:17865257 C/T cg09796270 chr17:17721594 SREBF1 0.41 5.64 0.33 4.34e-8 Total body bone mineral density; CESC cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg11890956 chr21:40555474 PSMG1 -0.65 -9.22 -0.49 9.49e-18 Menarche (age at onset); CESC cis rs9911578 0.765 rs66954617 chr17:56999427 A/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.02 -0.4 1.89e-11 Intelligence (multi-trait analysis); CESC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg13206674 chr6:150067644 NUP43 0.41 5.74 0.33 2.64e-8 Lung cancer; CESC cis rs9513593 1.000 rs4772181 chr13:99860966 C/G cg21788972 chr13:99853209 UBAC2 0.65 7.38 0.41 2.04e-12 Psoriasis; CESC cis rs2011503 0.941 rs55762233 chr19:19367319 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.34 0.31 1.97e-7 Bipolar disorder; CESC trans rs9354308 0.933 rs1938068 chr6:66607807 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.66 7.45 0.42 1.33e-12 Metabolite levels; CESC trans rs1973993 0.567 rs2800431 chr1:97000998 C/T cg10631902 chr5:14652156 NA 0.49 7.24 0.41 4.93e-12 Weight; CESC cis rs7772486 0.686 rs2072911 chr6:146056801 G/A cg05347473 chr6:146136440 FBXO30 -0.51 -6.75 -0.38 9.36e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9811920 0.893 rs9814549 chr3:99892190 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -7.13 -0.4 9.26e-12 Axial length; CESC cis rs17826219 0.568 rs7213925 chr17:29121634 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Body mass index; CESC cis rs7927771 1.000 rs7927771 chr11:47781306 A/G cg05585544 chr11:47624801 NA -0.5 -7.88 -0.44 8.28e-14 Subjective well-being; CESC cis rs61931739 0.500 rs7298322 chr12:34445489 A/T cg23762105 chr12:34175262 ALG10 -0.4 -5.22 -0.31 3.7e-7 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13096541 chr6:138482936 KIAA1244 -0.42 -6.07 -0.35 4.5e-9 Gambling; CESC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg22535103 chr8:58192502 C8orf71 -0.77 -8.73 -0.47 2.82e-16 Developmental language disorder (linguistic errors); CESC cis rs7223966 1.000 rs9909992 chr17:61731931 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.72 0.38 1.12e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs13256369 0.708 rs11783670 chr8:8559394 G/A cg00074818 chr8:8560427 CLDN23 0.38 5.34 0.31 2.05e-7 Obesity-related traits; CESC cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg22875332 chr1:76189707 ACADM 0.63 6.32 0.36 1.11e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs35146811 0.806 rs1534310 chr7:99699169 A/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.47 5.8 0.34 1.91e-8 Coronary artery disease; CESC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg25767906 chr1:53392781 SCP2 -0.46 -6.03 -0.35 5.48e-9 Monocyte count; CESC cis rs367943 0.547 rs11241218 chr5:112958258 T/C cg12552261 chr5:112820674 MCC 0.43 5.24 0.31 3.26e-7 Type 2 diabetes; CESC cis rs9790314 0.521 rs1376122 chr3:161087857 A/G cg04691961 chr3:161091175 C3orf57 -0.37 -5.09 -0.3 6.66e-7 Morning vs. evening chronotype; CESC cis rs7772486 0.754 rs9497419 chr6:146142609 T/C cg05347473 chr6:146136440 FBXO30 0.54 6.96 0.39 2.63e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs3806843 0.966 rs12659129 chr5:140147248 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.37 -5.03 -0.3 9.19e-7 Depressive symptoms (multi-trait analysis); CESC cis rs4722166 0.564 rs1800797 chr7:22766221 A/G cg05265849 chr7:22767390 IL6 0.44 5.45 0.32 1.15e-7 Lung cancer; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 6.74 0.38 9.78e-11 Electroencephalogram traits; CESC cis rs10927875 0.691 rs1048261 chr1:16340951 A/T cg21214613 chr1:16344536 HSPB7 0.37 5.39 0.31 1.56e-7 Dilated cardiomyopathy; CESC cis rs6674176 0.561 rs7161 chr1:44438974 A/G cg23954153 chr1:44402353 ARTN 0.34 5.31 0.31 2.35e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs12042052 0.590 rs72752167 chr1:232922414 G/A cg06935979 chr1:232941706 KIAA1383 0.62 5.48 0.32 9.65e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs28489187 0.706 rs233062 chr1:85800385 T/G cg16011679 chr1:85725395 C1orf52 0.48 5.68 0.33 3.58e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs763121 0.815 rs9306328 chr22:39028913 C/T cg06544989 chr22:39130855 UNC84B 0.46 8.46 0.46 1.79e-15 Menopause (age at onset); CESC cis rs12142240 0.698 rs6429599 chr1:46827871 G/A cg00530320 chr1:46809349 NSUN4 0.6 8.01 0.44 3.75e-14 Menopause (age at onset); CESC cis rs739401 0.611 rs494427 chr11:3048140 A/G cg25174290 chr11:3078921 CARS 0.54 7.71 0.43 2.5e-13 Longevity; CESC cis rs4862750 0.872 rs7664463 chr4:187876686 A/C cg22105103 chr4:187893119 NA 0.43 6.19 0.36 2.23e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg22920501 chr2:26401640 FAM59B -0.65 -7.79 -0.43 1.53e-13 Gut microbiome composition (summer); CESC cis rs11122272 0.766 rs2790872 chr1:231540543 A/T cg06096015 chr1:231504339 EGLN1 0.41 5.72 0.33 2.89e-8 Hemoglobin concentration; CESC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg03806693 chr22:41940476 POLR3H 1.15 15.89 0.7 2.22e-40 Vitiligo; CESC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg04756594 chr16:24857601 SLC5A11 0.46 5.72 0.33 2.9e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2274273 1.000 rs6573006 chr14:55610432 T/C cg04306507 chr14:55594613 LGALS3 0.31 6.26 0.36 1.57e-9 Protein biomarker; CESC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg09323728 chr8:95962352 TP53INP1 -0.4 -8.68 -0.47 4.05e-16 Type 2 diabetes; CESC trans rs875971 0.638 rs6960778 chr7:66071597 C/T cg26939375 chr7:64535504 NA -0.64 -8.58 -0.47 7.92e-16 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15092395 chr3:33155457 CRTAP 0.63 7.5 0.42 9.48e-13 Gut microbiome composition (summer); CESC cis rs17345786 0.861 rs17402964 chr3:101067945 C/T cg12386194 chr3:101231763 SENP7 0.54 5.79 0.34 1.94e-8 Colonoscopy-negative controls vs population controls; CESC cis rs929354 0.713 rs3802130 chr7:156965237 A/G cg05182265 chr7:156933206 UBE3C -0.5 -7.3 -0.41 3.28e-12 Body mass index; CESC cis rs5758511 0.689 rs45441993 chr22:42471738 C/A cg00645731 chr22:42541494 CYP2D7P1 0.57 6.94 0.39 3.09e-11 Birth weight; CESC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 14.04 0.65 7.76e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11792861 0.816 rs11790105 chr9:111731785 T/C cg13535736 chr9:111863775 C9orf5 -0.47 -6.26 -0.36 1.53e-9 Menarche (age at onset); CESC trans rs12681287 0.547 rs13249177 chr8:87513034 A/G cg27317242 chr8:23145699 R3HCC1 -0.53 -6.31 -0.36 1.19e-9 Caudate activity during reward; CESC cis rs7818345 0.845 rs11782540 chr8:19268251 A/G cg11303988 chr8:19266685 CSGALNACT1 0.37 6.56 0.37 2.81e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs6963495 0.719 rs73190172 chr7:105161210 T/C cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg14703610 chr5:56206110 C5orf35 0.42 5.26 0.31 2.98e-7 Coronary artery disease; CESC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.51 0.46 1.28e-15 Intelligence (multi-trait analysis); CESC trans rs1557351 0.723 rs1942343 chr18:54720660 T/G cg11433624 chr6:7146702 RREB1 0.39 6.27 0.36 1.48e-9 Multiple sclerosis (age of onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26661436 chr5:141031071 FCHSD1 0.55 6.24 0.36 1.7e-9 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg04944784 chr2:26401820 FAM59B -0.66 -7.66 -0.43 3.61e-13 Gut microbiome composition (summer); CESC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg05564831 chr3:52568323 NT5DC2 0.46 6.78 0.38 7.62e-11 Bipolar disorder; CESC cis rs6032067 0.586 rs62208373 chr20:43764426 G/A cg10761708 chr20:43804764 PI3 0.54 5.97 0.34 7.62e-9 Blood protein levels; CESC cis rs317689 0.718 rs160827 chr12:69770147 G/A cg14784868 chr12:69753453 YEATS4 0.64 7.55 0.42 6.85e-13 Response to diuretic therapy; CESC cis rs3741404 0.609 rs651855 chr11:63870810 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 9.92 0.52 6.36e-20 Platelet count; CESC cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg15506890 chr2:3487001 NA -0.51 -6.65 -0.38 1.71e-10 Neurofibrillary tangles; CESC trans rs11720469 0.967 rs9874940 chr3:166471573 T/G cg03163944 chr19:37663716 ZNF585A -0.42 -6.05 -0.35 4.86e-9 Fast beta electroencephalogram; CESC cis rs7223966 1.000 rs8066719 chr17:61825764 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.7 0.38 1.26e-10 Hip circumference adjusted for BMI;Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16517021 chr16:11945358 RSL1D1 0.54 6.07 0.35 4.41e-9 Gut microbiome composition (summer); CESC cis rs13242816 0.881 rs17138706 chr7:116109019 A/G cg04696780 chr7:116139425 CAV2 -0.63 -5.71 -0.33 2.98e-8 P wave duration; CESC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg10691866 chr7:65817282 TPST1 -0.32 -5.27 -0.31 2.89e-7 Aortic root size; CESC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg11890956 chr21:40555474 PSMG1 1.12 18.28 0.75 7.69e-49 Cognitive function; CESC cis rs6546537 1.000 rs4852892 chr2:69866769 T/A cg10773587 chr2:69614142 GFPT1 -0.62 -7.57 -0.42 6.12e-13 Serum thyroid-stimulating hormone levels; CESC cis rs10876993 0.928 rs2640636 chr12:58077544 A/G cg18357645 chr12:58087776 OS9 0.63 10.52 0.54 7.21e-22 Celiac disease or Rheumatoid arthritis; CESC cis rs7917772 0.503 rs56219824 chr10:104302337 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -5.97 -0.34 7.47e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7208859 0.573 rs73267865 chr17:29064204 C/G cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg05368731 chr17:41323189 NBR1 0.78 10.61 0.55 3.74e-22 Menopause (age at onset); CESC cis rs763121 0.752 rs5757222 chr22:39060473 C/T cg21395723 chr22:39101663 GTPBP1 0.43 5.37 0.31 1.74e-7 Menopause (age at onset); CESC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.74e-9 Prudent dietary pattern; CESC cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg04414720 chr1:150670196 GOLPH3L -0.37 -5.18 -0.3 4.37e-7 Tonsillectomy; CESC cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg05347473 chr6:146136440 FBXO30 0.5 6.56 0.37 2.8e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg24818145 chr4:99064322 C4orf37 0.39 5.14 0.3 5.42e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg17724175 chr1:150552817 MCL1 0.44 7.24 0.41 4.8e-12 Tonsillectomy; CESC cis rs2820292 0.619 rs12119907 chr1:201828755 T/C cg11586189 chr1:201857591 SHISA4 -0.36 -5.86 -0.34 1.38e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs6866344 0.697 rs11748497 chr5:178130012 C/G cg10224037 chr5:178157518 ZNF354A 0.67 7.41 0.41 1.67e-12 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18122310 chr12:50236657 BCDIN3D 0.6 7.12 0.4 9.98e-12 Gut microbiome composition (summer); CESC cis rs1185460 0.934 rs1006195 chr11:118958869 A/C cg23280166 chr11:118938394 VPS11 -0.49 -6.72 -0.38 1.12e-10 Coronary artery disease; CESC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg14262678 chr6:151773367 RMND1;C6orf211 0.67 9.57 0.51 8.08e-19 Menarche (age at onset); CESC cis rs1008375 1.000 rs10939738 chr4:17604295 G/C cg16339924 chr4:17578868 LAP3 0.63 8.08 0.44 2.34e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7662987 0.540 rs2851278 chr4:100021253 G/C cg12011299 chr4:100065546 ADH4 0.6 6.48 0.37 4.4e-10 Smoking initiation; CESC cis rs12681288 0.823 rs2701907 chr8:1003292 A/G cg15309053 chr8:964076 NA 0.34 5.76 0.33 2.31e-8 Schizophrenia; CESC cis rs6964587 0.692 rs2158138 chr7:91700879 A/G cg17063962 chr7:91808500 NA 0.46 6.59 0.38 2.33e-10 Breast cancer; CESC trans rs2727020 0.729 rs4980439 chr11:49342246 G/C cg15704280 chr7:45808275 SEPT13 -0.88 -14.73 -0.67 2.76e-36 Coronary artery disease; CESC cis rs8060686 0.565 rs36046686 chr16:68122269 T/C cg26727032 chr16:67993705 SLC12A4 -0.54 -6.05 -0.35 4.92e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg02297831 chr4:17616191 MED28 0.5 6.07 0.35 4.52e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs698833 0.819 rs2340809 chr2:44536249 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.49 0.32 9.46e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7208859 0.623 rs28627615 chr17:29145817 G/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg06456125 chr7:65229604 NA -0.41 -5.39 -0.31 1.55e-7 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25794979 chr16:2732314 KCTD5 -0.47 -6.73 -0.38 1.04e-10 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05013942 chr17:36003336 DDX52 0.63 6.8 0.39 6.91e-11 Gut microbiome composition (summer); CESC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.47 -5.73 -0.33 2.74e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg06108461 chr20:60628389 TAF4 -0.92 -14.55 -0.67 1.22e-35 Body mass index; CESC cis rs796364 0.806 rs11684942 chr2:201009136 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -6.48 -0.37 4.47e-10 Schizophrenia; CESC cis rs847577 0.722 rs6951277 chr7:97711783 A/G cg21770322 chr7:97807741 LMTK2 0.64 10.58 0.55 4.59e-22 Breast cancer; CESC cis rs9457247 1.000 rs1794693 chr6:167405670 T/C cg07741184 chr6:167504864 NA 0.29 5.31 0.31 2.32e-7 Crohn's disease; CESC cis rs1048238 0.506 rs10927866 chr1:16175317 C/T cg21385522 chr1:16154831 NA 0.45 5.84 0.34 1.53e-8 Systolic blood pressure; CESC cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg22467129 chr15:76604101 ETFA -0.38 -5.81 -0.34 1.81e-8 Blood metabolite levels; CESC cis rs7223966 1.000 rs6504182 chr17:61823672 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.62 7.83 0.43 1.16e-13 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2742234 0.554 rs1270015 chr10:43698240 G/T cg15436174 chr10:43711423 RASGEF1A 0.5 5.88 0.34 1.24e-8 Hirschsprung disease; CESC cis rs240768 0.511 rs61289570 chr6:101403098 C/T cg12253828 chr6:101329408 ASCC3 0.86 7.03 0.4 1.79e-11 Economic and political preferences (immigration/crime); CESC cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.22e-15 Colonoscopy-negative controls vs population controls; CESC cis rs929354 0.629 rs6950739 chr7:156982450 T/C cg05182265 chr7:156933206 UBE3C -0.51 -7.42 -0.41 1.63e-12 Body mass index; CESC cis rs67478160 0.704 rs12894254 chr14:104290949 G/C cg08213375 chr14:104286397 PPP1R13B 0.54 10.65 0.55 2.71e-22 Schizophrenia; CESC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg04772025 chr11:68637568 NA 0.5 5.96 0.34 8.13e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg11764359 chr7:65958608 NA -0.91 -14.86 -0.67 9.21e-37 Aortic root size; CESC cis rs7737355 0.812 rs12514547 chr5:130973304 C/G cg06307176 chr5:131281290 NA 0.38 5.06 0.3 7.77e-7 Life satisfaction; CESC cis rs4642101 0.597 rs9839768 chr3:12821403 C/T cg05775895 chr3:12838266 CAND2 0.41 6.3 0.36 1.2e-9 QRS complex (12-leadsum); CESC cis rs9911578 0.933 rs2531725 chr17:56517962 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.34 0.31 1.98e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 6.18e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg21782813 chr7:2030301 MAD1L1 0.5 7.17 0.4 7.6e-12 Bipolar disorder and schizophrenia; CESC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.71e-40 Aortic root size; CESC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg07157834 chr1:205819609 PM20D1 -0.71 -10.91 -0.56 4.02e-23 Menarche (age at onset); CESC cis rs287982 1.000 rs287980 chr2:9971366 G/A cg10881225 chr2:9984929 TAF1B -0.39 -5.12 -0.3 5.88e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs3942852 0.568 rs7479361 chr11:48109793 C/T cg15704280 chr7:45808275 SEPT13 -0.73 -9.2 -0.49 1.1e-17 Acute lymphoblastic leukemia (childhood); CESC cis rs7927771 1.000 rs11039426 chr11:47863119 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -6.0 -0.35 6.54e-9 Subjective well-being; CESC cis rs9486715 0.867 rs9373833 chr6:96904998 A/G cg06623918 chr6:96969491 KIAA0776 -0.92 -14.14 -0.66 3.24e-34 Headache; CESC cis rs6732160 0.525 rs2303907 chr2:73470497 T/C cg01422370 chr2:73384389 NA 0.44 7.59 0.42 5.48e-13 Intelligence (multi-trait analysis); CESC cis rs2274273 0.875 rs2075602 chr14:55609774 A/G cg04306507 chr14:55594613 LGALS3 0.29 5.79 0.34 2e-8 Protein biomarker; CESC cis rs6121246 0.559 rs6058468 chr20:30406448 C/A cg13852791 chr20:30311386 BCL2L1 0.86 10.97 0.56 2.48e-23 Mean corpuscular hemoglobin; CESC cis rs6500602 0.702 rs6500605 chr16:4502410 C/T cg08645402 chr16:4508243 NA 0.5 7.99 0.44 4.17e-14 Schizophrenia; CESC trans rs561341 0.740 rs11080174 chr17:30208521 C/A cg20587970 chr11:113659929 NA 0.59 7.5 0.42 9.74e-13 Hip circumference adjusted for BMI; CESC cis rs6912958 0.512 rs910563 chr6:88058885 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.33 5.56 0.32 6.64e-8 Monocyte percentage of white cells; CESC cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg22834771 chr12:69754056 YEATS4 -0.55 -7.29 -0.41 3.67e-12 Cerebrospinal fluid biomarker levels; CESC cis rs9309473 1.000 rs6546835 chr2:73664715 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.22 -0.36 1.97e-9 Metabolite levels; CESC cis rs4253772 0.637 rs8139035 chr22:46651367 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.18 0.45 1.16e-14 LDL cholesterol;Cholesterol, total; CESC cis rs12681366 0.537 rs2919656 chr8:95473034 C/T cg13257157 chr8:95487014 RAD54B 0.45 5.44 0.32 1.23e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs1878931 0.501 rs4785934 chr16:3419934 G/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.78 10.51 0.54 7.76e-22 Body mass index (adult); CESC cis rs748404 0.697 rs501884 chr15:43553982 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.61 8.03 0.44 3.2e-14 Lung cancer; CESC cis rs2228479 0.850 rs11644804 chr16:89976224 G/A cg04013166 chr16:89971882 TCF25 0.65 6.46 0.37 5.1e-10 Skin colour saturation; CESC cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg05340658 chr4:99064831 C4orf37 0.76 11.17 0.57 5.6e-24 Colonoscopy-negative controls vs population controls; CESC cis rs1034435 0.755 rs6007869 chr22:48894213 A/G cg05992904 chr22:48892994 FAM19A5 -0.57 -9.81 -0.52 1.35e-19 Late-onset Alzheimer's disease; CESC cis rs4423214 0.592 rs78300366 chr11:71205514 A/G cg05163923 chr11:71159392 DHCR7 -0.57 -5.83 -0.34 1.64e-8 Vitamin D levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05942963 chr14:71787552 NA -0.39 -6.07 -0.35 4.52e-9 Gambling; CESC cis rs9527 0.590 rs11191572 chr10:104893137 A/G cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg10556349 chr10:835070 NA 0.58 5.48 0.32 1e-7 Eosinophil percentage of granulocytes; CESC cis rs2204008 0.754 rs11181244 chr12:38302454 T/C cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Bladder cancer; CESC trans rs677673 1.000 rs649368 chr20:10473109 A/G cg16021678 chr13:55475951 NA 0.52 6.67 0.38 1.44e-10 Body mass index (change over time) in chronic obstructive pulmonary disease; CESC cis rs5753618 0.583 rs34545960 chr22:31812462 G/A cg02404636 chr22:31891804 SFI1 0.39 5.37 0.31 1.71e-7 Colorectal cancer; CESC cis rs6598955 0.670 rs3795688 chr1:26560481 C/A cg00852783 chr1:26633632 UBXN11 0.42 6.17 0.35 2.55e-9 Obesity-related traits; CESC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg17372223 chr3:52568218 NT5DC2 0.43 6.43 0.37 5.84e-10 Bipolar disorder; CESC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.61 7.63 0.42 4.34e-13 Tonsillectomy; CESC cis rs1784581 0.588 rs6455789 chr6:162417948 C/T cg17173639 chr6:162384350 PARK2 0.56 8.62 0.47 6.34e-16 Itch intensity from mosquito bite; CESC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg22823121 chr1:150693482 HORMAD1 0.48 7.07 0.4 1.36e-11 Tonsillectomy; CESC cis rs7598759 0.679 rs6740843 chr2:232332139 A/C cg19187155 chr2:232395269 NMUR1 0.39 6.12 0.35 3.33e-9 Noise-induced hearing loss; CESC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.78 9.43 0.5 2.15e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs6831352 0.918 rs13112733 chr4:100050319 A/T cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs11809207 0.523 rs2783706 chr1:26504697 A/G cg00147160 chr1:26503991 CNKSR1 0.27 5.13 0.3 5.58e-7 Height; CESC cis rs892961 0.899 rs7222532 chr17:75413302 G/C cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC trans rs4843747 0.671 rs4075998 chr16:88106776 G/A cg26811252 chr16:29126840 RRN3P2 0.67 9.46 0.5 1.77e-18 Menopause (age at onset); CESC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg07090678 chr1:91966139 CDC7 -0.41 -5.65 -0.33 4.18e-8 Breast cancer; CESC cis rs919433 0.680 rs12621129 chr2:198265350 T/C cg10820045 chr2:198174542 NA -0.38 -5.05 -0.3 8.29e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs11264213 0.686 rs645383 chr1:36373823 C/G cg27506609 chr1:36549197 TEKT2 -0.45 -5.95 -0.34 8.23e-9 Schizophrenia; CESC cis rs3008870 1.000 rs975451 chr1:67480060 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.01 13.78 0.65 5.96e-33 Lymphocyte percentage of white cells; CESC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.13 0.3 5.61e-7 Bipolar disorder; CESC cis rs2367563 0.930 rs7957253 chr12:96054414 G/A cg19013339 chr12:96052514 NTN4 0.37 5.35 0.31 1.9e-7 Allergic dermatitis (nickel); CESC cis rs6424115 0.729 rs561733 chr1:24049595 T/G cg10978503 chr1:24200527 CNR2 0.27 5.32 0.31 2.24e-7 Immature fraction of reticulocytes; CESC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg06481639 chr22:41940642 POLR3H 0.6 5.95 0.34 8.27e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs10743315 0.557 rs17505123 chr12:19301353 G/A cg02471346 chr12:19282374 PLEKHA5 0.76 5.82 0.34 1.7e-8 Gut microbiota (bacterial taxa); CESC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.54 7.24 0.41 4.73e-12 Bipolar disorder; CESC cis rs950027 0.584 rs1145086 chr15:45654327 A/G cg21132104 chr15:45694354 SPATA5L1 0.67 8.55 0.46 1.01e-15 Response to fenofibrate (adiponectin levels); CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg25190999 chr2:8826175 NA -0.57 -7.07 -0.4 1.35e-11 Gut microbiota (bacterial taxa); CESC cis rs116095464 0.558 rs7731089 chr5:290422 A/C cg22857025 chr5:266934 NA -1.29 -18.38 -0.75 3.21e-49 Breast cancer; CESC trans rs629535 0.814 rs477200 chr8:70059584 A/G cg21567404 chr3:27674614 NA 0.84 9.94 0.52 5.42e-20 Dupuytren's disease; CESC cis rs9309473 0.607 rs7560272 chr2:73561485 A/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.72 -0.38 1.09e-10 Metabolite levels; CESC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.48 0.81 2.38e-63 Prudent dietary pattern; CESC cis rs36051895 0.632 rs12336875 chr9:5138404 C/A cg02405213 chr9:5042618 JAK2 -0.5 -6.11 -0.35 3.45e-9 Pediatric autoimmune diseases; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24594383 chr20:62564955 DNAJC5 0.47 6.52 0.37 3.58e-10 Fibrinogen levels; CESC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg02275930 chr1:2372054 NA -0.54 -8.76 -0.47 2.45e-16 Non-obstructive azoospermia; CESC cis rs854765 0.505 rs4924832 chr17:17897739 A/G cg16928487 chr17:17741425 SREBF1 -0.57 -9.92 -0.52 6.42e-20 Total body bone mineral density; CESC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg17372223 chr3:52568218 NT5DC2 0.51 7.91 0.44 6.95e-14 Electroencephalogram traits; CESC cis rs77216612 0.877 rs66561220 chr12:12878765 T/C cg09462578 chr12:12878428 APOLD1 -1.01 -15.4 -0.69 1.18e-38 Lymphocyte counts; CESC cis rs7568458 0.684 rs7579147 chr2:85805654 G/A cg02493740 chr2:85810744 VAMP5 -0.57 -8.33 -0.46 4.26e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg18904891 chr8:8559673 CLDN23 -0.42 -5.16 -0.3 4.88e-7 Mood instability; CESC cis rs7923609 0.812 rs10822155 chr10:65071215 C/A cg01631684 chr10:65280961 REEP3 -0.41 -5.11 -0.3 6.16e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs3820068 0.608 rs7516683 chr1:16020502 A/G cg17385448 chr1:15911702 AGMAT -0.38 -6.1 -0.35 3.74e-9 Systolic blood pressure; CESC cis rs2933343 0.700 rs1683779 chr3:128642048 A/G cg24203234 chr3:128598194 ACAD9 0.41 5.57 0.32 6.41e-8 IgG glycosylation; CESC cis rs2279817 0.818 rs867984 chr1:17982559 G/A cg21791023 chr1:18019539 ARHGEF10L -0.61 -7.59 -0.42 5.36e-13 Neuroticism; CESC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg18876405 chr7:65276391 NA -0.53 -7.27 -0.41 4.11e-12 Aortic root size; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg06096994 chr13:41635664 WBP4 0.46 6.35 0.36 9.37e-10 Bronchopulmonary dysplasia; CESC cis rs7772486 0.764 rs2247211 chr6:146216379 G/A cg05347473 chr6:146136440 FBXO30 0.53 6.92 0.39 3.46e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7660520 0.524 rs4862101 chr4:183733177 T/C cg03209412 chr4:183728196 NA 0.59 5.24 0.31 3.23e-7 Pediatric autoimmune diseases; CESC cis rs4660261 0.526 rs2906466 chr1:44322220 A/G cg12908607 chr1:44402522 ARTN -0.46 -6.6 -0.38 2.29e-10 Intelligence (multi-trait analysis); CESC cis rs10465746 0.967 rs28567085 chr1:84428859 G/A cg10977910 chr1:84465055 TTLL7 0.46 6.18 0.35 2.45e-9 Obesity-related traits; CESC cis rs10743315 0.778 rs1586843 chr12:19354550 T/C cg02471346 chr12:19282374 PLEKHA5 -0.47 -5.15 -0.3 5.09e-7 Gut microbiota (bacterial taxa); CESC cis rs9902453 0.584 rs3809790 chr17:27955540 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.53 -6.64 -0.38 1.78e-10 Coffee consumption (cups per day); CESC cis rs7819412 0.745 rs4841498 chr8:10985432 C/T cg21775007 chr8:11205619 TDH -0.47 -6.88 -0.39 4.24e-11 Triglycerides; CESC cis rs765787 0.556 rs10851422 chr15:45513738 T/C cg24006582 chr15:45444508 DUOX1 0.54 6.55 0.37 2.97e-10 Uric acid levels; CESC cis rs524023 0.837 rs12362590 chr11:64352540 T/A cg07220939 chr11:64358617 SLC22A12 -0.33 -5.22 -0.31 3.57e-7 Urate levels in obese individuals; CESC trans rs11098499 1.000 rs6837898 chr4:120179154 C/T cg25214090 chr10:38739885 LOC399744 0.64 8.58 0.47 8.37e-16 Corneal astigmatism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20962746 chr11:118436826 C11orf60 0.4 5.99 0.35 6.68e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9929218 0.817 rs3114399 chr16:68713385 C/G cg02972257 chr16:68554789 NA 0.52 5.29 0.31 2.52e-7 Colorectal cancer; CESC cis rs6740322 0.748 rs6755601 chr2:43483044 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.76 -8.95 -0.48 6.23e-17 Coronary artery disease; CESC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg04756594 chr16:24857601 SLC5A11 0.46 5.66 0.33 3.88e-8 Intelligence (multi-trait analysis); CESC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs16854884 0.690 rs35885310 chr3:143771333 A/G cg06585982 chr3:143692056 C3orf58 0.48 6.18 0.35 2.46e-9 Economic and political preferences (feminism/equality); CESC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg17372223 chr3:52568218 NT5DC2 -0.43 -6.0 -0.35 6.53e-9 Bipolar disorder; CESC cis rs3815700 1.000 rs8109768 chr19:33095463 A/G cg02997394 chr19:33096574 ANKRD27 0.71 7.07 0.4 1.39e-11 Eosinophilic esophagitis; CESC cis rs950776 0.518 rs62008194 chr15:78813805 G/T cg24631222 chr15:78858424 CHRNA5 -0.41 -5.21 -0.3 3.86e-7 Sudden cardiac arrest; CESC cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg12923728 chr3:195709715 SDHAP1 -0.67 -8.86 -0.48 1.23e-16 Pancreatic cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09242721 chr3:3168535 TRNT1 0.6 6.83 0.39 5.88e-11 Gut microbiome composition (summer); CESC cis rs9467711 0.606 rs1977 chr6:26377546 A/G cg12826209 chr6:26865740 GUSBL1 0.63 5.79 0.33 2.04e-8 Autism spectrum disorder or schizophrenia; CESC cis rs2070488 0.804 rs35463537 chr3:38498248 T/C cg24069376 chr3:38537580 EXOG 0.33 5.59 0.32 5.58e-8 Electrocardiographic conduction measures; CESC cis rs11792861 0.591 rs10979613 chr9:111687584 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.62 9.5 0.5 1.29e-18 Menarche (age at onset); CESC cis rs10791323 0.569 rs10750541 chr11:133713189 A/C cg15485101 chr11:133734466 NA -0.42 -6.64 -0.38 1.75e-10 Childhood ear infection; CESC cis rs6121246 0.909 rs7272062 chr20:30259145 A/G cg13852791 chr20:30311386 BCL2L1 0.81 8.49 0.46 1.51e-15 Mean corpuscular hemoglobin; CESC cis rs3105593 1.000 rs17645523 chr15:50882645 T/C cg08437265 chr15:50716283 USP8 0.42 5.46 0.32 1.1e-7 QT interval; CESC cis rs8141529 0.664 rs5762861 chr22:29250505 T/G cg15103426 chr22:29168792 CCDC117 0.52 6.49 0.37 4.28e-10 Lymphocyte counts; CESC cis rs9457247 1.000 rs444988 chr6:167389674 A/T cg25258033 chr6:167368657 RNASET2 0.38 5.72 0.33 2.82e-8 Crohn's disease; CESC cis rs7727544 0.636 rs2631365 chr5:131705949 T/C cg24060327 chr5:131705240 SLC22A5 0.67 8.93 0.48 7.55e-17 Blood metabolite levels; CESC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg24531977 chr5:56204891 C5orf35 -0.87 -11.43 -0.57 7.1e-25 Initial pursuit acceleration; CESC cis rs7927592 0.731 rs488381 chr11:68291693 G/A cg01657329 chr11:68192670 LRP5 0.49 6.56 0.37 2.78e-10 Total body bone mineral density; CESC trans rs208520 1.000 rs208523 chr6:66954195 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -9.42 -0.5 2.36e-18 Exhaled nitric oxide output; CESC cis rs9486719 1.000 rs2472886 chr6:96864876 C/T cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs400736 0.894 rs226253 chr1:8027706 T/C cg25007680 chr1:8021821 PARK7 0.71 10.15 0.53 1.15e-20 Response to antidepressants and depression; CESC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.06e-7 Aortic root size; CESC cis rs904092 0.678 rs1230020 chr4:100175407 G/A cg12011299 chr4:100065546 ADH4 0.52 6.04 0.35 5.15e-9 Alcohol dependence; CESC cis rs2439831 0.681 rs478104 chr15:43594900 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.9 13.48 0.64 6.76e-32 Lung cancer in ever smokers; CESC cis rs4588572 0.643 rs1529499 chr5:77721431 T/C cg11547950 chr5:77652471 NA -0.44 -5.59 -0.32 5.64e-8 Triglycerides; CESC trans rs1003719 0.715 rs762139 chr21:38568475 A/T cg00295448 chr5:140044129 WDR55 -0.44 -6.28 -0.36 1.41e-9 Eye color traits; CESC cis rs7542091 0.704 rs1883331 chr1:210043483 A/G cg21951975 chr1:209979733 IRF6 0.47 8.25 0.45 7.51e-15 Monobrow; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09717923 chr16:1440498 NA -0.56 -6.8 -0.39 7.07e-11 Gut microbiome composition (summer); CESC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg17143192 chr8:8559678 CLDN23 -0.45 -5.69 -0.33 3.44e-8 Mood instability; CESC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.18 0.36 2.37e-9 Bipolar disorder; CESC cis rs1153858 1.000 rs16942568 chr15:45677390 T/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg09365446 chr1:150670422 GOLPH3L 0.39 5.1 0.3 6.59e-7 Melanoma; CESC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.01 0.56 1.89e-23 Platelet count; CESC cis rs9875589 0.509 rs1844107 chr3:14065319 C/G cg19554555 chr3:13937349 NA -0.44 -5.6 -0.33 5.43e-8 Ovarian reserve; CESC cis rs11122272 0.735 rs2572252 chr1:231513653 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs16854884 0.657 rs7610378 chr3:143711298 G/A cg01302019 chr3:143689584 C3orf58 -0.34 -5.08 -0.3 7.28e-7 Economic and political preferences (feminism/equality); CESC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg25767906 chr1:53392781 SCP2 0.44 6.11 0.35 3.45e-9 Monocyte count; CESC cis rs2933343 0.729 rs1680780 chr3:128612659 G/C cg11901034 chr3:128598214 ACAD9 -0.36 -5.16 -0.3 4.75e-7 IgG glycosylation; CESC cis rs62432291 0.681 rs3003174 chr6:159655326 T/C cg14500486 chr6:159655392 FNDC1 -0.62 -6.21 -0.36 2.04e-9 Joint mobility (Beighton score); CESC cis rs7223966 0.960 rs113155878 chr17:61706560 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.16 0.35 2.7e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2797160 0.547 rs1418645 chr6:125946476 T/A cg05901451 chr6:126070800 HEY2 -0.39 -5.33 -0.31 2.05e-7 Endometrial cancer; CESC cis rs17764205 0.777 rs113305163 chr19:3252194 G/C cg02612712 chr19:3985498 EEF2 0.67 5.32 0.31 2.21e-7 Bipolar disorder and schizophrenia; CESC cis rs9487051 0.676 rs2222392 chr6:109602303 T/C cg21918786 chr6:109611834 NA -0.39 -5.75 -0.33 2.5e-8 Reticulocyte fraction of red cells; CESC cis rs910316 0.875 rs12588099 chr14:75594462 A/T cg11812906 chr14:75593930 NEK9 0.88 15.16 0.68 8.23e-38 Height; CESC cis rs10883723 0.847 rs3808934 chr10:104264280 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.58 6.71 0.38 1.16e-10 Menopause (age at onset); CESC cis rs7246657 0.943 rs8111782 chr19:37867904 A/G cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs7937682 0.921 rs12806479 chr11:111443192 G/C cg09085632 chr11:111637200 PPP2R1B 0.91 10.76 0.55 1.24e-22 Primary sclerosing cholangitis; CESC cis rs9462846 0.959 rs6937172 chr6:42884375 A/T cg02353165 chr6:42928485 GNMT 0.49 5.6 0.33 5.42e-8 Blood protein levels; CESC cis rs17039065 0.920 rs1017430 chr4:109474062 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.6 5.25 0.31 3.17e-7 Gut microbiome composition (summer); CESC cis rs12701220 0.595 rs12532837 chr7:1122851 T/A cg26769984 chr7:1090371 C7orf50 0.56 6.08 0.35 4.18e-9 Bronchopulmonary dysplasia; CESC cis rs7605827 0.930 rs2287264 chr2:15637592 C/G cg19274914 chr2:15703543 NA 0.36 6.32 0.36 1.13e-9 Educational attainment (years of education); CESC cis rs818427 0.548 rs374613 chr5:112192072 A/G cg07820702 chr5:112228657 REEP5 0.39 5.28 0.31 2.66e-7 Total body bone mineral density; CESC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg26343298 chr8:95960752 TP53INP1 0.36 5.95 0.34 8.41e-9 Type 2 diabetes; CESC cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg23462726 chr11:62437636 C11orf83;C11orf48 -0.42 -5.35 -0.31 1.86e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2985684 1.000 rs56098064 chr14:50105849 T/C cg02151108 chr14:50098012 C14orf104 -0.39 -5.12 -0.3 5.78e-7 Carotid intima media thickness; CESC cis rs2276314 0.857 rs6507158 chr18:33636066 A/C cg05985134 chr18:33552581 C18orf21 0.61 7.3 0.41 3.39e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs9858542 0.953 rs35115732 chr3:49475155 T/C cg03060546 chr3:49711283 APEH -0.53 -5.96 -0.34 7.95e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg17376030 chr22:41985996 PMM1 -0.72 -7.6 -0.42 5.27e-13 Vitiligo; CESC cis rs28374715 0.580 rs8030228 chr15:41636867 A/G cg18705301 chr15:41695430 NDUFAF1 -0.92 -13.86 -0.65 3.33e-33 Ulcerative colitis; CESC cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg11657440 chr19:46296263 DMWD 0.81 12.61 0.61 7.09e-29 Coronary artery disease; CESC cis rs7666738 0.791 rs10022061 chr4:98926821 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg05347473 chr6:146136440 FBXO30 -0.55 -7.07 -0.4 1.41e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9815354 0.951 rs6793520 chr3:41865289 C/G cg03022575 chr3:42003672 ULK4 0.47 5.24 0.31 3.33e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs1697139 0.583 rs1428475 chr5:66543954 G/T cg11553311 chr5:66541588 NA 0.39 5.44 0.32 1.21e-7 Breast cancer; CESC cis rs34172651 0.917 rs6497756 chr16:24798291 G/T cg06028605 chr16:24865363 SLC5A11 0.35 5.49 0.32 9.29e-8 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27376437 chr17:56064565 VEZF1 0.44 6.01 0.35 6.21e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs727505 0.866 rs67132333 chr7:124719801 A/G cg23710748 chr7:124431027 NA -0.4 -6.55 -0.37 3.01e-10 Lewy body disease; CESC cis rs12477438 1.000 rs995617 chr2:99857904 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.74 8.64 0.47 5.28e-16 Chronic sinus infection; CESC cis rs3857536 0.813 rs7771569 chr6:66946717 C/T cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs888194 0.677 rs2164743 chr12:109875163 C/T cg19025524 chr12:109796872 NA -0.4 -6.03 -0.35 5.59e-9 Neuroticism; CESC cis rs7312774 0.618 rs7975954 chr12:107345750 C/T cg16260113 chr12:107380972 MTERFD3 0.82 7.48 0.42 1.11e-12 Severe influenza A (H1N1) infection; CESC cis rs1256061 0.646 rs1256056 chr14:64712626 A/G cg21174375 chr14:64681225 SYNE2 0.5 6.84 0.39 5.41e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs1559088 1.000 rs7256328 chr19:33558705 G/C cg27124370 chr19:33622961 WDR88 0.42 5.32 0.31 2.16e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg07507251 chr3:52567010 NT5DC2 0.39 6.45 0.37 5.14e-10 Bipolar disorder; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg02974499 chr11:64889668 FAU;MRPL49 0.53 6.05 0.35 4.99e-9 Psoriatic arthritis; CESC cis rs9303401 0.659 rs16943176 chr17:56769887 G/A cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC cis rs7580658 0.963 rs9789510 chr2:128137012 G/A cg10021288 chr2:128175891 PROC -0.4 -6.23 -0.36 1.84e-9 Protein C levels; CESC cis rs6089584 0.507 rs6061990 chr20:60628429 T/G cg06108461 chr20:60628389 TAF4 -0.57 -7.6 -0.42 5.04e-13 Body mass index; CESC cis rs13102973 0.899 rs17496 chr4:135900227 C/T cg14419869 chr4:135874104 NA -0.34 -5.05 -0.3 8.38e-7 Subjective well-being; CESC trans rs9850225 0.719 rs4856616 chr3:80466481 A/C cg22792938 chr2:228337242 AGFG1 0.37 6.08 0.35 4.17e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg13206674 chr6:150067644 NUP43 0.44 6.46 0.37 4.86e-10 Lung cancer; CESC cis rs4728302 0.869 rs10253633 chr7:133590869 A/G cg10665199 chr7:133106180 EXOC4 0.39 5.39 0.31 1.55e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg11366901 chr6:160182831 ACAT2 0.64 8.17 0.45 1.24e-14 Age-related macular degeneration (geographic atrophy); CESC trans rs2502399 0.667 rs1040591 chr6:113491096 A/T cg00285294 chr7:1089767 C7orf50 -0.35 -6.41 -0.37 6.56e-10 Plasma clusterin levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05414835 chr15:59225898 SLTM -0.45 -6.1 -0.35 3.68e-9 Gut microbiota (bacterial taxa); CESC cis rs12142240 0.659 rs67547686 chr1:46832229 G/C cg10495392 chr1:46806563 NSUN4 0.57 6.24 0.36 1.74e-9 Menopause (age at onset); CESC cis rs6460942 0.915 rs62447638 chr7:12484667 G/A cg20607287 chr7:12443886 VWDE -0.76 -8.58 -0.47 8.16e-16 Coronary artery disease; CESC trans rs2530545 0.851 rs1582278 chr7:34692925 C/A cg14080982 chr15:71736038 THSD4 -0.48 -6.05 -0.35 5.02e-9 IgG glycosylation; CESC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg04414720 chr1:150670196 GOLPH3L 0.56 7.5 0.42 9.36e-13 Melanoma; CESC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg11644478 chr21:40555479 PSMG1 1.0 14.59 0.67 8.82e-36 Cognitive function; CESC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg17178900 chr1:205818956 PM20D1 -0.4 -5.31 -0.31 2.29e-7 Parkinson's disease; CESC cis rs9467711 0.790 rs72843784 chr6:26498758 G/T cg21479132 chr6:26055353 NA 0.92 5.83 0.34 1.61e-8 Autism spectrum disorder or schizophrenia; CESC cis rs7044106 0.762 rs4837790 chr9:123446325 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.09 0.53 1.84e-20 Hip circumference adjusted for BMI; CESC cis rs60871478 0.579 rs56109762 chr7:925967 G/A cg05535760 chr7:792225 HEATR2 -0.83 -7.72 -0.43 2.38e-13 Cerebrospinal P-tau181p levels; CESC cis rs3862030 0.503 rs10786673 chr10:104280537 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.18 0.3 4.34e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs1559088 0.576 rs4805852 chr19:33609441 C/T cg17764715 chr19:33622953 WDR88 0.59 8.41 0.46 2.55e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs60843830 1.000 rs36216559 chr2:262335 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.69 8.65 0.47 5.11e-16 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs910316 0.763 rs175036 chr14:75464295 C/T cg16144293 chr14:75469539 EIF2B2 0.41 5.43 0.32 1.24e-7 Height; CESC cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -7.94 -0.44 5.82e-14 Personality dimensions; CESC cis rs7044106 0.791 rs10985004 chr9:123484937 T/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.51 0.32 8.6e-8 Hip circumference adjusted for BMI; CESC cis rs911555 0.504 rs745079 chr14:104073551 G/A cg24130564 chr14:104152367 KLC1 -0.82 -13.38 -0.63 1.58e-31 Intelligence (multi-trait analysis); CESC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg23131131 chr22:24373011 LOC391322 -0.7 -9.86 -0.52 9.82e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7216064 1.000 rs9913471 chr17:65874495 C/T cg07042672 chr17:66097459 LOC651250 -0.56 -6.5 -0.37 3.96e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg11644478 chr21:40555479 PSMG1 -0.53 -7.15 -0.4 8.54e-12 Menarche (age at onset); CESC cis rs17761864 0.718 rs8064885 chr17:2047564 G/A cg16513277 chr17:2031491 SMG6 0.4 5.05 0.3 8.19e-7 Esophageal cancer (squamous cell); CESC cis rs2243480 0.803 rs35480979 chr7:65357084 A/G cg13147721 chr7:65941812 NA -0.85 -8.51 -0.46 1.26e-15 Diabetic kidney disease; CESC cis rs459571 0.959 rs465724 chr9:136910097 C/T cg13789015 chr9:136890014 NCRNA00094 0.55 7.93 0.44 6.1e-14 Platelet distribution width; CESC cis rs67311347 1.000 rs2276871 chr3:40499273 C/T cg24209194 chr3:40518798 ZNF619 0.56 7.45 0.42 1.31e-12 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25349574 chr17:4891291 CAMTA2 -0.58 -6.83 -0.39 5.84e-11 Gut microbiome composition (summer); CESC trans rs9329221 0.507 rs12678938 chr8:10016969 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.14 -0.35 2.98e-9 Neuroticism; CESC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg05617483 chr15:76483344 C15orf27 0.41 5.45 0.32 1.17e-7 Blood metabolite levels; CESC cis rs17376456 0.825 rs7715562 chr5:93222034 C/T cg25358565 chr5:93447407 FAM172A -1.02 -9.82 -0.52 1.34e-19 Diabetic retinopathy; CESC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg17376030 chr22:41985996 PMM1 0.66 7.08 0.4 1.3e-11 Vitiligo; CESC cis rs4699052 0.625 rs4481237 chr4:104254009 G/A cg16532752 chr4:104119610 CENPE -0.39 -5.47 -0.32 1.02e-7 Testicular germ cell tumor; CESC cis rs367615 0.959 rs2201016 chr5:108947287 T/C cg17395555 chr5:108820864 NA 0.49 6.85 0.39 5.11e-11 Colorectal cancer (SNP x SNP interaction); CESC cis rs1707322 1.000 rs4489497 chr1:46438698 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs877282 1.000 rs7100358 chr10:773681 G/A cg22713356 chr15:30763199 NA 1.12 11.27 0.57 2.42e-24 Uric acid levels; CESC cis rs17376456 0.741 rs10036829 chr5:93309897 G/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.33 0.31 2.15e-7 Diabetic retinopathy; CESC cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg18876405 chr7:65276391 NA 0.64 8.65 0.47 4.98e-16 Aortic root size; CESC cis rs453301 0.606 rs6601279 chr8:8908231 G/A cg15556689 chr8:8085844 FLJ10661 -0.5 -5.96 -0.34 7.83e-9 Joint mobility (Beighton score); CESC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.44 6.16 0.35 2.7e-9 Menopause (age at onset); CESC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg11644478 chr21:40555479 PSMG1 1.01 16.84 0.72 9.25e-44 Cognitive function; CESC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg20243544 chr17:37824526 PNMT 0.5 6.37 0.36 8.22e-10 Glomerular filtration rate (creatinine); CESC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg26304593 chr6:42947056 PEX6 -0.45 -5.67 -0.33 3.69e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg11644478 chr21:40555479 PSMG1 0.52 7.05 0.4 1.56e-11 Menarche (age at onset); CESC cis rs9640161 0.742 rs2108851 chr7:150019634 T/C cg10018233 chr7:150070692 REPIN1 0.46 7.29 0.41 3.59e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs11683229 0.704 rs13000344 chr2:63289734 T/G cg17519650 chr2:63277830 OTX1 -0.73 -5.75 -0.33 2.48e-8 Protein quantitative trait loci; CESC cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg12923728 chr3:195709715 SDHAP1 -0.69 -8.96 -0.48 6.06e-17 Pancreatic cancer; CESC cis rs12136530 0.593 rs11578302 chr1:19724835 A/G cg01832549 chr1:19774989 CAPZB -0.46 -6.42 -0.37 6.27e-10 Lead levels in blood; CESC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg05025164 chr4:1340916 KIAA1530 0.88 12.0 0.59 8.77e-27 Longevity; CESC cis rs4891159 0.570 rs690132 chr18:74117261 T/C cg24786174 chr18:74118243 ZNF516 0.85 16.07 0.7 4.75e-41 Longevity; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg07507251 chr3:52567010 NT5DC2 0.47 8.94 0.48 6.75e-17 Electroencephalogram traits; CESC cis rs2191566 0.576 rs420584 chr19:44495257 C/T cg20607764 chr19:44506953 ZNF230 0.45 5.69 0.33 3.38e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs2204008 0.837 rs12146734 chr12:38237079 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.52 1.51e-19 Bladder cancer; CESC cis rs9324022 0.929 rs72698718 chr14:101178555 G/A cg18089426 chr14:101175970 NA 0.61 7.68 0.43 3.17e-13 Plateletcrit; CESC trans rs3780486 0.846 rs7036812 chr9:33143822 T/C cg04842962 chr6:43655489 MRPS18A 0.98 18.21 0.75 1.33e-48 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03914988 chr16:4748545 ANKS3 -0.56 -6.86 -0.39 4.84e-11 Gut microbiome composition (summer); CESC trans rs3780486 0.757 rs10813949 chr9:33123464 G/A cg04842962 chr6:43655489 MRPS18A 1.0 18.71 0.75 2.35e-50 IgG glycosylation; CESC cis rs9811920 0.625 rs9847283 chr3:99910320 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.36 -5.57 -0.32 6.34e-8 Axial length; CESC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.47 0.46 1.74e-15 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04816434 chr15:22945077 CYFIP1 -0.64 -6.86 -0.39 4.9e-11 Gut microbiome composition (summer); CESC cis rs1190552 0.846 rs3742437 chr14:102965047 G/A cg18135206 chr14:102964638 TECPR2 0.42 5.28 0.31 2.71e-7 Blood protein levels; CESC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg19717773 chr7:2847554 GNA12 -0.46 -6.75 -0.38 9.53e-11 Height; CESC cis rs8060686 0.623 rs58388686 chr16:68075439 A/G cg26727032 chr16:67993705 SLC12A4 -0.59 -8.2 -0.45 1.05e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs2637266 0.783 rs1797500 chr10:78510400 G/A cg18941641 chr10:78392320 NA 0.43 8.41 0.46 2.58e-15 Pulmonary function; CESC cis rs11792861 0.816 rs17792434 chr9:111667319 C/T cg13535736 chr9:111863775 C9orf5 -0.46 -6.01 -0.35 6.06e-9 Menarche (age at onset); CESC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg17372223 chr3:52568218 NT5DC2 0.53 8.47 0.46 1.68e-15 Electroencephalogram traits; CESC cis rs950169 0.800 rs4842847 chr15:84931199 G/A cg17507749 chr15:85114479 UBE2QP1 0.56 6.24 0.36 1.74e-9 Schizophrenia; CESC cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7551222 0.752 rs11240755 chr1:204478649 C/T cg20240347 chr1:204465584 NA -0.28 -5.65 -0.33 4.03e-8 Schizophrenia; CESC cis rs6546537 0.714 rs17036759 chr2:69767029 C/T cg10773587 chr2:69614142 GFPT1 -0.65 -8.1 -0.45 2.03e-14 Serum thyroid-stimulating hormone levels; CESC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg09491104 chr22:46646882 C22orf40 -0.52 -6.43 -0.37 5.82e-10 LDL cholesterol;Cholesterol, total; CESC cis rs17125944 0.505 rs2295827 chr14:53174981 C/T cg00686598 chr14:53173677 PSMC6 1.36 11.75 0.59 5.93e-26 Alzheimer's disease (late onset); CESC cis rs4728302 0.869 rs12707131 chr7:133620982 A/G cg10665199 chr7:133106180 EXOC4 0.4 5.39 0.31 1.52e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg14393609 chr7:65229607 NA 0.53 7.22 0.41 5.5e-12 Aortic root size; CESC trans rs2018683 0.707 rs10279870 chr7:28968935 A/G cg19402173 chr7:128379420 CALU -0.53 -7.27 -0.41 4.13e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs16910800 0.689 rs7101825 chr11:23164951 C/G cg20040320 chr11:23191996 NA 0.58 6.16 0.35 2.72e-9 Cancer; CESC cis rs1045714 0.895 rs1107690 chr7:2640595 G/T cg20813462 chr7:2646259 IQCE 0.65 5.65 0.33 4.16e-8 Urate levels in lean individuals; CESC cis rs2832191 0.967 rs3787660 chr21:30520907 C/T cg24692254 chr21:30365293 RNF160 0.73 11.16 0.57 5.7e-24 Dental caries; CESC cis rs2439831 0.850 rs28564774 chr15:44125475 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.6 0.33 5.26e-8 Lung cancer in ever smokers; CESC cis rs9457247 0.508 rs6918286 chr6:167505829 C/T cg23791538 chr6:167370224 RNASET2 -0.45 -5.89 -0.34 1.2e-8 Crohn's disease; CESC cis rs1178968 0.901 rs1178953 chr7:72781277 A/G cg25889504 chr7:72793014 NA 0.52 5.54 0.32 7.16e-8 Triglyceride levels; CESC cis rs2479724 0.846 rs2254805 chr6:41846110 T/G cg17623882 chr6:41773611 USP49 -0.41 -5.78 -0.33 2.04e-8 Menarche (age at onset); CESC cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg03060546 chr3:49711283 APEH 0.51 6.17 0.35 2.58e-9 Parkinson's disease; CESC cis rs72829446 0.530 rs7222404 chr17:7384198 G/A cg02795151 chr17:7402630 POLR2A 0.55 5.86 0.34 1.41e-8 Androgen levels; CESC cis rs17253792 0.822 rs78323463 chr14:56045451 T/G cg01858014 chr14:56050164 KTN1 -0.99 -7.44 -0.42 1.43e-12 Putamen volume; CESC trans rs11098499 0.955 rs35197422 chr4:120169314 T/G cg25214090 chr10:38739885 LOC399744 0.63 8.31 0.45 4.87e-15 Corneal astigmatism; CESC cis rs17253792 0.822 rs75991559 chr14:56092419 A/T cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg00149659 chr3:10157352 C3orf10 0.73 8.89 0.48 9.97e-17 Alzheimer's disease; CESC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg24503407 chr1:205819492 PM20D1 0.82 12.81 0.62 1.43e-29 Menarche (age at onset); CESC cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 6.13 0.35 3.17e-9 Tonsillectomy; CESC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg17372223 chr3:52568218 NT5DC2 -0.44 -7.01 -0.4 1.99e-11 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13494355 chr1:1274420 DVL1 -0.54 -6.17 -0.35 2.57e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18361730 chr7:44047039 SPDYE1;POLR2J4 -0.57 -6.93 -0.39 3.15e-11 Gut microbiome composition (summer); CESC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg22800045 chr5:56110881 MAP3K1 -0.76 -8.66 -0.47 4.8e-16 Initial pursuit acceleration; CESC cis rs7828089 0.504 rs12676477 chr8:22266425 T/C cg13512537 chr8:22265999 SLC39A14 -0.4 -5.74 -0.33 2.58e-8 Verbal declarative memory; CESC cis rs17209837 0.607 rs7793196 chr7:87122847 A/G cg00919237 chr7:87102261 ABCB4 -0.44 -5.47 -0.32 1.02e-7 Gallbladder cancer; CESC cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg05340658 chr4:99064831 C4orf37 0.8 11.74 0.58 6.77e-26 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg10295955 chr4:187884368 NA -1.02 -18.0 -0.74 7.4e-48 Lobe attachment (rater-scored or self-reported); CESC cis rs1559088 1.000 rs7256328 chr19:33558705 G/C cg17764715 chr19:33622953 WDR88 0.45 5.62 0.33 4.92e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9467711 0.606 rs9393706 chr6:26361500 G/A cg12826209 chr6:26865740 GUSBL1 0.6 5.04 0.3 8.5e-7 Autism spectrum disorder or schizophrenia; CESC cis rs763121 0.853 rs2413544 chr22:39059404 A/C cg21395723 chr22:39101663 GTPBP1 0.43 5.37 0.31 1.74e-7 Menopause (age at onset); CESC cis rs10861342 1.000 rs7305712 chr12:105519188 A/T cg23923672 chr12:105501055 KIAA1033 -0.63 -5.45 -0.32 1.12e-7 IgG glycosylation; CESC cis rs4919694 1.000 rs74749600 chr10:104732996 T/C cg04362960 chr10:104952993 NT5C2 0.73 5.72 0.33 2.92e-8 Arsenic metabolism; CESC cis rs74781061 1.000 rs6495116 chr15:74885948 A/G cg17294928 chr15:75287854 SCAMP5 -0.5 -5.3 -0.31 2.48e-7 Endometriosis; CESC cis rs7208859 0.673 rs11652409 chr17:29182707 T/A cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs116095464 0.558 rs10079760 chr5:230778 A/G cg00938859 chr5:1591904 SDHAP3 0.6 6.58 0.37 2.55e-10 Breast cancer; CESC cis rs2228479 0.867 rs35542367 chr16:89965825 G/C cg14709524 chr16:89940631 TCF25 0.7 5.52 0.32 8.08e-8 Skin colour saturation; CESC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.51 6.04 0.35 5.07e-9 Breast cancer; CESC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg06481639 chr22:41940642 POLR3H 0.59 5.91 0.34 1.07e-8 Vitiligo; CESC cis rs854765 0.647 rs2974998 chr17:17995619 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 8.56 0.47 9.6e-16 Total body bone mineral density; CESC cis rs11098499 0.818 rs12498599 chr4:120468503 C/T cg09307838 chr4:120376055 NA 0.91 12.73 0.62 2.82e-29 Corneal astigmatism; CESC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg07507251 chr3:52567010 NT5DC2 0.35 5.94 0.34 8.7e-9 Intelligence (multi-trait analysis); CESC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.81 8.77 0.47 2.26e-16 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19855366 chr13:111267979 CARKD -0.46 -6.66 -0.38 1.54e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12451471 0.637 rs12452616 chr17:78090081 A/G cg24585782 chr17:78113791 EIF4A3 0.6 7.96 0.44 4.97e-14 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs2425143 0.730 rs6060626 chr20:34415073 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.67 5.49 0.32 9.63e-8 Blood protein levels; CESC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg11764359 chr7:65958608 NA 0.73 10.55 0.54 6.1e-22 Aortic root size; CESC cis rs1065852 0.526 rs739296 chr22:42389948 A/G cg22189786 chr22:42395067 WBP2NL -0.41 -5.11 -0.3 6.26e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg15147215 chr3:52552868 STAB1 -0.29 -5.03 -0.3 9.09e-7 Electroencephalogram traits; CESC cis rs2070488 0.775 rs4679066 chr3:38568527 A/G cg24069376 chr3:38537580 EXOG -0.32 -5.54 -0.32 7.32e-8 Electrocardiographic conduction measures; CESC cis rs4835473 0.897 rs6832722 chr4:144630583 C/G cg25736465 chr4:144833511 NA 0.4 6.09 0.35 3.86e-9 Immature fraction of reticulocytes; CESC cis rs8077577 0.895 rs6502640 chr17:18122485 G/A cg16794390 chr17:18148240 FLII 0.42 5.65 0.33 4.16e-8 Obesity-related traits; CESC cis rs4927850 0.709 rs6783079 chr3:195652708 T/C cg12923728 chr3:195709715 SDHAP1 -0.66 -7.81 -0.43 1.33e-13 Pancreatic cancer; CESC cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg23583168 chr7:148888333 NA -0.77 -11.24 -0.57 3.14e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg13119609 chr19:45449297 APOC2 0.47 7.76 0.43 1.87e-13 Blood protein levels; CESC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg19257562 chr1:2043853 PRKCZ 0.41 6.68 0.38 1.4e-10 Height; CESC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.5 0.37 3.98e-10 Bipolar disorder; CESC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg04317338 chr11:64019027 PLCB3 0.87 9.06 0.49 3.04e-17 Mean platelet volume; CESC cis rs5758659 0.714 rs5758574 chr22:42481400 G/C cg15557168 chr22:42548783 NA 0.43 6.56 0.37 2.81e-10 Cognitive function; CESC cis rs17293817 0.588 rs17221652 chr10:1416472 C/G cg04271617 chr10:1416546 ADARB2 -0.35 -5.6 -0.33 5.39e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20029123 chr22:30783486 RNF215 0.52 6.0 0.35 6.59e-9 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04381898 chr2:219082190 ARPC2 -0.46 -6.02 -0.35 5.69e-9 Ulcerative colitis; CESC cis rs7605827 0.930 rs10203196 chr2:15541154 A/T cg19274914 chr2:15703543 NA 0.34 6.12 0.35 3.44e-9 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13833525 chr11:819513 PNPLA2 0.57 6.2 0.36 2.13e-9 Gut microbiome composition (summer); CESC cis rs861020 1.000 rs632746 chr1:209982515 C/T cg05527609 chr1:210001259 C1orf107 1.07 13.45 0.64 8.92e-32 Orofacial clefts; CESC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg24549020 chr5:56110836 MAP3K1 0.47 5.77 0.33 2.2e-8 Initial pursuit acceleration; CESC cis rs9300255 0.722 rs28458312 chr12:123863265 G/T cg00376283 chr12:123451042 ABCB9 -0.58 -6.67 -0.38 1.45e-10 Neutrophil percentage of white cells; CESC cis rs17270561 0.609 rs17267614 chr6:25730027 A/C cg25753631 chr6:25732923 NA -0.28 -5.35 -0.31 1.95e-7 Iron status biomarkers; CESC cis rs60154123 0.730 rs12403947 chr1:210456524 A/G cg23283495 chr1:209979779 IRF6 -0.44 -5.5 -0.32 8.87e-8 Coronary artery disease; CESC cis rs10504229 0.575 rs59424848 chr8:57999219 T/C cg24829409 chr8:58192753 C8orf71 -0.42 -5.5 -0.32 8.75e-8 Developmental language disorder (linguistic errors); CESC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg06481639 chr22:41940642 POLR3H 0.52 5.58 0.32 5.84e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs2228479 0.541 rs12918575 chr16:89811151 A/G cg06558623 chr16:89946397 TCF25 0.79 7.45 0.42 1.32e-12 Skin colour saturation; CESC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg25985355 chr7:65971099 NA -0.33 -5.47 -0.32 1.04e-7 Aortic root size; CESC cis rs854765 0.583 rs8078138 chr17:17811251 C/T cg16928487 chr17:17741425 SREBF1 -0.59 -10.25 -0.53 5.51e-21 Total body bone mineral density; CESC cis rs2273669 0.667 rs77936298 chr6:109350616 A/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs11098499 0.863 rs13136462 chr4:120543173 C/T cg09307838 chr4:120376055 NA 0.88 12.02 0.59 7.35e-27 Corneal astigmatism; CESC cis rs910316 0.712 rs175074 chr14:75504454 G/A cg15467112 chr14:75489610 MLH3 -0.33 -5.11 -0.3 6.23e-7 Height; CESC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg17971929 chr21:40555470 PSMG1 -0.87 -12.83 -0.62 1.2e-29 Cognitive function; CESC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg17971929 chr21:40555470 PSMG1 0.98 13.28 0.63 3.31e-31 Cognitive function; CESC cis rs959260 1.000 rs4788891 chr17:73391145 A/G cg12999837 chr17:73267436 MIF4GD -0.48 -5.54 -0.32 7.21e-8 Systemic lupus erythematosus; CESC cis rs4253772 0.530 rs8140573 chr22:46800363 G/C cg24881330 chr22:46731750 TRMU 0.67 5.36 0.31 1.84e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9682041 0.597 rs62295834 chr3:170075701 G/A cg11886554 chr3:170076028 SKIL 0.54 5.31 0.31 2.32e-7 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg11247378 chr22:39784982 NA 0.62 9.48 0.5 1.49e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg12826209 chr6:26865740 GUSBL1 0.73 8.13 0.45 1.7e-14 Intelligence (multi-trait analysis); CESC cis rs7833986 0.534 rs10504198 chr8:57006254 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.54 0.42 7.58e-13 Height; CESC cis rs4253772 0.530 rs9615990 chr22:46804154 G/A cg18190219 chr22:46762943 CELSR1 -0.59 -6.11 -0.35 3.54e-9 LDL cholesterol;Cholesterol, total; CESC cis rs1865760 0.532 rs2794719 chr6:26088890 T/G cg16482183 chr6:26056742 HIST1H1C 0.4 5.43 0.32 1.25e-7 Height; CESC cis rs929354 0.742 rs10251112 chr7:156963524 A/G cg05182265 chr7:156933206 UBE3C -0.51 -7.47 -0.42 1.14e-12 Body mass index; CESC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg22549504 chr19:17448937 GTPBP3 0.49 5.35 0.31 1.88e-7 Systemic lupus erythematosus; CESC cis rs733592 0.931 rs765260 chr12:48431936 C/T cg24011408 chr12:48396354 COL2A1 -0.5 -8.03 -0.44 3.12e-14 Plateletcrit; CESC cis rs1707322 0.752 rs28507722 chr1:46206540 A/G cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg11752832 chr7:134001865 SLC35B4 0.52 6.57 0.37 2.64e-10 Mean platelet volume; CESC cis rs6942756 0.915 rs6966595 chr7:129006202 A/C cg02491457 chr7:128862824 NA -0.6 -8.39 -0.46 2.99e-15 White matter hyperintensity burden; CESC cis rs66573146 0.803 rs59742225 chr4:6969942 C/T cg00086871 chr4:6988644 TBC1D14 1.08 6.05 0.35 5e-9 Granulocyte percentage of myeloid white cells; CESC cis rs7927771 0.965 rs1064608 chr11:47640429 G/C cg05585544 chr11:47624801 NA -0.54 -8.42 -0.46 2.32e-15 Subjective well-being; CESC cis rs9739070 1 rs9739070 chr12:123771032 A/G cg00376283 chr12:123451042 ABCB9 0.57 6.45 0.37 5.36e-10 Allergy; CESC cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.36 5.17 0.3 4.59e-7 Schizophrenia; CESC cis rs7520050 0.966 rs10890352 chr1:46283628 G/A cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.38e-7 Red blood cell count;Reticulocyte count; CESC cis rs11122272 0.735 rs2749699 chr1:231520279 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs2290159 0.800 rs73812836 chr3:12655149 T/G cg23032965 chr3:12705835 RAF1 0.54 5.9 0.34 1.11e-8 Cholesterol, total; CESC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg11764359 chr7:65958608 NA -0.79 -11.58 -0.58 2.22e-25 Aortic root size; CESC trans rs7395662 0.553 rs4882155 chr11:48705801 T/C cg00717180 chr2:96193071 NA -0.45 -6.1 -0.35 3.83e-9 HDL cholesterol; CESC cis rs2625529 0.701 rs12911154 chr15:72212653 G/A cg16672083 chr15:72433130 SENP8 -0.39 -5.03 -0.3 9.17e-7 Red blood cell count; CESC cis rs3096299 0.866 rs4238829 chr16:89462262 G/A cg08392591 chr16:89556376 ANKRD11 0.41 5.28 0.31 2.64e-7 Multiple myeloma (IgH translocation); CESC trans rs10242455 0.702 rs3528 chr7:99055940 T/C cg09045935 chr12:6379348 NA 0.91 7.82 0.43 1.25e-13 Blood metabolite levels; CESC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg18876405 chr7:65276391 NA -0.54 -7.57 -0.42 6.03e-13 Aortic root size; CESC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9818758 0.607 rs71324929 chr3:49044713 C/T cg00383909 chr3:49044727 WDR6 0.89 5.83 0.34 1.62e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs9913156 0.670 rs4416072 chr17:4570036 C/T cg00122941 chr17:4613640 ARRB2 0.84 10.29 0.53 4.1e-21 Lymphocyte counts; CESC cis rs11098499 0.743 rs10003567 chr4:120241674 C/T cg09307838 chr4:120376055 NA 0.79 10.62 0.55 3.51e-22 Corneal astigmatism; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10134882 chr12:65563916 LEMD3 -0.41 -6.08 -0.35 4.07e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05521474 chr5:135082196 NA -0.54 -6.6 -0.38 2.25e-10 Gut microbiome composition (summer); CESC cis rs11711311 1.000 rs2566970 chr3:113462123 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.63 -9.09 -0.49 2.44e-17 IgG glycosylation; CESC cis rs9611565 0.659 rs9611604 chr22:41916001 C/G cg17376030 chr22:41985996 PMM1 0.76 8.2 0.45 1.04e-14 Vitiligo; CESC cis rs67366981 0.778 rs3952319 chr14:77684379 A/T cg22824376 chr14:77648248 TMEM63C 0.79 7.5 0.42 9.69e-13 Obsessive-compulsive symptoms; CESC trans rs2975734 0.676 rs4841299 chr8:10112593 A/C cg15556689 chr8:8085844 FLJ10661 -0.59 -6.73 -0.38 1.06e-10 Morning vs. evening chronotype;Chronotype; CESC cis rs722599 0.748 rs59112602 chr14:75358817 C/G cg08847533 chr14:75593920 NEK9 -0.46 -5.45 -0.32 1.18e-7 IgG glycosylation; CESC cis rs853679 1.000 rs2799077 chr6:28234597 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.7 7.39 0.41 1.88e-12 Depression; CESC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg03934478 chr11:495069 RNH1 0.56 5.36 0.31 1.84e-7 Body mass index; CESC cis rs9796 0.689 rs11855797 chr15:41434679 C/T cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.35 -0.36 9.34e-10 Menopause (age at onset); CESC cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg07636037 chr3:49044803 WDR6 1.03 19.1 0.76 9.82e-52 Parkinson's disease; CESC cis rs4242434 0.927 rs13264187 chr8:22506098 C/T cg14690197 chr8:22456421 C8orf58 0.37 5.03 0.3 9.01e-7 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs4243830 1.000 rs41278014 chr1:6579653 G/C cg22792644 chr1:6614718 TAS1R1;NOL9 0.82 6.74 0.38 9.6e-11 Body mass index; CESC trans rs61931739 0.534 rs35056575 chr12:34142914 A/T cg26384229 chr12:38710491 ALG10B 0.66 9.21 0.49 1.01e-17 Morning vs. evening chronotype; CESC cis rs9747201 1.000 rs9747668 chr17:80161081 A/G cg09264619 chr17:80180166 NA -0.44 -5.22 -0.31 3.67e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1003719 0.645 rs8131944 chr21:38547215 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.06 -0.44 2.72e-14 Eye color traits; CESC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg12379764 chr21:47803548 PCNT 0.46 5.85 0.34 1.47e-8 Testicular germ cell tumor; CESC cis rs3808502 0.647 rs7821302 chr8:11236572 T/A cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.52e-14 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04269569 chr16:8963018 CARHSP1 0.57 6.58 0.37 2.49e-10 Gut microbiome composition (summer); CESC cis rs2050392 0.517 rs7096279 chr10:30759608 C/T cg18806716 chr10:30721971 MAP3K8 -0.47 -7.27 -0.41 3.99e-12 Inflammatory bowel disease; CESC cis rs6460942 0.591 rs62451464 chr7:12363059 C/A cg20607287 chr7:12443886 VWDE -0.59 -6.43 -0.37 6.05e-10 Coronary artery disease; CESC cis rs734999 0.550 rs2985855 chr1:2531372 A/C cg20673091 chr1:2541236 MMEL1 -0.43 -7.12 -0.4 1.03e-11 Ulcerative colitis; CESC cis rs868036 1.000 rs4633663 chr15:68106378 G/C cg08079166 chr15:68083412 MAP2K5 0.43 6.92 0.39 3.35e-11 Restless legs syndrome; CESC cis rs2303759 0.543 rs7255778 chr19:49906608 G/A cg22307029 chr19:49891270 CCDC155 0.62 7.3 0.41 3.29e-12 Multiple sclerosis; CESC cis rs2204008 0.905 rs8189449 chr12:38437377 C/A cg13010199 chr12:38710504 ALG10B 0.42 5.43 0.32 1.28e-7 Bladder cancer; CESC cis rs2337406 0.714 rs7145254 chr14:107226016 A/G cg23076370 chr14:107095027 NA -0.55 -5.68 -0.33 3.57e-8 Alzheimer's disease (late onset); CESC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.82 0.39 6.17e-11 Bipolar disorder; CESC cis rs2404602 0.716 rs12441550 chr15:76863682 A/T cg26408565 chr15:76604113 ETFA -0.4 -5.72 -0.33 2.92e-8 Blood metabolite levels; CESC cis rs3820928 0.874 rs1114562 chr2:227788592 T/C cg05526886 chr2:227700861 RHBDD1 -0.46 -5.89 -0.34 1.16e-8 Pulmonary function; CESC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg15556689 chr8:8085844 FLJ10661 0.5 6.41 0.37 6.74e-10 Mood instability; CESC cis rs9287719 0.967 rs10929688 chr2:10756650 T/C cg00105475 chr2:10696890 NA 0.37 5.3 0.31 2.43e-7 Prostate cancer; CESC cis rs7219021 0.926 rs12150249 chr17:46852108 A/T cg16584676 chr17:46985605 UBE2Z -0.51 -5.84 -0.34 1.49e-8 Schizophrenia or bipolar disorder; CESC cis rs5417 0.775 rs222852 chr17:7140606 A/G cg25256661 chr17:7137939 DVL2 0.48 6.43 0.37 5.81e-10 Diastolic blood pressure; CESC cis rs6894249 1.000 rs6894249 chr5:131797547 A/G cg21138405 chr5:131827807 IRF1 0.37 6.07 0.35 4.44e-9 Asthma; CESC cis rs847577 0.609 rs7791463 chr7:97819047 G/A cg24562669 chr7:97807699 LMTK2 0.82 13.31 0.63 2.74e-31 Breast cancer; CESC cis rs921968 0.565 rs6436084 chr2:219639782 A/G cg02176678 chr2:219576539 TTLL4 -0.44 -7.74 -0.43 2.15e-13 Mean corpuscular hemoglobin concentration; CESC cis rs11122272 0.735 rs2749704 chr1:231526243 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.67 -0.43 3.27e-13 Hemoglobin concentration; CESC trans rs2882926 0.590 rs7835219 chr8:63525400 C/T cg07243138 chr11:105169034 NA -0.61 -6.3 -0.36 1.2e-9 Periodontitis (PAL4Q3); CESC cis rs6429082 0.764 rs291377 chr1:235695186 C/T cg26050004 chr1:235667680 B3GALNT2 -0.56 -6.64 -0.38 1.82e-10 Adiposity; CESC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg14159672 chr1:205819179 PM20D1 0.8 12.15 0.6 2.75e-27 Menarche (age at onset); CESC cis rs250677 0.687 rs250667 chr5:148455134 A/G cg18129178 chr5:148520854 ABLIM3 0.52 5.95 0.34 8.45e-9 Breast cancer; CESC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg03806693 chr22:41940476 POLR3H 1.19 14.1 0.65 4.45e-34 Vitiligo; CESC cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.46 -6.06 -0.35 4.59e-9 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12183124 chr6:43507374 XPO5 -0.68 -7.87 -0.44 8.95e-14 Gut microbiome composition (summer); CESC cis rs6496667 0.558 rs10459677 chr15:91042399 A/C cg22089800 chr15:90895588 ZNF774 -0.47 -5.92 -0.34 9.83e-9 Rheumatoid arthritis; CESC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 10.88 0.56 4.85e-23 Personality dimensions; CESC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg23708337 chr7:1209742 NA 0.55 5.47 0.32 1.04e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg05340658 chr4:99064831 C4orf37 0.76 11.17 0.57 5.6e-24 Colonoscopy-negative controls vs population controls; CESC cis rs12618769 0.597 rs4851136 chr2:99060873 A/T cg10123293 chr2:99228465 UNC50 0.39 5.18 0.3 4.49e-7 Bipolar disorder; CESC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs1185460 0.967 rs1786684 chr11:118938435 G/A cg23280166 chr11:118938394 VPS11 0.57 8.0 0.44 3.79e-14 Coronary artery disease; CESC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg16145915 chr7:1198662 ZFAND2A -0.43 -5.88 -0.34 1.24e-8 Longevity;Endometriosis; CESC cis rs473651 0.692 rs579511 chr2:239334914 C/G cg18131467 chr2:239335373 ASB1 1.03 20.34 0.78 4.85e-56 Multiple system atrophy; CESC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC trans rs8073060 0.544 rs225268 chr17:33966224 A/C cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.69 0.64 1.3e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10823157 chr18:76829834 ATP9B -0.68 -8.47 -0.46 1.76e-15 Gut microbiome composition (summer); CESC cis rs2549003 1.000 rs7734334 chr5:131815004 C/A cg21138405 chr5:131827807 IRF1 0.54 9.38 0.5 3.2e-18 Asthma (sex interaction); CESC cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg03467027 chr4:99064603 C4orf37 0.43 5.23 0.31 3.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs847577 0.609 rs17435847 chr7:97792820 G/A cg24562669 chr7:97807699 LMTK2 0.84 14.25 0.66 1.33e-34 Breast cancer; CESC cis rs2072732 0.861 rs2993510 chr1:2956666 C/T cg03976712 chr1:2946727 NA -0.31 -5.45 -0.32 1.13e-7 Plateletcrit; CESC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg25036284 chr2:26402008 FAM59B 0.67 7.26 0.41 4.38e-12 Gut microbiome composition (summer); CESC cis rs7216064 1.000 rs7210027 chr17:65977053 C/T cg07042672 chr17:66097459 LOC651250 0.6 7.54 0.42 7.61e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs916888 0.773 rs199447 chr17:44812188 C/T cg27589368 chr17:43923255 LOC100128977;IMP5 -0.4 -5.46 -0.32 1.11e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg20243544 chr17:37824526 PNMT -0.41 -5.13 -0.3 5.69e-7 Glomerular filtration rate (creatinine); CESC cis rs4835473 0.932 rs1813908 chr4:144649327 C/T cg25736465 chr4:144833511 NA 0.36 5.42 0.32 1.31e-7 Immature fraction of reticulocytes; CESC cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 10.6 0.55 4.02e-22 Personality dimensions; CESC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.48 -6.88 -0.39 4.43e-11 Menopause (age at onset); CESC cis rs7447593 0.518 rs4074995 chr5:176797343 C/T cg16006841 chr5:176797999 RGS14 0.58 6.26 0.36 1.59e-9 Urinary electrolytes (magnesium/calcium ratio); CESC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg14393609 chr7:65229607 NA -0.52 -7.07 -0.4 1.36e-11 Calcium levels; CESC cis rs11864453 0.928 rs3213420 chr16:72042433 C/T cg16558253 chr16:72132732 DHX38 -0.48 -7.15 -0.4 8.32e-12 Fibrinogen levels; CESC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.5 0.81 2.02e-63 Prudent dietary pattern; CESC cis rs36051895 0.594 rs7029244 chr9:5180961 A/C cg02405213 chr9:5042618 JAK2 -0.51 -6.68 -0.38 1.43e-10 Pediatric autoimmune diseases; CESC cis rs644799 0.965 rs10831426 chr11:95505888 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.66 0.67 4.91e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4727963 0.846 rs1608829 chr7:122707613 A/G cg03640110 chr7:122635026 TAS2R16 0.37 5.82 0.34 1.67e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs1372520 0.873 rs2737026 chr4:90779823 A/G cg15133208 chr4:90757351 SNCA -0.35 -5.03 -0.3 8.84e-7 Neuroticism; CESC cis rs4409675 0.576 rs7533918 chr1:28230667 G/A cg23691781 chr1:28212827 C1orf38 0.28 5.53 0.32 7.57e-8 Corneal astigmatism; CESC cis rs13191362 0.507 rs2510207 chr6:163086592 T/C cg14584255 chr6:163149320 PACRG;PARK2 -0.42 -5.2 -0.3 3.99e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03773196 chr1:219786527 NA -0.56 -7.42 -0.41 1.62e-12 Gut microbiome composition (summer); CESC cis rs7914558 0.966 rs3902934 chr10:104746649 A/G cg04362960 chr10:104952993 NT5C2 0.46 5.93 0.34 9.56e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs2727020 0.595 rs10839286 chr11:49497063 C/A cg03929089 chr4:120376271 NA -0.85 -13.5 -0.64 5.83e-32 Coronary artery disease; CESC cis rs7605827 0.780 rs34739027 chr2:15532146 C/A cg19274914 chr2:15703543 NA 0.36 6.46 0.37 5.01e-10 Educational attainment (years of education); CESC cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg08645402 chr16:4508243 NA 0.42 5.92 0.34 1.01e-8 Schizophrenia; CESC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg06453172 chr10:134556979 INPP5A -0.43 -5.58 -0.32 5.88e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg07701084 chr6:150067640 NUP43 0.42 5.6 0.33 5.37e-8 Lung cancer; CESC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg15445000 chr17:37608096 MED1 -0.4 -6.52 -0.37 3.49e-10 Glomerular filtration rate (creatinine); CESC cis rs4243830 1.000 rs12046884 chr1:6594561 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.78 6.18 0.36 2.36e-9 Body mass index; CESC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.84 0.43 1.14e-13 Prudent dietary pattern; CESC cis rs10089 1.000 rs1560636 chr5:127447987 A/G cg19767477 chr5:127420684 SLC12A2 -0.4 -5.55 -0.32 7.07e-8 Ileal carcinoids; CESC cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg12386194 chr3:101231763 SENP7 0.57 6.56 0.37 2.81e-10 Colonoscopy-negative controls vs population controls; CESC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg05872129 chr22:39784769 NA -0.85 -11.73 -0.58 7.18e-26 Intelligence (multi-trait analysis); CESC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg07414643 chr4:187882934 NA 0.56 8.14 0.45 1.53e-14 Lobe attachment (rater-scored or self-reported); CESC trans rs3942852 0.759 rs905475 chr11:48149755 C/T cg15704280 chr7:45808275 SEPT13 -0.65 -7.4 -0.41 1.8e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg06022373 chr22:39101656 GTPBP1 -0.88 -13.94 -0.65 1.63e-33 Menopause (age at onset); CESC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg21782813 chr7:2030301 MAD1L1 0.5 7.17 0.4 7.6e-12 Bipolar disorder and schizophrenia; CESC cis rs2486288 0.656 rs6493143 chr15:45570781 G/T cg09092052 chr15:45571596 NA 0.45 5.33 0.31 2.14e-7 Glomerular filtration rate; CESC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg02951883 chr7:2050386 MAD1L1 -0.47 -6.17 -0.35 2.52e-9 Bipolar disorder and schizophrenia; CESC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg17747265 chr1:1875780 NA -0.57 -9.13 -0.49 1.81e-17 Body mass index; CESC cis rs8040855 0.627 rs12900012 chr15:85590186 A/G cg08123816 chr15:85640762 PDE8A -0.36 -5.41 -0.32 1.39e-7 Bulimia nervosa; CESC cis rs3026445 0.791 rs7309141 chr12:110587637 G/A cg12870014 chr12:110450643 ANKRD13A 0.46 5.9 0.34 1.13e-8 QT interval; CESC cis rs367615 0.704 rs17161885 chr5:108852642 A/G cg17395555 chr5:108820864 NA 0.66 10.95 0.56 2.91e-23 Colorectal cancer (SNP x SNP interaction); CESC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs8070624 0.574 rs9914127 chr17:17875836 A/T cg04398451 chr17:18023971 MYO15A -0.75 -10.67 -0.55 2.48e-22 Total body bone mineral density; CESC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.08 -13.24 -0.63 4.53e-31 Gut microbiome composition (summer); CESC cis rs1881797 1.000 rs12081895 chr1:247686666 C/G cg18198730 chr1:247681584 NA 0.59 7.76 0.43 1.84e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg19774624 chr17:42201019 HDAC5 -0.69 -10.03 -0.52 2.7e-20 Total body bone mineral density; CESC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg12963246 chr6:28129442 ZNF389 0.49 6.34 0.36 9.71e-10 Parkinson's disease; CESC cis rs6430585 0.527 rs62168792 chr2:136415217 A/G cg07169764 chr2:136633963 MCM6 1.06 12.14 0.6 2.95e-27 Corneal structure; CESC cis rs9788682 0.747 rs7177514 chr15:78907406 C/G cg24631222 chr15:78858424 CHRNA5 0.78 9.74 0.51 2.36e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs684232 0.583 rs17677436 chr17:520314 T/C cg15660573 chr17:549704 VPS53 -0.81 -11.87 -0.59 2.38e-26 Prostate cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26998693 chr6:132834590 STX7 -0.47 -6.53 -0.37 3.33e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7786808 0.608 rs9692003 chr7:158204696 G/A cg09998033 chr7:158218633 PTPRN2 0.37 5.51 0.32 8.35e-8 Obesity-related traits; CESC cis rs7084402 0.967 rs1658435 chr10:60327527 A/G cg07615347 chr10:60278583 BICC1 0.59 9.44 0.5 2e-18 Refractive error; CESC cis rs35146811 0.586 rs6964754 chr7:99589404 G/A cg14163444 chr7:99595348 NA -0.39 -5.24 -0.31 3.3e-7 Coronary artery disease; CESC cis rs12477438 0.798 rs10167015 chr2:99570707 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.73 -10.32 -0.54 3.22e-21 Chronic sinus infection; CESC cis rs7267979 0.934 rs2261115 chr20:25259807 G/A cg08601574 chr20:25228251 PYGB 0.39 5.61 0.33 5e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs854765 0.583 rs4925126 chr17:17798633 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.63 9.26 0.49 7.2e-18 Total body bone mineral density; CESC cis rs2637266 1.000 rs12784382 chr10:78378348 G/T cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs7267979 1.000 rs2424716 chr20:25423538 G/A cg08601574 chr20:25228251 PYGB 0.38 5.57 0.32 6.24e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg00784671 chr22:46762841 CELSR1 -0.52 -5.49 -0.32 9.2e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9467711 0.790 rs1979 chr6:26377591 G/T cg14345882 chr6:26364793 BTN3A2 0.64 6.74 0.38 1.01e-10 Autism spectrum disorder or schizophrenia; CESC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg12963246 chr6:28129442 ZNF389 0.39 5.59 0.32 5.67e-8 Parkinson's disease; CESC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg05368731 chr17:41323189 NBR1 0.79 10.91 0.56 3.89e-23 Menopause (age at onset); CESC cis rs1451375 0.583 rs7776816 chr7:50583534 G/A cg14593290 chr7:50529359 DDC 0.5 6.09 0.35 3.87e-9 Malaria; CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg22143856 chr6:28129313 ZNF389 0.5 6.59 0.38 2.34e-10 Depression; CESC trans rs11098499 0.866 rs13105020 chr4:120285688 G/T cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs9583531 0.574 rs61971615 chr13:111353111 C/T cg24331049 chr13:111365604 ING1 -0.72 -10.45 -0.54 1.3e-21 Coronary artery disease; CESC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg08888203 chr3:10149979 C3orf24 -0.52 -6.98 -0.39 2.35e-11 Alzheimer's disease; CESC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.69 -0.33 3.36e-8 Depression; CESC cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg10523679 chr1:76189770 ACADM 0.66 6.27 0.36 1.44e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg27286337 chr10:134555280 INPP5A 0.61 6.89 0.39 4.15e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs3008870 0.755 rs4655662 chr1:67416432 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.63 8.38 0.46 3.04e-15 Lymphocyte percentage of white cells; CESC cis rs4474465 0.646 rs7927503 chr11:78280606 G/T cg27205649 chr11:78285834 NARS2 0.52 7.14 0.4 9.17e-12 Alzheimer's disease (survival time); CESC cis rs1941023 0.584 rs2241921 chr11:60164302 C/T cg08716584 chr11:60157161 MS4A7 -0.6 -10.27 -0.53 4.78e-21 Congenital heart disease (maternal effect); CESC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.67 0.64 1.49e-32 Prudent dietary pattern; CESC cis rs950776 0.518 rs12910289 chr15:78822065 T/G cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs2075371 0.830 rs1421478 chr7:133922793 T/A cg20476274 chr7:133979776 SLC35B4 0.61 8.77 0.47 2.26e-16 Mean platelet volume; CESC cis rs9457247 1.000 rs9457247 chr6:167392174 C/T cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.87e-8 Crohn's disease; CESC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg00934597 chr7:893267 UNC84A 0.56 5.65 0.33 4.17e-8 Cerebrospinal P-tau181p levels; CESC cis rs7666738 0.515 rs13434650 chr4:98889886 A/G cg05340658 chr4:99064831 C4orf37 0.58 7.15 0.4 8.28e-12 Colonoscopy-negative controls vs population controls; CESC cis rs4077515 1.000 rs10781499 chr9:139266405 G/A cg14169450 chr9:139327907 INPP5E 0.36 5.18 0.3 4.46e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs11252926 0.931 rs12358336 chr10:566981 A/T cg08603382 chr10:743973 NA -0.59 -7.47 -0.42 1.15e-12 Psychosis in Alzheimer's disease; CESC cis rs79387448 0.638 rs6741230 chr2:103069631 C/T cg09003973 chr2:102972529 NA 0.82 6.59 0.38 2.34e-10 Gut microbiota (bacterial taxa); CESC cis rs4268898 0.662 rs2303297 chr2:24432937 C/T cg20701182 chr2:24300061 SF3B14 0.68 7.16 0.4 7.75e-12 Asthma; CESC cis rs9814567 0.964 rs9820150 chr3:134223011 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -5.98 -0.35 7.05e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9894429 0.816 rs7406040 chr17:79597583 A/C cg13777783 chr17:79615861 NA -0.33 -5.23 -0.31 3.45e-7 Eye color traits; CESC trans rs4650994 0.525 rs4650996 chr1:178517365 A/G cg05059571 chr16:84539110 KIAA1609 -0.4 -6.19 -0.36 2.3e-9 HDL cholesterol levels;HDL cholesterol; CESC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC cis rs7692995 1.000 rs7694806 chr4:18029100 C/T cg08925142 chr4:18023851 LCORL -0.44 -5.2 -0.3 3.92e-7 Height; CESC cis rs7246865 0.954 rs55957788 chr19:17207851 G/A cg19418318 chr19:17219073 MYO9B 0.36 5.9 0.34 1.11e-8 Reticulocyte fraction of red cells; CESC cis rs4604732 0.527 rs79329288 chr1:247626513 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2932538 0.922 rs6659677 chr1:113087076 G/C cg22162597 chr1:113214053 CAPZA1 0.56 7.0 0.39 2.15e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs8070624 0.574 rs11078408 chr17:17876011 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.53 6.69 0.38 1.3100000000000001e-10 Total body bone mineral density; CESC cis rs863345 0.604 rs1157525 chr1:158457253 T/C cg12129480 chr1:158549410 OR10X1 -0.36 -7.15 -0.4 8.67e-12 Pneumococcal bacteremia; CESC cis rs7666738 0.546 rs34159897 chr4:98787367 T/C cg05340658 chr4:99064831 C4orf37 0.58 7.25 0.41 4.5e-12 Colonoscopy-negative controls vs population controls; CESC cis rs60871478 1.000 rs34260834 chr7:822958 A/G cg05535760 chr7:792225 HEATR2 0.85 10.54 0.54 6.54e-22 Cerebrospinal P-tau181p levels; CESC cis rs2576037 0.526 rs564113 chr18:44364389 A/T cg19077165 chr18:44547161 KATNAL2 -0.52 -7.58 -0.42 5.66e-13 Personality dimensions; CESC cis rs644799 0.544 rs555556 chr11:95618425 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.49 6.33 0.36 1.03e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4728302 0.869 rs13221033 chr7:133617487 T/A cg10665199 chr7:133106180 EXOC4 0.39 5.3 0.31 2.49e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs2425143 1.000 rs8124505 chr20:34307247 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -7.59 -0.42 5.42e-13 Blood protein levels; CESC cis rs7799006 0.929 rs6951493 chr7:2257612 G/A cg12745145 chr7:2261452 MAD1L1 -0.38 -5.92 -0.34 1.01e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs7246657 0.943 rs2891699 chr19:37920237 A/G cg01833234 chr11:6592585 DNHD1 0.52 6.0 0.35 6.5e-9 Coronary artery calcification; CESC cis rs10129255 0.500 rs6576232 chr14:107195328 A/G cg23076370 chr14:107095027 NA -0.64 -9.33 -0.5 4.36e-18 Kawasaki disease; CESC cis rs3820068 0.734 rs6669156 chr1:15905206 T/A cg17385448 chr1:15911702 AGMAT 0.43 6.75 0.38 9.27e-11 Systolic blood pressure; CESC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg24250549 chr1:154909240 PMVK -0.63 -8.69 -0.47 3.89e-16 Prostate cancer; CESC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.72 0.47 3.1e-16 Colonoscopy-negative controls vs population controls; CESC trans rs7395662 0.517 rs2021248 chr11:49013054 C/T cg15704280 chr7:45808275 SEPT13 -0.58 -7.1 -0.4 1.11e-11 HDL cholesterol; CESC cis rs7666738 0.830 rs6532701 chr4:98745134 C/T cg03467027 chr4:99064603 C4orf37 0.45 5.53 0.32 7.79e-8 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.817 rs55891651 chr8:58167600 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -8.99 -0.48 4.81e-17 Developmental language disorder (linguistic errors); CESC cis rs11122272 0.735 rs2808596 chr1:231530723 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.78 0.33 2.12e-8 Hemoglobin concentration; CESC cis rs10447248 0.776 rs7444217 chr5:107900097 C/T cg25075504 chr5:107899390 NA -0.39 -5.92 -0.34 9.8e-9 Adiponectin levels; CESC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg12311346 chr5:56204834 C5orf35 -0.64 -8.74 -0.47 2.67e-16 Initial pursuit acceleration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17597374 chr11:61106595 DAK 0.47 6.42 0.37 6.22e-10 Fibrinogen levels; CESC cis rs4975616 0.836 rs13178866 chr5:1323212 C/T cg26373071 chr5:1325741 CLPTM1L 0.42 6.78 0.38 7.64e-11 Lung cancer; CESC cis rs6460942 0.597 rs13221702 chr7:12519076 A/G cg06484146 chr7:12443880 VWDE 0.69 7.5 0.42 9.9e-13 Coronary artery disease; CESC trans rs13394619 0.565 rs12478958 chr2:11748037 A/G cg18984002 chr17:36876514 MLLT6 -0.42 -6.22 -0.36 1.92e-9 Endometriosis; CESC cis rs2235544 0.579 rs1537323 chr1:54482523 G/T cg25741118 chr1:54482237 LDLRAD1 0.22 5.52 0.32 7.91e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs796364 1.000 rs11694369 chr2:200741720 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.94 -7.43 -0.42 1.52e-12 Schizophrenia; CESC cis rs11190604 1.000 rs11190541 chr10:102203071 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs5758659 0.652 rs1063392 chr22:42454950 C/T cg04733989 chr22:42467013 NAGA -0.45 -6.37 -0.36 8.37e-10 Cognitive function; CESC cis rs67311347 1.000 rs1466237 chr3:40462026 C/G cg24209194 chr3:40518798 ZNF619 0.46 6.03 0.35 5.54e-9 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11659435 chr20:30310674 BCL2L1 0.56 6.02 0.35 5.79e-9 Gut microbiome composition (summer); CESC cis rs7246657 1.000 rs12709812 chr19:37794850 A/G cg23950597 chr19:37808831 NA 0.62 6.45 0.37 5.15e-10 Coronary artery calcification; CESC cis rs6565180 1.000 rs12930787 chr16:30381303 C/G cg17640201 chr16:30407289 ZNF48 -0.94 -14.04 -0.65 7.5e-34 Tonsillectomy; CESC trans rs61931739 0.534 rs11052973 chr12:34029708 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.27 0.45 6.34e-15 Morning vs. evening chronotype; CESC cis rs2228479 0.850 rs62054610 chr16:89816920 G/A cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg17376030 chr22:41985996 PMM1 -0.79 -8.37 -0.46 3.43e-15 Vitiligo; CESC cis rs6598955 0.612 rs12738188 chr1:26548029 G/C cg04990556 chr1:26633338 UBXN11 -0.8 -11.48 -0.58 4.98e-25 Obesity-related traits; CESC cis rs4722166 0.630 rs10950916 chr7:22799667 C/T cg05265849 chr7:22767390 IL6 0.55 6.63 0.38 1.86e-10 Lung cancer; CESC cis rs72792276 1.000 rs78529289 chr5:127405378 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 5.5 0.32 8.77e-8 Red cell distribution width; CESC cis rs10242455 0.702 rs28460612 chr7:98993205 C/G cg18809830 chr7:99032528 PTCD1 -0.89 -6.1 -0.35 3.84e-9 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04108570 chr2:9143163 MBOAT2 -0.56 -6.88 -0.39 4.4e-11 Gut microbiome composition (summer); CESC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg04546413 chr19:29218101 NA 0.56 7.77 0.43 1.76e-13 Methadone dose in opioid dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26431313 chr3:151987306 LOC401093;MBNL1 0.55 6.32 0.36 1.11e-9 Gut microbiome composition (summer); CESC cis rs7927771 1.000 rs11039426 chr11:47863119 G/A cg18512352 chr11:47633146 NA -0.6 -9.47 -0.5 1.62e-18 Subjective well-being; CESC cis rs17818399 0.926 rs7590693 chr2:46823992 G/A cg02822958 chr2:46747628 ATP6V1E2 0.48 5.59 0.32 5.57e-8 Height; CESC cis rs698761 0.505 rs7609180 chr2:44538484 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.52 5.29 0.31 2.51e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs4604732 0.603 rs10802512 chr1:247633730 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.58 0.32 6e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs10823500 0.777 rs10509321 chr10:71985733 A/G cg04118878 chr10:71993077 PPA1 -0.51 -6.08 -0.35 4.12e-9 Blood protein levels; CESC cis rs6121246 0.559 rs6121172 chr20:30296095 A/C cg13852791 chr20:30311386 BCL2L1 0.86 11.25 0.57 2.93e-24 Mean corpuscular hemoglobin; CESC cis rs28374715 0.783 rs11630656 chr15:41570909 T/G cg20272979 chr15:41787780 ITPKA 0.42 5.1 0.3 6.53e-7 Ulcerative colitis; CESC cis rs8070128 0.568 rs3935505 chr17:17882020 T/G cg04398451 chr17:18023971 MYO15A -0.65 -8.46 -0.46 1.79e-15 Total body bone mineral density; CESC cis rs4253772 0.637 rs3087501 chr22:46647909 A/G cg09491104 chr22:46646882 C22orf40 -0.56 -8.38 -0.46 3.1e-15 LDL cholesterol;Cholesterol, total; CESC cis rs12220238 0.915 rs7922519 chr10:75976573 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.45 0.32 1.13e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs854765 0.583 rs6502619 chr17:17779704 C/G cg09796270 chr17:17721594 SREBF1 -0.46 -6.46 -0.37 4.99e-10 Total body bone mineral density; CESC cis rs4805272 0.512 rs11879141 chr19:29320335 G/A cg14983838 chr19:29218262 NA 0.44 5.29 0.31 2.57e-7 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs2050392 0.517 rs593400 chr10:30762088 A/G cg18806716 chr10:30721971 MAP3K8 0.49 7.55 0.42 7.25e-13 Inflammatory bowel disease; CESC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg23161317 chr6:28129485 ZNF389 0.49 6.19 0.36 2.28e-9 Parkinson's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21767207 chr19:36236454 PSENEN;U2AF1L4 -0.44 -6.06 -0.35 4.56e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs116095464 0.619 rs2303741 chr5:218356 T/C cg00938859 chr5:1591904 SDHAP3 0.6 6.66 0.38 1.55e-10 Breast cancer; CESC cis rs113835537 0.529 rs2305533 chr11:66298623 A/C cg24851651 chr11:66362959 CCS 0.5 5.96 0.34 8.04e-9 Airway imaging phenotypes; CESC cis rs2760061 0.819 rs708114 chr1:228197496 G/A cg02753203 chr1:228287806 NA 0.53 7.89 0.44 8.14e-14 Diastolic blood pressure; CESC cis rs1451375 0.617 rs2329371 chr7:50615440 G/A cg14593290 chr7:50529359 DDC 0.5 5.98 0.35 7.05e-9 Malaria; CESC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.2 0.4 6.39e-12 Electroencephalogram traits; CESC cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg08704250 chr15:31115839 NA -0.49 -6.61 -0.38 2.09e-10 Huntington's disease progression; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26591553 chr5:176863129 GRK6 0.5 6.74 0.38 9.76e-11 Fibrinogen levels; CESC cis rs5753618 0.504 rs8138525 chr22:32011929 T/C cg00478049 chr22:31556069 RNF185 0.44 5.16 0.3 4.96e-7 Colorectal cancer; CESC cis rs2288912 0.872 rs9304646 chr19:45450408 T/C cg20090143 chr19:45452003 APOC2 0.38 6.49 0.37 4.3e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6088580 0.524 rs6088575 chr20:33273403 C/T cg08999081 chr20:33150536 PIGU 0.37 5.08 0.3 7.16e-7 Glomerular filtration rate (creatinine); CESC cis rs933688 1.000 rs10474353 chr5:90732285 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.17 16.18 0.7 2e-41 Smoking behavior; CESC cis rs933688 1.000 rs6869717 chr5:90694797 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 14.27 0.66 1.16e-34 Smoking behavior; CESC cis rs13242816 0.881 rs35062002 chr7:116142458 G/A cg04696780 chr7:116139425 CAV2 -0.61 -5.55 -0.32 7.01e-8 P wave duration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00173787 chr1:156698861 C1orf66;ISG20L2 0.6 6.94 0.39 2.95e-11 Gut microbiome composition (summer); CESC cis rs3020736 0.500 rs7364293 chr22:42506370 C/T cg12850546 chr22:42539477 CYP2D7P1 0.43 5.16 0.3 4.86e-7 Autism spectrum disorder or schizophrenia; CESC cis rs3806843 0.735 rs801188 chr5:140066916 G/T cg26395211 chr5:140044315 WDR55 0.47 5.94 0.34 9e-9 Depressive symptoms (multi-trait analysis); CESC cis rs10491083 0.661 rs631565 chr17:6568540 T/C cg13067509 chr17:6538498 KIAA0753 0.58 5.13 0.3 5.65e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9916302 0.861 rs752314 chr17:37410700 C/T cg00129232 chr17:37814104 STARD3 -0.55 -7.08 -0.4 1.28e-11 Glomerular filtration rate (creatinine); CESC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.58 8.23 0.45 8.8e-15 Bipolar disorder; CESC cis rs11203032 0.831 rs10887928 chr10:90945861 A/T cg16672925 chr10:90967113 CH25H 0.69 7.02 0.4 1.83e-11 Heart failure; CESC cis rs11249608 0.548 rs6601007 chr5:178455796 G/C cg01312482 chr5:178451176 ZNF879 -0.45 -6.36 -0.36 8.71e-10 Pubertal anthropometrics; CESC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg16325326 chr1:53192061 ZYG11B -0.93 -16.1 -0.7 3.88e-41 Monocyte count; CESC cis rs6032067 0.777 rs62208386 chr20:43790872 G/A cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09556632 chr1:40839764 SMAP2 0.56 6.54 0.37 3.07e-10 Gut microbiome composition (summer); CESC cis rs7546094 1.000 rs7415820 chr1:113169449 G/A cg22162597 chr1:113214053 CAPZA1 -0.39 -6.01 -0.35 6.14e-9 Platelet distribution width; CESC cis rs7336332 0.628 rs9581855 chr13:28018014 G/A cg22138327 chr13:27999177 GTF3A 0.61 5.58 0.32 5.99e-8 Weight; CESC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg04025307 chr7:1156635 C7orf50 0.54 9.55 0.51 8.88e-19 Longevity;Endometriosis; CESC cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg21226059 chr5:178986404 RUFY1 0.49 7.57 0.42 6.27e-13 Lung cancer; CESC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg12963246 chr6:28129442 ZNF389 0.5 6.41 0.37 6.57e-10 Parkinson's disease; CESC cis rs55871839 0.559 rs4737526 chr8:59823372 A/G cg07426533 chr8:59803705 TOX 0.39 5.25 0.31 3.12e-7 Pneumonia; CESC cis rs4974559 0.895 rs12646130 chr4:1330530 G/C cg02980000 chr4:1222292 CTBP1 0.77 7.06 0.4 1.49e-11 Systolic blood pressure; CESC cis rs17253792 0.822 rs78824140 chr14:56042715 G/T cg01858014 chr14:56050164 KTN1 -0.99 -7.46 -0.42 1.21e-12 Putamen volume; CESC cis rs7998202 0.614 rs282571 chr13:113366234 C/G cg02820901 chr13:113351484 ATP11A 0.66 5.74 0.33 2.63e-8 Glycated hemoglobin levels; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg02948236 chr16:66864732 NAE1 -0.44 -6.0 -0.35 6.58e-9 Recombination measurement; CESC cis rs1799949 0.965 rs1842147 chr17:41435192 C/T cg23758822 chr17:41437982 NA 1.03 15.38 0.69 1.41e-38 Menopause (age at onset); CESC cis rs8114671 0.836 rs6142284 chr20:33641367 G/A cg24642439 chr20:33292090 TP53INP2 -0.45 -5.44 -0.32 1.19e-7 Height; CESC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg08736216 chr1:53307985 ZYG11A -0.37 -6.3 -0.36 1.21e-9 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13594432 chr14:23451963 JUB -0.59 -7.05 -0.4 1.58e-11 Gut microbiome composition (summer); CESC cis rs1506636 0.962 rs1506640 chr7:123349627 T/G cg03229431 chr7:123269106 ASB15 -0.52 -6.91 -0.39 3.6e-11 Plateletcrit;Platelet count; CESC cis rs30380 0.553 rs27527 chr5:96151968 C/A cg16492584 chr5:96139282 ERAP1 -0.47 -6.5 -0.37 4.03e-10 Cerebrospinal fluid biomarker levels; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg10057841 chr11:129996244 APLP2 -0.46 -6.3 -0.36 1.21e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6772849 0.896 rs4857859 chr3:128348014 G/T cg16766828 chr3:128327626 NA -0.31 -5.11 -0.3 6.19e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs7917772 0.503 rs11191325 chr10:104302933 G/A cg22532475 chr10:104410764 TRIM8 -0.35 -5.97 -0.34 7.47e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9611565 0.694 rs5751107 chr22:41857812 A/G cg03806693 chr22:41940476 POLR3H 1.19 14.53 0.67 1.37e-35 Vitiligo; CESC cis rs920590 0.758 rs7012358 chr8:19662498 C/T cg03894339 chr8:19674705 INTS10 0.62 7.11 0.4 1.05e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs6991838 0.584 rs4320587 chr8:66499226 G/A cg13398993 chr8:66546079 ARMC1 -0.48 -5.76 -0.33 2.37e-8 Intelligence (multi-trait analysis); CESC cis rs1018836 0.663 rs3950221 chr8:91478108 G/A cg16814680 chr8:91681699 NA -0.58 -7.65 -0.43 3.83e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4862307 0.754 rs6846208 chr4:184991703 C/T cg06737308 chr4:185021514 ENPP6 0.42 5.71 0.33 3.08e-8 Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs826838 0.868 rs12322306 chr12:39130021 A/G cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs77216612 0.877 rs7956514 chr12:12879254 T/G cg09462578 chr12:12878428 APOLD1 -1.0 -15.16 -0.68 7.99e-38 Lymphocyte counts; CESC cis rs731174 0.959 rs7546741 chr1:38191397 G/C cg12339802 chr1:38156545 C1orf109 -0.55 -6.33 -0.36 1.06e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9527 0.590 rs7898770 chr10:104756636 A/G cg04362960 chr10:104952993 NT5C2 -0.41 -5.22 -0.31 3.66e-7 Arsenic metabolism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.2.4963927F chr2:242179805 HDLBP -0.52 -6.22 -0.36 1.94e-9 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.43 0.37 5.82e-10 Bipolar disorder; CESC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg10800226 chr5:1850261 NA 0.32 5.33 0.31 2.15e-7 Cardiovascular disease risk factors; CESC cis rs7523050 0.730 rs11102650 chr1:109464228 C/G cg08274380 chr1:109419600 GPSM2 0.79 5.91 0.34 1.04e-8 Fat distribution (HIV); CESC trans rs1814175 0.647 rs1404157 chr11:49917301 G/C cg15704280 chr7:45808275 SEPT13 -0.82 -11.35 -0.57 1.34e-24 Height; CESC cis rs6754311 0.773 rs4988183 chr2:136622046 T/C cg15123519 chr2:136567270 LCT -0.29 -5.08 -0.3 7.23e-7 Mosquito bite size; CESC cis rs7927592 0.913 rs7109294 chr11:68332093 A/G cg20283391 chr11:68216788 NA -0.61 -7.4 -0.41 1.77e-12 Total body bone mineral density; CESC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.68 0.38 1.36e-10 Bipolar disorder; CESC cis rs2074585 0.679 rs2601195 chr15:90938232 G/A cg22089800 chr15:90895588 ZNF774 0.66 9.16 0.49 1.42e-17 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg10691866 chr7:65817282 TPST1 -0.34 -5.61 -0.33 4.98e-8 Aortic root size; CESC cis rs6866344 0.570 rs59259518 chr5:178142628 C/T cg10224037 chr5:178157518 ZNF354A 0.75 8.67 0.47 4.37e-16 Neutrophil percentage of white cells; CESC cis rs6815814 0.950 rs5743789 chr4:38833173 A/T cg02016764 chr4:38805732 TLR1 -0.61 -6.86 -0.39 4.8e-11 Breast cancer; CESC cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg17366294 chr4:99064904 C4orf37 0.6 8.58 0.47 7.97e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2415984 0.579 rs2817548 chr14:46969149 A/T cg14871534 chr14:47121158 RPL10L 0.35 5.32 0.31 2.21e-7 Number of children ever born; CESC cis rs9399137 0.507 rs4896128 chr6:135349756 A/G cg22676075 chr6:135203613 NA -0.51 -6.92 -0.39 3.34e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs3784262 1.000 rs12908953 chr15:58277812 A/G cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.09 -0.3 6.71e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg13918804 chr1:2043761 PRKCZ 0.28 5.5 0.32 9.09e-8 Height; CESC cis rs12148488 0.763 rs2304902 chr15:75340727 G/T cg14664628 chr15:75095509 CSK -0.46 -5.54 -0.32 7.17e-8 Caffeine consumption; CESC cis rs11792861 0.888 rs11794648 chr9:111829792 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 5.65 0.33 4.11e-8 Menarche (age at onset); CESC cis rs9894429 0.789 rs9747336 chr17:79584189 C/T cg13777783 chr17:79615861 NA -0.33 -5.24 -0.31 3.35e-7 Eye color traits; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12448664 chr15:85143675 ZSCAN2 -0.48 -6.5 -0.37 4.06e-10 Asthma; CESC cis rs11098499 0.818 rs7688802 chr4:120451668 G/A cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.24e-28 Corneal astigmatism; CESC cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.96 0.48 5.78e-17 Age-related macular degeneration (geographic atrophy); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07049977 chr2:37458536 CEBPZ;C2orf56 -0.48 -6.34 -0.36 9.97e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6062302 0.522 rs6090475 chr20:62245397 C/A cg09650180 chr20:62225654 GMEB2 -0.82 -9.38 -0.5 3.04e-18 Glioblastoma; CESC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg18252515 chr7:66147081 NA 0.48 6.47 0.37 4.62e-10 Aortic root size; CESC trans rs1814175 0.817 rs10769641 chr11:49960141 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -20.41 -0.78 2.75e-56 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20018234 chr1:156084659 LMNA 0.55 6.22 0.36 1.88e-9 Gut microbiome composition (summer); CESC cis rs6500395 1.000 rs1106386 chr16:48593065 C/A cg04672837 chr16:48644449 N4BP1 0.5 6.23 0.36 1.78e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1790761 0.587 rs7934075 chr11:67295949 T/C cg00290607 chr11:67383545 NA -0.39 -5.78 -0.33 2.1e-8 Mean corpuscular volume; CESC cis rs6460942 1.000 rs112996286 chr7:12315741 G/C cg20607287 chr7:12443886 VWDE -0.79 -8.51 -0.46 1.32e-15 Coronary artery disease; CESC cis rs12291225 0.546 rs12291662 chr11:14342949 T/C cg19336497 chr11:14380999 RRAS2 -0.45 -6.67 -0.38 1.48e-10 Sense of smell; CESC cis rs847577 0.609 rs11765552 chr7:97822115 T/A cg24562669 chr7:97807699 LMTK2 0.84 13.88 0.65 2.69e-33 Breast cancer; CESC cis rs10751667 0.643 rs10751669 chr11:942344 C/G cg20946044 chr11:1010712 AP2A2 0.42 5.73 0.33 2.78e-8 Alzheimer's disease (late onset); CESC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg27165867 chr14:105738592 BRF1 -0.5 -5.46 -0.32 1.08e-7 Mean platelet volume;Platelet distribution width; CESC cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg15017067 chr4:17643749 FAM184B 0.42 5.98 0.34 7.33e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2276314 0.857 rs7237599 chr18:33639396 T/C cg19628046 chr18:33552617 C18orf21 0.51 5.83 0.34 1.57e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7086627 0.515 rs12245180 chr10:82211897 C/G cg03267442 chr10:82210566 NA -0.34 -5.66 -0.33 3.98e-8 Post bronchodilator FEV1; CESC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg18240062 chr17:79603768 NPLOC4 0.5 6.59 0.38 2.41e-10 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16577540 chr5:139682757 PFDN1 0.62 7.49 0.42 1.06e-12 Gut microbiome composition (summer); CESC cis rs4790333 0.537 rs2447106 chr17:2257819 A/T cg02569219 chr17:2266849 SGSM2 -0.4 -5.36 -0.31 1.84e-7 Proinsulin levels; CESC cis rs2832077 0.689 rs2832052 chr21:30130073 G/C cg08807101 chr21:30365312 RNF160 -0.5 -5.86 -0.34 1.37e-8 Cognitive test performance; CESC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg11764359 chr7:65958608 NA 0.87 13.28 0.63 3.49e-31 Aortic root size; CESC cis rs2463822 0.844 rs1919359 chr11:62055703 A/G cg06239285 chr11:62104954 ASRGL1 1.02 8.67 0.47 4.45e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs6456156 0.586 rs12528689 chr6:167461746 A/G cg07741184 chr6:167504864 NA 0.35 6.08 0.35 4.1e-9 Primary biliary cholangitis; CESC cis rs4141404 0.787 rs11913992 chr22:31585220 G/A cg02404636 chr22:31891804 SFI1 -0.39 -5.61 -0.33 5.05e-8 Paclitaxel-induced neuropathy; CESC cis rs3740713 1.000 rs75487138 chr11:18461878 A/G cg23797887 chr11:18477753 LDHAL6A -0.54 -5.24 -0.31 3.31e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg18758796 chr5:131593413 PDLIM4 0.48 6.97 0.39 2.55e-11 Acylcarnitine levels; CESC cis rs5758659 0.652 rs6519301 chr22:42385967 A/G cg15557168 chr22:42548783 NA -0.44 -6.5 -0.37 4.05e-10 Cognitive function; CESC cis rs1218582 0.688 rs58629129 chr1:154910930 T/C cg06221963 chr1:154839813 KCNN3 -0.59 -9.31 -0.5 5.24e-18 Prostate cancer; CESC cis rs1348850 0.554 rs1374438 chr2:178376684 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.68 6.23 0.36 1.87e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg17971929 chr21:40555470 PSMG1 -0.54 -7.1 -0.4 1.12e-11 Menarche (age at onset); CESC cis rs2249625 0.545 rs2249021 chr6:72889472 A/G cg18830697 chr6:72922368 RIMS1 -0.47 -7.02 -0.4 1.89e-11 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs6449957 0.639 rs831227 chr5:67517646 A/C cg23036683 chr5:67512108 NA 0.41 5.55 0.32 6.82e-8 Cleft lip with or without cleft palate; CESC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg07701084 chr6:150067640 NUP43 0.47 6.72 0.38 1.11e-10 Lung cancer; CESC cis rs6963495 0.818 rs73190187 chr7:105164401 A/T cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg18252515 chr7:66147081 NA 0.47 6.17 0.35 2.57e-9 Aortic root size; CESC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg21963583 chr11:68658836 MRPL21 0.4 5.64 0.33 4.32e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7089973 0.604 rs58587374 chr10:116597572 A/G cg03647239 chr10:116582469 FAM160B1 0.44 5.55 0.32 6.83e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs146201400 1 rs146201400 chr1:26645955 G/GA cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.38 -0.36 7.85e-10 Monocyte percentage of white cells; CESC cis rs16858210 0.874 rs73177525 chr3:183570286 G/C cg25686905 chr3:183603175 PARL -0.33 -6.21 -0.36 2.04e-9 Menopause (age at onset); CESC cis rs9916302 0.821 rs4795386 chr17:37746847 A/G cg00129232 chr17:37814104 STARD3 -0.69 -9.03 -0.49 3.68e-17 Glomerular filtration rate (creatinine); CESC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg13393036 chr8:95962371 TP53INP1 -0.48 -10.27 -0.53 4.94e-21 Type 2 diabetes; CESC cis rs1153858 1.000 rs12437887 chr15:45669094 G/A cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs916888 0.821 rs199507 chr17:44858855 A/G cg01570182 chr17:44337453 NA -0.87 -10.59 -0.55 4.47e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs13095912 0.638 rs6791369 chr3:185289989 C/A cg11274856 chr3:185301563 NA 0.37 5.47 0.32 1.06e-7 Systolic blood pressure; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg24714709 chr7:95064397 PON2 -0.46 -6.17 -0.35 2.6e-9 Recombination measurement; CESC cis rs4555082 0.957 rs10140586 chr14:105749582 A/G cg13114125 chr14:105738426 BRF1 -0.71 -8.91 -0.48 8.36e-17 Mean platelet volume;Platelet distribution width; CESC cis rs7246657 0.943 rs4803347 chr19:37848017 G/A cg23950597 chr19:37808831 NA -0.54 -5.94 -0.34 9.05e-9 Coronary artery calcification; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21209604 chr6:26032199 HIST1H3B 0.55 6.45 0.37 5.26e-10 Gut microbiome composition (summer); CESC cis rs4563143 0.514 rs55727361 chr19:29300415 A/T cg14983838 chr19:29218262 NA 0.49 5.45 0.32 1.15e-7 Methadone dose in opioid dependence; CESC cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs977987 0.843 rs2059256 chr16:75395835 G/T cg03315344 chr16:75512273 CHST6 0.39 5.61 0.33 4.98e-8 Dupuytren's disease; CESC cis rs1046896 0.562 rs2380172 chr17:80887719 C/A cg19046167 chr17:80928561 B3GNTL1 0.51 6.24 0.36 1.75e-9 Glycated hemoglobin levels; CESC cis rs56046484 0.956 rs34076898 chr15:85664800 A/C cg08123816 chr15:85640762 PDE8A -0.5 -6.19 -0.36 2.23e-9 Testicular germ cell tumor; CESC cis rs1728785 1.000 rs698717 chr16:68560199 A/G cg02972257 chr16:68554789 NA -0.62 -6.95 -0.39 2.75e-11 Ulcerative colitis; CESC cis rs9479482 1.000 rs9479403 chr6:150337746 C/T cg03788504 chr6:150331562 NA 0.36 6.89 0.39 4.06e-11 Alopecia areata; CESC trans rs66573146 0.572 rs67252699 chr4:6946411 A/G cg07817883 chr1:32538562 TMEM39B 1.25 8.66 0.47 4.59e-16 Granulocyte percentage of myeloid white cells; CESC cis rs10857712 0.703 rs1056521 chr10:135235890 T/C cg22671611 chr10:135291010 NA -0.34 -5.08 -0.3 7.11e-7 Systemic lupus erythematosus; CESC cis rs6756513 0.509 rs11686934 chr2:70172116 C/T cg02498382 chr2:70120550 SNRNP27 0.31 5.22 0.31 3.64e-7 Breast cancer;Platelet count; CESC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg19748678 chr4:122722346 EXOSC9 0.78 9.68 0.51 3.7e-19 Type 2 diabetes; CESC cis rs9913156 0.793 rs55782417 chr17:4562845 G/A cg19197139 chr17:4613644 ARRB2 0.92 10.46 0.54 1.18e-21 Lymphocyte counts; CESC cis rs12477438 0.501 rs12992218 chr2:99753834 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.81 0.7 4.17e-40 Chronic sinus infection; CESC cis rs593982 0.920 rs645621 chr11:65490756 T/C cg08755490 chr11:65554678 OVOL1 1.2 10.9 0.56 4.29e-23 Atopic dermatitis; CESC cis rs1062177 1.000 rs2964578 chr5:151147198 T/A cg00977110 chr5:151150581 G3BP1 0.68 7.31 0.41 3.09e-12 Preschool internalizing problems; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg04915975 chr3:139063070 MRPS22 -0.5 -6.02 -0.35 5.71e-9 Lung cancer in ever smokers; CESC trans rs1838564 0.929 rs805510 chr12:28139846 C/T cg11798959 chr1:23857321 E2F2 0.65 6.22 0.36 1.94e-9 Breast size; CESC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg18337363 chr3:52569053 NT5DC2 0.29 5.25 0.31 3.11e-7 Intelligence (multi-trait analysis); CESC cis rs7539624 0.588 rs7414311 chr1:223901497 A/G cg10100437 chr1:223903862 CAPN2 0.44 5.64 0.33 4.3e-8 Schizophrenia; CESC trans rs4295623 0.585 rs13259242 chr8:11593033 T/G cg15556689 chr8:8085844 FLJ10661 -0.55 -6.32 -0.36 1.11e-9 Morning vs. evening chronotype; CESC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.64 -8.23 -0.45 8.51e-15 Tonsillectomy; CESC cis rs5769765 0.825 rs9616780 chr22:50292763 T/C cg26441486 chr22:50317300 CRELD2 0.39 5.37 0.31 1.76e-7 Schizophrenia; CESC cis rs4604732 0.536 rs76191272 chr1:247628055 A/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 6.01 0.35 6.07e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9815354 0.904 rs9852991 chr3:41875455 C/A cg03022575 chr3:42003672 ULK4 0.58 6.01 0.35 5.96e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs17666538 0.585 rs4448252 chr8:615597 A/G cg23958373 chr8:599963 NA 0.81 6.0 0.35 6.49e-9 IgG glycosylation; CESC cis rs41271473 0.526 rs10916344 chr1:228737489 C/T cg16512390 chr1:228756714 NA 0.55 5.66 0.33 3.84e-8 Chronic lymphocytic leukemia; CESC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -6.72 -0.38 1.08e-10 Bipolar disorder; CESC cis rs2760061 0.626 rs634106 chr1:228121548 C/T cg02753203 chr1:228287806 NA -0.49 -7.38 -0.41 2.06e-12 Diastolic blood pressure; CESC trans rs61931739 0.500 rs10844845 chr12:34381117 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.33 0.41 2.75e-12 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02979170 chr11:118972138 DPAGT1 -0.58 -6.09 -0.35 3.98e-9 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.95e-9 Extrinsic epigenetic age acceleration; CESC cis rs2228479 0.702 rs62056100 chr16:89939753 C/T cg06558623 chr16:89946397 TCF25 1.15 8.93 0.48 7.22e-17 Skin colour saturation; CESC trans rs61931739 0.500 rs11053223 chr12:34481947 T/A cg26384229 chr12:38710491 ALG10B 0.7 10.6 0.55 4.1e-22 Morning vs. evening chronotype; CESC cis rs796364 0.906 rs6740981 chr2:201060216 T/C cg23649088 chr2:200775458 C2orf69 0.5 5.21 0.3 3.84e-7 Schizophrenia; CESC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -7.03 -0.4 1.8e-11 Extrinsic epigenetic age acceleration; CESC cis rs867529 0.695 rs335124 chr2:89052026 A/G cg26627705 chr2:89060884 NA 0.4 5.44 0.32 1.21e-7 Height; CESC cis rs7666738 0.830 rs1456208 chr4:98678563 C/T cg17366294 chr4:99064904 C4orf37 0.55 7.36 0.41 2.26e-12 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.558 rs7710005 chr5:233572 A/G cg22857025 chr5:266934 NA -1.27 -17.86 -0.74 2.25e-47 Breast cancer; CESC cis rs3733585 0.673 rs116046986 chr4:9957794 A/G cg11266682 chr4:10021025 SLC2A9 -0.59 -11.01 -0.56 1.79e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2996428 0.601 rs59414187 chr1:3762815 T/C cg13057898 chr1:3703894 LRRC47 0.45 6.12 0.35 3.33e-9 Red cell distribution width; CESC cis rs735396 0.770 rs2257764 chr12:121446446 T/A cg25281562 chr12:121454272 C12orf43 -0.5 -6.2 -0.36 2.16e-9 N-glycan levels; CESC cis rs10129255 0.518 rs2006284 chr14:107132201 G/A cg23076370 chr14:107095027 NA -0.64 -9.86 -0.52 1e-19 Kawasaki disease; CESC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg03188948 chr7:1209495 NA 0.77 7.71 0.43 2.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11677370 0.561 rs4849990 chr2:3819558 A/G cg17052675 chr2:3827356 NA -0.4 -5.23 -0.31 3.44e-7 Type 2 diabetes; CESC cis rs57506017 0.585 rs5011438 chr7:12268798 C/T cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.62e-7 Neuroticism; CESC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.44 0.32 1.2e-7 Personality dimensions; CESC cis rs1843834 0.539 rs6713629 chr2:225410973 A/T cg12698349 chr2:225449008 CUL3 0.62 8.88 0.48 1.03e-16 IgE levels in asthmatics (D.p. specific); CESC cis rs3096299 0.802 rs3102336 chr16:89442006 C/T cg08822215 chr16:89438651 ANKRD11 -0.46 -7.32 -0.41 2.98e-12 Multiple myeloma (IgH translocation); CESC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg17747265 chr1:1875780 NA -0.6 -9.81 -0.52 1.42e-19 Body mass index; CESC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg22143856 chr6:28129313 ZNF389 -0.52 -6.68 -0.38 1.38e-10 Depression; CESC cis rs9911578 1.000 rs2567911 chr17:56734977 A/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC cis rs6840258 1.000 rs767315 chr4:87960435 C/T cg08197287 chr4:87952173 AFF1 -0.38 -5.21 -0.3 3.77e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24792749 chr19:33166123 ANKRD27;RGS9BP 0.47 6.1 0.35 3.65e-9 Gut microbiota (bacterial taxa); CESC cis rs589448 0.538 rs683790 chr12:69751434 T/G cg20891283 chr12:69753455 YEATS4 0.76 10.05 0.53 2.45e-20 Cerebrospinal fluid biomarker levels; CESC cis rs11098499 0.909 rs79026312 chr4:120440677 C/A cg24375607 chr4:120327624 NA 0.44 5.27 0.31 2.85e-7 Corneal astigmatism; CESC cis rs12950390 0.814 rs4794099 chr17:45838358 T/C cg00777063 chr17:45855553 NA -0.41 -6.12 -0.35 3.4e-9 IgG glycosylation; CESC cis rs6088580 0.608 rs2105109 chr20:32971932 A/G cg08999081 chr20:33150536 PIGU -0.66 -11.72 -0.58 8.03e-26 Glomerular filtration rate (creatinine); CESC cis rs55883249 1.000 rs55883249 chr2:9741535 C/A cg23886495 chr2:9695866 ADAM17 0.61 5.55 0.32 7.08e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg26314531 chr2:26401878 FAM59B 0.85 9.03 0.49 3.58e-17 Gut microbiome composition (summer); CESC cis rs9287719 0.967 rs4555318 chr2:10744295 C/G cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg11644478 chr21:40555479 PSMG1 0.97 14.14 0.66 3.2e-34 Cognitive function; CESC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg18876405 chr7:65276391 NA 0.5 5.89 0.34 1.16e-8 Aortic root size; CESC cis rs2408955 0.561 rs9971924 chr12:48479832 C/G cg24011408 chr12:48396354 COL2A1 -0.49 -7.34 -0.41 2.55e-12 Glycated hemoglobin levels; CESC cis rs4654899 0.865 rs61779120 chr1:21481230 T/C cg05370193 chr1:21551575 ECE1 0.46 7.03 0.4 1.79e-11 Superior frontal gyrus grey matter volume; CESC cis rs7116495 1.000 rs2508858 chr11:71805405 C/G cg10381502 chr11:71823885 C11orf51 0.65 5.3 0.31 2.39e-7 Severe influenza A (H1N1) infection; CESC cis rs4595586 0.545 rs7967295 chr12:39376866 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg01783706 chr12:49739991 DNAJC22 0.46 6.26 0.36 1.53e-9 Thyroid stimulating hormone; CESC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.54 -0.32 7.38e-8 Huntington's disease progression; CESC cis rs2073300 1.000 rs6137977 chr20:23464191 G/T cg12062639 chr20:23401060 NAPB 0.92 6.06 0.35 4.62e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2235544 1.000 rs2235544 chr1:54375570 A/C cg25741118 chr1:54482237 LDLRAD1 -0.2 -5.32 -0.31 2.17e-7 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg06505273 chr16:24850292 NA -0.53 -6.49 -0.37 4.27e-10 Intelligence (multi-trait analysis); CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.41 8.05 0.44 2.86e-14 Hemoglobin concentration; CESC cis rs72634258 0.891 rs404381 chr1:8080745 C/T cg00042356 chr1:8021962 PARK7 0.45 5.2 0.3 4.01e-7 Inflammatory bowel disease; CESC cis rs8060686 0.516 rs13339471 chr16:68253008 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -7.32 -0.41 2.95e-12 HDL cholesterol;Metabolic syndrome; CESC cis rs11190604 1.000 rs10883510 chr10:102297018 C/T cg07080220 chr10:102295463 HIF1AN 0.66 6.04 0.35 5.32e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs4975709 0.569 rs2353583 chr5:1858834 G/C cg15595755 chr5:1867978 NA 0.51 8.11 0.45 1.92e-14 Cardiovascular disease risk factors; CESC cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg16339924 chr4:17578868 LAP3 0.85 10.87 0.56 5.49e-23 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg21138405 chr5:131827807 IRF1 -0.57 -9.83 -0.52 1.17e-19 Asthma (sex interaction); CESC cis rs6060717 0.654 rs6058347 chr20:34483781 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -9.27 -0.49 6.63e-18 Hip circumference adjusted for BMI; CESC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -7.05 -0.4 1.56e-11 Bipolar disorder; CESC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs3820928 0.874 rs4675130 chr2:227827740 G/T cg11843606 chr2:227700838 RHBDD1 -0.43 -5.54 -0.32 7.3900000000000007e-08 Pulmonary function; CESC cis rs2072732 0.898 rs2981856 chr1:2972524 T/C cg03976712 chr1:2946727 NA 0.3 5.13 0.3 5.66e-7 Plateletcrit; CESC cis rs6456156 0.586 rs13208636 chr6:167461965 T/G cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.13e-10 Primary biliary cholangitis; CESC cis rs7116495 0.609 rs73531955 chr11:71687794 A/C cg26138937 chr11:71823887 C11orf51 1.27 8.02 0.44 3.5e-14 Severe influenza A (H1N1) infection; CESC cis rs1707322 1.000 rs785497 chr1:46591903 G/C cg05343316 chr1:45956843 TESK2 -0.47 -5.52 -0.32 7.97e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9399401 0.633 rs262118 chr6:142843054 C/A cg03128060 chr6:142623767 GPR126 0.41 6.79 0.38 7.49e-11 Chronic obstructive pulmonary disease; CESC cis rs7089973 0.604 rs2420065 chr10:116583753 A/G cg23260525 chr10:116636907 FAM160B1 0.38 6.86 0.39 4.82e-11 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs250677 0.687 rs36046 chr5:148441257 A/C cg18129178 chr5:148520854 ABLIM3 -0.52 -5.94 -0.34 8.76e-9 Breast cancer; CESC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg27286337 chr10:134555280 INPP5A 0.69 8.15 0.45 1.43e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2050392 0.517 rs602097 chr10:30747546 C/T cg25182066 chr10:30743637 MAP3K8 -0.55 -8.13 -0.45 1.69e-14 Inflammatory bowel disease; CESC cis rs4849845 0.637 rs13022486 chr2:121038611 C/T cg24070213 chr2:121070622 NA 0.43 6.32 0.36 1.07e-9 Mean platelet volume; CESC cis rs9457247 1.000 rs386548 chr6:167385533 A/T cg23791538 chr6:167370224 RNASET2 0.61 8.67 0.47 4.34e-16 Crohn's disease; CESC cis rs5743618 0.537 rs28413898 chr4:38768669 A/G cg02016764 chr4:38805732 TLR1 -0.32 -5.05 -0.3 8.36e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg25072359 chr17:41440525 NA -0.5 -7.37 -0.41 2.13e-12 Menopause (age at onset); CESC cis rs7539542 0.556 rs4950888 chr1:202872625 C/T cg19681188 chr1:202830198 LOC148709 0.41 5.17 0.3 4.73e-7 Mean platelet volume; CESC cis rs524281 0.692 rs2254388 chr11:65837599 C/T cg14036092 chr11:66035641 RAB1B 0.51 5.61 0.33 5.13e-8 Electroencephalogram traits; CESC cis rs9916302 0.904 rs9894500 chr17:37515735 G/C cg07936489 chr17:37558343 FBXL20 0.78 10.7 0.55 1.93e-22 Glomerular filtration rate (creatinine); CESC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.5 0.37 3.9e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2235544 0.565 rs633315 chr1:54468689 G/A cg25741118 chr1:54482237 LDLRAD1 0.24 5.77 0.33 2.2e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs2625529 0.938 rs8747 chr15:72115541 C/A cg16672083 chr15:72433130 SENP8 -0.45 -5.54 -0.32 7.16e-8 Red blood cell count; CESC cis rs6582630 0.502 rs1115515 chr12:38279830 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.04 0.35 5.23e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs11657217 0.677 rs8071194 chr17:77698458 A/C cg06901238 chr17:77706717 ENPP7 0.42 6.15 0.35 2.82e-9 Diastolic blood pressure response to hydrochlorothiazide in hypertension; CESC cis rs559928 0.606 rs11231726 chr11:63987339 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 5.55 0.32 6.81e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs4851870 1.000 rs12997041 chr2:106444338 T/C cg16077055 chr2:106428750 NCK2 -0.39 -5.04 -0.3 8.58e-7 Addiction; CESC cis rs7219021 0.926 rs10468517 chr17:46862114 C/T cg16584676 chr17:46985605 UBE2Z -0.56 -6.44 -0.37 5.45e-10 Schizophrenia or bipolar disorder; CESC cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg10523679 chr1:76189770 ACADM 0.8 11.03 0.56 1.58e-23 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6541297 1.000 rs1998065 chr1:230286647 T/G cg20703242 chr1:230279135 GALNT2 0.74 11.07 0.56 1.18e-23 Coronary artery disease; CESC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg22903471 chr2:27725779 GCKR -0.55 -7.77 -0.43 1.69e-13 Total body bone mineral density; CESC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.82 11.66 0.58 1.2e-25 Alzheimer's disease; CESC cis rs9906944 0.585 rs11650936 chr17:47072261 C/G cg16584676 chr17:46985605 UBE2Z 0.44 5.39 0.31 1.56e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg04414720 chr1:150670196 GOLPH3L -0.51 -6.69 -0.38 1.36e-10 Melanoma; CESC cis rs3741151 1.000 rs1892855 chr11:73017972 G/T cg17517138 chr11:73019481 ARHGEF17 1.13 7.47 0.42 1.15e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs722599 0.683 rs8022046 chr14:75278302 G/A cg08847533 chr14:75593920 NEK9 0.49 5.9 0.34 1.13e-8 IgG glycosylation; CESC cis rs7647973 0.696 rs7100 chr3:49053219 A/G cg06212747 chr3:49208901 KLHDC8B 0.48 5.34 0.31 2.02e-7 Menarche (age at onset); CESC cis rs9388451 0.807 rs1268065 chr6:126042783 G/A cg05901451 chr6:126070800 HEY2 0.6 8.71 0.47 3.43e-16 Brugada syndrome; CESC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.42 -5.4 -0.31 1.51e-7 Tonsillectomy; CESC cis rs57502260 0.704 rs55975204 chr11:68249124 C/T cg20283391 chr11:68216788 NA -0.66 -5.48 -0.32 1.01e-7 Total body bone mineral density (age 45-60); CESC cis rs897984 0.574 rs11647284 chr16:31077335 G/A cg02466173 chr16:30829666 NA -0.45 -7.6 -0.42 5.05e-13 Dementia with Lewy bodies; CESC cis rs7267979 1.000 rs447722 chr20:25443510 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.57 0.73 2.33e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs8141529 0.748 rs132528 chr22:29295898 C/T cg15103426 chr22:29168792 CCDC117 -0.61 -7.9 -0.44 7.4e-14 Lymphocyte counts; CESC cis rs4523957 0.928 rs7213232 chr17:2165340 A/G cg16513277 chr17:2031491 SMG6 -0.58 -7.86 -0.43 9.46e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs73568641 0.669 rs73568685 chr6:154049469 A/G cg08374472 chr16:87445639 ZCCHC14 -0.49 -6.3 -0.36 1.25e-9 Methadone dose in opioid dependence; CESC cis rs11122272 0.735 rs11122280 chr1:231519816 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.05 0.35 4.97e-9 Hemoglobin concentration; CESC cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -7.6 -0.42 5.23e-13 Alzheimer's disease; CESC cis rs3540 0.533 rs4932342 chr15:90982923 C/T cg10434728 chr15:90938212 IQGAP1 0.41 7.32 0.41 2.99e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs400736 0.800 rs225095 chr1:8102801 T/C cg25007680 chr1:8021821 PARK7 0.71 9.97 0.52 4.51e-20 Response to antidepressants and depression; CESC trans rs17685 0.753 rs11764129 chr7:75761890 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 12.41 0.61 3.51e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs9443645 0.527 rs10943608 chr6:79674929 T/C cg05283184 chr6:79620031 NA -0.36 -5.26 -0.31 2.96e-7 Intelligence (multi-trait analysis); CESC cis rs896854 0.517 rs896851 chr8:95950251 T/C cg09323728 chr8:95962352 TP53INP1 -0.33 -6.0 -0.35 6.34e-9 Type 2 diabetes; CESC cis rs11252926 0.507 rs4881199 chr10:428090 C/G cg18196295 chr10:418757 DIP2C 0.53 7.32 0.41 3e-12 Psychosis in Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05897255 chr7:149535402 ZNF862 0.55 6.44 0.37 5.71e-10 Gut microbiome composition (summer); CESC cis rs4888262 0.508 rs4887779 chr16:74647795 A/G cg01733217 chr16:74700730 RFWD3 -0.87 -12.4 -0.61 3.82e-28 Testicular germ cell tumor; CESC cis rs854765 0.583 rs9908832 chr17:17871068 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 6.05 0.35 4.85e-9 Total body bone mineral density; CESC cis rs992157 1.000 rs992157 chr2:219154781 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.73 -10.25 -0.53 5.65e-21 Colorectal cancer; CESC cis rs6963495 0.872 rs73190193 chr7:105164852 A/G cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg11764359 chr7:65958608 NA 0.81 11.74 0.58 6.73e-26 Aortic root size; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg07781247 chr5:93954443 ANKRD32;C5orf36 0.46 6.01 0.35 6.18e-9 Thyroid stimulating hormone; CESC cis rs7772486 0.875 rs2814874 chr6:146305895 C/T cg05347473 chr6:146136440 FBXO30 0.56 7.37 0.41 2.14e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg21770322 chr7:97807741 LMTK2 -0.65 -9.31 -0.5 5.23e-18 Prostate cancer (SNP x SNP interaction); CESC cis rs7267979 1.000 rs2184000 chr20:25395878 G/A cg08601574 chr20:25228251 PYGB -0.37 -5.37 -0.31 1.76e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs787274 0.867 rs2798316 chr9:115462552 T/C cg13803584 chr9:115635662 SNX30 0.52 5.04 0.3 8.51e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg17372223 chr3:52568218 NT5DC2 0.42 6.45 0.37 5.43e-10 Electroencephalogram traits; CESC cis rs9660992 0.547 rs12143121 chr1:205199142 A/G cg00857998 chr1:205179979 DSTYK 0.55 6.81 0.39 6.65e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg06544989 chr22:39130855 UNC84B -0.49 -8.3 -0.45 5.47e-15 Menopause (age at onset); CESC cis rs5769765 1.000 rs5769760 chr22:50259696 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.45 5.22 0.31 3.61e-7 Schizophrenia; CESC cis rs11031096 0.502 rs7935824 chr11:4046900 C/G cg18678763 chr11:4115507 RRM1 -0.42 -5.59 -0.33 5.51e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs1182196 0.502 rs757786 chr7:2836019 C/T cg18446336 chr7:2847575 GNA12 -0.38 -6.46 -0.37 4.87e-10 Plateletcrit; CESC cis rs524023 1.000 rs537246 chr11:64360630 G/A cg07220939 chr11:64358617 SLC22A12 0.36 5.59 0.32 5.66e-8 Urate levels in obese individuals; CESC cis rs9837602 0.810 rs35777905 chr3:99690970 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 5.05 0.3 8.29e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23979971 chr5:138677953 PAIP2 0.62 7.23 0.41 5.14e-12 Gut microbiome composition (summer); CESC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg03806693 chr22:41940476 POLR3H -1.16 -16.25 -0.71 1.17e-41 Vitiligo; CESC trans rs17508449 0.865 rs4839330 chr1:114137582 T/C cg23028848 chr11:57092561 TNKS1BP1 -0.79 -6.26 -0.36 1.54e-9 Leprosy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05018671 chr8:27146760 TRIM35 -0.56 -6.69 -0.38 1.34e-10 Gut microbiome composition (summer); CESC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg13393036 chr8:95962371 TP53INP1 -0.55 -12.45 -0.61 2.54e-28 Type 2 diabetes; CESC cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg20848291 chr7:100343083 ZAN -0.64 -6.73 -0.38 1.02e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2404602 0.692 rs59088060 chr15:76859974 T/C cg26408565 chr15:76604113 ETFA -0.4 -5.72 -0.33 2.92e-8 Blood metabolite levels; CESC cis rs920590 0.721 rs61180388 chr8:19670214 G/C cg17834443 chr8:19674713 INTS10 0.59 6.49 0.37 4.11e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs8114671 1.000 rs8114671 chr20:33789142 C/A cg06115741 chr20:33292138 TP53INP2 -0.42 -5.11 -0.3 6.06e-7 Height; CESC cis rs72945132 0.882 rs6592552 chr11:70223831 A/T cg00319359 chr11:70116639 PPFIA1 0.72 7.04 0.4 1.64e-11 Coronary artery disease; CESC cis rs7100689 0.646 rs2486302 chr10:82076600 G/A cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 4.91e-14 Post bronchodilator FEV1; CESC trans rs2121875 0.667 rs55676975 chr5:44220818 C/T cg07292773 chr6:156718177 NA -0.47 -6.01 -0.35 6.16e-9 Prostate cancer; CESC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg02896835 chr1:92012615 NA 0.45 5.48 0.32 9.97e-8 Breast cancer; CESC cis rs9911578 0.967 rs6416932 chr17:57148991 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.41 5.33 0.31 2.1e-7 Intelligence (multi-trait analysis); CESC cis rs9929218 0.954 rs12596834 chr16:68823199 T/C cg02972257 chr16:68554789 NA 0.45 5.39 0.31 1.58e-7 Colorectal cancer; CESC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg20891558 chr2:74357851 NA 0.83 12.1 0.6 3.84e-27 Gestational age at birth (maternal effect); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09414045 chr1:110162465 AMPD2 -0.44 -6.09 -0.35 3.93e-9 Fibrinogen levels; CESC cis rs733592 0.524 rs10875744 chr12:48498440 G/C cg04545296 chr12:48745243 ZNF641 0.29 5.33 0.31 2.15e-7 Plateletcrit; CESC cis rs2739330 0.892 rs5751776 chr22:24266954 A/C cg04234412 chr22:24373322 LOC391322 -0.58 -8.51 -0.46 1.33e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9911578 0.967 rs8075786 chr17:56819216 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.21 0.3 3.88e-7 Intelligence (multi-trait analysis); CESC trans rs2099077 0.867 rs12110237 chr5:102796072 A/G cg07434438 chr16:72961899 ZFHX3 0.5 6.77 0.38 8.2e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg25036284 chr2:26402008 FAM59B -0.59 -6.9 -0.39 3.85e-11 Gut microbiome composition (summer); CESC cis rs9715521 0.677 rs67500083 chr4:59862419 C/T cg11281224 chr4:60001000 NA -0.56 -7.73 -0.43 2.24e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7945705 0.967 rs7123861 chr11:8892323 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.5 7.94 0.44 5.61e-14 Hemoglobin concentration; CESC cis rs1153858 1.000 rs1554521 chr15:45664189 A/T cg21132104 chr15:45694354 SPATA5L1 -0.85 -11.49 -0.58 4.47e-25 Homoarginine levels; CESC cis rs9527 0.590 rs10883829 chr10:104840635 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.61 0.33 4.99e-8 Arsenic metabolism; CESC cis rs2228479 0.850 rs34033205 chr16:89922959 G/T cg06558623 chr16:89946397 TCF25 1.2 9.14 0.49 1.65e-17 Skin colour saturation; CESC cis rs12449964 0.524 rs4925094 chr17:17569012 C/T cg04398451 chr17:18023971 MYO15A 0.39 5.38 0.31 1.62e-7 Coronary artery disease or ischemic stroke; CESC cis rs9443645 0.527 rs949846 chr6:79817596 C/T cg05283184 chr6:79620031 NA -0.36 -5.22 -0.31 3.53e-7 Intelligence (multi-trait analysis); CESC cis rs7116495 0.609 rs1892920 chr11:71702431 A/G cg26138937 chr11:71823887 C11orf51 -1.26 -8.25 -0.45 7.58e-15 Severe influenza A (H1N1) infection; CESC cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg24829409 chr8:58192753 C8orf71 -0.48 -5.8 -0.34 1.84e-8 Developmental language disorder (linguistic errors); CESC cis rs7586879 0.681 rs6756609 chr2:25121125 C/A cg01884057 chr2:25150051 NA 0.36 6.91 0.39 3.66e-11 Body mass index; CESC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg11644478 chr21:40555479 PSMG1 -0.52 -6.96 -0.39 2.69e-11 Menarche (age at onset); CESC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg17971929 chr21:40555470 PSMG1 -0.84 -12.15 -0.6 2.64e-27 Cognitive function; CESC cis rs9300255 0.602 rs1790131 chr12:123701010 G/T cg00376283 chr12:123451042 ABCB9 0.7 8.83 0.48 1.45e-16 Neutrophil percentage of white cells; CESC cis rs8028182 0.636 rs4886716 chr15:75856022 G/C cg20655648 chr15:75932815 IMP3 0.48 5.88 0.34 1.23e-8 Sudden cardiac arrest; CESC cis rs10463316 0.894 rs954339 chr5:150752161 C/A cg03212797 chr5:150827313 SLC36A1 -0.42 -5.41 -0.32 1.41e-7 Metabolite levels (Pyroglutamine); CESC cis rs896543 0.702 rs6711119 chr2:237494334 C/T cg25295825 chr2:237489920 CXCR7 0.7 8.86 0.48 1.22e-16 Alcohol dependence (age at onset); CESC cis rs9486719 1.000 rs4343922 chr6:96876903 C/T cg18709589 chr6:96969512 KIAA0776 0.49 5.58 0.32 5.81e-8 Migraine;Coronary artery disease; CESC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg06456125 chr7:65229604 NA 0.44 5.84 0.34 1.56e-8 Aortic root size; CESC cis rs7809950 0.678 rs3801966 chr7:106824580 G/A cg23024343 chr7:107201750 COG5 -0.58 -6.51 -0.37 3.74e-10 Coronary artery disease; CESC cis rs3820068 0.734 rs6669156 chr1:15905206 T/A cg18192808 chr1:15853278 DNAJC16 0.43 5.19 0.3 4.23e-7 Systolic blood pressure; CESC cis rs12431939 1.000 rs67065973 chr14:51656225 T/C cg23942311 chr14:51606299 NA -0.41 -5.09 -0.3 6.8e-7 Cancer; CESC cis rs10504229 0.593 rs58647001 chr8:58025132 G/A cg22535103 chr8:58192502 C8orf71 -0.56 -6.35 -0.36 9.45e-10 Developmental language disorder (linguistic errors); CESC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg11859384 chr17:80120422 CCDC57 0.4 5.5 0.32 8.88e-8 Life satisfaction; CESC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg03806693 chr22:41940476 POLR3H -1.19 -13.62 -0.64 2.26e-32 Vitiligo; CESC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -10.95 -0.56 2.97e-23 Extrinsic epigenetic age acceleration; CESC cis rs3820068 0.734 rs6674806 chr1:15902656 A/G cg17385448 chr1:15911702 AGMAT 0.4 6.22 0.36 1.89e-9 Systolic blood pressure; CESC cis rs16973500 0.711 rs72801789 chr16:71959748 C/T cg09427745 chr16:71932006 KIAA0174 -0.5 -5.14 -0.3 5.27e-7 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs1005277 0.505 rs13503 chr10:38239843 C/A cg25517755 chr10:38738941 LOC399744 0.39 5.04 0.3 8.55e-7 Extrinsic epigenetic age acceleration; CESC cis rs4319547 0.688 rs6489158 chr12:123110365 T/G cg05707623 chr12:122985044 ZCCHC8 -0.42 -5.18 -0.3 4.35e-7 Body mass index; CESC cis rs9399135 0.935 rs11759999 chr6:135370495 G/T cg22676075 chr6:135203613 NA 0.52 7.31 0.41 3.17e-12 Red blood cell count; CESC cis rs61931739 0.534 rs10506120 chr12:34235603 G/A cg19457237 chr12:34500585 NA -0.38 -5.29 -0.31 2.52e-7 Morning vs. evening chronotype; CESC cis rs17253792 0.822 rs76201070 chr14:56063604 A/C cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs8141529 1.000 rs132534 chr22:29299806 T/C cg15103426 chr22:29168792 CCDC117 -0.52 -6.12 -0.35 3.36e-9 Lymphocyte counts; CESC cis rs3733585 0.673 rs4292333 chr4:9953871 G/A cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9911578 0.803 rs8069033 chr17:57131581 T/A cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -5.09 -0.3 6.91e-7 Intelligence (multi-trait analysis); CESC cis rs2425143 1.000 rs56116518 chr20:34286251 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -7.38 -0.41 2.07e-12 Blood protein levels; CESC cis rs2380220 0.678 rs4308568 chr6:96009525 A/C cg04719120 chr6:96025338 MANEA -0.52 -5.75 -0.33 2.45e-8 Behavioural disinhibition (generation interaction); CESC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg07677032 chr17:61819896 STRADA 0.45 5.65 0.33 4.13e-8 Height; CESC cis rs6496667 0.533 rs7172909 chr15:90991416 C/T cg22089800 chr15:90895588 ZNF774 0.45 5.81 0.34 1.75e-8 Rheumatoid arthritis; CESC cis rs6674970 1.000 rs6674970 chr1:151116279 C/T cg11822372 chr1:151115635 SEMA6C 0.47 6.86 0.39 4.78e-11 Childhood ear infection; CESC cis rs2075371 0.932 rs1862048 chr7:133978167 C/G cg20476274 chr7:133979776 SLC35B4 -0.79 -10.17 -0.53 1e-20 Mean platelet volume; CESC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg04166393 chr7:2884313 GNA12 0.62 8.07 0.44 2.41e-14 Height; CESC trans rs11098499 0.697 rs28655325 chr4:120372999 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.86 0.52 9.55e-20 Corneal astigmatism; CESC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg02461776 chr11:598696 PHRF1 0.45 5.14 0.3 5.31e-7 Systemic lupus erythematosus; CESC cis rs2204008 0.837 rs34381557 chr12:38181983 T/C cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs1568889 0.838 rs11030185 chr11:28041904 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.82 13.94 0.65 1.69e-33 Bipolar disorder; CESC cis rs7429990 0.965 rs7427418 chr3:48022707 T/C cg11946769 chr3:48343235 NME6 -0.44 -5.37 -0.31 1.75e-7 Educational attainment (years of education); CESC cis rs7044106 0.762 rs1411158 chr9:123464804 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 12.92 0.62 5.92e-30 Hip circumference adjusted for BMI; CESC cis rs524281 0.731 rs11227439 chr11:66025679 G/A cg14036092 chr11:66035641 RAB1B -0.54 -5.28 -0.31 2.76e-7 Electroencephalogram traits; CESC cis rs72781680 1.000 rs72796358 chr2:24160132 T/A cg20701182 chr2:24300061 SF3B14 0.66 5.88 0.34 1.25e-8 Lymphocyte counts; CESC cis rs644799 1.000 rs1784135 chr11:95531748 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.09 -0.3 6.68e-7 Bipolar disorder; CESC cis rs7937682 0.889 rs1784787 chr11:111486125 T/A cg09085632 chr11:111637200 PPP2R1B -0.95 -14.6 -0.67 8.26e-36 Primary sclerosing cholangitis; CESC cis rs6701037 0.681 rs34370567 chr1:175131340 C/T cg00321850 chr1:175162397 KIAA0040 -0.43 -6.42 -0.37 6.11e-10 Alcohol dependence; CESC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg24503407 chr1:205819492 PM20D1 0.39 5.15 0.3 5.05e-7 Parkinson's disease; CESC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg22535103 chr8:58192502 C8orf71 0.95 10.17 0.53 1.01e-20 Developmental language disorder (linguistic errors); CESC cis rs10883723 0.810 rs7090034 chr10:104281155 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.59 0.42 5.46e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg05340658 chr4:99064831 C4orf37 0.76 11.06 0.56 1.24e-23 Colonoscopy-negative controls vs population controls; CESC cis rs8072100 0.713 rs11079776 chr17:45546893 C/T cg25173405 chr17:45401733 C17orf57 -0.45 -5.75 -0.33 2.39e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg23172400 chr8:95962367 TP53INP1 -0.46 -9.62 -0.51 5.59e-19 Type 2 diabetes; CESC trans rs61931739 0.500 rs6488218 chr12:34452587 T/C cg26384229 chr12:38710491 ALG10B 0.58 8.31 0.45 5.18e-15 Morning vs. evening chronotype; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg05108160 chr13:110790284 NA -0.45 -6.46 -0.37 5.06e-10 Height; CESC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg00166722 chr3:10149974 C3orf24 -0.51 -6.51 -0.37 3.79e-10 Alzheimer's disease; CESC cis rs1801251 1.000 rs2592105 chr2:233645968 C/G cg25237894 chr2:233734115 C2orf82 0.46 7.93 0.44 6.06e-14 Coronary artery disease; CESC cis rs2425143 1.000 rs6060524 chr20:34221155 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.1 0.3 6.33e-7 Blood protein levels; CESC trans rs2727020 0.729 rs1164685 chr11:49293660 G/A cg03929089 chr4:120376271 NA 0.78 11.9 0.59 1.85e-26 Coronary artery disease; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg04141094 chr2:54785178 SPTBN1 0.46 6.82 0.39 5.98e-11 Vertical cup-disc ratio; CESC cis rs9640161 0.789 rs6964110 chr7:150041836 A/C cg10018233 chr7:150070692 REPIN1 0.33 5.05 0.3 8.38e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg27511265 chr7:150102280 LOC728743 0.52 6.61 0.38 2.12e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs644799 1.000 rs516551 chr11:95588626 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.28 0.36 1.34e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6456156 0.774 rs1012657 chr6:167525142 A/C cg07741184 chr6:167504864 NA -0.31 -5.26 -0.31 3e-7 Primary biliary cholangitis; CESC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.64 8.85 0.48 1.28e-16 Alzheimer's disease; CESC cis rs2230307 0.536 rs684519 chr1:100604715 T/G cg24955406 chr1:100503596 HIAT1 -0.49 -5.18 -0.3 4.29e-7 Carotid intima media thickness; CESC trans rs587847 0.507 rs10518956 chr15:37808780 A/G cg22493172 chr12:51611826 POU6F1 -0.5 -6.02 -0.35 5.85e-9 Intraocular pressure; CESC cis rs9300255 0.664 rs12316131 chr12:123817796 T/C cg19016782 chr12:123741754 C12orf65 0.44 6.13 0.35 3.09e-9 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00252696 chr1:31769601 ZCCHC17;SNRNP40 0.57 6.97 0.39 2.47e-11 Gut microbiome composition (summer); CESC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.14 -0.3 5.31e-7 Life satisfaction; CESC trans rs748404 0.631 rs1133395 chr15:43650384 G/A cg24053811 chr14:70265306 SLC10A1 0.44 6.2 0.36 2.16e-9 Lung cancer; CESC cis rs2274273 1.000 rs11621351 chr14:55616740 C/A cg04306507 chr14:55594613 LGALS3 0.29 5.32 0.31 2.25e-7 Protein biomarker; CESC cis rs7267979 0.789 rs6083841 chr20:25384564 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.7 -11.59 -0.58 2.18e-25 Liver enzyme levels (alkaline phosphatase); CESC cis rs10870270 1.000 rs9971066 chr10:133788233 G/A cg08754478 chr10:133766260 PPP2R2D -0.58 -7.38 -0.41 2.03e-12 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2120019 1.000 rs7167285 chr15:75368769 A/G cg17294928 chr15:75287854 SCAMP5 -0.59 -6.62 -0.38 1.97e-10 Blood trace element (Zn levels); CESC cis rs7917772 0.532 rs10748829 chr10:104527244 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.45 -5.29 -0.31 2.59e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1387259 0.839 rs7487682 chr12:48579665 A/C cg04545296 chr12:48745243 ZNF641 -0.38 -6.69 -0.38 1.33e-10 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs8017423 0.872 rs7492857 chr14:90684867 T/G cg14092571 chr14:90743983 NA 0.53 7.97 0.44 4.65e-14 Mortality in heart failure; CESC cis rs13392177 0.637 rs61041183 chr2:219056380 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.57 7.51 0.42 9.04e-13 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs1878931 0.520 rs12447807 chr16:3413896 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 1.04 16.79 0.72 1.35e-43 Body mass index (adult); CESC cis rs9300255 0.568 rs1047158 chr12:123644056 C/A cg05973401 chr12:123451056 ABCB9 0.5 5.81 0.34 1.79e-8 Neutrophil percentage of white cells; CESC cis rs6424115 0.830 rs2501431 chr1:24201643 G/A cg10978503 chr1:24200527 CNR2 0.33 6.6 0.38 2.2e-10 Immature fraction of reticulocytes; CESC cis rs8067545 0.611 rs7219908 chr17:20043036 A/G cg13482628 chr17:19912719 NA 0.4 5.37 0.31 1.75e-7 Schizophrenia; CESC cis rs8114671 0.562 rs725521 chr20:33516071 T/C cg06115741 chr20:33292138 TP53INP2 0.48 5.79 0.34 1.97e-8 Height; CESC cis rs6582630 0.519 rs11609739 chr12:38547969 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.77 0.55 1.13e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs734999 0.611 rs10797431 chr1:2501222 G/T cg20673091 chr1:2541236 MMEL1 0.4 6.61 0.38 2.08e-10 Ulcerative colitis; CESC cis rs3747547 0.710 rs2091415 chr9:37951176 T/C cg13774184 chr9:37916125 SHB -0.55 -5.82 -0.34 1.71e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg12463550 chr7:65579703 CRCP -0.46 -5.81 -0.34 1.76e-8 Aortic root size; CESC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg03388025 chr16:89894329 SPIRE2 0.42 8.12 0.45 1.76e-14 Vitiligo; CESC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg20151795 chr6:28129481 ZNF389 0.35 5.06 0.3 7.95e-7 Cardiac Troponin-T levels; CESC cis rs67311347 0.577 rs1317217 chr3:40271697 T/G cg09455208 chr3:40491958 NA 0.36 5.58 0.32 5.81e-8 Renal cell carcinoma; CESC cis rs4253772 0.530 rs9615349 chr22:46732418 T/G cg00784671 chr22:46762841 CELSR1 -0.64 -6.13 -0.35 3.22e-9 LDL cholesterol;Cholesterol, total; CESC cis rs2901656 0.691 rs10798005 chr1:172382965 C/T cg03748243 chr1:172413542 C1orf105;PIGC -0.46 -7.21 -0.41 5.8e-12 Red cell distribution width;Platelet distribution width; CESC cis rs2070488 0.775 rs1132064 chr3:38566519 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.78 -12.87 -0.62 9.13e-30 Electrocardiographic conduction measures; CESC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg07936489 chr17:37558343 FBXL20 0.75 10.13 0.53 1.32e-20 Glomerular filtration rate (creatinine); CESC cis rs9902453 0.791 rs3098950 chr17:27998385 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.79 10.74 0.55 1.47e-22 Coffee consumption (cups per day); CESC cis rs11792861 0.781 rs28361106 chr9:111762385 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -5.5 -0.32 9.01e-8 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08797741 chr3:47555315 C3orf75 0.58 6.53 0.37 3.39e-10 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.4 0.57 9.22e-25 Alzheimer's disease; CESC cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg09555818 chr19:45449301 APOC2 -0.48 -7.3 -0.41 3.3e-12 Blood protein levels; CESC cis rs3091242 0.933 rs9438905 chr1:25764177 A/G cg27572855 chr1:25598939 RHD 0.44 7.35 0.41 2.45e-12 Erythrocyte sedimentation rate; CESC cis rs4319547 0.656 rs10773088 chr12:122828069 A/T cg05707623 chr12:122985044 ZCCHC8 -0.5 -5.73 -0.33 2.7e-8 Body mass index; CESC cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg19077165 chr18:44547161 KATNAL2 0.54 7.97 0.44 4.82e-14 Personality dimensions; CESC cis rs6433857 0.627 rs6741769 chr2:181500545 G/A cg23363182 chr2:181467187 NA -0.45 -6.8 -0.39 6.88e-11 Body mass index; CESC cis rs651907 0.535 rs11711903 chr3:101500748 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 5.69 0.33 3.31e-8 Colorectal cancer; CESC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg26314531 chr2:26401878 FAM59B -0.84 -8.92 -0.48 7.98e-17 Gut microbiome composition (summer); CESC cis rs10465746 0.809 rs2389617 chr1:84437652 A/T cg10977910 chr1:84465055 TTLL7 0.52 7.13 0.4 9.46e-12 Obesity-related traits; CESC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.49 0.37 4.3e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00407623 chr5:80597718 RNU5E;RNU5D;ZCCHC9 0.52 6.09 0.35 3.89e-9 Gut microbiome composition (summer); CESC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg18446336 chr7:2847575 GNA12 -0.39 -6.04 -0.35 5.12e-9 Height; CESC cis rs9309473 0.519 rs4852951 chr2:73869796 C/G cg20560298 chr2:73613845 ALMS1 0.51 7.11 0.4 1.08e-11 Metabolite levels; CESC cis rs3096299 0.606 rs2965946 chr16:89516612 T/C cg02187348 chr16:89574699 SPG7 0.5 6.07 0.35 4.31e-9 Multiple myeloma (IgH translocation); CESC cis rs8070624 0.543 rs7219320 chr17:17880877 A/G cg09796270 chr17:17721594 SREBF1 0.42 5.55 0.32 6.79e-8 Total body bone mineral density; CESC cis rs1371867 0.846 rs2919469 chr8:101233896 C/T cg11906718 chr8:101322791 RNF19A 0.5 6.34 0.36 9.95e-10 Atrioventricular conduction; CESC cis rs4566357 0.521 rs78411533 chr2:227910807 G/A cg05526886 chr2:227700861 RHBDD1 -0.45 -5.99 -0.35 6.98e-9 Coronary artery disease; CESC cis rs6754311 0.593 rs10186843 chr2:136586958 C/A cg15123519 chr2:136567270 LCT 0.34 5.7 0.33 3.11e-8 Mosquito bite size; CESC cis rs13064411 0.627 rs28710051 chr3:113143531 G/A cg18753928 chr3:113234510 CCDC52 -0.5 -5.62 -0.33 4.76e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs7542091 0.704 rs2142907 chr1:210039505 T/C cg21951975 chr1:209979733 IRF6 0.46 7.82 0.43 1.29e-13 Monobrow; CESC cis rs7429990 0.965 rs9854454 chr3:48012797 A/G cg11946769 chr3:48343235 NME6 -0.46 -5.69 -0.33 3.39e-8 Educational attainment (years of education); CESC cis rs9303401 0.659 rs17822908 chr17:56801778 T/C cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC cis rs2014572 0.870 rs10426580 chr19:57756221 G/A cg24459738 chr19:57751996 ZNF805 -0.54 -7.78 -0.43 1.67e-13 Hyperactive-impulsive symptoms; CESC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.53 0.37 3.43e-10 Prudent dietary pattern; CESC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.76e-18 Skin colour saturation; CESC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.84 0.43 1.14e-13 Prudent dietary pattern; CESC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg19717773 chr7:2847554 GNA12 -0.48 -7.01 -0.4 1.97e-11 Height; CESC cis rs6121246 0.559 rs6058462 chr20:30367674 C/T cg13852791 chr20:30311386 BCL2L1 0.81 10.44 0.54 1.31e-21 Mean corpuscular hemoglobin; CESC cis rs17764205 0.777 rs112570652 chr19:3255789 G/A cg02612712 chr19:3985498 EEF2 0.66 5.1 0.3 6.51e-7 Bipolar disorder and schizophrenia; CESC cis rs6570726 0.935 rs12663211 chr6:145818427 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs12477438 0.520 rs11123763 chr2:99750673 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.46 0.69 7.45e-39 Chronic sinus infection; CESC cis rs2708240 0.577 rs2373269 chr7:147567018 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 0.4 6.56 0.37 2.81e-10 QT interval (drug interaction); CESC cis rs9796 0.516 rs28473405 chr15:41293170 C/T cg18705301 chr15:41695430 NDUFAF1 -0.59 -8.22 -0.45 9.16e-15 Menopause (age at onset); CESC cis rs4481887 0.893 rs10888348 chr1:248448610 C/G cg00666640 chr1:248458726 OR2T12 0.36 6.24 0.36 1.7e-9 Common traits (Other); CESC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg26314531 chr2:26401878 FAM59B -0.77 -8.56 -0.47 9.38e-16 Gut microbiome composition (summer); CESC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -6.78 -0.38 7.61e-11 Bipolar disorder; CESC cis rs7737355 0.853 rs26005 chr5:130988029 A/G cg06307176 chr5:131281290 NA 0.47 5.61 0.33 5.22e-8 Life satisfaction; CESC cis rs12478296 0.681 rs55802421 chr2:243033962 C/T cg06360820 chr2:242988706 NA -0.7 -7.82 -0.43 1.29e-13 Obesity-related traits; CESC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg24578937 chr1:2090814 PRKCZ 0.38 6.62 0.38 2.03e-10 Height; CESC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg04234412 chr22:24373322 LOC391322 -0.6 -8.95 -0.48 6.51e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1348850 0.793 rs13000048 chr2:178337089 C/A cg23306229 chr2:178417860 TTC30B 0.64 8.23 0.45 8.59e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9457247 0.529 rs6907666 chr6:167523395 A/G cg07741184 chr6:167504864 NA -0.37 -6.76 -0.38 8.58e-11 Crohn's disease; CESC cis rs916888 0.821 rs199512 chr17:44857352 T/C cg15921436 chr17:44337874 NA -0.7 -7.95 -0.44 5.35e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg00255919 chr5:131827918 IRF1 0.35 5.29 0.31 2.62e-7 Breast cancer;Mosquito bite size; CESC cis rs4253772 0.938 rs41329344 chr22:46636930 C/T cg00784671 chr22:46762841 CELSR1 -0.57 -5.63 -0.33 4.54e-8 LDL cholesterol;Cholesterol, total; CESC trans rs11148252 0.574 rs7139495 chr13:53283318 A/G cg18335740 chr13:41363409 SLC25A15 0.52 7.11 0.4 1.1e-11 Lewy body disease; CESC trans rs6089829 0.925 rs13041507 chr20:61666180 T/C cg23505145 chr19:12996616 KLF1 0.52 6.8 0.39 6.85e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs7714584 1.000 rs11957134 chr5:150230950 A/G cg22134413 chr5:150180641 NA -0.56 -5.44 -0.32 1.18e-7 Crohn's disease; CESC cis rs13130787 0.567 rs280112 chr4:94919953 C/T cg11021082 chr4:95130006 SMARCAD1 -0.39 -5.49 -0.32 9.34e-8 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02809009 chr19:50354510 PTOV1 0.54 6.01 0.35 5.95e-9 Gut microbiome composition (summer); CESC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg06453172 chr10:134556979 INPP5A -0.39 -5.08 -0.3 7.01e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4234798 0.933 rs10020957 chr4:7222436 C/T cg18431297 chr4:7219810 SORCS2 -0.42 -7.21 -0.41 5.74e-12 Insulin-like growth factors; CESC cis rs7659604 1.000 rs72678650 chr4:122666000 A/G cg19671926 chr4:122722719 EXOSC9 -0.49 -5.92 -0.34 9.92e-9 Type 2 diabetes; CESC cis rs2559856 1.000 rs10860771 chr12:102087242 A/G cg12213457 chr12:102090980 CHPT1 -0.34 -5.1 -0.3 6.45e-7 Blood protein levels; CESC cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs3741489 1.000 rs10781661 chr12:133431979 G/A cg01499426 chr12:133417423 CHFR 0.95 6.29 0.36 1.29e-9 Cognitive function; CESC cis rs12930096 1.000 rs67188060 chr16:11679517 A/G cg07439791 chr16:11680400 LITAF 0.62 5.71 0.33 2.95e-8 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13318091 chr8:27145541 TRIM35 -0.6 -6.73 -0.38 1.04e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09356193 chr14:105816327 PACS2 -0.62 -6.97 -0.39 2.48e-11 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05332869 chr20:39658073 TOP1 0.55 7.11 0.4 1.09e-11 Gut microbiota (bacterial taxa); CESC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg19592336 chr6:28129416 ZNF389 0.47 6.86 0.39 4.78e-11 Cardiac Troponin-T levels; CESC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg26818010 chr10:134567672 INPP5A -0.94 -11.42 -0.57 7.62e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6563842 0.563 rs4575411 chr13:41277794 C/G cg21288729 chr13:41239152 FOXO1 0.57 7.59 0.42 5.49e-13 Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CESC cis rs2455799 0.552 rs2470516 chr3:15759050 T/G cg16303742 chr3:15540471 COLQ -0.4 -6.1 -0.35 3.83e-9 Mean platelet volume; CESC cis rs7833986 0.501 rs72653957 chr8:56990048 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.54 0.42 7.58e-13 Height; CESC cis rs17433780 0.897 rs12120863 chr1:89501522 T/C cg09516651 chr1:89888402 LOC400759 0.68 9.56 0.51 8.55e-19 Carotid intima media thickness; CESC cis rs72781680 1.000 rs72796326 chr2:24137047 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs4132509 0.779 rs10737888 chr1:243678483 A/C cg21452805 chr1:244014465 NA 0.42 5.15 0.3 5.03e-7 RR interval (heart rate); CESC cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg03467027 chr4:99064603 C4orf37 0.46 5.83 0.34 1.62e-8 Colonoscopy-negative controls vs population controls; CESC cis rs8017423 0.967 rs6575120 chr14:90725094 C/T cg14092571 chr14:90743983 NA -0.55 -8.27 -0.45 6.56e-15 Mortality in heart failure; CESC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg11764359 chr7:65958608 NA -0.94 -15.05 -0.68 1.96e-37 Aortic root size; CESC cis rs79387448 0.655 rs76930359 chr2:102924684 G/A cg09003973 chr2:102972529 NA 1.06 7.89 0.44 7.91e-14 Gut microbiota (bacterial taxa); CESC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg24531977 chr5:56204891 C5orf35 -0.7 -9.5 -0.5 1.35e-18 Initial pursuit acceleration; CESC cis rs1728785 0.901 rs698711 chr16:68561955 C/T cg02972257 chr16:68554789 NA -0.55 -6.45 -0.37 5.28e-10 Ulcerative colitis; CESC cis rs4737010 0.501 rs10099197 chr8:41654458 C/T cg08923054 chr8:41654455 ANK1 0.61 7.53 0.42 7.83e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs1018836 0.700 rs10504894 chr8:91516436 G/A cg16814680 chr8:91681699 NA -0.58 -7.66 -0.43 3.41e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs8114671 0.836 rs6060140 chr20:33566507 G/A cg24642439 chr20:33292090 TP53INP2 0.45 5.37 0.31 1.71e-7 Height; CESC cis rs9868809 0.881 rs13096357 chr3:48675856 C/A cg07636037 chr3:49044803 WDR6 -0.64 -5.22 -0.31 3.66e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs4728302 0.869 rs6962865 chr7:133599433 T/A cg10665199 chr7:133106180 EXOC4 0.42 5.83 0.34 1.57e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs9291683 0.588 rs13133766 chr4:10019732 C/T cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.51e-12 Bone mineral density; CESC cis rs13385 0.724 rs60714373 chr5:139651321 T/C cg26211634 chr5:139558579 C5orf32 0.47 5.05 0.3 8.24e-7 Atrial fibrillation; CESC cis rs2304069 0.545 rs6866616 chr5:149415401 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.48 6.66 0.38 1.58e-10 HIV-1 control; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg05577848 chr12:62798679 USP15 0.39 6.32 0.36 1.07e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs12464559 0.522 rs12472627 chr2:152633114 C/T cg01189475 chr2:152685088 ARL5A 0.79 7.64 0.42 4.04e-13 Response to cognitive-behavioural therapy in anxiety disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18703910 chr15:23157832 NA -0.48 -6.96 -0.39 2.63e-11 Gut microbiota (bacterial taxa); CESC cis rs9457247 1.000 rs364283 chr6:167383750 C/T cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.27e-8 Crohn's disease; CESC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg01988459 chr11:68622903 NA -0.42 -5.77 -0.33 2.25e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1568889 0.938 rs6484358 chr11:28260364 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.2 0.57 4.32e-24 Bipolar disorder; CESC cis rs909002 0.849 rs10798879 chr1:32096815 T/C cg13919466 chr1:32135498 COL16A1 -0.47 -8.03 -0.44 3.3e-14 Intelligence (multi-trait analysis); CESC cis rs9388451 0.868 rs10457467 chr6:126045148 T/A cg05901451 chr6:126070800 HEY2 -0.6 -8.66 -0.47 4.79e-16 Brugada syndrome; CESC cis rs12541635 0.966 rs1496182 chr8:107024505 C/T cg10147462 chr8:107024639 NA 0.42 6.05 0.35 4.79e-9 Age of smoking initiation; CESC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg21951975 chr1:209979733 IRF6 0.64 7.65 0.43 3.73e-13 Cleft lip with or without cleft palate; CESC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.99e-8 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04346515 chr15:62360465 C2CD4A 0.53 6.03 0.35 5.57e-9 Gut microbiome composition (summer); CESC cis rs1881797 0.932 rs4551631 chr1:247667663 C/T cg05639522 chr1:247681581 NA -0.55 -7.23 -0.41 5.18e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2075671 0.903 rs11983334 chr7:100302434 C/T cg20848291 chr7:100343083 ZAN -0.8 -10.11 -0.53 1.53e-20 Other erythrocyte phenotypes; CESC cis rs3126085 0.935 rs4845421 chr1:152173259 G/T cg03465714 chr1:152285911 FLG -0.45 -5.54 -0.32 7.45e-8 Atopic dermatitis; CESC cis rs7824557 0.564 rs7834572 chr8:11236685 C/T cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.52e-14 Retinal vascular caliber; CESC cis rs8067354 0.645 rs56236317 chr17:57822125 C/T cg13753209 chr17:57696993 CLTC 0.65 7.89 0.44 7.95e-14 Hemoglobin concentration; CESC cis rs6088580 0.634 rs945673 chr20:32964265 C/A cg08999081 chr20:33150536 PIGU -0.65 -11.29 -0.57 2.13e-24 Glomerular filtration rate (creatinine); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg08005411 chr12:69753742 YEATS4 0.5 6.42 0.37 6.13e-10 Thyroid stimulating hormone; CESC cis rs2439831 0.541 rs12440854 chr15:43610672 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.91 9.91 0.52 6.91e-20 Lung cancer in ever smokers; CESC cis rs1775715 0.769 rs2799030 chr10:32172935 G/T cg18675610 chr10:32216311 ARHGAP12 0.34 5.29 0.31 2.55e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs71403859 0.502 rs34015581 chr16:71508229 T/A cg08717414 chr16:71523259 ZNF19 -0.83 -8.0 -0.44 3.92e-14 Post bronchodilator FEV1; CESC cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg01383753 chr8:8559461 CLDN23 0.39 5.1 0.3 6.41e-7 Mood instability; CESC cis rs2735413 0.881 rs12918547 chr16:78082746 G/A cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7851660 0.809 rs10115216 chr9:100657119 G/T cg13688889 chr9:100608707 NA 0.62 8.83 0.48 1.42e-16 Strep throat; CESC cis rs9300255 0.602 rs2682434 chr12:123694724 C/T cg00376283 chr12:123451042 ABCB9 0.7 8.83 0.48 1.41e-16 Neutrophil percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17808901 chr3:39093368 WDR48 -0.46 -6.55 -0.37 2.93e-10 Gambling; CESC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg02099474 chr7:1027990 CYP2W1 -0.35 -5.19 -0.3 4.23e-7 Longevity;Endometriosis; CESC cis rs2204008 0.837 rs11183232 chr12:37941053 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.81 0.34 1.77e-8 Bladder cancer; CESC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg26335602 chr6:28129616 ZNF389 0.52 6.85 0.39 5.22e-11 Depression; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg13309628 chr20:3801056 C20orf29 0.6 6.08 0.35 4.07e-9 Diastolic blood pressure; CESC cis rs854765 0.583 rs950966 chr17:17783748 A/G cg04398451 chr17:18023971 MYO15A 0.63 8.87 0.48 1.09e-16 Total body bone mineral density; CESC cis rs17166499 0.803 rs73070141 chr7:12897219 A/G cg12945054 chr7:12841881 NA 0.49 5.22 0.31 3.58e-7 Bipolar disorder and schizophrenia; CESC cis rs992157 0.732 rs10932771 chr2:219170236 A/T cg20019365 chr2:219134978 PNKD;AAMP 0.65 8.94 0.48 6.73e-17 Colorectal cancer; CESC cis rs5758659 0.652 rs133322 chr22:42405659 A/G cg19513890 chr22:42538836 CYP2D7P1 -0.38 -5.38 -0.31 1.62e-7 Cognitive function; CESC cis rs1348850 0.914 rs2364854 chr2:178378452 T/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.74 10.31 0.54 3.56e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.53 0.32 7.67e-8 Bipolar disorder; CESC trans rs561341 0.629 rs7216107 chr17:30224419 G/A cg20587970 chr11:113659929 NA -0.54 -7.05 -0.4 1.53e-11 Hip circumference adjusted for BMI; CESC cis rs7666738 0.791 rs34152299 chr4:98929862 G/C cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs1059312 0.932 rs4760593 chr12:129287220 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.73 -10.11 -0.53 1.53e-20 Systemic lupus erythematosus; CESC cis rs941408 0.515 rs1736188 chr19:2782368 A/G cg06609049 chr19:2785107 THOP1 0.85 13.26 0.63 4.15e-31 Total cholesterol levels; CESC cis rs7546094 1.000 rs1994604 chr1:113156426 C/T cg22162597 chr1:113214053 CAPZA1 0.4 6.13 0.35 3.09e-9 Platelet distribution width; CESC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg17971929 chr21:40555470 PSMG1 -0.86 -12.31 -0.6 7.36e-28 Cognitive function; CESC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg18876405 chr7:65276391 NA 0.67 9.34 0.5 4.12e-18 Aortic root size; CESC cis rs2228479 0.850 rs11640209 chr16:89807828 C/A cg00800038 chr16:89945340 TCF25 -0.88 -7.38 -0.41 2.03e-12 Skin colour saturation; CESC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg07157834 chr1:205819609 PM20D1 0.72 10.57 0.54 5.18e-22 Menarche (age at onset); CESC cis rs9811920 0.609 rs793501 chr3:99591638 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs61996546 0.622 rs17560758 chr15:26836402 C/T cg15066197 chr15:26874202 GABRB3 -0.35 -5.07 -0.3 7.55e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg16339924 chr4:17578868 LAP3 0.76 9.55 0.51 9.19e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs55871839 0.643 rs10109566 chr8:59800446 A/G cg07426533 chr8:59803705 TOX -0.5 -7.16 -0.4 8.11e-12 Pneumonia; CESC cis rs7927592 0.913 rs7107622 chr11:68374183 T/C cg16797656 chr11:68205561 LRP5 0.37 5.27 0.31 2.81e-7 Total body bone mineral density; CESC cis rs6460942 0.545 rs17448114 chr7:12524458 G/C cg20607287 chr7:12443886 VWDE -0.71 -7.67 -0.43 3.19e-13 Coronary artery disease; CESC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg23758822 chr17:41437982 NA 1.04 16.2 0.71 1.74e-41 Menopause (age at onset); CESC cis rs9815354 0.812 rs73081383 chr3:41920614 A/G cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.93e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs212524 0.544 rs9426748 chr1:21558490 C/A cg05370193 chr1:21551575 ECE1 0.41 6.43 0.37 5.82e-10 Height; CESC cis rs2816062 0.813 rs2816051 chr1:18895460 A/G cg18795169 chr1:18902165 NA -0.94 -19.04 -0.76 1.61e-51 Urate levels in lean individuals; CESC cis rs9325144 0.600 rs10748442 chr12:38732939 A/T cg26384229 chr12:38710491 ALG10B 0.56 8.07 0.44 2.52e-14 Morning vs. evening chronotype; CESC cis rs10751667 0.857 rs6597952 chr11:991109 C/G cg06064525 chr11:970664 AP2A2 -0.42 -7.08 -0.4 1.27e-11 Alzheimer's disease (late onset); CESC cis rs7843479 0.965 rs11784535 chr8:21857787 G/A cg17168535 chr8:21777572 XPO7 0.48 6.58 0.37 2.51e-10 Mean corpuscular volume; CESC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 6.81 0.39 6.62e-11 Melanoma; CESC cis rs2708240 1.000 rs2538988 chr7:147580325 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.67 -0.33 3.73e-8 QT interval (drug interaction); CESC cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg13628971 chr7:2884303 GNA12 0.61 7.0 0.4 2.08e-11 Height; CESC cis rs55788414 0.932 rs2873367 chr16:81184380 T/A cg06400318 chr16:81190750 PKD1L2 -0.6 -6.82 -0.39 6.19e-11 Left ventricular obstructive tract defect (maternal effect); CESC trans rs61931739 0.890 rs694706 chr12:34135323 T/C cg26384229 chr12:38710491 ALG10B 0.44 6.08 0.35 4.25e-9 Morning vs. evening chronotype; CESC cis rs2933343 1.000 rs1683778 chr3:128644595 A/G cg25356066 chr3:128598488 ACAD9 0.61 7.52 0.42 8.33e-13 IgG glycosylation; CESC cis rs5758511 0.514 rs5751221 chr22:42516366 C/T cg00645731 chr22:42541494 CYP2D7P1 0.63 9.78 0.52 1.69e-19 Birth weight; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16714616 chr20:40247229 CHD6 -0.52 -7.24 -0.41 4.98e-12 Gut microbiota (bacterial taxa); CESC cis rs854765 0.575 rs7207821 chr17:17891781 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.24 0.36 1.72e-9 Total body bone mineral density; CESC cis rs6912958 0.754 rs7762864 chr6:88236213 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -5.27 -0.31 2.82e-7 Monocyte percentage of white cells; CESC cis rs78456975 1.000 rs10189336 chr2:1558015 G/A cg26248373 chr2:1572462 NA -0.6 -5.65 -0.33 4.03e-8 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs854765 0.647 rs721669 chr17:18005073 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.63 8.94 0.48 6.96e-17 Total body bone mineral density; CESC cis rs12530845 0.943 rs78188670 chr7:135335163 T/C cg23117316 chr7:135346802 PL-5283 -0.41 -5.24 -0.31 3.35e-7 Red blood cell traits; CESC trans rs459571 0.883 rs2520096 chr9:136919416 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.57 -7.58 -0.42 5.76e-13 Platelet distribution width; CESC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg22823121 chr1:150693482 HORMAD1 0.47 7.04 0.4 1.62e-11 Tonsillectomy; CESC trans rs35110281 0.714 rs2282526 chr21:45080552 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 6.65 0.38 1.71e-10 Mean corpuscular volume; CESC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg23161317 chr6:28129485 ZNF389 0.38 5.3 0.31 2.4e-7 Parkinson's disease; CESC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg25072359 chr17:41440525 NA 0.45 5.96 0.34 7.83e-9 Menopause (age at onset); CESC cis rs1670533 0.697 rs658846 chr4:1084723 G/C cg04106633 chr4:1044584 NA 0.46 5.15 0.3 5.03e-7 Recombination rate (females); CESC cis rs6674176 0.597 rs4660262 chr1:44382524 G/A cg23954153 chr1:44402353 ARTN -0.36 -5.83 -0.34 1.57e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4975616 0.686 rs37011 chr5:1348798 A/T cg07493874 chr5:1342172 CLPTM1L -0.43 -8.27 -0.45 6.75e-15 Lung cancer; CESC cis rs7264396 0.747 rs6058291 chr20:34247769 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.77 0.43 1.78e-13 Total cholesterol levels; CESC cis rs4835473 0.932 rs13117421 chr4:144690558 A/G cg25736465 chr4:144833511 NA -0.42 -6.33 -0.36 1.05e-9 Immature fraction of reticulocytes; CESC cis rs6088580 0.634 rs945673 chr20:32964265 C/A cg24642439 chr20:33292090 TP53INP2 -0.54 -7.09 -0.4 1.2e-11 Glomerular filtration rate (creatinine); CESC cis rs1018836 0.923 rs1858674 chr8:91580665 G/T cg16814680 chr8:91681699 NA -0.69 -9.71 -0.51 2.82e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.99 0.35 6.84e-9 Tonsillectomy; CESC cis rs2836633 0.931 rs2836635 chr21:40069850 A/G cg05519781 chr21:40033154 ERG 0.52 7.91 0.44 6.9e-14 Coronary artery disease; CESC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg03396347 chr1:1875803 NA -0.46 -7.21 -0.41 5.71e-12 Body mass index; CESC cis rs9815354 0.812 rs113144620 chr3:42008312 A/G cg03022575 chr3:42003672 ULK4 0.68 6.35 0.36 9.13e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs2180341 0.597 rs3798859 chr6:127663116 C/T cg24812749 chr6:127587940 RNF146 0.6 8.01 0.44 3.64e-14 Breast cancer; CESC cis rs2712184 0.729 rs2541390 chr2:217664020 A/G cg05032264 chr2:217675019 NA -0.33 -5.06 -0.3 7.74e-7 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC cis rs60154123 0.730 rs583148 chr1:210463553 A/C cg21951975 chr1:209979733 IRF6 0.47 6.29 0.36 1.29e-9 Coronary artery disease; CESC cis rs644799 0.965 rs3789960 chr11:95509037 C/G cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.76 0.38 8.9e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.65 8.7 0.47 3.55e-16 Total body bone mineral density; CESC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg17178900 chr1:205818956 PM20D1 0.8 13.19 0.63 7.15e-31 Menarche (age at onset); CESC cis rs9929218 0.731 rs72785179 chr16:68767912 C/T cg02972257 chr16:68554789 NA 0.54 6.29 0.36 1.28e-9 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03386556 chr1:113499109 SLC16A1 -0.52 -6.17 -0.35 2.6e-9 Gut microbiome composition (summer); CESC cis rs9359856 0.564 rs7682 chr6:90352862 G/A cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.23 -0.36 1.83e-9 Bipolar disorder; CESC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg21017887 chr14:105400489 NA 0.41 6.65 0.38 1.65e-10 Rheumatoid arthritis; CESC cis rs1865721 0.771 rs727893 chr18:73136931 G/A cg26385618 chr18:73139727 C18orf62 -0.49 -7.96 -0.44 5.22e-14 Intelligence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13596910 chr17:42254336 C17orf65;ASB16 -0.54 -6.05 -0.35 5e-9 Gut microbiome composition (summer); CESC cis rs7267979 0.966 rs2263204 chr20:25377688 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -16.61 -0.71 6.07e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs72634258 0.554 rs35307738 chr1:7919839 C/G cg00042356 chr1:8021962 PARK7 0.59 5.65 0.33 4.15e-8 Inflammatory bowel disease; CESC cis rs12220238 0.818 rs10430521 chr10:75913590 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.23 0.36 1.87e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg16680214 chr1:154839983 KCNN3 -0.43 -6.6 -0.38 2.2e-10 Prostate cancer; CESC cis rs6011002 0.810 rs76832249 chr20:62307776 A/G cg15212369 chr20:62274085 STMN3 -0.59 -5.11 -0.3 6.25e-7 Dental caries; CESC cis rs4727027 0.933 rs1044358 chr7:148879951 C/A cg23583168 chr7:148888333 NA -0.83 -12.67 -0.61 4.51e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4237845 0.761 rs11172378 chr12:58298161 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.48 5.34 0.31 1.98e-7 Intelligence (multi-trait analysis); CESC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg24829409 chr8:58192753 C8orf71 -0.75 -9.78 -0.51 1.74e-19 Developmental language disorder (linguistic errors); CESC cis rs11779988 0.511 rs6586684 chr8:17925331 A/G cg18067069 chr8:17937731 ASAH1 0.4 5.52 0.32 8.12e-8 Breast cancer; CESC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg19622623 chr12:86230825 RASSF9 -0.45 -5.73 -0.33 2.68e-8 Major depressive disorder; CESC cis rs864537 0.618 rs2995089 chr1:167431193 G/A cg09179987 chr1:167433047 CD247 0.54 8.01 0.44 3.61e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07156929 chr6:34856927 ANKS1A;TAF11 -0.45 -6.4 -0.37 6.92e-10 Fibrinogen levels; CESC cis rs6495122 0.699 rs34862454 chr15:75101530 C/T cg14664628 chr15:75095509 CSK -0.71 -9.75 -0.51 2.13e-19 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg25036284 chr2:26402008 FAM59B 0.55 6.55 0.37 2.94e-10 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC cis rs7914558 0.933 rs12763665 chr10:104653717 G/A cg08650961 chr10:104748594 CNNM2 0.33 5.37 0.31 1.75e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12995491 1.000 rs12995491 chr2:88527414 C/T cg14558114 chr2:88469736 THNSL2 0.47 6.76 0.38 8.88e-11 Response to metformin (IC50); CESC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg04166393 chr7:2884313 GNA12 0.58 7.3 0.41 3.4e-12 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18705916 chr5:1800069 MRPL36;NDUFS6 0.6 7.08 0.4 1.33e-11 Gut microbiome composition (summer); CESC trans rs1814175 0.645 rs4598671 chr11:50003191 C/A cg03929089 chr4:120376271 NA -0.91 -14.65 -0.67 5.08e-36 Height; CESC cis rs13102973 0.965 rs9998499 chr4:135869362 G/A cg14419869 chr4:135874104 NA -0.4 -6.41 -0.37 6.73e-10 Subjective well-being; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg06722285 chr1:61925875 NFIA 0.4 6.14 0.35 3.02e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg26314531 chr2:26401878 FAM59B -0.62 -6.99 -0.39 2.29e-11 Gut microbiome composition (summer); CESC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg09177884 chr7:1199841 ZFAND2A -0.54 -6.08 -0.35 4.25e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs76419734 0.558 rs10030620 chr4:106574536 A/G cg24545054 chr4:106630052 GSTCD;INTS12 0.76 9.39 0.5 2.89e-18 Post bronchodilator FEV1; CESC cis rs5995756 0.761 rs6001638 chr22:40003267 T/C cg03390717 chr22:39966585 CACNA1I -0.35 -6.15 -0.35 2.79e-9 Autism spectrum disorder or schizophrenia; CESC cis rs763121 0.815 rs12168758 chr22:38997269 C/G cg06544989 chr22:39130855 UNC84B 0.47 8.58 0.47 8.06e-16 Menopause (age at onset); CESC cis rs10214930 0.671 rs3944121 chr7:27880888 A/C cg05786569 chr7:27702416 HIBADH 0.43 5.07 0.3 7.64e-7 Hypospadias; CESC cis rs7100689 0.754 rs1934695 chr10:82125230 T/C cg00277334 chr10:82204260 NA -0.59 -7.35 -0.41 2.39e-12 Post bronchodilator FEV1; CESC cis rs7666738 0.546 rs3911415 chr4:98692401 T/A cg17366294 chr4:99064904 C4orf37 0.49 6.04 0.35 5.12e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7165102 1.000 rs4351999 chr15:65992380 T/C cg11441148 chr15:65824328 PTPLAD1 0.31 5.07 0.3 7.51e-7 Mean corpuscular hemoglobin; CESC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg18230493 chr5:56204884 C5orf35 0.8 9.47 0.5 1.63e-18 Initial pursuit acceleration; CESC cis rs3806843 0.868 rs2563291 chr5:140119599 T/A cg26395211 chr5:140044315 WDR55 0.4 5.08 0.3 7.2e-7 Depressive symptoms (multi-trait analysis); CESC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg06420487 chr17:61919686 SMARCD2 0.45 5.36 0.31 1.82e-7 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27551657 chr1:109618774 TAF13 -0.44 -6.07 -0.35 4.4e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs35306767 0.903 rs765867 chr10:869901 G/T cg26597838 chr10:835615 NA 0.9 9.51 0.5 1.2e-18 Eosinophil percentage of granulocytes; CESC cis rs9788682 0.895 rs3813570 chr15:78832832 T/C cg06917634 chr15:78832804 PSMA4 -0.57 -6.61 -0.38 2.15e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg27170947 chr2:26402098 FAM59B -0.72 -8.31 -0.45 5.18e-15 Gut microbiome composition (summer); CESC cis rs10089 1.000 rs7713877 chr5:127428825 G/T cg19767477 chr5:127420684 SLC12A2 -0.41 -5.55 -0.32 6.89e-8 Ileal carcinoids; CESC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg23978390 chr7:1156363 C7orf50 0.41 5.58 0.32 6.04e-8 Longevity;Endometriosis; CESC cis rs9488822 0.676 rs7774952 chr6:116380909 A/G cg26893134 chr6:116381904 FRK 0.25 6.19 0.36 2.27e-9 Cholesterol, total;LDL cholesterol; CESC cis rs8114671 0.742 rs6058161 chr20:33620026 C/T cg24642439 chr20:33292090 TP53INP2 -0.45 -5.44 -0.32 1.19e-7 Height; CESC cis rs8180040 0.845 rs295441 chr3:47333295 T/A cg27129171 chr3:47204927 SETD2 0.66 10.09 0.53 1.82e-20 Colorectal cancer; CESC cis rs722599 0.748 rs17093914 chr14:75363641 A/G cg08847533 chr14:75593920 NEK9 0.47 5.62 0.33 4.88e-8 IgG glycosylation; CESC cis rs11650494 1.000 rs11650494 chr17:47345186 G/A cg08112188 chr17:47440006 ZNF652 0.68 5.05 0.3 8.21e-7 Prostate cancer; CESC cis rs4843747 0.671 rs9933794 chr16:88116981 T/C cg03395651 chr16:88107091 BANP 0.48 5.56 0.32 6.74e-8 Menopause (age at onset); CESC cis rs17023223 0.537 rs12081198 chr1:119686104 A/C cg05756136 chr1:119680316 WARS2 -0.46 -5.57 -0.32 6.27e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs4919087 0.683 rs11189121 chr10:99072036 T/C cg25902810 chr10:99078978 FRAT1 -0.5 -5.67 -0.33 3.79e-8 Monocyte count; CESC cis rs6460942 0.659 rs13247187 chr7:12551851 T/C cg02935154 chr7:12443704 VWDE -0.56 -5.66 -0.33 3.93e-8 Coronary artery disease; CESC cis rs4073582 0.595 rs528842 chr11:66032390 G/A cg14036092 chr11:66035641 RAB1B 0.57 7.86 0.43 9.65e-14 Gout; CESC cis rs782590 0.522 rs12329050 chr2:55894428 G/A cg18811423 chr2:55921094 PNPT1 -0.7 -10.68 -0.55 2.17e-22 Metabolic syndrome; CESC cis rs79349575 0.783 rs12602746 chr17:47031741 A/C cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg04772025 chr11:68637568 NA 0.5 5.95 0.34 8.36e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4588572 0.686 rs116246588 chr5:77683144 T/G cg11547950 chr5:77652471 NA 0.46 5.94 0.34 8.76e-9 Triglycerides; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05529236 chr11:62341449 EEF1G -0.47 -6.24 -0.36 1.75e-9 Fibrinogen levels; CESC cis rs7200543 0.848 rs62039480 chr16:15137450 G/A cg07549590 chr16:15018862 NA -0.35 -5.04 -0.3 8.81e-7 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; CESC cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg09060608 chr5:178986726 RUFY1 0.46 6.44 0.37 5.53e-10 Lung cancer; CESC cis rs7103648 0.630 rs7934481 chr11:47883337 C/T cg20307385 chr11:47447363 PSMC3 0.79 11.82 0.59 3.55e-26 Diastolic blood pressure;Systolic blood pressure; CESC cis rs6061231 1.000 rs13043313 chr20:60958269 A/G cg06197360 chr20:60970103 CABLES2 -0.4 -5.19 -0.3 4.24e-7 Colorectal cancer; CESC cis rs2243480 1.000 rs781149 chr7:65481284 C/T cg13147721 chr7:65941812 NA -0.86 -8.36 -0.46 3.7e-15 Diabetic kidney disease; CESC cis rs3768617 0.510 rs4651145 chr1:183098900 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs7635838 0.892 rs9814907 chr3:11438645 G/A cg00170343 chr3:11313890 ATG7 0.42 5.54 0.32 7.14e-8 HDL cholesterol; CESC cis rs4535700 0.501 rs28828764 chr7:55988679 T/C cg09872392 chr7:56161020 PHKG1 0.41 5.81 0.34 1.8e-8 Macular telangiectasia type 2; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg03760483 chr17:6899297 ALOX12 0.44 7.93 0.44 6.01e-14 Tonsillectomy; CESC cis rs4666360 1.000 rs4233757 chr2:20336077 G/A cg23291376 chr2:20336282 NA -0.36 -5.99 -0.35 6.84e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel); CESC trans rs1436955 0.712 rs7164482 chr15:62382883 A/C cg24704476 chr1:956799 AGRN 0.32 6.15 0.35 2.87e-9 Type 2 diabetes; CESC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.61 0.42 4.95e-13 Prudent dietary pattern; CESC cis rs2979489 0.841 rs2015311 chr8:30306989 A/G cg26383811 chr8:30366931 RBPMS 0.84 9.92 0.52 6.18e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.54 -7.25 -0.41 4.55e-12 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21759057 chr19:983033 WDR18 0.66 7.52 0.42 8.54e-13 Gut microbiome composition (summer); CESC cis rs11608355 0.515 rs12831026 chr12:109903651 C/T cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg11987759 chr7:65425863 GUSB -0.48 -6.56 -0.37 2.82e-10 Calcium levels; CESC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg11301795 chr4:187892539 NA 0.8 14.15 0.66 2.94e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs7937682 0.921 rs1944119 chr11:111436387 A/G cg09085632 chr11:111637200 PPP2R1B 0.95 12.0 0.59 9e-27 Primary sclerosing cholangitis; CESC cis rs7310409 0.544 rs1169292 chr12:121426478 C/T cg02403541 chr12:121454288 C12orf43 0.66 8.65 0.47 4.89e-16 Liver enzyme levels (gamma-glutamyl transferase);C-reactive protein;Pancreatic cancer; CESC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg07870213 chr5:140052090 DND1 -0.62 -6.92 -0.39 3.37e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs7980799 0.649 rs12819439 chr12:33684509 A/C cg26384229 chr12:38710491 ALG10B 0.58 8.14 0.45 1.59e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg16145915 chr7:1198662 ZFAND2A -0.44 -6.25 -0.36 1.6e-9 Longevity;Endometriosis; CESC trans rs116095464 0.558 rs7708515 chr5:234989 C/G cg00938859 chr5:1591904 SDHAP3 0.62 6.76 0.38 8.74e-11 Breast cancer; CESC cis rs3762637 0.943 rs3817040 chr3:122254769 G/A cg24169773 chr3:122142474 KPNA1 -0.59 -6.85 -0.39 5.17e-11 LDL cholesterol levels; CESC cis rs17376456 0.877 rs35747258 chr5:93310129 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.33 0.31 2.15e-7 Diabetic retinopathy; CESC cis rs2070433 1.000 rs2839302 chr21:47952364 G/A cg12379764 chr21:47803548 PCNT 0.62 7.2 0.4 6.16e-12 Lymphocyte counts; CESC cis rs35849525 1.000 rs35849525 chr3:50067350 T/C cg24110177 chr3:50126178 RBM5 -0.46 -5.41 -0.32 1.38e-7 Intelligence (multi-trait analysis); CESC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg16145915 chr7:1198662 ZFAND2A -0.53 -8.12 -0.45 1.81e-14 Longevity;Endometriosis; CESC cis rs8114671 0.836 rs6142294 chr20:33671497 A/G cg06115741 chr20:33292138 TP53INP2 -0.46 -5.52 -0.32 7.98e-8 Height; CESC cis rs8044868 0.530 rs2550868 chr16:72066072 G/A cg01557791 chr16:72042693 DHODH -0.47 -6.44 -0.37 5.52e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -6.24 -0.36 1.77e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg25517755 chr10:38738941 LOC399744 -0.46 -5.98 -0.34 7.23e-9 Extrinsic epigenetic age acceleration; CESC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg03709012 chr19:19516395 GATAD2A 1.01 15.71 0.69 9.73e-40 Tonsillectomy; CESC cis rs360798 0.512 rs7562149 chr2:63008414 A/G cg17519650 chr2:63277830 OTX1 -0.53 -7.12 -0.4 1.01e-11 Coronary artery disease; CESC trans rs61931739 0.500 rs11053189 chr12:34433455 G/A cg26384229 chr12:38710491 ALG10B 0.69 10.37 0.54 2.3e-21 Morning vs. evening chronotype; CESC cis rs854765 0.547 rs28537385 chr17:17902135 G/A cg09796270 chr17:17721594 SREBF1 0.37 5.14 0.3 5.47e-7 Total body bone mineral density; CESC trans rs629535 0.862 rs662725 chr8:70029616 C/T cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs7586673 0.930 rs6432667 chr2:161905001 T/C cg08807892 chr2:162101083 NA 0.49 6.33 0.36 1.03e-9 Intelligence (multi-trait analysis); CESC cis rs2050392 0.760 rs10826797 chr10:30690376 A/C cg25182066 chr10:30743637 MAP3K8 -0.4 -5.17 -0.3 4.66e-7 Inflammatory bowel disease; CESC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.62 0.47 6.21e-16 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17762331 chr12:7033470 ATN1 0.44 6.24 0.36 1.76e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1395 0.778 rs34618115 chr2:27418289 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 5.85 0.34 1.44e-8 Blood metabolite levels; CESC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg07157834 chr1:205819609 PM20D1 0.7 10.35 0.54 2.55e-21 Menarche (age at onset); CESC cis rs10870270 0.956 rs67378218 chr10:133752420 A/C cg08754478 chr10:133766260 PPP2R2D -0.6 -7.81 -0.43 1.37e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7828089 0.935 rs896375 chr8:22262098 A/G cg12081754 chr8:22256438 SLC39A14 0.42 5.69 0.33 3.4e-8 Verbal declarative memory; CESC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg00129232 chr17:37814104 STARD3 -0.54 -7.14 -0.4 9.08e-12 Glomerular filtration rate (creatinine); CESC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs11864453 1.000 rs2278027 chr16:72051369 A/G cg01557791 chr16:72042693 DHODH -0.68 -9.08 -0.49 2.58e-17 Fibrinogen levels; CESC cis rs754466 0.561 rs11002344 chr10:79709725 A/T cg17075019 chr10:79541650 NA -0.68 -6.79 -0.38 7.55e-11 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26877198 chr19:9938416 UBL5 -0.45 -6.35 -0.36 9.26e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg00149659 chr3:10157352 C3orf10 0.72 8.92 0.48 7.79e-17 Alzheimer's disease; CESC cis rs6582630 0.519 rs12372510 chr12:38293074 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.99 0.52 3.89e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs1448094 0.817 rs10863108 chr12:86328249 C/T cg02569458 chr12:86230093 RASSF9 0.45 6.43 0.37 5.79e-10 Major depressive disorder; CESC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.43 0.42 1.46e-12 Electroencephalogram traits; CESC trans rs35110281 0.774 rs2838321 chr21:44995488 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.55 0.37 3.02e-10 Mean corpuscular volume; CESC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -7.24 -0.41 4.88e-12 Bipolar disorder and schizophrenia; CESC cis rs644799 1.000 rs488246 chr11:95560473 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.76 0.38 8.51e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11098499 0.954 rs12499324 chr4:120393786 C/T cg09307838 chr4:120376055 NA 0.92 13.14 0.63 1.06e-30 Corneal astigmatism; CESC cis rs9818941 0.824 rs9838352 chr3:157760461 C/A cg08654915 chr3:157813417 NA -0.46 -7.48 -0.42 1.08e-12 Height; CESC trans rs61931739 0.534 rs10844774 chr12:34166764 C/T cg26384229 chr12:38710491 ALG10B 0.64 9.03 0.49 3.54e-17 Morning vs. evening chronotype; CESC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg18099408 chr3:52552593 STAB1 -0.31 -5.07 -0.3 7.43e-7 Bipolar disorder; CESC cis rs300703 0.872 rs7568288 chr2:276908 C/G cg21211680 chr2:198530 NA 0.86 7.44 0.42 1.39e-12 Blood protein levels; CESC cis rs7814319 0.838 rs10955067 chr8:97230982 C/T cg20787634 chr8:97240163 UQCRB -0.54 -6.6 -0.38 2.18e-10 Lung function (FVC); CESC cis rs10434923 1.000 rs1524430 chr7:156256318 G/A cg10571168 chr7:156583547 LMBR1 0.57 5.05 0.3 8.2e-7 Childhood ear infection; CESC cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg18305652 chr10:134549665 INPP5A 0.51 7.67 0.43 3.3e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6912958 1.000 rs2223880 chr6:88167897 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.35 -5.77 -0.33 2.24e-8 Monocyte percentage of white cells; CESC cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg10523679 chr1:76189770 ACADM 0.72 8.33 0.46 4.31e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7605827 0.930 rs1528622 chr2:15557535 A/T cg19274914 chr2:15703543 NA 0.31 5.54 0.32 7.4e-8 Educational attainment (years of education); CESC cis rs9318086 0.648 rs4067969 chr13:24469120 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.49 6.79 0.38 7.53e-11 Myopia (pathological); CESC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg01097406 chr16:89675127 NA 0.36 5.05 0.3 8.11e-7 Vitiligo; CESC cis rs6580649 0.941 rs7959755 chr12:48446318 T/A cg24011408 chr12:48396354 COL2A1 -0.42 -5.28 -0.31 2.67e-7 Lung cancer; CESC cis rs17539620 0.506 rs62432749 chr6:154839219 G/A cg17771515 chr6:154831774 CNKSR3 0.58 5.76 0.33 2.36e-8 Lipoprotein (a) levels; CESC cis rs7809950 1.000 rs2237677 chr7:107202502 A/C cg23024343 chr7:107201750 COG5 -0.37 -5.21 -0.3 3.89e-7 Coronary artery disease; CESC cis rs3780486 0.505 rs10813958 chr9:33165985 A/G cg13443165 chr9:33130375 B4GALT1 0.48 7.23 0.41 5.13e-12 IgG glycosylation; CESC cis rs9467711 0.659 rs35433030 chr6:26529890 G/A cg21479132 chr6:26055353 NA 0.72 5.15 0.3 5.19e-7 Autism spectrum disorder or schizophrenia; CESC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg24675658 chr1:53192096 ZYG11B -0.69 -9.82 -0.52 1.29e-19 Monocyte count; CESC trans rs4689592 0.503 rs66885632 chr4:7053738 T/C cg07817883 chr1:32538562 TMEM39B 0.69 6.67 0.38 1.46e-10 Monocyte percentage of white cells; CESC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg11890956 chr21:40555474 PSMG1 1.21 24.59 0.83 2.36e-70 Cognitive function; CESC cis rs3106136 0.872 rs13130583 chr4:95245543 T/C cg11021082 chr4:95130006 SMARCAD1 0.41 5.78 0.33 2.04e-8 Capecitabine sensitivity; CESC cis rs870825 0.616 rs7668009 chr4:185641998 A/C cg04058563 chr4:185651563 MLF1IP 0.66 7.1 0.4 1.18e-11 Blood protein levels; CESC cis rs7845219 0.544 rs4735332 chr8:95923660 C/T cg16049864 chr8:95962084 TP53INP1 -0.5 -7.43 -0.42 1.48e-12 Type 2 diabetes; CESC cis rs11190604 1.000 rs2295774 chr10:102265847 A/C cg07080220 chr10:102295463 HIF1AN 0.62 5.63 0.33 4.62e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg08736216 chr1:53307985 ZYG11A -0.4 -6.61 -0.38 2.09e-10 Monocyte count; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg22931738 chr3:128206823 GATA2 0.47 6.03 0.35 5.38e-9 Breast cancer;Type 2 diabetes; CESC cis rs7818688 0.697 rs11776186 chr8:95971968 A/G cg16049864 chr8:95962084 TP53INP1 0.57 5.64 0.33 4.29e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs7000551 0.646 rs2979302 chr8:22359156 G/A cg24804145 chr7:158144409 PTPRN2 -0.32 -6.1 -0.35 3.66e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs11792861 0.816 rs11791845 chr9:111683898 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.53 6.85 0.39 5.17e-11 Menarche (age at onset); CESC cis rs2898857 0.545 rs12942379 chr17:47358733 C/T cg08112188 chr17:47440006 ZNF652 0.46 5.79 0.34 1.97e-8 Cancer; CESC cis rs9660992 0.573 rs4400674 chr1:205218425 A/C cg21643547 chr1:205240462 TMCC2 0.39 5.36 0.31 1.81e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs6987853 0.787 rs2974358 chr8:42434403 T/C cg09913449 chr8:42400586 C8orf40 0.44 7.44 0.42 1.43e-12 Mean corpuscular hemoglobin concentration; CESC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg11764359 chr7:65958608 NA -0.95 -14.12 -0.66 3.94e-34 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05886006 chr1:161359784 NA -0.41 -6.05 -0.35 4.95e-9 Gambling; CESC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg27266027 chr21:40555129 PSMG1 0.45 5.19 0.3 4.14e-7 Cognitive function; CESC cis rs12477438 0.798 rs6740035 chr2:99576578 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.51 -0.54 7.92e-22 Chronic sinus infection; CESC cis rs6541297 0.703 rs678050 chr1:230313911 T/C cg20703242 chr1:230279135 GALNT2 -0.43 -5.6 -0.33 5.46e-8 Coronary artery disease; CESC cis rs362272 0.545 rs3129308 chr4:3309272 C/T cg14583973 chr4:3374767 RGS12 0.32 5.43 0.32 1.26e-7 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02166888 chr8:144409668 TOP1MT -0.58 -6.53 -0.37 3.37e-10 Gut microbiome composition (summer); CESC cis rs7851660 0.809 rs10984230 chr9:100660284 C/T cg13688889 chr9:100608707 NA -0.63 -8.74 -0.47 2.77e-16 Strep throat; CESC cis rs2882667 1.000 rs10515505 chr5:138313146 A/G cg04439458 chr5:138467593 SIL1 -0.33 -5.44 -0.32 1.24e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7727544 0.716 rs3844312 chr5:131582356 C/T cg14196790 chr5:131705035 SLC22A5 0.36 5.32 0.31 2.22e-7 Blood metabolite levels; CESC trans rs2488856 0.528 rs2455977 chr14:43562207 C/A cg14326805 chr9:71737756 TJP2 0.38 6.15 0.35 2.9e-9 Osteoprotegerin levels; CESC cis rs4474465 0.850 rs4944205 chr11:78227790 T/A cg27205649 chr11:78285834 NARS2 0.45 5.58 0.32 6.09e-8 Alzheimer's disease (survival time); CESC cis rs911555 0.755 rs2756135 chr14:103962579 G/A cg24130564 chr14:104152367 KLC1 0.48 6.21 0.36 2.09e-9 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10522326 chr1:16134171 UQCRHL 0.4 6.07 0.35 4.52e-9 Gambling; CESC cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg12412775 chr1:25698385 RHCE -0.3 -5.42 -0.32 1.32e-7 Erythrocyte sedimentation rate; CESC cis rs826838 0.935 rs1684406 chr12:39127265 A/G cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.53e-9 Heart rate; CESC cis rs9900062 0.586 rs6504250 chr17:62680553 T/C cg02598441 chr17:62777298 LOC146880 -0.49 -5.14 -0.3 5.45e-7 QT interval; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06057208 chr16:30535933 ZNF768 -0.44 -6.3 -0.36 1.25e-9 Gut microbiota (bacterial taxa); CESC cis rs11696501 0.539 rs6073849 chr20:44299385 A/T cg11783356 chr20:44313418 WFDC10B -0.32 -5.12 -0.3 5.77e-7 Brain structure; CESC cis rs6665290 0.904 rs7541033 chr1:227188371 C/A cg10327440 chr1:227177885 CDC42BPA -1.2 -31.28 -0.89 6.16e-91 Myeloid white cell count; CESC cis rs4727963 0.819 rs59939536 chr7:122727787 A/T cg03640110 chr7:122635026 TAS2R16 -0.37 -5.68 -0.33 3.56e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs4253772 0.591 rs6007747 chr22:46657261 A/G cg24881330 chr22:46731750 TRMU 0.88 9.77 0.51 1.81e-19 LDL cholesterol;Cholesterol, total; CESC cis rs9291683 0.609 rs13149985 chr4:10028390 G/A cg11266682 chr4:10021025 SLC2A9 0.7 13.98 0.65 1.25e-33 Bone mineral density; CESC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg02807482 chr3:125708958 NA -0.39 -5.07 -0.3 7.59e-7 Blood pressure (smoking interaction); CESC cis rs17253792 0.822 rs79022053 chr14:56071721 A/G cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17499729 chr21:37504755 NA -0.64 -7.5 -0.42 9.41e-13 Gut microbiome composition (summer); CESC cis rs8141529 0.732 rs5997408 chr22:29207915 G/A cg15103426 chr22:29168792 CCDC117 0.68 9.72 0.51 2.71e-19 Lymphocyte counts; CESC cis rs9303280 0.806 rs8069176 chr17:38057197 G/A cg19468946 chr17:37922297 IKZF3 -0.39 -5.18 -0.3 4.33e-7 Self-reported allergy; CESC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg05132306 chr1:1846340 CALML6 0.3 6.38 0.36 7.91e-10 Body mass index; CESC cis rs17401966 0.867 rs12403443 chr1:10423988 A/G cg15208524 chr1:10270712 KIF1B 0.44 5.47 0.32 1.05e-7 Hepatocellular carcinoma; CESC cis rs244293 0.700 rs12939352 chr17:53007655 T/G cg19360675 chr17:53046073 COX11;STXBP4 -0.47 -6.35 -0.36 9.11e-10 Menarche (age at onset); CESC cis rs4969178 0.965 rs16971105 chr17:76393975 G/T cg05887092 chr17:76393375 PGS1 0.58 9.19 0.49 1.22e-17 HDL cholesterol levels; CESC cis rs7809950 0.954 rs2894466 chr7:107242909 G/A cg23024343 chr7:107201750 COG5 0.46 6.24 0.36 1.76e-9 Coronary artery disease; CESC cis rs644799 0.763 rs2950521 chr11:95536870 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.13 0.49 1.83e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg16339924 chr4:17578868 LAP3 0.65 8.37 0.46 3.25e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2637266 0.905 rs4357630 chr10:78382883 T/G cg18941641 chr10:78392320 NA 0.39 7.49 0.42 1.02e-12 Pulmonary function; CESC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg10862848 chr6:42927986 GNMT -0.26 -6.53 -0.37 3.42e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4594175 0.926 rs4901083 chr14:51604998 C/A cg23942311 chr14:51606299 NA 0.4 5.94 0.34 9.07e-9 Cancer; CESC cis rs1545257 0.537 rs11125582 chr2:24646213 C/T cg06627628 chr2:24431161 ITSN2 -0.51 -5.98 -0.35 7.04e-9 Sjögren's syndrome; CESC cis rs6433857 0.536 rs12474658 chr2:181352992 G/T cg23363182 chr2:181467187 NA -0.4 -5.61 -0.33 5.08e-8 Body mass index; CESC cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.08 10.85 0.55 6.1e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7178572 0.568 rs12906708 chr15:77681444 A/G cg22256960 chr15:77711686 NA -0.54 -6.95 -0.39 2.9e-11 Type 2 diabetes; CESC cis rs9303401 0.538 rs8078280 chr17:56473132 A/G cg25039879 chr17:56429692 SUPT4H1 0.58 6.03 0.35 5.36e-9 Cognitive test performance; CESC trans rs61931739 0.534 rs28548399 chr12:34188151 G/A cg13010199 chr12:38710504 ALG10B 0.48 5.99 0.35 6.66e-9 Morning vs. evening chronotype; CESC cis rs6542838 0.702 rs6419564 chr2:99534113 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.2 -0.3 4.06e-7 Fear of minor pain; CESC cis rs2635047 0.967 rs2576060 chr18:44637106 C/T cg19077165 chr18:44547161 KATNAL2 0.51 6.98 0.39 2.34e-11 Educational attainment; CESC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -8.13 -0.45 1.64e-14 Gut microbiome composition (summer); CESC cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg26769984 chr7:1090371 C7orf50 0.6 6.16 0.35 2.74e-9 Bronchopulmonary dysplasia; CESC cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9682041 0.696 rs35177863 chr3:170090006 A/G cg11886554 chr3:170076028 SKIL 0.7 6.49 0.37 4.1e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg12564285 chr5:131593104 PDLIM4 0.38 5.8 0.34 1.92e-8 Acylcarnitine levels; CESC cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs11725477 chr4:98803266 G/T cg17366294 chr4:99064904 C4orf37 0.58 8.12 0.45 1.73e-14 Colonoscopy-negative controls vs population controls; CESC cis rs7296418 0.754 rs1619283 chr12:123717362 A/G cg00376283 chr12:123451042 ABCB9 0.66 9.19 0.49 1.18e-17 Platelet count; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg23311108 chr5:115387951 NA -0.44 -6.48 -0.37 4.52e-10 Thyroid stimulating hormone; CESC cis rs28386778 0.700 rs12449555 chr17:62003982 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.98 -15.64 -0.69 1.61e-39 Prudent dietary pattern; CESC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.58 -0.37 2.56e-10 Bipolar disorder; CESC cis rs11792861 0.926 rs1044905 chr9:111781495 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.47 5.98 0.34 7.2e-9 Menarche (age at onset); CESC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg05754148 chr16:3507555 NAT15 -0.47 -6.9 -0.39 3.92e-11 Tuberculosis; CESC cis rs7267979 0.966 rs6107031 chr20:25350677 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.88e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs854765 0.506 rs7210400 chr17:17949957 C/T cg04398451 chr17:18023971 MYO15A 0.71 10.43 0.54 1.44e-21 Total body bone mineral density; CESC trans rs459571 0.876 rs2520095 chr9:136919568 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.67 -8.83 -0.48 1.48e-16 Platelet distribution width; CESC trans rs61931739 0.534 rs11053000 chr12:34079022 C/T cg26384229 chr12:38710491 ALG10B 0.6 8.36 0.46 3.5e-15 Morning vs. evening chronotype; CESC cis rs7927771 0.524 rs10838777 chr11:47860954 A/C cg18512352 chr11:47633146 NA 0.35 5.37 0.31 1.7e-7 Subjective well-being; CESC cis rs2932538 0.961 rs1238 chr1:113214097 G/A cg22162597 chr1:113214053 CAPZA1 -0.56 -7.11 -0.4 1.1e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs616402 0.527 rs11121581 chr1:10577740 A/G cg07384165 chr1:10488281 NA -0.59 -8.65 -0.47 5.18e-16 Breast size; CESC trans rs2121875 0.667 rs10941659 chr5:44223360 A/T cg07292773 chr6:156718177 NA -0.47 -6.09 -0.35 3.99e-9 Prostate cancer; CESC cis rs2243480 1.000 rs1964692 chr7:65454183 G/A cg18252515 chr7:66147081 NA -1.19 -11.57 -0.58 2.56e-25 Diabetic kidney disease; CESC cis rs3740713 1.000 rs73438686 chr11:18459785 C/T cg23797887 chr11:18477753 LDHAL6A -0.55 -5.21 -0.3 3.87e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs3809863 0.602 rs6504833 chr17:45396087 A/G cg08085267 chr17:45401833 C17orf57 -0.71 -9.66 -0.51 4.27e-19 Glaucoma (primary open-angle); CESC cis rs3820068 0.603 rs7531396 chr1:15969870 G/C cg17385448 chr1:15911702 AGMAT 0.42 6.76 0.38 8.54e-11 Systolic blood pressure; CESC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.79 0.39 7.29e-11 Bipolar disorder; CESC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg19774624 chr17:42201019 HDAC5 -0.91 -14.94 -0.68 5.18e-37 Total body bone mineral density; CESC cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.19 0.3 4.29e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7937682 0.889 rs542424 chr11:111477698 T/C cg22437258 chr11:111473054 SIK2 0.71 9.58 0.51 7.18e-19 Primary sclerosing cholangitis; CESC cis rs910316 1.000 rs7145159 chr14:75583268 A/G cg08847533 chr14:75593920 NEK9 1.0 19.2 0.76 4.31e-52 Height; CESC cis rs9457247 0.663 rs9459835 chr6:167417551 G/T cg07741184 chr6:167504864 NA 0.34 5.96 0.34 7.8e-9 Crohn's disease; CESC cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg23158103 chr7:148848205 ZNF398 -0.41 -6.46 -0.37 4.89e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4853012 0.887 rs2280644 chr2:74358411 G/A cg05776053 chr2:74358815 NA 0.42 5.17 0.3 4.65e-7 Gestational age at birth (maternal effect); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19902122 chr11:1087601 MUC2 0.48 6.49 0.37 4.23e-10 Fibrinogen levels; CESC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg26939375 chr7:64535504 NA 0.77 10.71 0.55 1.83e-22 Aortic root size; CESC cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg11366901 chr6:160182831 ACAT2 0.8 9.85 0.52 1.05e-19 Age-related macular degeneration (geographic atrophy); CESC trans rs7819412 0.623 rs7833435 chr8:10801137 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -6.41 -0.37 6.53e-10 Triglycerides; CESC cis rs9900062 0.586 rs6504249 chr17:62676149 A/G cg02097616 chr17:62675921 NA 0.43 5.2 0.3 3.93e-7 QT interval; CESC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg12718519 chr1:2058417 PRKCZ 0.25 5.24 0.31 3.21e-7 Height; CESC cis rs6500602 0.739 rs4786502 chr16:4537104 T/C cg08645402 chr16:4508243 NA 0.57 8.99 0.48 4.75e-17 Schizophrenia; CESC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.32 -5.53 -0.32 7.81e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15572692 chr19:14016919 C19orf57;CC2D1A 0.58 6.8 0.39 7.12e-11 Gut microbiome composition (summer); CESC cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg05315796 chr3:52349193 DNAH1 -0.28 -5.08 -0.3 7.09e-7 Electroencephalogram traits; CESC cis rs10911232 0.507 rs4397624 chr1:183053131 C/T ch.1.3577855R chr1:183094577 LAMC1 0.85 13.7 0.64 1.21e-32 Hypertriglyceridemia; CESC cis rs3015497 0.603 rs12882292 chr14:51018362 G/A cg26011998 chr14:51135199 SAV1 0.47 5.36 0.31 1.8e-7 Mean platelet volume; CESC cis rs11051970 0.659 rs73088096 chr12:32584403 G/T cg24626660 chr12:32551988 NA 0.36 5.14 0.3 5.42e-7 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10601968 chr5:137090200 HNRNPA0 0.59 7.37 0.41 2.17e-12 Gut microbiome composition (summer); CESC trans rs3942852 0.774 rs10838811 chr11:48186795 A/G cg03929089 chr4:120376271 NA -0.66 -7.13 -0.4 9.73e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs4253772 0.550 rs6007779 chr22:46678615 A/C cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.57 6.04 0.35 5.16e-9 LDL cholesterol;Cholesterol, total; CESC cis rs11690935 0.959 rs10204622 chr2:172588982 C/T cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.97 -0.68 4e-37 Schizophrenia; CESC cis rs11190604 1.000 rs2489036 chr10:102319581 A/G cg07080220 chr10:102295463 HIF1AN 0.62 5.9 0.34 1.1e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs568617 0.953 rs1151519 chr11:65645831 G/C cg19792802 chr11:65647270 CTSW -0.35 -5.31 -0.31 2.33e-7 Crohn's disease; CESC cis rs9868809 0.881 rs13076269 chr3:48675925 T/C cg07636037 chr3:49044803 WDR6 -0.64 -5.22 -0.31 3.66e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg24250549 chr1:154909240 PMVK 0.74 11.09 0.56 1.01e-23 Prostate cancer; CESC cis rs6121246 0.909 rs6089070 chr20:30377773 A/G cg13852791 chr20:30311386 BCL2L1 -0.85 -7.78 -0.43 1.65e-13 Mean corpuscular hemoglobin; CESC cis rs2204008 0.728 rs11495375 chr12:38282631 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.26 0.53 5.3e-21 Bladder cancer; CESC cis rs9790314 1.000 rs7653361 chr3:160992291 C/T cg03342759 chr3:160939853 NMD3 -0.45 -5.9 -0.34 1.08e-8 Morning vs. evening chronotype; CESC cis rs4523957 0.651 rs1994883 chr17:2083881 T/A cg16513277 chr17:2031491 SMG6 -0.71 -10.17 -0.53 1.04e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6076065 0.775 rs6083114 chr20:23379528 G/T cg11657817 chr20:23433608 CST11 0.41 6.23 0.36 1.8e-9 Facial morphology (factor 15, philtrum width); CESC cis rs1559088 0.600 rs7256470 chr19:33558085 C/A cg17764715 chr19:33622953 WDR88 0.59 8.34 0.46 4.12e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs7246760 1.000 rs2081066 chr19:9928044 C/T cg02900749 chr2:68251473 NA -0.73 -6.71 -0.38 1.15e-10 Pursuit maintenance gain; CESC cis rs61784830 0.710 rs61783251 chr1:46368087 G/C cg03146154 chr1:46216737 IPP 0.69 5.59 0.33 5.51e-8 Iron status biomarkers (total iron binding capacity); CESC cis rs2694528 0.686 rs6864253 chr5:59862743 A/G cg11474532 chr5:59995715 DEPDC1B 0.77 5.83 0.34 1.57e-8 Parkinson's disease; CESC cis rs11792861 0.926 rs3750451 chr9:111822866 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 5.38 0.31 1.62e-7 Menarche (age at onset); CESC cis rs367615 0.918 rs4576198 chr5:108867350 T/G cg17395555 chr5:108820864 NA 0.57 8.44 0.46 2.07e-15 Colorectal cancer (SNP x SNP interaction); CESC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg13628971 chr7:2884303 GNA12 0.62 8.24 0.45 8.19e-15 Height; CESC cis rs9325144 0.723 rs10161183 chr12:39182087 T/C cg26384229 chr12:38710491 ALG10B -0.51 -7.23 -0.41 5.23e-12 Morning vs. evening chronotype; CESC cis rs9788682 1.000 rs7163730 chr15:78814681 A/G cg24631222 chr15:78858424 CHRNA5 0.76 9.71 0.51 2.79e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg12963246 chr6:28129442 ZNF389 0.49 6.48 0.37 4.43e-10 Parkinson's disease; CESC cis rs897984 0.683 rs9932572 chr16:30841642 A/G cg00531865 chr16:30841666 NA -0.58 -8.64 -0.47 5.32e-16 Dementia with Lewy bodies; CESC cis rs18122 0.632 rs1483335 chr2:67526287 C/A cg09028215 chr2:67624308 ETAA1 -0.41 -5.17 -0.3 4.53e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7937682 0.883 rs1784776 chr11:111472392 C/T cg22437258 chr11:111473054 SIK2 0.74 9.86 0.52 9.59e-20 Primary sclerosing cholangitis; CESC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.71e-16 Initial pursuit acceleration; CESC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg02187348 chr16:89574699 SPG7 0.63 8.87 0.48 1.11e-16 Multiple myeloma (IgH translocation); CESC cis rs4474465 1.000 rs6592779 chr11:78197283 G/C cg02023728 chr11:77925099 USP35 0.39 5.05 0.3 8.34e-7 Alzheimer's disease (survival time); CESC trans rs11098499 0.954 rs6838814 chr4:120392443 G/A cg25214090 chr10:38739885 LOC399744 0.71 10.27 0.53 4.75e-21 Corneal astigmatism; CESC cis rs919433 0.889 rs787995 chr2:198216853 T/G cg10820045 chr2:198174542 NA 0.39 5.78 0.33 2.05e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs1559777 0.702 rs8037239 chr15:58098521 T/A cg05133900 chr22:19166543 SLC25A1 -0.6 -6.08 -0.35 4.24e-9 Myopia (pathological); CESC trans rs6828577 0.862 rs298992 chr4:119641941 A/T cg05098011 chr1:151736092 OAZ3;MRPL9 -0.49 -6.08 -0.35 4.27e-9 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg08888203 chr3:10149979 C3orf24 0.51 6.51 0.37 3.85e-10 Alzheimer's disease; CESC cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg27398817 chr8:82754497 SNX16 0.56 6.44 0.37 5.68e-10 Diastolic blood pressure; CESC cis rs6691722 0.503 rs6692646 chr1:24707629 C/T cg02336364 chr1:24764700 NIPAL3 0.32 6.58 0.37 2.48e-10 Response to interferon beta in multiple sclerosis; CESC cis rs72945132 0.882 rs7932431 chr11:70166059 A/T cg14191688 chr11:70257035 CTTN 0.43 5.46 0.32 1.08e-7 Coronary artery disease; CESC cis rs9894429 0.646 rs12948797 chr17:79617384 G/A cg13777783 chr17:79615861 NA -0.32 -5.32 -0.31 2.19e-7 Eye color traits; CESC cis rs4727027 0.933 rs2158633 chr7:148832652 C/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.92 -0.39 3.31e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17327406 chr4:6303265 WFS1 -0.65 -7.16 -0.4 7.82e-12 Gut microbiome composition (summer); CESC cis rs3820928 0.967 rs12622456 chr2:227768868 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -5.9 -0.34 1.11e-8 Pulmonary function; CESC cis rs939658 0.776 rs35382567 chr15:79440897 C/T cg17916960 chr15:79447300 NA -0.35 -5.98 -0.34 7.25e-9 Refractive error; CESC cis rs7267979 0.966 rs2387882 chr20:25378802 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.4e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs6831352 1.000 rs6822348 chr4:100053894 A/T cg13256891 chr4:100009986 ADH5 0.72 8.3 0.45 5.2e-15 Alcohol dependence; CESC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg08470875 chr2:26401718 FAM59B -0.48 -5.21 -0.31 3.72e-7 Gut microbiome composition (summer); CESC cis rs7621025 0.500 rs4678275 chr3:136653683 C/T cg15507776 chr3:136538369 TMEM22 0.78 9.68 0.51 3.46e-19 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs1048238 0.506 rs12023422 chr1:16187625 G/A cg22431228 chr1:16359049 CLCNKA -0.36 -6.23 -0.36 1.83e-9 Systolic blood pressure; CESC cis rs1878931 0.582 rs27238 chr16:3441223 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.7 -8.33 -0.46 4.29e-15 Body mass index (adult); CESC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg11764359 chr7:65958608 NA 0.78 9.86 0.52 9.96e-20 Aortic root size; CESC cis rs1448094 0.511 rs4462416 chr12:86150966 T/C cg02569458 chr12:86230093 RASSF9 -0.42 -6.46 -0.37 4.89e-10 Major depressive disorder; CESC cis rs10751667 0.600 rs6597948 chr11:1005308 C/T cg06064525 chr11:970664 AP2A2 -0.32 -5.44 -0.32 1.19e-7 Alzheimer's disease (late onset); CESC cis rs6060717 0.610 rs2244883 chr20:34620896 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -7.74 -0.43 2.08e-13 Hip circumference adjusted for BMI; CESC cis rs9388451 0.772 rs1268064 chr6:126042578 G/A cg10911889 chr6:126070802 HEY2 -0.37 -5.29 -0.31 2.53e-7 Brugada syndrome; CESC cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg18490616 chr2:88469792 THNSL2 -0.46 -6.59 -0.38 2.34e-10 Response to metformin (IC50); CESC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.36 -0.31 1.82e-7 Lung cancer; CESC cis rs4964805 0.657 rs4964814 chr12:104189384 A/C cg02344784 chr12:104178138 NT5DC3 -0.46 -6.49 -0.37 4.2e-10 Attention deficit hyperactivity disorder; CESC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.61 0.38 2.16e-10 Bipolar disorder; CESC cis rs2066819 1.000 rs78121408 chr12:56684798 C/T cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs2243480 1.000 rs422164 chr7:65586605 C/G cg18252515 chr7:66147081 NA -1.41 -14.36 -0.66 5.44e-35 Diabetic kidney disease; CESC cis rs1050631 0.564 rs1785904 chr18:33713132 T/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.51e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs8180040 0.966 rs17784882 chr3:47544003 C/A cg27129171 chr3:47204927 SETD2 -0.61 -8.75 -0.47 2.54e-16 Colorectal cancer; CESC cis rs2276314 0.857 rs9960670 chr18:33577712 A/G cg19628046 chr18:33552617 C18orf21 0.5 5.49 0.32 9.29e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs11792861 0.851 rs17552292 chr9:111891954 C/T cg05043794 chr9:111880884 C9orf5 -0.42 -6.94 -0.39 3.04e-11 Menarche (age at onset); CESC cis rs11690935 0.959 rs66835971 chr2:172677459 G/A cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.7 -0.67 3.66e-36 Schizophrenia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19419581 chr17:79482410 NA 0.54 7.13 0.4 9.33e-12 Systemic lupus erythematosus; CESC cis rs9911578 0.967 rs2567892 chr17:56668929 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -6.81 -0.39 6.37e-11 Intelligence (multi-trait analysis); CESC cis rs9430161 0.579 rs11121667 chr1:11038476 C/T cg02454025 chr1:11042201 C1orf127 0.89 14.7 0.67 3.45e-36 Ewing sarcoma; CESC cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg27398817 chr8:82754497 SNX16 -0.53 -6.14 -0.35 3.06e-9 Diastolic blood pressure; CESC cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.48 8.4 0.46 2.76e-15 Monocyte percentage of white cells; CESC cis rs727505 1.000 rs2402751 chr7:124434760 C/T cg23710748 chr7:124431027 NA -0.4 -5.93 -0.34 9.5e-9 Lewy body disease; CESC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg02038168 chr22:39784481 NA -0.61 -7.61 -0.42 4.76e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7659604 0.540 rs10001092 chr4:122677177 C/T cg19671926 chr4:122722719 EXOSC9 0.53 6.7 0.38 1.21e-10 Type 2 diabetes; CESC cis rs897080 0.515 rs1067319 chr2:44633458 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7659604 0.502 rs13108419 chr4:122687238 A/G cg19671926 chr4:122722719 EXOSC9 0.66 8.53 0.46 1.16e-15 Type 2 diabetes; CESC cis rs8044995 0.517 rs61593058 chr16:68384496 T/C cg26727032 chr16:67993705 SLC12A4 -0.54 -6.44 -0.37 5.52e-10 Schizophrenia; CESC cis rs329122 0.528 rs329114 chr5:133857708 C/G cg26284174 chr5:133860141 NA 0.46 5.29 0.31 2.52e-7 Body mass index;Type 2 diabetes; CESC cis rs9486715 1.000 rs11153085 chr6:97066355 A/T cg06623918 chr6:96969491 KIAA0776 -0.86 -12.58 -0.61 9.16e-29 Headache; CESC cis rs113835537 0.597 rs57288351 chr11:66307489 C/T cg22134325 chr11:66188745 NPAS4 0.39 5.86 0.34 1.37e-8 Airway imaging phenotypes; CESC cis rs644799 0.544 rs1622515 chr11:95523433 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.49 6.48 0.37 4.33e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12542094 chr19:2334761 SPPL2B 0.52 6.82 0.39 6.27e-11 Fibrinogen levels; CESC cis rs6714710 0.580 rs17489915 chr2:98420431 T/C cg26665480 chr2:98280029 ACTR1B 0.56 7.96 0.44 5.02e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs1801251 0.963 rs7591176 chr2:233581803 C/A cg08000102 chr2:233561755 GIGYF2 0.69 9.32 0.5 4.85e-18 Coronary artery disease; CESC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1707322 0.789 rs7540578 chr1:46252144 C/T cg03146154 chr1:46216737 IPP 0.79 11.19 0.57 4.58e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7607369 0.536 rs12990447 chr2:219667413 T/C cg02176678 chr2:219576539 TTLL4 -0.35 -6.13 -0.35 3.12e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs2302190 0.882 rs8067183 chr17:56462023 G/A cg25885038 chr17:56607967 SEPT4 -0.4 -5.42 -0.32 1.37e-7 Vitamin D levels; CESC cis rs4595586 0.545 rs7970850 chr12:39397878 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.44 5.9 0.34 1.08e-8 Bipolar disorder; CESC cis rs7188697 0.922 rs28307 chr16:58577138 A/C cg02549819 chr16:58548995 SETD6 -0.42 -5.21 -0.3 3.81e-7 QT interval; CESC cis rs1957429 0.731 rs10144554 chr14:65321514 T/G cg23373153 chr14:65346875 NA 0.85 8.91 0.48 8.47e-17 Pediatric areal bone mineral density (radius); CESC trans rs17807624 1.000 rs17807624 chr8:11463015 A/G cg15556689 chr8:8085844 FLJ10661 -0.56 -7.5 -0.42 9.48e-13 Systemic lupus erythematosus; CESC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs910316 1.000 rs876403 chr14:75602834 A/T cg11812906 chr14:75593930 NEK9 0.9 15.43 0.69 9.11e-39 Height; CESC cis rs6089584 0.507 rs28545731 chr20:60634102 C/T cg06108461 chr20:60628389 TAF4 -0.61 -8.11 -0.45 1.94e-14 Body mass index; CESC cis rs9858542 0.953 rs9862080 chr3:49674458 A/G cg03060546 chr3:49711283 APEH -0.57 -6.74 -0.38 9.8e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1003719 0.715 rs1981433 chr21:38542223 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.98 -0.44 4.49e-14 Eye color traits; CESC cis rs2243480 1.000 rs11538349 chr7:65421871 C/T cg18252515 chr7:66147081 NA -0.96 -9.28 -0.5 6.45e-18 Diabetic kidney disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02340378 chr2:73298299 SFXN5 -0.45 -6.42 -0.37 6.36e-10 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06383088 chr9:100459634 XPA 0.58 7.35 0.41 2.51e-12 Gut microbiome composition (summer); CESC cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg03433033 chr1:76189801 ACADM 0.7 8.56 0.47 9.39e-16 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2073300 1.000 rs6114098 chr20:23444276 G/A cg12062639 chr20:23401060 NAPB 0.77 5.68 0.33 3.48e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg07157834 chr1:205819609 PM20D1 0.68 9.83 0.52 1.2e-19 Menarche (age at onset); CESC cis rs1163251 0.902 rs514491 chr1:120216743 C/T cg19096424 chr1:120255104 PHGDH 0.43 5.22 0.31 3.62e-7 Blood metabolite levels; CESC cis rs992157 0.835 rs12987219 chr2:219144149 G/A cg00012203 chr2:219082015 ARPC2 -0.76 -9.76 -0.51 2.04e-19 Colorectal cancer; CESC cis rs7020830 0.867 rs563132 chr9:37245476 A/T cg14294708 chr9:37120828 ZCCHC7 1.2 22.07 0.8 5.6e-62 Schizophrenia; CESC cis rs936229 0.906 rs9210 chr15:75128501 T/C cg14664628 chr15:75095509 CSK -0.88 -12.21 -0.6 1.65e-27 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC trans rs2727020 0.538 rs61885230 chr11:49128958 T/C cg15704280 chr7:45808275 SEPT13 -0.63 -7.87 -0.44 9.15e-14 Coronary artery disease; CESC cis rs6089584 0.606 rs7270469 chr20:60577258 G/A cg24733560 chr20:60626293 TAF4 0.44 6.57 0.37 2.64e-10 Body mass index; CESC cis rs1538970 0.924 rs12046816 chr1:45891543 G/T cg24296786 chr1:45957014 TESK2 -0.46 -5.3 -0.31 2.41e-7 Platelet count; CESC cis rs36051895 0.632 rs7029084 chr9:5174638 T/C cg02405213 chr9:5042618 JAK2 -0.51 -6.54 -0.37 3.19e-10 Pediatric autoimmune diseases; CESC cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg22467129 chr15:76604101 ETFA -0.38 -5.75 -0.33 2.43e-8 Blood metabolite levels; CESC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 0.966 rs3827014 chr20:25371559 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.84e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16699022 chr16:89371566 ANKRD11 0.48 6.66 0.38 1.6e-10 Fibrinogen levels; CESC cis rs3126085 0.935 rs4845431 chr1:152227977 A/G cg03465714 chr1:152285911 FLG -0.46 -5.55 -0.32 6.76e-8 Atopic dermatitis; CESC cis rs933688 1.000 rs1363839 chr5:90671274 A/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.09 14.49 0.66 1.94e-35 Smoking behavior; CESC cis rs17376456 0.569 rs2045020 chr5:93224466 T/C cg25358565 chr5:93447407 FAM172A -0.72 -7.59 -0.42 5.32e-13 Diabetic retinopathy; CESC cis rs1577917 0.739 rs6922 chr6:86205323 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.58 7.83 0.43 1.14e-13 Response to antipsychotic treatment; CESC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.77 11.06 0.56 1.26e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs9768139 0.708 rs10234067 chr7:158114542 C/T cg24154853 chr7:158122151 PTPRN2 0.41 6.44 0.37 5.53e-10 Calcium levels; CESC cis rs17253792 0.822 rs78988988 chr14:56152404 G/A cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg08859206 chr1:53392774 SCP2 -0.68 -10.01 -0.52 3.33e-20 Monocyte count; CESC cis rs12479064 0.694 rs4341989 chr2:100046783 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.56 -6.91 -0.39 3.59e-11 Chronic sinus infection; CESC cis rs6500602 0.727 rs2058811 chr16:4575162 C/T cg08645402 chr16:4508243 NA 0.52 8.33 0.46 4.34e-15 Schizophrenia; CESC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg11764359 chr7:65958608 NA 0.8 10.12 0.53 1.42e-20 Aortic root size; CESC cis rs11958404 0.860 rs72818117 chr5:157441130 G/A cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs9911578 1.000 rs304270 chr17:56802141 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.34 -0.31 1.96e-7 Intelligence (multi-trait analysis); CESC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg04414720 chr1:150670196 GOLPH3L 0.52 6.81 0.39 6.62e-11 Melanoma; CESC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.91e-10 Bipolar disorder; CESC cis rs8077577 1.000 rs62073605 chr17:18066791 C/T cg16794390 chr17:18148240 FLII 0.46 6.0 0.35 6.43e-9 Obesity-related traits; CESC cis rs7267979 1.000 rs2257808 chr20:25266450 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs4722166 0.598 rs4722171 chr7:22785717 A/G cg05472934 chr7:22766657 IL6 0.86 10.84 0.55 6.66e-23 Lung cancer; CESC cis rs4925166 1 rs4925166 chr17:18210810 T/G cg08201673 chr17:18167551 SMCR7 0.5 5.73 0.33 2.78e-8 Multiple sclerosis; CESC cis rs7223966 1.000 rs8078462 chr17:61857937 T/G cg11494091 chr17:61959527 GH2 0.38 5.18 0.3 4.33e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs67311347 1.000 rs73078164 chr3:40480289 G/A cg24209194 chr3:40518798 ZNF619 0.5 6.21 0.36 2e-9 Renal cell carcinoma; CESC cis rs6500602 0.727 rs11076836 chr16:4569331 G/A cg08645402 chr16:4508243 NA 0.55 8.93 0.48 7.18e-17 Schizophrenia; CESC cis rs7147624 1.000 rs7160390 chr14:66052460 G/A cg03016385 chr14:66212404 NA -0.5 -5.21 -0.3 3.86e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9309473 0.950 rs10178678 chr2:73762236 A/G cg20560298 chr2:73613845 ALMS1 -0.54 -7.09 -0.4 1.19e-11 Metabolite levels; CESC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs722599 0.683 rs10144860 chr14:75286426 T/C cg08847533 chr14:75593920 NEK9 0.49 5.98 0.34 7.33e-9 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03020000 chr10:63662887 ARID5B -0.62 -7.66 -0.43 3.55e-13 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6456156 0.565 rs6921588 chr6:167494397 G/T cg23791538 chr6:167370224 RNASET2 -0.56 -6.77 -0.38 8.44e-11 Primary biliary cholangitis; CESC cis rs4233802 1.000 rs6761697 chr2:151141735 A/G cg25300694 chr2:151184358 NA 0.89 7.95 0.44 5.53e-14 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs854765 0.547 rs9897761 chr17:17912011 A/T cg16928487 chr17:17741425 SREBF1 -0.58 -10.22 -0.53 6.92e-21 Total body bone mineral density; CESC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg22903471 chr2:27725779 GCKR -0.54 -7.65 -0.43 3.75e-13 Total body bone mineral density; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg17408923 chr2:109335769 RANBP2 0.46 6.14 0.35 2.95e-9 Weight; CESC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.95 0.52 5.14e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6690583 0.623 rs1371141 chr1:85455372 C/A cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs6740322 0.793 rs9808360 chr2:43546835 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -7.5 -0.42 9.55e-13 Coronary artery disease; CESC cis rs10463316 0.862 rs10062928 chr5:150768355 C/T cg03212797 chr5:150827313 SLC36A1 -0.45 -5.88 -0.34 1.24e-8 Metabolite levels (Pyroglutamine); CESC cis rs11969893 0.850 rs12664068 chr6:101362098 G/T cg12253828 chr6:101329408 ASCC3 0.91 6.53 0.37 3.33e-10 Economic and political preferences (immigration/crime); CESC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg07701084 chr6:150067640 NUP43 0.48 6.69 0.38 1.29e-10 Lung cancer; CESC cis rs61935443 0.720 rs10859780 chr12:95282601 T/C cg21533806 chr12:95267307 NA 0.59 7.21 0.4 5.89e-12 Schizophrenia; CESC cis rs2742417 1.000 rs2742435 chr3:45740863 C/T cg10512202 chr3:45649293 LIMD1 0.38 5.21 0.3 3.85e-7 Response to anti-depressant treatment in major depressive disorder; CESC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg19193384 chr17:30244184 NA -0.56 -5.74 -0.33 2.61e-8 Hip circumference adjusted for BMI; CESC trans rs1814175 0.645 rs4625470 chr11:49983769 T/C cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs7818345 0.967 rs11784873 chr8:19281113 A/G cg11303988 chr8:19266685 CSGALNACT1 0.33 5.92 0.34 1.02e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs7520050 0.807 rs4660312 chr1:46110572 A/G cg24296786 chr1:45957014 TESK2 -0.46 -5.96 -0.34 8e-9 Red blood cell count;Reticulocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12476490 chr10:64576179 EGR2 0.49 6.88 0.39 4.42e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7662987 0.517 rs1154410 chr4:100006645 A/G cg13256891 chr4:100009986 ADH5 0.75 8.48 0.46 1.63e-15 Smoking initiation; CESC cis rs1044826 0.667 rs295471 chr3:139213922 G/C cg00490450 chr3:139108681 COPB2 0.44 5.46 0.32 1.11e-7 Obesity-related traits; CESC cis rs9467711 0.606 rs2076030 chr6:26426856 G/A cg14345882 chr6:26364793 BTN3A2 0.61 5.84 0.34 1.56e-8 Autism spectrum disorder or schizophrenia; CESC cis rs3892630 0.620 rs10413279 chr19:33182746 A/G cg22980127 chr19:33182716 NUDT19 1.08 15.02 0.68 2.62e-37 Red blood cell traits; CESC cis rs8017423 0.967 rs3825662 chr14:90723152 A/G cg14092571 chr14:90743983 NA -0.55 -8.31 -0.45 5.06e-15 Mortality in heart failure; CESC cis rs11190604 1.000 rs11190555 chr10:102209160 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.853 rs4821798 chr22:39021165 T/C cg06544989 chr22:39130855 UNC84B 0.51 9.33 0.5 4.42e-18 Menopause (age at onset); CESC cis rs2439831 0.702 rs495175 chr15:43798684 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.03 0.52 2.78e-20 Lung cancer in ever smokers; CESC cis rs477692 0.544 rs7904404 chr10:131447612 G/A cg05714579 chr10:131428358 MGMT -0.71 -9.8 -0.52 1.48e-19 Response to temozolomide; CESC cis rs4332037 0.539 rs57148375 chr7:2025001 G/C cg23422044 chr7:1970798 MAD1L1 -0.5 -5.38 -0.31 1.61e-7 Bipolar disorder; CESC trans rs79976124 0.797 rs79522358 chr6:66641140 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 8.26 0.45 6.99e-15 Type 2 diabetes; CESC cis rs1538970 0.781 rs34768551 chr1:46020408 G/A cg03146154 chr1:46216737 IPP 0.49 5.51 0.32 8.46e-8 Platelet count; CESC cis rs5769765 0.955 rs4075330 chr22:50303249 G/A cg02269571 chr22:50332266 NA -0.53 -6.77 -0.38 8.4e-11 Schizophrenia; CESC cis rs7772486 0.686 rs6570705 chr6:145961201 C/T cg23711669 chr6:146136114 FBXO30 0.88 13.05 0.63 2.12e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg16680214 chr1:154839983 KCNN3 -0.45 -6.81 -0.39 6.35e-11 Prostate cancer; CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg24642844 chr7:1081250 C7orf50 -0.4 -5.18 -0.3 4.33e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg14703610 chr5:56206110 C5orf35 0.4 5.13 0.3 5.56e-7 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18430553 chr17:78795541 RPTOR -0.5 -6.16 -0.35 2.63e-9 Gut microbiome composition (summer); CESC cis rs73206853 0.764 rs3026447 chr12:110724272 C/T cg12870014 chr12:110450643 ANKRD13A 0.61 5.3 0.31 2.42e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23087020 chr1:167190262 POU2F1 -0.44 -6.05 -0.35 4.95e-9 Asthma; CESC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg22907277 chr7:1156413 C7orf50 0.47 5.35 0.31 1.9e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12900413 0.523 rs11636525 chr15:90300478 A/G cg24249390 chr15:90295951 MESP1 -0.4 -5.35 -0.31 1.89e-7 Coronary artery aneurysm in Kawasaki disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18329780 chr15:57884048 GCOM1 0.58 6.87 0.39 4.52e-11 Gut microbiome composition (summer); CESC cis rs8077889 0.672 rs1234612 chr17:41840802 A/G cg26893861 chr17:41843967 DUSP3 1.02 19.14 0.76 7.06e-52 Triglycerides; CESC cis rs1008375 1.000 rs6811887 chr4:17640858 C/T cg16339924 chr4:17578868 LAP3 0.58 7.25 0.41 4.56e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 11.97 0.59 1.14e-26 Alzheimer's disease; CESC trans rs116095464 0.558 rs12173244 chr5:269524 G/A cg00938859 chr5:1591904 SDHAP3 0.63 6.88 0.39 4.31e-11 Breast cancer; CESC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg26314531 chr2:26401878 FAM59B -0.85 -9.04 -0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg11663144 chr21:46675770 NA -0.62 -9.64 -0.51 4.62e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg18252515 chr7:66147081 NA -0.45 -6.01 -0.35 5.99e-9 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19531713 chr17:41277059 BRCA1;NBR2 -0.49 -7.28 -0.41 3.7e-12 Gambling; CESC cis rs4835473 0.832 rs66717029 chr4:144658471 A/G cg25736465 chr4:144833511 NA -0.33 -5.25 -0.31 3.1e-7 Immature fraction of reticulocytes; CESC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg18876405 chr7:65276391 NA -0.57 -7.47 -0.42 1.14e-12 Aortic root size; CESC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg12963246 chr6:28129442 ZNF389 0.51 7.01 0.4 1.96e-11 Depression; CESC cis rs4969178 0.965 rs8075131 chr17:76394595 T/G cg20026190 chr17:76395443 PGS1 0.49 7.91 0.44 6.98e-14 HDL cholesterol levels; CESC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC cis rs2573652 0.722 rs8041337 chr15:100541808 T/C cg09918751 chr15:100517450 ADAMTS17 -0.32 -6.0 -0.35 6.36e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22628064 chr1:201489517 RPS10P7 -0.51 -6.24 -0.36 1.73e-9 Gut microbiome composition (summer); CESC cis rs11249608 0.548 rs2132671 chr5:178457434 A/G cg21905437 chr5:178450457 ZNF879 -0.58 -8.35 -0.46 3.76e-15 Pubertal anthropometrics; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13807351 chr1:212458736 PPP2R5A -0.47 -6.15 -0.35 2.83e-9 Gut microbiota (bacterial taxa); CESC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg04553112 chr3:125709451 NA -0.54 -5.85 -0.34 1.42e-8 Blood pressure (smoking interaction); CESC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg18305652 chr10:134549665 INPP5A 0.47 6.66 0.38 1.59e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs5753618 0.583 rs34545960 chr22:31812462 G/A cg13145458 chr22:31556086 RNF185 -0.5 -5.96 -0.34 7.96e-9 Colorectal cancer; CESC cis rs2228479 0.850 rs2238531 chr16:89856217 C/G cg06558623 chr16:89946397 TCF25 1.18 9.44 0.5 1.97e-18 Skin colour saturation; CESC cis rs9581857 0.547 rs9581881 chr13:28106637 A/G cg01674679 chr13:27998804 GTF3A -0.6 -5.06 -0.3 8.03e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs3749237 1.000 rs11717256 chr3:49868520 C/T cg03060546 chr3:49711283 APEH 0.65 7.65 0.43 3.69e-13 Resting heart rate; CESC cis rs10927875 0.619 rs2013019 chr1:16129320 T/C cg21385522 chr1:16154831 NA -0.75 -10.65 -0.55 2.82e-22 Dilated cardiomyopathy; CESC cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 4.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1003719 0.646 rs7276711 chr21:38578189 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.58e-15 Eye color traits; CESC cis rs2985684 0.846 rs11157693 chr14:50048426 T/C cg04989706 chr14:50066350 PPIL5 -0.45 -5.05 -0.3 8.24e-7 Carotid intima media thickness; CESC cis rs6912958 0.781 rs7757636 chr6:88256092 T/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -5.18 -0.3 4.31e-7 Monocyte percentage of white cells; CESC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg08027265 chr7:2291960 NA -0.49 -7.5 -0.42 9.45e-13 Bipolar disorder and schizophrenia; CESC cis rs914615 0.552 rs4276914 chr1:155142229 G/A cg02153340 chr1:155202674 NA -0.37 -5.39 -0.31 1.54e-7 Urinary albumin-to-creatinine ratio; CESC cis rs9300255 0.596 rs4460848 chr12:123677810 A/G cg00376283 chr12:123451042 ABCB9 0.67 9.28 0.5 6.47e-18 Neutrophil percentage of white cells; CESC trans rs1814175 0.676 rs1721999 chr11:49917372 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13078969 chr12:1799970 ADIPOR2 -0.56 -6.68 -0.38 1.4e-10 Gut microbiome composition (summer); CESC cis rs7086627 0.515 rs11202960 chr10:82209807 G/A cg00277334 chr10:82204260 NA -0.91 -15.92 -0.7 1.67e-40 Post bronchodilator FEV1; CESC cis rs12282928 0.617 rs11039638 chr11:48306990 T/G cg26585981 chr11:48327164 OR4S1 0.38 5.3 0.31 2.44e-7 Migraine - clinic-based; CESC cis rs2797160 1.000 rs1739352 chr6:126005310 T/C cg05901451 chr6:126070800 HEY2 -0.45 -6.53 -0.37 3.43e-10 Endometrial cancer; CESC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.41 -5.32 -0.31 2.24e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2652834 0.851 rs7170462 chr15:63345622 A/G cg05507819 chr15:63340323 TPM1 0.66 6.61 0.38 2.11e-10 HDL cholesterol; CESC cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg10556349 chr10:835070 NA 0.51 5.46 0.32 1.11e-7 Eosinophil percentage of granulocytes; CESC cis rs36051895 0.623 rs11790680 chr9:5248768 C/T cg02405213 chr9:5042618 JAK2 -0.55 -6.14 -0.35 3.01e-9 Pediatric autoimmune diseases; CESC cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg03467027 chr4:99064603 C4orf37 0.42 5.15 0.3 5.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6570726 0.905 rs375692 chr6:145840368 A/G cg05347473 chr6:146136440 FBXO30 0.42 5.75 0.33 2.43e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs704 0.523 rs11080054 chr17:26645991 G/A cg10342447 chr17:26645325 TMEM97 -0.42 -5.88 -0.34 1.22e-8 Osteoprotegerin levels; CESC cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg18876405 chr7:65276391 NA 0.65 8.56 0.47 9.4e-16 Aortic root size; CESC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg17178900 chr1:205818956 PM20D1 0.8 12.13 0.6 3.14e-27 Menarche (age at onset); CESC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg11764359 chr7:65958608 NA 0.67 8.67 0.47 4.34e-16 Calcium levels; CESC cis rs6076065 0.775 rs761723 chr20:23330720 A/G cg11657817 chr20:23433608 CST11 0.41 6.23 0.36 1.8e-9 Facial morphology (factor 15, philtrum width); CESC cis rs7586879 0.639 rs2033653 chr2:25103446 C/T cg01884057 chr2:25150051 NA -0.35 -6.73 -0.38 1.03e-10 Body mass index; CESC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.15 -0.4 8.21e-12 Developmental language disorder (linguistic errors); CESC cis rs637571 0.584 rs7107912 chr11:65603252 G/A cg26695010 chr11:65641043 EFEMP2 0.57 7.29 0.41 3.64e-12 Eosinophil percentage of white cells; CESC cis rs2228479 0.717 rs17226274 chr16:89850170 C/T cg06558623 chr16:89946397 TCF25 1.06 8.9 0.48 9.15e-17 Skin colour saturation; CESC cis rs6964587 0.620 rs7808587 chr7:91620096 G/A cg17063962 chr7:91808500 NA 0.46 6.49 0.37 4.16e-10 Breast cancer; CESC cis rs919433 0.927 rs1429418 chr2:198158151 G/C cg03934865 chr2:198174659 NA -0.41 -5.69 -0.33 3.36e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg19729930 chr2:74357872 NA 0.81 11.94 0.59 1.39e-26 Gestational age at birth (maternal effect); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg27660165 chr1:156784036 SH2D2A -0.45 -6.17 -0.35 2.6e-9 Height; CESC cis rs941873 0.803 rs2105461 chr10:81101679 A/G cg09469691 chr10:81107165 PPIF -0.57 -7.74 -0.43 2.1e-13 Height; CESC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg00149659 chr3:10157352 C3orf10 0.71 8.45 0.46 2.01e-15 Alzheimer's disease; CESC cis rs9790314 1.000 rs6441373 chr3:161026717 T/G cg04691961 chr3:161091175 C3orf57 -0.44 -5.73 -0.33 2.74e-8 Morning vs. evening chronotype; CESC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg22105103 chr4:187893119 NA 0.46 6.84 0.39 5.33e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs858239 0.699 rs955187 chr7:23194605 A/G cg23682824 chr7:23144976 KLHL7 -0.43 -5.8 -0.34 1.85e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.76e-28 Colonoscopy-negative controls vs population controls; CESC cis rs17601876 0.843 rs17523541 chr15:51554844 G/A cg19946085 chr15:51559439 CYP19A1 -0.33 -5.28 -0.31 2.69e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC trans rs6780666 0.509 rs4678306 chr3:136975979 C/T cg16900796 chr19:10755136 SLC44A2 -0.41 -6.36 -0.36 8.6e-10 Intelligence (multi-trait analysis); CESC cis rs13256369 1.000 rs4840351 chr8:8573148 A/G cg18904891 chr8:8559673 CLDN23 0.7 8.22 0.45 9.43e-15 Obesity-related traits; CESC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.23 -0.36 1.86e-9 Schizophrenia; CESC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.67 0.38 1.47e-10 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15774864 chr2:63272214 LOC100132215;EHBP1 -0.6 -6.54 -0.37 3.2e-10 Gut microbiome composition (summer); CESC cis rs3845702 0.877 rs12693216 chr2:180839793 T/A cg01881094 chr2:180872142 CWC22 -0.68 -7.29 -0.41 3.63e-12 Schizophrenia; CESC cis rs4722166 0.603 rs7801406 chr7:22788274 A/G cg13104385 chr7:22767384 IL6 0.47 6.25 0.36 1.59e-9 Lung cancer; CESC cis rs9926296 0.656 rs7191144 chr16:89823393 C/T cg04287289 chr16:89883240 FANCA 0.58 7.77 0.43 1.76e-13 Vitiligo; CESC cis rs10911363 0.592 rs12117885 chr1:183494214 C/T cg09173681 chr1:183549694 NCF2 -0.51 -7.49 -0.42 1.04e-12 Systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08722200 chr20:55960520 NA 0.46 6.11 0.35 3.52e-9 Fibrinogen levels; CESC cis rs2439831 0.867 rs12324572 chr15:43636200 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.73 0.55 1.57e-22 Lung cancer in ever smokers; CESC cis rs77106637 0.932 rs3814730 chr11:72555553 G/A cg03713592 chr11:72463424 ARAP1 1.12 10.02 0.52 3.01e-20 Type 2 diabetes; CESC cis rs36051895 0.659 rs7046511 chr9:5045695 C/T cg02405213 chr9:5042618 JAK2 -0.43 -5.31 -0.31 2.36e-7 Pediatric autoimmune diseases; CESC cis rs6977660 0.562 rs2189566 chr7:19768960 G/A cg05791153 chr7:19748676 TWISTNB 0.73 6.75 0.38 9.05e-11 Thyroid stimulating hormone; CESC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg07507251 chr3:52567010 NT5DC2 0.36 5.84 0.34 1.5e-8 Bipolar disorder; CESC cis rs6547741 0.935 rs4260197 chr2:27794150 C/G cg27432699 chr2:27873401 GPN1 -0.44 -6.2 -0.36 2.15e-9 Oral cavity cancer; CESC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.11 0.49 2.13e-17 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7264396 0.563 rs2425119 chr20:34324216 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.86 0.39 4.77e-11 Total cholesterol levels; CESC cis rs208520 0.526 rs9354366 chr6:66788559 C/T cg07460842 chr6:66804631 NA -1.11 -26.93 -0.86 8.11e-78 Exhaled nitric oxide output; CESC cis rs6558174 0.802 rs6558171 chr8:22487422 T/C cg03733263 chr8:22462867 KIAA1967 0.42 5.15 0.3 5.02e-7 Breast cancer; CESC cis rs2562152 0.613 rs216599 chr16:109671 A/G cg02949481 chr16:131562 MPG 0.62 6.27 0.36 1.46e-9 Glioblastoma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25312474 chr6:142468512 VTA1 -0.44 -6.7 -0.38 1.22e-10 Gambling; CESC cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg20307385 chr11:47447363 PSMC3 0.63 7.9 0.44 7.25e-14 Subjective well-being; CESC cis rs7481584 1.000 rs756693 chr11:3027889 A/G cg25174290 chr11:3078921 CARS -0.44 -5.44 -0.32 1.2e-7 Calcium levels; CESC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg08859206 chr1:53392774 SCP2 0.63 9.33 0.5 4.34e-18 Monocyte count; CESC cis rs6570726 0.935 rs384519 chr6:145846017 C/A cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 2e-26 Lobe attachment (rater-scored or self-reported); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg13665263 chr7:135662016 MTPN;LUZP6 -0.44 -6.32 -0.36 1.13e-9 Breast cancer; CESC cis rs13102973 0.835 rs4280795 chr4:135857246 T/A cg14419869 chr4:135874104 NA 0.33 5.13 0.3 5.5e-7 Subjective well-being; CESC cis rs7107174 0.786 rs4945266 chr11:78027488 A/G cg02023728 chr11:77925099 USP35 0.48 6.41 0.37 6.64e-10 Testicular germ cell tumor; CESC cis rs8070624 0.543 rs57728924 chr17:17875342 A/G cg09796270 chr17:17721594 SREBF1 0.43 5.68 0.33 3.48e-8 Total body bone mineral density; CESC cis rs116095464 0.614 rs62344339 chr5:252995 T/G cg10591111 chr5:226296 SDHA -0.51 -6.15 -0.35 2.84e-9 Breast cancer; CESC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs7091068 0.566 rs7909925 chr10:95507170 A/G cg20715218 chr10:95462985 C10orf4 0.61 6.0 0.35 6.31e-9 Urinary tract infection frequency; CESC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg04317338 chr11:64019027 PLCB3 -0.52 -6.39 -0.37 7.46e-10 Platelet count; CESC cis rs9303280 0.517 rs12939566 chr17:38038390 A/T cg20243544 chr17:37824526 PNMT 0.5 6.54 0.37 3.21e-10 Self-reported allergy; CESC cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg16339924 chr4:17578868 LAP3 0.65 8.32 0.45 4.76e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10911251 0.528 rs10911255 chr1:183088868 G/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.49e-35 Colorectal cancer; CESC cis rs2242116 0.796 rs4683297 chr3:46973673 T/C cg27129171 chr3:47204927 SETD2 -0.55 -6.97 -0.39 2.51e-11 Birth weight; CESC cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg09640425 chr7:158790006 NA -0.36 -5.56 -0.32 6.63e-8 Facial morphology (factor 20); CESC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg03188948 chr7:1209495 NA 0.73 7.05 0.4 1.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3925075 1.000 rs11859274 chr16:31361059 C/T cg02846316 chr16:31340340 ITGAM 0.42 6.56 0.37 2.86e-10 IgA nephropathy; CESC cis rs1144713 0.802 rs2652008 chr12:32246543 A/G cg01321189 chr12:32259338 BICD1 0.44 6.34 0.36 9.71e-10 Obesity-related traits; CESC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg08736216 chr1:53307985 ZYG11A -0.42 -7.0 -0.4 2.05e-11 Monocyte count; CESC cis rs1048238 0.846 rs945419 chr1:16344858 C/T cg22431228 chr1:16359049 CLCNKA -0.54 -10.94 -0.56 3.16e-23 Systolic blood pressure; CESC cis rs11785693 0.862 rs11774099 chr8:4988218 C/T cg26367366 chr8:4980734 NA 0.62 6.32 0.36 1.08e-9 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg13628971 chr7:2884303 GNA12 0.67 8.48 0.46 1.59e-15 Height; CESC cis rs708547 0.647 rs6843644 chr4:57891239 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.49 6.81 0.39 6.4e-11 Response to bleomycin (chromatid breaks); CESC cis rs2243480 1.000 rs68189316 chr7:65409169 C/G cg25894440 chr7:65020034 NA -0.59 -5.07 -0.3 7.57e-7 Diabetic kidney disease; CESC cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6032067 0.777 rs34916007 chr20:43782952 T/G cg10761708 chr20:43804764 PI3 0.55 6.51 0.37 3.7e-10 Blood protein levels; CESC cis rs7824557 0.527 rs2572376 chr8:11237756 C/A cg21775007 chr8:11205619 TDH -0.53 -8.05 -0.44 2.85e-14 Retinal vascular caliber; CESC trans rs853679 0.556 rs45509595 chr6:27840926 T/C cg01620082 chr3:125678407 NA -0.79 -6.42 -0.37 6.12e-10 Depression; CESC cis rs4974559 1.000 rs1882099 chr4:1352685 A/G cg02980000 chr4:1222292 CTBP1 0.57 6.66 0.38 1.54e-10 Systolic blood pressure; CESC cis rs1372520 0.935 rs1442152 chr4:90775649 C/A cg15133208 chr4:90757351 SNCA -0.37 -5.44 -0.32 1.18e-7 Neuroticism; CESC cis rs9811920 0.609 rs793465 chr3:99627750 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg09323728 chr8:95962352 TP53INP1 -0.45 -9.86 -0.52 9.98e-20 Type 2 diabetes; CESC cis rs939574 0.799 rs1109867 chr2:220083453 G/T cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.55 -5.26 -0.31 2.94e-7 Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13707777 chr5:308627 AHRR;PDCD6 -0.63 -7.58 -0.42 5.95e-13 Gut microbiome composition (summer); CESC cis rs2456568 0.867 rs10501810 chr11:93666589 C/G cg26875233 chr11:93583750 C11orf90 -0.29 -5.23 -0.31 3.48e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs67460515 0.563 rs11922957 chr3:160828865 A/C cg03342759 chr3:160939853 NMD3 -0.54 -6.87 -0.39 4.65e-11 Parkinson's disease; CESC cis rs2694528 0.686 rs7723165 chr5:59876715 A/G cg11474532 chr5:59995715 DEPDC1B 0.91 6.37 0.36 8.39e-10 Parkinson's disease; CESC cis rs17067123 1.000 rs17067113 chr4:180046510 C/G cg26610307 chr4:180072759 NA 0.56 6.22 0.36 1.91e-9 Response to hepatitis C treatment; CESC cis rs765787 0.530 rs2433227 chr15:45517119 A/T cg24006582 chr15:45444508 DUOX1 -0.58 -7.12 -0.4 1.04e-11 Uric acid levels; CESC cis rs644799 1.000 rs544119 chr11:95538624 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg23281280 chr6:28129359 ZNF389 -0.53 -7.18 -0.4 7.02e-12 Depression; CESC cis rs2230307 0.536 rs496798 chr1:100507990 G/A cg24955406 chr1:100503596 HIAT1 0.56 5.47 0.32 1.06e-7 Carotid intima media thickness; CESC cis rs8077577 0.747 rs2290505 chr17:18137141 A/G cg16794390 chr17:18148240 FLII -0.42 -6.38 -0.36 7.97e-10 Obesity-related traits; CESC cis rs2235544 0.550 rs12075159 chr1:54470234 A/G cg25741118 chr1:54482237 LDLRAD1 0.24 5.92 0.34 9.71e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs933688 1.000 rs933688 chr5:90762748 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.04 13.87 0.65 3.02e-33 Smoking behavior; CESC cis rs870825 0.550 rs28525282 chr4:185631468 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.0 0.4 2.05e-11 Blood protein levels; CESC cis rs9815354 0.812 rs58360908 chr3:41839837 A/G cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs8072100 0.817 rs12449647 chr17:45548958 C/A cg08085267 chr17:45401833 C17orf57 -0.58 -7.7 -0.43 2.77e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs460214 0.564 rs458465 chr21:40024644 A/T cg05519781 chr21:40033154 ERG -0.55 -7.86 -0.43 9.65e-14 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs9457247 0.967 rs443570 chr6:167389925 G/A cg07741184 chr6:167504864 NA 0.31 5.45 0.32 1.15e-7 Crohn's disease; CESC cis rs7524258 0.835 rs7521425 chr1:7306543 C/T cg07173049 chr1:7289937 CAMTA1 0.37 5.72 0.33 2.82e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs13256369 0.950 rs13255655 chr8:8577736 C/T cg18904891 chr8:8559673 CLDN23 0.65 7.05 0.4 1.51e-11 Obesity-related traits; CESC cis rs13095912 1.000 rs2034344 chr3:185337788 T/C cg11274856 chr3:185301563 NA 0.34 5.44 0.32 1.19e-7 Systolic blood pressure; CESC cis rs34779708 0.931 rs11596502 chr10:35387187 A/C cg04310649 chr10:35416472 CREM -0.49 -5.77 -0.33 2.15e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg22875332 chr1:76189707 ACADM 0.72 9.96 0.52 4.75e-20 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11098499 0.691 rs9996644 chr4:120238877 G/T cg25214090 chr10:38739885 LOC399744 0.59 8.08 0.44 2.33e-14 Corneal astigmatism; CESC cis rs8017423 0.934 rs11159952 chr14:90684874 T/C cg14092571 chr14:90743983 NA -0.58 -8.71 -0.47 3.4e-16 Mortality in heart failure; CESC cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.74 -10.56 -0.54 5.31e-22 Monocyte percentage of white cells; CESC cis rs34779708 0.733 rs11597184 chr10:35397396 G/A cg04310649 chr10:35416472 CREM -0.51 -6.17 -0.35 2.61e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs6546550 0.630 rs9309429 chr2:69995580 A/G cg02498382 chr2:70120550 SNRNP27 -0.32 -5.33 -0.31 2.11e-7 Prevalent atrial fibrillation; CESC cis rs11608355 0.545 rs7316375 chr12:109906998 G/C cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs2777491 0.915 rs8036498 chr15:41603276 A/G cg18705301 chr15:41695430 NDUFAF1 -0.6 -8.92 -0.48 7.87e-17 Ulcerative colitis; CESC cis rs6762 0.748 rs7928935 chr11:839127 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.76 -10.1 -0.53 1.69e-20 Mean platelet volume; CESC cis rs6747952 0.866 rs6726348 chr2:239084119 C/T cg17459225 chr2:239074497 NA 0.32 5.04 0.3 8.82e-7 Mean corpuscular hemoglobin concentration; CESC cis rs17001868 0.568 rs9611310 chr22:40733777 A/G cg07138101 chr22:40742427 ADSL 0.54 5.18 0.3 4.49e-7 Mammographic density (dense area); CESC cis rs11638352 1.000 rs2412852 chr15:44303086 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.66 -5.93 -0.34 9.18e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs7605827 0.930 rs59135666 chr2:15592448 G/A cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC cis rs6693567 0.565 rs834238 chr1:150366469 G/T cg09579323 chr1:150459698 TARS2 0.47 5.85 0.34 1.48e-8 Migraine; CESC cis rs6728642 0.808 rs113319086 chr2:97633267 G/C cg26665480 chr2:98280029 ACTR1B -0.88 -6.55 -0.37 3.05e-10 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs10465746 0.725 rs980417 chr1:84365331 C/A cg10977910 chr1:84465055 TTLL7 0.56 7.78 0.43 1.62e-13 Obesity-related traits; CESC cis rs12824058 0.831 rs4759450 chr12:130812732 G/A cg23887609 chr12:130822674 PIWIL1 0.44 5.7 0.33 3.2e-8 Menopause (age at onset); CESC cis rs6586111 0.967 rs6586110 chr10:82376492 G/A cg03086067 chr10:82368399 SH2D4B -0.28 -5.04 -0.3 8.62e-7 Capecitabine sensitivity; CESC cis rs1348850 0.519 rs1544002 chr2:178529534 C/T cg22681709 chr2:178499509 PDE11A -0.48 -6.87 -0.39 4.57e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg18099408 chr3:52552593 STAB1 -0.31 -5.19 -0.3 4.19e-7 Bipolar disorder; CESC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs6460942 0.597 rs6977059 chr7:12535157 T/G cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs1707322 1.000 rs4660895 chr1:46329739 C/T cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11098499 0.955 rs56386062 chr4:120155135 T/C cg25214090 chr10:38739885 LOC399744 0.65 8.59 0.47 7.54e-16 Corneal astigmatism; CESC trans rs2877832 0.841 rs72662391 chr14:27822340 G/T cg13449535 chr1:1101348 MIR200B 0.55 6.65 0.38 1.67e-10 Diabetes related insulin traits; CESC cis rs9527 0.590 rs763914 chr10:104841587 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.62 0.33 4.94e-8 Arsenic metabolism; CESC cis rs9300255 0.602 rs1727316 chr12:123618603 C/T cg00376283 chr12:123451042 ABCB9 0.7 8.7 0.47 3.5e-16 Neutrophil percentage of white cells; CESC cis rs1223629 1.000 rs11187800 chr10:95936892 A/G cg11276093 chr10:95123774 MYOF 0.58 5.08 0.3 7.06e-7 Glucose homeostasis traits; CESC cis rs7726839 0.561 rs72703046 chr5:580129 T/C cg09021430 chr5:549028 NA -0.43 -5.73 -0.33 2.68e-8 Obesity-related traits; CESC cis rs79387448 0.614 rs985523 chr2:102954376 G/A cg09003973 chr2:102972529 NA 1.13 8.98 0.48 5.2e-17 Gut microbiota (bacterial taxa); CESC cis rs2228479 0.850 rs62054224 chr16:89892071 C/T cg00800038 chr16:89945340 TCF25 -0.86 -6.88 -0.39 4.34e-11 Skin colour saturation; CESC cis rs7671266 0.668 rs10007416 chr4:10159457 T/C cg00071950 chr4:10020882 SLC2A9 -0.56 -6.0 -0.35 6.43e-9 Cardiovascular disease risk factors; CESC cis rs3105593 1.000 rs3131587 chr15:50845101 T/G cg08437265 chr15:50716283 USP8 0.42 5.48 0.32 9.88e-8 QT interval; CESC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg19468946 chr17:37922297 IKZF3 -0.42 -5.3 -0.31 2.42e-7 Glomerular filtration rate (creatinine); CESC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg10691866 chr7:65817282 TPST1 0.35 5.78 0.33 2.13e-8 Aortic root size; CESC cis rs7178909 0.872 rs3784387 chr15:90437370 G/A cg19708238 chr15:90437601 AP3S2 0.43 6.19 0.36 2.25e-9 Common traits (Other); CESC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg24308560 chr3:49941425 MST1R 0.6 8.72 0.47 3.17e-16 Body mass index; CESC cis rs7084402 0.967 rs12242287 chr10:60278340 A/G cg07615347 chr10:60278583 BICC1 -0.58 -9.39 -0.5 2.94e-18 Refractive error; CESC cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg24296786 chr1:45957014 TESK2 0.64 8.64 0.47 5.45e-16 High light scatter reticulocyte count; CESC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg13628971 chr7:2884303 GNA12 0.58 7.48 0.42 1.06e-12 Height; CESC cis rs9787249 0.957 rs3738673 chr1:40204823 C/T cg02773041 chr1:40204384 PPIE 0.54 7.73 0.43 2.17e-13 Blood protein levels; CESC cis rs66573146 0.572 rs68169399 chr4:6952491 T/A cg00086871 chr4:6988644 TBC1D14 1.03 6.83 0.39 5.93e-11 Granulocyte percentage of myeloid white cells; CESC cis rs4853012 1.000 rs4853012 chr2:74361290 G/A cg19729930 chr2:74357872 NA 0.91 11.31 0.57 1.91e-24 Gestational age at birth (maternal effect); CESC trans rs11098499 0.820 rs28578366 chr4:120536905 A/G cg25214090 chr10:38739885 LOC399744 -0.67 -9.25 -0.49 7.82e-18 Corneal astigmatism; CESC trans rs3741578 0.702 rs725956 chr12:57331936 A/G cg14720773 chr17:17603531 RAI1 0.48 6.46 0.37 4.9e-10 Asthma; CESC cis rs7178572 1.000 rs6495240 chr15:77766556 T/C cg22256960 chr15:77711686 NA -0.6 -8.09 -0.44 2.19e-14 Type 2 diabetes; CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg18538332 chr22:24372958 LOC391322 -0.76 -11.27 -0.57 2.6e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12477438 0.798 rs6704766 chr2:99642818 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.78 8.21 0.45 9.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg07414643 chr4:187882934 NA 0.55 7.6 0.42 4.98e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs4948102 0.642 rs4948104 chr7:56142519 A/G cg09872392 chr7:56161020 PHKG1 -0.45 -7.29 -0.41 3.48e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs9287719 0.967 rs2024431 chr2:10731327 A/G cg02196655 chr2:10830764 NOL10 -0.36 -5.57 -0.32 6.1e-8 Prostate cancer; CESC cis rs7527798 0.571 rs4844611 chr1:207827538 G/C cg21110645 chr1:207815933 NA -0.33 -5.88 -0.34 1.21e-8 Erythrocyte sedimentation rate; CESC cis rs11864453 0.793 rs7197453 chr16:72079127 G/C cg01557791 chr16:72042693 DHODH -0.62 -8.14 -0.45 1.54e-14 Fibrinogen levels; CESC cis rs2276314 0.802 rs4799838 chr18:33597530 T/C cg19628046 chr18:33552617 C18orf21 0.51 5.58 0.32 5.92e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs637571 0.522 rs528736 chr11:65705108 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 5.83 0.34 1.64e-8 Eosinophil percentage of white cells; CESC cis rs1707322 1.000 rs10789485 chr1:46407308 C/T cg03146154 chr1:46216737 IPP 0.78 10.77 0.55 1.17e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC cis rs910316 0.737 rs175072 chr14:75502827 T/C cg11812906 chr14:75593930 NEK9 -0.8 -13.04 -0.63 2.33e-30 Height; CESC trans rs853679 0.882 rs4713139 chr6:28092685 C/T cg06606381 chr12:133084897 FBRSL1 -0.66 -6.49 -0.37 4.14e-10 Depression; CESC cis rs910316 0.737 rs175080 chr14:75513828 G/A cg15467112 chr14:75489610 MLH3 -0.33 -5.1 -0.3 6.5e-7 Height; CESC cis rs672059 0.548 rs2480767 chr1:183257218 A/G ch.1.3577855R chr1:183094577 LAMC1 0.46 5.38 0.31 1.64e-7 Hypertriglyceridemia; CESC trans rs12310956 0.515 rs1830086 chr12:33958874 C/T cg26384229 chr12:38710491 ALG10B 0.59 8.35 0.46 3.79e-15 Morning vs. evening chronotype; CESC cis rs17376456 0.825 rs17314825 chr5:93234937 A/G cg25358565 chr5:93447407 FAM172A 1.06 10.5 0.54 8.89e-22 Diabetic retinopathy; CESC cis rs9815354 0.812 rs55682201 chr3:41848497 A/G cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6747952 0.899 rs4663856 chr2:239089624 C/A cg17459225 chr2:239074497 NA 0.34 5.39 0.31 1.58e-7 Mean corpuscular hemoglobin concentration; CESC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg07507251 chr3:52567010 NT5DC2 0.32 5.63 0.33 4.6e-8 Electroencephalogram traits; CESC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg00166722 chr3:10149974 C3orf24 0.53 6.62 0.38 2.02e-10 Alzheimer's disease; CESC cis rs202126107 1 rs202126107 chr17:38006767 GCATATTATA/G cg20243544 chr17:37824526 PNMT 0.48 6.39 0.37 7.58e-10 Eosinophil percentage of white cells; CESC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg16308533 chr17:40838983 CNTNAP1 0.51 8.12 0.45 1.81e-14 Colorectal or endometrial cancer; CESC cis rs1707322 1.000 rs4489497 chr1:46438698 C/T cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4699052 0.662 rs1516731 chr4:104252694 T/C cg16532752 chr4:104119610 CENPE -0.39 -5.47 -0.32 1.02e-7 Testicular germ cell tumor; CESC cis rs1670533 1.000 rs2045065 chr4:1052488 A/G cg27284194 chr4:1044797 NA 0.44 5.52 0.32 8.23e-8 Recombination rate (females); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21482489 chr5:121414366 LOX -0.58 -6.92 -0.39 3.37e-11 Gut microbiome composition (summer); CESC cis rs722599 0.683 rs7142898 chr14:75254310 A/T cg08847533 chr14:75593920 NEK9 0.49 5.98 0.34 7.06e-9 IgG glycosylation; CESC cis rs6964587 0.967 rs10231350 chr7:91808499 G/T cg17063962 chr7:91808500 NA 0.58 8.17 0.45 1.28e-14 Breast cancer; CESC cis rs9733 0.635 rs486836 chr1:150875967 A/T cg13175981 chr1:150552382 MCL1 0.53 7.04 0.4 1.6e-11 Tonsillectomy; CESC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg27170947 chr2:26402098 FAM59B -0.6 -7.25 -0.41 4.7e-12 Gut microbiome composition (summer); CESC cis rs11625487 0.957 rs10145540 chr14:77957354 C/T cg20045696 chr14:77926864 AHSA1 -0.62 -7.02 -0.4 1.88e-11 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC trans rs1941687 0.527 rs2000945 chr18:31365336 A/G cg27147174 chr7:100797783 AP1S1 -0.49 -6.64 -0.38 1.74e-10 Subjective well-being (multi-trait analysis);Subjective well-being; CESC cis rs6964587 0.869 rs7812219 chr7:91545727 C/T cg17063962 chr7:91808500 NA -0.55 -7.31 -0.41 3.19e-12 Breast cancer; CESC cis rs7208859 0.623 rs35916850 chr17:29011173 G/A cg14008862 chr17:28927542 LRRC37B2 0.73 5.82 0.34 1.67e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7617773 0.539 rs1471217 chr3:48384895 A/C cg11946769 chr3:48343235 NME6 0.66 8.34 0.46 4.12e-15 Coronary artery disease; CESC cis rs7923609 0.841 rs10740131 chr10:65271488 A/T cg01631684 chr10:65280961 REEP3 -0.42 -5.19 -0.3 4.1e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7589342 0.895 rs11901644 chr2:106432113 T/G cg16077055 chr2:106428750 NCK2 0.53 7.5 0.42 9.66e-13 Addiction; CESC trans rs1814175 0.615 rs12417290 chr11:49876951 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -18.65 -0.75 3.79e-50 Height; CESC cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09496791 chr2:95787596 MRPS5 0.47 6.05 0.35 4.94e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs17826219 0.561 rs11655876 chr17:29017150 G/A cg19761014 chr17:28927070 LRRC37B2 0.66 5.9 0.34 1.13e-8 Body mass index; CESC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg18876405 chr7:65276391 NA -0.52 -7.14 -0.4 8.86e-12 Aortic root size; CESC cis rs6598955 0.616 rs11247890 chr1:26590182 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.36 5.11 0.3 6.24e-7 Obesity-related traits; CESC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg25405998 chr7:65216604 CCT6P1 0.45 5.06 0.3 7.71e-7 Aortic root size; CESC cis rs926392 0.572 rs6129156 chr20:37672209 A/C cg16355469 chr20:37678765 NA 0.51 5.95 0.34 8.54e-9 Dialysis-related mortality; CESC cis rs12824058 0.831 rs11608407 chr12:130805869 G/A cg24838063 chr12:130822603 PIWIL1 0.61 8.02 0.44 3.32e-14 Menopause (age at onset); CESC cis rs12410462 0.581 rs35141785 chr1:227553496 G/C cg04117972 chr1:227635322 NA 0.63 5.46 0.32 1.09e-7 Major depressive disorder; CESC cis rs1044826 0.642 rs176983 chr3:139213755 G/A cg00490450 chr3:139108681 COPB2 0.42 5.08 0.3 7.25e-7 Obesity-related traits; CESC cis rs11630290 0.702 rs73444597 chr15:64126503 C/T cg12036633 chr15:63758958 NA -0.56 -5.21 -0.3 3.74e-7 Iris characteristics; CESC cis rs9430161 0.598 rs34350247 chr1:11034460 A/G cg27631724 chr1:11040367 C1orf127 0.38 6.14 0.35 2.99e-9 Ewing sarcoma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14906687 chr6:157099894 ARID1B -0.43 -6.05 -0.35 4.9e-9 Gambling; CESC cis rs9790314 0.967 rs1382427 chr3:161032576 T/C cg03342759 chr3:160939853 NMD3 -0.48 -6.25 -0.36 1.61e-9 Morning vs. evening chronotype; CESC cis rs11945232 1.000 rs6854710 chr4:88334640 A/G cg23841344 chr4:88312519 HSD17B11 -0.64 -8.08 -0.44 2.28e-14 Intelligence (multi-trait analysis); CESC cis rs9815354 0.812 rs73073234 chr3:42012071 C/T cg03022575 chr3:42003672 ULK4 0.68 6.13 0.35 3.21e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7216064 0.861 rs12449312 chr17:65829358 A/C cg12091567 chr17:66097778 LOC651250 -0.8 -8.71 -0.47 3.32e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.37 3.77e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg26408565 chr15:76604113 ETFA -0.37 -5.29 -0.31 2.56e-7 Blood metabolite levels; CESC trans rs6938574 0.813 rs17055223 chr6:128344785 C/T cg25774020 chr5:99869796 FAM174A -0.56 -6.27 -0.36 1.46e-9 Menarche (age at onset); CESC cis rs3947 0.789 rs1293322 chr8:11692638 C/T cg00262122 chr8:11665843 FDFT1 -0.52 -5.46 -0.32 1.11e-7 Blood protein levels; CESC cis rs7659604 0.502 rs10013916 chr4:122702179 T/G cg19671926 chr4:122722719 EXOSC9 0.66 8.73 0.47 2.96e-16 Type 2 diabetes; CESC cis rs763121 0.853 rs6001184 chr22:39052116 C/T cg14440974 chr22:39074834 NA -0.4 -5.49 -0.32 9.53e-8 Menopause (age at onset); CESC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.73 -9.22 -0.49 9.33e-18 Alzheimer's disease; CESC cis rs7927771 1.000 rs2290850 chr11:47807774 T/C cg05585544 chr11:47624801 NA -0.5 -7.74 -0.43 2.05e-13 Subjective well-being; CESC cis rs12681366 0.683 rs56285115 chr8:95401472 C/A cg13257157 chr8:95487014 RAD54B 0.38 5.14 0.3 5.22e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs9660992 0.674 rs72745221 chr1:205262337 G/A cg21643547 chr1:205240462 TMCC2 -0.47 -6.25 -0.36 1.6e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs921968 0.541 rs2241527 chr2:219537224 A/G cg02176678 chr2:219576539 TTLL4 0.56 9.2 0.49 1.08e-17 Mean corpuscular hemoglobin concentration; CESC cis rs8027181 0.797 rs8033580 chr15:72994968 C/A cg25632853 chr15:73088954 NA 0.31 5.41 0.32 1.38e-7 Triglyceride levels; CESC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg18446336 chr7:2847575 GNA12 -0.37 -5.76 -0.33 2.27e-8 Height; CESC cis rs1009170 0.794 rs2402112 chr14:92582172 G/A cg10324096 chr14:92587714 CPSF2;NDUFB1 0.55 5.11 0.3 6.15e-7 Dialysis-related mortality; CESC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg12373951 chr3:133503437 NA 0.42 6.0 0.35 6.56e-9 Iron status biomarkers; CESC cis rs7246657 0.943 rs2126977 chr19:37995747 C/G cg23950597 chr19:37808831 NA 0.48 5.34 0.31 2e-7 Coronary artery calcification; CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg24739457 chr1:205821442 NA 0.46 6.04 0.35 5.32e-9 Menarche (age at onset); CESC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg08888203 chr3:10149979 C3orf24 0.54 6.19 0.36 2.23e-9 Alzheimer's disease; CESC cis rs7267979 0.702 rs449801 chr20:25491847 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.72 12.08 0.6 4.73e-27 Liver enzyme levels (alkaline phosphatase); CESC cis rs11958404 0.932 rs72816587 chr5:157434144 T/A cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.4.71452R chr4:1726499 TACC3 -0.56 -6.76 -0.38 8.99e-11 Gut microbiome composition (summer); CESC cis rs12973672 0.812 rs12979792 chr19:35748706 A/G cg12095397 chr19:35769544 USF2 0.49 5.97 0.34 7.44e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12475106 chr4:503275 PIGG 0.56 7.6 0.42 5.09e-13 Fibrinogen levels; CESC trans rs801193 1.000 rs3857688 chr7:66127806 G/A cg26939375 chr7:64535504 NA -0.64 -8.57 -0.47 8.53e-16 Aortic root size; CESC cis rs6570726 1.000 rs6570699 chr6:145920732 G/A cg05347473 chr6:146136440 FBXO30 0.41 5.55 0.32 6.9e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7818688 1.000 rs73276417 chr8:96026312 C/G cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7223966 0.960 rs2854222 chr17:61939015 C/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.47 -5.86 -0.34 1.34e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs11155671 0.530 rs7763849 chr6:150206380 C/T cg09699651 chr6:150184138 LRP11 0.58 8.17 0.45 1.28e-14 Testicular germ cell tumor; CESC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg04025307 chr7:1156635 C7orf50 0.43 5.97 0.34 7.71e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6933660 0.536 rs3800274 chr6:151759192 T/G cg10883421 chr6:151773342 RMND1;C6orf211 0.67 8.55 0.47 9.7e-16 Menarche (age at onset); CESC cis rs926392 0.640 rs7268716 chr20:37693214 C/T cg16355469 chr20:37678765 NA 0.57 6.43 0.37 5.8e-10 Dialysis-related mortality; CESC cis rs853679 1.000 rs11965538 chr6:28239915 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.71 7.37 0.41 2.16e-12 Depression; CESC cis rs763121 0.719 rs138699 chr22:39129708 G/A cg06022373 chr22:39101656 GTPBP1 0.88 13.6 0.64 2.62e-32 Menopause (age at onset); CESC cis rs56046484 0.797 rs907260 chr15:85676757 G/A cg08123816 chr15:85640762 PDE8A 0.44 5.44 0.32 1.2e-7 Testicular germ cell tumor; CESC cis rs7107174 1.000 rs4945267 chr11:78037933 G/A cg02023728 chr11:77925099 USP35 0.52 6.86 0.39 4.74e-11 Testicular germ cell tumor; CESC cis rs8180040 0.871 rs11716661 chr3:47517773 G/T cg27129171 chr3:47204927 SETD2 -0.64 -9.6 -0.51 6.38e-19 Colorectal cancer; CESC cis rs7635838 0.892 rs3942925 chr3:11442921 T/C cg00170343 chr3:11313890 ATG7 0.42 5.5 0.32 8.99e-8 HDL cholesterol; CESC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg07308232 chr7:1071921 C7orf50 -0.45 -5.99 -0.35 6.73e-9 Longevity;Endometriosis; CESC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Tonsillectomy; CESC cis rs3820068 0.603 rs10492986 chr1:15988702 T/C cg13390004 chr1:15929781 NA 0.34 5.48 0.32 9.79e-8 Systolic blood pressure; CESC cis rs9513593 1.000 rs16956449 chr13:99966605 A/G cg21788972 chr13:99853209 UBAC2 0.62 7.17 0.4 7.32e-12 Psoriasis; CESC trans rs57221529 0.599 rs72707027 chr5:671294 C/G cg25482853 chr8:67687455 SGK3 0.97 9.47 0.5 1.67e-18 Lung disease severity in cystic fibrosis; CESC cis rs4843747 0.671 rs4075998 chr16:88106776 G/A cg03395651 chr16:88107091 BANP 0.46 5.36 0.31 1.85e-7 Menopause (age at onset); CESC cis rs6088590 0.965 rs6088620 chr20:33412022 A/G cg06115741 chr20:33292138 TP53INP2 0.6 7.51 0.42 9.05e-13 Coronary artery disease; CESC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg20271620 chr17:80763330 TBCD 0.46 5.43 0.32 1.27e-7 Breast cancer; CESC cis rs780096 0.587 rs4665969 chr2:27574953 C/T cg22903471 chr2:27725779 GCKR 0.48 6.89 0.39 3.96e-11 Total body bone mineral density; CESC cis rs7116495 0.609 rs4945378 chr11:71668866 G/A cg07596299 chr11:71824057 C11orf51 -0.76 -5.21 -0.3 3.77e-7 Severe influenza A (H1N1) infection; CESC cis rs11792861 0.926 rs11788904 chr9:111865052 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.41 5.12 0.3 5.97e-7 Menarche (age at onset); CESC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg07677032 chr17:61819896 STRADA 0.42 5.53 0.32 7.56e-8 Prudent dietary pattern; CESC cis rs2243480 1.000 rs10950032 chr7:65738591 C/A cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00746693 chr19:34746153 KIAA0355 0.54 6.02 0.35 5.87e-9 Gut microbiome composition (summer); CESC cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg19077165 chr18:44547161 KATNAL2 -0.61 -9.16 -0.49 1.46e-17 Personality dimensions; CESC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.42 7.06 0.4 1.45e-11 Personality dimensions; CESC cis rs1580019 0.534 rs13237495 chr7:32560687 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.66 0.38 1.57e-10 Cognitive ability; CESC cis rs7520050 0.966 rs10890354 chr1:46305347 G/A cg24296786 chr1:45957014 TESK2 0.44 5.54 0.32 7.22e-8 Red blood cell count;Reticulocyte count; CESC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.15e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6582630 0.519 rs12578283 chr12:38325349 A/T cg13010199 chr12:38710504 ALG10B 0.47 5.97 0.34 7.72e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg02038168 chr22:39784481 NA -0.57 -6.67 -0.38 1.46e-10 Intelligence (multi-trait analysis); CESC cis rs67311347 0.956 rs9822870 chr3:40514890 A/C cg01475735 chr3:40494733 NA 0.43 5.54 0.32 7.18e-8 Renal cell carcinoma; CESC cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg17191109 chr10:126851326 NA -0.41 -6.72 -0.38 1.12e-10 Menarche (age at onset); CESC cis rs873946 0.557 rs4880427 chr10:134591389 T/C cg18305652 chr10:134549665 INPP5A 0.45 6.14 0.35 2.95e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7584330 0.868 rs2325839 chr2:238386286 T/C cg14458575 chr2:238380390 NA 0.7 10.06 0.53 2.28e-20 Prostate cancer; CESC cis rs8078723 1.000 rs7214085 chr17:38169095 T/C cg17467752 chr17:38218738 THRA 0.67 9.97 0.52 4.3e-20 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg02753203 chr1:228287806 NA 0.53 7.88 0.44 8.34e-14 Diastolic blood pressure; CESC cis rs6582630 0.502 rs11514371 chr12:38306306 G/C cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs5753618 0.561 rs2413047 chr22:31666026 A/G cg13145458 chr22:31556086 RNF185 0.48 5.35 0.31 1.88e-7 Colorectal cancer; CESC trans rs35110281 0.807 rs28840140 chr21:45039163 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 6.69 0.38 1.34e-10 Mean corpuscular volume; CESC cis rs7771547 0.573 rs546272 chr6:36398562 G/A cg04289385 chr6:36355825 ETV7 0.36 5.19 0.3 4.23e-7 Platelet distribution width; CESC cis rs2439831 1.000 rs28666488 chr15:43741090 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.8 11.71 0.58 8.62e-26 Lung cancer in ever smokers; CESC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg18200150 chr17:30822561 MYO1D 0.71 10.69 0.55 2.07e-22 Schizophrenia; CESC cis rs9926296 0.706 rs2159115 chr16:89831819 A/G cg27121462 chr16:89883253 FANCA 0.51 6.19 0.36 2.27e-9 Vitiligo; CESC cis rs17376456 0.542 rs2043979 chr5:93120782 T/A cg25358565 chr5:93447407 FAM172A -0.47 -5.21 -0.3 3.8e-7 Diabetic retinopathy; CESC cis rs1775715 0.674 rs2778670 chr10:32161676 G/A cg18675610 chr10:32216311 ARHGAP12 0.35 5.38 0.31 1.6e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg17949981 chr6:28129498 ZNF389 0.45 5.56 0.32 6.54e-8 Depression; CESC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.09 -0.35 3.91e-9 Depression; CESC cis rs9640161 0.830 rs76741564 chr7:150059529 A/T cg21361702 chr7:150065534 REPIN1 0.67 8.26 0.45 6.87e-15 Blood protein levels;Circulating chemerin levels; CESC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg05368731 chr17:41323189 NBR1 0.79 11.08 0.56 1.1e-23 Menopause (age at onset); CESC cis rs8031584 1.000 rs35239376 chr15:31290538 A/C cg14829155 chr15:31115871 NA -0.74 -9.3 -0.5 5.63e-18 Huntington's disease progression; CESC cis rs6088590 1.000 rs6087626 chr20:33347328 C/T cg08999081 chr20:33150536 PIGU 0.58 8.95 0.48 6.2e-17 Coronary artery disease; CESC cis rs3749237 0.595 rs1464566 chr3:49459376 T/C cg03060546 chr3:49711283 APEH 0.77 11.7 0.58 9.27e-26 Resting heart rate; CESC cis rs765787 0.530 rs2433229 chr15:45515235 C/A cg24006582 chr15:45444508 DUOX1 -0.58 -7.11 -0.4 1.11e-11 Uric acid levels; CESC trans rs11165623 0.792 rs6671371 chr1:96977039 A/G cg10631902 chr5:14652156 NA -0.48 -7.0 -0.4 2.14e-11 Hip circumference;Waist circumference; CESC cis rs589448 0.967 rs634512 chr12:69754012 C/T cg20891283 chr12:69753455 YEATS4 1.0 17.3 0.73 2.24e-45 Cerebrospinal fluid biomarker levels; CESC trans rs208520 1.000 rs12192261 chr6:66985268 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.33 0.5 4.37e-18 Exhaled nitric oxide output; CESC cis rs7904368 0.806 rs4612698 chr10:16855070 C/A cg14835575 chr10:16859367 RSU1 0.53 5.4 0.31 1.5e-7 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs4664304 0.802 rs62175470 chr2:160858255 G/C cg03641300 chr2:160917029 PLA2R1 -0.5 -7.0 -0.39 2.16e-11 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05946335 chr7:66460663 SBDS;TYW1 0.59 7.02 0.4 1.81e-11 Gut microbiome composition (summer); CESC trans rs526821 0.595 rs629948 chr11:55356448 G/A cg03929089 chr4:120376271 NA -0.5 -6.07 -0.35 4.33e-9 Pediatric bone mineral density (spine); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19201477 chr8:21776851 XPO7 -0.48 -6.23 -0.36 1.77e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2072732 0.861 rs67919793 chr1:2954230 T/C cg03976712 chr1:2946727 NA 0.33 5.53 0.32 7.83e-8 Plateletcrit; CESC cis rs9790314 0.846 rs7652267 chr3:160998497 A/G cg03342759 chr3:160939853 NMD3 -0.53 -7.79 -0.43 1.48e-13 Morning vs. evening chronotype; CESC cis rs6546537 0.911 rs4852898 chr2:69872797 C/T cg10773587 chr2:69614142 GFPT1 -0.58 -6.52 -0.37 3.58e-10 Serum thyroid-stimulating hormone levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01102847 chr14:50053293 RPS29 0.56 6.19 0.36 2.23e-9 Gut microbiome composition (summer); CESC cis rs2439831 0.867 rs2920781 chr15:43924682 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.81 8.43 0.46 2.26e-15 Lung cancer in ever smokers; CESC cis rs7772486 0.875 rs2748482 chr6:146336532 T/C cg23711669 chr6:146136114 FBXO30 0.86 12.53 0.61 1.39e-28 Lobe attachment (rater-scored or self-reported); CESC trans rs1814175 0.817 rs4881627 chr11:49953955 C/A cg15704280 chr7:45808275 SEPT13 -1.03 -20.41 -0.78 2.75e-56 Height; CESC cis rs2072732 0.861 rs67630839 chr1:2951989 C/T cg03976712 chr1:2946727 NA 0.32 5.3 0.31 2.5e-7 Plateletcrit; CESC cis rs9911578 1.000 rs12449365 chr17:56600660 C/G cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.5e-11 Intelligence (multi-trait analysis); CESC cis rs8072100 0.934 rs8067286 chr17:45594590 A/G cg08085267 chr17:45401833 C17orf57 0.46 6.29 0.36 1.29e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs6089829 0.962 rs9679865 chr20:61666132 C/G cg23505145 chr19:12996616 KLF1 0.52 6.8 0.39 6.85e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs6714710 0.603 rs35505530 chr2:98506910 T/C cg26665480 chr2:98280029 ACTR1B 0.56 7.88 0.44 8.37e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.835 rs11077981 chr17:80147243 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.61e-7 Life satisfaction; CESC trans rs3780486 0.505 rs10117038 chr9:33122626 T/C cg04842962 chr6:43655489 MRPS18A 0.7 10.96 0.56 2.65e-23 IgG glycosylation; CESC cis rs2795502 1.000 rs2142991 chr10:43341105 C/T cg27426351 chr10:43362370 NA -0.48 -6.0 -0.35 6.51e-9 Blood protein levels; CESC cis rs806215 0.950 rs3757793 chr7:127225780 G/A cg25922125 chr7:127225783 GCC1 -0.49 -5.52 -0.32 8.22e-8 Type 2 diabetes; CESC cis rs7662987 0.517 rs1311618 chr4:100012612 A/G cg12011299 chr4:100065546 ADH4 0.61 6.71 0.38 1.17e-10 Smoking initiation; CESC cis rs778371 0.874 rs1083522 chr2:233745521 C/T cg08000102 chr2:233561755 GIGYF2 -0.83 -13.23 -0.63 4.96e-31 Schizophrenia; CESC cis rs11190604 1.000 rs12219158 chr10:102302923 T/C cg07080220 chr10:102295463 HIF1AN 0.66 6.04 0.35 5.08e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs5750830 0.594 rs9611165 chr22:39775250 A/G cg11247378 chr22:39784982 NA -0.51 -7.72 -0.43 2.36e-13 Intelligence (multi-trait analysis); CESC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg01570182 chr17:44337453 NA 0.86 10.02 0.52 2.93e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3780486 0.846 rs10971419 chr9:33124161 T/C cg13443165 chr9:33130375 B4GALT1 0.44 6.38 0.37 7.66e-10 IgG glycosylation; CESC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg17971929 chr21:40555470 PSMG1 -0.89 -12.71 -0.62 3.29e-29 Cognitive function; CESC cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg15017067 chr4:17643749 FAM184B 0.37 5.28 0.31 2.74e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg15664640 chr17:80829946 TBCD -0.63 -9.08 -0.49 2.57e-17 Breast cancer; CESC cis rs11098499 0.644 rs28787668 chr4:120554687 G/A cg24375607 chr4:120327624 NA 0.41 5.14 0.3 5.23e-7 Corneal astigmatism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05909553 chr8:145739024 RECQL4 0.47 7.18 0.4 7.08e-12 Fibrinogen levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09209803 chr6:33588932 ITPR3 -0.48 -6.08 -0.35 4.08e-9 Ulcerative colitis; CESC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg25072359 chr17:41440525 NA 0.45 6.13 0.35 3.21e-9 Menopause (age at onset); CESC cis rs7216064 1.000 rs12602912 chr17:65870073 C/T cg12091567 chr17:66097778 LOC651250 -0.85 -8.7 -0.47 3.61e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4654899 0.865 rs11807193 chr1:21420617 T/A cg05370193 chr1:21551575 ECE1 0.41 6.06 0.35 4.6e-9 Superior frontal gyrus grey matter volume; CESC cis rs28830936 0.625 rs8038764 chr15:41907905 A/C cg17847044 chr15:42102381 MAPKBP1 0.4 6.94 0.39 3.05e-11 Diastolic blood pressure; CESC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.34 0.41 2.69e-12 Bipolar disorder; CESC cis rs13095912 0.962 rs6785918 chr3:185330631 A/G cg11274856 chr3:185301563 NA 0.34 5.44 0.32 1.21e-7 Systolic blood pressure; CESC cis rs11792861 0.591 rs2275641 chr9:111696389 G/C cg13535736 chr9:111863775 C9orf5 -0.39 -5.62 -0.33 4.92e-8 Menarche (age at onset); CESC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg17294928 chr15:75287854 SCAMP5 0.49 6.51 0.37 3.82e-10 Breast cancer; CESC cis rs548181 0.545 rs76179820 chr11:125616379 A/G cg03464685 chr11:125439445 EI24 -0.65 -5.79 -0.34 1.99e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7223966 1.000 rs7220892 chr17:61908316 G/A cg11494091 chr17:61959527 GH2 0.38 5.19 0.3 4.25e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs365132 0.934 rs6861925 chr5:176324729 C/G cg16309518 chr5:176445507 NA -0.4 -5.96 -0.34 7.9e-9 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs7264396 0.790 rs3787164 chr20:34228866 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.56 0.42 6.68e-13 Total cholesterol levels; CESC cis rs7264396 0.563 rs6060560 chr20:34278890 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.9 -9.83 -0.52 1.23e-19 Total cholesterol levels; CESC cis rs12950390 0.853 rs17700008 chr17:45863591 A/C cg00777063 chr17:45855553 NA 0.36 5.26 0.31 2.91e-7 IgG glycosylation; CESC cis rs2652834 0.851 rs11071721 chr15:63350218 T/C cg05507819 chr15:63340323 TPM1 0.58 5.75 0.33 2.51e-8 HDL cholesterol; CESC cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg04455712 chr21:45112962 RRP1B 0.35 5.09 0.3 6.94e-7 Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26081613 chr14:71375319 PCNX -0.42 -6.11 -0.35 3.51e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs901683 1.000 rs12781186 chr10:46013438 A/G cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs6456156 0.716 rs6905911 chr6:167521624 C/T cg07741184 chr6:167504864 NA 0.31 5.19 0.3 4.23e-7 Primary biliary cholangitis; CESC cis rs7216064 0.531 rs6504573 chr17:66015963 C/T cg12091567 chr17:66097778 LOC651250 -0.7 -8.79 -0.48 1.94e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.93 0.39 3.16e-11 Electroencephalogram traits; CESC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.75 -10.67 -0.55 2.32e-22 Prudent dietary pattern; CESC cis rs41271473 0.687 rs7535661 chr1:228887667 C/T cg00850481 chr1:228891306 NA -0.44 -5.6 -0.33 5.46e-8 Chronic lymphocytic leukemia; CESC cis rs6032067 0.929 rs35880287 chr20:43821001 G/A cg11264863 chr20:43835661 SEMG1 0.49 5.29 0.31 2.5e-7 Blood protein levels; CESC cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg05347473 chr6:146136440 FBXO30 0.58 7.37 0.41 2.23e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2204008 0.744 rs2222344 chr12:38406832 T/G cg26384229 chr12:38710491 ALG10B 0.68 10.35 0.54 2.71e-21 Bladder cancer; CESC cis rs12220238 0.915 rs1908334 chr10:75991721 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.34 0.36 9.87e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs1355223 0.902 rs7129089 chr11:34699699 T/C cg11058730 chr11:34937778 PDHX;APIP -0.45 -6.02 -0.35 5.9e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9902453 0.874 rs4474741 chr17:28148117 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.63 -8.16 -0.45 1.4e-14 Coffee consumption (cups per day); CESC cis rs1707322 1.000 rs7531911 chr1:46330423 A/G cg05343316 chr1:45956843 TESK2 0.43 5.23 0.31 3.41e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg06641503 chr3:48959341 ARIH2 -0.33 -5.12 -0.3 6.02e-7 Parkinson's disease; CESC cis rs1023500 0.505 rs134901 chr22:42683520 C/T cg04733989 chr22:42467013 NAGA 0.64 9.7 0.51 3.15e-19 Schizophrenia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10558228 chr1:155533819 ASH1L -0.43 -6.29 -0.36 1.34e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4568518 0.501 rs12699920 chr7:17992949 T/C cg03009463 chr7:17980271 SNX13 0.45 5.88 0.34 1.21e-8 Measles; CESC cis rs7582720 1.000 rs76298043 chr2:203814694 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs3806843 1.000 rs1030165 chr5:140185448 G/A cg26395211 chr5:140044315 WDR55 -0.42 -5.26 -0.31 2.96e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6942756 0.774 rs2402944 chr7:128951402 G/T cg02491457 chr7:128862824 NA -0.62 -8.87 -0.48 1.11e-16 White matter hyperintensity burden; CESC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg07701084 chr6:150067640 NUP43 0.4 5.24 0.31 3.27e-7 Lung cancer; CESC cis rs7044106 0.762 rs1470307 chr9:123433039 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.85 14.07 0.65 5.96e-34 Hip circumference adjusted for BMI; CESC cis rs17539620 0.624 rs62432743 chr6:154836214 T/G cg20019720 chr6:154832845 CNKSR3 0.47 6.15 0.35 2.89e-9 Lipoprotein (a) levels; CESC cis rs2228479 0.717 rs9282682 chr16:89805794 A/G cg06558623 chr16:89946397 TCF25 0.71 6.64 0.38 1.74e-10 Skin colour saturation; CESC cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.85 8.48 0.46 1.59e-15 Schizophrenia; CESC cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg05234568 chr11:5960015 NA -0.63 -7.01 -0.4 2.03e-11 DNA methylation (variation); CESC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg15147215 chr3:52552868 STAB1 -0.31 -5.24 -0.31 3.36e-7 Electroencephalogram traits; CESC cis rs28647808 0.881 rs57394597 chr9:136261030 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs9309473 1.000 rs7582606 chr2:73813945 A/G cg20560298 chr2:73613845 ALMS1 -0.54 -7.1 -0.4 1.13e-11 Metabolite levels; CESC cis rs919433 1.000 rs7422899 chr2:198163527 G/C cg03934865 chr2:198174659 NA -0.41 -5.54 -0.32 7.33e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.63 0.47 5.76e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1538970 0.961 rs7553318 chr1:45843086 A/G cg05343316 chr1:45956843 TESK2 0.83 11.6 0.58 1.9e-25 Platelet count; CESC cis rs7508679 1.000 rs10410204 chr19:7224350 C/T cg00428638 chr19:7224713 INSR 0.49 7.69 0.43 2.87e-13 Hypothyroidism; CESC cis rs6084875 0.932 rs6084856 chr20:4728491 G/A cg05143360 chr20:4741328 NA 0.42 5.07 0.3 7.46e-7 Systemic lupus erythematosus; CESC cis rs941873 0.805 rs10762860 chr10:81117794 C/G cg11057378 chr10:81107060 PPIF 0.35 5.67 0.33 3.7e-8 Height; CESC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.47 -0.37 4.79e-10 Life satisfaction; CESC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg18402987 chr7:1209562 NA 0.76 7.58 0.42 5.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs2880765 0.835 rs56406982 chr15:86036379 G/A cg19183879 chr15:85880815 NA -0.25 -5.13 -0.3 5.74e-7 Coronary artery disease; CESC cis rs9790314 1.000 rs189270 chr3:161063504 T/C cg04691961 chr3:161091175 C3orf57 -0.42 -5.36 -0.31 1.8e-7 Morning vs. evening chronotype; CESC cis rs1707322 0.752 rs28719889 chr1:46202283 C/T cg05343316 chr1:45956843 TESK2 0.5 6.21 0.36 2.02e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26884921 chr19:50370748 PNKP 0.55 6.04 0.35 5.15e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21619287 chr16:3767727 TRAP1 0.63 7.15 0.4 8.32e-12 Gut microbiome composition (summer); CESC cis rs7474896 0.526 rs1742235 chr10:38052256 T/C cg00409905 chr10:38381863 ZNF37A -0.46 -5.03 -0.3 9.04e-7 Obesity (extreme); CESC trans rs1814175 0.867 rs7926002 chr11:49616018 A/G cg03929089 chr4:120376271 NA -0.84 -12.55 -0.61 1.19e-28 Height; CESC cis rs1355223 0.583 rs1549789 chr11:34867947 G/A cg11058730 chr11:34937778 PDHX;APIP 0.84 12.68 0.61 4.2e-29 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg05863683 chr7:1912471 MAD1L1 -0.4 -5.87 -0.34 1.27e-8 Bipolar disorder and schizophrenia; CESC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg04267008 chr7:1944627 MAD1L1 -0.71 -9.11 -0.49 2.06e-17 Bipolar disorder and schizophrenia; CESC cis rs3105593 0.563 rs8035851 chr15:50978042 C/A cg08437265 chr15:50716283 USP8 0.4 5.1 0.3 6.51e-7 QT interval; CESC cis rs1642645 0.831 rs6689536 chr1:42487523 T/C cg16685388 chr1:42384056 HIVEP3 0.37 5.61 0.33 5.2e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs738322 0.934 rs133019 chr22:38573035 A/G cg17652424 chr22:38574118 PLA2G6 -0.35 -6.2 -0.36 2.21e-9 Cutaneous nevi; CESC cis rs933688 0.532 rs997737 chr5:90567031 C/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.48 -5.88 -0.34 1.23e-8 Smoking behavior; CESC cis rs9322193 0.504 rs7771014 chr6:150205446 T/A cg09699651 chr6:150184138 LRP11 0.55 7.55 0.42 7.25e-13 Lung cancer; CESC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 9.9 0.52 7.53e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg18758796 chr5:131593413 PDLIM4 0.47 6.82 0.39 6.01e-11 Breast cancer; CESC cis rs10861342 1.000 rs11112396 chr12:105568359 T/G cg23923672 chr12:105501055 KIAA1033 0.62 5.38 0.31 1.66e-7 IgG glycosylation; CESC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.47 -5.62 -0.33 4.72e-8 Bipolar disorder; CESC cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg25517755 chr10:38738941 LOC399744 -0.46 -5.98 -0.34 7.23e-9 Extrinsic epigenetic age acceleration; CESC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.49 6.01 0.35 6.17e-9 Tonsillectomy; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg03358980 chr10:102770406 NA 0.54 7.23 0.41 5.05e-12 Thyroid stimulating hormone; CESC cis rs9611565 0.546 rs5758430 chr22:42109844 G/T cg06481639 chr22:41940642 POLR3H 0.64 6.55 0.37 2.94e-10 Vitiligo; CESC cis rs9640161 0.702 rs11765692 chr7:150026567 C/T cg13722127 chr7:150037890 RARRES2 0.34 5.15 0.3 5.13e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg14664628 chr15:75095509 CSK -0.56 -7.61 -0.42 4.86e-13 Breast cancer; CESC cis rs7833790 0.654 rs7835342 chr8:82698092 A/G cg02079420 chr8:82753780 SNX16 0.5 7.56 0.42 6.82e-13 Diastolic blood pressure; CESC cis rs2204008 0.782 rs117824012 chr12:38215517 T/C cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07855967 chr6:13486425 C6orf114;GFOD1 0.54 6.19 0.36 2.29e-9 Gut microbiome composition (summer); CESC cis rs1348850 0.793 rs13000048 chr2:178337089 C/A cg22681709 chr2:178499509 PDE11A -0.39 -5.77 -0.33 2.21e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.62 0.33 4.88e-8 Bipolar disorder; CESC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg12564285 chr5:131593104 PDLIM4 0.38 5.8 0.34 1.92e-8 Acylcarnitine levels; CESC trans rs17764205 0.777 rs17696630 chr19:3261995 A/G cg22881279 chr8:90996602 NBN -0.79 -6.26 -0.36 1.53e-9 Bipolar disorder and schizophrenia; CESC cis rs6951245 0.810 rs117800627 chr7:1081075 G/C cg23708337 chr7:1209742 NA 0.53 5.3 0.31 2.41e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2559856 0.904 rs2695283 chr12:102089391 G/C cg15068132 chr12:102092402 CHPT1 -0.43 -5.64 -0.33 4.26e-8 Blood protein levels; CESC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs4481887 0.676 rs6691314 chr1:248548020 G/A cg26353448 chr1:248524236 OR2T4 -0.37 -5.11 -0.3 6.17e-7 Common traits (Other); CESC cis rs2228479 0.850 rs17226666 chr16:89835401 G/A cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg25985355 chr7:65971099 NA -0.33 -5.46 -0.32 1.07e-7 Aortic root size; CESC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg06221963 chr1:154839813 KCNN3 -0.66 -11.32 -0.57 1.71e-24 Prostate cancer; CESC cis rs933688 1.000 rs1964292 chr5:90743608 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 11.04 0.56 1.47e-23 Smoking behavior; CESC cis rs11997175 0.625 rs953617 chr8:33599158 G/C ch.8.33884649F chr8:33765107 NA 0.56 7.05 0.4 1.53e-11 Body mass index; CESC cis rs1559088 1.000 rs12979164 chr19:33553228 G/C cg27124370 chr19:33622961 WDR88 0.42 5.34 0.31 1.98e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg22143856 chr6:28129313 ZNF389 0.52 6.77 0.38 8.31e-11 Depression; CESC cis rs3744061 0.569 rs2240769 chr17:74718155 C/T cg27546012 chr17:74684504 MXRA7 -0.55 -7.87 -0.44 8.79e-14 Retinal arteriolar caliber; CESC cis rs6032067 0.929 rs7344269 chr20:43828668 C/T cg10761708 chr20:43804764 PI3 -0.52 -6.3 -0.36 1.21e-9 Blood protein levels; CESC cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg03676636 chr4:99064102 C4orf37 0.34 5.21 0.3 3.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7818688 1.000 rs73276406 chr8:96021760 G/C cg16049864 chr8:95962084 TP53INP1 0.61 5.74 0.33 2.62e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26748028 chr19:40697398 MAP3K10 0.57 6.7 0.38 1.22e-10 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 8.15 0.45 1.44e-14 Bipolar disorder; CESC cis rs910316 1.000 rs13099 chr14:75599155 G/A cg11812906 chr14:75593930 NEK9 -0.87 -15.0 -0.68 3.09e-37 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07611531 chr2:54853149 SPTBN1 -0.57 -6.46 -0.37 5.07e-10 Gut microbiome composition (summer); CESC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg21951975 chr1:209979733 IRF6 0.56 7.38 0.41 2.06e-12 Cleft lip with or without cleft palate; CESC cis rs11792861 0.781 rs2151426 chr9:111743797 A/C cg05043794 chr9:111880884 C9orf5 -0.38 -6.27 -0.36 1.45e-9 Menarche (age at onset); CESC cis rs1707322 0.682 rs12037459 chr1:46094959 T/G cg03146154 chr1:46216737 IPP 0.79 11.1 0.56 8.93e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg09035930 chr12:129282057 SLC15A4 -0.69 -9.15 -0.49 1.53e-17 Systemic lupus erythematosus; CESC cis rs6740322 0.841 rs10211126 chr2:43551416 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -7.3 -0.41 3.35e-12 Coronary artery disease; CESC cis rs12530845 0.887 rs59400686 chr7:135360029 A/G cg23117316 chr7:135346802 PL-5283 -0.44 -5.2 -0.3 3.94e-7 Red blood cell traits; CESC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 13.19 0.63 7.09e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07013326 chr6:57037090 BAG2 0.6 7.43 0.42 1.5e-12 Gut microbiome composition (summer); CESC cis rs4805272 0.512 rs17772319 chr19:29343064 T/A cg12756686 chr19:29218302 NA 0.44 5.83 0.34 1.65e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs7607369 0.714 rs4674332 chr2:219604326 C/T cg02176678 chr2:219576539 TTLL4 0.49 8.72 0.47 3.03e-16 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs3820068 0.581 rs1122386 chr1:15946877 C/T cg13390004 chr1:15929781 NA 0.37 5.95 0.34 8.6e-9 Systolic blood pressure; CESC cis rs8053891 0.615 rs2000999 chr16:72108093 G/A cg16558253 chr16:72132732 DHX38 -0.53 -6.36 -0.36 8.8e-10 Coronary artery disease; CESC cis rs4450798 0.691 rs62234793 chr3:13752409 G/A cg05589046 chr3:13742034 LOC285375 0.37 5.52 0.32 8.18e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9814567 1.000 rs10935120 chr3:134233092 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.43 5.96 0.34 8.16e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg18876405 chr7:65276391 NA -0.53 -7.2 -0.4 6.41e-12 Aortic root size; CESC cis rs9287719 0.745 rs4997810 chr2:10755540 T/A cg00105475 chr2:10696890 NA 0.37 5.2 0.3 3.96e-7 Prostate cancer; CESC cis rs7267979 0.966 rs2261784 chr20:25262396 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.11e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg23978390 chr7:1156363 C7orf50 0.52 7.09 0.4 1.24e-11 Longevity;Endometriosis; CESC cis rs2832191 0.791 rs2832198 chr21:30498240 C/T cg08807101 chr21:30365312 RNF160 0.7 9.75 0.51 2.12e-19 Dental caries; CESC cis rs12960472 0.577 rs13381537 chr18:52388332 A/C cg12377874 chr18:52495404 RAB27B -0.34 -5.07 -0.3 7.46e-7 Positive affect; CESC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg11494091 chr17:61959527 GH2 0.4 5.65 0.33 4.03e-8 Height; CESC cis rs1545257 0.505 rs12988810 chr2:24635093 G/T cg06627628 chr2:24431161 ITSN2 -0.47 -5.73 -0.33 2.72e-8 Sjögren's syndrome; CESC cis rs1005277 0.579 rs1780130 chr10:38485378 T/A cg25517755 chr10:38738941 LOC399744 -0.49 -6.36 -0.36 9e-10 Extrinsic epigenetic age acceleration; CESC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg18876405 chr7:65276391 NA -0.57 -7.55 -0.42 6.82e-13 Aortic root size; CESC cis rs2235649 0.798 rs9932875 chr16:1848012 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -5.3 -0.31 2.43e-7 Blood metabolite levels; CESC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg18252515 chr7:66147081 NA -0.47 -6.08 -0.35 4.25e-9 Aortic root size; CESC cis rs7191700 0.511 rs12923756 chr16:11359675 C/T cg00044050 chr16:11439710 C16orf75 -0.43 -5.22 -0.31 3.67e-7 Multiple sclerosis; CESC cis rs40363 0.720 rs4453493 chr16:3533881 T/C cg00484396 chr16:3507460 NAT15 -0.5 -7.81 -0.43 1.35e-13 Tuberculosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13775054 chr21:47648555 LSS;MCM3APAS -0.44 -6.18 -0.35 2.46e-9 Fibrinogen levels; CESC trans rs9354308 1.000 rs9342503 chr6:66565436 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.54 -6.56 -0.37 2.89e-10 Metabolite levels; CESC cis rs611744 0.604 rs6469170 chr8:109305277 T/C cg21045802 chr8:109455806 TTC35 0.57 7.08 0.4 1.33e-11 Dupuytren's disease; CESC cis rs9486719 0.947 rs12210834 chr6:96890407 A/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.72 0.38 1.12e-10 Bipolar disorder; CESC cis rs4319547 0.656 rs9788145 chr12:122899522 C/T cg05707623 chr12:122985044 ZCCHC8 -0.52 -5.9 -0.34 1.12e-8 Body mass index; CESC cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg13877915 chr19:58951672 ZNF132 0.39 5.82 0.34 1.7e-8 Uric acid clearance; CESC cis rs72634258 0.554 rs12061787 chr1:7888730 G/C cg26816564 chr1:7831052 VAMP3 0.58 5.19 0.3 4.19e-7 Inflammatory bowel disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00491963 chr11:57335356 UBE2L6 -0.52 -7.05 -0.4 1.58e-11 Ulcerative colitis; CESC cis rs921968 0.565 rs6436071 chr2:219598041 A/T cg02176678 chr2:219576539 TTLL4 -0.45 -8.06 -0.44 2.61e-14 Mean corpuscular hemoglobin concentration; CESC cis rs6545883 0.965 rs7591345 chr2:61729641 T/A cg15711740 chr2:61764176 XPO1 -0.41 -5.12 -0.3 5.86e-7 Tuberculosis; CESC cis rs1499614 1.000 rs1267817 chr7:66110040 G/T cg12463550 chr7:65579703 CRCP 0.75 5.85 0.34 1.42e-8 Gout; CESC cis rs9649465 1.000 rs13224762 chr7:123370710 A/G cg04330084 chr7:123175371 IQUB -0.38 -5.18 -0.3 4.46e-7 Migraine; CESC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg11764359 chr7:65958608 NA -0.7 -9.03 -0.48 3.71e-17 Aortic root size; CESC cis rs2836974 0.931 rs2989330 chr21:40716209 A/G cg11890956 chr21:40555474 PSMG1 0.98 13.12 0.63 1.2e-30 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02496295 chr4:2846155 ADD1 0.57 6.52 0.37 3.64e-10 Gut microbiome composition (summer); CESC cis rs654950 0.776 rs2759252 chr1:42021854 G/A cg06885757 chr1:42089581 HIVEP3 -0.63 -9.83 -0.52 1.23e-19 Airway imaging phenotypes; CESC cis rs9611565 0.918 rs12484074 chr22:41752747 G/A cg17376030 chr22:41985996 PMM1 0.63 6.54 0.37 3.06e-10 Vitiligo; CESC cis rs559928 0.557 rs7122408 chr11:63898826 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 5.74 0.33 2.56e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC trans rs2272205 0.808 rs62226770 chr2:227954056 T/A cg04768315 chr2:1898518 MYT1L 0.73 6.05 0.35 4.9e-9 Immune reponse to smallpox (secreted IFN-alpha); CESC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg21984481 chr17:79567631 NPLOC4 -0.34 -5.34 -0.31 2.04e-7 Eye color traits; CESC cis rs6460942 1.000 rs6460936 chr7:12404913 T/C cg10578991 chr7:12443926 VWDE -0.55 -5.86 -0.34 1.36e-8 Coronary artery disease; CESC cis rs7202877 0.706 rs467780 chr16:75437138 A/G cg04384234 chr16:75411784 CFDP1 0.49 5.74 0.33 2.54e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs2072732 0.904 rs1138513 chr1:2976816 T/C cg15211996 chr1:2936768 ACTRT2 0.35 6.02 0.35 5.73e-9 Plateletcrit; CESC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs9486719 0.741 rs2049927 chr6:96848958 C/G cg06623918 chr6:96969491 KIAA0776 -0.65 -6.24 -0.36 1.73e-9 Migraine;Coronary artery disease; CESC cis rs11958404 0.615 rs7737601 chr5:157448269 C/T cg05962755 chr5:157440814 NA -0.36 -5.31 -0.31 2.34e-7 IgG glycosylation; CESC cis rs1707322 1.000 rs12403666 chr1:46431621 G/A cg03146154 chr1:46216737 IPP 0.75 10.29 0.53 4.13e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg16680214 chr1:154839983 KCNN3 -0.44 -6.52 -0.37 3.58e-10 Prostate cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00531924 chr6:111279890 GTF3C6 -0.51 -6.73 -0.38 1.06e-10 Ulcerative colitis; CESC cis rs4835473 0.715 rs4538428 chr4:144913904 A/G cg25736465 chr4:144833511 NA 0.43 6.44 0.37 5.61e-10 Immature fraction of reticulocytes; CESC cis rs2228479 0.717 rs62052210 chr16:89980158 A/G cg06558623 chr16:89946397 TCF25 0.9 7.96 0.44 5.2e-14 Skin colour saturation; CESC trans rs11098499 0.909 rs9994810 chr4:120381590 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.91 0.52 6.89e-20 Corneal astigmatism; CESC cis rs35272691 1 rs35272691 chr17:38157841 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.61 9.08 0.49 2.6e-17 White blood cell count (neutrophil); CESC cis rs7246657 0.941 rs7256130 chr19:37933981 T/C cg23950597 chr19:37808831 NA -0.54 -6.03 -0.35 5.49e-9 Coronary artery calcification; CESC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.51 -6.95 -0.39 2.83e-11 Menarche (age at onset); CESC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg18252515 chr7:66147081 NA -0.43 -5.6 -0.33 5.39e-8 Aortic root size; CESC cis rs11098499 0.863 rs3775849 chr4:120450908 G/C cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.24e-28 Corneal astigmatism; CESC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg23172400 chr8:95962367 TP53INP1 0.41 8.25 0.45 7.29e-15 Type 2 diabetes; CESC cis rs7666738 0.830 rs35752787 chr4:98935202 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9902453 0.817 rs3115089 chr17:28031881 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 9.06 0.49 2.98e-17 Coffee consumption (cups per day); CESC cis rs7202877 0.561 rs9933956 chr16:75362813 T/C cg04384234 chr16:75411784 CFDP1 -0.49 -5.84 -0.34 1.51e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs1801251 1.000 rs6746294 chr2:233583050 C/G cg25237894 chr2:233734115 C2orf82 -0.52 -8.79 -0.48 1.92e-16 Coronary artery disease; CESC cis rs3106136 0.609 rs10433970 chr4:95134165 C/G cg11021082 chr4:95130006 SMARCAD1 -0.47 -6.43 -0.37 5.89e-10 Capecitabine sensitivity; CESC cis rs2115536 0.606 rs8024713 chr15:80206958 C/G cg00225070 chr15:80189496 MTHFS 0.56 7.0 0.4 2.07e-11 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00474734 chr12:53645975 MFSD5 0.6 6.82 0.39 6.14e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs60007031 chr4:98824753 G/C cg17366294 chr4:99064904 C4orf37 0.55 7.54 0.42 7.48e-13 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.644 rs72783627 chr2:24315685 A/C cg08917208 chr2:24149416 ATAD2B 0.55 5.3 0.31 2.47e-7 Lymphocyte counts; CESC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg22920501 chr2:26401640 FAM59B -0.67 -8.09 -0.44 2.22e-14 Gut microbiome composition (summer); CESC cis rs9303401 0.659 rs34468504 chr17:56648277 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.56e-29 Cognitive test performance; CESC cis rs6444746 1.000 rs1797849 chr3:193511570 C/T cg22553634 chr3:193489233 NA -0.41 -5.06 -0.3 7.9e-7 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); CESC cis rs6121246 0.523 rs6060286 chr20:30197663 C/A cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs3747547 0.892 rs72724200 chr9:37952144 G/A cg13774184 chr9:37916125 SHB -0.72 -6.15 -0.35 2.81e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs1814175 0.676 rs1851859 chr11:49860405 A/T cg15704280 chr7:45808275 SEPT13 -1.0 -18.48 -0.75 1.42e-49 Height; CESC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.07e-8 Lung cancer; CESC trans rs9296661 0.522 rs6458776 chr6:51646459 C/T cg15101985 chr10:85961501 PCDH21 -0.46 -6.03 -0.35 5.35e-9 Weight loss (gastric bypass surgery); CESC cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg07697082 chr8:82753677 SNX16 -0.37 -5.73 -0.33 2.67e-8 Diastolic blood pressure; CESC cis rs9815354 1.000 rs9847975 chr3:41786904 A/G cg03022575 chr3:42003672 ULK4 0.58 5.63 0.33 4.49e-8 Pulse pressure;Diastolic blood pressure; CESC trans rs4843747 0.709 rs72818521 chr16:88058751 C/G cg26811252 chr16:29126840 RRN3P2 0.74 9.8 0.52 1.53e-19 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12713142 chr12:57081325 PTGES3 0.47 6.41 0.37 6.58e-10 Gut microbiota (bacterial taxa); CESC cis rs2439831 0.850 rs558656 chr15:43723514 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.79 11.53 0.58 3.33e-25 Lung cancer in ever smokers; CESC cis rs4523957 0.583 rs2957926 chr17:2024030 C/T cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9443189 0.570 rs567903 chr6:76327851 C/T cg01950844 chr6:76311363 SENP6 0.9 9.72 0.51 2.65e-19 Prostate cancer; CESC cis rs16937 0.711 rs6675633 chr1:205100480 G/A cg00857998 chr1:205179979 DSTYK 0.39 5.2 0.3 4.05e-7 Schizophrenia; CESC cis rs9309473 0.519 rs7598901 chr2:73675844 C/T cg20560298 chr2:73613845 ALMS1 0.49 7.03 0.4 1.74e-11 Metabolite levels; CESC cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg04455712 chr21:45112962 RRP1B 0.39 5.85 0.34 1.46e-8 Mean corpuscular volume; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05421555 chr15:85924342 AKAP13 0.47 6.3 0.36 1.25e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs986417 1.000 rs1956554 chr14:60963775 C/T cg00859478 chr14:60978094 SIX6 -0.45 -5.11 -0.3 6.2e-7 Gut microbiota (bacterial taxa); CESC cis rs2274273 0.615 rs67008693 chr14:55702693 T/C cg04306507 chr14:55594613 LGALS3 0.31 5.2 0.3 3.97e-7 Protein biomarker; CESC cis rs6964587 1.000 rs1859113 chr7:91679887 T/C cg17063962 chr7:91808500 NA 0.59 8.15 0.45 1.48e-14 Breast cancer; CESC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg18446336 chr7:2847575 GNA12 -0.38 -5.62 -0.33 4.89e-8 Height; CESC cis rs2228479 0.850 rs62052714 chr16:89857180 T/C cg19635926 chr16:89946313 TCF25 0.67 5.08 0.3 7.19e-7 Skin colour saturation; CESC cis rs1843834 0.858 rs2047136 chr2:225511361 A/T cg22455342 chr2:225449267 CUL3 0.5 6.5 0.37 3.98e-10 IgE levels in asthmatics (D.p. specific); CESC cis rs8078723 0.866 rs7502514 chr17:38188844 A/G cg17467752 chr17:38218738 THRA -0.69 -10.97 -0.56 2.57e-23 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs7937682 1.000 rs9734135 chr11:111536190 G/A cg09085632 chr11:111637200 PPP2R1B -0.96 -15.3 -0.68 2.74e-38 Primary sclerosing cholangitis; CESC cis rs7107174 1.000 rs10793302 chr11:78040961 C/T cg02023728 chr11:77925099 USP35 0.4 5.69 0.33 3.36e-8 Testicular germ cell tumor; CESC cis rs7582720 1.000 rs115396314 chr2:203721314 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs13191362 1.000 rs35754151 chr6:163074867 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.93 8.48 0.46 1.56e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3820928 0.874 rs4144328 chr2:227790187 A/C cg05526886 chr2:227700861 RHBDD1 -0.39 -5.07 -0.3 7.53e-7 Pulmonary function; CESC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg14558114 chr2:88469736 THNSL2 -0.5 -7.28 -0.41 3.87e-12 Response to metformin (IC50); CESC cis rs7666738 0.606 rs4637413 chr4:99088151 A/G cg05340658 chr4:99064831 C4orf37 0.65 9.03 0.49 3.66e-17 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.05e-8 Lung cancer; CESC trans rs11770686 0.967 rs4728289 chr7:75348505 C/T cg06613775 chr12:88897441 KITLG -0.36 -6.05 -0.35 4.84e-9 Essential tremor; CESC cis rs17376456 1.000 rs13185608 chr5:93509688 T/G cg21475434 chr5:93447410 FAM172A 0.9 7.77 0.43 1.68e-13 Diabetic retinopathy; CESC cis rs17253792 0.822 rs79873916 chr14:56172631 G/C cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg07507251 chr3:52567010 NT5DC2 0.41 7.02 0.4 1.85e-11 Bipolar disorder; CESC cis rs7772486 0.806 rs2253648 chr6:146199296 G/A cg23711669 chr6:146136114 FBXO30 0.83 12.3 0.6 8.35e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs3740713 1.000 rs73440634 chr11:18473546 T/A cg23797887 chr11:18477753 LDHAL6A -0.57 -5.81 -0.34 1.8e-8 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg04414720 chr1:150670196 GOLPH3L 0.63 9.03 0.48 3.76e-17 Tonsillectomy; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg06193169 chr4:58030481 NA 0.41 6.01 0.35 6.13e-9 Retinol levels; CESC cis rs10911363 0.592 rs2782411 chr1:183476929 G/A cg09173681 chr1:183549694 NCF2 0.51 7.5 0.42 9.45e-13 Systemic lupus erythematosus; CESC cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg01579765 chr21:45077557 HSF2BP -0.54 -9.11 -0.49 2.15e-17 Mean corpuscular volume; CESC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg25072359 chr17:41440525 NA 0.48 6.52 0.37 3.45e-10 Menopause (age at onset); CESC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg26039829 chr8:22132926 PIWIL2 0.37 5.63 0.33 4.57e-8 Hypertriglyceridemia; CESC cis rs7116495 0.609 rs567026 chr11:71769952 C/T cg10381502 chr11:71823885 C11orf51 1.1 7.06 0.4 1.43e-11 Severe influenza A (H1N1) infection; CESC cis rs4566357 1.000 rs4536647 chr2:227921977 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -5.27 -0.31 2.77e-7 Coronary artery disease; CESC cis rs7546094 1.000 rs7554916 chr1:113123734 A/C cg22162597 chr1:113214053 CAPZA1 0.37 5.67 0.33 3.64e-8 Platelet distribution width; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg15825501 chr1:936610 HES4 0.51 6.48 0.37 4.48e-10 Thyroid stimulating hormone; CESC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg07157834 chr1:205819609 PM20D1 0.38 5.4 0.31 1.46e-7 Prostate cancer; CESC cis rs12762955 0.507 rs7070724 chr10:1040138 C/T cg18964960 chr10:1102726 WDR37 -0.43 -5.31 -0.31 2.28e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs6598955 0.724 rs10902731 chr1:26600793 A/G cg04990556 chr1:26633338 UBXN11 -0.75 -10.67 -0.55 2.45e-22 Obesity-related traits; CESC cis rs4835473 0.932 rs4835034 chr4:144742691 T/C cg25736465 chr4:144833511 NA -0.32 -5.07 -0.3 7.42e-7 Immature fraction of reticulocytes; CESC cis rs9911578 0.933 rs2531726 chr17:56522533 C/T cg05425664 chr17:57184151 TRIM37 0.46 6.47 0.37 4.75e-10 Intelligence (multi-trait analysis); CESC cis rs889398 0.771 rs3790080 chr16:69902139 A/G cg09409435 chr16:70099608 PDXDC2 0.39 5.03 0.3 9.19e-7 Body mass index; CESC cis rs7998202 0.567 rs7982570 chr13:113370892 T/C cg02820901 chr13:113351484 ATP11A 0.66 5.41 0.32 1.39e-7 Glycated hemoglobin levels; CESC cis rs6582630 0.502 rs11181475 chr12:38348922 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.77 0.33 2.24e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs7223966 0.961 rs17631783 chr17:61687600 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.47 -5.26 -0.31 3e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs10979 1.000 rs1416205 chr6:143889397 T/C cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs4243830 1.000 rs58415361 chr1:6592377 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.76 6.06 0.35 4.57e-9 Body mass index; CESC trans rs875971 0.838 rs2173570 chr7:65762963 T/A cg26939375 chr7:64535504 NA -0.46 -6.12 -0.35 3.39e-9 Aortic root size; CESC cis rs1670533 1.000 rs6812586 chr4:1069851 A/G cg27284194 chr4:1044797 NA 0.45 5.73 0.33 2.78e-8 Recombination rate (females); CESC trans rs877282 0.755 rs1769242 chr10:787896 T/C cg22713356 chr15:30763199 NA 1.1 11.9 0.59 1.95e-26 Uric acid levels; CESC trans rs1814175 0.588 rs1721994 chr11:49914050 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs1707322 0.721 rs12091503 chr1:46107868 T/C cg03146154 chr1:46216737 IPP 0.82 11.48 0.58 4.81e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6547741 1.000 rs10205364 chr2:27794233 C/T cg27432699 chr2:27873401 GPN1 0.5 7.01 0.4 2.01e-11 Oral cavity cancer; CESC cis rs2361718 0.933 rs8066452 chr17:78104080 A/G cg06718696 chr17:78121285 EIF4A3 0.46 6.14 0.35 2.98e-9 Yeast infection; CESC cis rs3820068 0.580 rs12747696 chr1:16002978 A/G cg17385448 chr1:15911702 AGMAT 0.4 6.13 0.35 3.14e-9 Systolic blood pressure; CESC cis rs754466 0.580 rs2579177 chr10:79529245 C/T cg17075019 chr10:79541650 NA -0.82 -12.28 -0.6 9.46e-28 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9527 0.545 rs11191602 chr10:104954219 C/T cg04362960 chr10:104952993 NT5C2 0.45 5.71 0.33 2.98e-8 Arsenic metabolism; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg23104823 chr14:45553408 PRPF39 0.47 6.54 0.37 3.16e-10 Weight; CESC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg02038168 chr22:39784481 NA -0.61 -7.35 -0.41 2.48e-12 Intelligence (multi-trait analysis); CESC cis rs9291683 0.507 rs3775940 chr4:10025163 A/T cg02734326 chr4:10020555 SLC2A9 0.4 5.62 0.33 4.89e-8 Bone mineral density; CESC cis rs7762018 1.000 rs7762018 chr6:170113244 G/T cg05834625 chr6:170176447 C6orf70 0.55 6.53 0.37 3.38e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg19592336 chr6:28129416 ZNF389 0.6 8.08 0.44 2.36e-14 Parkinson's disease; CESC cis rs9611565 0.649 rs9623450 chr22:42175231 G/A cg06481639 chr22:41940642 POLR3H 0.47 5.28 0.31 2.67e-7 Vitiligo; CESC cis rs8062405 1.000 rs62037369 chr16:28883841 C/T cg05966235 chr16:28915196 ATP2A1 0.34 5.03 0.3 9.05e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs708547 1.000 rs2412770 chr4:57794660 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -5.44 -0.32 1.23e-7 Response to bleomycin (chromatid breaks); CESC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg02569458 chr12:86230093 RASSF9 0.54 8.12 0.45 1.72e-14 Major depressive disorder; CESC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg18876405 chr7:65276391 NA -0.67 -9.44 -0.5 1.99e-18 Aortic root size; CESC cis rs1775715 0.675 rs2808085 chr10:32148599 C/T cg18675610 chr10:32216311 ARHGAP12 0.35 5.48 0.32 1.01e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs12136530 0.774 rs4912094 chr1:19762466 A/G cg01832549 chr1:19774989 CAPZB 0.46 6.48 0.37 4.46e-10 Lead levels in blood; CESC cis rs6088590 1.000 rs6119524 chr20:33373813 C/T cg24642439 chr20:33292090 TP53INP2 0.84 11.75 0.59 6.33e-26 Coronary artery disease; CESC cis rs644799 0.625 rs1255175 chr11:95471186 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.5 6.94 0.39 2.96e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs637571 0.584 rs594689 chr11:65635559 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.68 -8.47 -0.46 1.66e-15 Eosinophil percentage of white cells; CESC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.53 -0.32 7.81e-8 Huntington's disease progression; CESC cis rs9611565 0.525 rs9611549 chr22:41705909 C/G cg06481639 chr22:41940642 POLR3H -0.52 -5.74 -0.33 2.57e-8 Vitiligo; CESC cis rs6088590 1.000 rs1998028 chr20:33344595 A/T cg08999081 chr20:33150536 PIGU 0.59 8.89 0.48 9.62e-17 Coronary artery disease; CESC cis rs80033912 0.640 rs6785832 chr3:49224316 C/T cg07636037 chr3:49044803 WDR6 0.48 5.8 0.34 1.89e-8 Intelligence (multi-trait analysis); CESC trans rs10254160 1.000 rs2396535 chr7:112055321 A/T cg27408540 chr10:25465171 LOC100128811;GPR158 -0.64 -6.29 -0.36 1.3e-9 Parental extreme longevity (95 years and older); CESC cis rs6493487 0.512 rs71471584 chr15:51261229 T/A cg02338191 chr15:51200825 AP4E1 0.61 5.58 0.32 6.04e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg03188948 chr7:1209495 NA 0.7 6.62 0.38 2.02e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg19468946 chr17:37922297 IKZF3 -0.39 -5.05 -0.3 8.23e-7 Glomerular filtration rate (creatinine); CESC cis rs6942756 1.000 rs56026912 chr7:128913937 A/G cg02491457 chr7:128862824 NA -0.69 -9.65 -0.51 4.48e-19 White matter hyperintensity burden; CESC cis rs7223966 1.000 rs992416 chr17:61745905 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.44 0.37 5.7e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs116095464 0.558 rs6555058 chr5:226376 C/T cg12570787 chr5:219185 SDHA;CCDC127 -0.51 -5.42 -0.32 1.37e-7 Breast cancer; CESC cis rs17253792 0.749 rs17747301 chr14:56125030 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.83 5.86 0.34 1.35e-8 Putamen volume; CESC trans rs7824557 0.564 rs4631424 chr8:11236809 T/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.15 -0.35 2.9e-9 Retinal vascular caliber; CESC trans rs208520 0.690 rs207119 chr6:66786408 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.83 -0.62 1.2e-29 Exhaled nitric oxide output; CESC cis rs561341 0.883 rs7406056 chr17:30220224 C/T cg12193833 chr17:30244370 NA -0.58 -6.06 -0.35 4.77e-9 Hip circumference adjusted for BMI; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12581730 chr6:170599861 DLL1 -0.5 -6.95 -0.39 2.85e-11 Gut microbiota (bacterial taxa); CESC cis rs5753618 0.583 rs5749270 chr22:31812853 C/T cg13145458 chr22:31556086 RNF185 -0.5 -5.96 -0.34 7.96e-9 Colorectal cancer; CESC cis rs13191362 0.507 rs2023036 chr6:163122736 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.56 6.72 0.38 1.09e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6547741 1.000 rs6750943 chr2:27777904 T/G cg21248554 chr2:27665150 KRTCAP3 0.24 5.06 0.3 7.83e-7 Oral cavity cancer; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg18591801 chr3:52553433 STAB1 -0.3 -5.69 -0.33 3.39e-8 Electroencephalogram traits; CESC cis rs5769765 1.000 rs910800 chr22:50278642 C/T cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs1372520 0.684 rs2197120 chr4:90729602 A/G cg15133208 chr4:90757351 SNCA -0.43 -5.79 -0.33 2.02e-8 Neuroticism; CESC cis rs73206853 0.609 rs12311902 chr12:110883799 T/C cg12870014 chr12:110450643 ANKRD13A 0.62 5.43 0.32 1.25e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs950776 0.518 rs2869055 chr15:78822388 G/C cg06917634 chr15:78832804 PSMA4 -0.7 -10.61 -0.55 3.8e-22 Sudden cardiac arrest; CESC cis rs17826219 0.706 rs8075357 chr17:29057197 A/C cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Body mass index; CESC trans rs9467711 0.606 rs67509210 chr6:26354100 G/T cg06606381 chr12:133084897 FBRSL1 -0.77 -7.0 -0.4 2.04e-11 Autism spectrum disorder or schizophrenia; CESC cis rs3820068 0.705 rs11587541 chr1:15899478 T/C cg18192808 chr1:15853278 DNAJC16 0.43 5.13 0.3 5.68e-7 Systolic blood pressure; CESC cis rs7917772 0.536 rs4919667 chr10:104426011 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.55 -7.12 -0.4 1e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg05564831 chr3:52568323 NT5DC2 0.45 6.91 0.39 3.55e-11 Bipolar disorder; CESC cis rs4727027 0.933 rs2158633 chr7:148832652 C/T cg23583168 chr7:148888333 NA -0.78 -12.15 -0.6 2.62e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg22433210 chr17:43662623 NA 0.63 7.4 0.41 1.85e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6912958 0.754 rs1051131 chr6:88221546 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.11 -0.3 6.11e-7 Monocyte percentage of white cells; CESC trans rs11098499 0.863 rs7657849 chr4:120455494 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.47e-19 Corneal astigmatism; CESC cis rs9287719 0.967 rs759402 chr2:10729554 A/T cg02196655 chr2:10830764 NOL10 -0.36 -5.57 -0.32 6.1e-8 Prostate cancer; CESC cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg21138405 chr5:131827807 IRF1 -0.58 -10.06 -0.53 2.22e-20 Asthma (sex interaction); CESC cis rs4450798 0.793 rs4640541 chr3:13758997 C/G cg23332027 chr3:13681764 NA -0.38 -5.3 -0.31 2.38e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs116095464 0.558 rs10065239 chr5:275288 C/T cg22857025 chr5:266934 NA -1.3 -13.99 -0.65 1.1e-33 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24686684 chr20:48330546 B4GALT5 0.68 8.3 0.45 5.45e-15 Gut microbiome composition (summer); CESC cis rs7267979 1.000 rs2856 chr20:25433536 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.96 0.74 1e-47 Liver enzyme levels (alkaline phosphatase); CESC cis rs2288073 0.801 rs6757275 chr2:24375230 A/G cg20701182 chr2:24300061 SF3B14 0.45 5.6 0.33 5.39e-8 Venous thromboembolism (SNP x SNP interaction); CESC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg00149659 chr3:10157352 C3orf10 0.7 8.31 0.45 5.08e-15 Alzheimer's disease; CESC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg23281280 chr6:28129359 ZNF389 -0.56 -7.45 -0.42 1.3e-12 Depression; CESC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg23803603 chr1:2058230 PRKCZ -0.35 -5.8 -0.34 1.91e-8 Height; CESC cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg06022373 chr22:39101656 GTPBP1 0.89 14.42 0.66 3.47e-35 Menopause (age at onset); CESC cis rs2380220 0.574 rs7766765 chr6:95997362 G/A cg23517279 chr6:96025343 MANEA 0.54 5.8 0.34 1.85e-8 Behavioural disinhibition (generation interaction); CESC cis rs11122272 0.735 rs722302 chr1:231480152 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.23 -0.41 5.18e-12 Hemoglobin concentration; CESC cis rs6032067 0.929 rs6032049 chr20:43825556 C/T cg11264863 chr20:43835661 SEMG1 0.49 5.29 0.31 2.5e-7 Blood protein levels; CESC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg10691866 chr7:65817282 TPST1 -0.35 -5.95 -0.34 8.45e-9 Aortic root size; CESC cis rs9314323 0.524 rs7816609 chr8:26202482 A/C cg11498726 chr8:26250323 BNIP3L -0.39 -5.45 -0.32 1.16e-7 Red cell distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22239605 chr11:237153 PSMD13;SIRT3 0.53 6.36 0.36 8.7e-10 Gut microbiome composition (summer); CESC cis rs941873 0.900 rs4979861 chr10:81131595 A/G cg08514558 chr10:81106712 PPIF 0.39 6.73 0.38 1.05e-10 Height; CESC cis rs9291683 0.595 rs11722930 chr4:10035454 G/A cg02734326 chr4:10020555 SLC2A9 0.49 6.87 0.39 4.48e-11 Bone mineral density; CESC trans rs12681287 0.547 rs6998303 chr8:87510185 T/C cg27317242 chr8:23145699 R3HCC1 -0.53 -6.34 -0.36 9.67e-10 Caudate activity during reward; CESC cis rs116095464 1.000 rs3777237 chr5:307641 C/T cg22496380 chr5:211416 CCDC127 -0.9 -5.5 -0.32 9.1e-8 Breast cancer; CESC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg08968635 chr6:28129556 ZNF389 0.38 5.11 0.3 6.32e-7 Depression; CESC cis rs79349575 0.783 rs4294857 chr17:46983391 G/A cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs1401999 0.714 rs1000002 chr3:183635768 A/G cg01324343 chr3:183735012 ABCC5 -0.46 -8.85 -0.48 1.26e-16 Anterior chamber depth; CESC cis rs4148883 0.675 rs28762430 chr4:100119257 C/A cg12011299 chr4:100065546 ADH4 0.66 9.76 0.51 2.03e-19 Alcohol dependence; CESC cis rs12479064 0.724 rs11885942 chr2:100004165 A/G cg09787394 chr2:99771194 LIPT1;TSGA10 0.49 5.13 0.3 5.48e-7 Chronic sinus infection; CESC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.84 0.55 6.79e-23 Alzheimer's disease; CESC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg17971929 chr21:40555470 PSMG1 -0.6 -8.02 -0.44 3.31e-14 Menarche (age at onset); CESC cis rs1153858 1.000 rs12437840 chr15:45669055 C/A cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs4319547 0.698 rs4039670 chr12:122822655 A/G cg05707623 chr12:122985044 ZCCHC8 -0.49 -5.77 -0.33 2.24e-8 Body mass index; CESC cis rs10492096 0.947 rs10774435 chr12:6616120 G/T cg13857086 chr12:6580257 VAMP1 0.55 5.88 0.34 1.23e-8 Hip geometry; CESC cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg18131467 chr2:239335373 ASB1 0.94 14.13 0.66 3.57e-34 Multiple system atrophy; CESC cis rs7537660 1.000 rs10888255 chr1:248004687 C/G cg12080717 chr1:248004886 OR11L1 0.44 5.39 0.31 1.58e-7 Platelet distribution width; CESC cis rs7116495 0.609 rs4387373 chr11:71774908 A/G cg10381502 chr11:71823885 C11orf51 -1.14 -7.14 -0.4 8.75e-12 Severe influenza A (H1N1) infection; CESC cis rs11785400 0.793 rs34875149 chr8:143736131 G/A cg10596483 chr8:143751796 JRK 0.42 5.26 0.31 3e-7 Schizophrenia; CESC cis rs7829975 0.511 rs1401390 chr8:8136410 C/T cg06636001 chr8:8085503 FLJ10661 0.61 7.61 0.42 4.92e-13 Mood instability; CESC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg03351412 chr1:154909251 PMVK 0.68 9.0 0.48 4.57e-17 Prostate cancer; CESC cis rs7267979 1.000 rs2258563 chr20:25273435 C/T cg08601574 chr20:25228251 PYGB 0.38 5.57 0.32 6.36e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs929354 0.742 rs10274687 chr7:156933181 T/G cg05182265 chr7:156933206 UBE3C -0.49 -7.04 -0.4 1.69e-11 Body mass index; CESC cis rs1348850 0.598 rs12616259 chr2:178503803 C/T cg22681709 chr2:178499509 PDE11A -0.56 -8.81 -0.48 1.64e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4843747 0.671 rs4075998 chr16:88106776 G/A cg06374794 chr16:88002281 BANP 0.39 5.16 0.3 4.78e-7 Menopause (age at onset); CESC cis rs7236492 0.872 rs78226032 chr18:77230822 G/A cg15644404 chr18:77186268 NFATC1 -0.73 -5.57 -0.32 6.11e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs4836694 0.574 rs3824542 chr9:132936132 C/T cg13414629 chr9:132935646 FREQ 0.47 5.62 0.33 4.93e-8 Alzheimer's disease (cognitive decline); CESC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.04 0.4 1.62e-11 Bipolar disorder; CESC cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg26116260 chr4:7069785 GRPEL1 0.99 14.18 0.66 2.35e-34 Monocyte percentage of white cells; CESC cis rs6740322 0.857 rs11690012 chr2:43542480 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -6.93 -0.39 3.18e-11 Coronary artery disease; CESC cis rs4722166 0.630 rs7808457 chr7:22798265 A/T cg05265849 chr7:22767390 IL6 -0.46 -5.3 -0.31 2.45e-7 Lung cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04225510 chr10:12237758 CDC123;NUDT5 0.46 6.2 0.36 2.12e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4594175 0.962 rs72688734 chr14:51634618 T/C cg23942311 chr14:51606299 NA 0.35 5.34 0.31 2.02e-7 Cancer; CESC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.41e-28 Prudent dietary pattern; CESC cis rs2502731 1.000 rs2502731 chr9:130976557 A/G cg09976142 chr9:130955436 CIZ1 -0.53 -9.51 -0.5 1.23e-18 Attention deficit hyperactivity disorder; CESC cis rs8060686 0.920 rs73594581 chr16:67955554 G/A cg26727032 chr16:67993705 SLC12A4 -0.58 -6.75 -0.38 9.09e-11 HDL cholesterol;Metabolic syndrome; CESC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.71 -8.9 -0.48 8.99e-17 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg11494091 chr17:61959527 GH2 0.75 13.5 0.64 5.7e-32 Prudent dietary pattern; CESC cis rs7107174 1.000 rs2511175 chr11:77975081 A/G cg02023728 chr11:77925099 USP35 0.5 6.66 0.38 1.61e-10 Testicular germ cell tumor; CESC trans rs801193 0.773 rs801207 chr7:66020590 T/C cg26939375 chr7:64535504 NA -0.53 -7.31 -0.41 3.22e-12 Aortic root size; CESC cis rs7267979 1.000 rs6050609 chr20:25411751 A/G cg08601574 chr20:25228251 PYGB -0.38 -5.64 -0.33 4.38e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs36051895 0.623 rs17426903 chr9:5203292 A/C cg02405213 chr9:5042618 JAK2 -0.48 -5.39 -0.31 1.55e-7 Pediatric autoimmune diseases; CESC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg20151795 chr6:28129481 ZNF389 0.45 5.87 0.34 1.29e-8 Parkinson's disease; CESC trans rs765547 1.000 rs1822200 chr8:19852829 G/T cg12649343 chr22:47023005 GRAMD4 -0.3 -6.12 -0.35 3.27e-9 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg03452623 chr4:187889614 NA -0.88 -16.16 -0.7 2.39e-41 Lobe attachment (rater-scored or self-reported); CESC cis rs2797160 1.000 rs2747714 chr6:126007620 A/G cg05901451 chr6:126070800 HEY2 0.45 6.53 0.37 3.43e-10 Endometrial cancer; CESC cis rs9815354 1.000 rs1717020 chr3:41981490 A/C cg03022575 chr3:42003672 ULK4 0.48 5.53 0.32 7.85e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs7178572 0.568 rs62008452 chr15:77591007 A/G cg22256960 chr15:77711686 NA -0.53 -6.6 -0.38 2.26e-10 Type 2 diabetes; CESC cis rs3540 0.533 rs11633692 chr15:91056043 G/A cg22089800 chr15:90895588 ZNF774 -0.61 -8.11 -0.45 1.93e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg20887711 chr4:1340912 KIAA1530 -0.63 -8.5 -0.46 1.36e-15 Obesity-related traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg14136810 chr15:40213326 GPR176 -0.44 -6.43 -0.37 6.05e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs68170813 0.559 rs17427849 chr7:106864237 A/G cg02696742 chr7:106810147 HBP1 -0.54 -5.33 -0.31 2.13e-7 Coronary artery disease; CESC cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg20307385 chr11:47447363 PSMC3 -0.63 -7.61 -0.42 4.79e-13 Subjective well-being; CESC cis rs6831352 0.819 rs2851274 chr4:100025866 G/C cg13256891 chr4:100009986 ADH5 0.68 8.19 0.45 1.11e-14 Alcohol dependence; CESC cis rs933688 1.000 rs6452953 chr5:90723034 T/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 11.8 0.59 4.22e-26 Smoking behavior; CESC cis rs1538970 0.924 rs6657284 chr1:45879088 T/C cg24296786 chr1:45957014 TESK2 -0.45 -5.22 -0.31 3.64e-7 Platelet count; CESC cis rs2742234 0.541 rs11238490 chr10:43747598 G/A cg15436174 chr10:43711423 RASGEF1A 0.47 5.47 0.32 1.07e-7 Hirschsprung disease; CESC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 5.8 0.34 1.87e-8 Bipolar disorder; CESC cis rs765787 0.530 rs13329228 chr15:45533017 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -6.74 -0.38 9.58e-11 Uric acid levels; CESC cis rs8077889 0.750 rs231541 chr17:41941788 C/G cg26893861 chr17:41843967 DUSP3 -0.78 -7.56 -0.42 6.73e-13 Triglycerides; CESC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg08470875 chr2:26401718 FAM59B -0.77 -8.41 -0.46 2.62e-15 Gut microbiome composition (summer); CESC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg21770322 chr7:97807741 LMTK2 0.58 8.76 0.47 2.36e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.86 14.41 0.66 3.84e-35 Menarche (age at onset); CESC cis rs7264396 0.790 rs6058290 chr20:34247702 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.74 -0.58 6.79e-26 Total cholesterol levels; CESC cis rs3892630 0.878 rs114224536 chr19:33211232 A/G cg22980127 chr19:33182716 NUDT19 1.06 11.41 0.57 8.86e-25 Red blood cell traits; CESC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs3768617 0.811 rs4350171 chr1:182982148 C/T ch.1.3577855R chr1:183094577 LAMC1 0.66 9.03 0.49 3.66e-17 Fuchs's corneal dystrophy; CESC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg23161317 chr6:28129485 ZNF389 0.51 6.63 0.38 1.85e-10 Depression; CESC cis rs6500602 0.564 rs3747584 chr16:4516092 A/G cg08645402 chr16:4508243 NA 0.43 5.99 0.35 6.91e-9 Schizophrenia; CESC cis rs17253792 0.822 rs10129890 chr14:56040413 A/T cg01858014 chr14:56050164 KTN1 -0.88 -7.51 -0.42 9.24e-13 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09431544 chr19:14629187 DNAJB1 0.64 7.18 0.4 7.15e-12 Gut microbiome composition (summer); CESC cis rs9815354 1.000 rs6790732 chr3:41864872 C/T cg03022575 chr3:42003672 ULK4 0.46 5.29 0.31 2.57e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs9291683 0.507 rs3796837 chr4:10011321 C/G cg02734326 chr4:10020555 SLC2A9 0.43 5.84 0.34 1.49e-8 Bone mineral density; CESC trans rs2018683 0.677 rs12540529 chr7:28969384 A/G cg19402173 chr7:128379420 CALU -0.53 -7.19 -0.4 6.57e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs258892 0.895 rs11953055 chr5:72051503 C/T cg21869765 chr5:72125136 TNPO1 -0.4 -5.26 -0.31 2.97e-7 Small cell lung carcinoma; CESC cis rs1008375 0.897 rs67455495 chr4:17665238 A/T cg02297831 chr4:17616191 MED28 -0.53 -6.06 -0.35 4.65e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs7618501 0.573 rs2624824 chr3:50088266 T/C cg21659725 chr3:3221576 CRBN -0.5 -7.03 -0.4 1.79e-11 Intelligence (multi-trait analysis); CESC trans rs17158675 0.793 rs73380806 chr7:83769789 G/A cg02484411 chr2:493514 NA -0.76 -6.02 -0.35 5.94e-9 Obesity-related traits; CESC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg07167872 chr1:205819463 PM20D1 0.75 12.22 0.6 1.55e-27 Menarche (age at onset); CESC cis rs896854 0.517 rs1011796 chr8:95951273 A/G cg23172400 chr8:95962367 TP53INP1 0.42 7.51 0.42 8.96e-13 Type 2 diabetes; CESC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg12310025 chr6:25882481 NA -0.55 -8.88 -0.48 1.07e-16 Blood metabolite levels; CESC cis rs2251381 0.750 rs2251087 chr21:30527999 C/T cg24692254 chr21:30365293 RNF160 0.78 10.6 0.55 4.11e-22 Selective IgA deficiency; CESC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg06456125 chr7:65229604 NA 0.46 6.03 0.35 5.44e-9 Aortic root size; CESC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.96 0.52 4.77e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg24110177 chr3:50126178 RBM5 0.52 7.23 0.41 5.03e-12 Intelligence (multi-trait analysis); CESC trans rs61931739 0.500 rs11053261 chr12:34530810 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC cis rs561341 1.000 rs7216102 chr17:30259450 A/G cg13647721 chr17:30228624 UTP6 0.49 5.11 0.3 6.17e-7 Hip circumference adjusted for BMI; CESC cis rs56091001 0.528 rs9616387 chr22:50313219 G/A cg02269571 chr22:50332266 NA -0.83 -7.16 -0.4 8.03e-12 Acne (severe); CESC trans rs7980799 0.905 rs4244865 chr12:33511917 C/T cg26384229 chr12:38710491 ALG10B -0.47 -6.4 -0.37 6.93e-10 Heart rate;Heart rate variability traits (RMSSD); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23325670 chr19:17337031 OCEL1 0.61 6.92 0.39 3.35e-11 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs316327 chr7:65609201 G/T cg18252515 chr7:66147081 NA 1.31 12.94 0.62 5.13e-30 Diabetic kidney disease; CESC cis rs1707322 1.000 rs10890353 chr1:46298383 G/T cg05343316 chr1:45956843 TESK2 0.41 5.05 0.3 8.05e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg26314531 chr2:26401878 FAM59B -0.85 -9.04 -0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs7582720 0.943 rs72934734 chr2:203739970 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6460942 1.000 rs62448566 chr7:12403662 G/A cg13733410 chr7:12443478 VWDE -0.53 -5.33 -0.31 2.12e-7 Coronary artery disease; CESC cis rs2040771 0.804 rs7286849 chr22:19223579 C/A cg02655711 chr22:19163373 SLC25A1 0.41 6.03 0.35 5.51e-9 Metabolite levels (small molecules and protein measures); CESC cis rs938554 0.784 rs13131257 chr4:9981889 T/C cg00071950 chr4:10020882 SLC2A9 0.47 5.64 0.33 4.32e-8 Blood metabolite levels; CESC cis rs2760061 0.599 rs644794 chr1:228148670 T/C cg01973587 chr1:228161476 NA 0.4 6.22 0.36 1.97e-9 Diastolic blood pressure; CESC trans rs561341 0.883 rs1034626 chr17:30219500 C/G cg20587970 chr11:113659929 NA 1.0 12.42 0.61 3.24e-28 Hip circumference adjusted for BMI; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22829908 chr10:21814466 C10orf140 0.46 6.34 0.36 9.92e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg07936489 chr17:37558343 FBXL20 -0.8 -11.95 -0.59 1.31e-26 Glomerular filtration rate (creatinine); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09010904 chr3:51573036 NA -0.43 -6.26 -0.36 1.54e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2070997 0.607 rs11244147 chr9:133677168 T/G cg11464064 chr9:133710261 ABL1 0.61 7.01 0.4 2e-11 Response to amphetamines; CESC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.51 0.37 3.75e-10 Bipolar disorder; CESC cis rs6964587 0.692 rs4729018 chr7:91644613 C/T cg01689657 chr7:91764605 CYP51A1 0.26 5.04 0.3 8.66e-7 Breast cancer; CESC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.85 9.33 0.5 4.33e-18 Platelet count; CESC cis rs1348850 0.526 rs10930802 chr2:178460095 A/G cg23306229 chr2:178417860 TTC30B 0.73 6.71 0.38 1.2e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9911578 1.000 rs1057068 chr17:56598439 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.05 -0.3 8.12e-7 Intelligence (multi-trait analysis); CESC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg09323728 chr8:95962352 TP53INP1 -0.44 -10.13 -0.53 1.37e-20 Type 2 diabetes; CESC cis rs7512552 0.839 rs11587575 chr1:150451863 T/C cg15654264 chr1:150340011 RPRD2 0.39 5.09 0.3 6.71e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs6496667 0.779 rs8041401 chr15:90958545 A/G cg13834112 chr15:90361639 NA 0.39 5.06 0.3 7.7300000000000005e-07 Rheumatoid arthritis; CESC cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg25894440 chr7:65020034 NA -0.61 -5.3 -0.31 2.42e-7 Diabetic kidney disease; CESC cis rs8044868 0.530 rs12446480 chr16:72056757 A/G cg01557791 chr16:72042693 DHODH -0.46 -6.39 -0.37 7.23e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs4722166 0.630 rs6461667 chr7:22796743 A/G cg05472934 chr7:22766657 IL6 0.85 10.24 0.53 6.04e-21 Lung cancer; CESC trans rs61931739 0.534 rs35056575 chr12:34142914 A/T cg13010199 chr12:38710504 ALG10B 0.48 6.01 0.35 6.15e-9 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.45 0.32 1.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4077515 0.743 rs3812571 chr9:139275294 G/C cg14169450 chr9:139327907 INPP5E 0.42 5.9 0.34 1.1e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs10242455 0.702 rs17161726 chr7:99008395 C/G cg18809830 chr7:99032528 PTCD1 -0.83 -6.09 -0.35 4e-9 Blood metabolite levels; CESC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.13 0.81 3.58e-62 Prudent dietary pattern; CESC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg23758822 chr17:41437982 NA 0.99 16.81 0.72 1.2e-43 Menopause (age at onset); CESC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg02462569 chr6:150064036 NUP43 -0.36 -5.14 -0.3 5.27e-7 Lung cancer; CESC cis rs4728302 0.869 rs12707129 chr7:133593177 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.33 0.31 2.05e-7 Intelligence;Intelligence (multi-trait analysis); CESC trans rs11039798 1.000 rs12281162 chr11:48650491 T/C cg15704280 chr7:45808275 SEPT13 0.67 6.36 0.36 8.67e-10 Axial length; CESC cis rs12618769 0.597 rs4069739 chr2:99049528 G/C cg10123293 chr2:99228465 UNC50 0.39 5.16 0.3 4.88e-7 Bipolar disorder; CESC cis rs7580658 0.613 rs6754999 chr2:128195387 G/A cg10021288 chr2:128175891 PROC -0.39 -5.62 -0.33 4.9e-8 Protein C levels; CESC cis rs501120 1.000 rs665855 chr10:44757751 T/C cg09554077 chr10:44749378 NA 0.52 6.91 0.39 3.59e-11 Coronary artery disease;Coronary heart disease; CESC cis rs7927592 0.673 rs2510392 chr11:68394457 C/G cg16797656 chr11:68205561 LRP5 0.5 7.39 0.41 1.94e-12 Total body bone mineral density; CESC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg07701084 chr6:150067640 NUP43 0.45 6.39 0.37 7.37e-10 Lung cancer; CESC cis rs4919694 1.000 rs12242000 chr10:104702413 A/C cg04362960 chr10:104952993 NT5C2 0.78 6.58 0.37 2.5e-10 Arsenic metabolism; CESC cis rs8062405 0.755 rs62034355 chr16:28581038 G/C cg07382826 chr16:28625726 SULT1A1 0.39 6.29 0.36 1.34e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg18769074 chr3:133464867 TF 0.32 5.89 0.34 1.19e-8 Iron status biomarkers; CESC cis rs7904368 0.806 rs4612698 chr10:16855070 C/A cg23933602 chr10:16859644 RSU1 0.76 7.15 0.4 8.52e-12 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs684232 0.602 rs2160955 chr17:560604 T/C cg15660573 chr17:549704 VPS53 -0.82 -12.07 -0.6 4.98e-27 Prostate cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11346541 chr1:228327680 GUK1 -0.51 -6.01 -0.35 6.19e-9 Ulcerative colitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11327004 chr7:645500 PRKAR1B -0.42 -6.9 -0.39 3.85e-11 Gambling; CESC cis rs929354 0.713 rs1034785 chr7:157002383 T/C cg05182265 chr7:156933206 UBE3C -0.5 -7.2 -0.4 6.07e-12 Body mass index; CESC cis rs10832963 1.000 rs11024739 chr11:18645843 A/C cg09201001 chr11:18656081 SPTY2D1 -0.82 -12.46 -0.61 2.29e-28 Breast cancer; CESC cis rs7246657 0.943 rs28402338 chr19:37833923 G/A cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.26e-9 Coronary artery calcification; CESC cis rs7100689 0.622 rs10736344 chr10:82133955 T/C cg00277334 chr10:82204260 NA -0.59 -7.81 -0.43 1.34e-13 Post bronchodilator FEV1; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg17157516 chr1:35332203 DLGAP3 -0.44 -6.06 -0.35 4.6e-9 Height; CESC cis rs2070488 0.965 rs4679053 chr3:38523495 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.94 17.3 0.73 2.12e-45 Electrocardiographic conduction measures; CESC cis rs863345 0.604 rs6664542 chr1:158462431 G/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.29 -0.41 3.49e-12 Pneumococcal bacteremia; CESC cis rs911555 0.755 rs8018400 chr14:103901085 A/G cg12935359 chr14:103987150 CKB 0.62 9.1 0.49 2.3e-17 Intelligence (multi-trait analysis); CESC cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg27165867 chr14:105738592 BRF1 -0.53 -5.99 -0.35 6.95e-9 Mean platelet volume;Platelet distribution width; CESC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg06028605 chr16:24865363 SLC5A11 -0.56 -7.83 -0.43 1.2e-13 Intelligence (multi-trait analysis); CESC cis rs501120 1.000 rs527785 chr10:44762686 G/A cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.1e-11 Coronary artery disease;Coronary heart disease; CESC cis rs13242816 1.000 rs34325296 chr7:116122409 C/T cg04696780 chr7:116139425 CAV2 -0.59 -5.23 -0.31 3.42e-7 P wave duration; CESC cis rs12136530 0.774 rs58952060 chr1:19774582 G/A cg01832549 chr1:19774989 CAPZB -0.47 -6.84 -0.39 5.52e-11 Lead levels in blood; CESC cis rs8014204 0.604 rs11159109 chr14:75389074 G/A cg26191576 chr14:75389716 RPS6KL1 -0.4 -5.59 -0.32 5.75e-8 Caffeine consumption; CESC cis rs10465746 0.967 rs28445286 chr1:84430483 A/G cg10977910 chr1:84465055 TTLL7 0.46 6.18 0.35 2.45e-9 Obesity-related traits; CESC cis rs9916302 0.904 rs7221875 chr17:37543328 G/A cg00129232 chr17:37814104 STARD3 0.59 7.8 0.43 1.41e-13 Glomerular filtration rate (creatinine); CESC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg01416388 chr22:39784598 NA 0.45 5.67 0.33 3.73e-8 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25739137 chr3:183851986 EIF2B5 0.68 8.09 0.45 2.1e-14 Gut microbiome composition (summer); CESC cis rs11190604 1.000 rs17113137 chr10:102241998 G/C cg07080220 chr10:102295463 HIF1AN 0.58 5.8 0.34 1.91e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs965513 1.000 rs10739496 chr9:100552559 C/T cg13688889 chr9:100608707 NA -0.58 -8.35 -0.46 3.89e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg24733560 chr20:60626293 TAF4 0.45 6.44 0.37 5.45e-10 Body mass index; CESC cis rs7412746 0.611 rs3768018 chr1:150723747 T/C cg17724175 chr1:150552817 MCL1 0.42 6.34 0.36 9.98e-10 Melanoma; CESC cis rs847577 0.748 rs940432 chr7:97716483 G/A cg21770322 chr7:97807741 LMTK2 0.64 10.52 0.54 7.29e-22 Breast cancer; CESC cis rs881375 0.678 rs10760130 chr9:123701990 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.54 0.42 7.68e-13 Rheumatoid arthritis; CESC cis rs3008870 1.000 rs2815351 chr1:67477980 A/G cg11518657 chr1:67396239 MIER1 0.49 5.44 0.32 1.21e-7 Lymphocyte percentage of white cells; CESC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg26335602 chr6:28129616 ZNF389 0.52 6.78 0.38 7.92e-11 Depression; CESC cis rs36051895 0.695 rs62541534 chr9:5028921 C/G cg02405213 chr9:5042618 JAK2 -0.47 -5.46 -0.32 1.08e-7 Pediatric autoimmune diseases; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18268492 chr10:99185986 PGAM1 -0.49 -6.21 -0.36 2.02e-9 Ulcerative colitis; CESC cis rs8038465 1.000 rs8041181 chr15:73982336 C/T cg15420318 chr15:73925796 NPTN 0.43 6.0 0.35 6.44e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3820928 0.874 rs6740108 chr2:227889559 G/T cg11843606 chr2:227700838 RHBDD1 0.52 6.94 0.39 3.08e-11 Pulmonary function; CESC cis rs6540559 0.673 rs17317411 chr1:209961314 C/T cg21951975 chr1:209979733 IRF6 -0.58 -6.64 -0.38 1.77e-10 Cleft lip with or without cleft palate; CESC cis rs3008870 1.000 rs2755244 chr1:67484470 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -13.89 -0.65 2.42e-33 Lymphocyte percentage of white cells; CESC cis rs2280018 0.963 rs12928424 chr16:15150773 C/G cg07549590 chr16:15018862 NA -0.49 -8.03 -0.44 3.22e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.9e-10 Bipolar disorder; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg10329334 chr7:128767475 LOC407835 -0.45 -6.0 -0.35 6.5e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs10899021 0.920 rs7122710 chr11:74323175 C/T cg25880958 chr11:74394337 NA -0.76 -7.95 -0.44 5.53e-14 Response to metformin (IC50); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09090048 chr11:134093731 VPS26B;NCAPD3 0.61 7.5 0.42 9.67e-13 Gut microbiome composition (summer); CESC cis rs10779751 0.575 rs2791655 chr1:11128654 A/G cg08854313 chr1:11322531 MTOR -0.66 -8.63 -0.47 5.96e-16 Body mass index; CESC cis rs847577 0.609 rs11763970 chr7:97817321 A/G cg21770322 chr7:97807741 LMTK2 0.86 14.9 0.68 6.85e-37 Breast cancer; CESC cis rs8058578 1.000 rs7198250 chr16:30746822 C/A cg02466173 chr16:30829666 NA -0.41 -6.69 -0.38 1.3100000000000001e-10 Multiple myeloma; CESC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg17279839 chr7:150038598 RARRES2 0.48 5.75 0.33 2.5e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs2239547 0.563 rs2581820 chr3:53020544 A/G cg11645453 chr3:52864694 ITIH4 -0.32 -5.68 -0.33 3.63e-8 Schizophrenia; CESC cis rs11247915 0.501 rs34209692 chr1:26608782 C/T cg00852783 chr1:26633632 UBXN11 0.41 5.12 0.3 5.9e-7 Obesity-related traits; CESC cis rs10463316 0.894 rs6579862 chr5:150761717 T/G cg03212797 chr5:150827313 SLC36A1 -0.44 -5.68 -0.33 3.53e-8 Metabolite levels (Pyroglutamine); CESC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg07677032 chr17:61819896 STRADA 0.42 5.28 0.31 2.69e-7 Height; CESC cis rs754466 0.580 rs11002293 chr10:79537965 C/T cg17075019 chr10:79541650 NA -0.88 -13.82 -0.65 4.32e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs703842 0.928 rs724834 chr12:58180416 G/C cg18357645 chr12:58087776 OS9 -0.41 -5.67 -0.33 3.8e-8 Multiple sclerosis; CESC cis rs1461503 0.932 rs56778812 chr11:122840491 C/T cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs11676348 0.967 rs4674258 chr2:218990586 C/T cg00012203 chr2:219082015 ARPC2 -0.55 -7.09 -0.4 1.19e-11 Ulcerative colitis; CESC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg01416388 chr22:39784598 NA -0.54 -6.37 -0.36 8.41e-10 Intelligence (multi-trait analysis); CESC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg02038168 chr22:39784481 NA -0.62 -7.32 -0.41 2.91e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs11203032 0.831 rs10887927 chr10:90940687 T/C cg16672925 chr10:90967113 CH25H 0.68 6.99 0.39 2.24e-11 Heart failure; CESC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg12311346 chr5:56204834 C5orf35 -0.71 -8.69 -0.47 3.8e-16 Initial pursuit acceleration; CESC cis rs3733585 0.673 rs4314284 chr4:9956096 C/T cg11266682 chr4:10021025 SLC2A9 -0.57 -10.86 -0.56 5.66e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1577917 1.000 rs68171315 chr6:86707400 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.36 -0.36 8.63e-10 Response to antipsychotic treatment; CESC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs9837602 0.882 rs6807176 chr3:99760864 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.5 7.23 0.41 5.26e-12 Breast cancer; CESC cis rs634534 0.622 rs531612 chr11:65705432 C/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.56 -7.2 -0.4 6.39e-12 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs589448 0.872 rs315111 chr12:69784695 G/A cg22834771 chr12:69754056 YEATS4 -0.57 -7.62 -0.42 4.38e-13 Cerebrospinal fluid biomarker levels; CESC cis rs597539 0.690 rs615644 chr11:68621806 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 9.45 0.5 1.91e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.69 6.11 0.35 3.54e-9 Platelet count; CESC cis rs963731 0.649 rs6752850 chr2:39220655 C/T cg04010122 chr2:39346883 SOS1 -0.71 -5.28 -0.31 2.65e-7 Corticobasal degeneration; CESC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg11890956 chr21:40555474 PSMG1 1.15 22.06 0.8 6.3e-62 Cognitive function; CESC cis rs3820928 0.874 rs3752896 chr2:227886925 C/T cg11843606 chr2:227700838 RHBDD1 -0.45 -5.93 -0.34 9.66e-9 Pulmonary function; CESC cis rs6142102 0.517 rs6142050 chr20:32527128 G/A cg08999081 chr20:33150536 PIGU 0.35 5.26 0.31 3.03e-7 Skin pigmentation; CESC cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.51 0.46 1.33e-15 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 0.510 rs73016876 chr5:244475 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.23 0.31 3.45e-7 Breast cancer; CESC cis rs11166629 1.000 rs6577713 chr8:135645592 C/A cg27224718 chr8:135614730 ZFAT 0.51 6.34 0.36 9.8e-10 Smoking quantity; CESC cis rs9467711 0.659 rs3823158 chr6:26463271 T/A cg14345882 chr6:26364793 BTN3A2 0.65 5.57 0.32 6.18e-8 Autism spectrum disorder or schizophrenia; CESC cis rs9309711 0.736 rs9678647 chr2:3497036 A/G cg10845886 chr2:3471009 TTC15 0.59 7.54 0.42 7.56e-13 Neurofibrillary tangles; CESC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg19592336 chr6:28129416 ZNF389 0.59 7.78 0.43 1.63e-13 Depression; CESC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg00166722 chr3:10149974 C3orf24 0.54 6.89 0.39 4.08e-11 Alzheimer's disease; CESC cis rs116095464 0.558 rs7715108 chr5:264661 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.86e-15 Breast cancer; CESC cis rs28374715 0.635 rs8023530 chr15:41647775 T/C cg02330683 chr15:41787940 ITPKA 0.43 5.78 0.33 2.11e-8 Ulcerative colitis; CESC cis rs12464559 0.579 rs11682909 chr2:152651592 A/G cg01189475 chr2:152685088 ARL5A 0.66 5.81 0.34 1.74e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs17293817 0.617 rs2387658 chr10:1423905 A/C cg04271617 chr10:1416546 ADARB2 -0.31 -5.19 -0.3 4.24e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs453301 0.652 rs2043129 chr8:8825504 C/G cg15556689 chr8:8085844 FLJ10661 0.43 5.03 0.3 9.04e-7 Joint mobility (Beighton score); CESC cis rs2797160 1.000 rs2211420 chr6:125995549 A/G cg05901451 chr6:126070800 HEY2 -0.46 -6.77 -0.38 8.46e-11 Endometrial cancer; CESC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg03185022 chr7:2884158 GNA12 -0.43 -5.22 -0.31 3.55e-7 Height; CESC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg24296786 chr1:45957014 TESK2 0.62 8.24 0.45 8.18e-15 High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01227078 chr5:110074645 SLC25A46 0.54 6.09 0.35 3.89e-9 Gut microbiome composition (summer); CESC cis rs2479724 0.935 rs1887718 chr6:41857691 C/T cg17623882 chr6:41773611 USP49 -0.41 -5.91 -0.34 1.07e-8 Menarche (age at onset); CESC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg19592336 chr6:28129416 ZNF389 0.48 7.01 0.4 2e-11 Parkinson's disease; CESC cis rs2625529 0.652 rs2957728 chr15:72236432 G/T cg16672083 chr15:72433130 SENP8 0.42 6.35 0.36 9.2e-10 Red blood cell count; CESC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.16 0.3 4.77e-7 Personality dimensions; CESC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg17949981 chr6:28129498 ZNF389 0.44 5.58 0.32 5.97e-8 Depression; CESC cis rs7605827 0.893 rs741437 chr2:15626327 A/G cg19274914 chr2:15703543 NA 0.36 6.42 0.37 6.36e-10 Educational attainment (years of education); CESC cis rs11122272 0.735 rs1076804 chr1:231498460 T/C cg06096015 chr1:231504339 EGLN1 0.43 6.27 0.36 1.47e-9 Hemoglobin concentration; CESC cis rs4566357 1.000 rs4566357 chr2:227922015 C/T cg11843606 chr2:227700838 RHBDD1 0.39 5.05 0.3 8.42e-7 Coronary artery disease; CESC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg09177884 chr7:1199841 ZFAND2A -0.54 -7.33 -0.41 2.83e-12 Longevity;Endometriosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11620074 chr11:33722319 C11orf91 0.5 6.63 0.38 1.9e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2228479 0.702 rs17233441 chr16:89817998 C/G cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.74 -0.33 2.55e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs4730250 0.707 rs257373 chr7:106798290 G/A cg02696742 chr7:106810147 HBP1 -0.55 -5.18 -0.3 4.32e-7 Osteoarthritis; CESC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg12463550 chr7:65579703 CRCP 0.51 6.36 0.36 8.66e-10 Aortic root size; CESC cis rs2282802 0.651 rs6863474 chr5:139630862 C/T cg26211634 chr5:139558579 C5orf32 0.53 7.66 0.43 3.52e-13 Intelligence (multi-trait analysis); CESC cis rs2380220 0.606 rs4571572 chr6:96004823 T/C cg23517279 chr6:96025343 MANEA 0.54 5.87 0.34 1.28e-8 Behavioural disinhibition (generation interaction); CESC cis rs1545257 0.560 rs7561752 chr2:24643834 A/G cg06627628 chr2:24431161 ITSN2 0.51 6.13 0.35 3.24e-9 Sjögren's syndrome; CESC cis rs6665290 0.669 rs3768419 chr1:227173477 C/G cg10327440 chr1:227177885 CDC42BPA -1.11 -23.48 -0.82 1.07e-66 Myeloid white cell count; CESC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg18758796 chr5:131593413 PDLIM4 0.42 5.61 0.33 5.09e-8 Acylcarnitine levels; CESC cis rs7923609 0.934 rs10761763 chr10:65188318 T/C cg01631684 chr10:65280961 REEP3 -0.44 -5.48 -0.32 9.84e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs9457247 0.967 rs387733 chr6:167409771 C/T cg07741184 chr6:167504864 NA -0.31 -5.56 -0.32 6.71e-8 Crohn's disease; CESC cis rs7927592 0.956 rs7106259 chr11:68298512 T/G cg16797656 chr11:68205561 LRP5 0.38 5.27 0.31 2.88e-7 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18807030 chr7:931980 C7orf20 0.47 6.39 0.37 7.64e-10 Fibrinogen levels; CESC cis rs2040771 0.711 rs361639 chr22:19268024 A/G cg02655711 chr22:19163373 SLC25A1 0.4 5.75 0.33 2.45e-8 Metabolite levels (small molecules and protein measures); CESC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg05368731 chr17:41323189 NBR1 0.78 10.79 0.55 9.37e-23 Menopause (age at onset); CESC cis rs7077164 1.000 rs1227775 chr10:71580862 C/G cg07630274 chr10:71583235 COL13A1 -0.39 -7.65 -0.43 3.62e-13 Non-alcoholic fatty liver disease histology (lobular); CESC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg22968622 chr17:43663579 NA -1.19 -16.0 -0.7 8.93e-41 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg18446336 chr7:2847575 GNA12 -0.37 -5.63 -0.33 4.49e-8 Height; CESC cis rs1707322 0.752 rs7529699 chr1:46134634 C/T cg03146154 chr1:46216737 IPP 0.82 11.51 0.58 3.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9837602 1.000 rs10212525 chr3:99713377 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 7.24 0.41 4.82e-12 Breast cancer; CESC cis rs10489202 0.632 rs149912 chr1:167957803 A/T cg24449463 chr1:168025552 DCAF6 -0.41 -5.23 -0.31 3.46e-7 Schizophrenia; CESC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg23161317 chr6:28129485 ZNF389 0.51 6.56 0.37 2.88e-10 Parkinson's disease; CESC trans rs875971 0.830 rs7799834 chr7:65880694 A/C cg26939375 chr7:64535504 NA 0.47 6.14 0.35 3.07e-9 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04816434 chr15:22945077 CYFIP1 0.54 7.03 0.4 1.77e-11 Fibrinogen levels; CESC cis rs2120019 1.000 rs35736167 chr15:75332002 T/G cg09165964 chr15:75287851 SCAMP5 -0.78 -9.31 -0.5 5.02e-18 Blood trace element (Zn levels); CESC cis rs36051895 0.626 rs10283563 chr9:5075603 C/T cg02405213 chr9:5042618 JAK2 -0.44 -5.4 -0.31 1.48e-7 Pediatric autoimmune diseases; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25750404 chr12:6579648 VAMP1 0.5 6.45 0.37 5.25e-10 Gut microbiota (bacterial taxa); CESC cis rs2236918 1.000 rs851782 chr1:242033783 A/G cg17736920 chr1:242011382 EXO1 0.71 8.87 0.48 1.1e-16 Menopause (age at onset); CESC cis rs9814567 1.000 rs1814337 chr3:134200682 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.08 -0.35 4.15e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6500395 1.000 rs6500395 chr16:48621402 T/C cg04672837 chr16:48644449 N4BP1 0.52 6.64 0.38 1.81e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs208515 0.525 rs12191500 chr6:66668681 A/G cg07460842 chr6:66804631 NA 0.83 10.33 0.54 3.09e-21 Exhaled nitric oxide levels; CESC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 7.26 0.41 4.33e-12 Bipolar disorder; CESC cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg13902645 chr11:5959945 NA -0.66 -7.89 -0.44 8.17e-14 DNA methylation (variation); CESC cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.47 0.46 1.74e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.63e-16 Initial pursuit acceleration; CESC cis rs7247513 0.964 rs12104149 chr19:12721088 A/G cg01871581 chr19:12707946 ZNF490 -0.88 -14.67 -0.67 4.5e-36 Bipolar disorder; CESC cis rs6736093 0.966 rs13033393 chr2:112697632 C/G cg12686935 chr2:112915763 FBLN7 -0.43 -5.56 -0.32 6.75e-8 Coronary artery disease; CESC cis rs9329289 0.510 rs12356215 chr10:2545390 C/G cg15501526 chr10:2543763 NA 0.5 7.88 0.44 8.68e-14 Age-related hearing impairment; CESC cis rs6750795 0.746 rs1667301 chr2:232423717 C/T cg19187155 chr2:232395269 NMUR1 0.68 11.72 0.58 7.8e-26 Height; CESC cis rs9341808 0.527 rs2505946 chr6:80810683 A/G cg08355045 chr6:80787529 NA 0.36 5.72 0.33 2.93e-8 Sitting height ratio; CESC trans rs11165623 0.740 rs11165638 chr1:96921357 C/A cg10631902 chr5:14652156 NA -0.55 -8.24 -0.45 8.07e-15 Hip circumference;Waist circumference; CESC cis rs9951602 0.651 rs2959408 chr18:76681702 T/C cg00806245 chr18:76673096 NA 0.51 6.16 0.35 2.63e-9 Obesity-related traits; CESC trans rs62103177 0.733 rs62096748 chr18:77619699 T/C cg05926928 chr17:57297772 GDPD1 1.2 10.81 0.55 8.31e-23 Opioid sensitivity; CESC cis rs26868 0.742 rs26848 chr16:2263516 A/G cg27608139 chr16:2294856 DCI 0.35 5.03 0.3 9e-7 Height; CESC cis rs1707322 0.721 rs11211165 chr1:46157906 C/T cg05343316 chr1:45956843 TESK2 0.51 6.22 0.36 1.96e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9549260 0.577 rs6563841 chr13:41239178 A/C cg21288729 chr13:41239152 FOXO1 0.68 8.65 0.47 5.17e-16 Red blood cell count; CESC cis rs3026401 0.562 rs762972 chr11:31797603 A/G cg14844989 chr11:31128820 NA 0.51 6.2 0.36 2.14e-9 Body mass index; CESC cis rs7662987 0.540 rs2851257 chr4:100039499 G/C cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg21770322 chr7:97807741 LMTK2 0.54 8.15 0.45 1.45e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg13880726 chr7:1868755 MAD1L1 -0.48 -5.08 -0.3 7.23e-7 Bipolar disorder; CESC trans rs3942852 0.806 rs4752807 chr11:48128751 T/G cg15704280 chr7:45808275 SEPT13 -0.63 -7.33 -0.41 2.76e-12 Acute lymphoblastic leukemia (childhood); CESC trans rs208520 0.586 rs208442 chr6:66900618 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.66 -8.02 -0.44 3.5e-14 Exhaled nitric oxide output; CESC cis rs1059312 1.000 rs7135854 chr12:129279988 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.74 -10.51 -0.54 8.05e-22 Systemic lupus erythematosus; CESC cis rs4604732 0.631 rs34330532 chr1:247626844 G/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1018836 0.632 rs2879361 chr8:91481909 C/T cg16814680 chr8:91681699 NA 0.53 7.42 0.41 1.56e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg10556349 chr10:835070 NA 0.59 5.69 0.33 3.3e-8 Eosinophil percentage of granulocytes; CESC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg26314531 chr2:26401878 FAM59B -0.63 -6.99 -0.39 2.29e-11 Gut microbiome composition (summer); CESC cis rs72781680 0.948 rs72796385 chr2:24170360 T/A cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg04772025 chr11:68637568 NA 0.57 6.65 0.38 1.64e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs62344088 0.744 rs76038312 chr5:229005 A/G cg22857025 chr5:266934 NA -1.28 -7.51 -0.42 8.79e-13 Asthma (childhood onset); CESC cis rs2735413 0.752 rs11642442 chr16:78080800 A/C cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg26314531 chr2:26401878 FAM59B -0.76 -8.49 -0.46 1.47e-15 Gut microbiome composition (summer); CESC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg18225595 chr11:63971243 STIP1 0.52 5.13 0.3 5.55e-7 Mean platelet volume; CESC cis rs938554 0.956 rs12507606 chr4:9934561 C/T cg00071950 chr4:10020882 SLC2A9 -0.4 -5.07 -0.3 7.59e-7 Blood metabolite levels; CESC cis rs4979906 1.000 rs68092325 chr10:79446719 T/A cg00983440 chr10:79422392 NA -0.48 -5.08 -0.3 7.19e-7 Mortality in heart failure; CESC cis rs2236918 1.000 rs1635511 chr1:242026172 C/T cg17736920 chr1:242011382 EXO1 0.71 9.6 0.51 6.2e-19 Menopause (age at onset); CESC cis rs13102973 0.932 rs13112852 chr4:135838470 C/T cg14419869 chr4:135874104 NA 0.34 5.32 0.31 2.26e-7 Subjective well-being; CESC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg08736216 chr1:53307985 ZYG11A 0.43 7.23 0.41 5.21e-12 Monocyte count; CESC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg14773178 chr5:1868261 NA 0.32 5.7 0.33 3.12e-8 Cardiovascular disease risk factors; CESC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.13 -0.3 5.55e-7 Obesity-related traits; CESC cis rs4919694 1.000 rs4917988 chr10:104752830 T/G cg04362960 chr10:104952993 NT5C2 0.74 6.44 0.37 5.71e-10 Arsenic metabolism; CESC cis rs11098499 0.820 rs6534140 chr4:120455311 C/T cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs796364 0.806 rs79333757 chr2:200915716 T/C cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC cis rs11190604 1.000 rs11190572 chr10:102232879 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.68e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs9916302 0.904 rs3744348 chr17:37417575 C/G cg00129232 chr17:37814104 STARD3 -0.57 -7.48 -0.42 1.1e-12 Glomerular filtration rate (creatinine); CESC cis rs9303280 0.773 rs12949100 chr17:38057189 G/A cg19468946 chr17:37922297 IKZF3 -0.41 -5.33 -0.31 2.1e-7 Self-reported allergy; CESC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg07507251 chr3:52567010 NT5DC2 0.35 5.96 0.34 7.85e-9 Bipolar disorder; CESC cis rs4423214 0.959 rs11606033 chr11:71154204 A/G cg05163923 chr11:71159392 DHCR7 0.89 12.95 0.62 4.74e-30 Vitamin D levels; CESC cis rs4722166 0.630 rs1829927 chr7:22779918 G/A cg26061582 chr7:22766209 IL6 0.51 5.55 0.32 6.82e-8 Lung cancer; CESC cis rs3733585 0.673 rs7377578 chr4:9952775 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.43e-8 Cleft plate (environmental tobacco smoke interaction); CESC trans rs66573146 0.831 rs68111914 chr4:6986677 C/T cg07817883 chr1:32538562 TMEM39B 1.21 7.98 0.44 4.38e-14 Granulocyte percentage of myeloid white cells; CESC cis rs748404 0.690 rs2924369 chr15:43777985 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.57 -7.35 -0.41 2.53e-12 Lung cancer; CESC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg04369109 chr6:150039330 LATS1 -0.38 -5.19 -0.3 4.09e-7 Lung cancer; CESC cis rs3008870 0.959 rs3008852 chr1:67383416 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.05 14.93 0.68 5.6e-37 Lymphocyte percentage of white cells; CESC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg03676636 chr4:99064102 C4orf37 0.38 5.31 0.31 2.33e-7 Colonoscopy-negative controls vs population controls; CESC cis rs523522 0.962 rs7488320 chr12:120981630 G/T cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs2249694 1.000 rs4512750 chr10:135358664 A/G cg20169779 chr10:135381914 SYCE1 0.42 5.88 0.34 1.26e-8 Obesity-related traits; CESC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg09699651 chr6:150184138 LRP11 0.49 5.99 0.35 6.72e-9 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23188378 chr11:118901631 SLC37A4 0.55 6.22 0.36 1.98e-9 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.77 10.4 0.54 1.87e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9611565 0.500 rs10775759 chr22:42088158 T/C cg06481639 chr22:41940642 POLR3H 0.6 6.4 0.37 6.86e-10 Vitiligo; CESC cis rs12142240 0.698 rs7515598 chr1:46818479 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg15506890 chr2:3487001 NA -0.48 -6.12 -0.35 3.33e-9 Neurofibrillary tangles; CESC cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg18225595 chr11:63971243 STIP1 0.61 8.59 0.47 7.78e-16 Platelet count; CESC cis rs10911232 0.507 rs4483371 chr1:182988352 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.79e-31 Hypertriglyceridemia; CESC cis rs965469 0.817 rs6515806 chr20:3359138 A/G cg25506879 chr20:3388711 C20orf194 -0.5 -5.4 -0.31 1.46e-7 IFN-related cytopenia; CESC cis rs1348850 0.574 rs11691740 chr2:178445161 A/G cg22681709 chr2:178499509 PDE11A 0.43 5.11 0.3 6.12e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11098499 0.575 rs907204 chr4:120238654 G/A cg25214090 chr10:38739885 LOC399744 0.61 8.51 0.46 1.33e-15 Corneal astigmatism; CESC cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg08213375 chr14:104286397 PPP1R13B 0.33 5.41 0.32 1.4e-7 Reticulocyte count; CESC cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg02487422 chr3:49467188 NICN1 0.45 5.72 0.33 2.9e-8 Parkinson's disease; CESC cis rs8141529 0.748 rs1318026 chr22:29283518 A/G cg15103426 chr22:29168792 CCDC117 0.62 8.01 0.44 3.62e-14 Lymphocyte counts; CESC cis rs854765 0.693 rs9907246 chr17:17770965 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.49 -6.88 -0.39 4.22e-11 Total body bone mineral density; CESC cis rs7208859 0.623 rs11657990 chr17:29124200 C/T cg19761014 chr17:28927070 LRRC37B2 0.8 6.59 0.38 2.31e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2247341 1.000 rs2247341 chr4:1701317 C/T cg07465881 chr4:1713556 SLBP -0.52 -6.65 -0.38 1.67e-10 Hip circumference adjusted for BMI;Height; CESC cis rs8070624 0.543 rs8068175 chr17:17874486 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.6 7.71 0.43 2.59e-13 Total body bone mineral density; CESC cis rs116095464 0.558 rs7356561 chr5:284381 G/C cg20965017 chr5:231967 SDHA -0.46 -5.2 -0.3 4.02e-7 Breast cancer; CESC cis rs7937682 0.681 rs7107378 chr11:111401840 C/A cg09085632 chr11:111637200 PPP2R1B 0.54 6.18 0.35 2.47e-9 Primary sclerosing cholangitis; CESC cis rs6430585 0.702 rs3213890 chr2:136552188 G/A cg07169764 chr2:136633963 MCM6 1.3 17.6 0.73 1.86e-46 Corneal structure; CESC cis rs9325144 0.600 rs1817648 chr12:38733424 C/T cg26384229 chr12:38710491 ALG10B -0.58 -8.64 -0.47 5.27e-16 Morning vs. evening chronotype; CESC cis rs6912958 0.712 rs7755167 chr6:88338752 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.24 -0.31 3.32e-7 Monocyte percentage of white cells; CESC cis rs10771431 0.597 rs7976807 chr12:9352459 G/A cg08997352 chr12:9597637 DDX12 -0.71 -8.89 -0.48 9.87e-17 Breast size; CESC cis rs7071206 0.947 rs1356090 chr10:79395312 T/C cg00983440 chr10:79422392 NA -0.68 -8.11 -0.45 1.92e-14 Bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14712964 chr3:9773672 BRPF1 -0.46 -6.19 -0.36 2.32e-9 Fibrinogen levels; CESC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg18230493 chr5:56204884 C5orf35 -0.78 -8.96 -0.48 6.13e-17 Initial pursuit acceleration; CESC cis rs4919687 0.577 rs12765459 chr10:104465687 G/C cg04362960 chr10:104952993 NT5C2 0.48 5.11 0.3 6.11e-7 Colorectal cancer; CESC cis rs6519955 0.897 rs4073601 chr22:46434686 A/G cg05468064 chr22:46423449 NA 0.42 6.89 0.39 4.03e-11 Dupuytren's disease; CESC cis rs9287719 0.934 rs4629131 chr2:10744159 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs6688613 0.649 rs2294195 chr1:166838281 T/C ch.1.3259774R chr1:166827647 TADA1 0.56 5.38 0.31 1.66e-7 Refractive astigmatism; CESC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg17376030 chr22:41985996 PMM1 -0.77 -8.15 -0.45 1.45e-14 Vitiligo; CESC cis rs12477438 0.501 rs1133977 chr2:99741984 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.78 -13.44 -0.64 9.52e-32 Chronic sinus infection; CESC cis rs6693567 0.545 rs4970922 chr1:150458094 C/A cg09579323 chr1:150459698 TARS2 0.47 5.77 0.33 2.24e-8 Migraine; CESC cis rs4986811 1.000 rs11031781 chr11:32454262 C/T cg27409910 chr11:32454216 WT1 0.45 5.83 0.34 1.57e-8 Rubella-specific interleukin-6 secretion; CESC cis rs1801251 0.835 rs1446310 chr2:233683245 G/C cg25237894 chr2:233734115 C2orf82 -0.36 -6.39 -0.37 7.24e-10 Coronary artery disease; CESC cis rs7103648 1.000 rs10838705 chr11:47424931 G/A cg20307385 chr11:47447363 PSMC3 0.95 16.29 0.71 8.21e-42 Diastolic blood pressure;Systolic blood pressure; CESC trans rs267567 0.626 rs559715 chr3:37570399 A/C ch.2.2685596F chr2:128768557 SAP130 -0.43 -6.0 -0.35 6.49e-9 PR interval; CESC trans rs7922314 0.571 rs61865687 chr10:64726329 C/G cg06935979 chr1:232941706 KIAA1383 -0.66 -5.99 -0.35 6.67e-9 Cutaneous psoriasis; CESC cis rs3008870 0.755 rs1024229 chr1:67512903 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.56 7.05 0.4 1.58e-11 Lymphocyte percentage of white cells; CESC cis rs5753037 0.543 rs131267 chr22:30147861 A/G cg01021169 chr22:30184971 ASCC2 -0.55 -7.8 -0.43 1.39e-13 Type 1 diabetes; CESC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg17427002 chr7:12443146 VWDE -0.53 -5.65 -0.33 4.2e-8 Coronary artery disease; CESC cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1499972 0.618 rs7649429 chr3:117640167 G/C cg07612923 chr3:117604196 NA 0.68 6.27 0.36 1.45e-9 Schizophrenia; CESC cis rs67460515 0.563 rs4679672 chr3:160901020 G/A cg03342759 chr3:160939853 NMD3 -0.54 -7.25 -0.41 4.5e-12 Parkinson's disease; CESC trans rs7448080 0.510 rs330450 chr5:123284140 C/T cg10971134 chr1:56877429 NA 0.93 6.3 0.36 1.21e-9 Alcohol dependence (age at onset); CESC cis rs2637266 1.000 rs2637264 chr10:78322794 A/C cg18941641 chr10:78392320 NA 0.4 7.34 0.41 2.56e-12 Pulmonary function; CESC cis rs634534 0.622 rs624273 chr11:65712413 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.47 5.66 0.33 3.87e-8 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg05564831 chr3:52568323 NT5DC2 0.46 7.29 0.41 3.58e-12 Bipolar disorder; CESC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg24250549 chr1:154909240 PMVK -0.43 -5.83 -0.34 1.59e-8 Prostate cancer; CESC cis rs2836633 0.929 rs11702165 chr21:40035313 C/T cg12884169 chr21:40033163 ERG 0.39 6.27 0.36 1.47e-9 Coronary artery disease; CESC cis rs1707322 0.896 rs809774 chr1:46560244 T/A cg06784218 chr1:46089804 CCDC17 -0.35 -5.94 -0.34 8.74e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6088590 0.561 rs764597 chr20:33161225 C/T cg06115741 chr20:33292138 TP53INP2 0.5 6.52 0.37 3.61e-10 Coronary artery disease; CESC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg15445000 chr17:37608096 MED1 -0.41 -6.74 -0.38 9.82e-11 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.25e-30 Prudent dietary pattern; CESC cis rs7580658 0.891 rs3768866 chr2:128045415 G/A cg10021288 chr2:128175891 PROC -0.41 -6.53 -0.37 3.32e-10 Protein C levels; CESC cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg08213375 chr14:104286397 PPP1R13B 0.32 5.39 0.31 1.55e-7 Reticulocyte count; CESC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg22143856 chr6:28129313 ZNF389 0.53 6.71 0.38 1.2e-10 Depression; CESC cis rs7937682 0.663 rs7116280 chr11:111659111 T/C cg09085632 chr11:111637200 PPP2R1B 0.91 11.19 0.57 4.54e-24 Primary sclerosing cholangitis; CESC cis rs2228479 0.850 rs62054609 chr16:89816569 C/A cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs2074585 0.517 rs11637971 chr15:91079863 A/C cg10434728 chr15:90938212 IQGAP1 -0.32 -5.23 -0.31 3.42e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs2650000 0.798 rs2701175 chr12:121391671 C/A cg25281562 chr12:121454272 C12orf43 -0.46 -5.77 -0.33 2.18e-8 Metabolic traits;LDL cholesterol; CESC cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 1.000 rs6970095 chr7:12403840 G/A cg13733410 chr7:12443478 VWDE -0.53 -5.33 -0.31 2.12e-7 Coronary artery disease; CESC cis rs11785400 0.762 rs7460801 chr8:143730972 C/A cg24634471 chr8:143751801 JRK 0.45 5.78 0.33 2.12e-8 Schizophrenia; CESC cis rs8092503 1.000 rs8085272 chr18:52481583 A/G cg12377874 chr18:52495404 RAB27B -0.35 -5.99 -0.35 6.86e-9 Childhood body mass index; CESC cis rs1050631 0.592 rs1789546 chr18:33725874 A/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.48 6.28 0.36 1.37e-9 Esophageal squamous cell cancer (length of survival); CESC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 11.61 0.58 1.82e-25 Alzheimer's disease; CESC cis rs6060717 0.698 rs8123175 chr20:34609872 T/G cg23207816 chr20:34252616 CPNE1;RBM12 0.47 5.66 0.33 3.92e-8 Hip circumference adjusted for BMI; CESC trans rs61931739 0.500 rs73103774 chr12:34482279 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.54 0.54 6.6e-22 Morning vs. evening chronotype; CESC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.75 -0.33 2.42e-8 Total body bone mineral density; CESC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg22638593 chr5:131593259 PDLIM4 0.4 5.13 0.3 5.56e-7 Breast cancer; CESC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg04944784 chr2:26401820 FAM59B 0.96 10.5 0.54 8.76e-22 Gut microbiome composition (summer); CESC cis rs709400 0.663 rs17679475 chr14:103916958 A/G cg12935359 chr14:103987150 CKB -0.55 -8.33 -0.46 4.26e-15 Body mass index; CESC cis rs13382862 0.823 rs12710743 chr2:20880714 T/C cg05481257 chr2:20870211 GDF7 -0.38 -5.83 -0.34 1.61e-8 Abdominal aortic aneurysm; CESC cis rs2012796 0.665 rs72703728 chr14:81834523 G/A cg02996355 chr14:81879375 NA 0.64 7.97 0.44 4.66e-14 Night sleep phenotypes; CESC cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg27478167 chr7:817139 HEATR2 -0.46 -5.34 -0.31 2e-7 Cerebrospinal P-tau181p levels; CESC cis rs17608059 0.504 rs11656981 chr17:13978777 A/G cg27005118 chr17:13972210 COX10 -0.42 -6.36 -0.36 8.57e-10 Temperament; CESC cis rs2295499 0.610 rs17164090 chr4:2676016 G/C cg27239842 chr4:2403781 ZFYVE28 -0.31 -5.2 -0.3 3.96e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg11987759 chr7:65425863 GUSB 0.45 6.06 0.35 4.53e-9 Aortic root size; CESC cis rs6088580 0.524 rs1321306 chr20:33266379 T/A cg08999081 chr20:33150536 PIGU -0.45 -6.29 -0.36 1.33e-9 Glomerular filtration rate (creatinine); CESC cis rs7605827 0.857 rs10185835 chr2:15495763 A/G cg19274914 chr2:15703543 NA 0.33 5.82 0.34 1.69e-8 Educational attainment (years of education); CESC cis rs3768617 0.510 rs2333621 chr1:183090751 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs7762018 0.607 rs75999653 chr6:170066927 A/G cg19338460 chr6:170058176 WDR27 -0.99 -8.06 -0.44 2.62e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2658782 1.000 rs2658782 chr11:93166731 T/G cg15737290 chr11:93063684 CCDC67 0.51 6.48 0.37 4.55e-10 Pulmonary function decline; CESC cis rs6061231 1.000 rs11908473 chr20:60957770 C/G cg24112000 chr20:60950667 NA -0.59 -7.97 -0.44 4.72e-14 Colorectal cancer; CESC trans rs35110281 0.591 rs162390 chr21:44936826 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.7 0.38 1.27e-10 Mean corpuscular volume; CESC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg10295955 chr4:187884368 NA -1.04 -19.32 -0.76 1.73e-52 Lobe attachment (rater-scored or self-reported); CESC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg10295955 chr4:187884368 NA 1.01 19.84 0.77 2.64e-54 Lobe attachment (rater-scored or self-reported); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01644481 chr6:106809170 NA 0.48 6.1 0.35 3.67e-9 Gut microbiota (bacterial taxa); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14532426 chr21:33245908 HUNK -0.47 -6.24 -0.36 1.75e-9 Fibrinogen levels; CESC cis rs9309473 0.687 rs6706235 chr2:73613558 C/G cg20560298 chr2:73613845 ALMS1 -0.5 -6.75 -0.38 9.21e-11 Metabolite levels; CESC cis rs2109514 0.967 rs55883210 chr7:116160524 G/A cg12739419 chr7:116140593 CAV2 -0.36 -6.55 -0.37 3.02e-10 Prevalent atrial fibrillation; CESC cis rs12476592 1.000 rs12476592 chr2:63850098 G/C cg10828910 chr2:63850056 LOC388955 -0.49 -5.26 -0.31 2.94e-7 Childhood ear infection; CESC cis rs3767633 0.925 rs1806594 chr1:161858860 T/C cg09175582 chr1:161736000 ATF6 0.86 6.87 0.39 4.53e-11 IgG glycosylation; CESC cis rs36051895 0.623 rs10283467 chr9:5244356 C/G cg02405213 chr9:5042618 JAK2 0.53 6.39 0.37 7.61e-10 Pediatric autoimmune diseases; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26468130 chr11:64053342 BAD;GPR137 -0.44 -6.03 -0.35 5.54e-9 Fibrinogen levels; CESC cis rs709400 0.659 rs7160366 chr14:103944137 C/T cg12935359 chr14:103987150 CKB -0.54 -8.02 -0.44 3.39e-14 Body mass index; CESC cis rs4924935 1.000 rs9905565 chr17:18758641 C/T cg26378065 chr17:18585709 ZNF286B 0.47 5.91 0.34 1.03e-8 Pancreatic cancer; CESC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.23 -0.36 1.86e-9 Schizophrenia; CESC cis rs950169 0.545 rs4354897 chr15:84644971 T/C cg17507749 chr15:85114479 UBE2QP1 0.62 6.01 0.35 6.07e-9 Schizophrenia; CESC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg16145915 chr7:1198662 ZFAND2A -0.47 -6.6 -0.38 2.2e-10 Longevity;Endometriosis; CESC cis rs13191362 0.507 rs2846566 chr6:163059714 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.52 -6.06 -0.35 4.74e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10589950 chr19:36231534 TMEM149 -0.56 -6.33 -0.36 1.02e-9 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16416718 chr1:6844519 CAMTA1 -0.47 -6.05 -0.35 5.04e-9 Ulcerative colitis; CESC trans rs11098499 0.913 rs67073020 chr4:120152557 C/T cg25214090 chr10:38739885 LOC399744 0.64 8.35 0.46 3.93e-15 Corneal astigmatism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11074549 chr14:75642944 TMED10 -0.51 -6.87 -0.39 4.56e-11 Fibrinogen levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26105702 chr2:209120195 IDH1 -0.46 -6.23 -0.36 1.85e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs763121 0.853 rs2235230 chr22:39124467 A/G cg14440974 chr22:39074834 NA 0.45 6.08 0.35 4.21e-9 Menopause (age at onset); CESC cis rs713587 0.571 rs563590 chr2:25331172 A/G cg01884057 chr2:25150051 NA -0.3 -5.03 -0.3 8.85e-7 Body mass index in non-asthmatics; CESC cis rs9309473 1.000 rs2056486 chr2:73717567 G/T cg20560298 chr2:73613845 ALMS1 -0.47 -6.29 -0.36 1.28e-9 Metabolite levels; CESC cis rs10089 1.000 rs10057122 chr5:127512063 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.28 0.5 6.38e-18 Ileal carcinoids; CESC cis rs477692 0.673 rs579952 chr10:131356084 A/T cg05714579 chr10:131428358 MGMT -0.39 -5.06 -0.3 8.02e-7 Response to temozolomide; CESC cis rs4835473 0.800 rs1988209 chr4:144912633 C/A cg25736465 chr4:144833511 NA 0.44 6.64 0.38 1.8e-10 Immature fraction of reticulocytes; CESC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg00129232 chr17:37814104 STARD3 -0.54 -7.13 -0.4 9.71e-12 Glomerular filtration rate (creatinine); CESC cis rs7084402 0.967 rs7921371 chr10:60330531 G/C cg07615347 chr10:60278583 BICC1 -0.55 -8.29 -0.45 5.55e-15 Refractive error; CESC cis rs11809207 0.574 rs2783633 chr1:26505265 A/G cg00147160 chr1:26503991 CNKSR1 0.27 5.14 0.3 5.4e-7 Height; CESC cis rs473651 0.503 rs515342 chr2:239367296 A/G cg01753270 chr2:239240285 TRAF3IP1 -0.45 -5.82 -0.34 1.68e-8 Multiple system atrophy; CESC cis rs9543976 1.000 rs55927305 chr13:76135349 A/G cg01531495 chr13:76123901 UCHL3 -0.56 -5.52 -0.32 8.15e-8 Diabetic retinopathy; CESC cis rs1670533 0.585 rs6827206 chr4:1065071 A/T cg27284194 chr4:1044797 NA 0.48 6.06 0.35 4.69e-9 Recombination rate (females); CESC cis rs11031096 0.655 rs56172516 chr11:4182004 G/T cg18678763 chr11:4115507 RRM1 -0.43 -5.95 -0.34 8.24e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg11764359 chr7:65958608 NA -0.7 -9.25 -0.49 7.64e-18 Aortic root size; CESC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg02725872 chr8:58115012 NA -0.38 -5.09 -0.3 6.64e-7 Developmental language disorder (linguistic errors); CESC cis rs12136530 0.774 rs4912096 chr1:19775113 T/C cg01832549 chr1:19774989 CAPZB -0.47 -6.82 -0.39 6.32e-11 Lead levels in blood; CESC cis rs6912958 0.781 rs3918467 chr6:88180388 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.45 -6.16 -0.35 2.72e-9 Monocyte percentage of white cells; CESC cis rs4835473 0.831 rs7694353 chr4:144894940 T/G cg25736465 chr4:144833511 NA 0.39 5.97 0.34 7.43e-9 Immature fraction of reticulocytes; CESC cis rs35110281 0.715 rs2838353 chr21:45119228 C/T cg21573476 chr21:45109991 RRP1B -0.51 -7.29 -0.41 3.61e-12 Mean corpuscular volume; CESC cis rs11098499 0.908 rs9995234 chr4:120321827 A/G cg09307838 chr4:120376055 NA 0.9 11.83 0.59 3.4e-26 Corneal astigmatism; CESC cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg24130564 chr14:104152367 KLC1 -0.48 -6.36 -0.36 8.88e-10 Reticulocyte count; CESC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg22823121 chr1:150693482 HORMAD1 0.47 6.57 0.37 2.6e-10 Melanoma; CESC cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg23711669 chr6:146136114 FBXO30 -1.01 -15.7 -0.69 1.03e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs3105593 1.000 rs3131580 chr15:50854926 T/G cg08437265 chr15:50716283 USP8 0.4 5.15 0.3 5.13e-7 QT interval; CESC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg14664628 chr15:75095509 CSK -0.58 -8.21 -0.45 9.96e-15 Breast cancer; CESC cis rs4727963 0.846 rs6466852 chr7:122706689 T/G cg03640110 chr7:122635026 TAS2R16 -0.37 -5.7 -0.33 3.11e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.5 0.37 3.92e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01777103 chr8:145550585 DGAT1 0.54 6.28 0.36 1.36e-9 Gut microbiome composition (summer); CESC trans rs9354308 0.933 rs2802062 chr6:66561973 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 7.82 0.43 1.27e-13 Metabolite levels; CESC cis rs2075371 0.611 rs34573600 chr7:134018937 C/T cg20476274 chr7:133979776 SLC35B4 0.58 7.7 0.43 2.73e-13 Mean platelet volume; CESC cis rs2070677 0.932 rs2987786 chr10:135365303 C/T cg20169779 chr10:135381914 SYCE1 -0.71 -8.94 -0.48 6.99e-17 Gout; CESC trans rs9325144 0.600 rs10880934 chr12:38730455 C/T cg23762105 chr12:34175262 ALG10 0.48 6.22 0.36 1.89e-9 Morning vs. evening chronotype; CESC cis rs4835473 0.932 rs5015757 chr4:144659297 C/T cg25736465 chr4:144833511 NA 0.32 5.13 0.3 5.66e-7 Immature fraction of reticulocytes; CESC cis rs3743266 0.507 rs56261931 chr15:60731618 C/T cg22293140 chr15:60689852 ANXA2 -0.66 -7.42 -0.41 1.56e-12 Menarche (age at onset); CESC cis rs3540 0.597 rs10152221 chr15:91047664 A/G cg22089800 chr15:90895588 ZNF774 -0.65 -8.95 -0.48 6.18e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs8014204 0.804 rs2241274 chr14:75251331 G/A cg08847533 chr14:75593920 NEK9 0.46 5.87 0.34 1.27e-8 Caffeine consumption; CESC cis rs116095464 0.681 rs9687745 chr5:229309 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.54 5.78 0.33 2.04e-8 Breast cancer; CESC cis rs13095912 0.962 rs11916386 chr3:185308069 G/T cg11274856 chr3:185301563 NA 0.37 6.13 0.35 3.15e-9 Systolic blood pressure; CESC cis rs6540556 0.954 rs7536882 chr1:209936673 C/G cg05527609 chr1:210001259 C1orf107 -0.46 -5.74 -0.33 2.65e-8 Red blood cell count; CESC cis rs568617 0.767 rs2231884 chr11:65656564 C/T cg19792802 chr11:65647270 CTSW 0.38 5.13 0.3 5.55e-7 Crohn's disease; CESC cis rs7827545 1.000 rs6578232 chr8:135565690 G/A cg17885191 chr8:135476712 NA 0.48 6.28 0.36 1.39e-9 Hypertension (SNP x SNP interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22435810 chr17:18164253 SMCR7 0.48 6.16 0.35 2.63e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2645694 0.603 rs2703123 chr4:77821154 C/T cg18351406 chr4:77819688 ANKRD56 0.55 6.89 0.39 4.12e-11 Emphysema distribution in smoking; CESC cis rs4835473 0.932 rs4835455 chr4:144883443 A/C cg25736465 chr4:144833511 NA 0.37 5.29 0.31 2.6e-7 Immature fraction of reticulocytes; CESC cis rs965469 1.000 rs6051723 chr20:3278512 C/A cg25506879 chr20:3388711 C20orf194 -0.58 -6.15 -0.35 2.79e-9 IFN-related cytopenia; CESC cis rs11676348 0.846 rs4674260 chr2:219002376 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.1 -0.35 3.81e-9 Ulcerative colitis; CESC cis rs4642101 0.662 rs3901664 chr3:12824660 T/C cg05775895 chr3:12838266 CAND2 0.39 5.92 0.34 9.97e-9 QRS complex (12-leadsum); CESC cis rs7605827 0.866 rs4668901 chr2:15521677 A/G cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05787931 chr3:52232012 ALAS1 -0.45 -6.4 -0.37 6.82e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4728302 0.838 rs6954700 chr7:133588739 G/A cg10665199 chr7:133106180 EXOC4 0.39 5.43 0.32 1.29e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs34330 0.562 rs10492235 chr12:12851339 T/G cg04607235 chr12:12878440 APOLD1 -0.84 -9.05 -0.49 3.09e-17 Systemic lupus erythematosus; CESC cis rs9611519 0.929 rs9611465 chr22:41426139 G/A cg03806693 chr22:41940476 POLR3H -0.58 -6.03 -0.35 5.58e-9 Neuroticism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15203618 chr11:85646125 NA 0.47 6.61 0.38 2.15e-10 Fibrinogen levels; CESC cis rs9467711 0.790 rs1979 chr6:26377591 G/T cg12826209 chr6:26865740 GUSBL1 0.64 5.41 0.32 1.39e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7949030 0.588 rs2512563 chr11:62311249 C/G cg13298116 chr11:62369859 EML3;MTA2 0.58 8.57 0.47 8.59e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs1799949 0.965 rs4793237 chr17:41436595 A/T cg23758822 chr17:41437982 NA 1.0 17.07 0.72 1.38e-44 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20314660 chr19:14530105 DDX39 -0.5 -6.49 -0.37 4.25e-10 Ulcerative colitis; CESC cis rs6686643 1.000 rs957644 chr1:165616157 C/T cg19407955 chr1:165599744 MGST3 -0.5 -5.12 -0.3 5.84e-7 Total ventricular volume; CESC cis rs4819052 0.580 rs419322 chr21:46551702 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 5.43 0.32 1.3e-7 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09392819 chr2:26568944 SELI;GPR113 0.48 6.31 0.36 1.18e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.81 10.44 0.54 1.35e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3733585 0.638 rs7377625 chr4:9953099 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.58 -0.32 6e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs8077889 0.956 rs17742347 chr17:41846468 A/G cg26893861 chr17:41843967 DUSP3 -0.83 -9.55 -0.51 9.06e-19 Triglycerides; CESC cis rs748404 0.697 rs473016 chr15:43558823 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.61 7.77 0.43 1.69e-13 Lung cancer; CESC cis rs9303401 0.538 rs2240259 chr17:56458129 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.96 10.83 0.55 6.93e-23 Cognitive test performance; CESC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg05373962 chr22:49881684 NA -0.36 -6.25 -0.36 1.65e-9 Monocyte count;Monocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11339840 chr1:203596058 ATP2B4 0.49 6.54 0.37 3.24e-10 Gut microbiota (bacterial taxa); CESC cis rs6502050 0.871 rs6502056 chr17:80070912 C/G cg23985595 chr17:80112537 CCDC57 0.41 6.44 0.37 5.6e-10 Life satisfaction; CESC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg18099408 chr3:52552593 STAB1 -0.32 -5.14 -0.3 5.46e-7 Bipolar disorder; CESC cis rs7020830 0.898 rs997318 chr9:37364094 C/T cg14294708 chr9:37120828 ZCCHC7 1.13 19.5 0.77 3.97e-53 Schizophrenia; CESC cis rs4853012 1.000 rs4853012 chr2:74361290 G/A cg05890377 chr2:74357713 NA 0.72 7.83 0.43 1.16e-13 Gestational age at birth (maternal effect); CESC cis rs933688 0.526 rs2973468 chr5:90540879 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.54 -5.38 -0.31 1.64e-7 Smoking behavior; CESC cis rs6665290 0.904 rs6664955 chr1:227183434 T/C cg10327440 chr1:227177885 CDC42BPA -1.21 -33.23 -0.9 1.68e-96 Myeloid white cell count; CESC cis rs7208859 0.673 rs56146117 chr17:29153325 C/T cg13385521 chr17:29058706 SUZ12P 0.75 6.0 0.35 6.29e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg24549020 chr5:56110836 MAP3K1 -0.5 -6.07 -0.35 4.29e-9 Initial pursuit acceleration; CESC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg24829409 chr8:58192753 C8orf71 -0.72 -8.22 -0.45 9.34e-15 Developmental language disorder (linguistic errors); CESC cis rs1808579 0.839 rs1788808 chr18:21090023 A/G cg14672496 chr18:21087552 C18orf8 0.4 5.64 0.33 4.37e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg08736216 chr1:53307985 ZYG11A 0.32 5.74 0.33 2.63e-8 Monocyte count; CESC cis rs10743315 0.557 rs74465549 chr12:19344365 A/C cg02471346 chr12:19282374 PLEKHA5 0.72 5.43 0.32 1.28e-7 Gut microbiota (bacterial taxa); CESC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.59 -0.32 5.55e-8 Huntington's disease progression; CESC cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg05535760 chr7:792225 HEATR2 0.88 11.02 0.56 1.76e-23 Cerebrospinal P-tau181p levels; CESC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.83 11.64 0.58 1.46e-25 Age-related macular degeneration (geographic atrophy); CESC cis rs6032067 0.929 rs56131549 chr20:43842014 A/T cg11264863 chr20:43835661 SEMG1 0.48 5.26 0.31 2.99e-7 Blood protein levels; CESC cis rs568617 0.953 rs658938 chr11:65651830 A/G cg00576331 chr11:65640516 EFEMP2 0.45 5.3 0.31 2.48e-7 Crohn's disease; CESC cis rs6570726 0.791 rs6902404 chr6:145905254 G/A cg23711669 chr6:146136114 FBXO30 0.84 12.46 0.61 2.29e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs11252926 0.528 rs11252090 chr10:436547 C/T cg16386425 chr10:429943 DIP2C 0.5 6.4 0.37 7.11e-10 Psychosis in Alzheimer's disease; CESC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.22 -0.31 3.64e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs17376456 0.877 rs10476598 chr5:93367281 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 -0.63 -5.5 -0.32 8.79e-8 Diabetic retinopathy; CESC cis rs57083693 0.518 rs12317211 chr12:101704521 C/T cg22051763 chr12:101673672 UTP20 -0.45 -5.69 -0.33 3.4e-8 Alcohol dependence (age at onset); CESC cis rs6456156 0.792 rs10946213 chr6:167516095 A/G cg07741184 chr6:167504864 NA -0.33 -5.94 -0.34 8.82e-9 Primary biliary cholangitis; CESC cis rs7267979 0.966 rs416745 chr20:25438868 T/C cg08601574 chr20:25228251 PYGB 0.37 5.31 0.31 2.31e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg03709012 chr19:19516395 GATAD2A -0.96 -14.2 -0.66 2.12e-34 Tonsillectomy; CESC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg18758796 chr5:131593413 PDLIM4 0.38 5.26 0.31 2.95e-7 Breast cancer; CESC cis rs9399135 0.967 rs4637662 chr6:135298158 T/C cg24558204 chr6:135376177 HBS1L 0.5 6.75 0.38 9.09e-11 Red blood cell count; CESC cis rs1832871 0.711 rs12527510 chr6:158657299 T/G cg07165851 chr6:158734300 TULP4 0.56 5.79 0.34 1.96e-8 Height; CESC cis rs34172651 0.876 rs7186893 chr16:24806420 G/T cg06028605 chr16:24865363 SLC5A11 0.41 6.22 0.36 1.94e-9 Intelligence (multi-trait analysis); CESC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.09 -12.46 -0.61 2.41e-28 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs2265469 chr6:146219049 T/C cg05347473 chr6:146136440 FBXO30 0.55 7.05 0.4 1.57e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs2814021 0.545 rs10994777 chr10:63233988 G/A cg08188886 chr14:105633697 JAG2 0.43 6.38 0.36 7.75e-10 Obesity-related traits; CESC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg26335602 chr6:28129616 ZNF389 0.43 5.88 0.34 1.21e-8 Parkinson's disease; CESC cis rs28735056 0.903 rs56185453 chr18:77638297 A/G cg20368463 chr18:77673604 PQLC1 -0.4 -5.17 -0.3 4.55e-7 Schizophrenia; CESC cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg22590775 chr19:49891494 CCDC155 0.45 5.04 0.3 8.62e-7 Multiple sclerosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08337184 chr19:11558539 PRKCSH 0.46 6.67 0.38 1.48e-10 Fibrinogen levels; CESC trans rs57221529 0.766 rs56278696 chr5:582669 A/G cg25482853 chr8:67687455 SGK3 1.0 9.94 0.52 5.32e-20 Lung disease severity in cystic fibrosis; CESC cis rs11098499 0.865 rs28634456 chr4:120375778 A/G cg24375607 chr4:120327624 NA 0.46 5.66 0.33 3.94e-8 Corneal astigmatism; CESC cis rs1538970 0.748 rs11211137 chr1:46013892 T/A cg03146154 chr1:46216737 IPP 0.52 5.81 0.34 1.81e-8 Platelet count; CESC cis rs3008870 0.920 rs3008865 chr1:67402838 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.02 14.14 0.66 3.43e-34 Lymphocyte percentage of white cells; CESC cis rs9843304 0.616 rs4681177 chr3:149203000 G/T cg20906640 chr3:149182207 NA -0.33 -5.13 -0.3 5.64e-7 Gallstone disease; CESC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg12463550 chr7:65579703 CRCP -0.46 -5.86 -0.34 1.34e-8 Aortic root size; CESC cis rs3760982 0.585 rs8109478 chr19:44298256 C/T cg11993925 chr19:44307056 LYPD5 0.33 5.68 0.33 3.47e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg00129232 chr17:37814104 STARD3 0.51 6.37 0.36 8.22e-10 Glomerular filtration rate (creatinine); CESC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg12311346 chr5:56204834 C5orf35 -0.41 -5.08 -0.3 7.3e-7 Coronary artery disease; CESC cis rs35110281 0.837 rs7279968 chr21:45077398 C/G cg01579765 chr21:45077557 HSF2BP -0.57 -9.97 -0.52 4.43e-20 Mean corpuscular volume; CESC cis rs644799 0.511 rs10831420 chr11:95478209 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.41 5.14 0.3 5.29e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.49 0.42 1.04e-12 Prudent dietary pattern; CESC cis rs3733585 0.673 rs4467563 chr4:9953460 A/T cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg17911788 chr17:44343683 NA -0.43 -6.76 -0.38 8.86e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg22105103 chr4:187893119 NA 0.49 7.23 0.41 5.11e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1580019 0.563 rs896137 chr7:32579345 G/T cg06627557 chr7:32535165 LSM5;AVL9 1.07 18.41 0.75 2.5e-49 Cognitive ability; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03068646 chr9:97136929 HIATL1 -0.45 -6.54 -0.37 3.2e-10 Gambling; CESC cis rs11031096 0.678 rs61899754 chr11:4201312 A/T cg18678763 chr11:4115507 RRM1 -0.39 -5.06 -0.3 7.72e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs4568518 0.740 rs11543650 chr7:18009880 T/C cg03009463 chr7:17980271 SNX13 0.48 6.28 0.36 1.38e-9 Measles; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03956833 chr1:1051711 C1orf159 -0.46 -6.64 -0.38 1.73e-10 Gambling; CESC cis rs11122272 0.735 rs2790893 chr1:231508976 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.78 -0.43 1.63e-13 Hemoglobin concentration; CESC cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg10578991 chr7:12443926 VWDE -0.51 -5.61 -0.33 5.17e-8 Coronary artery disease; CESC cis rs8062405 1.000 rs12446589 chr16:28870962 G/A cg05966235 chr16:28915196 ATP2A1 0.35 5.18 0.3 4.38e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs916888 0.821 rs415430 chr17:44859144 C/T cg14517863 chr17:44321492 NA -0.4 -5.17 -0.3 4.56e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7666738 0.649 rs28865589 chr4:98954279 C/A cg03467027 chr4:99064603 C4orf37 0.45 5.57 0.32 6.34e-8 Colonoscopy-negative controls vs population controls; CESC cis rs79349575 0.715 rs62075844 chr17:47002389 G/A cg26022315 chr17:47021804 SNF8 0.39 5.18 0.3 4.5e-7 Type 2 diabetes; CESC cis rs1461503 0.966 rs1461501 chr11:122844416 A/G cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC cis rs7017914 0.967 rs12680166 chr8:71678638 G/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.22 -0.31 3.65e-7 Bone mineral density; CESC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg00074818 chr8:8560427 CLDN23 0.37 5.43 0.32 1.26e-7 Obesity-related traits; CESC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.04 0.49 3.47e-17 Tonsillectomy; CESC cis rs2414059 0.518 rs3098176 chr15:50781963 T/A cg08437265 chr15:50716283 USP8 0.47 5.91 0.34 1.03e-8 QT interval; CESC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg22823121 chr1:150693482 HORMAD1 0.4 5.64 0.33 4.46e-8 Melanoma; CESC cis rs76419734 0.510 rs2216515 chr4:106750214 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.6 -6.14 -0.35 3.02e-9 Post bronchodilator FEV1; CESC cis rs666930 1.000 rs666930 chr1:120258970 A/G cg19096424 chr1:120255104 PHGDH 0.46 6.03 0.35 5.37e-9 Breast cancer; CESC cis rs561341 1.000 rs72821952 chr17:30248133 T/A cg12193833 chr17:30244370 NA -0.71 -6.37 -0.36 8.43e-10 Hip circumference adjusted for BMI; CESC cis rs11098499 1.000 rs35643470 chr4:120184948 T/C cg09307838 chr4:120376055 NA 0.89 11.91 0.59 1.77e-26 Corneal astigmatism; CESC cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.85 0.48 1.3e-16 Colonoscopy-negative controls vs population controls; CESC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.02 -0.35 5.91e-9 Total body bone mineral density; CESC cis rs2370759 1.000 rs78959390 chr10:32616346 C/T cg01819863 chr10:32635814 EPC1 1.16 12.42 0.61 3.2e-28 Sexual dysfunction (female); CESC cis rs2635047 1.000 rs2635043 chr18:44679769 A/G cg19077165 chr18:44547161 KATNAL2 -0.44 -5.93 -0.34 9.55e-9 Educational attainment; CESC cis rs7267979 0.966 rs4815425 chr20:25398876 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.09 -0.74 3.47e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs1538970 0.816 rs9727262 chr1:45998579 T/G cg05343316 chr1:45956843 TESK2 0.86 11.41 0.57 8.44e-25 Platelet count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02099313 chr1:231114956 TTC13;ARV1 0.5 6.53 0.37 3.39e-10 Gut microbiota (bacterial taxa); CESC cis rs2637266 0.783 rs11001866 chr10:78486774 C/T cg18941641 chr10:78392320 NA 0.45 8.84 0.48 1.41e-16 Pulmonary function; CESC cis rs1185460 0.967 rs1784461 chr11:118937985 G/A cg01677386 chr11:118938358 VPS11 -0.44 -5.63 -0.33 4.69e-8 Coronary artery disease; CESC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg11890956 chr21:40555474 PSMG1 1.17 22.42 0.81 3.65e-63 Cognitive function; CESC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.46 0.42 1.23e-12 Tonsillectomy; CESC cis rs3540 0.533 rs2256110 chr15:90971036 T/C cg10434728 chr15:90938212 IQGAP1 0.41 7.4 0.41 1.8e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg23758822 chr17:41437982 NA 1.03 12.64 0.61 5.44e-29 Menopause (age at onset); CESC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.65 0.33 4.11e-8 Electroencephalogram traits; CESC cis rs5758511 0.680 rs5751243 chr22:42617177 T/C cg00645731 chr22:42541494 CYP2D7P1 0.57 8.51 0.46 1.28e-15 Birth weight; CESC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg22800045 chr5:56110881 MAP3K1 0.49 5.88 0.34 1.24e-8 Coronary artery disease; CESC trans rs3780486 0.505 rs10813958 chr9:33165985 A/G cg04842962 chr6:43655489 MRPS18A 0.67 10.15 0.53 1.16e-20 IgG glycosylation; CESC cis rs7937682 0.889 rs7926485 chr11:111536670 G/A cg22437258 chr11:111473054 SIK2 0.68 9.21 0.49 1e-17 Primary sclerosing cholangitis; CESC cis rs30380 0.587 rs469674 chr5:96130015 G/C cg16492584 chr5:96139282 ERAP1 -0.49 -6.73 -0.38 1.05e-10 Cerebrospinal fluid biomarker levels; CESC cis rs1707322 0.685 rs11211177 chr1:46226349 A/G cg05343316 chr1:45956843 TESK2 0.49 6.21 0.36 2.08e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13763503 chr9:99801410 CTSL2 0.48 6.33 0.36 1.07e-9 Systemic lupus erythematosus; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg12633985 chr6:26056540 HIST1H1C 0.47 6.25 0.36 1.65e-9 Thyroid stimulating hormone; CESC cis rs7635838 0.892 rs9870881 chr3:11447082 A/G cg00170343 chr3:11313890 ATG7 0.42 5.57 0.32 6.23e-8 HDL cholesterol; CESC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg16405210 chr4:1374714 KIAA1530 -0.48 -6.13 -0.35 3.1e-9 Obesity-related traits; CESC cis rs611744 0.608 rs612744 chr8:109245991 G/A cg21045802 chr8:109455806 TTC35 0.46 5.72 0.33 2.92e-8 Dupuytren's disease; CESC cis rs2243480 1.000 rs160634 chr7:65528664 C/T cg12463550 chr7:65579703 CRCP -0.59 -5.19 -0.3 4.22e-7 Diabetic kidney disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07081388 chr14:50065245 PPIL5 -0.54 -6.77 -0.38 8.02e-11 Ulcerative colitis; CESC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg18404041 chr3:52824283 ITIH1 -0.4 -6.73 -0.38 1.02e-10 Bipolar disorder; CESC cis rs7927592 0.956 rs6591341 chr11:68335478 C/T cg01657329 chr11:68192670 LRP5 -0.4 -5.13 -0.3 5.61e-7 Total body bone mineral density; CESC trans rs5769765 0.908 rs9616388 chr22:50313438 T/C cg09872104 chr7:134855509 C7orf49 -0.55 -6.32 -0.36 1.11e-9 Schizophrenia; CESC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg27535305 chr1:53392650 SCP2 0.31 5.51 0.32 8.35e-8 Monocyte count; CESC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg14393609 chr7:65229607 NA 0.53 7.22 0.41 5.48e-12 Calcium levels; CESC cis rs78456975 0.622 rs11896517 chr2:1518112 A/G cg26248373 chr2:1572462 NA -0.53 -5.47 -0.32 1.07e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs654950 0.875 rs116747365 chr1:41994792 C/T cg06885757 chr1:42089581 HIVEP3 -0.44 -6.82 -0.39 6.21e-11 Airway imaging phenotypes; CESC cis rs950027 0.620 rs2486274 chr15:45666228 G/T cg21132104 chr15:45694354 SPATA5L1 0.67 8.55 0.46 1.01e-15 Response to fenofibrate (adiponectin levels); CESC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg04155289 chr7:94953770 PON1 -0.49 -6.93 -0.39 3.15e-11 Paraoxonase activity; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10891888 chr12:46765615 SLC38A2 -0.4 -6.1 -0.35 3.84e-9 Gambling; CESC cis rs36051895 0.564 rs7874624 chr9:5179865 A/G cg02405213 chr9:5042618 JAK2 -0.51 -6.56 -0.37 2.87e-10 Pediatric autoimmune diseases; CESC cis rs9583531 0.657 rs7337126 chr13:111376788 A/G cg15841412 chr13:111365552 ING1 0.44 5.42 0.32 1.37e-7 Coronary artery disease; CESC cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg03146154 chr1:46216737 IPP -0.45 -5.58 -0.32 5.83e-8 High light scatter reticulocyte count; CESC cis rs4891159 0.527 rs689642 chr18:74119120 A/C cg24786174 chr18:74118243 ZNF516 0.86 16.2 0.71 1.71e-41 Longevity; CESC cis rs10504229 0.679 rs12675340 chr8:58035501 T/A cg24829409 chr8:58192753 C8orf71 -0.46 -5.9 -0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg00149659 chr3:10157352 C3orf10 0.75 9.12 0.49 1.96e-17 Alzheimer's disease; CESC cis rs523522 1.000 rs1563333 chr12:120934407 C/T cg12219531 chr12:120966889 COQ5 0.75 9.95 0.52 5.02e-20 High light scatter reticulocyte count; CESC cis rs6998277 0.830 rs12543008 chr8:103603747 C/T cg10187029 chr8:103597600 NA 0.74 9.75 0.51 2.16e-19 Migraine; CESC cis rs959260 1.000 rs4789186 chr17:73386086 C/T cg20590849 chr17:73267439 MIF4GD -0.57 -6.41 -0.37 6.55e-10 Systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25469252 chr19:55994021 ZNF628 0.42 6.23 0.36 1.82e-9 Fibrinogen levels; CESC trans rs561341 0.825 rs2008368 chr17:30347397 T/C cg27661571 chr11:113659931 NA -0.83 -7.34 -0.41 2.56e-12 Hip circumference adjusted for BMI; CESC cis rs7264396 0.779 rs6087723 chr20:34175783 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.6 7.1 0.4 1.15e-11 Total cholesterol levels; CESC cis rs1348850 0.567 rs12994392 chr2:178536640 A/G cg23306229 chr2:178417860 TTC30B 0.53 6.97 0.39 2.55e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg25985355 chr7:65971099 NA 0.32 5.23 0.31 3.53e-7 Aortic root size; CESC cis rs1801251 1.000 rs283475 chr2:233654381 A/C cg08000102 chr2:233561755 GIGYF2 -0.7 -10.06 -0.53 2.24e-20 Coronary artery disease; CESC trans rs57221529 0.766 rs1399381 chr5:589853 G/T cg25482853 chr8:67687455 SGK3 1.0 10.06 0.53 2.27e-20 Lung disease severity in cystic fibrosis; CESC cis rs9837602 1.000 rs7627991 chr3:99808338 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 6.83 0.39 5.64e-11 Breast cancer; CESC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.58 7.16 0.4 7.84e-12 Height; CESC cis rs9549367 0.826 rs2302755 chr13:113898418 C/T cg00898013 chr13:113819073 PROZ -0.54 -7.67 -0.43 3.27e-13 Platelet distribution width; CESC cis rs7044106 0.762 rs1530370 chr9:123424552 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.85 0.55 6.01e-23 Hip circumference adjusted for BMI; CESC cis rs9549260 0.755 rs9532571 chr13:41218670 C/T cg21288729 chr13:41239152 FOXO1 0.63 8.18 0.45 1.22e-14 Red blood cell count; CESC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg12641515 chr19:46296257 DMWD 0.73 9.8 0.52 1.5e-19 Coronary artery disease; CESC cis rs10129255 0.500 rs6576231 chr14:107191930 T/C cg23076370 chr14:107095027 NA -0.65 -9.51 -0.5 1.23e-18 Kawasaki disease; CESC trans rs66573146 0.561 rs67245546 chr4:6947164 T/C cg07817883 chr1:32538562 TMEM39B 1.35 8.85 0.48 1.24e-16 Granulocyte percentage of myeloid white cells; CESC cis rs3540 0.553 rs8042861 chr15:90977333 G/T cg22089800 chr15:90895588 ZNF774 0.64 8.92 0.48 7.76e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9309473 0.519 rs1881246 chr2:73650122 T/A cg20560298 chr2:73613845 ALMS1 0.5 7.21 0.4 5.96e-12 Metabolite levels; CESC cis rs79349575 0.783 rs56046215 chr17:47008757 A/T cg16584676 chr17:46985605 UBE2Z 0.54 6.68 0.38 1.44e-10 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19507727 chr1:233086292 C1orf57 0.65 7.1 0.4 1.15e-11 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11421459 chr7:91763989 CYP51A1 -0.53 -7.07 -0.4 1.4e-11 Asthma; CESC cis rs9488822 0.702 rs6909746 chr6:116352750 C/T cg26893134 chr6:116381904 FRK 0.25 6.03 0.35 5.41e-9 Cholesterol, total;LDL cholesterol; CESC cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg05040210 chr1:18807594 KLHDC7A -0.37 -6.75 -0.38 9.08e-11 Breast cancer; CESC cis rs62064224 0.714 rs62064225 chr17:30635429 C/T cg18200150 chr17:30822561 MYO1D 0.38 5.14 0.3 5.46e-7 Schizophrenia; CESC cis rs644799 1.000 rs617999 chr11:95589935 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.87 12.56 0.61 1.04e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs72627123 0.867 rs57685514 chr14:74487592 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.82 0.34 1.74e-8 Morning vs. evening chronotype; CESC cis rs6499255 0.951 rs76407217 chr16:69690355 A/T cg15192750 chr16:69999425 NA 0.46 5.34 0.31 2.04e-7 IgE levels; CESC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.77 -10.59 -0.55 4.53e-22 Prudent dietary pattern; CESC cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg04455712 chr21:45112962 RRP1B 0.39 5.81 0.34 1.78e-8 Mean corpuscular volume; CESC cis rs654950 0.776 rs2759254 chr1:42035683 G/C cg06885757 chr1:42089581 HIVEP3 -0.63 -9.95 -0.52 5.21e-20 Airway imaging phenotypes; CESC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.88 -0.59 2.2e-26 Alzheimer's disease; CESC cis rs9914988 0.832 rs34901720 chr17:27179518 A/G cg20469991 chr17:27169893 C17orf63 -0.43 -5.14 -0.3 5.43e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs2777491 0.872 rs7163649 chr15:41586798 A/G cg18705301 chr15:41695430 NDUFAF1 -0.6 -9.07 -0.49 2.7e-17 Ulcerative colitis; CESC cis rs9811920 0.732 rs793446 chr3:99578114 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -5.05 -0.3 8.14e-7 Axial length; CESC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.1 -0.3 6.4e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs72634258 0.554 rs13306061 chr1:7913445 C/T cg00042356 chr1:8021962 PARK7 0.57 5.51 0.32 8.3e-8 Inflammatory bowel disease; CESC cis rs8092503 1.000 rs1965662 chr18:52486080 C/T cg12377874 chr18:52495404 RAB27B 0.39 6.39 0.37 7.28e-10 Childhood body mass index; CESC cis rs2735413 0.918 rs11150037 chr16:78075774 A/G cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26731060 chr17:27229515 DHRS13 -0.49 -6.45 -0.37 5.16e-10 Ulcerative colitis; CESC cis rs250677 0.522 rs12523526 chr5:148349107 A/C cg18129178 chr5:148520854 ABLIM3 0.47 5.04 0.3 8.62e-7 Breast cancer; CESC cis rs3820068 0.581 rs16849152 chr1:15921774 A/C cg13390004 chr1:15929781 NA 0.34 5.36 0.31 1.85e-7 Systolic blood pressure; CESC cis rs6088580 0.634 rs6059875 chr20:33086090 T/G cg24642439 chr20:33292090 TP53INP2 0.5 6.55 0.37 3.05e-10 Glomerular filtration rate (creatinine); CESC cis rs7267979 1.000 rs4815417 chr20:25379526 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -17.84 -0.74 2.73e-47 Liver enzyme levels (alkaline phosphatase); CESC trans rs629535 0.773 rs686683 chr8:70070364 G/A cg21567404 chr3:27674614 NA 0.88 10.34 0.54 2.74e-21 Dupuytren's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15060598 chr10:65186990 JMJD1C 0.49 6.44 0.37 5.68e-10 Fibrinogen levels; CESC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg10351095 chr21:47802916 PCNT -0.43 -5.58 -0.32 5.84e-8 Testicular germ cell tumor; CESC cis rs708547 0.647 rs1626594 chr4:57878254 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -5.58 -0.32 6.06e-8 Response to bleomycin (chromatid breaks); CESC cis rs4891159 0.790 rs56077581 chr18:74116865 T/G cg24786174 chr18:74118243 ZNF516 -0.74 -11.59 -0.58 2.15e-25 Longevity; CESC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg08888203 chr3:10149979 C3orf24 0.48 6.0 0.35 6.3e-9 Alzheimer's disease; CESC cis rs225245 0.755 rs6505493 chr17:34028901 A/G cg05299278 chr17:33885742 SLFN14 0.39 5.55 0.32 7.07e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05291119 chr3:75484440 FAM86D -0.63 -7.17 -0.4 7.41e-12 Gut microbiome composition (summer); CESC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg04553112 chr3:125709451 NA -0.55 -5.82 -0.34 1.71e-8 Blood pressure (smoking interaction); CESC cis rs3540 0.597 rs4620932 chr15:91036569 G/A cg22089800 chr15:90895588 ZNF774 0.61 8.14 0.45 1.57e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg18446336 chr7:2847575 GNA12 -0.38 -5.75 -0.33 2.44e-8 Height; CESC cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg10523679 chr1:76189770 ACADM 0.69 6.69 0.38 1.32e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1055129 0.560 rs3682 chr17:73942150 A/G cg08125733 chr17:73851984 WBP2 0.47 6.38 0.37 7.65e-10 White matter hyperintensity burden; CESC cis rs6460942 1.000 rs73053527 chr7:12313008 C/A cg20607287 chr7:12443886 VWDE -0.79 -8.51 -0.46 1.32e-15 Coronary artery disease; CESC cis rs12142240 0.698 rs17361915 chr1:46847321 C/T cg10495392 chr1:46806563 NSUN4 0.56 6.15 0.35 2.86e-9 Menopause (age at onset); CESC cis rs654950 0.743 rs115951861 chr1:41992488 C/T cg06885757 chr1:42089581 HIVEP3 -0.44 -6.75 -0.38 9.38e-11 Airway imaging phenotypes; CESC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg23590916 chr17:43697445 MGC57346 0.66 6.72 0.38 1.09e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6456156 0.586 rs7742305 chr6:167485723 C/T cg23791538 chr6:167370224 RNASET2 -0.5 -6.37 -0.36 8.51e-10 Primary biliary cholangitis; CESC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17253792 0.822 rs13379342 chr14:56050452 A/G cg01858014 chr14:56050164 KTN1 -0.95 -7.37 -0.41 2.23e-12 Putamen volume; CESC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg12463550 chr7:65579703 CRCP 0.56 7.13 0.4 9.77e-12 Aortic root size; CESC trans rs3808502 0.549 rs11991139 chr8:11428395 C/T cg15556689 chr8:8085844 FLJ10661 -0.63 -7.51 -0.42 9.29e-13 Neuroticism; CESC trans rs1850744 0.510 rs10003673 chr4:9862300 G/A cg06372015 chr11:43602000 MIR129-2 0.59 6.0 0.35 6.4e-9 Economic and political preferences; CESC cis rs796364 0.806 rs188102 chr2:200903189 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.83 -7.71 -0.43 2.49e-13 Schizophrenia; CESC cis rs854765 0.547 rs2955372 chr17:17970229 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.86 -0.48 1.18e-16 Total body bone mineral density; CESC cis rs870825 0.616 rs2141258 chr4:185609576 A/C cg04058563 chr4:185651563 MLF1IP -0.59 -6.18 -0.36 2.36e-9 Blood protein levels; CESC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg05564831 chr3:52568323 NT5DC2 0.45 6.48 0.37 4.36e-10 Bipolar disorder; CESC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.15e-9 Aortic root size; CESC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3820928 0.874 rs1320407 chr2:227867385 G/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.28 -0.31 2.66e-7 Pulmonary function; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg22482658 chr9:111624589 ACTL7A 0.43 6.3 0.36 1.23e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14611774 chr19:9929570 FBXL12 0.55 6.2 0.36 2.18e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02184338 chr7:101331866 NA 0.62 7.17 0.4 7.69e-12 Gut microbiome composition (summer); CESC cis rs10885582 0.781 rs11196783 chr10:116304133 T/A cg17056676 chr10:116301354 ABLIM1 -0.29 -5.22 -0.31 3.6e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23466916 chr2:192543328 OBFC2A -0.56 -6.53 -0.37 3.34e-10 Gut microbiome composition (summer); CESC cis rs4566357 0.615 rs3769642 chr2:227917323 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.15 -0.4 8.33e-12 Coronary artery disease; CESC cis rs698833 0.859 rs17580340 chr2:44602554 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.76 0.33 2.3e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7264396 0.635 rs6060673 chr20:34482396 C/T cg23207816 chr20:34252616 CPNE1;RBM12 -0.54 -6.44 -0.37 5.44e-10 Total cholesterol levels; CESC cis rs16857609 0.564 rs13406698 chr2:218283085 A/G cg15335768 chr2:218268053 DIRC3 -0.39 -5.41 -0.32 1.42e-7 Breast cancer;Breast cancer (estrogen-receptor negative); CESC cis rs1506636 0.854 rs6466879 chr7:123276197 G/A cg03229431 chr7:123269106 ASB15 -0.52 -6.85 -0.39 5.16e-11 Plateletcrit;Platelet count; CESC cis rs4722166 0.630 rs10950916 chr7:22799667 C/T cg13104385 chr7:22767384 IL6 0.46 5.84 0.34 1.54e-8 Lung cancer; CESC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg19717773 chr7:2847554 GNA12 -0.45 -6.56 -0.37 2.79e-10 Height; CESC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs868036 1.000 rs4325504 chr15:68055570 A/G cg08079166 chr15:68083412 MAP2K5 -0.42 -6.51 -0.37 3.67e-10 Restless legs syndrome; CESC cis rs3749237 0.595 rs11130192 chr3:49467206 C/G cg07636037 chr3:49044803 WDR6 0.6 8.73 0.47 2.98e-16 Resting heart rate; CESC cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg20476274 chr7:133979776 SLC35B4 0.67 9.97 0.52 4.46e-20 Mean platelet volume; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg16014989 chr1:156023859 ROBLD3;UBQLN4 0.48 6.03 0.35 5.42e-9 Myopia (pathological); CESC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg00409905 chr10:38381863 ZNF37A -0.52 -7.03 -0.4 1.8e-11 Extrinsic epigenetic age acceleration; CESC trans rs561341 1.000 rs72823789 chr17:30284084 G/A cg20587970 chr11:113659929 NA -1.48 -19.48 -0.77 4.55e-53 Hip circumference adjusted for BMI; CESC cis rs2295499 0.610 rs12502642 chr4:2714023 T/C cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.32 -0.31 2.17e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09952564 chr10:5979174 FBXO18 -0.58 -6.52 -0.37 3.5e-10 Gut microbiome composition (summer); CESC trans rs7307889 0.793 rs56201315 chr12:6013379 G/C cg18407955 chr7:158110685 PTPRN2 -0.78 -6.69 -0.38 1.34e-10 Obesity-related traits; CESC cis rs17253792 0.822 rs45501402 chr14:56140115 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25282353 chr6:144416767 SF3B5 0.56 6.29 0.36 1.28e-9 Gut microbiome composition (summer); CESC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg02038168 chr22:39784481 NA -0.61 -7.88 -0.44 8.31e-14 Intelligence (multi-trait analysis); CESC trans rs61869271 0.805 rs7086663 chr10:116766336 A/T cg17463145 chr7:79084011 MAGI2 0.31 6.08 0.35 4.1e-9 Tonsillectomy; CESC cis rs763121 0.813 rs2179143 chr22:39037984 A/G cg06022373 chr22:39101656 GTPBP1 0.81 13.07 0.63 1.76e-30 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21069814 chr3:47891476 DHX30 0.44 6.15 0.35 2.78e-9 Fibrinogen levels; CESC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.32 0.31 2.17e-7 Bipolar disorder; CESC cis rs7818345 1.000 rs4392916 chr8:19309355 T/C cg11303988 chr8:19266685 CSGALNACT1 0.35 6.18 0.35 2.39e-9 Language performance in older adults (adjusted for episodic memory); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24995798 chr10:25305002 ENKUR;THNSL1 -0.49 -6.29 -0.36 1.33e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg27170947 chr2:26402098 FAM59B -0.83 -9.92 -0.52 6.22e-20 Gut microbiome composition (summer); CESC cis rs6460942 0.545 rs17448114 chr7:12524458 G/C cg06484146 chr7:12443880 VWDE -0.71 -7.69 -0.43 2.88e-13 Coronary artery disease; CESC cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 4.04e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg05283184 chr6:79620031 NA -0.44 -6.76 -0.38 8.65e-11 Intelligence (multi-trait analysis); CESC cis rs3733585 0.673 rs4459990 chr4:9954005 T/C cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg13628971 chr7:2884303 GNA12 0.67 8.58 0.47 7.89e-16 Height; CESC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.5 -5.36 -0.31 1.82e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs911555 0.755 rs8014013 chr14:103937372 A/G cg24130564 chr14:104152367 KLC1 0.52 6.68 0.38 1.38e-10 Intelligence (multi-trait analysis); CESC cis rs9487051 0.676 rs13210693 chr6:109598964 A/G cg12927641 chr6:109611667 NA 0.35 5.18 0.3 4.44e-7 Reticulocyte fraction of red cells; CESC cis rs2439831 0.850 rs28578398 chr15:44075046 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.7 6.72 0.38 1.14e-10 Lung cancer in ever smokers; CESC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg11764359 chr7:65958608 NA -0.72 -9.55 -0.51 9e-19 Aortic root size; CESC cis rs4889855 0.505 rs12952775 chr17:78607820 A/G cg16591659 chr17:78472290 NA -0.34 -5.49 -0.32 9.53e-8 Fractional excretion of uric acid; CESC cis rs1538970 1.000 rs4520450 chr1:45834773 A/G cg03146154 chr1:46216737 IPP 0.46 5.51 0.32 8.63e-8 Platelet count; CESC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg26343298 chr8:95960752 TP53INP1 0.36 5.98 0.34 7.06e-9 Type 2 diabetes; CESC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg16545954 chr1:2118288 C1orf86 -0.32 -5.8 -0.34 1.89e-8 Height; CESC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.42 0.32 1.35e-7 Major depressive disorder; CESC trans rs1814175 0.586 rs2866862 chr11:49954588 T/C cg15704280 chr7:45808275 SEPT13 -0.98 -18.56 -0.75 7.41e-50 Height; CESC cis rs193541 0.593 rs30042 chr5:122272641 A/G cg19412675 chr5:122181750 SNX24 0.43 5.19 0.3 4.13e-7 Glucose homeostasis traits; CESC trans rs35110281 0.782 rs2246602 chr21:45064296 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 7.17 0.4 7.43e-12 Mean corpuscular volume; CESC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg14664628 chr15:75095509 CSK -0.54 -7.17 -0.4 7.28e-12 Breast cancer; CESC cis rs2243480 0.803 rs34804747 chr7:65412942 G/C cg13147721 chr7:65941812 NA -0.83 -7.97 -0.44 4.85e-14 Diabetic kidney disease; CESC cis rs9435341 0.731 rs4914939 chr1:107558361 A/T cg09367891 chr1:107599246 PRMT6 0.65 7.79 0.43 1.56e-13 Facial morphology (factor 21, depth of nasal alae); CESC cis rs634534 0.591 rs688862 chr11:65733393 A/G cg26695010 chr11:65641043 EFEMP2 -0.4 -5.09 -0.3 6.72e-7 Sum eosinophil basophil counts;Eosinophil counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12384262 chr21:45744725 PFKL -0.48 -6.0 -0.35 6.54e-9 Gut microbiome composition (summer); CESC cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg16278512 chr7:12443529 VWDE -0.5 -5.08 -0.3 7.3e-7 Coronary artery disease; CESC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg18230493 chr5:56204884 C5orf35 0.61 8.09 0.44 2.17e-14 Initial pursuit acceleration; CESC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg07308232 chr7:1071921 C7orf50 -0.41 -5.61 -0.33 5.19e-8 Longevity;Endometriosis; CESC cis rs258892 0.895 rs10077575 chr5:72084557 A/C cg21869765 chr5:72125136 TNPO1 -0.43 -5.51 -0.32 8.4e-8 Small cell lung carcinoma; CESC cis rs3820068 0.581 rs67806552 chr1:15927138 T/C cg16988262 chr1:15930761 NA 0.33 5.35 0.31 1.89e-7 Systolic blood pressure; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg22614265 chr7:100425456 EPHB4 0.49 6.4 0.37 6.9e-10 Systemic lupus erythematosus; CESC trans rs7178375 1.000 rs11070678 chr15:31219764 A/G cg04373760 chr16:53404718 NA 0.54 7.07 0.4 1.34e-11 Hypertriglyceridemia; CESC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.89 0.52 7.53e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8062405 1.000 rs62036657 chr16:28844365 G/A cg08761264 chr16:28874980 SH2B1 -0.46 -5.72 -0.33 2.9e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg14393609 chr7:65229607 NA 0.51 7.0 0.39 2.14e-11 Calcium levels; CESC cis rs4764487 0.735 rs2072372 chr12:6344600 C/A cg08284733 chr12:6341482 CD9 0.41 5.95 0.34 8.44e-9 Mean platelet volume; CESC cis rs11608355 0.545 rs7969313 chr12:109907303 A/G cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02262786 chr10:103816019 C10orf76 0.53 7.42 0.41 1.57e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs6460942 1.000 rs75564554 chr7:12319362 A/C cg20607287 chr7:12443886 VWDE -0.79 -8.51 -0.46 1.32e-15 Coronary artery disease; CESC cis rs7193541 0.662 rs8058133 chr16:74657485 A/T cg01733217 chr16:74700730 RFWD3 1.07 20.8 0.79 1.26e-57 Multiple myeloma; CESC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg16325326 chr1:53192061 ZYG11B 0.82 12.7 0.62 3.43e-29 Monocyte count; CESC cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.63 0.33 4.68e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs146671954 1 rs146671954 chr9:136934203 G/A cg10765909 chr12:53715428 AAAS -0.72 -6.48 -0.37 4.43e-10 Red cell distribution width; CESC cis rs79387448 0.638 rs74731686 chr2:103043981 G/A cg09003973 chr2:102972529 NA 0.94 7.74 0.43 2.04e-13 Gut microbiota (bacterial taxa); CESC cis rs2732480 0.538 rs2732462 chr12:48696384 A/G cg04545296 chr12:48745243 ZNF641 0.41 6.88 0.39 4.32e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs1348850 0.793 rs12990917 chr2:178487259 T/G cg22681709 chr2:178499509 PDE11A -0.48 -7.47 -0.42 1.17e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7474896 0.583 rs10764144 chr10:37975732 G/C cg25427524 chr10:38739819 LOC399744 -0.45 -5.24 -0.31 3.29e-7 Obesity (extreme); CESC cis rs1879734 0.648 rs7554633 chr1:54163128 A/G cg23596471 chr1:54105337 GLIS1 0.33 5.41 0.32 1.38e-7 Mitral valve prolapse; CESC cis rs763121 0.853 rs2072796 chr22:39064230 A/G cg06022373 chr22:39101656 GTPBP1 0.88 13.95 0.65 1.51e-33 Menopause (age at onset); CESC cis rs17253792 0.822 rs8018142 chr14:56173288 C/T cg01858014 chr14:56050164 KTN1 -0.6 -5.51 -0.32 8.7e-8 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07496882 chr10:112631570 LOC282997;PDCD4 0.58 6.88 0.39 4.33e-11 Gut microbiome composition (summer); CESC cis rs6032067 0.777 rs13039211 chr20:43784396 C/T cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs6598955 0.614 rs1134584 chr1:26608828 G/A cg04990556 chr1:26633338 UBXN11 -0.77 -10.97 -0.56 2.48e-23 Obesity-related traits; CESC cis rs9911578 0.741 rs2611776 chr17:56819636 G/T cg05425664 chr17:57184151 TRIM37 -0.49 -6.72 -0.38 1.11e-10 Intelligence (multi-trait analysis); CESC cis rs2070729 0.523 rs743562 chr5:131872383 C/T cg00255919 chr5:131827918 IRF1 -0.31 -5.14 -0.3 5.22e-7 Platelet count; CESC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg27266027 chr21:40555129 PSMG1 0.48 5.91 0.34 1.06e-8 Cognitive function; CESC cis rs2644899 0.859 rs2604893 chr19:41293543 A/G cg10585486 chr19:41304133 EGLN2 -0.35 -5.05 -0.3 8.07e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs10242455 0.867 rs2257401 chr7:99306685 C/G cg07715041 chr7:99302981 CYP3A7 -0.41 -5.21 -0.3 3.78e-7 Blood metabolite levels; CESC cis rs12200560 0.505 rs211176 chr6:97073821 G/A cg06623918 chr6:96969491 KIAA0776 0.52 6.65 0.38 1.71e-10 Coronary heart disease; CESC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg07395648 chr5:131743802 NA 0.42 5.5 0.32 9.14e-8 Breast cancer; CESC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg25204440 chr1:209979598 IRF6 0.66 8.35 0.46 3.91e-15 Cleft lip with or without cleft palate; CESC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 10.09 0.53 1.8e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10440939 chr17:27493798 MYO18A -0.64 -7.22 -0.41 5.52e-12 Gut microbiome composition (summer); CESC cis rs7592578 0.771 rs62181034 chr2:191354963 C/A cg27211696 chr2:191398769 TMEM194B -0.58 -5.25 -0.31 3.09e-7 Diastolic blood pressure; CESC cis rs208520 0.690 rs12202913 chr6:66734198 C/T cg07460842 chr6:66804631 NA 0.96 12.8 0.62 1.54e-29 Exhaled nitric oxide output; CESC cis rs11577318 0.796 rs4625269 chr1:26626967 C/A cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.46 -0.37 5.05e-10 Granulocyte percentage of myeloid white cells; CESC cis rs2236918 0.710 rs2526702 chr1:242017983 G/A cg17736920 chr1:242011382 EXO1 0.57 7.39 0.41 1.93e-12 Menopause (age at onset); CESC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.89 0.39 4.08e-11 Bipolar disorder; CESC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg12463550 chr7:65579703 CRCP 0.49 6.26 0.36 1.53e-9 Aortic root size; CESC cis rs7762018 0.891 rs3088346 chr6:170149793 T/C cg05834625 chr6:170176447 C6orf70 0.64 6.98 0.39 2.35e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs10744422 1.000 rs1532835 chr12:123330665 G/A cg25930673 chr12:123319894 HIP1R -0.72 -5.73 -0.33 2.79e-8 Schizophrenia; CESC cis rs2304069 0.550 rs216144 chr5:149445480 T/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.7 8.46 0.46 1.79e-15 HIV-1 control; CESC cis rs9640161 0.789 rs2098053 chr7:150043205 G/A cg13722127 chr7:150037890 RARRES2 0.38 5.08 0.3 7.09e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06976634 chr11:886709 CHID1 0.45 6.2 0.36 2.11e-9 Fibrinogen levels; CESC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg10053473 chr17:62856997 LRRC37A3 -0.66 -9.2 -0.49 1.09e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4523957 0.583 rs2760745 chr17:2035591 T/C cg16513277 chr17:2031491 SMG6 -0.79 -11.73 -0.58 6.95e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg11211951 chr8:145729740 GPT -0.43 -7.1 -0.4 1.15e-11 Age at first birth; CESC cis rs765787 0.530 rs4238376 chr15:45541887 T/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs1669338 0.588 rs62228620 chr3:3184913 C/T cg16797762 chr3:3221439 CRBN -0.61 -6.59 -0.38 2.43e-10 White matter integrity; CESC cis rs7520050 0.966 rs4134386 chr1:46395089 G/A cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.66e-9 Red blood cell count;Reticulocyte count; CESC cis rs11155671 0.530 rs9383940 chr6:150226059 T/G cg09699651 chr6:150184138 LRP11 0.43 5.75 0.33 2.43e-8 Testicular germ cell tumor; CESC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg22143856 chr6:28129313 ZNF389 0.42 5.25 0.31 3.16e-7 Parkinson's disease; CESC cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg21573476 chr21:45109991 RRP1B -0.43 -6.09 -0.35 3.88e-9 Mean corpuscular volume; CESC cis rs477692 1.000 rs4750759 chr10:131436603 G/A cg05714579 chr10:131428358 MGMT -0.47 -6.28 -0.36 1.35e-9 Response to temozolomide; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg05215748 chr17:6898738 ALOX12 0.33 6.86 0.39 4.71e-11 Tonsillectomy; CESC cis rs2243480 1.000 rs1404147 chr7:65264524 C/T cg13147721 chr7:65941812 NA -0.84 -8.4 -0.46 2.8e-15 Diabetic kidney disease; CESC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg20811857 chr17:78079795 GAA 0.43 6.11 0.35 3.47e-9 Yeast infection; CESC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg21770322 chr7:97807741 LMTK2 0.57 8.75 0.47 2.56e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg14403583 chr14:105418241 AHNAK2 -0.57 -7.86 -0.44 9.41e-14 Rheumatoid arthritis; CESC cis rs11683229 0.632 rs2302567 chr2:63170921 C/G cg17519650 chr2:63277830 OTX1 -0.65 -5.19 -0.3 4.19e-7 Protein quantitative trait loci; CESC cis rs7772486 0.790 rs2243665 chr6:146208120 A/C cg23711669 chr6:146136114 FBXO30 0.87 11.34 0.57 1.45e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs2243480 1.000 rs73142166 chr7:65375832 A/G cg18252515 chr7:66147081 NA -1.23 -11.37 -0.57 1.14e-24 Diabetic kidney disease; CESC cis rs10883723 0.810 rs7093028 chr10:104259417 A/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs6598955 0.670 rs12733645 chr1:26540356 G/T cg00852783 chr1:26633632 UBXN11 0.4 5.81 0.34 1.79e-8 Obesity-related traits; CESC cis rs7605827 0.930 rs7586201 chr2:15575735 G/A cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC cis rs965469 1.000 rs1040726 chr20:3264267 C/T cg25506879 chr20:3388711 C20orf194 -0.55 -5.98 -0.35 7.01e-9 IFN-related cytopenia; CESC cis rs11792861 0.855 rs72607165 chr9:111814498 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 5.62 0.33 4.83e-8 Menarche (age at onset); CESC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg06456125 chr7:65229604 NA -0.48 -6.24 -0.36 1.76e-9 Aortic root size; CESC cis rs904092 0.720 rs1229970 chr4:100204380 A/C cg12011299 chr4:100065546 ADH4 -0.56 -6.34 -0.36 9.78e-10 Alcohol dependence; CESC cis rs9768139 0.708 rs10233815 chr7:158114348 C/T cg25566285 chr7:158114605 PTPRN2 0.54 9.09 0.49 2.33e-17 Calcium levels; CESC cis rs6951245 0.507 rs10227709 chr7:1180515 T/G cg18402987 chr7:1209562 NA 0.5 6.03 0.35 5.6e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10870270 0.957 rs9971084 chr10:133788747 G/C cg08754478 chr10:133766260 PPP2R2D -0.58 -7.49 -0.42 1.01e-12 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2011503 0.597 rs8103992 chr19:19665643 A/C cg11584989 chr19:19387371 SF4 -0.47 -5.43 -0.32 1.28e-7 Bipolar disorder; CESC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg18876405 chr7:65276391 NA 0.54 7.28 0.41 3.88e-12 Aortic root size; CESC cis rs372883 0.600 rs2832293 chr21:30738872 C/G cg08807101 chr21:30365312 RNF160 0.45 5.22 0.31 3.55e-7 Pancreatic cancer; CESC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg19774624 chr17:42201019 HDAC5 -0.88 -14.32 -0.66 7.95e-35 Total body bone mineral density; CESC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg19717773 chr7:2847554 GNA12 -0.48 -6.61 -0.38 2.14e-10 Height; CESC cis rs4654899 0.965 rs10753513 chr1:21492168 T/C cg05370193 chr1:21551575 ECE1 -0.39 -5.77 -0.33 2.19e-8 Superior frontal gyrus grey matter volume; CESC cis rs4268898 0.662 rs2891380 chr2:24525830 G/A cg20701182 chr2:24300061 SF3B14 0.63 6.88 0.39 4.25e-11 Asthma; CESC cis rs1018836 0.663 rs12674903 chr8:91475774 T/C cg16814680 chr8:91681699 NA -0.55 -7.29 -0.41 3.5e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.63 0.38 1.9e-10 Prudent dietary pattern; CESC cis rs6545977 0.531 rs2539982 chr2:63111004 G/A cg17519650 chr2:63277830 OTX1 0.61 8.51 0.46 1.28e-15 Prostate cancer; CESC cis rs9911578 0.692 rs412000 chr17:56709058 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.41 5.44 0.32 1.21e-7 Intelligence (multi-trait analysis); CESC trans rs3942852 0.806 rs10734562 chr11:48128189 A/T cg15704280 chr7:45808275 SEPT13 0.6 6.85 0.39 5.01e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs7772486 0.806 rs4075695 chr6:146250959 A/G cg05347473 chr6:146136440 FBXO30 -0.48 -6.42 -0.37 6.21e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2204008 0.537 rs28680519 chr12:38502946 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.51 0.54 8.26e-22 Bladder cancer; CESC cis rs77106637 0.932 rs7109082 chr11:72707441 A/C cg03713592 chr11:72463424 ARAP1 1.09 10.08 0.53 1.94e-20 Type 2 diabetes; CESC cis rs10791097 0.694 rs4457753 chr11:130755575 A/G cg09137382 chr11:130731461 NA 0.36 5.35 0.31 1.92e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs13223928 0.621 rs4722440 chr7:3155901 C/T cg19214707 chr7:3157722 NA 0.4 5.55 0.32 6.94e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs916888 0.773 rs538628 chr17:44787313 G/C cg15921436 chr17:44337874 NA 0.76 8.15 0.45 1.47e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3126085 0.935 rs11204937 chr1:152193851 C/T cg03465714 chr1:152285911 FLG -0.41 -5.05 -0.3 8.35e-7 Atopic dermatitis; CESC cis rs4077515 0.839 rs10781518 chr9:139300547 C/T cg14169450 chr9:139327907 INPP5E -0.41 -5.23 -0.31 3.48e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26172013 chr20:32031452 SNTA1 -0.42 -5.28 -0.31 2.68e-7 Ulcerative colitis; CESC cis rs12765878 0.967 rs7920217 chr10:105668172 C/T cg24587175 chr10:105670608 OBFC1 0.32 5.29 0.31 2.63e-7 Coronary artery disease; CESC cis rs1879734 0.636 rs17109200 chr1:54175548 A/G cg23596471 chr1:54105337 GLIS1 0.29 5.1 0.3 6.5e-7 Mitral valve prolapse; CESC cis rs12701220 0.894 rs10263252 chr7:1049949 G/A cg20821713 chr7:1055600 C7orf50 -0.51 -5.35 -0.31 1.89e-7 Bronchopulmonary dysplasia; CESC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs6835098 1.000 rs4695826 chr4:174089426 T/G cg08422745 chr4:174089978 GALNT7 -0.82 -12.01 -0.59 7.93e-27 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs2455799 0.613 rs10510443 chr3:15829127 A/G cg16303742 chr3:15540471 COLQ -0.39 -6.02 -0.35 5.68e-9 Mean platelet volume; CESC cis rs10206020 0.885 rs6720797 chr2:1574340 T/C cg12573674 chr2:1569213 NA -0.46 -5.2 -0.3 3.96e-7 IgG glycosylation; CESC cis rs7680126 0.596 rs4637402 chr4:10045430 C/T cg02734326 chr4:10020555 SLC2A9 0.48 5.29 0.31 2.63e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg14893161 chr1:205819251 PM20D1 0.94 17.62 0.73 1.56e-46 Menarche (age at onset); CESC trans rs6759922 1.000 rs4330131 chr2:22445880 G/A cg21162304 chr4:80247171 NAA11 0.38 6.24 0.36 1.72e-9 Subjective well-being (multi-trait analysis); CESC cis rs3733585 0.648 rs13103497 chr4:9979262 A/G cg11266682 chr4:10021025 SLC2A9 0.55 9.92 0.52 6.09e-20 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4835473 0.932 rs36018946 chr4:144902095 G/T cg25736465 chr4:144833511 NA -0.43 -6.59 -0.38 2.36e-10 Immature fraction of reticulocytes; CESC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg07256732 chr16:621771 PIGQ -0.34 -5.88 -0.34 1.21e-8 Height; CESC cis rs11958404 0.546 rs7727054 chr5:157442692 G/A cg05962755 chr5:157440814 NA 0.38 5.5 0.32 8.89e-8 IgG glycosylation; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg14182682 chr14:57857589 NAA30 -0.46 -6.07 -0.35 4.3e-9 Thyroid stimulating hormone; CESC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg07167872 chr1:205819463 PM20D1 0.76 12.94 0.62 5.37e-30 Menarche (age at onset); CESC cis rs61931739 0.817 rs1705772 chr12:34174756 G/A cg19457237 chr12:34500585 NA -0.4 -5.57 -0.32 6.13e-8 Morning vs. evening chronotype; CESC cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg09021430 chr5:549028 NA -0.43 -5.41 -0.32 1.43e-7 Lung disease severity in cystic fibrosis; CESC cis rs10256972 0.869 rs13236369 chr7:1033799 G/T cg04025307 chr7:1156635 C7orf50 0.38 6.08 0.35 4.12e-9 Longevity;Endometriosis; CESC cis rs2933343 1.000 rs1683782 chr3:128640277 A/G cg25356066 chr3:128598488 ACAD9 0.61 7.52 0.42 8.33e-13 IgG glycosylation; CESC cis rs6942756 1.000 rs17168512 chr7:128955033 A/G cg02491457 chr7:128862824 NA -0.69 -9.36 -0.5 3.61e-18 White matter hyperintensity burden; CESC cis rs7216064 1.000 rs12452511 chr17:65832576 A/G cg07042672 chr17:66097459 LOC651250 -0.53 -5.5 -0.32 8.85e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4722166 0.630 rs13311199 chr7:22789793 A/C cg05472934 chr7:22766657 IL6 0.83 10.33 0.54 3.1e-21 Lung cancer; CESC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg11890956 chr21:40555474 PSMG1 -0.9 -14.19 -0.66 2.18e-34 Cognitive function; CESC cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.46 0.32 1.09e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3780486 0.846 rs73484568 chr9:33132492 G/A cg13443165 chr9:33130375 B4GALT1 0.43 6.26 0.36 1.55e-9 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26440361 chr12:122064389 ORAI1 0.56 6.03 0.35 5.39e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg06634786 chr22:41940651 POLR3H -0.69 -7.05 -0.4 1.59e-11 Vitiligo; CESC cis rs9911578 1.000 rs2531734 chr17:56550804 T/C cg05425664 chr17:57184151 TRIM37 0.5 6.94 0.39 2.97e-11 Intelligence (multi-trait analysis); CESC cis rs3015497 0.646 rs2172673 chr14:51115807 A/G cg26011998 chr14:51135199 SAV1 -0.56 -6.27 -0.36 1.45e-9 Mean platelet volume; CESC cis rs9467711 0.606 rs9358932 chr6:26362705 A/G cg12826209 chr6:26865740 GUSBL1 -0.58 -5.04 -0.3 8.79e-7 Autism spectrum disorder or schizophrenia; CESC cis rs13333054 1.000 rs12232384 chr16:86009760 A/C cg08215318 chr16:86016387 NA -0.49 -6.04 -0.35 5.25e-9 Multiple sclerosis; CESC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.14 -0.3 5.22e-7 Lung cancer; CESC cis rs13256369 0.851 rs13266562 chr8:8564065 T/C cg17143192 chr8:8559678 CLDN23 0.78 8.81 0.48 1.63e-16 Obesity-related traits; CESC cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 12.8 0.62 1.52e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6456156 0.846 rs7774396 chr6:167519786 G/A cg07741184 chr6:167504864 NA 0.37 6.54 0.37 3.07e-10 Primary biliary cholangitis; CESC cis rs6693567 0.545 rs1313568 chr1:150344180 C/G cg09579323 chr1:150459698 TARS2 0.47 6.05 0.35 4.99e-9 Migraine; CESC cis rs7512552 0.809 rs2794685 chr1:150312268 C/T cg15654264 chr1:150340011 RPRD2 0.39 5.12 0.3 5.94e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs11792861 0.926 rs17628095 chr9:111889172 A/G cg13535736 chr9:111863775 C9orf5 0.49 6.39 0.37 7.35e-10 Menarche (age at onset); CESC cis rs2274273 0.638 rs67416413 chr14:55702263 A/G cg04306507 chr14:55594613 LGALS3 0.31 5.2 0.3 3.97e-7 Protein biomarker; CESC cis rs17253792 0.822 rs78826571 chr14:56048906 G/A cg01858014 chr14:56050164 KTN1 -0.99 -7.44 -0.42 1.43e-12 Putamen volume; CESC cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 9.16 0.49 1.46e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg24110177 chr3:50126178 RBM5 -0.55 -7.45 -0.42 1.3e-12 Body mass index; CESC cis rs12220238 1.000 rs12359456 chr10:75937994 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.57 5.11 0.3 6.25e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs9768139 0.627 rs57920447 chr7:158121243 A/G cg24154853 chr7:158122151 PTPRN2 0.4 6.25 0.36 1.66e-9 Calcium levels; CESC cis rs10851478 0.872 rs925104 chr15:49916655 T/G cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.2 0.3 3.95e-7 Oral cavity cancer; CESC trans rs7618501 0.635 rs7635002 chr3:49989155 T/G cg21659725 chr3:3221576 CRBN 0.55 7.6 0.42 5.29e-13 Intelligence (multi-trait analysis); CESC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg05340658 chr4:99064831 C4orf37 0.64 8.35 0.46 3.77e-15 Colonoscopy-negative controls vs population controls; CESC cis rs734999 0.566 rs4648563 chr1:2536002 C/G cg18854424 chr1:2615690 NA 0.27 5.24 0.31 3.32e-7 Ulcerative colitis; CESC cis rs10791097 0.667 rs1893019 chr11:130756664 C/G cg12179176 chr11:130786555 SNX19 0.67 10.54 0.54 6.34e-22 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9611565 0.694 rs2142505 chr22:41820541 A/G cg17376030 chr22:41985996 PMM1 -0.75 -7.86 -0.43 9.43e-14 Vitiligo; CESC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg00166722 chr3:10149974 C3orf24 0.5 6.59 0.38 2.37e-10 Alzheimer's disease; CESC cis rs7927771 0.524 rs3816605 chr11:47857253 T/C cg18512352 chr11:47633146 NA 0.35 5.39 0.31 1.53e-7 Subjective well-being; CESC cis rs8027181 0.839 rs2277598 chr15:73027478 T/C cg25632853 chr15:73088954 NA 0.3 5.25 0.31 3.06e-7 Triglyceride levels; CESC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg09177884 chr7:1199841 ZFAND2A -0.55 -6.22 -0.36 1.92e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs7615952 0.866 rs13063119 chr3:125643847 G/A cg07211511 chr3:129823064 LOC729375 -1.16 -16.42 -0.71 2.9e-42 Blood pressure (smoking interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23614605 chr14:35761327 PSMA6 -0.46 -6.19 -0.36 2.25e-9 Gut microbiota (bacterial taxa); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21047528 chr22:42915898 RRP7A 0.5 6.47 0.37 4.69e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6783573 0.711 rs3806701 chr3:46617337 G/A cg27371741 chr3:46619158 LRRC2;TDGF1 -0.38 -5.95 -0.34 8.42e-9 Cerebrospinal fluid biomarker levels; CESC cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9814567 0.929 rs13316205 chr3:134223563 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.73 -0.33 2.73e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg10541313 chr22:46663664 TTC38 0.68 6.0 0.35 6.32e-9 LDL cholesterol;Cholesterol, total; CESC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg06028808 chr11:68637592 NA 0.48 5.64 0.33 4.34e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4629180 0.651 rs9653468 chr2:102108403 A/G cg21388029 chr2:102003306 CREG2 0.32 5.17 0.3 4.55e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg08470875 chr2:26401718 FAM59B -0.56 -6.01 -0.35 5.98e-9 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs9848083 chr3:40466979 A/G cg24209194 chr3:40518798 ZNF619 -0.45 -6.13 -0.35 3.22e-9 Renal cell carcinoma; CESC cis rs238295 0.846 rs6053528 chr20:5582598 G/T cg24001556 chr20:5591874 RP5-1022P6.2 -0.46 -5.22 -0.31 3.64e-7 Occipital cortical area (total cortical area interaction); CESC cis rs12079745 0.793 rs3737683 chr1:169438180 A/G cg09363564 chr1:169337483 NME7;BLZF1 -1.16 -6.82 -0.39 6e-11 QT interval; CESC cis rs7582720 1.000 rs77268589 chr2:203751981 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs17345786 0.602 rs11923273 chr3:101337863 T/C cg12386194 chr3:101231763 SENP7 0.53 6.53 0.37 3.35e-10 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.753 rs28463863 chr4:98844444 T/C cg05340658 chr4:99064831 C4orf37 0.74 10.5 0.54 8.68e-22 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg12963246 chr6:28129442 ZNF389 0.57 7.81 0.43 1.31e-13 Depression; CESC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg12412775 chr1:25698385 RHCE -0.28 -5.08 -0.3 7.1e-7 Erythrocyte sedimentation rate; CESC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg04267008 chr7:1944627 MAD1L1 -0.73 -10.11 -0.53 1.58e-20 Bipolar disorder and schizophrenia; CESC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg12648201 chr2:27665141 KRTCAP3 -0.31 -5.65 -0.33 4.22e-8 Total body bone mineral density; CESC cis rs35110281 0.837 rs2838343 chr21:45078035 C/T cg21573476 chr21:45109991 RRP1B -0.5 -7.0 -0.39 2.13e-11 Mean corpuscular volume; CESC cis rs7824557 0.614 rs2293860 chr8:11219386 G/T cg21775007 chr8:11205619 TDH 0.62 9.77 0.51 1.87e-19 Retinal vascular caliber; CESC cis rs7914558 1.000 rs7077291 chr10:104945751 C/T cg04362960 chr10:104952993 NT5C2 0.46 6.16 0.35 2.74e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg04518342 chr5:131593106 PDLIM4 0.4 5.96 0.34 7.99e-9 Acylcarnitine levels; CESC cis rs12142240 0.698 rs17361887 chr1:46834775 A/G cg00530320 chr1:46809349 NSUN4 0.61 8.02 0.44 3.5e-14 Menopause (age at onset); CESC cis rs34779708 0.966 rs12775799 chr10:35488264 C/T cg04310649 chr10:35416472 CREM -0.52 -6.26 -0.36 1.54e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg11644478 chr21:40555479 PSMG1 1.05 16.66 0.72 3.85e-43 Cognitive function; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03811519 chr9:134001305 NUP214 0.44 6.17 0.35 2.55e-9 Systemic lupus erythematosus; CESC cis rs3096299 0.719 rs2965818 chr16:89510494 A/G cg00750074 chr16:89608354 SPG7 -0.39 -5.61 -0.33 5.12e-8 Multiple myeloma (IgH translocation); CESC cis rs3796352 1.000 rs2336541 chr3:52974630 G/C cg12962167 chr3:53033115 SFMBT1 0.6 5.09 0.3 6.95e-7 Immune reponse to smallpox (secreted IL-2); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15702823 chr6:10838819 NA -0.53 -6.49 -0.37 4.2e-10 Ulcerative colitis; CESC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg25036284 chr2:26402008 FAM59B -0.75 -8.46 -0.46 1.79e-15 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7216064 0.953 rs2086744 chr17:65849275 C/G cg12091567 chr17:66097778 LOC651250 -0.85 -8.69 -0.47 3.85e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03564166 chr16:70380888 DDX19A 0.63 6.93 0.39 3.26e-11 Gut microbiome composition (summer); CESC cis rs62064224 0.614 rs9916114 chr17:30766950 T/C cg18200150 chr17:30822561 MYO1D 0.4 5.16 0.3 4.76e-7 Schizophrenia; CESC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg05564831 chr3:52568323 NT5DC2 0.42 6.68 0.38 1.41e-10 Electroencephalogram traits; CESC cis rs4906332 0.899 rs12888042 chr14:103891709 G/A cg09975044 chr14:104007538 NA 0.46 6.38 0.36 7.81e-10 Coronary artery disease; CESC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg09365446 chr1:150670422 GOLPH3L 0.43 6.02 0.35 5.86e-9 Tonsillectomy; CESC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg22433210 chr17:43662623 NA -0.63 -8.08 -0.44 2.23e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs894734 0.535 rs7301643 chr12:54325796 G/T cg12374095 chr12:54320830 NA -0.42 -6.08 -0.35 4.28e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CESC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg10691866 chr7:65817282 TPST1 0.35 5.77 0.33 2.23e-8 Aortic root size; CESC cis rs8016982 0.674 rs28890880 chr14:81708031 A/G cg01989461 chr14:81687754 GTF2A1 0.66 9.76 0.51 2.07e-19 Schizophrenia; CESC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg03806693 chr22:41940476 POLR3H -1.18 -14.76 -0.67 2.13e-36 Vitiligo; CESC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg18758796 chr5:131593413 PDLIM4 0.38 5.17 0.3 4.59e-7 Breast cancer; CESC cis rs9916302 0.904 rs55660616 chr17:37684990 C/A cg00129232 chr17:37814104 STARD3 -0.56 -7.37 -0.41 2.15e-12 Glomerular filtration rate (creatinine); CESC cis rs8141529 0.732 rs5997408 chr22:29207915 G/A cg02153584 chr22:29168773 CCDC117 0.64 9.29 0.5 5.89e-18 Lymphocyte counts; CESC cis rs113835537 0.529 rs10501397 chr11:66272976 G/T cg22134325 chr11:66188745 NPAS4 0.33 5.2 0.3 3.98e-7 Airway imaging phenotypes; CESC cis rs9487051 0.676 rs6925716 chr6:109597641 T/C cg21918786 chr6:109611834 NA -0.38 -5.52 -0.32 7.88e-8 Reticulocyte fraction of red cells; CESC cis rs10791097 0.967 rs10750450 chr11:130719061 G/T cg14779329 chr11:130786720 SNX19 0.39 6.17 0.35 2.55e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6540556 0.723 rs3766618 chr1:209895437 G/T cg05527609 chr1:210001259 C1orf107 -0.78 -7.79 -0.43 1.51e-13 Red blood cell count; CESC cis rs11098499 0.863 rs1010739 chr4:120463471 C/T cg24375607 chr4:120327624 NA 0.48 5.91 0.34 1.06e-8 Corneal astigmatism; CESC cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg11752832 chr7:134001865 SLC35B4 0.54 7.02 0.4 1.88e-11 Mean platelet volume; CESC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg18252515 chr7:66147081 NA 0.4 5.25 0.31 3.16e-7 Aortic root size; CESC cis rs9811920 0.535 rs792833 chr3:99475268 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.32 5.19 0.3 4.09e-7 Axial length; CESC cis rs10911232 0.507 rs12037623 chr1:183000148 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs9462846 0.959 rs9471958 chr6:42883669 C/T cg05552183 chr6:42928497 GNMT 0.46 5.25 0.31 3.1e-7 Blood protein levels; CESC cis rs1215050 0.740 rs783963 chr4:98989070 A/G cg05340658 chr4:99064831 C4orf37 0.61 8.48 0.46 1.56e-15 Waist-to-hip ratio adjusted for body mass index; CESC trans rs6089829 0.962 rs4809455 chr20:61660781 G/C cg23505145 chr19:12996616 KLF1 0.52 6.7 0.38 1.24e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs7246657 0.943 rs9676967 chr19:37928089 G/C cg01833234 chr11:6592585 DNHD1 0.52 6.0 0.35 6.5e-9 Coronary artery calcification; CESC cis rs11822910 0.911 rs11828218 chr11:57196223 C/G cg00522883 chr11:57194120 SLC43A3 0.59 7.12 0.4 1.02e-11 Platelet distribution width; CESC cis rs4148883 0.603 rs6833176 chr4:100131163 G/C cg12011299 chr4:100065546 ADH4 -0.5 -7.2 -0.4 6.04e-12 Alcohol dependence; CESC cis rs863345 0.604 rs879637 chr1:158462697 C/T cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.53e-11 Pneumococcal bacteremia; CESC cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs854765 0.547 rs2955378 chr17:17930253 G/A cg16928487 chr17:17741425 SREBF1 -0.56 -9.54 -0.51 9.69e-19 Total body bone mineral density; CESC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg03388025 chr16:89894329 SPIRE2 0.41 8.11 0.45 1.89e-14 Vitiligo; CESC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg17372223 chr3:52568218 NT5DC2 0.42 6.47 0.37 4.6e-10 Bipolar disorder; CESC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg18404041 chr3:52824283 ITIH1 -0.4 -6.58 -0.37 2.57e-10 Bipolar disorder; CESC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg12658694 chr1:38397304 INPP5B -0.65 -8.4 -0.46 2.7e-15 Coronary artery disease; CESC cis rs1505368 0.789 rs13419353 chr2:213271459 A/T cg20637307 chr2:213403960 ERBB4 -0.37 -5.46 -0.32 1.08e-7 Symmetrical dimethylarginine levels; CESC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg02569458 chr12:86230093 RASSF9 0.51 7.69 0.43 2.85e-13 Major depressive disorder; CESC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 9.38 0.5 3.07e-18 Platelet count; CESC cis rs9911578 1.000 rs2009948 chr17:56611920 A/C cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.5e-11 Intelligence (multi-trait analysis); CESC cis rs9393692 0.620 rs9379842 chr6:26289310 C/T cg05868516 chr6:26286170 HIST1H4H -0.39 -5.5 -0.32 8.72e-8 Educational attainment; CESC cis rs7100689 0.622 rs10749569 chr10:82129892 G/A cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg03188948 chr7:1209495 NA 0.57 6.63 0.38 1.86e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7267979 0.903 rs6050481 chr20:25224580 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.6 0.69 2.21e-39 Liver enzyme levels (alkaline phosphatase); CESC cis rs748404 0.660 rs690472 chr15:43764368 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.21 0.45 9.59e-15 Lung cancer; CESC cis rs1355223 0.902 rs1258468 chr11:34729731 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.41 -0.37 6.58e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7605827 0.930 rs7580672 chr2:15586646 A/G cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC cis rs3091242 0.902 rs36003018 chr1:25784318 A/G cg02931644 chr1:25747376 RHCE -0.39 -6.54 -0.37 3.17e-10 Erythrocyte sedimentation rate; CESC cis rs7208859 0.673 rs11655623 chr17:29162173 T/C cg19761014 chr17:28927070 LRRC37B2 0.62 5.24 0.31 3.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg04944784 chr2:26401820 FAM59B -0.65 -7.4 -0.41 1.8e-12 Gut microbiome composition (summer); CESC trans rs7922314 0.571 rs61865719 chr10:64741119 C/T cg06935979 chr1:232941706 KIAA1383 -0.63 -6.02 -0.35 5.66e-9 Cutaneous psoriasis; CESC cis rs12142240 0.698 rs56909107 chr1:46808224 A/C cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.98 10.55 0.54 5.96e-22 Platelet count; CESC cis rs12220238 0.908 rs4746179 chr10:75940169 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.75 0.33 2.43e-8 Soluble interleukin-2 receptor subunit alpha; CESC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg02569458 chr12:86230093 RASSF9 0.49 7.28 0.41 3.89e-12 Major depressive disorder; CESC cis rs7635838 0.684 rs2606758 chr3:11353064 G/A cg00170343 chr3:11313890 ATG7 0.54 7.66 0.43 3.45e-13 HDL cholesterol; CESC cis rs8002861 0.846 rs12867732 chr13:44483084 C/A cg14210620 chr13:44453864 C13orf31;CCDC122 -0.43 -5.57 -0.32 6.35e-8 Leprosy; CESC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 11.48 0.58 4.99e-25 Platelet count; CESC cis rs2243480 0.901 rs73142137 chr7:65343442 A/T cg25894440 chr7:65020034 NA -0.63 -5.42 -0.32 1.33e-7 Diabetic kidney disease; CESC cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg10556349 chr10:835070 NA 0.55 5.22 0.31 3.6e-7 Eosinophil percentage of granulocytes; CESC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg21782813 chr7:2030301 MAD1L1 0.52 7.38 0.41 2.03e-12 Bipolar disorder and schizophrenia; CESC cis rs12621445 1 rs12621445 chr2:24154964 C/T cg20701182 chr2:24300061 SF3B14 0.79 6.9 0.39 3.91e-11 Immature fraction of reticulocytes; CESC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg20151795 chr6:28129481 ZNF389 0.44 5.57 0.32 6.17e-8 Depression; CESC trans rs9914544 0.628 rs4924924 chr17:18677774 C/G cg04702396 chr17:15466718 FAM18B2 0.55 6.79 0.38 7.52e-11 Educational attainment (years of education); CESC cis rs11235843 0.636 rs1464908 chr11:73402679 A/C cg18195628 chr11:73498948 MRPL48 -0.48 -5.27 -0.31 2.83e-7 Hand grip strength; CESC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.79 10.52 0.54 7.36e-22 Height; CESC cis rs9926296 0.656 rs2376881 chr16:89827011 C/G cg04287289 chr16:89883240 FANCA 0.59 7.64 0.43 3.87e-13 Vitiligo; CESC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.47 6.08 0.35 4.06e-9 Tonsillectomy; CESC trans rs853679 0.556 rs34588114 chr6:28080628 C/A cg06606381 chr12:133084897 FBRSL1 -1.1 -8.36 -0.46 3.51e-15 Depression; CESC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.8e-9 Prudent dietary pattern; CESC cis rs847577 0.575 rs41278842 chr7:97815999 A/G cg21770322 chr7:97807741 LMTK2 -0.49 -7.12 -0.4 1.04e-11 Breast cancer; CESC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg12963246 chr6:28129442 ZNF389 0.5 6.4 0.37 6.93e-10 Parkinson's disease; CESC cis rs763014 0.931 rs62030903 chr16:638323 T/A cg09263875 chr16:632152 PIGQ 0.69 11.33 0.57 1.61e-24 Height; CESC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg12963246 chr6:28129442 ZNF389 0.54 7.12 0.4 1.02e-11 Depression; CESC cis rs10392 0.571 rs4812335 chr20:37537612 C/T cg27552599 chr20:37590471 DHX35 0.37 5.38 0.31 1.61e-7 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC trans rs1728785 0.901 rs698715 chr16:68560896 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.39 0.41 1.96e-12 Ulcerative colitis; CESC cis rs35146811 0.961 rs35991721 chr7:99728790 G/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.48 5.77 0.33 2.16e-8 Coronary artery disease; CESC trans rs7829975 0.742 rs882462 chr8:8678530 G/A cg21775007 chr8:11205619 TDH 0.41 6.04 0.35 5.29e-9 Mood instability; CESC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg11890956 chr21:40555474 PSMG1 1.17 21.57 0.8 2.76e-60 Cognitive function; CESC cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg16240275 chr20:61666158 NCRNA00029 0.5 8.96 0.48 6.1e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs11122272 0.705 rs2790879 chr1:231534389 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.47 -6.03 -0.35 5.57e-9 Hemoglobin concentration; CESC trans rs17685 0.753 rs7788763 chr7:75651665 T/C cg19862616 chr7:65841803 NCRNA00174 -0.82 -11.9 -0.59 1.95e-26 Coffee consumption;Coffee consumption (cups per day); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10909163 chr13:41635251 WBP4 0.52 6.1 0.35 3.8e-9 Gut microbiome composition (summer); CESC trans rs4596713 0.508 rs12056979 chr9:71778946 A/G cg16512924 chr15:28394682 HERC2 0.48 6.14 0.35 2.95e-9 Headache; CESC cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg12826209 chr6:26865740 GUSBL1 0.76 8.73 0.47 2.93e-16 Intelligence (multi-trait analysis); CESC cis rs11098499 0.955 rs4145951 chr4:120155817 A/G cg24375607 chr4:120327624 NA 0.42 5.05 0.3 8.26e-7 Corneal astigmatism; CESC cis rs6005807 0.543 rs2235432 chr22:29169420 T/G cg15103426 chr22:29168792 CCDC117 0.5 5.16 0.3 4.89e-7 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; CESC cis rs1178968 0.688 rs2528708 chr7:72788583 C/A cg25889504 chr7:72793014 NA 0.44 5.13 0.3 5.64e-7 Triglyceride levels; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg26334671 chr3:172037094 FNDC3B 0.43 6.01 0.35 6.15e-9 Prevalent atrial fibrillation; CESC cis rs208520 0.955 rs12204033 chr6:67001525 T/C cg07460842 chr6:66804631 NA 0.77 8.99 0.48 4.98e-17 Exhaled nitric oxide output; CESC cis rs3020736 0.500 rs2413672 chr22:42513261 C/T cg04733989 chr22:42467013 NAGA -0.78 -11.9 -0.59 1.87e-26 Autism spectrum disorder or schizophrenia; CESC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg21724239 chr8:58056113 NA 0.58 5.23 0.31 3.48e-7 Developmental language disorder (linguistic errors); CESC cis rs1572438 0.896 rs9405366 chr6:858296 A/C cg21062780 chr6:887772 NA -0.39 -5.52 -0.32 8.25e-8 Aging; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg16554516 chr1:206680868 RASSF5 0.49 6.03 0.35 5.45e-9 Psoriatic arthritis; CESC cis rs922182 0.547 rs12594348 chr15:64269127 C/T cg24729988 chr15:64271149 DAPK2 -0.6 -8.97 -0.48 5.6e-17 Blood protein levels; CESC trans rs7615952 0.799 rs13315434 chr3:125641394 T/G cg07211511 chr3:129823064 LOC729375 -1.13 -16.52 -0.71 1.28e-42 Blood pressure (smoking interaction); CESC cis rs2302190 1.000 rs2302190 chr17:56584508 A/G cg25885038 chr17:56607967 SEPT4 -0.37 -5.31 -0.31 2.3e-7 Vitamin D levels; CESC cis rs11690935 0.959 rs6724337 chr2:172735329 C/T cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.51 -0.67 1.65e-35 Schizophrenia; CESC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg18252515 chr7:66147081 NA 0.46 5.97 0.34 7.62e-9 Aortic root size; CESC cis rs57506017 0.585 rs3823612 chr7:12258755 C/G cg23422036 chr7:12250390 TMEM106B 0.39 5.26 0.31 2.93e-7 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26859690 chr20:3869672 PANK2 0.55 6.51 0.37 3.82e-10 Gut microbiome composition (summer); CESC cis rs6988985 0.560 rs5301 chr8:143955273 T/C cg10324643 chr8:143916377 GML 0.35 5.22 0.31 3.63e-7 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CESC cis rs12549902 0.966 rs4737000 chr8:41509727 A/C cg00088007 chr8:41504566 NKX6-3 0.29 5.05 0.3 8.26e-7 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; CESC cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg10556349 chr10:835070 NA 0.57 5.48 0.32 9.88e-8 Eosinophil percentage of granulocytes; CESC trans rs2797160 0.651 rs9491503 chr6:126031682 G/A cg05039488 chr6:79577232 IRAK1BP1 0.54 7.23 0.41 5.04e-12 Endometrial cancer; CESC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg10691866 chr7:65817282 TPST1 0.3 5.06 0.3 7.74e-7 Aortic root size; CESC cis rs2832077 0.527 rs11088095 chr21:30223188 A/T cg24692254 chr21:30365293 RNF160 -0.66 -9.15 -0.49 1.56e-17 Cognitive test performance; CESC cis rs6032067 0.704 rs62205505 chr20:43874856 C/T cg10761708 chr20:43804764 PI3 0.51 6.13 0.35 3.16e-9 Blood protein levels; CESC cis rs9911578 0.805 rs12601867 chr17:56455260 C/G cg12560992 chr17:57184187 TRIM37 -0.76 -11.97 -0.59 1.14e-26 Intelligence (multi-trait analysis); CESC cis rs4642101 0.662 rs9840766 chr3:12821870 G/A cg24848339 chr3:12840334 CAND2 0.41 6.33 0.36 1.06e-9 QRS complex (12-leadsum); CESC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -6.96 -0.39 2.6e-11 Personality dimensions; CESC cis rs2404602 0.735 rs2957614 chr15:76696635 C/T cg23625390 chr15:77176239 SCAPER 0.42 5.87 0.34 1.27e-8 Blood metabolite levels; CESC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg00166722 chr3:10149974 C3orf24 0.49 6.04 0.35 5.3e-9 Alzheimer's disease; CESC cis rs60154123 0.505 rs7540237 chr1:210053325 C/T cg25204440 chr1:209979598 IRF6 0.69 6.43 0.37 5.76e-10 Coronary artery disease; CESC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg14262678 chr6:151773367 RMND1;C6orf211 0.64 9.08 0.49 2.57e-17 Menarche (age at onset); CESC cis rs9487051 0.676 rs6928622 chr6:109595112 C/T cg21918786 chr6:109611834 NA -0.37 -5.44 -0.32 1.22e-7 Reticulocyte fraction of red cells; CESC cis rs17209837 0.915 rs17149637 chr7:87085209 G/A cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC trans rs61931739 0.500 rs11513287 chr12:34584351 G/A cg13010199 chr12:38710504 ALG10B 0.52 6.63 0.38 1.86e-10 Morning vs. evening chronotype; CESC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg24549020 chr5:56110836 MAP3K1 0.65 7.54 0.42 7.42e-13 Initial pursuit acceleration; CESC trans rs208520 1.000 rs208537 chr6:66963544 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -9.42 -0.5 2.36e-18 Exhaled nitric oxide output; CESC cis rs7647973 1.000 rs9871024 chr3:49554241 T/C cg06212747 chr3:49208901 KLHDC8B -0.6 -7.97 -0.44 4.76e-14 Menarche (age at onset); CESC cis rs12447180 0.527 rs4782365 chr16:88516171 C/G cg26884787 chr16:88543447 ZFPM1 0.34 5.2 0.3 3.96e-7 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs34779708 0.897 rs35784065 chr10:35353574 C/T cg04310649 chr10:35416472 CREM -0.5 -5.89 -0.34 1.15e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs6740322 0.748 rs6720087 chr2:43468745 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.68 7.76 0.43 1.9e-13 Coronary artery disease; CESC cis rs7845219 0.544 rs2945554 chr8:95939594 C/A cg23172400 chr8:95962367 TP53INP1 -0.37 -6.79 -0.38 7.51e-11 Type 2 diabetes; CESC cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg05347473 chr6:146136440 FBXO30 -0.55 -6.97 -0.39 2.54e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs11122272 0.735 rs2808602 chr1:231537303 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.44 -0.42 1.38e-12 Hemoglobin concentration; CESC cis rs1865760 0.566 rs9348706 chr6:26065481 G/C cg16482183 chr6:26056742 HIST1H1C 0.39 5.46 0.32 1.12e-7 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24886033 chr12:10265096 NA -0.52 -7.16 -0.4 7.88e-12 Gut microbiota (bacterial taxa); CESC cis rs9287719 0.967 rs7600728 chr2:10739999 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs2929278 0.588 rs1975364 chr15:44150189 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.48 7.31 0.41 3.25e-12 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23652038 chr6:111136640 CDK19 -0.49 -6.08 -0.35 4.2e-9 Ulcerative colitis; CESC cis rs34330 0.562 rs12229100 chr12:12865836 A/G cg09462578 chr12:12878428 APOLD1 0.79 8.76 0.47 2.41e-16 Systemic lupus erythematosus; CESC cis rs965469 0.779 rs6037528 chr20:3260978 A/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.34 -0.31 1.99e-7 IFN-related cytopenia; CESC cis rs7772486 0.686 rs9386131 chr6:146121608 G/A cg05347473 chr6:146136440 FBXO30 0.52 6.84 0.39 5.37e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs796364 0.616 rs1523818 chr2:200684704 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.58 5.45 0.32 1.15e-7 Schizophrenia; CESC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg19626725 chr5:178986131 RUFY1 -0.4 -6.24 -0.36 1.7e-9 Lung cancer; CESC cis rs9611565 0.694 rs202637 chr22:41853928 A/G cg06481639 chr22:41940642 POLR3H 0.62 6.2 0.36 2.19e-9 Vitiligo; CESC cis rs3733585 0.699 rs6449174 chr4:9966422 C/T cg11266682 chr4:10021025 SLC2A9 -0.54 -9.99 -0.52 3.71e-20 Cleft plate (environmental tobacco smoke interaction); CESC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg11764359 chr7:65958608 NA 0.73 10.38 0.54 2.09e-21 Aortic root size; CESC cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg00701064 chr4:6280414 WFS1 0.69 11.74 0.58 6.7e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs11098499 1.000 rs11098499 chr4:120187611 C/T cg24375607 chr4:120327624 NA 0.41 5.03 0.3 9e-7 Corneal astigmatism; CESC cis rs7617773 0.817 rs936427 chr3:48301074 A/G cg11946769 chr3:48343235 NME6 -0.88 -11.65 -0.58 1.34e-25 Coronary artery disease; CESC cis rs6772849 1.000 rs2712379 chr3:128309060 C/T cg16766828 chr3:128327626 NA -0.32 -5.12 -0.3 5.95e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg19678392 chr7:94953810 PON1 -0.57 -8.74 -0.47 2.68e-16 Paraoxonase activity; CESC cis rs2688608 0.592 rs11000757 chr10:75486815 T/C cg23231163 chr10:75533350 FUT11 -0.35 -5.27 -0.31 2.81e-7 Inflammatory bowel disease; CESC cis rs7084402 0.967 rs2842083 chr10:60329230 A/C cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 7.68 0.43 3.04e-13 Menopause (age at onset); CESC cis rs7084402 0.967 rs1658452 chr10:60311114 A/T cg07615347 chr10:60278583 BICC1 0.59 9.34 0.5 4.21e-18 Refractive error; CESC cis rs9486719 0.690 rs2092094 chr6:96844123 G/C cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs12530845 0.945 rs59664351 chr7:135314717 C/A cg23117316 chr7:135346802 PL-5283 -0.44 -5.6 -0.33 5.48e-8 Red blood cell traits; CESC cis rs2295499 0.649 rs55679022 chr4:2707325 T/G cg08330972 chr4:2403930 ZFYVE28 -0.33 -5.41 -0.32 1.41e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs6543140 0.927 rs917999 chr2:103067869 G/A cg04239558 chr2:103089729 SLC9A4 0.45 5.66 0.33 3.94e-8 Blood protein levels; CESC cis rs1799949 0.965 rs799912 chr17:41257134 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.48 6.9 0.39 3.86e-11 Menopause (age at onset); CESC cis rs16854884 0.739 rs56196484 chr3:143786160 G/T cg06585982 chr3:143692056 C3orf58 0.47 5.98 0.34 7.16e-9 Economic and political preferences (feminism/equality); CESC cis rs992157 0.735 rs13393821 chr2:219076742 C/G cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.57 0.51 8.06e-19 Colorectal cancer; CESC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg13012494 chr21:47604986 C21orf56 0.48 6.55 0.37 2.96e-10 Testicular germ cell tumor; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00167275 chr10:88854588 FAM35A;GLUD1 -0.44 -6.1 -0.35 3.73e-9 Ulcerative colitis; CESC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg27535305 chr1:53392650 SCP2 -0.34 -5.55 -0.32 6.99e-8 Monocyte count; CESC cis rs7219021 0.739 rs58376900 chr17:46962853 C/G cg16584676 chr17:46985605 UBE2Z -0.66 -7.42 -0.41 1.61e-12 Schizophrenia or bipolar disorder; CESC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg07507251 chr3:52567010 NT5DC2 0.34 5.45 0.32 1.15e-7 Bipolar disorder; CESC cis rs4555082 0.834 rs2816652 chr14:105712493 C/T cg06808227 chr14:105710500 BRF1 -0.51 -5.81 -0.34 1.77e-8 Mean platelet volume;Platelet distribution width; CESC cis rs1008375 1.000 rs56308330 chr4:17643050 G/A cg15017067 chr4:17643749 FAM184B 0.37 5.23 0.31 3.39e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs938554 0.657 rs9994216 chr4:9984541 G/T cg00071950 chr4:10020882 SLC2A9 0.51 6.7 0.38 1.22e-10 Blood metabolite levels; CESC cis rs7592578 0.882 rs7569128 chr2:191446691 C/A cg10560079 chr2:191398806 TMEM194B 0.62 5.48 0.32 1e-7 Diastolic blood pressure; CESC cis rs763121 0.819 rs4560233 chr22:38982442 A/T cg06022373 chr22:39101656 GTPBP1 0.82 12.13 0.6 3.16e-27 Menopause (age at onset); CESC cis rs7223966 1.000 rs9893348 chr17:61676534 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.47 5.12 0.3 6.01e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg04944784 chr2:26401820 FAM59B -0.66 -7.62 -0.42 4.62e-13 Gut microbiome composition (summer); CESC cis rs2066819 1.000 rs2066808 chr12:56737973 A/G cg26316697 chr12:56727976 PAN2 0.72 6.9 0.39 3.81e-11 Psoriasis vulgaris; CESC cis rs11828289 0.660 rs11027043 chr11:23212893 C/T cg20040320 chr11:23191996 NA -0.72 -5.98 -0.35 7.05e-9 Cancer; CESC cis rs965469 0.779 rs6051780 chr20:3334167 A/C cg17110299 chr20:3385021 C20orf194 0.4 5.24 0.31 3.22e-7 IFN-related cytopenia; CESC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg27535305 chr1:53392650 SCP2 -0.33 -5.62 -0.33 4.92e-8 Monocyte count; CESC cis rs9911578 1.000 rs1267545 chr17:56646909 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.16 0.3 4.79e-7 Intelligence (multi-trait analysis); CESC cis rs910316 0.712 rs175015 chr14:75457075 A/C cg11812906 chr14:75593930 NEK9 -0.8 -12.6 -0.61 7.66e-29 Height; CESC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg16145915 chr7:1198662 ZFAND2A -0.5 -5.64 -0.33 4.29e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9291683 0.704 rs11726271 chr4:10098192 G/A cg00071950 chr4:10020882 SLC2A9 -0.56 -8.71 -0.47 3.35e-16 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03661160 chr7:97881541 TECPR1 0.57 7.02 0.4 1.87e-11 Gut microbiome composition (summer); CESC cis rs919433 0.817 rs10931780 chr2:198175297 G/C cg10820045 chr2:198174542 NA -0.44 -7.01 -0.4 2e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6032067 0.929 rs17333555 chr20:43809761 C/T cg11264863 chr20:43835661 SEMG1 0.49 5.36 0.31 1.81e-7 Blood protein levels; CESC cis rs919433 0.963 rs1429417 chr2:198158171 T/G cg03934865 chr2:198174659 NA -0.47 -7.1 -0.4 1.12e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs6570726 0.967 rs373527 chr6:145801861 C/T cg23711669 chr6:146136114 FBXO30 0.73 10.72 0.55 1.63e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs2235642 0.859 rs12599207 chr16:1606445 A/G cg03771183 chr16:1608904 IFT140 0.41 5.93 0.34 9.31e-9 Coronary artery disease; CESC cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.67e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg00149659 chr3:10157352 C3orf10 0.73 8.54 0.46 1.05e-15 Alzheimer's disease; CESC cis rs9467711 0.606 rs9379851 chr6:26354780 A/C cg12826209 chr6:26865740 GUSBL1 0.62 5.3 0.31 2.42e-7 Autism spectrum disorder or schizophrenia; CESC trans rs7947523 0.813 rs4999940 chr11:80942337 C/T cg16956456 chr5:172483378 C5orf41 0.48 6.28 0.36 1.35e-9 Emphysema imaging phenotypes; CESC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.75 -10.27 -0.53 4.65e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9487051 0.714 rs9487053 chr6:109619697 T/C cg12927641 chr6:109611667 NA -0.36 -5.25 -0.31 3.08e-7 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01671314 chr6:135502610 MYB 0.59 6.55 0.37 3.06e-10 Gut microbiome composition (summer); CESC cis rs870825 0.616 rs10013562 chr4:185610486 A/G cg04058563 chr4:185651563 MLF1IP 0.61 7.0 0.39 2.15e-11 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00670742 chr2:87034831 CD8A 0.51 6.05 0.35 5.01e-9 Gut microbiome composition (summer); CESC cis rs847577 0.569 rs2394817 chr7:97690438 C/T cg21770322 chr7:97807741 LMTK2 0.81 14.38 0.66 4.75e-35 Breast cancer; CESC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg13393036 chr8:95962371 TP53INP1 -0.51 -11.09 -0.56 9.71e-24 Type 2 diabetes; CESC cis rs6540559 0.673 rs17015361 chr1:210018901 C/G cg22029157 chr1:209979665 IRF6 0.66 7.44 0.42 1.4e-12 Cleft lip with or without cleft palate; CESC cis rs6893300 0.961 rs11738269 chr5:179209059 A/C cg14593053 chr5:179126677 CANX 0.52 5.8 0.34 1.86e-8 Resting heart rate; CESC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg14393609 chr7:65229607 NA -0.47 -6.27 -0.36 1.49e-9 Aortic root size; CESC cis rs2997447 0.846 rs61775427 chr1:26408768 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.61 5.37 0.31 1.71e-7 QRS complex (12-leadsum); CESC cis rs919433 0.929 rs4850788 chr2:198182940 G/A cg10820045 chr2:198174542 NA -0.44 -6.86 -0.39 4.76e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs12586317 0.547 rs74462850 chr14:35500093 G/T cg05294307 chr14:35346193 BAZ1A -0.51 -5.4 -0.31 1.49e-7 Psoriasis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12792894 chr1:115123975 BCAS2 0.42 6.11 0.35 3.54e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs367943 1.000 rs348930 chr5:112814763 T/C cg12552261 chr5:112820674 MCC -0.62 -7.72 -0.43 2.34e-13 Type 2 diabetes; CESC cis rs2836974 0.931 rs2776309 chr21:40715791 A/G cg11644478 chr21:40555479 PSMG1 0.95 13.43 0.64 9.81e-32 Cognitive function; CESC cis rs2228479 0.850 rs3785279 chr16:89824562 G/C cg04013166 chr16:89971882 TCF25 0.79 6.75 0.38 9.14e-11 Skin colour saturation; CESC cis rs920590 0.684 rs57837509 chr8:19670088 A/G cg03894339 chr8:19674705 INTS10 0.68 7.78 0.43 1.59e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg18904891 chr8:8559673 CLDN23 0.67 7.49 0.42 1.01e-12 Obesity-related traits; CESC cis rs9467711 0.606 rs9379854 chr6:26362854 T/C cg14345882 chr6:26364793 BTN3A2 0.62 6.53 0.37 3.29e-10 Autism spectrum disorder or schizophrenia; CESC cis rs34779708 0.966 rs4934538 chr10:35472150 T/C cg04310649 chr10:35416472 CREM -0.51 -6.27 -0.36 1.43e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs4523957 0.748 rs12603592 chr17:2119818 A/T cg16513277 chr17:2031491 SMG6 -0.61 -8.23 -0.45 8.58e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg04267008 chr7:1944627 MAD1L1 -0.74 -10.0 -0.52 3.37e-20 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs59751489 chr4:98933802 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.92 9.69 0.51 3.29e-19 Platelet count; CESC cis rs6088580 0.634 rs1890002 chr20:32919219 A/G cg06115741 chr20:33292138 TP53INP2 -0.43 -5.53 -0.32 7.76e-8 Glomerular filtration rate (creatinine); CESC trans rs61931739 0.500 rs7488438 chr12:34531359 G/T cg13010199 chr12:38710504 ALG10B 0.52 6.65 0.38 1.7e-10 Morning vs. evening chronotype; CESC cis rs12900413 0.687 rs28493563 chr15:90309505 C/T cg24249390 chr15:90295951 MESP1 -0.4 -5.5 -0.32 8.88e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs7246657 0.943 rs12981532 chr19:37889280 G/A cg23950597 chr19:37808831 NA -0.61 -6.19 -0.36 2.31e-9 Coronary artery calcification; CESC cis rs8133932 0.564 rs452797 chr21:47348455 C/G cg14185626 chr21:47401492 COL6A1 -0.48 -5.33 -0.31 2.07e-7 Schizophrenia; CESC cis rs2011503 1.000 rs75667002 chr19:19592232 T/A cg11584989 chr19:19387371 SF4 0.62 7.22 0.41 5.54e-12 Bipolar disorder; CESC cis rs17401966 0.838 rs61775885 chr1:10281445 T/C cg15208524 chr1:10270712 KIF1B 0.42 5.45 0.32 1.17e-7 Hepatocellular carcinoma; CESC cis rs473651 0.935 rs483166 chr2:239346641 C/T cg21699342 chr2:239360505 ASB1 -0.54 -9.38 -0.5 2.98e-18 Multiple system atrophy; CESC trans rs6794880 1.000 rs6794880 chr3:84451512 G/A cg03554283 chr8:76319451 NA -0.56 -6.08 -0.35 4.27e-9 Body mass index (joint analysis main effects and smoking interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs17209837 1.000 rs2302387 chr7:87092185 G/A cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC cis rs240110 0.515 rs12530388 chr6:101329173 A/C cg09795085 chr6:101329169 ASCC3 0.46 5.98 0.34 7.08e-9 Neuroticism; CESC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg04234412 chr22:24373322 LOC391322 -0.41 -5.88 -0.34 1.21e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7575873 1 rs7575873 chr2:23962647 A/G cg08917208 chr2:24149416 ATAD2B 1.13 10.18 0.53 9.42e-21 Birth weight; CESC cis rs7264396 0.561 rs6058388 chr20:34571846 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.7 -8.9 -0.48 9.01e-17 Total cholesterol levels; CESC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg03647317 chr4:187891568 NA -0.38 -5.64 -0.33 4.38e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 13.32 0.63 2.4e-31 Platelet count; CESC cis rs9902453 0.868 rs7212162 chr17:28321328 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 9.9 0.52 7e-20 Coffee consumption (cups per day); CESC trans rs2727020 0.576 rs12293522 chr11:49558425 T/A cg15704280 chr7:45808275 SEPT13 -0.95 -17.21 -0.73 4.36e-45 Coronary artery disease; CESC cis rs9388451 0.839 rs9321054 chr6:126079968 A/G cg05901451 chr6:126070800 HEY2 0.65 9.51 0.5 1.21e-18 Brugada syndrome; CESC cis rs1707322 0.963 rs4553121 chr1:46375253 G/A cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg21963583 chr11:68658836 MRPL21 0.4 5.55 0.32 7.03e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2842992 0.750 rs2758354 chr6:160125854 A/G cg11366901 chr6:160182831 ACAT2 0.82 10.45 0.54 1.24e-21 Age-related macular degeneration (geographic atrophy); CESC cis rs1499614 1.000 rs1267818 chr7:66107024 C/T cg12463550 chr7:65579703 CRCP 0.75 5.85 0.34 1.42e-8 Gout; CESC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.74 0.38 9.59e-11 Bipolar disorder; CESC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC cis rs78456975 1.000 rs78456975 chr2:1554190 T/G cg26248373 chr2:1572462 NA -0.58 -5.22 -0.31 3.68e-7 Placebo response in major depressive disorder (% change in symptom score); CESC trans rs17508449 0.819 rs41352847 chr1:114189880 G/A cg23028848 chr11:57092561 TNKS1BP1 -0.75 -6.05 -0.35 4.88e-9 Leprosy; CESC cis rs4654899 0.758 rs7556221 chr1:21455559 C/G cg05370193 chr1:21551575 ECE1 0.38 5.82 0.34 1.7e-8 Superior frontal gyrus grey matter volume; CESC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.71 6.23 0.36 1.82e-9 Platelet count; CESC trans rs208520 0.690 rs12201156 chr6:66720874 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.51 0.58 3.9e-25 Exhaled nitric oxide output; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13195266 chr15:75660973 MAN2C1 -0.51 -6.04 -0.35 5.24e-9 Ulcerative colitis; CESC cis rs2235544 0.513 rs10158824 chr1:54480398 C/G cg09175620 chr1:54484536 LDLRAD1 0.28 5.1 0.3 6.35e-7 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg04915975 chr3:139063070 MRPS22 0.46 6.09 0.35 3.94e-9 Myopia (pathological); CESC cis rs4953076 0.573 rs67537903 chr2:44422111 G/A cg04920474 chr2:44395004 PPM1B 0.6 7.62 0.42 4.44e-13 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21042902 chr5:176873577 PRR7 0.54 6.02 0.35 5.69e-9 Gut microbiome composition (summer); CESC cis rs72829446 0.556 rs9907042 chr17:7402985 A/G cg02795151 chr17:7402630 POLR2A -0.62 -6.63 -0.38 1.83e-10 Androgen levels; CESC cis rs9303401 0.538 rs3785493 chr17:56472119 G/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.9 -9.72 -0.51 2.6e-19 Cognitive test performance; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07871153 chr10:79602008 DLG5 -0.47 -6.39 -0.37 7.38e-10 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21578066 chr4:111119297 ELOVL6 -0.7 -9.07 -0.49 2.83e-17 Gut microbiome composition (summer); CESC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg16325326 chr1:53192061 ZYG11B -0.89 -15.32 -0.69 2.26e-38 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12515684 chr10:8203261 NA -0.59 -7.0 -0.4 2.12e-11 Gut microbiome composition (summer); CESC trans rs61931739 0.517 rs11053067 chr12:34191391 T/C cg13010199 chr12:38710504 ALG10B 0.48 5.99 0.35 6.66e-9 Morning vs. evening chronotype; CESC cis rs1348850 0.632 rs11678875 chr2:178509068 A/G cg23306229 chr2:178417860 TTC30B 0.58 7.35 0.41 2.41e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11098499 0.874 rs6832670 chr4:120118792 A/G cg09307838 chr4:120376055 NA 0.74 9.2 0.49 1.07e-17 Corneal astigmatism; CESC cis rs654384 0.613 rs4236342 chr7:4177712 A/C cg26275264 chr7:4183598 SDK1 0.36 5.18 0.3 4.29e-7 Positive affect; CESC cis rs2228479 0.850 rs62054609 chr16:89816569 C/A cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs10883723 0.810 rs2296588 chr10:104248087 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.48 0.42 1.09e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs703842 0.616 rs1875125 chr12:58227241 T/G cg02175503 chr12:58329896 NA 0.48 5.99 0.35 6.99e-9 Multiple sclerosis; CESC cis rs137699 0.959 rs5757631 chr22:39755953 T/C cg24399712 chr22:39784796 NA -0.4 -5.19 -0.3 4.23e-7 IgG glycosylation; CESC cis rs854765 0.547 rs2955380 chr17:17944349 A/G cg16928487 chr17:17741425 SREBF1 0.55 9.13 0.49 1.86e-17 Total body bone mineral density; CESC cis rs644799 1.000 rs534497 chr11:95562868 C/G cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.74 0.38 9.71e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1983170 1.000 rs12563578 chr1:91993702 T/C cg02896835 chr1:92012615 NA 0.58 6.58 0.37 2.54e-10 Eosinophil percentage of white cells; CESC cis rs3126085 0.560 rs3120667 chr1:152318161 A/G cg03465714 chr1:152285911 FLG 0.42 5.05 0.3 8.42e-7 Atopic dermatitis; CESC trans rs875971 0.895 rs3857684 chr7:65938158 G/C cg26939375 chr7:64535504 NA 0.47 6.07 0.35 4.45e-9 Aortic root size; CESC cis rs10791097 0.765 rs4622274 chr11:130729486 C/T cg09137382 chr11:130731461 NA 0.37 5.4 0.32 1.46e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs35110281 0.681 rs162343 chr21:44957072 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -9.52 -0.5 1.12e-18 Mean corpuscular volume; CESC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg21017887 chr14:105400489 NA 0.41 6.8 0.39 7.06e-11 Rheumatoid arthritis; CESC cis rs9858542 0.953 rs9858280 chr3:49597737 T/C cg07274523 chr3:49395745 GPX1 0.65 8.45 0.46 1.91e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9611565 0.546 rs739132 chr22:42123099 A/T cg06634786 chr22:41940651 POLR3H 0.65 6.57 0.37 2.6200000000000003e-10 Vitiligo; CESC cis rs9911578 1.000 rs9807057 chr17:56889952 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.24 0.31 3.23e-7 Intelligence (multi-trait analysis); CESC cis rs5769765 0.646 rs9627789 chr22:50300562 A/G cg02269571 chr22:50332266 NA -0.52 -6.31 -0.36 1.18e-9 Schizophrenia; CESC cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg19077165 chr18:44547161 KATNAL2 0.65 10.07 0.53 2.03e-20 Personality dimensions; CESC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg17971929 chr21:40555470 PSMG1 -0.87 -12.71 -0.62 3.27e-29 Cognitive function; CESC cis rs2228479 0.557 rs62054639 chr16:89821489 C/T cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg19901468 chr14:105411992 AHNAK2 -0.61 -8.78 -0.47 2.08e-16 Rheumatoid arthritis; CESC cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg03433033 chr1:76189801 ACADM 0.57 5.65 0.33 4.21e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4953076 0.573 rs2054005 chr2:44401843 C/T cg04920474 chr2:44395004 PPM1B 0.56 7.24 0.41 4.78e-12 Height; CESC cis rs8114671 0.562 rs1013677 chr20:33468793 C/T cg07148914 chr20:33460835 GGT7 0.44 6.11 0.35 3.63e-9 Height; CESC cis rs7851660 1.000 rs7851660 chr9:100610759 C/A cg13688889 chr9:100608707 NA -0.68 -10.52 -0.54 7.66e-22 Strep throat; CESC cis rs6963495 0.818 rs114865717 chr7:105158526 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs61931739 0.500 rs6488224 chr12:34537205 T/C cg06521331 chr12:34319734 NA -0.37 -5.15 -0.3 5.19e-7 Morning vs. evening chronotype; CESC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg08470875 chr2:26401718 FAM59B -0.62 -6.71 -0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs4704187 0.687 rs58067979 chr5:74523555 C/T cg03227963 chr5:74354835 NA 0.28 5.13 0.3 5.48e-7 Response to amphetamines; CESC cis rs6502050 0.871 rs8072702 chr17:80074280 C/T cg23985595 chr17:80112537 CCDC57 0.41 6.4 0.37 6.88e-10 Life satisfaction; CESC cis rs2243480 1.000 rs781156 chr7:65479141 C/A cg25894440 chr7:65020034 NA -0.65 -5.63 -0.33 4.5e-8 Diabetic kidney disease; CESC cis rs7927771 0.832 rs4992357 chr11:47393638 C/T cg05585544 chr11:47624801 NA -0.43 -6.41 -0.37 6.6e-10 Subjective well-being; CESC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg12373951 chr3:133503437 NA 0.52 7.77 0.43 1.7e-13 Iron status biomarkers; CESC cis rs4132509 1.000 rs2290754 chr1:243806268 A/C cg21452805 chr1:244014465 NA 0.44 5.2 0.3 3.91e-7 RR interval (heart rate); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg11253136 chr11:70116457 PPFIA1 0.54 6.89 0.39 3.96e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg26750617 chr12:132293702 NA -0.42 -5.43 -0.32 1.25e-7 Migraine; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03600697 chr3:142315064 PLS1 -0.43 -6.05 -0.35 4.9e-9 Gut microbiota (bacterial taxa); CESC cis rs7107174 0.892 rs3018313 chr11:77989644 C/T cg02023728 chr11:77925099 USP35 0.48 6.56 0.37 2.79e-10 Testicular germ cell tumor; CESC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg06108461 chr20:60628389 TAF4 -0.79 -10.4 -0.54 1.85e-21 Body mass index; CESC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg02807482 chr3:125708958 NA -0.4 -5.32 -0.31 2.26e-7 Blood pressure (smoking interaction); CESC trans rs7902708 0.841 rs73333526 chr10:54424528 A/G cg26219051 chr22:43739629 SCUBE1 -0.48 -6.07 -0.35 4.3e-9 Bone properties (heel); CESC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg06456125 chr7:65229604 NA 0.4 5.25 0.31 3.09e-7 Aortic root size; CESC cis rs9875589 0.509 rs2733556 chr3:14100172 A/T cg19554555 chr3:13937349 NA -0.46 -5.9 -0.34 1.09e-8 Ovarian reserve; CESC cis rs56399783 0.901 rs73051444 chr7:2866529 G/A cg19731401 chr7:2775893 GNA12 0.64 5.6 0.33 5.44e-8 Childhood ear infection; CESC cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg21573476 chr21:45109991 RRP1B -0.37 -5.25 -0.31 3.13e-7 Mean corpuscular volume; CESC trans rs2727020 0.553 rs3862350 chr11:49595912 A/C cg03929089 chr4:120376271 NA -0.82 -12.21 -0.6 1.63e-27 Coronary artery disease; CESC cis rs7084402 0.935 rs10763559 chr10:60347410 C/T cg07615347 chr10:60278583 BICC1 0.54 8.32 0.46 4.65e-15 Refractive error; CESC cis rs660498 0.507 rs12413784 chr10:27729599 C/G cg25705717 chr10:27608719 NA 0.49 5.83 0.34 1.58e-8 Asthma (childhood onset); CESC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg23281280 chr6:28129359 ZNF389 0.56 7.61 0.42 4.91e-13 Depression; CESC cis rs6121246 0.821 rs7265413 chr20:30317923 G/A cg13852791 chr20:30311386 BCL2L1 0.8 8.55 0.46 1.02e-15 Mean corpuscular hemoglobin; CESC cis rs7264396 1.000 rs224433 chr20:34153850 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -6.03 -0.35 5.61e-9 Total cholesterol levels; CESC cis rs9308433 0.529 rs4655244 chr1:214497580 A/G cg06198575 chr1:214491504 SMYD2 0.49 5.98 0.34 7.22e-9 IgG glycosylation; CESC cis rs2304069 0.545 rs4705404 chr5:149381952 A/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.45 6.15 0.35 2.83e-9 HIV-1 control; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12473036 chr20:62611207 SAMD10;PRPF6 0.51 6.48 0.37 4.4e-10 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg05340658 chr4:99064831 C4orf37 0.63 8.21 0.45 9.8e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1003719 0.751 rs55992706 chr21:38542749 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.57 -7.66 -0.43 3.53e-13 Eye color traits; CESC cis rs3782089 0.793 rs34789990 chr11:65252477 G/T cg21890820 chr11:65308645 LTBP3 0.66 5.66 0.33 3.93e-8 Height; CESC cis rs3916 0.641 rs2393749 chr12:121131891 C/T cg00257296 chr12:120799373 MSI1 0.36 5.44 0.32 1.24e-7 Urinary metabolites (H-NMR features); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07274506 chr1:6614341 TAS1R1;NOL9 -0.39 -6.24 -0.36 1.71e-9 Gambling; CESC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.49 -0.5 1.38e-18 Alzheimer's disease; CESC cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg18305652 chr10:134549665 INPP5A 0.49 7.29 0.41 3.54e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs11608355 0.545 rs9943764 chr12:109905720 G/A cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs8062405 1.000 rs3888190 chr16:28889486 C/A cg08761264 chr16:28874980 SH2B1 -0.46 -5.72 -0.33 2.81e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9811920 0.638 rs796977 chr3:99549723 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -5.81 -0.34 1.74e-8 Axial length; CESC cis rs2979489 1.000 rs2979469 chr8:30285091 C/G cg26383811 chr8:30366931 RBPMS 0.67 8.86 0.48 1.22e-16 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg21535942 chr1:75199100 CRYZ;TYW3 0.44 5.68 0.33 3.52e-8 Resistin levels; CESC cis rs2073300 1.000 rs12625999 chr20:23442085 A/G cg12062639 chr20:23401060 NAPB -0.91 -6.41 -0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs936229 0.656 rs12898397 chr15:75130093 T/C cg17294928 chr15:75287854 SCAMP5 0.43 5.57 0.32 6.13e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs2296342 0.522 rs1536036 chr6:33632014 A/G cg14003231 chr6:33640908 ITPR3 0.32 5.78 0.33 2.14e-8 Schizophrenia; CESC cis rs12983728 0.831 rs79222418 chr19:58664418 T/C cg08687515 chr19:58661962 ZNF329 0.55 5.26 0.31 3.02e-7 Cholesterol, total; CESC cis rs643506 0.790 rs688095 chr11:111678771 T/C cg17089665 chr11:111648010 NA -0.35 -5.11 -0.3 6.19e-7 Breast cancer; CESC trans rs6716963 0.870 rs6748251 chr2:194468524 A/G cg13775856 chr19:36486874 SDHAF1 -0.45 -6.12 -0.35 3.39e-9 Schizophrenia; CESC cis rs3540 0.533 rs1869179 chr15:90895564 A/C cg10434728 chr15:90938212 IQGAP1 0.4 7.09 0.4 1.21e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs3780486 0.757 rs10121987 chr9:33119818 A/G cg20290983 chr6:43655470 MRPS18A 0.96 17.31 0.73 2.01e-45 IgG glycosylation; CESC cis rs9875589 0.509 rs2731336 chr3:14091908 G/A cg19554555 chr3:13937349 NA -0.46 -5.98 -0.35 7.03e-9 Ovarian reserve; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10091738 chr6:26204643 HIST1H4E -0.55 -6.35 -0.36 9.3e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20986421 chr1:201798455 IPO9 0.58 6.43 0.37 5.99e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12588470 chr4:89444909 PIGY 0.64 7.16 0.4 8.1e-12 Gut microbiome composition (summer); CESC cis rs10870270 0.913 rs4880326 chr10:133745547 C/A cg17892150 chr10:133769511 PPP2R2D -0.86 -12.61 -0.61 6.93e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs72781680 1.000 rs12617839 chr2:24166277 A/T cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs2274273 0.967 rs2340931 chr14:55616937 T/G cg04306507 chr14:55594613 LGALS3 0.28 5.66 0.33 3.85e-8 Protein biomarker; CESC cis rs4648845 0.777 rs2477689 chr1:2395538 G/C cg07700843 chr1:2391317 NA -0.49 -9.0 -0.48 4.51e-17 Schizophrenia; CESC trans rs72681920 0.881 rs12504365 chr4:100203037 C/T cg22948791 chr15:71404101 CT62 -0.54 -6.14 -0.35 2.96e-9 Alcohol dependence; CESC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg06028605 chr16:24865363 SLC5A11 -0.54 -8.07 -0.44 2.39e-14 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg17221315 chr6:27791827 HIST1H4J 0.43 5.62 0.33 4.83e-8 Cardiac Troponin-T levels; CESC cis rs6025261 0.761 rs6099359 chr20:55509896 G/T cg04763273 chr20:55502381 NA -0.3 -5.22 -0.31 3.7e-7 Verbal memory performance (delayed recall level); CESC cis rs4460629 0.742 rs11264314 chr1:155078423 C/G cg01019262 chr1:155095195 NA -0.3 -5.1 -0.3 6.49e-7 Serum magnesium levels; CESC cis rs67311347 0.956 rs4974029 chr3:40521318 C/G cg09455208 chr3:40491958 NA 0.5 8.71 0.47 3.31e-16 Renal cell carcinoma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07421368 chr2:67624930 ETAA1 -0.43 -6.14 -0.35 2.93e-9 Gambling; CESC cis rs2072499 0.966 rs1060604 chr1:156184268 T/C cg24450063 chr1:156163899 SLC25A44 0.92 14.11 0.66 4.18e-34 Testicular germ cell tumor; CESC cis rs6541297 0.775 rs4846910 chr1:230291441 C/A cg05784532 chr1:230284198 GALNT2 0.51 5.64 0.33 4.37e-8 Coronary artery disease; CESC cis rs7772486 0.840 rs11155451 chr6:146422524 A/G cg05347473 chr6:146136440 FBXO30 0.5 6.57 0.37 2.61e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6964587 1.000 rs7785971 chr7:91736794 T/A cg17063962 chr7:91808500 NA 0.54 7.37 0.41 2.16e-12 Breast cancer; CESC cis rs12541635 0.677 rs11781234 chr8:107012342 G/T cg10147462 chr8:107024639 NA 0.48 7.12 0.4 1.03e-11 Age of smoking initiation; CESC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg11663144 chr21:46675770 NA -0.63 -9.96 -0.52 4.72e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs875971 0.660 rs801192 chr7:66031952 C/G cg26939375 chr7:64535504 NA -0.64 -8.8 -0.48 1.77e-16 Aortic root size; CESC cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg05283184 chr6:79620031 NA -0.43 -6.61 -0.38 2.06e-10 Intelligence (multi-trait analysis); CESC cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg21881798 chr11:8931708 C11orf17;ST5 -0.4 -6.46 -0.37 5.08e-10 Hemoglobin concentration; CESC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.93 14.26 0.66 1.22e-34 Prudent dietary pattern; CESC cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.66 6.44 0.37 5.45e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs477895 1.000 rs66968227 chr11:64070930 T/C cg04317338 chr11:64019027 PLCB3 0.69 5.58 0.32 5.98e-8 Mean platelet volume; CESC cis rs72781680 0.898 rs56303870 chr2:24086944 G/A cg20701182 chr2:24300061 SF3B14 0.62 5.66 0.33 3.87e-8 Lymphocyte counts; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04498971 chr17:56084468 SFRS1 -0.47 -6.88 -0.39 4.32e-11 Gambling; CESC cis rs4588572 0.601 rs4305631 chr5:77668698 G/T cg11547950 chr5:77652471 NA 0.45 5.75 0.33 2.48e-8 Triglycerides; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg23260255 chr3:187871479 LPP 0.47 6.2 0.36 2.14e-9 Systemic lupus erythematosus; CESC cis rs11958404 0.932 rs72816541 chr5:157414686 G/A cg05962755 chr5:157440814 NA 0.58 6.53 0.37 3.31e-10 IgG glycosylation; CESC cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -10.6 -0.55 4.22e-22 Chronic sinus infection; CESC cis rs8180040 0.620 rs6414435 chr3:47121140 A/G cg27129171 chr3:47204927 SETD2 0.66 9.71 0.51 2.81e-19 Colorectal cancer; CESC cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg15506890 chr2:3487001 NA -0.48 -6.03 -0.35 5.51e-9 Neurofibrillary tangles; CESC cis rs367943 0.644 rs348942 chr5:112824039 T/C cg12552261 chr5:112820674 MCC -0.64 -8.02 -0.44 3.49e-14 Type 2 diabetes; CESC trans rs7307889 0.793 rs12314345 chr12:6008880 A/G cg18407955 chr7:158110685 PTPRN2 0.72 6.68 0.38 1.41e-10 Obesity-related traits; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg12419862 chr22:24373484 LOC391322 -0.97 -16.27 -0.71 9.59e-42 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs12477438 0.765 rs6722164 chr2:99561527 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -8.75 -0.47 2.6e-16 Chronic sinus infection; CESC cis rs8030485 0.536 rs12595749 chr15:79432359 A/G cg17916960 chr15:79447300 NA 0.31 5.1 0.3 6.41e-7 Left ventricle wall thickness; CESC cis rs2979489 0.591 rs62508371 chr8:30422060 C/T cg26383811 chr8:30366931 RBPMS -0.7 -8.45 -0.46 1.98e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.4 0.32 1.46e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 1.000 rs34193460 chr7:65393110 A/G cg12463550 chr7:65579703 CRCP 0.72 5.53 0.32 7.65e-8 Diabetic kidney disease; CESC cis rs7020830 0.789 rs17408112 chr9:37114065 A/G cg14294708 chr9:37120828 ZCCHC7 1.28 25.68 0.84 7.54e-74 Schizophrenia; CESC cis rs8177253 0.555 rs4481157 chr3:133464684 G/A cg16262614 chr3:133464971 TF 0.29 5.45 0.32 1.14e-7 Iron status biomarkers; CESC cis rs116095464 0.558 rs9687898 chr5:253952 A/G cg10591111 chr5:226296 SDHA -0.51 -6.15 -0.35 2.84e-9 Breast cancer; CESC cis rs35160687 0.623 rs35408390 chr2:86471782 C/T cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.33 -0.31 2.14e-7 Night sleep phenotypes; CESC cis rs3740713 1.000 rs75647856 chr11:18459806 T/C cg23797887 chr11:18477753 LDHAL6A -0.53 -5.11 -0.3 6.1e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs4727963 0.846 rs10953969 chr7:122730629 A/G cg03640110 chr7:122635026 TAS2R16 -0.37 -5.68 -0.33 3.52e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg14393609 chr7:65229607 NA -0.45 -6.13 -0.35 3.17e-9 Aortic root size; CESC cis rs74781061 0.932 rs7161903 chr15:74940270 A/G cg20004910 chr15:75018852 CYP1A1 -0.4 -5.58 -0.32 6.05e-8 Endometriosis; CESC cis rs7582720 1.000 rs72934740 chr2:203741362 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.35 0.41 2.53e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6964587 1.000 rs2282971 chr7:91584356 A/G cg17063962 chr7:91808500 NA 0.53 7.34 0.41 2.66e-12 Breast cancer; CESC cis rs7116495 0.609 rs1541304 chr11:71714078 T/C cg18441811 chr11:71824068 C11orf51 -0.81 -5.36 -0.31 1.85e-7 Severe influenza A (H1N1) infection; CESC cis rs6754311 0.678 rs309181 chr2:136614813 C/G cg07169764 chr2:136633963 MCM6 -0.69 -8.56 -0.47 9.42e-16 Mosquito bite size; CESC trans rs1814175 0.817 rs11040700 chr11:50023832 C/T cg15704280 chr7:45808275 SEPT13 -1.05 -21.18 -0.79 6.15e-59 Height; CESC cis rs10504073 0.647 rs11785310 chr8:50025035 G/A cg00325661 chr8:49890786 NA 0.58 8.62 0.47 6.16e-16 Blood metabolite ratios; CESC cis rs9914988 0.943 rs9913801 chr17:27132105 G/A cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs10751667 0.666 rs7396509 chr11:956761 G/A cg06064525 chr11:970664 AP2A2 -0.48 -9.52 -0.5 1.15e-18 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05462360 chr17:18218585 TOP3A;SMCR8 0.52 6.09 0.35 3.94e-9 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg11764359 chr7:65958608 NA -0.94 -14.76 -0.67 2.09e-36 Aortic root size; CESC trans rs7819412 0.521 rs11777887 chr8:11036799 C/G cg06636001 chr8:8085503 FLJ10661 0.54 6.28 0.36 1.36e-9 Triglycerides; CESC cis rs9814567 0.963 rs9844537 chr3:134238341 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.82 -0.34 1.69e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7474896 0.583 rs1735621 chr10:38167723 G/T cg00409905 chr10:38381863 ZNF37A 0.46 5.1 0.3 6.59e-7 Obesity (extreme); CESC cis rs1784581 0.588 rs9458428 chr6:162424579 A/G cg17173639 chr6:162384350 PARK2 -0.57 -8.8 -0.48 1.86e-16 Itch intensity from mosquito bite; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07052796 chr10:5708731 ASB13 -0.46 -6.38 -0.36 7.77e-10 Gambling; CESC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg04414720 chr1:150670196 GOLPH3L 0.6 8.13 0.45 1.63e-14 Melanoma; CESC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg10074409 chr1:209979377 IRF6 0.4 5.29 0.31 2.59e-7 Cleft lip with or without cleft palate; CESC cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg24920358 chr1:40204285 PPIE 0.42 6.39 0.37 7.54e-10 Blood protein levels; CESC cis rs7769051 0.522 rs3736725 chr6:133095172 A/G cg22852734 chr6:133119734 C6orf192 0.85 7.89 0.44 7.82e-14 Type 2 diabetes nephropathy; CESC cis rs6912958 0.559 rs6921504 chr6:88058972 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.81 0.55 8.16e-23 Monocyte percentage of white cells; CESC cis rs9916302 0.904 rs35285898 chr17:37555872 A/C cg00129232 chr17:37814104 STARD3 0.56 7.35 0.41 2.4e-12 Glomerular filtration rate (creatinine); CESC trans rs9467711 0.606 rs13203358 chr6:26590578 A/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.73 6.0 0.35 6.3e-9 Autism spectrum disorder or schizophrenia; CESC cis rs4268898 0.610 rs72791170 chr2:24449776 C/T cg20701182 chr2:24300061 SF3B14 0.65 6.96 0.39 2.59e-11 Asthma; CESC trans rs921968 0.541 rs576901 chr2:219424364 A/G cg15547669 chr20:2781122 CPXM1 0.35 6.0 0.35 6.51e-9 Mean corpuscular hemoglobin concentration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04789687 chr15:83481869 WHAMM -0.44 -6.13 -0.35 3.22e-9 Gut microbiota (bacterial taxa); CESC cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg02773041 chr1:40204384 PPIE -0.52 -7.36 -0.41 2.28e-12 Blood protein levels; CESC cis rs2742540 0.503 rs2653556 chr11:8906636 C/G cg14711859 chr11:8959438 ASCL3 0.41 6.24 0.36 1.73e-9 Hematocrit; CESC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg14562523 chr21:43528734 C21orf128;UMODL1 0.38 5.57 0.32 6.16e-8 IgG glycosylation; CESC cis rs1371867 0.846 rs1660332 chr8:101309490 A/G cg11906718 chr8:101322791 RNF19A -0.45 -5.79 -0.33 2.04e-8 Atrioventricular conduction; CESC cis rs3096299 1.000 rs3096299 chr16:89448663 G/A cg02187348 chr16:89574699 SPG7 0.52 6.73 0.38 1.04e-10 Multiple myeloma (IgH translocation); CESC cis rs12425791 0.500 rs34336285 chr12:721769 G/T cg01201512 chr12:740338 NINJ2 -0.6 -5.8 -0.34 1.93e-8 Stroke;Paclitaxel disposition in epithelial ovarian cancer; CESC cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg20476274 chr7:133979776 SLC35B4 0.66 9.79 0.52 1.6e-19 Mean platelet volume; CESC cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg03060546 chr3:49711283 APEH 0.45 5.64 0.33 4.42e-8 Parkinson's disease; CESC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.8 6.84 0.39 5.34e-11 Platelet count; CESC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg27535305 chr1:53392650 SCP2 -0.3 -5.29 -0.31 2.6e-7 Monocyte count; CESC cis rs1595825 0.891 rs112898725 chr2:198650006 C/T cg00982548 chr2:198649783 BOLL -0.47 -5.08 -0.3 7.12e-7 Ulcerative colitis; CESC cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg24531977 chr5:56204891 C5orf35 0.7 9.44 0.5 2.05e-18 Initial pursuit acceleration; CESC cis rs9309473 0.583 rs11126397 chr2:73588733 C/T cg20560298 chr2:73613845 ALMS1 -0.5 -6.92 -0.39 3.33e-11 Metabolite levels; CESC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg15445000 chr17:37608096 MED1 -0.4 -6.5 -0.37 3.91e-10 Glomerular filtration rate (creatinine); CESC cis rs4595586 0.525 rs12812749 chr12:39363254 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.23 0.41 5.29e-12 Morning vs. evening chronotype; CESC cis rs9300255 0.639 rs1716171 chr12:123716376 C/T cg00376283 chr12:123451042 ABCB9 0.72 8.89 0.48 9.37e-17 Neutrophil percentage of white cells; CESC cis rs6456156 0.565 rs12525345 chr6:167478875 T/C cg23791538 chr6:167370224 RNASET2 -0.5 -6.44 -0.37 5.46e-10 Primary biliary cholangitis; CESC cis rs2832191 0.935 rs11910316 chr21:30519729 G/A cg24692254 chr21:30365293 RNF160 -0.75 -11.23 -0.57 3.46e-24 Dental caries; CESC cis rs9388451 0.839 rs11154331 chr6:126111429 A/T cg05901451 chr6:126070800 HEY2 -0.61 -8.88 -0.48 1.06e-16 Brugada syndrome; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg01112643 chr6:157802216 ZDHHC14 -0.56 -6.34 -0.36 9.94e-10 Gut microbiota (bacterial taxa); CESC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg05368731 chr17:41323189 NBR1 0.79 10.98 0.56 2.21e-23 Menopause (age at onset); CESC cis rs763121 0.853 rs6001173 chr22:39015302 A/G cg21395723 chr22:39101663 GTPBP1 0.5 6.6 0.38 2.25e-10 Menopause (age at onset); CESC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg03388025 chr16:89894329 SPIRE2 0.42 8.13 0.45 1.65e-14 Vitiligo; CESC cis rs7666738 0.830 rs35531558 chr4:98938217 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9300255 0.568 rs1790108 chr12:123636841 A/G cg00376283 chr12:123451042 ABCB9 0.7 8.88 0.48 1.03e-16 Neutrophil percentage of white cells; CESC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg02463440 chr8:22132932 PIWIL2 0.37 5.66 0.33 3.94e-8 Hypertriglyceridemia; CESC cis rs5417 0.662 rs8067500 chr17:7172631 A/G cg25256661 chr17:7137939 DVL2 0.73 9.21 0.49 9.96e-18 Diastolic blood pressure; CESC cis rs4835473 0.932 rs7667092 chr4:144889757 C/T cg25736465 chr4:144833511 NA 0.41 6.27 0.36 1.43e-9 Immature fraction of reticulocytes; CESC trans rs7246760 1.000 rs7250487 chr19:9886358 T/C cg02900749 chr2:68251473 NA -0.73 -6.82 -0.39 6.17e-11 Pursuit maintenance gain; CESC cis rs4148883 0.603 rs1893883 chr4:100124716 C/G cg13256891 chr4:100009986 ADH5 0.45 6.02 0.35 5.91e-9 Alcohol dependence; CESC cis rs9486715 0.867 rs4839687 chr6:96951732 C/A cg18709589 chr6:96969512 KIAA0776 0.46 6.48 0.37 4.41e-10 Headache; CESC cis rs60843830 0.928 rs2306060 chr2:230912 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.78 9.97 0.52 4.5e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg24296786 chr1:45957014 TESK2 0.63 8.47 0.46 1.74e-15 High light scatter reticulocyte count; CESC cis rs10744422 1.000 rs3852536 chr12:123333824 C/T cg22842854 chr12:123319900 HIP1R -0.61 -5.03 -0.3 9e-7 Schizophrenia; CESC cis rs7712401 0.601 rs246287 chr5:122245426 A/T cg19412675 chr5:122181750 SNX24 0.4 5.03 0.3 8.89e-7 Mean platelet volume; CESC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.47 6.08 0.35 4.23e-9 Tonsillectomy; CESC cis rs8092503 1.000 rs35413162 chr18:52498290 C/G cg12377874 chr18:52495404 RAB27B 0.36 6.07 0.35 4.43e-9 Childhood body mass index; CESC cis rs12142240 0.698 rs1053627 chr1:46827728 A/C cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs7772486 0.875 rs56181683 chr6:146286620 A/G cg05347473 chr6:146136440 FBXO30 -0.5 -6.64 -0.38 1.77e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1949733 1.000 rs868105 chr4:8501030 G/T cg11789530 chr4:8429930 ACOX3 -0.78 -10.97 -0.56 2.51e-23 Response to antineoplastic agents; CESC cis rs4862750 0.872 rs7664463 chr4:187876686 A/C cg10295955 chr4:187884368 NA -1.01 -18.92 -0.76 4.14e-51 Lobe attachment (rater-scored or self-reported); CESC trans rs7618501 0.699 rs6446187 chr3:49907111 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.47 6.59 0.38 2.35e-10 Intelligence (multi-trait analysis); CESC cis rs9858542 1.000 rs9858542 chr3:49701983 A/G cg07274523 chr3:49395745 GPX1 -0.65 -8.39 -0.46 2.94e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9611565 0.918 rs4820438 chr22:41767135 C/T cg03806693 chr22:41940476 POLR3H -0.9 -10.33 -0.54 3.05e-21 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18580865 chr12:93323267 EEA1 0.51 6.06 0.35 4.56e-9 Gut microbiome composition (summer); CESC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg25783544 chr11:47291846 MADD -0.45 -5.1 -0.3 6.57e-7 Subjective well-being; CESC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg18016565 chr1:150552671 MCL1 0.34 5.28 0.31 2.67e-7 Tonsillectomy; CESC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg19622623 chr12:86230825 RASSF9 -0.43 -5.22 -0.31 3.68e-7 Major depressive disorder; CESC cis rs1215050 1.000 rs1215050 chr4:98849826 A/G cg05340658 chr4:99064831 C4orf37 -0.51 -6.1 -0.35 3.77e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7481584 0.564 rs7948848 chr11:2981896 G/A cg08508325 chr11:3079039 CARS 0.33 5.44 0.32 1.24e-7 Calcium levels; CESC cis rs7666738 0.830 rs7664051 chr4:98766970 C/G cg03467027 chr4:99064603 C4orf37 0.42 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg09324608 chr17:30823087 MYO1D 0.45 7.4 0.41 1.76e-12 Schizophrenia; CESC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg04267008 chr7:1944627 MAD1L1 -0.47 -5.58 -0.32 5.82e-8 Schizophrenia; CESC cis rs7937682 1.000 rs2186839 chr11:111534442 T/G cg09085632 chr11:111637200 PPP2R1B -1.02 -16.31 -0.71 6.77e-42 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00094269 chr1:17265567 CROCC -0.57 -7.09 -0.4 1.18e-11 Gut microbiome composition (summer); CESC cis rs7208859 0.524 rs28760584 chr17:29141017 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs1814175 0.615 rs12417290 chr11:49876951 G/A cg03929089 chr4:120376271 NA -0.9 -14.51 -0.67 1.62e-35 Height; CESC cis rs9287719 0.967 rs6748036 chr2:10717489 C/T cg00105475 chr2:10696890 NA 0.39 5.76 0.33 2.34e-8 Prostate cancer; CESC cis rs250677 0.522 rs4705302 chr5:148354962 G/C cg18129178 chr5:148520854 ABLIM3 0.5 5.49 0.32 9.59e-8 Breast cancer; CESC cis rs6582630 0.502 rs4385963 chr12:38295264 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9929218 1.000 rs9936621 chr16:68798682 A/G cg02972257 chr16:68554789 NA 0.43 5.22 0.31 3.65e-7 Colorectal cancer; CESC cis rs12586317 0.586 rs74243591 chr14:35520917 C/T cg16230307 chr14:35515116 FAM177A1 1.13 11.81 0.59 3.79e-26 Psoriasis; CESC cis rs17384381 1.000 rs17384381 chr1:85897570 C/G cg16011679 chr1:85725395 C1orf52 0.7 7.13 0.4 9.3e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg04518342 chr5:131593106 PDLIM4 0.4 6.04 0.35 5.29e-9 Breast cancer; CESC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg18180107 chr4:99064573 C4orf37 0.42 5.46 0.32 1.11e-7 Colonoscopy-negative controls vs population controls; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg17317561 chr3:97663926 MINA 0.46 6.26 0.36 1.55e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2304069 0.545 rs1864998 chr5:149389465 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.48 6.51 0.37 3.82e-10 HIV-1 control; CESC cis rs10129255 0.500 rs10131875 chr14:107201036 T/C cg07958169 chr14:107095056 NA -0.53 -8.18 -0.45 1.23e-14 Kawasaki disease; CESC cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg24209194 chr3:40518798 ZNF619 -0.53 -6.76 -0.38 8.61e-11 Renal cell carcinoma; CESC cis rs7833790 0.929 rs28464834 chr8:82797356 A/T cg17211192 chr8:82754475 SNX16 0.71 8.74 0.47 2.64e-16 Diastolic blood pressure; CESC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg10560079 chr2:191398806 TMEM194B 0.51 7.04 0.4 1.61e-11 Pulse pressure; CESC cis rs7794273 0.963 rs2588637 chr7:18854186 C/T cg13420273 chr7:18810212 HDAC9 0.35 5.2 0.3 3.91e-7 Night sleep phenotypes; CESC cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg25517755 chr10:38738941 LOC399744 -0.48 -6.34 -0.36 9.71e-10 Extrinsic epigenetic age acceleration; CESC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg13770153 chr20:60521292 NA 0.53 6.71 0.38 1.15e-10 Body mass index; CESC cis rs1707322 0.686 rs2991977 chr1:46053683 G/A cg05343316 chr1:45956843 TESK2 -0.55 -6.78 -0.38 7.74e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs734999 0.588 rs6701238 chr1:2520500 G/A cg18854424 chr1:2615690 NA 0.29 5.58 0.32 5.79e-8 Ulcerative colitis; CESC trans rs9325144 0.600 rs10785615 chr12:38733627 G/C cg23762105 chr12:34175262 ALG10 -0.47 -6.35 -0.36 9.35e-10 Morning vs. evening chronotype; CESC cis rs28374715 0.662 rs691906 chr15:41474636 T/A cg18705301 chr15:41695430 NDUFAF1 0.74 9.83 0.52 1.25e-19 Ulcerative colitis; CESC cis rs12464559 0.649 rs4605370 chr2:152628288 C/T cg01189475 chr2:152685088 ARL5A -0.61 -5.45 -0.32 1.17e-7 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg02725872 chr8:58115012 NA -0.34 -5.09 -0.3 6.69e-7 Developmental language disorder (linguistic errors); CESC cis rs35110281 0.627 rs1595167 chr21:44965874 T/G cg01579765 chr21:45077557 HSF2BP -0.51 -8.35 -0.46 3.84e-15 Mean corpuscular volume; CESC trans rs2272205 0.711 rs62226769 chr2:227951253 A/G cg04768315 chr2:1898518 MYT1L 0.74 6.11 0.35 3.56e-9 Immune reponse to smallpox (secreted IFN-alpha); CESC cis rs9399135 0.967 rs9389253 chr6:135329755 T/C cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs2204008 0.744 rs11180504 chr12:38236313 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.1 0.35 3.78e-9 Bladder cancer; CESC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg11890956 chr21:40555474 PSMG1 -0.94 -15.48 -0.69 6.2e-39 Cognitive function; CESC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg12667521 chr19:29218732 NA 0.48 6.4 0.37 6.97e-10 Methadone dose in opioid dependence; CESC cis rs73001065 0.591 rs56273306 chr19:19621004 T/C cg03709012 chr19:19516395 GATAD2A 0.91 6.99 0.39 2.27e-11 LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02294991 chr11:47927148 NA -0.55 -6.74 -0.38 1.01e-10 Gut microbiome composition (summer); CESC cis rs8114671 0.562 rs6087641 chr20:33467717 T/C cg07148914 chr20:33460835 GGT7 0.47 6.3 0.36 1.24e-9 Height; CESC cis rs1670533 1.000 rs10084889 chr4:1053815 G/A cg04106633 chr4:1044584 NA 0.41 5.2 0.3 3.94e-7 Recombination rate (females); CESC cis rs1153858 1.000 rs11070453 chr15:45645154 C/G cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.45e-9 Homoarginine levels; CESC cis rs75477785 1.000 rs12062600 chr1:210051454 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.79 5.15 0.3 5.08e-7 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00775781 chr1:27976168 NA -0.61 -7.31 -0.41 3.19e-12 Gut microbiome composition (summer); CESC cis rs7707921 0.505 rs12516434 chr5:81428072 T/A cg15871215 chr5:81402204 ATG10 0.46 6.43 0.37 6.07e-10 Breast cancer; CESC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.3 0.63 2.89e-31 Prudent dietary pattern; CESC cis rs6433857 0.505 rs16867320 chr2:181362312 A/G cg23363182 chr2:181467187 NA 0.42 5.92 0.34 9.92e-9 Body mass index; CESC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.58 -0.37 2.43e-10 Life satisfaction; CESC cis rs8014204 0.720 rs34752362 chr14:75232306 G/A cg08847533 chr14:75593920 NEK9 0.46 5.85 0.34 1.45e-8 Caffeine consumption; CESC cis rs2439831 0.867 rs45585139 chr15:43700427 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.83 7.8 0.43 1.41e-13 Lung cancer in ever smokers; CESC cis rs3733585 0.773 rs13107466 chr4:10019390 G/A cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.51e-12 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2832191 0.720 rs4643617 chr21:30485278 T/C cg08807101 chr21:30365312 RNF160 -0.77 -11.23 -0.57 3.52e-24 Dental caries; CESC cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg20307385 chr11:47447363 PSMC3 -0.52 -6.29 -0.36 1.32e-9 Subjective well-being; CESC cis rs4727027 0.933 rs10277119 chr7:148849942 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 5.14 0.3 5.42e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7223966 1.000 rs2854218 chr17:61942940 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.47 -5.37 -0.31 1.7e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1110701 0.525 rs11764792 chr7:50496841 C/T cg18232548 chr7:50535776 DDC -0.44 -6.05 -0.35 4.82e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs57221529 0.766 rs17563576 chr5:560476 A/G cg09021430 chr5:549028 NA -0.41 -5.03 -0.3 9.05e-7 Lung disease severity in cystic fibrosis; CESC cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg02551604 chr5:131831745 NA 0.39 5.36 0.31 1.84e-7 Asthma (sex interaction); CESC cis rs7274811 0.744 rs6120316 chr20:32177079 T/C cg21523528 chr20:32077966 CBFA2T2 0.62 7.16 0.4 7.82e-12 Height; CESC cis rs782590 0.537 rs12619903 chr2:55884106 T/A cg18811423 chr2:55921094 PNPT1 -0.6 -7.91 -0.44 6.78e-14 Metabolic syndrome; CESC cis rs6089584 0.526 rs6089316 chr20:60627552 C/T cg24733560 chr20:60626293 TAF4 0.48 7.12 0.4 1e-11 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01123518 chr16:10837605 NUBP1 0.64 7.09 0.4 1.2e-11 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03239638 chr21:37529510 NA -0.52 -6.5 -0.37 4.05e-10 Gut microbiota (bacterial taxa); CESC cis rs67311347 1.000 rs6599102 chr3:40468406 G/A cg24209194 chr3:40518798 ZNF619 0.47 6.12 0.35 3.37e-9 Renal cell carcinoma; CESC cis rs34779708 0.931 rs4934723 chr10:35381763 A/G cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7259376 0.840 rs3862494 chr19:22519522 G/A cg02657401 chr19:22469223 NA -0.26 -5.39 -0.31 1.59e-7 Menopause (age at onset); CESC cis rs1882538 0.512 rs13241734 chr7:133122742 C/G cg10665199 chr7:133106180 EXOC4 0.58 7.83 0.43 1.2e-13 Intelligence (multi-trait analysis); CESC cis rs35110281 0.666 rs2236665 chr21:45108987 C/A cg21573476 chr21:45109991 RRP1B -0.56 -8.12 -0.45 1.77e-14 Mean corpuscular volume; CESC cis rs2228479 0.557 rs34420680 chr16:89809171 C/T cg04013166 chr16:89971882 TCF25 0.76 6.46 0.37 4.94e-10 Skin colour saturation; CESC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7605827 0.930 rs6715487 chr2:15540579 T/C cg19274914 chr2:15703543 NA 0.36 6.4 0.37 7.05e-10 Educational attainment (years of education); CESC cis rs2880765 0.835 rs7169429 chr15:86036648 C/T cg10818794 chr15:86012489 AKAP13 -0.34 -5.24 -0.31 3.23e-7 Coronary artery disease; CESC cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg05347473 chr6:146136440 FBXO30 -0.57 -7.25 -0.41 4.46e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.66 0.33 4e-8 Bipolar disorder; CESC cis rs3126085 0.935 rs10749669 chr1:152177289 A/C cg26876637 chr1:152193138 HRNR -0.46 -5.2 -0.3 3.98e-7 Atopic dermatitis; CESC cis rs7666738 0.830 rs4699577 chr4:98846513 G/A cg17366294 chr4:99064904 C4orf37 0.51 6.98 0.39 2.43e-11 Colonoscopy-negative controls vs population controls; CESC cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg13628971 chr7:2884303 GNA12 0.43 5.77 0.33 2.17e-8 Height; CESC cis rs4073582 0.595 rs9326370 chr11:65992008 A/G cg14036092 chr11:66035641 RAB1B 0.53 7.48 0.42 1.09e-12 Gout; CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg07092213 chr7:1199455 ZFAND2A -0.51 -5.99 -0.35 6.74e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9911578 0.900 rs717828 chr17:56535932 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.41 5.41 0.32 1.38e-7 Intelligence (multi-trait analysis); CESC cis rs1059312 0.545 rs7312683 chr12:129280105 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.42 -5.21 -0.3 3.86e-7 Systemic lupus erythematosus; CESC cis rs2425143 1.000 rs11907811 chr20:34428078 A/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 5.59 0.32 5.54e-8 Blood protein levels; CESC trans rs7615952 0.736 rs11921945 chr3:125643719 A/G cg07211511 chr3:129823064 LOC729375 -1.09 -15.44 -0.69 8.42e-39 Blood pressure (smoking interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12477297 chr1:150336859 RPRD2 -0.47 -6.92 -0.39 3.33e-11 Gambling; CESC cis rs6088590 0.523 rs6059913 chr20:33143288 G/A cg24642439 chr20:33292090 TP53INP2 0.61 8.15 0.45 1.5e-14 Coronary artery disease; CESC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg17971929 chr21:40555470 PSMG1 1.0 13.76 0.65 7.01e-33 Cognitive function; CESC cis rs8067545 0.611 rs12936443 chr17:20033446 T/G cg13482628 chr17:19912719 NA 0.39 5.12 0.3 5.84e-7 Schizophrenia; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg15038082 chr3:184016876 PSMD2 -0.51 -6.22 -0.36 1.89e-9 Gut microbiota (bacterial taxa); CESC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.89e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.24 -0.41 4.79e-12 Developmental language disorder (linguistic errors); CESC cis rs11166629 1.000 rs4909331 chr8:135644540 T/C cg27224718 chr8:135614730 ZFAT 0.5 6.37 0.36 8.2e-10 Smoking quantity; CESC cis rs2243480 0.901 rs778687 chr7:65835819 G/A cg13147721 chr7:65941812 NA -0.95 -8.95 -0.48 6.27e-17 Diabetic kidney disease; CESC cis rs12900413 0.687 rs7176981 chr15:90315757 A/G cg24249390 chr15:90295951 MESP1 -0.41 -5.73 -0.33 2.78e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs2456568 0.835 rs1518578 chr11:93656854 G/T cg26875233 chr11:93583750 C11orf90 -0.32 -5.6 -0.33 5.46e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg24531977 chr5:56204891 C5orf35 -0.88 -11.1 -0.56 9.44e-24 Type 2 diabetes; CESC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg07414643 chr4:187882934 NA 0.52 7.22 0.41 5.6e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09115837 chr10:79541592 NA 0.56 7.49 0.42 1.05e-12 Fibrinogen levels; CESC cis rs1691799 0.867 rs1168332 chr12:66761548 C/T cg16791601 chr12:66731901 HELB -0.76 -13.16 -0.63 8.86e-31 White blood cell count (basophil); CESC cis rs721399 0.553 rs13282367 chr8:18244986 T/G cg18736775 chr8:18248649 NAT2 -0.56 -5.7 -0.33 3.17e-8 Blood metabolite levels; CESC cis rs3015497 0.603 rs3015451 chr14:51071091 C/A cg26011998 chr14:51135199 SAV1 -0.46 -5.22 -0.31 3.6e-7 Mean platelet volume; CESC cis rs854765 0.604 rs12948749 chr17:17949802 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.46 -5.95 -0.34 8.3e-9 Total body bone mineral density; CESC cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg23463467 chr20:60627584 TAF4 0.34 5.08 0.3 7.18e-7 Body mass index; CESC cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg25019033 chr10:957182 NA -0.56 -6.07 -0.35 4.48e-9 Eosinophil percentage of granulocytes; CESC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg19592336 chr6:28129416 ZNF389 0.61 8.24 0.45 8.13e-15 Depression; CESC cis rs61931739 0.500 rs3922568 chr12:34560107 A/C cg06521331 chr12:34319734 NA -0.36 -5.04 -0.3 8.47e-7 Morning vs. evening chronotype; CESC cis rs2282802 0.685 rs2053055 chr5:139646776 C/T cg26211634 chr5:139558579 C5orf32 0.52 7.59 0.42 5.57e-13 Intelligence (multi-trait analysis); CESC cis rs5753618 0.509 rs2413033 chr22:31574213 A/G cg13145458 chr22:31556086 RNF185 0.45 5.05 0.3 8.06e-7 Colorectal cancer; CESC cis rs372883 0.613 rs1153274 chr21:30660026 T/C cg08807101 chr21:30365312 RNF160 -0.46 -5.52 -0.32 8.03e-8 Pancreatic cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27465384 chr16:1435426 NA 0.46 6.28 0.36 1.39e-9 Fibrinogen levels; CESC cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10791097 0.702 rs10894267 chr11:130714861 C/T cg14779329 chr11:130786720 SNX19 -0.34 -5.07 -0.3 7.56e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg07636037 chr3:49044803 WDR6 1.06 19.21 0.76 3.89e-52 Parkinson's disease; CESC cis rs34779708 0.966 rs17591781 chr10:35498538 G/A cg04310649 chr10:35416472 CREM -0.52 -6.33 -0.36 1.06e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs72781680 0.898 rs10490751 chr2:24001356 A/G cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.64 0.47 5.23e-16 Menopause (age at onset); CESC cis rs7100689 0.784 rs10749562 chr10:82108253 G/T cg00277334 chr10:82204260 NA -0.6 -7.66 -0.43 3.42e-13 Post bronchodilator FEV1; CESC cis rs2235642 0.787 rs2235646 chr16:1601287 A/G cg03771183 chr16:1608904 IFT140 0.41 5.94 0.34 8.79e-9 Coronary artery disease; CESC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg07636037 chr3:49044803 WDR6 1.06 19.29 0.76 2.09e-52 Parkinson's disease; CESC cis rs4819052 0.959 rs9976074 chr21:46655638 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.58 6.77 0.38 8.26e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.800 rs10008654 chr4:98820498 C/A cg05340658 chr4:99064831 C4orf37 0.73 10.49 0.54 9.13e-22 Colonoscopy-negative controls vs population controls; CESC cis rs911555 0.723 rs12894652 chr14:103926024 A/G cg24130564 chr14:104152367 KLC1 0.49 6.22 0.36 1.95e-9 Intelligence (multi-trait analysis); CESC cis rs916888 0.821 rs199504 chr17:44861003 C/T cg17911788 chr17:44343683 NA 0.55 7.29 0.41 3.68e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9403521 1.000 rs117303301 chr6:143999003 C/T cg21026257 chr6:143998961 PHACTR2 0.46 5.03 0.3 8.98e-7 Obesity-related traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11738299 chr1:112282125 C1orf183 -0.43 -6.11 -0.35 3.6e-9 Gambling; CESC cis rs4141404 0.818 rs6518737 chr22:31582662 A/G cg13145458 chr22:31556086 RNF185 0.49 6.14 0.35 2.99e-9 Paclitaxel-induced neuropathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23206777 chr17:66031448 KPNA2 -0.51 -6.09 -0.35 4.05e-9 Gut microbiome composition (summer); CESC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg22903657 chr4:1355424 KIAA1530 -0.38 -5.18 -0.3 4.5e-7 Obesity-related traits; CESC cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.56 0.47 9.09e-16 Colonoscopy-negative controls vs population controls; CESC cis rs10463316 0.817 rs2112419 chr5:150797804 T/C cg03212797 chr5:150827313 SLC36A1 -0.51 -6.68 -0.38 1.43e-10 Metabolite levels (Pyroglutamine); CESC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg04369109 chr6:150039330 LATS1 -0.37 -5.19 -0.3 4.24e-7 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18517677 chr9:131799243 FAM73B 0.6 6.85 0.39 5.11e-11 Gut microbiome composition (summer); CESC cis rs9314323 0.767 rs13271042 chr8:26190212 T/G cg11498726 chr8:26250323 BNIP3L -0.49 -6.78 -0.38 7.75e-11 Red cell distribution width; CESC cis rs11098499 0.644 rs34835603 chr4:120553428 C/T cg24375607 chr4:120327624 NA 0.41 5.18 0.3 4.4e-7 Corneal astigmatism; CESC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg09359103 chr1:154839909 KCNN3 -0.65 -12.19 -0.6 1.91e-27 Prostate cancer; CESC cis rs300703 0.542 rs300697 chr2:184496 C/T cg21211680 chr2:198530 NA -0.85 -9.2 -0.49 1.08e-17 Blood protein levels; CESC cis rs367943 0.626 rs7718480 chr5:112704486 G/T cg12552261 chr5:112820674 MCC 0.42 5.53 0.32 7.73e-8 Type 2 diabetes; CESC cis rs8028182 0.636 rs28432989 chr15:75768297 T/C cg20655648 chr15:75932815 IMP3 0.47 5.89 0.34 1.19e-8 Sudden cardiac arrest; CESC cis rs910316 1.000 rs4903279 chr14:75546583 C/T cg08847533 chr14:75593920 NEK9 0.99 18.86 0.76 6.94e-51 Height; CESC cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg24112000 chr20:60950667 NA -0.47 -5.89 -0.34 1.15e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs3820068 0.581 rs68052904 chr1:15916714 T/C cg17385448 chr1:15911702 AGMAT 0.45 7.19 0.4 6.53e-12 Systolic blood pressure; CESC cis rs2439831 0.850 rs16963953 chr15:44081719 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.78 0.43 1.66e-13 Lung cancer in ever smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03749393 chr13:31191824 USPL1 -0.55 -6.14 -0.35 2.96e-9 Gut microbiome composition (summer); CESC cis rs2625529 0.586 rs7170456 chr15:72469946 G/C cg16672083 chr15:72433130 SENP8 0.5 7.49 0.42 1.02e-12 Red blood cell count; CESC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg07870213 chr5:140052090 DND1 0.63 6.87 0.39 4.59e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04254320 chr11:16628010 NA -0.54 -6.4 -0.37 6.85e-10 Gut microbiome composition (summer); CESC cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg10057126 chr4:77819792 ANKRD56 -0.57 -8.24 -0.45 7.96e-15 Emphysema distribution in smoking; CESC cis rs7647973 0.580 rs4955432 chr3:49266772 C/T cg06212747 chr3:49208901 KLHDC8B 0.7 10.4 0.54 1.76e-21 Menarche (age at onset); CESC cis rs7666738 0.546 rs13148080 chr4:98680947 A/G cg05340658 chr4:99064831 C4orf37 0.55 6.6 0.38 2.24e-10 Colonoscopy-negative controls vs population controls; CESC cis rs796364 0.789 rs176008 chr2:200814720 A/T cg23649088 chr2:200775458 C2orf69 0.54 5.09 0.3 6.71e-7 Schizophrenia; CESC cis rs6500395 1.000 rs9922734 chr16:48603192 A/G cg04672837 chr16:48644449 N4BP1 -0.49 -6.25 -0.36 1.6e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4803468 1.000 rs284658 chr19:41929988 G/A cg09537434 chr19:41945824 ATP5SL -1.04 -18.76 -0.76 1.48e-50 Height; CESC cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg03060546 chr3:49711283 APEH 0.5 6.16 0.35 2.75e-9 Parkinson's disease; CESC cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg05340658 chr4:99064831 C4orf37 0.79 12.12 0.6 3.52e-27 Colonoscopy-negative controls vs population controls; CESC cis rs62344088 0.590 rs6889904 chr5:177264 A/C cg22857025 chr5:266934 NA -1.11 -8.88 -0.48 1.01e-16 Asthma (childhood onset); CESC cis rs854765 0.547 rs2955385 chr17:17939247 C/T cg09796270 chr17:17721594 SREBF1 0.38 5.19 0.3 4.11e-7 Total body bone mineral density; CESC cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg25019033 chr10:957182 NA -0.56 -5.57 -0.32 6.34e-8 Eosinophil percentage of granulocytes; CESC cis rs7216064 1.000 rs2046323 chr17:65849927 T/G cg12091567 chr17:66097778 LOC651250 -0.85 -8.69 -0.47 3.85e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4253772 0.530 rs11704350 chr22:46671507 C/T cg18190219 chr22:46762943 CELSR1 -0.59 -5.7 -0.33 3.26e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.49 7.21 0.41 5.7e-12 Total body bone mineral density; CESC cis rs8180040 0.932 rs1531875 chr3:47452786 G/A cg27129171 chr3:47204927 SETD2 0.64 9.67 0.51 3.73e-19 Colorectal cancer; CESC cis rs11608355 0.597 rs9943699 chr12:109840876 G/C cg19025524 chr12:109796872 NA -0.52 -7.25 -0.41 4.65e-12 Neuroticism; CESC cis rs12477438 0.798 rs10198293 chr2:99602929 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg15012766 chr1:41832369 NA 0.42 6.17 0.35 2.56e-9 Post-traumatic stress disorder; CESC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg18252515 chr7:66147081 NA 0.45 5.88 0.34 1.22e-8 Aortic root size; CESC cis rs72634258 0.519 rs35267144 chr1:7934258 G/A cg00042356 chr1:8021962 PARK7 0.54 5.58 0.32 5.79e-8 Inflammatory bowel disease; CESC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.51 6.97 0.39 2.51e-11 Lymphocyte counts; CESC cis rs506597 0.920 rs2432929 chr7:100299028 C/T cg10426581 chr7:100472382 SRRT -0.67 -5.21 -0.3 3.81e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs1509123 0.609 rs114532955 chr17:6728700 G/A cg12642237 chr17:6703447 TEKT1 -0.64 -5.26 -0.31 2.94e-7 Blood metabolite levels; CESC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC trans rs10953454 1.000 rs10243336 chr7:104494560 C/A cg04245439 chr3:142607978 PCOLCE2 -0.76 -6.14 -0.35 2.96e-9 Obesity; CESC cis rs1847202 0.826 rs11922892 chr3:72952186 T/G cg25664220 chr3:72788482 NA -0.39 -5.67 -0.33 3.68e-8 Motion sickness; CESC cis rs4974559 1.000 rs10006789 chr4:1330333 T/C cg02980000 chr4:1222292 CTBP1 0.64 7.35 0.41 2.43e-12 Systolic blood pressure; CESC cis rs7647973 0.769 rs11130181 chr3:49109919 G/A cg07636037 chr3:49044803 WDR6 0.89 13.08 0.63 1.67e-30 Menarche (age at onset); CESC cis rs7666738 0.830 rs13121766 chr4:98935766 A/C cg17366294 chr4:99064904 C4orf37 0.59 8.32 0.46 4.7e-15 Colonoscopy-negative controls vs population controls; CESC cis rs782590 0.643 rs13032503 chr2:55739093 C/T cg18811423 chr2:55921094 PNPT1 -0.57 -7.77 -0.43 1.7e-13 Metabolic syndrome; CESC cis rs2708240 1.000 rs2247149 chr7:147581161 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.55 -0.32 7.07e-8 QT interval (drug interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05827346 chr20:48732560 UBE2V1;TMEM189-UBE2V1 0.58 6.5 0.37 3.9e-10 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg11890956 chr21:40555474 PSMG1 0.69 9.5 0.5 1.31e-18 Cognitive function; CESC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg01341218 chr17:43662625 NA -0.87 -10.56 -0.54 5.35e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg04267008 chr7:1944627 MAD1L1 -0.71 -9.18 -0.49 1.24e-17 Bipolar disorder and schizophrenia; CESC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg02569458 chr12:86230093 RASSF9 0.51 7.69 0.43 2.85e-13 Major depressive disorder; CESC cis rs2243480 1.000 rs313809 chr7:65499983 G/A cg25894440 chr7:65020034 NA -0.68 -5.84 -0.34 1.51e-8 Diabetic kidney disease; CESC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg04414720 chr1:150670196 GOLPH3L -0.48 -6.07 -0.35 4.43e-9 Blood protein levels; CESC cis rs9486719 0.843 rs2499789 chr6:96844510 T/C cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC cis rs2315504 0.626 rs2469823 chr17:39006842 A/G cg05063374 chr17:38953512 KRT28 0.38 5.27 0.31 2.84e-7 Height; CESC cis rs6460942 1.000 rs73053527 chr7:12313008 C/A cg02935154 chr7:12443704 VWDE -0.59 -5.84 -0.34 1.5e-8 Coronary artery disease; CESC cis rs2066819 1.000 rs2695782 chr12:56722830 C/T cg26316697 chr12:56727976 PAN2 -0.67 -5.87 -0.34 1.32e-8 Psoriasis vulgaris; CESC cis rs2463822 0.925 rs1881535 chr11:62121623 C/T cg06239285 chr11:62104954 ASRGL1 0.86 8.63 0.47 5.79e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg24154853 chr7:158122151 PTPRN2 0.43 6.78 0.38 7.65e-11 Calcium levels; CESC cis rs3026101 0.671 rs2407 chr17:5289028 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.38 5.16 0.3 4.87e-7 Body mass index; CESC trans rs1908814 0.541 rs7824267 chr8:11794279 G/T cg15556689 chr8:8085844 FLJ10661 0.51 6.32 0.36 1.1e-9 Neuroticism; CESC cis rs2076222 1.000 rs2076349 chr1:209800230 C/T cg00257659 chr1:209800214 LAMB3 -0.87 -7.95 -0.44 5.49e-14 Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours); CESC cis rs2236918 1.000 rs2995544 chr1:242020495 C/T cg17736920 chr1:242011382 EXO1 0.72 9.08 0.49 2.55e-17 Menopause (age at onset); CESC cis rs7772486 0.790 rs9497425 chr6:146234197 G/A cg05347473 chr6:146136440 FBXO30 -0.53 -6.92 -0.39 3.46e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs2455799 0.613 rs1393969 chr3:15730257 G/A cg16303742 chr3:15540471 COLQ -0.38 -5.8 -0.34 1.87e-8 Mean platelet volume; CESC cis rs3741151 0.773 rs73544711 chr11:73164870 T/A cg17517138 chr11:73019481 ARHGEF17 1.0 7.41 0.41 1.74e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs769267 0.864 rs7245983 chr19:19657632 A/C cg03709012 chr19:19516395 GATAD2A 1.0 15.2 0.68 5.96e-38 Tonsillectomy; CESC cis rs9910055 0.573 rs228768 chr17:42191893 A/C cg08499158 chr17:42289980 UBTF -0.45 -5.61 -0.33 5.19e-8 Total body bone mineral density; CESC trans rs7618501 1.000 rs6775384 chr3:49853073 G/A cg21659725 chr3:3221576 CRBN 0.81 12.97 0.62 4.11e-30 Intelligence (multi-trait analysis); CESC cis rs10129255 0.500 rs9324092 chr14:107139823 A/G cg23076370 chr14:107095027 NA 0.69 10.54 0.54 6.39e-22 Kawasaki disease; CESC cis rs12819124 0.502 rs10875718 chr12:48411102 G/T cg04545296 chr12:48745243 ZNF641 0.34 5.78 0.33 2.15e-8 Glycated hemoglobin levels; CESC cis rs7267979 1.000 rs2424710 chr20:25283886 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.86 16.82 0.72 1.06e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs2404602 0.692 rs4886503 chr15:77108874 C/T cg22467129 chr15:76604101 ETFA 0.36 5.39 0.31 1.56e-7 Blood metabolite levels; CESC cis rs2180341 0.695 rs6569487 chr6:127726196 C/T cg24812749 chr6:127587940 RNF146 -0.74 -10.77 -0.55 1.13e-22 Breast cancer; CESC cis rs4253772 0.678 rs1053332 chr22:46640179 A/G cg09491104 chr22:46646882 C22orf40 -0.57 -8.75 -0.47 2.46e-16 LDL cholesterol;Cholesterol, total; CESC trans rs2814021 0.653 rs2787697 chr10:63296825 T/A cg08188886 chr14:105633697 JAG2 -0.42 -6.1 -0.35 3.73e-9 Obesity-related traits; CESC cis rs290268 0.817 rs291006 chr9:93540244 A/C cg02608019 chr9:93564028 SYK 0.57 8.38 0.46 3.05e-15 Platelet count; CESC cis rs6460942 0.591 rs62448727 chr7:12332362 G/C cg02935154 chr7:12443704 VWDE -0.53 -5.5 -0.32 9.01e-8 Coronary artery disease; CESC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.99 9.32 0.5 4.59e-18 Platelet count; CESC cis rs9902453 0.904 rs9900974 chr17:28364456 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.69 -0.47 3.84e-16 Coffee consumption (cups per day); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02237855 chr2:74329332 TET3 0.5 6.68 0.38 1.42e-10 Fibrinogen levels; CESC cis rs12545109 0.800 rs1996106 chr8:57412963 A/G cg09654669 chr8:57350985 NA -0.46 -6.28 -0.36 1.4e-9 Obesity-related traits; CESC cis rs9457247 0.534 rs9347170 chr6:167405187 C/T cg25258033 chr6:167368657 RNASET2 -0.35 -5.12 -0.3 6.01e-7 Crohn's disease; CESC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg26587870 chr6:27730563 NA -0.58 -5.08 -0.3 7.2e-7 Depression; CESC cis rs9486719 1.000 rs13208422 chr6:96892119 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs6582630 0.555 rs2197308 chr12:38281261 A/G cg26384229 chr12:38710491 ALG10B -0.43 -5.6 -0.33 5.46e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs67311347 1.000 rs11707278 chr3:40487075 A/T cg09455208 chr3:40491958 NA 0.49 8.1 0.45 2.06e-14 Renal cell carcinoma; CESC trans rs4904167 0.841 rs12587485 chr14:84685194 A/G cg06870609 chr15:89787223 FANCI 0.46 6.01 0.35 6.03e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7945705 0.902 rs10743093 chr11:8869129 A/G cg12365402 chr11:9010492 NRIP3 0.36 5.5 0.32 8.77e-8 Hemoglobin concentration; CESC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs77741769 0.571 rs3809313 chr12:121329967 T/C cg02419362 chr12:121203948 SPPL3 0.34 5.57 0.32 6.38e-8 Mean corpuscular volume; CESC cis rs9419702 0.639 rs9419624 chr10:133534822 G/A cg04492858 chr10:133558786 NA 0.39 5.52 0.32 7.87e-8 Survival in rectal cancer; CESC cis rs863345 0.604 rs2023632 chr1:158459034 T/C cg12129480 chr1:158549410 OR10X1 -0.36 -7.15 -0.4 8.67e-12 Pneumococcal bacteremia; CESC cis rs12220238 1.000 rs10824113 chr10:75969018 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.44 0.32 1.24e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg27266027 chr21:40555129 PSMG1 0.45 5.29 0.31 2.5e-7 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26976744 chr8:120845108 TAF2 0.58 6.13 0.35 3.13e-9 Gut microbiome composition (summer); CESC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg22433210 chr17:43662623 NA -0.88 -10.59 -0.55 4.45e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs16854884 0.632 rs59287916 chr3:143638337 G/A cg06585982 chr3:143692056 C3orf58 0.53 6.95 0.39 2.87e-11 Economic and political preferences (feminism/equality); CESC trans rs1728785 1.000 rs7202306 chr16:68587684 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.64 7.76 0.43 1.89e-13 Ulcerative colitis; CESC cis rs854765 0.547 rs9913277 chr17:17919749 G/T cg09796270 chr17:17721594 SREBF1 0.38 5.3 0.31 2.43e-7 Total body bone mineral density; CESC cis rs4718428 0.705 rs10267335 chr7:66403220 G/T cg12165864 chr7:66369176 NA -0.67 -7.73 -0.43 2.18e-13 Corneal structure; CESC cis rs1153858 1.000 rs59889118 chr15:45618730 G/A cg14582100 chr15:45693742 SPATA5L1 0.41 5.71 0.33 3.06e-8 Homoarginine levels; CESC cis rs7267979 0.844 rs1555330 chr20:25232097 A/C cg08601574 chr20:25228251 PYGB 0.42 5.81 0.34 1.82e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7527798 0.592 rs6702222 chr1:207825627 C/T cg21110645 chr1:207815933 NA -0.33 -5.88 -0.34 1.21e-8 Erythrocyte sedimentation rate; CESC cis rs4889855 0.556 rs11150863 chr17:78532321 A/G cg16591659 chr17:78472290 NA -0.33 -5.47 -0.32 1.05e-7 Fractional excretion of uric acid; CESC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg26587870 chr6:27730563 NA 0.57 5.35 0.31 1.87e-7 Depression; CESC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg17376030 chr22:41985996 PMM1 0.79 8.34 0.46 4.03e-15 Vitiligo; CESC cis rs7336332 0.598 rs77055070 chr13:28010516 C/G cg22138327 chr13:27999177 GTF3A 0.62 5.82 0.34 1.71e-8 Weight; CESC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg13206674 chr6:150067644 NUP43 0.43 6.3 0.36 1.27e-9 Lung cancer; CESC cis rs36051895 0.632 rs7850484 chr9:5147817 C/T cg02405213 chr9:5042618 JAK2 -0.45 -5.44 -0.32 1.23e-7 Pediatric autoimmune diseases; CESC cis rs950776 0.518 rs12907169 chr15:78825498 G/C cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs2932538 0.922 rs9429694 chr1:113158289 G/A cg22162597 chr1:113214053 CAPZA1 0.59 7.44 0.42 1.39e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs3105593 1.000 rs3131590 chr15:50840955 G/T cg08437265 chr15:50716283 USP8 0.43 5.66 0.33 4.02e-8 QT interval; CESC cis rs1348850 0.558 rs4337505 chr2:178529714 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 6.71 0.38 1.2e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7615952 0.609 rs13088451 chr3:125553499 G/C cg05084668 chr3:125655381 ALG1L -0.46 -5.3 -0.31 2.42e-7 Blood pressure (smoking interaction); CESC cis rs748404 0.660 rs509306 chr15:43715171 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.57 0.42 6.3e-13 Lung cancer; CESC cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.22e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8016982 0.698 rs12590764 chr14:81704417 G/A cg01989461 chr14:81687754 GTF2A1 0.68 10.36 0.54 2.42e-21 Schizophrenia; CESC trans rs35740288 0.822 rs17574774 chr15:86233370 C/T cg11485152 chr3:3171664 TRNT1 0.46 6.16 0.35 2.74e-9 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs10504229 0.593 rs11781042 chr8:57993056 A/T cg24829409 chr8:58192753 C8orf71 -0.49 -5.88 -0.34 1.21e-8 Developmental language disorder (linguistic errors); CESC cis rs977987 0.736 rs4888392 chr16:75412262 T/C cg03315344 chr16:75512273 CHST6 0.4 5.74 0.33 2.65e-8 Dupuytren's disease; CESC cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg20503657 chr10:835505 NA 0.7 6.12 0.35 3.35e-9 Eosinophil percentage of granulocytes; CESC cis rs78487399 0.519 rs11124929 chr2:43582103 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.55 -5.08 -0.3 7.16e-7 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; CESC cis rs3820928 0.874 rs10183633 chr2:227887828 A/G cg05526886 chr2:227700861 RHBDD1 -0.43 -5.49 -0.32 9.36e-8 Pulmonary function; CESC cis rs2204008 0.606 rs1581358 chr12:38391582 G/T cg26384229 chr12:38710491 ALG10B 0.72 10.14 0.53 1.29e-20 Bladder cancer; CESC cis rs9549260 0.683 rs4941988 chr13:41196006 T/G cg21288729 chr13:41239152 FOXO1 0.62 7.9 0.44 7.34e-14 Red blood cell count; CESC cis rs1371867 0.846 rs1616833 chr8:101271821 C/T cg11906718 chr8:101322791 RNF19A -0.42 -5.38 -0.31 1.67e-7 Atrioventricular conduction; CESC cis rs7714584 1.000 rs7734928 chr5:150256613 G/A cg22134413 chr5:150180641 NA 0.51 5.92 0.34 9.88e-9 Crohn's disease; CESC cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg06544989 chr22:39130855 UNC84B 0.52 9.08 0.49 2.57e-17 Menopause (age at onset); CESC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg12437481 chr16:420112 MRPL28 -0.51 -6.71 -0.38 1.2e-10 Bone mineral density (spine);Bone mineral density; CESC cis rs8072100 0.875 rs7208530 chr17:45544107 C/T cg08085267 chr17:45401833 C17orf57 -0.56 -7.43 -0.42 1.51e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1153858 1.000 rs3809472 chr15:45694318 G/T cg14582100 chr15:45693742 SPATA5L1 0.42 5.88 0.34 1.22e-8 Homoarginine levels; CESC cis rs708547 0.647 rs4864609 chr4:57878141 T/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -5.58 -0.32 6.06e-8 Response to bleomycin (chromatid breaks); CESC cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg05340658 chr4:99064831 C4orf37 0.65 8.07 0.44 2.45e-14 Colonoscopy-negative controls vs population controls; CESC cis rs1215050 0.765 rs1588018 chr4:98756324 G/C cg05340658 chr4:99064831 C4orf37 0.5 6.45 0.37 5.14e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs60871478 0.579 rs56109762 chr7:925967 G/A cg27478167 chr7:817139 HEATR2 0.57 5.38 0.31 1.62e-7 Cerebrospinal P-tau181p levels; CESC cis rs6121246 0.909 rs2376992 chr20:30263418 T/C cg13852791 chr20:30311386 BCL2L1 0.77 8.18 0.45 1.17e-14 Mean corpuscular hemoglobin; CESC cis rs208520 0.690 rs4618506 chr6:66756889 A/C cg07460842 chr6:66804631 NA -0.89 -11.71 -0.58 8.53e-26 Exhaled nitric oxide output; CESC cis rs11098499 0.913 rs35271032 chr4:120156659 C/T cg24375607 chr4:120327624 NA 0.43 5.15 0.3 5.05e-7 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08578505 chr19:45582924 GEMIN7 -0.54 -6.26 -0.36 1.5e-9 Gut microbiome composition (summer); CESC cis rs796364 0.901 rs13030683 chr2:201061535 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.59 5.87 0.34 1.31e-8 Schizophrenia; CESC cis rs9814567 1.000 rs9864346 chr3:134312352 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.71 -0.33 2.97e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.95 0.34 8.67e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7084402 0.967 rs1649019 chr10:60288111 T/C cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs9790314 0.846 rs1478568 chr3:161014276 C/T cg03342759 chr3:160939853 NMD3 -0.45 -6.15 -0.35 2.89e-9 Morning vs. evening chronotype; CESC cis rs6460942 0.505 rs73055515 chr7:12328804 A/G cg06484146 chr7:12443880 VWDE -0.62 -6.38 -0.36 7.88e-10 Coronary artery disease; CESC cis rs854765 0.583 rs9635697 chr17:17870394 T/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.06 0.4 1.45e-11 Total body bone mineral density; CESC cis rs1728785 1.000 rs12918861 chr16:68566508 G/A cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC trans rs7819412 0.715 rs2409727 chr8:11043236 C/T cg15556689 chr8:8085844 FLJ10661 -0.54 -6.54 -0.37 3.16e-10 Triglycerides; CESC cis rs57244997 0.725 rs73028490 chr6:162421657 T/C cg17173639 chr6:162384350 PARK2 -0.53 -5.66 -0.33 3.91e-8 Mosquito bite size; CESC cis rs9300255 0.596 rs10732573 chr12:123743883 G/C cg05973401 chr12:123451056 ABCB9 0.44 5.37 0.31 1.76e-7 Neutrophil percentage of white cells; CESC cis rs10754283 0.934 rs10754284 chr1:90113702 A/C cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs34779708 0.658 rs4934715 chr10:35364992 G/T cg04310649 chr10:35416472 CREM -0.54 -6.47 -0.37 4.63e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs56775891 0.959 rs7238071 chr18:77579812 C/T cg13263691 chr18:77568018 NA -0.47 -6.95 -0.39 2.92e-11 Schizophrenia; CESC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg00106254 chr7:1943704 MAD1L1 -0.46 -5.7 -0.33 3.24e-8 Bipolar disorder and schizophrenia; CESC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg18404041 chr3:52824283 ITIH1 0.42 6.96 0.39 2.71e-11 Bipolar disorder; CESC cis rs3767633 0.858 rs4300199 chr1:161852057 A/G cg09175582 chr1:161736000 ATF6 0.86 6.95 0.39 2.83e-11 IgG glycosylation; CESC cis rs4563143 0.514 rs73029076 chr19:29292032 G/T cg12756686 chr19:29218302 NA 0.54 6.3 0.36 1.22e-9 Methadone dose in opioid dependence; CESC cis rs2243480 1.000 rs6958289 chr7:65657111 T/G cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.24e-32 Diabetic kidney disease; CESC cis rs13082711 0.554 rs66854845 chr3:27387008 C/T cg02860705 chr3:27208620 NA 0.77 8.66 0.47 4.61e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg12386194 chr3:101231763 SENP7 0.57 6.05 0.35 4.88e-9 Colonoscopy-negative controls vs population controls; CESC cis rs870825 0.616 rs7682677 chr4:185640717 C/G cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.17e-9 Menopause (age at onset); CESC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg27170947 chr2:26402098 FAM59B -0.61 -7.15 -0.4 8.53e-12 Gut microbiome composition (summer); CESC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg21984481 chr17:79567631 NPLOC4 -0.34 -5.2 -0.3 4.08e-7 Eye color traits; CESC cis rs1568889 1.000 rs66702115 chr11:28181703 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.81 0.55 8.6e-23 Bipolar disorder; CESC cis rs35306767 0.953 rs12259801 chr10:959306 C/G cg25019033 chr10:957182 NA -0.65 -7.87 -0.44 8.8e-14 Eosinophil percentage of granulocytes; CESC cis rs2235649 0.798 rs4100646 chr16:1850446 C/T cg03715980 chr16:1756201 MAPK8IP3 0.43 5.5 0.32 8.95e-8 Blood metabolite levels; CESC cis rs7336332 0.800 rs9805452 chr13:28047908 C/T cg22138327 chr13:27999177 GTF3A 0.56 6.37 0.36 8.14e-10 Weight; CESC cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg21518248 chr2:162101506 NA 0.47 6.37 0.36 8.38e-10 Intelligence (multi-trait analysis); CESC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg07701084 chr6:150067640 NUP43 0.46 6.45 0.37 5.26e-10 Lung cancer; CESC cis rs7818688 0.674 rs74632106 chr8:95978032 A/G cg16049864 chr8:95962084 TP53INP1 0.57 5.73 0.33 2.79e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs116095464 0.558 rs13354585 chr5:242263 G/C cg22857025 chr5:266934 NA -1.27 -18.21 -0.75 1.27e-48 Breast cancer; CESC cis rs651907 0.535 rs11919389 chr3:101424458 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.9 0.34 1.1e-8 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14001360 chr2:28113654 BRE;LOC100302650;RBKS 0.62 7.19 0.4 6.71e-12 Gut microbiome composition (summer); CESC trans rs4824093 0.610 rs60036544 chr22:50264019 C/T cg09872104 chr7:134855509 C7orf49 -0.97 -6.92 -0.39 3.45e-11 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7116495 0.881 rs7128974 chr11:71677032 C/G cg10381502 chr11:71823885 C11orf51 0.67 5.48 0.32 9.83e-8 Severe influenza A (H1N1) infection; CESC cis rs7044106 0.762 rs966397 chr9:123453312 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 12.82 0.62 1.3e-29 Hip circumference adjusted for BMI; CESC trans rs7618501 1.000 rs6775384 chr3:49853073 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.56 7.96 0.44 4.91e-14 Intelligence (multi-trait analysis); CESC cis rs854765 0.583 rs4553680 chr17:17857722 A/G cg09796270 chr17:17721594 SREBF1 0.48 6.53 0.37 3.37e-10 Total body bone mineral density; CESC cis rs2115536 1.000 rs11072871 chr15:80197931 T/C cg11839771 chr15:80205821 ST20 -0.41 -5.89 -0.34 1.19e-8 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg05347473 chr6:146136440 FBXO30 0.59 7.78 0.43 1.59e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7771547 0.573 rs9470274 chr6:36397229 G/A cg04289385 chr6:36355825 ETV7 0.38 5.57 0.32 6.41e-8 Platelet distribution width; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19729279 chr5:133861951 PHF15 -0.44 -6.18 -0.35 2.36e-9 Gambling; CESC cis rs1801251 0.711 rs2592117 chr2:233735693 C/T cg25237894 chr2:233734115 C2orf82 -0.5 -8.76 -0.47 2.34e-16 Coronary artery disease; CESC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg23758822 chr17:41437982 NA 1.02 15.58 0.69 2.64e-39 Menopause (age at onset); CESC cis rs9303401 0.614 rs12950028 chr17:56510140 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.96 12.09 0.6 4.46e-27 Cognitive test performance; CESC cis rs870825 0.616 rs28444118 chr4:185621692 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs644799 1.000 rs481630 chr11:95582447 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.57 0.47 8.62e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9549367 0.664 rs9549689 chr13:113848387 G/A cg00898013 chr13:113819073 PROZ -0.55 -7.46 -0.42 1.24e-12 Platelet distribution width; CESC trans rs4942242 1.000 rs4942242 chr13:44217064 A/G cg19169023 chr15:41853346 TYRO3 0.43 6.1 0.35 3.64e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs13385 0.769 rs7707814 chr5:139583728 C/G cg26211634 chr5:139558579 C5orf32 0.46 5.11 0.3 6.05e-7 Atrial fibrillation; CESC cis rs829880 1.000 rs829880 chr12:98845331 G/T cg25150519 chr12:98850993 NA 0.8 11.58 0.58 2.29e-25 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg10360139 chr7:1886902 MAD1L1 -0.4 -5.05 -0.3 8.09e-7 Bipolar disorder and schizophrenia; CESC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -6.77 -0.38 8.2e-11 Bipolar disorder and schizophrenia; CESC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg13114125 chr14:105738426 BRF1 -0.69 -9.02 -0.48 3.84e-17 Mean platelet volume;Platelet distribution width; CESC cis rs4654899 0.931 rs3125161 chr1:21126346 A/G cg05370193 chr1:21551575 ECE1 -0.38 -5.64 -0.33 4.32e-8 Superior frontal gyrus grey matter volume; CESC cis rs6912958 0.712 rs9444526 chr6:88326402 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.31 -5.08 -0.3 7.04e-7 Monocyte percentage of white cells; CESC cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg03467027 chr4:99064603 C4orf37 0.45 5.67 0.33 3.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2354432 0.556 rs2353977 chr1:146839637 G/T cg25205988 chr1:146714368 CHD1L 1.01 8.86 0.48 1.18e-16 Mitochondrial DNA levels; CESC cis rs62344088 0.590 rs62346174 chr5:296308 C/A cg22496380 chr5:211416 CCDC127 -0.89 -5.35 -0.31 1.9e-7 Asthma (childhood onset); CESC cis rs8180040 0.800 rs11920354 chr3:47262246 C/A cg27129171 chr3:47204927 SETD2 -0.67 -9.65 -0.51 4.46e-19 Colorectal cancer; CESC cis rs6964587 0.900 rs6465352 chr7:91775117 A/G cg17063962 chr7:91808500 NA 0.59 8.22 0.45 8.94e-15 Breast cancer; CESC trans rs1941687 0.524 rs6507062 chr18:31374197 G/C cg27147174 chr7:100797783 AP1S1 -0.49 -6.75 -0.38 9.04e-11 Subjective well-being (multi-trait analysis);Subjective well-being; CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg08968635 chr6:28129556 ZNF389 0.42 5.73 0.33 2.7e-8 Depression; CESC cis rs3741151 1.000 rs76570090 chr11:73066321 A/T cg17517138 chr11:73019481 ARHGEF17 1.05 7.11 0.4 1.09e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.69 -9.18 -0.49 1.23e-17 Mean platelet volume; CESC cis rs113835537 0.935 rs117131621 chr11:66422334 C/T cg24851651 chr11:66362959 CCS 0.63 5.68 0.33 3.48e-8 Airway imaging phenotypes; CESC cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.23e-9 Extrinsic epigenetic age acceleration; CESC cis rs2425143 1.000 rs4504072 chr20:34448773 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.78 -7.05 -0.4 1.57e-11 Blood protein levels; CESC cis rs6500602 0.727 rs4786516 chr16:4578641 C/T cg08645402 chr16:4508243 NA 0.51 8.37 0.46 3.41e-15 Schizophrenia; CESC cis rs7100689 0.784 rs1972370 chr10:82127180 A/G cg00277334 chr10:82204260 NA -0.59 -7.35 -0.41 2.39e-12 Post bronchodilator FEV1; CESC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg23708337 chr7:1209742 NA 0.53 5.18 0.3 4.34e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs202629 1 rs202629 chr22:41849975 C/T cg06481639 chr22:41940642 POLR3H 0.53 5.8 0.34 1.86e-8 Cannabis dependence symptom count; CESC cis rs4891159 0.790 rs17059379 chr18:74160316 A/T cg24786174 chr18:74118243 ZNF516 0.7 10.4 0.54 1.82e-21 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05790002 chr16:82033681 SDR42E1 -0.57 -6.45 -0.37 5.34e-10 Gut microbiome composition (summer); CESC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg04772025 chr11:68637568 NA 0.55 6.39 0.37 7.48e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs9379850 0.527 rs9393704 chr6:26358775 T/C cg06606381 chr12:133084897 FBRSL1 -0.76 -6.87 -0.39 4.66e-11 Intelligence (multi-trait analysis); CESC cis rs3204270 0.530 rs57707013 chr17:79635281 C/T cg26965718 chr17:79658957 HGS -0.64 -5.12 -0.3 5.99e-7 Dental caries; CESC cis rs317689 0.513 rs317678 chr12:69692166 C/G cg22834771 chr12:69754056 YEATS4 -0.42 -5.18 -0.3 4.42e-7 Response to diuretic therapy; CESC cis rs2120019 0.608 rs4886414 chr15:75308650 C/T cg17294928 chr15:75287854 SCAMP5 0.9 14.01 0.65 9.17e-34 Blood trace element (Zn levels); CESC cis rs6714710 0.603 rs10432626 chr2:98561153 C/A cg26665480 chr2:98280029 ACTR1B 0.56 7.9 0.44 7.59e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg11211951 chr8:145729740 GPT -0.32 -5.5 -0.32 9.06e-8 Age at first birth; CESC cis rs11098499 0.754 rs28643450 chr4:120245242 G/A cg09307838 chr4:120376055 NA 0.78 10.55 0.54 5.92e-22 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03576787 chr11:32112632 RCN1 0.53 6.21 0.36 2.01e-9 Gut microbiome composition (summer); CESC cis rs7165102 1.000 rs6494528 chr15:65865632 T/G cg11441148 chr15:65824328 PTPLAD1 0.31 5.27 0.31 2.8e-7 Mean corpuscular hemoglobin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17676327 chr2:121010539 RALB 0.55 6.33 0.36 1.04e-9 Gut microbiome composition (summer); CESC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.46 6.11 0.35 3.49e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6963495 0.872 rs73190193 chr7:105164852 A/G cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs533581 0.866 rs475796 chr16:88970776 C/G cg16701003 chr16:89028210 CBFA2T3 0.49 7.18 0.4 7.14e-12 Social autistic-like traits; CESC cis rs796364 0.806 rs34381014 chr2:200916403 C/T cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC cis rs9457247 0.846 rs2757052 chr6:167380174 T/C cg25258033 chr6:167368657 RNASET2 -0.42 -6.25 -0.36 1.63e-9 Crohn's disease; CESC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg19163074 chr7:65112434 INTS4L2 -0.43 -5.34 -0.31 2e-7 Aortic root size; CESC cis rs3733585 0.725 rs10939636 chr4:9972640 T/G cg00071950 chr4:10020882 SLC2A9 -0.71 -11.36 -0.57 1.22e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6456156 0.586 rs6456149 chr6:167463902 T/C cg23791538 chr6:167370224 RNASET2 -0.49 -6.29 -0.36 1.3e-9 Primary biliary cholangitis; CESC cis rs6951245 0.882 rs11764817 chr7:1064610 T/C cg18402987 chr7:1209562 NA 0.61 6.42 0.37 6.29e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9303280 0.901 rs869402 chr17:38068043 C/T cg20243544 chr17:37824526 PNMT 0.47 6.53 0.37 3.41e-10 Self-reported allergy; CESC cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg13722127 chr7:150037890 RARRES2 0.34 5.17 0.3 4.56e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs3008870 0.755 rs2815349 chr1:67472280 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.62 8.04 0.44 3.01e-14 Lymphocyte percentage of white cells; CESC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg02951883 chr7:2050386 MAD1L1 -0.46 -6.04 -0.35 5.28e-9 Bipolar disorder and schizophrenia; CESC cis rs11098499 0.954 rs2389803 chr4:120393511 A/G cg24375607 chr4:120327624 NA -0.45 -5.65 -0.33 4.15e-8 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08672023 chr6:35423591 FANCE -0.63 -7.32 -0.41 2.89e-12 Gut microbiome composition (summer); CESC trans rs11722228 0.522 rs7662229 chr4:10133014 A/T cg26043149 chr18:55253948 FECH 1.0 12.65 0.61 5.33e-29 Gout;Urate levels;Serum uric acid levels; CESC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg13206674 chr6:150067644 NUP43 0.45 6.43 0.37 5.79e-10 Lung cancer; CESC cis rs4919694 1.000 rs112240253 chr10:104753726 C/T cg04362960 chr10:104952993 NT5C2 0.72 5.64 0.33 4.42e-8 Arsenic metabolism; CESC cis rs17376456 0.877 rs12153506 chr5:93360953 T/G cg21475434 chr5:93447410 FAM172A 0.77 6.93 0.39 3.17e-11 Diabetic retinopathy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07317108 chr10:11575102 USP6NL -0.36 -6.07 -0.35 4.44e-9 Gambling; CESC cis rs7666738 0.830 rs28761309 chr4:98867393 C/T cg05340658 chr4:99064831 C4orf37 0.74 10.7 0.55 1.97e-22 Colonoscopy-negative controls vs population controls; CESC trans rs28549925 0.590 rs6949186 chr7:16992446 A/T cg12639933 chr12:57626296 SHMT2 -0.95 -6.1 -0.35 3.74e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs11252926 0.583 rs2066317 chr10:520309 C/T cg03684893 chr10:554711 DIP2C -0.43 -6.64 -0.38 1.78e-10 Psychosis in Alzheimer's disease; CESC cis rs568617 0.953 rs658524 chr11:65647260 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.69 -7.4 -0.41 1.81e-12 Crohn's disease; CESC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg18252515 chr7:66147081 NA -0.47 -6.09 -0.35 4.02e-9 Aortic root size; CESC cis rs11227306 0.934 rs2303385 chr11:65640562 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.49 -5.43 -0.32 1.29e-7 DNA methylation (variation); CESC cis rs10870270 1.000 rs7199 chr10:133769848 C/G cg08754478 chr10:133766260 PPP2R2D -0.59 -7.57 -0.42 6.29e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg09699651 chr6:150184138 LRP11 0.4 5.1 0.3 6.34e-7 Lung cancer; CESC cis rs936229 0.954 rs936230 chr15:75145098 C/T cg14664628 chr15:75095509 CSK 0.79 10.81 0.55 8.13e-23 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs863345 0.604 rs2873593 chr1:158504711 T/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs9916302 0.904 rs10852933 chr17:37698194 G/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.89e-10 Glomerular filtration rate (creatinine); CESC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg04317338 chr11:64019027 PLCB3 0.88 9.16 0.49 1.45e-17 Mean platelet volume; CESC cis rs7582720 1.000 rs114899426 chr2:203771652 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg03060546 chr3:49711283 APEH 0.51 6.91 0.39 3.56e-11 Menarche (age at onset); CESC cis rs4737010 0.501 rs12548116 chr8:41645074 A/G cg08923054 chr8:41654455 ANK1 0.6 7.47 0.42 1.18e-12 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs2235642 0.717 rs2236269 chr16:1652614 T/A cg03771183 chr16:1608904 IFT140 0.38 5.48 0.32 9.93e-8 Coronary artery disease; CESC cis rs11098499 0.863 rs10018280 chr4:120478139 T/G cg24375607 chr4:120327624 NA 0.44 5.34 0.31 1.99e-7 Corneal astigmatism; CESC cis rs7116495 0.786 rs1573501 chr11:71735693 C/T cg10381502 chr11:71823885 C11orf51 -1.16 -6.94 -0.39 3.1e-11 Severe influenza A (H1N1) infection; CESC cis rs7267979 1.000 rs6115159 chr20:25350944 T/C cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.88e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg01516881 chr6:292596 DUSP22 -0.52 -6.66 -0.38 1.59e-10 Menopause (age at onset); CESC cis rs2115630 0.641 rs11073613 chr15:85185893 G/A cg11189052 chr15:85197271 WDR73 -0.38 -5.09 -0.3 6.66e-7 P wave terminal force; CESC cis rs11122272 0.735 rs2739518 chr1:231537633 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.44 -0.42 1.38e-12 Hemoglobin concentration; CESC cis rs7208859 0.524 rs11653098 chr17:29122501 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs17253792 0.822 rs78988988 chr14:56152404 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg03806693 chr22:41940476 POLR3H 1.2 15.07 0.68 1.8e-37 Vitiligo; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09089653 chr5:134734307 H2AFY -0.47 -6.25 -0.36 1.64e-9 Asthma; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg21400344 chr1:25870172 LDLRAP1 -0.49 -7.36 -0.41 2.3e-12 Breast cancer; CESC cis rs9300255 0.739 rs4759415 chr12:123743674 C/T cg05973401 chr12:123451056 ABCB9 -0.5 -5.74 -0.33 2.57e-8 Neutrophil percentage of white cells; CESC cis rs6424115 1.000 rs1018396 chr1:24133612 G/A cg10978503 chr1:24200527 CNR2 0.28 5.61 0.33 5.09e-8 Immature fraction of reticulocytes; CESC cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg22823121 chr1:150693482 HORMAD1 -0.41 -6.29 -0.36 1.29e-9 Tonsillectomy; CESC cis rs7666738 0.515 rs11733968 chr4:98906448 A/C cg05340658 chr4:99064831 C4orf37 -0.58 -7.88 -0.44 8.28e-14 Colonoscopy-negative controls vs population controls; CESC cis rs7085104 0.700 rs6163 chr10:104596924 C/A cg04362960 chr10:104952993 NT5C2 0.51 6.59 0.38 2.39e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg24549020 chr5:56110836 MAP3K1 0.64 7.31 0.41 3.24e-12 Initial pursuit acceleration; CESC cis rs6714710 0.535 rs13033383 chr2:98339513 C/T cg26665480 chr2:98280029 ACTR1B 0.58 7.59 0.42 5.55e-13 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs2742417 0.603 rs1468542 chr3:45779136 A/T cg04837898 chr3:45731254 SACM1L 0.46 6.1 0.35 3.66e-9 Response to anti-depressant treatment in major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18371567 chr11:85376025 CREBZF 0.58 6.1 0.35 3.68e-9 Gut microbiome composition (summer); CESC cis rs72627123 0.867 rs61522544 chr14:74481953 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.65 0.33 4.21e-8 Morning vs. evening chronotype; CESC cis rs7267979 0.789 rs6050472 chr20:25219852 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.6 9.42 0.5 2.37e-18 Liver enzyme levels (alkaline phosphatase); CESC cis rs1003719 0.788 rs2835602 chr21:38469069 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.51 0.46 1.31e-15 Eye color traits; CESC cis rs3096299 0.838 rs3102384 chr16:89411661 T/G cg02187348 chr16:89574699 SPG7 0.51 6.3 0.36 1.22e-9 Multiple myeloma (IgH translocation); CESC cis rs754466 0.958 rs11002341 chr10:79701363 A/C cg17075019 chr10:79541650 NA -0.68 -8.29 -0.45 5.91e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7508 0.640 rs6988638 chr8:17911732 C/G cg18067069 chr8:17937731 ASAH1 -0.39 -5.32 -0.31 2.26e-7 Atrial fibrillation; CESC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg05861140 chr6:150128134 PCMT1 -0.35 -5.07 -0.3 7.45e-7 Lung cancer; CESC cis rs644799 0.672 rs11021347 chr11:95653494 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.66 8.97 0.48 5.49e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11792861 0.926 rs75472294 chr9:111804239 G/A cg14384093 chr9:111878565 C9orf5 -0.41 -5.14 -0.3 5.42e-7 Menarche (age at onset); CESC cis rs8112211 0.954 rs7252835 chr19:38832946 G/A cg14299480 chr19:38876666 GGN -0.45 -6.11 -0.35 3.52e-9 Blood protein levels; CESC trans rs11098499 0.874 rs10022508 chr4:120115228 A/G cg25214090 chr10:38739885 LOC399744 0.61 8.04 0.44 2.91e-14 Corneal astigmatism; CESC cis rs9875589 1.000 rs9875589 chr3:13961157 A/C cg19554555 chr3:13937349 NA 0.43 5.6 0.33 5.36e-8 Ovarian reserve; CESC trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21659725 chr3:3221576 CRBN -0.83 -13.61 -0.64 2.43e-32 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs67311347 0.911 rs6773917 chr3:40469254 G/T cg24209194 chr3:40518798 ZNF619 0.47 6.18 0.36 2.37e-9 Renal cell carcinoma; CESC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg05535760 chr7:792225 HEATR2 -0.74 -7.81 -0.43 1.35e-13 Cerebrospinal P-tau181p levels; CESC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg10792982 chr14:105748885 BRF1 0.41 5.26 0.31 2.95e-7 Mean platelet volume;Platelet distribution width; CESC cis rs62103177 0.608 rs4442895 chr18:77826399 C/G cg12964065 chr18:77638022 KCNG2 -0.46 -5.52 -0.32 8.23e-8 Opioid sensitivity; CESC cis rs3008870 1.000 rs2815351 chr1:67477980 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.98 13.64 0.64 1.82e-32 Lymphocyte percentage of white cells; CESC cis rs35146811 1.000 rs35146811 chr7:99720994 A/C cg22906224 chr7:99728672 NA 0.46 5.46 0.32 1.07e-7 Coronary artery disease; CESC cis rs17253792 0.822 rs74940664 chr14:56135065 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg03709012 chr19:19516395 GATAD2A -0.97 -14.63 -0.67 6.08e-36 Tonsillectomy; CESC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg23978390 chr7:1156363 C7orf50 0.5 5.17 0.3 4.69e-7 Bronchopulmonary dysplasia; CESC cis rs10208940 0.920 rs35005506 chr2:68814238 A/T cg12452813 chr2:68675892 NA 0.53 5.29 0.31 2.54e-7 Urate levels in lean individuals; CESC cis rs17401966 0.964 rs2027331 chr1:10276718 C/T cg15208524 chr1:10270712 KIF1B 0.53 6.91 0.39 3.5e-11 Hepatocellular carcinoma; CESC cis rs11864453 0.612 rs12708925 chr16:72122706 A/T cg01557791 chr16:72042693 DHODH -0.44 -5.68 -0.33 3.54e-8 Fibrinogen levels; CESC cis rs919433 0.889 rs12693816 chr2:198208420 T/A cg03934865 chr2:198174659 NA -0.47 -6.75 -0.38 9.27e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs11088226 1.000 rs2833888 chr21:33927560 A/G cg09050820 chr6:167586206 TCP10L2 0.6 6.07 0.35 4.38e-9 Gastritis; CESC cis rs1003719 0.680 rs2154537 chr21:38502012 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.54 -0.46 1.04e-15 Eye color traits; CESC cis rs6693567 0.565 rs834237 chr1:150363930 A/G cg09579323 chr1:150459698 TARS2 0.48 6.03 0.35 5.58e-9 Migraine; CESC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg22535103 chr8:58192502 C8orf71 -0.94 -10.38 -0.54 2.05e-21 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg05313129 chr8:58192883 C8orf71 -0.51 -5.24 -0.31 3.27e-7 Developmental language disorder (linguistic errors); CESC cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg04450456 chr4:17643702 FAM184B 0.37 5.17 0.3 4.72e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs870825 0.587 rs7682995 chr4:185640684 G/A cg04058563 chr4:185651563 MLF1IP 0.64 7.1 0.4 1.15e-11 Blood protein levels; CESC cis rs2304069 0.507 rs4705407 chr5:149404983 G/T cg12661370 chr5:149340060 SLC26A2 0.46 6.53 0.37 3.4e-10 HIV-1 control; CESC cis rs10918270 0.934 rs9783069 chr1:161936121 A/C cg19735514 chr1:161762739 ATF6 -0.38 -5.7 -0.33 3.24e-8 Parkinson's disease (age of onset); CESC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg02018176 chr4:1364513 KIAA1530 -0.49 -6.36 -0.36 8.91e-10 Longevity; CESC cis rs208520 1.000 rs12194996 chr6:66973366 G/C cg07460842 chr6:66804631 NA 0.75 8.7 0.47 3.46e-16 Exhaled nitric oxide output; CESC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg05255149 chr17:80675120 FN3KRP -0.47 -5.92 -0.34 9.8e-9 Glycated hemoglobin levels; CESC cis rs138880 0.580 rs28562884 chr22:50312869 T/C cg02269571 chr22:50332266 NA -0.68 -6.71 -0.38 1.17e-10 Schizophrenia; CESC cis rs9399135 0.967 rs6929661 chr6:135328792 G/A cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg07343612 chr16:622815 PIGQ -0.55 -8.07 -0.44 2.44e-14 Height; CESC cis rs6912958 0.559 rs173333 chr6:88047754 T/G cg12350822 chr6:88032061 C6orf162;GJB7 0.44 7.8 0.43 1.47e-13 Monocyte percentage of white cells; CESC cis rs3617 0.625 rs7652667 chr3:52866535 C/A cg11645453 chr3:52864694 ITIH4 -0.26 -5.18 -0.3 4.48e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs7640424 0.750 rs13074183 chr3:107851467 G/A cg09227934 chr3:107805635 CD47 -0.46 -5.86 -0.34 1.35e-8 Body mass index; CESC cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.87 0.34 1.33e-8 Tonsillectomy; CESC cis rs72945132 0.619 rs34053053 chr11:70260598 C/T cg14191688 chr11:70257035 CTTN 0.48 5.97 0.34 7.65e-9 Coronary artery disease; CESC cis rs208520 0.526 rs7775830 chr6:66755249 A/G cg07460842 chr6:66804631 NA 1.02 21.41 0.8 9.82e-60 Exhaled nitric oxide output; CESC cis rs10779751 1.000 rs4845987 chr1:11306279 G/C cg08854313 chr1:11322531 MTOR 0.91 14.45 0.66 2.77e-35 Body mass index; CESC cis rs1499614 0.901 rs3936 chr7:66126489 C/T cg08632164 chr7:65971372 NA -0.49 -5.12 -0.3 5.92e-7 Gout; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07475957 chr5:140590251 PCDHB12 -0.47 -6.17 -0.35 2.55e-9 Gut microbiome composition (summer); CESC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg24060327 chr5:131705240 SLC22A5 -0.42 -5.34 -0.31 1.96e-7 Breast cancer; CESC cis rs9309473 0.519 rs2421574 chr2:73908767 C/G cg20560298 chr2:73613845 ALMS1 0.5 7.16 0.4 7.75e-12 Metabolite levels; CESC cis rs2033711 0.622 rs975947 chr19:58898193 C/T cg26874164 chr19:58962979 ZNF324B 0.42 5.52 0.32 8.06e-8 Uric acid clearance; CESC cis rs1163251 0.837 rs660073 chr1:120245173 T/C cg19096424 chr1:120255104 PHGDH 0.52 6.67 0.38 1.52e-10 Blood metabolite levels; CESC cis rs6964587 1.000 rs7791138 chr7:91686789 A/G cg17063962 chr7:91808500 NA 0.57 7.85 0.43 1.05e-13 Breast cancer; CESC cis rs921968 0.565 rs4674328 chr2:219593203 T/C cg02176678 chr2:219576539 TTLL4 -0.43 -7.46 -0.42 1.23e-12 Mean corpuscular hemoglobin concentration; CESC cis rs2072732 0.861 rs12046233 chr1:2960608 A/G cg15211996 chr1:2936768 ACTRT2 0.34 5.44 0.32 1.19e-7 Plateletcrit; CESC cis rs16917546 1.000 rs10995260 chr10:64410580 G/A cg03961010 chr10:64397487 ZNF365 -0.37 -6.11 -0.35 3.55e-9 Basal cell carcinoma; CESC cis rs7224685 0.569 rs2123841 chr17:4022557 G/A cg07607921 chr17:4047574 ZZEF1;CYB5D2 0.49 5.09 0.3 6.96e-7 Type 2 diabetes; CESC cis rs4481887 0.741 rs28616194 chr1:248531904 T/A cg26353448 chr1:248524236 OR2T4 -0.38 -5.35 -0.31 1.9e-7 Common traits (Other); CESC cis rs79387448 0.564 rs77375846 chr2:103155075 T/C cg09003973 chr2:102972529 NA 0.96 7.26 0.41 4.43e-12 Gut microbiota (bacterial taxa); CESC cis rs7208859 0.673 rs216418 chr17:28936537 G/A cg19761014 chr17:28927070 LRRC37B2 0.79 7.48 0.42 1.12e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs826838 1.000 rs11168505 chr12:38939057 A/T cg26384229 chr12:38710491 ALG10B -0.79 -14.01 -0.65 9.85e-34 Heart rate; CESC cis rs7666738 0.830 rs17026973 chr4:98680041 T/A cg05340658 chr4:99064831 C4orf37 0.76 10.99 0.56 2.11e-23 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.735 rs396000 chr6:109519611 A/G cg01475377 chr6:109611718 NA 0.38 5.71 0.33 2.96e-8 Reticulocyte fraction of red cells; CESC cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg11764359 chr7:65958608 NA 0.79 9.42 0.5 2.29e-18 Aortic root size; CESC cis rs1348850 0.651 rs4893936 chr2:178240676 C/G cg22681709 chr2:178499509 PDE11A -0.37 -5.63 -0.33 4.51e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15380607 chr6:138188545 TNFAIP3 0.59 6.86 0.39 4.88e-11 Gut microbiome composition (summer); CESC cis rs847577 0.630 rs11764933 chr7:97825188 G/A cg24562669 chr7:97807699 LMTK2 0.84 13.88 0.65 2.69e-33 Breast cancer; CESC cis rs6964587 0.967 rs9656003 chr7:91766322 A/C cg17063962 chr7:91808500 NA 0.56 7.84 0.43 1.09e-13 Breast cancer; CESC cis rs4253772 0.591 rs6519993 chr22:46656479 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.17 0.45 1.28e-14 LDL cholesterol;Cholesterol, total; CESC trans rs3857536 0.611 rs6927407 chr6:66870010 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.58 -7.58 -0.42 5.87e-13 Blood trace element (Cu levels); CESC cis rs7208859 0.673 rs423151 chr17:28952286 A/G cg04154034 chr17:28927549 LRRC37B2 0.68 6.14 0.35 3.08e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7246657 1.000 rs6508710 chr19:37749886 A/G cg23950597 chr19:37808831 NA -0.57 -6.23 -0.36 1.79e-9 Coronary artery calcification; CESC cis rs763014 0.865 rs8675 chr16:633843 A/G cg00908189 chr16:619842 PIGQ 0.66 9.11 0.49 2.12e-17 Height; CESC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.515 rs11733968 chr4:98906448 A/C cg03676636 chr4:99064102 C4orf37 -0.34 -5.22 -0.31 3.65e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2273669 0.588 rs12205061 chr6:109338161 T/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.33 -0.36 1.03e-9 Prostate cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09645772 chr5:180688272 TRIM52 -0.46 -6.18 -0.35 2.47e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7565301 0.589 rs1123573 chr2:60707588 C/T cg05806717 chr16:30102542 TBX6 -0.37 -6.11 -0.35 3.48e-9 Intelligence (multi-trait analysis);F-cell distribution; CESC cis rs6032067 0.852 rs2233882 chr20:43835683 T/A cg10761708 chr20:43804764 PI3 0.5 5.94 0.34 8.83e-9 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13426340 chr1:167131977 NA -0.61 -6.69 -0.38 1.3e-10 Gut microbiome composition (summer); CESC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg10664184 chr19:17420304 DDA1 0.44 5.18 0.3 4.35e-7 Systemic lupus erythematosus; CESC cis rs11122272 0.735 rs2486729 chr1:231535584 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.74 -0.43 2.14e-13 Hemoglobin concentration; CESC cis rs9900062 0.546 rs2676289 chr17:62705738 A/G cg02598441 chr17:62777298 LOC146880 0.48 5.15 0.3 5.21e-7 QT interval; CESC cis rs9549367 0.577 rs776904 chr13:113810542 C/T cg00898013 chr13:113819073 PROZ -0.51 -6.38 -0.36 7.82e-10 Platelet distribution width; CESC cis rs12893668 0.703 rs2274267 chr14:104029449 G/A cg24130564 chr14:104152367 KLC1 -0.46 -5.43 -0.32 1.27e-7 Reticulocyte count; CESC cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg23711669 chr6:146136114 FBXO30 0.99 15.04 0.68 2.25e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs6496667 0.557 rs2526002 chr15:90965655 C/T cg10434728 chr15:90938212 IQGAP1 0.31 5.45 0.32 1.15e-7 Rheumatoid arthritis; CESC cis rs16854884 0.657 rs6783089 chr3:143738034 T/C cg06585982 chr3:143692056 C3orf58 0.5 6.7 0.38 1.26e-10 Economic and political preferences (feminism/equality); CESC cis rs8060686 0.516 rs7194894 chr16:68145062 C/T cg26727032 chr16:67993705 SLC12A4 -0.52 -6.33 -0.36 1.05e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Tonsillectomy; CESC cis rs60843830 1.000 rs2126129 chr2:212548 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.85 11.23 0.57 3.53e-24 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9393692 0.620 rs9379844 chr6:26291527 A/G cg00631329 chr6:26305371 NA 0.35 5.7 0.33 3.24e-8 Educational attainment; CESC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg12963246 chr6:28129442 ZNF389 0.41 5.97 0.34 7.49e-9 Parkinson's disease; CESC trans rs10242455 0.702 rs73401510 chr7:99065812 A/C cg09045935 chr12:6379348 NA 0.85 7.12 0.4 1.03e-11 Blood metabolite levels; CESC cis rs694739 0.726 rs17857342 chr11:64138905 T/G cg23796481 chr11:64053134 BAD;GPR137 0.58 7.05 0.4 1.58e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs17384381 1.000 rs79695640 chr1:85836073 T/C cg16011679 chr1:85725395 C1orf52 0.82 8.18 0.45 1.21e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs67311347 1.000 rs2168111 chr3:40395325 T/G cg24209194 chr3:40518798 ZNF619 0.45 5.96 0.34 7.9e-9 Renal cell carcinoma; CESC cis rs8077577 0.895 rs1563373 chr17:18114228 G/A cg16794390 chr17:18148240 FLII 0.41 5.63 0.33 4.55e-8 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.20.50358104F chr20:50924697 NA -0.52 -6.11 -0.35 3.57e-9 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs2413546 chr22:39107001 G/A cg21395723 chr22:39101663 GTPBP1 0.43 5.45 0.32 1.13e-7 Menopause (age at onset); CESC cis rs782590 0.837 rs2627769 chr2:55927288 G/C cg18811423 chr2:55921094 PNPT1 0.83 13.82 0.65 4.6e-33 Metabolic syndrome; CESC cis rs3106136 0.967 rs2632399 chr4:95153741 G/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.01 -0.4 1.94e-11 Capecitabine sensitivity; CESC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg27266027 chr21:40555129 PSMG1 0.46 5.41 0.32 1.38e-7 Cognitive function; CESC cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg05340658 chr4:99064831 C4orf37 0.69 9.38 0.5 3.07e-18 Colonoscopy-negative controls vs population controls; CESC cis rs9929218 0.954 rs2059254 chr16:68817439 C/T cg05785947 chr16:68771059 CDH1 0.38 5.2 0.3 4.04e-7 Colorectal cancer; CESC cis rs2243480 1.000 rs313831 chr7:65551226 C/T cg13147721 chr7:65941812 NA -1.02 -9.7 -0.51 3.08e-19 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10261751 chr16:1505328 CLCN7 -0.64 -7.36 -0.41 2.31e-12 Gut microbiome composition (summer); CESC cis rs4481887 1.000 rs6697735 chr1:248465315 G/C cg00666640 chr1:248458726 OR2T12 0.37 6.04 0.35 5.32e-9 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04016606 chr6:167041530 RPS6KA2 0.53 6.02 0.35 5.69e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05636869 chr5:52777880 FST -0.48 -6.43 -0.37 5.89e-10 Fibrinogen levels; CESC cis rs4919087 0.561 rs61861844 chr10:99064171 G/A cg25902810 chr10:99078978 FRAT1 -0.51 -5.14 -0.3 5.21e-7 Monocyte count; CESC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Depression; CESC cis rs6598955 0.724 rs12726972 chr1:26639634 A/G cg19743891 chr1:26644573 UBXN11;CD52 0.26 5.1 0.3 6.37e-7 Obesity-related traits; CESC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg06420487 chr17:61919686 SMARCD2 -0.44 -5.21 -0.3 3.83e-7 Prudent dietary pattern; CESC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg00129232 chr17:37814104 STARD3 -0.54 -7.03 -0.4 1.78e-11 Glomerular filtration rate (creatinine); CESC cis rs36051895 0.664 rs884132 chr9:5114522 G/A cg02405213 chr9:5042618 JAK2 -0.51 -6.22 -0.36 1.98e-9 Pediatric autoimmune diseases; CESC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs11718455 0.921 rs11130020 chr3:44009459 C/T cg08738300 chr3:44038990 NA 0.46 6.24 0.36 1.68e-9 Coronary artery disease; CESC cis rs9611565 0.921 rs2235846 chr22:41741042 G/C cg03806693 chr22:41940476 POLR3H -0.71 -8.52 -0.46 1.2e-15 Vitiligo; CESC cis rs7762018 0.655 rs2184195 chr6:170148397 C/T cg13891659 chr6:170190454 C6orf122;C6orf208 0.67 6.53 0.37 3.28e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg15254786 chr2:207630414 MDH1B;FASTKD2 -0.5 -6.77 -0.38 8.3e-11 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs72945132 0.882 rs7128969 chr11:70205017 C/A cg00319359 chr11:70116639 PPFIA1 0.73 6.87 0.39 4.64e-11 Coronary artery disease; CESC cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg18876405 chr7:65276391 NA 0.49 5.35 0.31 1.89e-7 Aortic root size; CESC cis rs7937682 0.889 rs10749984 chr11:111492861 T/C cg22437258 chr11:111473054 SIK2 0.72 9.66 0.51 4.24e-19 Primary sclerosing cholangitis; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14321424 chr11:46403087 MDK 0.47 6.12 0.35 3.34e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7296418 0.961 rs10848428 chr12:123572495 C/T cg00376283 chr12:123451042 ABCB9 0.76 10.96 0.56 2.75e-23 Platelet count; CESC trans rs459571 0.920 rs417142 chr9:136891370 G/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.57 -7.3 -0.41 3.37e-12 Platelet distribution width; CESC cis rs1707322 0.721 rs10430123 chr1:46221440 T/C cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg11279151 chr3:101281821 RG9MTD1 -0.44 -5.6 -0.33 5.48e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2635047 1.000 rs2635049 chr18:44687303 C/T cg24371990 chr18:44770781 NA -0.34 -5.38 -0.31 1.67e-7 Educational attainment; CESC cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.87 9.04 0.49 3.35e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg17724175 chr1:150552817 MCL1 -0.35 -5.6 -0.33 5.37e-8 Tonsillectomy; CESC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg18451016 chr1:38461880 NA -0.4 -5.53 -0.32 7.54e-8 Coronary artery disease; CESC cis rs2204008 0.626 rs11520260 chr12:38330092 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.11 0.35 3.53e-9 Bladder cancer; CESC cis rs8067354 0.609 rs1292066 chr17:57932314 T/A cg02344993 chr17:57696989 CLTC 0.7 8.66 0.47 4.61e-16 Hemoglobin concentration; CESC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg00149659 chr3:10157352 C3orf10 0.6 6.3 0.36 1.27e-9 Alzheimer's disease; CESC cis rs1538970 0.816 rs12029322 chr1:45970446 C/T cg03146154 chr1:46216737 IPP 0.49 5.57 0.32 6.31e-8 Platelet count; CESC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.06 -0.35 4.65e-9 Parkinson's disease; CESC cis rs7666738 0.830 rs13144564 chr4:98939276 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs3806701 0.619 rs6442008 chr3:46645753 C/T cg21489266 chr3:46619131 LRRC2;TDGF1 -0.41 -6.24 -0.36 1.73e-9 Blood protein levels; CESC cis rs367615 1.000 rs367615 chr5:108948937 C/T cg17395555 chr5:108820864 NA -0.46 -6.81 -0.39 6.5e-11 Colorectal cancer (SNP x SNP interaction); CESC cis rs10838687 0.736 rs4647741 chr11:47254010 T/C cg25783544 chr11:47291846 MADD 0.58 6.63 0.38 1.9e-10 Proinsulin levels; CESC cis rs9815354 0.680 rs73073263 chr3:42018666 C/A cg03022575 chr3:42003672 ULK4 0.74 6.64 0.38 1.79e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs1256061 0.533 rs2357479 chr14:64792764 G/T cg21174375 chr14:64681225 SYNE2 0.53 7.02 0.4 1.91e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9443645 0.527 rs12196485 chr6:79556871 A/G cg05283184 chr6:79620031 NA -0.37 -5.32 -0.31 2.26e-7 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15356780 chr14:90422831 TDP1 -0.45 -6.56 -0.37 2.74e-10 Gambling; CESC cis rs2404602 0.692 rs4442773 chr15:77031633 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.45e-28 Prudent dietary pattern; CESC trans rs1814175 0.645 rs4625470 chr11:49983769 T/C cg15704280 chr7:45808275 SEPT13 -1.01 -19.02 -0.76 1.83e-51 Height; CESC cis rs698813 0.674 rs11678787 chr2:44496315 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.41 0.32 1.39e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg19077165 chr18:44547161 KATNAL2 -0.53 -7.82 -0.43 1.22e-13 Personality dimensions; CESC cis rs34779708 0.931 rs11592404 chr10:35273476 G/A cg04310649 chr10:35416472 CREM -0.5 -5.97 -0.34 7.61e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg12310025 chr6:25882481 NA 0.45 6.48 0.37 4.54e-10 Intelligence (multi-trait analysis); CESC cis rs4642101 0.640 rs12629398 chr3:12826799 A/G cg05775895 chr3:12838266 CAND2 0.4 6.15 0.35 2.91e-9 QRS complex (12-leadsum); CESC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.44e-10 Depression; CESC cis rs5758659 0.657 rs5758587 chr22:42517636 C/G cg00645731 chr22:42541494 CYP2D7P1 0.32 5.55 0.32 6.8e-8 Cognitive function; CESC cis rs7662987 0.517 rs2602865 chr4:100034841 T/C cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC cis rs9768139 0.733 rs12698209 chr7:158117595 A/G cg25566285 chr7:158114605 PTPRN2 -0.45 -7.63 -0.42 4.2e-13 Calcium levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02667081 chr16:71880439 ATXN1L -0.44 -6.34 -0.36 1.01e-9 Gambling; CESC cis rs11077998 0.967 rs4614761 chr17:80505809 C/T cg20173014 chr17:80541737 FOXK2 -0.33 -5.23 -0.31 3.42e-7 Reticulocyte fraction of red cells; CESC cis rs3015497 0.646 rs871643 chr14:51107452 T/C cg26011998 chr14:51135199 SAV1 -0.6 -6.72 -0.38 1.13e-10 Mean platelet volume; CESC cis rs910316 0.737 rs398896 chr14:75482827 C/A cg11812906 chr14:75593930 NEK9 -0.81 -13.04 -0.63 2.4e-30 Height; CESC cis rs9549367 0.713 rs9549691 chr13:113861606 A/C cg00898013 chr13:113819073 PROZ -0.57 -8.05 -0.44 2.75e-14 Platelet distribution width; CESC cis rs796364 0.616 rs2030653 chr2:200677625 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.55 5.14 0.3 5.3e-7 Schizophrenia; CESC cis rs4835473 0.766 rs6537222 chr4:144892612 T/C cg25736465 chr4:144833511 NA 0.39 5.95 0.34 8.36e-9 Immature fraction of reticulocytes; CESC cis rs9300255 0.739 rs10846491 chr12:123753492 C/G cg00376283 chr12:123451042 ABCB9 0.73 9.19 0.49 1.2e-17 Neutrophil percentage of white cells; CESC cis rs9902453 0.817 rs2729449 chr17:28089751 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.61 -0.47 6.65e-16 Coffee consumption (cups per day); CESC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg04944784 chr2:26401820 FAM59B -0.67 -7.75 -0.43 2e-13 Gut microbiome composition (summer); CESC cis rs2404602 0.532 rs744336 chr15:76674624 T/C cg23625390 chr15:77176239 SCAPER 0.35 5.05 0.3 8.32e-7 Blood metabolite levels; CESC cis rs79349575 0.783 rs62075839 chr17:46996434 G/C cg16584676 chr17:46985605 UBE2Z 0.53 6.6 0.38 2.25e-10 Type 2 diabetes; CESC cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg18337363 chr3:52569053 NT5DC2 0.31 5.56 0.32 6.63e-8 Bipolar disorder; CESC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg18230493 chr5:56204884 C5orf35 -0.74 -8.69 -0.47 3.77e-16 Initial pursuit acceleration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02505454 chr12:38493678 NA 0.41 6.02 0.35 5.66e-9 Fibrinogen levels; CESC cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg08109568 chr15:31115862 NA -0.7 -9.3 -0.5 5.56e-18 Huntington's disease progression; CESC cis rs7122539 0.646 rs569818 chr11:66570749 G/A cg24851651 chr11:66362959 CCS 0.49 7.05 0.4 1.51e-11 HIV-1 susceptibility; CESC trans rs11039798 0.582 rs1304193 chr11:48688588 C/T cg15704280 chr7:45808275 SEPT13 0.65 6.5 0.37 4.05e-10 Axial length; CESC cis rs12137294 0.866 rs1077883 chr1:205210415 G/T cg21643547 chr1:205240462 TMCC2 -0.34 -5.48 -0.32 9.82e-8 Red cell distribution width; CESC trans rs561341 0.769 rs9899093 chr17:30191954 C/G cg20587970 chr11:113659929 NA -1.0 -11.16 -0.57 5.94e-24 Hip circumference adjusted for BMI; CESC cis rs13242816 1.000 rs66985071 chr7:116130433 C/T cg04696780 chr7:116139425 CAV2 -0.61 -5.56 -0.32 6.58e-8 P wave duration; CESC cis rs6812193 0.518 rs2869881 chr4:77205745 T/C cg20311846 chr4:77356250 SHROOM3 -0.31 -5.55 -0.32 7.07e-8 Parkinson's disease; CESC cis rs6088580 0.634 rs9789792 chr20:32957709 G/A cg08999081 chr20:33150536 PIGU -0.65 -11.33 -0.57 1.54e-24 Glomerular filtration rate (creatinine); CESC cis rs6866344 0.697 rs72812613 chr5:178135257 G/A cg10224037 chr5:178157518 ZNF354A 0.69 7.69 0.43 2.83e-13 Neutrophil percentage of white cells; CESC cis rs9486715 0.838 rs7452350 chr6:96883326 C/A cg18709589 chr6:96969512 KIAA0776 0.45 6.46 0.37 5.05e-10 Headache; CESC cis rs4523957 0.548 rs7225623 chr17:2089548 T/C cg16513277 chr17:2031491 SMG6 -0.63 -8.81 -0.48 1.7e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7512552 0.698 rs12028001 chr1:150407820 C/T cg15654264 chr1:150340011 RPRD2 0.4 5.29 0.31 2.55e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs718433 0.584 rs2075478 chr14:22218051 C/T cg02257791 chr14:22217085 NA -0.32 -5.08 -0.3 7.19e-7 Intraocular pressure; CESC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg27266027 chr21:40555129 PSMG1 0.44 5.23 0.31 3.4e-7 Cognitive function; CESC cis rs7103648 0.966 rs11500477 chr11:47409051 T/A cg20307385 chr11:47447363 PSMC3 0.96 15.56 0.69 3.3e-39 Diastolic blood pressure;Systolic blood pressure; CESC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg18350739 chr11:68623251 NA -0.44 -6.42 -0.37 6.13e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs933688 0.938 rs7705465 chr5:90680949 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 14.27 0.66 1.16e-34 Smoking behavior; CESC cis rs2576037 0.901 rs2576036 chr18:44587102 G/T cg19077165 chr18:44547161 KATNAL2 -0.57 -8.04 -0.44 2.98e-14 Personality dimensions; CESC cis rs4234798 1.000 rs4234798 chr4:7219933 G/T cg18431297 chr4:7219810 SORCS2 -0.45 -7.27 -0.41 4.06e-12 Insulin-like growth factors; CESC cis rs2243480 1.000 rs906134 chr7:65444288 G/C cg18252515 chr7:66147081 NA -1.24 -12.17 -0.6 2.31e-27 Diabetic kidney disease; CESC trans rs11098499 0.697 rs4373140 chr4:120307698 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC trans rs561341 0.882 rs72825748 chr17:30367396 G/A cg27661571 chr11:113659931 NA -0.85 -7.76 -0.43 1.87e-13 Hip circumference adjusted for BMI; CESC cis rs4132509 0.793 rs6694738 chr1:243715210 C/A cg21452805 chr1:244014465 NA 0.61 6.48 0.37 4.48e-10 RR interval (heart rate); CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg05215272 chr17:6899095 ALOX12 0.44 8.41 0.46 2.61e-15 Tonsillectomy; CESC cis rs12530845 0.943 rs60858457 chr7:135336918 T/C cg23117316 chr7:135346802 PL-5283 -0.45 -5.46 -0.32 1.07e-7 Red blood cell traits; CESC cis rs7927592 0.731 rs7108376 chr11:68347870 A/G cg01657329 chr11:68192670 LRP5 0.48 6.31 0.36 1.14e-9 Total body bone mineral density; CESC trans rs1973993 0.669 rs510552 chr1:96891671 A/G cg10631902 chr5:14652156 NA 0.61 9.43 0.5 2.11e-18 Weight; CESC cis rs9815354 0.597 rs79626430 chr3:42023786 A/G cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs2046867 0.818 rs1502758 chr3:72865126 A/G cg25664220 chr3:72788482 NA -0.45 -6.63 -0.38 1.85e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs287982 0.800 rs13429581 chr2:9963443 T/C cg10881225 chr2:9984929 TAF1B 0.42 5.31 0.31 2.37e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs228437 1.000 rs228448 chr6:134903308 C/T cg24504307 chr6:134963096 NA 0.53 5.71 0.33 2.95e-8 Melanoma; CESC cis rs72945132 0.882 rs12289915 chr11:70131956 G/C cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs7130144 0.541 rs60642492 chr11:130465155 G/A cg26307797 chr11:130446613 NA -0.79 -7.11 -0.4 1.07e-11 Urate levels in lean individuals; CESC cis rs3820068 0.524 rs34094056 chr1:15824154 G/T cg18192808 chr1:15853278 DNAJC16 0.44 5.16 0.3 4.93e-7 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27194164 chr19:17666205 GLT25D1 0.56 6.36 0.36 8.94e-10 Gut microbiome composition (summer); CESC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg08968635 chr6:28129556 ZNF389 0.37 5.04 0.3 8.56e-7 Parkinson's disease; CESC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg21963583 chr11:68658836 MRPL21 0.41 5.5 0.32 9.14e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs3820068 0.608 rs7516683 chr1:16020502 A/G cg18133145 chr1:16060689 PLEKHM2 0.41 5.28 0.31 2.71e-7 Systolic blood pressure; CESC cis rs853679 0.882 rs9380064 chr6:28143118 A/G cg18032046 chr6:28092343 ZSCAN16 -0.75 -6.42 -0.37 6.32e-10 Depression; CESC cis rs2180341 0.814 rs9401959 chr6:127736464 T/C cg24812749 chr6:127587940 RNF146 0.84 12.05 0.59 5.93e-27 Breast cancer; CESC cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.03 -0.4 1.74e-11 Total body bone mineral density; CESC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg07153921 chr17:41440717 NA -0.43 -5.69 -0.33 3.27e-8 Menopause (age at onset); CESC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg18252515 chr7:66147081 NA -0.44 -5.96 -0.34 8.18e-9 Aortic root size; CESC cis rs4700695 0.719 rs27087 chr5:65453050 G/A cg21114390 chr5:65439923 SFRS12 -0.48 -5.9 -0.34 1.14e-8 Facial morphology (factor 19); CESC cis rs6577655 0.517 rs6983560 chr8:135584553 C/T cg17885191 chr8:135476712 NA -0.44 -5.07 -0.3 7.59e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs6424115 0.830 rs1130320 chr1:24200606 A/G cg10978503 chr1:24200527 CNR2 0.33 6.62 0.38 1.93e-10 Immature fraction of reticulocytes; CESC cis rs17253792 0.822 rs77250916 chr14:56042208 A/G cg01858014 chr14:56050164 KTN1 -0.99 -7.46 -0.42 1.21e-12 Putamen volume; CESC cis rs12130219 0.500 rs4845743 chr1:152184149 A/G cg26879891 chr1:152191343 HRNR -0.42 -6.68 -0.38 1.38e-10 Inflammatory skin disease; CESC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg06481639 chr22:41940642 POLR3H 0.64 6.65 0.38 1.64e-10 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16702713 chr5:118407037 DMXL1 0.54 6.74 0.38 9.6e-11 Gut microbiome composition (summer); CESC trans rs634534 0.562 rs1151505 chr11:65734539 C/T cg17712092 chr4:129076599 LARP1B 0.63 8.49 0.46 1.49e-15 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs4654899 0.965 rs6692081 chr1:21296363 T/C cg05370193 chr1:21551575 ECE1 0.39 5.9 0.34 1.12e-8 Superior frontal gyrus grey matter volume; CESC cis rs9611565 0.729 rs12165508 chr22:41819960 T/C cg06634786 chr22:41940651 POLR3H 0.45 5.33 0.31 2.08e-7 Vitiligo; CESC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.38 0.31 1.66e-7 Bipolar disorder; CESC cis rs9916302 0.861 rs8079590 chr17:37426201 T/C cg15445000 chr17:37608096 MED1 0.4 6.45 0.37 5.35e-10 Glomerular filtration rate (creatinine); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg10735211 chr4:4310922 ZNF509 -0.51 -6.38 -0.36 7.92e-10 Psoriatic arthritis; CESC cis rs7246657 0.943 rs1382357 chr19:37977609 G/A cg23950597 chr19:37808831 NA -0.58 -6.39 -0.37 7.52e-10 Coronary artery calcification; CESC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg19723775 chr5:179050963 HNRNPH1 0.4 5.1 0.3 6.4e-7 Lung cancer; CESC cis rs9300255 0.510 rs1790109 chr12:123637752 C/G cg19016782 chr12:123741754 C12orf65 -0.4 -5.68 -0.33 3.46e-8 Neutrophil percentage of white cells; CESC cis rs7084402 0.934 rs1649067 chr10:60305240 T/C cg07615347 chr10:60278583 BICC1 0.59 9.33 0.5 4.35e-18 Refractive error; CESC trans rs7937682 0.889 rs567859 chr11:111486738 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.01 0.35 6.26e-9 Primary sclerosing cholangitis; CESC cis rs4819052 0.788 rs35323494 chr21:46703739 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.8 10.47 0.54 1.08e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10504229 0.679 rs2317991 chr8:58035080 C/T cg22535103 chr8:58192502 C8orf71 0.58 6.65 0.38 1.68e-10 Developmental language disorder (linguistic errors); CESC cis rs9788682 1.000 rs35212593 chr15:78831826 G/A cg24631222 chr15:78858424 CHRNA5 0.81 10.53 0.54 6.79e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs9905704 0.671 rs2068710 chr17:56594535 C/G cg12560992 chr17:57184187 TRIM37 -0.63 -5.99 -0.35 6.89e-9 Testicular germ cell tumor; CESC trans rs61931739 0.534 rs11053010 chr12:34093228 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.25 0.45 7.65e-15 Morning vs. evening chronotype; CESC cis rs11122272 0.735 rs2491410 chr1:231532287 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.05 -0.44 2.72e-14 Hemoglobin concentration; CESC cis rs4722166 0.630 rs12700391 chr7:22777327 C/A cg13104385 chr7:22767384 IL6 0.48 6.43 0.37 5.96e-10 Lung cancer; CESC cis rs2735413 0.709 rs4395084 chr16:78088011 C/G cg04733911 chr16:78082701 NA -0.53 -8.44 -0.46 2.05e-15 Systolic blood pressure (alcohol consumption interaction); CESC cis rs9399401 0.667 rs6922607 chr6:142703483 A/G cg03128060 chr6:142623767 GPR126 0.37 6.56 0.37 2.73e-10 Chronic obstructive pulmonary disease; CESC cis rs4642101 0.765 rs9872103 chr3:12827452 G/T cg05775895 chr3:12838266 CAND2 0.38 5.69 0.33 3.31e-8 QRS complex (12-leadsum); CESC cis rs28374715 0.578 rs7169543 chr15:41620405 T/C cg20272979 chr15:41787780 ITPKA 0.47 5.57 0.32 6.19e-8 Ulcerative colitis; CESC cis rs2404602 0.647 rs12440965 chr15:76958591 G/A cg23625390 chr15:77176239 SCAPER -0.39 -5.04 -0.3 8.6e-7 Blood metabolite levels; CESC cis rs3008870 0.755 rs6657065 chr1:67384639 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.64 8.45 0.46 1.98e-15 Lymphocyte percentage of white cells; CESC cis rs9913156 0.793 rs55677157 chr17:4576620 C/T cg19197139 chr17:4613644 ARRB2 0.93 10.48 0.54 9.99e-22 Lymphocyte counts; CESC cis rs372883 0.648 rs2832297 chr21:30742996 A/C cg24692254 chr21:30365293 RNF160 0.48 6.06 0.35 4.68e-9 Pancreatic cancer; CESC cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg10556349 chr10:835070 NA 0.63 5.98 0.34 7.25e-9 Eosinophil percentage of granulocytes; CESC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg07677032 chr17:61819896 STRADA 0.51 6.75 0.38 9.15e-11 Prudent dietary pattern; CESC trans rs79976124 0.837 rs12194087 chr6:66644399 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 8.16 0.45 1.39e-14 Type 2 diabetes; CESC cis rs6665290 0.904 rs2297416 chr1:227172935 C/G cg10327440 chr1:227177885 CDC42BPA -1.21 -28.92 -0.87 5.81e-84 Myeloid white cell count; CESC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg17724175 chr1:150552817 MCL1 0.32 5.03 0.3 8.98e-7 Melanoma; CESC cis rs6088590 0.965 rs6087639 chr20:33443866 G/A cg24642439 chr20:33292090 TP53INP2 0.85 11.98 0.59 1.06e-26 Coronary artery disease; CESC cis rs3771570 1.000 rs62193204 chr2:242315443 A/G cg21155796 chr2:242212141 HDLBP 0.6 5.27 0.31 2.89e-7 Prostate cancer; CESC cis rs2456568 0.570 rs1518579 chr11:93656821 A/G cg26875233 chr11:93583750 C11orf90 -0.33 -5.87 -0.34 1.28e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs8028182 0.636 rs10152155 chr15:75701554 A/T cg20655648 chr15:75932815 IMP3 0.48 5.99 0.35 6.87e-9 Sudden cardiac arrest; CESC cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg17211192 chr8:82754475 SNX16 -0.61 -7.92 -0.44 6.75e-14 Diastolic blood pressure; CESC cis rs7447927 0.950 rs13181561 chr5:138850905 A/G cg26929925 chr5:138714136 SLC23A1 -0.42 -6.73 -0.38 1.04e-10 Esophageal squamous cell carcinoma; CESC cis rs35110281 0.744 rs8131027 chr21:45104908 G/C cg21573476 chr21:45109991 RRP1B -0.43 -6.15 -0.35 2.84e-9 Mean corpuscular volume; CESC cis rs11072804 1 rs11072804 chr15:79078486 T/G cg04896959 chr15:78267971 NA 0.34 5.11 0.3 6.16e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg14345882 chr6:26364793 BTN3A2 0.41 5.12 0.3 5.79e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg10523679 chr1:76189770 ACADM 0.64 6.1 0.35 3.73e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2404602 0.532 rs206205 chr15:76736091 T/G cg00316803 chr15:76480434 C15orf27 -0.37 -5.73 -0.33 2.74e-8 Blood metabolite levels; CESC cis rs8028182 0.501 rs11072553 chr15:75932777 C/T cg20655648 chr15:75932815 IMP3 0.55 6.69 0.38 1.34e-10 Sudden cardiac arrest; CESC cis rs367943 0.730 rs2914174 chr5:112978531 C/T cg12552261 chr5:112820674 MCC -0.46 -5.43 -0.32 1.27e-7 Type 2 diabetes; CESC cis rs2412819 0.542 rs62018894 chr15:43912987 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.68 0.38 1.38e-10 Lung cancer; CESC cis rs3820928 1.000 rs6752707 chr2:227766822 C/G cg11843606 chr2:227700838 RHBDD1 -0.43 -5.71 -0.33 3.04e-8 Pulmonary function; CESC cis rs2228479 0.850 rs2238532 chr16:89863672 T/C cg14709524 chr16:89940631 TCF25 0.91 6.77 0.38 8.14e-11 Skin colour saturation; CESC cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg08564027 chr20:61660810 NA 0.9 15.36 0.69 1.69e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs561341 0.843 rs2028067 chr17:30239698 T/C cg13647721 chr17:30228624 UTP6 0.76 8.74 0.47 2.66e-16 Hip circumference adjusted for BMI; CESC cis rs3820068 0.603 rs6429768 chr1:15963531 G/A cg13390004 chr1:15929781 NA 0.37 5.9 0.34 1.11e-8 Systolic blood pressure; CESC cis rs2249694 0.919 rs10857769 chr10:135405047 T/C cg19469447 chr10:135341870 CYP2E1 0.36 5.06 0.3 7.96e-7 Obesity-related traits; CESC cis rs7917772 0.502 rs2296584 chr10:104244323 T/A cg22532475 chr10:104410764 TRIM8 -0.33 -5.65 -0.33 4.1e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9910055 0.552 rs4793084 chr17:42317371 G/T cg19774624 chr17:42201019 HDAC5 0.47 6.07 0.35 4.35e-9 Total body bone mineral density; CESC cis rs2294693 0.947 rs4714417 chr6:40987782 A/G cg14769373 chr6:40998127 UNC5CL -0.48 -6.49 -0.37 4.16e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg16240275 chr20:61666158 NCRNA00029 -0.5 -8.58 -0.47 8.36e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg18490616 chr2:88469792 THNSL2 0.55 5.25 0.31 3.06e-7 Plasma clusterin levels; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg18789337 chr6:114180353 MARCKS -0.45 -6.17 -0.35 2.59e-9 Height; CESC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs916888 0.821 rs70602 chr17:44859715 T/C cg17911788 chr17:44343683 NA 0.53 7.06 0.4 1.46e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1957429 0.520 rs72625647 chr14:65344106 T/C cg23373153 chr14:65346875 NA -0.84 -6.32 -0.36 1.13e-9 Pediatric areal bone mineral density (radius); CESC cis rs9768139 0.733 rs71545585 chr7:158118672 G/A cg25566285 chr7:158114605 PTPRN2 0.47 7.45 0.42 1.35e-12 Calcium levels; CESC cis rs11677416 1.000 rs2071375 chr2:113535438 C/T cg27083787 chr2:113543245 IL1A 0.6 7.49 0.42 1.01e-12 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs926938 0.584 rs1286561 chr1:115375428 T/C cg12756093 chr1:115239321 AMPD1 -0.45 -6.13 -0.35 3.19e-9 Autism; CESC cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg11764359 chr7:65958608 NA -0.82 -9.47 -0.5 1.64e-18 Aortic root size; CESC trans rs7902708 0.920 rs7095538 chr10:54425675 G/A cg26219051 chr22:43739629 SCUBE1 -0.5 -6.34 -0.36 9.72e-10 Bone properties (heel); CESC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4803468 1.000 rs10417997 chr19:41902361 G/A cg14132834 chr19:41945861 ATP5SL -0.57 -7.1 -0.4 1.13e-11 Height; CESC cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg00409905 chr10:38381863 ZNF37A -0.45 -6.04 -0.35 5.25e-9 Extrinsic epigenetic age acceleration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00040446 chr1:40367965 MYCL1 -0.43 -6.28 -0.36 1.34e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12038521 chr19:2111714 AP3D1 0.47 6.43 0.37 5.79e-10 Fibrinogen levels; CESC cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg18180107 chr4:99064573 C4orf37 0.39 5.13 0.3 5.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7072216 0.727 rs6584199 chr10:100169983 A/G cg26618903 chr10:100175079 PYROXD2 -0.37 -5.76 -0.33 2.33e-8 Metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18093619 chr15:28367157 HERC2 0.43 6.01 0.35 6.14e-9 Fibrinogen levels; CESC cis rs4642101 0.765 rs1985428 chr3:12829315 A/G cg05775895 chr3:12838266 CAND2 -0.35 -5.08 -0.3 7.19e-7 QRS complex (12-leadsum); CESC cis rs7586879 0.681 rs6705446 chr2:25118608 T/C cg01884057 chr2:25150051 NA 0.37 7.12 0.4 1.03e-11 Body mass index; CESC trans rs1908814 0.516 rs10113042 chr8:11793178 A/G cg15556689 chr8:8085844 FLJ10661 0.52 6.32 0.36 1.12e-9 Neuroticism; CESC cis rs7551222 0.749 rs2887429 chr1:204565012 G/T cg20240347 chr1:204465584 NA -0.26 -5.39 -0.31 1.57e-7 Schizophrenia; CESC cis rs7618501 0.521 rs11709573 chr3:49956628 C/T cg24110177 chr3:50126178 RBM5 -0.52 -7.12 -0.4 1.04e-11 Intelligence (multi-trait analysis); CESC trans rs1945213 0.694 rs34537090 chr11:55843285 G/C cg15704280 chr7:45808275 SEPT13 0.69 6.68 0.38 1.4e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs524281 0.861 rs2889313 chr11:65966066 G/C cg14036092 chr11:66035641 RAB1B -0.6 -6.1 -0.35 3.77e-9 Electroencephalogram traits; CESC cis rs2997447 0.601 rs61776580 chr1:26432719 C/T cg24596570 chr1:26146463 FAM54B;LOC646471 0.65 5.58 0.32 6.05e-8 QRS complex (12-leadsum); CESC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg12311346 chr5:56204834 C5orf35 -0.73 -8.81 -0.48 1.71e-16 Initial pursuit acceleration; CESC cis rs4835473 0.932 rs12509642 chr4:144658233 C/T cg25736465 chr4:144833511 NA -0.33 -5.2 -0.3 4.04e-7 Immature fraction of reticulocytes; CESC cis rs62064224 0.509 rs2302276 chr17:30791503 C/T cg18200150 chr17:30822561 MYO1D 0.43 5.55 0.32 6.81e-8 Schizophrenia; CESC cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg04450456 chr4:17643702 FAM184B 0.4 5.6 0.33 5.39e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6584283 0.716 rs10786558 chr10:101287610 G/A cg09788492 chr10:101292477 NKX2-3 0.32 5.89 0.34 1.15e-8 Ulcerative colitis; CESC cis rs595982 0.559 rs17206700 chr19:49361255 A/G cg15549821 chr19:49342101 PLEKHA4 -0.71 -8.12 -0.45 1.75e-14 Red cell distribution width; CESC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg27170947 chr2:26402098 FAM59B -0.62 -7.53 -0.42 8.16e-13 Gut microbiome composition (summer); CESC cis rs11997175 0.603 rs7462153 chr8:33814607 C/T ch.8.33884649F chr8:33765107 NA 0.49 5.9 0.34 1.09e-8 Body mass index; CESC cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg05234568 chr11:5960015 NA -0.65 -7.71 -0.43 2.51e-13 DNA methylation (variation); CESC cis rs9768139 0.708 rs896782 chr7:158114115 G/A cg06219351 chr7:158114137 PTPRN2 -0.56 -8.97 -0.48 5.67e-17 Calcium levels; CESC cis rs5769765 0.954 rs5769762 chr22:50264042 G/A cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23475963 chr7:128379258 CALU -0.42 -6.04 -0.35 5.15e-9 Gambling; CESC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -5.7 -0.33 3.12e-8 Extrinsic epigenetic age acceleration; CESC cis rs7772486 0.686 rs4896828 chr6:145953339 A/C cg23711669 chr6:146136114 FBXO30 0.91 13.45 0.64 8.62e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs9457247 0.508 rs6902119 chr6:167505791 T/C cg23791538 chr6:167370224 RNASET2 -0.45 -5.89 -0.34 1.2e-8 Crohn's disease; CESC cis rs6582630 0.502 rs8186661 chr12:38380781 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.62 0.38 2.03e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs73001065 0.818 rs12610191 chr19:19721976 C/T cg03709012 chr19:19516395 GATAD2A 0.96 6.02 0.35 5.77e-9 LDL cholesterol; CESC cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.84 7.22 0.41 5.45e-12 Initial pursuit acceleration; CESC cis rs2790457 0.958 rs2772433 chr10:28895946 A/G cg04045419 chr10:28823091 WAC 0.42 5.12 0.3 5.76e-7 Multiple myeloma; CESC cis rs9287719 0.935 rs6751075 chr2:10723546 C/G cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.35e-8 Prostate cancer; CESC cis rs7959452 0.718 rs10878963 chr12:69717166 T/G cg14784868 chr12:69753453 YEATS4 0.51 6.67 0.38 1.48e-10 Blood protein levels; CESC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg07648498 chr16:89883185 FANCA 0.43 5.37 0.31 1.69e-7 Vitiligo; CESC cis rs3820928 0.874 rs4461255 chr2:227846524 C/T cg11843606 chr2:227700838 RHBDD1 0.47 6.03 0.35 5.45e-9 Pulmonary function; CESC cis rs992157 0.710 rs12996912 chr2:219110555 A/G cg00012203 chr2:219082015 ARPC2 0.86 12.48 0.61 2.02e-28 Colorectal cancer; CESC cis rs4891159 0.790 rs17059325 chr18:74119567 A/C cg24786174 chr18:74118243 ZNF516 -0.61 -8.4 -0.46 2.67e-15 Longevity; CESC cis rs4969178 0.930 rs4580257 chr17:76403028 T/G cg20026190 chr17:76395443 PGS1 0.46 7.13 0.4 9.46e-12 HDL cholesterol levels; CESC cis rs950776 0.518 rs3813572 chr15:78832588 T/C cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.06e-7 Sudden cardiac arrest; CESC cis rs116095464 0.558 rs28729548 chr5:229025 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.69 0.33 3.34e-8 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04318602 chr14:53162623 ERO1L 0.55 6.01 0.35 6.04e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00892999 chr4:892055 GAK -0.51 -6.38 -0.36 7.99e-10 Gut microbiome composition (summer); CESC cis rs10857712 0.904 rs36118799 chr10:135222369 T/G cg01444801 chr10:135216882 MTG1 -0.47 -5.61 -0.33 5.02e-8 Systemic lupus erythematosus; CESC cis rs7640424 0.819 rs162070 chr3:107835448 G/A cg09227934 chr3:107805635 CD47 0.48 6.07 0.35 4.4e-9 Body mass index; CESC cis rs7580658 0.676 rs12465955 chr2:128007074 A/T cg10021288 chr2:128175891 PROC -0.37 -5.95 -0.34 8.36e-9 Protein C levels; CESC cis rs2832077 0.527 rs2142375 chr21:30223742 G/A cg24692254 chr21:30365293 RNF160 -0.66 -9.15 -0.49 1.56e-17 Cognitive test performance; CESC cis rs7927771 0.965 rs4752881 chr11:47898535 A/G cg20307385 chr11:47447363 PSMC3 -0.47 -5.63 -0.33 4.55e-8 Subjective well-being; CESC cis rs11229555 0.645 rs7947248 chr11:58197750 C/T cg15696309 chr11:58395628 NA -0.42 -5.05 -0.3 8.13e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs2710642 0.611 rs974345 chr2:62882774 C/T cg17519650 chr2:63277830 OTX1 0.44 5.26 0.31 2.91e-7 LDL cholesterol levels;LDL cholesterol; CESC trans rs208520 0.821 rs9363572 chr6:67012231 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.81 7.68 0.43 3.1400000000000003e-13 Exhaled nitric oxide output; CESC cis rs7208859 0.623 rs11658945 chr17:29122509 T/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11030122 0.645 rs11493482 chr11:4034772 A/G cg18678763 chr11:4115507 RRM1 -0.49 -6.63 -0.38 1.91e-10 Mean platelet volume;Platelet distribution width; CESC cis rs28374715 0.681 rs7165396 chr15:41586947 T/C cg20272979 chr15:41787780 ITPKA 0.43 5.11 0.3 6.18e-7 Ulcerative colitis; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg19598685 chr12:109592525 ACACB 0.49 6.13 0.35 3.2e-9 Psoriatic arthritis; CESC trans rs7944735 0.938 rs59185955 chr11:47961566 G/C cg15704280 chr7:45808275 SEPT13 0.61 6.28 0.36 1.35e-9 Intraocular pressure; CESC cis rs17601876 0.843 rs6493494 chr15:51549835 G/A cg19946085 chr15:51559439 CYP19A1 -0.33 -5.15 -0.3 5.14e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs1707322 1.000 rs11211219 chr1:46359478 G/C cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs965469 0.947 rs7274193 chr20:3329750 C/T cg25506879 chr20:3388711 C20orf194 -0.54 -5.78 -0.33 2.14e-8 IFN-related cytopenia; CESC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg15445000 chr17:37608096 MED1 0.4 6.38 0.36 7.97e-10 Glomerular filtration rate (creatinine); CESC trans rs1977584 0.725 rs76416597 chr10:45396081 A/G cg09262100 chr14:103416268 CDC42BPB 0.61 6.14 0.35 3.02e-9 Selective IgA deficiency; CESC cis rs7927771 0.931 rs12361256 chr11:47910823 A/C cg20307385 chr11:47447363 PSMC3 -0.43 -5.49 -0.32 9.32e-8 Subjective well-being; CESC cis rs7223966 1.000 rs2854223 chr17:61939014 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.47 -5.86 -0.34 1.34e-8 Hip circumference adjusted for BMI;Body mass index; CESC trans rs6480314 0.522 rs10047355 chr10:70060078 C/T cg04882175 chr6:131122610 NA -0.65 -6.07 -0.35 4.31e-9 Optic nerve measurement (disc area); CESC cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg13628971 chr7:2884303 GNA12 0.42 5.68 0.33 3.5e-8 Height; CESC cis rs6121246 0.609 rs6060652 chr20:30266845 A/G cg13852791 chr20:30311386 BCL2L1 0.75 9.61 0.51 6.08e-19 Mean corpuscular hemoglobin; CESC cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg19626725 chr5:178986131 RUFY1 0.39 6.37 0.36 8.51e-10 Lung cancer; CESC cis rs3126085 0.825 rs10788830 chr1:152206898 A/C cg03465714 chr1:152285911 FLG -0.42 -5.07 -0.3 7.3e-7 Atopic dermatitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08845439 chr1:151512945 TUFT1 0.54 6.14 0.35 2.96e-9 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg26314531 chr2:26401878 FAM59B -0.62 -7.07 -0.4 1.37e-11 Gut microbiome composition (summer); CESC cis rs2249694 0.537 rs9418988 chr10:135327632 C/T cg20169779 chr10:135381914 SYCE1 0.4 5.35 0.31 1.88e-7 Obesity-related traits; CESC cis rs9549367 0.826 rs2287249 chr13:113889355 A/G cg18105134 chr13:113819100 PROZ -0.65 -7.73 -0.43 2.24e-13 Platelet distribution width; CESC trans rs1814175 0.616 rs1794139 chr11:49910855 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.6 -0.75 5.48e-50 Height; CESC cis rs1707322 0.963 rs1768815 chr1:46528603 G/A cg05343316 chr1:45956843 TESK2 -0.43 -5.18 -0.3 4.37e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs713587 0.566 rs497567 chr2:25335089 G/A cg01884057 chr2:25150051 NA -0.3 -5.21 -0.3 3.89e-7 Body mass index in non-asthmatics; CESC cis rs644799 1.000 rs623191 chr11:95548359 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs5763662 1.000 rs5753015 chr22:30517325 G/A cg21388335 chr22:29999516 NF2 -0.79 -5.14 -0.3 5.3e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs2072732 0.756 rs55949537 chr1:2936746 A/T cg15211996 chr1:2936768 ACTRT2 0.34 5.51 0.32 8.71e-8 Plateletcrit; CESC cis rs62064224 0.614 rs6505294 chr17:30687415 C/T cg18200150 chr17:30822561 MYO1D 0.39 5.05 0.3 8.22e-7 Schizophrenia; CESC trans rs2472476 0.900 rs10820722 chr9:107517680 G/T cg14553338 chr2:66689807 MEIS1 0.42 6.09 0.35 3.95e-9 Obesity-related traits; CESC cis rs9902453 0.967 rs55748380 chr17:28469782 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 8.01 0.44 3.58e-14 Coffee consumption (cups per day); CESC cis rs7726839 0.555 rs4541696 chr5:581053 A/G cg16447950 chr5:562315 NA -0.47 -6.99 -0.39 2.26e-11 Obesity-related traits; CESC cis rs6987853 0.563 rs2974301 chr8:42442238 A/G cg09913449 chr8:42400586 C8orf40 0.32 5.03 0.3 8.93e-7 Mean corpuscular hemoglobin concentration; CESC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg20271620 chr17:80763330 TBCD 0.46 5.33 0.31 2.06e-7 Breast cancer; CESC cis rs6987853 0.749 rs13250124 chr8:42404737 G/A cg09913449 chr8:42400586 C8orf40 0.45 7.6 0.42 5.18e-13 Mean corpuscular hemoglobin concentration; CESC cis rs2204008 0.775 rs3900361 chr12:38238936 A/G cg13010199 chr12:38710504 ALG10B -0.48 -5.91 -0.34 1.04e-8 Bladder cancer; CESC cis rs863345 0.604 rs10797011 chr1:158465371 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs684232 0.666 rs425961 chr17:573714 G/A cg15660573 chr17:549704 VPS53 -0.64 -8.84 -0.48 1.35e-16 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14838070 chr5:150030486 SYNPO -0.54 -6.13 -0.35 3.25e-9 Gut microbiome composition (summer); CESC cis rs6460942 0.659 rs17192500 chr7:12545379 A/G cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg16405210 chr4:1374714 KIAA1530 0.45 5.59 0.32 5.7e-8 Obesity-related traits; CESC cis rs11098499 0.954 rs3890049 chr4:120326283 T/A cg24375607 chr4:120327624 NA 0.48 5.93 0.34 9.24e-9 Corneal astigmatism; CESC cis rs7937682 0.924 rs7938360 chr11:111539875 A/G cg09085632 chr11:111637200 PPP2R1B -0.99 -16.23 -0.71 1.37e-41 Primary sclerosing cholangitis; CESC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.26e-11 Skin colour saturation; CESC cis rs7631605 0.905 rs60490177 chr3:37254925 G/C cg22985146 chr3:37219077 LRRFIP2 -0.36 -5.75 -0.33 2.46e-8 Cerebrospinal P-tau181p levels; CESC cis rs2072499 0.750 rs55675376 chr1:156165881 C/T cg24450063 chr1:156163899 SLC25A44 0.97 12.22 0.6 1.54e-27 Testicular germ cell tumor; CESC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg04944784 chr2:26401820 FAM59B -0.79 -8.83 -0.48 1.42e-16 Gut microbiome composition (summer); CESC cis rs4319547 0.695 rs1973463 chr12:122938003 A/G cg05707623 chr12:122985044 ZCCHC8 -0.51 -5.99 -0.35 6.95e-9 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05947499 chr12:113704091 TPCN1 -0.71 -7.93 -0.44 6.16e-14 Gut microbiome composition (summer); CESC cis rs7605827 0.897 rs7590963 chr2:15527888 T/C cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs941873 0.838 rs2233713 chr10:81107135 A/C cg11057378 chr10:81107060 PPIF 0.37 5.87 0.34 1.31e-8 Height; CESC cis rs12701220 0.553 rs34062359 chr7:1139076 C/T cg26769984 chr7:1090371 C7orf50 0.61 6.31 0.36 1.17e-9 Bronchopulmonary dysplasia; CESC cis rs9633740 0.773 rs1870148 chr10:82271341 G/A cg00277334 chr10:82204260 NA -0.55 -5.51 -0.32 8.63e-8 Post bronchodilator FEV1; CESC cis rs2235642 0.601 rs2235647 chr16:1601331 C/A cg03771183 chr16:1608904 IFT140 0.38 5.39 0.31 1.53e-7 Coronary artery disease; CESC cis rs2991971 0.729 rs10890328 chr1:45905383 G/T cg05343316 chr1:45956843 TESK2 0.59 8.52 0.46 1.23e-15 High light scatter reticulocyte count; CESC cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg05347473 chr6:146136440 FBXO30 -0.57 -7.34 -0.41 2.62e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs17376456 0.542 rs1453003 chr5:93151611 T/C cg21475434 chr5:93447410 FAM172A -0.5 -5.11 -0.3 6.26e-7 Diabetic retinopathy; CESC cis rs6582630 0.519 rs11495376 chr12:38284957 A/C cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs17253792 0.822 rs75763956 chr14:56071176 A/G cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs12541635 0.966 rs62525736 chr8:107000638 G/C cg10147462 chr8:107024639 NA 0.41 5.68 0.33 3.6e-8 Age of smoking initiation; CESC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg18110333 chr6:292329 DUSP22 -0.75 -10.21 -0.53 7.28e-21 Menopause (age at onset); CESC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg17971929 chr21:40555470 PSMG1 -0.88 -12.57 -0.61 9.49e-29 Cognitive function; CESC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.61e-9 Prudent dietary pattern; CESC cis rs9811920 0.638 rs2452321 chr3:99638836 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.61 9.74 0.51 2.34e-19 Axial length; CESC cis rs17384381 1.000 rs1608536 chr1:85885836 C/T cg16011679 chr1:85725395 C1orf52 0.73 7.51 0.42 8.79e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs3020736 0.500 rs7364293 chr22:42506370 C/T cg15557168 chr22:42548783 NA 0.45 6.3 0.36 1.25e-9 Autism spectrum disorder or schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24028381 chr8:145133668 EXOSC4 0.44 6.17 0.35 2.6e-9 Gut microbiota (bacterial taxa); CESC cis rs2658782 0.951 rs117384439 chr11:93111478 T/G cg15737290 chr11:93063684 CCDC67 -0.52 -6.49 -0.37 4.29e-10 Pulmonary function decline; CESC cis rs4819052 0.679 rs2838860 chr21:46684904 A/G cg11663144 chr21:46675770 NA -0.43 -6.55 -0.37 2.93e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9303280 0.719 rs56750287 chr17:38062944 A/C cg19468946 chr17:37922297 IKZF3 -0.4 -5.22 -0.31 3.64e-7 Self-reported allergy; CESC cis rs1670533 1.000 rs13107058 chr4:1054379 G/A cg27284194 chr4:1044797 NA 0.46 5.83 0.34 1.61e-8 Recombination rate (females); CESC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg04369109 chr6:150039330 LATS1 -0.42 -5.95 -0.34 8.52e-9 Lung cancer; CESC cis rs7927771 1.000 rs10838757 chr11:47763016 T/C cg05585544 chr11:47624801 NA -0.51 -7.99 -0.44 4.28e-14 Subjective well-being; CESC cis rs965469 0.947 rs6037529 chr20:3261006 C/T cg25506879 chr20:3388711 C20orf194 -0.57 -6.12 -0.35 3.26e-9 IFN-related cytopenia; CESC cis rs11711311 1.000 rs13070720 chr3:113473754 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.59 7.78 0.43 1.58e-13 IgG glycosylation; CESC cis rs7727544 0.684 rs2631363 chr5:131707095 A/G cg07395648 chr5:131743802 NA 0.39 5.14 0.3 5.25e-7 Blood metabolite levels; CESC cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs15676 0.783 rs7033070 chr9:131586374 G/A cg00228799 chr9:131580591 ENDOG -0.54 -6.74 -0.38 9.81e-11 Blood metabolite levels; CESC cis rs6693567 0.516 rs7554686 chr1:150265619 A/T cg09579323 chr1:150459698 TARS2 -0.47 -6.02 -0.35 5.87e-9 Migraine; CESC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 23.37 0.82 2.54e-66 Prudent dietary pattern; CESC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg19626725 chr5:178986131 RUFY1 0.33 5.05 0.3 8.35e-7 Lung cancer; CESC cis rs6973256 0.637 rs12707116 chr7:133424909 C/T cg10665199 chr7:133106180 EXOC4 -0.41 -5.66 -0.33 3.84e-8 Intelligence (multi-trait analysis); CESC cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg02297831 chr4:17616191 MED28 0.59 7.26 0.41 4.36e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg11987759 chr7:65425863 GUSB -0.49 -6.43 -0.37 6.06e-10 Aortic root size; CESC cis rs2439831 0.850 rs16977798 chr15:44151948 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.58 5.14 0.3 5.39e-7 Lung cancer in ever smokers; CESC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg11890956 chr21:40555474 PSMG1 1.17 21.82 0.8 4.14e-61 Cognitive function; CESC cis rs6032067 1.000 rs6017526 chr20:43871555 A/T cg10761708 chr20:43804764 PI3 0.52 6.19 0.36 2.24e-9 Blood protein levels; CESC cis rs6987853 0.830 rs4361746 chr8:42355041 C/T cg09913449 chr8:42400586 C8orf40 -0.34 -5.3 -0.31 2.41e-7 Mean corpuscular hemoglobin concentration; CESC cis rs7208859 0.673 rs9911989 chr17:29237702 A/C cg19761014 chr17:28927070 LRRC37B2 -0.76 -5.92 -0.34 1.02e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg13902645 chr11:5959945 NA 0.74 10.62 0.55 3.41e-22 DNA methylation (variation); CESC cis rs9486719 1.000 rs3798289 chr6:97023632 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -8.28 -0.45 6.29e-15 Migraine;Coronary artery disease; CESC cis rs6496667 1.000 rs6496669 chr15:90895265 A/G cg22089800 chr15:90895588 ZNF774 -0.55 -5.27 -0.31 2.86e-7 Rheumatoid arthritis; CESC cis rs6424115 0.830 rs2503002 chr1:24196957 C/G cg15997130 chr1:24165203 NA 0.39 5.25 0.31 3.05e-7 Immature fraction of reticulocytes; CESC cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg06697600 chr4:7070879 GRPEL1 -0.48 -7.14 -0.4 9.16e-12 Monocyte percentage of white cells; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg11768411 chr8:144329279 ZFP41 0.52 6.06 0.35 4.55e-9 Psoriatic arthritis; CESC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg07677032 chr17:61819896 STRADA 0.46 6.4 0.37 7.02e-10 Prudent dietary pattern; CESC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.71e-16 Initial pursuit acceleration; CESC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg02569458 chr12:86230093 RASSF9 0.57 8.27 0.45 6.76e-15 Major depressive disorder; CESC cis rs2204008 0.659 rs4002655 chr12:38169881 T/G cg13010199 chr12:38710504 ALG10B 0.52 6.6 0.38 2.18e-10 Bladder cancer; CESC trans rs9929218 0.817 rs3114399 chr16:68713385 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -8.59 -0.47 7.81e-16 Colorectal cancer; CESC cis rs4853012 0.838 rs2177707 chr2:74356850 A/G cg05776053 chr2:74358815 NA 0.43 5.07 0.3 7.45e-7 Gestational age at birth (maternal effect); CESC cis rs11098499 0.874 rs6826823 chr4:120112098 G/C cg09307838 chr4:120376055 NA 0.67 8.32 0.45 4.79e-15 Corneal astigmatism; CESC cis rs72627509 0.951 rs6554401 chr4:57825336 C/G cg26694713 chr4:57773883 REST 0.58 5.62 0.33 4.85e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9858542 1.000 rs11718165 chr3:49696797 A/G cg07274523 chr3:49395745 GPX1 0.66 8.24 0.45 7.92e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7072216 0.763 rs10732782 chr10:100166506 C/A cg26618903 chr10:100175079 PYROXD2 -0.36 -5.49 -0.32 9.42e-8 Metabolite levels; CESC cis rs42648 0.869 rs6973816 chr7:89921072 C/T cg23697855 chr7:89950296 NA 0.28 5.45 0.32 1.17e-7 Homocysteine levels; CESC cis rs3743266 0.507 rs11637887 chr15:60765216 C/T cg22293140 chr15:60689852 ANXA2 -0.7 -7.37 -0.41 2.12e-12 Menarche (age at onset); CESC cis rs3806843 1.000 rs4151682 chr5:140201264 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.15 -0.3 4.97e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg00166722 chr3:10149974 C3orf24 0.46 5.72 0.33 2.8e-8 Alzheimer's disease; CESC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg07507251 chr3:52567010 NT5DC2 0.43 7.43 0.41 1.54e-12 Bipolar disorder; CESC cis rs16948098 1 rs16948098 chr15:44219607 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.61 5.07 0.3 7.6e-7 Serum albumin level; CESC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg23161317 chr6:28129485 ZNF389 0.45 5.92 0.34 9.82e-9 Depression; CESC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg02931644 chr1:25747376 RHCE 0.39 6.44 0.37 5.7e-10 Erythrocyte sedimentation rate; CESC cis rs1062177 0.756 rs2915815 chr5:151115883 G/C cg00977110 chr5:151150581 G3BP1 -0.61 -6.36 -0.36 9e-10 Preschool internalizing problems; CESC trans rs7937682 0.924 rs875258 chr11:111530607 C/A cg18187862 chr3:45730750 SACM1L 0.48 6.08 0.35 4.15e-9 Primary sclerosing cholangitis; CESC cis rs7851660 0.809 rs7036589 chr9:100657720 A/T cg13688889 chr9:100608707 NA 0.63 8.84 0.48 1.4e-16 Strep throat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04416821 chr6:43477544 C6orf154 0.58 6.1 0.35 3.71e-9 Gut microbiome composition (summer); CESC cis rs478304 0.651 rs948493 chr11:65552154 C/T cg10518572 chr11:65560635 OVOL1 -0.31 -5.76 -0.33 2.37e-8 Acne (severe); CESC cis rs11997175 0.624 rs17701219 chr8:33728795 T/A ch.8.33884649F chr8:33765107 NA 0.56 7.32 0.41 3.02e-12 Body mass index; CESC cis rs2243480 1.000 rs937108 chr7:65428452 G/A cg12463550 chr7:65579703 CRCP 0.67 5.52 0.32 8.15e-8 Diabetic kidney disease; CESC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg20887711 chr4:1340912 KIAA1530 -0.66 -8.85 -0.48 1.29e-16 Obesity-related traits; CESC cis rs116095464 0.558 rs62346506 chr5:201594 T/C cg16372103 chr5:203701 NA 0.51 5.7 0.33 3.12e-8 Breast cancer; CESC cis rs1707322 1.000 rs785493 chr1:46584859 A/G cg06784218 chr1:46089804 CCDC17 -0.36 -5.93 -0.34 9.35e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.24 0.63 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs858239 0.636 rs7808488 chr7:23221870 T/C cg23682824 chr7:23144976 KLHL7 0.43 5.74 0.33 2.59e-8 Cerebrospinal fluid biomarker levels; CESC cis rs2294693 0.786 rs10456497 chr6:40989057 T/C cg14769373 chr6:40998127 UNC5CL -0.44 -5.41 -0.32 1.44e-7 Gastric cancer;Non-cardia gastric cancer; CESC trans rs7246760 1.000 rs28441975 chr19:9897631 C/A cg02900749 chr2:68251473 NA -0.74 -6.84 -0.39 5.62e-11 Pursuit maintenance gain; CESC cis rs11997175 0.670 rs34985841 chr8:33661889 C/A ch.8.33884649F chr8:33765107 NA 0.68 8.78 0.47 2.13e-16 Body mass index; CESC cis rs7586673 0.866 rs7579662 chr2:161915810 G/A cg16506815 chr2:162101123 NA 0.43 5.8 0.34 1.86e-8 Intelligence (multi-trait analysis); CESC cis rs9488822 0.636 rs1544155 chr6:116346394 C/A cg15226275 chr6:116381976 FRK 0.26 6.48 0.37 4.43e-10 Cholesterol, total;LDL cholesterol; CESC cis rs17102423 0.692 rs762810 chr14:65544367 C/A cg11161011 chr14:65562177 MAX -0.48 -5.38 -0.31 1.61e-7 Obesity-related traits; CESC cis rs2806561 0.929 rs9426694 chr1:23539742 T/C cg12483005 chr1:23474871 LUZP1 0.33 5.2 0.3 4.01e-7 Height; CESC cis rs7267979 1.000 rs6050565 chr20:25347563 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -17.91 -0.74 1.5e-47 Liver enzyme levels (alkaline phosphatase); CESC cis rs8017423 1.000 rs4900028 chr14:90685594 C/T cg14092571 chr14:90743983 NA -0.58 -8.72 -0.47 3.19e-16 Mortality in heart failure; CESC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.44 0.37 5.5e-10 Prudent dietary pattern; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01140579 chr3:48541502 SHISA5 -0.48 -6.52 -0.37 3.56e-10 Ulcerative colitis; CESC cis rs921968 0.509 rs556468 chr2:219355794 G/A cg02176678 chr2:219576539 TTLL4 0.5 8.98 0.48 5.22e-17 Mean corpuscular hemoglobin concentration; CESC cis rs7267979 1.000 rs2482919 chr20:25299756 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.08 -0.7 4.65e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs9457247 0.967 rs2149092 chr6:167372978 C/T cg25258033 chr6:167368657 RNASET2 -0.41 -6.2 -0.36 2.17e-9 Crohn's disease; CESC cis rs7827545 1.000 rs1372662 chr8:135567046 C/G cg17885191 chr8:135476712 NA 0.48 6.46 0.37 5.03e-10 Hypertension (SNP x SNP interaction); CESC cis rs6691722 0.506 rs12030365 chr1:24739220 T/A cg18323236 chr1:24743029 NIPAL3 0.48 7.36 0.41 2.3e-12 Response to interferon beta in multiple sclerosis; CESC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg17971929 chr21:40555470 PSMG1 1.06 16.26 0.71 1.02e-41 Cognitive function; CESC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg13114125 chr14:105738426 BRF1 -0.82 -10.21 -0.53 7.24e-21 Mean platelet volume;Platelet distribution width; CESC cis rs10911251 0.528 rs10911248 chr1:183080564 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 13.96 0.65 1.41e-33 Colorectal cancer; CESC cis rs9443189 0.950 rs6938349 chr6:76484280 A/T cg01950844 chr6:76311363 SENP6 0.63 6.44 0.37 5.69e-10 Prostate cancer; CESC cis rs17376456 0.877 rs7734897 chr5:93305402 G/A cg25358565 chr5:93447407 FAM172A 1.07 10.7 0.55 1.86e-22 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07755343 chr16:1712697 CRAMP1L -0.57 -6.79 -0.38 7.3e-11 Gut microbiome composition (summer); CESC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.56 0.37 2.76e-10 Bipolar disorder; CESC cis rs473651 0.935 rs482775 chr2:239335403 G/C cg21699342 chr2:239360505 ASB1 0.54 9.26 0.49 7.3e-18 Multiple system atrophy; CESC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC trans rs72766638 0.848 rs11789898 chr9:136925663 A/C cg10765909 chr12:53715428 AAAS 0.6 6.06 0.35 4.62e-9 Mosquito bite size; CESC cis rs7208859 0.623 rs73267858 chr17:29059737 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7178572 0.889 rs7170877 chr15:77832019 C/G cg22256960 chr15:77711686 NA -0.52 -7.12 -0.4 9.94e-12 Type 2 diabetes; CESC cis rs36051895 0.659 rs62541539 chr9:5038180 C/T cg02405213 chr9:5042618 JAK2 -0.48 -5.77 -0.33 2.2e-8 Pediatric autoimmune diseases; CESC trans rs11039798 0.591 rs74992349 chr11:49019252 G/A cg15704280 chr7:45808275 SEPT13 0.67 6.71 0.38 1.16e-10 Axial length; CESC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.753 rs13122897 chr4:98936185 C/A cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs11958404 0.615 rs6556333 chr5:157445659 T/C cg05962755 chr5:157440814 NA 0.38 5.67 0.33 3.75e-8 IgG glycosylation; CESC cis rs7243790 0.805 rs62091574 chr18:51939063 C/A cg04730925 chr18:51795821 POLI -0.43 -5.75 -0.33 2.4e-8 Diastolic blood pressure; CESC cis rs3782089 0.546 rs76146604 chr11:65277512 G/T cg21890820 chr11:65308645 LTBP3 1.12 8.53 0.46 1.13e-15 Height; CESC cis rs9303401 0.659 rs17741087 chr17:56550300 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.99 12.3 0.6 8.24e-28 Cognitive test performance; CESC trans rs35110281 0.748 rs162403 chr21:44963365 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 7.37 0.41 2.13e-12 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02678462 chr19:5154735 NA -0.64 -7.27 -0.41 4.1e-12 Gut microbiome composition (summer); CESC cis rs9308731 0.623 rs11674517 chr2:111903832 C/T cg04202892 chr2:111875749 ACOXL 0.44 6.15 0.35 2.92e-9 Chronic lymphocytic leukemia; CESC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg14829155 chr15:31115871 NA 0.74 10.59 0.55 4.45e-22 Huntington's disease progression; CESC cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg20891283 chr12:69753455 YEATS4 0.9 15.06 0.68 1.92e-37 Blood protein levels; CESC cis rs6736093 0.932 rs7595212 chr2:112662767 A/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.17 -0.3 4.56e-7 Coronary artery disease; CESC trans rs6089829 0.962 rs6122347 chr20:61661866 C/T cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs7089973 0.604 rs11196939 chr10:116593175 A/G cg25233709 chr10:116636983 FAM160B1 -0.36 -5.6 -0.33 5.42e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs96067 0.805 rs3767705 chr1:36602044 A/T cg24686825 chr1:36642396 MAP7D1 -0.46 -5.38 -0.31 1.63e-7 Corneal structure; CESC cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg16743903 chr16:89593216 SPG7 -0.42 -5.32 -0.31 2.19e-7 Multiple myeloma (IgH translocation); CESC cis rs11122272 0.735 rs2749707 chr1:231527316 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.7 -0.43 2.63e-13 Hemoglobin concentration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23819836 chr6:15663134 DTNBP1 -0.43 -6.19 -0.36 2.23e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3733585 0.598 rs28677023 chr4:9958326 C/A cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08543242 chr3:45017843 ZDHHC3;EXOSC7 0.57 6.68 0.38 1.41e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03369668 chr7:2578307 C7orf27 0.47 6.52 0.37 3.52e-10 Fibrinogen levels; CESC cis rs2522056 1.000 rs2706379 chr5:131805735 C/T cg24060327 chr5:131705240 SLC22A5 0.61 6.93 0.39 3.22e-11 Lymphocyte counts;Fibrinogen; CESC cis rs10911251 0.528 rs6669199 chr1:183082421 C/A ch.1.3577855R chr1:183094577 LAMC1 0.87 14.12 0.66 3.98e-34 Colorectal cancer; CESC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 8.33 0.46 4.25e-15 Platelet count; CESC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg06028808 chr11:68637592 NA 0.4 5.06 0.3 7.67e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1499614 0.901 rs3936 chr7:66126489 C/T cg12463550 chr7:65579703 CRCP 0.74 5.71 0.33 3.03e-8 Gout; CESC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.31 -5.14 -0.3 5.46e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs2832191 0.791 rs2832187 chr21:30485543 T/C cg08807101 chr21:30365312 RNF160 -0.77 -11.23 -0.57 3.52e-24 Dental caries; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13319975 chr6:146136371 FBXO30 0.58 7.03 0.4 1.79e-11 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC cis rs9858542 1.000 rs9822268 chr3:49719729 G/A cg07274523 chr3:49395745 GPX1 0.67 8.65 0.47 5.08e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9457247 0.967 rs1590257 chr6:167377782 G/T cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.62e-7 Crohn's disease; CESC cis rs722599 0.748 rs1059326 chr14:75369385 C/T cg08847533 chr14:75593920 NEK9 -0.47 -5.62 -0.33 4.89e-8 IgG glycosylation; CESC cis rs6831352 0.703 rs2602862 chr4:100033221 A/G cg12011299 chr4:100065546 ADH4 0.57 6.88 0.39 4.34e-11 Alcohol dependence; CESC cis rs72781680 0.898 rs17509001 chr2:24021231 T/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs17039065 0.920 rs58451659 chr4:109446003 T/C cg16022748 chr4:109541635 LOC285456;RPL34 0.62 5.61 0.33 5.08e-8 Gut microbiome composition (summer); CESC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg27211696 chr2:191398769 TMEM194B 0.52 7.62 0.42 4.53e-13 Pulse pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00081019 chr1:243658800 SDCCAG8;AKT3 0.51 7.02 0.4 1.82e-11 Fibrinogen levels; CESC trans rs7335046 1.000 rs3759444 chr13:99910263 C/T cg14259717 chr11:18433732 LDHC 0.6 6.05 0.35 4.97e-9 Basal cell carcinoma; CESC cis rs1348850 0.526 rs1345138 chr2:178387100 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.69 6.19 0.36 2.22e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs963731 0.522 rs297148 chr2:39323166 A/G cg04010122 chr2:39346883 SOS1 -0.74 -5.39 -0.31 1.54e-7 Corticobasal degeneration; CESC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg00310523 chr12:86230176 RASSF9 0.33 5.18 0.3 4.47e-7 Major depressive disorder; CESC cis rs9902453 0.765 rs2729440 chr17:28106874 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 11.36 0.57 1.25e-24 Platelet count; CESC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg26338869 chr17:61819248 STRADA 0.69 9.11 0.49 2.04e-17 Prudent dietary pattern; CESC cis rs1461503 0.966 rs10790547 chr11:122842110 T/A cg27398637 chr11:122830231 C11orf63 -0.55 -8.23 -0.45 8.8e-15 Menarche (age at onset); CESC cis rs1707322 1.000 rs11211219 chr1:46359478 G/C cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9815354 0.812 rs111277902 chr3:41950312 C/T cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.9e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21956150 chr19:1438388 RPS15 0.56 6.87 0.39 4.65e-11 Gut microbiome composition (summer); CESC cis rs4664304 0.772 rs17830558 chr2:160878364 A/C cg03641300 chr2:160917029 PLA2R1 -0.47 -6.63 -0.38 1.83e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs35110281 0.782 rs2051407 chr21:45079245 T/C cg01579765 chr21:45077557 HSF2BP -0.56 -9.31 -0.5 4.98e-18 Mean corpuscular volume; CESC cis rs1707322 1.000 rs10890372 chr1:46391020 T/G cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs6951245 0.554 rs10270249 chr7:1151886 G/T cg13565492 chr6:43139072 SRF -0.74 -9.0 -0.48 4.53e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12190007 1.000 rs12211973 chr6:169727141 T/C cg16388071 chr6:169726476 NA -0.42 -5.71 -0.33 2.99e-8 Obesity-related traits; CESC cis rs763121 0.853 rs9610993 chr22:39042818 C/A cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs36051895 0.632 rs10118789 chr9:5141178 G/A cg02405213 chr9:5042618 JAK2 -0.51 -6.12 -0.35 3.36e-9 Pediatric autoimmune diseases; CESC cis rs72772090 0.539 rs10515248 chr5:96112005 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.05 -0.3 8.29e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg26677194 chr12:130822605 PIWIL1 0.52 6.81 0.39 6.58e-11 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21403912 chr1:155239301 CLK2 0.44 6.11 0.35 3.47e-9 Fibrinogen levels; CESC trans rs17428076 0.831 rs55957712 chr2:172587956 C/T cg16863673 chr2:240905040 NDUFA10 0.54 6.13 0.35 3.15e-9 Myopia; CESC cis rs9858542 0.953 rs6809216 chr3:49412559 G/A cg03060546 chr3:49711283 APEH -0.54 -6.16 -0.35 2.67e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs34779708 0.966 rs12769484 chr10:35465746 G/A cg04310649 chr10:35416472 CREM -0.53 -6.49 -0.37 4.32e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs644799 0.965 rs602512 chr11:95561682 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.13 0.49 1.83e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9457247 1.000 rs444988 chr6:167389674 A/T cg07741184 chr6:167504864 NA 0.3 5.52 0.32 8.14e-8 Crohn's disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg00894870 chr1:19578612 MRTO4;KIAA0090 0.51 6.88 0.39 4.3e-11 Systemic lupus erythematosus; CESC cis rs16854884 0.657 rs35309714 chr3:143735011 T/A cg06585982 chr3:143692056 C3orf58 0.5 6.56 0.37 2.84e-10 Economic and political preferences (feminism/equality); CESC cis rs12618769 0.656 rs3820943 chr2:99123177 G/C cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06156157 chr1:47799348 CMPK1 0.51 6.64 0.38 1.8e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7605827 0.930 rs7593184 chr2:15598461 T/G cg19274914 chr2:15703543 NA 0.33 5.82 0.34 1.73e-8 Educational attainment (years of education); CESC cis rs965469 0.652 rs4507156 chr20:3228460 A/G cg25506879 chr20:3388711 C20orf194 0.54 6.28 0.36 1.37e-9 IFN-related cytopenia; CESC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.33 -0.31 2.13e-7 Lung cancer; CESC cis rs1178121 0.517 rs12540265 chr7:18830464 A/G cg12955305 chr7:19759345 TMEM196 -0.41 -5.05 -0.3 8.38e-7 Systemic juvenile idiopathic arthritis; CESC cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg18016565 chr1:150552671 MCL1 -0.36 -5.98 -0.34 7.07e-9 Tonsillectomy; CESC cis rs1348850 0.632 rs12616288 chr2:178503813 G/T cg22681709 chr2:178499509 PDE11A -0.56 -8.6 -0.47 7.16e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7408868 0.831 rs11672004 chr19:15277282 T/A cg14696996 chr19:15285081 NOTCH3 0.85 9.39 0.5 2.95e-18 Pulse pressure; CESC cis rs2742234 0.541 rs11238476 chr10:43711436 G/T cg15436174 chr10:43711423 RASGEF1A 0.47 5.53 0.32 7.48e-8 Hirschsprung disease; CESC trans rs17685 0.753 rs4398845 chr7:75716781 G/A cg19862616 chr7:65841803 NCRNA00174 0.84 12.06 0.6 5.65e-27 Coffee consumption;Coffee consumption (cups per day); CESC cis rs910316 0.737 rs175071 chr14:75498177 A/G cg11812906 chr14:75593930 NEK9 -0.8 -13.09 -0.63 1.5e-30 Height; CESC cis rs7312933 0.703 rs2406567 chr12:42551479 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.47 6.17 0.35 2.48e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs2549003 0.933 rs3846731 chr5:131814264 T/C cg02551604 chr5:131831745 NA -0.36 -5.08 -0.3 7.22e-7 Asthma (sex interaction); CESC cis rs11658309 1 rs11658309 chr17:17762247 T/G cg04398451 chr17:18023971 MYO15A 0.64 9.39 0.5 2.84e-18 Strep throat; CESC trans rs1814175 0.647 rs61306292 chr11:49856040 G/C cg15704280 chr7:45808275 SEPT13 -1.04 -21.01 -0.79 2.32e-58 Height; CESC cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg26874164 chr19:58962979 ZNF324B 0.59 8.24 0.45 8.08e-15 Uric acid clearance; CESC cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg17366294 chr4:99064904 C4orf37 0.56 7.57 0.42 6.31e-13 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg02935154 chr7:12443704 VWDE -0.61 -6.93 -0.39 3.11e-11 Coronary artery disease; CESC cis rs12986413 0.967 rs2108524 chr19:2170764 A/G cg09261902 chr19:2140048 AP3D1 0.32 5.08 0.3 7.19e-7 Height; CESC trans rs11621135 0.594 rs8023180 chr14:71683412 C/T cg19986472 chr17:41561315 DHX8 -0.45 -6.02 -0.35 5.95e-9 Hair greying; CESC cis rs2635047 0.638 rs12953864 chr18:44625245 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.56 0.32 6.6e-8 Educational attainment; CESC cis rs155076 0.666 rs9509640 chr13:21872880 T/C cg06138931 chr13:21896616 NA 0.5 5.16 0.3 4.84e-7 White matter hyperintensity burden; CESC cis rs6580649 0.941 rs4760614 chr12:48427884 A/G cg24011408 chr12:48396354 COL2A1 -0.41 -5.2 -0.3 3.93e-7 Lung cancer; CESC cis rs863345 0.967 rs863357 chr1:158544253 C/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.46 -0.37 5.08e-10 Pneumococcal bacteremia; CESC cis rs6594499 0.872 rs1379298 chr5:110435726 T/C cg04022379 chr5:110408740 TSLP 0.33 5.9 0.34 1.11e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs2070677 0.935 rs12255182 chr10:135404096 G/A cg20169779 chr10:135381914 SYCE1 -0.77 -9.97 -0.52 4.29e-20 Gout; CESC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg12963246 chr6:28129442 ZNF389 0.42 5.86 0.34 1.34e-8 Cardiac Troponin-T levels; CESC cis rs637571 0.522 rs556643 chr11:65733289 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.71 10.13 0.53 1.31e-20 Eosinophil percentage of white cells; CESC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg22800045 chr5:56110881 MAP3K1 0.68 8.5 0.46 1.44e-15 Initial pursuit acceleration; CESC cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs8017423 0.647 rs12882973 chr14:90820502 G/A cg14092571 chr14:90743983 NA 0.43 6.55 0.37 2.91e-10 Mortality in heart failure; CESC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg00166722 chr3:10149974 C3orf24 0.53 6.52 0.37 3.49e-10 Alzheimer's disease; CESC cis rs6570726 0.935 rs7757387 chr6:145816726 G/T cg23711669 chr6:146136114 FBXO30 0.77 11.32 0.57 1.74e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs826838 0.967 rs7136593 chr12:39128265 C/T cg26384229 chr12:38710491 ALG10B -0.67 -11.01 -0.56 1.82e-23 Heart rate; CESC cis rs11864453 0.826 rs9941087 chr16:72118324 G/A cg16558253 chr16:72132732 DHX38 -0.56 -8.57 -0.47 8.5e-16 Fibrinogen levels; CESC cis rs116095464 0.558 rs6878061 chr5:223072 A/G cg10591111 chr5:226296 SDHA -0.51 -6.35 -0.36 9.22e-10 Breast cancer; CESC cis rs3750965 0.959 rs3168115 chr11:68858090 A/T cg01403660 chr11:68851641 TPCN2 -0.39 -5.29 -0.31 2.6e-7 Hair color; CESC cis rs12121840 0.790 rs7533908 chr1:165519700 T/C cg16553119 chr1:165599451 MGST3 -0.46 -5.22 -0.31 3.69e-7 Interleukin-1-receptor antagonist levels; CESC trans rs208520 0.909 rs62414636 chr6:67015723 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.81 7.68 0.43 3.1400000000000003e-13 Exhaled nitric oxide output; CESC cis rs1775715 0.737 rs2799000 chr10:32124894 C/T cg18675610 chr10:32216311 ARHGAP12 0.34 5.23 0.31 3.36e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6977955 0.838 rs2189966 chr7:28172066 C/T cg23620719 chr7:28220237 JAZF1 -0.5 -5.51 -0.32 8.61e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg23711669 chr6:146136114 FBXO30 -1.04 -15.13 -0.68 1.04e-37 Lobe attachment (rater-scored or self-reported); CESC trans rs61931739 0.500 rs11053193 chr12:34438838 G/T cg26384229 chr12:38710491 ALG10B 0.69 10.44 0.54 1.39e-21 Morning vs. evening chronotype; CESC cis rs1552244 0.554 rs3732963 chr3:10048885 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -7.27 -0.41 4.1e-12 Alzheimer's disease; CESC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.8 0.39 6.78e-11 Bipolar disorder; CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg23978390 chr7:1156363 C7orf50 0.58 8.0 0.44 3.89e-14 Longevity;Endometriosis; CESC cis rs7246865 0.510 rs2305752 chr19:17186127 A/C cg16202187 chr19:17186497 HAUS8;MYO9B 0.5 6.39 0.37 7.49e-10 Reticulocyte fraction of red cells; CESC cis rs4727027 0.704 rs12704073 chr7:148905067 G/A cg23583168 chr7:148888333 NA -0.93 -16.64 -0.71 4.58e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.43 0.37 5.96e-10 Bipolar disorder; CESC cis rs1256061 0.624 rs944047 chr14:64700292 C/T cg23250157 chr14:64679961 SYNE2 0.52 7.38 0.41 2.1e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2247341 1.000 rs8051 chr4:1694809 C/T cg07465881 chr4:1713556 SLBP 0.52 6.52 0.37 3.47e-10 Hip circumference adjusted for BMI;Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09859416 chr12:34262100 NA -0.54 -6.1 -0.35 3.69e-9 Gut microbiome composition (summer); CESC cis rs9303401 0.573 rs34097494 chr17:57171917 C/T cg25039879 chr17:56429692 SUPT4H1 0.5 5.29 0.31 2.58e-7 Cognitive test performance; CESC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.38 -6.82 -0.39 6.12e-11 Bipolar disorder; CESC cis rs4808199 0.948 rs757000 chr19:19448301 A/G cg03709012 chr19:19516395 GATAD2A 1.14 12.23 0.6 1.49e-27 Nonalcoholic fatty liver disease; CESC trans rs1814175 0.566 rs1811673 chr11:49602134 A/G cg03929089 chr4:120376271 NA -0.75 -8.56 -0.47 9.04e-16 Height; CESC cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg03433033 chr1:76189801 ACADM 0.74 10.37 0.54 2.21e-21 Blood metabolite levels;Acylcarnitine levels; CESC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg18490616 chr2:88469792 THNSL2 -0.53 -7.93 -0.44 6.03e-14 Response to metformin (IC50); CESC cis rs3820928 0.874 rs4675131 chr2:227836742 T/G cg05526886 chr2:227700861 RHBDD1 -0.44 -5.53 -0.32 7.61e-8 Pulmonary function; CESC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg22143856 chr6:28129313 ZNF389 0.52 6.71 0.38 1.21e-10 Depression; CESC cis rs11638352 1.000 rs7166715 chr15:44417606 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.61 -5.62 -0.33 4.75e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs651907 0.557 rs11924013 chr3:101366698 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 6.89 0.39 4.12e-11 Colorectal cancer; CESC cis rs950776 0.518 rs12910978 chr15:78810017 A/G cg24631222 chr15:78858424 CHRNA5 -0.4 -5.09 -0.3 6.79e-7 Sudden cardiac arrest; CESC cis rs798554 0.616 rs1636251 chr7:2884720 T/C cg13628971 chr7:2884303 GNA12 0.46 6.23 0.36 1.87e-9 Height; CESC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.7 -0.38 1.24e-10 Total body bone mineral density; CESC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg14926445 chr8:58193284 C8orf71 -0.54 -5.18 -0.3 4.5e-7 Developmental language disorder (linguistic errors); CESC cis rs796364 0.756 rs2949006 chr2:200715388 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.83 7.86 0.43 9.64e-14 Schizophrenia; CESC cis rs6500395 0.962 rs11648101 chr16:48714178 C/T cg04672837 chr16:48644449 N4BP1 0.46 5.27 0.31 2.77e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs57709857 0.957 rs11989357 chr8:38194561 C/G cg01506891 chr8:38243824 LETM2 0.45 5.05 0.3 8.39e-7 Autism spectrum disorder or schizophrenia; CESC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg27170947 chr2:26402098 FAM59B 0.87 9.89 0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs2014572 0.901 rs35658377 chr19:57755627 T/G cg24459738 chr19:57751996 ZNF805 -0.54 -7.76 -0.43 1.84e-13 Hyperactive-impulsive symptoms; CESC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg00684032 chr4:1343700 KIAA1530 0.36 5.56 0.32 6.59e-8 Longevity; CESC cis rs10883723 0.775 rs7917158 chr10:104246471 C/A cg22532475 chr10:104410764 TRIM8 -0.33 -5.68 -0.33 3.59e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs9815354 0.597 rs73073281 chr3:42026366 C/T cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg08822215 chr16:89438651 ANKRD11 0.48 7.64 0.42 4e-13 Multiple myeloma (IgH translocation); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07155664 chr5:149829590 RPS14 -0.44 -6.13 -0.35 3.16e-9 Asthma; CESC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg04944784 chr2:26401820 FAM59B -0.66 -7.62 -0.42 4.62e-13 Gut microbiome composition (summer); CESC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg05457628 chr5:178986728 RUFY1 -0.57 -8.75 -0.47 2.61e-16 Lung cancer; CESC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.83 0.34 1.59e-8 Tonsillectomy; CESC cis rs6121246 0.909 rs6058463 chr20:30385192 C/T cg13852791 chr20:30311386 BCL2L1 0.81 8.61 0.47 6.48e-16 Mean corpuscular hemoglobin; CESC cis rs12545109 0.800 rs1467123 chr8:57418870 C/T cg09654669 chr8:57350985 NA -0.45 -6.27 -0.36 1.47e-9 Obesity-related traits; CESC cis rs1005277 0.522 rs1208681 chr10:38092975 C/T cg00409905 chr10:38381863 ZNF37A -0.5 -7.04 -0.4 1.61e-11 Extrinsic epigenetic age acceleration; CESC cis rs796364 0.806 rs74706215 chr2:200941367 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.77 -6.8 -0.39 6.95e-11 Schizophrenia; CESC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg13012494 chr21:47604986 C21orf56 -0.51 -7.0 -0.39 2.12e-11 Testicular germ cell tumor; CESC cis rs712039 0.652 rs17137970 chr17:35771826 C/T cg16670864 chr17:35848621 DUSP14 0.42 5.27 0.31 2.88e-7 Tuberculosis; CESC cis rs4906332 0.966 rs7401563 chr14:103964425 G/A cg09975044 chr14:104007538 NA 0.47 6.34 0.36 1.01e-9 Coronary artery disease; CESC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg10691866 chr7:65817282 TPST1 0.31 5.24 0.31 3.34e-7 Aortic root size; CESC cis rs5758659 0.652 rs5758553 chr22:42431429 G/A cg15557168 chr22:42548783 NA -0.48 -7.52 -0.42 8.44e-13 Cognitive function; CESC cis rs2777491 0.957 rs6493002 chr15:41709195 C/G cg02330683 chr15:41787940 ITPKA 0.48 7.11 0.4 1.07e-11 Ulcerative colitis; CESC cis rs12681288 0.578 rs10503154 chr8:969343 C/G cg15309053 chr8:964076 NA 0.54 8.84 0.48 1.38e-16 Schizophrenia; CESC cis rs965469 0.696 rs6037570 chr20:3334292 C/A cg17110299 chr20:3385021 C20orf194 0.43 5.6 0.33 5.48e-8 IFN-related cytopenia; CESC cis rs11871801 0.915 rs647397 chr17:40679398 G/A cg21433558 chr17:40837037 CNTNAP1 0.45 5.18 0.3 4.32e-7 Crohn's disease; CESC cis rs17253792 0.822 rs8009239 chr14:56062490 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.62 0.33 4.81e-8 Putamen volume; CESC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg20151795 chr6:28129481 ZNF389 0.36 5.18 0.3 4.31e-7 Cardiac Troponin-T levels; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09800235 chr12:133250183 POLE -0.47 -6.22 -0.36 1.95e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs34375054 0.624 rs4073534 chr12:125671800 C/T cg25124228 chr12:125621409 AACS -0.46 -5.24 -0.31 3.23e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs3750965 0.919 rs12280942 chr11:68859683 A/G cg01403660 chr11:68851641 TPCN2 -0.4 -5.69 -0.33 3.34e-8 Hair color; CESC cis rs2485892 0.553 rs4844954 chr1:210337043 A/G cg21951975 chr1:209979733 IRF6 0.45 5.7 0.33 3.24e-8 Manic episodes in bipolar disorder; CESC cis rs919433 0.783 rs2565158 chr2:198236103 T/A cg03934865 chr2:198174659 NA 0.43 6.21 0.36 2.03e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs6951245 0.580 rs78894484 chr7:1138721 T/G cg13565492 chr6:43139072 SRF -0.75 -8.94 -0.48 7.05e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg16590910 chr6:42928470 GNMT 0.44 6.42 0.37 6.31e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg17372223 chr3:52568218 NT5DC2 0.45 7.44 0.42 1.39e-12 Cognitive function; CESC cis rs854765 0.603 rs4506967 chr17:17990474 A/C cg16928487 chr17:17741425 SREBF1 -0.53 -8.76 -0.47 2.34e-16 Total body bone mineral density; CESC cis rs2952156 0.920 rs12940986 chr17:37836581 A/G cg00129232 chr17:37814104 STARD3 0.76 11.31 0.57 1.84e-24 Asthma; CESC cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.45 0.46 2e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12477438 0.748 rs10200974 chr2:99675227 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.66 -0.47 4.63e-16 Chronic sinus infection; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05832119 chr17:41132480 AARSD1;RUNDC1 -0.53 -6.53 -0.37 3.38e-10 Ulcerative colitis; CESC trans rs9325144 0.671 rs12818797 chr12:39019409 A/G cg23762105 chr12:34175262 ALG10 0.47 6.27 0.36 1.44e-9 Morning vs. evening chronotype; CESC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.4 0.32 1.45e-7 Major depressive disorder; CESC cis rs11718455 0.960 rs35711021 chr3:44004791 G/A cg08738300 chr3:44038990 NA 0.46 6.12 0.35 3.34e-9 Coronary artery disease; CESC cis rs6540556 0.723 rs12120361 chr1:209913473 A/C cg05527609 chr1:210001259 C1orf107 -0.62 -7.33 -0.41 2.73e-12 Red blood cell count; CESC cis rs2012796 0.785 rs61986599 chr14:81860917 G/A cg02996355 chr14:81879375 NA 0.66 8.31 0.45 4.93e-15 Night sleep phenotypes; CESC cis rs3960554 0.740 rs10216079 chr7:75690988 A/C cg17325771 chr7:75508891 RHBDD2 -0.35 -5.23 -0.31 3.42e-7 Eotaxin levels; CESC cis rs11864453 0.713 rs12708927 chr16:72126165 C/T cg16558253 chr16:72132732 DHX38 -0.56 -8.7 -0.47 3.62e-16 Fibrinogen levels; CESC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg19163074 chr7:65112434 INTS4L2 0.44 5.5 0.32 9.04e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07474652 chr3:47823067 SMARCC1 0.53 6.04 0.35 5.16e-9 Gut microbiome composition (summer); CESC cis rs7659604 0.605 rs2071486 chr4:122740162 C/T cg19748678 chr4:122722346 EXOSC9 0.72 9.27 0.49 6.93e-18 Type 2 diabetes; CESC cis rs9902453 0.933 rs7225462 chr17:28321226 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 8.75 0.47 2.61e-16 Coffee consumption (cups per day); CESC cis rs7927771 0.542 rs3886262 chr11:47817010 T/G cg20307385 chr11:47447363 PSMC3 0.62 8.62 0.47 6.37e-16 Subjective well-being; CESC cis rs4481887 0.927 rs4244184 chr1:248486895 G/T cg00666640 chr1:248458726 OR2T12 0.36 6.17 0.35 2.56e-9 Common traits (Other); CESC cis rs17001868 0.614 rs5995849 chr22:40777072 C/G cg07138101 chr22:40742427 ADSL -0.5 -5.18 -0.3 4.5e-7 Mammographic density (dense area); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10507156 chr12:121903328 KDM2B -0.48 -6.43 -0.37 5.81e-10 Systemic lupus erythematosus; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg01087869 chr16:31501642 C16orf58;SLC5A2 0.43 6.48 0.37 4.57e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs709400 0.628 rs1989565 chr14:103862193 G/A cg18329187 chr14:103989711 CKB -0.29 -5.11 -0.3 6.3e-7 Body mass index; CESC cis rs4820294 1.000 rs41280035 chr22:38054038 A/G cg21798802 chr22:38057573 PDXP 0.43 7.15 0.4 8.32e-12 Fat distribution (HIV); CESC cis rs3204270 0.639 rs62077183 chr17:79658940 C/A cg26965718 chr17:79658957 HGS -0.76 -5.67 -0.33 3.81e-8 Dental caries; CESC cis rs6499255 0.904 rs12595927 chr16:69716338 C/G cg15192750 chr16:69999425 NA 0.48 5.48 0.32 9.78e-8 IgE levels; CESC cis rs77741769 0.571 rs989987 chr12:121274062 C/T cg02419362 chr12:121203948 SPPL3 0.34 5.5 0.32 8.97e-8 Mean corpuscular volume; CESC cis rs3857536 0.813 rs9360190 chr6:66942302 T/C cg07460842 chr6:66804631 NA -0.41 -5.28 -0.31 2.71e-7 Blood trace element (Cu levels); CESC cis rs2243480 1.000 rs73142166 chr7:65375832 A/G cg12463550 chr7:65579703 CRCP 0.72 5.53 0.32 7.65e-8 Diabetic kidney disease; CESC cis rs71277158 0.688 rs12492606 chr3:169808354 A/G cg04067573 chr3:169899625 PHC3 -0.62 -6.24 -0.36 1.71e-9 Prostate cancer; CESC cis rs6496667 0.779 rs7163560 chr15:91038620 A/T cg13834112 chr15:90361639 NA 0.4 5.37 0.31 1.71e-7 Rheumatoid arthritis; CESC cis rs2243480 1.000 rs6974723 chr7:65637939 C/T cg12463550 chr7:65579703 CRCP -0.73 -5.71 -0.33 3.1e-8 Diabetic kidney disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02836479 chr16:21964489 UQCRC2 -0.46 -6.21 -0.36 2.02e-9 Gut microbiota (bacterial taxa); CESC cis rs2832077 0.506 rs2832093 chr21:30164855 C/T cg08807101 chr21:30365312 RNF160 -0.46 -5.14 -0.3 5.46e-7 Cognitive test performance; CESC cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg11752832 chr7:134001865 SLC35B4 0.54 7.1 0.4 1.13e-11 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13284070 chr3:128483832 RAB7A 0.48 6.07 0.35 4.37e-9 Fibrinogen levels; CESC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg13393036 chr8:95962371 TP53INP1 0.46 9.73 0.51 2.54e-19 Type 2 diabetes; CESC trans rs1814175 0.527 rs10769595 chr11:49638212 A/G cg03929089 chr4:120376271 NA -0.71 -8.38 -0.46 3.16e-15 Height; CESC cis rs4635969 1.000 rs4635969 chr5:1308552 C/T cg06550200 chr5:1325588 CLPTM1L -0.71 -7.61 -0.42 4.78e-13 Testicular germ cell tumor;Testicular germ cell cancer; CESC cis rs10504229 0.679 rs12675340 chr8:58035501 T/A cg22535103 chr8:58192502 C8orf71 -0.61 -6.84 -0.39 5.31e-11 Developmental language disorder (linguistic errors); CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg04025307 chr7:1156635 C7orf50 0.48 6.68 0.38 1.4e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7726839 0.561 rs6555357 chr5:560923 A/G cg16447950 chr5:562315 NA -0.62 -7.2 -0.4 6.29e-12 Obesity-related traits; CESC cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg21918786 chr6:109611834 NA -0.39 -6.04 -0.35 5.1e-9 Reticulocyte fraction of red cells; CESC cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg06627628 chr2:24431161 ITSN2 -0.63 -5.96 -0.34 8.13e-9 Lymphocyte counts; CESC cis rs782590 0.967 rs1975487 chr2:55809054 A/G cg18811423 chr2:55921094 PNPT1 0.8 12.7 0.62 3.46e-29 Metabolic syndrome; CESC cis rs1044826 0.619 rs7375091 chr3:139090389 T/A cg00490450 chr3:139108681 COPB2 -0.42 -5.15 -0.3 5.21e-7 Obesity-related traits; CESC cis rs11098499 0.526 rs10026625 chr4:120280136 T/C cg09307838 chr4:120376055 NA 0.66 9.0 0.48 4.57e-17 Corneal astigmatism; CESC cis rs2455799 0.613 rs13071730 chr3:15891035 C/T cg16303742 chr3:15540471 COLQ -0.35 -5.3 -0.31 2.4e-7 Mean platelet volume; CESC cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg00409905 chr10:38381863 ZNF37A -0.47 -6.31 -0.36 1.16e-9 Extrinsic epigenetic age acceleration; CESC cis rs6723226 0.764 rs176403 chr2:32637864 C/A cg02381751 chr2:32503542 YIPF4 -0.84 -12.01 -0.59 7.79e-27 Intelligence (multi-trait analysis); CESC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg20887711 chr4:1340912 KIAA1530 0.46 6.13 0.35 3.19e-9 Longevity; CESC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.4 7.4 0.41 1.83e-12 Electroencephalogram traits; CESC cis rs68170813 0.559 rs6947675 chr7:106817184 T/C cg02696742 chr7:106810147 HBP1 -0.55 -5.33 -0.31 2.1e-7 Coronary artery disease; CESC cis rs5758659 0.714 rs7245 chr22:42481849 G/A cg15557168 chr22:42548783 NA 0.49 7.53 0.42 7.97e-13 Cognitive function; CESC cis rs12200560 0.505 rs9400166 chr6:97077101 G/A cg06623918 chr6:96969491 KIAA0776 0.5 6.42 0.37 6.42e-10 Coronary heart disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10139015 chr11:47448256 PSMC3 -0.72 -8.85 -0.48 1.24e-16 Gut microbiome composition (summer); CESC trans rs17685 0.753 rs1637037 chr7:75692927 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 12.37 0.61 4.74e-28 Coffee consumption;Coffee consumption (cups per day); CESC trans rs5758511 0.773 rs12167978 chr22:42346475 G/A cg15080870 chr19:47770746 CCDC9 0.49 6.1 0.35 3.78e-9 Birth weight; CESC cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg05347473 chr6:146136440 FBXO30 0.55 7.06 0.4 1.45e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1801251 1.000 rs56777991 chr2:233635388 A/C cg25237894 chr2:233734115 C2orf82 0.44 7.67 0.43 3.27e-13 Coronary artery disease; CESC cis rs5769765 0.542 rs1033666 chr22:50252783 T/C cg02269571 chr22:50332266 NA 0.46 5.45 0.32 1.16e-7 Schizophrenia; CESC cis rs4704187 0.649 rs1422701 chr5:74510517 T/G cg03227963 chr5:74354835 NA 0.28 5.04 0.3 8.66e-7 Response to amphetamines; CESC cis rs7914558 0.966 rs10883805 chr10:104708251 T/C cg15744005 chr10:104629667 AS3MT -0.35 -5.49 -0.32 9.41e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2637266 1.000 rs10824429 chr10:78346196 G/T cg18941641 chr10:78392320 NA 0.41 7.74 0.43 2.04e-13 Pulmonary function; CESC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg00612595 chr21:47717864 NA 0.42 5.69 0.33 3.43e-8 Testicular germ cell tumor; CESC cis rs9796 0.689 rs9888710 chr15:41446153 G/C cg12426344 chr15:41135900 SPINT1 -0.25 -5.48 -0.32 1e-7 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11038604 chr10:14996337 DCLRE1C 0.45 6.14 0.35 3.01e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6570726 0.905 rs442435 chr6:145815559 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.66 0.38 1.53e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4076764 0.515 rs4657268 chr1:163376507 A/T cg24596788 chr1:163392923 NA -0.34 -5.31 -0.31 2.31e-7 Motion sickness; CESC cis rs4148883 0.675 rs34511427 chr4:100105405 G/T cg12011299 chr4:100065546 ADH4 0.66 9.68 0.51 3.46e-19 Alcohol dependence; CESC cis rs11122272 0.735 rs2250734 chr1:231485958 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -7.43 -0.42 1.53e-12 Hemoglobin concentration; CESC trans rs7943203 1.000 rs4753842 chr11:108311606 G/C cg24643211 chr18:11851603 GNAL;CHMP1B -0.48 -6.05 -0.35 5.01e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg22638593 chr5:131593259 PDLIM4 -0.39 -5.09 -0.3 6.81e-7 Acylcarnitine levels; CESC cis rs9291683 0.655 rs35750364 chr4:10049049 T/C cg00071950 chr4:10020882 SLC2A9 0.85 14.85 0.67 1.04e-36 Bone mineral density; CESC cis rs2404602 0.647 rs920712 chr15:77033934 G/A cg23625390 chr15:77176239 SCAPER -0.47 -6.56 -0.37 2.75e-10 Blood metabolite levels; CESC cis rs17401966 1.000 rs17401966 chr1:10385471 C/T cg15208524 chr1:10270712 KIF1B -0.48 -6.19 -0.36 2.25e-9 Hepatocellular carcinoma; CESC cis rs9287719 0.837 rs4331474 chr2:10755583 G/A cg02196655 chr2:10830764 NOL10 -0.36 -5.43 -0.32 1.26e-7 Prostate cancer; CESC cis rs644799 1.000 rs500054 chr11:95593806 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 5.86 0.34 1.39e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11997175 0.646 rs67480501 chr8:33736315 C/T ch.8.33884649F chr8:33765107 NA 0.56 7.08 0.4 1.33e-11 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21892522 chr3:10052995 LOC401052 -0.45 -6.56 -0.37 2.79e-10 Fibrinogen levels; CESC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg18490616 chr2:88469792 THNSL2 0.56 5.38 0.31 1.64e-7 Plasma clusterin levels; CESC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs8133932 0.654 rs413517 chr21:47347545 C/G cg14185626 chr21:47401492 COL6A1 -0.48 -5.33 -0.31 2.07e-7 Schizophrenia; CESC cis rs8072100 0.817 rs9905581 chr17:45547185 C/T cg25173405 chr17:45401733 C17orf57 -0.47 -6.16 -0.35 2.72e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs3857536 0.813 rs1891599 chr6:66941699 A/G cg07460842 chr6:66804631 NA -0.41 -5.28 -0.31 2.71e-7 Blood trace element (Cu levels); CESC cis rs2297440 0.506 rs2236504 chr20:62224762 C/T cg06363034 chr20:62225388 GMEB2 -0.52 -6.68 -0.38 1.42e-10 Glioma;Non-glioblastoma glioma;Glioblastoma; CESC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg17372223 chr3:52568218 NT5DC2 0.43 6.43 0.37 5.84e-10 Bipolar disorder; CESC cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg10556349 chr10:835070 NA 0.57 5.48 0.32 9.87e-8 Eosinophil percentage of granulocytes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg25151688 chr15:66585534 DIS3L -0.44 -6.2 -0.36 2.21e-9 Asthma; CESC cis rs763014 0.931 rs3752568 chr16:628302 A/G cg07343612 chr16:622815 PIGQ -0.58 -8.47 -0.46 1.72e-15 Height; CESC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.9 14.01 0.65 9.7e-34 Prudent dietary pattern; CESC cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1218582 0.682 rs12046459 chr1:154912017 A/C cg24250549 chr1:154909240 PMVK 0.71 10.28 0.53 4.54e-21 Prostate cancer; CESC cis rs12136530 0.774 rs880361 chr1:19773421 A/T cg01832549 chr1:19774989 CAPZB -0.47 -6.5 -0.37 3.88e-10 Lead levels in blood; CESC cis rs2635047 0.811 rs12958943 chr18:44786818 T/C cg24371990 chr18:44770781 NA 0.41 6.49 0.37 4.2e-10 Educational attainment; CESC trans rs1814175 0.645 rs10839456 chr11:49964093 C/T cg03929089 chr4:120376271 NA -0.89 -14.87 -0.67 8.52e-37 Height; CESC cis rs12950390 0.853 rs56137679 chr17:45862112 C/G cg00777063 chr17:45855553 NA -0.38 -5.68 -0.33 3.49e-8 IgG glycosylation; CESC cis rs11690935 0.885 rs6752812 chr2:172851502 C/A cg13550731 chr2:172543902 DYNC1I2 -0.83 -12.24 -0.6 1.31e-27 Schizophrenia; CESC cis rs2070488 0.699 rs13064938 chr3:38440237 T/C cg24069376 chr3:38537580 EXOG 0.34 5.67 0.33 3.74e-8 Electrocardiographic conduction measures; CESC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg13206674 chr6:150067644 NUP43 0.39 5.58 0.32 5.93e-8 Lung cancer; CESC cis rs17253792 0.822 rs76192881 chr14:56034654 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.83 5.5 0.32 8.98e-8 Putamen volume; CESC cis rs116095464 0.558 rs6882584 chr5:223411 A/C cg10591111 chr5:226296 SDHA -0.51 -6.35 -0.36 9.22e-10 Breast cancer; CESC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg17143192 chr8:8559678 CLDN23 -0.44 -5.38 -0.31 1.62e-7 Mood instability; CESC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg09177884 chr7:1199841 ZFAND2A -0.44 -5.68 -0.33 3.56e-8 Longevity;Endometriosis; CESC cis rs4481887 0.893 rs9651175 chr1:248446888 G/T cg00666640 chr1:248458726 OR2T12 0.38 6.48 0.37 4.49e-10 Common traits (Other); CESC cis rs2777491 0.507 rs11854081 chr15:41646398 C/T cg18705301 chr15:41695430 NDUFAF1 -1.05 -16.77 -0.72 1.61e-43 Ulcerative colitis; CESC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg14893161 chr1:205819251 PM20D1 0.79 12.37 0.61 4.66e-28 Menarche (age at onset); CESC cis rs7223966 0.691 rs9893518 chr17:62006997 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.45 5.2 0.3 4.02e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09590094 chr22:18506583 MICAL3 -0.49 -6.14 -0.35 2.94e-9 Ulcerative colitis; CESC cis rs11098499 0.954 rs11098525 chr4:120390152 G/A cg09307838 chr4:120376055 NA 0.95 13.98 0.65 1.2e-33 Corneal astigmatism; CESC cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC trans rs11098499 0.754 rs2036857 chr4:120249240 T/C cg25214090 chr10:38739885 LOC399744 0.62 8.64 0.47 5.24e-16 Corneal astigmatism; CESC cis rs10883723 0.810 rs2281879 chr10:104268877 C/G ch.10.2196322F chr10:104248062 ACTR1A 0.44 5.42 0.32 1.32e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs11122272 0.735 rs2808596 chr1:231530723 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -7.16 -0.4 8.14e-12 Hemoglobin concentration; CESC cis rs6545883 0.899 rs1562309 chr2:61770126 C/A cg15711740 chr2:61764176 XPO1 -0.43 -5.29 -0.31 2.56e-7 Tuberculosis; CESC cis rs7542091 0.704 rs1883331 chr1:210043483 A/G cg25204440 chr1:209979598 IRF6 0.37 5.1 0.3 6.55e-7 Monobrow; CESC cis rs6582630 0.502 rs12815350 chr12:38439921 A/T cg26384229 chr12:38710491 ALG10B 0.69 10.28 0.53 4.42e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs10791097 0.690 rs12284540 chr11:130729772 T/C cg09137382 chr11:130731461 NA 0.39 5.69 0.33 3.36e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15043642 chr5:141061863 ARAP3 0.6 6.89 0.39 4.03e-11 Gut microbiome composition (summer); CESC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg05564831 chr3:52568323 NT5DC2 0.47 7.46 0.42 1.24e-12 Electroencephalogram traits; CESC cis rs6982240 0.514 rs1865247 chr8:142274654 A/T cg27411547 chr8:142287226 NA -0.52 -7.28 -0.41 3.82e-12 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09326880 chr3:43147587 C3orf39 -0.43 -6.4 -0.37 7.01e-10 Fibrinogen levels; CESC cis rs2380220 0.576 rs7751219 chr6:96018915 G/A cg15832292 chr6:96025679 MANEA 0.74 7.75 0.43 1.95e-13 Behavioural disinhibition (generation interaction); CESC cis rs7589342 0.831 rs11124062 chr2:106455967 G/A cg16077055 chr2:106428750 NCK2 0.49 7.04 0.4 1.7e-11 Addiction; CESC cis rs2777491 0.574 rs316611 chr15:41751678 A/G cg18705301 chr15:41695430 NDUFAF1 0.97 15.29 0.68 2.91e-38 Ulcerative colitis; CESC cis rs1008375 0.966 rs6449325 chr4:17699509 C/T cg16339924 chr4:17578868 LAP3 -0.49 -5.76 -0.33 2.27e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs13242816 1.000 rs2402078 chr7:116128648 A/C cg04696780 chr7:116139425 CAV2 -0.61 -5.56 -0.32 6.58e-8 P wave duration; CESC cis rs4237845 0.804 rs11172372 chr12:58286273 T/C cg00677455 chr12:58241039 CTDSP2 0.43 5.73 0.33 2.77e-8 Intelligence (multi-trait analysis); CESC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg19163074 chr7:65112434 INTS4L2 0.41 5.12 0.3 5.9e-7 Aortic root size; CESC trans rs7726839 0.574 rs72705014 chr5:619815 C/G cg25482853 chr8:67687455 SGK3 1.02 9.93 0.52 5.72e-20 Obesity-related traits; CESC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg18404041 chr3:52824283 ITIH1 -0.41 -6.78 -0.38 7.75e-11 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08886546 chr19:19051335 HOMER3 -0.51 -6.88 -0.39 4.2e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.11e-8 Alzheimer's disease; CESC cis rs4921915 0.526 rs13277738 chr8:18241507 C/T cg18736775 chr8:18248649 NAT2 -0.51 -5.13 -0.3 5.48e-7 Iron status biomarkers (transferrin levels); CESC cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg24733560 chr20:60626293 TAF4 0.45 6.7 0.38 1.24e-10 Body mass index; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24342864 chr17:17184608 COPS3 0.43 6.36 0.36 8.57e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4561483 0.771 rs12924398 chr16:11972948 T/A cg08843971 chr16:11963173 GSPT1 -0.4 -5.61 -0.33 5.1e-8 Testicular germ cell tumor; CESC cis rs644799 1.000 rs693597 chr11:95589629 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.93 13.27 0.63 3.57e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1707322 0.752 rs28507722 chr1:46206540 A/G cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg10578991 chr7:12443926 VWDE -0.51 -5.61 -0.33 5.17e-8 Coronary artery disease; CESC cis rs870825 0.616 rs28672716 chr4:185647345 G/A cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs7103648 0.966 rs1534576 chr11:47419663 A/C cg20307385 chr11:47447363 PSMC3 -0.97 -17.32 -0.73 1.76e-45 Diastolic blood pressure;Systolic blood pressure; CESC cis rs2066819 1.000 rs2643623 chr12:56689725 G/C cg26316697 chr12:56727976 PAN2 -0.69 -6.64 -0.38 1.74e-10 Psoriasis vulgaris; CESC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg13175981 chr1:150552382 MCL1 -0.4 -5.09 -0.3 6.96e-7 Tonsillectomy; CESC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg04317338 chr11:64019027 PLCB3 0.87 9.06 0.49 3.04e-17 Mean platelet volume; CESC cis rs12681288 0.676 rs34282191 chr8:991290 G/A cg15309053 chr8:964076 NA 0.39 6.49 0.37 4.2e-10 Schizophrenia; CESC cis rs2617583 0.967 rs2617594 chr5:1448288 A/G cg07151155 chr5:1473589 LPCAT1 -0.36 -5.5 -0.32 8.87e-8 Breast cancer; CESC cis rs9354308 0.933 rs2802062 chr6:66561973 C/G cg07460842 chr6:66804631 NA 0.66 7.52 0.42 8.27e-13 Metabolite levels; CESC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg27535305 chr1:53392650 SCP2 0.35 6.09 0.35 4.04e-9 Monocyte count; CESC cis rs6570726 0.846 rs9399559 chr6:145945778 C/T cg23711669 chr6:146136114 FBXO30 0.87 12.7 0.61 3.59e-29 Lobe attachment (rater-scored or self-reported); CESC trans rs35110281 0.681 rs162343 chr21:44957072 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 6.7 0.38 1.26e-10 Mean corpuscular volume; CESC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg12463550 chr7:65579703 CRCP 0.49 6.21 0.36 2.07e-9 Aortic root size; CESC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg04511125 chr2:88470314 THNSL2 -0.51 -7.42 -0.41 1.64e-12 Response to metformin (IC50); CESC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg12756686 chr19:29218302 NA 0.57 7.39 0.41 1.95e-12 Methadone dose in opioid dependence; CESC cis rs7503807 0.664 rs35524093 chr17:78574246 A/G cg09596252 chr17:78655493 RPTOR 0.39 5.26 0.31 2.96e-7 Obesity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04186169 chr6:139695202 CITED2 -0.54 -6.08 -0.35 4.09e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04473235 chr5:77080995 NA -0.67 -8.33 -0.46 4.49e-15 Gut microbiome composition (summer); CESC cis rs9457247 0.967 rs2149092 chr6:167372978 C/T cg07741184 chr6:167504864 NA -0.3 -5.39 -0.31 1.6e-7 Crohn's disease; CESC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg18876405 chr7:65276391 NA 0.52 6.97 0.39 2.54e-11 Aortic root size; CESC cis rs2408955 0.522 rs7139330 chr12:48483484 A/C cg04545296 chr12:48745243 ZNF641 -0.35 -6.13 -0.35 3.2e-9 Glycated hemoglobin levels; CESC cis rs2880765 0.566 rs11630381 chr15:86012503 A/G cg10818794 chr15:86012489 AKAP13 -0.36 -5.04 -0.3 8.8e-7 Coronary artery disease; CESC cis rs2249625 0.545 rs2496495 chr6:72882414 G/A cg18830697 chr6:72922368 RIMS1 -0.47 -6.88 -0.39 4.4e-11 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs2070677 1.000 rs2070677 chr10:135351174 A/T cg20169779 chr10:135381914 SYCE1 -0.67 -8.24 -0.45 8.23e-15 Gout; CESC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3106136 0.933 rs35718240 chr4:95164030 G/A cg11021082 chr4:95130006 SMARCAD1 -0.38 -5.52 -0.32 7.95e-8 Capecitabine sensitivity; CESC cis rs12458462 0.851 rs3859317 chr18:77443093 A/C cg11879182 chr18:77439856 CTDP1 0.86 13.41 0.64 1.19e-31 Monocyte count; CESC cis rs9815354 0.812 rs4299460 chr3:41952445 A/C cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.9e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7131987 0.903 rs1991114 chr12:29392082 G/T cg09582351 chr12:29534625 ERGIC2 -0.33 -5.25 -0.31 3.13e-7 QT interval; CESC cis rs6598955 0.724 rs12732295 chr1:26602251 C/T cg00852783 chr1:26633632 UBXN11 0.42 6.15 0.35 2.9e-9 Obesity-related traits; CESC cis rs6835098 1.000 rs10031414 chr4:174084953 A/C cg08422745 chr4:174089978 GALNT7 -0.84 -12.18 -0.6 2.12e-27 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.62 8.39 0.46 2.99e-15 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27646848 chr11:62389601 B3GAT3 0.68 8.27 0.45 6.64e-15 Gut microbiome composition (summer); CESC cis rs4660306 0.961 rs4660860 chr1:45946233 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.86e-13 Homocysteine levels; CESC cis rs7250872 0.619 rs2396359 chr19:1819125 T/C cg05970437 chr19:1864622 KLF16 0.5 5.84 0.34 1.52e-8 Bipolar disorder; CESC cis rs12410462 0.581 rs4329477 chr1:227552494 A/G cg04117972 chr1:227635322 NA -0.59 -5.59 -0.32 5.66e-8 Major depressive disorder; CESC cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg21395723 chr22:39101663 GTPBP1 0.43 5.29 0.31 2.55e-7 Menopause (age at onset); CESC cis rs2070488 0.965 rs2284820 chr3:38562579 C/T cg24069376 chr3:38537580 EXOG -0.45 -8.39 -0.46 2.9e-15 Electrocardiographic conduction measures; CESC cis rs7208859 0.673 rs36056619 chr17:29172284 T/C cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.86 14.63 0.67 6.08e-36 Menarche (age at onset); CESC cis rs861020 0.606 rs2184919 chr1:210000015 C/T cg05527609 chr1:210001259 C1orf107 -0.71 -9.64 -0.51 4.71e-19 Orofacial clefts; CESC cis rs9287719 0.904 rs55738250 chr2:10757132 G/A cg02196655 chr2:10830764 NOL10 -0.37 -5.67 -0.33 3.73e-8 Prostate cancer; CESC cis rs929354 0.772 rs10230895 chr7:157007038 T/C cg05182265 chr7:156933206 UBE3C -0.49 -7.25 -0.41 4.51e-12 Body mass index; CESC cis rs17253792 0.822 rs76055105 chr14:56069127 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg06456125 chr7:65229604 NA 0.39 5.05 0.3 8.06e-7 Aortic root size; CESC cis rs826838 0.678 rs11182781 chr12:38610178 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.88 0.39 4.41e-11 Heart rate; CESC cis rs796364 0.806 rs79053279 chr2:201057443 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.82 -6.91 -0.39 3.63e-11 Schizophrenia; CESC cis rs6904897 0.538 rs4639353 chr6:135224328 A/G cg24558204 chr6:135376177 HBS1L -0.52 -7.07 -0.4 1.4e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs62344088 1.000 rs6898413 chr5:173927 A/C cg22857025 chr5:266934 NA -1.18 -7.34 -0.41 2.66e-12 Asthma (childhood onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08092446 chr19:58987653 ZNF446 -0.47 -6.52 -0.37 3.51e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9462846 0.959 rs9471954 chr6:42880326 C/A cg02353165 chr6:42928485 GNMT 0.5 5.94 0.34 9.01e-9 Blood protein levels; CESC trans rs9329221 0.621 rs522483 chr8:9812969 C/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.14 -0.4 8.94e-12 Neuroticism; CESC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs1005277 0.691 rs2474558 chr10:38486141 A/C cg25427524 chr10:38739819 LOC399744 0.6 7.79 0.43 1.51e-13 Extrinsic epigenetic age acceleration; CESC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg23161317 chr6:28129485 ZNF389 0.46 6.19 0.36 2.32e-9 Parkinson's disease; CESC cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg05347473 chr6:146136440 FBXO30 0.69 9.29 0.5 5.7e-18 Lobe attachment (rater-scored or self-reported); CESC cis rs2228479 0.717 rs62052210 chr16:89980158 A/G cg04013166 chr16:89971882 TCF25 0.72 7.14 0.4 9.22e-12 Skin colour saturation; CESC trans rs1116547 0.602 rs6883441 chr5:112798855 G/A cg10115368 chr14:100435663 NA 0.5 6.1 0.35 3.68e-9 Cerebral amyloid angiopathy; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg21462697 chr17:80765655 TBCD 0.48 6.32 0.36 1.08e-9 Recombination measurement; CESC cis rs6088580 0.634 rs6142164 chr20:33006597 C/T cg08999081 chr20:33150536 PIGU -0.64 -11.19 -0.57 4.76e-24 Glomerular filtration rate (creatinine); CESC cis rs4481887 0.636 rs6672981 chr1:248407200 C/T cg00666640 chr1:248458726 OR2T12 0.34 5.21 0.3 3.86e-7 Common traits (Other); CESC trans rs13098911 0.540 rs13066062 chr3:46018344 G/A cg10236987 chr1:228114221 WNT9A 0.6 6.17 0.35 2.61e-9 Celiac disease; CESC cis rs2456568 0.778 rs7940973 chr11:93682045 C/G cg05188948 chr11:93754288 HEPHL1 -0.27 -5.36 -0.31 1.79e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs597539 0.690 rs7129960 chr11:68622456 A/G cg01988459 chr11:68622903 NA -0.41 -5.3 -0.31 2.45e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg08027265 chr7:2291960 NA -0.46 -7.0 -0.39 2.13e-11 Bipolar disorder and schizophrenia; CESC cis rs67478160 0.643 rs12880821 chr14:104276049 C/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -6.81 -0.39 6.53e-11 Schizophrenia; CESC cis rs763014 0.898 rs916416 chr16:632198 T/A cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg02951883 chr7:2050386 MAD1L1 -0.44 -5.69 -0.33 3.4e-8 Bipolar disorder and schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21184075 chr14:58766462 ARID4A -0.48 -7.04 -0.4 1.67e-11 Gut microbiota (bacterial taxa); CESC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.88e-10 Life satisfaction; CESC cis rs9611565 0.918 rs4820438 chr22:41767135 C/T cg06481639 chr22:41940642 POLR3H -0.62 -6.8 -0.39 7.07e-11 Vitiligo; CESC cis rs7044106 0.734 rs10491784 chr9:123432289 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.09 0.53 1.84e-20 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21808837 chr5:176778472 LMAN2 -0.63 -7.12 -0.4 9.88e-12 Gut microbiome composition (summer); CESC cis rs80282103 0.618 rs74120451 chr10:1126866 T/C cg08668510 chr10:1095578 IDI1 0.72 5.72 0.33 2.85e-8 Glomerular filtration rate (creatinine); CESC trans rs9929218 0.953 rs16260 chr16:68771034 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -10.07 -0.53 2.13e-20 Colorectal cancer; CESC cis rs4727027 0.933 rs62505074 chr7:148834780 C/T cg23158103 chr7:148848205 ZNF398 -0.4 -6.51 -0.37 3.67e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg14393609 chr7:65229607 NA -0.47 -6.31 -0.36 1.14e-9 Aortic root size; CESC cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg13628971 chr7:2884303 GNA12 0.41 5.41 0.32 1.39e-7 Height; CESC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg19717773 chr7:2847554 GNA12 0.56 7.98 0.44 4.43e-14 Height; CESC cis rs1707322 0.752 rs4586014 chr1:46150443 A/G cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg20151795 chr6:28129481 ZNF389 0.45 5.92 0.34 9.77e-9 Depression; CESC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.65 0.47 5.19e-16 Menopause (age at onset); CESC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg26839252 chr6:160211577 TCP1;MRPL18 -0.48 -5.99 -0.35 6.75e-9 Age-related macular degeneration (geographic atrophy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21251000 chr13:103452780 BIVM;KDELC1 0.54 6.15 0.35 2.89e-9 Gut microbiome composition (summer); CESC cis rs13385 0.769 rs4913074 chr5:139613567 T/C cg26211634 chr5:139558579 C5orf32 0.48 5.24 0.31 3.28e-7 Atrial fibrillation; CESC cis rs1580019 0.587 rs2392069 chr7:32547154 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.8 0.76 1.12e-50 Cognitive ability; CESC cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg20607287 chr7:12443886 VWDE -0.77 -9.04 -0.49 3.38e-17 Coronary artery disease; CESC cis rs10845606 0.781 rs7972866 chr12:12828320 C/T cg04607235 chr12:12878440 APOLD1 -0.56 -6.82 -0.39 6.27e-11 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.21e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7845219 0.544 rs9643351 chr8:95917290 C/T cg16049864 chr8:95962084 TP53INP1 -0.5 -7.29 -0.41 3.66e-12 Type 2 diabetes; CESC cis rs2952156 0.920 rs903502 chr17:37829604 C/T cg07936489 chr17:37558343 FBXL20 -0.59 -7.52 -0.42 8.39e-13 Asthma; CESC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.95e-10 Life satisfaction; CESC cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg18876405 chr7:65276391 NA -0.49 -5.61 -0.33 5.18e-8 Aortic root size; CESC cis rs4561483 0.583 rs11075032 chr16:12004450 C/T cg08843971 chr16:11963173 GSPT1 0.46 6.46 0.37 5.06e-10 Testicular germ cell tumor; CESC cis rs651907 0.557 rs12629954 chr3:101360623 C/A cg12386194 chr3:101231763 SENP7 0.43 5.41 0.32 1.4e-7 Colorectal cancer; CESC cis rs11760633 0.672 rs6460870 chr7:1843200 C/G cg23422044 chr7:1970798 MAD1L1 -0.48 -5.54 -0.32 7.14e-8 Coronary artery disease; CESC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg17971929 chr21:40555470 PSMG1 -0.6 -7.77 -0.43 1.68e-13 Menarche (age at onset); CESC cis rs11098499 0.739 rs951570 chr4:120150467 T/C cg09307838 chr4:120376055 NA -0.66 -8.15 -0.45 1.41e-14 Corneal astigmatism; CESC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.49 6.96 0.39 2.69e-11 Bipolar disorder; CESC cis rs72781680 0.784 rs72798406 chr2:24180144 T/C cg08917208 chr2:24149416 ATAD2B 0.69 6.74 0.38 1e-10 Lymphocyte counts; CESC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg12288994 chr5:1860383 NA 0.4 6.64 0.38 1.79e-10 Cardiovascular disease risk factors; CESC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg13206674 chr6:150067644 NUP43 0.43 6.18 0.35 2.39e-9 Lung cancer; CESC cis rs858239 0.932 rs1728313 chr7:23271031 A/C cg23682824 chr7:23144976 KLHL7 0.45 6.04 0.35 5.17e-9 Cerebrospinal fluid biomarker levels; CESC cis rs6063312 1.000 rs6095261 chr20:47346494 C/A cg18078177 chr20:47281410 PREX1 0.56 5.49 0.32 9.43e-8 Tonometry; CESC cis rs7914558 0.966 rs10786724 chr10:104668942 A/G cg08650961 chr10:104748594 CNNM2 0.32 5.09 0.3 6.7e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.82 0.34 1.74e-8 Colonoscopy-negative controls vs population controls; CESC trans rs3780486 0.718 rs7859454 chr9:33119583 T/A cg04842962 chr6:43655489 MRPS18A 0.72 8.84 0.48 1.35e-16 IgG glycosylation; CESC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg19622623 chr12:86230825 RASSF9 -0.44 -5.3 -0.31 2.38e-7 Major depressive disorder; CESC cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg03676636 chr4:99064102 C4orf37 0.35 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03436653 chr3:9932323 JAGN1 0.57 6.23 0.36 1.81e-9 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.52 0.37 3.52e-10 Prudent dietary pattern; CESC cis rs6120849 0.518 rs11696652 chr20:33637060 T/G cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs4595586 0.545 rs12823487 chr12:39391286 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs79349575 0.783 rs4793998 chr17:47019899 C/T cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs897984 0.609 rs1108431 chr16:31054607 C/T cg02466173 chr16:30829666 NA -0.44 -7.68 -0.43 3.08e-13 Dementia with Lewy bodies; CESC cis rs1580019 0.563 rs4723169 chr7:32567577 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.97 0.76 2.73e-51 Cognitive ability; CESC cis rs2806561 0.929 rs856508 chr1:23532995 A/C cg12483005 chr1:23474871 LUZP1 0.32 5.05 0.3 8.18e-7 Height; CESC cis rs10979 1.000 rs9386036 chr6:143890709 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs9814567 0.762 rs13071253 chr3:134316653 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.05 0.35 4.86e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20935933 chr6:143382018 AIG1 0.59 6.68 0.38 1.37e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19960880 chr10:97050830 PDLIM1 0.57 6.32 0.36 1.1e-9 Gut microbiome composition (summer); CESC cis rs72781680 0.678 rs11125293 chr2:24102423 A/G cg08917208 chr2:24149416 ATAD2B 0.6 6.02 0.35 5.77e-9 Lymphocyte counts; CESC cis rs1950626 0.833 rs12892225 chr14:101415413 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.77 9.9 0.52 7.01e-20 Pelvic organ prolapse (moderate/severe); CESC cis rs477692 1.000 rs569235 chr10:131411620 T/C cg05714579 chr10:131428358 MGMT 0.48 6.43 0.37 5.82e-10 Response to temozolomide; CESC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.66 0.55 2.52e-22 Platelet count; CESC cis rs4595586 0.545 rs1400284 chr12:39400419 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs6546537 0.868 rs62133967 chr2:69891708 G/C cg10773587 chr2:69614142 GFPT1 -0.59 -6.86 -0.39 4.74e-11 Serum thyroid-stimulating hormone levels; CESC cis rs4148883 0.737 rs13148577 chr4:100060836 G/A cg12011299 chr4:100065546 ADH4 0.71 10.56 0.54 5.49e-22 Alcohol dependence; CESC cis rs12042052 0.590 rs2357332 chr1:232948252 C/T cg00951395 chr1:232941775 KIAA1383 -0.54 -5.2 -0.3 4.08e-7 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs9399135 0.660 rs4267967 chr6:135272477 T/G cg24558204 chr6:135376177 HBS1L 0.59 8.24 0.45 7.91e-15 Red blood cell count; CESC cis rs926938 0.501 rs360686 chr1:115502524 C/T cg12756093 chr1:115239321 AMPD1 0.41 5.45 0.32 1.13e-7 Autism; CESC cis rs2073300 0.609 rs6132606 chr20:23367453 G/A cg16736954 chr20:23401023 NAPB 0.8 6.25 0.36 1.67e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6547741 1.000 rs1080060 chr2:27768808 T/A cg27432699 chr2:27873401 GPN1 0.49 6.86 0.39 4.85e-11 Oral cavity cancer; CESC cis rs9914988 0.832 rs9903248 chr17:27127439 G/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs3105593 0.965 rs62017197 chr15:50940491 G/A cg08437265 chr15:50716283 USP8 0.42 5.49 0.32 9.47e-8 QT interval; CESC cis rs11650494 0.710 rs11651666 chr17:47474571 C/T cg08112188 chr17:47440006 ZNF652 1.15 7.89 0.44 7.86e-14 Prostate cancer; CESC cis rs7474896 0.515 rs675628 chr10:38305331 C/G cg25427524 chr10:38739819 LOC399744 0.5 5.62 0.33 4.91e-8 Obesity (extreme); CESC cis rs11997175 0.626 rs6468189 chr8:33648189 C/A ch.8.33884649F chr8:33765107 NA 0.54 6.72 0.38 1.11e-10 Body mass index; CESC cis rs2072732 0.716 rs72856433 chr1:2954061 G/A cg15211996 chr1:2936768 ACTRT2 0.31 5.51 0.32 8.53e-8 Plateletcrit; CESC cis rs3820068 0.581 rs72645877 chr1:15928106 G/T cg16988262 chr1:15930761 NA 0.35 5.65 0.33 4.18e-8 Systolic blood pressure; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg05694744 chr17:8191820 RANGRF;SLC25A35 -0.46 -6.83 -0.39 5.67e-11 Vertical cup-disc ratio; CESC cis rs7584330 0.737 rs7568588 chr2:238364342 G/T cg14458575 chr2:238380390 NA 0.62 8.43 0.46 2.3e-15 Prostate cancer; CESC cis rs8017423 0.935 rs59179255 chr14:90691773 A/C cg14092571 chr14:90743983 NA -0.56 -8.25 -0.45 7.35e-15 Mortality in heart failure; CESC cis rs12477438 0.765 rs2309520 chr2:99570477 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.64 8.72 0.47 3.22e-16 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14005384 chr15:89877925 POLG 0.56 6.2 0.36 2.2e-9 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02756545 chr1:94884060 ABCD3 0.48 6.64 0.38 1.73e-10 Systemic lupus erythematosus; CESC cis rs7580658 0.724 rs6712446 chr2:127998399 G/T cg10021288 chr2:128175891 PROC -0.4 -6.37 -0.36 8.33e-10 Protein C levels; CESC cis rs12410462 1.000 rs12410243 chr1:227669474 A/G cg04117972 chr1:227635322 NA 0.66 6.61 0.38 2.13e-10 Major depressive disorder; CESC cis rs35110281 0.594 rs230641 chr21:44915441 T/C cg01579765 chr21:45077557 HSF2BP 0.43 7.19 0.4 6.53e-12 Mean corpuscular volume; CESC cis rs11864453 0.749 rs7192730 chr16:72124219 T/C cg01557791 chr16:72042693 DHODH -0.46 -5.92 -0.34 9.98e-9 Fibrinogen levels; CESC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg16405210 chr4:1374714 KIAA1530 -0.44 -5.86 -0.34 1.36e-8 Obesity-related traits; CESC cis rs2180341 0.960 rs7773484 chr6:127670779 T/C cg24812749 chr6:127587940 RNF146 1.05 15.07 0.68 1.77e-37 Breast cancer; CESC cis rs1005224 1.000 rs1158282 chr14:76172916 C/G cg25116370 chr14:76127843 TTLL5;C14orf1 -0.39 -5.3 -0.31 2.42e-7 Large artery stroke; CESC cis rs7084402 0.967 rs2170779 chr10:60277249 G/A cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg04553112 chr3:125709451 NA -0.54 -5.82 -0.34 1.71e-8 Blood pressure (smoking interaction); CESC trans rs1814175 0.645 rs7928714 chr11:49887622 G/A cg03929089 chr4:120376271 NA -0.88 -14.39 -0.66 4.31e-35 Height; CESC cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.89 0.34 1.15e-8 Tonsillectomy; CESC cis rs12541635 0.677 rs2880950 chr8:106983624 C/A cg10147462 chr8:107024639 NA 0.46 6.71 0.38 1.19e-10 Age of smoking initiation; CESC cis rs722599 0.715 rs8008785 chr14:75307600 G/A cg08847533 chr14:75593920 NEK9 -0.48 -6.1 -0.35 3.82e-9 IgG glycosylation; CESC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg19257562 chr1:2043853 PRKCZ 0.4 6.58 0.37 2.44e-10 Height; CESC cis rs7296418 0.630 rs11057238 chr12:123767971 C/A cg00376283 chr12:123451042 ABCB9 0.58 7.91 0.44 7.01e-14 Platelet count; CESC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg23172400 chr8:95962367 TP53INP1 -0.44 -9.11 -0.49 2.05e-17 Type 2 diabetes; CESC cis rs5769765 0.720 rs138820 chr22:50164078 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.48 -5.19 -0.3 4.12e-7 Schizophrenia; CESC cis rs56399783 0.901 rs56356906 chr7:2774383 G/A cg19731401 chr7:2775893 GNA12 0.69 6.13 0.35 3.19e-9 Childhood ear infection; CESC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.85 0.65 3.59e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs861020 1.000 rs680923 chr1:209986672 T/C cg05527609 chr1:210001259 C1orf107 1.07 13.45 0.64 8.92e-32 Orofacial clefts; CESC trans rs12599106 0.715 rs34006830 chr16:34878550 C/A cg21548813 chr6:291882 DUSP22 -0.75 -9.73 -0.51 2.48e-19 Menopause (age at onset); CESC cis rs1003719 0.715 rs2835659 chr21:38567902 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.14 -0.45 1.59e-14 Eye color traits; CESC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg03351412 chr1:154909251 PMVK 0.59 7.47 0.42 1.14e-12 Prostate cancer; CESC cis rs7100689 0.577 rs2282367 chr10:82040346 A/G cg00277334 chr10:82204260 NA -0.52 -6.78 -0.38 7.96e-11 Post bronchodilator FEV1; CESC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg13126279 chr21:47581558 C21orf56 0.52 7.14 0.4 8.98e-12 Testicular germ cell tumor; CESC cis rs9487051 0.646 rs55677234 chr6:109621974 G/A cg01475377 chr6:109611718 NA -0.39 -5.39 -0.31 1.55e-7 Reticulocyte fraction of red cells; CESC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg07936489 chr17:37558343 FBXL20 -0.81 -12.02 -0.59 7.28e-27 Glomerular filtration rate (creatinine); CESC cis rs7208859 0.623 rs59447372 chr17:29057585 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg15112475 chr7:1198522 ZFAND2A -0.36 -5.77 -0.33 2.2e-8 Longevity;Endometriosis; CESC cis rs34779708 0.733 rs12254018 chr10:35550641 T/A cg04310649 chr10:35416472 CREM -0.46 -5.22 -0.31 3.55e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs6540556 0.723 rs1000282 chr1:209894785 T/C cg05527609 chr1:210001259 C1orf107 -0.66 -7.34 -0.41 2.56e-12 Red blood cell count; CESC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.49 0.37 4.31e-10 Bipolar disorder; CESC cis rs959260 0.610 rs9906825 chr17:73350580 C/T cg20590849 chr17:73267439 MIF4GD -0.56 -6.27 -0.36 1.49e-9 Systemic lupus erythematosus; CESC cis rs10875746 0.729 rs1990028 chr12:48408013 A/G cg24011408 chr12:48396354 COL2A1 -0.42 -5.12 -0.3 5.87e-7 Longevity (90 years and older); CESC cis rs599083 0.530 rs583545 chr11:68178635 T/C cg01657329 chr11:68192670 LRP5 0.44 5.23 0.31 3.39e-7 Bone mineral density (spine); CESC cis rs3741151 0.773 rs17244596 chr11:73179236 A/G cg17517138 chr11:73019481 ARHGEF17 0.95 6.99 0.39 2.29e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs1697139 0.583 rs11739727 chr5:66540940 G/A cg11553311 chr5:66541588 NA 0.39 5.46 0.32 1.12e-7 Breast cancer; CESC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.91 9.82 0.52 1.26e-19 Platelet count; CESC cis rs6582630 0.555 rs10785454 chr12:38476260 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.11 0.35 3.63e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs17376456 0.877 rs12153506 chr5:93360953 T/G cg25358565 chr5:93447407 FAM172A 1.1 10.93 0.56 3.31e-23 Diabetic retinopathy; CESC cis rs3749237 0.595 rs11720264 chr3:49580347 C/T cg06212747 chr3:49208901 KLHDC8B 0.47 6.32 0.36 1.13e-9 Resting heart rate; CESC trans rs459571 0.959 rs460888 chr9:136913123 C/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.66 -8.64 -0.47 5.55e-16 Platelet distribution width; CESC cis rs10751667 0.600 rs1128419 chr11:1010750 G/A cg01483505 chr11:975446 AP2A2 0.41 5.39 0.31 1.6e-7 Alzheimer's disease (late onset); CESC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.85 12.01 0.59 8.38e-27 Age-related macular degeneration (geographic atrophy); CESC cis rs761746 0.960 rs4535154 chr22:31896232 T/C cg25791279 chr22:32026902 PISD -0.51 -5.65 -0.33 4.17e-8 Intelligence; CESC cis rs1691799 0.867 rs961049 chr12:66762591 A/C cg16791601 chr12:66731901 HELB 0.56 8.79 0.47 1.98e-16 White blood cell count (basophil); CESC cis rs9457247 0.663 rs7749278 chr6:167435325 C/T cg07741184 chr6:167504864 NA -0.33 -5.79 -0.34 1.98e-8 Crohn's disease; CESC cis rs17376456 1.000 rs61132622 chr5:93539684 G/A cg21475434 chr5:93447410 FAM172A 0.86 7.69 0.43 2.82e-13 Diabetic retinopathy; CESC cis rs6089584 1.000 rs6089585 chr20:60564395 G/A cg13770153 chr20:60521292 NA -0.45 -5.9 -0.34 1.12e-8 Body mass index; CESC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg15664640 chr17:80829946 TBCD -0.63 -9.1 -0.49 2.3e-17 Breast cancer; CESC cis rs826838 0.934 rs10875647 chr12:38856995 G/A cg26384229 chr12:38710491 ALG10B 0.83 14.57 0.67 1.05e-35 Heart rate; CESC cis rs4925386 0.840 rs6143024 chr20:60914229 A/G cg22633769 chr20:60982531 CABLES2 0.55 5.63 0.33 4.64e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg05896524 chr21:47604654 C21orf56 -0.39 -5.11 -0.3 6.31e-7 Testicular germ cell tumor; CESC cis rs12477438 0.798 rs1453562 chr2:99615850 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs7605827 0.930 rs7578787 chr2:15655119 T/C cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.7e-10 Educational attainment (years of education); CESC cis rs6460942 0.597 rs17544637 chr7:12521871 T/C cg20607287 chr7:12443886 VWDE -0.63 -7.11 -0.4 1.1e-11 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24005340 chr5:168006702 PANK3 -0.42 -6.05 -0.35 4.82e-9 Gambling; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg21237687 chr17:6899380 ALOX12 -0.44 -7.01 -0.4 1.92e-11 Tonsillectomy; CESC cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg00106254 chr7:1943704 MAD1L1 -0.47 -5.82 -0.34 1.7e-8 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7107174 1.000 rs4945261 chr11:77990260 A/G cg02023728 chr11:77925099 USP35 -0.47 -6.48 -0.37 4.39e-10 Testicular germ cell tumor; CESC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg04248312 chr19:17393744 ANKLE1 -0.94 -15.37 -0.69 1.53e-38 Systemic lupus erythematosus; CESC cis rs2573652 1.000 rs2573625 chr15:100513158 A/G cg09918751 chr15:100517450 ADAMTS17 0.42 8.06 0.44 2.56e-14 Height; CESC cis rs11098499 0.909 rs28714195 chr4:120316950 A/T cg09307838 chr4:120376055 NA 0.92 12.46 0.61 2.41e-28 Corneal astigmatism; CESC cis rs9611565 0.559 rs4822048 chr22:41988225 C/T cg06481639 chr22:41940642 POLR3H -0.65 -6.38 -0.37 7.65e-10 Vitiligo; CESC cis rs7408868 0.563 rs11085949 chr19:15296917 G/T cg14696996 chr19:15285081 NOTCH3 0.98 9.89 0.52 7.82e-20 Pulse pressure; CESC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg27170947 chr2:26402098 FAM59B 0.87 10.16 0.53 1.05e-20 Gut microbiome composition (summer); CESC cis rs2066819 1.000 rs57870697 chr12:56752874 A/G cg26734620 chr12:56694298 CS 0.97 5.8 0.34 1.92e-8 Psoriasis vulgaris; CESC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -7.97 -0.44 4.6e-14 Developmental language disorder (linguistic errors); CESC cis rs4555082 0.834 rs2735819 chr14:105713449 C/T cg27165867 chr14:105738592 BRF1 -0.48 -5.16 -0.3 4.75e-7 Mean platelet volume;Platelet distribution width; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg05981015 chr17:27717136 TAOK1 -0.49 -6.62 -0.38 2.03e-10 Height; CESC cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg09997546 chr11:8931473 C11orf17;ST5 0.32 5.06 0.3 7.68e-7 Hemoglobin concentration; CESC cis rs116095464 1.000 rs62346511 chr5:208265 C/T cg22496380 chr5:211416 CCDC127 -0.92 -5.48 -0.32 9.95e-8 Breast cancer; CESC cis rs722599 0.715 rs2300598 chr14:75359229 T/C cg08847533 chr14:75593920 NEK9 -0.45 -5.34 -0.31 2.05e-7 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02075454 chr13:111364916 ING1 0.59 6.42 0.37 6.16e-10 Gut microbiome composition (summer); CESC cis rs62064224 0.658 rs62065460 chr17:30715007 A/G cg18200150 chr17:30822561 MYO1D 0.68 10.38 0.54 2.04e-21 Schizophrenia; CESC cis rs1144333 0.655 rs114383686 chr1:76325327 C/T cg10523679 chr1:76189770 ACADM 0.56 5.38 0.31 1.61e-7 Attention function in attention deficit hyperactive disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12506373 chr2:27440548 CAD 0.57 7.84 0.43 1.12e-13 Gut microbiota (bacterial taxa); CESC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs7726839 0.794 rs11739663 chr5:594083 A/G cg09021430 chr5:549028 NA -0.43 -6.09 -0.35 4.04e-9 Obesity-related traits; CESC cis rs7586879 0.639 rs6545776 chr2:25099357 A/C cg01884057 chr2:25150051 NA 0.38 7.3 0.41 3.44e-12 Body mass index; CESC cis rs5758659 0.652 rs133322 chr22:42405659 A/G cg15557168 chr22:42548783 NA -0.45 -6.68 -0.38 1.39e-10 Cognitive function; CESC cis rs12545109 0.671 rs35500854 chr8:57424303 G/A cg09654669 chr8:57350985 NA -0.56 -6.67 -0.38 1.46e-10 Obesity-related traits; CESC cis rs6121246 0.954 rs6089093 chr20:30421459 C/T cg13852791 chr20:30311386 BCL2L1 0.8 7.9 0.44 7.58e-14 Mean corpuscular hemoglobin; CESC cis rs8114671 0.836 rs6141526 chr20:33615255 G/T cg07148914 chr20:33460835 GGT7 -0.42 -5.48 -0.32 9.89e-8 Height; CESC cis rs1712517 0.526 rs113528138 chr10:105125451 C/A cg04362960 chr10:104952993 NT5C2 -0.46 -5.55 -0.32 6.86e-8 Migraine; CESC trans rs6499188 0.571 rs1645975 chr16:68564448 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs7917772 0.502 rs10748827 chr10:104368336 G/T ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.31 0.31 2.28e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs8180040 0.654 rs6773521 chr3:47234419 A/G cg27129171 chr3:47204927 SETD2 -0.66 -9.64 -0.51 4.74e-19 Colorectal cancer; CESC trans rs8073060 0.544 rs8071584 chr17:33999435 G/A cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs2880765 0.835 rs4280192 chr15:86043020 G/A cg19183879 chr15:85880815 NA -0.26 -5.33 -0.31 2.15e-7 Coronary artery disease; CESC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg17372223 chr3:52568218 NT5DC2 0.42 6.09 0.35 3.86e-9 Bipolar disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22187094 chr15:89878452 POLG 0.51 6.67 0.38 1.46e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9325144 0.560 rs11182952 chr12:38636278 C/A cg26384229 chr12:38710491 ALG10B -0.61 -8.58 -0.47 8.35e-16 Morning vs. evening chronotype; CESC cis rs10876993 0.890 rs1678539 chr12:58060359 A/G cg18357645 chr12:58087776 OS9 0.63 10.11 0.53 1.54e-20 Celiac disease or Rheumatoid arthritis; CESC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg06808227 chr14:105710500 BRF1 -0.64 -7.65 -0.43 3.72e-13 Mean platelet volume;Platelet distribution width; CESC cis rs8072100 0.790 rs11079783 chr17:45686016 C/T cg08085267 chr17:45401833 C17orf57 0.48 5.96 0.34 8.02e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg07701084 chr6:150067640 NUP43 0.43 5.8 0.34 1.9e-8 Lung cancer; CESC cis rs9611565 0.512 rs4512 chr22:42206084 G/C cg03806693 chr22:41940476 POLR3H -1.2 -13.55 -0.64 3.84e-32 Vitiligo; CESC cis rs9814567 1.000 rs6804770 chr3:134230234 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.76 -0.33 2.38e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4595586 0.545 rs12821810 chr12:39375858 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs13082711 0.554 rs9310843 chr3:27371260 A/G cg02860705 chr3:27208620 NA 0.51 6.55 0.37 2.99e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs2644899 0.750 rs2607414 chr19:41267129 C/T cg24958765 chr19:41283667 RAB4B 0.57 6.62 0.38 1.95e-10 Post bronchodilator FEV1/FVC ratio; CESC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg24250549 chr1:154909240 PMVK 0.74 11.1 0.56 9.2e-24 Prostate cancer; CESC trans rs1814175 0.817 rs7950856 chr11:49976394 C/T cg03929089 chr4:120376271 NA -0.93 -16.32 -0.71 6.51e-42 Height; CESC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.9 -13.83 -0.65 3.99e-33 Prudent dietary pattern; CESC cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg17366294 chr4:99064904 C4orf37 0.55 7.63 0.42 4.35e-13 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26350446 chr7:111202682 IMMP2L -0.53 -6.17 -0.35 2.52e-9 Gut microbiome composition (summer); CESC cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg11663144 chr21:46675770 NA -0.46 -7.09 -0.4 1.23e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1506636 1.000 rs684548 chr7:123397102 A/T cg03229431 chr7:123269106 ASB15 0.52 6.96 0.39 2.64e-11 Plateletcrit;Platelet count; CESC cis rs561341 0.709 rs11542477 chr17:30185892 A/G cg12193833 chr17:30244370 NA 0.63 6.08 0.35 4.25e-9 Hip circumference adjusted for BMI; CESC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg09699651 chr6:150184138 LRP11 0.39 5.04 0.3 8.83e-7 Lung cancer; CESC cis rs7542091 0.704 rs1108628 chr1:210041150 A/G cg21951975 chr1:209979733 IRF6 0.45 7.73 0.43 2.21e-13 Monobrow; CESC trans rs61931739 0.824 rs406753 chr12:34117408 A/G cg26384229 chr12:38710491 ALG10B 0.44 6.05 0.35 4.95e-9 Morning vs. evening chronotype; CESC cis rs12145833 0.596 rs12043646 chr1:243281992 G/A cg02356786 chr1:243265016 LOC731275 0.77 6.4 0.37 7.06e-10 Obesity (early onset extreme); CESC cis rs10791323 0.546 rs55801927 chr11:133713094 A/C cg14349672 chr11:133703707 NA -0.36 -5.06 -0.3 7.92e-7 Childhood ear infection; CESC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg11890956 chr21:40555474 PSMG1 -0.66 -9.09 -0.49 2.4e-17 Menarche (age at onset); CESC cis rs9467711 0.559 rs13208916 chr6:26601940 G/A cg12826209 chr6:26865740 GUSBL1 0.67 6.06 0.35 4.68e-9 Autism spectrum disorder or schizophrenia; CESC trans rs7987251 0.609 rs3736470 chr13:60617106 A/C cg27049993 chr17:65370839 NA 0.77 6.18 0.35 2.42e-9 Trans fatty acid levels; CESC cis rs7017914 0.934 rs1389202 chr8:71852285 C/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.33 -0.31 2.11e-7 Bone mineral density; CESC cis rs28830936 1.000 rs17678767 chr15:42096422 C/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.41 -5.59 -0.32 5.56e-8 Diastolic blood pressure; CESC cis rs921968 0.541 rs6717433 chr2:219375711 G/C cg02176678 chr2:219576539 TTLL4 -0.53 -9.3 -0.5 5.42e-18 Mean corpuscular hemoglobin concentration; CESC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.63 -0.33 4.68e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs12893668 0.703 rs8017993 chr14:104047734 A/G cg24130564 chr14:104152367 KLC1 -0.46 -5.76 -0.33 2.35e-8 Reticulocyte count; CESC cis rs11122272 0.735 rs2250749 chr1:231485763 C/G cg06096015 chr1:231504339 EGLN1 0.4 5.84 0.34 1.5e-8 Hemoglobin concentration; CESC cis rs7216064 0.817 rs12601921 chr17:65825354 C/T cg12091567 chr17:66097778 LOC651250 -0.87 -8.62 -0.47 6.33e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs77106637 0.929 rs1059000 chr11:72504972 G/C cg03713592 chr11:72463424 ARAP1 1.23 11.1 0.56 9.02e-24 Type 2 diabetes; CESC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg11644478 chr21:40555479 PSMG1 0.96 13.64 0.64 1.85e-32 Cognitive function; CESC cis rs6547741 1.000 rs4665381 chr2:27757150 A/C cg27432699 chr2:27873401 GPN1 0.49 6.78 0.38 7.74e-11 Oral cavity cancer; CESC cis rs936229 0.656 rs2290572 chr15:75130573 A/G cg14664628 chr15:75095509 CSK -0.56 -7.42 -0.41 1.58e-12 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs7296418 0.961 rs1790094 chr12:123586688 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.03 -0.3 8.87e-7 Platelet count; CESC cis rs7267979 1.000 rs447722 chr20:25443510 C/T cg08601574 chr20:25228251 PYGB 0.37 5.31 0.31 2.31e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.68 -0.58 1.06e-25 Alzheimer's disease; CESC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.64 0.38 1.78e-10 Bipolar disorder; CESC cis rs7267979 0.903 rs2474769 chr20:25248725 C/T cg08601574 chr20:25228251 PYGB 0.43 6.32 0.36 1.1e-9 Liver enzyme levels (alkaline phosphatase); CESC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg25566285 chr7:158114605 PTPRN2 0.49 8.13 0.45 1.64e-14 Calcium levels; CESC cis rs4342066 0.593 rs6792215 chr3:28276784 A/T cg15038811 chr3:28283857 CMC1 0.39 5.07 0.3 7.31e-7 Colonoscopy-negative controls vs population controls; CESC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg23172400 chr8:95962367 TP53INP1 -0.44 -8.97 -0.48 5.48e-17 Type 2 diabetes; CESC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg23034840 chr1:205782522 SLC41A1 0.66 7.97 0.44 4.68e-14 Menarche (age at onset); CESC cis rs8050907 0.744 rs13335503 chr16:4529028 T/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.89 6.26 0.36 1.51e-9 Obesity-related traits; CESC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg19622623 chr12:86230825 RASSF9 -0.46 -5.93 -0.34 9.45e-9 Major depressive disorder; CESC cis rs6582630 0.519 rs12366667 chr12:38332632 C/T cg26384229 chr12:38710491 ALG10B 0.73 10.9 0.56 4.29e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs2439831 0.867 rs16957632 chr15:43642897 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.37 0.54 2.22e-21 Lung cancer in ever smokers; CESC cis rs4704187 0.687 rs4704179 chr5:74457273 C/T cg03227963 chr5:74354835 NA 0.3 5.49 0.32 9.27e-8 Response to amphetamines; CESC cis rs929596 0.583 rs77070100 chr2:234587847 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -5.28 -0.31 2.75e-7 Total bilirubin levels in HIV-1 infection; CESC cis rs6500602 0.702 rs1051308 chr16:4560301 A/G cg08645402 chr16:4508243 NA -0.59 -9.72 -0.51 2.72e-19 Schizophrenia; CESC cis rs12142240 0.698 rs66972124 chr1:46807445 A/G cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg10691866 chr7:65817282 TPST1 -0.31 -5.16 -0.3 4.78e-7 Aortic root size; CESC cis rs10751667 0.666 rs7934963 chr11:957220 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.35 -0.31 1.89e-7 Alzheimer's disease (late onset); CESC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg18099408 chr3:52552593 STAB1 -0.3 -5.04 -0.3 8.71e-7 Bipolar disorder; CESC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg19257562 chr1:2043853 PRKCZ 0.41 6.68 0.38 1.37e-10 Height; CESC cis rs17253792 0.822 rs7145064 chr14:56088860 C/T cg01858014 chr14:56050164 KTN1 -0.91 -7.19 -0.4 6.43e-12 Putamen volume; CESC cis rs72781680 1.000 rs72798417 chr2:24188656 C/T cg08917208 chr2:24149416 ATAD2B 0.94 8.54 0.46 1.09e-15 Lymphocyte counts; CESC cis rs9522267 0.535 rs9522303 chr13:112237301 T/C cg10483660 chr13:112241077 NA -0.33 -5.78 -0.33 2.14e-8 Hepatitis; CESC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg10691866 chr7:65817282 TPST1 0.31 5.24 0.31 3.34e-7 Aortic root size; CESC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg27170947 chr2:26402098 FAM59B 0.87 9.89 0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs7264396 0.563 rs6060558 chr20:34271092 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.6 5.87 0.34 1.33e-8 Total cholesterol levels; CESC cis rs637571 0.607 rs574586 chr11:65697083 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 6.1 0.35 3.66e-9 Eosinophil percentage of white cells; CESC cis rs11690935 0.918 rs11757 chr2:172641045 C/G cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.95 -0.68 4.66e-37 Schizophrenia; CESC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs763121 0.886 rs1013339 chr22:38974680 C/T cg06544989 chr22:39130855 UNC84B 0.51 9.31 0.5 4.98e-18 Menopause (age at onset); CESC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg00738919 chr7:1100172 C7orf50 0.53 5.38 0.31 1.65e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg24675658 chr1:53192096 ZYG11B -0.6 -7.72 -0.43 2.43e-13 Monocyte count; CESC cis rs939658 0.805 rs11634903 chr15:79436192 C/T cg17916960 chr15:79447300 NA 0.35 5.9 0.34 1.12e-8 Refractive error; CESC cis rs9522267 0.502 rs9522297 chr13:112234419 C/T cg10483660 chr13:112241077 NA -0.33 -5.79 -0.33 2.04e-8 Hepatitis; CESC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg24733560 chr20:60626293 TAF4 0.41 5.91 0.34 1.04e-8 Body mass index; CESC cis rs7777484 0.534 rs2258709 chr7:2832365 C/T cg19717773 chr7:2847554 GNA12 0.66 11.33 0.57 1.63e-24 Height; CESC cis rs1707322 0.721 rs4559551 chr1:46167533 T/C cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.74e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7666738 0.830 rs1426670 chr4:98923572 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.21 0.6 1.68e-27 Colonoscopy-negative controls vs population controls; CESC trans rs1814175 0.935 rs7482690 chr11:49648814 C/T cg03929089 chr4:120376271 NA -0.85 -12.82 -0.62 1.34e-29 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14571620 chr12:123717888 C12orf65 0.48 6.31 0.36 1.16e-9 Gut microbiota (bacterial taxa); CESC cis rs733592 0.507 rs10747529 chr12:48473369 G/A cg24011408 chr12:48396354 COL2A1 -0.5 -8.24 -0.45 7.74e-15 Plateletcrit; CESC cis rs7116495 1.000 rs659513 chr11:71812411 C/T cg26138937 chr11:71823887 C11orf51 0.87 7.39 0.41 1.95e-12 Severe influenza A (H1N1) infection; CESC cis rs9611565 0.921 rs8137373 chr22:41729216 A/G cg03806693 chr22:41940476 POLR3H 0.85 9.58 0.51 7.31e-19 Vitiligo; CESC cis rs9925964 0.591 rs11649653 chr16:30918487 C/G cg00531865 chr16:30841666 NA 0.41 5.14 0.3 5.44e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.75e-12 Tonsillectomy; CESC cis rs870825 0.518 rs56034065 chr4:185655402 A/G cg07424746 chr4:185654737 MLF1IP -0.71 -5.19 -0.3 4.1e-7 Blood protein levels; CESC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg07256732 chr16:621771 PIGQ -0.3 -5.33 -0.31 2.07e-7 Height; CESC cis rs4642101 0.662 rs9874893 chr3:12833079 C/G cg05775895 chr3:12838266 CAND2 0.38 5.6 0.33 5.22e-8 QRS complex (12-leadsum); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12169852 chr17:57231726 SKA2;PRR11 -0.6 -7.44 -0.42 1.42e-12 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg07677032 chr17:61819896 STRADA 0.44 5.85 0.34 1.44e-8 Prudent dietary pattern; CESC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg23758822 chr17:41437982 NA 1.04 16.01 0.7 7.99e-41 Menopause (age at onset); CESC cis rs12048904 0.930 rs11166529 chr1:101333733 C/T cg15686842 chr1:101360669 SLC30A7;EXTL2 0.43 5.12 0.3 6e-7 Multiple sclerosis; CESC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg18230493 chr5:56204884 C5orf35 -0.74 -8.84 -0.48 1.37e-16 Initial pursuit acceleration; CESC cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.51 6.2 0.36 2.11e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.84 0.34 1.56e-8 Menopause (age at onset); CESC cis rs9905704 0.918 rs430973 chr17:56709206 T/G cg12560992 chr17:57184187 TRIM37 0.59 6.98 0.39 2.34e-11 Testicular germ cell tumor; CESC cis rs10129255 0.536 rs6576201 chr14:107139713 A/G cg23076370 chr14:107095027 NA 0.53 7.75 0.43 2e-13 Kawasaki disease; CESC cis rs2228479 0.850 rs2238527 chr16:89840708 C/A cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs748404 0.660 rs690012 chr15:43719755 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.21 0.45 9.85e-15 Lung cancer; CESC cis rs3096299 0.933 rs747485 chr16:89474094 T/C cg08392591 chr16:89556376 ANKRD11 0.4 5.12 0.3 5.82e-7 Multiple myeloma (IgH translocation); CESC cis rs2625529 0.878 rs2929511 chr15:72231682 C/T cg16672083 chr15:72433130 SENP8 0.43 6.45 0.37 5.37e-10 Red blood cell count; CESC cis rs1538970 0.781 rs34768551 chr1:46020408 G/A cg06784218 chr1:46089804 CCDC17 0.38 6.05 0.35 4.81e-9 Platelet count; CESC cis rs11048434 0.723 rs1805737 chr12:9084670 A/T cg23795048 chr12:9217529 LOC144571 0.36 5.68 0.33 3.53e-8 Sjögren's syndrome; CESC cis rs4076764 1.000 rs4076764 chr1:163441286 A/G cg06092702 chr1:163392909 NA -0.36 -5.25 -0.31 3.1e-7 Motion sickness; CESC cis rs3820928 0.874 rs4423583 chr2:227874957 A/G cg11843606 chr2:227700838 RHBDD1 0.47 6.06 0.35 4.66e-9 Pulmonary function; CESC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg14664628 chr15:75095509 CSK -0.43 -5.34 -0.31 2.01e-7 Caffeine consumption; CESC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg21144161 chr5:423903 AHRR 0.37 6.14 0.35 2.96e-9 Cystic fibrosis severity; CESC cis rs9527 0.590 rs11191513 chr10:104772984 T/G cg04362960 chr10:104952993 NT5C2 0.4 5.1 0.3 6.39e-7 Arsenic metabolism; CESC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.67 8.91 0.48 8.58e-17 Total body bone mineral density; CESC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg04166393 chr7:2884313 GNA12 0.59 7.37 0.41 2.2e-12 Height; CESC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg06481639 chr22:41940642 POLR3H -0.66 -6.62 -0.38 2e-10 Crohn's disease;Inflammatory bowel disease; CESC trans rs802075 0.905 rs9395522 chr6:49637975 T/A cg06254729 chr2:28550422 BRE -0.36 -6.13 -0.35 3.23e-9 Bone mineral density (hip) and age at menarche; CESC cis rs17826219 0.568 rs59858012 chr17:29078582 C/T cg13385521 chr17:29058706 SUZ12P 0.84 6.04 0.35 5.22e-9 Body mass index; CESC cis rs3806843 1.000 rs6579987 chr5:140183659 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.26 -0.31 2.95e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7385804 0.796 rs10277087 chr7:100307538 C/G cg20848291 chr7:100343083 ZAN 0.51 6.93 0.39 3.12e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs7923609 0.967 rs7076310 chr10:65135672 C/A cg01631684 chr10:65280961 REEP3 -0.42 -5.18 -0.3 4.35e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs8058578 1.000 rs2289442 chr16:30739919 A/G cg02466173 chr16:30829666 NA -0.46 -7.33 -0.41 2.71e-12 Multiple myeloma; CESC cis rs12618769 0.597 rs10496327 chr2:99066827 A/G cg10123293 chr2:99228465 UNC50 0.39 5.07 0.3 7.32e-7 Bipolar disorder; CESC cis rs7959452 0.640 rs11177599 chr12:69721970 G/A cg20891283 chr12:69753455 YEATS4 0.77 11.28 0.57 2.4e-24 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00082540 chr21:46396774 C21orf70 -0.53 -6.38 -0.36 8.05e-10 Gut microbiome composition (summer); CESC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg11644478 chr21:40555479 PSMG1 1.05 16.84 0.72 9.02e-44 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01857591 chr8:81083836 TPD52 0.57 6.13 0.35 3.09e-9 Gut microbiome composition (summer); CESC cis rs2290159 0.800 rs9849807 chr3:12675026 A/G cg23032965 chr3:12705835 RAF1 0.54 5.7 0.33 3.23e-8 Cholesterol, total; CESC cis rs4595586 0.545 rs12819061 chr12:39386976 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs2108622 0.727 rs62107764 chr19:15982658 A/G cg13772218 chr19:15982569 NA 0.29 5.8 0.34 1.85e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs4642101 0.597 rs9839769 chr3:12821405 C/T cg24848339 chr3:12840334 CAND2 0.39 6.1 0.35 3.65e-9 QRS complex (12-leadsum); CESC cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg24308560 chr3:49941425 MST1R 0.58 8.37 0.46 3.27e-15 Body mass index; CESC cis rs6694270 0.529 rs12565650 chr1:19108355 G/A cg26220594 chr1:19110978 NA -0.39 -5.03 -0.3 9.18e-7 Drug-induced liver injury (nitrofurantoin); CESC cis rs568617 0.953 rs1151519 chr11:65645831 G/C cg04055107 chr11:65626734 MUS81;CFL1 -0.69 -7.4 -0.41 1.81e-12 Crohn's disease; CESC cis rs34375054 1.000 rs34375054 chr12:125665896 A/T cg25124228 chr12:125621409 AACS -0.47 -6.09 -0.35 4.03e-9 Post bronchodilator FEV1/FVC ratio; CESC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg18876405 chr7:65276391 NA -0.55 -6.01 -0.35 6.19e-9 Aortic root size; CESC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg16489826 chr6:160211363 TCP1;MRPL18 0.78 9.64 0.51 4.81e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg10691866 chr7:65817282 TPST1 0.33 5.5 0.32 8.83e-8 Aortic root size; CESC cis rs79839061 0.610 rs11732965 chr4:869359 C/A cg07828340 chr4:882639 GAK 1.07 8.28 0.45 6.09e-15 Intelligence (multi-trait analysis); CESC cis rs9796 0.745 rs2947493 chr15:41375694 G/A cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.28 -0.36 1.39e-9 Menopause (age at onset); CESC cis rs6502050 0.835 rs11077981 chr17:80147243 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.59e-10 Life satisfaction; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg25276849 chr3:195808919 TFRC -0.55 -6.28 -0.36 1.42e-9 Subjective well-being; CESC cis rs1797885 0.902 rs905644 chr3:12530828 C/T cg26432171 chr3:12704882 RAF1 -0.48 -5.97 -0.34 7.75e-9 Immature fraction of reticulocytes; CESC cis rs17253792 0.822 rs10137364 chr14:56059987 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.79 -0.38 7.45e-11 Putamen volume; CESC cis rs10911251 0.528 rs10911265 chr1:183115071 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 13.53 0.64 4.76e-32 Colorectal cancer; CESC cis rs10752881 1.000 rs6424879 chr1:182986592 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.3 0.63 2.79e-31 Colorectal cancer; CESC cis rs16867321 0.627 rs13411336 chr2:181588696 A/G cg23363182 chr2:181467187 NA -0.44 -5.74 -0.33 2.59e-8 Obesity; CESC cis rs12541635 0.966 rs12550587 chr8:106978289 C/T cg10147462 chr8:107024639 NA 0.39 5.37 0.31 1.69e-7 Age of smoking initiation; CESC cis rs10751667 0.621 rs7394681 chr11:952111 C/T cg01483505 chr11:975446 AP2A2 0.37 5.05 0.3 8.23e-7 Alzheimer's disease (late onset); CESC cis rs10927875 0.894 rs34957618 chr1:16320499 G/C cg22431228 chr1:16359049 CLCNKA 0.35 5.76 0.33 2.38e-8 Dilated cardiomyopathy; CESC cis rs826838 0.967 rs1719856 chr12:39127201 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.53e-9 Heart rate; CESC cis rs3733585 0.648 rs35954357 chr4:9978758 G/C cg02734326 chr4:10020555 SLC2A9 0.41 5.84 0.34 1.51e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7208859 0.573 rs58920731 chr17:29191746 G/T cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs35110281 0.837 rs7279958 chr21:45016016 C/A cg01579765 chr21:45077557 HSF2BP -0.58 -10.09 -0.53 1.83e-20 Mean corpuscular volume; CESC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg03609598 chr5:56110824 MAP3K1 -0.51 -5.41 -0.32 1.43e-7 Initial pursuit acceleration; CESC cis rs2302190 0.769 rs6503864 chr17:56549671 C/A cg25885038 chr17:56607967 SEPT4 -0.41 -5.38 -0.31 1.67e-7 Vitamin D levels; CESC cis rs8114671 0.562 rs2889861 chr20:33405664 C/T cg07148914 chr20:33460835 GGT7 0.42 5.59 0.32 5.73e-8 Height; CESC cis rs6835098 0.887 rs12644699 chr4:174142874 A/G cg08422745 chr4:174089978 GALNT7 0.63 7.67 0.43 3.31e-13 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg11764359 chr7:65958608 NA 0.82 9.37 0.5 3.25e-18 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02850329 chr1:24829455 RCAN3 0.52 6.0 0.35 6.36e-9 Gut microbiome composition (summer); CESC cis rs714031 0.934 rs4820387 chr22:40070446 A/G cg21377881 chr22:40064566 CACNA1I -0.34 -5.39 -0.31 1.55e-7 Schizophrenia; CESC cis rs2228479 0.867 rs17784386 chr16:89947457 A/G cg04013166 chr16:89971882 TCF25 0.77 7.14 0.4 8.86e-12 Skin colour saturation; CESC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg21433313 chr16:3507492 NAT15 0.64 6.92 0.39 3.43e-11 Tuberculosis; CESC cis rs77956314 0.515 rs60940473 chr12:117462582 C/T cg25972092 chr12:117363249 FBXW8 -0.53 -5.56 -0.32 6.66e-8 Subcortical brain region volumes;Hippocampal volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17999743 chr8:38239693 WHSC1L1 -0.44 -6.03 -0.35 5.57e-9 Fibrinogen levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19098314 chr17:28804347 GOSR1 0.46 6.68 0.38 1.43e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs60843830 0.661 rs55987018 chr2:106655 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.51 6.08 0.35 4.21e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs362296 0.698 rs3095081 chr4:3263776 C/T cg08886695 chr4:3369023 RGS12 0.36 5.06 0.3 7.84e-7 Parental longevity (mother's age at death); CESC cis rs854765 0.547 rs9913277 chr17:17919749 G/T cg16928487 chr17:17741425 SREBF1 -0.59 -10.42 -0.54 1.59e-21 Total body bone mineral density; CESC cis rs6977955 1.000 rs2893312 chr7:28170403 C/T cg23620719 chr7:28220237 JAZF1 -0.58 -6.52 -0.37 3.6e-10 Allergic disease (asthma, hay fever or eczema); CESC trans rs16946160 0.718 rs9589279 chr13:92185178 G/A cg09924998 chr12:122751933 VPS33A 0.52 6.03 0.35 5.46e-9 Nephrotic syndrome (acquired); CESC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg26338869 chr17:61819248 STRADA 0.73 9.65 0.51 4.47e-19 Prudent dietary pattern; CESC cis rs1707322 0.717 rs2991988 chr1:46082431 C/A cg06784218 chr1:46089804 CCDC17 -0.41 -7.08 -0.4 1.31e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504073 0.584 rs7818507 chr8:49918423 G/T cg00325661 chr8:49890786 NA 0.53 8.13 0.45 1.62e-14 Blood metabolite ratios; CESC cis rs36051895 0.632 rs10974980 chr9:5140671 C/G cg02405213 chr9:5042618 JAK2 -0.5 -6.07 -0.35 4.52e-9 Pediatric autoimmune diseases; CESC cis rs8008758 1.000 rs12432879 chr14:101688977 A/G cg26224664 chr14:101693935 NA 0.35 5.6 0.33 5.48e-8 Body mass index (alcohol intake interaction); CESC cis rs2860975 0.542 rs1579029 chr10:96811010 T/C cg09036531 chr10:96991505 NA -0.36 -5.22 -0.31 3.61e-7 Immune response to smallpox vaccine (IL-6); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14657458 chr10:134469026 INPP5A 0.44 6.28 0.36 1.41e-9 Fibrinogen levels; CESC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg17724175 chr1:150552817 MCL1 0.44 7.16 0.4 8.15e-12 Tonsillectomy; CESC cis rs2777491 0.872 rs7176588 chr15:41588872 C/T cg02330683 chr15:41787940 ITPKA 0.42 6.18 0.35 2.45e-9 Ulcerative colitis; CESC cis rs7130144 0.541 rs7925596 chr11:130463610 C/G cg26307797 chr11:130446613 NA -0.8 -6.65 -0.38 1.64e-10 Urate levels in lean individuals; CESC cis rs7267979 1.000 rs2424713 chr20:25418482 C/T cg08601574 chr20:25228251 PYGB 0.35 5.04 0.3 8.82e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs56104184 0.725 rs4347731 chr19:49385154 A/G cg15549821 chr19:49342101 PLEKHA4 -0.59 -5.46 -0.32 1.07e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs2204008 0.805 rs7296063 chr12:37964775 T/G cg26384229 chr12:38710491 ALG10B 0.73 10.68 0.55 2.17e-22 Bladder cancer; CESC cis rs11190604 0.943 rs7900678 chr10:102229016 T/C cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.47 0.42 1.19e-12 Prudent dietary pattern; CESC cis rs9660992 0.710 rs1668872 chr1:205236069 G/A cg21643547 chr1:205240462 TMCC2 -0.47 -6.34 -0.36 1.01e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs79349575 0.811 rs1057897 chr17:47005509 T/G cg26022315 chr17:47021804 SNF8 0.38 5.06 0.3 7.79e-7 Type 2 diabetes; CESC cis rs3793683 1.000 rs3793683 chr10:134568387 G/T cg26818010 chr10:134567672 INPP5A 0.51 6.3 0.36 1.2e-9 Migraine; CESC cis rs2235649 0.798 rs9932983 chr16:1848184 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.41 -5.04 -0.3 8.48e-7 Blood metabolite levels; CESC cis rs763121 0.853 rs9622833 chr22:39000397 G/A cg14440974 chr22:39074834 NA -0.4 -5.32 -0.31 2.22e-7 Menopause (age at onset); CESC cis rs832540 0.593 rs96844 chr5:56196604 G/A cg24531977 chr5:56204891 C5orf35 -0.51 -6.31 -0.36 1.17e-9 Coronary artery disease; CESC cis rs3820928 0.874 rs9288618 chr2:227872617 A/G cg05526886 chr2:227700861 RHBDD1 -0.43 -5.5 -0.32 8.97e-8 Pulmonary function; CESC cis rs854765 0.583 rs9635697 chr17:17870394 T/A cg04398451 chr17:18023971 MYO15A -0.7 -9.85 -0.52 1.04e-19 Total body bone mineral density; CESC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg15445000 chr17:37608096 MED1 0.41 6.87 0.39 4.66e-11 Glomerular filtration rate (creatinine); CESC cis rs2011503 0.882 rs72999053 chr19:19375372 G/A cg11584989 chr19:19387371 SF4 0.63 7.58 0.42 5.75e-13 Bipolar disorder; CESC cis rs1153858 0.945 rs7182300 chr15:45634928 G/A cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs516243 0.841 rs6540944 chr1:10740405 C/T cg02903756 chr1:10750680 CASZ1 -0.39 -5.6 -0.33 5.27e-8 Migraine - clinic-based; CESC cis rs634534 0.563 rs470192 chr11:65724291 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.48 6.51 0.37 3.66e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg02896835 chr1:92012615 NA -0.53 -6.78 -0.38 7.89e-11 Breast cancer; CESC cis rs2290159 0.752 rs5746182 chr3:12672550 A/G cg23032965 chr3:12705835 RAF1 0.53 5.68 0.33 3.63e-8 Cholesterol, total; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22622495 chr1:91966418 CDC7 -0.43 -6.2 -0.36 2.18e-9 Fibrinogen levels; CESC cis rs3015497 0.583 rs12881560 chr14:51018253 A/G cg26011998 chr14:51135199 SAV1 0.47 5.36 0.31 1.8e-7 Mean platelet volume; CESC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.64 0.33 4.33e-8 Bipolar disorder; CESC cis rs1707322 0.963 rs10890373 chr1:46393755 A/C cg06784218 chr1:46089804 CCDC17 0.37 6.37 0.36 8.5e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1124376 1.000 rs9819739 chr3:20140760 G/A cg05072819 chr3:20081367 KAT2B 0.49 5.55 0.32 7e-8 Bipolar disorder and schizophrenia; CESC cis rs8002861 0.846 rs12869355 chr13:44478193 A/C cg19180546 chr13:44453867 C13orf31;CCDC122 0.44 5.63 0.33 4.56e-8 Leprosy; CESC cis rs765787 0.530 rs11636018 chr15:45539137 T/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs11577318 0.853 rs7537477 chr1:26618829 C/T cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.37 -0.36 8.2e-10 Granulocyte percentage of myeloid white cells; CESC cis rs3820928 0.904 rs2217359 chr2:227759892 C/T cg05526886 chr2:227700861 RHBDD1 -0.43 -5.47 -0.32 1.02e-7 Pulmonary function; CESC trans rs7335046 0.901 rs72649510 chr13:99957621 C/T cg14259717 chr11:18433732 LDHC 0.64 6.26 0.36 1.56e-9 Basal cell carcinoma; CESC cis rs7264396 0.635 rs7263302 chr20:34545858 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.57 6.97 0.39 2.48e-11 Total cholesterol levels; CESC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg14393609 chr7:65229607 NA -0.46 -6.14 -0.35 3.03e-9 Aortic root size; CESC trans rs7618501 0.966 rs9882639 chr3:49799475 A/C cg21659725 chr3:3221576 CRBN 0.83 13.56 0.64 3.67e-32 Intelligence (multi-trait analysis); CESC cis rs1018836 0.770 rs12543806 chr8:91664011 C/T cg16814680 chr8:91681699 NA -0.89 -13.93 -0.65 1.85e-33 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg17340268 chr14:105411764 AHNAK2 -0.52 -6.91 -0.39 3.56e-11 Rheumatoid arthritis; CESC cis rs6964587 0.620 rs6967588 chr7:91643402 G/T cg01689657 chr7:91764605 CYP51A1 0.26 5.04 0.3 8.66e-7 Breast cancer; CESC trans rs1973993 0.567 rs2800433 chr1:96998126 T/A cg10631902 chr5:14652156 NA 0.47 7.05 0.4 1.54e-11 Weight; CESC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg04369109 chr6:150039330 LATS1 -0.41 -5.54 -0.32 7.2e-8 Lung cancer; CESC cis rs9916302 0.898 rs8072297 chr17:37478048 A/T cg07936489 chr17:37558343 FBXL20 0.79 11.03 0.56 1.52e-23 Glomerular filtration rate (creatinine); CESC cis rs829883 0.664 rs865509 chr12:98854444 T/A cg25150519 chr12:98850993 NA 0.87 14.67 0.67 4.52e-36 Colorectal adenoma (advanced); CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg07092213 chr7:1199455 ZFAND2A -0.44 -5.9 -0.34 1.08e-8 Longevity;Endometriosis; CESC cis rs8060686 0.668 rs255056 chr16:68016185 G/C cg26727032 chr16:67993705 SLC12A4 -0.5 -5.73 -0.33 2.68e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg10494973 chr17:80897199 TBCD 0.46 5.97 0.34 7.4e-9 Breast cancer; CESC cis rs965469 1.000 rs6051779 chr20:3333449 A/G cg25506879 chr20:3388711 C20orf194 -0.55 -5.87 -0.34 1.31e-8 IFN-related cytopenia; CESC cis rs992157 0.735 rs2271541 chr2:219082119 G/T cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.61 0.51 5.92e-19 Colorectal cancer; CESC cis rs7605378 1.000 rs2346662 chr2:200679158 C/T cg23649088 chr2:200775458 C2orf69 0.5 6.28 0.36 1.36e-9 Osteoporosis; CESC cis rs7809799 0.850 rs10248890 chr7:98752384 A/G cg05967295 chr7:98741636 SMURF1 -0.77 -5.56 -0.32 6.74e-8 Ulcerative colitis; CESC cis rs8077577 0.848 rs12600694 chr17:18091019 C/T cg16794390 chr17:18148240 FLII 0.4 5.65 0.33 4.19e-8 Obesity-related traits; CESC cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg19723775 chr5:179050963 HNRNPH1 0.41 5.37 0.31 1.76e-7 Lung cancer; CESC cis rs7044106 0.762 rs3904197 chr9:123480378 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.23 0.53 6.35e-21 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20811730 chr1:150293902 PRPF3 0.61 6.77 0.38 8.17e-11 Gut microbiome composition (summer); CESC cis rs6542838 0.582 rs6542845 chr2:99537600 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.52 -6.64 -0.38 1.81e-10 Fear of minor pain; CESC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.49 0.42 1.01e-12 Prudent dietary pattern; CESC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg07701084 chr6:150067640 NUP43 0.45 5.75 0.33 2.48e-8 Lung cancer; CESC cis rs7923609 0.967 rs6479896 chr10:65126832 T/C cg01631684 chr10:65280961 REEP3 -0.42 -5.17 -0.3 4.66e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs929354 1.000 rs1182414 chr7:157058363 G/A cg05182265 chr7:156933206 UBE3C 0.45 6.24 0.36 1.71e-9 Body mass index; CESC cis rs2251381 0.565 rs2832279 chr21:30613466 G/T cg08807101 chr21:30365312 RNF160 0.53 6.2 0.36 2.21e-9 Selective IgA deficiency; CESC cis rs11078917 1 rs11078917 chr17:37746359 A/C cg20243544 chr17:37824526 PNMT 0.56 6.87 0.39 4.69e-11 Mean corpuscular volume; CESC cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg27121462 chr16:89883253 FANCA -0.5 -6.32 -0.36 1.11e-9 Vitiligo; CESC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 10.58 0.54 4.7e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.01 0.4 2e-11 Bipolar disorder; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg03811519 chr9:134001305 NUP214 0.49 6.79 0.38 7.46e-11 Obesity-related traits; CESC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 8.54 0.46 1.04e-15 Platelet count; CESC cis rs9815354 0.680 rs112310714 chr3:42024797 A/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16702713 chr5:118407037 DMXL1 -0.42 -6.32 -0.36 1.07e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.95 10.57 0.54 4.97e-22 Platelet count; CESC cis rs8062405 1.000 rs4451951 chr16:28836205 T/C cg08761264 chr16:28874980 SH2B1 -0.47 -5.91 -0.34 1.07e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs748404 0.631 rs28702649 chr15:43648629 C/T cg24053811 chr14:70265306 SLC10A1 0.45 6.26 0.36 1.55e-9 Lung cancer; CESC cis rs9926296 0.609 rs4785714 chr16:89798404 G/T cg27121462 chr16:89883253 FANCA -0.63 -8.12 -0.45 1.82e-14 Vitiligo; CESC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg12756686 chr19:29218302 NA 0.58 7.52 0.42 8.38e-13 Methadone dose in opioid dependence; CESC cis rs2286503 0.650 rs1990279 chr7:22890742 A/G cg13679077 chr7:22862647 TOMM7 0.4 5.03 0.3 9.08e-7 Fibrinogen; CESC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg03576123 chr11:487126 PTDSS2 -1.1 -11.08 -0.56 1.11e-23 Body mass index; CESC cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg18357645 chr12:58087776 OS9 -0.41 -5.77 -0.33 2.25e-8 Multiple sclerosis; CESC cis rs10465746 0.570 rs12402130 chr1:84479838 G/A cg10977910 chr1:84465055 TTLL7 0.45 5.79 0.34 1.98e-8 Obesity-related traits; CESC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg22800045 chr5:56110881 MAP3K1 0.83 9.98 0.52 3.92e-20 Initial pursuit acceleration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24689585 chr15:22957012 CYFIP1 0.44 6.37 0.36 8.48e-10 Fibrinogen levels; CESC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg06074448 chr4:187884817 NA -0.36 -5.04 -0.3 8.76e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.846 rs2892453 chr6:146377717 C/A cg23711669 chr6:146136114 FBXO30 0.77 11.36 0.57 1.24e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs7927592 0.956 rs2155730 chr11:68329474 T/C cg16797656 chr11:68205561 LRP5 0.39 5.39 0.31 1.57e-7 Total body bone mineral density; CESC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 20.91 0.79 5.34e-58 Prudent dietary pattern; CESC cis rs7809950 0.906 rs2395907 chr7:107253304 A/G cg23024343 chr7:107201750 COG5 0.46 6.19 0.36 2.23e-9 Coronary artery disease; CESC cis rs9487051 0.714 rs6902892 chr6:109627601 G/T cg12927641 chr6:109611667 NA -0.36 -5.31 -0.31 2.31e-7 Reticulocyte fraction of red cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25937155 chr17:20408772 MGC102966 0.39 6.15 0.35 2.82e-9 Fibrinogen levels; CESC cis rs722599 0.748 rs55707505 chr14:75362552 T/C cg11812906 chr14:75593930 NEK9 -0.45 -5.52 -0.32 8.19e-8 IgG glycosylation; CESC cis rs9486719 1.000 rs3798296 chr6:97052286 G/A cg06623918 chr6:96969491 KIAA0776 -0.83 -8.65 -0.47 5.09e-16 Migraine;Coronary artery disease; CESC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg25517755 chr10:38738941 LOC399744 0.5 6.52 0.37 3.63e-10 Extrinsic epigenetic age acceleration; CESC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg22907277 chr7:1156413 C7orf50 0.5 5.96 0.34 8.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg05343316 chr1:45956843 TESK2 -0.51 -6.5 -0.37 3.93e-10 High light scatter reticulocyte count; CESC cis rs933688 1.000 rs11950530 chr5:90688740 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 14.27 0.66 1.16e-34 Smoking behavior; CESC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs11871801 0.541 rs4793090 chr17:40686342 G/A cg14558262 chr17:40713999 COASY -0.43 -5.22 -0.31 3.58e-7 Crohn's disease; CESC cis rs9768139 0.733 rs13309408 chr7:158122261 C/T cg06219351 chr7:158114137 PTPRN2 -0.53 -8.18 -0.45 1.16e-14 Calcium levels; CESC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg14829155 chr15:31115871 NA -0.69 -9.17 -0.49 1.34e-17 Huntington's disease progression; CESC cis rs10200159 1.000 rs10195281 chr2:55848021 C/T cg13617705 chr2:55845095 SMEK2 0.78 5.46 0.32 1.11e-7 Vitiligo; CESC cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg10523679 chr1:76189770 ACADM -0.65 -6.61 -0.38 2.12e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7216064 1.000 rs73352808 chr17:65875157 G/A cg07042672 chr17:66097459 LOC651250 -0.54 -6.04 -0.35 5.12e-9 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg13147721 chr7:65941812 NA 0.37 5.04 0.3 8.53e-7 Aortic root size; CESC cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg19729930 chr2:74357872 NA 0.84 12.54 0.61 1.2e-28 Gestational age at birth (maternal effect); CESC cis rs2730245 0.527 rs842700 chr7:158697565 G/A cg24397884 chr7:158709396 WDR60 0.86 8.92 0.48 7.93e-17 Height; CESC cis rs6430585 0.591 rs12477421 chr2:136433740 A/G cg07169764 chr2:136633963 MCM6 1.17 13.25 0.63 4.42e-31 Corneal structure; CESC cis rs3749237 0.595 rs6797765 chr3:49423976 A/G cg06212747 chr3:49208901 KLHDC8B 0.49 6.6 0.38 2.22e-10 Resting heart rate; CESC cis rs11676348 0.846 rs4674257 chr2:218988774 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.03 -0.35 5.37e-9 Ulcerative colitis; CESC cis rs4780401 0.609 rs8055247 chr16:11827543 G/A cg01061890 chr16:11836724 TXNDC11 -0.54 -7.41 -0.41 1.7e-12 Rheumatoid arthritis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11376330 chr3:49131570 QRICH1 -0.42 -6.0 -0.35 6.46e-9 Gambling; CESC cis rs1348850 0.668 rs6705405 chr2:178493713 A/G cg22681709 chr2:178499509 PDE11A -0.41 -5.9 -0.34 1.09e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2204008 0.537 rs11170128 chr12:38006632 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.77 0.55 1.12e-22 Bladder cancer; CESC cis rs708547 0.836 rs1612191 chr4:57724320 A/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.56 -6.25 -0.36 1.67e-9 Response to bleomycin (chromatid breaks); CESC cis rs2204008 0.580 rs11174421 chr12:38105138 A/G cg13010199 chr12:38710504 ALG10B 0.52 6.23 0.36 1.82e-9 Bladder cancer; CESC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg07308232 chr7:1071921 C7orf50 -0.56 -8.07 -0.44 2.4e-14 Longevity;Endometriosis; CESC cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.59 5.72 0.33 2.89e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12971120 0.947 rs7241558 chr18:72169267 A/T cg25817165 chr18:72167213 CNDP2 -0.56 -7.72 -0.43 2.31e-13 Refractive error; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03305624 chr19:17283537 MYO9B 0.49 6.72 0.38 1.12e-10 Fibrinogen levels; CESC cis rs425277 0.606 rs3128295 chr1:2068480 C/T cg24578937 chr1:2090814 PRKCZ -0.35 -5.97 -0.34 7.8e-9 Height; CESC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg08027265 chr7:2291960 NA -0.34 -5.08 -0.3 7.07e-7 Bipolar disorder and schizophrenia; CESC cis rs3796352 1.000 rs2564926 chr3:53094730 G/A cg15956490 chr3:53032818 SFMBT1 -0.61 -5.46 -0.32 1.09e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs9611565 0.546 rs5758426 chr22:42098763 T/G cg17376030 chr22:41985996 PMM1 -0.45 -5.15 -0.3 5.21e-7 Vitiligo; CESC cis rs8077889 0.917 rs6503479 chr17:41917003 A/G cg26893861 chr17:41843967 DUSP3 0.74 9.8 0.52 1.52e-19 Triglycerides; CESC cis rs7584330 0.784 rs6724766 chr2:238413600 A/G cg14458575 chr2:238380390 NA 0.54 7.28 0.41 3.85e-12 Prostate cancer; CESC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg08027265 chr7:2291960 NA -0.45 -6.94 -0.39 2.96e-11 Bipolar disorder and schizophrenia; CESC cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs1707322 0.721 rs6697821 chr1:46216722 A/G cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg20503657 chr10:835505 NA 0.76 7.62 0.42 4.63e-13 Eosinophil percentage of granulocytes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12473036 chr20:62611207 SAMD10;PRPF6 -0.45 -6.36 -0.36 8.93e-10 Gambling; CESC cis rs3747547 0.710 rs16934658 chr9:37950543 C/A cg13774184 chr9:37916125 SHB -0.57 -5.83 -0.34 1.57e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs9443645 0.527 rs12194642 chr6:79538791 G/A cg05283184 chr6:79620031 NA -0.37 -5.43 -0.32 1.28e-7 Intelligence (multi-trait analysis); CESC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.71e-40 Aortic root size; CESC cis rs2425143 1.000 rs73902908 chr20:34365112 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 8.09e-12 Blood protein levels; CESC cis rs1461503 0.903 rs7124683 chr11:122834036 A/G cg27398637 chr11:122830231 C11orf63 0.51 7.28 0.41 3.89e-12 Menarche (age at onset); CESC cis rs11997175 0.646 rs4612298 chr8:33713451 G/A ch.8.33884649F chr8:33765107 NA 0.55 7.36 0.41 2.26e-12 Body mass index; CESC cis rs7560272 0.723 rs4852927 chr2:73641557 C/T cg20560298 chr2:73613845 ALMS1 0.5 7.17 0.4 7.57e-12 Schizophrenia; CESC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg22535103 chr8:58192502 C8orf71 -0.93 -10.31 -0.53 3.63e-21 Developmental language disorder (linguistic errors); CESC cis rs2276314 1.000 rs2298715 chr18:33552425 T/C cg19628046 chr18:33552617 C18orf21 0.6 6.75 0.38 9.53e-11 Endometriosis;Drug-induced torsades de pointes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14195377 chr11:60928647 VPS37C 0.68 8.03 0.44 3.23e-14 Gut microbiome composition (summer); CESC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg00310523 chr12:86230176 RASSF9 0.41 6.17 0.35 2.61e-9 Major depressive disorder; CESC cis rs11048434 0.736 rs12424026 chr12:9110993 T/C cg23795048 chr12:9217529 LOC144571 0.35 5.35 0.31 1.9e-7 Sjögren's syndrome; CESC cis rs1707322 0.721 rs4431884 chr1:46101323 C/T cg05343316 chr1:45956843 TESK2 0.5 6.34 0.36 9.93e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9287719 0.967 rs6744599 chr2:10747013 C/G cg02196655 chr2:10830764 NOL10 0.37 5.66 0.33 3.86e-8 Prostate cancer; CESC cis rs7615952 0.515 rs4267608 chr3:125680500 C/T cg05084668 chr3:125655381 ALG1L -0.52 -5.77 -0.33 2.19e-8 Blood pressure (smoking interaction); CESC cis rs703842 1.000 rs8181644 chr12:58173466 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.72 9.31 0.5 5.09e-18 Multiple sclerosis; CESC cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 12.9 0.62 7.29e-30 Personality dimensions; CESC cis rs5757676 1.000 rs5757676 chr22:39841700 T/C cg05872129 chr22:39784769 NA -0.83 -8.92 -0.48 7.69e-17 IgG glycosylation; CESC cis rs17376456 0.877 rs13153245 chr5:93374891 G/A cg21475434 chr5:93447410 FAM172A 0.77 6.95 0.39 2.86e-11 Diabetic retinopathy; CESC cis rs4919694 0.611 rs7091462 chr10:104948615 C/T cg04362960 chr10:104952993 NT5C2 0.64 6.38 0.36 7.81e-10 Arsenic metabolism; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg01172785 chr16:50092553 NA -0.49 -6.23 -0.36 1.85e-9 Breast cancer;Type 2 diabetes; CESC trans rs35110281 0.837 rs7279968 chr21:45077398 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 6.75 0.38 9.14e-11 Mean corpuscular volume; CESC cis rs9287719 0.601 rs12995465 chr2:10716828 G/A cg00105475 chr2:10696890 NA 0.39 5.33 0.31 2.1e-7 Prostate cancer; CESC cis rs2820315 0.540 rs10920259 chr1:201797696 C/T cg11586189 chr1:201857591 SHISA4 -0.32 -5.37 -0.31 1.75e-7 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; CESC cis rs8180040 0.932 rs11712445 chr3:47434552 T/C cg27129171 chr3:47204927 SETD2 0.63 9.65 0.51 4.34e-19 Colorectal cancer; CESC cis rs1801251 1.000 rs6746294 chr2:233583050 C/G cg08000102 chr2:233561755 GIGYF2 -0.65 -8.62 -0.47 6.18e-16 Coronary artery disease; CESC cis rs2180341 0.781 rs7760652 chr6:127572096 A/G cg24812749 chr6:127587940 RNF146 0.84 11.79 0.59 4.6e-26 Breast cancer; CESC cis rs4132509 0.948 rs12032342 chr1:243834360 G/A cg21452805 chr1:244014465 NA 0.52 5.72 0.33 2.91e-8 RR interval (heart rate); CESC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg15595755 chr5:1867978 NA 0.51 8.38 0.46 3.17e-15 Cardiovascular disease risk factors; CESC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg18350739 chr11:68623251 NA -0.44 -6.81 -0.39 6.64e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4237845 0.537 rs7312623 chr12:58262523 G/T cg04478727 chr12:58166393 METTL1;FAM119B 0.51 5.74 0.33 2.63e-8 Intelligence (multi-trait analysis); CESC cis rs6582630 0.638 rs12424222 chr12:38548273 C/T cg26384229 chr12:38710491 ALG10B -0.42 -5.67 -0.33 3.67e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.46 5.74 0.33 2.61e-8 Tonsillectomy; CESC cis rs5758511 0.524 rs738257 chr22:42569298 C/A cg00645731 chr22:42541494 CYP2D7P1 0.59 8.76 0.47 2.3e-16 Birth weight; CESC cis rs10791097 0.720 rs6590515 chr11:130733365 A/G cg09137382 chr11:130731461 NA -0.34 -5.03 -0.3 8.92e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2806561 0.808 rs2235546 chr1:23409538 A/G cg12483005 chr1:23474871 LUZP1 0.34 5.33 0.31 2.15e-7 Height; CESC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg19592336 chr6:28129416 ZNF389 0.42 6.09 0.35 3.89e-9 Cardiac Troponin-T levels; CESC cis rs35110281 0.720 rs162376 chr21:44926759 G/T cg21573476 chr21:45109991 RRP1B 0.44 6.06 0.35 4.74e-9 Mean corpuscular volume; CESC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg13628971 chr7:2884303 GNA12 0.42 5.56 0.32 6.68e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.524 rs7122182 chr11:47843133 A/C cg18512352 chr11:47633146 NA -0.36 -5.55 -0.32 6.84e-8 Subjective well-being; CESC cis rs6582630 0.554 rs7299735 chr12:38450890 A/C cg26384229 chr12:38710491 ALG10B -0.42 -5.52 -0.32 8.27e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg14393609 chr7:65229607 NA 0.48 6.5 0.37 4e-10 Aortic root size; CESC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg22920501 chr2:26401640 FAM59B -0.67 -8.01 -0.44 3.53e-14 Gut microbiome composition (summer); CESC cis rs11098499 0.865 rs4507344 chr4:120307485 C/A cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs12451471 0.529 rs2278620 chr17:78083565 G/A cg24585782 chr17:78113791 EIF4A3 -0.58 -7.65 -0.43 3.63e-13 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs10751667 0.643 rs10794343 chr11:925493 C/T cg06064525 chr11:970664 AP2A2 -0.51 -10.06 -0.53 2.19e-20 Alzheimer's disease (late onset); CESC cis rs116095464 1.000 rs56075848 chr5:308352 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.64 5.08 0.3 7.3e-7 Breast cancer; CESC cis rs2204008 0.694 rs11179394 chr12:38210389 A/G cg26384229 chr12:38710491 ALG10B -0.42 -5.72 -0.33 2.93e-8 Bladder cancer; CESC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg22105103 chr4:187893119 NA 0.5 7.32 0.41 2.98e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs12048904 0.964 rs12027668 chr1:101330984 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 6.54 0.37 3.12e-10 Multiple sclerosis; CESC cis rs698833 0.624 rs7564087 chr2:44693647 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.42 5.59 0.32 5.64e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg13798912 chr7:905769 UNC84A 0.52 5.16 0.3 4.9e-7 Cerebrospinal P-tau181p levels; CESC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg04772025 chr11:68637568 NA 0.58 6.66 0.38 1.61e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1443512 0.588 rs3759162 chr12:54331154 G/C cg17410650 chr12:54324560 NA -0.46 -5.72 -0.33 2.93e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs3814231 0.531 rs17090904 chr10:115476138 C/T cg24846397 chr10:115438155 CASP7 -0.32 -5.26 -0.31 2.96e-7 Vitiligo; CESC cis rs55692411 0.537 rs62262118 chr3:50003586 G/A cg24308560 chr3:49941425 MST1R -0.52 -6.33 -0.36 1.04e-9 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs56235845 0.694 rs11949401 chr5:176765989 A/G cg16006841 chr5:176797999 RGS14 0.46 5.72 0.33 2.81e-8 Hemoglobin concentration;Hematocrit; CESC cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg07697082 chr8:82753677 SNX16 -0.37 -5.84 -0.34 1.48e-8 Diastolic blood pressure; CESC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.52 0.37 3.63e-10 Prudent dietary pattern; CESC cis rs2816062 0.813 rs2816050 chr1:18894432 A/G cg18795169 chr1:18902165 NA -0.94 -19.04 -0.76 1.61e-51 Urate levels in lean individuals; CESC cis rs11677370 0.574 rs11686118 chr2:3854938 C/T cg17052675 chr2:3827356 NA -0.44 -5.53 -0.32 7.7e-8 Type 2 diabetes; CESC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.09 0.3 6.85e-7 Personality dimensions; CESC cis rs2455799 0.613 rs7642876 chr3:15883094 A/G cg16303742 chr3:15540471 COLQ -0.38 -5.74 -0.33 2.62e-8 Mean platelet volume; CESC cis rs4660306 1.000 rs7534467 chr1:45988691 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.72 -0.43 2.33e-13 Homocysteine levels; CESC cis rs34638657 0.732 rs61111557 chr16:82201102 A/C cg09439754 chr16:82129088 HSD17B2 -0.36 -6.24 -0.36 1.71e-9 Lung adenocarcinoma; CESC cis rs1577917 1.000 rs6933377 chr6:86705255 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.43 6.13 0.35 3.22e-9 Response to antipsychotic treatment; CESC cis rs10489202 1.000 rs12404574 chr1:167961235 C/T cg24449463 chr1:168025552 DCAF6 0.46 5.37 0.31 1.73e-7 Schizophrenia; CESC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg16325326 chr1:53192061 ZYG11B -0.7 -11.23 -0.57 3.41e-24 Monocyte count; CESC cis rs7746199 0.736 rs58616630 chr6:27474715 A/G cg18032046 chr6:28092343 ZSCAN16 -0.75 -5.03 -0.3 9.02e-7 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs636291 0.517 rs670666 chr1:10549380 C/T cg07384165 chr1:10488281 NA 0.57 8.34 0.46 4.11e-15 Prostate cancer; CESC cis rs11122272 0.735 rs2256908 chr1:231506557 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.11 0.35 3.49e-9 Hemoglobin concentration; CESC trans rs3942852 0.568 rs6485807 chr11:48102867 G/A cg03929089 chr4:120376271 NA -0.63 -7.78 -0.43 1.64e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs8114671 0.836 rs6120778 chr20:33565169 T/C cg24642439 chr20:33292090 TP53INP2 0.46 5.47 0.32 1.06e-7 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24816464 chr3:86061715 CADM2 0.45 6.46 0.37 5.12e-10 Fibrinogen levels; CESC cis rs34638657 0.732 rs12595971 chr16:82200309 T/C cg09439754 chr16:82129088 HSD17B2 -0.36 -6.28 -0.36 1.37e-9 Lung adenocarcinoma; CESC cis rs9486715 0.838 rs9386473 chr6:96873341 C/A cg06623918 chr6:96969491 KIAA0776 0.78 11.16 0.57 5.91e-24 Headache; CESC cis rs9457247 0.544 rs6920858 chr6:167464630 G/A cg23791538 chr6:167370224 RNASET2 -0.52 -6.87 -0.39 4.45e-11 Crohn's disease; CESC cis rs61524473 1 rs61524473 chr15:45646283 T/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.45e-9 Metabolite levels (small molecules and protein measures); CESC cis rs1355223 0.506 rs11032898 chr11:34870111 C/G cg11622362 chr11:34938112 PDHX;APIP 0.44 5.14 0.3 5.23e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs8027181 0.617 rs11072389 chr15:73088483 C/T cg25632853 chr15:73088954 NA -0.41 -6.32 -0.36 1.11e-9 Triglyceride levels; CESC cis rs763121 0.853 rs5757203 chr22:39044152 G/C cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg01475377 chr6:109611718 NA 0.51 8.43 0.46 2.31e-15 Reticulocyte fraction of red cells; CESC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg14703610 chr5:56206110 C5orf35 -0.42 -5.2 -0.3 4.06e-7 Initial pursuit acceleration; CESC cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg20476274 chr7:133979776 SLC35B4 0.6 8.54 0.46 1.04e-15 Mean platelet volume; CESC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg19622623 chr12:86230825 RASSF9 -0.47 -6.07 -0.35 4.34e-9 Major depressive disorder; CESC cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4523957 0.928 rs216219 chr17:2147291 T/C cg16513277 chr17:2031491 SMG6 0.6 8.27 0.45 6.35e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2243480 1.000 rs34192067 chr7:65887657 C/A cg12463550 chr7:65579703 CRCP 0.71 5.49 0.32 9.37e-8 Diabetic kidney disease; CESC cis rs12973672 1.000 rs28365136 chr19:35769561 T/G cg12095397 chr19:35769544 USF2 0.54 7.35 0.41 2.49e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2180341 0.960 rs9398840 chr6:127669744 G/A cg27446573 chr6:127587934 RNF146 1.06 15.51 0.69 4.62e-39 Breast cancer; CESC cis rs9039 1.000 rs11075212 chr16:9203899 G/A cg08831531 chr16:9218945 NA -0.59 -7.64 -0.42 3.98e-13 Menopause (age at onset); CESC trans rs55704346 0.566 rs13434761 chr4:25388545 T/C cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs752010 0.902 rs28635337 chr1:42101391 G/A cg06885757 chr1:42089581 HIVEP3 0.5 8.2 0.45 1.03e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs8141529 0.702 rs132536 chr22:29302906 A/G cg02153584 chr22:29168773 CCDC117 -0.57 -7.43 -0.42 1.48e-12 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16280683 chr5:61708653 IPO11 0.59 6.45 0.37 5.27e-10 Gut microbiome composition (summer); CESC cis rs642803 1.000 rs557675 chr11:65566719 G/T cg10518572 chr11:65560635 OVOL1 -0.3 -6.47 -0.37 4.74e-10 Urate levels; CESC cis rs10754283 0.967 rs2185195 chr1:90106697 T/C cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs12973672 1.000 rs62109572 chr19:35778919 T/C cg12095397 chr19:35769544 USF2 0.59 7.57 0.42 6.1e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg26314531 chr2:26401878 FAM59B -0.62 -7.07 -0.4 1.37e-11 Gut microbiome composition (summer); CESC cis rs735396 0.627 rs2264778 chr12:121450354 C/A cg15155738 chr12:121454335 C12orf43 0.45 5.23 0.31 3.44e-7 N-glycan levels; CESC cis rs11785400 0.793 rs12546978 chr8:143750205 T/A cg10596483 chr8:143751796 JRK -0.44 -5.3 -0.31 2.41e-7 Schizophrenia; CESC cis rs10791097 0.694 rs7125622 chr11:130743388 T/C cg12179176 chr11:130786555 SNX19 0.65 10.05 0.53 2.42e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1568889 1.000 rs9783281 chr11:28033786 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.74 9.68 0.51 3.52e-19 Bipolar disorder; CESC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg18876405 chr7:65276391 NA 0.5 6.85 0.39 5.04e-11 Aortic root size; CESC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg24642844 chr7:1081250 C7orf50 -0.66 -8.39 -0.46 2.85e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11191205 0.954 rs11191191 chr10:103800979 G/A cg15320455 chr10:103880129 LDB1 0.76 6.63 0.38 1.83e-10 Intelligence (multi-trait analysis); CESC cis rs2115630 0.645 rs4842978 chr15:85197253 T/C cg11189052 chr15:85197271 WDR73 -0.51 -7.02 -0.4 1.84e-11 P wave terminal force; CESC cis rs9905704 0.831 rs12939500 chr17:56848677 T/C cg12560992 chr17:57184187 TRIM37 0.62 7.34 0.41 2.64e-12 Testicular germ cell tumor; CESC cis rs6541297 0.878 rs4846905 chr1:230279582 C/T cg20703242 chr1:230279135 GALNT2 -0.62 -9.66 -0.51 4.25e-19 Coronary artery disease; CESC cis rs3806843 1.000 rs6885319 chr5:140200611 A/C cg26395211 chr5:140044315 WDR55 -0.41 -5.04 -0.3 8.56e-7 Depressive symptoms (multi-trait analysis); CESC cis rs17384381 0.953 rs2284797 chr1:85792383 C/T cg16011679 chr1:85725395 C1orf52 0.79 7.98 0.44 4.35e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs2439831 0.681 rs2444036 chr15:43694108 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.53 0.54 7.06e-22 Lung cancer in ever smokers; CESC cis rs1003719 0.715 rs9980353 chr21:38558812 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.68e-15 Eye color traits; CESC cis rs6598955 0.671 rs12089149 chr1:26638500 C/A cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.31 0.31 2.35e-7 Obesity-related traits; CESC cis rs9914988 0.943 rs11658884 chr17:27132742 A/G cg20469991 chr17:27169893 C17orf63 0.48 5.25 0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs7216064 0.953 rs4791300 chr17:65930772 A/G cg12091567 chr17:66097778 LOC651250 -0.72 -8.23 -0.45 8.28e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg18606378 chr6:57087261 RAB23 -0.53 -6.34 -0.36 1.01e-9 Ulcerative colitis; CESC cis rs710216 0.843 rs710220 chr1:43415346 G/T cg22176566 chr1:43424700 SLC2A1 0.47 5.36 0.31 1.8e-7 Red cell distribution width; CESC cis rs12586317 0.547 rs76770287 chr14:35487210 C/A cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.22e-22 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02685945 chr6:22570146 HDGFL1 -0.73 -7.96 -0.44 5.07e-14 Gut microbiome composition (summer); CESC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg20887711 chr4:1340912 KIAA1530 0.64 8.96 0.48 5.8e-17 Longevity; CESC trans rs10463316 0.894 rs7719630 chr5:150760961 C/T cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs7964748 0.769 rs73179285 chr12:103026921 G/C cg02806658 chr12:102513592 C12orf48;NUP37 -0.57 -5.07 -0.3 7.56e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs62229266 0.804 rs998383 chr21:37445739 C/G cg12218747 chr21:37451666 NA -0.43 -5.94 -0.34 8.83e-9 Mitral valve prolapse; CESC cis rs72627509 0.904 rs3796529 chr4:57797414 C/T cg26694713 chr4:57773883 REST 0.56 5.57 0.32 6.15e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs13242816 1.000 rs7809755 chr7:116110732 C/T cg04696780 chr7:116139425 CAV2 -0.59 -5.28 -0.31 2.65e-7 P wave duration; CESC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.79 13.12 0.63 1.24e-30 Personality dimensions; CESC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.67 0.64 1.54e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs62103177 0.564 rs11874805 chr18:77697110 T/C cg12964065 chr18:77638022 KCNG2 0.5 5.58 0.32 5.9e-8 Opioid sensitivity; CESC cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg16489826 chr6:160211363 TCP1;MRPL18 0.64 7.44 0.42 1.39e-12 Age-related macular degeneration (geographic atrophy); CESC cis rs9303401 0.646 rs7342863 chr17:57227010 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.57 7.4 0.41 1.82e-12 Cognitive test performance; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg21871583 chr3:15374148 SH3BP5 0.51 7.41 0.41 1.65e-12 Breast cancer;Type 2 diabetes; CESC cis rs66573146 0.831 rs56031152 chr4:6973832 C/A cg00086871 chr4:6988644 TBC1D14 1.15 7.48 0.42 1.08e-12 Granulocyte percentage of myeloid white cells; CESC cis rs7726839 0.561 rs11955068 chr5:582324 C/T cg16447950 chr5:562315 NA -0.55 -6.19 -0.36 2.29e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13316255 chr15:75165642 SCAMP2 0.52 6.0 0.35 6.63e-9 Gut microbiome composition (summer); CESC cis rs3011225 0.710 rs3011224 chr1:44318483 C/T cg13606994 chr1:44402422 ARTN -0.35 -5.19 -0.3 4.11e-7 Amyotrophic lateral sclerosis (age of onset); CESC cis rs929354 1.000 rs1182378 chr7:157048322 T/C cg05182265 chr7:156933206 UBE3C 0.43 5.99 0.35 6.69e-9 Body mass index; CESC cis rs9309473 0.948 rs11884776 chr2:73746923 C/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.43 -0.37 5.96e-10 Metabolite levels; CESC cis rs977987 0.806 rs6564252 chr16:75388940 C/T cg03315344 chr16:75512273 CHST6 0.4 5.83 0.34 1.61e-8 Dupuytren's disease; CESC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg23643435 chr2:38893251 GALM -0.66 -9.11 -0.49 2.13e-17 5-HTT brain serotonin transporter levels; CESC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg13607699 chr17:42295918 UBTF 0.63 8.36 0.46 3.49e-15 Total body bone mineral density; CESC cis rs79839061 0.610 rs9994159 chr4:891150 C/T cg07828340 chr4:882639 GAK 1.09 8.63 0.47 5.83e-16 Intelligence (multi-trait analysis); CESC trans rs61931739 0.500 rs11053251 chr12:34520743 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.55 0.42 7.05e-13 Morning vs. evening chronotype; CESC cis rs13242816 1.000 rs56180538 chr7:116079711 C/T cg04696780 chr7:116139425 CAV2 -0.65 -5.7 -0.33 3.2e-8 P wave duration; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24380168 chr7:45040141 CCM2 -0.51 -6.05 -0.35 4.88e-9 Ulcerative colitis; CESC cis rs2180341 0.961 rs7775493 chr6:127615000 C/A cg24812749 chr6:127587940 RNF146 1.06 15.35 0.69 1.74e-38 Breast cancer; CESC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 12.81 0.62 1.48e-29 Alzheimer's disease; CESC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg24818145 chr4:99064322 C4orf37 0.38 5.05 0.3 8.04e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs4795359 chr17:37573146 C/T cg00129232 chr17:37814104 STARD3 -0.56 -7.35 -0.41 2.4e-12 Glomerular filtration rate (creatinine); CESC cis rs2070677 1.000 rs743534 chr10:135349226 G/T cg20169779 chr10:135381914 SYCE1 0.67 7.94 0.44 5.86e-14 Gout; CESC cis rs6500395 0.735 rs7204345 chr16:48666726 T/C cg04672837 chr16:48644449 N4BP1 0.49 6.28 0.36 1.38e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg17366294 chr4:99064904 C4orf37 0.58 8.25 0.45 7.46e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 1.000 rs7267979 chr20:25298087 C/T cg08601574 chr20:25228251 PYGB 0.39 5.52 0.32 8.17e-8 Liver enzyme levels (alkaline phosphatase); CESC trans rs9858542 0.953 rs3811699 chr3:49396360 T/C cg21659725 chr3:3221576 CRBN -0.54 -6.37 -0.36 8.2e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg23754390 chr11:835074 CD151 0.31 5.28 0.31 2.75e-7 Mean platelet volume; CESC cis rs3806843 0.966 rs2563262 chr5:140137712 C/G cg16179182 chr5:140090404 VTRNA1-1 0.38 5.03 0.3 8.99e-7 Depressive symptoms (multi-trait analysis); CESC cis rs4523957 0.890 rs11078024 chr17:2189324 T/C cg16513277 chr17:2031491 SMG6 0.59 8.07 0.44 2.51e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs113835537 0.529 rs11227512 chr11:66281291 T/C cg24851651 chr11:66362959 CCS 0.45 5.55 0.32 6.92e-8 Airway imaging phenotypes; CESC cis rs6582630 0.574 rs12146797 chr12:38436499 T/C cg26384229 chr12:38710491 ALG10B 0.69 10.55 0.54 5.83e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs2933343 0.729 rs6767104 chr3:128648117 G/T cg24203234 chr3:128598194 ACAD9 -0.43 -5.61 -0.33 5.02e-8 IgG glycosylation; CESC cis rs2066819 1.000 rs77853814 chr12:56687572 G/T cg26804944 chr12:56660921 COQ10A -0.81 -5.03 -0.3 8.95e-7 Psoriasis vulgaris; CESC cis rs6736093 1.000 rs6736093 chr2:112655242 C/T cg12686935 chr2:112915763 FBLN7 0.44 5.54 0.32 7.45e-8 Coronary artery disease; CESC cis rs1395 0.778 rs2580759 chr2:27432500 G/T cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.38 -5.24 -0.31 3.24e-7 Blood metabolite levels; CESC cis rs7772486 0.805 rs4896831 chr6:145959481 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.51 0.37 3.71e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs8103278 0.793 rs59093775 chr19:46374037 G/A cg11657440 chr19:46296263 DMWD -0.47 -5.57 -0.32 6.26e-8 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22411068 chr5:10442103 ROPN1L -0.46 -6.62 -0.38 1.98e-10 Gut microbiota (bacterial taxa); CESC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg13918804 chr1:2043761 PRKCZ 0.27 5.12 0.3 5.81e-7 Height; CESC cis rs9818758 0.607 rs73084135 chr3:49272218 A/G cg00383909 chr3:49044727 WDR6 0.91 6.12 0.35 3.28e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs7927592 0.763 rs7119422 chr11:68331154 C/T cg20283391 chr11:68216788 NA 0.44 5.58 0.32 5.86e-8 Total body bone mineral density; CESC cis rs10416265 0.527 rs11084699 chr19:33538393 A/T cg17764715 chr19:33622953 WDR88 0.59 8.13 0.45 1.67e-14 Bone properties (heel); CESC cis rs4853012 0.887 rs2280642 chr2:74358252 T/A cg05890377 chr2:74357713 NA 0.74 9.2 0.49 1.1e-17 Gestational age at birth (maternal effect); CESC cis rs9814567 1.000 rs4974483 chr3:134219001 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.41 -5.66 -0.33 3.91e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6582630 0.623 rs12299293 chr12:38436288 G/A cg26384229 chr12:38710491 ALG10B -0.41 -5.49 -0.32 9.35e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs9467711 0.516 rs523383 chr6:25869848 A/G cg21479132 chr6:26055353 NA 0.58 6.34 0.36 9.83e-10 Autism spectrum disorder or schizophrenia; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg04352962 chr1:209979756 IRF6 0.44 6.17 0.35 2.56e-9 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs2279817 1.000 rs1339801 chr1:18020298 A/G cg21791023 chr1:18019539 ARHGEF10L 0.57 8.35 0.46 3.75e-15 Neuroticism; CESC cis rs16870629 1.000 rs16870629 chr5:1015063 C/T cg00278107 chr5:1061253 SLC12A7 -0.71 -11.4 -0.57 9.16e-25 QT interval; CESC cis rs523522 0.962 rs2233676 chr12:120933607 G/A cg12219531 chr12:120966889 COQ5 0.75 9.99 0.52 3.7e-20 High light scatter reticulocyte count; CESC cis rs2901656 0.934 rs9425311 chr1:172388778 G/T cg03748243 chr1:172413542 C1orf105;PIGC 0.46 6.83 0.39 5.8200000000000003e-11 Red cell distribution width;Platelet distribution width; CESC cis rs72781680 0.752 rs55806536 chr2:23912697 A/G cg08917208 chr2:24149416 ATAD2B 1.14 10.27 0.53 4.72e-21 Lymphocyte counts; CESC cis rs933688 1.000 rs12655973 chr5:90736537 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.14 15.49 0.69 5.83e-39 Smoking behavior; CESC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg12463550 chr7:65579703 CRCP 0.57 7.33 0.41 2.73e-12 Aortic root size; CESC cis rs2519796 0.529 rs2073885 chr9:136814491 T/C cg13751417 chr9:136814406 VAV2 -0.41 -5.21 -0.3 3.88e-7 Hematocrit;Hemoglobin concentration; CESC cis rs11828289 0.660 rs76379912 chr11:23182498 A/G cg20040320 chr11:23191996 NA -0.68 -5.88 -0.34 1.25e-8 Cancer; CESC cis rs2070677 0.935 rs2070676 chr10:135351137 C/G cg20169779 chr10:135381914 SYCE1 0.67 8.1 0.45 1.97e-14 Gout; CESC cis rs4822044 0.617 rs13054514 chr22:42130383 A/G cg03806693 chr22:41940476 POLR3H 0.78 9.54 0.51 9.81e-19 Cannabis dependence symptom count; CESC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg12143784 chr7:64541923 NA 0.4 5.34 0.31 2.03e-7 Calcium levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20990694 chr7:150417431 GIMAP1 0.44 6.2 0.36 2.12e-9 Ulcerative colitis; CESC cis rs748404 0.660 rs548704 chr15:43791706 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.5 0.42 9.94e-13 Lung cancer; CESC cis rs2286503 0.780 rs929464 chr7:22874770 T/C cg11367502 chr7:22862612 TOMM7 0.43 5.58 0.32 5.9e-8 Fibrinogen; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03229959 chr8:38089560 DDHD2 0.52 6.65 0.38 1.64e-10 Gut microbiota (bacterial taxa); CESC cis rs9837602 1.000 rs1021103 chr3:99603230 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 7.42 0.41 1.57e-12 Breast cancer; CESC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs2180341 1.000 rs6937287 chr6:127645719 T/A cg27446573 chr6:127587934 RNF146 1.09 16.35 0.71 5.12e-42 Breast cancer; CESC cis rs2835872 0.758 rs1787399 chr21:39037883 A/G cg06728970 chr21:39037746 KCNJ6 0.3 5.59 0.32 5.72e-8 Electroencephalographic traits in alcoholism; CESC cis rs74925218 1 rs74925218 chr15:78796732 C/T cg24631222 chr15:78858424 CHRNA5 0.63 7.03 0.4 1.8e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg06808227 chr14:105710500 BRF1 -0.6 -7.01 -0.4 1.94e-11 Mean platelet volume;Platelet distribution width; CESC trans rs801193 0.967 rs3800823 chr7:66147110 C/A cg26939375 chr7:64535504 NA -0.62 -8.28 -0.45 6.22e-15 Aortic root size; CESC cis rs806215 0.547 rs59140894 chr7:127430797 C/T cg25922125 chr7:127225783 GCC1 -0.39 -5.06 -0.3 7.93e-7 Type 2 diabetes; CESC cis rs11792861 0.926 rs72607171 chr9:111837776 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 5.18 0.3 4.44e-7 Menarche (age at onset); CESC cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg21573476 chr21:45109991 RRP1B -0.45 -6.15 -0.35 2.83e-9 Mean corpuscular volume; CESC trans rs11992162 0.613 rs6998690 chr8:11798796 A/T cg15556689 chr8:8085844 FLJ10661 0.52 6.48 0.37 4.44e-10 Monocyte count; CESC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.82 -9.22 -0.49 9.78e-18 Gut microbiome composition (summer); CESC cis rs6089584 0.526 rs6061965 chr20:60607858 A/C cg06108461 chr20:60628389 TAF4 -0.58 -7.79 -0.43 1.54e-13 Body mass index; CESC cis rs67478160 0.619 rs1187416 chr14:104311465 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.41 0.54 1.75e-21 Schizophrenia; CESC cis rs8072100 0.582 rs3826536 chr17:45501967 T/A cg25173405 chr17:45401733 C17orf57 -0.43 -5.43 -0.32 1.26e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg22105103 chr4:187893119 NA 0.51 7.61 0.42 4.66e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs8114671 0.836 rs4911461 chr20:33629993 A/C cg24642439 chr20:33292090 TP53INP2 -0.45 -5.44 -0.32 1.19e-7 Height; CESC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.71 0.38 1.2e-10 Prudent dietary pattern; CESC trans rs7246657 0.941 rs7256130 chr19:37933981 T/C cg24637308 chr11:6592297 DNHD1 0.54 6.32 0.36 1.09e-9 Coronary artery calcification; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg14162927 chr1:155145774 TRIM46;KRTCAP2 -0.43 -6.21 -0.36 2.01e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs910316 0.967 rs7146523 chr14:75659880 T/C cg11812906 chr14:75593930 NEK9 -0.84 -13.76 -0.65 6.99e-33 Height; CESC cis rs4888262 0.507 rs9888976 chr16:74580924 C/T cg01733217 chr16:74700730 RFWD3 0.8 11.2 0.57 4.42e-24 Testicular germ cell tumor; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17160590 chr1:222886778 C1orf58;AIDA -0.52 -6.31 -0.36 1.18e-9 Ulcerative colitis; CESC cis rs11532322 1 rs11532322 chr12:123731423 A/G cg05973401 chr12:123451056 ABCB9 0.46 5.51 0.32 8.36e-8 Schizophrenia; CESC cis rs896854 0.902 rs726816 chr8:95968413 T/G cg09323728 chr8:95962352 TP53INP1 -0.42 -9.06 -0.49 3.05e-17 Type 2 diabetes; CESC cis rs9911578 0.967 rs11656413 chr17:57082013 A/C cg12560992 chr17:57184187 TRIM37 -0.99 -17.67 -0.74 1.1e-46 Intelligence (multi-trait analysis); CESC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg00310523 chr12:86230176 RASSF9 0.36 5.71 0.33 3.02e-8 Major depressive disorder; CESC cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.91e-7 Colonoscopy-negative controls vs population controls; CESC cis rs992157 0.710 rs12612347 chr2:219057338 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.66 -9.31 -0.5 5.05e-18 Colorectal cancer; CESC cis rs8070128 0.688 rs59304093 chr17:17875407 A/G cg04398451 chr17:18023971 MYO15A -0.69 -9.51 -0.5 1.19e-18 Total body bone mineral density; CESC trans rs2898290 0.540 rs12677146 chr8:11450737 C/G cg15556689 chr8:8085844 FLJ10661 -0.55 -6.86 -0.39 4.95e-11 Systolic blood pressure; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg13229245 chr11:125366238 FEZ1 0.41 6.1 0.35 3.84e-9 Post-traumatic stress disorder; CESC cis rs2228479 0.702 rs11646374 chr16:89857935 G/A cg14709524 chr16:89940631 TCF25 0.94 7.0 0.39 2.13e-11 Skin colour saturation; CESC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg02427764 chr11:65769310 BANF1;EIF1AD -0.43 -5.06 -0.3 8e-7 Breast cancer; CESC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg21017887 chr14:105400489 NA 0.42 6.75 0.38 9.42e-11 Rheumatoid arthritis; CESC cis rs9388451 0.839 rs1811852 chr6:126071575 G/C cg10911889 chr6:126070802 HEY2 0.41 5.68 0.33 3.6e-8 Brugada syndrome; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04250904 chr19:12623422 ZNF709 -0.48 -6.72 -0.38 1.13e-10 Gut microbiota (bacterial taxa); CESC cis rs28374715 0.532 rs11070328 chr15:41651569 T/C cg20272979 chr15:41787780 ITPKA 0.41 5.06 0.3 7.68e-7 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05210131 chr2:182757482 SSFA2 0.61 6.97 0.39 2.53e-11 Gut microbiome composition (summer); CESC cis rs2290159 0.800 rs59821954 chr3:12687613 T/C cg23032965 chr3:12705835 RAF1 0.51 5.5 0.32 9.11e-8 Cholesterol, total; CESC cis rs7605827 0.930 rs6431705 chr2:15599988 C/G cg19274914 chr2:15703543 NA -0.32 -5.67 -0.33 3.67e-8 Educational attainment (years of education); CESC trans rs2999987 0.506 rs2066416 chr1:72712404 C/T cg00292001 chr3:46853850 NA 0.54 6.03 0.35 5.36e-9 Intelligence (multi-trait analysis); CESC cis rs2645694 0.651 rs2703144 chr4:77830505 C/G cg18351406 chr4:77819688 ANKRD56 0.52 6.28 0.36 1.38e-9 Emphysema distribution in smoking; CESC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg26818010 chr10:134567672 INPP5A -0.88 -10.73 -0.55 1.56e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9814567 0.896 rs4245907 chr3:134347876 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.67 -0.33 3.63e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs898097 0.801 rs68141193 chr17:80878816 C/T cg15664640 chr17:80829946 TBCD -0.66 -9.98 -0.52 4.09e-20 Breast cancer; CESC cis rs72945132 0.882 rs17160753 chr11:70131462 A/G cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs193541 0.632 rs246276 chr5:122239957 G/A cg19412675 chr5:122181750 SNX24 0.49 5.75 0.33 2.47e-8 Glucose homeostasis traits; CESC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg17971929 chr21:40555470 PSMG1 1.01 13.78 0.65 6.34e-33 Cognitive function; CESC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg23161317 chr6:28129485 ZNF389 0.5 6.4 0.37 7.04e-10 Depression; CESC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg18099408 chr3:52552593 STAB1 -0.33 -5.41 -0.32 1.4e-7 Bipolar disorder; CESC trans rs116095464 0.558 rs10055993 chr5:264296 A/C cg00938859 chr5:1591904 SDHAP3 0.7 6.28 0.36 1.35e-9 Breast cancer; CESC cis rs4253772 0.591 rs11703435 chr22:46685563 C/T cg18190219 chr22:46762943 CELSR1 -0.59 -5.46 -0.32 1.09e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9549260 0.599 rs12870023 chr13:41244222 T/A cg21288729 chr13:41239152 FOXO1 0.68 8.46 0.46 1.82e-15 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18281101 chr1:157015843 ARHGEF11 0.54 6.02 0.35 5.85e-9 Gut microbiome composition (summer); CESC cis rs79387448 0.701 rs11465584 chr2:102982629 G/A cg09003973 chr2:102972529 NA 1.19 9.18 0.49 1.27e-17 Gut microbiota (bacterial taxa); CESC cis rs13095912 0.785 rs4686682 chr3:185307402 C/T cg11274856 chr3:185301563 NA 0.39 5.94 0.34 9.09e-9 Systolic blood pressure; CESC cis rs4141404 0.757 rs5749272 chr22:31830351 C/T cg02404636 chr22:31891804 SFI1 -0.4 -5.7 -0.33 3.19e-8 Paclitaxel-induced neuropathy; CESC cis rs9430161 0.611 rs12081197 chr1:11034239 T/C cg27631724 chr1:11040367 C1orf127 0.38 6.21 0.36 2.02e-9 Ewing sarcoma; CESC cis rs11098499 0.955 rs1511015 chr4:120170473 A/C cg24375607 chr4:120327624 NA 0.43 5.22 0.31 3.66e-7 Corneal astigmatism; CESC cis rs1707322 0.717 rs11211161 chr1:46148138 A/C cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs853679 0.607 rs201002 chr6:27808192 A/G cg06606381 chr12:133084897 FBRSL1 -0.73 -7.51 -0.42 9.03e-13 Depression; CESC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.68 -0.33 3.49e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs11696501 0.688 rs2072974 chr20:44313401 G/A cg11783356 chr20:44313418 WFDC10B -0.34 -5.25 -0.31 3.05e-7 Brain structure; CESC trans rs4904167 0.841 rs1599581 chr14:84681620 A/T cg06870609 chr15:89787223 FANCI 0.46 6.06 0.35 4.73e-9 Autism spectrum disorder or schizophrenia; CESC cis rs1215050 0.755 rs1238462 chr4:98850603 A/G cg05340658 chr4:99064831 C4orf37 -0.5 -6.59 -0.38 2.32e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs1008375 0.872 rs2315552 chr4:17627294 A/G cg16339924 chr4:17578868 LAP3 0.57 7.18 0.4 6.9e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs765787 0.530 rs12915027 chr15:45512626 G/A cg24006582 chr15:45444508 DUOX1 0.52 6.32 0.36 1.13e-9 Uric acid levels; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg10515953 chr10:61666281 CCDC6 -0.56 -6.73 -0.38 1.05e-10 Lung cancer in ever smokers; CESC cis rs58785573 0.504 rs9522 chr4:38666972 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.54 7.52 0.42 8.71e-13 Lymphocyte percentage of white cells; CESC cis rs7255436 0.965 rs11666003 chr19:8452102 G/A cg10174797 chr19:8464628 RAB11B 0.39 5.57 0.32 6.11e-8 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11539173 chr22:19843009 GNB1L;C22orf29 0.59 6.52 0.37 3.62e-10 Gut microbiome composition (summer); CESC cis rs11122272 0.766 rs2486732 chr1:231531476 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.6 -8.36 -0.46 3.55e-15 Hemoglobin concentration; CESC cis rs10899021 0.920 rs10899014 chr11:74325109 A/G cg25880958 chr11:74394337 NA -0.74 -7.91 -0.44 7.23e-14 Response to metformin (IC50); CESC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14474793 chr4:39460697 RPL9;LIAS 0.56 6.16 0.35 2.66e-9 Gut microbiome composition (summer); CESC cis rs3806843 0.801 rs801170 chr5:140115343 C/T cg16179182 chr5:140090404 VTRNA1-1 0.38 5.05 0.3 8.28e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6893300 0.785 rs3797762 chr5:179202688 A/G cg14593053 chr5:179126677 CANX -0.49 -5.86 -0.34 1.34e-8 Resting heart rate; CESC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg07870213 chr5:140052090 DND1 -0.58 -6.45 -0.37 5.28e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.76e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11864453 0.647 rs3764314 chr16:72127078 T/C cg16558253 chr16:72132732 DHX38 -0.55 -8.54 -0.46 1.08e-15 Fibrinogen levels; CESC cis rs9682041 0.696 rs10936627 chr3:170104406 C/T cg11886554 chr3:170076028 SKIL 0.7 6.46 0.37 4.94e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs1707322 1.000 rs6695421 chr1:46380207 T/C cg03146154 chr1:46216737 IPP 0.72 9.88 0.52 8.36e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.23 -0.31 3.46e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4835473 0.932 rs13130345 chr4:144842092 C/T cg25736465 chr4:144833511 NA 0.37 5.33 0.31 2.11e-7 Immature fraction of reticulocytes; CESC trans rs2832077 0.527 rs59730679 chr21:30226244 T/C cg14791747 chr16:20752902 THUMPD1 0.53 7.48 0.42 1.12e-12 Cognitive test performance; CESC cis rs34779708 0.931 rs6481935 chr10:35342959 C/T cg03585969 chr10:35415529 CREM 0.77 10.1 0.53 1.63e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs12931792 0.682 rs12373078 chr16:30187676 T/G cg17640201 chr16:30407289 ZNF48 0.6 8.24 0.45 8.18e-15 Tonsillectomy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24448245 chr7:66461718 SBDS;TYW1 0.53 6.72 0.38 1.09e-10 Gut microbiota (bacterial taxa); CESC cis rs6088580 0.634 rs1890002 chr20:32919219 A/G cg24642439 chr20:33292090 TP53INP2 -0.5 -6.59 -0.38 2.42e-10 Glomerular filtration rate (creatinine); CESC cis rs892961 0.899 rs747482 chr17:75412109 T/C cg05865280 chr17:75406074 SEPT9 0.62 12.7 0.62 3.53e-29 Airflow obstruction; CESC cis rs12586317 0.525 rs10144430 chr14:35433682 T/A cg16230307 chr14:35515116 FAM177A1 0.83 10.07 0.53 2.06e-20 Psoriasis; CESC cis rs644799 0.896 rs4430471 chr11:95646774 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.82 12.0 0.59 8.65e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7818688 0.585 rs1031388 chr8:96049684 C/T cg16049864 chr8:95962084 TP53INP1 -0.5 -5.62 -0.33 4.73e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23586394 chr17:8286572 RPL26 -0.47 -6.78 -0.38 7.98e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15729423 chr14:74318413 PTGR2 0.49 6.16 0.35 2.65e-9 Gut microbiota (bacterial taxa); CESC cis rs7216064 0.651 rs12947658 chr17:65903006 A/G cg12091567 chr17:66097778 LOC651250 0.55 6.85 0.39 5.18e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1865721 0.682 rs7242637 chr18:73147492 A/C cg26385618 chr18:73139727 C18orf62 -0.47 -7.52 -0.42 8.61e-13 Intelligence; CESC cis rs7666738 0.606 rs6839946 chr4:99076132 A/C cg17366294 chr4:99064904 C4orf37 0.45 6.04 0.35 5.27e-9 Colonoscopy-negative controls vs population controls; CESC trans rs11637445 0.603 rs1478941 chr15:68127141 A/G cg14583481 chr3:118865028 C3orf30;IGSF11 0.43 6.11 0.35 3.58e-9 Posterior cortical atrophy and Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04935666 chr14:105817407 PACS2 0.43 6.38 0.36 7.93e-10 Fibrinogen levels; CESC cis rs9916302 0.904 rs7221875 chr17:37543328 G/A cg20243544 chr17:37824526 PNMT -0.49 -6.18 -0.35 2.42e-9 Glomerular filtration rate (creatinine); CESC cis rs6667605 0.527 rs12046118 chr1:2540343 A/C cg18854424 chr1:2615690 NA 0.3 5.99 0.35 6.97e-9 Inflammatory bowel disease;Ulcerative colitis; CESC cis rs7474896 0.537 rs1208587 chr10:38207759 A/G cg25427524 chr10:38739819 LOC399744 0.46 5.42 0.32 1.31e-7 Obesity (extreme); CESC cis rs2230307 0.536 rs56215716 chr1:100447486 G/A cg24955406 chr1:100503596 HIAT1 0.53 5.39 0.31 1.56e-7 Carotid intima media thickness; CESC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg08736216 chr1:53307985 ZYG11A -0.4 -7.16 -0.4 7.76e-12 Monocyte count; CESC cis rs1348850 0.789 rs2197611 chr2:178369036 G/C cg23306229 chr2:178417860 TTC30B 0.65 8.07 0.44 2.47e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs561341 1.000 rs72825712 chr17:30316119 A/T cg27661571 chr11:113659931 NA -0.87 -8.06 -0.44 2.57e-14 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.76 10.71 0.55 1.78e-22 Prudent dietary pattern; CESC cis rs708547 0.874 rs1718837 chr4:57871203 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.67 8.77 0.47 2.23e-16 Response to bleomycin (chromatid breaks); CESC cis rs4660306 0.677 rs6429566 chr1:45941852 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -5.29 -0.31 2.57e-7 Homocysteine levels; CESC cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg24829409 chr8:58192753 C8orf71 0.62 7.63 0.42 4.25e-13 Developmental language disorder (linguistic errors); CESC cis rs1448094 0.845 rs11117129 chr12:86349390 A/G cg02569458 chr12:86230093 RASSF9 0.39 5.68 0.33 3.61e-8 Major depressive disorder; CESC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg05368731 chr17:41323189 NBR1 0.54 7.1 0.4 1.13e-11 Menopause (age at onset); CESC cis rs36051895 0.664 rs17425637 chr9:5110000 C/T cg02405213 chr9:5042618 JAK2 -0.52 -6.33 -0.36 1.02e-9 Pediatric autoimmune diseases; CESC cis rs9457247 0.765 rs9459849 chr6:167444160 G/T cg07741184 chr6:167504864 NA 0.35 6.42 0.37 6.25e-10 Crohn's disease; CESC cis rs1461503 0.966 rs11218905 chr11:122840303 A/G cg27398637 chr11:122830231 C11orf63 0.55 8.36 0.46 3.63e-15 Menarche (age at onset); CESC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.35e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10129255 0.957 rs10140904 chr14:107184797 C/T cg23076370 chr14:107095027 NA -0.48 -6.2 -0.36 2.16e-9 Kawasaki disease; CESC cis rs3820928 0.874 rs67513858 chr2:227804819 A/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.66 -0.33 3.83e-8 Pulmonary function; CESC trans rs4665809 0.838 rs6546780 chr2:26352857 T/C cg09258813 chr8:37823409 ADRB3 -0.37 -6.1 -0.35 3.73e-9 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs60843830 1.000 rs62114501 chr2:231741 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.05 0.53 2.44e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg05535760 chr7:792225 HEATR2 -0.79 -8.18 -0.45 1.21e-14 Cerebrospinal P-tau181p levels; CESC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg05132306 chr1:1846340 CALML6 -0.3 -6.37 -0.36 8.33e-10 Body mass index; CESC cis rs734999 0.566 rs10797435 chr1:2534801 G/C cg20673091 chr1:2541236 MMEL1 0.43 7.16 0.4 7.78e-12 Ulcerative colitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20459655 chr2:135675569 CCNT2 0.38 6.19 0.36 2.32e-9 Gambling; CESC cis rs2070488 1.000 rs1002675 chr3:38445226 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 16.26 0.71 1.07e-41 Electrocardiographic conduction measures; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03041742 chr1:43147857 YBX1 0.59 6.01 0.35 6.12e-9 Gut microbiome composition (summer); CESC cis rs10751667 0.666 rs6597967 chr11:950583 G/T cg06064525 chr11:970664 AP2A2 -0.49 -9.81 -0.52 1.42e-19 Alzheimer's disease (late onset); CESC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg22920501 chr2:26401640 FAM59B 0.86 10.01 0.52 3.25e-20 Gut microbiome composition (summer); CESC cis rs13034020 0.522 rs35217978 chr2:61246548 A/G cg18625361 chr2:61244694 PEX13;PUS10 0.66 5.9 0.34 1.13e-8 Hodgkin's lymphoma; CESC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.74 0.64 8.59e-33 Prudent dietary pattern; CESC cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg17366294 chr4:99064904 C4orf37 0.58 8.39 0.46 2.88e-15 Colonoscopy-negative controls vs population controls; CESC cis rs17601876 0.814 rs28674681 chr15:51559917 A/C cg19946085 chr15:51559439 CYP19A1 -0.34 -5.52 -0.32 7.94e-8 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs2046867 0.818 rs17010204 chr3:72879099 G/A cg25664220 chr3:72788482 NA -0.37 -5.36 -0.31 1.82e-7 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs7429990 0.965 rs7642590 chr3:48099750 G/A cg11946769 chr3:48343235 NME6 -0.5 -6.13 -0.35 3.17e-9 Educational attainment (years of education); CESC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg26818010 chr10:134567672 INPP5A -0.9 -10.88 -0.56 4.78e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2439831 1.000 rs689596 chr15:43761717 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.17 0.6 2.26e-27 Lung cancer in ever smokers; CESC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg00149659 chr3:10157352 C3orf10 0.72 9.27 0.49 6.61e-18 Alzheimer's disease; CESC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg22920501 chr2:26401640 FAM59B -0.66 -7.85 -0.43 1.01e-13 Gut microbiome composition (summer); CESC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg11644478 chr21:40555479 PSMG1 -0.82 -12.36 -0.6 5.28e-28 Cognitive function; CESC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg06873352 chr17:61820015 STRADA -0.6 -9.7 -0.51 3.17e-19 Prudent dietary pattern; CESC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg07507251 chr3:52567010 NT5DC2 0.4 7.11 0.4 1.1e-11 Bipolar disorder; CESC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg23978390 chr7:1156363 C7orf50 0.5 6.65 0.38 1.66e-10 Longevity;Endometriosis; CESC cis rs7814319 0.899 rs1878638 chr8:97258719 C/T cg20787634 chr8:97240163 UQCRB -0.58 -7.5 -0.42 9.91e-13 Lung function (FVC); CESC cis rs6499255 0.951 rs60099379 chr16:69582104 A/G cg15192750 chr16:69999425 NA 0.54 6.14 0.35 2.98e-9 IgE levels; CESC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg16325326 chr1:53192061 ZYG11B 0.91 15.9 0.7 2.02e-40 Monocyte count; CESC cis rs7429990 0.965 rs7431572 chr3:48027851 G/T cg11946769 chr3:48343235 NME6 -0.44 -5.38 -0.31 1.65e-7 Educational attainment (years of education); CESC cis rs2204008 0.537 rs28680519 chr12:38502946 C/T cg13010199 chr12:38710504 ALG10B 0.52 6.7 0.38 1.25e-10 Bladder cancer; CESC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg24829409 chr8:58192753 C8orf71 -0.71 -9.63 -0.51 5.28e-19 Developmental language disorder (linguistic errors); CESC cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg05585544 chr11:47624801 NA -0.52 -7.77 -0.43 1.76e-13 Subjective well-being; CESC cis rs933688 1.000 rs2367353 chr5:90686568 G/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.07 14.21 0.66 1.95e-34 Smoking behavior; CESC trans rs4335177 0.671 rs7028638 chr9:109374085 C/G cg12580783 chr12:49362475 WNT10B -0.37 -6.36 -0.36 8.78e-10 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs1506636 1.000 rs615410 chr7:123437765 T/C cg03229431 chr7:123269106 ASB15 0.46 5.95 0.34 8.51e-9 Plateletcrit;Platelet count; CESC cis rs1577917 0.958 rs28442244 chr6:86701236 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.41 5.35 0.31 1.86e-7 Response to antipsychotic treatment; CESC cis rs10811516 0.520 rs4568676 chr9:21184475 C/G cg23029519 chr9:21187344 IFNA4 0.36 5.81 0.34 1.83e-8 Response to mepolizumab in severe asthma; CESC cis rs2380220 0.808 rs2613554 chr6:95916782 C/A cg15832292 chr6:96025679 MANEA -0.65 -5.95 -0.34 8.46e-9 Behavioural disinhibition (generation interaction); CESC cis rs67311347 1.000 rs73080126 chr3:40509153 A/G cg09455208 chr3:40491958 NA 0.5 8.19 0.45 1.15e-14 Renal cell carcinoma; CESC cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.16 0.3 4.84e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7589342 0.929 rs7590652 chr2:106440306 A/G cg16077055 chr2:106428750 NCK2 0.49 6.93 0.39 3.11e-11 Addiction; CESC cis rs300703 0.935 rs10193882 chr2:246301 A/T cg21211680 chr2:198530 NA -0.85 -7.07 -0.4 1.36e-11 Blood protein levels; CESC trans rs2797160 0.651 rs1268066 chr6:126035041 C/T cg05039488 chr6:79577232 IRAK1BP1 0.53 7.17 0.4 7.49e-12 Endometrial cancer; CESC cis rs4642101 0.737 rs9877165 chr3:12828497 C/T cg05775895 chr3:12838266 CAND2 0.35 5.2 0.3 4.04e-7 QRS complex (12-leadsum); CESC cis rs1050631 0.564 rs1785910 chr18:33729871 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.21 0.45 9.72e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs3767633 0.925 rs2499856 chr1:161926637 C/T cg09175582 chr1:161736000 ATF6 -0.8 -7.37 -0.41 2.12e-12 IgG glycosylation; CESC cis rs7592578 1.000 rs7592578 chr2:191439591 T/G cg27211696 chr2:191398769 TMEM194B 0.62 5.6 0.33 5.29e-8 Diastolic blood pressure; CESC cis rs1348850 0.914 rs12693120 chr2:178283288 A/G cg22681709 chr2:178499509 PDE11A -0.43 -6.3 -0.36 1.2e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.28 0.31 2.75e-7 Menopause (age at onset); CESC cis rs10927875 0.632 rs4481843 chr1:16128205 G/A cg18973939 chr1:16164122 FLJ37453 0.37 5.52 0.32 8.2e-8 Dilated cardiomyopathy; CESC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg07507251 chr3:52567010 NT5DC2 0.32 5.61 0.33 5.12e-8 Bipolar disorder; CESC cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg10523679 chr1:76189770 ACADM 0.76 9.99 0.52 3.74e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7937682 0.889 rs578022 chr11:111490552 G/T cg09085632 chr11:111637200 PPP2R1B -0.95 -14.6 -0.67 8.26e-36 Primary sclerosing cholangitis; CESC cis rs1163251 0.623 rs493427 chr1:120207482 A/T cg19096424 chr1:120255104 PHGDH -0.39 -5.05 -0.3 8.35e-7 Blood metabolite levels; CESC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg19163074 chr7:65112434 INTS4L2 0.41 5.18 0.3 4.32e-7 Aortic root size; CESC cis rs5753618 0.583 rs7287267 chr22:31748415 C/T cg13145458 chr22:31556086 RNF185 -0.47 -5.4 -0.31 1.49e-7 Colorectal cancer; CESC cis rs2777491 1.000 rs2730057 chr15:41736275 C/A cg02330683 chr15:41787940 ITPKA 0.47 6.81 0.39 6.36e-11 Ulcerative colitis; CESC cis rs4319547 0.774 rs10773394 chr12:123124778 C/A cg05707623 chr12:122985044 ZCCHC8 -0.48 -5.87 -0.34 1.31e-8 Body mass index; CESC cis rs2073300 0.536 rs6137947 chr20:23414630 C/A cg16736954 chr20:23401023 NAPB 0.78 5.78 0.33 2.05e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7927592 0.626 rs11228279 chr11:68309680 C/T cg01657329 chr11:68192670 LRP5 0.48 6.33 0.36 1.05e-9 Total body bone mineral density; CESC cis rs60154123 0.730 rs588197 chr1:210463515 A/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.45 5.15 0.3 5.11e-7 Coronary artery disease; CESC cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg11366901 chr6:160182831 ACAT2 0.77 9.41 0.5 2.45e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg26335602 chr6:28129616 ZNF389 0.49 6.82 0.39 6.23e-11 Depression; CESC cis rs7819412 0.775 rs11773990 chr8:10935082 T/C cg21775007 chr8:11205619 TDH -0.37 -5.05 -0.3 8.14e-7 Triglycerides; CESC cis rs116095464 0.558 rs62347683 chr5:230331 C/T cg10591111 chr5:226296 SDHA -0.54 -6.65 -0.38 1.72e-10 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg19916409 chr4:103266691 SLC39A8 -0.42 -6.6 -0.38 2.24e-10 Gambling; CESC cis rs1847202 1.000 rs11918615 chr3:72942407 T/C cg25664220 chr3:72788482 NA -0.34 -5.08 -0.3 7.05e-7 Motion sickness; CESC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg11247378 chr22:39784982 NA -0.5 -7.85 -0.43 1.02e-13 Intelligence (multi-trait analysis); CESC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg18876405 chr7:65276391 NA 0.69 9.61 0.51 5.83e-19 Aortic root size; CESC cis rs8114671 0.836 rs2425006 chr20:33571228 T/G cg06115741 chr20:33292138 TP53INP2 -0.44 -5.24 -0.31 3.22e-7 Height; CESC cis rs11785400 0.793 rs35985277 chr8:143736137 C/T cg24634471 chr8:143751801 JRK 0.46 5.84 0.34 1.52e-8 Schizophrenia; CESC cis rs3015497 0.789 rs8003372 chr14:51102351 G/A cg09863266 chr14:51125203 SAV1 -0.34 -5.35 -0.31 1.89e-7 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00287636 chr16:49892218 NA 0.49 6.16 0.35 2.69e-9 Gut microbiome composition (summer); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg07508260 chr11:111742291 ALG9 -0.46 -7.03 -0.4 1.76e-11 Vertical cup-disc ratio; CESC cis rs1372520 0.873 rs2583990 chr4:90771499 A/G cg15133208 chr4:90757351 SNCA -0.39 -5.61 -0.33 5.06e-8 Neuroticism; CESC cis rs2637266 0.549 rs10824433 chr10:78412843 T/C cg18941641 chr10:78392320 NA -0.32 -5.18 -0.3 4.34e-7 Pulmonary function; CESC cis rs868036 0.645 rs4776987 chr15:68123915 A/T cg24579218 chr15:68104479 NA 0.37 5.08 0.3 7.14e-7 Restless legs syndrome; CESC cis rs7662987 0.517 rs1311618 chr4:100012612 A/G cg13256891 chr4:100009986 ADH5 0.74 7.97 0.44 4.75e-14 Smoking initiation; CESC cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg19077165 chr18:44547161 KATNAL2 -0.58 -8.56 -0.47 9.18e-16 Personality dimensions; CESC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg24829409 chr8:58192753 C8orf71 -0.67 -8.14 -0.45 1.54e-14 Developmental language disorder (linguistic errors); CESC cis rs8044868 0.530 rs9924964 chr16:72085561 T/A cg16558253 chr16:72132732 DHX38 -0.39 -6.08 -0.35 4.15e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg17372223 chr3:52568218 NT5DC2 0.43 6.39 0.37 7.25e-10 Bipolar disorder; CESC trans rs7615952 0.611 rs7632305 chr3:125634767 C/T cg07211511 chr3:129823064 LOC729375 -0.89 -8.15 -0.45 1.47e-14 Blood pressure (smoking interaction); CESC cis rs6894249 0.874 rs11745587 chr5:131796922 A/G cg00255919 chr5:131827918 IRF1 -0.34 -5.55 -0.32 6.9e-8 Asthma; CESC cis rs8103278 1.000 rs8109951 chr19:46289503 C/T cg14061069 chr19:46274453 DMPK -0.37 -5.16 -0.3 4.94e-7 Coronary artery disease; CESC cis rs2836950 0.772 rs62222988 chr21:40569508 T/C cg11644478 chr21:40555479 PSMG1 -0.52 -6.42 -0.37 6.17e-10 Menarche (age at onset); CESC cis rs7296418 0.675 rs1879379 chr12:123727443 G/A cg05973401 chr12:123451056 ABCB9 0.49 6.32 0.36 1.08e-9 Platelet count; CESC cis rs9467711 0.659 rs35433030 chr6:26529890 G/A cg14345882 chr6:26364793 BTN3A2 0.61 5.24 0.31 3.27e-7 Autism spectrum disorder or schizophrenia; CESC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.43 5.88 0.34 1.26e-8 Lymphocyte counts; CESC cis rs4077515 0.870 rs11793497 chr9:139271850 A/G cg14169450 chr9:139327907 INPP5E 0.37 5.4 0.31 1.47e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg09165964 chr15:75287851 SCAMP5 0.52 6.9 0.39 3.72e-11 Breast cancer; CESC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.55 0.47 9.74e-16 Menopause (age at onset); CESC cis rs4950928 0.823 rs10920579 chr1:203158972 A/G cg14085262 chr1:203155938 CHI3L1 -0.5 -5.2 -0.3 3.9e-7 YKL-40 levels; CESC cis rs1348850 0.645 rs11887886 chr2:178425730 C/T cg23306229 chr2:178417860 TTC30B 0.83 9.07 0.49 2.73e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9393777 0.623 rs9358946 chr6:26478927 G/A cg12826209 chr6:26865740 GUSBL1 0.65 6.85 0.39 5.16e-11 Intelligence (multi-trait analysis); CESC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg24829409 chr8:58192753 C8orf71 -0.67 -7.97 -0.44 4.6e-14 Developmental language disorder (linguistic errors); CESC cis rs123509 0.913 rs339686 chr3:42769688 T/C cg12982090 chr3:42733453 KBTBD5 0.7 8.4 0.46 2.67e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9815354 0.761 rs17280777 chr3:41806167 C/T cg03022575 chr3:42003672 ULK4 0.7 6.18 0.35 2.42e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25910647 chr15:62539093 NA 0.46 6.42 0.37 6.21e-10 Fibrinogen levels; CESC cis rs11122272 0.701 rs7414807 chr1:231476874 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.43 -5.73 -0.33 2.7e-8 Hemoglobin concentration; CESC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg00149659 chr3:10157352 C3orf10 0.77 9.66 0.51 4.22e-19 Alzheimer's disease; CESC cis rs9814567 1.000 rs1534025 chr3:134313304 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.47 6.28 0.36 1.41e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs11098499 0.863 rs1383532 chr4:120434404 A/T cg09307838 chr4:120376055 NA -0.9 -12.45 -0.61 2.44e-28 Corneal astigmatism; CESC cis rs9611519 0.780 rs9611527 chr22:41644428 G/A cg03806693 chr22:41940476 POLR3H -0.69 -7.73 -0.43 2.21e-13 Neuroticism; CESC trans rs10489896 0.541 rs16843220 chr1:234589999 T/C cg23817893 chr11:86085932 CCDC81 -0.45 -6.2 -0.36 2.14e-9 Cognitive test performance; CESC cis rs9300255 0.544 rs10772995 chr12:123671761 T/C cg05973401 chr12:123451056 ABCB9 0.49 5.49 0.32 9.51e-8 Neutrophil percentage of white cells; CESC cis rs73411413 0.661 rs11599981 chr11:1520063 C/T cg18133074 chr11:1473084 BRSK2 -0.37 -5.07 -0.3 7.4e-7 Myringotomy; CESC cis rs7830933 1.000 rs7830933 chr8:23603324 A/G cg04349084 chr8:23602677 NA 0.43 5.28 0.31 2.65e-7 Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist-to-hip ratio adjusted for body mass index;Waist circumference adjusted for body mass index;Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI in non-smokers; CESC cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.24 0.31 3.23e-7 Colonoscopy-negative controls vs population controls; CESC cis rs939658 0.805 rs35230534 chr15:79441093 T/C cg17916960 chr15:79447300 NA -0.35 -5.98 -0.34 7.25e-9 Refractive error; CESC cis rs2273669 0.667 rs12198088 chr6:109338433 C/T cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs10504229 0.861 rs67966192 chr8:58188172 A/C cg05313129 chr8:58192883 C8orf71 -0.46 -5.7 -0.33 3.26e-8 Developmental language disorder (linguistic errors); CESC cis rs533581 0.816 rs1559446 chr16:88975332 A/G cg16701003 chr16:89028210 CBFA2T3 0.56 7.87 0.44 9.31e-14 Social autistic-like traits; CESC cis rs644799 0.965 rs602512 chr11:95561682 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.24 0.66 1.53e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg00166722 chr3:10149974 C3orf24 0.52 6.61 0.38 2.15e-10 Alzheimer's disease; CESC cis rs2439831 0.850 rs3825783 chr15:44102309 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.67 0.43 3.2e-13 Lung cancer in ever smokers; CESC cis rs4268898 0.722 rs2288072 chr2:24390517 G/A cg06627628 chr2:24431161 ITSN2 0.54 6.95 0.39 2.81e-11 Asthma; CESC cis rs9640161 0.789 rs66688634 chr7:150053806 G/A cg17279839 chr7:150038598 RARRES2 0.46 5.52 0.32 8.03e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.8 0.39 6.78e-11 Bipolar disorder; CESC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg22800045 chr5:56110881 MAP3K1 0.82 10.18 0.53 9.04e-21 Initial pursuit acceleration; CESC cis rs2629540 0.847 rs10901807 chr10:126384610 G/A cg08799069 chr10:126477246 METTL10 0.58 7.22 0.41 5.49e-12 Cocaine dependence; CESC trans rs66573146 0.831 rs67702333 chr4:6983040 C/G cg07817883 chr1:32538562 TMEM39B 1.27 8.51 0.46 1.34e-15 Granulocyte percentage of myeloid white cells; CESC cis rs72627123 0.867 rs77320708 chr14:74478482 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.63 0.33 4.49e-8 Morning vs. evening chronotype; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00390735 chr8:143553436 BAI1 -0.41 -6.02 -0.35 5.74e-9 Gambling; CESC cis rs3026101 0.671 rs9789002 chr17:5298792 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs11577318 0.853 rs4333841 chr1:26631927 T/C cg19743891 chr1:26644573 UBXN11;CD52 -0.28 -5.11 -0.3 6.05e-7 Granulocyte percentage of myeloid white cells; CESC cis rs6938 0.618 rs12901190 chr15:75231452 T/C cg17294928 chr15:75287854 SCAMP5 0.51 6.65 0.38 1.66e-10 Breast cancer; CESC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.63 0.38 1.84e-10 Bipolar disorder; CESC cis rs6866344 0.697 rs56159071 chr5:178127246 T/A cg03877680 chr5:178157825 ZNF354A 0.75 8.5 0.46 1.36e-15 Neutrophil percentage of white cells; CESC cis rs887829 0.569 rs3806596 chr2:234637707 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.49 6.53 0.37 3.35e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs2120019 0.608 rs4886414 chr15:75308650 C/T cg09165964 chr15:75287851 SCAMP5 0.94 16.41 0.71 3.03e-42 Blood trace element (Zn levels); CESC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg18758796 chr5:131593413 PDLIM4 0.41 5.53 0.32 7.5e-8 Acylcarnitine levels; CESC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg17724175 chr1:150552817 MCL1 0.39 6.02 0.35 5.81e-9 Melanoma; CESC cis rs8077577 0.747 rs7405677 chr17:18131236 C/T cg16794390 chr17:18148240 FLII -0.44 -6.26 -0.36 1.54e-9 Obesity-related traits; CESC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg26314531 chr2:26401878 FAM59B -0.59 -6.67 -0.38 1.5e-10 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.5 0.54 8.86e-22 Prudent dietary pattern; CESC cis rs2708240 0.905 rs2538984 chr7:147581460 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.55 -0.32 7.07e-8 QT interval (drug interaction); CESC cis rs6964587 0.626 rs6972945 chr7:91549576 C/G cg17063962 chr7:91808500 NA -0.46 -6.36 -0.36 9.03e-10 Breast cancer; CESC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg16006841 chr5:176797999 RGS14 0.43 5.17 0.3 4.68e-7 Hemoglobin concentration;Hematocrit; CESC cis rs3015497 0.603 rs61476576 chr14:51021765 G/A cg26011998 chr14:51135199 SAV1 0.47 5.36 0.31 1.8e-7 Mean platelet volume; CESC cis rs250677 0.798 rs11168080 chr5:148409821 C/T cg18129178 chr5:148520854 ABLIM3 -0.52 -5.54 -0.32 7.29e-8 Breast cancer; CESC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs4654899 0.758 rs35913932 chr1:21423025 G/T cg05370193 chr1:21551575 ECE1 0.36 5.44 0.32 1.23e-7 Superior frontal gyrus grey matter volume; CESC cis rs7945705 0.935 rs10769971 chr11:8925276 C/T cg12365402 chr11:9010492 NRIP3 0.4 6.09 0.35 3.86e-9 Hemoglobin concentration; CESC cis rs7385804 0.727 rs221790 chr7:100278282 G/C cg20848291 chr7:100343083 ZAN 0.56 7.57 0.42 6.06e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs7208859 0.623 rs383436 chr17:28959179 A/G cg14008862 chr17:28927542 LRRC37B2 0.75 5.5 0.32 9.05e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs72781680 0.611 rs72783625 chr2:24315540 C/T cg20701182 chr2:24300061 SF3B14 0.92 10.55 0.54 6.09e-22 Lymphocyte counts; CESC cis rs62045849 0.557 rs6500534 chr16:89190313 C/T cg26950739 chr16:89183275 ACSF3 0.56 5.06 0.3 7.98e-7 Red blood cell count; CESC cis rs524281 0.861 rs11607393 chr11:65875149 C/A cg14036092 chr11:66035641 RAB1B -0.62 -6.29 -0.36 1.27e-9 Electroencephalogram traits; CESC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg23281280 chr6:28129359 ZNF389 0.6 8.0 0.44 3.86e-14 Depression; CESC cis rs854765 0.647 rs854770 chr17:18019048 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.27 0.45 6.76e-15 Total body bone mineral density; CESC cis rs6460942 0.556 rs10228123 chr7:12374025 A/C cg02935154 chr7:12443704 VWDE -0.39 -5.16 -0.3 4.78e-7 Coronary artery disease; CESC cis rs2439831 0.867 rs2251844 chr15:43836478 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.72 9.26 0.49 7.22e-18 Lung cancer in ever smokers; CESC cis rs524023 0.874 rs495130 chr11:64449307 C/T cg07220939 chr11:64358617 SLC22A12 -0.35 -5.42 -0.32 1.35e-7 Urate levels in obese individuals; CESC cis rs9549367 0.789 rs34989271 chr13:113894766 G/A cg00898013 chr13:113819073 PROZ -0.51 -6.98 -0.39 2.43e-11 Platelet distribution width; CESC cis rs4919694 1.000 rs4917382 chr10:104838510 G/A cg04362960 chr10:104952993 NT5C2 0.78 6.93 0.39 3.25e-11 Arsenic metabolism; CESC cis rs9303542 0.559 rs12603976 chr17:46617163 C/A cg04904318 chr17:46607828 HOXB1 -0.58 -5.67 -0.33 3.64e-8 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs9309473 0.687 rs6706409 chr2:73606508 G/T cg20560298 chr2:73613845 ALMS1 0.46 6.39 0.37 7.5e-10 Metabolite levels; CESC cis rs7692995 1.000 rs34683079 chr4:17939302 T/C cg08925142 chr4:18023851 LCORL -0.45 -5.28 -0.31 2.65e-7 Height; CESC cis rs1775715 0.707 rs2808079 chr10:32167385 C/T cg18675610 chr10:32216311 ARHGAP12 0.35 5.46 0.32 1.07e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs12449000 1 rs12449000 chr16:89872970 T/C cg03388025 chr16:89894329 SPIRE2 0.42 8.18 0.45 1.21e-14 Schizophrenia; CESC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg04518342 chr5:131593106 PDLIM4 0.41 6.25 0.36 1.59e-9 Breast cancer; CESC cis rs7084402 0.967 rs1346302 chr10:60267137 G/A cg07615347 chr10:60278583 BICC1 -0.59 -9.0 -0.48 4.4e-17 Refractive error; CESC cis rs826838 1.000 rs11183160 chr12:38676702 T/C cg26384229 chr12:38710491 ALG10B 0.84 14.9 0.68 7.16e-37 Heart rate; CESC cis rs1062177 0.756 rs2915826 chr5:151119963 G/A cg12924095 chr5:151150029 G3BP1 -0.43 -5.34 -0.31 2e-7 Preschool internalizing problems; CESC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs599083 0.530 rs689179 chr11:68179166 A/G cg16797656 chr11:68205561 LRP5 -0.38 -5.09 -0.3 6.79e-7 Bone mineral density (spine); CESC cis rs1387259 0.759 rs7960122 chr12:48777000 C/T cg04545296 chr12:48745243 ZNF641 -0.38 -6.39 -0.37 7.54e-10 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs2274273 0.905 rs4652 chr14:55605036 A/C cg04306507 chr14:55594613 LGALS3 0.29 5.79 0.34 1.96e-8 Protein biomarker; CESC cis rs58785573 0.570 rs1824652 chr4:38644597 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.49 6.92 0.39 3.48e-11 Lymphocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15345415 chr5:151150903 G3BP1 0.53 6.2 0.36 2.12e-9 Gut microbiome composition (summer); CESC cis rs6088580 0.567 rs6088520 chr20:33132364 A/G cg24642439 chr20:33292090 TP53INP2 -0.47 -6.04 -0.35 5.18e-9 Glomerular filtration rate (creatinine); CESC cis rs6426558 0.515 rs7521110 chr1:227384459 T/A cg10327440 chr1:227177885 CDC42BPA -0.47 -5.85 -0.34 1.48e-8 Neutrophil percentage of white cells; CESC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg19592336 chr6:28129416 ZNF389 0.58 7.71 0.43 2.54e-13 Depression; CESC cis rs910316 1.000 rs10142626 chr14:75555636 A/T cg11812906 chr14:75593930 NEK9 0.91 15.5 0.69 5.27e-39 Height; CESC cis rs17253792 0.822 rs78386830 chr14:56069224 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs9309473 1.000 rs2421555 chr2:73816955 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.5 -0.37 4e-10 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25635913 chr19:4497977 HDGF2 -0.58 -6.51 -0.37 3.85e-10 Gut microbiome composition (summer); CESC cis rs17209837 0.607 rs45478299 chr7:87111321 G/A cg00919237 chr7:87102261 ABCB4 -0.49 -6.5 -0.37 4.02e-10 Gallbladder cancer; CESC cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg15017067 chr4:17643749 FAM184B 0.38 5.35 0.31 1.86e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg04317338 chr11:64019027 PLCB3 0.9 9.42 0.5 2.3e-18 Mean platelet volume; CESC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg22105103 chr4:187893119 NA 0.46 6.66 0.38 1.61e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6032067 0.538 rs62206431 chr20:43737073 G/A cg10761708 chr20:43804764 PI3 0.46 5.15 0.3 5.05e-7 Blood protein levels; CESC cis rs28489187 0.706 rs233131 chr1:85795259 G/A cg16011679 chr1:85725395 C1orf52 0.47 5.6 0.33 5.46e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs7799006 0.634 rs34502289 chr7:2311266 G/A cg12745145 chr7:2261452 MAD1L1 -0.35 -5.4 -0.31 1.5e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs10426930 0.607 rs858423 chr19:5048374 T/C cg18473234 chr19:5097819 KDM4B -0.52 -5.08 -0.3 7.3e-7 Monocyte percentage of white cells; CESC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg16049864 chr8:95962084 TP53INP1 -0.7 -12.91 -0.62 6.44e-30 Type 2 diabetes; CESC cis rs3106136 0.527 rs2664894 chr4:95153831 T/C cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Capecitabine sensitivity; CESC cis rs7507204 0.530 rs4807469 chr19:3443382 G/C cg08380311 chr19:3435252 NFIC 0.8 11.98 0.59 1.01e-26 Height; CESC trans rs3780486 0.505 rs7868663 chr9:33141229 A/G cg04842962 chr6:43655489 MRPS18A 0.71 11.11 0.56 8.44e-24 IgG glycosylation; CESC trans rs60180747 1.000 rs17851970 chr15:66612965 C/T cg01218494 chr17:71160864 SSTR2 -0.45 -6.08 -0.35 4.19e-9 Testicular germ cell tumor; CESC cis rs6141600 0.506 rs2590990 chr20:34671179 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.02 -0.35 5.94e-9 Height;Hip circumference; CESC cis rs6121246 0.512 rs45443696 chr20:30311396 A/C cg13852791 chr20:30311386 BCL2L1 0.86 11.26 0.57 2.66e-24 Mean corpuscular hemoglobin; CESC cis rs3820068 0.580 rs7556473 chr1:15996858 C/T cg13390004 chr1:15929781 NA -0.34 -5.1 -0.3 6.44e-7 Systolic blood pressure; CESC cis rs9486715 1.000 rs11153082 chr6:97059666 A/G cg06623918 chr6:96969491 KIAA0776 -0.92 -13.79 -0.65 5.63e-33 Headache; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16492828 chr12:100567203 GOLGA2L1 -0.71 -7.61 -0.42 4.95e-13 Gut microbiome composition (summer); CESC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.56 0.58 2.73e-25 Alzheimer's disease; CESC cis rs79349575 0.715 rs55724082 chr17:47017879 G/A cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.45e-10 Type 2 diabetes; CESC cis rs9660992 0.649 rs12128254 chr1:205268097 C/T cg00857998 chr1:205179979 DSTYK 0.48 5.33 0.31 2.15e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs6912958 0.500 rs9342104 chr6:87798512 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.39 -5.78 -0.33 2.09e-8 Monocyte percentage of white cells; CESC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg08470875 chr2:26401718 FAM59B -0.75 -7.79 -0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs3820928 0.874 rs10933163 chr2:227815286 A/G cg11843606 chr2:227700838 RHBDD1 -0.43 -5.66 -0.33 3.91e-8 Pulmonary function; CESC cis rs2816062 0.760 rs2745319 chr1:18895078 G/A cg18795169 chr1:18902165 NA -0.94 -19.04 -0.76 1.61e-51 Urate levels in lean individuals; CESC cis rs7726839 0.540 rs7558 chr5:660491 C/T cg16447950 chr5:562315 NA -0.61 -6.66 -0.38 1.56e-10 Obesity-related traits; CESC cis rs17253792 0.822 rs2147114 chr14:56077118 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.09e-10 Bipolar disorder; CESC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg12193833 chr17:30244370 NA -0.71 -7.31 -0.41 3.09e-12 Hip circumference adjusted for BMI; CESC cis rs17376456 0.825 rs35496867 chr5:93220400 T/C cg21475434 chr5:93447410 FAM172A 0.81 7.07 0.4 1.38e-11 Diabetic retinopathy; CESC cis rs11677416 1.000 rs6542090 chr2:113524795 T/C cg27083787 chr2:113543245 IL1A 0.41 5.16 0.3 4.75e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs7772486 0.869 rs2777473 chr6:146301494 G/A cg23711669 chr6:146136114 FBXO30 0.75 10.71 0.55 1.72e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs2559856 0.904 rs2695283 chr12:102089391 G/C cg12213457 chr12:102090980 CHPT1 -0.37 -5.48 -0.32 9.79e-8 Blood protein levels; CESC cis rs4664293 0.967 rs1346325 chr2:160542506 C/T cg08347373 chr2:160653686 CD302 -0.33 -5.39 -0.31 1.55e-7 Monocyte percentage of white cells; CESC cis rs4919694 0.901 rs79331374 chr10:104882913 G/A cg04362960 chr10:104952993 NT5C2 0.8 6.81 0.39 6.36e-11 Arsenic metabolism; CESC cis rs2404602 0.735 rs4886495 chr15:76738959 C/T cg23625390 chr15:77176239 SCAPER 0.44 6.08 0.35 4.07e-9 Blood metabolite levels; CESC cis rs7312933 0.703 rs11181378 chr12:42600658 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.51 0.37 3.8e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7520050 0.778 rs2088102 chr1:46032974 T/C cg24296786 chr1:45957014 TESK2 0.5 6.29 0.36 1.29e-9 Red blood cell count;Reticulocyte count; CESC cis rs35955747 0.902 rs131209 chr22:31732461 A/G cg25791279 chr22:32026902 PISD 0.48 5.86 0.34 1.4e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs7666738 0.830 rs7696686 chr4:98938445 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.04 -0.44 3e-14 Personality dimensions; CESC cis rs6754311 0.689 rs191079 chr2:136633771 T/C cg07169764 chr2:136633963 MCM6 0.69 8.32 0.45 4.8e-15 Mosquito bite size; CESC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg12463550 chr7:65579703 CRCP -0.46 -5.94 -0.34 8.81e-9 Aortic root size; CESC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.71 -8.13 -0.45 1.65e-14 Gut microbiome composition (summer); CESC cis rs17253792 0.822 rs7150841 chr14:56088986 T/C cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14235685 chr19:44096461 IRGQ 0.43 6.45 0.37 5.33e-10 Fibrinogen levels; CESC cis rs2109514 0.840 rs13223362 chr7:116137006 G/A cg12739419 chr7:116140593 CAV2 -0.38 -6.84 -0.39 5.51e-11 Prevalent atrial fibrillation; CESC cis rs7216064 1.000 rs59950564 chr17:65860859 A/G cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.79e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs35110281 0.811 rs7275705 chr21:45056453 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 7.11 0.4 1.1e-11 Mean corpuscular volume; CESC cis rs2996428 0.709 rs12127399 chr1:3721609 G/A cg22529645 chr1:3704559 LRRC47 0.39 5.03 0.3 9.13e-7 Red cell distribution width; CESC cis rs7666738 0.753 rs13122897 chr4:98936185 C/A cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs12618769 0.652 rs3769701 chr2:99195111 A/C cg10123293 chr2:99228465 UNC50 0.41 5.31 0.31 2.32e-7 Bipolar disorder; CESC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg15052019 chr19:19431593 KIAA0892;SF4 -0.41 -5.2 -0.3 3.93e-7 Tonsillectomy; CESC cis rs7091068 0.671 rs1764322 chr10:95406276 T/G cg20715218 chr10:95462985 C10orf4 -0.54 -5.85 -0.34 1.42e-8 Urinary tract infection frequency; CESC cis rs2635047 0.638 rs2668760 chr18:44682891 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.32 5.03 0.3 9.22e-7 Educational attainment; CESC cis rs7537052 0.646 rs6680302 chr1:36653540 C/T cg24686825 chr1:36642396 MAP7D1 -0.6 -9.1 -0.49 2.24e-17 Schizophrenia; CESC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg00933542 chr6:150070202 PCMT1 0.3 5.11 0.3 6.15e-7 Lung cancer; CESC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg16325326 chr1:53192061 ZYG11B 0.82 12.7 0.62 3.43e-29 Monocyte count; CESC cis rs17023223 0.537 rs12092807 chr1:119750644 A/G cg05756136 chr1:119680316 WARS2 0.48 5.03 0.3 9.19e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs9611565 0.918 rs4820438 chr22:41767135 C/T cg06634786 chr22:41940651 POLR3H -0.57 -6.04 -0.35 5.24e-9 Vitiligo; CESC cis rs9549260 0.755 rs4943797 chr13:41201633 A/G cg21288729 chr13:41239152 FOXO1 -0.66 -8.64 -0.47 5.24e-16 Red blood cell count; CESC cis rs3768617 0.706 rs8179460 chr1:183056222 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.03 0.52 2.82e-20 Fuchs's corneal dystrophy; CESC cis rs13102973 0.899 rs10212820 chr4:135899842 G/T cg14419869 chr4:135874104 NA -0.34 -5.18 -0.3 4.49e-7 Subjective well-being; CESC cis rs9858542 0.953 rs11710037 chr3:49675334 C/G cg07274523 chr3:49395745 GPX1 0.68 8.59 0.47 7.34e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs854765 0.520 rs9899355 chr17:17898243 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.52 7.19 0.4 6.47e-12 Total body bone mineral density; CESC cis rs3106136 0.546 rs183993 chr4:95130025 G/A cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.24 -0.57 3.07e-24 Capecitabine sensitivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02856952 chr12:111885521 SH2B3 -0.59 -6.42 -0.37 6.12e-10 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.53 0.54 6.83e-22 Height; CESC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg20126647 chr17:40714003 COASY 0.49 6.62 0.38 1.96e-10 Colorectal or endometrial cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25789511 chr20:60757919 GTPBP5 0.61 7.64 0.42 3.96e-13 Gut microbiome composition (summer); CESC cis rs4835473 0.932 rs34950821 chr4:144659327 G/A cg25736465 chr4:144833511 NA -0.32 -5.16 -0.3 4.85e-7 Immature fraction of reticulocytes; CESC cis rs116095464 0.558 rs10055354 chr5:243794 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.27 0.31 2.9e-7 Breast cancer; CESC cis rs909002 0.800 rs2176807 chr1:32092735 T/G cg13919466 chr1:32135498 COL16A1 -0.46 -8.3 -0.45 5.27e-15 Intelligence (multi-trait analysis); CESC cis rs9929218 1.000 rs13339591 chr16:68809273 T/C cg02972257 chr16:68554789 NA 0.43 5.12 0.3 5.89e-7 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10301338 chr18:24129315 KCTD1 -0.59 -6.48 -0.37 4.54e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07353731 chr12:123341735 HIP1R 0.56 7.81 0.43 1.37e-13 Fibrinogen levels; CESC cis rs6840258 1.000 rs55787557 chr4:87950825 A/G cg08197287 chr4:87952173 AFF1 -0.4 -5.37 -0.31 1.7e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs7044106 0.791 rs735109 chr9:123488879 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.57 0.32 6.27e-8 Hip circumference adjusted for BMI; CESC trans rs8073060 0.586 rs225294 chr17:33925762 G/A cg19694781 chr19:47549865 TMEM160 -0.72 -6.95 -0.39 2.85e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs1322639 0.614 rs9294967 chr6:169565406 C/T cg03254818 chr6:169586852 NA -0.51 -5.81 -0.34 1.75e-8 Pulse pressure; CESC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg22549504 chr19:17448937 GTPBP3 0.5 5.54 0.32 7.3e-8 Systemic lupus erythematosus; CESC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg19163074 chr7:65112434 INTS4L2 0.41 5.21 0.3 3.76e-7 Aortic root size; CESC cis rs965469 1.000 rs8123289 chr20:3253831 T/C cg25506879 chr20:3388711 C20orf194 -0.59 -6.07 -0.35 4.52e-9 IFN-related cytopenia; CESC cis rs7503807 0.967 rs7215486 chr17:78612034 C/T cg09596252 chr17:78655493 RPTOR 0.47 6.86 0.39 4.73e-11 Obesity; CESC cis rs1707322 1.000 rs11211235 chr1:46440375 G/A cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg05861140 chr6:150128134 PCMT1 -0.38 -5.52 -0.32 7.97e-8 Lung cancer; CESC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg09263875 chr16:632152 PIGQ 0.67 11.6 0.58 1.95e-25 Height; CESC cis rs10883723 0.810 rs10786671 chr10:104271303 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.58 0.42 5.73e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs3026101 0.671 rs72634032 chr17:5303437 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.39e-8 Body mass index; CESC cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg09035930 chr12:129282057 SLC15A4 0.69 9.2 0.49 1.1e-17 Systemic lupus erythematosus; CESC cis rs17293817 0.589 rs2387654 chr10:1419953 C/T cg04271617 chr10:1416546 ADARB2 0.36 5.73 0.33 2.8e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9814567 1.000 rs62271513 chr3:134298412 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.02 0.35 5.85e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs8044868 0.606 rs7189591 chr16:72099011 G/T cg01557791 chr16:72042693 DHODH -0.43 -5.89 -0.34 1.17e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg24250549 chr1:154909240 PMVK 0.72 10.85 0.55 6.34e-23 Prostate cancer; CESC cis rs362272 0.545 rs2749785 chr4:3325179 G/C cg08886695 chr4:3369023 RGS12 -0.41 -5.52 -0.32 8.04e-8 Serum sulfate level; CESC cis rs10791097 0.748 rs2282579 chr11:130735482 C/T cg12179176 chr11:130786555 SNX19 0.63 9.66 0.51 4.17e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7267979 1.000 rs10966 chr20:25282944 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 18.59 0.75 6.14e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs4957048 0.541 rs12519390 chr5:676546 A/G cg16447950 chr5:562315 NA -0.66 -6.55 -0.37 3e-10 Ulcerative colitis; CESC trans rs9929218 1.000 rs28450087 chr16:68803726 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.21 -0.45 9.51e-15 Colorectal cancer; CESC cis rs34779708 0.733 rs4298846 chr10:35547380 A/G cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs7586879 0.558 rs6718510 chr2:25122323 A/C cg01884057 chr2:25150051 NA 0.38 7.42 0.41 1.56e-12 Body mass index; CESC cis rs7000551 0.751 rs1116085 chr8:22394920 A/G cg12081754 chr8:22256438 SLC39A14 0.44 5.84 0.34 1.56e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC trans rs1814175 0.817 rs11493756 chr11:50017885 T/C cg03929089 chr4:120376271 NA -0.94 -15.59 -0.69 2.56e-39 Height; CESC cis rs2929278 0.617 rs2955969 chr15:44114527 G/A cg02155558 chr15:43621948 ADAL;LCMT2 -0.47 -7.25 -0.41 4.44e-12 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06536150 chr1:2458209 PANK4 -0.47 -6.06 -0.35 4.54e-9 Ulcerative colitis; CESC cis rs2404602 0.610 rs28823285 chr15:77050395 T/C cg23625390 chr15:77176239 SCAPER -0.47 -6.52 -0.37 3.54e-10 Blood metabolite levels; CESC cis rs2361718 1.000 rs2361718 chr17:78103466 C/T cg06718696 chr17:78121285 EIF4A3 0.46 6.21 0.36 2.05e-9 Yeast infection; CESC cis rs858239 0.600 rs7776649 chr7:23119317 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.68 0.43 3.08e-13 Cerebrospinal fluid biomarker levels; CESC cis rs36051895 0.664 rs10815157 chr9:5108771 C/G cg02405213 chr9:5042618 JAK2 -0.5 -6.29 -0.36 1.28e-9 Pediatric autoimmune diseases; CESC cis rs6662572 0.737 rs7532388 chr1:46472734 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.07 0.3 7.55e-7 Blood protein levels; CESC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg12419862 chr22:24373484 LOC391322 -0.72 -10.05 -0.53 2.51e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg04369109 chr6:150039330 LATS1 -0.41 -5.54 -0.32 7.11e-8 Lung cancer; CESC cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg10018233 chr7:150070692 REPIN1 0.43 6.98 0.39 2.42e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.72 10.5 0.54 8.51e-22 Hip circumference adjusted for BMI; CESC cis rs7072216 0.763 rs2274244 chr10:100175218 A/G cg26618903 chr10:100175079 PYROXD2 -0.38 -5.85 -0.34 1.41e-8 Metabolite levels; CESC cis rs710216 0.917 rs900836 chr1:43412727 T/C cg07803811 chr1:43423981 SLC2A1 -0.5 -5.47 -0.32 1.02e-7 Red cell distribution width; CESC cis rs72945132 0.882 rs12278125 chr11:70134016 T/C cg14191688 chr11:70257035 CTTN 0.41 5.19 0.3 4.24e-7 Coronary artery disease; CESC cis rs1005277 0.505 rs200910 chr10:38108176 C/T cg25427524 chr10:38739819 LOC399744 -0.67 -10.06 -0.53 2.28e-20 Extrinsic epigenetic age acceleration; CESC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg21782813 chr7:2030301 MAD1L1 0.5 7.25 0.41 4.48e-12 Bipolar disorder and schizophrenia; CESC cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg00701064 chr4:6280414 WFS1 0.68 11.71 0.58 8.68e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2735413 0.918 rs7190752 chr16:78077430 T/C cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs7098414 0.530 rs4146515 chr10:82116602 G/A cg00277334 chr10:82204260 NA -0.53 -7.95 -0.44 5.57e-14 Post bronchodilator FEV1; CESC cis rs7580658 0.895 rs62157549 chr2:128066007 A/G cg10021288 chr2:128175891 PROC -0.41 -6.59 -0.38 2.34e-10 Protein C levels; CESC cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg05340658 chr4:99064831 C4orf37 0.75 10.74 0.55 1.42e-22 Colonoscopy-negative controls vs population controls; CESC cis rs2559856 1.000 rs2559855 chr12:102090080 A/G cg15068132 chr12:102092402 CHPT1 0.43 6.21 0.36 2e-9 Blood protein levels; CESC cis rs3772130 0.540 rs57791671 chr3:121608433 T/A cg20356878 chr3:121714668 ILDR1 0.42 6.12 0.35 3.37e-9 Cognitive performance; CESC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg05872129 chr22:39784769 NA 0.78 10.1 0.53 1.66e-20 Intelligence (multi-trait analysis); CESC cis rs9913156 0.793 rs72835633 chr17:4562643 C/T cg00122941 chr17:4613640 ARRB2 0.85 9.99 0.52 3.79e-20 Lymphocyte counts; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg14737592 chr12:57914238 DDIT3 -0.48 -6.27 -0.36 1.45e-9 Height; CESC cis rs1568889 1.000 rs16917687 chr11:28062614 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.83 0.55 7.35e-23 Bipolar disorder; CESC cis rs3743266 0.507 rs9630426 chr15:60739053 C/T cg22293140 chr15:60689852 ANXA2 -0.72 -7.58 -0.42 5.76e-13 Menarche (age at onset); CESC cis rs3026101 0.671 rs56344067 chr17:5316459 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.41 5.27 0.31 2.82e-7 Body mass index; CESC cis rs34779708 0.733 rs4102764 chr10:35545392 T/C cg03585969 chr10:35415529 CREM 0.55 6.14 0.35 3.04e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs854765 0.693 rs12941039 chr17:17765655 C/T cg16928487 chr17:17741425 SREBF1 0.62 11.33 0.57 1.61e-24 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16280946 chr22:20716554 NA -0.67 -7.94 -0.44 5.74e-14 Gut microbiome composition (summer); CESC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg06481639 chr22:41940642 POLR3H 0.55 6.07 0.35 4.3e-9 Vitiligo; CESC cis rs9399135 0.933 rs7755680 chr6:135294259 A/G cg24558204 chr6:135376177 HBS1L 0.5 6.75 0.38 9.09e-11 Red blood cell count; CESC cis rs977987 0.800 rs1011121 chr16:75325933 A/G cg03315344 chr16:75512273 CHST6 0.37 5.34 0.31 2e-7 Dupuytren's disease; CESC cis rs561341 1.000 rs8069199 chr17:30281845 A/G cg19193384 chr17:30244184 NA -0.61 -6.41 -0.37 6.51e-10 Hip circumference adjusted for BMI; CESC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg23281280 chr6:28129359 ZNF389 0.39 5.76 0.33 2.31e-8 Cardiac Troponin-T levels; CESC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg21970626 chr13:21893289 NA -0.44 -5.04 -0.3 8.54e-7 White matter hyperintensity burden; CESC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg22920501 chr2:26401640 FAM59B 0.53 6.6 0.38 2.24e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs6120849 0.754 rs6120793 chr20:33604407 T/C cg24642439 chr20:33292090 TP53INP2 0.67 6.62 0.38 1.94e-10 Protein C levels; CESC cis rs9488822 0.676 rs12202181 chr6:116327102 A/G cg05304507 chr6:116381966 FRK 0.26 6.56 0.37 2.86e-10 Cholesterol, total;LDL cholesterol; CESC cis rs6141600 0.760 rs2746103 chr20:34703934 T/G cg07747181 chr20:34652970 NA -0.38 -5.16 -0.3 4.75e-7 Height;Hip circumference; CESC cis rs3820928 0.934 rs66959645 chr2:227761582 C/A cg05526886 chr2:227700861 RHBDD1 -0.42 -5.37 -0.31 1.69e-7 Pulmonary function; CESC cis rs524281 0.861 rs10791854 chr11:65963543 A/T cg14036092 chr11:66035641 RAB1B -0.59 -6.15 -0.35 2.84e-9 Electroencephalogram traits; CESC cis rs477692 0.648 rs10829599 chr10:131321881 C/T cg24747557 chr10:131355152 MGMT -0.38 -5.26 -0.31 2.95e-7 Response to temozolomide; CESC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg06221963 chr1:154839813 KCNN3 -0.7 -12.26 -0.6 1.16e-27 Prostate cancer; CESC cis rs6063312 0.518 rs6122718 chr20:47346225 A/G cg18078177 chr20:47281410 PREX1 -0.6 -7.59 -0.42 5.47e-13 Tonometry; CESC cis rs12681366 0.708 rs2930958 chr8:95440553 A/G cg13257157 chr8:95487014 RAD54B 0.38 5.19 0.3 4.26e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs7208859 0.673 rs9898858 chr17:29156211 A/T cg13385521 chr17:29058706 SUZ12P 0.75 6.0 0.35 6.29e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2204008 0.743 rs2127952 chr12:37995364 G/T cg26384229 chr12:38710491 ALG10B 0.66 9.47 0.5 1.58e-18 Bladder cancer; CESC cis rs9815354 0.556 rs55953604 chr3:42004428 A/G cg03022575 chr3:42003672 ULK4 0.64 5.83 0.34 1.62e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs3820068 0.603 rs6660234 chr1:15962590 T/C cg13390004 chr1:15929781 NA 0.37 5.89 0.34 1.18e-8 Systolic blood pressure; CESC cis rs17641971 0.684 rs11990854 chr8:49992048 T/C cg00325661 chr8:49890786 NA 0.39 5.5 0.32 8.94e-8 Blood metabolite levels; CESC cis rs8114671 0.933 rs6087683 chr20:33774444 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.18 0.3 4.41e-7 Height; CESC cis rs17376456 1.000 rs13174700 chr5:93554644 G/A cg25358565 chr5:93447407 FAM172A 1.21 11.29 0.57 2.11e-24 Diabetic retinopathy; CESC cis rs2204008 0.869 rs34438288 chr12:38211582 G/T cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs7264396 0.676 rs6060723 chr20:34549947 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.23 -0.53 6.44e-21 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18888595 chr8:92082609 OTUD6B -0.65 -7.36 -0.41 2.26e-12 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12730826 chr1:205179972 DSTYK -0.43 -6.25 -0.36 1.62e-9 Gambling; CESC cis rs1005277 0.522 rs289643 chr10:37941494 T/G cg25427524 chr10:38739819 LOC399744 -0.62 -8.82 -0.48 1.57e-16 Extrinsic epigenetic age acceleration; CESC cis rs3747547 0.581 rs72726097 chr9:38135087 C/T cg13774184 chr9:37916125 SHB -0.62 -5.11 -0.3 6.23e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg22862634 chr11:62369728 EML3;MTA2 0.59 7.95 0.44 5.33e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7089973 0.668 rs10885622 chr10:116643844 C/T cg25233709 chr10:116636983 FAM160B1 0.38 6.03 0.35 5.53e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs11608355 0.545 rs11615949 chr12:109894347 G/A cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg21144161 chr5:423903 AHRR 0.36 5.86 0.34 1.35e-8 Cystic fibrosis severity; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22046830 chr8:145133508 EXOSC4 -0.45 -6.48 -0.37 4.41e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1348850 0.634 rs2293471 chr2:178487729 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.5 5.54 0.32 7.32e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25944898 chr11:64085532 PRDX5;TRMT112 -0.49 -6.7 -0.38 1.27e-10 Fibrinogen levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13195218 chr1:223900468 CAPN2 -0.48 -6.01 -0.35 6.25e-9 Ulcerative colitis; CESC cis rs727505 1.000 rs727505 chr7:124462081 C/T cg23710748 chr7:124431027 NA -0.46 -7.18 -0.4 7.09e-12 Lewy body disease; CESC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg08859206 chr1:53392774 SCP2 -0.57 -7.8 -0.43 1.39e-13 Monocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12893361 chr12:122124854 NA -0.46 -6.35 -0.36 9.24e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04203298 chr11:59521722 STX3 -0.46 -6.26 -0.36 1.55e-9 Ulcerative colitis; CESC cis rs910316 0.763 rs735452 chr14:75497984 A/G cg11812906 chr14:75593930 NEK9 -0.81 -12.9 -0.62 7.16e-30 Height; CESC cis rs79976124 0.797 rs79522358 chr6:66641140 C/G cg07460842 chr6:66804631 NA 0.71 8.33 0.46 4.36e-15 Type 2 diabetes; CESC cis rs798766 1.000 rs11729657 chr4:1737585 T/C cg05874882 chr4:1763078 NA -0.58 -8.12 -0.45 1.8e-14 Bladder cancer;Urinary bladder cancer; CESC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg07677032 chr17:61819896 STRADA 0.45 5.96 0.34 8.19e-9 Prudent dietary pattern; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg11429632 chr9:123964581 RAB14 -0.56 -7.35 -0.41 2.44e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6546550 0.901 rs7573442 chr2:70154037 G/A cg02498382 chr2:70120550 SNRNP27 -0.4 -6.95 -0.39 2.78e-11 Prevalent atrial fibrillation; CESC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg18758796 chr5:131593413 PDLIM4 -0.43 -5.8 -0.34 1.85e-8 Acylcarnitine levels; CESC cis rs10979 1.000 rs1054752 chr6:143890097 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs17253792 0.822 rs12323476 chr14:56172722 C/T cg01858014 chr14:56050164 KTN1 0.59 5.45 0.32 1.14e-7 Putamen volume; CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg09177884 chr7:1199841 ZFAND2A -0.57 -6.38 -0.36 8.04e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg18876405 chr7:65276391 NA 0.57 7.64 0.42 4.04e-13 Aortic root size; CESC cis rs1005277 0.502 rs2800484 chr10:38542415 C/T cg00409905 chr10:38381863 ZNF37A -0.51 -6.84 -0.39 5.62e-11 Extrinsic epigenetic age acceleration; CESC cis rs11638352 0.661 rs2615286 chr15:44417068 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.58 -5.48 -0.32 1e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg12564285 chr5:131593104 PDLIM4 0.4 6.18 0.35 2.46e-9 Breast cancer; CESC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg23978390 chr7:1156363 C7orf50 0.58 5.84 0.34 1.52e-8 Bronchopulmonary dysplasia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23649784 chr1:156105746 LMNA 0.47 6.2 0.36 2.12e-9 Fibrinogen levels; CESC cis rs561341 0.714 rs473535 chr17:30312365 A/G cg12193833 chr17:30244370 NA -0.67 -6.16 -0.35 2.71e-9 Hip circumference adjusted for BMI; CESC cis rs9287719 0.601 rs6755281 chr2:10769855 T/C cg00105475 chr2:10696890 NA 0.37 5.04 0.3 8.5e-7 Prostate cancer; CESC cis rs17826219 0.500 rs9891256 chr17:29072692 C/T cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02333352 chr5:1076627 SLC12A7 -0.53 -6.35 -0.36 9.36e-10 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg22920501 chr2:26401640 FAM59B 0.91 10.38 0.54 2.08e-21 Gut microbiome composition (summer); CESC cis rs4450131 0.522 rs3781463 chr10:126337190 C/T cg20435097 chr10:126320824 FAM53B 0.3 5.29 0.31 2.5e-7 White blood cell count (basophil); CESC cis rs12476592 0.571 rs1446565 chr2:63731575 T/C cg17519650 chr2:63277830 OTX1 -0.47 -5.4 -0.31 1.46e-7 Childhood ear infection; CESC cis rs1577917 1.000 rs10944170 chr6:86685469 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.92 -0.34 9.76e-9 Response to antipsychotic treatment; CESC cis rs710216 0.718 rs841851 chr1:43401829 A/G cg03128534 chr1:43423976 SLC2A1 0.44 5.13 0.3 5.73e-7 Red cell distribution width; CESC cis rs763121 0.819 rs138700 chr22:39129999 A/G cg06544989 chr22:39130855 UNC84B 0.48 8.68 0.47 4.1e-16 Menopause (age at onset); CESC cis rs4975616 0.839 rs2447853 chr5:1333077 A/G cg06550200 chr5:1325588 CLPTM1L -0.68 -10.62 -0.55 3.57e-22 Lung cancer; CESC trans rs7786808 0.579 rs4045391 chr7:158181826 T/C cg03441993 chr4:55093323 NA 0.41 6.36 0.36 9.01e-10 Obesity-related traits; CESC cis rs2228479 0.850 rs34033205 chr16:89922959 G/T cg14709524 chr16:89940631 TCF25 0.87 6.12 0.35 3.27e-9 Skin colour saturation; CESC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.02 0.56 1.63e-23 Alzheimer's disease; CESC cis rs9929218 0.551 rs6499193 chr16:68727069 C/T cg01251360 chr16:68772225 CDH1 -0.23 -5.14 -0.3 5.35e-7 Colorectal cancer; CESC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.89 0.39 4e-11 Bipolar disorder; CESC cis rs9625935 0.536 rs9608819 chr22:30260809 A/C cg01021169 chr22:30184971 ASCC2 0.41 6.43 0.37 5.79e-10 Tonsillectomy; CESC cis rs6964587 0.839 rs62466159 chr7:91450507 A/G cg17063962 chr7:91808500 NA 0.5 6.39 0.37 7.42e-10 Breast cancer; CESC trans rs6054906 0.710 rs6117744 chr20:7265038 A/C cg18229107 chr14:64854676 MTHFD1 0.46 6.13 0.35 3.09e-9 Response to amphetamines; CESC cis rs67311347 1.000 rs73078158 chr3:40472567 G/C cg09455208 chr3:40491958 NA 0.49 8.09 0.45 2.1e-14 Renal cell carcinoma; CESC cis rs4979906 1.000 rs11002247 chr10:79446901 T/C cg07817648 chr10:79422355 NA -0.47 -5.53 -0.32 7.61e-8 Mortality in heart failure; CESC cis rs888194 0.686 rs11067376 chr12:110027795 A/G cg05360138 chr12:110035743 NA 0.39 5.1 0.3 6.63e-7 Neuroticism; CESC cis rs9291683 0.530 rs73227883 chr4:9979279 T/C cg11266682 chr4:10021025 SLC2A9 0.62 12.7 0.62 3.45e-29 Bone mineral density; CESC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.45e-28 Prudent dietary pattern; CESC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7208859 0.623 rs8075163 chr17:29106310 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs858239 0.863 rs274058 chr7:23391509 C/G cg23682824 chr7:23144976 KLHL7 0.39 5.23 0.31 3.48e-7 Cerebrospinal fluid biomarker levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07277190 chr12:48723631 H1FNT 0.47 6.25 0.36 1.63e-9 Fibrinogen levels; CESC cis rs7904368 0.806 rs6602161 chr10:16862280 A/G cg14835575 chr10:16859367 RSU1 0.53 5.61 0.33 5.16e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs2933343 0.729 rs813945 chr3:128660937 A/G cg25356066 chr3:128598488 ACAD9 0.59 8.39 0.46 2.87e-15 IgG glycosylation; CESC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg19717773 chr7:2847554 GNA12 -0.58 -8.43 -0.46 2.24e-15 Height; CESC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.83 0.34 1.64e-8 Menopause (age at onset); CESC cis rs6500602 0.627 rs2270363 chr16:4526292 A/G cg08645402 chr16:4508243 NA 0.43 6.03 0.35 5.41e-9 Schizophrenia; CESC cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg24296786 chr1:45957014 TESK2 0.63 8.16 0.45 1.37e-14 High light scatter reticulocyte count; CESC cis rs2073300 1.000 rs12625160 chr20:23442008 T/C cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02629833 chr17:80349836 NA -0.56 -6.94 -0.39 3e-11 Gut microbiome composition (summer); CESC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg05132306 chr1:1846340 CALML6 -0.3 -6.3 -0.36 1.26e-9 Body mass index; CESC cis rs11785693 0.862 rs6995565 chr8:4990461 C/T cg26367366 chr8:4980734 NA -0.56 -5.14 -0.3 5.3e-7 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs4704187 0.663 rs1477935 chr5:74448494 C/T cg03227963 chr5:74354835 NA 0.3 5.5 0.32 8.75e-8 Response to amphetamines; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24005309 chr10:1095235 IDI1 0.57 6.04 0.35 5.25e-9 Gut microbiome composition (summer); CESC cis rs3020736 0.500 rs6002597 chr22:42488160 C/A cg15557168 chr22:42548783 NA 0.45 6.18 0.35 2.46e-9 Autism spectrum disorder or schizophrenia; CESC cis rs6500395 1.000 rs8059819 chr16:48682834 A/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.29 -0.36 1.29e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs708547 1.000 rs2412770 chr4:57794660 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.7 7.87 0.44 8.82e-14 Response to bleomycin (chromatid breaks); CESC cis rs2832191 0.679 rs2705659 chr21:30363908 G/C cg24692254 chr21:30365293 RNF160 1.02 18.29 0.75 6.82e-49 Dental caries; CESC trans rs2727020 0.930 rs1164686 chr11:49291822 C/T cg15704280 chr7:45808275 SEPT13 0.8 11.17 0.57 5.5e-24 Coronary artery disease; CESC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg03709012 chr19:19516395 GATAD2A 0.89 12.55 0.61 1.19e-28 Tonsillectomy; CESC trans rs61931739 0.857 rs1828514 chr12:34139600 A/G cg26384229 chr12:38710491 ALG10B 0.44 6.07 0.35 4.4e-9 Morning vs. evening chronotype; CESC cis rs4728302 0.838 rs2042453 chr7:133580730 G/A cg10665199 chr7:133106180 EXOC4 0.4 5.48 0.32 9.86e-8 Intelligence;Intelligence (multi-trait analysis); CESC trans rs10242455 0.702 rs74416635 chr7:99180569 G/A cg09045935 chr12:6379348 NA 0.93 7.66 0.43 3.53e-13 Blood metabolite levels; CESC cis rs3960554 0.808 rs867973 chr7:75686007 G/A cg17325771 chr7:75508891 RHBDD2 -0.36 -5.24 -0.31 3.25e-7 Eotaxin levels; CESC cis rs454510 0.542 rs10754417 chr1:120177454 G/T cg16322792 chr1:120165303 ZNF697 0.35 5.82 0.34 1.71e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs7917772 0.503 rs2031602 chr10:104307955 G/C ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.38 0.31 1.64e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs11098499 0.820 rs12503082 chr4:120284317 A/G cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs433852 0.718 rs386551 chr19:49138286 C/G cg06530960 chr19:49140787 SEC1;DBP -0.42 -5.13 -0.3 5.72e-7 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; CESC cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg09658497 chr7:2847517 GNA12 -0.36 -5.33 -0.31 2.1e-7 Height; CESC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.17e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12477438 0.765 rs7607578 chr2:99669771 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs1865721 0.804 rs719179 chr18:73146396 A/G cg26385618 chr18:73139727 C18orf62 -0.53 -8.32 -0.46 4.61e-15 Intelligence; CESC cis rs4566357 0.615 rs3769643 chr2:227917270 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.15 -0.4 8.33e-12 Coronary artery disease; CESC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg08027265 chr7:2291960 NA -0.43 -6.45 -0.37 5.18e-10 Schizophrenia; CESC cis rs1023500 0.505 rs134874 chr22:42661144 A/G cg15557168 chr22:42548783 NA -0.42 -6.33 -0.36 1.04e-9 Schizophrenia; CESC cis rs3754214 0.857 rs488271 chr1:150284534 A/G cg09579323 chr1:150459698 TARS2 -0.46 -6.03 -0.35 5.58e-9 Cerebrospinal fluid biomarker levels; CESC cis rs2425143 1.000 rs55761608 chr20:34344226 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -7.89 -0.44 8.21e-14 Blood protein levels; CESC cis rs6964587 0.839 rs6949700 chr7:91467435 A/G cg17063962 chr7:91808500 NA 0.5 6.64 0.38 1.75e-10 Breast cancer; CESC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg19468946 chr17:37922297 IKZF3 -0.39 -5.11 -0.3 6.24e-7 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19940975 chr18:32820997 ZNF397 0.56 6.2 0.36 2.17e-9 Gut microbiome composition (summer); CESC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg21770322 chr7:97807741 LMTK2 0.59 8.76 0.47 2.37e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs3806843 1.000 rs2240692 chr5:140183585 A/G cg26395211 chr5:140044315 WDR55 -0.42 -5.33 -0.31 2.07e-7 Depressive symptoms (multi-trait analysis); CESC cis rs950776 0.714 rs615470 chr15:78885988 T/C cg06917634 chr15:78832804 PSMA4 -0.51 -6.14 -0.35 3.07e-9 Sudden cardiac arrest; CESC cis rs9908102 0.740 rs56266951 chr17:12905139 G/A cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs10861342 0.892 rs11112366 chr12:105486108 G/A cg23923672 chr12:105501055 KIAA1033 0.71 5.31 0.31 2.29e-7 IgG glycosylation; CESC cis rs6060717 0.536 rs7271036 chr20:34467215 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.76 6.93 0.39 3.22e-11 Hip circumference adjusted for BMI; CESC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg17372223 chr3:52568218 NT5DC2 0.43 6.47 0.37 4.6e-10 Bipolar disorder; CESC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg00310523 chr12:86230176 RASSF9 0.34 5.38 0.31 1.65e-7 Major depressive disorder; CESC cis rs4253772 0.938 rs41427746 chr22:46637239 T/C cg00784671 chr22:46762841 CELSR1 -0.48 -5.86 -0.34 1.39e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9863 0.828 rs7135314 chr12:124478566 A/T cg17562584 chr12:124393655 DNAH10 0.29 5.03 0.3 9.21e-7 White blood cell count; CESC trans rs9371601 1.000 rs9371601 chr6:152790573 A/C cg22268271 chr22:39548261 CBX7 -0.46 -6.56 -0.37 2.82e-10 Bipolar disorder;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg02891314 chr5:179741120 GFPT2 -0.71 -9.84 -0.52 1.09e-19 Height; CESC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg22920501 chr2:26401640 FAM59B -0.82 -9.6 -0.51 6.25e-19 Gut microbiome composition (summer); CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg23602909 chr7:157956050 PTPRN2 -0.54 -9.42 -0.5 2.33e-18 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg20476274 chr7:133979776 SLC35B4 -0.42 -5.57 -0.32 6.16e-8 Mean platelet volume; CESC cis rs4722585 0.533 rs2158359 chr7:26193309 A/C cg07876897 chr7:26191696 NFE2L3 -0.42 -5.52 -0.32 8.13e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); CESC cis rs116095464 0.558 rs6869925 chr5:264036 A/G cg20965017 chr5:231967 SDHA -0.48 -5.43 -0.32 1.25e-7 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27539858 chr16:29367194 RUNDC2C 0.47 6.48 0.37 4.54e-10 Fibrinogen levels; CESC cis rs763014 0.966 rs7198877 chr16:661439 A/G cg09263875 chr16:632152 PIGQ 0.66 11.27 0.57 2.5e-24 Height; CESC cis rs3820928 0.874 rs10167086 chr2:227792729 A/T cg11843606 chr2:227700838 RHBDD1 0.43 5.7 0.33 3.11e-8 Pulmonary function; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg18993626 chr8:74463939 STAU2 0.48 7.57 0.42 6.07e-13 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1048238 0.605 rs1889785 chr1:16348729 G/A cg22431228 chr1:16359049 CLCNKA -0.49 -9.43 -0.5 2.18e-18 Systolic blood pressure; CESC cis rs2075371 0.932 rs34664116 chr7:133984878 G/A cg20476274 chr7:133979776 SLC35B4 0.63 9.0 0.48 4.56e-17 Mean platelet volume; CESC cis rs9915657 0.715 rs9906100 chr17:70095365 C/T cg09344028 chr17:70110421 NA 0.44 8.67 0.47 4.44e-16 Thyroid hormone levels; CESC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg03609598 chr5:56110824 MAP3K1 -0.54 -5.69 -0.33 3.42e-8 Initial pursuit acceleration; CESC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.93 9.08 0.49 2.65e-17 Platelet count; CESC cis rs7647973 1.000 rs13322887 chr3:49555583 G/A cg07636037 chr3:49044803 WDR6 -0.72 -10.34 -0.54 2.85e-21 Menarche (age at onset); CESC cis rs9487051 0.676 rs7773213 chr6:109601885 C/T cg01475377 chr6:109611718 NA -0.45 -7.1 -0.4 1.13e-11 Reticulocyte fraction of red cells; CESC cis rs4523957 0.928 rs4790321 chr17:2173499 C/T cg16513277 chr17:2031491 SMG6 -0.59 -7.99 -0.44 4.21e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7605827 0.930 rs1019360 chr2:15524741 C/T cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs10504073 0.669 rs341809 chr8:50042557 C/T cg00325661 chr8:49890786 NA 0.49 7.16 0.4 8.18e-12 Blood metabolite ratios; CESC cis rs7107174 1.000 rs11603112 chr11:78073491 G/A cg02023728 chr11:77925099 USP35 0.38 5.39 0.31 1.57e-7 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg05340658 chr4:99064831 C4orf37 0.83 12.74 0.62 2.5e-29 Colonoscopy-negative controls vs population controls; CESC cis rs425277 0.958 rs262687 chr1:2117155 G/A cg04315214 chr1:2043799 PRKCZ -0.38 -5.26 -0.31 3.02e-7 Height; CESC cis rs1506636 0.720 rs2456552 chr7:123441400 A/G cg03229431 chr7:123269106 ASB15 0.41 5.71 0.33 2.98e-8 Plateletcrit;Platelet count; CESC cis rs11122272 0.735 rs2749707 chr1:231527316 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs8067354 0.574 rs2526353 chr17:57988607 G/T cg02344993 chr17:57696989 CLTC 0.53 5.48 0.32 9.75e-8 Hemoglobin concentration; CESC trans rs459571 0.606 rs457420 chr9:136909261 A/G cg10765909 chr12:53715428 AAAS 0.46 6.02 0.35 5.88e-9 Platelet distribution width; CESC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg17366294 chr4:99064904 C4orf37 0.58 7.76 0.43 1.85e-13 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs561341 0.556 rs542244 chr17:30307242 T/C cg19193384 chr17:30244184 NA -0.67 -6.34 -0.36 9.81e-10 Hip circumference adjusted for BMI; CESC cis rs6547741 0.935 rs4665384 chr2:27848397 A/G cg21248554 chr2:27665150 KRTCAP3 0.25 5.2 0.3 4.02e-7 Oral cavity cancer; CESC cis rs936229 0.861 rs7162232 chr15:75115895 G/A cg14664628 chr15:75095509 CSK -1.0 -16.33 -0.71 6.1e-42 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs17826219 0.561 rs11655876 chr17:29017150 G/A cg14008862 chr17:28927542 LRRC37B2 0.6 5.23 0.31 3.41e-7 Body mass index; CESC cis rs8002861 0.846 rs12867732 chr13:44483084 C/A cg19180546 chr13:44453867 C13orf31;CCDC122 -0.45 -5.86 -0.34 1.39e-8 Leprosy; CESC cis rs910316 0.967 rs8013444 chr14:75661981 A/G cg08847533 chr14:75593920 NEK9 -0.93 -16.29 -0.71 8.2e-42 Height; CESC cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg20476274 chr7:133979776 SLC35B4 0.65 9.44 0.5 2.08e-18 Mean platelet volume; CESC cis rs2404602 0.622 rs4886506 chr15:77207277 G/T cg23625390 chr15:77176239 SCAPER 0.45 6.21 0.36 2.01e-9 Blood metabolite levels; CESC cis rs963731 0.649 rs4670903 chr2:39220975 G/A cg04010122 chr2:39346883 SOS1 -0.72 -5.36 -0.31 1.82e-7 Corticobasal degeneration; CESC cis rs9902453 1.000 rs9906340 chr17:28398977 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.64 -7.96 -0.44 5.11e-14 Coffee consumption (cups per day); CESC cis rs2361718 0.522 rs11867921 chr17:78121170 G/T cg23534315 chr17:78082725 GAA 0.43 5.61 0.33 5.12e-8 Yeast infection; CESC cis rs12912251 0.947 rs12899449 chr15:38995491 A/G cg01338139 chr15:38987640 C15orf53 -0.44 -5.03 -0.3 8.95e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs6570726 0.935 rs425717 chr6:145838620 A/T cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs950776 0.518 rs3813572 chr15:78832588 T/C cg06917634 chr15:78832804 PSMA4 0.81 12.32 0.6 6.91e-28 Sudden cardiac arrest; CESC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg19592336 chr6:28129416 ZNF389 0.46 6.19 0.36 2.28e-9 Parkinson's disease; CESC cis rs7072216 0.763 rs7923729 chr10:100169465 C/T cg26618903 chr10:100175079 PYROXD2 -0.37 -5.76 -0.33 2.33e-8 Metabolite levels; CESC cis rs9894429 0.789 rs6565611 chr17:79598319 T/C cg13777783 chr17:79615861 NA -0.33 -5.23 -0.31 3.49e-7 Eye color traits; CESC cis rs7178572 0.568 rs11630689 chr15:77520094 C/T cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC cis rs9640161 0.659 rs17837498 chr7:150009679 A/G cg10018233 chr7:150070692 REPIN1 0.46 7.32 0.41 2.89e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs9513593 1.000 rs2149262 chr13:99940671 C/G cg21788972 chr13:99853209 UBAC2 -0.56 -6.58 -0.37 2.47e-10 Psoriasis; CESC cis rs2040771 0.745 rs362148 chr22:19262852 T/C cg02655711 chr22:19163373 SLC25A1 0.4 5.75 0.33 2.48e-8 Metabolite levels (small molecules and protein measures); CESC cis rs17376456 0.569 rs2045019 chr5:93201971 C/T cg21475434 chr5:93447410 FAM172A -0.51 -5.17 -0.3 4.51e-7 Diabetic retinopathy; CESC cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg24110177 chr3:50126178 RBM5 -0.57 -7.93 -0.44 5.97e-14 Body mass index; CESC cis rs72781680 0.898 rs10490752 chr2:24025132 C/T cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg10253484 chr15:75165896 SCAMP2 -0.53 -7.05 -0.4 1.6e-11 Breast cancer; CESC cis rs6540555 0.505 rs11811440 chr1:209882900 C/A cg05527609 chr1:210001259 C1orf107 -0.72 -7.07 -0.4 1.37e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.43e-21 Prudent dietary pattern; CESC cis rs67517081 1 rs67517081 chr16:30987380 GT/G cg00531865 chr16:30841666 NA 0.48 6.25 0.36 1.61e-9 Mean corpuscular hemoglobin; CESC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg22535103 chr8:58192502 C8orf71 -0.96 -9.85 -0.52 1.05e-19 Developmental language disorder (linguistic errors); CESC cis rs5821446 1 rs5821446 chr17:65962538 A/AT cg12091567 chr17:66097778 LOC651250 0.74 8.68 0.47 4.07e-16 Eosinophil percentage of granulocytes; CESC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg22920501 chr2:26401640 FAM59B -0.86 -10.03 -0.52 2.73e-20 Gut microbiome composition (summer); CESC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg19717773 chr7:2847554 GNA12 -0.56 -8.04 -0.44 3.1e-14 Height; CESC cis rs17764205 0.713 rs17696611 chr19:3259171 C/A cg02612712 chr19:3985498 EEF2 0.65 5.1 0.3 6.36e-7 Bipolar disorder and schizophrenia; CESC cis rs4950928 0.823 rs2486065 chr1:203167871 A/G cg17014757 chr1:203156097 CHI3L1 -0.51 -5.11 -0.3 6.1e-7 YKL-40 levels; CESC cis rs7914558 1.000 rs12255047 chr10:104760752 G/A cg08650961 chr10:104748594 CNNM2 0.33 5.53 0.32 7.81e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs7246760 1.000 rs7246760 chr19:9918229 G/A cg02900749 chr2:68251473 NA -0.74 -6.84 -0.39 5.62e-11 Pursuit maintenance gain; CESC trans rs9325144 0.555 rs1843867 chr12:38703855 A/G cg23762105 chr12:34175262 ALG10 0.46 6.24 0.36 1.71e-9 Morning vs. evening chronotype; CESC cis rs1878931 0.697 rs10048148 chr16:3417450 C/G cg00484396 chr16:3507460 NAT15 -0.33 -5.03 -0.3 9.21e-7 Body mass index (adult); CESC cis rs7084402 0.967 rs1658478 chr10:60289551 C/T cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC trans rs62110082 0.522 rs10445582 chr19:52328510 T/C cg18094401 chr15:25434150 SNORD115-29;SNORD115-36;SNORD115-43;SNORD115-11 -0.6 -6.41 -0.37 6.74e-10 Bipolar disorder (body mass index interaction); CESC cis rs116095464 0.850 rs10055295 chr5:243749 G/A cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.27 0.31 2.9e-7 Breast cancer; CESC cis rs6089584 0.508 rs6061988 chr20:60626300 C/T cg24733560 chr20:60626293 TAF4 0.49 7.31 0.41 3.19e-12 Body mass index; CESC cis rs7666738 0.830 rs1869897 chr4:98730997 C/T cg03467027 chr4:99064603 C4orf37 0.43 5.31 0.31 2.33e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2290159 0.800 rs5746195 chr3:12653800 A/G cg23032965 chr3:12705835 RAF1 0.54 5.9 0.34 1.14e-8 Cholesterol, total; CESC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg05754148 chr16:3507555 NAT15 0.57 8.57 0.47 8.86e-16 Tuberculosis; CESC cis rs6547741 1.000 rs76784350 chr2:27764278 A/G cg21248554 chr2:27665150 KRTCAP3 0.25 5.16 0.3 4.9e-7 Oral cavity cancer; CESC cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 3.04e-8 Mean platelet volume; CESC trans rs61931739 0.517 rs11612493 chr12:34114272 A/C cg26384229 chr12:38710491 ALG10B 0.6 8.42 0.46 2.36e-15 Morning vs. evening chronotype; CESC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg08859206 chr1:53392774 SCP2 0.64 9.35 0.5 3.74e-18 Monocyte count; CESC cis rs2243480 0.908 rs55876148 chr7:65379800 G/A cg25894440 chr7:65020034 NA -0.62 -5.16 -0.3 4.73e-7 Diabetic kidney disease; CESC cis rs4132509 1.000 rs6429433 chr1:243857994 C/T cg21452805 chr1:244014465 NA 0.43 5.03 0.3 8.89e-7 RR interval (heart rate); CESC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg07414643 chr4:187882934 NA 0.55 7.93 0.44 6.16e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.11e-20 Prudent dietary pattern; CESC cis rs9660992 0.710 rs7367930 chr1:205235512 A/G cg21643547 chr1:205240462 TMCC2 -0.47 -6.28 -0.36 1.39e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs11785400 0.793 rs4301430 chr8:143737416 A/G cg10596483 chr8:143751796 JRK 0.41 5.11 0.3 6.08e-7 Schizophrenia; CESC cis rs2380220 0.935 rs7748857 chr6:96001887 A/G cg15832292 chr6:96025679 MANEA 0.63 5.99 0.35 6.89e-9 Behavioural disinhibition (generation interaction); CESC cis rs78944489 0.558 rs9917370 chr2:73480204 A/G cg01422370 chr2:73384389 NA 0.52 5.15 0.3 5.03e-7 Schizophrenia; CESC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 10.93 0.56 3.28e-23 Platelet count; CESC cis rs9611565 0.506 rs1984839 chr22:41685937 G/C cg06481639 chr22:41940642 POLR3H -0.53 -5.88 -0.34 1.21e-8 Vitiligo; CESC cis rs2262909 0.962 rs11667209 chr19:22259467 A/G cg11619707 chr19:22235551 ZNF257 0.33 5.17 0.3 4.65e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg05064044 chr6:292385 DUSP22 -0.65 -8.16 -0.45 1.38e-14 Menopause (age at onset); CESC cis rs6540556 0.608 rs4314885 chr1:209902704 G/A cg05527609 chr1:210001259 C1orf107 -0.44 -5.28 -0.31 2.68e-7 Red blood cell count; CESC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg22920501 chr2:26401640 FAM59B 0.89 9.91 0.52 6.61e-20 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg08470875 chr2:26401718 FAM59B -0.73 -7.98 -0.44 4.5e-14 Gut microbiome composition (summer); CESC cis rs2425143 0.818 rs6060726 chr20:34555878 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.11 -0.4 1.1e-11 Blood protein levels; CESC cis rs7703051 0.901 rs984976 chr5:74910870 A/G cg03227963 chr5:74354835 NA 0.28 5.06 0.3 7.8e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs9614461 0.609 rs9614653 chr22:45767391 A/G cg22884516 chr22:45809543 SMC1B;RIBC2 -0.54 -5.31 -0.31 2.37e-7 Tonsillectomy; CESC cis rs7129220 0.588 rs61878581 chr11:10083808 C/T cg01453529 chr11:10209919 SBF2 -0.46 -5.09 -0.3 6.9e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC trans rs1814175 0.645 rs7395438 chr11:49877379 G/T cg03929089 chr4:120376271 NA -0.87 -14.17 -0.66 2.64e-34 Height; CESC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg17949981 chr6:28129498 ZNF389 0.42 5.21 0.3 3.83e-7 Depression; CESC cis rs3126085 0.825 rs4298736 chr1:152240269 A/T cg03465714 chr1:152285911 FLG -0.45 -5.59 -0.32 5.7e-8 Atopic dermatitis; CESC cis rs4986811 1.000 rs2234582 chr11:32456694 C/A cg27409910 chr11:32454216 WT1 0.43 5.65 0.33 4.04e-8 Rubella-specific interleukin-6 secretion; CESC cis rs4654899 0.802 rs115818417 chr1:21200411 C/T cg05370193 chr1:21551575 ECE1 0.4 5.7 0.33 3.26e-8 Superior frontal gyrus grey matter volume; CESC cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg16850897 chr7:100343110 ZAN -0.61 -6.68 -0.38 1.37e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs17021463 0.807 rs6532480 chr4:95277038 T/C cg11021082 chr4:95130006 SMARCAD1 0.49 7.25 0.41 4.51e-12 Testicular germ cell tumor; CESC cis rs4803468 1.000 rs10853751 chr19:41903220 G/A cg08477640 chr19:41863820 B9D2 0.38 5.07 0.3 7.53e-7 Height; CESC cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg24879335 chr3:133465180 TF 0.47 9.17 0.49 1.4e-17 Iron status biomarkers (transferrin levels); CESC cis rs116095464 0.558 rs6882584 chr5:223411 A/C cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.74 0.33 2.63e-8 Breast cancer; CESC cis rs7580658 0.864 rs34832797 chr2:128119441 T/C cg10021288 chr2:128175891 PROC -0.41 -6.41 -0.37 6.54e-10 Protein C levels; CESC cis rs12618769 0.597 rs3769724 chr2:99105981 C/T cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.46 -6.01 -0.35 6.09e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7904368 0.754 rs7091240 chr10:16855683 G/A cg23933602 chr10:16859644 RSU1 0.66 6.14 0.35 2.97e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.2.1420302F chr2:62093097 NA 0.42 6.16 0.35 2.65e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs79387448 0.935 rs7567133 chr2:103253128 C/A cg15446670 chr7:87257547 ABCB1;RUNDC3B -0.55 -6.27 -0.36 1.43e-9 Gut microbiota (bacterial taxa); CESC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.47 5.61 0.33 5.08e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05001908 chr7:128045859 IMPDH1 -0.39 -6.15 -0.35 2.92e-9 Gambling; CESC cis rs61931739 0.500 rs11053274 chr12:34547605 G/A cg19457237 chr12:34500585 NA -0.37 -5.12 -0.3 5.85e-7 Morning vs. evening chronotype; CESC cis rs7193541 0.673 rs12716769 chr16:74652537 T/C cg05580060 chr16:74700937 RFWD3 -0.44 -5.64 -0.33 4.47e-8 Multiple myeloma; CESC cis rs72781680 0.898 rs12623316 chr2:24087857 A/G cg20701182 chr2:24300061 SF3B14 0.62 5.65 0.33 4.04e-8 Lymphocyte counts; CESC cis rs916888 0.773 rs199535 chr17:44822662 A/G cg27589368 chr17:43923255 LOC100128977;IMP5 -0.36 -5.11 -0.3 6.14e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.44 0.32 1.21e-7 Major depressive disorder; CESC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg09417038 chr21:47716443 C21orf57 -0.49 -6.88 -0.39 4.3e-11 Testicular germ cell tumor; CESC cis rs12971120 1.000 rs3829640 chr18:72174980 A/G cg26446133 chr18:72167187 CNDP2 -0.77 -10.27 -0.53 4.8e-21 Refractive error; CESC cis rs6723226 0.842 rs1901355 chr2:32835664 A/G cg02381751 chr2:32503542 YIPF4 -0.84 -11.35 -0.57 1.33e-24 Intelligence (multi-trait analysis); CESC cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg07636037 chr3:49044803 WDR6 1.06 18.94 0.76 3.54e-51 Parkinson's disease; CESC cis rs7631605 0.905 rs6786584 chr3:37225728 T/C cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.24 -0.31 3.21e-7 Cerebrospinal P-tau181p levels; CESC trans rs61931739 0.500 rs11053201 chr12:34453903 T/A cg13010199 chr12:38710504 ALG10B 0.48 6.28 0.36 1.38e-9 Morning vs. evening chronotype; CESC cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg18512352 chr11:47633146 NA -0.53 -7.86 -0.43 9.88e-14 Subjective well-being; CESC cis rs4243830 0.737 rs4908909 chr1:6599041 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.86 -7.53 -0.42 7.77e-13 Body mass index; CESC cis rs763121 0.853 rs5750652 chr22:39048316 A/G cg21395723 chr22:39101663 GTPBP1 0.5 6.66 0.38 1.6e-10 Menopause (age at onset); CESC cis rs796364 0.865 rs769948 chr2:200728475 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.89 8.76 0.47 2.4e-16 Schizophrenia; CESC cis rs910316 0.870 rs7147712 chr14:75670707 C/G cg08847533 chr14:75593920 NEK9 -0.93 -16.54 -0.71 1.07e-42 Height; CESC cis rs17125944 0.505 rs2274275 chr14:53235728 G/T cg13660082 chr14:53194042 PSMC6 -0.68 -5.9 -0.34 1.13e-8 Alzheimer's disease (late onset); CESC cis rs8141529 0.748 rs6005936 chr22:29289250 T/C cg15103426 chr22:29168792 CCDC117 0.61 8.06 0.44 2.58e-14 Lymphocyte counts; CESC cis rs3020736 0.500 rs7292241 chr22:42492063 G/A cg04733989 chr22:42467013 NAGA -0.82 -12.04 -0.59 6.5e-27 Autism spectrum disorder or schizophrenia; CESC cis rs7508 0.765 rs2898458 chr8:17913813 G/A cg18067069 chr8:17937731 ASAH1 -0.42 -5.34 -0.31 2.01e-7 Atrial fibrillation; CESC cis rs9611565 0.546 rs132793 chr22:42063681 A/G cg17376030 chr22:41985996 PMM1 -0.82 -8.87 -0.48 1.14e-16 Vitiligo; CESC cis rs7264396 0.690 rs17093156 chr20:34438583 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.35 0.41 2.49e-12 Total cholesterol levels; CESC cis rs28374715 0.662 rs72737786 chr15:41500361 G/T cg18705301 chr15:41695430 NDUFAF1 -0.79 -10.1 -0.53 1.63e-20 Ulcerative colitis; CESC cis rs9581857 0.615 rs79793528 chr13:28007823 G/A cg22138327 chr13:27999177 GTF3A 0.66 5.32 0.31 2.17e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg16049864 chr8:95962084 TP53INP1 -0.64 -11.11 -0.56 8.83e-24 Type 2 diabetes; CESC cis rs738322 0.967 rs133024 chr22:38574066 C/T cg17652424 chr22:38574118 PLA2G6 0.32 5.76 0.33 2.36e-8 Cutaneous nevi; CESC cis rs11112613 0.762 rs73184077 chr12:105949999 G/A cg03607813 chr12:105948248 NA 0.67 8.31 0.45 5.16e-15 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg25767906 chr1:53392781 SCP2 0.43 6.06 0.35 4.75e-9 Monocyte count; CESC cis rs6460942 0.915 rs2216050 chr7:12304073 T/C cg20607287 chr7:12443886 VWDE -0.41 -5.94 -0.34 8.83e-9 Coronary artery disease; CESC cis rs3762637 1.000 rs76599189 chr3:122124076 G/A cg24169773 chr3:122142474 KPNA1 -0.53 -6.19 -0.36 2.3e-9 LDL cholesterol levels; CESC cis rs4242434 0.927 rs3735901 chr8:22462374 T/C cg03733263 chr8:22462867 KIAA1967 0.96 16.09 0.7 4.03e-41 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs1707322 0.686 rs3014242 chr1:46087577 G/A cg03146154 chr1:46216737 IPP -0.79 -10.86 -0.55 5.89e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4450798 0.793 rs28687597 chr3:13757613 T/C cg23332027 chr3:13681764 NA 0.44 5.78 0.33 2.14e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9303280 0.901 rs7359623 chr17:38049589 C/T cg19468946 chr17:37922297 IKZF3 -0.4 -5.34 -0.31 1.98e-7 Self-reported allergy; CESC trans rs1814175 0.708 rs10839464 chr11:49981386 T/C cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs2197308 0.703 rs10880251 chr12:37903297 G/A cg26384229 chr12:38710491 ALG10B 0.75 11.12 0.56 8.21e-24 Morning vs. evening chronotype; CESC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg23281280 chr6:28129359 ZNF389 0.45 6.18 0.35 2.39e-9 Parkinson's disease; CESC cis rs7809950 0.678 rs62482499 chr7:106975059 C/G cg23024343 chr7:107201750 COG5 -0.5 -6.43 -0.37 5.78e-10 Coronary artery disease; CESC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03352830 chr11:487213 PTDSS2 0.75 7.61 0.42 4.93e-13 Body mass index; CESC cis rs1348850 0.567 rs4144276 chr2:178523420 T/C cg22681709 chr2:178499509 PDE11A -0.51 -7.49 -0.42 1.04e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8058578 0.887 rs28421305 chr16:30838128 G/A cg02466173 chr16:30829666 NA -0.48 -7.71 -0.43 2.61e-13 Multiple myeloma; CESC cis rs10743315 0.557 rs78468792 chr12:19351592 T/A cg02471346 chr12:19282374 PLEKHA5 0.69 5.14 0.3 5.24e-7 Gut microbiota (bacterial taxa); CESC cis rs916888 0.821 rs70600 chr17:44860021 C/T cg01570182 chr17:44337453 NA 0.91 10.47 0.54 1.11e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs7618501 1.000 rs1491986 chr3:49739086 C/T cg21659725 chr3:3221576 CRBN -0.82 -13.41 -0.64 1.16e-31 Intelligence (multi-trait analysis); CESC cis rs3733585 0.699 rs7663079 chr4:9966771 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.58 -0.32 5.91e-8 Cleft plate (environmental tobacco smoke interaction); CESC trans rs3942852 0.806 rs1503188 chr11:48117478 C/T cg03929089 chr4:120376271 NA -0.57 -6.48 -0.37 4.38e-10 Acute lymphoblastic leukemia (childhood); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14654587 chr19:1880126 FAM108A1 -0.62 -6.93 -0.39 3.16e-11 Gut microbiome composition (summer); CESC trans rs61931739 0.534 rs10844728 chr12:34020109 G/C cg26384229 chr12:38710491 ALG10B 0.59 8.24 0.45 8.19e-15 Morning vs. evening chronotype; CESC cis rs6089829 0.925 rs4809270 chr20:61676709 C/A cg16240275 chr20:61666158 NCRNA00029 0.49 8.29 0.45 5.66e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs9486719 0.895 rs12195315 chr6:96905711 T/G cg06623918 chr6:96969491 KIAA0776 -0.8 -8.21 -0.45 9.55e-15 Migraine;Coronary artery disease; CESC cis rs13082711 0.522 rs653886 chr3:27343549 C/T cg02860705 chr3:27208620 NA 0.39 5.22 0.31 3.69e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03046325 chr10:93558661 TNKS2 -0.4 -6.36 -0.36 8.99e-10 Gambling; CESC trans rs7618501 0.633 rs12485600 chr3:50025530 A/G cg21659725 chr3:3221576 CRBN 0.53 7.37 0.41 2.19e-12 Intelligence (multi-trait analysis); CESC cis rs11577318 0.853 rs4333841 chr1:26631927 T/C cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.46 -0.37 5.05e-10 Granulocyte percentage of myeloid white cells; CESC cis rs7851660 0.809 rs10984235 chr9:100660896 C/T cg13688889 chr9:100608707 NA -0.62 -8.87 -0.48 1.11e-16 Strep throat; CESC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.38 5.52 0.32 7.91e-8 Electroencephalogram traits; CESC cis rs611744 0.550 rs1448154 chr8:109281053 T/C cg21045802 chr8:109455806 TTC35 0.47 5.93 0.34 9.3e-9 Dupuytren's disease; CESC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg17724175 chr1:150552817 MCL1 0.33 5.18 0.3 4.4e-7 Melanoma; CESC cis rs6963495 0.585 rs1728653 chr7:105191335 A/G cg13798780 chr7:105162888 PUS7 0.49 5.8 0.34 1.93e-8 Bipolar disorder (body mass index interaction); CESC cis rs2769264 0.602 rs11204777 chr1:151072049 G/A cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.59 -6.58 -0.37 2.53e-10 Blood trace element (Cu levels); CESC cis rs2730245 1.000 rs2657365 chr7:158722753 A/T cg24397884 chr7:158709396 WDR60 -0.89 -13.45 -0.64 8.49e-32 Height; CESC cis rs11249608 0.548 rs2132672 chr5:178457742 A/C cg21905437 chr5:178450457 ZNF879 0.58 7.98 0.44 4.35e-14 Pubertal anthropometrics; CESC cis rs9488822 0.636 rs6937104 chr6:116375302 A/G cg18764771 chr6:116381957 FRK 0.24 5.9 0.34 1.09e-8 Cholesterol, total;LDL cholesterol; CESC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg10691866 chr7:65817282 TPST1 0.33 5.51 0.32 8.62e-8 Aortic root size; CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg11965913 chr1:205819406 PM20D1 -0.69 -11.65 -0.58 1.37e-25 Monocyte percentage of white cells; CESC cis rs1927790 0.697 rs61966875 chr13:96936525 C/A cg02571835 chr13:96230311 CLDN10 -0.39 -5.51 -0.32 8.55e-8 Body mass index; CESC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.04 -0.56 1.41e-23 Alzheimer's disease; CESC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg11494091 chr17:61959527 GH2 -0.76 -13.35 -0.63 1.91e-31 Prudent dietary pattern; CESC cis rs208520 1.000 rs12195505 chr6:66986279 T/A cg07460842 chr6:66804631 NA 0.88 10.12 0.53 1.49e-20 Exhaled nitric oxide output; CESC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg05564831 chr3:52568323 NT5DC2 0.47 7.46 0.42 1.24e-12 Bipolar disorder; CESC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs73019876 0.869 rs7247121 chr19:22161490 T/C cg11619707 chr19:22235551 ZNF257 -0.29 -5.43 -0.32 1.29e-7 Testicular germ cell tumor; CESC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC cis rs7762018 0.941 rs4716384 chr6:170109184 T/A cg05834625 chr6:170176447 C6orf70 0.64 7.53 0.42 8.16e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.51e-24 Menopause (age at onset); CESC cis rs2180341 0.814 rs9385424 chr6:127726796 A/G cg27446573 chr6:127587934 RNF146 0.83 12.03 0.59 6.99e-27 Breast cancer; CESC cis rs3008870 0.701 rs2815367 chr1:67500762 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.61 7.91 0.44 7.21e-14 Lymphocyte percentage of white cells; CESC cis rs8058578 0.943 rs3747486 chr16:30786927 C/T cg02466173 chr16:30829666 NA -0.39 -6.34 -0.36 9.69e-10 Multiple myeloma; CESC cis rs9399135 1.000 rs11754265 chr6:135356216 C/G cg24558204 chr6:135376177 HBS1L 0.49 6.69 0.38 1.33e-10 Red blood cell count; CESC cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg05340658 chr4:99064831 C4orf37 0.78 11.83 0.59 3.34e-26 Colonoscopy-negative controls vs population controls; CESC cis rs1577917 0.710 rs1059306 chr6:86388109 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.55 7.5 0.42 9.74e-13 Response to antipsychotic treatment; CESC cis rs863345 0.604 rs6666609 chr1:158498124 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.87 -0.39 4.57e-11 Pneumococcal bacteremia; CESC cis rs4243830 0.850 rs2412309 chr1:6603151 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.99 -10.01 -0.52 3.22e-20 Body mass index; CESC cis rs10489202 0.632 rs275137 chr1:168051266 A/C cg24449463 chr1:168025552 DCAF6 0.4 5.12 0.3 5.84e-7 Schizophrenia; CESC trans rs9951602 0.512 rs56009939 chr18:76644497 T/G cg02800362 chr5:177631904 HNRNPAB 0.62 8.1 0.45 1.96e-14 Obesity-related traits; CESC cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg05340658 chr4:99064831 C4orf37 0.77 11.71 0.58 8.52e-26 Colonoscopy-negative controls vs population controls; CESC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg11247378 chr22:39784982 NA 0.54 8.15 0.45 1.43e-14 IgG glycosylation; CESC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg14393609 chr7:65229607 NA 0.47 6.29 0.36 1.28e-9 Aortic root size; CESC cis rs6582630 0.638 rs61931383 chr12:38513845 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.78 -0.33 2.11e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg26343298 chr8:95960752 TP53INP1 0.37 6.1 0.35 3.7e-9 Type 2 diabetes; CESC cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg12463550 chr7:65579703 CRCP 0.55 6.89 0.39 4.02e-11 Aortic root size; CESC cis rs959260 1.000 rs4789181 chr17:73374640 T/A cg20590849 chr17:73267439 MIF4GD -0.58 -6.61 -0.38 2.14e-10 Systemic lupus erythematosus; CESC cis rs9314323 0.964 rs2304300 chr8:26249018 G/A cg11498726 chr8:26250323 BNIP3L -0.44 -6.6 -0.38 2.26e-10 Red cell distribution width; CESC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg14196790 chr5:131705035 SLC22A5 0.31 5.05 0.3 8.24e-7 Breast cancer; CESC cis rs16858210 0.648 rs79478990 chr3:183587094 C/T cg25686905 chr3:183603175 PARL -0.34 -6.21 -0.36 2.06e-9 Menopause (age at onset); CESC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg07677032 chr17:61819896 STRADA 0.46 6.12 0.35 3.27e-9 Prudent dietary pattern; CESC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg19346786 chr7:2764209 NA -0.45 -6.21 -0.36 2e-9 Height; CESC cis rs1005277 0.579 rs2800485 chr10:38542588 G/A cg25517755 chr10:38738941 LOC399744 -0.45 -5.74 -0.33 2.56e-8 Extrinsic epigenetic age acceleration; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04631757 chr12:58176492 TSFM -0.48 -6.21 -0.36 2.02e-9 Height; CESC cis rs7089973 0.584 rs7908665 chr10:116611337 G/A cg03647239 chr10:116582469 FAM160B1 0.48 6.17 0.35 2.52e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9649465 1.000 rs3807634 chr7:123382290 C/T cg04330084 chr7:123175371 IQUB -0.39 -5.18 -0.3 4.39e-7 Migraine; CESC cis rs2415984 0.579 rs10135740 chr14:46957379 G/A cg14871534 chr14:47121158 RPL10L -0.35 -5.22 -0.31 3.62e-7 Number of children ever born; CESC cis rs6088590 0.965 rs6120730 chr20:33385102 G/C cg08999081 chr20:33150536 PIGU 0.62 9.34 0.5 4.01e-18 Coronary artery disease; CESC cis rs2066819 1.000 rs78121408 chr12:56684798 C/T cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs9640161 0.789 rs34311995 chr7:150059255 T/C cg21361702 chr7:150065534 REPIN1 0.66 8.15 0.45 1.48e-14 Blood protein levels;Circulating chemerin levels; CESC cis rs7953249 0.564 rs1183910 chr12:121420807 G/A cg02403541 chr12:121454288 C12orf43 0.62 7.79 0.43 1.56e-13 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs4843747 0.671 rs8053377 chr16:88106465 A/G cg06915872 chr16:87998081 BANP 0.46 5.46 0.32 1.11e-7 Menopause (age at onset); CESC cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6690583 1.000 rs2304641 chr1:85513398 C/T cg22153463 chr1:85462885 MCOLN2 0.73 7.86 0.43 9.45e-14 Serum sulfate level; CESC cis rs6963495 0.818 rs75116202 chr7:105160059 C/T cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg22920501 chr2:26401640 FAM59B -0.67 -8.12 -0.45 1.72e-14 Gut microbiome composition (summer); CESC cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg23711669 chr6:146136114 FBXO30 0.97 14.77 0.67 2.05e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs6032067 0.929 rs17424723 chr20:43814520 G/T cg10761708 chr20:43804764 PI3 -0.44 -5.12 -0.3 5.94e-7 Blood protein levels; CESC cis rs2758596 0.850 rs2241110 chr1:156172487 A/G cg24450063 chr1:156163899 SLC25A44 0.84 8.69 0.47 3.84e-16 Paclitaxel disposition in epithelial ovarian cancer; CESC cis rs5753037 0.547 rs140140 chr22:30166437 G/A cg01021169 chr22:30184971 ASCC2 -0.56 -8.34 -0.46 4.19e-15 Type 1 diabetes; CESC cis rs367943 0.660 rs9632462 chr5:112697801 T/C cg12552261 chr5:112820674 MCC 0.43 5.58 0.32 6.06e-8 Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14095850 chr21:45196584 CSTB -0.42 -6.73 -0.38 1.02e-10 Gambling; CESC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.56 0.37 2.87e-10 Life satisfaction; CESC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg11890956 chr21:40555474 PSMG1 1.18 23.91 0.83 4.19e-68 Cognitive function; CESC cis rs7647973 1.000 rs7644148 chr3:49545241 G/A cg07636037 chr3:49044803 WDR6 -0.72 -10.25 -0.53 5.58e-21 Menarche (age at onset); CESC cis rs3768617 0.510 rs35968946 chr1:183114871 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 13.56 0.64 3.46e-32 Fuchs's corneal dystrophy; CESC cis rs2839186 0.605 rs2839170 chr21:47671305 A/G cg00815214 chr21:47717953 NA -0.35 -5.11 -0.3 6.22e-7 Testicular germ cell tumor; CESC cis rs7267979 1.000 rs4815404 chr20:25301845 T/G cg08601574 chr20:25228251 PYGB -0.39 -5.58 -0.32 5.94e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs79976124 0.877 rs79507557 chr6:66640908 C/A cg07460842 chr6:66804631 NA 0.72 8.33 0.46 4.47e-15 Type 2 diabetes; CESC cis rs6831352 0.918 rs13133647 chr4:100058727 C/T cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg00612595 chr21:47717864 NA 0.42 5.69 0.33 3.43e-8 Testicular germ cell tumor; CESC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg22903657 chr4:1355424 KIAA1530 -0.38 -5.26 -0.31 3.02e-7 Obesity-related traits; CESC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg06873352 chr17:61820015 STRADA 0.47 6.85 0.39 5.3e-11 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23439621 chr14:102228216 PPP2R5C -0.45 -6.08 -0.35 4.2e-9 Ulcerative colitis; CESC cis rs4654899 0.865 rs12123300 chr1:21323568 T/C cg05370193 chr1:21551575 ECE1 0.44 6.39 0.37 7.58e-10 Superior frontal gyrus grey matter volume; CESC cis rs9815354 1.000 rs7646144 chr3:41853125 T/A cg03022575 chr3:42003672 ULK4 0.54 5.78 0.33 2.06e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs7089973 0.872 rs7075888 chr10:116627117 C/T cg23260525 chr10:116636907 FAM160B1 0.38 6.42 0.37 6.35e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs3204270 0.500 rs62077175 chr17:79649568 G/T cg18367735 chr17:79674897 NA 0.62 5.38 0.31 1.61e-7 Dental caries; CESC cis rs7264396 0.635 rs6060673 chr20:34482396 C/T cg17201900 chr20:34330562 RBM39 -0.48 -5.07 -0.3 7.43e-7 Total cholesterol levels; CESC cis rs4474465 0.850 rs11237537 chr11:78248397 C/T cg01578073 chr11:78285783 NARS2 0.48 5.05 0.3 8.17e-7 Alzheimer's disease (survival time); CESC cis rs12579753 0.879 rs11115009 chr12:82165409 G/T cg23701643 chr12:82153290 PPFIA2 0.36 5.18 0.3 4.33e-7 Resting heart rate; CESC cis rs9522267 0.535 rs7326875 chr13:112236231 C/T cg10483660 chr13:112241077 NA -0.33 -5.78 -0.33 2.14e-8 Hepatitis; CESC cis rs3092073 0.624 rs11906879 chr20:44591324 C/T cg27529037 chr20:44575021 PCIF1 -0.64 -9.85 -0.52 1.06e-19 Intelligence (multi-trait analysis); CESC cis rs35110281 0.607 rs4819212 chr21:44977455 G/A cg01579765 chr21:45077557 HSF2BP -0.5 -8.14 -0.45 1.54e-14 Mean corpuscular volume; CESC cis rs72615157 0.539 rs72615159 chr7:99674286 G/A cg22004693 chr7:99632812 ZKSCAN1 0.43 5.48 0.32 9.67e-8 Lung function (FEV1/FVC); CESC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg03351412 chr1:154909251 PMVK -0.56 -7.01 -0.4 1.98e-11 Prostate cancer; CESC cis rs7582720 0.943 rs72936879 chr2:203792628 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.34 0.41 2.54e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs4423214 1.000 rs12791871 chr11:71164544 A/C cg05163923 chr11:71159392 DHCR7 0.76 10.16 0.53 1.05e-20 Vitamin D levels; CESC cis rs9457247 1.000 rs400063 chr6:167386592 C/T cg23791538 chr6:167370224 RNASET2 -0.59 -8.36 -0.46 3.55e-15 Crohn's disease; CESC cis rs45535039 1.000 rs12286018 chr11:119110947 G/A cg16724696 chr11:118992527 HINFP 0.39 5.08 0.3 7.18e-7 Plateletcrit; CESC cis rs8005677 0.828 rs12589539 chr14:23396680 A/G cg25600027 chr14:23388339 RBM23 -0.41 -5.07 -0.3 7.43e-7 Cognitive ability (multi-trait analysis); CESC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg23281280 chr6:28129359 ZNF389 0.53 7.01 0.4 1.92e-11 Depression; CESC trans rs6073597 1.000 rs6031980 chr20:43714384 C/T cg06899053 chr1:33896703 NA 0.43 6.1 0.35 3.72e-9 Positive affect; CESC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.08 0.4 1.32e-11 Height; CESC cis rs4594175 0.892 rs10135768 chr14:51671017 G/T cg23942311 chr14:51606299 NA 0.38 5.8 0.34 1.89e-8 Cancer; CESC cis rs55882075 0.583 rs9637934 chr5:179114025 G/C cg14593053 chr5:179126677 CANX 0.53 6.67 0.38 1.52e-10 Monocyte percentage of white cells; CESC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg17949981 chr6:28129498 ZNF389 -0.41 -5.37 -0.31 1.72e-7 Depression; CESC cis rs4704187 0.687 rs1544756 chr5:74508412 G/T cg03227963 chr5:74354835 NA 0.28 5.19 0.3 4.17e-7 Response to amphetamines; CESC cis rs8077889 0.871 rs7212648 chr17:41917962 A/C cg26893861 chr17:41843967 DUSP3 0.81 9.73 0.51 2.41e-19 Triglycerides; CESC cis rs11690935 1.000 rs34542126 chr2:172542705 C/T cg13550731 chr2:172543902 DYNC1I2 1.0 16.61 0.71 5.86e-43 Schizophrenia; CESC cis rs2274273 0.840 rs943590 chr14:55738596 T/C cg04306507 chr14:55594613 LGALS3 0.28 5.52 0.32 8.24e-8 Protein biomarker; CESC cis rs2204008 0.702 rs8175764 chr12:38363690 T/C cg26384229 chr12:38710491 ALG10B 0.73 10.95 0.56 2.81e-23 Bladder cancer; CESC cis rs2559856 1.000 rs10745921 chr12:102087193 A/G cg12213457 chr12:102090980 CHPT1 -0.34 -5.1 -0.3 6.45e-7 Blood protein levels; CESC cis rs12586317 0.547 rs2383693 chr14:35500205 A/C cg05294307 chr14:35346193 BAZ1A -0.54 -5.64 -0.33 4.35e-8 Psoriasis; CESC cis rs654950 0.840 rs116241899 chr1:41994546 T/C cg06885757 chr1:42089581 HIVEP3 -0.44 -6.82 -0.39 6.21e-11 Airway imaging phenotypes; CESC cis rs8072100 0.811 rs9889709 chr17:45445229 C/T cg25173405 chr17:45401733 C17orf57 -0.44 -5.72 -0.33 2.81e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs898097 0.841 rs8180 chr17:80901036 C/G cg15664640 chr17:80829946 TBCD 0.62 9.31 0.5 5.22e-18 Breast cancer; CESC cis rs6963495 0.818 rs55983796 chr7:105170941 C/T cg19920283 chr7:105172520 RINT1 0.68 6.44 0.37 5.53e-10 Bipolar disorder (body mass index interaction); CESC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg15145296 chr3:125709740 NA -0.54 -5.73 -0.33 2.67e-8 Blood pressure (smoking interaction); CESC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg18350739 chr11:68623251 NA -0.48 -7.45 -0.42 1.32e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04776990 chr17:42853002 ADAM11 -0.45 -6.38 -0.36 7.7e-10 Gambling; CESC cis rs6728642 0.908 rs9973669 chr2:97679094 T/C cg26665480 chr2:98280029 ACTR1B -0.81 -7.59 -0.42 5.47e-13 Bipolar disorder lithium response (continuous) or schizophrenia; CESC trans rs17685 0.753 rs10264760 chr7:75749694 A/G cg19862616 chr7:65841803 NCRNA00174 0.83 11.87 0.59 2.4e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs3820068 0.705 rs951225 chr1:15826292 G/A cg18192808 chr1:15853278 DNAJC16 0.47 5.78 0.33 2.05e-8 Systolic blood pressure; CESC cis rs12431939 0.948 rs12435444 chr14:51656071 C/T cg23942311 chr14:51606299 NA -0.41 -5.09 -0.3 6.8e-7 Cancer; CESC cis rs854765 0.616 rs8076747 chr17:17853595 C/T cg16928487 chr17:17741425 SREBF1 -0.54 -9.02 -0.48 4.02e-17 Total body bone mineral density; CESC cis rs2228479 0.867 rs17784386 chr16:89947457 A/G cg00800038 chr16:89945340 TCF25 -0.88 -7.85 -0.43 1.01e-13 Skin colour saturation; CESC cis rs2832077 0.943 rs2832097 chr21:30173340 A/T cg03476357 chr21:30257390 N6AMT1 0.47 5.07 0.3 7.63e-7 Cognitive test performance; CESC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg21280719 chr6:42927975 GNMT -0.31 -7.3 -0.41 3.43e-12 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg16606324 chr3:10149918 C3orf24 0.41 5.03 0.3 8.88e-7 Alzheimer's disease; CESC cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg18305652 chr10:134549665 INPP5A 0.33 5.3 0.31 2.41e-7 Migraine; CESC cis rs7847628 0.666 rs2031974 chr9:123527521 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.62 7.8 0.43 1.47e-13 Birth weight; CESC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.95 0.34 8.57e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9894429 0.738 rs8077038 chr17:79577127 T/G cg21984481 chr17:79567631 NPLOC4 0.58 9.48 0.5 1.5e-18 Eye color traits; CESC cis rs2710642 0.962 rs1828398 chr2:63034870 A/G cg17519650 chr2:63277830 OTX1 -0.52 -6.74 -0.38 9.98e-11 LDL cholesterol levels;LDL cholesterol; CESC cis rs9457247 0.663 rs9457257 chr6:167440736 G/A cg25258033 chr6:167368657 RNASET2 0.36 5.16 0.3 4.88e-7 Crohn's disease; CESC cis rs713587 0.563 rs2384057 chr2:25100167 C/G cg01884057 chr2:25150051 NA 0.34 6.36 0.36 8.69e-10 Body mass index in non-asthmatics; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27376817 chr7:75931888 HSPB1 -0.6 -6.98 -0.39 2.39e-11 Gut microbiome composition (summer); CESC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg23048001 chr7:2026167 MAD1L1 0.42 5.31 0.31 2.31e-7 Bipolar disorder and schizophrenia; CESC cis rs3772130 0.564 rs35178434 chr3:121595936 G/A cg20356878 chr3:121714668 ILDR1 0.42 6.19 0.36 2.32e-9 Cognitive performance; CESC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg08499158 chr17:42289980 UBTF 0.64 7.83 0.43 1.2e-13 Total body bone mineral density; CESC cis rs77106637 0.858 rs117819392 chr11:72514503 C/T cg03713592 chr11:72463424 ARAP1 1.22 11.0 0.56 2.03e-23 Type 2 diabetes; CESC cis rs858239 0.601 rs6461693 chr7:23160133 A/G cg23682824 chr7:23144976 KLHL7 -0.54 -7.47 -0.42 1.17e-12 Cerebrospinal fluid biomarker levels; CESC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.18 0.3 4.32e-7 Menopause (age at onset); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02576610 chr16:75657395 ADAT1 -0.45 -6.1 -0.35 3.69e-9 Asthma; CESC cis rs662064 0.962 rs648399 chr1:10556485 T/C cg20482658 chr1:10539492 PEX14 -0.36 -7.13 -0.4 9.5e-12 Asthma; CESC cis rs4704187 0.687 rs1345704 chr5:74489998 G/A cg03227963 chr5:74354835 NA 0.28 5.1 0.3 6.6e-7 Response to amphetamines; CESC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg21548813 chr6:291882 DUSP22 -0.45 -6.09 -0.35 4.01e-9 Menopause (age at onset); CESC trans rs17126268 0.502 rs9628983 chr1:102895348 A/T cg08072251 chr3:11033977 SLC6A1 0.47 6.11 0.35 3.56e-9 Glomerular filtration rate; CESC cis rs9487051 0.676 rs1608041 chr6:109595903 G/A cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs9910055 0.529 rs400460 chr17:42182770 A/G cg19774624 chr17:42201019 HDAC5 0.55 7.75 0.43 1.97e-13 Total body bone mineral density; CESC cis rs2274273 1.000 rs67805055 chr14:55587552 C/T cg04306507 chr14:55594613 LGALS3 0.3 5.5 0.32 8.9e-8 Protein biomarker; CESC cis rs2404618 0.593 rs7815979 chr8:1484887 A/G cg02903104 chr8:1507517 DLGAP2 0.3 5.87 0.34 1.27e-8 Lung cancer; CESC cis rs11583043 0.831 rs6667818 chr1:101412313 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.54 6.01 0.35 6.1e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg02187348 chr16:89574699 SPG7 -0.54 -7.4 -0.41 1.77e-12 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01801182 chr1:46998715 NA 0.5 6.01 0.35 6e-9 Gut microbiome composition (summer); CESC cis rs941207 0.526 rs12229457 chr12:57033680 T/A cg05584118 chr12:57595605 LRP1 0.39 5.12 0.3 5.99e-7 Platelet count; CESC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg04511125 chr2:88470314 THNSL2 0.64 6.24 0.36 1.7e-9 Plasma clusterin levels; CESC cis rs6121246 0.609 rs2149281 chr20:30417918 G/A cg13852791 chr20:30311386 BCL2L1 0.83 10.75 0.55 1.3e-22 Mean corpuscular hemoglobin; CESC cis rs4727963 0.765 rs1464877 chr7:122734266 G/A cg03640110 chr7:122635026 TAS2R16 0.4 6.2 0.36 2.14e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.32 5.27 0.31 2.82e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs4654899 0.785 rs9426656 chr1:21505932 T/G cg05370193 chr1:21551575 ECE1 0.39 6.04 0.35 5.15e-9 Superior frontal gyrus grey matter volume; CESC cis rs7914558 1.000 rs10883826 chr10:104830819 A/G cg15744005 chr10:104629667 AS3MT -0.33 -5.36 -0.31 1.77e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs11148252 0.904 rs9526927 chr13:53051627 C/T cg00495681 chr13:53174319 NA 0.38 5.13 0.3 5.5e-7 Lewy body disease; CESC cis rs2404602 0.692 rs1471780 chr15:77026526 T/C cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg14926445 chr8:58193284 C8orf71 -0.49 -5.31 -0.31 2.37e-7 Developmental language disorder (linguistic errors); CESC cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg24296786 chr1:45957014 TESK2 0.63 8.26 0.45 6.93e-15 High light scatter reticulocyte count; CESC cis rs7116495 1.000 rs548961 chr11:71793887 G/A cg10381502 chr11:71823885 C11orf51 -0.66 -5.4 -0.31 1.51e-7 Severe influenza A (H1N1) infection; CESC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.61 8.0 0.44 3.92e-14 Total body bone mineral density; CESC cis rs113835537 0.935 rs3867133 chr11:66451962 A/G cg24851651 chr11:66362959 CCS -0.62 -5.74 -0.33 2.64e-8 Airway imaging phenotypes; CESC cis rs4253772 0.637 rs6008357 chr22:46652104 T/G cg09491104 chr22:46646882 C22orf40 -0.59 -9.15 -0.49 1.58e-17 LDL cholesterol;Cholesterol, total; CESC cis rs7666738 0.791 rs10022061 chr4:98926821 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs11190604 1.000 rs2295772 chr10:102265183 G/A cg07080220 chr10:102295463 HIF1AN 0.64 5.88 0.34 1.23e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs2228479 0.850 rs62056103 chr16:89942781 G/A cg00800038 chr16:89945340 TCF25 -0.94 -7.79 -0.43 1.52e-13 Skin colour saturation; CESC cis rs1967309 0.604 rs8061182 chr16:4070333 A/G cg00061520 chr16:4070371 ADCY9 0.45 7.2 0.4 6.38e-12 Response to Dalcetrapib treatment in acute coronary syndrome; CESC cis rs7520050 0.807 rs3013595 chr1:46153203 G/A cg03146154 chr1:46216737 IPP 0.52 6.86 0.39 4.96e-11 Red blood cell count;Reticulocyte count; CESC cis rs6541297 1.000 rs6681042 chr1:230278979 G/A cg20703242 chr1:230279135 GALNT2 0.68 10.87 0.56 5.47e-23 Coronary artery disease; CESC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg07677032 chr17:61819896 STRADA 0.44 5.9 0.34 1.1e-8 Prudent dietary pattern; CESC cis rs79390637 1 rs79390637 chr11:47456867 C/A cg20307385 chr11:47447363 PSMC3 0.5 6.09 0.35 3.87e-9 Intraocular pressure; CESC cis rs950169 0.922 rs12915832 chr15:85111457 C/T cg17507749 chr15:85114479 UBE2QP1 0.54 6.27 0.36 1.49e-9 Schizophrenia; CESC cis rs17376456 0.877 rs17374627 chr5:93296306 C/T cg21475434 chr5:93447410 FAM172A 0.76 6.55 0.37 2.97e-10 Diabetic retinopathy; CESC cis rs7267979 1.000 rs7268053 chr20:25328286 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.09 -0.74 3.41e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg03433033 chr1:76189801 ACADM -0.67 -7.85 -0.43 1.05e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs8018808 0.935 rs4903584 chr14:77934758 A/G cg20045696 chr14:77926864 AHSA1 0.43 5.9 0.34 1.13e-8 Myeloid white cell count; CESC cis rs9916302 0.904 rs10491128 chr17:37551988 G/A cg20243544 chr17:37824526 PNMT -0.49 -5.92 -0.34 9.98e-9 Glomerular filtration rate (creatinine); CESC cis rs9911578 1.000 rs6503887 chr17:56993320 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.39 5.05 0.3 8.26e-7 Intelligence (multi-trait analysis); CESC cis rs72627123 0.867 rs79250763 chr14:74491121 G/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.8 5.37 0.31 1.71e-7 Morning vs. evening chronotype; CESC cis rs8018808 0.935 rs4899655 chr14:77898077 G/A cg20045696 chr14:77926864 AHSA1 0.42 5.85 0.34 1.43e-8 Myeloid white cell count; CESC cis rs7000551 0.725 rs2461486 chr8:22392008 T/C cg12081754 chr8:22256438 SLC39A14 0.38 5.11 0.3 6.05e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs561341 0.824 rs1978115 chr17:30220776 A/C cg12193833 chr17:30244370 NA -0.59 -6.1 -0.35 3.82e-9 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4072980 0.545 rs10890285 chr1:38453576 A/C cg17077180 chr1:38461687 NA -0.42 -5.87 -0.34 1.28e-8 Coronary artery disease; CESC cis rs12479064 0.604 rs11893359 chr2:99954608 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.56 -6.87 -0.39 4.44e-11 Chronic sinus infection; CESC cis rs710216 0.917 rs900836 chr1:43412727 T/C cg03128534 chr1:43423976 SLC2A1 -0.56 -6.49 -0.37 4.09e-10 Red cell distribution width; CESC cis rs4901847 0.643 rs36051876 chr14:58596241 C/T cg15908186 chr14:58618357 C14orf37 0.35 5.15 0.3 4.98e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs642803 0.551 rs1308020 chr11:65497558 G/A cg02870584 chr11:65547924 DKFZp761E198 0.54 6.71 0.38 1.18e-10 Urate levels; CESC cis rs2637266 0.935 rs1866891 chr10:78396941 C/A cg18941641 chr10:78392320 NA 0.45 8.6 0.47 7.12e-16 Pulmonary function; CESC cis rs2481665 0.775 rs2476201 chr1:62619960 C/T cg18591186 chr1:62594603 INADL 0.52 6.16 0.35 2.62e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4253772 0.591 rs9615935 chr22:46686115 T/G cg18190219 chr22:46762943 CELSR1 -0.59 -5.46 -0.32 1.09e-7 LDL cholesterol;Cholesterol, total; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg24896697 chr17:25660093 NA 0.5 6.09 0.35 3.96e-9 Psoriatic arthritis; CESC cis rs4853525 0.522 rs6434412 chr2:191585275 A/G cg10560079 chr2:191398806 TMEM194B -0.42 -5.3 -0.31 2.43e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; CESC cis rs1728785 1.000 rs1364109 chr16:68595505 T/C cg02972257 chr16:68554789 NA -0.59 -6.7 -0.38 1.23e-10 Ulcerative colitis; CESC cis rs8018808 1.000 rs2193595 chr14:77845121 A/G cg20045696 chr14:77926864 AHSA1 -0.38 -5.18 -0.3 4.32e-7 Myeloid white cell count; CESC cis rs854765 0.551 rs12600546 chr17:17867614 A/G cg09796270 chr17:17721594 SREBF1 0.45 6.17 0.35 2.61e-9 Total body bone mineral density; CESC cis rs9611565 0.512 rs9611672 chr22:42209922 A/G cg06481639 chr22:41940642 POLR3H -0.58 -5.61 -0.33 5.08e-8 Vitiligo; CESC cis rs116095464 0.558 rs10076655 chr5:239464 G/C cg22496380 chr5:211416 CCDC127 -0.76 -8.92 -0.48 8.07e-17 Breast cancer; CESC cis rs4588572 0.686 rs4352584 chr5:77682948 C/G cg11547950 chr5:77652471 NA 0.46 5.94 0.34 8.76e-9 Triglycerides; CESC cis rs9457247 0.756 rs2345572 chr6:167403441 A/T cg23791538 chr6:167370224 RNASET2 -0.57 -8.05 -0.44 2.77e-14 Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23549086 chr19:8008681 TIMM44 -0.44 -6.03 -0.35 5.6e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.06 0.3 7.76e-7 Tonsillectomy; CESC cis rs2806561 0.765 rs2806556 chr1:23502850 G/A cg12483005 chr1:23474871 LUZP1 0.39 6.21 0.36 2.06e-9 Height; CESC cis rs5769707 0.967 rs2187891 chr22:49994094 C/T cg05373962 chr22:49881684 NA -0.32 -5.25 -0.31 3.15e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs2985684 0.894 rs4900928 chr14:50020817 A/G cg02151108 chr14:50098012 C14orf104 -0.38 -5.13 -0.3 5.64e-7 Carotid intima media thickness; CESC cis rs34638657 0.789 rs2967363 chr16:82204132 C/G cg09439754 chr16:82129088 HSD17B2 -0.38 -6.04 -0.35 5.1e-9 Lung adenocarcinoma; CESC cis rs2637266 0.745 rs2583039 chr10:78440187 A/G cg18941641 chr10:78392320 NA 0.42 7.82 0.43 1.27e-13 Pulmonary function; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg23682824 chr7:23144976 KLHL7 -0.49 -7.43 -0.42 1.49e-12 Vertical cup-disc ratio; CESC cis rs72781680 1.000 rs72798418 chr2:24188922 A/G cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.56e-8 Lymphocyte counts; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21164723 chr1:214776304 CENPF -0.45 -7.06 -0.4 1.48e-11 Gambling; CESC cis rs962856 1.000 rs6546294 chr2:67562230 C/T cg09028215 chr2:67624308 ETAA1 -0.4 -5.11 -0.3 6.19e-7 Pancreatic cancer; CESC cis rs950169 0.922 rs12912934 chr15:85114447 C/T cg17507749 chr15:85114479 UBE2QP1 0.54 6.11 0.35 3.61e-9 Schizophrenia; CESC cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg22875332 chr1:76189707 ACADM 0.63 7.58 0.42 5.7e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4466137 0.904 rs6887104 chr5:83003535 G/A cg16102102 chr5:83017553 HAPLN1 -0.47 -6.74 -0.38 9.88e-11 Prostate cancer; CESC cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg26516362 chr5:178986906 RUFY1 0.45 6.96 0.39 2.64e-11 Lung cancer; CESC cis rs2742234 0.541 rs10793422 chr10:43703874 G/A cg15436174 chr10:43711423 RASGEF1A 0.5 5.91 0.34 1.06e-8 Hirschsprung disease; CESC cis rs4975616 0.714 rs27069 chr5:1347128 C/T cg06550200 chr5:1325588 CLPTM1L -0.64 -9.39 -0.5 2.83e-18 Lung cancer; CESC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg07507251 chr3:52567010 NT5DC2 0.36 5.76 0.33 2.31e-8 Bipolar disorder; CESC cis rs2797160 0.967 rs2226158 chr6:125995467 C/T cg05901451 chr6:126070800 HEY2 -0.45 -6.39 -0.37 7.52e-10 Endometrial cancer; CESC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg09509183 chr1:209979624 IRF6 0.48 6.04 0.35 5.18e-9 Cleft lip with or without cleft palate; CESC cis rs6460942 0.908 rs73677570 chr7:12280329 T/C cg20607287 chr7:12443886 VWDE -0.55 -5.86 -0.34 1.38e-8 Coronary artery disease; CESC cis rs1055129 0.516 rs7218498 chr17:73931847 C/G cg02678768 chr17:74002944 EVPL 0.4 5.67 0.33 3.69e-8 White matter hyperintensity burden; CESC cis rs3749237 0.595 rs1464568 chr3:49458266 G/A cg02487422 chr3:49467188 NICN1 0.54 8.03 0.44 3.17e-14 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14788749 chr22:35937309 RASD2 0.58 6.1 0.35 3.83e-9 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16418258 chr15:42840397 LRRC57;HAUS2 0.44 5.99 0.35 6.66e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs3780486 0.505 rs10217267 chr9:33146528 T/C cg04842962 chr6:43655489 MRPS18A 0.67 10.02 0.52 3.02e-20 IgG glycosylation; CESC cis rs4891159 0.505 rs680253 chr18:74167427 A/C cg24786174 chr18:74118243 ZNF516 -0.77 -13.54 -0.64 4.12e-32 Longevity; CESC cis rs921968 0.565 rs2272191 chr2:219609776 G/A cg02176678 chr2:219576539 TTLL4 -0.47 -8.3 -0.45 5.29e-15 Mean corpuscular hemoglobin concentration; CESC cis rs763014 0.931 rs7191939 chr16:630089 C/T cg07256732 chr16:621771 PIGQ -0.3 -5.07 -0.3 7.46e-7 Height; CESC cis rs796364 0.951 rs7608668 chr2:201000017 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -6.3 -0.36 1.24e-9 Schizophrenia; CESC cis rs1577917 0.958 rs34622605 chr6:86456519 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.53 -6.89 -0.39 4.05e-11 Response to antipsychotic treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12893361 chr12:122124854 NA 0.59 6.72 0.38 1.12e-10 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11948421 chr20:3451504 ATRN -0.49 -6.05 -0.35 4.92e-9 Ulcerative colitis; CESC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.83 0.34 1.58e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg22823121 chr1:150693482 HORMAD1 0.47 6.57 0.37 2.6e-10 Melanoma; CESC cis rs72945132 0.882 rs60917762 chr11:70211384 C/T cg14191688 chr11:70257035 CTTN 0.4 5.05 0.3 8.19e-7 Coronary artery disease; CESC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg00166722 chr3:10149974 C3orf24 0.5 6.37 0.36 8.41e-10 Alzheimer's disease; CESC cis rs11711311 1.000 rs9854504 chr3:113532381 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.58 7.58 0.42 5.99e-13 IgG glycosylation; CESC cis rs2463822 0.925 rs74692811 chr11:62156572 G/A cg06239285 chr11:62104954 ASRGL1 -0.89 -8.83 -0.48 1.48e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs1801251 1.000 rs35085837 chr2:233624363 A/G cg25237894 chr2:233734115 C2orf82 0.45 7.9 0.44 7.6e-14 Coronary artery disease; CESC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg23985595 chr17:80112537 CCDC57 0.41 6.42 0.37 6.41e-10 Life satisfaction; CESC cis rs965469 0.895 rs6051843 chr20:3400538 A/G cg25506879 chr20:3388711 C20orf194 -0.63 -6.55 -0.37 3.01e-10 IFN-related cytopenia; CESC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg24503407 chr1:205819492 PM20D1 0.53 7.89 0.44 7.89e-14 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26069066 chr20:44044698 PIGT 0.58 6.95 0.39 2.88e-11 Gut microbiome composition (summer); CESC cis rs12893668 0.667 rs11844466 chr14:104066422 G/A cg24130564 chr14:104152367 KLC1 -0.51 -6.38 -0.36 7.91e-10 Reticulocyte count; CESC cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.67 0.61 4.33e-29 Colonoscopy-negative controls vs population controls; CESC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg12963246 chr6:28129442 ZNF389 0.41 5.97 0.34 7.4e-9 Cardiac Troponin-T levels; CESC cis rs2270431 1 rs2270431 chr14:75270635 T/C cg08847533 chr14:75593920 NEK9 0.47 5.85 0.34 1.43e-8 Neuroticism; CESC cis rs589448 0.872 rs315111 chr12:69784695 G/A cg20891283 chr12:69753455 YEATS4 0.96 16.03 0.7 7.07e-41 Cerebrospinal fluid biomarker levels; CESC cis rs76419734 0.510 rs12511885 chr4:106662118 G/A cg24545054 chr4:106630052 GSTCD;INTS12 0.7 8.63 0.47 5.96e-16 Post bronchodilator FEV1; CESC cis rs72781680 0.950 rs56128748 chr2:24126809 T/G cg20701182 chr2:24300061 SF3B14 0.63 5.64 0.33 4.33e-8 Lymphocyte counts; CESC cis rs67311347 1.000 rs73076035 chr3:40439881 G/C cg24209194 chr3:40518798 ZNF619 0.5 6.13 0.35 3.09e-9 Renal cell carcinoma; CESC cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg23649088 chr2:200775458 C2orf69 0.75 9.44 0.5 2.06e-18 Osteoporosis; CESC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg00149659 chr3:10157352 C3orf10 0.73 9.0 0.48 4.43e-17 Alzheimer's disease; CESC cis rs3015497 0.583 rs3783408 chr14:51000193 C/T cg26011998 chr14:51135199 SAV1 0.51 5.78 0.33 2.05e-8 Mean platelet volume; CESC cis rs34779708 0.966 rs12761675 chr10:35438337 C/T cg03585969 chr10:35415529 CREM -0.74 -9.67 -0.51 3.9e-19 Inflammatory bowel disease;Crohn's disease; CESC trans rs877282 0.898 rs12354872 chr10:763362 G/A cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg11764359 chr7:65958608 NA 0.61 7.44 0.42 1.43e-12 Aortic root size; CESC cis rs17253792 0.730 rs77079997 chr14:56155250 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.39 0.31 1.58e-7 Putamen volume; CESC cis rs7772486 0.686 rs9485019 chr6:146046381 C/G cg23711669 chr6:146136114 FBXO30 -0.89 -13.24 -0.63 4.85e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg05347473 chr6:146136440 FBXO30 -0.7 -8.98 -0.48 5.21e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.52 0.37 3.51e-10 Bipolar disorder; CESC cis rs9859260 0.744 rs3933 chr3:195784997 C/T cg12923728 chr3:195709715 SDHAP1 0.5 6.59 0.38 2.39e-10 Mean corpuscular volume; CESC cis rs4595586 0.563 rs11169769 chr12:39233134 C/G cg13010199 chr12:38710504 ALG10B 0.57 7.66 0.43 3.45e-13 Morning vs. evening chronotype; CESC cis rs7712401 0.601 rs154501 chr5:122211594 T/C cg19412675 chr5:122181750 SNX24 0.41 5.06 0.3 7.77e-7 Mean platelet volume; CESC cis rs28489187 0.617 rs7547571 chr1:85884091 G/T cg16011679 chr1:85725395 C1orf52 -0.43 -5.18 -0.3 4.43e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs35079168 0.809 rs11103483 chr9:137287874 G/A cg13941235 chr9:137270186 RXRA -0.31 -5.66 -0.33 3.86e-8 Intelligence; CESC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg23982607 chr1:1823379 GNB1 -0.78 -12.68 -0.61 4.08e-29 Body mass index; CESC cis rs7671266 0.668 rs10007416 chr4:10159457 T/C cg11266682 chr4:10021025 SLC2A9 -0.48 -6.0 -0.35 6.29e-9 Cardiovascular disease risk factors; CESC cis rs8072100 0.688 rs7221224 chr17:45419061 T/G cg08085267 chr17:45401833 C17orf57 0.52 6.46 0.37 4.88e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9488822 0.676 rs12196579 chr6:116351724 G/T cg05304507 chr6:116381966 FRK 0.26 6.59 0.38 2.37e-10 Cholesterol, total;LDL cholesterol; CESC cis rs9908102 0.710 rs56317483 chr17:12904995 T/G cg26162695 chr17:12921313 ELAC2 0.53 5.82 0.34 1.69e-8 Schizophrenia; CESC cis rs4728302 0.869 rs10255193 chr7:133608911 C/G cg10665199 chr7:133106180 EXOC4 0.4 5.56 0.32 6.69e-8 Intelligence;Intelligence (multi-trait analysis); CESC trans rs60380162 0.963 rs4281305 chr1:87725937 T/G cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.03 -0.35 5.48e-9 Loneliness (linear analysis); CESC cis rs2153904 0.793 rs12748961 chr1:205676263 T/C cg23034840 chr1:205782522 SLC41A1 -0.56 -5.17 -0.3 4.59e-7 Prostate-specific antigen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09015028 chr6:116892464 RWDD1 0.57 6.48 0.37 4.47e-10 Gut microbiome composition (summer); CESC cis rs2721195 0.719 rs4925812 chr8:145808035 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 0.77 11.17 0.57 5.32e-24 Age at first birth; CESC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg23590916 chr17:43697445 MGC57346 -0.61 -6.51 -0.37 3.66e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6499255 0.951 rs8052086 chr16:69692468 A/C cg15192750 chr16:69999425 NA 0.5 5.77 0.33 2.19e-8 IgE levels; CESC cis rs909674 0.515 rs9611170 chr22:39784845 G/C cg24399712 chr22:39784796 NA -0.88 -12.52 -0.61 1.44e-28 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7927592 0.912 rs55767696 chr11:68375120 C/G cg16797656 chr11:68205561 LRP5 0.4 5.69 0.33 3.34e-8 Total body bone mineral density; CESC cis rs7980687 0.657 rs10744151 chr12:123723735 G/C cg19016782 chr12:123741754 C12orf65 -0.36 -5.31 -0.31 2.34e-7 Height;Educational attainment;Head circumference (infant); CESC cis rs854765 0.583 rs4925123 chr17:17784374 A/G cg16928487 chr17:17741425 SREBF1 0.61 10.73 0.55 1.58e-22 Total body bone mineral density; CESC trans rs4950322 0.580 rs7541393 chr1:146588768 C/T cg04954894 chr8:38089920 DDHD2 -0.59 -6.43 -0.37 5.98e-10 Protein quantitative trait loci; CESC cis rs1559088 1.000 rs1974783 chr19:33551507 C/G cg17764715 chr19:33622953 WDR88 0.45 5.68 0.33 3.6e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10844818 chr11:60609393 CCDC86 0.43 6.09 0.35 3.98e-9 Systemic lupus erythematosus; CESC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg11301795 chr4:187892539 NA -0.81 -14.54 -0.67 1.34e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg22823121 chr1:150693482 HORMAD1 0.4 5.68 0.33 3.61e-8 Melanoma; CESC cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg14784868 chr12:69753453 YEATS4 0.84 13.21 0.63 6.15e-31 Blood protein levels; CESC cis rs12188164 0.543 rs2434694 chr5:462734 C/T cg16584290 chr5:462447 EXOC3 0.47 7.09 0.4 1.19e-11 Cystic fibrosis severity; CESC cis rs4718428 0.705 rs62465692 chr7:66295745 T/C cg12165864 chr7:66369176 NA -0.64 -7.21 -0.4 5.96e-12 Corneal structure; CESC cis rs9911578 1.000 rs1057068 chr17:56598439 T/C cg12560992 chr17:57184187 TRIM37 -0.92 -15.35 -0.69 1.7e-38 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07664667 chr16:778351 HAGHL -0.41 -6.16 -0.35 2.67e-9 Gambling; CESC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg11247378 chr22:39784982 NA -0.66 -9.78 -0.51 1.76e-19 Intelligence (multi-trait analysis); CESC cis rs9487051 0.676 rs6929438 chr6:109595506 C/T cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 9.03e-8 Reticulocyte fraction of red cells; CESC cis rs4523957 0.855 rs12601834 chr17:2112431 C/T cg16513277 chr17:2031491 SMG6 -0.65 -9.02 -0.48 4.04e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs2207136 0.868 rs7769860 chr6:50831567 C/T cg06522515 chr3:184090630 THPO -0.38 -6.63 -0.38 1.9e-10 Myopia; CESC trans rs208520 0.690 rs7764570 chr6:66827600 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -11.22 -0.57 3.54e-24 Exhaled nitric oxide output; CESC cis rs8060686 0.623 rs28700885 chr16:68154544 A/G cg26727032 chr16:67993705 SLC12A4 -0.58 -8.16 -0.45 1.34e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs6963495 0.818 rs56251768 chr7:105165591 A/G cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg18337363 chr3:52569053 NT5DC2 0.29 5.12 0.3 5.79e-7 Bipolar disorder; CESC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg05255149 chr17:80675120 FN3KRP 0.46 5.05 0.3 8.13e-7 Glycated hemoglobin levels; CESC cis rs2651899 0.902 rs1624023 chr1:3079337 C/T cg07622451 chr1:3079886 PRDM16 0.31 5.57 0.32 6.33e-8 Migraine; CESC cis rs1707322 1.000 rs10890353 chr1:46298383 G/T cg06784218 chr1:46089804 CCDC17 0.32 5.47 0.32 1.04e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9902453 0.817 rs2729435 chr17:28121532 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -8.47 -0.46 1.74e-15 Coffee consumption (cups per day); CESC cis rs34172651 0.917 rs11640931 chr16:24797919 A/G cg06028605 chr16:24865363 SLC5A11 0.35 5.43 0.32 1.25e-7 Intelligence (multi-trait analysis); CESC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.59 -7.75 -0.43 2.02e-13 Prudent dietary pattern; CESC cis rs2180341 0.920 rs7756880 chr6:127683999 A/T cg24812749 chr6:127587940 RNF146 1.05 15.07 0.68 1.77e-37 Breast cancer; CESC cis rs2952156 0.920 rs2517954 chr17:37843550 T/C cg07936489 chr17:37558343 FBXL20 -0.52 -6.23 -0.36 1.79e-9 Asthma; CESC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11792861 0.816 rs7021366 chr9:111727670 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.53 6.66 0.38 1.55e-10 Menarche (age at onset); CESC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg11494091 chr17:61959527 GH2 0.73 12.39 0.61 4.19e-28 Prudent dietary pattern; CESC cis rs7998202 0.667 rs282583 chr13:113349642 G/T cg02820901 chr13:113351484 ATP11A 0.63 5.96 0.34 7.8e-9 Glycated hemoglobin levels; CESC cis rs2479106 0.656 rs10117940 chr9:126469730 A/G cg16191174 chr9:126692580 DENND1A 0.42 5.3 0.31 2.41e-7 Polycystic ovary syndrome; CESC cis rs854765 0.618 rs8068820 chr17:17834119 A/G cg04398451 chr17:18023971 MYO15A -0.67 -9.61 -0.51 6.01e-19 Total body bone mineral density; CESC cis rs7216064 1.000 rs2128792 chr17:65857177 C/T cg12091567 chr17:66097778 LOC651250 -0.85 -8.7 -0.47 3.54e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg20135002 chr11:47629003 NA -0.4 -5.1 -0.3 6.41e-7 Subjective well-being; CESC cis rs8103278 0.507 rs10401971 chr19:46261982 C/T cg11657440 chr19:46296263 DMWD 0.77 11.86 0.59 2.54e-26 Coronary artery disease; CESC cis rs710216 0.843 rs710214 chr1:43439282 C/T cg03128534 chr1:43423976 SLC2A1 0.49 5.46 0.32 1.12e-7 Red cell distribution width; CESC cis rs9323205 0.862 rs11629399 chr14:51612814 T/C cg23942311 chr14:51606299 NA -0.45 -5.75 -0.33 2.5e-8 Cancer; CESC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.93 10.32 0.54 3.22e-21 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00400810 chr15:42066822 MAPKBP1 0.65 7.27 0.41 4.09e-12 Gut microbiome composition (summer); CESC cis rs11792861 0.816 rs3818932 chr9:111664178 T/C cg05043794 chr9:111880884 C9orf5 -0.37 -6.19 -0.36 2.33e-9 Menarche (age at onset); CESC cis rs782590 0.902 rs782602 chr2:55849309 A/G cg18811423 chr2:55921094 PNPT1 0.76 11.71 0.58 8.62e-26 Metabolic syndrome; CESC cis rs10131894 0.611 rs174995 chr14:75434183 T/C cg08847533 chr14:75593920 NEK9 -0.75 -11.77 -0.59 5.43e-26 Coronary artery disease; CESC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg02574844 chr11:5959923 NA -0.48 -6.97 -0.39 2.49e-11 DNA methylation (variation); CESC trans rs2727020 0.521 rs2088526 chr11:49531968 G/A cg03929089 chr4:120376271 NA 0.69 7.89 0.44 8.11e-14 Coronary artery disease; CESC cis rs72945132 0.769 rs680571 chr11:70187441 G/A cg14191688 chr11:70257035 CTTN 0.43 5.51 0.32 8.64e-8 Coronary artery disease; CESC cis rs11696501 0.688 rs11696685 chr20:44295134 A/G cg11783356 chr20:44313418 WFDC10B -0.34 -5.19 -0.3 4.2e-7 Brain structure; CESC cis rs4662945 0.603 rs10496678 chr2:130262209 C/T cg05903289 chr2:130345205 NA -0.42 -6.21 -0.36 2.03e-9 Response to cytidine analogues (gemcitabine); CESC cis rs5758659 0.714 rs7245 chr22:42481849 G/A cg05082376 chr22:42548792 NA 0.36 5.17 0.3 4.67e-7 Cognitive function; CESC cis rs11626933 1.000 rs45463097 chr14:90744188 G/A cg14092571 chr14:90743983 NA -0.98 -15.22 -0.68 5.3e-38 Gut microbiota (bacterial taxa); CESC cis rs6867032 1.000 rs7729761 chr5:2015783 G/T cg26168224 chr5:2018326 NA 0.96 19.64 0.77 1.3e-53 Gut microbiome composition (winter); CESC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg24549020 chr5:56110836 MAP3K1 0.59 6.73 0.38 1.06e-10 Initial pursuit acceleration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11306783 chr4:25314649 ZCCHC4 0.45 6.17 0.35 2.52e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs35110281 0.805 rs3788062 chr21:44991159 C/T cg01579765 chr21:45077557 HSF2BP -0.58 -10.06 -0.53 2.19e-20 Mean corpuscular volume; CESC cis rs1943345 0.556 rs523414 chr11:82910666 C/G cg07047830 chr11:82868014 PCF11 0.41 5.11 0.3 6.13e-7 Obesity-related traits; CESC cis rs4588572 0.688 rs2362829 chr5:77724036 T/A cg11547950 chr5:77652471 NA -0.4 -5.47 -0.32 1.03e-7 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25713684 chr10:105127687 TAF5 -0.56 -6.19 -0.36 2.25e-9 Gut microbiome composition (summer); CESC trans rs3960554 0.696 rs10952869 chr7:75846453 A/G cg19862616 chr7:65841803 NCRNA00174 0.58 7.13 0.4 9.31e-12 Eotaxin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20866375 chr17:3572559 TAX1BP3;TMEM93 0.59 6.53 0.37 3.41e-10 Gut microbiome composition (summer); CESC cis rs11608355 0.515 rs7136048 chr12:109903926 A/G cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7520050 0.931 rs6686134 chr1:46378268 A/G cg24296786 chr1:45957014 TESK2 0.44 5.58 0.32 5.79e-8 Red blood cell count;Reticulocyte count; CESC cis rs77106637 1.000 rs3862791 chr11:72501002 C/T cg04827223 chr11:72435913 ARAP1 -0.56 -5.77 -0.33 2.16e-8 Type 2 diabetes; CESC cis rs9682041 0.736 rs34237232 chr3:170063753 C/T cg11886554 chr3:170076028 SKIL -0.88 -7.67 -0.43 3.24e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg07256732 chr16:621771 PIGQ -0.29 -5.09 -0.3 6.74e-7 Height; CESC cis rs68170813 0.559 rs76020313 chr7:106877468 A/G cg02696742 chr7:106810147 HBP1 -0.52 -5.08 -0.3 7.2e-7 Coronary artery disease; CESC cis rs55871839 0.640 rs4738734 chr8:59814330 A/T cg07426533 chr8:59803705 TOX -0.48 -7.07 -0.4 1.41e-11 Pneumonia; CESC cis rs113835537 0.529 rs7950790 chr11:66258053 G/A cg24851651 chr11:66362959 CCS 0.44 5.46 0.32 1.09e-7 Airway imaging phenotypes; CESC cis rs1355223 1.000 rs1355223 chr11:34764479 A/G cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.1 -0.35 3.8e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7264396 0.635 rs6119672 chr20:34479767 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.59 7.17 0.4 7.61e-12 Total cholesterol levels; CESC cis rs10214930 0.697 rs757397 chr7:27908541 T/C cg05786569 chr7:27702416 HIBADH 0.44 5.23 0.31 3.39e-7 Hypospadias; CESC cis rs35110281 0.837 rs2838341 chr21:45076443 A/G cg01579765 chr21:45077557 HSF2BP -0.57 -9.74 -0.51 2.34e-19 Mean corpuscular volume; CESC cis rs897984 0.609 rs72800847 chr16:31022639 G/A cg02466173 chr16:30829666 NA -0.48 -7.62 -0.42 4.4e-13 Dementia with Lewy bodies; CESC cis rs854765 0.693 rs35451946 chr17:17764061 C/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.75 -0.38 9.22e-11 Total body bone mineral density; CESC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.43 -6.17 -0.35 2.58e-9 IgG glycosylation; CESC cis rs79349575 0.783 rs55771415 chr17:46999937 C/T cg16584676 chr17:46985605 UBE2Z 0.54 6.7 0.38 1.24e-10 Type 2 diabetes; CESC cis rs6674176 0.597 rs2352990 chr1:44393276 T/A cg12908607 chr1:44402522 ARTN -0.5 -7.24 -0.41 4.84e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg03188948 chr7:1209495 NA 0.72 6.98 0.39 2.42e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24616553 chr3:113557638 GRAMD1C 0.57 6.51 0.37 3.67e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6545883 0.929 rs7606167 chr2:61742654 C/G cg15711740 chr2:61764176 XPO1 -0.44 -5.4 -0.31 1.47e-7 Tuberculosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14158690 chr7:151826540 NA 0.5 6.23 0.36 1.82e-9 Fibrinogen levels; CESC trans rs10435719 0.871 rs7815186 chr8:11792062 C/G cg15556689 chr8:8085844 FLJ10661 0.52 6.39 0.37 7.33e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs734999 0.545 rs28532547 chr1:2561286 T/G cg20673091 chr1:2541236 MMEL1 -0.48 -8.01 -0.44 3.71e-14 Ulcerative colitis; CESC cis rs11229555 1.000 rs2275993 chr11:58379987 A/G cg15696309 chr11:58395628 NA -0.43 -5.64 -0.33 4.3e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs10791097 0.702 rs10894267 chr11:130714861 C/T cg12179176 chr11:130786555 SNX19 -0.56 -7.84 -0.43 1.09e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg08470875 chr2:26401718 FAM59B -0.48 -5.24 -0.31 3.31e-7 Gut microbiome composition (summer); CESC cis rs7100689 0.784 rs2153455 chr10:82139732 T/C cg00277334 chr10:82204260 NA -0.59 -7.5 -0.42 9.95e-13 Post bronchodilator FEV1; CESC cis rs9300255 0.510 rs1790086 chr12:123672518 A/G cg19016782 chr12:123741754 C12orf65 -0.42 -5.9 -0.34 1.09e-8 Neutrophil percentage of white cells; CESC cis rs763121 0.853 rs2064088 chr22:39053382 A/G cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.54e-7 Menopause (age at onset); CESC cis rs7666738 0.830 rs13144564 chr4:98939276 A/G cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7520050 0.807 rs6671802 chr1:46124663 A/G cg03146154 chr1:46216737 IPP 0.52 6.88 0.39 4.27e-11 Red blood cell count;Reticulocyte count; CESC cis rs1348850 0.574 rs2365617 chr2:178421934 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 5.51 0.32 8.52e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9527 0.590 rs2274339 chr10:104860053 T/A cg04362960 chr10:104952993 NT5C2 0.42 5.22 0.31 3.55e-7 Arsenic metabolism; CESC cis rs7551222 0.752 rs10793767 chr1:204549564 A/C cg20240347 chr1:204465584 NA -0.3 -5.98 -0.34 7.15e-9 Schizophrenia; CESC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg21951975 chr1:209979733 IRF6 -0.51 -8.62 -0.47 6.06e-16 Monobrow; CESC cis rs13191362 0.507 rs13207363 chr6:163201285 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.52 -6.14 -0.35 3.02e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2929278 0.589 rs2411284 chr15:44038899 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -7.81 -0.43 1.33e-13 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20034209 chr17:66287369 ARSG;SLC16A6 -0.48 -7.09 -0.4 1.2e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1832871 0.644 rs56180963 chr6:158773990 G/A cg07165851 chr6:158734300 TULP4 0.59 6.34 0.36 1.01e-9 Height; CESC cis rs798554 0.600 rs2679259 chr7:2885322 C/G cg13628971 chr7:2884303 GNA12 0.46 6.23 0.36 1.87e-9 Height; CESC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg14092988 chr3:52407081 DNAH1 0.43 5.5 0.32 9.09e-8 Bipolar disorder; CESC cis rs6570726 0.818 rs9390338 chr6:145908265 A/G cg23711669 chr6:146136114 FBXO30 0.92 13.58 0.64 3.16e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg14393609 chr7:65229607 NA -0.44 -5.76 -0.33 2.34e-8 Aortic root size; CESC cis rs3796352 1.000 rs13072395 chr3:52980573 T/C cg12962167 chr3:53033115 SFMBT1 0.67 5.28 0.31 2.73e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs6032067 0.852 rs17424751 chr20:43814622 T/C cg10761708 chr20:43804764 PI3 0.53 6.38 0.36 7.98e-10 Blood protein levels; CESC cis rs16854884 0.657 rs16854816 chr3:143734147 A/G cg06585982 chr3:143692056 C3orf58 0.5 6.56 0.37 2.84e-10 Economic and political preferences (feminism/equality); CESC cis rs8177179 0.904 rs1130459 chr3:133465283 A/G cg18769074 chr3:133464867 TF 0.3 5.75 0.33 2.42e-8 Iron status biomarkers (transferrin levels); CESC cis rs1355223 0.902 rs286858 chr11:34717357 T/C cg11058730 chr11:34937778 PDHX;APIP 0.49 6.73 0.38 1.03e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC trans rs7726839 0.561 rs72703044 chr5:579737 G/A cg25482853 chr8:67687455 SGK3 0.88 9.47 0.5 1.62e-18 Obesity-related traits; CESC cis rs9302635 0.550 rs35959677 chr16:72200801 G/T cg01557791 chr16:72042693 DHODH -0.62 -6.97 -0.39 2.5e-11 Blood protein levels; CESC cis rs11098499 0.821 rs10032151 chr4:120391628 C/T cg09307838 chr4:120376055 NA 0.94 13.94 0.65 1.68e-33 Corneal astigmatism; CESC trans rs1814175 0.645 rs28627251 chr11:50048125 G/T cg03929089 chr4:120376271 NA -0.92 -15.22 -0.68 5.15e-38 Height; CESC cis rs7552404 0.696 rs10518521 chr1:76461214 G/A cg03433033 chr1:76189801 ACADM 0.61 5.69 0.33 3.32e-8 Blood metabolite levels;Acylcarnitine levels; CESC trans rs55704346 0.566 rs9654100 chr4:25397695 G/T cg01822600 chr1:245751692 KIF26B 0.44 6.28 0.36 1.37e-9 Tonsillectomy; CESC trans rs9858542 0.953 rs1987628 chr3:49399259 G/A cg21659725 chr3:3221576 CRBN -0.55 -6.53 -0.37 3.38e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg20503657 chr10:835505 NA 0.78 7.74 0.43 2.08e-13 Eosinophil percentage of granulocytes; CESC cis rs60843830 1.000 rs55936726 chr2:258210 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.8 10.28 0.53 4.45e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs8070128 0.688 rs59304093 chr17:17875407 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.6 7.71 0.43 2.59e-13 Total body bone mineral density; CESC cis rs28489187 0.629 rs2012683 chr1:85841485 C/T cg16011679 chr1:85725395 C1orf52 0.48 5.7 0.33 3.21e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24035898 chr1:159825595 VSIG8;C1orf204 -0.59 -6.94 -0.39 3.06e-11 Gut microbiome composition (summer); CESC cis rs3892630 0.878 rs8108621 chr19:33183291 G/A cg13157960 chr19:33183277 NUDT19 0.57 5.61 0.33 5.17e-8 Red blood cell traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19816667 chr12:49741715 DNAJC22 0.57 6.33 0.36 1.06e-9 Gut microbiome composition (summer); CESC cis rs3857067 0.806 rs4560373 chr4:95113229 A/G cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.12 -0.49 1.97e-17 QT interval; CESC cis rs933688 1.000 rs35712350 chr5:90679519 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.13 14.91 0.68 6.31e-37 Smoking behavior; CESC cis rs68170813 0.641 rs61511581 chr7:106948091 T/A cg02696742 chr7:106810147 HBP1 -0.53 -5.19 -0.3 4.22e-7 Coronary artery disease; CESC cis rs9291683 0.588 rs3756236 chr4:10013463 T/A cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.7e-37 Bone mineral density; CESC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.47 -0.37 4.81e-10 Life satisfaction; CESC cis rs7746199 0.736 rs6904596 chr6:27491299 G/A cg18032046 chr6:28092343 ZSCAN16 -0.7 -5.03 -0.3 9.12e-7 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg24060327 chr5:131705240 SLC22A5 -0.41 -5.11 -0.3 6.13e-7 Breast cancer; CESC cis rs6460942 1.000 rs7792759 chr7:12311715 A/G cg02935154 chr7:12443704 VWDE 0.49 5.06 0.3 7.96e-7 Coronary artery disease; CESC cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg13877915 chr19:58951672 ZNF132 0.39 5.7 0.33 3.16e-8 Uric acid clearance; CESC cis rs17021463 0.872 rs34181160 chr4:95275157 T/G cg11021082 chr4:95130006 SMARCAD1 0.53 7.71 0.43 2.53e-13 Testicular germ cell tumor; CESC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs8141529 0.719 rs5762825 chr22:29223642 A/G cg15103426 chr22:29168792 CCDC117 0.68 9.65 0.51 4.52e-19 Lymphocyte counts; CESC cis rs12579753 0.879 rs11115009 chr12:82165409 G/T cg21193143 chr12:82153300 PPFIA2 0.34 5.07 0.3 7.44e-7 Resting heart rate; CESC cis rs7208859 0.673 rs423151 chr17:28952286 A/G cg14008862 chr17:28927542 LRRC37B2 0.71 6.45 0.37 5.31e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6570726 0.764 rs9386125 chr6:145911677 C/T cg05347473 chr6:146136440 FBXO30 0.57 7.44 0.42 1.37e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17208363 chr15:41851964 TYRO3 0.49 6.52 0.37 3.48e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7727544 0.716 rs7720230 chr5:131592405 T/G cg14196790 chr5:131705035 SLC22A5 0.37 5.49 0.32 9.54e-8 Blood metabolite levels; CESC cis rs1949733 0.543 rs62287446 chr4:8535988 G/A cg11789530 chr4:8429930 ACOX3 -0.53 -7.09 -0.4 1.23e-11 Response to antineoplastic agents; CESC cis rs3096299 0.900 rs4785666 chr16:89462771 C/G cg08392591 chr16:89556376 ANKRD11 0.41 5.28 0.31 2.68e-7 Multiple myeloma (IgH translocation); CESC cis rs2933343 0.621 rs789242 chr3:128585707 T/C cg25356066 chr3:128598488 ACAD9 0.56 7.83 0.43 1.15e-13 IgG glycosylation; CESC trans rs66573146 1.000 rs6838042 chr4:6973049 G/T cg07817883 chr1:32538562 TMEM39B 1.13 7.72 0.43 2.38e-13 Granulocyte percentage of myeloid white cells; CESC cis rs9596863 1.000 rs9568948 chr13:54437693 A/C ch.13.53330881F chr13:54432880 NA 0.62 5.09 0.3 6.83e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs10088262 0.629 rs6990565 chr8:124785645 C/A cg15047889 chr8:124780837 FAM91A1 -0.49 -6.0 -0.35 6.35e-9 Pancreatic cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18160291 chr1:210502147 HHAT 0.55 6.11 0.35 3.52e-9 Gut microbiome composition (summer); CESC cis rs9287719 0.967 rs963831 chr2:10745184 T/C cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC cis rs34638657 0.702 rs62044258 chr16:82199461 C/T cg09439754 chr16:82129088 HSD17B2 -0.37 -6.42 -0.37 6.31e-10 Lung adenocarcinoma; CESC cis rs3749237 0.636 rs1568662 chr3:49521263 A/G cg02487422 chr3:49467188 NICN1 0.57 8.3 0.45 5.33e-15 Resting heart rate; CESC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg22920501 chr2:26401640 FAM59B -0.65 -7.85 -0.43 1.06e-13 Gut microbiome composition (summer); CESC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg17221315 chr6:27791827 HIST1H4J 0.42 5.4 0.32 1.46e-7 Parkinson's disease; CESC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg05535760 chr7:792225 HEATR2 0.98 11.15 0.57 6.25e-24 Cerebrospinal P-tau181p levels; CESC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg15595755 chr5:1867978 NA 0.52 8.67 0.47 4.37e-16 Cardiovascular disease risk factors; CESC cis rs858239 0.570 rs6968242 chr7:23167411 T/G cg23682824 chr7:23144976 KLHL7 0.55 7.73 0.43 2.27e-13 Cerebrospinal fluid biomarker levels; CESC cis rs4803468 0.935 rs284660 chr19:41932084 G/T cg14132834 chr19:41945861 ATP5SL -0.59 -7.26 -0.41 4.34e-12 Height; CESC cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg11952622 chr19:58962976 ZNF324B 0.46 6.13 0.35 3.11e-9 Uric acid clearance; CESC cis rs11853189 0.938 rs77185764 chr15:78556076 G/A cg05392364 chr15:78556860 DNAJA4 0.64 5.15 0.3 5e-7 Red cell distribution width; CESC cis rs6570726 0.846 rs870491 chr6:145933390 T/G cg23711669 chr6:146136114 FBXO30 0.87 12.93 0.62 5.52e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs8038465 0.874 rs2291013 chr15:74000506 T/G cg15420318 chr15:73925796 NPTN 0.4 5.64 0.33 4.32e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg09323728 chr8:95962352 TP53INP1 -0.4 -8.97 -0.48 5.42e-17 Type 2 diabetes; CESC cis rs17666538 0.585 rs6559063 chr8:623051 C/T cg02524346 chr8:600233 NA 0.84 5.69 0.33 3.35e-8 IgG glycosylation; CESC cis rs6547741 1.000 rs1972669 chr2:27767107 T/G cg27432699 chr2:27873401 GPN1 0.49 6.94 0.39 2.93e-11 Oral cavity cancer; CESC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg02711726 chr17:80685570 FN3KRP -0.44 -5.85 -0.34 1.47e-8 Glycated hemoglobin levels; CESC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs2050392 1.000 rs2050392 chr10:30691503 G/A cg18806716 chr10:30721971 MAP3K8 -0.39 -5.54 -0.32 7.17e-8 Inflammatory bowel disease; CESC trans rs3942852 0.545 rs10838798 chr11:48091303 T/G cg15704280 chr7:45808275 SEPT13 -0.73 -9.53 -0.51 1.06e-18 Acute lymphoblastic leukemia (childhood); CESC cis rs1707322 0.686 rs11211179 chr1:46228082 A/C cg03146154 chr1:46216737 IPP 0.74 10.62 0.55 3.46e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg08704250 chr15:31115839 NA 0.63 8.88 0.48 1.02e-16 Huntington's disease progression; CESC cis rs10791097 0.642 rs7107568 chr11:130779668 T/C cg14779329 chr11:130786720 SNX19 0.41 6.42 0.37 6.3e-10 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg22590775 chr19:49891494 CCDC155 0.59 6.79 0.38 7.4e-11 Multiple sclerosis; CESC cis rs1005277 0.557 rs2983338 chr10:38550734 C/T cg25427524 chr10:38739819 LOC399744 -0.72 -10.62 -0.55 3.51e-22 Extrinsic epigenetic age acceleration; CESC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg15112475 chr7:1198522 ZFAND2A -0.39 -6.12 -0.35 3.4e-9 Longevity;Endometriosis; CESC cis rs2243480 1.000 rs316325 chr7:65609518 G/A cg12463550 chr7:65579703 CRCP 0.75 5.84 0.34 1.56e-8 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01174859 chr7:128379317 CALU 0.72 8.73 0.47 2.99e-16 Gut microbiome composition (summer); CESC cis rs2294693 0.945 rs742494 chr6:41007835 A/T cg14769373 chr6:40998127 UNC5CL -0.45 -5.72 -0.33 2.87e-8 Gastric cancer;Non-cardia gastric cancer; CESC trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg15704280 chr7:45808275 SEPT13 0.84 13.51 0.64 5.34e-32 Coronary artery disease; CESC cis rs9318086 0.578 rs75752641 chr13:24473240 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.44 6.31 0.36 1.19e-9 Myopia (pathological); CESC cis rs854765 0.647 rs712267 chr17:18021607 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.05 0.44 2.73e-14 Total body bone mineral density; CESC cis rs4332037 0.508 rs56758848 chr7:1868727 A/G cg13880726 chr7:1868755 MAD1L1 -0.52 -5.17 -0.3 4.67e-7 Bipolar disorder; CESC trans rs1973993 0.691 rs6658131 chr1:96889314 C/T cg10631902 chr5:14652156 NA 0.63 9.9 0.52 7.12e-20 Weight; CESC trans rs7246760 1.000 rs73507215 chr19:9887312 C/T cg02900749 chr2:68251473 NA -0.82 -7.08 -0.4 1.33e-11 Pursuit maintenance gain; CESC cis rs4077515 0.839 rs1132005 chr9:139296927 T/C cg14169450 chr9:139327907 INPP5E 0.36 5.07 0.3 7.55e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs2075371 0.863 rs1421479 chr7:133949345 T/G cg00033643 chr7:134001901 SLC35B4 0.4 5.14 0.3 5.46e-7 Mean platelet volume; CESC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg25072359 chr17:41440525 NA 0.48 6.54 0.37 3.13e-10 Menopause (age at onset); CESC cis rs10206020 0.797 rs72778008 chr2:1573182 T/G cg12573674 chr2:1569213 NA -0.48 -5.48 -0.32 9.85e-8 IgG glycosylation; CESC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg05368731 chr17:41323189 NBR1 0.79 11.18 0.57 4.95e-24 Menopause (age at onset); CESC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05048922 chr8:6565434 AGPAT5 0.5 6.33 0.36 1.03e-9 Gut microbiota (bacterial taxa); CESC cis rs1707322 0.752 rs11211147 chr1:46110094 A/G cg05343316 chr1:45956843 TESK2 0.5 6.18 0.35 2.46e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3091242 0.809 rs660129 chr1:25727438 C/T cg12412775 chr1:25698385 RHCE -0.32 -5.72 -0.33 2.92e-8 Erythrocyte sedimentation rate; CESC cis rs7095944 0.614 rs10901818 chr10:126449428 G/A cg08799069 chr10:126477246 METTL10 -0.35 -5.15 -0.3 5.19e-7 Asthma; CESC cis rs10464366 0.746 rs12674262 chr7:39141728 G/T cg18850127 chr7:39170497 POU6F2 0.37 5.09 0.3 6.76e-7 IgG glycosylation; CESC cis rs863345 0.967 rs11265025 chr1:158513286 T/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.45 -0.37 5.4e-10 Pneumococcal bacteremia; CESC cis rs7216064 0.589 rs8072723 chr17:66056970 T/A cg12091567 chr17:66097778 LOC651250 0.92 12.28 0.6 9.74e-28 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15716185 chr18:60190644 ZCCHC2 0.46 6.11 0.35 3.53e-9 Systemic lupus erythematosus; CESC cis rs9399137 0.507 rs4580893 chr6:135297662 G/A cg24558204 chr6:135376177 HBS1L 0.7 9.61 0.51 5.93e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22884899 chr17:6939299 SLC16A13 0.51 6.52 0.37 3.64e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs796364 0.806 rs10931889 chr2:201101900 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.78 -6.59 -0.38 2.33e-10 Schizophrenia; CESC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.43e-7 Life satisfaction; CESC trans rs7824557 0.527 rs2572369 chr8:11238597 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.17 -0.35 2.53e-9 Retinal vascular caliber; CESC trans rs3087243 0.755 rs3116514 chr2:204694784 G/A cg01841312 chr10:38069945 NA 0.38 6.33 0.36 1.03e-9 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs8017423 0.607 rs12885664 chr14:90845697 T/C cg14092571 chr14:90743983 NA 0.46 6.65 0.38 1.69e-10 Mortality in heart failure; CESC cis rs7618501 0.699 rs2777888 chr3:49898000 A/G cg24110177 chr3:50126178 RBM5 -0.45 -6.04 -0.35 5.06e-9 Intelligence (multi-trait analysis); CESC cis rs2832191 0.755 rs2832192 chr21:30491173 G/T cg08807101 chr21:30365312 RNF160 -0.67 -8.87 -0.48 1.12e-16 Dental caries; CESC cis rs6541297 1.000 rs6658942 chr1:230287517 A/C cg20703242 chr1:230279135 GALNT2 0.72 11.05 0.56 1.31e-23 Coronary artery disease; CESC cis rs7208859 0.623 rs3752021 chr17:29111043 G/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21144587 chr2:27851409 GPN1;CCDC121 -0.36 -6.23 -0.36 1.78e-9 Gambling; CESC cis rs7927592 0.763 rs11822059 chr11:68300822 T/G cg20283391 chr11:68216788 NA -0.41 -5.15 -0.3 5.18e-7 Total body bone mineral density; CESC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg02038168 chr22:39784481 NA -0.62 -7.71 -0.43 2.46e-13 Intelligence (multi-trait analysis); CESC cis rs2857078 0.654 rs4793083 chr17:42312973 C/T cg08499158 chr17:42289980 UBTF 0.45 5.48 0.32 9.98e-8 Red cell distribution width;Reticulocyte count; CESC trans rs1728785 1.000 rs1645979 chr16:68603660 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.7 8.22 0.45 9.15e-15 Ulcerative colitis; CESC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg11644478 chr21:40555479 PSMG1 -0.57 -7.9 -0.44 7.71e-14 Menarche (age at onset); CESC cis rs6835098 0.961 rs1574314 chr4:174106663 C/T cg08422745 chr4:174089978 GALNT7 -0.72 -9.42 -0.5 2.4e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.14 0.3 5.32e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22122680 chr1:220219742 EPRS 0.67 7.73 0.43 2.3e-13 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg16339924 chr4:17578868 LAP3 0.75 9.76 0.51 2.05e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8060686 0.545 rs7199878 chr16:68186301 A/G cg26727032 chr16:67993705 SLC12A4 -0.5 -5.45 -0.32 1.16e-7 HDL cholesterol;Metabolic syndrome; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg05896465 chr22:45560692 NUP50 -0.5 -6.6 -0.38 2.19e-10 Height; CESC cis rs9309473 1.000 rs9309473 chr2:73743982 A/G cg20560298 chr2:73613845 ALMS1 -0.53 -6.9 -0.39 3.82e-11 Metabolite levels; CESC cis rs4727963 0.846 rs12670195 chr7:122712925 T/G cg03640110 chr7:122635026 TAS2R16 0.38 5.87 0.34 1.28e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.76 7.92 0.44 6.53e-14 Mean platelet volume; CESC cis rs6460942 1.000 rs77010200 chr7:12290724 G/A cg02935154 chr7:12443704 VWDE -0.59 -5.79 -0.34 1.96e-8 Coronary artery disease; CESC cis rs807669 0.807 rs807431 chr22:19242361 G/A cg02655711 chr22:19163373 SLC25A1 0.54 8.02 0.44 3.48e-14 Metabolite levels; CESC cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 12.9 0.62 7.29e-30 Personality dimensions; CESC cis rs4253772 0.550 rs6007779 chr22:46678615 A/C cg09491104 chr22:46646882 C22orf40 -0.59 -8.78 -0.47 2e-16 LDL cholesterol;Cholesterol, total; CESC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg10053473 chr17:62856997 LRRC37A3 0.67 7.42 0.41 1.61e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg03647317 chr4:187891568 NA -0.41 -5.91 -0.34 1.02e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1008375 1.000 rs7654345 chr4:17691796 A/G cg02297831 chr4:17616191 MED28 0.5 5.95 0.34 8.38e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 5.97 0.34 7.58e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7940866 0.845 rs10894294 chr11:130830748 G/T cg12179176 chr11:130786555 SNX19 0.59 8.03 0.44 3.21e-14 Schizophrenia; CESC cis rs4835473 0.864 rs2089837 chr4:144886191 G/A cg25736465 chr4:144833511 NA 0.41 6.25 0.36 1.64e-9 Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24834479 chr5:133702818 CDKL3 0.58 6.11 0.35 3.58e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.03 0.3 9.07e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg18301423 chr5:131593218 PDLIM4 0.37 5.36 0.31 1.78e-7 Breast cancer; CESC cis rs1348850 0.914 rs6710575 chr2:178377311 C/T cg23306229 chr2:178417860 TTC30B 0.63 7.8 0.43 1.41e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10242455 0.867 rs2404770 chr7:99321612 A/G cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg12311346 chr5:56204834 C5orf35 0.64 8.64 0.47 5.57e-16 Initial pursuit acceleration; CESC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg25072359 chr17:41440525 NA 0.46 6.1 0.35 3.77e-9 Menopause (age at onset); CESC cis rs2952156 0.920 rs12940986 chr17:37836581 A/G cg20243544 chr17:37824526 PNMT -0.61 -8.21 -0.45 1.01e-14 Asthma; CESC cis rs2228479 0.850 rs11644804 chr16:89976224 G/A cg06558623 chr16:89946397 TCF25 0.79 6.96 0.39 2.68e-11 Skin colour saturation; CESC trans rs12542260 0.817 rs117952028 chr8:125471390 C/A cg09438698 chr12:133365205 GOLGA3 -0.51 -6.56 -0.37 2.75e-10 Colonoscopy-negative controls vs population controls; CESC cis rs5758659 0.714 rs5751220 chr22:42516205 A/C cg00645731 chr22:42541494 CYP2D7P1 0.33 5.62 0.33 4.75e-8 Cognitive function; CESC cis rs4812048 1.000 rs6070696 chr20:57597645 A/G cg14073986 chr20:57617431 SLMO2 0.61 5.94 0.34 8.75e-9 Mean platelet volume; CESC cis rs7267979 0.966 rs8123949 chr20:25388133 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.03 -0.74 5.81e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs11098499 0.954 rs4345162 chr4:120312959 G/A cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs4664308 0.618 rs3749117 chr2:160885442 T/C cg03641300 chr2:160917029 PLA2R1 -0.54 -7.62 -0.42 4.63e-13 Idiopathic membranous nephropathy; CESC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg03609598 chr5:56110824 MAP3K1 0.49 5.17 0.3 4.71e-7 Initial pursuit acceleration; CESC cis rs7617480 0.648 rs6796790 chr3:48780317 G/A cg06212747 chr3:49208901 KLHDC8B 0.48 5.91 0.34 1.05e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 11.52 0.58 3.59e-25 Platelet count; CESC trans rs6951245 0.554 rs11761322 chr7:1151657 A/G cg13565492 chr6:43139072 SRF -0.75 -9.1 -0.49 2.18e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg17385448 chr1:15911702 AGMAT 0.42 6.82 0.39 6.1e-11 Systolic blood pressure; CESC cis rs123509 0.913 rs339661 chr3:42753904 G/A cg12982090 chr3:42733453 KBTBD5 0.72 8.9 0.48 9.29e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4664304 0.772 rs6737904 chr2:160872526 G/C cg03641300 chr2:160917029 PLA2R1 -0.5 -7.01 -0.4 1.97e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg11890956 chr21:40555474 PSMG1 1.11 17.84 0.74 2.65e-47 Cognitive function; CESC cis rs10089 1.000 rs10089 chr5:127522543 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 9.53 0.51 1.07e-18 Ileal carcinoids; CESC cis rs3106136 0.527 rs10030586 chr4:95150805 A/C cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Capecitabine sensitivity; CESC cis rs317689 0.690 rs618470 chr12:69672060 A/G cg20891283 chr12:69753455 YEATS4 0.48 5.19 0.3 4.16e-7 Response to diuretic therapy; CESC cis rs9911578 1.000 rs6503870 chr17:56659018 C/T cg12560992 chr17:57184187 TRIM37 0.93 15.48 0.69 6.05e-39 Intelligence (multi-trait analysis); CESC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg05255149 chr17:80675120 FN3KRP -0.45 -5.27 -0.31 2.78e-7 Breast cancer; CESC cis rs4891159 0.548 rs690082 chr18:74116668 C/T cg24786174 chr18:74118243 ZNF516 0.85 16.07 0.7 4.75e-41 Longevity; CESC cis rs9326248 0.530 rs2155583 chr11:116915217 A/G cg01368799 chr11:117014884 PAFAH1B2 0.6 5.43 0.32 1.28e-7 Blood protein levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05142592 chr10:135097800 TUBGCP2 -0.42 -7.43 -0.42 1.51e-12 Gambling; CESC cis rs9863 0.827 rs12823740 chr12:124458002 C/A cg00084347 chr12:124393913 DNAH10 0.27 5.13 0.3 5.59e-7 White blood cell count; CESC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg09197432 chr4:183729176 NA 0.58 6.17 0.35 2.54e-9 Pediatric autoimmune diseases; CESC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg22143856 chr6:28129313 ZNF389 0.46 5.84 0.34 1.56e-8 Depression; CESC cis rs9611565 0.729 rs137831 chr22:41903813 A/C cg17376030 chr22:41985996 PMM1 0.49 5.83 0.34 1.58e-8 Vitiligo; CESC cis rs4835473 0.864 rs2323418 chr4:144890294 C/T cg25736465 chr4:144833511 NA 0.41 6.25 0.36 1.66e-9 Immature fraction of reticulocytes; CESC cis rs7824557 0.767 rs1897951 chr8:11169854 C/T cg21775007 chr8:11205619 TDH 0.47 6.95 0.39 2.85e-11 Retinal vascular caliber; CESC cis rs3126085 0.935 rs10888468 chr1:152181539 C/T cg03465714 chr1:152285911 FLG -0.43 -5.16 -0.3 4.81e-7 Atopic dermatitis; CESC cis rs11696845 0.666 rs13042905 chr20:43379454 T/C cg25301532 chr20:43378953 KCNK15 0.38 6.08 0.35 4.26e-9 Obesity-related traits; CESC cis rs67311347 1.000 rs7648952 chr3:40457038 C/T cg24209194 chr3:40518798 ZNF619 -0.43 -5.71 -0.33 3.04e-8 Renal cell carcinoma; CESC cis rs8040855 0.627 rs3816105 chr15:85640911 G/A cg08123816 chr15:85640762 PDE8A -0.41 -6.16 -0.35 2.7e-9 Bulimia nervosa; CESC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg00166722 chr3:10149974 C3orf24 0.49 6.27 0.36 1.44e-9 Alzheimer's disease; CESC cis rs7511006 0.893 rs2038049 chr22:50654888 G/C cg07895657 chr22:50616420 PANX2 -0.37 -5.62 -0.33 4.76e-8 Obesity-related traits; CESC cis rs920590 0.684 rs3899017 chr8:19669198 A/T cg01411142 chr8:19674711 INTS10 0.56 6.19 0.36 2.27e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -10.0 -0.52 3.4e-20 Extrinsic epigenetic age acceleration; CESC cis rs4474465 0.688 rs7940507 chr11:78284453 T/C cg27205649 chr11:78285834 NARS2 0.51 6.91 0.39 3.54e-11 Alzheimer's disease (survival time); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20762182 chr15:69727293 KIF23 0.52 7.2 0.4 6.03e-12 Fibrinogen levels; CESC cis rs9660992 0.573 rs12140422 chr1:205187981 G/A cg21643547 chr1:205240462 TMCC2 -0.39 -5.56 -0.32 6.46e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg26939375 chr7:64535504 NA 0.76 10.87 0.56 5.31e-23 Calcium levels; CESC cis rs9303280 0.806 rs36038753 chr17:38035370 G/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.42 -0.32 1.31e-7 Self-reported allergy; CESC trans rs17808461 1.000 rs1468197 chr17:31372945 C/T cg01914314 chr5:157117640 NA 0.51 6.22 0.36 1.98e-9 Obesity-related traits; CESC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.72 0.62 2.88e-29 Alzheimer's disease; CESC cis rs1348850 0.539 rs1453371 chr2:178227862 T/G cg22681709 chr2:178499509 PDE11A -0.37 -5.36 -0.31 1.79e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10823500 0.549 rs10999204 chr10:72007306 G/A cg02100629 chr10:71892760 AIFM2 -0.32 -5.32 -0.31 2.23e-7 Blood protein levels; CESC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg25036284 chr2:26402008 FAM59B 0.79 8.65 0.47 5e-16 Gut microbiome composition (summer); CESC cis rs6032067 0.929 rs17333555 chr20:43809761 C/T cg10761708 chr20:43804764 PI3 0.52 6.27 0.36 1.45e-9 Blood protein levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg21192376 chr14:53020168 GPR137C;TXNDC16 0.49 6.33 0.36 1.05e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs76419734 0.510 rs2553461 chr4:106731410 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.62 -6.36 -0.36 8.88e-10 Post bronchodilator FEV1; CESC cis rs12912251 1.000 rs12903120 chr15:38988097 G/T cg01338139 chr15:38987640 C15orf53 -0.47 -5.43 -0.32 1.26e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg21454386 chr13:114292018 TFDP1 0.47 6.0 0.35 6.34e-9 Recombination measurement; CESC trans rs2733310 0.739 rs72747165 chr15:57147334 G/A cg13494055 chr3:59115467 NA -0.43 -5.99 -0.35 6.64e-9 Mean platelet volume; CESC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.22 -0.41 5.62e-12 Total body bone mineral density; CESC cis rs2842992 0.830 rs1535475 chr6:160148935 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.74 9.33 0.5 4.52e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs12711979 0.509 rs13035992 chr2:3826597 G/A cg17052675 chr2:3827356 NA -0.67 -11.26 -0.57 2.77e-24 Itch intensity from mosquito bite adjusted by bite size; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21701354 chr7:129592850 UBE2H -0.45 -6.16 -0.35 2.7e-9 Ulcerative colitis; CESC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.82 -9.06 -0.49 2.95e-17 Gut microbiome composition (summer); CESC cis rs2933343 0.621 rs789249 chr3:128578453 T/C cg25356066 chr3:128598488 ACAD9 0.6 8.53 0.46 1.17e-15 IgG glycosylation; CESC cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg21918786 chr6:109611834 NA -0.4 -5.99 -0.35 6.87e-9 Reticulocyte fraction of red cells; CESC cis rs11153306 0.765 rs7740180 chr6:111944538 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.4 -6.09 -0.35 3.87e-9 Tonsillectomy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00920043 chr1:11333412 UBIAD1 -0.44 -6.72 -0.38 1.14e-10 Gambling; CESC cis rs6582630 0.638 rs12231073 chr12:38526901 T/G cg26384229 chr12:38710491 ALG10B -0.42 -5.59 -0.32 5.66e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs3213545 0.659 rs2259690 chr12:121457914 T/G cg15155738 chr12:121454335 C12orf43 0.5 6.07 0.35 4.35e-9 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg18876405 chr7:65276391 NA 0.69 9.67 0.51 3.96e-19 Calcium levels; CESC cis rs7020830 0.830 rs13296413 chr9:37258105 C/T cg14294708 chr9:37120828 ZCCHC7 1.2 22.49 0.81 2.13e-63 Schizophrenia; CESC cis rs7223966 1.000 rs15637 chr17:61772050 C/G cg11494091 chr17:61959527 GH2 0.38 5.42 0.32 1.33e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2952156 0.920 rs732083 chr17:37834367 G/A cg00129232 chr17:37814104 STARD3 -0.77 -11.37 -0.57 1.13e-24 Asthma; CESC cis rs7786808 0.707 rs62479983 chr7:158227613 G/A cg01191920 chr7:158217561 PTPRN2 -0.44 -7.74 -0.43 2.13e-13 Obesity-related traits; CESC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg11494091 chr17:61959527 GH2 0.73 12.66 0.61 4.86e-29 Prudent dietary pattern; CESC cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6728642 0.901 rs7584641 chr2:97607655 A/T cg26665480 chr2:98280029 ACTR1B -0.53 -5.38 -0.31 1.66e-7 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs12477438 0.748 rs7558239 chr2:99640581 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg24578937 chr1:2090814 PRKCZ -0.35 -6.01 -0.35 5.96e-9 Height; CESC cis rs7084402 0.967 rs1427224 chr10:60290620 G/A cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs79349575 0.783 rs55771415 chr17:46999937 C/T cg26022315 chr17:47021804 SNF8 0.39 5.18 0.3 4.5e-7 Type 2 diabetes; CESC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3733585 0.781 rs6449183 chr4:9970691 C/A cg02734326 chr4:10020555 SLC2A9 -0.46 -6.74 -0.38 9.94e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6912958 0.712 rs7772561 chr6:88331299 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.76 -0.38 8.85e-11 Monocyte percentage of white cells; CESC cis rs2243480 1.000 rs6964530 chr7:65718851 G/C cg13147721 chr7:65941812 NA 0.94 8.82 0.48 1.55e-16 Diabetic kidney disease; CESC cis rs10979 1.000 rs6570566 chr6:143899534 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.03 -0.48 3.7e-17 Hypospadias; CESC cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.46 7.69 0.43 2.8e-13 Monocyte percentage of white cells; CESC cis rs9902453 0.765 rs62068653 chr17:28212663 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 8.58 0.47 8.08e-16 Coffee consumption (cups per day); CESC cis rs34311866 0.808 rs11248060 chr4:964359 C/T cg07828340 chr4:882639 GAK 0.86 6.95 0.39 2.9e-11 Parkinson's disease; CESC cis rs2235642 0.893 rs2076445 chr16:1592266 A/T cg08296037 chr16:1584118 IFT140;TMEM204 -0.34 -5.56 -0.32 6.55e-8 Coronary artery disease; CESC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10818894 0.571 rs4838069 chr9:126316511 C/T cg16191174 chr9:126692580 DENND1A 0.5 5.71 0.33 3e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); CESC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.74 -0.33 2.55e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg25036284 chr2:26402008 FAM59B -0.59 -6.88 -0.39 4.37e-11 Gut microbiome composition (summer); CESC trans rs4129059 0.765 rs58247568 chr1:214711855 G/A cg08821431 chr12:34491090 NA 0.55 6.16 0.35 2.75e-9 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00060500 chr3:197476529 KIAA0226;FYTTD1 0.52 6.04 0.35 5.2e-9 Gut microbiome composition (summer); CESC cis rs4588572 0.686 rs4703756 chr5:77683490 T/C cg11547950 chr5:77652471 NA 0.46 5.94 0.34 8.76e-9 Triglycerides; CESC cis rs858239 0.601 rs929508 chr7:23166709 C/A cg23682824 chr7:23144976 KLHL7 0.54 7.61 0.42 4.95e-13 Cerebrospinal fluid biomarker levels; CESC cis rs3793683 0.545 rs12784446 chr10:134589094 T/G cg27297192 chr10:134578999 INPP5A 0.4 5.42 0.32 1.34e-7 Migraine; CESC cis rs17125944 0.686 rs73304351 chr14:53375140 G/A cg00686598 chr14:53173677 PSMC6 0.97 7.16 0.4 8.16e-12 Alzheimer's disease (late onset); CESC cis rs16937 0.711 rs12142514 chr1:205122529 A/G cg00857998 chr1:205179979 DSTYK 0.4 5.23 0.31 3.43e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03252697 chr11:65623186 CFL1 -0.6 -6.96 -0.39 2.73e-11 Gut microbiome composition (summer); CESC trans rs7307889 1.000 rs73052336 chr12:5982664 G/T cg18407955 chr7:158110685 PTPRN2 -0.72 -6.02 -0.35 5.71e-9 Obesity-related traits; CESC cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg05481257 chr2:20870211 GDF7 0.37 6.18 0.35 2.4e-9 Abdominal aortic aneurysm; CESC cis rs10024216 0.559 rs115820155 chr4:38772730 G/T cg02016764 chr4:38805732 TLR1 -0.33 -5.16 -0.3 4.93e-7 Systemic sclerosis (anti-topoisomerase-positive); CESC cis rs7666738 0.830 rs7672127 chr4:98938477 A/G cg05340658 chr4:99064831 C4orf37 0.83 12.56 0.61 1.05e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs12048904 0.930 rs11166529 chr1:101333733 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.58 7.55 0.42 6.82e-13 Multiple sclerosis; CESC trans rs1373453 0.808 rs17106957 chr12:70075022 A/G cg19702771 chr4:82058885 PRKG2 0.76 6.08 0.35 4.2e-9 Orofacial clefts; CESC cis rs1348850 0.750 rs13031008 chr2:178477114 G/A cg22681709 chr2:178499509 PDE11A -0.42 -6.27 -0.36 1.43e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs763014 0.931 rs2071981 chr16:630025 C/G cg07343612 chr16:622815 PIGQ -0.58 -8.49 -0.46 1.53e-15 Height; CESC cis rs7607369 0.536 rs7566656 chr2:219664519 A/G cg02176678 chr2:219576539 TTLL4 -0.36 -6.39 -0.37 7.24e-10 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs9815354 0.812 rs73073352 chr3:41842184 T/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs10189230 0.967 rs13026380 chr2:222352715 G/A cg14652038 chr2:222343519 EPHA4 0.37 7.76 0.43 1.85e-13 Urate levels in lean individuals; CESC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg05332525 chr7:65337924 VKORC1L1 0.51 6.38 0.36 7.81e-10 Calcium levels; CESC cis rs826838 0.967 rs73096706 chr12:38860563 G/A cg13010199 chr12:38710504 ALG10B 0.6 8.39 0.46 2.99e-15 Heart rate; CESC cis rs4689388 0.853 rs6817447 chr4:6286847 G/T cg14416269 chr4:6271139 WFS1 0.48 8.2 0.45 1.02e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg06873352 chr17:61820015 STRADA 0.45 6.73 0.38 1.04e-10 Height; CESC cis rs9926296 0.744 rs154657 chr16:89708096 A/G cg03605463 chr16:89740564 NA -0.64 -7.84 -0.43 1.09e-13 Vitiligo; CESC trans rs3784262 0.669 rs12909423 chr15:58292433 C/G cg20199333 chr11:46740790 F2 0.38 6.11 0.35 3.55e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs7216064 0.953 rs10445361 chr17:65962238 G/T cg12091567 chr17:66097778 LOC651250 0.73 8.0 0.44 3.87e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs3820928 0.874 rs4423583 chr2:227874957 A/G cg05526886 chr2:227700861 RHBDD1 0.44 5.47 0.32 1.05e-7 Pulmonary function; CESC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg10691866 chr7:65817282 TPST1 0.33 5.16 0.3 4.76e-7 Aortic root size; CESC cis rs9902453 0.817 rs17226179 chr17:28168573 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 8.45 0.46 2.01e-15 Coffee consumption (cups per day); CESC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg22433210 chr17:43662623 NA 0.62 8.06 0.44 2.71e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4237845 0.537 rs7312623 chr12:58262523 G/T cg00677455 chr12:58241039 CTDSP2 0.78 10.45 0.54 1.24e-21 Intelligence (multi-trait analysis); CESC cis rs8002861 0.905 rs11617551 chr13:44443977 T/C cg19180546 chr13:44453867 C13orf31;CCDC122 -0.42 -5.36 -0.31 1.79e-7 Leprosy; CESC cis rs9875589 0.957 rs13077668 chr3:13929756 A/G cg19554555 chr3:13937349 NA -0.54 -7.19 -0.4 6.82e-12 Ovarian reserve; CESC trans rs945270 0.512 rs868199 chr14:56195994 A/T cg18102697 chr4:83542773 C4orf11 -0.43 -6.55 -0.37 3.06e-10 Subcortical brain region volumes; CESC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg23758822 chr17:41437982 NA -1.02 -17.62 -0.73 1.65e-46 Menopause (age at onset); CESC cis rs7917772 0.508 rs2252147 chr10:104467774 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.51 5.78 0.33 2.1e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs60154123 0.505 rs7540237 chr1:210053325 C/T cg23283495 chr1:209979779 IRF6 0.52 5.52 0.32 8.02e-8 Coronary artery disease; CESC cis rs11958404 0.932 rs111802867 chr5:157424971 G/A cg05962755 chr5:157440814 NA 0.6 6.38 0.36 8e-10 IgG glycosylation; CESC cis rs477692 0.905 rs563859 chr10:131417586 T/C cg05714579 chr10:131428358 MGMT 0.54 7.64 0.42 4.09e-13 Response to temozolomide; CESC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.83 0.39 5.8200000000000003e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2066819 0.892 rs77415512 chr12:56627300 A/G cg26734620 chr12:56694298 CS 1.04 6.26 0.36 1.51e-9 Psoriasis vulgaris; CESC cis rs2777491 0.957 rs7163788 chr15:41704789 A/G cg02330683 chr15:41787940 ITPKA 0.48 7.12 0.4 1.02e-11 Ulcerative colitis; CESC cis rs3096299 0.967 rs28644774 chr16:89472181 G/C cg02187348 chr16:89574699 SPG7 0.52 7.0 0.39 2.14e-11 Multiple myeloma (IgH translocation); CESC cis rs8020095 0.571 rs6573734 chr14:67366929 A/T cg19548862 chr14:67692701 FAM71D -0.48 -5.76 -0.33 2.34e-8 Depression (quantitative trait); CESC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg11766577 chr21:47581405 C21orf56 -0.48 -6.5 -0.37 3.99e-10 Testicular germ cell tumor; CESC cis rs9926296 0.609 rs4785710 chr16:89796756 C/T cg27121462 chr16:89883253 FANCA -0.63 -8.01 -0.44 3.7e-14 Vitiligo; CESC cis rs6732160 0.932 rs768851 chr2:73378241 G/A cg01422370 chr2:73384389 NA 0.5 8.59 0.47 7.75e-16 Intelligence (multi-trait analysis); CESC trans rs2727020 0.567 rs1164687 chr11:49290669 G/A cg15704280 chr7:45808275 SEPT13 0.8 11.17 0.57 5.5e-24 Coronary artery disease; CESC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.33 0.31 2.11e-7 Tonsillectomy; CESC trans rs561341 0.882 rs563539 chr17:30307958 A/G cg27661571 chr11:113659931 NA -0.69 -7.04 -0.4 1.6e-11 Hip circumference adjusted for BMI; CESC cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg00745463 chr17:30367425 LRRC37B -0.83 -7.54 -0.42 7.69e-13 Hip circumference adjusted for BMI; CESC cis rs116095464 0.558 rs7714335 chr5:263513 T/C cg22496380 chr5:211416 CCDC127 -0.74 -7.84 -0.43 1.1e-13 Breast cancer; CESC cis rs3796352 1.000 rs59583591 chr3:53119581 T/C cg26060971 chr3:52407402 DNAH1 -0.44 -5.15 -0.3 4.99e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs9790314 0.875 rs7615592 chr3:160981548 A/C cg04691961 chr3:161091175 C3orf57 -0.41 -5.22 -0.31 3.65e-7 Morning vs. evening chronotype; CESC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.43 0.54 1.5e-21 Prudent dietary pattern; CESC cis rs9487051 0.752 rs9372209 chr6:109601684 T/C cg21918786 chr6:109611834 NA -0.37 -5.39 -0.31 1.55e-7 Reticulocyte fraction of red cells; CESC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg13012494 chr21:47604986 C21orf56 0.5 6.78 0.38 7.7e-11 Testicular germ cell tumor; CESC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg22433210 chr17:43662623 NA -0.91 -10.81 -0.55 8.16e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC cis rs4820539 1.000 rs2267003 chr22:23457098 A/G cg14186256 chr22:23484241 RTDR1 0.82 14.3 0.66 9.35e-35 Bone mineral density; CESC cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg06784218 chr1:46089804 CCDC17 -0.3 -5.11 -0.3 6.3e-7 High light scatter reticulocyte count; CESC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.13 -0.35 3.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8014204 0.781 rs10143492 chr14:75212114 G/C cg08847533 chr14:75593920 NEK9 0.42 5.34 0.31 2.02e-7 Caffeine consumption; CESC cis rs9902453 0.817 rs9909128 chr17:28161482 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.78 10.19 0.53 8.43e-21 Coffee consumption (cups per day); CESC cis rs8114671 0.562 rs8117491 chr20:33510120 T/C cg07148914 chr20:33460835 GGT7 0.52 6.8 0.39 6.88e-11 Height; CESC cis rs6912958 1.000 rs13214153 chr6:88153983 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.16 -0.3 4.87e-7 Monocyte percentage of white cells; CESC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg23172400 chr8:95962367 TP53INP1 -0.42 -8.57 -0.47 8.93e-16 Type 2 diabetes; CESC cis rs9858542 0.953 rs9878943 chr3:49434654 G/A cg07274523 chr3:49395745 GPX1 0.68 8.44 0.46 2.17e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.44 0.5 2.01e-18 Menopause (age at onset); CESC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 11.54 0.58 3.09e-25 Personality dimensions; CESC cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg02487422 chr3:49467188 NICN1 0.46 5.81 0.34 1.82e-8 Parkinson's disease; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg08265551 chr1:151032119 CDC42SE1;MLLT11 0.45 6.32 0.36 1.08e-9 Breast cancer;Type 2 diabetes; CESC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg18230493 chr5:56204884 C5orf35 -0.68 -8.18 -0.45 1.2e-14 Initial pursuit acceleration; CESC cis rs6963495 0.745 rs68153235 chr7:105184832 A/C cg19920283 chr7:105172520 RINT1 0.72 8.19 0.45 1.1e-14 Bipolar disorder (body mass index interaction); CESC cis rs13382862 0.823 rs12710743 chr2:20880714 T/C cg10553204 chr2:20871195 GDF7 -0.37 -5.2 -0.3 4.04e-7 Abdominal aortic aneurysm; CESC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg18402987 chr7:1209562 NA 0.77 7.88 0.44 8.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg14820908 chr5:178986412 RUFY1 0.44 6.16 0.35 2.69e-9 Lung cancer; CESC cis rs67478160 0.643 rs12891175 chr14:104274166 T/C cg08213375 chr14:104286397 PPP1R13B 0.54 10.76 0.55 1.22e-22 Schizophrenia; CESC cis rs4835473 0.932 rs1849112 chr4:144883655 T/C cg25736465 chr4:144833511 NA 0.39 5.64 0.33 4.34e-8 Immature fraction of reticulocytes; CESC cis rs11690935 0.550 rs62183801 chr2:172867475 G/A cg13550731 chr2:172543902 DYNC1I2 0.49 6.75 0.38 9.18e-11 Schizophrenia; CESC trans rs6570726 0.846 rs372904 chr6:145887425 T/C cg03826317 chr10:25465503 LOC100128811;GPR158 0.31 6.15 0.35 2.82e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs796364 0.806 rs78527234 chr2:200913453 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs7555523 0.943 rs4537525 chr1:165711089 T/G cg24409356 chr1:165738333 TMCO1 0.97 8.67 0.47 4.48e-16 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs1878931 0.501 rs9635547 chr16:3416664 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.74 9.7 0.51 3.16e-19 Body mass index (adult); CESC trans rs1814175 0.645 rs1608632 chr11:49967148 C/T cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg16049864 chr8:95962084 TP53INP1 -0.63 -10.11 -0.53 1.51e-20 Type 2 diabetes; CESC cis rs17376456 0.569 rs2924374 chr5:93151141 T/C cg25358565 chr5:93447407 FAM172A -0.7 -7.37 -0.41 2.17e-12 Diabetic retinopathy; CESC trans rs6089829 0.925 rs3746748 chr20:61667526 C/T cg23505145 chr19:12996616 KLF1 0.51 6.68 0.38 1.37e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg09877947 chr5:131593287 PDLIM4 0.45 5.47 0.32 1.02e-7 Acylcarnitine levels; CESC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.14 -0.53 1.22e-20 Alzheimer's disease; CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg18402987 chr7:1209562 NA 0.43 5.62 0.33 4.86e-8 Longevity;Endometriosis; CESC cis rs11098499 0.954 rs28685688 chr4:120420334 T/C cg09307838 chr4:120376055 NA 0.93 12.93 0.62 5.46e-30 Corneal astigmatism; CESC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.7 7.51 0.42 9.29e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7527798 0.637 rs7515149 chr1:207838352 T/G cg21110645 chr1:207815933 NA -0.34 -5.84 -0.34 1.55e-8 Erythrocyte sedimentation rate; CESC trans rs561341 0.714 rs75861674 chr17:30304317 A/G cg27661571 chr11:113659931 NA -0.71 -7.4 -0.41 1.78e-12 Hip circumference adjusted for BMI; CESC cis rs13095912 0.778 rs7651346 chr3:185300395 G/A cg11274856 chr3:185301563 NA 0.38 5.69 0.33 3.35e-8 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12477533 chr2:98703450 VWA3B 0.57 6.07 0.35 4.3e-9 Gut microbiome composition (summer); CESC cis rs6598955 0.671 rs11247909 chr1:26640135 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.36 5.19 0.3 4.09e-7 Obesity-related traits; CESC cis rs4654899 1.000 rs10799686 chr1:21486445 A/T cg05370193 chr1:21551575 ECE1 -0.39 -5.77 -0.33 2.19e-8 Superior frontal gyrus grey matter volume; CESC cis rs7833790 0.654 rs7835342 chr8:82698092 A/G cg17211192 chr8:82754475 SNX16 -0.58 -7.62 -0.42 4.64e-13 Diastolic blood pressure; CESC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7789940 1.000 rs73140069 chr7:75986790 T/A cg10167463 chr7:75959203 YWHAG -0.56 -7.09 -0.4 1.23e-11 Multiple sclerosis; CESC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg16325326 chr1:53192061 ZYG11B 0.83 14.04 0.65 7.5e-34 Monocyte count; CESC cis rs6142102 0.517 rs6059577 chr20:32527686 T/C cg08999081 chr20:33150536 PIGU 0.35 5.26 0.31 3.03e-7 Skin pigmentation; CESC cis rs1580019 0.563 rs13244332 chr7:32537679 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.45 0.37 5.2400000000000005e-10 Cognitive ability; CESC cis rs10927875 0.632 rs2862162 chr1:16142960 A/C cg18973939 chr1:16164122 FLJ37453 -0.38 -5.72 -0.33 2.84e-8 Dilated cardiomyopathy; CESC cis rs7116495 0.609 rs73531955 chr11:71687794 A/C cg10381502 chr11:71823885 C11orf51 1.19 7.71 0.43 2.49e-13 Severe influenza A (H1N1) infection; CESC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg16132339 chr22:24313637 DDTL;DDT 0.35 5.26 0.31 2.96e-7 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg18305652 chr10:134549665 INPP5A 0.48 6.75 0.38 9.22e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg10523679 chr1:76189770 ACADM 0.74 9.81 0.52 1.37e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg15664640 chr17:80829946 TBCD 0.5 6.95 0.39 2.81e-11 Breast cancer; CESC cis rs9916302 0.904 rs2061338 chr17:37421767 T/C cg00129232 chr17:37814104 STARD3 -0.53 -6.89 -0.39 4.12e-11 Glomerular filtration rate (creatinine); CESC trans rs7615952 0.673 rs35955861 chr3:125626201 T/C cg07211511 chr3:129823064 LOC729375 -0.87 -8.14 -0.45 1.59e-14 Blood pressure (smoking interaction); CESC cis rs7586879 0.616 rs13410999 chr2:25097939 T/C cg01884057 chr2:25150051 NA 0.38 7.4 0.41 1.85e-12 Body mass index; CESC cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg24308560 chr3:49941425 MST1R 0.58 8.41 0.46 2.58e-15 Body mass index; CESC cis rs4547160 0.781 rs12228037 chr12:63484560 C/T cg26727693 chr12:63544175 AVPR1A 0.35 5.3 0.31 2.46e-7 Morning vs. evening chronotype; CESC cis rs72792276 1.000 rs72792279 chr5:127374404 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.68 5.24 0.31 3.26e-7 Red cell distribution width; CESC cis rs2130392 0.926 rs4610379 chr4:185624388 A/G cg21366198 chr4:185655624 MLF1IP -0.47 -6.89 -0.39 3.95e-11 Kawasaki disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13131263 chr1:9324393 H6PD 0.47 6.19 0.36 2.33e-9 Fibrinogen levels; CESC cis rs959260 1.000 rs9902966 chr17:73362147 C/T cg12999837 chr17:73267436 MIF4GD -0.47 -5.36 -0.31 1.78e-7 Systemic lupus erythematosus; CESC cis rs2797160 1.000 rs2747720 chr6:126009458 A/G cg05901451 chr6:126070800 HEY2 0.45 6.59 0.38 2.39e-10 Endometrial cancer; CESC cis rs7115242 0.720 rs10790169 chr11:116877159 A/C cg01368799 chr11:117014884 PAFAH1B2 0.59 5.44 0.32 1.2e-7 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.57 0.37 2.71e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26322913 chr14:50999702 MAP4K5;ATL1 0.55 6.22 0.36 1.88e-9 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg22920501 chr2:26401640 FAM59B -0.69 -8.44 -0.46 2.06e-15 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13837895 chr19:50145301 SCAF1 0.54 7.49 0.42 1.05e-12 Systemic lupus erythematosus; CESC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg26850624 chr5:429559 AHRR -0.49 -6.62 -0.38 1.95e-10 Cystic fibrosis severity; CESC cis rs8020095 0.571 rs6573736 chr14:67374684 C/T cg19548862 chr14:67692701 FAM71D -0.48 -5.81 -0.34 1.81e-8 Depression (quantitative trait); CESC cis rs11645898 0.935 rs17603936 chr16:72169002 C/A cg14768367 chr16:72042858 DHODH -0.76 -6.48 -0.37 4.36e-10 Blood protein levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25266327 chr19:16435660 KLF2 -0.47 -6.15 -0.35 2.91e-9 Ulcerative colitis; CESC cis rs6963495 0.932 rs55700120 chr7:105148460 G/T cg02135003 chr7:105160482 PUS7 -0.47 -5.61 -0.33 5.12e-8 Bipolar disorder (body mass index interaction); CESC cis rs11741688 0.557 rs2004503 chr5:178337122 C/T cg20935368 chr5:178288625 ZNF354B 0.35 5.51 0.32 8.63e-8 Sleep duration; CESC cis rs2635047 0.967 rs12960444 chr18:44607314 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 8.29 0.45 5.74e-15 Educational attainment; CESC cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.52 0.46 1.25e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -7.54 -0.42 7.32e-13 Personality dimensions; CESC cis rs36051895 0.732 rs7046736 chr9:5015732 C/A cg02405213 chr9:5042618 JAK2 -0.47 -5.73 -0.33 2.72e-8 Pediatric autoimmune diseases; CESC cis rs66887589 0.870 rs10518336 chr4:120522934 G/A cg09307838 chr4:120376055 NA 0.55 7.21 0.4 5.87e-12 Diastolic blood pressure; CESC trans rs1493916 0.870 rs8083723 chr18:31384398 C/T cg27147174 chr7:100797783 AP1S1 -0.49 -6.72 -0.38 1.13e-10 Life satisfaction; CESC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg15445000 chr17:37608096 MED1 -0.41 -6.8 -0.39 6.8e-11 Glomerular filtration rate (creatinine); CESC cis rs933688 0.532 rs2973478 chr5:90553428 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.44 -5.11 -0.3 6.1e-7 Smoking behavior; CESC cis rs7296418 0.699 rs11608297 chr12:123826642 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.32 -5.11 -0.3 6.23e-7 Platelet count; CESC trans rs7577696 0.962 rs13022197 chr2:32343167 A/T cg05346536 chr7:128769728 NA 0.37 6.06 0.35 4.61e-9 Inflammatory biomarkers; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18632102 chr5:154238496 CNOT8 -0.53 -7.0 -0.4 2.15e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26807261 chr1:202857904 RABIF -0.47 -6.03 -0.35 5.43e-9 Ulcerative colitis; CESC cis rs17253792 0.822 rs76267907 chr14:56066969 C/A cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs10791097 0.547 rs10791101 chr11:130739133 C/T cg14779329 chr11:130786720 SNX19 0.34 5.12 0.3 5.95e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9443189 0.813 rs2647410 chr6:76433825 A/G cg01950844 chr6:76311363 SENP6 -0.6 -6.71 -0.38 1.15e-10 Prostate cancer; CESC cis rs12477438 0.520 rs11123764 chr2:99750677 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.91 15.68 0.69 1.18e-39 Chronic sinus infection; CESC cis rs1348850 0.526 rs4144278 chr2:178412378 C/T cg23306229 chr2:178417860 TTC30B 0.73 6.74 0.38 1.01e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg23758822 chr17:41437982 NA 1.01 15.33 0.69 2.06e-38 Menopause (age at onset); CESC cis rs10751667 1.000 rs4074232 chr11:977682 C/G cg01483505 chr11:975446 AP2A2 0.38 5.11 0.3 6.25e-7 Alzheimer's disease (late onset); CESC trans rs1218282 0.655 rs17771893 chr13:79466495 C/T cg17329304 chr1:6546083 PLEKHG5 0.8 6.28 0.36 1.42e-9 Response to statin therapy; CESC cis rs2070997 0.607 rs11244143 chr9:133670111 C/T cg11464064 chr9:133710261 ABL1 -0.59 -6.89 -0.39 4.11e-11 Response to amphetamines; CESC cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg10523679 chr1:76189770 ACADM 0.72 8.33 0.46 4.31e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs8141529 0.687 rs6005867 chr22:29165120 T/C cg15103426 chr22:29168792 CCDC117 0.73 10.06 0.53 2.17e-20 Lymphocyte counts; CESC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg01238044 chr22:24384105 GSTT1 -0.66 -8.42 -0.46 2.34e-15 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs763121 0.853 rs138704 chr22:39133410 A/G cg21395723 chr22:39101663 GTPBP1 0.5 6.9 0.39 3.89e-11 Menopause (age at onset); CESC cis rs9287719 0.753 rs2018512 chr2:10759279 T/G cg00105475 chr2:10696890 NA 0.35 5.07 0.3 7.65e-7 Prostate cancer; CESC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.57 0.8 2.94e-60 Prudent dietary pattern; CESC cis rs9929218 0.954 rs9929479 chr16:68821271 G/C cg02972257 chr16:68554789 NA 0.49 5.73 0.33 2.76e-8 Colorectal cancer; CESC cis rs694739 0.595 rs11606015 chr11:64136877 C/G cg02228329 chr11:64053129 BAD;GPR137 0.62 7.67 0.43 3.25e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs8018808 0.875 rs11159258 chr14:77880593 T/C cg20045696 chr14:77926864 AHSA1 0.47 6.5 0.37 3.87e-10 Myeloid white cell count; CESC cis rs7085104 0.514 rs284855 chr10:104574422 A/G cg23093090 chr10:104574429 C10orf26 0.34 5.41 0.32 1.42e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs4595586 0.545 rs67985200 chr12:39386891 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.51 0.32 8.37e-8 Morning vs. evening chronotype; CESC cis rs2228479 0.702 rs11076621 chr16:89837927 A/G cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02092590 chr10:3827595 KLF6 0.43 6.11 0.35 3.53e-9 Gut microbiota (bacterial taxa); CESC cis rs7188697 0.922 rs9926577 chr16:58613431 C/T cg21335942 chr16:58549945 SETD6 -0.45 -5.24 -0.31 3.34e-7 QT interval; CESC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg06481639 chr22:41940642 POLR3H -0.62 -6.57 -0.37 2.59e-10 Vitiligo; CESC cis rs2635047 0.638 rs2668761 chr18:44673049 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.51 0.32 8.62e-8 Educational attainment; CESC cis rs2933343 0.729 rs789231 chr3:128602847 A/G cg25356066 chr3:128598488 ACAD9 0.66 9.18 0.49 1.27e-17 IgG glycosylation; CESC cis rs796364 1.000 rs281785 chr2:200749566 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.87 8.38 0.46 3.1e-15 Schizophrenia; CESC cis rs17376456 0.825 rs12153021 chr5:93073913 A/G cg21475434 chr5:93447410 FAM172A 0.83 7.31 0.41 3.16e-12 Diabetic retinopathy; CESC cis rs6912958 0.516 rs242278 chr6:88047059 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.44 7.68 0.43 3.18e-13 Monocyte percentage of white cells; CESC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg26314531 chr2:26401878 FAM59B -0.61 -6.87 -0.39 4.62e-11 Gut microbiome composition (summer); CESC cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg11764359 chr7:65958608 NA 0.94 14.78 0.67 1.83e-36 Aortic root size; CESC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg17372223 chr3:52568218 NT5DC2 0.43 6.13 0.35 3.09e-9 Bipolar disorder; CESC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg02018176 chr4:1364513 KIAA1530 0.58 7.13 0.4 9.75e-12 Longevity; CESC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg08736216 chr1:53307985 ZYG11A -0.38 -6.48 -0.37 4.45e-10 Monocyte count; CESC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.7 6.59 0.38 2.36e-10 Lung function (FEV1/FVC); CESC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg09177884 chr7:1199841 ZFAND2A -0.5 -6.38 -0.36 7.97e-10 Longevity;Endometriosis; CESC cis rs9486719 0.843 rs2103539 chr6:96844342 T/A cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs2228479 0.850 rs62056065 chr16:89905115 C/G cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg10053473 chr17:62856997 LRRC37A3 -0.73 -7.76 -0.43 1.87e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg10295955 chr4:187884368 NA -1.1 -22.78 -0.81 2.32e-64 Lobe attachment (rater-scored or self-reported); CESC cis rs9796 0.621 rs9972349 chr15:41491656 A/G cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.61 -0.38 2.16e-10 Menopause (age at onset); CESC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03491503 chr16:69458309 CYB5B -0.5 -6.24 -0.36 1.73e-9 Ulcerative colitis; CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg07507251 chr3:52567010 NT5DC2 0.38 7.18 0.4 6.86e-12 Cognitive function; CESC cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 10.02 0.52 2.95e-20 Platelet count; CESC cis rs7914558 0.932 rs4307650 chr10:104959852 C/A cg04362960 chr10:104952993 NT5C2 0.47 6.4 0.37 6.83e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs8017423 1.000 rs769044 chr14:90671138 A/G cg14092571 chr14:90743983 NA -0.54 -7.93 -0.44 6.3e-14 Mortality in heart failure; CESC cis rs3820928 0.647 rs2115597 chr2:227791218 T/C cg11843606 chr2:227700838 RHBDD1 -0.58 -8.25 -0.45 7.39e-15 Pulmonary function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12894883 chr22:22288473 PPM1F 0.48 6.09 0.35 3.9e-9 Fibrinogen levels; CESC cis rs4268898 0.662 rs2303292 chr2:24432138 C/T cg20701182 chr2:24300061 SF3B14 0.68 7.16 0.4 7.75e-12 Asthma; CESC cis rs11098499 0.739 rs10031033 chr4:120151452 C/T cg09307838 chr4:120376055 NA 0.67 8.48 0.46 1.57e-15 Corneal astigmatism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05998816 chr21:47859926 PCNT 0.44 6.52 0.37 3.55e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10129255 0.500 rs4774189 chr14:107176517 G/T cg23076370 chr14:107095027 NA -0.6 -8.81 -0.48 1.73e-16 Kawasaki disease; CESC cis rs4965006 0.749 rs6598176 chr12:132425448 A/G cg00588090 chr12:132412438 PUS1 -0.47 -6.49 -0.37 4.13e-10 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg16240275 chr20:61666158 NCRNA00029 0.5 8.95 0.48 6.42e-17 Prostate cancer (SNP x SNP interaction); CESC trans rs10751667 1.000 rs10794349 chr11:945678 T/C cg00159523 chr10:114713187 TCF7L2 -0.4 -6.08 -0.35 4.26e-9 Alzheimer's disease (late onset); CESC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg12193833 chr17:30244370 NA 0.54 5.5 0.32 9.16e-8 Hip circumference adjusted for BMI; CESC cis rs910316 1.000 rs4322591 chr14:75600697 C/T cg11812906 chr14:75593930 NEK9 0.9 15.43 0.69 9.11e-39 Height; CESC cis rs7945705 0.967 rs7123861 chr11:8892323 G/A cg12365402 chr11:9010492 NRIP3 0.36 5.61 0.33 5.01e-8 Hemoglobin concentration; CESC cis rs6500602 0.627 rs3848372 chr16:4587875 C/A cg08645402 chr16:4508243 NA 0.45 6.63 0.38 1.82e-10 Schizophrenia; CESC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg24733560 chr20:60626293 TAF4 0.45 6.44 0.37 5.45e-10 Body mass index; CESC cis rs2050392 0.792 rs303434 chr10:30714440 G/A cg25182066 chr10:30743637 MAP3K8 -0.42 -5.76 -0.33 2.35e-8 Inflammatory bowel disease; CESC cis rs2415984 0.579 rs12147941 chr14:46972907 A/G cg14871534 chr14:47121158 RPL10L -0.34 -5.07 -0.3 7.39e-7 Number of children ever born; CESC cis rs9611565 0.729 rs132902 chr22:41797758 A/G cg06481639 chr22:41940642 POLR3H -0.57 -6.29 -0.36 1.27e-9 Vitiligo; CESC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg07648498 chr16:89883185 FANCA -0.49 -6.16 -0.35 2.63e-9 Vitiligo; CESC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg13777783 chr17:79615861 NA 0.34 5.74 0.33 2.59e-8 Eye color traits; CESC cis rs847577 0.748 rs13221897 chr7:97719699 G/A cg21770322 chr7:97807741 LMTK2 0.64 10.36 0.54 2.38e-21 Breast cancer; CESC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg10295955 chr4:187884368 NA -1.08 -22.84 -0.81 1.42e-64 Lobe attachment (rater-scored or self-reported); CESC cis rs8002861 0.727 rs9525852 chr13:44405197 G/C cg19180546 chr13:44453867 C13orf31;CCDC122 -0.39 -5.11 -0.3 6.17e-7 Leprosy; CESC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg24250549 chr1:154909240 PMVK 0.58 7.72 0.43 2.35e-13 Prostate cancer; CESC cis rs447 0.945 rs13310638 chr7:83761086 A/G cg22846510 chr7:83753280 SEMA3A -0.45 -5.57 -0.32 6.4e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7520050 0.807 rs4468203 chr1:46113272 T/C cg24296786 chr1:45957014 TESK2 -0.46 -5.96 -0.34 8e-9 Red blood cell count;Reticulocyte count; CESC trans rs2593957 0.503 rs9821382 chr3:108812154 A/G cg20104688 chr17:76183078 TK1;AFMID -0.54 -6.05 -0.35 5.04e-9 Colorectal cancer (diet interaction); CESC cis rs11249608 0.548 rs34054398 chr5:178458371 A/G cg01312482 chr5:178451176 ZNF879 -0.45 -6.04 -0.35 5.28e-9 Pubertal anthropometrics; CESC cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg18904891 chr8:8559673 CLDN23 0.73 8.12 0.45 1.74e-14 Obesity-related traits; CESC cis rs1046896 0.731 rs9906115 chr17:80791469 G/A cg19046167 chr17:80928561 B3GNTL1 0.43 5.04 0.3 8.55e-7 Glycated hemoglobin levels; CESC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg18758796 chr5:131593413 PDLIM4 0.43 5.89 0.34 1.2e-8 Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02912345 chr19:48308208 TPRX1 -0.57 -7.24 -0.41 4.94e-12 Gut microbiome composition (summer); CESC cis rs858239 0.571 rs6953020 chr7:23172132 T/C cg23682824 chr7:23144976 KLHL7 0.53 7.33 0.41 2.73e-12 Cerebrospinal fluid biomarker levels; CESC cis rs4242434 0.927 rs7843616 chr8:22466541 T/C cg03733263 chr8:22462867 KIAA1967 0.96 15.88 0.7 2.42e-40 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs12618769 0.597 rs72821924 chr2:99114924 C/T cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs4253772 0.515 rs9615969 chr22:46773592 C/G cg00784671 chr22:46762841 CELSR1 -0.65 -5.64 -0.33 4.45e-8 LDL cholesterol;Cholesterol, total; CESC trans rs9951602 0.512 rs9958497 chr18:76655296 G/C cg02800362 chr5:177631904 HNRNPAB 0.65 8.51 0.46 1.31e-15 Obesity-related traits; CESC cis rs1511802 0.666 rs3817184 chr4:187122304 C/T cg24794857 chr4:187113578 CYP4V2 0.44 5.84 0.34 1.56e-8 Blood protein levels; CESC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg21782813 chr7:2030301 MAD1L1 0.49 7.01 0.4 1.98e-11 Bipolar disorder and schizophrenia; CESC cis rs1790761 0.692 rs1148883 chr11:67304686 A/G cg24690094 chr11:67383802 NA 0.36 6.05 0.35 4.91e-9 Mean corpuscular volume; CESC cis rs3845702 0.935 rs6433822 chr2:180840422 G/C cg01881094 chr2:180872142 CWC22 -0.65 -6.85 -0.39 5.06e-11 Schizophrenia; CESC cis rs72627123 0.867 rs57731447 chr14:74487521 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.78 5.82 0.34 1.74e-8 Morning vs. evening chronotype; CESC cis rs7818382 1.000 rs7818382 chr8:96054000 C/T cg23172400 chr8:95962367 TP53INP1 -0.36 -7.18 -0.4 6.93e-12 Alzheimer's disease (late onset); CESC cis rs9309473 0.950 rs73947808 chr2:73721250 A/C cg20560298 chr2:73613845 ALMS1 -0.52 -6.4 -0.37 6.93e-10 Metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04204438 chr8:145634756 CPSF1 0.58 6.44 0.37 5.69e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23312248 chr12:123465515 ARL6IP4 0.57 6.23 0.36 1.84e-9 Gut microbiome composition (summer); CESC cis rs35995292 0.517 rs6948026 chr7:38920854 A/G cg19327137 chr7:38886074 VPS41 0.66 10.86 0.55 5.69e-23 Subjective well-being (multi-trait analysis); CESC cis rs9611565 0.571 rs2050032 chr22:42152429 C/T cg06481639 chr22:41940642 POLR3H 0.45 5.21 0.3 3.83e-7 Vitiligo; CESC cis rs116988415 0.584 rs74859785 chr14:65249684 C/T cg25083366 chr14:65239357 SPTB 0.66 5.14 0.3 5.23e-7 Daytime sleep phenotypes; CESC cis rs2228479 0.850 rs11641552 chr16:89838700 C/A cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs60733400 0.644 rs28774982 chr1:2621352 C/G cg20673091 chr1:2541236 MMEL1 -0.47 -7.52 -0.42 8.62e-13 Multiple sclerosis; CESC cis rs854765 0.583 rs4341796 chr17:17839024 C/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.52 7.13 0.4 9.44e-12 Total body bone mineral density; CESC cis rs13256369 0.802 rs11781257 chr8:8559663 A/T cg00074818 chr8:8560427 CLDN23 0.37 5.18 0.3 4.44e-7 Obesity-related traits; CESC cis rs12479064 0.724 rs10496336 chr2:99996165 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -7.3 -0.41 3.46e-12 Chronic sinus infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10024446 chr10:22048429 DNAJC1 0.56 7.43 0.42 1.49e-12 Fibrinogen levels; CESC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg11764359 chr7:65958608 NA -0.71 -9.5 -0.5 1.32e-18 Aortic root size; CESC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg22143856 chr6:28129313 ZNF389 0.42 5.26 0.31 2.91e-7 Parkinson's disease; CESC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg12311346 chr5:56204834 C5orf35 0.65 8.63 0.47 5.69e-16 Initial pursuit acceleration; CESC cis rs1348850 0.597 rs4893964 chr2:178447658 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 5.11 0.3 6.03e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs262150 0.851 rs2730249 chr7:158767628 A/G cg09640425 chr7:158790006 NA 0.35 5.36 0.31 1.84e-7 Facial morphology (factor 20); CESC cis rs2276314 0.857 rs6507158 chr18:33636066 A/C cg19628046 chr18:33552617 C18orf21 0.52 5.96 0.34 8.11e-9 Endometriosis;Drug-induced torsades de pointes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21403912 chr1:155239301 CLK2 -0.56 -6.5 -0.37 3.96e-10 Gut microbiome composition (summer); CESC cis rs6121246 0.909 rs6060793 chr20:30288830 T/G cg13852791 chr20:30311386 BCL2L1 0.79 8.3 0.45 5.47e-15 Mean corpuscular hemoglobin; CESC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg12963246 chr6:28129442 ZNF389 0.48 6.28 0.36 1.37e-9 Parkinson's disease; CESC cis rs8017423 0.935 rs7144335 chr14:90732280 A/G cg14092571 chr14:90743983 NA 0.55 8.14 0.45 1.55e-14 Mortality in heart failure; CESC cis rs4253772 0.530 rs9615990 chr22:46804154 G/A cg24881330 chr22:46731750 TRMU 0.67 5.35 0.31 1.92e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2243480 1.000 rs316313 chr7:65593548 G/A cg18252515 chr7:66147081 NA -1.41 -14.36 -0.66 5.44e-35 Diabetic kidney disease; CESC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg03709012 chr19:19516395 GATAD2A -0.98 -15.39 -0.69 1.25e-38 Tonsillectomy; CESC cis rs8028182 0.636 rs8036884 chr15:75862893 T/C cg20655648 chr15:75932815 IMP3 0.5 6.17 0.35 2.57e-9 Sudden cardiac arrest; CESC cis rs2832191 0.791 rs2832197 chr21:30497790 T/C cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.5e-20 Dental caries; CESC cis rs1797885 0.564 rs2596819 chr3:12600529 T/C cg26432171 chr3:12704882 RAF1 -0.51 -6.69 -0.38 1.29e-10 Immature fraction of reticulocytes; CESC cis rs6062302 0.522 rs4809312 chr20:62234240 C/T cg09650180 chr20:62225654 GMEB2 -0.82 -9.27 -0.49 6.91e-18 Glioblastoma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04562739 chr20:5107446 CDS2;PCNA -0.48 -6.58 -0.37 2.58e-10 Gut microbiota (bacterial taxa); CESC cis rs7772486 0.790 rs2247206 chr6:146216184 C/T cg05347473 chr6:146136440 FBXO30 0.53 6.92 0.39 3.46e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs10779751 1.000 rs4845854 chr1:11261929 T/C cg08854313 chr1:11322531 MTOR 0.88 12.81 0.62 1.4e-29 Body mass index; CESC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg24503407 chr1:205819492 PM20D1 -0.72 -9.95 -0.52 4.94e-20 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16632891 chr1:54872978 SSBP3 0.68 7.57 0.42 6.21e-13 Gut microbiome composition (summer); CESC cis rs2235642 0.826 rs8048410 chr16:1614097 A/G cg03771183 chr16:1608904 IFT140 0.43 6.24 0.36 1.7e-9 Coronary artery disease; CESC cis rs9894429 0.546 rs9906979 chr17:79608765 A/G cg18240062 chr17:79603768 NPLOC4 0.67 8.91 0.48 8.4e-17 Eye color traits; CESC trans rs7307889 0.793 rs7489044 chr12:6009595 A/G cg18407955 chr7:158110685 PTPRN2 -0.71 -6.58 -0.37 2.48e-10 Obesity-related traits; CESC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg12667521 chr19:29218732 NA 0.49 6.66 0.38 1.6e-10 Methadone dose in opioid dependence; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00747290 chr2:42721154 KCNG3 -0.48 -6.22 -0.36 1.93e-9 Fibrinogen levels; CESC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.64 0.33 4.35e-8 Bipolar disorder; CESC cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg23018236 chr17:30244563 NA -0.53 -5.21 -0.3 3.76e-7 Hip circumference adjusted for BMI; CESC cis rs17433710 0.516 rs6689396 chr1:162676698 C/T cg21140079 chr1:162667252 DDR2 -0.39 -5.09 -0.3 6.85e-7 Dupuytren's disease; CESC cis rs11214589 0.807 rs2155463 chr11:113242301 T/C cg14159747 chr11:113255604 NA 0.3 5.48 0.32 9.93e-8 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09297334 chr8:71520303 TRAM1 -0.67 -7.74 -0.43 2.15e-13 Gut microbiome composition (summer); CESC cis rs9640161 0.742 rs2159235 chr7:150017228 T/C cg21361702 chr7:150065534 REPIN1 0.55 6.44 0.37 5.71e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.37 -0.57 1.18e-24 Type 2 diabetes; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg14173624 chr17:72199366 RPL38 -0.44 -5.99 -0.35 6.63e-9 Height; CESC trans rs526821 0.595 rs551665 chr11:55343268 G/A cg03929089 chr4:120376271 NA -0.5 -6.07 -0.35 4.34e-9 Pediatric bone mineral density (spine); CESC cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg08917208 chr2:24149416 ATAD2B 0.61 5.85 0.34 1.43e-8 Lymphocyte counts; CESC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg21144161 chr5:423903 AHRR 0.37 6.09 0.35 3.9e-9 Cystic fibrosis severity; CESC cis rs12461016 1 rs12461016 chr19:17161687 G/A cg16202187 chr19:17186497 HAUS8;MYO9B 0.51 6.63 0.38 1.84e-10 Diastolic blood pressure; CESC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.07 10.75 0.55 1.35e-22 Platelet count; CESC cis rs2463822 0.583 rs72919472 chr11:62040655 C/T cg06239285 chr11:62104954 ASRGL1 -1.06 -8.68 -0.47 4.09e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9948 0.655 rs6758151 chr2:97388884 A/G cg01990225 chr2:97406019 LMAN2L -0.87 -7.31 -0.41 3.22e-12 Erectile dysfunction and prostate cancer treatment; CESC cis rs4253772 0.530 rs6008662 chr22:46713917 G/A cg07012999 chr22:46692446 CN5H6.4;GTSE1 0.54 5.59 0.33 5.51e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7831492 0.564 rs7831530 chr8:41614567 G/A cg17182837 chr8:41585554 ANK1 -0.41 -6.34 -0.36 9.67e-10 Colorectal cancer; CESC cis rs1451375 0.607 rs7807335 chr7:50631862 A/C cg14593290 chr7:50529359 DDC -0.45 -5.43 -0.32 1.29e-7 Malaria; CESC cis rs637571 0.522 rs1786175 chr11:65754808 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.51 0.37 3.81e-10 Eosinophil percentage of white cells; CESC cis rs6500602 0.674 rs7191664 chr16:4541924 T/C cg08645402 chr16:4508243 NA 0.43 6.32 0.36 1.09e-9 Schizophrenia; CESC cis rs2380220 0.510 rs9387562 chr6:96057006 G/T cg04719120 chr6:96025338 MANEA 0.63 6.74 0.38 1.01e-10 Behavioural disinhibition (generation interaction); CESC cis rs3096299 0.629 rs12929744 chr16:89493580 G/C cg02187348 chr16:89574699 SPG7 0.5 6.06 0.35 4.74e-9 Multiple myeloma (IgH translocation); CESC cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg10845886 chr2:3471009 TTC15 0.68 9.23 0.49 9.14e-18 Neurofibrillary tangles; CESC cis rs6964587 1.000 rs3753109 chr7:91630001 G/C cg17063962 chr7:91808500 NA 0.57 7.74 0.43 2.04e-13 Breast cancer; CESC cis rs672059 1.000 rs544352 chr1:183157546 G/A ch.1.3577855R chr1:183094577 LAMC1 0.54 6.97 0.39 2.51e-11 Hypertriglyceridemia; CESC cis rs9911578 1.000 rs11079365 chr17:56945430 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.16 0.3 4.87e-7 Intelligence (multi-trait analysis); CESC cis rs1448094 0.872 rs1026085 chr12:86355735 A/G cg02569458 chr12:86230093 RASSF9 0.35 5.2 0.3 4.06e-7 Major depressive disorder; CESC cis rs4808199 0.948 rs2074300 chr19:19380996 G/T cg03709012 chr19:19516395 GATAD2A 1.08 11.68 0.58 1.02e-25 Nonalcoholic fatty liver disease; CESC cis rs6952809 0.532 rs6461361 chr7:2432167 A/G cg23289794 chr7:2394357 EIF3B -0.87 -7.7 -0.43 2.69e-13 Multiple sclerosis; CESC trans rs17508449 0.819 rs77892281 chr1:114163617 A/T cg23028848 chr11:57092561 TNKS1BP1 -0.74 -6.0 -0.35 6.52e-9 Leprosy; CESC cis rs116095464 0.558 rs62346506 chr5:201594 T/C cg22857025 chr5:266934 NA -1.27 -14.49 -0.66 2e-35 Breast cancer; CESC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 11.76 0.59 5.69e-26 Platelet count; CESC cis rs6582630 0.539 rs8189604 chr12:38308546 G/T cg26384229 chr12:38710491 ALG10B -0.44 -5.76 -0.33 2.35e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg09658497 chr7:2847517 GNA12 -0.44 -6.14 -0.35 3.06e-9 Height; CESC cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.36 0.54 2.38e-21 Monocyte percentage of white cells; CESC cis rs4964805 0.586 rs934846 chr12:104185297 C/T cg02344784 chr12:104178138 NT5DC3 0.5 7.26 0.41 4.23e-12 Attention deficit hyperactivity disorder; CESC trans rs968059 0.669 rs4670455 chr2:35448902 C/G cg14806518 chr2:503692 NA 0.39 6.0 0.35 6.59e-9 Body mass index; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16754766 chr12:42877927 PRICKLE1 0.52 6.82 0.39 6.09e-11 Systemic lupus erythematosus; CESC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg06634786 chr22:41940651 POLR3H 0.68 6.72 0.38 1.13e-10 Vitiligo; CESC cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg23711669 chr6:146136114 FBXO30 1.03 15.86 0.7 2.71e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs3749237 0.595 rs7621003 chr3:49411404 T/C cg06212747 chr3:49208901 KLHDC8B 0.53 7.2 0.4 6.08e-12 Resting heart rate; CESC trans rs11039798 0.588 rs1847640 chr11:49004025 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.79 0.38 7.18e-11 Axial length; CESC cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs593982 0.920 rs1151501 chr11:65484883 A/G cg08755490 chr11:65554678 OVOL1 1.18 10.7 0.55 1.97e-22 Atopic dermatitis; CESC cis rs722599 0.748 rs929579 chr14:75330697 C/T cg08847533 chr14:75593920 NEK9 -0.45 -5.64 -0.33 4.44e-8 IgG glycosylation; CESC cis rs10876993 0.890 rs774887 chr12:58034835 A/G cg18357645 chr12:58087776 OS9 0.59 9.13 0.49 1.77e-17 Celiac disease or Rheumatoid arthritis; CESC cis rs854765 0.547 rs2955356 chr17:17964717 G/A cg16928487 chr17:17741425 SREBF1 0.56 9.38 0.5 3e-18 Total body bone mineral density; CESC cis rs7116495 1.000 rs2511116 chr11:71802160 G/A cg26138937 chr11:71823887 C11orf51 -0.86 -7.03 -0.4 1.75e-11 Severe influenza A (H1N1) infection; CESC cis rs453301 0.686 rs17702602 chr8:8908596 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -6.3 -0.36 1.26e-9 Joint mobility (Beighton score); CESC cis rs10779751 0.726 rs1205593 chr1:11252716 T/C cg08854313 chr1:11322531 MTOR 0.75 8.89 0.48 9.58e-17 Body mass index; CESC cis rs9560113 0.597 rs1163644 chr13:112241223 C/T cg10483660 chr13:112241077 NA -0.46 -7.9 -0.44 7.51e-14 Menarche (age at onset); CESC cis rs868036 1.000 rs4776377 chr15:68103387 T/C cg08079166 chr15:68083412 MAP2K5 0.43 6.92 0.39 3.35e-11 Restless legs syndrome; CESC cis rs5769765 1.000 rs4597652 chr22:50270570 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs561341 1.000 rs550923 chr17:30327013 G/C cg23018236 chr17:30244563 NA -0.52 -5.11 -0.3 6.12e-7 Hip circumference adjusted for BMI; CESC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg09365446 chr1:150670422 GOLPH3L 0.4 5.39 0.31 1.59e-7 Melanoma; CESC cis rs11190604 0.945 rs11190573 chr10:102233172 T/C cg07080220 chr10:102295463 HIF1AN 0.55 5.56 0.32 6.43e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg12648201 chr2:27665141 KRTCAP3 -0.31 -5.65 -0.33 4.22e-8 Total body bone mineral density; CESC cis rs35110281 0.591 rs162366 chr21:44935383 C/T cg21573476 chr21:45109991 RRP1B 0.38 5.38 0.31 1.68e-7 Mean corpuscular volume; CESC cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg11764359 chr7:65958608 NA -0.62 -7.83 -0.43 1.18e-13 Aortic root size; CESC cis rs6842047 1.000 rs10471184 chr4:187122904 C/T cg23442198 chr4:187126114 CYP4V2 -0.68 -5.41 -0.32 1.38e-7 Blood protein levels; CESC cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg25427524 chr10:38739819 LOC399744 -0.66 -9.52 -0.5 1.15e-18 Extrinsic epigenetic age acceleration; CESC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg13206674 chr6:150067644 NUP43 0.42 5.67 0.33 3.66e-8 Lung cancer; CESC cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg11752832 chr7:134001865 SLC35B4 0.51 6.53 0.37 3.4e-10 Mean platelet volume; CESC cis rs2262909 0.962 rs422344 chr19:22230956 C/G cg11619707 chr19:22235551 ZNF257 0.32 5.29 0.31 2.53e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs7772486 0.743 rs9390344 chr6:146012755 C/G cg05347473 chr6:146136440 FBXO30 -0.47 -6.09 -0.35 3.88e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs7590720 0.704 rs7603645 chr2:216876949 C/G cg12620499 chr2:216877984 MREG 0.9 14.32 0.66 7.73e-35 Alcohol dependence; CESC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg18240062 chr17:79603768 NPLOC4 0.54 7.05 0.4 1.56e-11 Eye color traits; CESC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg00166722 chr3:10149974 C3orf24 0.48 5.98 0.34 7.15e-9 Alzheimer's disease; CESC cis rs1707322 1.000 rs1768807 chr1:46510570 A/G cg03146154 chr1:46216737 IPP -0.72 -9.73 -0.51 2.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2249625 1.000 rs55970804 chr6:72923351 G/A cg18830697 chr6:72922368 RIMS1 0.37 5.17 0.3 4.58e-7 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs644799 0.544 rs1527450 chr11:95467777 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.66 9.41 0.5 2.48e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9488822 0.676 rs3798227 chr6:116324898 A/G cg26893134 chr6:116381904 FRK 0.25 6.04 0.35 5.06e-9 Cholesterol, total;LDL cholesterol; CESC cis rs634534 0.622 rs501353 chr11:65739549 T/G cg04055107 chr11:65626734 MUS81;CFL1 0.44 5.59 0.32 5.77e-8 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg11494091 chr17:61959527 GH2 0.72 12.39 0.61 4.12e-28 Prudent dietary pattern; CESC cis rs9902453 0.904 rs9894893 chr17:28270350 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 9.16 0.49 1.49e-17 Coffee consumption (cups per day); CESC cis rs1580019 0.813 rs2044839 chr7:32500805 A/C cg07520158 chr7:32535189 LSM5;AVL9 0.43 5.13 0.3 5.64e-7 Cognitive ability; CESC cis rs9487051 0.700 rs7773815 chr6:109602343 A/C cg01475377 chr6:109611718 NA -0.44 -7.01 -0.4 2.01e-11 Reticulocyte fraction of red cells; CESC cis rs6598955 0.724 rs12096059 chr1:26596709 G/A cg04990556 chr1:26633338 UBXN11 -0.78 -11.2 -0.57 4.2e-24 Obesity-related traits; CESC cis rs6424115 0.793 rs2502998 chr1:24198327 T/A cg15997130 chr1:24165203 NA 0.38 5.11 0.3 6.3e-7 Immature fraction of reticulocytes; CESC trans rs11098499 0.618 rs28491261 chr4:120294900 C/A cg25214090 chr10:38739885 LOC399744 0.69 9.31 0.5 4.95e-18 Corneal astigmatism; CESC cis rs2299587 0.554 rs9325823 chr8:17735871 A/G cg08627089 chr8:17753878 FGL1 0.42 5.97 0.34 7.74e-9 Economic and political preferences; CESC cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4803468 1.000 rs4803469 chr19:41922775 A/C cg14132834 chr19:41945861 ATP5SL -0.68 -8.41 -0.46 2.55e-15 Height; CESC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg12648201 chr2:27665141 KRTCAP3 -0.32 -5.67 -0.33 3.81e-8 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21765577 chr8:145150022 CYC1 0.57 6.74 0.38 9.6e-11 Gut microbiome composition (summer); CESC cis rs7264396 0.690 rs2425164 chr20:34434916 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.39 0.41 1.97e-12 Total cholesterol levels; CESC cis rs11630290 0.566 rs4777395 chr15:64161693 T/G cg12036633 chr15:63758958 NA 0.44 5.25 0.31 3.05e-7 Iris characteristics; CESC cis rs459571 0.792 rs55923934 chr9:136888233 C/G cg13789015 chr9:136890014 NCRNA00094 0.56 8.06 0.44 2.65e-14 Platelet distribution width; CESC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg18402987 chr7:1209562 NA 0.75 8.45 0.46 1.94e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4423214 0.569 rs4944044 chr11:71120213 G/A cg05163923 chr11:71159392 DHCR7 0.56 7.5 0.42 9.41e-13 Vitamin D levels; CESC cis rs34638657 0.872 rs6420435 chr16:82184201 A/C cg09439754 chr16:82129088 HSD17B2 -0.34 -5.14 -0.3 5.27e-7 Lung adenocarcinoma; CESC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg08888203 chr3:10149979 C3orf24 0.49 6.33 0.36 1.05e-9 Alzheimer's disease; CESC cis rs7551222 0.752 rs16853865 chr1:204465659 A/G cg20240347 chr1:204465584 NA -0.26 -5.32 -0.31 2.22e-7 Schizophrenia; CESC cis rs9913156 0.793 rs55677157 chr17:4576620 C/T cg00122941 chr17:4613640 ARRB2 0.86 10.05 0.53 2.34e-20 Lymphocyte counts; CESC cis rs2832191 0.791 rs2832186 chr21:30484151 A/C cg08807101 chr21:30365312 RNF160 -0.73 -10.3 -0.53 3.86e-21 Dental caries; CESC cis rs7605827 0.866 rs13016989 chr2:15514338 T/A cg19274914 chr2:15703543 NA 0.32 5.54 0.32 7.25e-8 Educational attainment (years of education); CESC cis rs4925386 0.802 rs6142735 chr20:60918087 G/C cg22633769 chr20:60982531 CABLES2 0.56 5.59 0.32 5.57e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs3008870 0.917 rs12044492 chr1:67461667 T/C cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.19 -0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg02725872 chr8:58115012 NA -0.4 -5.26 -0.31 2.91e-7 Developmental language disorder (linguistic errors); CESC cis rs2070488 0.775 rs7649984 chr3:38570221 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.76 -11.59 -0.58 2.17e-25 Electrocardiographic conduction measures; CESC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg09658497 chr7:2847517 GNA12 -0.36 -5.11 -0.3 6.19e-7 Height; CESC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.7 -0.33 3.25e-8 Total body bone mineral density; CESC cis rs1371867 0.846 rs2083499 chr8:101230534 T/A cg11906718 chr8:101322791 RNF19A -0.5 -6.19 -0.36 2.22e-9 Atrioventricular conduction; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04184623 chr2:217277352 SMARCAL1 0.43 6.11 0.35 3.48e-9 Gut microbiota (bacterial taxa); CESC cis rs208520 0.661 rs207099 chr6:66796373 A/C cg07460842 chr6:66804631 NA -1.01 -13.47 -0.64 7.24e-32 Exhaled nitric oxide output; CESC cis rs7537660 0.704 rs4925741 chr1:248007696 A/G cg12080717 chr1:248004886 OR11L1 -0.42 -5.07 -0.3 7.31e-7 Platelet distribution width; CESC cis rs6088580 0.608 rs2105109 chr20:32971932 A/G cg06115741 chr20:33292138 TP53INP2 -0.46 -5.96 -0.34 7.8e-9 Glomerular filtration rate (creatinine); CESC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg06074448 chr4:187884817 NA -0.48 -7.37 -0.41 2.15e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg27266027 chr21:40555129 PSMG1 0.44 5.23 0.31 3.42e-7 Cognitive function; CESC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg11859384 chr17:80120422 CCDC57 -0.4 -5.46 -0.32 1.11e-7 Life satisfaction; CESC trans rs62103177 0.810 rs62103188 chr18:77627661 G/A cg05926928 chr17:57297772 GDPD1 1.18 10.14 0.53 1.27e-20 Opioid sensitivity; CESC cis rs10870270 0.957 rs3753008 chr10:133785129 A/C cg17892150 chr10:133769511 PPP2R2D -0.82 -11.95 -0.59 1.34e-26 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs10089 1.000 rs6887847 chr5:127473807 A/G cg19767477 chr5:127420684 SLC12A2 -0.4 -5.41 -0.32 1.42e-7 Ileal carcinoids; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10688328 chr15:31684499 NA 0.51 6.7 0.38 1.24e-10 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.800 rs10008654 chr4:98820498 C/A cg17366294 chr4:99064904 C4orf37 0.55 7.51 0.42 9.06e-13 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11942622 chr15:79298659 RASGRF1 0.45 6.39 0.37 7.62e-10 Fibrinogen levels; CESC trans rs17508449 0.819 rs4589108 chr1:114259625 T/A cg23028848 chr11:57092561 TNKS1BP1 -0.76 -6.06 -0.35 4.57e-9 Leprosy; CESC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg06873352 chr17:61820015 STRADA 0.73 12.83 0.62 1.24e-29 Prudent dietary pattern; CESC cis rs11645898 0.872 rs72787093 chr16:72190766 C/T cg14768367 chr16:72042858 DHODH -0.75 -6.29 -0.36 1.32e-9 Blood protein levels; CESC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC cis rs79349575 0.783 rs17635252 chr17:47006950 T/C cg16584676 chr17:46985605 UBE2Z 0.53 6.54 0.37 3.16e-10 Type 2 diabetes; CESC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg19774624 chr17:42201019 HDAC5 -0.88 -13.31 -0.63 2.75e-31 Total body bone mineral density; CESC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg11890956 chr21:40555474 PSMG1 -0.92 -14.67 -0.67 4.52e-36 Cognitive function; CESC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg19717773 chr7:2847554 GNA12 -0.57 -8.4 -0.46 2.78e-15 Height; CESC trans rs208520 0.954 rs12190073 chr6:66983740 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.33 0.5 4.5e-18 Exhaled nitric oxide output; CESC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC trans rs748404 0.578 rs512628 chr15:43618734 A/G cg24053811 chr14:70265306 SLC10A1 0.42 6.03 0.35 5.55e-9 Lung cancer; CESC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg25072359 chr17:41440525 NA 0.45 6.76 0.38 8.79e-11 Menopause (age at onset); CESC cis rs10411936 0.712 rs10414751 chr19:16591695 G/A cg10248733 chr19:16607483 C19orf44;CALR3 0.57 6.81 0.39 6.51e-11 White blood cell count;Multiple sclerosis; CESC cis rs9457247 0.967 rs2769346 chr6:167370999 A/G cg25258033 chr6:167368657 RNASET2 -0.42 -6.24 -0.36 1.73e-9 Crohn's disease; CESC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg27572855 chr1:25598939 RHD 0.44 7.32 0.41 3.02e-12 Erythrocyte sedimentation rate; CESC cis rs11048434 0.736 rs12812913 chr12:9110836 C/G cg23795048 chr12:9217529 LOC144571 0.35 5.4 0.31 1.52e-7 Sjögren's syndrome; CESC cis rs73206853 0.609 rs7966169 chr12:111045898 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 5.87 0.34 1.33e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2204008 0.774 rs9669565 chr12:38294428 C/A cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Bladder cancer; CESC cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7116495 0.737 rs6592456 chr11:71737663 G/A cg10381502 chr11:71823885 C11orf51 -1.12 -6.73 -0.38 1.03e-10 Severe influenza A (H1N1) infection; CESC cis rs11249608 0.548 rs13161528 chr5:178452958 C/G cg21905437 chr5:178450457 ZNF879 0.6 8.72 0.47 3.05e-16 Pubertal anthropometrics; CESC cis rs1348850 0.872 rs4893825 chr2:178298687 A/G cg23306229 chr2:178417860 TTC30B 0.58 6.88 0.39 4.28e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs858239 0.539 rs10254544 chr7:23220235 T/C cg23682824 chr7:23144976 KLHL7 0.45 5.83 0.34 1.58e-8 Cerebrospinal fluid biomarker levels; CESC cis rs904092 0.720 rs1230019 chr4:100172691 A/G cg12011299 chr4:100065546 ADH4 0.54 6.13 0.35 3.23e-9 Alcohol dependence; CESC cis rs3774749 0.565 rs2518796 chr3:50207075 A/G cg24308560 chr3:49941425 MST1R -0.43 -5.75 -0.33 2.43e-8 Intelligence (multi-trait analysis); CESC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg01097406 chr16:89675127 NA 0.37 5.27 0.31 2.87e-7 Vitiligo; CESC cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.22 0.36 1.96e-9 Hip circumference adjusted for BMI; CESC cis rs6032067 0.777 rs2868234 chr20:43794026 C/T cg11264863 chr20:43835661 SEMG1 0.5 5.35 0.31 1.86e-7 Blood protein levels; CESC cis rs11190604 1.000 rs3750633 chr10:102308214 C/T cg07080220 chr10:102295463 HIF1AN 0.62 5.65 0.33 4.17e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs1707322 0.686 rs2230658 chr1:46078854 A/G cg06784218 chr1:46089804 CCDC17 -0.43 -7.41 -0.41 1.7e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2242116 0.761 rs6780601 chr3:46965856 A/G cg02527881 chr3:46936655 PTH1R -0.5 -7.06 -0.4 1.46e-11 Birth weight; CESC cis rs3126085 0.935 rs6587651 chr1:152193121 G/T cg03465714 chr1:152285911 FLG -0.42 -5.14 -0.3 5.24e-7 Atopic dermatitis; CESC cis rs11190604 1.000 rs7080356 chr10:102266735 A/C cg07080220 chr10:102295463 HIF1AN 0.61 5.78 0.33 2.06e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs28830936 0.510 rs2412640 chr15:42124082 C/T cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 0.35 5.43 0.32 1.29e-7 Diastolic blood pressure; CESC trans rs8073060 0.586 rs3859284 chr17:34012792 C/T cg19694781 chr19:47549865 TMEM160 -0.74 -6.91 -0.39 3.64e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs9911578 0.933 rs2531725 chr17:56517962 G/A cg05425664 chr17:57184151 TRIM37 -0.49 -6.82 -0.39 6.08e-11 Intelligence (multi-trait analysis); CESC cis rs919433 1.000 rs2195510 chr2:198161195 A/G cg03934865 chr2:198174659 NA -0.47 -7.15 -0.4 8.41e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs12136530 0.774 rs12137192 chr1:19763458 C/G cg01832549 chr1:19774989 CAPZB -0.46 -6.5 -0.37 3.9e-10 Lead levels in blood; CESC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg07308232 chr7:1071921 C7orf50 0.45 6.25 0.36 1.65e-9 Longevity;Endometriosis; CESC cis rs1707322 1.000 rs4524994 chr1:46370263 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg16278512 chr7:12443529 VWDE -0.55 -5.87 -0.34 1.27e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11241278 chr17:74023465 EVPL -0.48 -6.83 -0.39 5.96e-11 Gut microbiome composition (summer); CESC cis rs5758659 0.714 rs6002626 chr22:42517989 C/G cg05082376 chr22:42548792 NA 0.35 5.11 0.3 6.08e-7 Cognitive function; CESC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg18301423 chr5:131593218 PDLIM4 0.38 5.54 0.32 7.36e-8 Breast cancer; CESC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg19468946 chr17:37922297 IKZF3 0.4 5.13 0.3 5.56e-7 Glomerular filtration rate (creatinine); CESC cis rs6503863 1 rs6503863 chr17:56517034 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.49 6.64 0.38 1.74e-10 Intelligence (multi-trait analysis); CESC cis rs7532866 0.848 rs12401866 chr1:26726967 C/G cg17456097 chr1:26900765 RPS6KA1 -0.49 -6.34 -0.36 9.91e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24748448 chr17:3493352 TRPV1 -0.54 -6.43 -0.37 5.8e-10 Gut microbiome composition (summer); CESC cis rs10504073 0.584 rs56078938 chr8:49940342 A/C cg00325661 chr8:49890786 NA 0.59 8.79 0.47 1.99e-16 Blood metabolite ratios; CESC cis rs3767633 1.000 rs3767633 chr1:161826615 T/A cg09175582 chr1:161736000 ATF6 0.86 6.88 0.39 4.35e-11 IgG glycosylation; CESC cis rs2273669 0.585 rs6900472 chr6:109372120 G/A cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs7247513 1.000 rs2042947 chr19:12693103 A/G cg01871581 chr19:12707946 ZNF490 -0.87 -14.92 -0.68 5.76e-37 Bipolar disorder; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg21790971 chr4:54244117 FIP1L1 0.47 6.04 0.35 5.17e-9 Tetralogy of Fallot; CESC cis rs9488822 0.676 rs6918059 chr6:116349041 C/T cg18764771 chr6:116381957 FRK 0.23 5.7 0.33 3.15e-8 Cholesterol, total;LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17785250 chr5:140554081 PCDHB7 -0.54 -6.31 -0.36 1.18e-9 Gut microbiome composition (summer); CESC cis rs7827545 0.545 rs6988000 chr8:135559534 C/T cg17885191 chr8:135476712 NA 0.51 5.61 0.33 4.98e-8 Hypertension (SNP x SNP interaction); CESC cis rs1185460 0.967 rs1786690 chr11:118942067 A/G cg23280166 chr11:118938394 VPS11 0.5 6.57 0.37 2.6e-10 Coronary artery disease; CESC cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg15164180 chr2:241846931 NA -0.34 -5.16 -0.3 4.77e-7 Urinary metabolites; CESC cis rs3741151 0.892 rs77127734 chr11:73018413 T/A cg17517138 chr11:73019481 ARHGEF17 0.75 6.24 0.36 1.76e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7312933 0.584 rs7974654 chr12:42630466 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 6.07 0.35 4.44e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs12477438 0.765 rs72957180 chr2:99694452 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg05368731 chr17:41323189 NBR1 -0.79 -11.32 -0.57 1.76e-24 Menopause (age at onset); CESC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs8114671 0.836 rs3746432 chr20:33592763 C/T cg07148914 chr20:33460835 GGT7 -0.41 -5.37 -0.31 1.75e-7 Height; CESC cis rs12681288 0.676 rs34435811 chr8:990630 T/A cg15309053 chr8:964076 NA 0.37 6.32 0.36 1.08e-9 Schizophrenia; CESC cis rs796364 0.951 rs13029537 chr2:200998950 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.68 -6.65 -0.38 1.7e-10 Schizophrenia; CESC cis rs7508 0.640 rs373983 chr8:17911905 C/T cg18067069 chr8:17937731 ASAH1 -0.38 -5.18 -0.3 4.3e-7 Atrial fibrillation; CESC cis rs2486288 0.656 rs12910009 chr15:45572408 A/G cg09092052 chr15:45571596 NA 0.44 5.23 0.31 3.44e-7 Glomerular filtration rate; CESC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg27211696 chr2:191398769 TMEM194B 0.5 7.49 0.42 1.06e-12 Pulse pressure; CESC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.38 0.31 1.63e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6714710 0.580 rs1838797 chr2:98454572 G/C cg26665480 chr2:98280029 ACTR1B 0.57 8.02 0.44 3.49e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.94 0.39 3e-11 Electroencephalogram traits; CESC cis rs6088580 0.634 rs1205336 chr20:32926336 G/A cg24642439 chr20:33292090 TP53INP2 -0.51 -6.63 -0.38 1.85e-10 Glomerular filtration rate (creatinine); CESC cis rs2933343 0.729 rs1680785 chr3:128644816 C/T cg25356066 chr3:128598488 ACAD9 0.6 8.44 0.46 2.09e-15 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09087777 chr3:150321365 SELT 0.55 6.31 0.36 1.19e-9 Gut microbiome composition (summer); CESC cis rs9303401 0.614 rs35245220 chr17:56510305 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.91 10.51 0.54 8.15e-22 Cognitive test performance; CESC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg14983838 chr19:29218262 NA 0.5 6.16 0.35 2.67e-9 Methadone dose in opioid dependence; CESC trans rs7173947 0.646 rs11634297 chr15:95267564 A/T cg04728121 chr14:89883534 FOXN3 -0.47 -6.37 -0.36 8.34e-10 Hematological and biochemical traits; CESC cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg08822215 chr16:89438651 ANKRD11 -0.4 -6.08 -0.35 4.26e-9 Multiple myeloma (IgH translocation); CESC cis rs11792861 1.000 rs11792861 chr9:111809295 A/C cg05043794 chr9:111880884 C9orf5 -0.39 -6.38 -0.37 7.65e-10 Menarche (age at onset); CESC cis rs1385374 0.858 rs10847698 chr12:129300222 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 0.6 5.22 0.31 3.61e-7 Systemic lupus erythematosus; CESC cis rs9611565 0.592 rs5751139 chr22:42099981 G/C cg06481639 chr22:41940642 POLR3H 0.59 5.95 0.34 8.35e-9 Vitiligo; CESC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.39 -0.37 7.41e-10 Depression; CESC cis rs8067545 0.611 rs12949481 chr17:20190974 C/A cg13482628 chr17:19912719 NA -0.42 -5.62 -0.33 4.73e-8 Schizophrenia; CESC cis rs9527 0.590 rs7092029 chr10:104823909 A/T cg04362960 chr10:104952993 NT5C2 0.45 5.76 0.33 2.34e-8 Arsenic metabolism; CESC cis rs11958404 0.789 rs72800604 chr5:157502940 C/T cg05962755 chr5:157440814 NA 0.55 6.33 0.36 1.04e-9 IgG glycosylation; CESC cis rs5498 0.869 rs892188 chr19:10409793 A/G cg22910295 chr19:10403862 ICAM5 -0.42 -5.9 -0.34 1.11e-8 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg07701084 chr6:150067640 NUP43 0.43 6.0 0.35 6.62e-9 Lung cancer; CESC cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg12386194 chr3:101231763 SENP7 0.44 5.42 0.32 1.31e-7 Colorectal cancer; CESC cis rs2933343 0.601 rs1680758 chr3:128594897 T/C cg25356066 chr3:128598488 ACAD9 0.63 8.81 0.48 1.64e-16 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14843989 chr17:10600751 C17orf48;SCO1 0.52 6.07 0.35 4.39e-9 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg00409905 chr10:38381863 ZNF37A -0.47 -6.3 -0.36 1.24e-9 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09313436 chr12:49960191 MCRS1 -0.53 -6.15 -0.35 2.91e-9 Gut microbiome composition (summer); CESC cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg22875332 chr1:76189707 ACADM 0.63 7.33 0.41 2.78e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4604732 0.578 rs112449432 chr1:247624180 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 7.39 0.41 1.98e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6540556 0.954 rs6540555 chr1:209936571 A/G cg23920097 chr1:209922102 NA -0.36 -5.28 -0.31 2.7e-7 Red blood cell count; CESC cis rs6748734 1.000 rs3936203 chr2:241834654 C/T cg07537917 chr2:241836409 C2orf54 0.25 5.32 0.31 2.18e-7 Urinary metabolites; CESC trans rs17536732 0.786 rs10517756 chr4:162847919 C/T cg12177677 chr2:158300475 CYTIP -0.64 -6.25 -0.36 1.66e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg11366901 chr6:160182831 ACAT2 0.8 9.78 0.52 1.69e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs7605827 0.897 rs13014906 chr2:15614404 T/C cg19274914 chr2:15703543 NA 0.35 6.22 0.36 1.93e-9 Educational attainment (years of education); CESC cis rs11608355 0.521 rs6606707 chr12:109830241 T/G cg19025524 chr12:109796872 NA -0.54 -7.7 -0.43 2.8e-13 Neuroticism; CESC cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg03060546 chr3:49711283 APEH 0.44 5.44 0.32 1.18e-7 Parkinson's disease; CESC cis rs684232 0.602 rs448465 chr17:559888 A/T cg15660573 chr17:549704 VPS53 -0.75 -10.74 -0.55 1.41e-22 Prostate cancer; CESC cis rs6748734 0.625 rs9288743 chr2:241821569 C/G cg04034577 chr2:241836375 C2orf54 -0.29 -5.32 -0.31 2.23e-7 Urinary metabolites; CESC cis rs7089973 0.604 rs17663387 chr10:116588060 C/G cg25233709 chr10:116636983 FAM160B1 0.35 5.71 0.33 2.97e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs8072100 1.000 rs8065669 chr17:45724996 G/A cg08085267 chr17:45401833 C17orf57 -0.43 -5.58 -0.32 5.97e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2415984 0.579 rs61993338 chr14:46969142 T/C cg14871534 chr14:47121158 RPL10L -0.35 -5.23 -0.31 3.52e-7 Number of children ever born; CESC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.35 5.71 0.33 3.08e-8 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25533943 chr17:43325323 LOC100133991 0.58 6.43 0.37 5.94e-10 Gut microbiome composition (summer); CESC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg11764359 chr7:65958608 NA -0.73 -10.48 -0.54 1.01e-21 Aortic root size; CESC cis rs4853012 0.887 rs6737314 chr2:74339586 A/G cg01017244 chr2:74357527 NA 0.53 6.96 0.39 2.68e-11 Gestational age at birth (maternal effect); CESC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg17724175 chr1:150552817 MCL1 0.45 7.33 0.41 2.83e-12 Tonsillectomy; CESC cis rs684232 0.602 rs8064796 chr17:525937 A/C cg12384639 chr17:618140 VPS53 0.42 5.42 0.32 1.32e-7 Prostate cancer; CESC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg07507251 chr3:52567010 NT5DC2 0.32 5.64 0.33 4.4e-8 Electroencephalogram traits; CESC cis rs4727027 0.933 rs9718383 chr7:148857624 A/T cg23158103 chr7:148848205 ZNF398 0.42 6.73 0.38 1.04e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4803468 1.000 rs1043413 chr19:41939297 C/G cg09537434 chr19:41945824 ATP5SL 1.06 19.78 0.77 4.24e-54 Height; CESC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg11890956 chr21:40555474 PSMG1 -0.94 -14.72 -0.67 2.99e-36 Cognitive function; CESC cis rs3733585 0.683 rs13112015 chr4:9933796 C/T cg02734326 chr4:10020555 SLC2A9 -0.4 -5.87 -0.34 1.28e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg26597838 chr10:835615 NA 1.2 11.12 0.56 7.74e-24 Eosinophil percentage of granulocytes; CESC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg11764359 chr7:65958608 NA -0.71 -9.33 -0.5 4.44e-18 Aortic root size; CESC cis rs9733 0.744 rs12125650 chr1:150760174 A/G cg22823121 chr1:150693482 HORMAD1 -0.38 -5.76 -0.33 2.33e-8 Tonsillectomy; CESC cis rs17253792 0.822 rs45501402 chr14:56140115 C/T cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC trans rs116095464 0.558 rs56127718 chr5:270273 G/T cg00938859 chr5:1591904 SDHAP3 0.63 6.88 0.39 4.31e-11 Breast cancer; CESC cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg03709012 chr19:19516395 GATAD2A 1.02 15.3 0.68 2.7e-38 Tonsillectomy; CESC cis rs644799 0.965 rs10831430 chr11:95509638 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.63 0.38 1.82e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9916302 0.904 rs755500 chr17:37409865 C/T cg07936489 chr17:37558343 FBXL20 -0.76 -10.43 -0.54 1.43e-21 Glomerular filtration rate (creatinine); CESC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg05535760 chr7:792225 HEATR2 0.97 11.19 0.57 4.78e-24 Cerebrospinal P-tau181p levels; CESC cis rs8062405 1.000 rs4788095 chr16:28831359 T/C cg08761264 chr16:28874980 SH2B1 -0.47 -5.84 -0.34 1.55e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9905704 0.624 rs4932691 chr17:57094617 T/C cg12560992 chr17:57184187 TRIM37 -0.61 -7.57 -0.42 6.31e-13 Testicular germ cell tumor; CESC cis rs6542838 0.641 rs13005124 chr2:99527680 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.5 -6.19 -0.36 2.25e-9 Fear of minor pain; CESC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg11494091 chr17:61959527 GH2 0.72 12.33 0.6 6.37e-28 Prudent dietary pattern; CESC cis rs644799 1.000 rs651445 chr11:95539122 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg08027265 chr7:2291960 NA -0.34 -5.13 -0.3 5.48e-7 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06120425 chr2:148602075 ACVR2A 0.6 7.13 0.4 9.69e-12 Gut microbiome composition (summer); CESC cis rs2594989 0.943 rs2594995 chr3:11369117 A/G cg00170343 chr3:11313890 ATG7 -0.55 -5.1 -0.3 6.42e-7 Circulating chemerin levels; CESC cis rs4899554 0.509 rs78368951 chr14:75730348 A/G cg18117039 chr14:75741733 NA 0.45 5.84 0.34 1.49e-8 Inflammatory bowel disease; CESC cis rs10779751 0.734 rs2791650 chr1:11132541 G/C cg08854313 chr1:11322531 MTOR 0.76 10.24 0.53 5.91e-21 Body mass index; CESC cis rs863345 0.604 rs12025831 chr1:158496282 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.87 -0.39 4.55e-11 Pneumococcal bacteremia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05468429 chr6:7248862 RREB1 -0.53 -6.33 -0.36 1.05e-9 Gut microbiome composition (summer); CESC cis rs7210086 0.948 rs72849448 chr17:70638323 C/A cg04206342 chr17:70636940 NA -0.35 -6.01 -0.35 6.05e-9 Ulcerative colitis; CESC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg07507251 chr3:52567010 NT5DC2 0.33 5.69 0.33 3.36e-8 Electroencephalogram traits; CESC cis rs34172651 0.876 rs2547033 chr16:24743657 C/T cg06028605 chr16:24865363 SLC5A11 0.4 6.18 0.36 2.37e-9 Intelligence (multi-trait analysis); CESC cis rs9616064 0.531 rs867212 chr22:47063330 C/T cg25730555 chr22:47059586 GRAMD4 -0.48 -6.29 -0.36 1.3e-9 Urate levels in obese individuals; CESC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg27286337 chr10:134555280 INPP5A 0.68 8.0 0.44 3.93e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs796364 0.760 rs2881594 chr2:201026183 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.74 -6.24 -0.36 1.76e-9 Schizophrenia; CESC cis rs62432291 0.681 rs3003173 chr6:159665692 G/T cg14500486 chr6:159655392 FNDC1 -0.65 -6.12 -0.35 3.27e-9 Joint mobility (Beighton score); CESC cis rs2073300 0.609 rs6132610 chr20:23403987 C/T cg16736954 chr20:23401023 NAPB 0.78 5.69 0.33 3.37e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs5758659 1.000 rs5758677 chr22:42643039 A/C cg15557168 chr22:42548783 NA -0.49 -7.75 -0.43 1.92e-13 Cognitive function; CESC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg13798912 chr7:905769 UNC84A -0.56 -5.53 -0.32 7.82e-8 Cerebrospinal P-tau181p levels; CESC cis rs6121246 0.909 rs6119725 chr20:30385557 G/T cg13852791 chr20:30311386 BCL2L1 0.81 8.61 0.47 6.48e-16 Mean corpuscular hemoglobin; CESC cis rs7605827 0.930 rs7588148 chr2:15706392 G/A cg19274914 chr2:15703543 NA 0.36 6.47 0.37 4.83e-10 Educational attainment (years of education); CESC cis rs3126085 1.000 rs72698906 chr1:152307184 G/A cg03465714 chr1:152285911 FLG 0.48 5.45 0.32 1.17e-7 Atopic dermatitis; CESC cis rs2191566 0.648 rs62115511 chr19:44583289 T/C cg20607764 chr19:44506953 ZNF230 -0.42 -5.33 -0.31 2.09e-7 Acute lymphoblastic leukemia (childhood); CESC trans rs561341 1.000 rs55643307 chr17:30263074 T/C cg20587970 chr11:113659929 NA -1.43 -17.68 -0.74 9.48e-47 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08252855 chr14:24550926 NRL 0.54 6.64 0.38 1.75e-10 Gut microbiome composition (summer); CESC cis rs8020095 0.528 rs1955604 chr14:67436440 G/C cg19548862 chr14:67692701 FAM71D -0.48 -5.72 -0.33 2.86e-8 Depression (quantitative trait); CESC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.51e-24 Menopause (age at onset); CESC cis rs372883 0.600 rs2832294 chr21:30739671 A/C cg24692254 chr21:30365293 RNF160 0.58 7.23 0.41 5.32e-12 Pancreatic cancer; CESC cis rs9943753 0.508 rs5013021 chr12:109790752 C/A cg19025524 chr12:109796872 NA -0.48 -6.9 -0.39 3.9e-11 HDL cholesterol; CESC cis rs9486719 0.947 rs6916232 chr6:96985959 A/T cg18709589 chr6:96969512 KIAA0776 0.55 6.31 0.36 1.18e-9 Migraine;Coronary artery disease; CESC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.55 7.35 0.41 2.47e-12 Lymphocyte counts; CESC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg11764359 chr7:65958608 NA -0.78 -11.17 -0.57 5.37e-24 Aortic root size; CESC cis rs8060686 0.858 rs8057986 chr16:67893879 A/G cg26727032 chr16:67993705 SLC12A4 -0.66 -9.63 -0.51 5.27e-19 HDL cholesterol;Metabolic syndrome; CESC cis rs9318086 0.712 rs9510917 chr13:24442846 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.39 5.25 0.31 3.17e-7 Myopia (pathological); CESC cis rs67311347 0.911 rs6776044 chr3:40377503 T/G cg09455208 chr3:40491958 NA 0.49 8.42 0.46 2.47e-15 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19121055 chr22:20307793 DGCR6L 0.55 6.22 0.36 1.89e-9 Gut microbiome composition (summer); CESC cis rs41271473 0.526 rs10916344 chr1:228737489 C/T cg10167378 chr1:228756711 NA 0.51 5.28 0.31 2.73e-7 Chronic lymphocytic leukemia; CESC trans rs1728785 0.901 rs1631910 chr16:68603335 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 8.03 0.44 3.13e-14 Ulcerative colitis; CESC cis rs7827545 0.644 rs4909452 chr8:135521053 C/G cg17885191 chr8:135476712 NA -0.56 -7.58 -0.42 5.86e-13 Hypertension (SNP x SNP interaction); CESC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg03609598 chr5:56110824 MAP3K1 0.52 5.62 0.33 4.84e-8 Initial pursuit acceleration; CESC cis rs10484885 0.878 rs55750696 chr6:90552336 G/A cg13799429 chr6:90582589 CASP8AP2 -0.76 -7.22 -0.41 5.66e-12 QRS interval (sulfonylurea treatment interaction); CESC cis rs644799 1.000 rs627568 chr11:95569253 A/C cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.64 0.47 5.31e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7927592 0.913 rs6591346 chr11:68384618 T/A cg20283391 chr11:68216788 NA -0.47 -5.97 -0.34 7.58e-9 Total body bone mineral density; CESC cis rs929354 0.772 rs3802123 chr7:156970641 G/A cg05182265 chr7:156933206 UBE3C -0.46 -6.6 -0.38 2.29e-10 Body mass index; CESC cis rs7537660 0.866 rs4925738 chr1:248005613 G/T cg12080717 chr1:248004886 OR11L1 -0.43 -5.27 -0.31 2.88e-7 Platelet distribution width; CESC cis rs2635047 0.624 rs2289036 chr18:44595809 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.5 -6.96 -0.39 2.69e-11 Educational attainment; CESC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg17376030 chr22:41985996 PMM1 -0.78 -8.33 -0.46 4.43e-15 Vitiligo; CESC cis rs1538970 0.810 rs12067642 chr1:45927517 G/T cg05343316 chr1:45956843 TESK2 0.84 11.95 0.59 1.29e-26 Platelet count; CESC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg11644478 chr21:40555479 PSMG1 0.98 14.24 0.66 1.45e-34 Cognitive function; CESC cis rs5769707 0.732 rs135865 chr22:50004829 G/A cg05373962 chr22:49881684 NA -0.39 -6.51 -0.37 3.69e-10 Monocyte count;Monocyte percentage of white cells; CESC trans rs9325144 0.560 rs61929893 chr12:38653366 G/A cg23762105 chr12:34175262 ALG10 0.48 6.31 0.36 1.15e-9 Morning vs. evening chronotype; CESC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.05e-8 Lung cancer; CESC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg20151795 chr6:28129481 ZNF389 0.44 5.59 0.33 5.5e-8 Depression; CESC cis rs2439831 0.717 rs9806227 chr15:43680115 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.91 11.14 0.56 6.61e-24 Lung cancer in ever smokers; CESC trans rs10028773 0.600 rs4001390 chr4:120265783 G/C cg25214090 chr10:38739885 LOC399744 0.59 8.14 0.45 1.55e-14 Educational attainment; CESC cis rs728616 0.614 rs57342950 chr10:82105081 G/A cg05935833 chr10:81318306 SFTPA2 -0.37 -5.22 -0.31 3.54e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18510056 chr10:77163383 C10orf41 -0.69 -8.74 -0.47 2.79e-16 Gut microbiome composition (summer); CESC cis rs7208859 0.673 rs61223749 chr17:29163747 G/A cg19761014 chr17:28927070 LRRC37B2 0.72 5.68 0.33 3.48e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11098499 0.738 rs28687057 chr4:120280812 A/G cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06905471 chr2:29092871 TRMT61B -0.53 -8.04 -0.44 3.02e-14 Gambling; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg20490126 chr1:25870007 LDLRAP1 0.52 6.76 0.38 9.02e-11 Breast cancer;Type 2 diabetes; CESC cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.7 8.69 0.47 3.79e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs2404602 0.716 rs67920045 chr15:76800084 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.71 -0.33 3.04e-8 Blood metabolite levels; CESC cis rs4629180 0.675 rs6742474 chr2:102091075 G/A cg04415270 chr2:102091202 RFX8 -0.33 -5.59 -0.32 5.72e-8 Chronic rhinosinusitis with nasal polyps; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02473084 chr2:37551451 NA 0.68 7.87 0.44 9.06e-14 Gut microbiome composition (summer); CESC cis rs61542988 0.570 rs10950919 chr7:22833821 A/G cg11367502 chr7:22862612 TOMM7 0.54 6.48 0.37 4.33e-10 Fibrinogen levels; CESC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg07701084 chr6:150067640 NUP43 0.44 6.15 0.35 2.83e-9 Lung cancer; CESC cis rs1505368 0.789 rs13419353 chr2:213271459 A/T cg16329650 chr2:213403929 ERBB4 -0.41 -5.77 -0.33 2.15e-8 Symmetrical dimethylarginine levels; CESC cis rs9915657 0.933 rs17246133 chr17:70140485 A/G cg09344028 chr17:70110421 NA 0.3 5.68 0.33 3.51e-8 Thyroid hormone levels; CESC cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg03433033 chr1:76189801 ACADM 0.63 6.24 0.36 1.68e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg02297831 chr4:17616191 MED28 0.44 5.37 0.31 1.73e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg08027265 chr7:2291960 NA -0.45 -6.96 -0.39 2.71e-11 Bipolar disorder and schizophrenia; CESC trans rs1814175 0.519 rs10839291 chr11:49514321 G/A cg15704280 chr7:45808275 SEPT13 0.82 9.88 0.52 8.15e-20 Height; CESC cis rs2197308 0.623 rs1672426 chr12:38118671 C/T cg26384229 chr12:38710491 ALG10B -0.42 -5.75 -0.33 2.5e-8 Morning vs. evening chronotype; CESC cis rs3845702 0.736 rs72962517 chr2:180861452 G/A cg01881094 chr2:180872142 CWC22 1.08 9.4 0.5 2.75e-18 Schizophrenia; CESC cis rs6942756 1.000 rs68076553 chr7:128959632 A/G cg02491457 chr7:128862824 NA -0.66 -8.95 -0.48 6.38e-17 White matter hyperintensity burden; CESC cis rs4132509 1.000 rs6675851 chr1:243787494 G/A cg21452805 chr1:244014465 NA 0.43 5.06 0.3 7.8e-7 RR interval (heart rate); CESC trans rs10905099 0.708 rs11254970 chr10:7094554 G/A cg05230642 chr15:25439252 SNORD115-14 -0.73 -6.17 -0.35 2.6e-9 Orofacial clefts; CESC trans rs17125944 0.615 rs2025633 chr14:53317340 C/T cg01134794 chr4:78529898 CXCL13 0.54 6.2 0.36 2.13e-9 Alzheimer's disease (late onset); CESC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg21433313 chr16:3507492 NAT15 -0.61 -6.71 -0.38 1.16e-10 Tuberculosis; CESC cis rs425277 0.585 rs3128294 chr1:2065343 G/C cg23803603 chr1:2058230 PRKCZ -0.31 -5.08 -0.3 7.14e-7 Height; CESC cis rs9814567 1.000 rs1874883 chr3:134205071 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.22 -0.36 1.92e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg20151795 chr6:28129481 ZNF389 0.46 5.74 0.33 2.6e-8 Depression; CESC cis rs965469 1.000 rs2236089 chr20:3257194 C/A cg25506879 chr20:3388711 C20orf194 -0.59 -6.27 -0.36 1.48e-9 IFN-related cytopenia; CESC cis rs7833986 0.501 rs72653948 chr8:56955689 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.6 7.34 0.41 2.58e-12 Height; CESC cis rs7084402 0.967 rs2114564 chr10:60314729 T/C cg07615347 chr10:60278583 BICC1 0.58 8.82 0.48 1.52e-16 Refractive error; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00745731 chr19:929724 ARID3A 0.45 6.29 0.36 1.34e-9 Fibrinogen levels; CESC cis rs7000551 0.751 rs2461490 chr8:22370115 G/C cg12081754 chr8:22256438 SLC39A14 0.39 5.19 0.3 4.1e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs1950626 0.750 rs12895798 chr14:101442793 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.83 11.29 0.57 2.14e-24 Pelvic organ prolapse (moderate/severe); CESC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg19193384 chr17:30244184 NA -0.66 -6.97 -0.39 2.5e-11 Hip circumference adjusted for BMI; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19655070 chr17:43237981 HEXIM2 -0.44 -6.06 -0.35 4.74e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs17384381 0.953 rs1498374 chr1:85787334 C/T cg16011679 chr1:85725395 C1orf52 0.79 7.98 0.44 4.35e-14 Lobe attachment (rater-scored or self-reported); CESC trans rs3808502 0.549 rs11991139 chr8:11428395 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -6.51 -0.37 3.71e-10 Neuroticism; CESC trans rs10435719 0.867 rs34465618 chr8:11791356 C/T cg15556689 chr8:8085844 FLJ10661 0.52 6.35 0.36 9.52e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.93 0.34 9.3e-9 Tonsillectomy; CESC cis rs11252926 0.801 rs11252332 chr10:467318 A/T cg18196295 chr10:418757 DIP2C 0.47 5.63 0.33 4.51e-8 Psychosis in Alzheimer's disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg10869376 chr13:41345315 MRPS31 0.46 6.12 0.35 3.44e-9 Systemic lupus erythematosus; CESC cis rs9915657 0.870 rs11077595 chr17:70130030 C/T cg06234051 chr17:70120541 SOX9 -0.44 -6.38 -0.37 7.69e-10 Thyroid hormone levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09093137 chr7:105028539 SRPK2 -0.49 -7.41 -0.41 1.71e-12 Gambling; CESC cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg15052019 chr19:19431593 KIAA0892;SF4 -0.42 -5.31 -0.31 2.38e-7 Tonsillectomy; CESC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg22508957 chr16:3507546 NAT15 0.68 8.58 0.47 7.9e-16 Tuberculosis; CESC cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg27398817 chr8:82754497 SNX16 -0.42 -5.25 -0.31 3.13e-7 Diastolic blood pressure; CESC cis rs826838 0.967 rs1352122 chr12:39130885 G/A cg26384229 chr12:38710491 ALG10B -0.67 -11.03 -0.56 1.63e-23 Heart rate; CESC cis rs10751667 0.643 rs7396623 chr11:934104 G/A cg06064525 chr11:970664 AP2A2 -0.49 -9.61 -0.51 5.84e-19 Alzheimer's disease (late onset); CESC cis rs7827545 0.960 rs1372661 chr8:135566859 A/G cg17885191 chr8:135476712 NA 0.48 6.28 0.36 1.35e-9 Hypertension (SNP x SNP interaction); CESC cis rs2404602 0.647 rs116090606 chr15:77075209 A/G cg23625390 chr15:77176239 SCAPER -0.47 -6.5 -0.37 3.86e-10 Blood metabolite levels; CESC cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg04455712 chr21:45112962 RRP1B -0.46 -7.39 -0.41 1.94e-12 Mean corpuscular volume; CESC cis rs7843479 1.000 rs2306641 chr8:21833965 A/G cg17168535 chr8:21777572 XPO7 -0.48 -6.73 -0.38 1.02e-10 Mean corpuscular volume; CESC cis rs681343 1.000 rs679574 chr19:49206108 C/G cg21064579 chr19:49206444 FUT2 0.52 7.36 0.41 2.36e-12 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CESC trans rs2415984 0.818 rs10149370 chr14:46850711 T/C cg14945696 chr3:52713679 PBRM1 -0.4 -6.19 -0.36 2.32e-9 Number of children ever born; CESC cis rs34779708 0.966 rs34776628 chr10:35426324 G/A cg04310649 chr10:35416472 CREM -0.52 -6.45 -0.37 5.15e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs9287719 0.753 rs1990613 chr2:10781975 C/T cg00105475 chr2:10696890 NA -0.34 -5.23 -0.31 3.46e-7 Prostate cancer; CESC cis rs11792861 0.855 rs116127510 chr9:111868344 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.41 5.15 0.3 5.08e-7 Menarche (age at onset); CESC cis rs4901847 0.562 rs11627221 chr14:58617216 G/T cg15908186 chr14:58618357 C14orf37 0.37 5.75 0.33 2.5e-8 Lupus nephritis in systemic lupus erythematosus; CESC cis rs9303401 0.659 rs35928756 chr17:56702652 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.03 13.13 0.63 1.12e-30 Cognitive test performance; CESC cis rs3820068 0.603 rs6429767 chr1:15963334 G/A cg17385448 chr1:15911702 AGMAT 0.42 6.89 0.39 4.06e-11 Systolic blood pressure; CESC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg04267008 chr7:1944627 MAD1L1 0.56 6.57 0.37 2.66e-10 Bipolar disorder and schizophrenia; CESC cis rs5758659 0.622 rs129856 chr22:42399396 C/G cg15557168 chr22:42548783 NA -0.43 -6.3 -0.36 1.22e-9 Cognitive function; CESC trans rs11039798 1.000 rs10838942 chr11:48557163 C/G cg15704280 chr7:45808275 SEPT13 0.7 6.53 0.37 3.42e-10 Axial length; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05463257 chr3:182782445 MCCC1 -0.46 -6.32 -0.36 1.07e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs644799 0.930 rs2186782 chr11:95649543 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.8 11.62 0.58 1.66e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1538970 0.847 rs1771550 chr1:45883565 C/T cg24296786 chr1:45957014 TESK2 0.44 5.41 0.32 1.4e-7 Platelet count; CESC cis rs2479106 0.549 rs7855648 chr9:126380439 A/G cg16191174 chr9:126692580 DENND1A 0.38 5.32 0.31 2.2e-7 Polycystic ovary syndrome; CESC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg24675658 chr1:53192096 ZYG11B -0.52 -6.6 -0.38 2.19e-10 Monocyte count; CESC cis rs7937682 0.924 rs7938360 chr11:111539875 A/G cg22437258 chr11:111473054 SIK2 0.69 9.16 0.49 1.44e-17 Primary sclerosing cholangitis; CESC cis rs2710642 0.611 rs1843779 chr2:62866762 T/C cg17519650 chr2:63277830 OTX1 0.47 5.54 0.32 7.36e-8 LDL cholesterol levels;LDL cholesterol; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27512018 chr19:11039304 YIPF2;C19orf52 -0.44 -6.81 -0.39 6.33e-11 Gambling; CESC cis rs34638686 1 rs34638686 chr3:48682658 C/T cg07636037 chr3:49044803 WDR6 -0.66 -5.19 -0.3 4.09e-7 Educational attainment (years of education); CESC cis rs7103648 0.864 rs10742802 chr11:47432725 T/G cg03711944 chr11:47377212 SPI1 -0.31 -5.04 -0.3 8.72e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg09324608 chr17:30823087 MYO1D 0.49 7.3 0.41 3.46e-12 Schizophrenia; CESC cis rs9896933 0.623 rs77166830 chr17:80833525 T/C cg20578329 chr17:80767326 TBCD -0.75 -7.78 -0.43 1.62e-13 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs7809950 0.678 rs75617662 chr7:107030439 G/A cg23024343 chr7:107201750 COG5 -0.58 -7.26 -0.41 4.42e-12 Coronary artery disease; CESC cis rs6430585 0.528 rs309161 chr2:136688749 A/G cg07169764 chr2:136633963 MCM6 -1.06 -14.93 -0.68 5.44e-37 Corneal structure; CESC cis rs7208859 0.623 rs73269945 chr17:29108759 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg25072359 chr17:41440525 NA 0.52 7.74 0.43 2.12e-13 Menopause (age at onset); CESC cis rs2637266 0.783 rs846634 chr10:78535323 C/A cg18941641 chr10:78392320 NA 0.42 8.31 0.45 5.01e-15 Pulmonary function; CESC cis rs4930103 1.000 rs4929983 chr11:2024579 C/T cg23202291 chr11:1979235 NA 0.37 5.61 0.33 4.99e-8 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg01988459 chr11:68622903 NA -0.43 -5.76 -0.33 2.38e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8070128 0.600 rs8071238 chr17:17900990 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.62 8.75 0.47 2.51e-16 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25589956 chr3:186545102 NA 0.53 6.21 0.36 2.02e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19901472 chr1:29557379 MECR -0.56 -6.15 -0.35 2.8e-9 Gut microbiome composition (summer); CESC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg18876405 chr7:65276391 NA 0.52 6.87 0.39 4.49e-11 Aortic root size; CESC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg23281280 chr6:28129359 ZNF389 0.5 6.94 0.39 3.07e-11 Depression; CESC cis rs747782 0.646 rs17198158 chr11:47477849 A/G cg25783544 chr11:47291846 MADD 0.52 5.13 0.3 5.6e-7 Intraocular pressure; CESC cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg27347728 chr4:17578864 LAP3 0.43 5.04 0.3 8.51e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1215050 0.740 rs1214994 chr4:99035577 C/T cg17366294 chr4:99064904 C4orf37 0.4 5.17 0.3 4.54e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs55883249 1.000 rs17453724 chr2:9764001 A/G cg23886495 chr2:9695866 ADAM17 0.61 5.51 0.32 8.34e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs9811920 0.799 rs9832134 chr3:99836722 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.42 5.18 0.3 4.32e-7 Axial length; CESC cis rs116095464 0.558 rs10043002 chr5:226753 G/A cg22857025 chr5:266934 NA -1.28 -18.58 -0.75 6.78e-50 Breast cancer; CESC cis rs2455799 0.574 rs2455798 chr3:15700505 G/C cg16303742 chr3:15540471 COLQ -0.39 -6.06 -0.35 4.71e-9 Mean platelet volume; CESC cis rs8077577 0.562 rs8081042 chr17:18199067 C/G cg16794390 chr17:18148240 FLII 0.41 6.44 0.37 5.57e-10 Obesity-related traits; CESC trans rs7672847 0.547 rs72973034 chr4:170369366 A/G cg19308436 chr1:237949471 RYR2 0.6 6.27 0.36 1.46e-9 Subjective well-being; CESC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.42 -0.32 1.31e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg24675658 chr1:53192096 ZYG11B -0.52 -6.43 -0.37 5.97e-10 Monocyte count; CESC cis rs6032067 0.929 rs55726011 chr20:43855229 C/T cg10761708 chr20:43804764 PI3 0.5 6.15 0.35 2.83e-9 Blood protein levels; CESC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg18876405 chr7:65276391 NA 0.52 6.87 0.39 4.49e-11 Aortic root size; CESC cis rs2243480 0.901 rs313808 chr7:65499873 T/G cg13147721 chr7:65941812 NA -0.86 -8.3 -0.45 5.53e-15 Diabetic kidney disease; CESC cis rs9488822 0.676 rs4354188 chr6:116327936 T/C cg18764771 chr6:116381957 FRK 0.22 5.42 0.32 1.35e-7 Cholesterol, total;LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21830480 chr12:72057690 THAP2;ZFC3H1 -0.69 -7.87 -0.44 9.06e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00903962 chr6:26056695 HIST1H1C 0.58 6.74 0.38 9.9e-11 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg24531977 chr5:56204891 C5orf35 -0.88 -11.2 -0.57 4.22e-24 Initial pursuit acceleration; CESC cis rs10751667 0.600 rs7394783 chr11:1005108 C/T cg20946044 chr11:1010712 AP2A2 0.53 7.3 0.41 3.29e-12 Alzheimer's disease (late onset); CESC cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg17294928 chr15:75287854 SCAMP5 0.64 6.9 0.39 3.93e-11 Blood trace element (Zn levels); CESC cis rs12618769 0.652 rs17513468 chr2:99235169 T/G cg10123293 chr2:99228465 UNC50 0.4 5.42 0.32 1.35e-7 Bipolar disorder; CESC cis rs2479106 0.727 rs10986139 chr9:126689150 C/G cg16191174 chr9:126692580 DENND1A 0.51 6.13 0.35 3.1e-9 Polycystic ovary syndrome; CESC cis rs6121246 0.512 rs6060938 chr20:30363645 T/C cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Mean corpuscular hemoglobin; CESC cis rs9487051 0.676 rs9372208 chr6:109596168 A/G cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC trans rs4824093 0.535 rs73441802 chr22:50273916 G/A cg09872104 chr7:134855509 C7orf49 -0.95 -6.67 -0.38 1.52e-10 Amyotrophic lateral sclerosis (sporadic); CESC cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg12718519 chr1:2058417 PRKCZ 0.26 5.68 0.33 3.57e-8 Height; CESC trans rs9319321 0.571 rs1927509 chr13:27414894 C/A cg14332112 chr6:47277683 TNFRSF21 -0.49 -6.25 -0.36 1.67e-9 Asthma (toluene diisocyanate-induced); CESC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs80130819 0.748 rs901962 chr12:48741219 A/T cg05342945 chr12:48394962 COL2A1 -0.51 -5.46 -0.32 1.09e-7 Prostate cancer; CESC cis rs8002861 0.875 rs12867890 chr13:44423088 A/G cg14210620 chr13:44453864 C13orf31;CCDC122 -0.42 -5.2 -0.3 3.93e-7 Leprosy; CESC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg18032046 chr6:28092343 ZSCAN16 -0.49 -5.75 -0.33 2.48e-8 Depression; CESC cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg22590775 chr19:49891494 CCDC155 0.63 7.45 0.42 1.32e-12 Multiple sclerosis; CESC cis rs2708240 1.000 rs2708243 chr7:147580412 A/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.36 -5.99 -0.35 6.79e-9 QT interval (drug interaction); CESC cis rs2836633 0.895 rs2836598 chr21:40024758 C/G cg05519781 chr21:40033154 ERG 0.78 12.85 0.62 1.02e-29 Coronary artery disease; CESC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg08109568 chr15:31115862 NA -0.71 -9.44 -0.5 2.03e-18 Huntington's disease progression; CESC cis rs10883723 0.810 rs7094751 chr10:104274818 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.58 0.42 5.73e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg03452623 chr4:187889614 NA 0.93 18.96 0.76 2.94e-51 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.38 0.54 2.06e-21 Prudent dietary pattern; CESC cis rs2282802 0.685 rs12188849 chr5:139621570 G/A cg26211634 chr5:139558579 C5orf32 0.52 7.53 0.42 8.03e-13 Intelligence (multi-trait analysis); CESC trans rs116095464 0.558 rs10065584 chr5:253997 G/A cg00938859 chr5:1591904 SDHAP3 0.71 6.48 0.37 4.51e-10 Breast cancer; CESC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg09877947 chr5:131593287 PDLIM4 0.47 6.09 0.35 3.91e-9 Breast cancer; CESC trans rs72681920 0.881 rs28364333 chr4:100200153 C/T cg22948791 chr15:71404101 CT62 -0.54 -6.12 -0.35 3.4e-9 Alcohol dependence; CESC cis rs34779708 0.931 rs4934711 chr10:35360310 G/A cg04310649 chr10:35416472 CREM -0.52 -6.23 -0.36 1.84e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg24920358 chr1:40204285 PPIE 0.4 5.91 0.34 1.07e-8 Blood protein levels; CESC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs365132 1.000 rs365132 chr5:176378574 G/T cg16309518 chr5:176445507 NA -0.38 -5.5 -0.32 8.86e-8 Menarche and menopause (age at onset);Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05095230 chr13:50367060 KPNA3 -0.69 -8.05 -0.44 2.8e-14 Gut microbiome composition (summer); CESC cis rs8067545 0.514 rs12449662 chr17:19897845 T/C cg12073167 chr17:19770448 ULK2 -0.44 -5.03 -0.3 9.14e-7 Schizophrenia; CESC cis rs938554 0.779 rs13106991 chr4:9959011 G/A cg11266682 chr4:10021025 SLC2A9 -0.38 -5.03 -0.3 8.92e-7 Blood metabolite levels; CESC cis rs3740713 1.000 rs73438668 chr11:18456536 C/T cg23797887 chr11:18477753 LDHAL6A -0.53 -5.11 -0.3 6.1e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6582630 0.519 rs11514078 chr12:38408817 G/C cg13010199 chr12:38710504 ALG10B 0.47 5.85 0.34 1.47e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs11997175 0.603 rs11778978 chr8:33804743 G/T ch.8.33884649F chr8:33765107 NA 0.44 5.3 0.31 2.49e-7 Body mass index; CESC cis rs7605827 0.893 rs2098463 chr2:15512175 C/G cg19274914 chr2:15703543 NA 0.32 5.58 0.32 5.95e-8 Educational attainment (years of education); CESC cis rs2425143 0.730 rs2095819 chr20:34353278 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.75 -0.43 1.96e-13 Blood protein levels; CESC cis rs71277158 0.688 rs17236830 chr3:169891246 G/A cg04067573 chr3:169899625 PHC3 0.71 7.12 0.4 9.91e-12 Prostate cancer; CESC cis rs929354 0.742 rs6459734 chr7:156935454 A/G cg05182265 chr7:156933206 UBE3C -0.49 -7.04 -0.4 1.69e-11 Body mass index; CESC cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg13072238 chr3:49761600 GMPPB -0.51 -6.14 -0.35 3.03e-9 Menarche (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25228510 chr10:62538235 CDK1;CDC2 -0.43 -6.88 -0.39 4.27e-11 Gambling; CESC cis rs9473147 0.571 rs9395285 chr6:47554177 G/A cg20196966 chr6:47445060 CD2AP 0.4 5.16 0.3 4.75e-7 Platelet distribution width;Mean platelet volume; CESC trans rs3087243 0.755 rs12986861 chr2:204694952 G/A cg01841312 chr10:38069945 NA -0.38 -6.24 -0.36 1.71e-9 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg19592336 chr6:28129416 ZNF389 0.61 8.0 0.44 3.95e-14 Depression; CESC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg27535305 chr1:53392650 SCP2 -0.32 -5.29 -0.31 2.54e-7 Monocyte count; CESC trans rs11098499 0.789 rs12498994 chr4:120250818 A/C cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07150777 chr2:239996253 HDAC4 0.44 6.41 0.37 6.49e-10 Fibrinogen levels; CESC cis rs7208859 0.623 rs7223209 chr17:29107220 C/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6484504 0.532 rs10835756 chr11:31267622 C/T cg14844989 chr11:31128820 NA -0.41 -5.82 -0.34 1.73e-8 Red blood cell count; CESC cis rs853679 0.882 rs4713140 chr6:28097193 C/T cg23372001 chr6:27791640 HIST1H4J 0.55 5.03 0.3 8.86e-7 Depression; CESC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg10360139 chr7:1886902 MAD1L1 -0.4 -5.05 -0.3 8.09e-7 Bipolar disorder and schizophrenia; CESC cis rs477692 0.699 rs578932 chr10:131370724 C/A cg05714579 chr10:131428358 MGMT 0.41 5.37 0.31 1.7e-7 Response to temozolomide; CESC cis rs873946 0.586 rs12783078 chr10:134569706 C/T cg27286337 chr10:134555280 INPP5A 0.69 7.74 0.43 2.06e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4820539 0.902 rs737846 chr22:23460669 A/G cg14186256 chr22:23484241 RTDR1 0.84 15.14 0.68 9.43e-38 Bone mineral density; CESC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg03188948 chr7:1209495 NA 0.72 6.91 0.39 3.61e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs2727020 0.521 rs937430 chr11:49542457 A/G cg03929089 chr4:120376271 NA 0.72 8.45 0.46 1.91e-15 Coronary artery disease; CESC trans rs2727020 0.595 rs7924311 chr11:49507573 G/A cg03929089 chr4:120376271 NA -0.85 -13.26 -0.63 3.91e-31 Coronary artery disease; CESC cis rs2228479 0.571 rs62052183 chr16:89966921 C/A cg14709524 chr16:89940631 TCF25 0.72 5.45 0.32 1.16e-7 Skin colour saturation; CESC cis rs6430585 0.583 rs11886852 chr2:136589379 G/A cg07169764 chr2:136633963 MCM6 1.17 17.56 0.73 2.66e-46 Corneal structure; CESC cis rs6723226 0.572 rs176411 chr2:32643528 A/G cg02381751 chr2:32503542 YIPF4 0.49 6.59 0.38 2.31e-10 Intelligence (multi-trait analysis); CESC trans rs1814175 0.616 rs10769644 chr11:49987676 C/A cg03929089 chr4:120376271 NA -0.92 -15.24 -0.68 4.38e-38 Height; CESC cis rs2953174 0.720 rs2975794 chr2:241515813 C/T cg07929629 chr2:241523174 NA 0.56 6.3 0.36 1.22e-9 Bipolar disorder; CESC cis rs300703 0.935 rs300749 chr2:208143 G/T cg21211680 chr2:198530 NA 0.99 8.6 0.47 7.15e-16 Blood protein levels; CESC cis rs2637266 0.667 rs2395405 chr10:78380518 C/T cg18941641 chr10:78392320 NA 0.4 7.34 0.41 2.59e-12 Pulmonary function; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21333964 chr11:118955461 HMBS 0.45 6.04 0.35 5.23e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg12963246 chr6:28129442 ZNF389 0.54 7.18 0.4 6.92e-12 Depression; CESC cis rs6088580 0.608 rs1205342 chr20:32921842 C/T cg24642439 chr20:33292090 TP53INP2 -0.52 -6.77 -0.38 8.14e-11 Glomerular filtration rate (creatinine); CESC cis rs2625529 0.526 rs7179942 chr15:72563074 C/G cg16672083 chr15:72433130 SENP8 0.43 6.46 0.37 4.88e-10 Red blood cell count; CESC cis rs13191362 0.872 rs35672319 chr6:163245464 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.24 0.31 3.3e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg08470875 chr2:26401718 FAM59B -0.48 -5.34 -0.31 2e-7 Gut microbiome composition (summer); CESC cis rs4319547 0.737 rs4758646 chr12:122946507 G/A cg05707623 chr12:122985044 ZCCHC8 -0.48 -6.03 -0.35 5.46e-9 Body mass index; CESC cis rs2996428 0.667 rs7545274 chr1:3744261 G/T cg10555106 chr1:3691387 LOC388588 0.39 5.24 0.31 3.27e-7 Red cell distribution width; CESC cis rs9467773 0.523 rs2498399 chr6:26706544 T/C cg11502198 chr6:26597334 ABT1 0.41 5.46 0.32 1.11e-7 Intelligence (multi-trait analysis); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg08884094 chr12:133286970 PGAM5 0.48 6.1 0.35 3.68e-9 Bronchopulmonary dysplasia; CESC cis rs7072216 0.763 rs10883091 chr10:100167239 C/T cg26618903 chr10:100175079 PYROXD2 -0.35 -5.38 -0.31 1.66e-7 Metabolite levels; CESC cis rs6942756 0.774 rs2566885 chr7:128917587 C/T cg02491457 chr7:128862824 NA 0.65 9.41 0.5 2.49e-18 White matter hyperintensity burden; CESC cis rs77972916 0.505 rs34247383 chr2:43532780 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.63 -5.88 -0.34 1.24e-8 Granulocyte percentage of myeloid white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14493055 chr9:88514270 NA -0.56 -6.0 -0.35 6.57e-9 Gut microbiome composition (summer); CESC cis rs11098499 0.908 rs28559989 chr4:120386627 C/T cg24375607 chr4:120327624 NA 0.44 5.48 0.32 9.91e-8 Corneal astigmatism; CESC cis rs11758351 0.660 rs11757754 chr6:26219744 A/C cg23601095 chr6:26197514 HIST1H3D 0.91 9.96 0.52 4.64e-20 Gout;Renal underexcretion gout; CESC cis rs1707322 1.000 rs785504 chr1:46595696 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.57 -0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7824557 0.628 rs7005469 chr8:11194457 G/A cg21775007 chr8:11205619 TDH 0.55 8.74 0.47 2.75e-16 Retinal vascular caliber; CESC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.66 0.43 3.59e-13 Bipolar disorder; CESC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2463822 0.858 rs2513037 chr11:62084822 A/T cg06239285 chr11:62104954 ASRGL1 -0.89 -8.97 -0.48 5.46e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs8141529 0.778 rs9625566 chr22:29162506 G/A cg02153584 chr22:29168773 CCDC117 0.68 9.78 0.51 1.77e-19 Lymphocyte counts; CESC cis rs208520 0.690 rs851459 chr6:66813989 A/G cg07460842 chr6:66804631 NA -0.98 -13.33 -0.63 2.28e-31 Exhaled nitric oxide output; CESC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.15 -0.3 5.12e-7 Life satisfaction; CESC cis rs854765 0.583 rs8070722 chr17:17813562 C/T cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.94e-9 Total body bone mineral density; CESC cis rs4481887 0.893 rs10888337 chr1:248428227 A/G cg00666640 chr1:248458726 OR2T12 -0.32 -5.59 -0.32 5.62e-8 Common traits (Other); CESC cis rs4901847 0.529 rs12895032 chr14:58618345 T/G cg15908186 chr14:58618357 C14orf37 0.4 5.96 0.34 7.94e-9 Lupus nephritis in systemic lupus erythematosus; CESC cis rs8067354 0.574 rs1292042 chr17:57934995 A/G cg02344993 chr17:57696989 CLTC 0.52 5.46 0.32 1.08e-7 Hemoglobin concentration; CESC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs11792861 0.505 rs12377869 chr9:111907803 C/A cg05043794 chr9:111880884 C9orf5 -0.31 -5.31 -0.31 2.33e-7 Menarche (age at onset); CESC cis rs2486288 0.656 rs6493145 chr15:45573862 G/T cg21132104 chr15:45694354 SPATA5L1 -0.58 -7.0 -0.4 2.07e-11 Glomerular filtration rate; CESC cis rs7851660 0.844 rs4743139 chr9:100638420 A/G cg13688889 chr9:100608707 NA -0.64 -8.94 -0.48 6.74e-17 Strep throat; CESC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.65 0.58 1.32e-25 Alzheimer's disease; CESC cis rs17376456 0.825 rs28412976 chr5:93248377 T/C cg25358565 chr5:93447407 FAM172A 1.16 9.99 0.52 3.83e-20 Diabetic retinopathy; CESC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg21770322 chr7:97807741 LMTK2 0.54 8.13 0.45 1.67e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs12822507 0.811 rs34946234 chr12:12781812 A/G cg11838227 chr12:12764436 CREBL2 -0.41 -5.33 -0.31 2.1e-7 Systemic lupus erythematosus; CESC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg11494091 chr17:61959527 GH2 0.79 14.11 0.65 4.36e-34 Prudent dietary pattern; CESC cis rs7267979 0.932 rs417130 chr20:25458320 T/C cg08601574 chr20:25228251 PYGB 0.36 5.28 0.31 2.76e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.16 0.3 4.8e-7 Bipolar disorder; CESC cis rs916888 0.773 rs199443 chr17:44819565 C/T cg17911788 chr17:44343683 NA -0.6 -7.98 -0.44 4.53e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00219956 chr16:30794205 ZNF629 0.52 7.57 0.42 6.13e-13 Fibrinogen levels; CESC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.22 0.6 1.56e-27 Alzheimer's disease; CESC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg18761221 chr20:60518478 NA 0.56 8.05 0.44 2.82e-14 Obesity-related traits; CESC cis rs9513593 1.000 rs4772186 chr13:99957987 G/A cg21788972 chr13:99853209 UBAC2 0.55 6.17 0.35 2.5e-9 Psoriasis; CESC cis rs10887741 0.646 rs1358865 chr10:89432645 C/A cg13926569 chr10:89418898 PAPSS2 0.44 6.77 0.38 8.34e-11 Exercise (leisure time); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25010622 chr20:32700257 EIF2S2 -0.46 -6.17 -0.35 2.54e-9 Ulcerative colitis; CESC cis rs5758659 0.737 rs10854749 chr22:42447341 G/T cg04733989 chr22:42467013 NAGA 0.39 5.21 0.3 3.82e-7 Cognitive function; CESC cis rs9914988 0.943 rs11656256 chr17:27153553 G/A cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs11122272 0.735 rs2808592 chr1:231523757 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs244293 0.765 rs7503269 chr17:53019712 T/C cg19360675 chr17:53046073 COX11;STXBP4 -0.45 -6.06 -0.35 4.64e-9 Menarche (age at onset); CESC cis rs10242455 0.867 rs1357319 chr7:99310181 G/T cg07715041 chr7:99302981 CYP3A7 0.43 5.46 0.32 1.12e-7 Blood metabolite levels; CESC cis rs7089973 0.604 rs17663670 chr10:116596269 A/C cg23260525 chr10:116636907 FAM160B1 -0.4 -7.44 -0.42 1.4e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg16680214 chr1:154839983 KCNN3 -0.44 -6.69 -0.38 1.28e-10 Prostate cancer; CESC cis rs501120 0.929 rs2576355 chr10:44750362 A/G cg09554077 chr10:44749378 NA 0.49 6.54 0.37 3.11e-10 Coronary artery disease;Coronary heart disease; CESC cis rs3096299 0.967 rs753853 chr16:89446525 G/T cg08392591 chr16:89556376 ANKRD11 0.42 5.31 0.31 2.34e-7 Multiple myeloma (IgH translocation); CESC cis rs829880 0.570 rs844205 chr12:98846053 A/G cg25150519 chr12:98850993 NA 0.83 10.88 0.56 4.87e-23 Colonoscopy-negative controls vs population controls; CESC cis rs924607 0.510 rs1709542 chr5:662543 A/G cg07001201 chr5:642380 CEP72 -0.39 -5.38 -0.31 1.61e-7 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs3857536 0.813 rs1891600 chr6:66941645 G/C cg07460842 chr6:66804631 NA -0.41 -5.28 -0.31 2.71e-7 Blood trace element (Cu levels); CESC cis rs72772090 0.539 rs72773923 chr5:96117579 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.21 -0.3 3.74e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3859192 0.599 rs12451897 chr17:38179275 G/T cg17467752 chr17:38218738 THRA -0.45 -6.02 -0.35 5.83e-9 White blood cell count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03342113 chr11:61197477 CPSF7;SDHAF2 -0.47 -6.22 -0.36 1.92e-9 Ulcerative colitis; CESC cis rs1568889 1.000 rs10767693 chr11:28093926 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 13.49 0.64 6.09e-32 Bipolar disorder; CESC cis rs1348850 0.608 rs10176632 chr2:178225934 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.67 9.14 0.49 1.65e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs7246657 0.943 rs13345116 chr19:37847098 A/T cg24637308 chr11:6592297 DNHD1 0.53 6.17 0.35 2.55e-9 Coronary artery calcification; CESC cis rs9790314 0.967 rs460165 chr3:161087710 G/A cg03342759 chr3:160939853 NMD3 -0.39 -5.04 -0.3 8.63e-7 Morning vs. evening chronotype; CESC cis rs2011503 1.000 rs45556231 chr19:19654189 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC cis rs11190604 1.000 rs3750627 chr10:102275642 G/T cg07080220 chr10:102295463 HIF1AN 0.67 6.3 0.36 1.21e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs16854884 0.586 rs4613453 chr3:143735600 C/G cg06585982 chr3:143692056 C3orf58 0.51 6.96 0.39 2.68e-11 Economic and political preferences (feminism/equality); CESC cis rs12325245 0.536 rs12925676 chr16:58625326 C/T cg05725404 chr16:58534157 NDRG4 -0.63 -5.34 -0.31 2.01e-7 Schizophrenia; CESC cis rs2985684 0.947 rs1952013 chr14:50087357 C/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.49 -5.66 -0.33 4.02e-8 Carotid intima media thickness; CESC cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg00033643 chr7:134001901 SLC35B4 0.42 5.39 0.31 1.52e-7 Mean platelet volume; CESC cis rs6570726 0.967 rs9403706 chr6:145795187 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -10.5 -0.54 8.41e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg17279839 chr7:150038598 RARRES2 0.49 5.61 0.33 5.17e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs72781680 0.898 rs72788212 chr2:24087385 G/A cg08917208 chr2:24149416 ATAD2B 0.91 8.38 0.46 3.17e-15 Lymphocyte counts; CESC cis rs7520050 0.966 rs6695809 chr1:46285461 T/C cg03146154 chr1:46216737 IPP -0.47 -6.15 -0.35 2.8e-9 Red blood cell count;Reticulocyte count; CESC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg07157834 chr1:205819609 PM20D1 0.42 6.07 0.35 4.4e-9 Menarche (age at onset); CESC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg23161317 chr6:28129485 ZNF389 -0.5 -6.24 -0.36 1.68e-9 Parkinson's disease; CESC cis rs9326248 0.530 rs6589589 chr11:116932428 T/C cg01368799 chr11:117014884 PAFAH1B2 0.58 5.32 0.31 2.16e-7 Blood protein levels; CESC cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg26597838 chr10:835615 NA 1.18 11.47 0.58 5.21e-25 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg18180107 chr4:99064573 C4orf37 0.4 5.1 0.3 6.55e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg18876405 chr7:65276391 NA 0.5 6.87 0.39 4.63e-11 Aortic root size; CESC cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg14784868 chr12:69753453 YEATS4 0.84 13.62 0.64 2.29e-32 Blood protein levels; CESC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.27 0.6 1.07e-27 Alzheimer's disease; CESC cis rs2439831 0.867 rs8039638 chr15:43634405 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.73 0.55 1.57e-22 Lung cancer in ever smokers; CESC cis rs1775715 0.737 rs2151047 chr10:32102110 G/A cg18675610 chr10:32216311 ARHGAP12 0.33 5.1 0.3 6.52e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs875971 0.660 rs10950044 chr7:66042976 A/G cg26939375 chr7:64535504 NA -0.64 -8.62 -0.47 6.05e-16 Aortic root size; CESC cis rs1144333 1.000 rs5745327 chr1:76270040 A/T cg10523679 chr1:76189770 ACADM -0.58 -5.83 -0.34 1.65e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs116988415 0.584 rs11622171 chr14:65258644 C/G cg25083366 chr14:65239357 SPTB 0.72 5.11 0.3 6.32e-7 Daytime sleep phenotypes; CESC cis rs116095464 0.558 rs1541822 chr5:269234 A/C cg10591111 chr5:226296 SDHA 0.5 6.01 0.35 6.02e-9 Breast cancer; CESC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.79 0.43 1.48e-13 Prudent dietary pattern; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26823989 chr1:87380673 SEP15;HS2ST1 0.46 6.3 0.36 1.25e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05888406 chr7:5280109 NA 0.47 6.69 0.38 1.35e-10 Gut microbiota (bacterial taxa); CESC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg12463550 chr7:65579703 CRCP -0.54 -6.55 -0.37 2.91e-10 Aortic root size; CESC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg06873352 chr17:61820015 STRADA 0.72 12.84 0.62 1.18e-29 Prudent dietary pattern; CESC cis rs748404 0.697 rs505249 chr15:43559960 T/A cg27015174 chr15:43622946 ADAL;LCMT2 0.59 7.72 0.43 2.43e-13 Lung cancer; CESC cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg22535103 chr8:58192502 C8orf71 -0.65 -7.05 -0.4 1.58e-11 Developmental language disorder (linguistic errors); CESC cis rs1577917 1.000 rs12200330 chr6:86656653 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.0 -0.35 6.34e-9 Response to antipsychotic treatment; CESC cis rs367943 1.000 rs348954 chr5:112821716 A/G cg12552261 chr5:112820674 MCC -0.63 -8.02 -0.44 3.43e-14 Type 2 diabetes; CESC trans rs61931739 0.534 rs1705757 chr12:34091637 A/G cg26384229 chr12:38710491 ALG10B 0.52 7.04 0.4 1.66e-11 Morning vs. evening chronotype; CESC cis rs2075371 0.501 rs1643043 chr7:134013902 C/T cg20476274 chr7:133979776 SLC35B4 0.48 6.11 0.35 3.61e-9 Mean platelet volume; CESC trans rs6951245 0.786 rs77943789 chr7:1140158 C/T cg13565492 chr6:43139072 SRF -0.67 -6.8 -0.39 6.9e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6502050 0.799 rs6502088 chr17:80169484 C/T cg23985595 chr17:80112537 CCDC57 -0.4 -6.28 -0.36 1.41e-9 Life satisfaction; CESC cis rs6088580 0.634 rs6059824 chr20:33014543 T/C cg06115741 chr20:33292138 TP53INP2 0.47 6.02 0.35 5.82e-9 Glomerular filtration rate (creatinine); CESC cis rs1050631 1.000 rs1785916 chr18:33696156 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.44 5.67 0.33 3.75e-8 Esophageal squamous cell cancer (length of survival); CESC cis rs17253792 0.822 rs17685078 chr14:56127202 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs7223966 1.000 rs9899788 chr17:61756384 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.6 -0.33 5.23e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2933343 1.000 rs2929859 chr3:128608341 T/G cg25356066 chr3:128598488 ACAD9 0.6 7.51 0.42 9.13e-13 IgG glycosylation; CESC cis rs896854 0.517 rs9643353 chr8:95957063 A/G cg13393036 chr8:95962371 TP53INP1 0.49 9.29 0.5 5.81e-18 Type 2 diabetes; CESC cis rs7937682 0.961 rs4936682 chr11:111629743 T/G cg09085632 chr11:111637200 PPP2R1B 1.11 15.11 0.68 1.22e-37 Primary sclerosing cholangitis; CESC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.73 -0.33 2.78e-8 Total body bone mineral density; CESC cis rs9896933 0.778 rs80243549 chr17:80821485 G/T cg20578329 chr17:80767326 TBCD -0.72 -7.36 -0.41 2.26e-12 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02068989 chr1:10458939 PGD 0.64 7.2 0.4 6.25e-12 Gut microbiome composition (summer); CESC cis rs11690935 0.959 rs7586207 chr2:172671094 A/G cg13550731 chr2:172543902 DYNC1I2 -0.95 -14.48 -0.66 2.12e-35 Schizophrenia; CESC trans rs1977584 0.725 rs61853975 chr10:45392633 G/A cg09262100 chr14:103416268 CDC42BPB 0.61 6.13 0.35 3.16e-9 Selective IgA deficiency; CESC cis rs3806843 1.000 rs1548700 chr5:140164889 A/T cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.18 -0.3 4.31e-7 Depressive symptoms (multi-trait analysis); CESC trans rs1973993 0.967 rs2181375 chr1:96940119 A/G cg10631902 chr5:14652156 NA 0.5 6.7 0.38 1.28e-10 Weight; CESC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg07362569 chr17:61921086 SMARCD2 -0.35 -5.04 -0.3 8.61e-7 Prudent dietary pattern; CESC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg23985595 chr17:80112537 CCDC57 0.42 6.55 0.37 2.99e-10 Life satisfaction; CESC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 10.48 0.54 9.64e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6866344 0.570 rs4266420 chr5:178137161 C/G cg03877680 chr5:178157825 ZNF354A 0.83 10.39 0.54 1.95e-21 Neutrophil percentage of white cells; CESC cis rs2274273 1.000 rs3825613 chr14:55593172 A/C cg04306507 chr14:55594613 LGALS3 0.28 5.11 0.3 6.23e-7 Protein biomarker; CESC cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.82 0.34 1.74e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.721 rs11211151 chr1:46112752 T/C cg05343316 chr1:45956843 TESK2 0.5 6.05 0.35 4.9e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7678296 0.730 rs73126371 chr4:37227154 A/G cg06805348 chr4:37245195 KIAA1239 0.4 5.04 0.3 8.47e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs7551222 0.716 rs11240751 chr1:204462050 A/G cg20240347 chr1:204465584 NA -0.26 -5.14 -0.3 5.42e-7 Schizophrenia; CESC cis rs4919694 1.000 rs12246689 chr10:104817031 C/T cg04362960 chr10:104952993 NT5C2 0.79 7.08 0.4 1.27e-11 Arsenic metabolism; CESC cis rs938554 0.692 rs13125209 chr4:9982044 A/C cg00071950 chr4:10020882 SLC2A9 0.48 5.69 0.33 3.44e-8 Blood metabolite levels; CESC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg26855724 chr1:75198818 TYW3;CRYZ 0.52 6.84 0.39 5.33e-11 Resistin levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01484320 chr1:109757057 SARS 0.51 6.52 0.37 3.56e-10 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg03467027 chr4:99064603 C4orf37 0.43 5.44 0.32 1.24e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7116495 0.609 rs10450664 chr11:71636655 A/G cg10381502 chr11:71823885 C11orf51 -1.1 -7.08 -0.4 1.33e-11 Severe influenza A (H1N1) infection; CESC cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg27286337 chr10:134555280 INPP5A 0.63 7.16 0.4 7.94e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs7246657 1.000 rs7246657 chr19:37747108 C/T cg24637308 chr11:6592297 DNHD1 -0.52 -6.07 -0.35 4.49e-9 Coronary artery calcification; CESC cis rs10465746 0.967 rs12759527 chr1:84434425 T/C cg10977910 chr1:84465055 TTLL7 0.46 6.32 0.36 1.08e-9 Obesity-related traits; CESC cis rs921968 0.643 rs832802 chr2:219386899 C/T cg02176678 chr2:219576539 TTLL4 0.43 7.75 0.43 1.97e-13 Mean corpuscular hemoglobin concentration; CESC cis rs5769765 0.542 rs1535189 chr22:50249131 T/C cg02269571 chr22:50332266 NA 0.46 5.44 0.32 1.19e-7 Schizophrenia; CESC cis rs9486719 1.000 rs12205655 chr6:96891733 T/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg00825309 chr19:58991885 ZNF446 0.57 8.74 0.47 2.8e-16 Uric acid clearance; CESC cis rs9291683 0.530 rs17246501 chr4:9985710 A/C cg11266682 chr4:10021025 SLC2A9 0.6 11.86 0.59 2.52e-26 Bone mineral density; CESC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg26587870 chr6:27730563 NA -0.6 -5.29 -0.31 2.58e-7 Depression; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14774160 chr17:4901081 INCA1;KIF1C -0.48 -6.43 -0.37 6.02e-10 Ulcerative colitis; CESC cis rs17253792 0.915 rs77161327 chr14:56178565 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.74 5.1 0.3 6.53e-7 Putamen volume; CESC cis rs9911578 0.842 rs12450766 chr17:56832965 G/C cg12560992 chr17:57184187 TRIM37 -0.83 -11.38 -0.57 1.04e-24 Intelligence (multi-trait analysis); CESC cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg17143192 chr8:8559678 CLDN23 0.44 5.44 0.32 1.2e-7 Mood instability; CESC cis rs2425143 0.512 rs2425126 chr20:34331730 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.96e-22 Blood protein levels; CESC cis rs1707322 1.000 rs12124847 chr1:46380850 T/A cg03146154 chr1:46216737 IPP 0.79 10.79 0.55 9.83e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2576037 0.583 rs578451 chr18:44404525 T/A cg19077165 chr18:44547161 KATNAL2 -0.62 -9.34 -0.5 4.05e-18 Personality dimensions; CESC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg04772025 chr11:68637568 NA 0.5 5.95 0.34 8.36e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs950169 0.960 rs35159785 chr15:84804014 G/A cg17507749 chr15:85114479 UBE2QP1 0.6 6.65 0.38 1.7e-10 Schizophrenia; CESC cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg20503657 chr10:835505 NA 0.71 8.03 0.44 3.24e-14 Eosinophil percentage of granulocytes; CESC trans rs208520 0.661 rs7740835 chr6:66865548 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.94 -0.62 5.1e-30 Exhaled nitric oxide output; CESC cis rs2280018 0.963 rs11075255 chr16:15166232 A/G cg27102117 chr16:15229624 NA 0.5 7.86 0.43 9.89e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7771547 0.573 rs566742 chr6:36395668 C/T cg07856975 chr6:36356162 ETV7 0.36 5.31 0.31 2.31e-7 Platelet distribution width; CESC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg04369109 chr6:150039330 LATS1 -0.39 -5.44 -0.32 1.23e-7 Lung cancer; CESC cis rs2243480 1.000 rs160644 chr7:65558186 C/T cg18252515 chr7:66147081 NA -1.39 -13.81 -0.65 4.83e-33 Diabetic kidney disease; CESC cis rs10129255 0.500 rs7161740 chr14:107184358 G/T cg07958169 chr14:107095056 NA -0.53 -8.41 -0.46 2.5e-15 Kawasaki disease; CESC cis rs295140 0.605 rs159320 chr2:201187775 A/G cg23649088 chr2:200775458 C2orf69 0.47 6.31 0.36 1.15e-9 QT interval; CESC cis rs12369635 1.000 rs73159540 chr12:129559421 C/T cg01909103 chr12:129572610 TMEM132D -0.69 -5.9 -0.34 1.09e-8 Schizophrenia (inflammation and infection response interaction); CESC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg11764359 chr7:65958608 NA -0.53 -6.98 -0.39 2.34e-11 Aortic root size; CESC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg19077165 chr18:44547161 KATNAL2 -0.54 -7.98 -0.44 4.51e-14 Personality dimensions; CESC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.61e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg02034447 chr16:89574710 SPG7 0.47 5.97 0.34 7.76e-9 Multiple myeloma (IgH translocation); CESC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg02569458 chr12:86230093 RASSF9 0.57 8.34 0.46 4.13e-15 Major depressive disorder; CESC cis rs738322 0.804 rs4821742 chr22:38514839 T/C cg17652424 chr22:38574118 PLA2G6 -0.29 -5.1 -0.3 6.59e-7 Cutaneous nevi; CESC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.1 -0.35 3.69e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs889398 0.770 rs8052225 chr16:69883653 G/A cg09409435 chr16:70099608 PDXDC2 0.42 5.22 0.31 3.56e-7 Body mass index; CESC cis rs2832191 1.000 rs2832189 chr21:30487414 C/T cg08807101 chr21:30365312 RNF160 -0.67 -9.14 -0.49 1.73e-17 Dental caries; CESC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.76 0.65 7.41e-33 Prudent dietary pattern; CESC cis rs1882538 0.596 rs10281827 chr7:133081810 A/G cg10665199 chr7:133106180 EXOC4 0.6 8.33 0.46 4.28e-15 Intelligence (multi-trait analysis); CESC cis rs1559088 0.901 rs7249983 chr19:33598851 C/A cg17764715 chr19:33622953 WDR88 0.5 6.52 0.37 3.56e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.91 0.34 1.03e-8 Tonsillectomy; CESC trans rs62103177 0.513 rs9945153 chr18:77598450 C/T cg05926928 chr17:57297772 GDPD1 1.14 11.6 0.58 1.95e-25 Opioid sensitivity; CESC cis rs6963495 0.818 rs117028299 chr7:105162310 T/C cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs11190604 1.000 rs28522614 chr10:102323141 T/A cg07080220 chr10:102295463 HIF1AN 0.64 6.13 0.35 3.14e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs2204008 0.635 rs1283298 chr12:38147630 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.87 -0.34 1.28e-8 Bladder cancer; CESC cis rs12571093 0.773 rs7895164 chr10:69985415 T/C cg06988349 chr10:69991859 ATOH7 0.33 5.19 0.3 4.12e-7 Optic nerve measurement (disc area); CESC cis rs718433 0.614 rs8017132 chr14:22209363 T/C cg02257791 chr14:22217085 NA -0.34 -5.23 -0.31 3.41e-7 Intraocular pressure; CESC cis rs1003719 0.788 rs2251161 chr21:38467857 C/G cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg27427491 chr17:78079615 GAA -0.4 -5.75 -0.33 2.48e-8 Yeast infection; CESC cis rs6460942 0.915 rs62448598 chr7:12453762 T/C cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs2204008 0.777 rs11179774 chr12:38219559 A/C cg26384229 chr12:38710491 ALG10B 0.74 10.65 0.55 2.74e-22 Bladder cancer; CESC cis rs72781680 1.000 rs72781658 chr2:24220141 A/G cg20701182 chr2:24300061 SF3B14 0.81 6.9 0.39 3.82e-11 Lymphocyte counts; CESC cis rs8028313 0.504 rs338364 chr15:68173921 A/G cg26545918 chr15:68124484 LBXCOR1 0.31 5.27 0.31 2.86e-7 Obesity; CESC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg26335602 chr6:28129616 ZNF389 0.52 6.81 0.39 6.59e-11 Depression; CESC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg11905131 chr22:24372483 LOC391322 -0.86 -13.7 -0.64 1.18e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs763121 0.853 rs6001185 chr22:39052155 G/A cg06544989 chr22:39130855 UNC84B 0.49 8.52 0.46 1.22e-15 Menopause (age at onset); CESC cis rs7512552 0.839 rs12046446 chr1:150460855 T/G cg15654264 chr1:150340011 RPRD2 0.39 5.09 0.3 6.94e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg04166393 chr7:2884313 GNA12 0.61 8.24 0.45 8.02e-15 Height; CESC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg24531977 chr5:56204891 C5orf35 -0.89 -11.26 -0.57 2.62e-24 Initial pursuit acceleration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08021833 chr19:5785663 PRR22;DUS3L 0.48 6.54 0.37 3.09e-10 Fibrinogen levels; CESC cis rs926938 0.563 rs360576 chr1:115459174 A/C cg12756093 chr1:115239321 AMPD1 -0.43 -5.66 -0.33 3.88e-8 Autism; CESC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg16405210 chr4:1374714 KIAA1530 -1.0 -14.25 -0.66 1.33e-34 Longevity; CESC cis rs5753618 0.539 rs8135344 chr22:31671932 G/T cg00478049 chr22:31556069 RNF185 0.46 5.21 0.3 3.8e-7 Colorectal cancer; CESC cis rs2645694 0.651 rs2703128 chr4:77819187 C/G cg10057126 chr4:77819792 ANKRD56 0.62 8.84 0.48 1.36e-16 Emphysema distribution in smoking; CESC cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg00255919 chr5:131827918 IRF1 0.51 8.68 0.47 4.19e-16 Asthma (sex interaction); CESC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg17971929 chr21:40555470 PSMG1 1.05 15.94 0.7 1.48e-40 Cognitive function; CESC cis rs1256061 0.603 rs928554 chr14:64694195 C/T cg23250157 chr14:64679961 SYNE2 0.53 7.53 0.42 8.15e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.35 -0.31 1.86e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7918232 0.556 rs788209 chr10:27434716 G/T cg14240646 chr10:27532245 ACBD5 -0.72 -5.46 -0.32 1.12e-7 Breast cancer; CESC cis rs7193541 0.684 rs7201320 chr16:74694058 T/G cg01733217 chr16:74700730 RFWD3 1.05 20.28 0.78 7.58e-56 Multiple myeloma; CESC cis rs5753618 0.561 rs714909 chr22:31741067 G/A cg13145458 chr22:31556086 RNF185 -0.49 -5.53 -0.32 7.87e-8 Colorectal cancer; CESC cis rs7582720 1.000 rs77230711 chr2:203805552 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs1799949 0.965 rs8070179 chr17:41202688 G/A cg23758822 chr17:41437982 NA 0.95 16.4 0.71 3.22e-42 Menopause (age at onset); CESC cis rs13242816 1.000 rs13221364 chr7:116083544 C/T cg04696780 chr7:116139425 CAV2 -0.63 -5.6 -0.33 5.33e-8 P wave duration; CESC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 11.8 0.59 4.14e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7605827 0.808 rs13001585 chr2:15517790 T/C cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs559928 0.597 rs947939 chr11:63885287 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.65 5.47 0.32 1.04e-7 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs7937682 0.924 rs11213968 chr11:111527629 G/C cg22437258 chr11:111473054 SIK2 0.7 9.25 0.49 7.57e-18 Primary sclerosing cholangitis; CESC cis rs6893300 0.560 rs1019443 chr5:179207547 A/G cg14593053 chr5:179126677 CANX -0.54 -7.95 -0.44 5.46e-14 Resting heart rate; CESC cis rs73019876 0.869 rs2079062 chr19:22125212 T/G cg11619707 chr19:22235551 ZNF257 -0.29 -5.46 -0.32 1.07e-7 Testicular germ cell tumor; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18044720 chr4:87857031 AFF1 -0.52 -6.65 -0.38 1.67e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1371867 0.875 rs1660311 chr8:101330579 C/T cg11906718 chr8:101322791 RNF19A 0.53 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg13902645 chr11:5959945 NA -0.66 -7.99 -0.44 4.21e-14 DNA methylation (variation); CESC cis rs9487051 0.597 rs12664455 chr6:109590739 C/T cg01475377 chr6:109611718 NA -0.42 -5.23 -0.31 3.51e-7 Reticulocyte fraction of red cells; CESC cis rs875971 0.564 rs313804 chr7:65514622 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.49 -0.32 9.58e-8 Aortic root size; CESC trans rs57221529 0.766 rs56350081 chr5:583198 G/A cg25482853 chr8:67687455 SGK3 1.01 9.99 0.52 3.67e-20 Lung disease severity in cystic fibrosis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06549955 chr12:110434341 GIT2 -0.4 -6.13 -0.35 3.09e-9 Gambling; CESC cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg20476274 chr7:133979776 SLC35B4 0.65 9.43 0.5 2.11e-18 Mean platelet volume; CESC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01159149 chr11:10830970 EIF4G2 -0.45 -6.62 -0.38 1.96e-10 Gambling; CESC trans rs9951602 0.512 rs12455566 chr18:76655926 A/G cg02800362 chr5:177631904 HNRNPAB 0.65 8.51 0.46 1.31e-15 Obesity-related traits; CESC cis rs1008375 1.000 rs4698200 chr4:17657051 G/A cg02297831 chr4:17616191 MED28 0.53 6.64 0.38 1.76e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs5750830 0.645 rs4821890 chr22:39777523 G/A cg01416388 chr22:39784598 NA -0.49 -6.68 -0.38 1.38e-10 Intelligence (multi-trait analysis); CESC cis rs6963495 0.651 rs3892298 chr7:105152187 A/G cg19920283 chr7:105172520 RINT1 0.67 6.36 0.36 8.79e-10 Bipolar disorder (body mass index interaction); CESC cis rs672059 0.966 rs492228 chr1:183156476 T/C ch.1.3577855R chr1:183094577 LAMC1 0.54 6.99 0.39 2.28e-11 Hypertriglyceridemia; CESC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg07701084 chr6:150067640 NUP43 0.48 6.75 0.38 9.54e-11 Lung cancer; CESC cis rs9911578 0.967 rs12938821 chr17:56959422 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.29 0.31 2.53e-7 Intelligence (multi-trait analysis); CESC cis rs17818399 0.533 rs13420857 chr2:46798005 C/G cg02822958 chr2:46747628 ATP6V1E2 -0.44 -5.82 -0.34 1.71e-8 Height; CESC cis rs5167 0.525 rs11083752 chr19:45454363 G/A cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.51e-10 Blood protein levels; CESC cis rs1957429 0.901 rs1951491 chr14:65346950 G/A cg23373153 chr14:65346875 NA 0.96 11.51 0.58 4.06e-25 Pediatric areal bone mineral density (radius); CESC cis rs7927592 0.956 rs12281742 chr11:68303629 C/T cg20283391 chr11:68216788 NA 0.47 6.05 0.35 4.94e-9 Total body bone mineral density; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23209537 chr7:5463409 TNRC18 -0.45 -6.07 -0.35 4.49e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12530845 0.887 rs73725434 chr7:135313657 T/C cg23117316 chr7:135346802 PL-5283 -0.48 -5.83 -0.34 1.58e-8 Red blood cell traits; CESC cis rs2304206 0.614 rs12104272 chr19:50148052 A/G cg09250473 chr19:50168907 IRF3;BCL2L12 -0.59 -7.21 -0.4 5.95e-12 Vitiligo; CESC trans rs66573146 0.901 rs55882710 chr4:7030704 G/A cg07817883 chr1:32538562 TMEM39B 1.09 6.46 0.37 4.88e-10 Granulocyte percentage of myeloid white cells; CESC cis rs2933343 0.601 rs1680759 chr3:128594896 C/G cg25356066 chr3:128598488 ACAD9 0.63 8.81 0.48 1.64e-16 IgG glycosylation; CESC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg17724175 chr1:150552817 MCL1 -0.43 -7.03 -0.4 1.76e-11 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10261819 chr16:22448417 RRN3P3;LOC641298 -0.49 -6.42 -0.37 6.21e-10 Fibrinogen levels; CESC cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg02873098 chr16:4524103 NMRAL1;HMOX2 0.35 5.12 0.3 5.88e-7 Schizophrenia; CESC cis rs8141529 0.732 rs3788409 chr22:29198151 T/G cg02153584 chr22:29168773 CCDC117 0.69 9.81 0.52 1.43e-19 Lymphocyte counts; CESC cis rs2243480 1.000 rs937108 chr7:65428452 G/A cg25894440 chr7:65020034 NA -0.63 -5.6 -0.33 5.4e-8 Diabetic kidney disease; CESC cis rs13242816 1.000 rs34082946 chr7:116154313 G/A cg04696780 chr7:116139425 CAV2 -0.61 -5.55 -0.32 7.01e-8 P wave duration; CESC cis rs17253792 0.915 rs79100824 chr14:56179606 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.74 5.1 0.3 6.53e-7 Putamen volume; CESC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg04166393 chr7:2884313 GNA12 0.62 7.7 0.43 2.71e-13 Height; CESC cis rs2066819 1.000 rs59626664 chr12:56636975 C/G cg26734620 chr12:56694298 CS 1.04 6.73 0.38 1.06e-10 Psoriasis vulgaris; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23837683 chr19:3959058 DAPK3 -0.63 -7.44 -0.42 1.4e-12 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs10465746 0.780 rs1324486 chr1:84384825 A/G cg10977910 chr1:84465055 TTLL7 -0.51 -6.89 -0.39 4.15e-11 Obesity-related traits; CESC cis rs4409675 0.576 rs2078328 chr1:28224976 A/G cg23691781 chr1:28212827 C1orf38 0.28 5.67 0.33 3.72e-8 Corneal astigmatism; CESC cis rs10754283 0.967 rs6657988 chr1:90106745 G/C cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg23978390 chr7:1156363 C7orf50 0.68 7.25 0.41 4.72e-12 Bronchopulmonary dysplasia; CESC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg26335602 chr6:28129616 ZNF389 -0.47 -6.54 -0.37 3.23e-10 Depression; CESC cis rs13095912 1.000 rs13100034 chr3:185318804 G/A cg11274856 chr3:185301563 NA 0.37 6.02 0.35 5.74e-9 Systolic blood pressure; CESC trans rs7246760 1.000 rs68176351 chr19:9864222 G/A cg02900749 chr2:68251473 NA -0.79 -6.66 -0.38 1.57e-10 Pursuit maintenance gain; CESC cis rs3126085 0.935 rs1496051 chr1:152164923 G/A cg03465714 chr1:152285911 FLG -0.45 -5.53 -0.32 7.86e-8 Atopic dermatitis; CESC cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg02297831 chr4:17616191 MED28 -0.51 -6.45 -0.37 5.43e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2070488 0.775 rs4407366 chr3:38521425 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.78 12.05 0.59 6.07e-27 Electrocardiographic conduction measures; CESC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg23048001 chr7:2026167 MAD1L1 0.46 6.24 0.36 1.75e-9 Schizophrenia; CESC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg06873352 chr17:61820015 STRADA 0.48 7.0 0.4 2.07e-11 Height; CESC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg19717773 chr7:2847554 GNA12 -0.46 -6.45 -0.37 5.34e-10 Height; CESC cis rs3096299 0.967 rs2911253 chr16:89488587 T/G cg16743903 chr16:89593216 SPG7 -0.44 -5.74 -0.33 2.54e-8 Multiple myeloma (IgH translocation); CESC trans rs61931739 1.000 rs12424741 chr12:34022771 C/T cg26384229 chr12:38710491 ALG10B -0.45 -6.21 -0.36 1.98e-9 Morning vs. evening chronotype; CESC cis rs2882667 0.824 rs12173085 chr5:138480025 A/G cg04439458 chr5:138467593 SIL1 -0.38 -5.75 -0.33 2.5e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg25934064 chr3:52569026 NT5DC2 0.27 5.48 0.32 9.91e-8 Electroencephalogram traits; CESC cis rs2404602 0.735 rs4886493 chr15:76679026 A/G cg23625390 chr15:77176239 SCAPER -0.44 -6.02 -0.35 5.72e-9 Blood metabolite levels; CESC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg13628971 chr7:2884303 GNA12 0.63 8.11 0.45 1.95e-14 Height; CESC cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.26 0.31 2.99e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05896563 chr6:7390048 CAGE1;RIOK1 0.56 6.46 0.37 4.94e-10 Gut microbiome composition (summer); CESC cis rs1577917 1.000 rs12154056 chr6:86634094 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.33 2.14e-8 Response to antipsychotic treatment; CESC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg23283495 chr1:209979779 IRF6 0.32 5.1 0.3 6.59e-7 Monobrow; CESC cis rs7772486 0.790 rs6570724 chr6:146151283 T/C cg23711669 chr6:146136114 FBXO30 0.9 13.27 0.63 3.71e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs9747201 0.832 rs4072580 chr17:80160337 A/C cg09264619 chr17:80180166 NA -0.44 -5.22 -0.31 3.67e-7 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs8067545 0.611 rs1859407 chr17:20078137 T/C cg13482628 chr17:19912719 NA -0.44 -5.83 -0.34 1.58e-8 Schizophrenia; CESC cis rs12995491 0.933 rs7590305 chr2:88513131 C/T cg14558114 chr2:88469736 THNSL2 -0.5 -6.99 -0.39 2.24e-11 Response to metformin (IC50); CESC cis rs6973256 0.569 rs12532950 chr7:133434286 C/T cg10665199 chr7:133106180 EXOC4 0.41 5.71 0.33 3.07e-8 Intelligence (multi-trait analysis); CESC cis rs763121 0.853 rs5995610 chr22:39064681 C/T cg06022373 chr22:39101656 GTPBP1 0.88 13.95 0.65 1.51e-33 Menopause (age at onset); CESC cis rs11871801 0.517 rs646123 chr17:40720632 G/A cg16308533 chr17:40838983 CNTNAP1 0.4 5.17 0.3 4.61e-7 Crohn's disease; CESC cis rs6540556 0.723 rs9430016 chr1:209916884 A/G cg23920097 chr1:209922102 NA -0.4 -5.88 -0.34 1.22e-8 Red blood cell count; CESC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg02951883 chr7:2050386 MAD1L1 -0.48 -6.4 -0.37 6.92e-10 Bipolar disorder and schizophrenia; CESC cis rs3125734 0.633 rs10821968 chr10:63993905 C/T cg09941381 chr10:64027924 RTKN2 0.31 5.2 0.3 3.92e-7 Rheumatoid arthritis; CESC cis rs4460629 0.742 rs11581730 chr1:155082158 A/T cg01019262 chr1:155095195 NA -0.3 -5.09 -0.3 6.75e-7 Serum magnesium levels; CESC cis rs3096299 0.874 rs3102342 chr16:89451575 T/C cg00750074 chr16:89608354 SPG7 -0.39 -5.51 -0.32 8.38e-8 Multiple myeloma (IgH translocation); CESC cis rs367615 0.704 rs55956735 chr5:108845042 A/G cg17395555 chr5:108820864 NA 0.63 11.15 0.57 6.1e-24 Colorectal cancer (SNP x SNP interaction); CESC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg04944784 chr2:26401820 FAM59B -0.66 -7.53 -0.42 7.95e-13 Gut microbiome composition (summer); CESC cis rs9513627 0.573 rs4771336 chr13:100210610 T/G cg25919922 chr13:100150906 NA 0.71 8.22 0.45 8.86e-15 Obesity-related traits; CESC cis rs9916302 0.821 rs12938268 chr17:37572139 G/A cg00129232 chr17:37814104 STARD3 -0.53 -6.59 -0.38 2.35e-10 Glomerular filtration rate (creatinine); CESC cis rs921968 0.565 rs6745700 chr2:219639862 T/C cg02176678 chr2:219576539 TTLL4 -0.43 -7.66 -0.43 3.42e-13 Mean corpuscular hemoglobin concentration; CESC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg21782813 chr7:2030301 MAD1L1 0.5 7.26 0.41 4.36e-12 Bipolar disorder and schizophrenia; CESC cis rs3741798 1.000 rs3825259 chr12:12496635 A/G cg08615371 chr12:12503544 MANSC1 0.74 5.36 0.31 1.82e-7 Cerebrospinal fluid biomarker levels; CESC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.48 -0.32 1.01e-7 Developmental language disorder (linguistic errors); CESC cis rs3617 0.625 rs6769789 chr3:52874446 C/T cg07507251 chr3:52567010 NT5DC2 -0.32 -5.41 -0.32 1.4e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs28493229 0.522 rs2287692 chr19:41289756 G/A cg21869046 chr19:41225005 ITPKC 0.53 6.45 0.37 5.29e-10 Kawasaki disease; CESC cis rs6815814 0.950 rs5743571 chr4:38805489 C/T cg02016764 chr4:38805732 TLR1 -0.62 -7.23 -0.41 5.15e-12 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26406407 chr10:438229 DIP2C 0.44 6.06 0.35 4.7e-9 Fibrinogen levels; CESC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg24675658 chr1:53192096 ZYG11B 0.63 8.81 0.48 1.7e-16 Monocyte count; CESC cis rs7267979 0.966 rs6083817 chr20:25343998 G/C cg08601574 chr20:25228251 PYGB -0.38 -5.46 -0.32 1.12e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08810106 chr16:18936940 SMG1 -0.43 -6.0 -0.35 6.31e-9 Gambling; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg26215009 chr5:34008104 AMACR 0.46 6.07 0.35 4.5e-9 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs35160687 0.644 rs11127024 chr2:86505453 C/T cg01119172 chr2:86362222 SNORD94;PTCD3 -0.4 -5.39 -0.31 1.59e-7 Night sleep phenotypes; CESC cis rs9303280 0.806 rs10445308 chr17:37938047 C/T cg20243544 chr17:37824526 PNMT 0.52 7.01 0.4 1.99e-11 Self-reported allergy; CESC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.94 0.34 8.83e-9 Tonsillectomy; CESC cis rs72781680 0.716 rs6731314 chr2:24048338 C/T cg08917208 chr2:24149416 ATAD2B -0.65 -6.38 -0.36 7.81e-10 Lymphocyte counts; CESC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg16145915 chr7:1198662 ZFAND2A -0.48 -7.02 -0.4 1.8e-11 Longevity;Endometriosis; CESC cis rs7666738 0.791 rs1426661 chr4:98874303 C/G cg05340658 chr4:99064831 C4orf37 0.75 11.1 0.56 9.43e-24 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04228104 chr1:150551925 MCL1 0.59 6.42 0.37 6.25e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04456437 chr3:119217424 C3orf1 0.54 6.01 0.35 6.06e-9 Gut microbiome composition (summer); CESC cis rs3741151 0.773 rs57673166 chr11:73232557 T/A cg17517138 chr11:73019481 ARHGEF17 1.05 7.72 0.43 2.46e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg03609598 chr5:56110824 MAP3K1 -0.5 -5.29 -0.31 2.51e-7 Initial pursuit acceleration; CESC cis rs3749237 0.964 rs2234385 chr3:49846041 G/A cg03060546 chr3:49711283 APEH 0.65 7.65 0.43 3.69e-13 Resting heart rate; CESC cis rs2294693 0.945 rs9369252 chr6:40986028 C/T cg14769373 chr6:40998127 UNC5CL 0.49 6.37 0.36 8.54e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs1461503 0.934 rs7107560 chr11:122845380 T/C cg27398637 chr11:122830231 C11orf63 -0.55 -8.03 -0.44 3.2e-14 Menarche (age at onset); CESC cis rs13040088 1.000 rs12480870 chr20:61543606 A/C cg23096297 chr20:61557774 DIDO1 0.97 10.83 0.55 7.35e-23 Menopause (age at onset); CESC cis rs4948102 0.924 rs13241866 chr7:56090878 C/G cg09872392 chr7:56161020 PHKG1 -0.4 -6.28 -0.36 1.4e-9 Plasma homocysteine levels (post-methionine load test); CESC cis rs1046896 0.512 rs3785513 chr17:80886748 G/A cg19046167 chr17:80928561 B3GNTL1 0.46 6.11 0.35 3.62e-9 Glycated hemoglobin levels; CESC cis rs4472734 0.796 rs12757404 chr1:214629616 A/G cg00063699 chr1:214624242 PTPN14 -0.33 -5.08 -0.3 7.25e-7 Height; CESC cis rs56399783 0.614 rs11765492 chr7:2771642 G/A cg19731401 chr7:2775893 GNA12 0.69 6.06 0.35 4.74e-9 Childhood ear infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01304440 chr3:32726769 CNOT10 -0.57 -6.23 -0.36 1.8e-9 Gut microbiome composition (summer); CESC cis rs5753618 0.583 rs5753628 chr22:31860322 A/G cg00478049 chr22:31556069 RNF185 -0.43 -5.15 -0.3 5.09e-7 Colorectal cancer; CESC cis rs6088590 0.813 rs1884668 chr20:33285514 A/G cg24642439 chr20:33292090 TP53INP2 0.68 9.04 0.49 3.51e-17 Coronary artery disease; CESC cis rs6964587 0.839 rs10808086 chr7:91447515 T/C cg17063962 chr7:91808500 NA 0.51 6.45 0.37 5.2e-10 Breast cancer; CESC cis rs12765878 0.967 rs34887477 chr10:105643436 C/T cg11005552 chr10:105648138 OBFC1 0.35 5.1 0.3 6.34e-7 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05935374 chr11:82782929 RAB30 0.47 6.28 0.36 1.36e-9 Gut microbiota (bacterial taxa); CESC cis rs7208859 0.614 rs73265646 chr17:29244023 C/T cg19761014 chr17:28927070 LRRC37B2 0.71 5.56 0.32 6.59e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10861342 1.000 rs11112390 chr12:105542200 A/C cg23923672 chr12:105501055 KIAA1033 0.7 5.94 0.34 9.01e-9 IgG glycosylation; CESC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg19163074 chr7:65112434 INTS4L2 0.43 5.57 0.32 6.21e-8 Aortic root size; CESC cis rs12477438 0.501 rs13008171 chr2:99743419 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.63 0.61 6.22e-29 Chronic sinus infection; CESC trans rs1505368 0.836 rs10201067 chr2:213284411 A/G cg00572323 chr16:29706151 QPRT 0.37 6.17 0.35 2.61e-9 Symmetrical dimethylarginine levels; CESC cis rs2635047 0.967 rs2576056 chr18:44675462 G/C cg19077165 chr18:44547161 KATNAL2 -0.43 -5.73 -0.33 2.73e-8 Educational attainment; CESC cis rs8017423 0.967 rs11159958 chr14:90716051 T/C cg14092571 chr14:90743983 NA -0.58 -8.84 -0.48 1.41e-16 Mortality in heart failure; CESC cis rs11098499 0.865 rs3956464 chr4:120256764 T/C cg09307838 chr4:120376055 NA 0.81 10.94 0.56 3.14e-23 Corneal astigmatism; CESC trans rs2727020 0.637 rs1164673 chr11:49328356 C/G cg15704280 chr7:45808275 SEPT13 0.69 9.34 0.5 4.03e-18 Coronary artery disease; CESC cis rs6690583 0.623 rs12033900 chr1:85478559 T/C cg22488158 chr1:85528044 WDR63 0.55 5.16 0.3 4.76e-7 Serum sulfate level; CESC cis rs8077577 0.671 rs12450760 chr17:18253822 C/T cg16794390 chr17:18148240 FLII 0.38 6.25 0.36 1.59e-9 Obesity-related traits; CESC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC trans rs35110281 0.720 rs162392 chr21:44941406 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 7.29 0.41 3.65e-12 Mean corpuscular volume; CESC cis rs11122272 0.735 rs2256908 chr1:231506557 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.68 -0.43 3.02e-13 Hemoglobin concentration; CESC cis rs9486715 1.000 rs6905568 chr6:97066382 T/C cg06623918 chr6:96969491 KIAA0776 -0.86 -12.58 -0.61 9.16e-29 Headache; CESC cis rs2933343 0.700 rs1680788 chr3:128625318 C/T cg11901034 chr3:128598214 ACAD9 -0.39 -5.71 -0.33 3.1e-8 IgG glycosylation; CESC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg21770322 chr7:97807741 LMTK2 0.55 8.41 0.46 2.49e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg02487422 chr3:49467188 NICN1 0.39 5.09 0.3 6.86e-7 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02322435 chr11:67815326 TCIRG1 -0.59 -6.57 -0.37 2.66e-10 Gut microbiome composition (summer); CESC cis rs8067354 0.958 rs2333563 chr17:57839568 A/G cg02344993 chr17:57696989 CLTC 0.48 6.29 0.36 1.29e-9 Hemoglobin concentration; CESC cis rs763121 0.785 rs6001203 chr22:39099602 T/C cg06544989 chr22:39130855 UNC84B 0.52 9.88 0.52 8.35e-20 Menopause (age at onset); CESC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg00129232 chr17:37814104 STARD3 -0.54 -7.05 -0.4 1.59e-11 Glomerular filtration rate (creatinine); CESC cis rs926392 0.666 rs35166252 chr20:37695601 C/T cg16355469 chr20:37678765 NA 0.53 5.86 0.34 1.36e-8 Dialysis-related mortality; CESC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg12667521 chr19:29218732 NA 0.42 6.35 0.36 9.3e-10 Methadone dose in opioid dependence; CESC cis rs72781680 0.898 rs72796158 chr2:23935727 T/C cg08917208 chr2:24149416 ATAD2B 1.1 10.15 0.53 1.18e-20 Lymphocyte counts; CESC cis rs9325144 0.560 rs10506125 chr12:39120287 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.61 0.42 4.94e-13 Morning vs. evening chronotype; CESC cis rs7539624 0.947 rs6683379 chr1:223906421 A/G cg10100437 chr1:223903862 CAPN2 -0.35 -5.24 -0.31 3.28e-7 Schizophrenia; CESC cis rs4253772 0.637 rs6008357 chr22:46652104 T/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.48 5.11 0.3 6.16e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2249625 0.874 rs7451395 chr6:72924499 G/A cg18830697 chr6:72922368 RIMS1 -0.41 -5.73 -0.33 2.79e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg07701084 chr6:150067640 NUP43 0.44 5.93 0.34 9.65e-9 Lung cancer; CESC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg23161317 chr6:28129485 ZNF389 0.47 5.89 0.34 1.18e-8 Depression; CESC cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg04166393 chr7:2884313 GNA12 -0.6 -7.35 -0.41 2.4e-12 Height; CESC cis rs9911578 0.935 rs7216698 chr17:57007495 G/A cg12560992 chr17:57184187 TRIM37 0.8 12.47 0.61 2.22e-28 Intelligence (multi-trait analysis); CESC cis rs1707322 0.752 rs12062535 chr1:46222880 G/A cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs853679 0.607 rs71559070 chr6:28038929 G/A cg18032046 chr6:28092343 ZSCAN16 -0.82 -5.06 -0.3 7.83e-7 Depression; CESC cis rs2066819 1.000 rs17118439 chr12:56667604 C/T cg26714650 chr12:56694279 CS 1.34 9.29 0.5 6.05e-18 Psoriasis vulgaris; CESC cis rs9486719 1.000 rs2205755 chr6:96864704 A/G cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg27129171 chr3:47204927 SETD2 0.69 10.19 0.53 8.8e-21 Colorectal cancer; CESC cis rs9583531 0.600 rs1441042 chr13:111365589 T/G cg15841412 chr13:111365552 ING1 0.49 6.16 0.35 2.71e-9 Coronary artery disease; CESC cis rs656900 0.874 rs685487 chr15:80136129 A/G cg02196730 chr15:80188777 MTHFS -0.42 -5.37 -0.31 1.7e-7 Cerebrospinal P-tau181p levels; CESC cis rs4711336 1.000 rs3818523 chr6:33660371 G/A cg14003231 chr6:33640908 ITPR3 0.32 5.42 0.32 1.34e-7 Height; CESC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg14703610 chr5:56206110 C5orf35 0.52 6.91 0.39 3.62e-11 Breast cancer;Breast cancer (early onset); CESC cis rs826838 1.000 rs826889 chr12:39101076 G/A cg13010199 chr12:38710504 ALG10B -0.42 -5.86 -0.34 1.37e-8 Heart rate; CESC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg22143856 chr6:28129313 ZNF389 0.51 6.62 0.38 2e-10 Parkinson's disease; CESC trans rs801193 0.839 rs12534943 chr7:66070520 A/G cg26939375 chr7:64535504 NA -0.54 -7.43 -0.42 1.54e-12 Aortic root size; CESC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -5.7 -0.33 3.12e-8 Extrinsic epigenetic age acceleration; CESC cis rs660899 0.595 rs11577684 chr1:44254280 C/G cg11704212 chr1:44303111 ST3GAL3 -0.38 -5.12 -0.3 5.99e-7 Hypertension risk in short sleep duration; CESC cis rs6484504 0.576 rs158136 chr11:31220712 C/T cg14844989 chr11:31128820 NA -0.42 -5.96 -0.34 7.83e-9 Red blood cell count; CESC cis rs262150 0.567 rs2040897 chr7:158803848 C/T cg19418458 chr7:158789849 NA -0.38 -5.78 -0.33 2.11e-8 Facial morphology (factor 20); CESC cis rs11626933 0.959 rs8005973 chr14:90774951 C/T cg14092571 chr14:90743983 NA -0.92 -15.34 -0.69 1.96e-38 Gut microbiota (bacterial taxa); CESC cis rs3820928 1.000 rs4675116 chr2:227769607 A/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.79 -0.34 1.97e-8 Pulmonary function; CESC cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 6.08 0.35 4.17e-9 Colorectal cancer; CESC cis rs2688608 0.592 rs7080579 chr10:75504029 T/A cg23231163 chr10:75533350 FUT11 -0.35 -5.4 -0.32 1.45e-7 Inflammatory bowel disease; CESC cis rs7481584 0.624 rs412149 chr11:3069943 G/A cg25174290 chr11:3078921 CARS -0.52 -7.31 -0.41 3.09e-12 Calcium levels; CESC cis rs1215050 0.791 rs1215054 chr4:98863009 T/G cg05340658 chr4:99064831 C4orf37 -0.5 -6.65 -0.38 1.66e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4268898 0.679 rs2551181 chr2:24437548 C/T cg20701182 chr2:24300061 SF3B14 -0.55 -6.15 -0.35 2.89e-9 Asthma; CESC cis rs6831352 0.918 rs13107558 chr4:100050200 C/A cg12011299 chr4:100065546 ADH4 -0.55 -6.28 -0.36 1.38e-9 Alcohol dependence; CESC cis rs10197940 0.662 rs4592848 chr2:152337822 G/A cg06191203 chr2:152266755 RIF1 -0.45 -5.29 -0.31 2.59e-7 Lung cancer; CESC cis rs12451471 0.559 rs1042396 chr17:78084769 G/A cg24585782 chr17:78113791 EIF4A3 -0.58 -7.63 -0.42 4.35e-13 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs3733585 0.699 rs6856127 chr4:9965443 T/C cg02734326 chr4:10020555 SLC2A9 -0.43 -6.03 -0.35 5.47e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs477692 0.655 rs7906680 chr10:131442671 C/G cg05714579 chr10:131428358 MGMT -0.59 -8.48 -0.46 1.61e-15 Response to temozolomide; CESC trans rs4534636 0.812 rs11045985 chr12:8666378 A/C cg14536431 chr21:40030097 ERG -0.41 -6.08 -0.35 4.11e-9 Response to radiotherapy in prostate cancer (toxicity, urinary frequency); CESC cis rs1949733 0.656 rs6845969 chr4:8402465 A/T cg11789530 chr4:8429930 ACOX3 0.69 9.88 0.52 8.38e-20 Response to antineoplastic agents; CESC cis rs7191700 0.511 rs8043625 chr16:11361895 C/G cg00044050 chr16:11439710 C16orf75 -0.44 -5.38 -0.31 1.62e-7 Multiple sclerosis; CESC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg21238619 chr17:78079768 GAA 0.4 5.85 0.34 1.42e-8 Yeast infection; CESC cis rs4523957 0.690 rs11867782 chr17:2090507 T/G cg16513277 chr17:2031491 SMG6 -0.72 -10.08 -0.53 1.92e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2637266 0.935 rs1907300 chr10:78325091 A/G cg18941641 chr10:78392320 NA 0.38 6.83 0.39 5.66e-11 Pulmonary function; CESC trans rs747782 0.528 rs16905753 chr11:48285906 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.46 0.37 4.95e-10 Intraocular pressure; CESC cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.63 0.61 6.21e-29 Personality dimensions; CESC cis rs9359856 0.517 rs17506515 chr6:90507332 G/A cg13799429 chr6:90582589 CASP8AP2 -0.66 -6.74 -0.38 9.61e-11 Bipolar disorder; CESC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg09699651 chr6:150184138 LRP11 0.4 5.1 0.3 6.34e-7 Lung cancer; CESC cis rs926938 0.618 rs1286560 chr1:115375930 C/T cg12756093 chr1:115239321 AMPD1 -0.45 -6.15 -0.35 2.9e-9 Autism; CESC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg27170947 chr2:26402098 FAM59B -0.71 -8.2 -0.45 1.02e-14 Gut microbiome composition (summer); CESC cis rs2637266 0.783 rs12258504 chr10:78477055 C/T cg18941641 chr10:78392320 NA 0.4 7.59 0.42 5.51e-13 Pulmonary function; CESC cis rs1062177 0.756 rs2915827 chr5:151119705 T/A cg00977110 chr5:151150581 G3BP1 -0.62 -6.47 -0.37 4.72e-10 Preschool internalizing problems; CESC cis rs965469 0.895 rs6139124 chr20:3398144 C/T cg25506879 chr20:3388711 C20orf194 -0.63 -6.59 -0.38 2.3e-10 IFN-related cytopenia; CESC cis rs7267979 0.873 rs6115093 chr20:25210730 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 14.59 0.67 8.75e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs9443189 0.570 rs569731 chr6:76357593 G/A cg01950844 chr6:76311363 SENP6 0.87 9.27 0.49 6.59e-18 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11017490 chr15:79044350 NA -0.49 -6.93 -0.39 3.21e-11 Gut microbiome composition (summer); CESC cis rs16917546 1.000 rs10995251 chr10:64398466 C/T cg03961010 chr10:64397487 ZNF365 -0.38 -6.11 -0.35 3.58e-9 Basal cell carcinoma; CESC cis rs1008375 1.000 rs4698200 chr4:17657051 G/A cg15017067 chr4:17643749 FAM184B 0.37 5.23 0.31 3.39e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7429990 0.965 rs7649981 chr3:47999337 T/A cg11946769 chr3:48343235 NME6 0.44 5.38 0.31 1.61e-7 Educational attainment (years of education); CESC cis rs2806561 0.704 rs1757039 chr1:23508657 A/G cg12483005 chr1:23474871 LUZP1 0.39 6.06 0.35 4.58e-9 Height; CESC cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg25517755 chr10:38738941 LOC399744 -0.47 -6.05 -0.35 4.86e-9 Extrinsic epigenetic age acceleration; CESC cis rs2997447 0.601 rs61776577 chr1:26431931 T/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs6674176 0.660 rs6801 chr1:44396646 C/G cg12908607 chr1:44402522 ARTN 0.53 7.92 0.44 6.48e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs10089 1.000 rs1962291 chr5:127445373 A/G cg19767477 chr5:127420684 SLC12A2 0.41 5.57 0.32 6.15e-8 Ileal carcinoids; CESC trans rs9951602 0.512 rs9958376 chr18:76655167 G/T cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg00339695 chr16:24857497 SLC5A11 0.49 6.29 0.36 1.33e-9 Intelligence (multi-trait analysis); CESC cis rs7208859 0.673 rs216410 chr17:28903831 C/G cg04154034 chr17:28927549 LRRC37B2 -0.57 -5.63 -0.33 4.65e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11064206 chr12:123459532 OGFOD2;ABCB9 0.45 6.03 0.35 5.43e-9 Systemic lupus erythematosus; CESC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg12463550 chr7:65579703 CRCP -0.57 -7.29 -0.41 3.57e-12 Aortic root size; CESC cis rs68170813 0.559 rs80307895 chr7:106907781 T/A cg02696742 chr7:106810147 HBP1 -0.52 -5.09 -0.3 6.84e-7 Coronary artery disease; CESC cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg02487422 chr3:49467188 NICN1 0.4 5.11 0.3 6.09e-7 Parkinson's disease; CESC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.26 0.41 4.27e-12 Height; CESC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg11663144 chr21:46675770 NA -0.47 -6.99 -0.39 2.27e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.02 0.35 5.67e-9 Bipolar disorder; CESC cis rs12410462 0.579 rs115037090 chr1:227666191 A/G cg04117972 chr1:227635322 NA 0.8 6.85 0.39 5.16e-11 Major depressive disorder; CESC trans rs13169113 0.782 rs7447513 chr5:125348925 G/A cg26424645 chr1:227729598 NA -0.39 -6.25 -0.36 1.63e-9 Cognitive performance; CESC cis rs7772486 0.754 rs6570703 chr6:145957052 C/T cg05347473 chr6:146136440 FBXO30 0.53 6.96 0.39 2.72e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.04 -0.56 1.41e-23 Alzheimer's disease; CESC cis rs6582630 0.537 rs3942440 chr12:38459672 A/G cg26384229 chr12:38710491 ALG10B 0.71 10.82 0.55 7.82e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs9303401 0.614 rs34058624 chr17:57118121 T/C cg12560992 chr17:57184187 TRIM37 0.5 5.2 0.3 3.94e-7 Cognitive test performance; CESC cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.75 -9.25 -0.49 7.57e-18 Body mass index (adult); CESC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.49 -5.33 -0.31 2.06e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4076764 1.000 rs7528020 chr1:163426537 G/A cg06092702 chr1:163392909 NA -0.37 -5.38 -0.31 1.65e-7 Motion sickness; CESC cis rs2732480 0.500 rs7315820 chr12:48598938 C/T cg04545296 chr12:48745243 ZNF641 0.4 6.74 0.38 9.66e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg11168104 chr5:1857477 NA -0.36 -5.28 -0.31 2.76e-7 Cardiovascular disease risk factors; CESC cis rs2650000 0.798 rs2701175 chr12:121391671 C/A cg02403541 chr12:121454288 C12orf43 -0.53 -6.88 -0.39 4.43e-11 Metabolic traits;LDL cholesterol; CESC cis rs9309473 0.898 rs6546851 chr2:73833283 C/T cg20560298 chr2:73613845 ALMS1 -0.45 -6.07 -0.35 4.36e-9 Metabolite levels; CESC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9354352 0.784 rs2062327 chr6:66689923 C/G cg07460842 chr6:66804631 NA -0.71 -10.34 -0.54 2.78e-21 Initial pursuit acceleration in psychotic disorders; CESC cis rs7267979 0.966 rs2227890 chr20:25260931 A/G cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1728785 1.000 rs1645981 chr16:68571648 T/C cg02972257 chr16:68554789 NA -0.55 -6.34 -0.36 9.7e-10 Ulcerative colitis; CESC cis rs6424115 0.800 rs2229581 chr1:24201094 G/C cg10978503 chr1:24200527 CNR2 0.33 6.64 0.38 1.73e-10 Immature fraction of reticulocytes; CESC cis rs8072100 0.512 rs9674670 chr17:45386157 G/A cg08085267 chr17:45401833 C17orf57 -0.55 -7.27 -0.41 4.17e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26289012 chr17:3540036 CTNS;SHPK -0.48 -6.3 -0.36 1.26e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg22974920 chr21:40686053 BRWD1 -0.42 -5.19 -0.3 4.1e-7 Cognitive function; CESC cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg06808227 chr14:105710500 BRF1 -0.6 -7.17 -0.4 7.32e-12 Mean platelet volume;Platelet distribution width; CESC cis rs35520189 0.845 rs34899562 chr2:113641472 C/T cg06156847 chr2:113672199 IL1F7 0.36 5.47 0.32 1.04e-7 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs959260 1.000 rs2385264 chr17:73364992 C/T cg20590849 chr17:73267439 MIF4GD -0.55 -6.4 -0.37 6.95e-10 Systemic lupus erythematosus; CESC cis rs2072732 0.861 rs56176404 chr1:2940998 A/G cg15211996 chr1:2936768 ACTRT2 0.34 5.23 0.31 3.5e-7 Plateletcrit; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07522190 chr16:28925877 RABEP2 0.43 6.11 0.35 3.5e-9 Fibrinogen levels; CESC cis rs3806843 1.000 rs11167600 chr5:140174865 G/C cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.12 -0.3 5.99e-7 Depressive symptoms (multi-trait analysis); CESC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs9399135 0.967 rs9321481 chr6:135352648 C/G cg22676075 chr6:135203613 NA -0.49 -6.62 -0.38 2.02e-10 Red blood cell count; CESC cis rs9399401 0.710 rs12197866 chr6:142706063 C/T cg03128060 chr6:142623767 GPR126 0.37 6.08 0.35 4.08e-9 Chronic obstructive pulmonary disease; CESC cis rs7771547 0.573 rs9470274 chr6:36397229 G/A cg07856975 chr6:36356162 ETV7 0.36 5.38 0.31 1.67e-7 Platelet distribution width; CESC cis rs9488822 0.676 rs6918059 chr6:116349041 C/T cg05304507 chr6:116381966 FRK 0.26 6.74 0.38 9.69e-11 Cholesterol, total;LDL cholesterol; CESC cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.08e-7 Colonoscopy-negative controls vs population controls; CESC cis rs977987 0.806 rs4638613 chr16:75425553 C/T cg03315344 chr16:75512273 CHST6 0.42 6.05 0.35 4.89e-9 Dupuytren's disease; CESC cis rs796364 0.951 rs12463436 chr2:201061962 C/G cg23649088 chr2:200775458 C2orf69 0.53 5.65 0.33 4.23e-8 Schizophrenia; CESC cis rs4728302 0.869 rs13233715 chr7:133617471 C/T cg10665199 chr7:133106180 EXOC4 0.39 5.3 0.31 2.49e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7914558 1.000 rs4917380 chr10:104775335 C/G cg15744005 chr10:104629667 AS3MT -0.33 -5.38 -0.31 1.63e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2880765 0.835 rs1872074 chr15:86033184 T/G cg19183879 chr15:85880815 NA -0.25 -5.18 -0.3 4.49e-7 Coronary artery disease; CESC cis rs10242455 0.557 rs59672032 chr7:99058697 T/C cg13560068 chr7:99070416 ZNF789 0.67 5.15 0.3 5.11e-7 Blood metabolite levels; CESC cis rs3087591 0.920 rs4795592 chr17:29612620 C/G cg24425628 chr17:29625626 OMG;NF1 -0.45 -5.63 -0.33 4.5e-8 Hip circumference; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09676606 chr12:102132872 SYCP3 0.48 6.26 0.36 1.5e-9 Fibrinogen levels; CESC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg00166722 chr3:10149974 C3orf24 0.49 6.32 0.36 1.13e-9 Alzheimer's disease; CESC cis rs265548 0.646 rs36692 chr19:17906839 C/T cg21960279 chr19:17905606 B3GNT3 0.47 7.1 0.4 1.18e-11 Tumor biomarkers; CESC cis rs9287719 0.935 rs1309 chr2:10743546 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs9487051 0.714 rs6930733 chr6:109631587 T/C cg01475377 chr6:109611718 NA -0.46 -7.2 -0.4 6.15e-12 Reticulocyte fraction of red cells; CESC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg08392591 chr16:89556376 ANKRD11 0.6 8.25 0.45 7.33e-15 Multiple myeloma (IgH translocation); CESC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.01 0.4 1.92e-11 Bipolar disorder; CESC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC trans rs7980799 0.682 rs1351682 chr12:33598775 G/A cg26384229 chr12:38710491 ALG10B -0.54 -7.68 -0.43 3.1400000000000003e-13 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs35110281 0.807 rs28840140 chr21:45039163 T/C cg04455712 chr21:45112962 RRP1B 0.42 6.33 0.36 1.02e-9 Mean corpuscular volume; CESC cis rs6061231 0.544 rs2427314 chr20:60973666 C/T cg24112000 chr20:60950667 NA -0.52 -7.56 -0.42 6.63e-13 Colorectal cancer; CESC cis rs1355223 0.902 rs6484726 chr11:34697558 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.24 -0.36 1.7e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs9303280 0.776 rs9891174 chr17:38031802 T/A cg20243544 chr17:37824526 PNMT 0.5 6.51 0.37 3.84e-10 Self-reported allergy; CESC cis rs116095464 0.558 rs7713524 chr5:276200 C/T cg10591111 chr5:226296 SDHA 0.49 5.99 0.35 6.77e-9 Breast cancer; CESC cis rs9905704 0.647 rs11652713 chr17:57079742 C/T cg12560992 chr17:57184187 TRIM37 0.64 7.98 0.44 4.3e-14 Testicular germ cell tumor; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11321298 chr22:40766510 SGSM3 0.44 6.02 0.35 5.7e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4720575 1.000 rs4720575 chr7:47086805 A/G cg00036614 chr7:47093842 NA -0.43 -6.57 -0.37 2.59e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs9291683 0.595 rs13145442 chr4:10037261 C/A cg00071950 chr4:10020882 SLC2A9 0.87 15.5 0.69 5.26e-39 Bone mineral density; CESC cis rs919433 0.927 rs1429412 chr2:198190894 A/G cg20885578 chr2:198174922 NA -0.39 -5.09 -0.3 6.83e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs6446731 0.517 rs2071671 chr4:3269787 C/G cg08886695 chr4:3369023 RGS12 0.39 5.67 0.33 3.67e-8 Mean platelet volume; CESC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg22029157 chr1:209979665 IRF6 0.76 8.93 0.48 7.36e-17 Cleft lip with or without cleft palate; CESC cis rs1559088 0.842 rs12977993 chr19:33580453 T/A cg17764715 chr19:33622953 WDR88 0.52 6.87 0.39 4.56e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs6570726 0.791 rs9373464 chr6:145907167 T/C cg23711669 chr6:146136114 FBXO30 0.91 13.64 0.64 1.96e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs6964587 1.000 rs2237568 chr7:91622676 G/A cg17063962 chr7:91808500 NA 0.57 7.82 0.43 1.22e-13 Breast cancer; CESC cis rs11098499 0.866 rs13125526 chr4:120288019 G/A cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs9611565 0.765 rs202659 chr22:41811620 T/C cg06481639 chr22:41940642 POLR3H 0.62 6.52 0.37 3.49e-10 Vitiligo; CESC cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg09658497 chr7:2847517 GNA12 -0.34 -5.09 -0.3 6.75e-7 Height; CESC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.37 -0.54 2.25e-21 Alzheimer's disease; CESC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.65 7.42 0.41 1.57e-12 Gut microbiome composition (summer); CESC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg05564831 chr3:52568323 NT5DC2 0.45 6.96 0.39 2.68e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01143375 chr3:191670642 NA -0.56 -6.28 -0.36 1.35e-9 Gut microbiome composition (summer); CESC cis rs116095464 0.542 rs28650039 chr5:273954 C/A cg22857025 chr5:266934 NA -1.3 -18.68 -0.75 2.81e-50 Breast cancer; CESC cis rs6580649 0.941 rs57054831 chr12:48486892 C/T cg05342945 chr12:48394962 COL2A1 0.5 5.74 0.33 2.59e-8 Lung cancer; CESC cis rs3087591 0.922 rs2905799 chr17:29536901 G/A cg24425628 chr17:29625626 OMG;NF1 0.44 5.53 0.32 7.56e-8 Hip circumference; CESC cis rs9908102 0.740 rs8071615 chr17:12914535 G/T cg26162695 chr17:12921313 ELAC2 0.49 5.18 0.3 4.41e-7 Schizophrenia; CESC cis rs6963495 0.674 rs75880756 chr7:105163821 G/C cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC trans rs11165623 0.792 rs9437609 chr1:96977961 A/C cg10631902 chr5:14652156 NA -0.49 -7.3 -0.41 3.42e-12 Hip circumference;Waist circumference; CESC cis rs78456975 0.550 rs11904276 chr2:1524006 T/C cg26248373 chr2:1572462 NA -0.56 -6.49 -0.37 4.15e-10 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7772486 0.713 rs2328704 chr6:146020494 T/C cg05347473 chr6:146136440 FBXO30 -0.48 -6.34 -0.36 1.01e-9 Lobe attachment (rater-scored or self-reported); CESC trans rs10506458 0.834 rs17738403 chr12:63389200 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -17.85 -0.74 2.4e-47 Hemostatic factors and hematological phenotypes; CESC cis rs7927592 0.731 rs7108376 chr11:68347870 A/G cg20283391 chr11:68216788 NA 0.42 5.24 0.31 3.21e-7 Total body bone mineral density; CESC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg19346786 chr7:2764209 NA -0.39 -5.67 -0.33 3.81e-8 Height; CESC cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg03433033 chr1:76189801 ACADM -0.63 -6.61 -0.38 2.14e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.81 11.01 0.56 1.89e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9522267 0.535 rs914036 chr13:112235542 G/A cg10483660 chr13:112241077 NA -0.33 -5.78 -0.33 2.14e-8 Hepatitis; CESC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg18402987 chr7:1209562 NA 0.4 5.19 0.3 4.14e-7 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06431105 chr19:18572378 ELL -0.54 -6.36 -0.36 8.92e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26339992 chr1:28241106 RPA2 0.64 7.0 0.4 2.07e-11 Gut microbiome composition (summer); CESC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg16049864 chr8:95962084 TP53INP1 0.63 9.82 0.52 1.33e-19 Type 2 diabetes; CESC cis rs698813 0.674 rs3738985 chr2:44502788 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.08 0.3 7.17e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg12963246 chr6:28129442 ZNF389 0.56 7.62 0.42 4.43e-13 Depression; CESC cis rs10504229 0.679 rs78941440 chr8:58052095 A/G cg22535103 chr8:58192502 C8orf71 -0.63 -7.09 -0.4 1.25e-11 Developmental language disorder (linguistic errors); CESC cis rs6460942 1.000 rs7796485 chr7:12405676 G/A cg10578991 chr7:12443926 VWDE -0.55 -5.86 -0.34 1.36e-8 Coronary artery disease; CESC cis rs9902453 0.791 rs3115090 chr17:28035014 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.76 10.4 0.54 1.88e-21 Coffee consumption (cups per day); CESC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg24675658 chr1:53192096 ZYG11B -0.53 -6.96 -0.39 2.74e-11 Monocyte count; CESC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg08470875 chr2:26401718 FAM59B -0.48 -5.29 -0.31 2.56e-7 Gut microbiome composition (summer); CESC cis rs61332075 0.518 rs72994950 chr2:239422993 T/C cg18131467 chr2:239335373 ASB1 -0.72 -5.45 -0.32 1.18e-7 Lung function (FEV1/FVC); CESC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg16405210 chr4:1374714 KIAA1530 -0.45 -5.99 -0.35 6.91e-9 Longevity; CESC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.14 0.3 5.43e-7 Menopause (age at onset); CESC cis rs6502050 0.835 rs4499294 chr17:80148346 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.59e-10 Life satisfaction; CESC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.5 -0.37 3.98e-10 Bipolar disorder; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg21411534 chr10:93558674 TNKS2 0.45 6.14 0.35 3.02e-9 Systemic lupus erythematosus; CESC cis rs7264396 0.790 rs2425115 chr20:34322418 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.61 0.42 4.76e-13 Total cholesterol levels; CESC trans rs1506636 0.924 rs4370458 chr7:123260968 G/A cg12383159 chr11:1262597 MUC5B 0.36 6.07 0.35 4.36e-9 Plateletcrit;Platelet count; CESC cis rs763121 0.962 rs909564 chr22:39126508 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.88 0.62 8.54e-30 Menopause (age at onset); CESC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC cis rs9488822 0.676 rs12202641 chr6:116314634 A/G cg05304507 chr6:116381966 FRK -0.25 -6.35 -0.36 9.05e-10 Cholesterol, total;LDL cholesterol; CESC cis rs3020736 0.500 rs6002616 chr22:42504679 A/G cg04733989 chr22:42467013 NAGA -0.83 -12.49 -0.61 1.9e-28 Autism spectrum disorder or schizophrenia; CESC cis rs7584330 0.554 rs6705908 chr2:238433965 A/G cg14458575 chr2:238380390 NA 0.39 5.14 0.3 5.25e-7 Prostate cancer; CESC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg17221315 chr6:27791827 HIST1H4J 0.45 5.83 0.34 1.62e-8 Cardiac Troponin-T levels; CESC cis rs7953508 0.506 rs10777530 chr12:93961110 C/T cg18151635 chr12:93972918 NA -0.42 -5.62 -0.33 4.86e-8 Pubertal anthropometrics; CESC cis rs4819052 0.788 rs35323494 chr21:46703739 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.59 7.46 0.42 1.22e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs262150 0.503 rs11769917 chr7:158817498 C/T cg19418458 chr7:158789849 NA -0.41 -6.22 -0.36 1.91e-9 Facial morphology (factor 20); CESC cis rs7116495 0.609 rs17161751 chr11:71688347 G/A cg07596299 chr11:71824057 C11orf51 0.83 5.19 0.3 4.24e-7 Severe influenza A (H1N1) infection; CESC cis rs644799 1.000 rs564675 chr11:95561873 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.57e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg13902645 chr11:5959945 NA -0.6 -7.24 -0.41 4.72e-12 DNA methylation (variation); CESC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.27 0.31 2.88e-7 Tonsillectomy; CESC cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.46 5.28 0.31 2.74e-7 Multiple sclerosis; CESC cis rs9457247 1.000 rs429083 chr6:167383972 T/C cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 5.12e-16 Crohn's disease; CESC cis rs6570726 0.935 rs452552 chr6:145820781 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10883723 0.737 rs7074444 chr10:104249922 A/G ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.1 0.3 6.33e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs9910055 0.664 rs433610 chr17:42197281 A/G cg13607699 chr17:42295918 UBTF -0.67 -9.12 -0.49 2.01e-17 Total body bone mineral density; CESC cis rs6570726 0.967 rs439017 chr6:145806123 T/C cg05347473 chr6:146136440 FBXO30 0.42 5.66 0.33 3.89e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs660899 0.595 rs37453 chr1:44295047 A/G cg11704212 chr1:44303111 ST3GAL3 -0.39 -5.16 -0.3 4.95e-7 Hypertension risk in short sleep duration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24407859 chr22:43411083 NA 0.56 6.34 0.36 9.78e-10 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs10462755 chr5:246748 T/C cg22496380 chr5:211416 CCDC127 -0.75 -8.7 -0.47 3.49e-16 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00304673 chr4:187112763 CYP4V2 0.59 6.55 0.37 2.99e-10 Gut microbiome composition (summer); CESC cis rs4737010 0.501 rs7000282 chr8:41647493 A/C cg08923054 chr8:41654455 ANK1 0.61 7.61 0.42 4.95e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs3126085 0.935 rs1552993 chr1:152171483 A/G cg26876637 chr1:152193138 HRNR 0.44 5.11 0.3 6.25e-7 Atopic dermatitis; CESC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg00815214 chr21:47717953 NA 0.45 6.15 0.35 2.84e-9 Testicular germ cell tumor; CESC cis rs734999 0.588 rs3001837 chr1:2532506 G/A cg18854424 chr1:2615690 NA -0.28 -5.34 -0.31 1.99e-7 Ulcerative colitis; CESC cis rs3857067 1.000 rs899133 chr4:95019609 T/C cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.05e-14 QT interval; CESC cis rs6987853 0.563 rs2923406 chr8:42448873 G/T cg09913449 chr8:42400586 C8orf40 0.34 5.37 0.31 1.71e-7 Mean corpuscular hemoglobin concentration; CESC trans rs7980799 0.682 rs10161491 chr12:33623806 T/C cg26384229 chr12:38710491 ALG10B -0.58 -8.26 -0.45 7.19e-15 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs2439831 0.850 rs28524541 chr15:44124831 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.63 5.69 0.33 3.28e-8 Lung cancer in ever smokers; CESC cis rs12200560 0.505 rs211177 chr6:97074088 C/T cg06623918 chr6:96969491 KIAA0776 0.52 6.65 0.38 1.71e-10 Coronary heart disease; CESC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg05564831 chr3:52568323 NT5DC2 -0.43 -6.43 -0.37 5.77e-10 Bipolar disorder; CESC cis rs1801251 1.000 rs2305137 chr2:233712049 G/A cg25237894 chr2:233734115 C2orf82 -0.47 -8.47 -0.46 1.66e-15 Coronary artery disease; CESC cis rs1413885 0.538 rs1570869 chr1:65830905 A/C cg14976592 chr1:65886160 LEPROT;LEPR 0.43 5.44 0.32 1.2e-7 Anticoagulant levels; CESC cis rs11745587 0.539 rs6897597 chr5:131743465 C/T cg00255919 chr5:131827918 IRF1 0.38 5.99 0.35 6.81e-9 Asthma; CESC cis rs6545883 0.965 rs1992765 chr2:61751333 A/G cg15711740 chr2:61764176 XPO1 -0.43 -5.22 -0.31 3.63e-7 Tuberculosis; CESC cis rs3026101 0.624 rs1058383 chr17:5288203 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.93 0.34 9.58e-9 Body mass index; CESC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg27535305 chr1:53392650 SCP2 0.35 6.14 0.35 3.05e-9 Monocyte count; CESC cis rs11098499 0.866 rs12499602 chr4:120284387 T/A cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg16325326 chr1:53192061 ZYG11B -0.71 -11.75 -0.59 6.35e-26 Monocyte count; CESC cis rs780096 0.647 rs11682083 chr2:27752296 A/G cg22903471 chr2:27725779 GCKR -0.52 -7.15 -0.4 8.3e-12 Total body bone mineral density; CESC cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.83 8.86 0.48 1.15e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7845219 0.544 rs10956930 chr8:95919786 C/G cg23172400 chr8:95962367 TP53INP1 -0.37 -6.78 -0.38 7.89e-11 Type 2 diabetes; CESC cis rs35096708 1.000 rs35096708 chr16:89887249 G/A cg02875869 chr16:89901417 SPIRE2 -0.47 -5.97 -0.34 7.78e-9 Skin aging (microtopography measurement); CESC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg09658497 chr7:2847517 GNA12 -0.35 -5.09 -0.3 6.89e-7 Height; CESC cis rs116979167 0.575 rs67661063 chr7:105187259 T/G cg13798780 chr7:105162888 PUS7 0.52 6.34 0.36 9.9e-10 Bipolar disorder (body mass index interaction); CESC cis rs9929218 1.000 rs4500718 chr16:68754312 A/G cg02972257 chr16:68554789 NA 0.53 6.25 0.36 1.67e-9 Colorectal cancer; CESC cis rs11122272 0.735 rs2739516 chr1:231505527 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs11203032 0.831 rs10887921 chr10:90925667 T/G cg16672925 chr10:90967113 CH25H 0.71 6.72 0.38 1.12e-10 Heart failure; CESC cis rs4243830 0.850 rs12410405 chr1:6581283 C/G cg05709478 chr1:6581295 PLEKHG5 0.48 5.41 0.32 1.44e-7 Body mass index; CESC cis rs7071206 0.947 rs716255 chr10:79419679 A/T cg23888215 chr10:79422304 NA -0.51 -5.49 -0.32 9.26e-8 Bone mineral density; CESC cis rs60843830 1.000 rs79716074 chr2:277003 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.89 12.09 0.6 4.21e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.7 0.38 1.23e-10 Electroencephalogram traits; CESC cis rs9309473 0.519 rs1083922 chr2:73704003 A/G cg20560298 chr2:73613845 ALMS1 0.48 6.88 0.39 4.22e-11 Metabolite levels; CESC cis rs3540 0.512 rs3862437 chr15:91084632 A/G cg10434728 chr15:90938212 IQGAP1 -0.41 -7.1 -0.4 1.13e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1847202 0.787 rs13071878 chr3:72951084 G/A cg10804678 chr3:72788309 NA -0.41 -5.37 -0.31 1.72e-7 Motion sickness; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05129591 chr1:43637803 WDR65;EBNA1BP2 0.45 6.13 0.35 3.17e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs929354 1.000 rs1182413 chr7:157058557 G/A cg05182265 chr7:156933206 UBE3C 0.45 6.21 0.36 2.07e-9 Body mass index; CESC trans rs55704346 0.566 rs28658549 chr4:25397036 T/G cg01822600 chr1:245751692 KIF26B 0.42 6.12 0.35 3.41e-9 Tonsillectomy; CESC cis rs5753618 0.583 rs2273249 chr22:31836486 T/C cg02404636 chr22:31891804 SFI1 0.41 5.6 0.33 5.26e-8 Colorectal cancer; CESC cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg17971929 chr21:40555470 PSMG1 0.59 7.63 0.42 4.25e-13 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08847296 chr1:155278656 FDPS 0.57 7.05 0.4 1.51e-11 Gut microbiome composition (summer); CESC cis rs5753037 0.653 rs140102 chr22:30128443 T/C cg01021169 chr22:30184971 ASCC2 -0.42 -5.79 -0.33 2.04e-8 Type 1 diabetes; CESC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg07092213 chr7:1199455 ZFAND2A -0.41 -5.44 -0.32 1.2e-7 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05227288 chr16:32489822 NA -0.53 -6.25 -0.36 1.66e-9 Gut microbiome composition (summer); CESC cis rs12477438 0.561 rs2084988 chr2:99655755 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs933688 1.000 rs6865495 chr5:90746424 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.1 14.79 0.67 1.71e-36 Smoking behavior; CESC cis rs4566357 0.595 rs1320406 chr2:227920474 C/T cg05526886 chr2:227700861 RHBDD1 -0.46 -6.2 -0.36 2.19e-9 Coronary artery disease; CESC cis rs6740322 0.895 rs11684601 chr2:43574242 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -7.18 -0.4 7e-12 Coronary artery disease; CESC cis rs12410462 0.579 rs78343168 chr1:227621090 G/A cg23173402 chr1:227635558 NA 0.74 6.78 0.38 7.9e-11 Major depressive disorder; CESC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.25 0.53 5.71e-21 Prudent dietary pattern; CESC cis rs8077577 0.708 rs7211573 chr17:18131613 T/C cg16794390 chr17:18148240 FLII -0.43 -6.33 -0.36 1.04e-9 Obesity-related traits; CESC cis rs4906332 1.000 rs55930273 chr14:103960298 G/A cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.49e-10 Coronary artery disease; CESC cis rs6964587 0.773 rs10488514 chr7:91951842 C/A cg17063962 chr7:91808500 NA 0.54 6.81 0.39 6.41e-11 Breast cancer; CESC cis rs796364 1.000 rs281763 chr2:200794870 C/T cg23649088 chr2:200775458 C2orf69 0.54 5.33 0.31 2.13e-7 Schizophrenia; CESC cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg19193384 chr17:30244184 NA -0.67 -6.36 -0.36 8.74e-10 Hip circumference adjusted for BMI; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg22515636 chr2:109150313 NA -0.53 -7.07 -0.4 1.37e-11 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24729617 chr1:165551210 LOC400794 -0.69 -8.12 -0.45 1.78e-14 Gut microbiome composition (summer); CESC cis rs1018836 0.886 rs10956750 chr8:91621704 G/C cg16814680 chr8:91681699 NA -0.72 -10.09 -0.53 1.82e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg09323728 chr8:95962352 TP53INP1 -0.35 -7.39 -0.41 1.88e-12 Type 2 diabetes; CESC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg23978390 chr7:1156363 C7orf50 0.59 8.17 0.45 1.24e-14 Longevity;Endometriosis; CESC cis rs9611565 1.000 rs1109151 chr22:41752944 A/G cg03806693 chr22:41940476 POLR3H -0.75 -9.04 -0.49 3.38e-17 Vitiligo; CESC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs12477438 0.520 rs4850897 chr2:99768419 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.63 0.61 6.22e-29 Chronic sinus infection; CESC cis rs12530845 0.832 rs56306315 chr7:135329107 C/T cg23117316 chr7:135346802 PL-5283 -0.41 -5.29 -0.31 2.52e-7 Red blood cell traits; CESC cis rs7071206 0.947 rs10824560 chr10:79416901 C/T cg23888215 chr10:79422304 NA -0.52 -5.65 -0.33 4.17e-8 Bone mineral density; CESC cis rs6912958 0.559 rs242279 chr6:88048191 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.72 10.99 0.56 2.06e-23 Monocyte percentage of white cells; CESC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg00149659 chr3:10157352 C3orf10 0.7 8.47 0.46 1.68e-15 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23329543 chr19:53432372 ZNF321 0.43 6.31 0.36 1.17e-9 Fibrinogen levels; CESC cis rs1559088 0.600 rs7256470 chr19:33558085 C/A cg27124370 chr19:33622961 WDR88 0.53 7.47 0.42 1.19e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg14983838 chr19:29218262 NA 0.39 5.24 0.31 3.3e-7 Methadone dose in opioid dependence; CESC cis rs2070997 0.607 rs2855190 chr9:133708361 C/T cg11464064 chr9:133710261 ABL1 -0.69 -8.15 -0.45 1.43e-14 Response to amphetamines; CESC cis rs4727027 0.901 rs11760293 chr7:148811725 A/G cg23158103 chr7:148848205 ZNF398 -0.41 -6.75 -0.38 9.31e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs637571 0.544 rs500161 chr11:65695438 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 5.78 0.33 2.07e-8 Eosinophil percentage of white cells; CESC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg17376030 chr22:41985996 PMM1 -0.77 -8.15 -0.45 1.45e-14 Vitiligo; CESC cis rs977987 0.843 rs11644741 chr16:75466433 C/A cg03315344 chr16:75512273 CHST6 0.41 5.93 0.34 9.5e-9 Dupuytren's disease; CESC cis rs10208940 0.920 rs6751531 chr2:68794528 G/T cg12452813 chr2:68675892 NA 0.52 5.25 0.31 3.12e-7 Urate levels in lean individuals; CESC cis rs12618769 0.597 rs72819986 chr2:99045867 G/C cg10123293 chr2:99228465 UNC50 0.39 5.18 0.3 4.49e-7 Bipolar disorder; CESC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg16928487 chr17:17741425 SREBF1 0.63 11.05 0.56 1.39e-23 Total body bone mineral density; CESC cis rs4073405 0.584 rs7395419 chr11:45309171 G/A cg27235148 chr11:45376932 NA 0.29 5.03 0.3 9.22e-7 Schizophrenia; CESC cis rs17125944 0.615 rs7151474 chr14:53313680 C/T cg00686598 chr14:53173677 PSMC6 -0.56 -5.08 -0.3 7.1e-7 Alzheimer's disease (late onset); CESC cis rs34779708 0.931 rs7908573 chr10:35309513 T/C cg04310649 chr10:35416472 CREM -0.48 -5.84 -0.34 1.53e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg20476274 chr7:133979776 SLC35B4 0.6 8.54 0.46 1.04e-15 Mean platelet volume; CESC cis rs2790457 0.958 rs2772431 chr10:28890160 C/T cg04045419 chr10:28823091 WAC -0.43 -5.17 -0.3 4.63e-7 Multiple myeloma; CESC cis rs1707322 0.964 rs1707339 chr1:46513179 A/G cg03146154 chr1:46216737 IPP -0.72 -9.73 -0.51 2.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17039065 1.000 rs72889361 chr4:109381063 T/G cg16022748 chr4:109541635 LOC285456;RPL34 0.6 5.06 0.3 8.01e-7 Gut microbiome composition (summer); CESC cis rs7809950 1.000 rs2520249 chr7:107146748 A/G cg23024343 chr7:107201750 COG5 -0.42 -5.91 -0.34 1.05e-8 Coronary artery disease; CESC cis rs9486719 0.947 rs9398072 chr6:96911304 T/C cg06623918 chr6:96969491 KIAA0776 0.89 10.42 0.54 1.6e-21 Migraine;Coronary artery disease; CESC cis rs1957429 0.901 rs3813422 chr14:65347404 G/A cg23373153 chr14:65346875 NA 0.96 11.49 0.58 4.43e-25 Pediatric areal bone mineral density (radius); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22118131 chr15:78369834 TBC1D2B 0.55 7.4 0.41 1.86e-12 Gut microbiota (bacterial taxa); CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.33 6.49 0.37 4.17e-10 Bipolar disorder; CESC cis rs910316 0.967 rs175479 chr14:75561871 A/C cg08847533 chr14:75593920 NEK9 -0.97 -18.54 -0.75 9.05e-50 Height; CESC cis rs6543140 0.964 rs918000 chr2:103067862 C/T cg04239558 chr2:103089729 SLC9A4 0.45 5.66 0.33 3.94e-8 Blood protein levels; CESC cis rs7631605 0.875 rs7616105 chr3:37229522 G/A cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.24 -0.31 3.3e-7 Cerebrospinal P-tau181p levels; CESC cis rs6580649 0.941 rs7963934 chr12:48477086 C/G cg05342945 chr12:48394962 COL2A1 0.5 5.74 0.33 2.59e-8 Lung cancer; CESC cis rs11722228 1.000 rs4697695 chr4:9915850 C/T cg00071950 chr4:10020882 SLC2A9 0.56 8.2 0.45 1.04e-14 Gout;Urate levels;Serum uric acid levels; CESC cis rs7647973 0.626 rs4855846 chr3:49683526 G/A cg03060546 chr3:49711283 APEH 0.68 8.3 0.45 5.3e-15 Menarche (age at onset); CESC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.14 0.4 8.95e-12 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20088969 chr10:74032886 DDIT4 0.55 6.46 0.37 4.92e-10 Gut microbiome composition (summer); CESC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg12463550 chr7:65579703 CRCP 0.49 6.33 0.36 1.03e-9 Aortic root size; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04677295 chr13:100153866 TM9SF2 0.46 6.45 0.37 5.29e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10927534 chr5:141392688 GNPDA1 0.56 6.01 0.35 6.06e-9 Gut microbiome composition (summer); CESC cis rs79349575 0.749 rs519537 chr17:46971140 G/A cg16584676 chr17:46985605 UBE2Z 0.54 6.64 0.38 1.76e-10 Type 2 diabetes; CESC cis rs17666538 0.535 rs1669613 chr8:617565 G/C cg02524346 chr8:600233 NA 0.86 6.17 0.35 2.53e-9 IgG glycosylation; CESC cis rs7599312 0.534 rs6735626 chr2:213403972 G/A cg20637307 chr2:213403960 ERBB4 0.57 8.92 0.48 7.78e-17 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg21248554 chr2:27665150 KRTCAP3 -0.29 -6.18 -0.36 2.37e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs9815354 1.000 rs17062109 chr3:41810364 C/T cg03022575 chr3:42003672 ULK4 0.49 5.42 0.32 1.32e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg22875332 chr1:76189707 ACADM 0.6 6.86 0.39 4.79e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg27211696 chr2:191398769 TMEM194B 0.52 7.62 0.42 4.53e-13 Pulse pressure; CESC trans rs10435719 0.834 rs6985792 chr8:11795335 T/C cg15556689 chr8:8085844 FLJ10661 0.49 6.09 0.35 3.95e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs11638352 1.000 rs11854312 chr15:44279709 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.53 -5.46 -0.32 1.09e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs7520050 0.966 rs10890352 chr1:46283628 G/A cg03146154 chr1:46216737 IPP -0.47 -6.19 -0.36 2.34e-9 Red blood cell count;Reticulocyte count; CESC cis rs12136530 0.774 rs10158117 chr1:19766747 G/C cg01832549 chr1:19774989 CAPZB -0.47 -6.57 -0.37 2.65e-10 Lead levels in blood; CESC cis rs3015497 0.763 rs2934689 chr14:51118327 A/C cg09863266 chr14:51125203 SAV1 -0.34 -5.34 -0.31 1.98e-7 Mean platelet volume; CESC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg14393609 chr7:65229607 NA -0.47 -6.3 -0.36 1.24e-9 Aortic root size; CESC cis rs15676 0.783 rs2280845 chr9:131583170 T/C cg00228799 chr9:131580591 ENDOG 0.54 6.9 0.39 3.73e-11 Blood metabolite levels; CESC cis rs796364 0.806 rs11679658 chr2:200923081 A/G cg23649088 chr2:200775458 C2orf69 -0.58 -5.23 -0.31 3.38e-7 Schizophrenia; CESC cis rs57221529 0.766 rs72703075 chr5:592819 C/T cg16447950 chr5:562315 NA -0.6 -5.7 -0.33 3.2e-8 Lung disease severity in cystic fibrosis; CESC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.03e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03084103 chr4:38869707 MIR574;FAM114A1 -0.51 -6.32 -0.36 1.08e-9 Gut microbiome composition (summer); CESC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg06456125 chr7:65229604 NA -0.4 -5.58 -0.32 5.96e-8 Aortic root size; CESC cis rs4409675 0.576 rs11247705 chr1:28212272 G/A cg23691781 chr1:28212827 C1orf38 0.28 5.67 0.33 3.79e-8 Corneal astigmatism; CESC cis rs903027 0.752 rs16927470 chr8:62458019 A/G cg06626168 chr8:61834373 NA -0.35 -5.14 -0.3 5.37e-7 Whole-brain volume; CESC cis rs7680126 0.633 rs11730631 chr4:10292968 C/T cg11266682 chr4:10021025 SLC2A9 0.42 5.68 0.33 3.58e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs9549367 1.000 rs9549367 chr13:113911532 C/G cg18105134 chr13:113819100 PROZ -0.62 -7.62 -0.42 4.55e-13 Platelet distribution width; CESC cis rs3858526 0.959 rs10838795 chr11:5920721 A/G cg13902645 chr11:5959945 NA 0.58 7.07 0.4 1.38e-11 DNA methylation (variation); CESC trans rs61931739 0.500 rs9795938 chr12:34587739 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.43 -0.42 1.46e-12 Morning vs. evening chronotype; CESC cis rs7937682 0.632 rs7128862 chr11:111755435 C/T cg22437258 chr11:111473054 SIK2 -0.5 -5.53 -0.32 7.6e-8 Primary sclerosing cholangitis; CESC trans rs7922314 0.571 rs61865715 chr10:64737789 C/T cg06935979 chr1:232941706 KIAA1383 -0.63 -6.09 -0.35 3.89e-9 Cutaneous psoriasis; CESC trans rs945270 0.512 rs17128756 chr14:56192794 G/A cg18102697 chr4:83542773 C4orf11 -0.42 -6.32 -0.36 1.11e-9 Subcortical brain region volumes; CESC cis rs10504229 0.636 rs115738451 chr8:58055133 A/T cg21724239 chr8:58056113 NA 0.57 5.41 0.32 1.41e-7 Developmental language disorder (linguistic errors); CESC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.6 7.93 0.44 6.25e-14 Menopause (age at onset); CESC cis rs17253792 0.822 rs78395034 chr14:56069783 G/A cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg08968635 chr6:28129556 ZNF389 -0.42 -5.77 -0.33 2.17e-8 Depression; CESC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.35 0.36 9.21e-10 Bipolar disorder; CESC trans rs9834373 0.573 rs36083074 chr3:78525501 A/G cg21593409 chr16:88706389 IL17C -0.42 -6.04 -0.35 5.2e-9 Protein quantitative trait loci; CESC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg18337363 chr3:52569053 NT5DC2 0.29 5.15 0.3 5.16e-7 Bipolar disorder; CESC cis rs2290405 0.527 rs6829987 chr4:932974 C/G cg04824913 chr4:887549 GAK -0.68 -8.87 -0.48 1.13e-16 Systemic sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05494152 chr7:75544339 POR 0.57 6.88 0.39 4.41e-11 Gut microbiome composition (summer); CESC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg27535305 chr1:53392650 SCP2 -0.34 -5.86 -0.34 1.33e-8 Monocyte count; CESC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg26338869 chr17:61819248 STRADA 0.69 9.11 0.49 2.04e-17 Prudent dietary pattern; CESC cis rs10885582 0.781 rs10885571 chr10:116293421 T/G cg17056676 chr10:116301354 ABLIM1 -0.28 -5.05 -0.3 8.15e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs9796 0.870 rs7162992 chr15:41290861 T/C cg18705301 chr15:41695430 NDUFAF1 -0.47 -7.11 -0.4 1.08e-11 Menopause (age at onset); CESC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg07677032 chr17:61819896 STRADA 0.44 5.86 0.34 1.36e-8 Prudent dietary pattern; CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg00026222 chr1:2144244 NA 0.47 6.21 0.36 2.04e-9 Prevalent atrial fibrillation; CESC cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.15e-15 Colonoscopy-negative controls vs population controls; CESC cis rs10416265 0.527 rs6510337 chr19:33545701 C/T cg03563238 chr19:33554763 RHPN2 -0.31 -5.48 -0.32 9.82e-8 Bone properties (heel); CESC cis rs4901869 0.966 rs1820557 chr14:59334863 C/G cg02291164 chr14:59296302 NA 0.45 7.73 0.43 2.21e-13 Panic disorder; CESC cis rs7072216 0.763 rs6584205 chr10:100173806 C/T cg26618903 chr10:100175079 PYROXD2 -0.38 -5.85 -0.34 1.41e-8 Metabolite levels; CESC cis rs1691799 0.899 rs1168320 chr12:66744849 C/T cg16791601 chr12:66731901 HELB -0.79 -14.34 -0.66 6.63e-35 White blood cell count (basophil); CESC cis rs2120019 0.935 rs8042409 chr15:75350433 G/A cg17294928 chr15:75287854 SCAMP5 -0.65 -7.04 -0.4 1.67e-11 Blood trace element (Zn levels); CESC cis rs17433780 0.860 rs61798916 chr1:89493957 G/A cg09516651 chr1:89888402 LOC400759 0.68 9.49 0.5 1.43e-18 Carotid intima media thickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01980454 chr1:859173 NA 0.54 6.18 0.35 2.41e-9 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg23758822 chr17:41437982 NA 1.0 14.9 0.68 6.88e-37 Menopause (age at onset); CESC cis rs2281558 0.793 rs6115227 chr20:25591377 A/C cg24626310 chr20:25276739 ABHD12;PYGB 0.51 6.91 0.39 3.68e-11 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg25405998 chr7:65216604 CCT6P1 -0.5 -5.28 -0.31 2.64e-7 Aortic root size; CESC cis rs2228479 0.867 rs11642451 chr16:89958127 T/C cg00800038 chr16:89945340 TCF25 -0.87 -7.73 -0.43 2.3e-13 Skin colour saturation; CESC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg06420487 chr17:61919686 SMARCD2 0.46 5.59 0.32 5.67e-8 Height; CESC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg07414643 chr4:187882934 NA 0.54 7.97 0.44 4.82e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg21782813 chr7:2030301 MAD1L1 0.41 5.78 0.33 2.1e-8 Schizophrenia; CESC cis rs4713675 0.565 rs4713659 chr6:33667839 A/G cg15676125 chr6:33679581 C6orf125 0.33 5.05 0.3 8.31e-7 Plateletcrit; CESC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg22467129 chr15:76604101 ETFA -0.39 -6.05 -0.35 5.01e-9 Blood metabolite levels; CESC cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg25554036 chr4:6271136 WFS1 0.52 8.41 0.46 2.62e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.49 -6.23 -0.36 1.79e-9 Personality dimensions; CESC cis rs4803468 0.967 rs3826713 chr19:41892269 C/T cg09537434 chr19:41945824 ATP5SL -1.02 -18.19 -0.75 1.57e-48 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16986746 chr3:48594219 PFKFB4 0.57 6.02 0.35 5.92e-9 Gut microbiome composition (summer); CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg27094323 chr7:1216898 NA -0.44 -6.38 -0.36 7.83e-10 Longevity;Endometriosis; CESC cis rs3816788 0.792 rs729180 chr8:21817245 C/T cg17168535 chr8:21777572 XPO7 0.74 11.86 0.59 2.55e-26 Lung cancer in ever smokers; CESC cis rs79349575 0.681 rs56080003 chr17:47019049 A/T cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs1941023 0.503 rs7944025 chr11:60142538 C/A cg08716584 chr11:60157161 MS4A7 -0.57 -9.44 -0.5 1.96e-18 Congenital heart disease (maternal effect); CESC trans rs61931739 0.517 rs4931748 chr12:34140827 C/T cg26384229 chr12:38710491 ALG10B 0.6 8.3 0.45 5.26e-15 Morning vs. evening chronotype; CESC cis rs28647808 0.881 rs41316984 chr9:136259231 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs2273669 0.667 rs2145763 chr6:109306963 C/A cg05315195 chr6:109294784 ARMC2 -0.65 -5.82 -0.34 1.71e-8 Prostate cancer; CESC trans rs17764205 0.929 rs8112130 chr19:3253928 A/G cg19548313 chr19:1065712 HMHA1 0.48 6.09 0.35 3.87e-9 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4233802 1.000 rs11895581 chr2:151125904 A/G cg25300694 chr2:151184358 NA 0.9 7.5 0.42 9.95e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs1784581 0.588 rs1784606 chr6:162405992 A/T cg17173639 chr6:162384350 PARK2 -0.44 -6.27 -0.36 1.47e-9 Itch intensity from mosquito bite; CESC cis rs1728785 0.748 rs889560 chr16:68605784 A/G cg02972257 chr16:68554789 NA -0.59 -6.71 -0.38 1.2e-10 Ulcerative colitis; CESC cis rs6665290 0.901 rs2104860 chr1:227208637 G/C cg10327440 chr1:227177885 CDC42BPA -1.16 -24.88 -0.84 2.83e-71 Myeloid white cell count; CESC cis rs72781680 0.799 rs17508218 chr2:23976536 C/T cg08917208 chr2:24149416 ATAD2B 0.96 8.7 0.47 3.55e-16 Lymphocyte counts; CESC cis rs73206853 0.764 rs7980838 chr12:110672978 T/A cg12870014 chr12:110450643 ANKRD13A 0.73 6.55 0.37 2.98e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs56104184 0.779 rs17206686 chr19:49356317 A/G cg15549821 chr19:49342101 PLEKHA4 -0.78 -9.0 -0.48 4.37e-17 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15207091 chr17:4795168 MINK1 -0.59 -7.2 -0.4 6.03e-12 Gut microbiome composition (summer); CESC cis rs9457247 0.902 rs34560498 chr6:167395862 A/G cg07741184 chr6:167504864 NA 0.29 5.21 0.3 3.78e-7 Crohn's disease; CESC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg27170947 chr2:26402098 FAM59B -0.71 -8.27 -0.45 6.5e-15 Gut microbiome composition (summer); CESC cis rs870825 0.616 rs28582728 chr4:185646920 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs1707322 0.964 rs10437063 chr1:46273666 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.75 0.33 2.42e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg11247378 chr22:39784982 NA -0.62 -9.02 -0.48 4.03e-17 Intelligence (multi-trait analysis); CESC cis rs5769765 1.000 rs8184990 chr22:50273174 A/G cg02269571 chr22:50332266 NA 0.47 6.38 0.36 7.99e-10 Schizophrenia; CESC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg23708337 chr7:1209742 NA 0.53 5.74 0.33 2.54e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7264396 0.790 rs6060541 chr20:34248066 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 3.14e-26 Total cholesterol levels; CESC cis rs1499614 1.000 rs2707832 chr7:66136549 C/T cg18252515 chr7:66147081 NA -1.39 -13.77 -0.65 6.55e-33 Gout; CESC cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24677674 chr10:113943468 GPAM -0.48 -6.92 -0.39 3.33e-11 Gambling; CESC cis rs483180 0.512 rs612430 chr1:120216025 A/G cg19096424 chr1:120255104 PHGDH 0.42 5.13 0.3 5.49e-7 Macular telangiectasia type 2; CESC cis rs7949030 0.588 rs2512562 chr11:62312156 A/G cg22862634 chr11:62369728 EML3;MTA2 0.49 6.89 0.39 4.13e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07715894 chr16:11439533 C16orf75 -0.65 -7.39 -0.41 1.92e-12 Gut microbiome composition (summer); CESC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg05313129 chr8:58192883 C8orf71 -0.5 -5.05 -0.3 8.06e-7 Developmental language disorder (linguistic errors); CESC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg23281280 chr6:28129359 ZNF389 0.6 8.04 0.44 2.95e-14 Depression; CESC cis rs6546550 0.901 rs11902198 chr2:70144596 C/A cg02498382 chr2:70120550 SNRNP27 -0.41 -7.26 -0.41 4.34e-12 Prevalent atrial fibrillation; CESC cis rs2797685 1.000 rs707472 chr1:7906008 A/C cg04725166 chr1:7887271 PER3 0.46 6.31 0.36 1.19e-9 Crohn's disease; CESC cis rs3733585 0.699 rs6844787 chr4:9959233 A/G cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2243480 1.000 rs402418 chr7:65509469 G/A cg13147721 chr7:65941812 NA -0.95 -9.04 -0.49 3.39e-17 Diabetic kidney disease; CESC cis rs7917772 0.503 rs2031601 chr10:104308064 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.56 7.87 0.44 9.28e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6963495 0.818 rs116845562 chr7:105217038 T/C cg13798780 chr7:105162888 PUS7 0.74 7.4 0.41 1.79e-12 Bipolar disorder (body mass index interaction); CESC cis rs854765 0.583 rs11078404 chr17:17820487 A/T cg04398451 chr17:18023971 MYO15A -0.67 -9.74 -0.51 2.33e-19 Total body bone mineral density; CESC cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg12927641 chr6:109611667 NA -0.42 -6.45 -0.37 5.22e-10 Reticulocyte fraction of red cells; CESC cis rs10905065 0.895 rs3736462 chr10:5804455 A/G cg11519256 chr10:5708881 ASB13 0.44 5.87 0.34 1.28e-8 Menopause (age at onset); CESC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg24675658 chr1:53192096 ZYG11B 0.77 11.82 0.59 3.5e-26 Monocyte count; CESC cis rs9815354 0.680 rs73830596 chr3:42028223 G/A cg03022575 chr3:42003672 ULK4 0.72 6.4 0.37 6.9e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs9300255 0.602 rs949142 chr12:123634043 T/C cg00376283 chr12:123451042 ABCB9 0.71 8.76 0.47 2.38e-16 Neutrophil percentage of white cells; CESC cis rs6032067 1.000 rs35284867 chr20:43845836 A/T cg10761708 chr20:43804764 PI3 0.5 5.87 0.34 1.28e-8 Blood protein levels; CESC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg23161317 chr6:28129485 ZNF389 -0.49 -6.18 -0.35 2.41e-9 Depression; CESC cis rs854765 0.583 rs4925125 chr17:17794444 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.46 -5.92 -0.34 9.93e-9 Total body bone mineral density; CESC cis rs858239 0.796 rs433395 chr7:23401955 G/T cg23682824 chr7:23144976 KLHL7 0.38 5.14 0.3 5.22e-7 Cerebrospinal fluid biomarker levels; CESC cis rs12500824 0.564 rs62300858 chr4:77285721 A/C cg20311846 chr4:77356250 SHROOM3 0.37 6.86 0.39 4.82e-11 Coronary artery disease; CESC cis rs9916302 0.904 rs8065963 chr17:37681332 C/T cg07936489 chr17:37558343 FBXL20 -0.8 -11.57 -0.58 2.46e-25 Glomerular filtration rate (creatinine); CESC cis rs34779708 0.897 rs35784065 chr10:35353574 C/T cg03585969 chr10:35415529 CREM 0.73 9.4 0.5 2.63e-18 Inflammatory bowel disease;Crohn's disease; CESC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.46 7.62 0.42 4.57e-13 Monocyte percentage of white cells; CESC cis rs75229567 0.618 rs11495622 chr12:70161286 G/A cg10114359 chr12:70132523 RAB3IP 1.11 7.59 0.42 5.44e-13 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs863345 0.565 rs59188837 chr1:158500636 C/G cg12129480 chr1:158549410 OR10X1 -0.34 -6.76 -0.38 8.6e-11 Pneumococcal bacteremia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24504843 chr4:56896641 CEP135 0.51 6.71 0.38 1.17e-10 Fibrinogen levels; CESC cis rs61931739 0.500 rs10844862 chr12:34531965 A/T cg06521331 chr12:34319734 NA -0.37 -5.15 -0.3 5.19e-7 Morning vs. evening chronotype; CESC cis rs67311347 1.000 rs12638199 chr3:40475285 A/G cg01475735 chr3:40494733 NA -0.4 -5.08 -0.3 7.14e-7 Renal cell carcinoma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23660191 chr16:30582942 ZNF688 -0.42 -6.26 -0.36 1.57e-9 Gambling; CESC cis rs2657888 0.965 rs2694909 chr12:56934928 T/C cg23002907 chr12:56915593 RBMS2 0.39 5.19 0.3 4.12e-7 Adiponectin levels; CESC cis rs1577917 0.958 rs12212480 chr6:86458777 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.53 -6.91 -0.39 3.68e-11 Response to antipsychotic treatment; CESC cis rs1986734 0.555 rs12512288 chr4:77416817 C/G cg20311846 chr4:77356250 SHROOM3 -0.27 -5.4 -0.31 1.51e-7 Eosinophilic esophagitis (pediatric);Metabolite levels (small molecules and protein measures); CESC cis rs6968419 0.755 rs2896181 chr7:115897884 A/G cg02561103 chr7:115862891 TES 0.41 5.48 0.32 1.01e-7 Intraocular pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27620946 chr8:42011116 AP3M2 -0.46 -6.63 -0.38 1.83e-10 Gambling; CESC cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg20476274 chr7:133979776 SLC35B4 0.6 8.25 0.45 7.65e-15 Mean platelet volume; CESC trans rs11663156 0.793 rs8082807 chr18:51010902 A/C cg06077405 chr7:2313805 SNX8 -0.46 -6.07 -0.35 4.42e-9 Intelligence (multi-trait analysis); CESC cis rs941873 0.868 rs2145998 chr10:81121696 T/A cg08514558 chr10:81106712 PPIF 0.34 5.98 0.34 7.25e-9 Height; CESC cis rs79349575 0.783 rs2088139 chr17:47000110 C/T cg16584676 chr17:46985605 UBE2Z 0.53 6.58 0.37 2.46e-10 Type 2 diabetes; CESC trans rs6084875 0.641 rs6052806 chr20:4721871 A/G cg10192164 chr16:30419175 ZNF771 -0.51 -6.15 -0.35 2.78e-9 Systemic lupus erythematosus; CESC trans rs9329221 0.683 rs525726 chr8:9887797 G/C cg06636001 chr8:8085503 FLJ10661 -0.53 -7.08 -0.4 1.33e-11 Neuroticism; CESC cis rs11871801 0.517 rs646123 chr17:40720632 G/A cg14558262 chr17:40713999 COASY 0.51 5.95 0.34 8.31e-9 Crohn's disease; CESC cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg00701064 chr4:6280414 WFS1 -0.73 -12.9 -0.62 6.98e-30 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7628338 0.525 rs13072744 chr3:72509637 C/T cg16990174 chr3:72496875 RYBP -0.24 -5.59 -0.32 5.78e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC cis rs7647973 0.600 rs11920267 chr3:49275964 G/A cg07636037 chr3:49044803 WDR6 0.81 13.44 0.64 9.07e-32 Menarche (age at onset); CESC cis rs1707322 1.000 rs785490 chr1:46577124 T/C cg05343316 chr1:45956843 TESK2 -0.47 -5.52 -0.32 7.97e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs72781680 0.821 rs116583405 chr2:24208221 T/C cg08917208 chr2:24149416 ATAD2B 0.64 6.33 0.36 1.07e-9 Lymphocyte counts; CESC cis rs11645898 0.765 rs112439757 chr16:72168337 C/T cg14768367 chr16:72042858 DHODH -0.57 -5.17 -0.3 4.61e-7 Blood protein levels; CESC trans rs7088591 0.867 rs115213581 chr10:59732069 G/A cg10559231 chr5:14188039 TRIO 0.76 6.28 0.36 1.38e-9 Blood pressure; CESC cis rs929354 0.557 rs62491947 chr7:156960813 G/A cg05182265 chr7:156933206 UBE3C -0.5 -7.29 -0.41 3.49e-12 Body mass index; CESC cis rs72945132 0.882 rs11235739 chr11:70132780 C/T cg14191688 chr11:70257035 CTTN 0.4 5.29 0.31 2.56e-7 Coronary artery disease; CESC cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg08917208 chr2:24149416 ATAD2B 0.6 5.66 0.33 3.99e-8 Lymphocyte counts; CESC cis rs9297145 0.585 rs10953283 chr7:98782750 A/G cg05967295 chr7:98741636 SMURF1 0.6 8.18 0.45 1.17e-14 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg25358565 chr5:93447407 FAM172A 1.12 11.21 0.57 3.87e-24 Diabetic retinopathy; CESC cis rs654950 0.783 rs640688 chr1:42001831 A/G cg06885757 chr1:42089581 HIVEP3 -0.49 -8.02 -0.44 3.35e-14 Airway imaging phenotypes; CESC cis rs17376456 0.825 rs10057130 chr5:93282557 C/T cg25358565 chr5:93447407 FAM172A 1.11 10.04 0.53 2.56e-20 Diabetic retinopathy; CESC cis rs2276314 1.000 rs56050783 chr18:33553791 A/G cg19628046 chr18:33552617 C18orf21 0.57 6.41 0.37 6.53e-10 Endometriosis;Drug-induced torsades de pointes; CESC trans rs3780486 0.757 rs10758189 chr9:33125804 A/G cg04842962 chr6:43655489 MRPS18A 0.99 18.98 0.76 2.56e-51 IgG glycosylation; CESC cis rs79349575 0.783 rs318096 chr17:46975370 G/A cg16584676 chr17:46985605 UBE2Z 0.53 6.58 0.37 2.57e-10 Type 2 diabetes; CESC cis rs17376456 1.000 rs34854140 chr5:93538169 G/A cg25358565 chr5:93447407 FAM172A 1.16 11.45 0.58 6.45e-25 Diabetic retinopathy; CESC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg21770322 chr7:97807741 LMTK2 -0.55 -8.17 -0.45 1.31e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs3026101 0.624 rs7426 chr17:5288983 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.48 6.37 0.36 8.39e-10 Body mass index; CESC cis rs11030122 0.702 rs12286710 chr11:3967171 T/G cg18678763 chr11:4115507 RRM1 -0.45 -5.96 -0.34 7.84e-9 Mean platelet volume;Platelet distribution width; CESC cis rs9815354 1.000 rs9846634 chr3:41894049 G/A cg03022575 chr3:42003672 ULK4 0.58 5.94 0.34 9.04e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs151234 0.741 rs151230 chr16:28583215 G/A cg01378222 chr16:28622494 SULT1A1 -0.57 -7.19 -0.4 6.79e-12 Platelet distribution width; CESC cis rs733175 0.855 rs10018666 chr4:10004805 C/T cg11266682 chr4:10021025 SLC2A9 0.39 5.24 0.31 3.29e-7 Psychosis and Alzheimer's disease; CESC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg05234568 chr11:5960015 NA -0.64 -8.25 -0.45 7.47e-15 DNA methylation (variation); CESC cis rs9549367 0.789 rs9577220 chr13:113908294 T/A cg18105134 chr13:113819100 PROZ -0.68 -8.71 -0.47 3.37e-16 Platelet distribution width; CESC cis rs3733585 0.660 rs13122290 chr4:9933832 A/G cg00071950 chr4:10020882 SLC2A9 -0.73 -12.59 -0.61 8.62e-29 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9467711 0.591 rs17586553 chr6:25928775 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.57 5.27 0.31 2.82e-7 Autism spectrum disorder or schizophrenia; CESC cis rs6496667 0.532 rs2601207 chr15:90963542 C/G cg10434728 chr15:90938212 IQGAP1 -0.3 -5.2 -0.3 4.02e-7 Rheumatoid arthritis; CESC cis rs1577917 0.958 rs10806337 chr6:86474249 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -6.81 -0.39 6.5500000000000006e-11 Response to antipsychotic treatment; CESC cis rs7188697 0.848 rs37062 chr16:58567238 A/G cg21335942 chr16:58549945 SETD6 0.46 5.37 0.31 1.7e-7 QT interval; CESC cis rs7131987 0.903 rs2216853 chr12:29413248 C/G cg09582351 chr12:29534625 ERGIC2 -0.35 -5.72 -0.33 2.9e-8 QT interval; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12241299 chr14:20929705 TMEM55B 0.45 6.23 0.36 1.8e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs35110281 0.837 rs12627667 chr21:45071396 A/C cg01579765 chr21:45077557 HSF2BP -0.58 -9.91 -0.52 6.71e-20 Mean corpuscular volume; CESC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg11644478 chr21:40555479 PSMG1 -0.53 -7.14 -0.4 9.02e-12 Menarche (age at onset); CESC cis rs16973500 0.808 rs1049794 chr16:71950450 C/T cg09427745 chr16:71932006 KIAA0174 -0.52 -5.3 -0.31 2.39e-7 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs17253792 0.822 rs78432811 chr14:56051545 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.54 0.32 7.35e-8 Putamen volume; CESC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.72 6.41 0.37 6.71e-10 Platelet count; CESC cis rs11055034 0.560 rs2024385 chr12:12888438 A/T cg09462578 chr12:12878428 APOLD1 0.58 8.1 0.45 1.98e-14 Birth weight; CESC cis rs2243480 1.000 rs7778911 chr7:65694506 T/C cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs3204270 0.639 rs11871678 chr17:79654285 G/A cg26965718 chr17:79658957 HGS -0.84 -5.88 -0.34 1.25e-8 Dental caries; CESC cis rs4481887 0.927 rs7555310 chr1:248487638 A/G cg00666640 chr1:248458726 OR2T12 0.35 5.98 0.35 7.04e-9 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05380570 chr1:17866686 ARHGEF10L -0.6 -7.41 -0.41 1.74e-12 Gut microbiome composition (summer); CESC cis rs12971120 0.685 rs34780792 chr18:72173278 G/A cg26446133 chr18:72167187 CNDP2 -0.77 -9.23 -0.49 9.2e-18 Refractive error; CESC cis rs6547741 0.935 rs6547738 chr2:27852637 A/G cg27432699 chr2:27873401 GPN1 0.48 6.82 0.39 6.31e-11 Oral cavity cancer; CESC cis rs736801 0.891 rs10900809 chr5:131826322 G/A cg21138405 chr5:131827807 IRF1 -0.46 -5.99 -0.35 6.71e-9 Breast cancer;Mosquito bite size; CESC cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.15 0.3 5.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs524281 0.817 rs10791859 chr11:65978453 C/T cg14036092 chr11:66035641 RAB1B -0.58 -5.92 -0.34 9.73e-9 Electroencephalogram traits; CESC cis rs7772486 0.840 rs2814867 chr6:146334030 C/A cg05347473 chr6:146136440 FBXO30 0.49 6.44 0.37 5.75e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs34779708 0.931 rs11597392 chr10:35288575 T/C cg03585969 chr10:35415529 CREM 0.74 9.48 0.5 1.51e-18 Inflammatory bowel disease;Crohn's disease; CESC cis rs11098499 0.863 rs12498539 chr4:120468370 C/T cg24375607 chr4:120327624 NA 0.43 5.32 0.31 2.16e-7 Corneal astigmatism; CESC cis rs4843747 0.671 rs4072871 chr16:88106614 C/T cg03395651 chr16:88107091 BANP 0.46 5.36 0.31 1.82e-7 Menopause (age at onset); CESC cis rs2777491 0.957 rs316614 chr15:41746625 A/G cg02330683 chr15:41787940 ITPKA 0.47 7.04 0.4 1.64e-11 Ulcerative colitis; CESC cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg05347473 chr6:146136440 FBXO30 -0.52 -6.7 -0.38 1.24e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7845219 0.544 rs7016078 chr8:95922615 G/A cg16049864 chr8:95962084 TP53INP1 -0.5 -7.42 -0.41 1.63e-12 Type 2 diabetes; CESC cis rs7264396 0.690 rs2425175 chr20:34445563 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.36 0.41 2.25e-12 Total cholesterol levels; CESC cis rs9611565 0.694 rs202618 chr22:41822856 A/G cg06481639 chr22:41940642 POLR3H 0.64 6.41 0.37 6.73e-10 Vitiligo; CESC cis rs11792861 0.781 rs72607158 chr9:111763010 T/C cg05043794 chr9:111880884 C9orf5 -0.38 -6.16 -0.35 2.76e-9 Menarche (age at onset); CESC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg07701084 chr6:150067640 NUP43 0.46 6.42 0.37 6.12e-10 Lung cancer; CESC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg17724175 chr1:150552817 MCL1 0.45 7.34 0.41 2.6e-12 Tonsillectomy; CESC cis rs11792861 0.816 rs3818932 chr9:111664178 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 6.61 0.38 2.14e-10 Menarche (age at onset); CESC trans rs1728785 0.748 rs889560 chr16:68605784 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.93 0.44 6e-14 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10197162 chr2:61108677 REL 0.63 7.23 0.41 5.14e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27430682 chr10:65225552 JMJD1C;LOC84989 0.59 6.54 0.37 3.07e-10 Gut microbiome composition (summer); CESC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg06492744 chr11:65406254 SIPA1 0.42 5.1 0.3 6.4e-7 Blood pressure (age interaction); CESC cis rs554111 0.560 rs592060 chr1:21050958 A/G cg21184320 chr1:21044207 KIF17 -0.44 -5.12 -0.3 5.79e-7 Facial morphology (factor 17, height of vermillion upper lip); CESC cis rs9811920 0.809 rs793437 chr3:99559854 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -7.65 -0.43 3.62e-13 Axial length; CESC cis rs4689592 0.503 rs56099074 chr4:7071259 A/G cg19539972 chr4:7069911 GRPEL1 -0.71 -7.34 -0.41 2.64e-12 Monocyte percentage of white cells; CESC cis rs425277 0.958 rs7546523 chr1:2043792 G/A cg04315214 chr1:2043799 PRKCZ -0.44 -6.02 -0.35 5.69e-9 Height; CESC cis rs6087771 0.890 rs6089056 chr20:30325773 A/G cg13852791 chr20:30311386 BCL2L1 0.85 11.17 0.57 5.35e-24 Subcortical brain region volumes;Putamen volume; CESC cis rs636291 0.517 rs12565133 chr1:10544988 A/C cg07384165 chr1:10488281 NA 0.54 7.9 0.44 7.28e-14 Prostate cancer; CESC cis rs11166927 1.000 rs13256946 chr8:140805101 G/A cg16909799 chr8:140841666 TRAPPC9 0.61 8.98 0.48 5.04e-17 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs2295359 1.000 rs4655683 chr1:67611613 C/T cg03340356 chr1:67600835 NA 0.3 5.04 0.3 8.67e-7 Psoriasis; CESC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg22535103 chr8:58192502 C8orf71 -0.94 -9.38 -0.5 3.05e-18 Developmental language disorder (linguistic errors); CESC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg25036284 chr2:26402008 FAM59B -0.6 -6.91 -0.39 3.64e-11 Gut microbiome composition (summer); CESC trans rs7980799 0.682 rs10437795 chr12:33635336 C/G cg26384229 chr12:38710491 ALG10B -0.6 -8.66 -0.47 4.71e-16 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs1580019 0.961 rs1580021 chr7:32497702 T/G cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.13 0.53 1.34e-20 Cognitive ability; CESC cis rs9811920 0.638 rs793461 chr3:99615758 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs8077577 0.638 rs4386179 chr17:18134774 A/G cg16794390 chr17:18148240 FLII -0.44 -6.43 -0.37 5.97e-10 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02159896 chr18:11908181 MPPE1 -0.54 -6.11 -0.35 3.51e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10737766 chr2:98280628 ACTR1B 0.62 6.84 0.39 5.4e-11 Gut microbiome composition (summer); CESC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.55 7.4 0.41 1.84e-12 Lymphocyte counts; CESC cis rs7586879 0.639 rs13407913 chr2:25097644 A/G cg01884057 chr2:25150051 NA 0.38 7.4 0.41 1.85e-12 Body mass index; CESC trans rs11165623 0.792 rs12123543 chr1:96964549 T/C cg10631902 chr5:14652156 NA -0.5 -7.4 -0.41 1.76e-12 Hip circumference;Waist circumference; CESC cis rs76419734 0.510 rs7659526 chr4:106621643 T/C cg24545054 chr4:106630052 GSTCD;INTS12 0.74 9.22 0.49 9.47e-18 Post bronchodilator FEV1; CESC cis rs317689 0.690 rs604168 chr12:69671158 C/T cg14784868 chr12:69753453 YEATS4 0.48 5.26 0.31 3e-7 Response to diuretic therapy; CESC cis rs8092503 1.000 rs2871673 chr18:52491427 G/T cg12377874 chr18:52495404 RAB27B -0.43 -6.49 -0.37 4.11e-10 Childhood body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04233664 chr10:126848743 CTBP2 -0.45 -6.26 -0.36 1.57e-9 Fibrinogen levels; CESC cis rs367943 1.000 rs1057827 chr5:112823768 T/C cg12552261 chr5:112820674 MCC 0.63 7.96 0.44 4.96e-14 Type 2 diabetes; CESC cis rs5758659 0.519 rs133307 chr22:42396568 C/A cg04733989 chr22:42467013 NAGA 0.44 5.82 0.34 1.7e-8 Cognitive function; CESC cis rs7666738 0.677 rs13120306 chr4:99036099 A/T cg18180107 chr4:99064573 C4orf37 0.43 5.4 0.31 1.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.34 -5.41 -0.32 1.4e-7 Personality dimensions; CESC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs7937682 0.883 rs11213941 chr11:111434094 T/C cg22437258 chr11:111473054 SIK2 -0.72 -8.72 -0.47 3.05e-16 Primary sclerosing cholangitis; CESC cis rs734999 0.572 rs4310388 chr1:2507415 G/T cg18854424 chr1:2615690 NA 0.26 5.06 0.3 7.87e-7 Ulcerative colitis; CESC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg07755735 chr2:20870362 GDF7 -0.47 -7.03 -0.4 1.8e-11 Abdominal aortic aneurysm; CESC cis rs765787 0.530 rs4775836 chr15:45537664 T/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs1355223 0.752 rs896856 chr11:34676842 G/T cg11058730 chr11:34937778 PDHX;APIP -0.47 -5.99 -0.35 6.66e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6088590 1.000 rs2180276 chr20:33360785 T/A cg08999081 chr20:33150536 PIGU 0.58 8.98 0.48 5.31e-17 Coronary artery disease; CESC cis rs11792861 0.926 rs75472294 chr9:111804239 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.48 6.07 0.35 4.29e-9 Menarche (age at onset); CESC cis rs735396 0.627 rs2264778 chr12:121450354 C/A cg02403541 chr12:121454288 C12orf43 0.8 11.7 0.58 9.06e-26 N-glycan levels; CESC cis rs5758659 0.714 rs133376 chr22:42466905 C/T cg15557168 chr22:42548783 NA -0.48 -7.52 -0.42 8.34e-13 Cognitive function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00773818 chr12:52426922 NA -0.47 -6.09 -0.35 3.88e-9 Fibrinogen levels; CESC cis rs2404602 0.692 rs12913810 chr15:77166675 T/C cg26408565 chr15:76604113 ETFA -0.39 -5.68 -0.33 3.6e-8 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11176889 chr7:32997094 FKBP9 0.54 6.0 0.35 6.59e-9 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21883765 chr7:127032075 ZNF800 -0.47 -6.35 -0.36 9.36e-10 Asthma; CESC trans rs208520 1.000 rs12200490 chr6:66976084 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 9.39 0.5 2.86e-18 Exhaled nitric oxide output; CESC cis rs694739 1.000 rs11231757 chr11:64106317 C/T cg02228329 chr11:64053129 BAD;GPR137 0.68 8.74 0.47 2.74e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg25072359 chr17:41440525 NA 0.47 6.21 0.36 2.04e-9 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16458507 chr12:113376293 OAS3 0.59 6.96 0.39 2.68e-11 Gut microbiome composition (summer); CESC cis rs477692 0.673 rs7909964 chr10:131338714 T/C cg24747557 chr10:131355152 MGMT -0.39 -5.41 -0.32 1.44e-7 Response to temozolomide; CESC cis rs593982 0.920 rs72922791 chr11:65567395 G/A cg08755490 chr11:65554678 OVOL1 -1.15 -11.04 -0.56 1.5e-23 Atopic dermatitis; CESC cis rs7584330 0.554 rs111512641 chr2:238429538 G/A cg14458575 chr2:238380390 NA 0.53 5.76 0.33 2.32e-8 Prostate cancer; CESC cis rs977987 0.815 rs4887829 chr16:75488935 C/T cg03315344 chr16:75512273 CHST6 0.44 6.44 0.37 5.73e-10 Dupuytren's disease; CESC cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.41 5.83 0.34 1.59e-8 Schizophrenia; CESC cis rs4971059 0.617 rs12025371 chr1:155119327 A/T cg22049894 chr1:155113146 DPM3 0.46 5.87 0.34 1.3e-8 Breast cancer; CESC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg24250549 chr1:154909240 PMVK 0.71 10.45 0.54 1.29e-21 Prostate cancer; CESC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg13206674 chr6:150067644 NUP43 0.41 5.5 0.32 8.99e-8 Lung cancer; CESC cis rs7940866 0.804 rs10894287 chr11:130808483 C/T cg12179176 chr11:130786555 SNX19 0.62 9.65 0.51 4.39e-19 Schizophrenia; CESC cis rs2228479 1.000 rs62052180 chr16:89963289 C/G cg00800038 chr16:89945340 TCF25 -0.84 -7.29 -0.41 3.49e-12 Skin colour saturation; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02330394 chr6:10695063 C6orf52;PAK1IP1 0.46 6.02 0.35 5.66e-9 Asthma; CESC cis rs9399401 0.667 rs11155242 chr6:142691549 A/C cg04461802 chr6:142623433 GPR126 0.36 5.31 0.31 2.29e-7 Chronic obstructive pulmonary disease; CESC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9325144 0.581 rs6582564 chr12:38671282 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.6 -0.51 6.3e-19 Morning vs. evening chronotype; CESC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg06456125 chr7:65229604 NA -0.39 -5.09 -0.3 6.82e-7 Aortic root size; CESC cis rs1878931 0.507 rs1218762 chr16:3405986 G/A cg02880119 chr16:3481970 NA 0.39 5.08 0.3 7.19e-7 Body mass index (adult); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01261044 chr14:35451962 SRP54 0.47 6.33 0.36 1.02e-9 Gut microbiota (bacterial taxa); CESC cis rs9911578 0.692 rs412000 chr17:56709058 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.42 5.67 0.33 3.82e-8 Intelligence (multi-trait analysis); CESC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg06028605 chr16:24865363 SLC5A11 0.55 8.13 0.45 1.62e-14 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs116095464 0.558 rs9654452 chr5:299561 C/T cg22496380 chr5:211416 CCDC127 -0.75 -8.55 -0.46 1.03e-15 Breast cancer; CESC cis rs10949834 0.715 rs710968 chr7:73497728 A/G cg07137043 chr7:73588983 EIF4H 0.65 7.19 0.4 6.54e-12 Verbal memory performance (residualized delayed recall change); CESC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Tonsillectomy; CESC cis rs7666738 0.546 rs7679681 chr4:98882221 A/G cg17366294 chr4:99064904 C4orf37 0.52 6.66 0.38 1.56e-10 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg23161317 chr6:28129485 ZNF389 0.5 6.31 0.36 1.19e-9 Depression; CESC cis rs9815354 0.868 rs1716653 chr3:41975598 C/A cg03022575 chr3:42003672 ULK4 -0.46 -5.37 -0.31 1.74e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg21285383 chr16:89894308 SPIRE2 0.32 5.85 0.34 1.46e-8 Vitiligo; CESC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.58 0.37 2.5e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00837765 chr8:74884459 TCEB1 0.59 6.37 0.36 8.23e-10 Gut microbiome composition (summer); CESC cis rs7605827 0.930 rs10184585 chr2:15683091 G/A cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs1707322 0.929 rs785513 chr1:46538320 T/C cg03146154 chr1:46216737 IPP -0.7 -9.01 -0.48 4.28e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg03452623 chr4:187889614 NA 0.79 12.65 0.61 5.08e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs8114671 0.839 rs6142290 chr20:33654672 A/C cg06115741 chr20:33292138 TP53INP2 -0.44 -5.31 -0.31 2.27e-7 Height; CESC cis rs1355223 0.816 rs2136506 chr11:34748260 T/C cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.13 -0.35 3.23e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs4268898 0.662 rs9917315 chr2:24431501 C/A cg06627628 chr2:24431161 ITSN2 -1.02 -11.2 -0.57 4.2e-24 Asthma; CESC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg16325326 chr1:53192061 ZYG11B -0.89 -15.32 -0.69 2.26e-38 Monocyte count; CESC cis rs9297145 0.585 rs10953281 chr7:98772131 C/T cg05967295 chr7:98741636 SMURF1 -0.6 -8.26 -0.45 7.19e-15 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs57506017 0.585 rs3800841 chr7:12272568 A/T cg23422036 chr7:12250390 TMEM106B 0.39 5.17 0.3 4.57e-7 Neuroticism; CESC cis rs897080 0.515 rs1065784 chr2:44660777 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.07 0.3 7.49e-7 Height; CESC cis rs10461617 0.535 rs7709874 chr5:56047451 C/T cg24549020 chr5:56110836 MAP3K1 0.43 5.1 0.3 6.47e-7 Type 2 diabetes; CESC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg22920501 chr2:26401640 FAM59B 0.91 9.92 0.52 6.43e-20 Gut microbiome composition (summer); CESC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.38 5.04 0.3 8.73e-7 Menopause (age at onset); CESC cis rs7786808 0.615 rs4909209 chr7:158194329 C/T cg09998033 chr7:158218633 PTPRN2 -0.38 -5.54 -0.32 7.25e-8 Obesity-related traits; CESC cis rs425277 1.000 rs425277 chr1:2069172 C/T cg16545954 chr1:2118288 C1orf86 0.33 5.58 0.32 5.83e-8 Height; CESC cis rs8060686 0.641 rs7204974 chr16:68033539 G/A cg26727032 chr16:67993705 SLC12A4 -0.55 -7.02 -0.4 1.81e-11 HDL cholesterol;Metabolic syndrome; CESC cis rs988913 0.723 rs7761785 chr6:55002037 C/T cg03513858 chr6:54763001 FAM83B 0.33 5.05 0.3 8.26e-7 Menarche (age at onset); CESC cis rs1005277 0.579 rs1780122 chr10:38529509 C/A cg25517755 chr10:38738941 LOC399744 -0.49 -6.39 -0.37 7.49e-10 Extrinsic epigenetic age acceleration; CESC cis rs754466 0.580 rs10762763 chr10:79560803 C/G cg17075019 chr10:79541650 NA -0.78 -12.48 -0.61 2.06e-28 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2072732 0.821 rs12034766 chr1:2944038 A/G cg15211996 chr1:2936768 ACTRT2 0.35 5.74 0.33 2.65e-8 Plateletcrit; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17214737 chr10:75757811 VCL 0.52 7.37 0.41 2.22e-12 Systemic lupus erythematosus; CESC cis rs1670533 1.000 rs641987 chr4:1077542 C/T cg27284194 chr4:1044797 NA 0.47 5.91 0.34 1.04e-8 Recombination rate (females); CESC cis rs1707322 0.647 rs6686944 chr1:46156308 G/T cg05343316 chr1:45956843 TESK2 0.5 6.14 0.35 3e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2456568 0.803 rs10765642 chr11:93640355 C/T cg26875233 chr11:93583750 C11orf90 0.3 5.47 0.32 1.03e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs523522 0.571 rs11065120 chr12:120875456 C/T cg27279351 chr12:120934652 DYNLL1 0.5 5.55 0.32 7.1e-8 High light scatter reticulocyte count; CESC cis rs2295499 0.673 rs73189408 chr4:2705644 T/A cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.2 -0.3 3.91e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs6693567 0.565 rs6684939 chr1:150440563 G/A cg09579323 chr1:150459698 TARS2 -0.45 -5.78 -0.33 2.11e-8 Migraine; CESC cis rs12887734 0.566 rs3742366 chr14:104198351 T/C cg01849466 chr14:104193079 ZFYVE21 -0.45 -5.73 -0.33 2.71e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00472393 chr6:97730957 C6orf167;MIR548H3 0.53 6.08 0.35 4.29e-9 Gut microbiome composition (summer); CESC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg18337363 chr3:52569053 NT5DC2 0.35 6.19 0.36 2.31e-9 Bipolar disorder; CESC cis rs9902453 0.933 rs7216494 chr17:28502651 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 7.48 0.42 1.11e-12 Coffee consumption (cups per day); CESC cis rs3796352 1.000 rs11710292 chr3:53117798 T/C cg15956490 chr3:53032818 SFMBT1 0.63 5.23 0.31 3.38e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs2274273 0.868 rs6573007 chr14:55625938 T/G cg04306507 chr14:55594613 LGALS3 0.29 5.82 0.34 1.71e-8 Protein biomarker; CESC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg01341218 chr17:43662625 NA 0.89 11.19 0.57 4.64e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs548181 0.611 rs609200 chr11:125383808 G/A cg03464685 chr11:125439445 EI24 -1.4 -11.25 -0.57 2.83e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg00310523 chr12:86230176 RASSF9 0.37 5.56 0.32 6.42e-8 Major depressive disorder; CESC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg05564831 chr3:52568323 NT5DC2 0.39 6.07 0.35 4.5e-9 Electroencephalogram traits; CESC cis rs7949030 0.688 rs2849031 chr11:62365665 G/A cg22862634 chr11:62369728 EML3;MTA2 -0.54 -7.45 -0.42 1.32e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs13082711 0.513 rs7612102 chr3:27372826 A/G cg02860705 chr3:27208620 NA -0.62 -7.34 -0.41 2.62e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs9902453 0.904 rs4547389 chr17:28364768 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.69 -0.47 3.78e-16 Coffee consumption (cups per day); CESC cis rs7100689 0.784 rs4258322 chr10:82184770 T/C cg00277334 chr10:82204260 NA -0.62 -7.51 -0.42 8.99e-13 Post bronchodilator FEV1; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg18816107 chr1:151227233 PSMD4 0.47 6.09 0.35 3.9e-9 Breast cancer;Type 2 diabetes; CESC cis rs11625487 0.609 rs74063385 chr14:77966859 C/T cg20045696 chr14:77926864 AHSA1 -0.7 -5.42 -0.32 1.33e-7 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs116095464 0.558 rs7356561 chr5:284381 G/C cg10591111 chr5:226296 SDHA -0.53 -6.43 -0.37 6.03e-10 Breast cancer; CESC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs644799 1.000 rs3748256 chr11:95521953 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.73 0.67 2.69e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg12311346 chr5:56204834 C5orf35 -0.72 -8.77 -0.47 2.14e-16 Initial pursuit acceleration; CESC cis rs7520050 0.966 rs10789481 chr1:46383583 C/G cg03146154 chr1:46216737 IPP -0.47 -6.08 -0.35 4.13e-9 Red blood cell count;Reticulocyte count; CESC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg16743903 chr16:89593216 SPG7 -0.44 -5.73 -0.33 2.74e-8 Multiple myeloma (IgH translocation); CESC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12900413 0.687 rs12908468 chr15:90304236 T/G cg24249390 chr15:90295951 MESP1 -0.4 -5.61 -0.33 5.2e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg02427764 chr11:65769310 BANF1;EIF1AD -0.43 -5.06 -0.3 8e-7 Breast cancer; CESC cis rs6582630 0.519 rs1851130 chr12:38507819 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.32 0.54 3.31e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg24308560 chr3:49941425 MST1R 0.56 8.0 0.44 4.01e-14 Body mass index; CESC cis rs7527798 0.592 rs6667238 chr1:207822856 G/A cg21110645 chr1:207815933 NA -0.33 -5.94 -0.34 9.12e-9 Erythrocyte sedimentation rate; CESC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg00166722 chr3:10149974 C3orf24 0.52 6.61 0.38 2.15e-10 Alzheimer's disease; CESC cis rs919433 0.929 rs1366836 chr2:198172148 T/G cg03934865 chr2:198174659 NA -0.48 -7.4 -0.41 1.83e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs11785400 0.963 rs4579507 chr8:143733663 C/G cg10596483 chr8:143751796 JRK 0.43 5.6 0.33 5.24e-8 Schizophrenia; CESC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg26335602 chr6:28129616 ZNF389 0.52 6.84 0.39 5.54e-11 Depression; CESC trans rs8073060 0.516 rs2376177 chr17:33938089 T/G cg19694781 chr19:47549865 TMEM160 -0.71 -6.99 -0.39 2.2e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg22029157 chr1:209979665 IRF6 0.69 10.12 0.53 1.49e-20 Cleft lip with or without cleft palate; CESC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.57 -0.37 2.64e-10 Total body bone mineral density; CESC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.31 0.54 3.45e-21 Prudent dietary pattern; CESC cis rs9611565 0.694 rs202622 chr22:41825342 T/G cg17376030 chr22:41985996 PMM1 -0.76 -8.1 -0.45 2.03e-14 Vitiligo; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26037239 chr1:153643678 ILF2 -0.43 -6.13 -0.35 3.09e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs459571 0.959 rs410876 chr9:136893867 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.58 -7.5 -0.42 9.62e-13 Platelet distribution width; CESC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg04553112 chr3:125709451 NA -0.51 -5.57 -0.32 6.4e-8 Blood pressure (smoking interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25927753 chr2:74153795 DGUOK 0.49 6.66 0.38 1.53e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11039798 1.000 rs6485908 chr11:48652198 C/T cg15704280 chr7:45808275 SEPT13 -0.64 -6.34 -0.36 9.86e-10 Axial length; CESC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg19592336 chr6:28129416 ZNF389 -0.56 -7.47 -0.42 1.2e-12 Depression; CESC cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg02297831 chr4:17616191 MED28 -0.51 -6.15 -0.35 2.86e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.3e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 7.89 0.44 7.81e-14 Platelet count; CESC cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.53 0.46 1.15e-15 Colonoscopy-negative controls vs population controls; CESC cis rs13418410 0.539 rs11695597 chr2:33840024 A/G cg04131969 chr2:33951647 MYADML 0.55 6.79 0.39 7.25e-11 Non-response to antidepressants and depression; CESC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 8.93 0.48 7.4e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1018836 0.739 rs4734247 chr8:91569144 A/G cg16814680 chr8:91681699 NA -0.6 -8.37 -0.46 3.34e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs3820068 0.581 rs16851848 chr1:15927698 G/A cg17385448 chr1:15911702 AGMAT 0.41 6.69 0.38 1.33e-10 Systolic blood pressure; CESC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 8.76 0.47 2.32e-16 Personality dimensions; CESC cis rs8180040 1.000 rs4858888 chr3:47405305 C/T cg27129171 chr3:47204927 SETD2 -0.65 -9.61 -0.51 5.86e-19 Colorectal cancer; CESC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg24531977 chr5:56204891 C5orf35 -0.92 -11.16 -0.57 5.79e-24 Initial pursuit acceleration; CESC cis rs55728055 0.661 rs10428007 chr22:31646653 C/T cg01338084 chr22:32026380 PISD 0.76 5.93 0.34 9.43e-9 Age-related hearing impairment; CESC trans rs3942852 0.955 rs1532754 chr11:48115279 A/T cg15704280 chr7:45808275 SEPT13 -0.62 -6.89 -0.39 4.06e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs7605827 0.930 rs6723148 chr2:15592019 G/T cg19274914 chr2:15703543 NA 0.32 5.6 0.33 5.4e-8 Educational attainment (years of education); CESC cis rs57506017 0.540 rs4721061 chr7:12267559 G/C cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.58e-7 Neuroticism; CESC cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg15605315 chr1:45957053 TESK2 0.5 6.63 0.38 1.83e-10 High light scatter reticulocyte count; CESC cis rs67460515 0.563 rs11717272 chr3:160810355 A/G cg03342759 chr3:160939853 NMD3 -0.51 -6.38 -0.37 7.65e-10 Parkinson's disease; CESC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg07636037 chr3:49044803 WDR6 0.89 15.27 0.68 3.33e-38 Menarche (age at onset); CESC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg06697600 chr4:7070879 GRPEL1 -0.57 -8.25 -0.45 7.58e-15 Monocyte percentage of white cells; CESC cis rs9303401 0.659 rs7223708 chr17:56896398 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.68 0.61 4.11e-29 Cognitive test performance; CESC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg23803603 chr1:2058230 PRKCZ -0.37 -6.62 -0.38 1.94e-10 Height; CESC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.34 -0.36 9.62e-10 Bipolar disorder; CESC cis rs4629180 0.920 rs4851458 chr2:102108794 T/C cg04415270 chr2:102091202 RFX8 -0.44 -7.23 -0.41 5.31e-12 Chronic rhinosinusitis with nasal polyps; CESC cis rs477692 0.604 rs1008982 chr10:131445731 T/C cg05714579 chr10:131428358 MGMT -0.61 -8.49 -0.46 1.49e-15 Response to temozolomide; CESC cis rs7953249 0.618 rs2650000 chr12:121388962 G/T cg25281562 chr12:121454272 C12orf43 0.44 5.67 0.33 3.82e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs796364 0.806 rs11679676 chr2:201040981 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.8 -6.17 -0.35 2.52e-9 Schizophrenia; CESC cis rs11122272 0.670 rs2474632 chr1:231484361 C/T cg06096015 chr1:231504339 EGLN1 0.44 6.46 0.37 5.12e-10 Hemoglobin concentration; CESC cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg08847533 chr14:75593920 NEK9 -1.0 -18.49 -0.75 1.41e-49 Height; CESC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg03351412 chr1:154909251 PMVK 0.66 8.89 0.48 9.97e-17 Prostate cancer; CESC cis rs12449000 1 rs12449000 chr16:89872970 T/C cg07648498 chr16:89883185 FANCA 0.55 7.01 0.4 1.94e-11 Schizophrenia; CESC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg26354017 chr1:205819088 PM20D1 0.84 13.62 0.64 2.19e-32 Menarche (age at onset); CESC cis rs6662572 0.737 rs2067635 chr1:46537946 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 5.3 0.31 2.43e-7 Blood protein levels; CESC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg13866156 chr1:1669148 SLC35E2 -0.51 -6.75 -0.38 9.36e-11 Body mass index; CESC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg08027265 chr7:2291960 NA -0.38 -5.71 -0.33 3.01e-8 Schizophrenia; CESC cis rs10788972 0.933 rs4492560 chr1:54568488 G/A cg25741118 chr1:54482237 LDLRAD1 -0.23 -5.45 -0.32 1.13e-7 Parkinson disease and lewy body pathology; CESC cis rs78456975 1.000 rs72776298 chr2:1570163 C/G cg26248373 chr2:1572462 NA -0.56 -5.21 -0.31 3.72e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs6987853 0.787 rs2974300 chr8:42440532 C/T cg09913449 chr8:42400586 C8orf40 0.46 7.8 0.43 1.45e-13 Mean corpuscular hemoglobin concentration; CESC cis rs10791323 0.569 rs11533204 chr11:133743644 A/G cg15485101 chr11:133734466 NA 0.3 5.22 0.31 3.6e-7 Childhood ear infection; CESC cis rs1865760 0.532 rs2006736 chr6:26086017 C/T cg17691542 chr6:26056736 HIST1H1C 0.42 5.57 0.32 6.13e-8 Height; CESC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg11663144 chr21:46675770 NA -0.63 -10.02 -0.52 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6772849 0.930 rs9813197 chr3:128369104 G/A cg16766828 chr3:128327626 NA -0.31 -5.08 -0.3 7.13e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs1692580 0.840 rs262679 chr1:2169792 C/T cg24578937 chr1:2090814 PRKCZ 0.33 5.34 0.31 2.05e-7 Coronary artery disease; CESC cis rs7786808 0.741 rs11765319 chr7:158226790 A/G cg01191920 chr7:158217561 PTPRN2 -0.43 -7.99 -0.44 4.03e-14 Obesity-related traits; CESC cis rs12142240 0.698 rs6679898 chr1:46820589 A/C cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs8072100 0.967 rs9894905 chr17:45485982 C/T cg08085267 chr17:45401833 C17orf57 -0.53 -7.26 -0.41 4.38e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs6500602 0.701 rs4785971 chr16:4577090 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.38 5.25 0.31 3.11e-7 Schizophrenia; CESC cis rs854765 0.583 rs4925129 chr17:17807186 A/G cg16928487 chr17:17741425 SREBF1 -0.59 -9.94 -0.52 5.26e-20 Total body bone mineral density; CESC cis rs704 0.585 rs3093680 chr17:26664806 T/C cg10342447 chr17:26645325 TMEM97 -0.45 -6.29 -0.36 1.29e-9 Osteoprotegerin levels; CESC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg18876405 chr7:65276391 NA 0.51 6.86 0.39 4.82e-11 Aortic root size; CESC cis rs748404 0.578 rs552701 chr15:43613810 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.75 0.47 2.5e-16 Lung cancer; CESC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg24060327 chr5:131705240 SLC22A5 0.73 9.83 0.52 1.18e-19 Breast cancer; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg13610055 chr14:68676965 RAD51L1 0.4 6.13 0.35 3.21e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1348850 0.958 rs4243390 chr2:178468008 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 8.8 0.48 1.79e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg06212747 chr3:49208901 KLHDC8B -0.68 -8.19 -0.45 1.11e-14 Parkinson's disease; CESC trans rs7944735 0.517 rs1827503 chr11:48225115 G/T cg15704280 chr7:45808275 SEPT13 0.7 6.41 0.37 6.46e-10 Intraocular pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24274347 chr12:132497611 EP400 -0.56 -6.17 -0.35 2.54e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.591 rs8135363 chr22:46651713 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.18 0.45 1.16e-14 LDL cholesterol;Cholesterol, total; CESC cis rs7178572 0.568 rs12908262 chr15:77493256 G/A cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC cis rs9308433 0.529 rs11120298 chr1:214500620 A/G cg06198575 chr1:214491504 SMYD2 0.5 6.1 0.35 3.74e-9 IgG glycosylation; CESC cis rs4604732 0.536 rs78019731 chr1:247626430 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs35160687 0.623 rs11127019 chr2:86467618 G/A cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.23 -0.31 3.42e-7 Night sleep phenotypes; CESC cis rs2721195 0.614 rs12719778 chr8:145879883 T/C cg11211951 chr8:145729740 GPT 0.43 7.24 0.41 4.81e-12 Age at first birth; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13410609 chr19:50291885 AP2A1 0.5 7.15 0.4 8.55e-12 Fibrinogen levels; CESC cis rs7208859 0.623 rs9900144 chr17:29208389 T/C cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1707322 1.000 rs11211217 chr1:46348229 C/G cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.77 0.33 2.25e-8 Menopause (age at onset); CESC cis rs9467711 0.606 rs68072215 chr6:26377927 T/C cg12826209 chr6:26865740 GUSBL1 0.63 5.11 0.3 6.25e-7 Autism spectrum disorder or schizophrenia; CESC cis rs2625529 0.617 rs16956369 chr15:72182813 C/T cg16672083 chr15:72433130 SENP8 0.35 5.17 0.3 4.62e-7 Red blood cell count; CESC cis rs1670533 0.932 rs9992925 chr4:1050909 A/T cg27284194 chr4:1044797 NA 0.45 5.54 0.32 7.32e-8 Recombination rate (females); CESC cis rs6460942 0.659 rs17192500 chr7:12545379 A/G cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg24675658 chr1:53192096 ZYG11B -0.5 -6.2 -0.36 2.16e-9 Monocyte count; CESC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg14393609 chr7:65229607 NA 0.45 6.11 0.35 3.6e-9 Aortic root size; CESC cis rs9926296 0.572 rs2079671 chr16:89884981 T/C cg04287289 chr16:89883240 FANCA 0.65 9.05 0.49 3.23e-17 Vitiligo; CESC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg06453172 chr10:134556979 INPP5A -0.42 -5.32 -0.31 2.19e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06296021 chr5:133702588 CDKL3 0.52 6.65 0.38 1.67e-10 Gut microbiota (bacterial taxa); CESC cis rs9611565 0.765 rs132909 chr22:41802031 G/A cg17376030 chr22:41985996 PMM1 -0.59 -6.24 -0.36 1.69e-9 Vitiligo; CESC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg19346786 chr7:2764209 NA -0.5 -7.16 -0.4 8.12e-12 Height; CESC cis rs72772090 0.539 rs11738810 chr5:96119055 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.21 -0.3 3.74e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg10541313 chr22:46663664 TTC38 0.61 5.23 0.31 3.38e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7193541 0.684 rs4888265 chr16:74683737 T/C cg05580060 chr16:74700937 RFWD3 -0.49 -6.45 -0.37 5.33e-10 Multiple myeloma; CESC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg17143192 chr8:8559678 CLDN23 0.71 8.17 0.45 1.27e-14 Obesity-related traits; CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg06877462 chr1:205807181 PM20D1 0.46 7.03 0.4 1.76e-11 Menarche (age at onset); CESC cis rs2777491 0.574 rs316616 chr15:41746276 G/A cg02330683 chr15:41787940 ITPKA 0.42 5.07 0.3 7.48e-7 Ulcerative colitis; CESC cis rs7116495 1.000 rs585228 chr11:71773289 G/C cg10381502 chr11:71823885 C11orf51 -0.67 -5.66 -0.33 3.92e-8 Severe influenza A (H1N1) infection; CESC cis rs977987 0.843 rs4888372 chr16:75313485 G/A cg03315344 chr16:75512273 CHST6 0.38 5.4 0.31 1.5e-7 Dupuytren's disease; CESC cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg11764359 chr7:65958608 NA -0.82 -9.95 -0.52 4.98e-20 Aortic root size; CESC cis rs9911578 1.000 rs12453459 chr17:56624291 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.53 -0.32 7.63e-8 Intelligence (multi-trait analysis); CESC cis rs741677 0.663 rs441438 chr17:491006 C/T cg15660573 chr17:549704 VPS53 0.43 5.62 0.33 4.75e-8 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); CESC cis rs2011503 1.000 rs76790018 chr19:19652157 G/A cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs12477438 0.765 rs7571390 chr2:99626593 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -8.99 -0.48 4.8e-17 Chronic sinus infection; CESC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.66 0.55 2.52e-22 Platelet count; CESC cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg10523679 chr1:76189770 ACADM 0.76 9.99 0.52 3.63e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4253772 0.591 rs9627324 chr22:46656511 A/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.48 5.08 0.3 7.09e-7 LDL cholesterol;Cholesterol, total; CESC cis rs1878931 0.668 rs2074366 chr16:3439676 G/A cg22508957 chr16:3507546 NAT15 -0.42 -6.04 -0.35 5.09e-9 Body mass index (adult); CESC cis rs6582630 0.502 rs11495393 chr12:38341194 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.63 0.33 4.49e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg12463550 chr7:65579703 CRCP 0.49 6.35 0.36 9.51e-10 Aortic root size; CESC cis rs2708240 0.577 rs13235812 chr7:147556653 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 0.3 5.04 0.3 8.82e-7 QT interval (drug interaction); CESC cis rs9291683 0.546 rs7442336 chr4:10045783 G/A cg02734326 chr4:10020555 SLC2A9 0.45 6.18 0.36 2.35e-9 Bone mineral density; CESC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg12463550 chr7:65579703 CRCP -0.51 -6.54 -0.37 3.18e-10 Aortic root size; CESC cis rs17036350 1 rs17036350 chr1:11171226 C/T cg18435880 chr1:11160013 EXOSC10 0.93 6.8 0.39 7.04e-11 Corneal curvature; CESC trans rs10506458 0.915 rs1463821 chr12:63402875 C/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.32 17.07 0.72 1.42e-44 Hemostatic factors and hematological phenotypes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14005384 chr15:89877925 POLG -0.46 -6.16 -0.35 2.67e-9 Fibrinogen levels; CESC cis rs2281558 0.833 rs55792313 chr20:25521255 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.55 7.61 0.42 4.83e-13 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg23982607 chr1:1823379 GNB1 -0.76 -12.02 -0.59 7.68e-27 Body mass index; CESC cis rs12410462 0.901 rs79626242 chr1:227650385 A/G cg23173402 chr1:227635558 NA 0.55 5.41 0.32 1.41e-7 Major depressive disorder; CESC cis rs9303401 0.614 rs2240719 chr17:56582477 G/C cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.43 0.61 2.87e-28 Cognitive test performance; CESC cis rs7223966 1.000 rs2854223 chr17:61939014 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.9 0.39 3.94e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7824557 0.564 rs2736302 chr8:11236419 T/C cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.52e-14 Retinal vascular caliber; CESC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -7.54 -0.42 7.38e-13 Tonsillectomy; CESC cis rs9486719 1.000 rs2142652 chr6:96868504 A/C cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs854765 0.547 rs2955383 chr17:17941364 A/G cg04398451 chr17:18023971 MYO15A -0.71 -10.43 -0.54 1.44e-21 Total body bone mineral density; CESC cis rs589448 0.902 rs315124 chr12:69771727 G/A cg22834771 chr12:69754056 YEATS4 -0.57 -7.68 -0.43 3.15e-13 Cerebrospinal fluid biomarker levels; CESC cis rs4908760 0.811 rs301802 chr1:8497307 A/T cg00120948 chr1:8484417 RERE -0.38 -5.88 -0.34 1.21e-8 Vitiligo; CESC cis rs7089973 0.604 rs7920216 chr10:116611794 G/A cg03647239 chr10:116582469 FAM160B1 0.43 5.31 0.31 2.38e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg17376030 chr22:41985996 PMM1 -0.59 -6.55 -0.37 2.91e-10 Vitiligo; CESC cis rs1843834 0.539 rs6749402 chr2:225443901 T/G cg12698349 chr2:225449008 CUL3 0.62 8.74 0.47 2.73e-16 IgE levels in asthmatics (D.p. specific); CESC cis rs7301826 0.651 rs12228959 chr12:131296068 T/G cg11011512 chr12:131303247 STX2 0.47 5.84 0.34 1.52e-8 Plasma plasminogen activator levels; CESC cis rs9479482 0.967 rs9479478 chr6:150354608 T/G cg03788504 chr6:150331562 NA -0.3 -5.84 -0.34 1.52e-8 Alopecia areata; CESC cis rs1707322 0.686 rs61784833 chr1:46233772 T/C cg06784218 chr1:46089804 CCDC17 0.41 7.19 0.4 6.5e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7091068 0.566 rs7082701 chr10:95501042 G/T cg20715218 chr10:95462985 C10orf4 0.57 5.28 0.31 2.64e-7 Urinary tract infection frequency; CESC cis rs3768617 0.510 rs2296290 chr1:183079412 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 14.14 0.66 3.44e-34 Fuchs's corneal dystrophy; CESC cis rs910316 0.763 rs175042 chr14:75470833 A/T cg11812906 chr14:75593930 NEK9 -0.8 -12.71 -0.62 3.25e-29 Height; CESC cis rs11190604 1.000 rs11190569 chr10:102227409 C/T cg07080220 chr10:102295463 HIF1AN 0.59 6.05 0.35 4.87e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs12472274 0.941 rs2880131 chr2:239089151 A/C cg17459225 chr2:239074497 NA 0.61 9.0 0.48 4.41e-17 Phospholipid levels (plasma); CESC cis rs3087591 0.922 rs2953013 chr17:29496343 A/C cg24425628 chr17:29625626 OMG;NF1 -0.45 -5.3 -0.31 2.42e-7 Hip circumference; CESC trans rs116095464 0.558 rs10057492 chr5:239503 T/C cg00938859 chr5:1591904 SDHAP3 0.64 6.99 0.39 2.27e-11 Breast cancer; CESC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg02462569 chr6:150064036 NUP43 -0.38 -5.42 -0.32 1.32e-7 Lung cancer; CESC trans rs10435719 0.610 rs80269926 chr8:11790527 T/C cg15556689 chr8:8085844 FLJ10661 0.53 6.51 0.37 3.7e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg03433033 chr1:76189801 ACADM 0.76 10.66 0.55 2.64e-22 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg10523679 chr1:76189770 ACADM 0.66 7.42 0.41 1.6e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2559856 1.000 rs2559860 chr12:102087636 C/T cg12213457 chr12:102090980 CHPT1 -0.34 -5.09 -0.3 6.71e-7 Blood protein levels; CESC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg25072359 chr17:41440525 NA 0.46 6.14 0.35 2.97e-9 Menopause (age at onset); CESC cis rs989128 0.517 rs1809284 chr17:48632310 A/G cg24438145 chr17:48624694 SPATA20 0.44 5.15 0.3 5e-7 Type 2 diabetes; CESC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.16e-17 Prudent dietary pattern; CESC cis rs317689 0.819 rs317664 chr12:69704747 C/A cg14784868 chr12:69753453 YEATS4 0.49 5.17 0.3 4.66e-7 Response to diuretic therapy; CESC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.81 0.34 1.8e-8 Intelligence (multi-trait analysis); CESC cis rs684232 0.602 rs379998 chr17:556884 A/G cg15660573 chr17:549704 VPS53 -0.8 -11.75 -0.59 6.18e-26 Prostate cancer; CESC cis rs17376456 0.825 rs28705226 chr5:93233135 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.64 5.54 0.32 7.12e-8 Diabetic retinopathy; CESC cis rs10791097 0.694 rs61910787 chr11:130744473 G/A cg12179176 chr11:130786555 SNX19 0.64 9.94 0.52 5.35e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6558174 0.965 rs2404655 chr8:22490209 T/C cg03733263 chr8:22462867 KIAA1967 0.46 6.32 0.36 1.08e-9 Breast cancer; CESC cis rs9549367 0.577 rs3024718 chr13:113813853 C/T cg18105134 chr13:113819100 PROZ 0.71 8.76 0.47 2.32e-16 Platelet distribution width; CESC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.53 0.46 1.13e-15 Electroencephalogram traits; CESC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.42e-16 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg18252515 chr7:66147081 NA 0.43 5.73 0.33 2.67e-8 Aortic root size; CESC cis rs916888 0.821 rs199504 chr17:44861003 C/T cg01570182 chr17:44337453 NA -0.9 -10.86 -0.56 5.67e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg16278512 chr7:12443529 VWDE -0.45 -5.13 -0.3 5.62e-7 Coronary artery disease; CESC cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg26597838 chr10:835615 NA 1.18 11.37 0.57 1.12e-24 Eosinophil percentage of granulocytes; CESC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg02038168 chr22:39784481 NA -0.63 -7.27 -0.41 4.03e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs12476592 0.602 rs1446564 chr2:63731682 A/G cg17519650 chr2:63277830 OTX1 -0.47 -5.4 -0.31 1.46e-7 Childhood ear infection; CESC cis rs1030877 0.960 rs3792049 chr2:105901908 A/C cg02079111 chr2:105885981 TGFBRAP1 -0.67 -10.47 -0.54 1.06e-21 Obesity-related traits; CESC cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg20503657 chr10:835505 NA 0.82 8.47 0.46 1.66e-15 Eosinophil percentage of granulocytes; CESC cis rs7647973 0.626 rs2131108 chr3:49665390 C/T cg03060546 chr3:49711283 APEH 0.63 7.71 0.43 2.5e-13 Menarche (age at onset); CESC cis rs992157 0.560 rs6738394 chr2:219110625 G/A cg00012203 chr2:219082015 ARPC2 -0.76 -10.06 -0.53 2.22e-20 Colorectal cancer; CESC trans rs11098499 1.000 rs11098500 chr4:120219239 T/A cg25214090 chr10:38739885 LOC399744 0.68 9.36 0.5 3.61e-18 Corneal astigmatism; CESC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg02187348 chr16:89574699 SPG7 0.63 8.78 0.47 2.04e-16 Multiple myeloma (IgH translocation); CESC cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.05 0.3 8.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg20573242 chr4:122745356 CCNA2 0.53 6.59 0.38 2.34e-10 Type 2 diabetes; CESC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg12311346 chr5:56204834 C5orf35 0.65 8.62 0.47 6.03e-16 Initial pursuit acceleration; CESC cis rs2204008 0.682 rs2320517 chr12:38259239 A/T cg26384229 chr12:38710491 ALG10B 0.72 10.26 0.53 5.3e-21 Bladder cancer; CESC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.15 0.4 8.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs11514810 1.000 rs11514810 chr7:1428476 C/T cg24899294 chr7:1481343 MICALL2 -0.59 -5.2 -0.3 3.9e-7 Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder; CESC cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg21573476 chr21:45109991 RRP1B -0.57 -8.14 -0.45 1.52e-14 Mean corpuscular volume; CESC cis rs7914558 0.966 rs10883817 chr10:104755431 C/T cg04362960 chr10:104952993 NT5C2 0.45 5.97 0.34 7.49e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12477438 0.834 rs11903311 chr2:99701807 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.07 -0.53 2.12e-20 Chronic sinus infection; CESC cis rs3204270 0.714 rs7503307 chr17:79674929 C/G cg26965718 chr17:79658957 HGS -0.69 -5.21 -0.3 3.74e-7 Dental caries; CESC trans rs1994135 0.654 rs1384591 chr12:33734170 T/C cg26384229 chr12:38710491 ALG10B 0.46 6.61 0.38 2.09e-10 Resting heart rate; CESC cis rs889312 0.961 rs961847 chr5:56041064 C/T cg14703610 chr5:56206110 C5orf35 0.4 5.05 0.3 8.38e-7 Breast cancer;Breast cancer (early onset); CESC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg18876405 chr7:65276391 NA 0.49 6.3 0.36 1.24e-9 Calcium levels; CESC cis rs7267979 0.932 rs433352 chr20:25467992 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.77e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1215050 0.904 rs165246 chr4:98688541 C/T cg05340658 chr4:99064831 C4orf37 0.43 5.04 0.3 8.73e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs644799 0.965 rs2950522 chr11:95524719 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.75 0.38 9.4e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs739401 0.611 rs572373 chr11:3055361 T/C cg08508325 chr11:3079039 CARS -0.55 -10.86 -0.55 5.83e-23 Longevity; CESC cis rs2279817 0.908 rs12137775 chr1:18018927 G/T cg21791023 chr1:18019539 ARHGEF10L 0.57 7.81 0.43 1.38e-13 Neuroticism; CESC cis rs2996428 0.561 rs16824192 chr1:3748605 G/A cg13057898 chr1:3703894 LRRC47 0.35 5.21 0.3 3.84e-7 Red cell distribution width; CESC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg04944784 chr2:26401820 FAM59B 0.73 8.38 0.46 3.22e-15 Gut microbiome composition (summer); CESC cis rs12995849 0.714 rs11124064 chr2:106458891 A/G cg16077055 chr2:106428750 NCK2 0.4 6.17 0.35 2.58e-9 Addiction; CESC trans rs208520 0.690 rs1318604 chr6:66825278 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -12.92 -0.62 5.99e-30 Exhaled nitric oxide output; CESC cis rs3749237 0.615 rs11130202 chr3:49566715 C/T cg07636037 chr3:49044803 WDR6 0.6 8.82 0.48 1.6e-16 Resting heart rate; CESC cis rs5498 0.809 rs2228615 chr19:10403368 G/A cg22910295 chr19:10403862 ICAM5 0.43 6.06 0.35 4.55e-9 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.75 11.08 0.56 1.04e-23 Hip circumference adjusted for BMI; CESC cis rs10754283 0.967 rs7523518 chr1:90110010 G/A cg21401794 chr1:90099060 LRRC8C 0.68 9.24 0.49 8.33e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9303401 0.659 rs17822837 chr17:56737838 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.95 10.87 0.56 5.36e-23 Cognitive test performance; CESC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.71e-16 Initial pursuit acceleration; CESC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg06873352 chr17:61820015 STRADA 0.74 13.26 0.63 3.95e-31 Prudent dietary pattern; CESC cis rs3820928 1.000 rs9288617 chr2:227762815 G/C cg05526886 chr2:227700861 RHBDD1 -0.42 -5.5 -0.32 8.95e-8 Pulmonary function; CESC cis rs2191566 0.576 rs393536 chr19:44493018 T/C cg20607764 chr19:44506953 ZNF230 0.44 5.67 0.33 3.63e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs832540 0.593 rs252912 chr5:56195792 C/T cg12311346 chr5:56204834 C5orf35 -0.45 -5.52 -0.32 8.16e-8 Coronary artery disease; CESC cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.19 0.3 4.29e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4253772 0.530 rs9615989 chr22:46803774 A/T cg18190219 chr22:46762943 CELSR1 -0.81 -6.13 -0.35 3.12e-9 LDL cholesterol;Cholesterol, total; CESC cis rs116095464 0.510 rs7723883 chr5:270798 T/C cg22857025 chr5:266934 NA -1.28 -18.48 -0.75 1.51e-49 Breast cancer; CESC cis rs1364705 0.955 rs4871600 chr8:120226576 C/G cg09273054 chr8:120220131 MAL2 -0.65 -7.15 -0.4 8.26e-12 Hippocampal atrophy; CESC cis rs4660261 0.526 rs2906466 chr1:44322220 A/G cg13606994 chr1:44402422 ARTN -0.35 -5.16 -0.3 4.91e-7 Intelligence (multi-trait analysis); CESC cis rs2455799 0.594 rs11128769 chr3:15926230 C/T cg16303742 chr3:15540471 COLQ -0.34 -5.34 -0.31 1.97e-7 Mean platelet volume; CESC cis rs11711311 0.747 rs11928494 chr3:113343219 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.44 5.86 0.34 1.38e-8 IgG glycosylation; CESC cis rs7843479 0.965 rs878872 chr8:21834567 A/G cg17168535 chr8:21777572 XPO7 0.51 7.09 0.4 1.23e-11 Mean corpuscular volume; CESC cis rs11792861 0.926 rs11788904 chr9:111865052 T/C cg13535736 chr9:111863775 C9orf5 -0.5 -6.65 -0.38 1.68e-10 Menarche (age at onset); CESC trans rs1728785 1.000 rs1364109 chr16:68595505 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.84 0.43 1.09e-13 Ulcerative colitis; CESC cis rs72387598 1 rs72387598 chr1:45922977 CAT/C cg06784218 chr1:46089804 CCDC17 0.35 5.52 0.32 8.19e-8 Platelet distribution width; CESC cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg21138405 chr5:131827807 IRF1 -0.6 -10.45 -0.54 1.29e-21 Asthma (sex interaction); CESC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg03609598 chr5:56110824 MAP3K1 -0.52 -5.5 -0.32 8.78e-8 Initial pursuit acceleration; CESC cis rs6570726 0.791 rs6914203 chr6:145899975 C/A cg05347473 chr6:146136440 FBXO30 0.54 7.13 0.4 9.5e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6788895 0.661 rs1533711 chr3:150469996 C/T cg09723797 chr3:150481914 SIAH2 -0.62 -5.56 -0.32 6.42e-8 Breast cancer; CESC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg26338869 chr17:61819248 STRADA 0.69 9.08 0.49 2.62e-17 Prudent dietary pattern; CESC cis rs2075371 0.932 rs1862048 chr7:133978167 C/G cg22540129 chr7:134855664 C7orf49 0.41 5.19 0.3 4.21e-7 Mean platelet volume; CESC cis rs35110281 0.805 rs4818855 chr21:45038951 C/T cg21573476 chr21:45109991 RRP1B -0.41 -5.75 -0.33 2.47e-8 Mean corpuscular volume; CESC cis rs7649275 0.882 rs2612023 chr3:53780217 T/C cg21503701 chr3:53781065 CACNA1D -0.4 -5.28 -0.31 2.66e-7 Trans fatty acid levels; CESC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg18032046 chr6:28092343 ZSCAN16 0.52 6.13 0.35 3.12e-9 Depression; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09529023 chr16:2097506 TSC2;NTHL1 -0.41 -6.17 -0.35 2.61e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs477692 0.647 rs524804 chr10:131430686 G/A cg24747557 chr10:131355152 MGMT 0.38 5.5 0.32 9.16e-8 Response to temozolomide; CESC cis rs11677416 1.000 rs2856837 chr2:113541925 G/A cg27083787 chr2:113543245 IL1A 0.61 7.53 0.42 7.75e-13 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs7824557 0.583 rs6601585 chr8:11233659 A/G cg21775007 chr8:11205619 TDH -0.55 -8.22 -0.45 9.13e-15 Retinal vascular caliber; CESC trans rs17536732 0.685 rs113735807 chr4:162851661 T/A cg12177677 chr2:158300475 CYTIP -0.64 -6.25 -0.36 1.62e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs9287719 0.935 rs61424402 chr2:10758371 T/A cg00105475 chr2:10696890 NA 0.39 5.65 0.33 4.2e-8 Prostate cancer; CESC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg11366901 chr6:160182831 ACAT2 0.8 10.56 0.54 5.43e-22 Age-related macular degeneration (geographic atrophy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25721516 chr17:42276931 ATXN7L3 0.55 6.02 0.35 5.8e-9 Gut microbiome composition (summer); CESC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg18876405 chr7:65276391 NA 0.47 5.25 0.31 3.18e-7 Aortic root size; CESC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg06028605 chr16:24865363 SLC5A11 0.55 8.31 0.45 5.1e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg13206674 chr6:150067644 NUP43 0.46 6.65 0.38 1.63e-10 Lung cancer; CESC cis rs67311347 0.955 rs12487955 chr3:40412853 T/C cg09455208 chr3:40491958 NA 0.53 9.01 0.48 4.18e-17 Renal cell carcinoma; CESC cis rs2228479 0.850 rs17227064 chr16:89816314 A/G cg00800038 chr16:89945340 TCF25 -0.91 -7.54 -0.42 7.39e-13 Skin colour saturation; CESC cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg06212747 chr3:49208901 KLHDC8B 0.64 8.55 0.46 9.98e-16 Parkinson's disease; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg23901904 chr1:10855062 CASZ1 0.47 6.23 0.36 1.87e-9 Weight; CESC cis rs9894429 0.621 rs7502337 chr17:79588470 T/C cg18240062 chr17:79603768 NPLOC4 0.5 6.56 0.37 2.89e-10 Eye color traits; CESC cis rs4236601 0.586 rs6466581 chr7:116162985 T/A cg12739419 chr7:116140593 CAV2 -0.3 -5.13 -0.3 5.56e-7 Intraocular pressure;Glaucoma (primary open-angle); CESC cis rs9911578 1.000 rs11870671 chr17:56605360 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.53 -0.32 7.63e-8 Intelligence (multi-trait analysis); CESC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs3091242 0.933 rs34933589 chr1:25788198 T/C cg27572855 chr1:25598939 RHD -0.43 -7.06 -0.4 1.42e-11 Erythrocyte sedimentation rate; CESC trans rs7246657 0.943 rs6508711 chr19:37815134 G/T cg24637308 chr11:6592297 DNHD1 0.53 6.24 0.36 1.74e-9 Coronary artery calcification; CESC cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg16144293 chr14:75469539 EIF2B2 0.39 5.03 0.3 9.09e-7 Height; CESC cis rs72945132 1.000 rs56913804 chr11:70114673 G/A cg00319359 chr11:70116639 PPFIA1 0.84 8.25 0.45 7.56e-15 Coronary artery disease; CESC cis rs17209837 0.607 rs4148820 chr7:87080482 T/C cg00919237 chr7:87102261 ABCB4 -0.48 -6.31 -0.36 1.17e-9 Gallbladder cancer; CESC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.88 0.34 1.23e-8 Tonsillectomy; CESC cis rs7116495 1.000 rs4945435 chr11:71759219 C/T cg26138937 chr11:71823887 C11orf51 -0.82 -6.93 -0.39 3.24e-11 Severe influenza A (H1N1) infection; CESC cis rs9309473 1.000 rs1114380 chr2:73804708 A/G cg20560298 chr2:73613845 ALMS1 -0.55 -7.22 -0.41 5.49e-12 Metabolite levels; CESC cis rs8077889 1.000 rs8077889 chr17:41878166 G/T cg26893861 chr17:41843967 DUSP3 -0.64 -7.71 -0.43 2.56e-13 Triglycerides; CESC cis rs7089973 0.604 rs7904188 chr10:116610271 G/C cg03647239 chr10:116582469 FAM160B1 0.43 5.35 0.31 1.94e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs17125944 0.686 rs7143400 chr14:53324891 A/C cg00686598 chr14:53173677 PSMC6 -0.67 -5.71 -0.33 3.04e-8 Alzheimer's disease (late onset); CESC cis rs17376456 0.932 rs3940842 chr5:93534858 C/A cg21475434 chr5:93447410 FAM172A 0.89 7.75 0.43 2e-13 Diabetic retinopathy; CESC cis rs12618769 0.597 rs11884553 chr2:99131206 T/C cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg17372223 chr3:52568218 NT5DC2 0.43 6.3 0.36 1.25e-9 Bipolar disorder; CESC cis rs66573146 0.808 rs55942328 chr4:6990960 T/G cg00086871 chr4:6988644 TBC1D14 1.18 7.59 0.42 5.45e-13 Granulocyte percentage of myeloid white cells; CESC cis rs6502050 0.835 rs7208673 chr17:80165908 G/C cg23985595 chr17:80112537 CCDC57 -0.4 -6.37 -0.36 8.19e-10 Life satisfaction; CESC cis rs698833 0.926 rs1067342 chr2:44622256 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 6.59 0.38 2.33e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs2708240 0.666 rs2710117 chr7:147601772 T/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.18e-8 QT interval (drug interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13069247 chr12:100967381 GAS2L3 0.47 6.04 0.35 5.06e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4253772 0.530 rs9615362 chr22:46795141 A/C cg18190219 chr22:46762943 CELSR1 0.47 5.83 0.34 1.62e-8 LDL cholesterol;Cholesterol, total; CESC cis rs12956009 0.518 rs11663852 chr18:44887542 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 6.81 0.39 6.63e-11 Educational attainment (years of education); CESC cis rs546131 0.890 rs485845 chr11:34830389 G/T cg06937548 chr11:34938143 PDHX;APIP -0.48 -5.75 -0.33 2.39e-8 Lung disease severity in cystic fibrosis; CESC trans rs11098499 0.564 rs11098507 chr4:120288286 G/A cg25214090 chr10:38739885 LOC399744 0.65 9.1 0.49 2.26e-17 Corneal astigmatism; CESC cis rs2710642 0.611 rs6752010 chr2:62859042 C/T cg17519650 chr2:63277830 OTX1 -0.47 -5.52 -0.32 8.17e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs36051895 0.589 rs62543574 chr9:5204090 A/T cg02405213 chr9:5042618 JAK2 -0.49 -5.69 -0.33 3.41e-8 Pediatric autoimmune diseases; CESC cis rs1865721 0.958 rs57073257 chr18:73172316 A/G cg26385618 chr18:73139727 C18orf62 -0.43 -6.46 -0.37 4.93e-10 Intelligence; CESC cis rs12618769 0.597 rs17033136 chr2:99149404 C/T cg10123293 chr2:99228465 UNC50 -0.38 -5.04 -0.3 8.8e-7 Bipolar disorder; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg00327537 chr2:74406064 MOBKL1B 0.45 6.22 0.36 1.96e-9 Thyroid stimulating hormone; CESC cis rs2040771 0.745 rs361956 chr22:19265799 C/T cg17887427 chr22:19166691 SLC25A1 -0.39 -5.05 -0.3 8.28e-7 Metabolite levels (small molecules and protein measures); CESC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg00934597 chr7:893267 UNC84A -0.51 -5.22 -0.31 3.63e-7 Cerebrospinal P-tau181p levels; CESC cis rs929354 0.742 rs886677 chr7:157003782 T/A cg05182265 chr7:156933206 UBE3C -0.49 -7.25 -0.41 4.51e-12 Body mass index; CESC cis rs8067354 0.830 rs57510610 chr17:57889406 T/A cg02344993 chr17:57696989 CLTC 0.48 6.3 0.36 1.2e-9 Hemoglobin concentration; CESC cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC cis rs2239547 0.618 rs1573815 chr3:52870132 A/G cg11645453 chr3:52864694 ITIH4 -0.36 -6.61 -0.38 2.16e-10 Schizophrenia; CESC cis rs155076 0.666 rs9509640 chr13:21872880 T/C cg11317459 chr13:21872234 NA 1.2 15.22 0.68 5.27e-38 White matter hyperintensity burden; CESC cis rs2820292 0.595 rs4950796 chr1:201835409 G/A cg11586189 chr1:201857591 SHISA4 -0.36 -5.65 -0.33 4.18e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs11608355 0.515 rs12579916 chr12:109924528 T/G cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC cis rs1957429 0.808 rs11628910 chr14:65332392 A/G cg23373153 chr14:65346875 NA 0.88 9.2 0.49 1.13e-17 Pediatric areal bone mineral density (radius); CESC cis rs71277158 0.688 rs77216745 chr3:169913020 A/T cg04067573 chr3:169899625 PHC3 0.67 6.4 0.37 7.18e-10 Prostate cancer; CESC cis rs548181 1.000 rs548181 chr11:125461709 A/G cg03464685 chr11:125439445 EI24 1.09 8.83 0.48 1.43e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs568617 0.859 rs1204650 chr11:65645580 A/C cg00576331 chr11:65640516 EFEMP2 0.45 5.3 0.31 2.48e-7 Crohn's disease; CESC cis rs8040855 0.658 rs11634877 chr15:85611477 G/A cg08123816 chr15:85640762 PDE8A -0.41 -6.01 -0.35 6.21e-9 Bulimia nervosa; CESC cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg03146154 chr1:46216737 IPP -0.44 -5.58 -0.32 5.84e-8 High light scatter reticulocyte count; CESC cis rs12545109 0.800 rs2610058 chr8:57409120 G/A cg09654669 chr8:57350985 NA -0.56 -6.65 -0.38 1.67e-10 Obesity-related traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03670158 chr17:41323431 NBR1 -0.43 -6.24 -0.36 1.73e-9 Gambling; CESC cis rs12477438 0.501 rs2632284 chr2:99775865 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.08 0.68 1.62e-37 Chronic sinus infection; CESC cis rs3749237 0.595 rs1464567 chr3:49459252 C/G cg03060546 chr3:49711283 APEH -0.73 -10.79 -0.55 9.43e-23 Resting heart rate; CESC cis rs2456568 0.900 rs1518571 chr11:93667420 C/A cg26875233 chr11:93583750 C11orf90 -0.29 -5.07 -0.3 7.58e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs763121 0.819 rs8137829 chr22:39061030 G/A cg14440974 chr22:39074834 NA -0.4 -5.5 -0.32 9.03e-8 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09138430 chr7:44084267 DBNL 0.61 7.24 0.41 4.98e-12 Gut microbiome composition (summer); CESC cis rs4629180 1.000 rs6744495 chr2:102099956 T/C cg04415270 chr2:102091202 RFX8 -0.46 -7.4 -0.41 1.76e-12 Chronic rhinosinusitis with nasal polyps; CESC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.48 0.42 1.1e-12 Tonsillectomy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03146079 chr4:2929622 ADD1 0.53 7.12 0.4 1.02e-11 Fibrinogen levels; CESC cis rs7809799 0.850 rs2395051 chr7:98761201 A/G cg05967295 chr7:98741636 SMURF1 -0.77 -5.41 -0.32 1.37e-7 Ulcerative colitis; CESC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.62 5.92 0.34 1.01e-8 Depression; CESC cis rs9929218 0.817 rs3114402 chr16:68719607 C/T cg02972257 chr16:68554789 NA 0.57 6.52 0.37 3.59e-10 Colorectal cancer; CESC cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg00701064 chr4:6280414 WFS1 0.74 13.26 0.63 4.04e-31 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs3026101 0.671 rs13341936 chr17:5298858 A/T cg25236894 chr17:5323110 RPAIN;NUP88 0.46 6.14 0.35 2.97e-9 Body mass index; CESC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg23758822 chr17:41437982 NA 0.99 14.89 0.68 7.27e-37 Menopause (age at onset); CESC cis rs6582630 0.519 rs7305570 chr12:38349285 G/A cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.62e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg20607287 chr7:12443886 VWDE -0.77 -9.04 -0.49 3.38e-17 Coronary artery disease; CESC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg22920501 chr2:26401640 FAM59B -0.96 -11.86 -0.59 2.62e-26 Gut microbiome composition (summer); CESC cis rs4253772 0.530 rs9615958 chr22:46751122 A/G cg10541313 chr22:46663664 TTC38 0.7 5.34 0.31 2.02e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6120849 0.707 rs6120826 chr20:33671831 G/A cg24642439 chr20:33292090 TP53INP2 0.67 6.62 0.38 1.94e-10 Protein C levels; CESC cis rs11577318 0.853 rs17645 chr1:26646730 A/G cg00852783 chr1:26633632 UBXN11 0.49 6.82 0.39 6.07e-11 Granulocyte percentage of myeloid white cells; CESC cis rs9527 0.637 rs11191424 chr10:104625886 G/A cg15744005 chr10:104629667 AS3MT -0.4 -6.01 -0.35 6.14e-9 Arsenic metabolism; CESC cis rs76419734 0.510 rs2553446 chr4:106696476 G/A cg24545054 chr4:106630052 GSTCD;INTS12 -0.58 -6.04 -0.35 5.28e-9 Post bronchodilator FEV1; CESC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg17143192 chr8:8559678 CLDN23 0.71 7.99 0.44 4.15e-14 Obesity-related traits; CESC cis rs3741151 0.881 rs7951174 chr11:73093135 G/C cg17517138 chr11:73019481 ARHGEF17 0.8 5.54 0.32 7.25e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg03352830 chr11:487213 PTDSS2 0.69 6.72 0.38 1.13e-10 Body mass index; CESC cis rs7927771 0.524 rs7101597 chr11:47797917 A/T cg20307385 chr11:47447363 PSMC3 0.62 8.69 0.47 3.96e-16 Subjective well-being; CESC cis rs9300255 0.602 rs1716172 chr12:123712712 G/T cg00376283 chr12:123451042 ABCB9 0.71 8.87 0.48 1.15e-16 Neutrophil percentage of white cells; CESC cis rs12681288 0.676 rs2701913 chr8:999982 A/T cg15309053 chr8:964076 NA 0.39 6.6 0.38 2.24e-10 Schizophrenia; CESC cis rs4689388 0.791 rs1046317 chr4:6304242 T/C cg14416269 chr4:6271139 WFS1 0.42 6.48 0.37 4.33e-10 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs11997175 0.838 rs10954934 chr8:33669637 T/C ch.8.33884649F chr8:33765107 NA 0.58 7.12 0.4 1.04e-11 Body mass index; CESC cis rs4595586 0.545 rs12827197 chr12:39404362 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg19539972 chr4:7069911 GRPEL1 0.77 9.71 0.51 2.99e-19 Monocyte percentage of white cells; CESC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg19346786 chr7:2764209 NA -0.46 -6.59 -0.38 2.34e-10 Height; CESC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg23161317 chr6:28129485 ZNF389 0.39 5.45 0.32 1.17e-7 Cardiac Troponin-T levels; CESC cis rs9488822 0.596 rs13206506 chr6:116324460 A/G cg15226275 chr6:116381976 FRK 0.23 5.54 0.32 7.24e-8 Cholesterol, total;LDL cholesterol; CESC cis rs7617773 0.817 rs9837228 chr3:48324466 A/T cg11946769 chr3:48343235 NME6 -0.82 -11.36 -0.57 1.24e-24 Coronary artery disease; CESC trans rs7142881 0.508 rs1954441 chr14:32118713 A/G cg10452522 chr19:34663544 LSM14A -0.42 -6.11 -0.35 3.53e-9 Response to iloperidone treatment (QT prolongation); CESC cis rs7809950 1.000 rs10243340 chr7:107090955 A/G cg23024343 chr7:107201750 COG5 -0.4 -5.63 -0.33 4.51e-8 Coronary artery disease; CESC cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg07507251 chr3:52567010 NT5DC2 -0.35 -6.34 -0.36 9.9e-10 Electroencephalogram traits; CESC cis rs1008375 1.000 rs10805357 chr4:17652352 G/A cg02297831 chr4:17616191 MED28 0.53 6.71 0.38 1.2e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6424115 0.830 rs2229585 chr1:24200921 T/C cg10978503 chr1:24200527 CNR2 0.33 6.64 0.38 1.73e-10 Immature fraction of reticulocytes; CESC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg06634786 chr22:41940651 POLR3H -0.65 -6.78 -0.38 7.73e-11 Vitiligo; CESC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg05863683 chr7:1912471 MAD1L1 0.37 5.38 0.31 1.64e-7 Bipolar disorder and schizophrenia; CESC cis rs6762477 0.748 rs11711407 chr3:50225029 A/G cg24308560 chr3:49941425 MST1R 0.4 5.07 0.3 7.31e-7 Menarche (age at onset); CESC cis rs5753618 0.509 rs1034589 chr22:31579233 C/T cg13145458 chr22:31556086 RNF185 0.45 5.05 0.3 8.36e-7 Colorectal cancer; CESC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg07414643 chr4:187882934 NA -0.47 -6.76 -0.38 8.84e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg06212747 chr3:49208901 KLHDC8B 0.69 9.19 0.49 1.22e-17 Parkinson's disease; CESC cis rs854765 0.565 rs4072738 chr17:17884547 A/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.48 6.76 0.38 9.02e-11 Total body bone mineral density; CESC cis rs1707322 0.721 rs9793568 chr1:46130373 G/A cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg05347473 chr6:146136440 FBXO30 0.57 7.24 0.41 4.72e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg17178900 chr1:205818956 PM20D1 0.88 15.71 0.69 9.2e-40 Menarche (age at onset); CESC cis rs9341808 1.000 rs9341808 chr6:80953257 C/A cg08355045 chr6:80787529 NA 0.31 5.04 0.3 8.66e-7 Sitting height ratio; CESC cis rs12681366 0.734 rs16916802 chr8:95409508 T/C cg13257157 chr8:95487014 RAD54B 0.37 5.09 0.3 6.85e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs7819412 0.740 rs7844536 chr8:11034028 A/G cg15556689 chr8:8085844 FLJ10661 -0.59 -6.89 -0.39 4.04e-11 Triglycerides; CESC cis rs9913156 0.515 rs11658808 chr17:4577112 C/T cg19197139 chr17:4613644 ARRB2 -0.63 -7.61 -0.42 4.88e-13 Lymphocyte counts; CESC cis rs9457247 0.534 rs4710154 chr6:167394634 A/T cg23791538 chr6:167370224 RNASET2 0.69 9.95 0.52 4.97e-20 Crohn's disease; CESC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg07157834 chr1:205819609 PM20D1 0.69 10.26 0.53 5.31e-21 Menarche (age at onset); CESC cis rs36051895 0.659 rs1322224 chr9:5267889 C/A cg02405213 chr9:5042618 JAK2 -0.48 -5.73 -0.33 2.73e-8 Pediatric autoimmune diseases; CESC cis rs7937682 0.847 rs11213948 chr11:111464401 G/A cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg17724175 chr1:150552817 MCL1 0.44 7.23 0.41 5.25e-12 Tonsillectomy; CESC cis rs9902453 0.833 rs7216631 chr17:28495112 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.43 0.46 2.29e-15 Coffee consumption (cups per day); CESC cis rs796364 0.806 rs112305133 chr2:201010380 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.64 -6.04 -0.35 5.26e-9 Schizophrenia; CESC cis rs2279817 0.675 rs1416853 chr1:18024880 G/C cg21791023 chr1:18019539 ARHGEF10L 0.53 7.75 0.43 1.98e-13 Neuroticism; CESC cis rs2249694 0.803 rs3020501 chr10:135381592 C/G cg20169779 chr10:135381914 SYCE1 0.4 5.66 0.33 3.91e-8 Obesity-related traits; CESC cis rs6500395 1.000 rs7187513 chr16:48591638 T/C cg04672837 chr16:48644449 N4BP1 0.5 6.23 0.36 1.78e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11658311 0.850 rs11651383 chr17:17657478 C/T cg01883427 chr16:15242839 NA 0.6 6.31 0.36 1.17e-9 Obsessive-compulsive symptoms; CESC cis rs5753037 0.653 rs131277 chr22:30154101 C/A cg01021169 chr22:30184971 ASCC2 -0.45 -6.32 -0.36 1.11e-9 Type 1 diabetes; CESC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.62 0.64 2.27e-32 Prudent dietary pattern; CESC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg03188948 chr7:1209495 NA 0.68 6.75 0.38 9.19e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs854765 0.547 rs7212167 chr17:17913504 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.56 7.96 0.44 5.18e-14 Total body bone mineral density; CESC cis rs12142240 0.698 rs66972124 chr1:46807445 A/G cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg16049864 chr8:95962084 TP53INP1 -0.72 -13.04 -0.63 2.36e-30 Type 2 diabetes; CESC cis rs703842 1.000 rs10431505 chr12:58178589 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.7 9.07 0.49 2.69e-17 Multiple sclerosis; CESC cis rs3796352 1.000 rs11707780 chr3:53084326 A/G cg12962167 chr3:53033115 SFMBT1 -0.57 -5.99 -0.35 6.67e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg12463550 chr7:65579703 CRCP -0.57 -7.35 -0.41 2.54e-12 Aortic root size; CESC cis rs9596863 0.851 rs1379832 chr13:54429818 C/T ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.39 7.14 0.4 9.08e-12 Electroencephalogram traits; CESC cis rs2011503 1.000 rs11670761 chr19:19649327 G/C cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC cis rs4481887 0.927 rs4517383 chr1:248426484 C/T cg00666640 chr1:248458726 OR2T12 0.36 6.26 0.36 1.55e-9 Common traits (Other); CESC cis rs3806843 1.000 rs3806845 chr5:140180737 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.16 -0.3 4.96e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2820292 0.710 rs2047264 chr1:201886402 C/T cg11586189 chr1:201857591 SHISA4 0.32 5.33 0.31 2.11e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs9300255 0.722 rs10846515 chr12:123801672 T/G cg19016782 chr12:123741754 C12orf65 -0.43 -6.0 -0.35 6.54e-9 Neutrophil percentage of white cells; CESC cis rs9926296 0.624 rs1110331 chr16:89774396 A/G cg03605463 chr16:89740564 NA 0.47 5.95 0.34 8.51e-9 Vitiligo; CESC cis rs7937682 0.663 rs7116280 chr11:111659111 T/C cg22437258 chr11:111473054 SIK2 -0.51 -5.44 -0.32 1.18e-7 Primary sclerosing cholangitis; CESC cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg11812906 chr14:75593930 NEK9 -0.78 -12.28 -0.6 9.89e-28 Height; CESC cis rs10979 1.000 rs9496673 chr6:143885393 C/G cg25407410 chr6:143891975 LOC285740 -0.62 -9.51 -0.5 1.21e-18 Hypospadias; CESC trans rs116095464 0.850 rs10055295 chr5:243749 G/A cg00938859 chr5:1591904 SDHAP3 0.64 6.98 0.39 2.36e-11 Breast cancer; CESC cis rs1008375 1.000 rs4235388 chr4:17682030 G/A cg02297831 chr4:17616191 MED28 0.45 5.74 0.33 2.6e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7312774 0.618 rs7979117 chr12:107345883 C/T cg16260113 chr12:107380972 MTERFD3 0.8 7.35 0.41 2.42e-12 Severe influenza A (H1N1) infection; CESC cis rs10779751 1.000 rs11121711 chr1:11317661 A/T cg08854313 chr1:11322531 MTOR 0.84 11.96 0.59 1.16e-26 Body mass index; CESC cis rs9354308 1.000 rs9360161 chr6:66565457 C/T cg07460842 chr6:66804631 NA 0.51 6.16 0.35 2.64e-9 Metabolite levels; CESC cis rs965469 0.901 rs6139080 chr20:3314506 A/G cg25506879 chr20:3388711 C20orf194 -0.51 -5.65 -0.33 4.06e-8 IFN-related cytopenia; CESC cis rs11638352 0.661 rs2706492 chr15:44423846 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -5.29 -0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg03609598 chr5:56110824 MAP3K1 -0.51 -5.32 -0.31 2.22e-7 Initial pursuit acceleration; CESC cis rs28647808 0.786 rs4962136 chr9:136256794 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs1008375 1.000 rs1121090 chr4:17676437 C/G cg16339924 chr4:17578868 LAP3 0.51 6.44 0.37 5.73e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg02475777 chr4:1388615 CRIPAK -0.71 -8.98 -0.48 5.19e-17 Longevity; CESC cis rs7296418 0.663 rs28450974 chr12:123861420 G/A cg00376283 chr12:123451042 ABCB9 0.58 7.83 0.43 1.16e-13 Platelet count; CESC cis rs6728642 0.708 rs115507803 chr2:97752054 T/C cg26665480 chr2:98280029 ACTR1B -0.84 -6.63 -0.38 1.83e-10 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs1008375 0.900 rs4698622 chr4:17589557 C/T cg27347728 chr4:17578864 LAP3 0.49 5.61 0.33 5.07e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs734999 0.505 rs4073286 chr1:2539901 A/C cg18854424 chr1:2615690 NA 0.3 5.97 0.34 7.58e-9 Ulcerative colitis; CESC cis rs796364 0.806 rs34510964 chr2:201010676 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.64 -6.04 -0.35 5.26e-9 Schizophrenia; CESC cis rs1048257 0.553 rs2819421 chr14:105408811 A/G cg20257916 chr14:105219517 SIVA1 0.41 5.18 0.3 4.38e-7 Systemic lupus erythematosus; CESC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg11644478 chr21:40555479 PSMG1 0.93 13.15 0.63 9.78e-31 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07135626 chr7:73588538 EIF4H 0.58 6.65 0.38 1.62e-10 Gut microbiome composition (summer); CESC cis rs11048434 0.698 rs10842537 chr12:9066158 T/C cg04155231 chr12:9217510 LOC144571 0.33 5.35 0.31 1.9e-7 Sjögren's syndrome; CESC trans rs7246657 0.714 rs12972195 chr19:37752505 T/C cg01833234 chr11:6592585 DNHD1 0.52 6.03 0.35 5.59e-9 Coronary artery calcification; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19996838 chr1:244211323 NA 0.52 6.81 0.39 6.37e-11 Gut microbiota (bacterial taxa); CESC cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg03433033 chr1:76189801 ACADM 0.75 10.47 0.54 1.06e-21 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg03407747 chr17:6899364 ALOX12 -0.5 -8.79 -0.47 1.99e-16 Tonsillectomy; CESC cis rs12540874 0.794 rs1470750 chr7:50576648 C/G cg18232548 chr7:50535776 DDC -0.41 -5.5 -0.32 8.91e-8 Systemic sclerosis; CESC cis rs12681288 0.550 rs72507624 chr8:961324 G/A cg15309053 chr8:964076 NA 0.55 9.11 0.49 2.08e-17 Schizophrenia; CESC cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg14345882 chr6:26364793 BTN3A2 0.41 5.12 0.3 5.79e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs453301 0.653 rs11784393 chr8:8903134 C/T cg06636001 chr8:8085503 FLJ10661 0.51 6.54 0.37 3.19e-10 Joint mobility (Beighton score); CESC cis rs2243480 0.803 rs34804747 chr7:65412942 G/C cg18252515 chr7:66147081 NA -1.01 -9.32 -0.5 4.6e-18 Diabetic kidney disease; CESC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.4 0.54 1.87e-21 Prudent dietary pattern; CESC cis rs2479724 0.846 rs2254805 chr6:41846110 T/G cg08135965 chr6:41755394 TOMM6 0.41 5.52 0.32 8.22e-8 Menarche (age at onset); CESC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24856420 chr20:46130460 NCOA3 0.56 6.63 0.38 1.92e-10 Gut microbiome composition (summer); CESC cis rs1215050 0.904 rs260898 chr4:98706492 C/G cg05340658 chr4:99064831 C4orf37 -0.45 -5.21 -0.3 3.79e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg12463550 chr7:65579703 CRCP 0.56 7.05 0.4 1.52e-11 Aortic root size; CESC cis rs17253792 0.822 rs112739186 chr14:56065167 A/T cg01858014 chr14:56050164 KTN1 -0.96 -7.13 -0.4 9.72e-12 Putamen volume; CESC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg24531977 chr5:56204891 C5orf35 -0.88 -11.15 -0.57 6.07e-24 Initial pursuit acceleration; CESC cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg18180107 chr4:99064573 C4orf37 0.39 5.05 0.3 8.12e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.64 0.47 5.5e-16 Menopause (age at onset); CESC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL -0.36 -5.7 -0.33 3.21e-8 Personality dimensions; CESC cis rs6121246 0.821 rs6119718 chr20:30331074 A/G cg13852791 chr20:30311386 BCL2L1 0.82 8.74 0.47 2.63e-16 Mean corpuscular hemoglobin; CESC cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.09e-28 Colonoscopy-negative controls vs population controls; CESC cis rs472402 0.580 rs6884552 chr5:6661966 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.49 -6.39 -0.37 7.51e-10 Response to amphetamines; CESC cis rs4423214 1.000 rs4944956 chr11:71167765 C/T cg05163923 chr11:71159392 DHCR7 0.84 11.56 0.58 2.73e-25 Vitamin D levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10714403 chr17:55162284 AKAP1 0.55 6.23 0.36 1.82e-9 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04902049 chr1:36622448 MAP7D1 -0.43 -6.35 -0.36 9.08e-10 Gambling; CESC trans rs948562 0.744 rs12363774 chr11:58225035 G/T cg24637035 chr12:120445227 CCDC64 -0.52 -6.26 -0.36 1.58e-9 Lymphoma; CESC cis rs17826219 0.636 rs8080829 chr17:29058730 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Body mass index; CESC cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg24308560 chr3:49941425 MST1R -0.64 -9.35 -0.5 3.91e-18 Intelligence (multi-trait analysis); CESC cis rs854765 0.533 rs2955354 chr17:17948716 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.33 -0.36 1.03e-9 Total body bone mineral density; CESC cis rs10463316 0.862 rs13354553 chr5:150758128 G/A cg03212797 chr5:150827313 SLC36A1 -0.52 -6.83 -0.39 5.75e-11 Metabolite levels (Pyroglutamine); CESC cis rs9858542 0.953 rs4625 chr3:49572140 A/G cg07274523 chr3:49395745 GPX1 0.65 8.48 0.46 1.59e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs2502399 0.652 rs2502371 chr6:113506182 C/A cg00285294 chr7:1089767 C7orf50 -0.34 -6.36 -0.36 8.86e-10 Plasma clusterin levels; CESC trans rs61869271 0.797 rs6585313 chr10:116745558 T/A cg17463145 chr7:79084011 MAGI2 0.32 6.36 0.36 8.92e-10 Tonsillectomy; CESC cis rs1775715 0.870 rs1775737 chr10:32256871 T/C cg18675610 chr10:32216311 ARHGAP12 0.32 5.11 0.3 6.16e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg19346786 chr7:2764209 NA -0.41 -6.1 -0.35 3.8e-9 Height; CESC cis rs7824557 0.933 rs6601576 chr8:11100275 A/T cg21775007 chr8:11205619 TDH -0.37 -5.5 -0.32 9.05e-8 Retinal vascular caliber; CESC cis rs2274273 0.662 rs60445539 chr14:55624245 C/T cg04306507 chr14:55594613 LGALS3 0.31 5.26 0.31 2.99e-7 Protein biomarker; CESC cis rs924607 1.000 rs12523022 chr5:598643 C/T cg09021430 chr5:549028 NA 0.39 6.96 0.39 2.61e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs75477785 0.590 rs4545339 chr1:209912742 C/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.8 5.15 0.3 5.1e-7 Cleft lip with or without cleft palate; CESC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg26343298 chr8:95960752 TP53INP1 0.35 5.7 0.33 3.19e-8 Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12588470 chr4:89444909 PIGY -0.48 -6.49 -0.37 4.25e-10 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27130364 chr5:36151796 LMBRD2;SKP2 -0.48 -6.68 -0.38 1.38e-10 Fibrinogen levels; CESC cis rs897984 0.568 rs8063565 chr16:30883965 G/C cg02466173 chr16:30829666 NA 0.45 6.56 0.37 2.82e-10 Dementia with Lewy bodies; CESC cis rs4722166 0.532 rs4719712 chr7:22755807 C/T cg05472934 chr7:22766657 IL6 0.52 6.92 0.39 3.39e-11 Lung cancer; CESC trans rs9467711 0.606 rs9379901 chr6:26603866 T/C cg01620082 chr3:125678407 NA -0.64 -6.33 -0.36 1.03e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg18099408 chr3:52552593 STAB1 -0.31 -5.27 -0.31 2.85e-7 Electroencephalogram traits; CESC cis rs8077889 0.917 rs9894873 chr17:41911832 A/G cg26893861 chr17:41843967 DUSP3 0.74 9.32 0.5 4.61e-18 Triglycerides; CESC cis rs9435341 0.965 rs1730862 chr1:107614003 G/A cg09367891 chr1:107599246 PRMT6 -0.69 -8.29 -0.45 5.81e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs9399135 1.000 rs4896130 chr6:135355118 C/T cg24558204 chr6:135376177 HBS1L 0.49 6.66 0.38 1.53e-10 Red blood cell count; CESC cis rs12995491 0.843 rs1878809 chr2:88518315 C/T cg07952391 chr2:88470173 THNSL2 -0.56 -8.11 -0.45 1.89e-14 Response to metformin (IC50); CESC cis rs34779708 0.931 rs10508815 chr10:35332621 A/C cg03585969 chr10:35415529 CREM 0.77 10.3 0.53 3.95e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs9291683 0.551 rs2240720 chr4:10020480 C/T cg00071950 chr4:10020882 SLC2A9 0.92 17.67 0.74 1.1e-46 Bone mineral density; CESC cis rs2625529 0.761 rs972028 chr15:72173092 C/T cg16672083 chr15:72433130 SENP8 -0.4 -5.38 -0.31 1.63e-7 Red blood cell count; CESC cis rs7845219 0.525 rs7820818 chr8:95919231 G/A cg16049864 chr8:95962084 TP53INP1 -0.51 -7.48 -0.42 1.09e-12 Type 2 diabetes; CESC cis rs9300255 0.544 rs1727309 chr12:123658258 A/G cg00376283 chr12:123451042 ABCB9 0.61 6.2 0.36 2.2e-9 Neutrophil percentage of white cells; CESC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.16e-7 Aortic root size; CESC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg08027265 chr7:2291960 NA -0.35 -5.26 -0.31 3.02e-7 Bipolar disorder and schizophrenia; CESC cis rs7312933 0.558 rs1669936 chr12:42813509 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.51 -6.75 -0.38 9.47e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs17376456 0.877 rs10057605 chr5:93443950 T/G cg21475434 chr5:93447410 FAM172A 0.91 7.7 0.43 2.71e-13 Diabetic retinopathy; CESC cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.96e-28 Colonoscopy-negative controls vs population controls; CESC cis rs1461503 0.966 rs7944630 chr11:122838844 G/A cg27398637 chr11:122830231 C11orf63 -0.56 -8.42 -0.46 2.35e-15 Menarche (age at onset); CESC cis rs28829049 0.597 rs72651403 chr1:19519887 G/C cg13387374 chr1:19411106 UBR4 0.45 5.8 0.34 1.85e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs1215050 0.791 rs984940 chr4:98811756 T/A cg05340658 chr4:99064831 C4orf37 0.52 6.82 0.39 6.19e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7267979 1.000 rs6037099 chr20:25356876 T/G cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.88e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9457247 0.765 rs6900701 chr6:167434112 A/G cg23791538 chr6:167370224 RNASET2 -0.52 -7.17 -0.4 7.67e-12 Crohn's disease; CESC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg16743903 chr16:89593216 SPG7 -0.49 -6.3 -0.36 1.21e-9 Multiple myeloma (IgH translocation); CESC cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg08917208 chr2:24149416 ATAD2B 0.63 6.02 0.35 5.68e-9 Lymphocyte counts; CESC cis rs9640161 0.830 rs3735165 chr7:150068371 T/C cg21361702 chr7:150065534 REPIN1 0.5 6.59 0.38 2.38e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs62432291 0.681 rs378339 chr6:159658852 C/T cg14500486 chr6:159655392 FNDC1 -0.62 -6.34 -0.36 9.83e-10 Joint mobility (Beighton score); CESC cis rs7918232 0.574 rs10458708 chr10:27455605 C/T cg14240646 chr10:27532245 ACBD5 -0.75 -10.83 -0.55 7.44e-23 Breast cancer; CESC cis rs6542838 0.588 rs4851175 chr2:99530118 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -5.98 -0.34 7.18e-9 Fear of minor pain; CESC cis rs714031 0.730 rs5757766 chr22:40069490 T/C cg21377881 chr22:40064566 CACNA1I -0.32 -5.1 -0.3 6.38e-7 Schizophrenia; CESC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg00166722 chr3:10149974 C3orf24 0.46 5.78 0.33 2.08e-8 Alzheimer's disease; CESC cis rs709400 1.000 rs56660916 chr14:104126137 G/T cg12935359 chr14:103987150 CKB -0.45 -6.08 -0.35 4.23e-9 Body mass index; CESC cis rs8114671 0.562 rs6088642 chr20:33483186 G/T cg07148914 chr20:33460835 GGT7 0.45 5.9 0.34 1.09e-8 Height; CESC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg00149659 chr3:10157352 C3orf10 1.02 12.77 0.62 1.96e-29 Alzheimer's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01391346 chr6:99873300 SFRS18 0.47 6.46 0.37 4.94e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1691799 0.867 rs1039056 chr12:66760391 C/T cg16791601 chr12:66731901 HELB -0.77 -13.34 -0.63 2.15e-31 White blood cell count (basophil); CESC cis rs28647808 0.786 rs28590601 chr9:136256224 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs12477438 0.798 rs10167015 chr2:99570707 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.69 -10.09 -0.53 1.85e-20 Chronic sinus infection; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12542604 chr6:34856704 ANKS1A;TAF11 -0.46 -6.09 -0.35 3.89e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3733585 0.598 rs28677023 chr4:9958326 C/A cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg26314531 chr2:26401878 FAM59B -0.62 -7.07 -0.4 1.37e-11 Gut microbiome composition (summer); CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg05564831 chr3:52568323 NT5DC2 0.55 9.47 0.5 1.61e-18 Electroencephalogram traits; CESC cis rs921968 0.608 rs7598056 chr2:219352511 A/C cg02176678 chr2:219576539 TTLL4 0.42 7.49 0.42 1.04e-12 Mean corpuscular hemoglobin concentration; CESC cis rs3820068 0.705 rs4646087 chr1:15822404 A/G cg17385448 chr1:15911702 AGMAT 0.4 6.12 0.35 3.37e-9 Systolic blood pressure; CESC cis rs2576037 0.901 rs2060416 chr18:44576240 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -9.14 -0.49 1.66e-17 Personality dimensions; CESC cis rs10189230 0.546 rs6436266 chr2:222357235 T/C cg14652038 chr2:222343519 EPHA4 0.33 5.66 0.33 3.9e-8 Urate levels in lean individuals; CESC cis rs2204008 0.837 rs11180821 chr12:38242843 A/G cg26384229 chr12:38710491 ALG10B 0.64 8.89 0.48 9.98e-17 Bladder cancer; CESC cis rs72781680 0.898 rs72786278 chr2:24063243 C/T cg20701182 chr2:24300061 SF3B14 0.62 5.6 0.33 5.24e-8 Lymphocyte counts; CESC cis rs12682352 0.602 rs11783966 chr8:8665147 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -5.34 -0.31 2.03e-7 Neuroticism; CESC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.55 -0.32 7e-8 Total body bone mineral density; CESC cis rs10129255 0.518 rs8004895 chr14:107193377 T/C cg23076370 chr14:107095027 NA -0.65 -9.53 -0.51 1.09e-18 Kawasaki disease; CESC cis rs6120849 0.707 rs6088694 chr20:33652371 G/A cg24642439 chr20:33292090 TP53INP2 0.67 6.62 0.38 1.94e-10 Protein C levels; CESC cis rs10089 1.000 rs3792866 chr5:127479900 A/G cg19767477 chr5:127420684 SLC12A2 -0.39 -5.17 -0.3 4.62e-7 Ileal carcinoids; CESC trans rs2502399 0.689 rs1040590 chr6:113491019 T/C cg00285294 chr7:1089767 C7orf50 -0.35 -6.41 -0.37 6.56e-10 Plasma clusterin levels; CESC cis rs300703 0.719 rs400040 chr2:199422 G/T cg21211680 chr2:198530 NA 1.02 10.89 0.56 4.57e-23 Blood protein levels; CESC cis rs72627509 0.904 rs58408429 chr4:57769824 T/C cg26694713 chr4:57773883 REST 0.58 5.55 0.32 6.87e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs7264396 0.790 rs6060539 chr20:34239382 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 3.14e-26 Total cholesterol levels; CESC cis rs57221529 0.654 rs77015126 chr5:670909 G/A cg16447950 chr5:562315 NA -0.67 -7.09 -0.4 1.22e-11 Lung disease severity in cystic fibrosis; CESC cis rs7208859 0.623 rs7214570 chr17:29147164 A/G cg19761014 chr17:28927070 LRRC37B2 0.71 6.02 0.35 5.85e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs17666538 0.535 rs896522 chr8:616991 A/G cg02524346 chr8:600233 NA 0.86 6.17 0.35 2.53e-9 IgG glycosylation; CESC cis rs2404602 0.692 rs1838048 chr15:76931679 A/G cg22467129 chr15:76604101 ETFA -0.36 -5.24 -0.31 3.26e-7 Blood metabolite levels; CESC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg09165964 chr15:75287851 SCAMP5 0.49 6.49 0.37 4.14e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg11764359 chr7:65958608 NA -0.76 -10.75 -0.55 1.3e-22 Aortic root size; CESC cis rs9583531 0.527 rs12875067 chr13:111365104 A/G cg15841412 chr13:111365552 ING1 0.48 6.22 0.36 1.93e-9 Coronary artery disease; CESC cis rs16854884 0.657 rs7642774 chr3:143723272 T/A cg06585982 chr3:143692056 C3orf58 0.48 6.17 0.35 2.54e-9 Economic and political preferences (feminism/equality); CESC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg08736216 chr1:53307985 ZYG11A -0.41 -6.84 -0.39 5.42e-11 Monocyte count; CESC cis rs2180341 1.000 rs6569483 chr6:127658855 G/A cg24812749 chr6:127587940 RNF146 1.07 15.4 0.69 1.16e-38 Breast cancer; CESC cis rs34172651 0.537 rs8049014 chr16:24698903 A/G cg06505273 chr16:24850292 NA 0.46 5.63 0.33 4.6e-8 Intelligence (multi-trait analysis); CESC cis rs7103648 0.695 rs6485758 chr11:47530024 G/A cg20307385 chr11:47447363 PSMC3 0.84 12.54 0.61 1.2e-28 Diastolic blood pressure;Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04811502 chr14:21979673 METTL3 -0.66 -8.18 -0.45 1.21e-14 Gut microbiome composition (summer); CESC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg18446336 chr7:2847575 GNA12 -0.37 -5.65 -0.33 4.17e-8 Height; CESC cis rs73206853 0.841 rs73206854 chr12:110731375 C/T cg12870014 chr12:110450643 ANKRD13A 0.62 5.13 0.3 5.68e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs854765 0.583 rs8078583 chr17:17811465 C/T cg04398451 chr17:18023971 MYO15A -0.65 -9.23 -0.49 9.1e-18 Total body bone mineral density; CESC cis rs10242455 0.867 rs2687077 chr7:99306566 C/T cg07715041 chr7:99302981 CYP3A7 -0.41 -5.21 -0.3 3.78e-7 Blood metabolite levels; CESC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg02951883 chr7:2050386 MAD1L1 -0.41 -5.4 -0.31 1.46e-7 Bipolar disorder and schizophrenia; CESC cis rs4253772 0.530 rs9615933 chr22:46677298 G/A cg18190219 chr22:46762943 CELSR1 -0.59 -5.68 -0.33 3.46e-8 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02259255 chr5:176944032 DDX41 0.55 6.42 0.37 6.19e-10 Gut microbiome composition (summer); CESC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg22800045 chr5:56110881 MAP3K1 -0.68 -7.61 -0.42 4.77e-13 Initial pursuit acceleration; CESC cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg12193833 chr17:30244370 NA -0.71 -6.55 -0.37 3.04e-10 Hip circumference adjusted for BMI; CESC cis rs854765 0.724 rs62072049 chr17:17906520 T/C cg16928487 chr17:17741425 SREBF1 -0.58 -10.31 -0.53 3.59e-21 Total body bone mineral density; CESC cis rs12618769 0.625 rs12618524 chr2:99064029 T/A cg10123293 chr2:99228465 UNC50 0.39 5.18 0.3 4.49e-7 Bipolar disorder; CESC cis rs12325245 0.536 rs34676074 chr16:58549321 G/C cg02549819 chr16:58548995 SETD6 0.97 6.12 0.35 3.44e-9 Schizophrenia; CESC trans rs79976124 0.837 rs11751145 chr6:66642039 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 8.24 0.45 7.81e-15 Type 2 diabetes; CESC trans rs239339 1.000 rs239339 chr1:4444539 A/C cg06451177 chr17:79412583 BAHCC1 -0.5 -6.03 -0.35 5.53e-9 Obesity-related traits; CESC cis rs6964587 1.000 rs6953515 chr7:91658620 C/T cg17063962 chr7:91808500 NA 0.54 7.38 0.41 2.03e-12 Breast cancer; CESC cis rs708547 0.874 rs1718837 chr4:57871203 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -6.33 -0.36 1.04e-9 Response to bleomycin (chromatid breaks); CESC cis rs2204008 0.597 rs4002591 chr12:38133841 A/G cg26384229 chr12:38710491 ALG10B 0.71 10.13 0.53 1.3e-20 Bladder cancer; CESC cis rs10504229 0.680 rs11777459 chr8:58044241 A/T cg22535103 chr8:58192502 C8orf71 -0.67 -7.27 -0.41 4.08e-12 Developmental language disorder (linguistic errors); CESC cis rs1003719 0.708 rs2000417 chr21:38502868 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.47 -0.46 1.69e-15 Eye color traits; CESC cis rs6499188 0.571 rs1645975 chr16:68564448 C/T cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs1008375 0.966 rs28441502 chr4:17598384 G/A cg16339924 chr4:17578868 LAP3 0.65 8.19 0.45 1.15e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs919433 1.000 rs2195510 chr2:198161195 A/G cg10820045 chr2:198174542 NA -0.43 -6.56 -0.37 2.76e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs6732160 0.706 rs1430348 chr2:73367058 C/T cg01422370 chr2:73384389 NA 0.41 6.84 0.39 5.58e-11 Intelligence (multi-trait analysis); CESC cis rs4953318 0.619 rs10183887 chr2:46361808 T/A cg12428440 chr2:46370979 PRKCE 0.5 6.68 0.38 1.4e-10 Red blood cell count;Hematocrit;Red blood cell traits; CESC cis rs1045714 0.887 rs73033694 chr7:2637139 G/A cg20813462 chr7:2646259 IQCE 0.67 5.8 0.34 1.92e-8 Urate levels in lean individuals; CESC trans rs7246760 1.000 rs10425775 chr19:9912917 G/A cg02900749 chr2:68251473 NA -0.73 -6.52 -0.37 3.46e-10 Pursuit maintenance gain; CESC cis rs858239 0.863 rs274054 chr7:23390467 G/C cg23682824 chr7:23144976 KLHL7 0.44 5.89 0.34 1.17e-8 Cerebrospinal fluid biomarker levels; CESC cis rs1215050 0.904 rs890469 chr4:98923293 T/C cg05340658 chr4:99064831 C4orf37 -0.54 -6.69 -0.38 1.36e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4692589 1.000 rs4519759 chr4:170933919 T/C cg19918862 chr4:170955249 NA 0.37 5.83 0.34 1.59e-8 Anxiety disorder; CESC cis rs12474201 0.928 rs13429704 chr2:46960329 G/T cg06386533 chr2:46925753 SOCS5 0.82 11.49 0.58 4.62e-25 Height; CESC cis rs2637266 0.703 rs846625 chr10:78541353 T/G cg18941641 chr10:78392320 NA 0.4 7.74 0.43 2.12e-13 Pulmonary function; CESC cis rs12368653 0.693 rs2640610 chr12:58037435 T/A cg00700412 chr12:58011837 NA 0.36 5.43 0.32 1.25e-7 Multiple sclerosis; CESC cis rs2733201 1.000 rs2412849 chr15:44276555 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.52 -5.42 -0.32 1.36e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs3749237 0.595 rs7643845 chr3:49530711 A/G cg03060546 chr3:49711283 APEH 0.77 11.82 0.59 3.5e-26 Resting heart rate; CESC cis rs728616 0.867 rs118134654 chr10:81744381 G/A cg05935833 chr10:81318306 SFTPA2 -0.52 -5.06 -0.3 7.72e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9660992 0.674 rs1151785 chr1:205232299 C/T cg21643547 chr1:205240462 TMCC2 -0.47 -6.34 -0.36 1.01e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs7799006 0.722 rs33981648 chr7:2288669 T/C cg12745145 chr7:2261452 MAD1L1 -0.34 -5.29 -0.31 2.56e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07822143 chr4:146019674 ABCE1;ANAPC10 0.44 6.17 0.35 2.59e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2749592 0.550 rs7917262 chr10:37874602 A/C cg00409905 chr10:38381863 ZNF37A 0.43 5.79 0.34 1.96e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4975709 0.569 rs931509 chr5:1858821 A/T cg12288994 chr5:1860383 NA 0.43 6.94 0.39 2.99e-11 Cardiovascular disease risk factors; CESC cis rs17023223 0.537 rs12087987 chr1:119734821 C/A cg05756136 chr1:119680316 WARS2 -0.47 -5.72 -0.33 2.81e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs2456568 0.548 rs7105031 chr11:93661207 C/T cg26875233 chr11:93583750 C11orf90 -0.33 -5.84 -0.34 1.52e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs9910055 0.529 rs183462 chr17:42183376 G/C cg19774624 chr17:42201019 HDAC5 0.61 8.44 0.46 2.14e-15 Total body bone mineral density; CESC cis rs16937 0.711 rs10751430 chr1:205107497 A/G cg00857998 chr1:205179979 DSTYK 0.39 5.25 0.31 3.11e-7 Schizophrenia; CESC cis rs3096299 0.967 rs753853 chr16:89446525 G/T cg02187348 chr16:89574699 SPG7 0.56 7.25 0.41 4.68e-12 Multiple myeloma (IgH translocation); CESC cis rs3892630 1.000 rs3892630 chr19:33181484 A/G cg13157960 chr19:33183277 NUDT19 -0.56 -5.51 -0.32 8.34e-8 Red blood cell traits; CESC trans rs7246657 0.943 rs2126977 chr19:37995747 C/G cg01833234 chr11:6592585 DNHD1 -0.51 -6.06 -0.35 4.65e-9 Coronary artery calcification; CESC cis rs11608355 0.521 rs4766595 chr12:109846998 A/T cg19025524 chr12:109796872 NA -0.52 -7.0 -0.39 2.13e-11 Neuroticism; CESC cis rs763121 0.925 rs17032 chr22:39130843 C/G cg06544989 chr22:39130855 UNC84B 0.52 10.04 0.53 2.52e-20 Menopause (age at onset); CESC cis rs911555 0.692 rs60235428 chr14:103904350 T/C cg12935359 chr14:103987150 CKB 0.66 9.72 0.51 2.74e-19 Intelligence (multi-trait analysis); CESC cis rs6076065 0.748 rs6076055 chr20:23333917 G/C cg11657817 chr20:23433608 CST11 0.42 6.36 0.36 8.65e-10 Facial morphology (factor 15, philtrum width); CESC cis rs933688 1.000 rs2367526 chr5:90740525 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 11.04 0.56 1.47e-23 Smoking behavior; CESC cis rs7107174 0.901 rs10899498 chr11:78124575 C/G cg02023728 chr11:77925099 USP35 0.37 5.14 0.3 5.35e-7 Testicular germ cell tumor; CESC cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.75 0.51 2.18e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs8114671 0.527 rs6088650 chr20:33514465 C/T cg07148914 chr20:33460835 GGT7 -0.45 -5.97 -0.34 7.5e-9 Height; CESC cis rs698833 0.692 rs786410 chr2:44731156 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.56 6.83 0.39 5.81e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs5753618 0.561 rs5753521 chr22:31638027 T/C cg13145458 chr22:31556086 RNF185 0.46 5.19 0.3 4.27e-7 Colorectal cancer; CESC trans rs1814175 0.791 rs11040472 chr11:49703116 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.79 -0.77 3.87e-54 Height; CESC cis rs7071206 0.947 rs1356090 chr10:79395312 T/C cg23888215 chr10:79422304 NA -0.54 -5.78 -0.33 2.15e-8 Bone mineral density; CESC cis rs57506017 0.585 rs12699332 chr7:12269762 G/T cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.58e-7 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23319546 chr10:75173760 ANXA7 -0.59 -6.45 -0.37 5.17e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08853494 chr4:76439657 RCHY1;THAP6 0.6 6.56 0.37 2.74e-10 Gut microbiome composition (summer); CESC cis rs58785573 0.504 rs11947292 chr4:38634749 A/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.5 7.11 0.4 1.11e-11 Lymphocyte percentage of white cells; CESC cis rs9925964 0.967 rs749767 chr16:31124407 C/T cg02466173 chr16:30829666 NA -0.32 -5.06 -0.3 7.68e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -8.31 -0.45 4.9e-15 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.909 rs73842633 chr4:120375464 G/A cg09307838 chr4:120376055 NA 0.92 12.08 0.6 4.68e-27 Corneal astigmatism; CESC cis rs1035144 0.785 rs4903962 chr14:81464486 A/G cg06600135 chr14:81408086 NA 0.38 5.2 0.3 4.06e-7 Male sexual orientation; CESC cis rs6831352 0.918 rs17218602 chr4:100061073 A/G cg12011299 chr4:100065546 ADH4 -0.59 -6.59 -0.38 2.35e-10 Alcohol dependence; CESC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg11890956 chr21:40555474 PSMG1 -0.97 -15.94 -0.7 1.46e-40 Cognitive function; CESC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.15 0.3 4.99e-7 Menopause (age at onset); CESC trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21659725 chr3:3221576 CRBN 0.83 13.42 0.64 1.11e-31 Intelligence (multi-trait analysis); CESC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.04 10.28 0.53 4.33e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg11663144 chr21:46675770 NA -0.42 -5.57 -0.32 6.22e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg27125505 chr17:43679177 LOC644172 -0.49 -6.64 -0.38 1.73e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1707322 0.638 rs1707302 chr1:46600917 A/G cg03146154 chr1:46216737 IPP -0.58 -7.02 -0.4 1.87e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2249625 0.545 rs2496505 chr6:72891063 C/G cg18830697 chr6:72922368 RIMS1 -0.46 -6.92 -0.39 3.35e-11 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs1348850 0.608 rs2364845 chr2:178226240 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.76 10.83 0.55 7.38e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg24110177 chr3:50126178 RBM5 0.53 7.37 0.41 2.2e-12 Intelligence (multi-trait analysis); CESC cis rs10791097 0.720 rs6590517 chr11:130733505 C/T cg12179176 chr11:130786555 SNX19 0.61 9.15 0.49 1.59e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg18305652 chr10:134549665 INPP5A 0.48 6.75 0.38 9.22e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs4911259 0.507 rs8118663 chr20:31398876 A/G cg13636640 chr20:31349939 DNMT3B 0.45 5.49 0.32 9.36e-8 Inflammatory bowel disease; CESC cis rs2463822 1.000 rs951677 chr11:62107249 G/C cg06239285 chr11:62104954 ASRGL1 0.97 8.71 0.47 3.45e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs722599 0.683 rs7145246 chr14:75242394 A/T cg08847533 chr14:75593920 NEK9 -0.49 -6.03 -0.35 5.43e-9 IgG glycosylation; CESC cis rs8180040 0.966 rs11710322 chr3:47331136 C/T cg27129171 chr3:47204927 SETD2 -0.66 -10.07 -0.53 2.14e-20 Colorectal cancer; CESC cis rs6598955 0.671 rs11247905 chr1:26627907 G/C cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.45 0.32 1.18e-7 Obesity-related traits; CESC cis rs3820068 0.705 rs59502343 chr1:15872617 T/C cg18192808 chr1:15853278 DNAJC16 0.46 5.63 0.33 4.49e-8 Systolic blood pressure; CESC cis rs7589342 0.507 rs6543338 chr2:106403911 C/G cg16077055 chr2:106428750 NCK2 0.37 5.4 0.32 1.46e-7 Addiction; CESC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg19626725 chr5:178986131 RUFY1 0.41 6.61 0.38 2.12e-10 Lung cancer; CESC cis rs754466 1.000 rs12220902 chr10:79682918 C/T cg17075019 chr10:79541650 NA -0.7 -8.97 -0.48 5.56e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2832191 0.740 rs2832168 chr21:30463695 G/A cg08807101 chr21:30365312 RNF160 0.92 13.62 0.64 2.27e-32 Dental caries; CESC cis rs35146811 0.586 rs12705067 chr7:99594726 T/C cg14163444 chr7:99595348 NA -0.4 -5.34 -0.31 1.98e-7 Coronary artery disease; CESC cis rs9486715 0.867 rs3849199 chr6:97049191 T/C cg18709589 chr6:96969512 KIAA0776 -0.45 -6.21 -0.36 2.05e-9 Headache; CESC cis rs1348850 0.567 rs3770011 chr2:178537890 C/T cg22681709 chr2:178499509 PDE11A -0.49 -7.22 -0.41 5.66e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2228479 0.850 rs2238531 chr16:89856217 C/G cg14709524 chr16:89940631 TCF25 0.94 7.06 0.4 1.5e-11 Skin colour saturation; CESC cis rs4474465 0.850 rs4590904 chr11:78263847 C/T cg27205649 chr11:78285834 NARS2 0.43 5.5 0.32 8.94e-8 Alzheimer's disease (survival time); CESC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg16145915 chr7:1198662 ZFAND2A -0.61 -9.25 -0.49 7.84e-18 Longevity;Endometriosis; CESC cis rs11122272 0.735 rs2790880 chr1:231534259 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -6.53 -0.37 3.31e-10 Hemoglobin concentration; CESC cis rs4253772 0.575 rs9615979 chr22:46789021 G/T cg18190219 chr22:46762943 CELSR1 -0.69 -6.01 -0.35 6.24e-9 LDL cholesterol;Cholesterol, total; CESC cis rs9916302 0.904 rs2338800 chr17:37498149 C/G cg15445000 chr17:37608096 MED1 -0.41 -6.83 -0.39 5.65e-11 Glomerular filtration rate (creatinine); CESC cis rs5771242 0.776 rs6010198 chr22:50610628 A/G cg16473166 chr22:50639996 SELO -0.75 -8.95 -0.48 6.56e-17 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg12379764 chr21:47803548 PCNT 0.47 6.04 0.35 5.07e-9 Testicular germ cell tumor; CESC trans rs7839040 0.698 rs13258597 chr8:82923733 A/G cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs10170846 0.861 rs6740452 chr2:223518452 C/T cg25565276 chr2:223520875 FARSB 0.5 6.97 0.39 2.5e-11 Schizophrenia (inflammation and infection response interaction); CESC cis rs1395 0.634 rs72817542 chr2:27526681 C/G cg22903471 chr2:27725779 GCKR -0.5 -6.05 -0.35 5.04e-9 Blood metabolite levels; CESC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.33e-10 Skin colour saturation; CESC cis rs4253772 0.678 rs1053332 chr22:46640179 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 6.74 0.38 9.67e-11 LDL cholesterol;Cholesterol, total; CESC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg12034118 chr1:209979487 IRF6 0.51 6.17 0.35 2.61e-9 Cleft lip with or without cleft palate; CESC cis rs710216 0.957 rs3738514 chr1:43426591 A/G cg03128534 chr1:43423976 SLC2A1 -0.54 -6.25 -0.36 1.64e-9 Red cell distribution width; CESC cis rs3862030 0.668 rs12781718 chr10:104227433 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.37 -5.17 -0.3 4.71e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg19774624 chr17:42201019 HDAC5 0.52 6.93 0.39 3.26e-11 Total body bone mineral density; CESC cis rs6732160 0.564 rs60796597 chr2:73382914 C/T cg01422370 chr2:73384389 NA 0.57 8.95 0.48 6.19e-17 Intelligence (multi-trait analysis); CESC cis rs12497850 1.000 rs4858828 chr3:48724811 C/T cg06212747 chr3:49208901 KLHDC8B 0.61 8.26 0.45 7.08e-15 Parkinson's disease; CESC trans rs7618501 0.966 rs13085679 chr3:49869631 G/A cg21659725 chr3:3221576 CRBN 0.82 13.26 0.63 4e-31 Intelligence (multi-trait analysis); CESC cis rs2742234 0.590 rs2115817 chr10:43686552 C/T cg07801480 chr10:43725741 RASGEF1A 0.41 5.29 0.31 2.56e-7 Hirschsprung disease; CESC cis rs1801251 0.893 rs6733151 chr2:233592341 A/C cg08000102 chr2:233561755 GIGYF2 0.69 9.75 0.51 2.22e-19 Coronary artery disease; CESC cis rs7178572 0.568 rs11632966 chr15:77621805 A/C cg22256960 chr15:77711686 NA -0.54 -6.86 -0.39 4.9e-11 Type 2 diabetes; CESC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs4906332 1.000 rs12879663 chr14:103874215 A/G cg09975044 chr14:104007538 NA 0.43 5.91 0.34 1.07e-8 Coronary artery disease; CESC cis rs9486715 0.867 rs2223238 chr6:96871855 G/A cg06623918 chr6:96969491 KIAA0776 0.9 13.69 0.64 1.26e-32 Headache; CESC cis rs9815354 0.638 rs56194645 chr3:41843593 T/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.67 0.33 3.7e-8 Electroencephalogram traits; CESC cis rs425277 1.000 rs1401138 chr1:2063149 C/T cg16545954 chr1:2118288 C1orf86 0.34 5.65 0.33 4.15e-8 Height; CESC cis rs13385 0.769 rs10079286 chr5:139599134 G/A cg26211634 chr5:139558579 C5orf32 0.47 5.19 0.3 4.12e-7 Atrial fibrillation; CESC trans rs1814175 0.817 rs12277258 chr11:49940216 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -21.21 -0.79 4.77e-59 Height; CESC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg21724239 chr8:58056113 NA 0.6 5.45 0.32 1.17e-7 Developmental language disorder (linguistic errors); CESC cis rs2073300 1.000 rs6137962 chr20:23443966 T/C cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs698833 0.624 rs2166453 chr2:44693424 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.4 -5.08 -0.3 7.16e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11839334 chr14:21152763 RNASE4;ANG -0.58 -6.52 -0.37 3.49e-10 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16083082 chr10:51371691 LOC728407;PARG 0.45 6.46 0.37 4.92e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs9951602 0.512 rs12454617 chr18:76656007 C/T cg02800362 chr5:177631904 HNRNPAB 0.65 8.51 0.46 1.31e-15 Obesity-related traits; CESC cis rs61931739 0.782 rs3903201 chr12:34248275 G/A cg19457237 chr12:34500585 NA -0.42 -5.72 -0.33 2.86e-8 Morning vs. evening chronotype; CESC cis rs1144713 0.531 rs1716941 chr12:32255094 A/G cg01321189 chr12:32259338 BICD1 0.43 5.67 0.33 3.7e-8 Obesity-related traits; CESC cis rs9291683 0.517 rs11736479 chr4:10017387 G/C cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.51e-12 Bone mineral density; CESC cis rs2236918 0.932 rs1776131 chr1:242024245 T/A cg17736920 chr1:242011382 EXO1 0.71 9.03 0.49 3.53e-17 Menopause (age at onset); CESC cis rs3796352 1.000 rs7622420 chr3:53111069 A/G cg26060971 chr3:52407402 DNAH1 -0.42 -5.06 -0.3 7.98e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg20573242 chr4:122745356 CCNA2 0.65 8.05 0.44 2.81e-14 Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10989441 chr1:231347308 TRIM67 -0.43 -6.1 -0.35 3.7e-9 Gambling; CESC trans rs60843830 1.000 rs62114497 chr2:214837 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 7.8 0.43 1.44e-13 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1355223 1.000 rs11607300 chr11:34759319 C/T cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.08 -0.35 4.16e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs861020 0.563 rs35898529 chr1:210053096 G/A cg05527609 chr1:210001259 C1orf107 -0.99 -10.87 -0.56 5.24e-23 Orofacial clefts; CESC cis rs8005677 0.770 rs56180741 chr14:23377246 T/C cg01529538 chr14:23388837 RBM23 0.43 5.95 0.34 8.44e-9 Cognitive ability (multi-trait analysis); CESC cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg24110177 chr3:50126178 RBM5 -0.51 -7.09 -0.4 1.19e-11 Intelligence (multi-trait analysis); CESC cis rs2742234 1.000 rs2742234 chr10:43612609 A/G cg15436174 chr10:43711423 RASGEF1A 0.41 5.26 0.31 3.01e-7 Hirschsprung disease; CESC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg08109568 chr15:31115862 NA -0.67 -8.66 -0.47 4.55e-16 Huntington's disease progression; CESC cis rs11077998 0.933 rs3736204 chr17:80530279 C/T cg10255544 chr17:80519551 FOXK2 0.55 8.73 0.47 2.83e-16 Reticulocyte fraction of red cells; CESC cis rs9549367 0.789 rs9549716 chr13:113908478 G/A cg18105134 chr13:113819100 PROZ -0.68 -8.71 -0.47 3.37e-16 Platelet distribution width; CESC cis rs4654899 0.758 rs6690574 chr1:21504279 G/A cg05370193 chr1:21551575 ECE1 0.39 6.04 0.35 5.15e-9 Superior frontal gyrus grey matter volume; CESC cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg02297831 chr4:17616191 MED28 0.5 6.07 0.35 4.52e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4555082 0.874 rs4677 chr14:105717279 T/C cg27165867 chr14:105738592 BRF1 -0.54 -6.08 -0.35 4.18e-9 Mean platelet volume;Platelet distribution width; CESC cis rs992157 0.560 rs1514132 chr2:219084082 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.57 -7.39 -0.41 1.96e-12 Colorectal cancer; CESC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg08109568 chr15:31115862 NA -0.72 -9.73 -0.51 2.44e-19 Huntington's disease progression; CESC cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg00745463 chr17:30367425 LRRC37B -0.8 -7.25 -0.41 4.55e-12 Hip circumference adjusted for BMI; CESC cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.05 10.33 0.54 2.97e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11690935 0.959 rs7597387 chr2:172577116 T/C cg13550731 chr2:172543902 DYNC1I2 -1.0 -16.26 -0.71 1.08e-41 Schizophrenia; CESC cis rs12971120 0.891 rs11151961 chr18:72177340 C/T cg26446133 chr18:72167187 CNDP2 -0.74 -9.14 -0.49 1.69e-17 Refractive error; CESC cis rs2797160 1.000 rs2211418 chr6:125995503 G/A cg05901451 chr6:126070800 HEY2 -0.46 -6.67 -0.38 1.52e-10 Endometrial cancer; CESC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg05564831 chr3:52568323 NT5DC2 0.46 6.93 0.39 3.15e-11 Bipolar disorder; CESC cis rs1499972 0.590 rs62264775 chr3:117648002 A/C cg07612923 chr3:117604196 NA 0.7 6.33 0.36 1.02e-9 Schizophrenia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07545714 chr3:122135128 WDR5B -0.57 -7.32 -0.41 3e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg26939375 chr7:64535504 NA 0.48 6.17 0.35 2.57e-9 Aortic root size; CESC cis rs13040088 1.000 rs6090155 chr20:61527378 G/A cg23096297 chr20:61557774 DIDO1 0.96 10.68 0.55 2.3e-22 Menopause (age at onset); CESC cis rs1953600 0.870 rs2788295 chr10:81941007 C/G cg00277334 chr10:82204260 NA 0.45 6.28 0.36 1.39e-9 Sarcoidosis; CESC cis rs11098499 0.754 rs10213267 chr4:120239074 A/G cg09307838 chr4:120376055 NA 0.79 10.77 0.55 1.17e-22 Corneal astigmatism; CESC cis rs2290720 0.930 rs1379486 chr12:101699347 T/C cg22051763 chr12:101673672 UTP20 -0.45 -5.68 -0.33 3.59e-8 Brain structure (hippocampal volume); CESC cis rs34172651 0.571 rs9922156 chr16:24704329 C/A cg04756594 chr16:24857601 SLC5A11 -0.53 -6.85 -0.39 5.11e-11 Intelligence (multi-trait analysis); CESC trans rs3942852 0.774 rs10838814 chr11:48187178 G/A cg03929089 chr4:120376271 NA -0.65 -7.1 -0.4 1.15e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs7223966 1.000 rs55868506 chr17:61851686 T/G cg11494091 chr17:61959527 GH2 0.38 5.18 0.3 4.33e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7202877 0.706 rs247450 chr16:75490017 C/A cg04384234 chr16:75411784 CFDP1 0.48 5.41 0.32 1.44e-7 Type 2 diabetes;Type 1 diabetes; CESC cis rs7542091 0.704 rs7550330 chr1:210044587 G/A cg09509183 chr1:209979624 IRF6 0.4 5.78 0.33 2.12e-8 Monobrow; CESC cis rs3806843 0.676 rs2569159 chr5:140030710 C/T cg16179182 chr5:140090404 VTRNA1-1 0.4 5.08 0.3 7.23e-7 Depressive symptoms (multi-trait analysis); CESC trans rs11098499 0.754 rs12510269 chr4:120241646 A/G cg25214090 chr10:38739885 LOC399744 0.61 8.46 0.46 1.86e-15 Corneal astigmatism; CESC cis rs763121 0.853 rs2179142 chr22:39037954 G/A cg14440974 chr22:39074834 NA -0.37 -5.09 -0.3 6.66e-7 Menopause (age at onset); CESC cis rs7259376 0.869 rs11673228 chr19:22596084 G/A cg02657401 chr19:22469223 NA 0.26 5.14 0.3 5.46e-7 Menopause (age at onset); CESC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg04518342 chr5:131593106 PDLIM4 -0.35 -5.06 -0.3 7.79e-7 Breast cancer; CESC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg25036284 chr2:26402008 FAM59B -0.59 -6.88 -0.39 4.37e-11 Gut microbiome composition (summer); CESC cis rs2985684 1.000 rs2985697 chr14:50092902 A/G cg02151108 chr14:50098012 C14orf104 -0.45 -5.9 -0.34 1.09e-8 Carotid intima media thickness; CESC cis rs9308433 0.529 rs10465697 chr1:214499948 T/C cg06198575 chr1:214491504 SMYD2 0.5 6.0 0.35 6.37e-9 IgG glycosylation; CESC cis rs7829975 0.742 rs882462 chr8:8678530 G/A cg15556689 chr8:8085844 FLJ10661 0.45 5.69 0.33 3.29e-8 Mood instability; CESC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.84 9.11 0.49 2.05e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 9.9 0.52 7.02e-20 Prudent dietary pattern; CESC cis rs55794721 0.509 rs2982358 chr1:25745204 G/T cg03538708 chr1:25844672 NA -0.4 -6.06 -0.35 4.59e-9 Plateletcrit;Mean corpuscular volume; CESC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg10691866 chr7:65817282 TPST1 0.32 5.42 0.32 1.35e-7 Aortic root size; CESC cis rs7312933 0.558 rs7965743 chr12:42736822 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.49 -6.46 -0.37 5.02e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC trans rs116095464 0.558 rs9688045 chr5:254035 T/C cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.35e-11 Breast cancer; CESC cis rs2651899 0.865 rs2817126 chr1:3083246 T/G cg07622451 chr1:3079886 PRDM16 0.29 5.22 0.31 3.55e-7 Migraine; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21813473 chr20:40247231 CHD6 -0.42 -6.02 -0.35 5.68e-9 Gut microbiota (bacterial taxa); CESC cis rs208346 0.612 rs208356 chr7:2775825 A/T cg18446336 chr7:2847575 GNA12 0.43 6.98 0.39 2.3e-11 Loneliness (linear analysis); CESC cis rs9612 0.948 rs12609587 chr19:44268654 T/C cg08581076 chr19:44259116 C19orf61 0.49 5.76 0.33 2.35e-8 Exhaled nitric oxide output; CESC cis rs920590 0.876 rs3907477 chr8:19657744 C/T cg03894339 chr8:19674705 INTS10 0.54 6.42 0.37 6.28e-10 Acute lymphoblastic leukemia (childhood); CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg12623088 chr15:66585521 DIS3L 0.54 6.04 0.35 5.17e-9 Endometrial cancer; CESC cis rs9911578 0.967 rs57869245 chr17:57106630 A/G cg05425664 chr17:57184151 TRIM37 0.51 7.08 0.4 1.26e-11 Intelligence (multi-trait analysis); CESC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.15e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs5753618 0.561 rs2283881 chr22:31638932 G/A cg13145458 chr22:31556086 RNF185 0.46 5.21 0.3 3.86e-7 Colorectal cancer; CESC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg22903657 chr4:1355424 KIAA1530 -0.38 -5.18 -0.3 4.5e-7 Obesity-related traits; CESC cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg20476274 chr7:133979776 SLC35B4 0.69 10.23 0.53 6.29e-21 Mean platelet volume; CESC cis rs7520050 0.966 rs785495 chr1:46587887 A/G cg24296786 chr1:45957014 TESK2 0.42 5.32 0.31 2.23e-7 Red blood cell count;Reticulocyte count; CESC cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg12756686 chr19:29218302 NA 0.58 7.52 0.42 8.38e-13 Methadone dose in opioid dependence; CESC cis rs2573652 0.723 rs2573655 chr15:100515709 A/C cg09918751 chr15:100517450 ADAMTS17 -0.45 -9.02 -0.48 3.92e-17 Height; CESC cis rs1034435 0.755 rs5768681 chr22:48894501 C/T cg05992904 chr22:48892994 FAM19A5 -0.57 -9.76 -0.51 2e-19 Late-onset Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04018571 chr2:96874059 STARD7 0.59 7.02 0.4 1.91e-11 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18632102 chr5:154238496 CNOT8 0.5 6.7 0.38 1.22e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs722599 0.683 rs11848876 chr14:75224626 C/G cg08847533 chr14:75593920 NEK9 0.49 6.0 0.35 6.52e-9 IgG glycosylation; CESC cis rs2011503 0.891 rs2965186 chr19:19497195 T/G cg11584989 chr19:19387371 SF4 -0.63 -7.42 -0.41 1.63e-12 Bipolar disorder; CESC cis rs6540556 0.723 rs9430012 chr1:209900615 G/C cg05527609 chr1:210001259 C1orf107 -0.66 -7.35 -0.41 2.44e-12 Red blood cell count; CESC cis rs3008870 1.000 rs1925411 chr1:67370292 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.01 13.55 0.64 3.74e-32 Lymphocyte percentage of white cells; CESC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg03240473 chr21:43526662 UMODL1;C21orf128 -0.42 -5.28 -0.31 2.73e-7 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18816107 chr1:151227233 PSMD4 0.57 6.27 0.36 1.49e-9 Gut microbiome composition (summer); CESC cis rs861020 0.630 rs585627 chr1:210004199 C/G cg05527609 chr1:210001259 C1orf107 0.74 9.67 0.51 3.97e-19 Orofacial clefts; CESC cis rs111756027 0.593 rs11862987 chr16:77247504 C/T cg01504555 chr16:77246968 SYCE1L 0.58 5.44 0.32 1.18e-7 Bone mineral density (Ward's triangle area); CESC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg04025307 chr7:1156635 C7orf50 0.43 7.0 0.39 2.11e-11 Longevity;Endometriosis; CESC cis rs826838 0.967 rs2892410 chr12:38990282 A/G cg13010199 chr12:38710504 ALG10B -0.6 -8.59 -0.47 7.43e-16 Heart rate; CESC cis rs2235544 0.664 rs41366847 chr1:54476967 C/G cg09175620 chr1:54484536 LDLRAD1 -0.29 -5.09 -0.3 6.88e-7 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11412256 chr1:228612818 HIST3H3 0.5 6.73 0.38 1.04e-10 Fibrinogen levels; CESC cis rs8017423 0.933 rs7150378 chr14:90724566 G/A cg14092571 chr14:90743983 NA -0.55 -8.41 -0.46 2.56e-15 Mortality in heart failure; CESC cis rs698833 0.886 rs4953091 chr2:44565266 A/C cg18685995 chr2:44588913 PREPL;C2orf34 -0.53 -6.9 -0.39 3.88e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7949030 0.653 rs2849030 chr11:62366986 G/A cg13298116 chr11:62369859 EML3;MTA2 -0.62 -9.14 -0.49 1.64e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2228479 0.702 rs62053701 chr16:89860584 G/A cg19635926 chr16:89946313 TCF25 0.68 5.17 0.3 4.65e-7 Skin colour saturation; CESC cis rs870825 0.655 rs2017101 chr4:185637381 G/A cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs10876993 0.893 rs3825078 chr12:58089413 A/T cg18357645 chr12:58087776 OS9 0.64 10.62 0.55 3.61e-22 Celiac disease or Rheumatoid arthritis; CESC trans rs4714598 1.000 rs4714598 chr6:42282393 A/G cg23980859 chr1:55844285 NA 0.36 6.01 0.35 6.22e-9 Eosinophil percentage of white cells; CESC trans rs9325144 0.671 rs7306605 chr12:38730471 C/T cg23762105 chr12:34175262 ALG10 -0.48 -6.36 -0.36 8.87e-10 Morning vs. evening chronotype; CESC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg18099408 chr3:52552593 STAB1 -0.3 -5.07 -0.3 7.59e-7 Electroencephalogram traits; CESC cis rs2228479 0.850 rs2238525 chr16:89809902 T/C cg04287289 chr16:89883240 FANCA 0.7 6.04 0.35 5.3300000000000004e-09 Skin colour saturation; CESC cis rs1003719 0.788 rs1543750 chr21:38446918 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.7 0.47 3.48e-16 Eye color traits; CESC cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg05347473 chr6:146136440 FBXO30 -0.72 -9.17 -0.49 1.4e-17 Lobe attachment (rater-scored or self-reported); CESC cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg25517755 chr10:38738941 LOC399744 -0.46 -5.98 -0.34 7.15e-9 Extrinsic epigenetic age acceleration; CESC cis rs412050 0.696 rs113366054 chr22:22267184 A/C cg17089214 chr22:22089827 YPEL1 0.73 6.02 0.35 5.9e-9 Attention deficit hyperactivity disorder; CESC trans rs9951418 0.559 rs72968934 chr18:73853667 A/G cg00711132 chr7:87506492 DBF4;SLC25A40 -0.6 -6.0 -0.35 6.38e-9 Interleukin-10 levels; CESC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg21770322 chr7:97807741 LMTK2 0.57 8.84 0.48 1.39e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs2732480 0.577 rs2634678 chr12:48735538 C/G cg04545296 chr12:48745243 ZNF641 0.43 7.15 0.4 8.63e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2486288 0.656 rs2413771 chr15:45553140 A/G cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.51 -0.37 3.85e-10 Glomerular filtration rate; CESC cis rs997295 0.554 rs28568344 chr15:68096527 A/G cg08079166 chr15:68083412 MAP2K5 0.4 6.39 0.37 7.62e-10 Motion sickness; CESC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg16606324 chr3:10149918 C3orf24 0.43 5.22 0.31 3.71e-7 Alzheimer's disease; CESC cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.07 0.3 7.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9522267 0.511 rs1163626 chr13:112225200 A/C cg10483660 chr13:112241077 NA -0.32 -5.67 -0.33 3.71e-8 Hepatitis; CESC trans rs801193 0.967 rs2420827 chr7:66147101 G/A cg26939375 chr7:64535504 NA -0.6 -7.89 -0.44 8.14e-14 Aortic root size; CESC cis rs3106136 1.000 rs2632401 chr4:95147055 C/G cg11021082 chr4:95130006 SMARCAD1 0.49 7.58 0.42 5.77e-13 Capecitabine sensitivity; CESC cis rs5753037 0.640 rs131260 chr22:30132964 A/C cg01021169 chr22:30184971 ASCC2 -0.47 -6.61 -0.38 2.08e-10 Type 1 diabetes; CESC cis rs2243480 1.000 rs781149 chr7:65481284 C/T cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs929354 0.772 rs1182444 chr7:157024510 A/G cg05182265 chr7:156933206 UBE3C 0.52 7.56 0.42 6.76e-13 Body mass index; CESC cis rs9303401 0.625 rs10515159 chr17:56802693 G/C cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24371536 chr6:79943342 HMGN3 -0.57 -8.37 -0.46 3.38e-15 Gambling; CESC cis rs2882667 0.822 rs11738376 chr5:138398172 G/A cg04439458 chr5:138467593 SIL1 -0.37 -5.81 -0.34 1.78e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs1008375 0.933 rs4698637 chr4:17632843 A/T cg02297831 chr4:17616191 MED28 0.56 6.9 0.39 3.84e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.35 -5.64 -0.33 4.29e-8 Hip circumference adjusted for BMI; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07931792 chr19:12707809 ZNF490 0.55 7.26 0.41 4.23e-12 Fibrinogen levels; CESC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg17650747 chr5:1873721 NA 0.45 6.22 0.36 1.95e-9 Cardiovascular disease risk factors; CESC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg27535305 chr1:53392650 SCP2 0.3 5.34 0.31 2.03e-7 Monocyte count; CESC cis rs12142240 0.698 rs17361936 chr1:46862893 C/T cg00530320 chr1:46809349 NSUN4 0.6 8.17 0.45 1.25e-14 Menopause (age at onset); CESC cis rs2456568 0.548 rs10466335 chr11:93663820 G/C cg26875233 chr11:93583750 C11orf90 -0.32 -5.79 -0.34 1.95e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs11214589 0.651 rs11214596 chr11:113264511 C/G cg14159747 chr11:113255604 NA 0.36 6.37 0.36 8.16e-10 Neuroticism; CESC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg04772025 chr11:68637568 NA -0.48 -5.89 -0.34 1.19e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg11905131 chr22:24372483 LOC391322 -0.7 -9.99 -0.52 3.8e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg18446336 chr7:2847575 GNA12 -0.4 -6.02 -0.35 5.92e-9 Height; CESC cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg24308560 chr3:49941425 MST1R -0.61 -8.81 -0.48 1.63e-16 Intelligence (multi-trait analysis); CESC cis rs6460942 0.591 rs10262667 chr7:12385391 C/T cg02935154 chr7:12443704 VWDE -0.45 -6.01 -0.35 6.15e-9 Coronary artery disease; CESC cis rs11098499 0.955 rs11944880 chr4:120159334 A/G cg24375607 chr4:120327624 NA -0.44 -5.29 -0.31 2.5e-7 Corneal astigmatism; CESC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.69e-9 Total body bone mineral density; CESC cis rs2243480 1.000 rs1392104 chr7:65759107 G/A cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC cis rs9811920 0.665 rs1872609 chr3:99906579 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.36 -5.51 -0.32 8.43e-8 Axial length; CESC cis rs28374715 0.532 rs11854820 chr15:41676526 G/A cg18705301 chr15:41695430 NDUFAF1 -1.08 -17.72 -0.74 7.19e-47 Ulcerative colitis; CESC cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg20503657 chr10:835505 NA 0.78 7.72 0.43 2.41e-13 Eosinophil percentage of granulocytes; CESC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.7 -8.29 -0.45 5.67e-15 Alzheimer's disease; CESC cis rs7927592 0.956 rs12281742 chr11:68303629 C/T cg01657329 chr11:68192670 LRP5 0.39 5.13 0.3 5.6e-7 Total body bone mineral density; CESC cis rs2832077 0.527 rs9981922 chr21:30212718 A/G cg24692254 chr21:30365293 RNF160 -0.64 -8.66 -0.47 4.77e-16 Cognitive test performance; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13830646 chr11:65668067 FOSL1 -0.41 -6.14 -0.35 2.98e-9 Fibrinogen levels; CESC cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg06544989 chr22:39130855 UNC84B 0.5 8.75 0.47 2.49e-16 Menopause (age at onset); CESC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg06074448 chr4:187884817 NA -0.48 -7.37 -0.41 2.15e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11963202 chr7:98985799 ARPC1B -0.6 -7.26 -0.41 4.38e-12 Gut microbiome composition (summer); CESC cis rs8060686 0.545 rs17688076 chr16:68286427 C/A cg26727032 chr16:67993705 SLC12A4 -0.52 -5.58 -0.32 5.79e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs9911578 0.839 rs7208505 chr17:57187729 C/T cg12560992 chr17:57184187 TRIM37 0.98 17.15 0.73 7.51e-45 Intelligence (multi-trait analysis); CESC cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg06636001 chr8:8085503 FLJ10661 -0.5 -6.56 -0.37 2.88e-10 Mood instability; CESC trans rs875971 0.964 rs2161065 chr7:65932905 A/G cg26939375 chr7:64535504 NA 0.47 6.09 0.35 4.06e-9 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20306180 chr22:32340197 C22orf24;YWHAH -0.69 -8.81 -0.48 1.73e-16 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs116095464 0.558 rs6555056 chr5:226222 T/C cg22857025 chr5:266934 NA -1.27 -18.8 -0.76 1.13e-50 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10088075 chr16:30407103 ZNF48 0.57 6.15 0.35 2.85e-9 Gut microbiome composition (summer); CESC cis rs3540 0.597 rs10152221 chr15:91047664 A/G cg10434728 chr15:90938212 IQGAP1 -0.43 -7.79 -0.43 1.53e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs6439153 0.933 rs1871951 chr3:128720487 A/G cg25356066 chr3:128598488 ACAD9 0.54 7.0 0.4 2.1e-11 Pneumococcal bacteremia; CESC cis rs10744422 1.000 rs897386 chr12:123341289 A/C cg22842854 chr12:123319900 HIP1R -0.63 -5.26 -0.31 3e-7 Schizophrenia; CESC cis rs763014 0.898 rs62030902 chr16:638264 C/G cg07343612 chr16:622815 PIGQ -0.5 -6.83 -0.39 5.66e-11 Height; CESC cis rs9910055 0.512 rs7209801 chr17:42323376 G/A cg13607699 chr17:42295918 UBTF 0.85 12.21 0.6 1.73e-27 Total body bone mineral density; CESC cis rs1707322 1.000 rs1707322 chr1:46505147 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.64 0.33 4.44e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3845702 1.000 rs10497555 chr2:180864967 A/G cg01881094 chr2:180872142 CWC22 0.62 6.43 0.37 6.05e-10 Schizophrenia; CESC cis rs6088580 0.634 rs6059892 chr20:33105766 A/G cg06115741 chr20:33292138 TP53INP2 0.45 5.8 0.34 1.88e-8 Glomerular filtration rate (creatinine); CESC cis rs2204008 0.902 rs11520218 chr12:38223227 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.35e-10 Bladder cancer; CESC cis rs7100689 0.577 rs873395 chr10:82037215 C/T cg09936400 chr10:82049201 MAT1A -0.41 -5.96 -0.34 8.22e-9 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11967563 chr10:3186147 PITRM1 -0.57 -6.42 -0.37 6.13e-10 Gut microbiome composition (summer); CESC cis rs7824557 0.564 rs4631424 chr8:11236809 T/C cg21775007 chr8:11205619 TDH -0.54 -8.07 -0.44 2.52e-14 Retinal vascular caliber; CESC trans rs11098499 1.000 rs58601355 chr4:120186367 T/C cg25214090 chr10:38739885 LOC399744 0.63 8.32 0.46 4.54e-15 Corneal astigmatism; CESC cis rs11621710 0.557 rs799474 chr14:35516099 C/G cg16230307 chr14:35515116 FAM177A1 0.57 7.31 0.41 3.2e-12 Granulocyte percentage of myeloid white cells; CESC cis rs9814567 0.896 rs6799110 chr3:134206749 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -6.08 -0.35 4.26e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg18252515 chr7:66147081 NA 0.48 6.43 0.37 5.77e-10 Aortic root size; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg05564831 chr3:52568323 NT5DC2 0.51 8.59 0.47 7.82e-16 Hemoglobin concentration; CESC cis rs3733585 0.605 rs7656624 chr4:10121097 T/C cg11266682 chr4:10021025 SLC2A9 -0.57 -10.97 -0.56 2.54e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11871801 0.517 rs60929812 chr17:40759448 G/A cg21433558 chr17:40837037 CNTNAP1 0.48 5.84 0.34 1.56e-8 Crohn's disease; CESC cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg04972856 chr6:88032051 C6orf162;GJB7 0.33 5.29 0.31 2.54e-7 Monocyte percentage of white cells; CESC cis rs11098499 0.661 rs10015965 chr4:120268237 A/G cg09307838 chr4:120376055 NA 0.76 10.0 0.52 3.52e-20 Corneal astigmatism; CESC cis rs3818285 0.556 rs2084607 chr10:111681411 C/T cg00817464 chr10:111662876 XPNPEP1 0.52 7.6 0.42 5.26e-13 Superior crus of antihelix expression; CESC cis rs1461503 0.932 rs7107575 chr11:122845406 C/T cg27398637 chr11:122830231 C11orf63 0.53 7.69 0.43 2.85e-13 Menarche (age at onset); CESC cis rs854765 0.547 rs7223696 chr17:17915791 G/T cg04398451 chr17:18023971 MYO15A -0.69 -10.29 -0.53 4.08e-21 Total body bone mineral density; CESC cis rs5769765 0.526 rs5770722 chr22:50253220 G/C cg02269571 chr22:50332266 NA 0.46 5.45 0.32 1.16e-7 Schizophrenia; CESC cis rs6842047 1.000 rs10471184 chr4:187122904 C/T cg02012338 chr4:187126139 CYP4V2 -0.73 -5.84 -0.34 1.53e-8 Blood protein levels; CESC cis rs6815814 0.898 rs17582830 chr4:38867427 A/G cg02016764 chr4:38805732 TLR1 -0.59 -7.22 -0.41 5.38e-12 Breast cancer; CESC cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg12365402 chr11:9010492 NRIP3 -0.31 -5.1 -0.3 6.41e-7 Hemoglobin concentration; CESC cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg03060546 chr3:49711283 APEH 0.51 6.07 0.35 4.49e-9 Parkinson's disease; CESC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg19592336 chr6:28129416 ZNF389 0.47 6.96 0.39 2.68e-11 Cardiac Troponin-T levels; CESC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg24531977 chr5:56204891 C5orf35 -0.43 -5.36 -0.31 1.78e-7 Coronary artery disease; CESC cis rs9611565 0.659 rs11090049 chr22:41915329 C/T cg06481639 chr22:41940642 POLR3H -0.64 -6.55 -0.37 3.02e-10 Vitiligo; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg26210255 chr12:100594894 ACTR6 0.46 6.39 0.37 7.3e-10 Neuroticism; CESC trans rs208515 0.556 rs12214562 chr6:66681011 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 11.12 0.56 7.77e-24 Exhaled nitric oxide levels; CESC cis rs6582630 0.502 rs11520278 chr12:38359642 T/A cg26384229 chr12:38710491 ALG10B 0.73 10.65 0.55 2.87e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg16850897 chr7:100343110 ZAN -0.57 -6.14 -0.35 2.93e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3820068 0.705 rs4646092 chr1:15821673 C/T cg17385448 chr1:15911702 AGMAT 0.39 6.18 0.35 2.44e-9 Systolic blood pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21587861 chr12:32260103 BICD1 -0.44 -6.31 -0.36 1.16e-9 Gambling; CESC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg05564831 chr3:52568323 NT5DC2 0.45 7.03 0.4 1.72e-11 Electroencephalogram traits; CESC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg17427002 chr7:12443146 VWDE -0.53 -6.5 -0.37 3.91e-10 Coronary artery disease; CESC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg03352830 chr11:487213 PTDSS2 0.73 7.08 0.4 1.26e-11 Body mass index; CESC cis rs12497850 0.931 rs6442130 chr3:48778027 A/G cg06212747 chr3:49208901 KLHDC8B 0.57 7.03 0.4 1.74e-11 Parkinson's disease; CESC cis rs672059 0.513 rs627064 chr1:183165716 C/T cg23696949 chr1:183155644 LAMC2 -0.25 -5.82 -0.34 1.69e-8 Hypertriglyceridemia; CESC cis rs7078219 0.714 rs11190139 chr10:101288099 C/G cg09788492 chr10:101292477 NKX2-3 0.32 5.07 0.3 7.55e-7 Dental caries; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg15351736 chr11:111808104 DIXDC1 0.59 6.13 0.35 3.24e-9 Diastolic blood pressure; CESC trans rs709082 0.709 rs709097 chr3:191469255 T/C cg25305879 chr2:106814630 NA 0.4 6.46 0.37 5.04e-10 Colonoscopy-negative controls vs population controls; CESC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg18016565 chr1:150552671 MCL1 0.32 5.03 0.3 8.96e-7 Tonsillectomy; CESC cis rs12142240 0.698 rs10158572 chr1:46822440 G/T cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs589448 0.967 rs634512 chr12:69754012 C/T cg14784868 chr12:69753453 YEATS4 0.92 14.62 0.67 6.85e-36 Cerebrospinal fluid biomarker levels; CESC cis rs4076764 0.830 rs10917770 chr1:163442214 G/C cg06092702 chr1:163392909 NA -0.37 -5.43 -0.32 1.26e-7 Motion sickness; CESC cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg10523679 chr1:76189770 ACADM 0.63 6.09 0.35 4.06e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs763121 0.853 rs2205802 chr22:39046327 T/C cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC trans rs61931739 0.534 rs1826144 chr12:34094272 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.25 0.45 7.65e-15 Morning vs. evening chronotype; CESC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg16145915 chr7:1198662 ZFAND2A -0.49 -6.04 -0.35 5.1e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6831352 0.918 rs2851247 chr4:100046091 C/G cg13256891 chr4:100009986 ADH5 -0.82 -8.79 -0.47 1.98e-16 Alcohol dependence; CESC cis rs7605378 1.000 rs7605378 chr2:200676926 A/C cg23649088 chr2:200775458 C2orf69 0.5 6.45 0.37 5.39e-10 Osteoporosis; CESC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.65 0.38 1.71e-10 Prudent dietary pattern; CESC cis rs854765 0.655 rs4470201 chr17:17844870 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.17 0.45 1.3e-14 Total body bone mineral density; CESC cis rs2985684 0.894 rs4900927 chr14:50018741 G/T cg02151108 chr14:50098012 C14orf104 -0.38 -5.14 -0.3 5.35e-7 Carotid intima media thickness; CESC cis rs7208859 0.573 rs7222803 chr17:29119897 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4780401 0.703 rs3190321 chr16:11773662 C/G cg01061890 chr16:11836724 TXNDC11 -0.5 -6.75 -0.38 9.45e-11 Rheumatoid arthritis; CESC trans rs3942852 0.868 rs7118232 chr11:48106274 T/C cg15704280 chr7:45808275 SEPT13 -0.67 -7.65 -0.43 3.62e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg18305652 chr10:134549665 INPP5A 0.47 6.77 0.38 8.43e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg14393609 chr7:65229607 NA -0.42 -5.86 -0.34 1.34e-8 Aortic root size; CESC cis rs1881797 0.932 rs10925071 chr1:247686521 C/T cg11166453 chr1:247681781 NA -0.44 -6.33 -0.36 1.06e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs1577917 0.771 rs2842613 chr6:86305702 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.52 7.25 0.41 4.58e-12 Response to antipsychotic treatment; CESC cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg20225915 chr11:805726 LRDD 0.3 5.06 0.3 7.81e-7 Breast cancer; CESC cis rs67311347 1.000 rs7634375 chr3:40431946 C/T cg24209194 chr3:40518798 ZNF619 0.5 6.24 0.36 1.74e-9 Renal cell carcinoma; CESC cis rs4986811 1.000 rs11031779 chr11:32452888 C/T cg27409910 chr11:32454216 WT1 0.49 6.33 0.36 1.04e-9 Rubella-specific interleukin-6 secretion; CESC cis rs2806561 0.929 rs641452 chr1:23538386 A/G cg12483005 chr1:23474871 LUZP1 0.32 5.12 0.3 5.8e-7 Height; CESC cis rs1670533 1.000 rs2045066 chr4:1052401 C/T cg27284194 chr4:1044797 NA 0.45 5.75 0.33 2.43e-8 Recombination rate (females); CESC cis rs9303401 0.555 rs8073699 chr17:57236317 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.64 7.98 0.44 4.36e-14 Cognitive test performance; CESC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg18230493 chr5:56204884 C5orf35 -0.73 -8.57 -0.47 8.93e-16 Initial pursuit acceleration; CESC cis rs4964805 0.802 rs934847 chr12:104185693 C/T cg02344784 chr12:104178138 NT5DC3 0.39 5.42 0.32 1.31e-7 Attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18737971 chr15:43941642 CATSPER2 -0.74 -8.71 -0.47 3.45e-16 Gut microbiome composition (summer); CESC cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg26597838 chr10:835615 NA 0.83 9.05 0.49 3.21e-17 Eosinophil percentage of granulocytes; CESC cis rs10465746 0.967 rs11163874 chr1:84424437 G/C cg10977910 chr1:84465055 TTLL7 0.47 6.28 0.36 1.38e-9 Obesity-related traits; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg24337108 chr10:11797422 ECHDC3 -0.42 -6.07 -0.35 4.43e-9 Systemic lupus erythematosus; CESC cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg24130564 chr14:104152367 KLC1 -0.49 -6.46 -0.37 4.98e-10 Reticulocyte count; CESC cis rs34779708 0.966 rs12260130 chr10:35467671 C/T cg04310649 chr10:35416472 CREM -0.54 -6.78 -0.38 7.74e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs2760061 0.598 rs632832 chr1:228121838 G/T cg02753203 chr1:228287806 NA -0.5 -7.4 -0.41 1.75e-12 Diastolic blood pressure; CESC cis rs6662572 0.855 rs7517418 chr1:46252418 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.06 -0.3 7.79e-7 Blood protein levels; CESC cis rs7539624 0.588 rs61823966 chr1:223895942 C/T cg10100437 chr1:223903862 CAPN2 0.43 5.44 0.32 1.22e-7 Schizophrenia; CESC cis rs2072732 0.821 rs58052947 chr1:2950094 T/C cg15211996 chr1:2936768 ACTRT2 0.32 5.67 0.33 3.8e-8 Plateletcrit; CESC cis rs9549260 0.755 rs3892360 chr13:41184078 C/G cg21288729 chr13:41239152 FOXO1 0.64 8.31 0.45 4.98e-15 Red blood cell count; CESC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg13628971 chr7:2884303 GNA12 0.63 8.47 0.46 1.7e-15 Height; CESC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.59 0.32 5.76e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11229555 1.000 rs2298608 chr11:58404467 A/G cg15696309 chr11:58395628 NA 0.46 5.94 0.34 8.95e-9 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs6499255 0.951 rs57565297 chr16:69723122 G/T cg15192750 chr16:69999425 NA 0.5 5.73 0.33 2.67e-8 IgE levels; CESC trans rs4130047 0.606 rs8096948 chr18:40681293 T/C cg27079740 chr4:176733877 GPM6A 0.42 6.02 0.35 5.79e-9 Parkinson's disease; CESC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg18225595 chr11:63971243 STIP1 0.52 5.16 0.3 4.77e-7 Mean platelet volume; CESC cis rs4654899 0.865 rs6691824 chr1:21417577 T/G cg05370193 chr1:21551575 ECE1 0.43 6.73 0.38 1.07e-10 Superior frontal gyrus grey matter volume; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg01889112 chr15:59063272 FAM63B -0.53 -6.9 -0.39 3.82e-11 Ulcerative colitis; CESC cis rs7666738 0.830 rs1593573 chr4:98925293 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.898 rs8072297 chr17:37478048 A/T cg20243544 chr17:37824526 PNMT -0.45 -5.53 -0.32 7.78e-8 Glomerular filtration rate (creatinine); CESC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.49 0.32 9.35e-8 Parkinson's disease; CESC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg09658497 chr7:2847517 GNA12 -0.44 -6.14 -0.35 3.06e-9 Height; CESC cis rs7216064 0.765 rs6504550 chr17:65894542 A/G cg12091567 chr17:66097778 LOC651250 -0.65 -8.19 -0.45 1.14e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs13427251 0.868 rs1901284 chr2:100146040 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.51 6.73 0.38 1.07e-10 Chronic sinus infection; CESC cis rs13392177 0.660 rs10932762 chr2:219076213 G/C cg20019365 chr2:219134978 PNKD;AAMP -0.52 -6.43 -0.37 5.9e-10 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs10871290 1.000 rs10871290 chr16:74472696 C/T cg01733217 chr16:74700730 RFWD3 -0.65 -8.64 -0.47 5.55e-16 Breast cancer; CESC cis rs7772486 0.790 rs4280983 chr6:146280790 G/C cg23711669 chr6:146136114 FBXO30 -0.93 -13.53 -0.64 4.58e-32 Lobe attachment (rater-scored or self-reported); CESC cis rs5769765 0.908 rs9616396 chr22:50317825 T/C cg26441486 chr22:50317300 CRELD2 0.48 5.75 0.33 2.44e-8 Schizophrenia; CESC cis rs561341 0.528 rs11650908 chr17:30195425 T/C cg13647721 chr17:30228624 UTP6 -0.69 -8.22 -0.45 9.08e-15 Hip circumference adjusted for BMI; CESC cis rs1421811 0.532 rs17540044 chr5:32692238 C/G cg16267343 chr5:32710456 NPR3 -0.55 -6.06 -0.35 4.73e-9 Blood pressure; CESC cis rs3820928 0.874 rs2229812 chr2:227896886 C/T cg05526886 chr2:227700861 RHBDD1 -0.45 -5.65 -0.33 4.22e-8 Pulmonary function; CESC trans rs637571 0.522 rs566590 chr11:65754062 C/T cg17712092 chr4:129076599 LARP1B 0.72 9.89 0.52 7.93e-20 Eosinophil percentage of white cells; CESC cis rs7084402 0.967 rs1658490 chr10:60281616 G/A cg07615347 chr10:60278583 BICC1 -0.6 -9.49 -0.5 1.43e-18 Refractive error; CESC trans rs11098499 0.562 rs58583086 chr4:120556362 A/G cg25214090 chr10:38739885 LOC399744 -0.53 -7.68 -0.43 3.02e-13 Corneal astigmatism; CESC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg22800045 chr5:56110881 MAP3K1 0.59 7.76 0.43 1.86e-13 Initial pursuit acceleration; CESC cis rs10411936 0.712 rs9305079 chr19:16591464 C/T cg10248733 chr19:16607483 C19orf44;CALR3 0.58 7.25 0.41 4.6e-12 White blood cell count;Multiple sclerosis; CESC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg05340658 chr4:99064831 C4orf37 0.63 8.31 0.45 4.9e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2072499 0.750 rs7534339 chr1:156156219 A/G cg25208724 chr1:156163844 SLC25A44 0.99 12.47 0.61 2.09e-28 Testicular germ cell tumor; CESC cis rs2243480 1.000 rs778691 chr7:65873092 G/C cg12463550 chr7:65579703 CRCP 0.71 5.49 0.32 9.37e-8 Diabetic kidney disease; CESC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.6 -7.86 -0.43 9.62e-14 Prudent dietary pattern; CESC cis rs3806843 0.735 rs801168 chr5:140080298 A/G cg26395211 chr5:140044315 WDR55 0.49 6.25 0.36 1.67e-9 Depressive symptoms (multi-trait analysis); CESC cis rs6674176 0.660 rs3791112 chr1:44379248 T/G cg13606994 chr1:44402422 ARTN -0.41 -6.28 -0.36 1.37e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.95 0.34 8.58e-9 Tonsillectomy; CESC cis rs10927875 1.000 rs10927875 chr1:16299312 A/G cg22431228 chr1:16359049 CLCNKA -0.37 -5.82 -0.34 1.7e-8 Dilated cardiomyopathy; CESC cis rs4074961 0.669 rs6687545 chr1:38071195 C/T cg13401533 chr1:37979913 MEAF6 0.52 7.05 0.4 1.51e-11 Axial length; CESC trans rs208520 0.690 rs4710311 chr6:66823223 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.86 -11.54 -0.58 3.09e-25 Exhaled nitric oxide output; CESC cis rs3105593 0.933 rs4775894 chr15:50903600 C/T cg08437265 chr15:50716283 USP8 0.42 5.33 0.31 2.05e-7 QT interval; CESC cis rs12079745 0.793 rs11805562 chr1:169292916 A/C cg09363564 chr1:169337483 NME7;BLZF1 -1.13 -6.56 -0.37 2.81e-10 QT interval; CESC cis rs11690935 0.571 rs13020884 chr2:172901699 T/G cg13550731 chr2:172543902 DYNC1I2 0.46 6.1 0.35 3.68e-9 Schizophrenia; CESC cis rs7680126 0.633 rs11727390 chr4:10296760 C/T cg11266682 chr4:10021025 SLC2A9 -0.42 -5.66 -0.33 4.01e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg08499158 chr17:42289980 UBTF 0.5 6.34 0.36 1.01e-9 Total body bone mineral density; CESC cis rs4561483 0.583 rs33636 chr16:11990323 C/G cg08843971 chr16:11963173 GSPT1 -0.49 -6.93 -0.39 3.13e-11 Testicular germ cell tumor; CESC cis rs910316 0.763 rs6574205 chr14:75453039 G/C cg16144293 chr14:75469539 EIF2B2 -0.4 -5.23 -0.31 3.38e-7 Height; CESC cis rs2243480 1.000 rs781150 chr7:65480973 C/T cg18252515 chr7:66147081 NA -1.26 -12.38 -0.61 4.54e-28 Diabetic kidney disease; CESC cis rs3768617 0.510 rs3768615 chr1:183103604 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.5800000000000005e-35 Fuchs's corneal dystrophy; CESC cis rs4523957 0.757 rs1002135 chr17:2097583 T/G cg16513277 chr17:2031491 SMG6 -0.57 -7.84 -0.43 1.08e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4629710 0.538 rs11754401 chr6:131582197 G/A cg12606694 chr6:131520996 AKAP7 0.49 5.99 0.35 6.95e-9 Multiple myeloma (IgH translocation); CESC cis rs62244186 0.566 rs2135531 chr3:44881158 C/G cg15225532 chr3:44803084 KIF15;KIAA1143 0.41 5.36 0.31 1.85e-7 Depressive symptoms; CESC cis rs1215050 0.740 rs1084784 chr4:98961711 T/G cg17366294 chr4:99064904 C4orf37 -0.38 -5.03 -0.3 8.96e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs644799 1.000 rs693364 chr11:95621926 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.47 5.53 0.32 7.48e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg04944784 chr2:26401820 FAM59B 0.96 10.82 0.55 7.56e-23 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg08470875 chr2:26401718 FAM59B -0.47 -5.22 -0.31 3.6e-7 Gut microbiome composition (summer); CESC cis rs1163251 0.902 rs839605 chr1:120217524 C/A cg19096424 chr1:120255104 PHGDH 0.43 5.22 0.31 3.62e-7 Blood metabolite levels; CESC cis rs6580649 0.941 rs17122612 chr12:48459488 C/G cg24011408 chr12:48396354 COL2A1 -0.41 -5.3 -0.31 2.43e-7 Lung cancer; CESC cis rs977987 0.750 rs4888414 chr16:75447233 A/G cg03315344 chr16:75512273 CHST6 0.41 5.83 0.34 1.59e-8 Dupuytren's disease; CESC cis rs2415984 0.622 rs61993302 chr14:46949684 C/T cg14871534 chr14:47121158 RPL10L -0.38 -5.67 -0.33 3.72e-8 Number of children ever born; CESC cis rs17539620 0.624 rs12665520 chr6:154835273 C/T cg20019720 chr6:154832845 CNKSR3 0.44 5.91 0.34 1.03e-8 Lipoprotein (a) levels; CESC cis rs2204008 0.506 rs11495470 chr12:38026904 C/T cg26384229 chr12:38710491 ALG10B 0.66 9.39 0.5 2.96e-18 Bladder cancer; CESC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg24879335 chr3:133465180 TF 0.37 6.47 0.37 4.62e-10 Iron status biomarkers; CESC cis rs9388451 0.874 rs7739566 chr6:126094757 A/T cg10911889 chr6:126070802 HEY2 0.36 5.09 0.3 6.91e-7 Brugada syndrome; CESC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg06481639 chr22:41940642 POLR3H 0.68 7.26 0.41 4.43e-12 Vitiligo; CESC cis rs11252926 0.674 rs11598550 chr10:504778 A/C cg18196295 chr10:418757 DIP2C -0.52 -7.08 -0.4 1.33e-11 Psychosis in Alzheimer's disease; CESC cis rs7927771 0.542 rs11039336 chr11:47706141 A/G cg18512352 chr11:47633146 NA -0.36 -5.65 -0.33 4.17e-8 Subjective well-being; CESC cis rs10751667 1.000 rs10751667 chr11:941941 A/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.2 -0.3 4.04e-7 Alzheimer's disease (late onset); CESC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg13607699 chr17:42295918 UBTF 0.69 9.37 0.5 3.23e-18 Total body bone mineral density; CESC cis rs290268 0.874 rs772407 chr9:93560850 A/C cg02608019 chr9:93564028 SYK 0.67 10.22 0.53 6.84e-21 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15573879 chr1:36851774 STK40 -0.68 -8.15 -0.45 1.48e-14 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00634145 chr1:155108588 RAG1AP1 0.61 6.64 0.38 1.75e-10 Gut microbiome composition (summer); CESC cis rs3806843 1.000 rs10038174 chr5:140210616 G/A cg26395211 chr5:140044315 WDR55 -0.41 -5.05 -0.3 8.38e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9815354 0.951 rs1717028 chr3:41902964 C/T cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.46e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1153858 0.895 rs12593402 chr15:45617392 G/A cg14582100 chr15:45693742 SPATA5L1 0.4 5.62 0.33 4.8e-8 Homoarginine levels; CESC cis rs6460942 0.915 rs62448598 chr7:12453762 T/C cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg06028808 chr11:68637592 NA 0.48 5.71 0.33 3e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs76917914 0.820 rs7041811 chr9:100821028 C/T cg03040243 chr9:100819229 NANS 0.51 5.78 0.33 2.1e-8 Immature fraction of reticulocytes; CESC cis rs748404 0.697 rs493177 chr15:43543258 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.61 8.11 0.45 1.83e-14 Lung cancer; CESC cis rs10242455 0.702 rs78640327 chr7:99167139 G/C cg25640893 chr7:99214727 ZNF498 1.19 7.16 0.4 7.79e-12 Blood metabolite levels; CESC cis rs9584850 0.915 rs7983438 chr13:99103317 T/C cg20750642 chr13:99100586 FARP1 -0.38 -5.7 -0.33 3.23e-8 Neuroticism; CESC cis rs11030122 0.661 rs10767811 chr11:4066398 G/A cg18678763 chr11:4115507 RRM1 -0.44 -5.94 -0.34 8.74e-9 Mean platelet volume;Platelet distribution width; CESC cis rs72781680 0.898 rs72780188 chr2:24006065 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24829313 chr11:63684597 RCOR2 -0.45 -6.53 -0.37 3.31e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6542838 0.704 rs56125264 chr2:99516699 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.23 -0.31 3.43e-7 Fear of minor pain; CESC cis rs12682352 0.602 rs6988939 chr8:8666916 C/T cg06636001 chr8:8085503 FLJ10661 0.42 5.3 0.31 2.4e-7 Neuroticism; CESC cis rs2070488 1.000 rs2276540 chr3:38512507 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.95 17.45 0.73 6.36e-46 Electrocardiographic conduction measures; CESC cis rs66561647 0.719 rs4733582 chr8:128947967 C/T cg05480350 chr8:128972681 MIR1205;PVT1 0.4 5.34 0.31 1.98e-7 Hemoglobin concentration; CESC cis rs7617773 0.817 rs11709691 chr3:48303669 A/G cg11946769 chr3:48343235 NME6 0.86 11.61 0.58 1.78e-25 Coronary artery disease; CESC cis rs568617 0.626 rs10896050 chr11:65577516 G/T cg04055107 chr11:65626734 MUS81;CFL1 0.73 6.63 0.38 1.87e-10 Crohn's disease; CESC cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 8.98 0.48 5.33e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs3820068 0.705 rs72643683 chr1:15824905 C/A cg17385448 chr1:15911702 AGMAT 0.4 6.12 0.35 3.37e-9 Systolic blood pressure; CESC cis rs2228479 0.850 rs2286393 chr16:89809548 C/A cg06558623 chr16:89946397 TCF25 1.09 8.78 0.47 2e-16 Skin colour saturation; CESC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg21724239 chr8:58056113 NA 0.59 5.24 0.31 3.36e-7 Developmental language disorder (linguistic errors); CESC cis rs9470366 0.772 rs9918353 chr6:36622677 A/C cg08179530 chr6:36648295 CDKN1A 0.56 6.7 0.38 1.28e-10 QRS duration; CESC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg05863683 chr7:1912471 MAD1L1 0.44 6.51 0.37 3.79e-10 Bipolar disorder and schizophrenia; CESC cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg26874164 chr19:58962979 ZNF324B 0.53 7.17 0.4 7.42e-12 Uric acid clearance; CESC cis rs12220238 0.730 rs4746177 chr10:75913033 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.55 0.37 3.04e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg26314531 chr2:26401878 FAM59B -0.77 -8.56 -0.47 9.38e-16 Gut microbiome composition (summer); CESC cis rs765787 0.530 rs4442750 chr15:45535328 G/T cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs17428076 0.793 rs12622772 chr2:172625737 T/C cg13550731 chr2:172543902 DYNC1I2 0.46 5.16 0.3 4.9e-7 Myopia; CESC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.71 0.38 1.17e-10 Bipolar disorder; CESC cis rs8018808 1.000 rs4575469 chr14:77860543 G/A cg20045696 chr14:77926864 AHSA1 -0.38 -5.18 -0.3 4.46e-7 Myeloid white cell count; CESC cis rs4073221 0.520 rs66659472 chr3:18196527 G/A cg07694806 chr3:18168406 NA -0.67 -5.27 -0.31 2.79e-7 Parkinson's disease; CESC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg02931644 chr1:25747376 RHCE 0.47 7.99 0.44 4.14e-14 Erythrocyte sedimentation rate; CESC cis rs7520050 0.966 rs1085244 chr1:46563680 C/A cg03146154 chr1:46216737 IPP -0.43 -5.52 -0.32 8.27e-8 Red blood cell count;Reticulocyte count; CESC cis rs13394619 0.744 rs10929759 chr2:11722012 C/G cg07314298 chr2:11723111 GREB1 0.45 6.59 0.38 2.34e-10 Endometriosis; CESC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg06028808 chr11:68637592 NA -0.42 -5.13 -0.3 5.5e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg05535760 chr7:792225 HEATR2 -0.96 -11.08 -0.56 1.08e-23 Cerebrospinal P-tau181p levels; CESC cis rs11098499 0.954 rs10014845 chr4:120301077 T/G cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs6460942 0.915 rs62448619 chr7:12457743 C/T cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs11677416 1.000 rs6542091 chr2:113525311 G/A cg27083787 chr2:113543245 IL1A 0.41 5.16 0.3 4.75e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs847577 0.722 rs1013887 chr7:97709345 G/T cg24562669 chr7:97807699 LMTK2 0.61 9.8 0.52 1.52e-19 Breast cancer; CESC cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg02297831 chr4:17616191 MED28 0.62 7.91 0.44 7.23e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6691722 0.503 rs1064842 chr1:24706269 A/G cg18323236 chr1:24743029 NIPAL3 0.37 5.61 0.33 5.09e-8 Response to interferon beta in multiple sclerosis; CESC cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg04111992 chr7:158790115 NA -0.33 -5.22 -0.31 3.59e-7 Facial morphology (factor 20); CESC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Tonsillectomy; CESC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg07256732 chr16:621771 PIGQ -0.31 -5.36 -0.31 1.82e-7 Height; CESC cis rs72781680 0.898 rs79023848 chr2:24038174 C/A cg20701182 chr2:24300061 SF3B14 0.78 6.7 0.38 1.22e-10 Lymphocyte counts; CESC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg05564831 chr3:52568323 NT5DC2 0.44 6.69 0.38 1.33e-10 Bipolar disorder; CESC cis rs6964587 1.000 rs7797834 chr7:91743150 C/T cg17063962 chr7:91808500 NA -0.58 -7.95 -0.44 5.26e-14 Breast cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg05358183 chr16:85112625 KIAA0513 -0.47 -6.52 -0.37 3.46e-10 Systemic lupus erythematosus; CESC cis rs12348691 0.503 rs3021523 chr9:100616583 T/C cg13688889 chr9:100608707 NA -0.9 -13.65 -0.64 1.78e-32 Alopecia areata; CESC cis rs2832191 0.740 rs6516890 chr21:30476812 T/A cg24692254 chr21:30365293 RNF160 0.8 12.54 0.61 1.25e-28 Dental caries; CESC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg02891314 chr5:179741120 GFPT2 0.56 7.75 0.43 1.93e-13 Height; CESC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg17971929 chr21:40555470 PSMG1 -0.6 -8.06 -0.44 2.64e-14 Menarche (age at onset); CESC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg25072359 chr17:41440525 NA 0.45 6.04 0.35 5.14e-9 Menopause (age at onset); CESC cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.79 8.79 0.47 1.98e-16 Alzheimer's disease; CESC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg26839252 chr6:160211577 TCP1;MRPL18 0.44 5.03 0.3 9.06e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs4132509 0.744 rs6687181 chr1:243878518 C/T cg21452805 chr1:244014465 NA 0.56 6.47 0.37 4.66e-10 RR interval (heart rate); CESC cis rs796364 0.715 rs78988795 chr2:201095739 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.73 -5.11 -0.3 6.23e-7 Schizophrenia; CESC cis rs926938 0.563 rs360635 chr1:115420518 A/C cg12756093 chr1:115239321 AMPD1 0.45 6.06 0.35 4.72e-9 Autism; CESC cis rs1008375 0.898 rs61047804 chr4:17593965 G/A cg27347728 chr4:17578864 LAP3 0.44 5.24 0.31 3.33e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6987853 0.966 rs2923439 chr8:42429122 A/G cg09913449 chr8:42400586 C8orf40 0.41 6.46 0.37 4.86e-10 Mean corpuscular hemoglobin concentration; CESC cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg10523679 chr1:76189770 ACADM -0.65 -6.55 -0.37 3e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs12368653 0.651 rs2307097 chr12:58195801 T/C cg00677455 chr12:58241039 CTDSP2 -0.46 -5.84 -0.34 1.51e-8 Multiple sclerosis; CESC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg22920501 chr2:26401640 FAM59B 0.91 10.33 0.54 3.07e-21 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18085405 chr10:29779942 SVIL 0.46 6.13 0.35 3.21e-9 Fibrinogen levels; CESC cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg22834771 chr12:69754056 YEATS4 -0.47 -6.18 -0.36 2.35e-9 Blood protein levels; CESC cis rs17376456 0.877 rs10066791 chr5:93350255 G/T cg21475434 chr5:93447410 FAM172A 0.74 6.57 0.37 2.6e-10 Diabetic retinopathy; CESC trans rs1814175 0.791 rs11040513 chr11:49778153 G/C cg15704280 chr7:45808275 SEPT13 -1.02 -19.96 -0.77 1.02e-54 Height; CESC trans rs77808099 0.590 rs7519812 chr1:16024189 C/T cg06826283 chr7:600452 PRKAR1B 0.69 6.14 0.35 3e-9 Alcoholic chronic pancreatitis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26759515 chr16:67515027 ATP6V0D1 -0.45 -6.17 -0.35 2.6e-9 Fibrinogen levels; CESC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg25036284 chr2:26402008 FAM59B 0.74 7.85 0.43 1.01e-13 Gut microbiome composition (summer); CESC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg25405998 chr7:65216604 CCT6P1 -0.45 -5.79 -0.33 2.04e-8 Calcium levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01052087 chr20:10414899 C20orf94;MKKS 0.59 6.41 0.37 6.82e-10 Gut microbiome composition (summer); CESC trans rs561341 0.941 rs2428336 chr17:30290577 T/C cg20587970 chr11:113659929 NA -1.11 -13.49 -0.64 6.31e-32 Hip circumference adjusted for BMI; CESC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg27297192 chr10:134578999 INPP5A 0.4 5.13 0.3 5.54e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs66887589 0.616 rs7659403 chr4:120207254 T/A cg25214090 chr10:38739885 LOC399744 0.43 6.02 0.35 5.75e-9 Diastolic blood pressure; CESC cis rs4604732 0.642 rs7515859 chr1:247640057 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.46 6.5 0.37 3.87e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.71 0.38 1.14e-10 Prudent dietary pattern; CESC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg17372223 chr3:52568218 NT5DC2 0.43 6.46 0.37 5.02e-10 Bipolar disorder; CESC cis rs826838 0.967 rs1684411 chr12:39128494 C/T cg26384229 chr12:38710491 ALG10B -0.66 -10.31 -0.54 3.42e-21 Heart rate; CESC cis rs735396 0.595 rs1169279 chr12:121455873 C/T cg02403541 chr12:121454288 C12orf43 0.81 11.96 0.59 1.21e-26 N-glycan levels; CESC trans rs6601327 0.602 rs7829463 chr8:9649691 C/G cg15556689 chr8:8085844 FLJ10661 -0.51 -6.06 -0.35 4.71e-9 Multiple myeloma (hyperdiploidy); CESC cis rs9916302 0.861 rs8079590 chr17:37426201 T/C cg20243544 chr17:37824526 PNMT 0.46 5.76 0.33 2.31e-8 Glomerular filtration rate (creatinine); CESC cis rs3617 0.573 rs3821873 chr3:52913006 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.31 -5.29 -0.31 2.59e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs75477785 0.590 rs72649938 chr1:210208472 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.49 0.37 4.26e-10 Cleft lip with or without cleft palate; CESC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg04287289 chr16:89883240 FANCA 0.91 16.23 0.71 1.36e-41 Vitiligo; CESC cis rs1348850 0.958 rs1548067 chr2:178462914 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.78 0.47 2.13e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9902453 0.874 rs7213517 chr17:28401740 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -9.08 -0.49 2.59e-17 Coffee consumption (cups per day); CESC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg08470875 chr2:26401718 FAM59B -0.56 -6.35 -0.36 9.51e-10 Gut microbiome composition (summer); CESC cis rs11871801 0.560 rs8068844 chr17:40571284 T/C cg21433558 chr17:40837037 CNTNAP1 0.46 5.82 0.34 1.65e-8 Crohn's disease; CESC cis rs8141529 0.719 rs5762880 chr22:29287816 T/G cg02153584 chr22:29168773 CCDC117 0.59 7.62 0.42 4.46e-13 Lymphocyte counts; CESC cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg11502198 chr6:26597334 ABT1 0.52 5.34 0.31 1.99e-7 Intelligence (multi-trait analysis); CESC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg08859206 chr1:53392774 SCP2 0.54 6.88 0.39 4.27e-11 Monocyte count; CESC cis rs1707322 0.721 rs12069121 chr1:46231984 G/A cg06784218 chr1:46089804 CCDC17 0.41 7.19 0.4 6.5e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9906944 0.933 rs4794018 chr17:47093398 T/C cg09029085 chr17:47094198 IGF2BP1 0.26 5.16 0.3 4.82e-7 Intelligence (multi-trait analysis);Body fat percentage; CESC cis rs3749237 0.576 rs4241406 chr3:49600426 C/T cg07636037 chr3:49044803 WDR6 0.63 9.21 0.49 1.02e-17 Resting heart rate; CESC cis rs4664304 0.531 rs11691616 chr2:160758680 G/C cg03641300 chr2:160917029 PLA2R1 -0.39 -5.23 -0.31 3.51e-7 Crohn's disease;Inflammatory bowel disease; CESC cis rs818427 0.896 rs455412 chr5:112224389 G/T cg07820702 chr5:112228657 REEP5 -0.43 -5.36 -0.31 1.85e-7 Total body bone mineral density; CESC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.03e-11 Tonsillectomy; CESC trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg03929089 chr4:120376271 NA 0.79 11.81 0.59 3.94e-26 Coronary artery disease; CESC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg18876405 chr7:65276391 NA 0.52 7.03 0.4 1.8e-11 Aortic root size; CESC cis rs2243480 0.708 rs35310401 chr7:65390359 A/G cg18252515 chr7:66147081 NA -1.06 -9.79 -0.52 1.67e-19 Diabetic kidney disease; CESC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg09365446 chr1:150670422 GOLPH3L 0.42 5.9 0.34 1.09e-8 Tonsillectomy; CESC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg24733560 chr20:60626293 TAF4 0.41 5.79 0.34 2e-8 Body mass index; CESC cis rs477692 0.699 rs528549 chr10:131381574 A/G cg05714579 chr10:131428358 MGMT 0.42 5.52 0.32 7.9e-8 Response to temozolomide; CESC cis rs11098499 0.954 rs6838814 chr4:120392443 G/A cg09307838 chr4:120376055 NA 0.94 13.94 0.65 1.68e-33 Corneal astigmatism; CESC cis rs2073300 0.609 rs17757228 chr20:23351288 A/T cg12062639 chr20:23401060 NAPB 0.98 7.59 0.42 5.37e-13 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs910316 0.967 rs175498 chr14:75536369 G/A cg11812906 chr14:75593930 NEK9 -0.87 -14.67 -0.67 4.61e-36 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04769218 chr7:99098020 ZNF394 0.44 6.29 0.36 1.34e-9 Gut microbiota (bacterial taxa); CESC cis rs3768617 0.510 rs7542640 chr1:183063738 G/A ch.1.3577855R chr1:183094577 LAMC1 0.88 14.24 0.66 1.45e-34 Fuchs's corneal dystrophy; CESC cis rs2735413 0.918 rs1922621 chr16:78075015 A/G cg04733911 chr16:78082701 NA -0.53 -9.0 -0.48 4.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs2573652 1.000 rs2581343 chr15:100514418 C/G cg00587665 chr15:100533223 ADAMTS17 -0.41 -6.46 -0.37 4.99e-10 Height; CESC cis rs7598759 0.712 rs997400 chr2:232332847 C/T cg19187155 chr2:232395269 NMUR1 0.39 6.12 0.35 3.36e-9 Noise-induced hearing loss; CESC cis rs1784581 0.588 rs6455790 chr6:162418447 C/T cg17173639 chr6:162384350 PARK2 -0.57 -8.57 -0.47 8.94e-16 Itch intensity from mosquito bite; CESC cis rs8062405 0.965 rs7359397 chr16:28885659 C/T cg08761264 chr16:28874980 SH2B1 -0.45 -5.49 -0.32 9.61e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.38 5.04 0.3 8.73e-7 Menopause (age at onset); CESC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs2637266 1.000 rs2130798 chr10:78329563 C/T cg18941641 chr10:78392320 NA 0.42 7.93 0.44 6.17e-14 Pulmonary function; CESC cis rs5769765 0.862 rs138870 chr22:50209737 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.5 -5.52 -0.32 7.91e-8 Schizophrenia; CESC cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11102324 chr15:49658865 C15orf33 -0.58 -6.16 -0.35 2.69e-9 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs7214017 chr17:30332220 T/C cg12193833 chr17:30244370 NA -0.58 -5.95 -0.34 8.58e-9 Hip circumference adjusted for BMI; CESC cis rs13382862 0.823 rs12710743 chr2:20880714 T/C cg09074113 chr2:20870087 GDF7 -0.42 -6.7 -0.38 1.26e-10 Abdominal aortic aneurysm; CESC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg18016565 chr1:150552671 MCL1 0.34 5.28 0.31 2.67e-7 Tonsillectomy; CESC cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg05340658 chr4:99064831 C4orf37 0.78 11.64 0.58 1.43e-25 Colonoscopy-negative controls vs population controls; CESC cis rs55823223 0.648 rs936393 chr17:73847613 A/G cg10935138 chr17:73851978 WBP2 0.84 10.01 0.52 3.17e-20 Psoriasis; CESC cis rs2439831 0.850 rs8042868 chr15:43939642 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.71 7.45 0.42 1.36e-12 Lung cancer in ever smokers; CESC cis rs854765 0.619 rs1101727 chr17:18016148 T/C cg04398451 chr17:18023971 MYO15A -0.79 -11.56 -0.58 2.65e-25 Total body bone mineral density; CESC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg23978390 chr7:1156363 C7orf50 0.43 5.7 0.33 3.23e-8 Longevity;Endometriosis; CESC cis rs412050 0.547 rs76200689 chr22:22154644 G/A cg17089214 chr22:22089827 YPEL1 0.67 5.8 0.34 1.92e-8 Attention deficit hyperactivity disorder; CESC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.31 -5.05 -0.3 8.27e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs240764 0.764 rs13201976 chr6:100933185 T/A cg21058520 chr6:100914733 NA 0.4 6.24 0.36 1.7e-9 Neuroticism; CESC cis rs7772486 0.719 rs4391282 chr6:146276780 A/T cg23711669 chr6:146136114 FBXO30 -0.81 -11.35 -0.57 1.37e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs1348850 0.567 rs880897 chr2:178532503 C/T cg23306229 chr2:178417860 TTC30B 0.53 6.37 0.36 8.45e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9341808 0.718 rs2322630 chr6:80841033 A/G cg08355045 chr6:80787529 NA 0.34 5.46 0.32 1.07e-7 Sitting height ratio; CESC cis rs3741489 1.000 rs11147098 chr12:133406374 G/A cg01499426 chr12:133417423 CHFR 0.86 5.27 0.31 2.81e-7 Cognitive function; CESC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01391346 chr6:99873300 SFRS18 -0.55 -6.23 -0.36 1.83e-9 Gut microbiome composition (summer); CESC cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg24110177 chr3:50126178 RBM5 -0.54 -7.23 -0.41 5.19e-12 Intelligence (multi-trait analysis); CESC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg21984481 chr17:79567631 NPLOC4 0.49 8.04 0.44 2.97e-14 Eye color traits; CESC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs7586879 1.000 rs10175064 chr2:25117537 T/C cg01884057 chr2:25150051 NA 0.28 5.1 0.3 6.54e-7 Body mass index; CESC cis rs2439831 0.681 rs999047 chr15:43688916 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.53 0.54 7.06e-22 Lung cancer in ever smokers; CESC cis rs6582630 0.519 rs1851121 chr12:38389467 T/C cg26384229 chr12:38710491 ALG10B 0.73 11.08 0.56 1.07e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs2997447 0.761 rs112552200 chr1:26456947 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.41 0.32 1.44e-7 QRS complex (12-leadsum); CESC cis rs11696501 0.688 rs6065866 chr20:44323440 G/A cg11783356 chr20:44313418 WFDC10B -0.31 -5.08 -0.3 7.02e-7 Brain structure; CESC cis rs4332037 0.539 rs55790766 chr7:2021248 C/T cg23422044 chr7:1970798 MAD1L1 -0.5 -5.38 -0.31 1.61e-7 Bipolar disorder; CESC cis rs589448 0.902 rs315124 chr12:69771727 G/A cg14784868 chr12:69753453 YEATS4 0.89 14.22 0.66 1.68e-34 Cerebrospinal fluid biomarker levels; CESC cis rs9399135 0.967 rs45544135 chr6:135324051 T/C cg24558204 chr6:135376177 HBS1L 0.53 7.26 0.41 4.2e-12 Red blood cell count; CESC cis rs4727027 0.933 rs12154382 chr7:148862284 C/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.92 -0.39 3.45e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs1814175 0.645 rs11040535 chr11:49808669 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -6.04 -0.35 5.06e-9 Height; CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg16145915 chr7:1198662 ZFAND2A -0.77 -13.07 -0.63 1.81e-30 Longevity;Endometriosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23544526 chr7:66368779 NA 0.47 6.16 0.35 2.63e-9 Fibrinogen levels; CESC cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg23711669 chr6:146136114 FBXO30 -0.99 -14.22 -0.66 1.8e-34 Lobe attachment (rater-scored or self-reported); CESC trans rs1829883 0.739 rs1829882 chr5:98728778 G/A cg23861655 chr4:57411219 NA 0.39 6.43 0.37 6e-10 Hemostatic factors and hematological phenotypes; CESC cis rs6665290 0.669 rs3795445 chr1:227180947 A/C cg10327440 chr1:227177885 CDC42BPA -1.12 -24.88 -0.84 2.72e-71 Myeloid white cell count; CESC cis rs9291683 0.530 rs4697698 chr4:9942577 C/T cg11266682 chr4:10021025 SLC2A9 0.59 11.95 0.59 1.27e-26 Bone mineral density; CESC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg24818145 chr4:99064322 C4orf37 0.4 5.17 0.3 4.55e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.524 rs10838760 chr11:47786414 A/G cg20307385 chr11:47447363 PSMC3 0.61 8.59 0.47 7.41e-16 Subjective well-being; CESC cis rs6952809 0.532 rs2023969 chr7:2449980 T/C cg23289794 chr7:2394357 EIF3B -0.77 -6.98 -0.39 2.32e-11 Multiple sclerosis; CESC cis rs6456156 0.565 rs7750209 chr6:167482895 T/G cg23791538 chr6:167370224 RNASET2 -0.51 -6.44 -0.37 5.67e-10 Primary biliary cholangitis; CESC cis rs826838 1.000 rs826838 chr12:39106731 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.78 -0.33 2.06e-8 Heart rate; CESC trans rs11088226 0.846 rs2833884 chr21:33923075 A/G cg09050820 chr6:167586206 TCP10L2 0.63 6.56 0.37 2.74e-10 Gastritis; CESC cis rs478304 0.619 rs10791822 chr11:65428706 T/C cg27068330 chr11:65405492 SIPA1 -0.47 -5.33 -0.31 2.13e-7 Acne (severe); CESC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.48 -6.19 -0.36 2.33e-9 Tonsillectomy; CESC cis rs6831352 0.879 rs29001208 chr4:100052539 A/C cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs1595825 0.891 rs7592344 chr2:198572461 C/T cg00982548 chr2:198649783 BOLL -0.49 -5.21 -0.3 3.88e-7 Ulcerative colitis; CESC cis rs7210086 0.948 rs17780256 chr17:70642923 A/C cg04206342 chr17:70636940 NA -0.31 -5.46 -0.32 1.07e-7 Ulcerative colitis; CESC cis rs116095464 0.558 rs6866776 chr5:264495 C/T cg20965017 chr5:231967 SDHA -0.48 -5.43 -0.32 1.25e-7 Breast cancer; CESC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg24250549 chr1:154909240 PMVK 0.69 10.33 0.54 2.98e-21 Prostate cancer; CESC cis rs2456568 0.835 rs8181533 chr11:93638614 C/T cg26875233 chr11:93583750 C11orf90 -0.31 -5.4 -0.31 1.5e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs11098499 0.604 rs10022185 chr4:120571765 C/G cg24375607 chr4:120327624 NA 0.44 5.35 0.31 1.87e-7 Corneal astigmatism; CESC cis rs9486719 1.000 rs12214469 chr6:97019471 G/T cg06623918 chr6:96969491 KIAA0776 -0.8 -8.28 -0.45 6.29e-15 Migraine;Coronary artery disease; CESC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg07414643 chr4:187882934 NA -0.48 -6.56 -0.37 2.84e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs11711311 1.000 rs12637067 chr3:113527606 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.72 10.17 0.53 1.02e-20 IgG glycosylation; CESC cis rs853679 0.546 rs35744819 chr6:28318331 G/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 5.58 0.32 6.07e-8 Depression; CESC cis rs2708240 0.561 rs1723441 chr7:147549011 G/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.37 -5.74 -0.33 2.63e-8 QT interval (drug interaction); CESC cis rs2797160 1.000 rs6927161 chr6:126015954 T/C cg05901451 chr6:126070800 HEY2 0.46 6.55 0.37 2.89e-10 Endometrial cancer; CESC cis rs4234798 0.933 rs7678751 chr4:7219035 A/G cg18431297 chr4:7219810 SORCS2 0.43 7.39 0.41 1.9e-12 Insulin-like growth factors; CESC cis rs2180341 1.000 rs4897207 chr6:127605898 C/T cg27446573 chr6:127587934 RNF146 1.08 16.13 0.7 3.14e-41 Breast cancer; CESC cis rs2108622 0.727 rs55954696 chr19:15981805 A/G cg13772218 chr19:15982569 NA 0.3 5.99 0.35 6.85e-9 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs6812193 0.518 rs17001729 chr4:77188418 C/G cg20311846 chr4:77356250 SHROOM3 0.28 5.14 0.3 5.41e-7 Parkinson's disease; CESC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.4 0.31 1.51e-7 Menopause (age at onset); CESC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 6.74 0.38 1e-10 Personality dimensions; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10486909 chr13:46038825 COG3 -0.45 -6.04 -0.35 5.24e-9 Asthma; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26240433 chr14:94547826 DDX24;IFI27L1 -0.43 -6.02 -0.35 5.76e-9 Asthma; CESC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg12963246 chr6:28129442 ZNF389 0.58 7.55 0.42 7e-13 Depression; CESC cis rs2991971 0.729 rs10890328 chr1:45905383 G/T cg24296786 chr1:45957014 TESK2 -0.61 -8.67 -0.47 4.46e-16 High light scatter reticulocyte count; CESC cis rs9581857 0.685 rs10467687 chr13:28036516 G/A cg22138327 chr13:27999177 GTF3A 0.61 5.04 0.3 8.78e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs2066819 0.892 rs117305040 chr12:56657888 A/G cg26714650 chr12:56694279 CS -1.41 -9.99 -0.52 3.69e-20 Psoriasis vulgaris; CESC cis rs7267979 1.000 rs2387881 chr20:25378172 A/G cg08601574 chr20:25228251 PYGB -0.37 -5.4 -0.32 1.46e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg18252515 chr7:66147081 NA -0.43 -5.59 -0.32 5.73e-8 Aortic root size; CESC cis rs4704187 0.687 rs4703655 chr5:74455063 A/G cg03227963 chr5:74354835 NA 0.3 5.52 0.32 8.2e-8 Response to amphetamines; CESC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg21782813 chr7:2030301 MAD1L1 0.49 7.15 0.4 8.57e-12 Autism spectrum disorder or schizophrenia; CESC cis rs9814567 1.000 rs11708531 chr3:134224902 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.73 -0.33 2.73e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07604202 chr20:50701378 ZFP64 0.47 6.8 0.39 7.08e-11 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12997958 chr17:18161617 FLII -0.68 -7.35 -0.41 2.4e-12 Gut microbiome composition (summer); CESC cis rs2228479 0.702 rs62053701 chr16:89860584 G/A cg06558623 chr16:89946397 TCF25 1.18 9.47 0.5 1.65e-18 Skin colour saturation; CESC cis rs17401966 0.838 rs1556916 chr1:10403482 G/A cg15208524 chr1:10270712 KIF1B 0.4 5.12 0.3 5.76e-7 Hepatocellular carcinoma; CESC cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg05340658 chr4:99064831 C4orf37 0.79 12.28 0.6 9.45e-28 Colonoscopy-negative controls vs population controls; CESC cis rs1267303 0.675 rs2476164 chr1:46985274 T/C cg25110126 chr1:46999211 NA -0.71 -8.85 -0.48 1.31e-16 Monobrow; CESC cis rs3741151 0.773 rs113465107 chr11:73210416 T/G cg17517138 chr11:73019481 ARHGEF17 0.98 7.25 0.41 4.61e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7945705 0.967 rs7123861 chr11:8892323 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.36 5.85 0.34 1.48e-8 Hemoglobin concentration; CESC cis rs2732480 0.577 rs2634684 chr12:48730875 C/T cg04545296 chr12:48745243 ZNF641 -0.45 -7.45 -0.42 1.32e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs12477438 0.798 rs896886 chr2:99652713 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 10.66 0.55 2.68e-22 Chronic sinus infection; CESC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg06456125 chr7:65229604 NA -0.39 -5.09 -0.3 6.82e-7 Aortic root size; CESC cis rs11583043 0.918 rs6675403 chr1:101418569 T/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.54 6.06 0.35 4.57e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs8038465 0.662 rs57771618 chr15:73967578 T/C cg15420318 chr15:73925796 NPTN 0.52 7.84 0.43 1.07e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7107174 0.786 rs4945262 chr11:77990831 T/C cg02023728 chr11:77925099 USP35 0.47 6.25 0.36 1.6e-9 Testicular germ cell tumor; CESC cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg05585544 chr11:47624801 NA -0.48 -7.01 -0.4 2.01e-11 Subjective well-being; CESC cis rs2072732 0.808 rs74048148 chr1:2954031 A/G cg03976712 chr1:2946727 NA 0.33 5.51 0.32 8.63e-8 Plateletcrit; CESC cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg11752832 chr7:134001865 SLC35B4 0.53 6.92 0.39 3.47e-11 Mean platelet volume; CESC trans rs3780486 0.541 rs10738909 chr9:33148834 T/C cg20290983 chr6:43655470 MRPS18A 0.73 11.44 0.57 6.87e-25 IgG glycosylation; CESC cis rs1062177 1.000 rs2964612 chr5:151198750 G/A cg12924095 chr5:151150029 G3BP1 0.5 6.43 0.37 5.92e-10 Preschool internalizing problems; CESC cis rs2635047 0.967 rs2668786 chr18:44708472 A/G cg19077165 chr18:44547161 KATNAL2 -0.43 -5.83 -0.34 1.6e-8 Educational attainment; CESC cis rs769267 0.631 rs7252981 chr19:19692579 T/C cg03709012 chr19:19516395 GATAD2A -0.64 -7.92 -0.44 6.38e-14 Tonsillectomy; CESC cis rs11031096 0.678 rs12292724 chr11:4176671 T/A cg18678763 chr11:4115507 RRM1 -0.42 -5.81 -0.34 1.83e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12857652 chr6:64289969 PTP4A1 0.47 6.49 0.37 4.19e-10 Fibrinogen levels; CESC cis rs7666738 0.819 rs62318904 chr4:99036101 A/T cg17366294 chr4:99064904 C4orf37 0.62 8.62 0.47 6.05e-16 Colonoscopy-negative controls vs population controls; CESC cis rs8070740 1.000 rs8080400 chr17:5328633 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.54 6.53 0.37 3.32e-10 Menopause (age at onset); CESC cis rs1448094 0.511 rs4897823 chr12:86161484 C/T cg02569458 chr12:86230093 RASSF9 0.47 7.39 0.41 1.88e-12 Major depressive disorder; CESC cis rs17253792 0.731 rs79483151 chr14:56048851 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.85 5.74 0.33 2.53e-8 Putamen volume; CESC cis rs7408868 1.000 rs7247906 chr19:15271135 T/G cg14696996 chr19:15285081 NOTCH3 1.11 11.47 0.58 5.57e-25 Pulse pressure; CESC cis rs7927592 0.763 rs7129248 chr11:68263276 A/T cg01657329 chr11:68192670 LRP5 -0.46 -6.12 -0.35 3.31e-9 Total body bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09755102 chr1:33283495 S100PBP;YARS -0.44 -6.47 -0.37 4.78e-10 Gambling; CESC cis rs9303401 0.659 rs62083362 chr17:56846464 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.68 0.61 4.11e-29 Cognitive test performance; CESC cis rs1005277 0.522 rs1208684 chr10:38093936 G/A cg00409905 chr10:38381863 ZNF37A -0.5 -6.97 -0.39 2.53e-11 Extrinsic epigenetic age acceleration; CESC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg27170947 chr2:26402098 FAM59B -0.88 -11.12 -0.56 7.95e-24 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg17366294 chr4:99064904 C4orf37 0.62 8.86 0.48 1.22e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 0.524 rs11039377 chr11:47789776 C/T cg18512352 chr11:47633146 NA 0.34 5.24 0.31 3.35e-7 Subjective well-being; CESC cis rs3091242 0.933 rs9438905 chr1:25764177 A/G cg03538708 chr1:25844672 NA -0.4 -5.93 -0.34 9.53e-9 Erythrocyte sedimentation rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19636311 chr20:16710621 SNRPB2 0.6 6.76 0.38 8.95e-11 Gut microbiome composition (summer); CESC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.33 0.31 2.07e-7 Cognitive function; CESC cis rs15676 0.783 rs2977998 chr9:131580570 A/G cg00228799 chr9:131580591 ENDOG 0.54 7.01 0.4 1.97e-11 Blood metabolite levels; CESC cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg21918786 chr6:109611834 NA -0.35 -5.03 -0.3 8.9e-7 Reticulocyte fraction of red cells; CESC cis rs7116495 0.609 rs4945392 chr11:71694645 C/T cg26138937 chr11:71823887 C11orf51 -1.26 -8.07 -0.44 2.43e-14 Severe influenza A (H1N1) infection; CESC cis rs13102973 0.614 rs56199725 chr4:135873448 T/C cg14419869 chr4:135874104 NA -0.36 -5.36 -0.31 1.77e-7 Subjective well-being; CESC trans rs1545843 0.593 rs58319517 chr12:84795836 C/T cg03015433 chr16:56623111 MT3 -0.34 -6.12 -0.35 3.37e-9 Major depressive disorder; CESC cis rs11098499 0.754 rs4443261 chr4:120249301 T/C cg09307838 chr4:120376055 NA 0.77 10.35 0.54 2.54e-21 Corneal astigmatism; CESC cis rs34779708 0.931 rs17591135 chr10:35465190 T/A cg03585969 chr10:35415529 CREM 0.78 10.34 0.54 2.76e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.83 9.61 0.51 6.16e-19 Platelet count; CESC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg14159672 chr1:205819179 PM20D1 0.48 6.94 0.39 2.92e-11 Menarche (age at onset); CESC cis rs6066835 1.000 rs6125428 chr20:47292823 C/G cg18078177 chr20:47281410 PREX1 0.72 5.1 0.3 6.38e-7 Multiple myeloma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16557308 chr1:52082719 OSBPL9 0.53 6.04 0.35 5.07e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.3e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.865 rs56193110 chr17:80151501 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.42 -0.37 6.19e-10 Life satisfaction; CESC cis rs10751667 0.666 rs7395488 chr11:954111 T/C cg06064525 chr11:970664 AP2A2 -0.48 -9.52 -0.5 1.15e-18 Alzheimer's disease (late onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17760058 chr19:2321626 LSM7 0.41 6.01 0.35 6.23e-9 Fibrinogen levels; CESC cis rs10927875 0.518 rs945416 chr1:16344402 G/A cg22431228 chr1:16359049 CLCNKA -0.52 -10.02 -0.52 3.09e-20 Dilated cardiomyopathy; CESC cis rs11864453 0.713 rs7190995 chr16:72124157 A/G cg16558253 chr16:72132732 DHX38 -0.56 -8.7 -0.47 3.62e-16 Fibrinogen levels; CESC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg25838465 chr1:92012736 NA -0.62 -9.62 -0.51 5.45e-19 Breast cancer; CESC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg13393036 chr8:95962371 TP53INP1 -0.43 -9.01 -0.48 4.33e-17 Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08204369 chr17:73150733 HN1 -0.41 -6.05 -0.35 4.91e-9 Gambling; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07996345 chr11:47600851 KBTBD4;NDUFS3 -0.47 -6.71 -0.38 1.15e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg13393036 chr8:95962371 TP53INP1 -0.49 -10.46 -0.54 1.17e-21 Type 2 diabetes; CESC cis rs796364 0.662 rs11688415 chr2:201143409 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.75 5.76 0.33 2.27e-8 Schizophrenia; CESC cis rs9811920 0.638 rs793461 chr3:99615758 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04127825 chr1:167503222 NA 0.46 6.0 0.35 6.52e-9 Gut microbiota (bacterial taxa); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27180880 chr18:74844787 MBP -0.46 -6.07 -0.35 4.47e-9 Fibrinogen levels; CESC cis rs1372520 0.684 rs2619341 chr4:90741773 A/G cg15133208 chr4:90757351 SNCA -0.38 -5.09 -0.3 6.69e-7 Neuroticism; CESC cis rs9611565 0.765 rs202663 chr22:41812819 T/C cg03806693 chr22:41940476 POLR3H 1.05 12.35 0.6 5.55e-28 Vitiligo; CESC cis rs919433 0.783 rs3097383 chr2:198236887 A/G cg10820045 chr2:198174542 NA 0.41 5.93 0.34 9.6e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg23034840 chr1:205782522 SLC41A1 0.66 7.85 0.43 1.04e-13 Menarche (age at onset); CESC cis rs2832191 0.671 rs2832212 chr21:30511417 G/A cg08807101 chr21:30365312 RNF160 -0.54 -6.29 -0.36 1.33e-9 Dental caries; CESC trans rs945270 0.512 rs1953353 chr14:56189751 A/G cg18102697 chr4:83542773 C4orf11 0.41 6.21 0.36 2e-9 Subcortical brain region volumes; CESC cis rs1707322 1.000 rs6429588 chr1:46454058 T/G cg06784218 chr1:46089804 CCDC17 0.33 5.67 0.33 3.8e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11039798 0.557 rs4436575 chr11:48398894 T/C cg15704280 chr7:45808275 SEPT13 -0.69 -6.75 -0.38 9.03e-11 Axial length; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02949969 chr10:43048471 ZNF37B 0.45 6.27 0.36 1.45e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7089973 0.604 rs7915943 chr10:116618077 G/A cg25233709 chr10:116636983 FAM160B1 0.39 6.12 0.35 3.34e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00404177 chr1:51425685 FAF1 0.56 6.5 0.37 4.01e-10 Gut microbiome composition (summer); CESC cis rs1005277 0.522 rs289643 chr10:37941494 T/G cg25517755 chr10:38738941 LOC399744 -0.4 -5.11 -0.3 6.17e-7 Extrinsic epigenetic age acceleration; CESC cis rs79349575 0.783 rs62078372 chr17:47028989 T/C cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg18156793 chr20:32031936 SNTA1 -0.48 -6.46 -0.37 4.93e-10 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04761648 chr13:26829199 CDK8 0.47 6.12 0.35 3.27e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1008375 1.000 rs10805357 chr4:17652352 G/A cg15017067 chr4:17643749 FAM184B 0.35 5.07 0.3 7.59e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12618769 0.597 rs3769723 chr2:99105988 A/G cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs9291683 0.546 rs4575994 chr4:9997979 G/A cg11266682 chr4:10021025 SLC2A9 0.65 12.18 0.6 2.21e-27 Bone mineral density; CESC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg03452623 chr4:187889614 NA -0.86 -15.23 -0.68 4.57e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs7107174 1.000 rs10793304 chr11:78064907 A/G cg02023728 chr11:77925099 USP35 0.39 5.46 0.32 1.08e-7 Testicular germ cell tumor; CESC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg11987759 chr7:65425863 GUSB -0.46 -6.26 -0.36 1.54e-9 Aortic root size; CESC cis rs4237845 0.537 rs10747786 chr12:58260601 G/T cg00677455 chr12:58241039 CTDSP2 0.77 10.18 0.53 9.07e-21 Intelligence (multi-trait analysis); CESC cis rs9905704 0.918 rs2611779 chr17:56791832 A/G cg12560992 chr17:57184187 TRIM37 0.6 7.09 0.4 1.18e-11 Testicular germ cell tumor; CESC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg12463550 chr7:65579703 CRCP 0.5 6.3 0.36 1.21e-9 Aortic root size; CESC cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg14416269 chr4:6271139 WFS1 0.46 7.45 0.42 1.35e-12 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1153858 1.000 rs4775895 chr15:45617957 T/A cg21132104 chr15:45694354 SPATA5L1 0.84 11.12 0.56 8.16e-24 Homoarginine levels; CESC cis rs34779708 0.931 rs11010077 chr10:35328088 C/T cg03585969 chr10:35415529 CREM -0.75 -10.21 -0.53 7.43e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs2302190 1.000 rs8065388 chr17:56562132 C/T cg25885038 chr17:56607967 SEPT4 -0.4 -5.54 -0.32 7.29e-8 Vitamin D levels; CESC cis rs9916302 0.904 rs8068427 chr17:37511517 G/A cg15445000 chr17:37608096 MED1 -0.41 -6.6 -0.38 2.18e-10 Glomerular filtration rate (creatinine); CESC trans rs629535 0.590 rs55988608 chr8:70133619 A/G cg21567404 chr3:27674614 NA -0.86 -9.47 -0.5 1.63e-18 Dupuytren's disease; CESC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg12463550 chr7:65579703 CRCP 0.51 6.47 0.37 4.66e-10 Aortic root size; CESC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg04287289 chr16:89883240 FANCA -0.46 -5.85 -0.34 1.47e-8 Vitiligo; CESC cis rs7520050 0.807 rs4468203 chr1:46113272 T/C cg06784218 chr1:46089804 CCDC17 0.33 5.95 0.34 8.33e-9 Red blood cell count;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13884470 chr9:86595151 HNRNPK;RMI1 0.58 6.59 0.38 2.41e-10 Gut microbiome composition (summer); CESC cis rs4589502 0.502 rs2169460 chr15:67197240 A/G cg09911534 chr15:67153556 NA 0.37 5.35 0.31 1.95e-7 Lung cancer (smoking interaction); CESC cis rs258892 0.895 rs7737643 chr5:72058445 G/T cg21869765 chr5:72125136 TNPO1 -0.43 -5.37 -0.31 1.76e-7 Small cell lung carcinoma; CESC cis rs13191362 0.507 rs1954810 chr6:163061749 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -6.83 -0.39 5.63e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3782089 1.000 rs11600543 chr11:65298939 G/A cg21890820 chr11:65308645 LTBP3 1.14 8.54 0.46 1.05e-15 Height; CESC cis rs3820068 0.603 rs10492986 chr1:15988702 T/C cg18133145 chr1:16060689 PLEKHM2 -0.4 -5.11 -0.3 6.28e-7 Systolic blood pressure; CESC trans rs2727020 0.635 rs7124266 chr11:49280857 T/G cg03929089 chr4:120376271 NA 0.74 9.46 0.5 1.7e-18 Coronary artery disease; CESC trans rs3198697 0.617 rs11075253 chr16:15148646 C/A cg04146151 chr16:2155961 PKD1 -0.57 -6.31 -0.36 1.14e-9 Triglycerides; CESC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg17376030 chr22:41985996 PMM1 0.79 8.35 0.46 3.87e-15 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07936931 chr19:21933455 LOC641367;ZNF100 0.45 6.17 0.35 2.59e-9 Fibrinogen levels; CESC cis rs1580019 0.844 rs1376290 chr7:32486922 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.88 12.35 0.6 5.7e-28 Cognitive ability; CESC trans rs7819412 0.715 rs35223712 chr8:11043926 C/T cg06636001 chr8:8085503 FLJ10661 -0.6 -7.63 -0.42 4.32e-13 Triglycerides; CESC cis rs12618769 0.625 rs72821955 chr2:99159792 G/A cg10123293 chr2:99228465 UNC50 0.4 5.21 0.31 3.73e-7 Bipolar disorder; CESC cis rs796364 0.806 rs34582889 chr2:201010527 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.64 -6.04 -0.35 5.26e-9 Schizophrenia; CESC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg06221963 chr1:154839813 KCNN3 -0.66 -11.32 -0.57 1.71e-24 Prostate cancer; CESC cis rs6565180 0.962 rs35480350 chr16:30366039 G/A cg17640201 chr16:30407289 ZNF48 -0.93 -13.57 -0.64 3.44e-32 Tonsillectomy; CESC cis rs10838687 1.000 rs10838687 chr11:47312892 T/G cg25783544 chr11:47291846 MADD 0.6 7.45 0.42 1.3e-12 Proinsulin levels; CESC cis rs1364705 1.000 rs13281087 chr8:120224470 T/C cg09273054 chr8:120220131 MAL2 0.62 6.96 0.39 2.6e-11 Hippocampal atrophy; CESC cis rs8072100 0.713 rs1912486 chr17:45515167 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -5.43 -0.32 1.26e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1728785 0.901 rs1170444 chr16:68573287 T/C cg02972257 chr16:68554789 NA -0.55 -6.34 -0.36 9.7e-10 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00078194 chr11:46402949 MDK 0.58 7.11 0.4 1.09e-11 Gut microbiome composition (summer); CESC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg04756594 chr16:24857601 SLC5A11 0.5 5.66 0.33 4.02e-8 Intelligence (multi-trait analysis); CESC cis rs4803468 0.967 rs4605279 chr19:41888131 C/G cg09537434 chr19:41945824 ATP5SL -1.02 -17.99 -0.74 7.57e-48 Height; CESC cis rs6714710 0.603 rs13034929 chr2:98402772 G/C cg26665480 chr2:98280029 ACTR1B 0.68 9.4 0.5 2.59e-18 Posterior cortical atrophy and Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04710198 chr22:47189600 TBC1D22A 0.48 6.29 0.36 1.3e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03828693 chr10:63661686 ARID5B -0.56 -6.68 -0.38 1.4e-10 Gut microbiome composition (summer); CESC cis rs933688 1.000 rs2367353 chr5:90686568 G/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 12.54 0.61 1.26e-28 Smoking behavior; CESC cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg12923728 chr3:195709715 SDHAP1 -0.62 -8.58 -0.47 8.17e-16 Pancreatic cancer; CESC cis rs7223966 1.000 rs7214312 chr17:61870863 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.74 0.38 9.84e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg25811766 chr13:21894605 NA 0.79 11.75 0.59 6.03e-26 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2952156 0.920 rs2517955 chr17:37843681 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.18 -0.3 4.35e-7 Asthma; CESC cis rs62481355 1.000 rs55791028 chr7:127204881 T/C cg25922125 chr7:127225783 GCC1 -0.42 -5.6 -0.33 5.42e-8 Type 2 diabetes; CESC cis rs4722166 0.598 rs7804146 chr7:22800929 C/G cg05472934 chr7:22766657 IL6 0.41 5.5 0.32 8.86e-8 Lung cancer; CESC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg09699651 chr6:150184138 LRP11 0.39 5.03 0.3 9.15e-7 Lung cancer; CESC cis rs6502050 0.723 rs8077209 chr17:80163221 A/G cg23985595 chr17:80112537 CCDC57 -0.4 -6.21 -0.36 1.99e-9 Life satisfaction; CESC cis rs8105265 1 rs8105265 chr19:2920705 A/G cg10661629 chr19:2900748 ZNF57 0.65 5.43 0.32 1.28e-7 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs11048434 0.736 rs11048345 chr12:9123056 T/G cg23795048 chr12:9217529 LOC144571 0.33 5.03 0.3 9.05e-7 Sjögren's syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01997089 chr14:105881679 NA -0.55 -6.42 -0.37 6.1e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13537471 chr19:41351924 CYP2A6 -0.51 -6.88 -0.39 4.33e-11 Gut microbiome composition (summer); CESC cis rs2000999 0.514 rs36061252 chr16:72217613 T/G cg04254540 chr16:71951199 KIAA0174 -0.68 -5.87 -0.34 1.31e-8 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg18404041 chr3:52824283 ITIH1 -0.47 -7.77 -0.43 1.69e-13 Bipolar disorder; CESC cis rs7894051 0.717 rs4838741 chr10:135206873 C/T cg05676341 chr10:135206831 MTG1 0.65 5.69 0.33 3.38e-8 Lifespan; CESC cis rs4654899 0.865 rs6685831 chr1:21507888 G/A cg05370193 chr1:21551575 ECE1 0.46 7.08 0.4 1.28e-11 Superior frontal gyrus grey matter volume; CESC cis rs1152591 0.792 rs1152595 chr14:64674981 T/C cg21174375 chr14:64681225 SYNE2 0.57 7.49 0.42 1.03e-12 Atrial fibrillation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26707263 chr2:241526101 CAPN10 0.66 7.2 0.4 6.25e-12 Gut microbiome composition (summer); CESC cis rs2549003 0.966 rs10072571 chr5:131816711 A/C cg00255919 chr5:131827918 IRF1 0.51 8.59 0.47 7.76e-16 Asthma (sex interaction); CESC cis rs6088580 0.634 rs6059890 chr20:33101653 G/C cg08999081 chr20:33150536 PIGU 0.66 11.5 0.58 4.1e-25 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.88 13.16 0.63 9.11e-31 Prudent dietary pattern; CESC cis rs67478160 0.643 rs11160762 chr14:104255083 A/G cg01849466 chr14:104193079 ZFYVE21 0.51 7.17 0.4 7.31e-12 Schizophrenia; CESC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs2797160 0.874 rs58305111 chr6:126008386 G/T cg05901451 chr6:126070800 HEY2 0.45 6.6 0.38 2.17e-10 Endometrial cancer; CESC cis rs1395 0.677 rs113353646 chr2:27492674 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 5.51 0.32 8.7e-8 Blood metabolite levels; CESC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg10691866 chr7:65817282 TPST1 0.33 5.21 0.3 3.74e-7 Aortic root size; CESC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.71 -8.18 -0.45 1.18e-14 Alzheimer's disease; CESC cis rs9291683 0.632 rs11734375 chr4:10046298 A/G cg02734326 chr4:10020555 SLC2A9 0.47 6.6 0.38 2.23e-10 Bone mineral density; CESC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.58 0.37 2.48e-10 Prudent dietary pattern; CESC cis rs7927771 0.839 rs7124681 chr11:47529947 C/A cg05585544 chr11:47624801 NA -0.41 -6.45 -0.37 5.28e-10 Subjective well-being; CESC cis rs9325144 0.560 rs1843910 chr12:38677408 T/C cg13010199 chr12:38710504 ALG10B -0.45 -6.15 -0.35 2.8e-9 Morning vs. evening chronotype; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg00408597 chr11:9685941 SWAP70 0.45 6.1 0.35 3.74e-9 Bronchopulmonary dysplasia; CESC cis rs72781680 0.898 rs72788214 chr2:24087621 A/C cg08917208 chr2:24149416 ATAD2B 0.91 8.38 0.46 3.17e-15 Lymphocyte counts; CESC cis rs9916302 0.821 rs412430 chr17:37737094 C/G cg00129232 chr17:37814104 STARD3 -0.61 -7.92 -0.44 6.38e-14 Glomerular filtration rate (creatinine); CESC cis rs12048904 0.619 rs10875347 chr1:101333737 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.84 11.21 0.57 3.95e-24 Multiple sclerosis; CESC cis rs28493229 0.522 rs17713068 chr19:41270055 A/C cg21869046 chr19:41225005 ITPKC 0.52 6.84 0.39 5.53e-11 Kawasaki disease; CESC cis rs3820068 0.705 rs4646096 chr1:15820758 A/G cg17385448 chr1:15911702 AGMAT 0.39 6.18 0.35 2.44e-9 Systolic blood pressure; CESC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg24531977 chr5:56204891 C5orf35 -0.44 -5.51 -0.32 8.33e-8 Coronary artery disease; CESC cis rs1153858 1.000 rs7164602 chr15:45671325 A/G cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC cis rs7267979 1.000 rs6050555 chr20:25328543 A/G cg08601574 chr20:25228251 PYGB -0.36 -5.12 -0.3 6e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs6582630 0.638 rs1829584 chr12:38526299 G/T cg26384229 chr12:38710491 ALG10B -0.47 -6.35 -0.36 9.33e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs367943 0.688 rs10063452 chr5:112734165 C/T cg12552261 chr5:112820674 MCC 0.4 5.29 0.31 2.57e-7 Type 2 diabetes; CESC trans rs7726839 0.561 rs72703050 chr5:582917 A/C cg25482853 chr8:67687455 SGK3 0.87 9.18 0.49 1.31e-17 Obesity-related traits; CESC cis rs1707322 1.000 rs785493 chr1:46584859 A/G cg05343316 chr1:45956843 TESK2 -0.47 -5.52 -0.32 7.97e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3105593 1.000 rs8036588 chr15:50956834 C/G cg08437265 chr15:50716283 USP8 0.45 5.9 0.34 1.09e-8 QT interval; CESC cis rs2295499 0.673 rs12506536 chr4:2712403 T/C cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.24 -0.31 3.34e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.64 0.33 4.33e-8 Bipolar disorder; CESC cis rs12477438 0.520 rs13010904 chr2:99754289 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.92 0.7 1.72e-40 Chronic sinus infection; CESC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.5 -0.37 3.97e-10 Parkinson's disease; CESC cis rs2836633 0.929 rs62217518 chr21:40033189 T/G cg05519781 chr21:40033154 ERG 0.79 13.49 0.64 6.12e-32 Coronary artery disease; CESC cis rs2249625 0.874 rs2463727 chr6:72894609 C/T cg18830697 chr6:72922368 RIMS1 -0.37 -5.31 -0.31 2.35e-7 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs4481887 0.927 rs28524655 chr1:248474331 C/T cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC cis rs17376456 0.935 rs13156002 chr5:93508931 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.04 0.3 8.6e-7 Diabetic retinopathy; CESC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg09913183 chr17:42254507 C17orf65;ASB16 0.68 9.05 0.49 3.11e-17 Total body bone mineral density; CESC cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg09796270 chr17:17721594 SREBF1 -0.47 -6.15 -0.35 2.86e-9 Body mass index; CESC cis rs12618769 0.597 rs3769734 chr2:99096149 A/T cg10123293 chr2:99228465 UNC50 0.39 5.14 0.3 5.22e-7 Bipolar disorder; CESC cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.63 7.67 0.43 3.32e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs1499614 1.000 rs1267817 chr7:66110040 G/T cg13147721 chr7:65941812 NA -0.91 -8.45 -0.46 1.99e-15 Gout; CESC cis rs4588572 0.643 rs7716529 chr5:77738637 A/T cg11547950 chr5:77652471 NA -0.44 -5.47 -0.32 1.03e-7 Triglycerides; CESC cis rs7208859 0.673 rs216424 chr17:28943064 T/G cg13385521 chr17:29058706 SUZ12P 0.65 5.57 0.32 6.13e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7772486 0.764 rs2247211 chr6:146216379 G/A cg23711669 chr6:146136114 FBXO30 0.82 11.64 0.58 1.47e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg04511125 chr2:88470314 THNSL2 -0.47 -6.75 -0.38 9.08e-11 Response to metformin (IC50); CESC cis rs7208859 0.673 rs73263785 chr17:29214808 C/T cg19761014 chr17:28927070 LRRC37B2 0.73 5.79 0.34 1.95e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg17372223 chr3:52568218 NT5DC2 0.4 5.59 0.32 5.68e-8 Bipolar disorder; CESC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Depression; CESC cis rs9325144 0.600 rs10785615 chr12:38733627 G/C cg26384229 chr12:38710491 ALG10B 0.55 7.81 0.43 1.32e-13 Morning vs. evening chronotype; CESC cis rs2439831 0.867 rs496584 chr15:43831923 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.73 8.8 0.48 1.84e-16 Lung cancer in ever smokers; CESC cis rs2228479 0.867 rs35542367 chr16:89965825 G/C cg00800038 chr16:89945340 TCF25 -0.85 -7.67 -0.43 3.2e-13 Skin colour saturation; CESC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.24 0.41 4.92e-12 Tonsillectomy; CESC cis rs644799 0.710 rs11021309 chr11:95501898 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.79 0.59 4.45e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs67311347 1.000 rs7628247 chr3:40512682 G/T cg09455208 chr3:40491958 NA -0.49 -8.32 -0.46 4.59e-15 Renal cell carcinoma; CESC cis rs4566357 0.615 rs6436644 chr2:227914275 T/A cg05526886 chr2:227700861 RHBDD1 -0.46 -6.15 -0.35 2.88e-9 Coronary artery disease; CESC cis rs78456975 0.527 rs11901028 chr2:1557972 A/G cg12573674 chr2:1569213 NA -0.45 -5.31 -0.31 2.38e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9513593 1.000 rs7325957 chr13:99965155 C/T cg21788972 chr13:99853209 UBAC2 -0.61 -7.25 -0.41 4.52e-12 Psoriasis; CESC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg04944784 chr2:26401820 FAM59B -0.87 -10.27 -0.53 4.6e-21 Gut microbiome composition (summer); CESC cis rs1580019 0.587 rs6968990 chr7:32552159 C/T cg07520158 chr7:32535189 LSM5;AVL9 -0.54 -6.69 -0.38 1.3e-10 Cognitive ability; CESC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg23161317 chr6:28129485 ZNF389 0.5 6.22 0.36 1.89e-9 Depression; CESC cis rs7267979 0.966 rs910996 chr20:25264196 A/G cg08601574 chr20:25228251 PYGB 0.4 5.76 0.33 2.32e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs72829446 0.530 rs4796422 chr17:7380004 T/C cg02795151 chr17:7402630 POLR2A 0.57 6.07 0.35 4.53e-9 Androgen levels; CESC cis rs9811920 0.609 rs6809988 chr3:99656615 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.59 -7.31 -0.41 3.2e-12 Axial length; CESC cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg09165964 chr15:75287851 SCAMP5 -0.77 -9.53 -0.51 1.07e-18 Blood trace element (Zn levels); CESC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg18240062 chr17:79603768 NPLOC4 0.72 10.27 0.53 4.71e-21 Eye color traits; CESC cis rs9611565 0.559 rs13056262 chr22:42081921 A/G cg03806693 chr22:41940476 POLR3H 1.09 12.68 0.61 4.09e-29 Vitiligo; CESC cis rs698833 0.819 rs698772 chr2:44580634 G/A cg04920474 chr2:44395004 PPM1B 0.36 5.03 0.3 9.04e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg22974920 chr21:40686053 BRWD1 -0.43 -5.22 -0.31 3.61e-7 Cognitive function; CESC cis rs7638909 0.512 rs6793245 chr3:38599037 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.4 5.16 0.3 4.85e-7 Electrocardiographic conduction measures; CESC cis rs4423214 0.592 rs11233933 chr11:71210070 C/T cg05163923 chr11:71159392 DHCR7 -0.55 -5.66 -0.33 3.91e-8 Vitamin D levels; CESC cis rs7116495 0.609 rs10501408 chr11:71680590 C/T cg10381502 chr11:71823885 C11orf51 -1.13 -6.48 -0.37 4.49e-10 Severe influenza A (H1N1) infection; CESC cis rs1707322 1.000 rs785480 chr1:46492164 C/G cg06784218 chr1:46089804 CCDC17 0.35 5.96 0.34 8.03e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg23803603 chr1:2058230 PRKCZ -0.35 -6.15 -0.35 2.77e-9 Height; CESC cis rs60154123 0.505 rs2206043 chr1:210042983 G/A cg22029157 chr1:209979665 IRF6 0.7 7.59 0.42 5.54e-13 Coronary artery disease; CESC cis rs1799949 0.965 rs7223952 chr17:41194885 T/C cg23758822 chr17:41437982 NA 0.97 15.7 0.69 1.06e-39 Menopause (age at onset); CESC cis rs7615952 0.736 rs13063122 chr3:125643860 G/A cg05084668 chr3:125655381 ALG1L -0.5 -5.94 -0.34 8.89e-9 Blood pressure (smoking interaction); CESC cis rs2404602 0.532 rs744336 chr15:76674624 T/C cg00316803 chr15:76480434 C15orf27 -0.36 -5.45 -0.32 1.14e-7 Blood metabolite levels; CESC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg11764359 chr7:65958608 NA 0.97 15.14 0.68 1.02e-37 Aortic root size; CESC cis rs6088580 0.634 rs6087577 chr20:32955423 C/T cg24642439 chr20:33292090 TP53INP2 0.49 6.39 0.37 7.54e-10 Glomerular filtration rate (creatinine); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg16418258 chr15:42840397 LRRC57;HAUS2 -0.45 -6.03 -0.35 5.61e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg17971929 chr21:40555470 PSMG1 -0.64 -8.44 -0.46 2.03e-15 Menarche (age at onset); CESC cis rs6088590 0.687 rs8115656 chr20:33282780 G/C cg24642439 chr20:33292090 TP53INP2 0.69 9.2 0.49 1.09e-17 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13848568 chr1:45965625 CCDC163P;MMACHC 0.58 6.27 0.36 1.46e-9 Gut microbiome composition (summer); CESC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg18876405 chr7:65276391 NA 0.45 6.09 0.35 3.92e-9 Aortic root size; CESC cis rs3749237 0.595 rs7637999 chr3:49535115 C/T cg06212747 chr3:49208901 KLHDC8B 0.49 6.55 0.37 3.02e-10 Resting heart rate; CESC cis rs3105593 0.933 rs3098202 chr15:50838236 C/G cg08437265 chr15:50716283 USP8 0.42 5.43 0.32 1.3e-7 QT interval; CESC trans rs61931739 0.534 rs11052986 chr12:34052578 T/C cg26384229 chr12:38710491 ALG10B 0.51 6.94 0.39 2.97e-11 Morning vs. evening chronotype; CESC cis rs55728055 0.661 rs62237791 chr22:31973124 A/G cg01338084 chr22:32026380 PISD 1.26 8.55 0.47 9.7e-16 Age-related hearing impairment; CESC cis rs6691722 0.503 rs3765427 chr1:24705567 G/A cg02336364 chr1:24764700 NIPAL3 0.34 6.84 0.39 5.52e-11 Response to interferon beta in multiple sclerosis; CESC cis rs244293 0.931 rs244354 chr17:53194142 C/T cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.05 -0.3 8.18e-7 Menarche (age at onset); CESC cis rs7267979 1.000 rs1046073 chr20:25281333 G/A cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs752092 0.802 rs2412005 chr15:101767591 T/A cg19997662 chr15:101784653 CHSY1 -0.42 -5.83 -0.34 1.57e-8 Corneal structure; CESC cis rs1816752 0.905 rs3818938 chr13:25029083 C/T cg02811702 chr13:24901961 NA 0.35 5.11 0.3 6.04e-7 Obesity-related traits; CESC cis rs10870270 1.000 rs6560694 chr10:133773448 G/A cg08754478 chr10:133766260 PPP2R2D -0.59 -7.57 -0.42 6.29e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.23 0.53 6.6e-21 Prudent dietary pattern; CESC cis rs116095464 0.558 rs9688136 chr5:229348 T/C cg20965017 chr5:231967 SDHA -0.45 -5.08 -0.3 7.29e-7 Breast cancer; CESC trans rs208520 0.690 rs207091 chr6:66799847 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.82 -0.62 1.32e-29 Exhaled nitric oxide output; CESC cis rs34779708 0.897 rs7900480 chr10:35338699 A/G cg03585969 chr10:35415529 CREM -0.71 -8.88 -0.48 1.04e-16 Inflammatory bowel disease;Crohn's disease; CESC cis rs909002 0.962 rs7537646 chr1:32135495 G/A cg13919466 chr1:32135498 COL16A1 -0.55 -10.24 -0.53 5.92e-21 Intelligence (multi-trait analysis); CESC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg04414720 chr1:150670196 GOLPH3L 0.58 7.56 0.42 6.44e-13 Melanoma; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg13089318 chr1:80961776 NA -0.44 -6.04 -0.35 5.06e-9 Breast cancer;Type 2 diabetes; CESC trans rs2727020 0.573 rs7925419 chr11:49231859 C/T cg15704280 chr7:45808275 SEPT13 -0.68 -9.01 -0.48 4.1e-17 Coronary artery disease; CESC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg14829155 chr15:31115871 NA 0.77 10.69 0.55 2e-22 Huntington's disease progression; CESC cis rs1559088 0.576 rs11084707 chr19:33612873 C/T cg27124370 chr19:33622961 WDR88 0.52 7.42 0.41 1.64e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs7833986 0.534 rs72653924 chr8:56906088 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.09 0.4 1.2e-11 Height; CESC cis rs3768617 0.510 rs10752903 chr1:183100863 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs9611565 0.649 rs139559 chr22:42191636 A/G cg03806693 chr22:41940476 POLR3H -0.78 -9.42 -0.5 2.28e-18 Vitiligo; CESC trans rs3942852 0.806 rs10769317 chr11:48150712 T/C cg15704280 chr7:45808275 SEPT13 -0.64 -7.37 -0.41 2.13e-12 Acute lymphoblastic leukemia (childhood); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07105891 chr1:21031312 KIF17 -0.57 -6.49 -0.37 4.19e-10 Gut microbiome composition (summer); CESC cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg22823121 chr1:150693482 HORMAD1 -0.41 -6.09 -0.35 3.95e-9 Tonsillectomy; CESC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg27165867 chr14:105738592 BRF1 -0.54 -5.82 -0.34 1.72e-8 Mean platelet volume;Platelet distribution width; CESC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg02038168 chr22:39784481 NA -0.56 -7.63 -0.42 4.28e-13 Intelligence (multi-trait analysis); CESC cis rs5750830 0.594 rs9611165 chr22:39775250 A/G cg02038168 chr22:39784481 NA -0.56 -7.35 -0.41 2.5e-12 Intelligence (multi-trait analysis); CESC cis rs6912958 0.535 rs1753153 chr6:88032834 T/G cg08069147 chr6:88032118 GJB7;C6orf162 0.81 12.34 0.6 6.17e-28 Monocyte percentage of white cells; CESC cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.52 8.43 0.46 2.3e-15 Hemoglobin concentration; CESC cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg16489826 chr6:160211363 TCP1;MRPL18 -0.72 -8.98 -0.48 5.29e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs7845219 0.544 rs34208552 chr8:95908067 C/G cg13393036 chr8:95962371 TP53INP1 -0.44 -8.2 -0.45 1.07e-14 Type 2 diabetes; CESC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg18876405 chr7:65276391 NA -0.55 -6.01 -0.35 6.19e-9 Aortic root size; CESC cis rs881375 0.678 rs7037195 chr9:123684000 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.57 0.32 6.13e-8 Rheumatoid arthritis; CESC cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg09367891 chr1:107599246 PRMT6 -0.72 -8.63 -0.47 5.8e-16 Facial morphology (factor 21, depth of nasal alae); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10225325 chr1:167683897 NA 0.59 6.72 0.38 1.09e-10 Gut microbiome composition (summer); CESC trans rs801193 1.000 rs2707845 chr7:66198798 C/T cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC cis rs12618769 0.652 rs72823794 chr2:99216593 T/A cg10123293 chr2:99228465 UNC50 0.4 5.19 0.3 4.2e-7 Bipolar disorder; CESC cis rs6662572 0.703 rs72690847 chr1:46256929 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.06 0.3 7.99e-7 Blood protein levels; CESC cis rs7267979 0.966 rs2424714 chr20:25418681 T/G cg08601574 chr20:25228251 PYGB 0.38 5.64 0.33 4.4e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9948 0.655 rs62156210 chr2:97393736 A/T cg01990225 chr2:97406019 LMAN2L -1.02 -7.77 -0.43 1.76e-13 Erectile dysfunction and prostate cancer treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08391942 chr5:1386647 NA 0.56 6.11 0.35 3.47e-9 Gut microbiome composition (summer); CESC cis rs4604732 0.631 rs11490198 chr1:247625703 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2228479 0.702 rs62053701 chr16:89860584 G/A cg00800038 chr16:89945340 TCF25 -0.9 -7.49 -0.42 1.01e-12 Skin colour saturation; CESC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.4 0.57 9.22e-25 Alzheimer's disease; CESC cis rs12900413 0.603 rs12905689 chr15:90301343 G/A cg24249390 chr15:90295951 MESP1 -0.38 -5.03 -0.3 9.13e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs1378770 0.508 rs679685 chr7:114364364 A/G cg05338976 chr7:114561850 MDFIC 0.36 5.08 0.3 7.17e-7 Pelvic organ prolapse (moderate/severe); CESC cis rs13294100 0.929 rs8181077 chr9:17580616 A/T cg11213383 chr9:17579734 SH3GL2 -0.39 -5.95 -0.34 8.28e-9 Parkinson's disease; CESC trans rs2235573 0.625 rs139900 chr22:38405417 C/T cg19894588 chr14:64061835 NA 0.52 6.6 0.38 2.17e-10 Glioblastoma;Glioma; CESC cis rs897080 0.515 rs1085444 chr2:44624155 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs4588572 0.644 rs2115435 chr5:77723700 A/C cg11547950 chr5:77652471 NA -0.48 -6.79 -0.38 7.4e-11 Triglycerides; CESC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg10691866 chr7:65817282 TPST1 0.33 5.49 0.32 9.61e-8 Aortic root size; CESC cis rs5769765 0.955 rs4075330 chr22:50303249 G/A cg26441486 chr22:50317300 CRELD2 0.43 5.64 0.33 4.32e-8 Schizophrenia; CESC cis rs7084402 0.967 rs1658485 chr10:60288331 A/G cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs9894429 0.752 rs7502883 chr17:79588557 T/C cg13777783 chr17:79615861 NA -0.33 -5.24 -0.31 3.35e-7 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17059263 chr4:154266522 MND1 -0.56 -6.48 -0.37 4.41e-10 Gut microbiome composition (summer); CESC cis rs4423214 0.592 rs7114252 chr11:71237606 G/A cg05163923 chr11:71159392 DHCR7 -0.54 -5.64 -0.33 4.34e-8 Vitamin D levels; CESC cis rs728616 0.867 rs12412226 chr10:81735288 C/T cg05935833 chr10:81318306 SFTPA2 -0.51 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs5769765 0.908 rs9616216 chr22:50318927 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.62 -6.38 -0.37 7.75e-10 Schizophrenia; CESC cis rs9467711 0.606 rs2073529 chr6:26375159 C/T cg14345882 chr6:26364793 BTN3A2 -0.66 -6.37 -0.36 8.35e-10 Autism spectrum disorder or schizophrenia; CESC cis rs7824557 0.505 rs2736313 chr8:11086942 C/T cg21775007 chr8:11205619 TDH 0.38 5.44 0.32 1.22e-7 Retinal vascular caliber; CESC cis rs11958404 0.932 rs72816547 chr5:157417820 G/T cg05962755 chr5:157440814 NA 0.62 6.47 0.37 4.68e-10 IgG glycosylation; CESC cis rs8067545 0.611 rs77449863 chr17:20191860 C/G cg13482628 chr17:19912719 NA -0.42 -5.61 -0.33 5.2e-8 Schizophrenia; CESC cis rs9430161 0.611 rs34032547 chr1:11034374 C/G cg02454025 chr1:11042201 C1orf127 0.99 16.1 0.7 3.84e-41 Ewing sarcoma; CESC cis rs2249625 0.508 rs60020363 chr6:72844706 C/T cg18830697 chr6:72922368 RIMS1 0.43 6.23 0.36 1.81e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg11644478 chr21:40555479 PSMG1 0.61 8.23 0.45 8.45e-15 Cognitive function; CESC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.56 0.47 9.4e-16 Bipolar disorder; CESC cis rs7917772 0.628 rs4604806 chr10:104373904 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.39 5.41 0.32 1.43e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9596863 1.000 rs1545659 chr13:54433788 G/A ch.13.53330881F chr13:54432880 NA -0.63 -5.37 -0.31 1.74e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs1790761 0.667 rs1254123 chr11:67334812 T/C cg00290607 chr11:67383545 NA 0.39 5.48 0.32 1.01e-7 Mean corpuscular volume; CESC cis rs7917772 0.582 rs10786682 chr10:104318322 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.41 -5.65 -0.33 4.17e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6061231 0.561 rs67072353 chr20:60940702 G/A cg22601191 chr20:60968625 CABLES2 0.49 5.06 0.3 7.81e-7 Colorectal cancer; CESC cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg22875332 chr1:76189707 ACADM 0.59 5.78 0.33 2.09e-8 Blood metabolite levels;Acylcarnitine levels; CESC trans rs61931739 0.500 rs7310237 chr12:34483435 G/A cg26384229 chr12:38710491 ALG10B 0.55 7.58 0.42 5.66e-13 Morning vs. evening chronotype; CESC cis rs2075671 0.903 rs4727459 chr7:100276821 T/C cg16850897 chr7:100343110 ZAN -0.7 -8.88 -0.48 1.04e-16 Other erythrocyte phenotypes; CESC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg27266027 chr21:40555129 PSMG1 0.48 5.72 0.33 2.87e-8 Cognitive function; CESC cis rs7089973 0.872 rs7918253 chr10:116614501 T/C cg25233709 chr10:116636983 FAM160B1 0.35 5.08 0.3 7.02e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 5.87 0.34 1.32e-8 Colorectal cancer; CESC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg22963979 chr7:1858916 MAD1L1 -0.43 -5.89 -0.34 1.2e-8 Bipolar disorder and schizophrenia; CESC cis rs10129255 0.701 rs2005643 chr14:107132304 C/T cg23076370 chr14:107095027 NA -0.52 -7.23 -0.41 5.23e-12 Kawasaki disease; CESC cis rs1707322 0.752 rs28623463 chr1:46170758 A/C cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9549260 0.755 rs59308928 chr13:41245079 C/T cg21288729 chr13:41239152 FOXO1 0.68 8.49 0.46 1.51e-15 Red blood cell count; CESC cis rs4523957 0.928 rs11872068 chr17:2176528 G/A cg16513277 chr17:2031491 SMG6 -0.56 -7.42 -0.41 1.55e-12 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg10691866 chr7:65817282 TPST1 0.3 5.17 0.3 4.51e-7 Aortic root size; CESC cis rs3126085 0.935 rs6587651 chr1:152193121 G/T cg26876637 chr1:152193138 HRNR 0.48 5.51 0.32 8.31e-8 Atopic dermatitis; CESC cis rs11650494 0.908 rs77488129 chr17:47448970 G/A cg08112188 chr17:47440006 ZNF652 1.28 8.54 0.46 1.1e-15 Prostate cancer; CESC cis rs7599312 0.534 rs7607363 chr2:213402705 A/G cg20637307 chr2:213403960 ERBB4 0.57 8.92 0.48 7.78e-17 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11604216 chr8:124031034 DERL1 0.41 6.01 0.35 5.97e-9 Gut microbiota (bacterial taxa); CESC cis rs367943 0.667 rs13173069 chr5:113011778 T/G cg12552261 chr5:112820674 MCC 0.44 5.3 0.31 2.48e-7 Type 2 diabetes; CESC cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs12971120 0.838 rs2241510 chr18:72180739 G/A cg25817165 chr18:72167213 CNDP2 -0.63 -7.64 -0.42 4.08e-13 Refractive error; CESC cis rs6426558 0.559 rs7549520 chr1:227258858 G/C cg10327440 chr1:227177885 CDC42BPA 0.47 5.75 0.33 2.42e-8 Neutrophil percentage of white cells; CESC cis rs1580019 0.534 rs13237495 chr7:32560687 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.03 18.4 0.75 2.8e-49 Cognitive ability; CESC cis rs763014 0.931 rs7191939 chr16:630089 C/T cg07343612 chr16:622815 PIGQ -0.58 -8.44 -0.46 2.07e-15 Height; CESC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg06634786 chr22:41940651 POLR3H -0.65 -6.85 -0.39 5.03e-11 Vitiligo; CESC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs10924309 0.686 rs4658796 chr1:245854680 A/G cg00036263 chr1:245852353 KIF26B -0.51 -6.44 -0.37 5.51e-10 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs1545257 0.505 rs2584950 chr2:24632762 A/G cg06627628 chr2:24431161 ITSN2 -0.48 -5.82 -0.34 1.74e-8 Sjögren's syndrome; CESC cis rs1005277 0.540 rs7903942 chr10:37929276 C/T cg25517755 chr10:38738941 LOC399744 0.41 5.38 0.31 1.64e-7 Extrinsic epigenetic age acceleration; CESC cis rs1670533 1.000 rs2290408 chr4:1067267 A/C cg27284194 chr4:1044797 NA -0.47 -6.11 -0.35 3.61e-9 Recombination rate (females); CESC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg14393609 chr7:65229607 NA -0.46 -6.16 -0.35 2.65e-9 Aortic root size; CESC cis rs3820928 0.933 rs1429267 chr2:227767593 G/C cg11843606 chr2:227700838 RHBDD1 -0.43 -5.71 -0.33 3.04e-8 Pulmonary function; CESC cis rs10088262 0.591 rs13270541 chr8:124794849 G/A cg15047889 chr8:124780837 FAM91A1 -0.52 -6.58 -0.37 2.57e-10 Pancreatic cancer; CESC cis rs897984 0.609 rs17839567 chr16:31057945 A/G cg02466173 chr16:30829666 NA -0.39 -6.77 -0.38 8.4e-11 Dementia with Lewy bodies; CESC cis rs9549367 0.789 rs2287253 chr13:113891075 G/A cg00898013 chr13:113819073 PROZ 0.48 6.75 0.38 9.17e-11 Platelet distribution width; CESC cis rs965469 0.603 rs6115892 chr20:3411569 C/T cg25506879 chr20:3388711 C20orf194 -0.46 -5.58 -0.32 6.07e-8 IFN-related cytopenia; CESC cis rs10504229 0.813 rs6999878 chr8:58197243 C/G cg22535103 chr8:58192502 C8orf71 -0.75 -8.89 -0.48 9.68e-17 Developmental language disorder (linguistic errors); CESC cis rs2777491 1.000 rs316613 chr15:41747598 G/A cg18705301 chr15:41695430 NDUFAF1 -0.64 -9.84 -0.52 1.16e-19 Ulcerative colitis; CESC trans rs35110281 0.563 rs162371 chr21:44931489 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 6.62 0.38 1.94e-10 Mean corpuscular volume; CESC trans rs7937682 0.889 rs559482 chr11:111497902 G/A cg18187862 chr3:45730750 SACM1L 0.52 6.57 0.37 2.6e-10 Primary sclerosing cholangitis; CESC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg25204440 chr1:209979598 IRF6 0.6 7.66 0.43 3.51e-13 Cleft lip with or without cleft palate; CESC cis rs818427 0.593 rs419155 chr5:112210415 A/T cg07820702 chr5:112228657 REEP5 -0.4 -5.34 -0.31 2.02e-7 Total body bone mineral density; CESC cis rs4808199 1.000 rs60003758 chr19:19557353 A/G cg03709012 chr19:19516395 GATAD2A 1.14 13.23 0.63 4.9e-31 Nonalcoholic fatty liver disease; CESC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg14262678 chr6:151773367 RMND1;C6orf211 0.66 9.32 0.5 4.58e-18 Menarche (age at onset); CESC cis rs28386778 0.700 rs12449555 chr17:62003982 T/A cg11494091 chr17:61959527 GH2 -0.81 -14.38 -0.66 4.62e-35 Prudent dietary pattern; CESC cis rs2295359 0.892 rs10789224 chr1:67605134 C/T cg03340356 chr1:67600835 NA -0.31 -5.21 -0.3 3.86e-7 Psoriasis; CESC cis rs1904096 0.506 rs4558832 chr4:95148042 G/A cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 Type 2 diabetes; CESC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg25036284 chr2:26402008 FAM59B 0.86 9.41 0.5 2.53e-18 Gut microbiome composition (summer); CESC trans rs1814175 0.546 rs1614397 chr11:49913384 G/C cg15704280 chr7:45808275 SEPT13 -1.03 -20.27 -0.78 8.31e-56 Height; CESC cis rs992157 0.560 rs7578940 chr2:219083318 G/T cg20019365 chr2:219134978 PNKD;AAMP -0.58 -7.54 -0.42 7.32e-13 Colorectal cancer; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg08283932 chr20:43280707 ADA -0.49 -6.54 -0.37 3.13e-10 Thyroid stimulating hormone; CESC cis rs889398 0.835 rs62050037 chr16:69784670 T/C cg09409435 chr16:70099608 PDXDC2 -0.41 -5.06 -0.3 7.72e-7 Body mass index; CESC trans rs2727020 0.658 rs10839269 chr11:49385596 A/G cg15704280 chr7:45808275 SEPT13 -0.91 -15.87 -0.7 2.58e-40 Coronary artery disease; CESC cis rs2228479 0.541 rs12918575 chr16:89811151 A/G cg14709524 chr16:89940631 TCF25 0.63 5.69 0.33 3.43e-8 Skin colour saturation; CESC cis rs6493487 0.512 rs28366661 chr15:51258315 A/G cg02338191 chr15:51200825 AP4E1 0.6 5.6 0.33 5.43e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs965469 0.779 rs6051785 chr20:3339199 C/T cg17110299 chr20:3385021 C20orf194 0.4 5.26 0.31 3.02e-7 IFN-related cytopenia; CESC cis rs17764205 0.929 rs57643778 chr19:3257020 C/T cg04171554 chr19:2761892 SGTA -0.54 -5.06 -0.3 7.98e-7 Bipolar disorder and schizophrenia; CESC cis rs7264396 0.690 rs2425180 chr20:34447160 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -11.57 -0.58 2.56e-25 Total cholesterol levels; CESC cis rs2370759 1.000 rs2225152 chr10:32574759 T/C cg18270830 chr10:32634957 EPC1 0.73 7.28 0.41 3.73e-12 Sexual dysfunction (female); CESC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.31 0.31 2.32e-7 Bipolar disorder; CESC cis rs3796352 0.764 rs11714902 chr3:53101544 G/C cg12962167 chr3:53033115 SFMBT1 0.72 6.37 0.36 8.3e-10 Immune reponse to smallpox (secreted IL-2); CESC cis rs116095464 0.558 rs6555056 chr5:226222 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.58 0.32 5.88e-8 Breast cancer; CESC cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg02935154 chr7:12443704 VWDE -0.53 -6.68 -0.38 1.38e-10 Coronary artery disease; CESC cis rs7202877 0.656 rs9923834 chr16:75507253 T/A cg03315344 chr16:75512273 CHST6 0.53 5.26 0.31 3.03e-7 Type 2 diabetes;Type 1 diabetes; CESC cis rs78707713 0.560 rs55668536 chr10:71242655 A/G cg12610070 chr10:71211762 TSPAN15 -0.33 -7.01 -0.4 1.99e-11 Venous thromboembolism; CESC cis rs7824557 0.778 rs3808502 chr8:11179458 G/T cg21775007 chr8:11205619 TDH 0.48 6.94 0.39 3.05e-11 Retinal vascular caliber; CESC cis rs11048434 0.612 rs7299653 chr12:9058993 A/T cg23795048 chr12:9217529 LOC144571 0.32 5.03 0.3 9.05e-7 Sjögren's syndrome; CESC cis rs6866344 0.697 rs58549512 chr5:178133204 C/T cg10224037 chr5:178157518 ZNF354A 0.66 7.23 0.41 5.03e-12 Neutrophil percentage of white cells; CESC cis rs72781680 0.716 rs72788284 chr2:24097539 A/G cg08917208 chr2:24149416 ATAD2B 0.58 5.81 0.34 1.82e-8 Lymphocyte counts; CESC cis rs10870270 1.000 rs10870271 chr10:133754807 A/G cg08754478 chr10:133766260 PPP2R2D 0.63 8.23 0.45 8.79e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11815682 chr21:44486381 CBS -0.59 -6.3 -0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs668210 0.947 rs559161 chr11:65761637 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.47 5.17 0.3 4.62e-7 Cerebrospinal fluid biomarker levels; CESC cis rs137603 0.644 rs137635 chr22:39720656 G/C cg01093212 chr22:39715156 SNORD43;RPL3 -0.43 -5.6 -0.33 5.33e-8 Primary biliary cholangitis; CESC cis rs763121 0.853 rs4821810 chr22:39072098 C/G cg06022373 chr22:39101656 GTPBP1 0.94 18.23 0.75 1.15e-48 Menopause (age at onset); CESC cis rs7520050 0.966 rs6429582 chr1:46321843 C/T cg03146154 chr1:46216737 IPP 0.48 6.23 0.36 1.82e-9 Red blood cell count;Reticulocyte count; CESC cis rs4660306 0.961 rs1337902 chr1:45952066 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.76 -0.43 1.85e-13 Homocysteine levels; CESC cis rs4535700 0.501 rs57251705 chr7:55981083 A/G cg09872392 chr7:56161020 PHKG1 0.41 5.81 0.34 1.8e-8 Macular telangiectasia type 2; CESC cis rs8180040 0.654 rs13078131 chr3:47204939 G/T cg27129171 chr3:47204927 SETD2 0.72 11.24 0.57 3.23e-24 Colorectal cancer; CESC cis rs870825 0.520 rs10022842 chr4:185649459 A/G cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs9354308 0.899 rs2802058 chr6:66550787 T/G cg07460842 chr6:66804631 NA 0.6 6.77 0.38 8.12e-11 Metabolite levels; CESC cis rs4930561 0.739 rs10896303 chr11:67974292 C/A cg16338278 chr11:67432957 ALDH3B2 0.43 5.3 0.31 2.43e-7 Breast cancer in childhood cancer survivors;IgG glycosylation; CESC cis rs45535039 1.000 rs7113047 chr11:119108112 A/G cg16724696 chr11:118992527 HINFP 0.42 5.42 0.32 1.33e-7 Plateletcrit; CESC cis rs7949030 0.596 rs11231138 chr11:62316195 C/G cg11742103 chr11:62369870 EML3;MTA2 0.63 9.34 0.5 4.06e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs12136530 0.594 rs4912082 chr1:19716796 T/C cg01832549 chr1:19774989 CAPZB -0.4 -5.63 -0.33 4.51e-8 Lead levels in blood; CESC cis rs921968 0.565 rs7605055 chr2:219627050 G/C cg02176678 chr2:219576539 TTLL4 -0.44 -7.73 -0.43 2.21e-13 Mean corpuscular hemoglobin concentration; CESC cis rs7666738 0.519 rs28539191 chr4:98821552 C/T cg17366294 chr4:99064904 C4orf37 0.49 5.94 0.34 9.14e-9 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24322668 chr19:3838098 ZFR2 -0.5 -6.32 -0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs4604732 0.588 rs12045675 chr1:247623915 C/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.49 6.07 0.35 4.52e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs73072330 0.643 rs56298666 chr3:47667218 A/G cg04507495 chr3:47563649 NA 1.12 7.57 0.42 6.32e-13 Stem cell growth factor beta levels; CESC cis rs367943 0.712 rs1607159 chr5:112681044 C/A cg12552261 chr5:112820674 MCC 0.4 5.25 0.31 3.09e-7 Type 2 diabetes; CESC cis rs6840360 0.615 rs7669465 chr4:152609289 C/T cg22705602 chr4:152727874 NA -0.36 -5.04 -0.3 8.52e-7 Intelligence (multi-trait analysis); CESC cis rs9486719 0.895 rs11152960 chr6:96900398 A/G cg06623918 chr6:96969491 KIAA0776 -0.81 -8.3 -0.45 5.21e-15 Migraine;Coronary artery disease; CESC trans rs9354352 1.000 rs9354352 chr6:66696272 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 9.93 0.52 5.77e-20 Initial pursuit acceleration in psychotic disorders; CESC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg04414720 chr1:150670196 GOLPH3L 0.63 9.0 0.48 4.53e-17 Tonsillectomy; CESC cis rs9911578 1.000 rs9898916 chr17:57048660 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.08 0.3 7.21e-7 Intelligence (multi-trait analysis); CESC cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg05283184 chr6:79620031 NA -0.43 -6.59 -0.38 2.34e-10 Intelligence (multi-trait analysis); CESC cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg24296786 chr1:45957014 TESK2 0.63 8.45 0.46 1.99e-15 High light scatter reticulocyte count; CESC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg24250549 chr1:154909240 PMVK 0.6 8.12 0.45 1.74e-14 Prostate cancer; CESC trans rs10435719 0.902 rs7459545 chr8:11804389 G/T cg15556689 chr8:8085844 FLJ10661 0.53 6.71 0.38 1.14e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs6430585 0.528 rs309165 chr2:136667301 T/C cg07169764 chr2:136633963 MCM6 1.08 16.51 0.71 1.41e-42 Corneal structure; CESC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg06873352 chr17:61820015 STRADA 0.73 12.89 0.62 7.87e-30 Prudent dietary pattern; CESC cis rs9287719 0.967 rs7566875 chr2:10754792 T/C cg00105475 chr2:10696890 NA 0.38 5.42 0.32 1.34e-7 Prostate cancer; CESC cis rs5769707 0.967 rs4524218 chr22:50018639 G/A cg05373962 chr22:49881684 NA -0.38 -6.73 -0.38 1.04e-10 Monocyte count;Monocyte percentage of white cells; CESC cis rs9611565 0.545 rs5758432 chr22:42111693 T/C cg17376030 chr22:41985996 PMM1 -0.81 -8.6 -0.47 7.13e-16 Vitiligo; CESC cis rs854765 0.547 rs8075189 chr17:17901946 C/G cg04398451 chr17:18023971 MYO15A -0.69 -10.33 -0.54 3.02e-21 Total body bone mineral density; CESC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg19163074 chr7:65112434 INTS4L2 -0.41 -5.1 -0.3 6.39e-7 Aortic root size; CESC cis rs67311347 0.955 rs4974068 chr3:40376929 T/C cg09455208 chr3:40491958 NA 0.52 9.12 0.49 1.91e-17 Renal cell carcinoma; CESC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg00074818 chr8:8560427 CLDN23 0.36 5.41 0.32 1.42e-7 Obesity-related traits; CESC trans rs2207136 0.868 rs2207138 chr6:50841355 G/A cg06522515 chr3:184090630 THPO -0.35 -6.18 -0.35 2.43e-9 Myopia; CESC cis rs7264396 0.790 rs2425096 chr20:34308588 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.62 7.38 0.41 2.01e-12 Total cholesterol levels; CESC cis rs1568889 0.938 rs1464898 chr11:28034748 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.02 0.56 1.73e-23 Bipolar disorder; CESC cis rs367943 0.871 rs348940 chr5:112824530 C/A cg12552261 chr5:112820674 MCC -0.59 -7.57 -0.42 6.04e-13 Type 2 diabetes; CESC cis rs3857536 0.776 rs2040593 chr6:66944076 G/A cg07460842 chr6:66804631 NA -0.41 -5.22 -0.31 3.67e-7 Blood trace element (Cu levels); CESC cis rs9640161 0.789 rs66688634 chr7:150053806 G/A cg10018233 chr7:150070692 REPIN1 0.41 5.88 0.34 1.24e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs4304924 0.500 rs12585725 chr13:79220899 C/A cg07926092 chr13:79233506 RNF219 0.61 6.68 0.38 1.43e-10 Large artery stroke; CESC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg09323728 chr8:95962352 TP53INP1 -0.4 -8.68 -0.47 4.05e-16 Type 2 diabetes; CESC cis rs8114671 0.562 rs2424999 chr20:33386430 G/A cg07148914 chr20:33460835 GGT7 0.47 5.9 0.34 1.12e-8 Height; CESC cis rs1707322 0.681 rs12048866 chr1:46117492 T/G cg03146154 chr1:46216737 IPP 0.82 11.51 0.58 3.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.44 -5.04 -0.3 8.66e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07936931 chr19:21933455 LOC641367;ZNF100 -0.55 -6.08 -0.35 4.09e-9 Gut microbiome composition (summer); CESC cis rs6545883 0.965 rs6545872 chr2:61724568 G/A cg15711740 chr2:61764176 XPO1 -0.42 -5.27 -0.31 2.81e-7 Tuberculosis; CESC cis rs2439831 0.867 rs2242068 chr15:43699304 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.8 10.67 0.55 2.47e-22 Lung cancer in ever smokers; CESC cis rs3733585 0.660 rs13122290 chr4:9933832 A/G cg11266682 chr4:10021025 SLC2A9 -0.55 -10.42 -0.54 1.54e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4835473 0.778 rs75562808 chr4:144700218 T/A cg25736465 chr4:144833511 NA -0.33 -5.14 -0.3 5.37e-7 Immature fraction of reticulocytes; CESC cis rs728616 0.614 rs56147535 chr10:82027625 G/T cg05935833 chr10:81318306 SFTPA2 -0.44 -5.72 -0.33 2.9e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9486719 1.000 rs12205728 chr6:96891838 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs4819052 0.851 rs2838867 chr21:46713092 C/T cg11663144 chr21:46675770 NA -0.62 -9.33 -0.5 4.43e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg18555811 chr3:193852889 HES1 0.48 6.82 0.39 6.15e-11 Myopia (pathological); CESC cis rs2880765 0.835 rs7161880 chr15:86018746 C/T cg10818794 chr15:86012489 AKAP13 -0.33 -5.17 -0.3 4.6e-7 Coronary artery disease; CESC cis rs116095464 0.558 rs13357299 chr5:242211 T/C cg10591111 chr5:226296 SDHA -0.51 -6.26 -0.36 1.54e-9 Breast cancer; CESC cis rs6460942 1.000 rs62448563 chr7:12400040 G/A cg20607287 chr7:12443886 VWDE -0.67 -7.72 -0.43 2.43e-13 Coronary artery disease; CESC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg16325326 chr1:53192061 ZYG11B -0.88 -15.06 -0.68 1.8e-37 Monocyte count; CESC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg10150615 chr22:24372951 LOC391322 0.56 7.6 0.42 5.07e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7973683 0.541 rs6488910 chr12:124393697 G/T cg12597309 chr12:124393772 DNAH10 0.25 5.75 0.33 2.39e-8 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC trans rs6951245 0.554 rs4724294 chr7:1139695 G/A cg13565492 chr6:43139072 SRF -0.75 -9.04 -0.49 3.45e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC trans rs853679 0.882 rs9468300 chr6:28126840 C/T cg06606381 chr12:133084897 FBRSL1 -0.67 -6.37 -0.36 8.17e-10 Depression; CESC cis rs9611565 0.649 rs79005 chr22:41835544 G/A cg17376030 chr22:41985996 PMM1 -0.56 -6.22 -0.36 1.92e-9 Vitiligo; CESC cis rs1062746 1.000 rs1062746 chr16:87364650 A/G cg02258303 chr16:87377426 FBXO31 -0.42 -5.33 -0.31 2.15e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CESC cis rs6582630 0.555 rs10785443 chr12:38463792 A/C cg26384229 chr12:38710491 ALG10B 0.66 10.07 0.53 2.14e-20 Drug-induced liver injury (flucloxacillin); CESC cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2404602 0.669 rs12148877 chr15:76919959 T/G cg26408565 chr15:76604113 ETFA -0.39 -5.51 -0.32 8.57e-8 Blood metabolite levels; CESC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg25072359 chr17:41440525 NA 0.5 6.78 0.38 7.72e-11 Menopause (age at onset); CESC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg24829409 chr8:58192753 C8orf71 -0.59 -7.24 -0.41 4.79e-12 Developmental language disorder (linguistic errors); CESC cis rs977987 0.866 rs12932606 chr16:75493944 C/T cg03315344 chr16:75512273 CHST6 0.54 7.77 0.43 1.75e-13 Dupuytren's disease; CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg07167872 chr1:205819463 PM20D1 0.83 14.85 0.67 1.07e-36 Menarche (age at onset); CESC cis rs10088262 0.629 rs9918907 chr8:124816862 A/G cg20713898 chr8:124780851 FAM91A1 -0.66 -8.75 -0.47 2.61e-16 Pancreatic cancer; CESC cis rs11148252 0.574 rs61958118 chr13:53170226 C/T cg00495681 chr13:53174319 NA 0.64 8.91 0.48 8.65e-17 Lewy body disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03760316 chr18:3594197 DLGAP1;FLJ35776 -0.45 -6.35 -0.36 9.27e-10 Gambling; CESC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg23048001 chr7:2026167 MAD1L1 0.44 5.76 0.33 2.33e-8 Schizophrenia; CESC cis rs10751667 0.580 rs11246363 chr11:971667 T/C cg06064525 chr11:970664 AP2A2 -0.45 -8.8 -0.48 1.82e-16 Alzheimer's disease (late onset); CESC cis rs7202877 0.706 rs37605 chr16:75506572 G/C cg04384234 chr16:75411784 CFDP1 0.49 5.9 0.34 1.13e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs2066819 1.000 rs11575234 chr12:56744276 C/G cg26316697 chr12:56727976 PAN2 0.72 6.94 0.39 2.92e-11 Psoriasis vulgaris; CESC cis rs6489785 0.710 rs3213566 chr12:121222578 T/C cg02419362 chr12:121203948 SPPL3 0.36 5.87 0.34 1.27e-8 Longevity;Allergic disease (asthma, hay fever or eczema); CESC cis rs4474465 0.688 rs7940720 chr11:78276674 C/T cg27205649 chr11:78285834 NARS2 0.46 6.21 0.36 2.06e-9 Alzheimer's disease (survival time); CESC cis rs6540556 0.859 rs11119340 chr1:209940560 A/T cg05527609 chr1:210001259 C1orf107 0.73 8.24 0.45 8.03e-15 Red blood cell count; CESC cis rs7582720 1.000 rs114155121 chr2:203718682 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs2243480 0.901 rs12530490 chr7:65691647 G/A cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs892961 1.000 rs2164449 chr17:75401190 G/A cg05865280 chr17:75406074 SEPT9 0.66 13.11 0.63 1.34e-30 Airflow obstruction; CESC cis rs9467711 0.606 rs13203358 chr6:26590578 A/T cg21479132 chr6:26055353 NA 0.64 5.42 0.32 1.31e-7 Autism spectrum disorder or schizophrenia; CESC cis rs35955747 0.869 rs8141987 chr22:31587155 C/G cg25791279 chr22:32026902 PISD -0.41 -5.11 -0.3 6.14e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs8068544 0.818 rs8079958 chr17:40155467 C/T cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -0.94 -8.56 -0.47 9.34e-16 Reticulocyte fraction of red cells;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08830818 chr3:122514143 HSPBAP1;DIRC2 0.52 6.47 0.37 4.82e-10 Gut microbiome composition (summer); CESC cis rs2865126 0.743 rs2865120 chr18:10754921 A/G cg21165219 chr18:10698044 FAM38B -0.5 -5.18 -0.3 4.48e-7 Metabolite levels (5-HIAA/ MHPG Ratio); CESC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg00121533 chr1:75199117 CRYZ;TYW3 0.54 7.24 0.41 4.98e-12 Resistin levels; CESC cis rs36051895 0.589 rs10122037 chr9:5192874 A/G cg02405213 chr9:5042618 JAK2 0.51 6.27 0.36 1.45e-9 Pediatric autoimmune diseases; CESC cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg10596483 chr8:143751796 JRK -0.46 -5.26 -0.31 3.01e-7 Urinary tract infection frequency; CESC cis rs2066819 1.000 rs41363748 chr12:56696056 C/T cg26734620 chr12:56694298 CS -1.06 -6.59 -0.38 2.42e-10 Psoriasis vulgaris; CESC cis rs12368653 1.000 rs12368653 chr12:58133256 A/G cg00677455 chr12:58241039 CTDSP2 0.42 5.54 0.32 7.43e-8 Multiple sclerosis; CESC cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2795502 1.000 rs2795502 chr10:43340662 G/A cg27426351 chr10:43362370 NA -0.48 -6.0 -0.35 6.51e-9 Blood protein levels; CESC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg25072359 chr17:41440525 NA 0.46 6.21 0.36 2.01e-9 Menopause (age at onset); CESC cis rs34375054 0.573 rs12581813 chr12:125656402 A/G cg25124228 chr12:125621409 AACS -0.5 -5.35 -0.31 1.94e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs11608355 0.545 rs11066782 chr12:109910552 C/T cg05360138 chr12:110035743 NA 0.81 8.75 0.47 2.52e-16 Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25198656 chr7:5013641 RNF216L 0.63 7.48 0.42 1.09e-12 Gut microbiome composition (summer); CESC cis rs4423214 1.000 rs11600860 chr11:71164019 T/C cg05163923 chr11:71159392 DHCR7 0.76 10.16 0.53 1.05e-20 Vitamin D levels; CESC cis rs9911578 0.967 rs2567892 chr17:56668929 T/C cg12560992 chr17:57184187 TRIM37 0.93 15.43 0.69 9.21e-39 Intelligence (multi-trait analysis); CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg09177884 chr7:1199841 ZFAND2A -0.64 -8.53 -0.46 1.16e-15 Longevity;Endometriosis; CESC cis rs2204008 0.805 rs11514348 chr12:38243427 T/C cg26384229 chr12:38710491 ALG10B 0.71 10.11 0.53 1.52e-20 Bladder cancer; CESC cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg17366294 chr4:99064904 C4orf37 0.57 7.98 0.44 4.33e-14 Colonoscopy-negative controls vs population controls; CESC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg22433210 chr17:43662623 NA -0.85 -9.75 -0.51 2.16e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.98 9.78 0.52 1.7e-19 Platelet count; CESC cis rs10744422 0.858 rs7980541 chr12:123379477 C/T cg22842854 chr12:123319900 HIP1R -0.64 -5.35 -0.31 1.87e-7 Schizophrenia; CESC cis rs4950322 0.570 rs72692914 chr1:146774637 T/A cg22381352 chr1:146742008 CHD1L -0.47 -5.11 -0.3 6.24e-7 Protein quantitative trait loci; CESC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg27266027 chr21:40555129 PSMG1 -0.4 -5.13 -0.3 5.63e-7 Cognitive function; CESC cis rs7795096 0.743 rs9648730 chr7:151537785 G/A cg17008978 chr7:151542804 PRKAG2 0.39 7.37 0.41 2.15e-12 Bipolar disorder (age of onset and psychotic symptoms); CESC cis rs2191566 1.000 rs2356549 chr19:44511202 A/T cg20607764 chr19:44506953 ZNF230 -0.6 -7.76 -0.43 1.9e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs1008375 1.000 rs10009541 chr4:17682218 C/T cg02297831 chr4:17616191 MED28 -0.48 -5.81 -0.34 1.77e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7209460 0.556 rs2316513 chr17:1988377 A/T cg20777128 chr17:1945076 DPH1;OVCA2 -0.43 -5.06 -0.3 7.83e-7 Coronary artery disease;Total body bone mineral density; CESC cis rs4481887 0.830 rs10888341 chr1:248441995 T/C cg00666640 chr1:248458726 OR2T12 0.39 6.6 0.38 2.23e-10 Common traits (Other); CESC trans rs12599106 0.625 rs12923277 chr16:34896261 G/A cg01516881 chr6:292596 DUSP22 -0.84 -11.22 -0.57 3.59e-24 Menopause (age at onset); CESC trans rs17685 0.753 rs6465000 chr7:75787417 G/A cg19862616 chr7:65841803 NCRNA00174 0.85 12.42 0.61 3.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs965469 0.553 rs6051767 chr20:3324521 C/T cg25506879 chr20:3388711 C20orf194 -0.44 -5.25 -0.31 3.08e-7 IFN-related cytopenia; CESC cis rs1348850 0.526 rs2218575 chr2:178368997 C/A cg23306229 chr2:178417860 TTC30B 0.8 7.39 0.41 1.96e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6088580 0.634 rs6059850 chr20:33044784 C/G cg08999081 chr20:33150536 PIGU 0.67 12.04 0.59 6.52e-27 Glomerular filtration rate (creatinine); CESC cis rs4664304 0.772 rs12692572 chr2:160743793 G/A cg03641300 chr2:160917029 PLA2R1 0.42 5.99 0.35 6.71e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs1790761 0.505 rs7941648 chr11:67347595 C/T cg14500267 chr11:67383377 NA -0.31 -5.12 -0.3 5.81e-7 Mean corpuscular volume; CESC cis rs8141529 0.732 rs5762788 chr22:29174770 G/T cg15103426 chr22:29168792 CCDC117 0.73 10.22 0.53 7.13e-21 Lymphocyte counts; CESC cis rs1018836 0.923 rs1476427 chr8:91552791 A/G cg16814680 chr8:91681699 NA 0.65 8.87 0.48 1.07e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg11764359 chr7:65958608 NA -0.79 -12.0 -0.59 9.01e-27 Aortic root size; CESC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg11663144 chr21:46675770 NA -0.48 -6.61 -0.38 2.05e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs796364 0.813 rs4672686 chr2:201065044 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.58 5.61 0.33 5.22e-8 Schizophrenia; CESC cis rs763121 0.853 rs35565791 chr22:39063011 C/A cg06544989 chr22:39130855 UNC84B 0.48 8.4 0.46 2.69e-15 Menopause (age at onset); CESC cis rs7084402 0.967 rs1658446 chr10:60314183 A/C cg07615347 chr10:60278583 BICC1 0.61 9.59 0.51 7.04e-19 Refractive error; CESC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg21782813 chr7:2030301 MAD1L1 0.41 5.87 0.34 1.29e-8 Bipolar disorder and schizophrenia; CESC trans rs5763662 1.000 rs5763854 chr22:30577589 A/G cg23513814 chr17:72857430 GRIN2C -0.53 -6.05 -0.35 4.81e-9 LDL cholesterol levels;LDL cholesterol; CESC cis rs13191362 0.935 rs7767254 chr6:162954674 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.76 7.37 0.41 2.13e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9467711 0.606 rs2073531 chr6:26375256 A/G cg12826209 chr6:26865740 GUSBL1 0.65 5.35 0.31 1.88e-7 Autism spectrum disorder or schizophrenia; CESC cis rs10426930 0.621 rs6510833 chr19:5008399 G/A cg18115693 chr19:4968519 KDM4B -0.52 -5.09 -0.3 6.91e-7 Monocyte percentage of white cells; CESC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg09491104 chr22:46646882 C22orf40 -0.49 -5.96 -0.34 8.16e-9 LDL cholesterol;Cholesterol, total; CESC cis rs9858542 0.903 rs11917431 chr3:49644012 C/T cg07274523 chr3:49395745 GPX1 0.66 8.45 0.46 2e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg19592336 chr6:28129416 ZNF389 0.46 6.81 0.39 6.58e-11 Cardiac Troponin-T levels; CESC cis rs12478296 0.591 rs6746311 chr2:243001279 A/G cg06360820 chr2:242988706 NA -0.62 -8.19 -0.45 1.12e-14 Obesity-related traits; CESC cis rs17533156 0.525 rs77932036 chr17:75207586 T/G cg11416367 chr17:75137675 SEC14L1 0.71 7.44 0.42 1.39e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs3820928 0.874 rs6706802 chr2:227850776 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -5.29 -0.31 2.59e-7 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18283712 chr14:57735581 MUDENG;EXOC5 0.62 7.72 0.43 2.39e-13 Gut microbiome composition (summer); CESC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg26818010 chr10:134567672 INPP5A -0.87 -10.74 -0.55 1.46e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs11677370 0.533 rs12711971 chr2:3820821 G/C cg17052675 chr2:3827356 NA -0.45 -5.97 -0.34 7.45e-9 Type 2 diabetes; CESC cis rs11190604 1.000 rs2298074 chr10:102247526 G/C cg07080220 chr10:102295463 HIF1AN 0.58 5.16 0.3 4.8e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs17407555 0.518 rs16891234 chr4:9946163 A/G cg00071950 chr4:10020882 SLC2A9 -0.65 -6.83 -0.39 5.73e-11 Schizophrenia (age at onset); CESC cis rs7829975 0.511 rs2980426 chr8:8145609 T/C cg08975724 chr8:8085496 FLJ10661 0.41 5.03 0.3 9.04e-7 Mood instability; CESC cis rs7527798 0.592 rs1323722 chr1:207823405 C/T cg21110645 chr1:207815933 NA -0.33 -5.7 -0.33 3.18e-8 Erythrocyte sedimentation rate; CESC cis rs2412459 0.611 rs4924402 chr15:40245754 C/T cg25407064 chr15:40226267 EIF2AK4 -0.54 -6.14 -0.35 3.01e-9 Response to haloperidol in psychosis; CESC cis rs116095464 0.681 rs10060016 chr5:241100 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.27 0.31 2.9e-7 Breast cancer; CESC cis rs6831352 0.744 rs2602847 chr4:100025963 T/C cg12011299 chr4:100065546 ADH4 0.6 6.6 0.38 2.23e-10 Alcohol dependence; CESC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg24846343 chr22:24311635 DDTL 0.59 9.8 0.52 1.52e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.07 0.3 7.32e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 1.000 rs1404147 chr7:65264524 C/T cg12463550 chr7:65579703 CRCP 0.71 5.96 0.34 7.96e-9 Diabetic kidney disease; CESC cis rs7116495 0.867 rs4378421 chr11:71761996 T/C cg18441811 chr11:71824068 C11orf51 -0.91 -5.42 -0.32 1.37e-7 Severe influenza A (H1N1) infection; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13649253 chr19:13198798 NFIX -0.42 -6.77 -0.38 8.28e-11 Gambling; CESC cis rs796364 0.806 rs34582889 chr2:201010527 A/G cg23649088 chr2:200775458 C2orf69 -0.58 -5.71 -0.33 3.07e-8 Schizophrenia; CESC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg07677032 chr17:61819896 STRADA 0.4 5.03 0.3 8.87e-7 Height; CESC cis rs68170813 0.559 rs78404515 chr7:106909126 G/A cg02696742 chr7:106810147 HBP1 -0.52 -5.07 -0.3 7.42e-7 Coronary artery disease; CESC cis rs4332037 0.539 rs4470910 chr7:2071723 C/T cg02743256 chr7:2109353 MAD1L1 -0.48 -5.05 -0.3 8.26e-7 Bipolar disorder; CESC cis rs3106136 0.967 rs17310526 chr4:95222227 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.73 -0.38 1.02e-10 Capecitabine sensitivity; CESC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.75 -10.17 -0.53 9.89e-21 Mean platelet volume; CESC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg18240062 chr17:79603768 NPLOC4 0.72 10.27 0.53 4.71e-21 Eye color traits; CESC cis rs2414059 0.525 rs58368325 chr15:50971539 C/A cg08437265 chr15:50716283 USP8 0.42 5.36 0.31 1.78e-7 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22998206 chr12:49239429 DDX23 -0.67 -7.46 -0.42 1.24e-12 Gut microbiome composition (summer); CESC trans rs2154294 0.625 rs72672573 chr14:42631039 C/T cg07368857 chr3:71276336 FOXP1 -0.32 -6.05 -0.35 5.01e-9 Alcoholism (12-month weekly alcohol consumption); CESC cis rs3857067 0.773 rs2865344 chr4:95103040 C/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.01 -0.48 4.22e-17 QT interval; CESC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.12 0.35 3.42e-9 Bipolar disorder; CESC cis rs3806843 0.735 rs2530241 chr5:140054485 C/T cg16179182 chr5:140090404 VTRNA1-1 0.41 5.41 0.32 1.42e-7 Depressive symptoms (multi-trait analysis); CESC cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg25019033 chr10:957182 NA -0.57 -6.38 -0.37 7.76e-10 Eosinophil percentage of granulocytes; CESC cis rs2354432 0.607 rs1530335 chr1:146685288 T/C cg25205988 chr1:146714368 CHD1L 1.15 8.65 0.47 4.98e-16 Mitochondrial DNA levels; CESC cis rs68170813 0.559 rs1548524 chr7:106944563 G/T cg02696742 chr7:106810147 HBP1 0.52 5.09 0.3 6.66e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10689147 chr6:43336734 ZNF318 0.55 6.12 0.35 3.27e-9 Gut microbiome composition (summer); CESC cis rs8002861 0.665 rs2065926 chr13:44422371 A/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.4 -5.26 -0.31 2.99e-7 Leprosy; CESC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg22823121 chr1:150693482 HORMAD1 0.36 5.04 0.3 8.78e-7 Melanoma; CESC cis rs6142102 0.602 rs2268086 chr20:32648738 C/T cg08999081 chr20:33150536 PIGU -0.33 -5.13 -0.3 5.72e-7 Skin pigmentation; CESC cis rs7824557 0.564 rs2736290 chr8:11234298 C/T cg21775007 chr8:11205619 TDH -0.55 -8.1 -0.45 1.97e-14 Retinal vascular caliber; CESC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg05776053 chr2:74358815 NA 0.42 5.22 0.31 3.62e-7 Gestational age at birth (maternal effect); CESC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC cis rs6740322 1.000 rs6756736 chr2:43558743 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.59 -6.37 -0.36 8.37e-10 Coronary artery disease; CESC cis rs7089973 0.604 rs11196936 chr10:116588630 C/T cg25233709 chr10:116636983 FAM160B1 0.38 5.9 0.34 1.12e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1018836 0.847 rs4735226 chr8:91569238 T/A cg16814680 chr8:91681699 NA -0.72 -10.29 -0.53 4.01e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs36051895 0.659 rs12336577 chr9:5063690 T/A cg02405213 chr9:5042618 JAK2 -0.51 -6.17 -0.35 2.52e-9 Pediatric autoimmune diseases; CESC cis rs660498 0.507 rs34773871 chr10:27727645 G/A cg08398567 chr10:27609333 NA 0.42 5.65 0.33 4.06e-8 Asthma (childhood onset); CESC cis rs7949030 0.588 rs2428549 chr11:62312394 A/G cg11742103 chr11:62369870 EML3;MTA2 0.57 8.67 0.47 4.35e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg22467129 chr15:76604101 ETFA 0.36 5.2 0.3 3.99e-7 Blood metabolite levels; CESC cis rs7219021 0.926 rs68169424 chr17:46851676 T/C cg16584676 chr17:46985605 UBE2Z -0.52 -5.87 -0.34 1.3e-8 Schizophrenia or bipolar disorder; CESC cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg16339924 chr4:17578868 LAP3 0.59 7.18 0.4 6.89e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.42 -6.95 -0.39 2.78e-11 Personality dimensions; CESC cis rs1707322 0.682 rs28490344 chr1:46197948 C/T cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7107174 0.901 rs1055248 chr11:77925573 T/C cg02023728 chr11:77925099 USP35 0.48 6.67 0.38 1.51e-10 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16489582 chr16:28223388 XPO6 -0.57 -6.77 -0.38 8.43e-11 Gut microbiome composition (summer); CESC cis rs7599312 1.000 rs7599312 chr2:213413231 C/T cg20637307 chr2:213403960 ERBB4 0.43 5.38 0.31 1.61e-7 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12476592 0.602 rs7608470 chr2:63691478 T/C cg17519650 chr2:63277830 OTX1 -0.48 -5.35 -0.31 1.94e-7 Childhood ear infection; CESC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg25036284 chr2:26402008 FAM59B -0.79 -9.27 -0.49 6.83e-18 Gut microbiome composition (summer); CESC cis rs13223928 0.542 rs12540595 chr7:3131792 G/A cg19214707 chr7:3157722 NA -0.4 -5.62 -0.33 4.85e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs7927592 0.731 rs10896350 chr11:68386373 A/C cg01657329 chr11:68192670 LRP5 -0.47 -6.1 -0.35 3.69e-9 Total body bone mineral density; CESC cis rs7937682 0.883 rs472465 chr11:111468962 C/T cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06895436 chr8:82434543 NA -0.58 -6.17 -0.35 2.48e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs7851660 0.933 rs13302470 chr9:100615553 A/G cg13688889 chr9:100608707 NA -0.69 -10.57 -0.54 4.92e-22 Strep throat; CESC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg18351406 chr4:77819688 ANKRD56 0.54 6.67 0.38 1.47e-10 Emphysema distribution in smoking; CESC cis rs3820068 0.581 rs72645893 chr1:15930943 C/G cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs2204008 0.806 rs35534445 chr12:38279093 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.34 0.36 1e-9 Bladder cancer; CESC cis rs714031 0.867 rs5750868 chr22:40063012 G/A cg21377881 chr22:40064566 CACNA1I -0.39 -6.39 -0.37 7.43e-10 Schizophrenia; CESC cis rs3820068 0.603 rs7529759 chr1:15977877 A/G cg16988262 chr1:15930761 NA 0.33 5.36 0.31 1.81e-7 Systolic blood pressure; CESC cis rs12136530 0.593 rs12121189 chr1:19740421 G/A cg01832549 chr1:19774989 CAPZB -0.43 -6.13 -0.35 3.09e-9 Lead levels in blood; CESC cis rs8114671 0.562 rs6119545 chr20:33522869 T/C cg07148914 chr20:33460835 GGT7 0.46 6.13 0.35 3.19e-9 Height; CESC cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg05347473 chr6:146136440 FBXO30 0.58 7.33 0.41 2.84e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7267979 1.000 rs4815411 chr20:25350223 A/G cg08601574 chr20:25228251 PYGB -0.38 -5.49 -0.32 9.26e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs34779708 0.931 rs4934702 chr10:35323074 T/C cg03585969 chr10:35415529 CREM 0.75 9.88 0.52 8.12e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg26408565 chr15:76604113 ETFA -0.41 -5.93 -0.34 9.46e-9 Blood metabolite levels; CESC cis rs6430585 0.941 rs7589832 chr2:136504101 A/C cg07169764 chr2:136633963 MCM6 0.99 12.74 0.62 2.62e-29 Corneal structure; CESC cis rs763121 0.853 rs2294296 chr22:39053049 T/C cg14440974 chr22:39074834 NA -0.4 -5.42 -0.32 1.34e-7 Menopause (age at onset); CESC trans rs17685 0.753 rs13240967 chr7:75658197 C/T cg19862616 chr7:65841803 NCRNA00174 -0.84 -12.47 -0.61 2.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs748404 0.660 rs518288 chr15:43763999 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.51 0.42 9.18e-13 Lung cancer; CESC cis rs977987 0.742 rs34624768 chr16:75331572 G/A cg03315344 chr16:75512273 CHST6 0.38 5.47 0.32 1.06e-7 Dupuytren's disease; CESC cis rs10392 0.543 rs2867240 chr20:37538354 C/T cg27552599 chr20:37590471 DHX35 0.39 5.65 0.33 4.08e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg27588902 chr6:42928151 GNMT -0.28 -5.17 -0.3 4.53e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg19717773 chr7:2847554 GNA12 -0.56 -8.69 -0.47 3.93e-16 Height; CESC cis rs8038465 0.592 rs1542579 chr15:73935897 A/G cg15420318 chr15:73925796 NPTN 0.51 7.14 0.4 8.99e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7017914 0.967 rs1471114 chr8:71675547 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs9399137 0.507 rs6569986 chr6:135311641 T/C cg24558204 chr6:135376177 HBS1L 0.72 10.08 0.53 1.92e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03269368 chr19:19431604 KIAA0892;SF4 0.53 6.37 0.36 8.14e-10 Gut microbiome composition (summer); CESC cis rs6460942 0.818 rs73299043 chr7:12251595 C/G cg06484146 chr7:12443880 VWDE -0.56 -5.67 -0.33 3.66e-8 Coronary artery disease; CESC cis rs7927771 0.524 rs7111576 chr11:47787445 G/A cg18512352 chr11:47633146 NA 0.34 5.24 0.31 3.22e-7 Subjective well-being; CESC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg11764359 chr7:65958608 NA 0.69 9.57 0.51 7.85e-19 Aortic root size; CESC cis rs11155671 0.530 rs6557133 chr6:150195384 G/T cg09699651 chr6:150184138 LRP11 0.42 5.54 0.32 7.35e-8 Testicular germ cell tumor; CESC cis rs35110281 0.682 rs162379 chr21:44925334 A/G cg04455712 chr21:45112962 RRP1B -0.33 -5.27 -0.31 2.83e-7 Mean corpuscular volume; CESC cis rs1005277 0.505 rs200939 chr10:38139483 T/C cg00409905 chr10:38381863 ZNF37A -0.55 -7.6 -0.42 5.08e-13 Extrinsic epigenetic age acceleration; CESC cis rs7605827 0.930 rs4571032 chr2:15685038 A/G cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs7542091 0.669 rs7540534 chr1:210044824 A/T cg22029157 chr1:209979665 IRF6 0.5 7.98 0.44 4.32e-14 Monobrow; CESC cis rs7640424 0.620 rs34910554 chr3:107816733 C/T cg09227934 chr3:107805635 CD47 -0.46 -5.69 -0.33 3.34e-8 Body mass index; CESC cis rs7605827 0.930 rs11694485 chr2:15676154 C/T cg19274914 chr2:15703543 NA 0.38 6.78 0.38 7.69e-11 Educational attainment (years of education); CESC cis rs7605827 0.930 rs2287274 chr2:15658577 T/C cg19274914 chr2:15703543 NA 0.32 5.66 0.33 3.88e-8 Educational attainment (years of education); CESC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg24642844 chr7:1081250 C7orf50 -0.76 -9.26 -0.49 7.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6539267 0.741 rs35816179 chr12:106693710 T/C cg00173435 chr12:106696525 TCP11L2 0.69 8.18 0.45 1.18e-14 Tourette syndrome; CESC cis rs4588572 0.643 rs35299318 chr5:77668322 A/C cg11547950 chr5:77652471 NA 0.44 5.58 0.32 5.84e-8 Triglycerides; CESC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg19717773 chr7:2847554 GNA12 -0.51 -7.57 -0.42 6.05e-13 Height; CESC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg00106254 chr7:1943704 MAD1L1 -0.48 -6.01 -0.35 6.28e-9 Bipolar disorder and schizophrenia; CESC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Depression; CESC cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.34 0.31 2.01e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1045714 0.895 rs73035504 chr7:2642878 G/A cg20813462 chr7:2646259 IQCE 0.65 5.67 0.33 3.66e-8 Urate levels in lean individuals; CESC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg03351412 chr1:154909251 PMVK 0.69 9.32 0.5 4.71e-18 Prostate cancer; CESC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg03351412 chr1:154909251 PMVK 0.58 7.55 0.42 7.15e-13 Prostate cancer; CESC cis rs782590 0.902 rs782595 chr2:55845596 C/G cg18811423 chr2:55921094 PNPT1 0.81 13.01 0.62 3.07e-30 Metabolic syndrome; CESC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.16 0.4 7.99e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6545883 0.895 rs796597 chr2:61681060 A/G cg15711740 chr2:61764176 XPO1 -0.4 -5.2 -0.3 4.06e-7 Tuberculosis; CESC cis rs2011503 1.000 rs4808970 chr19:19651140 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC cis rs8141529 0.711 rs5752797 chr22:29179998 C/T cg02153584 chr22:29168773 CCDC117 0.47 5.19 0.3 4.26e-7 Lymphocyte counts; CESC cis rs71636778 0.543 rs75305560 chr1:27242521 T/G cg12203394 chr1:27248618 NUDC 0.66 5.55 0.32 6.85e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg09177884 chr7:1199841 ZFAND2A -0.5 -6.3 -0.36 1.24e-9 Longevity;Endometriosis; CESC trans rs61931739 0.500 rs11053273 chr12:34547255 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC cis rs4523957 0.928 rs216189 chr17:2187401 A/G cg16513277 chr17:2031491 SMG6 -0.59 -7.95 -0.44 5.35e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26494424 chr12:124118326 EIF2B1;GTF2H3 -0.44 -6.06 -0.35 4.75e-9 Fibrinogen levels; CESC cis rs7267979 0.844 rs6115188 chr20:25432170 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.82 0.67 1.38e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs709400 1.000 rs3915733 chr14:104147353 G/A cg24130564 chr14:104152367 KLC1 -0.43 -5.48 -0.32 9.93e-8 Body mass index; CESC cis rs9486715 0.867 rs2499775 chr6:97007340 C/T cg06623918 chr6:96969491 KIAA0776 -0.95 -15.11 -0.68 1.22e-37 Headache; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04257877 chr7:66309953 LOC729156 0.61 6.63 0.38 1.86e-10 Gut microbiome composition (summer); CESC cis rs16867321 0.627 rs6759191 chr2:181573120 A/G cg23363182 chr2:181467187 NA 0.43 6.31 0.36 1.14e-9 Obesity; CESC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg14159672 chr1:205819179 PM20D1 0.82 12.83 0.62 1.23e-29 Menarche (age at onset); CESC cis rs561341 0.941 rs2428338 chr17:30299629 T/C cg00745463 chr17:30367425 LRRC37B -0.67 -6.68 -0.38 1.39e-10 Hip circumference adjusted for BMI; CESC cis rs116095464 0.558 rs10077076 chr5:231940 C/T cg22857025 chr5:266934 NA -1.29 -18.53 -0.75 9.59e-50 Breast cancer; CESC cis rs66573146 0.572 rs55740475 chr4:6954092 C/G cg00086871 chr4:6988644 TBC1D14 1.05 6.99 0.39 2.26e-11 Granulocyte percentage of myeloid white cells; CESC cis rs920590 0.758 rs1907799 chr8:19664668 A/G cg01411142 chr8:19674711 INTS10 -0.5 -5.85 -0.34 1.43e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.07 0.3 7.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs75477785 0.590 rs11119384 chr1:210160689 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.89 6.01 0.35 6.09e-9 Cleft lip with or without cleft palate; CESC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg27165867 chr14:105738592 BRF1 0.42 5.07 0.3 7.66e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7089973 0.872 rs7074729 chr10:116632257 C/G cg23260525 chr10:116636907 FAM160B1 0.37 6.15 0.35 2.84e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg00149659 chr3:10157352 C3orf10 1.01 12.53 0.61 1.33e-28 Alzheimer's disease; CESC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg24675658 chr1:53192096 ZYG11B -0.66 -9.13 -0.49 1.78e-17 Monocyte count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg20980112 chr1:155108432 RAG1AP1 -0.52 -6.61 -0.38 2.11e-10 Ulcerative colitis; CESC cis rs2228479 0.718 rs62054253 chr16:89896932 T/C cg04013166 chr16:89971882 TCF25 0.72 5.71 0.33 3.01e-8 Skin colour saturation; CESC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg25072359 chr17:41440525 NA 0.5 6.46 0.37 4.89e-10 Menopause (age at onset); CESC cis rs7824557 0.527 rs10109537 chr8:11239640 C/T cg21775007 chr8:11205619 TDH -0.52 -7.79 -0.43 1.53e-13 Retinal vascular caliber; CESC cis rs533123 0.818 rs556408 chr1:29166323 C/A cg08366446 chr1:29138936 OPRD1 0.5 5.88 0.34 1.26e-8 Schizophrenia; CESC cis rs11864453 0.713 rs9925763 chr16:72142595 C/A cg16558253 chr16:72132732 DHX38 -0.54 -8.55 -0.46 9.99e-16 Fibrinogen levels; CESC cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg21132104 chr15:45694354 SPATA5L1 -0.83 -11.3 -0.57 2.06e-24 Homoarginine levels; CESC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg14196790 chr5:131705035 SLC22A5 0.33 5.31 0.31 2.3e-7 Breast cancer; CESC cis rs16867321 0.588 rs1919156 chr2:181456978 C/T cg23363182 chr2:181467187 NA -0.51 -7.57 -0.42 6.06e-13 Obesity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22520562 chr4:82392859 RASGEF1B -0.44 -6.03 -0.35 5.59e-9 Fibrinogen levels; CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg26668828 chr6:292823 DUSP22 0.71 9.52 0.5 1.17e-18 Menopause (age at onset); CESC cis rs941873 0.805 rs10762860 chr10:81117794 C/G cg08514558 chr10:81106712 PPIF 0.34 5.9 0.34 1.13e-8 Height; CESC cis rs11792861 0.566 rs966466 chr9:111851333 T/A cg05043794 chr9:111880884 C9orf5 -0.29 -5.13 -0.3 5.62e-7 Menarche (age at onset); CESC cis rs4704187 0.687 rs6885071 chr5:74460045 A/G cg03227963 chr5:74354835 NA 0.29 5.32 0.31 2.25e-7 Response to amphetamines; CESC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg25517755 chr10:38738941 LOC399744 -0.44 -5.74 -0.33 2.57e-8 Extrinsic epigenetic age acceleration; CESC cis rs6446731 0.593 rs2530601 chr4:3272378 C/G cg08886695 chr4:3369023 RGS12 -0.37 -5.32 -0.31 2.23e-7 Mean platelet volume; CESC cis rs6987853 0.931 rs2923444 chr8:42397004 C/T cg09913449 chr8:42400586 C8orf40 0.39 6.13 0.35 3.15e-9 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09418519 chr4:15683124 LOC285550 0.62 7.09 0.4 1.2e-11 Gut microbiome composition (summer); CESC cis rs9300255 0.602 rs1716165 chr12:123648881 C/T cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.16e-16 Neutrophil percentage of white cells; CESC cis rs8180040 0.726 rs7628747 chr3:47001990 A/T cg27129171 chr3:47204927 SETD2 0.69 10.01 0.52 3.22e-20 Colorectal cancer; CESC cis rs7917772 0.582 rs10786691 chr10:104364652 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 5.66 0.33 4.02e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs10905065 0.895 rs1567707 chr10:5853817 G/C cg11519256 chr10:5708881 ASB13 -0.41 -5.26 -0.31 2.95e-7 Menopause (age at onset); CESC cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg25208724 chr1:156163844 SLC25A44 1.01 19.18 0.76 4.95e-52 Testicular germ cell tumor; CESC trans rs11148252 0.574 rs9536247 chr13:53279542 T/C cg18335740 chr13:41363409 SLC25A15 0.53 7.16 0.4 7.78e-12 Lewy body disease; CESC cis rs9916302 0.904 rs4794814 chr17:37696852 G/A cg07936489 chr17:37558343 FBXL20 -0.8 -11.52 -0.58 3.68e-25 Glomerular filtration rate (creatinine); CESC cis rs9814567 0.793 rs55940445 chr3:134306064 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.05 0.35 4.79e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs13336428 0.730 rs28653458 chr16:1525850 T/C cg08008072 chr16:1524255 CLCN7 -0.73 -12.39 -0.61 4.13e-28 Bone mineral density; CESC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg26752003 chr8:145688521 CYHR1 -0.55 -7.32 -0.41 2.95e-12 Age at first birth; CESC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.45 -0.32 1.17e-7 Developmental language disorder (linguistic errors); CESC cis rs9913156 0.793 rs9436 chr17:4574751 T/A cg00122941 chr17:4613640 ARRB2 0.87 10.06 0.53 2.27e-20 Lymphocyte counts; CESC cis rs7833986 0.501 rs2976036 chr8:57031721 G/T cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.41 0.32 1.42e-7 Height; CESC cis rs61935443 0.614 rs61935662 chr12:95313296 A/G cg21533806 chr12:95267307 NA 0.48 5.18 0.3 4.42e-7 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09268800 chr1:153914384 DENND4B 0.44 6.16 0.35 2.76e-9 Fibrinogen levels; CESC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -5.72 -0.33 2.85e-8 Extrinsic epigenetic age acceleration; CESC cis rs116095464 0.614 rs62344292 chr5:244630 G/A cg20965017 chr5:231967 SDHA -0.47 -5.38 -0.31 1.65e-7 Breast cancer; CESC cis rs7772486 0.686 rs1337839 chr6:146010239 A/G cg23711669 chr6:146136114 FBXO30 -0.89 -12.64 -0.61 5.62e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs1401999 0.724 rs1016752 chr3:183665062 C/G cg01324343 chr3:183735012 ABCC5 -0.56 -9.96 -0.52 4.62e-20 Anterior chamber depth; CESC cis rs4319547 0.915 rs11058402 chr12:122981053 A/G cg23029597 chr12:123009494 RSRC2 -0.5 -5.43 -0.32 1.26e-7 Body mass index; CESC cis rs3008870 1.000 rs12117131 chr1:67451922 C/T cg02640540 chr1:67518911 SLC35D1 -0.52 -5.59 -0.33 5.5e-8 Lymphocyte percentage of white cells; CESC cis rs3733585 0.638 rs6414766 chr4:9956474 G/A cg02734326 chr4:10020555 SLC2A9 -0.41 -5.81 -0.34 1.74e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2204008 0.840 rs11181795 chr12:38401129 A/G cg26384229 chr12:38710491 ALG10B 0.72 10.94 0.56 3.12e-23 Bladder cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01068102 chr11:65620199 SNX32 0.47 6.55 0.37 2.95e-10 Fibrinogen levels; CESC cis rs9640161 0.711 rs3800781 chr7:150027324 T/A cg17279839 chr7:150038598 RARRES2 0.43 5.17 0.3 4.61e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs11250098 0.574 rs4240672 chr8:10767917 G/A cg06636001 chr8:8085503 FLJ10661 -0.49 -6.02 -0.35 5.79e-9 Morning vs. evening chronotype; CESC cis rs7165102 1.000 rs7496335 chr15:65758868 A/T cg11441148 chr15:65824328 PTPLAD1 0.32 5.26 0.31 2.91e-7 Mean corpuscular hemoglobin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08857039 chr6:42110396 C6orf132 0.56 6.97 0.39 2.48e-11 Gut microbiome composition (summer); CESC cis rs1461503 0.934 rs930983 chr11:122834414 A/G cg27398637 chr11:122830231 C11orf63 -0.49 -6.95 -0.39 2.86e-11 Menarche (age at onset); CESC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg23708337 chr7:1209742 NA 0.55 5.46 0.32 1.07e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs36051895 0.553 rs12338854 chr9:5057568 G/C cg02405213 chr9:5042618 JAK2 -0.43 -5.28 -0.31 2.66e-7 Pediatric autoimmune diseases; CESC cis rs9325144 0.560 rs7980635 chr12:38668355 G/T cg26384229 chr12:38710491 ALG10B -0.6 -8.5 -0.46 1.44e-15 Morning vs. evening chronotype; CESC cis rs9291683 0.530 rs11723970 chr4:9980462 T/C cg11266682 chr4:10021025 SLC2A9 0.62 12.65 0.61 5.16e-29 Bone mineral density; CESC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg09509183 chr1:209979624 IRF6 0.6 5.99 0.35 6.69e-9 Cleft lip with or without cleft palate; CESC cis rs2760061 0.819 rs708115 chr1:228198046 C/T cg02753203 chr1:228287806 NA 0.53 7.89 0.44 8.14e-14 Diastolic blood pressure; CESC cis rs11587400 0.679 rs2014836 chr1:115080875 A/G cg12756093 chr1:115239321 AMPD1 0.43 5.86 0.34 1.36e-8 Autism; CESC cis rs2072499 1.000 rs2253809 chr1:156172125 T/C cg25208724 chr1:156163844 SLC25A44 0.98 18.11 0.74 3.06e-48 Testicular germ cell tumor; CESC cis rs9913156 0.515 rs11658808 chr17:4577112 C/T cg00122941 chr17:4613640 ARRB2 -0.61 -7.71 -0.43 2.61e-13 Lymphocyte counts; CESC cis rs7100689 0.646 rs1047952 chr10:82126808 C/G cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09472211 chr10:89622126 PTEN;KILLIN 0.59 6.9 0.39 3.83e-11 Gut microbiome composition (summer); CESC cis rs2742234 0.955 rs2075910 chr10:43614230 G/A cg07801480 chr10:43725741 RASGEF1A 0.38 5.27 0.31 2.82e-7 Hirschsprung disease; CESC cis rs1059312 0.545 rs7312683 chr12:129280105 T/C cg09035930 chr12:129282057 SLC15A4 0.54 6.83 0.39 5.74e-11 Systemic lupus erythematosus; CESC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg27266027 chr21:40555129 PSMG1 0.45 5.34 0.31 2.05e-7 Cognitive function; CESC trans rs66573146 1.000 rs7686186 chr4:6986094 C/T cg07817883 chr1:32538562 TMEM39B 1.48 9.1 0.49 2.16e-17 Granulocyte percentage of myeloid white cells; CESC cis rs2070488 0.965 rs13079145 chr3:38517992 T/G cg24069376 chr3:38537580 EXOG 0.48 8.82 0.48 1.52e-16 Electrocardiographic conduction measures; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01857591 chr8:81083836 TPD52 -0.47 -6.16 -0.35 2.67e-9 Fibrinogen levels; CESC cis rs2963155 0.518 rs174048 chr5:142650404 T/C cg17617527 chr5:142782415 NR3C1 0.86 7.62 0.42 4.41e-13 Breast cancer; CESC cis rs7590720 1.000 rs7559031 chr2:216902583 A/G cg12620499 chr2:216877984 MREG 0.91 12.38 0.61 4.23e-28 Alcohol dependence; CESC cis rs9467711 0.606 rs9379897 chr6:26601526 T/C cg12826209 chr6:26865740 GUSBL1 0.67 6.06 0.35 4.68e-9 Autism spectrum disorder or schizophrenia; CESC cis rs77741769 0.571 rs12580949 chr12:121298164 A/G cg02419362 chr12:121203948 SPPL3 0.34 5.59 0.32 5.6e-8 Mean corpuscular volume; CESC cis rs2820292 0.740 rs12137232 chr1:201885446 G/T cg06775570 chr1:201857621 SHISA4 -0.32 -5.28 -0.31 2.67e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs2603127 0.768 rs9870145 chr3:108477874 A/T cg03329597 chr3:108125523 MYH15 0.6 5.35 0.31 1.91e-7 Hemostatic factors and hematological phenotypes; CESC cis rs8067354 0.645 rs2645492 chr17:57875554 A/G cg13753209 chr17:57696993 CLTC -0.59 -6.74 -0.38 1e-10 Hemoglobin concentration; CESC cis rs992157 0.560 rs4674274 chr2:219089131 A/T cg00012203 chr2:219082015 ARPC2 -0.74 -9.9 -0.52 7.06e-20 Colorectal cancer; CESC cis rs40363 0.951 rs72778117 chr16:3531827 T/C cg22508957 chr16:3507546 NAT15 0.73 8.9 0.48 8.91e-17 Tuberculosis; CESC cis rs9815354 0.812 rs73069209 chr3:41939781 G/A cg03022575 chr3:42003672 ULK4 0.71 6.4 0.37 7.01e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs7542091 0.739 rs10863793 chr1:210037420 G/A cg25204440 chr1:209979598 IRF6 0.4 5.24 0.31 3.26e-7 Monobrow; CESC cis rs28647808 1.000 rs35179461 chr9:136270293 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg26408565 chr15:76604113 ETFA -0.37 -5.29 -0.31 2.56e-7 Blood metabolite levels; CESC cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg10523679 chr1:76189770 ACADM -0.61 -6.1 -0.35 3.7e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3767633 0.800 rs2341479 chr1:161885352 C/A cg09175582 chr1:161736000 ATF6 0.68 5.99 0.35 6.75e-9 IgG glycosylation; CESC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg02569458 chr12:86230093 RASSF9 -0.43 -6.5 -0.37 4.05e-10 Major depressive disorder; CESC cis rs1451375 0.617 rs745043 chr7:50543955 T/G cg14593290 chr7:50529359 DDC -0.53 -6.0 -0.35 6.62e-9 Malaria; CESC cis rs8114671 0.562 rs4911447 chr20:33479445 T/A cg24642439 chr20:33292090 TP53INP2 0.44 5.31 0.31 2.38e-7 Height; CESC cis rs1580019 0.587 rs2392069 chr7:32547154 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.39 0.37 7.42e-10 Cognitive ability; CESC cis rs6540556 0.954 rs2076150 chr1:209933540 A/G cg05527609 chr1:210001259 C1orf107 -0.45 -5.63 -0.33 4.66e-8 Red blood cell count; CESC cis rs7267979 0.833 rs6138556 chr20:25243310 C/T cg08601574 chr20:25228251 PYGB 0.4 5.7 0.33 3.25e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs6570726 0.791 rs952406 chr6:145925616 C/A cg05347473 chr6:146136440 FBXO30 0.5 6.61 0.38 2.11e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.593 rs7000752 chr8:58026980 C/G cg24829409 chr8:58192753 C8orf71 -0.45 -5.76 -0.33 2.34e-8 Developmental language disorder (linguistic errors); CESC cis rs17253792 0.822 rs77741349 chr14:56097462 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.76 5.39 0.31 1.56e-7 Putamen volume; CESC cis rs763014 0.931 rs7199839 chr16:636126 T/C cg09781414 chr16:715207 WDR90 -0.33 -5.04 -0.3 8.57e-7 Height; CESC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg00106254 chr7:1943704 MAD1L1 -0.49 -6.16 -0.35 2.67e-9 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4654899 0.865 rs12131353 chr1:21321163 C/G cg05370193 chr1:21551575 ECE1 0.42 6.26 0.36 1.55e-9 Superior frontal gyrus grey matter volume; CESC cis rs897984 0.721 rs28360557 chr16:30983260 A/C cg00531865 chr16:30841666 NA 0.5 6.85 0.39 5.2e-11 Dementia with Lewy bodies; CESC cis rs2404602 0.647 rs12898416 chr15:77042292 C/G cg23625390 chr15:77176239 SCAPER -0.4 -5.2 -0.3 4e-7 Blood metabolite levels; CESC cis rs6460942 1.000 rs79964328 chr7:12319392 A/C cg06484146 chr7:12443880 VWDE -0.81 -8.78 -0.47 2.13e-16 Coronary artery disease; CESC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg00310523 chr12:86230176 RASSF9 0.35 5.41 0.32 1.43e-7 Major depressive disorder; CESC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg11644478 chr21:40555479 PSMG1 -0.78 -11.42 -0.57 8.11e-25 Cognitive function; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22333733 chr11:31391482 DNAJC24;DCDC1 0.39 6.38 0.36 7.65e-10 Gambling; CESC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg06108461 chr20:60628389 TAF4 -0.8 -12.19 -0.6 1.92e-27 Body mass index; CESC cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg06212747 chr3:49208901 KLHDC8B 0.74 9.74 0.51 2.27e-19 Parkinson's disease; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23713813 chr1:25071889 CLIC4 -0.5 -6.37 -0.36 8.25e-10 Ulcerative colitis; CESC cis rs9388451 0.839 rs3966775 chr6:126067655 C/A cg10911889 chr6:126070802 HEY2 0.42 5.87 0.34 1.3e-8 Brugada syndrome; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24696268 chr4:49526636 NA -0.41 -6.0 -0.35 6.5e-9 Gut microbiota (bacterial taxa); CESC cis rs9926296 0.632 rs7206546 chr16:89799079 C/T cg03388025 chr16:89894329 SPIRE2 -0.29 -5.1 -0.3 6.52e-7 Vitiligo; CESC cis rs6460942 0.908 rs77894875 chr7:12248257 T/C cg06484146 chr7:12443880 VWDE -0.69 -6.86 -0.39 4.71e-11 Coronary artery disease; CESC cis rs4704187 0.687 rs10064409 chr5:74527134 A/G cg03227963 chr5:74354835 NA 0.28 5.04 0.3 8.66e-7 Response to amphetamines; CESC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg09877947 chr5:131593287 PDLIM4 -0.43 -5.25 -0.31 3.17e-7 Acylcarnitine levels; CESC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.87 11.27 0.57 2.42e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg18032046 chr6:28092343 ZSCAN16 -0.42 -5.55 -0.32 6.99e-8 Cardiac Troponin-T levels; CESC cis rs6570726 0.720 rs412623 chr6:145883257 C/A cg05347473 chr6:146136440 FBXO30 0.49 6.35 0.36 9.1e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg10691866 chr7:65817282 TPST1 -0.32 -5.42 -0.32 1.37e-7 Aortic root size; CESC cis rs7078219 0.505 rs7916751 chr10:101285650 T/A cg09788492 chr10:101292477 NKX2-3 0.33 6.28 0.36 1.37e-9 Dental caries; CESC trans rs6952808 1.000 rs6953693 chr7:1886388 C/G cg24247370 chr13:99142703 STK24 -0.41 -6.14 -0.35 2.99e-9 Bipolar disorder and schizophrenia; CESC cis rs56104184 0.723 rs116909499 chr19:49407733 C/T cg21252483 chr19:49399788 TULP2 -0.49 -5.56 -0.32 6.67e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs11122272 0.614 rs78172021 chr1:231525160 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.69 -0.43 2.8e-13 Hemoglobin concentration; CESC cis rs7223966 1.000 rs9908044 chr17:61747032 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.42 0.41 1.55e-12 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg23758822 chr17:41437982 NA 1.03 17.53 0.73 3.37e-46 Menopause (age at onset); CESC cis rs3820928 0.874 rs10166736 chr2:227900419 C/T cg05526886 chr2:227700861 RHBDD1 -0.45 -5.64 -0.33 4.29e-8 Pulmonary function; CESC cis rs826838 1.000 rs9795768 chr12:39012479 T/C cg13010199 chr12:38710504 ALG10B 0.58 8.1 0.45 2.01e-14 Heart rate; CESC cis rs6120849 0.754 rs6120812 chr20:33629427 T/C cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs17376456 0.825 rs28610997 chr5:93248374 T/C cg21475434 chr5:93447410 FAM172A 0.76 6.2 0.36 2.16e-9 Diabetic retinopathy; CESC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg08968635 chr6:28129556 ZNF389 -0.4 -5.3 -0.31 2.46e-7 Depression; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03651904 chr19:2807229 THOP1 0.54 7.25 0.41 4.48e-12 Fibrinogen levels; CESC cis rs7927771 0.524 rs7123952 chr11:47852057 T/C cg18512352 chr11:47633146 NA 0.35 5.4 0.31 1.51e-7 Subjective well-being; CESC cis rs524281 1.000 rs565198 chr11:65913508 A/T cg14036092 chr11:66035641 RAB1B 0.53 6.23 0.36 1.79e-9 Electroencephalogram traits; CESC cis rs7520050 0.771 rs4660882 chr1:46116292 C/T cg03146154 chr1:46216737 IPP 0.52 6.97 0.39 2.55e-11 Red blood cell count;Reticulocyte count; CESC trans rs7726839 0.540 rs3762951 chr5:662613 C/G cg25482853 chr8:67687455 SGK3 0.96 9.84 0.52 1.09e-19 Obesity-related traits; CESC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.77 8.58 0.47 8.32e-16 Alzheimer's disease; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg11222527 chr1:226926964 ITPKB 0.48 6.11 0.35 3.6e-9 Thyroid stimulating hormone; CESC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg20243544 chr17:37824526 PNMT -0.45 -5.48 -0.32 9.91e-8 Glomerular filtration rate (creatinine); CESC cis rs7631605 0.819 rs1392748 chr3:37265313 T/C cg22985146 chr3:37219077 LRRFIP2 -0.34 -5.33 -0.31 2.13e-7 Cerebrospinal P-tau181p levels; CESC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg19622623 chr12:86230825 RASSF9 -0.46 -5.87 -0.34 1.28e-8 Major depressive disorder; CESC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -6.15 -0.35 2.78e-9 Schizophrenia; CESC cis rs362296 0.698 rs3135172 chr4:3258735 A/G cg08886695 chr4:3369023 RGS12 0.43 5.68 0.33 3.57e-8 Parental longevity (mother's age at death); CESC cis rs9863 0.828 rs4765562 chr12:124472571 T/C cg00084347 chr12:124393913 DNAH10 0.27 5.23 0.31 3.4e-7 White blood cell count; CESC cis rs8180040 0.966 rs13059519 chr3:47539969 C/T cg27129171 chr3:47204927 SETD2 0.6 8.92 0.48 7.75e-17 Colorectal cancer; CESC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg03188948 chr7:1209495 NA 0.73 7.05 0.4 1.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs75477785 1.000 rs12078157 chr1:210049901 C/T cg02304930 chr1:210405566 SERTAD4;C1orf133 0.79 5.15 0.3 5.08e-7 Cleft lip with or without cleft palate; CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg18402987 chr7:1209562 NA 0.61 7.13 0.4 9.46e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs7618501 0.602 rs2526743 chr3:50115245 G/A cg21659725 chr3:3221576 CRBN -0.51 -7.03 -0.4 1.7e-11 Intelligence (multi-trait analysis); CESC cis rs1348850 0.874 rs13013752 chr2:178456862 A/G cg23306229 chr2:178417860 TTC30B 0.57 7.44 0.42 1.43e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1448094 0.842 rs7978562 chr12:86451478 A/G cg02569458 chr12:86230093 RASSF9 0.34 5.1 0.3 6.37e-7 Major depressive disorder; CESC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.58 -0.37 2.52e-10 Bipolar disorder; CESC cis rs66561647 0.563 rs4733580 chr8:128932677 G/A cg05480350 chr8:128972681 MIR1205;PVT1 0.4 5.37 0.31 1.7e-7 Hemoglobin concentration; CESC cis rs6432018 1.000 rs11887863 chr2:9739429 G/T cg23886495 chr2:9695866 ADAM17 0.45 5.28 0.31 2.67e-7 Heart rate variability traits; CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg11905131 chr22:24372483 LOC391322 -0.82 -12.38 -0.61 4.47e-28 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs73206853 0.764 rs55913108 chr12:110816507 T/C cg12870014 chr12:110450643 ANKRD13A 0.63 5.23 0.31 3.48e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7210086 0.898 rs61463201 chr17:70636951 C/T cg04206342 chr17:70636940 NA -0.31 -5.48 -0.32 9.7e-8 Ulcerative colitis; CESC cis rs2733201 1.000 rs2114421 chr15:44313055 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.66 -5.93 -0.34 9.18e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs6772849 0.965 rs67790930 chr3:128310036 C/T cg16766828 chr3:128327626 NA -0.31 -5.06 -0.3 7.77e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs12079745 0.793 rs12063863 chr1:169269557 G/A cg09363564 chr1:169337483 NME7;BLZF1 -1.0 -6.04 -0.35 5.12e-9 QT interval; CESC cis rs8044868 0.530 rs7185840 chr16:72102112 A/G cg16558253 chr16:72132732 DHX38 -0.38 -5.91 -0.34 1.06e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs8141529 0.732 rs3788409 chr22:29198151 T/G cg15103426 chr22:29168792 CCDC117 0.7 9.94 0.52 5.45e-20 Lymphocyte counts; CESC cis rs4689592 0.587 rs3822269 chr4:7069901 T/C cg19539972 chr4:7069911 GRPEL1 0.79 9.58 0.51 7.51e-19 Monocyte percentage of white cells; CESC cis rs34779708 0.733 rs12777960 chr10:35541026 C/A cg04310649 chr10:35416472 CREM -0.47 -5.39 -0.31 1.59e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs4642101 0.737 rs9877165 chr3:12828497 C/T cg24848339 chr3:12840334 CAND2 0.36 5.51 0.32 8.6e-8 QRS complex (12-leadsum); CESC cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.56 -6.4 -0.37 6.89e-10 Multiple sclerosis; CESC cis rs28595532 0.702 rs72670252 chr4:119337546 A/C cg21605333 chr4:119757512 SEC24D 1.01 5.58 0.32 5.98e-8 Cannabis dependence symptom count; CESC cis rs11608355 0.545 rs1073780 chr12:109895143 T/C cg05360138 chr12:110035743 NA 0.79 8.25 0.45 7.43e-15 Neuroticism; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10620530 chr9:139922595 C9orf139;ABCA2 -0.41 -6.23 -0.36 1.78e-9 Gambling; CESC cis rs9309473 1.000 rs7598396 chr2:73652628 A/G cg20560298 chr2:73613845 ALMS1 -0.56 -7.33 -0.41 2.86e-12 Metabolite levels; CESC cis rs7017914 0.967 rs6472543 chr8:71664408 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs6088580 0.634 rs6058070 chr20:33103521 G/C cg06115741 chr20:33292138 TP53INP2 0.45 5.74 0.33 2.53e-8 Glomerular filtration rate (creatinine); CESC cis rs3762637 1.000 rs9878699 chr3:122194231 T/A cg24169773 chr3:122142474 KPNA1 -0.54 -6.33 -0.36 1.04e-9 LDL cholesterol levels; CESC cis rs4969178 0.965 rs2292643 chr17:76395421 G/A cg20026190 chr17:76395443 PGS1 0.49 7.73 0.43 2.17e-13 HDL cholesterol levels; CESC cis rs2235642 0.821 rs2281234 chr16:1602938 A/G cg07639376 chr16:1584516 IFT140;TMEM204 -0.31 -5.07 -0.3 7.41e-7 Coronary artery disease; CESC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.07 0.6 5.1e-27 Alzheimer's disease; CESC cis rs8072100 0.967 rs8078880 chr17:45676526 G/C cg08085267 chr17:45401833 C17orf57 0.39 5.08 0.3 7.08e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs2070997 0.756 rs7026988 chr9:133667899 C/T cg11464064 chr9:133710261 ABL1 0.5 5.44 0.32 1.21e-7 Response to amphetamines; CESC cis rs1003719 0.715 rs2835644 chr21:38545610 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.06 -0.44 2.72e-14 Eye color traits; CESC cis rs7044106 0.734 rs12553070 chr9:123485266 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.85 13.84 0.65 3.68e-33 Hip circumference adjusted for BMI; CESC cis rs34779708 0.931 rs59418206 chr10:35331624 G/A cg03585969 chr10:35415529 CREM 0.78 10.23 0.53 6.43e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs6912958 0.781 rs4464759 chr6:88282621 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.75 -0.38 9.22e-11 Monocyte percentage of white cells; CESC cis rs2880765 0.835 rs4842887 chr15:86035810 T/C cg19183879 chr15:85880815 NA -0.25 -5.04 -0.3 8.58e-7 Coronary artery disease; CESC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2625529 0.730 rs1481860 chr15:72241857 T/C cg16672083 chr15:72433130 SENP8 0.42 5.96 0.34 7.88e-9 Red blood cell count; CESC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg27572855 chr1:25598939 RHD 0.5 8.45 0.46 1.99e-15 Erythrocyte sedimentation rate; CESC cis rs4555082 0.957 rs10140586 chr14:105749582 A/G cg10792982 chr14:105748885 BRF1 0.37 5.14 0.3 5.47e-7 Mean platelet volume;Platelet distribution width; CESC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg08499158 chr17:42289980 UBTF -0.56 -6.93 -0.39 3.2e-11 Total body bone mineral density; CESC cis rs6728642 1.000 rs75297860 chr2:97600078 G/A cg26665480 chr2:98280029 ACTR1B -0.81 -6.31 -0.36 1.17e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs2637266 0.935 rs2583055 chr10:78400029 C/T cg18941641 chr10:78392320 NA 0.45 8.65 0.47 5e-16 Pulmonary function; CESC cis rs6542838 0.580 rs1607256 chr2:99543444 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.26 -0.31 3.04e-7 Fear of minor pain; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg01348873 chr3:52349823 DNAH1 0.45 6.31 0.36 1.2e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs3126085 0.825 rs11204938 chr1:152193990 A/G cg26876637 chr1:152193138 HRNR 0.47 5.43 0.32 1.28e-7 Atopic dermatitis; CESC cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg03060546 chr3:49711283 APEH 0.51 6.18 0.35 2.4e-9 Parkinson's disease; CESC cis rs2976388 0.556 rs10956985 chr8:143818750 C/A cg24634471 chr8:143751801 JRK -0.46 -5.04 -0.3 8.52e-7 Urinary tract infection frequency; CESC cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg07755735 chr2:20870362 GDF7 0.4 6.45 0.37 5.28e-10 Abdominal aortic aneurysm; CESC trans rs17685 0.623 rs7782808 chr7:75768645 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 12.41 0.61 3.51e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs2072732 0.716 rs72856433 chr1:2954061 G/A cg03976712 chr1:2946727 NA 0.33 5.59 0.32 5.59e-8 Plateletcrit; CESC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.85 11.3 0.57 2.02e-24 Alzheimer's disease; CESC cis rs12477438 0.765 rs6749059 chr2:99591021 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -10.28 -0.53 4.31e-21 Chronic sinus infection; CESC cis rs193541 0.564 rs62377434 chr5:122340569 C/A cg19412675 chr5:122181750 SNX24 -0.46 -5.39 -0.31 1.58e-7 Glucose homeostasis traits; CESC cis rs3540 0.960 rs8030390 chr15:90943471 C/T cg22089800 chr15:90895588 ZNF774 0.41 5.07 0.3 7.61e-7 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs6088580 0.601 rs6059827 chr20:33016358 C/T cg24642439 chr20:33292090 TP53INP2 0.53 7.03 0.4 1.74e-11 Glomerular filtration rate (creatinine); CESC cis rs9796 0.621 rs7170049 chr15:41484287 C/A cg12426344 chr15:41135900 SPINT1 -0.24 -5.13 -0.3 5.68e-7 Menopause (age at onset); CESC cis rs1062177 1.000 rs2964576 chr5:151150602 T/G cg12924095 chr5:151150029 G3BP1 0.48 6.19 0.36 2.3e-9 Preschool internalizing problems; CESC cis rs10463316 0.817 rs1318783 chr5:150814807 T/G cg03212797 chr5:150827313 SLC36A1 -0.51 -6.63 -0.38 1.85e-10 Metabolite levels (Pyroglutamine); CESC cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg21573476 chr21:45109991 RRP1B -0.5 -6.94 -0.39 2.95e-11 Mean corpuscular volume; CESC cis rs2204008 0.624 rs2320449 chr12:38224190 T/C cg13010199 chr12:38710504 ALG10B 0.53 6.67 0.38 1.51e-10 Bladder cancer; CESC cis rs10392 0.543 rs12626105 chr20:37534582 A/G cg27552599 chr20:37590471 DHX35 0.38 5.41 0.32 1.44e-7 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC trans rs804280 0.517 rs7815179 chr8:11792048 C/G cg15556689 chr8:8085844 FLJ10661 0.52 6.39 0.37 7.33e-10 Myopia (pathological); CESC cis rs2637266 0.703 rs7096185 chr10:78470287 C/T cg18941641 chr10:78392320 NA 0.39 7.16 0.4 7.83e-12 Pulmonary function; CESC cis rs1707322 0.752 rs3811436 chr1:46125880 T/C cg03146154 chr1:46216737 IPP 0.82 11.51 0.58 3.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9359856 0.564 rs56084221 chr6:90365349 T/C cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.35 -0.36 9.29e-10 Bipolar disorder; CESC cis rs7618915 0.679 rs6802320 chr3:52241835 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.43 5.35 0.31 1.93e-7 Bipolar disorder; CESC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg22800045 chr5:56110881 MAP3K1 0.49 5.98 0.34 7.31e-9 Coronary artery disease; CESC cis rs10751667 1.000 rs7396798 chr11:970510 G/T cg20946044 chr11:1010712 AP2A2 -0.43 -5.72 -0.33 2.92e-8 Alzheimer's disease (late onset); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg12229505 chr15:80351983 ZFAND6 -0.48 -6.3 -0.36 1.24e-9 Thyroid stimulating hormone; CESC cis rs2629540 0.765 rs7097177 chr10:126539839 A/G cg08799069 chr10:126477246 METTL10 -0.53 -7.49 -0.42 1.04e-12 Cocaine dependence; CESC trans rs4942242 0.617 rs9590778 chr13:44199007 C/G cg19169023 chr15:41853346 TYRO3 -0.58 -7.44 -0.42 1.42e-12 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6582630 0.537 rs1949610 chr12:38387838 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.02 0.35 5.68e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs2228479 0.702 rs2074963 chr16:89877269 T/C cg06558623 chr16:89946397 TCF25 1.09 8.0 0.44 3.87e-14 Skin colour saturation; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26335430 chr17:73780571 UNK -0.43 -6.05 -0.35 4.9e-9 Gut microbiota (bacterial taxa); CESC cis rs4689388 0.824 rs114669221 chr4:6301459 G/A cg25554036 chr4:6271136 WFS1 0.53 8.73 0.47 2.87e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4810685 0.816 rs1316709 chr20:46407509 C/T cg08288986 chr20:46415360 SULF2 -0.55 -6.83 -0.39 5.89e-11 Attention deficit hyperactivity disorder (time to onset); CESC cis rs2243480 1.000 rs313813 chr7:65503500 C/T cg25894440 chr7:65020034 NA -0.6 -5.06 -0.3 7.7300000000000005e-07 Diabetic kidney disease; CESC cis rs9309473 0.898 rs10170786 chr2:73812988 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -6.46 -0.37 4.96e-10 Metabolite levels; CESC cis rs3857067 0.901 rs4693368 chr4:95046907 G/A cg11021082 chr4:95130006 SMARCAD1 -0.52 -7.78 -0.43 1.65e-13 QT interval; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05270305 chr10:14880273 HSPA14;CDNF -0.46 -6.56 -0.37 2.75e-10 Fibrinogen levels; CESC cis rs62432291 0.681 rs419836 chr6:159659481 C/T cg14500486 chr6:159655392 FNDC1 -0.62 -6.34 -0.36 9.83e-10 Joint mobility (Beighton score); CESC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg22535103 chr8:58192502 C8orf71 -0.65 -6.98 -0.39 2.38e-11 Developmental language disorder (linguistic errors); CESC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg25767906 chr1:53392781 SCP2 -0.51 -6.76 -0.38 8.8e-11 Monocyte count; CESC cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg23422044 chr7:1970798 MAD1L1 -0.48 -5.15 -0.3 5e-7 Bipolar disorder; CESC cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg25019033 chr10:957182 NA -0.59 -6.34 -0.36 9.88e-10 Eosinophil percentage of granulocytes; CESC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg12648201 chr2:27665141 KRTCAP3 -0.28 -5.42 -0.32 1.32e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs7223966 1.000 rs73337598 chr17:61732576 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.56 -0.32 6.58e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs13191362 0.507 rs2803051 chr6:163034979 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.54 -6.89 -0.39 3.97e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9902453 0.740 rs2617884 chr17:28120430 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs9902453 1.000 rs9890886 chr17:28391076 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.87 -0.44 9.09e-14 Coffee consumption (cups per day); CESC cis rs7666738 0.830 rs7672720 chr4:98938760 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.4 0.46 2.75e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7647973 0.580 rs4955432 chr3:49266772 C/T cg03060546 chr3:49711283 APEH 0.52 7.03 0.4 1.76e-11 Menarche (age at onset); CESC cis rs10851478 0.529 rs9920722 chr15:49735112 C/T cg08060515 chr15:49448048 GALK2;COPS2 -0.44 -5.83 -0.34 1.57e-8 Oral cavity cancer; CESC cis rs854765 0.547 rs2955355 chr17:17948475 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.56 -8.0 -0.44 3.85e-14 Total body bone mineral density; CESC cis rs7605827 0.930 rs2287260 chr2:15624810 T/C cg19274914 chr2:15703543 NA 0.33 5.95 0.34 8.34e-9 Educational attainment (years of education); CESC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg08968635 chr6:28129556 ZNF389 0.41 5.51 0.32 8.4e-8 Depression; CESC cis rs1215050 0.740 rs13134479 chr4:99067723 G/A cg17366294 chr4:99064904 C4orf37 0.4 5.16 0.3 4.9e-7 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2635047 0.837 rs2571009 chr18:44650279 A/G cg19077165 chr18:44547161 KATNAL2 -0.47 -6.65 -0.38 1.66e-10 Educational attainment; CESC cis rs4664293 0.967 rs1006192 chr2:160567589 G/T cg08347373 chr2:160653686 CD302 -0.32 -5.05 -0.3 8.26e-7 Monocyte percentage of white cells; CESC cis rs2290720 0.813 rs1979269 chr12:101755380 C/G cg22051763 chr12:101673672 UTP20 -0.42 -5.17 -0.3 4.59e-7 Brain structure (hippocampal volume); CESC cis rs6540556 0.768 rs6692012 chr1:209935490 A/G cg05527609 chr1:210001259 C1orf107 -0.44 -5.55 -0.32 6.87e-8 Red blood cell count; CESC cis rs7586673 0.866 rs7579662 chr2:161915810 G/A cg22496339 chr2:162101262 NA 0.5 6.57 0.37 2.69e-10 Intelligence (multi-trait analysis); CESC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg14820908 chr5:178986412 RUFY1 0.5 7.73 0.43 2.27e-13 Lung cancer; CESC cis rs10744422 0.925 rs897391 chr12:123326374 G/A cg25930673 chr12:123319894 HIP1R -0.65 -5.28 -0.31 2.72e-7 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04825775 chr5:176981128 FAM193B -0.44 -6.03 -0.35 5.37e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11122272 0.766 rs2486732 chr1:231531476 A/C cg06096015 chr1:231504339 EGLN1 0.41 5.8 0.34 1.91e-8 Hemoglobin concentration; CESC cis rs7524258 0.868 rs6577428 chr1:7314655 C/T cg07173049 chr1:7289937 CAMTA1 -0.39 -5.82 -0.34 1.65e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs372883 0.648 rs368322 chr21:30717151 C/T cg24692254 chr21:30365293 RNF160 -0.51 -6.39 -0.37 7.42e-10 Pancreatic cancer; CESC cis rs977987 0.806 rs12449170 chr16:75463012 C/T cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16097330 chr5:171615472 STK10 -0.46 -6.6 -0.38 2.27e-10 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11301069 chr17:8027502 HES7 0.57 7.0 0.4 2.06e-11 Gut microbiome composition (summer); CESC cis rs9581857 0.556 rs9581863 chr13:28040171 A/G cg22138327 chr13:27999177 GTF3A 0.64 7.1 0.4 1.16e-11 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg02079420 chr8:82753780 SNX16 0.54 7.42 0.41 1.64e-12 Diastolic blood pressure; CESC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg27170947 chr2:26402098 FAM59B -0.78 -9.4 -0.5 2.75e-18 Gut microbiome composition (summer); CESC cis rs1832871 0.505 rs11757895 chr6:158812456 G/T cg07165851 chr6:158734300 TULP4 0.54 5.15 0.3 5.09e-7 Height; CESC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC trans rs2727020 0.556 rs2866365 chr11:49390731 A/G cg03929089 chr4:120376271 NA -0.69 -7.7 -0.43 2.66e-13 Coronary artery disease; CESC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Depression; CESC cis rs12464559 0.649 rs10171724 chr2:152672482 T/A cg01189475 chr2:152685088 ARL5A 0.66 5.81 0.34 1.74e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg10645314 chr2:3704589 ALLC -0.62 -6.02 -0.35 5.68e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs9790314 0.967 rs336586 chr3:161081347 G/A cg03342759 chr3:160939853 NMD3 -0.49 -6.41 -0.37 6.54e-10 Morning vs. evening chronotype; CESC cis rs13392177 0.647 rs6718220 chr2:219066518 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.51 -6.32 -0.36 1.07e-9 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs2952156 0.684 rs11658786 chr17:37815899 G/A cg07936489 chr17:37558343 FBXL20 -0.58 -7.62 -0.42 4.56e-13 Asthma; CESC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg12463550 chr7:65579703 CRCP 0.56 7.08 0.4 1.33e-11 Aortic root size; CESC cis rs72781680 1.000 rs11125372 chr2:24257582 A/T cg20701182 chr2:24300061 SF3B14 -0.75 -7.38 -0.41 2.1e-12 Lymphocyte counts; CESC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg04025307 chr7:1156635 C7orf50 0.56 9.56 0.51 8.34e-19 Longevity;Endometriosis; CESC cis rs1797081 0.811 rs1797076 chr10:16853076 A/G cg23933602 chr10:16859644 RSU1 1.0 17.79 0.74 4.04e-47 Platelet distribution width; CESC cis rs11122272 0.735 rs2808604 chr1:231538916 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.47 -0.42 1.14e-12 Hemoglobin concentration; CESC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg18230493 chr5:56204884 C5orf35 -0.71 -8.43 -0.46 2.25e-15 Initial pursuit acceleration; CESC cis rs7208859 0.623 rs7503542 chr17:29073830 A/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs17739167 0.550 rs6493014 chr15:42225008 A/G cg20935245 chr15:42234343 EHD4 -0.36 -5.11 -0.3 6.3e-7 Monocyte count; CESC cis rs9435341 0.965 rs55924375 chr1:107566690 C/A cg09367891 chr1:107599246 PRMT6 0.7 8.2 0.45 1.04e-14 Facial morphology (factor 21, depth of nasal alae); CESC cis rs75804782 0.641 rs55844289 chr2:239323207 C/T cg18131467 chr2:239335373 ASB1 -0.69 -5.73 -0.33 2.75e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 11.48 0.58 4.99e-25 Platelet count; CESC cis rs1065852 0.526 rs9623490 chr22:42398266 G/C cg22189786 chr22:42395067 WBP2NL 0.43 5.37 0.31 1.72e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs7940866 0.817 rs961491 chr11:130866090 G/T cg12179176 chr11:130786555 SNX19 0.63 8.89 0.48 9.59e-17 Schizophrenia; CESC cis rs2073300 0.609 rs2281428 chr20:23400050 C/T cg16736954 chr20:23401023 NAPB 0.76 5.61 0.33 5.2100000000000003e-08 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs10129255 0.500 rs1024350 chr14:107141122 C/T cg23076370 chr14:107095027 NA -0.62 -9.39 -0.5 2.85e-18 Kawasaki disease; CESC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg12756686 chr19:29218302 NA 0.58 7.33 0.41 2.79e-12 Methadone dose in opioid dependence; CESC cis rs9287719 0.934 rs12692418 chr2:10745870 T/C cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC cis rs2204008 0.720 rs11181343 chr12:38323616 G/T cg26384229 chr12:38710491 ALG10B 0.7 10.35 0.54 2.72e-21 Bladder cancer; CESC cis rs10876993 0.890 rs115106209 chr12:58059331 G/A cg18357645 chr12:58087776 OS9 0.63 10.3 0.53 3.8e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs593982 1.000 rs470360 chr11:65500530 T/C cg08755490 chr11:65554678 OVOL1 1.31 20.14 0.78 2.41e-55 Atopic dermatitis; CESC cis rs5753037 0.543 rs140119 chr22:30138149 A/T cg01021169 chr22:30184971 ASCC2 -0.55 -7.87 -0.44 9.34e-14 Type 1 diabetes; CESC cis rs3750082 0.852 rs2392152 chr7:32900549 A/G cg08946731 chr7:32981826 RP9P -0.36 -5.17 -0.3 4.69e-7 Glomerular filtration rate (creatinine); CESC cis rs8078723 0.714 rs3859187 chr17:38150613 C/A cg17467752 chr17:38218738 THRA -0.56 -8.52 -0.46 1.22e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs11871801 0.517 rs665268 chr17:40722029 A/G cg16308533 chr17:40838983 CNTNAP1 0.4 5.26 0.31 3e-7 Crohn's disease; CESC cis rs1927790 0.697 rs7981931 chr13:96934176 C/T cg02571835 chr13:96230311 CLDN10 -0.39 -5.51 -0.32 8.55e-8 Body mass index; CESC cis rs11608355 0.515 rs61941592 chr12:109930497 G/A cg05360138 chr12:110035743 NA 0.81 8.63 0.47 5.62e-16 Neuroticism; CESC cis rs11690935 0.885 rs10202823 chr2:172780132 T/C cg13550731 chr2:172543902 DYNC1I2 -0.84 -12.32 -0.6 7.06e-28 Schizophrenia; CESC cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg14820908 chr5:178986412 RUFY1 0.46 7.12 0.4 1.03e-11 Lung cancer; CESC cis rs9549367 0.762 rs9549694 chr13:113870510 G/A cg18105134 chr13:113819100 PROZ -0.73 -9.72 -0.51 2.74e-19 Platelet distribution width; CESC cis rs9811920 0.893 rs9814549 chr3:99892190 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.38 -5.13 -0.3 5.59e-7 Axial length; CESC trans rs12599106 0.584 rs12929704 chr16:34898258 C/A cg15383120 chr6:291909 DUSP22 -0.66 -8.25 -0.45 7.55e-15 Menopause (age at onset); CESC cis rs7605827 0.930 rs1861768 chr2:15625186 C/A cg19274914 chr2:15703543 NA 0.36 6.41 0.37 6.6e-10 Educational attainment (years of education); CESC cis rs858239 0.601 rs987257 chr7:23147840 G/A cg23682824 chr7:23144976 KLHL7 0.54 7.44 0.42 1.41e-12 Cerebrospinal fluid biomarker levels; CESC cis rs2637266 1.000 rs12413656 chr10:78379666 A/C cg18941641 chr10:78392320 NA 0.43 8.17 0.45 1.28e-14 Pulmonary function; CESC cis rs9815354 0.812 rs73071344 chr3:41827062 C/T cg03022575 chr3:42003672 ULK4 0.69 6.08 0.35 4.18e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs4700695 0.719 rs27086 chr5:65453185 A/G cg21114390 chr5:65439923 SFRS12 -0.48 -5.9 -0.34 1.14e-8 Facial morphology (factor 19); CESC cis rs7799006 0.606 rs878534 chr7:2314652 G/A cg08027265 chr7:2291960 NA -0.58 -9.79 -0.52 1.56e-19 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 12.99 0.62 3.52e-30 Personality dimensions; CESC cis rs722599 0.628 rs12896360 chr14:75278181 A/C cg08847533 chr14:75593920 NEK9 0.47 5.85 0.34 1.46e-8 IgG glycosylation; CESC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg24881330 chr22:46731750 TRMU 0.79 6.93 0.39 3.24e-11 LDL cholesterol;Cholesterol, total; CESC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg23462726 chr11:62437636 C11orf83;C11orf48 0.41 5.53 0.32 7.82e-8 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC cis rs751728 0.664 rs943475 chr6:33749978 C/T cg25922239 chr6:33757077 LEMD2 -0.4 -5.68 -0.33 3.5e-8 Crohn's disease; CESC cis rs2777491 0.915 rs28583065 chr15:41608470 T/C cg20272979 chr15:41787780 ITPKA 0.36 5.16 0.3 4.84e-7 Ulcerative colitis; CESC cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg10645314 chr2:3704589 ALLC -0.46 -5.18 -0.3 4.35e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs9543976 0.623 rs8192756 chr13:76164938 C/T cg01531495 chr13:76123901 UCHL3 0.5 5.03 0.3 9.04e-7 Diabetic retinopathy; CESC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg06634786 chr22:41940651 POLR3H -0.63 -6.8 -0.39 6.78e-11 Vitiligo; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13649253 chr19:13198798 NFIX 0.47 6.78 0.38 7.68e-11 Gut microbiota (bacterial taxa); CESC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg09699651 chr6:150184138 LRP11 0.39 5.04 0.3 8.78e-7 Lung cancer; CESC cis rs5747327 0.775 rs5747308 chr22:18133500 A/C cg19898043 chr22:18121309 BCL2L13 -0.4 -5.09 -0.3 6.74e-7 Myeloid white cell count;Granulocyte count; CESC cis rs6690583 0.697 rs10873684 chr1:85522196 T/C cg22153463 chr1:85462885 MCOLN2 -0.66 -8.3 -0.45 5.4e-15 Serum sulfate level; CESC cis rs11785400 0.793 rs2976399 chr8:143746050 C/T cg24634471 chr8:143751801 JRK 0.44 5.57 0.32 6.23e-8 Schizophrenia; CESC cis rs72781680 0.898 rs72786276 chr2:24062566 G/A cg08917208 chr2:24149416 ATAD2B 1.13 10.31 0.54 3.47e-21 Lymphocyte counts; CESC cis rs72829446 0.530 rs7210231 chr17:7357864 C/A cg02795151 chr17:7402630 POLR2A 0.53 5.8 0.34 1.86e-8 Androgen levels; CESC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.03e-11 Tonsillectomy; CESC cis rs3540 0.597 rs4932346 chr15:91048991 T/C cg22089800 chr15:90895588 ZNF774 -0.6 -7.97 -0.44 4.73e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs12500824 0.564 rs62303271 chr4:77329036 C/T cg20311846 chr4:77356250 SHROOM3 0.39 7.5 0.42 9.73e-13 Coronary artery disease; CESC cis rs1003719 0.680 rs2835619 chr21:38505380 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.56 -0.47 9.46e-16 Eye color traits; CESC cis rs7086627 0.515 rs7077373 chr10:82211615 C/T cg00277334 chr10:82204260 NA -0.91 -16.25 -0.71 1.13e-41 Post bronchodilator FEV1; CESC cis rs317689 0.690 rs618470 chr12:69672060 A/G cg14784868 chr12:69753453 YEATS4 0.5 5.46 0.32 1.09e-7 Response to diuretic therapy; CESC trans rs7395662 0.591 rs4882233 chr11:48739653 A/G cg15704280 chr7:45808275 SEPT13 -0.54 -6.54 -0.37 3.07e-10 HDL cholesterol; CESC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg00149659 chr3:10157352 C3orf10 0.75 9.05 0.49 3.07e-17 Alzheimer's disease; CESC cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg26597838 chr10:835615 NA 0.67 6.29 0.36 1.32e-9 Eosinophil percentage of granulocytes; CESC cis rs12618769 0.520 rs11892744 chr2:99237792 C/T cg10123293 chr2:99228465 UNC50 0.42 5.27 0.31 2.85e-7 Bipolar disorder; CESC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg27170947 chr2:26402098 FAM59B 0.82 8.77 0.47 2.17e-16 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07908229 chr1:182353640 GLUL 0.49 6.12 0.35 3.44e-9 Ulcerative colitis; CESC cis rs1707322 0.721 rs11211178 chr1:46227566 G/T cg05343316 chr1:45956843 TESK2 0.5 6.16 0.35 2.65e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs854765 0.547 rs2955377 chr17:17932818 G/A cg04398451 chr17:18023971 MYO15A -0.71 -10.37 -0.54 2.34e-21 Total body bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03481159 chr7:5269161 WIPI2 -0.37 -6.03 -0.35 5.63e-9 Gambling; CESC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.15e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg18230493 chr5:56204884 C5orf35 0.71 8.67 0.47 4.54e-16 Initial pursuit acceleration; CESC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.56 0.37 2.89e-10 Prudent dietary pattern; CESC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg06074448 chr4:187884817 NA -0.37 -5.45 -0.32 1.16e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg15445000 chr17:37608096 MED1 -0.38 -6.16 -0.35 2.71e-9 Glomerular filtration rate (creatinine); CESC cis rs787274 1.000 rs787292 chr9:115508529 A/G cg13803584 chr9:115635662 SNX30 0.65 5.5 0.32 9.04e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7772486 0.686 rs9403741 chr6:146030548 G/A cg23711669 chr6:146136114 FBXO30 -0.89 -13.24 -0.63 4.85e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs3749237 0.615 rs11130202 chr3:49566715 C/T cg02487422 chr3:49467188 NICN1 0.55 8.13 0.45 1.68e-14 Resting heart rate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14266436 chr19:34302242 KCTD15 0.46 6.09 0.35 4.03e-9 Fibrinogen levels; CESC cis rs892961 0.932 rs11657961 chr17:75405407 C/T cg05865280 chr17:75406074 SEPT9 0.58 10.64 0.55 2.94e-22 Airflow obstruction; CESC cis rs1023500 0.506 rs6002625 chr22:42517689 A/G cg04733989 chr22:42467013 NAGA -0.8 -11.35 -0.57 1.33e-24 Schizophrenia; CESC cis rs9902453 0.934 rs7223645 chr17:28491029 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 7.88 0.44 8.52e-14 Coffee consumption (cups per day); CESC cis rs2066819 1.000 rs1274493 chr12:56682371 C/T cg26316697 chr12:56727976 PAN2 -0.69 -6.64 -0.38 1.74e-10 Psoriasis vulgaris; CESC cis rs7188697 0.921 rs12445577 chr16:58587164 T/C cg21335942 chr16:58549945 SETD6 -0.45 -5.23 -0.31 3.43e-7 QT interval; CESC cis rs6460942 0.514 rs118124486 chr7:12470381 T/G cg20607287 chr7:12443886 VWDE -0.53 -8.43 -0.46 2.23e-15 Coronary artery disease; CESC cis rs67311347 1.000 rs28434528 chr3:40484893 A/G cg01475735 chr3:40494733 NA -0.4 -5.05 -0.3 8.35e-7 Renal cell carcinoma; CESC cis rs1018836 0.608 rs2142146 chr8:91464808 T/C cg16814680 chr8:91681699 NA -0.51 -7.09 -0.4 1.2e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2243480 1.000 rs34702770 chr7:65344823 T/C cg13147721 chr7:65941812 NA -0.87 -8.7 -0.47 3.54e-16 Diabetic kidney disease; CESC cis rs8092503 1.000 rs1833282 chr18:52501012 A/G cg12377874 chr18:52495404 RAB27B 0.37 6.12 0.35 3.4e-9 Childhood body mass index; CESC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg11764359 chr7:65958608 NA -0.68 -8.81 -0.48 1.68e-16 Aortic root size; CESC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg26441486 chr22:50317300 CRELD2 0.41 5.09 0.3 6.92e-7 Schizophrenia; CESC cis rs79839061 0.610 rs62297062 chr4:869698 C/T cg07828340 chr4:882639 GAK 1.07 8.26 0.45 6.86e-15 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11192808 chr8:101170185 SPAG1 -0.44 -6.24 -0.36 1.73e-9 Fibrinogen levels; CESC trans rs863345 0.967 rs1342958 chr1:158468676 A/C cg11186933 chr8:109455379 TTC35 -0.48 -6.68 -0.38 1.37e-10 Pneumococcal bacteremia; CESC cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg21573476 chr21:45109991 RRP1B -0.42 -5.94 -0.34 9.12e-9 Mean corpuscular volume; CESC cis rs854765 0.583 rs950966 chr17:17783748 A/G cg09796270 chr17:17721594 SREBF1 -0.45 -6.33 -0.36 1.05e-9 Total body bone mineral density; CESC cis rs2120019 0.638 rs12050628 chr15:75333494 G/A cg17294928 chr15:75287854 SCAMP5 0.9 13.77 0.65 6.65e-33 Blood trace element (Zn levels); CESC cis rs472402 0.540 rs3776431 chr5:6618756 T/C cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.5 -6.67 -0.38 1.45e-10 Response to amphetamines; CESC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg08499158 chr17:42289980 UBTF -0.57 -7.34 -0.41 2.69e-12 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23654174 chr1:47779667 STIL -0.55 -6.28 -0.36 1.41e-9 Gut microbiome composition (summer); CESC cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs6570726 0.905 rs430248 chr6:145874104 A/G cg05347473 chr6:146136440 FBXO30 0.47 6.33 0.36 1.02e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs3820068 0.603 rs72647120 chr1:15956769 G/T cg13390004 chr1:15929781 NA 0.37 5.89 0.34 1.17e-8 Systolic blood pressure; CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg24642844 chr7:1081250 C7orf50 -0.4 -5.19 -0.3 4.23e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10927875 0.894 rs34957618 chr1:16320499 G/C cg21385522 chr1:16154831 NA -0.6 -7.57 -0.42 6.04e-13 Dilated cardiomyopathy; CESC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -8.99 -0.48 4.78e-17 Developmental language disorder (linguistic errors); CESC cis rs13256369 0.851 rs13266562 chr8:8564065 T/C cg00074818 chr8:8560427 CLDN23 0.38 5.46 0.32 1.1e-7 Obesity-related traits; CESC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg24675658 chr1:53192096 ZYG11B 0.62 8.66 0.47 4.77e-16 Monocyte count; CESC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.49 -0.32 9.5e-8 Developmental language disorder (linguistic errors); CESC cis rs2777491 0.874 rs1655556 chr15:41777935 A/C cg02330683 chr15:41787940 ITPKA 0.49 7.24 0.41 4.75e-12 Ulcerative colitis; CESC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg14393609 chr7:65229607 NA -0.41 -5.78 -0.33 2.1e-8 Aortic root size; CESC cis rs67478160 0.654 rs1997913 chr14:104213960 C/T cg08213375 chr14:104286397 PPP1R13B 0.54 10.8 0.55 9.16e-23 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25867650 chr15:75743273 SIN3A 0.55 6.54 0.37 3.23e-10 Gut microbiome composition (summer); CESC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg10862848 chr6:42927986 GNMT -0.26 -6.61 -0.38 2.09e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2439831 0.867 rs2255440 chr15:43830467 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.69 9.01 0.48 4.24e-17 Lung cancer in ever smokers; CESC cis rs2997447 0.761 rs61776575 chr1:26429844 G/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.31 0.31 2.31e-7 QRS complex (12-leadsum); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg19803043 chr1:167691022 MPZL1 -0.49 -6.02 -0.35 5.95e-9 Ulcerative colitis; CESC cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -9.35 -0.5 3.92e-18 Mean corpuscular volume; CESC cis rs4268898 0.735 rs34125395 chr2:24558242 C/T cg06627628 chr2:24431161 ITSN2 0.52 6.59 0.38 2.38e-10 Asthma; CESC cis rs12618769 0.652 rs7585747 chr2:99219071 T/C cg10123293 chr2:99228465 UNC50 0.4 5.19 0.3 4.2e-7 Bipolar disorder; CESC cis rs4566357 0.615 rs10184991 chr2:227916533 G/A cg11843606 chr2:227700838 RHBDD1 -0.51 -6.92 -0.39 3.33e-11 Coronary artery disease; CESC cis rs3008870 0.755 rs3929738 chr1:67397865 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.63 8.29 0.45 5.85e-15 Lymphocyte percentage of white cells; CESC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg11301795 chr4:187892539 NA -0.74 -12.21 -0.6 1.69e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs2730245 1.000 rs2730245 chr7:158724789 G/C cg24397884 chr7:158709396 WDR60 -0.88 -13.37 -0.63 1.71e-31 Height; CESC cis rs11252926 0.831 rs816570 chr10:680475 C/T cg08603382 chr10:743973 NA -0.59 -7.89 -0.44 7.94e-14 Psychosis in Alzheimer's disease; CESC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg00074818 chr8:8560427 CLDN23 -0.36 -5.19 -0.3 4.11e-7 Obesity-related traits; CESC cis rs2230307 0.505 rs482873 chr1:100589757 C/T cg24955406 chr1:100503596 HIAT1 -0.54 -5.41 -0.32 1.43e-7 Carotid intima media thickness; CESC cis rs3096299 0.781 rs2965819 chr16:89501030 G/T cg08392591 chr16:89556376 ANKRD11 -0.54 -7.23 -0.41 5.04e-12 Multiple myeloma (IgH translocation); CESC cis rs6500395 1.000 rs7198773 chr16:48606091 T/C cg04672837 chr16:48644449 N4BP1 0.51 6.38 0.36 7.94e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2463822 0.925 rs17157227 chr11:62169772 A/G cg06239285 chr11:62104954 ASRGL1 0.81 7.22 0.41 5.56e-12 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs9542155 0.532 rs2472285 chr13:70580104 C/A cg11781847 chr8:67837483 SNHG6 0.58 6.02 0.35 5.85e-9 Tonsillectomy; CESC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg06484146 chr7:12443880 VWDE -0.75 -8.85 -0.48 1.23e-16 Coronary artery disease; CESC cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg20701182 chr2:24300061 SF3B14 -0.93 -10.44 -0.54 1.31e-21 Lymphocyte counts; CESC cis rs7580658 0.637 rs4560059 chr2:127972228 T/C cg10021288 chr2:128175891 PROC -0.37 -5.69 -0.33 3.31e-8 Protein C levels; CESC cis rs6445967 0.569 rs17636819 chr3:58283722 C/T cg23715586 chr3:58305044 RPP14 0.46 7.37 0.41 2.12e-12 Platelet count; CESC cis rs2594989 1.000 rs2594978 chr3:11383347 C/A cg00170343 chr3:11313890 ATG7 0.56 5.17 0.3 4.71e-7 Circulating chemerin levels; CESC cis rs16854884 0.657 rs62268458 chr3:143736219 T/C cg06585982 chr3:143692056 C3orf58 0.49 6.14 0.35 2.96e-9 Economic and political preferences (feminism/equality); CESC cis rs763014 0.931 rs56048717 chr16:634867 A/G cg00908189 chr16:619842 PIGQ 0.64 9.0 0.48 4.57e-17 Height; CESC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg05754148 chr16:3507555 NAT15 -0.64 -6.12 -0.35 3.34e-9 Tuberculosis; CESC cis rs6580649 0.941 rs78649179 chr12:48508196 T/A cg05342945 chr12:48394962 COL2A1 0.55 6.3 0.36 1.25e-9 Lung cancer; CESC cis rs1008375 0.931 rs6449326 chr4:17699790 G/T cg16339924 chr4:17578868 LAP3 0.59 7.36 0.41 2.29e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg17971929 chr21:40555470 PSMG1 1.03 16.03 0.7 6.94e-41 Cognitive function; CESC cis rs7772486 0.686 rs9390357 chr6:146129347 A/G cg23711669 chr6:146136114 FBXO30 0.86 12.94 0.62 5.31e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs9457247 0.534 rs2757053 chr6:167380338 A/C cg25258033 chr6:167368657 RNASET2 -0.4 -5.74 -0.33 2.56e-8 Crohn's disease; CESC cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg24110177 chr3:50126178 RBM5 -0.54 -7.23 -0.41 5.19e-12 Intelligence (multi-trait analysis); CESC cis rs9300255 0.602 rs1616181 chr12:123619856 T/A cg19016782 chr12:123741754 C12orf65 -0.38 -5.15 -0.3 5.08e-7 Neutrophil percentage of white cells; CESC cis rs2361710 0.611 rs12451471 chr17:78102517 C/T cg24585782 chr17:78113791 EIF4A3 -0.51 -6.93 -0.39 3.13e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CESC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg05863683 chr7:1912471 MAD1L1 0.44 6.62 0.38 2.01e-10 Bipolar disorder and schizophrenia; CESC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg18099408 chr3:52552593 STAB1 -0.3 -5.09 -0.3 6.8e-7 Bipolar disorder; CESC cis rs1348850 0.914 rs3902850 chr2:178315899 G/A cg22681709 chr2:178499509 PDE11A -0.41 -5.95 -0.34 8.53e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs897984 0.762 rs12930545 chr16:30938811 A/G cg02466173 chr16:30829666 NA 0.49 8.33 0.46 4.26e-15 Dementia with Lewy bodies; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24179850 chr19:56154938 ZNF581 0.55 6.65 0.38 1.68e-10 Gut microbiome composition (summer); CESC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg23758822 chr17:41437982 NA 1.02 15.6 0.69 2.35e-39 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04811502 chr14:21979673 METTL3 -0.45 -6.4 -0.37 7.04e-10 Gut microbiota (bacterial taxa); CESC cis rs6963495 0.818 rs55825845 chr7:105166713 A/G cg19920283 chr7:105172520 RINT1 0.7 6.68 0.38 1.39e-10 Bipolar disorder (body mass index interaction); CESC cis rs8005677 1.000 rs4982710 chr14:23398902 C/T cg01529538 chr14:23388837 RBM23 0.5 6.79 0.38 7.31e-11 Cognitive ability (multi-trait analysis); CESC cis rs7191439 0.674 rs4782430 chr16:88792047 A/G cg02389323 chr16:88786976 FAM38A 0.91 8.18 0.45 1.19e-14 Plateletcrit; CESC cis rs561341 0.556 rs542244 chr17:30307242 T/C cg23018236 chr17:30244563 NA -0.52 -5.11 -0.3 6.28e-7 Hip circumference adjusted for BMI; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg09592463 chr17:40995321 PSME3;AOC2 0.44 6.09 0.35 4.03e-9 Thyroid stimulating hormone; CESC cis rs9916302 0.904 rs11078898 chr17:37536480 A/G cg07936489 chr17:37558343 FBXL20 0.82 11.86 0.59 2.58e-26 Glomerular filtration rate (creatinine); CESC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg04414720 chr1:150670196 GOLPH3L -0.48 -6.07 -0.35 4.32e-9 Blood protein levels; CESC cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg11764359 chr7:65958608 NA 0.97 15.56 0.69 3.06e-39 Aortic root size; CESC cis rs4853012 0.793 rs6723185 chr2:74344884 T/A cg19729930 chr2:74357872 NA 0.88 13.24 0.63 4.76e-31 Gestational age at birth (maternal effect); CESC cis rs947211 0.898 rs1772153 chr1:205745782 C/T cg26354017 chr1:205819088 PM20D1 -0.41 -5.11 -0.3 6.14e-7 Parkinson's disease; CESC trans rs11098499 0.775 rs10021601 chr4:120282563 G/A cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC trans rs3741489 1.000 rs11147098 chr12:133406374 G/A cg24132527 chr5:140019269 TMCO6 1.1 7.33 0.41 2.74e-12 Cognitive function; CESC cis rs3740713 1.000 rs76586692 chr11:18453726 A/G cg23797887 chr11:18477753 LDHAL6A -0.53 -5.27 -0.31 2.89e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg25036284 chr2:26402008 FAM59B -0.84 -9.59 -0.51 7.03e-19 Gut microbiome composition (summer); CESC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg09877947 chr5:131593287 PDLIM4 0.47 6.12 0.35 3.31e-9 Breast cancer; CESC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -6.73 -0.38 1.02e-10 Bipolar disorder; CESC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg04369109 chr6:150039330 LATS1 -0.4 -5.51 -0.32 8.45e-8 Lung cancer; CESC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg11890956 chr21:40555474 PSMG1 1.17 22.29 0.81 1.05e-62 Cognitive function; CESC cis rs7107174 1.000 rs7107174 chr11:77997936 C/T cg02023728 chr11:77925099 USP35 0.51 6.79 0.38 7.31e-11 Testicular germ cell tumor; CESC cis rs6987853 0.787 rs2923436 chr8:42425298 G/A cg09913449 chr8:42400586 C8orf40 0.45 7.62 0.42 4.61e-13 Mean corpuscular hemoglobin concentration; CESC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg12963246 chr6:28129442 ZNF389 0.59 7.68 0.43 3e-13 Depression; CESC cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg10523679 chr1:76189770 ACADM -0.61 -6.16 -0.35 2.75e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs8060686 0.641 rs57408712 chr16:68242573 G/C cg26727032 chr16:67993705 SLC12A4 -0.53 -5.93 -0.34 9.49e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.77 0.33 2.25e-8 Menopause (age at onset); CESC cis rs2070997 0.534 rs6597640 chr9:133669338 G/T cg11464064 chr9:133710261 ABL1 0.55 6.46 0.37 4.91e-10 Response to amphetamines; CESC cis rs4974559 0.790 rs28712208 chr4:1316695 A/T cg02980000 chr4:1222292 CTBP1 0.67 7.42 0.41 1.55e-12 Systolic blood pressure; CESC cis rs9300255 0.510 rs1727322 chr12:123699520 A/G cg00376283 chr12:123451042 ABCB9 0.61 6.34 0.36 9.86e-10 Neutrophil percentage of white cells; CESC cis rs7312774 0.748 rs10492211 chr12:107298213 T/C cg16260113 chr12:107380972 MTERFD3 0.63 5.97 0.34 7.77e-9 Severe influenza A (H1N1) infection; CESC cis rs1401999 0.934 rs1132776 chr3:183696402 A/G cg01324343 chr3:183735012 ABCC5 0.62 13.06 0.63 2.04e-30 Anterior chamber depth; CESC cis rs752010 0.806 rs11210500 chr1:42089737 A/G cg12614395 chr1:42085415 HIVEP3 0.31 5.35 0.31 1.93e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs13256369 0.755 rs11776987 chr8:8559401 C/G cg17143192 chr8:8559678 CLDN23 0.77 8.6 0.47 7.18e-16 Obesity-related traits; CESC cis rs61931739 0.500 rs7296061 chr12:34435009 A/G cg19457237 chr12:34500585 NA 0.38 5.35 0.31 1.91e-7 Morning vs. evening chronotype; CESC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.48 -6.18 -0.35 2.39e-9 Total body bone mineral density; CESC cis rs7267979 1.000 rs2184000 chr20:25395878 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -18.03 -0.74 5.81e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs6456156 0.792 rs10946214 chr6:167516122 G/A cg07741184 chr6:167504864 NA 0.35 6.28 0.36 1.34e-9 Primary biliary cholangitis; CESC cis rs2243480 1.000 rs6958289 chr7:65657111 T/G cg13147721 chr7:65941812 NA 0.97 9.16 0.49 1.47e-17 Diabetic kidney disease; CESC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg27266027 chr21:40555129 PSMG1 0.45 5.49 0.32 9.25e-8 Cognitive function; CESC cis rs3105169 0.696 rs1492077 chr8:100350841 A/G cg05586662 chr8:100024465 VPS13B 0.39 5.09 0.3 6.9e-7 Smoking initiation; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg12782834 chr3:196439273 PIGX;C3orf34 -0.44 -6.15 -0.35 2.83e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.41e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -20.77 -0.79 1.6e-57 Height; CESC cis rs1878931 0.507 rs67218524 chr16:3403057 G/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.74 -9.12 -0.49 1.93e-17 Body mass index (adult); CESC cis rs12950390 0.820 rs58391889 chr17:45865959 A/G cg00777063 chr17:45855553 NA -0.39 -5.77 -0.33 2.24e-8 IgG glycosylation; CESC cis rs7208859 0.673 rs3764420 chr17:29164154 A/G cg19761014 chr17:28927070 LRRC37B2 0.72 5.68 0.33 3.48e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4423214 1.000 rs2276362 chr11:71174452 A/G cg05163923 chr11:71159392 DHCR7 0.84 11.4 0.57 9.55e-25 Vitamin D levels; CESC cis rs7246865 0.859 rs1379281 chr19:17189786 A/G cg19418318 chr19:17219073 MYO9B -0.32 -5.04 -0.3 8.83e-7 Reticulocyte fraction of red cells; CESC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg22920501 chr2:26401640 FAM59B -0.85 -10.05 -0.53 2.5e-20 Gut microbiome composition (summer); CESC cis rs7914558 0.933 rs1538204 chr10:104733893 T/A cg08650961 chr10:104748594 CNNM2 0.31 5.05 0.3 8.15e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04733624 chr10:75936339 ADK 0.61 7.29 0.41 3.61e-12 Gut microbiome composition (summer); CESC trans rs7839040 0.698 rs12543816 chr8:82932223 C/T cg14472086 chr9:107730925 NA -0.48 -6.45 -0.37 5.4e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs4950928 0.712 rs7518666 chr1:203163590 C/T cg14085262 chr1:203155938 CHI3L1 -0.51 -5.57 -0.32 6.25e-8 YKL-40 levels; CESC cis rs7937682 0.824 rs510866 chr11:111484113 A/C cg09085632 chr11:111637200 PPP2R1B -0.95 -14.7 -0.67 3.4e-36 Primary sclerosing cholangitis; CESC cis rs7615952 0.604 rs9837847 chr3:125623919 G/A cg05084668 chr3:125655381 ALG1L -0.78 -8.05 -0.44 2.83e-14 Blood pressure (smoking interaction); CESC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.13 0.3 5.72e-7 Menopause (age at onset); CESC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg00166722 chr3:10149974 C3orf24 0.48 5.92 0.34 9.76e-9 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00357593 chr19:14530417 DDX39 0.6 7.15 0.4 8.7e-12 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg22143856 chr6:28129313 ZNF389 0.52 6.75 0.38 9.54e-11 Depression; CESC cis rs6834538 0.597 rs2029211 chr4:113488134 A/G cg05166686 chr4:113558556 LARP7;C4orf21 0.44 5.43 0.32 1.28e-7 Free thyroxine concentration; CESC cis rs1215050 0.791 rs1585088 chr4:98675071 C/A cg05340658 chr4:99064831 C4orf37 -0.47 -6.04 -0.35 5.08e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg25811766 chr13:21894605 NA 0.76 10.97 0.56 2.54e-23 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs1493916 1.000 rs11081827 chr18:31390228 C/A cg27147174 chr7:100797783 AP1S1 -0.5 -6.66 -0.38 1.53e-10 Life satisfaction; CESC cis rs3733585 0.631 rs4697707 chr4:10119787 G/T cg11266682 chr4:10021025 SLC2A9 -0.55 -10.3 -0.53 3.87e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs73058052 1.000 rs73058052 chr19:50099422 C/T cg09250473 chr19:50168907 IRF3;BCL2L12 0.62 5.33 0.31 2.07e-7 Fibrinogen levels; CESC cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg06219351 chr7:158114137 PTPRN2 -0.49 -7.45 -0.42 1.29e-12 Calcium levels; CESC cis rs7336332 0.598 rs1885988 chr13:28010262 C/T cg01674679 chr13:27998804 GTF3A 0.59 5.56 0.32 6.52e-8 Weight; CESC cis rs1190552 0.894 rs4906203 chr14:102928991 C/T cg18135206 chr14:102964638 TECPR2 0.4 5.04 0.3 8.49e-7 Blood protein levels; CESC cis rs3752962 0.569 rs3803806 chr17:1940713 T/C cg24156229 chr17:1948635 NA -0.63 -9.57 -0.51 7.67e-19 Itch intensity from mosquito bite; CESC cis rs6696846 0.765 rs72757524 chr1:205086473 C/T cg00857998 chr1:205179979 DSTYK 0.57 7.44 0.42 1.4e-12 Red blood cell count; CESC cis rs2120019 1.000 rs35577967 chr15:75354621 G/A cg17294928 chr15:75287854 SCAMP5 -0.65 -6.96 -0.39 2.66e-11 Blood trace element (Zn levels); CESC cis rs9527 0.590 rs1926029 chr10:104855670 C/T cg04362960 chr10:104952993 NT5C2 0.42 5.09 0.3 6.86e-7 Arsenic metabolism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17746819 chr1:100715586 DBT 0.48 6.06 0.35 4.73e-9 Ulcerative colitis; CESC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg18765753 chr7:1198926 ZFAND2A -0.41 -5.15 -0.3 5.19e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9837602 0.688 rs793488 chr3:99495567 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -5.44 -0.32 1.19e-7 Breast cancer; CESC cis rs8067545 0.611 rs2042046 chr17:20018841 A/G cg13482628 chr17:19912719 NA 0.41 5.45 0.32 1.13e-7 Schizophrenia; CESC cis rs7772486 0.875 rs6909827 chr6:146365738 A/G cg23711669 chr6:146136114 FBXO30 0.76 11.14 0.56 6.6e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs10463316 0.894 rs10042030 chr5:150768028 T/C cg03212797 chr5:150827313 SLC36A1 -0.47 -6.15 -0.35 2.86e-9 Metabolite levels (Pyroglutamine); CESC cis rs939574 0.720 rs6714820 chr2:220071803 C/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.54 -5.26 -0.31 3.03e-7 Platelet distribution width; CESC cis rs7949030 0.653 rs2849030 chr11:62366986 G/A cg11742103 chr11:62369870 EML3;MTA2 -0.61 -9.29 -0.5 6.02e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6499129 0.764 rs7186310 chr16:67305513 A/C cg26727032 chr16:67993705 SLC12A4 -0.51 -5.64 -0.33 4.36e-8 Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25788012 chr8:145133899 EXOSC4 0.55 6.3 0.36 1.26e-9 Gut microbiome composition (summer); CESC cis rs6582630 0.519 rs8189461 chr12:38374870 G/T cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.62e-9 Drug-induced liver injury (flucloxacillin); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg08538778 chr1:115212897 DENND2C 0.48 6.03 0.35 5.5e-9 Psoriatic arthritis; CESC cis rs7727544 0.661 rs273900 chr5:131694606 G/A cg07395648 chr5:131743802 NA -0.4 -5.17 -0.3 4.56e-7 Blood metabolite levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04315863 chr15:34330588 AVEN;CHRM5 0.47 6.34 0.36 9.86e-10 Systemic lupus erythematosus; CESC cis rs7267979 1.000 rs6050565 chr20:25347563 A/C cg08601574 chr20:25228251 PYGB -0.37 -5.55 -0.32 6.81e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7914558 1.000 rs11191541 chr10:104824199 A/G cg15744005 chr10:104629667 AS3MT -0.34 -5.49 -0.32 9.49e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6502050 0.761 rs13949 chr17:80059596 T/C cg23985595 chr17:80112537 CCDC57 0.38 5.85 0.34 1.47e-8 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.14.1168716F chr14:77543787 NA -0.59 -7.4 -0.41 1.85e-12 Gut microbiome composition (summer); CESC cis rs258892 0.895 rs34656 chr5:72148117 C/T cg21869765 chr5:72125136 TNPO1 0.44 5.55 0.32 6.92e-8 Small cell lung carcinoma; CESC cis rs59918340 0.764 rs4961338 chr8:142230192 C/T cg23750338 chr8:142222470 SLC45A4 -0.62 -9.61 -0.51 6.07e-19 Immature fraction of reticulocytes; CESC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg27121462 chr16:89883253 FANCA 0.77 11.14 0.56 6.67e-24 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16778319 chr15:40733174 BAHD1 0.6 6.94 0.39 2.94e-11 Gut microbiome composition (summer); CESC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg14664628 chr15:75095509 CSK -0.52 -6.85 -0.39 5.25e-11 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06296553 chr12:124810874 NCOR2 0.46 6.64 0.38 1.8e-10 Fibrinogen levels; CESC trans rs9354308 0.867 rs2802051 chr6:66536403 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 6.67 0.38 1.5e-10 Metabolite levels; CESC cis rs7223966 1.000 rs2854219 chr17:61942682 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 5.78 0.33 2.13e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2191566 0.664 rs4803669 chr19:44539962 C/A cg20607764 chr19:44506953 ZNF230 -0.43 -5.52 -0.32 8.25e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg07701084 chr6:150067640 NUP43 0.46 6.52 0.37 3.54e-10 Lung cancer; CESC cis rs117623576 0.941 rs211422 chr10:32398589 A/G cg03047570 chr10:32398778 NA 0.78 8.22 0.45 9.22e-15 Anti-saccade response; CESC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg24675658 chr1:53192096 ZYG11B 0.56 7.64 0.42 4.03e-13 Monocyte count; CESC cis rs2522056 1.000 rs11242113 chr5:131777234 G/A cg24060327 chr5:131705240 SLC22A5 0.68 8.14 0.45 1.56e-14 Lymphocyte counts;Fibrinogen; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12389545 chr11:72353604 PDE2A 0.5 6.07 0.35 4.49e-9 Gut microbiome composition (summer); CESC cis rs12586317 0.513 rs11156871 chr14:35481196 G/A cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg18512352 chr11:47633146 NA 0.54 7.97 0.44 4.64e-14 Subjective well-being; CESC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg13206674 chr6:150067644 NUP43 0.43 6.27 0.36 1.44e-9 Lung cancer; CESC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg17372223 chr3:52568218 NT5DC2 0.44 6.63 0.38 1.86e-10 Bipolar disorder; CESC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg00166722 chr3:10149974 C3orf24 0.48 5.95 0.34 8.39e-9 Alzheimer's disease; CESC cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg02487422 chr3:49467188 NICN1 0.5 6.35 0.36 9.14e-10 Parkinson's disease; CESC cis rs990171 0.506 rs9284725 chr2:102744854 C/A cg22835712 chr2:102737379 NA 0.43 6.01 0.35 6.14e-9 Lymphocyte counts; CESC cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.92 8.08 0.44 2.36e-14 Initial pursuit acceleration; CESC cis rs3768617 0.510 rs20563 chr1:183085755 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.88 -14.2 -0.66 2.08e-34 Fuchs's corneal dystrophy; CESC cis rs796364 1.000 rs281759 chr2:200787719 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.87 8.3 0.45 5.2e-15 Schizophrenia; CESC cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg25019033 chr10:957182 NA -0.58 -6.32 -0.36 1.12e-9 Eosinophil percentage of granulocytes; CESC cis rs6598163 0.520 rs12813376 chr12:132302324 C/T cg22244940 chr12:132335942 MMP17 0.4 5.41 0.32 1.39e-7 Migraine; CESC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.68 0.38 1.39e-10 Bipolar disorder; CESC cis rs3008870 0.755 rs4655660 chr1:67402953 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.63 8.34 0.46 4.16e-15 Lymphocyte percentage of white cells; CESC cis rs9611565 0.765 rs202659 chr22:41811620 T/C cg03806693 chr22:41940476 POLR3H 1.04 12.37 0.61 4.76e-28 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23666278 chr2:171785822 GORASP2 -0.5 -6.78 -0.38 8e-11 Fibrinogen levels; CESC cis rs6893300 0.524 rs62404348 chr5:179146026 G/A cg14593053 chr5:179126677 CANX 0.6 8.88 0.48 1.05e-16 Resting heart rate; CESC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg00129232 chr17:37814104 STARD3 0.49 6.16 0.35 2.69e-9 Glomerular filtration rate (creatinine); CESC trans rs11165623 0.792 rs9437607 chr1:96977788 G/A cg10631902 chr5:14652156 NA -0.47 -6.91 -0.39 3.59e-11 Hip circumference;Waist circumference; CESC cis rs6741892 0.536 rs6761563 chr2:38891406 A/T cg23643435 chr2:38893251 GALM -0.66 -9.13 -0.49 1.85e-17 5-HTT brain serotonin transporter levels; CESC cis rs7216064 1.000 rs62084240 chr17:65859233 C/A cg12091567 chr17:66097778 LOC651250 -0.85 -8.6 -0.47 7.26e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10463316 0.894 rs6864722 chr5:150752942 G/A cg03212797 chr5:150827313 SLC36A1 -0.42 -5.41 -0.32 1.41e-7 Metabolite levels (Pyroglutamine); CESC cis rs7312933 0.670 rs10880258 chr12:42547531 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.47 6.16 0.35 2.68e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs9522267 0.535 rs4773393 chr13:112229755 A/G cg10483660 chr13:112241077 NA -0.33 -5.82 -0.34 1.67e-8 Hepatitis; CESC cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg00677455 chr12:58241039 CTDSP2 -0.52 -6.66 -0.38 1.62e-10 Multiple sclerosis; CESC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg05564831 chr3:52568323 NT5DC2 0.46 6.96 0.39 2.61e-11 Bipolar disorder; CESC cis rs9411298 0.630 rs9411299 chr9:139938793 C/G cg14024893 chr9:139943146 ENTPD2 -0.45 -6.27 -0.36 1.47e-9 Monocyte percentage of white cells; CESC cis rs3091242 0.933 rs35403885 chr1:25784551 G/A cg27572855 chr1:25598939 RHD -0.43 -7.19 -0.4 6.65e-12 Erythrocyte sedimentation rate; CESC cis rs17095355 1.000 rs7080576 chr10:111710817 C/T cg00817464 chr10:111662876 XPNPEP1 0.43 5.19 0.3 4.26e-7 Biliary atresia; CESC cis rs4065321 0.522 rs34648856 chr17:38149411 G/A cg17467752 chr17:38218738 THRA -0.45 -5.91 -0.34 1.04e-8 White blood cell count (basophil);White blood cell count; CESC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg03806693 chr22:41940476 POLR3H -1.25 -17.05 -0.72 1.64e-44 Vitiligo; CESC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg12963246 chr6:28129442 ZNF389 0.4 5.24 0.31 3.24e-7 Depression; CESC cis rs10028773 0.546 rs13117947 chr4:120257060 A/G cg09307838 chr4:120376055 NA 0.53 7.19 0.4 6.64e-12 Educational attainment; CESC cis rs66561647 0.719 rs7812386 chr8:128937609 C/A cg05480350 chr8:128972681 MIR1205;PVT1 0.42 5.56 0.32 6.7e-8 Hemoglobin concentration; CESC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg17724175 chr1:150552817 MCL1 0.43 6.87 0.39 4.68e-11 Tonsillectomy; CESC cis rs10899021 0.790 rs10899022 chr11:74339386 C/T cg25880958 chr11:74394337 NA -0.74 -7.86 -0.43 9.76e-14 Response to metformin (IC50); CESC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.2e-17 Prudent dietary pattern; CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg15147215 chr3:52552868 STAB1 -0.37 -6.67 -0.38 1.52e-10 Electroencephalogram traits; CESC cis rs2735413 0.918 rs11643649 chr16:78081199 T/C cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs4588572 0.643 rs1864173 chr5:77691158 C/T cg11547950 chr5:77652471 NA 0.45 5.71 0.33 3.06e-8 Triglycerides; CESC cis rs7267979 0.844 rs6132824 chr20:25238173 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.72 11.88 0.59 2.27e-26 Liver enzyme levels (alkaline phosphatase); CESC cis rs6460942 0.915 rs62448600 chr7:12454944 T/G cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC trans rs459571 0.635 rs379471 chr9:136890649 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.57 -7.3 -0.41 3.37e-12 Platelet distribution width; CESC cis rs8078723 0.714 rs8070444 chr17:38151960 A/G cg17467752 chr17:38218738 THRA -0.56 -8.39 -0.46 3.01e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs1153858 1.000 rs16942000 chr15:45633003 C/T cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs9457247 1.000 rs239935 chr6:167411788 G/A cg25258033 chr6:167368657 RNASET2 0.4 6.08 0.35 4.07e-9 Crohn's disease; CESC cis rs12142240 0.738 rs67545510 chr1:46806242 G/T cg00530320 chr1:46809349 NSUN4 0.59 7.85 0.43 1.02e-13 Menopause (age at onset); CESC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg11644478 chr21:40555479 PSMG1 -0.55 -7.42 -0.41 1.55e-12 Menarche (age at onset); CESC cis rs56104184 0.615 rs73061693 chr19:49399941 C/A cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs4144743 1.000 rs34492688 chr17:45321622 C/A cg18085866 chr17:45331354 ITGB3 -0.64 -7.03 -0.4 1.78e-11 Body mass index; CESC cis rs6502050 0.835 rs11077971 chr17:80090629 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.59 -0.38 2.38e-10 Life satisfaction; CESC trans rs507506 0.771 rs929229 chr17:7105399 C/T cg15655154 chr3:113604241 GRAMD1C 0.64 8.65 0.47 4.97e-16 Adiponectin levels; CESC cis rs1800795 0.599 rs1546762 chr7:22757503 C/T cg05472934 chr7:22766657 IL6 0.52 6.9 0.39 3.81e-11 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CESC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg11764359 chr7:65958608 NA 0.67 8.6 0.47 7.12e-16 Aortic root size; CESC cis rs1707322 0.721 rs11211151 chr1:46112752 T/C cg03146154 chr1:46216737 IPP 0.82 11.49 0.58 4.71e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11599315 0.757 rs11250392 chr10:1342543 T/C cg01270228 chr10:1369114 ADARB2 0.35 5.11 0.3 6.11e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6500395 1.000 rs12597928 chr16:48714366 G/A cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2777491 0.957 rs3743038 chr15:41694743 C/T cg18705301 chr15:41695430 NDUFAF1 -0.66 -10.25 -0.53 5.55e-21 Ulcerative colitis; CESC trans rs13035304 0.686 rs13005792 chr2:130508303 T/G cg18827756 chr15:42130735 JMJD7-PLA2G4B;PLA2G4B -0.45 -7.15 -0.4 8.33e-12 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs831571 1.000 rs831571 chr3:64048297 A/G cg16258503 chr3:63850278 ATXN7;THOC7 0.51 5.16 0.3 4.77e-7 Type 2 diabetes; CESC cis rs4481887 0.927 rs4244181 chr1:248471118 A/G cg00666640 chr1:248458726 OR2T12 0.4 6.57 0.37 2.7e-10 Common traits (Other); CESC cis rs6460942 0.597 rs4721108 chr7:12535247 C/T cg06484146 chr7:12443880 VWDE -0.73 -7.77 -0.43 1.68e-13 Coronary artery disease; CESC cis rs4727027 0.933 rs6955564 chr7:148866173 A/G cg23583168 chr7:148888333 NA -0.69 -10.42 -0.54 1.59e-21 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg23048001 chr7:2026167 MAD1L1 0.43 5.72 0.33 2.86e-8 Schizophrenia; CESC trans rs1814175 0.645 rs866427 chr11:49923853 G/A cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06349981 chr2:10443745 HPCAL1 0.63 6.94 0.39 3.01e-11 Gut microbiome composition (summer); CESC cis rs847577 0.506 rs7808528 chr7:97721425 G/T cg21770322 chr7:97807741 LMTK2 0.85 15.08 0.68 1.63e-37 Breast cancer; CESC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg18490616 chr2:88469792 THNSL2 0.56 5.2 0.3 4.05e-7 Plasma clusterin levels; CESC cis rs7264396 0.635 rs6060692 chr20:34517925 A/T cg04508476 chr20:34239394 CPNE1;RBM12 0.76 10.58 0.54 4.88e-22 Total cholesterol levels; CESC cis rs2299587 0.554 rs2073562 chr8:17742929 A/G cg08627089 chr8:17753878 FGL1 -0.4 -5.82 -0.34 1.67e-8 Economic and political preferences; CESC cis rs7186908 0.711 rs9923344 chr16:72190653 T/C cg16558253 chr16:72132732 DHX38 -0.44 -5.38 -0.31 1.6e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs6062302 0.545 rs2297430 chr20:62229244 T/C cg06363034 chr20:62225388 GMEB2 -0.53 -6.81 -0.39 6.5e-11 Glioblastoma; CESC cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg05025164 chr4:1340916 KIAA1530 0.47 6.26 0.36 1.53e-9 Longevity; CESC cis rs8060686 0.668 rs8048034 chr16:68210604 A/G cg26727032 chr16:67993705 SLC12A4 -0.58 -8.22 -0.45 9.17e-15 HDL cholesterol;Metabolic syndrome; CESC cis rs17293817 0.618 rs35155296 chr10:1433333 C/T cg04271617 chr10:1416546 ADARB2 0.33 5.05 0.3 8.19e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs6912958 0.781 rs4707379 chr6:88310623 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.07 -0.3 7.4e-7 Monocyte percentage of white cells; CESC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg16325326 chr1:53192061 ZYG11B 0.9 15.28 0.68 3.2e-38 Monocyte count; CESC cis rs9911578 1.000 rs3744108 chr17:56585872 G/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -5.42 -0.32 1.37e-7 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14063914 chr6:158588963 GTF2H5;SERAC1 -0.39 -6.04 -0.35 5.21e-9 Gambling; CESC cis rs7089973 0.628 rs11196953 chr10:116607707 A/G cg03647239 chr10:116582469 FAM160B1 0.43 5.35 0.31 1.94e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7312933 0.524 rs11181465 chr12:42765098 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.37 0.36 8.11e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs2997447 0.846 rs61775431 chr1:26411275 T/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.14e-7 QRS complex (12-leadsum); CESC cis rs17253792 0.545 rs17745459 chr14:56008549 T/A cg01858014 chr14:56050164 KTN1 -0.87 -6.66 -0.38 1.56e-10 Putamen volume; CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg22907277 chr7:1156413 C7orf50 0.42 5.89 0.34 1.15e-8 Longevity;Endometriosis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04874326 chr6:2634942 C6orf195 0.48 6.61 0.38 2.09e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9811920 0.609 rs7638900 chr3:99670773 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.61 -9.74 -0.51 2.37e-19 Axial length; CESC trans rs1814175 0.645 rs7395438 chr11:49877379 G/T cg11707556 chr5:10655725 ANKRD33B -0.42 -6.16 -0.35 2.66e-9 Height; CESC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg07153921 chr17:41440717 NA -0.38 -5.18 -0.3 4.3e-7 Menopause (age at onset); CESC cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg08564027 chr20:61660810 NA -0.91 -14.9 -0.68 6.89e-37 Prostate cancer (SNP x SNP interaction); CESC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg02711726 chr17:80685570 FN3KRP -0.38 -5.07 -0.3 7.65e-7 Glycated hemoglobin levels; CESC cis rs155076 0.625 rs4769159 chr13:21881978 A/C cg25811766 chr13:21894605 NA 0.56 5.64 0.33 4.32e-8 White matter hyperintensity burden; CESC cis rs524281 0.682 rs4483592 chr11:65990439 C/T cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.38e-7 Electroencephalogram traits; CESC cis rs344364 0.511 rs1742464 chr16:1947335 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.54 6.13 0.35 3.23e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -5.32 -0.31 2.19e-7 Developmental language disorder (linguistic errors); CESC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg00310523 chr12:86230176 RASSF9 0.32 5.15 0.3 5.03e-7 Major depressive disorder; CESC cis rs17376456 0.825 rs28534784 chr5:93063332 C/A cg21475434 chr5:93447410 FAM172A 0.79 7.15 0.4 8.67e-12 Diabetic retinopathy; CESC cis rs472109 0.900 rs491205 chr11:9767559 G/A cg03108697 chr11:9732066 SWAP70 -0.35 -5.2 -0.3 3.96e-7 Coronary artery disease; CESC cis rs11792861 0.888 rs72607168 chr9:111832192 G/C cg05043794 chr9:111880884 C9orf5 -0.39 -6.39 -0.37 7.25e-10 Menarche (age at onset); CESC cis rs910316 1.000 rs876403 chr14:75602834 A/T cg16144293 chr14:75469539 EIF2B2 -0.39 -5.13 -0.3 5.63e-7 Height; CESC cis rs67478160 0.619 rs11160761 chr14:104254856 A/T cg01849466 chr14:104193079 ZFYVE21 -0.52 -7.31 -0.41 3.18e-12 Schizophrenia; CESC trans rs2727020 0.894 rs3862342 chr11:49357043 C/T cg03929089 chr4:120376271 NA -0.64 -7.4 -0.41 1.82e-12 Coronary artery disease; CESC cis rs10089 1.000 rs3805607 chr5:127477418 T/C cg19767477 chr5:127420684 SLC12A2 -0.39 -5.34 -0.31 1.96e-7 Ileal carcinoids; CESC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg20790798 chr5:1857306 NA -0.41 -5.49 -0.32 9.32e-8 Cardiovascular disease risk factors; CESC cis rs2708240 0.967 rs2247042 chr7:147580224 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.36 -5.99 -0.35 6.79e-9 QT interval (drug interaction); CESC cis rs12142240 0.698 rs66911505 chr1:46823298 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg16144293 chr14:75469539 EIF2B2 -0.4 -5.32 -0.31 2.22e-7 Height; CESC cis rs2760061 0.598 rs2796056 chr1:228122901 G/A cg01973587 chr1:228161476 NA 0.39 5.99 0.35 6.64e-9 Diastolic blood pressure; CESC cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg19717773 chr7:2847554 GNA12 -0.51 -6.46 -0.37 4.85e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18706879 chr14:74353254 ZNF410 0.58 6.47 0.37 4.77e-10 Gut microbiome composition (summer); CESC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg11644478 chr21:40555479 PSMG1 0.83 12.75 0.62 2.36e-29 Cognitive function; CESC cis rs8017423 0.845 rs114583024 chr14:90727628 T/C cg14092571 chr14:90743983 NA -0.55 -8.17 -0.45 1.24e-14 Mortality in heart failure; CESC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.01 11.06 0.56 1.27e-23 Platelet count; CESC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg25036284 chr2:26402008 FAM59B -0.84 -9.66 -0.51 4.19e-19 Gut microbiome composition (summer); CESC cis rs6674176 0.593 rs3791120 chr1:44431715 T/C cg12908607 chr1:44402522 ARTN -0.49 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs35955747 0.870 rs4820969 chr22:31773573 C/G cg25791279 chr22:32026902 PISD -0.47 -5.78 -0.33 2.08e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs6430585 0.583 rs4988145 chr2:136632300 A/C cg07169764 chr2:136633963 MCM6 1.31 20.14 0.78 2.38e-55 Corneal structure; CESC trans rs61931739 0.534 rs7302688 chr12:34235064 A/G cg26384229 chr12:38710491 ALG10B 0.65 9.25 0.49 7.67e-18 Morning vs. evening chronotype; CESC cis rs9911578 0.935 rs34523895 chr17:57034095 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.38 5.12 0.3 5.86e-7 Intelligence (multi-trait analysis); CESC cis rs4423214 0.592 rs10898223 chr11:71219264 G/A cg24826892 chr11:71159390 DHCR7 -0.51 -5.15 -0.3 5.04e-7 Vitamin D levels; CESC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg02487422 chr3:49467188 NICN1 0.42 5.74 0.33 2.59e-8 Parkinson's disease; CESC cis rs2932538 0.922 rs2273369 chr1:113072477 A/G cg22162597 chr1:113214053 CAPZA1 0.53 6.51 0.37 3.68e-10 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs6502050 0.835 rs9898697 chr17:80100498 A/G cg23985595 chr17:80112537 CCDC57 -0.42 -6.59 -0.38 2.39e-10 Life satisfaction; CESC cis rs742614 0.533 rs2747536 chr20:32404128 C/G cg06304546 chr20:32448765 NA -0.46 -5.78 -0.33 2.07e-8 Stearic acid (18:0) levels; CESC trans rs8073060 0.586 rs225257 chr17:33956625 G/A cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs477692 0.905 rs509041 chr10:131424948 A/G cg26102564 chr10:131424627 MGMT 0.36 5.39 0.31 1.52e-7 Response to temozolomide; CESC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 6.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11577318 0.853 rs4526602 chr1:26648034 C/T cg00852783 chr1:26633632 UBXN11 0.48 6.54 0.37 3.08e-10 Granulocyte percentage of myeloid white cells; CESC cis rs6964587 1.000 rs3753108 chr7:91629984 T/G cg17063962 chr7:91808500 NA 0.55 7.58 0.42 5.66e-13 Breast cancer; CESC cis rs72781680 0.898 rs17762609 chr2:24114729 G/T cg20701182 chr2:24300061 SF3B14 0.64 5.82 0.34 1.73e-8 Lymphocyte counts; CESC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 17.62 0.73 1.61e-46 Prudent dietary pattern; CESC cis rs3749237 0.595 rs10865955 chr3:49499829 G/A cg02487422 chr3:49467188 NICN1 0.56 8.15 0.45 1.48e-14 Resting heart rate; CESC cis rs9300255 0.550 rs10772997 chr12:123719880 C/A cg00376283 chr12:123451042 ABCB9 0.67 9.01 0.48 4.2e-17 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26428032 chr11:67387935 NA -0.52 -7.06 -0.4 1.49e-11 Gut microbiome composition (summer); CESC cis rs714031 0.934 rs5750870 chr22:40067640 G/A cg21377881 chr22:40064566 CACNA1I -0.33 -5.25 -0.31 3.07e-7 Schizophrenia; CESC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg05535760 chr7:792225 HEATR2 0.94 10.78 0.55 1.05e-22 Cerebrospinal P-tau181p levels; CESC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg23172400 chr8:95962367 TP53INP1 -0.45 -9.25 -0.49 8.02e-18 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12545570 chr21:27108482 ATP5J;GABPA 0.47 6.15 0.35 2.9e-9 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18916626 chr20:33265164 PIGU 0.57 6.53 0.37 3.42e-10 Gut microbiome composition (summer); CESC cis rs4555082 0.830 rs2816648 chr14:105708289 C/T cg27165867 chr14:105738592 BRF1 -0.53 -5.64 -0.33 4.44e-8 Mean platelet volume;Platelet distribution width; CESC cis rs11048434 0.736 rs2377673 chr12:9112551 A/G cg23795048 chr12:9217529 LOC144571 0.35 5.4 0.31 1.52e-7 Sjögren's syndrome; CESC cis rs3916 0.662 rs2138249 chr12:121124142 A/C cg26008908 chr12:120799332 MSI1 0.36 5.85 0.34 1.47e-8 Urinary metabolites (H-NMR features); CESC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg18230493 chr5:56204884 C5orf35 -0.42 -5.04 -0.3 8.72e-7 Type 2 diabetes; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg00521863 chr2:171783942 NA 0.43 6.11 0.35 3.61e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16681268 chr7:117067616 ASZ1 0.44 6.18 0.35 2.46e-9 Fibrinogen levels; CESC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg18876405 chr7:65276391 NA 0.54 7.06 0.4 1.5e-11 Aortic root size; CESC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg17143192 chr8:8559678 CLDN23 0.75 8.9 0.48 8.72e-17 Obesity-related traits; CESC cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg17211192 chr8:82754475 SNX16 0.49 6.32 0.36 1.09e-9 Diastolic blood pressure; CESC cis rs1387259 0.839 rs7486941 chr12:48578631 C/G cg24011408 chr12:48396354 COL2A1 -0.45 -6.82 -0.39 6.1e-11 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs367615 0.704 rs7705399 chr5:108850351 G/C cg17395555 chr5:108820864 NA 0.63 11.21 0.57 3.84e-24 Colorectal cancer (SNP x SNP interaction); CESC cis rs6120849 0.586 rs2025096 chr20:33540000 G/A cg24642439 chr20:33292090 TP53INP2 0.69 6.83 0.39 5.7e-11 Protein C levels; CESC cis rs763014 0.966 rs4144003 chr16:645968 C/T cg07343612 chr16:622815 PIGQ -0.55 -7.94 -0.44 5.64e-14 Height; CESC cis rs9611519 0.828 rs28814423 chr22:41452301 G/A cg03806693 chr22:41940476 POLR3H -0.57 -5.92 -0.34 1.01e-8 Neuroticism; CESC cis rs6460942 0.908 rs6948654 chr7:12418546 T/A cg02935154 chr7:12443704 VWDE -0.57 -6.42 -0.37 6.27e-10 Coronary artery disease; CESC cis rs644799 1.000 rs509720 chr11:95562771 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.27 0.66 1.19e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg22535103 chr8:58192502 C8orf71 -1.01 -12.77 -0.62 1.97e-29 Developmental language disorder (linguistic errors); CESC trans rs35110281 0.837 rs7279958 chr21:45016016 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 6.6 0.38 2.26e-10 Mean corpuscular volume; CESC trans rs116095464 0.558 rs2288459 chr5:231143 T/C cg00938859 chr5:1591904 SDHAP3 0.63 6.87 0.39 4.48e-11 Breast cancer; CESC cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg17366294 chr4:99064904 C4orf37 0.57 7.98 0.44 4.33e-14 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17498856 chr1:1457042 ATAD3A -0.6 -7.0 -0.4 2.13e-11 Gut microbiome composition (summer); CESC cis rs787274 0.619 rs58643876 chr9:115627285 C/A cg13803584 chr9:115635662 SNX30 -0.66 -5.84 -0.34 1.54e-8 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7017914 0.935 rs7826483 chr8:71702893 T/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.3 -0.31 2.38e-7 Bone mineral density; CESC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9467711 0.606 rs9393710 chr6:26367833 A/G cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC cis rs2979489 0.891 rs2979511 chr8:30394968 G/A cg26383811 chr8:30366931 RBPMS -0.81 -10.03 -0.52 2.89e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs10461617 0.512 rs7715746 chr5:56048837 C/T cg24549020 chr5:56110836 MAP3K1 0.43 5.09 0.3 6.95e-7 Type 2 diabetes; CESC cis rs9611565 0.506 rs4822020 chr22:41700203 C/T cg03806693 chr22:41940476 POLR3H -0.78 -8.92 -0.48 7.96e-17 Vitiligo; CESC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg11766577 chr21:47581405 C21orf56 -0.47 -6.43 -0.37 5.77e-10 Testicular germ cell tumor; CESC cis rs6121246 0.909 rs6119651 chr20:30259246 G/T cg13852791 chr20:30311386 BCL2L1 0.77 8.15 0.45 1.44e-14 Mean corpuscular hemoglobin; CESC cis rs7618501 0.521 rs3796386 chr3:49899795 G/A cg24308560 chr3:49941425 MST1R -0.64 -9.29 -0.5 5.76e-18 Intelligence (multi-trait analysis); CESC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg04287289 chr16:89883240 FANCA 0.93 16.27 0.71 9.74e-42 Vitiligo; CESC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs11958404 0.615 rs7717235 chr5:157447772 C/G cg05962755 chr5:157440814 NA 0.38 5.67 0.33 3.75e-8 IgG glycosylation; CESC cis rs78366141 0.649 rs61737091 chr4:89671721 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.75 5.34 0.31 1.97e-7 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs7605827 0.897 rs2380650 chr2:15533689 T/C cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs12478296 0.792 rs6740738 chr2:243007368 A/C cg06360820 chr2:242988706 NA -0.73 -8.84 -0.48 1.36e-16 Obesity-related traits; CESC cis rs7084402 0.905 rs7098329 chr10:60276915 C/T cg07615347 chr10:60278583 BICC1 -0.59 -9.42 -0.5 2.24e-18 Refractive error; CESC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -5.69 -0.33 3.45e-8 Tonsillectomy; CESC cis rs6500395 1.000 rs9931123 chr16:48614293 G/T cg04672837 chr16:48644449 N4BP1 0.51 6.5 0.37 3.95e-10 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26480745 chr17:7184899 SLC2A4 -0.58 -6.65 -0.38 1.69e-10 Gut microbiome composition (summer); CESC cis rs4481887 0.708 rs6688853 chr1:248548006 G/A cg26353448 chr1:248524236 OR2T4 -0.38 -5.37 -0.31 1.68e-7 Common traits (Other); CESC cis rs11030122 0.702 rs995498 chr11:3967791 A/G cg18678763 chr11:4115507 RRM1 -0.5 -6.64 -0.38 1.78e-10 Mean platelet volume;Platelet distribution width; CESC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg11843238 chr5:131593191 PDLIM4 0.36 5.32 0.31 2.2e-7 Breast cancer; CESC cis rs6142102 0.625 rs6141431 chr20:32540314 G/A cg08999081 chr20:33150536 PIGU 0.33 5.08 0.3 7.27e-7 Skin pigmentation; CESC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg22800045 chr5:56110881 MAP3K1 0.83 9.95 0.52 4.88e-20 Initial pursuit acceleration; CESC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs754466 0.580 rs10824573 chr10:79540969 T/C cg17075019 chr10:79541650 NA -0.88 -14.04 -0.65 7.39e-34 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs208520 0.837 rs208489 chr6:66927584 G/A cg07460842 chr6:66804631 NA -0.88 -10.57 -0.54 5.07e-22 Exhaled nitric oxide output; CESC cis rs7923609 0.935 rs10995477 chr10:65010672 T/C cg01631684 chr10:65280961 REEP3 -0.44 -5.51 -0.32 8.45e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs11098499 0.863 rs3775858 chr4:120486028 A/G cg25214090 chr10:38739885 LOC399744 0.67 9.14 0.49 1.7e-17 Corneal astigmatism; CESC cis rs3126085 0.877 rs11204968 chr1:152250211 A/T cg03465714 chr1:152285911 FLG -0.45 -5.56 -0.32 6.52e-8 Atopic dermatitis; CESC cis rs9287719 0.967 rs728281 chr2:10750355 T/C cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC cis rs8060686 0.641 rs7201742 chr16:68099821 T/G cg26727032 chr16:67993705 SLC12A4 -0.53 -6.41 -0.37 6.68e-10 HDL cholesterol;Metabolic syndrome; CESC cis rs12936587 0.535 rs8065154 chr17:17614947 A/G cg04398451 chr17:18023971 MYO15A -0.38 -5.07 -0.3 7.36e-7 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CESC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg14829155 chr15:31115871 NA 0.72 9.61 0.51 5.97e-19 Huntington's disease progression; CESC cis rs703842 1.000 rs11172344 chr12:58193448 T/C cg18357645 chr12:58087776 OS9 -0.39 -5.56 -0.32 6.57e-8 Multiple sclerosis; CESC cis rs6831352 1.000 rs10017466 chr4:100055800 C/T cg13256891 chr4:100009986 ADH5 0.63 7.47 0.42 1.19e-12 Alcohol dependence; CESC cis rs763121 0.853 rs5757208 chr22:39049230 A/C cg14440974 chr22:39074834 NA -0.4 -5.49 -0.32 9.53e-8 Menopause (age at onset); CESC cis rs12136530 0.651 rs12140654 chr1:19716801 C/T cg01832549 chr1:19774989 CAPZB -0.41 -5.72 -0.33 2.91e-8 Lead levels in blood; CESC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg11764359 chr7:65958608 NA 0.94 14.73 0.67 2.83e-36 Aortic root size; CESC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg11764359 chr7:65958608 NA -0.79 -11.41 -0.57 8.63e-25 Aortic root size; CESC cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.95 9.17 0.49 1.4e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.64 -8.54 -0.46 1.04e-15 Menopause (age at onset); CESC cis rs6474412 1.000 rs7004381 chr8:42551161 A/G cg25026480 chr8:42547641 NA 0.33 5.23 0.31 3.43e-7 Smoking behavior; CESC cis rs7264396 0.635 rs6058358 chr20:34492560 A/T cg17201900 chr20:34330562 RBM39 0.49 5.1 0.3 6.63e-7 Total cholesterol levels; CESC cis rs17401966 1.000 rs17401924 chr1:10384439 A/G cg15208524 chr1:10270712 KIF1B 0.49 6.3 0.36 1.25e-9 Hepatocellular carcinoma; CESC cis rs548181 0.545 rs4486648 chr11:125610589 T/A cg03464685 chr11:125439445 EI24 -0.69 -6.05 -0.35 5.02e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9815354 1.000 rs1716676 chr3:41903208 T/C cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.46e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs34375054 0.573 rs12581367 chr12:125654641 T/C cg25124228 chr12:125621409 AACS -0.51 -5.66 -0.33 3.98e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs12912251 0.894 rs7183893 chr15:38996981 A/C cg01338139 chr15:38987640 C15orf53 -0.51 -5.65 -0.33 4.06e-8 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs3768617 0.510 rs1547712 chr1:183088013 T/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.49e-35 Fuchs's corneal dystrophy; CESC cis rs1005277 0.540 rs2145487 chr10:38010077 A/G cg25517755 chr10:38738941 LOC399744 -0.4 -5.13 -0.3 5.53e-7 Extrinsic epigenetic age acceleration; CESC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg24531977 chr5:56204891 C5orf35 -0.87 -10.87 -0.56 5.43e-23 Initial pursuit acceleration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg07355693 chr12:125667907 NA -0.4 -6.43 -0.37 5.99e-10 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07511080 chr5:2749715 IRX2 -0.54 -6.67 -0.38 1.45e-10 Gut microbiome composition (summer); CESC cis rs17601876 0.814 rs8042086 chr15:51561478 C/T cg19946085 chr15:51559439 CYP19A1 -0.33 -5.37 -0.31 1.76e-7 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CESC cis rs698833 0.852 rs698768 chr2:44576549 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.9 0.34 1.1e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs13064411 0.696 rs7613546 chr3:113228019 G/A cg18753928 chr3:113234510 CCDC52 -0.5 -6.13 -0.35 3.23e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg15555402 chr12:19593456 AEBP2 0.47 6.31 0.36 1.15e-9 Breast cancer;Type 2 diabetes; CESC trans rs7904368 0.901 rs7923189 chr10:16850214 C/T cg14916108 chr12:2027993 CACNA2D4 -0.34 -6.06 -0.35 4.54e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg04553112 chr3:125709451 NA -0.54 -5.82 -0.34 1.71e-8 Blood pressure (smoking interaction); CESC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg00106254 chr7:1943704 MAD1L1 -0.47 -5.82 -0.34 1.7e-8 Bipolar disorder and schizophrenia; CESC cis rs6694270 0.529 rs12565650 chr1:19108355 G/A cg19637330 chr1:19110922 NA -0.52 -6.4 -0.37 6.86e-10 Drug-induced liver injury (nitrofurantoin); CESC cis rs9303401 0.659 rs17741087 chr17:56550300 C/T cg12560992 chr17:57184187 TRIM37 0.51 5.08 0.3 7.08e-7 Cognitive test performance; CESC cis rs2637266 1.000 rs2395387 chr10:78357029 T/C cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.49e-13 Pulmonary function; CESC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg11366901 chr6:160182831 ACAT2 0.64 8.17 0.45 1.24e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs1008375 0.966 rs6839660 chr4:17667987 C/T cg16339924 chr4:17578868 LAP3 0.52 6.6 0.38 2.17e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg27535305 chr1:53392650 SCP2 0.32 5.14 0.3 5.39e-7 Monocyte count; CESC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg12463550 chr7:65579703 CRCP 0.49 6.26 0.36 1.56e-9 Aortic root size; CESC cis rs7818382 0.967 rs7812465 chr8:96050557 C/T cg23172400 chr8:95962367 TP53INP1 0.37 7.61 0.42 4.74e-13 Alzheimer's disease (late onset); CESC cis rs731174 0.959 rs11264092 chr1:38190625 T/C cg06917450 chr1:38156652 C1orf109 -0.43 -5.34 -0.31 1.97e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs10200159 1.000 rs3748955 chr2:55853470 G/C cg13617705 chr2:55845095 SMEK2 0.7 5.22 0.31 3.53e-7 Vitiligo; CESC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg03647317 chr4:187891568 NA -0.43 -6.69 -0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg23074401 chr11:108535840 DDX10 -0.46 -6.56 -0.37 2.77e-10 Vertical cup-disc ratio; CESC cis rs8180040 0.966 rs3736177 chr3:47451411 C/T cg27129171 chr3:47204927 SETD2 -0.64 -9.86 -0.52 1e-19 Colorectal cancer; CESC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg15556689 chr8:8085844 FLJ10661 0.45 5.71 0.33 3.03e-8 Mood instability; CESC trans rs11098499 0.738 rs34566984 chr4:120361270 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg00149659 chr3:10157352 C3orf10 -0.6 -6.31 -0.36 1.16e-9 Alzheimer's disease; CESC cis rs863345 0.604 rs11264999 chr1:158488860 T/C cg12129480 chr1:158549410 OR10X1 -0.36 -7.09 -0.4 1.2e-11 Pneumococcal bacteremia; CESC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.94 -0.59 1.36e-26 Alzheimer's disease; CESC cis rs7647973 1.000 rs6783003 chr3:49524778 G/C cg07636037 chr3:49044803 WDR6 -0.7 -9.53 -0.51 1.06e-18 Menarche (age at onset); CESC cis rs6580649 1.000 rs6580647 chr12:48403229 G/T cg24011408 chr12:48396354 COL2A1 -0.4 -5.46 -0.32 1.07e-7 Lung cancer; CESC cis rs9329289 0.632 rs2452187 chr10:2551147 C/G cg05625103 chr10:2543513 NA 0.52 7.16 0.4 7.91e-12 Age-related hearing impairment; CESC cis rs116095464 0.558 rs55664502 chr5:270485 T/C cg22496380 chr5:211416 CCDC127 -0.73 -8.47 -0.46 1.75e-15 Breast cancer; CESC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg15145296 chr3:125709740 NA -0.56 -5.97 -0.34 7.65e-9 Blood pressure (smoking interaction); CESC cis rs7927771 1.000 rs7105282 chr11:47805614 C/A cg18512352 chr11:47633146 NA -0.61 -9.65 -0.51 4.46e-19 Subjective well-being; CESC cis rs7312774 0.618 rs73385161 chr12:107300164 G/A cg16260113 chr12:107380972 MTERFD3 0.64 6.12 0.35 3.43e-9 Severe influenza A (H1N1) infection; CESC cis rs9715521 0.900 rs62301182 chr4:59834267 A/G cg11281224 chr4:60001000 NA -0.51 -6.74 -0.38 9.64e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12830119 chr14:100154292 CYP46A1 -0.55 -6.43 -0.37 5.77e-10 Gut microbiome composition (summer); CESC cis rs4588572 0.570 rs2115433 chr5:77700363 C/T cg11547950 chr5:77652471 NA -0.4 -5.61 -0.33 5.13e-8 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24460917 chr20:18269097 ZNF133 0.7 8.16 0.45 1.35e-14 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg08882774 chr16:28875105 SH2B1 -0.44 -6.03 -0.35 5.38e-9 Asthma; CESC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg23048001 chr7:2026167 MAD1L1 -0.49 -6.39 -0.37 7.43e-10 Bipolar disorder and schizophrenia; CESC cis rs9611519 0.929 rs9611469 chr22:41433319 T/C cg03806693 chr22:41940476 POLR3H -0.57 -5.94 -0.34 9.05e-9 Neuroticism; CESC cis rs10751667 0.600 rs7950955 chr11:1011490 G/A cg01483505 chr11:975446 AP2A2 0.43 5.55 0.32 7.09e-8 Alzheimer's disease (late onset); CESC cis rs950776 0.518 rs12914694 chr15:78814444 G/A cg06917634 chr15:78832804 PSMA4 0.78 11.4 0.57 9.32e-25 Sudden cardiac arrest; CESC cis rs9815354 0.597 rs80066790 chr3:42000843 A/G cg03022575 chr3:42003672 ULK4 0.64 5.83 0.34 1.62e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg22535103 chr8:58192502 C8orf71 -0.81 -9.13 -0.49 1.82e-17 Developmental language disorder (linguistic errors); CESC cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg25554036 chr4:6271136 WFS1 -0.53 -8.79 -0.48 1.89e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg05347473 chr6:146136440 FBXO30 0.55 6.82 0.39 6.21e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.909 rs28555550 chr4:120211040 C/G cg24375607 chr4:120327624 NA 0.42 5.03 0.3 8.94e-7 Corneal astigmatism; CESC cis rs1008375 1.000 rs10009541 chr4:17682218 C/T cg16339924 chr4:17578868 LAP3 -0.56 -6.89 -0.39 4.17e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs523522 0.962 rs7136951 chr12:120941927 C/T cg27279351 chr12:120934652 DYNLL1 0.69 8.94 0.48 6.79e-17 High light scatter reticulocyte count; CESC cis rs1943345 1.000 rs1943345 chr11:82876270 G/T cg07047830 chr11:82868014 PCF11 -0.57 -7.13 -0.4 9.57e-12 Obesity-related traits; CESC cis rs9814567 1.000 rs13059720 chr3:134242021 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.08 0.35 4.21e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs6754311 0.517 rs1469995 chr2:136542559 G/A cg07169764 chr2:136633963 MCM6 0.99 12.69 0.61 3.67e-29 Mosquito bite size; CESC cis rs501120 1.000 rs671765 chr10:44752976 A/G cg09554077 chr10:44749378 NA 0.5 6.28 0.36 1.4e-9 Coronary artery disease;Coronary heart disease; CESC cis rs367943 0.712 rs27567 chr5:112741798 C/T cg12552261 chr5:112820674 MCC 0.4 5.32 0.31 2.17e-7 Type 2 diabetes; CESC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg02187348 chr16:89574699 SPG7 0.67 9.61 0.51 6.07e-19 Multiple myeloma (IgH translocation); CESC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg04944784 chr2:26401820 FAM59B 0.96 10.55 0.54 5.79e-22 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03520265 chr6:138785472 NHSL1 -0.51 -6.42 -0.37 6.16e-10 Gut microbiome composition (summer); CESC cis rs116988415 0.584 rs2269307 chr14:65245007 G/A cg25083366 chr14:65239357 SPTB 0.71 5.23 0.31 3.44e-7 Daytime sleep phenotypes; CESC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg01988459 chr11:68622903 NA -0.39 -5.42 -0.32 1.31e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13064411 0.696 rs9860549 chr3:113148368 G/A cg18753928 chr3:113234510 CCDC52 -0.47 -5.56 -0.32 6.63e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC trans rs11992162 0.636 rs4841645 chr8:11798684 G/T cg15556689 chr8:8085844 FLJ10661 -0.51 -6.29 -0.36 1.34e-9 Monocyte count; CESC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg20151795 chr6:28129481 ZNF389 0.36 5.23 0.31 3.44e-7 Cardiac Troponin-T levels; CESC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs3092073 0.624 rs7275164 chr20:44604822 G/A cg27529037 chr20:44575021 PCIF1 0.65 9.67 0.51 3.83e-19 Intelligence (multi-trait analysis); CESC cis rs4975616 0.869 rs455433 chr5:1336243 A/G cg26373071 chr5:1325741 CLPTM1L 0.43 6.88 0.39 4.26e-11 Lung cancer; CESC cis rs7100689 0.646 rs11202751 chr10:82147802 G/A cg00277334 chr10:82204260 NA -0.58 -7.62 -0.42 4.52e-13 Post bronchodilator FEV1; CESC cis rs1801251 1.000 rs6745879 chr2:233590007 A/G cg25237894 chr2:233734115 C2orf82 0.48 8.19 0.45 1.08e-14 Coronary artery disease; CESC cis rs7599312 0.534 rs10182996 chr2:213404834 T/C cg20637307 chr2:213403960 ERBB4 0.57 8.92 0.48 7.78e-17 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg07092213 chr7:1199455 ZFAND2A -0.48 -5.28 -0.31 2.67e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg03709012 chr19:19516395 GATAD2A -0.96 -14.11 -0.66 4.09e-34 Tonsillectomy; CESC trans rs11021065 0.764 rs10765714 chr11:94913701 T/A cg04819096 chr12:54339167 HOXC13 -0.24 -6.21 -0.36 2e-9 Common carotid intima-media thickness in HIV infection;Common carotid intima-media thickness; CESC cis rs2404602 0.716 rs4886813 chr15:76838221 C/T cg22467129 chr15:76604101 ETFA 0.36 5.53 0.32 7.66e-8 Blood metabolite levels; CESC cis rs6087990 0.735 rs6058892 chr20:31388461 C/T cg13636640 chr20:31349939 DNMT3B 0.77 12.28 0.6 9.43e-28 Ulcerative colitis; CESC cis rs7824557 0.527 rs2736305 chr8:11237773 T/C cg21775007 chr8:11205619 TDH -0.53 -8.05 -0.44 2.85e-14 Retinal vascular caliber; CESC cis rs644799 0.526 rs693172 chr11:95636618 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.48 6.37 0.36 8.28e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs1814175 0.676 rs1721999 chr11:49917372 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC trans rs7615952 0.932 rs13325495 chr3:125637416 T/G cg07211511 chr3:129823064 LOC729375 -1.11 -13.83 -0.65 3.93e-33 Blood pressure (smoking interaction); CESC cis rs7666738 0.546 rs28444809 chr4:98916934 C/T cg05340658 chr4:99064831 C4orf37 0.54 6.47 0.37 4.73e-10 Colonoscopy-negative controls vs population controls; CESC cis rs10214930 0.560 rs42089 chr7:27702940 C/T cg05786569 chr7:27702416 HIBADH -0.46 -6.04 -0.35 5.11e-9 Hypospadias; CESC trans rs1029576 0.861 rs1029578 chr7:17065815 T/C cg03113285 chr6:46098122 ENPP4 -0.42 -6.04 -0.35 5.16e-9 Residual cognition; CESC cis rs4969178 0.965 rs2292642 chr17:76395430 C/T cg20026190 chr17:76395443 PGS1 0.49 7.73 0.43 2.17e-13 HDL cholesterol levels; CESC trans rs1814175 0.817 rs7109440 chr11:49966296 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -20.41 -0.78 2.75e-56 Height; CESC cis rs244293 1.000 rs244296 chr17:53242878 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.05 -0.3 8.15e-7 Menarche (age at onset); CESC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg21285383 chr16:89894308 SPIRE2 -0.3 -5.45 -0.32 1.13e-7 Vitiligo; CESC cis rs1691799 0.899 rs1168314 chr12:66746937 A/G cg16791601 chr12:66731901 HELB -0.79 -14.43 -0.66 3.27e-35 White blood cell count (basophil); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09365624 chr1:87597710 LOC339524 -0.47 -7.08 -0.4 1.26e-11 Gambling; CESC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg11890956 chr21:40555474 PSMG1 1.17 21.55 0.8 3.39e-60 Cognitive function; CESC cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg22633769 chr20:60982531 CABLES2 0.53 5.53 0.32 7.56e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs10876993 0.890 rs10783844 chr12:58098425 A/C cg18357645 chr12:58087776 OS9 0.63 10.41 0.54 1.74e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs7923609 0.967 rs7085018 chr10:65286667 T/C cg01631684 chr10:65280961 REEP3 -0.44 -5.53 -0.32 7.8e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7582720 1.000 rs74421437 chr2:203831252 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg03188948 chr7:1209495 NA 0.69 7.66 0.43 3.45e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2228479 0.764 rs11641201 chr16:89983276 T/C cg04013166 chr16:89971882 TCF25 0.76 8.43 0.46 2.22e-15 Skin colour saturation; CESC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg14393609 chr7:65229607 NA 0.48 6.55 0.37 2.89e-10 Calcium levels; CESC cis rs1882538 0.569 rs11562036 chr7:133076862 T/C cg10665199 chr7:133106180 EXOC4 0.58 8.03 0.44 3.29e-14 Intelligence (multi-trait analysis); CESC cis rs887829 0.569 rs4294999 chr2:234635467 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.53 -7.32 -0.41 3e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg08564027 chr20:61660810 NA 0.9 15.44 0.69 8.75e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03576123 chr11:487126 PTDSS2 -1.06 -10.99 -0.56 2.1e-23 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17482197 chr20:56285683 PMEPA1 0.58 6.28 0.36 1.37e-9 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg06873352 chr17:61820015 STRADA 0.47 6.86 0.39 4.85e-11 Height; CESC cis rs4450798 0.649 rs73137996 chr3:13771796 C/A cg05589046 chr3:13742034 LOC285375 0.34 5.15 0.3 5e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06774618 chr1:24117530 LYPLA2 0.61 6.67 0.38 1.49e-10 Gut microbiome composition (summer); CESC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.14 -0.3 5.22e-7 Lung cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08120044 chr21:42539440 BACE2 -0.49 -6.16 -0.35 2.69e-9 Ulcerative colitis; CESC cis rs9910055 0.552 rs4793084 chr17:42317371 G/T cg08499158 chr17:42289980 UBTF 0.49 6.06 0.35 4.68e-9 Total body bone mineral density; CESC cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg05340658 chr4:99064831 C4orf37 0.66 9.01 0.48 4.1e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2280018 0.526 rs2966129 chr16:15152927 A/C cg07549590 chr16:15018862 NA 0.59 9.62 0.51 5.55e-19 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs7917772 0.536 rs17783771 chr10:104410736 C/T cg22532475 chr10:104410764 TRIM8 -0.43 -6.61 -0.38 2.06e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7615952 0.736 rs11921945 chr3:125643719 A/G cg05084668 chr3:125655381 ALG1L -0.44 -5.28 -0.31 2.72e-7 Blood pressure (smoking interaction); CESC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg08027265 chr7:2291960 NA 0.44 6.7 0.38 1.24e-10 Bipolar disorder and schizophrenia; CESC cis rs13102973 0.965 rs6535050 chr4:135874115 A/C cg14419869 chr4:135874104 NA -0.38 -5.88 -0.34 1.24e-8 Subjective well-being; CESC cis rs9309473 0.632 rs6546825 chr2:73592253 G/C cg20560298 chr2:73613845 ALMS1 -0.44 -5.86 -0.34 1.39e-8 Metabolite levels; CESC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg24881330 chr22:46731750 TRMU 0.78 6.83 0.39 5.79e-11 LDL cholesterol;Cholesterol, total; CESC cis rs1348850 0.561 rs4893956 chr2:178373452 C/T cg22681709 chr2:178499509 PDE11A -0.5 -5.26 -0.31 2.97e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs60843830 1.000 rs4497901 chr2:239969 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.88 12.15 0.6 2.63e-27 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg04369109 chr6:150039330 LATS1 -0.39 -5.43 -0.32 1.28e-7 Lung cancer; CESC cis rs4700695 0.545 rs29441 chr5:65509116 G/T cg21114390 chr5:65439923 SFRS12 -0.47 -5.67 -0.33 3.82e-8 Facial morphology (factor 19); CESC cis rs1372520 0.506 rs356198 chr4:90682504 C/T cg15133208 chr4:90757351 SNCA 0.43 5.12 0.3 5.78e-7 Neuroticism; CESC trans rs9852859 0.530 rs71316820 chr3:85958279 G/C cg10416071 chr15:75628863 COMMD4 0.63 6.19 0.36 2.22e-9 Body mass index; CESC cis rs3796352 0.881 rs13100714 chr3:53074824 T/G cg12962167 chr3:53033115 SFMBT1 0.61 5.09 0.3 6.68e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg00080972 chr5:178986291 RUFY1 -0.47 -7.74 -0.43 2.12e-13 Lung cancer; CESC cis rs4909189 1.000 rs62493650 chr7:158135570 G/T cg24154853 chr7:158122151 PTPRN2 0.46 6.2 0.36 2.22e-9 Response to amphetamines; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05415724 chr2:113033170 ZC3H6 -0.46 -6.0 -0.35 6.45e-9 Ulcerative colitis; CESC cis rs6598163 0.700 rs12813179 chr12:132302228 C/G cg10319629 chr12:132285459 NA 0.53 7.31 0.41 3.06e-12 Migraine; CESC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg18016565 chr1:150552671 MCL1 0.33 5.13 0.3 5.67e-7 Tonsillectomy; CESC cis rs3733585 0.605 rs4697926 chr4:10124567 G/T cg00071950 chr4:10020882 SLC2A9 0.64 9.79 0.52 1.64e-19 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg03582285 chr17:40700314 NA -0.39 -5.74 -0.33 2.63e-8 Colorectal or endometrial cancer; CESC cis rs7666738 0.546 rs10025064 chr4:98914060 A/G cg05340658 chr4:99064831 C4orf37 0.6 7.49 0.42 1.06e-12 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs501120 1.000 rs487465 chr10:44758197 A/C cg09554077 chr10:44749378 NA 0.52 6.91 0.39 3.59e-11 Coronary artery disease;Coronary heart disease; CESC cis rs2204008 0.657 rs8186888 chr12:38334260 T/G cg26384229 chr12:38710491 ALG10B 0.5 7.13 0.4 9.41e-12 Bladder cancer; CESC cis rs9834373 0.853 rs2314126 chr3:78474658 A/C cg06138941 chr3:78371609 NA -0.44 -5.3 -0.31 2.45e-7 Protein quantitative trait loci; CESC cis rs2180341 0.920 rs4472373 chr6:127705983 G/A cg27446573 chr6:127587934 RNF146 1.04 14.9 0.68 6.79e-37 Breast cancer; CESC trans rs4906172 0.773 rs941792 chr14:102514713 A/G cg17920195 chr4:129149383 NA -0.31 -6.08 -0.35 4.07e-9 Menopause (age at onset); CESC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg23262073 chr20:60523788 NA 0.53 7.1 0.4 1.17e-11 Obesity-related traits; CESC cis rs9303280 0.901 rs9303277 chr17:37976469 C/T cg19468946 chr17:37922297 IKZF3 -0.38 -5.37 -0.31 1.73e-7 Self-reported allergy; CESC cis rs870825 0.616 rs28608669 chr4:185632890 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.91 0.39 3.51e-11 Blood protein levels; CESC cis rs9487051 0.700 rs9400266 chr6:109596193 T/A cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC cis rs36051895 0.664 rs3780373 chr9:5098223 T/C cg02405213 chr9:5042618 JAK2 -0.5 -6.27 -0.36 1.48e-9 Pediatric autoimmune diseases; CESC cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs116095464 1.000 rs1567956 chr5:315616 C/A cg10591111 chr5:226296 SDHA -0.62 -5.75 -0.33 2.5e-8 Breast cancer; CESC cis rs56235845 0.796 rs13153019 chr5:176782218 T/C cg17509989 chr5:176798049 RGS14 0.76 8.01 0.44 3.67e-14 Hemoglobin concentration;Hematocrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22727364 chr8:126443014 TRIB1 0.54 6.57 0.37 2.65e-10 Gut microbiome composition (summer); CESC cis rs7249921 0.802 rs62111399 chr19:35668771 C/T cg15419183 chr19:35660584 FXYD5 0.56 8.27 0.45 6.54e-15 Platelet count; CESC cis rs11645898 0.935 rs11641721 chr16:72155241 G/A cg14768367 chr16:72042858 DHODH -0.66 -5.84 -0.34 1.56e-8 Blood protein levels; CESC cis rs4727027 0.704 rs12704083 chr7:148909759 G/A cg23583168 chr7:148888333 NA -0.93 -16.23 -0.71 1.38e-41 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17304635 chr2:2633447 NA 0.43 6.28 0.36 1.38e-9 Fibrinogen levels; CESC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.54 0.32 7.43e-8 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16196077 chr10:64028521 RTKN2 0.52 6.15 0.35 2.82e-9 Gut microbiome composition (summer); CESC cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg11764359 chr7:65958608 NA -0.67 -8.51 -0.46 1.32e-15 Aortic root size; CESC cis rs72781680 0.752 rs72796130 chr2:23919740 T/C cg08917208 chr2:24149416 ATAD2B 1.13 10.24 0.53 5.87e-21 Lymphocyte counts; CESC cis rs7296418 0.738 rs1568428 chr12:123738876 A/G cg05973401 chr12:123451056 ABCB9 -0.5 -6.5 -0.37 3.93e-10 Platelet count; CESC trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg03929089 chr4:120376271 NA -0.76 -10.97 -0.56 2.56e-23 Coronary artery disease; CESC cis rs4722166 0.532 rs1546763 chr7:22757843 G/A cg05472934 chr7:22766657 IL6 0.52 6.9 0.39 3.81e-11 Lung cancer; CESC cis rs2455799 0.613 rs2470549 chr3:15737698 T/C cg16303742 chr3:15540471 COLQ -0.36 -5.63 -0.33 4.5e-8 Mean platelet volume; CESC cis rs4664304 0.629 rs17239981 chr2:160847667 C/T cg03641300 chr2:160917029 PLA2R1 -0.43 -5.82 -0.34 1.69e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs763121 0.853 rs926299 chr22:39095698 C/G cg06544989 chr22:39130855 UNC84B 0.52 9.88 0.52 8.35e-20 Menopause (age at onset); CESC cis rs13095912 1.000 rs1823238 chr3:185341970 G/A cg11274856 chr3:185301563 NA 0.32 5.13 0.3 5.67e-7 Systolic blood pressure; CESC cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.43 -5.78 -0.33 2.11e-8 Colorectal cancer; CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.48 -6.32 -0.36 1.09e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9486719 1.000 rs3906199 chr6:97049899 C/A cg06623918 chr6:96969491 KIAA0776 -0.83 -8.62 -0.47 6.02e-16 Migraine;Coronary artery disease; CESC cis rs66887589 0.870 rs59590064 chr4:120539753 T/C cg09307838 chr4:120376055 NA -0.46 -6.27 -0.36 1.42e-9 Diastolic blood pressure; CESC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs6831352 0.918 rs17218073 chr4:100055739 G/A cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg24578937 chr1:2090814 PRKCZ -0.32 -5.78 -0.33 2.07e-8 Height; CESC cis rs2072732 0.861 rs12039132 chr1:2949355 C/T cg15211996 chr1:2936768 ACTRT2 0.35 6.12 0.35 3.42e-9 Plateletcrit; CESC cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg21918786 chr6:109611834 NA -0.37 -5.53 -0.32 7.72e-8 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00975115 chr16:30958403 FBXL19 -0.62 -6.46 -0.37 4.91e-10 Gut microbiome composition (summer); CESC cis rs7561273 0.565 rs6545275 chr2:24331860 A/G cg01493198 chr2:24299560 SF3B14 0.41 5.05 0.3 8.11e-7 Quantitative traits; CESC cis rs6964587 0.692 rs6953256 chr7:91575417 C/T cg17063962 chr7:91808500 NA -0.45 -6.32 -0.36 1.13e-9 Breast cancer; CESC trans rs1887596 0.624 rs9553858 chr13:27138472 A/G cg19523213 chr12:21927973 KCNJ8 -0.36 -6.0 -0.35 6.41e-9 Facial morphology (factor 3, length of philtrum); CESC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg18904891 chr8:8559673 CLDN23 0.69 7.94 0.44 5.6e-14 Obesity-related traits; CESC cis rs858239 0.899 rs2268747 chr7:23313462 A/G cg23682824 chr7:23144976 KLHL7 0.44 5.58 0.32 5.93e-8 Cerebrospinal fluid biomarker levels; CESC cis rs6499255 0.951 rs11639947 chr16:69646122 C/T cg15192750 chr16:69999425 NA 0.55 6.47 0.37 4.59e-10 IgE levels; CESC cis rs698813 0.604 rs2340814 chr2:44490977 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.6 0.33 5.26e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg04234412 chr22:24373322 LOC391322 0.52 7.14 0.4 9e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2710642 0.611 rs6705835 chr2:62870408 C/T cg17519650 chr2:63277830 OTX1 0.45 5.32 0.31 2.24e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs2337406 0.714 rs7152055 chr14:107227228 C/T cg23076370 chr14:107095027 NA -0.53 -5.15 -0.3 5.01e-7 Alzheimer's disease (late onset); CESC cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg24829409 chr8:58192753 C8orf71 0.64 7.44 0.42 1.37e-12 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.779 rs28495013 chr4:120375831 A/C cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs7503807 0.905 rs62068345 chr17:78608040 C/T cg09596252 chr17:78655493 RPTOR 0.52 7.66 0.43 3.49e-13 Obesity; CESC cis rs12541635 0.966 rs11786829 chr8:107023752 C/G cg10147462 chr8:107024639 NA 0.42 6.05 0.35 4.79e-9 Age of smoking initiation; CESC cis rs12477438 1.000 rs6732980 chr2:99921613 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.15 -0.4 8.59e-12 Chronic sinus infection; CESC cis rs3733585 0.699 rs4621431 chr4:9947590 C/T cg11266682 chr4:10021025 SLC2A9 -0.59 -10.12 -0.53 1.39e-20 Cleft plate (environmental tobacco smoke interaction); CESC cis rs116095464 0.558 rs28558836 chr5:285748 C/G cg10591111 chr5:226296 SDHA -0.52 -6.31 -0.36 1.17e-9 Breast cancer; CESC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg04267008 chr7:1944627 MAD1L1 -0.62 -7.42 -0.41 1.57e-12 Bipolar disorder and schizophrenia; CESC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg18240062 chr17:79603768 NPLOC4 -0.54 -7.18 -0.4 7.17e-12 Eye color traits; CESC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg24846343 chr22:24311635 DDTL 0.63 11.04 0.56 1.43e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg27170947 chr2:26402098 FAM59B -0.87 -9.87 -0.52 9.27e-20 Gut microbiome composition (summer); CESC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg16325326 chr1:53192061 ZYG11B -0.89 -15.32 -0.69 2.26e-38 Monocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06972998 chr10:76585851 MYST4 0.47 6.45 0.37 5.38e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg00166722 chr3:10149974 C3orf24 0.47 5.95 0.34 8.68e-9 Alzheimer's disease; CESC trans rs2099077 0.867 rs12518613 chr5:102788222 C/T cg07434438 chr16:72961899 ZFHX3 0.49 6.67 0.38 1.52e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs3812565 0.530 rs10781538 chr9:139320929 C/G cg14019695 chr9:139328340 INPP5E -0.34 -5.23 -0.31 3.39e-7 Granulocyte percentage of myeloid white cells; CESC cis rs4523957 0.583 rs923864 chr17:2031507 C/T cg16513277 chr17:2031491 SMG6 -0.79 -11.73 -0.58 6.95e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs3008870 0.959 rs1886686 chr1:67390468 C/G cg08660285 chr1:67390436 MIER1;WDR78 1.04 14.42 0.66 3.56e-35 Lymphocyte percentage of white cells; CESC trans rs208520 0.874 rs208514 chr6:66945520 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.81 -9.4 -0.5 2.72e-18 Exhaled nitric oxide output; CESC cis rs62103177 0.564 rs1715230 chr18:77848002 C/T cg12964065 chr18:77638022 KCNG2 0.48 5.68 0.33 3.52e-8 Opioid sensitivity; CESC cis rs7833986 0.501 rs9650314 chr8:56903610 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.09 0.4 1.2e-11 Height; CESC cis rs477692 0.563 rs7079165 chr10:131430240 G/A cg26102564 chr10:131424627 MGMT -0.34 -5.09 -0.3 6.71e-7 Response to temozolomide; CESC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg12564285 chr5:131593104 PDLIM4 0.4 6.06 0.35 4.61e-9 Breast cancer; CESC cis rs472402 0.580 rs7720479 chr5:6640049 A/G cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.54 -7.03 -0.4 1.8e-11 Response to amphetamines; CESC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg21782813 chr7:2030301 MAD1L1 0.49 6.96 0.39 2.69e-11 Schizophrenia, schizoaffective disorder or bipolar disorder; CESC cis rs73206853 0.702 rs7960516 chr12:110529238 T/A cg12870014 chr12:110450643 ANKRD13A 0.61 6.11 0.35 3.47e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg17366294 chr4:99064904 C4orf37 0.64 8.96 0.48 6.14e-17 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18468176 chr14:95623969 FLJ45244;DICER1 -0.56 -7.32 -0.41 3.04e-12 Gut microbiota (bacterial taxa); CESC cis rs12681288 0.823 rs2701906 chr8:1003316 T/C cg04851639 chr8:1020857 NA -0.34 -7.47 -0.42 1.14e-12 Schizophrenia; CESC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg23708337 chr7:1209742 NA 0.5 5.41 0.32 1.38e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6750047 0.515 rs13417487 chr2:38289162 G/T cg07380506 chr2:38303506 CYP1B1 0.41 5.25 0.31 3.11e-7 Cutaneous malignant melanoma;Melanoma; CESC cis rs751837 0.591 rs12100549 chr14:103417030 C/T cg10087771 chr14:103399429 CDC42BPB 0.72 6.24 0.36 1.69e-9 Large B-cell lymphoma; CESC cis rs72781680 0.898 rs12623333 chr2:24111823 T/G cg20701182 chr2:24300061 SF3B14 0.64 5.79 0.34 1.97e-8 Lymphocyte counts; CESC cis rs7084402 1.000 rs7084402 chr10:60265404 C/T cg07615347 chr10:60278583 BICC1 0.56 8.65 0.47 5.12e-16 Refractive error; CESC trans rs2018683 0.707 rs917215 chr7:28971367 C/T cg19402173 chr7:128379420 CALU -0.54 -7.23 -0.41 5.32e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs6570726 0.935 rs7757387 chr6:145816726 G/T cg05347473 chr6:146136440 FBXO30 0.49 6.68 0.38 1.39e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg03517284 chr6:25882590 NA 0.43 5.97 0.34 7.79e-9 Intelligence (multi-trait analysis); CESC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.34 0.41 2.56e-12 Tonsillectomy; CESC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg22920501 chr2:26401640 FAM59B -0.69 -8.46 -0.46 1.82e-15 Gut microbiome composition (summer); CESC cis rs9584850 0.834 rs745639 chr13:99119279 C/T cg20750642 chr13:99100586 FARP1 -0.38 -5.84 -0.34 1.54e-8 Neuroticism; CESC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg11764359 chr7:65958608 NA -0.79 -11.05 -0.56 1.31e-23 Aortic root size; CESC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 8.33 0.46 4.25e-15 Platelet count; CESC cis rs12681366 0.708 rs3019279 chr8:95447905 G/C cg13257157 chr8:95487014 RAD54B 0.38 5.14 0.3 5.25e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg26354017 chr1:205819088 PM20D1 -0.46 -6.19 -0.36 2.22e-9 Parkinson's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17899198 chr3:127323650 MCM2 -0.53 -6.05 -0.35 4.95e-9 Gut microbiome composition (summer); CESC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg04414720 chr1:150670196 GOLPH3L 0.51 6.64 0.38 1.75e-10 Tonsillectomy; CESC cis rs17362650 0.883 rs35744046 chr2:9662410 T/C cg12832956 chr2:9616023 IAH1 -0.52 -5.11 -0.3 6.21e-7 Alcohol dependence (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06972998 chr10:76585851 MYST4 -0.63 -7.34 -0.41 2.57e-12 Gut microbiome composition (summer); CESC cis rs9611565 0.571 rs7364123 chr22:42216326 A/G cg03806693 chr22:41940476 POLR3H -0.73 -8.88 -0.48 1.07e-16 Vitiligo; CESC trans rs116095464 0.542 rs28650039 chr5:273954 C/A cg00938859 chr5:1591904 SDHAP3 0.65 6.98 0.39 2.31e-11 Breast cancer; CESC cis rs12824058 0.831 rs4759655 chr12:130815740 A/G cg26677194 chr12:130822605 PIWIL1 -0.53 -6.99 -0.39 2.23e-11 Menopause (age at onset); CESC cis rs5758511 0.637 rs5751244 chr22:42617411 T/C cg00645731 chr22:42541494 CYP2D7P1 0.57 8.44 0.46 2.14e-15 Birth weight; CESC cis rs8038465 0.874 rs11072434 chr15:74002854 A/G cg15420318 chr15:73925796 NPTN -0.39 -5.52 -0.32 8.07e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9287719 0.967 rs3815521 chr2:10743654 G/C cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs959260 0.925 rs1108355 chr17:73383913 A/T cg20590849 chr17:73267439 MIF4GD -0.61 -6.94 -0.39 3.07e-11 Systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19141861 chr12:120966964 COQ5 -0.44 -6.06 -0.35 4.7e-9 Fibrinogen levels; CESC trans rs7307889 1.000 rs73047647 chr12:6011088 A/G cg18407955 chr7:158110685 PTPRN2 -0.72 -6.32 -0.36 1.12e-9 Obesity-related traits; CESC cis rs3733585 0.577 rs28558552 chr4:9964913 G/A cg02734326 chr4:10020555 SLC2A9 -0.41 -5.54 -0.32 7.24e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7089973 0.604 rs7895830 chr10:116625776 A/G cg23260525 chr10:116636907 FAM160B1 0.42 8.12 0.45 1.8e-14 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6028335 0.502 rs8114962 chr20:37635979 A/G cg27552599 chr20:37590471 DHX35 0.39 5.67 0.33 3.72e-8 Alcohol and nicotine co-dependence; CESC cis rs4481887 0.927 rs12042598 chr1:248482016 C/T cg00666640 chr1:248458726 OR2T12 0.35 5.71 0.33 3.09e-8 Common traits (Other); CESC cis rs11098499 0.863 rs12498539 chr4:120468370 C/T cg09307838 chr4:120376055 NA 0.9 12.48 0.61 1.95e-28 Corneal astigmatism; CESC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs854765 0.893 rs712265 chr17:18008447 G/A cg04398451 chr17:18023971 MYO15A 0.68 9.32 0.5 4.58e-18 Total body bone mineral density; CESC cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg17366294 chr4:99064904 C4orf37 0.61 8.61 0.47 6.69e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4535700 0.543 rs2174459 chr7:55991293 T/C cg09872392 chr7:56161020 PHKG1 0.41 5.81 0.34 1.8e-8 Macular telangiectasia type 2; CESC cis rs1707322 0.821 rs11211182 chr1:46240170 G/A cg05343316 chr1:45956843 TESK2 0.49 5.92 0.34 9.7e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.74 10.22 0.53 6.66e-21 Total body bone mineral density; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11200644 chr18:72265018 LOC400657 0.48 6.32 0.36 1.11e-9 Systemic lupus erythematosus; CESC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg15921436 chr17:44337874 NA -0.44 -5.52 -0.32 8.23e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2243480 1.000 rs6958420 chr7:65751171 A/G cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC cis rs2637266 0.783 rs864676 chr10:78509385 A/G cg18941641 chr10:78392320 NA 0.43 8.41 0.46 2.58e-15 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01925393 chr1:24194307 FUCA1 0.53 6.1 0.35 3.71e-9 Gut microbiome composition (summer); CESC cis rs7659604 0.540 rs11724322 chr4:122697850 A/T cg19748678 chr4:122722346 EXOSC9 -0.45 -5.7 -0.33 3.15e-8 Type 2 diabetes; CESC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg27125505 chr17:43679177 LOC644172 0.51 6.58 0.37 2.46e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11608355 0.515 rs56244055 chr12:109936211 G/A cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg11644478 chr21:40555479 PSMG1 0.77 8.09 0.45 2.11e-14 Cognitive function; CESC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg23283495 chr1:209979779 IRF6 0.52 6.2 0.36 2.1e-9 Cleft lip with or without cleft palate; CESC cis rs2228479 0.867 rs75110337 chr16:89962635 C/A cg14709524 chr16:89940631 TCF25 0.72 5.45 0.32 1.16e-7 Skin colour saturation; CESC trans rs9929218 0.911 rs1075959 chr16:68832750 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.64 -8.03 -0.44 3.21e-14 Colorectal cancer; CESC cis rs2204008 0.643 rs1315347 chr12:38162494 C/T cg26384229 chr12:38710491 ALG10B -0.42 -5.74 -0.33 2.61e-8 Bladder cancer; CESC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg07701084 chr6:150067640 NUP43 0.48 6.85 0.39 5.03e-11 Lung cancer; CESC cis rs6695640 0.820 rs2489611 chr1:17759245 T/C cg01904812 chr1:17746340 RCC2 0.34 5.09 0.3 6.69e-7 Mean platelet volume; CESC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 6.51 0.37 3.83e-10 Personality dimensions; CESC cis rs9560113 0.573 rs61955236 chr13:112242861 G/A cg10483660 chr13:112241077 NA 0.44 7.31 0.41 3.18e-12 Menarche (age at onset); CESC cis rs2463822 1.000 rs7481995 chr11:62129312 G/C cg06239285 chr11:62104954 ASRGL1 0.86 8.63 0.47 5.79e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25774098 chr1:161359705 NA -0.51 -6.1 -0.35 3.82e-9 Ulcerative colitis; CESC cis rs4812048 0.649 rs6100319 chr20:57626568 A/C cg14073986 chr20:57617431 SLMO2 0.84 7.18 0.4 6.92e-12 Mean platelet volume; CESC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.31 0.57 1.8e-24 Alzheimer's disease; CESC cis rs9527 0.590 rs3861984 chr10:104916980 T/C cg04362960 chr10:104952993 NT5C2 0.44 5.42 0.32 1.34e-7 Arsenic metabolism; CESC cis rs561341 1.000 rs550923 chr17:30327013 G/C cg00745463 chr17:30367425 LRRC37B -0.82 -7.51 -0.42 9.09e-13 Hip circumference adjusted for BMI; CESC cis rs2404602 0.532 rs12591100 chr15:76700801 C/A cg23625390 chr15:77176239 SCAPER -0.36 -5.07 -0.3 7.5e-7 Blood metabolite levels; CESC cis rs7980687 0.627 rs1727325 chr12:123698332 G/C cg05973401 chr12:123451056 ABCB9 0.49 5.63 0.33 4.63e-8 Height;Educational attainment;Head circumference (infant); CESC cis rs9487051 0.652 rs9372210 chr6:109601703 G/C cg01475377 chr6:109611718 NA -0.45 -7.12 -0.4 1e-11 Reticulocyte fraction of red cells; CESC cis rs1832871 0.672 rs9457363 chr6:158777515 C/T cg07165851 chr6:158734300 TULP4 0.48 5.09 0.3 6.94e-7 Height; CESC cis rs6831352 0.703 rs4235435 chr4:100039578 C/T cg12011299 chr4:100065546 ADH4 0.57 6.88 0.39 4.34e-11 Alcohol dependence; CESC cis rs62229266 0.773 rs878606 chr21:37406692 G/A cg12218747 chr21:37451666 NA -0.46 -6.44 -0.37 5.46e-10 Mitral valve prolapse; CESC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.61 -0.33 4.97e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7267979 1.000 rs6138572 chr20:25435934 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.34 0.69 1.94e-38 Liver enzyme levels (alkaline phosphatase); CESC cis rs55871839 0.708 rs4738733 chr8:59813760 T/C cg07426533 chr8:59803705 TOX -0.47 -7.01 -0.4 1.95e-11 Pneumonia; CESC cis rs2952156 0.959 rs2952151 chr17:37828496 T/C cg20243544 chr17:37824526 PNMT 0.63 7.86 0.43 9.51e-14 Asthma; CESC cis rs9733 0.744 rs12758227 chr1:150844583 C/A cg22823121 chr1:150693482 HORMAD1 -0.37 -5.45 -0.32 1.15e-7 Tonsillectomy; CESC cis rs3793683 0.597 rs2182620 chr10:134590715 C/T cg18305652 chr10:134549665 INPP5A 0.48 6.82 0.39 6.13e-11 Migraine; CESC cis rs7666738 0.830 rs13148363 chr4:98847498 T/C cg17366294 chr4:99064904 C4orf37 0.51 6.87 0.39 4.61e-11 Colonoscopy-negative controls vs population controls; CESC cis rs55728055 0.661 rs62237772 chr22:31964975 A/C cg01338084 chr22:32026380 PISD 1.29 8.76 0.47 2.44e-16 Age-related hearing impairment; CESC cis rs681343 1.000 rs516316 chr19:49206145 C/G cg21064579 chr19:49206444 FUT2 0.52 7.45 0.42 1.3e-12 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CESC cis rs9929218 0.954 rs2059254 chr16:68817439 C/T cg02972257 chr16:68554789 NA 0.45 5.5 0.32 9.12e-8 Colorectal cancer; CESC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.95 10.43 0.54 1.45e-21 Mean platelet volume; CESC cis rs4683142 0.518 rs4682811 chr3:46164795 A/G cg18004856 chr3:46029278 FYCO1 0.42 5.05 0.3 8.18e-7 Methadone dose in opioid dependence; CESC cis rs3008870 1.000 rs3008853 chr1:67385488 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.06 14.96 0.68 4.41e-37 Lymphocyte percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00177013 chr20:62339100 ARFRP1;ZGPAT -0.43 -6.41 -0.37 6.82e-10 Gambling; CESC cis rs6540556 0.723 rs6540551 chr1:209925295 C/T cg05527609 chr1:210001259 C1orf107 -0.47 -5.73 -0.33 2.7e-8 Red blood cell count; CESC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg27170947 chr2:26402098 FAM59B 0.81 8.91 0.48 8.12e-17 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg10691866 chr7:65817282 TPST1 0.31 5.24 0.31 3.34e-7 Aortic root size; CESC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg23281280 chr6:28129359 ZNF389 0.49 6.54 0.37 3.24e-10 Parkinson's disease; CESC cis rs561341 1.000 rs564714 chr17:30318404 C/T cg19193384 chr17:30244184 NA -0.71 -6.61 -0.38 2.14e-10 Hip circumference adjusted for BMI; CESC cis rs7408868 1.000 rs7254735 chr19:15263385 A/G cg14696996 chr19:15285081 NOTCH3 1.0 10.51 0.54 7.9e-22 Pulse pressure; CESC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg27170947 chr2:26402098 FAM59B -0.87 -10.16 -0.53 1.05e-20 Gut microbiome composition (summer); CESC cis rs3820068 0.603 rs35509554 chr1:15993514 C/T cg13390004 chr1:15929781 NA 0.33 5.24 0.31 3.36e-7 Systolic blood pressure; CESC cis rs7264396 0.790 rs2425083 chr20:34300456 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.69 -0.58 9.64e-26 Total cholesterol levels; CESC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg07677032 chr17:61819896 STRADA 0.44 5.84 0.34 1.5e-8 Prudent dietary pattern; CESC cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg27347728 chr4:17578864 LAP3 0.49 5.56 0.32 6.68e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1153858 1.000 rs11852800 chr15:45639131 A/G cg10760299 chr15:45669010 GATM -0.39 -5.17 -0.3 4.55e-7 Homoarginine levels; CESC cis rs7824557 0.767 rs28507159 chr8:11166076 C/T cg21775007 chr8:11205619 TDH 0.5 7.27 0.41 4e-12 Retinal vascular caliber; CESC cis rs12477438 0.798 rs6542849 chr2:99578493 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.22 -0.53 6.79e-21 Chronic sinus infection; CESC cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.91e-28 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00894870 chr1:19578612 MRTO4;KIAA0090 0.5 6.48 0.37 4.47e-10 Gut microbiota (bacterial taxa); CESC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg05535760 chr7:792225 HEATR2 -0.78 -8.24 -0.45 8.16e-15 Cerebrospinal P-tau181p levels; CESC cis rs7084402 0.967 rs1658463 chr10:60298208 C/T cg07615347 chr10:60278583 BICC1 0.6 9.46 0.5 1.77e-18 Refractive error; CESC trans rs28549925 0.590 rs28376061 chr7:16990425 G/A cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.83e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg04944784 chr2:26401820 FAM59B -0.65 -7.35 -0.41 2.42e-12 Gut microbiome composition (summer); CESC cis rs9291683 0.530 rs10939620 chr4:9946132 C/T cg11266682 chr4:10021025 SLC2A9 -0.59 -11.76 -0.59 5.89e-26 Bone mineral density; CESC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg14893161 chr1:205819251 PM20D1 0.5 7.37 0.41 2.16e-12 Menarche (age at onset); CESC cis rs6088580 0.609 rs6058029 chr20:32969643 T/C cg06115741 chr20:33292138 TP53INP2 -0.46 -5.96 -0.34 7.8e-9 Glomerular filtration rate (creatinine); CESC cis rs6430585 0.528 rs115553816 chr2:136692893 G/A cg07169764 chr2:136633963 MCM6 1.26 17.43 0.73 7.33e-46 Corneal structure; CESC cis rs2625529 0.617 rs13858 chr15:72433144 C/T cg16672083 chr15:72433130 SENP8 -0.33 -5.15 -0.3 5.12e-7 Red blood cell count; CESC trans rs1977584 0.725 rs17507956 chr10:45401394 C/T cg09262100 chr14:103416268 CDC42BPB 0.61 6.14 0.35 3.02e-9 Selective IgA deficiency; CESC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg18099408 chr3:52552593 STAB1 -0.32 -5.36 -0.31 1.78e-7 Bipolar disorder; CESC cis rs864537 0.676 rs1773561 chr1:167421951 C/T cg22356347 chr1:167427500 CD247 -0.39 -8.05 -0.44 2.81e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg11663144 chr21:46675770 NA -0.49 -7.42 -0.41 1.57e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg18769074 chr3:133464867 TF 0.31 5.58 0.32 5.89e-8 Iron status biomarkers; CESC cis rs9815354 1.000 rs6802340 chr3:41894034 T/C cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.48e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg05564831 chr3:52568323 NT5DC2 0.42 6.14 0.35 3.04e-9 Bipolar disorder; CESC cis rs752010 0.695 rs10890155 chr1:42107843 C/T cg06885757 chr1:42089581 HIVEP3 0.49 7.87 0.44 9.35e-14 Lupus nephritis in systemic lupus erythematosus; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22766368 chr14:105119774 NA -0.41 -6.11 -0.35 3.55e-9 Gut microbiota (bacterial taxa); CESC cis rs13095912 0.752 rs9758141 chr3:185315085 A/T cg11274856 chr3:185301563 NA 0.4 6.07 0.35 4.38e-9 Systolic blood pressure; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg19972591 chr12:120966863 COQ5 -0.47 -6.05 -0.35 4.97e-9 Recombination measurement; CESC cis rs1707322 0.893 rs9919275 chr1:46441360 A/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12410462 1.000 rs76233861 chr1:227673909 G/A cg23173402 chr1:227635558 NA 0.58 5.64 0.33 4.34e-8 Major depressive disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11726039 chr2:208490019 FAM119A -0.5 -6.56 -0.37 2.83e-10 Fibrinogen levels; CESC cis rs863345 0.604 rs2051450 chr1:158464062 A/G cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs6430585 0.527 rs62168833 chr2:136449254 G/A cg07169764 chr2:136633963 MCM6 1.09 12.56 0.61 1.07e-28 Corneal structure; CESC cis rs965469 0.947 rs6051692 chr20:3244098 T/C cg25506879 chr20:3388711 C20orf194 -0.61 -6.45 -0.37 5.27e-10 IFN-related cytopenia; CESC cis rs2235642 0.928 rs9932984 chr16:1605051 A/G cg03771183 chr16:1608904 IFT140 0.42 6.16 0.35 2.62e-9 Coronary artery disease; CESC cis rs7264396 0.690 rs2425170 chr20:34442672 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -11.53 -0.58 3.36e-25 Total cholesterol levels; CESC cis rs763121 0.853 rs6519119 chr22:38989007 C/G cg14440974 chr22:39074834 NA -0.4 -5.29 -0.31 2.61e-7 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26602477 chr1:1476845 C1orf70 -0.45 -6.04 -0.35 5.09e-9 Gut microbiota (bacterial taxa); CESC cis rs11997175 0.653 rs4268089 chr8:33626532 G/A ch.8.33884649F chr8:33765107 NA 0.54 6.78 0.38 7.65e-11 Body mass index; CESC cis rs4268898 0.552 rs4665663 chr2:24372139 G/C cg20701182 chr2:24300061 SF3B14 -0.39 -5.32 -0.31 2.23e-7 Asthma; CESC cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.79 8.15 0.45 1.43e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08028037 chr13:52027479 INTS6 0.56 6.97 0.39 2.58e-11 Gut microbiome composition (summer); CESC cis rs1707322 1.000 rs785493 chr1:46584859 A/G cg03146154 chr1:46216737 IPP -0.74 -9.64 -0.51 4.75e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg24209194 chr3:40518798 ZNF619 0.47 6.07 0.35 4.32e-9 Renal cell carcinoma; CESC cis rs17433780 0.612 rs7911 chr1:89518120 A/G cg09516651 chr1:89888402 LOC400759 0.59 8.86 0.48 1.19e-16 Carotid intima media thickness; CESC cis rs6840258 1.000 rs10516788 chr4:87960857 A/G cg08197287 chr4:87952173 AFF1 -0.39 -5.28 -0.31 2.65e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs1008375 1.000 rs7688682 chr4:17693794 A/G cg16339924 chr4:17578868 LAP3 -0.59 -7.29 -0.41 3.49e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg22535103 chr8:58192502 C8orf71 -1.07 -13.52 -0.64 5.05e-32 Developmental language disorder (linguistic errors); CESC cis rs1185460 0.967 rs1786684 chr11:118938435 G/A cg01677386 chr11:118938358 VPS11 -0.44 -5.68 -0.33 3.61e-8 Coronary artery disease; CESC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg21782813 chr7:2030301 MAD1L1 0.41 5.61 0.33 5.17e-8 Bipolar disorder and schizophrenia; CESC cis rs6060717 0.536 rs17432470 chr20:34547763 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -6.66 -0.38 1.58e-10 Hip circumference adjusted for BMI; CESC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg26441486 chr22:50317300 CRELD2 0.43 5.16 0.3 4.75e-7 Schizophrenia; CESC cis rs9948 0.786 rs62156225 chr2:97414118 T/C cg01990225 chr2:97406019 LMAN2L -0.96 -7.6 -0.42 5.16e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 8.01 0.44 3.7e-14 Electroencephalogram traits; CESC cis rs113835537 0.569 rs17496586 chr11:66315512 G/C cg24851651 chr11:66362959 CCS 0.55 6.39 0.37 7.32e-10 Airway imaging phenotypes; CESC cis rs10876993 0.890 rs812304 chr12:58074853 A/C cg18357645 chr12:58087776 OS9 0.65 10.63 0.55 3.37e-22 Celiac disease or Rheumatoid arthritis; CESC cis rs6426558 0.502 rs2813970 chr1:227410637 C/T cg10327440 chr1:227177885 CDC42BPA 0.49 6.21 0.36 2.01e-9 Neutrophil percentage of white cells; CESC cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.88 -9.14 -0.49 1.72e-17 Schizophrenia; CESC cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg26408565 chr15:76604113 ETFA -0.43 -6.25 -0.36 1.65e-9 Blood metabolite levels; CESC cis rs3820068 0.544 rs7551750 chr1:16035008 T/C cg13390004 chr1:15929781 NA 0.33 5.13 0.3 5.64e-7 Systolic blood pressure; CESC cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg04450456 chr4:17643702 FAM184B 0.38 5.35 0.31 1.87e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10206020 0.842 rs7590900 chr2:1574902 A/G cg12573674 chr2:1569213 NA -0.46 -5.2 -0.3 3.96e-7 IgG glycosylation; CESC cis rs2370759 1.000 rs2769241 chr10:32556229 T/C cg18270830 chr10:32634957 EPC1 -0.72 -6.61 -0.38 2.06e-10 Sexual dysfunction (female); CESC cis rs2486288 0.656 rs12908581 chr15:45548635 C/T cg21132104 chr15:45694354 SPATA5L1 -0.44 -5.28 -0.31 2.74e-7 Glomerular filtration rate; CESC cis rs4764487 0.760 rs4764486 chr12:6327989 A/G cg08284733 chr12:6341482 CD9 0.4 6.08 0.35 4.14e-9 Mean platelet volume; CESC cis rs11112613 0.713 rs2374502 chr12:105938939 T/C cg03607813 chr12:105948248 NA 0.66 8.07 0.44 2.54e-14 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20683454 chr8:124412914 NA -0.43 -6.06 -0.35 4.63e-9 Gut microbiome composition (summer); CESC cis rs8114671 0.935 rs633198 chr20:33778434 T/C cg24642439 chr20:33292090 TP53INP2 -0.42 -5.04 -0.3 8.77e-7 Height; CESC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg11764359 chr7:65958608 NA -0.8 -11.89 -0.59 2.01e-26 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14469191 chr9:68380472 NA -0.45 -6.06 -0.35 4.56e-9 Gut microbiome composition (summer); CESC cis rs9457247 0.967 rs86755 chr6:167403108 T/C cg25258033 chr6:167368657 RNASET2 0.4 5.98 0.34 7.15e-9 Crohn's disease; CESC trans rs743002 0.554 rs113784934 chr22:41377326 G/A cg21776993 chr19:1449424 APC2 -0.66 -6.22 -0.36 1.93e-9 Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells;Eosinophil counts; CESC cis rs9487051 0.714 rs1546722 chr6:109625797 A/G cg12927641 chr6:109611667 NA -0.36 -5.26 -0.31 3e-7 Reticulocyte fraction of red cells; CESC cis rs10751667 1.000 rs4074232 chr11:977682 C/G cg20946044 chr11:1010712 AP2A2 -0.44 -5.91 -0.34 1.07e-8 Alzheimer's disease (late onset); CESC cis rs10823500 0.748 rs2394668 chr10:71943951 G/A cg02100629 chr10:71892760 AIFM2 -0.34 -5.24 -0.31 3.33e-7 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10757027 chr7:150783788 AGAP3 0.52 6.36 0.36 8.6e-10 Gut microbiome composition (summer); CESC cis rs9303401 0.703 rs9911583 chr17:57210721 A/G cg12560992 chr17:57184187 TRIM37 -0.44 -5.23 -0.31 3.39e-7 Cognitive test performance; CESC cis rs72781680 0.611 rs72781696 chr2:24267014 C/T cg20701182 chr2:24300061 SF3B14 0.94 10.66 0.55 2.67e-22 Lymphocyte counts; CESC cis rs1942 1.000 rs1942 chr15:41774423 A/G cg18705301 chr15:41695430 NDUFAF1 -0.53 -7.42 -0.41 1.58e-12 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC trans rs35110281 0.627 rs7282704 chr21:44966253 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 7.55 0.42 7.17e-13 Mean corpuscular volume; CESC cis rs1163251 0.902 rs639761 chr1:120217558 G/A cg19096424 chr1:120255104 PHGDH 0.43 5.22 0.31 3.62e-7 Blood metabolite levels; CESC cis rs7927592 0.913 rs10896338 chr11:68299360 G/A cg20283391 chr11:68216788 NA -0.62 -7.44 -0.42 1.42e-12 Total body bone mineral density; CESC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg09359103 chr1:154839909 KCNN3 -0.65 -12.33 -0.6 6.58e-28 Prostate cancer; CESC cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg14416269 chr4:6271139 WFS1 0.47 7.89 0.44 7.84e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 7.34 0.41 2.57e-12 Melanoma; CESC cis rs12497850 0.644 rs11928552 chr3:48739883 T/C cg06212747 chr3:49208901 KLHDC8B 0.59 7.44 0.42 1.43e-12 Parkinson's disease; CESC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.69 0.33 3.39e-8 Bipolar disorder; CESC cis rs3820068 0.532 rs6701009 chr1:15935614 T/C cg13390004 chr1:15929781 NA 0.36 5.81 0.34 1.8e-8 Systolic blood pressure; CESC cis rs9815354 0.812 rs17214987 chr3:41810481 C/T cg03022575 chr3:42003672 ULK4 -0.66 -6.17 -0.35 2.56e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6460942 0.915 rs62448620 chr7:12458170 C/T cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg07648498 chr16:89883185 FANCA 0.43 5.35 0.31 1.91e-7 Vitiligo; CESC cis rs2976388 0.578 rs4736324 chr8:143830462 G/A cg20862496 chr8:143823734 SLURP1 0.35 5.37 0.31 1.71e-7 Urinary tract infection frequency; CESC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg21238619 chr17:78079768 GAA 0.37 5.23 0.31 3.5e-7 Yeast infection; CESC cis rs6465657 0.903 rs11767962 chr7:97778576 C/T cg24562669 chr7:97807699 LMTK2 0.82 13.45 0.64 8.74e-32 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs1023500 0.505 rs134889 chr22:42674350 A/T cg15557168 chr22:42548783 NA -0.45 -7.03 -0.4 1.78e-11 Schizophrenia; CESC cis rs17376456 0.569 rs6556839 chr5:93206292 T/C cg21475434 chr5:93447410 FAM172A -0.52 -5.25 -0.31 3.13e-7 Diabetic retinopathy; CESC cis rs34375054 0.526 rs117431213 chr12:125675271 C/G cg00522288 chr12:125625016 AACS -0.34 -5.28 -0.31 2.69e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg02375832 chr11:62437615 C11orf48 -0.36 -5.08 -0.3 7.14e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.22 0.45 9.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg18876405 chr7:65276391 NA -0.62 -8.27 -0.45 6.72e-15 Aortic root size; CESC cis rs116095464 0.558 rs73031482 chr5:227594 G/A cg22496380 chr5:211416 CCDC127 -0.72 -8.45 -0.46 1.92e-15 Breast cancer; CESC cis rs6502050 1.000 rs6502050 chr17:80058236 C/G cg01763666 chr17:80159506 CCDC57 0.37 5.11 0.3 6.21e-7 Life satisfaction; CESC cis rs11792861 0.926 rs1051474 chr9:111881856 T/C cg05043794 chr9:111880884 C9orf5 -0.41 -6.74 -0.38 9.84e-11 Menarche (age at onset); CESC cis rs2742234 0.910 rs2505511 chr10:43641029 T/A cg15436174 chr10:43711423 RASGEF1A -0.41 -5.25 -0.31 3.18e-7 Hirschsprung disease; CESC cis rs7633770 0.786 rs1520488 chr3:46677459 C/T cg11219411 chr3:46661640 NA 0.33 5.29 0.31 2.51e-7 Coronary artery disease; CESC cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.4 -6.51 -0.37 3.73e-10 Hemoglobin concentration; CESC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg18876405 chr7:65276391 NA -0.54 -7.03 -0.4 1.73e-11 Aortic root size; CESC cis rs425277 1.000 rs74877653 chr1:2065949 C/T cg16545954 chr1:2118288 C1orf86 0.33 5.56 0.32 6.55e-8 Height; CESC cis rs35110281 0.641 rs4818861 chr21:45123807 A/G cg21573476 chr21:45109991 RRP1B -0.58 -7.94 -0.44 5.78e-14 Mean corpuscular volume; CESC cis rs8072100 0.713 rs3871595 chr17:45511388 C/T cg08085267 chr17:45401833 C17orf57 -0.52 -6.6 -0.38 2.28e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs1814175 0.935 rs7950947 chr11:49668369 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -17.79 -0.74 4.04e-47 Height; CESC cis rs7044106 0.791 rs10985000 chr9:123484115 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 13.03 0.63 2.43e-30 Hip circumference adjusted for BMI; CESC cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.19 0.3 4.29e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg23978390 chr7:1156363 C7orf50 0.43 5.53 0.32 7.87e-8 Longevity;Endometriosis; CESC cis rs9487051 0.768 rs386696 chr6:109520166 G/A cg01475377 chr6:109611718 NA -0.45 -6.86 -0.39 4.74e-11 Reticulocyte fraction of red cells; CESC cis rs13064447 0.753 rs9868500 chr3:12747690 A/G cg23032965 chr3:12705835 RAF1 0.41 5.25 0.31 3.09e-7 Major depression and alcohol dependence; CESC cis rs12530845 1.000 rs60179239 chr7:135333028 A/G cg23117316 chr7:135346802 PL-5283 -0.41 -5.24 -0.31 3.35e-7 Red blood cell traits; CESC cis rs1707322 0.964 rs785496 chr1:46588006 T/C cg03146154 chr1:46216737 IPP -0.74 -9.64 -0.51 4.75e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg24578937 chr1:2090814 PRKCZ -0.38 -6.71 -0.38 1.15e-10 Height; CESC cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg06634786 chr22:41940651 POLR3H 0.63 6.33 0.36 1.05e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg25036284 chr2:26402008 FAM59B 0.86 9.4 0.5 2.74e-18 Gut microbiome composition (summer); CESC trans rs1814175 0.616 rs4881723 chr11:49788566 G/T cg11707556 chr5:10655725 ANKRD33B -0.42 -6.06 -0.35 4.69e-9 Height; CESC cis rs3768617 0.966 rs10911253 chr1:183086190 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 8.88 0.48 1.03e-16 Fuchs's corneal dystrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19916409 chr4:103266691 SLC39A8 0.63 7.52 0.42 8.32e-13 Gut microbiome composition (summer); CESC cis rs6541297 0.703 rs2748117 chr1:230320156 C/T cg20703242 chr1:230279135 GALNT2 -0.41 -5.36 -0.31 1.84e-7 Coronary artery disease; CESC cis rs7267979 1.000 rs6115146 chr20:25304507 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.41 -0.75 2.54e-49 Liver enzyme levels (alkaline phosphatase); CESC cis rs854765 0.693 rs8080061 chr17:17776389 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.75 -0.38 9.18e-11 Total body bone mineral density; CESC trans rs1829883 0.600 rs2461966 chr5:98733594 A/G cg23861655 chr4:57411219 NA 0.4 6.49 0.37 4.16e-10 Hemostatic factors and hematological phenotypes; CESC cis rs854765 0.547 rs6502632 chr17:17913057 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.53 7.01 0.4 2.02e-11 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17391929 chr14:24702094 GMPR2;NEDD8 -0.63 -7.15 -0.4 8.59e-12 Gut microbiome composition (summer); CESC cis rs4253772 0.550 rs6008762 chr22:46736228 T/C cg09491104 chr22:46646882 C22orf40 -0.55 -6.48 -0.37 4.46e-10 LDL cholesterol;Cholesterol, total; CESC cis rs9858542 0.953 rs11713474 chr3:49611457 A/G cg07274523 chr3:49395745 GPX1 0.65 8.3 0.45 5.23e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg21970626 chr13:21893289 NA -0.42 -6.09 -0.35 3.85e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs17253792 0.822 rs112308750 chr14:56080073 G/A cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21250466 chr4:854474 GAK 0.46 6.56 0.37 2.73e-10 Fibrinogen levels; CESC cis rs7208859 0.623 rs55961983 chr17:29119286 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs965469 1.000 rs6051747 chr20:3307945 T/C cg25506879 chr20:3388711 C20orf194 -0.57 -6.15 -0.35 2.79e-9 IFN-related cytopenia; CESC cis rs17376456 1.000 rs58734583 chr5:93532155 C/T cg21475434 chr5:93447410 FAM172A 0.87 7.83 0.43 1.18e-13 Diabetic retinopathy; CESC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg17376030 chr22:41985996 PMM1 -0.79 -8.37 -0.46 3.43e-15 Vitiligo; CESC cis rs55728055 0.661 rs62237849 chr22:32029807 T/C cg01338084 chr22:32026380 PISD 1.26 8.23 0.45 8.62e-15 Age-related hearing impairment; CESC cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs12477438 1.000 rs73963398 chr2:99887025 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -8.1 -0.45 2e-14 Chronic sinus infection; CESC cis rs27434 0.615 rs61112531 chr5:96191820 G/A cg16492584 chr5:96139282 ERAP1 0.52 6.19 0.36 2.23e-9 Ankylosing spondylitis; CESC cis rs6541297 1.000 rs6686680 chr1:230280522 T/C cg20703242 chr1:230279135 GALNT2 0.73 11.12 0.56 8.07e-24 Coronary artery disease; CESC cis rs933688 1.000 rs9293568 chr5:90737845 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 13.79 0.65 5.53e-33 Smoking behavior; CESC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg07648498 chr16:89883185 FANCA -0.44 -5.44 -0.32 1.19e-7 Vitiligo; CESC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg05332525 chr7:65337924 VKORC1L1 0.51 6.38 0.36 7.81e-10 Aortic root size; CESC cis rs6466055 0.720 rs6466057 chr7:104952483 A/G cg04380332 chr7:105027541 SRPK2 0.4 5.42 0.32 1.32e-7 Schizophrenia; CESC cis rs11583043 0.958 rs11583674 chr1:101396560 C/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.55 6.34 0.36 9.81e-10 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs367943 0.712 rs7734304 chr5:112730165 G/A cg12552261 chr5:112820674 MCC 0.39 5.26 0.31 2.99e-7 Type 2 diabetes; CESC cis rs7959452 0.503 rs7300266 chr12:69654187 A/G cg20891283 chr12:69753455 YEATS4 0.75 11.21 0.57 3.97e-24 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15383980 chr1:113741483 NA 0.52 6.67 0.38 1.52e-10 Fibrinogen levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20853569 chr17:79247697 SLC38A10 0.46 6.01 0.35 6.19e-9 Fibrinogen levels; CESC cis rs2228479 0.850 rs2238525 chr16:89809902 T/C cg14709524 chr16:89940631 TCF25 0.75 6.48 0.37 4.39e-10 Skin colour saturation; CESC cis rs2732480 0.523 rs34286639 chr12:48629044 C/T cg24011408 chr12:48396354 COL2A1 0.43 5.9 0.34 1.11e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs116095464 0.558 rs6874745 chr5:264527 A/G cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.51e-10 Breast cancer; CESC cis rs8114671 0.836 rs6060165 chr20:33619480 A/C cg07148914 chr20:33460835 GGT7 -0.41 -5.33 -0.31 2.13e-7 Height; CESC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg18876405 chr7:65276391 NA 0.56 7.57 0.42 6.22e-13 Aortic root size; CESC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg12516959 chr21:47718080 NA -0.41 -5.93 -0.34 9.51e-9 Testicular germ cell tumor; CESC cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg14983838 chr19:29218262 NA 0.44 5.95 0.34 8.33e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs9900062 0.586 rs2676307 chr17:62690713 C/G cg02097616 chr17:62675921 NA 0.43 5.17 0.3 4.58e-7 QT interval; CESC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg19723775 chr5:179050963 HNRNPH1 -0.44 -5.84 -0.34 1.51e-8 Lung cancer; CESC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg11965913 chr1:205819406 PM20D1 0.81 13.76 0.65 7.16e-33 Menarche (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22798821 chr11:11864085 USP47 0.55 7.08 0.4 1.27e-11 Gut microbiota (bacterial taxa); CESC cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg05457628 chr5:178986728 RUFY1 0.45 6.11 0.35 3.46e-9 Lung cancer; CESC cis rs751837 0.518 rs74085588 chr14:103456702 C/T cg10087771 chr14:103399429 CDC42BPB 0.61 5.41 0.32 1.4e-7 Large B-cell lymphoma; CESC cis rs6831352 0.918 rs29001209 chr4:100052340 C/A cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs68170813 0.559 rs7794965 chr7:106826439 A/G cg02696742 chr7:106810147 HBP1 0.56 5.41 0.32 1.41e-7 Coronary artery disease; CESC cis rs11214589 0.905 rs2186799 chr11:113242533 G/T cg14159747 chr11:113255604 NA 0.33 5.84 0.34 1.53e-8 Neuroticism; CESC cis rs7017914 0.934 rs13255152 chr8:71859619 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.16 -0.3 4.74e-7 Bone mineral density; CESC cis rs556990 0.760 rs3024739 chr13:113819948 G/A cg00898013 chr13:113819073 PROZ -0.52 -6.72 -0.38 1.08e-10 Blood protein levels; CESC trans rs10838801 1 rs10838801 chr11:48098280 G/A cg03929089 chr4:120376271 NA -0.62 -7.7 -0.43 2.7e-13 Height; CESC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Depression; CESC cis rs1348850 1.000 rs3927978 chr2:178443854 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.64 -8.99 -0.48 4.81e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs11098499 0.863 rs6858592 chr4:120458692 G/A cg09307838 chr4:120376055 NA 0.88 11.94 0.59 1.39e-26 Corneal astigmatism; CESC cis rs11871801 1.000 rs35272895 chr17:40580669 T/A cg21433558 chr17:40837037 CNTNAP1 0.45 5.04 0.3 8.46e-7 Crohn's disease; CESC cis rs17407555 0.821 rs4473652 chr4:10141617 G/C cg11266682 chr4:10021025 SLC2A9 -0.49 -5.18 -0.3 4.33e-7 Schizophrenia (age at onset); CESC cis rs34779708 0.931 rs4007289 chr10:35269790 G/A cg04310649 chr10:35416472 CREM -0.52 -6.35 -0.36 9.54e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs59918340 0.764 rs3824234 chr8:142229370 T/C cg16341495 chr8:142228727 SLC45A4 -0.44 -5.34 -0.31 1.98e-7 Immature fraction of reticulocytes; CESC cis rs17376456 0.569 rs7729807 chr5:93104089 C/T cg21475434 chr5:93447410 FAM172A 0.49 5.03 0.3 9.16e-7 Diabetic retinopathy; CESC cis rs250677 0.687 rs2915809 chr5:148452111 A/T cg18129178 chr5:148520854 ABLIM3 -0.5 -5.77 -0.33 2.22e-8 Breast cancer; CESC cis rs3820068 0.705 rs11577225 chr1:15864242 T/C cg17385448 chr1:15911702 AGMAT 0.37 5.91 0.34 1.03e-8 Systolic blood pressure; CESC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.605 rs35158616 chr17:80094480 A/G cg01763666 chr17:80159506 CCDC57 -0.37 -5.05 -0.3 8.22e-7 Life satisfaction; CESC cis rs6570726 0.935 rs369214 chr6:145856709 G/A cg05347473 chr6:146136440 FBXO30 0.48 6.44 0.37 5.7e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03352830 chr11:487213 PTDSS2 0.74 7.5 0.42 9.59e-13 Body mass index; CESC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg09323728 chr8:95962352 TP53INP1 -0.42 -9.45 -0.5 1.83e-18 Type 2 diabetes; CESC cis rs8114671 0.869 rs2145559 chr20:33651725 G/A cg24642439 chr20:33292090 TP53INP2 -0.49 -5.88 -0.34 1.23e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21235025 chr13:72249355 DACH1 -0.52 -6.19 -0.36 2.29e-9 Gut microbiome composition (summer); CESC cis rs113835537 0.935 rs1127145 chr11:66373305 G/A cg22134325 chr11:66188745 NPAS4 0.5 5.76 0.33 2.27e-8 Airway imaging phenotypes; CESC cis rs9914988 0.943 rs4313850 chr17:27080768 T/C cg20469991 chr17:27169893 C17orf63 -0.47 -5.09 -0.3 6.85e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg12463550 chr7:65579703 CRCP -0.49 -6.3 -0.36 1.21e-9 Aortic root size; CESC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg13607699 chr17:42295918 UBTF 0.56 7.21 0.41 5.79e-12 Total body bone mineral density; CESC cis rs9399135 0.935 rs11760000 chr6:135370496 G/A cg22676075 chr6:135203613 NA 0.52 7.31 0.41 3.17e-12 Red blood cell count; CESC cis rs78456975 1.000 rs11903168 chr2:1560497 C/G cg01028140 chr2:1542097 TPO -0.5 -5.37 -0.31 1.69e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs9916302 0.706 rs4332770 chr17:37704712 T/C cg00129232 chr17:37814104 STARD3 -0.55 -5.69 -0.33 3.39e-8 Glomerular filtration rate (creatinine); CESC cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg08508325 chr11:3079039 CARS 0.51 9.28 0.5 6.49e-18 Longevity; CESC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg21784768 chr11:537496 LRRC56 -0.54 -5.08 -0.3 7.13e-7 Body mass index; CESC cis rs17376456 0.569 rs1349711 chr5:93179032 C/T cg21475434 chr5:93447410 FAM172A -0.5 -5.14 -0.3 5.44e-7 Diabetic retinopathy; CESC cis rs7605827 0.930 rs3828465 chr2:15535497 A/T cg19274914 chr2:15703543 NA 0.35 6.22 0.36 1.98e-9 Educational attainment (years of education); CESC cis rs2880765 0.743 rs12906308 chr15:86008059 C/T cg10818794 chr15:86012489 AKAP13 0.33 5.12 0.3 6.02e-7 Coronary artery disease; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg08138407 chr1:35582349 NA 0.43 6.12 0.35 3.42e-9 Thyroid stimulating hormone; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10297430 chr16:11272440 CLEC16A 0.49 6.29 0.36 1.33e-9 Fibrinogen levels; CESC cis rs4974559 0.793 rs10025954 chr4:1351382 C/T cg02980000 chr4:1222292 CTBP1 0.71 6.68 0.38 1.38e-10 Systolic blood pressure; CESC cis rs7674212 0.510 rs55715738 chr4:104130189 A/G cg16532752 chr4:104119610 CENPE -0.38 -5.21 -0.3 3.8e-7 Type 2 diabetes; CESC cis rs4654899 0.627 rs667071 chr1:21045726 T/C cg05370193 chr1:21551575 ECE1 0.35 5.03 0.3 9.1e-7 Superior frontal gyrus grey matter volume; CESC cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg05234568 chr11:5960015 NA -0.63 -7.53 -0.42 8.12e-13 DNA methylation (variation); CESC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg27121462 chr16:89883253 FANCA 0.75 10.77 0.55 1.1e-22 Vitiligo; CESC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.98 0.34 7.35e-9 Tonsillectomy; CESC cis rs17253792 0.822 rs17683614 chr14:56041058 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.73 0.33 2.76e-8 Putamen volume; CESC cis rs796364 0.806 rs34381014 chr2:200916403 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.85 -7.93 -0.44 6.07e-14 Schizophrenia; CESC cis rs473651 0.837 rs563458 chr2:239345613 T/A cg21699342 chr2:239360505 ASB1 0.55 9.45 0.5 1.85e-18 Multiple system atrophy; CESC trans rs79976124 0.719 rs34488909 chr6:66637850 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.69 7.91 0.44 6.93e-14 Type 2 diabetes; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04513197 chr1:100504319 HIAT1 0.46 6.22 0.36 1.95e-9 Systemic lupus erythematosus; CESC cis rs3733585 0.673 rs6849729 chr4:9958732 T/C cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1568889 0.838 rs12273631 chr11:28042135 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.82 13.89 0.65 2.49e-33 Bipolar disorder; CESC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg06873352 chr17:61820015 STRADA -0.69 -11.28 -0.57 2.38e-24 Prudent dietary pattern; CESC cis rs1865721 0.771 rs4622605 chr18:73139008 T/C cg26385618 chr18:73139727 C18orf62 -0.49 -8.0 -0.44 3.82e-14 Intelligence; CESC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg04315214 chr1:2043799 PRKCZ 0.47 7.56 0.42 6.63e-13 Height; CESC cis rs9303280 0.651 rs59716545 chr17:38031857 T/G cg20243544 chr17:37824526 PNMT 0.53 6.86 0.39 4.8e-11 Self-reported allergy; CESC cis rs3740713 0.920 rs112818034 chr11:18455180 T/C cg23797887 chr11:18477753 LDHAL6A -0.53 -5.11 -0.3 6.1e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9303401 0.614 rs28651036 chr17:57080471 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 10.75 0.55 1.32e-22 Cognitive test performance; CESC cis rs6545883 0.894 rs12622458 chr2:61523554 A/C cg15711740 chr2:61764176 XPO1 0.4 5.13 0.3 5.74e-7 Tuberculosis; CESC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg18876405 chr7:65276391 NA 0.49 5.91 0.34 1.05e-8 Aortic root size; CESC cis rs8017423 0.647 rs12883357 chr14:90815032 A/G cg14092571 chr14:90743983 NA 0.5 7.62 0.42 4.61e-13 Mortality in heart failure; CESC cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg22875332 chr1:76189707 ACADM 0.66 7.83 0.43 1.15e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2742417 0.603 rs2673062 chr3:45763635 A/G cg04837898 chr3:45731254 SACM1L -0.47 -6.21 -0.36 2.08e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg03351412 chr1:154909251 PMVK 0.66 8.96 0.48 5.83e-17 Prostate cancer; CESC cis rs7680126 0.597 rs78917351 chr4:10208063 A/C cg11266682 chr4:10021025 SLC2A9 -0.44 -5.72 -0.33 2.88e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg07507251 chr3:52567010 NT5DC2 0.42 7.2 0.4 6.23e-12 Bipolar disorder; CESC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3749237 0.595 rs885592 chr3:49497883 T/G cg03060546 chr3:49711283 APEH 0.77 11.84 0.59 2.98e-26 Resting heart rate; CESC cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg05340658 chr4:99064831 C4orf37 0.75 10.76 0.55 1.26e-22 Colonoscopy-negative controls vs population controls; CESC cis rs12681288 0.823 rs2701903 chr8:1004029 A/G cg04851639 chr8:1020857 NA 0.33 7.3 0.41 3.46e-12 Schizophrenia; CESC trans rs561341 1.000 rs2470267 chr17:30274132 G/A cg20587970 chr11:113659929 NA -1.14 -14.26 -0.66 1.22e-34 Hip circumference adjusted for BMI; CESC cis rs864537 0.646 rs1723016 chr1:167433056 T/C cg09179987 chr1:167433047 CD247 0.53 8.2 0.45 1.07e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs4561483 0.549 rs154149 chr16:11956118 T/A cg08843971 chr16:11963173 GSPT1 -0.52 -7.32 -0.41 3e-12 Testicular germ cell tumor; CESC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg22920501 chr2:26401640 FAM59B -0.86 -10.06 -0.53 2.22e-20 Gut microbiome composition (summer); CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg25998860 chr5:126853954 PRRC1 0.45 6.03 0.35 5.53e-9 Weight; CESC cis rs2243480 1.000 rs35820085 chr7:65442758 C/T cg25894440 chr7:65020034 NA -0.68 -5.88 -0.34 1.23e-8 Diabetic kidney disease; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg00941241 chr1:9885960 CLSTN1 -0.48 -6.37 -0.36 8.54e-10 Subjective well-being; CESC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg23161317 chr6:28129485 ZNF389 0.51 6.63 0.38 1.85e-10 Depression; CESC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg07507251 chr3:52567010 NT5DC2 0.35 5.54 0.32 7.43e-8 Bipolar disorder; CESC cis rs3809566 0.963 rs4775608 chr15:63331940 A/G cg05507819 chr15:63340323 TPM1 0.52 6.37 0.36 8.15e-10 Platelet count; CESC cis rs12476592 0.543 rs262539 chr2:63908270 G/A cg17519650 chr2:63277830 OTX1 0.46 5.04 0.3 8.79e-7 Childhood ear infection; CESC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg08027265 chr7:2291960 NA -0.33 -5.08 -0.3 7.15e-7 Bipolar disorder and schizophrenia; CESC cis rs1256061 0.603 rs1256037 chr14:64743301 G/A cg23250157 chr14:64679961 SYNE2 0.53 7.63 0.42 4.14e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.06e-7 Aortic root size; CESC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg08859206 chr1:53392774 SCP2 -0.68 -9.49 -0.5 1.38e-18 Monocyte count; CESC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg21770322 chr7:97807741 LMTK2 0.57 8.73 0.47 2.84e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs35110281 0.807 rs1598206 chr21:45058776 A/G cg21573476 chr21:45109991 RRP1B -0.46 -6.42 -0.37 6.38e-10 Mean corpuscular volume; CESC cis rs4481887 0.927 rs4534422 chr1:248479482 A/G cg00666640 chr1:248458726 OR2T12 0.35 5.67 0.33 3.82e-8 Common traits (Other); CESC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg06481639 chr22:41940642 POLR3H -0.63 -6.57 -0.37 2.63e-10 Vitiligo; CESC cis rs6088580 0.634 rs13041646 chr20:33082881 T/A cg06115741 chr20:33292138 TP53INP2 0.45 5.74 0.33 2.62e-8 Glomerular filtration rate (creatinine); CESC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg19163074 chr7:65112434 INTS4L2 -0.41 -5.09 -0.3 6.96e-7 Aortic root size; CESC cis rs929354 0.772 rs6459739 chr7:156998863 A/T cg05182265 chr7:156933206 UBE3C -0.51 -7.47 -0.42 1.2e-12 Body mass index; CESC cis rs7927771 0.507 rs1483988 chr11:47899030 C/T cg18512352 chr11:47633146 NA 0.38 5.87 0.34 1.28e-8 Subjective well-being; CESC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg24675658 chr1:53192096 ZYG11B -0.54 -6.7 -0.38 1.25e-10 Monocyte count; CESC cis rs7178572 0.524 rs2175941 chr15:77584498 T/C cg22256960 chr15:77711686 NA -0.53 -6.6 -0.38 2.26e-10 Type 2 diabetes; CESC trans rs11098499 0.866 rs12501602 chr4:120287935 A/T cg25214090 chr10:38739885 LOC399744 0.66 9.2 0.49 1.13e-17 Corneal astigmatism; CESC cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg22875332 chr1:76189707 ACADM 0.71 9.86 0.52 9.97e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg19912559 chr1:40204330 PPIE 0.42 6.48 0.37 4.37e-10 Blood protein levels; CESC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg17372223 chr3:52568218 NT5DC2 0.38 5.33 0.31 2.09e-7 Bipolar disorder; CESC cis rs3617 0.625 rs2535633 chr3:52859630 C/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.36 -5.09 -0.3 6.71e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11064206 chr12:123459532 OGFOD2;ABCB9 -0.42 -6.15 -0.35 2.81e-9 Gambling; CESC cis rs1044826 0.692 rs188420 chr3:139233865 G/A cg00490450 chr3:139108681 COPB2 -0.44 -5.45 -0.32 1.13e-7 Obesity-related traits; CESC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.33 0.31 2.11e-7 Tonsillectomy; CESC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg23978390 chr7:1156363 C7orf50 0.53 7.1 0.4 1.16e-11 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14380045 chr9:15527817 NA -0.59 -6.96 -0.39 2.59e-11 Gut microbiome composition (summer); CESC cis rs34779708 0.966 rs4934737 chr10:35512799 T/C cg03585969 chr10:35415529 CREM 0.75 9.46 0.5 1.78e-18 Inflammatory bowel disease;Crohn's disease; CESC cis rs7129220 0.512 rs57618276 chr11:10129276 C/T cg01453529 chr11:10209919 SBF2 -0.47 -5.37 -0.31 1.7e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7814319 0.700 rs871798 chr8:97257982 T/C cg20787634 chr8:97240163 UQCRB -0.53 -6.37 -0.36 8.41e-10 Lung function (FVC); CESC cis rs10865397 0.506 rs60764301 chr2:73384850 G/A cg01422370 chr2:73384389 NA 0.46 7.27 0.41 4.11e-12 Intelligence (multi-trait analysis); CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg12857786 chr4:83934023 LIN54 0.55 6.17 0.35 2.51e-9 Endometrial cancer; CESC cis rs6736093 0.966 rs3811634 chr2:112754943 C/T cg12686935 chr2:112915763 FBLN7 -0.42 -5.51 -0.32 8.34e-8 Coronary artery disease; CESC cis rs7208859 0.623 rs9898084 chr17:29082334 C/G cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2204008 0.807 rs11182461 chr12:38539288 T/C cg13010199 chr12:38710504 ALG10B 0.53 6.86 0.39 4.74e-11 Bladder cancer; CESC cis rs1949733 0.628 rs2688231 chr4:8490981 G/A cg11789530 chr4:8429930 ACOX3 0.72 10.15 0.53 1.18e-20 Response to antineoplastic agents; CESC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg18099408 chr3:52552593 STAB1 0.36 6.62 0.38 2e-10 Electroencephalogram traits; CESC cis rs6088580 0.634 rs4142007 chr20:32990050 G/T cg06115741 chr20:33292138 TP53INP2 -0.47 -6.14 -0.35 3.06e-9 Glomerular filtration rate (creatinine); CESC cis rs7647973 0.961 rs6778080 chr3:49317338 C/T cg07636037 chr3:49044803 WDR6 -0.58 -8.28 -0.45 6.15e-15 Menarche (age at onset); CESC cis rs123509 0.687 rs73075297 chr3:42832466 A/G cg12982090 chr3:42733453 KBTBD5 -0.66 -7.52 -0.42 8.26e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1538970 0.816 rs868351 chr1:46009818 G/T cg03146154 chr1:46216737 IPP 0.45 5.34 0.31 2e-7 Platelet count; CESC cis rs12142240 0.698 rs72677599 chr1:46834251 G/A cg00530320 chr1:46809349 NSUN4 0.6 8.11 0.45 1.85e-14 Menopause (age at onset); CESC cis rs9916302 0.851 rs677888 chr17:37461018 T/G cg07936489 chr17:37558343 FBXL20 0.72 9.28 0.5 6.35e-18 Glomerular filtration rate (creatinine); CESC cis rs9399401 0.667 rs17071756 chr6:142715195 C/T cg03128060 chr6:142623767 GPR126 -0.37 -6.33 -0.36 1.06e-9 Chronic obstructive pulmonary disease; CESC cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg26373071 chr5:1325741 CLPTM1L 0.44 7.08 0.4 1.31e-11 Lung cancer; CESC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs9325144 0.560 rs11183046 chr12:38655270 A/T cg26384229 chr12:38710491 ALG10B -0.6 -8.49 -0.46 1.45e-15 Morning vs. evening chronotype; CESC cis rs713587 0.563 rs10865315 chr2:25100738 C/A cg01884057 chr2:25150051 NA 0.33 6.17 0.35 2.49e-9 Body mass index in non-asthmatics; CESC cis rs9300255 0.620 rs1716173 chr12:123660721 A/T cg19016782 chr12:123741754 C12orf65 -0.45 -6.21 -0.36 2.01e-9 Neutrophil percentage of white cells; CESC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg13206674 chr6:150067644 NUP43 0.42 5.82 0.34 1.66e-8 Lung cancer; CESC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg27297192 chr10:134578999 INPP5A 0.42 5.48 0.32 9.68e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2625529 0.590 rs12904652 chr15:72548765 T/C cg16672083 chr15:72433130 SENP8 -0.39 -5.45 -0.32 1.16e-7 Red blood cell count; CESC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg05863683 chr7:1912471 MAD1L1 0.51 7.79 0.43 1.49e-13 Bipolar disorder and schizophrenia; CESC cis rs637571 0.726 rs689274 chr11:65665988 A/G cg26695010 chr11:65641043 EFEMP2 0.5 6.43 0.37 5.84e-10 Eosinophil percentage of white cells; CESC cis rs7542091 0.669 rs11119357 chr1:210042382 C/T cg22029157 chr1:209979665 IRF6 0.49 7.58 0.42 5.74e-13 Monobrow; CESC cis rs6681460 0.966 rs10889643 chr1:67143368 G/C cg02459107 chr1:67143332 SGIP1 0.38 5.47 0.32 1.03e-7 Presence of antiphospholipid antibodies; CESC cis rs329122 0.528 rs11242219 chr5:133848760 A/G cg26284174 chr5:133860141 NA 0.45 5.13 0.3 5.62e-7 Body mass index;Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14475554 chr1:209799191 LAMB3 -0.57 -6.6 -0.38 2.21e-10 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24641125 chr21:40721130 HMGN1 -0.46 -6.02 -0.35 5.67e-9 Asthma; CESC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg27535305 chr1:53392650 SCP2 -0.33 -5.47 -0.32 1.06e-7 Monocyte count; CESC cis rs7116495 0.609 rs2155142 chr11:71642524 A/G cg26138937 chr11:71823887 C11orf51 1.18 8.24 0.45 8.18e-15 Severe influenza A (H1N1) infection; CESC cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.07 0.3 7.65e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg20243544 chr17:37824526 PNMT -0.46 -5.86 -0.34 1.37e-8 Glomerular filtration rate (creatinine); CESC cis rs6499755 0.712 rs31091 chr16:55363818 T/C cg02859129 chr16:55357253 IRX6 0.32 5.05 0.3 8.04e-7 Hypospadias; CESC cis rs12971120 0.891 rs4891558 chr18:72170359 A/G cg25817165 chr18:72167213 CNDP2 -0.58 -6.78 -0.38 7.61e-11 Refractive error; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15168842 chr8:144766844 ZNF707 0.57 6.34 0.36 1.01e-9 Gut microbiome composition (summer); CESC cis rs3762318 1.000 rs12090164 chr1:67600163 G/A cg17031739 chr1:67600172 NA 0.52 5.54 0.32 7.2e-8 Leprosy; CESC cis rs17253792 0.822 rs79291233 chr14:56065302 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.62 0.33 4.81e-8 Putamen volume; CESC cis rs4835473 0.900 rs10003922 chr4:144842388 C/T cg25736465 chr4:144833511 NA -0.46 -7.12 -0.4 1.02e-11 Immature fraction of reticulocytes; CESC cis rs3733585 0.578 rs6837224 chr4:9955255 G/T cg00071950 chr4:10020882 SLC2A9 -0.69 -11.31 -0.57 1.83e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs17376456 0.877 rs10050465 chr5:93349963 C/A cg25358565 chr5:93447407 FAM172A 1.1 10.7 0.55 1.98e-22 Diabetic retinopathy; CESC cis rs6582630 0.537 rs1829579 chr12:38420555 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.1 0.35 3.7e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7402982 0.625 rs12905392 chr15:99199212 G/A cg03437748 chr15:99193247 IGF1R 0.66 8.6 0.47 7.04e-16 Birth weight; CESC cis rs7100689 0.577 rs2236569 chr10:82043576 G/A cg00277334 chr10:82204260 NA -0.52 -6.86 -0.39 4.86e-11 Post bronchodilator FEV1; CESC cis rs10838687 0.736 rs3781620 chr11:47259264 G/C cg25783544 chr11:47291846 MADD 0.57 6.52 0.37 3.55e-10 Proinsulin levels; CESC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg27170947 chr2:26402098 FAM59B -0.57 -6.75 -0.38 9.43e-11 Gut microbiome composition (summer); CESC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg02951883 chr7:2050386 MAD1L1 -0.42 -5.68 -0.33 3.58e-8 Bipolar disorder and schizophrenia; CESC cis rs2370759 1.000 rs11594459 chr10:32561858 A/C cg01819863 chr10:32635814 EPC1 1.16 12.08 0.6 4.67e-27 Sexual dysfunction (female); CESC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg09060608 chr5:178986726 RUFY1 0.54 8.48 0.46 1.59e-15 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18046087 chr11:66035276 KLC2;RAB1B -0.67 -7.84 -0.43 1.12e-13 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs55643307 chr17:30263074 T/C cg00745463 chr17:30367425 LRRC37B -0.83 -7.43 -0.42 1.49e-12 Hip circumference adjusted for BMI; CESC cis rs4563143 0.592 rs12151001 chr19:29283386 C/G cg12756686 chr19:29218302 NA 0.55 6.67 0.38 1.51e-10 Methadone dose in opioid dependence; CESC cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg17541715 chr7:1216824 NA -0.38 -5.16 -0.3 4.91e-7 Longevity;Endometriosis; CESC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg06713675 chr4:122721982 EXOSC9 -0.51 -7.01 -0.4 1.94e-11 Type 2 diabetes; CESC cis rs933688 0.941 rs6452954 chr5:90735692 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.12 15.37 0.69 1.48e-38 Smoking behavior; CESC cis rs854765 0.583 rs4553680 chr17:17857722 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.55 7.47 0.42 1.16e-12 Total body bone mineral density; CESC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg21782813 chr7:2030301 MAD1L1 -0.43 -6.15 -0.35 2.89e-9 Bipolar disorder and schizophrenia; CESC trans rs11098499 0.909 rs10017335 chr4:120381523 C/G cg25214090 chr10:38739885 LOC399744 -0.66 -9.15 -0.49 1.61e-17 Corneal astigmatism; CESC cis rs72945132 0.882 rs72945168 chr11:70131471 G/C cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC cis rs10416265 0.527 rs7246814 chr19:33538414 G/T cg03563238 chr19:33554763 RHPN2 -0.31 -5.58 -0.32 5.97e-8 Bone properties (heel); CESC cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg24308560 chr3:49941425 MST1R 0.6 8.72 0.47 3.17e-16 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17888837 chr1:27986674 NA 0.56 6.43 0.37 6.06e-10 Gut microbiome composition (summer); CESC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 10.92 0.56 3.59e-23 Platelet count; CESC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.0 0.8 9.67e-62 Prudent dietary pattern; CESC cis rs4253772 0.530 rs11704350 chr22:46671507 C/T cg24881330 chr22:46731750 TRMU 0.78 5.86 0.34 1.34e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.86 0.34 1.37e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs17376456 0.825 rs13164315 chr5:93147421 A/G cg21475434 chr5:93447410 FAM172A 0.83 7.35 0.41 2.41e-12 Diabetic retinopathy; CESC cis rs9399137 0.507 rs35571217 chr6:135290355 T/C cg24558204 chr6:135376177 HBS1L 0.7 9.64 0.51 4.87e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02056921 chr1:901892 PLEKHN1 -0.44 -6.24 -0.36 1.68e-9 Gambling; CESC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg18016565 chr1:150552671 MCL1 0.33 5.13 0.3 5.67e-7 Tonsillectomy; CESC cis rs7312933 0.703 rs1059360 chr12:42554505 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.47 6.13 0.35 3.23e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs921968 0.643 rs484085 chr2:219396684 C/T cg02176678 chr2:219576539 TTLL4 0.42 7.44 0.42 1.43e-12 Mean corpuscular hemoglobin concentration; CESC cis rs8038465 0.874 rs12591553 chr15:73993755 G/A cg15420318 chr15:73925796 NPTN 0.41 5.83 0.34 1.57e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs970548 0.697 rs11239540 chr10:45999209 T/C cg16175941 chr6:154779103 CNKSR3 0.59 6.46 0.37 4.95e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CESC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs2230307 0.536 rs482466 chr1:100488177 C/T cg24955406 chr1:100503596 HIAT1 0.53 5.35 0.31 1.91e-7 Carotid intima media thickness; CESC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg05896524 chr21:47604654 C21orf56 0.42 5.39 0.31 1.58e-7 Testicular germ cell tumor; CESC trans rs561341 1.000 rs8077092 chr17:30281992 T/C cg27661571 chr11:113659931 NA -0.7 -7.19 -0.4 6.82e-12 Hip circumference adjusted for BMI; CESC cis rs7072216 0.763 rs10748729 chr10:100171371 G/C cg26618903 chr10:100175079 PYROXD2 -0.38 -5.78 -0.33 2.05e-8 Metabolite levels; CESC cis rs7089973 0.584 rs7908665 chr10:116611337 G/A cg25233709 chr10:116636983 FAM160B1 0.4 6.63 0.38 1.93e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7714584 1.000 rs12054923 chr5:150249059 A/G cg22134413 chr5:150180641 NA 0.51 5.64 0.33 4.46e-8 Crohn's disease; CESC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg13206674 chr6:150067644 NUP43 0.43 6.23 0.36 1.82e-9 Lung cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13456812 chr6:167369504 RNASET2 0.46 6.3 0.36 1.22e-9 Systemic lupus erythematosus; CESC cis rs2243480 1.000 rs781150 chr7:65480973 C/T cg12463550 chr7:65579703 CRCP 0.69 5.5 0.32 9.17e-8 Diabetic kidney disease; CESC trans rs6460942 0.556 rs10228123 chr7:12374025 A/C cg16269144 chr1:2003326 PRKCZ 0.5 6.16 0.35 2.73e-9 Coronary artery disease; CESC trans rs877282 0.838 rs34912955 chr10:772222 T/C cg22713356 chr15:30763199 NA 1.26 12.75 0.62 2.39e-29 Uric acid levels; CESC trans rs61931739 0.500 rs34418276 chr12:34535976 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.54 0.54 6.28e-22 Morning vs. evening chronotype; CESC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs9487051 0.714 rs6927569 chr6:109621494 T/C cg01475377 chr6:109611718 NA -0.43 -6.64 -0.38 1.74e-10 Reticulocyte fraction of red cells; CESC cis rs921968 0.541 rs667251 chr2:219384384 C/G cg02176678 chr2:219576539 TTLL4 0.5 9.09 0.49 2.31e-17 Mean corpuscular hemoglobin concentration; CESC cis rs733175 0.855 rs9291640 chr4:10007086 C/T cg00071950 chr4:10020882 SLC2A9 0.54 6.53 0.37 3.27e-10 Psychosis and Alzheimer's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02099313 chr1:231114956 TTC13;ARV1 -0.43 -6.24 -0.36 1.74e-9 Gambling; CESC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg05368731 chr17:41323189 NBR1 0.78 10.53 0.54 6.98e-22 Menopause (age at onset); CESC cis rs4843747 0.671 rs28451517 chr16:88109127 A/C cg06915872 chr16:87998081 BANP 0.45 5.32 0.31 2.26e-7 Menopause (age at onset); CESC trans rs11098499 0.697 rs28458294 chr4:120238924 T/C cg25214090 chr10:38739885 LOC399744 0.59 8.11 0.45 1.85e-14 Corneal astigmatism; CESC cis rs55788414 0.932 rs35066366 chr16:81185280 G/A cg06400318 chr16:81190750 PKD1L2 -0.6 -6.82 -0.39 6.19e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs425277 1.000 rs262654 chr1:2089526 G/A cg24578937 chr1:2090814 PRKCZ 0.53 8.99 0.48 4.93e-17 Height; CESC trans rs11165623 0.715 rs1980769 chr1:96888201 A/T cg10631902 chr5:14652156 NA -0.55 -8.35 -0.46 3.81e-15 Hip circumference;Waist circumference; CESC cis rs4808199 0.895 rs4808194 chr19:19435680 T/G cg03709012 chr19:19516395 GATAD2A 1.08 12.07 0.6 5.22e-27 Nonalcoholic fatty liver disease; CESC cis rs72781680 1.000 rs72781675 chr2:24232092 G/A cg08917208 chr2:24149416 ATAD2B 1.06 9.33 0.5 4.33e-18 Lymphocyte counts; CESC cis rs734999 0.588 rs4648562 chr1:2535613 C/A cg18854424 chr1:2615690 NA 0.27 5.24 0.31 3.32e-7 Ulcerative colitis; CESC cis rs6691722 0.503 rs7546875 chr1:24703667 T/C cg18323236 chr1:24743029 NIPAL3 0.36 5.38 0.31 1.63e-7 Response to interferon beta in multiple sclerosis; CESC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg11941060 chr3:133502564 NA -0.47 -6.32 -0.36 1.13e-9 Iron status biomarkers; CESC cis rs7666738 0.830 rs62318471 chr4:98925848 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.23 0.45 8.65e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.541 rs62052173 chr16:89950739 T/C cg04013166 chr16:89971882 TCF25 0.72 8.82 0.48 1.58e-16 Skin colour saturation; CESC cis rs9611565 0.765 rs132915 chr22:41805782 T/C cg06634786 chr22:41940651 POLR3H 0.71 7.47 0.42 1.16e-12 Vitiligo; CESC cis rs4704187 0.624 rs35719345 chr5:74551962 T/C cg03227963 chr5:74354835 NA 0.29 5.34 0.31 2.04e-7 Response to amphetamines; CESC trans rs7618501 0.602 rs2526754 chr3:50125996 G/A cg21659725 chr3:3221576 CRBN -0.51 -7.04 -0.4 1.66e-11 Intelligence (multi-trait analysis); CESC cis rs5769765 0.955 rs2319465 chr22:50265784 A/C cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs10129255 0.500 rs988134 chr14:107184937 A/G cg23076370 chr14:107095027 NA -0.66 -9.85 -0.52 1.01e-19 Kawasaki disease; CESC cis rs1003719 0.788 rs9975168 chr21:38450557 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.67 -0.47 4.29e-16 Eye color traits; CESC cis rs11638352 0.661 rs2114415 chr15:44432894 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.56 -5.29 -0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs8033133 0.678 rs7496110 chr15:25347013 A/G cg14481604 chr15:25334117 SNORD116-22 -0.35 -5.46 -0.32 1.12e-7 Blood osmolality (transformed sodium); CESC trans rs7089973 0.523 rs11197017 chr10:116737738 C/A cg17463145 chr7:79084011 MAGI2 0.31 6.15 0.35 2.89e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9818941 0.824 rs12632906 chr3:157726384 T/A cg08654915 chr3:157813417 NA -0.45 -7.55 -0.42 6.85e-13 Height; CESC cis rs8114671 0.586 rs734111 chr20:33533736 A/C cg07148914 chr20:33460835 GGT7 0.52 6.8 0.39 6.92e-11 Height; CESC cis rs3820068 0.822 rs2901964 chr1:15792426 C/G cg18192808 chr1:15853278 DNAJC16 0.48 5.73 0.33 2.65e-8 Systolic blood pressure; CESC cis rs4076764 0.846 rs12035840 chr1:163419177 G/C cg24596788 chr1:163392923 NA -0.41 -5.84 -0.34 1.51e-8 Motion sickness; CESC cis rs8180040 0.934 rs62260710 chr3:47564462 C/G cg27129171 chr3:47204927 SETD2 -0.61 -8.52 -0.46 1.23e-15 Colorectal cancer; CESC cis rs8005677 0.828 rs8016027 chr14:23420153 T/C cg01529538 chr14:23388837 RBM23 0.44 5.83 0.34 1.64e-8 Cognitive ability (multi-trait analysis); CESC cis rs10170846 0.626 rs9288575 chr2:223495133 A/C cg25565276 chr2:223520875 FARSB 1.09 14.97 0.68 3.99e-37 Schizophrenia (inflammation and infection response interaction); CESC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg13206674 chr6:150067644 NUP43 0.41 5.67 0.33 3.77e-8 Lung cancer; CESC cis rs67478160 0.643 rs2887282 chr14:104280734 A/G cg08213375 chr14:104286397 PPP1R13B 0.48 9.11 0.49 2.02e-17 Schizophrenia; CESC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg10295955 chr4:187884368 NA -1.08 -23.01 -0.82 4.07e-65 Lobe attachment (rater-scored or self-reported); CESC cis rs1048238 0.846 rs945419 chr1:16344858 C/T cg21214613 chr1:16344536 HSPB7 0.34 5.61 0.33 5.06e-8 Systolic blood pressure; CESC cis rs524023 0.914 rs11231845 chr11:64407419 G/A cg07220939 chr11:64358617 SLC22A12 -0.35 -5.33 -0.31 2.14e-7 Urate levels in obese individuals; CESC cis rs1729951 0.575 rs16844325 chr3:136678161 C/G cg25687071 chr3:136751404 NA 0.39 5.07 0.3 7.55e-7 Neuroticism; CESC cis rs7259376 0.936 rs7259586 chr19:22537862 C/T cg02657401 chr19:22469223 NA -0.25 -5.23 -0.31 3.38e-7 Menopause (age at onset); CESC cis rs1580019 0.587 rs7806113 chr7:32553084 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.52 6.69 0.38 1.33e-10 Cognitive ability; CESC trans rs1728785 1.000 rs1624718 chr16:68580385 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs7927771 1.000 rs4752873 chr11:47857520 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -6.04 -0.35 5.24e-9 Subjective well-being; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13888710 chr4:39699558 UBE2K -0.47 -6.12 -0.35 3.28e-9 Fibrinogen levels; CESC cis rs2066819 1.000 rs75598973 chr12:56746558 C/T cg26734620 chr12:56694298 CS 0.97 5.81 0.34 1.76e-8 Psoriasis vulgaris; CESC cis rs2777491 0.574 rs11858812 chr15:41731550 G/A cg20272979 chr15:41787780 ITPKA 0.43 5.31 0.31 2.37e-7 Ulcerative colitis; CESC cis rs8103278 0.740 rs72626215 chr19:46294136 G/A cg12641515 chr19:46296257 DMWD -0.57 -5.74 -0.33 2.65e-8 Coronary artery disease; CESC cis rs2243480 1.000 rs10807702 chr7:65767843 C/T cg18252515 chr7:66147081 NA -1.27 -11.84 -0.59 3.11e-26 Diabetic kidney disease; CESC cis rs758324 0.617 rs12719447 chr5:131118100 C/A cg06307176 chr5:131281290 NA 0.43 5.16 0.3 4.9e-7 Alzheimer's disease in APOE e4- carriers; CESC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.5 -0.37 3.97e-10 Parkinson's disease; CESC cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg18769074 chr3:133464867 TF 0.32 6.1 0.35 3.64e-9 Iron status biomarkers (transferrin levels); CESC cis rs6942756 0.840 rs963465 chr7:128875612 C/G cg02491457 chr7:128862824 NA 0.64 9.54 0.51 1.02e-18 White matter hyperintensity burden; CESC cis rs6977660 0.652 rs10486362 chr7:19755224 A/G cg07541023 chr7:19748670 TWISTNB -0.83 -7.21 -0.41 5.77e-12 Thyroid stimulating hormone; CESC cis rs7208859 0.673 rs9891179 chr17:29208160 G/T cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9913156 0.707 rs11657052 chr17:4570573 C/T cg19197139 chr17:4613644 ARRB2 -0.84 -9.8 -0.52 1.55e-19 Lymphocyte counts; CESC cis rs4835473 0.932 rs4383567 chr4:144710026 G/A cg25736465 chr4:144833511 NA 0.31 5.03 0.3 8.84e-7 Immature fraction of reticulocytes; CESC cis rs698813 0.604 rs768006 chr2:44487612 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.6 0.33 5.26e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2050392 0.517 rs656600 chr10:30765654 G/A cg18806716 chr10:30721971 MAP3K8 -0.45 -6.81 -0.39 6.52e-11 Inflammatory bowel disease; CESC cis rs507506 0.771 rs929229 chr17:7105399 C/T cg25256661 chr17:7137939 DVL2 0.59 7.64 0.42 4.08e-13 Adiponectin levels; CESC cis rs9611565 0.592 rs28750375 chr22:41990644 A/C cg03806693 chr22:41940476 POLR3H -0.86 -10.18 -0.53 9.25e-21 Vitiligo; CESC cis rs3767633 0.925 rs4656335 chr1:161822078 A/G cg09175582 chr1:161736000 ATF6 0.8 6.06 0.35 4.57e-9 IgG glycosylation; CESC cis rs6578985 0.636 rs3213225 chr11:2156536 C/T cg25406011 chr11:1254421 MUC5B -0.33 -5.19 -0.3 4.25e-7 Femoral neck bone geometry and menarche (age at onset); CESC cis rs66887589 0.660 rs4833613 chr4:120150156 A/C cg09307838 chr4:120376055 NA -0.46 -6.02 -0.35 5.82e-9 Diastolic blood pressure; CESC cis rs7809950 1.000 rs2293658 chr7:107270567 C/T cg23024343 chr7:107201750 COG5 -0.51 -7.19 -0.4 6.65e-12 Coronary artery disease; CESC cis rs864537 0.676 rs2056626 chr1:167420425 T/G cg22356347 chr1:167427500 CD247 -0.39 -8.1 -0.45 1.97e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs72792276 1.000 rs13357283 chr5:127423114 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.65 5.91 0.34 1.07e-8 Red cell distribution width; CESC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg19592336 chr6:28129416 ZNF389 0.42 5.47 0.32 1.04e-7 Depression; CESC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg08859206 chr1:53392774 SCP2 -0.55 -7.19 -0.4 6.76e-12 Monocyte count; CESC cis rs12541635 0.677 rs7846149 chr8:107053417 T/C cg10147462 chr8:107024639 NA 0.48 7.18 0.4 6.92e-12 Age of smoking initiation; CESC cis rs559928 0.548 rs11231713 chr11:63931849 C/T cg18225595 chr11:63971243 STIP1 0.74 6.28 0.36 1.39e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs4662945 0.525 rs10174479 chr2:130296287 A/C cg05903289 chr2:130345205 NA -0.44 -7.02 -0.4 1.91e-11 Response to cytidine analogues (gemcitabine); CESC cis rs7762018 1.000 rs4716380 chr6:170090399 A/G cg05834625 chr6:170176447 C6orf70 0.62 7.44 0.42 1.36e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6032067 0.777 rs979641 chr20:43786336 C/T cg10761708 chr20:43804764 PI3 0.56 6.55 0.37 3.01e-10 Blood protein levels; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg02372393 chr17:45973417 SP2 0.52 6.65 0.38 1.63e-10 Attention deficit hyperactivity disorder; CESC cis rs7814319 0.840 rs10504961 chr8:97240129 C/T cg20787634 chr8:97240163 UQCRB -0.63 -8.2 -0.45 1.03e-14 Lung function (FVC); CESC cis rs344364 0.511 rs1657144 chr16:1963989 C/A cg03013636 chr16:1946785 NA 0.44 5.57 0.32 6.2e-8 Glomerular filtration rate in chronic kidney disease; CESC trans rs239339 0.959 rs75411 chr1:4425414 C/T cg06451177 chr17:79412583 BAHCC1 0.52 6.11 0.35 3.63e-9 Obesity-related traits; CESC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg09699651 chr6:150184138 LRP11 0.45 5.74 0.33 2.56e-8 Lung cancer; CESC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.64 0.33 4.28e-8 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24663683 chr5:39721720 NA 0.49 6.72 0.38 1.13e-10 Fibrinogen levels; CESC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg05552183 chr6:42928497 GNMT 0.78 12.08 0.6 4.61e-27 Alzheimer's disease in APOE e4+ carriers; CESC cis rs524281 0.861 rs580891 chr11:65954681 A/C cg14036092 chr11:66035641 RAB1B -0.5 -5.6 -0.33 5.34e-8 Electroencephalogram traits; CESC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.89e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2235544 0.588 rs662603 chr1:54467767 T/C cg25741118 chr1:54482237 LDLRAD1 0.24 5.77 0.33 2.2e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs26868 0.766 rs27556 chr16:2249325 T/C cg02248941 chr16:2239361 CASKIN1 0.39 6.2 0.36 2.19e-9 Height; CESC cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg25554036 chr4:6271136 WFS1 0.49 7.55 0.42 7.23e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14290704 chr9:2015039 SMARCA2 -0.47 -6.45 -0.37 5.18e-10 Asthma; CESC cis rs250677 0.522 rs6580589 chr5:148360335 C/G cg18129178 chr5:148520854 ABLIM3 0.47 5.16 0.3 4.93e-7 Breast cancer; CESC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg14393609 chr7:65229607 NA -0.47 -6.31 -0.36 1.14e-9 Aortic root size; CESC cis rs9399401 0.601 rs262130 chr6:142853486 C/T cg03128060 chr6:142623767 GPR126 0.33 5.41 0.32 1.44e-7 Chronic obstructive pulmonary disease; CESC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg09658497 chr7:2847517 GNA12 -0.42 -5.91 -0.34 1.04e-8 Height; CESC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg17949981 chr6:28129498 ZNF389 0.45 5.52 0.32 8.18e-8 Depression; CESC cis rs6540556 0.768 rs6692012 chr1:209935490 A/G cg23920097 chr1:209922102 NA -0.37 -5.59 -0.32 5.64e-8 Red blood cell count; CESC cis rs2050392 0.630 rs303427 chr10:30739780 G/A cg18806716 chr10:30721971 MAP3K8 -0.43 -6.3 -0.36 1.2e-9 Inflammatory bowel disease; CESC trans rs4716602 0.596 rs10258969 chr7:156157753 A/G cg07175507 chr18:77160758 NFATC1 -0.45 -6.13 -0.35 3.13e-9 Anti-saccade response; CESC cis rs8114671 0.628 rs6060130 chr20:33549319 C/T cg24642439 chr20:33292090 TP53INP2 0.42 5.06 0.3 7.84e-7 Height; CESC cis rs7680126 0.632 rs11731464 chr4:10148376 G/A cg11266682 chr4:10021025 SLC2A9 -0.49 -5.99 -0.35 6.87e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg11041457 chr3:52719354 GNL3;PBRM1 0.53 8.02 0.44 3.41e-14 Bipolar disorder; CESC cis rs9549367 0.789 rs6577035 chr13:113879997 G/A cg00898013 chr13:113819073 PROZ -0.49 -6.87 -0.39 4.59e-11 Platelet distribution width; CESC cis rs72949976 0.934 rs1922794 chr2:214026181 G/A cg08319019 chr2:214017104 IKZF2 -0.47 -5.94 -0.34 9.11e-9 Lung cancer;Squamous cell lung carcinoma; CESC cis rs9486719 0.857 rs6568392 chr6:96861476 G/T cg06623918 chr6:96969491 KIAA0776 0.88 10.34 0.54 2.8e-21 Migraine;Coronary artery disease; CESC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg06634786 chr22:41940651 POLR3H -0.67 -6.45 -0.37 5.19e-10 Vitiligo; CESC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg06505273 chr16:24850292 NA 0.52 6.4 0.37 6.83e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs17490626 0.533 rs12771890 chr10:71189483 T/A cg12610070 chr10:71211762 TSPAN15 -0.35 -7.37 -0.41 2.24e-12 Thrombosis; CESC cis rs344364 0.511 rs1742463 chr16:1946110 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs11871801 1.000 rs34610643 chr17:40574388 A/C cg21433558 chr17:40837037 CNTNAP1 0.45 5.04 0.3 8.46e-7 Crohn's disease; CESC cis rs1801251 1.000 rs1022330 chr2:233577330 G/A cg25237894 chr2:233734115 C2orf82 0.48 8.11 0.45 1.86e-14 Coronary artery disease; CESC cis rs7178909 0.872 rs3867167 chr15:90433790 T/C cg19708238 chr15:90437601 AP3S2 0.37 5.12 0.3 5.94e-7 Common traits (Other); CESC cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs2857078 0.627 rs1476512 chr17:42330122 C/T cg08499158 chr17:42289980 UBTF 0.4 5.11 0.3 6.26e-7 Red cell distribution width;Reticulocyte count; CESC cis rs4803468 1.000 rs3810175 chr19:41904396 C/T cg09537434 chr19:41945824 ATP5SL 1.07 19.38 0.77 1.01e-52 Height; CESC cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg16240275 chr20:61666158 NCRNA00029 0.51 9.47 0.5 1.64e-18 Prostate cancer (SNP x SNP interaction); CESC cis rs854765 0.547 rs8069811 chr17:17922280 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.32 0.41 2.99e-12 Total body bone mineral density; CESC cis rs929354 0.742 rs6956046 chr7:156962874 G/A cg05182265 chr7:156933206 UBE3C -0.5 -7.3 -0.41 3.44e-12 Body mass index; CESC cis rs6831352 0.918 rs2602895 chr4:100045840 C/T cg12011299 chr4:100065546 ADH4 0.59 6.68 0.38 1.41e-10 Alcohol dependence; CESC cis rs8141529 0.748 rs5752826 chr22:29269808 A/G cg15103426 chr22:29168792 CCDC117 0.6 7.85 0.43 1.01e-13 Lymphocyte counts; CESC cis rs7212590 0.748 rs7211208 chr17:57957109 A/C cg20303301 chr17:57937339 TUBD1 -0.55 -5.5 -0.32 8.8e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs9354308 0.868 rs1938063 chr6:66559098 T/G cg07460842 chr6:66804631 NA -0.51 -6.18 -0.35 2.44e-9 Metabolite levels; CESC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg17372223 chr3:52568218 NT5DC2 0.42 6.49 0.37 4.27e-10 Bipolar disorder; CESC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg13628971 chr7:2884303 GNA12 -0.64 -9.05 -0.49 3.17e-17 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06821919 chr20:16710653 SNRPB2 0.57 6.65 0.38 1.67e-10 Gut microbiome composition (summer); CESC cis rs2836633 0.929 rs58120977 chr21:40037346 C/T cg05519781 chr21:40033154 ERG 0.78 13.52 0.64 5.12e-32 Coronary artery disease; CESC trans rs61931739 0.534 rs4001713 chr12:34154195 A/C cg26384229 chr12:38710491 ALG10B -0.64 -9.08 -0.49 2.6e-17 Morning vs. evening chronotype; CESC trans rs11874712 1.000 rs1800639 chr18:43671240 G/T cg00163037 chr11:43964802 LOC387763 -0.35 -5.99 -0.35 6.67e-9 Migraine - clinic-based; CESC cis rs4835473 0.900 rs34264936 chr4:144701447 A/G cg25736465 chr4:144833511 NA -0.42 -6.42 -0.37 6.21e-10 Immature fraction of reticulocytes; CESC cis rs911555 0.662 rs4906322 chr14:103879032 A/G cg24130564 chr14:104152367 KLC1 0.48 6.33 0.36 1.05e-9 Intelligence (multi-trait analysis); CESC cis rs7927592 0.763 rs4340059 chr11:68362433 A/G cg01657329 chr11:68192670 LRP5 -0.47 -6.13 -0.35 3.09e-9 Total body bone mineral density; CESC cis rs6424115 0.867 rs34902309 chr1:24192200 A/G cg15997130 chr1:24165203 NA -0.43 -5.78 -0.33 2.07e-8 Immature fraction of reticulocytes; CESC cis rs80282103 0.571 rs56183119 chr10:1068370 C/T cg08668510 chr10:1095578 IDI1 0.69 5.63 0.33 4.62e-8 Glomerular filtration rate (creatinine); CESC cis rs9611519 0.964 rs5995992 chr22:41487218 T/C cg03806693 chr22:41940476 POLR3H -0.55 -5.54 -0.32 7.36e-8 Neuroticism; CESC cis rs6920364 1 rs6920364 chr6:167376466 G/C cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.66e-7 Lung cancer; CESC cis rs561341 0.941 rs501773 chr17:30314435 T/G cg12193833 chr17:30244370 NA -0.57 -5.86 -0.34 1.37e-8 Hip circumference adjusted for BMI; CESC cis rs10865541 0.545 rs10176868 chr2:3383662 C/T cg11855769 chr2:3383351 TTC15 -0.45 -5.54 -0.32 7.47e-8 Obesity-related traits; CESC cis rs317689 0.690 rs7969559 chr12:69655167 A/G cg20891283 chr12:69753455 YEATS4 0.49 5.5 0.32 9.05e-8 Response to diuretic therapy; CESC cis rs13385 0.769 rs17118739 chr5:139597910 C/T cg26211634 chr5:139558579 C5orf32 0.47 5.19 0.3 4.12e-7 Atrial fibrillation; CESC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg03538708 chr1:25844672 NA 0.39 5.96 0.34 7.91e-9 Erythrocyte sedimentation rate; CESC cis rs17021463 0.872 rs11097417 chr4:95268071 C/T cg11021082 chr4:95130006 SMARCAD1 -0.51 -7.44 -0.42 1.39e-12 Testicular germ cell tumor; CESC cis rs55823223 0.648 rs936393 chr17:73847613 A/G cg23806715 chr17:73775811 H3F3B 0.61 6.79 0.38 7.55e-11 Psoriasis; CESC cis rs9549367 0.577 rs3024711 chr13:113813268 A/G cg18105134 chr13:113819100 PROZ -0.75 -8.64 -0.47 5.49e-16 Platelet distribution width; CESC cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg09455208 chr3:40491958 NA 0.42 6.94 0.39 3.09e-11 Renal cell carcinoma; CESC cis rs9910055 0.659 rs112114764 chr17:42201041 G/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.49 -7.35 -0.41 2.43e-12 Total body bone mineral density; CESC cis rs4849845 0.653 rs34874174 chr2:121011980 A/C cg24070213 chr2:121070622 NA 0.44 6.34 0.36 1.01e-9 Mean platelet volume; CESC cis rs4523957 0.928 rs7406247 chr17:2157925 G/A cg16513277 chr17:2031491 SMG6 0.6 8.29 0.45 5.67e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs3820068 0.603 rs10492986 chr1:15988702 T/C cg17385448 chr1:15911702 AGMAT 0.43 7.11 0.4 1.1e-11 Systolic blood pressure; CESC cis rs6991838 0.612 rs7842162 chr8:66556292 T/G cg13398993 chr8:66546079 ARMC1 0.49 5.97 0.34 7.6e-9 Intelligence (multi-trait analysis); CESC cis rs7116495 1.000 rs58991229 chr11:71839878 G/A cg10381502 chr11:71823885 C11orf51 0.65 5.23 0.31 3.43e-7 Severe influenza A (H1N1) infection; CESC cis rs9302635 0.513 rs8061459 chr16:72156063 C/T cg16558253 chr16:72132732 DHX38 -0.46 -6.04 -0.35 5.09e-9 Blood protein levels; CESC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg22823121 chr1:150693482 HORMAD1 -0.41 -5.67 -0.33 3.82e-8 Urate levels; CESC cis rs2730245 0.510 rs2788471 chr7:158649786 G/T cg15303052 chr7:158526867 ESYT2 -0.4 -5.09 -0.3 6.69e-7 Height; CESC cis rs6540559 0.673 rs7511996 chr1:210018473 C/A cg22029157 chr1:209979665 IRF6 0.66 7.44 0.42 1.4e-12 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17602823 chr1:28586543 SESN2 0.65 7.82 0.43 1.22e-13 Gut microbiome composition (summer); CESC cis rs4568518 0.616 rs11766586 chr7:18003965 T/C cg03009463 chr7:17980271 SNX13 0.43 5.72 0.33 2.91e-8 Measles; CESC cis rs2952156 0.920 rs2934953 chr17:37832315 T/A cg07936489 chr17:37558343 FBXL20 -0.55 -6.66 -0.38 1.55e-10 Asthma; CESC cis rs11098499 0.697 rs6832410 chr4:120296800 A/G cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg25204440 chr1:209979598 IRF6 0.65 6.68 0.38 1.42e-10 Cleft lip with or without cleft palate; CESC cis rs7131987 0.903 rs1035604 chr12:29393102 G/A cg09582351 chr12:29534625 ERGIC2 -0.33 -5.25 -0.31 3.13e-7 QT interval; CESC cis rs4704187 0.687 rs10050948 chr5:74484275 C/T cg03227963 chr5:74354835 NA 0.28 5.1 0.3 6.6e-7 Response to amphetamines; CESC cis rs9527 0.535 rs4917999 chr10:104963051 C/G cg04362960 chr10:104952993 NT5C2 -0.49 -6.04 -0.35 5.16e-9 Arsenic metabolism; CESC cis rs9039 1.000 rs9039 chr16:9205363 A/G cg08831531 chr16:9218945 NA -0.47 -6.44 -0.37 5.71e-10 Menopause (age at onset); CESC cis rs9399135 0.967 rs4388304 chr6:135309597 T/A cg24558204 chr6:135376177 HBS1L 0.5 6.72 0.38 1.11e-10 Red blood cell count; CESC trans rs6981523 0.566 rs34162231 chr8:11003088 A/T cg06636001 chr8:8085503 FLJ10661 -0.53 -6.4 -0.37 6.85e-10 Neuroticism; CESC cis rs10504229 0.679 rs12679920 chr8:58051710 G/T cg24829409 chr8:58192753 C8orf71 -0.5 -6.08 -0.35 4.07e-9 Developmental language disorder (linguistic errors); CESC trans rs9858542 0.953 rs6766581 chr3:49539401 T/C cg21659725 chr3:3221576 CRBN -0.55 -6.49 -0.37 4.22e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs1124376 0.935 rs28716666 chr3:20148409 C/T cg05072819 chr3:20081367 KAT2B 0.47 5.14 0.3 5.39e-7 Bipolar disorder and schizophrenia; CESC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg03517284 chr6:25882590 NA -0.58 -8.26 -0.45 6.88e-15 Blood metabolite levels; CESC cis rs11828289 0.607 rs76811253 chr11:23222885 G/A cg20040320 chr11:23191996 NA -0.68 -5.65 -0.33 4.04e-8 Cancer; CESC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs7267979 1.000 rs6050562 chr20:25336186 C/G cg08601574 chr20:25228251 PYGB -0.38 -5.49 -0.32 9.3e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg00612595 chr21:47717864 NA -0.41 -5.54 -0.32 7.17e-8 Testicular germ cell tumor; CESC cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg25019033 chr10:957182 NA -0.57 -5.58 -0.32 5.79e-8 Eosinophil percentage of granulocytes; CESC cis rs9814567 0.752 rs6764764 chr3:134331167 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 0.39 6.11 0.35 3.49e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24458846 chr11:66512593 C11orf80 -0.51 -6.45 -0.37 5.2e-10 Asthma; CESC cis rs950169 0.614 rs765524 chr15:84681782 G/T cg17507749 chr15:85114479 UBE2QP1 0.58 5.95 0.34 8.4e-9 Schizophrenia; CESC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg13393036 chr8:95962371 TP53INP1 -0.46 -9.56 -0.51 8.37e-19 Type 2 diabetes; CESC cis rs6066835 0.572 rs6125413 chr20:47257145 G/A cg18078177 chr20:47281410 PREX1 0.68 5.06 0.3 8.03e-7 Multiple myeloma; CESC trans rs1545843 0.565 rs7953925 chr12:84792044 A/C cg03015433 chr16:56623111 MT3 -0.34 -6.12 -0.35 3.37e-9 Major depressive disorder; CESC cis rs712039 0.652 rs866465 chr17:35859404 G/A cg16670864 chr17:35848621 DUSP14 0.48 5.96 0.34 8.07e-9 Tuberculosis; CESC cis rs1595825 0.891 rs79845692 chr2:198523541 T/C cg10820045 chr2:198174542 NA 0.41 5.21 0.3 3.79e-7 Ulcerative colitis; CESC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.73 9.85 0.52 1.03e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs708547 0.836 rs1625691 chr4:57845740 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.76 10.09 0.53 1.82e-20 Response to bleomycin (chromatid breaks); CESC cis rs9911578 1.000 rs1631237 chr17:56734695 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC cis rs10870270 1.000 rs7898755 chr10:133777122 G/A cg08754478 chr10:133766260 PPP2R2D -0.59 -7.57 -0.42 6.29e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7589342 0.929 rs1465640 chr2:106439103 C/T cg16077055 chr2:106428750 NCK2 0.49 6.98 0.39 2.38e-11 Addiction; CESC trans rs11098499 0.954 rs6849561 chr4:120409694 C/G cg25214090 chr10:38739885 LOC399744 -0.7 -9.73 -0.51 2.5e-19 Corneal astigmatism; CESC cis rs477692 0.544 rs12251589 chr10:131417354 C/A cg05714579 chr10:131428358 MGMT -0.73 -10.7 -0.55 1.88e-22 Response to temozolomide; CESC cis rs6570726 0.935 rs386344 chr6:145855622 A/G cg05347473 chr6:146136440 FBXO30 0.46 5.97 0.34 7.4e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg19077165 chr18:44547161 KATNAL2 0.54 8.01 0.44 3.56e-14 Personality dimensions; CESC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg25985355 chr7:65971099 NA -0.31 -5.15 -0.3 5.13e-7 Aortic root size; CESC cis rs9457247 0.905 rs377232 chr6:167409638 C/A cg23791538 chr6:167370224 RNASET2 -0.59 -8.44 -0.46 2.06e-15 Crohn's disease; CESC cis rs2439831 0.850 rs3097773 chr15:43893072 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.64 -8.25 -0.45 7.26e-15 Lung cancer in ever smokers; CESC cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg26516362 chr5:178986906 RUFY1 0.44 7.03 0.4 1.7e-11 Lung cancer; CESC cis rs4654899 1.000 rs7522722 chr1:21481840 G/A cg05370193 chr1:21551575 ECE1 0.41 6.24 0.36 1.72e-9 Superior frontal gyrus grey matter volume; CESC cis rs950169 0.920 rs2135551 chr15:84707851 A/G cg17507749 chr15:85114479 UBE2QP1 0.63 6.93 0.39 3.26e-11 Schizophrenia; CESC cis rs4268898 0.610 rs34216622 chr2:24463445 G/C cg06627628 chr2:24431161 ITSN2 -0.98 -11.11 -0.56 8.86e-24 Asthma; CESC cis rs1707322 0.686 rs3014235 chr1:46091512 A/G cg06784218 chr1:46089804 CCDC17 -0.4 -7.01 -0.4 1.97e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs3087243 0.755 rs231790 chr2:204700574 A/C cg01841312 chr10:38069945 NA -0.37 -6.38 -0.36 8.06e-10 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg24675658 chr1:53192096 ZYG11B -0.65 -8.42 -0.46 2.42e-15 Monocyte count; CESC cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg25405998 chr7:65216604 CCT6P1 0.44 5.17 0.3 4.58e-7 Aortic root size; CESC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg01448562 chr3:133502909 NA -0.43 -6.11 -0.35 3.5e-9 Iron status biomarkers; CESC cis rs854765 0.718 rs7224815 chr17:17845800 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.46 6.02 0.35 5.87e-9 Total body bone mineral density; CESC cis rs910316 0.789 rs4899552 chr14:75667921 C/A cg11812906 chr14:75593930 NEK9 -0.79 -12.06 -0.6 5.63e-27 Height; CESC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg03433033 chr1:76189801 ACADM -0.58 -5.97 -0.34 7.72e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7666738 0.830 rs13124904 chr4:98856973 T/C cg05340658 chr4:99064831 C4orf37 0.75 11.16 0.57 5.89e-24 Colonoscopy-negative controls vs population controls; CESC cis rs1046896 0.553 rs1044661 chr17:80901020 G/A cg19046167 chr17:80928561 B3GNTL1 0.54 6.56 0.37 2.78e-10 Glycated hemoglobin levels; CESC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg25566285 chr7:158114605 PTPRN2 0.49 8.13 0.45 1.64e-14 Calcium levels; CESC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg08888203 chr3:10149979 C3orf24 0.48 5.99 0.35 6.84e-9 Alzheimer's disease; CESC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg23758822 chr17:41437982 NA 1.01 15.35 0.69 1.81e-38 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00676969 chr14:74485475 ENTPD5;C14orf45 -0.56 -7.21 -0.4 5.8e-12 Ulcerative colitis; CESC cis rs13064411 0.696 rs35860985 chr3:113209828 C/T cg18753928 chr3:113234510 CCDC52 -0.52 -6.31 -0.36 1.17e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs977987 0.836 rs35209155 chr16:75470496 G/A cg03315344 chr16:75512273 CHST6 0.42 6.12 0.35 3.38e-9 Dupuytren's disease; CESC cis rs13082711 0.911 rs4973770 chr3:27425815 C/T cg02860705 chr3:27208620 NA 0.52 6.53 0.37 3.36e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs62229266 0.804 rs2835241 chr21:37411380 G/T cg12218747 chr21:37451666 NA 0.42 5.89 0.34 1.15e-8 Mitral valve prolapse; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11309342 chr7:1014982 COX19 0.56 6.46 0.37 4.92e-10 Gut microbiome composition (summer); CESC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg26939375 chr7:64535504 NA -0.64 -9.09 -0.49 2.32e-17 Calcium levels; CESC cis rs7178572 0.568 rs1602925 chr15:77685857 T/C cg22256960 chr15:77711686 NA -0.54 -6.95 -0.39 2.9e-11 Type 2 diabetes; CESC cis rs2952156 0.920 rs14050 chr17:37828072 C/T cg00129232 chr17:37814104 STARD3 -0.76 -10.36 -0.54 2.52e-21 Asthma; CESC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg07701084 chr6:150067640 NUP43 0.47 6.7 0.38 1.27e-10 Lung cancer; CESC trans rs5417 0.788 rs2654185 chr17:7183362 G/T cg15655154 chr3:113604241 GRAMD1C 0.49 6.66 0.38 1.61e-10 Diastolic blood pressure; CESC trans rs5756813 0.754 rs13057133 chr22:38179473 C/T cg19894588 chr14:64061835 NA -0.65 -8.14 -0.45 1.57e-14 Optic cup area;Vertical cup-disc ratio; CESC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg11941060 chr3:133502564 NA 0.43 5.82 0.34 1.7e-8 Iron status biomarkers; CESC cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg08917208 chr2:24149416 ATAD2B 0.62 5.93 0.34 9.57e-9 Lymphocyte counts; CESC cis rs1707322 0.682 rs12037459 chr1:46094959 T/G cg06784218 chr1:46089804 CCDC17 0.4 7.04 0.4 1.67e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7208859 0.623 rs9893422 chr17:29111715 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg11644478 chr21:40555479 PSMG1 0.58 7.75 0.43 2.03e-13 Cognitive function; CESC cis rs9640161 0.789 rs13223702 chr7:150058968 G/A cg10018233 chr7:150070692 REPIN1 0.38 5.42 0.32 1.35e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg09658497 chr7:2847517 GNA12 -0.44 -5.99 -0.35 6.65e-9 Height; CESC cis rs3126085 0.935 rs3126088 chr1:152305785 A/G cg03465714 chr1:152285911 FLG 0.43 5.22 0.31 3.62e-7 Atopic dermatitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05522848 chr5:68710359 RAD17;MARVELD2 -0.43 -6.11 -0.35 3.6e-9 Gut microbiota (bacterial taxa); CESC cis rs13223928 0.541 rs17132968 chr7:3136074 T/G cg19214707 chr7:3157722 NA -0.39 -5.34 -0.31 1.96e-7 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC trans rs8073060 0.586 rs225291 chr17:33927126 A/G cg19694781 chr19:47549865 TMEM160 -0.61 -6.88 -0.39 4.26e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.75 8.9 0.48 9.05e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs6060717 0.698 rs8123175 chr20:34609872 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -7.57 -0.42 6.33e-13 Hip circumference adjusted for BMI; CESC cis rs10883723 0.962 rs1056739 chr10:104236542 T/C cg22532475 chr10:104410764 TRIM8 -0.34 -5.67 -0.33 3.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs1185460 1.000 rs4614 chr11:118952371 A/G cg23280166 chr11:118938394 VPS11 0.43 5.64 0.33 4.25e-8 Coronary artery disease; CESC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg00149659 chr3:10157352 C3orf10 0.72 9.04 0.49 3.45e-17 Alzheimer's disease; CESC cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg12648201 chr2:27665141 KRTCAP3 -0.36 -6.31 -0.36 1.15e-9 Total body bone mineral density; CESC cis rs35110281 0.720 rs162372 chr21:44928863 C/T cg01579765 chr21:45077557 HSF2BP 0.53 8.93 0.48 7.4e-17 Mean corpuscular volume; CESC cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg03467027 chr4:99064603 C4orf37 0.45 5.61 0.33 4.97e-8 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg12963246 chr6:28129442 ZNF389 0.57 7.78 0.43 1.65e-13 Depression; CESC cis rs1904096 0.506 rs6823404 chr4:95197520 C/T cg11021082 chr4:95130006 SMARCAD1 -0.66 -10.44 -0.54 1.36e-21 Type 2 diabetes; CESC cis rs3824867 0.920 rs7948705 chr11:47447955 C/G cg20307385 chr11:47447363 PSMC3 -0.46 -5.39 -0.31 1.53e-7 Mean corpuscular hemoglobin; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24079455 chr10:127408106 C10orf137 0.58 6.78 0.38 7.93e-11 Gut microbiome composition (summer); CESC cis rs2486288 0.656 rs2413772 chr15:45549862 G/A cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.54 -0.37 3.21e-10 Glomerular filtration rate; CESC cis rs5771242 0.518 rs7290465 chr22:50679758 C/T cg16473166 chr22:50639996 SELO -0.54 -6.28 -0.36 1.34e-9 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg18252515 chr7:66147081 NA -0.46 -6.05 -0.35 5e-9 Aortic root size; CESC cis rs9303280 0.773 rs11078925 chr17:38025208 T/C cg20243544 chr17:37824526 PNMT 0.53 6.93 0.39 3.14e-11 Self-reported allergy; CESC trans rs9325144 0.647 rs12424190 chr12:39111206 A/T cg23762105 chr12:34175262 ALG10 0.45 6.07 0.35 4.45e-9 Morning vs. evening chronotype; CESC cis rs6977955 1.000 rs67250450 chr7:28174986 T/C cg23620719 chr7:28220237 JAZF1 0.6 6.69 0.38 1.29e-10 Allergic disease (asthma, hay fever or eczema); CESC cis rs7617480 0.648 rs7653408 chr3:48972351 A/C cg07636037 chr3:49044803 WDR6 0.81 11.41 0.57 8.63e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs1003719 0.591 rs2835618 chr21:38503126 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -7.94 -0.44 5.94e-14 Eye color traits; CESC cis rs8067545 1.000 rs2108980 chr17:19920518 G/A cg13482628 chr17:19912719 NA 0.48 6.37 0.36 8.11e-10 Schizophrenia; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15344021 chr17:2240169 TSR1;SGSM2 -0.43 -6.09 -0.35 4.03e-9 Gambling; CESC cis rs9859260 0.744 rs3933 chr3:195784997 C/T cg18569988 chr3:195679450 NA -0.35 -5.2 -0.3 3.9e-7 Mean corpuscular volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08118649 chr12:99038419 APAF1;IKBIP -0.48 -6.4 -0.37 7.11e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2280018 0.963 rs4985147 chr16:15168760 T/C cg27102117 chr16:15229624 NA 0.49 7.65 0.43 3.82e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs9303401 0.659 rs35103007 chr17:56900738 G/A cg02118635 chr17:56770003 RAD51C;TEX14 1.01 12.71 0.62 3.22e-29 Cognitive test performance; CESC cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg05340658 chr4:99064831 C4orf37 0.81 12.35 0.6 5.63e-28 Colonoscopy-negative controls vs population controls; CESC cis rs12497850 0.931 rs11705888 chr3:48817289 T/C cg07636037 chr3:49044803 WDR6 1.01 18.13 0.74 2.51e-48 Parkinson's disease; CESC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.89 0.39 4.03e-11 Bipolar disorder; CESC cis rs3008870 0.755 rs4655661 chr1:67408828 A/C cg02640540 chr1:67518911 SLC35D1 0.46 5.58 0.32 5.81e-8 Lymphocyte percentage of white cells; CESC cis rs4835473 0.897 rs2219912 chr4:144629062 C/T cg25736465 chr4:144833511 NA 0.4 6.24 0.36 1.74e-9 Immature fraction of reticulocytes; CESC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg26338869 chr17:61819248 STRADA 0.71 9.42 0.5 2.4e-18 Prudent dietary pattern; CESC cis rs9815354 0.812 rs17284313 chr3:41986787 G/T cg03022575 chr3:42003672 ULK4 -0.67 -6.2 -0.36 2.12e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9467711 0.606 rs12174623 chr6:26373086 C/T cg14345882 chr6:26364793 BTN3A2 0.61 6.49 0.37 4.12e-10 Autism spectrum disorder or schizophrenia; CESC cis rs2204008 0.811 rs11520277 chr12:38359611 G/A cg26384229 chr12:38710491 ALG10B 0.69 10.42 0.54 1.6e-21 Bladder cancer; CESC cis rs7216064 1.000 rs62084213 chr17:65842016 A/G cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.73e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11098499 0.730 rs12505735 chr4:120532956 G/T cg25214090 chr10:38739885 LOC399744 0.65 8.98 0.48 5.01e-17 Corneal astigmatism; CESC cis rs708547 0.874 rs1718869 chr4:57880232 A/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.56 -5.78 -0.33 2.06e-8 Response to bleomycin (chromatid breaks); CESC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg05564831 chr3:52568323 NT5DC2 0.46 7.08 0.4 1.31e-11 Electroencephalogram traits; CESC cis rs6662572 0.737 rs4660315 chr1:46270942 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.11 -0.3 6.16e-7 Blood protein levels; CESC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg07648498 chr16:89883185 FANCA 0.42 5.13 0.3 5.57e-7 Vitiligo; CESC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs8077889 0.956 rs61608877 chr17:41848713 A/C cg26893861 chr17:41843967 DUSP3 0.74 8.79 0.48 1.87e-16 Triglycerides; CESC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -10.83 -0.55 7.07e-23 Alzheimer's disease; CESC cis rs3780486 0.757 rs10813949 chr9:33123464 G/A cg13443165 chr9:33130375 B4GALT1 0.43 6.17 0.35 2.58e-9 IgG glycosylation; CESC cis rs8040855 0.627 rs4842863 chr15:85642205 T/A cg08123816 chr15:85640762 PDE8A -0.39 -5.84 -0.34 1.52e-8 Bulimia nervosa; CESC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg06634786 chr22:41940651 POLR3H -0.63 -6.6 -0.38 2.2e-10 Vitiligo; CESC cis rs9814567 0.752 rs7649910 chr3:134241310 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.44 -0.37 5.64e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg00166722 chr3:10149974 C3orf24 0.46 5.88 0.34 1.21e-8 Alzheimer's disease; CESC cis rs3747547 0.642 rs11792690 chr9:38087453 C/T cg13774184 chr9:37916125 SHB -0.63 -5.32 -0.31 2.17e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs7617773 0.780 rs13079728 chr3:48339360 A/G cg11946769 chr3:48343235 NME6 0.89 12.15 0.6 2.74e-27 Coronary artery disease; CESC cis rs453301 0.522 rs1964356 chr8:8853270 G/T cg15556689 chr8:8085844 FLJ10661 0.42 5.36 0.31 1.78e-7 Joint mobility (Beighton score); CESC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg02807482 chr3:125708958 NA -0.39 -5.11 -0.3 6.31e-7 Blood pressure (smoking interaction); CESC cis rs7551222 0.789 rs2290855 chr1:204515863 C/T cg20240347 chr1:204465584 NA -0.29 -5.87 -0.34 1.31e-8 Schizophrenia; CESC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg15605315 chr1:45957053 TESK2 0.43 5.36 0.31 1.82e-7 High light scatter reticulocyte count; CESC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg18337363 chr3:52569053 NT5DC2 0.29 5.3 0.31 2.48e-7 Bipolar disorder; CESC cis rs66887589 0.560 rs9684327 chr4:120365441 A/G cg09307838 chr4:120376055 NA 0.52 7.01 0.4 1.95e-11 Diastolic blood pressure; CESC cis rs72781680 1.000 rs12614452 chr2:24194608 C/T cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.56e-8 Lymphocyte counts; CESC cis rs3815700 1.000 rs8104729 chr19:33093979 C/T cg24916020 chr19:33096688 ANKRD27 0.6 5.84 0.34 1.56e-8 Eosinophilic esophagitis; CESC cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg02725872 chr8:58115012 NA -0.39 -5.12 -0.3 5.75e-7 Developmental language disorder (linguistic errors); CESC cis rs3820928 0.874 rs10176882 chr2:227896432 A/T cg11843606 chr2:227700838 RHBDD1 -0.42 -5.54 -0.32 7.29e-8 Pulmonary function; CESC cis rs916888 0.773 rs199439 chr17:44793503 A/G cg15921436 chr17:44337874 NA 0.76 8.29 0.45 5.64e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg22862634 chr11:62369728 EML3;MTA2 0.59 8.25 0.45 7.65e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7084402 0.967 rs10763552 chr10:60273977 C/T cg07615347 chr10:60278583 BICC1 -0.58 -9.07 -0.49 2.75e-17 Refractive error; CESC cis rs2412488 0.853 rs12508701 chr4:54353243 C/T cg22241045 chr4:54363911 LNX1 0.36 5.15 0.3 5.09e-7 DNA methylation (variation); CESC trans rs7174755 0.772 rs8025474 chr15:68386523 C/T cg00239025 chr2:96937097 CIAO1 -0.47 -6.12 -0.35 3.29e-9 Major depressive disorder; CESC cis rs1879734 0.731 rs6694399 chr1:54159198 C/T cg23596471 chr1:54105337 GLIS1 0.35 5.67 0.33 3.77e-8 Mitral valve prolapse; CESC cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.02 9.31 0.5 5.03e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25884424 chr2:113522513 CKAP2L 0.57 6.32 0.36 1.08e-9 Gut microbiome composition (summer); CESC cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg10556349 chr10:835070 NA 0.56 5.43 0.32 1.3e-7 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00846248 chr7:86849067 C7orf23 0.63 7.55 0.42 7.04e-13 Gut microbiome composition (summer); CESC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg06108461 chr20:60628389 TAF4 -0.93 -14.69 -0.67 3.68e-36 Body mass index; CESC cis rs4604732 0.603 rs10802513 chr1:247633919 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.45 6.62 0.38 2.03e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs5769765 0.954 rs1569954 chr22:50244071 C/T cg26441486 chr22:50317300 CRELD2 -0.4 -5.52 -0.32 8.04e-8 Schizophrenia; CESC cis rs72945132 0.714 rs117232799 chr11:70157182 G/A cg14191688 chr11:70257035 CTTN 0.57 6.42 0.37 6.34e-10 Coronary artery disease; CESC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg11965913 chr1:205819406 PM20D1 0.79 12.44 0.61 2.66e-28 Menarche (age at onset); CESC cis rs1707322 0.682 rs10890334 chr1:46100378 A/T cg05343316 chr1:45956843 TESK2 0.51 6.35 0.36 9.44e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9309473 1.000 rs6736866 chr2:73661986 C/G cg20560298 chr2:73613845 ALMS1 -0.55 -6.97 -0.39 2.51e-11 Metabolite levels; CESC cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg03433033 chr1:76189801 ACADM 0.59 5.77 0.33 2.22e-8 Blood metabolite levels;Acylcarnitine levels; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg20615951 chr1:246730188 CNST;TFB2M -0.54 -6.15 -0.35 2.82e-9 Subjective well-being; CESC cis rs12142240 0.770 rs112869704 chr1:46780285 C/T cg00530320 chr1:46809349 NSUN4 0.55 6.83 0.39 5.66e-11 Menopause (age at onset); CESC cis rs3753275 0.690 rs926951 chr1:8608106 A/G cg00120948 chr1:8484417 RERE -0.4 -5.03 -0.3 9.14e-7 Educational attainment; CESC cis rs35146811 0.771 rs1060544 chr7:99613476 C/T cg22906224 chr7:99728672 NA 0.49 5.77 0.33 2.23e-8 Coronary artery disease; CESC cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg02428538 chr16:24856791 SLC5A11 -0.67 -6.98 -0.39 2.39e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7572263 0.724 rs6705133 chr2:209054422 G/A cg23998903 chr2:209048830 C2orf80 -0.39 -5.14 -0.3 5.4e-7 Glioma;Non-glioblastoma glioma; CESC cis rs6460942 0.597 rs7798779 chr7:12543490 A/G cg02935154 chr7:12443704 VWDE -0.56 -5.5 -0.32 8.72e-8 Coronary artery disease; CESC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg10351095 chr21:47802916 PCNT 0.44 5.89 0.34 1.18e-8 Testicular germ cell tumor; CESC cis rs9905704 0.645 rs34852567 chr17:57027770 T/C cg12560992 chr17:57184187 TRIM37 0.64 5.79 0.34 1.97e-8 Testicular germ cell tumor; CESC cis rs11690935 0.959 rs6433314 chr2:172660971 A/G cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.68 -0.67 4.14e-36 Schizophrenia; CESC cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg03709012 chr19:19516395 GATAD2A 1.01 15.76 0.7 6.38e-40 Tonsillectomy; CESC cis rs9303401 0.659 rs12150264 chr17:56939927 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.45 0.61 2.57e-28 Cognitive test performance; CESC cis rs7539409 0.604 rs6689821 chr1:84316605 A/G cg10977910 chr1:84465055 TTLL7 0.78 7.42 0.41 1.61e-12 Alzheimer's disease; CESC trans rs4927850 0.958 rs1975582 chr3:195751439 G/T cg21051086 chr3:73046214 PPP4R2 -0.43 -6.02 -0.35 5.73e-9 Pancreatic cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11150068 chr10:111683422 XPNPEP1 0.49 6.3 0.36 1.25e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4423214 0.592 rs1790349 chr11:71142350 A/G cg05163923 chr11:71159392 DHCR7 -0.52 -5.26 -0.31 2.94e-7 Vitamin D levels; CESC cis rs2243480 0.901 rs35256305 chr7:65306405 T/C cg18252515 chr7:66147081 NA -1.01 -9.73 -0.51 2.51e-19 Diabetic kidney disease; CESC cis rs910316 0.591 rs7157158 chr14:75457238 A/G cg16144293 chr14:75469539 EIF2B2 -0.4 -5.29 -0.31 2.52e-7 Height; CESC cis rs2835872 0.758 rs1787401 chr21:39038893 C/T cg06728970 chr21:39037746 KCNJ6 0.3 5.57 0.32 6.32e-8 Electroencephalographic traits in alcoholism; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg05409038 chr2:71221890 TEX261 -0.54 -5.99 -0.35 6.64e-9 Gut microbiota (bacterial taxa); CESC cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg17414380 chr19:19431394 KIAA0892;SF4 0.48 6.27 0.36 1.45e-9 Tonsillectomy; CESC cis rs4523957 0.690 rs11078855 chr17:2091308 A/G cg16513277 chr17:2031491 SMG6 0.65 8.78 0.47 2.12e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs12458462 0.892 rs12456692 chr18:77482189 C/T cg11879182 chr18:77439856 CTDP1 0.88 13.34 0.63 2.05e-31 Monocyte count; CESC cis rs9486719 0.843 rs2499792 chr6:96846264 A/C cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC cis rs9916302 0.851 rs12936996 chr17:37665554 A/G cg07936489 chr17:37558343 FBXL20 0.8 12.04 0.59 6.17e-27 Glomerular filtration rate (creatinine); CESC cis rs9300255 0.602 rs1051431 chr12:123645803 G/A cg19016782 chr12:123741754 C12orf65 -0.4 -5.77 -0.33 2.27e-8 Neutrophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24542492 chr17:61818870 STRADA 0.59 6.62 0.38 2.02e-10 Gut microbiome composition (summer); CESC cis rs4472734 0.965 rs4655345 chr1:214608704 A/G cg00063699 chr1:214624242 PTPN14 -0.33 -5.28 -0.31 2.73e-7 Height; CESC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.7 -8.29 -0.45 5.67e-15 Alzheimer's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04145264 chr11:65190825 NEAT1 -0.44 -6.59 -0.38 2.4e-10 Gambling; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21173440 chr5:55008212 SLC38A9 -0.45 -6.42 -0.37 6.2e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs68170813 0.559 rs12533767 chr7:106860245 A/C cg02696742 chr7:106810147 HBP1 -0.52 -5.08 -0.3 7.2e-7 Coronary artery disease; CESC cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg02487422 chr3:49467188 NICN1 0.4 5.2 0.3 4.08e-7 Parkinson's disease; CESC cis rs7089973 0.604 rs35319791 chr10:116602296 C/A cg03647239 chr10:116582469 FAM160B1 0.43 5.35 0.31 1.94e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs1062177 1.000 rs892006 chr5:151180890 G/T cg12924095 chr5:151150029 G3BP1 0.51 6.77 0.38 8.32e-11 Preschool internalizing problems; CESC cis rs524281 0.861 rs10750780 chr11:65974592 G/A cg14036092 chr11:66035641 RAB1B -0.6 -6.11 -0.35 3.56e-9 Electroencephalogram traits; CESC cis rs6005807 0.543 rs2294431 chr22:29177200 C/T cg15103426 chr22:29168792 CCDC117 0.5 5.08 0.3 7.15e-7 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; CESC cis rs644799 1.000 rs566204 chr11:95580926 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.7 8.7 0.47 3.64e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs644799 1.000 rs518919 chr11:95623313 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.83 11.55 0.58 2.79e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6430585 0.528 rs309122 chr2:136761853 A/G cg07169764 chr2:136633963 MCM6 1.14 17.94 0.74 1.19e-47 Corneal structure; CESC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg10253484 chr15:75165896 SCAMP2 -0.42 -5.32 -0.31 2.23e-7 Breast cancer; CESC cis rs367943 0.666 rs7700413 chr5:112704435 T/C cg12552261 chr5:112820674 MCC 0.42 5.53 0.32 7.73e-8 Type 2 diabetes; CESC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs67311347 1.000 rs73080138 chr3:40516417 A/G cg24209194 chr3:40518798 ZNF619 0.58 7.78 0.43 1.63e-13 Renal cell carcinoma; CESC cis rs73001065 0.818 rs73004975 chr19:19727152 A/G cg03709012 chr19:19516395 GATAD2A 0.95 6.37 0.36 8.22e-10 LDL cholesterol; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24715473 chr16:50059017 TMEM188 0.53 6.92 0.39 3.46e-11 Gut microbiota (bacterial taxa); CESC cis rs6582630 0.502 rs2387603 chr12:38353389 A/C cg13010199 chr12:38710504 ALG10B 0.45 5.77 0.33 2.24e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs1570884 0.890 rs6561541 chr13:50127280 C/T cg17099306 chr13:50123645 RCBTB1 -0.4 -5.15 -0.3 5.21e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs56399783 0.901 rs73047387 chr7:2774125 G/A cg19731401 chr7:2775893 GNA12 0.69 6.02 0.35 5.85e-9 Childhood ear infection; CESC cis rs7191439 0.789 rs4598894 chr16:88776141 G/A cg02389323 chr16:88786976 FAM38A 1.0 8.0 0.44 4.02e-14 Plateletcrit; CESC cis rs367943 0.698 rs4538600 chr5:112963488 T/C cg12552261 chr5:112820674 MCC 0.45 5.8 0.34 1.88e-8 Type 2 diabetes; CESC cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.15e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg12311346 chr5:56204834 C5orf35 0.74 9.24 0.49 8.4e-18 Initial pursuit acceleration; CESC trans rs11191205 0.686 rs11191067 chr10:103379882 G/T cg12418535 chr2:119607192 EN1 -0.4 -6.0 -0.35 6.56e-9 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27238079 chr10:33247273 ITGB1 0.56 6.47 0.37 4.84e-10 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg26314531 chr2:26401878 FAM59B -0.61 -6.89 -0.39 4e-11 Gut microbiome composition (summer); CESC trans rs11098499 0.865 rs4507344 chr4:120307485 C/A cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC trans rs7246760 1.000 rs67359088 chr19:9863668 C/T cg02900749 chr2:68251473 NA -0.79 -6.66 -0.38 1.57e-10 Pursuit maintenance gain; CESC cis rs3126085 0.932 rs72696991 chr1:152250235 T/C cg03465714 chr1:152285911 FLG 0.49 5.43 0.32 1.24e-7 Atopic dermatitis; CESC cis rs4835473 0.900 rs35230778 chr4:144655489 G/A cg25736465 chr4:144833511 NA -0.33 -5.15 -0.3 5.08e-7 Immature fraction of reticulocytes; CESC trans rs9329221 0.935 rs3750311 chr8:10283602 C/A cg06636001 chr8:8085503 FLJ10661 -0.56 -6.51 -0.37 3.82e-10 Neuroticism; CESC cis rs523522 0.962 rs670568 chr12:121021206 C/T cg27279351 chr12:120934652 DYNLL1 0.7 9.06 0.49 2.86e-17 High light scatter reticulocyte count; CESC cis rs4835473 0.838 rs34505330 chr4:144656359 T/G cg25736465 chr4:144833511 NA -0.33 -5.3 -0.31 2.48e-7 Immature fraction of reticulocytes; CESC cis rs12410462 1.000 rs75198003 chr1:227623853 C/A cg04117972 chr1:227635322 NA 0.62 6.34 0.36 9.91e-10 Major depressive disorder; CESC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg23708337 chr7:1209742 NA 0.55 5.41 0.32 1.44e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2267137 0.903 rs715494 chr22:29782433 G/T cg07256473 chr22:29710276 RASL10A -0.42 -6.32 -0.36 1.08e-9 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs9325144 0.600 rs61931871 chr12:38829889 G/A cg10679878 chr6:156759499 NA -0.34 -6.07 -0.35 4.44e-9 Morning vs. evening chronotype; CESC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.52 7.0 0.4 2.05e-11 Lymphocyte counts; CESC cis rs3796352 1.000 rs7625448 chr3:53120766 C/A cg07884673 chr3:53033167 SFMBT1 0.51 5.09 0.3 6.87e-7 Immune reponse to smallpox (secreted IL-2); CESC trans rs5769765 0.773 rs58375955 chr22:50312630 A/G cg09872104 chr7:134855509 C7orf49 -0.55 -6.27 -0.36 1.47e-9 Schizophrenia; CESC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg24549020 chr5:56110836 MAP3K1 -0.55 -5.9 -0.34 1.09e-8 Initial pursuit acceleration; CESC cis rs9470366 0.848 rs9470361 chr6:36623379 G/A cg08179530 chr6:36648295 CDKN1A 0.53 6.19 0.36 2.33e-9 QRS duration; CESC cis rs7937682 1.000 rs7937682 chr11:111579939 C/G cg22437258 chr11:111473054 SIK2 0.66 7.97 0.44 4.89e-14 Primary sclerosing cholangitis; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01246405 chr11:3876562 STIM1 0.48 6.24 0.36 1.72e-9 Gut microbiota (bacterial taxa); CESC cis rs2599510 0.811 rs2754523 chr2:32837110 A/G cg02381751 chr2:32503542 YIPF4 0.51 6.42 0.37 6.26e-10 Interleukin-18 levels; CESC cis rs6502050 0.799 rs7212023 chr17:80170354 G/A cg01763666 chr17:80159506 CCDC57 -0.36 -5.13 -0.3 5.57e-7 Life satisfaction; CESC cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg22875332 chr1:76189707 ACADM -0.58 -5.96 -0.34 8.04e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2019216 0.521 rs9807074 chr17:21930856 T/C cg22648282 chr17:21454238 C17orf51 -0.39 -5.09 -0.3 6.93e-7 Pelvic organ prolapse; CESC cis rs2243480 1.000 rs313798 chr7:65493031 A/G cg12463550 chr7:65579703 CRCP 0.69 5.5 0.32 9.17e-8 Diabetic kidney disease; CESC cis rs113835537 0.529 rs3179961 chr11:66244454 A/G cg22134325 chr11:66188745 NPAS4 0.37 5.73 0.33 2.74e-8 Airway imaging phenotypes; CESC trans rs11098499 0.955 rs13113112 chr4:120156040 C/T cg25214090 chr10:38739885 LOC399744 0.64 8.56 0.47 9.18e-16 Corneal astigmatism; CESC cis rs3845702 1.000 rs3768837 chr2:180835792 T/A cg01881094 chr2:180872142 CWC22 -0.66 -7.18 -0.4 6.88e-12 Schizophrenia; CESC cis rs8002861 0.691 rs9525851 chr13:44402132 T/A cg19180546 chr13:44453867 C13orf31;CCDC122 -0.39 -5.12 -0.3 5.84e-7 Leprosy; CESC cis rs2455799 0.573 rs2062824 chr3:15757901 T/C cg09340198 chr3:15902540 ANKRD28 -0.33 -5.16 -0.3 4.91e-7 Mean platelet volume; CESC cis rs7149242 0.849 rs10146962 chr14:101170540 A/G cg18089426 chr14:101175970 NA 0.39 6.72 0.38 1.08e-10 Platelet count; CESC cis rs2882667 0.858 rs11744972 chr5:138428789 A/G cg04439458 chr5:138467593 SIL1 -0.38 -5.97 -0.34 7.49e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9393777 0.623 rs56296968 chr6:26474571 C/T cg12826209 chr6:26865740 GUSBL1 0.65 6.88 0.39 4.21e-11 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16266895 chr12:101674004 UTP20 0.48 6.22 0.36 1.88e-9 Gut microbiota (bacterial taxa); CESC cis rs965513 0.627 rs10124220 chr9:100583074 T/C cg13688889 chr9:100608707 NA -0.53 -7.75 -0.43 2e-13 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs1215050 0.791 rs783959 chr4:98893476 C/T cg05340658 chr4:99064831 C4orf37 -0.51 -6.77 -0.38 8.15e-11 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2228479 0.702 rs17233868 chr16:89803629 C/T cg14709524 chr16:89940631 TCF25 0.87 6.42 0.37 6.36e-10 Skin colour saturation; CESC trans rs2157926 1.000 rs4728709 chr7:87233602 A/G cg21546022 chr12:47052349 NA -0.58 -6.05 -0.35 4.79e-9 Bone mineral density (spine) and age at menarche; CESC cis rs1577917 1.000 rs12196037 chr6:86694631 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.31 -0.36 1.2e-9 Response to antipsychotic treatment; CESC cis rs1847202 0.517 rs13062803 chr3:72951840 T/A cg10804678 chr3:72788309 NA -0.4 -5.31 -0.31 2.34e-7 Motion sickness; CESC cis rs829880 0.558 rs249817 chr12:98896910 T/A cg25150519 chr12:98850993 NA 0.51 5.93 0.34 9.24e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3796352 0.764 rs11714902 chr3:53101544 G/C cg07884673 chr3:53033167 SFMBT1 0.69 5.92 0.34 9.89e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs708547 0.599 rs2948348 chr4:57848772 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.5 -6.74 -0.38 9.93e-11 Response to bleomycin (chromatid breaks); CESC cis rs7809950 1.000 rs4727684 chr7:107226470 C/T cg23024343 chr7:107201750 COG5 -0.44 -6.08 -0.35 4.07e-9 Coronary artery disease; CESC cis rs6502050 0.835 rs7218857 chr17:80161000 T/C cg23985595 chr17:80112537 CCDC57 -0.4 -6.35 -0.36 9.4e-10 Life satisfaction; CESC cis rs10743315 0.557 rs16915108 chr12:19290406 T/C cg02471346 chr12:19282374 PLEKHA5 0.71 5.4 0.31 1.51e-7 Gut microbiota (bacterial taxa); CESC cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg00321850 chr1:175162397 KIAA0040 -0.47 -6.6 -0.38 2.19e-10 Diastolic blood pressure; CESC cis rs1707322 0.752 rs3811435 chr1:46125790 C/A cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9911578 0.967 rs2567892 chr17:56668929 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.24 0.31 3.26e-7 Intelligence (multi-trait analysis); CESC cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg10556349 chr10:835070 NA 0.53 5.09 0.3 6.75e-7 Eosinophil percentage of granulocytes; CESC cis rs910316 0.737 rs175055 chr14:75488946 T/G cg08847533 chr14:75593920 NEK9 -0.9 -15.98 -0.7 1.06e-40 Height; CESC cis rs7605827 0.930 rs6748451 chr2:15521088 A/G cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs3026101 0.578 rs1806237 chr17:5295399 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22792938 chr2:228337242 AGFG1 0.54 6.72 0.38 1.09e-10 Gut microbiome composition (summer); CESC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg14393609 chr7:65229607 NA -0.41 -5.78 -0.33 2.1e-8 Aortic root size; CESC cis rs796364 1.000 rs281760 chr2:200787804 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.87 8.3 0.45 5.2e-15 Schizophrenia; CESC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.5e-28 Prudent dietary pattern; CESC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs4481887 1.000 rs7511706 chr1:248467360 G/A cg00666640 chr1:248458726 OR2T12 0.39 6.36 0.36 8.71e-10 Common traits (Other); CESC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg02951883 chr7:2050386 MAD1L1 -0.55 -7.14 -0.4 8.75e-12 Bipolar disorder and schizophrenia; CESC cis rs4812048 0.696 rs6070694 chr20:57591126 G/A cg14073986 chr20:57617431 SLMO2 0.84 6.04 0.35 5.23e-9 Mean platelet volume; CESC cis rs9303280 0.806 rs12232498 chr17:38040363 T/C cg19468946 chr17:37922297 IKZF3 -0.41 -5.42 -0.32 1.31e-7 Self-reported allergy; CESC cis rs7408868 0.908 rs4809028 chr19:15273231 A/G cg14696996 chr19:15285081 NOTCH3 1.11 11.47 0.58 5.57e-25 Pulse pressure; CESC trans rs2207136 0.901 rs2076309 chr6:50789451 T/C cg06522515 chr3:184090630 THPO 0.35 6.07 0.35 4.34e-9 Myopia; CESC cis rs7746199 0.673 rs35501037 chr6:27739566 T/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.82 5.56 0.32 6.51e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs28374715 0.681 rs28728213 chr15:41653602 T/A cg20272979 chr15:41787780 ITPKA 0.42 5.64 0.33 4.34e-8 Ulcerative colitis; CESC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg17376030 chr22:41985996 PMM1 0.67 7.19 0.4 6.44e-12 Vitiligo; CESC cis rs1691799 0.867 rs1027400 chr12:66760922 A/T cg16791601 chr12:66731901 HELB -0.75 -12.63 -0.61 5.94e-29 White blood cell count (basophil); CESC cis rs950776 0.518 rs12910100 chr15:78822667 C/T cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs1538970 0.884 rs1771551 chr1:45883643 C/G cg24296786 chr1:45957014 TESK2 -0.44 -5.45 -0.32 1.15e-7 Platelet count; CESC cis rs2404602 0.669 rs12595313 chr15:76978370 A/G cg26408565 chr15:76604113 ETFA -0.39 -5.72 -0.33 2.94e-8 Blood metabolite levels; CESC cis rs10751667 1.000 rs7394449 chr11:962190 T/C cg06064525 chr11:970664 AP2A2 -0.38 -6.77 -0.38 8.06e-11 Alzheimer's disease (late onset); CESC cis rs2806561 0.704 rs856510 chr1:23524407 A/C cg12483005 chr1:23474871 LUZP1 0.43 6.55 0.37 2.93e-10 Height; CESC cis rs8044868 0.521 rs7203821 chr16:72101165 T/C cg16558253 chr16:72132732 DHX38 -0.41 -6.3 -0.36 1.26e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg08109568 chr15:31115862 NA -0.7 -9.29 -0.5 5.7e-18 Huntington's disease progression; CESC cis rs11155671 0.530 rs9383577 chr6:150207195 C/T cg09699651 chr6:150184138 LRP11 0.56 7.75 0.43 2.01e-13 Testicular germ cell tumor; CESC cis rs12956009 0.518 rs10163861 chr18:44820214 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 6.38 0.37 7.74e-10 Educational attainment (years of education); CESC cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg11752832 chr7:134001865 SLC35B4 0.54 7.02 0.4 1.9e-11 Mean platelet volume; CESC cis rs6500395 0.926 rs11076570 chr16:48597915 G/A cg04672837 chr16:48644449 N4BP1 0.46 5.54 0.32 7.22e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4925386 0.840 rs6143024 chr20:60914229 A/G cg22541963 chr20:60982533 CABLES2 0.5 5.23 0.31 3.49e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs12200560 0.505 rs211165 chr6:97068520 A/T cg06623918 chr6:96969491 KIAA0776 0.46 5.85 0.34 1.47e-8 Coronary heart disease; CESC cis rs2952156 0.920 rs2952152 chr17:37832735 T/C cg07936489 chr17:37558343 FBXL20 -0.58 -7.38 -0.41 2.1e-12 Asthma; CESC cis rs4843747 0.671 rs9921236 chr16:88117015 G/T cg17633681 chr16:88106987 BANP 0.77 10.33 0.54 3.01e-21 Menopause (age at onset); CESC cis rs4253772 0.591 rs6008365 chr22:46652929 G/A cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.49 5.19 0.3 4.28e-7 LDL cholesterol;Cholesterol, total; CESC cis rs8141529 0.843 rs1065497 chr22:29279991 C/T cg02153584 chr22:29168773 CCDC117 0.56 7.11 0.4 1.1e-11 Lymphocyte counts; CESC cis rs9457247 0.967 rs382009 chr6:167403121 G/C cg23791538 chr6:167370224 RNASET2 -0.59 -8.35 -0.46 3.72e-15 Crohn's disease; CESC cis rs2479106 0.549 rs7041880 chr9:126397776 T/A cg16191174 chr9:126692580 DENND1A 0.38 5.29 0.31 2.62e-7 Polycystic ovary syndrome; CESC cis rs6089584 1.000 rs6089587 chr20:60564829 C/T cg24733560 chr20:60626293 TAF4 0.4 5.77 0.33 2.15e-8 Body mass index; CESC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg11764359 chr7:65958608 NA -0.79 -9.51 -0.5 1.18e-18 Aortic root size; CESC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg05617483 chr15:76483344 C15orf27 0.4 5.42 0.32 1.34e-7 Blood metabolite levels; CESC cis rs8180040 0.966 rs878659 chr3:47500662 G/A cg27129171 chr3:47204927 SETD2 0.62 9.24 0.49 8.07e-18 Colorectal cancer; CESC cis rs7932354 0.528 rs10838660 chr11:47152273 C/T cg25783544 chr11:47291846 MADD -0.43 -5.79 -0.34 1.99e-8 Bone mineral density (hip);Bone mineral density; CESC cis rs561341 1.000 rs508192 chr17:30315147 C/T cg00745463 chr17:30367425 LRRC37B 0.72 6.36 0.36 8.88e-10 Hip circumference adjusted for BMI; CESC cis rs11098499 0.954 rs2306455 chr4:120421969 G/A cg09307838 chr4:120376055 NA 0.93 13.08 0.63 1.67e-30 Corneal astigmatism; CESC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.5 -7.41 -0.41 1.64e-12 Total body bone mineral density; CESC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg21644426 chr2:191273491 MFSD6 -0.48 -6.65 -0.38 1.69e-10 Pulse pressure; CESC cis rs12681288 0.550 rs12549204 chr8:959085 G/T cg04851639 chr8:1020857 NA -0.28 -5.59 -0.32 5.55e-8 Schizophrenia; CESC cis rs7296418 0.663 rs28450974 chr12:123861420 G/A cg05973401 chr12:123451056 ABCB9 0.44 5.58 0.32 5.85e-8 Platelet count; CESC cis rs2070488 0.804 rs13100195 chr3:38482539 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.83 13.43 0.64 1e-31 Electrocardiographic conduction measures; CESC cis rs2120019 1.000 rs8036197 chr15:75370232 T/C cg17294928 chr15:75287854 SCAMP5 -0.59 -6.65 -0.38 1.64e-10 Blood trace element (Zn levels); CESC cis rs7084402 0.967 rs1649027 chr10:60280911 T/G cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC cis rs2732480 0.500 rs12828309 chr12:48641160 C/T cg24011408 chr12:48396354 COL2A1 0.44 6.25 0.36 1.68e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2279817 0.863 rs12757678 chr1:17983680 G/C cg21791023 chr1:18019539 ARHGEF10L -0.66 -8.09 -0.45 2.17e-14 Neuroticism; CESC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg07424592 chr7:64974309 NA 0.35 5.06 0.3 7.9e-7 Calcium levels; CESC cis rs854765 0.533 rs2955354 chr17:17948716 G/C cg04398451 chr17:18023971 MYO15A 0.73 10.55 0.54 5.95e-22 Total body bone mineral density; CESC cis rs7216064 1.000 rs2052187 chr17:65834737 T/C cg07042672 chr17:66097459 LOC651250 -0.62 -7.44 -0.42 1.39e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs8180040 1.000 rs807931 chr3:47389317 C/T cg27129171 chr3:47204927 SETD2 0.68 10.75 0.55 1.36e-22 Colorectal cancer; CESC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg18032046 chr6:28092343 ZSCAN16 0.48 5.84 0.34 1.54e-8 Depression; CESC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg21782813 chr7:2030301 MAD1L1 0.43 6.02 0.35 5.76e-9 Bipolar disorder and schizophrenia; CESC cis rs4629180 0.675 rs10195061 chr2:102093974 T/G cg21388029 chr2:102003306 CREG2 0.32 5.04 0.3 8.68e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg11644478 chr21:40555479 PSMG1 1.02 16.23 0.71 1.34e-41 Cognitive function; CESC cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4692589 1.000 rs11732126 chr4:170937416 A/G cg19918862 chr4:170955249 NA 0.37 5.76 0.33 2.36e-8 Anxiety disorder; CESC cis rs1707322 0.721 rs12049027 chr1:46118184 A/T cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9916302 0.904 rs35335692 chr17:37710006 A/G cg15445000 chr17:37608096 MED1 0.42 6.81 0.39 6.44e-11 Glomerular filtration rate (creatinine); CESC cis rs1163251 0.837 rs595283 chr1:120247887 C/G cg19096424 chr1:120255104 PHGDH -0.51 -6.46 -0.37 5e-10 Blood metabolite levels; CESC cis rs67478160 0.608 rs11160760 chr14:104248938 G/T cg08213375 chr14:104286397 PPP1R13B 0.55 11.0 0.56 2.01e-23 Schizophrenia; CESC cis rs116095464 0.614 rs10059220 chr5:242813 C/T cg22496380 chr5:211416 CCDC127 -0.96 -10.05 -0.53 2.39e-20 Breast cancer; CESC cis rs10876993 0.890 rs2640630 chr12:58067267 T/C cg18357645 chr12:58087776 OS9 0.61 10.25 0.53 5.6e-21 Celiac disease or Rheumatoid arthritis; CESC cis rs10463316 0.817 rs7701271 chr5:150776708 A/G cg03212797 chr5:150827313 SLC36A1 0.4 5.04 0.3 8.83e-7 Metabolite levels (Pyroglutamine); CESC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg10053473 chr17:62856997 LRRC37A3 0.61 8.54 0.46 1.07e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11711311 0.747 rs11928590 chr3:113343478 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.6 0.38 2.24e-10 IgG glycosylation; CESC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.52 7.13 0.4 9.37e-12 Lymphocyte counts; CESC cis rs4566357 0.930 rs1917128 chr2:227927936 G/C cg11843606 chr2:227700838 RHBDD1 -0.4 -5.17 -0.3 4.62e-7 Coronary artery disease; CESC cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs7342306 0.788 rs11832287 chr12:6291307 A/G cg23019886 chr12:6277045 NA 0.22 5.08 0.3 7.09e-7 Platelet count; CESC cis rs6748734 1.000 rs4675868 chr2:241828542 A/C cg07537917 chr2:241836409 C2orf54 -0.25 -5.14 -0.3 5.44e-7 Urinary metabolites; CESC cis rs763121 0.651 rs738249 chr22:39037979 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.54 0.46 1.1e-15 Menopause (age at onset); CESC cis rs7264396 0.697 rs6142416 chr20:34174092 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.47 5.88 0.34 1.2e-8 Total cholesterol levels; CESC cis rs2742234 0.541 rs60845448 chr10:43721462 C/T cg07801480 chr10:43725741 RASGEF1A -0.4 -5.24 -0.31 3.22e-7 Hirschsprung disease; CESC cis rs57506017 0.540 rs1435524 chr7:12262801 G/A cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.51e-7 Neuroticism; CESC cis rs7937682 0.883 rs1612013 chr11:111456293 A/G cg09085632 chr11:111637200 PPP2R1B -0.93 -13.47 -0.64 7.49e-32 Primary sclerosing cholangitis; CESC cis rs1062177 1.000 rs17804178 chr5:151197729 T/G cg12924095 chr5:151150029 G3BP1 0.5 6.44 0.37 5.44e-10 Preschool internalizing problems; CESC cis rs6484504 0.576 rs176373 chr11:31136026 G/T cg14844989 chr11:31128820 NA -0.41 -5.77 -0.33 2.19e-8 Red blood cell count; CESC cis rs7666738 0.830 rs991169 chr4:98928567 C/A cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs1355223 0.902 rs35032224 chr11:34698154 T/C cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.2 -0.36 2.15e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs72945132 0.825 rs2298411 chr11:70206046 G/A cg14191688 chr11:70257035 CTTN 0.43 5.42 0.32 1.34e-7 Coronary artery disease; CESC cis rs7918232 0.941 rs6482598 chr10:27426375 T/C cg14442939 chr10:27389572 ANKRD26 0.68 6.73 0.38 1.04e-10 Breast cancer; CESC cis rs12079745 0.793 rs75134881 chr1:169186127 T/C cg09363564 chr1:169337483 NME7;BLZF1 -1.1 -6.51 -0.37 3.77e-10 QT interval; CESC cis rs7845219 0.544 rs4735330 chr8:95917770 A/C cg13393036 chr8:95962371 TP53INP1 -0.42 -7.77 -0.43 1.69e-13 Type 2 diabetes; CESC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.73 -0.33 2.66e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg22875332 chr1:76189707 ACADM 0.7 9.65 0.51 4.56e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6594713 0.756 rs10053341 chr5:112784007 G/T cg12552261 chr5:112820674 MCC 0.54 5.23 0.31 3.48e-7 Brain cytoarchitecture; CESC cis rs9640161 0.789 rs6964110 chr7:150041836 A/C cg17279839 chr7:150038598 RARRES2 0.51 6.64 0.38 1.74e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs1707322 1.000 rs7517560 chr1:46425943 A/G cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12142240 0.698 rs6703669 chr1:46862555 C/T cg10495392 chr1:46806563 NSUN4 0.56 6.17 0.35 2.61e-9 Menopause (age at onset); CESC cis rs55871839 0.684 rs9298002 chr8:59815118 T/C cg07426533 chr8:59803705 TOX -0.51 -7.39 -0.41 1.97e-12 Pneumonia; CESC cis rs208520 1.000 rs72880045 chr6:66965232 A/C cg07460842 chr6:66804631 NA 0.9 10.34 0.54 2.79e-21 Exhaled nitric oxide output; CESC cis rs208515 0.525 rs12214310 chr6:66666308 A/G cg07460842 chr6:66804631 NA 0.83 10.33 0.54 3.09e-21 Exhaled nitric oxide levels; CESC cis rs2243480 1.000 rs1723270 chr7:65469830 T/G cg12463550 chr7:65579703 CRCP 0.68 5.46 0.32 1.09e-7 Diabetic kidney disease; CESC trans rs10242455 0.702 rs73711280 chr7:99039604 C/T cg09045935 chr12:6379348 NA 0.91 7.41 0.41 1.73e-12 Blood metabolite levels; CESC cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.31 -5.32 -0.31 2.2e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs941408 0.515 rs759067 chr19:2775668 C/T cg02580895 chr19:2754563 NA -0.41 -5.28 -0.31 2.74e-7 Total cholesterol levels; CESC cis rs7772486 0.754 rs9386132 chr6:146140751 T/C cg23711669 chr6:146136114 FBXO30 1.02 15.69 0.69 1.08e-39 Lobe attachment (rater-scored or self-reported); CESC trans rs7902708 0.920 rs7099953 chr10:54426489 G/T cg26219051 chr22:43739629 SCUBE1 -0.48 -6.19 -0.36 2.25e-9 Bone properties (heel); CESC cis rs897984 0.759 rs13708 chr16:31000809 G/A cg02466173 chr16:30829666 NA 0.48 8.16 0.45 1.32e-14 Dementia with Lewy bodies; CESC cis rs116095464 0.510 rs7714944 chr5:231765 C/T cg22496380 chr5:211416 CCDC127 -0.72 -8.33 -0.46 4.36e-15 Breast cancer; CESC cis rs17401966 1.000 rs12136376 chr1:10296452 C/T cg15208524 chr1:10270712 KIF1B 0.47 6.14 0.35 3.07e-9 Hepatocellular carcinoma; CESC cis rs6089829 0.888 rs4809468 chr20:61673566 T/C cg08564027 chr20:61660810 NA 0.91 14.61 0.67 7.09e-36 Prostate cancer (SNP x SNP interaction); CESC cis rs9788682 0.747 rs2656069 chr15:78745707 C/T cg24631222 chr15:78858424 CHRNA5 -0.61 -7.25 -0.41 4.65e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs6912958 0.712 rs9444525 chr6:88324142 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -6.63 -0.38 1.92e-10 Monocyte percentage of white cells; CESC cis rs67311347 1.000 rs56992941 chr3:40472434 A/T cg01475735 chr3:40494733 NA -0.41 -5.32 -0.31 2.17e-7 Renal cell carcinoma; CESC cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg26769984 chr7:1090371 C7orf50 0.65 7.13 0.4 9.52e-12 Bronchopulmonary dysplasia; CESC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg09359103 chr1:154839909 KCNN3 -0.65 -12.26 -0.6 1.15e-27 Prostate cancer; CESC cis rs6991838 0.557 rs13266834 chr8:66543538 C/A cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg18230493 chr5:56204884 C5orf35 -0.72 -8.78 -0.47 2.09e-16 Initial pursuit acceleration; CESC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.57 0.64 3.26e-32 Prudent dietary pattern; CESC cis rs7267979 1.000 rs2424704 chr20:25273929 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs7474896 0.537 rs2472149 chr10:38262196 A/C cg00409905 chr10:38381863 ZNF37A 0.46 5.14 0.3 5.46e-7 Obesity (extreme); CESC cis rs6011002 0.808 rs1291211 chr20:62337622 A/G cg04115418 chr20:62273971 STMN3 0.49 5.31 0.31 2.29e-7 Dental caries; CESC cis rs4919087 0.748 rs793516 chr10:98987985 G/T cg25902810 chr10:99078978 FRAT1 -0.49 -5.4 -0.31 1.5e-7 Monocyte count; CESC cis rs8062405 0.964 rs7193733 chr16:28875482 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs16854884 0.657 rs62269895 chr3:143749085 C/G cg06585982 chr3:143692056 C3orf58 0.5 6.71 0.38 1.18e-10 Economic and political preferences (feminism/equality); CESC cis rs1413885 0.516 rs6588137 chr1:65837282 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.47 6.01 0.35 6.09e-9 Anticoagulant levels; CESC cis rs7843479 0.601 rs1058486 chr8:21862551 A/G cg17168535 chr8:21777572 XPO7 0.73 11.5 0.58 4.18e-25 Mean corpuscular volume; CESC cis rs854765 0.583 rs10048206 chr17:17866897 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs2075371 1.000 rs2598296 chr7:133992985 C/T cg20476274 chr7:133979776 SLC35B4 0.67 9.67 0.51 3.81e-19 Mean platelet volume; CESC cis rs10876993 0.928 rs1689587 chr12:58075398 A/G cg18357645 chr12:58087776 OS9 0.63 10.52 0.54 7.21e-22 Celiac disease or Rheumatoid arthritis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00734895 chr19:7532157 ARHGEF18 0.47 6.03 0.35 5.6e-9 Fibrinogen levels; CESC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.51 -5.8 -0.34 1.86e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9911578 0.967 rs8075786 chr17:56819216 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -6.72 -0.38 1.11e-10 Intelligence (multi-trait analysis); CESC cis rs12188164 0.561 rs2251843 chr5:457955 C/T cg16584290 chr5:462447 EXOC3 -0.46 -7.05 -0.4 1.6e-11 Cystic fibrosis severity; CESC cis rs9487051 0.676 rs6933326 chr6:109601333 C/T cg01475377 chr6:109611718 NA -0.45 -7.24 -0.41 4.93e-12 Reticulocyte fraction of red cells; CESC cis rs8180040 0.966 rs57346147 chr3:47410564 C/G cg27129171 chr3:47204927 SETD2 -0.67 -10.29 -0.53 4.09e-21 Colorectal cancer; CESC cis rs4132509 1.000 rs73124169 chr1:243804939 T/C cg21452805 chr1:244014465 NA 0.45 5.46 0.32 1.12e-7 RR interval (heart rate); CESC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg02951883 chr7:2050386 MAD1L1 -0.58 -7.77 -0.43 1.72e-13 Bipolar disorder and schizophrenia; CESC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg05872129 chr22:39784769 NA -0.82 -11.22 -0.57 3.66e-24 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7607369 0.536 rs4646535 chr2:219664663 C/T cg02176678 chr2:219576539 TTLL4 -0.37 -6.38 -0.36 7.83e-10 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs7086627 0.515 rs10887903 chr10:82210641 C/T cg00277334 chr10:82204260 NA -0.92 -17.11 -0.72 1.02e-44 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23121350 chr17:38219361 THRA -0.61 -6.4 -0.37 6.94e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05742564 chr16:23568708 UBFD1;EARS2 0.69 8.7 0.47 3.49e-16 Gut microbiome composition (summer); CESC cis rs4268898 0.636 rs9636438 chr2:24460566 C/T cg06627628 chr2:24431161 ITSN2 0.96 11.0 0.56 1.96e-23 Asthma; CESC cis rs2228479 0.850 rs34033205 chr16:89922959 G/T cg00800038 chr16:89945340 TCF25 -0.95 -7.51 -0.42 9.15e-13 Skin colour saturation; CESC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg01516881 chr6:292596 DUSP22 -0.83 -11.37 -0.57 1.16e-24 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19484299 chr2:234775274 MSL3L2 -0.71 -8.25 -0.45 7.67e-15 Gut microbiome composition (summer); CESC cis rs12477438 0.798 rs6705583 chr2:99602625 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.6 -0.55 4.17e-22 Chronic sinus infection; CESC cis rs7927592 0.956 rs10896343 chr11:68317860 G/C cg20283391 chr11:68216788 NA -0.5 -5.89 -0.34 1.16e-8 Total body bone mineral density; CESC cis rs9467711 0.606 rs9379864 chr6:26372584 G/A cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.07e-9 Autism spectrum disorder or schizophrenia; CESC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg02099474 chr7:1027990 CYP2W1 0.34 5.09 0.3 6.76e-7 Longevity;Endometriosis; CESC cis rs61931739 0.500 rs7489132 chr12:34539712 C/T cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs10870270 0.956 rs6557 chr10:133781449 C/T cg08754478 chr10:133766260 PPP2R2D -0.59 -7.6 -0.42 5.25e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.05 0.35 4.95e-9 Colorectal cancer; CESC cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs8103278 1.000 rs8108590 chr19:46301620 A/G cg12641515 chr19:46296257 DMWD -0.52 -5.81 -0.34 1.76e-8 Coronary artery disease; CESC cis rs9796 0.870 rs2925342 chr15:41305733 A/G cg18705301 chr15:41695430 NDUFAF1 0.43 6.36 0.36 8.58e-10 Menopause (age at onset); CESC cis rs11098499 0.954 rs13151285 chr4:120314741 C/A cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg01988459 chr11:68622903 NA -0.39 -5.42 -0.32 1.37e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.65 7.91 0.44 7.12e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs35995292 0.500 rs28369620 chr7:38921872 C/T cg19327137 chr7:38886074 VPS41 0.66 10.86 0.55 5.69e-23 Subjective well-being (multi-trait analysis); CESC cis rs644799 0.965 rs10831426 chr11:95505888 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.76 0.38 8.71e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2228479 0.681 rs11641790 chr16:89961957 A/G cg06558623 chr16:89946397 TCF25 -0.58 -5.76 -0.33 2.27e-8 Skin colour saturation; CESC cis rs7666738 0.830 rs35752787 chr4:98935202 G/A cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg17372223 chr3:52568218 NT5DC2 0.43 6.3 0.36 1.25e-9 Bipolar disorder; CESC cis rs1018836 0.892 rs11776824 chr8:91553256 T/C cg16814680 chr8:91681699 NA -0.64 -9.06 -0.49 2.98e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9309473 0.687 rs6546827 chr2:73606493 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.43 -0.37 5.87e-10 Metabolite levels; CESC cis rs258892 0.895 rs13170247 chr5:72069684 A/G cg21869765 chr5:72125136 TNPO1 -0.41 -5.04 -0.3 8.82e-7 Small cell lung carcinoma; CESC cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg12386194 chr3:101231763 SENP7 0.42 5.35 0.31 1.86e-7 Colorectal cancer; CESC cis rs7259376 0.936 rs7247220 chr19:22589489 C/G cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.76e-7 Menopause (age at onset); CESC cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg23711669 chr6:146136114 FBXO30 -0.94 -12.58 -0.61 9.22e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs3026101 0.671 rs11868032 chr17:5283617 A/T cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.84 0.34 1.56e-8 Body mass index; CESC cis rs2832191 0.967 rs3787660 chr21:30520907 C/T cg08807101 chr21:30365312 RNF160 0.69 9.59 0.51 7.08e-19 Dental caries; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10996070 chr17:43025229 KIF18B -0.49 -6.07 -0.35 4.37e-9 Asthma; CESC cis rs2239547 0.657 rs6445539 chr3:52874296 G/A cg11645453 chr3:52864694 ITIH4 0.34 6.34 0.36 9.85e-10 Schizophrenia; CESC cis rs951366 0.677 rs1775140 chr1:205672107 C/A cg17178900 chr1:205818956 PM20D1 0.76 11.26 0.57 2.61e-24 Menarche (age at onset); CESC cis rs7107174 0.901 rs10899494 chr11:78122208 G/T cg02023728 chr11:77925099 USP35 0.43 5.54 0.32 7.31e-8 Testicular germ cell tumor; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg18957721 chr13:99197425 STK24 0.41 6.13 0.35 3.22e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs72949976 1.000 rs6747328 chr2:214032156 C/G cg08319019 chr2:214017104 IKZF2 -0.42 -5.38 -0.31 1.61e-7 Lung cancer;Squamous cell lung carcinoma; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09378111 chr2:211036309 C2orf67 0.47 6.21 0.36 2.03e-9 Systemic lupus erythematosus; CESC cis rs12618769 0.625 rs72819984 chr2:99044762 G/C cg10123293 chr2:99228465 UNC50 0.4 5.34 0.31 1.97e-7 Bipolar disorder; CESC cis rs9875589 0.509 rs6442423 chr3:14016062 G/A cg19554555 chr3:13937349 NA -0.44 -5.61 -0.33 5.2e-8 Ovarian reserve; CESC cis rs3741151 0.687 rs56857598 chr11:73234173 G/A cg17517138 chr11:73019481 ARHGEF17 1.05 7.72 0.43 2.46e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg24531977 chr5:56204891 C5orf35 -0.88 -11.55 -0.58 2.79e-25 Initial pursuit acceleration; CESC cis rs35955841 0.569 rs1570295 chr14:65310367 C/T cg23373153 chr14:65346875 NA 0.43 5.62 0.33 4.8e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs7786808 0.530 rs7785656 chr7:158184164 C/G cg09998033 chr7:158218633 PTPRN2 -0.44 -6.47 -0.37 4.8e-10 Obesity-related traits; CESC cis rs7707921 0.522 rs12374541 chr5:81491408 A/G cg15871215 chr5:81402204 ATG10 0.47 6.8 0.39 6.74e-11 Breast cancer; CESC cis rs9910055 0.573 rs228768 chr17:42191893 A/C cg19774624 chr17:42201019 HDAC5 -0.72 -10.72 -0.55 1.69e-22 Total body bone mineral density; CESC cis rs7424096 0.555 rs75219072 chr2:37225706 C/T cg14987922 chr2:37194071 STRN 0.49 5.42 0.32 1.34e-7 High light scatter reticulocyte percentage of red cells; CESC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg03352830 chr11:487213 PTDSS2 0.74 7.21 0.4 5.99e-12 Body mass index; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg18337363 chr3:52569053 NT5DC2 0.35 6.78 0.38 8e-11 Electroencephalogram traits; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg25031380 chr1:40157119 HPCAL4 -0.45 -6.19 -0.36 2.26e-9 Height; CESC cis rs7833986 0.501 rs2667983 chr8:56894087 T/G cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.16 0.4 8.04e-12 Height; CESC trans rs9325144 0.723 rs11169518 chr12:39177237 C/A cg23762105 chr12:34175262 ALG10 0.45 6.04 0.35 5.09e-9 Morning vs. evening chronotype; CESC cis rs400736 0.740 rs225118 chr1:8108754 G/A cg25007680 chr1:8021821 PARK7 0.58 8.17 0.45 1.3e-14 Response to antidepressants and depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16384552 chr7:74938386 SPDYE8P -0.61 -6.53 -0.37 3.35e-10 Gut microbiome composition (summer); CESC cis rs2594989 0.943 rs901865 chr3:11300707 T/C cg00170343 chr3:11313890 ATG7 0.49 5.13 0.3 5.59e-7 Circulating chemerin levels; CESC cis rs965469 0.779 rs2236112 chr20:3294983 C/G cg25506879 chr20:3388711 C20orf194 -0.48 -5.35 -0.31 1.92e-7 IFN-related cytopenia; CESC cis rs4969178 0.965 rs11077362 chr17:76397219 A/T cg05887092 chr17:76393375 PGS1 0.58 9.22 0.49 9.9e-18 HDL cholesterol levels; CESC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg14703610 chr5:56206110 C5orf35 0.54 7.32 0.41 3.03e-12 Coronary artery disease; CESC cis rs1858740 0.509 rs196375 chr3:38422919 C/T cg24069376 chr3:38537580 EXOG 0.33 5.35 0.31 1.88e-7 Schizophrenia; CESC cis rs698813 0.572 rs12613771 chr2:44490660 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.65 0.33 4.17e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs72945132 0.882 rs17425511 chr11:70183737 C/G cg00319359 chr11:70116639 PPFIA1 0.81 7.47 0.42 1.16e-12 Coronary artery disease; CESC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs1878931 0.668 rs11643983 chr16:3438865 G/A cg22508957 chr16:3507546 NAT15 -0.38 -5.58 -0.32 5.82e-8 Body mass index (adult); CESC cis rs67478160 0.608 rs4906368 chr14:104242397 A/C cg08213375 chr14:104286397 PPP1R13B 0.46 8.92 0.48 7.93e-17 Schizophrenia; CESC cis rs250677 0.522 rs891920 chr5:148369418 G/T cg18129178 chr5:148520854 ABLIM3 -0.46 -5.08 -0.3 7.01e-7 Breast cancer; CESC cis rs60843830 1.000 rs3791224 chr2:221981 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.78 9.72 0.51 2.75e-19 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs6732160 0.691 rs13432787 chr2:73430234 T/C cg01422370 chr2:73384389 NA 0.42 7.0 0.39 2.12e-11 Intelligence (multi-trait analysis); CESC cis rs7809950 0.817 rs62483725 chr7:107201575 G/A cg23024343 chr7:107201750 COG5 -0.59 -7.42 -0.41 1.64e-12 Coronary artery disease; CESC cis rs2404602 0.647 rs11072619 chr15:77043242 A/C cg23625390 chr15:77176239 SCAPER -0.47 -6.52 -0.37 3.54e-10 Blood metabolite levels; CESC cis rs992157 0.735 rs13392177 chr2:219112956 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.65 -9.06 -0.49 3e-17 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15380588 chr6:144606480 NA 0.6 6.71 0.38 1.16e-10 Gut microbiome composition (summer); CESC cis rs9549260 0.604 rs9549273 chr13:41302147 C/G cg21288729 chr13:41239152 FOXO1 -0.55 -5.26 -0.31 3.04e-7 Red blood cell count; CESC cis rs6977660 0.507 rs28402966 chr7:19774469 A/C cg05791153 chr7:19748676 TWISTNB 0.75 6.76 0.38 8.75e-11 Thyroid stimulating hormone; CESC trans rs61931739 0.853 rs7137146 chr12:34102394 G/A cg26384229 chr12:38710491 ALG10B -0.47 -6.47 -0.37 4.67e-10 Morning vs. evening chronotype; CESC cis rs208520 1.000 rs12189683 chr6:66977716 A/C cg07460842 chr6:66804631 NA -0.87 -10.11 -0.53 1.55e-20 Exhaled nitric oxide output; CESC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg07507251 chr3:52567010 NT5DC2 0.47 8.72 0.47 3.21e-16 Electroencephalogram traits; CESC cis rs7395581 0.959 rs35879051 chr11:47275882 C/G cg25783544 chr11:47291846 MADD 0.6 7.8 0.43 1.47e-13 HDL cholesterol; CESC cis rs9488822 0.676 rs7774952 chr6:116380909 A/G cg15226275 chr6:116381976 FRK 0.25 6.47 0.37 4.8e-10 Cholesterol, total;LDL cholesterol; CESC cis rs9393777 0.920 rs35869525 chr6:26946687 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.81 5.63 0.33 4.69e-8 Intelligence (multi-trait analysis); CESC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg24503407 chr1:205819492 PM20D1 -0.4 -5.57 -0.32 6.4e-8 Parkinson's disease; CESC cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg03433033 chr1:76189801 ACADM 0.68 8.23 0.45 8.38e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9633740 1.000 rs10748526 chr10:82273079 T/C cg00277334 chr10:82204260 NA -0.53 -5.68 -0.33 3.6e-8 Post bronchodilator FEV1; CESC cis rs6060717 0.536 rs11699899 chr20:34525646 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.58 0.32 6.02e-8 Hip circumference adjusted for BMI; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg26999933 chr16:11944926 RSL1D1 -0.49 -6.25 -0.36 1.61e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9435341 0.965 rs56111229 chr1:107566689 T/A cg09367891 chr1:107599246 PRMT6 0.7 8.21 0.45 9.8e-15 Facial morphology (factor 21, depth of nasal alae); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11326919 chr17:43324904 LOC100133991 0.55 6.12 0.35 3.33e-9 Gut microbiome composition (summer); CESC cis rs2635047 0.638 rs2571008 chr18:44649950 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.32 0.31 2.19e-7 Educational attainment; CESC cis rs61332075 0.540 rs55986470 chr2:239363773 A/G cg18131467 chr2:239335373 ASB1 -0.66 -5.87 -0.34 1.32e-8 Lung function (FEV1/FVC); CESC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg22549504 chr19:17448937 GTPBP3 0.5 5.56 0.32 6.74e-8 Systemic lupus erythematosus; CESC cis rs7542091 0.704 rs12022221 chr1:210046178 A/C cg22029157 chr1:209979665 IRF6 0.5 8.03 0.44 3.1e-14 Monobrow; CESC cis rs3820928 0.839 rs4673174 chr2:227801316 A/T cg05526886 chr2:227700861 RHBDD1 -0.4 -5.15 -0.3 5.12e-7 Pulmonary function; CESC cis rs7216064 0.648 rs61676547 chr17:65892507 G/C cg12091567 chr17:66097778 LOC651250 -0.74 -8.3 -0.45 5.44e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4889855 0.530 rs78012645 chr17:78550939 C/T cg16591659 chr17:78472290 NA 0.35 5.74 0.33 2.62e-8 Fractional excretion of uric acid; CESC cis rs7044106 0.762 rs1547267 chr9:123408736 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 11.04 0.56 1.44e-23 Hip circumference adjusted for BMI; CESC cis rs7100689 0.725 rs10749574 chr10:82136856 T/C cg00277334 chr10:82204260 NA -0.58 -7.29 -0.41 3.66e-12 Post bronchodilator FEV1; CESC cis rs6701037 0.566 rs10753091 chr1:175134571 T/C cg00321850 chr1:175162397 KIAA0040 0.44 6.32 0.36 1.11e-9 Alcohol dependence; CESC cis rs6547741 1.000 rs76784350 chr2:27764278 A/G cg27432699 chr2:27873401 GPN1 0.49 6.74 0.38 9.86e-11 Oral cavity cancer; CESC cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg03467027 chr4:99064603 C4orf37 0.48 5.97 0.34 7.41e-9 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg08968635 chr6:28129556 ZNF389 0.42 5.76 0.33 2.27e-8 Depression; CESC cis rs1620921 0.505 rs9456588 chr6:161212564 C/G cg01280913 chr6:161186852 NA -0.37 -5.24 -0.31 3.3e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs826838 0.967 rs34496261 chr12:39023829 G/A cg26384229 chr12:38710491 ALG10B 0.8 13.91 0.65 2.13e-33 Heart rate; CESC cis rs561341 0.882 rs111484028 chr17:30287701 G/A cg12193833 chr17:30244370 NA -0.59 -6.02 -0.35 5.78e-9 Hip circumference adjusted for BMI; CESC cis rs8114671 0.869 rs2038503 chr20:33675900 G/A cg06115741 chr20:33292138 TP53INP2 -0.44 -5.23 -0.31 3.47e-7 Height; CESC cis rs9341808 0.935 rs2298307 chr6:80816296 A/G cg08355045 chr6:80787529 NA 0.32 5.26 0.31 2.96e-7 Sitting height ratio; CESC cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg01181863 chr3:195395398 SDHAP2 -0.48 -5.6 -0.33 5.38e-8 Pancreatic cancer; CESC cis rs12971120 0.891 rs4891557 chr18:72170299 C/T cg26446133 chr18:72167187 CNDP2 -0.78 -9.58 -0.51 7.36e-19 Refractive error; CESC cis rs2066819 0.901 rs1274490 chr12:56649601 A/G cg26734620 chr12:56694298 CS -0.94 -9.79 -0.52 1.56e-19 Psoriasis vulgaris; CESC cis rs12049330 1.000 rs12049330 chr1:110031188 T/G cg05049280 chr1:110155535 GNAT2 0.43 5.06 0.3 7.87e-7 Major depressive disorder; CESC cis rs10781543 0.845 rs10781540 chr9:139321836 G/A cg14169450 chr9:139327907 INPP5E 0.54 8.47 0.46 1.7e-15 Monocyte percentage of white cells; CESC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg15595755 chr5:1867978 NA 0.51 8.24 0.45 7.89e-15 Cardiovascular disease risk factors; CESC cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg04450456 chr4:17643702 FAM184B 0.37 5.23 0.31 3.4e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7044106 0.708 rs920745 chr9:123429943 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.09 0.53 1.84e-20 Hip circumference adjusted for BMI; CESC cis rs10045504 0.502 rs17352751 chr5:38737836 G/A cg15396434 chr5:38725168 NA -0.73 -6.84 -0.39 5.61e-11 Night sleep phenotypes; CESC cis rs9303401 0.703 rs9911583 chr17:57210721 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.56 -7.21 -0.41 5.72e-12 Cognitive test performance; CESC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg10691866 chr7:65817282 TPST1 -0.32 -5.25 -0.31 3.06e-7 Aortic root size; CESC cis rs6674176 0.597 rs3762422 chr1:44400532 T/A cg13606994 chr1:44402422 ARTN -0.41 -6.52 -0.37 3.57e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9682041 0.808 rs9875109 chr3:170064776 A/G cg11886554 chr3:170076028 SKIL -0.47 -5.18 -0.3 4.49e-7 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs9399137 0.507 rs6918512 chr6:135284839 T/G cg24558204 chr6:135376177 HBS1L 0.7 9.64 0.51 4.87e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs2637266 1.000 rs12258924 chr10:78364758 G/A cg18941641 chr10:78392320 NA 0.42 7.87 0.44 8.96e-14 Pulmonary function; CESC cis rs2370759 1.000 rs11594963 chr10:32625736 G/A cg18270830 chr10:32634957 EPC1 0.7 6.76 0.38 8.99e-11 Sexual dysfunction (female); CESC cis rs2268241 0.938 rs9974603 chr21:34776300 C/A cg14850771 chr21:34775459 IFNGR2 0.92 10.85 0.55 6.4e-23 Obesity-related traits; CESC cis rs863345 0.604 rs2317970 chr1:158504770 T/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13755614 chr9:131710194 DOLK;NUP188 -0.46 -6.2 -0.36 2.17e-9 Ulcerative colitis; CESC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.25 0.41 4.65e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs854765 0.547 rs9912096 chr17:17896673 A/C cg16928487 chr17:17741425 SREBF1 -0.57 -9.84 -0.52 1.09e-19 Total body bone mineral density; CESC trans rs11051970 0.636 rs2733704 chr12:32567858 C/T cg19743254 chr11:132735814 OPCML 0.36 6.05 0.35 4.99e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs34638657 0.872 rs6420436 chr16:82186719 C/G cg09439754 chr16:82129088 HSD17B2 -0.35 -5.25 -0.31 3.12e-7 Lung adenocarcinoma; CESC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg26335602 chr6:28129616 ZNF389 0.41 5.43 0.32 1.25e-7 Parkinson's disease; CESC cis rs959260 1.000 rs4789185 chr17:73383368 C/T cg12999837 chr17:73267436 MIF4GD -0.48 -5.58 -0.32 5.89e-8 Systemic lupus erythematosus; CESC cis rs12477438 0.520 rs13010904 chr2:99754289 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.16 0.68 8.27e-38 Chronic sinus infection; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02741808 chr17:73780792 UNK -0.43 -6.11 -0.35 3.6e-9 Gambling; CESC cis rs10751667 0.643 rs10751671 chr11:944479 T/G cg06064525 chr11:970664 AP2A2 -0.5 -10.04 -0.52 2.69e-20 Alzheimer's disease (late onset); CESC trans rs561341 0.941 rs736678 chr17:30347423 G/T cg20587970 chr11:113659929 NA -1.47 -18.13 -0.74 2.44e-48 Hip circumference adjusted for BMI; CESC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg21770322 chr7:97807741 LMTK2 0.56 8.23 0.45 8.29e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs914615 0.552 rs4971088 chr1:155142883 T/A cg02153340 chr1:155202674 NA -0.37 -5.39 -0.31 1.54e-7 Urinary albumin-to-creatinine ratio; CESC cis rs4970966 0.855 rs11204701 chr1:150662179 A/T cg13175981 chr1:150552382 MCL1 0.58 6.11 0.35 3.48e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs60843830 1.000 rs56321614 chr2:268191 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.78 10.22 0.53 6.97e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7605827 0.930 rs2160693 chr2:15654669 A/T cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.65e-10 Educational attainment (years of education); CESC cis rs2075671 0.903 rs62482252 chr7:100274063 C/A cg20848291 chr7:100343083 ZAN -0.78 -9.47 -0.5 1.67e-18 Other erythrocyte phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17808635 chr1:156105758 LMNA -0.51 -6.27 -0.36 1.47e-9 Gut microbiome composition (summer); CESC cis rs7116495 1.000 rs12272213 chr11:71816219 G/A cg10381502 chr11:71823885 C11orf51 0.66 5.35 0.31 1.93e-7 Severe influenza A (H1N1) infection; CESC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg12373951 chr3:133503437 NA 0.37 5.22 0.31 3.7e-7 Iron status biomarkers; CESC cis rs17039065 1.000 rs59029263 chr4:109403907 G/A cg16022748 chr4:109541635 LOC285456;RPL34 0.66 5.45 0.32 1.15e-7 Gut microbiome composition (summer); CESC cis rs6088580 0.601 rs6059872 chr20:33082775 C/A cg24642439 chr20:33292090 TP53INP2 0.53 6.96 0.39 2.6e-11 Glomerular filtration rate (creatinine); CESC cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg05283184 chr6:79620031 NA -0.43 -6.54 -0.37 3.18e-10 Intelligence (multi-trait analysis); CESC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg13628971 chr7:2884303 GNA12 0.61 7.6 0.42 5.18e-13 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01799338 chr1:36348937 EIF2C1 -0.47 -6.35 -0.36 9.38e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9633740 1.000 rs7097656 chr10:82250831 T/C cg00277334 chr10:82204260 NA -0.57 -5.73 -0.33 2.69e-8 Post bronchodilator FEV1; CESC cis rs2440129 0.611 rs434473 chr17:6904934 A/G cg02493798 chr17:6899577 ALOX12 -0.38 -6.29 -0.36 1.31e-9 Tonsillectomy; CESC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs8050907 0.590 rs17878588 chr16:4556450 A/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.8 5.38 0.31 1.61e-7 Obesity-related traits; CESC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs12541635 0.966 rs2345070 chr8:107072027 A/G cg10147462 chr8:107024639 NA -0.37 -5.24 -0.31 3.33e-7 Age of smoking initiation; CESC cis rs921968 0.565 rs4674329 chr2:219595507 A/G cg02176678 chr2:219576539 TTLL4 -0.43 -7.6 -0.42 5.22e-13 Mean corpuscular hemoglobin concentration; CESC cis rs10504229 0.593 rs58647001 chr8:58025132 G/A cg24829409 chr8:58192753 C8orf71 -0.44 -5.68 -0.33 3.61e-8 Developmental language disorder (linguistic errors); CESC cis rs13223928 0.536 rs12700594 chr7:3156701 G/A cg19214707 chr7:3157722 NA 0.44 6.09 0.35 3.88e-9 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC trans rs2832077 0.527 rs2250141 chr21:30241984 A/T cg14791747 chr16:20752902 THUMPD1 -0.49 -6.67 -0.38 1.51e-10 Cognitive test performance; CESC cis rs4523957 0.890 rs216218 chr17:2145329 A/G cg16513277 chr17:2031491 SMG6 0.6 8.27 0.45 6.35e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg06456125 chr7:65229604 NA 0.4 5.25 0.31 3.09e-7 Aortic root size; CESC cis rs72627123 0.867 rs118113209 chr14:74432158 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.77 5.13 0.3 5.7e-7 Morning vs. evening chronotype; CESC cis rs10752881 1.000 rs10752881 chr1:182973491 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 13.28 0.63 3.33e-31 Colorectal cancer; CESC cis rs9291683 0.546 rs13110307 chr4:10044364 T/C cg00071950 chr4:10020882 SLC2A9 0.81 13.65 0.64 1.7e-32 Bone mineral density; CESC cis rs7259376 0.936 rs4932759 chr19:22540105 C/T cg02657401 chr19:22469223 NA -0.25 -5.09 -0.3 6.84e-7 Menopause (age at onset); CESC cis rs854765 0.583 rs9908832 chr17:17871068 C/T cg16928487 chr17:17741425 SREBF1 -0.52 -8.63 -0.47 5.93e-16 Total body bone mineral density; CESC cis rs56979318 1 rs56979318 chr17:80522718 A/T cg10255544 chr17:80519551 FOXK2 0.55 8.78 0.47 2.02e-16 Reticulocyte count; CESC cis rs9443645 0.527 rs2063123 chr6:79658535 T/C cg05283184 chr6:79620031 NA -0.37 -5.28 -0.31 2.63e-7 Intelligence (multi-trait analysis); CESC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg10494973 chr17:80897199 TBCD -0.48 -6.0 -0.35 6.41e-9 Breast cancer; CESC trans rs9916302 0.752 rs9901219 chr17:37558369 T/G cg04245439 chr3:142607978 PCOLCE2 -0.51 -6.19 -0.36 2.33e-9 Glomerular filtration rate (creatinine); CESC cis rs12220238 1.000 rs11000909 chr10:75944828 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.59 5.39 0.31 1.59e-7 Soluble interleukin-2 receptor subunit alpha; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20270775 chr3:28282967 CMC1 0.58 6.68 0.38 1.37e-10 Gut microbiome composition (summer); CESC cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg03433033 chr1:76189801 ACADM 0.71 9.73 0.51 2.54e-19 Blood metabolite levels;Acylcarnitine levels; CESC cis rs589448 0.538 rs622656 chr12:69753595 C/T cg14784868 chr12:69753453 YEATS4 0.74 9.73 0.51 2.42e-19 Cerebrospinal fluid biomarker levels; CESC cis rs910316 0.737 rs108621 chr14:75480637 T/C cg16144293 chr14:75469539 EIF2B2 0.39 5.11 0.3 6.03e-7 Height; CESC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg26314531 chr2:26401878 FAM59B -0.58 -6.6 -0.38 2.24e-10 Gut microbiome composition (summer); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg07387570 chr22:46663686 TTC38 0.47 6.23 0.36 1.85e-9 Tetralogy of Fallot; CESC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg27170947 chr2:26402098 FAM59B -0.56 -6.77 -0.38 8.35e-11 Gut microbiome composition (summer); CESC cis rs8038465 1.000 rs8038465 chr15:73978337 A/G cg15420318 chr15:73925796 NPTN -0.42 -5.72 -0.33 2.9e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9611565 0.918 rs4820438 chr22:41767135 C/T cg17376030 chr22:41985996 PMM1 0.56 6.12 0.35 3.41e-9 Vitiligo; CESC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg26769984 chr7:1090371 C7orf50 0.61 7.0 0.4 2.1e-11 Bronchopulmonary dysplasia; CESC cis rs360798 0.532 rs360797 chr2:62942840 C/T cg17519650 chr2:63277830 OTX1 -0.58 -7.14 -0.4 9.25e-12 Coronary artery disease; CESC cis rs3806843 0.735 rs2530242 chr5:140053351 G/C cg26395211 chr5:140044315 WDR55 0.47 5.99 0.35 6.69e-9 Depressive symptoms (multi-trait analysis); CESC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.49 -0.5 1.38e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9522267 0.535 rs2039916 chr13:112238863 A/C cg10483660 chr13:112241077 NA -0.32 -5.63 -0.33 4.64e-8 Hepatitis; CESC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg18876405 chr7:65276391 NA 0.5 6.65 0.38 1.64e-10 Aortic root size; CESC trans rs757081 0.667 rs569780 chr11:17206745 C/T cg00391031 chr10:72237473 KIAA1274 0.31 6.01 0.35 6.14e-9 Systolic blood pressure; CESC cis rs2637266 0.935 rs2579720 chr10:78399918 T/C cg18941641 chr10:78392320 NA 0.44 8.52 0.46 1.22e-15 Pulmonary function; CESC cis rs7772486 0.817 rs12198065 chr6:146385286 G/C cg23711669 chr6:146136114 FBXO30 0.88 13.06 0.63 2.03e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs10781543 0.776 rs11145760 chr9:139382594 G/A cg14169450 chr9:139327907 INPP5E 0.51 7.78 0.43 1.65e-13 Monocyte percentage of white cells; CESC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg03647317 chr4:187891568 NA 0.4 5.73 0.33 2.76e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7208859 0.623 rs216446 chr17:28933718 T/G cg19761014 chr17:28927070 LRRC37B2 0.85 6.59 0.38 2.33e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs4957048 0.577 rs56294732 chr5:568144 T/C cg25482853 chr8:67687455 SGK3 0.97 10.84 0.55 6.55e-23 Ulcerative colitis; CESC cis rs11785400 0.793 rs2978973 chr8:143747271 C/G cg24634471 chr8:143751801 JRK 0.49 5.99 0.35 6.98e-9 Schizophrenia; CESC cis rs832540 0.898 rs252888 chr5:56227326 T/A cg14703610 chr5:56206110 C5orf35 0.45 5.92 0.34 1.02e-8 Coronary artery disease; CESC cis rs13242816 1.000 rs62468978 chr7:116127099 A/G cg04696780 chr7:116139425 CAV2 -0.62 -5.68 -0.33 3.58e-8 P wave duration; CESC cis rs11166629 1.000 rs1867059 chr8:135647019 A/G cg27224718 chr8:135614730 ZFAT 0.54 6.9 0.39 3.73e-11 Smoking quantity; CESC cis rs11630290 0.736 rs7183958 chr15:64155534 C/G cg12036633 chr15:63758958 NA -0.52 -5.32 -0.31 2.22e-7 Iris characteristics; CESC cis rs11690935 0.632 rs9789538 chr2:172618474 G/C cg13550731 chr2:172543902 DYNC1I2 0.61 8.42 0.46 2.46e-15 Schizophrenia; CESC trans rs709082 0.771 rs1068686 chr3:191455571 T/A cg25305879 chr2:106814630 NA 0.4 6.33 0.36 1.03e-9 Colonoscopy-negative controls vs population controls; CESC cis rs826838 0.616 rs11182893 chr12:38627715 C/G cg26384229 chr12:38710491 ALG10B -0.45 -6.01 -0.35 5.95e-9 Heart rate; CESC trans rs7949030 0.504 rs2516633 chr11:62371773 A/C cg02469871 chr12:103218581 NA 0.32 6.19 0.36 2.33e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7264396 0.563 rs2425122 chr20:34328848 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.86 0.39 4.77e-11 Total cholesterol levels; CESC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg18252515 chr7:66147081 NA -0.47 -6.08 -0.35 4.25e-9 Aortic root size; CESC cis rs4780401 0.609 rs4781141 chr16:11808769 A/C cg01061890 chr16:11836724 TXNDC11 -0.56 -7.59 -0.42 5.59e-13 Rheumatoid arthritis; CESC cis rs2952156 1.000 rs2643195 chr17:37853118 A/G cg07936489 chr17:37558343 FBXL20 -0.52 -6.38 -0.37 7.71e-10 Asthma; CESC cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg23711669 chr6:146136114 FBXO30 0.97 14.77 0.67 2.05e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg17971929 chr21:40555470 PSMG1 1.07 16.73 0.72 2.16e-43 Cognitive function; CESC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg19077165 chr18:44547161 KATNAL2 -0.63 -9.56 -0.51 8.76e-19 Personality dimensions; CESC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.85 -0.34 1.44e-8 Total body bone mineral density; CESC trans rs1559088 0.512 rs60197880 chr19:33562695 C/A cg13714067 chr14:103989336 CKB 0.66 6.23 0.36 1.87e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs1707322 1.000 rs1768818 chr1:46514286 G/C cg05343316 chr1:45956843 TESK2 -0.44 -5.44 -0.32 1.2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg01238044 chr22:24384105 GSTT1 0.69 9.2 0.49 1.14e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg00166722 chr3:10149974 C3orf24 0.47 5.83 0.34 1.59e-8 Alzheimer's disease; CESC cis rs524281 0.861 rs2177054 chr11:65944612 C/A cg14036092 chr11:66035641 RAB1B -0.56 -5.49 -0.32 9.43e-8 Electroencephalogram traits; CESC cis rs3125734 0.633 rs4979782 chr10:63998527 C/T cg09941381 chr10:64027924 RTKN2 -0.31 -5.1 -0.3 6.39e-7 Rheumatoid arthritis; CESC cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg06627628 chr2:24431161 ITSN2 -0.67 -6.33 -0.36 1.06e-9 Lymphocyte counts; CESC cis rs2645424 0.635 rs6980952 chr8:11716473 C/G cg21281001 chr8:11725306 CTSB -0.51 -6.39 -0.37 7.42e-10 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); CESC cis rs9517313 0.770 rs9517301 chr13:99095088 A/G cg07423050 chr13:99094983 FARP1 -0.3 -5.45 -0.32 1.13e-7 Neuroticism; CESC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 1.000 rs10890378 chr1:46410657 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.63 -0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs897984 0.609 rs11862744 chr16:31057800 G/A cg00531865 chr16:30841666 NA -0.39 -5.48 -0.32 9.95e-8 Dementia with Lewy bodies; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05787931 chr3:52232012 ALAS1 0.61 7.25 0.41 4.52e-12 Gut microbiome composition (summer); CESC cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg21138405 chr5:131827807 IRF1 0.37 5.52 0.32 7.93e-8 Breast cancer;Mosquito bite size; CESC cis rs710216 0.957 rs2886876 chr1:43432741 A/G cg03128534 chr1:43423976 SLC2A1 -0.5 -5.89 -0.34 1.15e-8 Red cell distribution width; CESC cis rs25645 0.771 rs10445310 chr17:38205396 C/A cg17344932 chr17:38183730 MED24;SNORD124 0.54 7.42 0.41 1.62e-12 Myeloid white cell count; CESC cis rs1348850 0.747 rs1047884 chr2:178488281 C/G cg22681709 chr2:178499509 PDE11A -0.39 -5.92 -0.34 1e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.73 8.81 0.48 1.68e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs7615952 0.611 rs9681518 chr3:125615130 A/G cg05084668 chr3:125655381 ALG1L -0.77 -7.94 -0.44 5.82e-14 Blood pressure (smoking interaction); CESC cis rs1499972 0.938 rs846184 chr3:117749852 C/T cg07612923 chr3:117604196 NA -0.79 -5.81 -0.34 1.75e-8 Schizophrenia; CESC cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg05340658 chr4:99064831 C4orf37 0.76 11.15 0.57 6.32e-24 Colonoscopy-negative controls vs population controls; CESC cis rs1595825 0.735 rs6752760 chr2:198918164 G/T cg10820045 chr2:198174542 NA 0.42 5.21 0.3 3.79e-7 Ulcerative colitis; CESC cis rs1801251 1.000 rs4973053 chr2:233670099 G/A cg08000102 chr2:233561755 GIGYF2 -0.67 -9.77 -0.51 1.93e-19 Coronary artery disease; CESC cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg22875332 chr1:76189707 ACADM 0.64 6.42 0.37 6.23e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs919433 0.889 rs788004 chr2:198219032 C/T cg03934865 chr2:198174659 NA 0.44 6.47 0.37 4.71e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9650657 0.504 rs10093053 chr8:11037187 T/C cg21775007 chr8:11205619 TDH -0.39 -5.56 -0.32 6.47e-8 Neuroticism; CESC cis rs9325144 0.560 rs7980358 chr12:38640396 C/G cg26384229 chr12:38710491 ALG10B 0.59 8.26 0.45 7.18e-15 Morning vs. evening chronotype; CESC trans rs2797160 0.714 rs1777220 chr6:126022602 G/T cg05039488 chr6:79577232 IRAK1BP1 0.51 6.88 0.39 4.41e-11 Endometrial cancer; CESC cis rs4737010 0.501 rs55694640 chr8:41649439 T/G cg08923054 chr8:41654455 ANK1 0.6 7.42 0.41 1.55e-12 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.29 0.45 5.87e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg25072359 chr17:41440525 NA 0.47 6.42 0.37 6.23e-10 Menopause (age at onset); CESC cis rs826838 0.967 rs1719858 chr12:39124505 C/T cg13010199 chr12:38710504 ALG10B -0.46 -6.44 -0.37 5.5e-10 Heart rate; CESC cis rs6964587 1.000 rs2097739 chr7:91711466 C/T cg17063962 chr7:91808500 NA 0.59 8.22 0.45 9.37e-15 Breast cancer; CESC cis rs62064224 0.765 rs62065463 chr17:30732405 G/T cg24550644 chr17:30846204 MYO1D -0.35 -5.03 -0.3 8.94e-7 Schizophrenia; CESC cis rs7267979 0.933 rs2424708 chr20:25281398 C/T cg08601574 chr20:25228251 PYGB 0.36 5.09 0.3 6.75e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs12477438 0.520 rs6542865 chr2:99764521 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.81 0.7 4.17e-40 Chronic sinus infection; CESC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg00431813 chr7:1051703 C7orf50 0.35 5.47 0.32 1.03e-7 Longevity;Endometriosis; CESC cis rs826838 0.616 rs9668847 chr12:38614669 C/T cg26384229 chr12:38710491 ALG10B 0.46 6.62 0.38 1.96e-10 Heart rate; CESC cis rs11077998 0.935 rs12185276 chr17:80498997 T/C cg10255544 chr17:80519551 FOXK2 0.55 8.85 0.48 1.27e-16 Reticulocyte fraction of red cells; CESC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg17724175 chr1:150552817 MCL1 0.42 6.33 0.36 1.02e-9 Melanoma; CESC cis rs919433 0.680 rs4685 chr2:198257795 C/T cg03934865 chr2:198174659 NA -0.38 -5.09 -0.3 6.76e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2050392 0.965 rs1543725 chr10:30698873 A/G cg18806716 chr10:30721971 MAP3K8 -0.42 -6.04 -0.35 5.11e-9 Inflammatory bowel disease; CESC cis rs56104184 0.775 rs17272707 chr19:49404535 T/G cg15549821 chr19:49342101 PLEKHA4 -0.53 -5.47 -0.32 1.06e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg21573476 chr21:45109991 RRP1B -0.49 -6.82 -0.39 6.32e-11 Mean corpuscular volume; CESC cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg05347473 chr6:146136440 FBXO30 -0.54 -6.88 -0.39 4.35e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1267303 0.537 rs59935547 chr1:47001423 A/G cg25110126 chr1:46999211 NA 0.84 10.81 0.55 8.55e-23 Monobrow; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04113056 chr14:64010798 PPP2R5E 0.58 7.25 0.41 4.58e-12 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27362115 chr11:65172423 FRMD8 0.48 6.19 0.36 2.24e-9 Fibrinogen levels; CESC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg02951883 chr7:2050386 MAD1L1 -0.48 -6.46 -0.37 5.05e-10 Bipolar disorder and schizophrenia; CESC cis rs9911578 1.000 rs2270097 chr17:56572070 G/A cg12560992 chr17:57184187 TRIM37 -0.92 -15.44 -0.69 8.54e-39 Intelligence (multi-trait analysis); CESC cis rs17376456 0.825 rs17374166 chr5:93238655 T/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.24 0.31 3.26e-7 Diabetic retinopathy; CESC cis rs66573146 0.572 rs66611116 chr4:6953270 A/G cg00086871 chr4:6988644 TBC1D14 1.03 6.92 0.39 3.38e-11 Granulocyte percentage of myeloid white cells; CESC cis rs2276314 0.857 rs62101402 chr18:33629435 A/G cg05985134 chr18:33552581 C18orf21 0.62 7.36 0.41 2.32e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs752010 0.631 rs1073197 chr1:42059822 C/T cg06885757 chr1:42089581 HIVEP3 -0.68 -11.01 -0.56 1.83e-23 Lupus nephritis in systemic lupus erythematosus; CESC cis rs11098499 0.908 rs11729050 chr4:120300066 T/C cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC trans rs1994135 0.654 rs1447872 chr12:33718343 C/A cg26384229 chr12:38710491 ALG10B 0.56 7.59 0.42 5.47e-13 Resting heart rate; CESC cis rs35146811 0.806 rs1534310 chr7:99699169 A/T cg13334819 chr7:99746414 C7orf59 -0.44 -5.24 -0.31 3.34e-7 Coronary artery disease; CESC cis rs703842 0.642 rs73123375 chr12:58063664 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.5 5.34 0.31 1.95e-7 Multiple sclerosis; CESC cis rs6460942 1.000 rs62448565 chr7:12400458 G/A cg20607287 chr7:12443886 VWDE -0.67 -7.7 -0.43 2.67e-13 Coronary artery disease; CESC cis rs7408868 0.908 rs10416777 chr19:15276923 C/T cg14696996 chr19:15285081 NOTCH3 1.11 11.51 0.58 3.92e-25 Pulse pressure; CESC trans rs1814175 0.817 rs1794162 chr11:49899506 A/C cg15704280 chr7:45808275 SEPT13 -1.03 -21.21 -0.79 4.77e-59 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03674076 chr20:524243 CSNK2A1 0.59 7.0 0.4 2.11e-11 Gut microbiome composition (summer); CESC cis rs7727544 0.684 rs272889 chr5:131665378 A/G cg07395648 chr5:131743802 NA -0.43 -5.67 -0.33 3.64e-8 Blood metabolite levels; CESC cis rs2439831 0.867 rs2412778 chr15:43660982 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.92 11.04 0.56 1.5e-23 Lung cancer in ever smokers; CESC cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.65 7.91 0.44 7.12e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs6748734 1.000 rs4344931 chr2:241818527 A/C cg04034577 chr2:241836375 C2orf54 -0.48 -8.43 -0.46 2.17e-15 Urinary metabolites; CESC cis rs9911578 0.967 rs7222789 chr17:56819853 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.21 0.3 3.88e-7 Intelligence (multi-trait analysis); CESC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg19680485 chr15:31195859 MTMR15 0.5 6.05 0.35 4.83e-9 Huntington's disease progression; CESC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg05863683 chr7:1912471 MAD1L1 0.42 6.21 0.36 2.09e-9 Bipolar disorder and schizophrenia; CESC cis rs4919087 0.892 rs10786319 chr10:99008951 T/C cg25902810 chr10:99078978 FRAT1 0.64 9.06 0.49 2.9e-17 Monocyte count; CESC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.98 -0.56 2.38e-23 Alzheimer's disease; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg03221778 chr16:89284213 ZNF778 0.44 6.16 0.35 2.72e-9 Post-traumatic stress disorder; CESC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg18032046 chr6:28092343 ZSCAN16 -0.42 -5.55 -0.32 6.99e-8 Cardiac Troponin-T levels; CESC cis rs6582630 0.513 rs11181246 chr12:38302670 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs933688 0.536 rs332537 chr5:90794973 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.86 -8.33 -0.46 4.48e-15 Smoking behavior; CESC cis rs4699052 0.963 rs6816055 chr4:104143160 T/C cg16532752 chr4:104119610 CENPE -0.39 -5.35 -0.31 1.9e-7 Testicular germ cell tumor; CESC cis rs3746446 0.678 rs6120777 chr20:33560172 G/A cg24642439 chr20:33292090 TP53INP2 0.69 6.06 0.35 4.72e-9 Congenital left-sided heart lesions; CESC cis rs7267979 0.966 rs2482918 chr20:25412135 C/T cg08601574 chr20:25228251 PYGB -0.36 -5.13 -0.3 5.55e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs12586317 0.508 rs10134914 chr14:35425012 T/G cg05294307 chr14:35346193 BAZ1A -0.51 -6.37 -0.36 8.28e-10 Psoriasis; CESC cis rs12458462 0.859 rs34242155 chr18:77425192 G/A cg23301140 chr18:77439876 CTDP1 0.57 7.41 0.41 1.74e-12 Monocyte count; CESC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg06481639 chr22:41940642 POLR3H 0.6 5.92 0.34 9.88e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg11494091 chr17:61959527 GH2 0.76 13.36 0.63 1.73e-31 Prudent dietary pattern; CESC cis rs9467711 0.584 rs34244947 chr6:26761745 T/C cg14345882 chr6:26364793 BTN3A2 0.64 5.81 0.34 1.8e-8 Autism spectrum disorder or schizophrenia; CESC cis rs3096299 0.606 rs4785573 chr16:89565403 A/G cg16743903 chr16:89593216 SPG7 -0.53 -6.65 -0.38 1.7e-10 Multiple myeloma (IgH translocation); CESC trans rs1814175 0.935 rs7950947 chr11:49668369 C/T cg03929089 chr4:120376271 NA -0.87 -13.36 -0.63 1.83e-31 Height; CESC cis rs61931739 0.533 rs4270002 chr12:34313126 G/T cg19457237 chr12:34500585 NA -0.42 -5.67 -0.33 3.79e-8 Morning vs. evening chronotype; CESC cis rs7927592 0.956 rs7126340 chr11:68257293 C/T cg20283391 chr11:68216788 NA -0.5 -6.14 -0.35 2.96e-9 Total body bone mineral density; CESC cis rs10256972 0.527 rs2949170 chr7:1216438 A/G cg09177884 chr7:1199841 ZFAND2A -0.63 -8.04 -0.44 3.08e-14 Longevity;Endometriosis; CESC cis rs10905065 0.931 rs11255228 chr10:5837671 T/C cg11519256 chr10:5708881 ASB13 0.45 6.22 0.36 1.9e-9 Menopause (age at onset); CESC trans rs11098499 0.863 rs3733525 chr4:120447048 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.68 0.51 3.69e-19 Corneal astigmatism; CESC cis rs6547741 0.935 rs4666004 chr2:27855052 T/A cg27432699 chr2:27873401 GPN1 0.45 6.16 0.35 2.7e-9 Oral cavity cancer; CESC cis rs12458462 0.892 rs3786228 chr18:77464170 C/T cg11879182 chr18:77439856 CTDP1 -0.86 -13.87 -0.65 3.01e-33 Monocyte count; CESC cis rs11758351 0.660 rs2143345 chr6:26229148 C/T cg23601095 chr6:26197514 HIST1H3D 0.91 9.93 0.52 5.8e-20 Gout;Renal underexcretion gout; CESC cis rs950169 0.922 rs11635505 chr15:85097034 A/C cg17507749 chr15:85114479 UBE2QP1 -0.59 -6.75 -0.38 9.1e-11 Schizophrenia; CESC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg14983838 chr19:29218262 NA 0.5 6.1 0.35 3.67e-9 Methadone dose in opioid dependence; CESC cis rs1401999 0.668 rs6806313 chr3:183642152 G/C cg01324343 chr3:183735012 ABCC5 0.47 9.48 0.5 1.47e-18 Anterior chamber depth; CESC cis rs7116495 1.000 rs610041 chr11:71797968 A/G cg10381502 chr11:71823885 C11orf51 -0.66 -5.4 -0.31 1.51e-7 Severe influenza A (H1N1) infection; CESC cis rs116095464 0.558 rs10052012 chr5:231908 T/C cg22857025 chr5:266934 NA -1.29 -18.53 -0.75 9.59e-50 Breast cancer; CESC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg18099408 chr3:52552593 STAB1 -0.33 -5.49 -0.32 9.35e-8 Bipolar disorder; CESC cis rs208520 0.661 rs150263 chr6:66777620 T/C cg07460842 chr6:66804631 NA -0.99 -13.11 -0.63 1.36e-30 Exhaled nitric oxide output; CESC cis rs4835473 0.832 rs35398499 chr4:144658868 C/A cg25736465 chr4:144833511 NA -0.33 -5.2 -0.3 4.08e-7 Immature fraction of reticulocytes; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20540378 chr5:149340137 SLC26A2 -0.47 -6.17 -0.35 2.58e-9 Height; CESC cis rs933688 0.532 rs2367292 chr5:90556785 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.45 -5.21 -0.3 3.74e-7 Smoking behavior; CESC cis rs911555 0.504 rs8021368 chr14:104074810 G/A cg24130564 chr14:104152367 KLC1 -0.8 -12.94 -0.62 5.2e-30 Intelligence (multi-trait analysis); CESC cis rs3892630 0.588 rs8106748 chr19:33282797 G/A cg22980127 chr19:33182716 NUDT19 1.13 14.68 0.67 4.09e-36 Red blood cell traits; CESC cis rs8092503 1.000 rs7236335 chr18:52475073 G/A cg12377874 chr18:52495404 RAB27B 0.38 6.13 0.35 3.17e-9 Childhood body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21140054 chr3:42632404 SS18L2 -0.43 -6.64 -0.38 1.82e-10 Gambling; CESC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg19774624 chr17:42201019 HDAC5 0.84 13.09 0.63 1.55e-30 Total body bone mineral density; CESC cis rs1185460 0.934 rs10892328 chr11:118942654 T/A cg23280166 chr11:118938394 VPS11 0.51 6.51 0.37 3.82e-10 Coronary artery disease; CESC cis rs8070740 0.617 rs9908179 chr17:5323631 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.56 7.49 0.42 1.05e-12 Menopause (age at onset); CESC cis rs57221529 0.766 rs12521051 chr5:560440 A/G cg16447950 chr5:562315 NA 0.69 8.06 0.44 2.59e-14 Lung disease severity in cystic fibrosis; CESC cis rs7219021 0.705 rs2270576 chr17:47007963 C/T cg16584676 chr17:46985605 UBE2Z -0.62 -7.06 -0.4 1.46e-11 Schizophrenia or bipolar disorder; CESC cis rs4891159 0.790 rs72975925 chr18:74143902 G/A cg24786174 chr18:74118243 ZNF516 -0.74 -10.97 -0.56 2.44e-23 Longevity; CESC trans rs11098499 0.604 rs12642411 chr4:120580525 T/C cg25214090 chr10:38739885 LOC399744 0.62 8.15 0.45 1.47e-14 Corneal astigmatism; CESC cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg23887609 chr12:130822674 PIWIL1 0.46 5.99 0.35 6.63e-9 Menopause (age at onset); CESC cis rs863345 0.604 rs1342952 chr1:158464430 C/A cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs4660306 0.961 rs3748643 chr1:45965703 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.61 -7.69 -0.43 2.86e-13 Homocysteine levels; CESC cis rs2742417 0.624 rs2673030 chr3:45757900 T/G cg04837898 chr3:45731254 SACM1L -0.48 -6.55 -0.37 2.96e-10 Response to anti-depressant treatment in major depressive disorder; CESC cis rs9911578 0.967 rs8082544 chr17:57185807 C/T cg05425664 chr17:57184151 TRIM37 0.53 7.3 0.41 3.31e-12 Intelligence (multi-trait analysis); CESC cis rs11683229 0.704 rs11683005 chr2:63302629 C/T cg17519650 chr2:63277830 OTX1 -0.7 -5.48 -0.32 9.76e-8 Protein quantitative trait loci; CESC trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg15556689 chr8:8085844 FLJ10661 -0.58 -7.68 -0.43 3.16e-13 Neuroticism; CESC cis rs2315504 0.509 rs2051806 chr17:39031451 C/T cg05063374 chr17:38953512 KRT28 -0.42 -5.92 -0.34 9.99e-9 Height; CESC cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg25517755 chr10:38738941 LOC399744 -0.47 -6.05 -0.35 4.86e-9 Extrinsic epigenetic age acceleration; CESC cis rs7000551 0.689 rs6996872 chr8:22316753 T/C cg12081754 chr8:22256438 SLC39A14 0.39 5.13 0.3 5.57e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs9303280 0.806 rs35569035 chr17:38035624 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.49 -0.32 9.59e-8 Self-reported allergy; CESC cis rs909002 0.800 rs3753613 chr1:32082000 C/T cg13919466 chr1:32135498 COL16A1 0.46 8.24 0.45 7.88e-15 Intelligence (multi-trait analysis); CESC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.36 -5.73 -0.33 2.69e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs10392 0.543 rs748063 chr20:37548730 A/G cg27552599 chr20:37590471 DHX35 0.39 5.67 0.33 3.77e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs611744 0.647 rs587340 chr8:109246032 C/A cg21045802 chr8:109455806 TTC35 0.46 5.72 0.33 2.92e-8 Dupuytren's disease; CESC cis rs9614461 0.826 rs9614649 chr22:45746097 C/A cg13318129 chr22:45737514 FAM118A 0.54 5.81 0.34 1.75e-8 Tonsillectomy; CESC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg02569458 chr12:86230093 RASSF9 -0.48 -7.27 -0.41 3.94e-12 Major depressive disorder; CESC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.5 -0.37 3.97e-10 Bipolar disorder; CESC cis rs1163251 0.837 rs839612 chr1:120247176 T/C cg19096424 chr1:120255104 PHGDH 0.52 6.67 0.38 1.52e-10 Blood metabolite levels; CESC cis rs16895831 0.549 rs12204274 chr6:42607841 C/T cg10605015 chr6:42532144 UBR2 -0.48 -5.33 -0.31 2.06e-7 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs12142240 0.698 rs66847432 chr1:46832013 G/A cg10495392 chr1:46806563 NSUN4 0.57 6.24 0.36 1.74e-9 Menopause (age at onset); CESC cis rs897984 0.609 rs55979739 chr16:31049155 A/G cg02466173 chr16:30829666 NA -0.42 -7.18 -0.4 6.88e-12 Dementia with Lewy bodies; CESC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg19622623 chr12:86230825 RASSF9 -0.48 -6.11 -0.35 3.64e-9 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09901100 chr7:134867116 NA -0.58 -6.22 -0.36 1.98e-9 Gut microbiome composition (summer); CESC cis rs314370 0.951 rs17884589 chr7:100493711 G/A cg10426581 chr7:100472382 SRRT 0.84 8.18 0.45 1.23e-14 Resting heart rate; CESC cis rs2952156 0.920 rs9303274 chr17:37836353 T/C cg20243544 chr17:37824526 PNMT 0.64 8.63 0.47 5.62e-16 Asthma; CESC cis rs6732160 0.613 rs58317144 chr2:73388153 C/T cg01422370 chr2:73384389 NA 0.54 8.62 0.47 6.17e-16 Intelligence (multi-trait analysis); CESC cis rs2425143 0.818 rs12481545 chr20:34407698 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -6.16 -0.35 2.65e-9 Blood protein levels; CESC cis rs7714584 1.000 rs1428552 chr5:150259831 T/C cg22134413 chr5:150180641 NA 0.47 5.23 0.31 3.45e-7 Crohn's disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04590956 chr2:70057467 GMCL1 0.52 6.91 0.39 3.57e-11 Systemic lupus erythematosus; CESC cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg13798912 chr7:905769 UNC84A 0.6 6.08 0.35 4.24e-9 Cerebrospinal P-tau181p levels; CESC cis rs9914544 1.000 rs9914544 chr17:18787828 A/C cg26378065 chr17:18585709 ZNF286B 0.46 5.62 0.33 4.89e-8 Educational attainment (years of education); CESC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.65 -9.06 -0.49 2.99e-17 Menopause (age at onset); CESC trans rs11971186 0.824 rs1204522 chr7:126507693 C/G cg10894441 chr11:111169905 C11orf92;C11orf93 -0.52 -6.54 -0.37 3.09e-10 Chemerin levels; CESC cis rs7084402 0.967 rs7078900 chr10:60273430 G/A cg07615347 chr10:60278583 BICC1 -0.56 -8.58 -0.47 7.96e-16 Refractive error; CESC cis rs6964587 0.869 rs7778667 chr7:91520816 C/G cg17063962 chr7:91808500 NA -0.53 -6.97 -0.39 2.58e-11 Breast cancer; CESC cis rs9399135 0.967 rs1023179 chr6:135343829 T/A cg24558204 chr6:135376177 HBS1L 0.52 7.29 0.41 3.48e-12 Red blood cell count; CESC cis rs17253792 0.822 rs77761669 chr14:56034216 G/A cg01858014 chr14:56050164 KTN1 -0.82 -6.56 -0.37 2.83e-10 Putamen volume; CESC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg11890956 chr21:40555474 PSMG1 1.17 21.44 0.8 7.97e-60 Cognitive function; CESC cis rs6088580 0.524 rs6088575 chr20:33273403 C/T cg07148914 chr20:33460835 GGT7 0.42 5.34 0.31 1.96e-7 Glomerular filtration rate (creatinine); CESC cis rs698833 0.962 rs1067387 chr2:44642797 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 6.48 0.37 4.47e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs10256972 0.527 rs28671326 chr7:1174973 G/A cg18765753 chr7:1198926 ZFAND2A -0.45 -6.61 -0.38 2.1e-10 Longevity;Endometriosis; CESC cis rs2204008 0.583 rs12307593 chr12:38317803 A/G cg26384229 chr12:38710491 ALG10B 0.4 5.33 0.31 2.06e-7 Bladder cancer; CESC cis rs17666538 0.535 rs1669613 chr8:617565 G/C cg23958373 chr8:599963 NA 0.83 6.1 0.35 3.7e-9 IgG glycosylation; CESC cis rs847577 0.609 rs705308 chr7:97695363 C/A cg24562669 chr7:97807699 LMTK2 -0.79 -13.68 -0.64 1.38e-32 Breast cancer; CESC cis rs7178909 0.902 rs3853640 chr15:90443720 A/C cg19708238 chr15:90437601 AP3S2 0.41 5.63 0.33 4.59e-8 Common traits (Other); CESC cis rs4253772 0.591 rs6520010 chr22:46721223 G/A cg24881330 chr22:46731750 TRMU 0.91 10.0 0.52 3.44e-20 LDL cholesterol;Cholesterol, total; CESC cis rs11249608 0.789 rs903989 chr5:178434434 C/T cg01312482 chr5:178451176 ZNF879 -0.43 -6.06 -0.35 4.74e-9 Pubertal anthropometrics; CESC trans rs11088226 0.801 rs2833886 chr21:33923872 C/A cg09050820 chr6:167586206 TCP10L2 0.64 6.93 0.39 3.21e-11 Gastritis; CESC cis rs829661 0.532 rs9789517 chr2:30785824 C/G cg12454169 chr2:30669597 LCLAT1 0.43 5.36 0.31 1.84e-7 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs9549367 0.713 rs510160 chr13:113822481 A/G cg18105134 chr13:113819100 PROZ 0.57 7.36 0.41 2.26e-12 Platelet distribution width; CESC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg08888203 chr3:10149979 C3orf24 0.48 6.1 0.35 3.84e-9 Alzheimer's disease; CESC cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg03433033 chr1:76189801 ACADM -0.68 -7.3 -0.41 3.37e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs761746 0.960 rs5753733 chr22:32027922 A/G cg25791279 chr22:32026902 PISD 0.56 6.75 0.38 9.26e-11 Intelligence; CESC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg27535305 chr1:53392650 SCP2 0.31 5.51 0.32 8.71e-8 Monocyte count; CESC cis rs1003719 0.523 rs1063949 chr21:38574675 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.02 -0.44 3.34e-14 Eye color traits; CESC cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.13 0.3 5.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs796364 0.806 rs11684895 chr2:201009026 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -6.83 -0.39 5.71e-11 Schizophrenia; CESC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg13206674 chr6:150067644 NUP43 0.41 5.74 0.33 2.64e-8 Lung cancer; CESC cis rs7223966 1.000 rs8075422 chr17:61804686 G/A cg11494091 chr17:61959527 GH2 0.39 5.4 0.32 1.46e-7 Hip circumference adjusted for BMI;Body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22333733 chr11:31391482 DNAJC24;DCDC1 -0.46 -6.77 -0.38 8.08e-11 Gut microbiota (bacterial taxa); CESC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.23 -0.31 3.53e-7 Life satisfaction; CESC cis rs2070488 0.965 rs2284819 chr3:38557161 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 15.51 0.69 4.6e-39 Electrocardiographic conduction measures; CESC cis rs1215050 0.740 rs1084777 chr4:99017542 C/T cg05340658 chr4:99064831 C4orf37 -0.58 -7.81 -0.43 1.38e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs965469 1.000 rs6037538 chr20:3282978 T/C cg25506879 chr20:3388711 C20orf194 -0.54 -5.88 -0.34 1.21e-8 IFN-related cytopenia; CESC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg00166722 chr3:10149974 C3orf24 0.54 6.89 0.39 4.08e-11 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24402755 chr1:87380200 HS2ST1;SEP15 0.58 6.28 0.36 1.4e-9 Gut microbiome composition (summer); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09845883 chr1:154197610 UBAP2L -0.47 -6.31 -0.36 1.17e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg04553112 chr3:125709451 NA -0.51 -5.38 -0.31 1.65e-7 Blood pressure (smoking interaction); CESC cis rs1538970 0.962 rs9429075 chr1:45818421 G/A cg03146154 chr1:46216737 IPP 0.45 5.39 0.31 1.54e-7 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03066657 chr11:9116583 FLJ46111 -0.51 -6.47 -0.37 4.76e-10 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg16339924 chr4:17578868 LAP3 0.84 10.82 0.55 7.97e-23 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs208520 0.955 rs12216176 chr6:67005130 G/T cg07460842 chr6:66804631 NA 0.77 8.82 0.48 1.57e-16 Exhaled nitric oxide output; CESC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg02221750 chr19:17393354 ANKLE1 0.53 6.29 0.36 1.3e-9 Systemic lupus erythematosus; CESC cis rs3015497 0.587 rs1353204 chr14:51081515 C/T cg09863266 chr14:51125203 SAV1 -0.32 -5.03 -0.3 9e-7 Mean platelet volume; CESC cis rs1050631 0.564 rs681757 chr18:33744766 A/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.6 8.31 0.45 5.09e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs2637266 0.678 rs846606 chr10:78562819 A/T cg18941641 chr10:78392320 NA -0.39 -7.45 -0.42 1.29e-12 Pulmonary function; CESC cis rs2832191 0.716 rs1984012 chr21:30392472 T/C cg24692254 chr21:30365293 RNF160 1.02 18.45 0.75 1.95e-49 Dental caries; CESC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg23281280 chr6:28129359 ZNF389 0.44 6.4 0.37 7.19e-10 Cardiac Troponin-T levels; CESC cis rs2280018 1.000 rs2280018 chr16:15150833 A/C cg27102117 chr16:15229624 NA 0.49 7.7 0.43 2.78e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs17608059 0.566 rs17676459 chr17:13910515 A/G cg11395062 chr17:14139857 CDRT15 0.45 5.59 0.32 5.61e-8 Temperament; CESC cis rs709400 0.663 rs72708893 chr14:103929535 G/A cg12935359 chr14:103987150 CKB -0.57 -8.37 -0.46 3.41e-15 Body mass index; CESC cis rs6782228 1.000 rs12495411 chr3:128395695 G/A cg15607142 chr3:128420513 NA -0.39 -5.21 -0.3 3.85e-7 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; CESC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs965469 0.947 rs965470 chr20:3381588 C/G cg25506879 chr20:3388711 C20orf194 -0.57 -6.1 -0.35 3.75e-9 IFN-related cytopenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09333889 chr11:18211133 NA -0.61 -7.79 -0.43 1.55e-13 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs7772486 0.790 rs7753696 chr6:146279098 G/T cg23711669 chr6:146136114 FBXO30 -0.93 -13.48 -0.64 6.97e-32 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19001237 chr11:18548595 TSG101 -0.55 -6.18 -0.35 2.39e-9 Gut microbiome composition (summer); CESC cis rs10242455 0.702 rs55927283 chr7:99057191 G/C cg13560068 chr7:99070416 ZNF789 0.66 5.06 0.3 8.01e-7 Blood metabolite levels; CESC cis rs11098499 0.820 rs11737395 chr4:120520704 C/G cg24375607 chr4:120327624 NA 0.46 5.53 0.32 7.85e-8 Corneal astigmatism; CESC cis rs8092503 1.000 rs6566871 chr18:52475904 T/C cg12377874 chr18:52495404 RAB27B -0.35 -5.99 -0.35 6.86e-9 Childhood body mass index; CESC cis rs7246657 0.943 rs7255996 chr19:37971699 G/A cg23950597 chr19:37808831 NA -0.58 -6.44 -0.37 5.71e-10 Coronary artery calcification; CESC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs2040771 0.745 rs2283646 chr22:19273902 A/G cg02655711 chr22:19163373 SLC25A1 -0.4 -5.87 -0.34 1.28e-8 Metabolite levels (small molecules and protein measures); CESC trans rs561341 1.000 rs113115092 chr17:30284164 G/A cg27661571 chr11:113659931 NA -0.83 -7.69 -0.43 2.82e-13 Hip circumference adjusted for BMI; CESC cis rs9815354 1.000 rs73077367 chr3:41851959 G/A cg03022575 chr3:42003672 ULK4 0.48 5.45 0.32 1.16e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs2040771 0.872 rs12485084 chr22:19162326 A/G cg17887427 chr22:19166691 SLC25A1 -0.39 -5.07 -0.3 7.63e-7 Metabolite levels (small molecules and protein measures); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12626968 chr5:43603169 NNT 0.66 7.95 0.44 5.42e-14 Gut microbiome composition (summer); CESC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.61 8.06 0.44 2.6e-14 Menopause (age at onset); CESC cis rs858239 0.600 rs6978827 chr7:23125544 A/T cg23682824 chr7:23144976 KLHL7 0.55 7.63 0.42 4.21e-13 Cerebrospinal fluid biomarker levels; CESC cis rs2070488 1.000 rs2276540 chr3:38512507 G/A cg24069376 chr3:38537580 EXOG 0.49 8.83 0.48 1.49e-16 Electrocardiographic conduction measures; CESC cis rs9467711 0.606 rs28362606 chr6:26365586 T/C cg14345882 chr6:26364793 BTN3A2 0.61 6.34 0.36 1e-9 Autism spectrum disorder or schizophrenia; CESC cis rs992157 1.000 rs2168704 chr2:219142492 G/A cg00012203 chr2:219082015 ARPC2 0.82 11.06 0.56 1.27e-23 Colorectal cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04215179 chr7:23719682 C7orf46 -0.42 -6.0 -0.35 6.59e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11785693 0.862 rs17350978 chr8:4983418 G/C cg26367366 chr8:4980734 NA 0.92 8.51 0.46 1.29e-15 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs6963495 0.818 rs56268110 chr7:105166712 T/C cg13798780 chr7:105162888 PUS7 0.78 8.02 0.44 3.36e-14 Bipolar disorder (body mass index interaction); CESC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg20307385 chr11:47447363 PSMC3 -0.6 -7.41 -0.41 1.68e-12 Subjective well-being; CESC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg04315214 chr1:2043799 PRKCZ -0.45 -7.13 -0.4 9.3e-12 Height; CESC cis rs2070677 0.736 rs7099806 chr10:135414896 C/T cg20169779 chr10:135381914 SYCE1 -0.8 -8.86 -0.48 1.23e-16 Gout; CESC cis rs9929218 0.954 rs9923925 chr16:68819444 G/A cg02972257 chr16:68554789 NA 0.46 5.55 0.32 7.01e-8 Colorectal cancer; CESC cis rs4704187 0.687 rs4704176 chr5:74420596 G/C cg03227963 chr5:74354835 NA 0.31 5.7 0.33 3.22e-8 Response to amphetamines; CESC cis rs8077577 0.789 rs11078411 chr17:18088094 C/T cg16794390 chr17:18148240 FLII 0.41 5.71 0.33 3.05e-8 Obesity-related traits; CESC cis rs561341 1.000 rs561341 chr17:30316385 T/G cg19193384 chr17:30244184 NA -0.67 -6.36 -0.36 8.74e-10 Hip circumference adjusted for BMI; CESC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.97 9.41 0.5 2.47e-18 Platelet count; CESC cis rs11122272 0.735 rs2355873 chr1:231477442 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.43 -5.74 -0.33 2.62e-8 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03385944 chr11:798041 NA 0.6 6.63 0.38 1.84e-10 Gut microbiome composition (summer); CESC cis rs9322193 1.000 rs9322193 chr6:149919143 T/G cg07701084 chr6:150067640 NUP43 0.4 5.47 0.32 1.02e-7 Lung cancer; CESC cis rs9929218 1.000 rs12443730 chr16:68804342 T/C cg02972257 chr16:68554789 NA 0.43 5.18 0.3 4.5e-7 Colorectal cancer; CESC cis rs72945132 0.714 rs66542029 chr11:70196302 A/T cg14191688 chr11:70257035 CTTN 0.41 5.05 0.3 8.16e-7 Coronary artery disease; CESC cis rs1784581 0.894 rs1790000 chr6:162388707 A/G cg17173639 chr6:162384350 PARK2 0.81 13.34 0.63 2.1e-31 Itch intensity from mosquito bite; CESC cis rs72781680 0.752 rs56343114 chr2:23900629 C/G cg08917208 chr2:24149416 ATAD2B 1.08 9.78 0.51 1.75e-19 Lymphocyte counts; CESC cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg12292205 chr6:26970375 C6orf41 -0.49 -5.44 -0.32 1.24e-7 Intelligence (multi-trait analysis); CESC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg11644478 chr21:40555479 PSMG1 -0.55 -7.49 -0.42 1.03e-12 Menarche (age at onset); CESC cis rs2273669 0.667 rs11153147 chr6:109304058 A/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.07 -0.35 4.34e-9 Prostate cancer; CESC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg05552183 chr6:42928497 GNMT 0.75 11.45 0.58 6.22e-25 Alzheimer's disease in APOE e4+ carriers; CESC cis rs75804782 0.521 rs56120037 chr2:239398464 G/A cg18131467 chr2:239335373 ASB1 -0.68 -5.66 -0.33 3.85e-8 Morning vs. evening chronotype;Chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02878701 chr21:47706221 MCM3AP;C21orf57 -0.45 -6.1 -0.35 3.78e-9 Fibrinogen levels; CESC trans rs7937682 0.924 rs12791699 chr11:111505880 T/C cg18187862 chr3:45730750 SACM1L 0.51 6.47 0.37 4.81e-10 Primary sclerosing cholangitis; CESC cis rs75804782 0.521 rs72993044 chr2:239397949 C/T cg18131467 chr2:239335373 ASB1 -0.68 -5.66 -0.33 3.85e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs11785693 0.862 rs11778367 chr8:4988398 T/C cg26367366 chr8:4980734 NA 0.61 6.23 0.36 1.85e-9 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs7116495 1.000 rs116781589 chr11:71825006 G/T cg10381502 chr11:71823885 C11orf51 0.69 5.61 0.33 5.03e-8 Severe influenza A (H1N1) infection; CESC trans rs11088226 0.645 rs2409457 chr21:33929895 T/C cg09050820 chr6:167586206 TCP10L2 0.87 8.52 0.46 1.23e-15 Gastritis; CESC trans rs354225 0.512 rs6753004 chr2:54962723 C/A cg08887902 chr7:77428575 PHTF2;TMEM60 -0.62 -6.22 -0.36 1.95e-9 Schizophrenia; CESC cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg05347473 chr6:146136440 FBXO30 -0.71 -8.55 -0.46 1.02e-15 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg06456125 chr7:65229604 NA 0.45 5.87 0.34 1.28e-8 Aortic root size; CESC cis rs7714584 1.000 rs6862814 chr5:150245259 G/A cg22134413 chr5:150180641 NA 0.5 5.76 0.33 2.3e-8 Crohn's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.12.1204902R chr12:57570411 LRP1 -0.45 -6.14 -0.35 2.94e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg11764359 chr7:65958608 NA 0.78 11.31 0.57 1.86e-24 Aortic root size; CESC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg10351095 chr21:47802916 PCNT -0.49 -6.63 -0.38 1.85e-10 Testicular germ cell tumor; CESC trans rs1973993 0.691 rs4000303 chr1:96913765 A/G cg10631902 chr5:14652156 NA 0.62 9.75 0.51 2.1e-19 Weight; CESC cis rs2073300 1.000 rs6137966 chr20:23444359 A/T cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6812193 0.518 rs6810903 chr4:77198363 C/T cg20311846 chr4:77356250 SHROOM3 0.32 5.14 0.3 5.45e-7 Parkinson's disease; CESC cis rs116095464 0.558 rs6555056 chr5:226222 T/C cg10591111 chr5:226296 SDHA -0.53 -6.61 -0.38 2.15e-10 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24099023 chr17:56770189 TEX14;RAD51C 0.62 6.91 0.39 3.53e-11 Gut microbiome composition (summer); CESC cis rs1348850 0.958 rs10497501 chr2:178462299 C/G cg23306229 chr2:178417860 TTC30B 0.57 7.52 0.42 8.3e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2295359 0.892 rs17375018 chr1:67655147 A/G cg17031739 chr1:67600172 NA -0.39 -5.29 -0.31 2.55e-7 Psoriasis; CESC cis rs3026101 0.624 rs17635627 chr17:5296059 C/T cg24500398 chr17:5266808 RABEP1 -0.42 -5.96 -0.34 8.18e-9 Body mass index; CESC cis rs2066819 1.000 rs57137641 chr12:56741228 G/A cg26714650 chr12:56694279 CS -1.39 -9.17 -0.49 1.33e-17 Psoriasis vulgaris; CESC cis rs748404 0.697 rs524547 chr15:43551023 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.96 0.44 5.16e-14 Lung cancer; CESC cis rs597583 0.715 rs2276340 chr11:117391966 G/A cg27161313 chr11:117392002 DSCAML1 -0.53 -6.25 -0.36 1.6e-9 Putamen volume; CESC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs9715521 0.835 rs9714848 chr4:59824650 C/T cg11281224 chr4:60001000 NA -0.51 -6.67 -0.38 1.45e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs300703 0.654 rs401364 chr2:119493 G/A cg21211680 chr2:198530 NA -1.03 -10.03 -0.52 2.8e-20 Blood protein levels; CESC cis rs919433 1.000 rs2889363 chr2:198163699 A/G cg03934865 chr2:198174659 NA -0.45 -6.68 -0.38 1.37e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs3733585 0.699 rs6856127 chr4:9965443 T/C cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.34e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10089 1.000 rs17164310 chr5:127493679 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 9.36 0.5 3.49e-18 Ileal carcinoids; CESC cis rs3733585 0.673 rs7672947 chr4:9961368 G/C cg00071950 chr4:10020882 SLC2A9 -0.73 -11.79 -0.59 4.58e-26 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4423214 1.000 rs4423214 chr11:71173254 C/T cg05163923 chr11:71159392 DHCR7 0.83 11.29 0.57 2.17e-24 Vitamin D levels; CESC cis rs7116495 0.867 rs612255 chr11:71778664 A/G cg07596299 chr11:71824057 C11orf51 -0.89 -5.56 -0.32 6.63e-8 Severe influenza A (H1N1) infection; CESC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg20999797 chr1:1681921 NA 0.27 5.38 0.31 1.63e-7 Body mass index; CESC cis rs9300255 0.566 rs10744150 chr12:123721614 A/C cg00376283 chr12:123451042 ABCB9 0.67 8.91 0.48 8.16e-17 Neutrophil percentage of white cells; CESC cis rs2243480 1.000 rs35046236 chr7:65408613 T/C cg12463550 chr7:65579703 CRCP 0.7 5.58 0.32 5.87e-8 Diabetic kidney disease; CESC cis rs9287719 0.967 rs6432114 chr2:10744930 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.6e-8 Prostate cancer; CESC trans rs9929218 1.000 rs8044058 chr16:68807088 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.36 -0.46 3.68e-15 Colorectal cancer; CESC cis rs2637266 0.935 rs2583053 chr10:78402416 A/G cg18941641 chr10:78392320 NA 0.45 8.65 0.47 4.9e-16 Pulmonary function; CESC cis rs3760982 0.585 rs4803659 chr19:44290235 C/T cg11993925 chr19:44307056 LYPD5 0.32 5.42 0.32 1.37e-7 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs1267303 0.675 rs7519040 chr1:46986641 A/G cg25110126 chr1:46999211 NA 0.72 8.95 0.48 6.36e-17 Monobrow; CESC cis rs67311347 0.568 rs9864544 chr3:40336204 T/C cg09455208 chr3:40491958 NA 0.37 6.51 0.37 3.82e-10 Renal cell carcinoma; CESC cis rs709400 0.691 rs12888077 chr14:103872553 G/T cg12935359 chr14:103987150 CKB 0.5 7.5 0.42 9.63e-13 Body mass index; CESC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.36 0.5 3.44e-18 Menopause (age at onset); CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.64 -0.33 4.35e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7833986 0.501 rs72653959 chr8:56996516 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.54 0.42 7.58e-13 Height; CESC cis rs8060686 0.858 rs7196789 chr16:67927124 C/T cg26727032 chr16:67993705 SLC12A4 -0.67 -10.03 -0.52 2.87e-20 HDL cholesterol;Metabolic syndrome; CESC cis rs7762018 0.891 rs12529402 chr6:170147675 A/T cg05834625 chr6:170176447 C6orf70 0.65 7.17 0.4 7.57e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6831352 0.918 rs29001199 chr4:100053891 A/G cg13256891 chr4:100009986 ADH5 -0.77 -8.34 -0.46 4.19e-15 Alcohol dependence; CESC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg04414720 chr1:150670196 GOLPH3L 0.52 6.88 0.39 4.32e-11 Melanoma; CESC trans rs801193 0.761 rs2659888 chr7:66230171 T/G cg26939375 chr7:64535504 NA 0.66 9.12 0.49 1.98e-17 Aortic root size; CESC cis rs7512552 0.839 rs1694385 chr1:150377960 G/A cg15654264 chr1:150340011 RPRD2 0.4 5.29 0.31 2.52e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs12042938 0.902 rs1094658 chr1:231773397 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.45 6.18 0.35 2.39e-9 Neuranatomic and neurocognitive phenotypes; CESC cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg05283184 chr6:79620031 NA -0.43 -6.5 -0.37 3.95e-10 Intelligence (multi-trait analysis); CESC cis rs7605827 0.930 rs2380653 chr2:15635011 C/A cg19274914 chr2:15703543 NA 0.37 6.64 0.38 1.76e-10 Educational attainment (years of education); CESC cis rs13064411 0.696 rs7610638 chr3:113139656 A/G cg18753928 chr3:113234510 CCDC52 -0.5 -5.66 -0.33 3.9e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs10883723 0.775 rs7917158 chr10:104246471 C/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.18 0.3 4.35e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs2228479 0.850 rs17233567 chr16:89813821 G/A cg00800038 chr16:89945340 TCF25 -0.9 -7.51 -0.42 9.11e-13 Skin colour saturation; CESC cis rs708547 0.830 rs1713994 chr4:57868367 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.55 -6.28 -0.36 1.39e-9 Response to bleomycin (chromatid breaks); CESC cis rs11608355 0.538 rs7305165 chr12:109804222 G/A cg19025524 chr12:109796872 NA -0.52 -7.59 -0.42 5.31e-13 Neuroticism; CESC cis rs4803468 1.000 rs2288871 chr19:41917868 C/T cg09537434 chr19:41945824 ATP5SL -1.03 -18.3 -0.75 6.46e-49 Height; CESC cis rs9649465 1.000 rs1506635 chr7:123317184 C/T cg04330084 chr7:123175371 IQUB -0.38 -5.22 -0.31 3.69e-7 Migraine; CESC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg11494091 chr17:61959527 GH2 0.73 12.49 0.61 1.88e-28 Prudent dietary pattern; CESC cis rs4795419 1 rs4795419 chr17:38166003 G/A cg17467752 chr17:38218738 THRA 0.68 10.18 0.53 9.27e-21 Monocyte percentage of white cells; CESC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg18876405 chr7:65276391 NA 0.46 6.19 0.36 2.27e-9 Aortic root size; CESC cis rs73206853 0.563 rs73194026 chr12:111140219 G/T cg12870014 chr12:110450643 ANKRD13A 0.72 6.19 0.36 2.27e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs62344088 1.000 rs56315075 chr5:103904 G/A cg22857025 chr5:266934 NA -1.08 -6.64 -0.38 1.77e-10 Asthma (childhood onset); CESC cis rs425277 0.958 rs262652 chr1:2090816 T/C cg24578937 chr1:2090814 PRKCZ 0.55 9.48 0.5 1.47e-18 Height; CESC cis rs113835537 0.559 rs11227498 chr11:66269714 A/G cg24851651 chr11:66362959 CCS 0.43 5.29 0.31 2.62e-7 Airway imaging phenotypes; CESC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg03240473 chr21:43526662 UMODL1;C21orf128 0.43 5.53 0.32 7.62e-8 IgG glycosylation; CESC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg25072359 chr17:41440525 NA 0.43 5.83 0.34 1.61e-8 Menopause (age at onset); CESC cis rs6582630 0.502 rs11520279 chr12:38360871 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.77 0.33 2.24e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.8 9.18 0.49 1.27e-17 Alzheimer's disease; CESC cis rs796364 0.906 rs6740981 chr2:201060216 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.6 6.04 0.35 5.22e-9 Schizophrenia; CESC cis rs8017423 1.000 rs8011810 chr14:90685669 A/G cg14092571 chr14:90743983 NA -0.58 -8.74 -0.47 2.81e-16 Mortality in heart failure; CESC cis rs847577 0.630 rs2132276 chr7:97826340 G/A cg21770322 chr7:97807741 LMTK2 0.86 14.66 0.67 4.82e-36 Breast cancer; CESC cis rs34779708 0.966 rs1148245 chr10:35511894 C/T cg03585969 chr10:35415529 CREM 0.73 9.06 0.49 2.99e-17 Inflammatory bowel disease;Crohn's disease; CESC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg07701084 chr6:150067640 NUP43 0.42 5.82 0.34 1.66e-8 Lung cancer; CESC cis rs926392 0.547 rs6129161 chr20:37678327 T/G cg16355469 chr20:37678765 NA 0.6 7.2 0.4 6.11e-12 Dialysis-related mortality; CESC cis rs977987 0.866 rs17696831 chr16:75493298 C/G cg03315344 chr16:75512273 CHST6 0.54 7.9 0.44 7.59e-14 Dupuytren's disease; CESC cis rs9549260 0.755 rs9549255 chr13:41235213 C/T cg21288729 chr13:41239152 FOXO1 0.66 8.58 0.47 8.21e-16 Red blood cell count; CESC cis rs7524258 0.868 rs4908451 chr1:7299618 C/G cg07173049 chr1:7289937 CAMTA1 -0.44 -6.65 -0.38 1.7e-10 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg22823121 chr1:150693482 HORMAD1 0.44 6.19 0.36 2.28e-9 Melanoma; CESC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg11890956 chr21:40555474 PSMG1 -1.04 -16.43 -0.71 2.7e-42 Cognitive function; CESC cis rs1348850 0.567 rs7605609 chr2:178534942 C/G cg23306229 chr2:178417860 TTC30B 0.54 6.46 0.37 4.91e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7312933 0.898 rs10880221 chr12:42384589 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.38 5.03 0.3 8.96e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg24324837 chr19:49891574 CCDC155 0.45 5.28 0.31 2.74e-7 Multiple sclerosis; CESC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.45 6.0 0.35 6.37e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17826219 0.500 rs2449749 chr17:29078298 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Body mass index; CESC cis rs9640161 0.711 rs3735170 chr7:150034184 T/C cg17279839 chr7:150038598 RARRES2 0.45 5.44 0.32 1.2e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs12540874 0.542 rs3807562 chr7:50566671 G/A cg18232548 chr7:50535776 DDC -0.35 -5.1 -0.3 6.58e-7 Systemic sclerosis; CESC cis rs3820068 0.580 rs12747696 chr1:16002978 A/G cg18133145 chr1:16060689 PLEKHM2 -0.41 -5.03 -0.3 8.85e-7 Systolic blood pressure; CESC cis rs9300255 0.602 rs2851438 chr12:123643689 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.86 0.48 1.16e-16 Neutrophil percentage of white cells; CESC cis rs11122272 0.637 rs2808593 chr1:231524228 G/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC trans rs681383 1.000 rs681383 chr18:8323984 A/T cg27042584 chr16:51168485 NA -0.52 -6.35 -0.36 9.28e-10 Sitting height ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06717492 chr7:65447339 GUSB 0.55 6.53 0.37 3.32e-10 Gut microbiome composition (summer); CESC trans rs7088969 0.670 rs7094126 chr10:119551326 G/A cg11827998 chr14:105995685 TMEM121 -0.42 -6.18 -0.35 2.46e-9 Homeostasis model assessment of beta-cell function (dietary factor interaction); CESC cis rs9309473 0.519 rs13027816 chr2:73897691 C/T cg20560298 chr2:73613845 ALMS1 0.53 7.32 0.41 3.04e-12 Metabolite levels; CESC cis rs3747547 0.642 rs7018920 chr9:38088018 C/T cg13774184 chr9:37916125 SHB -0.61 -5.27 -0.31 2.8e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs2243480 0.901 rs35087093 chr7:65405208 C/T cg13147721 chr7:65941812 NA -0.85 -8.1 -0.45 2e-14 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05666571 chr18:34409053 C18orf10;KIAA1328 0.65 7.64 0.42 3.98e-13 Gut microbiome composition (summer); CESC cis rs9354352 0.967 rs6455062 chr6:66694131 T/A cg07460842 chr6:66804631 NA 0.66 9.82 0.52 1.33e-19 Initial pursuit acceleration in psychotic disorders; CESC cis rs34375054 0.525 rs7133864 chr12:125606180 C/T cg25124228 chr12:125621409 AACS -0.57 -7.24 -0.41 4.91e-12 Post bronchodilator FEV1/FVC ratio; CESC cis rs66561647 0.661 rs35851359 chr8:128935626 G/C cg05480350 chr8:128972681 MIR1205;PVT1 0.38 5.14 0.3 5.39e-7 Hemoglobin concentration; CESC cis rs2425143 0.512 rs2425126 chr20:34331730 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.84 0.39 5.48e-11 Blood protein levels; CESC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg06634786 chr22:41940651 POLR3H 0.69 6.84 0.39 5.55e-11 Vitiligo; CESC cis rs7917772 0.582 rs10786685 chr10:104323103 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.44 5.46 0.32 1.1e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02847575 chr16:30382517 TBC1D10B -0.45 -6.19 -0.36 2.28e-9 Gambling; CESC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg11766577 chr21:47581405 C21orf56 -0.46 -6.36 -0.36 8.73e-10 Testicular germ cell tumor; CESC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg24829409 chr8:58192753 C8orf71 -0.65 -7.36 -0.41 2.29e-12 Developmental language disorder (linguistic errors); CESC trans rs6543990 0.766 rs1510734 chr2:36189067 C/A cg04092111 chr11:58728533 NA 0.39 6.05 0.35 4.95e-9 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16872795 chr11:111957488 SDHD;TIMM8B 0.55 6.39 0.37 7.26e-10 Gut microbiome composition (summer); CESC cis rs854765 0.964 rs854810 chr17:18006421 G/C cg16928487 chr17:17741425 SREBF1 0.57 9.57 0.51 7.75e-19 Total body bone mineral density; CESC trans rs35110281 0.774 rs2838327 chr21:45018566 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 6.31 0.36 1.15e-9 Mean corpuscular volume; CESC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg26818010 chr10:134567672 INPP5A -0.9 -11.14 -0.56 6.82e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg22535103 chr8:58192502 C8orf71 -0.93 -9.17 -0.49 1.35e-17 Developmental language disorder (linguistic errors); CESC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg08859206 chr1:53392774 SCP2 -0.62 -8.48 -0.46 1.63e-15 Monocyte count; CESC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg05368731 chr17:41323189 NBR1 0.79 11.16 0.57 5.74e-24 Menopause (age at onset); CESC cis rs113835537 0.529 rs80100524 chr11:66245936 C/T cg22134325 chr11:66188745 NPAS4 0.35 5.47 0.32 1.05e-7 Airway imaging phenotypes; CESC cis rs7193541 0.646 rs4888267 chr16:74687906 A/G cg05580060 chr16:74700937 RFWD3 -0.49 -6.3 -0.36 1.27e-9 Multiple myeloma; CESC cis rs12500482 0.935 rs12644638 chr4:2413461 C/T cg08330972 chr4:2403930 ZFYVE28 -0.37 -5.75 -0.33 2.46e-8 Cognitive function; CESC cis rs9611565 0.921 rs5751081 chr22:41742788 A/T cg06481639 chr22:41940642 POLR3H -0.45 -5.21 -0.3 3.74e-7 Vitiligo; CESC trans rs1814175 0.817 rs4881648 chr11:49812901 A/G cg03929089 chr4:120376271 NA -0.91 -15.23 -0.68 4.84e-38 Height; CESC cis rs12530845 1.000 rs12530845 chr7:135329978 T/C cg23117316 chr7:135346802 PL-5283 -0.41 -5.29 -0.31 2.52e-7 Red blood cell traits; CESC cis rs16854884 0.586 rs6795008 chr3:143738421 A/G cg06585982 chr3:143692056 C3orf58 0.51 6.92 0.39 3.46e-11 Economic and political preferences (feminism/equality); CESC cis rs4722166 0.630 rs13311155 chr7:22789789 A/C cg13104385 chr7:22767384 IL6 0.49 6.56 0.37 2.81e-10 Lung cancer; CESC cis rs7546094 1.000 rs6691932 chr1:113144263 T/C cg22162597 chr1:113214053 CAPZA1 0.39 5.95 0.34 8.37e-9 Platelet distribution width; CESC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg18876405 chr7:65276391 NA 0.44 6.06 0.35 4.76e-9 Aortic root size; CESC trans rs656319 0.638 rs670044 chr8:9892529 G/T cg06636001 chr8:8085503 FLJ10661 0.5 6.58 0.37 2.47e-10 Myopia (pathological); CESC cis rs2276314 0.857 rs28379448 chr18:33604364 C/A cg05985134 chr18:33552581 C18orf21 0.61 7.07 0.4 1.39e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs6921919 0.583 rs7764722 chr6:28354533 C/T cg21251018 chr6:28226885 NKAPL 0.35 6.06 0.35 4.75e-9 Autism spectrum disorder or schizophrenia; CESC cis rs4648845 0.579 rs4592207 chr1:2369498 A/G cg02275930 chr1:2372054 NA -0.36 -5.79 -0.34 1.98e-8 Schizophrenia; CESC cis rs3859192 0.539 rs2302774 chr17:38183090 G/T cg17344932 chr17:38183730 MED24;SNORD124 0.63 9.39 0.5 2.83e-18 White blood cell count; CESC cis rs1808579 0.935 rs58609749 chr18:21108613 T/C cg14672496 chr18:21087552 C18orf8 0.4 6.09 0.35 4e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg26335602 chr6:28129616 ZNF389 0.48 6.14 0.35 3.05e-9 Parkinson's disease; CESC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg03709012 chr19:19516395 GATAD2A -0.99 -15.52 -0.69 4.48e-39 Tonsillectomy; CESC cis rs959260 0.528 rs9909443 chr17:73308346 C/T cg14668889 chr17:73230827 NUP85 0.57 6.7 0.38 1.22e-10 Systemic lupus erythematosus; CESC cis rs9287719 0.967 rs6706542 chr2:10742491 A/C cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg11644478 chr21:40555479 PSMG1 -0.84 -12.87 -0.62 9.03e-30 Cognitive function; CESC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.3 0.63 2.94e-31 Prudent dietary pattern; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24306779 chr16:58060336 MMP15 0.47 6.07 0.35 4.38e-9 Gut microbiota (bacterial taxa); CESC cis rs4253772 0.530 rs9615980 chr22:46791143 A/T cg18190219 chr22:46762943 CELSR1 -0.66 -6.08 -0.35 4.18e-9 LDL cholesterol;Cholesterol, total; CESC cis rs7582720 1.000 rs72936881 chr2:203794262 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs34779708 0.897 rs7897827 chr10:35386237 C/T cg03585969 chr10:35415529 CREM 0.78 10.4 0.54 1.78e-21 Inflammatory bowel disease;Crohn's disease; CESC trans rs561341 0.654 rs6505265 chr17:30172580 C/T cg20587970 chr11:113659929 NA 0.92 9.74 0.51 2.4e-19 Hip circumference adjusted for BMI; CESC cis rs6736093 0.966 rs1122970 chr2:112716697 A/C cg12686935 chr2:112915763 FBLN7 -0.41 -5.31 -0.31 2.29e-7 Coronary artery disease; CESC cis rs3540 0.597 rs7498113 chr15:91051192 C/G cg10434728 chr15:90938212 IQGAP1 -0.41 -7.26 -0.41 4.23e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.07 0.53 2.09e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs644799 0.544 rs555556 chr11:95618425 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.55 7.12 0.4 1.02e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14264489 chr6:43018788 CUL7 -0.61 -6.5 -0.37 3.99e-10 Gut microbiome composition (summer); CESC cis rs1506636 0.962 rs17623873 chr7:123417100 C/A cg03229431 chr7:123269106 ASB15 0.5 6.39 0.37 7.27e-10 Plateletcrit;Platelet count; CESC cis rs2204008 0.774 rs7959048 chr12:37948276 T/A cg13010199 chr12:38710504 ALG10B 0.5 6.42 0.37 6.42e-10 Bladder cancer; CESC cis rs11148252 0.574 rs3742297 chr13:53278067 T/C cg00495681 chr13:53174319 NA 0.62 8.56 0.47 9.42e-16 Lewy body disease; CESC cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg21573476 chr21:45109991 RRP1B -0.49 -6.96 -0.39 2.7e-11 Mean corpuscular volume; CESC cis rs78456975 0.527 rs7590743 chr2:1575048 A/G cg26248373 chr2:1572462 NA -0.59 -6.93 -0.39 3.22e-11 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4974559 0.739 rs10032327 chr4:1323537 C/T cg02980000 chr4:1222292 CTBP1 0.82 7.38 0.41 2.05e-12 Systolic blood pressure; CESC cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.75 0.62 2.34e-29 Colonoscopy-negative controls vs population controls; CESC cis rs965513 1.000 rs4743131 chr9:100554907 C/G cg13688889 chr9:100608707 NA -0.58 -8.26 -0.45 6.88e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs4268898 0.552 rs7560342 chr2:24371691 T/C cg06627628 chr2:24431161 ITSN2 0.6 8.31 0.45 5.17e-15 Asthma; CESC cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg05283184 chr6:79620031 NA -0.43 -6.56 -0.37 2.88e-10 Intelligence (multi-trait analysis); CESC cis rs7662987 0.517 rs2602845 chr4:100023944 T/C cg12011299 chr4:100065546 ADH4 0.6 6.6 0.38 2.23e-10 Smoking initiation; CESC cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.25 0.31 3.18e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs3820928 1.000 rs11686072 chr2:227777493 A/T cg11843606 chr2:227700838 RHBDD1 -0.43 -5.81 -0.34 1.74e-8 Pulmonary function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06697471 chr10:133606998 NA -0.4 -6.53 -0.37 3.26e-10 Gut microbiome composition (summer); CESC cis rs12142240 0.698 rs67142569 chr1:46828460 C/T cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.12e-9 Menopause (age at onset); CESC cis rs708547 0.914 rs2412760 chr4:57735192 A/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.53 5.33 0.31 2.11e-7 Response to bleomycin (chromatid breaks); CESC cis rs9487051 0.646 rs7773490 chr6:109623048 T/C cg01475377 chr6:109611718 NA -0.4 -5.48 -0.32 9.91e-8 Reticulocyte fraction of red cells; CESC cis rs7909074 1.000 rs10751360 chr10:45396971 G/A cg05187965 chr10:45406764 TMEM72 -0.33 -5.1 -0.3 6.34e-7 Mean corpuscular volume; CESC cis rs9457247 0.765 rs12212247 chr6:167413539 T/C cg07741184 chr6:167504864 NA 0.34 6.23 0.36 1.78e-9 Crohn's disease; CESC cis rs7223966 0.961 rs35844156 chr17:61837568 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.08 -0.3 6.98e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7666738 0.830 rs1813251 chr4:98921170 A/G cg05340658 chr4:99064831 C4orf37 0.78 11.59 0.58 2.05e-25 Colonoscopy-negative controls vs population controls; CESC cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.9 13.31 0.63 2.68e-31 Platelet count; CESC cis rs6460942 0.597 rs6944517 chr7:12515283 C/T cg20607287 chr7:12443886 VWDE -0.63 -7.11 -0.4 1.1e-11 Coronary artery disease; CESC cis rs7917772 0.560 rs3862030 chr10:104327584 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.61 0.33 5.05e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9790314 1.000 rs2218803 chr3:161047973 T/G cg03342759 chr3:160939853 NMD3 -0.45 -5.81 -0.34 1.77e-8 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg18180107 chr4:99064573 C4orf37 0.39 5.07 0.3 7.39e-7 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07146723 chr14:21559356 ZNF219 0.49 6.55 0.37 3.05e-10 Fibrinogen levels; CESC cis rs9487051 0.604 rs9320282 chr6:109619377 A/G cg21918786 chr6:109611834 NA -0.38 -5.46 -0.32 1.11e-7 Reticulocyte fraction of red cells; CESC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg18337363 chr3:52569053 NT5DC2 0.28 5.09 0.3 6.67e-7 Bipolar disorder; CESC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.49 0.37 4.1e-10 Bipolar disorder; CESC cis rs12464483 0.591 rs72800120 chr2:30897122 G/A cg12454169 chr2:30669597 LCLAT1 0.6 6.16 0.35 2.71e-9 Pre-treatment pain in head and neck squamous cell carcinoma; CESC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg00908189 chr16:619842 PIGQ 0.64 8.99 0.48 4.97e-17 Height; CESC cis rs7208859 0.673 rs216435 chr17:28922737 G/T cg19761014 chr17:28927070 LRRC37B2 0.8 7.35 0.41 2.52e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8008758 0.963 rs10132271 chr14:101688874 C/T cg26224664 chr14:101693935 NA -0.36 -5.62 -0.33 4.96e-8 Body mass index (alcohol intake interaction); CESC cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs12586317 0.620 rs12437439 chr14:35585669 C/A cg16230307 chr14:35515116 FAM177A1 0.96 10.33 0.54 2.95e-21 Psoriasis; CESC cis rs7651039 0.619 rs7640807 chr3:15685137 A/G cg16303742 chr3:15540471 COLQ 0.47 7.48 0.42 1.08e-12 Coronary heart disease; CESC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg26335602 chr6:28129616 ZNF389 0.53 7.05 0.4 1.55e-11 Parkinson's disease; CESC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg06221963 chr1:154839813 KCNN3 -0.66 -11.32 -0.57 1.71e-24 Prostate cancer; CESC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg00166722 chr3:10149974 C3orf24 0.49 5.98 0.34 7.37e-9 Alzheimer's disease; CESC cis rs708547 0.647 rs1718831 chr4:57886946 T/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.48 6.68 0.38 1.38e-10 Response to bleomycin (chromatid breaks); CESC cis rs826838 0.967 rs11168985 chr12:39045983 A/C cg13010199 chr12:38710504 ALG10B -0.56 -7.64 -0.42 3.99e-13 Heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15197342 chr1:110950013 HBXIP 0.59 6.78 0.38 7.7e-11 Gut microbiome composition (summer); CESC cis rs2735413 0.918 rs7197254 chr16:78063353 C/G cg04733911 chr16:78082701 NA -0.48 -7.56 -0.42 6.42e-13 Systolic blood pressure (alcohol consumption interaction); CESC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg18446336 chr7:2847575 GNA12 -0.37 -5.5 -0.32 8.96e-8 Height; CESC cis rs1005277 0.522 rs289648 chr10:37971837 T/C cg00409905 chr10:38381863 ZNF37A -0.46 -6.31 -0.36 1.17e-9 Extrinsic epigenetic age acceleration; CESC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg05340658 chr4:99064831 C4orf37 0.84 13.17 0.63 8.25e-31 Colonoscopy-negative controls vs population controls; CESC cis rs6446731 0.593 rs6446726 chr4:3274214 T/C cg08886695 chr4:3369023 RGS12 -0.39 -5.62 -0.33 4.82e-8 Mean platelet volume; CESC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg18876405 chr7:65276391 NA 0.48 6.0 0.35 6.34e-9 Aortic root size; CESC cis rs5769765 1.000 rs2295408 chr22:50261051 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.28 0.31 2.69e-7 Schizophrenia; CESC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg18876405 chr7:65276391 NA 0.72 10.02 0.52 2.97e-20 Aortic root size; CESC cis rs6977660 0.562 rs2189566 chr7:19768960 G/A cg07541023 chr7:19748670 TWISTNB 0.77 7.2 0.4 6.39e-12 Thyroid stimulating hormone; CESC trans rs800888 0.772 rs3808460 chr8:116597635 A/G cg19047077 chr12:105044897 CHST11 -0.46 -6.04 -0.35 5.11e-9 Monocyte percentage of white cells; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22218536 chr3:40518595 ZNF619 -0.52 -6.52 -0.37 3.52e-10 Ulcerative colitis; CESC cis rs9902453 0.934 rs7213902 chr17:28322935 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 7.92 0.44 6.76e-14 Coffee consumption (cups per day); CESC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10465746 0.780 rs10874424 chr1:84424033 C/T cg10977910 chr1:84465055 TTLL7 0.52 7.07 0.4 1.35e-11 Obesity-related traits; CESC cis rs7914558 0.966 rs4532960 chr10:104667406 C/T cg04362960 chr10:104952993 NT5C2 0.43 5.57 0.32 6.11e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11238366 chr2:38830691 HNRPLL -0.52 -6.11 -0.35 3.49e-9 Gut microbiome composition (summer); CESC cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg22875332 chr1:76189707 ACADM 0.63 6.33 0.36 1.03e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.63 0.47 5.81e-16 Electroencephalogram traits; CESC cis rs9911578 0.967 rs4076229 chr17:56937256 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -6.92 -0.39 3.44e-11 Intelligence (multi-trait analysis); CESC trans rs2121875 0.667 rs4637558 chr5:44224783 G/A cg07292773 chr6:156718177 NA -0.48 -6.08 -0.35 4.11e-9 Prostate cancer; CESC cis rs57221529 0.709 rs4957056 chr5:570105 T/C cg16447950 chr5:562315 NA -0.66 -7.0 -0.39 2.12e-11 Lung disease severity in cystic fibrosis; CESC cis rs4253772 0.591 rs6007747 chr22:46657261 A/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.49 5.16 0.3 4.91e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg18402987 chr7:1209562 NA 0.76 7.56 0.42 6.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC trans rs4671386 0.901 rs6545797 chr2:60520885 T/C cg24386296 chr4:1723849 TMEM129;TACC3 0.49 6.17 0.35 2.54e-9 Acne (severe); CESC cis rs7582720 1.000 rs72928620 chr2:203840973 G/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.83 7.26 0.41 4.31e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs7819412 0.715 rs2409727 chr8:11043236 C/T cg06636001 chr8:8085503 FLJ10661 -0.61 -7.77 -0.43 1.74e-13 Triglycerides; CESC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.55 -6.98 -0.39 2.36e-11 Prudent dietary pattern; CESC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9488822 0.596 rs13192549 chr6:116338352 C/A cg26893134 chr6:116381904 FRK 0.22 5.22 0.31 3.63e-7 Cholesterol, total;LDL cholesterol; CESC cis rs1545257 0.550 rs66943245 chr2:24631075 G/A cg06627628 chr2:24431161 ITSN2 -0.45 -5.3 -0.31 2.5e-7 Sjögren's syndrome; CESC cis rs1728785 1.000 rs1728764 chr16:68572292 G/C cg02972257 chr16:68554789 NA -0.55 -6.34 -0.36 9.7e-10 Ulcerative colitis; CESC cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg17143192 chr8:8559678 CLDN23 0.78 8.81 0.48 1.63e-16 Obesity-related traits; CESC cis rs16854884 0.657 rs1025984 chr3:143756187 C/G cg06585982 chr3:143692056 C3orf58 -0.43 -5.93 -0.34 9.39e-9 Economic and political preferences (feminism/equality); CESC trans rs3780486 0.801 rs6476398 chr9:33119241 C/T cg04842962 chr6:43655489 MRPS18A 0.99 18.06 0.74 4.6e-48 IgG glycosylation; CESC trans rs875971 0.543 rs801191 chr7:66032955 G/A cg26939375 chr7:64535504 NA -0.53 -7.31 -0.41 3.22e-12 Aortic root size; CESC cis rs933688 1.000 rs2367353 chr5:90686568 G/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.11 15.95 0.7 1.34e-40 Smoking behavior; CESC cis rs9911578 1.000 rs9892062 chr17:56976981 G/A cg12560992 chr17:57184187 TRIM37 0.93 15.26 0.68 3.55e-38 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13174343 chr10:51767556 AGAP6 -0.52 -6.69 -0.38 1.35e-10 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg00745463 chr17:30367425 LRRC37B -0.6 -5.82 -0.34 1.72e-8 Hip circumference adjusted for BMI; CESC cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg17366294 chr4:99064904 C4orf37 0.59 8.45 0.46 1.9e-15 Colonoscopy-negative controls vs population controls; CESC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg26343298 chr8:95960752 TP53INP1 0.32 5.25 0.31 3.06e-7 Type 2 diabetes; CESC cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg02487422 chr3:49467188 NICN1 0.46 5.81 0.34 1.75e-8 Parkinson's disease; CESC cis rs9457247 0.663 rs9457258 chr6:167444254 T/C cg23791538 chr6:167370224 RNASET2 -0.57 -7.7 -0.43 2.7e-13 Crohn's disease; CESC cis rs11711311 0.955 rs7617313 chr3:113391740 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.66 8.62 0.47 6.11e-16 IgG glycosylation; CESC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 -1.13 -12.6 -0.61 7.67e-29 Platelet count; CESC cis rs6696846 0.765 rs3738155 chr1:205074424 C/T cg00857998 chr1:205179979 DSTYK 0.55 7.19 0.4 6.58e-12 Red blood cell count; CESC cis rs478304 0.934 rs669742 chr11:65501291 C/T cg08755490 chr11:65554678 OVOL1 0.47 6.21 0.36 2.06e-9 Acne (severe); CESC cis rs7953508 0.506 rs10859532 chr12:93960917 G/C cg18151635 chr12:93972918 NA -0.45 -5.99 -0.35 7e-9 Pubertal anthropometrics; CESC cis rs9287719 0.967 rs4470306 chr2:10743998 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.82 -0.34 1.71e-8 Prostate cancer; CESC cis rs1707322 1.000 rs12077546 chr1:46431806 C/T cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11098499 0.542 rs10440343 chr4:120309787 G/C cg09307838 chr4:120376055 NA 0.92 12.66 0.61 4.96e-29 Corneal astigmatism; CESC cis rs9926296 0.632 rs72807526 chr16:89775946 A/G cg04287289 chr16:89883240 FANCA -0.64 -8.61 -0.47 6.55e-16 Vitiligo; CESC cis rs9858542 0.951 rs1800668 chr3:49395757 G/A cg07274523 chr3:49395745 GPX1 0.66 8.22 0.45 8.84e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs10771431 0.935 rs1117735 chr12:9372728 G/A cg08997352 chr12:9597637 DDX12 -0.68 -9.07 -0.49 2.75e-17 Breast size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15273368 chr10:104221031 TMEM180 0.57 6.61 0.38 2.11e-10 Gut microbiome composition (summer); CESC cis rs7937682 0.575 rs7950926 chr11:111776437 G/C cg22437258 chr11:111473054 SIK2 -0.52 -6.18 -0.35 2.42e-9 Primary sclerosing cholangitis; CESC cis rs1546924 0.692 rs197379 chr1:112292303 T/C cg23955903 chr1:112298873 DDX20;C1orf183 0.42 5.46 0.32 1.08e-7 Body mass index; CESC cis rs3806843 0.801 rs2531358 chr5:140117437 A/G cg16179182 chr5:140090404 VTRNA1-1 0.41 5.34 0.31 1.97e-7 Depressive symptoms (multi-trait analysis); CESC trans rs1814175 0.645 rs1851857 chr11:49855589 A/C cg03929089 chr4:120376271 NA -0.9 -14.42 -0.66 3.37e-35 Height; CESC cis rs801193 0.548 rs2659904 chr7:66178602 C/A cg18876405 chr7:65276391 NA 0.44 5.84 0.34 1.5e-8 Aortic root size; CESC cis rs11871801 0.517 rs10454087 chr17:40735641 C/T cg21433558 chr17:40837037 CNTNAP1 0.48 5.85 0.34 1.45e-8 Crohn's disease; CESC cis rs2857078 0.772 rs2079008 chr17:42322132 C/A cg08499158 chr17:42289980 UBTF 0.46 5.59 0.32 5.59e-8 Red cell distribution width;Reticulocyte count; CESC cis rs7208859 0.673 rs11080138 chr17:29224542 A/G cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12928939 0.517 rs71384782 chr16:71978591 A/G cg03805757 chr16:71968109 PKD1L3 -0.57 -6.46 -0.37 5.1e-10 Post bronchodilator FEV1; CESC cis rs9486719 1.000 rs2472886 chr6:96864876 C/T cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg23758822 chr17:41437982 NA 1.05 15.68 0.69 1.15e-39 Menopause (age at onset); CESC cis rs2228479 0.702 rs2074963 chr16:89877269 T/C cg14709524 chr16:89940631 TCF25 0.85 5.92 0.34 1.01e-8 Skin colour saturation; CESC cis rs5758659 0.714 rs6002607 chr22:42496506 C/T cg15557168 chr22:42548783 NA 0.49 7.61 0.42 4.91e-13 Cognitive function; CESC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg04369109 chr6:150039330 LATS1 -0.42 -5.91 -0.34 1.07e-8 Lung cancer; CESC cis rs7589728 0.844 rs77144652 chr2:88496684 G/A cg04511125 chr2:88470314 THNSL2 0.55 5.24 0.31 3.21e-7 Plasma clusterin levels; CESC trans rs10411161 0.752 rs10402107 chr19:52384600 A/G cg22319618 chr22:45562946 NUP50 -0.71 -7.04 -0.4 1.66e-11 Breast cancer; CESC cis rs3008870 0.755 rs2815380 chr1:67510857 A/G cg02640540 chr1:67518911 SLC35D1 -0.66 -8.6 -0.47 7.24e-16 Lymphocyte percentage of white cells; CESC cis rs9355610 0.609 rs3756838 chr6:167371251 G/A cg23791538 chr6:167370224 RNASET2 0.5 5.84 0.34 1.51e-8 Graves' disease; CESC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 4.07e-12 Major depressive disorder; CESC cis rs17826219 0.568 rs9903854 chr17:29153998 C/T cg19761014 chr17:28927070 LRRC37B2 0.72 5.91 0.34 1.03e-8 Body mass index; CESC cis rs12545109 0.800 rs990301 chr8:57406021 G/C cg09654669 chr8:57350985 NA -0.48 -6.63 -0.38 1.87e-10 Obesity-related traits; CESC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg06481639 chr22:41940642 POLR3H -0.69 -6.85 -0.39 5.18e-11 Vitiligo; CESC cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.1 0.3 6.37e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10078 0.528 rs2434697 chr5:466811 T/C cg08916839 chr5:415575 AHRR 0.58 6.72 0.38 1.1e-10 Fat distribution (HIV); CESC cis rs2066819 1.000 rs117683816 chr12:56638267 T/C cg26734620 chr12:56694298 CS 1.04 6.73 0.38 1.06e-10 Psoriasis vulgaris; CESC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.73 0.43 2.23e-13 Prudent dietary pattern; CESC cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.2e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05971751 chr4:39699140 UBE2K -0.54 -6.29 -0.36 1.33e-9 Gut microbiome composition (summer); CESC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg14926445 chr8:58193284 C8orf71 -0.52 -5.59 -0.32 5.77e-8 Developmental language disorder (linguistic errors); CESC cis rs34779708 0.771 rs12098283 chr10:35478115 G/T cg04310649 chr10:35416472 CREM -0.49 -5.74 -0.33 2.58e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs12142240 0.659 rs72677602 chr1:46837487 G/A cg10495392 chr1:46806563 NSUN4 0.58 6.02 0.35 5.95e-9 Menopause (age at onset); CESC cis rs2439831 1.000 rs7173487 chr15:43750239 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.81 10.22 0.53 6.88e-21 Lung cancer in ever smokers; CESC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -7.09 -0.4 1.2e-11 Bipolar disorder and schizophrenia; CESC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg19717773 chr7:2847554 GNA12 -0.48 -7.01 -0.4 1.97e-11 Height; CESC cis rs748404 0.697 rs492743 chr15:43560945 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.71 0.43 2.46e-13 Lung cancer; CESC cis rs1048238 0.818 rs945421 chr1:16345393 T/C cg22431228 chr1:16359049 CLCNKA -0.55 -10.9 -0.56 4.13e-23 Systolic blood pressure; CESC cis rs1707322 0.717 rs2275086 chr1:46085879 C/G cg06784218 chr1:46089804 CCDC17 -0.4 -6.85 -0.39 5.21e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg15664640 chr17:80829946 TBCD 0.4 5.73 0.33 2.69e-8 Breast cancer; CESC cis rs8020095 0.528 rs8013943 chr14:67383335 T/C cg19548862 chr14:67692701 FAM71D -0.49 -5.94 -0.34 8.86e-9 Depression (quantitative trait); CESC trans rs324780 0.544 rs3110202 chr12:83890080 C/G cg22140261 chr22:42466895 NAGA 0.47 6.04 0.35 5.24e-9 Vertical cup-disc ratio; CESC cis rs7258465 1.000 rs2007981 chr19:18567555 C/A cg25828334 chr19:18545568 ISYNA1 -0.32 -5.22 -0.31 3.63e-7 Breast cancer; CESC cis rs10242455 0.867 rs2687086 chr7:99295450 C/T cg07715041 chr7:99302981 CYP3A7 -0.44 -5.56 -0.32 6.73e-8 Blood metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26724186 chr19:3676340 PIP5K1C 0.43 6.02 0.35 5.88e-9 Fibrinogen levels; CESC cis rs6426558 0.524 rs2813948 chr1:227459621 A/T cg10327440 chr1:227177885 CDC42BPA 0.49 6.09 0.35 4.02e-9 Neutrophil percentage of white cells; CESC cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg04455712 chr21:45112962 RRP1B -0.48 -7.97 -0.44 4.69e-14 Mean corpuscular volume; CESC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg24675658 chr1:53192096 ZYG11B 0.63 8.7 0.47 3.6e-16 Monocyte count; CESC cis rs1577917 0.771 rs4419647 chr6:86225739 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.57 7.92 0.44 6.7e-14 Response to antipsychotic treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12848118 chr14:89626305 FOXN3 -0.59 -6.99 -0.39 2.27e-11 Gut microbiome composition (summer); CESC cis rs11190604 1.000 rs10883492 chr10:102206089 G/A cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg05552183 chr6:42928497 GNMT 0.76 11.53 0.58 3.3e-25 Alzheimer's disease in APOE e4+ carriers; CESC cis rs62229266 0.839 rs11702763 chr21:37470704 A/G cg12218747 chr21:37451666 NA -0.49 -6.61 -0.38 2.13e-10 Mitral valve prolapse; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18501264 chr19:33555827 RHPN2 0.65 7.33 0.41 2.8e-12 Gut microbiome composition (summer); CESC cis rs11098499 0.754 rs7689729 chr4:120256192 A/G cg09307838 chr4:120376055 NA 0.8 10.88 0.56 5.04e-23 Corneal astigmatism; CESC trans rs11722228 0.549 rs41268389 chr4:10099277 G/A cg26043149 chr18:55253948 FECH 0.92 10.95 0.56 2.93e-23 Gout;Urate levels;Serum uric acid levels; CESC cis rs10751667 0.643 rs7479473 chr11:929111 C/T cg06064525 chr11:970664 AP2A2 -0.52 -10.25 -0.53 5.74e-21 Alzheimer's disease (late onset); CESC cis rs929354 0.772 rs6459737 chr7:156975136 G/A cg05182265 chr7:156933206 UBE3C -0.51 -7.48 -0.42 1.11e-12 Body mass index; CESC cis rs10885582 0.754 rs10787533 chr10:116288063 A/T cg17056676 chr10:116301354 ABLIM1 0.29 5.14 0.3 5.22e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs6088580 0.634 rs1205334 chr20:32930369 T/C cg08999081 chr20:33150536 PIGU -0.65 -11.36 -0.57 1.3e-24 Glomerular filtration rate (creatinine); CESC cis rs113835537 0.529 rs10501397 chr11:66272976 G/T cg24851651 chr11:66362959 CCS 0.41 5.11 0.3 6.21e-7 Airway imaging phenotypes; CESC cis rs9300255 0.537 rs1727334 chr12:123714236 A/G cg05973401 chr12:123451056 ABCB9 0.5 5.58 0.32 5.95e-8 Neutrophil percentage of white cells; CESC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg22920501 chr2:26401640 FAM59B -0.87 -10.22 -0.53 6.67e-21 Gut microbiome composition (summer); CESC cis rs11122272 0.735 rs2790882 chr1:231532783 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.55 7.51 0.42 9.13e-13 Hemoglobin concentration; CESC cis rs1707322 0.691 rs12031182 chr1:46220999 C/T cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg22834771 chr12:69754056 YEATS4 -0.48 -6.37 -0.36 8.31e-10 Blood protein levels; CESC cis rs791888 0.698 rs7893652 chr10:89431060 A/G cg13926569 chr10:89418898 PAPSS2 -0.52 -7.56 -0.42 6.76e-13 Magnesium levels; CESC cis rs72781680 0.821 rs72796325 chr2:24134537 G/A cg08917208 chr2:24149416 ATAD2B 0.57 5.62 0.33 4.79e-8 Lymphocyte counts; CESC cis rs344364 0.511 rs911391 chr16:1947016 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.78e-17 Tonsillectomy; CESC trans rs983392 0.805 rs7933805 chr11:59967526 A/G cg02363969 chr19:56048075 SBK2 0.41 6.07 0.35 4.3e-9 Alzheimer's disease (late onset); CESC cis rs1670533 0.769 rs6814833 chr4:1057679 A/C cg27284194 chr4:1044797 NA 0.48 6.06 0.35 4.7e-9 Recombination rate (females); CESC cis rs2236918 1.000 rs1635512 chr1:242024500 A/G cg17736920 chr1:242011382 EXO1 -0.69 -9.29 -0.5 5.93e-18 Menopause (age at onset); CESC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg11301795 chr4:187892539 NA 0.68 10.35 0.54 2.63e-21 Lobe attachment (rater-scored or self-reported); CESC cis rs1538970 0.924 rs10890327 chr1:45891458 C/T cg03146154 chr1:46216737 IPP 0.44 5.09 0.3 6.74e-7 Platelet count; CESC cis rs10197940 0.624 rs10497082 chr2:152355258 T/C cg06191203 chr2:152266755 RIF1 -0.45 -5.2 -0.3 4e-7 Lung cancer; CESC cis rs66887589 0.777 rs1814815 chr4:120258091 C/T cg09307838 chr4:120376055 NA 0.55 7.47 0.42 1.14e-12 Diastolic blood pressure; CESC cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg11812906 chr14:75593930 NEK9 0.64 9.49 0.5 1.45e-18 Coronary artery disease; CESC cis rs9467160 1.000 rs9295624 chr6:24439600 A/G cg20631270 chr6:24437470 GPLD1 -0.43 -5.18 -0.3 4.48e-7 Liver enzyme levels; CESC cis rs1198430 0.852 rs909537 chr1:23810063 C/G cg22040403 chr1:23858016 E2F2 0.67 5.4 0.31 1.47e-7 Total cholesterol levels; CESC cis rs858239 0.601 rs10263110 chr7:23160551 G/A cg23682824 chr7:23144976 KLHL7 0.54 7.38 0.41 2.09e-12 Cerebrospinal fluid biomarker levels; CESC cis rs7086627 0.515 rs4934189 chr10:82214792 C/T cg03267442 chr10:82210566 NA -0.33 -5.43 -0.32 1.27e-7 Post bronchodilator FEV1; CESC cis rs4595586 0.545 rs12828790 chr12:39401043 G/A cg26384229 chr12:38710491 ALG10B 0.61 8.69 0.47 3.92e-16 Morning vs. evening chronotype; CESC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg12463550 chr7:65579703 CRCP -0.54 -6.96 -0.39 2.66e-11 Aortic root size; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg03342113 chr11:61197477 CPSF7;SDHAF2 0.44 6.06 0.35 4.66e-9 Bronchopulmonary dysplasia; CESC trans rs11098499 0.909 rs10014719 chr4:120320715 G/A cg25214090 chr10:38739885 LOC399744 0.72 9.92 0.52 6.25e-20 Corneal astigmatism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07611531 chr2:54853149 SPTBN1 0.47 6.56 0.37 2.81e-10 Fibrinogen levels; CESC cis rs16948098 1 rs16948098 chr15:44219607 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.77 5.5 0.32 9.09e-8 Serum albumin level; CESC cis rs6448317 0.954 rs7666033 chr4:24925272 A/G cg21108841 chr4:24914750 CCDC149 -0.47 -5.89 -0.34 1.14e-8 Heschl's gyrus morphology; CESC cis rs208520 0.690 rs12198297 chr6:66714665 G/A cg07460842 chr6:66804631 NA 0.97 13.03 0.62 2.61e-30 Exhaled nitric oxide output; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07736927 chr7:56171097 CHCHD2 0.51 6.89 0.39 3.97e-11 Fibrinogen levels; CESC cis rs5750830 0.594 rs5757648 chr22:39775156 G/A cg05872129 chr22:39784769 NA -0.75 -10.71 -0.55 1.76e-22 Intelligence (multi-trait analysis); CESC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg10691866 chr7:65817282 TPST1 0.34 5.76 0.33 2.32e-8 Aortic root size; CESC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg19717773 chr7:2847554 GNA12 -0.55 -7.85 -0.43 1.05e-13 Height; CESC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg25767906 chr1:53392781 SCP2 -0.49 -6.26 -0.36 1.55e-9 Monocyte count; CESC cis rs7107174 1.000 rs2511170 chr11:77980582 A/G cg02023728 chr11:77925099 USP35 0.45 6.55 0.37 3.01e-10 Testicular germ cell tumor; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg08575399 chr20:60719638 PSMA7;SS18L1 -0.44 -6.43 -0.37 5.94e-10 Vertical cup-disc ratio; CESC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg17724175 chr1:150552817 MCL1 0.33 5.08 0.3 7.16e-7 Tonsillectomy; CESC cis rs6460942 0.915 rs10267801 chr7:12451931 G/A cg06484146 chr7:12443880 VWDE -0.67 -8.8 -0.48 1.86e-16 Coronary artery disease; CESC cis rs6933660 0.744 rs3800279 chr6:151766162 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.47 5.42 0.32 1.33e-7 Menarche (age at onset); CESC cis rs3796352 1.000 rs75217232 chr3:53132373 A/C cg12962167 chr3:53033115 SFMBT1 0.54 5.13 0.3 5.5e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg02574844 chr11:5959923 NA -0.47 -7.33 -0.41 2.86e-12 DNA methylation (variation); CESC cis rs10504229 0.817 rs58957714 chr8:58195864 G/A cg05313129 chr8:58192883 C8orf71 -0.56 -5.57 -0.32 6.13e-8 Developmental language disorder (linguistic errors); CESC trans rs561341 1.000 rs1681718 chr17:30296445 G/A cg20587970 chr11:113659929 NA -1.43 -18.65 -0.75 3.85e-50 Hip circumference adjusted for BMI; CESC trans rs1814175 0.534 rs1983448 chr11:49933856 C/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.44 -0.75 2.03e-49 Height; CESC cis rs11677370 0.603 rs11696104 chr2:3849512 C/G cg17052675 chr2:3827356 NA -0.42 -5.46 -0.32 1.08e-7 Type 2 diabetes; CESC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 10.5 0.54 8.5e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs35146811 0.735 rs1636978 chr7:99813912 G/A cg13215871 chr17:75784724 NA -0.35 -6.39 -0.37 7.48e-10 Coronary artery disease; CESC cis rs2070433 0.752 rs11701058 chr21:47776382 T/C cg12379764 chr21:47803548 PCNT 0.67 7.44 0.42 1.38e-12 Lymphocyte counts; CESC cis rs6582630 0.502 rs4559747 chr12:38436235 G/A cg26384229 chr12:38710491 ALG10B 0.64 9.78 0.51 1.76e-19 Drug-induced liver injury (flucloxacillin); CESC cis rs1707322 0.686 rs1250 chr1:46094027 A/G cg03146154 chr1:46216737 IPP 0.78 10.84 0.55 6.67e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9902453 1.000 rs6505158 chr17:28403348 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.63 -8.05 -0.44 2.78e-14 Coffee consumption (cups per day); CESC cis rs12477438 0.501 rs11683188 chr2:99724512 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 12.81 0.62 1.43e-29 Chronic sinus infection; CESC cis rs9796 0.804 rs28688742 chr15:41403638 G/A cg20272979 chr15:41787780 ITPKA 0.37 5.62 0.33 4.95e-8 Menopause (age at onset); CESC cis rs123509 0.687 rs6865 chr3:42826041 A/C cg12982090 chr3:42733453 KBTBD5 -0.65 -7.47 -0.42 1.15e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg12963246 chr6:28129442 ZNF389 0.49 6.39 0.37 7.29e-10 Parkinson's disease; CESC cis rs965469 0.948 rs6051769 chr20:3326438 G/A cg17110299 chr20:3385021 C20orf194 0.41 5.04 0.3 8.61e-7 IFN-related cytopenia; CESC cis rs863345 0.604 rs11264983 chr1:158462218 A/C cg12129480 chr1:158549410 OR10X1 -0.36 -7.29 -0.41 3.49e-12 Pneumococcal bacteremia; CESC cis rs3862260 0.509 rs10923879 chr1:120163831 A/G cg11530693 chr1:120165357 ZNF697 0.69 10.58 0.55 4.58e-22 Systemic lupus erythematosus; CESC cis rs9911578 1.000 rs304270 chr17:56802141 A/G cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.43e-11 Intelligence (multi-trait analysis); CESC cis rs3008870 0.920 rs12132532 chr1:67457015 G/T cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -14.14 -0.66 3.43e-34 Lymphocyte percentage of white cells; CESC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg19774624 chr17:42201019 HDAC5 0.74 11.07 0.56 1.14e-23 Total body bone mineral density; CESC cis rs3008870 1.000 rs4655663 chr1:67430103 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.06 0.68 1.87e-37 Lymphocyte percentage of white cells; CESC cis rs2816062 0.775 rs2816048 chr1:18893763 T/C cg18795169 chr1:18902165 NA -0.94 -19.08 -0.76 1.16e-51 Urate levels in lean individuals; CESC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg03647317 chr4:187891568 NA -0.36 -5.07 -0.3 7.33e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs60154123 0.772 rs701942 chr1:210429392 C/G cg23283495 chr1:209979779 IRF6 0.41 5.1 0.3 6.52e-7 Coronary artery disease; CESC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.61 -8.52 -0.46 1.21e-15 Platelet count; CESC cis rs763014 0.898 rs916416 chr16:632198 T/A cg00908189 chr16:619842 PIGQ 0.67 9.34 0.5 4.24e-18 Height; CESC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg09658497 chr7:2847517 GNA12 -0.41 -5.8 -0.34 1.85e-8 Height; CESC cis rs3087591 0.960 rs2905794 chr17:29470002 G/A cg24425628 chr17:29625626 OMG;NF1 0.41 5.13 0.3 5.71e-7 Hip circumference; CESC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC cis rs9811920 0.809 rs1384062 chr3:99597928 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 7.72 0.43 2.44e-13 Axial length; CESC cis rs4566357 0.576 rs3769644 chr2:227917240 C/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.15 -0.4 8.33e-12 Coronary artery disease; CESC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg10578991 chr7:12443926 VWDE -0.4 -5.4 -0.32 1.45e-7 Coronary artery disease; CESC cis rs7923609 1.000 rs10822161 chr10:65118203 G/A cg01631684 chr10:65280961 REEP3 -0.42 -5.17 -0.3 4.72e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs741677 1.000 rs741677 chr17:463843 C/T cg06217071 chr17:408420 NA -0.31 -5.39 -0.31 1.57e-7 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); CESC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg02375832 chr11:62437615 C11orf48 -0.38 -5.48 -0.32 9.81e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs7246657 0.943 rs7257672 chr19:37823859 G/C cg24637308 chr11:6592297 DNHD1 0.53 6.24 0.36 1.74e-9 Coronary artery calcification; CESC cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg10523679 chr1:76189770 ACADM 0.72 8.45 0.46 2.02e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1215050 0.791 rs165242 chr4:98686482 A/C cg05340658 chr4:99064831 C4orf37 -0.47 -5.91 -0.34 1.07e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg04518342 chr5:131593106 PDLIM4 -0.36 -5.05 -0.3 8.21e-7 Breast cancer; CESC cis rs10979 0.651 rs9321921 chr6:143895053 C/T cg25407410 chr6:143891975 LOC285740 -0.53 -7.38 -0.41 1.99e-12 Hypospadias; CESC cis rs7786808 0.615 rs4909212 chr7:158197037 G/T cg01191920 chr7:158217561 PTPRN2 -0.33 -5.47 -0.32 1.04e-7 Obesity-related traits; CESC cis rs17209837 1.000 rs2302385 chr7:87091826 T/C cg00919237 chr7:87102261 ABCB4 -0.53 -6.03 -0.35 5.36e-9 Gallbladder cancer; CESC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.43 5.49 0.32 9.18e-8 Lymphocyte counts; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08151828 chr19:11093828 SMARCA4 -0.43 -6.14 -0.35 2.96e-9 Systemic lupus erythematosus; CESC cis rs4704187 0.687 rs2216638 chr5:74512987 A/G cg03227963 chr5:74354835 NA 0.28 5.04 0.3 8.66e-7 Response to amphetamines; CESC cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg03213289 chr20:61660250 NA 0.39 6.14 0.35 2.96e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs35995292 0.534 rs2392604 chr7:38918012 C/T cg19327137 chr7:38886074 VPS41 0.66 11.04 0.56 1.47e-23 Subjective well-being (multi-trait analysis); CESC cis rs6570726 0.905 rs421032 chr6:145827771 A/G cg23711669 chr6:146136114 FBXO30 0.78 11.62 0.58 1.64e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg26855724 chr1:75198818 TYW3;CRYZ -0.51 -6.56 -0.37 2.83e-10 Resistin levels; CESC trans rs1814175 0.791 rs10769593 chr11:49616217 T/C cg03929089 chr4:120376271 NA -0.88 -14.07 -0.65 5.83e-34 Height; CESC trans rs637571 0.522 rs3016868 chr11:65764383 C/T cg17712092 chr4:129076599 LARP1B 0.75 10.57 0.54 5.01e-22 Eosinophil percentage of white cells; CESC cis rs6088580 0.634 rs6059867 chr20:33078103 C/T cg06115741 chr20:33292138 TP53INP2 0.46 5.86 0.34 1.34e-8 Glomerular filtration rate (creatinine); CESC cis rs2066819 1.000 rs2371494 chr12:56728000 G/A cg26316697 chr12:56727976 PAN2 0.71 6.85 0.39 5.09e-11 Psoriasis vulgaris; CESC cis rs3540 0.597 rs4620932 chr15:91036569 G/A cg10434728 chr15:90938212 IQGAP1 0.42 7.46 0.42 1.28e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs2479106 0.926 rs7868740 chr9:126502000 A/G cg16191174 chr9:126692580 DENND1A 0.48 6.57 0.37 2.65e-10 Polycystic ovary syndrome; CESC cis rs295140 0.566 rs295141 chr2:201163556 C/T cg23649088 chr2:200775458 C2orf69 -0.44 -6.05 -0.35 4.83e-9 QT interval; CESC cis rs9039 1.000 rs67302637 chr16:9221100 C/T cg08831531 chr16:9218945 NA -0.53 -7.02 -0.4 1.87e-11 Menopause (age at onset); CESC cis rs11122272 0.701 rs2474628 chr1:231526000 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs4722166 0.630 rs6969258 chr7:22782528 C/T cg05472934 chr7:22766657 IL6 0.87 10.94 0.56 3.06e-23 Lung cancer; CESC cis rs56163509 1 rs56163509 chr16:28864471 A/G cg05966235 chr16:28915196 ATP2A1 0.34 5.03 0.3 9.05e-7 Tonsillectomy;Mean corpuscular volume; CESC cis rs3733585 0.726 rs4306953 chr4:9955776 G/A cg11266682 chr4:10021025 SLC2A9 -0.57 -10.92 -0.56 3.75e-23 Cleft plate (environmental tobacco smoke interaction); CESC trans rs116095464 0.558 rs9687898 chr5:253952 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.35e-11 Breast cancer; CESC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg08888203 chr3:10149979 C3orf24 0.44 5.71 0.33 3.09e-8 Alzheimer's disease; CESC cis rs1395 0.778 rs6749393 chr2:27451000 C/T cg22903471 chr2:27725779 GCKR -0.42 -5.12 -0.3 5.99e-7 Blood metabolite levels; CESC cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.85 13.7 0.64 1.16e-32 Hip circumference adjusted for BMI; CESC cis rs1538970 0.962 rs9429077 chr1:45820667 C/A cg03146154 chr1:46216737 IPP 0.45 5.39 0.31 1.54e-7 Platelet count; CESC cis rs9487051 0.676 rs7753705 chr6:109593302 A/C cg21918786 chr6:109611834 NA -0.37 -5.41 -0.32 1.39e-7 Reticulocyte fraction of red cells; CESC cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg05340658 chr4:99064831 C4orf37 0.8 12.48 0.61 2e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9549367 0.789 rs9549365 chr13:113907391 C/T cg18105134 chr13:113819100 PROZ 0.69 8.8 0.48 1.78e-16 Platelet distribution width; CESC cis rs11048434 0.673 rs2159961 chr12:9061456 G/T cg23795048 chr12:9217529 LOC144571 0.33 5.23 0.31 3.49e-7 Sjögren's syndrome; CESC cis rs35110281 0.574 rs1836856 chr21:44964638 A/T cg01579765 chr21:45077557 HSF2BP -0.52 -8.68 -0.47 4.24e-16 Mean corpuscular volume; CESC cis rs4472734 1.000 rs10494977 chr1:214622253 C/T cg00063699 chr1:214624242 PTPN14 -0.33 -5.23 -0.31 3.45e-7 Height; CESC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.42 5.61 0.33 5.1e-8 Lymphocyte counts; CESC cis rs9811920 0.541 rs1016914 chr3:99640121 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg24110177 chr3:50126178 RBM5 -0.55 -7.48 -0.42 1.09e-12 Body mass index; CESC cis rs6942756 1.000 rs67820265 chr7:128887925 A/G cg02491457 chr7:128862824 NA -0.71 -10.31 -0.54 3.49e-21 White matter hyperintensity burden; CESC cis rs2281845 0.929 rs6704363 chr1:201096383 A/G cg17810781 chr1:201082982 CACNA1S 0.4 5.56 0.32 6.72e-8 Permanent tooth development; CESC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg27170947 chr2:26402098 FAM59B 0.87 9.85 0.52 1.01e-19 Gut microbiome composition (summer); CESC cis rs7809950 0.817 rs2807 chr7:107260778 G/A cg23024343 chr7:107201750 COG5 0.58 7.55 0.42 6.9e-13 Coronary artery disease; CESC cis rs3784262 1.000 rs12903474 chr15:58276747 A/C cg12031962 chr15:58353849 ALDH1A2 0.34 5.39 0.31 1.58e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs4654899 0.897 rs59537090 chr1:21498737 C/T cg05370193 chr1:21551575 ECE1 0.41 6.22 0.36 1.96e-9 Superior frontal gyrus grey matter volume; CESC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg20607287 chr7:12443886 VWDE -0.71 -8.7 -0.47 3.54e-16 Coronary artery disease; CESC cis rs4253772 0.637 rs8139035 chr22:46651367 A/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.48 5.11 0.3 6.16e-7 LDL cholesterol;Cholesterol, total; CESC cis rs12220238 1.000 rs10824125 chr10:75997498 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.22 0.36 1.89e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg11766577 chr21:47581405 C21orf56 -0.47 -6.32 -0.36 1.12e-9 Testicular germ cell tumor; CESC trans rs9388451 0.513 rs1268069 chr6:126039994 A/C cg05039488 chr6:79577232 IRAK1BP1 -0.49 -6.54 -0.37 3.19e-10 Brugada syndrome; CESC cis rs6800768 0.633 rs6769284 chr3:24148448 T/G cg10674438 chr3:24145617 LOC152024 -0.47 -6.46 -0.37 5.08e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg04944784 chr2:26401820 FAM59B 0.75 8.12 0.45 1.72e-14 Gut microbiome composition (summer); CESC cis rs2658782 1.000 rs2019814 chr11:93168885 A/G cg15737290 chr11:93063684 CCDC67 0.52 6.47 0.37 4.7e-10 Pulmonary function decline; CESC cis rs2425143 0.818 rs73902932 chr20:34489009 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -7.0 -0.39 2.11e-11 Blood protein levels; CESC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg24250549 chr1:154909240 PMVK 0.71 10.52 0.54 7.24e-22 Prostate cancer; CESC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg24739457 chr1:205821442 NA 0.46 6.03 0.35 5.48e-9 Menarche (age at onset); CESC cis rs12479064 0.724 rs2305352 chr2:100015124 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.7 -0.43 2.79e-13 Chronic sinus infection; CESC cis rs10504073 0.647 rs4873096 chr8:49995201 A/G cg00325661 chr8:49890786 NA 0.55 8.17 0.45 1.29e-14 Blood metabolite ratios; CESC cis rs3857067 0.806 rs9307137 chr4:95135712 T/C cg11021082 chr4:95130006 SMARCAD1 -0.57 -8.39 -0.46 2.9e-15 QT interval; CESC cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg26597838 chr10:835615 NA 1.17 11.32 0.57 1.77e-24 Eosinophil percentage of granulocytes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00271154 chr2:113033418 ZC3H6 0.44 6.25 0.36 1.61e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg25405998 chr7:65216604 CCT6P1 0.46 5.21 0.3 3.87e-7 Aortic root size; CESC cis rs929596 0.556 rs10168416 chr2:234597087 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -6.01 -0.35 6.26e-9 Total bilirubin levels in HIV-1 infection; CESC cis rs6089584 0.546 rs6061978 chr20:60615604 C/T cg06108461 chr20:60628389 TAF4 -0.59 -8.01 -0.44 3.65e-14 Body mass index; CESC cis rs2243480 1.000 rs316321 chr7:65611613 G/A cg18252515 chr7:66147081 NA -1.41 -14.48 -0.66 2.11e-35 Diabetic kidney disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05848389 chr14:102508999 DYNC1H1 0.43 6.01 0.35 6.05e-9 Fibrinogen levels; CESC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg07234876 chr8:600039 NA 0.82 6.7 0.38 1.24e-10 IgG glycosylation; CESC cis rs28437878 1 rs28437878 chr15:78807872 C/T cg24631222 chr15:78858424 CHRNA5 0.78 9.5 0.5 1.31e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs951366 0.576 rs1832775 chr1:205734032 C/T cg14893161 chr1:205819251 PM20D1 -0.4 -5.07 -0.3 7.35e-7 Menarche (age at onset); CESC cis rs10751667 0.666 rs6597967 chr11:950583 G/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.35 -0.31 1.86e-7 Alzheimer's disease (late onset); CESC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg09509183 chr1:209979624 IRF6 0.56 5.86 0.34 1.4e-8 Cleft lip with or without cleft palate; CESC cis rs7772486 0.875 rs10457796 chr6:146416087 T/G cg23711669 chr6:146136114 FBXO30 0.81 12.17 0.6 2.27e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs9948 0.708 rs116121826 chr2:97441914 A/G cg01990225 chr2:97406019 LMAN2L -0.92 -7.51 -0.42 9.04e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.35 -5.64 -0.33 4.37e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg07930192 chr7:1003750 NA -0.43 -5.89 -0.34 1.17e-8 Longevity;Endometriosis; CESC cis rs11583043 1.000 rs12750667 chr1:101498682 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.52 5.57 0.32 6.2e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs12220238 0.841 rs10824212 chr10:76371068 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.04 0.3 8.72e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs11098499 0.866 rs10518329 chr4:120401835 A/G cg09307838 chr4:120376055 NA 0.76 10.53 0.54 7.06e-22 Corneal astigmatism; CESC cis rs708547 0.836 rs1315005 chr4:57858237 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.57 -6.62 -0.38 2.03e-10 Response to bleomycin (chromatid breaks); CESC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg07701084 chr6:150067640 NUP43 0.44 5.95 0.34 8.59e-9 Lung cancer; CESC cis rs6964587 0.967 rs28615927 chr7:91600648 C/A cg17063962 chr7:91808500 NA 0.57 7.74 0.43 2.11e-13 Breast cancer; CESC cis rs12497850 0.931 rs7431710 chr3:48935583 G/A cg07636037 chr3:49044803 WDR6 0.98 18.37 0.75 3.7e-49 Parkinson's disease; CESC cis rs28374715 0.532 rs11070328 chr15:41651569 T/C cg02330683 chr15:41787940 ITPKA 0.42 5.05 0.3 8.08e-7 Ulcerative colitis; CESC cis rs67311347 1.000 rs73076046 chr3:40447724 C/T cg24209194 chr3:40518798 ZNF619 0.51 6.27 0.36 1.46e-9 Renal cell carcinoma; CESC cis rs10883723 0.810 rs11191304 chr10:104255284 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs11098499 0.866 rs7677068 chr4:120291704 C/T cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg14416269 chr4:6271139 WFS1 0.46 7.73 0.43 2.23e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs11098499 0.863 rs6534139 chr4:120449456 A/G cg24375607 chr4:120327624 NA -0.43 -5.12 -0.3 5.91e-7 Corneal astigmatism; CESC cis rs7818688 0.653 rs4075834 chr8:95833747 C/T cg16049864 chr8:95962084 TP53INP1 0.55 5.62 0.33 4.81e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs73206853 0.764 rs7960988 chr12:110749918 G/A cg12870014 chr12:110450643 ANKRD13A 0.65 5.48 0.32 9.9e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg16545954 chr1:2118288 C1orf86 0.36 7.05 0.4 1.58e-11 Height; CESC trans rs1814175 0.935 rs6485999 chr11:49658986 G/C cg03929089 chr4:120376271 NA -0.88 -13.45 -0.64 8.7e-32 Height; CESC cis rs992157 0.560 rs1514132 chr2:219084082 C/T cg00012203 chr2:219082015 ARPC2 -0.74 -9.79 -0.52 1.66e-19 Colorectal cancer; CESC cis rs9788682 0.706 rs2656055 chr15:78720194 C/A cg24631222 chr15:78858424 CHRNA5 -0.58 -6.44 -0.37 5.54e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg19622623 chr12:86230825 RASSF9 -0.5 -6.28 -0.36 1.39e-9 Major depressive disorder; CESC cis rs7546094 1.000 rs11102497 chr1:113109274 T/C cg22162597 chr1:113214053 CAPZA1 0.37 5.67 0.33 3.69e-8 Platelet distribution width; CESC cis rs7147624 1.000 rs2898816 chr14:66008160 T/C cg03016385 chr14:66212404 NA -0.49 -5.09 -0.3 6.95e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2439831 0.702 rs16977724 chr15:44151299 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.36 0.41 2.32e-12 Lung cancer in ever smokers; CESC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg18765753 chr7:1198926 ZFAND2A 0.37 5.45 0.32 1.17e-7 Longevity;Endometriosis; CESC cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 5.59 0.32 5.61e-8 Osteoporosis; CESC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg00129232 chr17:37814104 STARD3 -0.56 -7.34 -0.41 2.64e-12 Glomerular filtration rate (creatinine); CESC cis rs2832191 0.967 rs2898160 chr21:30487496 A/G cg08807101 chr21:30365312 RNF160 -0.66 -9.01 -0.48 4.11e-17 Dental caries; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07007080 chr20:44718510 NCOA5 0.55 6.19 0.36 2.3e-9 Gut microbiome composition (summer); CESC cis rs2404602 0.692 rs72738889 chr15:76992063 G/A cg22467129 chr15:76604101 ETFA -0.34 -5.11 -0.3 6.27e-7 Blood metabolite levels; CESC cis rs2795502 1.000 rs2795503 chr10:43347224 T/A cg27426351 chr10:43362370 NA -0.48 -6.05 -0.35 4.79e-9 Blood protein levels; CESC cis rs17780086 0.527 rs72827711 chr17:30537920 T/A cg00745463 chr17:30367425 LRRC37B -0.74 -5.61 -0.33 5.04e-8 Height; CESC cis rs62408225 1.000 rs72925996 chr6:90930513 T/C cg06866423 chr6:90926672 BACH2 0.45 5.35 0.31 1.88e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg06636001 chr8:8085503 FLJ10661 -0.42 -5.25 -0.31 3.16e-7 Mood instability; CESC cis rs754466 0.580 rs17516020 chr10:79538734 C/T cg17075019 chr10:79541650 NA -0.8 -9.91 -0.52 6.87e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10463316 0.894 rs869196 chr5:150746287 G/T cg03212797 chr5:150827313 SLC36A1 -0.47 -6.17 -0.35 2.6e-9 Metabolite levels (Pyroglutamine); CESC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg06456125 chr7:65229604 NA -0.41 -5.41 -0.32 1.4e-7 Aortic root size; CESC cis rs5753618 0.561 rs715510 chr22:31690528 T/A cg13145458 chr22:31556086 RNF185 0.49 5.47 0.32 1.03e-7 Colorectal cancer; CESC cis rs6088580 0.634 rs2225837 chr20:33005634 C/T cg06115741 chr20:33292138 TP53INP2 -0.46 -5.98 -0.34 7.28e-9 Glomerular filtration rate (creatinine); CESC cis rs611744 0.647 rs2594357 chr8:109255989 A/G cg21045802 chr8:109455806 TTC35 0.47 5.75 0.33 2.4e-8 Dupuytren's disease; CESC cis rs12956009 0.583 rs919979 chr18:44902739 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.56 0.37 2.82e-10 Educational attainment (years of education); CESC cis rs798554 1.000 rs798560 chr7:2758309 A/G cg09658497 chr7:2847517 GNA12 -0.36 -5.13 -0.3 5.66e-7 Height; CESC cis rs12893668 0.638 rs11851616 chr14:104065600 G/A cg24130564 chr14:104152367 KLC1 -0.51 -6.46 -0.37 5.02e-10 Reticulocyte count; CESC cis rs7818345 0.845 rs17407039 chr8:19268056 G/A cg11303988 chr8:19266685 CSGALNACT1 0.38 6.6 0.38 2.2e-10 Language performance in older adults (adjusted for episodic memory); CESC cis rs1401999 1.000 rs6767013 chr3:183680102 G/A cg01324343 chr3:183735012 ABCC5 0.63 13.54 0.64 4.16e-32 Anterior chamber depth; CESC cis rs2066819 1.000 rs2629447 chr12:56700809 G/A cg26316697 chr12:56727976 PAN2 -0.69 -6.58 -0.37 2.52e-10 Psoriasis vulgaris; CESC cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.36 5.17 0.3 4.59e-7 Schizophrenia; CESC cis rs72901758 0.768 rs56046325 chr17:76251998 G/T cg26068271 chr17:76253126 NA 0.46 6.54 0.37 3.17e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs4588572 0.643 rs3885254 chr5:77686468 G/A cg11547950 chr5:77652471 NA 0.42 5.21 0.3 3.89e-7 Triglycerides; CESC cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 3.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg22143856 chr6:28129313 ZNF389 0.46 5.84 0.34 1.56e-8 Depression; CESC cis rs17376456 0.877 rs10063045 chr5:93457584 A/T cg25358565 chr5:93447407 FAM172A 1.22 10.94 0.56 3.21e-23 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20365403 chr8:123793477 ZHX2 -0.59 -7.11 -0.4 1.1e-11 Gut microbiome composition (summer); CESC cis rs3126085 0.877 rs1969019 chr1:152211502 A/C cg03465714 chr1:152285911 FLG -0.43 -5.17 -0.3 4.53e-7 Atopic dermatitis; CESC cis rs4629710 0.592 rs67399092 chr6:131582936 G/A cg12606694 chr6:131520996 AKAP7 0.49 5.9 0.34 1.09e-8 Multiple myeloma (IgH translocation); CESC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg10691866 chr7:65817282 TPST1 -0.33 -5.61 -0.33 5.2100000000000003e-08 Aortic root size; CESC cis rs11638352 1.000 rs890465 chr15:44356463 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.5 5.58 0.32 6.01e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs5769765 0.740 rs2103932 chr22:50272515 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.44 5.16 0.3 4.76e-7 Schizophrenia; CESC cis rs123509 0.687 rs73077214 chr3:42838020 G/A cg12982090 chr3:42733453 KBTBD5 -0.66 -7.52 -0.42 8.26e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9863 0.828 rs4765541 chr12:124465995 T/C cg00084347 chr12:124393913 DNAH10 0.27 5.21 0.3 3.88e-7 White blood cell count; CESC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg21285383 chr16:89894308 SPIRE2 -0.31 -5.51 -0.32 8.63e-8 Vitiligo; CESC cis rs854765 0.583 rs9912895 chr17:17826020 C/T cg04398451 chr17:18023971 MYO15A 0.67 9.64 0.51 4.71e-19 Total body bone mineral density; CESC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg22903657 chr4:1355424 KIAA1530 -0.37 -5.08 -0.3 7.13e-7 Obesity-related traits; CESC cis rs3733585 0.781 rs6449183 chr4:9970691 C/A cg00071950 chr4:10020882 SLC2A9 -0.77 -13.79 -0.65 5.54e-33 Cleft plate (environmental tobacco smoke interaction); CESC cis rs3820068 0.705 rs4646072 chr1:15827711 G/A cg17385448 chr1:15911702 AGMAT 0.4 6.14 0.35 3.04e-9 Systolic blood pressure; CESC cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg07636037 chr3:49044803 WDR6 0.61 7.16 0.4 8.07e-12 Menarche (age at onset); CESC cis rs12325245 0.536 rs12709002 chr16:58614337 A/C cg05725404 chr16:58534157 NDRG4 -0.61 -5.24 -0.31 3.35e-7 Schizophrenia; CESC cis rs11239930 0.538 rs4950359 chr1:146558743 C/A cg16700924 chr1:146552102 NA -0.38 -5.04 -0.3 8.56e-7 AIDS progression; CESC trans rs1814175 0.645 rs11040699 chr11:50023798 C/G cg03929089 chr4:120376271 NA -0.91 -14.8 -0.67 1.58e-36 Height; CESC cis rs6430585 0.528 rs79826902 chr2:136670419 G/A cg07169764 chr2:136633963 MCM6 1.23 16.56 0.71 8.67e-43 Corneal structure; CESC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg03709012 chr19:19516395 GATAD2A 0.95 13.98 0.65 1.22e-33 Tonsillectomy; CESC cis rs9325144 0.555 rs1973292 chr12:38679626 T/C cg26384229 chr12:38710491 ALG10B 0.58 8.32 0.45 4.83e-15 Morning vs. evening chronotype; CESC cis rs9815354 1.000 rs7632387 chr3:41853161 C/T cg03022575 chr3:42003672 ULK4 0.54 5.78 0.33 2.06e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg18758796 chr5:131593413 PDLIM4 -0.44 -6.13 -0.35 3.16e-9 Acylcarnitine levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01945625 chr16:1437845 NA 0.43 6.2 0.36 2.1e-9 Fibrinogen levels; CESC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.7 0.38 1.25e-10 Prudent dietary pattern; CESC cis rs3916 0.688 rs9204 chr12:121177778 A/G cg21892295 chr12:121157589 UNC119B -0.34 -5.13 -0.3 5.71e-7 Urinary metabolites (H-NMR features); CESC cis rs11191205 0.774 rs11191203 chr10:103824920 C/T cg15320455 chr10:103880129 LDB1 0.76 6.58 0.37 2.44e-10 Intelligence (multi-trait analysis); CESC cis rs11098499 0.954 rs10031665 chr4:120422852 T/C cg24375607 chr4:120327624 NA 0.46 5.66 0.33 3.87e-8 Corneal astigmatism; CESC cis rs2228479 0.571 rs62052183 chr16:89966921 C/A cg04013166 chr16:89971882 TCF25 0.76 6.94 0.39 3.06e-11 Skin colour saturation; CESC cis rs854765 0.583 rs12452254 chr17:17829434 G/A cg04398451 chr17:18023971 MYO15A -0.65 -9.23 -0.49 9.1e-18 Total body bone mineral density; CESC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg02569458 chr12:86230093 RASSF9 0.49 7.27 0.41 4.07e-12 Major depressive disorder; CESC cis rs8044868 0.586 rs8182213 chr16:72080005 C/T cg01557791 chr16:72042693 DHODH -0.43 -5.89 -0.34 1.17e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs6582630 0.519 rs11495373 chr12:38275470 T/C cg13010199 chr12:38710504 ALG10B 0.48 6.04 0.35 5.23e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7249142 0.549 rs62135499 chr19:19294237 T/C cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.31 5.74 0.33 2.58e-8 IgG glycosylation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01213128 chr5:138629571 MATR3 -0.46 -6.54 -0.37 3.14e-10 Fibrinogen levels; CESC cis rs910316 0.737 rs175045 chr14:75475275 A/C cg11812906 chr14:75593930 NEK9 -0.77 -11.23 -0.57 3.41e-24 Height; CESC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg08859206 chr1:53392774 SCP2 -0.65 -8.86 -0.48 1.22e-16 Monocyte count; CESC cis rs3026101 0.671 rs2107151 chr17:5297338 G/T cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs9916302 0.707 rs11078903 chr17:37631924 G/A cg00129232 chr17:37814104 STARD3 -0.53 -6.91 -0.39 3.67e-11 Glomerular filtration rate (creatinine); CESC cis rs4237845 0.537 rs1599931 chr12:58258850 A/G cg02175503 chr12:58329896 NA 0.49 5.82 0.34 1.69e-8 Intelligence (multi-trait analysis); CESC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 6.88 0.39 4.32e-11 Melanoma; CESC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs9911578 1.000 rs12947785 chr17:57045160 A/C cg12560992 chr17:57184187 TRIM37 0.92 15.24 0.68 4.34e-38 Intelligence (multi-trait analysis); CESC cis rs17376456 1.000 rs13154249 chr5:93550508 C/T cg25358565 chr5:93447407 FAM172A 1.15 11.09 0.56 1.02e-23 Diabetic retinopathy; CESC cis rs933688 1.000 rs889213 chr5:90682151 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.18 14.27 0.66 1.16e-34 Smoking behavior; CESC cis rs2066819 1.000 rs76430365 chr12:56699993 A/C cg26804944 chr12:56660921 COQ10A -0.85 -5.14 -0.3 5.39e-7 Psoriasis vulgaris; CESC cis rs7833986 0.501 rs2953922 chr8:56977485 G/A cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.16 0.3 4.9e-7 Height; CESC cis rs2276314 1.000 rs8086395 chr18:33564592 C/G cg19628046 chr18:33552617 C18orf21 0.55 6.03 0.35 5.49e-9 Endometriosis;Drug-induced torsades de pointes; CESC trans rs931812 0.825 rs6993937 chr8:101898707 A/G cg20993868 chr7:22813445 NA 0.54 7.69 0.43 2.84e-13 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs3820068 0.603 rs1980607 chr1:15975237 A/G cg17385448 chr1:15911702 AGMAT 0.41 6.93 0.39 3.24e-11 Systolic blood pressure; CESC trans rs561341 1.000 rs7214017 chr17:30332220 T/C cg27661571 chr11:113659931 NA -0.7 -7.23 -0.41 5.2e-12 Hip circumference adjusted for BMI; CESC cis rs11792861 0.591 rs7027874 chr9:111717112 A/G cg13535736 chr9:111863775 C9orf5 -0.39 -5.72 -0.33 2.92e-8 Menarche (age at onset); CESC cis rs77741769 0.571 rs11065284 chr12:121266621 G/A cg02419362 chr12:121203948 SPPL3 0.33 5.43 0.32 1.31e-7 Mean corpuscular volume; CESC cis rs2070488 0.662 rs6599203 chr3:38487802 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.69 8.95 0.48 6.3e-17 Electrocardiographic conduction measures; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17157516 chr1:35332203 DLGAP3 0.45 6.07 0.35 4.37e-9 Gut microbiota (bacterial taxa); CESC cis rs4889855 0.545 rs61171555 chr17:78465975 T/G cg16591659 chr17:78472290 NA -0.52 -7.67 -0.43 3.36e-13 Fractional excretion of uric acid; CESC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.92 13.64 0.64 1.92e-32 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27426082 chr6:122720652 HSF2 0.59 6.22 0.36 1.9e-9 Gut microbiome composition (summer); CESC cis rs4523957 0.614 rs7217108 chr17:2059408 G/C cg16513277 chr17:2031491 SMG6 -0.69 -9.59 -0.51 6.97e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9858542 0.537 rs9873994 chr3:49359943 T/C cg00383909 chr3:49044727 WDR6 0.56 5.07 0.3 7.53e-7 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.87e-17 Tonsillectomy; CESC cis rs11676348 0.811 rs4674255 chr2:218987325 C/T cg00012203 chr2:219082015 ARPC2 -0.57 -7.46 -0.42 1.27e-12 Ulcerative colitis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08265551 chr1:151032119 CDC42SE1;MLLT11 -0.47 -6.23 -0.36 1.83e-9 Ulcerative colitis; CESC cis rs7605827 0.930 rs4668449 chr2:15530141 T/C cg19274914 chr2:15703543 NA 0.36 6.43 0.37 6.02e-10 Educational attainment (years of education); CESC cis rs6987853 0.933 rs2974355 chr8:42414117 C/T cg09913449 chr8:42400586 C8orf40 0.4 6.35 0.36 9.55e-10 Mean corpuscular hemoglobin concentration; CESC cis rs765787 0.530 rs28756676 chr15:45540360 G/A cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg19346786 chr7:2764209 NA -0.52 -7.44 -0.42 1.44e-12 Height; CESC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs950776 0.518 rs2292117 chr15:78834689 C/T cg24631222 chr15:78858424 CHRNA5 -0.4 -5.15 -0.3 5.02e-7 Sudden cardiac arrest; CESC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg00129232 chr17:37814104 STARD3 0.59 7.82 0.43 1.22e-13 Glomerular filtration rate (creatinine); CESC cis rs2635047 0.638 rs9956809 chr18:44655843 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 5.51 0.32 8.4e-8 Educational attainment; CESC cis rs9640161 0.789 rs1464752 chr7:150021284 C/T cg13722127 chr7:150037890 RARRES2 0.34 5.11 0.3 6.29e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs262150 1.000 rs262154 chr7:158773936 G/A cg09640425 chr7:158790006 NA -0.37 -5.65 -0.33 4.21e-8 Facial morphology (factor 20); CESC cis rs12995491 0.933 rs34029976 chr2:88537797 T/C cg14558114 chr2:88469736 THNSL2 -0.49 -7.13 -0.4 9.46e-12 Response to metformin (IC50); CESC cis rs3540 0.574 rs8035980 chr15:90974390 C/G cg22089800 chr15:90895588 ZNF774 0.62 8.56 0.47 9.01e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs11098499 0.909 rs73842633 chr4:120375464 G/A cg25214090 chr10:38739885 LOC399744 0.71 9.48 0.5 1.51e-18 Corneal astigmatism; CESC cis rs933688 1.000 rs332544 chr5:90778848 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.84 10.99 0.56 2.12e-23 Smoking behavior; CESC cis rs7131987 1.000 rs7131987 chr12:29406488 G/T cg09582351 chr12:29534625 ERGIC2 -0.33 -5.42 -0.32 1.34e-7 QT interval; CESC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg11764359 chr7:65958608 NA -0.73 -9.77 -0.51 1.93e-19 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05383670 chr11:64879206 TM7SF2 -0.41 -6.28 -0.36 1.37e-9 Gambling; CESC cis rs5753618 0.539 rs2228619 chr22:31663842 C/G cg13145458 chr22:31556086 RNF185 0.48 5.35 0.31 1.88e-7 Colorectal cancer; CESC cis rs11587400 0.514 rs222499 chr1:115146488 C/A cg12756093 chr1:115239321 AMPD1 -0.41 -5.54 -0.32 7.18e-8 Autism; CESC cis rs8070128 0.534 rs2955350 chr17:17953548 G/A cg04398451 chr17:18023971 MYO15A 0.73 10.55 0.54 5.95e-22 Total body bone mineral density; CESC cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg12193833 chr17:30244370 NA -0.79 -7.22 -0.41 5.57e-12 Hip circumference adjusted for BMI; CESC cis rs977987 0.843 rs17696749 chr16:75403062 C/G cg03315344 chr16:75512273 CHST6 0.4 5.77 0.33 2.26e-8 Dupuytren's disease; CESC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.4 0.57 9.22e-25 Alzheimer's disease; CESC cis rs11098499 0.863 rs10018280 chr4:120478139 T/G cg09307838 chr4:120376055 NA 0.9 12.46 0.61 2.29e-28 Corneal astigmatism; CESC cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg11366901 chr6:160182831 ACAT2 0.76 8.82 0.48 1.57e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg26338869 chr17:61819248 STRADA 0.69 9.08 0.49 2.62e-17 Prudent dietary pattern; CESC cis rs2228479 0.850 rs17233567 chr16:89813821 G/A cg19635926 chr16:89946313 TCF25 0.68 5.17 0.3 4.67e-7 Skin colour saturation; CESC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg22535103 chr8:58192502 C8orf71 -0.93 -10.32 -0.54 3.27e-21 Developmental language disorder (linguistic errors); CESC cis rs35110281 0.748 rs162403 chr21:44963365 C/G cg01579765 chr21:45077557 HSF2BP -0.55 -9.17 -0.49 1.4e-17 Mean corpuscular volume; CESC cis rs7084402 0.967 rs1658480 chr10:60289374 C/G cg07615347 chr10:60278583 BICC1 0.61 9.68 0.51 3.68e-19 Refractive error; CESC cis rs12497850 0.863 rs4858799 chr3:48728204 G/C cg07636037 chr3:49044803 WDR6 0.92 15.42 0.69 1.03e-38 Parkinson's disease; CESC cis rs796364 0.951 rs971232 chr2:200792881 C/T cg23649088 chr2:200775458 C2orf69 0.55 5.24 0.31 3.29e-7 Schizophrenia; CESC cis rs7216064 1.000 rs7216064 chr17:65898809 G/A cg07042672 chr17:66097459 LOC651250 -0.55 -5.96 -0.34 8.12e-9 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs3091242 0.933 rs932372 chr1:25755014 G/A cg02931644 chr1:25747376 RHCE 0.42 7.0 0.4 2.06e-11 Erythrocyte sedimentation rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11312980 chr14:64931897 AKAP5 -0.64 -7.99 -0.44 4.13e-14 Gut microbiome composition (summer); CESC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg24562669 chr7:97807699 LMTK2 0.49 6.98 0.39 2.41e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs909002 0.849 rs10914453 chr1:32075036 A/G cg13919466 chr1:32135498 COL16A1 -0.48 -8.47 -0.46 1.66e-15 Intelligence (multi-trait analysis); CESC cis rs2708240 1.000 rs2538983 chr7:147581837 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.55 -0.32 7.07e-8 QT interval (drug interaction); CESC cis rs2228479 0.717 rs2286392 chr16:89809549 A/G cg27121462 chr16:89883253 FANCA 0.63 5.51 0.32 8.36e-8 Skin colour saturation; CESC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Parkinson's disease; CESC cis rs4728302 0.869 rs2059298 chr7:133603245 C/G cg10665199 chr7:133106180 EXOC4 0.4 5.56 0.32 6.62e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg24308560 chr3:49941425 MST1R -0.63 -9.14 -0.49 1.64e-17 Intelligence (multi-trait analysis); CESC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg26314531 chr2:26401878 FAM59B -0.59 -6.07 -0.35 4.5e-9 Gut microbiome composition (summer); CESC cis rs9467711 0.516 rs1324088 chr6:25841122 C/T cg08501292 chr6:25962987 TRIM38 0.54 5.88 0.34 1.2e-8 Autism spectrum disorder or schizophrenia; CESC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.49 0.32 9.47e-8 Bipolar disorder; CESC cis rs11030122 0.687 rs10835521 chr11:4056004 A/T cg18678763 chr11:4115507 RRM1 -0.44 -6.0 -0.35 6.52e-9 Mean platelet volume;Platelet distribution width; CESC cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg16339924 chr4:17578868 LAP3 0.63 8.03 0.44 3.2e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg00989853 chr1:209979345 IRF6 0.36 6.5 0.37 3.93e-10 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs9287719 0.967 rs12995602 chr2:10753542 C/A cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs9486719 1.000 rs2499804 chr6:96861216 A/G cg18709589 chr6:96969512 KIAA0776 0.49 5.45 0.32 1.15e-7 Migraine;Coronary artery disease; CESC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg24829409 chr8:58192753 C8orf71 -0.61 -7.02 -0.4 1.9e-11 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20650035 chr12:29542837 NA -0.63 -7.73 -0.43 2.29e-13 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11161882 chr1:228594712 TRIM11 -0.51 -6.07 -0.35 4.33e-9 Ulcerative colitis; CESC cis rs3015497 0.616 rs4901044 chr14:51090295 A/G cg09863266 chr14:51125203 SAV1 -0.32 -5.06 -0.3 7.7300000000000005e-07 Mean platelet volume; CESC trans rs561341 1.000 rs4795667 chr17:30244443 T/C cg20587970 chr11:113659929 NA -1.11 -13.67 -0.64 1.52e-32 Hip circumference adjusted for BMI; CESC cis rs7267979 0.903 rs2500423 chr20:25374882 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -15.92 -0.7 1.72e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg00033643 chr7:134001901 SLC35B4 0.4 5.13 0.3 5.53e-7 Mean platelet volume; CESC cis rs2243480 0.901 rs3813708 chr7:65305632 C/A cg25894440 chr7:65020034 NA -0.65 -5.57 -0.32 6.4e-8 Diabetic kidney disease; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg12977448 chr10:14920832 SUV39H2 -0.49 -6.64 -0.38 1.78e-10 Height; CESC trans rs629535 0.862 rs638412 chr8:70047690 C/T cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs9291683 0.588 rs4697705 chr4:10108127 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -8.47 -0.46 1.74e-15 Bone mineral density; CESC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.45e-9 Developmental language disorder (linguistic errors); CESC cis rs9430161 0.579 rs9659356 chr1:11034817 A/G cg02454025 chr1:11042201 C1orf127 0.96 15.62 0.69 1.91e-39 Ewing sarcoma; CESC cis rs56046484 0.956 rs12908535 chr15:85601525 C/G cg08123816 chr15:85640762 PDE8A -0.51 -6.28 -0.36 1.36e-9 Testicular germ cell tumor; CESC cis rs2573652 0.674 rs11630619 chr15:100543367 G/A cg09918751 chr15:100517450 ADAMTS17 -0.3 -5.57 -0.32 6.12e-8 Height; CESC cis rs9905704 0.836 rs12952429 chr17:56843070 C/T cg12560992 chr17:57184187 TRIM37 0.63 7.72 0.43 2.41e-13 Testicular germ cell tumor; CESC cis rs4409675 0.576 rs6662916 chr1:28219873 G/T cg23691781 chr1:28212827 C1orf38 0.3 5.92 0.34 1.02e-8 Corneal astigmatism; CESC cis rs3008870 0.755 rs1570838 chr1:67403315 C/T cg02640540 chr1:67518911 SLC35D1 0.46 5.58 0.32 5.81e-8 Lymphocyte percentage of white cells; CESC cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg25019033 chr10:957182 NA -0.58 -6.18 -0.35 2.45e-9 Eosinophil percentage of granulocytes; CESC cis rs9467773 0.620 rs9467810 chr6:26608261 A/C cg20266910 chr6:26577678 NA 0.35 5.85 0.34 1.44e-8 Intelligence (multi-trait analysis); CESC cis rs2251381 0.750 rs2255055 chr21:30537045 C/T cg08807101 chr21:30365312 RNF160 0.66 8.21 0.45 9.48e-15 Selective IgA deficiency; CESC cis rs10752881 0.935 rs3935221 chr1:182969010 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 13.7 0.64 1.16e-32 Colorectal cancer; CESC cis rs919433 1.000 rs1429414 chr2:198162430 C/T cg03934865 chr2:198174659 NA -0.43 -6.26 -0.36 1.55e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs11690961 0.627 rs11690238 chr2:46371723 C/T cg12428440 chr2:46370979 PRKCE -0.51 -5.46 -0.32 1.1e-7 Pulse pressure; CESC cis rs4253772 0.515 rs9615968 chr22:46772695 A/G cg00784671 chr22:46762841 CELSR1 -0.71 -5.98 -0.34 7.38e-9 LDL cholesterol;Cholesterol, total; CESC cis rs1712517 0.588 rs12220267 chr10:105075712 C/T cg04362960 chr10:104952993 NT5C2 -0.46 -5.49 -0.32 9.22e-8 Migraine; CESC cis rs9354308 0.834 rs12212376 chr6:66598879 T/C cg07460842 chr6:66804631 NA 0.62 7.1 0.4 1.16e-11 Metabolite levels; CESC cis rs6537837 0.793 rs12045311 chr1:110087405 T/C cg05049280 chr1:110155535 GNAT2 0.39 5.56 0.32 6.71e-8 Major depressive disorder; CESC cis rs3736594 0.765 rs12994085 chr2:27952406 C/T cg27432699 chr2:27873401 GPN1 -0.37 -5.14 -0.3 5.32e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs1018836 0.828 rs4735236 chr8:91583909 A/G cg16814680 chr8:91681699 NA -0.67 -9.74 -0.51 2.4e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2777491 1.000 rs316610 chr15:41752852 C/T cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.9 -0.52 7.01e-20 Ulcerative colitis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg25632300 chr5:174905618 SFXN1 0.44 6.08 0.35 4.08e-9 Height; CESC cis rs10911232 0.560 rs10911221 chr1:183046737 G/C ch.1.3577855R chr1:183094577 LAMC1 0.82 12.63 0.61 6.02e-29 Hypertriglyceridemia; CESC cis rs7107174 1.000 rs4945268 chr11:78037936 T/C cg02023728 chr11:77925099 USP35 0.52 6.86 0.39 4.74e-11 Testicular germ cell tumor; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg23260799 chr11:451101 PTDSS2 0.48 6.08 0.35 4.12e-9 Tetralogy of Fallot; CESC cis rs524281 0.731 rs3829937 chr11:65787666 G/A cg14036092 chr11:66035641 RAB1B -0.63 -5.73 -0.33 2.79e-8 Electroencephalogram traits; CESC cis rs3733585 0.699 rs28613263 chr4:9964880 C/T cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6582630 0.593 rs7134006 chr12:38596245 A/C cg26384229 chr12:38710491 ALG10B 0.73 10.91 0.56 4.06e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs16854884 0.537 rs16855026 chr3:143868350 A/C cg06585982 chr3:143692056 C3orf58 0.45 5.76 0.33 2.37e-8 Economic and political preferences (feminism/equality); CESC cis rs765787 0.530 rs11636410 chr15:45535913 A/C cg24006582 chr15:45444508 DUOX1 0.57 6.76 0.38 8.71e-11 Uric acid levels; CESC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg07395648 chr5:131743802 NA -0.44 -5.82 -0.34 1.71e-8 Breast cancer; CESC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg10792982 chr14:105748885 BRF1 0.41 5.26 0.31 2.96e-7 Mean platelet volume;Platelet distribution width; CESC cis rs5753618 0.583 rs9606843 chr22:31853371 A/C cg13145458 chr22:31556086 RNF185 -0.51 -5.97 -0.34 7.59e-9 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08470759 chr2:95825297 ZNF514 0.61 7.04 0.4 1.63e-11 Gut microbiome composition (summer); CESC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.87 8.79 0.47 1.98e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6570726 0.764 rs9403731 chr6:145907937 G/A cg05347473 chr6:146136440 FBXO30 0.55 7.2 0.4 6.24e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.69 9.01 0.48 4.25e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs3096299 0.746 rs9931120 chr16:89501357 A/G cg08392591 chr16:89556376 ANKRD11 0.51 6.6 0.38 2.18e-10 Multiple myeloma (IgH translocation); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg13495167 chr12:114395501 RBM19 0.5 6.35 0.36 9.18e-10 Cleft plate (environmental tobacco smoke interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07881228 chr7:30068068 PLEKHA8 -0.42 -6.05 -0.35 5.05e-9 Fibrinogen levels; CESC cis rs7116495 0.737 rs670802 chr11:71799668 A/C cg26138937 chr11:71823887 C11orf51 -0.84 -6.76 -0.38 8.55e-11 Severe influenza A (H1N1) infection; CESC cis rs3087591 0.960 rs9896041 chr17:29571326 C/G cg24425628 chr17:29625626 OMG;NF1 -0.42 -5.03 -0.3 9.19e-7 Hip circumference; CESC cis rs5769765 0.955 rs9616366 chr22:50301178 C/T cg02269571 chr22:50332266 NA -0.49 -6.5 -0.37 4.02e-10 Schizophrenia; CESC cis rs4555082 1.000 rs7146683 chr14:105759385 A/G cg06808227 chr14:105710500 BRF1 -0.54 -6.74 -0.38 9.61e-11 Mean platelet volume;Platelet distribution width; CESC cis rs10751667 0.643 rs10902237 chr11:944801 C/A cg06064525 chr11:970664 AP2A2 -0.54 -10.94 -0.56 3.16e-23 Alzheimer's disease (late onset); CESC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg07701084 chr6:150067640 NUP43 0.4 5.51 0.32 8.53e-8 Lung cancer; CESC cis rs1949733 0.523 rs16842560 chr4:8544238 G/A cg11789530 chr4:8429930 ACOX3 -0.57 -7.06 -0.4 1.43e-11 Response to antineoplastic agents; CESC cis rs7818345 0.904 rs11780388 chr8:19271554 A/G cg11303988 chr8:19266685 CSGALNACT1 0.32 5.6 0.33 5.44e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs1577917 1.000 rs1999852 chr6:86705738 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.43 -0.37 5.9e-10 Response to antipsychotic treatment; CESC cis rs4568518 0.740 rs10428925 chr7:18009205 T/G cg03009463 chr7:17980271 SNX13 0.46 6.0 0.35 6.45e-9 Measles; CESC cis rs7507204 0.530 rs4807470 chr19:3443470 A/T cg08380311 chr19:3435252 NFIC 0.8 12.3 0.6 8.38e-28 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24688909 chr22:47059079 GRAMD4 -0.66 -7.92 -0.44 6.49e-14 Gut microbiome composition (summer); CESC cis rs9287719 0.967 rs759403 chr2:10729897 C/T cg02196655 chr2:10830764 NOL10 -0.36 -5.57 -0.32 6.1e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09260951 chr22:39096513 JOSD1 0.57 6.57 0.37 2.6e-10 Gut microbiome composition (summer); CESC cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg11161846 chr1:160990452 F11R -0.39 -5.3 -0.31 2.42e-7 Granulocyte percentage of myeloid white cells; CESC cis rs9581857 0.556 rs9579085 chr13:28041039 G/A cg22138327 chr13:27999177 GTF3A 0.65 7.19 0.4 6.76e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs6748734 1.000 rs6751693 chr2:241837332 T/C cg07537917 chr2:241836409 C2orf54 -0.26 -5.45 -0.32 1.17e-7 Urinary metabolites; CESC cis rs10242455 0.702 rs7794068 chr7:99146873 A/T cg25640893 chr7:99214727 ZNF498 0.76 5.92 0.34 9.75e-9 Blood metabolite levels; CESC cis rs2832191 0.716 rs1888439 chr21:30454457 A/G cg24692254 chr21:30365293 RNF160 0.97 16.85 0.72 8.59e-44 Dental caries; CESC cis rs7918232 0.941 rs7096505 chr10:27326999 T/C cg14442939 chr10:27389572 ANKRD26 0.62 5.98 0.34 7.18e-9 Breast cancer; CESC cis rs6598955 0.670 rs7520517 chr1:26556385 A/C cg04990556 chr1:26633338 UBXN11 -0.76 -10.75 -0.55 1.34e-22 Obesity-related traits; CESC cis rs2228479 0.557 rs11648881 chr16:89862434 T/C cg06558623 chr16:89946397 TCF25 1.13 8.85 0.48 1.3e-16 Skin colour saturation; CESC cis rs9987353 0.566 rs34491841 chr8:9065510 C/A cg06636001 chr8:8085503 FLJ10661 -0.6 -7.09 -0.4 1.24e-11 Recombination measurement; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09921884 chr19:1138906 SBNO2 0.45 6.09 0.35 3.92e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9467711 0.659 rs66757203 chr6:26454956 C/T cg14345882 chr6:26364793 BTN3A2 0.64 5.28 0.31 2.67e-7 Autism spectrum disorder or schizophrenia; CESC trans rs757081 0.606 rs679201 chr11:17200891 T/C cg00391031 chr10:72237473 KIAA1274 0.31 6.05 0.35 4.99e-9 Systolic blood pressure; CESC trans rs1814175 0.645 rs11040699 chr11:50023798 C/G cg15704280 chr7:45808275 SEPT13 -1.0 -18.54 -0.75 9.01e-50 Height; CESC cis rs1499972 0.941 rs62263115 chr3:117622116 G/A cg07612923 chr3:117604196 NA 0.88 7.62 0.42 4.47e-13 Schizophrenia; CESC cis rs3741151 0.686 rs7118982 chr11:73110668 T/C cg17517138 chr11:73019481 ARHGEF17 0.72 6.09 0.35 4.05e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg10792982 chr14:105748885 BRF1 0.4 5.38 0.31 1.64e-7 Mean platelet volume;Platelet distribution width; CESC cis rs28489187 0.597 rs1001604 chr1:85879524 C/G cg16011679 chr1:85725395 C1orf52 -0.43 -5.1 -0.3 6.49e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs1941023 0.568 rs1373064 chr11:60168200 C/T cg08716584 chr11:60157161 MS4A7 -0.55 -9.03 -0.48 3.7e-17 Congenital heart disease (maternal effect); CESC cis rs861020 0.606 rs695140 chr1:210005061 G/A cg05527609 chr1:210001259 C1orf107 0.74 9.67 0.51 3.97e-19 Orofacial clefts; CESC cis rs926938 0.527 rs360679 chr1:115494121 G/T cg12756093 chr1:115239321 AMPD1 0.46 6.37 0.36 8.1e-10 Autism; CESC cis rs72634258 0.945 rs7522911 chr1:8097145 C/T cg00042356 chr1:8021962 PARK7 0.8 7.14 0.4 9.2e-12 Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05747105 chr6:53224391 NA 0.63 7.77 0.43 1.73e-13 Gut microbiome composition (summer); CESC cis rs9910055 0.615 rs189049 chr17:42197213 A/C cg13607699 chr17:42295918 UBTF -0.6 -7.85 -0.43 1.06e-13 Total body bone mineral density; CESC cis rs9908102 0.740 rs8079600 chr17:12910706 T/C cg26162695 chr17:12921313 ELAC2 0.52 5.71 0.33 3.04e-8 Schizophrenia; CESC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg15145296 chr3:125709740 NA -0.47 -5.22 -0.31 3.63e-7 Blood pressure (smoking interaction); CESC cis rs2412208 0.585 rs11120824 chr1:7113591 G/A cg20434152 chr1:7120926 CAMTA1 -0.32 -5.14 -0.3 5.27e-7 Survival in sporadic amyotrophic lateral sclerosis; CESC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg09658497 chr7:2847517 GNA12 -0.44 -6.51 -0.37 3.81e-10 Height; CESC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg17971929 chr21:40555470 PSMG1 1.07 16.31 0.71 7.07e-42 Cognitive function; CESC cis rs9303401 0.734 rs8073316 chr17:57211381 A/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.65 -8.25 -0.45 7.64e-15 Cognitive test performance; CESC cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg05234568 chr11:5960015 NA 0.51 5.8 0.34 1.84e-8 DNA methylation (variation); CESC cis rs66530629 0.874 rs1890449 chr1:25075801 G/T cg22509179 chr1:25234806 RUNX3 0.42 5.38 0.31 1.66e-7 Plateletcrit; CESC cis rs2066819 0.901 rs773665 chr12:56717466 C/T cg26316697 chr12:56727976 PAN2 -0.69 -6.58 -0.37 2.52e-10 Psoriasis vulgaris; CESC cis rs965469 0.779 rs6051772 chr20:3328654 C/G cg17110299 chr20:3385021 C20orf194 0.4 5.25 0.31 3.1e-7 IFN-related cytopenia; CESC cis rs4835473 0.800 rs1849117 chr4:144910944 C/T cg25736465 chr4:144833511 NA 0.41 6.3 0.36 1.2e-9 Immature fraction of reticulocytes; CESC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.96 -0.52 4.63e-20 Developmental language disorder (linguistic errors); CESC cis rs2294693 0.947 rs10456496 chr6:40988840 A/G cg14418226 chr6:40996092 UNC5CL -0.43 -5.6 -0.33 5.4e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg02428538 chr16:24856791 SLC5A11 -0.6 -5.88 -0.34 1.26e-8 Intelligence (multi-trait analysis); CESC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg22800045 chr5:56110881 MAP3K1 0.84 10.31 0.53 3.63e-21 Initial pursuit acceleration; CESC cis rs3749237 0.595 rs4855861 chr3:49525962 G/T cg07636037 chr3:49044803 WDR6 0.61 8.81 0.48 1.66e-16 Resting heart rate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00597555 chr15:90177036 KIF7 0.46 6.06 0.35 4.72e-9 Fibrinogen levels; CESC cis rs9393777 0.623 rs34313099 chr6:26489607 C/T cg14345882 chr6:26364793 BTN3A2 0.44 5.39 0.31 1.59e-7 Intelligence (multi-trait analysis); CESC cis rs9796 0.866 rs544744 chr15:41366290 G/C cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.23 -0.36 1.78e-9 Menopause (age at onset); CESC cis rs1801251 1.000 rs7578299 chr2:233573469 G/T cg08000102 chr2:233561755 GIGYF2 0.68 9.27 0.49 6.96e-18 Coronary artery disease; CESC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg18305652 chr10:134549665 INPP5A 0.51 7.53 0.42 8.2e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs3741798 1.000 rs61922026 chr12:12486428 C/G cg08615371 chr12:12503544 MANSC1 0.88 6.45 0.37 5.4e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9303401 0.703 rs9909925 chr17:57210069 C/T cg12560992 chr17:57184187 TRIM37 -0.49 -5.87 -0.34 1.33e-8 Cognitive test performance; CESC cis rs6866344 0.697 rs58549512 chr5:178133204 C/T cg03877680 chr5:178157825 ZNF354A 0.75 8.41 0.46 2.52e-15 Neutrophil percentage of white cells; CESC trans rs1814175 0.935 rs10839317 chr11:49657228 A/C cg03929089 chr4:120376271 NA -0.88 -13.45 -0.64 8.7e-32 Height; CESC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg13607699 chr17:42295918 UBTF 0.63 8.36 0.46 3.49e-15 Total body bone mineral density; CESC cis rs7264396 0.790 rs8125090 chr20:34360015 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.64 7.66 0.43 3.4e-13 Total cholesterol levels; CESC cis rs9929218 0.906 rs9933844 chr16:68747001 G/A cg02972257 chr16:68554789 NA 0.57 6.4 0.37 7.06e-10 Colorectal cancer; CESC cis rs2882667 0.858 rs17207870 chr5:138387737 T/C cg04439458 chr5:138467593 SIL1 -0.39 -6.28 -0.36 1.37e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs17116334 1.000 rs17116334 chr11:113961762 C/T cg12598837 chr11:113845788 HTR3A 0.29 5.76 0.33 2.37e-8 Conduct disorder (maternal expressed emotions interaction); CESC cis rs10089 0.953 rs1012851 chr5:127360241 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 9.53 0.51 1.09e-18 Ileal carcinoids; CESC cis rs9790314 0.586 rs1811483 chr3:161130900 A/G cg03342759 chr3:160939853 NMD3 -0.41 -5.18 -0.3 4.35e-7 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs1869897 chr4:98730997 C/T cg05340658 chr4:99064831 C4orf37 0.74 10.56 0.54 5.51e-22 Colonoscopy-negative controls vs population controls; CESC cis rs4919694 1.000 rs7100592 chr10:104769098 T/G cg04362960 chr10:104952993 NT5C2 0.75 6.44 0.37 5.54e-10 Arsenic metabolism; CESC cis rs11690935 1.000 rs12053003 chr2:172537350 A/C cg13550731 chr2:172543902 DYNC1I2 0.96 14.94 0.68 4.88e-37 Schizophrenia; CESC cis rs637571 0.524 rs674363 chr11:65699134 G/A cg26695010 chr11:65641043 EFEMP2 0.42 5.22 0.31 3.67e-7 Eosinophil percentage of white cells; CESC cis rs8099014 0.861 rs8097365 chr18:56131080 G/A cg19312305 chr18:56117016 MIR122 -0.27 -5.3 -0.31 2.4e-7 Platelet count; CESC cis rs11122272 0.735 rs2491412 chr1:231535880 A/T cg06096015 chr1:231504339 EGLN1 0.39 5.53 0.32 7.83e-8 Hemoglobin concentration; CESC cis rs977987 0.778 rs11149825 chr16:75434878 C/T cg03315344 chr16:75512273 CHST6 0.39 5.61 0.33 5.15e-8 Dupuytren's disease; CESC trans rs55704346 0.566 rs2292410 chr4:25394339 A/G cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.11 19.33 0.76 1.54e-52 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07136949 chr6:7986672 MGC26597 -0.42 -5.99 -0.35 6.65e-9 Gut microbiota (bacterial taxa); CESC cis rs1371867 0.846 rs1788203 chr8:101303721 T/C cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.24e-11 Atrioventricular conduction; CESC cis rs9443189 0.901 rs2038624 chr6:76560707 T/C cg01950844 chr6:76311363 SENP6 -0.59 -6.22 -0.36 1.88e-9 Prostate cancer; CESC cis rs7520050 0.931 rs11211198 chr1:46282673 G/A cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.38e-7 Red blood cell count;Reticulocyte count; CESC cis rs1707322 0.686 rs2230658 chr1:46078854 A/G cg05343316 chr1:45956843 TESK2 -0.53 -6.45 -0.37 5.42e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2228479 0.717 rs12917681 chr16:89810941 C/A cg27121462 chr16:89883253 FANCA 0.64 5.6 0.33 5.41e-8 Skin colour saturation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17810853 chr3:53879737 IL17RB;CHDH -0.46 -6.37 -0.36 8.44e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15825928 chr6:126964945 NA -0.5 -6.26 -0.36 1.56e-9 Gut microbiome composition (summer); CESC cis rs9486719 0.947 rs72932805 chr6:96902933 T/G cg18709589 chr6:96969512 KIAA0776 -0.54 -5.97 -0.34 7.42e-9 Migraine;Coronary artery disease; CESC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg24829409 chr8:58192753 C8orf71 0.59 7.31 0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg15145296 chr3:125709740 NA -0.52 -5.47 -0.32 1.06e-7 Blood pressure (smoking interaction); CESC cis rs3733585 0.673 rs4407505 chr4:9953367 T/G cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7071206 0.853 rs57420220 chr10:79428886 C/T cg00983440 chr10:79422392 NA -0.66 -7.91 -0.44 7.23e-14 Bone mineral density; CESC cis rs3741151 0.881 rs12099129 chr11:73091318 T/G cg17517138 chr11:73019481 ARHGEF17 0.97 6.53 0.37 3.3e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08974500 chr6:170863287 PSMB1;TBP -0.45 -6.85 -0.39 5.11e-11 Gambling; CESC cis rs9625935 0.518 rs9614086 chr22:30259608 A/C cg01021169 chr22:30184971 ASCC2 0.41 6.41 0.37 6.8e-10 Tonsillectomy; CESC cis rs1878931 0.697 rs1044390 chr16:3432594 T/A cg21433313 chr16:3507492 NAT15 -0.37 -5.54 -0.32 7.38e-8 Body mass index (adult); CESC cis rs6674176 0.660 rs2108202 chr1:44395786 A/G cg15962314 chr1:44399869 ARTN -0.28 -5.15 -0.3 5.13e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg12826209 chr6:26865740 GUSBL1 -0.77 -8.79 -0.48 1.92e-16 Intelligence (multi-trait analysis); CESC cis rs9616064 0.531 rs66909472 chr22:47050210 G/A cg05621596 chr22:47072043 GRAMD4 -0.68 -9.8 -0.52 1.45e-19 Urate levels in obese individuals; CESC cis rs778371 0.578 rs2675956 chr2:233753340 G/A cg08000102 chr2:233561755 GIGYF2 -0.77 -12.05 -0.59 5.84e-27 Schizophrenia; CESC cis rs870825 0.698 rs2696046 chr4:185599972 G/A cg04058563 chr4:185651563 MLF1IP -0.51 -5.05 -0.3 8.2e-7 Blood protein levels; CESC cis rs9660992 0.626 rs1172113 chr1:205226288 T/C cg00857998 chr1:205179979 DSTYK 0.5 6.25 0.36 1.62e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs2303759 0.709 rs8102574 chr19:49828897 A/G cg22307029 chr19:49891270 CCDC155 0.54 5.97 0.34 7.51e-9 Multiple sclerosis; CESC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs8067545 0.611 rs2526477 chr17:20131193 A/G cg13482628 chr17:19912719 NA -0.4 -5.32 -0.31 2.23e-7 Schizophrenia; CESC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg25067162 chr17:41277974 BRCA1;NBR2 0.38 5.08 0.3 7.24e-7 Menopause (age at onset); CESC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg03538708 chr1:25844672 NA -0.38 -5.63 -0.33 4.61e-8 Erythrocyte sedimentation rate; CESC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.48 -0.5 1.49e-18 Alzheimer's disease; CESC cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg03467027 chr4:99064603 C4orf37 -0.46 -5.73 -0.33 2.73e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg12262378 chr17:6899522 ALOX12 0.39 6.61 0.38 2.07e-10 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23200970 chr4:111119917 ELOVL6 0.61 6.94 0.39 2.95e-11 Gut microbiome composition (summer); CESC cis rs1707322 0.721 rs10157795 chr1:46228192 G/A cg06784218 chr1:46089804 CCDC17 0.4 7.33 0.41 2.85e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs854765 0.964 rs12943202 chr17:17994332 T/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.46 -5.83 -0.34 1.64e-8 Total body bone mineral density; CESC cis rs213032 1.000 rs213028 chr1:21652177 A/G cg16416158 chr1:21652298 ECE1 -0.32 -5.41 -0.32 1.43e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00423702 chr7:66747538 NA -0.41 -6.01 -0.35 6.08e-9 Gut microbiome composition (summer); CESC cis rs6540556 0.517 rs1474654 chr1:209884387 A/G cg05527609 chr1:210001259 C1orf107 -0.73 -7.15 -0.4 8.66e-12 Red blood cell count; CESC cis rs2576037 0.796 rs2571020 chr18:44584189 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.44 5.61 0.33 4.97e-8 Personality dimensions; CESC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg18016565 chr1:150552671 MCL1 0.33 5.16 0.3 4.96e-7 Tonsillectomy; CESC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg25036284 chr2:26402008 FAM59B 0.81 8.91 0.48 8.33e-17 Gut microbiome composition (summer); CESC cis rs7829975 0.514 rs2976929 chr8:8258712 T/C cg15556689 chr8:8085844 FLJ10661 0.57 7.52 0.42 8.55e-13 Mood instability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00923803 chr7:5862740 ZNF815 0.53 6.81 0.39 6.47e-11 Gut microbiome composition (summer); CESC cis rs11650494 0.908 rs75092916 chr17:47412578 T/C cg08112188 chr17:47440006 ZNF652 1.31 8.52 0.46 1.22e-15 Prostate cancer; CESC cis rs7589342 0.929 rs7562054 chr2:106433513 G/C cg16077055 chr2:106428750 NCK2 0.53 7.56 0.42 6.6e-13 Addiction; CESC cis rs28489187 0.706 rs66811655 chr1:85831544 T/G cg16011679 chr1:85725395 C1orf52 0.57 6.38 0.36 7.83e-10 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs11088226 0.581 rs2833856 chr21:33877691 A/G cg09050820 chr6:167586206 TCP10L2 -0.47 -6.03 -0.35 5.53e-9 Gastritis; CESC cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg08847533 chr14:75593920 NEK9 -0.93 -15.99 -0.7 9.36e-41 Height; CESC cis rs11098499 0.863 rs7695620 chr4:120452776 G/A cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.24e-28 Corneal astigmatism; CESC trans rs2727020 0.521 rs4980445 chr11:49570183 C/T cg03929089 chr4:120376271 NA -0.73 -8.38 -0.46 3.16e-15 Coronary artery disease; CESC cis rs13385 0.769 rs17118759 chr5:139617407 A/G cg26211634 chr5:139558579 C5orf32 0.48 5.27 0.31 2.79e-7 Atrial fibrillation; CESC cis rs11696501 0.688 rs6065861 chr20:44311056 A/G cg11783356 chr20:44313418 WFDC10B -0.31 -5.07 -0.3 7.57e-7 Brain structure; CESC cis rs782590 0.556 rs782579 chr2:55917604 A/G cg18811423 chr2:55921094 PNPT1 0.74 11.56 0.58 2.72e-25 Metabolic syndrome; CESC cis rs1670533 1.000 rs688785 chr4:1082707 G/C cg27284194 chr4:1044797 NA 0.48 6.07 0.35 4.52e-9 Recombination rate (females); CESC cis rs6964587 1.000 rs6465343 chr7:91618208 T/C cg17063962 chr7:91808500 NA 0.56 7.66 0.43 3.61e-13 Breast cancer; CESC cis rs7828089 0.582 rs13282084 chr8:22266280 T/C cg23129673 chr8:22266227 SLC39A14 0.37 5.47 0.32 1.03e-7 Verbal declarative memory; CESC cis rs7727544 0.735 rs274566 chr5:131715011 A/G cg07395648 chr5:131743802 NA 0.49 6.55 0.37 2.98e-10 Blood metabolite levels; CESC cis rs1448094 0.791 rs7300340 chr12:86329867 G/T cg02569458 chr12:86230093 RASSF9 0.45 6.43 0.37 5.79e-10 Major depressive disorder; CESC cis rs17826219 0.500 rs117560728 chr17:29070938 A/C cg13385521 chr17:29058706 SUZ12P 0.78 5.47 0.32 1.04e-7 Body mass index; CESC cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg19052272 chr2:3704530 ALLC -0.48 -5.97 -0.34 7.67e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs6867032 0.917 rs10474733 chr5:2004160 A/G cg26168224 chr5:2018326 NA -0.83 -13.67 -0.64 1.5e-32 Gut microbiome composition (winter); CESC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg08859206 chr1:53392774 SCP2 0.6 8.86 0.48 1.2e-16 Monocyte count; CESC cis rs250677 0.522 rs6872701 chr5:148359086 C/G cg18129178 chr5:148520854 ABLIM3 0.47 5.16 0.3 4.93e-7 Breast cancer; CESC trans rs11098499 1.000 rs6849889 chr4:120186348 A/C cg25214090 chr10:38739885 LOC399744 0.63 8.35 0.46 3.71e-15 Corneal astigmatism; CESC cis rs7932354 0.710 rs10838621 chr11:46851459 C/T cg25783544 chr11:47291846 MADD -0.39 -5.1 -0.3 6.39e-7 Bone mineral density (hip);Bone mineral density; CESC cis rs7605827 0.897 rs1990756 chr2:15616030 C/T cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14377169 chr1:113162381 ST7L;CAPZA1 0.64 6.68 0.38 1.38e-10 Gut microbiome composition (summer); CESC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.58 0.37 2.53e-10 Prudent dietary pattern; CESC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg10691866 chr7:65817282 TPST1 -0.31 -5.04 -0.3 8.79e-7 Aortic root size; CESC cis rs4253772 0.550 rs6008729 chr22:46727428 C/G cg09491104 chr22:46646882 C22orf40 0.46 6.56 0.37 2.74e-10 LDL cholesterol;Cholesterol, total; CESC trans rs6840360 0.571 rs718801 chr4:152549247 C/T cg16197925 chr7:121944282 FEZF1 0.36 6.04 0.35 5.16e-9 Intelligence (multi-trait analysis); CESC cis rs4073582 0.595 rs801739 chr11:65922589 A/G cg14036092 chr11:66035641 RAB1B 0.53 7.2 0.4 6.4e-12 Gout; CESC cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.6e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs708547 0.874 rs781551 chr4:57718406 A/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.5 -5.44 -0.32 1.2e-7 Response to bleomycin (chromatid breaks); CESC cis rs4588572 0.643 rs2012562 chr5:77768088 T/A cg11547950 chr5:77652471 NA -0.42 -5.26 -0.31 2.96e-7 Triglycerides; CESC cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg18357645 chr12:58087776 OS9 -0.43 -5.98 -0.34 7.09e-9 Multiple sclerosis; CESC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.94 14.58 0.67 9.63e-36 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04958845 chr8:101170202 SPAG1 -0.46 -6.15 -0.35 2.85e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs546131 0.928 rs546521 chr11:34824773 G/C cg11058730 chr11:34937778 PDHX;APIP 0.52 6.43 0.37 5.85e-10 Lung disease severity in cystic fibrosis; CESC cis rs10779751 0.960 rs11121712 chr1:11320329 G/C cg08854313 chr1:11322531 MTOR 0.91 14.45 0.66 2.77e-35 Body mass index; CESC cis rs854765 0.583 rs4925126 chr17:17798633 C/T cg16928487 chr17:17741425 SREBF1 -0.51 -8.52 -0.46 1.22e-15 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26684574 chr20:48532295 SPATA2 0.72 8.32 0.46 4.62e-15 Gut microbiome composition (summer); CESC cis rs80282103 0.618 rs11819230 chr10:1128812 A/G cg08668510 chr10:1095578 IDI1 0.72 5.72 0.33 2.85e-8 Glomerular filtration rate (creatinine); CESC cis rs3820068 0.581 rs72645877 chr1:15928106 G/T cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs1401999 0.659 rs4912518 chr3:183752027 C/T cg01324343 chr3:183735012 ABCC5 -0.5 -8.46 -0.46 1.79e-15 Anterior chamber depth; CESC cis rs6570726 0.935 rs407721 chr6:145871354 A/C cg23711669 chr6:146136114 FBXO30 0.8 11.92 0.59 1.67e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.791 rs1426661 chr4:98874303 C/G cg17366294 chr4:99064904 C4orf37 0.55 7.68 0.43 2.99e-13 Colonoscopy-negative controls vs population controls; CESC cis rs2832191 0.716 rs1888440 chr21:30454484 C/T cg08807101 chr21:30365312 RNF160 0.94 14.55 0.67 1.17e-35 Dental caries; CESC cis rs17431357 1.000 rs76181214 chr12:121013785 T/C cg25045489 chr12:120971538 RNF10 -0.9 -5.23 -0.31 3.44e-7 Insulin resistance/response; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg04590956 chr2:70057467 GMCL1 -0.55 -6.03 -0.35 5.42e-9 Lung cancer in ever smokers; CESC cis rs818427 0.593 rs2545170 chr5:112204170 G/A cg07820702 chr5:112228657 REEP5 0.41 5.52 0.32 7.91e-8 Total body bone mineral density; CESC cis rs763121 0.853 rs3747170 chr22:39067331 G/A cg06022373 chr22:39101656 GTPBP1 0.87 13.83 0.65 4.07e-33 Menopause (age at onset); CESC cis rs3857536 0.842 rs2188590 chr6:66939534 A/G cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs11711311 0.955 rs12630791 chr3:113387717 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.54 -6.94 -0.39 3e-11 IgG glycosylation; CESC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg08704250 chr15:31115839 NA -0.64 -8.54 -0.46 1.05e-15 Huntington's disease progression; CESC cis rs11051970 0.546 rs11051989 chr12:32560890 A/G cg24626660 chr12:32551988 NA 0.36 5.2 0.3 4.09e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs372883 0.648 rs1153288 chr21:30686091 A/G cg24692254 chr21:30365293 RNF160 0.53 6.74 0.38 9.73e-11 Pancreatic cancer; CESC trans rs6445797 0.821 rs6445806 chr3:56670306 T/C cg15444621 chr13:113611794 NA 0.32 6.01 0.35 6.11e-9 Gastritis; CESC cis rs77741769 0.571 rs12822123 chr12:121298644 C/T cg02419362 chr12:121203948 SPPL3 0.34 5.59 0.32 5.6e-8 Mean corpuscular volume; CESC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg11764359 chr7:65958608 NA 0.79 9.51 0.5 1.18e-18 Aortic root size; CESC cis rs3820068 0.603 rs72647118 chr1:15956535 G/T cg17385448 chr1:15911702 AGMAT 0.43 6.93 0.39 3.22e-11 Systolic blood pressure; CESC cis rs2415984 0.622 rs61993296 chr14:46934216 C/T cg14871534 chr14:47121158 RPL10L -0.35 -5.31 -0.31 2.37e-7 Number of children ever born; CESC cis rs6963495 0.745 rs55906043 chr7:105165367 T/G cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg25072359 chr17:41440525 NA 0.44 5.89 0.34 1.16e-8 Menopause (age at onset); CESC cis rs7122539 0.646 rs608248 chr11:66562248 C/T cg24851651 chr11:66362959 CCS -0.5 -7.36 -0.41 2.37e-12 HIV-1 susceptibility; CESC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg08470875 chr2:26401718 FAM59B 0.67 6.96 0.39 2.72e-11 Gut microbiome composition (summer); CESC cis rs12928939 0.517 rs12445641 chr16:71967783 C/T cg03805757 chr16:71968109 PKD1L3 -0.59 -6.62 -0.38 2.01e-10 Post bronchodilator FEV1; CESC cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg20476274 chr7:133979776 SLC35B4 0.65 9.4 0.5 2.68e-18 Mean platelet volume; CESC cis rs6460942 0.597 rs12699381 chr7:12527026 G/A cg02935154 chr7:12443704 VWDE -0.55 -5.58 -0.32 6.01e-8 Coronary artery disease; CESC trans rs11098499 0.789 rs1980024 chr4:120253047 C/T cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs3091242 0.933 rs28530483 chr1:25740847 A/C cg12412775 chr1:25698385 RHCE -0.29 -5.11 -0.3 6.12e-7 Erythrocyte sedimentation rate; CESC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg27266027 chr21:40555129 PSMG1 0.4 5.1 0.3 6.35e-7 Cognitive function; CESC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg06505273 chr16:24850292 NA 0.51 6.32 0.36 1.09e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg13206674 chr6:150067644 NUP43 0.42 5.89 0.34 1.19e-8 Lung cancer; CESC cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg05283184 chr6:79620031 NA 0.46 7.01 0.4 2e-11 Intelligence (multi-trait analysis); CESC cis rs9811920 0.529 rs793442 chr3:99581062 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.52 -6.35 -0.36 9.49e-10 Axial length; CESC cis rs12541635 0.966 rs7819043 chr8:106989783 T/C cg10147462 chr8:107024639 NA 0.37 5.14 0.3 5.44e-7 Age of smoking initiation; CESC cis rs1915146 0.546 rs2681919 chr10:126859029 A/G cg17191109 chr10:126851326 NA 0.41 6.6 0.38 2.29e-10 Menarche (age at onset); CESC cis rs7605827 0.780 rs2287279 chr2:15667778 G/A cg19274914 chr2:15703543 NA 0.38 6.69 0.38 1.34e-10 Educational attainment (years of education); CESC cis rs400736 0.859 rs379920 chr1:8028865 G/C cg25007680 chr1:8021821 PARK7 0.72 10.16 0.53 1.11e-20 Response to antidepressants and depression; CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.45 -5.59 -0.32 5.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.532 rs4401299 chr22:42156517 A/G cg06481639 chr22:41940642 POLR3H 0.5 5.81 0.34 1.78e-8 Vitiligo; CESC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg07343612 chr16:622815 PIGQ -0.55 -8.08 -0.44 2.32e-14 Height; CESC cis rs7100689 0.622 rs7897994 chr10:82133304 T/G cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg21226059 chr5:178986404 RUFY1 0.49 7.29 0.41 3.49e-12 Lung cancer; CESC cis rs3020736 0.500 rs9620026 chr22:42498578 C/T cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC cis rs7937682 0.855 rs490897 chr11:111487914 A/G cg09085632 chr11:111637200 PPP2R1B -0.94 -14.45 -0.66 2.76e-35 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18844589 chr2:238707052 RBM44 -0.52 -6.05 -0.35 4.88e-9 Gut microbiome composition (summer); CESC cis rs4642101 0.662 rs57411588 chr3:12820384 C/G cg05775895 chr3:12838266 CAND2 0.41 6.36 0.36 8.94e-10 QRS complex (12-leadsum); CESC cis rs10779751 0.734 rs2791653 chr1:11129848 A/G cg08854313 chr1:11322531 MTOR 0.74 9.19 0.49 1.16e-17 Body mass index; CESC cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg00701064 chr4:6280414 WFS1 0.62 10.21 0.53 7.39e-21 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.45e-30 Colonoscopy-negative controls vs population controls; CESC cis rs79349575 0.783 rs832410 chr17:46972865 C/T cg16584676 chr17:46985605 UBE2Z 0.54 6.6 0.38 2.26e-10 Type 2 diabetes; CESC cis rs1050631 0.564 rs12185396 chr18:33738496 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.6 8.08 0.44 2.32e-14 Esophageal squamous cell cancer (length of survival); CESC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg03388025 chr16:89894329 SPIRE2 0.41 8.11 0.45 1.94e-14 Vitiligo; CESC cis rs367943 0.712 rs26967 chr5:112741467 C/G cg12552261 chr5:112820674 MCC 0.4 5.32 0.31 2.17e-7 Type 2 diabetes; CESC cis rs11250464 0.833 rs11250467 chr10:1409662 A/G cg08668359 chr10:1443807 ADARB2 0.59 7.3 0.41 3.35e-12 Radiation response; CESC cis rs11785400 0.793 rs4301430 chr8:143737416 A/G cg24634471 chr8:143751801 JRK 0.44 5.48 0.32 1.01e-7 Schizophrenia; CESC cis rs11577318 0.853 rs1071849 chr1:26646726 A/G cg00813993 chr1:26644493 UBXN11;CD52 -0.4 -6.36 -0.36 8.77e-10 Granulocyte percentage of myeloid white cells; CESC cis rs10751667 1.000 rs4074232 chr11:977682 C/G cg06064525 chr11:970664 AP2A2 -0.38 -6.75 -0.38 9.49e-11 Alzheimer's disease (late onset); CESC cis rs4660306 1.000 rs6429569 chr1:46001330 A/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.2 -0.36 2.1e-9 Homocysteine levels; CESC cis rs7044106 0.762 rs10760112 chr9:123467570 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.72 10.74 0.55 1.42e-22 Hip circumference adjusted for BMI; CESC cis rs9355610 0.609 rs62436424 chr6:167374258 A/G cg23791538 chr6:167370224 RNASET2 0.5 5.89 0.34 1.16e-8 Graves' disease; CESC cis rs959260 1.000 rs2891713 chr17:73386622 G/C cg20590849 chr17:73267439 MIF4GD -0.55 -6.36 -0.36 8.61e-10 Systemic lupus erythematosus; CESC cis rs2066819 0.892 rs17118431 chr12:56667100 A/G cg26734620 chr12:56694298 CS 1.04 6.71 0.38 1.18e-10 Psoriasis vulgaris; CESC cis rs3806843 0.735 rs3776129 chr5:140072292 G/A cg26395211 chr5:140044315 WDR55 0.47 5.95 0.34 8.29e-9 Depressive symptoms (multi-trait analysis); CESC cis rs9325144 0.624 rs10506126 chr12:39123244 G/A cg26384229 chr12:38710491 ALG10B -0.53 -7.27 -0.41 4.14e-12 Morning vs. evening chronotype; CESC cis rs7833790 1.000 rs28696138 chr8:82770794 G/A cg07697082 chr8:82753677 SNX16 -0.39 -5.32 -0.31 2.19e-7 Diastolic blood pressure; CESC cis rs2262909 0.962 rs1526884 chr19:22303651 A/G cg11619707 chr19:22235551 ZNF257 0.33 5.29 0.31 2.51e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg07507251 chr3:52567010 NT5DC2 0.34 5.92 0.34 9.68e-9 Bipolar disorder; CESC cis rs11587400 0.679 rs12090305 chr1:115109441 G/A cg12756093 chr1:115239321 AMPD1 0.43 5.76 0.33 2.27e-8 Autism; CESC cis rs950027 0.620 rs1145080 chr15:45681338 C/T cg21132104 chr15:45694354 SPATA5L1 0.67 8.55 0.46 1.01e-15 Response to fenofibrate (adiponectin levels); CESC cis rs6582630 0.519 rs8186992 chr12:38325848 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.68 0.33 3.51e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs6088590 1.000 rs2236270 chr20:33523155 G/T cg24642439 chr20:33292090 TP53INP2 0.87 11.98 0.59 1.02e-26 Coronary artery disease; CESC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg13628971 chr7:2884303 GNA12 0.65 9.14 0.49 1.69e-17 Height; CESC trans rs2235573 0.527 rs139862 chr22:38351986 T/C cg19894588 chr14:64061835 NA 0.63 8.28 0.45 6.09e-15 Glioblastoma;Glioma; CESC cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg22875332 chr1:76189707 ACADM 0.59 6.01 0.35 5.96e-9 Blood metabolite levels;Acylcarnitine levels; CESC trans rs1814175 0.791 rs11040472 chr11:49703116 C/T cg03929089 chr4:120376271 NA -0.92 -15.12 -0.68 1.14e-37 Height; CESC trans rs5417 0.775 rs222852 chr17:7140606 A/G cg15655154 chr3:113604241 GRAMD1C 0.5 6.85 0.39 5.02e-11 Diastolic blood pressure; CESC cis rs6460942 0.591 rs62448729 chr7:12333720 G/C cg02935154 chr7:12443704 VWDE -0.53 -5.5 -0.32 9.01e-8 Coronary artery disease; CESC trans rs7824557 0.545 rs2736303 chr8:11236850 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -6.16 -0.35 2.7e-9 Retinal vascular caliber; CESC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg24562669 chr7:97807699 LMTK2 -0.51 -7.5 -0.42 9.77e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs889398 0.802 rs12919094 chr16:69843357 A/G cg09409435 chr16:70099608 PDXDC2 -0.42 -5.3 -0.31 2.44e-7 Body mass index; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg09247696 chr2:74756297 HTRA2;AUP1 -0.4 -6.18 -0.35 2.39e-9 Vertical cup-disc ratio; CESC cis rs870825 0.655 rs10033035 chr4:185630880 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.0 0.4 2.05e-11 Blood protein levels; CESC cis rs1030268 0.715 rs13235840 chr7:133505091 A/T cg10665199 chr7:133106180 EXOC4 0.54 5.38 0.31 1.63e-7 Intelligence (multi-trait analysis); CESC cis rs929596 0.574 rs75444879 chr2:234587848 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -5.34 -0.31 2.01e-7 Total bilirubin levels in HIV-1 infection; CESC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs2066819 0.786 rs116934693 chr12:56696545 T/G cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs7212590 0.618 rs35806089 chr17:57943906 A/G cg20303301 chr17:57937339 TUBD1 -0.53 -5.25 -0.31 3.06e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17309711 chr11:45826527 SLC35C1 0.46 6.1 0.35 3.72e-9 Gut microbiota (bacterial taxa); CESC cis rs761746 0.920 rs5998011 chr22:31889566 T/C cg25791279 chr22:32026902 PISD -0.5 -5.57 -0.32 6.25e-8 Intelligence; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg13094338 chr20:62258937 GMEB2 -0.5 -6.75 -0.38 9.08e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs11645898 0.872 rs72787070 chr16:72151101 T/C cg14768367 chr16:72042858 DHODH -0.75 -6.38 -0.37 7.71e-10 Blood protein levels; CESC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg08888203 chr3:10149979 C3orf24 0.46 5.94 0.34 8.69e-9 Alzheimer's disease; CESC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.5 -0.37 4e-10 Electroencephalogram traits; CESC cis rs1707322 0.721 rs7519900 chr1:46234947 C/T cg03146154 chr1:46216737 IPP 0.82 11.5 0.58 4.28e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14247862 chr17:80764631 TBCD -0.55 -6.37 -0.36 8.38e-10 Gut microbiome composition (summer); CESC cis rs3020736 0.500 rs8143153 chr22:42515637 G/C cg15557168 chr22:42548783 NA 0.44 6.2 0.36 2.18e-9 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07604202 chr20:50701378 ZFP64 -0.59 -7.02 -0.4 1.87e-11 Gut microbiome composition (summer); CESC cis rs74781061 0.929 rs8029215 chr15:74853488 A/G cg17294928 chr15:75287854 SCAMP5 -0.49 -5.24 -0.31 3.28e-7 Endometriosis; CESC cis rs9905704 0.647 rs7221274 chr17:57008128 A/G cg12560992 chr17:57184187 TRIM37 0.62 7.8 0.43 1.47e-13 Testicular germ cell tumor; CESC trans rs11250097 0.535 rs11250086 chr8:10769783 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.08 -0.35 4.28e-9 Neuroticism; CESC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg05025164 chr4:1340916 KIAA1530 0.51 7.0 0.39 2.14e-11 Longevity; CESC cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg24110177 chr3:50126178 RBM5 0.58 8.17 0.45 1.28e-14 Body mass index; CESC cis rs10465746 0.905 rs12738214 chr1:84359050 C/A cg10977910 chr1:84465055 TTLL7 0.48 6.34 0.36 9.89e-10 Obesity-related traits; CESC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 13.46 0.64 8.33e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7615952 0.673 rs3811677 chr3:125648080 G/A cg07211511 chr3:129823064 LOC729375 -1.13 -15.13 -0.68 1.07e-37 Blood pressure (smoking interaction); CESC cis rs8060686 0.920 rs56047901 chr16:67742326 G/A cg26727032 chr16:67993705 SLC12A4 -0.57 -6.0 -0.35 6.41e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs11711311 0.824 rs9833810 chr3:113363762 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.65 8.27 0.45 6.63e-15 IgG glycosylation; CESC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14161438 chr18:72920197 ZADH2 -0.7 -8.55 -0.46 9.74e-16 Gut microbiome composition (summer); CESC cis rs11997175 0.574 rs9642707 chr8:33645789 C/G ch.8.33884649F chr8:33765107 NA 0.68 8.99 0.48 4.7e-17 Body mass index; CESC cis rs12142240 0.692 rs7532149 chr1:46824932 A/C cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC trans rs330048 0.561 rs330088 chr8:9149746 T/C cg15556689 chr8:8085844 FLJ10661 0.58 7.6 0.42 5.26e-13 Systemic lupus erythematosus; CESC cis rs2250402 0.510 rs2291619 chr15:40329033 C/T cg10636054 chr15:40330586 SRP14 -0.85 -6.58 -0.37 2.49e-10 Corneal curvature; CESC cis rs11650494 0.634 rs8072520 chr17:47466640 T/G cg08112188 chr17:47440006 ZNF652 0.86 6.32 0.36 1.11e-9 Prostate cancer; CESC cis rs9868809 0.881 rs2276852 chr3:48666923 A/G cg07636037 chr3:49044803 WDR6 -0.65 -6.08 -0.35 4.25e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg00522288 chr12:125625016 AACS 0.33 5.25 0.31 3.06e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs4704187 0.687 rs6453123 chr5:74519049 G/A cg03227963 chr5:74354835 NA 0.28 5.04 0.3 8.66e-7 Response to amphetamines; CESC cis rs8067545 0.611 rs8078716 chr17:20044291 G/A cg13482628 chr17:19912719 NA 0.4 5.37 0.31 1.75e-7 Schizophrenia; CESC cis rs2228479 0.557 rs2293584 chr16:89888686 C/G cg14709524 chr16:89940631 TCF25 0.87 6.05 0.35 4.99e-9 Skin colour saturation; CESC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg16262614 chr3:133464971 TF 0.3 5.33 0.31 2.14e-7 Iron status biomarkers; CESC cis rs4822044 0.617 rs13054514 chr22:42130383 A/G cg06481639 chr22:41940642 POLR3H 0.5 5.81 0.34 1.78e-8 Cannabis dependence symptom count; CESC cis rs11785400 0.793 rs2978973 chr8:143747271 C/G cg10596483 chr8:143751796 JRK 0.47 5.75 0.33 2.46e-8 Schizophrenia; CESC cis rs12618769 0.597 rs2278212 chr2:99136266 T/C cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05221349 chr4:100870488 LOC256880;H2AFZ -0.44 -6.27 -0.36 1.47e-9 Ulcerative colitis; CESC cis rs7247513 1.000 rs7247513 chr19:12691185 C/T cg01871581 chr19:12707946 ZNF490 -0.87 -15.08 -0.68 1.59e-37 Bipolar disorder; CESC trans rs1814175 0.617 rs6486020 chr11:49769149 T/G cg03929089 chr4:120376271 NA -0.89 -13.67 -0.64 1.51e-32 Height; CESC cis rs7619708 1 rs7619708 chr3:195810187 T/C cg01181863 chr3:195395398 SDHAP2 0.66 6.55 0.37 2.91e-10 Red cell distribution width; CESC cis rs2191566 0.664 rs7254261 chr19:44565427 A/G cg20607764 chr19:44506953 ZNF230 -0.41 -5.35 -0.31 1.93e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs1461503 0.900 rs7110039 chr11:122834001 C/T cg27398637 chr11:122830231 C11orf63 0.59 9.1 0.49 2.19e-17 Menarche (age at onset); CESC cis rs2777491 0.574 rs11635906 chr15:41779260 A/G cg18705301 chr15:41695430 NDUFAF1 -1.06 -16.0 -0.7 8.47e-41 Ulcerative colitis; CESC cis rs7845219 0.544 rs10956932 chr8:95948202 C/T cg16049864 chr8:95962084 TP53INP1 0.4 5.79 0.34 1.95e-8 Type 2 diabetes; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12133393 chr1:3816695 C1orf174;LOC100133612 -0.46 -6.01 -0.35 6.06e-9 Ulcerative colitis; CESC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg08859206 chr1:53392774 SCP2 -0.67 -9.83 -0.52 1.23e-19 Monocyte count; CESC cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg12292205 chr6:26970375 C6orf41 -0.47 -5.25 -0.31 3.15e-7 Intelligence (multi-trait analysis); CESC cis rs72945132 0.882 rs2276001 chr11:70181560 T/C cg14191688 chr11:70257035 CTTN 0.43 5.41 0.32 1.39e-7 Coronary artery disease; CESC cis rs722599 0.651 rs12887044 chr14:75255659 C/T cg11812906 chr14:75593930 NEK9 0.45 5.48 0.32 9.8e-8 IgG glycosylation; CESC cis rs4555082 0.830 rs2816648 chr14:105708289 C/T cg10792982 chr14:105748885 BRF1 0.4 5.03 0.3 9.04e-7 Mean platelet volume;Platelet distribution width; CESC cis rs10214930 0.697 rs6942908 chr7:27905918 G/A cg05786569 chr7:27702416 HIBADH 0.46 5.49 0.32 9.56e-8 Hypospadias; CESC cis rs3806843 1.000 rs2879089 chr5:140191893 A/T cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.11 -0.3 6.18e-7 Depressive symptoms (multi-trait analysis); CESC trans rs7786808 0.712 rs2335170 chr7:158207101 G/A cg03441993 chr4:55093323 NA 0.4 6.06 0.35 4.59e-9 Obesity-related traits; CESC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg23048001 chr7:2026167 MAD1L1 0.46 6.09 0.35 3.99e-9 Autism spectrum disorder or schizophrenia; CESC cis rs6499255 0.951 rs12595869 chr16:69729794 T/G cg15192750 chr16:69999425 NA 0.52 6.0 0.35 6.51e-9 IgE levels; CESC cis rs1577917 1.000 rs1577919 chr6:86757296 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.01 -0.35 5.96e-9 Response to antipsychotic treatment; CESC cis rs919433 0.783 rs55725278 chr2:198238223 C/T cg20885578 chr2:198174922 NA 0.4 5.35 0.31 1.88e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs7762018 0.891 rs3088346 chr6:170149793 T/C cg13891659 chr6:170190454 C6orf122;C6orf208 0.65 6.35 0.36 9.55e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6964587 1.000 rs6946356 chr7:91727385 G/A cg17063962 chr7:91808500 NA 0.56 7.73 0.43 2.31e-13 Breast cancer; CESC cis rs796364 0.806 rs76112266 chr2:201087157 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.76 -6.63 -0.38 1.84e-10 Schizophrenia; CESC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg10150615 chr22:24372951 LOC391322 -0.55 -7.31 -0.41 3.06e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg16144293 chr14:75469539 EIF2B2 -0.4 -5.32 -0.31 2.22e-7 Height; CESC cis rs72781680 0.898 rs55657921 chr2:24008091 C/G cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs796364 0.806 rs11688168 chr2:200916004 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg10295955 chr4:187884368 NA -0.98 -17.53 -0.73 3.27e-46 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00566492 chr22:39096679 JOSD1 0.56 6.25 0.36 1.62e-9 Gut microbiome composition (summer); CESC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg09060608 chr5:178986726 RUFY1 -0.55 -8.6 -0.47 7.21e-16 Lung cancer; CESC cis rs10504073 0.647 rs341807 chr8:50032676 C/T cg00325661 chr8:49890786 NA 0.51 7.5 0.42 9.61e-13 Blood metabolite ratios; CESC trans rs11098499 0.954 rs11098525 chr4:120390152 G/A cg25214090 chr10:38739885 LOC399744 0.71 10.34 0.54 2.77e-21 Corneal astigmatism; CESC cis rs654950 0.967 rs621727 chr1:41984612 C/T cg06885757 chr1:42089581 HIVEP3 -0.53 -7.9 -0.44 7.69e-14 Airway imaging phenotypes; CESC cis rs72945132 1.000 rs72945129 chr11:70110808 C/T cg14191688 chr11:70257035 CTTN 0.42 5.1 0.3 6.56e-7 Coronary artery disease; CESC cis rs7208859 0.573 rs8064686 chr17:29134839 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg04090027 chr2:97760622 FAHD2B -0.45 -7.0 -0.4 2.11e-11 Vertical cup-disc ratio; CESC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.03 -11.57 -0.58 2.49e-25 Gut microbiome composition (summer); CESC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.43 -5.42 -0.32 1.34e-7 Tonsillectomy; CESC cis rs10851478 0.558 rs4389093 chr15:49743069 A/G cg08060515 chr15:49448048 GALK2;COPS2 0.5 6.35 0.36 9.27e-10 Oral cavity cancer; CESC cis rs9894429 0.789 rs7219915 chr17:79591813 C/T cg21984481 chr17:79567631 NPLOC4 -0.56 -8.99 -0.48 4.98e-17 Eye color traits; CESC cis rs1577917 1.000 rs1577917 chr6:86691940 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.51 -6.46 -0.37 4.93e-10 Response to antipsychotic treatment; CESC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.49 -6.54 -0.37 3.08e-10 Bipolar disorder; CESC cis rs9837602 1.000 rs9878931 chr3:99712634 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 7.24 0.41 4.82e-12 Breast cancer; CESC cis rs67311347 0.544 rs4974040 chr3:40331059 G/A cg09455208 chr3:40491958 NA 0.35 6.24 0.36 1.68e-9 Renal cell carcinoma; CESC cis rs1355223 0.506 rs11032899 chr11:34870234 G/A cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.64 -0.38 1.81e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs72945132 0.882 rs7943547 chr11:70133282 C/A cg14191688 chr11:70257035 CTTN 0.41 5.19 0.3 4.24e-7 Coronary artery disease; CESC trans rs7246657 0.943 rs1382357 chr19:37977609 G/A cg24637308 chr11:6592297 DNHD1 0.53 6.13 0.35 3.16e-9 Coronary artery calcification; CESC cis rs7824557 0.583 rs2263512 chr8:11233419 T/G cg21775007 chr8:11205619 TDH -0.55 -8.22 -0.45 9.13e-15 Retinal vascular caliber; CESC cis rs863345 0.604 rs1873510 chr1:158461418 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -7.17 -0.4 7.58e-12 Pneumococcal bacteremia; CESC cis rs2562784 0.597 rs2562785 chr15:84286021 G/T cg17507749 chr15:85114479 UBE2QP1 0.57 5.37 0.31 1.74e-7 Height; CESC cis rs7178572 0.568 rs3743478 chr15:77400388 T/C cg22256960 chr15:77711686 NA -0.53 -6.65 -0.38 1.69e-10 Type 2 diabetes; CESC cis rs6674176 0.660 rs6680421 chr1:44408969 A/C cg12908607 chr1:44402522 ARTN 0.49 7.42 0.41 1.63e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs6677604 1.000 rs16840639 chr1:196824773 T/C cg02859443 chr16:53737878 RPGRIP1L;FTO -0.62 -6.07 -0.35 4.34e-9 IgA nephropathy;Nephropathy;Blood protein levels; CESC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC trans rs1814175 0.616 rs847641 chr11:49919261 T/C cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs8017423 0.765 rs8017170 chr14:90721849 T/A cg14092571 chr14:90743983 NA -0.55 -8.31 -0.45 5.07e-15 Mortality in heart failure; CESC cis rs2228479 0.850 rs11640188 chr16:89807732 C/T cg06558623 chr16:89946397 TCF25 1.15 9.22 0.49 9.66e-18 Skin colour saturation; CESC cis rs10504073 0.647 rs2292399 chr8:49987230 A/G cg00325661 chr8:49890786 NA 0.55 8.17 0.45 1.29e-14 Blood metabolite ratios; CESC cis rs10504229 0.871 rs56048296 chr8:58163781 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -5.41 -0.32 1.43e-7 Developmental language disorder (linguistic errors); CESC cis rs7799006 0.691 rs10447541 chr7:2301578 T/G cg12745145 chr7:2261452 MAD1L1 -0.33 -5.22 -0.31 3.56e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9611565 0.649 rs139540 chr22:42178040 C/T cg03806693 chr22:41940476 POLR3H -0.8 -9.68 -0.51 3.51e-19 Vitiligo; CESC cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg20476274 chr7:133979776 SLC35B4 0.64 9.32 0.5 4.57e-18 Mean platelet volume; CESC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg19717773 chr7:2847554 GNA12 -0.47 -6.75 -0.38 9.38e-11 Height; CESC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg23281280 chr6:28129359 ZNF389 0.59 8.16 0.45 1.34e-14 Depression; CESC cis rs1707322 1.000 rs4660336 chr1:46487976 T/C cg03146154 chr1:46216737 IPP -0.71 -9.69 -0.51 3.37e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11252926 0.801 rs12358553 chr10:558014 C/T cg18196295 chr10:418757 DIP2C -0.48 -5.71 -0.33 3.02e-8 Psychosis in Alzheimer's disease; CESC cis rs9549367 0.713 rs2476319 chr13:113836519 C/T cg18105134 chr13:113819100 PROZ 0.55 7.12 0.4 1.04e-11 Platelet distribution width; CESC cis rs7264396 1.000 rs224435 chr20:34154087 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.04 -0.35 5.27e-9 Total cholesterol levels; CESC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg18350739 chr11:68623251 NA -0.38 -5.7 -0.33 3.14e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs2742417 0.603 rs9826208 chr3:45773991 C/T cg04837898 chr3:45731254 SACM1L -0.46 -6.11 -0.35 3.5e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg06221963 chr1:154839813 KCNN3 0.72 12.47 0.61 2.13e-28 Prostate cancer; CESC cis rs6088590 1.000 rs2295353 chr20:33356511 C/T cg24642439 chr20:33292090 TP53INP2 0.86 11.84 0.59 3.04e-26 Coronary artery disease; CESC cis rs6800768 0.633 rs57903454 chr3:24092407 A/T cg10674438 chr3:24145617 LOC152024 -0.42 -5.69 -0.33 3.32e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg00106254 chr7:1943704 MAD1L1 -0.48 -6.09 -0.35 4.03e-9 Bipolar disorder and schizophrenia; CESC cis rs782590 0.967 rs2627759 chr2:55853341 T/C cg18811423 chr2:55921094 PNPT1 0.83 13.52 0.64 4.95e-32 Metabolic syndrome; CESC cis rs1595825 0.628 rs6760078 chr2:198563742 A/T cg00982548 chr2:198649783 BOLL -0.52 -5.82 -0.34 1.73e-8 Ulcerative colitis; CESC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.11 -0.3 6.3e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs763121 0.785 rs5750646 chr22:39013830 T/C cg06022373 chr22:39101656 GTPBP1 0.95 17.28 0.73 2.5e-45 Menopause (age at onset); CESC trans rs9325144 0.647 rs12227834 chr12:38849246 G/C cg23762105 chr12:34175262 ALG10 0.46 6.04 0.35 5.3e-9 Morning vs. evening chronotype; CESC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg23034840 chr1:205782522 SLC41A1 0.75 9.71 0.51 2.83e-19 Prostate-specific antigen levels; CESC cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg19717773 chr7:2847554 GNA12 -0.52 -8.07 -0.44 2.43e-14 Height; CESC trans rs61931739 0.929 rs10844748 chr12:34092930 G/T cg26384229 chr12:38710491 ALG10B -0.47 -6.57 -0.37 2.71e-10 Morning vs. evening chronotype; CESC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg19077165 chr18:44547161 KATNAL2 -0.62 -9.41 -0.5 2.43e-18 Personality dimensions; CESC cis rs3747547 0.892 rs72726029 chr9:38032868 C/T cg13774184 chr9:37916125 SHB -0.72 -6.04 -0.35 5.24e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs9682041 1.000 rs6773095 chr3:170082181 A/G cg11886554 chr3:170076028 SKIL 1.05 8.52 0.46 1.25e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.76e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4727027 0.704 rs12537763 chr7:148903984 G/A cg23583168 chr7:148888333 NA -0.93 -17.07 -0.72 1.37e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg04772025 chr11:68637568 NA 0.56 6.57 0.37 2.6200000000000003e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11723261 0.582 rs11732336 chr4:140512 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.49 6.21 0.36 1.99e-9 Immune response to smallpox vaccine (IL-6); CESC cis rs9513593 1.000 rs9585040 chr13:100015539 T/C cg21788972 chr13:99853209 UBAC2 0.69 7.6 0.42 5.03e-13 Psoriasis; CESC cis rs1975974 0.511 rs56047890 chr17:21733405 G/A cg18423549 chr17:21743878 NA -0.62 -8.74 -0.47 2.81e-16 Psoriasis; CESC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg23172400 chr8:95962367 TP53INP1 -0.5 -10.43 -0.54 1.43e-21 Type 2 diabetes; CESC cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 10.65 0.55 2.82e-22 Eosinophil percentage of white cells; CESC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg11663144 chr21:46675770 NA -0.62 -9.78 -0.51 1.79e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs265548 0.646 rs36689 chr19:17910639 A/G cg16024904 chr19:17905718 B3GNT3 0.43 5.73 0.33 2.74e-8 Tumor biomarkers; CESC cis rs11864453 0.826 rs12448315 chr16:72147242 G/T cg16558253 chr16:72132732 DHX38 -0.61 -9.68 -0.51 3.71e-19 Fibrinogen levels; CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg17178900 chr1:205818956 PM20D1 -0.66 -10.93 -0.56 3.48e-23 Monocyte percentage of white cells; CESC cis rs4901847 0.562 rs11628678 chr14:58611623 A/C cg15908186 chr14:58618357 C14orf37 0.36 5.38 0.31 1.61e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs7216064 1.000 rs11079706 chr17:65835470 G/T cg12091567 chr17:66097778 LOC651250 -0.86 -8.83 -0.48 1.49e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs1799949 0.965 rs8070179 chr17:41202688 G/A cg05368731 chr17:41323189 NBR1 0.5 6.86 0.39 4.72e-11 Menopause (age at onset); CESC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg26338869 chr17:61819248 STRADA 0.67 8.77 0.47 2.24e-16 Prudent dietary pattern; CESC cis rs3126085 0.867 rs12748016 chr1:152197235 T/C cg03465714 chr1:152285911 FLG 0.44 5.25 0.31 3.15e-7 Atopic dermatitis; CESC trans rs1814175 0.616 rs1794131 chr11:49904194 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs6572548 0.504 rs1956082 chr14:49665496 A/C cg13402779 chr14:50101323 C14orf104 -0.47 -5.23 -0.31 3.49e-7 Subjective well-being; CESC cis rs7208859 0.673 rs216435 chr17:28922737 G/T cg17105886 chr17:28927953 LRRC37B2 0.62 5.48 0.32 1.01e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg26939375 chr7:64535504 NA -0.75 -10.64 -0.55 2.96e-22 Corneal structure; CESC cis rs131777 0.708 rs131749 chr22:51024624 C/T cg00083937 chr22:51039805 MAPK8IP2 -0.4 -5.66 -0.33 3.88e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg07648498 chr16:89883185 FANCA 0.51 6.41 0.37 6.66e-10 Vitiligo; CESC trans rs9650657 0.529 rs10108618 chr8:10953092 A/G cg15556689 chr8:8085844 FLJ10661 -0.48 -6.18 -0.35 2.46e-9 Neuroticism; CESC cis rs2066819 1.000 rs59811639 chr12:56695954 C/T cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs1003719 0.667 rs28666643 chr21:38455999 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 6.57 0.37 2.58e-10 Eye color traits; CESC cis rs12477438 0.765 rs7340412 chr2:99661148 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg18876405 chr7:65276391 NA 0.49 6.54 0.37 3.11e-10 Aortic root size; CESC cis rs34779708 0.931 rs3740083 chr10:35320383 C/T cg04310649 chr10:35416472 CREM -0.51 -6.24 -0.36 1.76e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs10791097 1.000 rs10791098 chr11:130718711 T/G cg12179176 chr11:130786555 SNX19 0.58 8.39 0.46 2.91e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs3749237 0.595 rs7621003 chr3:49411404 T/C cg07636037 chr3:49044803 WDR6 0.62 8.98 0.48 5.18e-17 Resting heart rate; CESC cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg00255919 chr5:131827918 IRF1 -0.35 -5.11 -0.3 6.23e-7 Breast cancer;Mosquito bite size; CESC cis rs7208859 0.623 rs11650271 chr17:29213943 C/T cg19761014 chr17:28927070 LRRC37B2 0.73 5.75 0.33 2.39e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1401999 0.966 rs2313212 chr3:183700928 A/G cg01324343 chr3:183735012 ABCC5 0.64 13.52 0.64 5.02e-32 Anterior chamber depth; CESC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg19193384 chr17:30244184 NA 0.49 5.14 0.3 5.37e-7 Hip circumference adjusted for BMI; CESC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg13114125 chr14:105738426 BRF1 -0.8 -9.77 -0.51 1.83e-19 Mean platelet volume;Platelet distribution width; CESC trans rs12478296 0.901 rs67951957 chr2:243004901 A/G cg18288967 chr1:45987694 PRDX1 0.6 6.62 0.38 1.93e-10 Obesity-related traits; CESC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg27170947 chr2:26402098 FAM59B -0.87 -9.89 -0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs9658691 0.607 rs12412701 chr10:90782323 C/T cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -5.34 -0.31 2.05e-7 Mosquito bite size; CESC cis rs9916302 0.861 rs11078913 chr17:37671714 G/T cg00129232 chr17:37814104 STARD3 -0.58 -7.8 -0.43 1.44e-13 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04749066 chr2:192746843 NA -0.76 -9.12 -0.49 1.89e-17 Gut microbiome composition (summer); CESC cis rs1144333 1.000 rs5745392 chr1:76306809 C/T cg10523679 chr1:76189770 ACADM 0.56 5.26 0.31 3.04e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs17608059 0.545 rs736261 chr17:13936404 A/G cg11395062 chr17:14139857 CDRT15 0.46 5.79 0.34 1.99e-8 Temperament; CESC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg17376030 chr22:41985996 PMM1 0.67 7.27 0.41 3.96e-12 Vitiligo; CESC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg08888203 chr3:10149979 C3orf24 0.53 6.72 0.38 1.11e-10 Alzheimer's disease; CESC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg00310523 chr12:86230176 RASSF9 0.41 6.23 0.36 1.85e-9 Major depressive disorder; CESC cis rs2204008 0.628 rs10876106 chr12:37990767 A/G cg26384229 chr12:38710491 ALG10B 0.66 9.47 0.5 1.58e-18 Bladder cancer; CESC cis rs2985684 0.894 rs2354439 chr14:50019417 G/C cg04989706 chr14:50066350 PPIL5 -0.44 -5.06 -0.3 7.85e-7 Carotid intima media thickness; CESC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10323457 chr2:208890222 PLEKHM3 0.55 6.14 0.35 3.08e-9 Gut microbiome composition (summer); CESC cis rs8114671 0.647 rs6060268 chr20:33734293 T/C cg24642439 chr20:33292090 TP53INP2 0.51 6.5 0.37 3.86e-10 Height; CESC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg04414720 chr1:150670196 GOLPH3L 0.61 8.81 0.48 1.72e-16 Tonsillectomy; CESC cis rs7927592 0.763 rs2513277 chr11:68360887 T/G cg20283391 chr11:68216788 NA -0.42 -5.16 -0.3 4.88e-7 Total body bone mineral density; CESC cis rs137603 0.644 rs137619 chr22:39706360 A/C cg01093212 chr22:39715156 SNORD43;RPL3 -0.4 -5.11 -0.3 6.04e-7 Primary biliary cholangitis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg12838843 chr3:141205758 RASA2 -0.5 -6.16 -0.35 2.65e-9 Ulcerative colitis; CESC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg02569458 chr12:86230093 RASSF9 0.49 7.21 0.41 5.78e-12 Major depressive disorder; CESC cis rs7949030 0.588 rs2428548 chr11:62311462 A/G cg13298116 chr11:62369859 EML3;MTA2 0.58 8.57 0.47 8.59e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs7089973 0.872 rs10490908 chr10:116616162 T/C cg25233709 chr10:116636983 FAM160B1 0.35 5.08 0.3 7.02e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2865126 0.779 rs4796905 chr18:10755251 T/C cg21165219 chr18:10698044 FAM38B -0.5 -5.18 -0.3 4.48e-7 Metabolite levels (5-HIAA/ MHPG Ratio); CESC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg06481639 chr22:41940642 POLR3H -0.61 -6.39 -0.37 7.34e-10 Vitiligo; CESC cis rs11997175 0.550 rs6468206 chr8:33780878 A/C ch.8.33884649F chr8:33765107 NA 0.63 7.85 0.43 1e-13 Body mass index; CESC cis rs4588572 0.643 rs1560196 chr5:77701982 G/C cg11547950 chr5:77652471 NA 0.46 5.95 0.34 8.49e-9 Triglycerides; CESC cis rs17376456 0.877 rs34184666 chr5:93444584 T/C cg21475434 chr5:93447410 FAM172A 0.85 7.6 0.42 5.01e-13 Diabetic retinopathy; CESC cis rs3008870 0.701 rs2815358 chr1:67493778 T/C cg02640540 chr1:67518911 SLC35D1 0.44 5.36 0.31 1.84e-7 Lymphocyte percentage of white cells; CESC cis rs6460942 1.000 rs75564554 chr7:12319362 A/C cg06484146 chr7:12443880 VWDE -0.81 -8.78 -0.47 2.13e-16 Coronary artery disease; CESC cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg03060546 chr3:49711283 APEH 0.51 6.07 0.35 4.29e-9 Parkinson's disease; CESC cis rs4588572 0.644 rs1428864 chr5:77780263 C/T cg11547950 chr5:77652471 NA -0.37 -5.23 -0.31 3.52e-7 Triglycerides; CESC cis rs12291225 0.546 rs11023199 chr11:14394258 A/G cg19336497 chr11:14380999 RRAS2 -0.43 -6.29 -0.36 1.28e-9 Sense of smell; CESC cis rs17666538 0.642 rs7821983 chr8:643696 A/G cg23958373 chr8:599963 NA 0.77 6.5 0.37 3.86e-10 IgG glycosylation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11687679 chr13:37573611 EXOSC8;ALG5 -0.42 -6.45 -0.37 5.37e-10 Gambling; CESC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.69 0.38 1.34e-10 Bipolar disorder; CESC cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg03467027 chr4:99064603 C4orf37 0.43 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2635047 0.967 rs2571016 chr18:44639175 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.55 -7.67 -0.43 3.35e-13 Educational attainment; CESC cis rs6032067 0.632 rs35632684 chr20:43802889 C/T cg10761708 chr20:43804764 PI3 0.56 6.65 0.38 1.7e-10 Blood protein levels; CESC cis rs2072732 0.644 rs75787210 chr1:2942465 A/G cg15211996 chr1:2936768 ACTRT2 0.34 5.63 0.33 4.63e-8 Plateletcrit; CESC cis rs1472360 0.505 rs2645049 chr8:86272555 A/G cg21346043 chr8:86351067 CA3 -0.38 -5.25 -0.31 3.15e-7 Mean corpuscular hemoglobin concentration; CESC cis rs2710642 0.611 rs1534419 chr2:62883936 C/A cg17519650 chr2:63277830 OTX1 0.45 5.3 0.31 2.47e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs6088580 0.634 rs6087580 chr20:32992592 A/G cg08999081 chr20:33150536 PIGU -0.67 -11.93 -0.59 1.56e-26 Glomerular filtration rate (creatinine); CESC cis rs7580658 0.864 rs10928761 chr2:128003247 C/T cg10021288 chr2:128175891 PROC -0.37 -5.91 -0.34 1.07e-8 Protein C levels; CESC cis rs4971059 0.654 rs4971052 chr1:155126018 C/T cg22049894 chr1:155113146 DPM3 0.47 6.07 0.35 4.4e-9 Breast cancer; CESC cis rs6500602 0.893 rs4785962 chr16:4484328 A/G cg08645402 chr16:4508243 NA 0.42 6.2 0.36 2.13e-9 Schizophrenia; CESC cis rs858239 0.539 rs6956828 chr7:23187347 A/G cg23682824 chr7:23144976 KLHL7 0.5 6.58 0.37 2.5e-10 Cerebrospinal fluid biomarker levels; CESC cis rs11252926 0.770 rs2124585 chr10:680428 G/A cg16386425 chr10:429943 DIP2C -0.47 -5.89 -0.34 1.16e-8 Psychosis in Alzheimer's disease; CESC trans rs1814175 0.935 rs7925863 chr11:49615802 C/A cg03929089 chr4:120376271 NA -0.88 -13.25 -0.63 4.46e-31 Height; CESC cis rs1552244 0.554 rs13079240 chr3:10047246 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 7.99 0.44 4.24e-14 Alzheimer's disease; CESC cis rs950776 0.518 rs11632604 chr15:78821914 T/C cg24631222 chr15:78858424 CHRNA5 -0.42 -5.33 -0.31 2.09e-7 Sudden cardiac arrest; CESC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg11764359 chr7:65958608 NA 0.66 8.56 0.47 9.38e-16 Aortic root size; CESC cis rs41563 0.609 rs4727614 chr7:104600854 C/A cg04380332 chr7:105027541 SRPK2 -0.38 -5.46 -0.32 1.09e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7408868 1.000 rs8107180 chr19:15275430 T/C cg14696996 chr19:15285081 NOTCH3 1.11 11.47 0.58 5.57e-25 Pulse pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21157234 chr9:101984918 ALG2;SEC61B 0.59 6.83 0.39 5.8200000000000003e-11 Gut microbiome composition (summer); CESC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.06 -0.3 7.91e-7 Glomerular filtration rate (creatinine); CESC cis rs1018836 0.851 rs7004287 chr8:91620842 G/C cg16814680 chr8:91681699 NA -0.77 -11.99 -0.59 9.5e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -8.89 -0.48 9.73e-17 Developmental language disorder (linguistic errors); CESC trans rs9354308 0.966 rs1909533 chr6:66565658 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 7.98 0.44 4.55e-14 Metabolite levels; CESC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg00149659 chr3:10157352 C3orf10 0.71 8.4 0.46 2.72e-15 Alzheimer's disease; CESC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.79e-7 Gut microbiome composition (summer); CESC cis rs79839061 0.610 rs2279181 chr4:882643 A/G cg07828340 chr4:882639 GAK -0.83 -7.05 -0.4 1.51e-11 Intelligence (multi-trait analysis); CESC trans rs4942242 1.000 rs9533566 chr13:44224691 T/C cg19169023 chr15:41853346 TYRO3 -0.45 -6.48 -0.37 4.53e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9926296 0.744 rs154657 chr16:89708096 A/G cg01097406 chr16:89675127 NA -0.37 -5.46 -0.32 1.08e-7 Vitiligo; CESC cis rs6087990 0.731 rs2424897 chr20:31338098 A/T cg13636640 chr20:31349939 DNMT3B 0.84 14.85 0.67 1.07e-36 Ulcerative colitis; CESC cis rs1670533 0.932 rs11731289 chr4:1057773 T/G cg27284194 chr4:1044797 NA 0.48 6.06 0.35 4.7e-9 Recombination rate (females); CESC cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg09640425 chr7:158790006 NA 0.36 5.59 0.32 5.71e-8 Facial morphology (factor 20); CESC cis rs8017423 0.647 rs12883000 chr14:90820557 G/A cg14092571 chr14:90743983 NA 0.43 6.55 0.37 2.93e-10 Mortality in heart failure; CESC cis rs727505 0.909 rs7810427 chr7:124645103 C/T cg23710748 chr7:124431027 NA -0.44 -6.9 -0.39 3.88e-11 Lewy body disease; CESC cis rs3815700 1.000 rs8113165 chr19:33096316 C/T cg24916020 chr19:33096688 ANKRD27 0.61 6.09 0.35 4.01e-9 Eosinophilic esophagitis; CESC cis rs2070488 1.000 rs1002676 chr3:38444932 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.91 -16.26 -0.71 1.05e-41 Electrocardiographic conduction measures; CESC cis rs7937682 0.924 rs6589244 chr11:111534333 T/C cg22437258 chr11:111473054 SIK2 0.7 9.2 0.49 1.1e-17 Primary sclerosing cholangitis; CESC cis rs17376456 0.877 rs35747258 chr5:93310129 C/T cg25358565 chr5:93447407 FAM172A 1.07 10.61 0.55 3.7e-22 Diabetic retinopathy; CESC cis rs73071352 0.577 rs73075228 chr3:42049629 T/G cg03022575 chr3:42003672 ULK4 0.76 6.66 0.38 1.53e-10 Multiple myeloma and monoclonal gammopathy;Multiple myeloma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10831391 chr10:3109765 PFKP 0.55 6.64 0.38 1.77e-10 Gut microbiome composition (summer); CESC cis rs1580019 0.961 rs766660 chr7:32499077 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.1 0.53 1.62e-20 Cognitive ability; CESC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg19774624 chr17:42201019 HDAC5 0.61 8.74 0.47 2.81e-16 Total body bone mineral density; CESC cis rs9341808 0.667 rs2490239 chr6:80826289 G/A cg08355045 chr6:80787529 NA 0.34 5.28 0.31 2.7e-7 Sitting height ratio; CESC cis rs12410462 0.901 rs16847844 chr1:227638110 A/G cg23173402 chr1:227635558 NA 0.58 5.88 0.34 1.24e-8 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02183680 chr14:75530768 ACYP1 -0.59 -6.98 -0.39 2.43e-11 Gut microbiome composition (summer); CESC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg22590775 chr19:49891494 CCDC155 0.58 6.74 0.38 9.91e-11 Multiple sclerosis; CESC cis rs7208859 0.623 rs80355557 chr17:29154421 C/T cg13385521 chr17:29058706 SUZ12P 0.75 5.95 0.34 8.3e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1003719 0.788 rs1543749 chr21:38446621 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.7 0.47 3.48e-16 Eye color traits; CESC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg18765753 chr7:1198926 ZFAND2A -0.54 -8.2 -0.45 1.06e-14 Longevity;Endometriosis; CESC cis rs4595586 0.546 rs11169801 chr12:39241429 G/A cg26384229 chr12:38710491 ALG10B 0.68 10.2 0.53 7.99e-21 Morning vs. evening chronotype; CESC cis rs3733585 0.673 rs6849729 chr4:9958732 T/C cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7851660 0.967 rs1867280 chr9:100616066 G/C cg13688889 chr9:100608707 NA -0.69 -10.57 -0.54 4.92e-22 Strep throat; CESC cis rs1401999 0.690 rs3805112 chr3:183645662 C/T cg01324343 chr3:183735012 ABCC5 0.48 9.22 0.49 9.33e-18 Anterior chamber depth; CESC cis rs4654899 1.000 rs7550267 chr1:21448792 T/C cg05370193 chr1:21551575 ECE1 0.42 6.34 0.36 9.68e-10 Superior frontal gyrus grey matter volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09287717 chr20:45035259 ELMO2 -0.41 -5.99 -0.35 6.66e-9 Gambling; CESC cis rs13191362 1.000 rs13212608 chr6:163032128 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.81 8.44 0.46 2.13e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg06420487 chr17:61919686 SMARCD2 -0.43 -5.22 -0.31 3.61e-7 Height; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg23197559 chr2:232573080 PTMA 0.47 6.36 0.36 9e-10 Thyroid stimulating hormone; CESC cis rs8177179 0.565 rs4355280 chr3:133468425 A/G cg18769074 chr3:133464867 TF 0.29 5.27 0.31 2.89e-7 Iron status biomarkers (transferrin levels); CESC cis rs2282802 0.685 rs10077671 chr5:139689505 C/T cg26211634 chr5:139558579 C5orf32 0.47 6.7 0.38 1.28e-10 Intelligence (multi-trait analysis); CESC cis rs4481887 1.000 rs10888358 chr1:248471467 C/A cg00666640 chr1:248458726 OR2T12 0.4 6.57 0.37 2.7e-10 Common traits (Other); CESC cis rs17001868 0.568 rs9611316 chr22:40737027 A/G cg07138101 chr22:40742427 ADSL 0.57 5.38 0.31 1.66e-7 Mammographic density (dense area); CESC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg22535103 chr8:58192502 C8orf71 -0.49 -6.34 -0.36 9.76e-10 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC trans rs7726839 0.526 rs11960159 chr5:568685 C/T cg25482853 chr8:67687455 SGK3 0.97 10.92 0.56 3.67e-23 Obesity-related traits; CESC cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.34 -5.78 -0.33 2.13e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.24 -0.31 3.21e-7 Total body bone mineral density; CESC cis rs9325144 0.723 rs11169519 chr12:39177441 G/A cg26384229 chr12:38710491 ALG10B -0.51 -7.36 -0.41 2.26e-12 Morning vs. evening chronotype; CESC cis rs238295 0.805 rs6085211 chr20:5552847 G/C cg24001556 chr20:5591874 RP5-1022P6.2 -0.46 -5.11 -0.3 6.12e-7 Occipital cortical area (total cortical area interaction); CESC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg04518342 chr5:131593106 PDLIM4 0.37 5.24 0.31 3.31e-7 Breast cancer; CESC cis rs5769765 1.000 rs764813 chr22:50286172 T/C cg02269571 chr22:50332266 NA -0.46 -6.26 -0.36 1.53e-9 Schizophrenia; CESC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.7 9.25 0.49 7.84e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg19774624 chr17:42201019 HDAC5 -0.9 -14.62 -0.67 6.95e-36 Total body bone mineral density; CESC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg17724175 chr1:150552817 MCL1 0.38 5.9 0.34 1.13e-8 Melanoma; CESC cis rs9457247 1.000 rs2757047 chr6:167374489 C/T cg25258033 chr6:167368657 RNASET2 -0.42 -6.29 -0.36 1.31e-9 Crohn's disease; CESC cis rs7917772 0.565 rs1043450 chr10:104434209 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.59 7.25 0.41 4.63e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17042849 chr6:26104293 HIST1H4C 0.55 6.52 0.37 3.61e-10 Gut microbiome composition (summer); CESC cis rs7129220 0.858 rs61878630 chr11:10132815 A/T cg01453529 chr11:10209919 SBF2 -0.48 -5.54 -0.32 7.12e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24830314 chr6:83775579 UBE2CBP 0.61 7.5 0.42 9.66e-13 Gut microbiome composition (summer); CESC cis rs6088580 0.524 rs6087612 chr20:33230822 T/G cg24642439 chr20:33292090 TP53INP2 -0.45 -5.26 -0.31 2.96e-7 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24720361 chr12:57882021 MARS -0.57 -6.65 -0.38 1.68e-10 Gut microbiome composition (summer); CESC cis rs919433 0.783 rs2565158 chr2:198236103 T/A cg20885578 chr2:198174922 NA 0.41 5.38 0.31 1.62e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg00684032 chr4:1343700 KIAA1530 0.41 5.84 0.34 1.49e-8 Obesity-related traits; CESC cis rs2718058 0.519 rs2722242 chr7:37873610 A/G cg15028436 chr7:37888078 TXNDC3 -0.46 -6.94 -0.39 2.94e-11 Alzheimer's disease (late onset); CESC cis rs9322193 0.923 rs12175504 chr6:149985215 T/G cg13206674 chr6:150067644 NUP43 0.4 5.52 0.32 8.03e-8 Lung cancer; CESC cis rs2073300 1.000 rs6132628 chr20:23446734 G/A cg12062639 chr20:23401060 NAPB 1.02 7.12 0.4 1.04e-11 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9549260 1.000 rs9549260 chr13:41254104 G/T cg21288729 chr13:41239152 FOXO1 0.55 6.26 0.36 1.54e-9 Red blood cell count; CESC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg10896456 chr17:42255109 ASB16;C17orf65 0.49 7.37 0.41 2.19e-12 Total body bone mineral density; CESC cis rs12618769 0.597 rs72821946 chr2:99142411 G/C cg10123293 chr2:99228465 UNC50 0.41 5.44 0.32 1.24e-7 Bipolar disorder; CESC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg18446336 chr7:2847575 GNA12 -0.34 -5.16 -0.3 4.83e-7 Height; CESC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg14393609 chr7:65229607 NA 0.5 6.67 0.38 1.52e-10 Aortic root size; CESC cis rs3126085 0.935 rs10888475 chr1:152226012 C/T cg03465714 chr1:152285911 FLG -0.43 -5.5 -0.32 9.02e-8 Atopic dermatitis; CESC trans rs7615952 0.599 rs6438953 chr3:125724951 T/C cg07211511 chr3:129823064 LOC729375 -0.59 -7.29 -0.41 3.66e-12 Blood pressure (smoking interaction); CESC cis rs36051895 0.530 rs4425810 chr9:5222208 A/G cg02405213 chr9:5042618 JAK2 -0.52 -6.3 -0.36 1.26e-9 Pediatric autoimmune diseases; CESC cis rs2276314 1.000 rs1789513 chr18:33545630 A/G cg05985134 chr18:33552581 C18orf21 -0.67 -7.94 -0.44 5.61e-14 Endometriosis;Drug-induced torsades de pointes; CESC cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg00684032 chr4:1343700 KIAA1530 0.5 6.87 0.39 4.52e-11 Obesity-related traits; CESC cis rs6460942 1.000 rs2033871 chr7:12405098 C/A cg06484146 chr7:12443880 VWDE -0.7 -8.15 -0.45 1.5e-14 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19230709 chr19:4933046 UHRF1 0.49 6.41 0.37 6.81e-10 Fibrinogen levels; CESC cis rs4595586 0.525 rs12818844 chr12:39423806 A/G cg13010199 chr12:38710504 ALG10B 0.44 5.42 0.32 1.31e-7 Morning vs. evening chronotype; CESC cis rs7927771 1.000 rs10838747 chr11:47716324 G/C cg05585544 chr11:47624801 NA -0.5 -7.9 -0.44 7.51e-14 Subjective well-being; CESC cis rs4908768 0.539 rs1809332 chr1:8656434 C/T cg00120948 chr1:8484417 RERE -0.32 -5.03 -0.3 9.13e-7 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CESC cis rs1729951 0.575 rs1654904 chr3:136681149 T/C cg04103450 chr3:136751342 NA 0.4 5.28 0.31 2.67e-7 Neuroticism; CESC cis rs933688 1.000 rs2052553 chr5:90729906 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.17 16.18 0.7 2e-41 Smoking behavior; CESC cis rs7927592 0.913 rs10896346 chr11:68352671 C/T cg20283391 chr11:68216788 NA -0.61 -7.29 -0.41 3.48e-12 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18442181 chr17:29233375 C17orf42 0.59 6.93 0.39 3.23e-11 Gut microbiome composition (summer); CESC cis rs854765 0.583 rs8075965 chr17:17853180 A/T cg09796270 chr17:17721594 SREBF1 0.44 6.05 0.35 4.92e-9 Total body bone mineral density; CESC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg22903657 chr4:1355424 KIAA1530 -0.37 -5.1 -0.3 6.6e-7 Obesity-related traits; CESC cis rs55871839 0.619 rs6471756 chr8:59802159 A/G cg07426533 chr8:59803705 TOX -0.5 -7.23 -0.41 5.26e-12 Pneumonia; CESC cis rs4764487 0.735 rs2072370 chr12:6345080 A/G cg08284733 chr12:6341482 CD9 -0.41 -6.22 -0.36 1.97e-9 Mean platelet volume; CESC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg04772025 chr11:68637568 NA 0.51 6.38 0.36 7.84e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10170846 0.789 rs972650 chr2:223520287 C/T cg25565276 chr2:223520875 FARSB 0.5 6.97 0.39 2.5e-11 Schizophrenia (inflammation and infection response interaction); CESC cis rs34779708 0.931 rs7099036 chr10:35349574 C/T cg03585969 chr10:35415529 CREM 0.76 10.04 0.52 2.64e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.72 -9.34 -0.5 3.96e-18 Alzheimer's disease; CESC trans rs10510829 1.000 rs11715209 chr3:60123590 A/G cg02594498 chr15:22893147 CYFIP1 0.56 6.02 0.35 5.83e-9 Adverse response to lamotrigine and phenytoin; CESC cis rs12477438 0.765 rs7591794 chr2:99567514 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -9.4 -0.5 2.65e-18 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26593967 chr16:89926151 SPIRE2 -0.48 -6.07 -0.35 4.48e-9 Gut microbiome composition (summer); CESC cis rs2952156 0.883 rs907089 chr17:37833600 C/T cg00129232 chr17:37814104 STARD3 -0.72 -10.14 -0.53 1.25e-20 Asthma; CESC cis rs3733585 0.673 rs4292333 chr4:9953871 G/A cg11266682 chr4:10021025 SLC2A9 -0.58 -11.0 -0.56 2.04e-23 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03993171 chr6:86388501 SNORD50B;SNORD50A;SNHG5 0.55 6.51 0.37 3.66e-10 Gut microbiome composition (summer); CESC cis rs763121 0.853 rs2072798 chr22:39148483 G/A cg06544989 chr22:39130855 UNC84B 0.5 8.92 0.48 7.59e-17 Menopause (age at onset); CESC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg00166722 chr3:10149974 C3orf24 0.48 6.18 0.36 2.38e-9 Alzheimer's disease; CESC cis rs4642101 0.662 rs1969154 chr3:12829156 A/G cg24848339 chr3:12840334 CAND2 0.36 5.47 0.32 1.06e-7 QRS complex (12-leadsum); CESC cis rs9660992 0.573 rs12144980 chr1:205185104 C/T cg21643547 chr1:205240462 TMCC2 -0.39 -5.5 -0.32 8.97e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs9858542 0.953 rs9841110 chr3:49492481 C/G cg07274523 chr3:49395745 GPX1 0.65 7.92 0.44 6.77e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs116095464 0.558 rs9312956 chr5:201812 T/C cg22496380 chr5:211416 CCDC127 -0.95 -10.44 -0.54 1.37e-21 Breast cancer; CESC cis rs72945132 0.882 rs3900797 chr11:70186614 C/T cg14191688 chr11:70257035 CTTN 0.44 5.62 0.33 4.82e-8 Coronary artery disease; CESC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg11764359 chr7:65958608 NA -0.73 -9.8 -0.52 1.49e-19 Aortic root size; CESC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg02931644 chr1:25747376 RHCE -0.47 -8.21 -0.45 9.84e-15 Plateletcrit;Mean corpuscular volume; CESC cis rs10465746 0.780 rs2389648 chr1:84403031 C/T cg10977910 chr1:84465055 TTLL7 0.53 7.18 0.4 7.19e-12 Obesity-related traits; CESC cis rs614226 0.935 rs3887875 chr12:120895749 A/G cg01236616 chr12:121019343 POP5 -1.39 -15.84 -0.7 3.24e-40 Type 1 diabetes nephropathy; CESC trans rs7741085 0.967 rs11752730 chr6:44639100 C/G cg04735960 chr13:21006388 CRYL1 0.44 6.08 0.35 4.09e-9 Total body bone mineral density; CESC cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.79 8.31 0.45 5.17e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7208859 0.623 rs28433704 chr17:29084285 G/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg01341218 chr17:43662625 NA 0.55 7.39 0.41 1.86e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2242116 0.796 rs7645278 chr3:46974100 A/C cg02527881 chr3:46936655 PTH1R -0.51 -7.38 -0.41 2.01e-12 Birth weight; CESC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg07677032 chr17:61819896 STRADA 0.41 5.17 0.3 4.59e-7 Height; CESC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs72945132 0.882 rs17160762 chr11:70134766 A/G cg14191688 chr11:70257035 CTTN -0.42 -5.24 -0.31 3.35e-7 Coronary artery disease; CESC cis rs12900413 0.603 rs2882678 chr15:90299542 A/G cg24249390 chr15:90295951 MESP1 -0.4 -5.42 -0.32 1.33e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs7223966 1.000 rs2013288 chr17:61785904 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.04 0.4 1.61e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg18180107 chr4:99064573 C4orf37 0.39 5.05 0.3 8.17e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg07701084 chr6:150067640 NUP43 0.45 6.26 0.36 1.55e-9 Lung cancer; CESC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg18032046 chr6:28092343 ZSCAN16 -0.6 -6.82 -0.39 6.29e-11 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19136717 chr15:72766740 ARIH1 0.66 7.65 0.43 3.62e-13 Gut microbiome composition (summer); CESC cis rs116095464 0.558 rs57335027 chr5:262907 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.49 0.32 9.44e-8 Breast cancer; CESC cis rs4076764 0.801 rs12046142 chr1:163375247 G/A cg24596788 chr1:163392923 NA -0.42 -5.99 -0.35 6.85e-9 Motion sickness; CESC cis rs10754283 0.935 rs1934046 chr1:90119290 A/T cg21401794 chr1:90099060 LRRC8C -0.66 -8.7 -0.47 3.61e-16 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg21782813 chr7:2030301 MAD1L1 0.42 5.98 0.35 7e-9 Bipolar disorder and schizophrenia; CESC cis rs7131987 0.845 rs2042511 chr12:29408780 C/T cg09582351 chr12:29534625 ERGIC2 -0.35 -5.59 -0.32 5.57e-8 QT interval; CESC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.16 0.35 2.66e-9 Personality dimensions; CESC cis rs727505 0.521 rs66787780 chr7:124791849 G/A cg23710748 chr7:124431027 NA -0.4 -6.2 -0.36 2.11e-9 Lewy body disease; CESC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg03396347 chr1:1875803 NA -0.44 -6.96 -0.39 2.68e-11 Body mass index; CESC cis rs17854409 0.536 rs3765464 chr20:61485236 T/C cg05147244 chr20:61493195 TCFL5 1.0 7.42 0.41 1.64e-12 Obesity-related traits; CESC cis rs8018808 1.000 rs11844594 chr14:77843814 T/C cg20045696 chr14:77926864 AHSA1 -0.38 -5.18 -0.3 4.32e-7 Myeloid white cell count; CESC cis rs7605827 0.538 rs62120660 chr2:15659613 T/C cg19274914 chr2:15703543 NA 0.36 6.31 0.36 1.18e-9 Educational attainment (years of education); CESC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg06808227 chr14:105710500 BRF1 -0.61 -7.43 -0.42 1.48e-12 Mean platelet volume;Platelet distribution width; CESC cis rs1538970 0.739 rs4660863 chr1:45955868 T/C cg03146154 chr1:46216737 IPP 0.49 5.57 0.32 6.31e-8 Platelet count; CESC cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg02018176 chr4:1364513 KIAA1530 0.41 5.04 0.3 8.73e-7 Obesity-related traits; CESC cis rs35955747 0.714 rs4820048 chr22:31854370 A/G cg25791279 chr22:32026902 PISD -0.44 -5.22 -0.31 3.56e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs6502050 0.740 rs4789748 chr17:80093061 A/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.16 -0.3 4.92e-7 Life satisfaction; CESC cis rs7917772 0.545 rs10786681 chr10:104317357 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.69 0.33 3.27e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6754311 0.773 rs309125 chr2:136643555 C/T cg07169764 chr2:136633963 MCM6 0.68 8.53 0.46 1.14e-15 Mosquito bite size; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg23393291 chr15:101142359 ASB7;LINS1 -0.45 -6.01 -0.35 6.16e-9 Height; CESC cis rs1152591 0.811 rs1255986 chr14:64655161 A/G cg23250157 chr14:64679961 SYNE2 -0.52 -7.58 -0.42 6.01e-13 Atrial fibrillation; CESC cis rs1707322 1.000 rs785486 chr1:46575148 G/C cg06784218 chr1:46089804 CCDC17 -0.33 -5.63 -0.33 4.67e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2354432 0.607 rs11579626 chr1:146741960 A/C cg25205988 chr1:146714368 CHD1L -0.9 -7.78 -0.43 1.64e-13 Mitochondrial DNA levels; CESC trans rs7937840 0.562 rs1047739 chr11:61919693 C/T cg10934129 chr5:172655841 NA -0.45 -6.41 -0.37 6.71e-10 Breast cancer; CESC cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg11644478 chr21:40555479 PSMG1 0.79 8.31 0.45 4.88e-15 Cognitive function; CESC cis rs4253772 0.591 rs6008361 chr22:46652372 A/G cg10231785 chr22:46692440 CN5H6.4;GTSE1 -0.48 -5.1 -0.3 6.43e-7 LDL cholesterol;Cholesterol, total; CESC cis rs4901847 0.609 rs11158198 chr14:58576320 G/T cg15908186 chr14:58618357 C14orf37 -0.36 -5.55 -0.32 7.1e-8 Lupus nephritis in systemic lupus erythematosus; CESC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.19 0.4 6.57e-12 Depression; CESC cis rs2760061 0.598 rs658238 chr1:228121291 A/G cg02753203 chr1:228287806 NA -0.51 -7.36 -0.41 2.26e-12 Diastolic blood pressure; CESC cis rs10256972 0.527 rs2949170 chr7:1216438 A/G cg16145915 chr7:1198662 ZFAND2A -0.67 -10.01 -0.52 3.22e-20 Longevity;Endometriosis; CESC cis rs793571 0.744 rs12901551 chr15:59160069 A/T cg05156742 chr15:59063176 FAM63B -0.47 -6.15 -0.35 2.78e-9 Schizophrenia; CESC cis rs832540 0.656 rs702689 chr5:56177443 G/A cg12311346 chr5:56204834 C5orf35 -0.42 -5.14 -0.3 5.32e-7 Coronary artery disease; CESC cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.79 7.79 0.43 1.52e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2072732 0.861 rs10909865 chr1:2956163 A/G cg03976712 chr1:2946727 NA 0.33 5.53 0.32 7.83e-8 Plateletcrit; CESC trans rs1005277 0.579 rs1614236 chr10:38502996 C/T cg27523141 chr10:43048294 ZNF37B 0.46 6.02 0.35 5.91e-9 Extrinsic epigenetic age acceleration; CESC cis rs7937682 0.961 rs7106104 chr11:111635655 T/C cg22437258 chr11:111473054 SIK2 -0.59 -6.54 -0.37 3.21e-10 Primary sclerosing cholangitis; CESC cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11864453 0.786 rs1050362 chr16:72130815 C/A cg16558253 chr16:72132732 DHX38 -0.61 -9.61 -0.51 6.02e-19 Fibrinogen levels; CESC cis rs1775715 0.707 rs2065443 chr10:32164236 C/G cg18675610 chr10:32216311 ARHGAP12 0.34 5.29 0.31 2.55e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg10645314 chr2:3704589 ALLC -0.46 -5.18 -0.3 4.35e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg09359103 chr1:154839909 KCNN3 -0.68 -13.02 -0.62 2.79e-30 Prostate cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22122361 chr4:79697742 BMP2K -0.49 -6.1 -0.35 3.71e-9 Ulcerative colitis; CESC cis rs16854884 0.657 rs35959290 chr3:143725566 T/A cg06585982 chr3:143692056 C3orf58 0.47 5.77 0.33 2.18e-8 Economic and political preferences (feminism/equality); CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg22907277 chr7:1156413 C7orf50 0.47 5.43 0.32 1.27e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9815354 0.812 rs73073323 chr3:41834051 C/T cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs3092073 0.603 rs4810477 chr20:44544654 C/T cg00125455 chr20:44574271 PCIF1 0.37 5.67 0.33 3.64e-8 Intelligence (multi-trait analysis); CESC cis rs10465746 0.967 rs6670658 chr1:84461268 A/G cg10977910 chr1:84465055 TTLL7 0.47 6.41 0.37 6.56e-10 Obesity-related traits; CESC cis rs7980687 0.657 rs10744151 chr12:123723735 G/C cg00376283 chr12:123451042 ABCB9 0.67 8.93 0.48 7.19e-17 Height;Educational attainment;Head circumference (infant); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19567168 chr12:6438502 TNFRSF1A 0.51 6.9 0.39 3.76e-11 Fibrinogen levels; CESC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg07701084 chr6:150067640 NUP43 0.41 5.57 0.32 6.38e-8 Lung cancer; CESC cis rs6752107 0.936 rs6431660 chr2:234167234 A/G cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.4 6.07 0.35 4.35e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs7267979 0.706 rs6138542 chr20:25207773 C/A cg08601574 chr20:25228251 PYGB 0.43 6.01 0.35 6.19e-9 Liver enzyme levels (alkaline phosphatase); CESC cis rs9902453 0.740 rs2617867 chr17:28049399 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.76 -10.15 -0.53 1.14e-20 Coffee consumption (cups per day); CESC cis rs9905704 0.918 rs302862 chr17:56697444 G/T cg12560992 chr17:57184187 TRIM37 0.59 7.02 0.4 1.86e-11 Testicular germ cell tumor; CESC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -7.04 -0.4 1.69e-11 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13559099 chr11:62554740 TMEM179B;TAF6L 0.59 7.03 0.4 1.8e-11 Gut microbiome composition (summer); CESC cis rs7258465 1.000 rs8107367 chr19:18564705 A/G cg25828334 chr19:18545568 ISYNA1 -0.32 -5.1 -0.3 6.57e-7 Breast cancer; CESC cis rs35740288 0.580 rs34526042 chr15:86339956 C/T cg20737812 chr15:86336631 KLHL25 -0.42 -5.31 -0.31 2.28e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs11690935 0.802 rs34636594 chr2:172911094 A/G cg13550731 chr2:172543902 DYNC1I2 -0.86 -11.03 -0.56 1.54e-23 Schizophrenia; CESC cis rs453301 0.571 rs330048 chr8:9087278 A/C cg17143192 chr8:8559678 CLDN23 -0.45 -5.41 -0.32 1.38e-7 Joint mobility (Beighton score); CESC cis rs3820928 0.967 rs4675118 chr2:227773157 C/A cg05526886 chr2:227700861 RHBDD1 -0.38 -5.03 -0.3 9.03e-7 Pulmonary function; CESC cis rs9811920 0.609 rs4244711 chr3:99657205 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.6 -7.27 -0.41 4.12e-12 Axial length; CESC cis rs2415984 0.622 rs28487986 chr14:46924435 T/G cg14871534 chr14:47121158 RPL10L -0.35 -5.28 -0.31 2.64e-7 Number of children ever born; CESC cis rs10883723 0.810 rs2296586 chr10:104245575 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.75 -0.33 2.44e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7772486 0.790 rs1133832 chr6:146205604 C/T cg23711669 chr6:146136114 FBXO30 -0.8 -11.78 -0.59 4.95e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs7208859 0.573 rs73267872 chr17:29067207 T/C cg19761014 chr17:28927070 LRRC37B2 0.78 6.46 0.37 5.11e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2070997 0.607 rs10901283 chr9:133663242 G/A cg11464064 chr9:133710261 ABL1 0.54 6.16 0.35 2.65e-9 Response to amphetamines; CESC cis rs910316 1.000 rs175443 chr14:75601963 C/T cg11812906 chr14:75593930 NEK9 -0.87 -14.66 -0.67 4.88e-36 Height; CESC trans rs4904167 0.841 rs7148526 chr14:84688008 C/T cg06870609 chr15:89787223 FANCI 0.46 6.06 0.35 4.6e-9 Autism spectrum disorder or schizophrenia; CESC cis rs1401999 0.546 rs4148593 chr3:183649870 A/G cg01324343 chr3:183735012 ABCC5 0.37 6.38 0.36 7.82e-10 Anterior chamber depth; CESC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.52 -0.37 3.57e-10 Bipolar disorder; CESC cis rs4819052 0.959 rs9976074 chr21:46655638 G/T cg11663144 chr21:46675770 NA -0.48 -6.37 -0.36 8.26e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg04329845 chr19:14640100 MIR639;TECR 0.48 6.57 0.37 2.7e-10 Bronchopulmonary dysplasia; CESC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg24642844 chr7:1081250 C7orf50 -0.76 -9.45 -0.5 1.94e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs611744 0.625 rs6469168 chr8:109288399 G/T cg21045802 chr8:109455806 TTC35 0.55 6.84 0.39 5.44e-11 Dupuytren's disease; CESC cis rs3617 0.625 rs11719137 chr3:52876389 G/T cg07507251 chr3:52567010 NT5DC2 -0.32 -5.44 -0.32 1.22e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs67478160 0.643 rs2295145 chr14:104202304 G/A cg08213375 chr14:104286397 PPP1R13B 0.52 10.26 0.53 5.03e-21 Schizophrenia; CESC cis rs9549260 0.534 rs4943810 chr13:41297405 C/A cg21288729 chr13:41239152 FOXO1 0.57 5.15 0.3 5.1e-7 Red blood cell count; CESC cis rs5769765 0.862 rs9616774 chr22:50290599 G/A cg02269571 chr22:50332266 NA -0.45 -6.07 -0.35 4.4e-9 Schizophrenia; CESC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg11764359 chr7:65958608 NA 0.67 8.84 0.48 1.32e-16 Aortic root size; CESC cis rs9322193 0.884 rs9397036 chr6:150172923 C/T cg13206674 chr6:150067644 NUP43 0.38 5.12 0.3 5.81e-7 Lung cancer; CESC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.31 -5.07 -0.3 7.45e-7 Bipolar disorder; CESC cis rs929354 0.742 rs7807556 chr7:156934329 T/C cg05182265 chr7:156933206 UBE3C -0.48 -7.02 -0.4 1.86e-11 Body mass index; CESC cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg26597838 chr10:835615 NA 0.78 9.15 0.49 1.6e-17 Eosinophil percentage of granulocytes; CESC cis rs13385 0.769 rs35543394 chr5:139592844 T/A cg26211634 chr5:139558579 C5orf32 0.46 5.2 0.3 3.99e-7 Atrial fibrillation; CESC cis rs6061231 0.631 rs2427318 chr20:60975727 G/T cg15674680 chr20:60982522 CABLES2 0.42 5.35 0.31 1.89e-7 Colorectal cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19263974 chr12:3103878 TEAD4 0.44 6.09 0.35 3.86e-9 Fibrinogen levels; CESC cis rs909674 0.690 rs5750825 chr22:39831278 A/G cg05872129 chr22:39784769 NA -0.78 -10.46 -0.54 1.13e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs698833 0.537 rs698826 chr2:44728418 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.35 0.31 1.92e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg18758796 chr5:131593413 PDLIM4 -0.43 -5.96 -0.34 8.15e-9 Breast cancer; CESC cis rs10876993 0.806 rs1689598 chr12:58050500 G/C cg18357645 chr12:58087776 OS9 0.6 9.23 0.49 8.88e-18 Celiac disease or Rheumatoid arthritis; CESC trans rs6818288 0.778 rs12503609 chr4:30077578 G/A cg12528397 chr3:62933670 NA 0.42 6.13 0.35 3.2e-9 Obesity-related traits; CESC cis rs7656342 0.636 rs1914874 chr4:9839490 C/A cg00071950 chr4:10020882 SLC2A9 -0.42 -5.53 -0.32 7.74e-8 Gut microbiota (bacterial taxa); CESC cis rs3617 0.625 rs2535633 chr3:52859630 C/G cg07507251 chr3:52567010 NT5DC2 -0.34 -6.0 -0.35 6.47e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg25019033 chr10:957182 NA 0.58 6.71 0.38 1.2e-10 Eosinophil percentage of granulocytes; CESC cis rs4474465 0.688 rs4944210 chr11:78282878 C/T cg27205649 chr11:78285834 NARS2 0.49 6.38 0.37 7.72e-10 Alzheimer's disease (survival time); CESC cis rs12348691 0.503 rs7024345 chr9:100595238 A/G cg13688889 chr9:100608707 NA -0.9 -13.3 -0.63 3.01e-31 Alopecia areata; CESC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg04414720 chr1:150670196 GOLPH3L 0.61 8.65 0.47 5.17e-16 Melanoma; CESC cis rs9291683 0.507 rs6845554 chr4:10013173 T/G cg00071950 chr4:10020882 SLC2A9 0.82 13.81 0.65 4.68e-33 Bone mineral density; CESC cis rs6460942 0.597 rs6961238 chr7:12535428 C/T cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs7178909 0.902 rs8038480 chr15:90441597 T/C cg19708238 chr15:90437601 AP3S2 0.45 6.41 0.37 6.78e-10 Common traits (Other); CESC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg19052272 chr2:3704530 ALLC -0.79 -9.52 -0.5 1.1e-18 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs12701220 0.522 rs12334290 chr7:1054517 A/G cg23978390 chr7:1156363 C7orf50 0.42 5.21 0.31 3.74e-7 Bronchopulmonary dysplasia; CESC cis rs11252926 0.673 rs7096559 chr10:499188 C/T cg03684893 chr10:554711 DIP2C -0.42 -6.39 -0.37 7.59e-10 Psychosis in Alzheimer's disease; CESC cis rs6121246 0.909 rs6060679 chr20:30270772 C/G cg13852791 chr20:30311386 BCL2L1 -0.75 -7.94 -0.44 5.91e-14 Mean corpuscular hemoglobin; CESC cis rs4604732 0.642 rs4266925 chr1:247639165 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.46 0.32 1.1e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1728785 0.818 rs1170430 chr16:68604954 T/C cg02972257 chr16:68554789 NA -0.59 -6.71 -0.38 1.2e-10 Ulcerative colitis; CESC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.87 14.29 0.66 1e-34 Menarche (age at onset); CESC cis rs228769 0.562 rs228762 chr17:42138392 C/T cg19774624 chr17:42201019 HDAC5 0.54 6.28 0.36 1.38e-9 Bone mineral density (hip);Bone mineral density (spine); CESC cis rs6499255 0.951 rs10454066 chr16:69699005 A/T cg15192750 chr16:69999425 NA 0.51 5.87 0.34 1.29e-8 IgE levels; CESC cis rs561341 0.882 rs28649357 chr17:30367190 A/G cg13647721 chr17:30228624 UTP6 0.54 5.05 0.3 8.04e-7 Hip circumference adjusted for BMI; CESC cis rs4835937 0.645 rs4836348 chr5:127278773 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.52 5.07 0.3 7.35e-7 Cancer; CESC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg02428538 chr16:24856791 SLC5A11 0.47 5.03 0.3 9.12e-7 Intelligence (multi-trait analysis); CESC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg18876405 chr7:65276391 NA -0.53 -7.19 -0.4 6.72e-12 Aortic root size; CESC cis rs6062302 0.522 rs3787107 chr20:62230576 G/A cg06363034 chr20:62225388 GMEB2 -0.52 -6.66 -0.38 1.6e-10 Glioblastoma; CESC cis rs6752107 1.000 rs13391356 chr2:234170369 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 6.71 0.38 1.21e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs546131 0.928 rs552868 chr11:34830694 G/A cg11058730 chr11:34937778 PDHX;APIP 0.51 6.52 0.37 3.49e-10 Lung disease severity in cystic fibrosis; CESC cis rs7927592 0.913 rs7127948 chr11:68363062 G/A cg20283391 chr11:68216788 NA -0.61 -7.29 -0.41 3.48e-12 Total body bone mineral density; CESC cis rs863345 0.526 rs2051067 chr1:158507398 G/T cg12129480 chr1:158549410 OR10X1 -0.35 -7.03 -0.4 1.73e-11 Pneumococcal bacteremia; CESC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg22442454 chr1:209979470 IRF6 0.45 5.09 0.3 6.76e-7 Cleft lip with or without cleft palate; CESC cis rs10465746 0.780 rs11163866 chr1:84367123 A/G cg10977910 chr1:84465055 TTLL7 0.52 7.06 0.4 1.46e-11 Obesity-related traits; CESC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs6088580 0.524 rs7274854 chr20:33228672 A/C cg08999081 chr20:33150536 PIGU 0.42 5.92 0.34 1.01e-8 Glomerular filtration rate (creatinine); CESC cis rs916888 0.821 rs199525 chr17:44847834 T/G cg17911788 chr17:44343683 NA -0.6 -7.81 -0.43 1.32e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs524023 1.000 rs505802 chr11:64357072 T/C cg07220939 chr11:64358617 SLC22A12 0.36 5.54 0.32 7.2e-8 Urate levels in obese individuals; CESC cis rs2904967 0.636 rs239253 chr11:64984743 C/T cg23743554 chr11:65321226 LTBP3 -0.39 -5.14 -0.3 5.38e-7 Mean corpuscular volume; CESC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg04414720 chr1:150670196 GOLPH3L 0.45 5.85 0.34 1.48e-8 Melanoma; CESC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg22535103 chr8:58192502 C8orf71 -0.87 -7.96 -0.44 5.16e-14 Developmental language disorder (linguistic errors); CESC trans rs7937682 0.924 rs1784782 chr11:111525764 A/C cg18187862 chr3:45730750 SACM1L 0.51 6.47 0.37 4.81e-10 Primary sclerosing cholangitis; CESC cis rs6032067 0.929 rs2143944 chr20:43819370 G/A cg10761708 chr20:43804764 PI3 0.53 6.39 0.37 7.37e-10 Blood protein levels; CESC cis rs561341 0.843 rs4795666 chr17:30241409 A/G cg13647721 chr17:30228624 UTP6 0.78 8.91 0.48 8.27e-17 Hip circumference adjusted for BMI; CESC cis rs561341 0.709 rs8068049 chr17:30183857 T/C cg12193833 chr17:30244370 NA 0.6 5.41 0.32 1.42e-7 Hip circumference adjusted for BMI; CESC cis rs7772486 0.632 rs9386128 chr6:146049053 G/A cg23711669 chr6:146136114 FBXO30 -0.87 -12.9 -0.62 7e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs9649465 0.561 rs600420 chr7:123408050 G/A cg03229431 chr7:123269106 ASB15 0.42 5.78 0.33 2.12e-8 Migraine; CESC cis rs6570726 0.935 rs367643 chr6:145859602 A/C cg05347473 chr6:146136440 FBXO30 0.48 6.44 0.37 5.7e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg21770322 chr7:97807741 LMTK2 -0.49 -7.32 -0.41 2.96e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg02725872 chr8:58115012 NA -0.39 -6.8 -0.39 7.05e-11 Developmental language disorder (linguistic errors); CESC cis rs7089973 0.604 rs11196932 chr10:116584386 C/T cg25233709 chr10:116636983 FAM160B1 0.35 5.47 0.32 1.05e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg11108432 chr8:10697698 PINX1 0.48 6.17 0.35 2.58e-9 Tetralogy of Fallot; CESC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg18904891 chr8:8559673 CLDN23 0.69 8.08 0.44 2.26e-14 Obesity-related traits; CESC cis rs6582630 0.519 rs4002440 chr12:38485012 A/G cg26384229 chr12:38710491 ALG10B 0.69 10.39 0.54 1.95e-21 Drug-induced liver injury (flucloxacillin); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg16668921 chr6:107077373 RTN4IP1;QRSL1 -0.52 -6.7 -0.38 1.25e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1215050 0.740 rs783949 chr4:99001933 A/G cg05340658 chr4:99064831 C4orf37 -0.57 -7.58 -0.42 5.78e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2228479 0.850 rs12598316 chr16:89916600 C/A cg04013166 chr16:89971882 TCF25 0.73 5.7 0.33 3.2e-8 Skin colour saturation; CESC cis rs12973672 0.680 rs564117 chr19:35718938 C/T cg12095397 chr19:35769544 USF2 0.43 5.46 0.32 1.12e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs13102973 0.965 rs11735381 chr4:135850474 T/C cg14419869 chr4:135874104 NA 0.33 5.15 0.3 5.11e-7 Subjective well-being; CESC cis rs642803 1.000 rs642803 chr11:65560620 C/T cg02870584 chr11:65547924 DKFZp761E198 0.43 5.45 0.32 1.16e-7 Urate levels; CESC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs793571 0.543 rs11854073 chr15:58972995 G/A cg05156742 chr15:59063176 FAM63B 0.58 7.86 0.43 9.42e-14 Schizophrenia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23604151 chr20:50766090 ZFP64 0.45 6.57 0.37 2.59e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs910316 1.000 rs11159117 chr14:75584867 C/T cg08847533 chr14:75593920 NEK9 1.02 19.72 0.77 6.58e-54 Height; CESC cis rs2742234 0.578 rs2742241 chr10:43625223 G/A cg15436174 chr10:43711423 RASGEF1A -0.47 -5.55 -0.32 6.93e-8 Hirschsprung disease; CESC trans rs3780486 0.718 rs7859454 chr9:33119583 T/A cg20290983 chr6:43655470 MRPS18A 0.67 8.05 0.44 2.83e-14 IgG glycosylation; CESC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg07092213 chr7:1199455 ZFAND2A -0.43 -5.75 -0.33 2.51e-8 Longevity;Endometriosis; CESC cis rs2046867 0.774 rs1393585 chr3:72886722 A/G cg25664220 chr3:72788482 NA -0.46 -6.4 -0.37 7.09e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs11642862 1.000 rs111954099 chr16:30789623 A/G cg02466173 chr16:30829666 NA -0.54 -5.52 -0.32 8.18e-8 Tonsillectomy; CESC cis rs1707322 1.000 rs785498 chr1:46592414 C/T cg06784218 chr1:46089804 CCDC17 -0.35 -5.94 -0.34 8.74e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs9596009 0.591 rs73480227 chr13:49342549 C/T cg13176070 chr2:32503943 YIPF4 0.52 6.08 0.35 4.25e-9 Cough in response to angiotensin-converting enzyme inhibitor drugs; CESC cis rs11098499 0.739 rs4833612 chr4:120147596 A/C cg09307838 chr4:120376055 NA -0.68 -8.42 -0.46 2.43e-15 Corneal astigmatism; CESC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg26338869 chr17:61819248 STRADA 0.71 9.47 0.5 1.6e-18 Prudent dietary pattern; CESC cis rs7631605 0.905 rs11129752 chr3:37257793 A/G cg22985146 chr3:37219077 LRRFIP2 0.35 5.57 0.32 6.37e-8 Cerebrospinal P-tau181p levels; CESC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg11764359 chr7:65958608 NA -0.8 -12.02 -0.59 7.52e-27 Aortic root size; CESC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg20891558 chr2:74357851 NA 0.57 7.05 0.4 1.55e-11 Gestational age at birth (maternal effect); CESC cis rs57221529 0.563 rs4957057 chr5:569230 C/G cg16447950 chr5:562315 NA -0.67 -7.5 -0.42 9.39e-13 Lung disease severity in cystic fibrosis; CESC cis rs561341 0.769 rs9899093 chr17:30191954 C/G cg12193833 chr17:30244370 NA -0.58 -5.59 -0.32 5.72e-8 Hip circumference adjusted for BMI; CESC cis rs2030401 0.604 rs2682427 chr12:123656809 C/T cg00376283 chr12:123451042 ABCB9 0.38 5.04 0.3 8.49e-7 Intelligence (multi-trait analysis); CESC cis rs4704187 0.663 rs12523187 chr5:74379625 A/T cg03227963 chr5:74354835 NA 0.32 5.95 0.34 8.68e-9 Response to amphetamines; CESC cis rs73001065 0.792 rs16996148 chr19:19658472 G/T cg03709012 chr19:19516395 GATAD2A 0.94 6.62 0.38 1.99e-10 LDL cholesterol; CESC cis rs12142240 0.698 rs61519400 chr1:46855298 A/G cg10495392 chr1:46806563 NSUN4 0.56 6.15 0.35 2.86e-9 Menopause (age at onset); CESC cis rs9814567 1.000 rs4535272 chr3:134299916 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.44 5.85 0.34 1.44e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs247833 0.507 rs2013847 chr16:84587960 G/T cg06393589 chr16:84581885 NA 0.35 6.24 0.36 1.75e-9 Monocyte count; CESC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.72 0.43 2.43e-13 Prudent dietary pattern; CESC cis rs4253772 0.591 rs9615934 chr22:46682310 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.74 6.61 0.38 2.17e-10 LDL cholesterol;Cholesterol, total; CESC trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg03929089 chr4:120376271 NA -0.79 -11.88 -0.59 2.24e-26 Coronary artery disease; CESC cis rs425277 1.000 rs427811 chr1:2075560 T/G cg24578937 chr1:2090814 PRKCZ 0.55 9.47 0.5 1.62e-18 Height; CESC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.73 -8.95 -0.48 6.49e-17 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14733936 chr2:70476139 TIA1 0.59 6.34 0.36 9.97e-10 Gut microbiome composition (summer); CESC cis rs9443645 0.869 rs1567168 chr6:79536455 G/T cg05283184 chr6:79620031 NA -0.45 -6.92 -0.39 3.36e-11 Intelligence (multi-trait analysis); CESC cis rs6582630 0.555 rs11613249 chr12:38519339 T/C cg26384229 chr12:38710491 ALG10B 0.73 11.35 0.57 1.32e-24 Drug-induced liver injury (flucloxacillin); CESC cis rs11758351 0.660 rs2143345 chr6:26229148 C/T cg01420254 chr6:26195488 NA 0.77 8.48 0.46 1.59e-15 Gout;Renal underexcretion gout; CESC cis rs7727544 0.660 rs274563 chr5:131717859 C/A cg07395648 chr5:131743802 NA 0.44 5.89 0.34 1.15e-8 Blood metabolite levels; CESC cis rs7726839 0.540 rs72703095 chr5:601789 T/C cg16447950 chr5:562315 NA -0.6 -6.06 -0.35 4.78e-9 Obesity-related traits; CESC cis rs71277158 0.572 rs77964281 chr3:169916180 T/C cg04067573 chr3:169899625 PHC3 0.68 6.5 0.37 3.99e-10 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13873920 chr18:72163386 CNDP2 0.56 6.05 0.35 4.96e-9 Gut microbiome composition (summer); CESC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg05255149 chr17:80675120 FN3KRP 0.45 5.04 0.3 8.76e-7 Glycated hemoglobin levels; CESC cis rs2072732 0.821 rs12037307 chr1:2947756 C/A cg15211996 chr1:2936768 ACTRT2 0.35 5.55 0.32 6.98e-8 Plateletcrit; CESC cis rs9341835 0.518 rs2622293 chr6:64218491 T/C cg03326410 chr6:64151739 NA 0.32 5.15 0.3 5.1e-7 Schizophrenia; CESC cis rs4808199 0.948 rs12982276 chr19:19459800 T/C cg03709012 chr19:19516395 GATAD2A 1.07 12.42 0.61 3.25e-28 Nonalcoholic fatty liver disease; CESC cis rs826838 1.000 rs826886 chr12:39095797 A/G cg13010199 chr12:38710504 ALG10B 0.42 5.88 0.34 1.22e-8 Heart rate; CESC cis rs1371867 0.817 rs1660315 chr8:101332956 G/A cg11906718 chr8:101322791 RNF19A 0.53 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC cis rs8020095 0.571 rs8019510 chr14:67523915 T/C cg19548862 chr14:67692701 FAM71D -0.5 -6.2 -0.36 2.16e-9 Depression (quantitative trait); CESC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg04414720 chr1:150670196 GOLPH3L 0.51 6.76 0.38 8.61e-11 Melanoma; CESC cis rs3540 0.576 rs10152871 chr15:91047469 G/A cg22089800 chr15:90895588 ZNF774 -0.65 -8.98 -0.48 5.25e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24511898 chr2:242576823 ATG4B;THAP4 -0.46 -7.17 -0.4 7.65e-12 Gambling; CESC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg16325326 chr1:53192061 ZYG11B -0.84 -13.48 -0.64 6.62e-32 Monocyte count; CESC cis rs2880765 0.835 rs4842884 chr15:86035174 T/C cg19183879 chr15:85880815 NA -0.25 -5.3 -0.31 2.49e-7 Coronary artery disease; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg16868751 chr10:96162146 TBC1D12 -0.5 -6.44 -0.37 5.48e-10 Subjective well-being; CESC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.06 10.39 0.54 1.98e-21 Platelet count; CESC cis rs6828523 0.698 rs73869044 chr4:175852900 T/C cg14561282 chr4:175839468 ADAM29 0.43 5.07 0.3 7.33e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06824641 chr8:22298455 PPP3CC 0.59 7.17 0.4 7.39e-12 Gut microbiome composition (summer); CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg25405998 chr7:65216604 CCT6P1 0.44 5.68 0.33 3.62e-8 Calcium levels; CESC cis rs12477438 0.798 rs972768 chr2:99682397 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22225685 chr22:38203998 GCAT 0.59 7.15 0.4 8.57e-12 Gut microbiome composition (summer); CESC cis rs6493487 0.512 rs35655196 chr15:51321908 A/G cg02338191 chr15:51200825 AP4E1 0.57 5.39 0.31 1.58e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs6570726 0.935 rs421690 chr6:145834594 A/C cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs9325144 0.647 rs12831609 chr12:39051576 C/A cg26384229 chr12:38710491 ALG10B -0.52 -7.29 -0.41 3.56e-12 Morning vs. evening chronotype; CESC cis rs3747547 0.892 rs2103241 chr9:37950936 C/T cg13774184 chr9:37916125 SHB -0.62 -5.84 -0.34 1.49e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs7246657 0.943 rs10405407 chr19:37839164 C/T cg23950597 chr19:37808831 NA -0.55 -6.09 -0.35 3.96e-9 Coronary artery calcification; CESC cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.865 rs4507344 chr4:120307485 C/A cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs11098499 0.954 rs878373 chr4:120237484 A/T cg09307838 chr4:120376055 NA 0.92 12.74 0.62 2.56e-29 Corneal astigmatism; CESC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg18876405 chr7:65276391 NA 0.53 7.06 0.4 1.42e-11 Aortic root size; CESC cis rs17209837 1.000 rs45590633 chr7:87090480 C/T cg00919237 chr7:87102261 ABCB4 -0.55 -5.61 -0.33 5.09e-8 Gallbladder cancer; CESC cis rs12410462 0.681 rs6670816 chr1:227610592 G/T cg23173402 chr1:227635558 NA -0.67 -6.52 -0.37 3.64e-10 Major depressive disorder; CESC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg02034447 chr16:89574710 SPG7 0.51 6.7 0.38 1.26e-10 Multiple myeloma (IgH translocation); CESC trans rs2391518 0.639 rs2968998 chr4:130784655 A/G cg04981619 chr2:43328122 NA 0.38 6.11 0.35 3.61e-9 Body mass index; CESC trans rs208520 0.690 rs12197578 chr6:66725905 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.24 0.6 1.32e-27 Exhaled nitric oxide output; CESC cis rs6754311 0.773 rs309178 chr2:136611624 C/T cg07169764 chr2:136633963 MCM6 -0.69 -8.56 -0.47 9.42e-16 Mosquito bite size; CESC trans rs1814175 0.817 rs11518158 chr11:49985633 G/T cg15704280 chr7:45808275 SEPT13 -1.03 -20.38 -0.78 3.6e-56 Height; CESC cis rs8114671 0.836 rs6141526 chr20:33615255 G/T cg06115741 chr20:33292138 TP53INP2 -0.47 -5.59 -0.32 5.54e-8 Height; CESC cis rs9818758 0.607 rs73074866 chr3:49626666 C/T cg00383909 chr3:49044727 WDR6 0.81 5.35 0.31 1.9e-7 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC trans rs2391518 0.595 rs2969005 chr4:130781514 A/G cg04981619 chr2:43328122 NA 0.38 6.0 0.35 6.59e-9 Body mass index; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg10678486 chr18:48494218 ELAC1 -0.42 -6.06 -0.35 4.65e-9 Vertical cup-disc ratio; CESC cis rs9858542 0.903 rs9875617 chr3:49634696 G/A cg03060546 chr3:49711283 APEH -0.51 -5.93 -0.34 9.4e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg03538708 chr1:25844672 NA 0.42 6.53 0.37 3.29e-10 Plateletcrit;Mean corpuscular volume; CESC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg15445000 chr17:37608096 MED1 -0.42 -6.87 -0.39 4.46e-11 Glomerular filtration rate (creatinine); CESC trans rs4596713 0.538 rs4421408 chr9:71760884 G/T cg16512924 chr15:28394682 HERC2 0.5 6.38 0.36 7.96e-10 Headache; CESC cis rs7605827 0.897 rs1996516 chr2:15517246 G/A cg19274914 chr2:15703543 NA 0.35 6.27 0.36 1.43e-9 Educational attainment (years of education); CESC cis rs7116495 1.000 rs4338555 chr11:71755696 T/C cg10381502 chr11:71823885 C11orf51 -0.69 -5.89 -0.34 1.17e-8 Severe influenza A (H1N1) infection; CESC cis rs4604732 1.000 rs4604732 chr1:247623872 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 -0.37 -5.03 -0.3 8.9e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6500395 0.735 rs74017013 chr16:48664120 G/A cg04672837 chr16:48644449 N4BP1 0.49 6.27 0.36 1.46e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg17724175 chr1:150552817 MCL1 0.41 6.33 0.36 1.06e-9 Melanoma; CESC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 11.24 0.57 3.07e-24 Platelet count; CESC cis rs662064 0.962 rs683864 chr1:10561954 T/C cg20482658 chr1:10539492 PEX14 0.38 7.59 0.42 5.56e-13 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25332325 chr10:71906362 TYSND1 0.58 6.83 0.39 5.65e-11 Gut microbiome composition (summer); CESC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg13777783 chr17:79615861 NA -0.37 -6.2 -0.36 2.14e-9 Eye color traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18931685 chr19:45505298 RELB 0.47 6.17 0.35 2.61e-9 Gut microbiota (bacterial taxa); CESC cis rs4835473 0.663 rs1511423 chr4:144911289 T/C cg25736465 chr4:144833511 NA 0.42 6.39 0.37 7.37e-10 Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09648315 chr5:65892099 MAST4 0.48 6.04 0.35 5.32e-9 Gut microbiome composition (summer); CESC cis rs4843185 0.516 rs374029 chr16:85725953 G/A cg05245094 chr16:85669572 KIAA0182 0.41 5.05 0.3 8.12e-7 Platelet distribution width; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg12232852 chr3:69129018 UBA3 -0.5 -7.38 -0.41 2.04e-12 Gambling; CESC trans rs7615952 0.641 rs4490307 chr3:125712676 T/G cg07211511 chr3:129823064 LOC729375 -0.58 -6.92 -0.39 3.3e-11 Blood pressure (smoking interaction); CESC cis rs17253792 0.822 rs8009608 chr14:56062590 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs6499129 1.000 rs6499129 chr16:67458251 A/C cg26727032 chr16:67993705 SLC12A4 -0.57 -6.01 -0.35 5.97e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg03467027 chr4:99064603 C4orf37 0.42 5.04 0.3 8.53e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3815700 1.000 rs3815700 chr19:33093252 T/C cg02997394 chr19:33096574 ANKRD27 0.73 7.3 0.41 3.26e-12 Eosinophilic esophagitis; CESC cis rs4478858 0.775 rs6701861 chr1:31708125 A/C cg00250761 chr1:31883323 NA -0.27 -5.35 -0.31 1.9e-7 Alcohol dependence; CESC cis rs13095912 0.785 rs6800725 chr3:185298156 C/A cg11274856 chr3:185301563 NA 0.38 5.72 0.33 2.9e-8 Systolic blood pressure; CESC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg11663144 chr21:46675770 NA -0.63 -9.9 -0.52 7.47e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10504229 0.679 rs72649114 chr8:58037491 G/T cg24829409 chr8:58192753 C8orf71 -0.49 -6.15 -0.35 2.91e-9 Developmental language disorder (linguistic errors); CESC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg00149659 chr3:10157352 C3orf10 -0.74 -9.19 -0.49 1.15e-17 Alzheimer's disease; CESC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg02753203 chr1:228287806 NA -0.58 -8.55 -0.46 1.02e-15 Diastolic blood pressure; CESC cis rs34779708 0.966 rs2045917 chr10:35418526 G/A cg03585969 chr10:35415529 CREM 0.76 10.09 0.53 1.79e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08077726 chr17:74734280 SFRS2;MFSD11 -0.42 -6.22 -0.36 1.95e-9 Gambling; CESC cis rs9815354 0.812 rs55916855 chr3:42002761 A/G cg03022575 chr3:42003672 ULK4 0.66 5.77 0.33 2.17e-8 Pulse pressure;Diastolic blood pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03705947 chr1:68152081 GADD45A -0.43 -6.39 -0.37 7.5e-10 Gambling; CESC cis rs763121 0.889 rs9607557 chr22:39040279 G/A cg06022373 chr22:39101656 GTPBP1 0.89 15.16 0.68 8.51e-38 Menopause (age at onset); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg27003951 chr16:11350045 SOCS1 0.45 6.2 0.36 2.16e-9 Breast cancer;Type 2 diabetes; CESC cis rs9916302 0.904 rs11078915 chr17:37715426 T/C cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs2820292 0.741 rs12086240 chr1:201885791 G/A cg06775570 chr1:201857621 SHISA4 -0.34 -5.8 -0.34 1.85e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg06212747 chr3:49208901 KLHDC8B 0.66 8.74 0.47 2.71e-16 Parkinson's disease; CESC cis rs28489187 0.643 rs997251 chr1:85845367 T/C cg16011679 chr1:85725395 C1orf52 0.53 6.17 0.35 2.49e-9 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs9910055 0.573 rs113184718 chr17:42206543 A/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.64 -8.55 -0.46 1.01e-15 Total body bone mineral density; CESC cis rs2242663 0.531 rs2511225 chr11:66248431 A/C cg04006266 chr11:66300458 BBS1 0.34 5.42 0.32 1.36e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26381048 chr12:132632420 NOC4L -0.54 -6.28 -0.36 1.37e-9 Gut microbiome composition (summer); CESC cis rs3749237 0.555 rs2117939 chr3:49415179 C/A cg06212747 chr3:49208901 KLHDC8B 0.49 6.6 0.38 2.22e-10 Resting heart rate; CESC cis rs1008375 0.966 rs4235389 chr4:17696280 A/G cg16339924 chr4:17578868 LAP3 0.52 6.62 0.38 2.03e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs910316 1.000 rs28626045 chr14:75589195 G/C cg16144293 chr14:75469539 EIF2B2 -0.4 -5.21 -0.3 3.82e-7 Height; CESC cis rs10870270 0.917 rs9971362 chr10:133790150 T/C cg08754478 chr10:133766260 PPP2R2D -0.56 -7.08 -0.4 1.29e-11 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs698833 0.798 rs4953082 chr2:44524064 G/A cg04920474 chr2:44395004 PPM1B 0.39 5.57 0.32 6.24e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs6963495 0.719 rs73190174 chr7:105161216 T/G cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg11965913 chr1:205819406 PM20D1 0.81 12.67 0.61 4.26e-29 Menarche (age at onset); CESC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg09699651 chr6:150184138 LRP11 0.4 5.09 0.3 6.7e-7 Lung cancer; CESC cis rs6662572 0.806 rs56067046 chr1:46044314 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 5.68 0.33 3.51e-8 Blood protein levels; CESC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg00166722 chr3:10149974 C3orf24 0.44 5.39 0.31 1.54e-7 Alzheimer's disease; CESC cis rs8064299 0.597 rs9944506 chr17:72782726 C/G cg25054828 chr17:72772726 NAT9;TMEM104 0.85 14.36 0.66 5.44e-35 Monocyte count; CESC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.85 0.34 1.46e-8 Bipolar disorder; CESC cis rs523522 0.962 rs3742052 chr12:120966921 A/G cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC trans rs57221529 0.766 rs72703075 chr5:592819 C/T cg25482853 chr8:67687455 SGK3 1.08 9.89 0.52 7.84e-20 Lung disease severity in cystic fibrosis; CESC cis rs7208859 0.623 rs73271842 chr17:29137155 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7617773 0.817 rs4131362 chr3:48329036 A/C cg11946769 chr3:48343235 NME6 0.8 10.89 0.56 4.71e-23 Coronary artery disease; CESC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg11644478 chr21:40555479 PSMG1 -0.54 -7.3 -0.41 3.41e-12 Menarche (age at onset); CESC cis rs2299587 0.607 rs2237848 chr8:17874604 A/C cg08627089 chr8:17753878 FGL1 -0.38 -5.19 -0.3 4.22e-7 Economic and political preferences; CESC cis rs9325144 0.723 rs11169535 chr12:39183494 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.23 -0.41 5.23e-12 Morning vs. evening chronotype; CESC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg22105103 chr4:187893119 NA 0.49 7.24 0.41 4.79e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg18876405 chr7:65276391 NA 0.49 6.55 0.37 3e-10 Aortic root size; CESC cis rs6973256 0.583 rs2430768 chr7:133340287 T/C cg10665199 chr7:133106180 EXOC4 -0.45 -6.13 -0.35 3.17e-9 Intelligence (multi-trait analysis); CESC cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg10523679 chr1:76189770 ACADM 0.71 8.23 0.45 8.39e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3020736 0.500 rs8138678 chr22:42516229 A/G cg15557168 chr22:42548783 NA 0.45 6.43 0.37 5.91e-10 Autism spectrum disorder or schizophrenia; CESC cis rs60154123 0.772 rs845452 chr1:210417861 C/T cg25204440 chr1:209979598 IRF6 0.49 5.12 0.3 5.85e-7 Coronary artery disease; CESC cis rs432925 0.600 rs214249 chr16:348687 T/G cg06233593 chr16:337645 AXIN1 0.49 7.48 0.42 1.12e-12 Morning vs. evening chronotype; CESC cis rs61931739 0.857 rs999715 chr12:34143253 G/C cg19457237 chr12:34500585 NA -0.36 -5.06 -0.3 7.79e-7 Morning vs. evening chronotype; CESC cis rs2046867 0.862 rs75638790 chr3:72830502 C/T cg25664220 chr3:72788482 NA -0.44 -6.23 -0.36 1.78e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs6740322 0.748 rs13432574 chr2:43544328 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.71 -7.66 -0.43 3.57e-13 Coronary artery disease; CESC cis rs992157 0.560 rs12987130 chr2:219104990 T/C cg00012203 chr2:219082015 ARPC2 -0.76 -10.12 -0.53 1.46e-20 Colorectal cancer; CESC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg27535305 chr1:53392650 SCP2 0.33 5.63 0.33 4.59e-8 Monocyte count; CESC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg18758796 chr5:131593413 PDLIM4 0.48 6.96 0.39 2.71e-11 Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10318825 chr7:75611554 POR -0.52 -6.1 -0.35 3.84e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg26354017 chr1:205819088 PM20D1 0.44 5.63 0.33 4.55e-8 Parkinson's disease; CESC cis rs13256369 0.802 rs12153 chr8:8560909 G/C cg00074818 chr8:8560427 CLDN23 0.36 5.22 0.31 3.68e-7 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06484986 chr15:42841099 LRRC57;HAUS2 0.57 6.68 0.38 1.38e-10 Gut microbiome composition (summer); CESC cis rs8038465 1.000 rs67257650 chr15:73979507 C/T cg15420318 chr15:73925796 NPTN 0.43 6.05 0.35 4.94e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.9 10.01 0.52 3.13e-20 Mean platelet volume; CESC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg03388025 chr16:89894329 SPIRE2 -0.41 -7.68 -0.43 3.12e-13 Vitiligo; CESC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg08027265 chr7:2291960 NA 0.42 6.41 0.37 6.45e-10 Bipolar disorder and schizophrenia; CESC cis rs7937682 0.924 rs495460 chr11:111504777 G/A cg22437258 chr11:111473054 SIK2 0.7 9.35 0.5 3.83e-18 Primary sclerosing cholangitis; CESC cis rs10744422 0.843 rs3896870 chr12:123333611 T/C cg25930673 chr12:123319894 HIP1R -0.73 -5.71 -0.33 3.02e-8 Schizophrenia; CESC cis rs709400 1.000 rs2403205 chr14:104143385 C/T cg24130564 chr14:104152367 KLC1 -0.43 -5.48 -0.32 9.93e-8 Body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24008668 chr6:26158556 HIST1H2BD 0.46 6.04 0.35 5.27e-9 Gut microbiota (bacterial taxa); CESC cis rs9790314 1.000 rs464766 chr3:161087592 C/G cg03342759 chr3:160939853 NMD3 -0.44 -5.6 -0.33 5.25e-8 Morning vs. evening chronotype; CESC cis rs6998277 0.830 rs6981007 chr8:103598257 G/C cg10187029 chr8:103597600 NA 0.75 9.93 0.52 5.94e-20 Migraine; CESC cis rs4699052 0.739 rs11936824 chr4:104238003 T/G cg16532752 chr4:104119610 CENPE -0.37 -5.25 -0.31 3.09e-7 Testicular germ cell tumor; CESC cis rs9487051 0.738 rs449850 chr6:109525045 A/G cg01475377 chr6:109611718 NA -0.46 -6.93 -0.39 3.27e-11 Reticulocyte fraction of red cells; CESC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg05368731 chr17:41323189 NBR1 0.8 10.68 0.55 2.21e-22 Menopause (age at onset); CESC cis rs9486719 1.000 rs11757063 chr6:96884886 C/T cg18709589 chr6:96969512 KIAA0776 -0.53 -5.87 -0.34 1.3e-8 Migraine;Coronary artery disease; CESC cis rs7089973 0.584 rs6585300 chr10:116639889 A/C cg25233709 chr10:116636983 FAM160B1 0.39 6.38 0.36 7.78e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs939574 0.790 rs72955444 chr2:220094673 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.88 7.38 0.41 2e-12 Platelet distribution width; CESC cis rs9815354 0.812 rs55788971 chr3:41843965 T/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs56046484 0.620 rs34585903 chr15:85528124 G/T cg08123816 chr15:85640762 PDE8A -0.48 -5.14 -0.3 5.46e-7 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg05340658 chr4:99064831 C4orf37 -0.85 -12.75 -0.62 2.33e-29 Colonoscopy-negative controls vs population controls; CESC cis rs4595586 0.545 rs11610886 chr12:39390613 C/G cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs1801251 1.000 rs2044449 chr2:233718808 G/A cg08000102 chr2:233561755 GIGYF2 -0.7 -10.07 -0.53 2.13e-20 Coronary artery disease; CESC cis rs10751667 0.666 rs7944815 chr11:959776 C/T cg01483505 chr11:975446 AP2A2 0.37 5.09 0.3 6.77e-7 Alzheimer's disease (late onset); CESC cis rs854765 0.583 rs7214002 chr17:17852104 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 6.08 0.35 4.28e-9 Total body bone mineral density; CESC cis rs12476592 0.602 rs262505 chr2:63861786 C/T cg17519650 chr2:63277830 OTX1 -0.46 -5.08 -0.3 6.98e-7 Childhood ear infection; CESC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg06481639 chr22:41940642 POLR3H -0.63 -6.42 -0.37 6.29e-10 Vitiligo; CESC cis rs899997 1.000 rs12899940 chr15:79001699 A/G cg04896959 chr15:78267971 NA -0.46 -7.26 -0.41 4.36e-12 Coronary artery disease or large artery stroke; CESC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg22535103 chr8:58192502 C8orf71 -0.63 -6.61 -0.38 2.09e-10 Developmental language disorder (linguistic errors); CESC cis rs936229 0.690 rs2472299 chr15:75033400 C/T cg14664628 chr15:75095509 CSK 0.8 10.81 0.55 8.21e-23 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs9486719 0.843 rs2205754 chr6:96843134 T/C cg06623918 chr6:96969491 KIAA0776 0.78 7.39 0.41 1.89e-12 Migraine;Coronary artery disease; CESC cis rs13114435 0.723 rs3886768 chr4:183817324 A/G cg00486011 chr4:183851557 NA -0.37 -5.49 -0.32 9.23e-8 Obesity-related traits; CESC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.91 0.34 1.03e-8 Tonsillectomy; CESC cis rs2073300 0.609 rs17757442 chr20:23421101 A/G cg16736954 chr20:23401023 NAPB -0.8 -6.31 -0.36 1.18e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2996428 0.709 rs6424052 chr1:3713746 A/G cg23277830 chr1:3704460 LRRC47 0.36 5.2 0.3 3.91e-7 Red cell distribution width; CESC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg23708337 chr7:1209742 NA 0.49 5.13 0.3 5.69e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18778933 chr5:52760204 NA 0.5 6.1 0.35 3.68e-9 Gut microbiome composition (summer); CESC cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.44 -7.16 -0.4 7.77e-12 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs208520 0.837 rs208488 chr6:66926902 C/T cg07460842 chr6:66804631 NA -0.9 -10.93 -0.56 3.28e-23 Exhaled nitric oxide output; CESC cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg05585544 chr11:47624801 NA -0.5 -7.57 -0.42 6.07e-13 Subjective well-being; CESC cis rs9467773 0.620 rs3800303 chr6:26598188 A/G cg26531700 chr6:26746687 NA -0.42 -6.42 -0.37 6.13e-10 Intelligence (multi-trait analysis); CESC cis rs7937682 0.889 rs1940529 chr11:111498523 G/C cg22437258 chr11:111473054 SIK2 0.7 9.08 0.49 2.59e-17 Primary sclerosing cholangitis; CESC cis rs735396 0.770 rs2259820 chr12:121435342 C/T cg02403541 chr12:121454288 C12orf43 0.73 10.33 0.54 2.99e-21 N-glycan levels; CESC cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg25019033 chr10:957182 NA -0.56 -6.09 -0.35 3.92e-9 Eosinophil percentage of granulocytes; CESC cis rs2072499 0.900 rs2248080 chr1:156195971 T/A cg25208724 chr1:156163844 SLC25A44 0.95 15.17 0.68 7.91e-38 Testicular germ cell tumor; CESC cis rs2073300 0.609 rs6132609 chr20:23400412 A/C cg12062639 chr20:23401060 NAPB 1.07 8.23 0.45 8.58e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.93 13.67 0.64 1.54e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24351916 chr3:39452635 SNORA62;RPSA -0.52 -6.2 -0.36 2.21e-9 Gut microbiome composition (summer); CESC cis rs9291683 0.620 rs4444830 chr4:10124819 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -7.93 -0.44 5.99e-14 Bone mineral density; CESC cis rs4604732 0.578 rs7525209 chr1:247627404 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg17158414 chr2:27665306 KRTCAP3 -0.36 -6.47 -0.37 4.8e-10 Total body bone mineral density; CESC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.44 0.64 9.54e-32 Prudent dietary pattern; CESC trans rs116095464 0.558 rs10057674 chr5:266813 C/T cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.38e-11 Breast cancer; CESC trans rs2727020 0.521 rs1909220 chr11:49572109 T/C cg03929089 chr4:120376271 NA -0.73 -8.46 -0.46 1.79e-15 Coronary artery disease; CESC cis rs8060686 0.641 rs28548264 chr16:68211321 A/G cg26727032 chr16:67993705 SLC12A4 -0.51 -6.18 -0.36 2.35e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg22143856 chr6:28129313 ZNF389 0.49 6.28 0.36 1.38e-9 Depression; CESC cis rs761746 0.960 rs4820983 chr22:31929654 C/T cg25791279 chr22:32026902 PISD -0.46 -5.34 -0.31 2e-7 Intelligence; CESC cis rs1878931 0.624 rs39728 chr16:3453076 A/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.73 9.42 0.5 2.26e-18 Body mass index (adult); CESC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg24562669 chr7:97807699 LMTK2 0.49 7.17 0.4 7.33e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs9908102 0.740 rs4791522 chr17:12902688 C/G cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs3820068 0.581 rs72645861 chr1:15920314 A/G cg17385448 chr1:15911702 AGMAT 0.42 6.72 0.38 1.13e-10 Systolic blood pressure; CESC cis rs11098499 0.954 rs59394118 chr4:120295551 A/G cg24375607 chr4:120327624 NA 0.47 5.62 0.33 4.89e-8 Corneal astigmatism; CESC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.53 -0.42 7.92e-13 Gut microbiome composition (summer); CESC cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.36 5.88 0.34 1.21e-8 Monocyte percentage of white cells; CESC cis rs2191566 0.960 rs11083732 chr19:44520743 T/C cg20607764 chr19:44506953 ZNF230 -0.57 -7.45 -0.42 1.29e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs4523957 0.583 rs923863 chr17:2031387 A/G cg16513277 chr17:2031491 SMG6 -0.79 -11.73 -0.58 6.95e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11153306 0.791 rs9387017 chr6:111944006 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.4 -6.03 -0.35 5.42e-9 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10137979 chr8:110346498 ENY2;NUDCD1 0.51 6.01 0.35 6.22e-9 Gut microbiome composition (summer); CESC cis rs12142240 0.698 rs56344958 chr1:46814518 G/A cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg14416269 chr4:6271139 WFS1 -0.45 -7.5 -0.42 9.93e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs748404 0.697 rs1814323 chr15:43563237 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.51 -7.93 -0.44 6.18e-14 Lung cancer; CESC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg22968622 chr17:43663579 NA -0.75 -10.16 -0.53 1.05e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9611565 0.649 rs139540 chr22:42178040 C/T cg06634786 chr22:41940651 POLR3H -0.48 -5.41 -0.32 1.41e-7 Vitiligo; CESC cis rs4595586 0.756 rs1400283 chr12:39364596 G/C cg26384229 chr12:38710491 ALG10B 0.42 6.21 0.36 2.07e-9 Morning vs. evening chronotype; CESC cis rs2832191 0.716 rs1543652 chr21:30448000 G/C cg24692254 chr21:30365293 RNF160 0.99 17.29 0.73 2.32e-45 Dental caries; CESC cis rs4901847 0.577 rs10782436 chr14:58574964 T/C cg15908186 chr14:58618357 C14orf37 0.38 5.71 0.33 2.95e-8 Lupus nephritis in systemic lupus erythematosus; CESC cis rs2882667 0.858 rs11242448 chr5:138443154 C/A cg04439458 chr5:138467593 SIL1 -0.39 -6.11 -0.35 3.51e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs11098499 0.954 rs2389803 chr4:120393511 A/G cg09307838 chr4:120376055 NA -0.94 -13.85 -0.65 3.54e-33 Corneal astigmatism; CESC cis rs7084402 0.967 rs1427196 chr10:60278573 C/T cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC cis rs9925964 0.967 rs12716981 chr16:31118024 C/A cg02466173 chr16:30829666 NA 0.33 5.16 0.3 4.77e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs14403 1.000 rs67027895 chr1:243667216 C/T cg21452805 chr1:244014465 NA 0.45 5.32 0.31 2.23e-7 Schizophrenia; CESC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg07157834 chr1:205819609 PM20D1 -0.4 -5.36 -0.31 1.77e-7 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs735539 1.000 rs6490605 chr13:21285009 C/T cg04906043 chr13:21280425 IL17D -0.35 -5.52 -0.32 8.25e-8 Dental caries; CESC trans rs11098499 0.874 rs28452522 chr4:120110784 A/G cg25214090 chr10:38739885 LOC399744 0.55 7.2 0.4 6.26e-12 Corneal astigmatism; CESC cis rs1865721 0.804 rs62089468 chr18:73158850 C/T cg26385618 chr18:73139727 C18orf62 -0.46 -6.98 -0.39 2.32e-11 Intelligence; CESC cis rs9388451 0.626 rs7748729 chr6:126077381 C/T cg05901451 chr6:126070800 HEY2 -0.61 -9.13 -0.49 1.79e-17 Brugada syndrome; CESC trans rs7944735 0.507 rs10838802 chr11:48102478 A/G cg03929089 chr4:120376271 NA 0.55 6.77 0.38 8.46e-11 Intraocular pressure; CESC cis rs1023500 0.573 rs133381 chr22:42470608 C/G cg15557168 chr22:42548783 NA -0.44 -6.02 -0.35 5.64e-9 Schizophrenia; CESC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg17376030 chr22:41985996 PMM1 0.68 7.52 0.42 8.57e-13 Vitiligo; CESC cis rs7193541 0.684 rs4887783 chr16:74700743 G/C cg05580060 chr16:74700937 RFWD3 -0.42 -5.39 -0.31 1.6e-7 Multiple myeloma; CESC cis rs7084402 0.967 rs1658419 chr10:60332812 A/C cg07615347 chr10:60278583 BICC1 0.59 9.22 0.49 9.9e-18 Refractive error; CESC cis rs11760633 0.607 rs11761457 chr7:1829228 C/T cg23422044 chr7:1970798 MAD1L1 -0.42 -5.1 -0.3 6.6e-7 Coronary artery disease; CESC cis rs870825 0.616 rs6552802 chr4:185620751 C/G cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18644787 chr2:208890461 PLEKHM3 -0.45 -6.15 -0.35 2.87e-9 Gut microbiota (bacterial taxa); CESC cis rs7216064 0.953 rs62086044 chr17:65970837 G/T cg12091567 chr17:66097778 LOC651250 -0.76 -8.1 -0.45 2.02e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs3784262 0.967 rs35511675 chr15:58266978 T/A cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.07 -0.3 7.57e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs1707322 1.000 rs946527 chr1:46485970 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.56 0.32 6.73e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg22105103 chr4:187893119 NA 0.46 6.88 0.39 4.28e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7208859 0.623 rs28433704 chr17:29084285 G/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2635047 0.656 rs1355594 chr18:44763994 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 5.62 0.33 4.79e-8 Educational attainment; CESC cis rs644799 0.542 rs10831415 chr11:95466159 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.5 6.43 0.37 5.86e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7726839 0.540 rs28364691 chr5:664084 G/A cg16447950 chr5:562315 NA -0.62 -6.54 -0.37 3.09e-10 Obesity-related traits; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg09299307 chr5:86709023 CCNH 0.48 6.26 0.36 1.58e-9 Obesity-related traits; CESC cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg26597838 chr10:835615 NA 0.7 8.31 0.45 5.1e-15 Eosinophil percentage of granulocytes; CESC trans rs2727020 0.729 rs588458 chr11:49214048 C/A cg15704280 chr7:45808275 SEPT13 0.85 14.02 0.65 8.72e-34 Coronary artery disease; CESC cis rs9905704 0.633 rs2680697 chr17:56478711 T/A cg12560992 chr17:57184187 TRIM37 -0.61 -5.75 -0.33 2.49e-8 Testicular germ cell tumor; CESC cis rs17376456 0.877 rs12374470 chr5:93481046 A/G cg25358565 chr5:93447407 FAM172A 1.15 10.91 0.56 3.79e-23 Diabetic retinopathy; CESC cis rs12145833 0.596 rs12134228 chr1:243447618 C/T cg02356786 chr1:243265016 LOC731275 0.72 5.23 0.31 3.48e-7 Obesity (early onset extreme); CESC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg26314531 chr2:26401878 FAM59B 0.7 7.47 0.42 1.17e-12 Gut microbiome composition (summer); CESC cis rs2637266 0.935 rs2583057 chr10:78396019 C/T cg18941641 chr10:78392320 NA 0.45 8.6 0.47 7.12e-16 Pulmonary function; CESC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg22549504 chr19:17448937 GTPBP3 0.49 5.46 0.32 1.12e-7 Systemic lupus erythematosus; CESC cis rs7927771 0.757 rs1057233 chr11:47376448 G/A cg20307385 chr11:47447363 PSMC3 0.61 7.29 0.41 3.51e-12 Subjective well-being; CESC cis rs9487051 0.735 rs351745 chr6:109529169 C/T cg01475377 chr6:109611718 NA 0.4 5.98 0.35 7.01e-9 Reticulocyte fraction of red cells; CESC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.48 7.19 0.4 6.56e-12 Total body bone mineral density; CESC cis rs67478160 0.619 rs11623546 chr14:104269098 A/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.79 0.55 9.69e-23 Schizophrenia; CESC cis rs761746 0.960 rs4820982 chr22:31929480 T/C cg25791279 chr22:32026902 PISD -0.47 -5.59 -0.32 5.65e-8 Intelligence; CESC cis rs992157 0.710 rs56364928 chr2:219059058 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.67 9.23 0.49 8.83e-18 Colorectal cancer; CESC trans rs7938889 0.517 rs505689 chr11:95930072 A/G cg20932348 chr4:26862197 STIM2 0.46 6.17 0.35 2.51e-9 Methadone dose in opioid dependence; CESC cis rs3733585 0.699 rs17245723 chr4:9962218 A/T cg02734326 chr4:10020555 SLC2A9 -0.44 -6.15 -0.35 2.85e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs432925 0.600 rs214247 chr16:349221 A/G cg06233593 chr16:337645 AXIN1 0.49 7.62 0.42 4.51e-13 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.66 0.64 1.57e-32 Prudent dietary pattern; CESC cis rs7618501 1.000 rs7372730 chr3:49790682 C/G cg24308560 chr3:49941425 MST1R 0.5 6.71 0.38 1.15e-10 Intelligence (multi-trait analysis); CESC cis rs4481887 0.741 rs6681758 chr1:248540413 T/A cg26353448 chr1:248524236 OR2T4 -0.39 -5.35 -0.31 1.94e-7 Common traits (Other); CESC cis rs6120849 0.754 rs6120813 chr20:33642112 T/C cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs4450798 0.649 rs59100699 chr3:13791438 A/G cg23332027 chr3:13681764 NA 0.38 5.13 0.3 5.63e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg20307385 chr11:47447363 PSMC3 -0.65 -7.57 -0.42 6.2e-13 Subjective well-being; CESC cis rs9309473 0.948 rs6719753 chr2:73749054 T/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.04 -0.35 5.24e-9 Metabolite levels; CESC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg04369109 chr6:150039330 LATS1 -0.43 -6.09 -0.35 3.99e-9 Lung cancer; CESC cis rs7520050 0.801 rs6703960 chr1:46232723 C/T cg03146154 chr1:46216737 IPP -0.5 -6.6 -0.38 2.2e-10 Red blood cell count;Reticulocyte count; CESC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg00745463 chr17:30367425 LRRC37B 0.57 5.68 0.33 3.63e-8 Hip circumference adjusted for BMI; CESC cis rs910316 0.967 rs175432 chr14:75615246 C/G cg11812906 chr14:75593930 NEK9 -0.9 -15.54 -0.69 3.63e-39 Height; CESC cis rs4523957 0.690 rs7213715 chr17:2093511 A/T cg16513277 chr17:2031491 SMG6 -0.72 -9.79 -0.52 1.63e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg24060327 chr5:131705240 SLC22A5 -0.74 -8.94 -0.48 6.87e-17 Breast cancer; CESC cis rs2073300 0.609 rs6137937 chr20:23385419 G/A cg16736954 chr20:23401023 NAPB 0.8 6.25 0.36 1.67e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg22903657 chr4:1355424 KIAA1530 -0.38 -5.13 -0.3 5.55e-7 Obesity-related traits; CESC cis rs1670533 0.932 rs935968 chr4:1063187 G/T cg27284194 chr4:1044797 NA 0.45 5.73 0.33 2.67e-8 Recombination rate (females); CESC cis rs9341808 0.667 rs2505929 chr6:80834208 A/G cg08355045 chr6:80787529 NA 0.33 5.36 0.31 1.81e-7 Sitting height ratio; CESC cis rs9467711 0.790 rs13195401 chr6:26463574 G/T cg21479132 chr6:26055353 NA 0.82 5.71 0.33 3.05e-8 Autism spectrum disorder or schizophrenia; CESC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg18404041 chr3:52824283 ITIH1 -0.36 -5.52 -0.32 8.1e-8 Bipolar disorder; CESC cis rs708547 0.647 rs1277308 chr4:57897864 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.52 7.21 0.41 5.73e-12 Response to bleomycin (chromatid breaks); CESC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg00149659 chr3:10157352 C3orf10 0.74 9.26 0.49 7.35e-18 Alzheimer's disease; CESC cis rs3936840 0.752 rs2181343 chr14:102993303 A/C cg18135206 chr14:102964638 TECPR2 -0.47 -6.18 -0.35 2.47e-9 Plateletcrit; CESC cis rs6912958 1.000 rs6454630 chr6:88171357 C/G cg12350822 chr6:88032061 C6orf162;GJB7 0.3 5.1 0.3 6.43e-7 Monocyte percentage of white cells; CESC cis rs13242816 1.000 rs62471189 chr7:116101588 G/A cg04696780 chr7:116139425 CAV2 -0.62 -5.69 -0.33 3.31e-8 P wave duration; CESC cis rs3857067 0.806 rs9996975 chr4:95101338 C/G cg11021082 chr4:95130006 SMARCAD1 -0.59 -8.69 -0.47 3.91e-16 QT interval; CESC cis rs6088590 0.931 rs6088624 chr20:33436852 T/A cg06115741 chr20:33292138 TP53INP2 0.61 7.66 0.43 3.46e-13 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18788524 chr1:145096602 SEC22B 0.67 7.58 0.42 5.67e-13 Gut microbiome composition (summer); CESC cis rs735396 0.770 rs2259820 chr12:121435342 C/T cg25281562 chr12:121454272 C12orf43 0.53 6.79 0.38 7.44e-11 N-glycan levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20299236 chr22:32870557 FBXO7 0.48 6.34 0.36 1.01e-9 Gut microbiota (bacterial taxa); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09235138 chr15:40987404 RAD51 0.47 6.56 0.37 2.79e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2120019 0.938 rs1867150 chr15:75321139 T/C cg17294928 chr15:75287854 SCAMP5 -0.77 -9.0 -0.48 4.47e-17 Blood trace element (Zn levels); CESC cis rs546131 0.890 rs496558 chr11:34826425 C/T cg06937548 chr11:34938143 PDHX;APIP 0.49 6.13 0.35 3.1e-9 Lung disease severity in cystic fibrosis; CESC cis rs9660992 0.573 rs1318187 chr1:205206172 T/A cg21643547 chr1:205240462 TMCC2 -0.39 -5.37 -0.31 1.76e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg20243544 chr17:37824526 PNMT 0.48 6.03 0.35 5.4e-9 Glomerular filtration rate (creatinine); CESC cis rs2204008 0.818 rs7313608 chr12:38383428 C/A cg26384229 chr12:38710491 ALG10B -0.67 -9.96 -0.52 4.67e-20 Bladder cancer; CESC cis rs7674212 0.539 rs6821617 chr4:104128410 G/A cg16532752 chr4:104119610 CENPE -0.39 -5.3 -0.31 2.43e-7 Type 2 diabetes; CESC cis rs9811920 0.683 rs813218 chr3:99592596 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.4 6.49 0.37 4.14e-10 Axial length; CESC trans rs62103177 1.000 rs62103177 chr18:77624479 G/A cg05926928 chr17:57297772 GDPD1 1.14 9.97 0.52 4.45e-20 Opioid sensitivity; CESC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.62 6.4 0.37 7.19e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs7178375 1.000 rs1474381 chr15:31214991 T/C cg04373760 chr16:53404718 NA 0.54 7.24 0.41 4.94e-12 Hypertriglyceridemia; CESC cis rs7772486 0.686 rs9399565 chr6:146081906 G/T cg23711669 chr6:146136114 FBXO30 -0.87 -12.87 -0.62 9.2e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs909002 0.849 rs6664789 chr1:32072406 C/G cg13919466 chr1:32135498 COL16A1 -0.47 -8.44 -0.46 2.13e-15 Intelligence (multi-trait analysis); CESC cis rs3738443 0.545 rs12566906 chr1:247388206 G/T cg07706540 chr1:247373924 NA -0.45 -5.51 -0.32 8.4e-8 Alcohol dependence; CESC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg12963246 chr6:28129442 ZNF389 0.48 6.69 0.38 1.34e-10 Parkinson's disease; CESC cis rs7208859 0.623 rs7208088 chr17:29143667 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs116095464 0.558 rs62347677 chr5:227453 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.69 0.33 3.42e-8 Breast cancer; CESC trans rs11098499 0.754 rs11098502 chr4:120252063 T/A cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg14926445 chr8:58193284 C8orf71 -0.49 -5.21 -0.3 3.76e-7 Developmental language disorder (linguistic errors); CESC cis rs10392 0.571 rs4812350 chr20:37631192 C/T cg27552599 chr20:37590471 DHX35 0.39 5.76 0.33 2.31e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs713587 0.967 rs713586 chr2:25158008 A/G cg01884057 chr2:25150051 NA 0.42 8.13 0.45 1.61e-14 Body mass index in non-asthmatics; CESC cis rs709400 1.000 rs861536 chr14:104167564 A/G cg24130564 chr14:104152367 KLC1 -0.44 -5.59 -0.32 5.67e-8 Body mass index; CESC cis rs858239 1.000 rs858240 chr7:23284237 A/G cg23682824 chr7:23144976 KLHL7 0.42 5.51 0.32 8.68e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7098414 0.511 rs10788603 chr10:82148137 G/T cg00277334 chr10:82204260 NA -0.54 -8.0 -0.44 3.82e-14 Post bronchodilator FEV1; CESC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg08859206 chr1:53392774 SCP2 0.53 7.09 0.4 1.19e-11 Monocyte count; CESC cis rs7520050 0.902 rs4638056 chr1:46458153 T/G cg03146154 chr1:46216737 IPP -0.48 -6.16 -0.35 2.71e-9 Red blood cell count;Reticulocyte count; CESC cis rs2479724 0.935 rs7753507 chr6:41784094 C/T cg08135965 chr6:41755394 TOMM6 -0.4 -5.57 -0.32 6.12e-8 Menarche (age at onset); CESC cis rs533581 0.873 rs579740 chr16:88973937 A/G cg16701003 chr16:89028210 CBFA2T3 -0.57 -8.26 -0.45 6.79e-15 Social autistic-like traits; CESC cis rs6540556 0.769 rs12030655 chr1:209922123 G/T cg23920097 chr1:209922102 NA -0.38 -5.42 -0.32 1.37e-7 Red blood cell count; CESC cis rs2072499 0.966 rs2244144 chr1:156184598 G/A cg24450063 chr1:156163899 SLC25A44 0.92 14.14 0.66 3.37e-34 Testicular germ cell tumor; CESC cis rs950169 1.000 rs12902672 chr15:84716986 G/A cg17507749 chr15:85114479 UBE2QP1 0.63 6.93 0.39 3.26e-11 Schizophrenia; CESC cis rs9611565 0.559 rs12483860 chr22:41961916 C/T cg06634786 chr22:41940651 POLR3H -0.62 -6.83 -0.39 5.85e-11 Vitiligo; CESC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.02 0.48 3.87e-17 Tonsillectomy; CESC cis rs8068544 0.818 rs78333491 chr17:40163138 A/G cg26502583 chr17:39992600 KLHL10;NT5C3L -0.76 -6.07 -0.35 4.34e-9 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs9611565 0.649 rs6002480 chr22:42176917 A/T cg06481639 chr22:41940642 POLR3H -0.49 -5.64 -0.33 4.39e-8 Vitiligo; CESC cis rs2984613 1 rs2984613 chr1:156197380 C/T cg24450063 chr1:156163899 SLC25A44 0.8 11.76 0.59 5.75e-26 Intracerebral hemorrhage;White matter hyperintensity burden; CESC cis rs1707322 0.752 rs6658700 chr1:46160260 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs703842 1.000 rs10877019 chr12:58172929 A/G cg00677455 chr12:58241039 CTDSP2 -0.49 -6.09 -0.35 3.98e-9 Multiple sclerosis; CESC cis rs3806843 0.900 rs2563286 chr5:140125199 T/A cg26395211 chr5:140044315 WDR55 0.39 5.14 0.3 5.35e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6964587 0.934 rs73226382 chr7:91692760 T/C cg17063962 chr7:91808500 NA 0.6 8.37 0.46 3.39e-15 Breast cancer; CESC cis rs11048434 0.761 rs2110191 chr12:9136263 G/A cg23795048 chr12:9217529 LOC144571 0.35 5.37 0.31 1.76e-7 Sjögren's syndrome; CESC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -11.51 -0.58 3.94e-25 Initial pursuit acceleration; CESC cis rs1003719 0.788 rs2835574 chr21:38455324 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.67 0.47 4.41e-16 Eye color traits; CESC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg18099408 chr3:52552593 STAB1 -0.34 -5.47 -0.32 1.05e-7 Bipolar disorder; CESC cis rs367615 0.918 rs10054960 chr5:108866448 C/A cg17395555 chr5:108820864 NA 0.55 8.12 0.45 1.81e-14 Colorectal cancer (SNP x SNP interaction); CESC cis rs1707322 0.752 rs28545085 chr1:46201950 G/A cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs933688 1.000 rs10041402 chr5:90738948 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.96 12.8 0.62 1.61e-29 Smoking behavior; CESC trans rs60843830 1.000 rs60484953 chr2:221560 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 8.01 0.44 3.76e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs72781680 0.898 rs17462558 chr2:24020812 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.21e-8 Lymphocyte counts; CESC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.57 0.64 3.24e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.55 -6.19 -0.36 2.29e-9 Multiple sclerosis; CESC cis rs7809950 0.678 rs4730235 chr7:107022506 T/C cg23024343 chr7:107201750 COG5 -0.59 -7.46 -0.42 1.22e-12 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15244168 chr11:65403161 PCNXL3 0.47 6.66 0.38 1.59e-10 Fibrinogen levels; CESC cis rs7107174 1.000 rs11237480 chr11:78110385 C/A cg02023728 chr11:77925099 USP35 0.38 5.54 0.32 7.16e-8 Testicular germ cell tumor; CESC cis rs6674176 1.000 rs11210937 chr1:44405563 T/C cg13606994 chr1:44402422 ARTN -0.38 -5.56 -0.32 6.53e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs3126085 0.825 rs4845428 chr1:152225261 T/C cg03465714 chr1:152285911 FLG -0.44 -5.43 -0.32 1.25e-7 Atopic dermatitis; CESC cis rs922182 0.538 rs16947599 chr15:64260944 C/T cg24729988 chr15:64271149 DAPK2 -0.4 -5.57 -0.32 6.38e-8 Blood protein levels; CESC cis rs7666738 0.830 rs7696715 chr4:98938486 T/C cg03467027 chr4:99064603 C4orf37 0.48 5.91 0.34 1.03e-8 Colonoscopy-negative controls vs population controls; CESC cis rs798554 0.704 rs798513 chr7:2782493 C/T cg09658497 chr7:2847517 GNA12 -0.35 -5.26 -0.31 2.92e-7 Height; CESC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg11247378 chr22:39784982 NA -0.64 -9.68 -0.51 3.5e-19 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg24818145 chr4:99064322 C4orf37 0.39 5.18 0.3 4.43e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6690583 0.623 rs6700723 chr1:85514234 C/T cg22153463 chr1:85462885 MCOLN2 0.74 7.53 0.42 8.03e-13 Serum sulfate level; CESC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg22823121 chr1:150693482 HORMAD1 0.36 5.13 0.3 5.55e-7 Melanoma; CESC cis rs244293 0.730 rs9303362 chr17:53062553 G/A cg19360675 chr17:53046073 COX11;STXBP4 -0.47 -6.15 -0.35 2.8e-9 Menarche (age at onset); CESC cis rs4975616 0.836 rs421629 chr5:1320136 G/A cg07493874 chr5:1342172 CLPTM1L -0.42 -7.83 -0.43 1.15e-13 Lung cancer; CESC cis rs5769707 0.749 rs8137251 chr22:50036669 G/A cg20744362 chr22:50050164 C22orf34 0.43 6.94 0.39 3e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg00701064 chr4:6280414 WFS1 0.67 11.29 0.57 2.09e-24 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6542838 0.704 rs13011428 chr2:99528305 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.4 -5.09 -0.3 6.67e-7 Fear of minor pain; CESC cis rs6942756 1.000 rs10954226 chr7:128953095 T/G cg02491457 chr7:128862824 NA -0.66 -8.93 -0.48 7.56e-17 White matter hyperintensity burden; CESC cis rs2486288 0.656 rs11632777 chr15:45551045 C/T cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg18032046 chr6:28092343 ZSCAN16 -0.47 -6.17 -0.35 2.48e-9 Cardiac Troponin-T levels; CESC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg25067162 chr17:41277974 BRCA1;NBR2 -0.41 -5.55 -0.32 6.82e-8 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10633147 chr2:68384753 WDR92;PNO1 0.56 6.44 0.37 5.75e-10 Gut microbiome composition (summer); CESC cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.78e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg24675658 chr1:53192096 ZYG11B -0.5 -6.19 -0.36 2.22e-9 Monocyte count; CESC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg22823121 chr1:150693482 HORMAD1 0.48 7.09 0.4 1.21e-11 Tonsillectomy; CESC cis rs1707322 0.686 rs2991987 chr1:46081422 C/G cg05343316 chr1:45956843 TESK2 -0.52 -6.39 -0.37 7.26e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05881776 chr2:235860554 SH3BP4 0.53 7.18 0.4 7.01e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2835872 0.733 rs2850124 chr21:39036763 T/A cg06728970 chr21:39037746 KCNJ6 0.3 5.41 0.32 1.44e-7 Electroencephalographic traits in alcoholism; CESC cis rs4965006 0.915 rs7969545 chr12:132419157 C/T cg00588090 chr12:132412438 PUS1 -0.51 -7.23 -0.41 5.14e-12 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs1413885 0.548 rs6588136 chr1:65837119 C/G cg14976592 chr1:65886160 LEPROT;LEPR 0.46 5.94 0.34 9.02e-9 Anticoagulant levels; CESC cis rs10870270 0.956 rs11146325 chr10:133767529 A/G cg26149184 chr10:133730230 NA 0.38 5.17 0.3 4.57e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25743584 chr17:27402893 TIAF1;MYO18A 0.43 6.01 0.35 6.16e-9 Fibrinogen levels; CESC cis rs2952156 0.920 rs14050 chr17:37828072 C/T cg20243544 chr17:37824526 PNMT 0.63 8.05 0.44 2.85e-14 Asthma; CESC cis rs1843834 0.755 rs10192196 chr2:225577135 C/T cg22455342 chr2:225449267 CUL3 0.42 5.5 0.32 8.87e-8 IgE levels in asthmatics (D.p. specific); CESC cis rs400736 0.702 rs225134 chr1:8098730 A/G cg25007680 chr1:8021821 PARK7 0.71 9.97 0.52 4.51e-20 Response to antidepressants and depression; CESC cis rs60154123 0.772 rs815358 chr1:210430437 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.48 5.09 0.3 6.91e-7 Coronary artery disease; CESC cis rs2249625 0.545 rs2463746 chr6:72876954 C/G cg18830697 chr6:72922368 RIMS1 -0.49 -7.25 -0.41 4.49e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs11031096 0.711 rs4910890 chr11:4153407 C/T cg18678763 chr11:4115507 RRM1 -0.46 -6.31 -0.36 1.19e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs9581857 0.579 rs1759861 chr13:27996406 A/C cg22138327 chr13:27999177 GTF3A -0.61 -5.11 -0.3 6.07e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs858239 0.539 rs28624974 chr7:23188936 T/C cg23682824 chr7:23144976 KLHL7 0.51 6.83 0.39 5.81e-11 Cerebrospinal fluid biomarker levels; CESC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.66 0.47 4.81e-16 Intelligence (multi-trait analysis); CESC trans rs61931739 1.000 rs12304768 chr12:34000986 T/G cg26384229 chr12:38710491 ALG10B -0.45 -6.25 -0.36 1.63e-9 Morning vs. evening chronotype; CESC cis rs78456975 1.000 rs6744743 chr2:1558161 C/T cg26248373 chr2:1572462 NA 0.57 5.45 0.32 1.14e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg11764359 chr7:65958608 NA -0.79 -9.51 -0.5 1.18e-18 Aortic root size; CESC trans rs3780486 0.505 rs1411609 chr9:33137303 C/T cg20290983 chr6:43655470 MRPS18A 0.75 11.77 0.59 5.18e-26 IgG glycosylation; CESC cis rs2040771 0.745 rs2283646 chr22:19273902 A/G cg17887427 chr22:19166691 SLC25A1 0.4 5.15 0.3 5e-7 Metabolite levels (small molecules and protein measures); CESC cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.29 0.31 2.52e-7 Personality dimensions; CESC cis rs9811920 0.535 rs793483 chr3:99489825 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.34 -5.44 -0.32 1.19e-7 Axial length; CESC cis rs4862750 0.872 rs13101380 chr4:187894744 G/A cg22105103 chr4:187893119 NA 0.45 6.6 0.38 2.25e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg12648201 chr2:27665141 KRTCAP3 -0.39 -7.12 -0.4 1.01e-11 Total body bone mineral density; CESC cis rs6430585 0.527 rs76622824 chr2:136411879 A/G cg07169764 chr2:136633963 MCM6 1.06 12.14 0.6 2.95e-27 Corneal structure; CESC trans rs8073060 0.660 rs58266733 chr17:34003812 A/T cg19694781 chr19:47549865 TMEM160 -0.71 -6.74 -0.38 9.95e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg07167872 chr1:205819463 PM20D1 -0.63 -10.57 -0.54 5.2e-22 Monocyte percentage of white cells; CESC cis rs56046484 0.913 rs12906544 chr15:85576063 G/A cg08123816 chr15:85640762 PDE8A -0.49 -6.25 -0.36 1.63e-9 Testicular germ cell tumor; CESC cis rs9682041 0.866 rs6444926 chr3:170133235 T/C cg11886554 chr3:170076028 SKIL 0.92 7.8 0.43 1.43e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC cis rs6474412 0.957 rs6474414 chr8:42560336 A/C cg25026480 chr8:42547641 NA 0.32 5.09 0.3 6.85e-7 Smoking behavior; CESC cis rs11122272 0.735 rs2474623 chr1:231513993 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs4911259 0.552 rs6057663 chr20:31463071 G/T cg13636640 chr20:31349939 DNMT3B -0.53 -7.41 -0.41 1.66e-12 Inflammatory bowel disease; CESC cis rs9300255 0.568 rs1621194 chr12:123651018 T/C cg19016782 chr12:123741754 C12orf65 -0.4 -5.77 -0.33 2.27e-8 Neutrophil percentage of white cells; CESC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.26 -0.49 7.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4722585 0.533 rs757371 chr7:26199207 A/G cg07876897 chr7:26191696 NFE2L3 0.44 5.68 0.33 3.46e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); CESC cis rs7084402 0.967 rs1658462 chr10:60298284 A/C cg07615347 chr10:60278583 BICC1 0.6 9.46 0.5 1.77e-18 Refractive error; CESC cis rs9522267 0.535 rs56330641 chr13:112233538 C/T cg10483660 chr13:112241077 NA -0.33 -5.79 -0.33 2.04e-8 Hepatitis; CESC trans rs1003719 0.715 rs762139 chr21:38568475 A/T cg26370409 chr1:10002828 NMNAT1;LZIC -0.43 -6.01 -0.35 6.25e-9 Eye color traits; CESC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg04267008 chr7:1944627 MAD1L1 -0.63 -7.63 -0.42 4.15e-13 Bipolar disorder and schizophrenia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg14771734 chr5:79703670 ZFYVE16 -0.48 -6.24 -0.36 1.76e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7605827 0.897 rs4668899 chr2:15511575 C/A cg19274914 chr2:15703543 NA 0.32 5.58 0.32 5.99e-8 Educational attainment (years of education); CESC cis rs9487051 0.621 rs566164 chr6:109506461 C/T cg01475377 chr6:109611718 NA -0.39 -5.13 -0.3 5.65e-7 Reticulocyte fraction of red cells; CESC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg23281280 chr6:28129359 ZNF389 0.57 7.78 0.43 1.61e-13 Depression; CESC cis rs7818345 1.000 rs11991105 chr8:19290655 C/T cg11303988 chr8:19266685 CSGALNACT1 0.33 5.88 0.34 1.24e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs7212590 0.748 rs7220187 chr17:57897609 C/T cg20303301 chr17:57937339 TUBD1 -0.59 -5.57 -0.32 6.14e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs2777491 0.957 rs8026197 chr15:41711447 C/T cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.86 -0.52 9.78e-20 Ulcerative colitis; CESC trans rs8073060 0.586 rs225250 chr17:33941963 A/G cg19694781 chr19:47549865 TMEM160 -0.71 -6.99 -0.39 2.2e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs2296225 0.722 rs58464781 chr1:21051430 C/A cg24673385 chr1:21051448 SH2D5 0.33 5.37 0.31 1.74e-7 Eosinophilic esophagitis; CESC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg03188948 chr7:1209495 NA 0.72 6.91 0.39 3.61e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3749237 0.964 rs1799845 chr3:49847623 A/G cg03060546 chr3:49711283 APEH 0.68 8.16 0.45 1.4e-14 Resting heart rate; CESC cis rs73194058 1 rs73194058 chr21:34764288 C/A cg14850771 chr21:34775459 IFNGR2 0.79 7.98 0.44 4.39e-14 Rheumatoid arthritis; CESC cis rs12477438 0.765 rs10181344 chr2:99692829 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs854765 0.927 rs4925138 chr17:17992793 T/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.44 -5.81 -0.34 1.79e-8 Total body bone mineral density; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg11827907 chr15:83654871 FAM103A1 -0.47 -6.02 -0.35 5.65e-9 Ulcerative colitis; CESC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg06877462 chr1:205807181 PM20D1 0.47 7.08 0.4 1.28e-11 Menarche (age at onset); CESC cis rs2635047 0.811 rs12956009 chr18:44768024 T/C cg24371990 chr18:44770781 NA 0.43 6.95 0.39 2.92e-11 Educational attainment; CESC cis rs7944584 0.632 rs7116451 chr11:47322327 G/A cg20307385 chr11:47447363 PSMC3 0.61 7.54 0.42 7.28e-13 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC trans rs9858542 0.953 rs11711485 chr3:49491983 G/T cg21659725 chr3:3221576 CRBN -0.55 -6.55 -0.37 2.95e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2073499 0.935 rs3755832 chr3:50305234 G/A cg05260129 chr3:50388622 TUSC4;CYB561D2 0.74 6.11 0.35 3.63e-9 Schizophrenia; CESC cis rs3806843 0.900 rs2261651 chr5:140136804 A/C cg26395211 chr5:140044315 WDR55 0.43 5.46 0.32 1.07e-7 Depressive symptoms (multi-trait analysis); CESC trans rs12310956 0.532 rs1525904 chr12:33962448 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.35 0.46 3.79e-15 Morning vs. evening chronotype; CESC cis rs1451375 0.550 rs10239830 chr7:50603829 A/G cg14593290 chr7:50529359 DDC 0.5 6.05 0.35 5.03e-9 Malaria; CESC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg09359103 chr1:154839909 KCNN3 -0.68 -12.71 -0.62 3.15e-29 Prostate cancer; CESC cis rs10823500 0.777 rs10999196 chr10:71982305 T/C cg04118878 chr10:71993077 PPA1 0.47 5.56 0.32 6.61e-8 Blood protein levels; CESC cis rs1003719 0.591 rs1053966 chr21:38568009 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.5 -6.28 -0.36 1.35e-9 Eye color traits; CESC cis rs2075371 0.932 rs34664116 chr7:133984878 G/A cg11752832 chr7:134001865 SLC35B4 0.53 6.92 0.39 3.47e-11 Mean platelet volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11810498 chr9:130477698 PTRH1;TTC16 -0.45 -6.26 -0.36 1.52e-9 Gambling; CESC cis rs3768617 0.528 rs4651144 chr1:183097421 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.27 0.66 1.13e-34 Fuchs's corneal dystrophy; CESC cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg20573242 chr4:122745356 CCNA2 0.62 7.47 0.42 1.2e-12 Type 2 diabetes; CESC cis rs4964805 0.657 rs73192049 chr12:104187993 T/C cg02344784 chr12:104178138 NT5DC3 0.46 6.57 0.37 2.73e-10 Attention deficit hyperactivity disorder; CESC cis rs1881797 0.872 rs2141544 chr1:247690800 A/G cg18198730 chr1:247681584 NA 0.58 8.78 0.47 2.01e-16 Acute lymphoblastic leukemia (childhood); CESC cis rs5769765 0.913 rs28670284 chr22:50221973 C/T cg02269571 chr22:50332266 NA -0.62 -6.95 -0.39 2.88e-11 Schizophrenia; CESC cis rs2070488 1.000 rs2268757 chr3:38505853 C/T cg24069376 chr3:38537580 EXOG 0.45 8.22 0.45 9.37e-15 Electrocardiographic conduction measures; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14032528 chr1:11866380 CLCN6;MTHFR -0.55 -6.12 -0.35 3.38e-9 Gut microbiome composition (summer); CESC trans rs61931739 0.614 rs6488172 chr12:33745669 A/G cg26384229 chr12:38710491 ALG10B 0.43 6.31 0.36 1.18e-9 Morning vs. evening chronotype; CESC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg00339695 chr16:24857497 SLC5A11 0.5 6.57 0.37 2.58e-10 Intelligence (multi-trait analysis); CESC cis rs7555523 0.832 rs7524755 chr1:165694897 A/G cg24409356 chr1:165738333 TMCO1 0.69 6.52 0.37 3.46e-10 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg27266027 chr21:40555129 PSMG1 0.45 5.46 0.32 1.11e-7 Cognitive function; CESC cis rs2228479 0.850 rs62056069 chr16:89912000 C/T cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC cis rs4604732 0.536 rs61184655 chr1:247651342 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.39 5.07 0.3 7.62e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs941873 0.900 rs7092536 chr10:81131332 A/C cg11057378 chr10:81107060 PPIF 0.32 5.15 0.3 5.15e-7 Height; CESC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg07153921 chr17:41440717 NA -0.38 -5.04 -0.3 8.65e-7 Menopause (age at onset); CESC cis rs2249625 0.761 rs2496500 chr6:72884438 G/C cg18830697 chr6:72922368 RIMS1 -0.39 -5.5 -0.32 8.88e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs2274273 0.840 rs2009291 chr14:55838230 A/C cg04306507 chr14:55594613 LGALS3 -0.32 -6.34 -0.36 9.91e-10 Protein biomarker; CESC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.56 -0.37 2.75e-10 Bipolar disorder; CESC cis rs4253772 0.591 rs6008546 chr22:46686377 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 6.94 0.39 2.93e-11 LDL cholesterol;Cholesterol, total; CESC cis rs79839061 0.656 rs11726508 chr4:888937 C/T cg07828340 chr4:882639 GAK 0.82 7.08 0.4 1.31e-11 Intelligence (multi-trait analysis); CESC cis rs2228479 0.850 rs12597296 chr16:89822331 C/T cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC trans rs2727020 0.521 rs1909220 chr11:49572109 T/C cg15704280 chr7:45808275 SEPT13 -0.86 -10.72 -0.55 1.6e-22 Coronary artery disease; CESC cis rs2070433 0.528 rs68063691 chr21:47759237 T/C cg12379764 chr21:47803548 PCNT 0.67 7.39 0.41 1.93e-12 Lymphocyte counts; CESC cis rs5750830 0.645 rs4821890 chr22:39777523 G/A cg02038168 chr22:39784481 NA -0.56 -7.63 -0.42 4.28e-13 Intelligence (multi-trait analysis); CESC cis rs7520050 0.931 rs11211224 chr1:46384388 G/A cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.67e-9 Red blood cell count;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19403339 chr2:183580841 DNAJC10 0.55 6.13 0.35 3.25e-9 Gut microbiome composition (summer); CESC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg24675658 chr1:53192096 ZYG11B 0.64 7.98 0.44 4.39e-14 Monocyte count; CESC cis rs3796352 1.000 rs2564926 chr3:53094730 G/A cg07884673 chr3:53033167 SFMBT1 -0.65 -6.01 -0.35 6.06e-9 Immune reponse to smallpox (secreted IL-2); CESC cis rs6088580 0.584 rs2378203 chr20:32993846 A/T cg06115741 chr20:33292138 TP53INP2 -0.49 -6.32 -0.36 1.13e-9 Glomerular filtration rate (creatinine); CESC trans rs7824557 0.527 rs2572447 chr8:11239510 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -6.15 -0.35 2.88e-9 Retinal vascular caliber; CESC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg04772025 chr11:68637568 NA 0.53 6.49 0.37 4.12e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9359856 0.564 rs10484885 chr6:90395016 A/G cg13799429 chr6:90582589 CASP8AP2 -0.65 -5.99 -0.35 6.91e-9 Bipolar disorder; CESC cis rs863345 0.584 rs6672789 chr1:158497139 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -6.95 -0.39 2.8e-11 Pneumococcal bacteremia; CESC cis rs9486715 0.867 rs2475025 chr6:96988696 A/T cg06623918 chr6:96969491 KIAA0776 -0.96 -15.2 -0.68 5.77e-38 Headache; CESC cis rs9902453 0.726 rs3115088 chr17:28031275 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.77 10.47 0.54 1.11e-21 Coffee consumption (cups per day); CESC cis rs9435341 1.000 rs9435341 chr1:107616641 T/C cg09367891 chr1:107599246 PRMT6 -0.53 -6.76 -0.38 8.94e-11 Facial morphology (factor 21, depth of nasal alae); CESC cis rs7107174 1.000 rs1567890 chr11:78101700 T/C cg02023728 chr11:77925099 USP35 0.47 6.28 0.36 1.37e-9 Testicular germ cell tumor; CESC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg27535305 chr1:53392650 SCP2 -0.33 -5.42 -0.32 1.31e-7 Monocyte count; CESC cis rs7546094 1.000 rs7544663 chr1:113089006 A/G cg22162597 chr1:113214053 CAPZA1 -0.36 -5.53 -0.32 7.79e-8 Platelet distribution width; CESC cis rs2191566 0.576 rs381888 chr19:44493005 C/T cg20607764 chr19:44506953 ZNF230 0.44 5.58 0.32 5.9e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs854765 0.964 rs72827413 chr17:17988299 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.45 -5.63 -0.33 4.56e-8 Total body bone mineral density; CESC cis rs2014572 0.967 rs10426174 chr19:57756055 G/A cg12963866 chr19:57752005 ZNF805 -0.49 -6.49 -0.37 4.09e-10 Hyperactive-impulsive symptoms; CESC cis rs7927592 0.913 rs55883802 chr11:68278829 G/A cg20283391 chr11:68216788 NA -0.63 -7.61 -0.42 4.78e-13 Total body bone mineral density; CESC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg17372223 chr3:52568218 NT5DC2 0.43 6.65 0.38 1.62e-10 Bipolar disorder; CESC trans rs11098499 0.909 rs11723757 chr4:120299669 C/T cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs8050907 0.744 rs9922933 chr16:4572602 T/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.72 5.17 0.3 4.53e-7 Obesity-related traits; CESC cis rs9915657 0.933 rs8075603 chr17:70136833 G/T cg06234051 chr17:70120541 SOX9 -0.34 -5.04 -0.3 8.63e-7 Thyroid hormone levels; CESC cis rs763121 0.853 rs5750630 chr22:38985818 A/C cg06022373 chr22:39101656 GTPBP1 0.83 12.0 0.59 8.7e-27 Menopause (age at onset); CESC cis rs61931739 0.500 rs35030191 chr12:34548865 C/T cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs2842992 0.714 rs2495278 chr6:160123674 G/A cg11366901 chr6:160182831 ACAT2 0.83 10.58 0.54 4.83e-22 Age-related macular degeneration (geographic atrophy); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg20228115 chr3:167813730 GOLIM4 0.39 6.0 0.35 6.53e-9 Vertical cup-disc ratio; CESC trans rs1945213 0.659 rs2086558 chr11:55844453 T/G cg03929089 chr4:120376271 NA 0.76 7.26 0.41 4.31e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs595982 0.546 rs12461075 chr19:49399821 G/A cg21252483 chr19:49399788 TULP2 -0.39 -5.55 -0.32 6.87e-8 Red cell distribution width; CESC cis rs12042052 1.000 rs12042052 chr1:232935719 C/T cg00951395 chr1:232941775 KIAA1383 -0.8 -6.78 -0.38 7.61e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs2228479 0.850 rs17227057 chr16:89816333 C/T cg04013166 chr16:89971882 TCF25 0.77 6.66 0.38 1.58e-10 Skin colour saturation; CESC cis rs4474465 0.646 rs10793337 chr11:78285875 A/T cg27205649 chr11:78285834 NARS2 0.53 7.05 0.4 1.54e-11 Alzheimer's disease (survival time); CESC cis rs244293 0.760 rs1990673 chr17:53050025 C/T cg19360675 chr17:53046073 COX11;STXBP4 -0.47 -6.16 -0.35 2.72e-9 Menarche (age at onset); CESC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg02931644 chr1:25747376 RHCE 0.4 6.64 0.38 1.75e-10 Erythrocyte sedimentation rate; CESC cis rs9987353 0.519 rs13276350 chr8:9063157 T/C cg06636001 chr8:8085503 FLJ10661 -0.55 -6.54 -0.37 3.1e-10 Recombination measurement; CESC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg03188948 chr7:1209495 NA 0.54 5.53 0.32 7.66e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs5760092 0.618 rs4461358 chr22:24260106 T/C cg18538332 chr22:24372958 LOC391322 0.72 9.34 0.5 4.15e-18 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.82 8.13 0.45 1.7e-14 Platelet count; CESC cis rs7927592 0.956 rs7126340 chr11:68257293 C/T cg16797656 chr11:68205561 LRP5 0.39 5.51 0.32 8.45e-8 Total body bone mineral density; CESC cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.4 0.31 1.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs796364 1.000 rs11680723 chr2:200810957 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.88 -6.62 -0.38 1.97e-10 Schizophrenia; CESC cis rs2688608 0.587 rs2894040 chr10:75478159 A/C cg23231163 chr10:75533350 FUT11 -0.34 -5.28 -0.31 2.75e-7 Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14993530 chr1:245027115 HNRNPU 0.52 6.02 0.35 5.75e-9 Gut microbiome composition (summer); CESC cis rs12410462 1.000 rs12407171 chr1:227642282 G/A cg23173402 chr1:227635558 NA 0.56 5.57 0.32 6.19e-8 Major depressive disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19827167 chr1:94312206 MIR760 -0.45 -6.27 -0.36 1.45e-9 Asthma; CESC cis rs9911578 0.967 rs11079368 chr17:57086473 C/T cg05425664 chr17:57184151 TRIM37 0.53 7.37 0.41 2.16e-12 Intelligence (multi-trait analysis); CESC cis rs5769765 0.773 rs6520065 chr22:50294470 A/T cg02269571 chr22:50332266 NA -0.45 -6.03 -0.35 5.63e-9 Schizophrenia; CESC cis rs62229266 0.771 rs11701590 chr21:37384730 A/C cg12218747 chr21:37451666 NA -0.38 -5.36 -0.31 1.83e-7 Mitral valve prolapse; CESC cis rs2439831 1.000 rs690436 chr15:43761205 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.56 0.54 5.46e-22 Lung cancer in ever smokers; CESC cis rs12497850 0.829 rs8926 chr3:49052785 T/A cg06212747 chr3:49208901 KLHDC8B 0.7 9.34 0.5 4.23e-18 Parkinson's disease; CESC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg25767906 chr1:53392781 SCP2 -0.44 -5.51 -0.32 8.62e-8 Monocyte count; CESC cis rs2180341 1.000 rs6569480 chr6:127621748 A/G cg24812749 chr6:127587940 RNF146 1.0 14.92 0.68 6.1e-37 Breast cancer; CESC cis rs227584 0.663 rs2040810 chr17:42243771 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.55 -7.33 -0.41 2.73e-12 Bone mineral density (hip);Bone mineral density; CESC cis rs752010 0.967 rs4083593 chr1:42099583 A/G cg06885757 chr1:42089581 HIVEP3 0.5 8.06 0.44 2.56e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs6141600 0.506 rs2590990 chr20:34671179 A/G cg07747181 chr20:34652970 NA -0.37 -5.12 -0.3 5.79e-7 Height;Hip circumference; CESC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg22823121 chr1:150693482 HORMAD1 0.48 7.1 0.4 1.14e-11 Tonsillectomy; CESC cis rs9811920 0.625 rs9290003 chr3:99906993 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.38 5.87 0.34 1.28e-8 Axial length; CESC cis rs4268898 0.722 rs11680491 chr2:24416292 T/A cg06627628 chr2:24431161 ITSN2 0.59 7.74 0.43 2.05e-13 Asthma; CESC cis rs4561483 0.545 rs9927446 chr16:11957164 A/T cg08843971 chr16:11963173 GSPT1 0.46 6.42 0.37 6.41e-10 Testicular germ cell tumor; CESC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg06873352 chr17:61820015 STRADA 0.73 12.96 0.62 4.25e-30 Prudent dietary pattern; CESC cis rs1322639 0.614 rs7751131 chr6:169578710 G/A cg03254818 chr6:169586852 NA 0.55 5.95 0.34 8.28e-9 Pulse pressure; CESC cis rs6695640 0.854 rs2762890 chr1:17736578 A/G cg01904812 chr1:17746340 RCC2 0.37 5.2 0.3 3.98e-7 Mean platelet volume; CESC cis rs9287719 0.745 rs4997809 chr2:10755542 G/A cg02196655 chr2:10830764 NOL10 -0.37 -5.51 -0.32 8.5e-8 Prostate cancer; CESC cis rs2011503 1.000 rs8101219 chr19:19643715 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.09 0.3 6.68e-7 Bipolar disorder; CESC cis rs3096299 0.967 rs753852 chr16:89446419 G/A cg08822215 chr16:89438651 ANKRD11 -0.42 -6.35 -0.36 9.47e-10 Multiple myeloma (IgH translocation); CESC cis rs2073300 0.609 rs6137910 chr20:23346515 C/G cg16736954 chr20:23401023 NAPB 0.77 5.74 0.33 2.6e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg10494973 chr17:80897199 TBCD 0.5 5.69 0.33 3.34e-8 Breast cancer; CESC trans rs35883536 1.000 rs9803842 chr1:101134877 G/T cg16931499 chr17:42786676 DBF4B 0.42 6.14 0.35 3.01e-9 Monocyte count; CESC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg01097406 chr16:89675127 NA -0.33 -5.05 -0.3 8.41e-7 Vitiligo; CESC cis rs6964587 0.692 rs4727268 chr7:91840724 T/C cg17063962 chr7:91808500 NA 0.46 6.56 0.37 2.8e-10 Breast cancer; CESC cis rs72945132 0.882 rs66989619 chr11:70202127 G/C cg00319359 chr11:70116639 PPFIA1 0.73 6.96 0.39 2.63e-11 Coronary artery disease; CESC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg25767906 chr1:53392781 SCP2 -0.48 -6.4 -0.37 6.99e-10 Monocyte count; CESC cis rs9399135 0.935 rs11760000 chr6:135370496 G/A cg24558204 chr6:135376177 HBS1L 0.51 6.94 0.39 3.01e-11 Red blood cell count; CESC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg17372223 chr3:52568218 NT5DC2 0.44 6.57 0.37 2.6e-10 Bipolar disorder; CESC cis rs7666738 0.578 rs1989109 chr4:98881246 T/A cg17366294 chr4:99064904 C4orf37 0.56 7.87 0.44 9.05e-14 Colonoscopy-negative controls vs population controls; CESC cis rs1904096 0.506 rs13435702 chr4:95167751 G/A cg11021082 chr4:95130006 SMARCAD1 -0.63 -10.06 -0.53 2.2e-20 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12311644 chr22:31687046 PIK3IP1 0.49 6.2 0.36 2.2e-9 Gut microbiota (bacterial taxa); CESC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.65 0.64 1.8e-32 Prudent dietary pattern; CESC cis rs7192380 0.639 rs12448486 chr16:69802878 G/A cg15192750 chr16:69999425 NA -0.37 -5.12 -0.3 5.99e-7 Sjögren's syndrome; CESC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg08968635 chr6:28129556 ZNF389 0.42 5.72 0.33 2.82e-8 Depression; CESC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 11.2 0.57 4.36e-24 Platelet count; CESC cis rs4595586 0.545 rs1375796 chr12:39410592 G/T cg13010199 chr12:38710504 ALG10B 0.44 5.57 0.32 6.35e-8 Morning vs. evening chronotype; CESC cis rs1559088 0.522 rs7254912 chr19:33554151 A/G cg27124370 chr19:33622961 WDR88 0.54 7.46 0.42 1.23e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg06456125 chr7:65229604 NA -0.4 -5.16 -0.3 4.83e-7 Aortic root size; CESC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg15445000 chr17:37608096 MED1 0.38 6.39 0.37 7.3e-10 Glomerular filtration rate (creatinine); CESC cis rs10129255 0.500 rs6576230 chr14:107186778 C/A cg23076370 chr14:107095027 NA -0.66 -10.03 -0.52 2.9e-20 Kawasaki disease; CESC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg04369109 chr6:150039330 LATS1 -0.43 -5.83 -0.34 1.6e-8 Lung cancer; CESC cis rs6598955 0.724 rs12757113 chr1:26597144 C/T cg04990556 chr1:26633338 UBXN11 -0.8 -11.67 -0.58 1.15e-25 Obesity-related traits; CESC cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.84 13.61 0.64 2.42e-32 Hip circumference adjusted for BMI; CESC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg21724239 chr8:58056113 NA 0.6 5.45 0.32 1.17e-7 Developmental language disorder (linguistic errors); CESC cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg10556349 chr10:835070 NA 0.57 5.55 0.32 6.8e-8 Eosinophil percentage of granulocytes; CESC cis rs2439831 0.681 rs511673 chr15:43618863 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.71 0.55 1.74e-22 Lung cancer in ever smokers; CESC cis rs9815354 1.000 rs2625667 chr3:41900951 C/A cg03022575 chr3:42003672 ULK4 0.45 5.23 0.31 3.48e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.89 0.44 7.83e-14 Prudent dietary pattern; CESC cis rs8062405 0.755 rs56209193 chr16:28585636 C/T cg07382826 chr16:28625726 SULT1A1 0.4 6.52 0.37 3.46e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1707322 0.682 rs3014241 chr1:46087879 A/G cg05343316 chr1:45956843 TESK2 -0.54 -6.65 -0.38 1.68e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs61931739 0.578 rs12582423 chr12:33596502 G/C cg26384229 chr12:38710491 ALG10B -0.44 -6.32 -0.36 1.1e-9 Morning vs. evening chronotype; CESC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg26939375 chr7:64535504 NA 0.66 8.81 0.48 1.64e-16 Calcium levels; CESC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg22800045 chr5:56110881 MAP3K1 0.83 9.98 0.52 3.92e-20 Initial pursuit acceleration; CESC cis rs7116495 1.000 rs1573502 chr11:71747428 C/T cg10381502 chr11:71823885 C11orf51 -0.68 -5.65 -0.33 4.05e-8 Severe influenza A (H1N1) infection; CESC cis rs7208859 0.623 rs216439 chr17:28927884 T/C cg13385521 chr17:29058706 SUZ12P 0.77 5.67 0.33 3.8e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg24881330 chr22:46731750 TRMU 0.86 7.93 0.44 6.15e-14 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg24399712 chr22:39784796 NA -0.81 -10.81 -0.55 8.51e-23 Intelligence (multi-trait analysis); CESC trans rs17536732 0.786 rs114318946 chr4:162848455 A/G cg12177677 chr2:158300475 CYTIP -0.64 -6.25 -0.36 1.66e-9 Risky sexual behaviors (alcohol dependence interaction); CESC cis rs1023500 0.551 rs133379 chr22:42468535 A/G cg15557168 chr22:42548783 NA -0.39 -5.32 -0.31 2.19e-7 Schizophrenia; CESC cis rs2228479 0.867 rs11642451 chr16:89958127 T/C cg14709524 chr16:89940631 TCF25 0.73 5.64 0.33 4.36e-8 Skin colour saturation; CESC cis rs7712401 0.601 rs154500 chr5:122211991 T/G cg19412675 chr5:122181750 SNX24 0.41 5.15 0.3 5.07e-7 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg11989942 chr17:80067146 CCDC57 0.44 6.15 0.35 2.89e-9 Fibrinogen levels; CESC cis rs911555 0.617 rs7156036 chr14:103908142 A/G cg12935359 chr14:103987150 CKB 0.65 9.56 0.51 8.31e-19 Intelligence (multi-trait analysis); CESC cis rs240764 0.635 rs6901854 chr6:100932291 C/T cg21058520 chr6:100914733 NA 0.4 6.07 0.35 4.31e-9 Neuroticism; CESC cis rs7666738 0.830 rs7672901 chr4:98938781 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.48 0.61 1.93e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4132509 0.649 rs12038981 chr1:243866855 G/A cg21452805 chr1:244014465 NA 0.48 5.13 0.3 5.55e-7 RR interval (heart rate); CESC cis rs9916302 0.904 rs4795359 chr17:37573146 C/T cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 4.03e-10 Glomerular filtration rate (creatinine); CESC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg04166393 chr7:2884313 GNA12 0.65 8.26 0.45 7.21e-15 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24764865 chr14:36295508 BRMS1L 0.55 6.06 0.35 4.74e-9 Gut microbiome composition (summer); CESC cis rs16866061 0.962 rs16866045 chr2:225413020 G/A cg12698349 chr2:225449008 CUL3 0.75 11.56 0.58 2.78e-25 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23748172 chr11:66633713 PC 0.46 6.87 0.39 4.64e-11 Fibrinogen levels; CESC cis rs1008375 0.835 rs9760627 chr4:17651508 C/T cg02297831 chr4:17616191 MED28 0.61 7.68 0.43 3.1400000000000003e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg00166722 chr3:10149974 C3orf24 0.48 5.92 0.34 9.76e-9 Alzheimer's disease; CESC trans rs61931739 0.534 rs11052979 chr12:34035774 G/T cg26384229 chr12:38710491 ALG10B 0.59 8.27 0.45 6.35e-15 Morning vs. evening chronotype; CESC cis rs9796 0.717 rs2947494 chr15:41375741 C/T cg12426344 chr15:41135900 SPINT1 -0.23 -5.1 -0.3 6.45e-7 Menopause (age at onset); CESC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg03806693 chr22:41940476 POLR3H -1.16 -13.46 -0.64 7.72e-32 Vitiligo; CESC cis rs4595586 0.525 rs11609150 chr12:39408622 A/C cg26384229 chr12:38710491 ALG10B 0.62 8.72 0.47 3.18e-16 Morning vs. evening chronotype; CESC cis rs589691 0.502 rs487662 chr11:64481880 G/A cg07220939 chr11:64358617 SLC22A12 -0.35 -5.11 -0.3 6.17e-7 Urate levels; CESC cis rs72634258 0.945 rs4908724 chr1:8119251 G/T cg00042356 chr1:8021962 PARK7 0.8 7.14 0.4 9.2e-12 Inflammatory bowel disease; CESC cis rs11552708 0.504 rs9890935 chr17:7391282 A/G cg02795151 chr17:7402630 POLR2A 0.55 5.88 0.34 1.26e-8 IgM levels; CESC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg19592336 chr6:28129416 ZNF389 0.47 6.32 0.36 1.09e-9 Parkinson's disease; CESC cis rs7193541 0.965 rs8050262 chr16:74661159 T/C cg01733217 chr16:74700730 RFWD3 0.92 13.55 0.64 4.03e-32 Multiple myeloma; CESC cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg04455712 chr21:45112962 RRP1B 0.42 6.04 0.35 5.25e-9 Mean corpuscular volume; CESC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg04414720 chr1:150670196 GOLPH3L 0.57 8.01 0.44 3.64e-14 Tonsillectomy; CESC cis rs2273669 0.667 rs77002235 chr6:109321497 G/A cg05315195 chr6:109294784 ARMC2 -0.66 -6.01 -0.35 6.04e-9 Prostate cancer; CESC cis rs3793683 0.928 rs10781585 chr10:134553369 C/A cg26818010 chr10:134567672 INPP5A 0.48 6.05 0.35 4.82e-9 Migraine; CESC cis rs1008375 0.898 rs9998130 chr4:17593905 A/G cg16339924 chr4:17578868 LAP3 0.85 10.69 0.55 2e-22 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg22029157 chr1:209979665 IRF6 0.48 7.62 0.42 4.64e-13 Monobrow; CESC cis rs1620921 0.505 rs1991598 chr6:161204488 G/A cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs1062177 0.756 rs2964592 chr5:151115688 A/G cg12924095 chr5:151150029 G3BP1 -0.42 -5.48 -0.32 1.01e-7 Preschool internalizing problems; CESC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg24578937 chr1:2090814 PRKCZ 0.38 6.62 0.38 2.03e-10 Height; CESC cis rs6570726 0.846 rs9376954 chr6:145943737 T/A cg23711669 chr6:146136114 FBXO30 0.87 12.7 0.61 3.59e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs4563143 0.514 rs73029081 chr19:29295583 C/G cg04546413 chr19:29218101 NA 0.49 6.05 0.35 4.79e-9 Methadone dose in opioid dependence; CESC cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg11366901 chr6:160182831 ACAT2 0.83 10.52 0.54 7.54e-22 Age-related macular degeneration (geographic atrophy); CESC cis rs17401966 1.000 rs7520935 chr1:10354271 G/T cg15208524 chr1:10270712 KIF1B 0.49 6.26 0.36 1.53e-9 Hepatocellular carcinoma; CESC cis rs5498 0.869 rs2569702 chr19:10403947 A/G cg22910295 chr19:10403862 ICAM5 0.43 6.06 0.35 4.61e-9 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs1055129 0.655 rs3744006 chr17:73838816 G/A cg08125733 chr17:73851984 WBP2 0.55 7.46 0.42 1.23e-12 White matter hyperintensity burden; CESC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg19774624 chr17:42201019 HDAC5 -0.69 -10.03 -0.52 2.7e-20 Total body bone mineral density; CESC cis rs11122272 0.735 rs2247124 chr1:231493687 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -7.9 -0.44 7.28e-14 Hemoglobin concentration; CESC cis rs2070488 0.804 rs13059256 chr3:38504315 T/C cg24069376 chr3:38537580 EXOG 0.33 5.56 0.32 6.63e-8 Electrocardiographic conduction measures; CESC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg18876405 chr7:65276391 NA -0.53 -7.38 -0.41 2.09e-12 Aortic root size; CESC cis rs950169 1.000 rs11638297 chr15:84782417 A/C cg17507749 chr15:85114479 UBE2QP1 0.59 6.6 0.38 2.18e-10 Schizophrenia; CESC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg08968635 chr6:28129556 ZNF389 0.4 5.36 0.31 1.84e-7 Depression; CESC cis rs34734847 0.750 rs708783 chr12:121173932 A/G cg21892295 chr12:121157589 UNC119B -0.34 -5.3 -0.31 2.43e-7 Mean corpuscular volume; CESC cis rs654950 0.806 rs941971 chr1:42040893 T/C cg06885757 chr1:42089581 HIVEP3 -0.63 -10.16 -0.53 1.05e-20 Airway imaging phenotypes; CESC cis rs7246657 0.943 rs2891699 chr19:37920237 A/G cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.69e-9 Coronary artery calcification; CESC cis rs7843479 1.000 rs7821592 chr8:21811530 C/G cg17168535 chr8:21777572 XPO7 0.47 6.34 0.36 9.91e-10 Mean corpuscular volume; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg19183748 chr11:64863586 C11orf2 -0.45 -6.11 -0.35 3.64e-9 Recombination measurement; CESC cis rs4472734 1.000 rs12751657 chr1:214607849 G/A cg00063699 chr1:214624242 PTPN14 -0.34 -5.42 -0.32 1.32e-7 Height; CESC cis rs4728302 0.869 rs2042455 chr7:133580545 A/G cg10665199 chr7:133106180 EXOC4 0.4 5.47 0.32 1.03e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs1008375 0.966 rs10006317 chr4:17702525 A/G cg02297831 chr4:17616191 MED28 0.48 5.76 0.33 2.36e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12410462 0.681 rs76705164 chr1:227615570 G/A cg23173402 chr1:227635558 NA 0.72 6.71 0.38 1.19e-10 Major depressive disorder; CESC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg08499158 chr17:42289980 UBTF -0.45 -5.49 -0.32 9.5e-8 Total body bone mineral density; CESC trans rs78049276 0.688 rs17612693 chr4:148365339 T/A cg13149281 chr14:23389818 RBM23;PRMT5 -0.6 -6.32 -0.36 1.13e-9 Pulse pressure; CESC cis rs2273669 0.667 rs12200531 chr6:109320441 T/C cg05315195 chr6:109294784 ARMC2 -0.66 -6.37 -0.36 8.17e-10 Prostate cancer; CESC cis rs6540556 0.769 rs627670 chr1:209929299 G/A cg23920097 chr1:209922102 NA 0.38 5.31 0.31 2.27e-7 Red blood cell count; CESC cis rs7937682 1.000 rs505372 chr11:111507189 A/C cg22437258 chr11:111473054 SIK2 0.71 9.59 0.51 6.77e-19 Primary sclerosing cholangitis; CESC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg17294928 chr15:75287854 SCAMP5 0.47 6.23 0.36 1.81e-9 Breast cancer; CESC trans rs7824557 0.527 rs2572376 chr8:11237756 C/A cg06636001 chr8:8085503 FLJ10661 -0.48 -6.13 -0.35 3.25e-9 Retinal vascular caliber; CESC trans rs16893526 1.000 rs35392002 chr6:82558665 T/C cg07163173 chr2:67624373 ETAA1 0.83 6.31 0.36 1.14e-9 Coronary heart disease; CESC cis rs11645898 0.935 rs4788605 chr16:72154682 G/T cg14768367 chr16:72042858 DHODH -0.66 -5.84 -0.34 1.56e-8 Blood protein levels; CESC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg11494091 chr17:61959527 GH2 0.72 12.39 0.61 4.12e-28 Prudent dietary pattern; CESC cis rs9926296 0.585 rs8058009 chr16:89856439 G/C cg02875869 chr16:89901417 SPIRE2 -0.64 -7.48 -0.42 1.09e-12 Vitiligo; CESC cis rs524281 0.773 rs10750781 chr11:66037270 A/G cg14036092 chr11:66035641 RAB1B -0.55 -5.38 -0.31 1.62e-7 Electroencephalogram traits; CESC cis rs807669 0.903 rs807668 chr22:19162686 A/G cg02655711 chr22:19163373 SLC25A1 0.99 14.81 0.67 1.47e-36 Metabolite levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05821866 chr1:167905319 DCAF6;BRP44 0.52 6.85 0.39 5.05e-11 Gut microbiota (bacterial taxa); CESC cis rs6732160 0.588 rs1430344 chr2:73373344 G/A cg01422370 chr2:73384389 NA 0.57 9.1 0.49 2.29e-17 Intelligence (multi-trait analysis); CESC trans rs66573146 1.000 rs28384174 chr4:6961107 G/T cg07817883 chr1:32538562 TMEM39B 1.36 8.74 0.47 2.78e-16 Granulocyte percentage of myeloid white cells; CESC cis rs13242816 1.000 rs36004201 chr7:116126310 C/A cg04696780 chr7:116139425 CAV2 -0.62 -5.68 -0.33 3.58e-8 P wave duration; CESC cis rs2479724 0.905 rs2149274 chr6:41839092 T/C cg08135965 chr6:41755394 TOMM6 0.4 5.55 0.32 6.92e-8 Menarche (age at onset); CESC cis rs17039065 0.834 rs17039112 chr4:109439739 G/A cg16022748 chr4:109541635 LOC285456;RPL34 0.65 6.06 0.35 4.68e-9 Gut microbiome composition (summer); CESC cis rs7605827 0.675 rs2111449 chr2:15616215 C/T cg19274914 chr2:15703543 NA 0.32 5.19 0.3 4.15e-7 Educational attainment (years of education); CESC cis rs10791323 0.572 rs1114367 chr11:133737304 G/T cg03690763 chr11:133734501 NA -0.31 -5.15 -0.3 5.07e-7 Childhood ear infection; CESC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs10411936 0.712 rs8103521 chr19:16589750 A/G cg10248733 chr19:16607483 C19orf44;CALR3 0.56 6.7 0.38 1.27e-10 White blood cell count;Multiple sclerosis; CESC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg08888203 chr3:10149979 C3orf24 0.53 6.83 0.39 5.8200000000000003e-11 Alzheimer's disease; CESC cis rs4604732 0.631 rs1106719 chr1:247624713 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 -0.43 -5.48 -0.32 9.86e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2486288 0.656 rs11632419 chr15:45557456 C/A cg21132104 chr15:45694354 SPATA5L1 -0.55 -6.71 -0.38 1.16e-10 Glomerular filtration rate; CESC cis rs9649465 1.000 rs2109725 chr7:123325459 C/T cg04330084 chr7:123175371 IQUB -0.38 -5.22 -0.31 3.69e-7 Migraine; CESC cis rs116095464 0.558 rs10057626 chr5:239720 T/G cg22857025 chr5:266934 NA -1.29 -18.85 -0.76 7.29e-51 Breast cancer; CESC cis rs4969178 0.965 rs12450500 chr17:76395750 C/T cg05887092 chr17:76393375 PGS1 0.58 9.22 0.49 9.9e-18 HDL cholesterol levels; CESC cis rs6835098 0.962 rs4377567 chr4:174083590 C/G cg08422745 chr4:174089978 GALNT7 0.83 11.8 0.59 4.07e-26 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs854765 0.583 rs4257260 chr17:17857003 A/G cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg04267008 chr7:1944627 MAD1L1 -0.63 -7.87 -0.44 9.09e-14 Bipolar disorder and schizophrenia; CESC cis rs2718058 0.515 rs1584611 chr7:37874039 T/C cg15028436 chr7:37888078 TXNDC3 0.34 5.59 0.32 5.61e-8 Alzheimer's disease (late onset); CESC cis rs1707322 0.789 rs7540578 chr1:46252144 C/T cg05343316 chr1:45956843 TESK2 0.49 6.02 0.35 5.87e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2742234 0.541 rs11238476 chr10:43711436 G/T cg07801480 chr10:43725741 RASGEF1A -0.41 -5.25 -0.31 3.08e-7 Hirschsprung disease; CESC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg11859384 chr17:80120422 CCDC57 0.4 5.5 0.32 8.88e-8 Life satisfaction; CESC cis rs6540559 0.673 rs17015330 chr1:210012795 T/G cg25204440 chr1:209979598 IRF6 0.52 5.15 0.3 5.05e-7 Cleft lip with or without cleft palate; CESC cis rs6598955 0.724 rs10902731 chr1:26600793 A/G cg00852783 chr1:26633632 UBXN11 0.42 6.19 0.36 2.27e-9 Obesity-related traits; CESC cis rs1348850 0.914 rs4893957 chr2:178380409 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.88 12.65 0.61 5.06e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs904092 0.592 rs1229969 chr4:100206718 C/T cg12011299 chr4:100065546 ADH4 -0.55 -6.3 -0.36 1.23e-9 Alcohol dependence; CESC cis rs1879734 0.773 rs67319173 chr1:54133723 T/A cg23596471 chr1:54105337 GLIS1 0.37 5.69 0.33 3.44e-8 Mitral valve prolapse; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10651637 chr15:45315642 SORD -0.42 -6.18 -0.35 2.36e-9 Fibrinogen levels; CESC cis rs72627123 0.867 rs112965033 chr14:74461117 T/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.75 5.27 0.31 2.89e-7 Morning vs. evening chronotype; CESC cis rs763121 0.853 rs4821810 chr22:39072098 C/G cg06544989 chr22:39130855 UNC84B 0.52 9.99 0.52 3.63e-20 Menopause (age at onset); CESC cis rs12822507 0.811 rs34946234 chr12:12781812 A/G cg04607235 chr12:12878440 APOLD1 -0.5 -6.45 -0.37 5.29e-10 Systemic lupus erythematosus; CESC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg16278512 chr7:12443529 VWDE -0.55 -5.87 -0.34 1.27e-8 Coronary artery disease; CESC cis rs8114671 0.628 rs6060130 chr20:33549319 C/T cg07148914 chr20:33460835 GGT7 0.44 5.75 0.33 2.44e-8 Height; CESC cis rs13102973 0.965 rs13142779 chr4:135872841 G/T cg14419869 chr4:135874104 NA 0.36 5.76 0.33 2.37e-8 Subjective well-being; CESC cis rs2274273 0.901 rs112870553 chr14:55790062 T/G cg04306507 chr14:55594613 LGALS3 0.32 6.38 0.36 8.01e-10 Protein biomarker; CESC cis rs2933343 0.661 rs2630259 chr3:128606322 C/T cg25356066 chr3:128598488 ACAD9 0.66 9.18 0.49 1.27e-17 IgG glycosylation; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26297968 chr2:211035960 C2orf67 0.38 6.06 0.35 4.73e-9 Gambling; CESC cis rs916888 0.773 rs199533 chr17:44828931 G/A cg15921436 chr17:44337874 NA 0.74 8.01 0.44 3.59e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7618501 1.000 rs2271961 chr3:49878113 C/T cg24308560 chr3:49941425 MST1R 0.52 7.15 0.4 8.3e-12 Intelligence (multi-trait analysis); CESC cis rs9948 0.529 rs2139406 chr2:97366779 A/G cg01990225 chr2:97406019 LMAN2L -0.75 -6.9 -0.39 3.88e-11 Erectile dysfunction and prostate cancer treatment; CESC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg27165867 chr14:105738592 BRF1 -0.52 -5.59 -0.32 5.65e-8 Mean platelet volume;Platelet distribution width; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08588859 chr8:128903227 PVT1 -0.47 -6.25 -0.36 1.61e-9 Systemic lupus erythematosus; CESC cis rs963731 0.649 rs78905728 chr2:39339241 G/T cg04010122 chr2:39346883 SOS1 0.76 5.65 0.33 4.06e-8 Corticobasal degeneration; CESC cis rs11227306 0.934 rs2234458 chr11:65639374 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.46 -5.24 -0.31 3.21e-7 DNA methylation (variation); CESC cis rs7116495 0.609 rs2735787 chr11:71717873 T/C cg07596299 chr11:71824057 C11orf51 -0.81 -5.35 -0.31 1.95e-7 Severe influenza A (H1N1) infection; CESC cis rs3813567 0.702 rs7164665 chr15:78953919 T/C cg05914723 chr15:78953907 NA 0.45 5.77 0.33 2.24e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18997990 chr15:44084145 SERF2 -0.57 -6.55 -0.37 2.94e-10 Gut microbiome composition (summer); CESC cis rs1371867 0.846 rs1660346 chr8:101312497 A/G cg11906718 chr8:101322791 RNF19A 0.54 6.93 0.39 3.1e-11 Atrioventricular conduction; CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg19268477 chr7:157951471 PTPRN2 0.32 6.39 0.37 7.44e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg11890956 chr21:40555474 PSMG1 1.18 22.66 0.81 6.1e-64 Cognitive function; CESC trans rs2764766 0.721 rs151881 chr5:127188432 A/T cg15764593 chr10:829463 NA -0.4 -6.19 -0.36 2.33e-9 Schizophrenia; CESC cis rs796364 0.951 rs971232 chr2:200792881 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.86 8.47 0.46 1.75e-15 Schizophrenia; CESC cis rs6570726 0.905 rs419575 chr6:145840174 A/G cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.36e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 10.57 0.54 4.92e-22 Platelet count; CESC cis rs7119 0.717 rs34194537 chr15:77795761 G/A cg17802220 chr15:77601643 NA -0.52 -7.15 -0.4 8.61e-12 Type 2 diabetes; CESC cis rs9300255 0.596 rs11057207 chr12:123730891 T/G cg19016782 chr12:123741754 C12orf65 -0.36 -5.3 -0.31 2.43e-7 Neutrophil percentage of white cells; CESC cis rs12973672 0.904 rs10424619 chr19:35768237 A/T cg12095397 chr19:35769544 USF2 0.55 7.12 0.4 1.03e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs826838 1.000 rs1393537 chr12:38920961 C/T cg26384229 chr12:38710491 ALG10B 0.82 14.44 0.66 2.91e-35 Heart rate; CESC trans rs853679 0.546 rs34295134 chr6:27828151 T/A cg06606381 chr12:133084897 FBRSL1 -0.82 -7.68 -0.43 3.01e-13 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11767426 chr14:50319892 SDCCAG1 -0.5 -6.18 -0.35 2.46e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09225442 chr16:30662040 PRR14 -0.46 -6.14 -0.35 2.93e-9 Fibrinogen levels; CESC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2730245 0.569 rs1188955 chr7:158690866 A/G cg01943577 chr7:158741284 NA -0.4 -5.21 -0.3 3.78e-7 Height; CESC cis rs2294693 0.947 rs736795 chr6:40998141 G/A cg14418226 chr6:40996092 UNC5CL 0.54 6.77 0.38 8.07e-11 Gastric cancer;Non-cardia gastric cancer; CESC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16506072 chr16:85833520 COX4NB;COX4I1 -0.47 -6.11 -0.35 3.64e-9 Ulcerative colitis; CESC cis rs929596 0.556 rs10202865 chr2:234587707 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -5.64 -0.33 4.32e-8 Total bilirubin levels in HIV-1 infection; CESC cis rs2288912 0.807 rs3760626 chr19:45457105 A/G cg13119609 chr19:45449297 APOC2 0.49 8.03 0.44 3.23e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9640161 0.750 rs4395803 chr7:150025367 A/C cg27494647 chr7:150038898 RARRES2 0.41 5.11 0.3 6.15e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs7481584 0.581 rs366422 chr11:3053873 C/T cg08508325 chr11:3079039 CARS 0.29 5.19 0.3 4.29e-7 Calcium levels; CESC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg21856205 chr7:94953877 PON1 -0.51 -7.96 -0.44 5.21e-14 Paraoxonase activity; CESC trans rs637571 0.522 rs550435 chr11:65732651 G/A cg17712092 chr4:129076599 LARP1B 0.69 9.58 0.51 7.33e-19 Eosinophil percentage of white cells; CESC cis rs8017423 1.000 rs4904644 chr14:90665689 A/G cg14092571 chr14:90743983 NA 0.52 7.7 0.43 2.63e-13 Mortality in heart failure; CESC cis rs9611565 0.568 rs5758441 chr22:42132888 C/A cg06481639 chr22:41940642 POLR3H 0.5 5.81 0.34 1.78e-8 Vitiligo; CESC cis rs8067354 0.574 rs2250526 chr17:57951973 G/A cg13753209 chr17:57696993 CLTC 0.52 5.69 0.33 3.4e-8 Hemoglobin concentration; CESC cis rs10927875 0.864 rs6674071 chr1:16144855 G/C cg21385522 chr1:16154831 NA -0.93 -11.81 -0.59 3.99e-26 Dilated cardiomyopathy; CESC trans rs629535 0.814 rs506931 chr8:70068129 T/G cg21567404 chr3:27674614 NA 0.88 10.34 0.54 2.74e-21 Dupuytren's disease; CESC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg18765753 chr7:1198926 ZFAND2A -0.41 -5.21 -0.31 3.72e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.649 rs5751108 chr22:41858035 T/C cg03806693 chr22:41940476 POLR3H 1.19 14.53 0.67 1.37e-35 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01688293 chr12:133428407 CHFR 0.45 6.14 0.35 2.99e-9 Fibrinogen levels; CESC cis rs763121 0.889 rs9607557 chr22:39040279 G/A cg21395723 chr22:39101663 GTPBP1 0.45 5.92 0.34 1.01e-8 Menopause (age at onset); CESC cis rs12579753 0.879 rs11115008 chr12:82164859 C/T cg24719984 chr12:82153464 PPFIA2 -0.36 -5.28 -0.31 2.64e-7 Resting heart rate; CESC trans rs2727020 0.930 rs1164688 chr11:49290604 C/G cg03929089 chr4:120376271 NA 0.71 9.26 0.49 7.34e-18 Coronary artery disease; CESC cis rs4604732 0.527 rs7546805 chr1:247627259 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.46 0.32 1.09e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg26338869 chr17:61819248 STRADA 0.66 8.51 0.46 1.27e-15 Prudent dietary pattern; CESC cis rs854765 0.505 rs4506969 chr17:17899839 A/G cg09796270 chr17:17721594 SREBF1 0.37 5.15 0.3 5.12e-7 Total body bone mineral density; CESC trans rs60843830 1.000 rs17714252 chr2:285471 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 8.31 0.45 4.98e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs17384381 1.000 rs12140170 chr1:85849723 G/A cg16011679 chr1:85725395 C1orf52 0.79 8.08 0.44 2.34e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.72 0.62 2.88e-29 Alzheimer's disease; CESC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg13722127 chr7:150037890 RARRES2 0.38 5.27 0.31 2.87e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs6831352 0.734 rs1311620 chr4:100013091 C/T cg12011299 chr4:100065546 ADH4 0.59 7.16 0.4 7.75e-12 Alcohol dependence; CESC cis rs10088262 0.629 rs1367829 chr8:124797135 A/G cg02993010 chr8:124780839 FAM91A1 -0.67 -8.55 -0.46 1.01e-15 Pancreatic cancer; CESC cis rs3947 1.000 rs2645425 chr8:11701278 G/A cg00262122 chr8:11665843 FDFT1 -0.5 -5.15 -0.3 5.07e-7 Blood protein levels; CESC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.66 7.68 0.43 3.11e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17376456 1.000 rs35184505 chr5:93561535 A/G cg25358565 chr5:93447407 FAM172A 1.16 10.76 0.55 1.2e-22 Diabetic retinopathy; CESC cis rs1707322 0.896 rs785518 chr1:46568422 A/T cg03146154 chr1:46216737 IPP -0.69 -9.13 -0.49 1.84e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1801251 0.896 rs7573208 chr2:233696701 C/A cg08000102 chr2:233561755 GIGYF2 -0.73 -11.63 -0.58 1.55e-25 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22855052 chr12:6982535 SPSB2 -0.46 -6.62 -0.38 1.94e-10 Fibrinogen levels; CESC cis rs12597458 0.752 rs8051239 chr16:72036257 T/A cg16558253 chr16:72132732 DHX38 0.38 5.53 0.32 7.76e-8 Prostate cancer; CESC cis rs4423214 0.879 rs1792282 chr11:71135166 G/A cg05163923 chr11:71159392 DHCR7 -0.59 -6.82 -0.39 6e-11 Vitamin D levels; CESC cis rs870825 0.616 rs28459754 chr4:185636280 C/A cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.41 -0.32 1.39e-7 Aortic root size; CESC cis rs698833 0.518 rs7562945 chr2:44552772 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.19 0.3 4.17e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9815354 0.812 rs58442057 chr3:41827209 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg19193384 chr17:30244184 NA -0.7 -6.62 -0.38 2e-10 Hip circumference adjusted for BMI; CESC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg08392591 chr16:89556376 ANKRD11 0.59 8.07 0.44 2.49e-14 Multiple myeloma (IgH translocation); CESC cis rs2816062 0.760 rs2244192 chr1:18890939 A/T cg18795169 chr1:18902165 NA -0.95 -18.57 -0.75 7.28e-50 Urate levels in lean individuals; CESC cis rs9815354 0.680 rs73075219 chr3:42038429 A/C cg03022575 chr3:42003672 ULK4 0.75 6.57 0.37 2.63e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs9894429 0.789 rs35887231 chr17:79587126 G/A cg13777783 chr17:79615861 NA -0.33 -5.24 -0.31 3.35e-7 Eye color traits; CESC cis rs9916302 0.904 rs12450559 chr17:37694709 G/A cg07936489 chr17:37558343 FBXL20 -0.8 -11.52 -0.58 3.68e-25 Glomerular filtration rate (creatinine); CESC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.68 -7.61 -0.42 4.86e-13 Gut microbiome composition (summer); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg07181902 chr2:85829892 TMEM150A 0.48 6.01 0.35 6.17e-9 Breast cancer;Type 2 diabetes; CESC cis rs568617 1.000 rs656980 chr11:65656282 G/A cg19792802 chr11:65647270 CTSW 0.36 5.44 0.32 1.24e-7 Crohn's disease; CESC cis rs7267979 0.966 rs2424714 chr20:25418681 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 3e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs2742234 0.590 rs2435338 chr10:43642115 A/G cg07801480 chr10:43725741 RASGEF1A 0.42 5.31 0.31 2.34e-7 Hirschsprung disease; CESC cis rs4919694 0.572 rs7080935 chr10:104929113 C/A cg04362960 chr10:104952993 NT5C2 0.64 6.44 0.37 5.66e-10 Arsenic metabolism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25223263 chr11:119020168 ABCG4 0.62 7.69 0.43 2.92e-13 Gut microbiome composition (summer); CESC cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg03060546 chr3:49711283 APEH 0.44 5.38 0.31 1.61e-7 Parkinson's disease; CESC cis rs7216064 0.954 rs4790973 chr17:65951133 C/T cg07042672 chr17:66097459 LOC651250 -0.54 -5.8 -0.34 1.84e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs17826219 0.706 rs8075357 chr17:29057197 A/C cg13385521 chr17:29058706 SUZ12P 0.81 6.53 0.37 3.28e-10 Body mass index; CESC cis rs1707322 0.685 rs28617418 chr1:46189526 T/A cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs59918340 0.728 rs4961340 chr8:142232002 G/A cg23750338 chr8:142222470 SLC45A4 0.64 9.83 0.52 1.18e-19 Immature fraction of reticulocytes; CESC trans rs208520 0.690 rs851468 chr6:66825875 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -12.92 -0.62 5.99e-30 Exhaled nitric oxide output; CESC cis rs9486719 0.948 rs2472881 chr6:96862562 C/T cg18709589 chr6:96969512 KIAA0776 0.52 5.67 0.33 3.8e-8 Migraine;Coronary artery disease; CESC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg13206674 chr6:150067644 NUP43 0.41 5.92 0.34 1.02e-8 Lung cancer; CESC cis rs116095464 0.558 rs10055405 chr5:265666 C/T cg22496380 chr5:211416 CCDC127 -0.73 -8.29 -0.45 5.78e-15 Breast cancer; CESC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.33e-10 Skin colour saturation; CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg16145915 chr7:1198662 ZFAND2A -0.47 -5.48 -0.32 9.95e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6088590 1.000 rs6119535 chr20:33442138 A/C cg24642439 chr20:33292090 TP53INP2 0.76 10.42 0.54 1.57e-21 Coronary artery disease; CESC cis rs863345 0.526 rs857676 chr1:158615702 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -5.76 -0.33 2.27e-8 Pneumococcal bacteremia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11333835 chr1:23495430 LUZP1 -0.62 -7.42 -0.41 1.56e-12 Gut microbiome composition (summer); CESC cis rs6867032 0.527 rs4371796 chr5:1977785 C/T cg26168224 chr5:2018326 NA -0.75 -10.31 -0.54 3.53e-21 Gut microbiome composition (winter); CESC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg04553112 chr3:125709451 NA -0.51 -5.69 -0.33 3.36e-8 Blood pressure (smoking interaction); CESC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg12963246 chr6:28129442 ZNF389 0.39 5.6 0.33 5.36e-8 Parkinson's disease; CESC trans rs4950322 0.570 rs72691004 chr1:146705955 G/A cg04954894 chr8:38089920 DDHD2 -0.58 -6.17 -0.35 2.55e-9 Protein quantitative trait loci; CESC cis rs524281 0.773 rs10791862 chr11:66013664 T/C cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.38e-7 Electroencephalogram traits; CESC cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg26597838 chr10:835615 NA 0.76 7.14 0.4 8.95e-12 Eosinophil percentage of granulocytes; CESC cis rs2243480 1.000 rs4718334 chr7:65789454 G/A cg18252515 chr7:66147081 NA 1.27 12.94 0.62 4.98e-30 Diabetic kidney disease; CESC cis rs10465746 0.545 rs12145516 chr1:84480376 A/G cg10977910 chr1:84465055 TTLL7 0.45 5.65 0.33 4.17e-8 Obesity-related traits; CESC cis rs7095944 0.554 rs11245344 chr10:126418782 C/T cg08799069 chr10:126477246 METTL10 -0.4 -5.91 -0.34 1.07e-8 Asthma; CESC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.06 0.6 5.29e-27 Alzheimer's disease; CESC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 9.67 0.51 3.9e-19 Alzheimer's disease; CESC cis rs2816062 0.786 rs2745317 chr1:18896552 G/A cg18795169 chr1:18902165 NA -0.94 -19.04 -0.76 1.61e-51 Urate levels in lean individuals; CESC cis rs9916302 0.904 rs11867312 chr17:37597748 C/T cg07936489 chr17:37558343 FBXL20 -0.8 -11.5 -0.58 4.2e-25 Glomerular filtration rate (creatinine); CESC cis rs2070677 0.877 rs1581935 chr10:135360448 T/G cg20169779 chr10:135381914 SYCE1 0.75 9.01 0.48 4.31e-17 Gout; CESC cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg27572855 chr1:25598939 RHD 0.44 7.28 0.41 3.8e-12 Erythrocyte sedimentation rate; CESC cis rs8078723 1.000 rs2227336 chr17:38174855 T/G cg17467752 chr17:38218738 THRA 0.66 9.91 0.52 6.68e-20 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs2075371 0.796 rs1643040 chr7:134011703 G/C cg20476274 chr7:133979776 SLC35B4 0.53 7.21 0.41 5.79e-12 Mean platelet volume; CESC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg23555592 chr10:91174309 IFIT5 -0.51 -6.27 -0.36 1.5e-9 Thyroid stimulating hormone; CESC trans rs10435719 0.647 rs10092605 chr8:11787395 T/G cg15556689 chr8:8085844 FLJ10661 0.51 6.29 0.36 1.3e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs858239 0.539 rs4365988 chr7:23190871 T/C cg23682824 chr7:23144976 KLHL7 0.51 6.77 0.38 8.05e-11 Cerebrospinal fluid biomarker levels; CESC cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg05347473 chr6:146136440 FBXO30 0.55 7.06 0.4 1.45e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6741892 0.536 rs7590835 chr2:38893950 A/G cg19391498 chr2:38892846 GALM 0.53 7.28 0.41 3.81e-12 5-HTT brain serotonin transporter levels; CESC trans rs10242455 0.557 rs45529541 chr7:99048143 C/A cg09045935 chr12:6379348 NA 0.92 7.49 0.42 9.97e-13 Blood metabolite levels; CESC cis rs2243480 1.000 rs36068983 chr7:65408991 C/T cg18252515 chr7:66147081 NA -1.06 -9.79 -0.52 1.67e-19 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09304653 chr7:141251275 AGK 0.53 6.06 0.35 4.69e-9 Gut microbiome composition (summer); CESC cis rs11690935 0.959 rs12692970 chr2:172594197 T/C cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.99 -0.68 3.42e-37 Schizophrenia; CESC cis rs6568686 0.627 rs174374 chr6:111906055 A/G cg22127309 chr6:111907043 TRAF3IP2 0.5 5.08 0.3 7.07e-7 Depressive and manic episodes in bipolar disorder;Depressive episodes in bipolar disorder; CESC trans rs208520 0.955 rs12204033 chr6:67001525 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 8.7 0.47 3.56e-16 Exhaled nitric oxide output; CESC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg20151795 chr6:28129481 ZNF389 0.46 5.83 0.34 1.65e-8 Depression; CESC cis rs1801251 0.964 rs6748027 chr2:233629552 T/C cg25237894 chr2:233734115 C2orf82 0.45 7.9 0.44 7.6e-14 Coronary artery disease; CESC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03934478 chr11:495069 RNH1 0.53 5.34 0.31 2.03e-7 Body mass index; CESC cis rs7208859 0.725 rs7210904 chr17:29170205 G/A cg19761014 chr17:28927070 LRRC37B2 0.56 5.68 0.33 3.47e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs258892 0.895 rs16901102 chr5:72048749 C/T cg21869765 chr5:72125136 TNPO1 -0.4 -5.17 -0.3 4.51e-7 Small cell lung carcinoma; CESC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.92 10.16 0.53 1.05e-20 Mean platelet volume; CESC cis rs7107174 1.000 rs10899455 chr11:77999163 T/C cg02023728 chr11:77925099 USP35 0.43 6.05 0.35 4.97e-9 Testicular germ cell tumor; CESC cis rs4969178 0.965 rs4969179 chr17:76391454 A/C cg20026190 chr17:76395443 PGS1 0.49 7.84 0.43 1.13e-13 HDL cholesterol levels; CESC cis rs250677 0.522 rs2895837 chr5:148357535 C/T cg18129178 chr5:148520854 ABLIM3 0.5 5.45 0.32 1.13e-7 Breast cancer; CESC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg13770153 chr20:60521292 NA -0.44 -5.7 -0.33 3.2e-8 Body mass index; CESC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg24739457 chr1:205821442 NA -0.44 -6.14 -0.35 3.02e-9 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05592363 chr5:78908495 PAPD4 0.56 6.71 0.38 1.18e-10 Gut microbiome composition (summer); CESC cis rs826838 0.874 rs11183816 chr12:38834656 T/G cg13010199 chr12:38710504 ALG10B 0.6 8.53 0.46 1.18e-15 Heart rate; CESC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg10691866 chr7:65817282 TPST1 0.33 5.59 0.32 5.54e-8 Aortic root size; CESC cis rs9633740 0.947 rs7096909 chr10:82284512 A/T cg00277334 chr10:82204260 NA 0.52 5.44 0.32 1.23e-7 Post bronchodilator FEV1; CESC cis rs78889164 0.955 rs77339594 chr19:33855252 C/A cg02272751 chr19:33882848 PEPD -0.51 -6.46 -0.37 5.02e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg02108556 chr8:131271127 ASAP1 0.42 6.67 0.38 1.45e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11098499 0.909 rs35111518 chr4:120440682 A/G cg24375607 chr4:120327624 NA 0.44 5.27 0.31 2.85e-7 Corneal astigmatism; CESC cis rs9905704 0.633 rs2531731 chr17:56546524 A/C cg12560992 chr17:57184187 TRIM37 -0.63 -5.75 -0.33 2.48e-8 Testicular germ cell tumor; CESC cis rs4803468 1.000 rs10853751 chr19:41903220 G/A cg09537434 chr19:41945824 ATP5SL -1.06 -19.22 -0.76 3.86e-52 Height; CESC cis rs9393777 0.623 rs2093169 chr6:26495099 C/T cg14345882 chr6:26364793 BTN3A2 0.44 5.34 0.31 2.01e-7 Intelligence (multi-trait analysis); CESC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg22535103 chr8:58192502 C8orf71 -1.04 -13.21 -0.63 5.76e-31 Developmental language disorder (linguistic errors); CESC cis rs6430585 0.528 rs309119 chr2:136710372 T/C cg07169764 chr2:136633963 MCM6 1.08 15.44 0.69 8.54e-39 Corneal structure; CESC cis rs13191362 0.810 rs13209784 chr6:162961274 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 7.21 0.4 5.86e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg11301795 chr4:187892539 NA -0.72 -10.8 -0.55 8.89e-23 Lobe attachment (rater-scored or self-reported); CESC trans rs6700559 0.810 rs2809344 chr1:200596606 C/A cg05185519 chr16:2972941 FLYWCH1 0.47 6.16 0.35 2.73e-9 Coronary artery disease; CESC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg02711726 chr17:80685570 FN3KRP -0.39 -5.14 -0.3 5.32e-7 Glycated hemoglobin levels; CESC cis rs9291683 0.609 rs3796836 chr4:10011345 A/G cg00071950 chr4:10020882 SLC2A9 0.89 17.05 0.72 1.7e-44 Bone mineral density; CESC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.75 10.57 0.54 5.21e-22 Prudent dietary pattern; CESC cis rs7927592 0.913 rs7925275 chr11:68290433 T/C cg20283391 chr11:68216788 NA -0.62 -7.54 -0.42 7.69e-13 Total body bone mineral density; CESC cis rs4955124 0.818 rs12639463 chr3:32042746 G/A cg05935571 chr3:32023257 ZNF860;OSBPL10 0.67 5.33 0.31 2.14e-7 Schizophrenia; CESC cis rs763121 0.752 rs5757222 chr22:39060473 C/T cg06544989 chr22:39130855 UNC84B 0.49 8.49 0.46 1.53e-15 Menopause (age at onset); CESC cis rs1707322 0.752 rs11211171 chr1:46168642 A/G cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2488856 0.504 rs2455971 chr14:43540163 A/T cg09730170 chr20:23586680 CST9 0.41 6.54 0.37 3.18e-10 Osteoprotegerin levels; CESC cis rs75804782 0.521 rs72982596 chr2:239454919 G/C cg18131467 chr2:239335373 ASB1 -0.69 -5.57 -0.32 6.11e-8 Morning vs. evening chronotype;Chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22152050 chr18:60987904 BCL2 0.56 6.22 0.36 1.97e-9 Gut microbiome composition (summer); CESC cis rs898097 0.801 rs68141193 chr17:80878816 C/T cg15369054 chr17:80825471 TBCD 0.51 7.18 0.4 6.87e-12 Breast cancer; CESC cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg16339924 chr4:17578868 LAP3 0.56 7.02 0.4 1.91e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3125734 0.660 rs4979780 chr10:63992740 A/C cg09941381 chr10:64027924 RTKN2 -0.31 -5.14 -0.3 5.41e-7 Rheumatoid arthritis; CESC cis rs3806843 0.966 rs3806844 chr5:140206263 A/T cg26395211 chr5:140044315 WDR55 -0.42 -5.14 -0.3 5.3e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1707322 0.716 rs28375469 chr1:46195375 T/C cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2273669 0.667 rs7767882 chr6:109334971 C/A cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs4148883 0.689 rs1154415 chr4:99999033 T/C cg13256891 chr4:100009986 ADH5 0.52 6.81 0.39 6.69e-11 Alcohol dependence; CESC cis rs6060717 0.528 rs73905955 chr20:34332938 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.48 -0.42 1.09e-12 Hip circumference adjusted for BMI; CESC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg11494091 chr17:61959527 GH2 -0.78 -13.9 -0.65 2.38e-33 Prudent dietary pattern; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg09311052 chr1:154531418 UBE2Q1 0.48 6.38 0.36 7.87e-10 Tetralogy of Fallot; CESC cis rs6690583 0.623 rs12037219 chr1:85505951 G/A cg22153463 chr1:85462885 MCOLN2 0.78 7.43 0.42 1.49e-12 Serum sulfate level; CESC cis rs2243480 0.901 rs1701759 chr7:65470932 G/T cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg19468946 chr17:37922297 IKZF3 0.39 5.09 0.3 6.85e-7 Glomerular filtration rate (creatinine); CESC cis rs4268898 0.931 rs2551121 chr2:24539967 T/C cg06627628 chr2:24431161 ITSN2 -0.71 -8.59 -0.47 7.69e-16 Asthma; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14851846 chr7:99716985 TAF6;CNPY4 -0.49 -6.15 -0.35 2.86e-9 Ulcerative colitis; CESC cis rs4656958 0.538 rs2184066 chr1:160883896 G/C cg20012024 chr1:160991549 F11R 0.29 5.06 0.3 7.72e-7 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CESC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg15445000 chr17:37608096 MED1 0.41 6.76 0.38 8.83e-11 Glomerular filtration rate (creatinine); CESC trans rs13063635 0.831 rs35209528 chr3:46003496 T/C cg10236987 chr1:228114221 WNT9A 0.57 6.07 0.35 4.38e-9 Eosinophil percentage of granulocytes; CESC cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC trans rs11098499 0.954 rs10024844 chr4:120311528 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs67311347 1.000 rs4128740 chr3:40519532 C/A cg09455208 chr3:40491958 NA 0.52 8.64 0.47 5.57e-16 Renal cell carcinoma; CESC trans rs5763662 1.000 rs5763763 chr22:30488627 G/A cg23513814 chr17:72857430 GRIN2C -0.53 -6.0 -0.35 6.28e-9 LDL cholesterol levels;LDL cholesterol; CESC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.68 0.61 4e-29 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg24048372 chr5:93954560 C5orf36;ANKRD32 -0.47 -6.11 -0.35 3.47e-9 Ulcerative colitis; CESC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg08499158 chr17:42289980 UBTF -0.56 -7.32 -0.41 2.94e-12 Total body bone mineral density; CESC cis rs73206853 0.764 rs55991901 chr12:110962702 C/A cg12870014 chr12:110450643 ANKRD13A 0.62 5.2 0.3 3.98e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15323937 chr11:64599019 CDC42BPG -0.55 -6.16 -0.35 2.7e-9 Gut microbiome composition (summer); CESC cis rs9399401 0.667 rs7757571 chr6:142702589 A/C cg04461802 chr6:142623433 GPR126 0.36 5.4 0.31 1.52e-7 Chronic obstructive pulmonary disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21063480 chr14:78082891 SPTLC2 0.63 6.94 0.39 2.92e-11 Gut microbiome composition (summer); CESC cis rs77106637 0.858 rs7109575 chr11:72463435 G/A cg03713592 chr11:72463424 ARAP1 1.26 10.6 0.55 4.01e-22 Type 2 diabetes; CESC cis rs4727027 0.933 rs34578816 chr7:148847606 G/A cg23158103 chr7:148848205 ZNF398 -0.43 -7.11 -0.4 1.06e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg17372223 chr3:52568218 NT5DC2 -0.39 -6.07 -0.35 4.47e-9 Bipolar disorder; CESC cis rs3008870 0.755 rs2755254 chr1:67470855 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.62 8.12 0.45 1.73e-14 Lymphocyte percentage of white cells; CESC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.54 0.54 6.22e-22 Height; CESC cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg22875332 chr1:76189707 ACADM 0.66 7.81 0.43 1.31e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs637571 0.544 rs55704213 chr11:65730002 C/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 6.22 0.36 1.92e-9 Eosinophil percentage of white cells; CESC cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg20891283 chr12:69753455 YEATS4 0.91 15.03 0.68 2.41e-37 Blood protein levels; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22418859 chr21:37518821 CBR3 -0.45 -6.88 -0.39 4.34e-11 Intelligence (multi-trait analysis); CESC cis rs2933343 0.700 rs1683779 chr3:128642048 A/G cg25356066 chr3:128598488 ACAD9 0.62 8.76 0.47 2.42e-16 IgG glycosylation; CESC cis rs3820068 0.581 rs2861387 chr1:15951296 G/A cg17385448 chr1:15911702 AGMAT 0.43 6.87 0.39 4.57e-11 Systolic blood pressure; CESC cis rs3820068 0.603 rs17448778 chr1:15985306 A/G cg17385448 chr1:15911702 AGMAT 0.45 7.67 0.43 3.27e-13 Systolic blood pressure; CESC cis rs11083475 0.714 rs1471432 chr19:39260282 G/A cg26703956 chr19:39260304 NA -0.29 -5.41 -0.32 1.38e-7 Heart rate; CESC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21155778 chr12:95611301 FGD6;VEZT -0.49 -6.04 -0.35 5.09e-9 Ulcerative colitis; CESC cis rs9487051 0.676 rs7773775 chr6:109600339 T/C cg21918786 chr6:109611834 NA -0.37 -5.5 -0.32 9.15e-8 Reticulocyte fraction of red cells; CESC cis rs6835098 0.962 rs10014010 chr4:174083230 C/T cg08422745 chr4:174089978 GALNT7 -0.82 -11.83 -0.59 3.26e-26 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs4906332 0.966 rs12185021 chr14:103927805 A/G cg09975044 chr14:104007538 NA 0.47 6.45 0.37 5.25e-10 Coronary artery disease; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg08270031 chr1:180472207 ACBD6 -0.46 -6.26 -0.36 1.52e-9 Thyroid stimulating hormone; CESC cis rs12121840 0.790 rs16846756 chr1:165516102 C/T cg16553119 chr1:165599451 MGST3 -0.48 -5.26 -0.31 3.03e-7 Interleukin-1-receptor antagonist levels; CESC cis rs10504229 0.871 rs7002070 chr8:58153817 A/G cg22535103 chr8:58192502 C8orf71 -0.9 -11.03 -0.56 1.55e-23 Developmental language disorder (linguistic errors); CESC trans rs7618501 0.633 rs3774733 chr3:50037123 C/G cg21659725 chr3:3221576 CRBN 0.54 7.54 0.42 7.33e-13 Intelligence (multi-trait analysis); CESC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg02038168 chr22:39784481 NA -0.6 -7.21 -0.4 5.96e-12 Intelligence (multi-trait analysis); CESC cis rs1865721 1.000 rs17283692 chr18:73193911 T/C cg26385618 chr18:73139727 C18orf62 -0.51 -7.56 -0.42 6.81e-13 Intelligence; CESC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.43 5.84 0.34 1.56e-8 Menopause (age at onset); CESC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.83 0.34 1.59e-8 Bipolar disorder; CESC cis rs7149337 0.805 rs3007164 chr14:51646935 A/G cg23942311 chr14:51606299 NA 0.45 7.75 0.43 1.91e-13 Cancer; CESC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg25072359 chr17:41440525 NA 0.44 6.04 0.35 5.21e-9 Menopause (age at onset); CESC cis rs727505 1.000 rs66922607 chr7:124512555 T/A cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.49e-13 Lewy body disease; CESC cis rs4819052 0.851 rs2838867 chr21:46713092 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 12.96 0.62 4.35e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg19346786 chr7:2764209 NA -0.52 -7.46 -0.42 1.26e-12 Height; CESC cis rs6783573 0.965 rs7650998 chr3:46607255 C/T cg21489266 chr3:46619131 LRRC2;TDGF1 0.42 6.49 0.37 4.16e-10 Cerebrospinal fluid biomarker levels; CESC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.97 9.49 0.5 1.45e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs769267 0.930 rs747050 chr19:19584987 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.45 0.42 1.34e-12 Tonsillectomy; CESC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg04414720 chr1:150670196 GOLPH3L 0.45 5.95 0.34 8.58e-9 Melanoma; CESC trans rs853679 0.824 rs1321505 chr6:28052823 A/C cg06606381 chr12:133084897 FBRSL1 -0.66 -6.0 -0.35 6.41e-9 Depression; CESC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg11644478 chr21:40555479 PSMG1 1.02 16.67 0.72 3.53e-43 Cognitive function; CESC cis rs9400467 0.506 rs10456872 chr6:111586667 C/T cg15721981 chr6:111408429 SLC16A10 0.52 5.03 0.3 8.93e-7 Blood metabolite levels;Amino acid levels; CESC cis rs7660520 0.524 rs4862101 chr4:183733177 T/C cg04526738 chr4:183727387 NA 0.7 6.51 0.37 3.71e-10 Pediatric autoimmune diseases; CESC cis rs4594175 0.926 rs4131365 chr14:51622444 C/T cg23942311 chr14:51606299 NA 0.36 5.36 0.31 1.77e-7 Cancer; CESC trans rs7937682 0.847 rs583032 chr11:111432757 C/T cg18187862 chr3:45730750 SACM1L 0.51 6.22 0.36 1.88e-9 Primary sclerosing cholangitis; CESC cis rs7666738 0.791 rs1426661 chr4:98874303 C/G cg03467027 chr4:99064603 C4orf37 0.41 5.14 0.3 5.32e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7726839 0.574 rs72705017 chr5:623733 G/A cg16447950 chr5:562315 NA -0.59 -6.06 -0.35 4.72e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18252731 chr15:93198700 FAM174B -0.56 -6.61 -0.38 2.08e-10 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs451396 chr7:65484074 T/A cg12463550 chr7:65579703 CRCP 0.72 5.81 0.34 1.8e-8 Diabetic kidney disease; CESC cis rs116095464 0.681 rs9687745 chr5:229309 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.6 -0.47 7.1e-16 Breast cancer; CESC cis rs5753618 0.561 rs9609254 chr22:31705942 G/A cg13145458 chr22:31556086 RNF185 -0.49 -5.57 -0.32 6.36e-8 Colorectal cancer; CESC cis rs6674176 0.696 rs4448553 chr1:44411589 A/G cg23954153 chr1:44402353 ARTN -0.33 -5.06 -0.3 7.89e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs17253792 0.822 rs10142497 chr14:56047948 C/T cg01858014 chr14:56050164 KTN1 0.74 6.05 0.35 4.92e-9 Putamen volume; CESC cis rs3741151 0.686 rs11822984 chr11:73261467 A/C cg17517138 chr11:73019481 ARHGEF17 0.86 6.84 0.39 5.62e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs3761218 0.714 rs1968648 chr20:3763349 C/T cg25011176 chr20:3776985 CDC25B 0.43 5.95 0.34 8.44e-9 Bipolar disorder; CESC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg13114125 chr14:105738426 BRF1 0.82 10.11 0.53 1.54e-20 Mean platelet volume;Platelet distribution width; CESC cis rs9814567 0.806 rs2293294 chr3:134322814 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.42 5.56 0.32 6.59e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2933343 0.649 rs728839 chr3:128589359 A/G cg25356066 chr3:128598488 ACAD9 0.59 8.34 0.46 3.97e-15 IgG glycosylation; CESC cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg00033643 chr7:134001901 SLC35B4 0.44 5.6 0.33 5.4e-8 Mean platelet volume; CESC cis rs12973672 0.812 rs35250673 chr19:35762548 G/A cg12095397 chr19:35769544 USF2 0.48 5.68 0.33 3.46e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7635838 0.596 rs347598 chr3:11258289 G/C cg00170343 chr3:11313890 ATG7 0.54 7.58 0.42 5.88e-13 HDL cholesterol; CESC trans rs561341 0.883 rs886224 chr17:30229902 T/C cg20587970 chr11:113659929 NA -1.08 -13.13 -0.63 1.11e-30 Hip circumference adjusted for BMI; CESC cis rs754466 0.580 rs10824577 chr10:79577408 G/C cg17075019 chr10:79541650 NA -0.87 -13.8 -0.65 5.26e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9787249 0.957 rs7548120 chr1:40204424 A/T cg24920358 chr1:40204285 PPIE 0.43 6.47 0.37 4.74e-10 Blood protein levels; CESC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.7 6.21 0.36 2.04e-9 Platelet count; CESC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.99 10.67 0.55 2.36e-22 Platelet count; CESC cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg19717773 chr7:2847554 GNA12 -0.52 -8.4 -0.46 2.7e-15 Height; CESC cis rs2011503 0.941 rs11555053 chr19:19390185 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.5 5.04 0.3 8.44e-7 Bipolar disorder; CESC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 6.4 0.37 6.91e-10 Bipolar disorder; CESC cis rs10883723 0.810 rs2296581 chr10:104242886 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.29 0.41 3.52e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs2531992 0.800 rs2601782 chr16:4021051 T/C cg05927578 chr16:4029543 ADCY9 0.46 5.78 0.33 2.14e-8 Waist circumference; CESC cis rs2070488 0.965 rs2284819 chr3:38557161 C/T cg24069376 chr3:38537580 EXOG 0.44 7.68 0.43 2.99e-13 Electrocardiographic conduction measures; CESC cis rs67311347 1.000 rs11539046 chr3:40503809 G/A cg09455208 chr3:40491958 NA -0.48 -8.13 -0.45 1.65e-14 Renal cell carcinoma; CESC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg22535103 chr8:58192502 C8orf71 -1.03 -12.78 -0.62 1.84e-29 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10314221 chr15:85174505 SCAND2 -0.53 -6.31 -0.36 1.17e-9 Gut microbiome composition (summer); CESC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg11764359 chr7:65958608 NA -0.79 -12.03 -0.59 6.79e-27 Aortic root size; CESC cis rs6088580 0.634 rs4258875 chr20:32924895 C/A cg06115741 chr20:33292138 TP53INP2 -0.44 -5.65 -0.33 4.13e-8 Glomerular filtration rate (creatinine); CESC cis rs7937682 0.889 rs484013 chr11:111495779 G/A cg09085632 chr11:111637200 PPP2R1B -0.95 -14.66 -0.67 4.83e-36 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05598546 chr1:76251766 SNORD45C;RABGGTB -0.59 -7.24 -0.41 4.99e-12 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg25072359 chr17:41440525 NA 0.44 6.0 0.35 6.54e-9 Menopause (age at onset); CESC cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg15485101 chr11:133734466 NA 0.4 6.6 0.38 2.21e-10 Childhood ear infection; CESC cis rs2273669 0.667 rs75263286 chr6:109350489 G/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.06 -0.35 4.74e-9 Prostate cancer; CESC cis rs698833 0.859 rs786612 chr2:44600819 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.44 5.63 0.33 4.58e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.46 -7.79 -0.43 1.49e-13 Hemoglobin concentration; CESC cis rs151234 0.741 rs3194168 chr16:28603012 A/G cg01378222 chr16:28622494 SULT1A1 -0.57 -7.18 -0.4 7.06e-12 Platelet distribution width; CESC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg08968635 chr6:28129556 ZNF389 0.41 5.51 0.32 8.4e-8 Depression; CESC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg05368731 chr17:41323189 NBR1 0.8 11.11 0.56 8.39e-24 Menopause (age at onset); CESC cis rs6570726 0.875 rs12524077 chr6:145866333 G/C cg23711669 chr6:146136114 FBXO30 0.8 11.78 0.59 4.84e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs6032067 0.641 rs13038485 chr20:43767759 T/A cg10761708 chr20:43804764 PI3 0.55 6.12 0.35 3.4e-9 Blood protein levels; CESC trans rs13035304 0.686 rs6726681 chr2:130508316 C/G cg18827756 chr15:42130735 JMJD7-PLA2G4B;PLA2G4B -0.44 -6.91 -0.39 3.58e-11 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs1941023 0.503 rs10792269 chr11:60117126 C/T cg08716584 chr11:60157161 MS4A7 -0.5 -7.93 -0.44 6.26e-14 Congenital heart disease (maternal effect); CESC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg08736216 chr1:53307985 ZYG11A -0.35 -5.87 -0.34 1.33e-8 Monocyte count; CESC trans rs875971 0.929 rs34406470 chr7:65929956 A/G cg26939375 chr7:64535504 NA 0.47 6.0 0.35 6.6e-9 Aortic root size; CESC cis rs9398803 0.678 rs9388500 chr6:126876580 C/G cg19875578 chr6:126661172 C6orf173 0.43 5.91 0.34 1.08e-8 Male-pattern baldness; CESC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg26314531 chr2:26401878 FAM59B -0.64 -7.29 -0.41 3.48e-12 Gut microbiome composition (summer); CESC cis rs9479482 0.935 rs5017315 chr6:150333574 C/T cg25797454 chr6:150327115 RAET1K 0.26 5.14 0.3 5.27e-7 Alopecia areata; CESC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg22903471 chr2:27725779 GCKR -0.5 -7.08 -0.4 1.27e-11 Total body bone mineral density; CESC cis rs12190007 0.573 rs3006218 chr6:169868769 G/A cg15038512 chr6:170123185 PHF10 -0.54 -7.97 -0.44 4.64e-14 Obesity-related traits; CESC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg03188948 chr7:1209495 NA 0.56 6.41 0.37 6.55e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs72781680 0.848 rs56218741 chr2:23977377 A/C cg20701182 chr2:24300061 SF3B14 0.63 5.54 0.32 7.13e-8 Lymphocyte counts; CESC cis rs2735413 0.914 rs11150035 chr16:78066449 G/C cg04733911 chr16:78082701 NA -0.49 -7.7 -0.43 2.75e-13 Systolic blood pressure (alcohol consumption interaction); CESC cis rs2290159 0.800 rs5746214 chr3:12644753 A/G cg23032965 chr3:12705835 RAF1 0.52 5.69 0.33 3.27e-8 Cholesterol, total; CESC cis rs3026101 0.671 rs1806240 chr17:5298320 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs6831352 0.918 rs13143133 chr4:100054970 A/G cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs6142102 0.625 rs4911384 chr20:32555807 C/T cg08999081 chr20:33150536 PIGU 0.34 5.03 0.3 9.02e-7 Skin pigmentation; CESC trans rs10411161 0.702 rs75647161 chr19:52398984 T/C cg22319618 chr22:45562946 NUP50 -0.75 -7.3 -0.41 3.33e-12 Breast cancer; CESC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg05481257 chr2:20870211 GDF7 -0.38 -5.79 -0.33 2.02e-8 Abdominal aortic aneurysm; CESC cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg25517755 chr10:38738941 LOC399744 -0.46 -5.89 -0.34 1.17e-8 Extrinsic epigenetic age acceleration; CESC cis rs4595586 0.546 rs11609849 chr12:39258090 C/G cg26384229 chr12:38710491 ALG10B 0.69 10.45 0.54 1.25e-21 Morning vs. evening chronotype; CESC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.88 13.4 0.64 1.29e-31 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18355869 chr19:55897121 RPL28 0.63 6.98 0.39 2.41e-11 Gut microbiome composition (summer); CESC cis rs11997175 0.653 rs7005254 chr8:33641781 A/T ch.8.33884649F chr8:33765107 NA 0.54 6.74 0.38 9.86e-11 Body mass index; CESC cis rs1801251 0.778 rs709934 chr2:233733352 A/G cg08000102 chr2:233561755 GIGYF2 -0.59 -8.18 -0.45 1.19e-14 Coronary artery disease; CESC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg05564831 chr3:52568323 NT5DC2 0.45 7.11 0.4 1.06e-11 Bipolar disorder; CESC cis rs17293817 0.617 rs36024747 chr10:1410594 G/C cg04271617 chr10:1416546 ADARB2 0.33 5.05 0.3 8.13e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs5758659 0.714 rs5758589 chr22:42518382 A/G cg15557168 chr22:42548783 NA 0.42 6.46 0.37 4.94e-10 Cognitive function; CESC cis rs9549260 0.755 rs9577091 chr13:41227865 G/A cg21288729 chr13:41239152 FOXO1 0.65 8.51 0.46 1.27e-15 Red blood cell count; CESC cis rs3859192 0.599 rs34342173 chr17:38161507 T/C cg17467752 chr17:38218738 THRA -0.44 -5.86 -0.34 1.37e-8 White blood cell count; CESC cis rs79976124 0.837 rs11751145 chr6:66642039 T/C cg07460842 chr6:66804631 NA 0.69 8.25 0.45 7.48e-15 Type 2 diabetes; CESC cis rs5758659 0.716 rs2143138 chr22:42618340 T/C cg00645731 chr22:42541494 CYP2D7P1 -0.31 -5.35 -0.31 1.92e-7 Cognitive function; CESC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg09359103 chr1:154839909 KCNN3 -0.65 -12.23 -0.6 1.46e-27 Prostate cancer; CESC cis rs7809950 0.953 rs3094383 chr7:107143164 G/A cg23024343 chr7:107201750 COG5 -0.43 -6.08 -0.35 4.11e-9 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26807261 chr1:202857904 RABIF 0.54 6.07 0.35 4.32e-9 Gut microbiome composition (summer); CESC cis rs1448094 0.740 rs4919774 chr12:86337560 G/T cg02569458 chr12:86230093 RASSF9 0.45 6.34 0.36 9.64e-10 Major depressive disorder; CESC cis rs10779751 0.686 rs1148478 chr1:11174067 A/T cg08854313 chr1:11322531 MTOR 0.73 8.67 0.47 4.47e-16 Body mass index; CESC cis rs2952156 0.920 rs2934953 chr17:37832315 T/A cg00129232 chr17:37814104 STARD3 -0.71 -9.35 -0.5 3.86e-18 Asthma; CESC cis rs17655565 1.000 rs17126640 chr12:52704991 C/T cg08257133 chr12:52711352 KRT83 0.49 6.06 0.35 4.57e-9 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs3026101 0.671 rs62072674 chr17:5317806 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.22 0.31 3.64e-7 Body mass index; CESC cis rs2652834 1.000 rs7182618 chr15:63398622 T/C cg05507819 chr15:63340323 TPM1 0.57 5.26 0.31 2.95e-7 HDL cholesterol; CESC cis rs9287719 0.967 rs6759100 chr2:10746710 A/G cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC cis rs9303401 0.659 rs8074016 chr17:56840587 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.96 12.11 0.6 3.74e-27 Cognitive test performance; CESC cis rs2180341 1.000 rs6903878 chr6:127638600 C/G cg27446573 chr6:127587934 RNF146 1.09 16.38 0.71 3.79e-42 Breast cancer; CESC cis rs1790761 0.692 rs1148883 chr11:67304686 A/G cg00290607 chr11:67383545 NA 0.4 5.76 0.33 2.36e-8 Mean corpuscular volume; CESC cis rs11785400 0.793 rs9297972 chr8:143723660 C/T cg10596483 chr8:143751796 JRK 0.42 5.36 0.31 1.84e-7 Schizophrenia; CESC cis rs9894429 0.789 rs35887231 chr17:79587126 G/A cg18240062 chr17:79603768 NPLOC4 0.89 13.21 0.63 6.03e-31 Eye color traits; CESC cis rs2463822 0.583 rs72919462 chr11:62035663 G/A cg06239285 chr11:62104954 ASRGL1 -1.03 -8.34 -0.46 4.02e-15 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9790314 0.560 rs1450521 chr3:161091237 C/A cg03342759 chr3:160939853 NMD3 -0.41 -5.73 -0.33 2.72e-8 Morning vs. evening chronotype; CESC cis rs9611565 0.506 rs2024567 chr22:41699206 G/C cg03806693 chr22:41940476 POLR3H -0.78 -8.92 -0.48 7.96e-17 Vitiligo; CESC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg00684032 chr4:1343700 KIAA1530 0.4 5.56 0.32 6.51e-8 Obesity-related traits; CESC cis rs12701220 0.817 rs1058729 chr7:1087283 C/T cg26769984 chr7:1090371 C7orf50 0.58 6.91 0.39 3.68e-11 Bronchopulmonary dysplasia; CESC trans rs17685 0.753 rs4732595 chr7:75755139 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 12.57 0.61 1e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs939658 0.805 rs12902831 chr15:79433171 G/A cg17916960 chr15:79447300 NA -0.36 -5.97 -0.34 7.73e-9 Refractive error; CESC cis rs1707322 0.893 rs9919275 chr1:46441360 A/C cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs55728055 0.661 rs41302569 chr22:32046953 C/A cg01338084 chr22:32026380 PISD 1.26 8.24 0.45 8.13e-15 Age-related hearing impairment; CESC cis rs5747327 0.809 rs4819623 chr22:18208641 G/A cg19898043 chr22:18121309 BCL2L13 -0.4 -5.12 -0.3 6e-7 Myeloid white cell count;Granulocyte count; CESC cis rs7089973 0.872 rs11818114 chr10:116634878 G/C cg25233709 chr10:116636983 FAM160B1 0.34 5.03 0.3 9.07e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2404602 0.692 rs7174673 chr15:77071998 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs2425143 1.000 rs2378409 chr20:34392464 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.93 0.34 9.19e-9 Blood protein levels; CESC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg05564831 chr3:52568323 NT5DC2 0.44 6.9 0.39 3.9e-11 Electroencephalogram traits; CESC trans rs7618501 1.000 rs6785549 chr3:49736565 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.34 -0.46 4.21e-15 Intelligence (multi-trait analysis); CESC cis rs2070488 0.965 rs1046048 chr3:38524742 C/T cg24069376 chr3:38537580 EXOG 0.49 9.02 0.48 3.79e-17 Electrocardiographic conduction measures; CESC cis rs11112613 0.713 rs12580741 chr12:105941328 A/G cg03607813 chr12:105948248 NA -0.57 -6.87 -0.39 4.51e-11 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs1018836 0.608 rs6986165 chr8:91477062 C/G cg16814680 chr8:91681699 NA -0.57 -7.83 -0.43 1.17e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1881797 0.932 rs41305741 chr1:247689543 A/G cg18198730 chr1:247681584 NA 0.59 7.77 0.43 1.76e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs1577917 1.000 rs12664335 chr6:86597774 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.49 6.53 0.37 3.42e-10 Response to antipsychotic treatment; CESC cis rs7927771 0.524 rs7933896 chr11:47882782 C/T cg20307385 chr11:47447363 PSMC3 0.63 8.84 0.48 1.39e-16 Subjective well-being; CESC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg27532560 chr4:187881888 NA -0.4 -6.08 -0.35 4.1e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.72 0.38 1.09e-10 Prudent dietary pattern; CESC cis rs9457247 0.846 rs2757052 chr6:167380174 T/C cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.62e-7 Crohn's disease; CESC cis rs7872515 0.536 rs4302907 chr9:94774086 T/C cg01248375 chr9:94877805 SPTLC1 0.61 5.31 0.31 2.38e-7 Bipolar disorder and schizophrenia; CESC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.61 6.89 0.39 3.99e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10870270 1.000 rs10870270 chr10:133754334 G/A cg17892150 chr10:133769511 PPP2R2D -0.85 -12.55 -0.61 1.19e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs4423214 0.879 rs1792281 chr11:71135496 G/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.34 -0.41 2.58e-12 Vitamin D levels; CESC cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg24296786 chr1:45957014 TESK2 0.63 8.23 0.45 8.37e-15 High light scatter reticulocyte count; CESC cis rs17376456 0.877 rs2085960 chr5:93399934 A/G cg25358565 chr5:93447407 FAM172A 1.11 10.74 0.55 1.41e-22 Diabetic retinopathy; CESC cis rs6543140 0.964 rs6543144 chr2:103092575 A/G cg04239558 chr2:103089729 SLC9A4 0.5 6.43 0.37 5.76e-10 Blood protein levels; CESC cis rs916888 0.610 rs142167 chr17:44795234 C/T cg17911788 chr17:44343683 NA 0.44 6.89 0.39 4.07e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07520141 chr5:10564205 ANKRD33B 0.48 6.52 0.37 3.44e-10 Systemic lupus erythematosus; CESC trans rs1005277 0.579 rs2749616 chr10:38510993 A/T cg27523141 chr10:43048294 ZNF37B 0.46 6.02 0.35 5.91e-9 Extrinsic epigenetic age acceleration; CESC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.55 -6.96 -0.39 2.68e-11 Prudent dietary pattern; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg22824265 chr14:39901331 FBXO33 -0.48 -6.17 -0.35 2.52e-9 Asthma; CESC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg12373951 chr3:133503437 NA 0.53 7.59 0.42 5.4e-13 Iron status biomarkers; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09348431 chr8:144898112 SCRIB -0.48 -6.76 -0.38 8.53e-11 Fibrinogen levels; CESC cis rs5769765 0.955 rs7511159 chr22:50307896 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.48 -5.42 -0.32 1.35e-7 Schizophrenia; CESC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg18099408 chr3:52552593 STAB1 -0.35 -5.94 -0.34 8.7e-9 Electroencephalogram traits; CESC cis rs56399783 0.901 rs7803944 chr7:2809087 G/A cg19731401 chr7:2775893 GNA12 0.63 5.69 0.33 3.39e-8 Childhood ear infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15919258 chr14:90849921 NA -0.73 -8.86 -0.48 1.18e-16 Gut microbiome composition (summer); CESC trans rs2109514 0.505 rs1633714 chr7:116022538 C/T cg19981660 chr12:132434166 EP400 0.45 6.01 0.35 6.02e-9 Prevalent atrial fibrillation; CESC cis rs1878931 0.501 rs37800 chr16:3423648 T/G cg22508957 chr16:3507546 NAT15 0.38 5.46 0.32 1.09e-7 Body mass index (adult); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27426447 chr16:83947913 MLYCD -0.55 -6.11 -0.35 3.48e-9 Gut microbiome composition (summer); CESC cis rs6087990 0.568 rs853854 chr20:31420757 T/A cg13636640 chr20:31349939 DNMT3B 0.74 11.29 0.57 2.18e-24 Ulcerative colitis; CESC cis rs9581857 0.579 rs76657892 chr13:27997604 A/G cg01674679 chr13:27998804 GTF3A -0.67 -5.63 -0.33 4.51e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs2243480 1.000 rs451396 chr7:65484074 T/A cg25894440 chr7:65020034 NA -0.65 -5.63 -0.33 4.5e-8 Diabetic kidney disease; CESC cis rs6674176 0.542 rs2906468 chr1:44319007 A/G cg12908607 chr1:44402522 ARTN -0.4 -5.49 -0.32 9.61e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4835473 0.897 rs4835119 chr4:144903363 G/C cg25736465 chr4:144833511 NA 0.4 6.12 0.35 3.42e-9 Immature fraction of reticulocytes; CESC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg09177884 chr7:1199841 ZFAND2A -0.69 -9.75 -0.51 2.12e-19 Longevity;Endometriosis; CESC cis rs2425143 1.000 rs8116836 chr20:34453362 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.74 -6.98 -0.39 2.3e-11 Blood protein levels; CESC cis rs763121 0.853 rs5750626 chr22:38977890 G/C cg14440974 chr22:39074834 NA -0.4 -5.26 -0.31 2.98e-7 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12271800 chr19:59028764 ZBTB45 -0.62 -7.17 -0.4 7.67e-12 Gut microbiome composition (summer); CESC cis rs4664308 0.618 rs6722275 chr2:160893260 C/T cg03641300 chr2:160917029 PLA2R1 -0.59 -8.51 -0.46 1.33e-15 Idiopathic membranous nephropathy; CESC cis rs7809950 1.000 rs4730245 chr7:107087294 C/T cg23024343 chr7:107201750 COG5 -0.42 -5.91 -0.34 1.06e-8 Coronary artery disease; CESC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg17376030 chr22:41985996 PMM1 0.77 7.96 0.44 4.91e-14 Vitiligo; CESC trans rs11098499 0.954 rs12499324 chr4:120393786 C/T cg25214090 chr10:38739885 LOC399744 0.71 10.23 0.53 6.54e-21 Corneal astigmatism; CESC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg18850127 chr7:39170497 POU6F2 0.37 5.15 0.3 4.98e-7 IgG glycosylation; CESC cis rs9457247 0.935 rs401260 chr6:167405888 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.89 0.34 1.15e-8 Crohn's disease; CESC cis rs4148883 0.689 rs1154415 chr4:99999033 T/C cg12011299 chr4:100065546 ADH4 0.61 8.78 0.47 2.02e-16 Alcohol dependence; CESC cis rs7607369 0.609 rs13391398 chr2:219282429 A/G cg02176678 chr2:219576539 TTLL4 0.34 5.53 0.32 7.73e-8 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs9329289 0.510 rs12359941 chr10:2547015 G/A cg15501526 chr10:2543763 NA 0.49 7.99 0.44 4.12e-14 Age-related hearing impairment; CESC cis rs6693567 0.565 rs1313570 chr1:150342642 T/C cg09579323 chr1:150459698 TARS2 0.46 6.05 0.35 4.93e-9 Migraine; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07404466 chr20:56064128 HMGB1L1 -0.59 -7.24 -0.41 4.76e-12 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg00166722 chr3:10149974 C3orf24 0.52 6.38 0.36 7.91e-10 Alzheimer's disease; CESC cis rs9929218 0.817 rs3114400 chr16:68719430 C/T cg02972257 chr16:68554789 NA 0.56 6.36 0.36 8.69e-10 Colorectal cancer; CESC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg18099408 chr3:52552593 STAB1 -0.3 -5.04 -0.3 8.71e-7 Bipolar disorder; CESC cis rs9329289 1.000 rs9329289 chr10:2542389 A/G cg18171855 chr10:2543474 NA 0.36 5.7 0.33 3.12e-8 Age-related hearing impairment; CESC cis rs11758351 0.660 rs16891443 chr6:26221937 A/C cg01420254 chr6:26195488 NA 0.77 8.49 0.46 1.48e-15 Gout;Renal underexcretion gout; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14995492 chr5:122971951 NA -0.45 -6.02 -0.35 5.84e-9 Gut microbiome composition (summer); CESC cis rs2130392 1.000 rs873686 chr4:185638876 A/G cg21366198 chr4:185655624 MLF1IP 0.47 6.33 0.36 1.05e-9 Kawasaki disease; CESC cis rs11098499 1.000 rs1011054 chr4:120202387 A/G cg24375607 chr4:120327624 NA -0.44 -5.23 -0.31 3.41e-7 Corneal astigmatism; CESC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.515 rs13118898 chr4:98792893 T/A cg05340658 chr4:99064831 C4orf37 0.58 7.25 0.41 4.5e-12 Colonoscopy-negative controls vs population controls; CESC cis rs11153306 0.818 rs1476043 chr6:111944979 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.4 -6.09 -0.35 3.87e-9 Tonsillectomy; CESC cis rs2243480 0.908 rs1532573 chr7:65798802 A/G cg12463550 chr7:65579703 CRCP -0.73 -5.71 -0.33 3.01e-8 Diabetic kidney disease; CESC cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 7.22 0.41 5.52e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg12463550 chr7:65579703 CRCP -0.52 -6.62 -0.38 1.94e-10 Aortic root size; CESC trans rs561341 0.941 rs550213 chr17:30317518 C/G cg20587970 chr11:113659929 NA -1.1 -13.92 -0.65 1.93e-33 Hip circumference adjusted for BMI; CESC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg04248312 chr19:17393744 ANKLE1 0.94 15.09 0.68 1.46e-37 Systemic lupus erythematosus; CESC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg18402987 chr7:1209562 NA 0.81 8.43 0.46 2.27e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4566357 0.595 rs6707159 chr2:227909339 T/A cg11843606 chr2:227700838 RHBDD1 -0.49 -6.64 -0.38 1.73e-10 Coronary artery disease; CESC trans rs11098499 0.789 rs9991166 chr4:120237851 G/A cg25214090 chr10:38739885 LOC399744 0.61 8.51 0.46 1.33e-15 Corneal astigmatism; CESC cis rs12950390 0.853 rs10445375 chr17:45864314 C/T cg00777063 chr17:45855553 NA 0.37 5.5 0.32 9.02e-8 IgG glycosylation; CESC cis rs965469 0.724 rs2007022 chr20:3237674 C/A cg25506879 chr20:3388711 C20orf194 -0.51 -5.57 -0.32 6.1e-8 IFN-related cytopenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09681706 chr7:75703103 NA -0.57 -6.13 -0.35 3.17e-9 Gut microbiome composition (summer); CESC cis rs10028773 0.666 rs35231872 chr4:120248376 A/T cg09307838 chr4:120376055 NA 0.74 9.42 0.5 2.28e-18 Educational attainment; CESC cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg26818010 chr10:134567672 INPP5A -0.81 -10.03 -0.52 2.81e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg16743903 chr16:89593216 SPG7 -0.43 -5.62 -0.33 4.73e-8 Multiple myeloma (IgH translocation); CESC cis rs1552244 0.748 rs9862221 chr3:10059658 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 10.26 0.53 5.28e-21 Alzheimer's disease; CESC cis rs7116495 0.609 rs7113520 chr11:71691946 G/A cg10381502 chr11:71823885 C11orf51 -1.17 -7.41 -0.41 1.74e-12 Severe influenza A (H1N1) infection; CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg23978390 chr7:1156363 C7orf50 0.54 7.42 0.41 1.61e-12 Longevity;Endometriosis; CESC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.69 0.64 1.29e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs820218 0.926 rs820209 chr17:73649954 C/G cg01592526 chr17:73663357 RECQL5;SAP30BP 0.4 5.34 0.31 2.04e-7 Rotator cuff tears; CESC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg26338869 chr17:61819248 STRADA 0.69 9.2 0.49 1.1e-17 Prudent dietary pattern; CESC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg07507251 chr3:52567010 NT5DC2 -0.36 -6.51 -0.37 3.84e-10 Electroencephalogram traits; CESC cis rs4566357 0.615 rs1800517 chr2:227915832 G/A cg05526886 chr2:227700861 RHBDD1 -0.5 -6.54 -0.37 3.14e-10 Coronary artery disease; CESC cis rs796364 0.570 rs4673491 chr2:200669108 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.62 5.29 0.31 2.52e-7 Schizophrenia; CESC cis rs10129255 0.912 rs35468694 chr14:107192436 A/C cg23076370 chr14:107095027 NA -0.47 -5.92 -0.34 9.93e-9 Kawasaki disease; CESC cis rs1729951 0.575 rs2163896 chr3:136691177 G/A cg25687071 chr3:136751404 NA 0.39 5.19 0.3 4.27e-7 Neuroticism; CESC cis rs7927771 0.524 rs4752865 chr11:47759841 G/A cg20307385 chr11:47447363 PSMC3 -0.58 -8.05 -0.44 2.77e-14 Subjective well-being; CESC cis rs963731 0.649 rs378698 chr2:39316301 T/C cg04010122 chr2:39346883 SOS1 -0.74 -5.39 -0.31 1.54e-7 Corticobasal degeneration; CESC cis rs116095464 0.867 rs7726582 chr5:215349 C/G cg22857025 chr5:266934 NA -1.25 -17.87 -0.74 2.1e-47 Breast cancer; CESC cis rs34286592 1.000 rs7201519 chr16:29859977 A/G cg27338089 chr16:29820515 MAZ 0.48 5.04 0.3 8.68e-7 Multiple sclerosis; CESC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.74 0.38 9.58e-11 Bipolar disorder; CESC cis rs9796 0.621 rs28737302 chr15:41469943 G/A cg18705301 chr15:41695430 NDUFAF1 -0.44 -6.44 -0.37 5.52e-10 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06057141 chr7:45026417 SNORA9;C7orf40 0.39 6.03 0.35 5.54e-9 Gambling; CESC cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg15017067 chr4:17643749 FAM184B 0.41 5.9 0.34 1.12e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg24549020 chr5:56110836 MAP3K1 -0.54 -5.88 -0.34 1.2e-8 Initial pursuit acceleration; CESC cis rs7481584 0.624 rs451060 chr11:3056389 G/A cg08508325 chr11:3079039 CARS 0.29 5.15 0.3 5.15e-7 Calcium levels; CESC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg06634786 chr22:41940651 POLR3H 0.68 6.72 0.38 1.13e-10 Vitiligo; CESC cis rs9291683 0.595 rs13150928 chr4:10052961 G/T cg11266682 chr4:10021025 SLC2A9 0.68 13.68 0.64 1.38e-32 Bone mineral density; CESC cis rs6740322 0.748 rs6727631 chr2:43470408 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.77 -8.36 -0.46 3.56e-15 Coronary artery disease; CESC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg24768116 chr2:27665128 KRTCAP3 0.31 5.92 0.34 9.98e-9 Total body bone mineral density; CESC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg18301423 chr5:131593218 PDLIM4 0.41 5.96 0.34 8e-9 Acylcarnitine levels; CESC cis rs9457247 0.579 rs2181059 chr6:167441624 T/C cg25258033 chr6:167368657 RNASET2 0.37 5.4 0.31 1.51e-7 Crohn's disease; CESC cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg24733560 chr20:60626293 TAF4 0.48 7.2 0.4 6.09e-12 Body mass index; CESC cis rs10927875 0.632 rs6699394 chr1:16145143 C/A cg21385522 chr1:16154831 NA -1.01 -16.43 -0.71 2.59e-42 Dilated cardiomyopathy; CESC trans rs5769765 0.773 rs9616382 chr22:50312979 C/T cg09872104 chr7:134855509 C7orf49 -0.55 -6.31 -0.36 1.19e-9 Schizophrenia; CESC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg02935154 chr7:12443704 VWDE -0.59 -6.31 -0.36 1.14e-9 Coronary artery disease; CESC cis rs3733585 0.699 rs2018643 chr4:9947121 C/T cg02734326 chr4:10020555 SLC2A9 0.4 5.61 0.33 5.2e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs17401966 1.000 rs58549151 chr1:10314657 A/C cg15208524 chr1:10270712 KIF1B 0.5 6.47 0.37 4.65e-10 Hepatocellular carcinoma; CESC cis rs782590 0.694 rs2627775 chr2:55877113 C/T cg18811423 chr2:55921094 PNPT1 0.71 10.47 0.54 1.06e-21 Metabolic syndrome; CESC cis rs6674176 0.628 rs3791119 chr1:44431362 C/G cg12908607 chr1:44402522 ARTN -0.49 -6.93 -0.39 3.18e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg11890956 chr21:40555474 PSMG1 -0.6 -8.25 -0.45 7.41e-15 Menarche (age at onset); CESC cis rs7395581 0.918 rs7124955 chr11:47315274 A/T cg25783544 chr11:47291846 MADD 0.59 7.61 0.42 4.89e-13 HDL cholesterol; CESC cis rs4654899 0.895 rs10916865 chr1:21136610 C/T cg05370193 chr1:21551575 ECE1 -0.35 -5.05 -0.3 8.17e-7 Superior frontal gyrus grey matter volume; CESC cis rs728616 0.510 rs35671072 chr10:82172255 A/G cg05935833 chr10:81318306 SFTPA2 -0.41 -5.2 -0.3 4.04e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9916302 0.904 rs4357971 chr17:37717280 C/T cg00129232 chr17:37814104 STARD3 -0.57 -7.46 -0.42 1.22e-12 Glomerular filtration rate (creatinine); CESC cis rs6546550 0.901 rs11126251 chr2:70163434 A/C cg02498382 chr2:70120550 SNRNP27 -0.41 -7.12 -0.4 1.04e-11 Prevalent atrial fibrillation; CESC cis rs2797160 1.000 rs2797154 chr6:126005197 A/G cg05901451 chr6:126070800 HEY2 -0.45 -6.53 -0.37 3.43e-10 Endometrial cancer; CESC cis rs1552244 0.554 rs3732963 chr3:10048885 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 7.95 0.44 5.32e-14 Alzheimer's disease; CESC cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg19077165 chr18:44547161 KATNAL2 0.54 8.01 0.44 3.56e-14 Personality dimensions; CESC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg11764359 chr7:65958608 NA -0.8 -11.89 -0.59 2.01e-26 Aortic root size; CESC trans rs10518765 1.000 rs67810220 chr15:54673819 A/T cg09098624 chr8:11558334 NA -0.56 -6.02 -0.35 5.75e-9 Select biomarker traits; CESC cis rs2243480 1.000 rs2257790 chr7:65600450 C/T cg18252515 chr7:66147081 NA -1.34 -13.39 -0.64 1.45e-31 Diabetic kidney disease; CESC trans rs7980799 0.649 rs2389218 chr12:33680929 C/A cg26384229 chr12:38710491 ALG10B 0.57 8.03 0.44 3.14e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs1801251 1.000 rs6437074 chr2:233712296 C/T cg08000102 chr2:233561755 GIGYF2 -0.68 -9.69 -0.51 3.29e-19 Coronary artery disease; CESC cis rs9911578 0.934 rs58092632 chr17:57111101 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.04 -0.3 8.43e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04072768 chr2:54683502 SPTBN1 0.52 6.18 0.35 2.36e-9 Gut microbiome composition (summer); CESC cis rs2070488 0.766 rs6808093 chr3:38498160 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 12.54 0.61 1.2e-28 Electrocardiographic conduction measures; CESC cis rs9314323 0.798 rs12682345 chr8:26218332 A/G cg11498726 chr8:26250323 BNIP3L 0.44 6.36 0.36 8.65e-10 Red cell distribution width; CESC cis rs614226 0.938 rs7963543 chr12:120923948 C/A cg01236616 chr12:121019343 POP5 1.45 17.93 0.74 1.25e-47 Type 1 diabetes nephropathy; CESC cis rs1670533 1.000 rs4690212 chr4:1054898 T/C cg27284194 chr4:1044797 NA 0.48 6.06 0.35 4.7e-9 Recombination rate (females); CESC cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg02773041 chr1:40204384 PPIE -0.51 -7.1 -0.4 1.14e-11 Blood protein levels; CESC cis rs9303401 0.659 rs7223708 chr17:56896398 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.5 0.61 1.71e-28 Cognitive test performance; CESC cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.07 0.3 7.33e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.694 rs5758389 chr22:41941749 T/C cg03806693 chr22:41940476 POLR3H -0.87 -11.03 -0.56 1.53e-23 Vitiligo; CESC cis rs9581857 0.547 rs4612914 chr13:28049128 A/G cg22138327 chr13:27999177 GTF3A 0.63 5.12 0.3 5.88e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs6504663 0.596 rs7208018 chr17:48557863 C/T cg03611598 chr17:48586076 MYCBPAP -0.52 -6.05 -0.35 4.83e-9 Visceral fat; CESC cis rs6088580 0.634 rs6142164 chr20:33006597 C/T cg06115741 chr20:33292138 TP53INP2 -0.47 -6.02 -0.35 5.66e-9 Glomerular filtration rate (creatinine); CESC trans rs814141 1.000 rs9559427 chr13:109512417 C/T cg06824394 chr7:86846535 C7orf23 -0.63 -6.1 -0.35 3.68e-9 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CESC cis rs6912958 0.712 rs4707383 chr6:88330602 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.38 -0.31 1.67e-7 Monocyte percentage of white cells; CESC cis rs2204008 0.806 rs11520229 chr12:38246448 C/A cg26384229 chr12:38710491 ALG10B 0.71 10.11 0.53 1.52e-20 Bladder cancer; CESC cis rs3820928 0.874 rs10177995 chr2:227781600 T/C cg11843606 chr2:227700838 RHBDD1 -0.49 -6.59 -0.38 2.33e-10 Pulmonary function; CESC cis rs13242816 1.000 rs56298491 chr7:116116687 C/T cg04696780 chr7:116139425 CAV2 -0.58 -5.16 -0.3 4.76e-7 P wave duration; CESC cis rs1800469 1.000 rs1800469 chr19:41860296 A/G cg09537434 chr19:41945824 ATP5SL -0.7 -8.54 -0.46 1.03e-15 Colorectal cancer; CESC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg06028605 chr16:24865363 SLC5A11 0.55 7.81 0.43 1.34e-13 Intelligence (multi-trait analysis); CESC cis rs7134594 0.677 rs2075432 chr12:109874230 A/G cg19025524 chr12:109796872 NA -0.39 -5.66 -0.33 3.88e-8 HDL cholesterol; CESC trans rs7077164 0.607 rs1227771 chr10:71577902 C/T cg01481902 chr6:167791153 TCP10 -0.38 -6.11 -0.35 3.52e-9 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs999943 0.774 rs12205634 chr6:33611667 C/G cg14003231 chr6:33640908 ITPR3 0.74 13.79 0.65 5.63e-33 Obesity (extreme); CESC cis rs1707322 1.000 rs12077974 chr1:46384141 G/A cg03146154 chr1:46216737 IPP 0.69 8.99 0.48 4.88e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg11494091 chr17:61959527 GH2 0.72 12.39 0.61 4.12e-28 Prudent dietary pattern; CESC cis rs9815354 0.767 rs73069245 chr3:41951452 G/A cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.9e-9 Pulse pressure;Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12381575 chr19:36485972 SDHAF1 -0.67 -7.68 -0.43 2.99e-13 Gut microbiome composition (summer); CESC cis rs62229266 0.563 rs6517325 chr21:37434978 T/C cg12218747 chr21:37451666 NA -0.37 -5.09 -0.3 6.84e-7 Mitral valve prolapse; CESC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg09877947 chr5:131593287 PDLIM4 0.46 5.96 0.34 8.2e-9 Breast cancer; CESC cis rs11122272 0.735 rs10489611 chr1:231517854 A/T cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs9400271 0.632 rs9400262 chr6:109591433 T/C cg01475377 chr6:109611718 NA -0.46 -7.18 -0.4 7.24e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg26818010 chr10:134567672 INPP5A -0.8 -9.99 -0.52 3.86e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2573652 1.000 rs1469828 chr15:100517210 A/C cg00587665 chr15:100533223 ADAMTS17 -0.35 -5.53 -0.32 7.83e-8 Height; CESC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg16325326 chr1:53192061 ZYG11B 0.89 14.59 0.67 8.76e-36 Monocyte count; CESC cis rs6912958 0.678 rs9450744 chr6:88280529 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.58 -0.37 2.55e-10 Monocyte percentage of white cells; CESC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg01988459 chr11:68622903 NA -0.39 -5.21 -0.3 3.76e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1355223 1.000 rs1355221 chr11:34758609 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.35 -0.36 9.2e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.25 0.41 4.65e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3733585 0.673 rs4455410 chr4:9953297 C/T cg11266682 chr4:10021025 SLC2A9 0.57 10.62 0.55 3.48e-22 Cleft plate (environmental tobacco smoke interaction); CESC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg09177884 chr7:1199841 ZFAND2A -0.52 -6.73 -0.38 1.06e-10 Longevity;Endometriosis; CESC cis rs4704187 0.687 rs6889372 chr5:74531150 A/T cg03227963 chr5:74354835 NA 0.28 5.17 0.3 4.61e-7 Response to amphetamines; CESC cis rs3806843 0.741 rs2563293 chr5:140110536 T/C cg16179182 chr5:140090404 VTRNA1-1 0.44 5.77 0.33 2.25e-8 Depressive symptoms (multi-trait analysis); CESC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg00934597 chr7:893267 UNC84A -0.49 -6.68 -0.38 1.39e-10 Perceived unattractiveness to mosquitoes; CESC cis rs9911578 0.757 rs4793954 chr17:56629527 G/T cg12560992 chr17:57184187 TRIM37 -0.88 -11.4 -0.57 9.56e-25 Intelligence (multi-trait analysis); CESC cis rs2732480 0.538 rs2468943 chr12:48747249 G/T cg04545296 chr12:48745243 ZNF641 -0.35 -5.78 -0.33 2.04e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs10851478 0.872 rs12591317 chr15:49945675 A/G cg08060515 chr15:49448048 GALK2;COPS2 0.43 5.29 0.31 2.52e-7 Oral cavity cancer; CESC cis rs2180341 0.961 rs7774468 chr6:127592501 G/C cg27446573 chr6:127587934 RNF146 1.07 15.89 0.7 2.11e-40 Breast cancer; CESC cis rs7552167 0.925 rs4489498 chr1:24512055 A/G cg01960748 chr1:24522592 NA 0.46 6.58 0.37 2.5e-10 Psoriasis vulgaris; CESC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 13.14 0.63 1.07e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg05564831 chr3:52568323 NT5DC2 0.46 7.29 0.41 3.58e-12 Bipolar disorder; CESC cis rs4867766 0.585 rs6878032 chr5:173950070 A/G cg20434911 chr5:173954559 NA 0.55 5.04 0.3 8.66e-7 Stroke; CESC cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg24818145 chr4:99064322 C4orf37 0.39 5.1 0.3 6.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2288327 0.643 rs16866334 chr2:179336672 A/G cg11548914 chr2:179343871 FKBP7;PLEKHA3;MIR548N 0.54 5.83 0.34 1.65e-8 Atrial fibrillation; CESC cis rs11098499 0.863 rs10034450 chr4:120455649 A/G cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs9911578 0.935 rs9911753 chr17:56983174 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.29 0.31 2.52e-7 Intelligence (multi-trait analysis); CESC cis rs5769765 0.704 rs138837 chr22:50180714 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.46 -5.14 -0.3 5.34e-7 Schizophrenia; CESC cis rs4423214 1.000 rs4944955 chr11:71167677 C/T cg05163923 chr11:71159392 DHCR7 0.84 11.56 0.58 2.73e-25 Vitamin D levels; CESC cis rs2120019 1.000 rs2083731 chr15:75368538 A/C cg17294928 chr15:75287854 SCAMP5 -0.59 -6.62 -0.38 1.97e-10 Blood trace element (Zn levels); CESC cis rs7223966 1.000 rs9747164 chr17:61864787 T/C cg11494091 chr17:61959527 GH2 0.38 5.06 0.3 7.94e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7772486 0.686 rs1004752 chr6:146037822 G/A cg23711669 chr6:146136114 FBXO30 -0.87 -12.9 -0.62 7e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs34375054 0.724 rs4517581 chr12:125667394 A/G cg25124228 chr12:125621409 AACS -0.46 -5.25 -0.31 3.08e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs1568889 1.000 rs12802157 chr11:28060285 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.96 0.56 2.77e-23 Bipolar disorder; CESC cis rs9905704 0.647 rs8077332 chr17:57105223 A/G cg12560992 chr17:57184187 TRIM37 0.62 7.7 0.43 2.69e-13 Testicular germ cell tumor; CESC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg10691866 chr7:65817282 TPST1 -0.33 -5.39 -0.31 1.58e-7 Aortic root size; CESC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg13206674 chr6:150067644 NUP43 0.42 5.89 0.34 1.19e-8 Lung cancer; CESC cis rs617791 0.530 rs735942 chr11:65749337 A/G cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.15 -0.3 5.05e-7 Breast cancer; CESC cis rs73001065 0.901 rs739846 chr19:19419071 G/A cg03709012 chr19:19516395 GATAD2A 0.92 6.15 0.35 2.82e-9 LDL cholesterol; CESC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg06420487 chr17:61919686 SMARCD2 0.43 5.24 0.31 3.26e-7 Height; CESC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg19445457 chr11:5799446 OR52N5 -0.39 -5.12 -0.3 5.77e-7 DNA methylation (variation); CESC cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg15485101 chr11:133734466 NA 0.41 6.63 0.38 1.85e-10 Childhood ear infection; CESC cis rs11112613 0.713 rs12307351 chr12:105955634 T/A cg03607813 chr12:105948248 NA 0.57 6.39 0.37 7.59e-10 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.45 -5.91 -0.34 1.02e-8 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs6951245 0.810 rs117800627 chr7:1081075 G/C cg18402987 chr7:1209562 NA 0.71 7.16 0.4 7.98e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7259376 0.936 rs12151261 chr19:22587929 C/T cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.76e-7 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00699235 chr12:49962218 MCRS1 0.49 6.35 0.36 9.1e-10 Gut microbiota (bacterial taxa); CESC cis rs10752881 0.967 rs8179361 chr1:182974572 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 13.12 0.63 1.19e-30 Colorectal cancer; CESC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg04369109 chr6:150039330 LATS1 -0.38 -5.26 -0.31 2.91e-7 Lung cancer; CESC cis rs6940638 0.688 rs1028308 chr6:27129757 G/A cg12826209 chr6:26865740 GUSBL1 0.39 5.07 0.3 7.42e-7 Intelligence (multi-trait analysis); CESC cis rs6942756 1.000 rs7803052 chr7:128959427 A/G cg02491457 chr7:128862824 NA -0.66 -8.95 -0.48 6.38e-17 White matter hyperintensity burden; CESC cis rs941873 0.805 rs8837 chr10:81114813 C/G cg08514558 chr10:81106712 PPIF 0.35 5.92 0.34 9.89e-9 Height; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07782113 chr6:12012564 HIVEP1 -0.5 -6.47 -0.37 4.76e-10 Asthma; CESC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg14983838 chr19:29218262 NA 0.5 6.16 0.35 2.67e-9 Methadone dose in opioid dependence; CESC cis rs7584330 0.910 rs6713555 chr2:238398182 A/G cg14458575 chr2:238380390 NA -0.7 -9.17 -0.49 1.38e-17 Prostate cancer; CESC cis rs698833 0.961 rs1223162 chr2:44737704 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.07 0.3 7.46e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs116095464 0.558 rs7703803 chr5:292311 A/G cg22496380 chr5:211416 CCDC127 -0.75 -8.55 -0.46 1.03e-15 Breast cancer; CESC cis rs3806843 1.000 rs2240692 chr5:140183585 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.26 -0.31 2.95e-7 Depressive symptoms (multi-trait analysis); CESC cis rs12618769 0.597 rs72819987 chr2:99046253 A/G cg10123293 chr2:99228465 UNC50 0.4 5.28 0.31 2.67e-7 Bipolar disorder; CESC cis rs11723261 0.582 rs116471062 chr4:163522 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.45 5.66 0.33 3.9e-8 Immune response to smallpox vaccine (IL-6); CESC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg00166722 chr3:10149974 C3orf24 0.48 5.92 0.34 1.01e-8 Alzheimer's disease; CESC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.75e-12 Tonsillectomy; CESC cis rs2075371 0.637 rs13245165 chr7:133951492 A/T cg11752832 chr7:134001865 SLC35B4 0.53 6.79 0.38 7.51e-11 Mean platelet volume; CESC cis rs2228479 0.850 rs17227263 chr16:89810598 G/A cg14709524 chr16:89940631 TCF25 0.94 7.08 0.4 1.27e-11 Skin colour saturation; CESC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg14983838 chr19:29218262 NA 0.48 5.7 0.33 3.26e-8 Methadone dose in opioid dependence; CESC cis rs9611565 0.649 rs139553 chr22:42187199 A/G cg06634786 chr22:41940651 POLR3H 0.45 5.08 0.3 7.27e-7 Vitiligo; CESC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.54 6.73 0.38 1.05e-10 Prudent dietary pattern; CESC cis rs8114671 0.967 rs6088747 chr20:33754604 G/T cg24642439 chr20:33292090 TP53INP2 0.42 5.36 0.31 1.79e-7 Height; CESC cis rs360798 0.512 rs6545973 chr2:63089434 C/T cg17519650 chr2:63277830 OTX1 0.47 5.75 0.33 2.51e-8 Coronary artery disease; CESC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg03709012 chr19:19516395 GATAD2A -0.96 -14.12 -0.66 3.81e-34 Tonsillectomy; CESC cis rs8005677 1.000 rs8006396 chr14:23380850 A/G cg01529538 chr14:23388837 RBM23 0.51 6.87 0.39 4.64e-11 Cognitive ability (multi-trait analysis); CESC cis rs10883723 0.810 rs3818470 chr10:104263675 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs7523050 0.730 rs72984612 chr1:109434826 T/C cg08274380 chr1:109419600 GPSM2 0.91 6.41 0.37 6.51e-10 Fat distribution (HIV); CESC cis rs10504229 0.953 rs114806125 chr8:58182416 C/T cg22535103 chr8:58192502 C8orf71 -0.88 -11.43 -0.57 7.29e-25 Developmental language disorder (linguistic errors); CESC cis rs12477438 0.765 rs56167745 chr2:99600478 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.91 -0.48 8.52e-17 Chronic sinus infection; CESC cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.33 0.6 6.73e-28 Colonoscopy-negative controls vs population controls; CESC cis rs6088590 0.901 rs6087631 chr20:33403509 T/C cg06115741 chr20:33292138 TP53INP2 0.6 7.37 0.41 2.11e-12 Coronary artery disease; CESC cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.1 0.3 6.4e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05309454 chr17:79791505 FAM195B;DYSFIP1 -0.49 -7.26 -0.41 4.38e-12 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11696501 0.694 rs6073827 chr20:44265556 T/C cg11783356 chr20:44313418 WFDC10B -0.33 -5.12 -0.3 5.9e-7 Brain structure; CESC cis rs9660992 0.700 rs7547565 chr1:205259402 G/A cg21643547 chr1:205240462 TMCC2 0.5 7.22 0.41 5.67e-12 Mean corpuscular volume;Mean platelet volume; CESC cis rs6835098 1.000 rs10011724 chr4:174088865 A/G cg08422745 chr4:174089978 GALNT7 -0.83 -12.26 -0.6 1.16e-27 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs4474465 0.790 rs10793325 chr11:78252575 T/C cg27205649 chr11:78285834 NARS2 0.43 5.34 0.31 2.05e-7 Alzheimer's disease (survival time); CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg17608500 chr1:154955711 FLAD1 -0.54 -6.17 -0.35 2.55e-9 Subjective well-being; CESC cis rs897080 0.515 rs698767 chr2:44576417 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.52 6.16 0.35 2.64e-9 Height; CESC cis rs10754283 0.967 rs7515375 chr1:90109854 T/C cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs662064 0.963 rs10864459 chr1:10563609 C/T cg07384165 chr1:10488281 NA 0.42 5.56 0.32 6.51e-8 Asthma; CESC cis rs921968 0.565 rs35189512 chr2:219628759 T/C cg02176678 chr2:219576539 TTLL4 -0.44 -7.59 -0.42 5.38e-13 Mean corpuscular hemoglobin concentration; CESC cis rs2637266 0.777 rs2637253 chr10:78311287 A/C cg18941641 chr10:78392320 NA -0.31 -5.73 -0.33 2.8e-8 Pulmonary function; CESC cis rs829661 0.532 rs2363073 chr2:30796008 A/C cg12454169 chr2:30669597 LCLAT1 -0.43 -5.37 -0.31 1.73e-7 Midgestational circulating levels of PBDEs (fetal genetic effect); CESC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg24060327 chr5:131705240 SLC22A5 -0.75 -10.36 -0.54 2.45e-21 Acylcarnitine levels; CESC cis rs8077577 0.671 rs4925177 chr17:18252868 C/G cg16794390 chr17:18148240 FLII 0.38 6.25 0.36 1.59e-9 Obesity-related traits; CESC cis rs796364 0.806 rs74771155 chr2:200913743 C/T cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC cis rs7202877 0.610 rs11646418 chr16:75367585 G/C cg04384234 chr16:75411784 CFDP1 -0.54 -5.59 -0.32 5.71e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs3008870 0.583 rs17497947 chr1:67457199 G/T cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -11.11 -0.56 8.58e-24 Lymphocyte percentage of white cells; CESC cis rs765787 0.530 rs12915804 chr15:45512562 T/C cg24006582 chr15:45444508 DUOX1 0.52 6.32 0.36 1.13e-9 Uric acid levels; CESC cis rs2228479 0.850 rs17226966 chr16:89825338 A/G cg04013166 chr16:89971882 TCF25 0.79 6.75 0.38 9.14e-11 Skin colour saturation; CESC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg12463550 chr7:65579703 CRCP -0.62 -7.78 -0.43 1.65e-13 Aortic root size; CESC cis rs116161686 0.500 rs76610459 chr1:210050756 T/G cg21951975 chr1:209979733 IRF6 0.56 6.37 0.36 8.42e-10 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26311208 chr1:59012484 OMA1 0.66 7.97 0.44 4.8e-14 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs9399572 chr6:146362945 T/G cg23711669 chr6:146136114 FBXO30 0.83 12.12 0.6 3.46e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs7927771 0.524 rs4752865 chr11:47759841 G/A cg18512352 chr11:47633146 NA -0.37 -5.75 -0.33 2.43e-8 Subjective well-being; CESC cis rs9902453 1.000 rs4465649 chr17:28394747 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.87 -0.44 9.18e-14 Coffee consumption (cups per day); CESC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg22549504 chr19:17448937 GTPBP3 -0.5 -5.53 -0.32 7.59e-8 Systemic lupus erythematosus; CESC cis rs7116495 0.609 rs2845860 chr11:71716661 C/T cg10381502 chr11:71823885 C11orf51 -1.13 -7.56 -0.42 6.78e-13 Severe influenza A (H1N1) infection; CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg09177884 chr7:1199841 ZFAND2A -0.69 -9.75 -0.51 2.12e-19 Longevity;Endometriosis; CESC cis rs4654899 1.000 rs6426668 chr1:21396596 T/C cg05370193 chr1:21551575 ECE1 0.39 5.84 0.34 1.55e-8 Superior frontal gyrus grey matter volume; CESC cis rs9902453 0.808 rs8069669 chr17:28239502 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.78 10.37 0.54 2.25e-21 Coffee consumption (cups per day); CESC cis rs55788414 0.932 rs9936302 chr16:81190790 C/T cg06400318 chr16:81190750 PKD1L2 -0.68 -7.57 -0.42 6.2800000000000005e-13 Left ventricular obstructive tract defect (maternal effect); CESC cis rs7178572 0.889 rs11857450 chr15:77802791 C/G cg22256960 chr15:77711686 NA 0.57 7.6 0.42 4.97e-13 Type 2 diabetes; CESC trans rs61931739 0.500 rs7306435 chr12:34482933 A/G cg26384229 chr12:38710491 ALG10B -0.7 -10.4 -0.54 1.86e-21 Morning vs. evening chronotype; CESC cis rs35306767 0.714 rs67205460 chr10:1090366 C/T cg26597838 chr10:835615 NA 0.63 5.98 0.34 7.22e-9 Eosinophil percentage of granulocytes; CESC cis rs9486715 0.867 rs2499774 chr6:97006581 C/G cg06623918 chr6:96969491 KIAA0776 -0.96 -15.21 -0.68 5.36e-38 Headache; CESC cis rs9814567 1.000 rs4955555 chr3:134286427 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.05 -0.35 4.79e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs854765 0.547 rs9897761 chr17:17912011 A/T cg09796270 chr17:17721594 SREBF1 0.39 5.47 0.32 1.06e-7 Total body bone mineral density; CESC cis rs9399135 1.000 rs1014021 chr6:135334600 C/T cg22676075 chr6:135203613 NA -0.48 -6.81 -0.39 6.44e-11 Red blood cell count; CESC cis rs8067354 0.958 rs8081468 chr17:57836924 A/G cg02344993 chr17:57696989 CLTC 0.48 6.29 0.36 1.29e-9 Hemoglobin concentration; CESC cis rs7129220 0.512 rs7936409 chr11:10086260 A/C cg01453529 chr11:10209919 SBF2 -0.47 -5.27 -0.31 2.79e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg26587870 chr6:27730563 NA -0.57 -5.14 -0.3 5.29e-7 Depression; CESC cis rs9905704 0.756 rs302860 chr17:56695008 C/A cg12560992 chr17:57184187 TRIM37 0.62 7.73 0.43 2.17e-13 Testicular germ cell tumor; CESC cis rs4975709 0.569 rs2353583 chr5:1858834 G/C cg10800226 chr5:1850261 NA 0.36 5.74 0.33 2.64e-8 Cardiovascular disease risk factors; CESC cis rs1018836 0.828 rs10086462 chr8:91558089 A/G cg16814680 chr8:91681699 NA -0.64 -9.15 -0.49 1.58e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs6142102 0.625 rs4012234 chr20:32553047 T/G cg08999081 chr20:33150536 PIGU 0.34 5.1 0.3 6.63e-7 Skin pigmentation; CESC cis rs11098499 0.909 rs1809406 chr4:120377122 G/A cg09307838 chr4:120376055 NA 0.96 13.95 0.65 1.6e-33 Corneal astigmatism; CESC cis rs8067354 0.540 rs1051424 chr17:58024324 A/G cg13753209 chr17:57696993 CLTC 0.52 5.49 0.32 9.51e-8 Hemoglobin concentration; CESC cis rs7560272 0.501 rs12713789 chr2:73945600 A/G cg20560298 chr2:73613845 ALMS1 0.41 5.69 0.33 3.43e-8 Schizophrenia; CESC cis rs7208859 0.623 rs7212991 chr17:29143749 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10832963 1.000 rs4757676 chr11:18640477 C/T cg09201001 chr11:18656081 SPTY2D1 0.82 12.36 0.6 5.21e-28 Breast cancer; CESC cis rs6831352 0.877 rs28987101 chr4:100049253 T/G cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC cis rs2842992 0.714 rs2495278 chr6:160123674 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.72 9.18 0.49 1.27e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs10851478 0.500 rs10519225 chr15:49720778 G/A cg08060515 chr15:49448048 GALK2;COPS2 0.52 6.7 0.38 1.23e-10 Oral cavity cancer; CESC cis rs7827545 1.000 rs4909909 chr8:135564627 T/C cg17885191 chr8:135476712 NA 0.48 6.28 0.36 1.39e-9 Hypertension (SNP x SNP interaction); CESC cis rs7216064 0.911 rs12449442 chr17:65947640 G/A cg07042672 chr17:66097459 LOC651250 -0.54 -5.84 -0.34 1.55e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs2933343 0.951 rs789220 chr3:128592135 A/G cg25356066 chr3:128598488 ACAD9 -0.52 -6.89 -0.39 4.17e-11 IgG glycosylation; CESC cis rs9430161 0.579 rs10864486 chr1:11040979 A/G cg02454025 chr1:11042201 C1orf127 0.87 13.55 0.64 3.81e-32 Ewing sarcoma; CESC cis rs208520 0.634 rs3909071 chr6:66836947 T/C cg07460842 chr6:66804631 NA -0.97 -13.05 -0.63 2.22e-30 Exhaled nitric oxide output; CESC cis rs4474465 0.850 rs10793329 chr11:78265655 G/C cg27205649 chr11:78285834 NARS2 0.43 5.47 0.32 1.07e-7 Alzheimer's disease (survival time); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27013765 chr3:197402007 MIR922;KIAA0226 -0.56 -6.01 -0.35 6.19e-9 Gut microbiome composition (summer); CESC cis rs727505 1.000 rs6943653 chr7:124512249 G/A cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg12718519 chr1:2058417 PRKCZ 0.26 5.59 0.32 5.72e-8 Height; CESC trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -8.4 -0.46 2.72e-15 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18159230 chr1:169076004 ATP1B1 0.56 6.32 0.36 1.11e-9 Gut microbiome composition (summer); CESC cis rs7635838 0.859 rs9826803 chr3:11461863 G/A cg00170343 chr3:11313890 ATG7 0.46 6.02 0.35 5.77e-9 HDL cholesterol; CESC cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg00149659 chr3:10157352 C3orf10 1.0 11.96 0.59 1.22e-26 Alzheimer's disease; CESC cis rs7777484 0.534 rs2533888 chr7:2831083 T/C cg19717773 chr7:2847554 GNA12 -0.7 -12.08 -0.6 4.61e-27 Height; CESC cis rs854765 0.547 rs7209003 chr17:17907393 T/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.54 7.72 0.43 2.32e-13 Total body bone mineral density; CESC cis rs34779708 0.966 rs11010102 chr10:35411066 T/A cg04310649 chr10:35416472 CREM -0.55 -6.76 -0.38 8.85e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs7809950 1.000 rs4727680 chr7:107087407 T/G cg23024343 chr7:107201750 COG5 -0.41 -5.87 -0.34 1.27e-8 Coronary artery disease; CESC cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg23711669 chr6:146136114 FBXO30 -1.0 -15.54 -0.69 3.89e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs2180341 0.782 rs4897214 chr6:127723625 G/T cg24812749 chr6:127587940 RNF146 0.83 12.07 0.6 5.14e-27 Breast cancer; CESC cis rs854765 0.927 rs12943914 chr17:17980671 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.43 5.86 0.34 1.4e-8 Total body bone mineral density; CESC cis rs6460942 0.591 rs4721078 chr7:12334657 T/A cg20607287 chr7:12443886 VWDE -0.63 -6.83 -0.39 5.83e-11 Coronary artery disease; CESC cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.2 0.3 3.92e-7 Colonoscopy-negative controls vs population controls; CESC trans rs8073060 0.586 rs35542792 chr17:33903886 A/G cg19694781 chr19:47549865 TMEM160 0.71 6.81 0.39 6.34e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg06873352 chr17:61820015 STRADA 0.73 13.07 0.63 1.78e-30 Prudent dietary pattern; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21159473 chr9:15510228 PSIP1 -0.41 -6.03 -0.35 5.38e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.91 -0.52 6.75e-20 Developmental language disorder (linguistic errors); CESC cis rs926392 0.965 rs6129167 chr20:37689228 C/T cg16355469 chr20:37678765 NA -0.4 -5.17 -0.3 4.56e-7 Dialysis-related mortality; CESC trans rs561341 1.000 rs535151 chr17:30317405 C/T cg27661571 chr11:113659931 NA -0.55 -6.17 -0.35 2.52e-9 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25101327 chr2:119981142 STEAP3 0.63 7.31 0.41 3.14e-12 Gut microbiome composition (summer); CESC cis rs1008375 1.000 rs7661631 chr4:17679751 T/C cg16339924 chr4:17578868 LAP3 -0.56 -6.93 -0.39 3.14e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7772486 0.846 rs2748499 chr6:146315002 T/C cg23711669 chr6:146136114 FBXO30 0.83 12.06 0.6 5.43e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs7520050 0.807 rs3013595 chr1:46153203 G/A cg06784218 chr1:46089804 CCDC17 0.32 5.8 0.34 1.88e-8 Red blood cell count;Reticulocyte count; CESC cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg12927641 chr6:109611667 NA -0.43 -6.81 -0.39 6.43e-11 Reticulocyte fraction of red cells; CESC cis rs911555 0.504 rs8021368 chr14:104074810 G/A cg12935359 chr14:103987150 CKB -0.52 -7.55 -0.42 6.85e-13 Intelligence (multi-trait analysis); CESC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg19717773 chr7:2847554 GNA12 0.46 6.52 0.37 3.55e-10 Height; CESC cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 8.16 0.45 1.34e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg22590775 chr19:49891494 CCDC155 0.58 6.97 0.39 2.46e-11 Multiple sclerosis; CESC cis rs2050392 0.624 rs2489842 chr10:30721991 T/C cg02070205 chr10:30722105 MAP3K8 -0.47 -5.5 -0.32 8.84e-8 Inflammatory bowel disease; CESC cis rs12617721 0.874 rs3754890 chr2:99088624 C/T cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs11088226 0.681 rs9622 chr21:33951068 T/C cg09050820 chr6:167586206 TCP10L2 0.96 10.26 0.53 5.13e-21 Gastritis; CESC cis rs2072499 0.865 rs2758608 chr1:156202860 A/T cg24450063 chr1:156163899 SLC25A44 0.8 11.95 0.59 1.24e-26 Testicular germ cell tumor; CESC cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.22 0.36 1.9e-9 Hip circumference adjusted for BMI; CESC cis rs1461503 0.934 rs7121840 chr11:122845360 A/G cg27398637 chr11:122830231 C11orf63 -0.55 -8.03 -0.44 3.2e-14 Menarche (age at onset); CESC cis rs6951245 0.507 rs10227709 chr7:1180515 T/G cg03188948 chr7:1209495 NA 0.45 5.17 0.3 4.66e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9914544 0.966 rs7210746 chr17:18798593 T/C cg26378065 chr17:18585709 ZNF286B 0.46 5.7 0.33 3.25e-8 Educational attainment (years of education); CESC cis rs1348850 0.914 rs4893961 chr2:178411075 A/G cg23306229 chr2:178417860 TTC30B 0.62 7.94 0.44 5.89e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10911251 0.528 rs10911263 chr1:183115018 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 13.8 0.65 5.11e-33 Colorectal cancer; CESC trans rs1814175 0.645 rs847630 chr11:49926360 C/T cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs9303280 0.901 rs12103884 chr17:38045725 C/T cg19468946 chr17:37922297 IKZF3 -0.42 -5.63 -0.33 4.63e-8 Self-reported allergy; CESC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg25767906 chr1:53392781 SCP2 -0.42 -5.86 -0.34 1.37e-8 Monocyte count; CESC cis rs523516 0.645 rs16527 chr17:37322080 T/C cg20555674 chr17:37321631 ARL5C 0.37 6.25 0.36 1.6e-9 IgG glycosylation; CESC cis rs9303401 0.659 rs11079357 chr17:56902778 A/G cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.45 0.61 2.57e-28 Cognitive test performance; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg27138727 chr3:107150777 NA -0.47 -6.12 -0.35 3.26e-9 Height; CESC cis rs11792861 0.926 rs17628095 chr9:111889172 A/G cg05043794 chr9:111880884 C9orf5 0.38 6.07 0.35 4.37e-9 Menarche (age at onset); CESC cis rs8092503 1.000 rs12956220 chr18:52481750 A/T cg12377874 chr18:52495404 RAB27B 0.39 6.38 0.36 8.04e-10 Childhood body mass index; CESC cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg24110177 chr3:50126178 RBM5 -0.56 -7.62 -0.42 4.63e-13 Body mass index; CESC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg13628971 chr7:2884303 GNA12 0.65 8.78 0.47 2.04e-16 Height; CESC cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg23158103 chr7:148848205 ZNF398 -0.35 -5.29 -0.31 2.52e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 7.66 0.43 3.61e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg07936489 chr17:37558343 FBXL20 -0.78 -11.94 -0.59 1.45e-26 Glomerular filtration rate (creatinine); CESC cis rs9318086 0.935 rs9652081 chr13:24435510 C/T cg25267304 chr13:24462978 PCOTH;MIPEP -0.39 -5.32 -0.31 2.19e-7 Myopia (pathological); CESC cis rs116095464 0.558 rs10052012 chr5:231908 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.57 -0.47 8.98e-16 Breast cancer; CESC trans rs916888 0.610 rs199529 chr17:44837217 A/C cg22433210 chr17:43662623 NA 0.77 9.59 0.51 6.84e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1124376 1.000 rs6771941 chr3:20157077 G/T cg05072819 chr3:20081367 KAT2B 0.44 5.63 0.33 4.56e-8 Bipolar disorder and schizophrenia; CESC cis rs965513 1.000 rs1561962 chr9:100546219 C/T cg13688889 chr9:100608707 NA -0.59 -8.34 -0.46 4.03e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs12079745 0.590 rs75967403 chr1:169173497 T/G cg09363564 chr1:169337483 NME7;BLZF1 -1.1 -6.5 -0.37 3.95e-10 QT interval; CESC cis rs12971120 0.891 rs3794953 chr18:72180519 C/T cg26446133 chr18:72167187 CNDP2 -0.75 -9.12 -0.49 1.95e-17 Refractive error; CESC cis rs7267979 0.966 rs2387885 chr20:25415224 G/A cg08601574 chr20:25228251 PYGB -0.35 -5.04 -0.3 8.82e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19507727 chr1:233086292 C1orf57 -0.53 -7.1 -0.4 1.12e-11 Fibrinogen levels; CESC cis rs2404602 0.669 rs1875884 chr15:76638161 C/T cg22467129 chr15:76604101 ETFA -0.38 -5.71 -0.33 3.1e-8 Blood metabolite levels; CESC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg14393609 chr7:65229607 NA 0.47 6.26 0.36 1.51e-9 Aortic root size; CESC cis rs950776 0.518 rs12906284 chr15:78825105 C/T cg06917634 chr15:78832804 PSMA4 0.8 12.12 0.6 3.34e-27 Sudden cardiac arrest; CESC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg25811766 chr13:21894605 NA 0.76 10.27 0.53 4.91e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg02297831 chr4:17616191 MED28 0.52 5.97 0.34 7.56e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs826838 0.904 rs1554550 chr12:39208889 G/A cg26384229 chr12:38710491 ALG10B 0.78 12.94 0.62 4.96e-30 Heart rate; CESC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg20151795 chr6:28129481 ZNF389 -0.43 -5.82 -0.34 1.73e-8 Depression; CESC cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg03060546 chr3:49711283 APEH -0.47 -5.84 -0.34 1.56e-8 Parkinson's disease; CESC cis rs34779708 0.897 rs9787566 chr10:35279455 T/A cg03585969 chr10:35415529 CREM 0.77 10.16 0.53 1.05e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs1670533 1.000 rs2045068 chr4:1052212 G/A cg27284194 chr4:1044797 NA 0.45 5.68 0.33 3.56e-8 Recombination rate (females); CESC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg00166722 chr3:10149974 C3orf24 0.48 5.93 0.34 9.18e-9 Alzheimer's disease; CESC cis rs17401966 0.931 rs11584023 chr1:10302596 A/G cg15208524 chr1:10270712 KIF1B 0.41 5.34 0.31 1.95e-7 Hepatocellular carcinoma; CESC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg19163074 chr7:65112434 INTS4L2 0.43 5.37 0.31 1.71e-7 Aortic root size; CESC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg11764359 chr7:65958608 NA 0.89 13.11 0.63 1.31e-30 Aortic root size; CESC cis rs7208859 0.673 rs7211776 chr17:29120196 T/G cg13385521 chr17:29058706 SUZ12P 0.59 5.49 0.32 9.51e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7264396 0.622 rs3787165 chr20:34228946 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 3.02e-26 Total cholesterol levels; CESC cis rs7829975 0.714 rs11777085 chr8:8672429 G/C cg17143192 chr8:8559678 CLDN23 0.43 5.31 0.31 2.35e-7 Mood instability; CESC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 6.98 0.39 2.43e-11 Personality dimensions; CESC cis rs887829 0.569 rs4148326 chr2:234673462 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.54 -6.92 -0.39 3.46e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13446235 chr16:90039146 AFG3L1;CENPBD1 -0.55 -7.13 -0.4 9.32e-12 Fibrinogen levels; CESC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg12034118 chr1:209979487 IRF6 0.8 14.38 0.66 4.65e-35 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CESC cis rs734999 0.545 rs10910106 chr1:2538886 G/T cg18854424 chr1:2615690 NA 0.3 5.83 0.34 1.65e-8 Ulcerative colitis; CESC cis rs11785693 0.909 rs62489558 chr8:4968620 G/A cg26367366 chr8:4980734 NA 0.86 7.35 0.41 2.48e-12 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs1577917 0.959 rs16876540 chr6:86612519 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.29 -0.36 1.3e-9 Response to antipsychotic treatment; CESC cis rs910316 0.726 rs12882664 chr14:75446778 C/T cg11812906 chr14:75593930 NEK9 0.79 12.28 0.6 9.31e-28 Height; CESC cis rs2730245 0.527 rs2788470 chr7:158649801 G/T cg24397884 chr7:158709396 WDR60 0.78 8.03 0.44 3.25e-14 Height; CESC cis rs4727027 0.865 rs12154368 chr7:148862041 C/T cg23583168 chr7:148888333 NA -0.81 -12.68 -0.61 4.05e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs834811 0.505 rs7789711 chr7:135938979 C/T cg01726295 chr7:135938950 NA -0.36 -6.45 -0.37 5.28e-10 Post-traumatic stress disorder; CESC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg14403583 chr14:105418241 AHNAK2 -0.57 -7.86 -0.44 9.41e-14 Rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26794364 chr3:9691143 MTMR14 0.55 6.05 0.35 5e-9 Gut microbiome composition (summer); CESC cis rs6088590 0.687 rs73106933 chr20:33287425 T/C cg24642439 chr20:33292090 TP53INP2 0.67 8.95 0.48 6.36e-17 Coronary artery disease; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg06549955 chr12:110434341 GIT2 0.49 6.59 0.38 2.31e-10 Thyroid stimulating hormone; CESC cis rs2439831 0.850 rs28595038 chr15:44044859 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.68 0.38 1.43e-10 Lung cancer in ever smokers; CESC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg08470875 chr2:26401718 FAM59B -0.72 -7.98 -0.44 4.44e-14 Gut microbiome composition (summer); CESC trans rs3942852 0.568 rs10838800 chr11:48094879 C/T cg03929089 chr4:120376271 NA -0.64 -7.94 -0.44 5.67e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs4843747 0.605 rs4072779 chr16:88107290 C/T cg06374794 chr16:88002281 BANP 0.39 5.16 0.3 4.78e-7 Menopause (age at onset); CESC cis rs4568518 0.616 rs10950691 chr7:18006134 G/C cg03009463 chr7:17980271 SNX13 0.44 5.79 0.34 1.98e-8 Measles; CESC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg18876405 chr7:65276391 NA -0.55 -7.4 -0.41 1.75e-12 Aortic root size; CESC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.46 -0.54 1.15e-21 Alzheimer's disease; CESC cis rs7267979 0.932 rs6115214 chr20:25557426 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.74 -12.84 -0.62 1.1e-29 Liver enzyme levels (alkaline phosphatase); CESC cis rs1348850 0.526 rs7588049 chr2:178390778 C/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.71 -6.52 -0.37 3.49e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7818688 0.697 rs11781757 chr8:95987891 A/T cg16049864 chr8:95962084 TP53INP1 0.56 5.66 0.33 3.98e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9905704 0.918 rs304283 chr17:56785725 C/T cg12560992 chr17:57184187 TRIM37 0.59 7.06 0.4 1.45e-11 Testicular germ cell tumor; CESC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg22920501 chr2:26401640 FAM59B -0.92 -10.46 -0.54 1.19e-21 Gut microbiome composition (summer); CESC cis rs738322 0.967 rs133021 chr22:38573338 T/C cg25457927 chr22:38595422 NA -0.35 -6.43 -0.37 6.04e-10 Cutaneous nevi; CESC cis rs7824557 0.767 rs3808513 chr8:11157460 G/T cg21775007 chr8:11205619 TDH -0.52 -7.88 -0.44 8.28e-14 Retinal vascular caliber; CESC cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.4 -0.37 6.97e-10 Mood instability; CESC cis rs9527 0.590 rs10786741 chr10:104939182 G/A cg04362960 chr10:104952993 NT5C2 0.42 5.25 0.31 3.09e-7 Arsenic metabolism; CESC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg13628971 chr7:2884303 GNA12 0.39 5.03 0.3 8.97e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg03188948 chr7:1209495 NA 0.7 6.77 0.38 8.37e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7216064 0.734 rs11653507 chr17:65892064 A/T cg12091567 chr17:66097778 LOC651250 -0.62 -6.98 -0.39 2.31e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7223966 1.000 rs7223672 chr17:61720565 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.26 -0.31 2.96e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6728642 0.908 rs10203833 chr2:98017363 G/A cg26665480 chr2:98280029 ACTR1B -0.83 -8.16 -0.45 1.32e-14 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs9911578 0.839 rs7208505 chr17:57187729 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.4 5.2 0.3 3.92e-7 Intelligence (multi-trait analysis); CESC cis rs6088580 0.634 rs6088475 chr20:32964987 T/C cg08999081 chr20:33150536 PIGU -0.64 -11.19 -0.57 4.76e-24 Glomerular filtration rate (creatinine); CESC cis rs9291683 0.692 rs1558489 chr4:10325489 T/A cg11266682 chr4:10021025 SLC2A9 -0.46 -8.19 -0.45 1.12e-14 Bone mineral density; CESC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg08499158 chr17:42289980 UBTF 0.56 7.35 0.41 2.48e-12 Total body bone mineral density; CESC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg23161317 chr6:28129485 ZNF389 -0.45 -5.72 -0.33 2.89e-8 Depression; CESC cis rs9916302 0.904 rs755500 chr17:37409865 C/T cg00129232 chr17:37814104 STARD3 -0.52 -6.61 -0.38 2.06e-10 Glomerular filtration rate (creatinine); CESC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg10862848 chr6:42927986 GNMT -0.26 -6.6 -0.38 2.17e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs6723226 0.699 rs376914 chr2:32508393 G/C cg02381751 chr2:32503542 YIPF4 0.82 11.74 0.59 6.4e-26 Intelligence (multi-trait analysis); CESC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg09323728 chr8:95962352 TP53INP1 -0.41 -8.96 -0.48 5.8e-17 Type 2 diabetes; CESC cis rs3862260 0.509 rs1045827 chr1:120162442 C/T cg11530693 chr1:120165357 ZNF697 -0.69 -10.51 -0.54 7.7e-22 Systemic lupus erythematosus; CESC cis rs2228479 0.717 rs12917681 chr16:89810941 C/A cg06558623 chr16:89946397 TCF25 0.78 7.41 0.41 1.69e-12 Skin colour saturation; CESC cis rs2797160 1.000 rs6933302 chr6:126016951 T/C cg05901451 chr6:126070800 HEY2 0.46 6.63 0.38 1.86e-10 Endometrial cancer; CESC cis rs2439831 0.850 rs28476182 chr15:44139643 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.66 6.03 0.35 5.4e-9 Lung cancer in ever smokers; CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg24503407 chr1:205819492 PM20D1 0.93 17.07 0.72 1.4e-44 Menarche (age at onset); CESC cis rs9325144 0.560 rs7304568 chr12:38632408 G/A cg26384229 chr12:38710491 ALG10B -0.58 -8.9 -0.48 9.2e-17 Morning vs. evening chronotype; CESC cis rs2637266 0.627 rs2013238 chr10:78476272 A/C cg18941641 chr10:78392320 NA 0.41 7.69 0.43 2.89e-13 Pulmonary function; CESC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg18350739 chr11:68623251 NA -0.44 -6.73 -0.38 1.02e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg00684032 chr4:1343700 KIAA1530 0.4 5.46 0.32 1.1e-7 Obesity-related traits; CESC cis rs1008375 1.000 rs10939750 chr4:17692422 C/G cg16339924 chr4:17578868 LAP3 0.62 7.73 0.43 2.21e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL -0.33 -5.13 -0.3 5.64e-7 Personality dimensions; CESC cis rs7647973 0.925 rs4955439 chr3:49245645 G/T cg06212747 chr3:49208901 KLHDC8B -0.56 -7.06 -0.4 1.46e-11 Menarche (age at onset); CESC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg02772935 chr3:125709198 NA -0.45 -5.04 -0.3 8.78e-7 Blood pressure (smoking interaction); CESC trans rs7937682 0.924 rs489783 chr11:111520522 A/G cg18187862 chr3:45730750 SACM1L 0.51 6.47 0.37 4.81e-10 Primary sclerosing cholangitis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02059047 chr12:57634677 NDUFA4L2 -0.44 -6.09 -0.35 3.93e-9 Asthma; CESC cis rs3750965 0.959 rs11228490 chr11:68860872 C/G cg01403660 chr11:68851641 TPCN2 -0.4 -5.48 -0.32 9.88e-8 Hair color; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21915639 chr1:46769308 LRRC41;UQCRH 0.66 7.59 0.42 5.57e-13 Gut microbiome composition (summer); CESC cis rs7208859 0.673 rs216418 chr17:28936537 G/A cg04154034 chr17:28927549 LRRC37B2 0.67 6.03 0.35 5.4e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs1728785 1.000 rs4783657 chr16:68586322 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.29 0.41 3.49e-12 Ulcerative colitis; CESC cis rs12780046 0.536 rs10883315 chr10:101061053 C/T cg27143070 chr10:101087766 CNNM1 -0.36 -5.38 -0.31 1.61e-7 Non-glioblastoma glioma; CESC cis rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06080402 chr16:57481519 CIAPIN1;COQ9 -0.34 -5.06 -0.3 7.88e-7 Gambling; CESC cis rs2299587 0.554 rs2283106 chr8:17754330 G/A cg08627089 chr8:17753878 FGL1 -0.39 -5.5 -0.32 8.87e-8 Economic and political preferences; CESC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg27266027 chr21:40555129 PSMG1 0.44 5.2 0.3 3.91e-7 Cognitive function; CESC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg27266027 chr21:40555129 PSMG1 0.44 5.18 0.3 4.48e-7 Cognitive function; CESC cis rs7799006 0.606 rs4721527 chr7:2306655 G/A cg08027265 chr7:2291960 NA -0.58 -9.91 -0.52 6.91e-20 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21954346 chr16:68271489 ESRP2 -0.45 -6.24 -0.36 1.73e-9 Gambling; CESC cis rs3858526 0.959 rs10838901 chr11:5959128 G/A cg13902645 chr11:5959945 NA -0.67 -7.42 -0.41 1.56e-12 DNA methylation (variation); CESC trans rs7944735 0.517 rs74763661 chr11:48233772 T/C cg15704280 chr7:45808275 SEPT13 0.72 6.77 0.38 8.37e-11 Intraocular pressure; CESC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg02569458 chr12:86230093 RASSF9 0.48 7.3 0.41 3.39e-12 Major depressive disorder; CESC cis rs9303401 0.659 rs12940212 chr17:56674474 T/C cg10487724 chr17:56770010 TEX14;RAD51C 1.02 11.55 0.58 2.86e-25 Cognitive test performance; CESC cis rs10206020 0.921 rs9678719 chr2:1549628 A/G cg01028140 chr2:1542097 TPO -0.47 -5.93 -0.34 9.62e-9 IgG glycosylation; CESC cis rs9324022 0.790 rs7156824 chr14:101171480 C/A cg18089426 chr14:101175970 NA 0.57 6.08 0.35 4.18e-9 Plateletcrit; CESC cis rs9715521 0.677 rs4490528 chr4:59854572 T/G cg11281224 chr4:60001000 NA -0.51 -7.15 -0.4 8.65e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs1814175 0.817 rs10839351 chr11:49758153 C/T cg03929089 chr4:120376271 NA -0.93 -15.39 -0.69 1.28e-38 Height; CESC cis rs9815354 0.812 rs73069203 chr3:41938767 T/C cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs2294693 0.945 rs2073015 chr6:41008747 A/G cg14769373 chr6:40998127 UNC5CL -0.45 -5.81 -0.34 1.8e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs7084402 0.935 rs10763564 chr10:60360423 C/A cg07615347 chr10:60278583 BICC1 0.54 8.25 0.45 7.48e-15 Refractive error; CESC cis rs7640424 0.618 rs35798995 chr3:107914313 G/A cg09227934 chr3:107805635 CD47 -0.45 -5.82 -0.34 1.66e-8 Body mass index; CESC cis rs3749237 0.595 rs11130192 chr3:49467206 C/G cg02487422 chr3:49467188 NICN1 0.56 8.1 0.45 2.02e-14 Resting heart rate; CESC cis rs9611565 0.649 rs738422 chr22:42123399 C/T cg06634786 chr22:41940651 POLR3H 0.45 5.04 0.3 8.76e-7 Vitiligo; CESC cis rs3806843 1.000 rs2879089 chr5:140191893 A/T cg26395211 chr5:140044315 WDR55 -0.41 -5.13 -0.3 5.72e-7 Depressive symptoms (multi-trait analysis); CESC cis rs11577318 0.853 rs7541333 chr1:26622889 C/T cg00813993 chr1:26644493 UBXN11;CD52 -0.38 -6.1 -0.35 3.69e-9 Granulocyte percentage of myeloid white cells; CESC cis rs9300255 0.509 rs641760 chr12:123518866 T/C cg05973401 chr12:123451056 ABCB9 0.58 6.4 0.37 7.21e-10 Neutrophil percentage of white cells; CESC cis rs77106637 0.769 rs11603313 chr11:72588177 G/A cg04827223 chr11:72435913 ARAP1 -0.52 -5.53 -0.32 7.58e-8 Type 2 diabetes; CESC cis rs9611565 0.918 rs9538 chr22:41755857 G/T cg06481639 chr22:41940642 POLR3H -0.7 -7.34 -0.41 2.63e-12 Vitiligo; CESC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg17724175 chr1:150552817 MCL1 0.38 5.79 0.34 1.95e-8 Melanoma; CESC cis rs7937682 0.824 rs539524 chr11:111477325 A/G cg22437258 chr11:111473054 SIK2 0.71 9.54 0.51 9.65e-19 Primary sclerosing cholangitis; CESC cis rs11031096 0.678 rs11031219 chr11:4197578 G/A cg18678763 chr11:4115507 RRM1 -0.4 -5.18 -0.3 4.46e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg06456125 chr7:65229604 NA 0.41 5.73 0.33 2.71e-8 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00801868 chr3:155588370 GMPS 0.57 6.25 0.36 1.64e-9 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg07701084 chr6:150067640 NUP43 -0.41 -5.51 -0.32 8.39e-8 Lung cancer; CESC trans rs2727020 0.533 rs10839195 chr11:48973460 C/T cg00717180 chr2:96193071 NA -0.46 -6.17 -0.35 2.49e-9 Coronary artery disease; CESC cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6687430 0.532 rs67488812 chr1:10614804 A/G cg20482658 chr1:10539492 PEX14 0.39 8.02 0.44 3.37e-14 Hand grip strength; CESC trans rs931812 0.895 rs7831714 chr8:101913987 C/T cg20993868 chr7:22813445 NA 0.5 6.99 0.39 2.23e-11 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs75477785 0.590 rs1109430 chr1:209992501 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.93 6.05 0.35 4.8e-9 Cleft lip with or without cleft palate; CESC cis rs72717009 0.825 rs867624 chr1:161467837 A/T cg15358701 chr1:161410459 NA -0.7 -5.65 -0.33 4.15e-8 Rheumatoid arthritis; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg12843872 chr7:90894352 FZD1 -0.58 -6.75 -0.38 9.28e-11 Subjective well-being; CESC cis rs11190604 1.000 rs12219789 chr10:102213778 A/G cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.84 8.78 0.47 2.01e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs561341 1.000 rs8064843 chr17:30245744 A/G cg13647721 chr17:30228624 UTP6 0.6 6.06 0.35 4.66e-9 Hip circumference adjusted for BMI; CESC cis rs7103648 0.669 rs7927445 chr11:47780754 G/T cg10504702 chr11:47789108 FNBP4 0.43 5.47 0.32 1.03e-7 Diastolic blood pressure;Systolic blood pressure; CESC cis rs2732480 0.577 rs2732479 chr12:48736260 A/C cg24011408 chr12:48396354 COL2A1 0.44 5.95 0.34 8.54e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs362272 0.524 rs13150241 chr4:3367281 A/G cg08886695 chr4:3369023 RGS12 -0.43 -5.86 -0.34 1.35e-8 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22498987 chr12:120427182 CCDC64 0.55 6.91 0.39 3.58e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs13146909 chr4:98934198 C/T cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs8062405 0.573 rs8045689 chr16:28988269 C/T cg08761264 chr16:28874980 SH2B1 0.47 5.47 0.32 1.03e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13344237 chr2:25565575 DNMT3A 0.58 6.41 0.37 6.54e-10 Gut microbiome composition (summer); CESC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg23161317 chr6:28129485 ZNF389 0.46 6.04 0.35 5.25e-9 Parkinson's disease; CESC cis rs2228479 0.764 rs11641201 chr16:89983276 T/C cg06558623 chr16:89946397 TCF25 0.75 7.06 0.4 1.46e-11 Skin colour saturation; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14475554 chr1:209799191 LAMB3 0.54 7.81 0.43 1.31e-13 Fibrinogen levels; CESC cis rs6582630 0.555 rs11182422 chr12:38522833 A/G cg26384229 chr12:38710491 ALG10B 0.66 10.32 0.54 3.36e-21 Drug-induced liver injury (flucloxacillin); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20935025 chr14:35874013 NFKBIA -0.61 -6.74 -0.38 9.63e-11 Gut microbiome composition (summer); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg22783598 chr5:133747613 CDKN2AIPNL 0.47 6.11 0.35 3.55e-9 Thyroid stimulating hormone; CESC cis rs6460942 0.915 rs62448619 chr7:12457743 C/T cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg11494091 chr17:61959527 GH2 0.41 5.66 0.33 4e-8 Height; CESC cis rs7824557 0.510 rs4841524 chr8:11243126 C/G cg21775007 chr8:11205619 TDH -0.51 -7.53 -0.42 7.87e-13 Retinal vascular caliber; CESC cis rs7072216 0.763 rs4475861 chr10:100164989 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -5.07 -0.3 7.59e-7 Metabolite levels; CESC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs4844614 0.904 rs4844388 chr1:207842900 G/A cg21110645 chr1:207815933 NA 0.36 5.31 0.31 2.37e-7 LDL cholesterol; CESC cis rs9300255 0.539 rs1969355 chr12:123742061 G/A cg19016782 chr12:123741754 C12orf65 -0.36 -5.46 -0.32 1.12e-7 Neutrophil percentage of white cells; CESC cis rs2777491 0.540 rs7164684 chr15:41705008 G/T cg18705301 chr15:41695430 NDUFAF1 -1.07 -17.07 -0.72 1.45e-44 Ulcerative colitis; CESC cis rs57506017 0.585 rs5011437 chr7:12268792 A/T cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.62e-7 Neuroticism; CESC cis rs6752107 0.967 rs56049444 chr2:234157688 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.38 5.78 0.33 2.07e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg02187348 chr16:89574699 SPG7 0.54 7.14 0.4 8.81e-12 Multiple myeloma (IgH translocation); CESC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Depression; CESC cis rs2777491 1.000 rs316609 chr15:41743828 T/A cg20272979 chr15:41787780 ITPKA 0.44 6.52 0.37 3.5e-10 Ulcerative colitis; CESC cis rs11696501 0.789 rs1487319 chr20:44295943 A/G cg11783356 chr20:44313418 WFDC10B -0.32 -5.05 -0.3 8.26e-7 Brain structure; CESC cis rs9527 0.590 rs1807298 chr10:104870218 G/A cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs2717559 0.542 rs2717560 chr8:143881670 G/A cg17252645 chr8:143867129 LY6D -0.32 -5.56 -0.32 6.67e-8 Urinary tract infection frequency; CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg09177884 chr7:1199841 ZFAND2A -0.69 -9.54 -0.51 1.01e-18 Longevity;Endometriosis; CESC cis rs1728785 0.818 rs11075684 chr16:68582365 C/T cg02972257 chr16:68554789 NA -0.55 -6.21 -0.36 2.01e-9 Ulcerative colitis; CESC cis rs34734847 1.000 rs56273049 chr12:121156041 A/T cg21892295 chr12:121157589 UNC119B -0.42 -6.65 -0.38 1.66e-10 Mean corpuscular volume; CESC cis rs12220238 0.908 rs11000893 chr10:75905996 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.65 6.16 0.35 2.63e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2455799 0.613 rs12485852 chr3:15914511 G/C cg16303742 chr3:15540471 COLQ -0.37 -5.67 -0.33 3.7e-8 Mean platelet volume; CESC cis rs9549367 0.789 rs7317558 chr13:113893625 G/A cg18105134 chr13:113819100 PROZ -0.69 -8.64 -0.47 5.29e-16 Platelet distribution width; CESC trans rs1493916 1.000 rs1493916 chr18:31392577 T/G cg27147174 chr7:100797783 AP1S1 -0.52 -7.04 -0.4 1.62e-11 Life satisfaction; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09825030 chr2:85568866 NA -0.49 -6.11 -0.35 3.59e-9 Gut microbiota (bacterial taxa); CESC cis rs4971059 0.629 rs9297 chr1:155106550 A/G cg22049894 chr1:155113146 DPM3 0.46 5.89 0.34 1.18e-8 Breast cancer; CESC cis rs4604732 0.631 rs12039642 chr1:247624898 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1008375 0.932 rs11935124 chr4:17668200 G/A cg16339924 chr4:17578868 LAP3 -0.61 -7.19 -0.4 6.68e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs698833 0.852 rs698761 chr2:44547574 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.47 -5.82 -0.34 1.66e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs250677 0.522 rs11954893 chr5:148392362 A/G cg18129178 chr5:148520854 ABLIM3 -0.47 -5.22 -0.31 3.63e-7 Breast cancer; CESC cis rs4604732 0.578 rs12036417 chr1:247624805 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7772486 0.624 rs9485018 chr6:146025731 T/C cg05347473 chr6:146136440 FBXO30 -0.52 -6.85 -0.39 5e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7103648 1.000 rs10838709 chr11:47447346 C/T cg20307385 chr11:47447363 PSMC3 0.96 15.96 0.7 1.23e-40 Diastolic blood pressure;Systolic blood pressure; CESC cis rs7089973 0.584 rs4752322 chr10:116613258 A/C cg23260525 chr10:116636907 FAM160B1 0.41 7.83 0.43 1.17e-13 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6570726 0.935 rs388394 chr6:145852689 C/T cg05347473 chr6:146136440 FBXO30 0.46 6.12 0.35 3.29e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs672059 0.513 rs627064 chr1:183165716 C/T cg06211724 chr1:183155437 LAMC2 -0.35 -5.64 -0.33 4.27e-8 Hypertriglyceridemia; CESC cis rs6121246 0.529 rs6060296 chr20:30198480 T/C cg13852791 chr20:30311386 BCL2L1 0.66 6.54 0.37 3.19e-10 Mean corpuscular hemoglobin; CESC cis rs9916302 0.706 rs9891892 chr17:37479856 A/C cg07936489 chr17:37558343 FBXL20 0.89 9.66 0.51 4.24e-19 Glomerular filtration rate (creatinine); CESC cis rs2180341 0.960 rs3756996 chr6:127664258 G/C cg27446573 chr6:127587934 RNF146 1.08 15.59 0.69 2.58e-39 Breast cancer; CESC cis rs17756712 0.527 rs1747586 chr6:614375 A/C cg14374089 chr6:596013 EXOC2 0.48 5.12 0.3 5.83e-7 Vertical cup-disc ratio; CESC cis rs873946 0.557 rs4880427 chr10:134591389 T/C cg27297192 chr10:134578999 INPP5A 0.42 5.44 0.32 1.23e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs796364 1.000 rs281783 chr2:200751582 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.86 8.21 0.45 9.89e-15 Schizophrenia; CESC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg23281280 chr6:28129359 ZNF389 0.43 6.57 0.37 2.61e-10 Cardiac Troponin-T levels; CESC cis rs2549003 0.966 rs839 chr5:131819126 C/T cg21138405 chr5:131827807 IRF1 0.54 9.24 0.49 8.12e-18 Asthma (sex interaction); CESC trans rs78579285 0.545 rs113385327 chr16:88785242 A/C cg15076811 chr1:11001038 NA 0.72 6.2 0.36 2.13e-9 Joint mobility (Beighton score); CESC cis rs7635838 0.684 rs2594966 chr3:11325276 A/G cg00170343 chr3:11313890 ATG7 -0.54 -7.92 -0.44 6.42e-14 HDL cholesterol; CESC cis rs763014 0.898 rs8050792 chr16:656033 T/C cg00802000 chr16:706648 WDR90 -0.39 -6.0 -0.35 6.61e-9 Height; CESC cis rs11785400 0.793 rs4336593 chr8:143739647 A/C cg24634471 chr8:143751801 JRK -0.47 -5.93 -0.34 9.18e-9 Schizophrenia; CESC cis rs2952156 0.883 rs2941505 chr17:37832704 A/G cg20243544 chr17:37824526 PNMT 0.63 8.01 0.44 3.74e-14 Asthma; CESC cis rs7633857 0.512 rs1868109 chr3:160682500 G/A cg03342759 chr3:160939853 NMD3 -0.39 -5.03 -0.3 9.17e-7 Educational attainment (years of education); CESC cis rs1801251 1.000 rs2044449 chr2:233718808 G/A cg25237894 chr2:233734115 C2orf82 -0.48 -8.37 -0.46 3.46e-15 Coronary artery disease; CESC cis rs3105593 1.000 rs3109879 chr15:50837618 A/G cg08437265 chr15:50716283 USP8 0.43 5.62 0.33 4.77e-8 QT interval; CESC cis rs11235843 0.853 rs55910552 chr11:73525917 A/T cg03538470 chr11:73498718 MRPL48 -0.53 -5.03 -0.3 8.92e-7 Hand grip strength; CESC trans rs10934447 0.512 rs1696528 chr3:118043411 T/C cg24652809 chr6:168813688 NA -0.49 -6.05 -0.35 4.91e-9 Neuroticism; CESC cis rs35146811 0.586 rs10267231 chr7:99595480 T/C cg22906224 chr7:99728672 NA 0.45 5.36 0.31 1.79e-7 Coronary artery disease; CESC trans rs10242455 0.571 rs11972210 chr7:99206943 A/C cg09045935 chr12:6379348 NA 0.73 6.03 0.35 5.47e-9 Blood metabolite levels; CESC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg14393609 chr7:65229607 NA 0.46 6.04 0.35 5.09e-9 Aortic root size; CESC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs2342371 0.545 rs7646174 chr3:196210808 T/C cg15048948 chr3:196158458 UBXN7 -0.39 -5.5 -0.32 9.12e-8 Fat distribution (HIV); CESC cis rs9831754 0.756 rs13084140 chr3:78426004 G/A cg06138941 chr3:78371609 NA -0.49 -6.27 -0.36 1.5e-9 Calcium levels; CESC cis rs1371867 0.846 rs1788194 chr8:101277916 T/C cg11906718 chr8:101322791 RNF19A 0.5 6.39 0.37 7.26e-10 Atrioventricular conduction; CESC cis rs7680126 0.596 rs17418533 chr4:10316941 T/C cg00071950 chr4:10020882 SLC2A9 -0.48 -5.34 -0.31 2.03e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg02737830 chr12:64616354 C12orf66 0.49 6.47 0.37 4.81e-10 Tetralogy of Fallot; CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.19 -0.36 2.27e-9 Depression; CESC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.75 -10.0 -0.52 3.38e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg03433033 chr1:76189801 ACADM -0.61 -7.34 -0.41 2.67e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6788895 0.661 rs16862837 chr3:150469858 A/C cg09723797 chr3:150481914 SIAH2 -0.65 -5.75 -0.33 2.42e-8 Breast cancer; CESC cis rs7714584 1.000 rs13361189 chr5:150223387 A/G cg22134413 chr5:150180641 NA 0.52 5.5 0.32 8.85e-8 Crohn's disease; CESC trans rs4942242 0.663 rs1472330 chr13:44209628 A/G cg19169023 chr15:41853346 TYRO3 0.56 7.12 0.4 1.03e-11 Response to tocilizumab in rheumatoid arthritis; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13486387 chr9:94124044 AUH -0.51 -6.36 -0.36 8.9e-10 Ulcerative colitis; CESC cis rs4835473 0.897 rs13135627 chr4:144612252 G/A cg25736465 chr4:144833511 NA -0.41 -5.97 -0.34 7.63e-9 Immature fraction of reticulocytes; CESC cis rs8114671 0.562 rs4911163 chr20:33470694 C/T cg06115741 chr20:33292138 TP53INP2 0.48 5.8 0.34 1.91e-8 Height; CESC cis rs929354 0.685 rs7807856 chr7:156934498 T/C cg05182265 chr7:156933206 UBE3C -0.49 -7.04 -0.4 1.69e-11 Body mass index; CESC cis rs1847202 0.762 rs13093504 chr3:72949855 T/C cg10804678 chr3:72788309 NA -0.4 -5.32 -0.31 2.26e-7 Motion sickness; CESC cis rs714031 1.000 rs5750869 chr22:40065332 T/C cg21377881 chr22:40064566 CACNA1I -0.37 -6.04 -0.35 5.21e-9 Schizophrenia; CESC cis rs6032067 0.777 rs13038275 chr20:43780988 A/T cg11264863 chr20:43835661 SEMG1 0.5 5.39 0.31 1.54e-7 Blood protein levels; CESC cis rs3791556 1.000 rs3791558 chr2:240113255 G/A cg03281426 chr2:240109471 HDAC4 0.49 5.64 0.33 4.44e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7424096 0.613 rs17332671 chr2:37244124 C/G cg14987922 chr2:37194071 STRN 0.49 5.4 0.32 1.45e-7 High light scatter reticulocyte percentage of red cells; CESC cis rs9308731 0.644 rs1837369 chr2:111874276 C/T cg04202892 chr2:111875749 ACOXL 0.51 7.66 0.43 3.41e-13 Chronic lymphocytic leukemia; CESC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg05373962 chr22:49881684 NA -0.38 -6.75 -0.38 9.34e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs6088590 1.000 rs6058111 chr20:33310999 T/C cg06115741 chr20:33292138 TP53INP2 0.57 7.05 0.4 1.59e-11 Coronary artery disease; CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg18337363 chr3:52569053 NT5DC2 0.36 7.11 0.4 1.07e-11 Electroencephalogram traits; CESC cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg03467027 chr4:99064603 C4orf37 0.51 6.37 0.36 8.37e-10 Colonoscopy-negative controls vs population controls; CESC cis rs56235845 0.964 rs11741640 chr5:176792743 G/A cg17509989 chr5:176798049 RGS14 0.72 8.01 0.44 3.6e-14 Hemoglobin concentration;Hematocrit; CESC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg13770153 chr20:60521292 NA -0.44 -5.88 -0.34 1.21e-8 Body mass index; CESC cis rs6662572 0.950 rs11579176 chr1:46050561 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 5.69 0.33 3.39e-8 Blood protein levels; CESC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg05132306 chr1:1846340 CALML6 -0.31 -6.45 -0.37 5.43e-10 Body mass index; CESC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg13798912 chr7:905769 UNC84A -0.57 -5.67 -0.33 3.76e-8 Cerebrospinal P-tau181p levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05785653 chr15:45695817 SPATA5L1 -0.49 -6.1 -0.35 3.75e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16625000 chr3:184081092 POLR2H 0.63 7.3 0.41 3.28e-12 Gut microbiome composition (summer); CESC cis rs910316 0.737 rs175049 chr14:75481368 C/T cg11812906 chr14:75593930 NEK9 -0.8 -12.88 -0.62 8.29e-30 Height; CESC cis rs7020830 0.931 rs7034554 chr9:37081301 A/G cg14294708 chr9:37120828 ZCCHC7 1.28 25.5 0.84 2.85e-73 Schizophrenia; CESC cis rs72945132 0.882 rs12294540 chr11:70118973 A/T cg00319359 chr11:70116639 PPFIA1 0.79 7.83 0.43 1.15e-13 Coronary artery disease; CESC cis rs9811920 0.609 rs17174947 chr3:99598884 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs3947 0.687 rs1736065 chr8:11685453 A/G cg00262122 chr8:11665843 FDFT1 -0.5 -5.14 -0.3 5.23e-7 Blood protein levels; CESC cis rs11030122 0.673 rs11030660 chr11:4043268 T/C cg18678763 chr11:4115507 RRM1 -0.49 -6.63 -0.38 1.91e-10 Mean platelet volume;Platelet distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09573809 chr19:58874563 ZNF497 0.53 6.16 0.35 2.69e-9 Gut microbiome composition (summer); CESC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg22638593 chr5:131593259 PDLIM4 0.4 5.24 0.31 3.26e-7 Breast cancer; CESC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.88e-10 Life satisfaction; CESC trans rs7690543 0.579 rs12498828 chr4:67996799 C/T cg05505961 chr17:66375071 ARSG -0.53 -6.17 -0.35 2.6e-9 Glucose homeostasis traits; CESC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg26939375 chr7:64535504 NA 0.75 10.67 0.55 2.37e-22 Aortic root size; CESC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg04518342 chr5:131593106 PDLIM4 -0.42 -6.39 -0.37 7.57e-10 Acylcarnitine levels; CESC cis rs763121 0.853 rs5750633 chr22:38993467 A/G cg06544989 chr22:39130855 UNC84B 0.5 9.21 0.49 1e-17 Menopause (age at onset); CESC trans rs7937682 0.961 rs4935790 chr11:111633014 T/C cg18187862 chr3:45730750 SACM1L -0.56 -6.16 -0.35 2.67e-9 Primary sclerosing cholangitis; CESC trans rs9929218 0.871 rs1862748 chr16:68832943 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.64 -8.32 -0.46 4.57e-15 Colorectal cancer; CESC cis rs6866344 0.570 rs1071881 chr5:178135917 C/T cg03877680 chr5:178157825 ZNF354A 0.83 10.2 0.53 8.29e-21 Neutrophil percentage of white cells; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19512021 chr11:95524497 CEP57 0.46 6.58 0.37 2.51e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs412050 0.696 rs76843711 chr22:22262093 C/A cg17089214 chr22:22089827 YPEL1 0.74 6.09 0.35 3.88e-9 Attention deficit hyperactivity disorder; CESC cis rs7100689 0.556 rs946893 chr10:82023524 A/G cg00277334 chr10:82204260 NA -0.51 -6.49 -0.37 4.22e-10 Post bronchodilator FEV1; CESC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg22968622 chr17:43663579 NA 0.79 10.7 0.55 1.92e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1514687 0.534 rs11694726 chr2:1460220 C/T cg13703866 chr2:1479523 TPO -0.76 -5.15 -0.3 5.08e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs2380220 0.606 rs4559095 chr6:95994154 A/C cg15832292 chr6:96025679 MANEA 0.63 7.09 0.4 1.22e-11 Behavioural disinhibition (generation interaction); CESC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg14159672 chr1:205819179 PM20D1 -0.46 -6.24 -0.36 1.76e-9 Menarche (age at onset); CESC cis rs116095464 0.510 rs7714944 chr5:231765 C/T cg22857025 chr5:266934 NA -1.27 -18.09 -0.74 3.37e-48 Breast cancer; CESC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg06873352 chr17:61820015 STRADA 0.49 7.1 0.4 1.12e-11 Height; CESC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg24250549 chr1:154909240 PMVK 0.73 10.85 0.55 6.18e-23 Prostate cancer; CESC cis rs4889855 0.556 rs61096326 chr17:78543796 G/C cg16591659 chr17:78472290 NA 0.38 6.32 0.36 1.08e-9 Fractional excretion of uric acid; CESC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg11766577 chr21:47581405 C21orf56 -0.45 -6.11 -0.35 3.59e-9 Testicular germ cell tumor; CESC cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg18876405 chr7:65276391 NA -0.59 -7.87 -0.44 9.13e-14 Aortic root size; CESC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg22963979 chr7:1858916 MAD1L1 0.42 5.73 0.33 2.69e-8 Bipolar disorder and schizophrenia; CESC cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg06713675 chr4:122721982 EXOSC9 -0.51 -6.96 -0.39 2.71e-11 Type 2 diabetes; CESC cis rs763121 0.853 rs2267394 chr22:39101633 T/C cg21395723 chr22:39101663 GTPBP1 0.49 6.76 0.38 8.89e-11 Menopause (age at onset); CESC cis rs10851478 0.872 rs34414487 chr15:49783775 A/G cg08060515 chr15:49448048 GALK2;COPS2 0.42 5.19 0.3 4.12e-7 Oral cavity cancer; CESC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg15664640 chr17:80829946 TBCD 0.4 5.73 0.33 2.69e-8 Breast cancer; CESC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg07701084 chr6:150067640 NUP43 0.47 6.58 0.37 2.47e-10 Lung cancer; CESC cis rs9910055 0.512 rs7209801 chr17:42323376 G/A cg19774624 chr17:42201019 HDAC5 -0.47 -5.92 -0.34 9.73e-9 Total body bone mineral density; CESC cis rs1957429 0.520 rs72625645 chr14:65343431 G/C cg23373153 chr14:65346875 NA -0.84 -6.3 -0.36 1.22e-9 Pediatric areal bone mineral density (radius); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19650814 chr6:100016539 CCNC 0.59 7.15 0.4 8.46e-12 Gut microbiome composition (summer); CESC cis rs892961 0.932 rs7208336 chr17:75412932 T/C cg05865280 chr17:75406074 SEPT9 0.62 12.67 0.61 4.57e-29 Airflow obstruction; CESC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg07308232 chr7:1071921 C7orf50 -0.56 -8.07 -0.44 2.4e-14 Longevity;Endometriosis; CESC trans rs2321882 0.881 rs7990810 chr13:59393390 T/C cg20914879 chr14:56566808 NA -0.43 -6.17 -0.35 2.51e-9 Body mass index; CESC cis rs7116495 0.609 rs7121080 chr11:71703935 G/A cg07596299 chr11:71824057 C11orf51 -0.8 -5.35 -0.31 1.92e-7 Severe influenza A (H1N1) infection; CESC cis rs10992471 1.000 rs10992471 chr9:95559505 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.4 5.18 0.3 4.42e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs1003719 0.715 rs2835640 chr21:38537380 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.06 -0.44 2.72e-14 Eye color traits; CESC cis rs6546550 0.901 rs10167142 chr2:70062360 T/C cg02498382 chr2:70120550 SNRNP27 -0.39 -6.78 -0.38 7.75e-11 Prevalent atrial fibrillation; CESC cis rs9522267 0.535 rs2039915 chr13:112238794 C/T cg10483660 chr13:112241077 NA -0.32 -5.63 -0.33 4.64e-8 Hepatitis; CESC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg19717773 chr7:2847554 GNA12 -0.56 -7.87 -0.44 9.12e-14 Height; CESC cis rs473651 0.935 rs472357 chr2:239355454 A/G cg18131467 chr2:239335373 ASB1 -0.97 -20.36 -0.78 3.98e-56 Multiple system atrophy; CESC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg04369109 chr6:150039330 LATS1 -0.48 -6.59 -0.38 2.33e-10 Lung cancer; CESC cis rs3105593 0.555 rs3131560 chr15:50775562 T/C cg05456662 chr15:50716270 USP8 0.38 5.12 0.3 5.74e-7 QT interval; CESC cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg00750074 chr16:89608354 SPG7 -0.37 -5.31 -0.31 2.33e-7 Multiple myeloma (IgH translocation); CESC cis rs12477438 0.798 rs13393860 chr2:99590397 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -10.22 -0.53 6.79e-21 Chronic sinus infection; CESC cis rs8014204 0.804 rs7154845 chr14:75247746 A/G cg08847533 chr14:75593920 NEK9 0.46 5.88 0.34 1.2e-8 Caffeine consumption; CESC trans rs35110281 0.782 rs9981291 chr21:45031458 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 6.99 0.39 2.2e-11 Mean corpuscular volume; CESC cis rs2635047 0.967 rs9960264 chr18:44606996 T/C cg19077165 chr18:44547161 KATNAL2 -0.53 -7.12 -0.4 9.94e-12 Educational attainment; CESC cis rs36051895 0.623 rs7870536 chr9:5245493 C/T cg02405213 chr9:5042618 JAK2 -0.53 -6.61 -0.38 2.09e-10 Pediatric autoimmune diseases; CESC cis rs5753618 0.504 rs5753661 chr22:31899797 C/A cg02404636 chr22:31891804 SFI1 0.42 5.85 0.34 1.47e-8 Colorectal cancer; CESC trans rs61931739 0.534 rs1387789 chr12:34056304 C/A cg26384229 chr12:38710491 ALG10B 0.53 7.12 0.4 9.92e-12 Morning vs. evening chronotype; CESC cis rs10876993 0.890 rs1092472 chr12:58036688 G/T cg18357645 chr12:58087776 OS9 0.59 9.02 0.48 3.89e-17 Celiac disease or Rheumatoid arthritis; CESC trans rs2121875 0.667 rs12518129 chr5:44171952 A/G cg07292773 chr6:156718177 NA -0.48 -6.12 -0.35 3.38e-9 Prostate cancer; CESC cis rs752010 0.806 rs10890148 chr1:42091517 T/C cg06885757 chr1:42089581 HIVEP3 0.49 8.24 0.45 8.1e-15 Lupus nephritis in systemic lupus erythematosus; CESC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg06873352 chr17:61820015 STRADA 0.72 12.88 0.62 8.42e-30 Prudent dietary pattern; CESC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg08736216 chr1:53307985 ZYG11A -0.41 -7.3 -0.41 3.45e-12 Monocyte count; CESC cis rs7264396 0.635 rs6060675 chr20:34493614 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.08 -0.56 1.08e-23 Total cholesterol levels; CESC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg10351095 chr21:47802916 PCNT 0.43 5.55 0.32 7.02e-8 Testicular germ cell tumor; CESC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4481887 0.927 rs12744455 chr1:248479960 A/G cg00666640 chr1:248458726 OR2T12 0.35 5.79 0.34 1.95e-8 Common traits (Other); CESC cis rs4737010 0.570 rs2111804 chr8:41644266 A/T cg08923054 chr8:41654455 ANK1 0.55 6.87 0.39 4.58e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC cis rs477692 0.583 rs2008387 chr10:131448764 C/T cg05714579 chr10:131428358 MGMT -0.75 -11.37 -0.57 1.15e-24 Response to temozolomide; CESC cis rs7828089 0.934 rs12544427 chr8:22263115 C/T cg12081754 chr8:22256438 SLC39A14 -0.42 -5.53 -0.32 7.82e-8 Verbal declarative memory; CESC cis rs7259376 0.902 rs10409947 chr19:22512518 G/A cg02657401 chr19:22469223 NA -0.26 -5.24 -0.31 3.22e-7 Menopause (age at onset); CESC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg04369109 chr6:150039330 LATS1 -0.38 -5.14 -0.3 5.4e-7 Lung cancer; CESC cis rs4595586 0.525 rs6580891 chr12:39370127 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs2034088 0.833 rs4968120 chr17:431364 T/G cg06217071 chr17:408420 NA 0.48 9.14 0.49 1.7e-17 Hip circumference adjusted for BMI; CESC cis rs2635047 0.615 rs2576052 chr18:44690107 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.4 5.04 0.3 8.84e-7 Educational attainment; CESC cis rs4654899 1.000 rs4654896 chr1:21356930 T/C cg05370193 chr1:21551575 ECE1 0.41 6.26 0.36 1.55e-9 Superior frontal gyrus grey matter volume; CESC cis rs2243480 1.000 rs56291018 chr7:65390339 G/A cg12463550 chr7:65579703 CRCP 0.71 5.5 0.32 8.79e-8 Diabetic kidney disease; CESC cis rs16854884 0.582 rs35211123 chr3:143640171 A/T cg06585982 chr3:143692056 C3orf58 0.54 7.06 0.4 1.47e-11 Economic and political preferences (feminism/equality); CESC cis rs7267979 0.816 rs8115257 chr20:25207931 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.67 11.49 0.58 4.6e-25 Liver enzyme levels (alkaline phosphatase); CESC cis rs11608355 0.515 rs34038572 chr12:109901657 A/G cg05360138 chr12:110035743 NA 0.81 8.84 0.48 1.41e-16 Neuroticism; CESC cis rs763121 0.853 rs5750622 chr22:38956464 C/G cg14440974 chr22:39074834 NA -0.4 -5.31 -0.31 2.32e-7 Menopause (age at onset); CESC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.57 7.04 0.4 1.63e-11 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23959119 chr19:42806179 PRR19;PAFAH1B3 0.57 6.06 0.35 4.54e-9 Gut microbiome composition (summer); CESC cis rs4595586 0.545 rs6580888 chr12:39369704 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs921968 0.509 rs3856548 chr2:219398164 C/T cg02176678 chr2:219576539 TTLL4 -0.54 -9.78 -0.51 1.78e-19 Mean corpuscular hemoglobin concentration; CESC cis rs734999 0.588 rs3748817 chr1:2525665 T/C cg18854424 chr1:2615690 NA 0.27 5.46 0.32 1.12e-7 Ulcerative colitis; CESC cis rs483180 0.859 rs478093 chr1:120255126 C/T cg19096424 chr1:120255104 PHGDH -0.77 -9.17 -0.49 1.33e-17 Macular telangiectasia type 2; CESC cis rs7666738 0.830 rs28878289 chr4:98855181 C/T cg05340658 chr4:99064831 C4orf37 0.75 11.16 0.57 5.89e-24 Colonoscopy-negative controls vs population controls; CESC cis rs6963495 0.818 rs1355614 chr7:105179176 A/G cg13798780 chr7:105162888 PUS7 0.6 6.99 0.39 2.2e-11 Bipolar disorder (body mass index interaction); CESC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.46 6.4 0.37 6.98e-10 Menopause (age at onset); CESC trans rs2727020 0.729 rs588458 chr11:49214048 C/A cg03929089 chr4:120376271 NA 0.78 11.9 0.59 1.91e-26 Coronary artery disease; CESC cis rs10479542 0.503 rs12719865 chr5:178993566 C/T cg26516362 chr5:178986906 RUFY1 0.47 7.31 0.41 3.11e-12 Lung cancer; CESC cis rs1008375 0.966 rs10006317 chr4:17702525 A/G cg16339924 chr4:17578868 LAP3 0.62 7.64 0.42 4.03e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20586607 chr14:50235780 KLHDC2 -0.45 -6.02 -0.35 5.72e-9 Height; CESC cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.61 -8.67 -0.47 4.54e-16 Personality dimensions; CESC cis rs1355223 0.833 rs286885 chr11:34687346 G/T cg11058730 chr11:34937778 PDHX;APIP 0.44 5.78 0.33 2.11e-8 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs4253772 0.575 rs74879643 chr22:46660014 T/C cg24881330 chr22:46731750 TRMU 0.74 5.63 0.33 4.6e-8 LDL cholesterol;Cholesterol, total; CESC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg19077165 chr18:44547161 KATNAL2 -0.53 -7.83 -0.43 1.17e-13 Personality dimensions; CESC cis rs910316 1.000 rs12590452 chr14:75548756 T/C cg11812906 chr14:75593930 NEK9 0.91 16.04 0.7 6.55e-41 Height; CESC cis rs2415984 0.622 rs11846013 chr14:46932291 A/C cg14871534 chr14:47121158 RPL10L 0.35 5.26 0.31 3.02e-7 Number of children ever born; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg09133386 chr6:20404188 E2F3 -0.45 -6.02 -0.35 5.94e-9 Height; CESC cis rs1707322 0.721 rs10789470 chr1:46158331 T/G cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs698833 0.886 rs2927433 chr2:44580737 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.87 0.34 1.33e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs13082711 0.911 rs3755652 chr3:27472936 A/G cg02860705 chr3:27208620 NA -0.56 -5.91 -0.34 1.02e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs9303401 0.614 rs12947982 chr17:57140301 A/G cg12560992 chr17:57184187 TRIM37 0.5 5.22 0.31 3.67e-7 Cognitive test performance; CESC cis rs2276314 0.802 rs9963714 chr18:33592056 T/C cg19628046 chr18:33552617 C18orf21 0.51 5.58 0.32 5.92e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs3791406 0.654 rs3791409 chr2:240030606 C/G cg13090969 chr2:240043331 HDAC4 -0.48 -5.75 -0.33 2.42e-8 Skin aging (microtopography measurement); CESC cis rs909674 0.775 rs8138462 chr22:39839670 G/C cg05872129 chr22:39784769 NA -0.77 -10.35 -0.54 2.59e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs854765 0.647 rs712267 chr17:18021607 G/A cg16928487 chr17:17741425 SREBF1 -0.46 -7.14 -0.4 9.06e-12 Total body bone mineral density; CESC trans rs6964833 1.000 rs4717906 chr7:74086247 G/A cg07504079 chr7:72649617 NCF1B -0.55 -6.23 -0.36 1.79e-9 Menarche (age at onset); CESC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg24846343 chr22:24311635 DDTL 0.61 10.31 0.54 3.42e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6963495 0.818 rs73192107 chr7:105168095 G/A cg02135003 chr7:105160482 PUS7 -0.46 -5.5 -0.32 9.1e-8 Bipolar disorder (body mass index interaction); CESC cis rs2295499 0.674 rs34626871 chr4:2637560 C/T cg08330972 chr4:2403930 ZFYVE28 -0.34 -5.4 -0.32 1.46e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs6088580 0.634 rs6087579 chr20:32985155 A/G cg24642439 chr20:33292090 TP53INP2 -0.54 -7.09 -0.4 1.21e-11 Glomerular filtration rate (creatinine); CESC trans rs13098911 0.540 rs13079869 chr3:46008087 G/A cg10236987 chr1:228114221 WNT9A 0.57 6.14 0.35 2.95e-9 Celiac disease; CESC cis rs950169 0.922 rs12906983 chr15:84931022 G/A cg17507749 chr15:85114479 UBE2QP1 0.59 6.46 0.37 5e-10 Schizophrenia; CESC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.92 0.62 6.2e-30 Alzheimer's disease; CESC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg11764359 chr7:65958608 NA -0.78 -11.32 -0.57 1.76e-24 Aortic root size; CESC cis rs7191439 0.657 rs3826076 chr16:88780518 C/T cg27087555 chr16:88793112 FAM38A 1.05 9.3 0.5 5.62e-18 Plateletcrit; CESC cis rs2404602 0.692 rs67570291 chr15:77020502 T/C cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC cis rs7089973 0.624 rs1359080 chr10:116582419 C/A cg25233709 chr10:116636983 FAM160B1 0.35 5.42 0.32 1.35e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11522767 chr6:157342961 ARID1B -0.42 -6.03 -0.35 5.46e-9 Gambling; CESC cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg08847533 chr14:75593920 NEK9 1.02 19.36 0.77 1.26e-52 Height; CESC cis rs2180341 0.961 rs3798857 chr6:127659473 A/T cg27446573 chr6:127587934 RNF146 1.09 16.35 0.71 5.12e-42 Breast cancer; CESC cis rs9549367 0.789 rs2287247 chr13:113889212 A/G cg18105134 chr13:113819100 PROZ -0.68 -8.29 -0.45 5.77e-15 Platelet distribution width; CESC trans rs7615952 0.551 rs6438945 chr3:125634473 G/A cg07211511 chr3:129823064 LOC729375 -1.1 -13.63 -0.64 2.03e-32 Blood pressure (smoking interaction); CESC trans rs12599106 0.715 rs34006830 chr16:34878550 C/A cg03395511 chr6:291903 DUSP22 -0.7 -8.58 -0.47 8.27e-16 Menopause (age at onset); CESC cis rs11098499 0.955 rs35197422 chr4:120169314 T/G cg24375607 chr4:120327624 NA 0.43 5.22 0.31 3.66e-7 Corneal astigmatism; CESC trans rs7937682 0.883 rs568038 chr11:111432161 A/C cg18187862 chr3:45730750 SACM1L -0.55 -6.75 -0.38 9.09e-11 Primary sclerosing cholangitis; CESC cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg24531977 chr5:56204891 C5orf35 -0.41 -5.11 -0.3 6.22e-7 Coronary artery disease; CESC cis rs2857078 0.627 rs1476512 chr17:42330122 C/T cg19774624 chr17:42201019 HDAC5 0.42 5.69 0.33 3.38e-8 Red cell distribution width;Reticulocyte count; CESC cis rs965469 0.947 rs6037578 chr20:3345911 T/C cg25506879 chr20:3388711 C20orf194 -0.55 -5.85 -0.34 1.43e-8 IFN-related cytopenia; CESC cis rs2070433 1.000 rs2839306 chr21:47954219 G/T cg12379764 chr21:47803548 PCNT -0.56 -6.66 -0.38 1.57e-10 Lymphocyte counts; CESC cis rs739401 0.595 rs2237903 chr11:2967901 C/T cg25174290 chr11:3078921 CARS 0.59 7.79 0.43 1.53e-13 Longevity; CESC cis rs3733585 0.699 rs1079128 chr4:9951221 T/C cg11266682 chr4:10021025 SLC2A9 -0.59 -11.3 -0.57 1.99e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs4038131 0.818 rs11096484 chr2:17985852 A/G cg12680326 chr20:2821316 VPS16;FAM113A 0.88 6.04 0.35 5.28e-9 Psychosis and Alzheimer's disease; CESC cis rs11958404 1.000 rs72816532 chr5:157413130 C/T cg05962755 chr5:157440814 NA 0.52 5.95 0.34 8.38e-9 IgG glycosylation; CESC trans rs4650994 0.525 rs2493860 chr1:178541492 A/G cg05059571 chr16:84539110 KIAA1609 -0.39 -6.01 -0.35 5.99e-9 HDL cholesterol levels;HDL cholesterol; CESC cis rs2624839 0.629 rs2526397 chr3:50187790 A/C cg08283408 chr3:49949060 MON1A 0.39 5.1 0.3 6.43e-7 Intelligence (multi-trait analysis); CESC trans rs11039798 0.512 rs28453037 chr11:49006929 C/A cg03929089 chr4:120376271 NA 0.59 6.09 0.35 3.97e-9 Axial length; CESC cis rs9467711 0.606 rs9348709 chr6:26360311 G/A cg14345882 chr6:26364793 BTN3A2 0.59 6.06 0.35 4.66e-9 Autism spectrum disorder or schizophrenia; CESC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg11494091 chr17:61959527 GH2 0.72 12.28 0.6 1e-27 Prudent dietary pattern; CESC trans rs2727020 0.595 rs10769583 chr11:49483193 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.88 -0.72 6.55e-44 Coronary artery disease; CESC cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 0.803 rs423187 chr7:65509499 G/C cg12463550 chr7:65579703 CRCP 0.7 5.41 0.32 1.41e-7 Diabetic kidney disease; CESC cis rs4237845 0.844 rs4630335 chr12:58302258 A/G cg02175503 chr12:58329896 NA 0.59 7.98 0.44 4.34e-14 Intelligence (multi-trait analysis); CESC cis rs117623576 0.618 rs211413 chr10:32396902 C/A cg03047570 chr10:32398778 NA 0.69 7.67 0.43 3.33e-13 Anti-saccade response; CESC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg04772025 chr11:68637568 NA 0.59 6.81 0.39 6.62e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11098499 0.909 rs10020034 chr4:120294331 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.23 0.49 8.9e-18 Corneal astigmatism; CESC cis rs317689 0.690 rs570256 chr12:69662929 A/T cg20891283 chr12:69753455 YEATS4 0.48 5.28 0.31 2.76e-7 Response to diuretic therapy; CESC cis rs4588572 0.774 rs4072853 chr5:77656402 G/C cg11547950 chr5:77652471 NA 0.47 6.2 0.36 2.21e-9 Triglycerides; CESC cis rs116095464 0.558 rs13354585 chr5:242263 G/C cg20965017 chr5:231967 SDHA -0.47 -5.35 -0.31 1.88e-7 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15422050 chr6:88412138 NCRNA00120;AKIRIN2 -0.52 -6.26 -0.36 1.52e-9 Ulcerative colitis; CESC trans rs2823962 0.759 rs4485640 chr21:18018262 A/T cg06419850 chr17:4688683 VMO1 -0.42 -6.11 -0.35 3.45e-9 Amyotrophic lateral sclerosis; CESC cis rs854765 0.551 rs12600546 chr17:17867614 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.22 0.45 9.43e-15 Total body bone mineral density; CESC cis rs4803468 1.000 rs284663 chr19:41932612 C/T cg08639244 chr19:41945921 ATP5SL -0.43 -5.21 -0.3 3.89e-7 Height; CESC cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4631830 0.540 rs2843562 chr10:51496796 A/G cg20129853 chr10:51489980 NA 0.29 5.28 0.31 2.64e-7 Prostate-specific antigen levels; CESC trans rs2488856 0.624 rs7151863 chr14:43614110 A/G cg14326805 chr9:71737756 TJP2 0.37 6.03 0.35 5.51e-9 Osteoprotegerin levels; CESC cis rs7937682 0.924 rs11213968 chr11:111527629 G/C cg09085632 chr11:111637200 PPP2R1B -1.0 -16.13 -0.7 3.03e-41 Primary sclerosing cholangitis; CESC cis rs2342371 0.848 rs9864836 chr3:196200737 C/T cg15048948 chr3:196158458 UBXN7 0.42 5.58 0.32 5.9e-8 Fat distribution (HIV); CESC cis rs1348850 0.668 rs13010396 chr2:178492934 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 5.4 0.31 1.48e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg23048001 chr7:2026167 MAD1L1 0.47 6.14 0.35 2.93e-9 Bipolar disorder and schizophrenia; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg21843114 chr4:26334859 RBPJ -0.45 -6.19 -0.36 2.32e-9 Breast cancer;Type 2 diabetes; CESC trans rs459571 0.959 rs465535 chr9:136910905 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.57 -7.48 -0.42 1.12e-12 Platelet distribution width; CESC cis rs72781680 0.898 rs72796152 chr2:23933626 G/A cg20701182 chr2:24300061 SF3B14 0.66 5.92 0.34 1.01e-8 Lymphocyte counts; CESC cis rs590820 0.712 rs4846913 chr1:230294715 A/C cg20703242 chr1:230279135 GALNT2 -0.31 -5.15 -0.3 5e-7 Metabolite levels (lipoprotein measures); CESC cis rs360798 0.512 rs11893131 chr2:63079528 C/A cg17519650 chr2:63277830 OTX1 0.5 6.38 0.36 7.78e-10 Coronary artery disease; CESC cis rs2108622 0.727 rs7256877 chr19:15980683 T/C cg13772218 chr19:15982569 NA 0.3 5.87 0.34 1.27e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg05025164 chr4:1340916 KIAA1530 0.89 12.06 0.6 5.43e-27 Longevity; CESC cis rs863345 0.564 rs1418844 chr1:158457569 A/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.14 -0.4 9.13e-12 Pneumococcal bacteremia; CESC cis rs654950 0.783 rs668359 chr1:42003425 A/C cg06885757 chr1:42089581 HIVEP3 -0.49 -8.13 -0.45 1.61e-14 Airway imaging phenotypes; CESC cis rs10870270 0.830 rs10781571 chr10:133774316 G/C cg17892150 chr10:133769511 PPP2R2D -0.86 -12.57 -0.61 9.6e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2070488 0.930 rs928813 chr3:38528537 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.96 18.05 0.74 4.84e-48 Electrocardiographic conduction measures; CESC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.49 -0.5 1.38e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs477692 0.673 rs579325 chr10:131363688 C/T cg24747557 chr10:131355152 MGMT -0.38 -5.17 -0.3 4.67e-7 Response to temozolomide; CESC cis rs13336428 0.730 rs3946124 chr16:1525779 A/G cg07835181 chr16:1525278 CLCN7 -0.72 -9.98 -0.52 4e-20 Bone mineral density; CESC cis rs7267979 1.000 rs1888998 chr20:25291826 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -16.08 -0.7 4.65e-41 Liver enzyme levels (alkaline phosphatase); CESC cis rs1863918 0.807 rs4701049 chr5:178545214 G/T cg21905437 chr5:178450457 ZNF879 0.36 5.04 0.3 8.55e-7 Depression in response to interferon-based therapy in chronic hepatitis C; CESC cis rs4835473 0.868 rs1828503 chr4:144914507 A/G cg25736465 chr4:144833511 NA -0.46 -7.04 -0.4 1.69e-11 Immature fraction of reticulocytes; CESC cis rs3096299 0.967 rs16965692 chr16:89471482 C/T cg02187348 chr16:89574699 SPG7 0.52 7.04 0.4 1.68e-11 Multiple myeloma (IgH translocation); CESC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg22105103 chr4:187893119 NA 0.51 7.69 0.43 2.88e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs6938 0.618 rs11072514 chr15:75221865 T/A cg14664628 chr15:75095509 CSK -0.53 -6.91 -0.39 3.64e-11 Breast cancer; CESC cis rs4566357 0.615 rs10178098 chr2:227914425 C/T cg05526886 chr2:227700861 RHBDD1 -0.45 -5.93 -0.34 9.37e-9 Coronary artery disease; CESC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg18758796 chr5:131593413 PDLIM4 -0.5 -7.22 -0.41 5.5e-12 Acylcarnitine levels; CESC cis rs11958404 0.932 rs72816540 chr5:157414500 T/C cg05962755 chr5:157440814 NA 0.52 6.01 0.35 6.19e-9 IgG glycosylation; CESC cis rs1008375 1.000 rs6818639 chr4:17633049 A/G cg16339924 chr4:17578868 LAP3 0.56 7.13 0.4 9.83e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4481887 0.893 rs10888355 chr1:248457180 G/A cg00666640 chr1:248458726 OR2T12 0.4 6.62 0.38 1.97e-10 Common traits (Other); CESC trans rs9329221 0.506 rs17689674 chr8:9981854 C/A cg06636001 chr8:8085503 FLJ10661 0.49 6.06 0.35 4.59e-9 Neuroticism; CESC cis rs17401966 1.000 rs11578788 chr1:10422958 A/G cg15208524 chr1:10270712 KIF1B 0.49 6.21 0.36 2.06e-9 Hepatocellular carcinoma; CESC cis rs826838 0.900 rs9739128 chr12:38948960 A/T cg26384229 chr12:38710491 ALG10B 0.82 14.8 0.67 1.54e-36 Heart rate; CESC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg25405998 chr7:65216604 CCT6P1 -0.45 -5.06 -0.3 7.71e-7 Aortic root size; CESC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg24675658 chr1:53192096 ZYG11B -0.67 -9.24 -0.49 8.49e-18 Monocyte count; CESC trans rs11039798 1.000 rs7479655 chr11:48576714 G/T cg15704280 chr7:45808275 SEPT13 0.68 6.45 0.37 5.36e-10 Axial length; CESC cis rs888194 0.677 rs10774696 chr12:109875753 C/T cg19025524 chr12:109796872 NA -0.4 -6.13 -0.35 3.19e-9 Neuroticism; CESC cis rs2929278 0.588 rs1975364 chr15:44150189 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.5 6.38 0.37 7.72e-10 Schizophrenia; CESC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg26668828 chr6:292823 DUSP22 -0.72 -9.68 -0.51 3.54e-19 Menopause (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00429618 chr9:99962350 ZNF322B -0.45 -6.45 -0.37 5.2400000000000005e-10 Gut microbiota (bacterial taxa); CESC cis rs2295359 1.000 rs736197 chr1:67607135 G/T cg03340356 chr1:67600835 NA 0.32 5.46 0.32 1.11e-7 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17449403 chr12:48357323 TMEM106C 0.6 6.73 0.38 1.05e-10 Gut microbiome composition (summer); CESC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg18402987 chr7:1209562 NA 0.75 8.6 0.47 7.24e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7385804 0.761 rs568733 chr7:100311662 G/T cg20848291 chr7:100343083 ZAN 0.47 6.3 0.36 1.24e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs9611519 0.929 rs2064560 chr22:41530040 A/G cg03806693 chr22:41940476 POLR3H -0.58 -5.93 -0.34 9.4e-9 Neuroticism; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg10255097 chr10:114711603 TCF7L2 0.49 6.11 0.35 3.46e-9 Thyroid stimulating hormone; CESC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.87 0.62 9.38e-30 Colonoscopy-negative controls vs population controls; CESC cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg06022373 chr22:39101656 GTPBP1 0.9 14.15 0.66 2.99e-34 Menopause (age at onset); CESC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg05535760 chr7:792225 HEATR2 -0.78 -8.24 -0.45 8.16e-15 Cerebrospinal P-tau181p levels; CESC cis rs7208859 0.623 rs216445 chr17:28933576 A/G cg14008862 chr17:28927542 LRRC37B2 0.73 5.52 0.32 8.23e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7116495 0.609 rs2508860 chr11:71805052 C/T cg10381502 chr11:71823885 C11orf51 1.04 6.47 0.37 4.61e-10 Severe influenza A (H1N1) infection; CESC cis rs611744 0.647 rs615126 chr8:109247619 C/T cg21045802 chr8:109455806 TTC35 0.49 6.06 0.35 4.71e-9 Dupuytren's disease; CESC cis rs2708240 1.000 rs2710139 chr7:147570807 G/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.53 -0.32 7.72e-8 QT interval (drug interaction); CESC cis rs2066819 1.000 rs2306694 chr12:56680636 C/T cg26734620 chr12:56694298 CS -1.07 -6.58 -0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg21724239 chr8:58056113 NA 0.56 5.96 0.34 8.22e-9 Developmental language disorder (linguistic errors); CESC cis rs7116495 1.000 rs6592448 chr11:71670044 C/T cg10381502 chr11:71823885 C11orf51 0.7 6.16 0.35 2.67e-9 Severe influenza A (H1N1) infection; CESC cis rs6540559 0.673 rs17015361 chr1:210018901 C/G cg23283495 chr1:209979779 IRF6 0.48 5.61 0.33 5.1e-8 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22817039 chr5:60628030 ZSWIM6 0.59 6.8 0.39 6.72e-11 Gut microbiome composition (summer); CESC cis rs807669 0.548 rs9605957 chr22:19187375 G/A cg02655711 chr22:19163373 SLC25A1 0.6 9.14 0.49 1.73e-17 Metabolite levels; CESC cis rs7772486 0.790 rs2485632 chr6:146193228 A/G cg05347473 chr6:146136440 FBXO30 0.58 7.45 0.42 1.31e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs66887589 0.967 rs56173225 chr4:120509972 G/A cg09307838 chr4:120376055 NA -0.53 -7.07 -0.4 1.35e-11 Diastolic blood pressure; CESC cis rs72781680 0.611 rs55788848 chr2:24268721 C/T cg06627628 chr2:24431161 ITSN2 -0.65 -6.21 -0.36 2.08e-9 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23260190 chr10:101419318 ENTPD7 0.58 7.08 0.4 1.27e-11 Gut microbiome composition (summer); CESC cis rs863345 0.967 rs10797016 chr1:158468413 T/C cg12129480 chr1:158549410 OR10X1 -0.31 -6.23 -0.36 1.78e-9 Pneumococcal bacteremia; CESC cis rs763121 0.853 rs8140617 chr22:38970439 A/G cg06544989 chr22:39130855 UNC84B -0.47 -7.47 -0.42 1.17e-12 Menopause (age at onset); CESC cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg03060546 chr3:49711283 APEH 0.5 6.03 0.35 5.57e-9 Parkinson's disease; CESC cis rs17818399 0.547 rs7607308 chr2:46759104 T/C cg02822958 chr2:46747628 ATP6V1E2 0.44 5.34 0.31 1.97e-7 Height; CESC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs2742234 0.590 rs2075912 chr10:43622217 T/C cg07801480 chr10:43725741 RASGEF1A 0.4 5.2 0.3 4e-7 Hirschsprung disease; CESC cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg23978390 chr7:1156363 C7orf50 0.67 6.57 0.37 2.64e-10 Bronchopulmonary dysplasia; CESC cis rs483180 0.512 rs1163251 chr1:120209755 T/C cg19096424 chr1:120255104 PHGDH -0.43 -5.24 -0.31 3.26e-7 Macular telangiectasia type 2; CESC cis rs12824058 0.831 rs11608406 chr12:130805866 G/C cg24838063 chr12:130822603 PIWIL1 0.6 8.01 0.44 3.7e-14 Menopause (age at onset); CESC trans rs61148964 0.826 rs11913459 chr22:37228603 G/A cg26037026 chr7:1641922 NA 0.53 6.15 0.35 2.88e-9 Scarlet fever; CESC cis rs3857536 0.776 rs9363560 chr6:66949686 T/G cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg27347728 chr4:17578864 LAP3 0.43 5.11 0.3 6.18e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg05313129 chr8:58192883 C8orf71 -0.53 -5.27 -0.31 2.86e-7 Developmental language disorder (linguistic errors); CESC cis rs2651899 0.934 rs10909887 chr1:3087373 A/T cg07622451 chr1:3079886 PRDM16 -0.31 -5.41 -0.32 1.43e-7 Migraine; CESC cis rs782590 0.783 rs7594279 chr2:55812073 T/G cg18811423 chr2:55921094 PNPT1 0.8 12.72 0.62 2.9e-29 Metabolic syndrome; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25356086 chr21:33764900 C21orf119;URB1 -0.5 -7.19 -0.4 6.69e-12 Gambling; CESC cis rs4835473 0.712 rs12498218 chr4:144658053 A/G cg25736465 chr4:144833511 NA -0.33 -5.11 -0.3 6.26e-7 Immature fraction of reticulocytes; CESC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg05564831 chr3:52568323 NT5DC2 0.44 6.76 0.38 8.84e-11 Bipolar disorder; CESC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg23758822 chr17:41437982 NA 1.04 15.71 0.69 9.05e-40 Menopause (age at onset); CESC cis rs2204008 0.539 rs2703682 chr12:38107969 A/G cg26384229 chr12:38710491 ALG10B 0.41 5.43 0.32 1.25e-7 Bladder cancer; CESC cis rs941408 0.515 rs878893 chr19:2781325 A/G cg06609049 chr19:2785107 THOP1 0.95 14.55 0.67 1.16e-35 Total cholesterol levels; CESC cis rs2011503 1.000 rs2916070 chr19:19524105 C/T cg11584989 chr19:19387371 SF4 0.59 6.62 0.38 1.95e-10 Bipolar disorder; CESC cis rs4523957 0.671 rs12103726 chr17:2192839 C/T cg16513277 chr17:2031491 SMG6 -0.49 -5.65 -0.33 4.2e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6964587 0.869 rs7810391 chr7:91520227 G/A cg17063962 chr7:91808500 NA -0.53 -6.97 -0.39 2.58e-11 Breast cancer; CESC cis rs9911578 0.817 rs304264 chr17:56749628 A/G cg12560992 chr17:57184187 TRIM37 0.93 15.07 0.68 1.7e-37 Intelligence (multi-trait analysis); CESC cis rs2204008 0.837 rs4312131 chr12:38181087 G/T cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs9400271 0.632 rs9398191 chr6:109586561 C/T cg01475377 chr6:109611718 NA -0.46 -7.21 -0.4 5.96e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs72781680 0.756 rs2551337 chr2:24006886 C/T cg08917208 chr2:24149416 ATAD2B 0.7 6.76 0.38 8.54e-11 Lymphocyte counts; CESC cis rs12142240 0.698 rs56049453 chr1:46835468 A/G cg10495392 chr1:46806563 NSUN4 0.58 6.24 0.36 1.68e-9 Menopause (age at onset); CESC cis rs11723261 0.582 rs4634177 chr4:136837 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.49 6.36 0.36 8.91e-10 Immune response to smallpox vaccine (IL-6); CESC cis rs7178572 0.568 rs12912050 chr15:77689423 C/T cg22256960 chr15:77711686 NA -0.54 -6.95 -0.39 2.9e-11 Type 2 diabetes; CESC cis rs13108904 0.604 rs11946375 chr4:1313488 T/C cg22903657 chr4:1355424 KIAA1530 -0.36 -5.11 -0.3 6.11e-7 Obesity-related traits; CESC cis rs1832871 0.711 rs62439861 chr6:158700531 A/G cg07165851 chr6:158734300 TULP4 0.59 6.32 0.36 1.08e-9 Height; CESC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg12463550 chr7:65579703 CRCP 0.49 6.26 0.36 1.56e-9 Aortic root size; CESC cis rs3820928 0.845 rs13384342 chr2:227805010 G/A cg11843606 chr2:227700838 RHBDD1 -0.48 -6.39 -0.37 7.55e-10 Pulmonary function; CESC cis rs6541297 1.000 rs4846839 chr1:230284924 A/G cg20703242 chr1:230279135 GALNT2 0.74 11.07 0.56 1.18e-23 Coronary artery disease; CESC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg21963583 chr11:68658836 MRPL21 0.4 5.75 0.33 2.41e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13944219 chr5:65440479 SFRS12 0.58 6.99 0.39 2.28e-11 Gut microbiome composition (summer); CESC cis rs10905065 0.930 rs7096742 chr10:5735648 C/T cg11519256 chr10:5708881 ASB13 0.45 5.87 0.34 1.32e-8 Menopause (age at onset); CESC cis rs6061231 0.556 rs6121571 chr20:60977323 T/G cg22601191 chr20:60968625 CABLES2 0.38 5.18 0.3 4.3e-7 Colorectal cancer; CESC cis rs1401999 0.714 rs7646621 chr3:183640865 A/C cg01324343 chr3:183735012 ABCC5 -0.45 -9.34 -0.5 3.97e-18 Anterior chamber depth; CESC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs2124969 0.562 rs13393480 chr2:161058790 G/T cg03641300 chr2:160917029 PLA2R1 -0.4 -5.76 -0.33 2.36e-8 Waist circumference adjusted for body mass index; CESC cis rs61931739 0.500 rs11836198 chr12:34552782 T/C cg06521331 chr12:34319734 NA -0.36 -5.03 -0.3 9.12e-7 Morning vs. evening chronotype; CESC cis rs9916302 0.904 rs4511574 chr17:37532916 A/G cg15445000 chr17:37608096 MED1 0.36 5.77 0.33 2.18e-8 Glomerular filtration rate (creatinine); CESC cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.9 13.31 0.63 2.68e-31 Platelet count; CESC cis rs3768617 0.510 rs6424889 chr1:183091796 G/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.57 0.64 3.24e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7116495 1.000 rs7124000 chr11:71754338 T/C cg10381502 chr11:71823885 C11orf51 -0.58 -5.16 -0.3 4.75e-7 Severe influenza A (H1N1) infection; CESC cis rs7582720 1.000 rs72926802 chr2:203830228 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs3768617 0.811 rs11590958 chr1:183023636 T/C ch.1.3577855R chr1:183094577 LAMC1 0.66 8.99 0.48 4.82e-17 Fuchs's corneal dystrophy; CESC cis rs4849845 0.925 rs4100690 chr2:121027361 T/G cg24070213 chr2:121070622 NA 0.39 5.04 0.3 8.71e-7 Mean platelet volume; CESC cis rs1348850 0.757 rs2166554 chr2:178455824 A/G cg23306229 chr2:178417860 TTC30B 0.49 6.21 0.36 2.04e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs9325144 0.510 rs6582599 chr12:38715965 T/G cg23762105 chr12:34175262 ALG10 -0.49 -6.38 -0.36 8.01e-10 Morning vs. evening chronotype; CESC cis rs2573652 0.698 rs12916269 chr15:100530216 A/T cg00587665 chr15:100533223 ADAMTS17 0.42 6.79 0.39 7.18e-11 Height; CESC cis rs7659604 1.000 rs28640980 chr4:122664284 T/C cg19671926 chr4:122722719 EXOSC9 -0.44 -5.2 -0.3 4.01e-7 Type 2 diabetes; CESC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg00166722 chr3:10149974 C3orf24 0.47 5.97 0.34 7.56e-9 Alzheimer's disease; CESC cis rs2243480 1.000 rs313813 chr7:65503500 C/T cg12463550 chr7:65579703 CRCP 0.69 5.47 0.32 1.04e-7 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01902939 chr1:54304230 TMEM48 0.58 7.14 0.4 9.06e-12 Gut microbiome composition (summer); CESC cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.42 5.18 0.3 4.38e-7 Eosinophil percentage of white cells; CESC cis rs7998202 0.667 rs282584 chr13:113349819 C/T cg02820901 chr13:113351484 ATP11A -0.52 -5.14 -0.3 5.45e-7 Glycated hemoglobin levels; CESC cis rs3768617 0.811 rs10911233 chr1:183052585 G/A ch.1.3577855R chr1:183094577 LAMC1 0.67 9.27 0.49 6.9e-18 Fuchs's corneal dystrophy; CESC cis rs2228479 0.681 rs10153196 chr16:89967397 A/C cg06558623 chr16:89946397 TCF25 0.55 5.28 0.31 2.71e-7 Skin colour saturation; CESC cis rs2180341 0.961 rs910720 chr6:127619070 T/C cg27446573 chr6:127587934 RNF146 1.08 16.13 0.7 3.14e-41 Breast cancer; CESC cis rs6062302 0.522 rs2297428 chr20:62221766 C/T cg09650180 chr20:62225654 GMEB2 -0.8 -9.04 -0.49 3.38e-17 Glioblastoma; CESC cis rs9875589 0.509 rs6783645 chr3:14024542 T/C cg19554555 chr3:13937349 NA -0.44 -5.69 -0.33 3.33e-8 Ovarian reserve; CESC cis rs6504249 0.893 rs2521827 chr17:62692728 T/G cg02598441 chr17:62777298 LOC146880 -0.48 -5.06 -0.3 7.85e-7 Joint mobility (Beighton score); CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23151353 chr4:100867933 DNAJB14 0.52 6.18 0.35 2.42e-9 Gut microbiome composition (summer); CESC cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg06636001 chr8:8085503 FLJ10661 0.42 5.16 0.3 4.74e-7 Neuroticism; CESC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg24562669 chr7:97807699 LMTK2 0.47 6.52 0.37 3.51e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs7916697 0.520 rs12265247 chr10:70038398 A/G cg06988349 chr10:69991859 ATOH7 0.34 5.29 0.31 2.6e-7 Optic disc area; CESC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg00149659 chr3:10157352 C3orf10 0.77 9.67 0.51 3.91e-19 Alzheimer's disease; CESC cis rs9399137 0.507 rs7761964 chr6:135314265 T/C cg22676075 chr6:135203613 NA 0.53 7.09 0.4 1.22e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7927592 0.913 rs7123564 chr11:68362164 C/T cg20283391 chr11:68216788 NA -0.61 -7.28 -0.41 3.86e-12 Total body bone mineral density; CESC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg21984481 chr17:79567631 NPLOC4 -0.49 -8.04 -0.44 2.97e-14 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19947233 chr4:90032727 TIGD2 0.66 7.09 0.4 1.23e-11 Gut microbiome composition (summer); CESC cis rs9462846 0.959 rs7750915 chr6:42882067 C/T cg05552183 chr6:42928497 GNMT 0.46 5.3 0.31 2.43e-7 Blood protein levels; CESC cis rs9858542 0.953 rs6766131 chr3:49538932 T/C cg07274523 chr3:49395745 GPX1 0.66 8.05 0.44 2.82e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17050100 chr2:27852231 GPN1;CCDC121 0.46 6.21 0.36 2.04e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6088590 0.561 rs2295444 chr20:33173883 C/T cg08999081 chr20:33150536 PIGU 0.7 12.43 0.61 3.03e-28 Coronary artery disease; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg16931877 chr3:32726605 CNOT10 -0.44 -6.53 -0.37 3.41e-10 Breast cancer; CESC cis rs6499255 1.000 rs4580150 chr16:69814953 G/A cg15192750 chr16:69999425 NA 0.46 5.64 0.33 4.46e-8 IgE levels; CESC cis rs6570726 0.791 rs9322029 chr6:145906683 A/G cg23711669 chr6:146136114 FBXO30 0.93 13.88 0.65 2.77e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.4 0.37 7.12e-10 Menopause (age at onset); CESC cis rs12765878 1.000 rs11191843 chr10:105648651 G/C cg24587175 chr10:105670608 OBFC1 0.32 5.22 0.31 3.58e-7 Coronary artery disease; CESC cis rs8133932 0.701 rs2839054 chr21:47328449 A/G cg14185626 chr21:47401492 COL6A1 0.46 5.17 0.3 4.51e-7 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16365729 chr1:244998894 FAM36A -0.45 -6.07 -0.35 4.48e-9 Ulcerative colitis; CESC cis rs34779708 0.931 rs4934721 chr10:35377715 A/G cg03585969 chr10:35415529 CREM 0.78 10.05 0.53 2.38e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs12500824 0.564 rs72657839 chr4:77335916 G/T cg20311846 chr4:77356250 SHROOM3 0.39 7.5 0.42 9.73e-13 Coronary artery disease; CESC cis rs1005277 0.522 rs9418276 chr10:37940116 G/T cg00409905 chr10:38381863 ZNF37A -0.49 -6.68 -0.38 1.4e-10 Extrinsic epigenetic age acceleration; CESC cis rs56399783 0.901 rs56007918 chr7:2826205 A/G cg19731401 chr7:2775893 GNA12 0.64 5.73 0.33 2.67e-8 Childhood ear infection; CESC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg18337363 chr3:52569053 NT5DC2 0.3 5.63 0.33 4.64e-8 Electroencephalogram traits; CESC cis rs8070740 0.891 rs4790264 chr17:5336791 G/T cg25236894 chr17:5323110 RPAIN;NUP88 0.56 6.38 0.36 7.92e-10 Menopause (age at onset); CESC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg03517284 chr6:25882590 NA -0.62 -8.88 -0.48 1.06e-16 Intelligence (multi-trait analysis); CESC cis rs787274 0.867 rs786969 chr9:115449556 C/G cg13803584 chr9:115635662 SNX30 0.68 5.1 0.3 6.49e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.84 0.34 1.51e-8 Bipolar disorder; CESC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg12756686 chr19:29218302 NA 0.56 7.3 0.41 3.44e-12 Methadone dose in opioid dependence; CESC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg06634786 chr22:41940651 POLR3H -0.65 -6.97 -0.39 2.47e-11 Vitiligo; CESC cis rs7771547 0.542 rs597153 chr6:36395997 C/T cg04289385 chr6:36355825 ETV7 0.38 5.57 0.32 6.41e-8 Platelet distribution width; CESC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.65 0.38 1.71e-10 Prudent dietary pattern; CESC cis rs2806561 0.734 rs2806564 chr1:23506685 T/C cg12483005 chr1:23474871 LUZP1 0.39 6.15 0.35 2.85e-9 Height; CESC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg05368731 chr17:41323189 NBR1 0.77 10.63 0.55 3.23e-22 Menopause (age at onset); CESC cis rs854765 0.547 rs2955359 chr17:17946730 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.33 -0.36 1.03e-9 Total body bone mineral density; CESC cis rs1538970 0.924 rs11211117 chr1:45930246 C/T cg06784218 chr1:46089804 CCDC17 0.34 5.45 0.32 1.14e-7 Platelet count; CESC trans rs208520 0.955 rs9453664 chr6:66976079 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 7.87 0.44 9.16e-14 Exhaled nitric oxide output; CESC cis rs7116495 0.609 rs10793014 chr11:71698838 A/G cg07596299 chr11:71824057 C11orf51 -0.85 -5.48 -0.32 9.86e-8 Severe influenza A (H1N1) infection; CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg07628558 chr20:56964831 VAPB 0.48 6.0 0.35 6.36e-9 Obesity-related traits; CESC cis rs7236492 0.748 rs78531995 chr18:77198370 C/T cg15644404 chr18:77186268 NFATC1 -0.69 -5.4 -0.31 1.49e-7 Inflammatory bowel disease;Crohn's disease; CESC trans rs4927850 0.918 rs4361313 chr3:195752260 A/G cg16724585 chr3:197361211 NA -0.56 -7.17 -0.4 7.33e-12 Pancreatic cancer; CESC cis rs2637266 0.739 rs2583040 chr10:78439388 A/C cg18941641 chr10:78392320 NA 0.4 7.32 0.41 2.98e-12 Pulmonary function; CESC cis rs11785400 1.000 rs3735999 chr8:143746069 T/C cg24634471 chr8:143751801 JRK 0.47 6.23 0.36 1.87e-9 Schizophrenia; CESC cis rs3026101 0.671 rs2309372 chr17:5298396 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg11905131 chr22:24372483 LOC391322 -0.8 -12.03 -0.59 7.02e-27 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2932538 0.846 rs7546203 chr1:113154529 C/A cg22162597 chr1:113214053 CAPZA1 0.59 7.46 0.42 1.28e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02520729 chr12:122261552 SETD1B 0.5 6.59 0.38 2.3e-10 Fibrinogen levels; CESC cis rs757110 0.866 rs5215 chr11:17408630 C/T cg11839944 chr11:17409644 KCNJ11 0.41 5.38 0.31 1.67e-7 Type 2 diabetes; CESC cis rs7395581 0.918 rs3816725 chr11:47305669 T/G cg25783544 chr11:47291846 MADD 0.61 8.12 0.45 1.74e-14 HDL cholesterol; CESC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.26 -0.31 2.92e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7917772 0.503 rs7896841 chr10:104294665 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -6.02 -0.35 5.75e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs919433 0.926 rs787996 chr2:198216805 A/G cg10820045 chr2:198174542 NA 0.39 5.78 0.33 2.05e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs8050907 0.744 rs17887050 chr16:4524584 C/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.89 5.66 0.33 3.84e-8 Obesity-related traits; CESC cis rs943466 0.513 rs755497 chr6:33734419 C/T cg25922239 chr6:33757077 LEMD2 -0.43 -5.68 -0.33 3.56e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; CESC cis rs10927875 0.562 rs10803401 chr1:16147377 G/A cg05821634 chr1:16164109 FLJ37453 0.35 5.04 0.3 8.7e-7 Dilated cardiomyopathy; CESC cis rs892961 0.867 rs6501955 chr17:75414443 A/G cg05865280 chr17:75406074 SEPT9 0.63 12.75 0.62 2.36e-29 Airflow obstruction; CESC cis rs796364 0.951 rs13029537 chr2:200998950 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.78 -0.38 7.71e-11 Schizophrenia; CESC cis rs6800768 0.633 rs57144868 chr3:24144965 G/C cg10674438 chr3:24145617 LOC152024 -0.46 -6.19 -0.36 2.23e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2637266 0.935 rs751770 chr10:78393956 A/G cg18941641 chr10:78392320 NA 0.43 8.09 0.45 2.14e-14 Pulmonary function; CESC cis rs17401966 0.838 rs1538557 chr1:10297230 T/C cg15208524 chr1:10270712 KIF1B 0.4 5.24 0.31 3.33e-7 Hepatocellular carcinoma; CESC cis rs9303401 0.538 rs12603174 chr17:56489279 T/C cg25039879 chr17:56429692 SUPT4H1 0.6 6.33 0.36 1.05e-9 Cognitive test performance; CESC trans rs7980799 0.649 rs1601003 chr12:33689436 A/T cg26384229 chr12:38710491 ALG10B 0.55 7.85 0.43 1.05e-13 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs17125944 0.506 rs7151491 chr14:53313711 C/G cg00686598 chr14:53173677 PSMC6 -0.56 -5.09 -0.3 6.79e-7 Alzheimer's disease (late onset); CESC cis rs13242816 1.000 rs62471198 chr7:116107963 T/C cg04696780 chr7:116139425 CAV2 -0.62 -5.69 -0.33 3.31e-8 P wave duration; CESC cis rs61542988 0.532 rs12673996 chr7:22833400 C/T cg13679077 chr7:22862647 TOMM7 0.48 5.62 0.33 4.92e-8 Fibrinogen levels; CESC cis rs6973256 0.569 rs13246174 chr7:133395004 C/T cg10665199 chr7:133106180 EXOC4 0.44 6.0 0.35 6.41e-9 Intelligence (multi-trait analysis); CESC cis rs2276314 0.857 rs16967327 chr18:33587036 C/T cg05985134 chr18:33552581 C18orf21 0.61 7.24 0.41 4.75e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7772486 0.875 rs2814876 chr6:146304030 C/T cg05347473 chr6:146136440 FBXO30 0.56 7.33 0.41 2.74e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7914558 0.966 rs2297786 chr10:104679978 C/T cg04362960 chr10:104952993 NT5C2 0.43 5.52 0.32 8.02e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg17949981 chr6:28129498 ZNF389 0.46 5.51 0.32 8.48e-8 Depression; CESC cis rs6752107 1.000 rs6431654 chr2:234161769 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.39 6.04 0.35 5.27e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs2425143 1.000 rs6058325 chr20:34388806 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 7.72e-12 Blood protein levels; CESC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg18404041 chr3:52824283 ITIH1 -0.38 -6.45 -0.37 5.31e-10 Electroencephalogram traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08722104 chr11:47448306 PSMC3 0.45 6.0 0.35 6.56e-9 Gut microbiota (bacterial taxa); CESC cis rs10465746 0.687 rs6576954 chr1:84323701 C/T cg10977910 chr1:84465055 TTLL7 -0.43 -5.54 -0.32 7.13e-8 Obesity-related traits; CESC cis rs722599 0.961 rs2359239 chr14:75326771 C/T cg11812906 chr14:75593930 NEK9 -0.4 -5.08 -0.3 7.29e-7 IgG glycosylation; CESC cis rs6076065 1.000 rs2424547 chr20:23392690 A/G cg12062639 chr20:23401060 NAPB 0.42 5.17 0.3 4.64e-7 Facial morphology (factor 15, philtrum width); CESC cis rs763014 0.898 rs1981484 chr16:630710 A/G cg00908189 chr16:619842 PIGQ 0.66 9.26 0.49 7.42e-18 Height; CESC cis rs7178909 0.732 rs57163265 chr15:90400650 A/T cg19708238 chr15:90437601 AP3S2 0.38 5.09 0.3 6.64e-7 Common traits (Other); CESC cis rs4803468 1.000 rs13344563 chr19:41945904 G/C cg14132834 chr19:41945861 ATP5SL 0.6 7.5 0.42 9.48e-13 Height; CESC cis rs36715 1.000 rs36702 chr5:127552723 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.55 6.3 0.36 1.23e-9 Breast cancer; CESC cis rs7267979 0.745 rs6132845 chr20:25547767 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.7 11.61 0.58 1.77e-25 Liver enzyme levels (alkaline phosphatase); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09378111 chr2:211036309 C2orf67 0.48 6.08 0.35 4.13e-9 Gut microbiota (bacterial taxa); CESC cis rs9837602 1.000 rs13069311 chr3:99801628 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.51 7.05 0.4 1.55e-11 Breast cancer; CESC cis rs684232 0.666 rs425961 chr17:573714 G/A cg12384639 chr17:618140 VPS53 0.4 5.14 0.3 5.27e-7 Prostate cancer; CESC cis rs9549367 0.713 rs2476328 chr13:113829350 C/T cg18105134 chr13:113819100 PROZ 0.57 7.02 0.4 1.89e-11 Platelet distribution width; CESC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg13206674 chr6:150067644 NUP43 0.45 6.48 0.37 4.57e-10 Lung cancer; CESC cis rs1707322 0.827 rs12125508 chr1:46246010 A/G cg03146154 chr1:46216737 IPP 0.8 11.14 0.56 6.98e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg02428538 chr16:24856791 SLC5A11 -0.48 -5.05 -0.3 8.04e-7 Intelligence (multi-trait analysis); CESC cis rs9914544 0.933 rs11871889 chr17:18771425 T/C cg26378065 chr17:18585709 ZNF286B 0.45 5.54 0.32 7.46e-8 Educational attainment (years of education); CESC cis rs4253772 0.530 rs9615955 chr22:46743931 A/G cg00784671 chr22:46762841 CELSR1 -0.65 -6.19 -0.36 2.31e-9 LDL cholesterol;Cholesterol, total; CESC cis rs8020095 0.571 rs2144909 chr14:67325444 G/C cg19548862 chr14:67692701 FAM71D -0.49 -5.94 -0.34 8.74e-9 Depression (quantitative trait); CESC cis rs57506017 0.585 rs10950395 chr7:12264467 T/C cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.37e-7 Neuroticism; CESC cis rs7809950 1.000 rs7793613 chr7:107250484 C/T cg23024343 chr7:107201750 COG5 -0.43 -5.93 -0.34 9.53e-9 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07949612 chr2:69664562 NFU1 -0.45 -6.28 -0.36 1.41e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4268898 0.662 rs2891380 chr2:24525830 G/A cg08917208 chr2:24149416 ATAD2B 0.51 5.14 0.3 5.27e-7 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04453488 chr8:145619577 CPSF1;MIR939 -0.49 -6.29 -0.36 1.33e-9 Gut microbiome composition (summer); CESC cis rs317689 0.513 rs317659 chr12:69686132 T/A cg20891283 chr12:69753455 YEATS4 0.58 7.3 0.41 3.45e-12 Response to diuretic therapy; CESC cis rs4523957 0.928 rs216202 chr17:2197387 T/C cg16513277 chr17:2031491 SMG6 0.6 8.31 0.45 5.14e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs854765 0.927 rs12943914 chr17:17980671 A/G cg16928487 chr17:17741425 SREBF1 -0.51 -8.45 -0.46 2.01e-15 Total body bone mineral density; CESC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg07677032 chr17:61819896 STRADA 0.49 6.42 0.37 6.41e-10 Prudent dietary pattern; CESC cis rs35110281 0.641 rs4818861 chr21:45123807 A/G cg04455712 chr21:45112962 RRP1B 0.49 7.1 0.4 1.16e-11 Mean corpuscular volume; CESC cis rs2742417 0.624 rs2673068 chr3:45768981 G/A cg04837898 chr3:45731254 SACM1L -0.48 -6.28 -0.36 1.4e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs5769765 0.954 rs5770709 chr22:50245196 G/T cg22709217 chr22:50311962 ALG12;CRELD2 0.47 5.44 0.32 1.18e-7 Schizophrenia; CESC cis rs897984 0.762 rs7206511 chr16:30950352 G/A cg02466173 chr16:30829666 NA 0.48 8.01 0.44 3.58e-14 Dementia with Lewy bodies; CESC cis rs1707322 0.721 rs11211157 chr1:46132844 T/C cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20972342 chr5:235327 SDHA 0.43 6.12 0.35 3.38e-9 Fibrinogen levels; CESC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg17372223 chr3:52568218 NT5DC2 0.42 6.29 0.36 1.32e-9 Bipolar disorder; CESC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg16325326 chr1:53192061 ZYG11B -0.73 -12.08 -0.6 4.76e-27 Monocyte count; CESC cis rs11997175 0.603 rs7016580 chr8:33824135 G/A ch.8.33884649F chr8:33765107 NA 0.49 5.84 0.34 1.53e-8 Body mass index; CESC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.6 -0.33 5.49e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27056436 chr7:5569463 ACTB 0.57 6.69 0.38 1.33e-10 Gut microbiome composition (summer); CESC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg00815214 chr21:47717953 NA -0.35 -5.17 -0.3 4.58e-7 Testicular germ cell tumor; CESC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 10.34 0.54 2.91e-21 Platelet count; CESC cis rs9287719 0.967 rs6755548 chr2:10746126 A/G cg00105475 chr2:10696890 NA 0.38 5.55 0.32 6.76e-8 Prostate cancer; CESC cis rs7666738 0.830 rs35685312 chr4:98858521 G/A cg05340658 chr4:99064831 C4orf37 0.75 11.16 0.57 5.89e-24 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.686 rs3014236 chr1:46091305 T/C cg05343316 chr1:45956843 TESK2 -0.52 -6.4 -0.37 7.03e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9549260 0.755 rs9549252 chr13:41230141 A/G cg21288729 chr13:41239152 FOXO1 0.55 6.78 0.38 7.64e-11 Red blood cell count; CESC cis rs7091068 0.671 rs591392 chr10:95406081 G/A cg20715218 chr10:95462985 C10orf4 -0.54 -5.76 -0.33 2.31e-8 Urinary tract infection frequency; CESC cis rs56235845 0.694 rs6876677 chr5:176755342 T/C cg17509989 chr5:176798049 RGS14 0.51 6.56 0.37 2.76e-10 Hemoglobin concentration;Hematocrit; CESC cis rs7084402 0.515 rs12262629 chr10:60265656 G/A cg07615347 chr10:60278583 BICC1 -0.56 -7.97 -0.44 4.75e-14 Refractive error; CESC cis rs6426558 0.621 rs7521639 chr1:227223736 T/C cg10327440 chr1:227177885 CDC42BPA 0.83 11.74 0.58 6.81e-26 Neutrophil percentage of white cells; CESC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg07870213 chr5:140052090 DND1 0.64 6.87 0.39 4.48e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg02543249 chr2:176867176 KIAA1715 0.51 6.25 0.36 1.66e-9 Thyroid stimulating hormone; CESC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.09 21.15 0.79 7.85e-59 Prudent dietary pattern; CESC cis rs950169 0.922 rs8037078 chr15:84818871 A/G cg17507749 chr15:85114479 UBE2QP1 -0.55 -6.25 -0.36 1.66e-9 Schizophrenia; CESC cis rs10088262 0.527 rs3911939 chr8:124793744 T/G cg15047889 chr8:124780837 FAM91A1 -0.55 -6.67 -0.38 1.49e-10 Pancreatic cancer; CESC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg08470875 chr2:26401718 FAM59B -0.47 -5.29 -0.31 2.56e-7 Gut microbiome composition (summer); CESC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg10053473 chr17:62856997 LRRC37A3 0.67 9.22 0.49 9.43e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9303401 0.659 rs12935851 chr17:56600244 C/A cg10487724 chr17:56770010 TEX14;RAD51C 1.03 12.7 0.62 3.54e-29 Cognitive test performance; CESC cis rs9463078 0.739 rs1293467 chr6:44769204 C/G cg25276700 chr6:44698697 NA 0.34 5.2 0.3 4.04e-7 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs11098499 0.863 rs3775844 chr4:120428033 G/A cg24375607 chr4:120327624 NA 0.44 5.23 0.31 3.48e-7 Corneal astigmatism; CESC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg05025164 chr4:1340916 KIAA1530 -0.64 -8.8 -0.48 1.8e-16 Obesity-related traits; CESC cis rs7940866 0.834 rs10894298 chr11:130840571 C/A cg12179176 chr11:130786555 SNX19 0.66 10.11 0.53 1.52e-20 Schizophrenia; CESC cis rs2637266 0.703 rs2583061 chr10:78558475 G/A cg18941641 chr10:78392320 NA 0.4 7.53 0.42 7.91e-13 Pulmonary function; CESC cis rs868036 0.718 rs3784710 chr15:68072458 T/C cg03210257 chr15:68118127 LBXCOR1 -0.28 -5.11 -0.3 6.25e-7 Restless legs syndrome; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T ch.6.215100R chr6:7903714 TXNDC5 -0.45 -6.21 -0.36 2.09e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs854765 0.520 rs7219324 chr17:17909775 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.51 -6.71 -0.38 1.15e-10 Total body bone mineral density; CESC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg17724175 chr1:150552817 MCL1 0.33 5.23 0.31 3.49e-7 Tonsillectomy; CESC cis rs11158198 0.643 rs7151771 chr14:58580310 C/T cg15908186 chr14:58618357 C14orf37 0.35 5.09 0.3 6.67e-7 Dementia and core Alzheimer's disease neuropathologic changes; CESC trans rs55704346 0.566 rs9991246 chr4:25385320 T/C cg01822600 chr1:245751692 KIF26B 0.43 6.27 0.36 1.44e-9 Tonsillectomy; CESC cis rs72781680 0.898 rs72782106 chr2:24022009 A/G cg08917208 chr2:24149416 ATAD2B 1.13 10.18 0.53 9.42e-21 Lymphocyte counts; CESC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg18190219 chr22:46762943 CELSR1 -0.66 -7.03 -0.4 1.72e-11 LDL cholesterol;Cholesterol, total; CESC cis rs4986172 0.726 rs12946454 chr17:43208121 A/T cg10701640 chr17:43249399 NA 0.39 6.13 0.35 3.25e-9 Height; CESC cis rs8114671 0.836 rs13042358 chr20:33634479 G/A cg24642439 chr20:33292090 TP53INP2 -0.45 -5.44 -0.32 1.19e-7 Height; CESC cis rs6912958 0.754 rs10755484 chr6:88244648 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.5 -0.37 3.99e-10 Monocyte percentage of white cells; CESC trans rs7617773 0.817 rs3731534 chr3:48211777 C/T cg02094337 chr17:80542118 FOXK2 0.43 6.17 0.35 2.5e-9 Coronary artery disease; CESC cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg00033643 chr7:134001901 SLC35B4 0.41 5.23 0.31 3.38e-7 Mean platelet volume; CESC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.95 10.19 0.53 8.92e-21 Platelet count; CESC cis rs763121 0.962 rs5757130 chr22:38937794 G/A cg06544989 chr22:39130855 UNC84B 0.44 7.89 0.44 8.13e-14 Menopause (age at onset); CESC cis rs116095464 0.558 rs6881920 chr5:222411 T/C cg10591111 chr5:226296 SDHA -0.51 -6.35 -0.36 9.22e-10 Breast cancer; CESC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.15 0.4 8.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs72634258 0.732 rs6577464 chr1:8171302 T/C cg00042356 chr1:8021962 PARK7 -0.52 -5.64 -0.33 4.36e-8 Inflammatory bowel disease; CESC cis rs8077889 0.672 rs1230397 chr17:41844689 A/G cg26893861 chr17:41843967 DUSP3 1.09 22.94 0.82 7.04e-65 Triglycerides; CESC cis rs7100689 0.646 rs1290317 chr10:82062531 C/A cg00277334 chr10:82204260 NA -0.61 -8.08 -0.44 2.35e-14 Post bronchodilator FEV1; CESC trans rs931812 1.000 rs931812 chr8:101919321 A/G cg20993868 chr7:22813445 NA -0.44 -6.17 -0.35 2.51e-9 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg02038168 chr22:39784481 NA -0.62 -7.66 -0.43 3.51e-13 Intelligence (multi-trait analysis); CESC cis rs57506017 0.585 rs6460899 chr7:12253050 A/C cg23422036 chr7:12250390 TMEM106B 0.39 5.21 0.3 3.76e-7 Neuroticism; CESC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg23048001 chr7:2026167 MAD1L1 0.45 5.72 0.33 2.84e-8 Schizophrenia; CESC cis rs11997175 0.902 rs7009022 chr8:33700404 A/G ch.8.33884649F chr8:33765107 NA 0.61 7.89 0.44 8.22e-14 Body mass index; CESC cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg02297831 chr4:17616191 MED28 0.66 8.05 0.44 2.75e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs12410462 0.581 rs35141785 chr1:227553496 G/C cg10327440 chr1:227177885 CDC42BPA -0.62 -5.2 -0.3 3.97e-7 Major depressive disorder; CESC cis rs9318086 0.935 rs9652080 chr13:24435426 A/C cg25267304 chr13:24462978 PCOTH;MIPEP -0.39 -5.31 -0.31 2.3e-7 Myopia (pathological); CESC cis rs9611565 0.765 rs132906 chr22:41799767 G/C cg06634786 chr22:41940651 POLR3H 0.44 5.15 0.3 5.08e-7 Vitiligo; CESC cis rs4969178 0.600 rs4969184 chr17:76393413 G/A cg05887092 chr17:76393375 PGS1 0.69 11.47 0.58 5.36e-25 HDL cholesterol levels; CESC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg13733410 chr7:12443478 VWDE -0.53 -5.45 -0.32 1.17e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07272677 chr4:186741447 SORBS2 -0.53 -6.04 -0.35 5.22e-9 Gut microbiome composition (summer); CESC cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.45 5.86 0.34 1.4e-8 Personality dimensions; CESC cis rs1670533 0.929 rs6599280 chr4:1063818 A/G cg27284194 chr4:1044797 NA 0.47 5.83 0.34 1.57e-8 Recombination rate (females); CESC cis rs12142240 0.698 rs72677594 chr1:46824371 A/C cg00530320 chr1:46809349 NSUN4 0.6 8.04 0.44 2.96e-14 Menopause (age at onset); CESC cis rs2629540 0.793 rs10794180 chr10:126449306 T/A cg08799069 chr10:126477246 METTL10 -0.67 -9.16 -0.49 1.44e-17 Cocaine dependence; CESC cis rs4728302 0.574 rs7804463 chr7:133447651 T/C cg10665199 chr7:133106180 EXOC4 0.42 5.64 0.33 4.35e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs3738443 0.594 rs60050650 chr1:247376776 T/C cg07706540 chr1:247373924 NA -0.46 -5.45 -0.32 1.15e-7 Alcohol dependence; CESC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg17949981 chr6:28129498 ZNF389 0.42 5.17 0.3 4.72e-7 Depression; CESC cis rs2901656 0.502 rs9425308 chr1:172383265 A/C cg03748243 chr1:172413542 C1orf105;PIGC 0.38 5.16 0.3 4.75e-7 Red cell distribution width;Platelet distribution width; CESC trans rs561341 0.831 rs11658469 chr17:30206426 T/C cg20587970 chr11:113659929 NA 0.99 11.72 0.58 7.58e-26 Hip circumference adjusted for BMI; CESC cis rs13256369 0.802 rs2280560 chr8:8560602 C/T cg17143192 chr8:8559678 CLDN23 0.76 8.64 0.47 5.49e-16 Obesity-related traits; CESC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -6.87 -0.39 4.63e-11 Personality dimensions; CESC cis rs453301 0.624 rs2979265 chr8:8858717 G/C cg06636001 chr8:8085503 FLJ10661 0.45 5.93 0.34 9.22e-9 Joint mobility (Beighton score); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12598099 chr18:60189407 ZCCHC2 -0.61 -7.22 -0.41 5.42e-12 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg18230493 chr5:56204884 C5orf35 -0.74 -8.73 -0.47 2.85e-16 Initial pursuit acceleration; CESC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg16278512 chr7:12443529 VWDE -0.52 -6.47 -0.37 4.63e-10 Coronary artery disease; CESC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg27535305 chr1:53392650 SCP2 -0.31 -5.4 -0.31 1.5e-7 Monocyte count; CESC trans rs11098499 0.863 rs6534139 chr4:120449456 A/G cg25214090 chr10:38739885 LOC399744 -0.68 -8.98 -0.48 5.25e-17 Corneal astigmatism; CESC cis rs6429082 0.683 rs868815 chr1:235584543 C/G cg26050004 chr1:235667680 B3GALNT2 -0.54 -6.76 -0.38 8.66e-11 Adiposity; CESC cis rs72781680 0.848 rs6748727 chr2:24041058 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs3824867 0.920 rs7108143 chr11:47453722 T/G cg20307385 chr11:47447363 PSMC3 -0.49 -5.9 -0.34 1.12e-8 Mean corpuscular hemoglobin; CESC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg25767906 chr1:53392781 SCP2 0.43 5.85 0.34 1.42e-8 Monocyte count; CESC cis rs965469 0.779 rs6037548 chr20:3299299 G/A cg25506879 chr20:3388711 C20orf194 -0.49 -5.41 -0.32 1.44e-7 IFN-related cytopenia; CESC cis rs10751667 0.600 rs10751665 chr11:941300 G/A cg06064525 chr11:970664 AP2A2 -0.52 -10.43 -0.54 1.43e-21 Alzheimer's disease (late onset); CESC cis rs17376456 0.877 rs35075119 chr5:93385457 T/C cg21475434 chr5:93447410 FAM172A 0.77 6.93 0.39 3.23e-11 Diabetic retinopathy; CESC cis rs11155671 0.530 rs4869764 chr6:150211828 T/C cg09699651 chr6:150184138 LRP11 0.55 7.7 0.43 2.78e-13 Testicular germ cell tumor; CESC cis rs11249608 0.548 rs12152869 chr5:178462520 A/G cg21905437 chr5:178450457 ZNF879 0.58 8.1 0.45 2.04e-14 Pubertal anthropometrics; CESC cis rs7193541 0.646 rs4888267 chr16:74687906 A/G cg01733217 chr16:74700730 RFWD3 1.05 20.16 0.78 2e-55 Multiple myeloma; CESC cis rs1808579 0.935 rs1623060 chr18:21143183 C/T cg14672496 chr18:21087552 C18orf8 0.38 5.43 0.32 1.29e-7 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs7927592 0.763 rs10791982 chr11:68337664 T/G cg01657329 chr11:68192670 LRP5 0.5 6.72 0.38 1.11e-10 Total body bone mineral density; CESC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg05368731 chr17:41323189 NBR1 0.71 8.2 0.45 1.06e-14 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07970400 chr15:40650285 DISP2 -0.43 -6.08 -0.35 4.07e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3806843 0.735 rs801183 chr5:140091115 C/T cg26395211 chr5:140044315 WDR55 -0.47 -6.16 -0.35 2.68e-9 Depressive symptoms (multi-trait analysis); CESC cis rs829883 0.646 rs1641638 chr12:98891031 A/G cg25150519 chr12:98850993 NA 0.41 5.34 0.31 2.01e-7 Colorectal adenoma (advanced); CESC cis rs6831352 0.879 rs2851255 chr4:100042103 C/G cg12011299 chr4:100065546 ADH4 0.52 5.9 0.34 1.11e-8 Alcohol dependence; CESC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.6 -0.42 4.99e-13 Gut microbiome composition (summer); CESC cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg16262614 chr3:133464971 TF 0.4 7.96 0.44 4.99e-14 Iron status biomarkers (transferrin levels); CESC cis rs9549367 0.789 rs6577031 chr13:113878182 T/C cg18105134 chr13:113819100 PROZ 0.62 8.25 0.45 7.66e-15 Platelet distribution width; CESC cis rs1483890 0.723 rs6783070 chr3:69411596 A/C cg22125112 chr3:69402811 FRMD4B -0.39 -5.24 -0.31 3.26e-7 Resting heart rate; CESC cis rs80130819 0.688 rs11168455 chr12:48592792 G/A cg05342945 chr12:48394962 COL2A1 -0.53 -6.1 -0.35 3.76e-9 Prostate cancer; CESC cis rs902774 0.597 rs7299694 chr12:53352572 A/C cg16329197 chr12:53359506 NA -0.54 -7.74 -0.43 2.15e-13 Prostate cancer; CESC cis rs698833 0.501 rs10194161 chr2:44507213 A/G cg04920474 chr2:44395004 PPM1B -0.46 -6.7 -0.38 1.25e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22506413 chr7:54902079 NA -0.42 -6.15 -0.35 2.86e-9 Gut microbiota (bacterial taxa); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04025244 chr7:32766748 LOC441208 -0.36 -6.09 -0.35 3.89e-9 Gambling; CESC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg22823121 chr1:150693482 HORMAD1 0.4 5.64 0.33 4.46e-8 Melanoma; CESC cis rs12142240 0.698 rs10158236 chr1:46820896 G/T cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC cis rs7216064 1.000 rs62084249 chr17:65874998 A/G cg07042672 chr17:66097459 LOC651250 -0.52 -5.4 -0.31 1.5e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg17775713 chr3:133465469 TF 0.34 6.03 0.35 5.54e-9 Iron status biomarkers (transferrin levels); CESC cis rs7264396 0.528 rs7273880 chr20:34551507 A/G cg17201900 chr20:34330562 RBM39 0.5 5.22 0.31 3.71e-7 Total cholesterol levels; CESC cis rs938554 0.578 rs7663032 chr4:9993838 C/T cg02734326 chr4:10020555 SLC2A9 0.45 5.42 0.32 1.35e-7 Blood metabolite levels; CESC cis rs72781680 1.000 rs12623496 chr2:24181583 C/T cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs10883723 0.962 rs1056740 chr10:104236552 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.67 -0.33 3.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs644799 0.687 rs3748252 chr11:95519195 A/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.76 -10.68 -0.55 2.2e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7267979 1.000 rs2424712 chr20:25416942 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.87 18.11 0.74 3e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs34779708 0.733 rs12254018 chr10:35550641 T/A cg03585969 chr10:35415529 CREM 0.54 6.14 0.35 2.97e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs734999 0.588 rs10910098 chr1:2533250 C/A cg18854424 chr1:2615690 NA 0.28 5.41 0.32 1.43e-7 Ulcerative colitis; CESC cis rs3796352 1.000 rs4478072 chr3:53106125 G/T cg07884673 chr3:53033167 SFMBT1 0.53 5.3 0.31 2.47e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg17747265 chr1:1875780 NA -0.58 -9.2 -0.49 1.14e-17 Body mass index; CESC trans rs1814175 0.616 rs1722001 chr11:49894427 A/G cg03929089 chr4:120376271 NA -0.9 -14.75 -0.67 2.44e-36 Height; CESC cis rs7659604 0.521 rs4833235 chr4:122695136 C/A cg20573242 chr4:122745356 CCNA2 -0.39 -5.03 -0.3 8.9e-7 Type 2 diabetes; CESC cis rs2066819 1.000 rs77131854 chr12:56664231 C/T cg26734620 chr12:56694298 CS 1.04 6.71 0.38 1.18e-10 Psoriasis vulgaris; CESC cis rs6088580 0.634 rs6088484 chr20:32985961 T/C cg08999081 chr20:33150536 PIGU -0.65 -11.34 -0.57 1.5e-24 Glomerular filtration rate (creatinine); CESC cis rs9300255 0.602 rs1106241 chr12:123627016 T/C cg19016782 chr12:123741754 C12orf65 -0.37 -5.07 -0.3 7.56e-7 Neutrophil percentage of white cells; CESC cis rs765787 0.530 rs2413785 chr15:45530381 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -7.3 -0.41 3.34e-12 Uric acid levels; CESC cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg06636001 chr8:8085503 FLJ10661 0.43 5.28 0.31 2.66e-7 Red cell distribution width; CESC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg24675658 chr1:53192096 ZYG11B 0.74 11.37 0.57 1.15e-24 Monocyte count; CESC cis rs7512552 0.839 rs834231 chr1:150389392 A/T cg15654264 chr1:150340011 RPRD2 -0.42 -5.63 -0.33 4.48e-8 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC trans rs61931739 0.517 rs7486246 chr12:34526419 T/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 8.03e-13 Morning vs. evening chronotype; CESC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.99 -12.0 -0.59 8.9e-27 Gut microbiome composition (summer); CESC cis rs9419702 0.614 rs9419567 chr10:133535149 C/G cg04492858 chr10:133558786 NA 0.39 5.52 0.32 7.87e-8 Survival in rectal cancer; CESC cis rs4073582 0.555 rs521109 chr11:66030948 G/A cg14036092 chr11:66035641 RAB1B 0.56 7.87 0.44 9.14e-14 Gout; CESC cis rs2569991 0.588 rs14191 chr3:12940346 G/A cg22481960 chr3:13008800 IQSEC1 -0.57 -6.76 -0.38 8.53e-11 Periodontitis (DPAL); CESC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg17650747 chr5:1873721 NA 0.43 6.1 0.35 3.77e-9 Cardiovascular disease risk factors; CESC cis rs6577655 0.517 rs6996991 chr8:135589255 G/A cg17885191 chr8:135476712 NA 0.47 5.24 0.31 3.26e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs7508679 1.000 rs10401485 chr19:7222234 T/C cg09779027 chr19:7224513 INSR 0.53 8.58 0.47 7.92e-16 Hypothyroidism; CESC cis rs7582720 1.000 rs75869289 chr2:203806724 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs11997175 0.766 rs6983113 chr8:33699513 G/A ch.8.33884649F chr8:33765107 NA 0.44 5.61 0.33 5.22e-8 Body mass index; CESC cis rs2404602 0.692 rs58361452 chr15:76973372 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.15 -0.3 5.13e-7 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13402217 chr1:151584375 SNX27 0.61 7.56 0.42 6.81e-13 Gut microbiome composition (summer); CESC cis rs9322193 0.962 rs9322206 chr6:149962617 T/C cg07701084 chr6:150067640 NUP43 0.42 5.82 0.34 1.7e-8 Lung cancer; CESC trans rs765547 1.000 rs920588 chr8:19854267 C/T cg12649343 chr22:47023005 GRAMD4 -0.3 -6.21 -0.36 2.08e-9 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs7662987 0.517 rs1311615 chr4:100012261 G/A cg12011299 chr4:100065546 ADH4 0.59 6.45 0.37 5.25e-10 Smoking initiation; CESC cis rs2479724 0.905 rs2251274 chr6:41839438 T/G cg17623882 chr6:41773611 USP49 -0.42 -6.19 -0.36 2.29e-9 Menarche (age at onset); CESC cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg23583168 chr7:148888333 NA -0.77 -11.19 -0.57 4.52e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7520050 0.966 rs10890363 chr1:46356148 C/T cg24296786 chr1:45957014 TESK2 -0.43 -5.34 -0.31 2e-7 Red blood cell count;Reticulocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14666069 chr1:155145896 TRIM46;KRTCAP2 0.56 6.12 0.35 3.34e-9 Gut microbiome composition (summer); CESC cis rs10979 1.000 rs9484768 chr6:143887928 C/T cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.11e-17 Hypospadias; CESC cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg07701084 chr6:150067640 NUP43 -0.44 -5.97 -0.34 7.79e-9 Lung cancer; CESC cis rs9910055 0.540 rs609292 chr17:42180436 G/A cg19774624 chr17:42201019 HDAC5 0.62 8.84 0.48 1.33e-16 Total body bone mineral density; CESC cis rs938554 0.571 rs12509955 chr4:10024303 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -6.89 -0.39 4.17e-11 Blood metabolite levels; CESC cis rs1559088 0.847 rs3760891 chr19:33599708 C/T cg27124370 chr19:33622961 WDR88 0.45 5.86 0.34 1.34e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg05313129 chr8:58192883 C8orf71 -0.54 -6.28 -0.36 1.4e-9 Developmental language disorder (linguistic errors); CESC cis rs2180341 1.000 rs6910763 chr6:127630925 T/C cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6e-39 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19199483 chr13:111483035 NA 0.45 6.48 0.37 4.37e-10 Fibrinogen levels; CESC cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg06713675 chr4:122721982 EXOSC9 -0.51 -6.96 -0.39 2.71e-11 Type 2 diabetes; CESC cis rs2108622 0.683 rs112571591 chr19:15977445 G/A cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs10504229 0.500 rs9772760 chr8:57986999 G/C cg24829409 chr8:58192753 C8orf71 -0.36 -5.08 -0.3 7.21e-7 Developmental language disorder (linguistic errors); CESC cis rs8114671 0.836 rs6120778 chr20:33565169 T/C cg06115741 chr20:33292138 TP53INP2 0.46 5.45 0.32 1.14e-7 Height; CESC cis rs6582630 0.555 rs1829583 chr12:38423161 T/C cg26384229 chr12:38710491 ALG10B -0.63 -9.48 -0.5 1.55e-18 Drug-induced liver injury (flucloxacillin); CESC cis rs10949834 1.000 rs8326 chr7:73483689 G/C cg07137043 chr7:73588983 EIF4H -0.65 -5.99 -0.35 6.97e-9 Verbal memory performance (residualized delayed recall change); CESC cis rs7818688 0.929 rs73276439 chr8:96035892 C/A cg16049864 chr8:95962084 TP53INP1 0.6 5.76 0.33 2.27e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs35110281 0.517 rs11089020 chr21:44939991 C/T cg04455712 chr21:45112962 RRP1B 0.34 5.09 0.3 6.86e-7 Mean corpuscular volume; CESC trans rs61931739 0.658 rs4476006 chr12:34237154 A/C cg26384229 chr12:38710491 ALG10B 0.49 6.73 0.38 1.02e-10 Morning vs. evening chronotype; CESC cis rs3733585 0.699 rs7437120 chr4:9967683 T/A cg11266682 chr4:10021025 SLC2A9 -0.58 -10.89 -0.56 4.5e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs72829446 0.530 rs7210292 chr17:7380305 G/T cg02795151 chr17:7402630 POLR2A 0.55 5.82 0.34 1.72e-8 Androgen levels; CESC cis rs11792861 0.888 rs75543406 chr9:111816903 A/T cg13535736 chr9:111863775 C9orf5 -0.52 -6.91 -0.39 3.63e-11 Menarche (age at onset); CESC cis rs34779708 0.733 rs7070778 chr10:35541688 T/C cg03585969 chr10:35415529 CREM 0.56 6.42 0.37 6.15e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg08928321 chr10:70748447 KIAA1279 -0.44 -6.27 -0.36 1.42e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24148044 chr16:85061578 KIAA0513 0.61 7.21 0.4 5.95e-12 Gut microbiome composition (summer); CESC cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg17211192 chr8:82754475 SNX16 -0.6 -7.75 -0.43 1.92e-13 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09546895 chr5:32174322 GOLPH3 0.57 7.04 0.4 1.65e-11 Gut microbiome composition (summer); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg01632260 chr4:89183583 PPM1K 0.4 6.01 0.35 6.2e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15487600 chr1:155113158 DPM3 -0.49 -6.17 -0.35 2.56e-9 Ulcerative colitis; CESC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.82 -9.22 -0.49 9.78e-18 Gut microbiome composition (summer); CESC cis rs17253792 0.545 rs12893610 chr14:56016347 C/T cg01858014 chr14:56050164 KTN1 -0.86 -6.4 -0.37 7.2e-10 Putamen volume; CESC cis rs1538970 0.748 rs11211137 chr1:46013892 T/A cg05343316 chr1:45956843 TESK2 0.91 11.59 0.58 2.07e-25 Platelet count; CESC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 9.38 0.5 3.07e-18 Platelet count; CESC cis rs4919087 1.000 rs10882898 chr10:99087330 G/A cg25902810 chr10:99078978 FRAT1 -0.66 -8.61 -0.47 6.57e-16 Monocyte count; CESC cis rs4481887 0.927 rs12039929 chr1:248482018 G/A cg00666640 chr1:248458726 OR2T12 0.36 5.9 0.34 1.11e-8 Common traits (Other); CESC cis rs17666538 0.585 rs336437 chr8:636251 A/C cg02524346 chr8:600233 NA 0.85 6.42 0.37 6.23e-10 IgG glycosylation; CESC cis rs12497850 0.644 rs11928552 chr3:48739883 T/C cg07636037 chr3:49044803 WDR6 0.94 15.05 0.68 2.07e-37 Parkinson's disease; CESC cis rs6429082 0.668 rs291395 chr1:235652049 A/C cg26050004 chr1:235667680 B3GALNT2 -0.64 -9.62 -0.51 5.38e-19 Adiposity; CESC cis rs4930561 0.765 rs1894204 chr11:67929671 C/T cg16338278 chr11:67432957 ALDH3B2 0.41 5.18 0.3 4.32e-7 Breast cancer in childhood cancer survivors;IgG glycosylation; CESC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg23221052 chr5:179740743 GFPT2 -0.55 -7.36 -0.41 2.32e-12 Height; CESC cis rs6662572 1.000 rs7541935 chr1:46217493 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 5.62 0.33 4.83e-8 Blood protein levels; CESC cis rs7116495 0.609 rs2155142 chr11:71642524 A/G cg10381502 chr11:71823885 C11orf51 0.9 6.15 0.35 2.92e-9 Severe influenza A (H1N1) infection; CESC cis rs28489187 0.706 rs4949890 chr1:85830632 T/C cg16011679 chr1:85725395 C1orf52 0.57 6.38 0.36 7.83e-10 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08024316 chr17:73401273 GRB2 -0.49 -7.05 -0.4 1.59e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg02551604 chr5:131831745 NA -0.37 -5.22 -0.31 3.53e-7 Asthma (sex interaction); CESC cis rs4919687 0.550 rs12775883 chr10:104485301 G/A cg04362960 chr10:104952993 NT5C2 0.48 5.45 0.32 1.18e-7 Colorectal cancer; CESC cis rs1559088 0.895 rs1974784 chr19:33551563 T/G cg17764715 chr19:33622953 WDR88 0.45 5.66 0.33 3.86e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs10489202 0.683 rs202260 chr1:167956167 G/T cg24449463 chr1:168025552 DCAF6 -0.45 -5.76 -0.33 2.36e-8 Schizophrenia; CESC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg23758822 chr17:41437982 NA 1.05 15.64 0.69 1.68e-39 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15230273 chr5:107006413 EFNA5 0.44 6.0 0.35 6.4e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9902453 0.817 rs4794861 chr17:28183174 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 8.19 0.45 1.09e-14 Coffee consumption (cups per day); CESC cis rs73206853 0.764 rs57033697 chr12:110550992 G/A cg12870014 chr12:110450643 ANKRD13A 0.65 5.63 0.33 4.52e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs12464559 0.522 rs4316939 chr2:152525120 C/T cg01189475 chr2:152685088 ARL5A -0.56 -5.2 -0.3 3.98e-7 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs6032067 0.641 rs13042991 chr20:43767178 A/G cg10761708 chr20:43804764 PI3 0.54 6.11 0.35 3.62e-9 Blood protein levels; CESC cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg05347473 chr6:146136440 FBXO30 -0.58 -6.9 -0.39 3.9e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1348850 0.668 rs4893972 chr2:178496874 T/C cg22681709 chr2:178499509 PDE11A -0.41 -5.9 -0.34 1.09e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6982240 0.514 rs10088801 chr8:142275801 T/C cg00131261 chr8:142287264 NA -0.54 -7.43 -0.42 1.5e-12 Tonsillectomy; CESC trans rs9329221 0.510 rs4841282 chr8:9975604 C/A cg15556689 chr8:8085844 FLJ10661 0.5 6.29 0.36 1.3e-9 Neuroticism; CESC cis rs7592578 0.771 rs75579212 chr2:191376575 C/T cg27211696 chr2:191398769 TMEM194B -0.62 -5.63 -0.33 4.7e-8 Diastolic blood pressure; CESC cis rs4460629 0.742 rs7366355 chr1:155076734 C/T cg01019262 chr1:155095195 NA -0.3 -5.06 -0.3 7.71e-7 Serum magnesium levels; CESC cis rs3820928 0.900 rs6754155 chr2:227784961 A/G cg11843606 chr2:227700838 RHBDD1 -0.49 -6.59 -0.38 2.33e-10 Pulmonary function; CESC cis rs7212590 0.748 rs7213697 chr17:57903041 G/C cg20303301 chr17:57937339 TUBD1 -0.59 -5.57 -0.32 6.14e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs2276314 0.762 rs3826600 chr18:33609053 A/G cg19628046 chr18:33552617 C18orf21 0.51 5.76 0.33 2.3e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs854765 0.583 rs62064156 chr17:17822480 C/T cg09796270 chr17:17721594 SREBF1 0.46 6.39 0.37 7.35e-10 Total body bone mineral density; CESC cis rs10191773 0.584 rs72831633 chr2:112945932 T/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.71 -6.95 -0.39 2.88e-11 Yeast infection; CESC cis rs7084402 0.967 rs1649041 chr10:60328782 T/C cg07615347 chr10:60278583 BICC1 0.59 9.18 0.49 1.26e-17 Refractive error; CESC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.37 -0.31 1.76e-7 Life satisfaction; CESC cis rs2243480 0.803 rs36127118 chr7:65565505 A/G cg18252515 chr7:66147081 NA -1.32 -12.9 -0.62 6.93e-30 Diabetic kidney disease; CESC cis rs1865760 0.566 rs9348706 chr6:26065481 G/C cg17691542 chr6:26056736 HIST1H1C 0.42 5.76 0.33 2.36e-8 Height; CESC cis rs9309473 0.539 rs7574268 chr2:73904872 C/T cg20560298 chr2:73613845 ALMS1 0.52 7.19 0.4 6.46e-12 Metabolite levels; CESC cis rs11122272 0.735 rs2808595 chr1:231526238 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.59 -0.42 5.44e-13 Hemoglobin concentration; CESC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg18402987 chr7:1209562 NA 0.75 7.52 0.42 8.71e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.26e-11 Skin colour saturation; CESC cis rs2415984 0.622 rs61993303 chr14:46949716 G/C cg14871534 chr14:47121158 RPL10L -0.38 -5.67 -0.33 3.72e-8 Number of children ever born; CESC cis rs9611519 1.000 rs2057070 chr22:41564287 T/C cg03806693 chr22:41940476 POLR3H -0.56 -5.74 -0.33 2.63e-8 Neuroticism; CESC cis rs11997175 0.574 rs12156280 chr8:33650277 C/T ch.8.33884649F chr8:33765107 NA 0.65 8.33 0.46 4.44e-15 Body mass index; CESC cis rs36051895 0.659 rs7046077 chr9:5045328 C/G cg02405213 chr9:5042618 JAK2 -0.43 -5.34 -0.31 2.01e-7 Pediatric autoimmune diseases; CESC cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs3760982 0.585 rs62116964 chr19:44291986 T/C cg11993925 chr19:44307056 LYPD5 0.33 5.68 0.33 3.62e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs714031 0.934 rs5757764 chr22:40067818 C/T cg21377881 chr22:40064566 CACNA1I -0.33 -5.3 -0.31 2.48e-7 Schizophrenia; CESC cis rs2197308 0.643 rs1842597 chr12:37862142 C/G cg26384229 chr12:38710491 ALG10B -0.53 -7.57 -0.42 6.06e-13 Morning vs. evening chronotype; CESC cis rs7552404 0.696 rs10518521 chr1:76461214 G/A cg22875332 chr1:76189707 ACADM 0.57 5.27 0.31 2.87e-7 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7937682 0.575 rs34888817 chr11:111756455 C/T cg09085632 chr11:111637200 PPP2R1B 0.92 12.04 0.59 6.56e-27 Primary sclerosing cholangitis; CESC cis rs7208859 0.510 rs216402 chr17:28917126 A/T cg13385521 chr17:29058706 SUZ12P 0.75 5.46 0.32 1.09e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs10435719 0.902 rs7459983 chr8:11807221 T/C cg15556689 chr8:8085844 FLJ10661 0.52 6.46 0.37 4.92e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs3820068 0.581 rs58425551 chr1:15922518 A/G cg13390004 chr1:15929781 NA 0.34 5.3 0.31 2.41e-7 Systolic blood pressure; CESC cis rs3733585 0.699 rs4588456 chr4:9963895 A/T cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs12477438 1.000 rs12053372 chr2:99810055 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.69 -8.4 -0.46 2.74e-15 Chronic sinus infection; CESC cis rs9611565 0.649 rs5751108 chr22:41858035 T/C cg06481639 chr22:41940642 POLR3H 0.64 6.5 0.37 3.86e-10 Vitiligo; CESC cis rs6061231 0.631 rs2427318 chr20:60975727 G/T cg06197360 chr20:60970103 CABLES2 -0.4 -5.72 -0.33 2.89e-8 Colorectal cancer; CESC cis rs858239 0.539 rs6945510 chr7:23192240 C/T cg23682824 chr7:23144976 KLHL7 0.51 6.79 0.38 7.41e-11 Cerebrospinal fluid biomarker levels; CESC cis rs5769707 0.967 rs9616701 chr22:50025546 G/A cg20744362 chr22:50050164 C22orf34 0.47 8.14 0.45 1.59e-14 Monocyte count;Monocyte percentage of white cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22478328 chr22:32340140 C22orf24;YWHAH -0.42 -6.06 -0.35 4.56e-9 Gambling; CESC cis rs7520050 0.966 rs4376778 chr1:46288846 C/G cg03146154 chr1:46216737 IPP -0.48 -6.3 -0.36 1.25e-9 Red blood cell count;Reticulocyte count; CESC cis rs11690935 0.655 rs1028127 chr2:172530036 T/C cg13550731 chr2:172543902 DYNC1I2 0.57 7.98 0.44 4.34e-14 Schizophrenia; CESC cis rs10979 0.965 rs9496674 chr6:143886106 G/T cg25407410 chr6:143891975 LOC285740 -0.62 -9.52 -0.51 1.1e-18 Hypospadias; CESC cis rs4704187 0.640 rs7721018 chr5:74492978 C/T cg03227963 chr5:74354835 NA 0.28 5.1 0.3 6.6e-7 Response to amphetamines; CESC cis rs4822044 0.680 rs8138780 chr22:42097462 A/T cg06634786 chr22:41940651 POLR3H 0.65 6.47 0.37 4.73e-10 Cannabis dependence symptom count; CESC cis rs1129187 0.837 rs4714634 chr6:42901120 G/A cg10862848 chr6:42927986 GNMT -0.24 -5.64 -0.33 4.32e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2456568 0.775 rs1607404 chr11:93660449 C/G cg26875233 chr11:93583750 C11orf90 -0.29 -5.09 -0.3 6.65e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs34779708 0.766 rs16935949 chr10:35551815 T/C cg03585969 chr10:35415529 CREM 0.55 6.19 0.36 2.25e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs6460942 0.597 rs17448913 chr7:12533984 T/C cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg18904891 chr8:8559673 CLDN23 0.69 8.06 0.44 2.63e-14 Obesity-related traits; CESC cis rs1784581 0.894 rs1626020 chr6:162383379 G/A cg17173639 chr6:162384350 PARK2 -0.83 -13.83 -0.65 4.07e-33 Itch intensity from mosquito bite; CESC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg27170947 chr2:26402098 FAM59B -0.58 -6.91 -0.39 3.63e-11 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13248847 chr17:7137857 DVL2 -0.46 -6.19 -0.36 2.3e-9 Ulcerative colitis; CESC cis rs2836633 0.929 rs4514962 chr21:40041753 C/T cg05519781 chr21:40033154 ERG 0.79 13.54 0.64 4.34e-32 Coronary artery disease; CESC cis rs2243480 1.000 rs160639 chr7:65579987 C/G cg12463550 chr7:65579703 CRCP 0.75 5.89 0.34 1.19e-8 Diabetic kidney disease; CESC cis rs7829975 0.714 rs4840362 chr8:8670082 C/G cg06636001 chr8:8085503 FLJ10661 -0.41 -5.46 -0.32 1.08e-7 Mood instability; CESC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg11764359 chr7:65958608 NA -0.73 -9.87 -0.52 8.76e-20 Aortic root size; CESC cis rs4629180 0.586 rs7583526 chr2:102124665 G/A cg04415270 chr2:102091202 RFX8 -0.31 -5.39 -0.31 1.57e-7 Chronic rhinosinusitis with nasal polyps; CESC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg01287605 chr22:46663522 TTC38 0.54 5.11 0.3 6.28e-7 LDL cholesterol;Cholesterol, total; CESC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.63 -0.51 5.27e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs3892630 0.878 rs2903759 chr19:33195947 A/G cg22980127 chr19:33182716 NUDT19 1.01 11.5 0.58 4.33e-25 Red blood cell traits; CESC cis rs6570726 0.526 rs4896805 chr6:145735429 C/A cg23711669 chr6:146136114 FBXO30 -0.54 -7.01 -0.4 2e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11799704 chr12:117187868 RNFT2 -0.44 -6.65 -0.38 1.68e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15023313 chr10:37414759 ANKRD30A 0.45 7.45 0.42 1.36e-12 Fibrinogen levels; CESC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg15445000 chr17:37608096 MED1 -0.41 -6.74 -0.38 9.82e-11 Glomerular filtration rate (creatinine); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03822003 chr16:30569878 ZNF764 -0.44 -6.3 -0.36 1.22e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs959260 0.925 rs1108355 chr17:73383913 A/T cg12999837 chr17:73267436 MIF4GD -0.52 -5.94 -0.34 8.69e-9 Systemic lupus erythematosus; CESC cis rs55871839 0.708 rs10098750 chr8:59813205 T/G cg07426533 chr8:59803705 TOX -0.47 -7.01 -0.4 1.95e-11 Pneumonia; CESC cis rs8067354 0.540 rs12600680 chr17:58037374 T/C cg13753209 chr17:57696993 CLTC 0.54 5.66 0.33 3.83e-8 Hemoglobin concentration; CESC cis rs6922893 0.961 rs2504735 chr6:71623655 C/G cg10766373 chr6:71666121 B3GAT2 0.33 5.15 0.3 5.17e-7 Obesity-related traits; CESC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg27170947 chr2:26402098 FAM59B 0.87 10.16 0.53 1.05e-20 Gut microbiome composition (summer); CESC cis rs478304 0.651 rs10896038 chr11:65505528 G/C cg10518572 chr11:65560635 OVOL1 -0.32 -6.19 -0.36 2.31e-9 Acne (severe); CESC cis rs12476592 0.571 rs6546005 chr2:63672071 G/A cg17519650 chr2:63277830 OTX1 -0.47 -5.28 -0.31 2.75e-7 Childhood ear infection; CESC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg09177884 chr7:1199841 ZFAND2A -0.49 -6.21 -0.36 2.04e-9 Longevity;Endometriosis; CESC cis rs1468333 0.538 rs13182414 chr5:137639838 T/G cg24847829 chr5:136834464 SPOCK1 0.27 5.05 0.3 8.37e-7 Resting heart rate; CESC cis rs2267137 0.903 rs5752903 chr22:29769306 G/T cg07256473 chr22:29710276 RASL10A 0.39 5.79 0.33 2.02e-8 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs34779708 0.966 rs12769575 chr10:35435927 A/T cg04310649 chr10:35416472 CREM -0.51 -6.21 -0.36 2.08e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs9818941 0.740 rs11713363 chr3:157828322 A/G cg08654915 chr3:157813417 NA 0.43 7.08 0.4 1.31e-11 Height; CESC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs9303401 1.000 rs6503882 chr17:56915761 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.72 9.41 0.5 2.58e-18 Cognitive test performance; CESC cis rs2635047 0.901 rs2684837 chr18:44749884 A/C cg19077165 chr18:44547161 KATNAL2 -0.4 -5.36 -0.31 1.82e-7 Educational attainment; CESC cis rs476633 0.708 rs28629856 chr15:41446950 C/T cg18705301 chr15:41695430 NDUFAF1 -0.61 -8.87 -0.48 1.08e-16 Glomerular filtration rate (creatinine); CESC cis rs8064299 0.584 rs2384957 chr17:72784630 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.82 13.93 0.65 1.87e-33 Monocyte count; CESC cis rs1152591 0.562 rs872227 chr14:64656165 T/C cg23250157 chr14:64679961 SYNE2 0.41 5.88 0.34 1.21e-8 Atrial fibrillation; CESC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg08859206 chr1:53392774 SCP2 -0.61 -8.04 -0.44 3e-14 Monocyte count; CESC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg18252515 chr7:66147081 NA 0.46 5.98 0.34 7.28e-9 Aortic root size; CESC cis rs61931739 0.500 rs7979482 chr12:34542877 C/A cg19457237 chr12:34500585 NA -0.37 -5.14 -0.3 5.27e-7 Morning vs. evening chronotype; CESC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg13012494 chr21:47604986 C21orf56 0.49 6.56 0.37 2.78e-10 Testicular germ cell tumor; CESC cis rs10129255 0.500 rs8021941 chr14:107189727 C/T cg23076370 chr14:107095027 NA -0.71 -11.07 -0.56 1.12e-23 Kawasaki disease; CESC cis rs28374715 0.635 rs8023530 chr15:41647775 T/C cg18705301 chr15:41695430 NDUFAF1 -0.78 -11.79 -0.59 4.63e-26 Ulcerative colitis; CESC cis rs7586673 0.866 rs747003 chr2:161916409 C/T cg22496339 chr2:162101262 NA -0.49 -6.52 -0.37 3.48e-10 Intelligence (multi-trait analysis); CESC cis rs7178909 0.902 rs8033554 chr15:90441569 C/A cg19708238 chr15:90437601 AP3S2 0.46 6.58 0.37 2.48e-10 Common traits (Other); CESC cis rs921968 0.565 rs4672897 chr2:219588134 A/G cg02176678 chr2:219576539 TTLL4 -0.43 -7.63 -0.42 4.22e-13 Mean corpuscular hemoglobin concentration; CESC cis rs6088590 1.000 rs1998028 chr20:33344595 A/T cg06115741 chr20:33292138 TP53INP2 0.59 7.29 0.41 3.51e-12 Coronary artery disease; CESC cis rs6060717 0.610 rs6058393 chr20:34608664 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -6.73 -0.38 1.07e-10 Hip circumference adjusted for BMI; CESC cis rs2014572 0.967 rs11084492 chr19:57756026 A/T cg24459738 chr19:57751996 ZNF805 -0.54 -7.78 -0.43 1.67e-13 Hyperactive-impulsive symptoms; CESC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg22823121 chr1:150693482 HORMAD1 0.47 6.98 0.39 2.34e-11 Tonsillectomy; CESC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.05e-8 Lung cancer; CESC cis rs4722166 0.630 rs1829927 chr7:22779918 G/A cg13104385 chr7:22767384 IL6 0.48 6.43 0.37 5.96e-10 Lung cancer; CESC cis rs2732480 0.577 rs2634678 chr12:48735538 C/G cg24011408 chr12:48396354 COL2A1 0.44 5.94 0.34 9.12e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg03209412 chr4:183728196 NA 0.55 5.28 0.31 2.63e-7 Pediatric autoimmune diseases; CESC cis rs11098499 0.954 rs4309825 chr4:120314881 C/T cg24375607 chr4:120327624 NA -0.4 -5.03 -0.3 9.03e-7 Corneal astigmatism; CESC trans rs1814175 0.654 rs7482446 chr11:49779020 A/G cg03929089 chr4:120376271 NA -0.9 -14.66 -0.67 4.99e-36 Height; CESC cis rs6121246 0.529 rs6060291 chr20:30198043 T/G cg13852791 chr20:30311386 BCL2L1 0.57 5.43 0.32 1.26e-7 Mean corpuscular hemoglobin; CESC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg12667521 chr19:29218732 NA 0.48 6.28 0.36 1.37e-9 Methadone dose in opioid dependence; CESC cis rs1801251 1.000 rs12987513 chr2:233622066 A/G cg08000102 chr2:233561755 GIGYF2 0.65 9.21 0.49 1.01e-17 Coronary artery disease; CESC cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.3e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7089973 0.604 rs10885618 chr10:116617718 A/G cg03647239 chr10:116582469 FAM160B1 0.47 6.05 0.35 4.79e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg11941060 chr3:133502564 NA -0.47 -6.5 -0.37 3.96e-10 Iron status biomarkers; CESC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.52 0.37 3.46e-10 Electroencephalogram traits; CESC cis rs9815354 0.951 rs55835726 chr3:41763049 C/T cg03022575 chr3:42003672 ULK4 0.51 5.1 0.3 6.62e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg23978390 chr7:1156363 C7orf50 0.45 6.05 0.35 5.04e-9 Longevity;Endometriosis; CESC cis rs3820068 0.705 rs4646031 chr1:15834648 A/G cg18192808 chr1:15853278 DNAJC16 0.46 5.65 0.33 4.16e-8 Systolic blood pressure; CESC trans rs2530545 0.851 rs2609231 chr7:34692376 G/C cg14080982 chr15:71736038 THSD4 -0.48 -6.27 -0.36 1.43e-9 IgG glycosylation; CESC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.15 0.4 8.48e-12 Height; CESC cis rs116095464 1.000 rs2015774 chr5:312958 G/T cg12570787 chr5:219185 SDHA;CCDC127 0.64 5.17 0.3 4.7e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17143303 chr17:33734764 NA -0.65 -6.78 -0.38 7.58e-11 Gut microbiome composition (summer); CESC cis rs863345 0.901 rs1117126 chr1:158509383 A/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.49 -0.37 4.3e-10 Pneumococcal bacteremia; CESC cis rs644148 0.785 rs2140111 chr19:44973019 A/C cg15540054 chr19:45004280 ZNF180 -0.6 -6.46 -0.37 4.86e-10 Personality dimensions; CESC cis rs300703 0.719 rs446488 chr2:195365 T/C cg21211680 chr2:198530 NA 1.07 12.54 0.61 1.25e-28 Blood protein levels; CESC cis rs4888262 0.526 rs8056718 chr16:74612030 G/C cg01733217 chr16:74700730 RFWD3 0.83 11.46 0.58 5.96e-25 Testicular germ cell tumor; CESC cis rs7809950 0.637 rs2701685 chr7:107299584 A/G cg23024343 chr7:107201750 COG5 0.39 5.31 0.31 2.27e-7 Coronary artery disease; CESC cis rs4948102 0.731 rs4689 chr7:56067016 G/T cg09872392 chr7:56161020 PHKG1 -0.44 -6.7 -0.38 1.23e-10 Plasma homocysteine levels (post-methionine load test); CESC cis rs2797160 0.967 rs8180614 chr6:126000599 G/C cg05901451 chr6:126070800 HEY2 -0.45 -6.67 -0.38 1.44e-10 Endometrial cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07312552 chr22:24819968 NA 0.54 6.28 0.36 1.39e-9 Gut microbiome composition (summer); CESC cis rs6500395 1.000 rs12447645 chr16:48694440 A/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC trans rs1945213 0.694 rs10895985 chr11:55831595 T/C cg15704280 chr7:45808275 SEPT13 0.76 7.31 0.41 3.2e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs1843834 0.505 rs4674911 chr2:225345254 A/G cg22455342 chr2:225449267 CUL3 0.69 9.77 0.51 1.84e-19 IgE levels in asthmatics (D.p. specific); CESC cis rs8072100 0.840 rs12452796 chr17:45479733 G/T cg08085267 chr17:45401833 C17orf57 0.51 6.8 0.39 6.81e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.84 -0.55 6.85e-23 Alzheimer's disease; CESC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg10351095 chr21:47802916 PCNT -0.49 -6.85 -0.39 5.2e-11 Testicular germ cell tumor; CESC trans rs681383 0.826 rs669168 chr18:8328770 G/A cg27042584 chr16:51168485 NA -0.5 -6.11 -0.35 3.55e-9 Sitting height ratio; CESC cis rs6893300 0.524 rs12374446 chr5:179131143 A/G cg14593053 chr5:179126677 CANX 0.47 6.64 0.38 1.74e-10 Resting heart rate; CESC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 11.93 0.59 1.55e-26 Platelet count; CESC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg18904891 chr8:8559673 CLDN23 -0.55 -5.9 -0.34 1.08e-8 Obesity-related traits; CESC cis rs36051895 0.664 rs62543877 chr9:5093465 C/A cg02405213 chr9:5042618 JAK2 -0.54 -6.57 -0.37 2.58e-10 Pediatric autoimmune diseases; CESC cis rs2235649 0.798 rs9922462 chr16:1848011 C/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -5.3 -0.31 2.43e-7 Blood metabolite levels; CESC cis rs12681288 0.523 rs11137122 chr8:954702 A/G cg04851639 chr8:1020857 NA -0.32 -6.32 -0.36 1.1e-9 Schizophrenia; CESC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.4 -0.31 1.48e-7 Lung cancer; CESC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg21280719 chr6:42927975 GNMT 0.3 7.08 0.4 1.26e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs116095464 0.614 rs10061564 chr5:271329 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.52 5.42 0.32 1.31e-7 Breast cancer; CESC cis rs6694270 0.913 rs3935030 chr1:19116956 C/T cg19637330 chr1:19110922 NA -0.48 -6.12 -0.35 3.42e-9 Drug-induced liver injury (nitrofurantoin); CESC trans rs9929218 0.953 rs2902323 chr16:68736292 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -9.26 -0.49 7.21e-18 Colorectal cancer; CESC cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg21573476 chr21:45109991 RRP1B -0.37 -5.22 -0.31 3.65e-7 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11309891 chr11:73388802 RAB6A -0.59 -6.99 -0.39 2.17e-11 Gut microbiome composition (summer); CESC cis rs9905704 0.681 rs1860262 chr17:56580997 T/C cg12560992 chr17:57184187 TRIM37 -0.65 -5.99 -0.35 6.72e-9 Testicular germ cell tumor; CESC cis rs6714710 0.580 rs11690737 chr2:98461953 C/T cg26665480 chr2:98280029 ACTR1B 0.56 7.92 0.44 6.74e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs660498 0.507 rs17681969 chr10:27734691 A/G cg25705717 chr10:27608719 NA 0.47 5.88 0.34 1.23e-8 Asthma (childhood onset); CESC cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 13.0 0.62 3.18e-30 Personality dimensions; CESC cis rs7945705 0.967 rs2568090 chr11:8849495 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.37 5.66 0.33 4.01e-8 Hemoglobin concentration; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg02331450 chr3:33155354 CRTAP -0.47 -6.31 -0.36 1.14e-9 Ulcerative colitis; CESC cis rs3096299 0.606 rs2965946 chr16:89516612 T/C cg16743903 chr16:89593216 SPG7 -0.51 -6.21 -0.36 2.03e-9 Multiple myeloma (IgH translocation); CESC cis rs6866344 0.570 rs1079487 chr5:178136005 G/A cg03877680 chr5:178157825 ZNF354A 0.82 10.03 0.52 2.8e-20 Neutrophil percentage of white cells; CESC cis rs12887734 0.546 rs4900597 chr14:104266664 A/G cg01849466 chr14:104193079 ZFYVE21 0.45 5.7 0.33 3.13e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs7071206 0.891 rs10824559 chr10:79409222 A/G cg07817648 chr10:79422355 NA -0.86 -10.32 -0.54 3.28e-21 Bone mineral density; CESC cis rs709400 0.663 rs62007681 chr14:103884651 G/A cg12935359 chr14:103987150 CKB -0.56 -8.18 -0.45 1.21e-14 Body mass index; CESC cis rs412050 0.502 rs75034650 chr22:22177949 C/T cg17089214 chr22:22089827 YPEL1 0.67 5.26 0.31 2.9e-7 Attention deficit hyperactivity disorder; CESC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg17971929 chr21:40555470 PSMG1 1.07 16.31 0.71 7.07e-42 Cognitive function; CESC cis rs7772486 0.686 rs1011596 chr6:146076433 A/G cg23711669 chr6:146136114 FBXO30 0.88 13.09 0.63 1.56e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.861 rs11078913 chr17:37671714 G/T cg19468946 chr17:37922297 IKZF3 -0.4 -5.24 -0.31 3.31e-7 Glomerular filtration rate (creatinine); CESC cis rs6701037 0.512 rs2285216 chr1:175133012 C/T cg00321850 chr1:175162397 KIAA0040 0.44 6.32 0.36 1.11e-9 Alcohol dependence; CESC cis rs10208940 0.920 rs10164780 chr2:68766250 A/T cg12452813 chr2:68675892 NA 0.51 5.11 0.3 6.17e-7 Urate levels in lean individuals; CESC cis rs367615 0.642 rs439182 chr5:108952367 A/G cg17395555 chr5:108820864 NA -0.42 -5.66 -0.33 4e-8 Colorectal cancer (SNP x SNP interaction); CESC cis rs9611565 0.592 rs5996037 chr22:41965292 A/G cg06634786 chr22:41940651 POLR3H -0.62 -6.75 -0.38 9.16e-11 Vitiligo; CESC cis rs57502260 0.651 rs3781586 chr11:68199393 C/A cg20283391 chr11:68216788 NA -0.58 -5.35 -0.31 1.95e-7 Total body bone mineral density (age 45-60); CESC cis rs17780086 0.529 rs7406406 chr17:30220153 T/G cg13647721 chr17:30228624 UTP6 0.83 10.88 0.56 5.03e-23 Height; CESC cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg11752832 chr7:134001865 SLC35B4 0.54 7.0 0.4 2.04e-11 Mean platelet volume; CESC cis rs6088580 0.634 rs2378133 chr20:32919505 C/G cg08999081 chr20:33150536 PIGU -0.65 -11.29 -0.57 2.07e-24 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg06873352 chr17:61820015 STRADA 0.73 12.98 0.62 3.9e-30 Prudent dietary pattern; CESC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg23048001 chr7:2026167 MAD1L1 0.41 5.44 0.32 1.22e-7 Schizophrenia; CESC cis rs12477438 0.520 rs11689265 chr2:99799267 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.01 0.7 7.88e-41 Chronic sinus infection; CESC trans rs4843747 0.749 rs72818535 chr16:88074039 G/A cg26811252 chr16:29126840 RRN3P2 0.69 9.65 0.51 4.35e-19 Menopause (age at onset); CESC cis rs9911578 0.967 rs1267542 chr17:56654690 T/C cg12560992 chr17:57184187 TRIM37 -0.93 -15.46 -0.69 7.17e-39 Intelligence (multi-trait analysis); CESC cis rs10411936 0.692 rs3810196 chr19:16601154 T/C cg10248733 chr19:16607483 C19orf44;CALR3 0.53 6.52 0.37 3.6e-10 White blood cell count;Multiple sclerosis; CESC cis rs1808579 0.904 rs1652348 chr18:21147509 C/T cg14672496 chr18:21087552 C18orf8 0.4 5.58 0.32 5.91e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs11958404 0.932 rs72816572 chr5:157429818 T/C cg05962755 chr5:157440814 NA 0.62 6.53 0.37 3.41e-10 IgG glycosylation; CESC cis rs2276314 0.947 rs16967319 chr18:33573525 A/G cg05985134 chr18:33552581 C18orf21 0.64 7.22 0.41 5.46e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs13102973 0.897 rs10434068 chr4:135840331 A/G cg14419869 chr4:135874104 NA 0.34 5.38 0.31 1.6e-7 Subjective well-being; CESC cis rs4955124 0.558 rs12485595 chr3:32018354 C/T cg05935571 chr3:32023257 ZNF860;OSBPL10 0.98 8.8 0.48 1.77e-16 Schizophrenia; CESC cis rs7335046 0.536 rs7992229 chr13:100040979 G/A cg21788972 chr13:99853209 UBAC2 -0.43 -5.59 -0.32 5.66e-8 Basal cell carcinoma; CESC cis rs9796 0.674 rs6492978 chr15:41317702 T/C cg18705301 chr15:41695430 NDUFAF1 -0.41 -6.17 -0.35 2.5e-9 Menopause (age at onset); CESC cis rs2228479 0.850 rs11639788 chr16:89807543 G/A cg06558623 chr16:89946397 TCF25 1.14 9.11 0.49 2.11e-17 Skin colour saturation; CESC trans rs9325144 0.555 rs28738714 chr12:38706912 G/A cg23762105 chr12:34175262 ALG10 0.49 6.35 0.36 9.17e-10 Morning vs. evening chronotype; CESC cis rs4888262 0.526 rs7193423 chr16:74626340 A/C cg01733217 chr16:74700730 RFWD3 0.86 11.16 0.57 5.72e-24 Testicular germ cell tumor; CESC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg27165867 chr14:105738592 BRF1 -0.54 -6.1 -0.35 3.81e-9 Mean platelet volume;Platelet distribution width; CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg20151795 chr6:28129481 ZNF389 0.46 5.9 0.34 1.1e-8 Depression; CESC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg11301795 chr4:187892539 NA -0.75 -12.33 -0.6 6.74e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs113835537 0.529 rs2298806 chr11:66282095 G/A cg22134325 chr11:66188745 NPAS4 0.37 5.81 0.34 1.77e-8 Airway imaging phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06431905 chr5:148931119 CSNK1A1 0.67 8.55 0.46 9.88e-16 Gut microbiome composition (summer); CESC cis rs10492096 0.947 rs10849484 chr12:6637941 C/T cg13857086 chr12:6580257 VAMP1 0.56 5.44 0.32 1.18e-7 Hip geometry; CESC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg04414720 chr1:150670196 GOLPH3L 0.58 7.57 0.42 6.07e-13 Melanoma; CESC cis rs8060686 0.516 rs8062085 chr16:68289313 C/A cg26727032 chr16:67993705 SLC12A4 -0.56 -7.31 -0.41 3.15e-12 HDL cholesterol;Metabolic syndrome; CESC cis rs12600856 1 rs12600856 chr17:38163295 T/C cg17467752 chr17:38218738 THRA 0.69 10.55 0.54 5.78e-22 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC cis rs7474896 0.537 rs1022449 chr10:38279467 T/A cg25427524 chr10:38739819 LOC399744 0.49 5.42 0.32 1.35e-7 Obesity (extreme); CESC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg06713675 chr4:122721982 EXOSC9 -0.51 -6.99 -0.39 2.2e-11 Type 2 diabetes; CESC cis rs2290720 0.930 rs10778112 chr12:101713020 T/C cg22051763 chr12:101673672 UTP20 -0.47 -5.78 -0.33 2.09e-8 Brain structure (hippocampal volume); CESC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg22764044 chr5:178986830 RUFY1 -0.47 -7.24 -0.41 4.81e-12 Lung cancer; CESC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg03452623 chr4:187889614 NA -0.94 -18.76 -0.76 1.57e-50 Lobe attachment (rater-scored or self-reported); CESC cis rs7605827 0.930 rs1549017 chr2:15617017 T/C cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs4700695 0.719 rs27584 chr5:65445232 G/A cg21114390 chr5:65439923 SFRS12 -0.51 -6.22 -0.36 1.96e-9 Facial morphology (factor 19); CESC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg15857475 chr8:145742913 RECQL4;LRRC14 0.71 9.69 0.51 3.46e-19 Age at first birth; CESC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg18876405 chr7:65276391 NA 0.44 6.06 0.35 4.76e-9 Aortic root size; CESC cis rs4566357 1.000 rs6721237 chr2:227923357 T/A cg11843606 chr2:227700838 RHBDD1 -0.42 -5.28 -0.31 2.76e-7 Coronary artery disease; CESC cis rs4689388 0.926 rs4688987 chr4:6287329 C/T cg00701064 chr4:6280414 WFS1 0.73 12.84 0.62 1.11e-29 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2243480 1.000 rs313824 chr7:65581207 C/T cg12463550 chr7:65579703 CRCP 0.74 5.77 0.33 2.23e-8 Diabetic kidney disease; CESC cis rs7208859 0.573 rs8070182 chr17:29135594 A/C cg13385521 chr17:29058706 SUZ12P 0.76 6.26 0.36 1.53e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4547160 0.606 rs12828712 chr12:63475233 G/C cg26727693 chr12:63544175 AVPR1A -0.38 -5.42 -0.32 1.31e-7 Morning vs. evening chronotype; CESC cis rs1865721 0.656 rs724765 chr18:73139794 A/G cg26385618 chr18:73139727 C18orf62 -0.45 -7.25 -0.41 4.49e-12 Intelligence; CESC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg02427764 chr11:65769310 BANF1;EIF1AD -0.44 -5.12 -0.3 6.02e-7 Breast cancer; CESC cis rs11098499 0.618 rs28491261 chr4:120294900 C/A cg09307838 chr4:120376055 NA 0.92 12.42 0.61 3.18e-28 Corneal astigmatism; CESC trans rs9329221 0.537 rs6986911 chr8:9978523 C/T cg15556689 chr8:8085844 FLJ10661 0.49 6.14 0.35 3.03e-9 Neuroticism; CESC cis rs7208859 0.623 rs11650973 chr17:29214045 G/A cg19761014 chr17:28927070 LRRC37B2 0.63 5.31 0.31 2.38e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs17376456 0.877 rs12153501 chr5:93360866 T/G cg21475434 chr5:93447410 FAM172A 0.77 6.93 0.39 3.17e-11 Diabetic retinopathy; CESC cis rs8070624 0.543 rs7219320 chr17:17880877 A/G cg04398451 chr17:18023971 MYO15A -0.69 -9.6 -0.51 6.26e-19 Total body bone mineral density; CESC cis rs7274811 0.744 rs3746460 chr20:32248163 C/T cg21523528 chr20:32077966 CBFA2T2 0.56 6.28 0.36 1.36e-9 Height; CESC cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 11.7 0.58 9.02e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11792861 0.926 rs59904140 chr9:111910051 C/T cg13535736 chr9:111863775 C9orf5 -0.41 -5.3 -0.31 2.47e-7 Menarche (age at onset); CESC cis rs1983891 0.706 rs3800285 chr6:41558443 C/T cg20194872 chr6:41519635 FOXP4 -0.46 -6.67 -0.38 1.48e-10 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15985338 chr7:6048868 PMS2;AIMP2 0.58 6.8 0.39 6.73e-11 Gut microbiome composition (summer); CESC cis rs854765 0.663 rs3744115 chr17:17749822 G/A cg09796270 chr17:17721594 SREBF1 -0.46 -6.59 -0.38 2.37e-10 Total body bone mineral density; CESC cis rs2243480 1.000 rs316307 chr7:65570171 C/T cg13147721 chr7:65941812 NA -0.99 -9.31 -0.5 5.19e-18 Diabetic kidney disease; CESC cis rs7666738 0.606 rs28481322 chr4:99086638 T/C cg17366294 chr4:99064904 C4orf37 0.43 5.77 0.33 2.15e-8 Colonoscopy-negative controls vs population controls; CESC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg23978390 chr7:1156363 C7orf50 0.55 7.52 0.42 8.34e-13 Longevity;Endometriosis; CESC cis rs10751667 0.643 rs10751666 chr11:941933 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.44 -0.32 1.23e-7 Alzheimer's disease (late onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02235289 chr2:27852069 GPN1;CCDC121 -0.55 -6.48 -0.37 4.54e-10 Gut microbiome composition (summer); CESC cis rs6424115 0.743 rs2229580 chr1:24201109 C/T cg10978503 chr1:24200527 CNR2 0.33 6.64 0.38 1.73e-10 Immature fraction of reticulocytes; CESC trans rs4824093 0.610 rs73441787 chr22:50269646 A/G cg09872104 chr7:134855509 C7orf49 -0.97 -6.92 -0.39 3.45e-11 Amyotrophic lateral sclerosis (sporadic); CESC cis rs28374715 0.578 rs13313520 chr15:41629127 T/G cg18705301 chr15:41695430 NDUFAF1 -1.05 -15.76 -0.7 6.06e-40 Ulcerative colitis; CESC cis rs4253772 0.872 rs14843 chr22:46639462 A/T cg18190219 chr22:46762943 CELSR1 -0.61 -5.82 -0.34 1.66e-8 LDL cholesterol;Cholesterol, total; CESC cis rs13095912 1.000 rs4686666 chr3:185342847 T/C cg11274856 chr3:185301563 NA 0.34 5.49 0.32 9.19e-8 Systolic blood pressure; CESC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg24675658 chr1:53192096 ZYG11B 0.53 6.73 0.38 1.04e-10 Monocyte count; CESC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.36 -0.31 1.85e-7 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00097940 chr3:197476561 KIAA0226;FYTTD1 -0.44 -6.14 -0.35 3.05e-9 Gambling; CESC cis rs9399135 0.967 rs9373122 chr6:135373534 G/A cg22676075 chr6:135203613 NA 0.52 7.32 0.41 2.89e-12 Red blood cell count; CESC cis rs9611565 0.559 rs9611619 chr22:41986714 C/T cg03806693 chr22:41940476 POLR3H -1.16 -13.06 -0.63 1.99e-30 Vitiligo; CESC cis rs10159302 0.714 rs11809894 chr1:57796019 A/G cg23691223 chr1:57785036 DAB1 -0.45 -5.34 -0.31 2.03e-7 HIV-1 control; CESC cis rs6088590 0.930 rs6087618 chr20:33288407 C/T cg06115741 chr20:33292138 TP53INP2 0.6 7.45 0.42 1.29e-12 Coronary artery disease; CESC cis rs6964587 1.000 rs12531366 chr7:91683849 C/G cg17063962 chr7:91808500 NA 0.56 7.61 0.42 4.83e-13 Breast cancer; CESC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg10691866 chr7:65817282 TPST1 0.33 5.2 0.3 4.02e-7 Aortic root size; CESC cis rs3806843 0.706 rs1089305 chr5:140066306 T/C cg16179182 chr5:140090404 VTRNA1-1 0.39 5.11 0.3 6.21e-7 Depressive symptoms (multi-trait analysis); CESC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg00074818 chr8:8560427 CLDN23 0.34 5.03 0.3 9.11e-7 Obesity-related traits; CESC cis rs6831352 1.000 rs6837685 chr4:100049145 G/A cg21548116 chr4:100009993 ADH5 0.48 5.15 0.3 4.98e-7 Alcohol dependence; CESC cis rs763014 0.898 rs4984897 chr16:632180 G/C cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC trans rs2727020 0.823 rs7102374 chr11:49261795 G/A cg03929089 chr4:120376271 NA 0.75 9.66 0.51 4.18e-19 Coronary artery disease; CESC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg07747251 chr5:1868357 NA 0.33 5.59 0.32 5.71e-8 Cardiovascular disease risk factors; CESC cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg08736216 chr1:53307985 ZYG11A 0.3 5.05 0.3 8.16e-7 Monocyte count; CESC cis rs3126085 1.000 rs114304428 chr1:152254010 T/C cg03465714 chr1:152285911 FLG 0.49 5.43 0.32 1.24e-7 Atopic dermatitis; CESC cis rs911555 0.504 rs61995761 chr14:104075712 T/C cg24130564 chr14:104152367 KLC1 -0.82 -13.38 -0.63 1.58e-31 Intelligence (multi-trait analysis); CESC cis rs6032067 0.929 rs6017503 chr20:43815103 G/A cg11264863 chr20:43835661 SEMG1 0.49 5.32 0.31 2.21e-7 Blood protein levels; CESC cis rs911555 0.723 rs2273701 chr14:103923225 G/T cg24130564 chr14:104152367 KLC1 0.5 6.6 0.38 2.27e-10 Intelligence (multi-trait analysis); CESC cis rs4692589 0.772 rs34642369 chr4:170973469 G/A cg19918862 chr4:170955249 NA 0.39 5.26 0.31 2.92e-7 Anxiety disorder; CESC cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs17826219 0.706 rs609472 chr17:28951427 T/C cg19761014 chr17:28927070 LRRC37B2 0.81 7.5 0.42 9.82e-13 Body mass index; CESC cis rs763014 0.932 rs4984898 chr16:641164 G/T cg09263875 chr16:632152 PIGQ 0.68 11.14 0.56 6.77e-24 Height; CESC cis rs2243480 1.000 rs316325 chr7:65609518 G/A cg13147721 chr7:65941812 NA -0.97 -9.14 -0.49 1.7e-17 Diabetic kidney disease; CESC cis rs787274 0.718 rs4979173 chr9:115627699 A/C cg13803584 chr9:115635662 SNX30 -0.66 -6.1 -0.35 3.77e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6752107 1.000 rs34123137 chr2:234167881 T/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.46 6.33 0.36 1.03e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs2072499 0.750 rs55910626 chr1:156159909 C/G cg25208724 chr1:156163844 SLC25A44 1.0 12.82 0.62 1.34e-29 Testicular germ cell tumor; CESC cis rs2228479 0.850 rs9282681 chr16:89805914 T/C cg06558623 chr16:89946397 TCF25 1.07 8.36 0.46 3.66e-15 Skin colour saturation; CESC cis rs8114671 0.552 rs2024635 chr20:33422614 G/A cg08999081 chr20:33150536 PIGU 0.38 5.34 0.31 2.05e-7 Height; CESC cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg11812906 chr14:75593930 NEK9 -0.85 -13.68 -0.64 1.4e-32 Height; CESC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6815814 0.898 rs6848423 chr4:38887933 C/T cg02016764 chr4:38805732 TLR1 -0.56 -6.63 -0.38 1.85e-10 Breast cancer; CESC cis rs6088580 0.634 rs6059905 chr20:33126946 T/C cg08999081 chr20:33150536 PIGU 0.67 11.59 0.58 2.17e-25 Glomerular filtration rate (creatinine); CESC cis rs9790314 0.905 rs4856739 chr3:160986710 A/C cg03342759 chr3:160939853 NMD3 -0.48 -6.29 -0.36 1.28e-9 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs2576037 0.583 rs578451 chr18:44404525 T/A cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.3 0.31 2.43e-7 Personality dimensions; CESC cis rs9640161 0.750 rs11769348 chr7:150026753 C/T cg10018233 chr7:150070692 REPIN1 -0.42 -6.42 -0.37 6.22e-10 Blood protein levels;Circulating chemerin levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16823105 chr6:97372572 KLHL32 0.44 6.19 0.36 2.26e-9 Systemic lupus erythematosus; CESC trans rs561341 1.000 rs113676348 chr17:30244327 A/G cg27661571 chr11:113659931 NA -0.7 -7.09 -0.4 1.19e-11 Hip circumference adjusted for BMI; CESC cis rs116095464 0.558 rs6872854 chr5:209038 G/T cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.55 0.32 7.07e-8 Breast cancer; CESC cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg26597838 chr10:835615 NA -0.86 -9.09 -0.49 2.44e-17 Eosinophil percentage of granulocytes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16432235 chr1:41976593 HIVEP3 0.49 6.95 0.39 2.88e-11 Fibrinogen levels; CESC cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg24881330 chr22:46731750 TRMU 0.81 6.95 0.39 2.82e-11 LDL cholesterol;Cholesterol, total; CESC cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg11890956 chr21:40555474 PSMG1 0.83 9.01 0.48 4.34e-17 Cognitive function; CESC cis rs9611565 0.559 rs5758428 chr22:42106216 G/A cg06481639 chr22:41940642 POLR3H 0.6 6.04 0.35 5.18e-9 Vitiligo; CESC cis rs1801251 0.778 rs812383 chr2:233737132 C/A cg25237894 chr2:233734115 C2orf82 -0.5 -8.95 -0.48 6.53e-17 Coronary artery disease; CESC cis rs17376456 0.877 rs9314092 chr5:93326362 A/G cg25358565 chr5:93447407 FAM172A 1.06 10.35 0.54 2.67e-21 Diabetic retinopathy; CESC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.42 5.72 0.33 2.94e-8 Menopause (age at onset); CESC cis rs636291 0.517 rs2781233 chr1:10529194 T/C cg07384165 chr1:10488281 NA -0.58 -8.37 -0.46 3.38e-15 Prostate cancer; CESC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg11663144 chr21:46675770 NA -0.63 -9.75 -0.51 2.19e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs734999 0.545 rs10910111 chr1:2542653 A/G cg18854424 chr1:2615690 NA 0.3 6.09 0.35 3.96e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01518846 chr6:26246970 HIST1H4G -0.63 -6.78 -0.38 7.98e-11 Gut microbiome composition (summer); CESC cis rs7914558 0.966 rs1971589 chr10:104744406 A/G cg04362960 chr10:104952993 NT5C2 0.45 5.74 0.33 2.65e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg11764359 chr7:65958608 NA 0.78 11.31 0.57 1.86e-24 Aortic root size; CESC cis rs8072100 0.840 rs56952963 chr17:45493826 T/C cg08085267 chr17:45401833 C17orf57 -0.53 -7.22 -0.41 5.35e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg05234568 chr11:5960015 NA 0.65 9.92 0.52 6.21e-20 DNA methylation (variation); CESC cis rs244293 0.831 rs2111097 chr17:53090474 A/C cg19360675 chr17:53046073 COX11;STXBP4 0.4 5.06 0.3 7.99e-7 Menarche (age at onset); CESC cis rs911555 0.504 rs4444269 chr14:104072724 G/C cg24130564 chr14:104152367 KLC1 -0.78 -12.61 -0.61 7.33e-29 Intelligence (multi-trait analysis); CESC cis rs10504073 0.584 rs74457150 chr8:49890753 C/G cg00325661 chr8:49890786 NA 0.56 8.52 0.46 1.26e-15 Blood metabolite ratios; CESC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg26354017 chr1:205819088 PM20D1 0.7 10.99 0.56 2.19e-23 Monocyte percentage of white cells; CESC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg01416388 chr22:39784598 NA 0.5 5.98 0.35 7.03e-9 Intelligence (multi-trait analysis); CESC cis rs2948294 0.588 rs12544596 chr8:8116346 A/T cg06636001 chr8:8085503 FLJ10661 0.45 5.39 0.31 1.57e-7 Red cell distribution width; CESC cis rs6088580 0.634 rs1890000 chr20:32968312 G/T cg06115741 chr20:33292138 TP53INP2 -0.46 -5.93 -0.34 9.51e-9 Glomerular filtration rate (creatinine); CESC cis rs7306456 0.623 rs10902513 chr12:132693487 A/G cg19601865 chr12:132687172 GALNT9 0.32 5.03 0.3 9.19e-7 Anti-saccade response; CESC cis rs10754283 0.967 rs10801760 chr1:90113824 G/A cg21401794 chr1:90099060 LRRC8C 0.69 9.34 0.5 4.06e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7818345 0.967 rs12678336 chr8:19280552 C/A cg11303988 chr8:19266685 CSGALNACT1 0.34 6.11 0.35 3.47e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg00339695 chr16:24857497 SLC5A11 0.52 6.84 0.39 5.54e-11 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13620366 chr9:138839624 UBAC1 0.52 7.09 0.4 1.24e-11 Fibrinogen levels; CESC cis rs7216064 0.953 rs4790905 chr17:65863350 C/A cg07042672 chr17:66097459 LOC651250 -0.57 -6.57 -0.37 2.69e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6460942 0.915 rs7803051 chr7:12306904 A/T cg20607287 chr7:12443886 VWDE -0.49 -6.77 -0.38 8.08e-11 Coronary artery disease; CESC cis rs7786877 0.626 rs11770389 chr7:100221218 T/G cg20848291 chr7:100343083 ZAN -0.67 -6.94 -0.39 2.94e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6686643 1.000 rs6686643 chr1:165616588 T/C cg19407955 chr1:165599744 MGST3 -0.51 -5.3 -0.31 2.47e-7 Total ventricular volume; CESC cis rs7412746 0.634 rs4451553 chr1:150937329 C/T cg22823121 chr1:150693482 HORMAD1 0.42 5.81 0.34 1.77e-8 Melanoma; CESC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg18538332 chr22:24372958 LOC391322 -0.68 -9.7 -0.51 3.17e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs36051895 0.589 rs2224571 chr9:5196253 A/C cg02405213 chr9:5042618 JAK2 -0.52 -6.0 -0.35 6.34e-9 Pediatric autoimmune diseases; CESC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.52 5.41 0.32 1.44e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg23422044 chr7:1970798 MAD1L1 -0.49 -5.34 -0.31 1.95e-7 Bipolar disorder; CESC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.87 0.56 5.21e-23 Alzheimer's disease; CESC cis rs17376456 0.825 rs10079708 chr5:93261796 G/C cg21475434 chr5:93447410 FAM172A 0.74 6.16 0.35 2.67e-9 Diabetic retinopathy; CESC cis rs2251381 0.523 rs2832306 chr21:30754468 C/T cg24692254 chr21:30365293 RNF160 -0.39 -5.07 -0.3 7.63e-7 Selective IgA deficiency; CESC cis rs80130819 0.515 rs1793912 chr12:48387052 A/C cg05342945 chr12:48394962 COL2A1 -0.49 -5.97 -0.34 7.7e-9 Prostate cancer; CESC cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg03060546 chr3:49711283 APEH 0.45 5.62 0.33 4.84e-8 Parkinson's disease; CESC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.34 -0.36 9.61e-10 Total body bone mineral density; CESC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg09455208 chr3:40491958 NA 0.51 8.27 0.45 6.59e-15 Renal cell carcinoma; CESC cis rs60154123 0.730 rs12403947 chr1:210456524 A/G cg22029157 chr1:209979665 IRF6 -0.52 -6.1 -0.35 3.71e-9 Coronary artery disease; CESC cis rs10208940 0.920 rs7580719 chr2:68833572 A/G cg12452813 chr2:68675892 NA -0.53 -5.33 -0.31 2.08e-7 Urate levels in lean individuals; CESC cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg03467027 chr4:99064603 C4orf37 0.46 5.83 0.34 1.62e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2820292 0.740 rs12137232 chr1:201885446 G/T cg11586189 chr1:201857591 SHISA4 -0.34 -5.54 -0.32 7.21e-8 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23085882 chr19:893253 MED16 -0.6 -6.83 -0.39 5.92e-11 Gut microbiome composition (summer); CESC cis rs72901758 0.810 rs61740716 chr17:76244648 G/A cg26068271 chr17:76253126 NA 0.49 7.25 0.41 4.52e-12 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs2749592 0.588 rs2505192 chr10:38395023 G/A cg00409905 chr10:38381863 ZNF37A -0.54 -6.97 -0.39 2.46e-11 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg21214613 chr1:16344536 HSPB7 0.37 5.34 0.31 2.03e-7 Dilated cardiomyopathy; CESC cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg11752832 chr7:134001865 SLC35B4 0.51 6.52 0.37 3.54e-10 Mean platelet volume; CESC cis rs7586879 0.662 rs2384059 chr2:25100338 C/T cg01884057 chr2:25150051 NA 0.37 7.09 0.4 1.21e-11 Body mass index; CESC cis rs832540 0.864 rs832576 chr5:56163255 C/A cg14703610 chr5:56206110 C5orf35 0.44 5.78 0.33 2.11e-8 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03079549 chr15:45879223 PLDN 0.48 6.27 0.36 1.46e-9 Gut microbiota (bacterial taxa); CESC cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg11663144 chr21:46675770 NA 0.52 7.02 0.4 1.87e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs3892630 0.824 rs7247264 chr19:33239846 T/G cg13157960 chr19:33183277 NUDT19 0.55 5.12 0.3 5.91e-7 Red blood cell traits; CESC cis rs7949030 0.653 rs2849030 chr11:62366986 G/A cg22862634 chr11:62369728 EML3;MTA2 -0.53 -7.43 -0.42 1.47e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg19163074 chr7:65112434 INTS4L2 -0.43 -5.34 -0.31 2e-7 Aortic root size; CESC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs67311347 1.000 rs11720360 chr3:40448397 G/A cg09455208 chr3:40491958 NA 0.5 8.27 0.45 6.47e-15 Renal cell carcinoma; CESC cis rs6963495 0.818 rs6956234 chr7:105149707 A/G cg19920283 chr7:105172520 RINT1 0.66 6.28 0.36 1.36e-9 Bipolar disorder (body mass index interaction); CESC cis rs17818399 0.962 rs2122715 chr2:46845849 A/G cg02822958 chr2:46747628 ATP6V1E2 0.45 5.59 0.32 5.57e-8 Height; CESC cis rs4919087 1.000 rs10786333 chr10:99090390 A/G cg25902810 chr10:99078978 FRAT1 -0.68 -8.96 -0.48 5.86e-17 Monocyte count; CESC cis rs637571 0.522 rs493899 chr11:65747952 A/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.73 10.63 0.55 3.17e-22 Eosinophil percentage of white cells; CESC cis rs9911578 1.000 rs2333332 chr17:56631054 A/G cg12560992 chr17:57184187 TRIM37 -0.93 -15.47 -0.69 6.42e-39 Intelligence (multi-trait analysis); CESC cis rs698833 0.548 rs8410 chr2:44546016 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.54 5.6 0.33 5.28e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs4862750 0.872 rs13101380 chr4:187894744 G/A cg10295955 chr4:187884368 NA -1.02 -20.11 -0.78 2.9e-55 Lobe attachment (rater-scored or self-reported); CESC cis rs4835473 0.932 rs1450233 chr4:144695863 T/A cg25736465 chr4:144833511 NA -0.33 -5.18 -0.3 4.39e-7 Immature fraction of reticulocytes; CESC cis rs3008870 0.755 rs2815355 chr1:67485034 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.61 7.91 0.44 7.21e-14 Lymphocyte percentage of white cells; CESC cis rs7296418 0.961 rs10848428 chr12:123572495 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.33 -5.18 -0.3 4.43e-7 Platelet count; CESC cis rs67478160 0.595 rs12889993 chr14:104274294 A/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.76 0.55 1.22e-22 Schizophrenia; CESC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC trans rs2727020 0.533 rs10839195 chr11:48973460 C/T cg15704280 chr7:45808275 SEPT13 -0.55 -6.65 -0.38 1.68e-10 Coronary artery disease; CESC cis rs10883723 0.810 rs1884929 chr10:104275418 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.58 0.42 5.73e-13 Allergic disease (asthma, hay fever or eczema); CESC trans rs2235573 0.527 rs139887 chr22:38371396 G/C cg19894588 chr14:64061835 NA 0.57 7.43 0.42 1.5e-12 Glioblastoma;Glioma; CESC cis rs9926296 0.533 rs12102290 chr16:89812617 C/T cg07648498 chr16:89883185 FANCA 0.49 6.21 0.36 1.99e-9 Vitiligo; CESC cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.23e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg18230493 chr5:56204884 C5orf35 -0.62 -8.31 -0.45 4.87e-15 Initial pursuit acceleration; CESC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg06481639 chr22:41940642 POLR3H -0.61 -6.39 -0.37 7.34e-10 Vitiligo; CESC cis rs757110 0.745 rs10734252 chr11:17404839 G/A cg15432903 chr11:17409602 KCNJ11 0.62 8.64 0.47 5.32e-16 Type 2 diabetes; CESC cis rs17376456 0.825 rs17314797 chr5:93234845 T/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.24 0.31 3.31e-7 Diabetic retinopathy; CESC trans rs61931739 0.534 rs4931775 chr12:34050729 G/A cg26384229 chr12:38710491 ALG10B 0.6 8.36 0.46 3.68e-15 Morning vs. evening chronotype; CESC cis rs9611565 0.765 rs202659 chr22:41811620 T/C cg06634786 chr22:41940651 POLR3H 0.71 7.47 0.42 1.16e-12 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15959319 chr5:32174494 GOLPH3 -0.45 -6.13 -0.35 3.12e-9 Fibrinogen levels; CESC cis rs11650494 0.710 rs2119935 chr17:47471334 T/C cg08112188 chr17:47440006 ZNF652 0.84 6.39 0.37 7.58e-10 Prostate cancer; CESC cis rs1562975 0.609 rs55707402 chr4:109418264 T/A cg16022748 chr4:109541635 LOC285456;RPL34 0.42 5.38 0.31 1.66e-7 Height; CESC cis rs2180341 1.000 rs9285460 chr6:127640190 A/G cg27446573 chr6:127587934 RNF146 1.09 16.38 0.71 3.79e-42 Breast cancer; CESC cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.72 -8.19 -0.45 1.08e-14 Alzheimer's disease; CESC cis rs238295 0.805 rs6053486 chr20:5530767 T/G cg24001556 chr20:5591874 RP5-1022P6.2 -0.44 -5.09 -0.3 6.66e-7 Occipital cortical area (total cortical area interaction); CESC cis rs765787 0.505 rs11630884 chr15:45532246 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -6.81 -0.39 6.47e-11 Uric acid levels; CESC cis rs10484885 0.878 rs17763820 chr6:90569634 A/G cg13799429 chr6:90582589 CASP8AP2 -0.77 -7.37 -0.41 2.17e-12 QRS interval (sulfonylurea treatment interaction); CESC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.55 0.42 7.15e-13 Bipolar disorder; CESC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg17427002 chr7:12443146 VWDE -0.58 -6.01 -0.35 6.16e-9 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03570498 chr10:131566727 NA 0.52 6.75 0.38 9.09e-11 Fibrinogen levels; CESC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg18252515 chr7:66147081 NA 0.45 5.88 0.34 1.22e-8 Aortic root size; CESC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg06577658 chr19:46296270 DMWD 0.43 5.27 0.31 2.76e-7 Coronary artery disease; CESC cis rs2070488 0.775 rs2186457 chr3:38553965 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.75 11.85 0.59 2.86e-26 Electrocardiographic conduction measures; CESC cis rs1045902 0.583 rs36106493 chr2:73442339 C/T cg01422370 chr2:73384389 NA 0.35 5.52 0.32 8.23e-8 Intelligence (multi-trait analysis); CESC cis rs9287719 0.935 rs10803723 chr2:10722877 C/T cg02196655 chr2:10830764 NOL10 -0.36 -5.57 -0.32 6.1e-8 Prostate cancer; CESC cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg12292205 chr6:26970375 C6orf41 -0.5 -5.67 -0.33 3.8e-8 Intelligence (multi-trait analysis); CESC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg26335602 chr6:28129616 ZNF389 0.53 6.85 0.39 5.12e-11 Depression; CESC cis rs7917772 0.503 rs2031601 chr10:104308064 T/G cg22532475 chr10:104410764 TRIM8 -0.33 -5.74 -0.33 2.65e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs790123 1.000 rs790116 chr3:122380923 G/C cg17380795 chr3:122379686 NA 0.34 5.14 0.3 5.37e-7 Response to angiotensin II receptor blocker therapy; CESC cis rs34779708 0.742 rs35912711 chr10:35312996 T/C cg03585969 chr10:35415529 CREM 0.75 9.74 0.51 2.4e-19 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04935666 chr14:105817407 PACS2 -0.51 -6.23 -0.36 1.81e-9 Gut microbiome composition (summer); CESC cis rs7824557 0.591 rs2736283 chr8:11225910 A/G cg21775007 chr8:11205619 TDH -0.52 -8.27 -0.45 6.57e-15 Retinal vascular caliber; CESC cis rs4654899 1.000 rs6683542 chr1:21369610 T/C cg05370193 chr1:21551575 ECE1 0.38 5.78 0.33 2.1e-8 Superior frontal gyrus grey matter volume; CESC cis rs4604732 0.631 rs7546720 chr1:247627229 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg11764359 chr7:65958608 NA -0.82 -12.43 -0.61 2.88e-28 Aortic root size; CESC cis rs6732160 0.932 rs13417029 chr2:73380423 T/G cg01422370 chr2:73384389 NA 0.51 8.77 0.47 2.15e-16 Intelligence (multi-trait analysis); CESC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg24675658 chr1:53192096 ZYG11B 0.64 8.96 0.48 5.99e-17 Monocyte count; CESC cis rs7621025 0.500 rs9845460 chr3:136587117 A/G cg15507776 chr3:136538369 TMEM22 0.77 9.63 0.51 5.14e-19 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs10463316 0.925 rs6877344 chr5:150742650 C/T cg03212797 chr5:150827313 SLC36A1 -0.43 -5.04 -0.3 8.73e-7 Metabolite levels (Pyroglutamine); CESC cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg03467027 chr4:99064603 C4orf37 0.45 5.67 0.33 3.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs155076 1.000 rs261431 chr13:21865738 A/G cg23743428 chr13:21893420 NA -0.38 -5.09 -0.3 6.83e-7 White matter hyperintensity burden; CESC cis rs7918232 0.830 rs9833 chr10:27400861 G/A cg14240646 chr10:27532245 ACBD5 -0.66 -6.3 -0.36 1.21e-9 Breast cancer; CESC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg11494091 chr17:61959527 GH2 0.74 12.74 0.62 2.54e-29 Prudent dietary pattern; CESC cis rs9388451 0.626 rs1739384 chr6:126099246 C/A cg05901451 chr6:126070800 HEY2 -0.57 -8.3 -0.45 5.26e-15 Brugada syndrome; CESC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg00166722 chr3:10149974 C3orf24 0.55 6.83 0.39 5.64e-11 Alzheimer's disease; CESC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg08632164 chr7:65971372 NA 0.31 5.1 0.3 6.37e-7 Aortic root size; CESC cis rs8062405 0.823 rs7202948 chr16:28558289 T/A cg08761264 chr16:28874980 SH2B1 -0.41 -5.03 -0.3 8.87e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg26314531 chr2:26401878 FAM59B 0.83 8.36 0.46 3.57e-15 Gut microbiome composition (summer); CESC trans rs123509 0.913 rs339661 chr3:42753904 G/A cg22035501 chr5:112073398 APC 0.58 6.28 0.36 1.35e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs7945705 0.935 rs2653567 chr11:8889630 T/C cg10637292 chr12:52960529 KRT74 0.35 6.11 0.35 3.56e-9 Hemoglobin concentration; CESC cis rs7267979 1.000 rs13038834 chr20:25441433 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.34 0.69 1.94e-38 Liver enzyme levels (alkaline phosphatase); CESC cis rs6088590 1.000 rs3787222 chr20:33333040 T/A cg24642439 chr20:33292090 TP53INP2 0.85 11.75 0.59 5.97e-26 Coronary artery disease; CESC cis rs7296418 0.961 rs61955196 chr12:123451018 G/C cg00376283 chr12:123451042 ABCB9 0.73 10.27 0.53 4.75e-21 Platelet count; CESC cis rs916888 0.697 rs199516 chr17:44856485 C/T cg15921436 chr17:44337874 NA -0.71 -8.05 -0.44 2.83e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07505695 chr15:65281854 SPG21 -0.56 -6.48 -0.37 4.48e-10 Gut microbiome composition (summer); CESC cis rs9325144 0.560 rs11183150 chr12:38674698 A/G cg26384229 chr12:38710491 ALG10B -0.6 -8.5 -0.46 1.44e-15 Morning vs. evening chronotype; CESC cis rs2425143 0.908 rs11697087 chr20:34427583 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -6.06 -0.35 4.71e-9 Blood protein levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02120071 chr2:114737129 NA 0.46 6.1 0.35 3.76e-9 Fibrinogen levels; CESC cis rs367943 0.665 rs4705560 chr5:112977073 T/G cg12552261 chr5:112820674 MCC 0.44 5.67 0.33 3.72e-8 Type 2 diabetes; CESC cis rs1005224 0.889 rs9323617 chr14:76158638 A/G cg25116370 chr14:76127843 TTLL5;C14orf1 -0.44 -6.15 -0.35 2.87e-9 Large artery stroke; CESC cis rs854765 0.547 rs2955359 chr17:17946730 T/C cg16928487 chr17:17741425 SREBF1 0.55 9.13 0.49 1.86e-17 Total body bone mineral density; CESC cis rs1865721 0.804 rs3826652 chr18:73142153 C/T cg26385618 chr18:73139727 C18orf62 0.47 7.87 0.44 8.87e-14 Intelligence; CESC cis rs17253792 0.822 rs17685053 chr14:56125771 T/A cg24579896 chr14:56047964 C14orf33;KTN1 0.72 5.82 0.34 1.69e-8 Putamen volume; CESC cis rs909002 0.830 rs1356803 chr1:32131163 C/G cg13919466 chr1:32135498 COL16A1 -0.5 -9.08 -0.49 2.49e-17 Intelligence (multi-trait analysis); CESC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 21.45 0.8 7.43e-60 Prudent dietary pattern; CESC cis rs59918340 1.000 rs59918340 chr8:142232256 A/G cg23750338 chr8:142222470 SLC45A4 0.43 6.7 0.38 1.26e-10 Immature fraction of reticulocytes; CESC cis rs7618915 0.501 rs55678971 chr3:52717229 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.52 7.57 0.42 6.19e-13 Bipolar disorder; CESC cis rs8002861 0.846 rs12428112 chr13:44475821 C/A cg19180546 chr13:44453867 C13orf31;CCDC122 -0.45 -5.79 -0.34 1.94e-8 Leprosy; CESC cis rs2236918 0.965 rs2488472 chr1:242019919 T/C cg17736920 chr1:242011382 EXO1 0.73 9.67 0.51 3.87e-19 Menopause (age at onset); CESC cis rs1670533 1.000 rs6822863 chr4:1055606 G/A cg04106633 chr4:1044584 NA 0.4 5.12 0.3 6.01e-7 Recombination rate (females); CESC cis rs3768617 0.510 rs10797839 chr1:183077797 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.21 0.66 1.9e-34 Fuchs's corneal dystrophy; CESC cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg03467027 chr4:99064603 C4orf37 0.42 5.32 0.31 2.25e-7 Colonoscopy-negative controls vs population controls; CESC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg06505273 chr16:24850292 NA 0.51 5.87 0.34 1.27e-8 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01956158 chr8:132916947 EFR3A -0.44 -6.23 -0.36 1.86e-9 Gambling; CESC cis rs1707322 0.721 rs10789470 chr1:46158331 T/G cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1707322 0.717 rs12023439 chr1:46104636 C/T cg06784218 chr1:46089804 CCDC17 0.4 6.99 0.39 2.23e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2109514 0.840 rs2402080 chr7:116135016 G/C cg12739419 chr7:116140593 CAV2 -0.38 -6.74 -0.38 1.01e-10 Prevalent atrial fibrillation; CESC cis rs4660261 0.545 rs803682 chr1:44362623 G/A cg12908607 chr1:44402522 ARTN -0.49 -7.49 -0.42 1.04e-12 Intelligence (multi-trait analysis); CESC cis rs9287719 0.967 rs10203664 chr2:10752377 T/C cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg17789542 chr5:71604139 MRPS27 -0.49 -6.33 -0.36 1.04e-9 Asthma; CESC cis rs72634258 0.945 rs12727642 chr1:8046672 C/A cg00042356 chr1:8021962 PARK7 0.79 6.93 0.39 3.15e-11 Inflammatory bowel disease; CESC cis rs2295359 0.963 rs12030867 chr1:67627620 T/C cg03340356 chr1:67600835 NA 0.33 5.34 0.31 1.96e-7 Psoriasis; CESC cis rs56104184 0.775 rs55756106 chr19:49403055 A/G cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg23275840 chr4:47708675 CORIN -0.34 -6.41 -0.37 6.81e-10 Thyroid stimulating hormone; CESC trans rs853679 0.545 rs35949109 chr6:28025926 T/C cg06606381 chr12:133084897 FBRSL1 -0.76 -6.59 -0.38 2.31e-10 Depression; CESC cis rs9929218 0.551 rs3785133 chr16:68728611 C/T cg01251360 chr16:68772225 CDH1 -0.23 -5.24 -0.31 3.23e-7 Colorectal cancer; CESC cis rs4604732 0.588 rs7549955 chr1:247628321 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 6.01 0.35 6.07e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs897080 0.552 rs698793 chr2:44685685 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.33 0.31 2.09e-7 Height; CESC cis rs7772486 0.875 rs6914813 chr6:146397798 A/G cg23711669 chr6:146136114 FBXO30 0.86 12.76 0.62 2.12e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs7107174 1.000 rs2512550 chr11:77943848 C/T cg02023728 chr11:77925099 USP35 0.39 5.54 0.32 7.31e-8 Testicular germ cell tumor; CESC cis rs2070488 0.804 rs1817364 chr3:38474513 T/G cg24069376 chr3:38537580 EXOG 0.35 5.92 0.34 9.72e-9 Electrocardiographic conduction measures; CESC cis rs11264213 0.786 rs72659676 chr1:36254032 C/T cg27506609 chr1:36549197 TEKT2 0.61 5.04 0.3 8.54e-7 Schizophrenia; CESC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg12516959 chr21:47718080 NA 0.41 5.98 0.34 7.14e-9 Testicular germ cell tumor; CESC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg12463550 chr7:65579703 CRCP -0.48 -6.14 -0.35 2.99e-9 Aortic root size; CESC cis rs2290720 1.000 rs7312071 chr12:101698982 A/G cg22051763 chr12:101673672 UTP20 -0.42 -5.08 -0.3 7.02e-7 Brain structure (hippocampal volume); CESC cis rs5760092 0.618 rs4461358 chr22:24260106 T/C cg23131131 chr22:24373011 LOC391322 0.62 7.5 0.42 9.49e-13 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs367615 0.537 rs17161729 chr5:108660528 C/G cg17395555 chr5:108820864 NA -0.5 -8.07 -0.44 2.49e-14 Colorectal cancer (SNP x SNP interaction); CESC cis rs8077577 0.945 rs11655731 chr17:18107525 G/T cg16794390 chr17:18148240 FLII 0.46 5.78 0.33 2.12e-8 Obesity-related traits; CESC cis rs763121 0.651 rs738249 chr22:39037979 T/C cg14440974 chr22:39074834 NA -0.39 -5.18 -0.3 4.49e-7 Menopause (age at onset); CESC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg24642844 chr7:1081250 C7orf50 -0.53 -6.86 -0.39 4.83e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg05518842 chr16:1823291 MRPS34;EME2 0.47 6.17 0.35 2.48e-9 Breast cancer;Type 2 diabetes; CESC cis rs6598955 0.543 rs12122527 chr1:26549748 C/T cg04990556 chr1:26633338 UBXN11 0.8 9.15 0.49 1.57e-17 Obesity-related traits; CESC cis rs2050392 0.858 rs306583 chr10:30710057 C/T cg25182066 chr10:30743637 MAP3K8 0.42 5.77 0.33 2.21e-8 Inflammatory bowel disease; CESC cis rs208520 1.000 rs72884025 chr6:66994185 T/C cg07460842 chr6:66804631 NA 0.88 9.99 0.52 3.87e-20 Exhaled nitric oxide output; CESC cis rs61931739 0.500 rs11836207 chr12:34315177 G/A cg06521331 chr12:34319734 NA -0.46 -6.18 -0.35 2.41e-9 Morning vs. evening chronotype; CESC cis rs4253772 0.515 rs8142080 chr22:46647429 G/T cg00784671 chr22:46762841 CELSR1 -0.56 -5.8 -0.34 1.84e-8 LDL cholesterol;Cholesterol, total; CESC cis rs13385 0.728 rs10055141 chr5:139616609 T/C cg26211634 chr5:139558579 C5orf32 0.48 5.24 0.31 3.28e-7 Atrial fibrillation; CESC cis rs3733585 0.781 rs57250714 chr4:9984529 C/T cg00071950 chr4:10020882 SLC2A9 0.69 11.21 0.57 4.08e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg25072359 chr17:41440525 NA -0.5 -7.33 -0.41 2.72e-12 Menopause (age at onset); CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg12758922 chr20:37101595 RALGAPB 0.45 6.0 0.35 6.61e-9 Bronchopulmonary dysplasia; CESC trans rs2347503 0.510 rs16879344 chr8:32262521 A/G cg00536910 chr8:1319507 NA -0.68 -6.3 -0.36 1.27e-9 Cognitive function; CESC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.57 6.99 0.39 2.29e-11 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14195823 chr19:39926698 RPS16 0.62 7.02 0.4 1.85e-11 Gut microbiome composition (summer); CESC cis rs6580649 0.943 rs1990029 chr12:48407987 C/T cg05342945 chr12:48394962 COL2A1 -0.55 -6.27 -0.36 1.46e-9 Lung cancer; CESC cis rs3820068 0.581 rs58567918 chr1:15925823 A/G cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs2066819 0.786 rs116934693 chr12:56696545 T/G cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs9916302 0.904 rs2338755 chr17:37419317 C/T cg00129232 chr17:37814104 STARD3 0.55 7.23 0.41 5.14e-12 Glomerular filtration rate (creatinine); CESC cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg15017067 chr4:17643749 FAM184B 0.34 5.05 0.3 8.24e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs72781680 0.898 rs55841168 chr2:24007926 T/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs7208859 0.673 rs216440 chr17:28928309 A/T cg19761014 chr17:28927070 LRRC37B2 0.73 7.27 0.41 3.98e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7680126 0.633 rs4697975 chr4:10209966 A/T cg11266682 chr4:10021025 SLC2A9 -0.4 -5.31 -0.31 2.32e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs4805272 0.512 rs12373558 chr19:29337692 A/G cg12756686 chr19:29218302 NA 0.41 5.39 0.31 1.58e-7 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg19468946 chr17:37922297 IKZF3 -0.39 -5.12 -0.3 5.78e-7 Glomerular filtration rate (creatinine); CESC cis rs12579753 0.917 rs11115029 chr12:82202219 C/G cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs9911578 1.000 rs2643119 chr17:56827760 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.21 0.3 3.88e-7 Intelligence (multi-trait analysis); CESC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg07936489 chr17:37558343 FBXL20 0.76 10.63 0.55 3.3e-22 Glomerular filtration rate (creatinine); CESC cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11353064 chr12:57472281 TMEM194A 0.57 6.66 0.38 1.55e-10 Gut microbiome composition (summer); CESC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.3 0.31 2.47e-7 Cognitive function; CESC cis rs10911232 0.507 rs5022057 chr1:182997761 T/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC cis rs9388451 0.531 rs9321057 chr6:126156943 G/A cg05901451 chr6:126070800 HEY2 -0.44 -5.97 -0.34 7.44e-9 Brugada syndrome; CESC cis rs4808199 0.895 rs6511036 chr19:19582651 A/G cg03709012 chr19:19516395 GATAD2A 1.16 13.34 0.63 2.07e-31 Nonalcoholic fatty liver disease; CESC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg18032046 chr6:28092343 ZSCAN16 -0.59 -6.96 -0.39 2.71e-11 Parkinson's disease; CESC cis rs10791097 0.690 rs12286234 chr11:130730528 T/C cg09137382 chr11:130731461 NA 0.39 5.86 0.34 1.36e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs28489187 0.706 rs1498375 chr1:85787323 T/A cg16011679 chr1:85725395 C1orf52 0.56 6.55 0.37 3.05e-10 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.65 0.47 5.16e-16 Menopause (age at onset); CESC cis rs718433 0.584 rs2204935 chr14:22212463 A/G cg02257791 chr14:22217085 NA -0.32 -5.09 -0.3 6.83e-7 Intraocular pressure; CESC cis rs4319547 0.695 rs1803290 chr12:122865029 T/C cg05707623 chr12:122985044 ZCCHC8 0.53 5.92 0.34 1.01e-8 Body mass index; CESC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg18099408 chr3:52552593 STAB1 -0.43 -8.07 -0.44 2.45e-14 Electroencephalogram traits; CESC cis rs1707322 0.963 rs11211238 chr1:46449415 G/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg05332525 chr7:65337924 VKORC1L1 0.45 5.74 0.33 2.54e-8 Calcium levels; CESC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg22974920 chr21:40686053 BRWD1 -0.45 -5.57 -0.32 6.21e-8 Cognitive function; CESC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg17376030 chr22:41985996 PMM1 -0.79 -8.37 -0.46 3.43e-15 Vitiligo; CESC cis rs11098499 0.909 rs28714195 chr4:120316950 A/T cg24375607 chr4:120327624 NA 0.47 5.62 0.33 4.74e-8 Corneal astigmatism; CESC cis rs2816062 0.786 rs742486 chr1:18900829 G/A cg18795169 chr1:18902165 NA -0.93 -18.14 -0.74 2.24e-48 Urate levels in lean individuals; CESC cis rs11658309 1 rs11658309 chr17:17762247 T/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.54 -7.75 -0.43 1.97e-13 Strep throat; CESC cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.48 0.42 1.09e-12 Tonsillectomy; CESC cis rs7714584 1.000 rs9324660 chr5:150257054 C/G cg22134413 chr5:150180641 NA 0.5 5.81 0.34 1.81e-8 Crohn's disease; CESC cis rs9399401 0.667 rs6922607 chr6:142703483 A/G cg04461802 chr6:142623433 GPR126 0.37 5.55 0.32 6.88e-8 Chronic obstructive pulmonary disease; CESC cis rs3015497 0.753 rs12881776 chr14:51136330 T/G cg09863266 chr14:51125203 SAV1 -0.35 -5.39 -0.31 1.59e-7 Mean platelet volume; CESC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg19592336 chr6:28129416 ZNF389 0.6 7.98 0.44 4.4e-14 Depression; CESC cis rs4253772 0.550 rs9615953 chr22:46731024 C/G cg24881330 chr22:46731750 TRMU 0.8 5.7 0.33 3.13e-8 LDL cholesterol;Cholesterol, total; CESC cis rs738322 0.805 rs2016755 chr22:38539604 A/G cg25457927 chr22:38595422 NA -0.28 -5.18 -0.3 4.37e-7 Cutaneous nevi; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06059318 chr7:72936700 BAZ1B 0.48 6.08 0.35 4.27e-9 Gut microbiota (bacterial taxa); CESC cis rs12618769 0.597 rs7585939 chr2:99219206 T/A cg10123293 chr2:99228465 UNC50 0.4 5.19 0.3 4.2e-7 Bipolar disorder; CESC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg26314531 chr2:26401878 FAM59B -0.85 -9.49 -0.5 1.45e-18 Gut microbiome composition (summer); CESC trans rs2502399 0.689 rs7752798 chr6:113492470 G/A cg00285294 chr7:1089767 C7orf50 -0.33 -6.2 -0.36 2.2e-9 Plasma clusterin levels; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg19603075 chr15:89010536 MRPS11;MRPL46 -0.55 -6.27 -0.36 1.47e-9 Lung cancer in ever smokers; CESC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.59 -0.58 2.1e-25 Type 2 diabetes; CESC cis rs9611565 0.649 rs202614 chr22:41822150 A/C cg03806693 chr22:41940476 POLR3H 1.2 14.5 0.67 1.86e-35 Vitiligo; CESC cis rs6736093 0.966 rs4848899 chr2:112710111 G/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.46 -0.32 1.1e-7 Coronary artery disease; CESC cis rs72802342 0.541 rs185052 chr16:75467063 C/T cg04384234 chr16:75411784 CFDP1 0.5 5.93 0.34 9.67e-9 Advanced age-related macular degeneration; CESC cis rs6540556 0.643 rs2282739 chr1:209883001 C/T cg05527609 chr1:210001259 C1orf107 -0.48 -5.59 -0.32 5.56e-8 Red blood cell count; CESC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.81 0.39 6.56e-11 Platelet count; CESC cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.673 rs216409 chr17:28906269 C/T cg04154034 chr17:28927549 LRRC37B2 -0.65 -5.9 -0.34 1.09e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs62064224 0.902 rs17732573 chr17:30627664 C/T cg25809561 chr17:30822961 MYO1D -0.39 -5.27 -0.31 2.84e-7 Schizophrenia; CESC cis rs10870270 1.000 rs10159746 chr10:133742677 C/T cg08754478 chr10:133766260 PPP2R2D -0.62 -8.06 -0.44 2.63e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7084402 0.967 rs1658418 chr10:60333003 G/A cg07615347 chr10:60278583 BICC1 0.59 9.23 0.49 9.22e-18 Refractive error; CESC cis rs9925964 0.967 rs2855475 chr16:31147548 G/A cg02466173 chr16:30829666 NA -0.33 -5.15 -0.3 5.02e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4919694 0.572 rs4917995 chr10:104845443 A/T cg04362960 chr10:104952993 NT5C2 -0.65 -6.22 -0.36 1.94e-9 Arsenic metabolism; CESC cis rs6120849 0.802 rs6087681 chr20:33752896 G/C cg24642439 chr20:33292090 TP53INP2 0.61 6.49 0.37 4.21e-10 Protein C levels; CESC cis rs911555 0.755 rs8016676 chr14:103904842 C/A cg24130564 chr14:104152367 KLC1 0.5 6.52 0.37 3.62e-10 Intelligence (multi-trait analysis); CESC cis rs6120849 0.754 rs11167253 chr20:33614449 T/C cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.44 0.37 5.54e-10 Prudent dietary pattern; CESC cis rs7786808 0.579 rs4045391 chr7:158181826 T/C cg01191920 chr7:158217561 PTPRN2 -0.34 -5.57 -0.32 6.15e-8 Obesity-related traits; CESC cis rs2645694 0.532 rs2645706 chr4:77829606 A/C cg10057126 chr4:77819792 ANKRD56 0.58 8.31 0.45 4.97e-15 Emphysema distribution in smoking; CESC cis rs829883 0.934 rs1641642 chr12:98898726 A/G cg25150519 chr12:98850993 NA 0.7 9.63 0.51 5.03e-19 Colorectal adenoma (advanced); CESC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.77 -11.75 -0.59 6.15e-26 Age at first birth; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04691540 chr1:179198414 ABL2 0.5 6.59 0.38 2.32e-10 Gut microbiota (bacterial taxa); CESC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg22143856 chr6:28129313 ZNF389 0.53 6.86 0.39 4.9e-11 Depression; CESC cis rs909002 0.800 rs968335 chr1:32085776 G/A cg13919466 chr1:32135498 COL16A1 -0.46 -8.22 -0.45 8.97e-15 Intelligence (multi-trait analysis); CESC cis rs13102973 0.933 rs7656595 chr4:135875693 G/A cg14419869 chr4:135874104 NA 0.36 5.67 0.33 3.64e-8 Subjective well-being; CESC cis rs1348850 0.768 rs57681892 chr2:178357645 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.81 11.65 0.58 1.3e-25 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2243480 1.000 rs313799 chr7:65494330 A/G cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs13102973 0.932 rs7656273 chr4:135852678 G/A cg14419869 chr4:135874104 NA 0.33 5.13 0.3 5.56e-7 Subjective well-being; CESC cis rs4805272 0.512 rs7245724 chr19:29341679 C/T cg12756686 chr19:29218302 NA 0.43 5.86 0.34 1.37e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs733592 1.000 rs1859440 chr12:48427329 T/C cg24011408 chr12:48396354 COL2A1 -0.51 -8.17 -0.45 1.27e-14 Plateletcrit; CESC cis rs7216064 1.000 rs7214758 chr17:65880538 T/C cg12091567 chr17:66097778 LOC651250 -0.87 -8.96 -0.48 6.1e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs12190007 0.547 rs2981944 chr6:169801753 T/G cg15038512 chr6:170123185 PHF10 -0.48 -6.81 -0.39 6.6e-11 Obesity-related traits; CESC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.46 0.37 4.96e-10 Prudent dietary pattern; CESC cis rs3820928 1.000 rs9288617 chr2:227762815 G/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.72 -0.33 2.92e-8 Pulmonary function; CESC cis rs13031619 0.517 rs10183413 chr2:3684342 T/C cg01268866 chr2:3683757 COLEC11 -0.64 -6.87 -0.39 4.68e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC cis rs11098499 0.754 rs4107728 chr4:120253910 G/A cg09307838 chr4:120376055 NA 0.8 10.77 0.55 1.16e-22 Corneal astigmatism; CESC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg24829409 chr8:58192753 C8orf71 -0.5 -6.08 -0.35 4.13e-9 Developmental language disorder (linguistic errors); CESC cis rs9296095 0.632 rs6914422 chr6:33534880 A/G cg14003231 chr6:33640908 ITPR3 -0.32 -5.53 -0.32 7.81e-8 Platelet count; CESC trans rs634534 0.561 rs655744 chr11:65776585 G/T cg17712092 chr4:129076599 LARP1B -0.69 -9.49 -0.5 1.44e-18 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs4955124 0.558 rs78465094 chr3:32019016 T/C cg05935571 chr3:32023257 ZNF860;OSBPL10 0.97 8.8 0.48 1.83e-16 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06227920 chr15:65477998 CLPX -0.47 -6.31 -0.36 1.13e-9 Fibrinogen levels; CESC cis rs6460942 0.597 rs13227809 chr7:12525557 G/A cg20607287 chr7:12443886 VWDE -0.71 -7.67 -0.43 3.19e-13 Coronary artery disease; CESC cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg11657440 chr19:46296263 DMWD -0.59 -7.24 -0.41 4.94e-12 Coronary artery disease; CESC cis rs7312933 0.703 rs12370778 chr12:42599696 T/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.4 0.37 6.94e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs12220238 1.000 rs12358614 chr10:75906173 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.63 6.15 0.35 2.9e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg06601766 chr17:61851465 DDX42;CCDC47 -0.54 -6.65 -0.38 1.63e-10 Prudent dietary pattern; CESC cis rs9324022 0.722 rs17099613 chr14:101164715 T/A cg18089426 chr14:101175970 NA 0.59 5.34 0.31 2e-7 Plateletcrit; CESC cis rs6575793 0.512 rs6575791 chr14:101029203 A/G cg18516195 chr14:101012996 BEGAIN -0.42 -5.32 -0.31 2.19e-7 Menarche (age at onset); CESC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC trans rs11992162 0.551 rs59191504 chr8:11785081 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -6.11 -0.35 3.59e-9 Monocyte count; CESC trans rs4942242 1.000 rs7335094 chr13:44223936 T/C cg19169023 chr15:41853346 TYRO3 -0.45 -6.49 -0.37 4.12e-10 Response to tocilizumab in rheumatoid arthritis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03311606 chr2:173292277 ITGA6 -0.44 -6.28 -0.36 1.4e-9 Gambling; CESC cis rs8092503 1.000 rs12456731 chr18:52500292 C/T cg12377874 chr18:52495404 RAB27B 0.32 5.41 0.32 1.41e-7 Childhood body mass index; CESC cis rs6920965 0.507 rs7754833 chr6:126190894 A/G cg05901451 chr6:126070800 HEY2 -0.41 -5.29 -0.31 2.52e-7 High light scatter reticulocyte count; CESC cis rs9488822 0.676 rs12196579 chr6:116351724 G/T cg26893134 chr6:116381904 FRK 0.25 6.1 0.35 3.71e-9 Cholesterol, total;LDL cholesterol; CESC cis rs11638352 1.000 rs8038096 chr15:44367290 A/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.62 -5.96 -0.34 8.14e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs116095464 0.558 rs9312978 chr5:221930 C/G cg22857025 chr5:266934 NA -1.28 -14.18 -0.66 2.32e-34 Breast cancer; CESC cis rs727505 1.000 rs68091803 chr7:124526331 C/T cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.49e-13 Lewy body disease; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg07399355 chr1:155163013 MUC1 -0.51 -7.06 -0.4 1.48e-11 Height; CESC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg02725872 chr8:58115012 NA -0.42 -6.61 -0.38 2.1e-10 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg08470875 chr2:26401718 FAM59B 0.57 6.6 0.38 2.26e-10 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs1466236 chr3:40462162 C/T cg24209194 chr3:40518798 ZNF619 0.48 6.42 0.37 6.11e-10 Renal cell carcinoma; CESC cis rs561341 1.000 rs757009 chr17:30243937 A/G cg19193384 chr17:30244184 NA -0.49 -5.56 -0.32 6.53e-8 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.13 0.3 5.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 0.935 rs3114890 chr16:89449546 C/G cg08392591 chr16:89556376 ANKRD11 0.43 5.41 0.32 1.41e-7 Multiple myeloma (IgH translocation); CESC cis rs34172651 0.917 rs8043962 chr16:24781372 A/G cg06028605 chr16:24865363 SLC5A11 0.35 5.5 0.32 8.72e-8 Intelligence (multi-trait analysis); CESC cis rs2228479 0.717 rs2270460 chr16:89972416 C/A cg00800038 chr16:89945340 TCF25 -0.76 -7.12 -0.4 9.88e-12 Skin colour saturation; CESC cis rs9929218 0.551 rs2296408 chr16:68713823 A/C cg02972257 chr16:68554789 NA 0.44 5.51 0.32 8.36e-8 Colorectal cancer; CESC cis rs7208859 0.623 rs56018041 chr17:29059985 G/A cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7568498 0.564 rs9287807 chr2:161915361 T/C cg21518248 chr2:162101506 NA -0.48 -5.23 -0.31 3.52e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs12136530 0.577 rs4912002 chr1:19793402 G/T cg01832549 chr1:19774989 CAPZB -0.42 -5.82 -0.34 1.68e-8 Lead levels in blood; CESC cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.32 5.05 0.3 8.14e-7 Personality dimensions; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21830480 chr12:72057690 THAP2;ZFC3H1 0.46 6.1 0.35 3.74e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1045714 0.895 rs4721867 chr7:2643352 A/G cg20813462 chr7:2646259 IQCE -0.65 -5.68 -0.33 3.58e-8 Urate levels in lean individuals; CESC cis rs170557 0.597 rs6664500 chr1:210096295 C/T cg21951975 chr1:209979733 IRF6 -0.36 -5.05 -0.3 8.37e-7 Alopecia areata; CESC cis rs9287719 0.837 rs4331474 chr2:10755583 G/A cg00105475 chr2:10696890 NA 0.37 5.17 0.3 4.54e-7 Prostate cancer; CESC trans rs11039798 1.000 rs7131020 chr11:48642132 A/G cg15704280 chr7:45808275 SEPT13 0.66 6.3 0.36 1.24e-9 Axial length; CESC cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2980439 0.870 rs2945230 chr8:8109936 A/G cg15556689 chr8:8085844 FLJ10661 0.61 7.42 0.41 1.57e-12 Neuroticism; CESC cis rs761746 0.960 rs5753680 chr22:31930972 A/G cg25791279 chr22:32026902 PISD -0.54 -6.17 -0.35 2.52e-9 Intelligence; CESC cis rs10751667 0.961 rs7479171 chr11:926809 G/A cg06064525 chr11:970664 AP2A2 -0.44 -7.77 -0.43 1.72e-13 Alzheimer's disease (late onset); CESC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg05368731 chr17:41323189 NBR1 0.75 9.93 0.52 5.94e-20 Menopause (age at onset); CESC cis rs10242455 0.702 rs73713507 chr7:99138603 G/A cg25640893 chr7:99214727 ZNF498 0.79 5.58 0.32 6.05e-8 Blood metabolite levels; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg09426994 chr11:118478258 PHLDB1 -0.4 -6.09 -0.35 4.02e-9 Breast cancer; CESC cis rs6466055 0.720 rs1204060 chr7:104963064 T/C cg04380332 chr7:105027541 SRPK2 0.43 5.61 0.33 5.17e-8 Schizophrenia; CESC cis rs8028182 0.636 rs8030802 chr15:75813153 A/G cg20655648 chr15:75932815 IMP3 0.48 5.9 0.34 1.08e-8 Sudden cardiac arrest; CESC cis rs791888 0.760 rs10788561 chr10:89423245 A/G cg13926569 chr10:89418898 PAPSS2 0.55 7.83 0.43 1.2e-13 Magnesium levels; CESC cis rs9323205 0.953 rs11623710 chr14:51694261 C/T cg23942311 chr14:51606299 NA -0.42 -5.13 -0.3 5.57e-7 Cancer; CESC cis rs921968 0.591 rs13421421 chr2:219519286 A/G cg02176678 chr2:219576539 TTLL4 0.41 7.22 0.41 5.65e-12 Mean corpuscular hemoglobin concentration; CESC cis rs7095944 0.584 rs4962692 chr10:126424823 G/A cg08799069 chr10:126477246 METTL10 -0.39 -5.55 -0.32 6.81e-8 Asthma; CESC cis rs4975616 0.836 rs460073 chr5:1336459 T/C cg06550200 chr5:1325588 CLPTM1L -0.69 -10.71 -0.55 1.76e-22 Lung cancer; CESC cis rs66530629 0.874 rs6692599 chr1:25094714 T/C cg22509179 chr1:25234806 RUNX3 -0.44 -5.64 -0.33 4.27e-8 Plateletcrit; CESC cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg00149659 chr3:10157352 C3orf10 1.0 11.96 0.59 1.22e-26 Alzheimer's disease; CESC cis rs965469 1.000 rs6037526 chr20:3251248 T/C cg25506879 chr20:3388711 C20orf194 -0.59 -6.27 -0.36 1.48e-9 IFN-related cytopenia; CESC cis rs67311347 0.544 rs4974040 chr3:40331059 G/A cg24209194 chr3:40518798 ZNF619 0.38 5.25 0.31 3.05e-7 Renal cell carcinoma; CESC cis rs17021463 0.807 rs6847989 chr4:95277099 A/C cg11021082 chr4:95130006 SMARCAD1 0.42 6.52 0.37 3.49e-10 Testicular germ cell tumor; CESC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg04369109 chr6:150039330 LATS1 -0.41 -5.54 -0.32 7.36e-8 Lung cancer; CESC cis rs4595586 0.545 rs7958118 chr12:39376685 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg18765753 chr7:1198926 ZFAND2A -0.59 -9.39 -0.5 2.78e-18 Longevity;Endometriosis; CESC cis rs208520 0.526 rs9351542 chr6:66788571 A/G cg07460842 chr6:66804631 NA -1.11 -26.93 -0.86 8.11e-78 Exhaled nitric oxide output; CESC cis rs3741798 1.000 rs73277486 chr12:12494761 T/C cg08615371 chr12:12503544 MANSC1 0.81 5.83 0.34 1.59e-8 Cerebrospinal fluid biomarker levels; CESC cis rs9796 0.621 rs1659228 chr15:41471978 A/G cg12386646 chr15:41787261 ITPKA 0.33 5.08 0.3 7.11e-7 Menopause (age at onset); CESC cis rs6542838 0.609 rs13028500 chr2:99528296 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.49 -6.28 -0.36 1.41e-9 Fear of minor pain; CESC cis rs4555082 0.915 rs79048296 chr14:105754944 G/A cg06808227 chr14:105710500 BRF1 -0.58 -6.52 -0.37 3.47e-10 Mean platelet volume;Platelet distribution width; CESC cis rs926938 0.520 rs4140445 chr1:115291978 T/C cg12756093 chr1:115239321 AMPD1 -0.55 -6.73 -0.38 1.04e-10 Autism; CESC cis rs4727027 0.866 rs35599790 chr7:148806012 C/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.84 -0.39 5.49e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1355223 0.844 rs12809046 chr11:34748261 T/A cg11058730 chr11:34937778 PDHX;APIP -0.46 -5.94 -0.34 8.84e-9 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs17376456 1.000 rs67150649 chr5:93292377 A/G cg25358565 chr5:93447407 FAM172A 1.11 10.3 0.53 3.78e-21 Diabetic retinopathy; CESC cis rs12791968 0.917 rs11038238 chr11:45002010 A/G cg11846598 chr11:44996168 LOC221122 -0.56 -7.44 -0.42 1.37e-12 Inhibitory control; CESC cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.55 -0.42 6.87e-13 Alzheimer's disease; CESC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg06494592 chr3:125709126 NA -0.46 -5.19 -0.3 4.25e-7 Blood pressure (smoking interaction); CESC cis rs6060717 0.536 rs6060676 chr20:34498551 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -6.7 -0.38 1.22e-10 Hip circumference adjusted for BMI; CESC cis rs2730245 0.550 rs2709860 chr7:158651156 A/T cg24397884 chr7:158709396 WDR60 0.79 12.79 0.62 1.69e-29 Height; CESC cis rs1864400 0.690 rs2565200 chr10:43622933 A/G cg15436174 chr10:43711423 RASGEF1A -0.44 -5.28 -0.31 2.75e-7 Hirschsprung disease; CESC cis rs10504073 0.565 rs974780 chr8:49930976 G/A cg00325661 chr8:49890786 NA 0.56 8.46 0.46 1.8e-15 Blood metabolite ratios; CESC cis rs916888 0.779 rs430685 chr17:44859148 T/C cg15921436 chr17:44337874 NA -0.71 -8.07 -0.44 2.47e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10791097 0.694 rs7942621 chr11:130751308 C/G cg12179176 chr11:130786555 SNX19 0.66 10.42 0.54 1.61e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9858542 0.953 rs11711485 chr3:49491983 G/T cg03060546 chr3:49711283 APEH -0.54 -6.05 -0.35 4.83e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs637571 0.557 rs1204649 chr11:65702776 A/C cg17712092 chr4:129076599 LARP1B 0.74 10.19 0.53 8.94e-21 Eosinophil percentage of white cells; CESC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.21 0.57 3.99e-24 Alzheimer's disease; CESC cis rs6089584 1.000 rs6089587 chr20:60564829 C/T cg13770153 chr20:60521292 NA -0.45 -5.9 -0.34 1.12e-8 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16261398 chr11:1410750 BRSK2 0.56 6.0 0.35 6.38e-9 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg22800045 chr5:56110881 MAP3K1 0.83 9.46 0.5 1.7e-18 Initial pursuit acceleration; CESC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg07636037 chr3:49044803 WDR6 0.78 12.95 0.62 4.62e-30 Menarche (age at onset); CESC cis rs1395 0.778 rs11693660 chr2:27468856 T/C cg22903471 chr2:27725779 GCKR -0.43 -5.2 -0.3 4.04e-7 Blood metabolite levels; CESC cis rs17818399 0.716 rs62134741 chr2:46782189 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.5 -5.38 -0.31 1.62e-7 Height; CESC cis rs73110464 0.562 rs2363634 chr12:53354683 A/G cg05393297 chr12:53359155 NA -0.7 -9.94 -0.52 5.35e-20 Cancer (pleiotropy); CESC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -7.32 -0.41 2.93e-12 Alzheimer's disease; CESC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg26335602 chr6:28129616 ZNF389 0.44 5.66 0.33 3.97e-8 Parkinson's disease; CESC cis rs7116495 1.000 rs11235440 chr11:71826644 A/G cg26138937 chr11:71823887 C11orf51 0.79 6.6 0.38 2.2e-10 Severe influenza A (H1N1) infection; CESC cis rs72781680 0.898 rs72786270 chr2:24059049 G/A cg08917208 chr2:24149416 ATAD2B 0.95 8.74 0.47 2.69e-16 Lymphocyte counts; CESC cis rs3096299 0.754 rs3102382 chr16:89409742 C/G cg08822215 chr16:89438651 ANKRD11 -0.34 -5.05 -0.3 8.07e-7 Multiple myeloma (IgH translocation); CESC cis rs2742234 0.590 rs1254960 chr10:43699657 C/T cg07801480 chr10:43725741 RASGEF1A -0.41 -5.33 -0.31 2.14e-7 Hirschsprung disease; CESC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg07395648 chr5:131743802 NA -0.4 -5.22 -0.31 3.67e-7 Acylcarnitine levels; CESC cis rs8067545 0.586 rs2526459 chr17:20090042 G/T cg13482628 chr17:19912719 NA -0.41 -5.68 -0.33 3.5e-8 Schizophrenia; CESC cis rs9640161 0.711 rs60268791 chr7:150023800 G/T cg13722127 chr7:150037890 RARRES2 0.34 5.17 0.3 4.68e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12072290 chr12:124018993 RILPL1 -0.67 -8.48 -0.46 1.63e-15 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg18099408 chr3:52552593 STAB1 -0.31 -5.09 -0.3 6.68e-7 Bipolar disorder; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08052428 chr9:135996421 RALGDS 0.47 6.33 0.36 1.03e-9 Systemic lupus erythematosus; CESC trans rs1945213 0.694 rs7129022 chr11:55876132 A/G cg03929089 chr4:120376271 NA 0.78 7.5 0.42 9.59e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg17221315 chr6:27791827 HIST1H4J 0.53 5.07 0.3 7.52e-7 Lung cancer in ever smokers; CESC cis rs9948 0.655 rs76653480 chr2:97375549 C/T cg01990225 chr2:97406019 LMAN2L -0.92 -7.07 -0.4 1.36e-11 Erectile dysfunction and prostate cancer treatment; CESC cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg18876405 chr7:65276391 NA 0.69 9.58 0.51 7.2e-19 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09392819 chr2:26568944 SELI;GPR113 0.62 6.92 0.39 3.38e-11 Gut microbiome composition (summer); CESC cis rs4919694 0.536 rs12256506 chr10:104963618 T/A cg04362960 chr10:104952993 NT5C2 0.69 6.87 0.39 4.53e-11 Arsenic metabolism; CESC cis rs4704187 0.687 rs6891023 chr5:74500755 G/A cg03227963 chr5:74354835 NA 0.29 5.27 0.31 2.77e-7 Response to amphetamines; CESC cis rs3015497 0.631 rs17718908 chr14:51005213 A/G cg26011998 chr14:51135199 SAV1 0.48 5.54 0.32 7.41e-8 Mean platelet volume; CESC cis rs60843830 1.000 rs60149603 chr2:285421 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.89 11.9 0.59 1.88e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.64 0.47 5.23e-16 Menopause (age at onset); CESC cis rs12410462 0.681 rs79461024 chr1:227568783 G/T cg04117972 chr1:227635322 NA 0.75 6.21 0.36 2e-9 Major depressive disorder; CESC cis rs6831352 0.918 rs13127582 chr4:100058194 G/A cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg17971929 chr21:40555470 PSMG1 0.92 12.26 0.6 1.16e-27 Cognitive function; CESC trans rs61931739 0.517 rs12816252 chr12:34067693 G/A cg26384229 chr12:38710491 ALG10B 0.6 8.38 0.46 3.12e-15 Morning vs. evening chronotype; CESC cis rs4588572 0.644 rs10942856 chr5:77746199 A/G cg11547950 chr5:77652471 NA 0.39 5.37 0.31 1.72e-7 Triglycerides; CESC cis rs9399135 0.933 rs4559100 chr6:135324085 T/C cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs10129255 0.536 rs17113249 chr14:107134290 A/G cg23076370 chr14:107095027 NA -0.64 -9.84 -0.52 1.15e-19 Kawasaki disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21828663 chr7:6198703 USP42 -0.56 -6.31 -0.36 1.2e-9 Gut microbiome composition (summer); CESC cis rs1348850 0.914 rs1348849 chr2:178358072 C/T cg22681709 chr2:178499509 PDE11A -0.42 -6.06 -0.35 4.65e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs12291225 0.679 rs11605531 chr11:14291594 A/G cg19336497 chr11:14380999 RRAS2 -0.37 -5.37 -0.31 1.68e-7 Sense of smell; CESC cis rs909674 0.690 rs5750823 chr22:39829973 C/T cg05872129 chr22:39784769 NA -0.75 -10.19 -0.53 8.35e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs9513593 1.000 rs9513593 chr13:99950260 G/A cg21788972 chr13:99853209 UBAC2 -0.56 -6.73 -0.38 1.02e-10 Psoriasis; CESC cis rs6500395 0.962 rs1115759 chr16:48599530 A/G cg04672837 chr16:48644449 N4BP1 0.44 5.28 0.31 2.66e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs2180341 0.618 rs12210968 chr6:127596985 A/G cg24812749 chr6:127587940 RNF146 0.59 8.02 0.44 3.42e-14 Breast cancer; CESC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg00121533 chr1:75199117 CRYZ;TYW3 -0.52 -7.06 -0.4 1.43e-11 Resistin levels; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg08078366 chr3:50375349 RASSF1 -0.47 -6.09 -0.35 3.99e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg13902645 chr11:5959945 NA -0.68 -10.46 -0.54 1.14e-21 DNA methylation (variation); CESC cis rs941873 0.803 rs5015119 chr10:81101609 G/C cg08514558 chr10:81106712 PPIF 0.36 6.13 0.35 3.2e-9 Height; CESC trans rs3780486 1.000 rs12342831 chr9:33124872 A/G cg04842962 chr6:43655489 MRPS18A 0.9 13.75 0.65 7.82e-33 IgG glycosylation; CESC cis rs4141404 0.923 rs2413046 chr22:31665909 C/A cg13145458 chr22:31556086 RNF185 0.48 5.35 0.31 1.88e-7 Paclitaxel-induced neuropathy; CESC cis rs17253792 0.822 rs10483643 chr14:56089931 G/C cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs826838 0.967 rs826870 chr12:39120250 G/A cg13010199 chr12:38710504 ALG10B -0.46 -6.44 -0.37 5.5e-10 Heart rate; CESC cis rs7618501 1.000 rs3811696 chr3:49761605 C/T cg24308560 chr3:49941425 MST1R 0.51 7.06 0.4 1.48e-11 Intelligence (multi-trait analysis); CESC cis rs7726839 0.540 rs72703083 chr5:595365 C/T cg16447950 chr5:562315 NA -0.6 -6.04 -0.35 5.24e-9 Obesity-related traits; CESC cis rs9916302 0.706 rs7212621 chr17:37527911 T/G cg07936489 chr17:37558343 FBXL20 0.88 9.52 0.5 1.1e-18 Glomerular filtration rate (creatinine); CESC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg24881330 chr22:46731750 TRMU 0.78 6.83 0.39 5.79e-11 LDL cholesterol;Cholesterol, total; CESC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg02569458 chr12:86230093 RASSF9 0.47 6.95 0.39 2.79e-11 Major depressive disorder; CESC cis rs637571 0.726 rs689274 chr11:65665988 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.64 -8.3 -0.45 5.35e-15 Eosinophil percentage of white cells; CESC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.66 9.34 0.5 4.25e-18 Menopause (age at onset); CESC cis rs12930096 1.000 rs8050192 chr16:11678582 C/T cg07439791 chr16:11680400 LITAF 0.61 5.64 0.33 4.42e-8 QT interval; CESC cis rs738322 0.934 rs133016 chr22:38572582 C/T cg25457927 chr22:38595422 NA -0.3 -5.46 -0.32 1.1e-7 Cutaneous nevi; CESC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg13607699 chr17:42295918 UBTF 0.55 6.73 0.38 1.07e-10 Total body bone mineral density; CESC cis rs10870270 1.000 rs10430617 chr10:133748889 T/C cg08754478 chr10:133766260 PPP2R2D -0.61 -7.98 -0.44 4.32e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs5769765 0.865 rs4824108 chr22:50271428 A/G cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.42 6.18 0.35 2.44e-9 Total body bone mineral density; CESC cis rs9868809 0.881 rs13063312 chr3:48661985 G/A cg07636037 chr3:49044803 WDR6 -0.64 -5.29 -0.31 2.55e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs9581857 0.685 rs10467687 chr13:28036516 G/A cg01674679 chr13:27998804 GTF3A -0.68 -5.52 -0.32 7.95e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7216064 0.953 rs4791300 chr17:65930772 A/G cg07042672 chr17:66097459 LOC651250 -0.59 -7.11 -0.4 1.09e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19606431 chr6:131949205 MED23 0.54 6.64 0.38 1.79e-10 Gut microbiome composition (summer); CESC cis rs644799 0.511 rs12791736 chr11:95475399 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.48 6.11 0.35 3.57e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg16049864 chr8:95962084 TP53INP1 -0.67 -12.02 -0.59 7.22e-27 Type 2 diabetes; CESC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg25072359 chr17:41440525 NA 0.43 5.78 0.33 2.04e-8 Menopause (age at onset); CESC cis rs2624839 0.629 rs2526397 chr3:50187790 A/C cg24110177 chr3:50126178 RBM5 0.46 5.85 0.34 1.44e-8 Intelligence (multi-trait analysis); CESC trans rs1545843 0.593 rs10862854 chr12:84773155 C/A cg03015433 chr16:56623111 MT3 -0.33 -6.0 -0.35 6.34e-9 Major depressive disorder; CESC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg22903657 chr4:1355424 KIAA1530 -0.38 -5.23 -0.31 3.51e-7 Obesity-related traits; CESC trans rs11992162 0.636 rs13265816 chr8:11797485 G/A cg15556689 chr8:8085844 FLJ10661 0.51 6.35 0.36 9.34e-10 Monocyte count; CESC trans rs10209086 0.736 rs1584436 chr2:138298878 A/G cg26879696 chr10:114206778 VTI1A;ZDHHC6 0.49 6.18 0.35 2.44e-9 Multiple system atrophy; CESC cis rs617791 0.530 rs10791835 chr11:65750924 C/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.14 -0.3 5.29e-7 Breast cancer; CESC cis rs1348850 0.651 rs1901824 chr2:178225466 T/C cg23306229 chr2:178417860 TTC30B 0.54 6.99 0.39 2.2e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8114671 0.527 rs6060112 chr20:33489276 A/T cg07148914 chr20:33460835 GGT7 0.52 6.79 0.39 7.24e-11 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19092105 chr15:85383079 ALPK3 0.47 6.3 0.36 1.26e-9 Fibrinogen levels; CESC cis rs11642862 0.685 rs79974799 chr16:30996795 C/T cg02466173 chr16:30829666 NA -0.57 -5.21 -0.3 3.81e-7 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10424330 chr16:71894309 ZNF821;ATXN1L -0.7 -7.56 -0.42 6.76e-13 Gut microbiome composition (summer); CESC cis rs4727963 0.846 rs1525484 chr7:122702980 G/T cg03640110 chr7:122635026 TAS2R16 -0.37 -5.7 -0.33 3.11e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.81 0.39 6.61e-11 Bipolar disorder; CESC cis rs3015497 0.789 rs2356457 chr14:51116863 C/T cg09863266 chr14:51125203 SAV1 -0.34 -5.34 -0.31 2.05e-7 Mean platelet volume; CESC cis rs6121246 0.529 rs6060195 chr20:30185638 C/T cg13852791 chr20:30311386 BCL2L1 0.58 5.56 0.32 6.65e-8 Mean corpuscular hemoglobin; CESC cis rs75804782 0.521 rs56373856 chr2:239437926 C/T cg18131467 chr2:239335373 ASB1 -0.68 -5.18 -0.3 4.38e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg10295955 chr4:187884368 NA -0.72 -11.18 -0.57 5.02e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg03709012 chr19:19516395 GATAD2A -0.95 -13.98 -0.65 1.22e-33 Tonsillectomy; CESC cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg03060546 chr3:49711283 APEH 0.45 5.48 0.32 9.77e-8 Parkinson's disease; CESC cis rs9815354 0.680 rs10510730 chr3:41849013 C/G cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs116095464 0.558 rs60251075 chr5:245292 T/C cg22857025 chr5:266934 NA -1.27 -18.37 -0.75 3.49e-49 Breast cancer; CESC cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg03709012 chr19:19516395 GATAD2A 0.89 12.31 0.6 7.6e-28 Tonsillectomy; CESC cis rs7216064 1.000 rs11869819 chr17:65868669 A/C cg07042672 chr17:66097459 LOC651250 -0.54 -5.59 -0.32 5.61e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10899021 0.920 rs7112384 chr11:74348205 T/G cg25880958 chr11:74394337 NA -0.75 -7.78 -0.43 1.6e-13 Response to metformin (IC50); CESC cis rs4853012 0.887 rs2280642 chr2:74358252 T/A cg05776053 chr2:74358815 NA 0.43 5.07 0.3 7.45e-7 Gestational age at birth (maternal effect); CESC cis rs7208859 0.623 rs216434 chr17:28922335 G/C cg19761014 chr17:28927070 LRRC37B2 0.87 6.7 0.38 1.21e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2243480 1.000 rs464895 chr7:65527106 A/G cg13147721 chr7:65941812 NA -0.91 -9.0 -0.48 4.55e-17 Diabetic kidney disease; CESC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.15 0.81 3.07e-62 Prudent dietary pattern; CESC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg07507251 chr3:52567010 NT5DC2 0.33 5.74 0.33 2.65e-8 Electroencephalogram traits; CESC cis rs3806843 1.000 rs1030164 chr5:140185272 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -5.28 -0.31 2.74e-7 Depressive symptoms (multi-trait analysis); CESC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14703032 chr6:3140546 BPHL 0.46 6.42 0.37 6.12e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09526122 chr4:1828794 LETM1 -0.53 -6.31 -0.36 1.17e-9 Gut microbiome composition (summer); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg26040332 chr1:27960788 FGR 0.52 6.31 0.36 1.15e-9 Psoriatic arthritis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22654940 chr2:54856752 SPTBN1 0.53 7.36 0.41 2.3e-12 Fibrinogen levels; CESC cis rs10927875 0.722 rs945425 chr1:16348412 T/C cg22431228 chr1:16359049 CLCNKA -0.51 -8.37 -0.46 3.39e-15 Dilated cardiomyopathy; CESC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg25036284 chr2:26402008 FAM59B -0.57 -6.58 -0.37 2.57e-10 Gut microbiome composition (summer); CESC cis rs2795502 1.000 rs2795496 chr10:43337842 G/A cg20628663 chr10:43360327 NA -0.63 -7.43 -0.42 1.5e-12 Blood protein levels; CESC cis rs9611565 0.573 rs9306355 chr22:42111896 A/T cg06481639 chr22:41940642 POLR3H 0.48 5.58 0.32 6.02e-8 Vitiligo; CESC cis rs1048238 0.506 rs598371 chr1:16212739 G/A cg22431228 chr1:16359049 CLCNKA 0.36 6.21 0.36 2.03e-9 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10272801 chr16:14013773 ERCC4 0.58 6.49 0.37 4.28e-10 Gut microbiome composition (summer); CESC cis rs2066819 1.000 rs77768890 chr12:56725121 A/G cg26804944 chr12:56660921 COQ10A -0.85 -5.12 -0.3 5.95e-7 Psoriasis vulgaris; CESC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg02475777 chr4:1388615 CRIPAK 0.75 9.38 0.5 3.03e-18 Longevity; CESC trans rs11989744 0.597 rs2033788 chr8:23574847 G/T cg03492747 chr16:86543808 FOXF1 -0.82 -13.05 -0.63 2.17e-30 Waist-hip ratio; CESC cis rs7799006 0.606 rs12669625 chr7:2315950 C/T cg08027265 chr7:2291960 NA -0.57 -9.66 -0.51 4.16e-19 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg04772025 chr11:68637568 NA 0.51 6.21 0.36 2.09e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg19046167 chr17:80928561 B3GNTL1 0.41 5.42 0.32 1.33e-7 Breast cancer; CESC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg07092213 chr7:1199455 ZFAND2A -0.43 -5.78 -0.33 2.08e-8 Longevity;Endometriosis; CESC cis rs16854884 0.586 rs4561830 chr3:143735572 C/T cg06585982 chr3:143692056 C3orf58 0.5 6.64 0.38 1.73e-10 Economic and political preferences (feminism/equality); CESC cis rs250677 0.917 rs36066 chr5:148419771 A/G cg18129178 chr5:148520854 ABLIM3 -0.5 -5.45 -0.32 1.14e-7 Breast cancer; CESC cis rs1322639 0.614 rs6903921 chr6:169563957 C/T cg04662567 chr6:169592167 NA -0.5 -5.26 -0.31 2.93e-7 Pulse pressure; CESC cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg25517755 chr10:38738941 LOC399744 -0.47 -6.05 -0.35 4.86e-9 Extrinsic epigenetic age acceleration; CESC trans rs9325144 0.560 rs10785573 chr12:38654166 G/A cg23762105 chr12:34175262 ALG10 0.48 6.31 0.36 1.15e-9 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01694628 chr15:25478725 SNORD115-35 -0.54 -6.85 -0.39 5.18e-11 Gut microbiome composition (summer); CESC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg13628971 chr7:2884303 GNA12 0.62 8.51 0.46 1.27e-15 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05808815 chr1:54666250 CYB5RL;MRPL37 -0.37 -6.07 -0.35 4.5e-9 Gambling; CESC cis rs7236492 0.748 rs11663658 chr18:77197555 T/C cg15644404 chr18:77186268 NFATC1 -0.69 -5.39 -0.31 1.55e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs1005277 0.522 rs289649 chr10:37975384 T/C cg25517755 chr10:38738941 LOC399744 -0.41 -5.35 -0.31 1.88e-7 Extrinsic epigenetic age acceleration; CESC cis rs7264396 0.512 rs2425072 chr20:34293686 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.87 0.39 4.6e-11 Total cholesterol levels; CESC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg19622623 chr12:86230825 RASSF9 -0.46 -5.88 -0.34 1.22e-8 Major depressive disorder; CESC cis rs8072100 0.905 rs9901869 chr17:45575206 G/A cg08085267 chr17:45401833 C17orf57 -0.47 -6.22 -0.36 1.94e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1062177 1.000 rs2915887 chr5:151205504 C/T cg12924095 chr5:151150029 G3BP1 0.5 6.43 0.37 5.81e-10 Preschool internalizing problems; CESC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg12310025 chr6:25882481 NA -0.44 -6.43 -0.37 5.77e-10 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00622658 chr8:10469796 RP1L1 0.43 6.41 0.37 6.74e-10 Fibrinogen levels; CESC cis rs854765 0.583 rs11650890 chr17:17790882 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.49 -6.25 -0.36 1.6e-9 Total body bone mineral density; CESC cis rs2832191 0.791 rs2832178 chr21:30479858 T/G cg08807101 chr21:30365312 RNF160 -0.77 -11.15 -0.56 6.51e-24 Dental caries; CESC cis rs7617480 0.648 rs9864243 chr3:48982732 G/A cg06212747 chr3:49208901 KLHDC8B 0.54 5.97 0.34 7.63e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); CESC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg09365446 chr1:150670422 GOLPH3L 0.42 5.98 0.34 7.35e-9 Tonsillectomy; CESC cis rs35110281 0.693 rs3819161 chr21:45092653 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -8.72 -0.47 3.14e-16 Mean corpuscular volume; CESC cis rs2204008 0.811 rs8189445 chr12:38276295 T/C cg13010199 chr12:38710504 ALG10B 0.48 6.04 0.35 5.23e-9 Bladder cancer; CESC cis rs713587 1.000 rs713587 chr2:25158281 C/T cg01884057 chr2:25150051 NA 0.42 7.97 0.44 4.67e-14 Body mass index in non-asthmatics; CESC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs11112613 0.775 rs7299470 chr12:105961773 G/A cg03607813 chr12:105948248 NA 0.61 7.42 0.41 1.56e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs9488822 0.676 rs10456902 chr6:116333742 C/G cg18764771 chr6:116381957 FRK -0.22 -5.53 -0.32 7.61e-8 Cholesterol, total;LDL cholesterol; CESC cis rs1546924 0.570 rs197415 chr1:112311593 C/T cg23955903 chr1:112298873 DDX20;C1orf183 0.43 5.55 0.32 6.95e-8 Body mass index; CESC cis rs4242434 0.927 rs2272718 chr8:22457388 G/A cg03733263 chr8:22462867 KIAA1967 0.97 13.98 0.65 1.18e-33 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs1577917 1.000 rs1337850 chr6:86729103 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.17 -0.35 2.58e-9 Response to antipsychotic treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08668662 chr20:30539908 PDRG1 0.56 6.73 0.38 1.05e-10 Gut microbiome composition (summer); CESC cis rs9635726 0.638 rs2952155 chr17:37861718 T/C cg20243544 chr17:37824526 PNMT 0.66 7.05 0.4 1.59e-11 Primary biliary cholangitis; CESC cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg12927641 chr6:109611667 NA -0.41 -6.17 -0.35 2.49e-9 Reticulocyte fraction of red cells; CESC cis rs2712431 0.554 rs2010054 chr3:128305302 A/G cg16766828 chr3:128327626 NA -0.36 -5.96 -0.34 8.1e-9 Monocyte chemoattractant protein-1 levels; CESC cis rs11645898 0.935 rs72787094 chr16:72192613 C/A cg14768367 chr16:72042858 DHODH -0.79 -6.58 -0.37 2.51e-10 Blood protein levels; CESC cis rs11148252 0.574 rs9536247 chr13:53279542 T/C cg00495681 chr13:53174319 NA 0.62 8.56 0.47 9.42e-16 Lewy body disease; CESC cis rs11871801 0.718 rs34967087 chr17:40576816 A/C cg21433558 chr17:40837037 CNTNAP1 0.48 5.33 0.31 2.11e-7 Crohn's disease; CESC cis rs8038465 0.615 rs6495076 chr15:73982965 G/A cg15420318 chr15:73925796 NPTN 0.52 7.94 0.44 5.93e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg11764359 chr7:65958608 NA 0.96 15.25 0.68 3.95e-38 Aortic root size; CESC cis rs4481887 1.000 rs10788775 chr1:248471945 C/G cg00666640 chr1:248458726 OR2T12 0.38 6.32 0.36 1.11e-9 Common traits (Other); CESC cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg10556349 chr10:835070 NA 0.56 5.26 0.31 2.9e-7 Eosinophil percentage of granulocytes; CESC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.32 -5.84 -0.34 1.52e-8 Electroencephalogram traits; CESC cis rs13034020 0.522 rs12996059 chr2:61245551 G/C cg18625361 chr2:61244694 PEX13;PUS10 0.66 5.9 0.34 1.13e-8 Hodgkin's lymphoma; CESC cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg18196295 chr10:418757 DIP2C 0.4 5.38 0.31 1.67e-7 Psychosis in Alzheimer's disease; CESC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg02297831 chr4:17616191 MED28 0.6 7.51 0.42 9.14e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7044106 0.718 rs10616 chr9:123363533 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.78 11.64 0.58 1.48e-25 Hip circumference adjusted for BMI; CESC cis rs7089973 0.872 rs12773943 chr10:116631184 G/A cg25233709 chr10:116636983 FAM160B1 0.34 5.06 0.3 7.68e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2295359 0.892 rs72676069 chr1:67658954 T/C cg03340356 chr1:67600835 NA 0.32 5.26 0.31 2.93e-7 Psoriasis; CESC cis rs6736093 0.966 rs13013340 chr2:112694988 C/A cg12686935 chr2:112915763 FBLN7 -0.43 -5.56 -0.32 6.75e-8 Coronary artery disease; CESC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg17376030 chr22:41985996 PMM1 0.75 7.88 0.44 8.52e-14 Crohn's disease;Inflammatory bowel disease; CESC cis rs4803468 1.000 rs2241708 chr19:41912270 C/T cg09537434 chr19:41945824 ATP5SL -1.04 -18.47 -0.75 1.65e-49 Height; CESC cis rs9902453 0.619 rs2617866 chr17:28076217 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.78 -10.44 -0.54 1.34e-21 Coffee consumption (cups per day); CESC cis rs2859741 0.587 rs510969 chr1:37475061 T/C cg09363841 chr1:37513479 NA -0.49 -6.75 -0.38 9.25e-11 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs8060686 0.641 rs116821144 chr16:68081341 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.12 -0.35 3.44e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs7264396 0.635 rs3827030 chr20:34474947 C/T cg23207816 chr20:34252616 CPNE1;RBM12 -0.63 -7.2 -0.4 6.07e-12 Total cholesterol levels; CESC cis rs3857536 0.611 rs6927407 chr6:66870010 T/C cg07460842 chr6:66804631 NA -0.54 -7.02 -0.4 1.89e-11 Blood trace element (Cu levels); CESC cis rs59698941 0.943 rs57880964 chr5:132210674 G/C cg02081065 chr5:132209139 LEAP2 -0.52 -5.11 -0.3 6.08e-7 Apolipoprotein A-IV levels; CESC cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg21138405 chr5:131827807 IRF1 0.54 9.64 0.51 4.83e-19 Asthma (sex interaction); CESC cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg04455712 chr21:45112962 RRP1B 0.38 5.59 0.32 5.78e-8 Mean corpuscular volume; CESC cis rs10876993 0.784 rs1871417 chr12:58018979 C/T cg18357645 chr12:58087776 OS9 -0.55 -8.5 -0.46 1.39e-15 Celiac disease or Rheumatoid arthritis; CESC cis rs2439831 0.867 rs4583210 chr15:43660925 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.19 0.63 6.83e-31 Lung cancer in ever smokers; CESC cis rs12995491 0.933 rs13023008 chr2:88530933 G/A cg18490616 chr2:88469792 THNSL2 -0.53 -7.91 -0.44 6.92e-14 Response to metformin (IC50); CESC cis rs34779708 0.733 rs7083266 chr10:35541632 C/A cg03585969 chr10:35415529 CREM 0.56 6.42 0.37 6.15e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs7216064 1.000 rs1976054 chr17:65833224 T/G cg12091567 chr17:66097778 LOC651250 -0.78 -8.85 -0.48 1.31e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs1994135 0.647 rs67243558 chr12:33695383 T/C cg26384229 chr12:38710491 ALG10B 0.46 6.37 0.36 8.12e-10 Resting heart rate; CESC cis rs6460942 0.915 rs7802454 chr7:12454508 A/G cg02935154 chr7:12443704 VWDE -0.58 -6.16 -0.35 2.73e-9 Coronary artery disease; CESC cis rs11650494 0.710 rs73987294 chr17:47474730 T/C cg08112188 chr17:47440006 ZNF652 0.83 6.31 0.36 1.17e-9 Prostate cancer; CESC cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg11812906 chr14:75593930 NEK9 -0.87 -14.17 -0.66 2.62e-34 Height; CESC cis rs9300255 0.537 rs1618679 chr12:123650714 A/G cg19016782 chr12:123741754 C12orf65 -0.4 -5.77 -0.33 2.27e-8 Neutrophil percentage of white cells; CESC cis rs796364 0.806 rs79053279 chr2:201057443 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.78 -6.47 -0.37 4.64e-10 Schizophrenia; CESC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.47 -0.32 1.06e-7 Aortic root size; CESC cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg05234568 chr11:5960015 NA -0.43 -5.07 -0.3 7.64e-7 DNA methylation (variation); CESC cis rs7512552 0.839 rs698916 chr1:150388385 A/G cg15654264 chr1:150340011 RPRD2 0.4 5.3 0.31 2.4e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg18230493 chr5:56204884 C5orf35 0.43 5.03 0.3 9.04e-7 Coronary artery disease; CESC cis rs11785400 0.793 rs11785012 chr8:143748355 G/A cg10596483 chr8:143751796 JRK 0.43 5.37 0.31 1.69e-7 Schizophrenia; CESC cis rs2797160 0.651 rs6569437 chr6:126034540 T/G cg05901451 chr6:126070800 HEY2 0.51 7.47 0.42 1.19e-12 Endometrial cancer; CESC cis rs4253772 0.550 rs9615953 chr22:46731024 C/G cg10541313 chr22:46663664 TTC38 0.73 5.21 0.3 3.86e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg26408565 chr15:76604113 ETFA -0.41 -6.21 -0.36 2e-9 Blood metabolite levels; CESC trans rs7819412 0.645 rs4841508 chr8:11065003 C/A cg06636001 chr8:8085503 FLJ10661 -0.57 -6.58 -0.37 2.57e-10 Triglycerides; CESC cis rs3820068 0.603 rs72647118 chr1:15956535 G/T cg16988262 chr1:15930761 NA 0.34 5.43 0.32 1.24e-7 Systolic blood pressure; CESC cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.53 -5.34 -0.31 2.01e-7 Cerebrospinal P-tau181p levels; CESC cis rs2243480 1.000 rs4718316 chr7:65648731 A/G cg12463550 chr7:65579703 CRCP -0.73 -5.66 -0.33 4.03e-8 Diabetic kidney disease; CESC cis rs9649465 0.561 rs600081 chr7:123414591 A/T cg03229431 chr7:123269106 ASB15 0.4 5.58 0.32 5.96e-8 Migraine; CESC cis rs72781680 0.566 rs6713979 chr2:23899876 A/G cg20701182 chr2:24300061 SF3B14 0.64 6.54 0.37 3.13e-10 Lymphocyte counts; CESC cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg03467027 chr4:99064603 C4orf37 -0.48 -5.91 -0.34 1.04e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9291683 0.561 rs3733584 chr4:10036506 T/C cg11266682 chr4:10021025 SLC2A9 0.7 13.81 0.65 4.81e-33 Bone mineral density; CESC cis rs9900062 0.560 rs11656678 chr17:62681505 G/A cg02598441 chr17:62777298 LOC146880 -0.63 -6.97 -0.39 2.5e-11 QT interval; CESC cis rs11031096 0.568 rs10767891 chr11:4234524 A/G cg18678763 chr11:4115507 RRM1 -0.37 -5.07 -0.3 7.36e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs72945132 0.882 rs7942613 chr11:70210675 C/T cg00319359 chr11:70116639 PPFIA1 0.71 6.85 0.39 5.11e-11 Coronary artery disease; CESC cis rs6546550 0.901 rs13015457 chr2:70125763 G/T cg02498382 chr2:70120550 SNRNP27 -0.4 -7.03 -0.4 1.71e-11 Prevalent atrial fibrillation; CESC trans rs208520 0.690 rs851459 chr6:66813989 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.97 -12.84 -0.62 1.19e-29 Exhaled nitric oxide output; CESC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.88 11.34 0.57 1.46e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9362426 0.503 rs6454609 chr6:88106028 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.42 5.05 0.3 8.34e-7 Depressive episodes in bipolar disorder; CESC cis rs7255436 0.965 rs11668346 chr19:8450854 A/T cg10174797 chr19:8464628 RAB11B 0.39 5.57 0.32 6.11e-8 HDL cholesterol; CESC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg00149659 chr3:10157352 C3orf10 0.71 8.4 0.46 2.72e-15 Alzheimer's disease; CESC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg16590910 chr6:42928470 GNMT 0.36 5.06 0.3 7.99e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4268898 1.000 rs4268898 chr2:24490413 C/T cg06627628 chr2:24431161 ITSN2 0.68 8.24 0.45 7.99e-15 Asthma; CESC cis rs651907 0.557 rs7629753 chr3:101371922 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.51 -6.93 -0.39 3.1e-11 Colorectal cancer; CESC cis rs17039065 0.920 rs1595198 chr4:109472351 A/C cg16022748 chr4:109541635 LOC285456;RPL34 0.66 5.78 0.33 2.11e-8 Gut microbiome composition (summer); CESC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg02931644 chr1:25747376 RHCE 0.47 7.99 0.44 4.14e-14 Erythrocyte sedimentation rate; CESC cis rs6500602 0.702 rs6500606 chr16:4502514 A/G cg08645402 chr16:4508243 NA -0.49 -7.84 -0.43 1.07e-13 Schizophrenia; CESC cis rs4474465 0.790 rs10899541 chr11:78245573 A/G cg27205649 chr11:78285834 NARS2 -0.47 -5.92 -0.34 9.7e-9 Alzheimer's disease (survival time); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18165186 chr3:50314180 SEMA3B -0.65 -7.06 -0.4 1.47e-11 Gut microbiome composition (summer); CESC cis rs60154123 0.615 rs701943 chr1:210425727 A/G cg23283495 chr1:209979779 IRF6 -0.43 -5.68 -0.33 3.48e-8 Coronary artery disease; CESC cis rs4654899 0.758 rs2874367 chr1:21324491 A/C cg05370193 chr1:21551575 ECE1 -0.38 -5.71 -0.33 3.04e-8 Superior frontal gyrus grey matter volume; CESC cis rs1005277 0.522 rs289645 chr10:37943642 T/C cg25427524 chr10:38739819 LOC399744 -0.63 -8.98 -0.48 5.02e-17 Extrinsic epigenetic age acceleration; CESC cis rs3806843 0.735 rs778597 chr5:140040665 A/G cg26395211 chr5:140044315 WDR55 -0.48 -6.21 -0.36 2.09e-9 Depressive symptoms (multi-trait analysis); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg04279939 chr12:10876163 CSDA -0.43 -6.01 -0.35 6.17e-9 Height; CESC cis rs977987 0.832 rs37597 chr16:75500275 T/G cg03315344 chr16:75512273 CHST6 -0.48 -6.7 -0.38 1.24e-10 Dupuytren's disease; CESC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg23281280 chr6:28129359 ZNF389 0.58 8.05 0.44 2.72e-14 Parkinson's disease; CESC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg18876405 chr7:65276391 NA -0.5 -6.78 -0.38 7.91e-11 Aortic root size; CESC cis rs4253772 0.550 rs6007779 chr22:46678615 A/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.78 9.39 0.5 2.94e-18 LDL cholesterol;Cholesterol, total; CESC cis rs11734570 0.581 rs76682731 chr4:38586045 T/C cg18361445 chr4:38666374 KLF3;FLJ13197 0.59 6.78 0.38 7.63e-11 Inflammatory bowel disease;Crohn's disease; CESC cis rs9911578 1.000 rs6503870 chr17:56659018 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -6.83 -0.39 5.7e-11 Intelligence (multi-trait analysis); CESC cis rs2228479 0.850 rs1800344 chr16:89816367 T/G cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs1707322 0.752 rs6703748 chr1:46095976 G/A cg06784218 chr1:46089804 CCDC17 0.4 6.97 0.39 2.52e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8111998 0.826 rs10421310 chr19:22768069 G/A cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg06943149 chr12:77157476 ZDHHC17 0.44 6.06 0.35 4.57e-9 Systemic lupus erythematosus; CESC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg18446336 chr7:2847575 GNA12 -0.4 -6.15 -0.35 2.86e-9 Height; CESC cis rs523522 0.962 rs11065149 chr12:120956963 G/A cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10089324 chr1:51984752 EPS15 -0.43 -6.22 -0.36 1.91e-9 Gambling; CESC cis rs826838 0.510 rs10876149 chr12:39228083 C/G cg26384229 chr12:38710491 ALG10B -0.68 -10.12 -0.53 1.44e-20 Heart rate; CESC cis rs10751667 0.643 rs10751666 chr11:941933 C/T cg06064525 chr11:970664 AP2A2 -0.5 -10.04 -0.52 2.7e-20 Alzheimer's disease (late onset); CESC trans rs35110281 0.748 rs2838322 chr21:44998615 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 7.42 0.41 1.59e-12 Mean corpuscular volume; CESC cis rs12681288 0.676 rs4565481 chr8:1001944 C/T cg15309053 chr8:964076 NA 0.4 6.68 0.38 1.36e-10 Schizophrenia; CESC cis rs7917772 0.582 rs11191352 chr10:104372244 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.39 5.41 0.32 1.43e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs41271473 0.500 rs4440831 chr1:228887522 C/T cg00850481 chr1:228891306 NA 0.48 6.81 0.39 6.7e-11 Chronic lymphocytic leukemia; CESC cis rs1348850 0.567 rs1405714 chr2:178538584 A/G cg23306229 chr2:178417860 TTC30B -0.52 -6.59 -0.38 2.38e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2404602 0.735 rs11638767 chr15:76655938 T/C cg23625390 chr15:77176239 SCAPER -0.42 -5.66 -0.33 3.94e-8 Blood metabolite levels; CESC cis rs9361491 0.580 rs13204088 chr6:79757438 A/C cg05283184 chr6:79620031 NA -0.38 -5.6 -0.33 5.47e-8 Intelligence (multi-trait analysis); CESC cis rs7927771 0.524 rs12226431 chr11:47805856 G/A cg18512352 chr11:47633146 NA 0.34 5.27 0.31 2.8e-7 Subjective well-being; CESC cis rs2635047 0.747 rs9956387 chr18:44773382 A/T cg24371990 chr18:44770781 NA 0.39 6.33 0.36 1.07e-9 Educational attainment; CESC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg22800045 chr5:56110881 MAP3K1 0.82 9.94 0.52 5.44e-20 Initial pursuit acceleration; CESC cis rs1372520 0.532 rs2583972 chr4:90747411 T/G cg15133208 chr4:90757351 SNCA -0.39 -5.25 -0.31 3.09e-7 Neuroticism; CESC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg09491104 chr22:46646882 C22orf40 -0.5 -5.93 -0.34 9.22e-9 LDL cholesterol;Cholesterol, total; CESC cis rs7336332 0.511 rs7998978 chr13:27999457 T/C cg01674679 chr13:27998804 GTF3A -0.59 -5.98 -0.34 7.12e-9 Weight; CESC cis rs12142240 0.698 rs72886911 chr1:46814352 G/A cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs7408868 1.000 rs10406754 chr19:15274201 T/A cg14696996 chr19:15285081 NOTCH3 1.11 11.47 0.58 5.57e-25 Pulse pressure; CESC cis rs7179456 0.545 rs605928 chr15:59046163 C/G cg05156742 chr15:59063176 FAM63B 0.57 7.38 0.41 2.09e-12 Asperger disorder; CESC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg01416388 chr22:39784598 NA -0.57 -6.93 -0.39 3.19e-11 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg05368731 chr17:41323189 NBR1 0.79 11.2 0.57 4.19e-24 Menopause (age at onset); CESC cis rs6537837 1.000 rs3768486 chr1:110123971 A/G cg05049280 chr1:110155535 GNAT2 0.39 5.55 0.32 6.86e-8 Major depressive disorder; CESC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 12.2 0.6 1.84e-27 Platelet count; CESC cis rs11098499 0.954 rs10006877 chr4:120242793 C/T cg09307838 chr4:120376055 NA 0.91 12.62 0.61 6.43e-29 Corneal astigmatism; CESC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.53 -0.32 7.81e-8 Huntington's disease progression; CESC cis rs7542091 0.704 rs7550330 chr1:210044587 G/A cg23283495 chr1:209979779 IRF6 0.35 5.8 0.34 1.84e-8 Monobrow; CESC cis rs3741151 0.773 rs7115055 chr11:73227827 T/C cg17517138 chr11:73019481 ARHGEF17 1.0 7.33 0.41 2.76e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs9905704 0.718 rs758377 chr17:56607124 T/C cg12560992 chr17:57184187 TRIM37 -0.63 -5.99 -0.35 6.89e-9 Testicular germ cell tumor; CESC cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg13628971 chr7:2884303 GNA12 0.45 5.93 0.34 9.59e-9 Height; CESC cis rs9394438 0.628 rs4714080 chr6:37544618 A/G cg00985040 chr6:37553208 NA 0.39 6.71 0.38 1.16e-10 IgG glycosylation; CESC cis rs9287719 0.601 rs12996735 chr2:10716716 C/A cg00105475 chr2:10696890 NA 0.4 5.4 0.32 1.46e-7 Prostate cancer; CESC cis rs6504663 0.558 rs7627 chr17:48552154 G/C cg03168497 chr17:48586147 MYCBPAP 0.47 5.62 0.33 4.72e-8 Visceral fat; CESC cis rs2832191 0.935 rs11910475 chr21:30519702 T/C cg24692254 chr21:30365293 RNF160 -0.72 -10.69 -0.55 2.14e-22 Dental caries; CESC cis rs2742417 0.603 rs2673055 chr3:45772772 G/A cg04837898 chr3:45731254 SACM1L -0.47 -6.17 -0.35 2.54e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs919433 0.926 rs787997 chr2:198216271 A/G cg20885578 chr2:198174922 NA 0.39 5.33 0.31 2.09e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs71277158 0.688 rs7615039 chr3:169806170 G/A cg04067573 chr3:169899625 PHC3 0.67 6.71 0.38 1.17e-10 Prostate cancer; CESC cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.33 5.05 0.3 8.37e-7 Height;Educational attainment;Head circumference (infant); CESC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg06221963 chr1:154839813 KCNN3 -0.66 -11.27 -0.57 2.42e-24 Prostate cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06867543 chr15:77271730 NA 0.49 6.38 0.36 7.95e-10 Ulcerative colitis; CESC cis rs4888262 0.526 rs13330282 chr16:74572373 C/T cg01733217 chr16:74700730 RFWD3 0.81 11.33 0.57 1.58e-24 Testicular germ cell tumor; CESC trans rs11098499 0.826 rs12511640 chr4:120251248 T/C cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs9303401 0.592 rs12936771 chr17:56725052 T/C cg10487724 chr17:56770010 TEX14;RAD51C 1.04 13.0 0.62 3.27e-30 Cognitive test performance; CESC cis rs2072732 0.687 rs10489588 chr1:2951834 C/T cg03976712 chr1:2946727 NA 0.33 5.58 0.32 5.96e-8 Plateletcrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03522216 chr5:32174578 GOLPH3 0.56 6.07 0.35 4.46e-9 Gut microbiome composition (summer); CESC cis rs539096 0.500 rs2367804 chr1:44314266 C/T cg12908607 chr1:44402522 ARTN -0.49 -7.38 -0.41 1.98e-12 Intelligence (multi-trait analysis); CESC cis rs12477438 0.501 rs13000731 chr2:99795231 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.75 12.51 0.61 1.6e-28 Chronic sinus infection; CESC cis rs7246657 0.943 rs8109038 chr19:38015709 A/G cg23950597 chr19:37808831 NA 0.57 5.94 0.34 9.05e-9 Coronary artery calcification; CESC cis rs897984 0.542 rs3751855 chr16:31091209 T/C cg02466173 chr16:30829666 NA -0.4 -6.88 -0.39 4.38e-11 Dementia with Lewy bodies; CESC cis rs365132 1.000 rs353464 chr5:176403023 A/G cg16309518 chr5:176445507 NA -0.39 -5.76 -0.33 2.31e-8 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.25 0.31 3.2e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg11764359 chr7:65958608 NA 0.66 8.18 0.45 1.16e-14 Aortic root size; CESC cis rs909674 0.818 rs8136980 chr22:39844574 G/A cg01416388 chr22:39784598 NA -0.58 -7.04 -0.4 1.67e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1506636 1.000 rs2259457 chr7:123424350 A/G cg03229431 chr7:123269106 ASB15 0.49 6.54 0.37 3.11e-10 Plateletcrit;Platelet count; CESC cis rs7267979 1.000 rs6050564 chr20:25344231 G/A cg08601574 chr20:25228251 PYGB -0.38 -5.46 -0.32 1.12e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg08736216 chr1:53307985 ZYG11A -0.42 -7.02 -0.4 1.86e-11 Monocyte count; CESC cis rs858239 0.600 rs13438188 chr7:23144197 C/T cg23682824 chr7:23144976 KLHL7 -0.51 -6.95 -0.39 2.84e-11 Cerebrospinal fluid biomarker levels; CESC cis rs9457247 1.000 rs385113 chr6:167403971 A/G cg25258033 chr6:167368657 RNASET2 0.39 5.88 0.34 1.26e-8 Crohn's disease; CESC cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg01546378 chr2:38892901 GALM -0.52 -7.04 -0.4 1.68e-11 5-HTT brain serotonin transporter levels; CESC cis rs9787249 0.957 rs12086750 chr1:40210468 G/C cg19912559 chr1:40204330 PPIE 0.43 6.57 0.37 2.63e-10 Blood protein levels; CESC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg05754148 chr16:3507555 NAT15 0.57 8.2 0.45 1.02e-14 Tuberculosis; CESC cis rs11792861 0.926 rs56899598 chr9:111867271 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 5.17 0.3 4.6e-7 Menarche (age at onset); CESC cis rs710865 0.541 rs12567768 chr1:19568603 T/A cg13387374 chr1:19411106 UBR4 0.45 5.5 0.32 9.11e-8 Brain structure; CESC cis rs1005277 0.522 rs11011343 chr10:38002698 A/G cg25517755 chr10:38738941 LOC399744 -0.39 -5.06 -0.3 7.79e-7 Extrinsic epigenetic age acceleration; CESC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg15921436 chr17:44337874 NA -0.48 -6.06 -0.35 4.62e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4927850 0.752 rs7618864 chr3:195749561 G/A cg01181863 chr3:195395398 SDHAP2 -0.55 -6.59 -0.38 2.33e-10 Pancreatic cancer; CESC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg05368731 chr17:41323189 NBR1 0.8 10.6 0.55 3.93e-22 Menopause (age at onset); CESC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg18402987 chr7:1209562 NA 0.59 7.0 0.4 2.06e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg26335602 chr6:28129616 ZNF389 0.53 6.75 0.38 9.35e-11 Depression; CESC cis rs698833 0.852 rs698761 chr2:44547574 A/G cg04920474 chr2:44395004 PPM1B -0.37 -5.09 -0.3 6.77e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg18099408 chr3:52552593 STAB1 -0.32 -5.43 -0.32 1.28e-7 Electroencephalogram traits; CESC cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg22875332 chr1:76189707 ACADM 0.59 5.73 0.33 2.78e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs72772090 0.539 rs56213813 chr5:96112284 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.05 -0.3 8.29e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg02574844 chr11:5959923 NA -0.42 -5.32 -0.31 2.18e-7 DNA methylation (variation); CESC cis rs11997175 0.766 rs7387133 chr8:33727045 C/G ch.8.33884649F chr8:33765107 NA -0.44 -5.83 -0.34 1.64e-8 Body mass index; CESC cis rs748404 0.586 rs2584700 chr15:43685332 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.62 7.8 0.43 1.4e-13 Lung cancer; CESC cis rs7000551 0.675 rs2469758 chr8:22363032 C/T cg12081754 chr8:22256438 SLC39A14 0.41 5.42 0.32 1.36e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs1904096 0.506 rs2632412 chr4:95149319 A/C cg11021082 chr4:95130006 SMARCAD1 0.65 9.62 0.51 5.54e-19 Type 2 diabetes; CESC trans rs11098499 0.604 rs2389882 chr4:120566733 A/C cg25214090 chr10:38739885 LOC399744 0.6 8.01 0.44 3.56e-14 Corneal astigmatism; CESC cis rs9291683 0.588 rs17247314 chr4:10004743 C/G cg02734326 chr4:10020555 SLC2A9 0.45 6.46 0.37 4.94e-10 Bone mineral density; CESC cis rs17376456 0.877 rs10213956 chr5:93460839 C/T cg21475434 chr5:93447410 FAM172A 0.85 7.6 0.42 5.01e-13 Diabetic retinopathy; CESC cis rs9611565 0.607 rs132792 chr22:42062822 C/T cg06481639 chr22:41940642 POLR3H 0.47 5.53 0.32 7.78e-8 Vitiligo; CESC cis rs10789491 1.000 rs7516616 chr1:47186274 A/G cg15501359 chr1:47185051 KIAA0494 -0.78 -8.07 -0.44 2.45e-14 Response to hepatitis C treatment; CESC cis rs1878931 0.580 rs7194596 chr16:3404408 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.97 14.77 0.67 1.96e-36 Body mass index (adult); CESC cis rs9291683 0.507 rs3775940 chr4:10025163 A/T cg00071950 chr4:10020882 SLC2A9 0.8 13.98 0.65 1.25e-33 Bone mineral density; CESC cis rs6543140 0.964 rs4851592 chr2:103087641 C/T cg04239558 chr2:103089729 SLC9A4 0.47 6.23 0.36 1.83e-9 Blood protein levels; CESC cis rs453301 0.507 rs2929306 chr8:9084909 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -6.6 -0.38 2.29e-10 Joint mobility (Beighton score); CESC cis rs400736 0.740 rs225129 chr1:8094164 T/A cg25007680 chr1:8021821 PARK7 0.71 9.96 0.52 4.56e-20 Response to antidepressants and depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12957096 chr22:41777779 TEF 0.62 6.98 0.39 2.31e-11 Gut microbiome composition (summer); CESC cis rs870825 0.616 rs4264873 chr4:185624336 C/T cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs7089973 0.624 rs10885614 chr10:116609098 C/T cg03647239 chr10:116582469 FAM160B1 0.43 5.35 0.31 1.94e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs61931739 0.500 rs3924705 chr12:34557825 A/T cg26384229 chr12:38710491 ALG10B 0.53 7.41 0.41 1.74e-12 Morning vs. evening chronotype; CESC cis rs8002861 0.905 rs12874535 chr13:44433565 A/G cg14210620 chr13:44453864 C13orf31;CCDC122 -0.42 -5.35 -0.31 1.9e-7 Leprosy; CESC cis rs11785400 0.793 rs2280879 chr8:143722228 T/C cg10596483 chr8:143751796 JRK 0.4 5.14 0.3 5.32e-7 Schizophrenia; CESC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg10664184 chr19:17420304 DDA1 0.44 5.18 0.3 4.35e-7 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22779765 chr14:103369786 TRAF3 -0.58 -6.34 -0.36 9.73e-10 Gut microbiome composition (summer); CESC cis rs9300255 0.602 rs2682434 chr12:123694724 C/T cg05973401 chr12:123451056 ABCB9 0.49 5.63 0.33 4.63e-8 Neutrophil percentage of white cells; CESC cis rs1008375 1.000 rs28497813 chr4:17685503 A/G cg02297831 chr4:17616191 MED28 0.42 5.44 0.32 1.2e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3540 0.513 rs2601154 chr15:90894284 T/C cg10434728 chr15:90938212 IQGAP1 0.41 7.18 0.4 7.06e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs3820068 0.705 rs4646103 chr1:15819827 T/A cg17385448 chr1:15911702 AGMAT 0.39 6.09 0.35 3.91e-9 Systolic blood pressure; CESC cis rs1642645 0.831 rs2886564 chr1:42496924 G/A cg16685388 chr1:42384056 HIVEP3 0.37 5.61 0.33 5.2e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs1355223 0.902 rs1539251 chr11:34742772 A/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.44 -0.37 5.45e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs6987853 0.563 rs7004796 chr8:42450170 T/G cg09913449 chr8:42400586 C8orf40 0.34 5.48 0.32 1.01e-7 Mean corpuscular hemoglobin concentration; CESC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg06505273 chr16:24850292 NA 0.53 6.51 0.37 3.7e-10 Intelligence (multi-trait analysis); CESC cis rs6088580 0.634 rs6059867 chr20:33078103 C/T cg24642439 chr20:33292090 TP53INP2 0.54 7.04 0.4 1.68e-11 Glomerular filtration rate (creatinine); CESC cis rs11690935 0.921 rs4668414 chr2:172704291 A/C cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.15 -0.66 2.96e-34 Schizophrenia; CESC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg03188948 chr7:1209495 NA 0.72 6.91 0.39 3.61e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg23462726 chr11:62437636 C11orf83;C11orf48 -0.45 -5.86 -0.34 1.39e-8 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25345767 chr1:226070210 TMEM63A 0.55 6.38 0.36 7.97e-10 Gut microbiome composition (summer); CESC trans rs1814175 0.647 rs28456013 chr11:50047629 T/C cg15704280 chr7:45808275 SEPT13 -0.85 -11.66 -0.58 1.2e-25 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23260799 chr11:451101 PTDSS2 -0.44 -6.22 -0.36 1.97e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03770877 chr3:73046015 PPP4R2 0.48 6.1 0.35 3.83e-9 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs35046236 chr7:65408613 T/C cg13147721 chr7:65941812 NA -0.85 -8.1 -0.45 2e-14 Diabetic kidney disease; CESC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.95 0.39 2.86e-11 Electroencephalogram traits; CESC cis rs477692 1.000 rs548390 chr10:131417427 G/A cg05714579 chr10:131428358 MGMT 0.48 6.46 0.37 5.02e-10 Response to temozolomide; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg10047026 chr17:4613992 ARRB2 -0.41 -6.18 -0.35 2.43e-9 Breast cancer; CESC cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg17724175 chr1:150552817 MCL1 -0.31 -5.15 -0.3 5.19e-7 Tonsillectomy; CESC cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg10523679 chr1:76189770 ACADM 0.54 6.13 0.35 3.18e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.39 0.61 4.17e-28 Alzheimer's disease; CESC cis rs12142240 0.659 rs72677591 chr1:46818219 T/G cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00093900 chr1:204381012 PPP1R15B -0.54 -6.5 -0.37 3.92e-10 Gut microbiome composition (summer); CESC cis rs2737618 0.674 rs2260033 chr1:200086074 G/A cg21825944 chr1:200113062 NR5A2 -0.45 -6.77 -0.38 8.12e-11 Uric acid levels; CESC cis rs644799 0.525 rs3016206 chr11:95536724 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.75 10.51 0.54 8.07e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14777817 chr13:80055594 NDFIP2 -0.42 -6.02 -0.35 5.88e-9 Fibrinogen levels; CESC cis rs483180 0.512 rs594400 chr1:120214275 G/T cg19096424 chr1:120255104 PHGDH -0.43 -5.21 -0.31 3.72e-7 Macular telangiectasia type 2; CESC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg17724175 chr1:150552817 MCL1 0.34 5.26 0.31 2.91e-7 Melanoma; CESC cis rs8044868 0.586 rs12917999 chr16:72089451 T/C cg16558253 chr16:72132732 DHX38 -0.41 -6.49 -0.37 4.12e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs9393777 0.623 rs7756567 chr6:26481642 T/G cg12826209 chr6:26865740 GUSBL1 0.65 6.85 0.39 5.16e-11 Intelligence (multi-trait analysis); CESC cis rs748404 0.690 rs1079309 chr15:43783164 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.5 7.74 0.43 2.06e-13 Lung cancer; CESC cis rs11945232 1.000 rs28630962 chr4:88336386 C/T cg23841344 chr4:88312519 HSD17B11 -0.64 -7.97 -0.44 4.78e-14 Intelligence (multi-trait analysis); CESC cis rs6963495 0.745 rs2392749 chr7:105182605 A/G cg13798780 chr7:105162888 PUS7 0.63 7.31 0.41 3.16e-12 Bipolar disorder (body mass index interaction); CESC cis rs7072216 0.763 rs12763326 chr10:100167396 A/G cg26618903 chr10:100175079 PYROXD2 0.37 5.69 0.33 3.28e-8 Metabolite levels; CESC cis rs868036 0.609 rs3784707 chr15:68043878 A/C cg08079166 chr15:68083412 MAP2K5 0.4 5.32 0.31 2.25e-7 Restless legs syndrome; CESC cis rs2933343 0.672 rs1872545 chr3:128645039 G/C cg25356066 chr3:128598488 ACAD9 0.6 8.4 0.46 2.72e-15 IgG glycosylation; CESC trans rs10780944 0.620 rs17535600 chr9:73130529 G/A cg06462780 chr16:1843741 IGFALS 0.43 6.08 0.35 4.11e-9 Pubertal anthropometrics; CESC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg22535103 chr8:58192502 C8orf71 -0.84 -9.44 -0.5 2.04e-18 Developmental language disorder (linguistic errors); CESC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg24531977 chr5:56204891 C5orf35 -0.87 -10.92 -0.56 3.64e-23 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03503634 chr11:36531973 TRAF6 0.56 6.18 0.35 2.37e-9 Gut microbiome composition (summer); CESC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg19346786 chr7:2764209 NA 0.45 6.65 0.38 1.68e-10 Height; CESC cis rs12618769 0.597 rs3754886 chr2:99107677 A/G cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs2243480 1.000 rs906134 chr7:65444288 G/C cg13147721 chr7:65941812 NA -0.9 -8.65 -0.47 4.98e-16 Diabetic kidney disease; CESC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg04166393 chr7:2884313 GNA12 0.59 8.08 0.44 2.29e-14 Height; CESC cis rs4664304 0.966 rs925407 chr2:160767502 A/C cg03641300 chr2:160917029 PLA2R1 -0.48 -6.88 -0.39 4.42e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs7516138 1.000 rs4240895 chr1:9713386 C/T cg26573321 chr1:9711663 PIK3CD 0.61 9.33 0.5 4.49e-18 Monocyte count; CESC cis rs12618769 0.597 rs3769719 chr2:99124404 T/C cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC cis rs3105593 1.000 rs3109878 chr15:50836243 T/G cg08437265 chr15:50716283 USP8 0.44 5.69 0.33 3.44e-8 QT interval; CESC cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg27129171 chr3:47204927 SETD2 0.68 9.96 0.52 4.81e-20 Colorectal cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11066750 chr2:120125096 C2orf76;DBI -0.44 -6.01 -0.35 5.96e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2820292 1.000 rs2644128 chr1:201793440 C/G cg11586189 chr1:201857591 SHISA4 -0.31 -5.35 -0.31 1.86e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs2797160 1.000 rs926853 chr6:126021435 A/T cg05901451 chr6:126070800 HEY2 0.45 6.46 0.37 5.01e-10 Endometrial cancer; CESC cis rs12995491 0.933 rs12995212 chr2:88527184 C/T cg04511125 chr2:88470314 THNSL2 -0.49 -6.98 -0.39 2.43e-11 Response to metformin (IC50); CESC cis rs9399135 0.967 rs2183709 chr6:135377091 C/T cg22676075 chr6:135203613 NA 0.52 7.29 0.41 3.61e-12 Red blood cell count; CESC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 12.35 0.6 5.74e-28 Platelet count; CESC cis rs4423214 0.610 rs12789253 chr11:71125765 G/A cg05163923 chr11:71159392 DHCR7 0.6 7.94 0.44 5.72e-14 Vitamin D levels; CESC cis rs1595825 0.838 rs58576043 chr2:198524149 C/T cg10820045 chr2:198174542 NA 0.41 5.21 0.3 3.79e-7 Ulcerative colitis; CESC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg12564285 chr5:131593104 PDLIM4 0.4 6.09 0.35 3.99e-9 Breast cancer; CESC cis rs6500602 0.727 rs7193136 chr16:4580034 C/T cg08645402 chr16:4508243 NA 0.5 7.97 0.44 4.66e-14 Schizophrenia; CESC cis rs4589502 0.800 rs1498499 chr15:67202620 C/T cg12317470 chr15:67143691 NA -0.68 -7.97 -0.44 4.68e-14 Lung cancer (smoking interaction); CESC trans rs11039798 0.920 rs11500574 chr11:48713986 A/T cg15704280 chr7:45808275 SEPT13 0.7 6.31 0.36 1.15e-9 Axial length; CESC trans rs3808502 0.574 rs4841559 chr8:11416885 C/T cg15556689 chr8:8085844 FLJ10661 -0.57 -6.81 -0.39 6.39e-11 Neuroticism; CESC cis rs6032067 0.777 rs56191952 chr20:43802487 A/G cg10761708 chr20:43804764 PI3 0.56 6.65 0.38 1.7e-10 Blood protein levels; CESC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.9 -12.56 -0.61 1.07e-28 Alzheimer's disease; CESC cis rs4253772 0.550 rs9615347 chr22:46728153 A/G cg18190219 chr22:46762943 CELSR1 -0.59 -5.25 -0.31 3.06e-7 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04031383 chr16:84088007 MBTPS1 -0.56 -6.23 -0.36 1.81e-9 Gut microbiome composition (summer); CESC cis rs12780046 0.505 rs10883307 chr10:101038249 G/A cg27143070 chr10:101087766 CNNM1 0.36 5.26 0.31 3.03e-7 Non-glioblastoma glioma; CESC cis rs7590720 1.000 rs1991533 chr2:216908910 T/C cg12620499 chr2:216877984 MREG 0.9 12.13 0.6 3.27e-27 Alcohol dependence; CESC cis rs1505368 0.781 rs10197836 chr2:213274278 T/C cg16329650 chr2:213403929 ERBB4 0.38 5.24 0.31 3.28e-7 Symmetrical dimethylarginine levels; CESC cis rs4718428 0.607 rs66954441 chr7:66369209 T/C cg12165864 chr7:66369176 NA -0.67 -7.8 -0.43 1.41e-13 Corneal structure; CESC cis rs6701037 1.000 rs11580331 chr1:175123288 T/C cg00321850 chr1:175162397 KIAA0040 -0.42 -5.86 -0.34 1.37e-8 Alcohol dependence; CESC trans rs116095464 0.558 rs13356367 chr5:242395 C/T cg00938859 chr5:1591904 SDHAP3 0.64 6.98 0.39 2.36e-11 Breast cancer; CESC cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg15506890 chr2:3487001 NA 0.47 5.78 0.33 2.07e-8 Neurofibrillary tangles; CESC cis rs7178572 0.568 rs4886515 chr15:77686886 G/A cg22256960 chr15:77711686 NA -0.54 -6.95 -0.39 2.9e-11 Type 2 diabetes; CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -6.62 -0.38 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6728642 0.901 rs10179966 chr2:97845100 C/T cg26665480 chr2:98280029 ACTR1B -0.74 -7.26 -0.41 4.32e-12 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs919433 0.889 rs6711624 chr2:198207607 C/G cg03934865 chr2:198174659 NA -0.46 -6.59 -0.38 2.34e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9300255 0.639 rs941306 chr12:123715113 C/T cg19016782 chr12:123741754 C12orf65 -0.5 -7.08 -0.4 1.33e-11 Neutrophil percentage of white cells; CESC cis rs7586879 0.687 rs11892869 chr2:25096692 A/T cg01884057 chr2:25150051 NA 0.38 7.4 0.41 1.85e-12 Body mass index; CESC cis rs2228479 0.850 rs11649162 chr16:89807131 C/A cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.89e-7 Skin colour saturation; CESC cis rs10779751 1.000 rs2300093 chr1:11266392 G/C cg08854313 chr1:11322531 MTOR 0.91 14.23 0.66 1.56e-34 Body mass index; CESC cis rs113835537 0.529 rs61561111 chr11:66275923 T/C cg22134325 chr11:66188745 NPAS4 0.36 5.64 0.33 4.35e-8 Airway imaging phenotypes; CESC cis rs7851660 0.839 rs10113884 chr9:100624622 C/T cg13688889 chr9:100608707 NA -0.64 -8.89 -0.48 9.61e-17 Strep throat; CESC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg04511125 chr2:88470314 THNSL2 0.69 6.76 0.38 8.71e-11 Plasma clusterin levels; CESC cis rs7824557 0.564 rs11781637 chr8:11214972 C/T cg21775007 chr8:11205619 TDH -0.51 -7.85 -0.43 1.04e-13 Retinal vascular caliber; CESC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg18876405 chr7:65276391 NA -0.45 -6.21 -0.36 2e-9 Aortic root size; CESC cis rs2243480 1.000 rs35283677 chr7:65359233 C/T cg18252515 chr7:66147081 NA -1.18 -11.4 -0.57 9.2e-25 Diabetic kidney disease; CESC cis rs367943 0.637 rs6859521 chr5:113007423 C/T cg12552261 chr5:112820674 MCC 0.45 5.33 0.31 2.05e-7 Type 2 diabetes; CESC cis rs9470366 0.509 rs4714001 chr6:36638175 G/A cg08179530 chr6:36648295 CDKN1A -0.63 -9.36 -0.5 3.54e-18 QRS duration; CESC cis rs9611565 0.559 rs6002408 chr22:41967870 C/T cg17376030 chr22:41985996 PMM1 0.52 5.58 0.32 6.06e-8 Vitiligo; CESC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg08736216 chr1:53307985 ZYG11A -0.44 -7.4 -0.41 1.77e-12 Monocyte count; CESC cis rs4423214 0.592 rs10898191 chr11:71194601 G/A cg05163923 chr11:71159392 DHCR7 -0.59 -6.16 -0.35 2.73e-9 Vitamin D levels; CESC cis rs72772090 0.539 rs11747148 chr5:96112863 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.05 -0.3 8.29e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.85 0.34 1.47e-8 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05705089 chr20:42839217 C20orf111 0.63 7.16 0.4 8.12e-12 Gut microbiome composition (summer); CESC cis rs9326248 0.590 rs2542063 chr11:116684767 C/T cg16524733 chr11:117070046 TAGLN 0.28 5.18 0.3 4.39e-7 Blood protein levels; CESC cis rs854765 0.547 rs4365348 chr17:17912548 C/T cg16928487 chr17:17741425 SREBF1 -0.58 -10.31 -0.53 3.65e-21 Total body bone mineral density; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg26994227 chr5:130971071 RAPGEF6 0.53 6.4 0.37 7.1e-10 Psoriatic arthritis; CESC cis rs73195822 0.506 rs61440260 chr12:111142855 G/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.65 0.33 4.05e-8 Itch intensity from mosquito bite; CESC cis rs6987853 0.966 rs1901282 chr8:42392942 C/G cg09913449 chr8:42400586 C8orf40 0.39 6.13 0.35 3.15e-9 Mean corpuscular hemoglobin concentration; CESC cis rs6665290 0.904 rs10916075 chr1:227184074 G/A cg10327440 chr1:227177885 CDC42BPA -1.2 -31.28 -0.89 6.16e-91 Myeloid white cell count; CESC cis rs6502050 0.835 rs4789666 chr17:80162276 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.15 -0.3 4.98e-7 Life satisfaction; CESC cis rs6032067 1.000 rs6032042 chr20:43815949 T/C cg11264863 chr20:43835661 SEMG1 0.49 5.29 0.31 2.5e-7 Blood protein levels; CESC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg13607699 chr17:42295918 UBTF 0.63 8.35 0.46 3.84e-15 Total body bone mineral density; CESC cis rs2228479 0.867 rs62052187 chr16:89973071 G/A cg00800038 chr16:89945340 TCF25 -0.75 -7.11 -0.4 1.1e-11 Skin colour saturation; CESC cis rs9660992 0.710 rs1668864 chr1:205248799 T/C cg21643547 chr1:205240462 TMCC2 -0.46 -6.16 -0.35 2.67e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs11785693 0.862 rs11774842 chr8:4979769 A/C cg26367366 chr8:4980734 NA 0.81 7.32 0.41 2.88e-12 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg18765753 chr7:1198926 ZFAND2A -0.45 -6.53 -0.37 3.27e-10 Longevity;Endometriosis; CESC trans rs10463316 0.894 rs6579862 chr5:150761717 T/G cg24389359 chr12:111284228 CCDC63 -0.34 -6.08 -0.35 4.1e-9 Metabolite levels (Pyroglutamine); CESC cis rs4423214 0.524 rs4944046 chr11:71123794 C/G cg05163923 chr11:71159392 DHCR7 0.43 5.46 0.32 1.11e-7 Vitamin D levels; CESC cis rs1005224 0.927 rs1981899 chr14:76175594 G/A cg25116370 chr14:76127843 TTLL5;C14orf1 -0.43 -5.83 -0.34 1.57e-8 Large artery stroke; CESC cis rs6540559 0.546 rs735694 chr1:210034029 T/C cg22029157 chr1:209979665 IRF6 0.72 7.16 0.4 8.04e-12 Cleft lip with or without cleft palate; CESC cis rs11997175 0.574 rs4236733 chr8:33655582 G/A ch.8.33884649F chr8:33765107 NA 0.66 8.38 0.46 3.14e-15 Body mass index; CESC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.55 0.46 9.94e-16 Electroencephalogram traits; CESC cis rs9660180 0.967 rs61422524 chr1:1767565 C/A cg20999797 chr1:1681921 NA 0.26 5.13 0.3 5.64e-7 Body mass index; CESC cis rs763121 0.819 rs5757160 chr22:38989646 T/C cg06022373 chr22:39101656 GTPBP1 0.94 17.17 0.73 5.98e-45 Menopause (age at onset); CESC cis rs739401 0.595 rs2237903 chr11:2967901 C/T cg08508325 chr11:3079039 CARS -0.46 -7.9 -0.44 7.55e-14 Longevity; CESC cis rs7819412 0.740 rs11250119 chr8:11037034 C/T cg14752069 chr8:11977206 FAM66D -0.32 -5.41 -0.32 1.4e-7 Triglycerides; CESC cis rs1697139 0.583 rs1428474 chr5:66544015 C/A cg11553311 chr5:66541588 NA 0.38 5.25 0.31 3.1e-7 Breast cancer; CESC cis rs11514810 1.000 rs4076699 chr7:1435521 C/T cg24899294 chr7:1481343 MICALL2 -0.67 -5.54 -0.32 7.25e-8 Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder; CESC cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.13 0.35 3.25e-9 Hip circumference adjusted for BMI; CESC cis rs6062302 0.522 rs2297428 chr20:62221766 C/T cg06363034 chr20:62225388 GMEB2 -0.52 -6.63 -0.38 1.91e-10 Glioblastoma; CESC cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg05343316 chr1:45956843 TESK2 -0.5 -6.52 -0.37 3.59e-10 High light scatter reticulocyte count; CESC cis rs7647973 1.000 rs12583 chr3:49571462 G/T cg02487422 chr3:49467188 NICN1 -0.42 -5.39 -0.31 1.53e-7 Menarche (age at onset); CESC cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg02297831 chr4:17616191 MED28 -0.49 -5.8 -0.34 1.89e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs854765 0.583 rs8070722 chr17:17813562 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.19 0.45 1.1e-14 Total body bone mineral density; CESC cis rs10744422 1.000 rs936083 chr12:123338964 A/G cg25930673 chr12:123319894 HIP1R -0.76 -5.88 -0.34 1.26e-8 Schizophrenia; CESC cis rs7666738 0.546 rs11097591 chr4:98910173 G/A cg05340658 chr4:99064831 C4orf37 0.54 6.47 0.37 4.73e-10 Colonoscopy-negative controls vs population controls; CESC cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.65 -7.96 -0.44 5.17e-14 Multiple sclerosis; CESC cis rs76917914 0.780 rs2417727 chr9:100846475 T/C cg03040243 chr9:100819229 NANS 0.47 5.19 0.3 4.27e-7 Immature fraction of reticulocytes; CESC cis rs3862260 0.509 rs10754416 chr1:120163531 A/G cg16322792 chr1:120165303 ZNF697 0.58 11.03 0.56 1.53e-23 Systemic lupus erythematosus; CESC cis rs2228479 0.850 rs11648689 chr16:89806732 G/A cg14709524 chr16:89940631 TCF25 0.93 6.87 0.39 4.68e-11 Skin colour saturation; CESC cis rs4076764 0.801 rs4571944 chr1:163367975 T/C cg24596788 chr1:163392923 NA -0.42 -5.94 -0.34 8.9e-9 Motion sickness; CESC cis rs7953249 0.502 rs1169294 chr12:121426594 G/A cg25281562 chr12:121454272 C12orf43 0.57 7.18 0.4 7.24e-12 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg19445457 chr11:5799446 OR52N5 -0.38 -5.06 -0.3 8.01e-7 DNA methylation (variation); CESC trans rs12310956 0.532 rs11052933 chr12:33969881 G/A cg26384229 chr12:38710491 ALG10B 0.58 8.12 0.45 1.8e-14 Morning vs. evening chronotype; CESC cis rs10416265 0.502 rs7245411 chr19:33543029 A/T cg03563238 chr19:33554763 RHPN2 -0.3 -5.2 -0.3 4.07e-7 Bone properties (heel); CESC cis rs34779708 0.897 rs34481177 chr10:35380913 C/T cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs8050907 0.744 rs55810554 chr16:4524392 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs6500602 0.627 rs2270363 chr16:4526292 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.42 5.77 0.33 2.22e-8 Schizophrenia; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg10541813 chr2:85839361 C2orf68 -0.41 -6.53 -0.37 3.36e-10 Vertical cup-disc ratio; CESC cis rs4919087 0.651 rs12240590 chr10:99072066 C/G cg25902810 chr10:99078978 FRAT1 -0.48 -5.43 -0.32 1.29e-7 Monocyte count; CESC cis rs2292884 0.505 rs11889660 chr2:238438395 C/T cg14458575 chr2:238380390 NA 0.6 5.91 0.34 1.07e-8 Prostate cancer; CESC trans rs61931739 0.500 rs73103774 chr12:34482279 C/T cg13010199 chr12:38710504 ALG10B 0.5 6.52 0.37 3.54e-10 Morning vs. evening chronotype; CESC cis rs7824557 0.767 rs7003241 chr8:11169075 A/G cg21775007 chr8:11205619 TDH 0.49 7.08 0.4 1.28e-11 Retinal vascular caliber; CESC cis rs9217 0.513 rs7216801 chr17:7386811 A/T cg02795151 chr17:7402630 POLR2A 0.55 5.86 0.34 1.41e-8 Height; CESC cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg17211192 chr8:82754475 SNX16 0.53 6.72 0.38 1.14e-10 Diastolic blood pressure; CESC cis rs6088590 0.561 rs6059934 chr20:33178324 G/T cg24642439 chr20:33292090 TP53INP2 0.61 8.14 0.45 1.56e-14 Coronary artery disease; CESC cis rs2455799 0.573 rs2174172 chr3:15768579 C/A cg16303742 chr3:15540471 COLQ -0.39 -6.19 -0.36 2.32e-9 Mean platelet volume; CESC cis rs921968 0.565 rs3821035 chr2:219620223 T/G cg02176678 chr2:219576539 TTLL4 -0.44 -7.67 -0.43 3.29e-13 Mean corpuscular hemoglobin concentration; CESC cis rs7659604 1.000 rs7689714 chr4:122665943 T/A cg19671926 chr4:122722719 EXOSC9 -0.49 -5.92 -0.34 9.92e-9 Type 2 diabetes; CESC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg18350739 chr11:68623251 NA -0.46 -7.02 -0.4 1.88e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1865760 0.566 rs9295686 chr6:26081983 G/C cg17691542 chr6:26056736 HIST1H1C 0.42 5.57 0.32 6.13e-8 Height; CESC cis rs9660992 0.624 rs72745217 chr1:205261482 C/G cg00857998 chr1:205179979 DSTYK 0.49 5.51 0.32 8.52e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs765787 0.530 rs28414644 chr15:45536721 G/C cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg27057461 chr7:158136379 PTPRN2 -0.33 -5.17 -0.3 4.6e-7 Calcium levels; CESC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.18 0.4 6.92e-12 Depression; CESC cis rs10949834 0.504 rs12539781 chr7:73568425 C/T cg07137043 chr7:73588983 EIF4H -0.63 -6.98 -0.39 2.36e-11 Verbal memory performance (residualized delayed recall change); CESC cis rs523522 0.962 rs4767912 chr12:120981202 A/G cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs7918232 0.941 rs1753415 chr10:27395102 T/C cg14442939 chr10:27389572 ANKRD26 0.68 6.47 0.37 4.78e-10 Breast cancer; CESC cis rs1062177 1.000 rs2964576 chr5:151150602 T/G cg00977110 chr5:151150581 G3BP1 0.67 7.15 0.4 8.3e-12 Preschool internalizing problems; CESC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.84 0.39 5.36e-11 Depression; CESC cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg00149659 chr3:10157352 C3orf10 0.7 8.38 0.46 3.2e-15 Alzheimer's disease; CESC cis rs4604732 0.527 rs79329288 chr1:247626513 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs1538970 0.669 rs3219476 chr1:45802670 A/C cg24296786 chr1:45957014 TESK2 0.5 6.57 0.37 2.65e-10 Platelet count; CESC cis rs72945132 0.882 rs7121012 chr11:70214421 A/T cg00319359 chr11:70116639 PPFIA1 0.72 6.89 0.39 4.01e-11 Coronary artery disease; CESC cis rs6539267 0.741 rs2279759 chr12:106694988 T/C cg00173435 chr12:106696525 TCP11L2 0.68 8.0 0.44 3.88e-14 Tourette syndrome; CESC cis rs28374715 0.528 rs28492932 chr15:41624397 G/C cg18705301 chr15:41695430 NDUFAF1 -1.05 -15.34 -0.69 1.9e-38 Ulcerative colitis; CESC cis rs10493773 0.609 rs10873716 chr1:86178347 G/T cg17807903 chr1:86174739 ZNHIT6 -0.44 -6.53 -0.37 3.43e-10 Urate levels in overweight individuals; CESC cis rs2652834 0.904 rs7175602 chr15:63367032 T/C cg05507819 chr15:63340323 TPM1 -0.67 -6.95 -0.39 2.84e-11 HDL cholesterol; CESC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.12 -0.4 9.89e-12 Total body bone mineral density; CESC cis rs7223966 0.960 rs2319990 chr17:61705397 T/C cg11494091 chr17:61959527 GH2 0.4 5.63 0.33 4.49e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6688613 0.765 rs56229522 chr1:166816108 T/A cg07049167 chr1:166818506 POGK 0.48 5.99 0.35 6.88e-9 Refractive astigmatism; CESC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.65 0.47 4.88e-16 Menopause (age at onset); CESC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg04025307 chr7:1156635 C7orf50 0.42 5.15 0.3 5.16e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2243480 1.000 rs4718317 chr7:65648901 A/G cg13147721 chr7:65941812 NA 0.92 8.72 0.47 3.02e-16 Diabetic kidney disease; CESC cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg05347473 chr6:146136440 FBXO30 0.55 7.26 0.41 4.4e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs1008375 0.618 rs13129002 chr4:17567513 A/G cg16339924 chr4:17578868 LAP3 0.6 7.28 0.41 3.84e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg13147721 chr7:65941812 NA -0.88 -8.52 -0.46 1.19e-15 Diabetic kidney disease; CESC cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg06636001 chr8:8085503 FLJ10661 0.56 6.67 0.38 1.45e-10 Mood instability; CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg23978390 chr7:1156363 C7orf50 0.55 7.54 0.42 7.57e-13 Longevity;Endometriosis; CESC cis rs3806843 0.676 rs778591 chr5:140025484 G/A cg26395211 chr5:140044315 WDR55 0.49 6.21 0.36 2.07e-9 Depressive symptoms (multi-trait analysis); CESC cis rs1008375 0.966 rs28750296 chr4:17685826 A/T cg16339924 chr4:17578868 LAP3 0.51 6.66 0.38 1.58e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9815354 0.767 rs73081335 chr3:41895177 A/G cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.84e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.06 10.39 0.54 1.98e-21 Platelet count; CESC cis rs6570726 0.818 rs437978 chr6:145809134 A/G cg05347473 chr6:146136440 FBXO30 0.51 6.71 0.38 1.16e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1059312 0.932 rs11059916 chr12:129287609 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.7 -9.54 -0.51 9.53e-19 Systemic lupus erythematosus; CESC cis rs3136441 0.892 rs898604 chr11:46917983 A/G cg25783544 chr11:47291846 MADD 0.51 5.46 0.32 1.11e-7 HDL cholesterol; CESC cis rs9303401 0.614 rs8081058 chr17:57160513 G/C cg25039879 chr17:56429692 SUPT4H1 0.5 5.29 0.31 2.58e-7 Cognitive test performance; CESC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg06028605 chr16:24865363 SLC5A11 -0.54 -8.12 -0.45 1.77e-14 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1023500 0.551 rs133371 chr22:42465574 G/A cg15557168 chr22:42548783 NA -0.45 -6.5 -0.37 3.87e-10 Schizophrenia; CESC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg26338869 chr17:61819248 STRADA -0.69 -9.06 -0.49 2.99e-17 Prudent dietary pattern; CESC cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg08847533 chr14:75593920 NEK9 -0.94 -16.69 -0.72 3.23e-43 Height; CESC cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg23711669 chr6:146136114 FBXO30 1.02 15.62 0.69 2.01e-39 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01327474 chr16:28223637 XPO6 -0.65 -7.79 -0.43 1.52e-13 Gut microbiome composition (summer); CESC cis rs7223966 1.000 rs9891018 chr17:61827856 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 6.74 0.38 9.83e-11 Hip circumference adjusted for BMI;Body mass index; CESC cis rs660498 0.507 rs2020155 chr10:27740194 C/T cg25705717 chr10:27608719 NA 0.47 5.66 0.33 3.87e-8 Asthma (childhood onset); CESC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg04317338 chr11:64019027 PLCB3 0.9 9.42 0.5 2.3e-18 Mean platelet volume; CESC cis rs7264396 0.733 rs6060515 chr20:34211779 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.51 -0.58 3.98e-25 Total cholesterol levels; CESC trans rs11165623 0.792 rs6701031 chr1:96975515 C/T cg10631902 chr5:14652156 NA -0.48 -7.0 -0.4 2.14e-11 Hip circumference;Waist circumference; CESC cis rs3818285 0.610 rs642938 chr10:111633025 A/C cg00817464 chr10:111662876 XPNPEP1 0.44 6.7 0.38 1.21e-10 Superior crus of antihelix expression; CESC cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg05340658 chr4:99064831 C4orf37 0.78 11.87 0.59 2.5e-26 Colonoscopy-negative controls vs population controls; CESC cis rs1983891 0.673 rs9369296 chr6:41570251 A/G cg20194872 chr6:41519635 FOXP4 0.43 6.09 0.35 3.86e-9 Prostate cancer; CESC trans rs61931739 0.500 rs11053272 chr12:34547020 C/G cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC cis rs8141529 0.748 rs132533 chr22:29299571 A/G cg02153584 chr22:29168773 CCDC117 -0.57 -7.19 -0.4 6.52e-12 Lymphocyte counts; CESC cis rs9467711 0.606 rs9379875 chr6:26444732 C/T cg14345882 chr6:26364793 BTN3A2 0.63 5.85 0.34 1.42e-8 Autism spectrum disorder or schizophrenia; CESC cis rs3820928 0.845 rs13415319 chr2:227878936 G/C cg05526886 chr2:227700861 RHBDD1 -0.43 -5.21 -0.3 3.85e-7 Pulmonary function; CESC cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg10556349 chr10:835070 NA 0.53 5.75 0.33 2.5e-8 Eosinophil percentage of granulocytes; CESC cis rs2051211 0.947 rs60479981 chr3:38568611 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.66 -7.44 -0.42 1.37e-12 QRS duration; CESC cis rs9549260 0.755 rs7989711 chr13:41215696 C/T cg21288729 chr13:41239152 FOXO1 0.65 8.62 0.47 6.27e-16 Red blood cell count; CESC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.04 0.49 3.47e-17 Tonsillectomy; CESC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.82e-40 Aortic root size; CESC cis rs889312 0.500 rs832580 chr5:56172646 T/C cg14703610 chr5:56206110 C5orf35 0.48 6.19 0.36 2.29e-9 Breast cancer;Breast cancer (early onset); CESC cis rs7949030 0.688 rs2849031 chr11:62365665 G/A cg13298116 chr11:62369859 EML3;MTA2 -0.62 -9.16 -0.49 1.43e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2228479 0.850 rs62056103 chr16:89942781 G/A cg06558623 chr16:89946397 TCF25 1.13 8.89 0.48 9.9900000000000006e-17 Skin colour saturation; CESC cis rs3126085 0.935 rs74129461 chr1:152285099 C/T cg03465714 chr1:152285911 FLG 0.5 5.71 0.33 2.96e-8 Atopic dermatitis; CESC cis rs506597 1.000 rs564449 chr7:100321138 G/T cg10426581 chr7:100472382 SRRT 0.61 5.1 0.3 6.36e-7 Pursuit maintenance gain in psychotic disorders; CESC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg18876405 chr7:65276391 NA 0.49 6.52 0.37 3.49e-10 Aortic root size; CESC cis rs60843830 1.000 rs62114501 chr2:231741 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.88 11.69 0.58 9.5e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs5753037 0.702 rs249398 chr22:30214704 G/C cg01021169 chr22:30184971 ASCC2 -0.47 -6.72 -0.38 1.13e-10 Type 1 diabetes; CESC cis rs3026101 0.671 rs1065482 chr17:5284719 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.89 0.34 1.18e-8 Body mass index; CESC cis rs7100689 0.646 rs6585967 chr10:82139791 A/G cg00277334 chr10:82204260 NA 0.56 7.24 0.41 4.89e-12 Post bronchodilator FEV1; CESC trans rs7615952 0.551 rs12695470 chr3:125635718 C/A cg07211511 chr3:129823064 LOC729375 -1.1 -13.63 -0.64 2.03e-32 Blood pressure (smoking interaction); CESC cis rs6546537 0.869 rs35024605 chr2:69820332 A/G cg10773587 chr2:69614142 GFPT1 -0.55 -6.78 -0.38 7.79e-11 Serum thyroid-stimulating hormone levels; CESC cis rs4595586 0.545 rs12813151 chr12:39363405 C/G cg26384229 chr12:38710491 ALG10B -0.52 -7.09 -0.4 1.19e-11 Morning vs. evening chronotype; CESC cis rs2832191 0.755 rs2832193 chr21:30493589 T/C cg24692254 chr21:30365293 RNF160 -0.79 -11.89 -0.59 2e-26 Dental caries; CESC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg18252515 chr7:66147081 NA -0.43 -5.59 -0.32 5.73e-8 Aortic root size; CESC cis rs9527 0.830 rs11191442 chr10:104643596 T/A cg04362960 chr10:104952993 NT5C2 0.44 5.18 0.3 4.38e-7 Arsenic metabolism; CESC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg03060546 chr3:49711283 APEH 0.45 5.5 0.32 9e-8 Parkinson's disease; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg11122148 chr13:45150705 TSC22D1 -0.42 -6.31 -0.36 1.13e-9 Breast cancer; CESC cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg17211192 chr8:82754475 SNX16 0.69 8.29 0.45 5.83e-15 Diastolic blood pressure; CESC cis rs6547741 0.717 rs2178197 chr2:27860551 C/T cg27432699 chr2:27873401 GPN1 0.57 8.46 0.46 1.81e-15 Oral cavity cancer; CESC cis rs2797160 0.515 rs9375409 chr6:125972798 A/G cg05901451 chr6:126070800 HEY2 -0.38 -5.27 -0.31 2.83e-7 Endometrial cancer; CESC cis rs116095464 0.558 rs13354585 chr5:242263 G/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.33 0.31 2.15e-7 Breast cancer; CESC cis rs7100689 0.556 rs10788541 chr10:82016530 T/G cg09936400 chr10:82049201 MAT1A 0.35 5.2 0.3 4.02e-7 Post bronchodilator FEV1; CESC cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg00745463 chr17:30367425 LRRC37B -0.88 -7.77 -0.43 1.78e-13 Hip circumference adjusted for BMI; CESC cis rs1808579 0.904 rs1618725 chr18:21126952 C/T cg14672496 chr18:21087552 C18orf8 0.41 5.94 0.34 8.82e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs7809950 0.530 rs34021916 chr7:106817901 A/G cg23024343 chr7:107201750 COG5 -0.5 -6.33 -0.36 1.05e-9 Coronary artery disease; CESC trans rs11098499 0.779 rs6815934 chr4:120267310 T/C cg25214090 chr10:38739885 LOC399744 0.59 8.14 0.45 1.55e-14 Corneal astigmatism; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg06237717 chr12:95467511 NR2C1 0.49 6.35 0.36 9.17e-10 Attention deficit hyperactivity disorder; CESC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.673 rs11657270 chr17:29214387 A/G cg19761014 chr17:28927070 LRRC37B2 0.73 5.75 0.33 2.39e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.45 5.98 0.34 7.14e-9 Colorectal cancer; CESC cis rs634534 0.622 rs593525 chr11:65727799 T/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.67 9.39 0.5 2.89e-18 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs3754214 0.823 rs496203 chr1:150270025 A/G cg09579323 chr1:150459698 TARS2 -0.47 -6.18 -0.35 2.44e-9 Cerebrospinal fluid biomarker levels; CESC cis rs17125944 0.505 rs75296244 chr14:53233218 G/A cg13660082 chr14:53194042 PSMC6 -0.67 -5.83 -0.34 1.58e-8 Alzheimer's disease (late onset); CESC cis rs7208859 0.524 rs73263982 chr17:28920624 T/C cg19761014 chr17:28927070 LRRC37B2 0.8 7.38 0.41 2.04e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg18876405 chr7:65276391 NA 0.5 5.89 0.34 1.16e-8 Aortic root size; CESC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg02038168 chr22:39784481 NA -0.65 -8.1 -0.45 2.03e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg23281280 chr6:28129359 ZNF389 -0.48 -6.82 -0.39 6.24e-11 Depression; CESC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg18765753 chr7:1198926 ZFAND2A -0.42 -6.33 -0.36 1.02e-9 Longevity;Endometriosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16303825 chr3:10362878 SEC13 -0.45 -6.25 -0.36 1.6e-9 Fibrinogen levels; CESC cis rs2985684 0.894 rs4900932 chr14:50022928 A/G cg02151108 chr14:50098012 C14orf104 -0.39 -5.31 -0.31 2.36e-7 Carotid intima media thickness; CESC cis rs2408955 0.501 rs8716 chr12:48539482 T/G cg24011408 chr12:48396354 COL2A1 0.5 7.6 0.42 5.27e-13 Glycated hemoglobin levels; CESC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg07870213 chr5:140052090 DND1 0.65 6.81 0.39 6.37e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6459804 1.000 rs6459804 chr7:157510195 C/T cg05731713 chr7:157510257 PTPRN2 0.39 6.61 0.38 2.06e-10 Bipolar disorder and schizophrenia; CESC cis rs9611565 0.765 rs132915 chr22:41805782 T/C cg17376030 chr22:41985996 PMM1 -0.59 -6.24 -0.36 1.69e-9 Vitiligo; CESC trans rs10776614 0.799 rs1965170 chr10:49764417 C/A cg19218067 chr2:181235115 NA 0.49 6.0 0.35 6.35e-9 Self-employment; CESC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -7.67 -0.43 3.25e-13 Tonsillectomy; CESC cis rs7824557 0.652 rs12677504 chr8:11133175 G/A cg21775007 chr8:11205619 TDH -0.47 -6.95 -0.39 2.78e-11 Retinal vascular caliber; CESC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.69 6.31 0.36 1.14e-9 Platelet count; CESC cis rs67478160 0.679 rs7156834 chr14:104211180 G/A cg08213375 chr14:104286397 PPP1R13B 0.54 10.85 0.55 6.32e-23 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11331422 chr19:10491258 TYK2 0.54 6.47 0.37 4.72e-10 Gut microbiome composition (summer); CESC cis rs9649465 0.935 rs3807636 chr7:123368488 G/A cg04330084 chr7:123175371 IQUB -0.39 -5.23 -0.31 3.47e-7 Migraine; CESC cis rs2933343 0.700 rs1680788 chr3:128625318 C/T cg24203234 chr3:128598194 ACAD9 0.39 5.25 0.31 3.19e-7 IgG glycosylation; CESC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg02034447 chr16:89574710 SPG7 0.52 6.66 0.38 1.6e-10 Multiple myeloma (IgH translocation); CESC cis rs35160687 0.623 rs13005014 chr2:86487216 T/C cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.18 -0.3 4.34e-7 Night sleep phenotypes; CESC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg22823121 chr1:150693482 HORMAD1 0.47 6.84 0.39 5.33e-11 Tonsillectomy; CESC cis rs9303401 0.614 rs34550282 chr17:57092788 G/A cg12560992 chr17:57184187 TRIM37 0.5 5.26 0.31 2.91e-7 Cognitive test performance; CESC cis rs9457247 1.000 rs430097 chr6:167405073 A/G cg25258033 chr6:167368657 RNASET2 0.39 5.88 0.34 1.26e-8 Crohn's disease; CESC cis rs35110281 0.744 rs162395 chr21:44945759 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -9.54 -0.51 9.94e-19 Mean corpuscular volume; CESC cis rs6032067 0.929 rs2233895 chr20:43850143 T/A cg10761708 chr20:43804764 PI3 0.5 6.12 0.35 3.3e-9 Blood protein levels; CESC cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg03467027 chr4:99064603 C4orf37 0.46 5.66 0.33 3.91e-8 Colonoscopy-negative controls vs population controls; CESC cis rs8114671 0.562 rs6087651 chr20:33518353 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.19 0.3 4.19e-7 Height; CESC cis rs4474465 1.000 rs7131199 chr11:78192148 T/G cg02023728 chr11:77925099 USP35 0.39 5.06 0.3 7.93e-7 Alzheimer's disease (survival time); CESC cis rs9308433 0.505 rs958304 chr1:214474241 C/T cg06198575 chr1:214491504 SMYD2 0.5 5.94 0.34 8.72e-9 IgG glycosylation; CESC cis rs921968 0.643 rs545460 chr2:219392159 A/G cg02176678 chr2:219576539 TTLL4 0.4 6.93 0.39 3.22e-11 Mean corpuscular hemoglobin concentration; CESC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg05564831 chr3:52568323 NT5DC2 -0.46 -6.82 -0.39 6.21e-11 Bipolar disorder; CESC cis rs3768617 0.510 rs3768622 chr1:183090011 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 13.3 0.63 2.81e-31 Fuchs's corneal dystrophy; CESC cis rs11676348 0.791 rs6726126 chr2:218952233 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.42 -5.59 -0.32 5.59e-8 Ulcerative colitis; CESC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg18337363 chr3:52569053 NT5DC2 0.28 5.13 0.3 5.59e-7 Bipolar disorder; CESC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg10691866 chr7:65817282 TPST1 -0.33 -5.43 -0.32 1.3e-7 Aortic root size; CESC cis rs2832077 1.000 rs2832077 chr21:30141021 G/A cg03476357 chr21:30257390 N6AMT1 -0.5 -5.43 -0.32 1.3e-7 Cognitive test performance; CESC cis rs1538970 0.781 rs11211139 chr1:46015751 G/T cg24296786 chr1:45957014 TESK2 -0.48 -5.14 -0.3 5.38e-7 Platelet count; CESC cis rs2933343 0.729 rs813732 chr3:128619357 C/T cg24203234 chr3:128598194 ACAD9 0.4 5.26 0.31 3.05e-7 IgG glycosylation; CESC cis rs35146811 0.807 rs6953441 chr7:99617067 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.49 6.06 0.35 4.59e-9 Coronary artery disease; CESC cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg25019033 chr10:957182 NA -0.59 -6.34 -0.36 9.88e-10 Eosinophil percentage of granulocytes; CESC cis rs7429990 0.965 rs9811277 chr3:48011638 A/G cg11946769 chr3:48343235 NME6 0.44 5.36 0.31 1.83e-7 Educational attainment (years of education); CESC cis rs3820068 0.705 rs2145396 chr1:15875184 A/G cg17385448 chr1:15911702 AGMAT 0.36 5.62 0.33 4.77e-8 Systolic blood pressure; CESC cis rs4727963 0.846 rs11772178 chr7:122707928 C/G cg03640110 chr7:122635026 TAS2R16 -0.37 -5.7 -0.33 3.11e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC trans rs637571 0.522 rs493899 chr11:65747952 A/C cg17712092 chr4:129076599 LARP1B 0.72 9.97 0.52 4.26e-20 Eosinophil percentage of white cells; CESC cis rs11785400 0.793 rs2976399 chr8:143746050 C/T cg10596483 chr8:143751796 JRK 0.42 5.26 0.31 2.94e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05312278 chr15:43803195 TP53BP1 0.61 7.0 0.4 2.1e-11 Gut microbiome composition (summer); CESC cis rs898097 0.607 rs2199111 chr17:80823203 A/G cg10494973 chr17:80897199 TBCD 0.42 5.07 0.3 7.45e-7 Breast cancer; CESC trans rs561341 0.883 rs2074102 chr17:30228884 G/A cg20587970 chr11:113659929 NA -1.08 -13.07 -0.63 1.8e-30 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2806561 0.765 rs641032 chr1:23513980 C/T cg12483005 chr1:23474871 LUZP1 -0.38 -5.97 -0.34 7.77e-9 Height; CESC cis rs734999 0.566 rs6664969 chr1:2534978 G/A cg20673091 chr1:2541236 MMEL1 0.45 7.53 0.42 8.17e-13 Ulcerative colitis; CESC cis rs7264396 0.580 rs2425181 chr20:34447709 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.85 -9.39 -0.5 2.81e-18 Total cholesterol levels; CESC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.71 0.62 3.31e-29 Gut microbiome composition (summer); CESC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg00149659 chr3:10157352 C3orf10 0.73 8.81 0.48 1.65e-16 Alzheimer's disease; CESC cis rs5769765 1.000 rs5770741 chr22:50270215 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10704137 chr6:25732153 NA 0.46 6.58 0.37 2.5e-10 Fibrinogen levels; CESC cis rs5769765 0.565 rs8137232 chr22:50256885 G/C cg02269571 chr22:50332266 NA 0.46 5.46 0.32 1.08e-7 Schizophrenia; CESC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg25767906 chr1:53392781 SCP2 -0.44 -5.51 -0.32 8.62e-8 Monocyte count; CESC cis rs8114671 0.562 rs6120757 chr20:33488771 C/T cg07148914 chr20:33460835 GGT7 0.48 6.31 0.36 1.18e-9 Height; CESC cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg05347473 chr6:146136440 FBXO30 0.59 7.63 0.42 4.24e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs2243480 1.000 rs2465120 chr7:65620974 C/G cg12463550 chr7:65579703 CRCP 0.73 5.71 0.33 3.1e-8 Diabetic kidney disease; CESC cis rs660899 0.595 rs37455 chr1:44294228 A/G cg19743044 chr1:44115203 KDM4A 0.47 6.0 0.35 6.4e-9 Hypertension risk in short sleep duration; CESC cis rs60843830 0.633 rs1078763 chr2:113763 A/G cg25945732 chr2:264204 ACP1;SH3YL1 -0.47 -5.71 -0.33 3.07e-8 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs17039065 1.000 rs72889372 chr4:109387298 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.6 5.07 0.3 7.55e-7 Gut microbiome composition (summer); CESC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg23758822 chr17:41437982 NA 1.03 14.68 0.67 3.99e-36 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00358220 chr18:3247473 MYL12A -0.47 -6.41 -0.37 6.48e-10 Fibrinogen levels; CESC cis rs977987 0.843 rs6564259 chr16:75447393 T/G cg03315344 chr16:75512273 CHST6 0.41 5.83 0.34 1.59e-8 Dupuytren's disease; CESC cis rs910316 1.000 rs11159117 chr14:75584867 C/T cg11812906 chr14:75593930 NEK9 0.9 15.46 0.69 7.06e-39 Height; CESC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg18765753 chr7:1198926 ZFAND2A -0.39 -5.65 -0.33 4.23e-8 Longevity;Endometriosis; CESC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg03013636 chr16:1946785 NA 0.4 5.52 0.32 8.17e-8 Ankle injury; CESC cis rs6142102 0.625 rs4243974 chr20:32547868 T/C cg08999081 chr20:33150536 PIGU 0.34 5.11 0.3 6.04e-7 Skin pigmentation; CESC cis rs9359856 0.529 rs56352205 chr6:90439272 C/T cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.88 -0.34 1.23e-8 Bipolar disorder; CESC cis rs1153858 0.945 rs1974981 chr15:45729123 C/T cg14582100 chr15:45693742 SPATA5L1 -0.37 -5.05 -0.3 8.25e-7 Homoarginine levels; CESC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg23283495 chr1:209979779 IRF6 0.32 5.07 0.3 7.37e-7 Monobrow; CESC cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg03213289 chr20:61660250 NA 0.4 6.13 0.35 3.1e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -7.1 -0.4 1.13e-11 Tuberculosis; CESC cis rs8017423 0.647 rs4904674 chr14:90817412 G/A cg14092571 chr14:90743983 NA 0.44 6.62 0.38 1.93e-10 Mortality in heart failure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05135541 chr1:150039387 VPS45 -0.45 -7.21 -0.4 5.92e-12 Gambling; CESC cis rs12136530 0.550 rs10753560 chr1:19708577 T/C cg01832549 chr1:19774989 CAPZB 0.46 6.06 0.35 4.62e-9 Lead levels in blood; CESC cis rs9926296 0.533 rs12102290 chr16:89812617 C/T cg04287289 chr16:89883240 FANCA 0.92 16.38 0.71 3.91e-42 Vitiligo; CESC cis rs5769765 0.773 rs9616395 chr22:50317803 A/G cg02269571 chr22:50332266 NA -0.63 -6.78 -0.38 7.82e-11 Schizophrenia; CESC cis rs9790314 0.902 rs9863590 chr3:161116445 T/C cg03342759 chr3:160939853 NMD3 -0.43 -5.5 -0.32 9.09e-8 Morning vs. evening chronotype; CESC cis rs80033912 0.713 rs7629936 chr3:49836707 G/A cg03060546 chr3:49711283 APEH 0.61 6.68 0.38 1.43e-10 Intelligence (multi-trait analysis); CESC cis rs67311347 1.000 rs11707278 chr3:40487075 A/T cg24209194 chr3:40518798 ZNF619 0.5 6.31 0.36 1.18e-9 Renal cell carcinoma; CESC cis rs4722166 0.695 rs56061963 chr7:22800397 T/C cg05472934 chr7:22766657 IL6 0.63 8.29 0.45 5.71e-15 Lung cancer; CESC cis rs4919044 0.808 rs835256 chr10:94779550 C/T cg16508068 chr10:94451736 HHEX -0.5 -5.49 -0.32 9.61e-8 Coronary artery disease; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg12121965 chr21:46293563 PTTG1IP 0.52 7.05 0.4 1.51e-11 Bronchopulmonary dysplasia; CESC trans rs11039798 1.000 rs11039978 chr11:48760237 A/G cg15704280 chr7:45808275 SEPT13 0.7 6.42 0.37 6.38e-10 Axial length; CESC cis rs7084402 0.967 rs1658470 chr10:60292383 A/G cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs2286503 1.000 rs2286498 chr7:22857504 C/T cg13679077 chr7:22862647 TOMM7 -0.39 -5.08 -0.3 7.24e-7 Fibrinogen; CESC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg19163074 chr7:65112434 INTS4L2 0.52 5.35 0.31 1.87e-7 Aortic root size; CESC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg17366294 chr4:99064904 C4orf37 0.61 8.77 0.47 2.27e-16 Colonoscopy-negative controls vs population controls; CESC cis rs644799 0.635 rs10831428 chr11:95508404 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.78 11.68 0.58 1.03e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6456156 0.586 rs12525855 chr6:167480013 T/G cg07741184 chr6:167504864 NA 0.35 6.11 0.35 3.53e-9 Primary biliary cholangitis; CESC cis rs9911578 1.000 rs2531734 chr17:56550804 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.41 -5.41 -0.32 1.38e-7 Intelligence (multi-trait analysis); CESC cis rs703842 0.928 rs724834 chr12:58180416 G/C cg04478727 chr12:58166393 METTL1;FAM119B 0.71 8.89 0.48 9.48e-17 Multiple sclerosis; CESC cis rs3892630 0.817 rs35408716 chr19:33187961 A/C cg13157960 chr19:33183277 NUDT19 0.55 5.39 0.31 1.58e-7 Red blood cell traits; CESC cis rs5743618 0.537 rs10470854 chr4:38768533 A/G cg02016764 chr4:38805732 TLR1 -0.32 -5.1 -0.3 6.49e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.36 0.41 2.27e-12 Tonsillectomy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02607779 chr2:208030673 KLF7 0.46 6.46 0.37 5e-10 Gut microbiota (bacterial taxa); CESC cis rs11077998 0.933 rs2291395 chr17:80526139 A/G cg10255544 chr17:80519551 FOXK2 0.54 8.65 0.47 4.87e-16 Reticulocyte fraction of red cells; CESC cis rs12477438 0.520 rs11677247 chr2:99756358 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.81 0.7 4.17e-40 Chronic sinus infection; CESC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg25036284 chr2:26402008 FAM59B -0.59 -6.77 -0.38 8.41e-11 Gut microbiome composition (summer); CESC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg08888203 chr3:10149979 C3orf24 0.47 5.82 0.34 1.7e-8 Alzheimer's disease; CESC cis rs6582630 0.537 rs66855609 chr12:38299029 T/C cg26384229 chr12:38710491 ALG10B 0.63 9.25 0.49 7.58e-18 Drug-induced liver injury (flucloxacillin); CESC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg21963583 chr11:68658836 MRPL21 -0.36 -5.18 -0.3 4.37e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04876968 chr17:30771485 PSMD11 0.54 6.18 0.35 2.36e-9 Gut microbiome composition (summer); CESC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg06221963 chr1:154839813 KCNN3 -0.7 -12.07 -0.6 4.9e-27 Prostate cancer; CESC cis rs7959452 0.530 rs12811632 chr12:69755003 G/A cg20891283 chr12:69753455 YEATS4 0.87 13.83 0.65 3.99e-33 Blood protein levels; CESC cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg10556349 chr10:835070 NA 0.57 5.58 0.32 6.05e-8 Eosinophil percentage of granulocytes; CESC cis rs9811920 0.570 rs1021102 chr3:99603780 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg27170947 chr2:26402098 FAM59B -0.68 -7.96 -0.44 5.12e-14 Gut microbiome composition (summer); CESC cis rs2295359 1.000 rs10889661 chr1:67625309 T/A cg03340356 chr1:67600835 NA 0.33 5.42 0.32 1.37e-7 Psoriasis; CESC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg12963246 chr6:28129442 ZNF389 0.55 6.89 0.39 4.12e-11 Parkinson's disease; CESC cis rs870825 0.616 rs6552806 chr4:185638231 C/T cg04058563 chr4:185651563 MLF1IP 0.62 6.86 0.39 4.91e-11 Blood protein levels; CESC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.31 -0.41 3.16e-12 Developmental language disorder (linguistic errors); CESC cis rs4737010 0.501 rs2111805 chr8:41643457 G/C cg08923054 chr8:41654455 ANK1 0.63 7.73 0.43 2.23e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03651904 chr19:2807229 THOP1 -0.61 -6.71 -0.38 1.17e-10 Gut microbiome composition (summer); CESC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.4 5.05 0.3 8.12e-7 Lymphocyte counts; CESC cis rs2456568 0.709 rs12806128 chr11:93634972 C/T cg26875233 chr11:93583750 C11orf90 0.28 5.03 0.3 8.9e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs7116495 1.000 rs607446 chr11:71789252 G/A cg26138937 chr11:71823887 C11orf51 -0.84 -6.79 -0.38 7.37e-11 Severe influenza A (H1N1) infection; CESC cis rs1371867 0.846 rs1660353 chr8:101250907 C/T cg11906718 chr8:101322791 RNF19A -0.41 -5.24 -0.31 3.29e-7 Atrioventricular conduction; CESC cis rs12701220 0.590 rs1881124 chr7:1096766 A/C cg26769984 chr7:1090371 C7orf50 0.57 5.89 0.34 1.19e-8 Bronchopulmonary dysplasia; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg01934962 chr17:19881077 AKAP10 -0.49 -6.28 -0.36 1.41e-9 Asthma; CESC cis rs9486719 0.895 rs12195315 chr6:96905711 T/G cg18709589 chr6:96969512 KIAA0776 -0.56 -6.11 -0.35 3.51e-9 Migraine;Coronary artery disease; CESC cis rs6460942 1.000 rs7808819 chr7:12297440 C/T cg06484146 chr7:12443880 VWDE -0.77 -8.1 -0.45 2.06e-14 Coronary artery disease; CESC cis rs8077577 0.747 rs11078415 chr17:18255498 C/T cg16794390 chr17:18148240 FLII 0.41 6.31 0.36 1.17e-9 Obesity-related traits; CESC cis rs4237845 0.537 rs11172367 chr12:58272486 T/G cg02175503 chr12:58329896 NA 0.5 6.04 0.35 5.06e-9 Intelligence (multi-trait analysis); CESC cis rs9584850 0.834 rs7334078 chr13:99120484 C/T cg20750642 chr13:99100586 FARP1 0.36 5.45 0.32 1.18e-7 Neuroticism; CESC cis rs11645898 0.935 rs4788615 chr16:72192372 G/A cg14768367 chr16:72042858 DHODH -0.79 -6.58 -0.37 2.51e-10 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17563338 chr3:125093799 ZNF148 0.63 7.06 0.4 1.42e-11 Gut microbiome composition (summer); CESC cis rs2479106 0.549 rs7862469 chr9:126391268 T/G cg16191174 chr9:126692580 DENND1A 0.39 5.49 0.32 9.18e-8 Polycystic ovary syndrome; CESC cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg25019033 chr10:957182 NA -0.57 -5.99 -0.35 6.93e-9 Eosinophil percentage of granulocytes; CESC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg02807482 chr3:125708958 NA -0.38 -5.08 -0.3 7.16e-7 Blood pressure (smoking interaction); CESC cis rs2573652 1.000 rs2573650 chr15:100514097 A/G cg09918751 chr15:100517450 ADAMTS17 0.39 7.51 0.42 8.89e-13 Height; CESC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.51e-7 Life satisfaction; CESC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.64 -8.9 -0.48 9.08e-17 Personality dimensions; CESC cis rs17253792 0.822 rs8018142 chr14:56173288 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.69 5.92 0.34 9.97e-9 Putamen volume; CESC trans rs7726839 0.540 rs56325086 chr5:640728 G/A cg25482853 chr8:67687455 SGK3 1.01 10.3 0.53 3.96e-21 Obesity-related traits; CESC trans rs10242455 0.702 rs73713507 chr7:99138603 G/A cg09045935 chr12:6379348 NA 0.9 7.0 0.4 2.04e-11 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05115182 chr10:99496889 ZFYVE27 0.62 7.59 0.42 5.52e-13 Gut microbiome composition (summer); CESC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg27588902 chr6:42928151 GNMT -0.27 -5.04 -0.3 8.61e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs17376456 0.825 rs10054903 chr5:93281491 C/A cg25358565 chr5:93447407 FAM172A 1.12 10.36 0.54 2.45e-21 Diabetic retinopathy; CESC cis rs4423214 0.879 rs1792277 chr11:71138918 C/T cg05163923 chr11:71159392 DHCR7 -0.63 -7.28 -0.41 3.75e-12 Vitamin D levels; CESC cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg25554036 chr4:6271136 WFS1 0.51 8.34 0.46 4.21e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs747782 0.536 rs10838873 chr11:48337765 T/C cg15704280 chr7:45808275 SEPT13 0.68 6.22 0.36 1.93e-9 Intraocular pressure; CESC cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.54 5.34 0.31 1.98e-7 Cerebrospinal P-tau181p levels; CESC cis rs3106136 0.967 rs72665658 chr4:95144761 C/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.01 -0.4 1.94e-11 Capecitabine sensitivity; CESC cis rs367615 0.506 rs2914684 chr5:108775110 C/T cg17395555 chr5:108820864 NA -0.58 -9.8 -0.52 1.46e-19 Colorectal cancer (SNP x SNP interaction); CESC cis rs6968419 0.755 rs2896180 chr7:115897871 A/G cg02561103 chr7:115862891 TES -0.44 -5.89 -0.34 1.14e-8 Intraocular pressure; CESC cis rs1707322 0.682 rs10890335 chr1:46100394 G/C cg05343316 chr1:45956843 TESK2 0.51 6.35 0.36 9.44e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1670533 0.872 rs11727135 chr4:1051803 G/C cg27284194 chr4:1044797 NA 0.42 5.17 0.3 4.53e-7 Recombination rate (females); CESC cis rs10492096 0.947 rs61918020 chr12:6605514 C/T cg13857086 chr12:6580257 VAMP1 0.61 6.14 0.35 3.03e-9 Hip geometry; CESC cis rs9584850 0.834 rs9584855 chr13:99119000 G/T cg20750642 chr13:99100586 FARP1 0.37 5.73 0.33 2.68e-8 Neuroticism; CESC trans rs2075371 0.932 rs1862048 chr7:133978167 C/G cg26182263 chr8:22224973 SLC39A14 0.48 6.24 0.36 1.72e-9 Mean platelet volume; CESC cis rs344364 0.511 rs337284 chr16:1954799 A/C cg26617929 chr16:1858877 NA -0.51 -5.41 -0.32 1.44e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg11764359 chr7:65958608 NA -0.8 -9.57 -0.51 7.7e-19 Aortic root size; CESC cis rs10492096 0.947 rs11064227 chr12:6598043 A/G cg13857086 chr12:6580257 VAMP1 0.62 6.19 0.36 2.24e-9 Hip geometry; CESC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg19680485 chr15:31195859 MTMR15 0.47 5.66 0.33 3.92e-8 Huntington's disease progression; CESC cis rs116095464 0.558 rs9654452 chr5:299561 C/T cg20965017 chr5:231967 SDHA -0.48 -5.41 -0.32 1.41e-7 Breast cancer; CESC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.37 -5.44 -0.32 1.19e-7 Total body bone mineral density; CESC cis rs644799 0.544 rs1527450 chr11:95467777 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.49 6.38 0.37 7.7e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg08859206 chr1:53392774 SCP2 -0.69 -10.44 -0.54 1.33e-21 Monocyte count; CESC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg18190219 chr22:46762943 CELSR1 -0.59 -6.62 -0.38 1.94e-10 LDL cholesterol;Cholesterol, total; CESC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg16606324 chr3:10149918 C3orf24 0.43 5.35 0.31 1.91e-7 Alzheimer's disease; CESC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.97e-7 Life satisfaction; CESC cis rs738322 0.753 rs2267372 chr22:38598234 A/G cg25457927 chr22:38595422 NA 0.32 5.83 0.34 1.57e-8 Cutaneous nevi; CESC cis rs2239547 0.657 rs7620706 chr3:52891756 A/T cg11645453 chr3:52864694 ITIH4 0.33 5.86 0.34 1.37e-8 Schizophrenia; CESC cis rs11792861 0.851 rs17552292 chr9:111891954 C/T cg13535736 chr9:111863775 C9orf5 -0.5 -6.61 -0.38 2.12e-10 Menarche (age at onset); CESC cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg10556349 chr10:835070 NA 0.76 6.35 0.36 9.42e-10 Eosinophil percentage of granulocytes; CESC cis rs7000551 0.688 rs2948145 chr8:22367792 T/C cg12081754 chr8:22256438 SLC39A14 0.39 5.2 0.3 4.06e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg23281280 chr6:28129359 ZNF389 0.4 5.8 0.34 1.88e-8 Parkinson's disease; CESC cis rs11792861 0.926 rs12686736 chr9:111888739 A/G cg13535736 chr9:111863775 C9orf5 -0.5 -6.5 -0.37 4.04e-10 Menarche (age at onset); CESC cis rs37004 0.748 rs380145 chr5:1328897 C/T cg07493874 chr5:1342172 CLPTM1L -0.43 -5.54 -0.32 7.17e-8 Prostate-specific antigen levels; CESC cis rs6964587 1.000 rs4265 chr7:91719608 A/G cg17063962 chr7:91808500 NA -0.56 -7.8 -0.43 1.39e-13 Breast cancer; CESC trans rs9929218 0.954 rs4420522 chr16:68822971 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.13 -0.45 1.69e-14 Colorectal cancer; CESC cis rs11649653 0.502 rs4889490 chr16:30823047 A/C cg02466173 chr16:30829666 NA -0.42 -6.64 -0.38 1.81e-10 Triglycerides; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18146300 chr17:17184632 COPS3 -0.59 -6.78 -0.38 7.67e-11 Gut microbiome composition (summer); CESC cis rs7395581 0.918 rs3847502 chr11:47333685 C/A cg25783544 chr11:47291846 MADD 0.61 8.04 0.44 2.9e-14 HDL cholesterol; CESC cis rs4423214 1.000 rs2002063 chr11:71163476 T/C cg05163923 chr11:71159392 DHCR7 0.75 10.18 0.53 9.28e-21 Vitamin D levels; CESC cis rs7927592 0.513 rs901823 chr11:68205578 T/C cg01657329 chr11:68192670 LRP5 -0.56 -7.24 -0.41 4.81e-12 Total body bone mineral density; CESC cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.35 0.46 3.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7580658 0.963 rs2090574 chr2:128131391 C/A cg10021288 chr2:128175891 PROC -0.41 -6.47 -0.37 4.66e-10 Protein C levels; CESC cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg20476274 chr7:133979776 SLC35B4 0.65 9.41 0.5 2.53e-18 Mean platelet volume; CESC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.34 0.54 2.83e-21 Prudent dietary pattern; CESC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.52 0.37 3.49e-10 Prudent dietary pattern; CESC cis rs9902453 0.791 rs28492945 chr17:28223982 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 9.07 0.49 2.73e-17 Coffee consumption (cups per day); CESC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg07677032 chr17:61819896 STRADA 0.5 6.7 0.38 1.27e-10 Prudent dietary pattern; CESC cis rs703842 0.963 rs2069506 chr12:58142854 C/A cg04478727 chr12:58166393 METTL1;FAM119B 0.7 8.87 0.48 1.09e-16 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26581886 chr22:17090862 psiTPTE22 -0.55 -7.1 -0.4 1.18e-11 Gut microbiome composition (summer); CESC cis rs4803468 0.901 rs3745292 chr19:41888506 A/G cg14132834 chr19:41945861 ATP5SL -0.61 -7.79 -0.43 1.56e-13 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18045461 chr22:29601862 EMID1 -0.46 -6.14 -0.35 3.08e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs782590 0.608 rs10207590 chr2:55921782 G/C cg18811423 chr2:55921094 PNPT1 -0.73 -11.35 -0.57 1.37e-24 Metabolic syndrome; CESC cis rs73110464 0.609 rs727266 chr12:53356411 C/T cg25025879 chr12:53359317 NA -0.58 -7.72 -0.43 2.43e-13 Cancer (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13047596 chr2:233735017 C2orf82 -0.6 -6.84 -0.39 5.41e-11 Gut microbiome composition (summer); CESC cis rs2228479 0.717 rs1007932 chr16:89838541 C/T cg04287289 chr16:89883240 FANCA 0.72 6.14 0.35 3.05e-9 Skin colour saturation; CESC cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.7 -8.1 -0.45 1.99e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4704187 0.687 rs12653162 chr5:74391666 C/T cg03227963 chr5:74354835 NA 0.32 5.93 0.34 9.57e-9 Response to amphetamines; CESC cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.72 8.98 0.48 5.29e-17 Age-related macular degeneration (geographic atrophy); CESC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg25985355 chr7:65971099 NA -0.31 -5.14 -0.3 5.4e-7 Aortic root size; CESC cis rs7586673 0.866 rs747003 chr2:161916409 C/T cg16506815 chr2:162101123 NA -0.43 -5.96 -0.34 8.23e-9 Intelligence (multi-trait analysis); CESC cis rs425277 0.585 rs3107143 chr1:2045372 G/C cg23803603 chr1:2058230 PRKCZ -0.35 -6.12 -0.35 3.38e-9 Height; CESC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg04414720 chr1:150670196 GOLPH3L 0.56 7.41 0.41 1.68e-12 Melanoma; CESC cis rs2645694 0.626 rs2703136 chr4:77828957 T/A cg10057126 chr4:77819792 ANKRD56 0.6 8.46 0.46 1.79e-15 Emphysema distribution in smoking; CESC cis rs941408 0.515 rs878893 chr19:2781325 A/G cg02580895 chr19:2754563 NA -0.41 -5.2 -0.3 3.97e-7 Total cholesterol levels; CESC cis rs79839061 0.520 rs11730111 chr4:942833 C/T cg07828340 chr4:882639 GAK 1.09 7.84 0.43 1.13e-13 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23561859 chr2:96931676 CIAO1;TMEM127 0.58 6.57 0.37 2.66e-10 Gut microbiome composition (summer); CESC cis rs752010 0.630 rs11210507 chr1:42105488 T/C cg06885757 chr1:42089581 HIVEP3 0.48 7.76 0.43 1.8e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg03609598 chr5:56110824 MAP3K1 -0.54 -5.69 -0.33 3.42e-8 Initial pursuit acceleration; CESC cis rs589448 0.902 rs315113 chr12:69786543 G/T cg14784868 chr12:69753453 YEATS4 -0.74 -11.21 -0.57 3.99e-24 Cerebrospinal fluid biomarker levels; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg14245309 chr7:75677153 STYXL1;MDH2 0.5 6.38 0.36 7.91e-10 Attention deficit hyperactivity disorder; CESC cis rs1348850 0.915 rs10930798 chr2:178446141 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.31 0.45 5.02e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.43 -5.38 -0.31 1.64e-7 Tonsillectomy; CESC cis rs1348850 0.958 rs4243390 chr2:178468008 G/A cg23306229 chr2:178417860 TTC30B 0.61 8.12 0.45 1.76e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6500395 0.962 rs9923371 chr16:48628015 C/T cg04672837 chr16:48644449 N4BP1 0.52 6.64 0.38 1.81e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg10691866 chr7:65817282 TPST1 0.31 5.07 0.3 7.31e-7 Aortic root size; CESC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg05025164 chr4:1340916 KIAA1530 0.87 11.81 0.59 3.81e-26 Longevity; CESC trans rs1945213 0.694 rs7131381 chr11:55858158 T/G cg03929089 chr4:120376271 NA 0.77 7.35 0.41 2.48e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs7659604 0.540 rs67150579 chr4:122704331 T/A cg19671926 chr4:122722719 EXOSC9 0.67 8.91 0.48 8.57e-17 Type 2 diabetes; CESC cis rs9902453 1.000 rs4075623 chr17:28386526 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.08e-13 Coffee consumption (cups per day); CESC cis rs7940866 0.838 rs12790299 chr11:130803634 A/G cg12179176 chr11:130786555 SNX19 0.66 9.98 0.52 3.99e-20 Schizophrenia; CESC cis rs17253792 0.822 rs10142757 chr14:56074211 C/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs8126001 0.573 rs7271530 chr20:62727915 A/G cg07246713 chr20:62722933 OPRL1 -0.31 -5.15 -0.3 5.02e-7 Pulse pressure;Mean corpuscular volume; CESC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.62 0.33 4.92e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20070536 chr11:9335581 TMEM41B -0.53 -6.35 -0.36 9.24e-10 Gut microbiome composition (summer); CESC cis rs6840258 0.941 rs72667757 chr4:87946994 C/A cg08197287 chr4:87952173 AFF1 -0.4 -5.12 -0.3 6.02e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg22800045 chr5:56110881 MAP3K1 0.82 10.34 0.54 2.87e-21 Initial pursuit acceleration; CESC cis rs2415984 0.562 rs12882684 chr14:46931802 C/T cg14871534 chr14:47121158 RPL10L 0.4 5.74 0.33 2.63e-8 Number of children ever born; CESC cis rs2230307 0.572 rs11166408 chr1:100641350 A/T cg24955406 chr1:100503596 HIAT1 -0.5 -5.03 -0.3 9.2e-7 Carotid intima media thickness; CESC cis rs897984 0.762 rs1870293 chr16:30970941 T/C cg02466173 chr16:30829666 NA 0.52 8.55 0.46 1e-15 Dementia with Lewy bodies; CESC cis rs6460942 0.915 rs62447640 chr7:12488282 A/T cg20607287 chr7:12443886 VWDE -0.77 -8.71 -0.47 3.35e-16 Coronary artery disease; CESC trans rs1814175 0.534 rs1983448 chr11:49933856 C/A cg03929089 chr4:120376271 NA -0.92 -14.95 -0.68 4.61e-37 Height; CESC cis rs4803468 1.000 rs17318666 chr19:41940342 T/G cg14132834 chr19:41945861 ATP5SL 0.69 8.61 0.47 6.75e-16 Height; CESC cis rs1023500 0.596 rs133352 chr22:42434022 C/A cg15557168 chr22:42548783 NA -0.44 -6.15 -0.35 2.8e-9 Schizophrenia; CESC cis rs4588572 0.643 rs6874309 chr5:77774498 A/T cg11547950 chr5:77652471 NA 0.46 5.78 0.33 2.11e-8 Triglycerides; CESC cis rs9399135 0.967 rs6909975 chr6:135315570 C/T cg22676075 chr6:135203613 NA 0.5 6.87 0.39 4.48e-11 Red blood cell count; CESC cis rs6060717 0.536 rs8125393 chr20:34496162 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 5.45 0.32 1.15e-7 Hip circumference adjusted for BMI; CESC cis rs4986811 1.000 rs7936152 chr11:32453622 A/G cg27409910 chr11:32454216 WT1 -0.45 -6.04 -0.35 5.12e-9 Rubella-specific interleukin-6 secretion; CESC cis rs4474465 0.679 rs10899537 chr11:78222424 C/G cg27205649 chr11:78285834 NARS2 0.44 5.27 0.31 2.83e-7 Alzheimer's disease (survival time); CESC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg08027265 chr7:2291960 NA -0.36 -5.47 -0.32 1.05e-7 Bipolar disorder and schizophrenia; CESC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg22800045 chr5:56110881 MAP3K1 0.81 10.03 0.52 2.74e-20 Initial pursuit acceleration; CESC cis rs36051895 0.632 rs7849717 chr9:5170080 G/A cg02405213 chr9:5042618 JAK2 -0.51 -5.89 -0.34 1.17e-8 Pediatric autoimmune diseases; CESC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg22823121 chr1:150693482 HORMAD1 0.48 7.1 0.4 1.14e-11 Tonsillectomy; CESC cis rs9837602 0.630 rs73138610 chr3:99683653 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 5.08 0.3 7.05e-7 Breast cancer; CESC cis rs4780401 0.609 rs11639945 chr16:11824056 T/G cg01061890 chr16:11836724 TXNDC11 -0.56 -7.71 -0.43 2.51e-13 Rheumatoid arthritis; CESC cis rs7246865 0.510 rs3816549 chr19:17173937 G/A cg16202187 chr19:17186497 HAUS8;MYO9B 0.48 6.28 0.36 1.38e-9 Reticulocyte fraction of red cells; CESC cis rs3126085 0.935 rs877776 chr1:152178018 C/G cg26876637 chr1:152193138 HRNR 0.46 5.33 0.31 2.06e-7 Atopic dermatitis; CESC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg07677032 chr17:61819896 STRADA 0.46 6.21 0.36 2.06e-9 Prudent dietary pattern; CESC trans rs116095464 0.558 rs6874745 chr5:264527 A/G cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.38e-11 Breast cancer; CESC cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg22467129 chr15:76604101 ETFA 0.38 5.95 0.34 8.43e-9 Blood metabolite levels; CESC cis rs2963155 0.518 rs862489 chr5:142634355 T/C cg17617527 chr5:142782415 NR3C1 0.84 7.84 0.43 1.08e-13 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17436476 chr1:62120002 NA -0.5 -6.14 -0.35 3.06e-9 Gut microbiome composition (summer); CESC cis rs7819412 0.807 rs10105315 chr8:10932203 G/C cg21775007 chr8:11205619 TDH -0.43 -6.04 -0.35 5.25e-9 Triglycerides; CESC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.71e-16 Initial pursuit acceleration; CESC cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.86 8.98 0.48 5.03e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9911578 1.000 rs4793950 chr17:56593111 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.42 -5.63 -0.33 4.54e-8 Intelligence (multi-trait analysis); CESC trans rs61931739 0.500 rs11053280 chr12:34559297 G/T cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC cis rs1348850 0.914 rs10170667 chr2:178336878 A/G cg22681709 chr2:178499509 PDE11A -0.44 -6.21 -0.36 2.1e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9790314 0.875 rs336582 chr3:161082659 C/T cg04691961 chr3:161091175 C3orf57 -0.39 -5.08 -0.3 7.17e-7 Morning vs. evening chronotype; CESC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.43e-28 Prudent dietary pattern; CESC cis rs7296418 0.885 rs1716184 chr12:123637509 G/C cg00376283 chr12:123451042 ABCB9 0.68 9.5 0.5 1.29e-18 Platelet count; CESC cis rs11190604 1.000 rs2295770 chr10:102239829 G/A cg07080220 chr10:102295463 HIF1AN 0.56 5.59 0.32 5.61e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs7917772 0.599 rs2863717 chr10:104519829 A/G cg04362960 chr10:104952993 NT5C2 0.46 5.27 0.31 2.86e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9768139 0.566 rs729099 chr7:158114152 C/T cg06219351 chr7:158114137 PTPRN2 -0.72 -12.01 -0.59 8.22e-27 Calcium levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02838608 chr17:47438799 ZNF652 0.44 6.48 0.37 4.56e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.23 0.53 6.6e-21 Prudent dietary pattern; CESC cis rs1215050 0.782 rs6532693 chr4:98655815 T/C cg05340658 chr4:99064831 C4orf37 -0.47 -6.04 -0.35 5.08e-9 Waist-to-hip ratio adjusted for body mass index; CESC trans rs17764205 0.777 rs10424519 chr19:3253532 C/G cg12868887 chr11:70244470 CTTN -0.75 -6.27 -0.36 1.43e-9 Bipolar disorder and schizophrenia; CESC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg17372223 chr3:52568218 NT5DC2 0.43 6.34 0.36 1e-9 Bipolar disorder; CESC cis rs6690583 0.623 rs6700723 chr1:85514234 C/T cg22488158 chr1:85528044 WDR63 0.53 5.38 0.31 1.63e-7 Serum sulfate level; CESC cis rs763014 0.931 rs2071982 chr16:630405 T/G cg09263875 chr16:632152 PIGQ 0.67 11.07 0.56 1.14e-23 Height; CESC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg00750074 chr16:89608354 SPG7 -0.46 -6.85 -0.39 5.16e-11 Multiple myeloma (IgH translocation); CESC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg26335602 chr6:28129616 ZNF389 0.53 7.0 0.4 2.1e-11 Depression; CESC cis rs12497850 1.000 rs6788650 chr3:48749543 T/C cg07636037 chr3:49044803 WDR6 0.94 16.14 0.7 2.75e-41 Parkinson's disease; CESC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg24503407 chr1:205819492 PM20D1 0.81 13.38 0.63 1.55e-31 Menarche (age at onset); CESC cis rs769267 0.864 rs7245983 chr19:19657632 A/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.76 0.33 2.34e-8 Tonsillectomy; CESC cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg25427524 chr10:38739819 LOC399744 -0.65 -9.48 -0.5 1.51e-18 Extrinsic epigenetic age acceleration; CESC cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.25 0.31 3.12e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24098762 chr5:137667672 CDC25C -0.54 -6.81 -0.39 6.48e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg22823121 chr1:150693482 HORMAD1 0.48 7.11 0.4 1.11e-11 Tonsillectomy; CESC cis rs6460942 1.000 rs73053531 chr7:12317474 T/C cg02935154 chr7:12443704 VWDE -0.59 -5.84 -0.34 1.5e-8 Coronary artery disease; CESC trans rs11098499 0.863 rs7695620 chr4:120452776 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.47e-19 Corneal astigmatism; CESC trans rs61931739 0.500 rs11052990 chr12:34058647 T/A cg26384229 chr12:38710491 ALG10B 0.6 8.36 0.46 3.68e-15 Morning vs. evening chronotype; CESC cis rs4727963 0.846 rs2140854 chr7:122718310 G/A cg03640110 chr7:122635026 TAS2R16 -0.36 -5.48 -0.32 9.74e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs4077515 1.000 rs11145763 chr9:139263596 A/C cg14169450 chr9:139327907 INPP5E 0.35 5.08 0.3 7.21e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs17209837 0.607 rs17149644 chr7:87086218 T/C cg00919237 chr7:87102261 ABCB4 -0.51 -6.58 -0.37 2.45e-10 Gallbladder cancer; CESC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg22433210 chr17:43662623 NA -0.91 -10.77 -0.55 1.15e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs11098499 1.000 rs28419773 chr4:120211061 T/C cg24375607 chr4:120327624 NA 0.42 5.03 0.3 8.94e-7 Corneal astigmatism; CESC cis rs7089973 0.872 rs36036948 chr10:116631649 A/G cg23260525 chr10:116636907 FAM160B1 0.38 6.41 0.37 6.7e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs911555 0.504 rs745079 chr14:104073551 G/A cg12935359 chr14:103987150 CKB -0.5 -7.3 -0.41 3.29e-12 Intelligence (multi-trait analysis); CESC cis rs9815354 1.000 rs3774372 chr3:41877414 A/G cg03022575 chr3:42003672 ULK4 0.6 6.06 0.35 4.57e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs8067354 0.872 rs2645483 chr17:57848184 T/G cg02344993 chr17:57696989 CLTC 0.48 6.21 0.36 2.06e-9 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22902534 chr3:183892754 AP2M1 0.58 6.81 0.39 6.33e-11 Gut microbiome composition (summer); CESC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg20887711 chr4:1340912 KIAA1530 -0.61 -8.28 -0.45 6.08e-15 Obesity-related traits; CESC cis rs6701037 0.555 rs10912898 chr1:175120469 A/G cg08873628 chr1:175162347 KIAA0040 -0.4 -5.24 -0.31 3.31e-7 Alcohol dependence; CESC trans rs17508449 0.819 rs74524050 chr1:114231207 T/C cg23028848 chr11:57092561 TNKS1BP1 -0.79 -6.25 -0.36 1.63e-9 Leprosy; CESC cis rs2243480 0.901 rs13237344 chr7:66022256 T/A cg13147721 chr7:65941812 NA -0.94 -8.88 -0.48 1.06e-16 Diabetic kidney disease; CESC cis rs17253792 0.822 rs74053651 chr14:56125366 C/T cg01858014 chr14:56050164 KTN1 -0.71 -6.19 -0.36 2.22e-9 Putamen volume; CESC cis rs909002 0.789 rs56074668 chr1:32123801 T/C cg13919466 chr1:32135498 COL16A1 -0.49 -8.9 -0.48 8.83e-17 Intelligence (multi-trait analysis); CESC trans rs2983496 0.901 rs3008023 chr6:166033557 G/A cg21896720 chr4:4673378 NA 0.62 6.06 0.35 4.64e-9 Cortisol levels (saliva); CESC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg25072359 chr17:41440525 NA 0.46 6.1 0.35 3.77e-9 Menopause (age at onset); CESC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg11644478 chr21:40555479 PSMG1 -0.81 -11.65 -0.58 1.35e-25 Cognitive function; CESC cis rs941873 0.900 rs4979861 chr10:81131595 A/G cg11057378 chr10:81107060 PPIF 0.35 5.51 0.32 8.54e-8 Height; CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg15147215 chr3:52552868 STAB1 -0.38 -6.91 -0.39 3.57e-11 Electroencephalogram traits; CESC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg08392591 chr16:89556376 ANKRD11 0.64 8.68 0.47 4.24e-16 Multiple myeloma (IgH translocation); CESC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.09 0.6 4.15e-27 Alzheimer's disease; CESC cis rs2213920 0.516 rs13301972 chr9:118158086 C/T cg13918206 chr9:118159781 DEC1 -0.69 -5.52 -0.32 8.06e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CESC cis rs6662572 0.901 rs58692133 chr1:46067269 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 5.69 0.33 3.39e-8 Blood protein levels; CESC cis rs7216064 0.531 rs62084683 chr17:66031725 A/G cg12091567 chr17:66097778 LOC651250 0.87 11.37 0.57 1.14e-24 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05008406 chr3:118959563 B4GALT4 0.53 6.0 0.35 6.42e-9 Gut microbiome composition (summer); CESC cis rs11583043 1.000 rs7541397 chr1:101322866 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.53 -6.2 -0.36 2.18e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs6570726 0.643 rs9403735 chr6:145936591 C/T cg05347473 chr6:146136440 FBXO30 0.57 7.27 0.41 4.11e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03834592 chr13:113534800 ATP11A 0.46 6.11 0.35 3.59e-9 Fibrinogen levels; CESC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg19468946 chr17:37922297 IKZF3 0.39 5.07 0.3 7.62e-7 Glomerular filtration rate (creatinine); CESC cis rs3741798 1.000 rs61922047 chr12:12496471 C/A cg08615371 chr12:12503544 MANSC1 0.79 5.65 0.33 4.22e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7208859 0.673 rs216420 chr17:28938508 C/T cg19761014 chr17:28927070 LRRC37B2 0.79 7.2 0.4 6.29e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg11764359 chr7:65958608 NA 0.79 11.17 0.57 5.2e-24 Aortic root size; CESC cis rs72634258 0.699 rs2493214 chr1:7994420 A/G cg25007680 chr1:8021821 PARK7 0.44 5.1 0.3 6.63e-7 Inflammatory bowel disease; CESC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.93 0.39 3.13e-11 Bipolar disorder; CESC cis rs3749237 0.595 rs3924462 chr3:49524236 T/G cg03060546 chr3:49711283 APEH 0.77 11.82 0.59 3.5e-26 Resting heart rate; CESC cis rs72781680 1.000 rs56104215 chr2:24133590 T/C cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs1728785 1.000 rs1728792 chr16:68596534 G/C cg02972257 chr16:68554789 NA -0.59 -6.75 -0.38 9.22e-11 Ulcerative colitis; CESC cis rs2304069 0.526 rs6863283 chr5:149402448 C/A cg12661370 chr5:149340060 SLC26A2 0.43 5.62 0.33 4.77e-8 HIV-1 control; CESC cis rs9611565 0.765 rs132914 chr22:41805749 T/C cg17376030 chr22:41985996 PMM1 -0.59 -6.24 -0.36 1.69e-9 Vitiligo; CESC cis rs1062177 0.855 rs919263 chr5:151265853 A/G cg12924095 chr5:151150029 G3BP1 0.45 6.26 0.36 1.52e-9 Preschool internalizing problems; CESC trans rs7246760 0.867 rs66464474 chr19:9795149 T/C cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs561341 0.883 rs72821942 chr17:30234460 C/T cg19193384 chr17:30244184 NA -0.56 -5.74 -0.33 2.61e-8 Hip circumference adjusted for BMI; CESC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg21963583 chr11:68658836 MRPL21 0.36 5.08 0.3 7.2e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7940866 0.804 rs10894289 chr11:130808685 C/T cg12179176 chr11:130786555 SNX19 0.67 10.35 0.54 2.63e-21 Schizophrenia; CESC cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg02551604 chr5:131831745 NA -0.37 -5.22 -0.31 3.53e-7 Asthma (sex interaction); CESC cis rs36051895 0.632 rs7022901 chr9:5177680 C/G cg02405213 chr9:5042618 JAK2 -0.51 -6.55 -0.37 2.92e-10 Pediatric autoimmune diseases; CESC cis rs7264396 0.836 rs1886695 chr20:34180535 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.6 7.1 0.4 1.15e-11 Total cholesterol levels; CESC cis rs1008375 1.000 rs10011865 chr4:17645710 G/A cg16339924 chr4:17578868 LAP3 0.56 7.02 0.4 1.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg00761755 chr17:1531579 SLC43A2 -0.53 -6.11 -0.35 3.61e-9 Subjective well-being; CESC cis rs1511802 0.666 rs62350519 chr4:187119701 G/A cg24794857 chr4:187113578 CYP4V2 0.44 5.72 0.33 2.83e-8 Blood protein levels; CESC cis rs854765 0.533 rs2955354 chr17:17948716 G/C cg16928487 chr17:17741425 SREBF1 0.55 9.13 0.49 1.86e-17 Total body bone mineral density; CESC cis rs2732480 0.538 rs1387259 chr12:48703522 C/T cg04545296 chr12:48745243 ZNF641 -0.43 -7.15 -0.4 8.3e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs11122272 0.677 rs2808615 chr1:231550171 G/A cg06096015 chr1:231504339 EGLN1 -0.41 -5.78 -0.33 2.13e-8 Hemoglobin concentration; CESC cis rs7772486 0.782 rs7747576 chr6:146277827 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -13.15 -0.63 9.83e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs1538970 0.924 rs11211117 chr1:45930246 C/T cg03146154 chr1:46216737 IPP 0.45 5.24 0.31 3.31e-7 Platelet count; CESC cis rs3126085 0.935 rs1390490 chr1:152161354 T/C cg03465714 chr1:152285911 FLG -0.45 -5.39 -0.31 1.59e-7 Atopic dermatitis; CESC cis rs35955747 0.811 rs9606835 chr22:31766960 A/C cg25791279 chr22:32026902 PISD 0.48 5.79 0.34 1.97e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs1008375 0.900 rs12650220 chr4:17595365 A/T cg16339924 chr4:17578868 LAP3 0.66 8.49 0.46 1.47e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.09 -12.43 -0.61 2.89e-28 Gut microbiome composition (summer); CESC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg23281280 chr6:28129359 ZNF389 0.37 5.42 0.32 1.33e-7 Parkinson's disease; CESC cis rs3806843 1.000 rs10477033 chr5:140169603 G/C cg26395211 chr5:140044315 WDR55 -0.42 -5.59 -0.32 5.6e-8 Depressive symptoms (multi-trait analysis); CESC cis rs1865721 1.000 rs62089509 chr18:73194519 G/A cg26385618 chr18:73139727 C18orf62 -0.51 -7.6 -0.42 5.1e-13 Intelligence; CESC cis rs977987 0.815 rs11149821 chr16:75422817 C/T cg03315344 chr16:75512273 CHST6 0.4 5.74 0.33 2.62e-8 Dupuytren's disease; CESC cis rs3947 1.000 rs1736081 chr8:11702840 T/G cg00262122 chr8:11665843 FDFT1 -0.51 -5.13 -0.3 5.47e-7 Blood protein levels; CESC cis rs7312933 0.558 rs11181502 chr12:42823833 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.41 0.37 6.61e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs5167 0.586 rs4803774 chr19:45450872 A/G cg09555818 chr19:45449301 APOC2 0.43 6.72 0.38 1.08e-10 Blood protein levels; CESC cis rs11785400 0.793 rs3735993 chr8:143741170 G/A cg24634471 chr8:143751801 JRK 0.44 5.55 0.32 7.02e-8 Schizophrenia; CESC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg18337363 chr3:52569053 NT5DC2 0.3 5.57 0.32 6.38e-8 Electroencephalogram traits; CESC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg12311346 chr5:56204834 C5orf35 -0.45 -5.49 -0.32 9.29e-8 Coronary artery disease; CESC cis rs2204008 0.805 rs11522896 chr12:38234427 T/C cg26384229 chr12:38710491 ALG10B 0.73 10.35 0.54 2.55e-21 Bladder cancer; CESC cis rs34779708 0.931 rs11592404 chr10:35273476 G/A cg03585969 chr10:35415529 CREM 0.77 10.16 0.53 1.05e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg23708337 chr7:1209742 NA 0.54 5.38 0.31 1.61e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7223966 1.000 rs16947014 chr17:61719032 C/T cg11494091 chr17:61959527 GH2 0.38 5.03 0.3 9.02e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs11048434 0.666 rs12371786 chr12:9090086 G/A cg04155231 chr12:9217510 LOC144571 0.33 5.35 0.31 1.93e-7 Sjögren's syndrome; CESC cis rs2952156 0.920 rs2934951 chr17:37833328 A/G cg07936489 chr17:37558343 FBXL20 -0.58 -7.28 -0.41 3.77e-12 Asthma; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg15961887 chr4:71554203 UTP3 -0.48 -6.32 -0.36 1.11e-9 Ulcerative colitis; CESC cis rs6831352 0.918 rs13129488 chr4:100053025 G/T cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs34172651 0.617 rs9922436 chr16:24704490 C/G cg04756594 chr16:24857601 SLC5A11 0.53 6.73 0.38 1.04e-10 Intelligence (multi-trait analysis); CESC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.1 -12.68 -0.61 4e-29 Gut microbiome composition (summer); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg27360527 chr16:85722694 GINS2 0.45 6.0 0.35 6.56e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2797160 0.935 rs926855 chr6:126021782 A/G cg05901451 chr6:126070800 HEY2 0.45 6.48 0.37 4.36e-10 Endometrial cancer; CESC cis rs362272 0.505 rs3129310 chr4:3301388 T/G cg14583973 chr4:3374767 RGS12 0.3 5.13 0.3 5.52e-7 Serum sulfate level; CESC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg22920501 chr2:26401640 FAM59B -0.67 -8.09 -0.44 2.22e-14 Gut microbiome composition (summer); CESC cis rs7208859 0.573 rs73267865 chr17:29064204 C/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg22974920 chr21:40686053 BRWD1 -0.42 -5.19 -0.3 4.13e-7 Cognitive function; CESC cis rs644799 0.509 rs561635 chr11:95634232 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.4 -5.19 -0.3 4.14e-7 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11078597 0.731 rs62090051 chr17:1640640 C/G cg18436246 chr17:1640651 WDR81 0.62 7.59 0.42 5.36e-13 Serum albumin level; CESC cis rs2281558 0.876 rs2281562 chr20:25273362 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.62 8.23 0.45 8.83e-15 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs853679 0.825 rs8180562 chr6:28141460 G/A cg18032046 chr6:28092343 ZSCAN16 -0.75 -6.42 -0.37 6.32e-10 Depression; CESC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg07952391 chr2:88470173 THNSL2 0.62 6.03 0.35 5.61e-9 Plasma clusterin levels; CESC cis rs6800768 0.663 rs12492765 chr3:24091865 C/T cg10674438 chr3:24145617 LOC152024 -0.4 -5.48 -0.32 1.01e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18865796 chr19:11457210 TMEM205;CCDC159 -0.43 -6.02 -0.35 5.74e-9 Fibrinogen levels; CESC cis rs17125944 0.505 rs77433996 chr14:53212263 G/A cg00686598 chr14:53173677 PSMC6 1.33 11.43 0.57 7.31e-25 Alzheimer's disease (late onset); CESC cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2952156 0.883 rs2941505 chr17:37832704 A/G cg00129232 chr17:37814104 STARD3 -0.74 -10.19 -0.53 8.45e-21 Asthma; CESC cis rs807669 0.903 rs1771540 chr22:19173933 T/A cg02655711 chr22:19163373 SLC25A1 0.96 14.54 0.67 1.32e-35 Metabolite levels; CESC cis rs8077577 0.671 rs9910090 chr17:18250399 A/C cg16794390 chr17:18148240 FLII 0.38 6.29 0.36 1.34e-9 Obesity-related traits; CESC trans rs17508449 0.819 rs6678422 chr1:114204700 A/G cg04711050 chr9:4490757 SLC1A1 -0.68 -6.18 -0.35 2.41e-9 Leprosy; CESC cis rs7833790 0.676 rs7834555 chr8:82697625 A/G cg06027949 chr8:82754900 SNX16 -0.43 -5.22 -0.31 3.66e-7 Diastolic blood pressure; CESC trans rs55728055 0.661 rs5753700 chr22:31971258 C/T cg09557462 chr8:26721736 ADRA1A -0.56 -6.25 -0.36 1.62e-9 Age-related hearing impairment; CESC cis rs11122272 0.701 rs1009227 chr1:231480507 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.41 0.37 6.78e-10 Hemoglobin concentration; CESC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg24675658 chr1:53192096 ZYG11B 0.5 6.18 0.36 2.34e-9 Monocyte count; CESC cis rs17253792 0.822 rs9323289 chr14:56106784 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.79 6.04 0.35 5.13e-9 Putamen volume; CESC cis rs9486719 1.000 rs1303852 chr6:96864523 C/T cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs2204008 0.658 rs12371956 chr12:38298010 A/T cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Bladder cancer; CESC cis rs10905065 0.965 rs2244755 chr10:5754611 G/A cg11519256 chr10:5708881 ASB13 0.44 5.85 0.34 1.43e-8 Menopause (age at onset); CESC cis rs11098499 0.863 rs3775847 chr4:120447642 A/C cg09307838 chr4:120376055 NA 0.92 12.61 0.61 7.4e-29 Corneal astigmatism; CESC cis rs10791323 0.569 rs1119852 chr11:133743022 C/A cg15485101 chr11:133734466 NA 0.3 5.22 0.31 3.6e-7 Childhood ear infection; CESC cis rs4820539 1.000 rs4822360 chr22:23482460 A/G cg14186256 chr22:23484241 RTDR1 0.79 13.92 0.65 1.96e-33 Bone mineral density; CESC cis rs258892 0.947 rs266448 chr5:72182229 G/A cg21869765 chr5:72125136 TNPO1 0.44 5.57 0.32 6.25e-8 Small cell lung carcinoma; CESC cis rs611744 0.538 rs2298605 chr8:109272006 T/C cg21045802 chr8:109455806 TTC35 0.56 6.95 0.39 2.89e-11 Dupuytren's disease; CESC cis rs11098499 0.954 rs11098526 chr4:120390359 C/T cg24375607 chr4:120327624 NA 0.45 5.55 0.32 6.9e-8 Corneal astigmatism; CESC cis rs6499129 0.558 rs60626639 chr16:67625797 A/G cg26727032 chr16:67993705 SLC12A4 -0.6 -7.3 -0.41 3.36e-12 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4820294 1.000 rs929039 chr22:38071511 T/C cg21798802 chr22:38057573 PDXP 0.47 8.03 0.44 3.15e-14 Fat distribution (HIV); CESC cis rs60871478 0.735 rs4721501 chr7:862166 G/T cg15782153 chr7:917662 C7orf20 0.53 5.61 0.33 5.06e-8 Cerebrospinal P-tau181p levels; CESC cis rs9549367 0.713 rs3024747 chr13:113821787 C/G cg18105134 chr13:113819100 PROZ -0.66 -8.35 -0.46 3.82e-15 Platelet distribution width; CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg15383120 chr6:291909 DUSP22 0.66 8.42 0.46 2.34e-15 Menopause (age at onset); CESC cis rs6546537 1.000 rs6727435 chr2:69864236 C/A cg10773587 chr2:69614142 GFPT1 -0.58 -7.09 -0.4 1.25e-11 Serum thyroid-stimulating hormone levels; CESC cis rs1461503 0.932 rs10892934 chr11:122837950 C/T cg27398637 chr11:122830231 C11orf63 -0.57 -8.68 -0.47 4.17e-16 Menarche (age at onset); CESC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg20243544 chr17:37824526 PNMT -0.43 -5.27 -0.31 2.81e-7 Glomerular filtration rate (creatinine); CESC cis rs4319547 1.000 rs6489071 chr12:123025576 C/G cg23029597 chr12:123009494 RSRC2 -0.46 -5.21 -0.3 3.86e-7 Body mass index; CESC cis rs7116495 0.609 rs3750907 chr11:71822560 T/C cg18441811 chr11:71824068 C11orf51 0.83 5.17 0.3 4.55e-7 Severe influenza A (H1N1) infection; CESC cis rs3806843 0.966 rs6891559 chr5:140145206 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.43 -5.61 -0.33 5.03e-8 Depressive symptoms (multi-trait analysis); CESC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg23281280 chr6:28129359 ZNF389 0.49 6.97 0.39 2.57e-11 Depression; CESC cis rs11155671 0.530 rs6933882 chr6:150210802 A/G cg09699651 chr6:150184138 LRP11 0.55 7.7 0.43 2.78e-13 Testicular germ cell tumor; CESC cis rs4595586 0.525 rs17467376 chr12:39377551 T/G cg26384229 chr12:38710491 ALG10B 0.62 8.69 0.47 3.89e-16 Morning vs. evening chronotype; CESC cis rs4604732 0.536 rs12037221 chr1:247631212 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.52 6.44 0.37 5.54e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs11785400 0.793 rs7007891 chr8:143749228 C/T cg10596483 chr8:143751796 JRK -0.42 -5.26 -0.31 3e-7 Schizophrenia; CESC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg18876405 chr7:65276391 NA -0.5 -6.8 -0.39 6.78e-11 Aortic root size; CESC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg02353165 chr6:42928485 GNMT 0.83 13.12 0.63 1.19e-30 Alzheimer's disease in APOE e4+ carriers; CESC cis rs950027 0.620 rs1145077 chr15:45683795 A/C cg21132104 chr15:45694354 SPATA5L1 -0.65 -8.18 -0.45 1.16e-14 Response to fenofibrate (adiponectin levels); CESC trans rs8073060 0.586 rs225278 chr17:33974170 C/T cg19694781 chr19:47549865 TMEM160 -0.73 -7.32 -0.41 3.05e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.66 -10.03 -0.52 2.78e-20 Personality dimensions; CESC trans rs7922314 0.571 rs61282002 chr10:64738038 C/T cg06935979 chr1:232941706 KIAA1383 -0.63 -6.09 -0.35 3.89e-9 Cutaneous psoriasis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11857025 chr1:109633344 TMEM167B -0.45 -6.31 -0.36 1.14e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1801251 1.000 rs12474040 chr2:233615345 T/G cg08000102 chr2:233561755 GIGYF2 0.66 9.46 0.5 1.72e-18 Coronary artery disease; CESC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg02569458 chr12:86230093 RASSF9 0.49 7.21 0.4 5.91e-12 Major depressive disorder; CESC cis rs7264396 0.690 rs2425157 chr20:34419083 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -8.34 -0.46 4.18e-15 Total cholesterol levels; CESC cis rs933688 1.000 rs2839728 chr5:90727412 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 11.74 0.58 6.66e-26 Smoking behavior; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg13451882 chr2:139256702 NA 0.42 6.18 0.35 2.35e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7208859 0.673 rs216418 chr17:28936537 G/A cg17105886 chr17:28927953 LRRC37B2 0.63 5.7 0.33 3.26e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg11843238 chr5:131593191 PDLIM4 0.35 5.16 0.3 4.86e-7 Breast cancer; CESC cis rs6754311 0.509 rs3820794 chr2:136505546 C/T cg07169764 chr2:136633963 MCM6 -0.72 -9.31 -0.5 5.24e-18 Mosquito bite size; CESC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg08859206 chr1:53392774 SCP2 0.56 7.09 0.4 1.21e-11 Monocyte count; CESC cis rs965513 0.901 rs1877431 chr9:100534147 C/T cg13688889 chr9:100608707 NA 0.47 6.47 0.37 4.67e-10 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs8060686 0.641 rs13816 chr16:68055495 G/C cg26727032 chr16:67993705 SLC12A4 -0.52 -6.46 -0.37 4.91e-10 HDL cholesterol;Metabolic syndrome; CESC trans rs1728785 1.000 rs1645935 chr16:68563791 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.42 0.41 1.57e-12 Ulcerative colitis; CESC cis rs7659604 0.967 rs28529384 chr4:122664215 T/C cg19671926 chr4:122722719 EXOSC9 -0.44 -5.18 -0.3 4.35e-7 Type 2 diabetes; CESC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg12463550 chr7:65579703 CRCP -0.54 -6.96 -0.39 2.67e-11 Aortic root size; CESC cis rs12142240 0.698 rs3991877 chr1:46853749 C/A cg00530320 chr1:46809349 NSUN4 0.6 8.3 0.45 5.19e-15 Menopause (age at onset); CESC cis rs72781680 0.846 rs55707417 chr2:24029928 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.7 0.38 1.22e-10 Lymphocyte counts; CESC cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg02935154 chr7:12443704 VWDE -0.59 -6.31 -0.36 1.14e-9 Coronary artery disease; CESC cis rs10197940 0.686 rs12616688 chr2:152242099 C/G cg19508488 chr2:152266495 RIF1 0.61 6.94 0.39 2.99e-11 Lung cancer; CESC cis rs7927771 0.507 rs1483988 chr11:47899030 C/T cg20307385 chr11:47447363 PSMC3 0.61 8.44 0.46 2.09e-15 Subjective well-being; CESC cis rs8103278 1.000 rs35302007 chr19:46219145 G/C cg11657440 chr19:46296263 DMWD -0.54 -6.82 -0.39 6.09e-11 Coronary artery disease; CESC cis rs6951245 0.882 rs11764817 chr7:1064610 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.43 5.12 0.3 6.02e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs523522 0.962 rs11065145 chr12:120947419 A/G cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs7274811 0.681 rs291670 chr20:31945861 G/A cg21523528 chr20:32077966 CBFA2T2 -0.43 -5.18 -0.3 4.39e-7 Height; CESC cis rs9911578 0.935 rs304261 chr17:56813782 A/G cg12560992 chr17:57184187 TRIM37 0.91 14.71 0.67 3.24e-36 Intelligence (multi-trait analysis); CESC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg13607699 chr17:42295918 UBTF 0.7 9.52 0.5 1.15e-18 Total body bone mineral density; CESC cis rs367943 0.712 rs7731465 chr5:112687385 A/G cg12552261 chr5:112820674 MCC -0.41 -5.08 -0.3 7.03e-7 Type 2 diabetes; CESC cis rs7662987 1.000 rs7683802 chr4:99995138 T/G cg13256891 chr4:100009986 ADH5 -0.82 -6.06 -0.35 4.59e-9 Smoking initiation; CESC cis rs2629540 0.847 rs12762597 chr10:126387043 G/A cg08799069 chr10:126477246 METTL10 0.58 7.23 0.41 5.03e-12 Cocaine dependence; CESC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg12463550 chr7:65579703 CRCP -0.5 -6.41 -0.37 6.59e-10 Aortic root size; CESC trans rs116095464 0.558 rs6879656 chr5:264428 T/C cg00938859 chr5:1591904 SDHAP3 0.62 6.05 0.35 5.01e-9 Breast cancer; CESC cis rs7592578 0.639 rs13417431 chr2:191293055 A/G cg27211696 chr2:191398769 TMEM194B -0.56 -5.83 -0.34 1.64e-8 Diastolic blood pressure; CESC cis rs7508679 1.000 rs10410204 chr19:7224350 C/T cg09779027 chr19:7224513 INSR 0.55 8.86 0.48 1.21e-16 Hypothyroidism; CESC cis rs6987853 0.830 rs12542919 chr8:42356035 C/T cg09913449 chr8:42400586 C8orf40 -0.34 -5.3 -0.31 2.41e-7 Mean corpuscular hemoglobin concentration; CESC cis rs6088580 0.634 rs6087577 chr20:32955423 C/T cg08999081 chr20:33150536 PIGU 0.58 9.7 0.51 3.01e-19 Glomerular filtration rate (creatinine); CESC cis rs7727544 0.735 rs273914 chr5:131660431 A/T cg07395648 chr5:131743802 NA -0.48 -6.37 -0.36 8.23e-10 Blood metabolite levels; CESC cis rs79839061 0.610 rs3775130 chr4:875144 G/A cg07828340 chr4:882639 GAK 1.07 8.24 0.45 7.96e-15 Intelligence (multi-trait analysis); CESC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg05861140 chr6:150128134 PCMT1 -0.38 -5.43 -0.32 1.29e-7 Lung cancer; CESC cis rs35520189 0.845 rs13021862 chr2:113641944 G/A cg06156847 chr2:113672199 IL1F7 0.36 5.47 0.32 1.04e-7 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs910316 0.737 rs175043 chr14:75471803 G/A cg11812906 chr14:75593930 NEK9 -0.81 -12.62 -0.61 6.47e-29 Height; CESC cis rs921968 0.541 rs3755042 chr2:219317248 T/C cg02176678 chr2:219576539 TTLL4 -0.53 -9.28 -0.5 6.12e-18 Mean corpuscular hemoglobin concentration; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19850565 chr19:35168394 ZNF302 0.46 6.24 0.36 1.69e-9 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC trans rs637571 0.544 rs617791 chr11:65702523 C/G cg17712092 chr4:129076599 LARP1B 0.68 8.98 0.48 5.29e-17 Eosinophil percentage of white cells; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23352145 chr13:21751331 MRP63;SKA3 0.48 6.55 0.37 3.02e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2180341 0.782 rs6912750 chr6:127723081 A/T cg24812749 chr6:127587940 RNF146 0.83 12.07 0.6 5.14e-27 Breast cancer; CESC cis rs6460942 1.000 rs17191008 chr7:12417690 T/G cg02935154 chr7:12443704 VWDE -0.61 -6.32 -0.36 1.08e-9 Coronary artery disease; CESC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg26354017 chr1:205819088 PM20D1 -0.47 -6.3 -0.36 1.26e-9 Menarche (age at onset); CESC cis rs561341 1.000 rs542132 chr17:30307193 A/T cg00745463 chr17:30367425 LRRC37B -0.78 -7.09 -0.4 1.2e-11 Hip circumference adjusted for BMI; CESC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg11301795 chr4:187892539 NA 0.71 11.36 0.57 1.23e-24 Lobe attachment (rater-scored or self-reported); CESC trans rs116095464 0.558 rs1541822 chr5:269234 A/C cg00938859 chr5:1591904 SDHAP3 -0.64 -7.05 -0.4 1.52e-11 Breast cancer; CESC cis rs9916302 0.904 rs7221875 chr17:37543328 G/A cg07936489 chr17:37558343 FBXL20 0.79 11.47 0.58 5.25e-25 Glomerular filtration rate (creatinine); CESC cis rs2732480 0.500 rs12828309 chr12:48641160 C/T cg04545296 chr12:48745243 ZNF641 0.39 6.71 0.38 1.18e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg15993674 chr20:4667405 PRNP 0.54 6.0 0.35 6.5e-9 Diastolic blood pressure; CESC cis rs2228479 0.850 rs62054611 chr16:89817017 T/C cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs4268898 0.662 rs714531 chr2:24399877 G/A cg08917208 chr2:24149416 ATAD2B 0.62 5.7 0.33 3.21e-8 Asthma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19065773 chr10:98469552 PIK3AP1 -0.4 -6.12 -0.35 3.4e-9 Gut microbiota (bacterial taxa); CESC cis rs9611565 0.592 rs1811113 chr22:42073134 C/T cg06634786 chr22:41940651 POLR3H 0.62 6.25 0.36 1.67e-9 Vitiligo; CESC cis rs72781680 1.000 rs7594510 chr2:24173377 A/G cg20701182 chr2:24300061 SF3B14 0.64 5.74 0.33 2.63e-8 Lymphocyte counts; CESC cis rs1267303 0.562 rs2476162 chr1:47007324 G/A cg25110126 chr1:46999211 NA 0.76 9.07 0.49 2.66e-17 Monobrow; CESC cis rs12477438 0.765 rs13390672 chr2:99589829 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs34779708 0.733 rs59287215 chr10:35543994 C/T cg03585969 chr10:35415529 CREM 0.56 6.54 0.37 3.22e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs4268898 0.571 rs1986478 chr2:24468545 G/A cg20701182 chr2:24300061 SF3B14 0.63 6.84 0.39 5.33e-11 Asthma; CESC cis rs2070997 0.756 rs3824400 chr9:133734075 A/G cg11464064 chr9:133710261 ABL1 -0.55 -6.04 -0.35 5.13e-9 Response to amphetamines; CESC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg07157834 chr1:205819609 PM20D1 -0.64 -8.49 -0.46 1.51e-15 Menarche (age at onset); CESC cis rs7666738 0.830 rs11947578 chr4:98930462 T/G cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg01516881 chr6:292596 DUSP22 -0.84 -11.66 -0.58 1.27e-25 Menopause (age at onset); CESC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.82 0.34 1.71e-8 Tonsillectomy; CESC cis rs1538970 0.816 rs10789464 chr1:45959102 C/T cg05343316 chr1:45956843 TESK2 0.93 12.71 0.62 3.33e-29 Platelet count; CESC cis rs12121840 0.790 rs7535829 chr1:165518876 C/A cg16553119 chr1:165599451 MGST3 -0.46 -5.22 -0.31 3.69e-7 Interleukin-1-receptor antagonist levels; CESC cis rs116095464 0.558 rs10057299 chr5:242135 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.27 0.31 2.9e-7 Breast cancer; CESC cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg23711669 chr6:146136114 FBXO30 0.84 10.91 0.56 3.89e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs3106136 0.967 rs282449 chr4:95141228 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.01 -0.4 1.94e-11 Capecitabine sensitivity; CESC cis rs10129255 0.500 rs10131875 chr14:107201036 T/C cg23076370 chr14:107095027 NA -0.64 -9.33 -0.5 4.36e-18 Kawasaki disease; CESC cis rs11792861 0.816 rs2275637 chr9:111696043 C/G cg05043794 chr9:111880884 C9orf5 -0.37 -6.05 -0.35 5e-9 Menarche (age at onset); CESC cis rs7129220 0.512 rs16907504 chr11:10169531 C/G cg01453529 chr11:10209919 SBF2 -0.43 -5.07 -0.3 7.32e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs60843830 1.000 rs2290911 chr2:224919 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.78 9.89 0.52 7.58e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs698833 0.859 rs1302175 chr2:44657024 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.47 5.98 0.34 7.17e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg26314531 chr2:26401878 FAM59B -0.85 -8.88 -0.48 1e-16 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26270411 chr20:43514327 YWHAB 0.65 7.93 0.44 6.31e-14 Gut microbiome composition (summer); CESC cis rs2180341 0.960 rs7766802 chr6:127709871 T/G cg24812749 chr6:127587940 RNF146 1.02 13.91 0.65 2.08e-33 Breast cancer; CESC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg07936489 chr17:37558343 FBXL20 0.77 10.91 0.56 4.02e-23 Glomerular filtration rate (creatinine); CESC cis rs10492096 1.000 rs10849462 chr12:6575992 C/T cg13857086 chr12:6580257 VAMP1 0.64 6.31 0.36 1.18e-9 Hip geometry; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05095230 chr13:50367060 KPNA3 0.51 7.0 0.4 2.08e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12220238 1.000 rs11000901 chr10:75919971 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.65 6.16 0.35 2.66e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs1144333 1.000 rs1340684 chr1:76471146 T/C cg22875332 chr1:76189707 ACADM 0.54 5.16 0.3 4.8e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs1372520 0.684 rs1837891 chr4:90736131 C/G cg15133208 chr4:90757351 SNCA 0.41 5.61 0.33 5.17e-8 Neuroticism; CESC trans rs4374383 0.631 rs10175316 chr2:112669874 A/G cg12127991 chr1:228870637 RHOU 0.4 6.07 0.35 4.35e-9 Hepatitis C induced liver fibrosis; CESC cis rs78456975 1.000 rs13413356 chr2:1553849 G/T cg01028140 chr2:1542097 TPO -0.51 -5.44 -0.32 1.24e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs965469 0.779 rs57373308 chr20:3314715 G/C cg25506879 chr20:3388711 C20orf194 -0.47 -5.13 -0.3 5.51e-7 IFN-related cytopenia; CESC trans rs1945213 0.694 rs7122627 chr11:55862565 A/G cg03929089 chr4:120376271 NA 0.77 7.35 0.41 2.48e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.97 0.48 5.67e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs10129255 0.518 rs2006284 chr14:107132201 G/A cg07958169 chr14:107095056 NA -0.54 -8.81 -0.48 1.67e-16 Kawasaki disease; CESC cis rs911555 0.755 rs10148970 chr14:103892000 G/A cg09975044 chr14:104007538 NA 0.45 5.63 0.33 4.63e-8 Intelligence (multi-trait analysis); CESC cis rs4711336 1.000 rs764752 chr6:33658066 G/C cg14003231 chr6:33640908 ITPR3 0.32 5.46 0.32 1.07e-7 Height; CESC cis rs965513 1.000 rs10983701 chr9:100537577 G/A cg13688889 chr9:100608707 NA -0.61 -8.64 -0.47 5.56e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs3008870 0.583 rs11208985 chr1:67464666 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -11.11 -0.56 8.58e-24 Lymphocyte percentage of white cells; CESC cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4835473 0.932 rs4308330 chr4:144695914 A/G cg25736465 chr4:144833511 NA -0.33 -5.18 -0.3 4.39e-7 Immature fraction of reticulocytes; CESC cis rs6690583 0.623 rs1371142 chr1:85455373 A/T cg22153463 chr1:85462885 MCOLN2 0.72 7.18 0.4 7.13e-12 Serum sulfate level; CESC cis rs8177179 0.666 rs4075352 chr3:133468012 A/G cg24879335 chr3:133465180 TF 0.31 5.37 0.31 1.75e-7 Iron status biomarkers (transferrin levels); CESC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg23034840 chr1:205782522 SLC41A1 -0.58 -6.31 -0.36 1.19e-9 Menarche (age at onset); CESC cis rs8070128 0.601 rs8080602 chr17:17954728 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.5 -6.33 -0.36 1.03e-9 Total body bone mineral density; CESC cis rs7714584 1.000 rs7709388 chr5:150246539 C/G cg22134413 chr5:150180641 NA 0.5 5.76 0.33 2.3e-8 Crohn's disease; CESC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.12 -0.3 5.87e-7 Life satisfaction; CESC cis rs9304742 0.962 rs1044467 chr19:53452769 A/G cg09915433 chr19:53449742 NA -0.38 -5.13 -0.3 5.48e-7 Psoriasis; CESC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.72 6.91 0.39 3.57e-11 Lung function (FEV1/FVC); CESC cis rs77741769 0.549 rs57697145 chr12:121333552 T/G cg02419362 chr12:121203948 SPPL3 0.35 5.6 0.33 5.33e-8 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04228553 chr3:15247818 DVWA;CAPN7 0.63 7.65 0.43 3.71e-13 Gut microbiome composition (summer); CESC cis rs2279817 0.735 rs71644063 chr1:17987274 A/G cg21791023 chr1:18019539 ARHGEF10L -0.66 -8.06 -0.44 2.67e-14 Neuroticism; CESC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg10691866 chr7:65817282 TPST1 -0.33 -5.43 -0.32 1.3e-7 Aortic root size; CESC cis rs6460942 0.732 rs73677576 chr7:12286535 G/A cg20607287 chr7:12443886 VWDE -0.59 -6.43 -0.37 5.83e-10 Coronary artery disease; CESC cis rs897984 0.770 rs3813020 chr16:30934075 G/A cg00531865 chr16:30841666 NA 0.51 7.12 0.4 1.01e-11 Dementia with Lewy bodies; CESC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.61 7.86 0.43 9.58e-14 Prudent dietary pattern; CESC cis rs728616 0.558 rs12414691 chr10:82156982 A/T cg05935833 chr10:81318306 SFTPA2 -0.46 -5.67 -0.33 3.63e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs67311347 1.000 rs66841330 chr3:40531123 G/A cg24209194 chr3:40518798 ZNF619 0.47 5.76 0.33 2.36e-8 Renal cell carcinoma; CESC cis rs6582630 0.576 rs2387836 chr12:38560070 A/G cg26384229 chr12:38710491 ALG10B 0.43 5.7 0.33 3.26e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs17376456 0.935 rs13156002 chr5:93508931 G/A cg21475434 chr5:93447410 FAM172A 0.88 7.77 0.43 1.71e-13 Diabetic retinopathy; CESC cis rs7917772 0.582 rs4917976 chr10:104360518 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.4 -5.54 -0.32 7.23e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2645694 0.603 rs2703123 chr4:77821154 C/T cg10057126 chr4:77819792 ANKRD56 0.59 8.61 0.47 6.84e-16 Emphysema distribution in smoking; CESC cis rs870825 0.616 rs7678616 chr4:185648714 T/G cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs4629180 1.000 rs908133 chr2:102092374 A/C cg01388757 chr2:102091195 RFX8 -0.38 -5.86 -0.34 1.37e-8 Chronic rhinosinusitis with nasal polyps; CESC cis rs938554 0.806 rs4447862 chr4:9931645 C/G cg00071950 chr4:10020882 SLC2A9 -0.44 -5.96 -0.34 8.01e-9 Blood metabolite levels; CESC cis rs9660992 0.736 rs55673946 chr1:205250475 T/C cg21643547 chr1:205240462 TMCC2 -0.48 -7.1 -0.4 1.15e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs910316 1.000 rs9805979 chr14:75566209 G/A cg08847533 chr14:75593920 NEK9 0.99 18.74 0.75 1.84e-50 Height; CESC cis rs34779708 0.898 rs11595898 chr10:35326263 T/C cg04310649 chr10:35416472 CREM -0.48 -5.8 -0.34 1.85e-8 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01172785 chr16:50092553 NA -0.76 -8.52 -0.46 1.25e-15 Gut microbiome composition (summer); CESC cis rs36096196 0.891 rs12082516 chr1:2251160 C/T cg17974515 chr1:2252516 NA -0.45 -7.85 -0.43 1e-13 Coronary artery disease; CESC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg24562669 chr7:97807699 LMTK2 0.51 7.35 0.41 2.45e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs4268898 1.000 rs1203 chr2:24443330 A/G cg20701182 chr2:24300061 SF3B14 -0.43 -5.23 -0.31 3.4e-7 Asthma; CESC trans rs875971 0.638 rs801205 chr7:66022144 C/A cg26939375 chr7:64535504 NA -0.64 -8.7 -0.47 3.62e-16 Aortic root size; CESC cis rs258892 0.895 rs57787613 chr5:72047278 C/A cg21869765 chr5:72125136 TNPO1 -0.4 -5.13 -0.3 5.56e-7 Small cell lung carcinoma; CESC cis rs1005277 0.522 rs289645 chr10:37943642 T/C cg00409905 chr10:38381863 ZNF37A -0.48 -6.54 -0.37 3.13e-10 Extrinsic epigenetic age acceleration; CESC cis rs6502050 0.604 rs9897355 chr17:80078095 G/A cg23985595 chr17:80112537 CCDC57 0.41 6.54 0.37 3.19e-10 Life satisfaction; CESC trans rs7944735 1.000 rs7944735 chr11:47955608 G/C cg15704280 chr7:45808275 SEPT13 0.61 6.36 0.36 8.65e-10 Intraocular pressure; CESC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6e-10 Life satisfaction; CESC trans rs459571 0.920 rs455073 chr9:136909141 G/C cg09836344 chr4:1243392 C4orf42;CTBP1 -0.65 -8.58 -0.47 8.08e-16 Platelet distribution width; CESC cis rs854765 0.583 rs8075965 chr17:17853180 A/T cg16928487 chr17:17741425 SREBF1 -0.57 -9.58 -0.51 7.39e-19 Total body bone mineral density; CESC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg08392591 chr16:89556376 ANKRD11 -0.52 -7.05 -0.4 1.56e-11 Multiple myeloma (IgH translocation); CESC cis rs7429990 0.930 rs13075457 chr3:48054553 A/G cg11946769 chr3:48343235 NME6 -0.43 -5.18 -0.3 4.46e-7 Educational attainment (years of education); CESC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg26441486 chr22:50317300 CRELD2 0.42 5.28 0.31 2.66e-7 Schizophrenia; CESC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg06481639 chr22:41940642 POLR3H 0.6 5.97 0.34 7.49e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg15445000 chr17:37608096 MED1 0.4 6.6 0.38 2.19e-10 Glomerular filtration rate (creatinine); CESC cis rs8070624 0.543 rs8068175 chr17:17874486 C/T cg04398451 chr17:18023971 MYO15A -0.69 -9.51 -0.5 1.19e-18 Total body bone mineral density; CESC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg04398451 chr17:18023971 MYO15A 0.57 7.71 0.43 2.58e-13 Total body bone mineral density; CESC cis rs7264396 0.790 rs761825 chr20:34194054 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.29 -0.45 5.67e-15 Total cholesterol levels; CESC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg14893161 chr1:205819251 PM20D1 0.43 5.99 0.35 6.82e-9 Prostate-specific antigen levels; CESC cis rs2777491 0.957 rs6493002 chr15:41709195 C/G cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.87 -0.52 8.9e-20 Ulcerative colitis; CESC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg18876405 chr7:65276391 NA -0.5 -6.92 -0.39 3.36e-11 Aortic root size; CESC cis rs2073300 0.609 rs17830281 chr20:23350525 C/T cg16736954 chr20:23401023 NAPB 0.77 5.74 0.33 2.6e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs116095464 0.558 rs10055405 chr5:265666 C/T cg00938859 chr5:1591904 SDHAP3 0.64 6.9 0.39 3.8e-11 Breast cancer; CESC cis rs9467711 0.659 rs35304979 chr6:26356347 C/A cg14345882 chr6:26364793 BTN3A2 0.59 6.06 0.35 4.66e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2635047 0.615 rs2571007 chr18:44645610 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.43 -5.4 -0.31 1.5e-7 Educational attainment; CESC cis rs75920871 0.562 rs68137714 chr11:117025357 A/G cg01368799 chr11:117014884 PAFAH1B2 -0.57 -5.14 -0.3 5.26e-7 Subjective well-being; CESC cis rs67478160 0.634 rs1955660 chr14:104229985 C/T cg01849466 chr14:104193079 ZFYVE21 -0.52 -7.56 -0.42 6.69e-13 Schizophrenia; CESC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs61931739 0.534 rs11053073 chr12:34202412 C/T cg19457237 chr12:34500585 NA -0.38 -5.33 -0.31 2.12e-7 Morning vs. evening chronotype; CESC cis rs7824557 0.564 rs2736288 chr8:11228100 G/A cg21775007 chr8:11205619 TDH -0.53 -7.78 -0.43 1.63e-13 Retinal vascular caliber; CESC cis rs909002 0.772 rs6681414 chr1:32070234 G/A cg13919466 chr1:32135498 COL16A1 -0.47 -8.6 -0.47 6.88e-16 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg12963246 chr6:28129442 ZNF389 0.57 7.67 0.43 3.36e-13 Depression; CESC cis rs2742234 0.541 rs60845448 chr10:43721462 C/T cg15436174 chr10:43711423 RASGEF1A 0.47 5.58 0.32 5.81e-8 Hirschsprung disease; CESC cis rs2625529 0.526 rs8031386 chr15:72508799 C/A cg16672083 chr15:72433130 SENP8 -0.44 -6.1 -0.35 3.76e-9 Red blood cell count; CESC cis rs1707322 0.721 rs10890343 chr1:46157922 C/T cg03146154 chr1:46216737 IPP 0.77 10.66 0.55 2.5e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1814175 0.754 rs10839453 chr11:49955815 A/T cg03929089 chr4:120376271 NA -0.93 -16.29 -0.71 8.13e-42 Height; CESC cis rs1443512 0.812 rs1975470 chr12:54336841 G/A cg12374095 chr12:54320830 NA -0.46 -6.37 -0.36 8.26e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs2425143 1.000 rs11907811 chr20:34428078 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -6.78 -0.38 7.94e-11 Blood protein levels; CESC cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC cis rs9457247 0.602 rs12209395 chr6:167463914 C/T cg23791538 chr6:167370224 RNASET2 -0.49 -6.39 -0.37 7.62e-10 Crohn's disease; CESC cis rs9309473 1.000 rs7604682 chr2:73788026 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.37 -0.36 8.47e-10 Metabolite levels; CESC cis rs1511802 0.579 rs7682918 chr4:187115841 C/T cg24794857 chr4:187113578 CYP4V2 0.42 5.42 0.32 1.36e-7 Blood protein levels; CESC cis rs367943 1.000 rs367943 chr5:112809728 C/T cg12552261 chr5:112820674 MCC 0.6 7.35 0.41 2.42e-12 Type 2 diabetes; CESC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.47 6.07 0.35 4.52e-9 Total body bone mineral density; CESC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.49 -5.2 -0.3 4.06e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg22535103 chr8:58192502 C8orf71 -0.67 -7.23 -0.41 5.31e-12 Developmental language disorder (linguistic errors); CESC cis rs1707322 1.000 rs10890378 chr1:46410657 A/G cg05343316 chr1:45956843 TESK2 -0.44 -5.42 -0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9926296 0.632 rs7206546 chr16:89799079 C/T cg04287289 chr16:89883240 FANCA -0.65 -8.72 -0.47 3.11e-16 Vitiligo; CESC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg16743903 chr16:89593216 SPG7 -0.41 -5.23 -0.31 3.4e-7 Multiple myeloma (IgH translocation); CESC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg21724239 chr8:58056113 NA 0.6 5.55 0.32 6.93e-8 Developmental language disorder (linguistic errors); CESC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg07507251 chr3:52567010 NT5DC2 -0.37 -6.44 -0.37 5.55e-10 Electroencephalogram traits; CESC cis rs4423214 1.000 rs1044482 chr11:71155171 C/T cg24826892 chr11:71159390 DHCR7 0.49 5.84 0.34 1.49e-8 Vitamin D levels; CESC cis rs73195822 0.773 rs10849903 chr12:111112319 T/C cg12870014 chr12:110450643 ANKRD13A 0.76 7.62 0.42 4.46e-13 Itch intensity from mosquito bite; CESC cis rs34779708 0.966 rs4934537 chr10:35441512 C/T cg04310649 chr10:35416472 CREM -0.51 -6.21 -0.36 2.08e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7917772 0.636 rs2863718 chr10:104519631 G/C cg04362960 chr10:104952993 NT5C2 0.46 5.24 0.31 3.21e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg18769074 chr3:133464867 TF 0.29 5.12 0.3 6.02e-7 Iron status biomarkers; CESC cis rs10129255 0.518 rs8009594 chr14:107185733 G/T cg23076370 chr14:107095027 NA -0.67 -10.02 -0.52 3.08e-20 Kawasaki disease; CESC cis rs1413885 0.502 rs7545397 chr1:65856282 C/A cg14976592 chr1:65886160 LEPROT;LEPR 0.49 6.41 0.37 6.53e-10 Anticoagulant levels; CESC cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg26116260 chr4:7069785 GRPEL1 0.74 8.82 0.48 1.54e-16 Monocyte percentage of white cells; CESC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.84 -11.53 -0.58 3.5e-25 Alzheimer's disease; CESC trans rs1814175 0.565 rs4881721 chr11:49761851 G/A cg15704280 chr7:45808275 SEPT13 -0.81 -11.18 -0.57 4.85e-24 Height; CESC cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg22535103 chr8:58192502 C8orf71 0.86 9.66 0.51 4.12e-19 Developmental language disorder (linguistic errors); CESC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg06577658 chr19:46296270 DMWD 0.43 5.27 0.31 2.77e-7 Coronary artery disease; CESC cis rs2066819 1.000 rs2306693 chr12:56680531 T/C cg26734620 chr12:56694298 CS 1.07 6.58 0.37 2.56e-10 Psoriasis vulgaris; CESC cis rs9910055 0.530 rs2269908 chr17:42294198 G/C cg19774624 chr17:42201019 HDAC5 -0.59 -8.54 -0.46 1.04e-15 Total body bone mineral density; CESC cis rs2243480 1.000 rs10247526 chr7:65780696 T/G cg13147721 chr7:65941812 NA 0.97 9.19 0.49 1.21e-17 Diabetic kidney disease; CESC cis rs453301 0.686 rs7814328 chr8:8876229 T/C cg15556689 chr8:8085844 FLJ10661 -0.47 -5.72 -0.33 2.93e-8 Joint mobility (Beighton score); CESC cis rs9325144 0.647 rs1386018 chr12:39104360 C/T cg26384229 chr12:38710491 ALG10B -0.5 -7.06 -0.4 1.47e-11 Morning vs. evening chronotype; CESC cis rs9858542 1.000 rs1131095 chr3:49714225 T/C cg07274523 chr3:49395745 GPX1 0.66 8.53 0.46 1.13e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg01100864 chr12:122750645 VPS33A 0.45 6.23 0.36 1.8e-9 Systemic lupus erythematosus; CESC cis rs3784262 0.935 rs4646563 chr15:58353335 T/C cg12031962 chr15:58353849 ALDH1A2 -0.33 -5.37 -0.31 1.76e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg06221963 chr1:154839813 KCNN3 -0.67 -11.38 -0.57 1.05e-24 Prostate cancer; CESC cis rs2228479 0.850 rs11644804 chr16:89976224 G/A cg00800038 chr16:89945340 TCF25 -0.79 -7.7 -0.43 2.8e-13 Skin colour saturation; CESC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg11663144 chr21:46675770 NA -0.64 -10.02 -0.52 2.95e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9309473 0.898 rs6546852 chr2:73833431 G/A cg20560298 chr2:73613845 ALMS1 -0.45 -6.03 -0.35 5.44e-9 Metabolite levels; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07115558 chr19:3029503 TLE2 -0.48 -6.12 -0.35 3.41e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg02487422 chr3:49467188 NICN1 -0.52 -7.55 -0.42 6.85e-13 Resting heart rate; CESC cis rs4835473 0.864 rs17018131 chr4:144658800 G/T cg25736465 chr4:144833511 NA -0.34 -5.3 -0.31 2.46e-7 Immature fraction of reticulocytes; CESC cis rs9611565 0.532 rs4401299 chr22:42156517 A/G cg06634786 chr22:41940651 POLR3H 0.5 5.61 0.33 5.08e-8 Vitiligo; CESC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg22823121 chr1:150693482 HORMAD1 0.46 6.49 0.37 4.22e-10 Melanoma; CESC cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg11890956 chr21:40555474 PSMG1 0.67 9.32 0.5 4.7e-18 Cognitive function; CESC cis rs12725198 1.000 rs12725694 chr1:16080501 G/A cg18133145 chr1:16060689 PLEKHM2 -0.52 -5.66 -0.33 4e-8 Cardiac Troponin-T levels; CESC cis rs1545257 0.505 rs958352 chr2:24634240 A/G cg06627628 chr2:24431161 ITSN2 -0.47 -5.72 -0.33 2.84e-8 Sjögren's syndrome; CESC cis rs55871839 0.708 rs13261666 chr8:59814666 G/T cg07426533 chr8:59803705 TOX -0.51 -7.41 -0.41 1.71e-12 Pneumonia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05842370 chr22:41682224 RANGAP1 0.61 7.15 0.4 8.47e-12 Gut microbiome composition (summer); CESC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg03609598 chr5:56110824 MAP3K1 -0.53 -5.57 -0.32 6.1e-8 Initial pursuit acceleration; CESC cis rs7143963 0.580 rs6575931 chr14:103301574 A/G cg24154132 chr14:103367632 TRAF3 0.31 5.64 0.33 4.28e-8 Body mass index; CESC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg23758822 chr17:41437982 NA 1.05 16.24 0.71 1.24e-41 Menopause (age at onset); CESC cis rs35955747 0.869 rs5753576 chr22:31757735 C/T cg25791279 chr22:32026902 PISD 0.48 5.97 0.34 7.59e-9 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs9487051 0.768 rs398944 chr6:109523444 T/G cg01475377 chr6:109611718 NA -0.46 -6.95 -0.39 2.75e-11 Reticulocyte fraction of red cells; CESC cis rs17376456 0.877 rs10476526 chr5:93461916 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.44 0.32 1.23e-7 Diabetic retinopathy; CESC cis rs7223966 1.000 rs8067431 chr17:61817048 T/C cg11494091 chr17:61959527 GH2 0.4 5.31 0.31 2.3e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7258465 1.000 rs8103622 chr19:18572834 C/T cg25828334 chr19:18545568 ISYNA1 -0.33 -5.34 -0.31 2.04e-7 Breast cancer; CESC cis rs12410462 0.681 rs4614224 chr1:227574966 C/T cg23173402 chr1:227635558 NA 0.68 5.71 0.33 2.96e-8 Major depressive disorder; CESC cis rs1983891 0.673 rs912883 chr6:41552040 T/C cg20194872 chr6:41519635 FOXP4 0.46 6.54 0.37 3.14e-10 Prostate cancer; CESC cis rs7474896 0.583 rs1208770 chr10:38044683 C/T cg25427524 chr10:38739819 LOC399744 -0.48 -5.26 -0.31 3.05e-7 Obesity (extreme); CESC cis rs9291683 0.632 rs11734786 chr4:10041499 A/C cg11266682 chr4:10021025 SLC2A9 0.67 13.02 0.62 2.72e-30 Bone mineral density; CESC cis rs11098499 0.599 rs3864142 chr4:120266191 A/T cg09307838 chr4:120376055 NA 0.75 9.66 0.51 4.11e-19 Corneal astigmatism; CESC cis rs12497850 0.931 rs7431710 chr3:48935583 G/A cg06212747 chr3:49208901 KLHDC8B 0.66 9.13 0.49 1.8e-17 Parkinson's disease; CESC cis rs7301826 1.000 rs10773822 chr12:131289107 C/G cg11011512 chr12:131303247 STX2 0.4 5.08 0.3 7.16e-7 Plasma plasminogen activator levels; CESC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg13628971 chr7:2884303 GNA12 0.64 8.03 0.44 3.22e-14 Height; CESC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg12963246 chr6:28129442 ZNF389 0.55 7.35 0.41 2.46e-12 Depression; CESC trans rs11818084 0.664 rs12573789 chr10:126002644 A/G cg19462022 chr13:114810756 RASA3 0.37 6.02 0.35 5.73e-9 Clozapine-induced cytotoxicity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22708233 chr11:47198576 ARFGAP2 0.62 7.48 0.42 1.11e-12 Gut microbiome composition (summer); CESC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.52 -0.32 8.02e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs4604732 0.588 rs12045675 chr1:247623915 C/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.05 0.4 1.54e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg04414720 chr1:150670196 GOLPH3L 0.62 8.85 0.48 1.24e-16 Tonsillectomy; CESC cis rs727505 1.000 rs7806680 chr7:124433079 G/A cg23710748 chr7:124431027 NA -0.39 -6.5 -0.37 4.07e-10 Lewy body disease; CESC cis rs2637266 0.703 rs846643 chr10:78516889 T/G cg18941641 chr10:78392320 NA 0.39 7.46 0.42 1.25e-12 Pulmonary function; CESC cis rs9457247 0.967 rs430145 chr6:167410369 C/T cg23791538 chr6:167370224 RNASET2 -0.61 -8.81 -0.48 1.71e-16 Crohn's disease; CESC cis rs9462846 0.919 rs12202901 chr6:42828550 A/T cg05552183 chr6:42928497 GNMT 0.43 5.11 0.3 6.07e-7 Blood protein levels; CESC trans rs12310956 0.532 rs11052948 chr12:33981973 T/C cg26384229 chr12:38710491 ALG10B 0.6 8.23 0.45 8.51e-15 Morning vs. evening chronotype; CESC cis rs7219021 0.892 rs66866087 chr17:46849323 C/T cg16584676 chr17:46985605 UBE2Z -0.52 -5.91 -0.34 1.04e-8 Schizophrenia or bipolar disorder; CESC cis rs4595586 0.545 rs12811619 chr12:39392196 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC trans rs9929218 0.508 rs6499194 chr16:68744100 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.9 14.6 0.67 8.11e-36 Colorectal cancer; CESC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg10053473 chr17:62856997 LRRC37A3 -0.73 -8.1 -0.45 2.06e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21944557 chr1:179923876 CEP350 -0.49 -6.42 -0.37 6.16e-10 Ulcerative colitis; CESC cis rs9796 0.689 rs13329537 chr15:41449211 C/G cg12426344 chr15:41135900 SPINT1 0.23 5.04 0.3 8.65e-7 Menopause (age at onset); CESC cis rs1499972 0.715 rs1463403 chr3:117623116 C/T cg07612923 chr3:117604196 NA -0.45 -5.09 -0.3 6.95e-7 Schizophrenia; CESC cis rs7727544 0.735 rs272860 chr5:131684175 C/G cg07395648 chr5:131743802 NA -0.43 -5.68 -0.33 3.56e-8 Blood metabolite levels; CESC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg17724175 chr1:150552817 MCL1 0.38 5.85 0.34 1.42e-8 Melanoma; CESC trans rs116095464 0.558 rs6555055 chr5:226160 A/C cg00938859 chr5:1591904 SDHAP3 0.61 6.84 0.39 5.52e-11 Breast cancer; CESC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg06873352 chr17:61820015 STRADA 0.72 12.76 0.62 2.21e-29 Prudent dietary pattern; CESC cis rs34375054 0.526 rs2343638 chr12:125677122 G/C cg25124228 chr12:125621409 AACS -0.5 -5.84 -0.34 1.49e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.39 6.26 0.36 1.53e-9 Personality dimensions; CESC cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg08392591 chr16:89556376 ANKRD11 0.41 5.37 0.31 1.71e-7 Multiple myeloma (IgH translocation); CESC cis rs868036 1.000 rs4776376 chr15:68093435 G/A cg08079166 chr15:68083412 MAP2K5 0.44 6.94 0.39 2.94e-11 Restless legs syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26618056 chr16:25043323 NA 0.62 7.11 0.4 1.06e-11 Gut microbiome composition (summer); CESC cis rs35096708 1.000 rs35096708 chr16:89887249 G/A cg27130406 chr16:89901659 SPIRE2 -0.4 -5.19 -0.3 4.29e-7 Skin aging (microtopography measurement); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg14443380 chr15:74725882 SEMA7A -0.43 -6.54 -0.37 3.19e-10 Vertical cup-disc ratio; CESC cis rs10129255 0.785 rs10150044 chr14:107183934 T/A cg07958169 chr14:107095056 NA -0.41 -5.79 -0.33 2.01e-8 Kawasaki disease; CESC cis rs6831352 0.589 rs1133483 chr4:100023923 G/C cg12011299 chr4:100065546 ADH4 0.72 10.96 0.56 2.76e-23 Alcohol dependence; CESC cis rs3741151 1.000 rs79078097 chr11:73049771 G/A cg17517138 chr11:73019481 ARHGEF17 0.69 5.46 0.32 1.07e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.82 8.2 0.45 1.06e-14 Platelet count; CESC cis rs1395 0.677 rs113353646 chr2:27492674 C/T cg22903471 chr2:27725779 GCKR -0.45 -5.46 -0.32 1.11e-7 Blood metabolite levels; CESC cis rs7927771 0.929 rs12787646 chr11:47669665 T/C cg20307385 chr11:47447363 PSMC3 -0.51 -6.28 -0.36 1.35e-9 Subjective well-being; CESC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.69 6.31 0.36 1.14e-9 Platelet count; CESC cis rs7267979 0.966 rs6037097 chr20:25347221 C/T cg08601574 chr20:25228251 PYGB 0.38 5.47 0.32 1.05e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7000551 0.751 rs2443494 chr8:22372262 C/G cg12081754 chr8:22256438 SLC39A14 0.42 5.63 0.33 4.69e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs3936840 0.539 rs11850701 chr14:102983857 G/A cg18135206 chr14:102964638 TECPR2 0.44 5.63 0.33 4.67e-8 Plateletcrit; CESC cis rs7089973 0.604 rs7919649 chr10:116609576 T/C cg25233709 chr10:116636983 FAM160B1 0.37 5.92 0.34 9.85e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs55883249 1.000 rs62119391 chr2:9712272 A/G cg23886495 chr2:9695866 ADAM17 0.59 5.52 0.32 7.91e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs61542988 0.532 rs12673996 chr7:22833400 C/T cg11367502 chr7:22862612 TOMM7 0.46 5.71 0.33 3.08e-8 Fibrinogen levels; CESC cis rs57083693 0.551 rs10860709 chr12:101723363 G/T cg22051763 chr12:101673672 UTP20 -0.49 -6.06 -0.35 4.55e-9 Alcohol dependence (age at onset); CESC cis rs763121 0.853 rs3747172 chr22:39067524 A/G cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs919433 0.927 rs13032495 chr2:198189346 C/T cg03934865 chr2:198174659 NA -0.49 -7.07 -0.4 1.34e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9303401 0.659 rs62081314 chr17:56778328 A/G cg02118635 chr17:56770003 RAD51C;TEX14 1.03 12.82 0.62 1.31e-29 Cognitive test performance; CESC cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg17143192 chr8:8559678 CLDN23 0.78 8.81 0.48 1.63e-16 Obesity-related traits; CESC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.56 0.47 9.4e-16 Bipolar disorder; CESC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg08470875 chr2:26401718 FAM59B -0.46 -5.14 -0.3 5.45e-7 Gut microbiome composition (summer); CESC cis rs1062177 1.000 rs72802204 chr5:151183183 T/C cg12924095 chr5:151150029 G3BP1 0.49 6.5 0.37 3.86e-10 Preschool internalizing problems; CESC cis rs3820928 0.874 rs3752895 chr2:227886773 A/G cg05526886 chr2:227700861 RHBDD1 -0.44 -5.7 -0.33 3.24e-8 Pulmonary function; CESC trans rs9296661 0.522 rs1326587 chr6:51673684 C/T cg15101985 chr10:85961501 PCDH21 -0.49 -6.09 -0.35 3.86e-9 Weight loss (gastric bypass surgery); CESC cis rs3768617 0.510 rs2296294 chr1:183095596 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg18337363 chr3:52569053 NT5DC2 0.29 5.08 0.3 7.02e-7 Bipolar disorder; CESC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg26408565 chr15:76604113 ETFA -0.4 -5.86 -0.34 1.39e-8 Blood metabolite levels; CESC cis rs4835473 0.864 rs13135472 chr4:144910618 T/C cg25736465 chr4:144833511 NA 0.42 6.43 0.37 6.02e-10 Immature fraction of reticulocytes; CESC cis rs10089 0.909 rs7732599 chr5:127370421 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 9.55 0.51 8.83e-19 Ileal carcinoids; CESC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg24829409 chr8:58192753 C8orf71 -0.61 -6.7 -0.38 1.24e-10 Developmental language disorder (linguistic errors); CESC cis rs561341 0.941 rs2428341 chr17:30317295 C/T cg19193384 chr17:30244184 NA -0.53 -6.19 -0.36 2.23e-9 Hip circumference adjusted for BMI; CESC cis rs66573146 0.656 rs111560662 chr4:6952766 C/T cg26116260 chr4:7069785 GRPEL1 -0.83 -5.2 -0.3 3.95e-7 Granulocyte percentage of myeloid white cells; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16011583 chr17:59489182 C17orf82 -0.57 -7.39 -0.41 1.91e-12 Ulcerative colitis; CESC cis rs10489525 0.556 rs11102882 chr1:115612222 T/A cg01522456 chr1:115632236 TSPAN2 0.39 5.11 0.3 6.3e-7 Autism; CESC cis rs17001868 0.568 rs9611311 chr22:40733951 T/C cg07138101 chr22:40742427 ADSL 0.54 5.18 0.3 4.49e-7 Mammographic density (dense area); CESC cis rs4568518 0.619 rs4470902 chr7:18008310 A/G cg03009463 chr7:17980271 SNX13 -0.42 -5.59 -0.32 5.65e-8 Measles; CESC cis rs6570726 0.967 rs441364 chr6:145853662 G/C cg23711669 chr6:146136114 FBXO30 0.75 10.73 0.55 1.55e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.780 rs12504773 chr4:120562149 G/C cg24375607 chr4:120327624 NA 0.43 5.29 0.31 2.58e-7 Corneal astigmatism; CESC cis rs1983891 1.000 rs913074 chr6:41538545 T/C cg20194872 chr6:41519635 FOXP4 0.51 6.95 0.39 2.87e-11 Prostate cancer; CESC trans rs11098499 0.818 rs7688802 chr4:120451668 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.62 0.51 5.47e-19 Corneal astigmatism; CESC cis rs4268898 1.000 rs1203 chr2:24443330 A/G cg06627628 chr2:24431161 ITSN2 0.67 8.13 0.45 1.67e-14 Asthma; CESC cis rs7647973 0.626 rs1586827 chr3:49671224 T/C cg13072238 chr3:49761600 GMPPB -0.45 -5.49 -0.32 9.57e-8 Menarche (age at onset); CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg14393609 chr7:65229607 NA 0.44 6.06 0.35 4.67e-9 Calcium levels; CESC cis rs11077998 0.844 rs12185254 chr17:80498972 C/T cg10255544 chr17:80519551 FOXK2 0.55 8.85 0.48 1.27e-16 Reticulocyte fraction of red cells; CESC cis rs36051895 0.632 rs62541945 chr9:5161571 T/C cg02405213 chr9:5042618 JAK2 -0.49 -5.55 -0.32 6.82e-8 Pediatric autoimmune diseases; CESC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg17724175 chr1:150552817 MCL1 0.4 5.98 0.35 7.05e-9 Melanoma; CESC cis rs936229 1.000 rs936229 chr15:75132319 A/G cg14664628 chr15:75095509 CSK -0.84 -11.11 -0.56 8.71e-24 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs4319547 0.915 rs7966094 chr12:123115771 A/G cg05707623 chr12:122985044 ZCCHC8 -0.59 -6.91 -0.39 3.56e-11 Body mass index; CESC cis rs34734847 0.787 rs1814851 chr12:121128633 C/G cg26008908 chr12:120799332 MSI1 0.35 5.31 0.31 2.33e-7 Mean corpuscular volume; CESC cis rs13242816 1.000 rs2191498 chr7:116138569 C/T cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC cis rs7819412 0.668 rs2409721 chr8:11038244 A/T cg21775007 chr8:11205619 TDH -0.36 -5.07 -0.3 7.4e-7 Triglycerides; CESC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg23796481 chr11:64053134 BAD;GPR137 -0.44 -5.33 -0.31 2.08e-7 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs947211 0.948 rs1775143 chr1:205755550 C/T cg17178900 chr1:205818956 PM20D1 0.4 5.31 0.31 2.36e-7 Parkinson's disease; CESC cis rs6088590 1.000 rs2295354 chr20:33356541 T/C cg06115741 chr20:33292138 TP53INP2 0.6 7.28 0.41 3.73e-12 Coronary artery disease; CESC cis rs9443189 0.813 rs2133191 chr6:76440761 C/T cg01950844 chr6:76311363 SENP6 -0.65 -7.14 -0.4 8.95e-12 Prostate cancer; CESC cis rs1348850 0.651 rs4893931 chr2:178228212 T/C cg23306229 chr2:178417860 TTC30B 0.5 6.67 0.38 1.46e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs853679 0.607 rs17763089 chr6:27835218 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.93 6.78 0.38 7.9e-11 Depression; CESC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg04756594 chr16:24857601 SLC5A11 0.49 5.7 0.33 3.11e-8 Intelligence (multi-trait analysis); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg27415969 chr3:186500848 EIF4A2 -0.47 -6.05 -0.35 5.02e-9 Height; CESC cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg10556349 chr10:835070 NA 0.54 5.39 0.31 1.56e-7 Eosinophil percentage of granulocytes; CESC cis rs3096299 0.967 rs2965937 chr16:89488779 A/T cg08392591 chr16:89556376 ANKRD11 0.44 5.69 0.33 3.28e-8 Multiple myeloma (IgH translocation); CESC cis rs360798 0.512 rs34104251 chr2:62995183 A/G cg17519650 chr2:63277830 OTX1 -0.57 -7.51 -0.42 8.98e-13 Coronary artery disease; CESC cis rs6499129 1.000 rs7185709 chr16:67529349 T/G cg26727032 chr16:67993705 SLC12A4 -0.55 -5.79 -0.34 1.99e-8 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2228479 0.850 rs11076624 chr16:89855749 T/C cg04013166 chr16:89971882 TCF25 0.78 6.67 0.38 1.44e-10 Skin colour saturation; CESC trans rs116095464 0.614 rs56299325 chr5:220594 C/T cg00938859 chr5:1591904 SDHAP3 0.6 6.66 0.38 1.55e-10 Breast cancer; CESC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg00802000 chr16:706648 WDR90 -0.46 -7.12 -0.4 1.02e-11 Height; CESC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.23 0.53 6.6e-21 Prudent dietary pattern; CESC cis rs7818688 0.697 rs112411609 chr8:95980854 C/A cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs9388451 0.839 rs3757217 chr6:126069636 G/C cg05901451 chr6:126070800 HEY2 -0.65 -9.17 -0.49 1.34e-17 Brugada syndrome; CESC cis rs722599 0.748 rs7145173 chr14:75351647 G/A cg11812906 chr14:75593930 NEK9 -0.47 -5.68 -0.33 3.49e-8 IgG glycosylation; CESC cis rs9420 0.961 rs527528 chr11:57433327 C/T cg23127183 chr11:57508653 C11orf31 -0.47 -5.54 -0.32 7.28e-8 Schizophrenia; CESC cis rs9309473 1.000 rs1403284 chr2:73726662 A/G cg20560298 chr2:73613845 ALMS1 0.52 6.43 0.37 5.85e-10 Metabolite levels; CESC cis rs35995292 0.500 rs1019065 chr7:38939775 C/T cg19327137 chr7:38886074 VPS41 0.65 10.88 0.56 4.95e-23 Subjective well-being (multi-trait analysis); CESC cis rs7264396 0.635 rs6058346 chr20:34481043 G/T cg23207816 chr20:34252616 CPNE1;RBM12 0.6 6.96 0.39 2.6e-11 Total cholesterol levels; CESC cis rs68170813 0.559 rs7798223 chr7:106829223 T/C cg02696742 chr7:106810147 HBP1 -0.53 -5.06 -0.3 7.95e-7 Coronary artery disease; CESC cis rs17401966 0.931 rs3748577 chr1:10357406 C/T cg15208524 chr1:10270712 KIF1B -0.43 -5.55 -0.32 6.92e-8 Hepatocellular carcinoma; CESC trans rs3780486 0.881 rs10738906 chr9:33135634 T/C cg20290983 chr6:43655470 MRPS18A 0.98 18.17 0.74 1.8e-48 IgG glycosylation; CESC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.25 0.53 5.71e-21 Prudent dietary pattern; CESC cis rs9951602 0.920 rs28639710 chr18:76679847 G/A cg00806245 chr18:76673096 NA -0.55 -5.94 -0.34 9.03e-9 Obesity-related traits; CESC cis rs9549367 0.826 rs2287249 chr13:113889355 A/G cg00898013 chr13:113819073 PROZ -0.5 -6.86 -0.39 4.95e-11 Platelet distribution width; CESC trans rs2018683 0.707 rs4722877 chr7:28972906 A/G cg19402173 chr7:128379420 CALU -0.51 -6.73 -0.38 1.06e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs965469 1.000 rs6139088 chr20:3329063 G/A cg25506879 chr20:3388711 C20orf194 -0.54 -5.78 -0.33 2.14e-8 IFN-related cytopenia; CESC cis rs7631605 0.905 rs11720073 chr3:37018991 C/T cg22985146 chr3:37219077 LRRFIP2 -0.33 -5.09 -0.3 6.91e-7 Cerebrospinal P-tau181p levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23283474 chr11:46450417 AMBRA1 -0.4 -6.4 -0.37 7.03e-10 Gut microbiota (bacterial taxa); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09254969 chr5:141303622 KIAA0141 0.57 6.3 0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs9611565 0.921 rs6002333 chr22:41719469 C/T cg17376030 chr22:41985996 PMM1 0.58 6.17 0.35 2.58e-9 Vitiligo; CESC cis rs9768139 1.000 rs9768139 chr7:158120731 G/A cg25566285 chr7:158114605 PTPRN2 -0.51 -8.75 -0.47 2.61e-16 Calcium levels; CESC cis rs7122539 0.734 rs2513658 chr11:66628249 G/A cg24851651 chr11:66362959 CCS -0.48 -6.92 -0.39 3.32e-11 HIV-1 susceptibility; CESC cis rs7296418 0.961 rs1790122 chr12:123606739 G/A cg00376283 chr12:123451042 ABCB9 0.72 10.11 0.53 1.55e-20 Platelet count; CESC cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg21573476 chr21:45109991 RRP1B -0.46 -6.25 -0.36 1.63e-9 Mean corpuscular volume; CESC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg18337363 chr3:52569053 NT5DC2 0.3 5.46 0.32 1.07e-7 Electroencephalogram traits; CESC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.45 6.86 0.39 4.75e-11 Total body bone mineral density; CESC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7818688 0.697 rs76215523 chr8:95987015 T/C cg16049864 chr8:95962084 TP53INP1 0.55 5.6 0.33 5.32e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs863345 0.604 rs4584390 chr1:158505975 T/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.82 -0.39 6.1e-11 Pneumococcal bacteremia; CESC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg06873352 chr17:61820015 STRADA 0.72 12.39 0.61 4.13e-28 Prudent dietary pattern; CESC cis rs6541297 1.000 rs7543050 chr1:230278291 C/G cg20703242 chr1:230279135 GALNT2 0.68 10.7 0.55 1.96e-22 Coronary artery disease; CESC cis rs1865760 0.566 rs9366634 chr6:26072396 C/G cg16482183 chr6:26056742 HIST1H1C 0.39 5.33 0.31 2.12e-7 Height; CESC cis rs514406 0.893 rs1242317 chr1:53414766 T/C cg08859206 chr1:53392774 SCP2 -0.57 -7.35 -0.41 2.42e-12 Monocyte count; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg03560053 chr19:9946083 PIN1 -0.46 -6.09 -0.35 4e-9 Recombination measurement; CESC cis rs2243480 0.901 rs35087093 chr7:65405208 C/T cg18252515 chr7:66147081 NA -1.06 -9.79 -0.52 1.67e-19 Diabetic kidney disease; CESC cis rs4474465 0.850 rs10751294 chr11:78253303 T/A cg27205649 chr11:78285834 NARS2 0.43 5.34 0.31 2.05e-7 Alzheimer's disease (survival time); CESC cis rs909002 0.849 rs10914456 chr1:32088171 T/C cg13919466 chr1:32135498 COL16A1 -0.47 -8.26 -0.45 7.22e-15 Intelligence (multi-trait analysis); CESC cis rs6032067 0.852 rs17333103 chr20:43803613 C/T cg11264863 chr20:43835661 SEMG1 0.5 5.41 0.32 1.41e-7 Blood protein levels; CESC cis rs28489187 0.617 rs11161606 chr1:85853902 T/C cg16011679 chr1:85725395 C1orf52 0.43 5.08 0.3 7.05e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs2404602 0.563 rs12914005 chr15:76765667 A/G cg22467129 chr15:76604101 ETFA -0.38 -5.86 -0.34 1.38e-8 Blood metabolite levels; CESC cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg16339924 chr4:17578868 LAP3 0.65 8.07 0.44 2.45e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12504415 chr17:74722752 JMJD6;C17orf95 0.58 6.69 0.38 1.32e-10 Gut microbiome composition (summer); CESC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg22508957 chr16:3507546 NAT15 -0.49 -7.86 -0.43 9.92e-14 Tuberculosis; CESC cis rs7089973 0.604 rs1924034 chr10:116578539 C/T cg25233709 chr10:116636983 FAM160B1 0.36 5.89 0.34 1.2e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2228479 0.557 rs11641726 chr16:89891619 G/A cg00800038 chr16:89945340 TCF25 -0.89 -6.88 -0.39 4.34e-11 Skin colour saturation; CESC cis rs35146811 0.844 rs12705070 chr7:99656927 A/G cg22906224 chr7:99728672 NA 0.49 5.95 0.34 8.58e-9 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25595571 chr14:104029029 BAG5;C14orf153 0.59 7.18 0.4 7.12e-12 Gut microbiome composition (summer); CESC cis rs6448317 0.954 rs12186333 chr4:24919774 T/C cg21108841 chr4:24914750 CCDC149 -0.56 -6.63 -0.38 1.85e-10 Heschl's gyrus morphology; CESC cis rs6060717 0.536 rs8125966 chr20:34511823 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.61 0.33 4.97e-8 Hip circumference adjusted for BMI; CESC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg25072359 chr17:41440525 NA 0.48 6.27 0.36 1.43e-9 Menopause (age at onset); CESC cis rs7191439 0.522 rs8060640 chr16:88744430 G/C cg27087555 chr16:88793112 FAM38A -1.11 -6.75 -0.38 9.45e-11 Plateletcrit; CESC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg17179660 chr6:151773299 C6orf211;RMND1 -0.42 -5.28 -0.31 2.67e-7 Menarche (age at onset); CESC trans rs7246657 0.943 rs7255996 chr19:37971699 G/A cg24637308 chr11:6592297 DNHD1 0.54 6.24 0.36 1.75e-9 Coronary artery calcification; CESC cis rs3824344 0.507 rs10814501 chr9:37019304 C/T cg14294708 chr9:37120828 ZCCHC7 0.39 5.17 0.3 4.61e-7 Intelligence; CESC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg24562669 chr7:97807699 LMTK2 0.48 7.1 0.4 1.13e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.91 9.13 0.49 1.81e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6142102 0.602 rs4911395 chr20:32579901 T/G cg08999081 chr20:33150536 PIGU 0.33 5.03 0.3 9.07e-7 Skin pigmentation; CESC cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg06697600 chr4:7070879 GRPEL1 -0.49 -7.34 -0.41 2.55e-12 Monocyte percentage of white cells; CESC cis rs34233420 1 rs34233420 chr17:38004929 GATTT/G cg20243544 chr17:37824526 PNMT 0.53 7.17 0.4 7.65e-12 Lymphocyte counts; CESC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg15147215 chr3:52552868 STAB1 -0.31 -5.26 -0.31 2.96e-7 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00106744 chr21:27106928 ATP5J;GABPA 0.64 6.93 0.39 3.15e-11 Gut microbiome composition (summer); CESC cis rs9796 0.870 rs12905926 chr15:41283408 G/A cg18705301 chr15:41695430 NDUFAF1 0.44 6.5 0.37 4.03e-10 Menopause (age at onset); CESC cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg04455712 chr21:45112962 RRP1B 0.48 7.35 0.41 2.5e-12 Mean corpuscular volume; CESC cis rs57506017 0.585 rs13230513 chr7:12268243 C/A cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.64e-7 Neuroticism; CESC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg09177884 chr7:1199841 ZFAND2A 0.54 7.12 0.4 1e-11 Longevity;Endometriosis; CESC cis rs6667605 0.527 rs6673993 chr1:2552071 T/C cg18854424 chr1:2615690 NA 0.31 6.32 0.36 1.09e-9 Inflammatory bowel disease;Ulcerative colitis; CESC cis rs67311347 1.000 rs34762643 chr3:40475433 C/T cg24209194 chr3:40518798 ZNF619 0.46 5.99 0.35 6.9e-9 Renal cell carcinoma; CESC cis rs965469 0.744 rs6139093 chr20:3334838 A/G cg17110299 chr20:3385021 C20orf194 0.4 5.24 0.31 3.22e-7 IFN-related cytopenia; CESC cis rs7914558 0.966 rs10748835 chr10:104660256 C/T cg04362960 chr10:104952993 NT5C2 0.42 5.37 0.31 1.72e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7223966 1.000 rs11658175 chr17:61923838 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.26 0.36 1.51e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg03352830 chr11:487213 PTDSS2 0.72 6.69 0.38 1.33e-10 Body mass index; CESC cis rs2191566 1.000 rs369106 chr19:44506930 C/T cg20607764 chr19:44506953 ZNF230 0.62 8.22 0.45 9.24e-15 Acute lymphoblastic leukemia (childhood); CESC cis rs7044106 0.690 rs10739569 chr9:123361027 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.55 7.29 0.41 3.5e-12 Hip circumference adjusted for BMI; CESC cis rs1881797 1.000 rs12081895 chr1:247686666 C/G cg05639522 chr1:247681581 NA 0.46 6.02 0.35 5.84e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs8031584 0.918 rs35396566 chr15:31263057 T/C cg14829155 chr15:31115871 NA -0.76 -9.75 -0.51 2.17e-19 Huntington's disease progression; CESC cis rs1642645 0.793 rs4660211 chr1:42484294 T/C cg16685388 chr1:42384056 HIVEP3 0.38 5.68 0.33 3.57e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.81 0.43 1.38e-13 Electroencephalogram traits; CESC cis rs9914988 0.943 rs9891925 chr17:27104540 A/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs1983891 0.706 rs913077 chr6:41569157 G/A cg20194872 chr6:41519635 FOXP4 0.43 5.95 0.34 8.39e-9 Prostate cancer; CESC trans rs875971 0.642 rs35526611 chr7:66094008 C/T cg26939375 chr7:64535504 NA -0.62 -8.25 -0.45 7.44e-15 Aortic root size; CESC cis rs1348850 0.914 rs3902850 chr2:178315899 G/A cg23306229 chr2:178417860 TTC30B 0.65 8.25 0.45 7.69e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8180040 0.966 rs12486969 chr3:47429003 G/C cg27129171 chr3:47204927 SETD2 -0.64 -9.82 -0.52 1.29e-19 Colorectal cancer; CESC cis rs2243480 1.000 rs160648 chr7:65543384 C/A cg13147721 chr7:65941812 NA -0.93 -8.86 -0.48 1.16e-16 Diabetic kidney disease; CESC cis rs11997175 0.704 rs11775534 chr8:33695232 G/A ch.8.33884649F chr8:33765107 NA 0.44 5.6 0.33 5.26e-8 Body mass index; CESC cis rs2760061 0.819 rs708114 chr1:228197496 G/A cg18477163 chr1:228402036 OBSCN 0.32 5.62 0.33 4.75e-8 Diastolic blood pressure; CESC cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg19077165 chr18:44547161 KATNAL2 0.52 7.26 0.41 4.23e-12 Personality dimensions; CESC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.57 6.82 0.39 6.1e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9486719 0.843 rs1009597 chr6:96843540 A/T cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07209141 chr11:68171070 LRP5 -0.56 -6.72 -0.38 1.1e-10 Gut microbiome composition (summer); CESC cis rs2710642 0.564 rs6545963 chr2:62822891 C/T cg17519650 chr2:63277830 OTX1 -0.5 -6.59 -0.38 2.41e-10 LDL cholesterol levels;LDL cholesterol; CESC trans rs11098499 0.820 rs13128602 chr4:120459366 C/T cg25214090 chr10:38739885 LOC399744 -0.69 -9.8 -0.52 1.51e-19 Corneal astigmatism; CESC trans rs163030 0.902 rs406068 chr5:76740605 G/A cg26150533 chr8:82396069 FABP4 -0.39 -6.09 -0.35 4.02e-9 Caudate nucleus volume; CESC trans rs8073060 0.586 rs225288 chr17:33929291 G/A cg19694781 chr19:47549865 TMEM160 -0.73 -7.01 -0.4 1.96e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs9658691 0.607 rs12415680 chr10:90780737 A/T cg03111039 chr10:90751583 FAS;ACTA2 -0.58 -5.25 -0.31 3.08e-7 Mosquito bite size; CESC cis rs116979167 0.575 rs1728649 chr7:105170570 A/G cg19920283 chr7:105172520 RINT1 0.54 6.29 0.36 1.3e-9 Bipolar disorder (body mass index interaction); CESC cis rs7481584 0.624 rs397919 chr11:3063094 A/C cg25174290 chr11:3078921 CARS -0.52 -7.2 -0.4 6.11e-12 Calcium levels; CESC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg24818145 chr4:99064322 C4orf37 0.4 5.24 0.31 3.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7553864 0.667 rs1886633 chr1:87610356 G/A cg17420885 chr1:87600446 LOC339524 -0.44 -6.0 -0.35 6.35e-9 Smoking behavior; CESC cis rs2439831 0.867 rs8041132 chr15:43635136 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.83 12.31 0.6 7.84e-28 Lung cancer in ever smokers; CESC cis rs9902453 1.000 rs4074170 chr17:28381141 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.09e-13 Coffee consumption (cups per day); CESC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg24578937 chr1:2090814 PRKCZ -0.36 -6.28 -0.36 1.37e-9 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13179880 chr1:46016123 AKR1A1 0.4 6.1 0.35 3.8e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1559088 0.948 rs9304844 chr19:33579935 G/T cg27124370 chr19:33622961 WDR88 0.48 6.33 0.36 1.06e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2795502 0.873 rs3121327 chr10:43388285 G/A cg20628663 chr10:43360327 NA 0.54 6.07 0.35 4.48e-9 Blood protein levels; CESC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.59 -0.32 5.57e-8 Aortic root size; CESC cis rs910316 0.967 rs12890371 chr14:75593839 T/C cg16144293 chr14:75469539 EIF2B2 -0.39 -5.12 -0.3 5.79e-7 Height; CESC cis rs7512552 0.839 rs4581308 chr1:150276872 A/G cg15654264 chr1:150340011 RPRD2 -0.41 -5.27 -0.31 2.77e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs6582630 0.538 rs12305104 chr12:38336353 C/T cg26384229 chr12:38710491 ALG10B -0.41 -5.33 -0.31 2.09e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.53 8.02 0.44 3.41e-14 Bipolar disorder; CESC cis rs116095464 0.558 rs3213838 chr5:223890 G/C cg22857025 chr5:266934 NA -1.27 -18.88 -0.76 5.63e-51 Breast cancer; CESC cis rs8020095 0.571 rs8022328 chr14:67253035 A/G cg19548862 chr14:67692701 FAM71D 0.47 5.77 0.33 2.26e-8 Depression (quantitative trait); CESC cis rs12477438 0.501 rs34272114 chr2:99737443 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 12.89 0.62 7.58e-30 Chronic sinus infection; CESC cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4604732 0.527 rs77361748 chr1:247626475 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg10295955 chr4:187884368 NA 0.93 15.13 0.68 1.07e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs34779708 0.966 rs4934736 chr10:35496868 G/A cg04310649 chr10:35416472 CREM -0.52 -6.31 -0.36 1.18e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7647973 0.626 rs1996663 chr3:49878264 C/G cg13072238 chr3:49761600 GMPPB 0.47 5.88 0.34 1.23e-8 Menarche (age at onset); CESC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg20151795 chr6:28129481 ZNF389 0.4 5.09 0.3 6.94e-7 Parkinson's disease; CESC cis rs2243480 0.901 rs34807232 chr7:65965133 G/A cg12463550 chr7:65579703 CRCP 0.71 5.5 0.32 8.86e-8 Diabetic kidney disease; CESC cis rs61841072 0.961 rs6697552 chr1:243126352 C/T cg02356786 chr1:243265016 LOC731275 0.4 5.07 0.3 7.42e-7 Schizophrenia; CESC cis rs854765 0.618 rs8068820 chr17:17834119 A/G cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.9e-9 Total body bone mineral density; CESC cis rs1878931 0.520 rs12447807 chr16:3413896 A/G cg00484396 chr16:3507460 NAT15 -0.38 -5.8 -0.34 1.85e-8 Body mass index (adult); CESC cis rs7824557 0.527 rs2572448 chr8:11239352 G/A cg21775007 chr8:11205619 TDH -0.51 -7.7 -0.43 2.64e-13 Retinal vascular caliber; CESC cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.9 0.34 1.09e-8 Colonoscopy-negative controls vs population controls; CESC cis rs710216 0.917 rs710223 chr1:43411038 C/G cg07803811 chr1:43423981 SLC2A1 0.5 5.21 0.3 3.84e-7 Red cell distribution width; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07663789 chr5:32711429 NPR3 -0.53 -6.66 -0.38 1.56e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs16937 0.711 rs10751431 chr1:205128059 C/T cg00857998 chr1:205179979 DSTYK 0.4 5.29 0.31 2.59e-7 Schizophrenia; CESC cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg00033643 chr7:134001901 SLC35B4 0.44 5.66 0.33 4.01e-8 Mean platelet volume; CESC cis rs4654899 0.931 rs4654730 chr1:21229286 A/T cg05370193 chr1:21551575 ECE1 0.37 5.52 0.32 8.22e-8 Superior frontal gyrus grey matter volume; CESC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg06138931 chr13:21896616 NA 0.52 5.46 0.32 1.1e-7 White matter hyperintensity burden; CESC cis rs3820068 0.603 rs6429768 chr1:15963531 G/A cg16988262 chr1:15930761 NA 0.34 5.45 0.32 1.16e-7 Systolic blood pressure; CESC cis rs8060686 0.516 rs2290699 chr16:68289059 C/T cg26727032 chr16:67993705 SLC12A4 -0.57 -7.36 -0.41 2.28e-12 HDL cholesterol;Metabolic syndrome; CESC cis rs9287719 0.967 rs728134 chr2:10745187 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.78 -0.33 2.05e-8 Prostate cancer; CESC cis rs116979167 0.575 rs1728649 chr7:105170570 A/G cg13798780 chr7:105162888 PUS7 0.52 6.3 0.36 1.22e-9 Bipolar disorder (body mass index interaction); CESC cis rs3540 0.512 rs8033595 chr15:91083353 G/A cg10434728 chr15:90938212 IQGAP1 -0.4 -7.16 -0.4 7.74e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19099234 chr5:137911120 HSPA9 0.58 6.65 0.38 1.65e-10 Gut microbiome composition (summer); CESC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg08027265 chr7:2291960 NA -0.35 -5.11 -0.3 6.23e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4975616 0.869 rs380286 chr5:1320247 G/A cg26373071 chr5:1325741 CLPTM1L 0.43 6.94 0.39 3.1e-11 Lung cancer; CESC cis rs1348850 0.918 rs12622298 chr2:178450651 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 8.01 0.44 3.76e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg16262614 chr3:133464971 TF 0.3 5.46 0.32 1.11e-7 Iron status biomarkers; CESC cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg24308560 chr3:49941425 MST1R -0.63 -9.04 -0.49 3.45e-17 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00304072 chr15:49338551 SECISBP2L 0.59 6.87 0.39 4.54e-11 Gut microbiome composition (summer); CESC cis rs832540 0.931 rs832536 chr5:56212595 C/T cg14703610 chr5:56206110 C5orf35 0.55 7.24 0.41 4.82e-12 Coronary artery disease; CESC cis rs8017423 0.935 rs9944124 chr14:90791501 T/C cg14092571 chr14:90743983 NA -0.54 -8.24 -0.45 8.15e-15 Mortality in heart failure; CESC cis rs4253772 0.513 rs6008700 chr22:46722560 C/T cg00784671 chr22:46762841 CELSR1 -0.4 -5.31 -0.31 2.27e-7 LDL cholesterol;Cholesterol, total; CESC trans rs765547 1.000 rs4922117 chr8:19852586 A/G cg12649343 chr22:47023005 GRAMD4 -0.3 -6.14 -0.35 3.04e-9 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs7772486 0.875 rs7766463 chr6:146364453 A/G cg05347473 chr6:146136440 FBXO30 0.47 6.2 0.36 2.21e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs9487051 0.676 rs4406271 chr6:109598213 G/A cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.7 0.33 3.26e-8 Bipolar disorder; CESC cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg04450456 chr4:17643702 FAM184B 0.36 5.15 0.3 5.01e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs67478160 0.643 rs12880167 chr14:104300829 C/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.37 0.54 2.23e-21 Schizophrenia; CESC cis rs3096299 0.933 rs2965939 chr16:89493043 G/A cg02034447 chr16:89574710 SPG7 0.42 5.23 0.31 3.45e-7 Multiple myeloma (IgH translocation); CESC cis rs7202877 0.706 rs1074961 chr16:75389484 C/T cg04384234 chr16:75411784 CFDP1 -0.47 -5.73 -0.33 2.72e-8 Type 2 diabetes;Type 1 diabetes; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg06419568 chr12:46776835 NA -0.46 -6.24 -0.36 1.76e-9 Height; CESC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs425277 1.000 rs385039 chr1:2077409 C/T cg16545954 chr1:2118288 C1orf86 -0.33 -5.57 -0.32 6.3e-8 Height; CESC cis rs3812762 0.871 rs3844100 chr11:8817808 A/G cg03980550 chr11:8754370 ST5 0.36 5.16 0.3 4.92e-7 Hypospadias; CESC cis rs796364 0.806 rs79725795 chr2:201083534 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.75 -6.74 -0.38 9.79e-11 Schizophrenia; CESC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg11890956 chr21:40555474 PSMG1 0.96 15.98 0.7 9.91e-41 Cognitive function; CESC cis rs7786877 0.723 rs11764045 chr7:100212754 C/T cg20848291 chr7:100343083 ZAN -0.59 -6.0 -0.35 6.36e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9467711 0.559 rs13208916 chr6:26601940 G/A cg21479132 chr6:26055353 NA 0.58 5.18 0.3 4.44e-7 Autism spectrum disorder or schizophrenia; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18085206 chr17:1359243 CRK -0.48 -6.16 -0.35 2.66e-9 Asthma; CESC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg07701084 chr6:150067640 NUP43 0.44 5.94 0.34 9.04e-9 Lung cancer; CESC cis rs9560113 0.509 rs4771759 chr13:112209217 A/G cg10483660 chr13:112241077 NA -0.44 -7.66 -0.43 3.53e-13 Menarche (age at onset); CESC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg13206674 chr6:150067644 NUP43 0.41 5.76 0.33 2.3e-8 Lung cancer; CESC cis rs6674176 0.660 rs12726706 chr1:44399942 G/A cg13606994 chr1:44402422 ARTN -0.4 -6.23 -0.36 1.84e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg12463550 chr7:65579703 CRCP 0.69 5.37 0.31 1.75e-7 Diabetic kidney disease; CESC cis rs4975709 0.569 rs2353583 chr5:1858834 G/C cg11168104 chr5:1857477 NA -0.39 -5.54 -0.32 7.22e-8 Cardiovascular disease risk factors; CESC cis rs8067545 0.967 rs4924801 chr17:19921070 T/C cg13482628 chr17:19912719 NA 0.46 6.2 0.36 2.19e-9 Schizophrenia; CESC cis rs9302635 0.513 rs7198572 chr16:72183220 G/A cg16558253 chr16:72132732 DHX38 -0.42 -5.15 -0.3 5.18e-7 Blood protein levels; CESC trans rs1351696 1 rs1351696 chr11:48382471 A/G cg15704280 chr7:45808275 SEPT13 -0.68 -6.25 -0.36 1.61e-9 D-dimer levels; CESC cis rs55986470 0.763 rs6713788 chr2:239456932 T/A cg18131467 chr2:239335373 ASB1 -0.56 -6.27 -0.36 1.47e-9 Chronotype; CESC cis rs9911578 1.000 rs9902994 chr17:56948722 T/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.16 0.3 4.87e-7 Intelligence (multi-trait analysis); CESC cis rs7927771 0.524 rs11039415 chr11:47845814 A/G cg18512352 chr11:47633146 NA 0.35 5.33 0.31 2.05e-7 Subjective well-being; CESC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg03934478 chr11:495069 RNH1 0.55 5.36 0.31 1.86e-7 Body mass index; CESC cis rs425277 1.000 rs425277 chr1:2069172 C/T cg23803603 chr1:2058230 PRKCZ 0.33 5.06 0.3 7.86e-7 Height; CESC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg23281280 chr6:28129359 ZNF389 0.53 7.62 0.42 4.57e-13 Parkinson's disease; CESC cis rs4722166 0.630 rs6969258 chr7:22782528 C/T cg05265849 chr7:22767390 IL6 0.57 7.11 0.4 1.06e-11 Lung cancer; CESC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg07507251 chr3:52567010 NT5DC2 0.39 7.32 0.41 2.94e-12 Bipolar disorder; CESC cis rs3026101 0.671 rs1806222 chr17:5289676 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.8 0.34 1.9e-8 Body mass index; CESC cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg18876405 chr7:65276391 NA -0.59 -7.84 -0.43 1.11e-13 Aortic root size; CESC cis rs113835537 0.935 rs117480267 chr11:66398596 C/T cg22134325 chr11:66188745 NPAS4 0.51 5.89 0.34 1.17e-8 Airway imaging phenotypes; CESC cis rs8141529 0.748 rs9620841 chr22:29290981 C/T cg15103426 chr22:29168792 CCDC117 0.61 7.95 0.44 5.34e-14 Lymphocyte counts; CESC trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg03929089 chr4:120376271 NA -0.76 -8.02 -0.44 3.35e-14 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03149719 chr17:1358724 CRK 0.46 6.05 0.35 5.04e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg17724175 chr1:150552817 MCL1 0.44 7.23 0.41 5.25e-12 Tonsillectomy; CESC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg13393036 chr8:95962371 TP53INP1 -0.49 -10.52 -0.54 7.38e-22 Type 2 diabetes; CESC cis rs63406760 1 rs63406760 chr12:123742692 TG/T cg19016782 chr12:123741754 C12orf65 -0.48 -6.9 -0.39 3.71e-11 Allergic disease (asthma, hay fever or eczema); CESC trans rs2727020 0.590 rs7949936 chr11:49378902 G/A cg03929089 chr4:120376271 NA -0.65 -7.11 -0.4 1.07e-11 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15133824 chr2:97523823 ANKRD39 0.53 6.61 0.38 2.11e-10 Gut microbiome composition (summer); CESC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.97 -0.34 7.45e-9 Total body bone mineral density; CESC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg26314531 chr2:26401878 FAM59B 0.65 7.61 0.42 4.86e-13 Gut microbiome composition (summer); CESC trans rs9467711 0.538 rs35934643 chr6:26355094 G/A cg06606381 chr12:133084897 FBRSL1 -0.77 -7.0 -0.4 2.04e-11 Autism spectrum disorder or schizophrenia; CESC cis rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04519918 chr16:57278807 ARL2BP -0.39 -5.81 -0.34 1.75e-8 Gambling; CESC cis rs6430585 0.528 rs309166 chr2:136667487 C/T cg07169764 chr2:136633963 MCM6 1.03 14.65 0.67 5.12e-36 Corneal structure; CESC cis rs7927771 0.864 rs10838724 chr11:47527052 G/T cg20307385 chr11:47447363 PSMC3 -0.47 -5.66 -0.33 3.94e-8 Subjective well-being; CESC cis rs12136530 0.593 rs881248 chr1:19733961 C/T cg01832549 chr1:19774989 CAPZB 0.44 6.15 0.35 2.77e-9 Lead levels in blood; CESC cis rs7247513 0.930 rs28368916 chr19:12701577 T/G cg01871581 chr19:12707946 ZNF490 -0.89 -15.13 -0.68 1.1e-37 Bipolar disorder; CESC cis rs7249142 0.597 rs759999 chr19:19281207 A/C cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.28 5.16 0.3 4.77e-7 IgG glycosylation; CESC cis rs10870270 0.830 rs11146269 chr10:133761820 G/A cg26149184 chr10:133730230 NA 0.37 5.07 0.3 7.58e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs12142240 0.738 rs41293277 chr1:46806550 C/T cg00530320 chr1:46809349 NSUN4 0.59 7.85 0.43 1.02e-13 Menopause (age at onset); CESC cis rs3136441 0.892 rs11039024 chr11:46923168 C/T cg25783544 chr11:47291846 MADD 0.52 5.27 0.31 2.88e-7 HDL cholesterol; CESC trans rs4843747 0.671 rs28451517 chr16:88109127 A/C cg26811252 chr16:29126840 RRN3P2 0.69 9.55 0.51 9.45e-19 Menopause (age at onset); CESC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg23708337 chr7:1209742 NA 0.54 5.38 0.31 1.61e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1538970 0.851 rs61788285 chr1:45919234 A/C cg05343316 chr1:45956843 TESK2 0.91 12.32 0.6 7.03e-28 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07639963 chr12:77157760 ZDHHC17 0.5 6.04 0.35 5.08e-9 Gut microbiome composition (summer); CESC cis rs62064224 0.748 rs72813015 chr17:30693331 T/C cg18200150 chr17:30822561 MYO1D 0.68 10.43 0.54 1.45e-21 Schizophrenia; CESC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg01341218 chr17:43662625 NA 0.92 10.72 0.55 1.65e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6665290 0.904 rs3795451 chr1:227181923 C/T cg10327440 chr1:227177885 CDC42BPA -1.21 -33.56 -0.9 2.09e-97 Myeloid white cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14505161 chr7:30544458 GGCT 0.57 6.16 0.35 2.71e-9 Gut microbiome composition (summer); CESC cis rs8017423 1.000 rs11622075 chr14:90669894 G/T cg14092571 chr14:90743983 NA -0.56 -8.31 -0.45 4.98e-15 Mortality in heart failure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17444015 chr1:2322981 MORN1;RER1 -0.45 -6.15 -0.35 2.78e-9 Fibrinogen levels; CESC cis rs9303280 0.719 rs56750287 chr17:38062944 A/C cg20243544 chr17:37824526 PNMT 0.52 6.76 0.38 8.67e-11 Self-reported allergy; CESC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 5.07 0.3 7.31e-7 Calcium levels; CESC cis rs9790314 0.747 rs6789244 chr3:160866230 A/C cg03342759 chr3:160939853 NMD3 -0.42 -6.02 -0.35 5.77e-9 Morning vs. evening chronotype; CESC cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg20476274 chr7:133979776 SLC35B4 0.68 10.16 0.53 1.04e-20 Mean platelet volume; CESC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg17949981 chr6:28129498 ZNF389 0.45 5.49 0.32 9.35e-8 Depression; CESC cis rs1843834 0.539 rs2047135 chr2:225427302 G/C cg22455342 chr2:225449267 CUL3 0.71 9.77 0.51 1.92e-19 IgE levels in asthmatics (D.p. specific); CESC cis rs7208859 0.673 rs1347359 chr17:28914529 T/C cg17105886 chr17:28927953 LRRC37B2 0.58 5.06 0.3 7.98e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1005277 0.579 rs1780145 chr10:38537070 A/G cg25517755 chr10:38738941 LOC399744 -0.49 -6.39 -0.37 7.49e-10 Extrinsic epigenetic age acceleration; CESC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 10.75 0.55 1.31e-22 Platelet count; CESC trans rs6794880 0.778 rs113110726 chr3:84420854 G/A cg03554283 chr8:76319451 NA 0.57 6.07 0.35 4.44e-9 Body mass index (joint analysis main effects and smoking interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs3749237 0.595 rs1568661 chr3:49520958 A/G cg07636037 chr3:49044803 WDR6 0.65 9.47 0.5 1.67e-18 Resting heart rate; CESC cis rs796364 0.951 rs7586320 chr2:201068209 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.61 5.74 0.33 2.56e-8 Schizophrenia; CESC cis rs9488822 0.676 rs1338667 chr6:116323910 T/A cg26893134 chr6:116381904 FRK 0.25 6.04 0.35 5.06e-9 Cholesterol, total;LDL cholesterol; CESC cis rs870825 0.616 rs7659101 chr4:185632158 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.84 0.39 5.54e-11 Blood protein levels; CESC cis rs537626 0.848 rs624797 chr11:69308575 G/T cg08353955 chr11:69289746 NA 0.48 6.02 0.35 5.86e-9 Breast cancer (early onset); CESC cis rs2191566 0.821 rs59756444 chr19:44513656 C/G cg20607764 chr19:44506953 ZNF230 -0.62 -8.18 -0.45 1.17e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs4746818 0.711 rs2491024 chr10:70847084 T/C cg11621586 chr10:70884670 VPS26A 0.62 7.09 0.4 1.2e-11 Left atrial antero-posterior diameter; CESC cis rs1788820 0.917 rs4800489 chr18:21125942 A/G cg14672496 chr18:21087552 C18orf8 0.55 7.55 0.42 6.97e-13 Body mass index; CESC cis rs244293 0.729 rs2332313 chr17:53018825 T/G cg19360675 chr17:53046073 COX11;STXBP4 -0.44 -5.69 -0.33 3.3e-8 Menarche (age at onset); CESC cis rs34172651 0.606 rs7194189 chr16:24703484 G/T cg04756594 chr16:24857601 SLC5A11 -0.53 -6.87 -0.39 4.58e-11 Intelligence (multi-trait analysis); CESC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg24250549 chr1:154909240 PMVK 0.48 6.13 0.35 3.22e-9 Prostate cancer; CESC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg00129232 chr17:37814104 STARD3 -0.55 -7.26 -0.41 4.23e-12 Glomerular filtration rate (creatinine); CESC cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg06212747 chr3:49208901 KLHDC8B 0.74 10.01 0.52 3.14e-20 Parkinson's disease; CESC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg08704250 chr15:31115839 NA 0.63 8.65 0.47 5.15e-16 Huntington's disease progression; CESC cis rs4953318 0.619 rs12105417 chr2:46361255 A/C cg12428440 chr2:46370979 PRKCE 0.5 6.7 0.38 1.25e-10 Red blood cell count;Hematocrit;Red blood cell traits; CESC cis rs9443189 0.615 rs618239 chr6:76350038 A/G cg01950844 chr6:76311363 SENP6 0.87 9.2 0.49 1.1e-17 Prostate cancer; CESC cis rs9908102 0.740 rs73981608 chr17:12903928 C/T cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs1577917 1.000 rs1018184 chr6:86648475 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.42 5.58 0.32 5.98e-8 Response to antipsychotic treatment; CESC cis rs10887741 0.606 rs3824722 chr10:89435723 C/G cg13926569 chr10:89418898 PAPSS2 0.47 7.15 0.4 8.25e-12 Exercise (leisure time); CESC cis rs644799 0.562 rs1313288 chr11:95520695 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.49 6.47 0.37 4.68e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11630290 0.592 rs11634436 chr15:64158394 T/G cg12036633 chr15:63758958 NA 0.44 5.32 0.31 2.19e-7 Iris characteristics; CESC cis rs13095912 0.752 rs62291883 chr3:185313842 T/C cg11274856 chr3:185301563 NA 0.41 6.36 0.36 8.6e-10 Systolic blood pressure; CESC cis rs6732160 0.691 rs7599223 chr2:73427103 A/G cg01422370 chr2:73384389 NA 0.44 7.38 0.41 1.99e-12 Intelligence (multi-trait analysis); CESC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg00129232 chr17:37814104 STARD3 0.56 7.29 0.41 3.49e-12 Glomerular filtration rate (creatinine); CESC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg02569458 chr12:86230093 RASSF9 0.51 7.53 0.42 7.74e-13 Major depressive disorder; CESC cis rs425277 0.959 rs77665022 chr1:2065958 C/T cg24578937 chr1:2090814 PRKCZ 0.53 9.07 0.49 2.78e-17 Height; CESC trans rs3857536 0.505 rs208459 chr6:66911055 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.57 -6.7 -0.38 1.23e-10 Blood trace element (Cu levels); CESC cis rs8180040 1.000 rs11714294 chr3:47339723 G/A cg27129171 chr3:47204927 SETD2 -0.66 -10.18 -0.53 9.2e-21 Colorectal cancer; CESC trans rs3942852 0.910 rs11603850 chr11:48140900 G/A cg15704280 chr7:45808275 SEPT13 -0.59 -6.53 -0.37 3.33e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs644799 0.648 rs1255178 chr11:95471908 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.43 5.98 0.34 7.37e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.34 -5.58 -0.32 5.97e-8 Cystic fibrosis severity; CESC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg11764359 chr7:65958608 NA 0.7 9.23 0.49 8.79e-18 Aortic root size; CESC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg12365402 chr11:9010492 NRIP3 -0.31 -5.06 -0.3 8.03e-7 Hemoglobin concentration; CESC cis rs2625529 0.591 rs7172158 chr15:72405313 T/C cg16672083 chr15:72433130 SENP8 0.46 6.76 0.38 8.83e-11 Red blood cell count; CESC cis rs3806933 0.522 rs34962120 chr5:110446091 G/A cg04022379 chr5:110408740 TSLP 0.46 7.43 0.42 1.49e-12 Eosinophilic esophagitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24683561 chr1:154934703 PYGO2 0.58 6.18 0.35 2.34e-9 Gut microbiome composition (summer); CESC cis rs2239547 0.562 rs35380116 chr3:52979178 A/G cg11645453 chr3:52864694 ITIH4 -0.32 -5.43 -0.32 1.26e-7 Schizophrenia; CESC cis rs7647973 0.580 rs35218722 chr3:49275805 A/G cg02487422 chr3:49467188 NICN1 0.39 5.43 0.32 1.27e-7 Menarche (age at onset); CESC cis rs8114671 0.562 rs6087643 chr20:33474462 C/T cg07148914 chr20:33460835 GGT7 0.46 6.11 0.35 3.46e-9 Height; CESC cis rs889398 0.771 rs1566454 chr16:69900083 C/T cg09409435 chr16:70099608 PDXDC2 0.4 5.11 0.3 6.15e-7 Body mass index; CESC cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg05347473 chr6:146136440 FBXO30 0.57 7.24 0.41 4.72e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs4253772 0.550 rs9615913 chr22:46668515 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.72 -8.71 -0.47 3.28e-16 LDL cholesterol;Cholesterol, total; CESC cis rs3936840 0.565 rs8006911 chr14:102975265 A/G cg18135206 chr14:102964638 TECPR2 0.46 5.86 0.34 1.38e-8 Plateletcrit; CESC cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg03433033 chr1:76189801 ACADM -0.56 -6.06 -0.35 4.61e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs873946 0.689 rs2803993 chr10:134550606 T/C cg26818010 chr10:134567672 INPP5A -0.74 -9.04 -0.49 3.37e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6662572 0.737 rs4388641 chr1:46522326 A/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.25 0.31 3.12e-7 Blood protein levels; CESC cis rs4900538 0.819 rs72698591 chr14:102838896 G/A cg18135206 chr14:102964638 TECPR2 -0.74 -9.24 -0.49 8.19e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs2727020 0.521 rs10839296 chr11:49537617 T/C cg15704280 chr7:45808275 SEPT13 0.82 9.9 0.52 7.22e-20 Coronary artery disease; CESC cis rs7107174 0.901 rs7110387 chr11:78117875 A/G cg02023728 chr11:77925099 USP35 0.41 5.41 0.32 1.42e-7 Testicular germ cell tumor; CESC cis rs2290416 0.584 rs3816477 chr8:144685271 T/C cg17524265 chr8:144659883 NAPRT1 -0.52 -5.51 -0.32 8.57e-8 Attention deficit hyperactivity disorder; CESC trans rs7937682 0.855 rs11213985 chr11:111581521 C/A cg18187862 chr3:45730750 SACM1L 0.51 6.54 0.37 3.12e-10 Primary sclerosing cholangitis; CESC cis rs447 1.000 rs7781923 chr7:83747200 T/G cg22846510 chr7:83753280 SEMA3A -0.48 -5.87 -0.34 1.27e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9790314 0.871 rs336561 chr3:161125305 C/T cg03342759 chr3:160939853 NMD3 -0.44 -5.94 -0.34 8.85e-9 Morning vs. evening chronotype; CESC cis rs4148883 0.651 rs4147547 chr4:100127311 G/T cg12011299 chr4:100065546 ADH4 0.64 9.31 0.5 5.14e-18 Alcohol dependence; CESC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg18301423 chr5:131593218 PDLIM4 0.4 5.49 0.32 9.62e-8 Acylcarnitine levels; CESC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg04287289 chr16:89883240 FANCA 0.87 14.87 0.67 8.69e-37 Vitiligo; CESC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg23283495 chr1:209979779 IRF6 0.34 5.56 0.32 6.66e-8 Monobrow; CESC cis rs6736093 0.862 rs79798002 chr2:112733978 G/A cg12686935 chr2:112915763 FBLN7 -0.44 -5.72 -0.33 2.86e-8 Coronary artery disease; CESC cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg05340658 chr4:99064831 C4orf37 0.81 12.43 0.61 3.07e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9581857 0.615 rs9581848 chr13:28003997 C/T cg01674679 chr13:27998804 GTF3A -0.71 -5.67 -0.33 3.72e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs77741769 0.571 rs4454799 chr12:121317075 A/C cg02419362 chr12:121203948 SPPL3 -0.34 -5.53 -0.32 7.48e-8 Mean corpuscular volume; CESC cis rs4423214 1.000 rs909217 chr11:71146577 G/A cg05163923 chr11:71159392 DHCR7 0.75 10.16 0.53 1.07e-20 Vitamin D levels; CESC cis rs9796 0.870 rs3986311 chr15:41264339 C/G cg18705301 chr15:41695430 NDUFAF1 -0.47 -7.0 -0.4 2.08e-11 Menopause (age at onset); CESC cis rs2228479 0.850 rs17226966 chr16:89825338 A/G cg06558623 chr16:89946397 TCF25 1.17 9.38 0.5 3.19e-18 Skin colour saturation; CESC cis rs2204008 0.652 rs11513964 chr12:37998214 C/G cg13010199 chr12:38710504 ALG10B 0.53 6.63 0.38 1.87e-10 Bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00442658 chr21:18885041 CXADR 0.57 6.04 0.35 5.17e-9 Gut microbiome composition (summer); CESC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg26850624 chr5:429559 AHRR -0.49 -6.62 -0.38 1.94e-10 Cystic fibrosis severity; CESC cis rs8002861 0.846 rs12428314 chr13:44476011 C/T cg14210620 chr13:44453864 C13orf31;CCDC122 -0.42 -5.39 -0.31 1.58e-7 Leprosy; CESC cis rs11122272 0.735 rs2250749 chr1:231485763 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -7.43 -0.42 1.53e-12 Hemoglobin concentration; CESC cis rs2050392 0.624 rs303444 chr10:30729347 C/T cg25182066 chr10:30743637 MAP3K8 -0.45 -5.95 -0.34 8.61e-9 Inflammatory bowel disease; CESC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.6 0.33 5.26e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7208859 0.623 rs56163556 chr17:29101868 G/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10751667 0.621 rs7396107 chr11:970029 C/T cg06064525 chr11:970664 AP2A2 -0.47 -9.13 -0.49 1.8e-17 Alzheimer's disease (late onset); CESC cis rs72627123 0.867 rs73301485 chr14:74468643 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.8 5.77 0.33 2.2e-8 Morning vs. evening chronotype; CESC cis rs9611565 0.838 rs4239894 chr22:41745548 C/G cg03806693 chr22:41940476 POLR3H -1.0 -11.63 -0.58 1.52e-25 Vitiligo; CESC cis rs868036 1.000 rs1026733 chr15:68095122 G/A cg08079166 chr15:68083412 MAP2K5 0.44 6.94 0.39 2.94e-11 Restless legs syndrome; CESC trans rs561341 0.769 rs12941700 chr17:30185022 A/G cg27661571 chr11:113659931 NA 0.71 7.04 0.4 1.67e-11 Hip circumference adjusted for BMI; CESC cis rs9287719 0.967 rs6432113 chr2:10744889 C/T cg02196655 chr2:10830764 NOL10 0.36 5.55 0.32 6.89e-8 Prostate cancer; CESC cis rs9875589 0.509 rs9824910 chr3:14040136 C/T cg19554555 chr3:13937349 NA -0.44 -5.61 -0.33 4.98e-8 Ovarian reserve; CESC cis rs55882075 0.723 rs56227602 chr5:179179472 A/G cg14593053 chr5:179126677 CANX 0.55 8.07 0.44 2.51e-14 Monocyte percentage of white cells; CESC cis rs13242816 1.000 rs2024209 chr7:116135336 T/C cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC cis rs1879734 0.636 rs1879733 chr1:54175971 T/C cg23596471 chr1:54105337 GLIS1 0.32 5.17 0.3 4.7e-7 Mitral valve prolapse; CESC cis rs11785693 0.862 rs11774044 chr8:4988035 C/G cg26367366 chr8:4980734 NA 0.96 8.72 0.47 3.19e-16 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs7666738 0.791 rs28579101 chr4:98843203 T/C cg05340658 chr4:99064831 C4orf37 0.71 10.22 0.53 7.06e-21 Colonoscopy-negative controls vs population controls; CESC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg21770322 chr7:97807741 LMTK2 0.57 8.63 0.47 5.93e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs3857067 0.806 rs7654565 chr4:95112939 G/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.02 -0.48 3.78e-17 QT interval; CESC cis rs2296225 0.722 rs900038 chr1:21057552 C/A cg24673385 chr1:21051448 SH2D5 0.36 5.66 0.33 3.85e-8 Eosinophilic esophagitis; CESC trans rs9951602 0.512 rs6506874 chr18:76653467 G/T cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs7312933 1.000 rs7957213 chr12:42475438 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.38 5.05 0.3 8.32e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg21385522 chr1:16154831 NA 0.65 7.88 0.44 8.69e-14 Dilated cardiomyopathy; CESC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg05585544 chr11:47624801 NA 0.41 6.14 0.35 3.01e-9 Subjective well-being; CESC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg26335602 chr6:28129616 ZNF389 0.52 6.75 0.38 9.54e-11 Depression; CESC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg12463550 chr7:65579703 CRCP -0.57 -7.44 -0.42 1.43e-12 Aortic root size; CESC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg27170947 chr2:26402098 FAM59B -0.58 -6.91 -0.39 3.69e-11 Gut microbiome composition (summer); CESC cis rs644799 0.710 rs666398 chr11:95551136 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.76 10.93 0.56 3.47e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9549367 0.789 rs7994324 chr13:113906497 T/C cg00898013 chr13:113819073 PROZ -0.53 -7.31 -0.41 3.07e-12 Platelet distribution width; CESC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg17747265 chr1:1875780 NA -0.6 -9.76 -0.51 2.01e-19 Body mass index; CESC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg19717773 chr7:2847554 GNA12 -0.46 -6.48 -0.37 4.36e-10 Height; CESC cis rs7267979 1.000 rs6050559 chr20:25329915 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.84 16.6 0.71 6.47e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs9875589 0.509 rs4685051 chr3:13981760 A/G cg19554555 chr3:13937349 NA -0.43 -5.5 -0.32 8.87e-8 Ovarian reserve; CESC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg00815214 chr21:47717953 NA 0.43 6.27 0.36 1.49e-9 Testicular germ cell tumor; CESC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg11890956 chr21:40555474 PSMG1 0.97 16.62 0.71 5.65e-43 Cognitive function; CESC cis rs7267979 1.000 rs6076339 chr20:25348712 T/C cg08601574 chr20:25228251 PYGB -0.36 -5.19 -0.3 4.1e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs3780486 0.881 rs10738906 chr9:33135634 T/C cg13443165 chr9:33130375 B4GALT1 0.46 6.78 0.38 7.98e-11 IgG glycosylation; CESC cis rs72781680 0.611 rs7596820 chr2:24335036 G/C cg08917208 chr2:24149416 ATAD2B 0.56 5.49 0.32 9.59e-8 Lymphocyte counts; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27013455 chr14:102483114 DYNC1H1 0.44 6.01 0.35 6.21e-9 Fibrinogen levels; CESC cis rs7274811 0.656 rs293736 chr20:31925189 A/C cg21523528 chr20:32077966 CBFA2T2 -0.5 -5.62 -0.33 4.71e-8 Height; CESC cis rs10638925 1 rs10638925 chr3:194119749 C/CCATAAA cg00834899 chr3:194121120 GP5 0.58 9.65 0.51 4.34e-19 Platelet distribution width; CESC cis rs8072100 0.713 rs9895776 chr17:45486003 A/G cg25173405 chr17:45401733 C17orf57 -0.44 -5.48 -0.32 9.7e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg23622369 chr17:40706682 HSD17B1 -0.52 -7.68 -0.43 3.09e-13 Colorectal or endometrial cancer; CESC cis rs523522 0.962 rs10849754 chr12:120940418 A/C cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs763014 0.931 rs10903017 chr16:627920 T/C cg00908189 chr16:619842 PIGQ 0.67 9.39 0.5 2.81e-18 Height; CESC cis rs10411936 0.712 rs8103486 chr19:16603107 A/G cg10248733 chr19:16607483 C19orf44;CALR3 0.57 6.74 0.38 9.66e-11 White blood cell count;Multiple sclerosis; CESC trans rs61931739 0.500 rs11053222 chr12:34481100 C/A cg26384229 chr12:38710491 ALG10B 0.7 10.6 0.55 3.94e-22 Morning vs. evening chronotype; CESC cis rs13256369 0.802 rs11995449 chr8:8559898 G/A cg00074818 chr8:8560427 CLDN23 0.38 5.32 0.31 2.24e-7 Obesity-related traits; CESC cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg25427524 chr10:38739819 LOC399744 -0.66 -9.51 -0.5 1.22e-18 Extrinsic epigenetic age acceleration; CESC trans rs9467711 0.720 rs9348716 chr6:26375658 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -6.67 -0.38 1.48e-10 Autism spectrum disorder or schizophrenia; CESC cis rs1670533 0.818 rs585735 chr4:1080391 G/C cg27284194 chr4:1044797 NA 0.48 6.07 0.35 4.52e-9 Recombination rate (females); CESC trans rs17685 0.753 rs2302438 chr7:75677065 C/A cg19862616 chr7:65841803 NCRNA00174 0.82 11.95 0.59 1.27e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs909674 0.514 rs7423 chr22:39781429 C/T cg05872129 chr22:39784769 NA -0.73 -10.5 -0.54 8.56e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs1153858 1.000 rs7179743 chr15:45638331 G/C cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs9314323 0.767 rs13271042 chr8:26190212 T/G cg13160058 chr8:26243215 BNIP3L -0.35 -5.25 -0.31 3.15e-7 Red cell distribution width; CESC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.86 12.8 0.62 1.6e-29 Prudent dietary pattern; CESC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg20307385 chr11:47447363 PSMC3 -0.54 -6.4 -0.37 7.03e-10 Subjective well-being; CESC cis rs7809950 0.731 rs4730238 chr7:107054787 G/A cg23024343 chr7:107201750 COG5 -0.58 -7.43 -0.42 1.49e-12 Coronary artery disease; CESC cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg02297831 chr4:17616191 MED28 0.53 6.66 0.38 1.6e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg02951883 chr7:2050386 MAD1L1 -0.49 -6.34 -0.36 1e-9 Bipolar disorder and schizophrenia; CESC cis rs12995491 0.933 rs34366691 chr2:88537451 G/A cg07952391 chr2:88470173 THNSL2 -0.55 -8.4 -0.46 2.72e-15 Response to metformin (IC50); CESC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.89 -12.56 -0.61 1.02e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4843747 0.708 rs11866437 chr16:88072279 A/G cg17633681 chr16:88106987 BANP -0.61 -8.22 -0.45 9.07e-15 Menopause (age at onset); CESC cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg00033643 chr7:134001901 SLC35B4 0.4 5.03 0.3 9.21e-7 Mean platelet volume; CESC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg25517755 chr10:38738941 LOC399744 -0.46 -5.88 -0.34 1.22e-8 Breast cancer; CESC cis rs644799 1.000 rs474442 chr11:95583995 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 14.15 0.66 3.04e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs8114671 0.562 rs6058120 chr20:33402829 A/G cg07148914 chr20:33460835 GGT7 0.44 5.73 0.33 2.68e-8 Height; CESC cis rs3857067 1.000 rs7694820 chr4:95017026 G/A cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.05e-14 QT interval; CESC cis rs12893668 0.645 rs35229468 chr14:104052057 C/T cg24130564 chr14:104152367 KLC1 -0.48 -6.01 -0.35 6.16e-9 Reticulocyte count; CESC cis rs7666738 0.830 rs13124904 chr4:98856973 T/C cg17366294 chr4:99064904 C4orf37 0.55 7.72 0.43 2.38e-13 Colonoscopy-negative controls vs population controls; CESC cis rs8058578 1.000 rs7187359 chr16:30703155 G/A cg00531865 chr16:30841666 NA -0.44 -5.84 -0.34 1.51e-8 Multiple myeloma; CESC cis rs7100689 0.646 rs10749581 chr10:82141651 A/G cg00277334 chr10:82204260 NA 0.55 7.1 0.4 1.12e-11 Post bronchodilator FEV1; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02957340 chr14:100070899 CCDC85C -0.46 -6.26 -0.36 1.56e-9 Fibrinogen levels; CESC cis rs3540 0.554 rs34650360 chr15:91059017 T/C cg22089800 chr15:90895588 ZNF774 -0.61 -8.09 -0.44 2.17e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs7044106 0.708 rs991121 chr9:123370345 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.78 11.61 0.58 1.85e-25 Hip circumference adjusted for BMI; CESC cis rs2228479 0.850 rs11639906 chr16:89798183 T/C cg00800038 chr16:89945340 TCF25 -0.74 -5.68 -0.33 3.6e-8 Skin colour saturation; CESC cis rs17376456 0.741 rs7718842 chr5:93480568 G/A cg25358565 chr5:93447407 FAM172A 1.2 10.97 0.56 2.47e-23 Diabetic retinopathy; CESC cis rs1124376 1.000 rs12488369 chr3:20154059 G/T cg05072819 chr3:20081367 KAT2B -0.46 -5.09 -0.3 6.86e-7 Bipolar disorder and schizophrenia; CESC cis rs7208859 0.573 rs56031503 chr17:29075665 T/C cg19761014 chr17:28927070 LRRC37B2 0.76 6.33 0.36 1.02e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg01097406 chr16:89675127 NA -0.33 -5.06 -0.3 7.88e-7 Vitiligo; CESC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg10691866 chr7:65817282 TPST1 -0.31 -5.1 -0.3 6.47e-7 Aortic root size; CESC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg06494592 chr3:125709126 NA -0.52 -5.56 -0.32 6.58e-8 Blood pressure (smoking interaction); CESC trans rs9929218 1.000 rs17772363 chr16:68788909 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.72 -9.18 -0.49 1.29e-17 Colorectal cancer; CESC cis rs2180341 0.782 rs6569490 chr6:127729615 C/T cg24812749 chr6:127587940 RNF146 0.84 12.05 0.59 5.93e-27 Breast cancer; CESC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg20607287 chr7:12443886 VWDE -0.67 -9.67 -0.51 3.97e-19 Coronary artery disease; CESC cis rs11864453 0.647 rs7194397 chr16:72128299 C/T cg01557791 chr16:72042693 DHODH -0.43 -5.49 -0.32 9.35e-8 Fibrinogen levels; CESC cis rs477692 0.967 rs519690 chr10:131424033 G/A cg05714579 chr10:131428358 MGMT 0.48 6.49 0.37 4.29e-10 Response to temozolomide; CESC cis rs7246657 0.941 rs10418729 chr19:37737065 A/C cg23950597 chr19:37808831 NA -0.6 -6.43 -0.37 5.86e-10 Coronary artery calcification; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27605355 chr17:74472963 RHBDF2 -0.6 -7.52 -0.42 8.73e-13 Gut microbiome composition (summer); CESC trans rs6445797 0.821 rs11714897 chr3:56666148 G/C cg15444621 chr13:113611794 NA 0.32 6.01 0.35 6.11e-9 Gastritis; CESC trans rs1814175 0.619 rs10769623 chr11:49865926 C/T cg15704280 chr7:45808275 SEPT13 -0.98 -18.32 -0.75 5.46e-49 Height; CESC cis rs8005677 0.926 rs34344888 chr14:23387585 A/G cg25600027 chr14:23388339 RBM23 -0.43 -5.33 -0.31 2.08e-7 Cognitive ability (multi-trait analysis); CESC cis rs7714584 1.000 rs73282255 chr5:150223647 A/T cg22134413 chr5:150180641 NA 0.53 5.75 0.33 2.47e-8 Crohn's disease; CESC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg17971929 chr21:40555470 PSMG1 -0.85 -12.27 -0.6 1.02e-27 Cognitive function; CESC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -5.76 -0.33 2.29e-8 Extrinsic epigenetic age acceleration; CESC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.64 -0.33 4.41e-8 Menopause (age at onset); CESC cis rs8141529 0.509 rs7287124 chr22:29239157 A/G cg02153584 chr22:29168773 CCDC117 0.59 7.66 0.43 3.42e-13 Lymphocyte counts; CESC cis rs711245 0.573 rs3770796 chr2:36799515 T/C cg01206211 chr2:36825736 FEZ2 0.32 5.15 0.3 5.02e-7 Height; CESC cis rs758324 0.947 rs72793241 chr5:131240885 C/T cg06307176 chr5:131281290 NA -0.43 -5.16 -0.3 4.84e-7 Alzheimer's disease in APOE e4- carriers; CESC cis rs561341 1.000 rs537166 chr17:30326827 C/T cg00745463 chr17:30367425 LRRC37B -0.68 -6.81 -0.39 6.34e-11 Hip circumference adjusted for BMI; CESC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg13126279 chr21:47581558 C21orf56 0.47 6.41 0.37 6.65e-10 Testicular germ cell tumor; CESC cis rs672059 0.806 rs3754524 chr1:183153267 C/T ch.1.3577855R chr1:183094577 LAMC1 0.49 5.97 0.34 7.45e-9 Hypertriglyceridemia; CESC trans rs9951602 1.000 rs1903723 chr18:76646571 A/G cg02800362 chr5:177631904 HNRNPAB 0.61 6.74 0.38 9.92e-11 Obesity-related traits; CESC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs344364 0.518 rs1657129 chr16:1945826 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs6754311 0.638 rs2322659 chr2:136555659 A/G cg15123519 chr2:136567270 LCT 0.29 5.03 0.3 9.15e-7 Mosquito bite size; CESC cis rs11679564 0.714 rs4016031 chr2:37184754 C/T cg14987922 chr2:37194071 STRN 0.42 5.26 0.31 3.02e-7 Immature fraction of reticulocytes; CESC cis rs8114671 0.836 rs13042358 chr20:33634479 G/A cg07148914 chr20:33460835 GGT7 -0.41 -5.31 -0.31 2.28e-7 Height; CESC cis rs5769765 0.837 rs4824110 chr22:50271631 T/A cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC trans rs9354308 0.933 rs2022856 chr6:66568235 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 7.96 0.44 5.21e-14 Metabolite levels; CESC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg19622623 chr12:86230825 RASSF9 -0.47 -6.04 -0.35 5.17e-9 Major depressive disorder; CESC cis rs11864453 0.647 rs2550035 chr16:72113416 C/G cg16558253 chr16:72132732 DHX38 -0.51 -8.02 -0.44 3.35e-14 Fibrinogen levels; CESC cis rs16895831 0.519 rs4379287 chr6:42592486 T/C cg10605015 chr6:42532144 UBR2 0.52 5.91 0.34 1.07e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg23281280 chr6:28129359 ZNF389 0.5 6.97 0.39 2.44e-11 Depression; CESC cis rs6120849 0.707 rs6088690 chr20:33633326 A/G cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs34779708 0.966 rs12775548 chr10:35479504 G/T cg04310649 chr10:35416472 CREM -0.49 -5.81 -0.34 1.82e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs13253111 0.624 rs35990565 chr8:28107815 C/T cg26534493 chr8:28060551 NA 0.45 6.73 0.38 1.06e-10 Childhood body mass index; CESC cis rs1832871 0.672 rs7745596 chr6:158732991 T/A cg07165851 chr6:158734300 TULP4 0.6 6.58 0.37 2.57e-10 Height; CESC cis rs9303401 0.659 rs17822807 chr17:56687190 A/C cg02118635 chr17:56770003 RAD51C;TEX14 1.0 11.58 0.58 2.27e-25 Cognitive test performance; CESC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg11890956 chr21:40555474 PSMG1 1.21 24.6 0.83 2.29e-70 Cognitive function; CESC cis rs4595586 0.546 rs10876163 chr12:39244915 G/A cg26384229 chr12:38710491 ALG10B 0.68 10.21 0.53 7.56e-21 Morning vs. evening chronotype; CESC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg06481639 chr22:41940642 POLR3H -0.62 -6.49 -0.37 4.27e-10 Vitiligo; CESC cis rs6430585 0.702 rs2015532 chr2:136555525 G/T cg07169764 chr2:136633963 MCM6 -1.24 -16.85 -0.72 8.49e-44 Corneal structure; CESC cis rs3820928 1.000 rs6723774 chr2:227770592 C/T cg11843606 chr2:227700838 RHBDD1 0.42 5.5 0.32 9e-8 Pulmonary function; CESC cis rs9303401 0.580 rs2013166 chr17:56637630 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.93 0.62 5.59e-30 Cognitive test performance; CESC cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg24308560 chr3:49941425 MST1R 0.58 8.31 0.45 5.15e-15 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02670133 chr5:65440111 SFRS12 0.56 6.4 0.37 7.2e-10 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06476606 chr10:91061728 IFIT2 -0.44 -6.43 -0.37 6.06e-10 Gambling; CESC cis rs11711311 1.000 rs12636577 chr3:113497507 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.73 10.3 0.53 3.78e-21 IgG glycosylation; CESC cis rs62229266 0.804 rs880221 chr21:37420785 C/T cg12218747 chr21:37451666 NA -0.43 -6.09 -0.35 3.99e-9 Mitral valve prolapse; CESC cis rs4843747 0.671 rs8053377 chr16:88106465 A/G cg03395651 chr16:88107091 BANP 0.47 5.46 0.32 1.1e-7 Menopause (age at onset); CESC cis rs7085104 0.632 rs7096475 chr10:104609676 A/G cg15744005 chr10:104629667 AS3MT -0.32 -5.19 -0.3 4.1e-7 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs10479542 0.929 rs10078796 chr5:178978883 T/A cg14820908 chr5:178986412 RUFY1 0.47 7.18 0.4 6.86e-12 Lung cancer; CESC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg25036284 chr2:26402008 FAM59B -0.59 -6.9 -0.39 3.85e-11 Gut microbiome composition (summer); CESC cis rs4925386 0.559 rs2427291 chr20:60921324 G/A cg22601191 chr20:60968625 CABLES2 0.53 5.26 0.31 2.92e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg15556689 chr8:8085844 FLJ10661 -0.54 -6.97 -0.39 2.49e-11 Neuroticism; CESC trans rs7246760 0.748 rs73006398 chr19:9723447 A/G cg02900749 chr2:68251473 NA -0.79 -6.02 -0.35 5.78e-9 Pursuit maintenance gain; CESC cis rs7671266 0.668 rs6834055 chr4:10158511 A/T cg11266682 chr4:10021025 SLC2A9 -0.47 -5.96 -0.34 7.83e-9 Cardiovascular disease risk factors; CESC cis rs12477438 0.501 rs6751927 chr2:99740175 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.18 0.68 6.85e-38 Chronic sinus infection; CESC cis rs6142102 0.602 rs4911380 chr20:32546224 C/T cg08999081 chr20:33150536 PIGU 0.34 5.12 0.3 5.93e-7 Skin pigmentation; CESC cis rs11958404 0.860 rs72818114 chr5:157440207 A/C cg05962755 chr5:157440814 NA 0.59 6.52 0.37 3.45e-10 IgG glycosylation; CESC cis rs2204008 0.744 rs11168870 chr12:37973333 A/G cg26384229 chr12:38710491 ALG10B 0.74 10.84 0.55 6.46e-23 Bladder cancer; CESC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg26314531 chr2:26401878 FAM59B 0.85 9.23 0.49 8.65e-18 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03747177 chr16:23568683 EARS2;UBFD1 0.48 6.04 0.35 5.22e-9 Gut microbiota (bacterial taxa); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05655935 chr10:93683722 BTAF1 -0.51 -7.09 -0.4 1.24e-11 Fibrinogen levels; CESC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg16545954 chr1:2118288 C1orf86 -0.32 -6.17 -0.35 2.55e-9 Height; CESC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.65 9.43 0.5 2.1e-18 Menarche (age at onset); CESC cis rs35146811 0.586 rs6946168 chr7:99598286 C/T cg14163444 chr7:99595348 NA -0.39 -5.13 -0.3 5.57e-7 Coronary artery disease; CESC cis rs6674176 0.660 rs6680421 chr1:44408969 A/C cg13606994 chr1:44402422 ARTN 0.4 6.17 0.35 2.52e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.55 -0.32 6.9e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9790314 0.934 rs461638 chr3:161103166 A/G cg03342759 chr3:160939853 NMD3 -0.45 -5.87 -0.34 1.29e-8 Morning vs. evening chronotype; CESC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg11764359 chr7:65958608 NA 0.96 15.23 0.68 4.78e-38 Aortic root size; CESC cis rs9443645 0.527 rs3902856 chr6:79699837 C/T cg05283184 chr6:79620031 NA -0.37 -5.26 -0.31 2.91e-7 Intelligence (multi-trait analysis); CESC cis rs5758659 1.000 rs5758660 chr22:42623718 C/A cg04733989 chr22:42467013 NAGA 0.41 5.67 0.33 3.8e-8 Cognitive function; CESC cis rs4595586 0.525 rs11612680 chr12:39344443 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.2e-8 Morning vs. evening chronotype; CESC cis rs2228479 0.702 rs62053702 chr16:89860688 G/T cg19635926 chr16:89946313 TCF25 0.68 5.17 0.3 4.65e-7 Skin colour saturation; CESC cis rs2439831 0.702 rs7175032 chr15:44060236 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.72 6.81 0.39 6.65e-11 Lung cancer in ever smokers; CESC cis rs35110281 0.840 rs2838331 chr21:45026728 A/G cg21573476 chr21:45109991 RRP1B 0.46 6.4 0.37 6.98e-10 Mean corpuscular volume; CESC cis rs7267979 0.586 rs6037057 chr20:25182089 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.67 10.88 0.56 4.73e-23 Liver enzyme levels (alkaline phosphatase); CESC trans rs10242455 0.702 rs73405247 chr7:99159174 C/G cg09045935 chr12:6379348 NA 0.91 6.98 0.39 2.36e-11 Blood metabolite levels; CESC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg03806693 chr22:41940476 POLR3H -1.14 -14.12 -0.66 3.81e-34 Vitiligo; CESC cis rs863345 1.000 rs863345 chr1:158534982 A/G cg12129480 chr1:158549410 OR10X1 0.32 6.42 0.37 6.09e-10 Pneumococcal bacteremia; CESC trans rs1814175 0.745 rs7483456 chr11:49774613 C/T cg03929089 chr4:120376271 NA -0.9 -14.97 -0.68 4.06e-37 Height; CESC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.42 0.41 1.61e-12 Tonsillectomy; CESC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg22800045 chr5:56110881 MAP3K1 -0.8 -9.64 -0.51 4.78e-19 Initial pursuit acceleration; CESC cis rs4835473 0.897 rs1450246 chr4:144624107 A/T cg25736465 chr4:144833511 NA 0.36 5.48 0.32 9.68e-8 Immature fraction of reticulocytes; CESC cis rs7100689 0.577 rs2282367 chr10:82040346 A/G cg09936400 chr10:82049201 MAT1A 0.4 6.18 0.36 2.36e-9 Post bronchodilator FEV1; CESC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg05754148 chr16:3507555 NAT15 -0.64 -6.36 -0.36 8.93e-10 Tuberculosis; CESC cis rs1707322 0.717 rs1972410 chr1:46080947 G/T cg06784218 chr1:46089804 CCDC17 0.41 7.14 0.4 9.22e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10927875 1.000 rs12138117 chr1:16305279 T/C cg22431228 chr1:16359049 CLCNKA 0.37 5.73 0.33 2.74e-8 Dilated cardiomyopathy; CESC trans rs11148252 0.500 rs342768 chr13:53208882 C/T cg18335740 chr13:41363409 SLC25A15 0.56 7.96 0.44 4.95e-14 Lewy body disease; CESC cis rs7944584 0.655 rs11039183 chr11:47346940 G/A cg20307385 chr11:47447363 PSMC3 0.69 8.84 0.48 1.39e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CESC cis rs1545257 0.505 rs7583687 chr2:24634003 C/G cg06627628 chr2:24431161 ITSN2 -0.47 -5.76 -0.33 2.38e-8 Sjögren's syndrome; CESC trans rs116095464 0.558 rs13357299 chr5:242211 T/C cg00938859 chr5:1591904 SDHAP3 0.63 6.98 0.39 2.3e-11 Breast cancer; CESC cis rs684232 0.602 rs331008 chr17:544617 C/T cg15660573 chr17:549704 VPS53 -0.8 -11.67 -0.58 1.16e-25 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06725705 chr16:9058264 USP7 0.6 6.91 0.39 3.65e-11 Gut microbiome composition (summer); CESC cis rs9858542 1.000 rs13085791 chr3:49721798 C/A cg03060546 chr3:49711283 APEH -0.58 -6.87 -0.39 4.44e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4237845 0.537 rs12312955 chr12:58265223 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.49 5.46 0.32 1.12e-7 Intelligence (multi-trait analysis); CESC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg26335602 chr6:28129616 ZNF389 0.48 6.52 0.37 3.56e-10 Depression; CESC cis rs6430585 0.528 rs309172 chr2:136674028 A/G cg07169764 chr2:136633963 MCM6 1.16 16.89 0.72 5.92e-44 Corneal structure; CESC trans rs1814175 0.791 rs1722011 chr11:49899340 G/C cg15704280 chr7:45808275 SEPT13 -1.03 -21.02 -0.79 2.09e-58 Height; CESC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg17294928 chr15:75287854 SCAMP5 0.52 6.66 0.38 1.62e-10 Breast cancer; CESC cis rs1983891 0.955 rs4714480 chr6:41520891 T/C cg20194872 chr6:41519635 FOXP4 0.57 8.19 0.45 1.12e-14 Prostate cancer; CESC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg22535103 chr8:58192502 C8orf71 -0.95 -9.78 -0.51 1.78e-19 Developmental language disorder (linguistic errors); CESC cis rs2228479 1.000 rs11642267 chr16:89957635 T/C cg04013166 chr16:89971882 TCF25 0.76 6.53 0.37 3.28e-10 Skin colour saturation; CESC cis rs116095464 0.558 rs1812843 chr5:267658 A/G cg20965017 chr5:231967 SDHA -0.48 -5.43 -0.32 1.25e-7 Breast cancer; CESC cis rs72781680 0.716 rs7564732 chr2:24034178 C/T cg08917208 chr2:24149416 ATAD2B 0.65 6.34 0.36 9.82e-10 Lymphocyte counts; CESC cis rs897984 0.762 rs2305880 chr16:30999462 T/C cg00531865 chr16:30841666 NA 0.5 6.87 0.39 4.7e-11 Dementia with Lewy bodies; CESC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 11.2 0.57 4.36e-24 Platelet count; CESC cis rs9549367 0.713 rs1755690 chr13:113824266 T/C cg00898013 chr13:113819073 PROZ 0.45 6.62 0.38 1.97e-10 Platelet distribution width; CESC cis rs16937 0.518 rs1172149 chr1:205224758 A/G cg21643547 chr1:205240462 TMCC2 -0.32 -5.04 -0.3 8.5e-7 Schizophrenia; CESC cis rs17253792 0.822 rs10145687 chr14:56124384 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.78 0.33 2.08e-8 Putamen volume; CESC cis rs9815354 0.951 rs1619558 chr3:41914213 C/G cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC trans rs6460942 0.556 rs2287067 chr7:12370533 T/C cg16269144 chr1:2003326 PRKCZ 0.51 6.21 0.36 2e-9 Coronary artery disease; CESC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.16 0.4 8.18e-12 Electroencephalogram traits; CESC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg12311346 chr5:56204834 C5orf35 -0.72 -8.75 -0.47 2.48e-16 Initial pursuit acceleration; CESC cis rs9790314 1.000 rs336590 chr3:161079583 G/A cg03342759 chr3:160939853 NMD3 -0.5 -6.45 -0.37 5.33e-10 Morning vs. evening chronotype; CESC cis rs6912958 0.781 rs9444522 chr6:88309705 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.07 -0.3 7.4e-7 Monocyte percentage of white cells; CESC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.38 -6.14 -0.35 2.97e-9 Cystic fibrosis severity; CESC cis rs79349575 0.691 rs28528789 chr17:46986616 C/T cg16584676 chr17:46985605 UBE2Z -0.71 -9.25 -0.49 8.03e-18 Type 2 diabetes; CESC cis rs1348850 0.526 rs10497504 chr2:178370040 T/C cg22681709 chr2:178499509 PDE11A -0.5 -5.16 -0.3 4.97e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs75229567 0.618 rs1599745 chr12:70186029 A/G cg10114359 chr12:70132523 RAB3IP 0.78 6.08 0.35 4.08e-9 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs17401966 1.000 rs17411502 chr1:10431158 T/C cg15208524 chr1:10270712 KIF1B 0.46 5.77 0.33 2.2e-8 Hepatocellular carcinoma; CESC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg07701084 chr6:150067640 NUP43 0.43 5.77 0.33 2.2e-8 Lung cancer; CESC cis rs896543 0.702 rs12692190 chr2:237496190 C/T cg25295825 chr2:237489920 CXCR7 0.7 9.68 0.51 3.57e-19 Alcohol dependence (age at onset); CESC trans rs1728785 0.792 rs1111502 chr16:68581209 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.42 1.04e-12 Ulcerative colitis; CESC cis rs561341 1.000 rs15654 chr17:30326360 A/C cg00745463 chr17:30367425 LRRC37B -0.82 -7.51 -0.42 9.09e-13 Hip circumference adjusted for BMI; CESC cis rs9902453 0.967 rs4473252 chr17:28454423 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 8.02 0.44 3.41e-14 Coffee consumption (cups per day); CESC cis rs701145 0.586 rs181443 chr3:153959028 G/T cg16511985 chr3:153974050 SGEF 0.46 6.25 0.36 1.66e-9 Coronary artery disease; CESC trans rs853679 0.546 rs175597 chr6:27810626 T/C cg06606381 chr12:133084897 FBRSL1 -0.82 -7.72 -0.43 2.38e-13 Depression; CESC cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg00701064 chr4:6280414 WFS1 -0.69 -12.24 -0.6 1.34e-27 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs6088590 0.550 rs12624640 chr20:32952125 G/A cg08999081 chr20:33150536 PIGU 0.56 8.53 0.46 1.15e-15 Coronary artery disease; CESC cis rs6987853 0.686 rs10087350 chr8:42359484 G/A cg09913449 chr8:42400586 C8orf40 -0.36 -5.92 -0.34 9.91e-9 Mean corpuscular hemoglobin concentration; CESC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg02487422 chr3:49467188 NICN1 0.38 5.26 0.31 2.98e-7 Menarche (age at onset); CESC trans rs2502399 0.652 rs2502370 chr6:113509611 G/A cg00285294 chr7:1089767 C7orf50 -0.34 -6.33 -0.36 1.06e-9 Plasma clusterin levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg00320862 chr3:170588302 RPL22L1 -0.5 -6.5 -0.37 4.02e-10 Ulcerative colitis; CESC cis rs12586317 0.547 rs77780729 chr14:35496176 C/A cg05294307 chr14:35346193 BAZ1A -0.58 -5.96 -0.34 7.85e-9 Psoriasis; CESC cis rs7267979 0.933 rs1130694 chr20:25276297 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 16.93 0.72 4.47e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs7100689 0.646 rs1953972 chr10:82145666 A/G cg00277334 chr10:82204260 NA -0.58 -7.62 -0.42 4.52e-13 Post bronchodilator FEV1; CESC cis rs763121 0.853 rs5757196 chr22:39039855 G/C cg06544989 chr22:39130855 UNC84B 0.5 8.66 0.47 4.63e-16 Menopause (age at onset); CESC cis rs9905704 0.681 rs7225128 chr17:56636854 T/C cg12560992 chr17:57184187 TRIM37 -0.63 -5.87 -0.34 1.3e-8 Testicular germ cell tumor; CESC cis rs208520 0.690 rs1776365 chr6:66834474 G/T cg07460842 chr6:66804631 NA -0.98 -13.25 -0.63 4.4e-31 Exhaled nitric oxide output; CESC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.08 11.23 0.57 3.45e-24 Platelet count; CESC cis rs72615157 0.539 rs4729575 chr7:99686873 G/T cg22004693 chr7:99632812 ZKSCAN1 0.43 5.31 0.31 2.3e-7 Lung function (FEV1/FVC); CESC cis rs6087990 0.735 rs2064350 chr20:31390533 T/C cg13636640 chr20:31349939 DNMT3B 0.8 12.86 0.62 9.44e-30 Ulcerative colitis; CESC cis rs8060686 0.545 rs3826164 chr16:68280317 A/G cg26727032 chr16:67993705 SLC12A4 0.51 5.49 0.32 9.44e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg12463550 chr7:65579703 CRCP 0.49 6.35 0.36 9.51e-10 Aortic root size; CESC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.19 0.53 8.92e-21 Mean platelet volume; CESC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.5 -0.54 8.72e-22 Alzheimer's disease; CESC cis rs295140 0.546 rs842830 chr2:201131124 C/T cg23649088 chr2:200775458 C2orf69 -0.46 -6.14 -0.35 3.06e-9 QT interval; CESC cis rs6933660 0.800 rs2046371 chr6:151754744 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.8 12.3 0.6 7.99e-28 Menarche (age at onset); CESC trans rs875971 1.000 rs7781698 chr7:65896312 A/T cg26939375 chr7:64535504 NA 0.48 6.24 0.36 1.68e-9 Aortic root size; CESC cis rs7666738 0.830 rs13133355 chr4:98919415 A/G cg17366294 chr4:99064904 C4orf37 0.57 8.0 0.44 3.83e-14 Colonoscopy-negative controls vs population controls; CESC cis rs2777491 0.957 rs7163788 chr15:41704789 A/G cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.82 -0.52 1.26e-19 Ulcerative colitis; CESC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg04518342 chr5:131593106 PDLIM4 -0.36 -5.21 -0.3 3.8e-7 Blood metabolite levels; CESC cis rs3820928 0.874 rs1114562 chr2:227788592 T/C cg11843606 chr2:227700838 RHBDD1 -0.49 -6.59 -0.38 2.33e-10 Pulmonary function; CESC cis rs116095464 1.000 rs56075848 chr5:308352 T/C cg22857025 chr5:266934 NA -1.2 -10.27 -0.53 4.88e-21 Breast cancer; CESC cis rs2836633 1.000 rs2836633 chr21:40067445 C/T cg05519781 chr21:40033154 ERG -0.61 -9.74 -0.51 2.33e-19 Coronary artery disease; CESC cis rs7267979 0.903 rs6107015 chr20:25216764 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 14.91 0.68 6.25e-37 Liver enzyme levels (alkaline phosphatase); CESC cis rs763121 0.853 rs3788545 chr22:39065172 A/G cg06022373 chr22:39101656 GTPBP1 0.88 13.88 0.65 2.66e-33 Menopause (age at onset); CESC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg24675658 chr1:53192096 ZYG11B -0.5 -6.23 -0.36 1.79e-9 Monocyte count; CESC cis rs6752107 0.967 rs3816234 chr2:234185999 G/A cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.39 5.91 0.34 1.07e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg17971929 chr21:40555470 PSMG1 0.86 12.8 0.62 1.53e-29 Cognitive function; CESC cis rs2797160 1.000 rs1739367 chr6:126004720 G/T cg05901451 chr6:126070800 HEY2 -0.45 -6.53 -0.37 3.43e-10 Endometrial cancer; CESC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg10691866 chr7:65817282 TPST1 -0.34 -5.6 -0.33 5.45e-8 Aortic root size; CESC cis rs7219021 0.961 rs7215901 chr17:46858083 A/C cg16584676 chr17:46985605 UBE2Z -0.71 -7.92 -0.44 6.57e-14 Schizophrenia or bipolar disorder; CESC cis rs7772486 0.875 rs9373485 chr6:146401429 A/T cg23711669 chr6:146136114 FBXO30 0.84 12.73 0.62 2.75e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg15445000 chr17:37608096 MED1 -0.4 -6.54 -0.37 3.14e-10 Glomerular filtration rate (creatinine); CESC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg06484146 chr7:12443880 VWDE -0.66 -9.48 -0.5 1.53e-18 Coronary artery disease; CESC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.2 0.53 7.77e-21 Mean platelet volume; CESC cis rs72792276 1.000 rs17164395 chr5:127395526 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.68 5.25 0.31 3.14e-7 Red cell distribution width; CESC cis rs897984 0.683 rs12926237 chr16:30837596 C/T cg02466173 chr16:30829666 NA 0.59 11.07 0.56 1.17e-23 Dementia with Lewy bodies; CESC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -6.71 -0.38 1.19e-10 Bipolar disorder; CESC cis rs7044106 0.718 rs10616 chr9:123363533 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 9.88 0.52 8.58e-20 Hip circumference adjusted for BMI; CESC cis rs2295499 0.673 rs73189408 chr4:2705644 T/A cg27239842 chr4:2403781 ZFYVE28 -0.33 -5.6 -0.33 5.29e-8 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs763121 0.853 rs2072794 chr22:39150543 G/T cg06022373 chr22:39101656 GTPBP1 0.93 15.31 0.69 2.49e-38 Menopause (age at onset); CESC cis rs6088580 0.634 rs4911419 chr20:32995873 G/A cg08999081 chr20:33150536 PIGU -0.65 -11.29 -0.57 2.22e-24 Glomerular filtration rate (creatinine); CESC cis rs763121 0.853 rs2294296 chr22:39053049 T/C cg21395723 chr22:39101663 GTPBP1 0.43 5.37 0.31 1.76e-7 Menopause (age at onset); CESC cis rs2952156 0.834 rs903503 chr17:37829571 C/A cg07936489 chr17:37558343 FBXL20 -0.59 -7.52 -0.42 8.39e-13 Asthma; CESC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg11494091 chr17:61959527 GH2 0.73 12.48 0.61 2.02e-28 Prudent dietary pattern; CESC cis rs55883249 0.957 rs17362839 chr2:9754439 T/C cg23886495 chr2:9695866 ADAM17 0.65 5.89 0.34 1.19e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg13770153 chr20:60521292 NA -0.47 -6.01 -0.35 6.03e-9 Body mass index; CESC cis rs6570726 0.935 rs380883 chr6:145822992 A/G cg23711669 chr6:146136114 FBXO30 0.79 11.45 0.58 6.2e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs2425143 0.818 rs11700299 chr20:34548865 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.13 -0.4 9.32e-12 Blood protein levels; CESC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg06808227 chr14:105710500 BRF1 -0.6 -7.15 -0.4 8.26e-12 Mean platelet volume;Platelet distribution width; CESC cis rs2777491 0.872 rs7176588 chr15:41588872 C/T cg20272979 chr15:41787780 ITPKA 0.34 5.05 0.3 8.08e-7 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25371950 chr2:242786524 NA 0.58 6.63 0.38 1.91e-10 Gut microbiome composition (summer); CESC cis rs1008375 0.966 rs6839660 chr4:17667987 C/T cg02297831 chr4:17616191 MED28 0.46 5.81 0.34 1.81e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.04 -0.56 1.41e-23 Alzheimer's disease; CESC cis rs72792276 1.000 rs10519971 chr5:127379216 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.74 -5.97 -0.34 7.57e-9 Red cell distribution width; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24623068 chr5:154317667 GEMIN5 -0.41 -6.2 -0.36 2.19e-9 Gambling; CESC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg14703610 chr5:56206110 C5orf35 0.46 6.15 0.35 2.86e-9 Breast cancer;Breast cancer (early onset); CESC cis rs6121246 0.865 rs6089055 chr20:30324045 C/T cg13852791 chr20:30311386 BCL2L1 0.82 7.64 0.42 3.91e-13 Mean corpuscular hemoglobin; CESC cis rs2228479 0.717 rs2270460 chr16:89972416 C/A cg06558623 chr16:89946397 TCF25 0.91 8.02 0.44 3.45e-14 Skin colour saturation; CESC cis rs965469 0.779 rs6133034 chr20:3337661 A/G cg17110299 chr20:3385021 C20orf194 0.4 5.26 0.31 3.02e-7 IFN-related cytopenia; CESC cis rs796364 0.806 rs203769 chr2:200900866 C/T cg23649088 chr2:200775458 C2orf69 -0.58 -5.35 -0.31 1.86e-7 Schizophrenia; CESC trans rs1814175 0.645 rs1721997 chr11:49916653 T/C cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs1707322 0.721 rs11211157 chr1:46132844 T/C cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg00149659 chr3:10157352 C3orf10 0.7 8.64 0.47 5.25e-16 Alzheimer's disease; CESC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg04756594 chr16:24857601 SLC5A11 -0.45 -5.55 -0.32 7.01e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg02725872 chr8:58115012 NA -0.43 -6.81 -0.39 6.53e-11 Developmental language disorder (linguistic errors); CESC cis rs17253792 0.545 rs75276278 chr14:56024341 C/T cg01858014 chr14:56050164 KTN1 -0.88 -6.38 -0.36 7.78e-10 Putamen volume; CESC cis rs9951602 0.607 rs3017651 chr18:76668622 T/C cg00806245 chr18:76673096 NA -0.56 -8.1 -0.45 1.98e-14 Obesity-related traits; CESC cis rs6088580 0.634 rs1890000 chr20:32968312 G/T cg24642439 chr20:33292090 TP53INP2 -0.53 -6.99 -0.39 2.23e-11 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16620766 chr12:122268197 SETD1B -0.55 -6.19 -0.36 2.28e-9 Gut microbiome composition (summer); CESC cis rs6736093 0.966 rs6743523 chr2:112693875 G/A cg12686935 chr2:112915763 FBLN7 -0.44 -5.72 -0.33 2.86e-8 Coronary artery disease; CESC cis rs72781680 0.611 rs7596060 chr2:24334361 A/G cg08917208 chr2:24149416 ATAD2B -0.55 -5.41 -0.32 1.42e-7 Lymphocyte counts; CESC cis rs7385804 0.727 rs221790 chr7:100278282 G/C cg16850897 chr7:100343110 ZAN 0.52 7.19 0.4 6.68e-12 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg23978390 chr7:1156363 C7orf50 0.46 6.17 0.35 2.49e-9 Longevity;Endometriosis; CESC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg18337363 chr3:52569053 NT5DC2 -0.3 -5.34 -0.31 2.03e-7 Bipolar disorder; CESC cis rs965513 1.000 rs10759927 chr9:100542176 A/G cg13688889 chr9:100608707 NA -0.61 -8.6 -0.47 7.29e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs965469 1.000 rs6051831 chr20:3373712 G/T cg25506879 chr20:3388711 C20orf194 0.54 5.68 0.33 3.62e-8 IFN-related cytopenia; CESC cis rs559928 0.606 rs12419038 chr11:63912736 A/G cg18225595 chr11:63971243 STIP1 0.65 6.39 0.37 7.54e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg12311346 chr5:56204834 C5orf35 -0.72 -8.75 -0.47 2.48e-16 Initial pursuit acceleration; CESC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg02034447 chr16:89574710 SPG7 0.51 6.44 0.37 5.73e-10 Multiple myeloma (IgH translocation); CESC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs4481887 0.927 rs4341391 chr1:248475720 A/G cg00666640 chr1:248458726 OR2T12 0.34 5.48 0.32 9.82e-8 Common traits (Other); CESC cis rs854765 0.693 rs12936037 chr17:17777245 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.46 -5.96 -0.34 8.19e-9 Total body bone mineral density; CESC cis rs9430161 0.644 rs34365965 chr1:11034442 G/A cg27631724 chr1:11040367 C1orf127 0.38 6.14 0.35 2.99e-9 Ewing sarcoma; CESC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 10.75 0.55 1.29e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg04025307 chr7:1156635 C7orf50 0.58 10.54 0.54 6.57e-22 Longevity;Endometriosis; CESC cis rs34779708 0.966 rs2045918 chr10:35418517 T/G cg03585969 chr10:35415529 CREM 0.75 9.82 0.52 1.29e-19 Inflammatory bowel disease;Crohn's disease; CESC trans rs208520 0.526 rs6913344 chr6:66754285 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -18.8 -0.76 1.15e-50 Exhaled nitric oxide output; CESC cis rs1707322 0.717 rs28396194 chr1:46213227 C/T cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4072980 0.524 rs16824514 chr1:38395947 A/T cg04673462 chr1:38461896 NA 0.36 5.21 0.3 3.84e-7 Coronary artery disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13412395 chr9:102583693 NR4A3 0.48 6.83 0.39 5.84e-11 Systemic lupus erythematosus; CESC cis rs938554 0.513 rs10939650 chr4:9998440 C/T cg11266682 chr4:10021025 SLC2A9 0.48 7.42 0.41 1.62e-12 Blood metabolite levels; CESC cis rs36051895 0.659 rs1575285 chr9:5267440 A/G cg02405213 chr9:5042618 JAK2 -0.5 -6.12 -0.35 3.44e-9 Pediatric autoimmune diseases; CESC cis rs10979 1.000 rs1416208 chr6:143889241 T/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs3091242 0.866 rs11249249 chr1:25758134 A/G cg27572855 chr1:25598939 RHD 0.49 8.37 0.46 3.36e-15 Erythrocyte sedimentation rate; CESC cis rs7129220 0.512 rs1867136 chr11:10228843 C/T cg01453529 chr11:10209919 SBF2 -0.45 -5.55 -0.32 6.79e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs6998277 1.000 rs16869658 chr8:103633762 C/T cg10187029 chr8:103597600 NA 0.57 6.51 0.37 3.68e-10 Migraine; CESC cis rs7589728 1.000 rs75181745 chr2:88520408 C/T cg04511125 chr2:88470314 THNSL2 0.58 5.64 0.33 4.33e-8 Plasma clusterin levels; CESC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg24250549 chr1:154909240 PMVK 0.72 10.45 0.54 1.26e-21 Prostate cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24394865 chr11:66206319 MRPL11 -0.44 -6.16 -0.35 2.72e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03511402 chr16:30583225 ZNF688 -0.66 -7.03 -0.4 1.8e-11 Gut microbiome composition (summer); CESC cis rs892961 0.965 rs312856 chr17:75401598 A/G cg05865280 chr17:75406074 SEPT9 0.66 13.5 0.64 5.81e-32 Airflow obstruction; CESC cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg06481639 chr22:41940642 POLR3H 0.59 6.19 0.36 2.27e-9 Vitiligo; CESC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg16325326 chr1:53192061 ZYG11B -0.72 -11.9 -0.59 1.88e-26 Monocyte count; CESC cis rs7523050 0.558 rs35926243 chr1:109407712 T/A cg08274380 chr1:109419600 GPSM2 0.91 5.92 0.34 9.78e-9 Fat distribution (HIV); CESC cis rs7819412 0.668 rs4841507 chr8:11046394 C/G cg14752069 chr8:11977206 FAM66D -0.3 -5.11 -0.3 6.21e-7 Triglycerides; CESC cis rs4290604 1.000 rs4290604 chr2:238070885 A/G cg23555395 chr2:238036564 NA -0.54 -5.33 -0.31 2.08e-7 Asthma; CESC cis rs10080237 0.564 rs2490230 chr6:80812464 G/A cg08355045 chr6:80787529 NA 0.33 5.09 0.3 6.73e-7 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; CESC cis rs2652834 0.861 rs4774472 chr15:63353760 C/A cg05507819 chr15:63340323 TPM1 0.62 6.31 0.36 1.14e-9 HDL cholesterol; CESC cis rs76878669 0.561 rs4930179 chr11:66157432 C/T cg18002602 chr11:66138449 SLC29A2 0.4 6.76 0.38 8.68e-11 Educational attainment (years of education); CESC cis rs28830936 0.966 rs1107858 chr15:41968226 G/A cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.41 -5.7 -0.33 3.24e-8 Diastolic blood pressure; CESC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg12564285 chr5:131593104 PDLIM4 0.38 5.75 0.33 2.45e-8 Breast cancer; CESC cis rs2427308 0.607 rs1741635 chr20:60938197 C/G cg24112000 chr20:60950667 NA 0.52 6.1 0.35 3.82e-9 Colorectal cancer; CESC trans rs9929218 0.906 rs4783565 chr16:68750190 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -10.24 -0.53 6.05e-21 Colorectal cancer; CESC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg26335602 chr6:28129616 ZNF389 0.53 6.75 0.38 9.35e-11 Depression; CESC cis rs1577917 0.958 rs12196175 chr6:86779370 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.14 -0.35 3.04e-9 Response to antipsychotic treatment; CESC cis rs7917772 0.510 rs2001389 chr10:104375258 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.39 5.41 0.32 1.43e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2262909 0.962 rs2017521 chr19:22126138 T/C cg11619707 chr19:22235551 ZNF257 -0.33 -5.52 -0.32 7.97e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs897984 0.770 rs3813020 chr16:30934075 G/A cg02466173 chr16:30829666 NA 0.49 8.46 0.46 1.82e-15 Dementia with Lewy bodies; CESC cis rs854765 0.693 rs35451946 chr17:17764061 C/G cg16928487 chr17:17741425 SREBF1 0.59 10.71 0.55 1.79e-22 Total body bone mineral density; CESC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.6 5.29 0.31 2.61e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.71 0.33 3.04e-8 Melanoma; CESC cis rs9858542 0.953 rs7648841 chr3:49416825 G/A cg07274523 chr3:49395745 GPX1 0.67 8.37 0.46 3.46e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4319547 0.915 rs7966094 chr12:123115771 A/G cg23029597 chr12:123009494 RSRC2 -0.48 -5.35 -0.31 1.94e-7 Body mass index; CESC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.94 -0.34 8.84e-9 Menopause (age at onset); CESC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg12463550 chr7:65579703 CRCP -0.45 -5.72 -0.33 2.86e-8 Aortic root size; CESC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.77 10.14 0.53 1.23e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs643506 0.845 rs2850245 chr11:111760738 G/T cg17089665 chr11:111648010 NA -0.39 -5.64 -0.33 4.26e-8 Breast cancer; CESC cis rs9487051 0.652 rs6568559 chr6:109592751 C/T cg12927641 chr6:109611667 NA -0.37 -5.56 -0.32 6.55e-8 Reticulocyte fraction of red cells; CESC cis rs7202877 0.706 rs247436 chr16:75445971 T/G cg04384234 chr16:75411784 CFDP1 0.51 5.83 0.34 1.6e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs752010 0.695 rs12123834 chr1:42105727 T/C cg06885757 chr1:42089581 HIVEP3 0.48 7.77 0.43 1.73e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs561341 1.000 rs757009 chr17:30243937 A/G cg13647721 chr17:30228624 UTP6 0.71 7.56 0.42 6.5e-13 Hip circumference adjusted for BMI; CESC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.02 11.6 0.58 1.95e-25 Gut microbiome composition (summer); CESC cis rs1775715 0.870 rs1419168 chr10:32257332 A/C cg18675610 chr10:32216311 ARHGAP12 0.35 5.54 0.32 7.38e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs1003719 0.715 rs8126941 chr21:38551542 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.51 -6.72 -0.38 1.14e-10 Eye color traits; CESC cis rs11098499 0.863 rs1155576 chr4:120450159 A/C cg24375607 chr4:120327624 NA 0.42 5.04 0.3 8.63e-7 Corneal astigmatism; CESC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg21963583 chr11:68658836 MRPL21 0.4 5.52 0.32 8.06e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18364576 chr14:53417060 FERMT2 -0.51 -6.16 -0.35 2.68e-9 Gut microbiome composition (summer); CESC cis rs3747547 0.792 rs72726052 chr9:38056290 C/T cg13774184 chr9:37916125 SHB -0.71 -5.6 -0.33 5.44e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs2486288 0.656 rs11639349 chr15:45568260 C/T cg21132104 chr15:45694354 SPATA5L1 -0.62 -7.26 -0.41 4.26e-12 Glomerular filtration rate; CESC cis rs826838 1.000 rs1095575 chr12:39110284 C/G cg13010199 chr12:38710504 ALG10B -0.41 -5.76 -0.33 2.35e-8 Heart rate; CESC cis rs6570726 0.902 rs9390326 chr6:145791222 A/G cg23711669 chr6:146136114 FBXO30 -0.72 -10.54 -0.54 6.43e-22 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07586489 chr16:3013227 KREMEN2 0.56 6.35 0.36 9.52e-10 Gut microbiome composition (summer); CESC cis rs8180040 0.627 rs6442059 chr3:47187075 C/G cg27129171 chr3:47204927 SETD2 0.67 9.81 0.52 1.36e-19 Colorectal cancer; CESC cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg06108461 chr20:60628389 TAF4 -0.9 -13.85 -0.65 3.57e-33 Body mass index; CESC cis rs9911578 1.000 rs2567911 chr17:56734977 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg02551604 chr5:131831745 NA 0.4 5.62 0.33 4.9e-8 Asthma (sex interaction); CESC trans rs1908814 0.516 rs7833079 chr8:11792129 A/G cg15556689 chr8:8085844 FLJ10661 0.52 6.39 0.37 7.33e-10 Neuroticism; CESC cis rs7267979 1.000 rs6050547 chr20:25326012 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.21 -0.75 1.29e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs9303401 0.659 rs34275691 chr17:56736640 A/T cg10487724 chr17:56770010 TEX14;RAD51C 1.04 13.0 0.62 3.27e-30 Cognitive test performance; CESC cis rs9611565 0.694 rs5758411 chr22:42079734 G/A cg17376030 chr22:41985996 PMM1 -0.45 -5.21 -0.3 3.81e-7 Vitiligo; CESC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg08859206 chr1:53392774 SCP2 -0.68 -9.49 -0.5 1.38e-18 Monocyte count; CESC trans rs9467711 0.606 rs9393706 chr6:26361500 G/A cg06606381 chr12:133084897 FBRSL1 -0.77 -7.01 -0.4 1.94e-11 Autism spectrum disorder or schizophrenia; CESC cis rs870825 0.655 rs1527870 chr4:185616631 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs17253792 0.822 rs10139905 chr14:56170031 T/C cg01858014 chr14:56050164 KTN1 -0.62 -5.67 -0.33 3.78e-8 Putamen volume; CESC cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg22875332 chr1:76189707 ACADM 0.59 5.76 0.33 2.34e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs662064 0.852 rs1411402 chr1:10579545 G/T cg20482658 chr1:10539492 PEX14 0.37 7.64 0.42 4e-13 Asthma; CESC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg08736216 chr1:53307985 ZYG11A -0.44 -7.61 -0.42 4.82e-13 Monocyte count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05989625 chr8:145661381 NFKBIL2 -0.43 -6.62 -0.38 2.02e-10 Gut microbiota (bacterial taxa); CESC cis rs796364 0.951 rs281793 chr2:200847990 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.84 8.14 0.45 1.53e-14 Schizophrenia; CESC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg11941060 chr3:133502564 NA -0.49 -6.7 -0.38 1.23e-10 Iron status biomarkers; CESC cis rs8072100 0.905 rs8077106 chr17:45653291 T/G cg08085267 chr17:45401833 C17orf57 0.44 5.9 0.34 1.12e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg12879727 chr14:75061268 LTBP2 0.41 6.01 0.35 6.18e-9 Thyroid stimulating hormone; CESC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg00310523 chr12:86230176 RASSF9 0.36 5.63 0.33 4.6e-8 Major depressive disorder; CESC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.28 0.31 2.75e-7 Menopause (age at onset); CESC cis rs4423214 0.879 rs1790330 chr11:71147825 C/T cg05163923 chr11:71159392 DHCR7 -0.61 -7.24 -0.41 4.76e-12 Vitamin D levels; CESC cis rs634534 0.561 rs655744 chr11:65776585 G/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.44 -6.58 -0.37 2.53e-10 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs11871801 0.517 rs646123 chr17:40720632 G/A cg21433558 chr17:40837037 CNTNAP1 0.49 5.96 0.34 8.14e-9 Crohn's disease; CESC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.47 0.46 1.74e-15 Bipolar disorder; CESC cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg18180107 chr4:99064573 C4orf37 0.4 5.16 0.3 4.84e-7 Colonoscopy-negative controls vs population controls; CESC cis rs8028182 0.636 rs4886703 chr15:75730366 C/T cg20655648 chr15:75932815 IMP3 0.49 6.2 0.36 2.13e-9 Sudden cardiac arrest; CESC cis rs7662987 0.517 rs1311617 chr4:100012425 T/G cg13256891 chr4:100009986 ADH5 0.74 7.97 0.44 4.75e-14 Smoking initiation; CESC cis rs2637266 0.783 rs846583 chr10:78495658 T/A cg18941641 chr10:78392320 NA 0.4 7.69 0.43 2.87e-13 Pulmonary function; CESC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg05368731 chr17:41323189 NBR1 0.8 11.32 0.57 1.66e-24 Menopause (age at onset); CESC cis rs782590 0.902 rs782601 chr2:55848244 T/C cg18811423 chr2:55921094 PNPT1 0.79 12.15 0.6 2.79e-27 Metabolic syndrome; CESC cis rs9486719 1.000 rs2472897 chr6:96870569 G/T cg18709589 chr6:96969512 KIAA0776 0.54 5.91 0.34 1.07e-8 Migraine;Coronary artery disease; CESC cis rs2070433 0.752 rs60290737 chr21:47837630 C/A cg12379764 chr21:47803548 PCNT 0.67 7.31 0.41 3.08e-12 Lymphocyte counts; CESC cis rs933688 0.532 rs11740007 chr5:90545498 C/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.46 -5.33 -0.31 2.12e-7 Smoking behavior; CESC cis rs662064 0.962 rs1188525 chr1:10550877 A/G cg20482658 chr1:10539492 PEX14 -0.39 -8.0 -0.44 3.93e-14 Asthma; CESC cis rs7605827 0.930 rs6728145 chr2:15573489 C/G cg19274914 chr2:15703543 NA 0.36 6.45 0.37 5.41e-10 Educational attainment (years of education); CESC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg25036284 chr2:26402008 FAM59B 0.68 7.34 0.41 2.54e-12 Gut microbiome composition (summer); CESC cis rs7917772 0.636 rs2249845 chr10:104512095 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.45 -5.3 -0.31 2.45e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9399135 0.967 rs34546690 chr6:135369709 T/C cg24558204 chr6:135376177 HBS1L 0.5 6.8 0.39 6.92e-11 Red blood cell count; CESC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg18446336 chr7:2847575 GNA12 -0.35 -5.56 -0.32 6.7e-8 Height; CESC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 5.05 0.3 8.05e-7 Bipolar disorder; CESC cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg05340658 chr4:99064831 C4orf37 0.79 12.28 0.6 9.45e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04089111 chr2:74942655 NA 0.66 8.04 0.44 3.07e-14 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs763121 0.853 rs4821811 chr22:39075145 C/T cg06022373 chr22:39101656 GTPBP1 0.9 14.07 0.65 5.86e-34 Menopause (age at onset); CESC cis rs2247341 0.965 rs2236787 chr4:1718883 A/T cg07465881 chr4:1713556 SLBP -0.51 -6.34 -0.36 9.71e-10 Hip circumference adjusted for BMI;Height; CESC cis rs72772090 0.539 rs11750934 chr5:96118487 A/C cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.21 -0.3 3.74e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs10927875 0.631 rs28579893 chr1:16347534 A/G cg22431228 chr1:16359049 CLCNKA -0.51 -8.41 -0.46 2.57e-15 Dilated cardiomyopathy; CESC cis rs7851660 0.874 rs1955145 chr9:100634751 A/C cg13688889 chr9:100608707 NA 0.62 8.73 0.47 2.94e-16 Strep throat; CESC cis rs77956314 0.515 rs4767490 chr12:117435016 A/G cg02017074 chr12:117425053 FBXW8 0.79 8.45 0.46 1.96e-15 Subcortical brain region volumes;Hippocampal volume; CESC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg22920501 chr2:26401640 FAM59B -0.65 -7.79 -0.43 1.51e-13 Gut microbiome composition (summer); CESC cis rs35740288 0.545 rs12916187 chr15:86326124 A/C cg20737812 chr15:86336631 KLHL25 -0.47 -5.44 -0.32 1.19e-7 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.79e-7 Gut microbiome composition (summer); CESC trans rs9951602 0.512 rs4799245 chr18:76653397 T/C cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg05347473 chr6:146136440 FBXO30 0.58 7.34 0.41 2.64e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs16957304 1.000 rs13334364 chr16:67332365 T/C cg26727032 chr16:67993705 SLC12A4 -0.52 -5.12 -0.3 5.79e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CESC cis rs8058578 0.832 rs7500719 chr16:30840877 C/T cg02466173 chr16:30829666 NA -0.48 -7.66 -0.43 3.54e-13 Multiple myeloma; CESC cis rs12971120 0.947 rs8083001 chr18:72165058 A/G cg26446133 chr18:72167187 CNDP2 -0.68 -10.0 -0.52 3.47e-20 Refractive error; CESC cis rs2404602 0.619 rs7342603 chr15:76982625 C/T cg26408565 chr15:76604113 ETFA -0.39 -5.56 -0.32 6.68e-8 Blood metabolite levels; CESC cis rs72634258 0.945 rs12753070 chr1:8114319 C/G cg00042356 chr1:8021962 PARK7 0.8 7.14 0.4 9.2e-12 Inflammatory bowel disease; CESC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg14393609 chr7:65229607 NA 0.48 6.38 0.37 7.71e-10 Aortic root size; CESC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg06873352 chr17:61820015 STRADA 0.48 7.0 0.4 2.08e-11 Height; CESC cis rs7589342 0.839 rs6747023 chr2:106431856 A/G cg16077055 chr2:106428750 NCK2 0.52 7.44 0.42 1.42e-12 Addiction; CESC cis rs2760061 0.626 rs596675 chr1:228117892 G/A cg02753203 chr1:228287806 NA -0.5 -7.15 -0.4 8.25e-12 Diastolic blood pressure; CESC trans rs17508449 0.865 rs76308249 chr1:114147681 A/G cg23028848 chr11:57092561 TNKS1BP1 -0.77 -6.14 -0.35 2.98e-9 Leprosy; CESC cis rs116095464 0.558 rs7714335 chr5:263513 T/C cg10591111 chr5:226296 SDHA -0.54 -6.11 -0.35 3.55e-9 Breast cancer; CESC cis rs11229555 0.957 rs10896796 chr11:58394256 A/G cg15696309 chr11:58395628 NA -0.43 -5.63 -0.33 4.63e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs7824557 0.767 rs6985460 chr8:11171087 A/C cg21775007 chr8:11205619 TDH 0.46 6.67 0.38 1.49e-10 Retinal vascular caliber; CESC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg27478167 chr7:817139 HEATR2 -0.53 -5.67 -0.33 3.82e-8 Cerebrospinal P-tau181p levels; CESC cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg24308560 chr3:49941425 MST1R 0.61 9.04 0.49 3.45e-17 Intelligence (multi-trait analysis); CESC cis rs4077515 0.577 rs10870165 chr9:139316601 C/T cg14169450 chr9:139327907 INPP5E 0.47 6.9 0.39 3.72e-11 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs7539409 0.651 rs910182 chr1:84297117 A/G cg10977910 chr1:84465055 TTLL7 0.76 7.29 0.41 3.56e-12 Alzheimer's disease; CESC cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg19077165 chr18:44547161 KATNAL2 -0.62 -9.31 -0.5 5.06e-18 Personality dimensions; CESC cis rs8018808 0.935 rs8005759 chr14:77880493 C/T cg20045696 chr14:77926864 AHSA1 0.42 5.84 0.34 1.49e-8 Myeloid white cell count; CESC cis rs6963495 0.818 rs73190151 chr7:105152887 C/T cg13798780 chr7:105162888 PUS7 0.78 8.0 0.44 4.02e-14 Bipolar disorder (body mass index interaction); CESC cis rs7216064 0.684 rs7406031 chr17:66021753 C/T cg12091567 chr17:66097778 LOC651250 0.85 11.08 0.56 1.08e-23 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7086627 0.515 rs11202957 chr10:82209592 A/G cg00277334 chr10:82204260 NA -0.91 -15.92 -0.7 1.67e-40 Post bronchodilator FEV1; CESC cis rs6088590 0.710 rs6059992 chr20:33282275 T/C cg06115741 chr20:33292138 TP53INP2 0.45 5.57 0.32 6.09e-8 Coronary artery disease; CESC trans rs3942852 0.568 rs10769312 chr11:48094769 C/T cg03929089 chr4:120376271 NA 0.63 7.64 0.42 4.01e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg16405210 chr4:1374714 KIAA1530 -0.95 -12.85 -0.62 1.03e-29 Longevity; CESC cis rs72945132 0.882 rs7945389 chr11:70158876 C/A cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs4851551 0.619 rs34722443 chr2:102840319 T/G cg09363443 chr2:102758946 NA 0.65 5.28 0.31 2.74e-7 Blood protein levels; CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg16145915 chr7:1198662 ZFAND2A -0.7 -11.11 -0.56 8.87e-24 Longevity;Endometriosis; CESC cis rs6500602 0.702 rs3761680 chr16:4524060 C/A cg08645402 chr16:4508243 NA 0.57 9.37 0.5 3.26e-18 Schizophrenia; CESC cis rs4253772 0.550 rs11703564 chr22:46722194 G/A cg10541313 chr22:46663664 TTC38 0.68 5.11 0.3 6.11e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg13206674 chr6:150067644 NUP43 0.46 6.59 0.38 2.43e-10 Lung cancer; CESC cis rs7932354 0.655 rs6485690 chr11:46798631 A/G cg25783544 chr11:47291846 MADD -0.4 -5.14 -0.3 5.22e-7 Bone mineral density (hip);Bone mineral density; CESC cis rs6582630 0.538 rs7971292 chr12:38498151 A/G cg26384229 chr12:38710491 ALG10B -0.44 -5.94 -0.34 8.88e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg20476274 chr7:133979776 SLC35B4 0.68 10.07 0.53 2.04e-20 Mean platelet volume; CESC cis rs9486719 1.000 rs12191653 chr6:96903898 T/C cg18709589 chr6:96969512 KIAA0776 -0.54 -5.97 -0.34 7.42e-9 Migraine;Coronary artery disease; CESC cis rs76878669 0.515 rs947978 chr11:66108660 C/T cg18002602 chr11:66138449 SLC29A2 0.41 6.75 0.38 9.45e-11 Educational attainment (years of education); CESC cis rs2439831 0.850 rs7174208 chr15:44052682 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.7 8.05 0.44 2.82e-14 Lung cancer in ever smokers; CESC cis rs832540 0.898 rs252890 chr5:56226410 T/C cg12311346 chr5:56204834 C5orf35 -0.42 -5.29 -0.31 2.51e-7 Coronary artery disease; CESC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg19592336 chr6:28129416 ZNF389 0.6 7.88 0.44 8.73e-14 Depression; CESC trans rs2900976 0.739 rs13016025 chr2:72003083 A/G cg01646268 chr11:14367071 RRAS2 -0.47 -6.37 -0.36 8.52e-10 Protein quantitative trait loci; CESC trans rs55863869 0.748 rs77841333 chr2:179624788 A/T cg24136754 chr22:37403978 C22orf33 0.44 6.07 0.35 4.34e-9 QT interval; CESC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg21248554 chr2:27665150 KRTCAP3 -0.34 -6.98 -0.39 2.43e-11 Menopause (age at onset); CESC cis rs854765 0.583 rs62064156 chr17:17822480 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.52 7.22 0.41 5.4e-12 Total body bone mineral density; CESC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg11301795 chr4:187892539 NA -0.8 -14.23 -0.66 1.54e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs9611565 0.559 rs1006407 chr22:41972032 T/C cg06634786 chr22:41940651 POLR3H -0.69 -6.64 -0.38 1.79e-10 Vitiligo; CESC cis rs35079168 0.923 rs10858276 chr9:137287913 C/T cg13941235 chr9:137270186 RXRA -0.31 -5.65 -0.33 4.08e-8 Intelligence; CESC cis rs7666738 0.830 rs7680909 chr4:98934604 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg00684032 chr4:1343700 KIAA1530 0.37 5.54 0.32 7.28e-8 Obesity-related traits; CESC cis rs8067354 0.681 rs9907923 chr17:57824927 C/T cg02344993 chr17:57696989 CLTC 0.68 8.08 0.44 2.34e-14 Hemoglobin concentration; CESC cis rs7937682 1.000 rs10789843 chr11:111576158 C/T cg09085632 chr11:111637200 PPP2R1B 1.05 14.75 0.67 2.39e-36 Primary sclerosing cholangitis; CESC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg18404041 chr3:52824283 ITIH1 -0.4 -6.73 -0.38 1.04e-10 Bipolar disorder; CESC cis rs9400271 0.632 rs9372205 chr6:109588401 A/T cg01475377 chr6:109611718 NA -0.46 -7.18 -0.4 7.24e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs36051895 0.659 rs12351277 chr9:5061405 A/C cg02405213 chr9:5042618 JAK2 -0.51 -6.15 -0.35 2.87e-9 Pediatric autoimmune diseases; CESC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg07701084 chr6:150067640 NUP43 0.41 5.74 0.33 2.65e-8 Lung cancer; CESC cis rs1801251 1.000 rs1446311 chr2:233705071 G/A cg08000102 chr2:233561755 GIGYF2 -0.7 -10.11 -0.53 1.51e-20 Coronary artery disease; CESC cis rs60154123 0.772 rs628908 chr1:210428002 C/T cg22029157 chr1:209979665 IRF6 0.45 5.24 0.31 3.29e-7 Coronary artery disease; CESC cis rs9291683 0.588 rs6857693 chr4:10018435 G/A cg02734326 chr4:10020555 SLC2A9 0.52 7.43 0.42 1.51e-12 Bone mineral density; CESC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg08499158 chr17:42289980 UBTF -0.49 -6.15 -0.35 2.83e-9 Total body bone mineral density; CESC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg07343612 chr16:622815 PIGQ -0.52 -7.53 -0.42 8.09e-13 Height; CESC cis rs17401966 0.838 rs34565762 chr1:10300119 T/C cg15208524 chr1:10270712 KIF1B 0.4 5.2 0.3 4.06e-7 Hepatocellular carcinoma; CESC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg19592336 chr6:28129416 ZNF389 0.59 7.88 0.44 8.48e-14 Depression; CESC cis rs4253772 0.530 rs55653327 chr22:46682976 C/T cg18190219 chr22:46762943 CELSR1 -0.59 -5.52 -0.32 8.08e-8 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16601444 chr19:47214184 PRKD2 -0.54 -6.18 -0.35 2.35e-9 Gut microbiome composition (summer); CESC cis rs6502050 0.814 rs9894554 chr17:80073423 C/G cg11859384 chr17:80120422 CCDC57 0.39 5.38 0.31 1.64e-7 Life satisfaction; CESC cis rs7656342 0.653 rs1401439 chr4:9832622 G/C cg11266682 chr4:10021025 SLC2A9 0.33 5.26 0.31 3e-7 Gut microbiota (bacterial taxa); CESC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg04414720 chr1:150670196 GOLPH3L 0.44 5.84 0.34 1.49e-8 Melanoma; CESC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg22920501 chr2:26401640 FAM59B -0.93 -10.89 -0.56 4.54e-23 Gut microbiome composition (summer); CESC cis rs644799 1.000 rs514170 chr11:95556696 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.27 0.66 1.19e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs12586317 0.513 rs17102962 chr14:35478782 A/T cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC cis rs2304069 0.954 rs9324640 chr5:149413186 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.86 -11.11 -0.56 8.8e-24 HIV-1 control; CESC cis rs9291683 0.561 rs3733584 chr4:10036506 T/C cg00071950 chr4:10020882 SLC2A9 0.87 15.5 0.69 5.06e-39 Bone mineral density; CESC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg19318889 chr4:1322082 MAEA -0.56 -7.09 -0.4 1.22e-11 Longevity; CESC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg09365446 chr1:150670422 GOLPH3L 0.38 5.27 0.31 2.88e-7 Tonsillectomy; CESC cis rs96067 0.805 rs7522400 chr1:36613380 A/G cg24686825 chr1:36642396 MAP7D1 -0.5 -5.6 -0.33 5.35e-8 Corneal structure; CESC cis rs12586317 0.586 rs74243590 chr14:35513246 G/A cg05294307 chr14:35346193 BAZ1A -0.57 -5.82 -0.34 1.71e-8 Psoriasis; CESC cis rs7605827 0.866 rs9710962 chr2:15533884 C/A cg19274914 chr2:15703543 NA 0.36 6.59 0.38 2.3e-10 Educational attainment (years of education); CESC cis rs2797685 1.000 rs1689904 chr1:7890801 C/T cg04725166 chr1:7887271 PER3 -0.47 -6.42 -0.37 6.44e-10 Crohn's disease; CESC cis rs34779708 0.931 rs67261877 chr10:35386340 T/A cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.49 -0.32 9.34e-8 Parkinson's disease; CESC cis rs4964805 0.657 rs4964813 chr12:104189554 T/C cg02344784 chr12:104178138 NT5DC3 0.45 6.38 0.36 7.88e-10 Attention deficit hyperactivity disorder; CESC cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg03060546 chr3:49711283 APEH 0.52 6.45 0.37 5.33e-10 Parkinson's disease; CESC cis rs2204008 0.570 rs12318341 chr12:38251087 T/C cg26384229 chr12:38710491 ALG10B -0.47 -6.09 -0.35 4.03e-9 Bladder cancer; CESC cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.31 0.31 2.28e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.87 14.04 0.65 7.75e-34 Hip circumference adjusted for BMI; CESC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg24562669 chr7:97807699 LMTK2 0.51 7.64 0.42 4.09e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs7568498 0.564 rs9287807 chr2:161915361 T/C cg22496339 chr2:162101262 NA -0.52 -5.51 -0.32 8.44e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs7937682 0.883 rs1784776 chr11:111472392 C/T cg09085632 chr11:111637200 PPP2R1B -0.94 -13.87 -0.65 2.84e-33 Primary sclerosing cholangitis; CESC cis rs11785400 0.762 rs7017931 chr8:143726728 A/G cg10596483 chr8:143751796 JRK 0.42 5.36 0.31 1.77e-7 Schizophrenia; CESC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg14159672 chr1:205819179 PM20D1 0.46 6.6 0.38 2.27e-10 Menarche (age at onset); CESC cis rs4237845 0.735 rs11172375 chr12:58291574 G/C cg02175503 chr12:58329896 NA 0.64 7.9 0.44 7.24e-14 Intelligence (multi-trait analysis); CESC cis rs9894429 1.000 rs11652797 chr17:79574124 A/G cg21984481 chr17:79567631 NPLOC4 -0.49 -8.04 -0.44 2.93e-14 Eye color traits; CESC cis rs193541 0.632 rs168913 chr5:122225793 G/A cg19412675 chr5:122181750 SNX24 0.46 5.4 0.31 1.5e-7 Glucose homeostasis traits; CESC cis rs10870270 0.956 rs67378218 chr10:133752420 A/C cg26149184 chr10:133730230 NA 0.37 5.07 0.3 7.46e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs61996546 0.622 rs1426219 chr15:26855799 C/T cg15066197 chr15:26874202 GABRB3 -0.35 -5.19 -0.3 4.1e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs7149337 1.000 rs8006432 chr14:51731306 A/T cg23942311 chr14:51606299 NA 0.43 7.22 0.41 5.35e-12 Cancer; CESC cis rs7216064 1.000 rs7221651 chr17:65832390 A/G cg12091567 chr17:66097778 LOC651250 0.79 8.86 0.48 1.18e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs478304 0.934 rs517115 chr11:65526988 C/T cg08755490 chr11:65554678 OVOL1 0.49 6.5 0.37 3.95e-10 Acne (severe); CESC cis rs623323 1.000 rs623323 chr17:700020 A/G cg02666820 chr17:700054 NA 0.95 11.06 0.56 1.3e-23 Type 2 diabetes; CESC cis rs2070677 0.736 rs7895560 chr10:135431038 G/A cg20169779 chr10:135381914 SYCE1 -0.79 -8.98 -0.48 5.18e-17 Gout; CESC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg11764359 chr7:65958608 NA -0.79 -9.47 -0.5 1.62e-18 Aortic root size; CESC cis rs6942756 0.715 rs6467242 chr7:129001173 T/A cg02491457 chr7:128862824 NA -0.6 -8.34 -0.46 4.23e-15 White matter hyperintensity burden; CESC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg11941060 chr3:133502564 NA 0.49 6.78 0.38 7.87e-11 Iron status biomarkers; CESC cis rs8062405 0.964 rs7187333 chr16:28865916 G/A cg08761264 chr16:28874980 SH2B1 -0.45 -5.49 -0.32 9.61e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs738322 0.839 rs2413505 chr22:38592967 G/A cg25457927 chr22:38595422 NA 0.35 6.59 0.38 2.41e-10 Cutaneous nevi; CESC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.34 0.41 2.56e-12 Tonsillectomy; CESC cis rs7208859 0.623 rs9899268 chr17:29150255 T/C cg19761014 chr17:28927070 LRRC37B2 0.79 6.45 0.37 5.22e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2652834 0.808 rs11071723 chr15:63355275 A/T cg05507819 chr15:63340323 TPM1 0.62 6.08 0.35 4.22e-9 HDL cholesterol; CESC cis rs6582630 0.555 rs10880520 chr12:38464111 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.82 0.55 7.82e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs10791097 0.967 rs10791099 chr11:130718813 G/C cg14779329 chr11:130786720 SNX19 0.4 6.25 0.36 1.67e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg24829409 chr8:58192753 C8orf71 -0.67 -7.97 -0.44 4.6e-14 Developmental language disorder (linguistic errors); CESC cis rs7560272 0.512 rs2421677 chr2:73965917 G/T cg20560298 chr2:73613845 ALMS1 0.4 5.42 0.32 1.35e-7 Schizophrenia; CESC cis rs9296736 1.000 rs7450517 chr6:53902843 G/A cg04374786 chr6:53939321 C6orf142 0.36 5.68 0.33 3.59e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg00750074 chr16:89608354 SPG7 -0.45 -6.49 -0.37 4.22e-10 Multiple myeloma (IgH translocation); CESC cis rs7772486 0.790 rs2247206 chr6:146216184 C/T cg23711669 chr6:146136114 FBXO30 0.82 11.64 0.58 1.47e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg08859206 chr1:53392774 SCP2 -0.57 -7.53 -0.42 8.07e-13 Monocyte count; CESC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg09491104 chr22:46646882 C22orf40 -0.52 -6.43 -0.37 5.82e-10 LDL cholesterol;Cholesterol, total; CESC cis rs4834770 1.000 rs878375 chr4:120237574 T/C cg09307838 chr4:120376055 NA 0.44 5.31 0.31 2.29e-7 Blood protein levels; CESC cis rs593982 0.925 rs3953806 chr11:65505153 C/T cg08755490 chr11:65554678 OVOL1 -1.26 -10.56 -0.54 5.65e-22 Atopic dermatitis; CESC cis rs2274273 0.774 rs17128440 chr14:55861912 C/T cg04306507 chr14:55594613 LGALS3 0.3 5.94 0.34 9.13e-9 Protein biomarker; CESC cis rs1983170 0.736 rs13447495 chr1:91974965 A/G cg02896835 chr1:92012615 NA 0.56 6.03 0.35 5.56e-9 Eosinophil percentage of white cells; CESC cis rs6964587 0.740 rs2020360 chr7:91439506 G/C cg17063962 chr7:91808500 NA 0.49 6.31 0.36 1.15e-9 Breast cancer; CESC trans rs4332037 0.539 rs55790766 chr7:2021248 C/T cg11693508 chr17:37793320 STARD3 0.67 6.73 0.38 1.07e-10 Bipolar disorder; CESC cis rs10751667 0.666 rs7395823 chr11:942701 T/C cg06064525 chr11:970664 AP2A2 -0.5 -10.04 -0.52 2.7e-20 Alzheimer's disease (late onset); CESC cis rs2479106 0.591 rs1475526 chr9:126396659 G/A cg16191174 chr9:126692580 DENND1A 0.38 5.33 0.31 2.09e-7 Polycystic ovary syndrome; CESC cis rs826838 0.967 rs10875979 chr12:39095149 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.56 0.37 2.74e-10 Heart rate; CESC cis rs7666738 0.688 rs4632667 chr4:98748299 A/G cg03676636 chr4:99064102 C4orf37 0.43 5.17 0.3 4.66e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7656342 0.622 rs2102872 chr4:9831358 T/C cg11266682 chr4:10021025 SLC2A9 0.32 5.15 0.3 5.11e-7 Gut microbiota (bacterial taxa); CESC cis rs7674212 0.570 rs6810571 chr4:104086787 G/T cg16532752 chr4:104119610 CENPE -0.44 -5.96 -0.34 8.1e-9 Type 2 diabetes; CESC cis rs765787 0.530 rs28524974 chr15:45543528 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -6.93 -0.39 3.22e-11 Uric acid levels; CESC cis rs7640424 0.649 rs62262371 chr3:107896108 C/T cg09227934 chr3:107805635 CD47 -0.45 -5.82 -0.34 1.66e-8 Body mass index; CESC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg15921436 chr17:44337874 NA -0.48 -6.25 -0.36 1.63e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04902049 chr1:36622448 MAP7D1 0.51 6.95 0.39 2.78e-11 Systemic lupus erythematosus; CESC cis rs66561647 0.634 rs7821856 chr8:128939499 A/G cg05480350 chr8:128972681 MIR1205;PVT1 0.39 5.2 0.3 3.95e-7 Hemoglobin concentration; CESC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg06494592 chr3:125709126 NA -0.48 -5.09 -0.3 6.89e-7 Blood pressure (smoking interaction); CESC cis rs483180 0.512 rs598685 chr1:120215269 G/A cg19096424 chr1:120255104 PHGDH 0.42 5.13 0.3 5.49e-7 Macular telangiectasia type 2; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05898629 chr16:3812688 CREBBP 0.43 6.14 0.35 3.01e-9 Fibrinogen levels; CESC cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.04 -0.4 1.63e-11 Developmental language disorder (linguistic errors); CESC cis rs929596 0.755 rs3771341 chr2:234673239 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.71 -9.26 -0.49 7.28e-18 Total bilirubin levels in HIV-1 infection; CESC cis rs6032067 0.929 rs17424356 chr20:43804190 A/G cg11264863 chr20:43835661 SEMG1 0.5 5.39 0.31 1.56e-7 Blood protein levels; CESC cis rs9739070 1 rs9739070 chr12:123771032 A/G cg19016782 chr12:123741754 C12orf65 -0.44 -5.93 -0.34 9.36e-9 Allergy; CESC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg20151795 chr6:28129481 ZNF389 0.36 5.23 0.31 3.44e-7 Cardiac Troponin-T levels; CESC cis rs300703 0.719 rs437853 chr2:196973 C/T cg21211680 chr2:198530 NA -1.03 -11.83 -0.59 3.23e-26 Blood protein levels; CESC cis rs8017423 0.647 rs11623736 chr14:90746471 G/T cg14092571 chr14:90743983 NA 0.55 8.18 0.45 1.18e-14 Mortality in heart failure; CESC trans rs11098499 0.708 rs11732686 chr4:120252330 C/A cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg18404041 chr3:52824283 ITIH1 -0.44 -7.28 -0.41 3.85e-12 Bipolar disorder; CESC cis rs11792861 0.962 rs11789624 chr9:111796231 T/C cg14384093 chr9:111878565 C9orf5 -0.4 -5.03 -0.3 8.95e-7 Menarche (age at onset); CESC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.03e-7 Life satisfaction; CESC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg16049864 chr8:95962084 TP53INP1 -0.64 -11.23 -0.57 3.53e-24 Type 2 diabetes; CESC trans rs4650994 0.525 rs4076563 chr1:178516901 C/T cg05059571 chr16:84539110 KIAA1609 -0.4 -6.22 -0.36 1.93e-9 HDL cholesterol levels;HDL cholesterol; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09656405 chr15:69745057 RPLP1 0.54 7.17 0.4 7.63e-12 Systemic lupus erythematosus; CESC cis rs4523957 0.553 rs2131702 chr17:2025458 T/C cg16513277 chr17:2031491 SMG6 -0.77 -11.34 -0.57 1.43e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs6076065 0.748 rs2424542 chr20:23386800 C/T cg11657817 chr20:23433608 CST11 0.41 6.24 0.36 1.69e-9 Facial morphology (factor 15, philtrum width); CESC cis rs10129255 0.500 rs10142931 chr14:107190525 A/C cg23076370 chr14:107095027 NA -0.71 -10.97 -0.56 2.43e-23 Kawasaki disease; CESC cis rs7828089 0.935 rs2293144 chr8:22262418 A/G cg12081754 chr8:22256438 SLC39A14 0.45 6.04 0.35 5.24e-9 Verbal declarative memory; CESC cis rs3768617 0.966 rs10797850 chr1:183094802 G/A ch.1.3577855R chr1:183094577 LAMC1 0.65 9.03 0.49 3.63e-17 Fuchs's corneal dystrophy; CESC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg05313129 chr8:58192883 C8orf71 -0.56 -6.45 -0.37 5.31e-10 Developmental language disorder (linguistic errors); CESC cis rs68170813 0.559 rs75154004 chr7:106903326 C/T cg02696742 chr7:106810147 HBP1 -0.52 -5.09 -0.3 6.84e-7 Coronary artery disease; CESC cis rs798766 1.000 rs798741 chr4:1712413 A/G cg05874882 chr4:1763078 NA -0.58 -8.42 -0.46 2.39e-15 Bladder cancer;Urinary bladder cancer; CESC cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg17366294 chr4:99064904 C4orf37 0.58 8.25 0.45 7.46e-15 Colonoscopy-negative controls vs population controls; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24881159 chr15:31284219 MTMR10 -0.45 -6.26 -0.36 1.51e-9 Gambling; CESC cis rs7809799 1.000 rs6969313 chr7:98754007 G/A cg05967295 chr7:98741636 SMURF1 -0.75 -5.21 -0.3 3.86e-7 Ulcerative colitis; CESC cis rs6831352 0.734 rs3018046 chr4:100030388 C/T cg13256891 chr4:100009986 ADH5 0.69 8.13 0.45 1.61e-14 Alcohol dependence; CESC cis rs9611565 0.559 rs8139993 chr22:41995335 T/C cg03806693 chr22:41940476 POLR3H -0.85 -10.05 -0.53 2.41e-20 Vitiligo; CESC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg11859384 chr17:80120422 CCDC57 -0.4 -5.39 -0.31 1.52e-7 Life satisfaction; CESC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.64 0.51 4.66e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9457247 1.000 rs416131 chr6:167406544 A/C cg23791538 chr6:167370224 RNASET2 0.58 8.18 0.45 1.21e-14 Crohn's disease; CESC trans rs7902708 0.920 rs12416665 chr10:54430631 C/T cg26219051 chr22:43739629 SCUBE1 0.5 6.26 0.36 1.56e-9 Bone properties (heel); CESC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg25072359 chr17:41440525 NA 0.45 5.96 0.34 7.83e-9 Menopause (age at onset); CESC cis rs1256061 0.624 rs944046 chr14:64700299 G/A cg23250157 chr14:64679961 SYNE2 0.52 7.38 0.41 2.1e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs11122272 0.735 rs2808583 chr1:231512587 G/C cg06096015 chr1:231504339 EGLN1 0.43 6.16 0.35 2.62e-9 Hemoglobin concentration; CESC cis rs10751667 0.643 rs11246344 chr11:933783 A/C cg20946044 chr11:1010712 AP2A2 -0.4 -5.43 -0.32 1.26e-7 Alzheimer's disease (late onset); CESC cis rs6466055 0.720 rs2040914 chr7:104972174 A/G cg04380332 chr7:105027541 SRPK2 0.41 5.54 0.32 7.47e-8 Schizophrenia; CESC cis rs1707322 0.685 rs6690926 chr1:46134978 T/C cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.9 9.16 0.49 1.48e-17 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25649200 chr17:79233120 SLC38A10 0.47 6.56 0.37 2.86e-10 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19547976 chr4:1737009 TACC3 -0.55 -6.29 -0.36 1.29e-9 Gut microbiome composition (summer); CESC cis rs11785400 1.000 rs6995314 chr8:143749718 A/G cg10596483 chr8:143751796 JRK -0.43 -5.64 -0.33 4.32e-8 Schizophrenia; CESC cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg18850127 chr7:39170497 POU6F2 0.36 5.12 0.3 5.98e-7 IgG glycosylation; CESC cis rs9522267 0.502 rs9515450 chr13:112234262 T/C cg10483660 chr13:112241077 NA -0.32 -5.69 -0.33 3.32e-8 Hepatitis; CESC cis rs7072216 0.763 rs12763044 chr10:100167451 C/G cg26618903 chr10:100175079 PYROXD2 -0.36 -5.49 -0.32 9.42e-8 Metabolite levels; CESC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg19257562 chr1:2043853 PRKCZ 0.35 5.74 0.33 2.54e-8 Height; CESC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg10691866 chr7:65817282 TPST1 0.31 5.32 0.31 2.25e-7 Aortic root size; CESC cis rs9790314 0.645 rs9879687 chr3:160874938 A/G cg03342759 chr3:160939853 NMD3 -0.41 -5.79 -0.34 1.96e-8 Morning vs. evening chronotype; CESC cis rs950169 1.000 rs12916348 chr15:84765527 C/T cg17507749 chr15:85114479 UBE2QP1 0.61 6.73 0.38 1.05e-10 Schizophrenia; CESC cis rs8014204 0.935 rs10141438 chr14:75354600 A/G cg26191576 chr14:75389716 RPS6KL1 0.35 5.03 0.3 9.15e-7 Caffeine consumption; CESC cis rs7212590 0.655 rs34687426 chr17:57997857 A/G cg20303301 chr17:57937339 TUBD1 -0.52 -5.28 -0.31 2.76e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg14393609 chr7:65229607 NA 0.41 5.77 0.33 2.21e-8 Aortic root size; CESC trans rs8073060 0.505 rs225270 chr17:33968871 A/T cg19694781 chr19:47549865 TMEM160 -0.73 -7.03 -0.4 1.79e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg27170947 chr2:26402098 FAM59B -0.6 -7.25 -0.41 4.7e-12 Gut microbiome composition (summer); CESC cis rs3204270 0.759 rs62075725 chr17:79611510 A/G cg18367735 chr17:79674897 NA 0.62 5.11 0.3 6.13e-7 Dental caries; CESC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.67 -0.33 3.8e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs9831754 0.906 rs7621811 chr3:78388816 G/A cg06138941 chr3:78371609 NA -0.64 -7.66 -0.43 3.46e-13 Calcium levels; CESC cis rs7940866 0.801 rs2113929 chr11:130835974 G/A cg12179176 chr11:130786555 SNX19 0.67 10.29 0.53 4.16e-21 Schizophrenia; CESC cis rs6582630 0.519 rs4002438 chr12:38484880 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.95 0.34 8.55e-9 Drug-induced liver injury (flucloxacillin); CESC trans rs9325144 0.600 rs1825807 chr12:38737007 T/C cg23762105 chr12:34175262 ALG10 -0.48 -6.49 -0.37 4.19e-10 Morning vs. evening chronotype; CESC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg04414720 chr1:150670196 GOLPH3L 0.58 8.2 0.45 1.01e-14 Tonsillectomy; CESC cis rs2836633 0.929 rs8130434 chr21:40036243 C/T cg05519781 chr21:40033154 ERG -0.8 -14.38 -0.66 4.92e-35 Coronary artery disease; CESC cis rs3857067 0.506 rs282450 chr4:95139598 G/C cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.56 -0.58 2.74e-25 QT interval; CESC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg23758822 chr17:41437982 NA 1.02 15.27 0.68 3.45e-38 Menopause (age at onset); CESC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg23281280 chr6:28129359 ZNF389 0.49 6.48 0.37 4.42e-10 Parkinson's disease; CESC cis rs6547741 0.904 rs2384659 chr2:27856793 G/A cg21248554 chr2:27665150 KRTCAP3 0.26 5.34 0.31 2.01e-7 Oral cavity cancer; CESC cis rs2276314 1.000 rs2276314 chr18:33557466 C/T cg19628046 chr18:33552617 C18orf21 -0.59 -6.76 -0.38 8.57e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs9902453 0.967 rs9904336 chr17:28357080 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.1e-13 Coffee consumption (cups per day); CESC cis rs7923609 0.905 rs7092784 chr10:65214749 C/T cg01631684 chr10:65280961 REEP3 -0.43 -5.41 -0.32 1.4e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00116463 chr17:19266443 B9D1 0.63 6.76 0.38 8.88e-11 Gut microbiome composition (summer); CESC cis rs7572263 0.724 rs6704765 chr2:209054267 C/G cg23998903 chr2:209048830 C2orf80 -0.39 -5.14 -0.3 5.4e-7 Glioma;Non-glioblastoma glioma; CESC cis rs7726839 0.574 rs11134148 chr5:637107 C/T cg16447950 chr5:562315 NA -0.58 -6.05 -0.35 5e-9 Obesity-related traits; CESC cis rs4704187 0.687 rs1477934 chr5:74423243 A/T cg03227963 chr5:74354835 NA 0.31 5.68 0.33 3.52e-8 Response to amphetamines; CESC cis rs1050631 0.564 rs559289 chr18:33752890 A/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.59 8.23 0.45 8.37e-15 Esophageal squamous cell cancer (length of survival); CESC cis rs763014 0.833 rs3743904 chr16:632767 A/G cg00802000 chr16:706648 WDR90 -0.4 -6.02 -0.35 5.85e-9 Height; CESC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.85 0.39 5.17e-11 Bipolar disorder; CESC cis rs3733585 0.699 rs12498150 chr4:9950537 C/T cg02734326 chr4:10020555 SLC2A9 -0.4 -5.63 -0.33 4.67e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11690935 0.959 rs3770452 chr2:172668682 A/G cg13550731 chr2:172543902 DYNC1I2 -0.93 -14.4 -0.66 3.98e-35 Schizophrenia; CESC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg21144161 chr5:423903 AHRR 0.37 5.98 0.34 7.12e-9 Cystic fibrosis severity; CESC cis rs28595532 0.748 rs17594978 chr4:119336398 T/C cg21605333 chr4:119757512 SEC24D 1.01 5.58 0.32 5.98e-8 Cannabis dependence symptom count; CESC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg10691866 chr7:65817282 TPST1 0.32 5.53 0.32 7.79e-8 Aortic root size; CESC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg04234412 chr22:24373322 LOC391322 -0.52 -7.28 -0.41 3.7e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs34375054 0.525 rs1080910 chr12:125608492 T/C cg25124228 chr12:125621409 AACS -0.58 -7.32 -0.41 2.97e-12 Post bronchodilator FEV1/FVC ratio; CESC cis rs2380220 0.576 rs4368819 chr6:96031109 T/G cg04719120 chr6:96025338 MANEA 0.65 6.93 0.39 3.18e-11 Behavioural disinhibition (generation interaction); CESC cis rs7560272 0.723 rs6729468 chr2:73765253 C/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.88 -0.39 4.22e-11 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13137891 chr2:60779450 BCL11A -0.54 -6.39 -0.37 7.35e-10 Gut microbiome composition (summer); CESC cis rs9457247 0.765 rs9457252 chr6:167433925 A/G cg07741184 chr6:167504864 NA -0.36 -6.56 -0.37 2.76e-10 Crohn's disease; CESC cis rs8020095 0.528 rs10149615 chr14:67824290 T/C cg19548862 chr14:67692701 FAM71D -0.45 -5.34 -0.31 2.04e-7 Depression (quantitative trait); CESC cis rs6800768 0.633 rs6769403 chr3:24148622 T/C cg10674438 chr3:24145617 LOC152024 -0.47 -6.46 -0.37 5.08e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg27535305 chr1:53392650 SCP2 0.32 5.26 0.31 3.03e-7 Monocyte count; CESC cis rs7084402 0.967 rs7079648 chr10:60273155 C/A cg07615347 chr10:60278583 BICC1 -0.57 -8.84 -0.48 1.41e-16 Refractive error; CESC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg23281280 chr6:28129359 ZNF389 0.59 7.9 0.44 7.47e-14 Depression; CESC cis rs637571 0.522 rs493899 chr11:65747952 A/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.56 0.37 2.77e-10 Eosinophil percentage of white cells; CESC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg22535103 chr8:58192502 C8orf71 -0.85 -8.38 -0.46 3.08e-15 Developmental language disorder (linguistic errors); CESC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg14773178 chr5:1868261 NA 0.33 5.84 0.34 1.55e-8 Cardiovascular disease risk factors; CESC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg20151795 chr6:28129481 ZNF389 0.45 5.84 0.34 1.5e-8 Depression; CESC cis rs17641971 0.662 rs13268440 chr8:50000873 C/T cg00325661 chr8:49890786 NA 0.37 5.25 0.31 3.14e-7 Blood metabolite levels; CESC cis rs4853012 0.838 rs2177707 chr2:74356850 A/G cg20891558 chr2:74357851 NA 0.84 11.48 0.58 4.88e-25 Gestational age at birth (maternal effect); CESC cis rs7085104 0.572 rs284857 chr10:104574063 C/T cg04362960 chr10:104952993 NT5C2 -0.47 -6.36 -0.36 8.93e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg09323728 chr8:95962352 TP53INP1 -0.4 -8.68 -0.47 4.05e-16 Type 2 diabetes; CESC cis rs66573146 0.656 rs41410847 chr4:6957332 C/T cg00086871 chr4:6988644 TBC1D14 0.93 7.59 0.42 5.57e-13 Granulocyte percentage of myeloid white cells; CESC cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg15557168 chr22:42548783 NA -0.45 -6.97 -0.39 2.44e-11 Cognitive function; CESC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg04553112 chr3:125709451 NA -0.51 -5.36 -0.31 1.78e-7 Blood pressure (smoking interaction); CESC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg12463550 chr7:65579703 CRCP -0.62 -7.78 -0.43 1.65e-13 Aortic root size; CESC cis rs2243480 1.000 rs2420170 chr7:65656053 T/C cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.24e-32 Diabetic kidney disease; CESC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg27572855 chr1:25598939 RHD -0.44 -7.36 -0.41 2.34e-12 Erythrocyte sedimentation rate; CESC cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg12412775 chr1:25698385 RHCE -0.29 -5.18 -0.3 4.39e-7 Plateletcrit;Mean corpuscular volume; CESC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.21 0.4 5.88e-12 Height; CESC cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 6.05 0.35 4.83e-9 Tonsillectomy; CESC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg10691866 chr7:65817282 TPST1 0.34 5.32 0.31 2.17e-7 Aortic root size; CESC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg21782813 chr7:2030301 MAD1L1 0.44 6.15 0.35 2.79e-9 Bipolar disorder and schizophrenia; CESC cis rs3126085 0.935 rs11584427 chr1:152299788 A/G cg03465714 chr1:152285911 FLG 0.49 5.46 0.32 1.11e-7 Atopic dermatitis; CESC cis rs3762637 0.943 rs78429050 chr3:122252428 T/C cg24169773 chr3:122142474 KPNA1 -0.59 -6.85 -0.39 5.17e-11 LDL cholesterol levels; CESC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21815083 chr11:69458002 CCND1 0.57 6.28 0.36 1.37e-9 Gut microbiome composition (summer); CESC cis rs950169 0.881 rs34591918 chr15:84950833 C/T cg17507749 chr15:85114479 UBE2QP1 0.59 6.54 0.37 3.11e-10 Schizophrenia; CESC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg05368731 chr17:41323189 NBR1 0.79 10.91 0.56 4.06e-23 Menopause (age at onset); CESC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg17971929 chr21:40555470 PSMG1 1.06 16.52 0.71 1.26e-42 Cognitive function; CESC cis rs1784581 0.674 rs1789990 chr6:162406957 G/T cg17173639 chr6:162384350 PARK2 -0.62 -9.8 -0.52 1.45e-19 Itch intensity from mosquito bite; CESC cis rs7809950 0.954 rs2520242 chr7:107136320 G/T cg23024343 chr7:107201750 COG5 0.43 6.12 0.35 3.33e-9 Coronary artery disease; CESC cis rs889398 0.802 rs9940315 chr16:69876164 A/G cg09409435 chr16:70099608 PDXDC2 0.41 5.2 0.3 4e-7 Body mass index; CESC cis rs6430585 0.941 rs10496737 chr2:136540083 A/G cg07169764 chr2:136633963 MCM6 0.97 12.27 0.6 1.02e-27 Corneal structure; CESC cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg22875332 chr1:76189707 ACADM 0.65 7.68 0.43 3.04e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs116095464 0.558 rs62344345 chr5:257420 C/T cg20965017 chr5:231967 SDHA -0.47 -5.22 -0.31 3.61e-7 Breast cancer; CESC cis rs9914578 0.943 rs3760231 chr17:2014984 T/C cg16513277 chr17:2031491 SMG6 -0.62 -7.02 -0.4 1.86e-11 Body mass index; CESC cis rs6570726 0.935 rs436212 chr6:145849400 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.96e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2370759 1.000 rs11599522 chr10:32568434 G/C cg05361325 chr10:32636312 EPC1 -0.54 -5.14 -0.3 5.34e-7 Sexual dysfunction (female); CESC cis rs367615 0.959 rs17161951 chr5:108930590 A/G cg17395555 chr5:108820864 NA -0.45 -6.84 -0.39 5.5e-11 Colorectal cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15335805 chr11:10880038 ZBED5 0.52 6.0 0.35 6.4e-9 Gut microbiome composition (summer); CESC cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.78 8.92 0.48 7.63e-17 Alzheimer's disease; CESC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.41 3.05e-12 Developmental language disorder (linguistic errors); CESC cis rs4843747 0.671 rs4072871 chr16:88106614 C/T cg17633681 chr16:88106987 BANP 0.76 10.51 0.54 8.29e-22 Menopause (age at onset); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg02079880 chr6:157802436 ZDHHC14 0.52 6.59 0.38 2.31e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs113835537 0.935 rs57043177 chr11:66423147 A/G cg22134325 chr11:66188745 NPAS4 0.51 5.84 0.34 1.55e-8 Airway imaging phenotypes; CESC cis rs4843747 0.749 rs12102841 chr16:88072574 C/G cg17633681 chr16:88106987 BANP -0.69 -9.54 -0.51 9.94e-19 Menopause (age at onset); CESC cis rs9325144 0.647 rs11169189 chr12:39097078 A/T cg26384229 chr12:38710491 ALG10B -0.5 -6.94 -0.39 2.95e-11 Morning vs. evening chronotype; CESC cis rs1005277 0.540 rs11011351 chr10:38030525 A/G cg00409905 chr10:38381863 ZNF37A -0.5 -6.82 -0.39 6.27e-11 Extrinsic epigenetic age acceleration; CESC cis rs7223966 1.000 rs6504169 chr17:61709145 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.57 0.37 2.58e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs704010 0.543 rs10762841 chr10:80835684 G/C cg11504511 chr10:80827333 ZMIZ1;LOC283050 0.49 6.4 0.37 7.17e-10 Breast cancer; CESC cis rs7647973 0.626 rs4855845 chr3:49687043 T/C cg13072238 chr3:49761600 GMPPB -0.44 -5.4 -0.32 1.45e-7 Menarche (age at onset); CESC cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg17366294 chr4:99064904 C4orf37 0.56 7.7 0.43 2.65e-13 Colonoscopy-negative controls vs population controls; CESC cis rs9910055 0.529 rs170637 chr17:42186868 C/T cg13607699 chr17:42295918 UBTF -0.56 -7.36 -0.41 2.3e-12 Total body bone mineral density; CESC cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg11644478 chr21:40555479 PSMG1 0.72 7.71 0.43 2.56e-13 Cognitive function; CESC cis rs7264396 0.635 rs6119672 chr20:34479767 A/G cg17201900 chr20:34330562 RBM39 0.49 5.14 0.3 5.46e-7 Total cholesterol levels; CESC cis rs826838 1.000 rs826888 chr12:39104719 C/G cg26384229 chr12:38710491 ALG10B -0.62 -10.2 -0.53 7.78e-21 Heart rate; CESC cis rs2337406 0.866 rs4773949 chr14:107216306 C/T cg23076370 chr14:107095027 NA 0.5 5.18 0.3 4.35e-7 Alzheimer's disease (late onset); CESC cis rs2243480 1.000 rs316326 chr7:65609453 T/C cg18252515 chr7:66147081 NA -1.41 -14.48 -0.66 2.11e-35 Diabetic kidney disease; CESC cis rs863345 0.967 rs11264989 chr1:158469271 A/G cg12129480 chr1:158549410 OR10X1 -0.31 -6.19 -0.36 2.34e-9 Pneumococcal bacteremia; CESC cis rs9611565 0.838 rs4239894 chr22:41745548 C/G cg06634786 chr22:41940651 POLR3H -0.67 -6.99 -0.39 2.17e-11 Vitiligo; CESC trans rs4424809 0.614 rs76432167 chr13:85573798 C/T cg05918002 chr17:5019452 ZNF232 -0.63 -6.08 -0.35 4.29e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.32 5.66 0.33 3.89e-8 Electroencephalogram traits; CESC cis rs8027181 1.000 rs4777542 chr15:73082366 C/T cg25632853 chr15:73088954 NA -0.36 -6.21 -0.36 2.04e-9 Triglyceride levels; CESC cis rs4727027 0.899 rs4727025 chr7:148862863 A/G cg23158103 chr7:148848205 ZNF398 -0.42 -6.92 -0.39 3.45e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs854765 0.647 rs2056842 chr17:18009028 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.51 0.46 1.27e-15 Total body bone mineral density; CESC cis rs2635047 1.000 rs2635049 chr18:44687303 C/T cg19077165 chr18:44547161 KATNAL2 0.45 6.14 0.35 2.95e-9 Educational attainment; CESC cis rs61935443 0.832 rs11107771 chr12:95276844 A/G cg21533806 chr12:95267307 NA 0.58 7.13 0.4 9.52e-12 Schizophrenia; CESC cis rs7772486 0.875 rs9399573 chr6:146403255 A/T cg23711669 chr6:146136114 FBXO30 0.78 11.53 0.58 3.45e-25 Lobe attachment (rater-scored or self-reported); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03355190 chr15:40886188 CASC5 -0.48 -6.03 -0.35 5.55e-9 Asthma; CESC cis rs4722166 0.630 rs7781534 chr7:22778592 A/C cg13104385 chr7:22767384 IL6 0.48 6.43 0.37 5.96e-10 Lung cancer; CESC cis rs7524258 0.868 rs11120885 chr1:7306755 C/G cg07173049 chr1:7289937 CAMTA1 0.38 5.88 0.34 1.2e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg03467027 chr4:99064603 C4orf37 0.48 5.95 0.34 8.67e-9 Colonoscopy-negative controls vs population controls; CESC cis rs12545109 0.800 rs970838 chr8:57414806 A/G cg09654669 chr8:57350985 NA -0.46 -6.25 -0.36 1.67e-9 Obesity-related traits; CESC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg11494091 chr17:61959527 GH2 0.73 12.56 0.61 1.07e-28 Prudent dietary pattern; CESC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg07677032 chr17:61819896 STRADA 0.42 5.25 0.31 3.15e-7 Height; CESC cis rs5167 0.504 rs3760628 chr19:45457225 G/A cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.51e-10 Blood protein levels; CESC cis rs1949733 1.000 rs2688233 chr4:8491885 T/C cg11789530 chr4:8429930 ACOX3 0.8 11.25 0.57 2.93e-24 Response to antineoplastic agents; CESC cis rs11098499 0.754 rs9999724 chr4:120239944 C/T cg09307838 chr4:120376055 NA 0.8 11.03 0.56 1.55e-23 Corneal astigmatism; CESC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs77861329 0.702 rs7644325 chr3:52081136 A/G cg08692210 chr3:52188851 WDR51A 0.47 5.55 0.32 6.88e-8 Macrophage inflammatory protein 1b levels; CESC trans rs4332037 0.950 rs56403963 chr7:1946130 C/G cg11693508 chr17:37793320 STARD3 0.69 6.55 0.37 2.95e-10 Bipolar disorder; CESC cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg25554036 chr4:6271136 WFS1 0.52 8.6 0.47 7.07e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg23711669 chr6:146136114 FBXO30 0.94 14.33 0.66 7.07e-35 Lobe attachment (rater-scored or self-reported); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20566420 chr12:122327043 PSMD9 0.55 7.21 0.4 5.96e-12 Gut microbiota (bacterial taxa); CESC cis rs4319547 0.956 rs7316149 chr12:123063912 G/A cg05707623 chr12:122985044 ZCCHC8 -0.59 -6.81 -0.39 6.63e-11 Body mass index; CESC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg22963979 chr7:1858916 MAD1L1 -0.43 -5.87 -0.34 1.31e-8 Bipolar disorder and schizophrenia; CESC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg10691866 chr7:65817282 TPST1 0.31 5.33 0.31 2.06e-7 Aortic root size; CESC cis rs8005677 1.000 rs4981449 chr14:23388871 C/G cg25600027 chr14:23388339 RBM23 -0.43 -5.33 -0.31 2.08e-7 Cognitive ability (multi-trait analysis); CESC cis rs35740288 0.539 rs4843100 chr15:86339210 G/C cg20737812 chr15:86336631 KLHL25 -0.48 -5.48 -0.32 9.96e-8 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs2562784 0.638 rs2585056 chr15:84282215 C/G cg17507749 chr15:85114479 UBE2QP1 0.58 5.37 0.31 1.7e-7 Height; CESC cis rs67460515 0.892 rs16832082 chr3:161043571 A/G cg03342759 chr3:160939853 NMD3 -0.55 -7.9 -0.44 7.51e-14 Parkinson's disease; CESC cis rs56804039 1.000 rs7017341 chr8:8381664 C/A cg15556689 chr8:8085844 FLJ10661 -0.49 -5.28 -0.31 2.66e-7 Cervical cancer; CESC cis rs9549367 0.713 rs3024761 chr13:113824090 C/G cg00898013 chr13:113819073 PROZ 0.52 7.17 0.4 7.7e-12 Platelet distribution width; CESC cis rs329122 0.528 rs6891328 chr5:133851526 G/C cg26284174 chr5:133860141 NA 0.46 5.27 0.31 2.79e-7 Body mass index;Type 2 diabetes; CESC cis rs9287719 0.934 rs6432115 chr2:10748343 G/T cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25447359 chr22:30790057 NA -0.66 -7.99 -0.44 4.21e-14 Gut microbiome composition (summer); CESC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg06028605 chr16:24865363 SLC5A11 -0.53 -7.49 -0.42 1.03e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs11098499 0.865 rs28753180 chr4:120405367 A/T cg25214090 chr10:38739885 LOC399744 0.72 10.18 0.53 9.16e-21 Corneal astigmatism; CESC cis rs7208859 0.623 rs7223404 chr17:29107363 C/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4727027 0.625 rs75129390 chr7:148846775 T/A cg23158103 chr7:148848205 ZNF398 -0.4 -6.4 -0.37 7.14e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1950500 0.545 rs724165 chr14:24806229 G/A cg16194253 chr14:24768981 DHRS1;C14orf21 0.57 7.03 0.4 1.71e-11 Height; CESC cis rs7617773 0.779 rs77957078 chr3:48331286 G/C cg11946769 chr3:48343235 NME6 0.86 11.63 0.58 1.52e-25 Coronary artery disease; CESC cis rs3008870 0.755 rs4486425 chr1:67460791 T/C cg08660285 chr1:67390436 MIER1;WDR78 -0.63 -8.34 -0.46 4.16e-15 Lymphocyte percentage of white cells; CESC cis rs6460942 0.915 rs7803002 chr7:12306738 C/T cg20607287 chr7:12443886 VWDE -0.42 -5.98 -0.35 7.02e-9 Coronary artery disease; CESC cis rs9911578 1.000 rs302848 chr17:56686454 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.4 5.24 0.31 3.21e-7 Intelligence (multi-trait analysis); CESC cis rs4722166 0.695 rs56061963 chr7:22800397 T/C cg05265849 chr7:22767390 IL6 0.45 6.24 0.36 1.71e-9 Lung cancer; CESC trans rs208520 0.802 rs851600 chr6:66893754 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -11.17 -0.57 5.31e-24 Exhaled nitric oxide output; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07472647 chr5:149380356 HMGXB3;TIGD6 -0.45 -6.23 -0.36 1.85e-9 Fibrinogen levels; CESC cis rs6088580 0.634 rs6059905 chr20:33126946 T/C cg24642439 chr20:33292090 TP53INP2 0.52 6.8 0.39 6.84e-11 Glomerular filtration rate (creatinine); CESC cis rs2439831 0.850 rs16965120 chr15:44100342 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.66 0.43 3.45e-13 Lung cancer in ever smokers; CESC cis rs1975974 0.549 rs4889746 chr17:21745187 T/C cg18423549 chr17:21743878 NA -0.68 -9.74 -0.51 2.31e-19 Psoriasis; CESC trans rs2530545 0.851 rs1458549 chr7:34686792 A/C cg14080982 chr15:71736038 THSD4 0.45 6.03 0.35 5.56e-9 IgG glycosylation; CESC cis rs7077164 0.846 rs1227773 chr10:71579347 C/A cg20696214 chr10:71583771 COL13A1 -0.47 -6.44 -0.37 5.62e-10 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs1790761 0.505 rs7106423 chr11:67314144 A/G cg00290607 chr11:67383545 NA -0.36 -5.31 -0.31 2.3e-7 Mean corpuscular volume; CESC trans rs1814175 0.817 rs1996982 chr11:49972619 G/T cg15704280 chr7:45808275 SEPT13 -1.03 -21.34 -0.8 1.71e-59 Height; CESC cis rs6500395 1.000 rs1909765 chr16:48597358 A/G cg04672837 chr16:48644449 N4BP1 0.49 6.15 0.35 2.86e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs763121 0.524 rs760645 chr22:39032270 C/T cg06022373 chr22:39101656 GTPBP1 0.56 7.28 0.41 3.71e-12 Menopause (age at onset); CESC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg10691866 chr7:65817282 TPST1 -0.35 -5.77 -0.33 2.18e-8 Aortic root size; CESC cis rs4237845 0.773 rs6650217 chr12:58289072 T/G cg00677455 chr12:58241039 CTDSP2 0.44 5.78 0.33 2.09e-8 Intelligence (multi-trait analysis); CESC cis rs2075371 0.637 rs2544165 chr7:133920443 A/G cg20476274 chr7:133979776 SLC35B4 -0.62 -8.88 -0.48 1.05e-16 Mean platelet volume; CESC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg03647317 chr4:187891568 NA -0.37 -5.56 -0.32 6.44e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs1682361 1 rs1682361 chr3:136734014 G/C cg25687071 chr3:136751404 NA 0.4 5.37 0.31 1.73e-7 Schizophrenia; CESC cis rs6541297 0.938 rs1555289 chr1:230292499 C/T cg20703242 chr1:230279135 GALNT2 -0.67 -9.1 -0.49 2.25e-17 Coronary artery disease; CESC cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg22823121 chr1:150693482 HORMAD1 -0.39 -5.85 -0.34 1.45e-8 Tonsillectomy; CESC cis rs7605827 0.930 rs2111448 chr2:15599073 T/G cg19274914 chr2:15703543 NA 0.32 5.67 0.33 3.71e-8 Educational attainment (years of education); CESC cis rs2952156 0.652 rs11869286 chr17:37813856 C/G cg00129232 chr17:37814104 STARD3 -0.8 -12.06 -0.6 5.51e-27 Asthma; CESC trans rs9951602 0.512 rs3859325 chr18:76652175 A/G cg02800362 chr5:177631904 HNRNPAB 0.66 8.64 0.47 5.41e-16 Obesity-related traits; CESC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg08736216 chr1:53307985 ZYG11A 0.32 5.53 0.32 7.58e-8 Monocyte count; CESC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg25811766 chr13:21894605 NA 0.76 10.27 0.53 4.91e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs17021463 0.673 rs1609424 chr4:95301887 G/A cg11021082 chr4:95130006 SMARCAD1 0.49 6.15 0.35 2.79e-9 Testicular germ cell tumor; CESC trans rs877282 0.583 rs7072970 chr10:822757 G/A cg22713356 chr15:30763199 NA 1.07 9.68 0.51 3.6e-19 Uric acid levels; CESC cis rs977987 0.806 rs1364077 chr16:75396991 C/T cg03315344 chr16:75512273 CHST6 0.39 5.63 0.33 4.61e-8 Dupuytren's disease; CESC trans rs1728785 1.000 rs1170428 chr16:68603988 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.71 8.42 0.46 2.43e-15 Ulcerative colitis; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16741889 chr21:44280710 WDR4 -0.39 -6.18 -0.35 2.36e-9 Gambling; CESC cis rs8072100 0.967 rs3760370 chr17:45695832 C/T cg08085267 chr17:45401833 C17orf57 0.39 5.03 0.3 8.87e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs561341 0.882 rs111484028 chr17:30287701 G/A cg00745463 chr17:30367425 LRRC37B -0.7 -7.02 -0.4 1.85e-11 Hip circumference adjusted for BMI; CESC cis rs250677 0.522 rs55732303 chr5:148392538 C/T cg18129178 chr5:148520854 ABLIM3 -0.47 -5.22 -0.31 3.57e-7 Breast cancer; CESC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.49 -0.37 4.32e-10 Depression; CESC cis rs34779708 0.931 rs7923217 chr10:35309589 A/G cg04310649 chr10:35416472 CREM -0.53 -6.41 -0.37 6.57e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs936229 0.749 rs7497201 chr15:75190690 A/G cg14664628 chr15:75095509 CSK -0.72 -9.02 -0.48 3.93e-17 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg05368731 chr17:41323189 NBR1 0.75 10.32 0.54 3.35e-21 Menopause (age at onset); CESC cis rs9309473 0.950 rs13431529 chr2:73876041 G/C cg20560298 chr2:73613845 ALMS1 -0.53 -6.77 -0.38 8.13e-11 Metabolite levels; CESC cis rs7212590 0.655 rs8072050 chr17:58010972 G/A cg20303301 chr17:57937339 TUBD1 -0.55 -5.57 -0.32 6.25e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs6456156 0.586 rs10946208 chr6:167459596 C/T cg07741184 chr6:167504864 NA 0.34 5.88 0.34 1.21e-8 Primary biliary cholangitis; CESC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg22105103 chr4:187893119 NA 0.5 7.32 0.41 2.98e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7726839 0.718 rs6887972 chr5:597274 C/G cg16447950 chr5:562315 NA -0.49 -5.72 -0.33 2.88e-8 Obesity-related traits; CESC cis rs7100689 0.622 rs4933378 chr10:82147057 T/C cg00277334 chr10:82204260 NA -0.58 -7.62 -0.42 4.52e-13 Post bronchodilator FEV1; CESC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg11764359 chr7:65958608 NA -0.78 -11.64 -0.58 1.47e-25 Aortic root size; CESC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg19592336 chr6:28129416 ZNF389 0.59 7.73 0.43 2.24e-13 Depression; CESC cis rs2425143 1.000 rs11167275 chr20:34340275 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -7.45 -0.42 1.33e-12 Blood protein levels; CESC cis rs7809950 0.862 rs62482502 chr7:106987810 A/C cg23024343 chr7:107201750 COG5 -0.37 -5.15 -0.3 5.09e-7 Coronary artery disease; CESC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg16405210 chr4:1374714 KIAA1530 0.45 5.64 0.33 4.35e-8 Obesity-related traits; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg01258499 chr20:30540016 PDRG1 0.48 6.27 0.36 1.45e-9 Tetralogy of Fallot; CESC cis rs3008870 1.000 rs2755256 chr1:67471692 A/T cg08660285 chr1:67390436 MIER1;WDR78 1.03 14.0 0.65 1e-33 Lymphocyte percentage of white cells; CESC cis rs11690935 0.959 rs10166005 chr2:172607294 C/T cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.98 -0.68 3.73e-37 Schizophrenia; CESC cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg20607287 chr7:12443886 VWDE -0.77 -9.04 -0.49 3.38e-17 Coronary artery disease; CESC cis rs2073300 0.609 rs6137927 chr20:23372513 A/G cg12062639 chr20:23401060 NAPB 1.07 8.85 0.48 1.29e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1401999 1.000 rs1533684 chr3:183635815 A/G cg01324343 chr3:183735012 ABCC5 0.63 13.45 0.64 8.71e-32 Anterior chamber depth; CESC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.59 7.71 0.43 2.62e-13 Menopause (age at onset); CESC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg07507251 chr3:52567010 NT5DC2 0.42 7.15 0.4 8.2e-12 Bipolar disorder; CESC cis rs1600249 0.562 rs17153419 chr8:11394233 C/T cg21775007 chr8:11205619 TDH -0.39 -5.09 -0.3 6.74e-7 Rheumatoid arthritis; CESC cis rs35849525 1.000 rs35849525 chr3:50067350 T/C cg24308560 chr3:49941425 MST1R -0.56 -6.83 -0.39 5.8e-11 Intelligence (multi-trait analysis); CESC cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg03060546 chr3:49711283 APEH 0.43 5.34 0.31 2.05e-7 Parkinson's disease; CESC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.36 -0.31 1.82e-7 Total body bone mineral density; CESC cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.84 13.61 0.64 2.42e-32 Hip circumference adjusted for BMI; CESC cis rs710216 0.917 rs2297977 chr1:43415288 G/T cg03128534 chr1:43423976 SLC2A1 0.56 6.54 0.37 3.2e-10 Red cell distribution width; CESC cis rs4253772 0.513 rs6008700 chr22:46722560 C/T cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.5 5.19 0.3 4.27e-7 LDL cholesterol;Cholesterol, total; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10077144 chr16:3199858 NA -0.41 -6.39 -0.37 7.42e-10 Gambling; CESC cis rs16866061 1.000 rs16866061 chr2:225439844 A/G cg12698349 chr2:225449008 CUL3 0.77 11.29 0.57 2.16e-24 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg14393609 chr7:65229607 NA -0.52 -7.14 -0.4 8.84e-12 Aortic root size; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00515312 chr12:77158614 ZDHHC17 0.47 6.5 0.37 3.87e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.592 rs8779 chr22:42070276 T/C cg17376030 chr22:41985996 PMM1 -0.79 -8.55 -0.47 9.65e-16 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25300318 chr2:200527297 NA -0.54 -6.0 -0.35 6.47e-9 Gut microbiome composition (summer); CESC cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg18357526 chr6:26021779 HIST1H4A 0.66 8.67 0.47 4.36e-16 Intelligence (multi-trait analysis); CESC cis rs2249625 0.904 rs2496514 chr6:72904071 A/G cg18830697 chr6:72922368 RIMS1 -0.39 -5.58 -0.32 5.81e-8 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs7771547 0.573 rs544267 chr6:36398302 A/G cg07856975 chr6:36356162 ETV7 0.36 5.38 0.31 1.67e-7 Platelet distribution width; CESC cis rs7786877 0.500 rs2272572 chr7:100285888 C/T cg20848291 chr7:100343083 ZAN -0.81 -10.03 -0.52 2.88e-20 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24596729 chr1:165345813 NA 0.62 7.12 0.4 9.97e-12 Gut microbiome composition (summer); CESC cis rs6088580 0.660 rs6059893 chr20:33105897 T/G cg08999081 chr20:33150536 PIGU 0.66 11.5 0.58 4.31e-25 Glomerular filtration rate (creatinine); CESC trans rs1814175 0.817 rs10769613 chr11:49769692 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.93 -0.77 1.26e-54 Height; CESC cis rs7208859 0.673 rs11652370 chr17:29097223 G/A cg13385521 chr17:29058706 SUZ12P 0.59 5.46 0.32 1.09e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs911555 0.755 rs2756135 chr14:103962579 G/A cg12935359 chr14:103987150 CKB 0.67 9.78 0.52 1.73e-19 Intelligence (multi-trait analysis); CESC cis rs7223966 1.000 rs11870797 chr17:61804622 C/T cg11494091 chr17:61959527 GH2 0.38 5.19 0.3 4.28e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2708240 0.515 rs2708269 chr7:147595615 T/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.32 -5.68 -0.33 3.46e-8 QT interval (drug interaction); CESC cis rs9611565 0.918 rs7290404 chr22:41749796 C/T cg03806693 chr22:41940476 POLR3H -1.02 -11.89 -0.59 2.03e-26 Vitiligo; CESC cis rs7188697 0.922 rs1981961 chr16:58597291 A/T cg21335942 chr16:58549945 SETD6 -0.45 -5.2 -0.3 4.06e-7 QT interval; CESC cis rs2302190 0.882 rs7221464 chr17:56552353 A/T cg25885038 chr17:56607967 SEPT4 -0.41 -5.55 -0.32 6.92e-8 Vitamin D levels; CESC cis rs9911578 1.000 rs7216680 chr17:56988243 G/C cg05425664 chr17:57184151 TRIM37 -0.5 -6.83 -0.39 5.94e-11 Intelligence (multi-trait analysis); CESC cis rs10089 1.000 rs4836360 chr5:127458161 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.79 10.74 0.55 1.38e-22 Ileal carcinoids; CESC cis rs7937682 0.883 rs1613778 chr11:111456105 G/C cg09085632 chr11:111637200 PPP2R1B -0.93 -13.47 -0.64 7.49e-32 Primary sclerosing cholangitis; CESC cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -8.26 -0.45 6.9e-15 Monocyte percentage of white cells; CESC cis rs790123 0.933 rs812596 chr3:122382301 A/T cg17380795 chr3:122379686 NA 0.45 6.85 0.39 5.16e-11 Response to angiotensin II receptor blocker therapy; CESC cis rs7074356 0.523 rs7087728 chr10:82033470 G/A cg27171509 chr10:82033454 MAT1A -0.33 -5.1 -0.3 6.52e-7 Borderline personality disorder; CESC cis rs868036 0.609 rs28742003 chr15:68127769 C/T cg08079166 chr15:68083412 MAP2K5 0.41 5.58 0.32 5.86e-8 Restless legs syndrome; CESC trans rs3934047 0.869 rs12909073 chr15:82065902 A/G cg19098314 chr17:28804347 GOSR1 -0.43 -6.02 -0.35 5.83e-9 Response to paliperidone in schizophrenia (positive Marder score); CESC cis rs6693567 0.507 rs4970964 chr1:150458029 A/G cg09579323 chr1:150459698 TARS2 0.46 5.69 0.33 3.42e-8 Migraine; CESC cis rs2228479 0.850 rs2286393 chr16:89809548 C/A cg14709524 chr16:89940631 TCF25 0.84 6.38 0.36 7.86e-10 Skin colour saturation; CESC cis rs4243830 0.850 rs10779790 chr1:6608435 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -8.45 -0.46 1.93e-15 Body mass index; CESC cis rs1023500 0.505 rs2143139 chr22:42614401 G/C cg04733989 chr22:42467013 NAGA 0.68 10.01 0.52 3.26e-20 Schizophrenia; CESC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg00166722 chr3:10149974 C3orf24 0.5 6.31 0.36 1.19e-9 Alzheimer's disease; CESC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg24562669 chr7:97807699 LMTK2 0.48 7.1 0.4 1.13e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs116095464 0.558 rs7703803 chr5:292311 A/G cg10591111 chr5:226296 SDHA -0.53 -6.45 -0.37 5.35e-10 Breast cancer; CESC cis rs4332037 0.586 rs62442944 chr7:2015047 T/G cg23422044 chr7:1970798 MAD1L1 -0.49 -5.29 -0.31 2.6e-7 Bipolar disorder; CESC cis rs7537660 1.000 rs10888256 chr1:248004775 C/T cg12080717 chr1:248004886 OR11L1 -0.46 -5.71 -0.33 2.99e-8 Platelet distribution width; CESC cis rs8072100 0.840 rs1912482 chr17:45454883 G/A cg25173405 chr17:45401733 C17orf57 -0.43 -5.64 -0.33 4.46e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1559088 1.000 rs28803235 chr19:33561804 G/A cg17764715 chr19:33622953 WDR88 0.45 5.55 0.32 6.8e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg11766577 chr21:47581405 C21orf56 0.47 6.48 0.37 4.36e-10 Testicular germ cell tumor; CESC cis rs3126085 0.935 rs1353436 chr1:152172658 G/A cg03465714 chr1:152285911 FLG -0.43 -5.28 -0.31 2.72e-7 Atopic dermatitis; CESC cis rs7829975 0.714 rs6994038 chr8:8660538 C/A cg17143192 chr8:8559678 CLDN23 0.42 5.11 0.3 6.11e-7 Mood instability; CESC cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg21573476 chr21:45109991 RRP1B -0.42 -5.91 -0.34 1.04e-8 Mean corpuscular volume; CESC cis rs9311474 0.713 rs352165 chr3:52242902 A/G cg18099408 chr3:52552593 STAB1 -0.32 -5.44 -0.32 1.22e-7 Electroencephalogram traits; CESC cis rs4332037 0.664 rs73046334 chr7:1887037 T/C cg23422044 chr7:1970798 MAD1L1 -0.55 -5.93 -0.34 9.42e-9 Bipolar disorder; CESC cis rs2710642 0.540 rs11893614 chr2:62861661 A/G cg17519650 chr2:63277830 OTX1 0.47 5.54 0.32 7.36e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs362296 0.511 rs2051558 chr4:3324886 G/A cg08886695 chr4:3369023 RGS12 -0.42 -6.12 -0.35 3.4e-9 Parental longevity (mother's age at death); CESC cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg20476274 chr7:133979776 SLC35B4 -0.6 -8.35 -0.46 3.73e-15 Mean platelet volume; CESC cis rs9733 0.744 rs2039590 chr1:150813315 G/A cg22823121 chr1:150693482 HORMAD1 -0.4 -6.11 -0.35 3.6e-9 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12171159 chr11:72504902 STARD10 0.64 6.94 0.39 3.03e-11 Gut microbiome composition (summer); CESC trans rs9399401 1.000 rs972982 chr6:142666861 A/G cg02046995 chr22:41487740 EP300;MIR1281 -0.42 -6.06 -0.35 4.76e-9 Chronic obstructive pulmonary disease; CESC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.13 0.3 5.72e-7 Menopause (age at onset); CESC cis rs2742417 0.603 rs2742458 chr3:45767602 C/T cg04837898 chr3:45731254 SACM1L -0.47 -6.17 -0.35 2.54e-9 Response to anti-depressant treatment in major depressive disorder; CESC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg04282206 chr17:62833786 PLEKHM1P 0.54 6.41 0.37 6.78e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg11168104 chr5:1857477 NA -0.38 -5.72 -0.33 2.85e-8 Cardiovascular disease risk factors; CESC cis rs2645694 0.626 rs2703126 chr4:77819842 T/C cg10057126 chr4:77819792 ANKRD56 0.58 8.45 0.46 2.02e-15 Emphysema distribution in smoking; CESC cis rs959260 1.000 rs4788889 chr17:73389126 A/G cg12999837 chr17:73267436 MIF4GD -0.47 -5.48 -0.32 9.82e-8 Systemic lupus erythematosus; CESC cis rs7726839 0.561 rs72703050 chr5:582917 A/C cg16447950 chr5:562315 NA -0.55 -6.14 -0.35 3.06e-9 Obesity-related traits; CESC cis rs6693567 0.565 rs834234 chr1:150352494 C/G cg09579323 chr1:150459698 TARS2 -0.44 -6.0 -0.35 6.52e-9 Migraine; CESC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg14393609 chr7:65229607 NA 0.45 6.15 0.35 2.86e-9 Aortic root size; CESC cis rs12477438 0.798 rs7606635 chr2:99644782 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC trans rs877282 0.945 rs12767287 chr10:787310 A/G cg22713356 chr15:30763199 NA 1.31 13.31 0.63 2.78e-31 Uric acid levels; CESC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg15369054 chr17:80825471 TBCD 0.53 7.25 0.41 4.62e-12 Breast cancer; CESC cis rs67460515 0.563 rs16831886 chr3:160799830 A/C cg03342759 chr3:160939853 NMD3 -0.51 -6.31 -0.36 1.18e-9 Parkinson's disease; CESC cis rs17023223 0.537 rs6677107 chr1:119708765 C/T cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.97 0.39 2.54e-11 Depression; CESC cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg25554036 chr4:6271136 WFS1 -0.51 -8.5 -0.46 1.38e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs728616 0.558 rs12772945 chr10:82154496 C/T cg05935833 chr10:81318306 SFTPA2 -0.46 -5.67 -0.33 3.63e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs80130819 0.688 rs10783239 chr12:48616801 G/C cg05342945 chr12:48394962 COL2A1 -0.54 -5.61 -0.33 5.08e-8 Prostate cancer; CESC cis rs365132 0.934 rs149307 chr5:176471591 C/T cg16309518 chr5:176445507 NA -0.43 -6.32 -0.36 1.11e-9 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs2404602 0.692 rs35077207 chr15:76935306 A/G cg26408565 chr15:76604113 ETFA -0.38 -5.44 -0.32 1.21e-7 Blood metabolite levels; CESC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg21782813 chr7:2030301 MAD1L1 0.44 6.2 0.36 2.16e-9 Schizophrenia; CESC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg27121462 chr16:89883253 FANCA 0.79 11.83 0.59 3.38e-26 Vitiligo; CESC cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg02725872 chr8:58115012 NA -0.43 -5.8 -0.34 1.9e-8 Developmental language disorder (linguistic errors); CESC cis rs911555 0.755 rs12436729 chr14:103929889 G/C cg12935359 chr14:103987150 CKB 0.65 9.46 0.5 1.73e-18 Intelligence (multi-trait analysis); CESC cis rs3820068 0.705 rs72645803 chr1:15868232 G/A cg18192808 chr1:15853278 DNAJC16 0.46 5.44 0.32 1.2e-7 Systolic blood pressure; CESC cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg19052272 chr2:3704530 ALLC -0.47 -5.73 -0.33 2.72e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC trans rs61931739 0.534 rs10844729 chr12:34022919 A/G cg26384229 chr12:38710491 ALG10B 0.58 8.04 0.44 2.91e-14 Morning vs. evening chronotype; CESC cis rs7208859 0.623 rs609063 chr17:28951513 A/G cg13385521 chr17:29058706 SUZ12P 0.79 5.73 0.33 2.74e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3768617 0.510 rs10797842 chr1:183081867 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 13.7 0.64 1.14e-32 Fuchs's corneal dystrophy; CESC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg02951883 chr7:2050386 MAD1L1 -0.51 -6.85 -0.39 5.02e-11 Bipolar disorder and schizophrenia; CESC cis rs1775715 0.677 rs2491272 chr10:32186783 A/G cg18675610 chr10:32216311 ARHGAP12 0.34 5.21 0.3 3.84e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03933756 chr16:86565719 MTHFSD -0.56 -6.46 -0.37 4.95e-10 Gut microbiome composition (summer); CESC cis rs10242455 0.702 rs79878591 chr7:99082928 C/T cg25640893 chr7:99214727 ZNF498 1.15 7.03 0.4 1.74e-11 Blood metabolite levels; CESC cis rs9488822 0.676 rs6918059 chr6:116349041 C/T cg15226275 chr6:116381976 FRK 0.25 6.43 0.37 5.95e-10 Cholesterol, total;LDL cholesterol; CESC cis rs55728055 0.661 rs73162112 chr22:32045449 G/A cg01338084 chr22:32026380 PISD 1.29 8.72 0.47 3.17e-16 Age-related hearing impairment; CESC cis rs7818345 0.967 rs11786847 chr8:19277200 T/C cg11303988 chr8:19266685 CSGALNACT1 0.33 6.0 0.35 6.48e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs11098499 0.863 rs6858777 chr4:120475966 A/G cg24375607 chr4:120327624 NA 0.45 5.51 0.32 8.55e-8 Corneal astigmatism; CESC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.58 0.32 5.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12477438 0.501 rs2632260 chr2:99771590 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.04 0.68 2.28e-37 Chronic sinus infection; CESC cis rs2985684 0.948 rs7143010 chr14:50081803 T/C cg04989706 chr14:50066350 PPIL5 -0.47 -5.12 -0.3 5.98e-7 Carotid intima media thickness; CESC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.59 6.38 0.37 7.69e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11252926 0.661 rs7077209 chr10:484159 A/G cg18196295 chr10:418757 DIP2C -0.4 -5.49 -0.32 9.19e-8 Psychosis in Alzheimer's disease; CESC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg21724239 chr8:58056113 NA 0.57 5.9 0.34 1.08e-8 Developmental language disorder (linguistic errors); CESC cis rs644799 0.687 rs3748252 chr11:95519195 A/T cg03916912 chr11:95522834 CEP57;FAM76B -0.76 -10.79 -0.55 9.49e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg16144293 chr14:75469539 EIF2B2 0.39 5.04 0.3 8.49e-7 Height; CESC cis rs9910055 0.571 rs10208 chr17:42300278 C/T cg13607699 chr17:42295918 UBTF 0.92 15.36 0.69 1.59e-38 Total body bone mineral density; CESC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg17340268 chr14:105411764 AHNAK2 -0.52 -6.91 -0.39 3.56e-11 Rheumatoid arthritis; CESC trans rs6759922 1.000 rs11124322 chr2:22442392 G/A cg21162304 chr4:80247171 NAA11 0.37 6.04 0.35 5.2e-9 Subjective well-being (multi-trait analysis); CESC cis rs8180040 0.932 rs12490058 chr3:47529063 T/C cg27129171 chr3:47204927 SETD2 0.62 9.22 0.49 9.43e-18 Colorectal cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23039201 chr2:27851887 GPN1;CCDC121 -0.44 -6.4 -0.37 7.04e-10 Fibrinogen levels; CESC cis rs11214589 0.905 rs12804573 chr11:113241726 G/A cg14159747 chr11:113255604 NA 0.32 5.6 0.33 5.38e-8 Neuroticism; CESC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.69 -0.38 1.3e-10 Bipolar disorder; CESC cis rs7927592 0.956 rs12271290 chr11:68326236 A/G cg16797656 chr11:68205561 LRP5 -0.39 -5.47 -0.32 1.03e-7 Total body bone mineral density; CESC cis rs8180040 0.676 rs11130114 chr3:47154651 T/G cg27129171 chr3:47204927 SETD2 0.73 11.38 0.57 1.09e-24 Colorectal cancer; CESC cis rs711245 0.573 rs11899523 chr2:36800918 T/C cg09467607 chr2:36825704 FEZ2 0.6 10.46 0.54 1.12e-21 Height; CESC cis rs7662987 0.517 rs2602883 chr4:100040914 A/T cg12011299 chr4:100065546 ADH4 0.6 6.57 0.37 2.59e-10 Smoking initiation; CESC cis rs7927771 0.698 rs34467936 chr11:47915299 A/G cg05585544 chr11:47624801 NA -0.46 -6.93 -0.39 3.23e-11 Subjective well-being; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg02396668 chr19:50528878 VRK3;ZNF473 0.53 7.13 0.4 9.34e-12 Systemic lupus erythematosus; CESC cis rs6543140 0.964 rs6736135 chr2:103064924 A/G cg04239558 chr2:103089729 SLC9A4 0.45 5.58 0.32 6.06e-8 Blood protein levels; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg17541715 chr7:1216824 NA -0.39 -5.29 -0.31 2.63e-7 Longevity;Endometriosis; CESC cis rs950027 0.620 rs1145084 chr15:45675440 G/A cg21132104 chr15:45694354 SPATA5L1 0.67 8.55 0.46 1.01e-15 Response to fenofibrate (adiponectin levels); CESC cis rs12477438 0.798 rs13409996 chr2:99575497 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.4 -0.54 1.79e-21 Chronic sinus infection; CESC cis rs9479482 1.000 rs5017316 chr6:150333489 A/T cg25797454 chr6:150327115 RAET1K 0.27 5.23 0.31 3.43e-7 Alopecia areata; CESC cis rs9902453 0.740 rs1382391 chr17:28111986 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.34 -0.54 2.82e-21 Coffee consumption (cups per day); CESC cis rs6088580 0.524 rs6088552 chr20:33226491 A/G cg08999081 chr20:33150536 PIGU -0.46 -6.47 -0.37 4.84e-10 Glomerular filtration rate (creatinine); CESC cis rs12822507 0.831 rs34975957 chr12:12786190 G/A cg11838227 chr12:12764436 CREBL2 -0.4 -5.19 -0.3 4.2e-7 Systemic lupus erythematosus; CESC cis rs4927850 0.752 rs7624460 chr3:195748530 C/T cg12923728 chr3:195709715 SDHAP1 -0.69 -9.25 -0.49 7.99e-18 Pancreatic cancer; CESC cis rs2294693 0.947 rs742492 chr6:40996381 G/A cg14769373 chr6:40998127 UNC5CL -0.47 -6.58 -0.37 2.5e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs1707322 1.000 rs11211239 chr1:46451947 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs290268 0.838 rs1319677 chr9:93565999 A/G cg02608019 chr9:93564028 SYK 0.66 10.19 0.53 8.52e-21 Platelet count; CESC trans rs877282 1.000 rs11253361 chr10:770387 T/C cg22713356 chr15:30763199 NA 1.11 11.26 0.57 2.79e-24 Uric acid levels; CESC cis rs7107174 1.000 rs2511186 chr11:77984306 C/G cg02023728 chr11:77925099 USP35 0.48 6.86 0.39 4.75e-11 Testicular germ cell tumor; CESC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg20607287 chr7:12443886 VWDE -0.76 -10.63 -0.55 3.23e-22 Coronary artery disease; CESC cis rs2404602 0.692 rs1116535 chr15:77009514 C/G cg26408565 chr15:76604113 ETFA 0.39 5.76 0.33 2.29e-8 Blood metabolite levels; CESC cis rs909002 0.830 rs10914461 chr1:32113217 G/A cg13919466 chr1:32135498 COL16A1 -0.47 -8.51 -0.46 1.28e-15 Intelligence (multi-trait analysis); CESC trans rs1814175 0.541 rs12287397 chr11:49819799 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -20.12 -0.78 2.71e-55 Height; CESC cis rs7678296 1.000 rs7669536 chr4:37185787 C/T cg06805348 chr4:37245195 KIAA1239 0.45 5.18 0.3 4.45e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs1030877 0.515 rs17030766 chr2:105911905 G/A cg02079111 chr2:105885981 TGFBRAP1 -0.43 -5.67 -0.33 3.67e-8 Obesity-related traits; CESC cis rs66530629 0.917 rs4648879 chr1:25175246 A/G cg22509179 chr1:25234806 RUNX3 -0.45 -5.83 -0.34 1.62e-8 Plateletcrit; CESC cis rs7618501 1.000 rs7374183 chr3:49785133 G/A cg24308560 chr3:49941425 MST1R 0.51 6.96 0.39 2.69e-11 Intelligence (multi-trait analysis); CESC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg12963246 chr6:28129442 ZNF389 0.43 6.11 0.35 3.59e-9 Cardiac Troponin-T levels; CESC cis rs7824557 0.564 rs2736295 chr8:11234780 C/G cg21775007 chr8:11205619 TDH 0.52 7.55 0.42 7.08e-13 Retinal vascular caliber; CESC cis rs7429990 0.965 rs13074973 chr3:48028144 T/A cg11946769 chr3:48343235 NME6 -0.44 -5.37 -0.31 1.75e-7 Educational attainment (years of education); CESC cis rs721399 0.924 rs1115784 chr8:18255410 C/T cg18736775 chr8:18248649 NAT2 0.38 5.03 0.3 9.22e-7 Blood metabolite levels; CESC cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC cis rs1707322 1.000 rs34694458 chr1:46332696 G/A cg06784218 chr1:46089804 CCDC17 0.32 5.47 0.32 1.02e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs929596 0.785 rs6714634 chr2:234664765 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.62 7.73 0.43 2.22e-13 Total bilirubin levels in HIV-1 infection; CESC cis rs36051895 0.664 rs7852755 chr9:5100862 C/T cg02405213 chr9:5042618 JAK2 -0.52 -6.46 -0.37 5.04e-10 Pediatric autoimmune diseases; CESC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg16325326 chr1:53192061 ZYG11B 0.82 12.7 0.62 3.43e-29 Monocyte count; CESC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg16049864 chr8:95962084 TP53INP1 -0.64 -11.1 -0.56 9.32e-24 Type 2 diabetes; CESC cis rs12681288 0.862 rs7814070 chr8:1020991 A/G cg15309053 chr8:964076 NA 0.32 5.42 0.32 1.33e-7 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06057208 chr16:30535933 ZNF768 0.46 6.69 0.38 1.3100000000000001e-10 Fibrinogen levels; CESC cis rs1005277 0.522 rs11011343 chr10:38002698 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -9.74 -0.51 2.4e-19 Extrinsic epigenetic age acceleration; CESC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg03395511 chr6:291903 DUSP22 -0.72 -9.23 -0.49 9.24e-18 Menopause (age at onset); CESC cis rs9858542 0.953 rs9862080 chr3:49674458 A/G cg07274523 chr3:49395745 GPX1 0.68 8.72 0.47 3.23e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7208859 0.623 rs9914499 chr17:29107588 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2070488 0.965 rs9877282 chr3:38541452 A/G cg24069376 chr3:38537580 EXOG -0.48 -8.85 -0.48 1.31e-16 Electrocardiographic conduction measures; CESC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg07701084 chr6:150067640 NUP43 0.43 5.83 0.34 1.62e-8 Lung cancer; CESC cis rs9900062 0.546 rs2676294 chr17:62710764 A/G cg02598441 chr17:62777298 LOC146880 0.5 5.28 0.31 2.63e-7 QT interval; CESC cis rs2243480 1.000 rs56291018 chr7:65390339 G/A cg25894440 chr7:65020034 NA -0.62 -5.16 -0.3 4.73e-7 Diabetic kidney disease; CESC cis rs6545883 0.894 rs778148 chr2:61606866 G/A cg15711740 chr2:61764176 XPO1 0.42 5.39 0.31 1.57e-7 Tuberculosis; CESC cis rs6088580 0.668 rs1205340 chr20:32923871 G/A cg06115741 chr20:33292138 TP53INP2 -0.45 -5.67 -0.33 3.65e-8 Glomerular filtration rate (creatinine); CESC cis rs7520050 0.966 rs7539932 chr1:46292354 C/T cg03146154 chr1:46216737 IPP -0.48 -6.3 -0.36 1.25e-9 Red blood cell count;Reticulocyte count; CESC cis rs7116495 0.609 rs60054591 chr11:71825687 G/A cg07596299 chr11:71824057 C11orf51 0.79 5.03 0.3 9.06e-7 Severe influenza A (H1N1) infection; CESC cis rs5758659 0.657 rs5758587 chr22:42517636 C/G cg15557168 chr22:42548783 NA 0.43 6.72 0.38 1.11e-10 Cognitive function; CESC cis rs7615952 0.866 rs6438949 chr3:125650064 G/C cg05084668 chr3:125655381 ALG1L -0.54 -6.45 -0.37 5.41e-10 Blood pressure (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08498485 chr3:49711383 APEH 0.57 6.61 0.38 2.16e-10 Gut microbiome composition (summer); CESC cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.78 0.33 2.12e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs116095464 0.558 rs56127718 chr5:270273 G/T cg22496380 chr5:211416 CCDC127 -0.75 -8.61 -0.47 6.58e-16 Breast cancer; CESC cis rs847851 0.617 rs9394267 chr6:34960760 C/T cg13137465 chr6:34857473 ANKS1A -0.69 -7.19 -0.4 6.64e-12 Colonoscopy-negative controls vs population controls; CESC cis rs7144547 0.950 rs8004137 chr14:81884857 A/G cg02996355 chr14:81879375 NA -0.81 -9.23 -0.49 9e-18 Prudent dietary pattern; CESC cis rs796364 0.951 rs769952 chr2:200734368 C/T cg23649088 chr2:200775458 C2orf69 0.54 5.1 0.3 6.38e-7 Schizophrenia; CESC cis rs9291683 0.609 rs12507050 chr4:10007305 G/T cg00071950 chr4:10020882 SLC2A9 0.86 16.57 0.71 8.63e-43 Bone mineral density; CESC cis rs6922893 1.000 rs7449748 chr6:71660328 C/T cg10766373 chr6:71666121 B3GAT2 -0.34 -5.28 -0.31 2.7e-7 Obesity-related traits; CESC cis rs8067545 0.611 rs2158472 chr17:20171524 C/T cg13482628 chr17:19912719 NA -0.42 -5.62 -0.33 4.93e-8 Schizophrenia; CESC cis rs12681288 0.782 rs2123055 chr8:1029500 T/G cg04851639 chr8:1020857 NA -0.42 -8.74 -0.47 2.69e-16 Schizophrenia; CESC cis rs412050 0.947 rs239915 chr22:22316631 G/A cg17089214 chr22:22089827 YPEL1 0.65 6.03 0.35 5.37e-9 Attention deficit hyperactivity disorder; CESC cis rs9300255 0.544 rs2049114 chr12:123657338 T/C cg19016782 chr12:123741754 C12orf65 -0.43 -5.97 -0.34 7.66e-9 Neutrophil percentage of white cells; CESC cis rs9790314 1.000 rs336590 chr3:161079583 G/A cg04691961 chr3:161091175 C3orf57 -0.4 -5.04 -0.3 8.47e-7 Morning vs. evening chronotype; CESC cis rs7264396 0.836 rs2010565 chr20:34182517 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -7.1 -0.4 1.15e-11 Total cholesterol levels; CESC trans rs35110281 0.782 rs2329442 chr21:45041790 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 6.9 0.39 3.75e-11 Mean corpuscular volume; CESC cis rs8016982 0.698 rs8021385 chr14:81704682 G/A cg01989461 chr14:81687754 GTF2A1 0.68 10.36 0.54 2.42e-21 Schizophrenia; CESC cis rs7777484 0.534 rs2533890 chr7:2828743 C/T cg18446336 chr7:2847575 GNA12 -0.4 -6.51 -0.37 3.66e-10 Height; CESC cis rs9611565 0.765 rs132909 chr22:41802031 G/A cg06481639 chr22:41940642 POLR3H 0.62 6.52 0.37 3.49e-10 Vitiligo; CESC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.73 0.43 2.29e-13 Prudent dietary pattern; CESC trans rs7618501 1.000 rs695238 chr3:49869158 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.32 0.46 4.72e-15 Intelligence (multi-trait analysis); CESC cis rs7520050 0.966 rs4660898 chr1:46402171 A/G cg24296786 chr1:45957014 TESK2 0.43 5.39 0.31 1.59e-7 Red blood cell count;Reticulocyte count; CESC trans rs11098499 0.954 rs11729521 chr4:120416788 T/C cg25214090 chr10:38739885 LOC399744 0.72 10.09 0.53 1.85e-20 Corneal astigmatism; CESC cis rs3733418 0.860 rs13124015 chr4:165930282 G/A cg10852876 chr4:165953100 TRIM60 -0.5 -5.87 -0.34 1.29e-8 Obesity-related traits; CESC cis rs6762477 0.748 rs11717349 chr3:50223977 C/T cg24308560 chr3:49941425 MST1R 0.39 5.1 0.3 6.47e-7 Menarche (age at onset); CESC cis rs2425143 1.000 rs6060588 chr20:34337480 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -7.51 -0.42 9.19e-13 Blood protein levels; CESC cis rs7872515 0.536 rs10820938 chr9:94841980 C/T cg01248375 chr9:94877805 SPTLC1 0.65 5.25 0.31 3.15e-7 Bipolar disorder and schizophrenia; CESC cis rs3740713 1.000 rs73440614 chr11:18466700 C/G cg23797887 chr11:18477753 LDHAL6A -0.54 -5.24 -0.31 3.31e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs28647808 1.000 rs13940 chr9:136271546 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06134410 chr7:1705349 NA -0.42 -6.36 -0.36 8.81e-10 Gut microbiota (bacterial taxa); CESC cis rs7762018 0.891 rs12529402 chr6:170147675 A/T cg13891659 chr6:170190454 C6orf122;C6orf208 0.67 6.53 0.37 3.28e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC trans rs6951245 0.554 rs58210047 chr7:1149381 G/A cg13565492 chr6:43139072 SRF -0.76 -9.09 -0.49 2.43e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs826838 0.967 rs7970069 chr12:38810631 T/C cg26384229 chr12:38710491 ALG10B 0.83 14.57 0.67 1.05e-35 Heart rate; CESC cis rs10089 1.000 rs9968597 chr5:127455383 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 10.67 0.55 2.37e-22 Ileal carcinoids; CESC trans rs7615952 0.641 rs6805074 chr3:125772274 T/A cg07211511 chr3:129823064 LOC729375 -0.59 -6.53 -0.37 3.37e-10 Blood pressure (smoking interaction); CESC trans rs7246760 0.867 rs8112764 chr19:9748907 G/A cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs864537 0.676 rs1773560 chr1:167421763 A/G cg22356347 chr1:167427500 CD247 -0.39 -8.13 -0.45 1.61e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06521597 chr19:2783551 SGTA 0.58 6.52 0.37 3.47e-10 Gut microbiome composition (summer); CESC cis rs9467711 0.516 rs1324087 chr6:25841408 A/G cg08501292 chr6:25962987 TRIM38 -0.55 -5.79 -0.34 1.97e-8 Autism spectrum disorder or schizophrenia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01250699 chr8:22225185 SLC39A14 -0.51 -6.51 -0.37 3.75e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25772039 chr12:132329240 MMP17 -0.55 -6.38 -0.36 8.04e-10 Gut microbiome composition (summer); CESC cis rs1974653 0.781 rs175162 chr22:20113253 A/C cg12670310 chr22:20071307 DGCR8 -0.33 -5.04 -0.3 8.49e-7 Schizophrenia; CESC cis rs7617773 0.539 rs12486944 chr3:48390016 G/A cg11946769 chr3:48343235 NME6 0.62 7.86 0.43 9.99e-14 Coronary artery disease; CESC cis rs3733585 0.699 rs28837683 chr4:9959808 C/T cg11266682 chr4:10021025 SLC2A9 -0.6 -11.22 -0.57 3.77e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg07701084 chr6:150067640 NUP43 0.47 6.77 0.38 8.49e-11 Lung cancer; CESC cis rs2735413 0.918 rs12925605 chr16:78071715 G/A cg04733911 chr16:78082701 NA -0.54 -9.16 -0.49 1.47e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs9457247 0.544 rs6920858 chr6:167464630 G/A cg07741184 chr6:167504864 NA 0.37 6.49 0.37 4.2e-10 Crohn's disease; CESC cis rs3105593 1.000 rs57002197 chr15:50873760 C/T cg08437265 chr15:50716283 USP8 0.42 5.33 0.31 2.09e-7 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17322163 chr12:51632344 DAZAP2 0.61 6.86 0.39 4.87e-11 Gut microbiome composition (summer); CESC cis rs2011503 1.000 rs8110250 chr19:19559989 G/A cg11584989 chr19:19387371 SF4 0.62 7.22 0.41 5.51e-12 Bipolar disorder; CESC cis rs1799949 0.864 rs60309406 chr17:41435665 C/T cg23758822 chr17:41437982 NA 1.05 16.11 0.7 3.64e-41 Menopause (age at onset); CESC cis rs2412819 0.597 rs78282429 chr15:43922003 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.51 6.46 0.37 4.98e-10 Lung cancer; CESC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg22467129 chr15:76604101 ETFA -0.39 -6.0 -0.35 6.37e-9 Blood metabolite levels; CESC cis rs11122272 0.735 rs2739513 chr1:231515201 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.04 -0.44 3.04e-14 Hemoglobin concentration; CESC cis rs941873 0.772 rs1892498 chr10:81103862 A/G cg11057378 chr10:81107060 PPIF 0.34 5.37 0.31 1.75e-7 Height; CESC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg11494091 chr17:61959527 GH2 0.73 12.52 0.61 1.45e-28 Prudent dietary pattern; CESC cis rs863345 1.000 rs863352 chr1:158539006 A/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.38 -0.36 7.97e-10 Pneumococcal bacteremia; CESC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs73206853 0.764 rs73206868 chr12:110816835 G/T cg12870014 chr12:110450643 ANKRD13A 0.63 5.23 0.31 3.48e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2204008 0.658 rs12371956 chr12:38298010 A/T cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Bladder cancer; CESC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg18876405 chr7:65276391 NA 0.47 5.3 0.31 2.45e-7 Aortic root size; CESC cis rs9467160 1.000 rs9461011 chr6:24440351 C/T cg20631270 chr6:24437470 GPLD1 -0.46 -5.84 -0.34 1.56e-8 Liver enzyme levels; CESC cis rs7296418 0.885 rs1716184 chr12:123637509 G/C cg05973401 chr12:123451056 ABCB9 0.53 6.75 0.38 9.03e-11 Platelet count; CESC cis rs2243480 1.000 rs13247184 chr7:65358928 A/G cg13147721 chr7:65941812 NA -0.9 -8.76 -0.47 2.35e-16 Diabetic kidney disease; CESC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg08470875 chr2:26401718 FAM59B -0.76 -8.06 -0.44 2.69e-14 Gut microbiome composition (summer); CESC cis rs9457247 1.000 rs448060 chr6:167382622 A/G cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.76e-8 Crohn's disease; CESC cis rs763014 0.865 rs4006748 chr16:632225 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC cis rs10097731 0.901 rs28505206 chr8:82044410 A/G cg25230327 chr8:82042993 NA -0.56 -6.29 -0.36 1.32e-9 Serum total protein level; CESC cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.57 0.32 6.41e-8 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs10089 0.904 rs2195921 chr5:127489754 A/C cg19767477 chr5:127420684 SLC12A2 -0.39 -5.08 -0.3 7.15e-7 Ileal carcinoids; CESC cis rs5167 0.504 rs3760629 chr19:45458146 A/C cg13119609 chr19:45449297 APOC2 0.45 7.36 0.41 2.29e-12 Blood protein levels; CESC cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs11871801 0.517 rs645692 chr17:40701073 C/T cg16308533 chr17:40838983 CNTNAP1 0.4 5.21 0.3 3.85e-7 Crohn's disease; CESC trans rs66573146 1.000 rs9942188 chr4:6984181 C/T cg07817883 chr1:32538562 TMEM39B 1.36 8.97 0.48 5.47e-17 Granulocyte percentage of myeloid white cells; CESC cis rs4722166 0.630 rs1581497 chr7:22779503 C/A cg05265849 chr7:22767390 IL6 0.57 7.11 0.4 1.06e-11 Lung cancer; CESC cis rs897984 0.806 rs11640534 chr16:30949515 G/A cg00531865 chr16:30841666 NA 0.5 6.92 0.39 3.43e-11 Dementia with Lewy bodies; CESC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg21724239 chr8:58056113 NA 0.67 9.03 0.49 3.58e-17 Developmental language disorder (linguistic errors); CESC cis rs3741798 1.000 rs78807762 chr12:12484136 G/A cg08615371 chr12:12503544 MANSC1 0.89 6.41 0.37 6.53e-10 Cerebrospinal fluid biomarker levels; CESC cis rs9457247 1.000 rs364283 chr6:167383750 C/T cg23791538 chr6:167370224 RNASET2 -0.6 -8.65 -0.47 5.12e-16 Crohn's disease; CESC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.37 -0.5 3.42e-18 Alzheimer's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02430089 chr12:100661568 SCYL2;DEPDC4 -0.49 -6.7 -0.38 1.28e-10 Gut microbiota (bacterial taxa); CESC cis rs644799 1.000 rs12786522 chr11:95522858 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.89 0.39 4e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.35 -0.57 1.35e-24 Type 2 diabetes; CESC trans rs7188861 0.681 rs12927773 chr16:11403963 G/T cg22142858 chr6:6004804 NRN1 -0.43 -6.17 -0.35 2.6e-9 HDL cholesterol; CESC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg25072359 chr17:41440525 NA 0.48 6.44 0.37 5.69e-10 Menopause (age at onset); CESC cis rs3020736 0.500 rs6002603 chr22:42492362 C/G cg12850546 chr22:42539477 CYP2D7P1 0.44 5.23 0.31 3.44e-7 Autism spectrum disorder or schizophrenia; CESC trans rs61931739 0.534 rs2625897 chr12:34064295 G/A cg26384229 chr12:38710491 ALG10B 0.52 6.96 0.39 2.64e-11 Morning vs. evening chronotype; CESC cis rs8020095 0.528 rs6573765 chr14:67756236 T/C cg19548862 chr14:67692701 FAM71D -0.49 -6.04 -0.35 5.3300000000000004e-09 Depression (quantitative trait); CESC cis rs7904368 0.754 rs7076955 chr10:16852781 G/A cg23933602 chr10:16859644 RSU1 0.74 7.29 0.41 3.68e-12 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs896854 0.517 rs10112447 chr8:95955701 C/T cg23172400 chr8:95962367 TP53INP1 -0.4 -7.31 -0.41 3.18e-12 Type 2 diabetes; CESC cis rs1348850 0.914 rs10194648 chr2:178337031 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.83 11.66 0.58 1.27e-25 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 13.0 0.62 3.18e-30 Personality dimensions; CESC cis rs2180341 0.618 rs6683 chr6:127610021 G/A cg24812749 chr6:127587940 RNF146 0.6 8.1 0.45 2.05e-14 Breast cancer; CESC trans rs2018683 1.000 rs160837 chr7:29012732 C/G cg19402173 chr7:128379420 CALU -0.7 -9.52 -0.5 1.11e-18 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg18765753 chr7:1198926 ZFAND2A -0.47 -5.86 -0.34 1.34e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs60843830 1.000 rs7566279 chr2:281178 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.88 11.87 0.59 2.33e-26 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg06212747 chr3:49208901 KLHDC8B 0.68 8.05 0.44 2.84e-14 Menarche (age at onset); CESC cis rs1018836 0.892 rs13267237 chr8:91550820 T/C cg16814680 chr8:91681699 NA -0.66 -9.41 -0.5 2.41e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.6 0.51 6.43e-19 Platelet count; CESC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg17178900 chr1:205818956 PM20D1 0.91 16.02 0.7 7.38e-41 Menarche (age at onset); CESC cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg25427524 chr10:38739819 LOC399744 -0.64 -9.23 -0.49 8.69e-18 Extrinsic epigenetic age acceleration; CESC cis rs1957429 0.614 rs73279823 chr14:65351315 A/G cg23373153 chr14:65346875 NA -0.92 -6.7 -0.38 1.21e-10 Pediatric areal bone mineral density (radius); CESC cis rs6693567 0.545 rs6664703 chr1:150459087 G/C cg09579323 chr1:150459698 TARS2 0.44 5.52 0.32 8.21e-8 Migraine; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg05310071 chr17:16120569 PIGL 0.44 6.28 0.36 1.4e-9 Attention deficit hyperactivity disorder; CESC cis rs710216 0.827 rs841850 chr1:43402054 T/C cg03128534 chr1:43423976 SLC2A1 0.44 5.13 0.3 5.73e-7 Red cell distribution width; CESC cis rs9911578 1.000 rs9902994 chr17:56948722 T/A cg05425664 chr17:57184151 TRIM37 -0.5 -6.96 -0.39 2.6e-11 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg17809632 chr2:27435717 SLC5A6;C2orf28 0.45 6.37 0.36 8.2e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25798026 chr22:32149910 DEPDC5 0.59 6.69 0.38 1.35e-10 Gut microbiome composition (summer); CESC cis rs3760982 0.585 rs61013802 chr19:44292142 A/T cg11993925 chr19:44307056 LYPD5 0.33 5.48 0.32 9.7e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.86 8.83 0.48 1.43e-16 Platelet count; CESC cis rs3806843 0.966 rs11958868 chr5:140201420 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.15 -0.3 4.97e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2415984 0.562 rs34368760 chr14:46928532 T/A cg14871534 chr14:47121158 RPL10L 0.39 5.73 0.33 2.76e-8 Number of children ever born; CESC cis rs116095464 0.510 rs60844864 chr5:267000 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.29 0.31 2.58e-7 Breast cancer; CESC cis rs2073300 0.609 rs6137945 chr20:23406136 C/T cg12062639 chr20:23401060 NAPB 1.06 8.23 0.45 8.54e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs35123781 0.696 rs356433 chr5:139071193 C/T cg10513866 chr5:139070639 NA 0.43 6.09 0.35 3.88e-9 Schizophrenia; CESC cis rs116095464 0.614 rs56299325 chr5:220594 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.74 0.33 2.63e-8 Breast cancer; CESC cis rs41271473 0.526 rs72765760 chr1:228743222 G/A cg10167378 chr1:228756711 NA 0.51 5.28 0.31 2.73e-7 Chronic lymphocytic leukemia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07905888 chr1:36023245 NCDN;KIAA0319L -0.47 -6.04 -0.35 5.23e-9 Ulcerative colitis; CESC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg00745463 chr17:30367425 LRRC37B -0.6 -5.81 -0.34 1.8e-8 Hip circumference adjusted for BMI; CESC cis rs3733585 0.781 rs6449183 chr4:9970691 C/A cg11266682 chr4:10021025 SLC2A9 -0.61 -12.17 -0.6 2.26e-27 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7937682 0.889 rs1784787 chr11:111486125 T/A cg22437258 chr11:111473054 SIK2 0.72 9.66 0.51 4.24e-19 Primary sclerosing cholangitis; CESC cis rs7208859 0.673 rs216424 chr17:28943064 T/G cg14008862 chr17:28927542 LRRC37B2 0.79 7.07 0.4 1.34e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7089973 0.604 rs55759483 chr10:116573423 T/C cg25233709 chr10:116636983 FAM160B1 0.36 5.86 0.34 1.39e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs2294693 0.947 rs6924722 chr6:41002195 C/T cg14769373 chr6:40998127 UNC5CL 0.4 5.79 0.34 1.99e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs2197308 0.692 rs1904964 chr12:37933241 T/A cg13010199 chr12:38710504 ALG10B 0.5 6.45 0.37 5.2e-10 Morning vs. evening chronotype; CESC cis rs9467711 0.539 rs34436535 chr6:26370365 G/C cg12826209 chr6:26865740 GUSBL1 0.62 5.22 0.31 3.66e-7 Autism spectrum disorder or schizophrenia; CESC cis rs36093924 0.646 rs4822069 chr22:42351481 T/C cg15557168 chr22:42548783 NA 0.37 5.39 0.31 1.58e-7 Intelligence; CESC cis rs854765 0.964 rs854810 chr17:18006421 G/C cg04398451 chr17:18023971 MYO15A 0.67 9.35 0.5 3.75e-18 Total body bone mineral density; CESC cis rs2637266 1.000 rs755824 chr10:78381348 A/G cg18941641 chr10:78392320 NA 0.43 8.31 0.45 4.85e-15 Pulmonary function; CESC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.77 -0.33 2.2e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs863345 0.967 rs7512117 chr1:158532064 C/T cg12129480 chr1:158549410 OR10X1 -0.33 -6.65 -0.38 1.62e-10 Pneumococcal bacteremia; CESC cis rs77861329 0.920 rs9860982 chr3:52096432 T/C cg08692210 chr3:52188851 WDR51A 0.8 7.04 0.4 1.61e-11 Macrophage inflammatory protein 1b levels; CESC cis rs807669 0.802 rs762528 chr22:19166680 A/G cg02655711 chr22:19163373 SLC25A1 0.99 14.8 0.67 1.54e-36 Metabolite levels; CESC cis rs1401999 1.000 rs6805913 chr3:183662924 T/G cg01324343 chr3:183735012 ABCC5 0.63 13.49 0.64 6.42e-32 Anterior chamber depth; CESC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg10691866 chr7:65817282 TPST1 -0.33 -5.39 -0.31 1.58e-7 Aortic root size; CESC cis rs4243830 0.850 rs7536908 chr1:6607814 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.78 -7.77 -0.43 1.78e-13 Body mass index; CESC cis rs910316 0.967 rs175498 chr14:75536369 G/A cg08847533 chr14:75593920 NEK9 -0.96 -17.69 -0.74 8.96e-47 Height; CESC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg19346786 chr7:2764209 NA 0.49 7.12 0.4 9.94e-12 Height; CESC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg25072359 chr17:41440525 NA 0.49 7.15 0.4 8.55e-12 Menopause (age at onset); CESC cis rs5753618 0.561 rs4141404 chr22:31675185 A/C cg00478049 chr22:31556069 RNF185 0.46 5.21 0.3 3.75e-7 Colorectal cancer; CESC cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg05890377 chr2:74357713 NA 0.77 10.5 0.54 8.77e-22 Gestational age at birth (maternal effect); CESC cis rs8067545 0.611 rs1373146 chr17:20206675 G/A cg13482628 chr17:19912719 NA -0.42 -5.61 -0.33 5.2e-8 Schizophrenia; CESC cis rs4481887 0.708 rs6696691 chr1:248539720 T/C cg26353448 chr1:248524236 OR2T4 -0.37 -5.27 -0.31 2.78e-7 Common traits (Other); CESC cis rs6893300 0.961 rs62406219 chr5:179211629 G/A cg14593053 chr5:179126677 CANX -0.53 -5.94 -0.34 9.17e-9 Resting heart rate; CESC cis rs1538970 0.748 rs11211137 chr1:46013892 T/A cg06784218 chr1:46089804 CCDC17 0.41 6.36 0.36 8.76e-10 Platelet count; CESC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg23161317 chr6:28129485 ZNF389 0.51 6.53 0.37 3.27e-10 Parkinson's disease; CESC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg25985355 chr7:65971099 NA 0.33 5.52 0.32 7.94e-8 Aortic root size; CESC cis rs992157 0.697 rs13384682 chr2:219069137 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.68 9.56 0.51 8.5e-19 Colorectal cancer; CESC cis rs2289583 0.517 rs2004278 chr15:75264363 C/T cg14664628 chr15:75095509 CSK 0.52 6.07 0.35 4.51e-9 Systemic lupus erythematosus; CESC cis rs2011503 0.882 rs10423874 chr19:19359500 C/G cg11584989 chr19:19387371 SF4 0.54 6.53 0.37 3.31e-10 Bipolar disorder; CESC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg16680214 chr1:154839983 KCNN3 -0.44 -6.76 -0.38 8.73e-11 Prostate cancer; CESC cis rs561341 0.609 rs4795659 chr17:30187139 C/G cg13647721 chr17:30228624 UTP6 -0.74 -8.56 -0.47 9.61e-16 Hip circumference adjusted for BMI; CESC cis rs11864453 0.647 rs10492814 chr16:72126514 G/A cg16558253 chr16:72132732 DHX38 -0.55 -8.54 -0.46 1.08e-15 Fibrinogen levels; CESC cis rs4474465 0.850 rs10899539 chr11:78243743 T/C cg27205649 chr11:78285834 NARS2 0.43 5.41 0.32 1.41e-7 Alzheimer's disease (survival time); CESC cis rs1451375 0.617 rs10267323 chr7:50591424 A/G cg14593290 chr7:50529359 DDC 0.49 5.9 0.34 1.12e-8 Malaria; CESC cis rs6540556 0.723 rs12090931 chr1:209889601 A/G cg05527609 chr1:210001259 C1orf107 -0.67 -7.36 -0.41 2.32e-12 Red blood cell count; CESC trans rs2207136 0.835 rs11970011 chr6:50845787 T/C cg06522515 chr3:184090630 THPO -0.37 -6.48 -0.37 4.51e-10 Myopia; CESC cis rs11723261 0.546 rs4315728 chr4:141021 T/C cg12746427 chr4:53362 ZNF718;ZNF595 0.43 5.11 0.3 6.24e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs2790457 0.958 rs2807754 chr10:28887192 C/T cg04045419 chr10:28823091 WAC -0.43 -5.2 -0.3 4.07e-7 Multiple myeloma; CESC cis rs3105593 1.000 rs12438305 chr15:50912454 G/C cg08437265 chr15:50716283 USP8 0.41 5.34 0.31 2.05e-7 QT interval; CESC cis rs6088580 0.634 rs6141471 chr20:33006730 A/G cg06115741 chr20:33292138 TP53INP2 -0.47 -6.03 -0.35 5.36e-9 Glomerular filtration rate (creatinine); CESC cis rs5758659 0.652 rs133347 chr22:42423645 A/T cg05082376 chr22:42548792 NA -0.38 -5.65 -0.33 4.06e-8 Cognitive function; CESC cis rs1538970 0.961 rs884962 chr1:45847981 G/A cg06784218 chr1:46089804 CCDC17 0.34 5.76 0.33 2.3e-8 Platelet count; CESC cis rs1322639 0.614 rs9364356 chr6:169567108 G/A cg03254818 chr6:169586852 NA 0.54 5.55 0.32 6.83e-8 Pulse pressure; CESC cis rs10254118 0.757 rs13241123 chr7:133135507 A/T cg10665199 chr7:133106180 EXOC4 0.58 7.77 0.43 1.68e-13 Intelligence (multi-trait analysis); CESC cis rs9858542 0.953 rs9811982 chr3:49624377 A/C cg07274523 chr3:49395745 GPX1 0.64 8.15 0.45 1.42e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.44 0.46 2.17e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg08564027 chr20:61660810 NA 0.9 15.42 0.69 9.97e-39 Prostate cancer (SNP x SNP interaction); CESC cis rs4888262 0.526 rs4887777 chr16:74637821 A/G cg01733217 chr16:74700730 RFWD3 0.86 11.9 0.59 1.96e-26 Testicular germ cell tumor; CESC cis rs1008375 0.898 rs9998130 chr4:17593905 A/G cg27347728 chr4:17578864 LAP3 0.49 5.54 0.32 7.34e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9584850 0.834 rs3803253 chr13:99117149 G/A cg22223119 chr13:99095684 FARP1 -0.36 -5.11 -0.3 6.19e-7 Neuroticism; CESC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg19077165 chr18:44547161 KATNAL2 -0.6 -9.17 -0.49 1.4e-17 Personality dimensions; CESC cis rs2242116 0.796 rs2290546 chr3:46965197 C/G cg27129171 chr3:47204927 SETD2 0.53 6.75 0.38 9.29e-11 Birth weight; CESC cis rs6087990 0.899 rs1003521 chr20:31366598 T/C cg13636640 chr20:31349939 DNMT3B 0.9 15.74 0.7 7.54e-40 Ulcerative colitis; CESC cis rs7178572 0.568 rs4886862 chr15:77652368 T/C cg22256960 chr15:77711686 NA -0.52 -6.55 -0.37 3.02e-10 Type 2 diabetes; CESC cis rs2980439 0.525 rs2945238 chr8:8170136 A/C cg06636001 chr8:8085503 FLJ10661 0.52 6.45 0.37 5.27e-10 Neuroticism; CESC cis rs1953600 0.645 rs7071579 chr10:81910278 A/G cg04850286 chr10:81895943 PLAC9 0.3 5.2 0.3 3.98e-7 Sarcoidosis; CESC trans rs459571 1.000 rs2810489 chr9:136922700 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.66 -8.63 -0.47 5.61e-16 Platelet distribution width; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20354231 chr13:53171401 NA 0.4 6.22 0.36 1.89e-9 Gambling; CESC cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg18198730 chr1:247681584 NA 0.62 7.73 0.43 2.22e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs7084402 0.967 rs1658439 chr10:60325986 A/G cg07615347 chr10:60278583 BICC1 0.61 9.55 0.51 8.96e-19 Refractive error; CESC cis rs4803468 0.967 rs4803461 chr19:41908871 G/A cg14132834 chr19:41945861 ATP5SL -0.56 -7.01 -0.4 2.03e-11 Height; CESC cis rs28647808 1.000 rs4962143 chr9:136275137 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs4889855 0.556 rs4890043 chr17:78526831 C/T cg16591659 chr17:78472290 NA 0.35 5.82 0.34 1.71e-8 Fractional excretion of uric acid; CESC cis rs477692 0.870 rs532248 chr10:131414156 T/A cg05714579 chr10:131428358 MGMT 0.5 7.01 0.4 2.02e-11 Response to temozolomide; CESC cis rs6575793 0.553 rs7140556 chr14:101036458 G/T cg18516195 chr14:101012996 BEGAIN 0.42 5.25 0.31 3.05e-7 Menarche (age at onset); CESC cis rs1506636 0.962 rs2456551 chr7:123394610 C/G cg03229431 chr7:123269106 ASB15 0.52 6.99 0.39 2.25e-11 Plateletcrit;Platelet count; CESC trans rs1814175 0.765 rs1794141 chr11:49914135 G/C cg03929089 chr4:120376271 NA -0.93 -16.26 -0.71 1.03e-41 Height; CESC cis rs2249625 0.545 rs2463743 chr6:72874741 C/T cg18830697 chr6:72922368 RIMS1 -0.48 -7.16 -0.4 7.86e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs7017914 0.934 rs17689585 chr8:71818801 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.45 -5.78 -0.33 2.1e-8 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00597555 chr15:90177036 KIF7 -0.6 -6.52 -0.37 3.64e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.729 rs203320 chr22:41913477 T/C cg06634786 chr22:41940651 POLR3H -0.45 -5.21 -0.3 3.76e-7 Vitiligo; CESC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg15445000 chr17:37608096 MED1 -0.39 -6.45 -0.37 5.31e-10 Glomerular filtration rate (creatinine); CESC cis rs10899021 0.915 rs11236198 chr11:74372200 G/T cg25880958 chr11:74394337 NA -0.73 -7.26 -0.41 4.38e-12 Response to metformin (IC50); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15450734 chr14:103541957 NA -0.51 -7.46 -0.42 1.26e-12 Gambling; CESC cis rs4906332 0.901 rs4900575 chr14:103899169 G/C cg09975044 chr14:104007538 NA 0.47 6.4 0.37 6.89e-10 Coronary artery disease; CESC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 11.24 0.57 3.07e-24 Platelet count; CESC cis rs10771431 0.935 rs1988852 chr12:9372862 G/A cg08997352 chr12:9597637 DDX12 -0.67 -8.9 -0.48 9.17e-17 Breast size; CESC cis rs1577917 0.538 rs7755996 chr6:86423720 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.35 5.25 0.31 3.19e-7 Response to antipsychotic treatment; CESC cis rs7216064 1.000 rs1976053 chr17:65833002 C/G cg12091567 chr17:66097778 LOC651250 -0.81 -9.7 -0.51 3.18e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs722599 0.748 rs17093914 chr14:75363641 A/G cg11812906 chr14:75593930 NEK9 0.48 5.79 0.33 2.02e-8 IgG glycosylation; CESC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.53 7.89 0.44 7.99e-14 Bipolar disorder; CESC cis rs7829975 0.774 rs1039915 chr8:8679614 T/C cg06636001 chr8:8085503 FLJ10661 0.46 5.98 0.34 7.1e-9 Mood instability; CESC cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03399598 chr4:174091002 GALNT7 -0.46 -6.89 -0.39 4.15e-11 Gambling; CESC cis rs7249142 0.549 rs3787040 chr19:19297292 A/G cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.3 5.37 0.31 1.75e-7 IgG glycosylation; CESC cis rs7618501 0.521 rs11130222 chr3:49901060 A/T cg24308560 chr3:49941425 MST1R -0.64 -8.99 -0.48 4.68e-17 Intelligence (multi-trait analysis); CESC cis rs7208859 0.623 rs57486336 chr17:29085731 G/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9581857 0.685 rs9319370 chr13:28042493 G/T cg01674679 chr13:27998804 GTF3A -0.69 -5.52 -0.32 8.1e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7100689 0.646 rs7081889 chr10:82165427 C/A cg00277334 chr10:82204260 NA -0.46 -6.25 -0.36 1.67e-9 Post bronchodilator FEV1; CESC cis rs7586673 1.000 rs7586673 chr2:161923520 C/A cg08807892 chr2:162101083 NA 0.46 6.24 0.36 1.68e-9 Intelligence (multi-trait analysis); CESC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg19318889 chr4:1322082 MAEA -0.5 -6.46 -0.37 5.05e-10 Obesity-related traits; CESC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg04025307 chr7:1156635 C7orf50 0.47 6.51 0.37 3.75e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9612 1.000 rs28446957 chr19:44246600 T/A cg08581076 chr19:44259116 C19orf61 0.58 6.62 0.38 1.95e-10 Exhaled nitric oxide output; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17502267 chr15:59981239 BNIP2 -0.56 -7.35 -0.41 2.5e-12 Gut microbiota (bacterial taxa); CESC cis rs7208859 0.623 rs73271842 chr17:29137155 T/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12476592 0.602 rs262479 chr2:63872479 C/T cg17519650 chr2:63277830 OTX1 -0.44 -5.05 -0.3 8.32e-7 Childhood ear infection; CESC cis rs6493487 0.512 rs28430533 chr15:51256012 T/C cg02338191 chr15:51200825 AP4E1 0.63 5.84 0.34 1.49e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.46 -0.54 1.15e-21 Alzheimer's disease; CESC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg17971929 chr21:40555470 PSMG1 0.9 11.81 0.59 3.7e-26 Cognitive function; CESC cis rs854765 0.583 rs7214002 chr17:17852104 G/C cg16928487 chr17:17741425 SREBF1 -0.52 -8.66 -0.47 4.86e-16 Total body bone mineral density; CESC cis rs1005277 0.529 rs1780125 chr10:38531376 A/G cg25427524 chr10:38739819 LOC399744 -0.72 -10.76 -0.55 1.2e-22 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20972342 chr5:235327 SDHA -0.59 -7.09 -0.4 1.21e-11 Gut microbiome composition (summer); CESC cis rs12618769 0.597 rs17032120 chr2:99082938 A/G cg10123293 chr2:99228465 UNC50 -0.39 -5.17 -0.3 4.71e-7 Bipolar disorder; CESC cis rs4975616 0.836 rs13178866 chr5:1323212 C/T cg06550200 chr5:1325588 CLPTM1L -0.71 -11.17 -0.57 5.29e-24 Lung cancer; CESC cis rs7927771 0.832 rs10838698 chr11:47385923 G/A cg18512352 chr11:47633146 NA 0.53 7.51 0.42 8.89e-13 Subjective well-being; CESC cis rs6991838 0.584 rs10957361 chr8:66531861 C/G cg13398993 chr8:66546079 ARMC1 0.46 5.65 0.33 4.19e-8 Intelligence (multi-trait analysis); CESC cis rs2191566 1.000 rs7256908 chr19:44528898 C/T cg20607764 chr19:44506953 ZNF230 -0.63 -8.19 -0.45 1.15e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs2119480 0.559 rs381835 chr13:111300957 A/T cg16216153 chr13:111290848 CARKD -0.36 -5.46 -0.32 1.1e-7 Diastolic blood pressure; CESC cis rs2404602 0.692 rs58889902 chr15:77173070 A/C cg26408565 chr15:76604113 ETFA -0.39 -5.68 -0.33 3.6e-8 Blood metabolite levels; CESC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg10150615 chr22:24372951 LOC391322 -0.58 -8.04 -0.44 2.96e-14 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7264396 0.563 rs2425131 chr20:34337074 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.74 0.38 9.75e-11 Total cholesterol levels; CESC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg00750074 chr16:89608354 SPG7 -0.44 -6.36 -0.36 8.85e-10 Multiple myeloma (IgH translocation); CESC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg22800045 chr5:56110881 MAP3K1 0.59 7.6 0.42 5.08e-13 Coronary artery disease; CESC cis rs9911578 1.000 rs9901114 chr17:56575208 G/A cg05425664 chr17:57184151 TRIM37 0.48 6.63 0.38 1.92e-10 Intelligence (multi-trait analysis); CESC cis rs916888 0.821 rs199507 chr17:44858855 A/G cg15921436 chr17:44337874 NA -0.7 -7.95 -0.44 5.35e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs897080 0.516 rs1067361 chr2:44661217 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.76 0.33 2.3e-8 Height; CESC cis rs7071206 0.853 rs66786803 chr10:79429941 A/G cg23888215 chr10:79422304 NA -0.53 -5.96 -0.34 8.03e-9 Bone mineral density; CESC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg24879335 chr3:133465180 TF 0.33 5.33 0.31 2.07e-7 Iron status biomarkers; CESC cis rs861020 0.630 rs628300 chr1:209998298 C/T cg05527609 chr1:210001259 C1orf107 0.84 11.26 0.57 2.8e-24 Orofacial clefts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20853569 chr17:79247697 SLC38A10 -0.56 -6.06 -0.35 4.58e-9 Gut microbiome composition (summer); CESC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg05275752 chr2:38892887 GALM -0.49 -6.77 -0.38 8.5e-11 5-HTT brain serotonin transporter levels; CESC cis rs6541297 0.703 rs638116 chr1:230310740 C/T cg20703242 chr1:230279135 GALNT2 -0.43 -5.56 -0.32 6.46e-8 Coronary artery disease; CESC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg07414097 chr2:232646663 PDE6D 0.47 6.09 0.35 4.06e-9 Neuroticism; CESC cis rs6964587 1.000 rs1859114 chr7:91682848 T/C cg17063962 chr7:91808500 NA 0.58 8.03 0.44 3.17e-14 Breast cancer; CESC cis rs1707322 1.000 rs1768817 chr1:46514534 C/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.65 -0.33 4.08e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs889312 0.500 rs832552 chr5:56113850 A/C cg14703610 chr5:56206110 C5orf35 -0.45 -6.34 -0.36 1.01e-9 Breast cancer;Breast cancer (early onset); CESC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg21724239 chr8:58056113 NA 0.56 5.04 0.3 8.84e-7 Developmental language disorder (linguistic errors); CESC cis rs644799 0.965 rs545342 chr11:95545369 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs71403859 0.502 rs7195767 chr16:71464943 A/G cg08717414 chr16:71523259 ZNF19 -0.86 -8.58 -0.47 7.96e-16 Post bronchodilator FEV1; CESC cis rs10504073 0.647 rs6997703 chr8:49998364 T/C cg00325661 chr8:49890786 NA 0.58 8.52 0.46 1.19e-15 Blood metabolite ratios; CESC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg05368731 chr17:41323189 NBR1 0.8 11.32 0.57 1.66e-24 Menopause (age at onset); CESC trans rs3780486 0.846 rs7865745 chr9:33140976 A/G cg04842962 chr6:43655489 MRPS18A -1.0 -19.5 -0.77 3.8e-53 IgG glycosylation; CESC cis rs3008870 1.000 rs2985811 chr1:67377722 G/T cg08660285 chr1:67390436 MIER1;WDR78 1.05 14.57 0.67 9.8e-36 Lymphocyte percentage of white cells; CESC cis rs7917772 0.536 rs11191361 chr10:104411958 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.58 7.1 0.4 1.16e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg20243544 chr17:37824526 PNMT 0.51 6.5 0.37 3.97e-10 Glomerular filtration rate (creatinine); CESC cis rs208515 0.525 rs12215007 chr6:66671008 C/T cg07460842 chr6:66804631 NA -0.87 -11.02 -0.56 1.7e-23 Exhaled nitric oxide levels; CESC cis rs35306767 0.904 rs35667562 chr10:950630 G/A cg10556349 chr10:835070 NA 0.72 6.05 0.35 4.94e-9 Eosinophil percentage of granulocytes; CESC cis rs8014204 0.604 rs11159109 chr14:75389074 G/A cg11812906 chr14:75593930 NEK9 0.54 6.68 0.38 1.44e-10 Caffeine consumption; CESC cis rs6964587 1.000 rs7806184 chr7:91601978 A/G cg17063962 chr7:91808500 NA 0.57 7.82 0.43 1.22e-13 Breast cancer; CESC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg04414720 chr1:150670196 GOLPH3L 0.57 7.44 0.42 1.43e-12 Melanoma; CESC cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg05890377 chr2:74357713 NA 0.76 10.21 0.53 7.42e-21 Gestational age at birth (maternal effect); CESC cis rs2717559 0.542 rs2717590 chr8:143900712 A/G cg17252645 chr8:143867129 LY6D -0.32 -5.23 -0.31 3.44e-7 Urinary tract infection frequency; CESC cis rs8062405 0.755 rs12445823 chr16:28588049 A/C cg07382826 chr16:28625726 SULT1A1 0.4 6.52 0.37 3.49e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs72681920 0.881 rs12504321 chr4:100202705 G/T cg22948791 chr15:71404101 CT62 -0.54 -6.14 -0.35 2.96e-9 Alcohol dependence; CESC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg18402987 chr7:1209562 NA 0.72 7.1 0.4 1.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 -0.43 -5.41 -0.32 1.39e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg17143192 chr8:8559678 CLDN23 0.71 8.17 0.45 1.27e-14 Obesity-related traits; CESC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg23172400 chr8:95962367 TP53INP1 -0.33 -6.07 -0.35 4.39e-9 Type 2 diabetes; CESC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg18252515 chr7:66147081 NA 0.39 5.18 0.3 4.4e-7 Aortic root size; CESC cis rs4662945 0.603 rs2406981 chr2:130305487 A/G cg05903289 chr2:130345205 NA -0.43 -6.39 -0.37 7.5e-10 Response to cytidine analogues (gemcitabine); CESC cis rs71403859 0.570 rs77809998 chr16:71430687 C/T cg08717414 chr16:71523259 ZNF19 -1.1 -8.98 -0.48 5.21e-17 Post bronchodilator FEV1; CESC cis rs9902453 0.542 rs3809789 chr17:27955761 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 6.4 0.37 6.97e-10 Coffee consumption (cups per day); CESC cis rs589448 0.867 rs623853 chr12:69753830 G/A cg20891283 chr12:69753455 YEATS4 1.0 17.27 0.73 2.72e-45 Cerebrospinal fluid biomarker levels; CESC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17608500 chr1:154955711 FLAD1 0.46 6.25 0.36 1.67e-9 Systemic lupus erythematosus; CESC cis rs11711311 1.000 rs62268168 chr3:113489447 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.71 10.02 0.52 3.12e-20 IgG glycosylation; CESC cis rs78456975 1.000 rs13416881 chr2:1554808 G/A cg26248373 chr2:1572462 NA -0.58 -5.22 -0.31 3.68e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs2404602 0.647 rs2404604 chr15:76991105 A/G cg23625390 chr15:77176239 SCAPER -0.4 -5.21 -0.3 3.85e-7 Blood metabolite levels; CESC cis rs2072499 0.833 rs2842870 chr1:156200671 T/C cg25208724 chr1:156163844 SLC25A44 0.84 13.54 0.64 4.32e-32 Testicular germ cell tumor; CESC cis rs12042052 0.590 rs16858252 chr1:232949224 A/C cg06935979 chr1:232941706 KIAA1383 0.71 5.9 0.34 1.09e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 6.47 0.37 4.75e-10 Bipolar disorder; CESC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg11644478 chr21:40555479 PSMG1 1.05 17.05 0.72 1.61e-44 Cognitive function; CESC cis rs34172651 0.917 rs11074654 chr16:24813743 A/G cg06028605 chr16:24865363 SLC5A11 0.34 5.32 0.31 2.24e-7 Intelligence (multi-trait analysis); CESC cis rs34779708 0.966 rs12257770 chr10:35517234 A/G cg04310649 chr10:35416472 CREM -0.51 -6.11 -0.35 3.6e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs4664308 0.870 rs2198918 chr2:161015052 C/T cg03641300 chr2:160917029 PLA2R1 -0.62 -9.13 -0.49 1.82e-17 Idiopathic membranous nephropathy; CESC cis rs7829975 0.774 rs13259216 chr8:8673601 A/C cg17143192 chr8:8559678 CLDN23 0.42 5.18 0.3 4.5e-7 Mood instability; CESC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg17376030 chr22:41985996 PMM1 -0.75 -8.08 -0.44 2.34e-14 Vitiligo; CESC cis rs1712517 0.525 rs2271751 chr10:105175131 A/G cg04362960 chr10:104952993 NT5C2 -0.46 -5.53 -0.32 7.83e-8 Migraine; CESC cis rs4332037 0.624 rs56256289 chr7:1892529 C/T cg23422044 chr7:1970798 MAD1L1 -0.49 -5.36 -0.31 1.82e-7 Bipolar disorder; CESC cis rs7845219 0.544 rs9643351 chr8:95917290 C/T cg23172400 chr8:95962367 TP53INP1 -0.38 -6.92 -0.39 3.35e-11 Type 2 diabetes; CESC cis rs11630290 0.736 rs7174738 chr15:64144813 A/T cg12036633 chr15:63758958 NA -0.57 -6.1 -0.35 3.65e-9 Iris characteristics; CESC cis rs9467711 0.659 rs66941101 chr6:26530376 C/T cg14345882 chr6:26364793 BTN3A2 0.61 5.24 0.31 3.27e-7 Autism spectrum disorder or schizophrenia; CESC cis rs12136530 0.509 rs2268812 chr1:19666928 A/G cg01832549 chr1:19774989 CAPZB -0.39 -5.34 -0.31 2.05e-7 Lead levels in blood; CESC cis rs250677 0.522 rs6872172 chr5:148359529 G/C cg18129178 chr5:148520854 ABLIM3 0.47 5.16 0.3 4.93e-7 Breast cancer; CESC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg22143856 chr6:28129313 ZNF389 0.42 5.24 0.31 3.31e-7 Parkinson's disease; CESC cis rs734999 0.967 rs4486391 chr1:2513055 A/T cg20673091 chr1:2541236 MMEL1 0.31 5.1 0.3 6.6e-7 Ulcerative colitis; CESC cis rs748404 0.697 rs546170 chr15:43564849 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.5 7.7 0.43 2.73e-13 Lung cancer; CESC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg08499158 chr17:42289980 UBTF -0.56 -7.32 -0.41 2.94e-12 Total body bone mineral density; CESC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg05368731 chr17:41323189 NBR1 0.56 7.62 0.42 4.53e-13 Menopause (age at onset); CESC cis rs2228479 0.557 rs11648881 chr16:89862434 T/C cg14709524 chr16:89940631 TCF25 0.93 6.92 0.39 3.35e-11 Skin colour saturation; CESC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg00684032 chr4:1343700 KIAA1530 0.38 5.69 0.33 3.43e-8 Longevity; CESC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg15352829 chr14:105391018 PLD4 -0.6 -10.53 -0.54 6.87e-22 Rheumatoid arthritis; CESC cis rs6912958 0.781 rs6916732 chr6:88259225 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.55 -0.37 3.03e-10 Monocyte percentage of white cells; CESC cis rs7098414 0.530 rs10749572 chr10:82136664 G/T cg00277334 chr10:82204260 NA -0.52 -7.67 -0.43 3.38e-13 Post bronchodilator FEV1; CESC cis rs1775715 0.835 rs1419169 chr10:32257204 C/G cg04359828 chr10:32216031 ARHGAP12 0.35 5.13 0.3 5.49e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg01083584 chr19:14629193 DNAJB1 0.43 6.06 0.35 4.7e-9 Breast cancer;Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08944080 chr1:156675950 CRABP2 0.6 6.59 0.38 2.35e-10 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs17226666 chr16:89835401 G/A cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg11764359 chr7:65958608 NA 0.82 9.56 0.51 8.23e-19 Aortic root size; CESC cis rs3026101 0.624 rs60691290 chr17:5318503 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.4 5.22 0.31 3.64e-7 Body mass index; CESC cis rs4664304 0.789 rs7595388 chr2:160756345 G/A cg03641300 chr2:160917029 PLA2R1 -0.43 -5.82 -0.34 1.7e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg22823121 chr1:150693482 HORMAD1 0.47 6.95 0.39 2.77e-11 Tonsillectomy; CESC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 13.44 0.64 9.78e-32 Alzheimer's disease; CESC trans rs4942242 0.512 rs9533551 chr13:44187120 G/C cg19169023 chr15:41853346 TYRO3 -0.67 -8.34 -0.46 4.11e-15 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3753275 0.690 rs301809 chr1:8519070 C/T cg00120948 chr1:8484417 RERE -0.41 -5.08 -0.3 7.08e-7 Educational attainment; CESC cis rs7605827 0.897 rs7564514 chr2:15654808 G/A cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.7e-10 Educational attainment (years of education); CESC cis rs72634258 0.786 rs4268374 chr1:8174083 G/T cg00042356 chr1:8021962 PARK7 -0.47 -5.21 -0.3 3.76e-7 Inflammatory bowel disease; CESC cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg13628971 chr7:2884303 GNA12 0.43 5.74 0.33 2.58e-8 Height; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21482489 chr5:121414366 LOX -0.48 -6.62 -0.38 1.99e-10 Asthma; CESC cis rs3126085 0.935 rs2152862 chr1:152259742 T/C cg03465714 chr1:152285911 FLG 0.45 5.54 0.32 7.12e-8 Atopic dermatitis; CESC cis rs2228479 0.850 rs1800344 chr16:89816367 T/G cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs12995849 0.905 rs12712218 chr2:106451751 G/T cg16077055 chr2:106428750 NCK2 0.39 6.23 0.36 1.85e-9 Addiction; CESC cis rs60154123 0.730 rs652241 chr1:210465029 A/T cg22029157 chr1:209979665 IRF6 0.48 5.88 0.34 1.21e-8 Coronary artery disease; CESC trans rs7089973 0.549 rs7094440 chr10:116745408 T/C cg17463145 chr7:79084011 MAGI2 0.32 6.36 0.36 8.92e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4474465 0.688 rs4457782 chr11:78284733 A/G cg27205649 chr11:78285834 NARS2 0.39 5.09 0.3 6.7e-7 Alzheimer's disease (survival time); CESC cis rs752010 0.574 rs6671999 chr1:42120416 G/A cg06885757 chr1:42089581 HIVEP3 0.47 7.64 0.43 3.89e-13 Lupus nephritis in systemic lupus erythematosus; CESC trans rs561341 0.941 rs112569713 chr17:30271738 C/T cg20587970 chr11:113659929 NA -1.12 -14.14 -0.66 3.28e-34 Hip circumference adjusted for BMI; CESC cis rs9911578 1.000 rs9898626 chr17:56698219 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.27 0.31 2.87e-7 Intelligence (multi-trait analysis); CESC cis rs12142240 0.698 rs17357635 chr1:46808668 G/A cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC cis rs826838 0.967 rs980572 chr12:39127673 A/C cg26384229 chr12:38710491 ALG10B 0.63 9.67 0.51 3.75e-19 Heart rate; CESC cis rs4843747 0.749 rs12102841 chr16:88072574 C/G cg06915872 chr16:87998081 BANP -0.48 -6.07 -0.35 4.33e-9 Menopause (age at onset); CESC cis rs4891159 0.790 rs4891018 chr18:74127082 A/T cg24786174 chr18:74118243 ZNF516 -0.74 -11.98 -0.59 9.92e-27 Longevity; CESC cis rs9348729 1 rs9348729 chr6:26664268 T/C cg14345882 chr6:26364793 BTN3A2 0.41 5.25 0.31 3.16e-7 Intelligence (multi-trait analysis); CESC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg10800226 chr5:1850261 NA 0.35 5.65 0.33 4.18e-8 Cardiovascular disease risk factors; CESC cis rs17039065 0.920 rs17039103 chr4:109434995 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.67 6.15 0.35 2.81e-9 Gut microbiome composition (summer); CESC cis rs1499972 0.941 rs1093464 chr3:117726256 C/T cg07612923 chr3:117604196 NA -0.8 -5.97 -0.34 7.5e-9 Schizophrenia; CESC cis rs910316 0.712 rs175015 chr14:75457075 A/C cg08847533 chr14:75593920 NEK9 -0.87 -14.67 -0.67 4.68e-36 Height; CESC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg04553112 chr3:125709451 NA -0.52 -5.47 -0.32 1.03e-7 Blood pressure (smoking interaction); CESC cis rs10949834 0.878 rs2527839 chr7:73510891 G/C cg07137043 chr7:73588983 EIF4H -0.65 -5.65 -0.33 4.1e-8 Verbal memory performance (residualized delayed recall change); CESC cis rs1008375 1.000 rs2058337 chr4:17678649 C/T cg16339924 chr4:17578868 LAP3 0.47 6.03 0.35 5.4e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25955816 chr1:228612876 HIST3H3 -0.69 -7.64 -0.42 3.86e-13 Gut microbiome composition (summer); CESC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg07507251 chr3:52567010 NT5DC2 0.45 8.24 0.45 7.76e-15 Electroencephalogram traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17979991 chr7:43769177 C7orf44 -0.42 -6.55 -0.37 3.05e-10 Gambling; CESC cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.21e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4909189 0.957 rs71547529 chr7:158135469 G/T cg24154853 chr7:158122151 PTPRN2 0.48 6.22 0.36 1.94e-9 Response to amphetamines; CESC cis rs9814567 1.000 rs7432268 chr3:134242051 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.37 -0.36 8.41e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs4319547 0.695 rs10846699 chr12:122853073 A/G cg05707623 chr12:122985044 ZCCHC8 0.55 6.43 0.37 5.88e-10 Body mass index; CESC cis rs1062177 0.756 rs2964587 chr5:151119972 C/T cg00977110 chr5:151150581 G3BP1 -0.62 -6.36 -0.36 8.62e-10 Preschool internalizing problems; CESC cis rs3845702 0.736 rs12465592 chr2:180862654 C/G cg01881094 chr2:180872142 CWC22 1.08 9.4 0.5 2.75e-18 Schizophrenia; CESC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg20887711 chr4:1340912 KIAA1530 0.55 7.84 0.43 1.08e-13 Longevity; CESC cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg02551604 chr5:131831745 NA 0.39 5.54 0.32 7.14e-8 Asthma (sex interaction); CESC cis rs6024905 0.551 rs2425364 chr20:36969340 G/T cg07053727 chr20:36965646 BPI 0.5 7.65 0.43 3.68e-13 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09581281 chr1:15853227 DNAJC16 0.49 6.31 0.36 1.13e-9 Gut microbiota (bacterial taxa); CESC cis rs1032355 0.722 rs13139650 chr4:100513580 G/C cg05468953 chr4:100565104 NA 0.34 5.11 0.3 6.23e-7 Celiac disease; CESC trans rs9467711 0.790 rs13195401 chr6:26463574 G/T cg01620082 chr3:125678407 NA -0.79 -6.2 -0.36 2.13e-9 Autism spectrum disorder or schizophrenia; CESC cis rs816535 1 rs816535 chr20:26255996 C/T cg04150495 chr20:26190328 MIR663 0.3 5.73 0.33 2.67e-8 Parkinson disease and lewy body pathology; CESC cis rs2718058 0.601 rs2709104 chr7:37762810 A/G cg15028436 chr7:37888078 TXNDC3 -0.44 -6.24 -0.36 1.69e-9 Alzheimer's disease (late onset); CESC cis rs6580649 0.941 rs57380031 chr12:48452237 C/T cg05342945 chr12:48394962 COL2A1 0.5 5.85 0.34 1.47e-8 Lung cancer; CESC cis rs854765 0.547 rs2955385 chr17:17939247 C/T cg04398451 chr17:18023971 MYO15A -0.72 -10.57 -0.54 5.17e-22 Total body bone mineral density; CESC cis rs6467136 0.765 rs17715255 chr7:127195850 C/T cg25922125 chr7:127225783 GCC1 -0.37 -5.11 -0.3 6.03e-7 Type 2 diabetes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14778137 chr11:66336132 CTSF -0.4 -6.16 -0.35 2.65e-9 Gambling; CESC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg11890956 chr21:40555474 PSMG1 0.94 15.36 0.69 1.56e-38 Cognitive function; CESC cis rs6598163 0.517 rs11246827 chr12:132296423 G/A cg22244940 chr12:132335942 MMP17 0.53 7.22 0.41 5.5e-12 Migraine; CESC cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg03213289 chr20:61660250 NA 0.39 6.1 0.35 3.69e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9389248 0.690 rs1028314 chr6:135255710 A/C cg22676075 chr6:135203613 NA -0.6 -8.48 -0.46 1.57e-15 High light scatter reticulocyte percentage of red cells; CESC cis rs7927771 0.965 rs17788930 chr11:47752775 A/G cg18512352 chr11:47633146 NA -0.6 -9.45 -0.5 1.91e-18 Subjective well-being; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23260255 chr3:187871479 LPP -0.45 -6.54 -0.37 3.16e-10 Gambling; CESC cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg10556349 chr10:835070 NA 0.59 5.59 0.32 5.54e-8 Eosinophil percentage of granulocytes; CESC trans rs3925158 0.510 rs34886276 chr3:38291717 A/C cg23247845 chr10:3679085 NA 0.66 6.06 0.35 4.74e-9 Gut microbiota (bacterial taxa); CESC cis rs1691799 0.806 rs1168319 chr12:66744857 T/A cg16791601 chr12:66731901 HELB -0.79 -14.34 -0.66 6.63e-35 White blood cell count (basophil); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04542817 chr3:15116352 ZFYVE20 -0.56 -6.64 -0.38 1.81e-10 Gut microbiome composition (summer); CESC cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg20891283 chr12:69753455 YEATS4 -0.6 -8.38 -0.46 3.23e-15 Blood protein levels; CESC cis rs10779751 0.734 rs1130683 chr1:11132217 G/A cg08854313 chr1:11322531 MTOR 0.76 10.24 0.53 5.91e-21 Body mass index; CESC cis rs4727027 0.645 rs12704072 chr7:148904888 G/A cg23583168 chr7:148888333 NA -0.93 -16.96 -0.72 3.33e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2070677 0.935 rs12245634 chr10:135420002 A/G cg20169779 chr10:135381914 SYCE1 -0.73 -9.56 -0.51 8.51e-19 Gout; CESC cis rs2836633 0.929 rs4514962 chr21:40041753 C/T cg12884169 chr21:40033163 ERG 0.39 6.21 0.36 2.06e-9 Coronary artery disease; CESC cis rs17376456 0.877 rs12374488 chr5:93481407 A/G cg25358565 chr5:93447407 FAM172A 1.17 10.96 0.56 2.63e-23 Diabetic retinopathy; CESC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg18225595 chr11:63971243 STIP1 0.52 5.14 0.3 5.26e-7 Mean platelet volume; CESC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg11987759 chr7:65425863 GUSB -0.47 -6.37 -0.36 8.52e-10 Calcium levels; CESC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.35 0.31 1.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs853679 1.000 rs1679732 chr6:28221264 G/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL -0.8 -8.47 -0.46 1.76e-15 Depression; CESC cis rs752010 0.714 rs6664708 chr1:42083070 G/A cg12614395 chr1:42085415 HIVEP3 0.29 5.04 0.3 8.66e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg03609598 chr5:56110824 MAP3K1 -0.52 -5.45 -0.32 1.18e-7 Initial pursuit acceleration; CESC cis rs7208859 0.673 rs75142521 chr17:29240537 G/A cg19761014 chr17:28927070 LRRC37B2 0.62 5.22 0.31 3.55e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.81e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6594499 0.872 rs10051830 chr5:110452845 G/A cg04022379 chr5:110408740 TSLP 0.33 5.7 0.33 3.24e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7100689 0.784 rs10749578 chr10:82139115 A/G cg00277334 chr10:82204260 NA 0.59 7.5 0.42 9.45e-13 Post bronchodilator FEV1; CESC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg24633833 chr3:10029261 TMEM111 0.45 5.17 0.3 4.55e-7 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11437374 chr5:169010780 CCDC99 0.59 6.94 0.39 3.07e-11 Gut microbiome composition (summer); CESC cis rs1506636 1.000 rs2429617 chr7:123418027 A/G cg03229431 chr7:123269106 ASB15 0.49 6.59 0.38 2.41e-10 Plateletcrit;Platelet count; CESC cis rs7833986 0.501 rs72653978 chr8:57018393 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.54 0.42 7.58e-13 Height; CESC cis rs6424115 0.830 rs2502992 chr1:24201919 T/C cg10978503 chr1:24200527 CNR2 0.34 6.62 0.38 2.01e-10 Immature fraction of reticulocytes; CESC cis rs1008375 0.932 rs6845288 chr4:17665498 A/T cg02297831 chr4:17616191 MED28 -0.53 -6.06 -0.35 4.65e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg19193384 chr17:30244184 NA -0.46 -5.19 -0.3 4.15e-7 Hip circumference adjusted for BMI; CESC cis rs4629710 0.545 rs3777477 chr6:131534374 T/C cg12606694 chr6:131520996 AKAP7 0.38 5.05 0.3 8.18e-7 Multiple myeloma (IgH translocation); CESC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg06877462 chr1:205807181 PM20D1 0.38 5.41 0.32 1.43e-7 Menarche (age at onset); CESC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg26769984 chr7:1090371 C7orf50 0.54 6.25 0.36 1.65e-9 Bronchopulmonary dysplasia; CESC cis rs4604732 0.631 rs12031694 chr1:247623653 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.51 6.61 0.38 2.14e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2276314 0.857 rs9960670 chr18:33577712 A/G cg05985134 chr18:33552581 C18orf21 0.61 7.03 0.4 1.72e-11 Endometriosis;Drug-induced torsades de pointes; CESC cis rs2760061 0.598 rs849904 chr1:228137145 G/C cg02753203 chr1:228287806 NA -0.5 -7.22 -0.41 5.54e-12 Diastolic blood pressure; CESC cis rs2832191 0.671 rs2409332 chr21:30512779 G/A cg24692254 chr21:30365293 RNF160 -0.6 -7.62 -0.42 4.44e-13 Dental caries; CESC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg09365446 chr1:150670422 GOLPH3L 0.4 5.27 0.31 2.86e-7 Melanoma; CESC cis rs910316 1.000 rs175426 chr14:75624134 C/T cg11812906 chr14:75593930 NEK9 -0.88 -15.31 -0.68 2.55e-38 Height; CESC cis rs2228479 0.850 rs11639788 chr16:89807543 G/A cg00800038 chr16:89945340 TCF25 -0.87 -7.27 -0.41 4.07e-12 Skin colour saturation; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13325346 chr17:37353483 CACNB1 0.44 6.33 0.36 1.03e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1256061 0.603 rs960069 chr14:64745002 C/T cg23250157 chr14:64679961 SYNE2 0.53 7.49 0.42 1.03e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.23 0.53 6.6e-21 Prudent dietary pattern; CESC cis rs6539267 0.741 rs10861572 chr12:106688576 A/G cg00173435 chr12:106696525 TCP11L2 -0.67 -7.78 -0.43 1.6e-13 Tourette syndrome; CESC cis rs453301 0.571 rs2929305 chr8:9085217 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -6.85 -0.39 5.07e-11 Joint mobility (Beighton score); CESC cis rs7555523 0.779 rs2790049 chr1:165743523 A/G cg24409356 chr1:165738333 TMCO1 1.03 8.91 0.48 8.27e-17 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.71 6.1 0.35 3.74e-9 Platelet count; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26468274 chr6:43544000 XPO5;POLH -0.49 -6.74 -0.38 1e-10 Fibrinogen levels; CESC cis rs8060686 0.641 rs2418737 chr16:68122726 T/C cg26727032 chr16:67993705 SLC12A4 -0.53 -6.32 -0.36 1.13e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg03709012 chr19:19516395 GATAD2A 0.96 14.1 0.65 4.66e-34 Tonsillectomy; CESC cis rs79057730 0.527 rs34519158 chr7:811114 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.91 7.84 0.43 1.1e-13 Initial pursuit acceleration; CESC cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg17366294 chr4:99064904 C4orf37 -0.6 -8.33 -0.46 4.42e-15 Colonoscopy-negative controls vs population controls; CESC trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg03929089 chr4:120376271 NA 0.77 11.55 0.58 2.9e-25 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23538755 chr19:2774549 SGTA 0.5 6.27 0.36 1.48e-9 Gut microbiome composition (summer); CESC cis rs1048238 0.506 rs7525608 chr1:16141901 A/G cg22431228 chr1:16359049 CLCNKA -0.35 -6.14 -0.35 2.97e-9 Systolic blood pressure; CESC cis rs131777 0.577 rs5770928 chr22:51029091 G/C cg00083937 chr22:51039805 MAPK8IP2 0.38 5.34 0.31 2.02e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7274811 0.711 rs657040 chr20:32001292 A/G cg21523528 chr20:32077966 CBFA2T2 -0.48 -5.6 -0.33 5.31e-8 Height; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18970754 chr14:74079533 NA -0.45 -6.41 -0.37 6.65e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1865760 0.532 rs1061482 chr6:26086699 G/T cg17691542 chr6:26056736 HIST1H1C 0.39 5.08 0.3 7.26e-7 Height; CESC cis rs7909074 1.000 rs4948925 chr10:45392455 C/T cg05187965 chr10:45406764 TMEM72 -0.35 -5.41 -0.32 1.38e-7 Mean corpuscular volume; CESC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg03934478 chr11:495069 RNH1 0.56 5.39 0.31 1.54e-7 Body mass index; CESC trans rs10411161 0.702 rs1433081 chr19:52390710 A/C cg22319618 chr22:45562946 NUP50 -0.75 -7.39 -0.41 1.94e-12 Breast cancer; CESC cis rs9929218 1.000 rs12921546 chr16:68780069 G/A cg02972257 chr16:68554789 NA 0.54 6.32 0.36 1.12e-9 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21638108 chr19:19431283 KIAA0892;SF4 0.57 6.96 0.39 2.74e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16072655 chr12:10086277 CLEC2A -0.58 -7.03 -0.4 1.71e-11 Gut microbiome composition (summer); CESC cis rs9303401 0.614 rs35308719 chr17:57163501 C/T cg25039879 chr17:56429692 SUPT4H1 0.5 5.28 0.31 2.75e-7 Cognitive test performance; CESC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg23708337 chr7:1209742 NA 0.54 5.25 0.31 3.13e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 5.93 0.34 9.54e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9733 0.519 rs1134067 chr1:150721175 G/T cg17724175 chr1:150552817 MCL1 0.46 7.09 0.4 1.18e-11 Tonsillectomy; CESC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.51e-24 Menopause (age at onset); CESC cis rs7918232 0.943 rs6482593 chr10:27371437 A/G cg14240646 chr10:27532245 ACBD5 -0.69 -6.39 -0.37 7.29e-10 Breast cancer; CESC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg04267008 chr7:1944627 MAD1L1 -0.58 -7.01 -0.4 1.99e-11 Bipolar disorder and schizophrenia; CESC cis rs79057730 0.599 rs79272827 chr7:807015 C/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.92 7.89 0.44 7.75e-14 Initial pursuit acceleration; CESC cis rs7520050 0.966 rs6700597 chr1:46284246 G/A cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.38e-7 Red blood cell count;Reticulocyte count; CESC cis rs66573146 1.000 rs28729690 chr4:6962061 C/T cg00086871 chr4:6988644 TBC1D14 1.09 6.61 0.38 2.14e-10 Granulocyte percentage of myeloid white cells; CESC cis rs763121 0.785 rs5750646 chr22:39013830 T/C cg21395723 chr22:39101663 GTPBP1 0.52 6.92 0.39 3.42e-11 Menopause (age at onset); CESC cis rs733592 0.504 rs2261608 chr12:48721634 A/T cg24011408 chr12:48396354 COL2A1 0.44 6.86 0.39 4.82e-11 Plateletcrit; CESC trans rs35110281 0.720 rs162374 chr21:44927089 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.54 -7.3 -0.41 3.43e-12 Mean corpuscular volume; CESC cis rs9457247 0.934 rs2345571 chr6:167403400 T/G cg25258033 chr6:167368657 RNASET2 0.39 5.92 0.34 9.82e-9 Crohn's disease; CESC cis rs959260 0.925 rs9901434 chr17:73388770 A/G cg20590849 chr17:73267439 MIF4GD -0.57 -6.41 -0.37 6.55e-10 Systemic lupus erythematosus; CESC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg27170947 chr2:26402098 FAM59B -0.87 -9.89 -0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.65e-39 Menopause (age at onset); CESC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg16928487 chr17:17741425 SREBF1 -0.51 -8.5 -0.46 1.39e-15 Total body bone mineral density; CESC cis rs10791097 0.694 rs11222370 chr11:130744767 T/G cg12179176 chr11:130786555 SNX19 0.64 9.86 0.52 9.69e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg16325326 chr1:53192061 ZYG11B 0.65 9.89 0.52 7.87e-20 Monocyte count; CESC trans rs7246760 0.867 rs12461215 chr19:9782461 G/A cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg07092213 chr7:1199455 ZFAND2A -0.42 -5.51 -0.32 8.44e-8 Longevity;Endometriosis; CESC cis rs1692580 0.870 rs590367 chr1:2162944 C/T cg24578937 chr1:2090814 PRKCZ 0.33 5.19 0.3 4.11e-7 Coronary artery disease; CESC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.67 -0.33 3.74e-8 Total body bone mineral density; CESC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 13.23 0.63 5.21e-31 Platelet count; CESC cis rs61931739 0.500 rs7965679 chr12:34542494 T/C cg06521331 chr12:34319734 NA -0.36 -5.03 -0.3 9.01e-7 Morning vs. evening chronotype; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19729279 chr5:133861951 PHF15 0.49 6.44 0.37 5.6e-10 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg03467027 chr4:99064603 C4orf37 0.48 5.9 0.34 1.11e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1215050 0.791 rs6813619 chr4:98830768 C/T cg05340658 chr4:99064831 C4orf37 -0.48 -6.31 -0.36 1.15e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs11608355 0.705 rs4766601 chr12:109890080 C/G cg05360138 chr12:110035743 NA 0.57 6.97 0.39 2.58e-11 Neuroticism; CESC cis rs8180040 0.783 rs11710121 chr3:47351501 T/G cg27129171 chr3:47204927 SETD2 -0.63 -9.12 -0.49 1.97e-17 Colorectal cancer; CESC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg07507251 chr3:52567010 NT5DC2 0.4 7.06 0.4 1.5e-11 Bipolar disorder; CESC cis rs7772486 0.875 rs2777479 chr6:146309178 C/A cg23711669 chr6:146136114 FBXO30 0.84 11.72 0.58 7.63e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.64 9.03 0.49 3.53e-17 Menarche (age at onset); CESC cis rs10927875 0.578 rs10927859 chr1:16141862 C/T cg18973939 chr1:16164122 FLJ37453 0.37 5.58 0.32 6e-8 Dilated cardiomyopathy; CESC cis rs7605827 0.930 rs11893303 chr2:15613715 G/A cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs2243480 1.000 rs57057549 chr7:65405738 A/G cg18252515 chr7:66147081 NA -1.23 -11.37 -0.57 1.14e-24 Diabetic kidney disease; CESC cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.33 0.31 2.11e-7 Personality dimensions; CESC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg24549020 chr5:56110836 MAP3K1 0.68 7.72 0.43 2.37e-13 Initial pursuit acceleration; CESC cis rs9467711 0.516 rs548987 chr6:25869371 C/G cg08501292 chr6:25962987 TRIM38 0.54 5.93 0.34 9.22e-9 Autism spectrum disorder or schizophrenia; CESC cis rs4925386 0.625 rs3810550 chr20:60912117 C/T cg12382846 chr20:60892121 LAMA5 0.41 6.43 0.37 6.06e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs920590 0.876 rs3907478 chr8:19657753 G/T cg17834443 chr8:19674713 INTS10 0.49 5.78 0.33 2.13e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg02353165 chr6:42928485 GNMT 0.84 13.21 0.63 6.05e-31 Alzheimer's disease in APOE e4+ carriers; CESC cis rs4664304 0.900 rs17231993 chr2:160741415 C/T cg03641300 chr2:160917029 PLA2R1 -0.47 -6.57 -0.37 2.64e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs10465746 0.935 rs11163878 chr1:84442654 G/A cg10977910 chr1:84465055 TTLL7 0.47 6.45 0.37 5.23e-10 Obesity-related traits; CESC cis rs6788895 1.000 rs16862842 chr3:150484844 A/G cg09723797 chr3:150481914 SIAH2 0.7 5.22 0.31 3.67e-7 Breast cancer; CESC cis rs36051895 0.623 rs62541541 chr9:5040817 G/C cg02405213 chr9:5042618 JAK2 -0.47 -5.56 -0.32 6.71e-8 Pediatric autoimmune diseases; CESC cis rs920590 0.684 rs57837509 chr8:19670088 A/G cg01411142 chr8:19674711 INTS10 0.56 6.24 0.36 1.77e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6499255 0.904 rs7187653 chr16:69562838 G/C cg15192750 chr16:69999425 NA 0.58 6.79 0.38 7.41e-11 IgE levels; CESC cis rs863345 0.967 rs10908664 chr1:158492629 G/A cg12129480 chr1:158549410 OR10X1 -0.31 -6.04 -0.35 5.08e-9 Pneumococcal bacteremia; CESC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg24549020 chr5:56110836 MAP3K1 0.68 7.76 0.43 1.85e-13 Initial pursuit acceleration; CESC cis rs9611565 0.546 rs739134 chr22:42089623 T/C cg03806693 chr22:41940476 POLR3H 1.04 12.31 0.6 7.65e-28 Vitiligo; CESC cis rs2635047 0.967 rs1355593 chr18:44746460 A/T cg19077165 chr18:44547161 KATNAL2 -0.43 -5.64 -0.33 4.42e-8 Educational attainment; CESC cis rs4523957 0.928 rs749240 chr17:2186100 A/G cg16513277 chr17:2031491 SMG6 0.56 6.93 0.39 3.24e-11 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11893307 0.507 rs1465305 chr2:191585392 C/G cg10560079 chr2:191398806 TMEM194B -0.45 -5.59 -0.32 5.55e-8 Mean platelet volume; CESC cis rs1707322 1.000 rs6687301 chr1:46382852 T/C cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.29e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs17508449 0.819 rs4839329 chr1:114135705 G/A cg23028848 chr11:57092561 TNKS1BP1 -0.79 -6.26 -0.36 1.54e-9 Leprosy; CESC cis rs6748734 0.894 rs4675869 chr2:241827696 A/G cg04034577 chr2:241836375 C2orf54 -0.47 -7.96 -0.44 5.1e-14 Urinary metabolites; CESC cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg00409905 chr10:38381863 ZNF37A -0.51 -6.8 -0.39 6.98e-11 Extrinsic epigenetic age acceleration; CESC cis rs12042938 1.000 rs823158 chr1:231782650 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.48 6.63 0.38 1.84e-10 Neuranatomic and neurocognitive phenotypes; CESC cis rs6460942 0.915 rs62447639 chr7:12486803 T/C cg02935154 chr7:12443704 VWDE -0.57 -5.94 -0.34 9.02e-9 Coronary artery disease; CESC cis rs9796 0.870 rs2306083 chr15:41347658 C/T cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.82 -0.39 6.24e-11 Menopause (age at onset); CESC cis rs473651 0.935 rs483166 chr2:239346641 C/T cg18131467 chr2:239335373 ASB1 -1.0 -20.86 -0.79 7.88e-58 Multiple system atrophy; CESC cis rs483180 0.532 rs561931 chr1:120254506 A/G cg19096424 chr1:120255104 PHGDH 0.5 6.29 0.36 1.31e-9 Macular telangiectasia type 2; CESC cis rs67478160 0.572 rs8015603 chr14:104293678 C/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.11 -0.4 1.1e-11 Schizophrenia; CESC cis rs2414059 0.548 rs3098177 chr15:50783777 A/G cg08437265 chr15:50716283 USP8 -0.51 -6.86 -0.39 4.87e-11 QT interval; CESC cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg08355456 chr11:67383691 NA 0.34 5.22 0.31 3.6e-7 Mean corpuscular volume; CESC cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg20573242 chr4:122745356 CCNA2 0.54 6.78 0.38 7.9e-11 Type 2 diabetes; CESC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg21226059 chr5:178986404 RUFY1 -0.51 -7.74 -0.43 2.11e-13 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05397629 chr11:3848986 RHOG -0.57 -6.69 -0.38 1.3100000000000001e-10 Gut microbiome composition (summer); CESC cis rs7116495 1.000 rs7949480 chr11:71697588 T/C cg26138937 chr11:71823887 C11orf51 -0.81 -6.63 -0.38 1.93e-10 Severe influenza A (H1N1) infection; CESC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg07701084 chr6:150067640 NUP43 0.43 5.81 0.34 1.77e-8 Lung cancer; CESC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg23978390 chr7:1156363 C7orf50 0.65 6.73 0.38 1.06e-10 Bronchopulmonary dysplasia; CESC cis rs7927771 0.524 rs7939420 chr11:47723938 A/G cg20307385 chr11:47447363 PSMC3 -0.58 -7.95 -0.44 5.41e-14 Subjective well-being; CESC cis rs644799 0.648 rs1255178 chr11:95471908 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.49 6.91 0.39 3.66e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg07414643 chr4:187882934 NA 0.52 7.4 0.41 1.83e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs28818218 chr4:98880575 A/C cg03467027 chr4:99064603 C4orf37 0.42 5.28 0.31 2.72e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12476592 0.516 rs4671503 chr2:63637091 A/T cg17519650 chr2:63277830 OTX1 -0.47 -5.19 -0.3 4.21e-7 Childhood ear infection; CESC cis rs1881797 0.872 rs12408686 chr1:247691141 C/T cg18198730 chr1:247681584 NA 0.63 8.15 0.45 1.42e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs79349575 0.783 rs4793996 chr17:47019597 T/C cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs2797160 1.000 rs1935773 chr6:125996475 A/G cg05901451 chr6:126070800 HEY2 -0.46 -6.72 -0.38 1.1e-10 Endometrial cancer; CESC cis rs67460515 0.892 rs4856756 chr3:160999414 G/A cg03342759 chr3:160939853 NMD3 -0.53 -7.52 -0.42 8.34e-13 Parkinson's disease; CESC cis rs11098499 0.909 rs7681978 chr4:120383775 T/C cg24375607 chr4:120327624 NA 0.45 5.52 0.32 8.05e-8 Corneal astigmatism; CESC cis rs11785693 0.817 rs62491199 chr8:4997878 G/A cg26367366 chr8:4980734 NA 0.81 7.68 0.43 3.05e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg06074448 chr4:187884817 NA 0.38 5.48 0.32 1e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs17376456 0.877 rs17083462 chr5:93462401 T/G cg25358565 chr5:93447407 FAM172A 1.15 11.75 0.59 5.96e-26 Diabetic retinopathy; CESC cis rs62344088 1.000 rs10065373 chr5:106819 C/T cg22857025 chr5:266934 NA -1.01 -5.45 -0.32 1.14e-7 Asthma (childhood onset); CESC cis rs9611565 0.580 rs5758449 chr22:42140160 C/T cg03806693 chr22:41940476 POLR3H 0.78 9.54 0.51 9.81e-19 Vitiligo; CESC cis rs7208859 0.623 rs8081299 chr17:29104296 G/A cg19761014 chr17:28927070 LRRC37B2 0.74 6.05 0.35 4.88e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6088590 0.523 rs6088536 chr20:33189106 T/C cg06115741 chr20:33292138 TP53INP2 0.53 6.69 0.38 1.3100000000000001e-10 Coronary artery disease; CESC cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg24879335 chr3:133465180 TF -0.43 -8.19 -0.45 1.14e-14 Iron status biomarkers (transferrin levels); CESC cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg27129171 chr3:47204927 SETD2 -0.67 -9.09 -0.49 2.38e-17 Colorectal cancer; CESC cis rs17039065 0.920 rs7672020 chr4:109436064 T/C cg16022748 chr4:109541635 LOC285456;RPL34 0.67 6.4 0.37 7.14e-10 Gut microbiome composition (summer); CESC cis rs8060686 0.920 rs3809630 chr16:67879400 G/A cg26727032 chr16:67993705 SLC12A4 -0.58 -6.26 -0.36 1.55e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg25767906 chr1:53392781 SCP2 -0.5 -7.06 -0.4 1.49e-11 Monocyte count; CESC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg10691866 chr7:65817282 TPST1 0.33 5.51 0.32 8.45e-8 Aortic root size; CESC cis rs1580019 0.885 rs1610141 chr7:32498435 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.89 12.7 0.62 3.54e-29 Cognitive ability; CESC cis rs73206853 0.563 rs4073472 chr12:111176494 A/G cg04375036 chr12:111181819 PPP1CC -0.64 -5.11 -0.3 6.21e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs796364 0.950 rs188146 chr2:200750444 C/T cg23649088 chr2:200775458 C2orf69 0.56 5.29 0.31 2.54e-7 Schizophrenia; CESC cis rs6942756 1.000 rs7778277 chr7:128978805 C/T cg02491457 chr7:128862824 NA -0.68 -9.24 -0.49 8.31e-18 White matter hyperintensity burden; CESC cis rs947211 0.948 rs1775143 chr1:205755550 C/T cg26354017 chr1:205819088 PM20D1 0.44 5.68 0.33 3.49e-8 Parkinson's disease; CESC cis rs2242073 0.627 rs13007922 chr2:209004186 G/A cg10392614 chr2:208977121 NA -0.37 -5.05 -0.3 8.4e-7 Attention deficit hyperactivity disorder; CESC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg23758822 chr17:41437982 NA 0.98 14.49 0.66 1.97e-35 Menopause (age at onset); CESC cis rs17331151 0.573 rs11718060 chr3:52875546 G/A cg04865290 chr3:52927548 TMEM110 -0.49 -5.1 -0.3 6.44e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.0 0.39 2.15e-11 Colorectal cancer; CESC trans rs1814175 0.645 rs1851850 chr11:50012168 G/A cg11707556 chr5:10655725 ANKRD33B -0.41 -6.0 -0.35 6.53e-9 Height; CESC cis rs2243480 1.000 rs6970243 chr7:65388490 C/A cg25894440 chr7:65020034 NA -0.59 -5.07 -0.3 7.57e-7 Diabetic kidney disease; CESC cis rs4472734 1.000 rs4275425 chr1:214612500 C/A cg00063699 chr1:214624242 PTPN14 -0.32 -5.04 -0.3 8.6e-7 Height; CESC cis rs11122272 0.735 rs2739509 chr1:231526765 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.13 0.35 3.23e-9 Hemoglobin concentration; CESC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg19257562 chr1:2043853 PRKCZ 0.36 5.95 0.34 8.48e-9 Height; CESC trans rs17508449 0.819 rs79667495 chr1:114191329 T/G cg23028848 chr11:57092561 TNKS1BP1 -0.75 -6.02 -0.35 5.69e-9 Leprosy; CESC cis rs7666738 0.830 rs9996098 chr4:98867740 T/C cg05340658 chr4:99064831 C4orf37 0.74 10.7 0.55 1.97e-22 Colonoscopy-negative controls vs population controls; CESC cis rs941873 0.772 rs1316312 chr10:81110417 G/C cg11057378 chr10:81107060 PPIF 0.35 5.49 0.32 9.18e-8 Height; CESC trans rs9467711 0.606 rs35307327 chr6:26370474 C/T cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC cis rs9815354 0.638 rs75687617 chr3:42044664 C/T cg03022575 chr3:42003672 ULK4 0.76 6.68 0.38 1.39e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs6062302 0.548 rs6089940 chr20:62252695 C/T cg06363034 chr20:62225388 GMEB2 -0.5 -6.41 -0.37 6.66e-10 Glioblastoma; CESC cis rs9633740 1.000 rs1870138 chr10:82269611 A/G cg00277334 chr10:82204260 NA -0.5 -5.11 -0.3 6.19e-7 Post bronchodilator FEV1; CESC trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg03929089 chr4:120376271 NA -0.8 -10.63 -0.55 3.2e-22 Height; CESC cis rs2276314 0.857 rs28530656 chr18:33588700 C/T cg05985134 chr18:33552581 C18orf21 -0.6 -7.39 -0.41 1.98e-12 Endometriosis;Drug-induced torsades de pointes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13409248 chr3:40428643 ENTPD3 -0.46 -6.03 -0.35 5.52e-9 Fibrinogen levels; CESC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg23985595 chr17:80112537 CCDC57 0.42 6.61 0.38 2.14e-10 Life satisfaction; CESC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg02428538 chr16:24856791 SLC5A11 -0.47 -5.03 -0.3 9.12e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.77 0.38 8.24e-11 Prudent dietary pattern; CESC cis rs6582630 0.502 rs1115515 chr12:38279830 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.7 0.51 3.2e-19 Drug-induced liver injury (flucloxacillin); CESC cis rs7872515 0.887 rs58129324 chr9:94839105 T/C cg01248375 chr9:94877805 SPTLC1 0.56 6.1 0.35 3.81e-9 Bipolar disorder and schizophrenia; CESC cis rs4780401 0.678 rs7189287 chr16:11764608 A/G cg01061890 chr16:11836724 TXNDC11 -0.39 -5.06 -0.3 7.71e-7 Rheumatoid arthritis; CESC cis rs2710642 0.721 rs1487074 chr2:62890551 T/C cg17519650 chr2:63277830 OTX1 0.55 6.64 0.38 1.82e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs1707322 1.000 rs12133129 chr1:46373348 C/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs8044868 0.530 rs7201866 chr16:72086534 A/T cg16558253 chr16:72132732 DHX38 -0.39 -6.15 -0.35 2.89e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs17384381 0.734 rs12129013 chr1:85891709 A/C cg16011679 chr1:85725395 C1orf52 0.6 6.74 0.38 1.01e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs6513791 0.663 rs1883269 chr20:41044482 C/T cg20844924 chr4:15328821 NA 0.61 6.06 0.35 4.71e-9 Microalbuminuria; CESC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg04025307 chr7:1156635 C7orf50 0.41 5.21 0.31 3.71e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg18099408 chr3:52552593 STAB1 -0.31 -5.18 -0.3 4.29e-7 Bipolar disorder; CESC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg00106254 chr7:1943704 MAD1L1 -0.49 -6.2 -0.36 2.18e-9 Bipolar disorder and schizophrenia; CESC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.61e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7208859 0.623 rs8067035 chr17:29102188 T/C cg13385521 chr17:29058706 SUZ12P 0.78 6.41 0.37 6.55e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6570726 0.935 rs416987 chr6:145847005 G/C cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 2e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs8014204 0.967 rs2359240 chr14:75328247 T/C cg26191576 chr14:75389716 RPS6KL1 0.36 5.18 0.3 4.44e-7 Caffeine consumption; CESC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.47 -0.32 1.03e-7 Lung cancer; CESC cis rs1511802 0.666 rs4862662 chr4:187118662 A/C cg24794857 chr4:187113578 CYP4V2 -0.44 -5.81 -0.34 1.77e-8 Blood protein levels; CESC cis rs1881797 1.000 rs68059491 chr1:247683070 C/T cg18198730 chr1:247681584 NA 0.62 7.76 0.43 1.9e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs2742234 0.504 rs10899780 chr10:43725796 T/C cg15436174 chr10:43711423 RASGEF1A 0.47 5.5 0.32 8.97e-8 Hirschsprung disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08577743 chr9:38621011 C9orf122;ANKRD18A 0.46 6.23 0.36 1.87e-9 Systemic lupus erythematosus; CESC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.19e-11 Aortic root size; CESC trans rs11098499 1.000 rs11098499 chr4:120187611 C/T cg25214090 chr10:38739885 LOC399744 0.67 9.18 0.49 1.26e-17 Corneal astigmatism; CESC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg07507251 chr3:52567010 NT5DC2 0.43 7.38 0.41 2.01e-12 Bipolar disorder; CESC cis rs12822507 0.811 rs34946234 chr12:12781812 A/G cg09462578 chr12:12878428 APOLD1 -0.44 -5.51 -0.32 8.36e-8 Systemic lupus erythematosus; CESC cis rs8005677 1.000 rs11157930 chr14:23403171 T/G cg25600027 chr14:23388339 RBM23 -0.43 -5.23 -0.31 3.43e-7 Cognitive ability (multi-trait analysis); CESC cis rs1538970 0.816 rs61788356 chr1:46006675 C/T cg03146154 chr1:46216737 IPP 0.49 5.6 0.33 5.25e-8 Platelet count; CESC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg17372223 chr3:52568218 NT5DC2 0.42 6.35 0.36 9.09e-10 Electroencephalogram traits; CESC cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg12927641 chr6:109611667 NA -0.42 -6.4 -0.37 7.18e-10 Reticulocyte fraction of red cells; CESC trans rs1814175 0.645 rs7119101 chr11:49955665 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC cis rs10206020 0.921 rs72778009 chr2:1573322 G/T cg26248373 chr2:1572462 NA -0.6 -7.09 -0.4 1.21e-11 IgG glycosylation; CESC cis rs4919087 1.000 rs4919091 chr10:99088682 A/T cg25902810 chr10:99078978 FRAT1 -0.65 -8.52 -0.46 1.2e-15 Monocyte count; CESC cis rs7267979 1.000 rs6107046 chr20:25442049 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.83 15.81 0.7 4.28e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs208520 1.000 rs72882102 chr6:66983408 C/A cg07460842 chr6:66804631 NA 0.88 10.14 0.53 1.22e-20 Exhaled nitric oxide output; CESC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg06873352 chr17:61820015 STRADA 0.73 13.15 0.63 9.34e-31 Prudent dietary pattern; CESC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.09 0.56 9.7e-24 Alzheimer's disease; CESC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.33 0.31 2.14e-7 Bipolar disorder; CESC cis rs10463316 0.894 rs7729438 chr5:150762197 G/A cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg11764359 chr7:65958608 NA -0.94 -15.61 -0.69 2.16e-39 Aortic root size; CESC cis rs611744 0.647 rs11774904 chr8:109273435 G/A cg21045802 chr8:109455806 TTC35 0.52 6.45 0.37 5.39e-10 Dupuytren's disease; CESC cis rs1670533 0.932 rs13140571 chr4:1054358 T/C cg04106633 chr4:1044584 NA 0.41 5.23 0.31 3.36e-7 Recombination rate (females); CESC cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg20476274 chr7:133979776 SLC35B4 0.64 9.4 0.5 2.72e-18 Mean platelet volume; CESC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg07507251 chr3:52567010 NT5DC2 0.34 5.8 0.34 1.85e-8 Electroencephalogram traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10268125 chr7:120590544 ING3 0.51 6.7 0.38 1.23e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg12463550 chr7:65579703 CRCP -0.45 -5.85 -0.34 1.41e-8 Aortic root size; CESC cis rs113835537 0.529 rs7943327 chr11:66256581 G/C cg24851651 chr11:66362959 CCS 0.45 5.82 0.34 1.67e-8 Airway imaging phenotypes; CESC cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg19077165 chr18:44547161 KATNAL2 -0.5 -6.99 -0.39 2.18e-11 Personality dimensions; CESC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.64 0.38 1.81e-10 Bipolar disorder; CESC cis rs763014 0.932 rs4984898 chr16:641164 G/T cg00908189 chr16:619842 PIGQ 0.64 8.48 0.46 1.63e-15 Height; CESC cis rs1005277 0.505 rs200937 chr10:38135772 T/C cg25427524 chr10:38739819 LOC399744 -0.68 -10.02 -0.52 3.01e-20 Extrinsic epigenetic age acceleration; CESC cis rs7208859 0.673 rs9899349 chr17:29200122 C/T cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9814567 1.000 rs9990351 chr3:134239191 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.43 5.95 0.34 8.44e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg11965913 chr1:205819406 PM20D1 0.45 6.59 0.38 2.34e-10 Prostate cancer; CESC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg05368731 chr17:41323189 NBR1 0.75 10.35 0.54 2.72e-21 Menopause (age at onset); CESC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.93 -0.56 3.47e-23 Alzheimer's disease; CESC cis rs763121 0.853 rs1062687 chr22:39134715 T/C cg21395723 chr22:39101663 GTPBP1 0.49 6.7 0.38 1.23e-10 Menopause (age at onset); CESC cis rs1044826 0.692 rs184155 chr3:139229772 G/A cg00490450 chr3:139108681 COPB2 -0.44 -5.43 -0.32 1.31e-7 Obesity-related traits; CESC cis rs4268898 0.662 rs714531 chr2:24399877 G/A cg06627628 chr2:24431161 ITSN2 -0.98 -9.85 -0.52 1.06e-19 Asthma; CESC cis rs2204008 0.604 rs2320521 chr12:38253789 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.7 0.51 3.2e-19 Bladder cancer; CESC cis rs4604732 0.631 rs12031721 chr1:247623773 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.1 0.3 6.5e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6484504 0.600 rs972714 chr11:31358875 T/G cg14844989 chr11:31128820 NA 0.38 5.16 0.3 4.92e-7 Red blood cell count; CESC cis rs1983891 1.000 rs6458228 chr6:41543793 C/A cg20194872 chr6:41519635 FOXP4 0.55 7.76 0.43 1.88e-13 Prostate cancer; CESC cis rs35110281 0.807 rs9976441 chr21:45046591 G/A cg21573476 chr21:45109991 RRP1B -0.46 -6.4 -0.37 7.1e-10 Mean corpuscular volume; CESC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg19346786 chr7:2764209 NA -0.42 -5.91 -0.34 1.02e-8 Height; CESC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg03264133 chr6:25882463 NA -0.49 -7.22 -0.41 5.49e-12 Intelligence (multi-trait analysis); CESC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg04772025 chr11:68637568 NA 0.51 6.04 0.35 5.22e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs35955747 0.871 rs5994392 chr22:31783906 T/A cg25791279 chr22:32026902 PISD -0.44 -5.37 -0.31 1.76e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg06877462 chr1:205807181 PM20D1 -0.4 -5.99 -0.35 6.7e-9 Menarche (age at onset); CESC cis rs7647973 0.580 rs35218722 chr3:49275805 A/G cg07636037 chr3:49044803 WDR6 0.81 13.66 0.64 1.62e-32 Menarche (age at onset); CESC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg18099408 chr3:52552593 STAB1 -0.3 -5.03 -0.3 8.99e-7 Bipolar disorder; CESC cis rs1707322 0.721 rs4330955 chr1:46217485 G/C cg06784218 chr1:46089804 CCDC17 0.43 7.58 0.42 5.65e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4073405 0.584 rs6485607 chr11:45306531 G/A cg27235148 chr11:45376932 NA 0.29 5.03 0.3 9.19e-7 Schizophrenia; CESC cis rs4780401 0.609 rs4781142 chr16:11808806 T/C cg01061890 chr16:11836724 TXNDC11 -0.56 -7.59 -0.42 5.59e-13 Rheumatoid arthritis; CESC cis rs67478160 0.619 rs11160759 chr14:104231542 C/T cg08213375 chr14:104286397 PPP1R13B 0.55 11.09 0.56 9.71e-24 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01516466 chr9:3526944 RFX3 -0.58 -6.48 -0.37 4.37e-10 Gut microbiome composition (summer); CESC cis rs1538970 0.884 rs61788261 chr1:45899114 G/A cg05343316 chr1:45956843 TESK2 0.9 12.61 0.61 7.33e-29 Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10827434 chr1:84944976 RPF1 0.66 7.44 0.42 1.41e-12 Gut microbiome composition (summer); CESC trans rs4332037 0.950 rs7807014 chr7:1939021 T/C cg11693508 chr17:37793320 STARD3 0.67 6.4 0.37 6.96e-10 Bipolar disorder; CESC cis rs9902453 0.904 rs11654983 chr17:28370042 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -8.69 -0.47 3.8e-16 Coffee consumption (cups per day); CESC trans rs2727020 0.619 rs11040300 chr11:49269984 C/A cg15704280 chr7:45808275 SEPT13 0.79 10.11 0.53 1.51e-20 Coronary artery disease; CESC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg10691866 chr7:65817282 TPST1 0.31 5.21 0.3 3.81e-7 Aortic root size; CESC trans rs453301 0.624 rs330058 chr8:9089809 G/A cg15556689 chr8:8085844 FLJ10661 -0.53 -6.6 -0.38 2.25e-10 Joint mobility (Beighton score); CESC trans rs10411161 0.702 rs8110546 chr19:52383556 C/A cg22319618 chr22:45562946 NUP50 -0.69 -6.75 -0.38 9.37e-11 Breast cancer; CESC cis rs2576037 0.796 rs2571018 chr18:44585344 T/A cg19077165 chr18:44547161 KATNAL2 0.54 7.57 0.42 6.29e-13 Personality dimensions; CESC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.48 0.37 4.37e-10 Depression; CESC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg07677032 chr17:61819896 STRADA 0.41 5.15 0.3 4.97e-7 Height; CESC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg18876405 chr7:65276391 NA -0.65 -8.93 -0.48 7.45e-17 Aortic root size; CESC cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg21395723 chr22:39101663 GTPBP1 0.42 5.32 0.31 2.17e-7 Menopause (age at onset); CESC cis rs796364 0.806 rs11688194 chr2:200916239 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.75 -0.43 1.94e-13 Schizophrenia; CESC cis rs11112613 0.713 rs871220 chr12:105938558 G/A cg03607813 chr12:105948248 NA 0.65 7.98 0.44 4.53e-14 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg04703951 chr17:43578652 NA 0.5 6.0 0.35 6.62e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12477438 0.765 rs10181344 chr2:99692829 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs13191362 1.000 rs35583420 chr6:163214327 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.96 8.86 0.48 1.2e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs826838 0.967 rs4768330 chr12:39129399 T/C cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs6460942 0.591 rs62451464 chr7:12363059 C/A cg06484146 chr7:12443880 VWDE -0.62 -6.74 -0.38 9.67e-11 Coronary artery disease; CESC cis rs965469 0.779 rs6133039 chr20:3385006 C/T cg17110299 chr20:3385021 C20orf194 0.38 5.12 0.3 5.97e-7 IFN-related cytopenia; CESC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg06221963 chr1:154839813 KCNN3 -0.7 -12.23 -0.6 1.49e-27 Prostate cancer; CESC cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg26116260 chr4:7069785 GRPEL1 0.98 14.35 0.66 5.85e-35 Monocyte percentage of white cells; CESC cis rs5758659 0.623 rs133328 chr22:42408079 T/C cg04733989 chr22:42467013 NAGA 0.47 6.37 0.36 8.53e-10 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21164723 chr1:214776304 CENPF 0.59 6.97 0.39 2.46e-11 Gut microbiome composition (summer); CESC cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg12386194 chr3:101231763 SENP7 0.6 6.65 0.38 1.68e-10 Colonoscopy-negative controls vs population controls; CESC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg04772025 chr11:68637568 NA 0.55 6.25 0.36 1.67e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9419702 0.568 rs9419635 chr10:133546164 C/T cg04492858 chr10:133558786 NA 0.46 6.73 0.38 1.06e-10 Survival in rectal cancer; CESC cis rs9325144 0.560 rs11183090 chr12:38662293 G/C cg13010199 chr12:38710504 ALG10B -0.45 -6.1 -0.35 3.79e-9 Morning vs. evening chronotype; CESC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg21782813 chr7:2030301 MAD1L1 0.49 7.07 0.4 1.4e-11 Bipolar disorder and schizophrenia; CESC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg22535103 chr8:58192502 C8orf71 -0.69 -7.61 -0.42 4.76e-13 Developmental language disorder (linguistic errors); CESC cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg18446336 chr7:2847575 GNA12 -0.38 -6.45 -0.37 5.17e-10 Height; CESC cis rs7212590 0.581 rs8081710 chr17:57838040 G/A cg20303301 chr17:57937339 TUBD1 -0.55 -5.18 -0.3 4.34e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs9815354 0.767 rs73077375 chr3:41853058 C/T cg03022575 chr3:42003672 ULK4 0.7 6.32 0.36 1.08e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs4474465 0.790 rs4492845 chr11:78260161 C/T cg27205649 chr11:78285834 NARS2 0.42 5.27 0.31 2.88e-7 Alzheimer's disease (survival time); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15273368 chr10:104221031 TMEM180 -0.48 -6.77 -0.38 8.39e-11 Fibrinogen levels; CESC trans rs61931739 0.517 rs34760282 chr12:34153711 G/T cg26384229 chr12:38710491 ALG10B 0.64 9.06 0.49 2.9e-17 Morning vs. evening chronotype; CESC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg07507251 chr3:52567010 NT5DC2 0.4 7.06 0.4 1.49e-11 Bipolar disorder; CESC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg12963246 chr6:28129442 ZNF389 0.43 6.3 0.36 1.25e-9 Parkinson's disease; CESC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg24733560 chr20:60626293 TAF4 0.45 6.44 0.37 5.45e-10 Body mass index; CESC cis rs9814567 1.000 rs7428326 chr3:134251184 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.15 -0.35 2.87e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2733201 1.000 rs2623019 chr15:44399628 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.63 -5.83 -0.34 1.61e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15164871 chr12:123380523 VPS37B 0.61 7.25 0.41 4.58e-12 Gut microbiome composition (summer); CESC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg07507251 chr3:52567010 NT5DC2 0.32 5.53 0.32 7.76e-8 Bipolar disorder; CESC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg03351412 chr1:154909251 PMVK 0.69 9.25 0.49 7.88e-18 Prostate cancer; CESC trans rs637571 0.654 rs1058068 chr11:65667796 G/A cg17712092 chr4:129076599 LARP1B 0.95 13.56 0.64 3.71e-32 Eosinophil percentage of white cells; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg09365624 chr1:87597710 LOC339524 -0.53 -6.09 -0.35 3.96e-9 Subjective well-being; CESC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg19468946 chr17:37922297 IKZF3 0.39 5.12 0.3 5.95e-7 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18279994 chr2:54950960 EML6 0.62 6.77 0.38 8.43e-11 Gut microbiome composition (summer); CESC cis rs7267979 0.586 rs6083776 chr20:25186116 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.66 10.94 0.56 3.16e-23 Liver enzyme levels (alkaline phosphatase); CESC cis rs9926296 0.593 rs6500456 chr16:89888341 T/C cg27121462 chr16:89883253 FANCA 0.56 6.87 0.39 4.59e-11 Vitiligo; CESC cis rs72781680 0.898 rs17462558 chr2:24020812 T/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs2408955 0.522 rs4760612 chr12:48421856 C/T cg04545296 chr12:48745243 ZNF641 -0.35 -6.1 -0.35 3.79e-9 Glycated hemoglobin levels; CESC cis rs2011503 0.882 rs72999030 chr19:19364240 A/T cg11584989 chr19:19387371 SF4 0.53 6.41 0.37 6.52e-10 Bipolar disorder; CESC cis rs9398803 0.673 rs1262557 chr6:127054588 C/T cg19875578 chr6:126661172 C6orf173 -0.42 -5.52 -0.32 8.13e-8 Male-pattern baldness; CESC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.79 0.43 1.49e-13 Prudent dietary pattern; CESC cis rs4974559 0.501 rs1250129 chr4:1254930 C/T cg05025164 chr4:1340916 KIAA1530 0.53 5.6 0.33 5.35e-8 Systolic blood pressure; CESC cis rs1223245 0.740 rs360063 chr1:226036309 A/G cg27179622 chr1:226127290 LEFTY2 -0.35 -5.26 -0.31 2.95e-7 Preschool internalizing problems; CESC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg11764359 chr7:65958608 NA 0.73 10.55 0.54 5.73e-22 Aortic root size; CESC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg21770322 chr7:97807741 LMTK2 0.55 8.08 0.44 2.32e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg17724175 chr1:150552817 MCL1 0.42 6.42 0.37 6.31e-10 Melanoma; CESC cis rs4604732 0.631 rs10925043 chr1:247627001 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC trans rs6991952 0.845 rs7822766 chr8:25742279 A/T cg01353569 chr7:106810328 HBP1 -0.5 -6.2 -0.36 2.11e-9 Inguinal hernia; CESC cis rs826838 0.967 rs1684411 chr12:39128494 C/T cg13010199 chr12:38710504 ALG10B -0.44 -5.97 -0.34 7.74e-9 Heart rate; CESC cis rs6933660 0.683 rs8180642 chr6:151756612 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.61 8.47 0.46 1.76e-15 Menarche (age at onset); CESC cis rs7116495 1.000 rs73539532 chr11:71815684 C/A cg26138937 chr11:71823887 C11orf51 0.85 6.85 0.39 5.03e-11 Severe influenza A (H1N1) infection; CESC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08989921 chr17:76836740 USP36 -0.52 -6.73 -0.38 1.04e-10 Ulcerative colitis; CESC cis rs8067354 0.574 rs2531898 chr17:58012351 G/C cg02344993 chr17:57696989 CLTC 0.53 5.47 0.32 1.03e-7 Hemoglobin concentration; CESC cis rs6088580 0.634 rs6088471 chr20:32932643 C/A cg06115741 chr20:33292138 TP53INP2 -0.46 -5.85 -0.34 1.45e-8 Glomerular filtration rate (creatinine); CESC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 -0.43 -5.52 -0.32 8.26e-8 Tonsillectomy; CESC cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg12648201 chr2:27665141 KRTCAP3 -0.36 -6.38 -0.36 7.97e-10 Total body bone mineral density; CESC cis rs9611565 0.649 rs5758344 chr22:41817685 G/A cg06634786 chr22:41940651 POLR3H 0.73 7.3 0.41 3.43e-12 Vitiligo; CESC cis rs897984 0.542 rs11864806 chr16:31095204 G/C cg00531865 chr16:30841666 NA -0.39 -5.42 -0.32 1.33e-7 Dementia with Lewy bodies; CESC trans rs35146811 0.700 rs858513 chr7:99825558 G/A cg13215871 chr17:75784724 NA -0.34 -6.39 -0.37 7.46e-10 Coronary artery disease; CESC cis rs2859741 0.967 rs494157 chr1:37512995 C/T cg09363841 chr1:37513479 NA 0.7 11.79 0.59 4.34e-26 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs4268898 0.662 rs2891380 chr2:24525830 G/A cg06627628 chr2:24431161 ITSN2 -0.98 -11.27 -0.57 2.51e-24 Asthma; CESC cis rs10883723 0.773 rs11191303 chr10:104255158 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.43 0.42 1.49e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs9814567 0.896 rs7653807 chr3:134345724 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.67 -0.33 3.63e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9549367 0.789 rs2287248 chr13:113889226 T/C cg18105134 chr13:113819100 PROZ -0.65 -7.73 -0.43 2.24e-13 Platelet distribution width; CESC cis rs4805272 0.512 rs8106166 chr19:29339578 A/G cg12756686 chr19:29218302 NA -0.44 -5.86 -0.34 1.35e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs4727027 0.865 rs13236754 chr7:148845773 G/A cg23158103 chr7:148848205 ZNF398 -0.43 -7.01 -0.4 1.96e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg16278512 chr7:12443529 VWDE -0.55 -5.87 -0.34 1.27e-8 Coronary artery disease; CESC cis rs3754214 0.823 rs494041 chr1:150270026 T/C cg09579323 chr1:150459698 TARS2 -0.47 -6.18 -0.35 2.44e-9 Cerebrospinal fluid biomarker levels; CESC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16256719 chr1:228613082 HIST3H3 -0.59 -6.52 -0.37 3.6e-10 Gut microbiome composition (summer); CESC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg07701084 chr6:150067640 NUP43 0.42 5.78 0.33 2.07e-8 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22692790 chr10:70748415 KIAA1279 -0.62 -7.08 -0.4 1.33e-11 Gut microbiome composition (summer); CESC cis rs11997175 0.583 rs17780571 chr8:33817821 G/C ch.8.33884649F chr8:33765107 NA 0.46 5.75 0.33 2.44e-8 Body mass index; CESC cis rs7481584 0.962 rs11024766 chr11:2984645 C/G cg25174290 chr11:3078921 CARS -0.5 -6.01 -0.35 6.01e-9 Calcium levels; CESC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg08736216 chr1:53307985 ZYG11A -0.41 -6.9 -0.39 3.83e-11 Monocyte count; CESC cis rs611744 0.967 rs655722 chr8:109197541 A/T cg21045802 chr8:109455806 TTC35 0.42 5.32 0.31 2.19e-7 Dupuytren's disease; CESC cis rs763121 0.853 rs5757162 chr22:38993370 C/T cg06022373 chr22:39101656 GTPBP1 0.84 12.24 0.6 1.36e-27 Menopause (age at onset); CESC cis rs7917772 0.582 rs10786683 chr10:104320476 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 5.71 0.33 3.08e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs5760092 0.618 rs4461358 chr22:24260106 T/C cg12419862 chr22:24373484 LOC391322 0.81 10.51 0.54 8.1e-22 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs7264396 0.790 rs6058297 chr20:34271861 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.84 -0.59 2.93e-26 Total cholesterol levels; CESC cis rs2235642 0.893 rs2143285 chr16:1593171 A/G cg07639376 chr16:1584516 IFT140;TMEM204 -0.33 -5.26 -0.31 3.04e-7 Coronary artery disease; CESC cis rs738322 0.726 rs5750561 chr22:38595260 A/T cg17652424 chr22:38574118 PLA2G6 0.31 5.39 0.31 1.53e-7 Cutaneous nevi; CESC cis rs9914988 0.943 rs9890155 chr17:27125467 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg24562669 chr7:97807699 LMTK2 0.51 7.63 0.42 4.29e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs4243830 0.850 rs4908915 chr1:6601607 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.93 -8.7 -0.47 3.49e-16 Body mass index; CESC cis rs9916302 0.821 rs11078916 chr17:37746307 T/C cg00129232 chr17:37814104 STARD3 -0.7 -9.13 -0.49 1.86e-17 Glomerular filtration rate (creatinine); CESC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg16145915 chr7:1198662 ZFAND2A -0.45 -6.48 -0.37 4.36e-10 Longevity;Endometriosis; CESC cis rs9457247 0.637 rs9459846 chr6:167441023 T/G cg23791538 chr6:167370224 RNASET2 -0.57 -7.71 -0.43 2.6e-13 Crohn's disease; CESC cis rs6598955 0.671 rs17257176 chr1:26578233 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC cis rs2637266 0.628 rs846632 chr10:78535759 C/A cg18941641 chr10:78392320 NA 0.42 8.34 0.46 4.01e-15 Pulmonary function; CESC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.1 0.4 1.11e-11 Height; CESC cis rs36051895 0.589 rs11790596 chr9:5198335 T/C cg02405213 chr9:5042618 JAK2 -0.56 -6.85 -0.39 5.09e-11 Pediatric autoimmune diseases; CESC cis rs9916302 0.752 rs6503513 chr17:37561613 A/G cg00129232 chr17:37814104 STARD3 0.56 6.5 0.37 3.99e-10 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7914558 1.000 rs7077097 chr10:104945463 G/A cg04362960 chr10:104952993 NT5C2 0.46 6.16 0.35 2.74e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.58 -9.13 -0.49 1.79e-17 Axial length; CESC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg09877947 chr5:131593287 PDLIM4 0.46 6.15 0.35 2.84e-9 Breast cancer; CESC cis rs870825 0.746 rs1107908 chr4:185620113 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg26354017 chr1:205819088 PM20D1 0.43 5.58 0.32 5.98e-8 Parkinson's disease; CESC cis rs60843830 0.964 rs17713568 chr2:242132 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.79 10.3 0.53 3.78e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4450131 0.522 rs35645049 chr10:126368119 C/G cg20435097 chr10:126320824 FAM53B 0.29 5.26 0.31 2.94e-7 White blood cell count (basophil); CESC cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg20821713 chr7:1055600 C7orf50 -0.5 -6.5 -0.37 4.04e-10 Bronchopulmonary dysplasia; CESC cis rs798554 0.591 rs1182156 chr7:2901084 G/T cg19717773 chr7:2847554 GNA12 -0.5 -7.53 -0.42 8.18e-13 Height; CESC cis rs8014204 0.935 rs8010840 chr14:75355203 T/C cg26191576 chr14:75389716 RPS6KL1 0.36 5.19 0.3 4.2e-7 Caffeine consumption; CESC cis rs1538970 0.816 rs10789464 chr1:45959102 C/T cg24296786 chr1:45957014 TESK2 -0.47 -5.2 -0.3 4e-7 Platelet count; CESC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg18904891 chr8:8559673 CLDN23 0.71 8.29 0.45 5.61e-15 Obesity-related traits; CESC cis rs80130819 0.688 rs4760692 chr12:48587549 T/C cg07561017 chr12:48398056 COL2A1 0.38 5.13 0.3 5.71e-7 Prostate cancer; CESC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg23281280 chr6:28129359 ZNF389 0.56 7.6 0.42 5.19e-13 Depression; CESC cis rs7089973 0.836 rs12765350 chr10:116635305 G/A cg25233709 chr10:116636983 FAM160B1 0.34 5.03 0.3 9.07e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11039798 1.000 rs6485848 chr11:48541517 G/T cg15704280 chr7:45808275 SEPT13 0.7 6.6 0.38 2.27e-10 Axial length; CESC cis rs561341 1.000 rs560132 chr17:30320019 C/T cg12193833 chr17:30244370 NA -0.76 -6.99 -0.39 2.21e-11 Hip circumference adjusted for BMI; CESC trans rs62140779 0.524 rs76045944 chr2:58618545 T/C cg16116203 chr12:6876922 PTMS 0.51 6.04 0.35 5.19e-9 Neuroticism; CESC cis rs2950393 0.929 rs2958155 chr12:57064545 A/C cg05584118 chr12:57595605 LRP1 -0.37 -5.23 -0.31 3.44e-7 Platelet distribution width; CESC cis rs9486715 0.867 rs9386500 chr6:96889845 A/C cg06623918 chr6:96969491 KIAA0776 0.93 14.47 0.66 2.36e-35 Headache; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12227505 chr17:78194145 SLC26A11;SGSH -0.43 -6.14 -0.35 3.01e-9 Fibrinogen levels; CESC cis rs7697216 0.668 rs28465148 chr4:175850605 T/G cg14561282 chr4:175839468 ADAM29 0.49 5.48 0.32 1e-7 Breast cancer; CESC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg04944784 chr2:26401820 FAM59B -0.74 -8.28 -0.45 6.01e-15 Gut microbiome composition (summer); CESC cis rs7793239 0.550 rs10246191 chr7:130029811 G/A cg04743876 chr7:130013617 NA 0.32 5.97 0.34 7.57e-9 Antipsychotic drug-induced QTc interval change in schizophrenia; CESC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg24675658 chr1:53192096 ZYG11B 0.52 6.52 0.37 3.55e-10 Monocyte count; CESC cis rs1983170 0.736 rs12127718 chr1:91997490 A/T cg25838465 chr1:92012736 NA 0.44 5.08 0.3 7.1e-7 Eosinophil percentage of white cells; CESC cis rs11920090 0.860 rs7643425 chr3:170737395 A/G cg09710316 chr3:170744871 SLC2A2 0.45 5.35 0.31 1.94e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC cis rs6987853 0.901 rs2923429 chr8:42389743 A/G cg09913449 chr8:42400586 C8orf40 0.39 6.13 0.35 3.15e-9 Mean corpuscular hemoglobin concentration; CESC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 10.81 0.55 8.61e-23 Platelet count; CESC trans rs916888 0.773 rs199439 chr17:44793503 A/G cg22968622 chr17:43663579 NA 1.32 18.48 0.75 1.44e-49 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7208859 0.623 rs79607958 chr17:28934548 T/G cg13385521 chr17:29058706 SUZ12P 0.78 5.67 0.33 3.78e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7904368 0.806 rs7899853 chr10:16857603 A/T cg23933602 chr10:16859644 RSU1 0.68 6.32 0.36 1.08e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CESC cis rs67311347 1.000 rs9874006 chr3:40471596 G/A cg09455208 chr3:40491958 NA 0.44 7.56 0.42 6.79e-13 Renal cell carcinoma; CESC cis rs116095464 0.558 rs1541822 chr5:269234 A/C cg20965017 chr5:231967 SDHA 0.45 5.05 0.3 8.36e-7 Breast cancer; CESC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg00800038 chr16:89945340 TCF25 -0.92 -7.62 -0.42 4.38e-13 Skin colour saturation; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg16811695 chr10:115999009 VWA2 0.45 6.36 0.36 9.04e-10 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20412726 chr6:167412529 FGFR1OP 0.57 6.82 0.39 5.97e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg18180107 chr4:99064573 C4orf37 0.42 5.44 0.32 1.2e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9486719 1.000 rs2472888 chr6:96865501 T/C cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 12.96 0.62 4.51e-30 Platelet count; CESC cis rs3008870 0.755 rs2208577 chr1:67513574 A/C cg02640540 chr1:67518911 SLC35D1 0.71 9.11 0.49 2.03e-17 Lymphocyte percentage of white cells; CESC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg12648201 chr2:27665141 KRTCAP3 -0.36 -6.64 -0.38 1.76e-10 Total body bone mineral density; CESC trans rs220324 1.000 rs220324 chr21:43586699 C/T cg08141495 chr18:31739521 NOL4 0.29 6.06 0.35 4.58e-9 Idiopathic osteonecrosis of the femoral head; CESC cis rs4722166 0.508 rs1474348 chr7:22767908 C/G cg05472934 chr7:22766657 IL6 0.83 11.08 0.56 1.04e-23 Lung cancer; CESC cis rs72634258 0.554 rs68024107 chr1:7914066 G/C cg26816564 chr1:7831052 VAMP3 0.49 5.16 0.3 4.9e-7 Inflammatory bowel disease; CESC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg19163074 chr7:65112434 INTS4L2 0.42 5.13 0.3 5.63e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02031769 chr6:161695303 AGPAT4 -0.55 -6.04 -0.35 5.12e-9 Gut microbiome composition (summer); CESC cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg22862634 chr11:62369728 EML3;MTA2 0.57 7.88 0.44 8.65e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg10150615 chr22:24372951 LOC391322 0.57 7.78 0.43 1.59e-13 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg11752832 chr7:134001865 SLC35B4 0.58 7.62 0.42 4.5e-13 Mean platelet volume; CESC cis rs116095464 0.558 rs10075018 chr5:239175 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.58 -0.47 8.28e-16 Breast cancer; CESC cis rs3820068 0.608 rs10927831 chr1:16028373 T/G cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.35 4.28e-9 Systolic blood pressure; CESC cis rs4423214 0.592 rs7120029 chr11:71198957 G/A cg05163923 chr11:71159392 DHCR7 -0.55 -6.01 -0.35 6.09e-9 Vitamin D levels; CESC cis rs10875943 0.751 rs56222401 chr12:49672714 A/G cg14846292 chr12:49726500 C1QL4 -0.37 -5.14 -0.3 5.31e-7 Prostate cancer; CESC cis rs4268898 0.932 rs7577964 chr2:24598279 A/G cg06627628 chr2:24431161 ITSN2 0.64 7.48 0.42 1.1e-12 Asthma; CESC cis rs2204008 0.837 rs11495722 chr12:38337245 G/A cg26384229 chr12:38710491 ALG10B 0.75 10.74 0.55 1.42e-22 Bladder cancer; CESC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -8.18 -0.45 1.19e-14 Developmental language disorder (linguistic errors); CESC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.22 0.31 3.62e-7 Menopause (age at onset); CESC cis rs9900062 0.507 rs7225993 chr17:62708284 C/G cg02598441 chr17:62777298 LOC146880 -0.59 -6.52 -0.37 3.56e-10 QT interval; CESC cis rs3749237 0.595 rs4855873 chr3:49459114 A/C cg03060546 chr3:49711283 APEH 0.76 11.67 0.58 1.11e-25 Resting heart rate; CESC cis rs7267979 1.000 rs6050573 chr20:25366065 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 18.14 0.74 2.36e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs2832191 1.000 rs2832184 chr21:30483265 C/T cg08807101 chr21:30365312 RNF160 -0.67 -9.26 -0.49 7.29e-18 Dental caries; CESC cis rs11785400 0.793 rs1056012 chr8:143740167 A/G cg10596483 chr8:143751796 JRK 0.42 5.31 0.31 2.32e-7 Schizophrenia; CESC cis rs4888262 0.508 rs7193583 chr16:74649589 C/G cg01733217 chr16:74700730 RFWD3 0.87 12.3 0.6 8.07e-28 Testicular germ cell tumor; CESC cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -7.7 -0.43 2.68e-13 Personality dimensions; CESC cis rs5753618 0.504 rs7284622 chr22:31907985 G/A cg02404636 chr22:31891804 SFI1 0.43 5.96 0.34 7.98e-9 Colorectal cancer; CESC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg18490616 chr2:88469792 THNSL2 -0.52 -7.74 -0.43 2.04e-13 Response to metformin (IC50); CESC cis rs10905065 0.930 rs7909988 chr10:5736388 A/T cg11519256 chr10:5708881 ASB13 0.44 5.62 0.33 4.95e-8 Menopause (age at onset); CESC cis rs4566357 0.521 rs78411533 chr2:227910807 G/A cg11843606 chr2:227700838 RHBDD1 -0.47 -6.49 -0.37 4.32e-10 Coronary artery disease; CESC cis rs4974559 0.739 rs28573879 chr4:1285910 C/T cg02980000 chr4:1222292 CTBP1 0.81 7.39 0.41 1.88e-12 Systolic blood pressure; CESC cis rs8180040 0.966 rs2062278 chr3:47416761 C/T cg27129171 chr3:47204927 SETD2 0.61 9.39 0.5 2.95e-18 Colorectal cancer; CESC cis rs12911832 1.000 rs12911832 chr15:58985904 A/T cg05156742 chr15:59063176 FAM63B 0.51 6.13 0.35 3.13e-9 Schizophrenia; CESC cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg24110177 chr3:50126178 RBM5 -0.53 -7.36 -0.41 2.33e-12 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07522190 chr16:28925877 RABEP2 -0.54 -6.34 -0.36 9.77e-10 Gut microbiome composition (summer); CESC cis rs950169 0.579 rs62027818 chr15:84661145 T/C cg17507749 chr15:85114479 UBE2QP1 0.63 6.07 0.35 4.33e-9 Schizophrenia; CESC cis rs6088580 0.634 rs6087587 chr20:33058628 G/T cg24642439 chr20:33292090 TP53INP2 0.52 6.9 0.39 3.73e-11 Glomerular filtration rate (creatinine); CESC cis rs4660306 0.848 rs1088099 chr1:45946654 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.62 7.71 0.43 2.56e-13 Homocysteine levels; CESC cis rs2315504 0.626 rs2957100 chr17:39004145 A/G cg05063374 chr17:38953512 KRT28 0.38 5.27 0.31 2.78e-7 Height; CESC cis rs4077515 0.967 rs4266763 chr9:139289825 C/T cg14169450 chr9:139327907 INPP5E -0.36 -5.15 -0.3 5.13e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC trans rs4332037 0.539 rs62444881 chr7:2052318 C/T cg11693508 chr17:37793320 STARD3 0.68 6.85 0.39 5.01e-11 Bipolar disorder; CESC cis rs2072499 0.833 rs2758605 chr1:156200445 G/C cg24450063 chr1:156163899 SLC25A44 0.82 12.64 0.61 5.76e-29 Testicular germ cell tumor; CESC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.68 7.21 0.41 5.82e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs644799 0.965 rs598876 chr11:95560853 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.76 0.38 8.51e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2439831 0.681 rs511673 chr15:43618863 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.85 12.74 0.62 2.55e-29 Lung cancer in ever smokers; CESC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg18350739 chr11:68623251 NA -0.46 -6.9 -0.39 3.76e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72627123 0.656 rs77660260 chr14:74569573 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.74 5.12 0.3 5.89e-7 Morning vs. evening chronotype; CESC cis rs1375194 0.606 rs10188817 chr2:33815471 A/G cg04131969 chr2:33951647 MYADML -0.52 -6.6 -0.38 2.28e-10 Response to antidepressants in depression; CESC cis rs11864453 0.612 rs11862813 chr16:72132356 C/T cg01557791 chr16:72042693 DHODH -0.43 -5.65 -0.33 4.15e-8 Fibrinogen levels; CESC cis rs7580658 0.929 rs4150496 chr2:128029503 C/T cg10021288 chr2:128175891 PROC -0.4 -6.25 -0.36 1.6e-9 Protein C levels; CESC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg01763666 chr17:80159506 CCDC57 -0.37 -5.1 -0.3 6.55e-7 Life satisfaction; CESC cis rs11122272 0.701 rs2790894 chr1:231505587 T/A cg06096015 chr1:231504339 EGLN1 0.4 5.74 0.33 2.58e-8 Hemoglobin concentration; CESC cis rs8051149 0.688 rs12444670 chr16:87870312 C/T cg03408354 chr16:87871219 SLC7A5 -0.45 -5.6 -0.33 5.3e-8 Blood metabolite levels; CESC cis rs11098499 0.863 rs13149407 chr4:120437825 A/G cg24375607 chr4:120327624 NA 0.43 5.13 0.3 5.73e-7 Corneal astigmatism; CESC cis rs2180341 0.920 rs6916990 chr6:127698759 G/A cg24812749 chr6:127587940 RNF146 1.04 14.79 0.67 1.71e-36 Breast cancer; CESC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg25072359 chr17:41440525 NA 0.43 5.78 0.33 2.04e-8 Menopause (age at onset); CESC cis rs919433 0.783 rs2565165 chr2:198233575 T/G cg10820045 chr2:198174542 NA 0.41 5.93 0.34 9.6e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg26408565 chr15:76604113 ETFA -0.44 -6.54 -0.37 3.15e-10 Blood metabolite levels; CESC cis rs57506017 0.585 rs12667950 chr7:12268468 G/T cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.58e-7 Neuroticism; CESC trans rs4824093 0.610 rs4141437 chr22:50243719 C/G cg09872104 chr7:134855509 C7orf49 0.9 6.4 0.37 6.9e-10 Amyotrophic lateral sclerosis (sporadic); CESC cis rs4654899 0.643 rs2053981 chr1:21227083 G/A cg05370193 chr1:21551575 ECE1 0.36 5.46 0.32 1.08e-7 Superior frontal gyrus grey matter volume; CESC cis rs644799 0.625 rs1255177 chr11:95471495 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.45 6.03 0.35 5.6e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9815354 0.812 rs73071343 chr3:41826877 G/C cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs6690583 0.623 rs6679539 chr1:85479457 G/T cg11262906 chr1:85462892 MCOLN2 -0.53 -5.12 -0.3 5.75e-7 Serum sulfate level; CESC cis rs4822044 0.560 rs7284839 chr22:42010902 C/T cg06481639 chr22:41940642 POLR3H 0.6 6.14 0.35 2.95e-9 Cannabis dependence symptom count; CESC cis rs735539 1.000 rs6490606 chr13:21285096 C/G cg04906043 chr13:21280425 IL17D 0.39 6.12 0.35 3.32e-9 Dental caries; CESC cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg02297831 chr4:17616191 MED28 0.55 6.92 0.39 3.33e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs854765 0.583 rs9913724 chr17:17819101 A/G cg09796270 chr17:17721594 SREBF1 0.42 5.95 0.34 8.29e-9 Total body bone mineral density; CESC cis rs654950 0.875 rs600109 chr1:41998246 A/G cg06885757 chr1:42089581 HIVEP3 -0.48 -7.36 -0.41 2.36e-12 Airway imaging phenotypes; CESC cis rs2108225 0.714 rs929393 chr7:107437048 C/T cg18560240 chr7:107437656 SLC26A3 -0.49 -6.9 -0.39 3.89e-11 Ulcerative colitis; CESC cis rs7927592 0.956 rs11228258 chr11:68254328 A/C cg20283391 chr11:68216788 NA 0.51 6.42 0.37 6.43e-10 Total body bone mineral density; CESC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs3936840 0.548 rs1190545 chr14:102904179 G/C cg18135206 chr14:102964638 TECPR2 -0.43 -5.34 -0.31 1.99e-7 Plateletcrit; CESC cis rs6582630 0.555 rs4601853 chr12:38435569 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.05 0.35 5.01e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs644799 0.965 rs11021317 chr11:95517576 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.66 0.67 4.93e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4253772 0.591 rs9615938 chr22:46689468 G/A cg24881330 chr22:46731750 TRMU 0.73 5.24 0.31 3.32e-7 LDL cholesterol;Cholesterol, total; CESC cis rs2228479 0.850 rs45524643 chr16:89815824 G/A cg19635926 chr16:89946313 TCF25 0.67 5.09 0.3 6.82e-7 Skin colour saturation; CESC cis rs7647973 1.000 rs9871024 chr3:49554241 T/C cg07636037 chr3:49044803 WDR6 -0.72 -10.34 -0.54 2.85e-21 Menarche (age at onset); CESC cis rs12971120 0.838 rs747176 chr18:72154931 G/A cg26446133 chr18:72167187 CNDP2 -0.67 -9.01 -0.48 4.21e-17 Refractive error; CESC cis rs1008375 0.866 rs12233712 chr4:17570063 T/A cg02297831 chr4:17616191 MED28 0.45 5.41 0.32 1.41e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1711745 0.702 rs2995805 chr9:115454618 T/C cg13803584 chr9:115635662 SNX30 0.53 5.1 0.3 6.48e-7 Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy); CESC cis rs870825 0.616 rs4623060 chr4:185642943 A/G cg04058563 chr4:185651563 MLF1IP 0.65 7.16 0.4 8e-12 Blood protein levels; CESC cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg26597838 chr10:835615 NA 0.87 9.23 0.49 9.18e-18 Eosinophil percentage of granulocytes; CESC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg20887711 chr4:1340912 KIAA1530 0.53 7.32 0.41 2.94e-12 Longevity; CESC cis rs9426691 1 rs9426691 chr1:23484904 A/G cg12483005 chr1:23474871 LUZP1 0.51 7.83 0.43 1.17e-13 Coenzyme Q10 levels; CESC cis rs10242455 0.702 rs28460612 chr7:98993205 C/G cg25640893 chr7:99214727 ZNF498 1.04 6.31 0.36 1.15e-9 Blood metabolite levels; CESC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg02951883 chr7:2050386 MAD1L1 -0.41 -5.35 -0.31 1.88e-7 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10623043 chr11:67211318 CORO1B -0.62 -7.49 -0.42 1.01e-12 Gut microbiome composition (summer); CESC cis rs1577917 1.000 rs12201571 chr6:86609750 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -5.91 -0.34 1.05e-8 Response to antipsychotic treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20340149 chr2:122407145 CLASP1 0.61 7.4 0.41 1.77e-12 Gut microbiome composition (summer); CESC cis rs4604732 0.588 rs12045675 chr1:247623915 C/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.42 5.13 0.3 5.67e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg00149659 chr3:10157352 C3orf10 0.74 8.85 0.48 1.3e-16 Alzheimer's disease; CESC cis rs751728 1.000 rs6920075 chr6:33731797 C/T cg25922239 chr6:33757077 LEMD2 0.52 7.24 0.41 4.84e-12 Crohn's disease; CESC cis rs7216064 0.953 rs4791048 chr17:65848994 G/A cg12091567 chr17:66097778 LOC651250 -0.81 -9.25 -0.49 7.53e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17543123 chr19:30155994 PLEKHF1 -0.43 -6.0 -0.35 6.58e-9 Gut microbiota (bacterial taxa); CESC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg18337363 chr3:52569053 NT5DC2 0.3 5.24 0.31 3.34e-7 Bipolar disorder; CESC cis rs897984 0.683 rs8046001 chr16:30833321 C/T cg02466173 chr16:30829666 NA -0.61 -11.63 -0.58 1.55e-25 Dementia with Lewy bodies; CESC cis rs992157 0.798 rs2382819 chr2:219155909 G/T cg00012203 chr2:219082015 ARPC2 -0.74 -9.58 -0.51 7.54e-19 Colorectal cancer; CESC cis rs11166927 0.548 rs4736099 chr8:140828745 T/C cg16909799 chr8:140841666 TRAPPC9 -0.63 -9.91 -0.52 6.75e-20 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs4242434 0.819 rs2291230 chr8:22463697 C/G cg03733263 chr8:22462867 KIAA1967 0.88 15.37 0.69 1.51e-38 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg09436375 chr6:42928200 GNMT 0.26 5.54 0.32 7.11e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg10691866 chr7:65817282 TPST1 0.32 5.13 0.3 5.51e-7 Aortic root size; CESC cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg19016782 chr12:123741754 C12orf65 0.37 5.43 0.32 1.29e-7 Height;Educational attainment;Head circumference (infant); CESC trans rs57221529 0.709 rs72707023 chr5:667620 G/A cg25482853 chr8:67687455 SGK3 1.03 10.01 0.52 3.23e-20 Lung disease severity in cystic fibrosis; CESC cis rs8114671 0.562 rs1060615 chr20:33478381 C/T cg06115741 chr20:33292138 TP53INP2 -0.48 -5.82 -0.34 1.7e-8 Height; CESC cis rs9300255 0.679 rs4759420 chr12:123794871 G/C cg00376283 chr12:123451042 ABCB9 0.59 6.86 0.39 4.85e-11 Neutrophil percentage of white cells; CESC trans rs7618501 0.602 rs2624853 chr3:50128893 A/G cg21659725 chr3:3221576 CRBN -0.51 -7.04 -0.4 1.67e-11 Intelligence (multi-trait analysis); CESC cis rs7607369 0.596 rs56304256 chr2:219276138 T/C cg02176678 chr2:219576539 TTLL4 -0.41 -6.33 -0.36 1.06e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs73001065 0.591 rs57962361 chr19:19425025 C/T cg03709012 chr19:19516395 GATAD2A 0.92 6.45 0.37 5.41e-10 LDL cholesterol; CESC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg08470875 chr2:26401718 FAM59B -0.73 -7.82 -0.43 1.27e-13 Gut microbiome composition (summer); CESC cis rs67311347 0.955 rs73078170 chr3:40483947 C/T cg09455208 chr3:40491958 NA 0.51 8.08 0.44 2.35e-14 Renal cell carcinoma; CESC cis rs10242455 0.702 rs28668326 chr7:98998153 G/A cg18809830 chr7:99032528 PTCD1 -0.91 -6.3 -0.36 1.22e-9 Blood metabolite levels; CESC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg26335602 chr6:28129616 ZNF389 0.45 6.01 0.35 6.07e-9 Parkinson's disease; CESC cis rs2549003 1.000 rs2070723 chr5:131823187 A/G cg21138405 chr5:131827807 IRF1 0.54 9.17 0.49 1.36e-17 Asthma (sex interaction); CESC cis rs72945132 0.882 rs67093918 chr11:70198999 C/A cg14191688 chr11:70257035 CTTN 0.41 5.12 0.3 6.02e-7 Coronary artery disease; CESC cis rs1005224 0.819 rs10147492 chr14:76155309 T/G cg25116370 chr14:76127843 TTLL5;C14orf1 -0.43 -5.88 -0.34 1.21e-8 Large artery stroke; CESC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg21433313 chr16:3507492 NAT15 -0.61 -6.53 -0.37 3.24e-10 Tuberculosis; CESC cis rs6570726 0.846 rs9399559 chr6:145945778 C/T cg05347473 chr6:146136440 FBXO30 0.53 6.89 0.39 4.01e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7799006 0.606 rs4721527 chr7:2306655 G/A cg12745145 chr7:2261452 MAD1L1 -0.33 -5.24 -0.31 3.21e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs4268898 0.662 rs58971404 chr2:24403753 G/A cg08917208 chr2:24149416 ATAD2B 0.62 5.75 0.33 2.46e-8 Asthma; CESC cis rs71277158 0.688 rs2241292 chr3:169798962 C/G cg04067573 chr3:169899625 PHC3 0.71 6.97 0.39 2.52e-11 Prostate cancer; CESC cis rs4919087 0.683 rs7091162 chr10:99071242 G/T cg25902810 chr10:99078978 FRAT1 -0.5 -5.62 -0.33 4.79e-8 Monocyte count; CESC cis rs1595825 0.891 rs79745588 chr2:198516835 G/A cg10820045 chr2:198174542 NA 0.4 5.04 0.3 8.74e-7 Ulcerative colitis; CESC cis rs7523050 0.643 rs35438081 chr1:109402831 G/T cg08274380 chr1:109419600 GPSM2 0.86 5.69 0.33 3.36e-8 Fat distribution (HIV); CESC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg06456125 chr7:65229604 NA 0.44 5.77 0.33 2.22e-8 Aortic root size; CESC cis rs829883 0.738 rs249854 chr12:98862772 G/A cg25150519 chr12:98850993 NA 0.85 14.18 0.66 2.46e-34 Colorectal adenoma (advanced); CESC cis rs677665 0.537 rs12121476 chr1:9335327 C/G cg25755851 chr1:9335794 NA 0.95 13.99 0.65 1.11e-33 Eosinophil percentage of white cells; CESC cis rs9488822 0.596 rs6568921 chr6:116373616 C/T cg26893134 chr6:116381904 FRK 0.22 5.22 0.31 3.58e-7 Cholesterol, total;LDL cholesterol; CESC cis rs12079745 0.590 rs7544446 chr1:169256524 T/C cg09363564 chr1:169337483 NME7;BLZF1 -0.94 -6.2 -0.36 2.13e-9 QT interval; CESC cis rs2273669 0.667 rs6899723 chr6:109362749 T/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg20503657 chr10:835505 NA 0.76 7.62 0.42 4.63e-13 Eosinophil percentage of granulocytes; CESC cis rs8141529 0.748 rs132533 chr22:29299571 A/G cg15103426 chr22:29168792 CCDC117 -0.6 -7.55 -0.42 7.06e-13 Lymphocyte counts; CESC cis rs9325144 0.560 rs61929893 chr12:38653366 G/A cg26384229 chr12:38710491 ALG10B -0.6 -8.49 -0.46 1.45e-15 Morning vs. evening chronotype; CESC cis rs58688157 0.592 rs12803048 chr11:584243 C/T cg02461776 chr11:598696 PHRF1 0.5 5.39 0.31 1.55e-7 Systemic lupus erythematosus; CESC cis rs1552244 0.882 rs13100734 chr3:10022878 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.18 0.57 4.82e-24 Alzheimer's disease; CESC cis rs9486715 0.867 rs4598081 chr6:96975227 A/G cg06623918 chr6:96969491 KIAA0776 0.96 15.06 0.68 1.84e-37 Headache; CESC cis rs782590 0.818 rs2627782 chr2:55825352 A/G cg18811423 chr2:55921094 PNPT1 0.77 12.1 0.6 4.01e-27 Metabolic syndrome; CESC cis rs597539 0.727 rs632984 chr11:68620271 C/T cg18350739 chr11:68623251 NA -0.46 -6.63 -0.38 1.91e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg15445000 chr17:37608096 MED1 -0.42 -6.65 -0.38 1.69e-10 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg26338869 chr17:61819248 STRADA 0.69 9.12 0.49 1.91e-17 Prudent dietary pattern; CESC cis rs959260 0.748 rs4789178 chr17:73368242 C/G cg12999837 chr17:73267436 MIF4GD -0.47 -5.45 -0.32 1.17e-7 Systemic lupus erythematosus; CESC cis rs9287719 0.967 rs4405729 chr2:10755779 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs10089 0.680 rs3805616 chr5:127520897 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.6 5.32 0.31 2.19e-7 Ileal carcinoids; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17046977 chr15:63796567 USP3 0.56 6.18 0.35 2.41e-9 Gut microbiome composition (summer); CESC trans rs9369898 0.963 rs9381789 chr6:49413391 G/C cg15934674 chr1:150266645 MRPS21 -0.37 -6.03 -0.35 5.37e-9 Homocysteine levels; CESC cis rs4481887 0.927 rs9651176 chr1:248447343 A/G cg00666640 chr1:248458726 OR2T12 0.39 6.67 0.38 1.47e-10 Common traits (Other); CESC cis rs6963495 0.818 rs6956249 chr7:105149743 A/T cg02135003 chr7:105160482 PUS7 -0.47 -5.61 -0.33 5.12e-8 Bipolar disorder (body mass index interaction); CESC cis rs897984 0.542 rs11864806 chr16:31095204 G/C cg02466173 chr16:30829666 NA -0.4 -6.75 -0.38 9.46e-11 Dementia with Lewy bodies; CESC cis rs910316 0.763 rs175047 chr14:75479039 C/G cg11812906 chr14:75593930 NEK9 -0.81 -13.24 -0.63 4.78e-31 Height; CESC cis rs1775715 0.677 rs2808105 chr10:32110907 C/T cg18675610 chr10:32216311 ARHGAP12 0.34 5.27 0.31 2.85e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs733592 0.507 rs7138917 chr12:48455255 G/A cg24011408 chr12:48396354 COL2A1 -0.5 -8.32 -0.45 4.78e-15 Plateletcrit; CESC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg11843238 chr5:131593191 PDLIM4 0.37 5.4 0.31 1.47e-7 Breast cancer; CESC cis rs4233802 1.000 rs10165225 chr2:151121736 C/T cg25300694 chr2:151184358 NA 0.9 7.5 0.42 9.95e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CESC cis rs2425143 0.730 rs6058354 chr20:34491110 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -6.93 -0.39 3.22e-11 Blood protein levels; CESC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.67 -7.53 -0.42 7.92e-13 Gut microbiome composition (summer); CESC cis rs7746199 0.736 rs6904596 chr6:27491299 G/A cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.69 5.18 0.3 4.36e-7 Gait speed in old age;Autism spectrum disorder or schizophrenia; CESC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg11644478 chr21:40555479 PSMG1 -0.84 -12.51 -0.61 1.57e-28 Cognitive function; CESC cis rs12824058 0.799 rs4759656 chr12:130815804 G/A cg26677194 chr12:130822605 PIWIL1 0.52 6.82 0.39 6.23e-11 Menopause (age at onset); CESC cis rs9911578 1.000 rs2531729 chr17:56539890 C/T cg12560992 chr17:57184187 TRIM37 0.92 15.31 0.69 2.4e-38 Intelligence (multi-trait analysis); CESC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg12963246 chr6:28129442 ZNF389 0.51 6.83 0.39 5.78e-11 Parkinson's disease; CESC cis rs666930 0.519 rs483180 chr1:120267505 C/G cg19096424 chr1:120255104 PHGDH -0.72 -8.33 -0.46 4.47e-15 Breast cancer; CESC cis rs6964587 0.626 rs2188841 chr7:91522641 A/G cg17063962 chr7:91808500 NA -0.46 -6.47 -0.37 4.65e-10 Breast cancer; CESC cis rs7598759 0.712 rs6727372 chr2:232331906 T/G cg19187155 chr2:232395269 NMUR1 0.4 6.27 0.36 1.42e-9 Noise-induced hearing loss; CESC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg26314531 chr2:26401878 FAM59B -0.85 -8.88 -0.48 1e-16 Gut microbiome composition (summer); CESC cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11148252 0.574 rs73186430 chr13:53232891 T/C cg00495681 chr13:53174319 NA 0.62 8.55 0.47 9.89e-16 Lewy body disease; CESC cis rs1167827 0.680 rs1167796 chr7:75173180 C/T cg04681579 chr7:75027559 TRIM73;TRIM74 0.47 5.88 0.34 1.21e-8 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1580019 0.587 rs1597555 chr7:32546118 T/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.8 0.76 1.12e-50 Cognitive ability; CESC cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.44 -5.94 -0.34 9.01e-9 Colorectal cancer; CESC cis rs6570726 0.935 rs365658 chr6:145844588 C/T cg23711669 chr6:146136114 FBXO30 0.79 11.85 0.59 2.77e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg18404041 chr3:52824283 ITIH1 0.47 7.78 0.43 1.62e-13 Bipolar disorder; CESC cis rs7605827 0.897 rs11674618 chr2:15593035 T/C cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg24634471 chr8:143751801 JRK -0.45 -5.4 -0.31 1.5e-7 Urinary tract infection frequency; CESC cis rs79057730 0.599 rs9458 chr7:825494 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.85 -7.58 -0.42 5.99e-13 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27223758 chr11:64491106 NRXN2 0.46 6.26 0.36 1.51e-9 Gut microbiome composition (summer); CESC cis rs2742234 0.590 rs2257767 chr10:43657811 T/G cg07801480 chr10:43725741 RASGEF1A 0.46 5.76 0.33 2.3e-8 Hirschsprung disease; CESC cis rs881375 0.678 rs7037195 chr9:123684000 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.45 6.51 0.37 3.65e-10 Rheumatoid arthritis; CESC cis rs8064299 0.597 rs6501736 chr17:72775358 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.87 14.93 0.68 5.45e-37 Monocyte count; CESC cis rs4555082 0.915 rs66527719 chr14:105750523 C/G cg13114125 chr14:105738426 BRF1 -0.74 -9.21 -0.49 1.06e-17 Mean platelet volume;Platelet distribution width; CESC cis rs4132509 0.744 rs12031994 chr1:243917309 T/C cg21452805 chr1:244014465 NA 0.64 7.03 0.4 1.71e-11 RR interval (heart rate); CESC cis rs7342306 0.709 rs4290286 chr12:6290541 A/G cg23019886 chr12:6277045 NA 0.22 5.05 0.3 8.22e-7 Platelet count; CESC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Depression; CESC cis rs2282802 0.685 rs2337138 chr5:139691664 A/C cg26211634 chr5:139558579 C5orf32 0.44 6.32 0.36 1.13e-9 Intelligence (multi-trait analysis); CESC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg13880726 chr7:1868755 MAD1L1 0.51 6.9 0.39 3.91e-11 Bipolar disorder and schizophrenia; CESC cis rs8114671 0.869 rs1407202 chr20:33651967 C/T cg24642439 chr20:33292090 TP53INP2 -0.49 -5.93 -0.34 9.34e-9 Height; CESC cis rs61542988 0.606 rs4722185 chr7:22832711 G/A cg11367502 chr7:22862612 TOMM7 0.54 6.42 0.37 6.29e-10 Fibrinogen levels; CESC cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg27398817 chr8:82754497 SNX16 -0.55 -6.39 -0.37 7.62e-10 Diastolic blood pressure; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08269037 chr1:11751616 MAD2L2;C1orf187 0.49 6.7 0.38 1.27e-10 Gut microbiota (bacterial taxa); CESC cis rs7264396 0.563 rs6058312 chr20:34324484 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.86 0.39 4.77e-11 Total cholesterol levels; CESC cis rs10791097 0.653 rs11222362 chr11:130731425 T/C cg09137382 chr11:130731461 NA 0.39 5.84 0.34 1.51e-8 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs5769765 0.862 rs138897 chr22:50231067 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.47 -5.22 -0.31 3.55e-7 Schizophrenia; CESC cis rs6831352 0.703 rs2602854 chr4:100028651 C/T cg12011299 chr4:100065546 ADH4 0.57 6.87 0.39 4.58e-11 Alcohol dependence; CESC cis rs4253772 0.872 rs4253776 chr22:46629479 C/T cg09491104 chr22:46646882 C22orf40 0.49 6.58 0.37 2.46e-10 LDL cholesterol;Cholesterol, total; CESC cis rs4555082 0.834 rs2735826 chr14:105710866 G/A cg13114125 chr14:105738426 BRF1 -0.81 -9.8 -0.52 1.56e-19 Mean platelet volume;Platelet distribution width; CESC cis rs965469 0.779 rs6051770 chr20:3327014 A/G cg17110299 chr20:3385021 C20orf194 0.4 5.25 0.31 3.1e-7 IFN-related cytopenia; CESC cis rs7582720 1.000 rs72932572 chr2:203859391 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs3780486 0.718 rs73645257 chr9:33132354 C/T cg20290983 chr6:43655470 MRPS18A 0.71 8.4 0.46 2.68e-15 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22209105 chr20:16710841 SNRPB2 0.63 7.02 0.4 1.84e-11 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs4973878 chr3:40407565 C/T cg09455208 chr3:40491958 NA 0.45 7.8 0.43 1.42e-13 Renal cell carcinoma; CESC cis rs77741769 0.571 rs11065283 chr12:121266453 A/G cg02419362 chr12:121203948 SPPL3 0.36 5.79 0.33 2.03e-8 Mean corpuscular volume; CESC cis rs7089973 0.604 rs11196929 chr10:116582080 G/C cg23260525 chr10:116636907 FAM160B1 0.37 6.52 0.37 3.48e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7917772 0.604 rs4917977 chr10:104363119 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 5.66 0.33 4.02e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs710216 0.879 rs710218 chr1:43427218 A/T cg03128534 chr1:43423976 SLC2A1 0.62 7.94 0.44 5.89e-14 Red cell distribution width; CESC cis rs12681288 0.748 rs2701935 chr8:1028618 T/A cg04851639 chr8:1020857 NA -0.42 -8.98 -0.48 5.33e-17 Schizophrenia; CESC cis rs9399135 0.967 rs4895436 chr6:135295001 G/A cg24558204 chr6:135376177 HBS1L 0.5 6.75 0.38 9.09e-11 Red blood cell count; CESC cis rs8017423 0.740 rs8003095 chr14:90680643 A/T cg14092571 chr14:90743983 NA -0.58 -8.73 -0.47 2.97e-16 Mortality in heart failure; CESC cis rs11167764 1.000 rs7722567 chr5:141483178 C/T cg08523384 chr5:141488047 NDFIP1 -0.37 -5.43 -0.32 1.3e-7 Crohn's disease; CESC cis rs6088580 0.634 rs6059896 chr20:33111783 T/C cg06115741 chr20:33292138 TP53INP2 0.45 5.74 0.33 2.53e-8 Glomerular filtration rate (creatinine); CESC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs826838 0.510 rs17523988 chr12:39222785 A/C cg26384229 chr12:38710491 ALG10B 0.7 10.51 0.54 7.69e-22 Heart rate; CESC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg18240062 chr17:79603768 NPLOC4 0.72 10.27 0.53 4.71e-21 Eye color traits; CESC cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 5.96e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6674176 0.569 rs34830883 chr1:44405339 T/C cg23954153 chr1:44402353 ARTN -0.35 -5.51 -0.32 8.39e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7818688 0.929 rs7812312 chr8:96020400 T/C cg16049864 chr8:95962084 TP53INP1 0.61 5.74 0.33 2.56e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs1832871 0.672 rs62437159 chr6:158697705 C/T cg07165851 chr6:158734300 TULP4 0.59 6.32 0.36 1.08e-9 Height; CESC cis rs36051895 0.625 rs11792531 chr9:5152203 T/C cg02405213 chr9:5042618 JAK2 -0.49 -5.55 -0.32 7.04e-8 Pediatric autoimmune diseases; CESC cis rs11792861 0.926 rs58795279 chr9:111851902 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.41 5.09 0.3 6.65e-7 Menarche (age at onset); CESC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg05863683 chr7:1912471 MAD1L1 0.35 5.29 0.31 2.51e-7 Schizophrenia; CESC cis rs12618769 0.625 rs3769717 chr2:99124817 G/A cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs919433 1.000 rs6761919 chr2:198163328 A/G cg10820045 chr2:198174542 NA -0.42 -6.46 -0.37 4.95e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs73001065 0.901 rs3794991 chr19:19610596 C/T cg03709012 chr19:19516395 GATAD2A 0.96 5.93 0.34 9.6e-9 LDL cholesterol; CESC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg20151795 chr6:28129481 ZNF389 0.41 5.3 0.31 2.46e-7 Depression; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25005433 chr10:38146040 ZNF248 -0.41 -6.15 -0.35 2.88e-9 Gambling; CESC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg03452623 chr4:187889614 NA -0.88 -16.16 -0.7 2.28e-41 Lobe attachment (rater-scored or self-reported); CESC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg21747405 chr11:67723411 NA -0.44 -6.72 -0.38 1.12e-10 Blood pressure (smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06728098 chr8:80942046 MRPS28 -0.5 -6.22 -0.36 1.95e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.546 rs1456207 chr4:98676911 G/A cg05340658 chr4:99064831 C4orf37 0.54 6.55 0.37 2.96e-10 Colonoscopy-negative controls vs population controls; CESC trans rs61931739 0.517 rs56308002 chr12:34016021 C/G cg26384229 chr12:38710491 ALG10B 0.59 8.24 0.45 8.19e-15 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25001845 chr14:75201709 FCF1 -0.66 -7.75 -0.43 2e-13 Gut microbiome composition (summer); CESC cis rs6496667 0.779 rs8027211 chr15:90983706 A/G cg13834112 chr15:90361639 NA 0.39 5.07 0.3 7.63e-7 Rheumatoid arthritis; CESC cis rs6834538 0.597 rs9991830 chr4:113485372 T/C cg05166686 chr4:113558556 LARP7;C4orf21 0.43 5.3 0.31 2.43e-7 Free thyroxine concentration; CESC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg12463550 chr7:65579703 CRCP 0.57 7.18 0.4 7.04e-12 Aortic root size; CESC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg27266027 chr21:40555129 PSMG1 0.49 6.01 0.35 6.14e-9 Cognitive function; CESC cis rs365132 0.967 rs353471 chr5:176363429 T/C cg16309518 chr5:176445507 NA -0.37 -5.37 -0.31 1.76e-7 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs4253772 0.513 rs9615345 chr22:46713631 C/T cg24881330 chr22:46731750 TRMU 0.84 8.76 0.47 2.31e-16 LDL cholesterol;Cholesterol, total; CESC cis rs6598955 0.694 rs6659387 chr1:26634307 G/A cg00852783 chr1:26633632 UBXN11 0.43 6.18 0.36 2.35e-9 Obesity-related traits; CESC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg26343298 chr8:95960752 TP53INP1 0.36 5.96 0.34 7.8e-9 Type 2 diabetes; CESC cis rs35110281 0.720 rs162393 chr21:44942692 G/A cg01579765 chr21:45077557 HSF2BP -0.54 -9.19 -0.49 1.15e-17 Mean corpuscular volume; CESC cis rs8017423 0.967 rs11626011 chr14:90693572 A/G cg14092571 chr14:90743983 NA -0.51 -7.61 -0.42 4.78e-13 Mortality in heart failure; CESC cis rs10504229 0.953 rs59034808 chr8:58185337 T/C cg05313129 chr8:58192883 C8orf71 -0.46 -5.71 -0.33 3.1e-8 Developmental language disorder (linguistic errors); CESC cis rs9457247 1.000 rs2149085 chr6:167371110 T/C cg23791538 chr6:167370224 RNASET2 0.61 8.65 0.47 5.15e-16 Crohn's disease; CESC cis rs473651 0.904 rs10929275 chr2:239323169 A/G cg18131467 chr2:239335373 ASB1 1.0 20.02 0.78 6.05e-55 Multiple system atrophy; CESC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg23281280 chr6:28129359 ZNF389 0.6 7.95 0.44 5.53e-14 Depression; CESC cis rs7520050 0.966 rs6661910 chr1:46290632 A/T cg24296786 chr1:45957014 TESK2 0.43 5.4 0.31 1.47e-7 Red blood cell count;Reticulocyte count; CESC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg11663144 chr21:46675770 NA 0.63 9.77 0.51 1.93e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9814567 1.000 rs9809619 chr3:134280948 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.09 -0.35 3.9e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs796364 0.806 rs203766 chr2:200902672 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.87 -8.14 -0.45 1.58e-14 Schizophrenia; CESC cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.79e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1385374 0.858 rs10847696 chr12:129297153 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 0.58 5.22 0.31 3.55e-7 Systemic lupus erythematosus; CESC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg24399712 chr22:39784796 NA -0.81 -10.81 -0.55 8.51e-23 Intelligence (multi-trait analysis); CESC trans rs7618501 0.932 rs4855850 chr3:49761571 G/A cg21659725 chr3:3221576 CRBN -0.83 -13.7 -0.64 1.17e-32 Intelligence (multi-trait analysis); CESC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg03188948 chr7:1209495 NA 0.72 6.98 0.39 2.42e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2658782 0.789 rs2605574 chr11:93136444 T/G cg15737290 chr11:93063684 CCDC67 0.4 5.25 0.31 3.12e-7 Pulmonary function decline; CESC trans rs10751667 1.000 rs6597972 chr11:928402 C/T cg11748187 chr10:114713108 TCF7L2 -0.4 -6.15 -0.35 2.88e-9 Alzheimer's disease (late onset); CESC cis rs9457247 0.529 rs6907666 chr6:167523395 A/G cg23791538 chr6:167370224 RNASET2 0.46 6.11 0.35 3.46e-9 Crohn's disease; CESC cis rs6088580 0.634 rs6120642 chr20:33012531 A/G cg08999081 chr20:33150536 PIGU 0.65 11.43 0.57 7.26e-25 Glomerular filtration rate (creatinine); CESC cis rs11690935 0.959 rs10184866 chr2:172608956 T/G cg13550731 chr2:172543902 DYNC1I2 -1.02 -16.95 -0.72 3.78e-44 Schizophrenia; CESC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg27121462 chr16:89883253 FANCA -0.47 -5.52 -0.32 8.24e-8 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20851790 chr17:78330477 RNF213;LOC100294362 -0.61 -7.71 -0.43 2.55e-13 Gut microbiome composition (summer); CESC cis rs798766 1.000 rs798766 chr4:1734239 C/T cg05874882 chr4:1763078 NA 0.57 7.64 0.42 3.99e-13 Bladder cancer;Urinary bladder cancer; CESC cis rs4722166 0.630 rs2091115 chr7:22810166 G/T cg26061582 chr7:22766209 IL6 0.53 6.11 0.35 3.58e-9 Lung cancer; CESC cis rs9457247 0.663 rs9459835 chr6:167417551 G/T cg23791538 chr6:167370224 RNASET2 -0.58 -7.96 -0.44 5.09e-14 Crohn's disease; CESC cis rs10170846 0.893 rs11692810 chr2:223544096 A/C cg25565276 chr2:223520875 FARSB -0.57 -7.96 -0.44 4.98e-14 Schizophrenia (inflammation and infection response interaction); CESC cis rs6087990 0.899 rs6058893 chr20:31392777 C/T cg13636640 chr20:31349939 DNMT3B 0.88 15.22 0.68 5.13e-38 Ulcerative colitis; CESC cis rs7607369 0.536 rs6436091 chr2:219669141 T/C cg02176678 chr2:219576539 TTLL4 -0.36 -6.16 -0.35 2.75e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg11644478 chr21:40555479 PSMG1 -0.55 -7.46 -0.42 1.24e-12 Menarche (age at onset); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11956111 chr2:74710460 TTC31;CCDC142 0.5 6.74 0.38 9.6e-11 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09730017 chr11:118955708 HMBS -0.66 -7.54 -0.42 7.65e-13 Gut microbiome composition (summer); CESC cis rs2295499 0.727 rs9762293 chr4:2729158 C/G cg08330972 chr4:2403930 ZFYVE28 -0.31 -5.04 -0.3 8.52e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04686114 chr12:57081832 PTGES3 0.54 6.58 0.37 2.53e-10 Gut microbiome composition (summer); CESC cis rs9863 0.861 rs3789967 chr12:124447339 T/G cg17562584 chr12:124393655 DNAH10 0.32 5.55 0.32 6.96e-8 White blood cell count; CESC cis rs3540 0.512 rs3862433 chr15:91076028 G/A cg22089800 chr15:90895588 ZNF774 -0.64 -8.73 -0.47 2.85e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9611565 0.546 rs739134 chr22:42089623 T/C cg06481639 chr22:41940642 POLR3H 0.62 6.5 0.37 3.95e-10 Vitiligo; CESC cis rs3540 0.576 rs12907587 chr15:91045851 G/C cg22089800 chr15:90895588 ZNF774 -0.65 -8.94 -0.48 6.86e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs397969 0.607 rs169413 chr17:19849745 G/A cg12073167 chr17:19770448 ULK2 -0.44 -5.11 -0.3 6.17e-7 Platelet count; CESC cis rs7267979 1.000 rs448396 chr20:25440269 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.57 0.73 2.33e-46 Liver enzyme levels (alkaline phosphatase); CESC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg17143192 chr8:8559678 CLDN23 -0.6 -6.53 -0.37 3.37e-10 Obesity-related traits; CESC cis rs9611565 0.525 rs1883827 chr22:41703579 A/G cg06481639 chr22:41940642 POLR3H -0.49 -5.57 -0.32 6.21e-8 Vitiligo; CESC trans rs7945705 0.935 rs2568061 chr11:8886260 A/G cg10637292 chr12:52960529 KRT74 0.36 6.19 0.36 2.27e-9 Hemoglobin concentration; CESC cis rs12079745 1.000 rs72637225 chr1:169129320 T/G cg09363564 chr1:169337483 NME7;BLZF1 -0.71 -5.47 -0.32 1.06e-7 QT interval; CESC cis rs9300255 0.602 rs1727314 chr12:123640664 C/A cg19016782 chr12:123741754 C12orf65 -0.4 -5.77 -0.33 2.27e-8 Neutrophil percentage of white cells; CESC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg21963583 chr11:68658836 MRPL21 0.38 5.11 0.3 6.19e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg27170947 chr2:26402098 FAM59B 0.66 7.37 0.41 2.12e-12 Gut microbiome composition (summer); CESC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg07701084 chr6:150067640 NUP43 0.41 5.73 0.33 2.67e-8 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24441383 chr12:19459574 PLEKHA5 0.53 6.93 0.39 3.25e-11 Fibrinogen levels; CESC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg09877947 chr5:131593287 PDLIM4 0.48 6.32 0.36 1.11e-9 Acylcarnitine levels; CESC cis rs4150161 0.591 rs3785036 chr16:84219810 T/G cg10106505 chr16:84220380 TAF1C -0.76 -5.53 -0.32 7.76e-8 Systolic blood pressure response to hydrochlorothiazide in hypertension; CESC trans rs11039798 0.925 rs6485831 chr11:48455031 A/T cg15704280 chr7:45808275 SEPT13 0.68 6.37 0.36 8.22e-10 Axial length; CESC cis rs17655565 0.508 rs1548303 chr12:52737642 C/T cg00777198 chr12:52828273 KRT75 0.37 5.48 0.32 9.85e-8 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg12034118 chr1:209979487 IRF6 0.42 5.31 0.31 2.37e-7 Cleft lip with or without cleft palate; CESC cis rs7116495 0.881 rs7930722 chr11:71737484 C/G cg26138937 chr11:71823887 C11orf51 -0.77 -6.19 -0.36 2.3e-9 Severe influenza A (H1N1) infection; CESC cis rs7255436 0.928 rs7250870 chr19:8453682 C/T cg10174797 chr19:8464628 RAB11B 0.39 5.55 0.32 7.06e-8 HDL cholesterol; CESC cis rs2832191 0.791 rs8134407 chr21:30476586 G/A cg08807101 chr21:30365312 RNF160 0.74 10.56 0.54 5.33e-22 Dental caries; CESC trans rs561341 0.941 rs2470236 chr17:30304940 G/C cg20587970 chr11:113659929 NA -1.1 -13.93 -0.65 1.88e-33 Hip circumference adjusted for BMI; CESC cis rs854765 0.647 rs854770 chr17:18019048 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.25 0.36 1.65e-9 Total body bone mineral density; CESC trans rs7618501 0.633 rs11925192 chr3:50038664 G/A cg21659725 chr3:3221576 CRBN 0.49 6.89 0.39 3.95e-11 Intelligence (multi-trait analysis); CESC trans rs6828577 0.819 rs1064034 chr4:119631992 A/T cg05098011 chr1:151736092 OAZ3;MRPL9 0.49 6.13 0.35 3.25e-9 Perioperative myocardial infarction in coronary artery bypass surgery; CESC cis rs13343954 0.518 rs2216594 chr19:33533258 G/A cg03563238 chr19:33554763 RHPN2 -0.31 -5.44 -0.32 1.21e-7 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15739997 chr20:48729771 UBE2V1;TMEM189-UBE2V1 0.58 6.24 0.36 1.75e-9 Gut microbiome composition (summer); CESC cis rs8044868 0.586 rs6499564 chr16:72189655 G/A cg01557791 chr16:72042693 DHODH -0.41 -5.47 -0.32 1.02e-7 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs2243480 1.000 rs4718333 chr7:65772758 T/C cg18252515 chr7:66147081 NA 1.41 14.3 0.66 9.43e-35 Diabetic kidney disease; CESC cis rs11711311 0.955 rs9823423 chr3:113419741 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.57 7.51 0.42 9.29e-13 IgG glycosylation; CESC cis rs2072732 0.861 rs67289919 chr1:2954208 G/A cg03976712 chr1:2946727 NA 0.33 5.53 0.32 7.83e-8 Plateletcrit; CESC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg13628971 chr7:2884303 GNA12 -0.61 -7.84 -0.43 1.07e-13 Height; CESC cis rs7580658 0.929 rs2276583 chr2:128014684 G/A cg10021288 chr2:128175891 PROC -0.41 -6.47 -0.37 4.79e-10 Protein C levels; CESC cis rs11098499 0.775 rs67281037 chr4:120281157 G/C cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs3126085 0.935 rs4634913 chr1:152249932 T/C cg03465714 chr1:152285911 FLG -0.46 -5.75 -0.33 2.42e-8 Atopic dermatitis; CESC cis rs9914988 0.943 rs12453504 chr17:27119524 C/A cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs1371867 0.875 rs7830342 chr8:101327738 T/A cg11906718 chr8:101322791 RNF19A 0.46 5.92 0.34 1.02e-8 Atrioventricular conduction; CESC cis rs8050907 0.744 rs78538387 chr16:4523167 G/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.9 6.28 0.36 1.39e-9 Obesity-related traits; CESC cis rs597583 0.715 rs11216437 chr11:117394685 A/G cg27161313 chr11:117392002 DSCAML1 0.46 6.03 0.35 5.46e-9 Putamen volume; CESC cis rs11792861 0.589 rs75742991 chr9:111929624 C/G cg13535736 chr9:111863775 C9orf5 -0.5 -6.15 -0.35 2.89e-9 Menarche (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03161587 chr2:220405163 CHPF 0.47 7.12 0.4 1.02e-11 Gambling; CESC cis rs644799 1.000 rs623191 chr11:95548359 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9911578 1.000 rs12449365 chr17:56600660 C/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.53 -0.32 7.63e-8 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02327464 chr16:88871102 CDT1 0.56 6.37 0.36 8.28e-10 Gut microbiome composition (summer); CESC cis rs10206020 0.836 rs10202105 chr2:1553301 C/T cg26248373 chr2:1572462 NA -0.55 -6.12 -0.35 3.31e-9 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09038155 chr4:139937227 CCRN4L 0.55 6.04 0.35 5.29e-9 Gut microbiome composition (summer); CESC cis rs714031 0.785 rs11704439 chr22:40069493 T/G cg21377881 chr22:40064566 CACNA1I -0.37 -6.03 -0.35 5.62e-9 Schizophrenia; CESC cis rs66731853 0.769 rs657624 chr1:20888348 C/T cg04087271 chr1:20915334 CDA -0.45 -6.28 -0.36 1.38e-9 Mean corpuscular volume; CESC cis rs4595586 0.546 rs2056159 chr12:39270417 C/G cg26384229 chr12:38710491 ALG10B 0.69 10.4 0.54 1.82e-21 Morning vs. evening chronotype; CESC cis rs3091242 0.933 rs10903130 chr1:25769221 A/T cg02931644 chr1:25747376 RHCE 0.39 6.6 0.38 2.19e-10 Erythrocyte sedimentation rate; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02698620 chr7:45026579 C7orf40;SNORA9 0.51 6.57 0.37 2.68e-10 Gut microbiota (bacterial taxa); CESC cis rs6460942 1.000 rs77010200 chr7:12290724 G/A cg10578991 chr7:12443926 VWDE -0.56 -5.76 -0.33 2.27e-8 Coronary artery disease; CESC cis rs10754283 0.967 rs10754285 chr1:90116587 A/G cg21401794 chr1:90099060 LRRC8C 0.54 7.2 0.4 6.35e-12 Amyotrophic lateral sclerosis (sporadic); CESC cis rs7666738 0.581 rs34205844 chr4:98887494 C/A cg05340658 chr4:99064831 C4orf37 0.71 10.09 0.53 1.79e-20 Colonoscopy-negative controls vs population controls; CESC trans rs79976124 0.800 rs10944857 chr6:66637078 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 7.73 0.43 2.2e-13 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06397510 chr1:32403634 PTP4A2 0.57 6.79 0.38 7.4e-11 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg27170947 chr2:26402098 FAM59B 0.87 9.89 0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs6665290 0.935 rs12403236 chr1:227196502 C/G cg10327440 chr1:227177885 CDC42BPA -1.23 -31.46 -0.89 1.89e-91 Myeloid white cell count; CESC cis rs2120019 1.000 rs2415253 chr15:75375699 A/G cg17294928 chr15:75287854 SCAMP5 -0.6 -6.81 -0.39 6.44e-11 Blood trace element (Zn levels); CESC trans rs9929218 0.817 rs3114402 chr16:68719607 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.84 -11.16 -0.57 5.74e-24 Colorectal cancer; CESC cis rs3540 0.597 rs7498113 chr15:91051192 C/G cg22089800 chr15:90895588 ZNF774 -0.63 -8.41 -0.46 2.65e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg08888203 chr3:10149979 C3orf24 0.49 6.14 0.35 3.07e-9 Alzheimer's disease; CESC cis rs4919087 0.748 rs701816 chr10:98977250 C/T cg25902810 chr10:99078978 FRAT1 -0.51 -5.73 -0.33 2.66e-8 Monocyte count; CESC cis rs9291683 0.595 rs35250962 chr4:10048271 C/T cg02734326 chr4:10020555 SLC2A9 0.47 6.6 0.38 2.23e-10 Bone mineral density; CESC cis rs6032067 1.000 rs6032052 chr20:43829883 C/A cg10761708 chr20:43804764 PI3 0.52 6.32 0.36 1.07e-9 Blood protein levels; CESC cis rs9640161 0.830 rs76741564 chr7:150059529 A/T cg17279839 chr7:150038598 RARRES2 0.41 5.33 0.31 2.07e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs453301 0.658 rs6983877 chr8:8904639 T/C cg15556689 chr8:8085844 FLJ10661 -0.51 -6.27 -0.36 1.47e-9 Joint mobility (Beighton score); CESC cis rs7666738 0.546 rs13105521 chr4:98734419 C/T cg05340658 chr4:99064831 C4orf37 0.58 7.22 0.41 5.63e-12 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.861 rs8079590 chr17:37426201 T/C cg07936489 chr17:37558343 FBXL20 -0.8 -11.48 -0.58 5.11e-25 Glomerular filtration rate (creatinine); CESC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg04166393 chr7:2884313 GNA12 0.62 8.1 0.45 2.08e-14 Height; CESC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg06481639 chr22:41940642 POLR3H 0.64 6.52 0.37 3.61e-10 Vitiligo; CESC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg05564831 chr3:52568323 NT5DC2 0.44 6.68 0.38 1.37e-10 Bipolar disorder; CESC cis rs1044826 0.642 rs4607068 chr3:139162994 A/G cg00490450 chr3:139108681 COPB2 0.41 5.05 0.3 8.21e-7 Obesity-related traits; CESC cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg20503657 chr10:835505 NA 0.79 7.89 0.44 8.13e-14 Eosinophil percentage of granulocytes; CESC cis rs67311347 1.000 rs9882171 chr3:40518821 G/A cg24209194 chr3:40518798 ZNF619 0.57 7.75 0.43 2.03e-13 Renal cell carcinoma; CESC cis rs9911578 0.842 rs12450766 chr17:56832965 G/C cg05425664 chr17:57184151 TRIM37 0.46 5.73 0.33 2.72e-8 Intelligence (multi-trait analysis); CESC cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg22875332 chr1:76189707 ACADM 0.7 9.5 0.5 1.27e-18 Blood metabolite levels;Acylcarnitine levels; CESC trans rs12599106 0.715 rs34006830 chr16:34878550 C/A cg11235426 chr6:292522 DUSP22 -0.72 -9.09 -0.49 2.39e-17 Menopause (age at onset); CESC cis rs7216064 1.000 rs3206817 chr17:65892834 A/G cg07042672 chr17:66097459 LOC651250 -0.54 -5.81 -0.34 1.79e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02217955 chr22:50941799 LMF2 0.43 6.8 0.39 6.91e-11 Fibrinogen levels; CESC cis rs9549260 0.753 rs9549246 chr13:41220755 G/A cg21288729 chr13:41239152 FOXO1 0.53 5.04 0.3 8.53e-7 Red blood cell count; CESC cis rs4704187 0.553 rs116188801 chr5:74398141 A/G cg03227963 chr5:74354835 NA 0.32 5.91 0.34 1.03e-8 Response to amphetamines; CESC trans rs116095464 0.614 rs10059220 chr5:242813 C/T cg00938859 chr5:1591904 SDHAP3 0.7 6.66 0.38 1.54e-10 Breast cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26782824 chr11:82867961 PCF11 0.43 6.0 0.35 6.29e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs72781680 0.898 rs55846516 chr2:24158003 T/C cg08917208 chr2:24149416 ATAD2B 0.94 8.66 0.47 4.66e-16 Lymphocyte counts; CESC cis rs6433857 0.594 rs17455575 chr2:181524487 G/A cg23363182 chr2:181467187 NA -0.47 -6.56 -0.37 2.78e-10 Body mass index; CESC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs2576037 0.526 rs564113 chr18:44364389 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.42 6.89 0.39 4.17e-11 Personality dimensions; CESC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 22.16 0.81 2.75e-62 Prudent dietary pattern; CESC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg18876405 chr7:65276391 NA 0.54 7.27 0.41 3.98e-12 Aortic root size; CESC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg00149659 chr3:10157352 C3orf10 -0.7 -9.07 -0.49 2.76e-17 Alzheimer's disease; CESC cis rs597539 0.690 rs11228383 chr11:68623228 T/G cg04772025 chr11:68637568 NA 0.53 5.95 0.34 8.3e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg24562669 chr7:97807699 LMTK2 0.5 7.25 0.41 4.62e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs7818345 0.845 rs7821446 chr8:19268822 A/G cg11303988 chr8:19266685 CSGALNACT1 -0.39 -6.92 -0.39 3.4e-11 Language performance in older adults (adjusted for episodic memory); CESC cis rs34779708 0.966 rs6481941 chr10:35440141 G/A cg04310649 chr10:35416472 CREM -0.54 -6.57 -0.37 2.61e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs3857067 1.000 rs1588382 chr4:95017589 C/T cg11021082 chr4:95130006 SMARCAD1 -0.52 -7.99 -0.44 4.12e-14 QT interval; CESC cis rs910316 0.967 rs11159116 chr14:75550584 G/T cg08847533 chr14:75593920 NEK9 1.0 18.73 0.75 1.97e-50 Height; CESC cis rs3749237 0.595 rs1568661 chr3:49520958 A/G cg02487422 chr3:49467188 NICN1 0.57 8.17 0.45 1.23e-14 Resting heart rate; CESC cis rs9303280 0.806 rs10852936 chr17:38031714 C/T cg20243544 chr17:37824526 PNMT 0.49 6.31 0.36 1.15e-9 Self-reported allergy; CESC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg06481639 chr22:41940642 POLR3H 0.6 5.92 0.34 9.88e-9 Vitiligo; CESC trans rs561341 0.739 rs6505267 chr17:30225950 A/C cg20587970 chr11:113659929 NA -0.62 -7.94 -0.44 5.93e-14 Hip circumference adjusted for BMI; CESC trans rs7937682 0.883 rs659529 chr11:111436896 T/A cg18187862 chr3:45730750 SACM1L 0.57 7.18 0.4 7.14e-12 Primary sclerosing cholangitis; CESC cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg00701064 chr4:6280414 WFS1 0.7 11.8 0.59 4.03e-26 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4704187 0.687 rs1363579 chr5:74510353 G/T cg03227963 chr5:74354835 NA 0.28 5.04 0.3 8.66e-7 Response to amphetamines; CESC cis rs4132509 0.779 rs3006936 chr1:243674772 A/G cg21452805 chr1:244014465 NA 0.42 5.17 0.3 4.58e-7 RR interval (heart rate); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04534504 chr10:62704143 RHOBTB1 -0.44 -6.08 -0.35 4.13e-9 Fibrinogen levels; CESC cis rs7481584 0.624 rs440130 chr11:3051476 A/G cg25174290 chr11:3078921 CARS -0.45 -6.27 -0.36 1.48e-9 Calcium levels; CESC cis rs9486719 0.948 rs11152952 chr6:96894303 A/G cg18709589 chr6:96969512 KIAA0776 -0.53 -5.81 -0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs10089 1.000 rs4836363 chr5:127462737 G/C cg19767477 chr5:127420684 SLC12A2 -0.4 -5.32 -0.31 2.18e-7 Ileal carcinoids; CESC cis rs12476592 0.602 rs7576316 chr2:63741122 G/A cg17519650 chr2:63277830 OTX1 -0.48 -5.55 -0.32 6.83e-8 Childhood ear infection; CESC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg23161317 chr6:28129485 ZNF389 0.47 5.88 0.34 1.21e-8 Depression; CESC trans rs877282 0.898 rs11253350 chr10:765968 G/A cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.04 -0.4 1.68e-11 Personality dimensions; CESC cis rs9911578 1.000 rs2643119 chr17:56827760 G/T cg05425664 chr17:57184151 TRIM37 -0.49 -6.72 -0.38 1.11e-10 Intelligence (multi-trait analysis); CESC cis rs4474465 0.646 rs10751297 chr11:78278567 C/T cg27205649 chr11:78285834 NARS2 0.49 6.42 0.37 6.14e-10 Alzheimer's disease (survival time); CESC cis rs7918232 0.830 rs7911024 chr10:27433636 A/C cg14240646 chr10:27532245 ACBD5 -0.68 -6.49 -0.37 4.12e-10 Breast cancer; CESC cis rs2882667 0.858 rs11951899 chr5:138374310 A/G cg04439458 chr5:138467593 SIL1 -0.42 -6.47 -0.37 4.7e-10 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7635838 0.827 rs9826044 chr3:11458075 A/G cg00170343 chr3:11313890 ATG7 0.43 5.73 0.33 2.72e-8 HDL cholesterol; CESC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg06494592 chr3:125709126 NA -0.44 -5.05 -0.3 8.41e-7 Blood pressure (smoking interaction); CESC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC cis rs4704187 0.687 rs1363577 chr5:74463185 T/G cg03227963 chr5:74354835 NA 0.29 5.32 0.31 2.25e-7 Response to amphetamines; CESC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.89 0.39 4.03e-11 Bipolar disorder; CESC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.49 -6.25 -0.36 1.62e-9 Total body bone mineral density; CESC cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC cis rs2282802 0.758 rs739954 chr5:139701920 C/T cg26211634 chr5:139558579 C5orf32 0.36 5.23 0.31 3.51e-7 Intelligence (multi-trait analysis); CESC cis rs13191362 0.935 rs34603926 chr6:163266793 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.69 6.41 0.37 6.47e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg12564285 chr5:131593104 PDLIM4 0.36 5.15 0.3 5.01e-7 Blood metabolite levels; CESC cis rs7084402 0.967 rs1658468 chr10:60292664 A/G cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg18230493 chr5:56204884 C5orf35 -0.72 -8.39 -0.46 2.96e-15 Initial pursuit acceleration; CESC cis rs7188697 0.922 rs9924805 chr16:58615659 T/C cg21335942 chr16:58549945 SETD6 -0.45 -5.24 -0.31 3.34e-7 QT interval; CESC cis rs7772486 0.875 rs7739418 chr6:146359188 G/A cg05347473 chr6:146136440 FBXO30 0.48 6.5 0.37 4.02e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1707322 0.721 rs6429574 chr1:46134054 A/G cg06784218 chr1:46089804 CCDC17 0.41 7.41 0.41 1.67e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9303401 0.659 rs11495824 chr17:56918882 C/A cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.45 0.61 2.57e-28 Cognitive test performance; CESC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg24531977 chr5:56204891 C5orf35 0.45 5.4 0.31 1.47e-7 Coronary artery disease; CESC cis rs262150 0.567 rs2527177 chr7:158804737 T/C cg19418458 chr7:158789849 NA -0.42 -6.36 -0.36 8.92e-10 Facial morphology (factor 20); CESC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg05564831 chr3:52568323 NT5DC2 0.48 7.73 0.43 2.18e-13 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15421363 chr5:131826865 IRF1 0.53 6.34 0.36 9.96e-10 Gut microbiome composition (summer); CESC cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg14393609 chr7:65229607 NA 0.44 5.66 0.33 3.88e-8 Aortic root size; CESC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg25036284 chr2:26402008 FAM59B -0.58 -6.53 -0.37 3.26e-10 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg11663144 chr21:46675770 NA -0.63 -10.04 -0.53 2.57e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7520050 0.966 rs12409773 chr1:46358831 A/G cg24296786 chr1:45957014 TESK2 0.42 5.26 0.31 2.92e-7 Red blood cell count;Reticulocyte count; CESC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg10862848 chr6:42927986 GNMT -0.3 -7.47 -0.42 1.14e-12 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9354352 0.935 rs7766730 chr6:66697003 C/A cg07460842 chr6:66804631 NA 0.66 9.67 0.51 3.82e-19 Initial pursuit acceleration in psychotic disorders; CESC cis rs9513593 1.000 rs723090 chr13:100017105 A/G cg21788972 chr13:99853209 UBAC2 0.62 7.01 0.4 1.93e-11 Psoriasis; CESC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg07507251 chr3:52567010 NT5DC2 0.41 7.2 0.4 6.34e-12 Bipolar disorder; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg13030586 chr4:186347098 UFSP2 -0.43 -6.08 -0.35 4.28e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg21280719 chr6:42927975 GNMT -0.3 -6.8 -0.39 7.12e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg13607699 chr17:42295918 UBTF -0.82 -12.74 -0.62 2.52e-29 Total body bone mineral density; CESC cis rs12079745 0.590 rs10919100 chr1:169190401 C/T cg09363564 chr1:169337483 NME7;BLZF1 -1.1 -6.51 -0.37 3.77e-10 QT interval; CESC cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg24110177 chr3:50126178 RBM5 -0.51 -7.1 -0.4 1.16e-11 Intelligence (multi-trait analysis); CESC cis rs2073300 0.609 rs6137907 chr20:23344511 C/T cg16736954 chr20:23401023 NAPB 0.77 5.74 0.33 2.6e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg27132391 chr11:6341850 PRKCDBP 0.48 6.18 0.35 2.4e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1790761 0.587 rs4930430 chr11:67294198 A/G cg00290607 chr11:67383545 NA 0.4 5.95 0.34 8.6e-9 Mean corpuscular volume; CESC cis rs4523957 0.583 rs9303251 chr17:2047214 C/T cg16513277 chr17:2031491 SMG6 -0.75 -10.79 -0.55 9.49e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7786808 0.707 rs11770299 chr7:158228822 G/A cg01191920 chr7:158217561 PTPRN2 -0.45 -8.07 -0.44 2.4e-14 Obesity-related traits; CESC cis rs684232 0.563 rs12939528 chr17:524391 C/T cg12384639 chr17:618140 VPS53 0.42 5.42 0.32 1.32e-7 Prostate cancer; CESC cis rs4919087 0.620 rs1253427 chr10:98981092 G/A cg25902810 chr10:99078978 FRAT1 -0.53 -5.2 -0.3 3.98e-7 Monocyte count; CESC cis rs9303401 0.614 rs34678056 chr17:57177549 G/A cg25039879 chr17:56429692 SUPT4H1 0.5 5.29 0.31 2.58e-7 Cognitive test performance; CESC cis rs9796 0.505 rs28665387 chr15:41532869 G/T cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.43 -0.37 5.82e-10 Menopause (age at onset); CESC cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 -0.5 -6.58 -0.37 2.51e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10883723 0.773 rs2296578 chr10:104240974 C/G ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.22 0.31 3.57e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg19077165 chr18:44547161 KATNAL2 -0.53 -7.83 -0.43 1.17e-13 Personality dimensions; CESC cis rs796364 1.000 rs769950 chr2:200730028 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 8.19 0.45 1.12e-14 Schizophrenia; CESC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.93 12.29 0.6 9.2e-28 IgG glycosylation; CESC cis rs2242073 0.660 rs4289171 chr2:209000144 G/A cg10392614 chr2:208977121 NA -0.38 -5.12 -0.3 5.92e-7 Attention deficit hyperactivity disorder; CESC cis rs11098499 0.863 rs2127823 chr4:120485670 G/T cg09307838 chr4:120376055 NA 0.9 12.2 0.6 1.77e-27 Corneal astigmatism; CESC cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg22875332 chr1:76189707 ACADM 0.65 7.61 0.42 4.8e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3806843 0.900 rs2563279 chr5:140131535 G/A cg26395211 chr5:140044315 WDR55 0.4 5.16 0.3 4.86e-7 Depressive symptoms (multi-trait analysis); CESC cis rs28830936 0.510 rs7174099 chr15:42099059 A/G cg17847044 chr15:42102381 MAPKBP1 -0.46 -8.18 -0.45 1.23e-14 Diastolic blood pressure; CESC cis rs10129255 0.536 rs6576223 chr14:107184687 C/T cg07958169 chr14:107095056 NA -0.54 -8.51 -0.46 1.33e-15 Kawasaki disease; CESC cis rs36051895 0.632 rs1590803 chr9:5177533 T/C cg02405213 chr9:5042618 JAK2 -0.51 -6.62 -0.38 2.03e-10 Pediatric autoimmune diseases; CESC cis rs4073582 0.595 rs1151540 chr11:66041807 A/C cg14036092 chr11:66035641 RAB1B 0.56 7.89 0.44 8.15e-14 Gout; CESC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg08470875 chr2:26401718 FAM59B -0.46 -5.14 -0.3 5.45e-7 Gut microbiome composition (summer); CESC cis rs854765 0.583 rs28428991 chr17:17827649 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.18 0.45 1.22e-14 Total body bone mineral density; CESC cis rs9926296 0.712 rs258330 chr16:89729574 T/G cg03605463 chr16:89740564 NA 0.64 7.82 0.43 1.3e-13 Vitiligo; CESC cis rs2228479 0.717 rs62052210 chr16:89980158 A/G cg00800038 chr16:89945340 TCF25 -0.75 -7.09 -0.4 1.23e-11 Skin colour saturation; CESC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs2228479 0.850 rs17226498 chr16:89840631 T/C cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg16757658 chr11:126138769 SRPR;FOXRED1 -0.49 -6.59 -0.38 2.37e-10 Ulcerative colitis; CESC cis rs7264396 0.747 rs73283043 chr20:34383863 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -11.45 -0.58 6.33e-25 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17106536 chr1:227127636 CABC1 0.6 6.6 0.38 2.29e-10 Gut microbiome composition (summer); CESC cis rs6893300 0.785 rs55654737 chr5:179218842 G/A cg14593053 chr5:179126677 CANX -0.5 -5.89 -0.34 1.15e-8 Resting heart rate; CESC cis rs17854409 0.803 rs1048109 chr20:61472120 G/A cg05147244 chr20:61493195 TCFL5 0.97 6.5 0.37 4e-10 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15084921 chr5:14143207 TRIO 0.55 6.16 0.35 2.71e-9 Gut microbiome composition (summer); CESC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.75 -0.38 9.05e-11 Electroencephalogram traits; CESC trans rs2832077 0.527 rs2705690 chr21:30239245 T/A cg14791747 chr16:20752902 THUMPD1 -0.48 -6.53 -0.37 3.26e-10 Cognitive test performance; CESC cis rs796364 0.789 rs176008 chr2:200814720 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.87 8.5 0.46 1.36e-15 Schizophrenia; CESC cis rs9457247 1.000 rs436707 chr6:167388843 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg12463550 chr7:65579703 CRCP -0.49 -6.21 -0.36 2.06e-9 Aortic root size; CESC cis rs1957429 0.614 rs61012404 chr14:65347649 C/T cg23373153 chr14:65346875 NA -0.9 -6.61 -0.38 2.11e-10 Pediatric areal bone mineral density (radius); CESC cis rs3008870 1.000 rs1137656 chr1:67451602 A/C cg08660285 chr1:67390436 MIER1;WDR78 -1.06 -15.19 -0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs1670533 1.000 rs13134921 chr4:1054177 A/G cg27284194 chr4:1044797 NA 0.46 5.8 0.34 1.84e-8 Recombination rate (females); CESC cis rs6570726 0.935 rs371744 chr6:145841024 C/T cg05347473 chr6:146136440 FBXO30 0.44 6.04 0.35 5.25e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs3820068 0.705 rs2042369 chr1:15843244 A/G cg18192808 chr1:15853278 DNAJC16 -0.46 -5.62 -0.33 4.85e-8 Systolic blood pressure; CESC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.94 -0.56 3.04e-23 Alzheimer's disease; CESC cis rs7828089 0.582 rs3817445 chr8:22266054 G/T cg12081754 chr8:22256438 SLC39A14 0.62 8.67 0.47 4.54e-16 Verbal declarative memory; CESC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.79 0.34 2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9470366 0.545 rs6930083 chr6:36634156 A/G cg08179530 chr6:36648295 CDKN1A -0.58 -8.26 -0.45 7.05e-15 QRS duration; CESC cis rs68170813 0.641 rs79328953 chr7:106901557 C/T cg02696742 chr7:106810147 HBP1 -0.53 -5.13 -0.3 5.74e-7 Coronary artery disease; CESC cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.8 8.16 0.45 1.39e-14 Schizophrenia; CESC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg27535305 chr1:53392650 SCP2 -0.32 -5.32 -0.31 2.25e-7 Monocyte count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19138900 chr10:3826266 KLF6 0.43 6.01 0.35 5.99e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01915076 chr12:49393228 DDN 0.54 6.32 0.36 1.12e-9 Gut microbiome composition (summer); CESC trans rs9784649 0.760 rs72755820 chr5:25066181 G/A cg08600765 chr20:34638493 LOC647979 -0.55 -6.24 -0.36 1.69e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs72945132 0.882 rs6592537 chr11:70172975 C/T cg00319359 chr11:70116639 PPFIA1 0.76 7.4 0.41 1.86e-12 Coronary artery disease; CESC cis rs9733 0.744 rs12126004 chr1:150889877 T/C cg22823121 chr1:150693482 HORMAD1 -0.35 -5.04 -0.3 8.72e-7 Tonsillectomy; CESC cis rs3091242 0.902 rs36003018 chr1:25784318 A/G cg12412775 chr1:25698385 RHCE 0.28 5.11 0.3 6.04e-7 Erythrocyte sedimentation rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T ch.14.1513839R chr14:93819181 KIAA1409 -0.59 -6.6 -0.38 2.23e-10 Gut microbiome composition (summer); CESC cis rs75477785 0.590 rs17015565 chr1:210244688 A/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.92 6.23 0.36 1.82e-9 Cleft lip with or without cleft palate; CESC cis rs7264396 0.563 rs11698796 chr20:34248134 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.59 5.78 0.33 2.11e-8 Total cholesterol levels; CESC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg06808227 chr14:105710500 BRF1 0.49 6.38 0.36 7.9e-10 Mean platelet volume;Platelet distribution width; CESC cis rs941873 0.868 rs12780295 chr10:81115438 G/A cg09469691 chr10:81107165 PPIF 0.55 7.6 0.42 5.14e-13 Height; CESC cis rs897080 0.552 rs1067320 chr2:44633122 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC trans rs7618501 0.633 rs13060128 chr3:50025028 A/G cg21659725 chr3:3221576 CRBN 0.5 6.87 0.39 4.44e-11 Intelligence (multi-trait analysis); CESC cis rs7474896 0.537 rs1208587 chr10:38207759 A/G cg00409905 chr10:38381863 ZNF37A 0.44 5.07 0.3 7.5e-7 Obesity (extreme); CESC cis rs933688 0.941 rs2887007 chr5:90740531 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 11.96 0.59 1.22e-26 Smoking behavior; CESC cis rs854765 0.583 rs11078405 chr17:17824978 G/T cg09796270 chr17:17721594 SREBF1 0.46 6.42 0.37 6.23e-10 Total body bone mineral density; CESC cis rs2294693 0.945 rs9369253 chr6:40986538 A/G cg14769373 chr6:40998127 UNC5CL -0.48 -6.36 -0.36 8.73e-10 Gastric cancer;Non-cardia gastric cancer; CESC cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg20476274 chr7:133979776 SLC35B4 0.62 8.86 0.48 1.15e-16 Mean platelet volume; CESC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg21285383 chr16:89894308 SPIRE2 0.29 5.22 0.31 3.65e-7 Vitiligo; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg19292611 chr13:114288232 TFDP1 0.5 6.05 0.35 4.83e-9 Subjective well-being; CESC cis rs2290720 0.930 rs7314205 chr12:101722293 A/G cg22051763 chr12:101673672 UTP20 -0.49 -6.02 -0.35 5.86e-9 Brain structure (hippocampal volume); CESC cis rs2243480 1.000 rs7792391 chr7:65773429 A/G cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs4692589 0.743 rs3806825 chr4:170948619 T/C cg19918862 chr4:170955249 NA 0.44 6.77 0.38 8.1e-11 Anxiety disorder; CESC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg27170947 chr2:26402098 FAM59B -0.61 -7.31 -0.41 3.25e-12 Gut microbiome composition (summer); CESC cis rs718433 0.584 rs4982492 chr14:22212818 A/G cg02257791 chr14:22217085 NA -0.32 -5.09 -0.3 6.83e-7 Intraocular pressure; CESC cis rs3820928 0.648 rs1997484 chr2:227898962 T/A cg05526886 chr2:227700861 RHBDD1 -0.44 -5.59 -0.32 5.64e-8 Pulmonary function; CESC trans rs208520 0.690 rs2797693 chr6:66868985 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -13.06 -0.63 1.94e-30 Exhaled nitric oxide output; CESC cis rs113835537 0.529 rs57724777 chr11:66236431 G/A cg22134325 chr11:66188745 NPAS4 0.45 6.8 0.39 6.87e-11 Airway imaging phenotypes; CESC cis rs9467711 0.659 rs13220261 chr6:26499185 C/T cg21479132 chr6:26055353 NA 0.78 5.36 0.31 1.84e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7607369 0.580 rs7568196 chr2:219652373 G/A cg02176678 chr2:219576539 TTLL4 -0.49 -8.42 -0.46 2.45e-15 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs5758659 0.714 rs5758574 chr22:42481400 G/C cg04733989 chr22:42467013 NAGA -0.44 -6.21 -0.36 2e-9 Cognitive function; CESC cis rs1707322 1.000 rs785484 chr1:46574015 T/C cg06784218 chr1:46089804 CCDC17 -0.36 -5.93 -0.34 9.35e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9611565 0.592 rs4822040 chr22:41963553 C/G cg03806693 chr22:41940476 POLR3H -0.97 -11.95 -0.59 1.26e-26 Vitiligo; CESC cis rs7300001 0.538 rs7968848 chr12:110941059 T/A cg12870014 chr12:110450643 ANKRD13A 0.65 5.59 0.32 5.78e-8 Headache; CESC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg22143856 chr6:28129313 ZNF389 0.46 5.83 0.34 1.58e-8 Depression; CESC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg24250549 chr1:154909240 PMVK 0.71 10.45 0.54 1.29e-21 Prostate cancer; CESC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg21138405 chr5:131827807 IRF1 -0.38 -5.53 -0.32 7.68e-8 Breast cancer;Mosquito bite size; CESC cis rs7179456 0.557 rs446126 chr15:59113102 A/G cg05156742 chr15:59063176 FAM63B 0.72 10.04 0.52 2.61e-20 Asperger disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14909795 chr11:64851572 CDCA5;ZFPL1 0.6 6.43 0.37 5.9e-10 Gut microbiome composition (summer); CESC cis rs12200560 0.505 rs1988040 chr6:97076271 G/A cg06623918 chr6:96969491 KIAA0776 0.51 6.46 0.37 5.04e-10 Coronary heart disease; CESC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg06634786 chr22:41940651 POLR3H 0.71 6.92 0.39 3.35e-11 Vitiligo; CESC cis rs9905704 0.918 rs581903 chr17:56719197 C/T cg12560992 chr17:57184187 TRIM37 0.59 6.98 0.39 2.34e-11 Testicular germ cell tumor; CESC cis rs2710642 0.962 rs7557501 chr2:63086639 C/T cg17519650 chr2:63277830 OTX1 0.51 6.63 0.38 1.92e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs6121246 0.865 rs77130187 chr20:30269060 G/A cg13852791 chr20:30311386 BCL2L1 0.71 5.85 0.34 1.43e-8 Mean corpuscular hemoglobin; CESC cis rs13343954 0.518 rs8106293 chr19:33536376 C/T cg27124370 chr19:33622961 WDR88 0.51 7.07 0.4 1.39e-11 Colorectal cancer; CESC cis rs12893668 0.703 rs4906336 chr14:104033265 C/G cg24130564 chr14:104152367 KLC1 -0.48 -5.87 -0.34 1.31e-8 Reticulocyte count; CESC cis rs11252926 0.966 rs11252923 chr10:566195 G/A cg08603382 chr10:743973 NA -0.59 -7.52 -0.42 8.45e-13 Psychosis in Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05881776 chr2:235860554 SH3BP4 0.55 6.09 0.35 3.99e-9 Gut microbiome composition (summer); CESC cis rs959260 0.688 rs1369299 chr17:73347325 T/C cg20590849 chr17:73267439 MIF4GD -0.56 -6.27 -0.36 1.49e-9 Systemic lupus erythematosus; CESC cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg14784868 chr12:69753453 YEATS4 0.84 13.21 0.63 6.15e-31 Blood protein levels; CESC cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg05343316 chr1:45956843 TESK2 -0.52 -6.76 -0.38 8.52e-11 High light scatter reticulocyte count; CESC cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.39 0.61 3.91e-28 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.909 rs78332141 chr4:120375782 C/T cg09307838 chr4:120376055 NA 0.93 13.29 0.63 3.24e-31 Corneal astigmatism; CESC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg22903657 chr4:1355424 KIAA1530 -0.38 -5.23 -0.31 3.48e-7 Obesity-related traits; CESC cis rs115344852 0.598 rs2531815 chr6:28436060 C/T cg14547644 chr6:28411285 ZSCAN23 -0.32 -5.07 -0.3 7.31e-7 Epithelial ovarian cancer; CESC cis rs12476592 0.602 rs4671068 chr2:63798333 C/T cg17519650 chr2:63277830 OTX1 -0.48 -5.59 -0.32 5.56e-8 Childhood ear infection; CESC cis rs72627123 0.867 rs73301477 chr14:74463560 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.74 5.1 0.3 6.34e-7 Morning vs. evening chronotype; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg00231006 chr5:130599637 CDC42SE2 -0.47 -6.32 -0.36 1.13e-9 Recombination measurement; CESC cis rs72772090 0.539 rs10515249 chr5:96125259 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.26 -0.31 3.01e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2988277 0.737 rs2949668 chr1:167434721 T/C cg22356347 chr1:167427500 CD247 -0.32 -6.43 -0.37 6.01e-10 Allergic disease (asthma, hay fever or eczema); CESC cis rs17021463 0.617 rs12499187 chr4:95323917 A/G cg11021082 chr4:95130006 SMARCAD1 0.5 6.69 0.38 1.29e-10 Testicular germ cell tumor; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09578018 chr15:60883649 RORA 0.52 7.42 0.41 1.56e-12 Systemic lupus erythematosus; CESC cis rs367943 0.672 rs6594712 chr5:112715211 T/G cg12552261 chr5:112820674 MCC 0.38 5.07 0.3 7.31e-7 Type 2 diabetes; CESC cis rs7264396 0.790 rs2425125 chr20:34330954 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.63 -7.66 -0.43 3.51e-13 Total cholesterol levels; CESC cis rs11098499 0.908 rs28499576 chr4:120386677 G/A cg24375607 chr4:120327624 NA 0.44 5.44 0.32 1.19e-7 Corneal astigmatism; CESC cis rs9325144 0.505 rs901635 chr12:38646572 A/C cg13010199 chr12:38710504 ALG10B -0.46 -6.32 -0.36 1.08e-9 Morning vs. evening chronotype; CESC cis rs12681288 0.550 rs12549204 chr8:959085 G/T cg15309053 chr8:964076 NA 0.48 8.23 0.45 8.5e-15 Schizophrenia; CESC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg11644478 chr21:40555479 PSMG1 -0.8 -11.75 -0.59 6.13e-26 Cognitive function; CESC cis rs9300255 0.602 rs1626899 chr12:123708063 A/G cg05973401 chr12:123451056 ABCB9 0.5 5.68 0.33 3.48e-8 Neutrophil percentage of white cells; CESC cis rs9399137 0.507 rs28384513 chr6:135376209 T/G cg22676075 chr6:135203613 NA 0.53 7.03 0.4 1.73e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs2302190 1.000 rs7207286 chr17:56514458 A/C cg25885038 chr17:56607967 SEPT4 0.43 6.04 0.35 5.3e-9 Vitamin D levels; CESC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg08888203 chr3:10149979 C3orf24 0.44 5.39 0.31 1.57e-7 Alzheimer's disease; CESC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg05617483 chr15:76483344 C15orf27 0.38 5.13 0.3 5.49e-7 Blood metabolite levels; CESC cis rs7223966 1.000 rs13380863 chr17:61780793 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.16 0.35 2.74e-9 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.83 12.05 0.59 6.05e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7826238 0.623 rs2976893 chr8:8338219 G/T cg15556689 chr8:8085844 FLJ10661 -0.47 -5.94 -0.34 8.81e-9 Systolic blood pressure; CESC cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg17211192 chr8:82754475 SNX16 -0.58 -7.38 -0.41 2.05e-12 Diastolic blood pressure; CESC cis rs763121 0.706 rs3827356 chr22:39064806 G/T cg06022373 chr22:39101656 GTPBP1 -0.79 -12.61 -0.61 7.04e-29 Menopause (age at onset); CESC cis rs11711311 0.955 rs78029398 chr3:113421321 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.6 0.38 2.27e-10 IgG glycosylation; CESC cis rs1670533 1.000 rs13135215 chr4:1054364 A/G cg27284194 chr4:1044797 NA 0.46 5.83 0.34 1.61e-8 Recombination rate (females); CESC cis rs17384381 1.000 rs71652696 chr1:85831792 A/C cg16011679 chr1:85725395 C1orf52 0.83 8.29 0.45 5.92e-15 Lobe attachment (rater-scored or self-reported); CESC cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.63 -8.83 -0.48 1.42e-16 Personality dimensions; CESC cis rs7044106 0.648 rs2031369 chr9:123360294 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.22 0.31 3.62e-7 Hip circumference adjusted for BMI; CESC cis rs60154123 0.772 rs664072 chr1:210422160 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.49 5.1 0.3 6.34e-7 Coronary artery disease; CESC cis rs4523957 0.855 rs216172 chr17:2126504 G/C cg16513277 chr17:2031491 SMG6 -0.59 -8.03 -0.44 3.23e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs5769765 0.728 rs6520064 chr22:50294469 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.21 -0.3 3.79e-7 Schizophrenia; CESC cis rs6963495 0.818 rs711430 chr7:105167969 A/G cg19920283 chr7:105172520 RINT1 0.72 8.05 0.44 2.75e-14 Bipolar disorder (body mass index interaction); CESC trans rs8057939 0.593 rs11860577 chr16:49435600 C/T cg15532236 chr6:170188124 NA 0.49 6.1 0.35 3.68e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs11958404 0.932 rs72816556 chr5:157424412 C/G cg05962755 chr5:157440814 NA 0.58 6.4 0.37 7.16e-10 IgG glycosylation; CESC cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg18351406 chr4:77819688 ANKRD56 0.54 6.74 0.38 1.01e-10 Emphysema distribution in smoking; CESC cis rs478304 0.651 rs4930312 chr11:65499719 G/A cg10518572 chr11:65560635 OVOL1 -0.33 -6.61 -0.38 2.09e-10 Acne (severe); CESC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs7216064 1.000 rs8082512 chr17:65837059 T/C cg12091567 chr17:66097778 LOC651250 -0.86 -8.83 -0.48 1.49e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 11.36 0.57 1.3e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg15017067 chr4:17643749 FAM184B 0.39 5.47 0.32 1.02e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2742417 0.609 rs2673066 chr3:45771200 C/T cg04837898 chr3:45731254 SACM1L -0.47 -6.17 -0.35 2.54e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs10504229 0.871 rs10504226 chr8:58159283 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -8.2 -0.45 1.04e-14 Developmental language disorder (linguistic errors); CESC cis rs9399135 0.967 rs4896125 chr6:135342569 C/T cg24558204 chr6:135376177 HBS1L 0.52 7.29 0.41 3.48e-12 Red blood cell count; CESC cis rs7208859 0.573 rs216442 chr17:28931197 T/G cg19761014 chr17:28927070 LRRC37B2 0.85 6.59 0.38 2.33e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9457247 0.663 rs9295384 chr6:167448113 T/A cg07741184 chr6:167504864 NA 0.34 6.02 0.35 5.87e-9 Crohn's disease; CESC cis rs4132509 1.000 rs12116882 chr1:243959106 G/A cg21452805 chr1:244014465 NA 0.49 5.95 0.34 8.28e-9 RR interval (heart rate); CESC cis rs897984 0.683 rs8050330 chr16:30824970 C/T cg02466173 chr16:30829666 NA -0.64 -12.49 -0.61 1.77e-28 Dementia with Lewy bodies; CESC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg06212747 chr3:49208901 KLHDC8B 0.77 11.49 0.58 4.66e-25 Menarche (age at onset); CESC cis rs7927592 0.913 rs10896347 chr11:68353127 G/A cg20283391 chr11:68216788 NA -0.61 -7.29 -0.41 3.48e-12 Total body bone mineral density; CESC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg11301795 chr4:187892539 NA -0.8 -14.13 -0.66 3.5e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs10883723 0.669 rs2001595 chr10:104395085 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.51 5.54 0.32 7.29e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs1008375 0.966 rs2191504 chr4:17675592 C/G cg02297831 chr4:17616191 MED28 0.45 5.64 0.33 4.42e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs13272623 0.502 rs268562 chr8:71494780 G/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.49 -6.11 -0.35 3.57e-9 IgG glycosylation; CESC cis rs858239 0.601 rs10278776 chr7:23169759 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.73 0.43 2.27e-13 Cerebrospinal fluid biomarker levels; CESC cis rs7927771 0.832 rs896816 chr11:47394338 T/C cg18512352 chr11:47633146 NA 0.49 6.89 0.39 4.11e-11 Subjective well-being; CESC cis rs2279817 0.863 rs12023877 chr1:18025633 A/C cg21791023 chr1:18019539 ARHGEF10L 0.54 7.88 0.44 8.25e-14 Neuroticism; CESC cis rs4563143 0.514 rs73029081 chr19:29295583 C/G cg12756686 chr19:29218302 NA 0.54 6.27 0.36 1.46e-9 Methadone dose in opioid dependence; CESC cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg13880726 chr7:1868755 MAD1L1 -0.48 -5.08 -0.3 7.17e-7 Bipolar disorder; CESC cis rs11098499 0.566 rs17051356 chr4:120585308 C/T cg24375607 chr4:120327624 NA 0.43 5.25 0.31 3.11e-7 Corneal astigmatism; CESC cis rs6587515 0.901 rs10888396 chr1:150777514 T/C cg13175981 chr1:150552382 MCL1 0.61 5.06 0.3 7.99e-7 Pericardial adipose tissue adjusted for height and weight; CESC cis rs2274273 0.870 rs1952087 chr14:55683211 A/C cg04306507 chr14:55594613 LGALS3 0.29 5.83 0.34 1.64e-8 Protein biomarker; CESC cis rs6748734 0.625 rs4295000 chr2:241821237 C/T cg04034577 chr2:241836375 C2orf54 -0.29 -5.25 -0.31 3.05e-7 Urinary metabolites; CESC cis rs4423214 0.879 rs10898144 chr11:71151540 A/T cg05163923 chr11:71159392 DHCR7 -0.65 -7.95 -0.44 5.37e-14 Vitamin D levels; CESC cis rs5769765 0.874 rs4624 chr22:50281917 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs6543140 0.964 rs2080288 chr2:103022166 G/A cg04239558 chr2:103089729 SLC9A4 0.49 6.15 0.35 2.83e-9 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19519331 chr10:91403645 PANK1 -0.57 -6.84 -0.39 5.37e-11 Gut microbiome composition (summer); CESC cis rs4888262 0.526 rs4888253 chr16:74583146 C/T cg01733217 chr16:74700730 RFWD3 0.81 11.45 0.58 6.4e-25 Testicular germ cell tumor; CESC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg16049864 chr8:95962084 TP53INP1 -0.67 -11.87 -0.59 2.36e-26 Type 2 diabetes; CESC cis rs7212590 0.881 rs7214032 chr17:57885828 T/C cg20303301 chr17:57937339 TUBD1 -0.55 -5.28 -0.31 2.67e-7 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs7429990 0.932 rs6803741 chr3:48123540 C/T cg11946769 chr3:48343235 NME6 -0.5 -6.26 -0.36 1.53e-9 Educational attainment (years of education); CESC cis rs7615952 0.673 rs16834637 chr3:125605471 C/T cg05084668 chr3:125655381 ALG1L -0.58 -6.39 -0.37 7.5e-10 Blood pressure (smoking interaction); CESC cis rs6952809 0.532 rs10227362 chr7:2456799 A/G cg23289794 chr7:2394357 EIF3B -0.74 -7.04 -0.4 1.62e-11 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13094338 chr20:62258937 GMEB2 -0.59 -6.63 -0.38 1.86e-10 Gut microbiome composition (summer); CESC cis rs60843830 1.000 rs17713729 chr2:249092 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.8 10.42 0.54 1.55e-21 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs9322193 0.884 rs9383864 chr6:150173105 T/C cg07701084 chr6:150067640 NUP43 0.4 5.23 0.31 3.41e-7 Lung cancer; CESC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.66 9.08 0.49 2.51e-17 Menopause (age at onset); CESC cis rs7659604 0.521 rs6822155 chr4:122673274 C/A cg19671926 chr4:122722719 EXOSC9 0.59 7.44 0.42 1.44e-12 Type 2 diabetes; CESC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.94 0.52 5.59e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg04369109 chr6:150039330 LATS1 -0.43 -5.91 -0.34 1.05e-8 Lung cancer; CESC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg09877947 chr5:131593287 PDLIM4 0.48 6.28 0.36 1.39e-9 Breast cancer; CESC cis rs6964587 0.869 rs406 chr7:91546526 C/A cg01689657 chr7:91764605 CYP51A1 -0.28 -5.06 -0.3 7.76e-7 Breast cancer; CESC trans rs208520 0.690 rs207118 chr6:66788948 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.83 -0.62 1.2e-29 Exhaled nitric oxide output; CESC cis rs9361491 0.621 rs12196457 chr6:79627743 A/T cg05283184 chr6:79620031 NA -0.37 -5.23 -0.31 3.45e-7 Intelligence (multi-trait analysis); CESC cis rs9325144 0.560 rs11182930 chr12:38633693 A/T cg26384229 chr12:38710491 ALG10B -0.61 -8.58 -0.47 8.35e-16 Morning vs. evening chronotype; CESC cis rs863345 0.967 rs10908680 chr1:158521961 T/C cg12129480 chr1:158549410 OR10X1 -0.31 -6.18 -0.36 2.35e-9 Pneumococcal bacteremia; CESC cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.23 0.31 3.41e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs546131 0.928 rs516228 chr11:34838823 C/T cg06937548 chr11:34938143 PDHX;APIP 0.51 6.42 0.37 6.29e-10 Lung disease severity in cystic fibrosis; CESC cis rs524281 0.861 rs9736673 chr11:65924024 T/A cg14036092 chr11:66035641 RAB1B -0.49 -5.17 -0.3 4.67e-7 Electroencephalogram traits; CESC cis rs4481887 0.830 rs4474289 chr1:248474972 T/A cg00666640 chr1:248458726 OR2T12 0.34 5.62 0.33 4.8e-8 Common traits (Other); CESC cis rs9905704 0.633 rs2632518 chr17:56512236 T/C cg12560992 chr17:57184187 TRIM37 0.6 5.62 0.33 4.8e-8 Testicular germ cell tumor; CESC cis rs4595586 0.679 rs7131749 chr12:39405462 A/G cg26384229 chr12:38710491 ALG10B -0.42 -6.19 -0.36 2.23e-9 Morning vs. evening chronotype; CESC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg17294928 chr15:75287854 SCAMP5 0.49 6.2 0.36 2.17e-9 Breast cancer; CESC cis rs7503807 0.935 rs7215534 chr17:78612119 C/T cg09596252 chr17:78655493 RPTOR 0.47 6.87 0.39 4.51e-11 Obesity; CESC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg13114125 chr14:105738426 BRF1 -0.85 -10.46 -0.54 1.18e-21 Mean platelet volume;Platelet distribution width; CESC cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.8 0.48 1.79e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9837602 1.000 rs35844878 chr3:99796626 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 6.84 0.39 5.32e-11 Breast cancer; CESC cis rs854765 0.964 rs854764 chr17:18011750 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.46 -5.81 -0.34 1.82e-8 Total body bone mineral density; CESC cis rs17384381 0.953 rs2076699 chr1:85817295 G/A cg16011679 chr1:85725395 C1orf52 0.8 8.13 0.45 1.69e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.72 -0.33 2.81e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12781834 chr17:40169085 DNAJC7;NKIRAS2 0.57 6.25 0.36 1.59e-9 Gut microbiome composition (summer); CESC cis rs4523957 0.893 rs12950555 chr17:2156910 C/G cg16513277 chr17:2031491 SMG6 0.6 8.27 0.45 6.71e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1348850 0.567 rs3770012 chr2:178538023 A/G cg22681709 chr2:178499509 PDE11A 0.49 7.4 0.41 1.78e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs2066819 1.000 rs2020854 chr12:56743367 T/C cg26734620 chr12:56694298 CS 0.88 8.73 0.47 2.85e-16 Psoriasis vulgaris; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09386619 chr6:125420923 NA -0.57 -7.11 -0.4 1.05e-11 Ulcerative colitis; CESC cis rs8005677 1.000 rs8006396 chr14:23380850 A/G cg25600027 chr14:23388339 RBM23 -0.43 -5.33 -0.31 2.08e-7 Cognitive ability (multi-trait analysis); CESC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.95 14.1 0.65 4.6e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs735396 1.000 rs2259816 chr12:121435587 A/C cg02403541 chr12:121454288 C12orf43 -0.61 -8.91 -0.48 8.13e-17 N-glycan levels; CESC cis rs9948 0.521 rs62156207 chr2:97359236 C/A cg01990225 chr2:97406019 LMAN2L -0.79 -6.42 -0.37 6.44e-10 Erectile dysfunction and prostate cancer treatment; CESC cis rs6565180 0.632 rs8050812 chr16:30385837 C/T cg17640201 chr16:30407289 ZNF48 -0.85 -11.53 -0.58 3.45e-25 Tonsillectomy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03191116 chr12:72058171 ZFC3H1;THAP2 0.47 6.25 0.36 1.61e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs67311347 1.000 rs4973997 chr3:40460145 G/A cg24209194 chr3:40518798 ZNF619 0.46 6.0 0.35 6.33e-9 Renal cell carcinoma; CESC cis rs2882667 0.858 rs35812969 chr5:138377550 G/C cg04439458 chr5:138467593 SIL1 -0.4 -6.15 -0.35 2.89e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.64 0.47 5.31e-16 Hip circumference adjusted for BMI; CESC cis rs933688 1.000 rs12651840 chr5:90729592 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 1.01 13.73 0.64 8.84e-33 Smoking behavior; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05867387 chr4:170679069 C4orf27 0.52 6.01 0.35 6.05e-9 Gut microbiome composition (summer); CESC cis rs4253772 0.591 rs6008365 chr22:46652929 G/A cg09491104 chr22:46646882 C22orf40 -0.6 -9.25 -0.49 7.56e-18 LDL cholesterol;Cholesterol, total; CESC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg18876405 chr7:65276391 NA 0.5 6.84 0.39 5.47e-11 Aortic root size; CESC cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.3 0.31 2.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs637571 0.544 rs12361552 chr11:65701204 G/A cg02427764 chr11:65769310 BANF1;EIF1AD -0.63 -8.24 -0.45 8.11e-15 Eosinophil percentage of white cells; CESC cis rs939574 1.000 rs56927225 chr2:220100922 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.82 7.21 0.41 5.76e-12 Platelet distribution width; CESC cis rs12477438 0.520 rs13023744 chr2:99738224 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.09 0.7 4.08e-41 Chronic sinus infection; CESC cis rs7674212 0.541 rs2251322 chr4:104079424 C/T cg16532752 chr4:104119610 CENPE -0.45 -6.18 -0.36 2.37e-9 Type 2 diabetes; CESC cis rs7267979 1.000 rs7267979 chr20:25298087 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.86 16.91 0.72 5.14e-44 Liver enzyme levels (alkaline phosphatase); CESC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg03576123 chr11:487126 PTDSS2 -1.1 -10.38 -0.54 2.07e-21 Body mass index; CESC cis rs1707322 0.717 rs28396194 chr1:46213227 C/T cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11626933 1.000 rs11621007 chr14:90743967 G/A cg14092571 chr14:90743983 NA -1.01 -16.28 -0.71 8.56e-42 Gut microbiota (bacterial taxa); CESC cis rs1538970 1.000 rs2050884 chr1:45830824 A/G cg05343316 chr1:45956843 TESK2 0.76 10.54 0.54 6.54e-22 Platelet count; CESC cis rs7267979 1.000 rs2257496 chr20:25279315 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.72 0.75 2.09e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs7659604 0.846 rs35986491 chr4:122664528 A/T cg19671926 chr4:122722719 EXOSC9 -0.45 -5.26 -0.31 2.96e-7 Type 2 diabetes; CESC cis rs7923609 0.967 rs10761729 chr10:64995604 G/C cg01631684 chr10:65280961 REEP3 -0.45 -5.56 -0.32 6.57e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25621096 chr1:151032116 CDC42SE1;MLLT11 0.6 6.81 0.39 6.47e-11 Gut microbiome composition (summer); CESC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.99 -0.56 2.15e-23 Alzheimer's disease; CESC cis rs7786808 0.505 rs67537656 chr7:158192646 C/T cg09998033 chr7:158218633 PTPRN2 0.35 5.31 0.31 2.32e-7 Obesity-related traits; CESC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg16545954 chr1:2118288 C1orf86 0.35 6.55 0.37 2.95e-10 Height; CESC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -7.04 -0.4 1.67e-11 Bipolar disorder and schizophrenia; CESC cis rs9549367 0.713 rs3024746 chr13:113821777 G/A cg18105134 chr13:113819100 PROZ -0.66 -8.35 -0.46 3.82e-15 Platelet distribution width; CESC cis rs1707322 0.717 rs3014249 chr1:46079493 A/G cg06784218 chr1:46089804 CCDC17 -0.41 -7.07 -0.4 1.34e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2228479 0.717 rs1800358 chr16:89809319 T/C cg04287289 chr16:89883240 FANCA 0.71 6.53 0.37 3.42e-10 Skin colour saturation; CESC cis rs921968 0.565 rs7599365 chr2:219620566 G/A cg02176678 chr2:219576539 TTLL4 -0.44 -7.74 -0.43 2.08e-13 Mean corpuscular hemoglobin concentration; CESC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.2 0.4 6.15e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2243480 1.000 rs6460260 chr7:65215455 T/C cg12463550 chr7:65579703 CRCP -0.7 -5.35 -0.31 1.89e-7 Diabetic kidney disease; CESC cis rs2243480 1.000 rs1638734 chr7:66097539 A/C cg18252515 chr7:66147081 NA -1.4 -14.2 -0.66 2.03e-34 Diabetic kidney disease; CESC cis rs7927592 0.913 rs4988291 chr11:68381607 G/A cg20283391 chr11:68216788 NA -0.61 -7.37 -0.41 2.24e-12 Total body bone mineral density; CESC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg11247378 chr22:39784982 NA -0.64 -9.23 -0.49 9.24e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7580658 0.895 rs4662580 chr2:128102806 C/A cg10021288 chr2:128175891 PROC -0.41 -6.46 -0.37 5.11e-10 Protein C levels; CESC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.91 -0.56 3.89e-23 Developmental language disorder (linguistic errors); CESC cis rs7264396 0.511 rs2425102 chr20:34312303 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.86 0.39 4.78e-11 Total cholesterol levels; CESC cis rs10791097 0.748 rs4937580 chr11:130734270 T/C cg12179176 chr11:130786555 SNX19 0.63 9.81 0.52 1.39e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2180341 0.640 rs11154395 chr6:127629138 T/C cg24812749 chr6:127587940 RNF146 0.62 8.22 0.45 8.91e-15 Breast cancer; CESC cis rs7582720 1.000 rs72936838 chr2:203772984 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs4588572 0.606 rs2362828 chr5:77718835 C/T cg11547950 chr5:77652471 NA -0.4 -5.58 -0.32 5.84e-8 Triglycerides; CESC cis rs6933660 0.683 rs8180642 chr6:151756612 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.8 12.41 0.61 3.4e-28 Menarche (age at onset); CESC cis rs4237845 0.837 rs7963992 chr12:58295949 G/C cg00677455 chr12:58241039 CTDSP2 0.43 5.39 0.31 1.52e-7 Intelligence (multi-trait analysis); CESC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg11764359 chr7:65958608 NA 0.7 8.8 0.48 1.84e-16 Aortic root size; CESC cis rs9660992 0.573 rs12125276 chr1:205199440 C/T cg21643547 chr1:205240462 TMCC2 -0.39 -5.37 -0.31 1.76e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs67311347 0.911 rs9863737 chr3:40439836 C/T cg24209194 chr3:40518798 ZNF619 0.51 6.42 0.37 6.35e-10 Renal cell carcinoma; CESC trans rs2530545 0.851 rs59297232 chr7:34692183 C/T cg14080982 chr15:71736038 THSD4 -0.48 -6.27 -0.36 1.43e-9 IgG glycosylation; CESC cis rs919433 0.963 rs10153881 chr2:198171098 T/C cg10820045 chr2:198174542 NA -0.36 -5.08 -0.3 7.09e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg04287289 chr16:89883240 FANCA 0.89 15.36 0.69 1.58e-38 Vitiligo; CESC cis rs1348850 0.519 rs1527407 chr2:178525630 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.05 0.4 1.57e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1775715 0.870 rs11008696 chr10:32218614 G/A cg04359828 chr10:32216031 ARHGAP12 0.38 5.23 0.31 3.5e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs4680 0.737 rs4818 chr22:19951207 C/G cg23601416 chr22:19950040 COMT -0.28 -5.25 -0.31 3.06e-7 Blood metabolite levels; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg19796955 chr12:64895570 TBK1 0.37 6.36 0.36 8.76e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs17253792 0.822 rs75049893 chr14:56089158 A/G cg01858014 chr14:56050164 KTN1 -0.91 -7.19 -0.4 6.49e-12 Putamen volume; CESC cis rs9583531 0.689 rs9521913 chr13:111382058 C/T cg15841412 chr13:111365552 ING1 -0.42 -5.15 -0.3 5.08e-7 Coronary artery disease; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg10002088 chr19:9271911 ZNF317 -0.49 -6.39 -0.37 7.55e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg13393036 chr8:95962371 TP53INP1 -0.48 -10.36 -0.54 2.51e-21 Type 2 diabetes; CESC cis rs9291683 0.509 rs998676 chr4:9948564 T/C cg02734326 chr4:10020555 SLC2A9 -0.45 -6.73 -0.38 1.06e-10 Bone mineral density; CESC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg19099843 chr7:12443191 VWDE -0.51 -6.26 -0.36 1.52e-9 Coronary artery disease; CESC cis rs2235544 0.639 rs72664117 chr1:54476931 A/G cg25741118 chr1:54482237 LDLRAD1 -0.26 -6.32 -0.36 1.09e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs7647973 0.626 rs4855846 chr3:49683526 G/A cg07636037 chr3:49044803 WDR6 0.53 6.41 0.37 6.49e-10 Menarche (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24863706 chr4:120549163 PDE5A -0.48 -6.26 -0.36 1.56e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs34375054 0.526 rs883315 chr12:125676889 T/C cg25124228 chr12:125621409 AACS -0.5 -5.84 -0.34 1.49e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs12347191 0.500 rs973473 chr9:100620730 T/G cg13688889 chr9:100608707 NA -0.91 -13.42 -0.64 1.07e-31 Orofacial clefts; CESC cis rs4664308 0.840 rs1870102 chr2:161070582 A/G cg03641300 chr2:160917029 PLA2R1 -0.62 -8.88 -0.48 1.04e-16 Idiopathic membranous nephropathy; CESC cis rs9487051 0.676 rs9398193 chr6:109593134 G/T cg12927641 chr6:109611667 NA -0.37 -5.56 -0.32 6.55e-8 Reticulocyte fraction of red cells; CESC cis rs68170813 0.559 rs3815148 chr7:106938420 G/T cg02696742 chr7:106810147 HBP1 0.55 5.57 0.32 6.21e-8 Coronary artery disease; CESC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg00310523 chr12:86230176 RASSF9 0.35 5.71 0.33 3.01e-8 Major depressive disorder; CESC cis rs10504073 0.647 rs4873314 chr8:50011656 A/C cg00325661 chr8:49890786 NA 0.57 8.56 0.47 9.52e-16 Blood metabolite ratios; CESC cis rs780094 0.585 rs7586601 chr2:27584666 A/G cg21248554 chr2:27665150 KRTCAP3 -0.26 -5.34 -0.31 1.97e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs4853012 0.838 rs2177707 chr2:74356850 A/G cg05890377 chr2:74357713 NA 0.74 9.2 0.49 1.1e-17 Gestational age at birth (maternal effect); CESC cis rs6141600 0.760 rs2590991 chr20:34716238 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -5.12 -0.3 5.83e-7 Height;Hip circumference; CESC cis rs965469 0.779 rs6133031 chr20:3300857 A/C cg25506879 chr20:3388711 C20orf194 -0.49 -5.41 -0.32 1.44e-7 IFN-related cytopenia; CESC cis rs7264396 0.676 rs6058380 chr20:34552900 T/G cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.1 0.35 3.72e-9 Total cholesterol levels; CESC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg04703951 chr17:43578652 NA 0.51 6.16 0.35 2.63e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs593982 0.920 rs487264 chr11:65481465 A/C cg08755490 chr11:65554678 OVOL1 1.15 10.39 0.54 2.01e-21 Atopic dermatitis; CESC cis rs1395 0.778 rs12465084 chr2:27414203 G/C cg22903471 chr2:27725779 GCKR -0.42 -5.21 -0.3 3.81e-7 Blood metabolite levels; CESC cis rs7312933 0.558 rs55702525 chr12:42814309 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.5 -6.72 -0.38 1.08e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg15787769 chr11:842744 TSPAN4;POLR2L -0.7 -9.31 -0.5 5.22e-18 Mean platelet volume; CESC cis rs61931739 0.517 rs7313663 chr12:34417058 T/C cg06521331 chr12:34319734 NA -0.37 -5.12 -0.3 5.75e-7 Morning vs. evening chronotype; CESC cis rs992157 0.735 rs12990082 chr2:219102332 C/T cg00012203 chr2:219082015 ARPC2 0.85 12.27 0.6 1.07e-27 Colorectal cancer; CESC cis rs12464559 0.649 rs10754989 chr2:152642235 T/C cg01189475 chr2:152685088 ARL5A 0.72 6.22 0.36 1.95e-9 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs8060686 0.920 rs73591976 chr16:67811590 C/A cg26727032 chr16:67993705 SLC12A4 -0.59 -6.16 -0.35 2.69e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04407579 chr13:99228509 STK24 0.55 6.36 0.36 8.82e-10 Gut microbiome composition (summer); CESC cis rs2749592 0.611 rs2505199 chr10:38392457 G/A cg00409905 chr10:38381863 ZNF37A -0.54 -6.97 -0.39 2.46e-11 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs362272 0.545 rs2749783 chr4:3326098 A/C cg08886695 chr4:3369023 RGS12 -0.42 -5.84 -0.34 1.52e-8 Serum sulfate level; CESC trans rs57221529 0.766 rs28563961 chr5:554498 C/G cg25482853 chr8:67687455 SGK3 1.12 10.9 0.56 4.19e-23 Lung disease severity in cystic fibrosis; CESC cis rs7274811 0.711 rs291669 chr20:31945364 C/T cg21523528 chr20:32077966 CBFA2T2 -0.44 -5.64 -0.33 4.32e-8 Height; CESC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.73 -0.33 2.72e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs9831754 1.000 rs1028024 chr3:78371577 A/C cg06138941 chr3:78371609 NA -0.76 -8.76 -0.47 2.34e-16 Calcium levels; CESC cis rs1506636 1.000 rs659416 chr7:123401764 A/G cg03229431 chr7:123269106 ASB15 -0.5 -6.53 -0.37 3.34e-10 Plateletcrit;Platelet count; CESC cis rs1957429 0.634 rs59000318 chr14:65419473 C/A cg23373153 chr14:65346875 NA -0.8 -8.13 -0.45 1.7e-14 Pediatric areal bone mineral density (radius); CESC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.65 9.25 0.49 7.64e-18 Menopause (age at onset); CESC cis rs4450798 0.793 rs9831150 chr3:13740916 C/T cg23332027 chr3:13681764 NA 0.4 5.36 0.31 1.81e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg18016565 chr1:150552671 MCL1 0.33 5.16 0.3 4.96e-7 Tonsillectomy; CESC cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg03013636 chr16:1946785 NA 0.5 6.43 0.37 5.92e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs1124376 0.810 rs6807771 chr3:20160634 C/A cg05072819 chr3:20081367 KAT2B 0.5 5.59 0.32 5.7e-8 Bipolar disorder and schizophrenia; CESC cis rs3858526 0.834 rs10839166 chr11:6002464 T/C cg13902645 chr11:5959945 NA -0.47 -5.45 -0.32 1.13e-7 DNA methylation (variation); CESC cis rs73001065 0.636 rs10415849 chr19:19505087 C/T cg03709012 chr19:19516395 GATAD2A 0.89 7.25 0.41 4.66e-12 LDL cholesterol; CESC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.86 -12.57 -0.61 9.53e-29 Prudent dietary pattern; CESC cis rs9914578 1.000 rs4061660 chr17:2004377 C/T cg16513277 chr17:2031491 SMG6 -0.6 -7.02 -0.4 1.89e-11 Body mass index; CESC cis rs2806561 0.765 rs681395 chr1:23500314 G/A cg12483005 chr1:23474871 LUZP1 0.39 6.21 0.36 2.05e-9 Height; CESC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg18032046 chr6:28092343 ZSCAN16 -0.53 -6.03 -0.35 5.5e-9 Depression; CESC trans rs9858542 0.953 rs7622302 chr3:49547561 T/C cg21659725 chr3:3221576 CRBN -0.55 -6.49 -0.37 4.26e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7937682 0.855 rs11213985 chr11:111581521 C/A cg09085632 chr11:111637200 PPP2R1B -1.02 -17.06 -0.72 1.51e-44 Primary sclerosing cholangitis; CESC cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg21573476 chr21:45109991 RRP1B -0.51 -7.01 -0.4 1.93e-11 Mean corpuscular volume; CESC cis rs9916302 0.904 rs35335692 chr17:37710006 A/G cg20243544 chr17:37824526 PNMT 0.52 6.56 0.37 2.77e-10 Glomerular filtration rate (creatinine); CESC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg12963246 chr6:28129442 ZNF389 0.42 5.68 0.33 3.48e-8 Parkinson's disease; CESC cis rs4642101 0.824 rs9852222 chr3:12848491 G/T cg05775895 chr3:12838266 CAND2 0.39 5.78 0.33 2.1e-8 QRS complex (12-leadsum); CESC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg18876405 chr7:65276391 NA 0.53 7.32 0.41 3.01e-12 Aortic root size; CESC cis rs4474465 0.850 rs4565922 chr11:78260699 A/G cg27205649 chr11:78285834 NARS2 0.41 5.22 0.31 3.61e-7 Alzheimer's disease (survival time); CESC cis rs2486288 0.587 rs12899942 chr15:45547280 T/C cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.54 -0.37 3.21e-10 Glomerular filtration rate; CESC cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg18357526 chr6:26021779 HIST1H4A 0.46 5.59 0.32 5.76e-8 Intelligence (multi-trait analysis); CESC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg04414720 chr1:150670196 GOLPH3L -0.37 -5.17 -0.3 4.64e-7 Lymphocyte counts; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg05793409 chr1:35658810 SFPQ -0.46 -6.66 -0.38 1.61e-10 Vertical cup-disc ratio; CESC cis rs9611565 0.918 rs2281333 chr22:41749630 T/C cg03806693 chr22:41940476 POLR3H -0.77 -9.39 -0.5 2.97e-18 Vitiligo; CESC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg13902645 chr11:5959945 NA -0.59 -7.36 -0.41 2.36e-12 DNA methylation (variation); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24725560 chr11:32605793 EIF3M -0.45 -6.35 -0.36 9.17e-10 Gambling; CESC cis rs3020736 0.500 rs6002618 chr22:42507859 G/C cg04733989 chr22:42467013 NAGA -0.78 -11.9 -0.59 1.87e-26 Autism spectrum disorder or schizophrenia; CESC cis rs1355223 0.867 rs7944030 chr11:34691738 A/T cg11058730 chr11:34937778 PDHX;APIP -0.53 -6.88 -0.39 4.42e-11 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg11644478 chr21:40555479 PSMG1 -0.79 -11.61 -0.58 1.77e-25 Cognitive function; CESC cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg20503657 chr10:835505 NA 0.71 6.4 0.37 6.85e-10 Eosinophil percentage of granulocytes; CESC cis rs478304 0.934 rs506853 chr11:65521247 C/T cg08755490 chr11:65554678 OVOL1 0.46 6.15 0.35 2.85e-9 Acne (severe); CESC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg04756594 chr16:24857601 SLC5A11 0.45 5.52 0.32 8.21e-8 Intelligence (multi-trait analysis); CESC cis rs858239 0.600 rs4409314 chr7:23127952 T/C cg23682824 chr7:23144976 KLHL7 0.51 6.92 0.39 3.47e-11 Cerebrospinal fluid biomarker levels; CESC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg20271620 chr17:80763330 TBCD 0.46 5.39 0.31 1.59e-7 Breast cancer; CESC cis rs9916302 0.706 rs667239 chr17:37442241 A/G cg00129232 chr17:37814104 STARD3 0.49 5.42 0.32 1.31e-7 Glomerular filtration rate (creatinine); CESC cis rs76917914 0.820 rs7020081 chr9:100823360 C/A cg03040243 chr9:100819229 NANS 0.46 5.14 0.3 5.36e-7 Immature fraction of reticulocytes; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg06134974 chr12:51477539 CSRNP2 0.49 6.64 0.38 1.78e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4844614 1.000 rs12038371 chr1:207821046 A/G cg21110645 chr1:207815933 NA 0.37 5.68 0.33 3.61e-8 LDL cholesterol; CESC cis rs66573146 1.000 rs6838042 chr4:6973049 G/T cg00086871 chr4:6988644 TBC1D14 0.89 5.77 0.33 2.22e-8 Granulocyte percentage of myeloid white cells; CESC cis rs12681288 0.676 rs34435811 chr8:990630 T/A cg04851639 chr8:1020857 NA -0.31 -6.66 -0.38 1.59e-10 Schizophrenia; CESC cis rs7100689 0.516 rs10887711 chr10:82034842 A/G cg00277334 chr10:82204260 NA -0.46 -5.76 -0.33 2.28e-8 Post bronchodilator FEV1; CESC cis rs8077577 0.689 rs2273029 chr17:18236339 G/A cg16794390 chr17:18148240 FLII 0.41 6.45 0.37 5.33e-10 Obesity-related traits; CESC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg25767906 chr1:53392781 SCP2 0.43 5.94 0.34 9.04e-9 Monocyte count; CESC cis rs227584 0.663 rs2040810 chr17:42243771 C/T cg19774624 chr17:42201019 HDAC5 0.69 10.27 0.53 4.8e-21 Bone mineral density (hip);Bone mineral density; CESC cis rs10256972 0.626 rs62433138 chr7:1050877 T/C cg00431813 chr7:1051703 C7orf50 -0.56 -9.46 -0.5 1.8e-18 Longevity;Endometriosis; CESC cis rs6460942 1.000 rs62448563 chr7:12400040 G/A cg02935154 chr7:12443704 VWDE -0.57 -6.15 -0.35 2.77e-9 Coronary artery disease; CESC cis rs11098499 0.863 rs12508173 chr4:120318526 T/C cg24375607 chr4:120327624 NA 0.47 5.73 0.33 2.74e-8 Corneal astigmatism; CESC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg02725872 chr8:58115012 NA -0.44 -6.08 -0.35 4.08e-9 Developmental language disorder (linguistic errors); CESC cis rs9633740 1.000 rs1870137 chr10:82269848 C/G cg00277334 chr10:82204260 NA -0.58 -5.78 -0.33 2.15e-8 Post bronchodilator FEV1; CESC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg02569458 chr12:86230093 RASSF9 -0.44 -6.62 -0.38 2.02e-10 Major depressive disorder; CESC cis rs1008375 0.932 rs6845288 chr4:17665498 A/T cg16339924 chr4:17578868 LAP3 -0.66 -7.59 -0.42 5.58e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1003719 0.788 rs9974286 chr21:38456832 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.58 -8.09 -0.45 2.14e-14 Eye color traits; CESC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01517940 chr14:69865233 SLC39A9;ERH -0.45 -6.3 -0.36 1.2e-9 Gut microbiota (bacterial taxa); CESC cis rs2243480 1.000 rs160633 chr7:65528228 T/C cg12463550 chr7:65579703 CRCP 0.65 5.26 0.31 3.04e-7 Diabetic kidney disease; CESC cis rs3126085 0.935 rs12726613 chr1:152185500 C/G cg26876637 chr1:152193138 HRNR -0.44 -5.03 -0.3 9.04e-7 Atopic dermatitis; CESC cis rs6582630 0.537 rs3942440 chr12:38459672 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.11 0.35 3.63e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7714584 1.000 rs6875011 chr5:150182710 G/A cg22134413 chr5:150180641 NA 0.62 5.79 0.34 1.96e-8 Crohn's disease; CESC cis rs854765 0.647 rs8066764 chr17:17974668 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 8.64 0.47 5.3e-16 Total body bone mineral density; CESC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.39 5.86 0.34 1.41e-8 Cystic fibrosis severity; CESC cis rs6502050 0.769 rs8079122 chr17:80120427 G/T cg23985595 chr17:80112537 CCDC57 -0.4 -6.17 -0.35 2.56e-9 Life satisfaction; CESC cis rs67311347 0.822 rs9826847 chr3:40345312 A/T cg09455208 chr3:40491958 NA 0.43 7.02 0.4 1.81e-11 Renal cell carcinoma; CESC cis rs11098499 0.954 rs11098525 chr4:120390152 G/A cg24375607 chr4:120327624 NA 0.45 5.61 0.33 5.1e-8 Corneal astigmatism; CESC cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg15605315 chr1:45957053 TESK2 0.48 6.41 0.37 6.69e-10 High light scatter reticulocyte count; CESC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg15664640 chr17:80829946 TBCD 0.65 9.57 0.51 7.85e-19 Breast cancer; CESC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg02725872 chr8:58115012 NA -0.44 -6.87 -0.39 4.48e-11 Developmental language disorder (linguistic errors); CESC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg06456125 chr7:65229604 NA 0.43 5.61 0.33 5.03e-8 Calcium levels; CESC cis rs1499972 0.878 rs817513 chr3:117733823 A/T cg07612923 chr3:117604196 NA -0.8 -5.97 -0.34 7.5e-9 Schizophrenia; CESC cis rs2019216 0.564 rs907707 chr17:21910083 G/C cg22648282 chr17:21454238 C17orf51 -0.44 -5.96 -0.34 7.89e-9 Pelvic organ prolapse; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19245296 chr20:10015646 ANKRD5 0.62 6.93 0.39 3.17e-11 Gut microbiome composition (summer); CESC trans rs561341 1.000 rs530715 chr17:30320544 T/G cg27661571 chr11:113659931 NA -0.71 -7.33 -0.41 2.83e-12 Hip circumference adjusted for BMI; CESC cis rs2204008 0.870 rs12369578 chr12:38444227 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.28 0.53 4.42e-21 Bladder cancer; CESC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg19077165 chr18:44547161 KATNAL2 0.54 7.97 0.44 4.82e-14 Personality dimensions; CESC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg18099408 chr3:52552593 STAB1 -0.32 -5.42 -0.32 1.37e-7 Electroencephalogram traits; CESC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg22307029 chr19:49891270 CCDC155 0.74 8.79 0.48 1.88e-16 Multiple sclerosis; CESC cis rs644799 1.000 rs472231 chr11:95532166 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 13.87 0.65 2.93e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs684232 0.602 rs379998 chr17:556884 A/G cg12384639 chr17:618140 VPS53 0.41 5.23 0.31 3.42e-7 Prostate cancer; CESC cis rs10949834 0.652 rs2269082 chr7:73519875 A/G cg07137043 chr7:73588983 EIF4H -0.69 -7.58 -0.42 5.98e-13 Verbal memory performance (residualized delayed recall change); CESC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.13 -0.3 5.6e-7 Bipolar disorder; CESC cis rs6831352 0.959 rs6532796 chr4:100042242 C/T cg12011299 chr4:100065546 ADH4 -0.69 -8.26 -0.45 6.95e-15 Alcohol dependence; CESC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg12311346 chr5:56204834 C5orf35 -0.73 -8.79 -0.48 1.93e-16 Initial pursuit acceleration; CESC cis rs7940866 0.903 rs1347283 chr11:130868583 T/G cg12179176 chr11:130786555 SNX19 0.61 8.52 0.46 1.21e-15 Schizophrenia; CESC cis rs7829975 0.514 rs2945873 chr8:8260445 C/T cg15556689 chr8:8085844 FLJ10661 0.6 7.84 0.43 1.09e-13 Mood instability; CESC cis rs9910055 0.530 rs7222349 chr17:42304644 C/T cg13607699 chr17:42295918 UBTF 0.83 12.93 0.62 5.67e-30 Total body bone mineral density; CESC cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg10523679 chr1:76189770 ACADM -0.71 -8.24 -0.45 7.75e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.59 7.71 0.43 2.62e-13 Menopause (age at onset); CESC cis rs506597 0.920 rs221786 chr7:100266081 T/C cg10426581 chr7:100472382 SRRT -0.78 -5.55 -0.32 7.07e-8 Pursuit maintenance gain in psychotic disorders; CESC cis rs17854409 0.803 rs1063247 chr20:61472118 C/G cg05147244 chr20:61493195 TCFL5 0.97 6.5 0.37 4e-10 Obesity-related traits; CESC cis rs6582630 0.537 rs2204006 chr12:38407098 A/G cg26384229 chr12:38710491 ALG10B 0.68 10.35 0.54 2.71e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs116095464 0.558 rs9688136 chr5:229348 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.69 0.33 3.34e-8 Breast cancer; CESC cis rs611744 0.647 rs1448150 chr8:109276161 T/C cg21045802 chr8:109455806 TTC35 0.47 5.81 0.34 1.76e-8 Dupuytren's disease; CESC trans rs11644601 1 rs11644601 chr16:15172118 T/C cg04146151 chr16:2155961 PKD1 -0.6 -6.73 -0.38 1.07e-10 Metabolite levels (lipid measures); CESC cis rs1801516 0.948 rs55949629 chr11:108226399 T/C cg04514998 chr11:108680123 DDX10 0.46 5.04 0.3 8.55e-7 Melanoma; CESC cis rs9911578 1.000 rs304292 chr17:56824123 G/A cg05425664 chr17:57184151 TRIM37 -0.49 -6.72 -0.38 1.11e-10 Intelligence (multi-trait analysis); CESC cis rs10905065 0.965 rs7100576 chr10:5784649 G/A cg11519256 chr10:5708881 ASB13 0.44 5.86 0.34 1.36e-8 Menopause (age at onset); CESC cis rs2302190 0.769 rs7215531 chr17:56493374 A/T cg25885038 chr17:56607967 SEPT4 -0.4 -5.15 -0.3 5.03e-7 Vitamin D levels; CESC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg05863683 chr7:1912471 MAD1L1 0.48 7.32 0.41 2.95e-12 Bipolar disorder and schizophrenia; CESC trans rs28549925 0.590 rs17136905 chr7:16985642 T/C cg12639933 chr12:57626296 SHMT2 0.89 6.04 0.35 5.23e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs10465746 0.967 rs7531537 chr1:84414924 C/T cg10977910 chr1:84465055 TTLL7 0.47 6.39 0.37 7.37e-10 Obesity-related traits; CESC cis rs6088580 0.634 rs6059856 chr20:33057954 G/C cg08999081 chr20:33150536 PIGU 0.66 11.67 0.58 1.16e-25 Glomerular filtration rate (creatinine); CESC cis rs11153147 0.730 rs2798646 chr6:109310596 C/A cg05315195 chr6:109294784 ARMC2 0.65 5.95 0.34 8.24e-9 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25421043 chr12:122124840 NA -0.58 -6.85 -0.39 5.08e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18485729 chr3:113774958 QTRTD1;KIAA1407 -0.53 -6.11 -0.35 3.62e-9 Gut microbiome composition (summer); CESC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg26343298 chr8:95960752 TP53INP1 0.37 6.22 0.36 1.91e-9 Type 2 diabetes; CESC cis rs9457247 1.000 rs365189 chr6:167384545 G/A cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.76e-8 Crohn's disease; CESC cis rs2694528 0.686 rs7729781 chr5:59872406 C/T cg11474532 chr5:59995715 DEPDC1B 0.91 6.37 0.36 8.39e-10 Parkinson's disease; CESC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.56 7.97 0.44 4.86e-14 Menopause (age at onset); CESC trans rs7726839 0.540 rs72703083 chr5:595365 C/T cg25482853 chr8:67687455 SGK3 1.04 10.1 0.53 1.69e-20 Obesity-related traits; CESC cis rs9325144 0.560 rs1843910 chr12:38677408 T/C cg26384229 chr12:38710491 ALG10B -0.6 -9.35 -0.5 3.86e-18 Morning vs. evening chronotype; CESC cis rs13064411 0.735 rs6438158 chr3:113217290 C/T cg18753928 chr3:113234510 CCDC52 -0.51 -6.22 -0.36 1.9e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs57709857 0.957 rs6996860 chr8:38243865 G/T cg01506891 chr8:38243824 LETM2 -0.46 -5.1 -0.3 6.42e-7 Autism spectrum disorder or schizophrenia; CESC cis rs11997175 0.583 rs7460295 chr8:33812288 C/T ch.8.33884649F chr8:33765107 NA 0.45 5.69 0.33 3.31e-8 Body mass index; CESC cis rs6991838 0.584 rs7463649 chr8:66485995 C/T cg13398993 chr8:66546079 ARMC1 -0.45 -5.54 -0.32 7.3900000000000007e-08 Intelligence (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25175887 chr12:3274880 TSPAN9 -0.43 -6.49 -0.37 4.26e-10 Gut microbiota (bacterial taxa); CESC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.33 -5.54 -0.32 7.3900000000000007e-08 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs61990749 0.544 rs176979 chr14:78198072 A/C cg23188588 chr14:78226832 SNW1;C14orf178 0.47 5.09 0.3 6.84e-7 Fibroblast growth factor basic levels; CESC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg13798912 chr7:905769 UNC84A 0.52 5.16 0.3 4.86e-7 Cerebrospinal P-tau181p levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg17482706 chr9:77643371 C9orf41 0.48 6.19 0.36 2.25e-9 Systemic lupus erythematosus; CESC cis rs3105593 1.000 rs4775897 chr15:50944066 G/A cg08437265 chr15:50716283 USP8 0.44 5.81 0.34 1.79e-8 QT interval; CESC cis rs2242663 0.798 rs607736 chr11:66328877 G/A cg24851651 chr11:66362959 CCS 0.4 5.16 0.3 4.75e-7 Bipolar disorder; CESC cis rs9815354 0.812 rs73077360 chr3:41850054 C/T cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9911578 1.000 rs8076121 chr17:57041699 G/A cg05425664 chr17:57184151 TRIM37 -0.5 -6.96 -0.39 2.66e-11 Intelligence (multi-trait analysis); CESC cis rs2072732 0.861 rs10489589 chr1:2951244 T/C cg15211996 chr1:2936768 ACTRT2 0.34 5.95 0.34 8.31e-9 Plateletcrit; CESC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg04518342 chr5:131593106 PDLIM4 -0.36 -5.21 -0.3 3.8e-7 Breast cancer; CESC cis rs1364705 1.000 rs61600037 chr8:120225613 T/C cg09273054 chr8:120220131 MAL2 0.52 5.98 0.34 7.35e-9 Hippocampal atrophy; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02760553 chr17:73975121 ACOX1;C17orf106 0.51 6.49 0.37 4.16e-10 Gut microbiota (bacterial taxa); CESC cis rs7640424 0.620 rs71321252 chr3:107813107 A/C cg09227934 chr3:107805635 CD47 -0.45 -5.58 -0.32 5.86e-8 Body mass index; CESC cis rs57221529 0.766 rs17497684 chr5:558307 T/C cg09021430 chr5:549028 NA -0.42 -5.26 -0.31 2.92e-7 Lung disease severity in cystic fibrosis; CESC cis rs920590 0.758 rs62496731 chr8:19659543 C/G cg01411142 chr8:19674711 INTS10 0.53 5.88 0.34 1.22e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg27170947 chr2:26402098 FAM59B 0.82 9.18 0.49 1.23e-17 Gut microbiome composition (summer); CESC cis rs920590 0.758 rs2898491 chr8:19661883 C/T cg03894339 chr8:19674705 INTS10 0.63 7.26 0.41 4.24e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs4566357 0.595 rs10201538 chr2:227914449 A/G cg05526886 chr2:227700861 RHBDD1 -0.45 -5.93 -0.34 9.37e-9 Coronary artery disease; CESC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg12463550 chr7:65579703 CRCP -0.51 -6.5 -0.37 3.9e-10 Aortic root size; CESC trans rs9325144 0.647 rs61930266 chr12:38922048 A/G cg23762105 chr12:34175262 ALG10 0.47 6.17 0.35 2.6e-9 Morning vs. evening chronotype; CESC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg24829409 chr8:58192753 C8orf71 -0.62 -7.16 -0.4 7.75e-12 Developmental language disorder (linguistic errors); CESC cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg03213289 chr20:61660250 NA 0.39 6.06 0.35 4.68e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg23048001 chr7:2026167 MAD1L1 0.48 6.29 0.36 1.33e-9 Bipolar disorder and schizophrenia; CESC cis rs13191362 0.935 rs34587258 chr6:162945580 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.69 5.96 0.34 8.22e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6061231 0.740 rs11698650 chr20:60958374 A/T cg24112000 chr20:60950667 NA -0.55 -8.62 -0.47 6.17e-16 Colorectal cancer; CESC cis rs6439153 0.933 rs6769662 chr3:128721310 A/C cg25356066 chr3:128598488 ACAD9 0.53 6.92 0.39 3.33e-11 Pneumococcal bacteremia; CESC cis rs3020736 0.500 rs5996110 chr22:42493767 A/G cg04733989 chr22:42467013 NAGA -0.79 -12.03 -0.59 6.75e-27 Autism spectrum disorder or schizophrenia; CESC cis rs9303280 0.806 rs9904624 chr17:38036586 A/G cg20243544 chr17:37824526 PNMT 0.5 6.54 0.37 3.21e-10 Self-reported allergy; CESC cis rs4835473 0.897 rs17693768 chr4:144658656 G/A cg25736465 chr4:144833511 NA -0.33 -5.24 -0.31 3.3e-7 Immature fraction of reticulocytes; CESC cis rs67311347 0.955 rs6773383 chr3:40377412 A/T cg24209194 chr3:40518798 ZNF619 0.45 5.87 0.34 1.3e-8 Renal cell carcinoma; CESC cis rs2652822 0.550 rs11853804 chr15:63528256 C/A cg02713581 chr15:63449717 RPS27L 0.49 6.07 0.35 4.47e-9 Metabolic traits; CESC cis rs3862260 0.509 rs3795663 chr1:120165187 G/A cg11530693 chr1:120165357 ZNF697 0.69 10.58 0.55 4.58e-22 Systemic lupus erythematosus; CESC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg04166393 chr7:2884313 GNA12 0.56 7.01 0.4 1.93e-11 Height; CESC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg23161317 chr6:28129485 ZNF389 0.51 6.5 0.37 3.98e-10 Depression; CESC cis rs8077577 0.747 rs62072509 chr17:18182393 G/A cg16794390 chr17:18148240 FLII 0.42 6.58 0.37 2.5e-10 Obesity-related traits; CESC cis rs7165102 1.000 rs7163482 chr15:65739683 C/T cg11441148 chr15:65824328 PTPLAD1 0.31 5.18 0.3 4.29e-7 Mean corpuscular hemoglobin; CESC cis rs6582630 0.519 rs11495376 chr12:38284957 A/C cg13010199 chr12:38710504 ALG10B 0.45 5.65 0.33 4.06e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs36051895 0.530 rs4142064 chr9:5221818 C/T cg02405213 chr9:5042618 JAK2 -0.48 -5.6 -0.33 5.23e-8 Pediatric autoimmune diseases; CESC cis rs2832077 0.527 rs2776210 chr21:30268558 A/G cg03476357 chr21:30257390 N6AMT1 0.41 5.13 0.3 5.56e-7 Cognitive test performance; CESC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg06634786 chr22:41940651 POLR3H 0.69 7.17 0.4 7.68e-12 Vitiligo; CESC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg05368731 chr17:41323189 NBR1 0.79 10.92 0.56 3.52e-23 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18622001 chr10:126150304 LHPP 0.55 6.43 0.37 5.94e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05797093 chr3:58109301 FLNB -0.59 -6.73 -0.38 1.03e-10 Gut microbiome composition (summer); CESC cis rs3126085 1.000 rs3120662 chr1:152302865 G/T cg03465714 chr1:152285911 FLG 0.43 5.22 0.31 3.62e-7 Atopic dermatitis; CESC cis rs4975709 0.569 rs931509 chr5:1858821 A/T cg17650747 chr5:1873721 NA 0.45 6.07 0.35 4.34e-9 Cardiovascular disease risk factors; CESC cis rs7089973 0.604 rs61596353 chr10:116597763 T/C cg23260525 chr10:116636907 FAM160B1 0.4 7.38 0.41 2.03e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs959260 1.000 rs930298 chr17:73404666 T/G cg20590849 chr17:73267439 MIF4GD -0.57 -6.55 -0.37 2.97e-10 Systemic lupus erythematosus; CESC cis rs11764590 0.724 rs62444917 chr7:2107262 A/C cg21782813 chr7:2030301 MAD1L1 -0.4 -5.16 -0.3 4.81e-7 Neuroticism; CESC cis rs13102973 0.965 rs28826933 chr4:135876644 T/A cg14419869 chr4:135874104 NA -0.37 -5.7 -0.33 3.19e-8 Subjective well-being; CESC cis rs9309473 1.000 rs9653557 chr2:73795962 A/C cg20560298 chr2:73613845 ALMS1 -0.55 -7.17 -0.4 7.7e-12 Metabolite levels; CESC cis rs4423214 1.000 rs11600569 chr11:71173747 C/G cg05163923 chr11:71159392 DHCR7 0.79 10.44 0.54 1.35e-21 Vitamin D levels; CESC cis rs7312933 0.703 rs7957471 chr12:42545591 G/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.47 6.02 0.35 5.72e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg21784768 chr11:537496 LRRC56 -0.55 -5.21 -0.3 3.76e-7 Body mass index; CESC cis rs9303401 0.659 rs34382037 chr17:56643550 G/T cg02118635 chr17:56770003 RAD51C;TEX14 1.02 12.93 0.62 5.59e-30 Cognitive test performance; CESC trans rs11624776 1.000 rs11624776 chr14:93595591 A/C cg24799795 chr11:5959658 NA -0.37 -6.0 -0.35 6.43e-9 Migraine;Thyroid hormone levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03241502 chr19:7505149 ARHGEF18 0.48 6.25 0.36 1.67e-9 Fibrinogen levels; CESC cis rs2228479 0.850 rs11641552 chr16:89838700 C/A cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs1256061 0.603 rs1152579 chr14:64695087 A/G cg21174375 chr14:64681225 SYNE2 0.49 6.47 0.37 4.73e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs113835537 0.529 rs17495838 chr11:66196265 T/C cg22134325 chr11:66188745 NPAS4 0.47 6.97 0.39 2.5e-11 Airway imaging phenotypes; CESC trans rs9650657 0.529 rs10108618 chr8:10953092 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.12 -0.35 3.43e-9 Neuroticism; CESC cis rs73019876 0.869 rs1859093 chr19:22143339 T/G cg11619707 chr19:22235551 ZNF257 -0.27 -5.1 -0.3 6.32e-7 Testicular germ cell tumor; CESC cis rs10078 0.571 rs890973 chr5:471494 T/C cg08916839 chr5:415575 AHRR 0.58 6.76 0.38 8.54e-11 Fat distribution (HIV); CESC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg11663144 chr21:46675770 NA -0.57 -8.81 -0.48 1.66e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11864453 0.713 rs12708926 chr16:72126063 T/C cg01557791 chr16:72042693 DHODH -0.46 -5.92 -0.34 9.98e-9 Fibrinogen levels; CESC cis rs58688157 0.705 rs12803132 chr11:586696 A/G cg02461776 chr11:598696 PHRF1 0.51 5.58 0.32 6.09e-8 Systemic lupus erythematosus; CESC cis rs763014 0.898 rs916414 chr16:632073 C/T cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg21963583 chr11:68658836 MRPL21 0.42 5.88 0.34 1.21e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10979 1.000 rs1416207 chr6:143889275 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs10089 1.000 rs9968597 chr5:127455383 C/G cg19767477 chr5:127420684 SLC12A2 -0.4 -5.47 -0.32 1.04e-7 Ileal carcinoids; CESC cis rs79349575 0.749 rs2270574 chr17:47022270 C/T cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs7512552 0.839 rs12042229 chr1:150447398 A/G cg15654264 chr1:150340011 RPRD2 0.39 5.15 0.3 5.16e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs7818688 1.000 rs28616734 chr8:96021443 C/T cg16049864 chr8:95962084 TP53INP1 0.61 5.77 0.33 2.17e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs3741798 1.000 rs61922028 chr12:12487096 A/C cg08615371 chr12:12503544 MANSC1 0.9 6.56 0.37 2.79e-10 Cerebrospinal fluid biomarker levels; CESC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg23281280 chr6:28129359 ZNF389 0.53 7.06 0.4 1.5e-11 Parkinson's disease; CESC cis rs6542838 0.641 rs4850890 chr2:99535426 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.5 -6.46 -0.37 5e-10 Fear of minor pain; CESC cis rs735396 0.595 rs1169279 chr12:121455873 C/T cg25281562 chr12:121454272 C12orf43 0.55 7.01 0.4 1.93e-11 N-glycan levels; CESC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg26839252 chr6:160211577 TCP1;MRPL18 0.46 5.46 0.32 1.12e-7 Age-related macular degeneration (geographic atrophy); CESC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg07332563 chr6:291687 DUSP22 -0.69 -9.04 -0.49 3.5e-17 Menopause (age at onset); CESC cis rs12579753 0.917 rs12316644 chr12:82205497 C/T cg23701643 chr12:82153290 PPFIA2 0.35 5.24 0.31 3.26e-7 Resting heart rate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg02205746 chr16:2732724 KCTD5 -0.43 -6.15 -0.35 2.91e-9 Fibrinogen levels; CESC cis rs698833 0.962 rs698830 chr2:44730863 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.34 0.31 2.03e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg26516362 chr5:178986906 RUFY1 0.46 7.14 0.4 8.75e-12 Lung cancer; CESC cis rs367943 0.698 rs2115207 chr5:112998285 C/T cg12552261 chr5:112820674 MCC 0.45 5.77 0.33 2.18e-8 Type 2 diabetes; CESC cis rs4705952 1.000 rs4705952 chr5:131839618 A/G cg13365209 chr5:132202351 UQCRQ 0.41 5.31 0.31 2.29e-7 C-reactive protein levels; CESC trans rs35146811 0.695 rs858508 chr7:99821381 C/G cg13215871 chr17:75784724 NA -0.34 -6.39 -0.37 7.46e-10 Coronary artery disease; CESC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg06456125 chr7:65229604 NA -0.4 -5.27 -0.31 2.8e-7 Aortic root size; CESC cis rs7927592 0.513 rs653056 chr11:68203625 T/C cg16797656 chr11:68205561 LRP5 0.63 9.82 0.52 1.27e-19 Total body bone mineral density; CESC cis rs6964587 1.000 rs2188155 chr7:91599825 A/C cg17063962 chr7:91808500 NA 0.57 7.74 0.43 2.11e-13 Breast cancer; CESC cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs9814567 1.000 rs10804632 chr3:134294501 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.41 -5.47 -0.32 1.03e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs644799 1.000 rs11021319 chr11:95523123 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.37 0.5 3.31e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs17384381 1.000 rs12132677 chr1:85879613 A/C cg16011679 chr1:85725395 C1orf52 0.76 7.79 0.43 1.51e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg15145296 chr3:125709740 NA -0.56 -5.91 -0.34 1.06e-8 Blood pressure (smoking interaction); CESC cis rs7527798 0.571 rs12045913 chr1:207844625 A/G cg21110645 chr1:207815933 NA -0.33 -5.75 -0.33 2.4e-8 Erythrocyte sedimentation rate; CESC cis rs4423214 0.921 rs11603330 chr11:71153459 C/A cg24826892 chr11:71159390 DHCR7 0.45 5.32 0.31 2.22e-7 Vitamin D levels; CESC cis rs11723261 0.582 rs4582104 chr4:136942 A/T cg12746427 chr4:53362 ZNF718;ZNF595 0.51 6.82 0.39 6.07e-11 Immune response to smallpox vaccine (IL-6); CESC trans rs17685 0.712 rs59659102 chr7:75710114 G/A cg19862616 chr7:65841803 NCRNA00174 0.83 11.94 0.59 1.36e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs9399135 0.967 rs4142299 chr6:135377186 G/T cg22676075 chr6:135203613 NA 0.52 7.29 0.41 3.61e-12 Red blood cell count; CESC cis rs2857078 0.720 rs9906669 chr17:42305706 A/G cg13607699 chr17:42295918 UBTF 0.78 11.36 0.57 1.25e-24 Red cell distribution width;Reticulocyte count; CESC cis rs854765 0.583 rs9904163 chr17:17830553 C/T cg04398451 chr17:18023971 MYO15A -0.67 -9.6 -0.51 6.42e-19 Total body bone mineral density; CESC cis rs4654899 0.833 rs10127757 chr1:21490045 A/G cg05370193 chr1:21551575 ECE1 0.46 7.11 0.4 1.08e-11 Superior frontal gyrus grey matter volume; CESC cis rs7208859 0.623 rs7208441 chr17:29143863 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.35 0.36 9.2e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg16405210 chr4:1374714 KIAA1530 -0.65 -8.48 -0.46 1.56e-15 Longevity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07835809 chr10:85899104 GHITM -0.57 -6.38 -0.36 7.86e-10 Gut microbiome composition (summer); CESC trans rs941207 0.542 rs12370142 chr12:57184585 G/T cg26462586 chr2:11164677 NA 0.38 6.02 0.35 5.82e-9 Platelet count; CESC cis rs3862030 0.720 rs11595149 chr10:104235978 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.37 -5.1 -0.3 6.39e-7 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg11764359 chr7:65958608 NA 0.47 5.84 0.34 1.53e-8 Calcium levels; CESC cis rs7017914 0.967 rs12680988 chr8:71695890 T/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.42 -5.3 -0.31 2.38e-7 Bone mineral density; CESC cis rs1538970 0.816 rs10789464 chr1:45959102 C/T cg03146154 chr1:46216737 IPP 0.49 5.52 0.32 8.01e-8 Platelet count; CESC cis rs4595586 0.545 rs3914596 chr12:39388538 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.58 0.42 5.91e-13 Morning vs. evening chronotype; CESC cis rs7927592 0.763 rs10896351 chr11:68386896 G/A cg16797656 chr11:68205561 LRP5 0.46 6.77 0.38 8.45e-11 Total body bone mineral density; CESC cis rs8114671 0.836 rs2104083 chr20:33649133 G/A cg24642439 chr20:33292090 TP53INP2 -0.47 -5.71 -0.33 3.09e-8 Height; CESC cis rs3768617 0.903 rs10911251 chr1:183081194 A/C ch.1.3577855R chr1:183094577 LAMC1 0.66 9.4 0.5 2.74e-18 Fuchs's corneal dystrophy; CESC cis rs2985684 1.000 rs3007030 chr14:50086563 C/T cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.46 -5.4 -0.31 1.49e-7 Carotid intima media thickness; CESC cis rs6460942 0.908 rs73677559 chr7:12270819 A/C cg06484146 chr7:12443880 VWDE -0.54 -5.66 -0.33 3.93e-8 Coronary artery disease; CESC cis rs9943753 0.525 rs7952909 chr12:109808573 A/T cg19025524 chr12:109796872 NA 0.48 7.03 0.4 1.71e-11 HDL cholesterol; CESC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg07936489 chr17:37558343 FBXL20 -0.81 -11.96 -0.59 1.17e-26 Glomerular filtration rate (creatinine); CESC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.49 7.21 0.41 5.7e-12 Total body bone mineral density; CESC cis rs12586317 0.582 rs731906 chr14:35604543 C/T cg16230307 chr14:35515116 FAM177A1 0.96 10.35 0.54 2.58e-21 Psoriasis; CESC cis rs4834770 1.000 rs6857641 chr4:120243511 T/C cg09307838 chr4:120376055 NA 0.45 5.39 0.31 1.52e-7 Blood protein levels; CESC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg07308232 chr7:1071921 C7orf50 -0.5 -7.0 -0.39 2.12e-11 Longevity;Endometriosis; CESC cis rs1348850 0.526 rs7588049 chr2:178390778 C/T cg23306229 chr2:178417860 TTC30B -0.77 -6.94 -0.39 3.08e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs1545843 0.537 rs11836792 chr12:84793080 C/T cg03015433 chr16:56623111 MT3 -0.34 -6.12 -0.35 3.37e-9 Major depressive disorder; CESC cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg03467027 chr4:99064603 C4orf37 0.48 5.95 0.34 8.67e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9896933 0.775 rs79299098 chr17:80830944 G/A cg20578329 chr17:80767326 TBCD -0.75 -7.78 -0.43 1.62e-13 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs9443645 0.507 rs9352633 chr6:79462623 C/G cg05283184 chr6:79620031 NA -0.39 -6.1 -0.35 3.68e-9 Intelligence (multi-trait analysis); CESC cis rs2479106 1.000 rs2479106 chr9:126525212 A/G cg16191174 chr9:126692580 DENND1A 0.5 6.98 0.39 2.3e-11 Polycystic ovary syndrome; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13837942 chr14:69260273 ZFP36L1 -0.5 -6.22 -0.36 1.96e-9 Ulcerative colitis; CESC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg11764359 chr7:65958608 NA 0.81 9.93 0.52 5.9e-20 Aortic root size; CESC cis rs2070677 1.000 rs1329149 chr10:135349801 T/C cg20169779 chr10:135381914 SYCE1 0.71 8.48 0.46 1.63e-15 Gout; CESC cis rs6831352 0.734 rs2602857 chr4:100030318 G/A cg12011299 chr4:100065546 ADH4 0.56 6.67 0.38 1.44e-10 Alcohol dependence; CESC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg26769984 chr7:1090371 C7orf50 0.53 6.2 0.36 2.16e-9 Bronchopulmonary dysplasia; CESC cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -6.35 -0.36 9.36e-10 Mood instability; CESC cis rs2070488 0.804 rs4678605 chr3:38444489 T/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.83 13.25 0.63 4.47e-31 Electrocardiographic conduction measures; CESC cis rs9916302 0.904 rs6503519 chr17:37706578 A/G cg00129232 chr17:37814104 STARD3 -0.56 -7.25 -0.41 4.69e-12 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21168982 chr1:28559030 DNAJC8 -0.59 -6.99 -0.39 2.24e-11 Gut microbiome composition (summer); CESC trans rs9949291 0.565 rs10469258 chr18:61362156 C/A cg18704691 chr1:221052468 HLX -0.39 -6.11 -0.35 3.46e-9 Eosinophil percentage of white cells; CESC cis rs3105593 0.965 rs62017203 chr15:50950590 C/T cg08437265 chr15:50716283 USP8 0.42 5.36 0.31 1.85e-7 QT interval; CESC cis rs735539 0.718 rs7985552 chr13:21280738 A/T cg04906043 chr13:21280425 IL17D 0.37 5.34 0.31 2.04e-7 Dental caries; CESC cis rs959260 0.800 rs9895739 chr17:73399916 C/T cg20590849 chr17:73267439 MIF4GD -0.55 -6.39 -0.37 7.49e-10 Systemic lupus erythematosus; CESC cis rs2832191 0.935 rs11910475 chr21:30519702 T/C cg08807101 chr21:30365312 RNF160 -0.64 -8.5 -0.46 1.4e-15 Dental caries; CESC cis rs3859192 0.561 rs12451547 chr17:38181168 T/C cg17467752 chr17:38218738 THRA -0.47 -6.34 -0.36 9.92e-10 White blood cell count; CESC cis rs4237845 0.780 rs3751331 chr12:58290278 G/A cg00677455 chr12:58241039 CTDSP2 0.63 7.68 0.43 3.1400000000000003e-13 Intelligence (multi-trait analysis); CESC cis rs6815814 0.904 rs73236628 chr4:38825443 C/T cg02016764 chr4:38805732 TLR1 -0.58 -6.34 -0.36 9.93e-10 Breast cancer; CESC trans rs7246657 0.882 rs28623164 chr19:37913453 G/A cg01833234 chr11:6592585 DNHD1 0.52 6.0 0.35 6.5e-9 Coronary artery calcification; CESC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg13866156 chr1:1669148 SLC35E2 0.49 6.66 0.38 1.59e-10 Body mass index; CESC cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12579753 0.917 rs11115032 chr12:82205073 T/C cg24719984 chr12:82153464 PPFIA2 -0.33 -5.04 -0.3 8.55e-7 Resting heart rate; CESC cis rs5753618 0.583 rs5753631 chr22:31863022 A/C cg13145458 chr22:31556086 RNF185 -0.49 -5.8 -0.34 1.88e-8 Colorectal cancer; CESC cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg02297831 chr4:17616191 MED28 0.56 7.08 0.4 1.29e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg04414720 chr1:150670196 GOLPH3L 0.57 7.58 0.42 5.74e-13 Melanoma; CESC cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg11752832 chr7:134001865 SLC35B4 0.52 6.77 0.38 8.06e-11 Mean platelet volume; CESC cis rs10276381 0.786 rs740261 chr7:28241276 A/G cg23620719 chr7:28220237 JAZF1 0.7 6.81 0.39 6.66e-11 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09569258 chr4:57844912 POLR2B;C4orf14 0.61 6.97 0.39 2.45e-11 Gut microbiome composition (summer); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg04958252 chr8:87517638 FAM82B 0.47 6.65 0.38 1.64e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs113835537 0.735 rs519380 chr11:66409409 G/A cg22134325 chr11:66188745 NPAS4 0.46 6.63 0.38 1.9e-10 Airway imaging phenotypes; CESC cis rs6540556 0.723 rs10863783 chr1:209889802 T/C cg05527609 chr1:210001259 C1orf107 -0.67 -7.36 -0.41 2.32e-12 Red blood cell count; CESC cis rs116095464 0.558 rs6869925 chr5:264036 A/G cg22857025 chr5:266934 NA -1.3 -18.55 -0.75 8.05e-50 Breast cancer; CESC cis rs7570971 0.617 rs1869829 chr2:135877562 C/T cg07169764 chr2:136633963 MCM6 -0.67 -7.98 -0.44 4.34e-14 Blood metabolite levels;Body mass index;Cholesterol, total; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg10324013 chr2:48809499 STON1-GTF2A1L;STON1 -0.44 -6.07 -0.35 4.34e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs9549367 0.789 rs9549701 chr13:113881752 G/C cg18105134 chr13:113819100 PROZ -0.64 -7.7 -0.43 2.8e-13 Platelet distribution width; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg27657525 chr19:30432971 C19orf2 -0.45 -6.25 -0.36 1.62e-9 Ulcerative colitis; CESC cis rs13064411 0.735 rs722392 chr3:113228294 A/G cg18753928 chr3:113234510 CCDC52 -0.48 -5.72 -0.33 2.92e-8 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs5769765 0.955 rs5769767 chr22:50276909 G/A cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs1801251 1.000 rs283475 chr2:233654381 A/C cg25237894 chr2:233734115 C2orf82 -0.48 -8.5 -0.46 1.35e-15 Coronary artery disease; CESC cis rs7249921 0.833 rs6510469 chr19:35672008 G/T cg15419183 chr19:35660584 FXYD5 0.54 8.15 0.45 1.44e-14 Platelet count; CESC cis rs2979489 0.699 rs7840356 chr8:30406251 G/A cg26383811 chr8:30366931 RBPMS 0.78 9.91 0.52 6.64e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs1348850 0.567 rs3821006 chr2:178537694 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.16 0.4 7.91e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09428623 chr2:68480128 PPP3R1 0.48 6.03 0.35 5.4e-9 Gut microbiota (bacterial taxa); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg11338345 chr3:136052698 NA 0.39 6.08 0.35 4.2e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9549367 0.601 rs558869 chr13:113849932 G/T cg18105134 chr13:113819100 PROZ 0.54 7.14 0.4 9.19e-12 Platelet distribution width; CESC cis rs68092024 0.731 rs793479 chr3:99488232 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.43 -6.78 -0.38 7.81e-11 Cleft lip with or without cleft palate; CESC cis rs9399137 0.507 rs4289677 chr6:135275485 A/G cg24558204 chr6:135376177 HBS1L 0.66 8.77 0.47 2.18e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04229103 chr2:145090268 GTDC1 0.61 6.76 0.38 8.74e-11 Gut microbiome composition (summer); CESC cis rs7188697 0.922 rs37061 chr16:58566671 A/G cg21335942 chr16:58549945 SETD6 0.46 5.37 0.31 1.7e-7 QT interval; CESC cis rs9494145 0.680 rs9389269 chr6:135427159 T/C cg22676075 chr6:135203613 NA 0.46 5.55 0.32 7.04e-8 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CESC cis rs7249142 0.549 rs1858846 chr19:19281187 T/G cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.29 5.21 0.3 3.74e-7 IgG glycosylation; CESC cis rs4481887 0.893 rs4275482 chr1:248473506 T/C cg00666640 chr1:248458726 OR2T12 0.36 6.12 0.35 3.33e-9 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08370718 chr15:49913307 DTWD1;C15orf33 0.57 6.76 0.38 8.52e-11 Gut microbiome composition (summer); CESC cis rs7296418 0.961 rs61955196 chr12:123451018 G/C cg05973401 chr12:123451056 ABCB9 0.58 7.38 0.41 2.04e-12 Platelet count; CESC cis rs34779708 0.966 rs17500582 chr10:35498788 T/A cg04310649 chr10:35416472 CREM -0.52 -6.33 -0.36 1.06e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs7264396 0.635 rs6058355 chr20:34491343 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.23 -0.57 3.44e-24 Total cholesterol levels; CESC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg04546413 chr19:29218101 NA 0.56 7.91 0.44 6.84e-14 Methadone dose in opioid dependence; CESC cis rs2204008 0.743 rs11182052 chr12:38450421 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.84 0.34 1.52e-8 Bladder cancer; CESC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg27125505 chr17:43679177 LOC644172 0.51 6.75 0.38 9.27e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs12599106 0.680 rs34728702 chr16:34896584 A/G cg21548813 chr6:291882 DUSP22 -0.74 -9.91 -0.52 6.8e-20 Menopause (age at onset); CESC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg12463550 chr7:65579703 CRCP 0.48 6.23 0.36 1.86e-9 Aortic root size; CESC cis rs7635838 0.855 rs9816564 chr3:11475297 T/C cg00170343 chr3:11313890 ATG7 0.43 5.71 0.33 2.99e-8 HDL cholesterol; CESC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg14773178 chr5:1868261 NA 0.32 5.78 0.33 2.06e-8 Cardiovascular disease risk factors; CESC cis rs1729951 0.575 rs1682357 chr3:136692009 G/A cg03617693 chr3:136751559 NA 0.39 5.46 0.32 1.08e-7 Neuroticism; CESC trans rs7922314 0.571 rs61865717 chr10:64739190 G/A cg06935979 chr1:232941706 KIAA1383 -0.69 -6.38 -0.36 7.94e-10 Cutaneous psoriasis; CESC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.1 -12.68 -0.61 4e-29 Gut microbiome composition (summer); CESC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg23048001 chr7:2026167 MAD1L1 0.43 5.5 0.32 8.88e-8 Bipolar disorder and schizophrenia; CESC cis rs2228479 0.702 rs62056087 chr16:89920383 C/A cg14709524 chr16:89940631 TCF25 0.88 6.04 0.35 5.27e-9 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15535636 chr19:41284070 RAB4B 0.58 6.55 0.37 3.03e-10 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg18402987 chr7:1209562 NA 0.76 7.55 0.42 7.26e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27381216 chr5:7869428 MTRR;FASTKD3 0.76 8.82 0.48 1.57e-16 Gut microbiome composition (summer); CESC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg08470875 chr2:26401718 FAM59B -0.63 -6.72 -0.38 1.09e-10 Gut microbiome composition (summer); CESC cis rs13191362 0.935 rs34035978 chr6:163165336 G/C cg21926612 chr6:163149169 PACRG;PARK2 0.68 7.28 0.41 3.79e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19855366 chr13:111267979 CARKD 0.53 6.27 0.36 1.47e-9 Gut microbiome composition (summer); CESC cis rs9911578 1.000 rs12940681 chr17:56933622 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 2.94e-7 Intelligence (multi-trait analysis); CESC cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg20476274 chr7:133979776 SLC35B4 0.65 9.44 0.5 2e-18 Mean platelet volume; CESC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg22823121 chr1:150693482 HORMAD1 0.47 6.96 0.39 2.6e-11 Tonsillectomy; CESC trans rs17685 0.671 rs60303271 chr7:75760008 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 12.41 0.61 3.51e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs7264396 0.623 rs78949029 chr20:34384964 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -9.4 -0.5 2.67e-18 Total cholesterol levels; CESC cis rs6912958 1.000 rs9450701 chr6:88173167 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.02 -0.44 3.39e-14 Monocyte percentage of white cells; CESC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg03352830 chr11:487213 PTDSS2 0.67 6.76 0.38 8.54e-11 Body mass index; CESC cis rs2797160 1.000 rs6569435 chr6:125998186 T/C cg05901451 chr6:126070800 HEY2 -0.45 -6.68 -0.38 1.38e-10 Endometrial cancer; CESC cis rs7666738 0.716 rs114187620 chr4:98819534 T/A cg05340658 chr4:99064831 C4orf37 0.73 10.48 0.54 1.02e-21 Colonoscopy-negative controls vs population controls; CESC cis rs7223966 0.621 rs28571160 chr17:61638723 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.47 5.4 0.31 1.48e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7208859 0.623 rs3752019 chr17:29151705 C/T cg13385521 chr17:29058706 SUZ12P 0.75 6.0 0.35 6.29e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs826838 0.616 rs7977357 chr12:38626008 C/G cg26384229 chr12:38710491 ALG10B -0.43 -5.65 -0.33 4.09e-8 Heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05930370 chr1:224545104 CNIH4 0.58 6.05 0.35 4.99e-9 Gut microbiome composition (summer); CESC cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg22875332 chr1:76189707 ACADM -0.63 -6.66 -0.38 1.6e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs28830936 1.000 rs112896623 chr15:42001845 C/T cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.37 -5.39 -0.31 1.54e-7 Diastolic blood pressure; CESC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg02375832 chr11:62437615 C11orf48 0.37 5.46 0.32 1.08e-7 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg07092213 chr7:1199455 ZFAND2A -0.49 -5.33 -0.31 2.15e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7100689 0.516 rs3862532 chr10:82015725 A/C cg00277334 chr10:82204260 NA -0.51 -6.45 -0.37 5.38e-10 Post bronchodilator FEV1; CESC cis rs644148 0.730 rs2686766 chr19:44991595 T/G cg15540054 chr19:45004280 ZNF180 -0.57 -6.05 -0.35 4.92e-9 Personality dimensions; CESC cis rs1348850 0.632 rs12467363 chr2:178502512 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.71 0.43 2.58e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8180040 0.966 rs13064843 chr3:47415467 C/T cg27129171 chr3:47204927 SETD2 0.64 9.85 0.52 1.05e-19 Colorectal cancer; CESC cis rs6580649 1.000 rs6580649 chr12:48410517 A/G cg05342945 chr12:48394962 COL2A1 -0.5 -5.66 -0.33 3.84e-8 Lung cancer; CESC cis rs698813 0.851 rs698807 chr2:44701659 G/C cg04920474 chr2:44395004 PPM1B 0.39 5.06 0.3 7.77e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs548181 0.621 rs2912098 chr11:125528569 C/T cg03464685 chr11:125439445 EI24 0.96 8.11 0.45 1.92e-14 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs208520 0.661 rs4710566 chr6:66848538 G/A cg07460842 chr6:66804631 NA -0.99 -13.5 -0.64 5.96e-32 Exhaled nitric oxide output; CESC trans rs677673 0.904 rs675365 chr20:10480889 T/C cg16021678 chr13:55475951 NA 0.51 6.41 0.37 6.76e-10 Body mass index (change over time) in chronic obstructive pulmonary disease; CESC cis rs8062405 1.000 rs62036622 chr16:28837203 T/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.4 -0.31 1.46e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7264396 0.623 rs2425127 chr20:34332037 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.7 -0.55 1.96e-22 Total cholesterol levels; CESC cis rs2302190 0.882 rs9901693 chr17:56606915 C/T cg25885038 chr17:56607967 SEPT4 -0.42 -5.7 -0.33 3.22e-8 Vitamin D levels; CESC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.01 -0.4 1.97e-11 Total body bone mineral density; CESC cis rs523522 0.962 rs4767902 chr12:120910004 C/T cg12219531 chr12:120966889 COQ5 0.73 9.48 0.5 1.51e-18 High light scatter reticulocyte count; CESC cis rs1538970 0.816 rs12029322 chr1:45970446 C/T cg05343316 chr1:45956843 TESK2 0.93 12.78 0.62 1.91e-29 Platelet count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19244826 chr22:19466934 UFD1L;CDC45L -0.44 -6.12 -0.35 3.32e-9 Gut microbiota (bacterial taxa); CESC trans rs10411161 0.702 rs10414472 chr19:52398597 C/T cg22319618 chr22:45562946 NUP50 -0.6 -6.22 -0.36 1.97e-9 Breast cancer; CESC cis rs854765 0.616 rs8070624 chr17:17843396 G/A cg04398451 chr17:18023971 MYO15A -0.62 -8.25 -0.45 7.27e-15 Total body bone mineral density; CESC cis rs10484885 0.775 rs72919985 chr6:90534641 A/G cg13799429 chr6:90582589 CASP8AP2 -0.76 -7.15 -0.4 8.35e-12 QRS interval (sulfonylurea treatment interaction); CESC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg12756686 chr19:29218302 NA 0.47 6.64 0.38 1.77e-10 Methadone dose in opioid dependence; CESC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg24060327 chr5:131705240 SLC22A5 -0.77 -10.85 -0.55 6.31e-23 Breast cancer; CESC cis rs6088590 0.610 rs6120663 chr20:33081906 A/C cg24642439 chr20:33292090 TP53INP2 -0.63 -8.58 -0.47 7.98e-16 Coronary artery disease; CESC cis rs2688608 0.530 rs71507081 chr10:75493136 G/A cg23231163 chr10:75533350 FUT11 -0.35 -5.27 -0.31 2.81e-7 Inflammatory bowel disease; CESC cis rs11997175 0.511 rs4613957 chr8:33673130 C/T ch.8.33884649F chr8:33765107 NA -0.55 -7.47 -0.42 1.16e-12 Body mass index; CESC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg25072359 chr17:41440525 NA 0.48 7.22 0.41 5.65e-12 Menopause (age at onset); CESC cis rs80130819 0.688 rs7305418 chr12:48586112 A/G cg05342945 chr12:48394962 COL2A1 -0.52 -5.88 -0.34 1.26e-8 Prostate cancer; CESC cis rs1707322 0.752 rs28550303 chr1:46188914 G/T cg05343316 chr1:45956843 TESK2 0.51 6.29 0.36 1.29e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs698833 0.819 rs1372078 chr2:44543389 A/T cg04920474 chr2:44395004 PPM1B -0.37 -5.03 -0.3 9.19e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs10870270 1.000 rs11146354 chr10:133774757 A/G cg26149184 chr10:133730230 NA 0.38 5.14 0.3 5.22e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs12478296 1.000 rs55717005 chr2:243041071 T/A cg06360820 chr2:242988706 NA -0.67 -7.61 -0.42 4.78e-13 Obesity-related traits; CESC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg22903657 chr4:1355424 KIAA1530 -0.37 -5.13 -0.3 5.71e-7 Obesity-related traits; CESC cis rs6933660 0.760 rs6904364 chr6:151754273 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.8 12.3 0.6 7.99e-28 Menarche (age at onset); CESC cis rs4566357 0.615 rs10198406 chr2:227913539 A/G cg05526886 chr2:227700861 RHBDD1 -0.46 -6.15 -0.35 2.88e-9 Coronary artery disease; CESC cis rs11252926 0.770 rs4880736 chr10:680133 C/G cg16386425 chr10:429943 DIP2C -0.46 -5.75 -0.33 2.4e-8 Psychosis in Alzheimer's disease; CESC cis rs1707322 1.000 rs12097799 chr1:46459886 C/A cg03146154 chr1:46216737 IPP 0.75 10.29 0.53 4.13e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs629535 0.814 rs549643 chr8:70062884 C/T cg21567404 chr3:27674614 NA 0.82 9.72 0.51 2.63e-19 Dupuytren's disease; CESC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg10074409 chr1:209979377 IRF6 0.35 5.68 0.33 3.46e-8 Cleft lip with or without cleft palate; CESC cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.11 0.3 6.15e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20217938 chr19:3958344 NA -0.5 -6.14 -0.35 3.03e-9 Gut microbiome composition (summer); CESC cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg10351095 chr21:47802916 PCNT -0.38 -5.09 -0.3 6.71e-7 Testicular germ cell tumor; CESC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg05564831 chr3:52568323 NT5DC2 0.48 7.73 0.43 2.18e-13 Electroencephalogram traits; CESC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg05555928 chr11:63887634 MACROD1 0.56 8.66 0.47 4.68e-16 Platelet count; CESC cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg26597838 chr10:835615 NA 0.7 8.11 0.45 1.9e-14 Eosinophil percentage of granulocytes; CESC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.69 -0.55 2e-22 Alzheimer's disease; CESC trans rs10028773 0.506 rs12374346 chr4:120281705 G/A cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Educational attainment; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00905354 chr6:170059414 WDR27 0.39 6.05 0.35 4.98e-9 Gambling; CESC cis rs4919694 0.901 rs74376228 chr10:104677662 G/C cg04362960 chr10:104952993 NT5C2 0.76 5.99 0.35 6.7e-9 Arsenic metabolism; CESC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg10862848 chr6:42927986 GNMT -0.29 -7.18 -0.4 6.93e-12 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2576037 0.521 rs4986227 chr18:44595031 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.48 -6.06 -0.35 4.77e-9 Personality dimensions; CESC cis rs28735056 0.509 rs4799094 chr18:77621727 T/C cg17174613 chr18:77631625 KCNG2 0.29 5.16 0.3 4.78e-7 Schizophrenia; CESC cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg10523679 chr1:76189770 ACADM -0.65 -6.63 -0.38 1.85e-10 Blood metabolite levels;Acylcarnitine levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11694641 chr12:98987961 SLC25A3 0.47 6.14 0.35 3.07e-9 Gut microbiota (bacterial taxa); CESC cis rs6964587 1.000 rs9690778 chr7:91735299 A/G cg17063962 chr7:91808500 NA 0.56 7.69 0.43 2.96e-13 Breast cancer; CESC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg12564285 chr5:131593104 PDLIM4 0.39 6.15 0.35 2.84e-9 Breast cancer; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22982014 chr19:39322497 ECH1 -0.51 -6.59 -0.38 2.33e-10 Ulcerative colitis; CESC trans rs281288 0.666 rs653749 chr15:47644528 A/G cg00990635 chr19:19745667 GMIP -0.48 -6.22 -0.36 1.93e-9 Positive affect; CESC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg21144161 chr5:423903 AHRR 0.37 5.98 0.34 7.12e-9 Cystic fibrosis severity; CESC cis rs6723226 0.881 rs10181198 chr2:32686582 A/G cg02381751 chr2:32503542 YIPF4 0.83 11.72 0.58 7.51e-26 Intelligence (multi-trait analysis); CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 5.12 0.3 5.75e-7 Electroencephalogram traits; CESC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg26818010 chr10:134567672 INPP5A 0.93 11.51 0.58 4e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs11122272 0.735 rs2790886 chr1:231529491 A/C cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs9815354 0.812 rs10510732 chr3:42007339 C/T cg03022575 chr3:42003672 ULK4 0.7 6.29 0.36 1.3e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs919433 0.929 rs10931779 chr2:198166825 A/G cg10820045 chr2:198174542 NA -0.43 -6.83 -0.39 5.72e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs2228479 0.850 rs17226980 chr16:89825065 G/A cg14709524 chr16:89940631 TCF25 0.91 6.75 0.38 9.34e-11 Skin colour saturation; CESC cis rs7834588 0.523 rs7014483 chr8:63833074 C/A cg20602954 chr8:63776762 NKAIN3 0.3 5.03 0.3 9.14e-7 Response to Vitamin E supplementation; CESC cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg03433033 chr1:76189801 ACADM -0.62 -6.52 -0.37 3.45e-10 Blood metabolite levels;Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09868359 chr21:43230669 PRDM15 -0.56 -6.19 -0.36 2.32e-9 Gut microbiome composition (summer); CESC cis rs11098499 0.954 rs6846442 chr4:120326323 G/A cg24375607 chr4:120327624 NA 0.47 5.89 0.34 1.14e-8 Corneal astigmatism; CESC cis rs478304 0.651 rs11227279 chr11:65495211 G/A cg27068330 chr11:65405492 SIPA1 -0.45 -5.46 -0.32 1.08e-7 Acne (severe); CESC cis rs7044106 0.762 rs10739570 chr9:123381222 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.96 0.34 7.88e-9 Hip circumference adjusted for BMI; CESC cis rs6831352 1.000 rs1126671 chr4:100048414 T/C cg12011299 chr4:100065546 ADH4 0.69 8.43 0.46 2.17e-15 Alcohol dependence; CESC cis rs9486715 0.867 rs9480700 chr6:96965056 A/G cg06623918 chr6:96969491 KIAA0776 0.95 14.61 0.67 7.22e-36 Headache; CESC cis rs6582630 0.593 rs12816835 chr12:38533304 C/T cg26384229 chr12:38710491 ALG10B -0.41 -5.44 -0.32 1.18e-7 Drug-induced liver injury (flucloxacillin); CESC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg26335602 chr6:28129616 ZNF389 0.52 6.84 0.39 5.58e-11 Depression; CESC cis rs2832191 0.935 rs67287920 chr21:30523519 C/A cg24692254 chr21:30365293 RNF160 -0.74 -11.14 -0.56 6.98e-24 Dental caries; CESC cis rs8062405 0.720 rs9926245 chr16:28555706 T/A cg08761264 chr16:28874980 SH2B1 -0.41 -5.05 -0.3 8.41e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs826838 0.900 rs11169301 chr12:39128497 C/A cg26384229 chr12:38710491 ALG10B 0.79 12.71 0.62 3.35e-29 Heart rate; CESC cis rs7259376 0.875 rs9304996 chr19:22486535 A/G cg02657401 chr19:22469223 NA -0.26 -5.32 -0.31 2.19e-7 Menopause (age at onset); CESC cis rs9457247 0.967 rs2015864 chr6:167381476 T/C cg25258033 chr6:167368657 RNASET2 -0.4 -6.07 -0.35 4.52e-9 Crohn's disease; CESC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg16743903 chr16:89593216 SPG7 -0.46 -6.02 -0.35 5.64e-9 Multiple myeloma (IgH translocation); CESC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg04369109 chr6:150039330 LATS1 -0.39 -5.27 -0.31 2.82e-7 Lung cancer; CESC cis rs17401966 1.000 rs12407992 chr1:10311983 A/C cg15208524 chr1:10270712 KIF1B 0.44 5.91 0.34 1.04e-8 Hepatocellular carcinoma; CESC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg23283495 chr1:209979779 IRF6 0.45 5.03 0.3 8.95e-7 Cleft lip with or without cleft palate; CESC cis rs3785574 0.962 rs2727280 chr17:61918082 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 6.92 0.39 3.37e-11 Height; CESC cis rs72781680 0.716 rs6718631 chr2:24036086 A/G cg08917208 chr2:24149416 ATAD2B -0.64 -6.34 -0.36 9.79e-10 Lymphocyte counts; CESC cis rs6570726 0.818 rs9399555 chr6:145877554 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.5 0.37 3.87e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs754466 0.874 rs55910200 chr10:79665173 T/C cg17075019 chr10:79541650 NA -0.76 -9.37 -0.5 3.24e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg12963246 chr6:28129442 ZNF389 0.39 5.88 0.34 1.22e-8 Cardiac Troponin-T levels; CESC cis rs736408 0.677 rs678 chr3:52820981 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.1 0.35 3.66e-9 Bipolar disorder; CESC cis rs7824557 0.628 rs3779891 chr8:11183505 G/A cg21775007 chr8:11205619 TDH 0.54 8.56 0.47 9.54e-16 Retinal vascular caliber; CESC cis rs667920 0.573 rs9682783 chr3:136539689 T/C cg15507776 chr3:136538369 TMEM22 0.79 9.88 0.52 8.41e-20 Coronary artery disease; CESC cis rs7223966 0.961 rs112709843 chr17:61836936 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.53 0.37 3.33e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs4077515 0.874 rs3812560 chr9:139269905 T/C cg14169450 chr9:139327907 INPP5E 0.4 5.76 0.33 2.35e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs2204008 0.807 rs11182461 chr12:38539288 T/C cg26384229 chr12:38710491 ALG10B 0.74 11.17 0.57 5.31e-24 Bladder cancer; CESC cis rs727505 0.789 rs66756015 chr7:124740641 C/A cg23710748 chr7:124431027 NA -0.39 -6.27 -0.36 1.44e-9 Lewy body disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg09685500 chr17:40333380 KCNH4 -0.39 -6.43 -0.37 5.98e-10 Gambling; CESC cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg09035930 chr12:129282057 SLC15A4 0.69 9.2 0.49 1.1e-17 Systemic lupus erythematosus; CESC cis rs2243480 0.708 rs13242216 chr7:65898277 T/C cg12463550 chr7:65579703 CRCP 0.71 5.46 0.32 1.08e-7 Diabetic kidney disease; CESC cis rs67311347 1.000 rs73080137 chr3:40516412 A/G cg09455208 chr3:40491958 NA 0.51 8.7 0.47 3.65e-16 Renal cell carcinoma; CESC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg26338869 chr17:61819248 STRADA -0.66 -8.52 -0.46 1.23e-15 Prudent dietary pattern; CESC cis rs2404602 0.692 rs60658665 chr15:77042508 T/C cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC cis rs1256061 0.603 rs1256036 chr14:64743332 C/T cg21174375 chr14:64681225 SYNE2 0.51 6.77 0.38 8.38e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09311052 chr1:154531418 UBE2Q1 0.47 6.3 0.36 1.2e-9 Gut microbiota (bacterial taxa); CESC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg02375832 chr11:62437615 C11orf48 -0.35 -5.07 -0.3 7.59e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs12477438 0.748 rs6712773 chr2:99585781 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg00149659 chr3:10157352 C3orf10 0.77 9.68 0.51 3.58e-19 Alzheimer's disease; CESC cis rs7726839 0.540 rs57306627 chr5:597643 T/C cg16447950 chr5:562315 NA -0.59 -6.01 -0.35 6.18e-9 Obesity-related traits; CESC cis rs9915657 0.803 rs12449851 chr17:70099002 C/T cg09344028 chr17:70110421 NA -0.38 -7.58 -0.42 5.9e-13 Thyroid hormone levels; CESC cis rs17376456 0.825 rs10078941 chr5:93279029 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.67 5.45 0.32 1.13e-7 Diabetic retinopathy; CESC cis rs9309473 0.607 rs12478346 chr2:73584360 C/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.39 -0.37 7.59e-10 Metabolite levels; CESC cis rs72781680 0.611 rs72781699 chr2:24277709 G/A cg20701182 chr2:24300061 SF3B14 0.93 10.68 0.55 2.27e-22 Lymphocyte counts; CESC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg16325326 chr1:53192061 ZYG11B 0.9 14.71 0.67 3.12e-36 Monocyte count; CESC trans rs561341 1.000 rs510264 chr17:30323414 A/G cg20587970 chr11:113659929 NA -1.48 -19.58 -0.77 2.15e-53 Hip circumference adjusted for BMI; CESC cis rs7605827 0.897 rs13017859 chr2:15537641 T/C cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg22535103 chr8:58192502 C8orf71 -0.76 -9.04 -0.49 3.45e-17 Developmental language disorder (linguistic errors); CESC cis rs7584330 0.554 rs77380873 chr2:238426551 C/T cg14458575 chr2:238380390 NA 0.72 6.82 0.39 6.16e-11 Prostate cancer; CESC cis rs2070997 0.756 rs3808820 chr9:133726956 A/T cg11464064 chr9:133710261 ABL1 0.54 5.83 0.34 1.6e-8 Response to amphetamines; CESC cis rs13095912 1.000 rs13340181 chr3:185325612 T/C cg11274856 chr3:185301563 NA 0.36 5.95 0.34 8.39e-9 Systolic blood pressure; CESC cis rs7089973 0.604 rs10885620 chr10:116630048 A/T cg23260525 chr10:116636907 FAM160B1 0.42 8.21 0.45 1.01e-14 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs11650494 0.908 rs117853079 chr17:47421593 G/C cg08112188 chr17:47440006 ZNF652 1.31 8.51 0.46 1.33e-15 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09701880 chr2:112252254 LOC541471 -0.55 -6.41 -0.37 6.61e-10 Gut microbiome composition (summer); CESC cis rs60871478 0.947 rs62432239 chr7:794576 C/T cg27478167 chr7:817139 HEATR2 -0.5 -6.02 -0.35 5.83e-9 Cerebrospinal P-tau181p levels; CESC cis rs703842 0.616 rs10877024 chr12:58226709 C/T cg02175503 chr12:58329896 NA 0.47 5.87 0.34 1.32e-8 Multiple sclerosis; CESC cis rs3015469 0.724 rs11850340 chr14:51213555 A/G cg26011998 chr14:51135199 SAV1 0.55 6.26 0.36 1.51e-9 Plasma amyloid beta peptide concentrations (ABx-40); CESC cis rs360798 0.512 rs2710642 chr2:63149557 G/A cg17519650 chr2:63277830 OTX1 0.53 6.48 0.37 4.56e-10 Coronary artery disease; CESC cis rs2073300 0.609 rs6137920 chr20:23363436 C/T cg16736954 chr20:23401023 NAPB 0.8 6.09 0.35 3.89e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12277122 chr19:12902277 JUNB 0.56 6.36 0.36 9.03e-10 Gut microbiome composition (summer); CESC cis rs6831352 0.918 rs17218560 chr4:100060794 C/T cg12011299 chr4:100065546 ADH4 0.52 6.19 0.36 2.29e-9 Alcohol dependence; CESC cis rs12477438 0.798 rs2084987 chr2:99587885 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs2710642 0.586 rs6545961 chr2:62814166 A/T cg17519650 chr2:63277830 OTX1 0.43 5.58 0.32 6.03e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs9911578 1.000 rs11079365 chr17:56945430 T/C cg12560992 chr17:57184187 TRIM37 0.94 15.65 0.69 1.5e-39 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.36 0.5 3.44e-18 Menopause (age at onset); CESC cis rs7267979 0.966 rs2261790 chr20:25262789 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.02e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.41 -0.32 1.44e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg00522288 chr12:125625016 AACS -0.33 -5.16 -0.3 4.81e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs7100689 0.577 rs10749550 chr10:82031197 A/G cg00277334 chr10:82204260 NA -0.53 -6.64 -0.38 1.81e-10 Post bronchodilator FEV1; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10122252 chr11:67269539 PITPNM1 -0.42 -6.08 -0.35 4.07e-9 Gut microbiota (bacterial taxa); CESC cis rs10779751 1.000 rs2300092 chr1:11266464 T/C cg08854313 chr1:11322531 MTOR 0.88 13.52 0.64 5.1e-32 Body mass index; CESC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg24881330 chr22:46731750 TRMU 0.84 7.55 0.42 7.21e-13 LDL cholesterol;Cholesterol, total; CESC cis rs2242116 0.932 rs4683301 chr3:46931478 A/T cg02527881 chr3:46936655 PTH1R 0.56 9.47 0.5 1.63e-18 Birth weight; CESC cis rs6088590 1.000 rs910870 chr20:33292893 T/C cg06115741 chr20:33292138 TP53INP2 0.49 5.83 0.34 1.57e-8 Coronary artery disease; CESC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.7 -7.86 -0.43 9.43e-14 Gut microbiome composition (summer); CESC cis rs8072100 0.713 rs4968228 chr17:45497548 T/C cg25173405 chr17:45401733 C17orf57 -0.43 -5.43 -0.32 1.26e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs4568518 0.740 rs11535159 chr7:18010309 T/C cg03009463 chr7:17980271 SNX13 0.47 6.16 0.35 2.72e-9 Measles; CESC cis rs10189230 0.967 rs12990760 chr2:222354725 G/T cg14652038 chr2:222343519 EPHA4 0.34 7.01 0.4 1.99e-11 Urate levels in lean individuals; CESC cis rs7520050 0.778 rs3014238 chr1:46090214 A/G cg06784218 chr1:46089804 CCDC17 -0.34 -6.11 -0.35 3.49e-9 Red blood cell count;Reticulocyte count; CESC cis rs722599 0.748 rs61978932 chr14:75342954 C/T cg08847533 chr14:75593920 NEK9 -0.46 -5.67 -0.33 3.65e-8 IgG glycosylation; CESC cis rs7927592 0.763 rs7119422 chr11:68331154 C/T cg01657329 chr11:68192670 LRP5 0.49 6.63 0.38 1.83e-10 Total body bone mineral density; CESC cis rs12142240 0.698 rs1057535 chr1:46815898 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs12530845 0.887 rs4492299 chr7:135315690 T/G cg23117316 chr7:135346802 PL-5283 -0.48 -5.83 -0.34 1.58e-8 Red blood cell traits; CESC cis rs7605827 0.930 rs4668925 chr2:15703576 C/T cg19274914 chr2:15703543 NA 0.36 6.5 0.37 4.08e-10 Educational attainment (years of education); CESC cis rs5758659 0.623 rs133328 chr22:42408079 T/C cg19513890 chr22:42538836 CYP2D7P1 -0.38 -5.39 -0.31 1.55e-7 Cognitive function; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg07115558 chr19:3029503 TLE2 -0.42 -6.01 -0.35 6.17e-9 Vertical cup-disc ratio; CESC cis rs6696846 0.715 rs61822659 chr1:205142847 G/A cg00857998 chr1:205179979 DSTYK 0.56 7.2 0.4 6.3e-12 Red blood cell count; CESC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg24399712 chr22:39784796 NA -0.83 -11.17 -0.57 5.4e-24 Intelligence (multi-trait analysis); CESC cis rs9814567 0.752 rs9848254 chr3:134330374 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.09 -0.3 6.84e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs668210 0.793 rs619701 chr11:65772080 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.66 -6.55 -0.37 3.06e-10 Cerebrospinal fluid biomarker levels; CESC cis rs2950393 0.929 rs7980835 chr12:57070631 G/A cg05584118 chr12:57595605 LRP1 -0.38 -5.47 -0.32 1.06e-7 Platelet distribution width; CESC cis rs868036 1.000 rs4776974 chr15:68095927 G/A cg08079166 chr15:68083412 MAP2K5 0.44 6.94 0.39 2.94e-11 Restless legs syndrome; CESC cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.39 0.31 1.52e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs9584850 0.540 rs61969457 chr13:99176742 C/T cg20750642 chr13:99100586 FARP1 -0.46 -6.15 -0.35 2.91e-9 Neuroticism; CESC cis rs3008870 1.000 rs2985821 chr1:67403787 G/A cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC cis rs889398 0.771 rs1500337 chr16:69901884 C/T cg09409435 chr16:70099608 PDXDC2 -0.39 -5.09 -0.3 6.67e-7 Body mass index; CESC cis rs7264396 0.635 rs6060709 chr20:34536022 A/G cg17201900 chr20:34330562 RBM39 0.5 5.26 0.31 2.96e-7 Total cholesterol levels; CESC cis rs10838687 0.736 rs1449626 chr11:47290759 A/C cg25783544 chr11:47291846 MADD 0.56 6.52 0.37 3.53e-10 Proinsulin levels; CESC cis rs546131 0.642 rs568529 chr11:34842506 C/A cg06937548 chr11:34938143 PDHX;APIP 0.42 5.06 0.3 8e-7 Lung disease severity in cystic fibrosis; CESC cis rs4865169 0.783 rs7668814 chr4:57825190 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.4 -5.16 -0.3 4.88e-7 Breast cancer; CESC cis rs11098499 0.774 rs73842616 chr4:120290683 G/A cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs765787 0.530 rs12903149 chr15:45539076 G/A cg24006582 chr15:45444508 DUOX1 0.58 6.95 0.39 2.9100000000000002e-11 Uric acid levels; CESC cis rs11723261 0.621 rs11733385 chr4:140461 T/G cg12746427 chr4:53362 ZNF718;ZNF595 0.43 5.11 0.3 6.24e-7 Immune response to smallpox vaccine (IL-6); CESC cis rs11958404 0.932 rs55943686 chr5:157439591 G/C cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs9894429 0.869 rs9748184 chr17:79596280 A/G cg18240062 chr17:79603768 NPLOC4 0.73 10.27 0.53 4.66e-21 Eye color traits; CESC cis rs4595586 0.505 rs12826314 chr12:39379435 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs911555 0.723 rs6575991 chr14:103908433 C/T cg24130564 chr14:104152367 KLC1 0.5 6.5 0.37 4.05e-10 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24083067 chr19:48972665 CYTH2 0.57 6.15 0.35 2.81e-9 Gut microbiome composition (summer); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21893394 chr19:10342123 S1PR2 -0.48 -6.1 -0.35 3.69e-9 Ulcerative colitis; CESC cis rs796364 0.715 rs11688872 chr2:201052418 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -6.05 -0.35 4.99e-9 Schizophrenia; CESC cis rs1008375 0.932 rs4698627 chr4:17605959 T/C cg02297831 chr4:17616191 MED28 0.52 6.61 0.38 2.1e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7617773 0.817 rs6801801 chr3:48326433 T/C cg11946769 chr3:48343235 NME6 0.8 10.77 0.55 1.16e-22 Coronary artery disease; CESC cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg04317338 chr11:64019027 PLCB3 0.47 5.62 0.33 4.95e-8 Platelet count; CESC cis rs9818758 0.607 rs12185979 chr3:49651970 C/G cg00383909 chr3:49044727 WDR6 0.89 5.16 0.3 4.96e-7 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs2243480 1.000 rs778704 chr7:65863467 T/C cg12463550 chr7:65579703 CRCP 0.71 5.49 0.32 9.37e-8 Diabetic kidney disease; CESC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg24562669 chr7:97807699 LMTK2 0.51 7.54 0.42 7.27e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg11764359 chr7:65958608 NA 0.82 9.37 0.5 3.25e-18 Aortic root size; CESC cis rs9486719 0.947 rs12213375 chr6:96902134 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -8.17 -0.45 1.23e-14 Migraine;Coronary artery disease; CESC cis rs2635047 0.967 rs2247784 chr18:44746997 G/A cg24371990 chr18:44770781 NA 0.33 5.21 0.3 3.74e-7 Educational attainment; CESC cis rs9487051 0.714 rs6927569 chr6:109621494 T/C cg21918786 chr6:109611834 NA -0.36 -5.26 -0.31 2.99e-7 Reticulocyte fraction of red cells; CESC cis rs61776719 0.738 rs7555461 chr1:38444749 T/C cg18451016 chr1:38461880 NA -0.5 -7.43 -0.42 1.47e-12 Coronary artery disease; CESC trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21659725 chr3:3221576 CRBN -0.83 -13.62 -0.64 2.29e-32 Intelligence (multi-trait analysis); CESC cis rs524023 0.915 rs531763 chr11:64352063 A/G cg07220939 chr11:64358617 SLC22A12 0.35 5.46 0.32 1.08e-7 Urate levels in obese individuals; CESC cis rs6752107 1.000 rs2289474 chr2:234181848 C/T cg23050873 chr2:234184376 ATG16L1;SCARNA5 0.37 5.58 0.32 5.94e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs7818688 1.000 rs4323442 chr8:96022986 T/C cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.19e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs2243480 1.000 rs7456042 chr7:65299778 T/C cg18252515 chr7:66147081 NA -1.07 -10.28 -0.53 4.28e-21 Diabetic kidney disease; CESC cis rs10927875 0.864 rs12744578 chr1:16173110 A/T cg21385522 chr1:16154831 NA -0.95 -12.46 -0.61 2.25e-28 Dilated cardiomyopathy; CESC cis rs11683229 0.704 rs35881827 chr2:63132482 G/A cg17519650 chr2:63277830 OTX1 -0.66 -5.32 -0.31 2.17e-7 Protein quantitative trait loci; CESC cis rs9611565 0.879 rs5758307 chr22:41750219 A/G cg06481639 chr22:41940642 POLR3H -0.44 -5.08 -0.3 7.18e-7 Vitiligo; CESC cis rs2708240 0.666 rs2708257 chr7:147592449 C/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.37 -6.16 -0.35 2.71e-9 QT interval (drug interaction); CESC cis rs8103278 0.793 rs59093775 chr19:46374037 G/A cg14061069 chr19:46274453 DMPK -0.38 -5.08 -0.3 7.17e-7 Coronary artery disease; CESC cis rs7937682 0.924 rs1784782 chr11:111525764 A/C cg09085632 chr11:111637200 PPP2R1B -0.99 -16.01 -0.7 8.36e-41 Primary sclerosing cholangitis; CESC cis rs11577318 0.853 rs17645 chr1:26646730 A/G cg18121669 chr1:26560928 CCDC21 0.42 5.07 0.3 7.54e-7 Granulocyte percentage of myeloid white cells; CESC cis rs4728302 0.869 rs889826 chr7:133595871 A/G cg10665199 chr7:133106180 EXOC4 0.39 5.51 0.32 8.43e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs9811920 0.638 rs796977 chr3:99549723 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.61 -9.71 -0.51 2.81e-19 Axial length; CESC cis rs2519796 0.531 rs2519109 chr9:136807770 A/G cg13751417 chr9:136814406 VAV2 -0.4 -5.18 -0.3 4.48e-7 Hematocrit;Hemoglobin concentration; CESC cis rs854765 0.534 rs7207461 chr17:17949789 T/G cg16928487 chr17:17741425 SREBF1 0.56 9.25 0.49 7.81e-18 Total body bone mineral density; CESC cis rs11690935 0.550 rs6730085 chr2:172864845 C/A cg13550731 chr2:172543902 DYNC1I2 0.44 6.03 0.35 5.45e-9 Schizophrenia; CESC cis rs6963495 0.799 rs73190201 chr7:105165891 A/C cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC trans rs13394619 0.935 rs6746291 chr2:11728381 T/C cg18984002 chr17:36876514 MLLT6 -0.43 -6.43 -0.37 5.75e-10 Endometriosis; CESC trans rs804280 0.542 rs36100659 chr8:11791653 A/T cg15556689 chr8:8085844 FLJ10661 0.52 6.41 0.37 6.53e-10 Myopia (pathological); CESC cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg19717773 chr7:2847554 GNA12 0.47 6.24 0.36 1.74e-9 Height; CESC cis rs9393777 0.623 rs9358944 chr6:26469875 A/C cg12826209 chr6:26865740 GUSBL1 0.68 7.43 0.42 1.51e-12 Intelligence (multi-trait analysis); CESC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.33 -0.31 2.07e-7 Total body bone mineral density; CESC cis rs9788682 1.000 rs12441354 chr15:78821016 G/A cg06917634 chr15:78832804 PSMA4 -0.55 -6.48 -0.37 4.52e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs12451471 0.529 rs2278620 chr17:78083565 G/A cg06718696 chr17:78121285 EIF4A3 0.81 9.77 0.51 1.84e-19 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs2901656 0.967 rs4916186 chr1:172396020 A/G cg03748243 chr1:172413542 C1orf105;PIGC 0.44 6.41 0.37 6.55e-10 Red cell distribution width;Platelet distribution width; CESC cis rs7191439 0.858 rs8050715 chr16:88780923 C/G cg02389323 chr16:88786976 FAM38A 0.84 7.38 0.41 2.08e-12 Plateletcrit; CESC cis rs9457247 1.000 rs429083 chr6:167383972 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.27e-8 Crohn's disease; CESC cis rs7727544 0.735 rs272867 chr5:131681057 G/A cg24060327 chr5:131705240 SLC22A5 -0.67 -9.0 -0.48 4.57e-17 Blood metabolite levels; CESC cis rs684232 0.602 rs331010 chr17:547124 G/A cg15660573 chr17:549704 VPS53 -0.8 -11.67 -0.58 1.16e-25 Prostate cancer; CESC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.57 0.37 2.61e-10 Bipolar disorder; CESC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg23590916 chr17:43697445 MGC57346 0.65 6.72 0.38 1.12e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2455799 0.593 rs2470544 chr3:15727234 A/G cg16303742 chr3:15540471 COLQ -0.38 -5.8 -0.34 1.88e-8 Mean platelet volume; CESC cis rs9486719 0.857 rs2983897 chr6:97033780 C/T cg06623918 chr6:96969491 KIAA0776 -0.86 -10.06 -0.53 2.27e-20 Migraine;Coronary artery disease; CESC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs7917772 0.503 rs7087665 chr10:104282418 T/C cg22532475 chr10:104410764 TRIM8 -0.33 -5.67 -0.33 3.77e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg10523679 chr1:76189770 ACADM 0.66 7.34 0.41 2.64e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1215050 0.740 rs6855827 chr4:99065706 G/A cg05340658 chr4:99064831 C4orf37 0.59 7.84 0.43 1.12e-13 Waist-to-hip ratio adjusted for body mass index; CESC cis rs561341 0.700 rs2074101 chr17:30228656 G/A cg13647721 chr17:30228624 UTP6 0.83 10.81 0.55 8.66e-23 Hip circumference adjusted for BMI; CESC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 12.83 0.62 1.23e-29 Platelet count; CESC cis rs9911578 1.000 rs1494977 chr17:56863064 C/T cg12560992 chr17:57184187 TRIM37 0.92 15.11 0.68 1.28e-37 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19760249 chr17:79254595 SLC38A10 -0.58 -7.18 -0.4 6.92e-12 Gut microbiome composition (summer); CESC cis rs7582720 1.000 rs72936353 chr2:204070956 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.84 7.17 0.4 7.7e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs4803468 0.967 rs1077856 chr19:41885221 T/C cg14132834 chr19:41945861 ATP5SL -0.6 -7.49 -0.42 1.02e-12 Height; CESC cis rs9894429 0.546 rs9906979 chr17:79608765 A/G cg13777783 chr17:79615861 NA -0.36 -5.83 -0.34 1.62e-8 Eye color traits; CESC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg16325326 chr1:53192061 ZYG11B -1.0 -17.81 -0.74 3.35e-47 Monocyte count; CESC cis rs9611565 0.649 rs738422 chr22:42123399 C/T cg03806693 chr22:41940476 POLR3H 0.76 9.28 0.5 6.17e-18 Vitiligo; CESC cis rs7250872 0.568 rs749109 chr19:1819736 G/A cg10370574 chr19:1840461 REXO1 -0.44 -5.95 -0.34 8.27e-9 Bipolar disorder; CESC cis rs10992471 0.627 rs4744138 chr9:95291909 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.43 -5.06 -0.3 7.72e-7 Visceral adipose tissue/subcutaneous adipose tissue ratio; CESC cis rs4268898 0.662 rs2303292 chr2:24432138 C/T cg08917208 chr2:24149416 ATAD2B 0.55 5.27 0.31 2.89e-7 Asthma; CESC cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg06697600 chr4:7070879 GRPEL1 -0.46 -7.03 -0.4 1.7e-11 Monocyte percentage of white cells; CESC cis rs12477438 0.765 rs7591992 chr2:99668954 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.67 -0.47 4.43e-16 Chronic sinus infection; CESC cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.41 5.81 0.34 1.83e-8 Schizophrenia; CESC trans rs9858213 1 rs9858213 chr3:49731861 G/T cg21659725 chr3:3221576 CRBN -0.55 -6.69 -0.38 1.35e-10 Educational attainment; CESC cis rs10754283 0.967 rs10801761 chr1:90115269 C/T cg21401794 chr1:90099060 LRRC8C 0.7 9.29 0.5 5.98e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg10351095 chr21:47802916 PCNT -0.5 -5.98 -0.34 7.35e-9 Testicular germ cell tumor; CESC cis rs9303401 0.659 rs8074016 chr17:56840587 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.98 12.12 0.6 3.53e-27 Cognitive test performance; CESC cis rs2404602 0.692 rs7169663 chr15:77192843 A/C cg22467129 chr15:76604101 ETFA -0.35 -5.24 -0.31 3.34e-7 Blood metabolite levels; CESC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.41 -0.32 1.44e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs3736485 0.966 rs10467923 chr15:51767265 A/C cg08986416 chr15:51914746 DMXL2 -0.42 -5.32 -0.31 2.23e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9911578 0.967 rs9894274 chr17:56977919 G/A cg05425664 chr17:57184151 TRIM37 -0.5 -6.81 -0.39 6.5500000000000006e-11 Intelligence (multi-trait analysis); CESC cis rs9291683 0.632 rs11734375 chr4:10046298 A/G cg11266682 chr4:10021025 SLC2A9 0.68 13.29 0.63 3.1e-31 Bone mineral density; CESC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg16145915 chr7:1198662 ZFAND2A -0.43 -5.99 -0.35 6.66e-9 Longevity;Endometriosis; CESC cis rs2243480 1.000 rs6964245 chr7:65718717 G/A cg12463550 chr7:65579703 CRCP -0.74 -5.73 -0.33 2.74e-8 Diabetic kidney disease; CESC cis rs9549367 0.826 rs35306827 chr13:113869045 G/A cg00898013 chr13:113819073 PROZ -0.52 -7.3 -0.41 3.38e-12 Platelet distribution width; CESC cis rs66573146 0.901 rs55882710 chr4:7030704 G/A cg12726927 chr4:7941431 AFAP1 -0.88 -5.25 -0.31 3.09e-7 Granulocyte percentage of myeloid white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00722097 chr6:111195976 AMD1 0.51 6.39 0.37 7.4e-10 Gut microbiome composition (summer); CESC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg11764359 chr7:65958608 NA 0.68 8.82 0.48 1.52e-16 Calcium levels; CESC cis rs9815354 0.638 rs17284933 chr3:42029835 T/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs7940866 0.834 rs7939417 chr11:130853832 T/A cg14779329 chr11:130786720 SNX19 0.33 5.1 0.3 6.46e-7 Schizophrenia; CESC cis rs854765 0.654 rs11078400 chr17:17757728 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.43 -5.68 -0.33 3.55e-8 Total body bone mineral density; CESC cis rs61931739 0.500 rs10844844 chr12:34380350 G/T cg19457237 chr12:34500585 NA -0.35 -5.07 -0.3 7.6e-7 Morning vs. evening chronotype; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09593402 chr5:96270297 LNPEP 0.52 6.65 0.38 1.72e-10 Gut microbiota (bacterial taxa); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg06211794 chr20:48330587 B4GALT5 -0.49 -6.78 -0.38 7.97e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10189230 0.868 rs5002064 chr2:222353508 G/A cg14652038 chr2:222343519 EPHA4 0.35 7.22 0.41 5.49e-12 Urate levels in lean individuals; CESC trans rs9325144 0.647 rs61931899 chr12:38892422 A/G cg23762105 chr12:34175262 ALG10 0.47 6.13 0.35 3.2e-9 Morning vs. evening chronotype; CESC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg09365446 chr1:150670422 GOLPH3L 0.4 5.35 0.31 1.89e-7 Melanoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12122041 chr4:3234814 HTT -0.58 -7.13 -0.4 9.57e-12 Gut microbiome composition (summer); CESC cis rs7084402 0.967 rs1649066 chr10:60305916 G/C cg07615347 chr10:60278583 BICC1 0.59 9.34 0.5 4.23e-18 Refractive error; CESC cis rs7953249 0.514 rs1169312 chr12:121441461 G/T cg02403541 chr12:121454288 C12orf43 0.64 9.22 0.49 9.44e-18 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs4891159 0.790 rs9950025 chr18:74113596 C/G cg24786174 chr18:74118243 ZNF516 0.76 12.11 0.6 3.83e-27 Longevity; CESC cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg18904891 chr8:8559673 CLDN23 0.73 8.12 0.45 1.74e-14 Obesity-related traits; CESC trans rs11252926 0.673 rs7096559 chr10:499188 C/T cg00953403 chr17:74099816 EXOC7 0.53 6.71 0.38 1.2e-10 Psychosis in Alzheimer's disease; CESC cis rs9902453 0.904 rs12103671 chr17:28408217 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -8.89 -0.48 9.34e-17 Coffee consumption (cups per day); CESC cis rs7937682 0.889 rs493810 chr11:111491888 G/T cg09085632 chr11:111637200 PPP2R1B -0.95 -14.6 -0.67 8.26e-36 Primary sclerosing cholangitis; CESC cis rs1559088 0.625 rs10411739 chr19:33616327 T/C cg17764715 chr19:33622953 WDR88 0.59 8.53 0.46 1.17e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs4243830 0.737 rs7552172 chr1:6612269 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -8.42 -0.46 2.41e-15 Body mass index; CESC cis rs17023223 0.553 rs11484962 chr1:119725186 G/A cg05756136 chr1:119680316 WARS2 -0.47 -5.69 -0.33 3.34e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.15e-9 Aortic root size; CESC cis rs7301826 0.651 rs10744485 chr12:131298550 A/G cg11011512 chr12:131303247 STX2 0.45 5.48 0.32 9.73e-8 Plasma plasminogen activator levels; CESC cis rs79387448 0.626 rs80256362 chr2:103025501 A/G cg09003973 chr2:102972529 NA 1.0 7.8 0.43 1.41e-13 Gut microbiota (bacterial taxa); CESC cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg02773041 chr1:40204384 PPIE 0.53 7.56 0.42 6.49e-13 Blood protein levels; CESC cis rs11078917 1 rs11078917 chr17:37746359 A/C cg00129232 chr17:37814104 STARD3 -0.69 -9.09 -0.49 2.44e-17 Mean corpuscular volume; CESC cis rs9640161 0.702 rs3735175 chr7:150020457 C/T cg10018233 chr7:150070692 REPIN1 0.45 7.08 0.4 1.3e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg11764359 chr7:65958608 NA 0.73 10.55 0.54 5.73e-22 Aortic root size; CESC cis rs6866344 0.561 rs55974982 chr5:178141421 G/A cg03877680 chr5:178157825 ZNF354A 0.82 10.14 0.53 1.28e-20 Neutrophil percentage of white cells; CESC trans rs74054849 0.850 rs41270289 chr1:15993905 C/T cg06826283 chr7:600452 PRKAR1B 0.74 6.17 0.35 2.55e-9 Alcoholic chronic pancreatitis; CESC cis rs9322193 0.607 rs12209310 chr6:150226018 G/A cg01145232 chr6:150245071 RAET1G 0.53 6.68 0.38 1.36e-10 Lung cancer; CESC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg02951883 chr7:2050386 MAD1L1 0.52 6.99 0.39 2.18e-11 Bipolar disorder and schizophrenia; CESC cis rs2228479 0.850 rs62056068 chr16:89909737 C/T cg00800038 chr16:89945340 TCF25 -0.89 -6.89 -0.39 4.13e-11 Skin colour saturation; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg15921012 chr3:15919793 NA -0.44 -6.02 -0.35 5.87e-9 Post-traumatic stress disorder; CESC cis rs7255436 0.965 rs12981318 chr19:8451430 G/A cg16745616 chr19:8428856 ANGPTL4 -0.36 -5.49 -0.32 9.22e-8 HDL cholesterol; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07031243 chr17:40976230 BECN1 -0.52 -6.27 -0.36 1.44e-9 Ulcerative colitis; CESC cis rs12950390 0.893 rs12325760 chr17:45840886 C/T cg00777063 chr17:45855553 NA -0.41 -6.12 -0.35 3.4e-9 IgG glycosylation; CESC cis rs17253792 0.822 rs75936910 chr14:56149351 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.68 0.33 3.46e-8 Putamen volume; CESC cis rs6714710 0.603 rs11681535 chr2:98488949 G/C cg26665480 chr2:98280029 ACTR1B 0.56 7.86 0.43 9.67e-14 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs829883 0.664 rs829864 chr12:98850195 C/T cg25150519 chr12:98850993 NA 0.87 14.77 0.67 2.01e-36 Colorectal adenoma (advanced); CESC cis rs2404602 0.536 rs7163946 chr15:76766049 C/G cg22467129 chr15:76604101 ETFA -0.38 -5.86 -0.34 1.38e-8 Blood metabolite levels; CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg17372223 chr3:52568218 NT5DC2 0.54 9.29 0.5 5.98e-18 Electroencephalogram traits; CESC cis rs2859741 0.546 rs2102087 chr1:37482849 G/A cg09363841 chr1:37513479 NA -0.49 -7.18 -0.4 6.92e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs7072216 0.770 rs1061115 chr10:100177049 G/A cg26618903 chr10:100175079 PYROXD2 -0.33 -5.06 -0.3 7.97e-7 Metabolite levels; CESC cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg22590775 chr19:49891494 CCDC155 0.46 5.66 0.33 3.96e-8 Multiple sclerosis; CESC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg25767906 chr1:53392781 SCP2 0.42 5.37 0.31 1.7e-7 Monocyte count; CESC cis rs868036 1.000 rs1026736 chr15:68101813 T/C cg08079166 chr15:68083412 MAP2K5 0.44 6.94 0.39 2.94e-11 Restless legs syndrome; CESC cis rs477692 0.673 rs579325 chr10:131363688 C/T cg05714579 chr10:131428358 MGMT 0.41 5.31 0.31 2.29e-7 Response to temozolomide; CESC cis rs992157 0.798 rs10932772 chr2:219177148 C/T cg00012203 chr2:219082015 ARPC2 0.76 10.09 0.53 1.84e-20 Colorectal cancer; CESC trans rs4689592 0.619 rs3796908 chr4:7061378 G/A cg07817883 chr1:32538562 TMEM39B -0.6 -6.66 -0.38 1.62e-10 Monocyte percentage of white cells; CESC cis rs4718428 0.607 rs66954441 chr7:66369209 T/C cg25985355 chr7:65971099 NA -0.34 -5.04 -0.3 8.74e-7 Corneal structure; CESC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg08888203 chr3:10149979 C3orf24 0.51 6.39 0.37 7.29e-10 Alzheimer's disease; CESC cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -9.26 -0.49 7.26e-18 Mean corpuscular volume; CESC cis rs7312933 0.558 rs7305397 chr12:42850058 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.22 0.36 1.93e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs4642101 0.793 rs13320486 chr3:12822069 C/A cg05775895 chr3:12838266 CAND2 0.39 5.93 0.34 9.32e-9 QRS complex (12-leadsum); CESC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg13206674 chr6:150067644 NUP43 0.44 6.37 0.36 8.34e-10 Lung cancer; CESC cis rs4253772 0.938 rs9626814 chr22:46637254 C/T cg09491104 chr22:46646882 C22orf40 -0.46 -6.56 -0.37 2.89e-10 LDL cholesterol;Cholesterol, total; CESC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg05368731 chr17:41323189 NBR1 0.73 9.81 0.52 1.4e-19 Menopause (age at onset); CESC cis rs9788682 0.655 rs578776 chr15:78888400 G/A cg24631222 chr15:78858424 CHRNA5 0.66 7.83 0.43 1.15e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs116095464 0.681 rs10060016 chr5:241100 T/C cg20965017 chr5:231967 SDHA -0.47 -5.38 -0.31 1.65e-7 Breast cancer; CESC cis rs2760061 0.583 rs708118 chr1:228201801 A/G cg02753203 chr1:228287806 NA -0.72 -11.52 -0.58 3.57e-25 Diastolic blood pressure; CESC cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg02297831 chr4:17616191 MED28 0.53 6.55 0.37 3.03e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs36051895 0.632 rs10974969 chr9:5125336 G/A cg02405213 chr9:5042618 JAK2 -0.51 -6.08 -0.35 4.27e-9 Pediatric autoimmune diseases; CESC cis rs72781680 0.848 rs72780199 chr2:24016269 A/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg26668828 chr6:292823 DUSP22 -0.72 -9.61 -0.51 6.02e-19 Menopause (age at onset); CESC cis rs7188861 0.768 rs1794025 chr16:11380945 C/T cg01510278 chr16:11456238 NA 0.33 5.12 0.3 5.81e-7 HDL cholesterol; CESC cis rs6430585 0.583 rs78364332 chr2:136640101 T/C cg07169764 chr2:136633963 MCM6 1.3 20.96 0.79 3.59e-58 Corneal structure; CESC cis rs2425143 1.000 rs1056196 chr20:34327159 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.51 -0.42 9.02e-13 Blood protein levels; CESC trans rs7246657 0.943 rs10420754 chr19:37959372 C/G cg01833234 chr11:6592585 DNHD1 0.52 6.0 0.35 6.5e-9 Coronary artery calcification; CESC cis rs1878931 0.582 rs4785933 chr16:3419741 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.67 8.1 0.45 2.07e-14 Body mass index (adult); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19715471 chr10:13344246 NA 0.54 6.24 0.36 1.72e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.875 rs2814876 chr6:146304030 C/T cg23711669 chr6:146136114 FBXO30 0.89 12.95 0.62 4.73e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs524281 0.861 rs10750778 chr11:65948648 T/C cg14036092 chr11:66035641 RAB1B -0.58 -5.92 -0.34 9.93e-9 Electroencephalogram traits; CESC trans rs2816958 0.708 rs2816972 chr1:200085004 A/G cg16196175 chr7:27289120 NA 0.61 6.13 0.35 3.16e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg05564831 chr3:52568323 NT5DC2 0.46 7.19 0.4 6.63e-12 Intelligence (multi-trait analysis); CESC cis rs116095464 0.510 rs7723883 chr5:270798 T/C cg20965017 chr5:231967 SDHA -0.45 -5.1 -0.3 6.6e-7 Breast cancer; CESC cis rs9908102 0.740 rs55825263 chr17:12905743 G/A cg26162695 chr17:12921313 ELAC2 0.5 5.49 0.32 9.61e-8 Schizophrenia; CESC cis rs7659604 0.540 rs116452657 chr4:122674147 A/G cg19671926 chr4:122722719 EXOSC9 0.53 6.71 0.38 1.2e-10 Type 2 diabetes; CESC cis rs963731 0.649 rs297159 chr2:39328827 C/T cg04010122 chr2:39346883 SOS1 -0.75 -5.53 -0.32 7.73e-8 Corticobasal degeneration; CESC cis rs208520 0.754 rs851594 chr6:66876695 A/G cg07460842 chr6:66804631 NA -1.0 -12.97 -0.62 3.95e-30 Exhaled nitric oxide output; CESC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 13.27 0.63 3.73e-31 Personality dimensions; CESC cis rs9486719 1.000 rs2472888 chr6:96865501 T/C cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs2479106 0.892 rs7849665 chr9:126697865 C/T cg16191174 chr9:126692580 DENND1A 0.51 6.83 0.39 5.88e-11 Polycystic ovary syndrome; CESC cis rs12200560 0.505 rs211179 chr6:97074103 A/G cg06623918 chr6:96969491 KIAA0776 0.52 6.65 0.38 1.71e-10 Coronary heart disease; CESC cis rs1801251 1.000 rs895430 chr2:233725483 C/A cg08000102 chr2:233561755 GIGYF2 -0.7 -9.96 -0.52 4.76e-20 Coronary artery disease; CESC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg13206674 chr6:150067644 NUP43 0.45 6.43 0.37 5.76e-10 Lung cancer; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg09373211 chr1:154193749 C1orf43;UBAP2L 0.48 6.09 0.35 3.89e-9 Breast cancer;Type 2 diabetes; CESC trans rs997295 0.529 rs12592315 chr15:68040266 A/G cg05052335 chr5:130970657 RAPGEF6 0.47 6.12 0.35 3.33e-9 Motion sickness; CESC cis rs6547741 0.904 rs1528403 chr2:27846645 C/G cg27432699 chr2:27873401 GPN1 0.38 5.41 0.32 1.4e-7 Oral cavity cancer; CESC cis rs10871290 0.881 rs4099290 chr16:74468889 A/G cg01733217 chr16:74700730 RFWD3 -0.7 -9.29 -0.5 6.06e-18 Breast cancer; CESC cis rs6089584 0.508 rs6061988 chr20:60626300 C/T cg06108461 chr20:60628389 TAF4 -0.6 -8.04 -0.44 3.01e-14 Body mass index; CESC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg05564831 chr3:52568323 NT5DC2 0.54 9.27 0.49 6.88e-18 Electroencephalogram traits; CESC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg13866156 chr1:1669148 SLC35E2 -0.51 -6.75 -0.38 9.36e-11 Body mass index; CESC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg03180552 chr7:157981849 PTPRN2 0.43 6.84 0.39 5.34e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs2290159 0.615 rs7610956 chr3:12677158 A/G cg23032965 chr3:12705835 RAF1 0.52 5.46 0.32 1.12e-7 Cholesterol, total; CESC cis rs5498 0.809 rs1056538 chr19:10402938 G/A cg10604476 chr19:10403908 ICAM5 0.45 6.36 0.36 8.97e-10 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs17253792 0.822 rs17746106 chr14:56069168 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.77 6.53 0.37 3.27e-10 Putamen volume; CESC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg05373962 chr22:49881684 NA -0.38 -6.54 -0.37 3.16e-10 Monocyte count;Monocyte percentage of white cells; CESC trans rs4942242 1.000 rs9594987 chr13:44230994 C/T cg19169023 chr15:41853346 TYRO3 0.48 7.14 0.4 9.01e-12 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9905704 0.633 rs2531727 chr17:56502264 C/T cg12560992 chr17:57184187 TRIM37 0.59 5.74 0.33 2.54e-8 Testicular germ cell tumor; CESC cis rs3960554 0.867 rs79359354 chr7:75702597 G/A cg17325771 chr7:75508891 RHBDD2 -0.33 -5.06 -0.3 8.03e-7 Eotaxin levels; CESC cis rs116095464 0.764 rs10069197 chr5:230822 G/C cg22496380 chr5:211416 CCDC127 -0.74 -8.65 -0.47 5.2e-16 Breast cancer; CESC cis rs7762018 0.943 rs11546265 chr6:170108363 G/A cg13891659 chr6:170190454 C6orf122;C6orf208 0.54 5.64 0.33 4.46e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs2880765 0.835 rs4280192 chr15:86043020 G/A cg10818794 chr15:86012489 AKAP13 -0.34 -5.27 -0.31 2.77e-7 Coronary artery disease; CESC cis rs709400 0.827 rs2274269 chr14:104029246 G/A cg12935359 chr14:103987150 CKB -0.5 -6.59 -0.38 2.4e-10 Body mass index; CESC cis rs13064411 0.696 rs1486894 chr3:113211513 G/A cg18753928 chr3:113234510 CCDC52 -0.52 -6.31 -0.36 1.17e-9 Response to simvastatin treatment (PCSK9 protein level change); CESC trans rs8056446 0.710 rs8059793 chr16:78189298 A/C cg06134974 chr12:51477539 CSRNP2 0.47 6.26 0.36 1.52e-9 Pulmonary function (smoking interaction); CESC cis rs10751667 1.000 rs7394449 chr11:962190 T/C cg01483505 chr11:975446 AP2A2 0.39 5.27 0.31 2.82e-7 Alzheimer's disease (late onset); CESC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg18758796 chr5:131593413 PDLIM4 0.46 6.24 0.36 1.75e-9 Breast cancer; CESC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg22442454 chr1:209979470 IRF6 0.41 5.26 0.31 3.04e-7 Cleft lip with or without cleft palate; CESC cis rs2933343 1.000 rs1680784 chr3:128644458 A/G cg25356066 chr3:128598488 ACAD9 0.61 7.45 0.42 1.3e-12 IgG glycosylation; CESC cis rs6842047 1.000 rs1877320 chr4:187131279 G/A cg09526685 chr4:187126073 CYP4V2 0.7 5.81 0.34 1.83e-8 Blood protein levels; CESC cis rs2404602 0.692 rs4383105 chr15:77055510 T/C cg26408565 chr15:76604113 ETFA -0.38 -5.52 -0.32 8.03e-8 Blood metabolite levels; CESC cis rs2404602 0.684 rs2454451 chr15:76861461 G/T cg23625390 chr15:77176239 SCAPER 0.41 5.81 0.34 1.83e-8 Blood metabolite levels; CESC cis rs6570726 0.935 rs380883 chr6:145822992 A/G cg05347473 chr6:146136440 FBXO30 0.5 6.58 0.37 2.5e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.830 rs1426672 chr4:98923984 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs3026101 0.671 rs1544399 chr17:5305887 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 5.6 0.33 5.31e-8 Body mass index; CESC cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg25554036 chr4:6271136 WFS1 0.53 8.69 0.47 3.8e-16 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2204008 0.837 rs12581130 chr12:38319387 A/G cg26384229 chr12:38710491 ALG10B 0.66 9.76 0.51 2.04e-19 Bladder cancer; CESC cis rs17253792 0.822 rs2296181 chr14:56107051 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.79 6.04 0.35 5.13e-9 Putamen volume; CESC cis rs35110281 0.616 rs2236666 chr21:45109856 T/C cg04455712 chr21:45112962 RRP1B 0.48 7.19 0.4 6.79e-12 Mean corpuscular volume; CESC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg10074409 chr1:209979377 IRF6 0.35 5.67 0.33 3.73e-8 Cleft lip with or without cleft palate; CESC cis rs9300255 0.602 rs2851435 chr12:123712416 G/A cg00376283 chr12:123451042 ABCB9 0.58 6.36 0.36 8.8e-10 Neutrophil percentage of white cells; CESC cis rs11025559 0.812 rs10766678 chr11:20507180 A/G cg19653624 chr11:20408972 PRMT3 -0.45 -5.08 -0.3 7.09e-7 Pursuit maintenance gain; CESC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.06 -0.4 1.46e-11 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27056175 chr8:141556352 EIF2C2 0.47 6.06 0.35 4.68e-9 Fibrinogen levels; CESC cis rs7824557 0.872 rs1347410 chr8:11111242 G/A cg21775007 chr8:11205619 TDH -0.37 -5.29 -0.31 2.51e-7 Retinal vascular caliber; CESC cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg18196295 chr10:418757 DIP2C 0.51 6.96 0.39 2.68e-11 Psychosis in Alzheimer's disease; CESC cis rs7917772 0.503 rs56397707 chr10:104302693 T/C cg22532475 chr10:104410764 TRIM8 -0.35 -5.97 -0.34 7.47e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6137287 0.668 rs6047255 chr20:21095936 A/G cg13880779 chr20:21376337 NKX2-4 0.33 5.19 0.3 4.18e-7 Height; CESC cis rs6582630 0.502 rs4559747 chr12:38436235 G/A cg13010199 chr12:38710504 ALG10B 0.42 5.55 0.32 6.77e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg03188948 chr7:1209495 NA 0.72 7.77 0.43 1.75e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7264396 0.635 rs6058365 chr20:34508092 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -11.07 -0.56 1.19e-23 Total cholesterol levels; CESC cis rs425277 0.917 rs78609670 chr1:2045886 G/T cg04315214 chr1:2043799 PRKCZ -0.43 -6.01 -0.35 6.26e-9 Height; CESC cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg26874164 chr19:58962979 ZNF324B 0.55 7.66 0.43 3.59e-13 Uric acid clearance; CESC cis rs12900413 0.687 rs28650972 chr15:90311941 C/T cg24249390 chr15:90295951 MESP1 -0.41 -5.57 -0.32 6.32e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs6963495 0.818 rs56251768 chr7:105165591 A/G cg13798780 chr7:105162888 PUS7 0.78 8.06 0.44 2.68e-14 Bipolar disorder (body mass index interaction); CESC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg19592336 chr6:28129416 ZNF389 0.58 7.71 0.43 2.54e-13 Depression; CESC cis rs6598955 0.670 rs6676619 chr1:26539035 T/G cg04990556 chr1:26633338 UBXN11 -0.75 -10.6 -0.55 4.14e-22 Obesity-related traits; CESC cis rs7577696 0.524 rs12991444 chr2:32265125 G/T cg02381751 chr2:32503542 YIPF4 -0.43 -5.15 -0.3 5e-7 Inflammatory biomarkers; CESC cis rs116095464 0.558 rs56127718 chr5:270273 G/T cg10591111 chr5:226296 SDHA -0.52 -6.36 -0.36 8.59e-10 Breast cancer; CESC cis rs8141529 0.748 rs715531 chr22:29282679 A/G cg02153584 chr22:29168773 CCDC117 0.6 7.92 0.44 6.37e-14 Lymphocyte counts; CESC cis rs798554 0.591 rs1713913 chr7:2895627 C/T cg19717773 chr7:2847554 GNA12 -0.49 -7.51 -0.42 9.16e-13 Height; CESC cis rs672059 1.000 rs575474 chr1:183158599 T/C ch.1.3577855R chr1:183094577 LAMC1 0.54 6.97 0.39 2.51e-11 Hypertriglyceridemia; CESC cis rs965513 1.000 rs7021576 chr9:100540541 C/T cg13688889 chr9:100608707 NA -0.6 -8.46 -0.46 1.86e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs5769765 0.874 rs4624 chr22:50281917 A/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs454510 0.726 rs838989 chr1:120182906 G/A cg16322792 chr1:120165303 ZNF697 0.41 6.47 0.37 4.68e-10 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC trans rs9467711 0.606 rs28360517 chr6:26602453 A/G cg06606381 chr12:133084897 FBRSL1 -0.74 -7.14 -0.4 8.79e-12 Autism spectrum disorder or schizophrenia; CESC cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg07697082 chr8:82753677 SNX16 0.38 5.8 0.34 1.85e-8 Diastolic blood pressure; CESC trans rs208520 0.690 rs207107 chr6:66794385 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.83 -0.62 1.2e-29 Exhaled nitric oxide output; CESC cis rs4268898 0.636 rs76172309 chr2:24458911 G/C cg20701182 chr2:24300061 SF3B14 0.64 6.91 0.39 3.56e-11 Asthma; CESC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg22535103 chr8:58192502 C8orf71 -0.74 -8.52 -0.46 1.25e-15 Developmental language disorder (linguistic errors); CESC cis rs7605827 0.930 rs3805103 chr2:15518352 A/G cg19274914 chr2:15703543 NA -0.35 -6.13 -0.35 3.19e-9 Educational attainment (years of education); CESC cis rs1008375 0.966 rs12503540 chr4:17698781 C/G cg02297831 chr4:17616191 MED28 -0.45 -5.33 -0.31 2.06e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg11890956 chr21:40555474 PSMG1 -0.62 -8.65 -0.47 5.07e-16 Menarche (age at onset); CESC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg18904891 chr8:8559673 CLDN23 -0.67 -7.51 -0.42 8.91e-13 Obesity-related traits; CESC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg22535103 chr8:58192502 C8orf71 -1.03 -10.87 -0.56 5.14e-23 Developmental language disorder (linguistic errors); CESC cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg24308560 chr3:49941425 MST1R 0.59 8.45 0.46 1.93e-15 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg05368731 chr17:41323189 NBR1 0.75 9.96 0.52 4.74e-20 Menopause (age at onset); CESC cis rs10791097 0.694 rs10894275 chr11:130756251 C/T cg09137382 chr11:130731461 NA 0.34 5.1 0.3 6.52e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25107717 chr1:94312368 MIR760 -0.45 -6.3 -0.36 1.26e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19436804 chr8:8560866 CLDN23 -0.56 -6.4 -0.37 6.92e-10 Gut microbiome composition (summer); CESC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg26039829 chr8:22132926 PIWIL2 0.37 5.69 0.33 3.29e-8 Hypertriglyceridemia; CESC cis rs4481887 0.927 rs4564179 chr1:248472422 T/C cg00666640 chr1:248458726 OR2T12 0.35 5.93 0.34 9.43e-9 Common traits (Other); CESC trans rs877282 0.898 rs11253341 chr10:765008 G/C cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg18337363 chr3:52569053 NT5DC2 -0.29 -5.13 -0.3 5.58e-7 Bipolar disorder; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21308919 chr4:140619560 MGST2 0.43 6.2 0.36 2.11e-9 Fibrinogen levels; CESC cis rs11122272 0.735 rs2790890 chr1:231514567 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -7.28 -0.41 3.86e-12 Hemoglobin concentration; CESC cis rs11264213 0.681 rs72659694 chr1:36301803 G/A cg27506609 chr1:36549197 TEKT2 0.64 5.24 0.31 3.21e-7 Schizophrenia; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25793566 chr3:196467045 PAK2 -0.44 -6.0 -0.35 6.38e-9 Ulcerative colitis; CESC cis rs651907 0.557 rs35117343 chr3:101445126 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.44 5.64 0.33 4.29e-8 Colorectal cancer; CESC cis rs7264396 0.570 rs1970576 chr20:34336720 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -11.72 -0.58 7.6e-26 Total cholesterol levels; CESC trans rs561341 0.943 rs508566 chr17:30289861 G/C cg20587970 chr11:113659929 NA -1.44 -17.64 -0.73 1.34e-46 Hip circumference adjusted for BMI; CESC cis rs9815354 0.857 rs6796078 chr3:42017820 A/T cg03022575 chr3:42003672 ULK4 -0.48 -5.52 -0.32 8.27e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs10463316 0.963 rs10463315 chr5:150745615 T/A cg03212797 chr5:150827313 SLC36A1 -0.44 -5.24 -0.31 3.34e-7 Metabolite levels (Pyroglutamine); CESC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg22862634 chr11:62369728 EML3;MTA2 0.54 7.73 0.43 2.21e-13 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6032067 0.777 rs73907811 chr20:43801395 T/A cg11264863 chr20:43835661 SEMG1 0.5 5.36 0.31 1.77e-7 Blood protein levels; CESC cis rs2739330 0.791 rs9612520 chr22:24269459 G/T cg24846343 chr22:24311635 DDTL 0.61 10.24 0.53 6.07e-21 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7208859 0.673 rs8077116 chr17:29140162 A/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg16887890 chr2:219745233 WNT10A -0.43 -6.07 -0.35 4.47e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1801251 1.000 rs283468 chr2:233658309 C/T cg08000102 chr2:233561755 GIGYF2 0.68 9.67 0.51 3.76e-19 Coronary artery disease; CESC cis rs3784262 1.000 rs4646640 chr15:58247563 C/G cg12031962 chr15:58353849 ALDH1A2 0.3 5.04 0.3 8.53e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg24675658 chr1:53192096 ZYG11B -0.5 -6.23 -0.36 1.79e-9 Monocyte count; CESC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC trans rs11112613 0.938 rs2374513 chr12:106007300 C/T cg20363022 chr13:111909300 ARHGEF7 0.56 6.17 0.35 2.58e-9 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs3768617 0.510 rs10752904 chr1:183101038 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg25018755 chr22:43506952 BIK 0.6 6.22 0.36 1.89e-9 Diastolic blood pressure; CESC cis rs796364 0.806 rs11694236 chr2:200916230 T/C cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC cis rs761746 0.920 rs5753662 chr22:31901432 G/A cg25791279 chr22:32026902 PISD -0.5 -5.54 -0.32 7.33e-8 Intelligence; CESC cis rs7772486 0.659 rs9376957 chr6:146011064 C/T cg05347473 chr6:146136440 FBXO30 -0.51 -6.55 -0.37 2.92e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg24642844 chr7:1081250 C7orf50 -0.77 -9.41 -0.5 2.48e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4642101 0.512 rs12629892 chr3:12818920 A/G cg24848339 chr3:12840334 CAND2 0.43 6.78 0.38 7.98e-11 QRS complex (12-leadsum); CESC cis rs9815354 0.723 rs12152489 chr3:42060402 T/C cg03022575 chr3:42003672 ULK4 0.76 6.86 0.39 4.88e-11 Pulse pressure;Diastolic blood pressure; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg05041045 chr14:31091339 SCFD1 -0.43 -6.17 -0.35 2.56e-9 Thyroid stimulating hormone; CESC trans rs9325144 0.647 rs7957185 chr12:38909710 G/A cg23762105 chr12:34175262 ALG10 0.46 6.05 0.35 4.99e-9 Morning vs. evening chronotype; CESC cis rs9611565 0.592 rs5751101 chr22:41828111 C/T cg06634786 chr22:41940651 POLR3H 0.71 7.17 0.4 7.54e-12 Vitiligo; CESC cis rs10242455 0.867 rs2687135 chr7:99326309 T/G cg07715041 chr7:99302981 CYP3A7 -0.43 -5.43 -0.32 1.28e-7 Blood metabolite levels; CESC cis rs9300255 0.602 rs1402274 chr12:123686224 T/C cg05973401 chr12:123451056 ABCB9 0.5 5.74 0.33 2.53e-8 Neutrophil percentage of white cells; CESC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.4 -0.31 1.51e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs6460942 0.908 rs78374554 chr7:12242285 G/A cg20607287 chr7:12443886 VWDE -0.62 -6.03 -0.35 5.41e-9 Coronary artery disease; CESC cis rs2243480 0.901 rs2949697 chr7:65464236 A/G cg18252515 chr7:66147081 NA -1.13 -10.9 -0.56 4.18e-23 Diabetic kidney disease; CESC cis rs9314323 0.964 rs2304300 chr8:26249018 G/A cg13160058 chr8:26243215 BNIP3L -0.32 -5.16 -0.3 4.79e-7 Red cell distribution width; CESC cis rs7551222 0.752 rs4951075 chr1:204464446 C/A cg20240347 chr1:204465584 NA -0.27 -5.53 -0.32 7.5e-8 Schizophrenia; CESC cis rs6088580 0.634 rs6141465 chr20:32967314 T/C cg08999081 chr20:33150536 PIGU -0.64 -11.25 -0.57 2.81e-24 Glomerular filtration rate (creatinine); CESC trans rs6794880 0.778 rs78141845 chr3:84417405 C/T cg03554283 chr8:76319451 NA 0.57 6.07 0.35 4.44e-9 Body mass index (joint analysis main effects and smoking interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs7267979 0.934 rs2482913 chr20:25405086 T/A cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -15.41 -0.69 1.07e-38 Liver enzyme levels (alkaline phosphatase); CESC cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg24879335 chr3:133465180 TF 0.46 8.71 0.47 3.36e-16 Iron status biomarkers (transferrin levels); CESC cis rs72945132 0.660 rs67433166 chr11:70121604 T/A cg00319359 chr11:70116639 PPFIA1 0.78 7.78 0.43 1.6e-13 Coronary artery disease; CESC trans rs1005277 0.579 rs1780137 chr10:38501475 C/G cg27523141 chr10:43048294 ZNF37B 0.46 6.02 0.35 5.91e-9 Extrinsic epigenetic age acceleration; CESC trans rs875971 0.929 rs12673810 chr7:65923853 T/A cg26939375 chr7:64535504 NA 0.46 6.0 0.35 6.4e-9 Aortic root size; CESC cis rs9611519 0.531 rs1967708 chr22:41444444 G/C cg03806693 chr22:41940476 POLR3H -0.5 -5.96 -0.34 7.8e-9 Neuroticism; CESC cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg10556349 chr10:835070 NA 0.6 5.71 0.33 3.1e-8 Eosinophil percentage of granulocytes; CESC cis rs12476592 0.571 rs964903 chr2:63741548 C/T cg17519650 chr2:63277830 OTX1 -0.49 -5.51 -0.32 8.61e-8 Childhood ear infection; CESC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg02592271 chr2:27665507 KRTCAP3 -0.3 -5.97 -0.34 7.49e-9 Total body bone mineral density; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04135372 chr2:99061383 INPP4A -0.41 -6.49 -0.37 4.09e-10 Gambling; CESC cis rs1879734 0.731 rs12041221 chr1:54164165 A/G cg23596471 chr1:54105337 GLIS1 0.35 5.58 0.32 5.97e-8 Mitral valve prolapse; CESC cis rs9325144 0.678 rs7315271 chr12:39164731 A/G cg26384229 chr12:38710491 ALG10B -0.52 -7.09 -0.4 1.19e-11 Morning vs. evening chronotype; CESC cis rs6942756 0.876 rs7789697 chr7:129060386 T/A cg02491457 chr7:128862824 NA -0.53 -7.26 -0.41 4.34e-12 White matter hyperintensity burden; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02601626 chr11:889231 CHID1 -0.52 -6.01 -0.35 5.99e-9 Gut microbiome composition (summer); CESC cis rs2688608 0.592 rs10762563 chr10:75524802 C/A cg23231163 chr10:75533350 FUT11 -0.36 -5.5 -0.32 8.89e-8 Inflammatory bowel disease; CESC cis rs9470366 0.545 rs2395655 chr6:36645696 C/T cg08179530 chr6:36648295 CDKN1A -0.77 -13.01 -0.62 3.01e-30 QRS duration; CESC cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg24450063 chr1:156163899 SLC25A44 1.11 23.64 0.82 3.21e-67 Testicular germ cell tumor; CESC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg07507251 chr3:52567010 NT5DC2 0.42 7.37 0.41 2.11e-12 Bipolar disorder; CESC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg08736216 chr1:53307985 ZYG11A -0.44 -7.39 -0.41 1.95e-12 Monocyte count; CESC cis rs2404602 0.692 rs2304920 chr15:76993867 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.11 -0.3 6.27e-7 Blood metabolite levels; CESC cis rs7801375 0.515 rs2058968 chr7:131560452 C/T cg26572488 chr7:132299669 PLXNA4 -0.45 -5.06 -0.3 7.81e-7 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs965469 0.779 rs2236114 chr20:3296040 A/G cg25506879 chr20:3388711 C20orf194 -0.48 -5.23 -0.31 3.4e-7 IFN-related cytopenia; CESC cis rs6541297 0.645 rs4846918 chr1:230300586 A/G cg20703242 chr1:230279135 GALNT2 -0.52 -6.22 -0.36 1.92e-9 Coronary artery disease; CESC cis rs9787249 0.915 rs6664570 chr1:40206298 G/A cg02773041 chr1:40204384 PPIE 0.54 7.74 0.43 2.16e-13 Blood protein levels; CESC trans rs12681287 0.547 rs9942823 chr8:87509177 A/G cg27317242 chr8:23145699 R3HCC1 -0.53 -6.35 -0.36 9.05e-10 Caudate activity during reward; CESC cis rs2820292 0.678 rs4494199 chr1:201884668 C/T cg06775570 chr1:201857621 SHISA4 0.31 5.4 0.31 1.51e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs400736 0.930 rs408320 chr1:8085328 T/C cg25007680 chr1:8021821 PARK7 0.71 10.24 0.53 5.87e-21 Response to antidepressants and depression; CESC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg00769240 chr8:12517080 NA -0.44 -6.02 -0.35 5.7e-9 Blood pressure (smoking interaction); CESC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs910316 0.967 rs4899549 chr14:75647494 G/A cg11812906 chr14:75593930 NEK9 -0.84 -13.44 -0.64 9.06e-32 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18879991 chr6:27861393 HIST1H2AM;HIST1H2BO 0.47 6.14 0.35 3.03e-9 Gut microbiota (bacterial taxa); CESC cis rs2228479 0.702 rs17177891 chr16:89799950 C/T cg06558623 chr16:89946397 TCF25 1.03 8.03 0.44 3.28e-14 Skin colour saturation; CESC cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg04450456 chr4:17643702 FAM184B 0.39 5.57 0.32 6.19e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9287719 0.967 rs4669598 chr2:10757838 T/C cg00105475 chr2:10696890 NA 0.37 5.4 0.31 1.52e-7 Prostate cancer; CESC cis rs7828089 0.935 rs896378 chr8:22262321 T/C cg12081754 chr8:22256438 SLC39A14 0.43 5.84 0.34 1.52e-8 Verbal declarative memory; CESC cis rs1670533 1.000 rs11247971 chr4:1053580 A/G cg27284194 chr4:1044797 NA 0.46 5.86 0.34 1.35e-8 Recombination rate (females); CESC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC trans rs637571 0.522 rs542332 chr11:65744421 C/T cg17712092 chr4:129076599 LARP1B 0.72 9.97 0.52 4.26e-20 Eosinophil percentage of white cells; CESC cis rs9640161 0.711 rs3735170 chr7:150034184 T/C cg10018233 chr7:150070692 REPIN1 0.46 6.86 0.39 4.92e-11 Blood protein levels;Circulating chemerin levels; CESC cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.38 -6.51 -0.37 3.85e-10 Hemoglobin concentration; CESC cis rs8114671 0.562 rs6088640 chr20:33472509 C/T cg06115741 chr20:33292138 TP53INP2 0.48 5.8 0.34 1.91e-8 Height; CESC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg14393609 chr7:65229607 NA 0.54 7.23 0.41 5.3e-12 Calcium levels; CESC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg00149659 chr3:10157352 C3orf10 0.72 8.61 0.47 6.41e-16 Alzheimer's disease; CESC cis rs17253792 0.915 rs28375514 chr14:56179941 G/A cg01858014 chr14:56050164 KTN1 -0.91 -7.03 -0.4 1.8e-11 Putamen volume; CESC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg12463550 chr7:65579703 CRCP 0.48 6.17 0.35 2.6e-9 Aortic root size; CESC cis rs10883723 0.773 rs1326193 chr10:104271674 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.41 0.41 1.65e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs523522 0.962 rs4766969 chr12:120988238 A/G cg27279351 chr12:120934652 DYNLL1 0.68 8.7 0.47 3.47e-16 High light scatter reticulocyte count; CESC cis rs787274 1.000 rs72768411 chr9:115502670 C/A cg13803584 chr9:115635662 SNX30 0.58 5.05 0.3 8.31e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7210086 0.768 rs72849444 chr17:70637805 G/A cg04206342 chr17:70636940 NA -0.31 -5.98 -0.34 7.18e-9 Ulcerative colitis; CESC cis rs4595586 0.525 rs12825567 chr12:39386621 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.32 0.41 3.06e-12 Morning vs. evening chronotype; CESC cis rs9837602 1.000 rs2291494 chr3:99781805 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.5 7.18 0.4 6.88e-12 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17113216 chr4:83821792 THAP9 0.58 6.65 0.38 1.68e-10 Gut microbiome composition (summer); CESC cis rs258324 0.720 rs154663 chr16:89726035 T/C cg04240660 chr16:89714849 CHMP1A 0.55 5.62 0.33 4.93e-8 Height; CESC cis rs1878931 0.597 rs37814 chr16:3455247 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.76 -9.04 -0.49 3.32e-17 Body mass index (adult); CESC cis rs853679 1.000 rs10456362 chr6:28221816 A/G cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL -0.72 -8.17 -0.45 1.24e-14 Depression; CESC cis rs7020830 0.861 rs6476622 chr9:37308049 T/A cg14294708 chr9:37120828 ZCCHC7 1.12 19.76 0.77 4.99e-54 Schizophrenia; CESC cis rs5753618 0.583 rs8138596 chr22:31786961 T/A cg02404636 chr22:31891804 SFI1 0.38 5.15 0.3 5.1e-7 Colorectal cancer; CESC cis rs7264396 0.635 rs6060709 chr20:34536022 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.57 6.99 0.39 2.23e-11 Total cholesterol levels; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00744550 chr2:242609941 ATG4B 0.46 6.51 0.37 3.73e-10 Fibrinogen levels; CESC cis rs17209837 1.000 rs17149641 chr7:87086090 T/C cg00919237 chr7:87102261 ABCB4 -0.5 -5.83 -0.34 1.6e-8 Gallbladder cancer; CESC cis rs9715521 0.900 rs6819160 chr4:59834879 A/G cg11281224 chr4:60001000 NA -0.52 -6.76 -0.38 8.63e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs877282 0.947 rs7475589 chr10:767479 C/G cg22713356 chr15:30763199 NA 1.19 11.74 0.58 6.81e-26 Uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20064231 chr18:74608296 ZNF236 -0.71 -8.15 -0.45 1.42e-14 Gut microbiome composition (summer); CESC cis rs950169 0.579 rs12912716 chr15:84664263 A/T cg17507749 chr15:85114479 UBE2QP1 0.63 6.17 0.35 2.59e-9 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20675196 chr20:2854059 PTPRA 0.58 6.48 0.37 4.48e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7914558 1.000 rs7071373 chr10:104771922 A/G cg04362960 chr10:104952993 NT5C2 0.44 5.84 0.34 1.53e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs644799 0.965 rs3789960 chr11:95509037 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.5 0.5 1.28e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs3733585 0.746 rs4318650 chr4:10016868 T/C cg11266682 chr4:10021025 SLC2A9 0.68 13.13 0.63 1.13e-30 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7568458 0.660 rs6547623 chr2:85801964 T/A cg02493740 chr2:85810744 VAMP5 -0.57 -8.52 -0.46 1.26e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs4891159 0.756 rs8084155 chr18:74134952 A/G cg24786174 chr18:74118243 ZNF516 -0.77 -13.18 -0.63 7.72e-31 Longevity; CESC cis rs61931739 0.500 rs7489130 chr12:34539674 C/A cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC cis rs6032067 0.929 rs876835 chr20:43827241 T/C cg10761708 chr20:43804764 PI3 0.53 6.36 0.36 8.83e-10 Blood protein levels; CESC cis rs6912958 0.559 rs451829 chr6:88041919 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.74 11.38 0.57 1.11e-24 Monocyte percentage of white cells; CESC cis rs6088580 0.634 rs6059897 chr20:33113224 A/G cg24642439 chr20:33292090 TP53INP2 0.5 6.55 0.37 2.92e-10 Glomerular filtration rate (creatinine); CESC cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg13880726 chr7:1868755 MAD1L1 -0.5 -5.25 -0.31 3.06e-7 Bipolar disorder; CESC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg05340658 chr4:99064831 C4orf37 0.64 8.35 0.46 3.77e-15 Colonoscopy-negative controls vs population controls; CESC cis rs12220238 1.000 rs11000922 chr10:75969305 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.03 0.3 9.09e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg12463550 chr7:65579703 CRCP 0.56 7.28 0.41 3.73e-12 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22458401 chr7:72742115 TRIM50;FKBP6 -0.51 -6.59 -0.38 2.33e-10 Gut microbiome composition (summer); CESC trans rs208520 0.545 rs10944874 chr6:66752080 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -18.67 -0.75 3.17e-50 Exhaled nitric oxide output; CESC cis rs10129255 0.500 rs1024350 chr14:107141122 C/T cg07958169 chr14:107095056 NA -0.52 -8.4 -0.46 2.68e-15 Kawasaki disease; CESC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg11235426 chr6:292522 DUSP22 -0.73 -9.82 -0.52 1.27e-19 Menopause (age at onset); CESC cis rs3747547 0.818 rs7859715 chr9:37948322 A/C cg13774184 chr9:37916125 SHB -0.61 -6.22 -0.36 1.92e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs7918232 0.941 rs788210 chr10:27476948 T/C cg14240646 chr10:27532245 ACBD5 0.64 6.11 0.35 3.46e-9 Breast cancer; CESC cis rs365132 0.875 rs547798 chr5:176326721 C/A cg16309518 chr5:176445507 NA -0.38 -5.54 -0.32 7.31e-8 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg09359103 chr1:154839909 KCNN3 -0.69 -13.74 -0.65 8.09e-33 Prostate cancer; CESC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg06221963 chr1:154839813 KCNN3 -0.64 -11.23 -0.57 3.53e-24 Prostate cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16071359 chr2:169312933 LASS6 -0.46 -6.58 -0.37 2.57e-10 Gambling; CESC cis rs959260 1.000 rs930299 chr17:73404668 A/C cg20590849 chr17:73267439 MIF4GD -0.57 -6.55 -0.37 2.97e-10 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03383472 chr7:2314947 SNX8 -0.56 -6.23 -0.36 1.8e-9 Gut microbiome composition (summer); CESC trans rs11945798 1.000 rs16887512 chr4:12734271 C/T cg22784836 chr11:1219516 NA 0.55 6.19 0.36 2.24e-9 Word reading; CESC cis rs7086627 0.515 rs7078254 chr10:82212193 C/T cg03267442 chr10:82210566 NA -0.34 -5.57 -0.32 6.21e-8 Post bronchodilator FEV1; CESC cis rs28386778 0.965 rs2854154 chr17:61981696 C/A cg07677032 chr17:61819896 STRADA -0.44 -5.71 -0.33 2.99e-8 Prudent dietary pattern; CESC cis rs6967414 0.605 rs7786706 chr7:6747267 C/T cg09896999 chr7:6746977 ZNF12 -0.44 -6.31 -0.36 1.16e-9 Hematocrit;Hemoglobin concentration; CESC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg27297192 chr10:134578999 INPP5A 0.42 5.47 0.32 1.02e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs3784262 1.000 rs3784262 chr15:58253106 T/C cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.19 -0.3 4.29e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs2281845 0.533 rs10753891 chr1:201100482 A/G cg06714761 chr1:201096289 NA 0.32 5.72 0.33 2.85e-8 Permanent tooth development; CESC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs2735413 0.750 rs75500355 chr16:78075396 A/T cg04733911 chr16:78082701 NA 0.4 5.25 0.31 3.07e-7 Systolic blood pressure (alcohol consumption interaction); CESC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs12618769 0.597 rs55900716 chr2:99109132 G/A cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs35110281 0.805 rs4818855 chr21:45038951 C/T cg01579765 chr21:45077557 HSF2BP -0.52 -8.9 -0.48 8.79e-17 Mean corpuscular volume; CESC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.76 0.65 7.41e-33 Prudent dietary pattern; CESC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg25319279 chr11:5960081 NA 0.38 5.41 0.32 1.41e-7 DNA methylation (variation); CESC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg22907277 chr7:1156413 C7orf50 0.44 6.27 0.36 1.43e-9 Longevity;Endometriosis; CESC cis rs2625529 0.668 rs8192386 chr15:72513148 A/C cg16672083 chr15:72433130 SENP8 0.39 5.06 0.3 7.84e-7 Red blood cell count; CESC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.54 -0.32 7.11e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs4481887 0.893 rs7515080 chr1:248494073 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.71 0.38 1.17e-10 Common traits (Other); CESC cis rs11719291 0.504 rs71324924 chr3:48865444 G/A cg00383909 chr3:49044727 WDR6 0.92 6.66 0.38 1.62e-10 Cognitive function; CESC cis rs780094 0.606 rs6729709 chr2:27583156 G/A cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.39 -0.31 1.57e-7 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs3820928 1.000 rs7561378 chr2:227772248 T/C cg05526886 chr2:227700861 RHBDD1 -0.42 -5.54 -0.32 7.19e-8 Pulmonary function; CESC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg10862848 chr6:42927986 GNMT -0.3 -7.8 -0.43 1.44e-13 Alzheimer's disease in APOE e4+ carriers; CESC cis rs6815814 0.731 rs10776483 chr4:38775040 A/G cg02016764 chr4:38805732 TLR1 -0.44 -6.08 -0.35 4.24e-9 Breast cancer; CESC trans rs4927850 0.957 rs4927851 chr3:195751853 A/G cg16724585 chr3:197361211 NA -0.56 -7.17 -0.4 7.33e-12 Pancreatic cancer; CESC cis rs1551570 0.819 rs11666402 chr19:10219076 A/G cg00593900 chr19:10206746 ANGPTL6 0.32 5.42 0.32 1.33e-7 Narcolepsy; CESC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs7086627 0.515 rs11202957 chr10:82209592 A/G cg03267442 chr10:82210566 NA -0.34 -5.6 -0.33 5.45e-8 Post bronchodilator FEV1; CESC cis rs8050907 0.590 rs17883666 chr16:4550153 G/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.8 5.41 0.32 1.44e-7 Obesity-related traits; CESC trans rs13098911 0.540 rs36122610 chr3:46022833 G/A cg10236987 chr1:228114221 WNT9A 0.6 6.17 0.35 2.61e-9 Celiac disease; CESC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg25072359 chr17:41440525 NA 0.51 6.83 0.39 5.9e-11 Menopause (age at onset); CESC cis rs28374715 0.528 rs28492932 chr15:41624397 G/C cg02330683 chr15:41787940 ITPKA 0.49 5.77 0.33 2.23e-8 Ulcerative colitis; CESC cis rs7523875 0.516 rs6682599 chr1:211522427 G/A cg26515805 chr1:211431828 RCOR3 0.38 5.23 0.31 3.49e-7 Mean corpuscular volume; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06219926 chr3:196669402 NCBP2;LOC152217 -0.44 -6.49 -0.37 4.09e-10 Gambling; CESC cis rs117623576 0.680 rs12269122 chr10:32367864 C/T cg03047570 chr10:32398778 NA -0.62 -6.74 -0.38 9.86e-11 Anti-saccade response; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg11328405 chr15:49170157 SHC4;EID1 -0.41 -6.05 -0.35 4.95e-9 Vertical cup-disc ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26806188 chr12:108908720 FICD 0.6 6.27 0.36 1.47e-9 Gut microbiome composition (summer); CESC cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg02487422 chr3:49467188 NICN1 0.45 5.69 0.33 3.32e-8 Parkinson's disease; CESC cis rs8114671 0.585 rs2236271 chr20:33523840 G/T cg07148914 chr20:33460835 GGT7 -0.49 -6.22 -0.36 1.92e-9 Height; CESC cis rs1215050 0.791 rs165247 chr4:98692399 A/G cg05340658 chr4:99064831 C4orf37 0.49 6.33 0.36 1.02e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg16447950 chr5:562315 NA -0.71 -7.83 -0.43 1.2e-13 Lung disease severity in cystic fibrosis; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg09068198 chr2:65357064 RAB1A -0.56 -6.4 -0.37 6.88e-10 Subjective well-being; CESC cis rs12541635 0.966 rs62527363 chr8:107024258 A/G cg10147462 chr8:107024639 NA 0.42 6.04 0.35 5.06e-9 Age of smoking initiation; CESC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg17372223 chr3:52568218 NT5DC2 0.43 6.37 0.36 8.33e-10 Bipolar disorder; CESC cis rs6570726 0.791 rs1509214 chr6:145784606 A/C cg05347473 chr6:146136440 FBXO30 -0.51 -6.3 -0.36 1.23e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg22467129 chr15:76604101 ETFA -0.4 -5.97 -0.34 7.64e-9 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05043431 chr1:229406934 RAB4A 0.61 7.02 0.4 1.86e-11 Gut microbiome composition (summer); CESC cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg11812906 chr14:75593930 NEK9 -0.9 -14.84 -0.67 1.12e-36 Height; CESC trans rs10743315 0.557 rs74669613 chr12:19313696 T/C cg09562322 chr12:119419143 SRRM4 -0.47 -6.08 -0.35 4.07e-9 Gut microbiota (bacterial taxa); CESC cis rs4664308 0.837 rs56172865 chr2:160967333 C/T cg03641300 chr2:160917029 PLA2R1 -0.64 -9.44 -0.5 2.04e-18 Idiopathic membranous nephropathy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11310629 chr13:45991975 SLC25A30 -0.43 -6.54 -0.37 3.21e-10 Gambling; CESC cis rs4803468 1.000 rs10417311 chr19:41902038 G/A cg14132834 chr19:41945861 ATP5SL -0.65 -8.13 -0.45 1.69e-14 Height; CESC cis rs910316 0.789 rs175444 chr14:75601782 G/C cg11812906 chr14:75593930 NEK9 -0.82 -13.27 -0.63 3.72e-31 Height; CESC trans rs12659622 0.703 rs74655962 chr5:15680745 G/A cg22457238 chr19:58570995 ZNF135 -0.59 -6.41 -0.37 6.65e-10 Obesity-related traits; CESC cis rs72829446 0.530 rs9891297 chr17:7385204 T/C cg02795151 chr17:7402630 POLR2A 0.55 5.86 0.34 1.41e-8 Androgen levels; CESC cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 5.86e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7259965 0.920 rs10853744 chr19:41521939 G/T cg27089200 chr19:41531976 NA 0.35 5.31 0.31 2.31e-7 Midgestational circulating levels of PBDEs;Midgestational circulating levels of organochlorine pesticides; CESC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg18099408 chr3:52552593 STAB1 -0.31 -5.07 -0.3 7.49e-7 Bipolar disorder; CESC cis rs9488822 0.676 rs12154016 chr6:116355188 C/T cg05304507 chr6:116381966 FRK 0.26 6.71 0.38 1.2e-10 Cholesterol, total;LDL cholesterol; CESC cis rs6087990 0.965 rs742630 chr20:31350664 C/G cg13636640 chr20:31349939 DNMT3B 0.93 16.67 0.72 3.77e-43 Ulcerative colitis; CESC cis rs7615952 0.673 rs3811677 chr3:125648080 G/A cg05084668 chr3:125655381 ALG1L -0.51 -5.99 -0.35 6.79e-9 Blood pressure (smoking interaction); CESC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg12310025 chr6:25882481 NA -0.45 -6.74 -0.38 9.75e-11 Intelligence (multi-trait analysis); CESC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg11663144 chr21:46675770 NA -0.61 -9.55 -0.51 9.13e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs35110281 0.782 rs2838329 chr21:45023329 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 6.92 0.39 3.33e-11 Mean corpuscular volume; CESC cis rs34779708 0.931 rs10466072 chr10:35402756 C/T cg04310649 chr10:35416472 CREM -0.54 -6.47 -0.37 4.62e-10 Inflammatory bowel disease;Crohn's disease; CESC trans rs8135828 0.770 rs5763306 chr22:29930578 C/A cg17961835 chr3:126195582 ZXDC -0.45 -6.03 -0.35 5.35e-9 Lipid traits; CESC cis rs2228479 0.681 rs7199685 chr16:89959805 G/C cg04013166 chr16:89971882 TCF25 0.72 8.83 0.48 1.51e-16 Skin colour saturation; CESC cis rs7973683 0.541 rs12309481 chr12:124389150 C/A cg00084347 chr12:124393913 DNAH10 0.28 5.71 0.33 3.09e-8 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs863345 0.604 rs1873509 chr1:158461563 A/G cg12129480 chr1:158549410 OR10X1 0.35 7.07 0.4 1.38e-11 Pneumococcal bacteremia; CESC cis rs2730245 0.550 rs2709860 chr7:158651156 A/T cg01943577 chr7:158741284 NA -0.43 -5.71 -0.33 2.95e-8 Height; CESC cis rs9911578 0.835 rs9904993 chr17:56468569 G/T cg12560992 chr17:57184187 TRIM37 -0.87 -14.29 -0.66 9.86e-35 Intelligence (multi-trait analysis); CESC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg04317338 chr11:64019027 PLCB3 0.9 10.09 0.53 1.82e-20 Mean platelet volume; CESC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg18230493 chr5:56204884 C5orf35 -0.73 -8.89 -0.48 9.77e-17 Initial pursuit acceleration; CESC cis rs55883249 1.000 rs75139639 chr2:9763905 A/T cg23886495 chr2:9695866 ADAM17 0.61 5.51 0.32 8.64e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs910316 0.737 rs175072 chr14:75502827 T/C cg16144293 chr14:75469539 EIF2B2 0.4 5.36 0.31 1.8e-7 Height; CESC cis rs854765 0.583 rs28428991 chr17:17827649 C/T cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.93e-9 Total body bone mineral density; CESC cis rs793571 0.568 rs6494029 chr15:58923206 T/C cg05156742 chr15:59063176 FAM63B 0.75 10.68 0.55 2.23e-22 Schizophrenia; CESC cis rs2708240 1.000 rs7806519 chr7:147574574 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.78 -0.33 2.06e-8 QT interval (drug interaction); CESC cis rs853679 0.766 rs9368561 chr6:28168343 C/T cg18032046 chr6:28092343 ZSCAN16 -0.75 -6.47 -0.37 4.62e-10 Depression; CESC cis rs1165640 0.522 rs554880 chr3:193552879 G/A cg21197336 chr3:193587490 NA -0.49 -5.31 -0.31 2.31e-7 Smoking cessation in chronic obstructive pulmonary disease; CESC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg23985595 chr17:80112537 CCDC57 0.42 6.63 0.38 1.9e-10 Life satisfaction; CESC cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg23711669 chr6:146136114 FBXO30 -0.99 -15.26 -0.68 3.83e-38 Lobe attachment (rater-scored or self-reported); CESC cis rs2841277 0.738 rs1036713 chr14:105396693 C/G cg15352829 chr14:105391018 PLD4 0.4 6.29 0.36 1.33e-9 Rheumatoid arthritis; CESC cis rs2180341 1.000 rs6904520 chr6:127629802 T/C cg27446573 chr6:127587934 RNF146 1.09 16.33 0.71 5.73e-42 Breast cancer; CESC trans rs4689592 0.546 rs10937784 chr4:7060935 G/C cg07817883 chr1:32538562 TMEM39B -0.53 -6.3 -0.36 1.24e-9 Monocyte percentage of white cells; CESC cis rs10129255 0.500 rs2027903 chr14:107215283 A/C cg23076370 chr14:107095027 NA -0.71 -10.98 -0.56 2.23e-23 Kawasaki disease; CESC cis rs992157 0.767 rs2014615 chr2:219171191 A/G cg00012203 chr2:219082015 ARPC2 0.73 9.89 0.52 7.98e-20 Colorectal cancer; CESC cis rs12893668 0.542 rs12884809 chr14:104095320 G/A cg19000871 chr14:103996768 TRMT61A -0.33 -5.09 -0.3 6.69e-7 Reticulocyte count; CESC cis rs2594989 0.837 rs2454497 chr3:11501597 T/C cg00170343 chr3:11313890 ATG7 0.56 5.1 0.3 6.55e-7 Circulating chemerin levels; CESC cis rs7582720 1.000 rs77931721 chr2:203763076 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs1728785 1.000 rs864742 chr16:68575309 T/C cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg20476274 chr7:133979776 SLC35B4 0.65 9.41 0.5 2.53e-18 Mean platelet volume; CESC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.66 9.43 0.5 2.09e-18 Menarche (age at onset); CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg11594892 chr1:150849332 ARNT -0.53 -6.28 -0.36 1.38e-9 Subjective well-being; CESC cis rs9894429 1.000 rs7406003 chr17:79597597 C/T cg13777783 chr17:79615861 NA -0.34 -5.65 -0.33 4.22e-8 Eye color traits; CESC cis rs2652822 0.571 rs62012880 chr15:63527162 A/G cg02713581 chr15:63449717 RPS27L 0.45 5.56 0.32 6.53e-8 Metabolic traits; CESC cis rs35110281 0.687 rs4819284 chr21:45084548 C/T cg01579765 chr21:45077557 HSF2BP -0.48 -8.03 -0.44 3.1e-14 Mean corpuscular volume; CESC cis rs28374715 0.532 rs7164211 chr15:41705041 A/T cg20272979 chr15:41787780 ITPKA 0.44 5.64 0.33 4.34e-8 Ulcerative colitis; CESC cis rs11122272 0.735 rs2739515 chr1:231514681 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs9488822 0.636 rs11153592 chr6:116330574 T/C cg18764771 chr6:116381957 FRK 0.22 5.37 0.31 1.68e-7 Cholesterol, total;LDL cholesterol; CESC cis rs2625529 0.617 rs2128112 chr15:72186286 A/T cg16672083 chr15:72433130 SENP8 0.46 6.79 0.38 7.52e-11 Red blood cell count; CESC cis rs7084402 1.000 rs34774248 chr10:60269691 A/G cg07615347 chr10:60278583 BICC1 -0.57 -8.71 -0.47 3.43e-16 Refractive error; CESC cis rs6120849 0.901 rs6060273 chr20:33744323 G/C cg24642439 chr20:33292090 TP53INP2 0.6 6.4 0.37 6.87e-10 Protein C levels; CESC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg10053473 chr17:62856997 LRRC37A3 0.64 6.98 0.39 2.43e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2522056 0.935 rs757104 chr5:131795229 T/C cg07395648 chr5:131743802 NA 0.44 5.08 0.3 6.96e-7 Lymphocyte counts;Fibrinogen; CESC cis rs4253772 0.938 rs41427746 chr22:46637239 T/C cg24881330 chr22:46731750 TRMU 0.6 5.44 0.32 1.18e-7 LDL cholesterol;Cholesterol, total; CESC cis rs9287719 0.934 rs6727884 chr2:10757557 C/T cg02196655 chr2:10830764 NOL10 0.35 5.35 0.31 1.95e-7 Prostate cancer; CESC cis rs4481887 0.790 rs7546964 chr1:248414960 A/G cg00666640 chr1:248458726 OR2T12 0.34 5.9 0.34 1.08e-8 Common traits (Other); CESC cis rs3785574 0.743 rs2727334 chr17:61969063 A/T cg01411255 chr17:61851458 DDX42;CCDC47 1.03 16.25 0.71 1.1e-41 Height; CESC cis rs1670533 1.000 rs10084849 chr4:1053586 T/C cg04106633 chr4:1044584 NA 0.41 5.2 0.3 3.94e-7 Recombination rate (females); CESC cis rs7107174 0.901 rs2510053 chr11:77959435 T/C cg02023728 chr11:77925099 USP35 0.39 5.69 0.33 3.4e-8 Testicular germ cell tumor; CESC cis rs2404602 0.692 rs57178708 chr15:76904069 T/C cg22467129 chr15:76604101 ETFA -0.36 -5.29 -0.31 2.53e-7 Blood metabolite levels; CESC cis rs6088590 0.687 rs13044899 chr20:33287078 G/A cg24642439 chr20:33292090 TP53INP2 0.66 8.4 0.46 2.74e-15 Coronary artery disease; CESC cis rs1348850 0.918 rs12463893 chr2:178448559 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.41 0.46 2.51e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg06627628 chr2:24431161 ITSN2 0.66 6.25 0.36 1.62e-9 Lymphocyte counts; CESC trans rs877282 0.898 rs12356709 chr10:763365 A/G cg22713356 chr15:30763199 NA 1.16 11.35 0.57 1.37e-24 Uric acid levels; CESC cis rs2933343 0.700 rs789238 chr3:128636715 A/G cg25356066 chr3:128598488 ACAD9 0.58 7.93 0.44 6.33e-14 IgG glycosylation; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12857786 chr4:83934023 LIN54 -0.48 -6.09 -0.35 4.01e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs713587 0.935 rs11676272 chr2:25141538 A/G cg01884057 chr2:25150051 NA 0.42 7.91 0.44 6.96e-14 Body mass index in non-asthmatics; CESC cis rs2635047 0.600 rs2635056 chr18:44710568 G/A cg24371990 chr18:44770781 NA 0.32 5.15 0.3 5.03e-7 Educational attainment; CESC cis rs9583531 0.600 rs9521909 chr13:111362170 A/G cg24331049 chr13:111365604 ING1 0.75 10.98 0.56 2.28e-23 Coronary artery disease; CESC cis rs17095355 0.901 rs9783184 chr10:111760499 T/G cg00817464 chr10:111662876 XPNPEP1 -0.52 -5.99 -0.35 6.73e-9 Biliary atresia; CESC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg18252515 chr7:66147081 NA 0.47 6.17 0.35 2.57e-9 Aortic root size; CESC cis rs1800469 1.000 rs1800469 chr19:41860296 A/G cg08477640 chr19:41863820 B9D2 0.63 8.36 0.46 3.6e-15 Colorectal cancer; CESC cis rs7103648 0.897 rs3758675 chr11:47400602 G/A cg03711944 chr11:47377212 SPI1 -0.39 -6.06 -0.35 4.76e-9 Diastolic blood pressure;Systolic blood pressure; CESC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.28 0.31 2.71e-7 Personality dimensions; CESC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg18402987 chr7:1209562 NA 0.75 7.57 0.42 6.17e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg17294928 chr15:75287854 SCAMP5 -0.73 -8.52 -0.46 1.18e-15 Blood trace element (Zn levels); CESC cis rs2235642 0.893 rs2076445 chr16:1592266 A/T cg07639376 chr16:1584516 IFT140;TMEM204 -0.34 -5.51 -0.32 8.57e-8 Coronary artery disease; CESC cis rs6594499 0.872 rs6859041 chr5:110435231 G/A cg04022379 chr5:110408740 TSLP 0.34 6.2 0.36 2.15e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs739401 0.572 rs12276060 chr11:3015572 A/T cg08508325 chr11:3079039 CARS -0.54 -10.31 -0.53 3.66e-21 Longevity; CESC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.55 0.54 6.12e-22 Prudent dietary pattern; CESC cis rs9549367 0.865 rs9549366 chr13:113907644 G/A cg00898013 chr13:113819073 PROZ -0.52 -7.45 -0.42 1.31e-12 Platelet distribution width; CESC cis rs6987853 0.736 rs35295075 chr8:42428852 A/G cg09913449 chr8:42400586 C8orf40 0.47 7.89 0.44 8.14e-14 Mean corpuscular hemoglobin concentration; CESC cis rs7208859 0.623 rs216423 chr17:28942109 G/C cg14008862 chr17:28927542 LRRC37B2 0.7 6.36 0.36 8.84e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01181084 chr8:43059863 NA -0.56 -6.07 -0.35 4.38e-9 Gut microbiome composition (summer); CESC cis rs35123781 1.000 rs601728 chr5:139057076 T/C cg10513866 chr5:139070639 NA 0.37 5.37 0.31 1.75e-7 Schizophrenia; CESC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.13 22.36 0.81 6.07e-63 Prudent dietary pattern; CESC cis rs2286503 0.780 rs929464 chr7:22874770 T/C cg13679077 chr7:22862647 TOMM7 0.59 7.55 0.42 7.17e-13 Fibrinogen; CESC cis rs11098499 0.865 rs11098513 chr4:120316075 A/G cg24375607 chr4:120327624 NA 0.46 5.59 0.32 5.52e-8 Corneal astigmatism; CESC cis rs10911232 0.507 rs4266836 chr1:183029070 T/G ch.1.3577855R chr1:183094577 LAMC1 0.86 13.28 0.63 3.52e-31 Hypertriglyceridemia; CESC cis rs6500395 0.928 rs4553627 chr16:48708801 A/T cg04672837 chr16:48644449 N4BP1 -0.52 -6.64 -0.38 1.75e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4803468 0.935 rs12602 chr19:41889748 T/C cg09537434 chr19:41945824 ATP5SL -1.07 -18.75 -0.76 1.72e-50 Height; CESC cis rs2066819 1.000 rs57279772 chr12:56698960 G/A cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs1005277 0.579 rs1780121 chr10:38529437 C/A cg00409905 chr10:38381863 ZNF37A -0.51 -6.77 -0.38 8.46e-11 Extrinsic epigenetic age acceleration; CESC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg18404041 chr3:52824283 ITIH1 -0.5 -8.26 -0.45 7.16e-15 Bipolar disorder; CESC cis rs8067545 0.586 rs2526478 chr17:20130452 A/G cg13482628 chr17:19912719 NA 0.43 5.65 0.33 4.18e-8 Schizophrenia; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16406212 chr2:24163862 UBXN2A 0.45 6.15 0.35 2.87e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg07308232 chr7:1071921 C7orf50 -0.45 -6.04 -0.35 5.3e-9 Longevity;Endometriosis; CESC cis rs9399135 0.935 rs6908681 chr6:135337733 A/G cg24558204 chr6:135376177 HBS1L 0.52 7.18 0.4 7.05e-12 Red blood cell count; CESC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg02475777 chr4:1388615 CRIPAK -0.56 -7.05 -0.4 1.53e-11 Longevity; CESC cis rs2731664 0.756 rs2545796 chr5:176864269 T/C cg23176889 chr5:176863531 GRK6 -0.64 -11.1 -0.56 9.37e-24 Intelligence (multi-trait analysis); CESC cis rs17253792 0.822 rs75509578 chr14:56133493 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.81 6.25 0.36 1.67e-9 Putamen volume; CESC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg26335602 chr6:28129616 ZNF389 0.53 6.89 0.39 4.07e-11 Depression; CESC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg26587870 chr6:27730563 NA -0.59 -5.24 -0.31 3.26e-7 Depression; CESC cis rs1185460 1.000 rs7127212 chr11:118953202 A/G cg23280166 chr11:118938394 VPS11 -0.5 -6.62 -0.38 1.95e-10 Coronary artery disease; CESC cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.42 6.89 0.39 3.96e-11 Personality dimensions; CESC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg18876405 chr7:65276391 NA 0.52 7.09 0.4 1.24e-11 Aortic root size; CESC cis rs8180040 0.726 rs13094672 chr3:47149439 C/T cg27129171 chr3:47204927 SETD2 0.7 10.5 0.54 8.74e-22 Colorectal cancer; CESC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg12463550 chr7:65579703 CRCP -0.45 -5.72 -0.33 2.86e-8 Aortic root size; CESC cis rs35123781 0.696 rs10067965 chr5:139071353 T/C cg10513866 chr5:139070639 NA 0.44 6.35 0.36 9.27e-10 Schizophrenia; CESC cis rs6582630 0.638 rs10880620 chr12:38517467 A/G cg26384229 chr12:38710491 ALG10B -0.44 -5.97 -0.34 7.7e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs748404 0.650 rs556851 chr15:43571219 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.6 7.99 0.44 4.21e-14 Lung cancer; CESC cis rs4604732 0.631 rs10754561 chr1:247622800 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.45 6.46 0.37 5e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.39e-20 Developmental language disorder (linguistic errors); CESC cis rs965469 0.779 rs2236103 chr20:3276821 A/G cg25506879 chr20:3388711 C20orf194 0.47 5.11 0.3 6.12e-7 IFN-related cytopenia; CESC trans rs1814175 0.645 rs847639 chr11:49919603 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -6.36 -0.36 8.98e-10 Height; CESC cis rs476633 0.708 rs28656781 chr15:41447440 C/G cg18705301 chr15:41695430 NDUFAF1 -0.61 -9.0 -0.48 4.54e-17 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg04546413 chr19:29218101 NA 0.56 7.91 0.44 6.84e-14 Methadone dose in opioid dependence; CESC cis rs1153858 1.000 rs2461701 chr15:45703391 G/A cg21132104 chr15:45694354 SPATA5L1 0.76 10.15 0.53 1.12e-20 Homoarginine levels; CESC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg15145296 chr3:125709740 NA -0.46 -5.19 -0.3 4.14e-7 Blood pressure (smoking interaction); CESC trans rs1547374 0.694 rs225349 chr21:43776890 C/T cg09521743 chr10:75415752 SYNPO2L 0.5 6.93 0.39 3.12e-11 Pancreatic cancer; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20552752 chr15:90895281 ZNF774 -0.45 -6.33 -0.36 1.03e-9 Height; CESC cis rs1707322 0.964 rs785509 chr1:46527300 G/A cg05343316 chr1:45956843 TESK2 -0.42 -5.05 -0.3 8.16e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4984778 0.750 rs7198064 chr16:1272472 C/T cg07748719 chr16:1272498 TPSG1 0.81 12.6 0.61 7.74e-29 Blood protein levels; CESC cis rs668210 0.739 rs543952 chr11:65744275 T/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.68 7.36 0.41 2.3e-12 Cerebrospinal fluid biomarker levels; CESC trans rs2270927 1.000 rs4546360 chr5:75577563 T/C cg13563193 chr19:33072644 PDCD5 0.76 6.27 0.36 1.45e-9 Mean corpuscular volume; CESC cis rs523522 0.962 rs2393590 chr12:120913900 G/A cg27279351 chr12:120934652 DYNLL1 0.67 8.73 0.47 2.89e-16 High light scatter reticulocyte count; CESC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg18032046 chr6:28092343 ZSCAN16 -0.57 -6.47 -0.37 4.74e-10 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00171578 chr1:147789747 NA -0.68 -8.67 -0.47 4.34e-16 Gut microbiome composition (summer); CESC cis rs12534701 1.000 rs12534701 chr7:154680910 A/C cg24255201 chr7:154684926 DPP6 -0.47 -6.56 -0.37 2.88e-10 Colorectal cancer (diet interaction); CESC cis rs12476592 0.602 rs262472 chr2:63833616 G/A cg17519650 chr2:63277830 OTX1 -0.45 -5.12 -0.3 5.75e-7 Childhood ear infection; CESC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg14393609 chr7:65229607 NA -0.5 -6.83 -0.39 5.81e-11 Aortic root size; CESC cis rs9457247 0.967 rs1794696 chr6:167396174 T/C cg23791538 chr6:167370224 RNASET2 -0.58 -8.22 -0.45 9.24e-15 Crohn's disease; CESC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg11965913 chr1:205819406 PM20D1 0.79 12.71 0.62 3.15e-29 Menarche (age at onset); CESC cis rs2425143 0.818 rs7272684 chr20:34424692 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.63 5.22 0.31 3.67e-7 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18073423 chr4:9514864 NA -0.5 -6.14 -0.35 3e-9 Gut microbiome composition (summer); CESC cis rs7772486 0.743 rs9403742 chr6:146060193 A/C cg05347473 chr6:146136440 FBXO30 0.5 6.57 0.37 2.73e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2635047 0.875 rs2635040 chr18:44640972 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.49 6.5 0.37 3.9e-10 Educational attainment; CESC cis rs11122272 0.735 rs2790886 chr1:231529491 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs9300255 0.602 rs1716177 chr12:123655457 C/T cg05973401 chr12:123451056 ABCB9 0.54 6.04 0.35 5.31e-9 Neutrophil percentage of white cells; CESC cis rs11209002 0.592 rs4655672 chr1:67553543 C/T cg02640540 chr1:67518911 SLC35D1 0.45 5.13 0.3 5.47e-7 Crohn's disease; CESC cis rs1546924 0.570 rs197412 chr1:112308953 T/C cg23955903 chr1:112298873 DDX20;C1orf183 0.43 5.55 0.32 6.88e-8 Body mass index; CESC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -5.81 -0.34 1.77e-8 Tonsillectomy; CESC cis rs1401999 1.000 rs6804242 chr3:183659463 A/T cg01324343 chr3:183735012 ABCC5 0.64 13.44 0.64 9.36e-32 Anterior chamber depth; CESC trans rs61931739 1.000 rs1852223 chr12:34013251 C/T cg26384229 chr12:38710491 ALG10B -0.45 -6.23 -0.36 1.87e-9 Morning vs. evening chronotype; CESC cis rs3796352 1.000 rs13092352 chr3:52969697 C/T cg12962167 chr3:53033115 SFMBT1 0.6 5.09 0.3 6.95e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs782590 0.764 rs2054728 chr2:55818419 C/T cg18811423 chr2:55921094 PNPT1 0.76 12.05 0.59 6.03e-27 Metabolic syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24103461 chr1:205091125 RBBP5 0.58 6.66 0.38 1.59e-10 Gut microbiome composition (summer); CESC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg12143784 chr7:64541923 NA 0.37 5.13 0.3 5.63e-7 Calcium levels; CESC cis rs752010 0.619 rs10789406 chr1:42105182 G/T cg06885757 chr1:42089581 HIVEP3 -0.48 -7.98 -0.44 4.53e-14 Lupus nephritis in systemic lupus erythematosus; CESC cis rs6496667 0.533 rs2074584 chr15:91009381 C/T cg22089800 chr15:90895588 ZNF774 0.44 5.63 0.33 4.61e-8 Rheumatoid arthritis; CESC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg18876405 chr7:65276391 NA -0.5 -6.83 -0.39 5.93e-11 Aortic root size; CESC cis rs7503807 1.000 rs12936076 chr17:78601195 C/T cg09596252 chr17:78655493 RPTOR 0.54 7.96 0.44 5.16e-14 Obesity; CESC cis rs2345546 1 rs2345546 chr16:25427472 C/T cg08360281 chr16:25269390 ZKSCAN2 1.05 10.13 0.53 1.33e-20 Major depression and alcohol dependence; CESC trans rs7615952 1.000 rs7616044 chr3:125649354 G/C cg07211511 chr3:129823064 LOC729375 -1.11 -15.63 -0.69 1.81e-39 Blood pressure (smoking interaction); CESC cis rs9287719 0.781 rs6714795 chr2:10759134 C/T cg02196655 chr2:10830764 NOL10 -0.36 -5.59 -0.32 5.58e-8 Prostate cancer; CESC cis rs1670533 1.000 rs6839931 chr4:1053172 A/G cg04106633 chr4:1044584 NA 0.41 5.32 0.31 2.25e-7 Recombination rate (females); CESC cis rs12586317 0.547 rs10130773 chr14:35445299 G/A cg16230307 chr14:35515116 FAM177A1 0.96 10.66 0.55 2.55e-22 Psoriasis; CESC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg10351095 chr21:47802916 PCNT -0.45 -6.22 -0.36 1.9e-9 Testicular germ cell tumor; CESC cis rs2274273 0.840 rs66486619 chr14:55869555 T/G cg04306507 chr14:55594613 LGALS3 0.27 5.3 0.31 2.44e-7 Protein biomarker; CESC cis rs6831352 0.918 rs17218073 chr4:100055739 G/A cg13256891 chr4:100009986 ADH5 -0.77 -8.45 -0.46 1.97e-15 Alcohol dependence; CESC cis rs861020 0.630 rs628300 chr1:209998298 C/T cg09163369 chr1:210001066 C1orf107 0.4 5.2 0.3 3.91e-7 Orofacial clefts; CESC cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg17211192 chr8:82754475 SNX16 0.52 6.64 0.38 1.73e-10 Diastolic blood pressure; CESC cis rs10744422 0.858 rs10773627 chr12:123311853 A/G cg25930673 chr12:123319894 HIP1R -0.65 -5.28 -0.31 2.72e-7 Schizophrenia; CESC cis rs2070433 0.756 rs9637220 chr21:47887436 T/C cg12379764 chr21:47803548 PCNT 0.52 6.31 0.36 1.18e-9 Lymphocyte counts; CESC cis rs7707921 0.671 rs2406911 chr5:81312256 A/G cg15871215 chr5:81402204 ATG10 0.38 5.49 0.32 9.54e-8 Breast cancer; CESC cis rs6429082 0.715 rs2291687 chr1:235594182 A/G cg26050004 chr1:235667680 B3GALNT2 -0.54 -6.91 -0.39 3.65e-11 Adiposity; CESC cis rs13223928 0.651 rs4722426 chr7:3150697 C/T cg19214707 chr7:3157722 NA 0.44 6.02 0.35 5.65e-9 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs3818285 0.679 rs2475275 chr10:111633979 C/T cg00817464 chr10:111662876 XPNPEP1 0.43 6.61 0.38 2.16e-10 Superior crus of antihelix expression; CESC cis rs5995756 0.761 rs6001637 chr22:40001083 A/G cg03390717 chr22:39966585 CACNA1I -0.35 -6.15 -0.35 2.79e-9 Autism spectrum disorder or schizophrenia; CESC cis rs7267979 0.866 rs2424699 chr20:25257462 G/A cg08601574 chr20:25228251 PYGB 0.38 5.35 0.31 1.9e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs9581857 0.685 rs9319369 chr13:28042323 A/T cg01674679 chr13:27998804 GTF3A -0.69 -5.53 -0.32 7.63e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs17761864 0.762 rs11658881 chr17:2072949 A/G cg16513277 chr17:2031491 SMG6 0.42 5.28 0.31 2.75e-7 Esophageal cancer (squamous cell); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12056857 chr12:100593408 ACTR6 0.55 6.54 0.37 3.13e-10 Gut microbiome composition (summer); CESC cis rs17433780 0.808 rs12122780 chr1:89508916 T/C cg09516651 chr1:89888402 LOC400759 0.7 10.7 0.55 1.94e-22 Carotid intima media thickness; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12970008 chr11:3186095 OSBPL5 0.43 6.07 0.35 4.41e-9 Systemic lupus erythematosus; CESC cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg07636037 chr3:49044803 WDR6 1.06 18.4 0.75 2.81e-49 Parkinson's disease; CESC cis rs2279817 0.865 rs35255680 chr1:17981184 A/C cg21791023 chr1:18019539 ARHGEF10L -0.55 -7.13 -0.4 9.39e-12 Neuroticism; CESC cis rs9302635 0.513 rs12444701 chr16:72155240 C/T cg16558253 chr16:72132732 DHX38 -0.46 -6.04 -0.35 5.09e-9 Blood protein levels; CESC cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg22431228 chr1:16359049 CLCNKA -0.49 -8.17 -0.45 1.27e-14 Dilated cardiomyopathy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21810621 chr11:1331345 LOC255512;TOLLIP -0.45 -6.33 -0.36 1.04e-9 Fibrinogen levels; CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 6.58 0.37 2.55e-10 Electroencephalogram traits; CESC cis rs2273669 0.667 rs10457187 chr6:109336051 G/A cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26567788 chr11:118401236 TMEM25;TTC36 -0.64 -7.5 -0.42 9.81e-13 Gut microbiome composition (summer); CESC cis rs9300255 0.537 rs2682429 chr12:123642955 C/G cg19016782 chr12:123741754 C12orf65 -0.4 -5.77 -0.33 2.27e-8 Neutrophil percentage of white cells; CESC trans rs1814175 0.669 rs11040473 chr11:49703813 C/T cg15704280 chr7:45808275 SEPT13 -0.83 -11.53 -0.58 3.31e-25 Height; CESC cis rs662064 0.925 rs597438 chr1:10554505 A/G cg20482658 chr1:10539492 PEX14 -0.4 -8.37 -0.46 3.4e-15 Asthma; CESC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg13770153 chr20:60521292 NA -0.46 -6.0 -0.35 6.55e-9 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09391093 chr10:38265555 ZNF25 -0.62 -6.9 -0.39 3.88e-11 Gut microbiome composition (summer); CESC trans rs6495367 1.000 rs3851677 chr15:79380869 C/T cg01071459 chr5:92939654 NA 0.38 6.13 0.35 3.25e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20715365 chr17:73900573 MRPL38 0.53 6.02 0.35 5.9e-9 Gut microbiome composition (summer); CESC cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg16262614 chr3:133464971 TF 0.4 7.83 0.43 1.18e-13 Iron status biomarkers (transferrin levels); CESC cis rs72781680 0.848 rs56371415 chr2:23932603 C/G cg08917208 chr2:24149416 ATAD2B 1.09 10.09 0.53 1.85e-20 Lymphocyte counts; CESC cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.65 -0.55 2.75e-22 Chronic sinus infection; CESC cis rs2072732 0.861 rs6692292 chr1:2959610 C/T cg03976712 chr1:2946727 NA -0.31 -5.25 -0.31 3.13e-7 Plateletcrit; CESC cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg20503657 chr10:835505 NA 0.84 8.61 0.47 6.52e-16 Eosinophil percentage of granulocytes; CESC cis rs7953249 0.656 rs2178463 chr12:121389721 A/G cg25281562 chr12:121454272 C12orf43 -0.46 -5.78 -0.33 2.12e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg03709012 chr19:19516395 GATAD2A -0.95 -13.78 -0.65 6.29e-33 Tonsillectomy; CESC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.24 -0.36 1.68e-9 Menopause (age at onset); CESC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.34 0.5 3.98e-18 Menopause (age at onset); CESC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.13 -0.3 5.56e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11942548 chr13:22248814 FGF9 -0.57 -6.19 -0.36 2.31e-9 Gut microbiome composition (summer); CESC cis rs6831352 0.918 rs29001231 chr4:100046680 T/C cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs6460942 0.908 rs77799203 chr7:12264432 C/G cg06484146 chr7:12443880 VWDE -0.58 -6.08 -0.35 4.22e-9 Coronary artery disease; CESC cis rs7772486 0.846 rs2892453 chr6:146377717 C/A cg05347473 chr6:146136440 FBXO30 0.49 6.67 0.38 1.51e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs11696501 0.739 rs6073822 chr20:44251880 A/G cg11783356 chr20:44313418 WFDC10B -0.35 -5.42 -0.32 1.35e-7 Brain structure; CESC cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg20848291 chr7:100343083 ZAN -0.66 -7.08 -0.4 1.31e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs1814175 0.765 rs1794141 chr11:49914135 G/C cg15704280 chr7:45808275 SEPT13 -1.03 -21.21 -0.79 4.77e-59 Height; CESC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg05863683 chr7:1912471 MAD1L1 0.44 6.62 0.38 1.95e-10 Bipolar disorder and schizophrenia; CESC cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg00074818 chr8:8560427 CLDN23 0.38 5.46 0.32 1.1e-7 Obesity-related traits; CESC cis rs4900538 0.927 rs8005804 chr14:102957803 A/G cg18135206 chr14:102964638 TECPR2 0.84 11.44 0.58 6.53e-25 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.09 -0.3 6.72e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08861270 chr19:3700656 PIP5K1C -0.65 -7.92 -0.44 6.39e-14 Gut microbiome composition (summer); CESC cis rs11098499 0.535 rs7671759 chr4:120248094 A/C cg09307838 chr4:120376055 NA 0.76 9.93 0.52 5.9e-20 Corneal astigmatism; CESC cis rs854765 0.893 rs712265 chr17:18008447 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.44 -5.74 -0.33 2.6e-8 Total body bone mineral density; CESC cis rs9649465 0.935 rs1605285 chr7:123374412 A/G cg04330084 chr7:123175371 IQUB -0.38 -5.13 -0.3 5.72e-7 Migraine; CESC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg24531977 chr5:56204891 C5orf35 -0.87 -10.68 -0.55 2.24e-22 Initial pursuit acceleration; CESC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Parkinson's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10387458 chr1:93645817 TMED5;CCDC18 -0.43 -6.22 -0.36 1.88e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9911578 1.000 rs12453459 chr17:56624291 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC cis rs7586879 0.575 rs6712981 chr2:25126230 A/G cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.02e-11 Body mass index; CESC cis rs6032067 0.929 rs6032063 chr20:43854475 C/T cg10761708 chr20:43804764 PI3 0.5 6.15 0.35 2.83e-9 Blood protein levels; CESC cis rs11055008 0.935 rs10845601 chr12:12820134 A/G cg09462578 chr12:12878428 APOLD1 0.63 8.08 0.44 2.33e-14 Pulse pressure; CESC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg23161317 chr6:28129485 ZNF389 0.47 5.88 0.34 1.21e-8 Depression; CESC cis rs2228479 0.717 rs1007932 chr16:89838541 C/T cg00800038 chr16:89945340 TCF25 -0.78 -7.56 -0.42 6.7e-13 Skin colour saturation; CESC cis rs7259376 0.775 rs7257134 chr19:22540857 A/T cg02657401 chr19:22469223 NA -0.28 -5.5 -0.32 9.08e-8 Menopause (age at onset); CESC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg11663144 chr21:46675770 NA -0.62 -9.86 -0.52 9.62e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs561341 1.000 rs55962687 chr17:30260369 C/T cg12193833 chr17:30244370 NA -0.67 -6.13 -0.35 3.14e-9 Hip circumference adjusted for BMI; CESC cis rs631288 0.557 rs4534444 chr1:146679283 T/C cg25205988 chr1:146714368 CHD1L 1.02 6.44 0.37 5.5e-10 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg11301795 chr4:187892539 NA -0.75 -12.18 -0.6 2.18e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg08781755 chr2:44172074 LRPPRC 0.4 6.3 0.36 1.25e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6502050 0.799 rs58538819 chr17:80107153 G/C cg11859384 chr17:80120422 CCDC57 -0.4 -5.44 -0.32 1.22e-7 Life satisfaction; CESC cis rs1881744 1.000 rs55647411 chr12:47815942 T/G cg18786123 chr12:47787067 NA 0.67 5.07 0.3 7.66e-7 Metabolite levels (HVA/5-HIAA ratio); CESC cis rs514406 0.893 rs1242315 chr1:53417181 A/G cg25767906 chr1:53392781 SCP2 -0.43 -5.37 -0.31 1.75e-7 Monocyte count; CESC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg27057461 chr7:158136379 PTPRN2 -0.34 -5.26 -0.31 2.91e-7 Calcium levels; CESC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg08859206 chr1:53392774 SCP2 0.6 8.96 0.48 5.76e-17 Monocyte count; CESC cis rs208520 0.779 rs208446 chr6:66903515 T/C cg07460842 chr6:66804631 NA -0.86 -10.11 -0.53 1.55e-20 Exhaled nitric oxide output; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg22145576 chr8:144897413 SCRIB -0.45 -5.99 -0.35 6.67e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7692995 1.000 rs7663887 chr4:17902920 G/T cg08925142 chr4:18023851 LCORL -0.46 -5.28 -0.31 2.75e-7 Height; CESC trans rs34117943 1 rs34117943 chr16:68819642 C/CT cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -8.51 -0.46 1.27e-15 Mean corpuscular volume; CESC cis rs11723261 0.621 rs6599307 chr4:143777 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.46 6.14 0.35 2.98e-9 Immune response to smallpox vaccine (IL-6); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04100724 chr12:92539208 BTG1 0.46 6.21 0.36 2.06e-9 Systemic lupus erythematosus; CESC cis rs72945132 0.882 rs1061328 chr11:70185325 C/T cg14191688 chr11:70257035 CTTN 0.43 5.51 0.32 8.64e-8 Coronary artery disease; CESC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.5 -6.23 -0.36 1.78e-9 Tonsillectomy; CESC cis rs711830 0.965 rs2857532 chr2:177033283 A/G cg13092806 chr2:177043255 NA 0.87 11.85 0.59 2.73e-26 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CESC cis rs6831352 0.819 rs13832 chr4:99993075 C/A cg21548116 chr4:100009993 ADH5 0.5 5.49 0.32 9.3e-8 Alcohol dependence; CESC trans rs1814175 0.616 rs1722001 chr11:49894427 A/G cg15704280 chr7:45808275 SEPT13 -1.0 -18.78 -0.76 1.35e-50 Height; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09391705 chr13:26828746 CDK8 0.46 6.16 0.35 2.63e-9 Systemic lupus erythematosus; CESC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg07677032 chr17:61819896 STRADA 0.42 5.36 0.31 1.78e-7 Height; CESC cis rs3087591 0.960 rs9898664 chr17:29567152 T/C cg24425628 chr17:29625626 OMG;NF1 -0.42 -5.25 -0.31 3.12e-7 Hip circumference; CESC cis rs9828933 0.938 rs9809432 chr3:64002953 G/A cg16258503 chr3:63850278 ATXN7;THOC7 -0.61 -6.18 -0.35 2.43e-9 Type 2 diabetes; CESC cis rs1499972 0.590 rs1456196 chr3:117654553 C/A cg07612923 chr3:117604196 NA 0.69 6.3 0.36 1.22e-9 Schizophrenia; CESC cis rs2120019 0.935 rs8042409 chr15:75350433 G/A cg09165964 chr15:75287851 SCAMP5 -0.73 -8.56 -0.47 9.11e-16 Blood trace element (Zn levels); CESC cis rs2274273 1.000 rs10149435 chr14:55627489 C/T cg04306507 chr14:55594613 LGALS3 0.28 5.28 0.31 2.71e-7 Protein biomarker; CESC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg00166722 chr3:10149974 C3orf24 0.46 5.78 0.33 2.08e-8 Alzheimer's disease; CESC cis rs748404 0.631 rs7163288 chr15:43671355 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.64 8.25 0.45 7.36e-15 Lung cancer; CESC cis rs3806843 1.000 rs6898906 chr5:140169299 C/G cg26395211 chr5:140044315 WDR55 -0.42 -5.43 -0.32 1.26e-7 Depressive symptoms (multi-trait analysis); CESC cis rs854765 0.552 rs11078407 chr17:17841083 T/C cg09796270 chr17:17721594 SREBF1 0.41 5.79 0.34 2e-8 Total body bone mineral density; CESC cis rs868036 0.609 rs2045960 chr15:68092079 G/A cg08079166 chr15:68083412 MAP2K5 0.38 5.41 0.32 1.42e-7 Restless legs syndrome; CESC trans rs17248895 0.803 rs8004267 chr14:67883129 A/G cg05725531 chr6:46097441 ENPP4 0.51 6.04 0.35 5.26e-9 Immature fraction of reticulocytes;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs28374715 0.578 rs17730589 chr15:41600878 T/C cg02330683 chr15:41787940 ITPKA 0.48 5.54 0.32 7.36e-8 Ulcerative colitis; CESC cis rs9814567 0.929 rs1534027 chr3:134284662 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.46 -6.12 -0.35 3.4e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2594989 0.887 rs2454498 chr3:11500953 A/G cg00170343 chr3:11313890 ATG7 0.56 5.1 0.3 6.55e-7 Circulating chemerin levels; CESC cis rs9359856 0.510 rs2748298 chr6:90436877 A/C cg13799429 chr6:90582589 CASP8AP2 -0.68 -7.65 -0.43 3.72e-13 Bipolar disorder; CESC cis rs3008870 0.755 rs2755271 chr1:67474977 C/T cg02640540 chr1:67518911 SLC35D1 0.45 5.51 0.32 8.51e-8 Lymphocyte percentage of white cells; CESC cis rs80282103 0.618 rs11818314 chr10:1148157 G/C cg08668510 chr10:1095578 IDI1 0.77 6.35 0.36 9.51e-10 Glomerular filtration rate (creatinine); CESC trans rs9650657 0.644 rs4395858 chr8:10521021 C/T cg15556689 chr8:8085844 FLJ10661 0.5 6.28 0.36 1.38e-9 Neuroticism; CESC cis rs820218 0.743 rs4789223 chr17:73641899 G/A cg01592526 chr17:73663357 RECQL5;SAP30BP -0.39 -5.25 -0.31 3.05e-7 Rotator cuff tears; CESC cis rs7647973 0.600 rs35174559 chr3:49287759 T/C cg02487422 chr3:49467188 NICN1 0.38 5.24 0.31 3.24e-7 Menarche (age at onset); CESC cis rs6570726 0.935 rs409725 chr6:145840340 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.74 0.38 1e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1670533 1.000 rs6812596 chr4:1069866 A/G cg27284194 chr4:1044797 NA 0.45 5.73 0.33 2.78e-8 Recombination rate (females); CESC trans rs208520 0.545 rs6899712 chr6:66749670 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 18.48 0.75 1.53e-49 Exhaled nitric oxide output; CESC cis rs9354308 0.899 rs1938059 chr6:66539291 G/A cg07460842 chr6:66804631 NA 0.58 6.59 0.38 2.37e-10 Metabolite levels; CESC cis rs763121 0.819 rs5757133 chr22:38947835 A/G cg06544989 chr22:39130855 UNC84B -0.46 -7.78 -0.43 1.58e-13 Menopause (age at onset); CESC cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg16339924 chr4:17578868 LAP3 0.6 7.47 0.42 1.16e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg09699651 chr6:150184138 LRP11 0.41 5.13 0.3 5.51e-7 Lung cancer; CESC cis rs1348850 0.632 rs10167783 chr2:178519041 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.55 0.42 6.83e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1707322 1.000 rs7547189 chr1:46319514 C/A cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2569991 0.588 rs2596909 chr3:12928672 G/C cg22481960 chr3:13008800 IQSEC1 -0.56 -6.71 -0.38 1.17e-10 Periodontitis (DPAL); CESC cis rs77956314 0.515 rs9804817 chr12:117440220 G/A cg02017074 chr12:117425053 FBXW8 -0.79 -8.42 -0.46 2.34e-15 Subcortical brain region volumes;Hippocampal volume; CESC cis rs3747547 0.584 rs1887879 chr9:38079565 G/C cg13774184 chr9:37916125 SHB -0.64 -5.49 -0.32 9.57e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg24920358 chr1:40204285 PPIE 0.4 5.84 0.34 1.52e-8 Blood protein levels; CESC cis rs17039065 0.920 rs73838438 chr4:109451248 G/T cg16022748 chr4:109541635 LOC285456;RPL34 0.62 5.61 0.33 5.08e-8 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.38 0.31 1.6e-7 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00340921 chr19:7600526 PNPLA6 0.6 6.76 0.38 8.87e-11 Gut microbiome composition (summer); CESC cis rs7267979 1.000 rs2387880 chr20:25377787 T/C cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.92e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9660992 0.710 rs1668872 chr1:205236069 G/A cg00857998 chr1:205179979 DSTYK 0.47 5.35 0.31 1.87e-7 Mean corpuscular volume;Mean platelet volume; CESC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs2415984 0.622 rs2817568 chr14:46940986 C/G cg14871534 chr14:47121158 RPL10L 0.38 5.93 0.34 9.18e-9 Number of children ever born; CESC cis rs6460942 0.749 rs79221452 chr7:12202897 T/C cg06484146 chr7:12443880 VWDE -0.58 -5.55 -0.32 7.03e-8 Coronary artery disease; CESC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg22800045 chr5:56110881 MAP3K1 0.45 5.53 0.32 7.57e-8 Coronary artery disease; CESC cis rs11252926 0.528 rs11252090 chr10:436547 C/T cg03684893 chr10:554711 DIP2C 0.35 5.19 0.3 4.14e-7 Psychosis in Alzheimer's disease; CESC cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg17366294 chr4:99064904 C4orf37 0.59 8.45 0.46 1.94e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.13e-10 Bipolar disorder; CESC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.22 0.31 3.59e-7 Bipolar disorder; CESC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg26939375 chr7:64535504 NA 0.76 10.89 0.56 4.67e-23 Aortic root size; CESC trans rs11098499 0.909 rs78332141 chr4:120375782 C/T cg25214090 chr10:38739885 LOC399744 0.69 9.59 0.51 6.76e-19 Corneal astigmatism; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg03846288 chr15:59279849 RNF111 -0.46 -6.09 -0.35 3.89e-9 Height; CESC cis rs10924309 0.765 rs1122735 chr1:245853299 G/A cg00036263 chr1:245852353 KIF26B -0.49 -6.12 -0.35 3.33e-9 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs9487051 0.621 rs351726 chr6:109548304 C/T cg01475377 chr6:109611718 NA -0.38 -5.18 -0.3 4.49e-7 Reticulocyte fraction of red cells; CESC cis rs2777491 0.574 rs11635906 chr15:41779260 A/G cg20272979 chr15:41787780 ITPKA 0.44 5.24 0.31 3.22e-7 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07666984 chr4:153858209 NA -0.54 -6.08 -0.35 4.22e-9 Gut microbiome composition (summer); CESC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg26441486 chr22:50317300 CRELD2 0.41 5.22 0.31 3.7e-7 Schizophrenia; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11750080 chr17:74379913 SPHK1 -0.53 -6.71 -0.38 1.2e-10 Asthma; CESC cis rs6693567 0.586 rs12031973 chr1:150485566 T/G cg09579323 chr1:150459698 TARS2 0.47 5.75 0.33 2.47e-8 Migraine; CESC trans rs9354352 0.967 rs9354351 chr6:66696271 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 9.93 0.52 5.77e-20 Initial pursuit acceleration in psychotic disorders; CESC cis rs6831352 0.918 rs29001214 chr4:100051733 A/G cg13256891 chr4:100009986 ADH5 -0.77 -8.43 -0.46 2.27e-15 Alcohol dependence; CESC cis rs959260 1.000 rs4789188 chr17:73397871 A/C cg12999837 chr17:73267436 MIF4GD -0.45 -5.21 -0.3 3.8e-7 Systemic lupus erythematosus; CESC cis rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01152906 chr10:7861152 TAF3 0.48 6.07 0.35 4.34e-9 Gut microbiota (bacterial taxa); CESC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.09 -0.35 3.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10504073 0.669 rs818558 chr8:50030855 A/G cg00325661 chr8:49890786 NA 0.51 7.52 0.42 8.73e-13 Blood metabolite ratios; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12849807 chr6:90348187 LYRM2 0.57 6.81 0.39 6.54e-11 Gut microbiome composition (summer); CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg11965913 chr1:205819406 PM20D1 0.91 16.7 0.72 2.84e-43 Menarche (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg04135372 chr2:99061383 INPP4A -0.47 -6.21 -0.36 2.02e-9 Ulcerative colitis; CESC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg08736216 chr1:53307985 ZYG11A -0.39 -6.13 -0.35 3.13e-9 Monocyte count; CESC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg06221963 chr1:154839813 KCNN3 0.48 7.47 0.42 1.15e-12 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13357178 chr17:41623362 ETV4 0.54 6.21 0.36 2.01e-9 Gut microbiome composition (summer); CESC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs12148488 0.763 rs2304902 chr15:75340727 G/T cg17294928 chr15:75287854 SCAMP5 0.56 7.03 0.4 1.74e-11 Caffeine consumption; CESC cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72634258 0.554 rs1012477 chr1:7858135 C/G cg26816564 chr1:7831052 VAMP3 -0.59 -5.7 -0.33 3.14e-8 Inflammatory bowel disease; CESC cis rs3820068 0.581 rs1122386 chr1:15946877 C/T cg17385448 chr1:15911702 AGMAT 0.42 6.83 0.39 5.64e-11 Systolic blood pressure; CESC cis rs4785763 0.570 rs4785759 chr16:90050880 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.53 -6.93 -0.39 3.22e-11 Melanoma; CESC cis rs2180341 0.960 rs1543432 chr6:127698018 T/C cg27446573 chr6:127587934 RNF146 1.05 15.29 0.68 2.96e-38 Breast cancer; CESC cis rs6977660 0.652 rs10486362 chr7:19755224 A/G cg05791153 chr7:19748676 TWISTNB -0.83 -7.3 -0.41 3.39e-12 Thyroid stimulating hormone; CESC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.19 -0.4 6.72e-12 Total body bone mineral density; CESC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg21724239 chr8:58056113 NA 0.57 5.86 0.34 1.39e-8 Developmental language disorder (linguistic errors); CESC cis rs7714584 1.000 rs4958424 chr5:150225036 C/T cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.68e-7 Life satisfaction; CESC cis rs6541297 0.703 rs677990 chr1:230320428 G/A cg20703242 chr1:230279135 GALNT2 -0.41 -5.35 -0.31 1.94e-7 Coronary artery disease; CESC trans rs1814175 0.645 rs10839448 chr11:49938930 G/A cg15704280 chr7:45808275 SEPT13 -0.98 -18.48 -0.75 1.48e-49 Height; CESC cis rs10479542 0.503 rs12719865 chr5:178993566 C/T cg19626725 chr5:178986131 RUFY1 0.35 5.45 0.32 1.17e-7 Lung cancer; CESC cis rs787274 1.000 rs2796037 chr9:115511826 C/T cg13803584 chr9:115635662 SNX30 0.52 5.44 0.32 1.21e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs8062405 1.000 rs7198606 chr16:28875122 T/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs938554 0.784 rs4481233 chr4:9956079 A/G cg11266682 chr4:10021025 SLC2A9 0.42 5.19 0.3 4.28e-7 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06138422 chr12:133338013 ANKLE2 0.55 6.47 0.37 4.63e-10 Gut microbiome composition (summer); CESC cis rs7216064 1.000 rs56393562 chr17:65933918 C/T cg07042672 chr17:66097459 LOC651250 -0.54 -5.87 -0.34 1.3e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs921968 0.541 rs585185 chr2:219457741 G/A cg02176678 chr2:219576539 TTLL4 0.48 8.27 0.45 6.46e-15 Mean corpuscular hemoglobin concentration; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10887309 chr12:49412603 PRKAG1 -0.39 -6.0 -0.35 6.56e-9 Gambling; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04190776 chr16:89614921 SPG7 0.51 6.95 0.39 2.89e-11 Fibrinogen levels; CESC cis rs7267979 1.000 rs6076345 chr20:25381895 T/G cg08601574 chr20:25228251 PYGB -0.38 -5.45 -0.32 1.13e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2072499 0.966 rs11587860 chr1:156156951 G/C cg24450063 chr1:156163899 SLC25A44 1.08 21.39 0.8 1.2e-59 Testicular germ cell tumor; CESC cis rs7208859 0.673 rs73265633 chr17:29236306 G/T cg19761014 chr17:28927070 LRRC37B2 0.71 5.63 0.33 4.48e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7212590 0.529 rs60283440 chr17:57994248 T/C cg20303301 chr17:57937339 TUBD1 -0.56 -5.55 -0.32 6.81e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CESC cis rs8070740 0.838 rs57745425 chr17:5327528 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.52 5.7 0.33 3.23e-8 Menopause (age at onset); CESC cis rs4243830 0.850 rs4908904 chr1:6580250 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.76 8.63 0.47 5.93e-16 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16339435 chr6:146285414 SHPRH 0.54 6.31 0.36 1.18e-9 Gut microbiome composition (summer); CESC cis rs2235642 0.750 rs1894649 chr16:1657284 C/G cg03715980 chr16:1756201 MAPK8IP3 0.39 5.25 0.31 3.18e-7 Coronary artery disease; CESC trans rs9929218 0.551 rs1886697 chr16:68716179 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.97 16.93 0.72 4.4e-44 Colorectal cancer; CESC cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -5.39 -0.31 1.59e-7 Breast cancer; CESC trans rs78049276 0.736 rs10305838 chr4:148400256 T/C cg13149281 chr14:23389818 RBM23;PRMT5 -0.69 -7.55 -0.42 6.94e-13 Pulse pressure; CESC cis rs459571 0.959 rs2810491 chr9:136923331 C/T cg13789015 chr9:136890014 NCRNA00094 -0.53 -7.34 -0.41 2.67e-12 Platelet distribution width; CESC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg22764044 chr5:178986830 RUFY1 0.49 7.24 0.41 4.85e-12 Lung cancer; CESC trans rs7906315 0.967 rs3814573 chr10:114898093 C/T cg07415687 chr6:7910841 TXNDC5 0.51 6.06 0.35 4.78e-9 Breast cancer; CESC cis rs6598955 0.724 rs12726972 chr1:26639634 A/G cg04990556 chr1:26633338 UBXN11 0.64 8.9 0.48 8.75e-17 Obesity-related traits; CESC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.35 -5.16 -0.3 4.82e-7 Personality dimensions; CESC cis rs2404602 0.692 rs67010831 chr15:76965308 T/G cg22467129 chr15:76604101 ETFA -0.34 -5.08 -0.3 7.27e-7 Blood metabolite levels; CESC cis rs11640533 0.901 rs11862250 chr16:53415038 C/A cg10144400 chr16:53407678 NA 0.42 5.44 0.32 1.22e-7 Intelligence (multi-trait analysis); CESC cis rs12477438 0.834 rs10179043 chr2:99687490 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.73 -0.55 1.54e-22 Chronic sinus infection; CESC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg11905131 chr22:24372483 LOC391322 -0.7 -10.05 -0.53 2.39e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg22535103 chr8:58192502 C8orf71 -0.65 -6.98 -0.39 2.38e-11 Developmental language disorder (linguistic errors); CESC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg25036284 chr2:26402008 FAM59B 0.86 9.36 0.5 3.44e-18 Gut microbiome composition (summer); CESC cis rs9611565 0.512 rs139573 chr22:42214785 G/A cg06634786 chr22:41940651 POLR3H -0.66 -6.51 -0.37 3.7e-10 Vitiligo; CESC cis rs2404602 0.598 rs11634019 chr15:76634680 A/G cg00316803 chr15:76480434 C15orf27 0.49 6.73 0.38 1.03e-10 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09925987 chr7:2629300 IQCE -0.6 -7.01 -0.4 2.01e-11 Gut microbiome composition (summer); CESC cis rs10823500 0.748 rs12355080 chr10:71963608 G/A cg04118878 chr10:71993077 PPA1 0.47 5.54 0.32 7.27e-8 Blood protein levels; CESC cis rs1005277 0.522 rs200943 chr10:38148730 A/G cg00409905 chr10:38381863 ZNF37A -0.56 -7.73 -0.43 2.23e-13 Extrinsic epigenetic age acceleration; CESC cis rs4819052 0.788 rs9978857 chr21:46705155 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 11.97 0.59 1.07e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11098499 0.954 rs4345162 chr4:120312959 G/A cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs453301 0.598 rs2921383 chr8:8892221 C/T cg15556689 chr8:8085844 FLJ10661 0.49 6.09 0.35 3.86e-9 Joint mobility (Beighton score); CESC cis rs7980687 0.638 rs7299943 chr12:123593485 A/T cg05973401 chr12:123451056 ABCB9 0.56 6.14 0.35 3.05e-9 Height;Educational attainment;Head circumference (infant); CESC cis rs9399137 0.507 rs4895437 chr6:135317354 G/A cg22676075 chr6:135203613 NA 0.53 7.09 0.4 1.22e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs644799 1.000 rs557079 chr11:95530125 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.94 0.48 6.65e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11785693 0.865 rs11784227 chr8:4970485 A/C cg26367366 chr8:4980734 NA 0.81 7.25 0.41 4.53e-12 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg08917208 chr2:24149416 ATAD2B 0.67 6.42 0.37 6.2e-10 Lymphocyte counts; CESC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg12311346 chr5:56204834 C5orf35 0.64 8.66 0.47 4.55e-16 Initial pursuit acceleration; CESC cis rs7071206 0.947 rs11002226 chr10:79399656 T/A cg07817648 chr10:79422355 NA -0.89 -11.2 -0.57 4.27e-24 Bone mineral density; CESC cis rs6500395 0.928 rs723807 chr16:48691443 A/G cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs8072100 0.840 rs9912311 chr17:45547132 T/C cg25173405 chr17:45401733 C17orf57 -0.43 -5.77 -0.33 2.25e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1801251 0.778 rs809639 chr2:233731244 C/G cg08000102 chr2:233561755 GIGYF2 0.6 8.01 0.44 3.62e-14 Coronary artery disease; CESC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.78 0.33 2.11e-8 Bipolar disorder; CESC cis rs367943 0.698 rs4336355 chr5:113000368 C/T cg12552261 chr5:112820674 MCC 0.46 5.88 0.34 1.26e-8 Type 2 diabetes; CESC cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1728785 0.901 rs1645974 chr16:68564774 C/G cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs12145833 0.596 rs12123491 chr1:243297924 C/G cg02356786 chr1:243265016 LOC731275 0.76 6.38 0.36 8.08e-10 Obesity (early onset extreme); CESC cis rs3749237 0.595 rs885592 chr3:49497883 T/G cg02487422 chr3:49467188 NICN1 0.56 8.19 0.45 1.11e-14 Resting heart rate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01267274 chr14:90864532 CALM1 0.56 6.1 0.35 3.7e-9 Gut microbiome composition (summer); CESC cis rs3806843 1.000 rs10223116 chr5:140192643 C/T cg26395211 chr5:140044315 WDR55 -0.39 -5.1 -0.3 6.52e-7 Depressive symptoms (multi-trait analysis); CESC trans rs877282 0.945 rs71489301 chr10:770191 A/G cg22713356 chr15:30763199 NA 1.14 11.22 0.57 3.6e-24 Uric acid levels; CESC cis rs6032067 0.929 rs2267864 chr20:43805279 C/G cg11264863 chr20:43835661 SEMG1 0.44 5.06 0.3 7.82e-7 Blood protein levels; CESC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg05025164 chr4:1340916 KIAA1530 0.6 8.3 0.45 5.4e-15 Longevity; CESC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg07092213 chr7:1199455 ZFAND2A -0.45 -5.2 -0.3 3.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs28498503 0.573 rs9955010 chr18:76654038 G/A cg00806245 chr18:76673096 NA -0.69 -5.66 -0.33 3.92e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs1044826 0.692 rs176987 chr3:139233001 G/A cg00490450 chr3:139108681 COPB2 -0.44 -5.45 -0.32 1.13e-7 Obesity-related traits; CESC cis rs8060686 0.920 rs55661503 chr16:67836552 T/A cg26727032 chr16:67993705 SLC12A4 -0.58 -6.26 -0.36 1.51e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs9549367 0.789 rs2025247 chr13:113882564 C/G cg18105134 chr13:113819100 PROZ -0.63 -7.55 -0.42 6.88e-13 Platelet distribution width; CESC cis rs1018836 0.628 rs6471085 chr8:91463783 G/A cg16814680 chr8:91681699 NA -0.55 -7.24 -0.41 4.86e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg11890956 chr21:40555474 PSMG1 -0.94 -14.76 -0.67 2.14e-36 Cognitive function; CESC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg25767906 chr1:53392781 SCP2 -0.57 -8.09 -0.44 2.23e-14 Monocyte count; CESC cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg10523679 chr1:76189770 ACADM 0.75 10.09 0.53 1.8e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs12142240 0.698 rs17357759 chr1:46832534 A/G cg10495392 chr1:46806563 NSUN4 0.55 6.1 0.35 3.84e-9 Menopause (age at onset); CESC cis rs9549260 0.755 rs17061491 chr13:41228210 T/A cg21288729 chr13:41239152 FOXO1 0.65 8.53 0.46 1.16e-15 Red blood cell count; CESC cis rs4728142 0.738 rs3807306 chr7:128580680 A/C cg06630958 chr7:128577819 IRF5 0.34 5.38 0.31 1.64e-7 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CESC cis rs9611565 0.512 rs5758439 chr22:42131762 C/T cg17376030 chr22:41985996 PMM1 -0.78 -8.33 -0.46 4.43e-15 Vitiligo; CESC cis rs637571 0.522 rs550435 chr11:65732651 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.65 0.38 1.71e-10 Eosinophil percentage of white cells; CESC trans rs6600671 1.000 rs2319969 chr1:121207335 A/G cg17023122 chr1:144479586 NA 0.48 6.57 0.37 2.58e-10 Hip geometry; CESC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg17178900 chr1:205818956 PM20D1 -0.69 -9.46 -0.5 1.75e-18 Menarche (age at onset); CESC cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg19717773 chr7:2847554 GNA12 -0.59 -9.06 -0.49 3.02e-17 Height; CESC cis rs7512552 0.839 rs1260405 chr1:150304781 A/G cg15654264 chr1:150340011 RPRD2 0.39 5.23 0.31 3.42e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs67478160 0.608 rs34066659 chr14:104263427 A/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.09 -0.4 1.2e-11 Schizophrenia; CESC cis rs1413885 0.516 rs6588138 chr1:65838366 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.46 5.98 0.34 7.15e-9 Anticoagulant levels; CESC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg23034840 chr1:205782522 SLC41A1 0.65 7.99 0.44 4.13e-14 Menarche (age at onset); CESC cis rs10465746 0.935 rs2389647 chr1:84403041 C/T cg10977910 chr1:84465055 TTLL7 0.47 6.21 0.36 2.09e-9 Obesity-related traits; CESC cis rs7772486 0.875 rs9322045 chr6:146384950 C/G cg23711669 chr6:146136114 FBXO30 0.85 12.56 0.61 1.08e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs67460515 0.563 rs73023235 chr3:160864123 G/A cg03342759 chr3:160939853 NMD3 -0.52 -6.51 -0.37 3.68e-10 Parkinson's disease; CESC cis rs36051895 0.623 rs62541543 chr9:5042082 G/A cg02405213 chr9:5042618 JAK2 -0.48 -5.64 -0.33 4.29e-8 Pediatric autoimmune diseases; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg05393424 chr1:91403111 ZNF644 0.4 6.3 0.36 1.21e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7818382 1.000 rs7818382 chr8:96054000 C/T cg09323728 chr8:95962352 TP53INP1 -0.33 -7.02 -0.4 1.83e-11 Alzheimer's disease (late onset); CESC cis rs2204008 0.580 rs11520047 chr12:38051778 T/A cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs9399137 0.507 rs6904897 chr6:135382980 T/G cg22676075 chr6:135203613 NA 0.52 6.85 0.39 5.13e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs561341 0.941 rs17780080 chr17:30343146 G/A cg27661571 chr11:113659931 NA -0.85 -7.51 -0.42 9.26e-13 Hip circumference adjusted for BMI; CESC cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg20573242 chr4:122745356 CCNA2 0.65 8.05 0.44 2.81e-14 Type 2 diabetes; CESC cis rs10905065 0.829 rs2246399 chr10:5799286 T/A cg11519256 chr10:5708881 ASB13 -0.39 -5.11 -0.3 6.23e-7 Menopause (age at onset); CESC cis rs1801251 1.000 rs283477 chr2:233649427 A/G cg25237894 chr2:233734115 C2orf82 0.47 7.93 0.44 6.29e-14 Coronary artery disease; CESC cis rs6831352 0.879 rs29001196 chr4:100054116 C/T cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs7917772 0.636 rs1475644 chr10:104491164 G/A cg04362960 chr10:104952993 NT5C2 -0.5 -5.79 -0.34 2e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs1953600 0.870 rs12770550 chr10:81953451 G/T cg04850286 chr10:81895943 PLAC9 0.29 5.06 0.3 7.95e-7 Sarcoidosis; CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg23281280 chr6:28129359 ZNF389 0.61 8.7 0.47 3.53e-16 Depression; CESC cis rs6580649 0.824 rs1635534 chr12:48386553 A/G cg05342945 chr12:48394962 COL2A1 -0.51 -6.1 -0.35 3.71e-9 Lung cancer; CESC cis rs11792861 0.926 rs72607174 chr9:111899132 A/T cg05043794 chr9:111880884 C9orf5 -0.42 -6.94 -0.39 3.04e-11 Menarche (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00252332 chr13:73633178 KLF5 -0.4 -6.14 -0.35 3.07e-9 Gambling; CESC cis rs8005677 1.000 rs1951119 chr14:23388326 A/C cg25600027 chr14:23388339 RBM23 -0.43 -5.32 -0.31 2.25e-7 Cognitive ability (multi-trait analysis); CESC cis rs9790314 1.000 rs163328 chr3:161073599 A/G cg03342759 chr3:160939853 NMD3 -0.47 -6.15 -0.35 2.79e-9 Morning vs. evening chronotype; CESC cis rs13064411 0.696 rs6787026 chr3:113162117 A/G cg18753928 chr3:113234510 CCDC52 -0.49 -5.27 -0.31 2.88e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC cis rs5769707 0.609 rs2007024 chr22:49988815 C/T cg05373962 chr22:49881684 NA -0.35 -5.22 -0.31 3.64e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs72634258 0.945 rs12745223 chr1:8094978 C/T cg00042356 chr1:8021962 PARK7 0.82 7.32 0.41 3.04e-12 Inflammatory bowel disease; CESC cis rs6500395 1.000 rs9930365 chr16:48682154 A/C cg04672837 chr16:48644449 N4BP1 0.51 6.36 0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3768617 0.510 rs3768620 chr1:183092237 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs28647808 1.000 rs7857017 chr9:136271101 A/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg17971929 chr21:40555470 PSMG1 1.05 16.62 0.71 5.49e-43 Cognitive function; CESC cis rs829883 0.659 rs12366275 chr12:98920276 G/C cg25150519 chr12:98850993 NA -0.65 -7.97 -0.44 4.6e-14 Colorectal adenoma (advanced); CESC cis rs533123 0.818 rs527931 chr1:29167161 T/C cg08366446 chr1:29138936 OPRD1 0.51 5.78 0.33 2.07e-8 Schizophrenia; CESC cis rs854765 0.647 rs854808 chr17:18006634 C/T cg09796270 chr17:17721594 SREBF1 0.4 5.39 0.31 1.56e-7 Total body bone mineral density; CESC cis rs6539267 0.847 rs12831519 chr12:106682917 A/G cg02476566 chr12:106696527 TCP11L2 0.67 6.85 0.39 5.05e-11 Tourette syndrome; CESC cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg23583168 chr7:148888333 NA -0.74 -10.66 -0.55 2.51e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2204008 0.580 rs11520047 chr12:38051778 T/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs11264213 0.591 rs274745 chr1:36538282 G/A cg27506609 chr1:36549197 TEKT2 -0.77 -7.45 -0.42 1.34e-12 Schizophrenia; CESC cis rs10504073 0.609 rs17644494 chr8:50019679 T/C cg00325661 chr8:49890786 NA 0.52 7.96 0.44 4.91e-14 Blood metabolite ratios; CESC cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg11366901 chr6:160182831 ACAT2 0.76 9.68 0.51 3.64e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs6466055 0.666 rs12671047 chr7:104999535 C/A cg04380332 chr7:105027541 SRPK2 -0.43 -5.62 -0.33 4.95e-8 Schizophrenia; CESC cis rs12477438 0.765 rs1115756 chr2:99659845 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs2276314 1.000 rs4799834 chr18:33566243 T/C cg19628046 chr18:33552617 C18orf21 0.54 5.96 0.34 7.82e-9 Endometriosis;Drug-induced torsades de pointes; CESC cis rs1577917 1.000 rs12190604 chr6:86716215 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.25 -0.36 1.66e-9 Response to antipsychotic treatment; CESC cis rs9905704 0.596 rs2526367 chr17:56470750 C/T cg12560992 chr17:57184187 TRIM37 -0.61 -5.75 -0.33 2.49e-8 Testicular germ cell tumor; CESC cis rs6982240 0.514 rs10089212 chr8:142265380 T/A cg00131261 chr8:142287264 NA -0.53 -7.31 -0.41 3.25e-12 Tonsillectomy; CESC cis rs17376456 0.877 rs10213956 chr5:93460839 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.11 0.3 6.27e-7 Diabetic retinopathy; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16857181 chr7:32931955 KBTBD2 -0.5 -7.15 -0.4 8.38e-12 Gambling; CESC cis rs7520050 0.743 rs61789988 chr1:46085242 G/C cg06784218 chr1:46089804 CCDC17 -0.31 -5.63 -0.33 4.69e-8 Red blood cell count;Reticulocyte count; CESC cis rs11252926 0.545 rs1551508 chr10:555469 A/G cg16386425 chr10:429943 DIP2C -0.4 -5.13 -0.3 5.63e-7 Psychosis in Alzheimer's disease; CESC cis rs9858542 1.000 rs2172252 chr3:49678307 A/T cg03060546 chr3:49711283 APEH -0.58 -6.81 -0.39 6.68e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs1814175 0.647 rs28456013 chr11:50047629 T/C cg03929089 chr4:120376271 NA -0.76 -9.77 -0.51 1.88e-19 Height; CESC cis rs67311347 1.000 rs12638199 chr3:40475285 A/G cg09455208 chr3:40491958 NA 0.44 7.53 0.42 8.04e-13 Renal cell carcinoma; CESC cis rs863345 0.967 rs9804005 chr1:158520414 A/G cg12129480 chr1:158549410 OR10X1 -0.33 -6.6 -0.38 2.19e-10 Pneumococcal bacteremia; CESC cis rs72781680 1.000 rs17762782 chr2:24126493 A/G cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs523522 1.000 rs523522 chr12:121020250 A/T cg12219531 chr12:120966889 COQ5 0.77 10.22 0.53 7.1e-21 High light scatter reticulocyte count; CESC trans rs7819412 0.521 rs10110684 chr8:11039159 G/C cg06636001 chr8:8085503 FLJ10661 -0.53 -6.16 -0.35 2.7e-9 Triglycerides; CESC cis rs9399137 0.507 rs13064 chr6:135287533 A/G cg24558204 chr6:135376177 HBS1L 0.7 9.64 0.51 4.87e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg07636037 chr3:49044803 WDR6 1.03 19.67 0.77 1.02e-53 Parkinson's disease; CESC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg11247378 chr22:39784982 NA -0.64 -9.76 -0.51 1.96e-19 Intelligence (multi-trait analysis); CESC trans rs9467711 0.659 rs66757203 chr6:26454956 C/T cg01620082 chr3:125678407 NA -0.81 -6.27 -0.36 1.44e-9 Autism spectrum disorder or schizophrenia; CESC cis rs4242434 0.892 rs11776549 chr8:22493124 C/T cg03733263 chr8:22462867 KIAA1967 1.01 13.25 0.63 4.38e-31 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs2737618 0.651 rs2816976 chr1:200081021 A/T cg21825944 chr1:200113062 NR5A2 -0.47 -7.23 -0.41 5.26e-12 Uric acid levels; CESC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg17372223 chr3:52568218 NT5DC2 0.44 6.55 0.37 2.98e-10 Bipolar disorder; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12344600 chr6:89769123 NA -0.52 -7.44 -0.42 1.41e-12 Gut microbiota (bacterial taxa); CESC cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg03538708 chr1:25844672 NA -0.42 -6.4 -0.37 6.96e-10 Erythrocyte sedimentation rate; CESC cis rs7621025 0.662 rs3856637 chr3:136391195 C/T cg15507776 chr3:136538369 TMEM22 0.42 5.47 0.32 1.06e-7 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs2243480 1.000 rs1873494 chr7:65649899 T/C cg12463550 chr7:65579703 CRCP -0.73 -5.66 -0.33 4.03e-8 Diabetic kidney disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01181084 chr8:43059863 NA 0.5 6.64 0.38 1.75e-10 Fibrinogen levels; CESC cis rs7542091 0.704 rs2142907 chr1:210039505 T/C cg09509183 chr1:209979624 IRF6 0.4 5.61 0.33 5.13e-8 Monobrow; CESC cis rs7914558 1.000 rs11191542 chr10:104824324 T/A cg04362960 chr10:104952993 NT5C2 0.48 6.45 0.37 5.35e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06336792 chr10:35415599 CREM -0.41 -6.07 -0.35 4.47e-9 Gambling; CESC cis rs1707322 0.752 rs7529699 chr1:46134634 C/T cg05343316 chr1:45956843 TESK2 0.51 6.24 0.36 1.7e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2070488 0.775 rs9838614 chr3:38537671 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.75 -11.59 -0.58 2.15e-25 Electrocardiographic conduction measures; CESC cis rs1707322 0.686 rs2152078 chr1:46055600 C/T cg03146154 chr1:46216737 IPP -0.77 -10.4 -0.54 1.77e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24037629 chr17:48226544 PPP1R9B -0.45 -6.53 -0.37 3.39e-10 Gambling; CESC cis rs4664308 0.694 rs4665140 chr2:160890710 T/A cg03641300 chr2:160917029 PLA2R1 -0.59 -8.54 -0.46 1.04e-15 Idiopathic membranous nephropathy; CESC cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.19 0.3 4.29e-7 Colonoscopy-negative controls vs population controls; CESC trans rs1557351 0.569 rs1942347 chr18:54724458 A/T cg11433624 chr6:7146702 RREB1 0.37 6.19 0.36 2.29e-9 Multiple sclerosis (age of onset); CESC cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg18016565 chr1:150552671 MCL1 -0.43 -7.13 -0.4 9.74e-12 Tonsillectomy; CESC cis rs933688 1.000 rs2367526 chr5:90740525 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 12.13 0.6 3.17e-27 Smoking behavior; CESC cis rs3845702 0.668 rs3856415 chr2:180807367 G/A cg01881094 chr2:180872142 CWC22 -1.05 -9.21 -0.49 9.96e-18 Schizophrenia; CESC cis rs8060686 0.641 rs12447931 chr16:68179195 C/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.02 -0.35 5.67e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg23711669 chr6:146136114 FBXO30 1.02 16.0 0.7 8.93e-41 Lobe attachment (rater-scored or self-reported); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg01698708 chr1:28100000 STX12 0.52 7.02 0.4 1.82e-11 Systemic lupus erythematosus; CESC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.4 -0.31 1.48e-7 Lung cancer; CESC cis rs8060686 0.546 rs7188350 chr16:68149316 T/C cg26727032 chr16:67993705 SLC12A4 -0.6 -8.17 -0.45 1.25e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs9868809 0.881 rs3821876 chr3:48668394 G/T cg07636037 chr3:49044803 WDR6 -0.63 -5.15 -0.3 5.14e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC trans rs1908814 0.516 rs10112958 chr8:11793140 A/G cg15556689 chr8:8085844 FLJ10661 0.54 6.58 0.37 2.47e-10 Neuroticism; CESC cis rs400736 0.602 rs6694154 chr1:8163520 G/A cg25007680 chr1:8021821 PARK7 -0.58 -7.78 -0.43 1.61e-13 Response to antidepressants and depression; CESC cis rs933688 1.000 rs60513756 chr5:90727692 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.17 13.81 0.65 4.68e-33 Smoking behavior; CESC cis rs7916697 0.520 rs10762201 chr10:70040111 A/G cg06988349 chr10:69991859 ATOH7 -0.31 -5.04 -0.3 8.45e-7 Optic disc area; CESC cis rs765787 0.530 rs2554457 chr15:45520926 G/A cg24006582 chr15:45444508 DUOX1 -0.57 -6.88 -0.39 4.36e-11 Uric acid levels; CESC cis rs4843747 0.605 rs4072779 chr16:88107290 C/T cg03395651 chr16:88107091 BANP 0.46 5.36 0.31 1.85e-7 Menopause (age at onset); CESC cis rs9584850 0.834 rs12869627 chr13:99120452 G/A cg22223119 chr13:99095684 FARP1 -0.36 -5.14 -0.3 5.29e-7 Neuroticism; CESC cis rs12142240 0.698 rs6684274 chr1:46810842 A/G cg00530320 chr1:46809349 NSUN4 -0.58 -7.83 -0.43 1.2e-13 Menopause (age at onset); CESC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg05564831 chr3:52568323 NT5DC2 0.44 6.66 0.38 1.6e-10 Bipolar disorder; CESC cis rs3820068 0.705 rs11589076 chr1:15827027 C/T cg18192808 chr1:15853278 DNAJC16 0.47 5.56 0.32 6.42e-8 Systolic blood pressure; CESC cis rs9814567 0.679 rs1880379 chr3:134330612 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.09 -0.3 6.84e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs72945132 0.660 rs7121703 chr11:70140296 C/T cg00319359 chr11:70116639 PPFIA1 0.78 7.67 0.43 3.32e-13 Coronary artery disease; CESC cis rs7666738 0.830 rs62318504 chr4:98935558 T/G cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13755630 chr13:27949051 NA -0.53 -6.15 -0.35 2.79e-9 Gut microbiome composition (summer); CESC cis rs662064 0.544 rs12402967 chr1:10617924 T/C cg20482658 chr1:10539492 PEX14 0.35 5.81 0.34 1.82e-8 Asthma; CESC trans rs11039798 1.000 rs9667626 chr11:48485877 T/C cg15704280 chr7:45808275 SEPT13 0.69 6.59 0.38 2.31e-10 Axial length; CESC cis rs6446731 0.517 rs2157093 chr4:3270913 C/G cg08886695 chr4:3369023 RGS12 0.38 5.49 0.32 9.46e-8 Mean platelet volume; CESC cis rs7246657 0.882 rs4803539 chr19:37897522 A/C cg23950597 chr19:37808831 NA -0.54 -6.02 -0.35 5.69e-9 Coronary artery calcification; CESC cis rs2204008 0.744 rs11519905 chr12:38222959 G/A cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.35e-10 Bladder cancer; CESC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg27297192 chr10:134578999 INPP5A 0.4 5.13 0.3 5.54e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg00677455 chr12:58241039 CTDSP2 0.52 6.55 0.37 3.04e-10 Multiple sclerosis; CESC cis rs72781680 0.611 rs72783619 chr2:24311607 G/A cg08917208 chr2:24149416 ATAD2B 0.55 5.22 0.31 3.56e-7 Lymphocyte counts; CESC cis rs863345 0.967 rs10908685 chr1:158524436 T/A cg12129480 chr1:158549410 OR10X1 -0.32 -6.53 -0.37 3.28e-10 Pneumococcal bacteremia; CESC trans rs61931739 0.534 rs1352206 chr12:34036668 G/A cg26384229 chr12:38710491 ALG10B 0.53 7.22 0.41 5.44e-12 Morning vs. evening chronotype; CESC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs11760633 0.672 rs10950377 chr7:1835894 C/G cg23422044 chr7:1970798 MAD1L1 0.45 5.32 0.31 2.26e-7 Coronary artery disease; CESC cis rs568617 0.859 rs1204650 chr11:65645580 A/C cg19792802 chr11:65647270 CTSW -0.35 -5.31 -0.31 2.33e-7 Crohn's disease; CESC trans rs2727020 0.615 rs35423199 chr11:49514914 T/C cg15704280 chr7:45808275 SEPT13 -0.95 -17.2 -0.73 5e-45 Coronary artery disease; CESC cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg17143192 chr8:8559678 CLDN23 0.78 8.81 0.48 1.65e-16 Obesity-related traits; CESC cis rs9325144 0.836 rs7489197 chr12:38750065 C/T cg26384229 chr12:38710491 ALG10B -0.48 -5.87 -0.34 1.28e-8 Morning vs. evening chronotype; CESC cis rs2742234 0.518 rs1254967 chr10:43690391 G/A cg15436174 chr10:43711423 RASGEF1A 0.5 5.87 0.34 1.27e-8 Hirschsprung disease; CESC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg25072359 chr17:41440525 NA 0.5 6.65 0.38 1.63e-10 Menopause (age at onset); CESC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg21770322 chr7:97807741 LMTK2 0.57 8.7 0.47 3.62e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs1957429 0.808 rs2357866 chr14:65336517 C/T cg23373153 chr14:65346875 NA 0.85 7.82 0.43 1.26e-13 Pediatric areal bone mineral density (radius); CESC cis rs2404602 0.716 rs67920045 chr15:76800084 G/A cg22467129 chr15:76604101 ETFA -0.36 -5.38 -0.31 1.64e-7 Blood metabolite levels; CESC cis rs9911578 0.900 rs717828 chr17:56535932 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.41 5.52 0.32 7.9e-8 Intelligence (multi-trait analysis); CESC cis rs2932538 0.885 rs6661642 chr1:113090109 T/C cg22162597 chr1:113214053 CAPZA1 0.55 6.91 0.39 3.58e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.64 0.43 3.85e-13 Prudent dietary pattern; CESC cis rs6032067 0.777 rs35476703 chr20:43802875 C/G cg11264863 chr20:43835661 SEMG1 0.5 5.38 0.31 1.62e-7 Blood protein levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03729288 chr17:7232752 NEURL4 -0.48 -6.1 -0.35 3.67e-9 Ulcerative colitis; CESC cis rs7656342 0.653 rs1401439 chr4:9832622 G/C cg00071950 chr4:10020882 SLC2A9 0.41 5.54 0.32 7.34e-8 Gut microbiota (bacterial taxa); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22110569 chr1:161009463 TSTD1;USF1 -0.46 -6.37 -0.36 8.29e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2243480 1.000 rs313798 chr7:65493031 A/G cg13147721 chr7:65941812 NA -0.91 -8.69 -0.47 3.87e-16 Diabetic kidney disease; CESC cis rs11264213 0.901 rs72661616 chr1:36370512 G/A cg27506609 chr1:36549197 TEKT2 0.66 5.59 0.32 5.62e-8 Schizophrenia; CESC cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg17366294 chr4:99064904 C4orf37 0.59 8.46 0.46 1.87e-15 Colonoscopy-negative controls vs population controls; CESC cis rs2204008 0.641 rs66876045 chr12:38205713 G/A cg13010199 chr12:38710504 ALG10B 0.51 6.45 0.37 5.18e-10 Bladder cancer; CESC cis rs2486288 0.656 rs8039153 chr15:45579813 T/C cg21132104 chr15:45694354 SPATA5L1 -0.59 -7.1 -0.4 1.12e-11 Glomerular filtration rate; CESC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg23281280 chr6:28129359 ZNF389 0.61 8.26 0.45 6.87e-15 Depression; CESC cis rs7959452 1.000 rs7959452 chr12:69735492 A/G cg22834771 chr12:69754056 YEATS4 -0.43 -5.62 -0.33 4.89e-8 Blood protein levels; CESC cis rs3008870 0.755 rs2815380 chr1:67510857 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.52 -6.55 -0.37 2.89e-10 Lymphocyte percentage of white cells; CESC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg11764359 chr7:65958608 NA -0.93 -14.62 -0.67 6.62e-36 Aortic root size; CESC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg19729930 chr2:74357872 NA 0.83 11.32 0.57 1.77e-24 Gestational age at birth (maternal effect); CESC cis rs6582630 0.502 rs11522899 chr12:38270637 T/C cg13010199 chr12:38710504 ALG10B 0.52 6.38 0.36 8.04e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg04166393 chr7:2884313 GNA12 0.58 6.96 0.39 2.73e-11 Height; CESC cis rs9911578 1.000 rs2009948 chr17:56611920 A/C cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.16 -0.3 4.83e-7 Intelligence (multi-trait analysis); CESC cis rs10911232 0.507 rs10911234 chr1:183053001 A/C ch.1.3577855R chr1:183094577 LAMC1 0.85 13.7 0.64 1.21e-32 Hypertriglyceridemia; CESC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg18190219 chr22:46762943 CELSR1 -0.56 -6.44 -0.37 5.69e-10 LDL cholesterol;Cholesterol, total; CESC cis rs9388451 0.869 rs7764016 chr6:126070789 T/G cg05901451 chr6:126070800 HEY2 -0.63 -8.82 -0.48 1.55e-16 Brugada syndrome; CESC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.79 13.18 0.63 7.6e-31 Personality dimensions; CESC cis rs9911578 0.967 rs8182277 chr17:57144367 C/T cg05425664 chr17:57184151 TRIM37 -0.53 -7.36 -0.41 2.28e-12 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11656663 chr1:202976539 TMEM183A;TMEM183B 0.57 6.09 0.35 3.92e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg16405210 chr4:1374714 KIAA1530 -0.9 -12.06 -0.6 5.62e-27 Longevity; CESC cis rs7937682 0.924 rs875258 chr11:111530607 C/A cg09085632 chr11:111637200 PPP2R1B -1.0 -16.56 -0.71 9.02e-43 Primary sclerosing cholangitis; CESC cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg03433033 chr1:76189801 ACADM 0.7 9.42 0.5 2.34e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs5758511 0.680 rs5758682 chr22:42645202 C/T cg00645731 chr22:42541494 CYP2D7P1 0.58 8.64 0.47 5.58e-16 Birth weight; CESC cis rs11608355 0.576 rs1477117 chr12:109888779 A/G cg05360138 chr12:110035743 NA -0.75 -7.75 -0.43 2.03e-13 Neuroticism; CESC cis rs2204008 0.599 rs2320526 chr12:38220405 T/A cg26384229 chr12:38710491 ALG10B 0.67 9.49 0.5 1.38e-18 Bladder cancer; CESC cis rs7524258 0.900 rs7551574 chr1:7314363 G/T cg07173049 chr1:7289937 CAMTA1 0.36 5.61 0.33 5.2e-8 Tourette's syndrome or obsessive-compulsive disorder; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg14528756 chr2:176862893 KIAA1715 0.41 6.66 0.38 1.56e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9322193 0.961 rs9027 chr6:149916057 T/A cg13206674 chr6:150067644 NUP43 0.38 5.42 0.32 1.31e-7 Lung cancer; CESC cis rs4481887 0.927 rs7524700 chr1:248472816 A/G cg00666640 chr1:248458726 OR2T12 0.36 6.12 0.35 3.33e-9 Common traits (Other); CESC cis rs965469 0.779 rs6051717 chr20:3270242 C/T cg25506879 chr20:3388711 C20orf194 -0.48 -5.29 -0.31 2.52e-7 IFN-related cytopenia; CESC cis rs4704187 0.663 rs4404659 chr5:74422119 T/C cg03227963 chr5:74354835 NA 0.31 5.7 0.33 3.22e-8 Response to amphetamines; CESC cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg01181863 chr3:195395398 SDHAP2 -0.48 -5.57 -0.32 6.34e-8 Pancreatic cancer; CESC cis rs4722166 0.630 rs13311155 chr7:22789789 A/C cg05472934 chr7:22766657 IL6 0.83 10.33 0.54 3.1e-21 Lung cancer; CESC cis rs7923609 0.967 rs7909269 chr10:65177766 G/A cg01631684 chr10:65280961 REEP3 -0.43 -5.32 -0.31 2.25e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg15352829 chr14:105391018 PLD4 -0.6 -10.49 -0.54 9.33e-22 Rheumatoid arthritis; CESC cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.83 8.86 0.48 1.15e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10504073 0.647 rs10435574 chr8:49996028 G/A cg00325661 chr8:49890786 NA 0.55 8.17 0.45 1.29e-14 Blood metabolite ratios; CESC cis rs116095464 0.558 rs6875291 chr5:264192 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.86e-15 Breast cancer; CESC cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg20503657 chr10:835505 NA 0.77 7.56 0.42 6.6e-13 Eosinophil percentage of granulocytes; CESC cis rs11785693 0.862 rs17435612 chr8:4987896 C/T cg26367366 chr8:4980734 NA -0.6 -6.25 -0.36 1.62e-9 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs7914558 0.966 rs4532960 chr10:104667406 C/T cg08650961 chr10:104748594 CNNM2 0.32 5.09 0.3 6.95e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs2404602 0.532 rs12591100 chr15:76700801 C/A cg00316803 chr15:76480434 C15orf27 0.37 5.54 0.32 7.33e-8 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08912058 chr1:6313858 GPR153 -0.52 -6.06 -0.35 4.68e-9 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06819704 chr5:159707559 CCNJL 0.44 6.01 0.35 6.27e-9 Fibrinogen levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08496016 chr9:99181722 ZNF367 0.47 6.29 0.36 1.3e-9 Gut microbiota (bacterial taxa); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03242101 chr16:67143792 C16orf70 -0.46 -6.07 -0.35 4.38e-9 Ulcerative colitis; CESC trans rs853679 0.607 rs13203816 chr6:28079598 T/C cg06606381 chr12:133084897 FBRSL1 -1.1 -8.36 -0.46 3.51e-15 Depression; CESC cis rs9790314 0.967 rs460165 chr3:161087710 G/A cg04691961 chr3:161091175 C3orf57 -0.4 -5.11 -0.3 6.19e-7 Morning vs. evening chronotype; CESC cis rs733592 0.524 rs10875741 chr12:48492922 A/C cg24011408 chr12:48396354 COL2A1 -0.5 -8.33 -0.46 4.47e-15 Plateletcrit; CESC cis rs847577 0.609 rs11768309 chr7:97773812 G/T cg21770322 chr7:97807741 LMTK2 0.87 15.35 0.69 1.77e-38 Breast cancer; CESC cis rs2267137 0.747 rs1963292 chr22:29805867 T/C cg07256473 chr22:29710276 RASL10A 0.38 5.53 0.32 7.68e-8 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC trans rs6054906 0.710 rs6117744 chr20:7265038 A/C cg02086952 chr17:54911499 DGKE 0.46 6.04 0.35 5.27e-9 Response to amphetamines; CESC cis rs12681288 0.644 rs2123058 chr8:1000304 A/G cg04851639 chr8:1020857 NA -0.32 -6.83 -0.39 5.89e-11 Schizophrenia; CESC cis rs9287719 0.934 rs6710033 chr2:10757677 C/T cg00105475 chr2:10696890 NA 0.37 5.4 0.31 1.52e-7 Prostate cancer; CESC cis rs2425143 1.000 rs73905926 chr20:34251982 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.17 0.3 4.59e-7 Blood protein levels; CESC cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 5.91 0.34 1.07e-8 Colorectal cancer; CESC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg13206674 chr6:150067644 NUP43 0.43 6.32 0.36 1.11e-9 Lung cancer; CESC cis rs2732480 0.557 rs2732454 chr12:48719677 T/C cg24011408 chr12:48396354 COL2A1 0.4 5.76 0.33 2.31e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg06028605 chr16:24865363 SLC5A11 0.53 7.87 0.44 9.04e-14 Intelligence (multi-trait analysis); CESC cis rs67311347 1.000 rs13324109 chr3:40460767 T/C cg09455208 chr3:40491958 NA 0.45 7.58 0.42 5.66e-13 Renal cell carcinoma; CESC cis rs1144333 1.000 rs78223982 chr1:76465203 T/C cg10523679 chr1:76189770 ACADM 0.55 5.14 0.3 5.24e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs55794721 0.509 rs7554255 chr1:25778106 C/T cg03538708 chr1:25844672 NA -0.41 -6.27 -0.36 1.48e-9 Plateletcrit;Mean corpuscular volume; CESC cis rs793571 0.614 rs347117 chr15:59000957 C/T cg05156742 chr15:59063176 FAM63B 0.58 7.66 0.43 3.42e-13 Schizophrenia; CESC cis rs7100689 0.646 rs1815650 chr10:82157464 C/T cg00277334 chr10:82204260 NA -0.46 -6.31 -0.36 1.19e-9 Post bronchodilator FEV1; CESC trans rs11989744 0.956 rs35693687 chr8:23575746 A/G cg03492747 chr16:86543808 FOXF1 0.68 7.53 0.42 7.9e-13 Waist-hip ratio; CESC cis rs2262909 0.962 rs411020 chr19:22231102 G/A cg11619707 chr19:22235551 ZNF257 -0.32 -5.26 -0.31 2.94e-7 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs6831352 0.879 rs29001229 chr4:100046823 A/G cg12011299 chr4:100065546 ADH4 -0.58 -6.41 -0.37 6.57e-10 Alcohol dependence; CESC cis rs7312933 0.702 rs10785333 chr12:42586470 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.5 -6.54 -0.37 3.15e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs72781680 0.898 rs116113042 chr2:23960194 G/T cg20701182 chr2:24300061 SF3B14 0.62 5.49 0.32 9.46e-8 Lymphocyte counts; CESC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg04518342 chr5:131593106 PDLIM4 0.4 6.15 0.35 2.9e-9 Breast cancer; CESC cis rs2439831 0.850 rs16950562 chr15:44036364 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.97 0.44 4.64e-14 Lung cancer in ever smokers; CESC cis rs11608355 0.515 rs2241204 chr12:109972037 G/A cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.9e-17 Neuroticism; CESC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg06456125 chr7:65229604 NA -0.47 -6.28 -0.36 1.36e-9 Aortic root size; CESC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg17143192 chr8:8559678 CLDN23 0.75 8.75 0.47 2.58e-16 Obesity-related traits; CESC cis rs10504229 0.817 rs55949560 chr8:58167603 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -8.99 -0.48 4.81e-17 Developmental language disorder (linguistic errors); CESC cis rs6540559 0.673 rs1073150 chr1:210017083 G/A cg21951975 chr1:209979733 IRF6 0.55 6.64 0.38 1.75e-10 Cleft lip with or without cleft palate; CESC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.83 0.55 6.96e-23 Height; CESC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg06456125 chr7:65229604 NA -0.4 -5.18 -0.3 4.45e-7 Aortic root size; CESC cis rs7927592 0.731 rs7108376 chr11:68347870 A/G cg16797656 chr11:68205561 LRP5 -0.48 -7.32 -0.41 2.97e-12 Total body bone mineral density; CESC cis rs60843830 0.661 rs6755432 chr2:106692 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.44 5.14 0.3 5.34e-7 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg22920501 chr2:26401640 FAM59B 0.81 9.89 0.52 7.79e-20 Gut microbiome composition (summer); CESC cis rs9486719 0.857 rs4346856 chr6:96880270 C/T cg06623918 chr6:96969491 KIAA0776 0.88 10.92 0.56 3.63e-23 Migraine;Coronary artery disease; CESC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs7772486 0.875 rs10872583 chr6:146396699 G/T cg23711669 chr6:146136114 FBXO30 -0.83 -11.96 -0.59 1.24e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg22823121 chr1:150693482 HORMAD1 0.47 6.58 0.37 2.48e-10 Melanoma; CESC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg27165867 chr14:105738592 BRF1 -0.53 -6.2 -0.36 2.13e-9 Mean platelet volume;Platelet distribution width; CESC cis rs7246657 0.882 rs10422667 chr19:37937876 T/C cg23950597 chr19:37808831 NA -0.62 -6.3 -0.36 1.24e-9 Coronary artery calcification; CESC cis rs9872999 1 rs9872999 chr3:133457514 C/T cg17775713 chr3:133465469 TF 0.33 5.91 0.34 1.04e-8 Iron status biomarkers; CESC cis rs9486715 0.867 rs6568428 chr6:96903604 A/G cg06623918 chr6:96969491 KIAA0776 0.93 14.44 0.66 2.86e-35 Headache; CESC cis rs3796352 0.892 rs58515094 chr3:52995575 C/T cg12962167 chr3:53033115 SFMBT1 0.62 5.13 0.3 5.63e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs3820068 0.705 rs4645983 chr1:15850603 G/A cg18192808 chr1:15853278 DNAJC16 0.47 5.81 0.34 1.75e-8 Systolic blood pressure; CESC cis rs9488822 0.702 rs6909746 chr6:116352750 C/T cg15226275 chr6:116381976 FRK 0.25 6.36 0.36 8.99e-10 Cholesterol, total;LDL cholesterol; CESC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg25985355 chr7:65971099 NA -0.31 -5.05 -0.3 8.31e-7 Aortic root size; CESC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.38 5.25 0.31 3.16e-7 Lymphocyte counts; CESC cis rs854765 0.583 rs11869536 chr17:17826528 T/A cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.93e-9 Total body bone mineral density; CESC cis rs7635838 0.617 rs346076 chr3:11292682 A/G cg00170343 chr3:11313890 ATG7 -0.63 -9.38 -0.5 3.07e-18 HDL cholesterol; CESC cis rs12477438 0.520 rs13018891 chr2:99755099 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.81 0.7 4.17e-40 Chronic sinus infection; CESC cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs225245 0.817 rs1476553 chr17:33994566 C/T cg05299278 chr17:33885742 SLFN14 0.36 5.14 0.3 5.34e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs10751667 0.666 rs4074231 chr11:978219 G/C cg06064525 chr11:970664 AP2A2 -0.47 -9.12 -0.49 1.9e-17 Alzheimer's disease (late onset); CESC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg03806693 chr22:41940476 POLR3H 1.04 12.12 0.6 3.49e-27 Vitiligo; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17099815 chr15:31217407 MTMR15 -0.48 -6.4 -0.37 7.15e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7937682 0.632 rs11214015 chr11:111719417 A/T cg22437258 chr11:111473054 SIK2 0.51 5.74 0.33 2.57e-8 Primary sclerosing cholangitis; CESC cis rs754466 0.651 rs10762767 chr10:79645070 C/A cg17075019 chr10:79541650 NA -0.84 -12.55 -0.61 1.15e-28 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 11.46 0.58 5.9e-25 Platelet count; CESC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg08888203 chr3:10149979 C3orf24 -0.44 -5.86 -0.34 1.36e-8 Alzheimer's disease; CESC cis rs10788264 0.538 rs1998344 chr10:124030137 A/G cg09507567 chr10:124027408 NA 0.39 5.78 0.33 2.08e-8 Total body bone mineral density; CESC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg08736216 chr1:53307985 ZYG11A 0.4 6.33 0.36 1.04e-9 Monocyte count; CESC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg07701084 chr6:150067640 NUP43 0.49 6.81 0.39 6.47e-11 Lung cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02978827 chr13:48877687 RB1 -0.49 -6.51 -0.37 3.73e-10 Asthma; CESC trans rs72766638 1.000 rs72766638 chr9:136931778 C/A cg10765909 chr12:53715428 AAAS -0.73 -6.51 -0.37 3.82e-10 Mosquito bite size; CESC cis rs2361718 1.000 rs2361718 chr17:78103466 C/T cg20811857 chr17:78079795 GAA -0.32 -5.03 -0.3 8.96e-7 Yeast infection; CESC cis rs2243480 0.901 rs73148097 chr7:65431787 A/C cg13147721 chr7:65941812 NA -0.9 -8.65 -0.47 4.98e-16 Diabetic kidney disease; CESC cis rs17125944 0.505 rs77433996 chr14:53212263 G/A cg13660082 chr14:53194042 PSMC6 -0.66 -6.03 -0.35 5.46e-9 Alzheimer's disease (late onset); CESC cis rs96067 0.652 rs274132 chr1:36581978 C/T cg27506609 chr1:36549197 TEKT2 0.33 5.21 0.3 3.78e-7 Corneal structure; CESC cis rs7618501 1.000 rs7618501 chr3:49772647 A/G cg24308560 chr3:49941425 MST1R 0.5 6.81 0.39 6.38e-11 Intelligence (multi-trait analysis); CESC cis rs6088580 0.634 rs6087579 chr20:32985155 A/G cg08999081 chr20:33150536 PIGU -0.65 -11.43 -0.57 7.18e-25 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03428881 chr7:150725579 ABCB8 0.6 6.9 0.39 3.79e-11 Gut microbiome composition (summer); CESC cis rs4642101 0.737 rs6767504 chr3:12826667 C/T cg05775895 chr3:12838266 CAND2 0.38 5.69 0.33 3.38e-8 QRS complex (12-leadsum); CESC cis rs8014204 0.935 rs4903267 chr14:75360419 G/T cg08847533 chr14:75593920 NEK9 -0.46 -5.68 -0.33 3.46e-8 Caffeine consumption; CESC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg24829409 chr8:58192753 C8orf71 -0.69 -9.06 -0.49 2.93e-17 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg26338869 chr17:61819248 STRADA 0.69 9.18 0.49 1.31e-17 Prudent dietary pattern; CESC cis rs9894429 0.789 rs6565611 chr17:79598319 T/C cg18240062 chr17:79603768 NPLOC4 0.9 13.13 0.63 1.15e-30 Eye color traits; CESC cis rs7267979 0.932 rs431579 chr20:25470056 T/C cg08601574 chr20:25228251 PYGB 0.37 5.37 0.31 1.76e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs7666738 0.606 rs4577589 chr4:99087858 A/G cg05340658 chr4:99064831 C4orf37 0.65 8.94 0.48 6.63e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg17971929 chr21:40555470 PSMG1 -0.85 -12.26 -0.6 1.12e-27 Cognitive function; CESC cis rs12765878 1.000 rs1980653 chr10:105654164 A/G cg24587175 chr10:105670608 OBFC1 0.34 5.54 0.32 7.37e-8 Coronary artery disease; CESC cis rs13223928 0.554 rs13438334 chr7:3156956 G/A cg19214707 chr7:3157722 NA -0.43 -5.78 -0.33 2.09e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC cis rs4423214 0.592 rs3829251 chr11:71194559 G/A cg05163923 chr11:71159392 DHCR7 -0.62 -6.12 -0.35 3.29e-9 Vitamin D levels; CESC cis rs15676 0.838 rs2280841 chr9:131600111 T/C cg00228799 chr9:131580591 ENDOG 0.55 7.06 0.4 1.43e-11 Blood metabolite levels; CESC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg18099408 chr3:52552593 STAB1 -0.36 -6.12 -0.35 3.3e-9 Electroencephalogram traits; CESC cis rs7264396 0.563 rs2425089 chr20:34304036 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.7 0.38 1.23e-10 Total cholesterol levels; CESC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.03 16.25 0.71 1.1e-41 Height; CESC cis rs7020830 0.830 rs12554976 chr9:37244505 G/T cg14294708 chr9:37120828 ZCCHC7 1.2 22.49 0.81 2.13e-63 Schizophrenia; CESC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.77 10.14 0.53 1.23e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10078 0.898 rs2241598 chr5:438564 C/T cg08916839 chr5:415575 AHRR -0.41 -5.32 -0.31 2.22e-7 Fat distribution (HIV); CESC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg10792982 chr14:105748885 BRF1 0.41 5.26 0.31 2.96e-7 Mean platelet volume;Platelet distribution width; CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg18337363 chr3:52569053 NT5DC2 0.31 6.1 0.35 3.71e-9 Bipolar disorder; CESC cis rs2637266 0.703 rs846639 chr10:78524428 A/G cg18941641 chr10:78392320 NA 0.38 7.56 0.42 6.56e-13 Pulmonary function; CESC cis rs1580019 0.961 rs2392056 chr7:32498953 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.11 0.53 1.5e-20 Cognitive ability; CESC cis rs7649275 0.882 rs877257 chr3:53784503 A/G cg21503701 chr3:53781065 CACNA1D -0.39 -5.19 -0.3 4.28e-7 Trans fatty acid levels; CESC cis rs6499255 1.000 rs4497676 chr16:69814950 G/A cg15192750 chr16:69999425 NA 0.44 5.41 0.32 1.41e-7 IgE levels; CESC cis rs6815814 0.950 rs5743557 chr4:38806827 G/A cg02016764 chr4:38805732 TLR1 -0.63 -7.2 -0.4 6.39e-12 Breast cancer; CESC cis rs644799 0.542 rs10831415 chr11:95466159 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.65 9.13 0.49 1.83e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9612 1.000 rs346526 chr19:44259565 A/G cg08581076 chr19:44259116 C19orf61 0.52 6.14 0.35 2.96e-9 Exhaled nitric oxide output; CESC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg00431813 chr7:1051703 C7orf50 -0.39 -6.06 -0.35 4.71e-9 Longevity;Endometriosis; CESC cis rs2228479 0.867 rs73276534 chr16:89950557 A/G cg04013166 chr16:89971882 TCF25 0.73 8.84 0.48 1.38e-16 Skin colour saturation; CESC cis rs3008870 0.883 rs2755249 chr1:67493662 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.01 13.63 0.64 1.99e-32 Lymphocyte percentage of white cells; CESC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg06028605 chr16:24865363 SLC5A11 -0.53 -7.96 -0.44 5.15e-14 Intelligence (multi-trait analysis); CESC cis rs561341 1.000 rs508192 chr17:30315147 C/T cg12193833 chr17:30244370 NA 0.68 6.08 0.35 4.11e-9 Hip circumference adjusted for BMI; CESC cis rs72781680 1.000 rs72796327 chr2:24140372 T/C cg08917208 chr2:24149416 ATAD2B 1.02 9.22 0.49 9.42e-18 Lymphocyte counts; CESC cis rs7584330 0.910 rs880932 chr2:238396963 A/G cg11271282 chr2:238384023 NA 0.48 5.7 0.33 3.22e-8 Prostate cancer; CESC cis rs9911578 0.967 rs9894274 chr17:56977919 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.41 5.41 0.32 1.38e-7 Intelligence (multi-trait analysis); CESC cis rs7953249 0.618 rs2650000 chr12:121388962 G/T cg02403541 chr12:121454288 C12orf43 0.51 6.73 0.38 1.04e-10 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs72781680 0.848 rs72798057 chr2:23976731 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.54 0.32 7.13e-8 Lymphocyte counts; CESC cis rs7598759 0.527 rs7571691 chr2:232369401 C/T cg19187155 chr2:232395269 NMUR1 0.61 10.12 0.53 1.46e-20 Noise-induced hearing loss; CESC cis rs6674176 0.932 rs7412307 chr1:44433864 C/G cg12908607 chr1:44402522 ARTN 0.46 6.32 0.36 1.11e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg07701084 chr6:150067640 NUP43 0.44 5.91 0.34 1.04e-8 Lung cancer; CESC cis rs9910055 0.529 rs425038 chr17:42182028 T/C cg19774624 chr17:42201019 HDAC5 0.66 9.1 0.49 2.22e-17 Total body bone mineral density; CESC cis rs3008870 0.755 rs11208974 chr1:67398119 A/T cg02640540 chr1:67518911 SLC35D1 0.46 5.56 0.32 6.52e-8 Lymphocyte percentage of white cells; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10593459 chr1:44447478 B4GALT2 0.44 6.41 0.37 6.63e-10 Fibrinogen levels; CESC cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg02574844 chr11:5959923 NA -0.43 -5.41 -0.32 1.42e-7 DNA methylation (variation); CESC cis rs7605827 0.930 rs7568459 chr2:15691026 C/T cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg25767906 chr1:53392781 SCP2 -0.57 -7.56 -0.42 6.52e-13 Monocyte count; CESC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.51 5.9 0.34 1.11e-8 Schizophrenia; CESC cis rs910316 0.967 rs2010678 chr14:75567178 C/T cg08847533 chr14:75593920 NEK9 1.01 19.43 0.77 6.73e-53 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12035827 chr1:10855226 CASZ1 0.66 7.56 0.42 6.42e-13 Gut microbiome composition (summer); CESC cis rs3096299 0.967 rs28575874 chr16:89469890 C/T cg08822215 chr16:89438651 ANKRD11 -0.39 -5.9 -0.34 1.13e-8 Multiple myeloma (IgH translocation); CESC cis rs672059 0.565 rs525410 chr1:183176430 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.52 -6.98 -0.39 2.36e-11 Hypertriglyceridemia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg21149582 chr1:10532838 DFFA -0.51 -7.42 -0.41 1.59e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2281727 0.500 rs2169356 chr17:2138016 A/T cg16513277 chr17:2031491 SMG6 -0.63 -8.88 -0.48 1.06e-16 Coronary artery disease;Body mass index; CESC cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg11752832 chr7:134001865 SLC35B4 0.52 6.64 0.38 1.76e-10 Mean platelet volume; CESC cis rs2455799 0.573 rs2455836 chr3:15754538 A/G cg09340198 chr3:15902540 ANKRD28 -0.32 -5.09 -0.3 6.67e-7 Mean platelet volume; CESC cis rs4867766 0.871 rs2242419 chr5:173959332 C/T cg20434911 chr5:173954559 NA 0.56 6.16 0.35 2.72e-9 Stroke; CESC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg05340658 chr4:99064831 C4orf37 0.82 13.07 0.63 1.82e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs10014284 chr4:98681951 G/C cg03467027 chr4:99064603 C4orf37 0.44 5.39 0.31 1.52e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4953318 0.694 rs3768747 chr2:46352058 G/T cg12428440 chr2:46370979 PRKCE -0.48 -6.83 -0.39 5.66e-11 Red blood cell count;Hematocrit;Red blood cell traits; CESC cis rs863345 0.625 rs10908655 chr1:158460899 C/T cg12129480 chr1:158549410 OR10X1 -0.36 -7.15 -0.4 8.67e-12 Pneumococcal bacteremia; CESC cis rs7274811 0.652 rs293732 chr20:31975090 G/A cg21523528 chr20:32077966 CBFA2T2 -0.55 -6.42 -0.37 6.26e-10 Height; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13445258 chr3:128369860 RPN1 -0.45 -6.52 -0.37 3.52e-10 Gambling; CESC cis rs10411936 0.692 rs62118141 chr19:16602808 T/C cg10248733 chr19:16607483 C19orf44;CALR3 0.53 6.5 0.37 3.88e-10 White blood cell count;Multiple sclerosis; CESC cis rs3091242 0.933 rs909833 chr1:25754140 C/G cg27572855 chr1:25598939 RHD 0.43 7.14 0.4 9.07e-12 Erythrocyte sedimentation rate; CESC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.08 0.49 2.58e-17 Tonsillectomy; CESC cis rs5769707 0.609 rs739247 chr22:49996657 T/C cg20744362 chr22:50050164 C22orf34 0.37 5.39 0.31 1.53e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs778371 1.000 rs778371 chr2:233743109 A/G cg08000102 chr2:233561755 GIGYF2 -0.8 -11.14 -0.56 6.71e-24 Schizophrenia; CESC cis rs2760061 0.583 rs1636195 chr1:228211589 T/C cg02753203 chr1:228287806 NA 0.79 10.96 0.56 2.59e-23 Diastolic blood pressure; CESC cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg26408565 chr15:76604113 ETFA 0.44 6.44 0.37 5.72e-10 Blood metabolite levels; CESC cis rs9929218 0.906 rs33965787 chr16:68828173 G/A cg02972257 chr16:68554789 NA 0.44 5.25 0.31 3.2e-7 Colorectal cancer; CESC cis rs11792861 0.816 rs28361186 chr9:111704064 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 6.67 0.38 1.49e-10 Menarche (age at onset); CESC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg04772025 chr11:68637568 NA 0.58 6.73 0.38 1.06e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg18180107 chr4:99064573 C4orf37 0.42 5.3 0.31 2.44e-7 Colonoscopy-negative controls vs population controls; CESC cis rs57506017 0.585 rs6460898 chr7:12252893 A/G cg23422036 chr7:12250390 TMEM106B 0.38 5.12 0.3 5.88e-7 Neuroticism; CESC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg22920501 chr2:26401640 FAM59B -0.91 -10.33 -0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs7599312 0.532 rs16848751 chr2:213389346 A/G cg16329650 chr2:213403929 ERBB4 0.41 5.43 0.32 1.3e-7 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9583531 0.600 rs4773241 chr13:111363021 A/G cg15841412 chr13:111365552 ING1 0.53 6.72 0.38 1.1e-10 Coronary artery disease; CESC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg00080972 chr5:178986291 RUFY1 -0.44 -6.93 -0.39 3.24e-11 Lung cancer; CESC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg02951883 chr7:2050386 MAD1L1 -0.46 -5.89 -0.34 1.14e-8 Bipolar disorder and schizophrenia; CESC cis rs10779751 0.922 rs11121708 chr1:11307253 G/C cg08854313 chr1:11322531 MTOR 0.8 10.83 0.55 6.99e-23 Body mass index; CESC cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg04450456 chr4:17643702 FAM184B 0.41 5.77 0.33 2.18e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9611565 0.649 rs202614 chr22:41822150 A/C cg17376030 chr22:41985996 PMM1 -0.76 -8.01 -0.44 3.71e-14 Vitiligo; CESC cis rs13095912 0.785 rs6444076 chr3:185321405 T/C cg11274856 chr3:185301563 NA 0.4 5.99 0.35 6.69e-9 Systolic blood pressure; CESC cis rs7044106 0.615 rs10818470 chr9:123359204 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 11.1 0.56 9.3e-24 Hip circumference adjusted for BMI; CESC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg17971929 chr21:40555470 PSMG1 1.08 16.45 0.71 2.24e-42 Cognitive function; CESC cis rs4974559 1.000 rs4974559 chr4:1380848 C/T cg02980000 chr4:1222292 CTBP1 -0.71 -8.95 -0.48 6.25e-17 Systolic blood pressure; CESC cis rs17253792 0.822 rs17685078 chr14:56127202 T/C cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC cis rs3126085 0.935 rs12027807 chr1:152253726 C/G cg03465714 chr1:152285911 FLG -0.46 -5.75 -0.33 2.42e-8 Atopic dermatitis; CESC cis rs1953600 1.000 rs2789679 chr10:81907884 A/T cg00277334 chr10:82204260 NA -0.51 -7.23 -0.41 5.11e-12 Sarcoidosis; CESC cis rs77106637 0.860 rs7129793 chr11:72455885 C/T cg03713592 chr11:72463424 ARAP1 1.3 11.0 0.56 2e-23 Type 2 diabetes; CESC cis rs741677 0.663 rs405203 chr17:491009 A/G cg15660573 chr17:549704 VPS53 0.43 5.65 0.33 4.24e-8 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); CESC cis rs9467711 0.606 rs9393714 chr6:26373740 G/T cg12826209 chr6:26865740 GUSBL1 0.62 5.34 0.31 1.96e-7 Autism spectrum disorder or schizophrenia; CESC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg12311346 chr5:56204834 C5orf35 -0.64 -7.96 -0.44 4.98e-14 Initial pursuit acceleration; CESC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg09359103 chr1:154839909 KCNN3 -0.66 -12.64 -0.61 5.4e-29 Prostate cancer; CESC cis rs12142240 0.698 rs41294476 chr1:46818374 C/A cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7178909 0.872 rs7174330 chr15:90434579 C/T cg19708238 chr15:90437601 AP3S2 -0.4 -5.65 -0.33 4.15e-8 Common traits (Other); CESC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg12310025 chr6:25882481 NA -0.45 -6.26 -0.36 1.57e-9 Intelligence (multi-trait analysis); CESC cis rs897984 0.542 rs11865038 chr16:31095171 C/T cg02466173 chr16:30829666 NA -0.4 -6.75 -0.38 9.46e-11 Dementia with Lewy bodies; CESC cis rs7223966 1.000 rs8073373 chr17:61703320 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.46 -0.32 1.1e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2797160 1.000 rs1935774 chr6:125996661 A/G cg05901451 chr6:126070800 HEY2 0.41 6.09 0.35 4e-9 Endometrial cancer; CESC cis rs1878931 0.597 rs37814 chr16:3455247 C/T cg22508957 chr16:3507546 NAT15 0.4 5.29 0.31 2.57e-7 Body mass index (adult); CESC cis rs79387448 0.638 rs78123896 chr2:103075417 T/C cg09003973 chr2:102972529 NA 0.78 6.46 0.37 5e-10 Gut microbiota (bacterial taxa); CESC cis rs7116495 1.000 rs17161966 chr11:71815308 T/C cg26138937 chr11:71823887 C11orf51 0.85 6.85 0.39 5.03e-11 Severe influenza A (H1N1) infection; CESC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.86 0.34 1.41e-8 Bipolar disorder; CESC cis rs7267979 0.833 rs4619688 chr20:25244101 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.09 0.68 1.41e-37 Liver enzyme levels (alkaline phosphatase); CESC trans rs9325144 0.647 rs11168741 chr12:38989120 C/T cg23762105 chr12:34175262 ALG10 0.48 6.33 0.36 1.03e-9 Morning vs. evening chronotype; CESC cis rs17376456 0.809 rs10476602 chr5:93445255 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.57 5.08 0.3 7.18e-7 Diabetic retinopathy; CESC cis rs4789693 0.938 rs4789694 chr17:80428099 A/C cg04308225 chr17:80449738 NA -0.45 -5.23 -0.31 3.52e-7 Glucocorticoid-induced osteonecrosis; CESC cis rs4409675 0.576 rs11247706 chr1:28213983 G/C cg23691781 chr1:28212827 C1orf38 0.29 5.69 0.33 3.41e-8 Corneal astigmatism; CESC cis rs9486719 1.000 rs2499816 chr6:96878206 C/T cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs11249608 0.548 rs17078991 chr5:178459426 A/C cg21905437 chr5:178450457 ZNF879 0.58 8.09 0.45 2.16e-14 Pubertal anthropometrics; CESC cis rs1256061 0.624 rs1152578 chr14:64697037 T/C cg23250157 chr14:64679961 SYNE2 0.52 7.37 0.41 2.22e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg18876405 chr7:65276391 NA -0.54 -7.06 -0.4 1.46e-11 Aortic root size; CESC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg00475322 chr7:917719 C7orf20 0.46 5.1 0.3 6.42e-7 Cerebrospinal P-tau181p levels; CESC cis rs17376456 0.877 rs7701974 chr5:93311417 C/T cg25358565 chr5:93447407 FAM172A 1.07 10.61 0.55 3.7e-22 Diabetic retinopathy; CESC cis rs9814567 1.000 rs4334685 chr3:134304335 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.47 -0.32 1.07e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs2766692 1.000 rs4905941 chr14:100725438 A/G cg14866419 chr14:100704911 YY1 0.62 8.4 0.46 2.7e-15 Electroencephalographic traits in alcoholism; CESC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg09323728 chr8:95962352 TP53INP1 -0.42 -9.2 -0.49 1.09e-17 Type 2 diabetes; CESC cis rs5769765 0.955 rs5770750 chr22:50276828 A/G cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC trans rs561341 0.941 rs72825736 chr17:30330286 G/A cg27661571 chr11:113659931 NA -0.82 -7.6 -0.42 5.24e-13 Hip circumference adjusted for BMI; CESC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg12756686 chr19:29218302 NA 0.44 6.49 0.37 4.09e-10 Methadone dose in opioid dependence; CESC cis rs208520 0.909 rs62414636 chr6:67015723 T/G cg07460842 chr6:66804631 NA 0.84 8.13 0.45 1.67e-14 Exhaled nitric oxide output; CESC cis rs34779708 0.966 rs4934539 chr10:35472199 A/G cg03585969 chr10:35415529 CREM 0.77 10.56 0.54 5.56e-22 Inflammatory bowel disease;Crohn's disease; CESC cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg26116260 chr4:7069785 GRPEL1 0.99 14.52 0.67 1.52e-35 Monocyte percentage of white cells; CESC cis rs12145833 0.596 rs1060643 chr1:243429976 G/C cg02356786 chr1:243265016 LOC731275 0.74 5.59 0.32 5.53e-8 Obesity (early onset extreme); CESC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs61841072 0.602 rs11589245 chr1:243131106 C/T cg02356786 chr1:243265016 LOC731275 0.41 5.26 0.31 2.97e-7 Schizophrenia; CESC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.49 -5.89 -0.34 1.15e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs796364 0.616 rs2689762 chr2:200687204 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.57 5.25 0.31 3.09e-7 Schizophrenia; CESC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg18099408 chr3:52552593 STAB1 -0.32 -5.41 -0.32 1.43e-7 Electroencephalogram traits; CESC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.09 -0.4 1.25e-11 Personality dimensions; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12784241 chr6:158402508 SYNJ2 -0.41 -6.21 -0.36 2.09e-9 Fibrinogen levels; CESC cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg26408565 chr15:76604113 ETFA -0.42 -6.08 -0.35 4.19e-9 Blood metabolite levels; CESC cis rs7208859 0.673 rs216420 chr17:28938508 C/T cg04154034 chr17:28927549 LRRC37B2 0.67 5.93 0.34 9.32e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg23281280 chr6:28129359 ZNF389 -0.47 -6.61 -0.38 2.13e-10 Depression; CESC cis rs367943 0.501 rs960691 chr5:112971654 G/C cg12552261 chr5:112820674 MCC 0.44 5.63 0.33 4.63e-8 Type 2 diabetes; CESC cis rs4965006 1.000 rs4965006 chr12:132419533 A/G cg00588090 chr12:132412438 PUS1 -0.51 -7.17 -0.4 7.48e-12 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs61784830 0.710 rs61783251 chr1:46368087 G/C cg06784218 chr1:46089804 CCDC17 0.48 5.42 0.32 1.37e-7 Iron status biomarkers (total iron binding capacity); CESC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg22823121 chr1:150693482 HORMAD1 0.4 5.7 0.33 3.2e-8 Melanoma; CESC cis rs2235642 0.821 rs2281234 chr16:1602938 A/G cg03771183 chr16:1608904 IFT140 0.4 5.9 0.34 1.12e-8 Coronary artery disease; CESC cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg18180107 chr4:99064573 C4orf37 0.41 5.35 0.31 1.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7917772 0.582 rs7899004 chr10:104341435 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.4 -5.44 -0.32 1.19e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs57506017 0.585 rs5011436 chr7:12268758 A/C cg23422036 chr7:12250390 TMEM106B 0.38 5.16 0.3 4.76e-7 Neuroticism; CESC cis rs1465370 0.720 rs2402995 chr7:130016595 C/T cg04743876 chr7:130013617 NA 0.31 5.88 0.34 1.23e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24582500 chr10:131934763 GLRX3 0.54 6.49 0.37 4.18e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01077841 chr13:99228499 STK24 0.56 6.35 0.36 9.36e-10 Gut microbiome composition (summer); CESC cis rs12477438 0.798 rs12473029 chr2:99637961 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -11.02 -0.56 1.73e-23 Chronic sinus infection; CESC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 9.54 0.51 1.02e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1707322 0.963 rs4508055 chr1:46257731 A/T cg05343316 chr1:45956843 TESK2 0.51 6.25 0.36 1.59e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2425143 1.000 rs78877130 chr20:34344947 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -7.66 -0.43 3.49e-13 Blood protein levels; CESC cis rs9768139 0.708 rs896780 chr7:158113972 C/T cg06219351 chr7:158114137 PTPRN2 -0.56 -8.83 -0.48 1.49e-16 Calcium levels; CESC cis rs734999 0.545 rs7368072 chr1:2556125 C/T cg18854424 chr1:2615690 NA 0.3 5.88 0.34 1.2e-8 Ulcerative colitis; CESC cis rs8077577 0.747 rs62072507 chr17:18172335 G/A cg16794390 chr17:18148240 FLII 0.43 6.54 0.37 3.16e-10 Obesity-related traits; CESC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg17971929 chr21:40555470 PSMG1 1.04 15.93 0.7 1.5e-40 Cognitive function; CESC cis rs2070488 0.775 rs7647657 chr3:38573746 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.76 -11.21 -0.57 3.97e-24 Electrocardiographic conduction measures; CESC cis rs12477438 0.501 rs11688004 chr2:99735052 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.44 0.64 9.76e-32 Chronic sinus infection; CESC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg22590775 chr19:49891494 CCDC155 0.6 6.99 0.39 2.19e-11 Multiple sclerosis; CESC cis rs2228479 0.867 rs34272502 chr16:89949000 G/C cg14709524 chr16:89940631 TCF25 0.74 5.75 0.33 2.43e-8 Skin colour saturation; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15754109 chr8:67974431 COPS5 -0.51 -6.81 -0.39 6.6e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2840044 0.534 rs2124246 chr17:33885431 G/A cg05299278 chr17:33885742 SLFN14 0.42 5.95 0.34 8.31e-9 Response to radiotherapy in cancer (late toxicity); CESC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg14159672 chr1:205819179 PM20D1 -0.4 -5.22 -0.31 3.58e-7 White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.2 0.3 4.07e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11112613 0.775 rs10507194 chr12:105959488 G/A cg03607813 chr12:105948248 NA 0.57 6.35 0.36 9.12e-10 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs2303759 0.676 rs10426452 chr19:49907690 G/A cg22590775 chr19:49891494 CCDC155 0.51 6.16 0.35 2.67e-9 Multiple sclerosis; CESC cis rs13242816 1.000 rs56275709 chr7:116108489 A/G cg04696780 chr7:116139425 CAV2 -0.62 -5.69 -0.33 3.31e-8 P wave duration; CESC cis rs2262909 0.962 rs11669110 chr19:22296485 A/G cg11619707 chr19:22235551 ZNF257 0.35 5.61 0.33 5.04e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CESC cis rs1881797 1.000 rs10925069 chr1:247681313 C/T cg21399703 chr1:247681439 NA -0.6 -8.04 -0.44 2.95e-14 Acute lymphoblastic leukemia (childhood); CESC cis rs6582630 0.519 rs8189623 chr12:38351436 G/A cg13010199 chr12:38710504 ALG10B 0.48 6.06 0.35 4.62e-9 Drug-induced liver injury (flucloxacillin); CESC trans rs10463316 0.894 rs7707745 chr5:150765198 G/T cg24389359 chr12:111284228 CCDC63 -0.34 -6.14 -0.35 3.06e-9 Metabolite levels (Pyroglutamine); CESC cis rs9300255 0.739 rs1402275 chr12:123750895 A/G cg19016782 chr12:123741754 C12orf65 -0.49 -7.09 -0.4 1.22e-11 Neutrophil percentage of white cells; CESC cis rs11758351 0.518 rs79922979 chr6:26224975 A/G cg01420254 chr6:26195488 NA 0.77 8.49 0.46 1.48e-15 Gout;Renal underexcretion gout; CESC cis rs2302190 0.882 rs1974586 chr17:56640731 C/T cg25885038 chr17:56607967 SEPT4 -0.4 -5.43 -0.32 1.27e-7 Vitamin D levels; CESC cis rs113835537 0.529 rs2305535 chr11:66272237 A/G cg22134325 chr11:66188745 NPAS4 -0.33 -5.05 -0.3 8.22e-7 Airway imaging phenotypes; CESC cis rs7824557 0.527 rs2736298 chr8:11235136 C/G cg21775007 chr8:11205619 TDH -0.53 -7.87 -0.44 8.89e-14 Retinal vascular caliber; CESC cis rs6662572 0.737 rs11584814 chr1:46504389 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.2 0.3 4.05e-7 Blood protein levels; CESC cis rs1008375 0.966 rs4698642 chr4:17679174 A/T cg02297831 chr4:17616191 MED28 0.44 5.66 0.33 4.03e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC cis rs8017423 0.669 rs7153190 chr14:90703904 T/G cg14092571 chr14:90743983 NA -0.56 -8.3 -0.45 5.2e-15 Mortality in heart failure; CESC cis rs2933343 0.601 rs1680758 chr3:128594897 T/C cg24203234 chr3:128598194 ACAD9 0.43 5.88 0.34 1.23e-8 IgG glycosylation; CESC cis rs2243480 1.000 rs35421653 chr7:65363429 C/A cg13147721 chr7:65941812 NA -0.88 -8.2 -0.45 1.03e-14 Diabetic kidney disease; CESC cis rs6439153 0.933 rs9822511 chr3:128705567 G/A cg25356066 chr3:128598488 ACAD9 0.54 7.0 0.39 2.12e-11 Pneumococcal bacteremia; CESC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg03388025 chr16:89894329 SPIRE2 0.41 7.99 0.44 4.07e-14 Vitiligo; CESC cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg11752832 chr7:134001865 SLC35B4 0.54 6.89 0.39 3.94e-11 Mean platelet volume; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg23912435 chr1:150601613 ENSA -0.37 -6.1 -0.35 3.84e-9 Vertical cup-disc ratio; CESC cis rs7671266 0.747 rs6827946 chr4:10151335 T/C cg11266682 chr4:10021025 SLC2A9 -0.43 -5.43 -0.32 1.26e-7 Cardiovascular disease risk factors; CESC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg00784671 chr22:46762841 CELSR1 -0.48 -5.59 -0.32 5.72e-8 LDL cholesterol;Cholesterol, total; CESC cis rs1580019 0.961 rs4460271 chr7:32496503 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.15 0.53 1.14e-20 Cognitive ability; CESC cis rs35110281 0.591 rs86138 chr21:44932398 G/A cg01579765 chr21:45077557 HSF2BP -0.52 -9.14 -0.49 1.64e-17 Mean corpuscular volume; CESC cis rs826838 0.967 rs826879 chr12:39088999 A/C cg26384229 chr12:38710491 ALG10B -0.62 -10.22 -0.53 6.67e-21 Heart rate; CESC cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg05283184 chr6:79620031 NA -0.42 -6.43 -0.37 5.8e-10 Intelligence (multi-trait analysis); CESC trans rs801193 1.000 rs2420824 chr7:66131116 G/A cg26939375 chr7:64535504 NA -0.65 -8.64 -0.47 5.39e-16 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12458179 chr2:238969828 SCLY 0.56 6.73 0.38 1.06e-10 Gut microbiome composition (summer); CESC cis rs910316 0.737 rs398896 chr14:75482827 C/A cg16144293 chr14:75469539 EIF2B2 0.39 5.12 0.3 5.81e-7 Height; CESC cis rs6582630 0.502 rs2204008 chr12:38439203 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.66 0.33 3.84e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg06582575 chr6:163149167 PACRG;PARK2 1.02 10.2 0.53 7.92e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg05776053 chr2:74358815 NA 0.4 5.05 0.3 8.18e-7 Gestational age at birth (maternal effect); CESC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg13770153 chr20:60521292 NA -0.48 -6.17 -0.35 2.56e-9 Body mass index; CESC cis rs137699 0.687 rs4821887 chr22:39756985 C/T cg01416388 chr22:39784598 NA -0.53 -6.09 -0.35 3.86e-9 IgG glycosylation; CESC cis rs2236521 0.714 rs6062210 chr20:60890375 A/G cg12382846 chr20:60892121 LAMA5 0.38 7.03 0.4 1.8e-11 Pelvic organ prolapse; CESC cis rs12545109 0.800 rs1530217 chr8:57408097 C/T cg09654669 chr8:57350985 NA -0.56 -6.65 -0.38 1.67e-10 Obesity-related traits; CESC cis rs59698941 0.943 rs60545802 chr5:132204577 T/G cg02081065 chr5:132209139 LEAP2 -0.52 -5.12 -0.3 5.8e-7 Apolipoprotein A-IV levels; CESC cis rs34779708 0.966 rs34296409 chr10:35404613 C/G cg04310649 chr10:35416472 CREM -0.52 -6.25 -0.36 1.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs909341 0.710 rs6010998 chr20:62294402 A/T cg03999872 chr20:62272968 STMN3 0.55 5.38 0.31 1.66e-7 Atopic dermatitis; CESC cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg05090351 chr10:126851162 NA -0.6 -9.51 -0.5 1.23e-18 Menarche (age at onset); CESC cis rs4523957 0.786 rs9897624 chr17:2121745 A/G cg16513277 chr17:2031491 SMG6 -0.63 -8.77 -0.47 2.29e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11155671 0.530 rs9371215 chr6:150194298 C/T cg09699651 chr6:150184138 LRP11 0.52 6.95 0.39 2.88e-11 Testicular germ cell tumor; CESC cis rs9660992 0.573 rs7368327 chr1:205214792 C/T cg00857998 chr1:205179979 DSTYK 0.56 6.86 0.39 4.99e-11 Mean corpuscular volume;Mean platelet volume; CESC trans rs3780486 0.846 rs3824458 chr9:33144809 C/T cg04842962 chr6:43655489 MRPS18A 0.99 18.1 0.74 3.15e-48 IgG glycosylation; CESC cis rs7592578 0.771 rs4258824 chr2:191395027 C/T cg27211696 chr2:191398769 TMEM194B -0.57 -5.31 -0.31 2.37e-7 Diastolic blood pressure; CESC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4268898 0.662 rs17733015 chr2:24509370 A/G cg20701182 chr2:24300061 SF3B14 0.6 6.76 0.38 8.99e-11 Asthma; CESC cis rs11608355 0.552 rs2304549 chr12:109794875 A/G cg19025524 chr12:109796872 NA -0.54 -7.99 -0.44 4.03e-14 Neuroticism; CESC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg10691866 chr7:65817282 TPST1 0.32 5.53 0.32 7.79e-8 Aortic root size; CESC cis rs8092503 1.000 rs12957162 chr18:52484299 T/A cg12377874 chr18:52495404 RAB27B 0.41 6.49 0.37 4.22e-10 Childhood body mass index; CESC cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg22875332 chr1:76189707 ACADM 0.66 7.81 0.43 1.31e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 13.28 0.63 3.38e-31 Platelet count; CESC cis rs936229 0.861 rs7176022 chr15:75107880 G/T cg14664628 chr15:75095509 CSK 1.01 16.08 0.7 4.69e-41 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs4268898 0.560 rs2384007 chr2:24514841 A/G cg06627628 chr2:24431161 ITSN2 -0.9 -9.95 -0.52 5.1e-20 Asthma; CESC cis rs7089973 0.604 rs55759483 chr10:116573423 T/C cg03647239 chr10:116582469 FAM160B1 0.42 5.39 0.31 1.59e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6121246 0.512 rs6058384 chr20:30276409 A/T cg13852791 chr20:30311386 BCL2L1 0.81 10.51 0.54 8.04e-22 Mean corpuscular hemoglobin; CESC cis rs1499614 1.000 rs2659913 chr7:66157336 T/A cg13147721 chr7:65941812 NA -0.94 -8.9 -0.48 9.08e-17 Gout; CESC cis rs5769765 0.908 rs9627788 chr22:50300438 T/C cg26441486 chr22:50317300 CRELD2 0.39 5.45 0.32 1.13e-7 Schizophrenia; CESC cis rs240764 0.764 rs6910391 chr6:100925774 T/C cg21058520 chr6:100914733 NA 0.37 5.76 0.33 2.34e-8 Neuroticism; CESC cis rs10089 1.000 rs77086350 chr5:127494431 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.43 0.5 2.17e-18 Ileal carcinoids; CESC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg27022615 chr11:70049105 FADD -0.51 -6.59 -0.38 2.42e-10 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs8073060 0.586 rs225305 chr17:33921160 C/T cg19694781 chr19:47549865 TMEM160 -0.7 -6.84 -0.39 5.46e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs1801251 0.963 rs6739638 chr2:233576015 G/A cg08000102 chr2:233561755 GIGYF2 0.68 9.27 0.49 6.98e-18 Coronary artery disease; CESC cis rs1499614 0.803 rs1796229 chr7:66119661 G/A cg13147721 chr7:65941812 NA -0.93 -8.6 -0.47 7.11e-16 Gout; CESC cis rs4974559 0.501 rs1250096 chr4:1238836 G/C cg02980000 chr4:1222292 CTBP1 -0.77 -7.95 -0.44 5.45e-14 Systolic blood pressure; CESC cis rs7296418 0.663 rs4553407 chr12:123750748 G/C cg05973401 chr12:123451056 ABCB9 0.46 5.93 0.34 9.46e-9 Platelet count; CESC cis rs400736 0.628 rs12758337 chr1:8145294 C/T cg25007680 chr1:8021821 PARK7 -0.65 -8.88 -0.48 1.01e-16 Response to antidepressants and depression; CESC cis rs2282802 0.685 rs7715538 chr5:139665181 T/C cg26211634 chr5:139558579 C5orf32 0.51 7.42 0.41 1.55e-12 Intelligence (multi-trait analysis); CESC cis rs10097731 0.901 rs10464931 chr8:82042664 A/G cg25230327 chr8:82042993 NA 0.52 5.71 0.33 2.95e-8 Serum total protein level; CESC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg24531977 chr5:56204891 C5orf35 -0.42 -5.33 -0.31 2.1e-7 Coronary artery disease; CESC cis rs12597458 0.752 rs8051239 chr16:72036257 T/A cg01557791 chr16:72042693 DHODH 0.82 12.63 0.61 6.2e-29 Prostate cancer; CESC cis rs2439831 0.850 rs28564774 chr15:44125475 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.43 0.42 1.45e-12 Lung cancer in ever smokers; CESC cis rs6922893 1.000 rs1320315 chr6:71666146 T/C cg10766373 chr6:71666121 B3GAT2 -0.34 -5.36 -0.31 1.78e-7 Obesity-related traits; CESC cis rs425277 0.958 rs262639 chr1:2107061 G/T cg04315214 chr1:2043799 PRKCZ -0.38 -5.34 -0.31 1.96e-7 Height; CESC cis rs10791097 0.690 rs12284487 chr11:130729705 T/C cg12179176 chr11:130786555 SNX19 0.58 8.5 0.46 1.41e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7799006 0.757 rs2398668 chr7:2298227 A/G cg12745145 chr7:2261452 MAD1L1 0.33 5.45 0.32 1.17e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9303401 0.703 rs8077052 chr17:57208921 T/G cg10487724 chr17:56770010 TEX14;RAD51C 0.68 8.6 0.47 7e-16 Cognitive test performance; CESC cis rs644799 0.710 rs10831429 chr11:95508524 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.75 11.15 0.57 6.35e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs5769765 0.913 rs2319462 chr22:50263370 C/T cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg07936489 chr17:37558343 FBXL20 -0.78 -10.96 -0.56 2.63e-23 Glomerular filtration rate (creatinine); CESC cis rs6598955 0.671 rs11247908 chr1:26638222 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.39 5.38 0.31 1.62e-7 Obesity-related traits; CESC cis rs763121 0.853 rs4820345 chr22:39091151 T/C cg14440974 chr22:39074834 NA -0.43 -5.71 -0.33 2.98e-8 Menopause (age at onset); CESC cis rs7917772 0.619 rs2801050 chr10:104509393 T/A cg04362960 chr10:104952993 NT5C2 -0.48 -5.45 -0.32 1.16e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg13628971 chr7:2884303 GNA12 0.58 7.31 0.41 3.23e-12 Height; CESC cis rs36051895 0.589 rs16922772 chr9:5194521 C/A cg02405213 chr9:5042618 JAK2 -0.53 -6.15 -0.35 2.82e-9 Pediatric autoimmune diseases; CESC cis rs71277158 0.688 rs7638400 chr3:169837787 A/G cg04067573 chr3:169899625 PHC3 0.71 7.06 0.4 1.45e-11 Prostate cancer; CESC cis rs2425143 0.915 rs2378408 chr20:34367732 T/C cg04508476 chr20:34239394 CPNE1;RBM12 0.8 7.75 0.43 1.96e-13 Blood protein levels; CESC cis rs7208859 0.573 rs8070182 chr17:29135594 A/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.52 0.37 3.61e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7727544 0.716 rs6863213 chr5:131575932 C/T cg14196790 chr5:131705035 SLC22A5 0.36 5.28 0.31 2.64e-7 Blood metabolite levels; CESC cis rs1163251 0.837 rs658442 chr1:120244858 T/G cg19096424 chr1:120255104 PHGDH 0.52 6.67 0.38 1.52e-10 Blood metabolite levels; CESC cis rs709400 0.567 rs1961600 chr14:103862144 G/A cg12935359 chr14:103987150 CKB -0.52 -7.62 -0.42 4.4e-13 Body mass index; CESC cis rs9925964 0.622 rs8046707 chr16:30916233 G/A cg02466173 chr16:30829666 NA 0.36 5.43 0.32 1.26e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs3105593 0.563 rs539383 chr15:50878478 C/T cg08437265 chr15:50716283 USP8 0.42 5.33 0.31 2.09e-7 QT interval; CESC cis rs9287719 0.967 rs6432126 chr2:10757101 A/G cg00105475 chr2:10696890 NA 0.37 5.4 0.31 1.52e-7 Prostate cancer; CESC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg07167872 chr1:205819463 PM20D1 0.77 12.43 0.61 3.03e-28 Menarche (age at onset); CESC cis rs10129255 0.518 rs8009594 chr14:107185733 G/T cg07958169 chr14:107095056 NA -0.55 -8.62 -0.47 6.1e-16 Kawasaki disease; CESC cis rs17376456 0.825 rs35426871 chr5:93291613 C/T cg21475434 chr5:93447410 FAM172A 0.74 6.26 0.36 1.54e-9 Diabetic retinopathy; CESC cis rs3105593 1.000 rs3109892 chr15:50877011 A/T cg08437265 chr15:50716283 USP8 0.39 5.1 0.3 6.41e-7 QT interval; CESC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg20999797 chr1:1681921 NA 0.27 5.21 0.31 3.71e-7 Body mass index; CESC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg18446336 chr7:2847575 GNA12 0.34 5.31 0.31 2.34e-7 Height; CESC cis rs2276314 1.000 rs4573997 chr18:33552568 C/T cg05985134 chr18:33552581 C18orf21 0.67 7.86 0.44 9.41e-14 Endometriosis;Drug-induced torsades de pointes; CESC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg04518342 chr5:131593106 PDLIM4 -0.36 -5.25 -0.31 3.13e-7 Breast cancer; CESC cis rs36051895 0.632 rs12343038 chr9:5178579 A/G cg02405213 chr9:5042618 JAK2 0.51 6.55 0.37 2.98e-10 Pediatric autoimmune diseases; CESC cis rs73206853 0.841 rs57299791 chr12:110954021 G/A cg12870014 chr12:110450643 ANKRD13A 0.63 5.22 0.31 3.56e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg04369109 chr6:150039330 LATS1 -0.38 -5.2 -0.3 4.06e-7 Lung cancer; CESC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg17971929 chr21:40555470 PSMG1 1.08 16.28 0.71 9.03e-42 Cognitive function; CESC cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.88 11.34 0.57 1.46e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.46 -5.28 -0.31 2.65e-7 Breast cancer; CESC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs7264396 0.790 rs6058288 chr20:34228680 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.6 -7.4 -0.41 1.84e-12 Total cholesterol levels; CESC cis rs9650657 0.529 rs10108618 chr8:10953092 A/G cg21775007 chr8:11205619 TDH -0.38 -5.52 -0.32 8.13e-8 Neuroticism; CESC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg25427524 chr10:38739819 LOC399744 -0.71 -10.63 -0.55 3.34e-22 Extrinsic epigenetic age acceleration; CESC cis rs919433 0.783 rs2565165 chr2:198233575 T/G cg03934865 chr2:198174659 NA 0.43 6.21 0.36 2.01e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg06481639 chr22:41940642 POLR3H 0.52 5.58 0.32 5.84e-8 Vitiligo; CESC cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg00033643 chr7:134001901 SLC35B4 0.43 5.61 0.33 5.13e-8 Mean platelet volume; CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg16145915 chr7:1198662 ZFAND2A -0.7 -11.1 -0.56 8.95e-24 Longevity;Endometriosis; CESC cis rs722599 0.715 rs61978928 chr14:75321714 T/C cg11812906 chr14:75593930 NEK9 -0.46 -5.63 -0.33 4.49e-8 IgG glycosylation; CESC cis rs10504073 0.506 rs7007271 chr8:49941897 T/C cg00325661 chr8:49890786 NA 0.56 8.42 0.46 2.33e-15 Blood metabolite ratios; CESC cis rs4242434 0.787 rs1545837 chr8:22477807 T/C cg03733263 chr8:22462867 KIAA1967 0.77 10.0 0.52 3.44e-20 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs7618501 0.815 rs3819325 chr3:49843723 T/C cg24308560 chr3:49941425 MST1R -0.53 -7.12 -0.4 1.04e-11 Intelligence (multi-trait analysis); CESC cis rs7116495 0.786 rs4479013 chr11:71673732 C/G cg10381502 chr11:71823885 C11orf51 -0.68 -5.67 -0.33 3.64e-8 Severe influenza A (H1N1) infection; CESC cis rs4595586 0.525 rs11613788 chr12:39390710 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs524281 0.861 rs11227426 chr11:65971951 T/C cg14036092 chr11:66035641 RAB1B -0.49 -5.29 -0.31 2.56e-7 Electroencephalogram traits; CESC cis rs561341 0.941 rs8066156 chr17:30361629 A/G cg19193384 chr17:30244184 NA -0.52 -5.63 -0.33 4.55e-8 Hip circumference adjusted for BMI; CESC cis rs2075371 0.830 rs1421478 chr7:133922793 T/A cg11752832 chr7:134001865 SLC35B4 0.53 6.89 0.39 4.15e-11 Mean platelet volume; CESC cis rs412050 0.547 rs5999842 chr22:22214889 G/A cg17089214 chr22:22089827 YPEL1 0.75 6.3 0.36 1.22e-9 Attention deficit hyperactivity disorder; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00145979 chr1:155057785 EFNA3 -0.44 -6.12 -0.35 3.28e-9 Gambling; CESC cis rs710216 0.718 rs841852 chr1:43401499 C/T cg03128534 chr1:43423976 SLC2A1 0.44 5.13 0.3 5.62e-7 Red cell distribution width; CESC cis rs7223966 1.000 rs992416 chr17:61745905 A/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.16 -0.3 4.73e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs3106136 0.934 rs2902979 chr4:95177874 C/G cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.72 -0.38 1.14e-10 Capecitabine sensitivity; CESC cis rs1371867 0.846 rs2439460 chr8:101312665 C/T cg11906718 chr8:101322791 RNF19A 0.46 5.92 0.34 1.02e-8 Atrioventricular conduction; CESC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg04169830 chr2:88471460 THNSL2 0.33 5.13 0.3 5.56e-7 Response to metformin (IC50); CESC cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.31e-15 Colonoscopy-negative controls vs population controls; CESC trans rs7615952 0.515 rs4441610 chr3:125681307 C/G cg07211511 chr3:129823064 LOC729375 -0.64 -6.94 -0.39 3.1e-11 Blood pressure (smoking interaction); CESC cis rs3820068 0.705 rs6656907 chr1:15896984 A/G cg18192808 chr1:15853278 DNAJC16 0.43 5.13 0.3 5.68e-7 Systolic blood pressure; CESC trans rs1814175 0.904 rs7924371 chr11:49620595 C/T cg03929089 chr4:120376271 NA -0.87 -13.32 -0.63 2.44e-31 Height; CESC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg07677032 chr17:61819896 STRADA 0.44 5.88 0.34 1.23e-8 Prudent dietary pattern; CESC cis rs2204008 0.840 rs7136347 chr12:38453531 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.64 0.55 3.12e-22 Bladder cancer; CESC trans rs9578106 0.703 rs76717881 chr13:30155738 G/A cg08144675 chr16:73097057 NA -0.58 -6.05 -0.35 4.81e-9 Breast cancer; CESC cis rs61931739 0.658 rs4476006 chr12:34237154 A/C cg19457237 chr12:34500585 NA -0.38 -5.45 -0.32 1.15e-7 Morning vs. evening chronotype; CESC cis rs3857536 0.544 rs208453 chr6:66906841 A/T cg07460842 chr6:66804631 NA -0.65 -8.0 -0.44 3.79e-14 Blood trace element (Cu levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18783047 chr19:10420351 ZGLP1 -0.58 -6.35 -0.36 9.35e-10 Gut microbiome composition (summer); CESC cis rs2637266 0.655 rs861744 chr10:78519132 T/G cg18941641 chr10:78392320 NA 0.41 7.76 0.43 1.89e-13 Pulmonary function; CESC cis rs1030268 0.608 rs12707106 chr7:133311350 A/T cg10665199 chr7:133106180 EXOC4 0.51 5.38 0.31 1.6e-7 Intelligence (multi-trait analysis); CESC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg02951883 chr7:2050386 MAD1L1 0.49 6.34 0.36 9.96e-10 Bipolar disorder and schizophrenia; CESC cis rs57506017 0.585 rs10234805 chr7:12253543 T/C cg23422036 chr7:12250390 TMEM106B 0.39 5.21 0.3 3.76e-7 Neuroticism; CESC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.71 0.38 1.17e-10 Bipolar disorder; CESC cis rs57506017 0.585 rs28549831 chr7:12268117 C/T cg23422036 chr7:12250390 TMEM106B 0.38 5.13 0.3 5.58e-7 Neuroticism; CESC trans rs3942852 0.806 rs4752807 chr11:48128751 T/G cg03929089 chr4:120376271 NA -0.56 -6.34 -0.36 1.01e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs17376456 0.825 rs12153021 chr5:93073913 A/G cg25358565 chr5:93447407 FAM172A 1.1 10.54 0.54 6.5e-22 Diabetic retinopathy; CESC cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg00409905 chr10:38381863 ZNF37A -0.45 -5.96 -0.34 7.89e-9 Extrinsic epigenetic age acceleration; CESC cis rs992157 0.835 rs2045434 chr2:219144498 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.67 -8.69 -0.47 3.72e-16 Colorectal cancer; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg01238044 chr22:24384105 GSTT1 -0.66 -8.63 -0.47 5.75e-16 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs875971 0.666 rs13242072 chr7:65765988 A/G cg26939375 chr7:64535504 NA -0.64 -8.48 -0.46 1.64e-15 Aortic root size; CESC cis rs8092503 1.000 rs3764515 chr18:52494397 G/T cg12377874 chr18:52495404 RAB27B 0.37 6.14 0.35 3.02e-9 Childhood body mass index; CESC cis rs6831352 0.918 rs13107558 chr4:100050200 C/A cg13256891 chr4:100009986 ADH5 -0.75 -8.6 -0.47 7.31e-16 Alcohol dependence; CESC cis rs5769765 0.908 rs138891 chr22:50227741 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.47 -5.26 -0.31 3e-7 Schizophrenia; CESC cis rs9393777 0.623 rs7773938 chr6:26474044 C/T cg14345882 chr6:26364793 BTN3A2 0.44 5.36 0.31 1.81e-7 Intelligence (multi-trait analysis); CESC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.83 8.4 0.46 2.81e-15 Platelet count; CESC cis rs1865721 0.771 rs8093397 chr18:73136217 C/G cg26385618 chr18:73139727 C18orf62 -0.51 -8.36 -0.46 3.47e-15 Intelligence; CESC cis rs17125944 0.556 rs12588482 chr14:53311552 G/A cg00686598 chr14:53173677 PSMC6 -0.67 -5.84 -0.34 1.52e-8 Alzheimer's disease (late onset); CESC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.3 0.36 1.24e-9 Menopause (age at onset); CESC cis rs12912251 1.000 rs71403553 chr15:38989121 C/A cg01338139 chr15:38987640 C15orf53 -0.47 -5.43 -0.32 1.26e-7 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CESC cis rs2932538 0.922 rs61818800 chr1:113148571 A/G cg22162597 chr1:113214053 CAPZA1 0.57 7.39 0.41 1.92e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.57 7.33 0.41 2.84e-12 Tonsillectomy; CESC cis rs6558174 1.000 rs6558174 chr8:22492129 A/G cg03733263 chr8:22462867 KIAA1967 0.5 6.19 0.36 2.3e-9 Breast cancer; CESC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg06636001 chr8:8085503 FLJ10661 -0.43 -5.62 -0.33 4.8e-8 Mood instability; CESC cis rs763121 0.853 rs5757200 chr22:39043491 T/G cg06022373 chr22:39101656 GTPBP1 0.88 13.79 0.65 5.43e-33 Menopause (age at onset); CESC trans rs1003719 0.715 rs762139 chr21:38568475 A/T cg23660064 chr1:223395288 SUSD4 0.43 6.05 0.35 4.89e-9 Eye color traits; CESC cis rs2637266 0.905 rs10824428 chr10:78346041 G/A cg18941641 chr10:78392320 NA 0.4 7.38 0.41 1.98e-12 Pulmonary function; CESC cis rs3096299 0.900 rs4785666 chr16:89462771 C/G cg08822215 chr16:89438651 ANKRD11 -0.43 -6.77 -0.38 8.06e-11 Multiple myeloma (IgH translocation); CESC cis rs765787 0.530 rs2413776 chr15:45544170 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.37 -0.41 2.19e-12 Uric acid levels; CESC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg18904891 chr8:8559673 CLDN23 0.7 7.89 0.44 7.96e-14 Obesity-related traits; CESC cis rs6089584 1.000 rs6089583 chr20:60563624 G/A cg06108461 chr20:60628389 TAF4 -0.78 -11.24 -0.57 3.19e-24 Body mass index; CESC cis rs4835473 0.900 rs35419968 chr4:144655736 G/A cg25736465 chr4:144833511 NA -0.33 -5.23 -0.31 3.44e-7 Immature fraction of reticulocytes; CESC cis rs2637266 0.783 rs846627 chr10:78539556 A/G cg18941641 chr10:78392320 NA 0.42 8.44 0.46 2.13e-15 Pulmonary function; CESC cis rs2463822 0.920 rs28678254 chr11:62151875 G/C cg06239285 chr11:62104954 ASRGL1 -0.98 -8.69 -0.47 3.86e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs80282103 0.867 rs74117668 chr10:1076620 C/T cg08668510 chr10:1095578 IDI1 0.66 5.24 0.31 3.24e-7 Glomerular filtration rate (creatinine); CESC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05048922 chr8:6565434 AGPAT5 -0.45 -6.27 -0.36 1.45e-9 Gambling; CESC cis rs870825 0.549 rs10015956 chr4:185614705 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs3733585 0.699 rs62294331 chr4:9959889 A/G cg02734326 chr4:10020555 SLC2A9 -0.43 -6.01 -0.35 6.1e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13191362 0.507 rs2846536 chr6:163033492 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.51 6.4 0.37 6.98e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs887829 0.569 rs6711351 chr2:234634916 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.54 -7.44 -0.42 1.4e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs6732160 0.588 rs1430345 chr2:73370682 A/G cg01422370 chr2:73384389 NA 0.52 8.36 0.46 3.58e-15 Intelligence (multi-trait analysis); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg18876457 chr1:160071037 NA -0.46 -7.15 -0.4 8.69e-12 Vertical cup-disc ratio; CESC cis rs4689388 0.679 rs1046316 chr4:6304087 A/G cg14416269 chr4:6271139 WFS1 0.44 6.65 0.38 1.64e-10 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg13101948 chr6:4056654 PRPF4B 0.47 6.24 0.36 1.68e-9 Thyroid stimulating hormone; CESC cis rs2425143 1.000 rs111597121 chr20:34371913 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.69 5.95 0.34 8.54e-9 Blood protein levels; CESC cis rs7833790 0.929 rs10958048 chr8:82792914 C/T cg07697082 chr8:82753677 SNX16 -0.39 -5.4 -0.31 1.47e-7 Diastolic blood pressure; CESC cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.83 0.34 1.62e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2120019 1.000 rs12185102 chr15:75352201 G/A cg09165964 chr15:75287851 SCAMP5 -0.73 -8.56 -0.47 9.11e-16 Blood trace element (Zn levels); CESC cis rs2479724 0.811 rs6905726 chr6:41750812 T/C cg08135965 chr6:41755394 TOMM6 -0.41 -5.28 -0.31 2.72e-7 Menarche (age at onset); CESC cis rs524281 0.817 rs10896092 chr11:65958046 A/C cg14036092 chr11:66035641 RAB1B -0.5 -5.48 -0.32 1.01e-7 Electroencephalogram traits; CESC cis rs3820928 0.934 rs4675117 chr2:227769794 A/G cg11843606 chr2:227700838 RHBDD1 0.43 5.36 0.31 1.84e-7 Pulmonary function; CESC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg11644478 chr21:40555479 PSMG1 -0.82 -12.36 -0.6 5.25e-28 Cognitive function; CESC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg13770153 chr20:60521292 NA -0.47 -6.07 -0.35 4.44e-9 Body mass index; CESC cis rs4253772 0.938 rs78336060 chr22:46641597 C/T cg00784671 chr22:46762841 CELSR1 -0.57 -5.62 -0.33 4.95e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg03647317 chr4:187891568 NA -0.39 -5.83 -0.34 1.57e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs9815354 0.638 rs12634670 chr3:41875299 G/C cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.84e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs668210 0.793 rs506873 chr11:65767215 A/C cg02202077 chr11:65769826 EIF1AD;BANF1 -0.71 -7.77 -0.43 1.78e-13 Cerebrospinal fluid biomarker levels; CESC trans rs7741085 1.000 rs7741085 chr6:44636919 C/T cg04735960 chr13:21006388 CRYL1 -0.47 -6.37 -0.36 8.55e-10 Total body bone mineral density; CESC cis rs1728785 0.901 rs11075688 chr16:68655924 A/G cg02972257 chr16:68554789 NA 0.68 7.46 0.42 1.25e-12 Ulcerative colitis; CESC cis rs17376456 0.825 rs13164315 chr5:93147421 A/G cg25358565 chr5:93447407 FAM172A 1.11 10.65 0.55 2.72e-22 Diabetic retinopathy; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg05013783 chr12:56652058 ANKRD52 0.46 6.31 0.36 1.14e-9 Systemic lupus erythematosus; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21255605 chr3:14989131 NR2C2 -0.52 -7.03 -0.4 1.7e-11 Gut microbiota (bacterial taxa); CESC cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg12386194 chr3:101231763 SENP7 0.44 5.48 0.32 9.88e-8 Colorectal cancer; CESC cis rs12893668 0.637 rs4525427 chr14:104072793 C/A cg24130564 chr14:104152367 KLC1 -0.51 -6.4 -0.37 7.05e-10 Reticulocyte count; CESC cis rs6545883 0.929 rs7563678 chr2:61741811 C/T cg15711740 chr2:61764176 XPO1 0.42 5.19 0.3 4.24e-7 Tuberculosis; CESC cis rs4835473 0.932 rs1849120 chr4:144906490 A/T cg25736465 chr4:144833511 NA 0.41 6.29 0.36 1.28e-9 Immature fraction of reticulocytes; CESC cis rs2832077 0.527 rs2738953 chr21:30238363 G/C cg03476357 chr21:30257390 N6AMT1 0.46 5.87 0.34 1.27e-8 Cognitive test performance; CESC cis rs9611565 0.681 rs5751094 chr22:41803279 C/T cg06634786 chr22:41940651 POLR3H 0.71 7.47 0.42 1.16e-12 Vitiligo; CESC cis rs34375054 0.526 rs7302475 chr12:125677886 T/C cg00522288 chr12:125625016 AACS -0.34 -5.21 -0.3 3.84e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg25767906 chr1:53392781 SCP2 -0.5 -7.01 -0.4 1.92e-11 Monocyte count; CESC cis rs2243480 0.831 rs57294491 chr7:65684901 T/A cg13147721 chr7:65941812 NA 0.98 9.23 0.49 9.21e-18 Diabetic kidney disease; CESC cis rs6912958 0.712 rs6454641 chr6:88371060 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.35 -5.68 -0.33 3.46e-8 Monocyte percentage of white cells; CESC cis rs703842 1.000 rs3825079 chr12:58203354 C/T cg00677455 chr12:58241039 CTDSP2 0.52 6.7 0.38 1.23e-10 Multiple sclerosis; CESC cis rs4727963 0.511 rs846655 chr7:122645560 A/G cg03640110 chr7:122635026 TAS2R16 -0.52 -8.23 -0.45 8.33e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CESC cis rs2637266 0.783 rs2588334 chr10:78518504 C/T cg18941641 chr10:78392320 NA 0.38 7.4 0.41 1.84e-12 Pulmonary function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16594066 chr16:30569726 ZNF764 -0.42 -6.1 -0.35 3.82e-9 Fibrinogen levels; CESC cis rs7267979 0.934 rs4815423 chr20:25387521 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -16.38 -0.71 3.84e-42 Liver enzyme levels (alkaline phosphatase); CESC trans rs35110281 0.807 rs1598206 chr21:45058776 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 6.85 0.39 5.3e-11 Mean corpuscular volume; CESC cis rs2228479 0.717 rs12917681 chr16:89810941 C/A cg04287289 chr16:89883240 FANCA 0.71 6.55 0.37 3.01e-10 Skin colour saturation; CESC cis rs6987853 0.933 rs6474401 chr8:42367068 T/C cg09913449 chr8:42400586 C8orf40 -0.42 -6.72 -0.38 1.1e-10 Mean corpuscular hemoglobin concentration; CESC cis rs1904096 0.506 rs28522293 chr4:95167087 A/G cg11021082 chr4:95130006 SMARCAD1 -0.63 -10.06 -0.53 2.19e-20 Type 2 diabetes; CESC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.58 0.81 1.09e-63 Prudent dietary pattern; CESC cis rs6582630 0.548 rs1607870 chr12:38385964 G/T cg26384229 chr12:38710491 ALG10B -0.47 -6.27 -0.36 1.45e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7264396 0.563 rs2425146 chr20:34355268 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -10.2 -0.53 7.89e-21 Total cholesterol levels; CESC cis rs763121 0.853 rs1569716 chr22:38998519 C/A cg06544989 chr22:39130855 UNC84B 0.49 8.97 0.48 5.72e-17 Menopause (age at onset); CESC cis rs9815354 0.812 rs73077386 chr3:41857652 A/G cg03022575 chr3:42003672 ULK4 0.7 6.34 0.36 1.01e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs2070488 0.775 rs13098946 chr3:38517784 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 13.23 0.63 5.09e-31 Electrocardiographic conduction measures; CESC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.62 8.39 0.46 2.99e-15 Menopause (age at onset); CESC cis rs12458462 0.859 rs35493271 chr18:77448793 G/T cg23301140 chr18:77439876 CTDP1 0.57 7.7 0.43 2.65e-13 Monocyte count; CESC cis rs4964805 0.657 rs11111787 chr12:104189499 C/T cg02344784 chr12:104178138 NT5DC3 0.46 6.57 0.37 2.73e-10 Attention deficit hyperactivity disorder; CESC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg24829409 chr8:58192753 C8orf71 -0.74 -9.68 -0.51 3.6e-19 Developmental language disorder (linguistic errors); CESC cis rs8141529 0.702 rs469990 chr22:29304200 A/T cg15103426 chr22:29168792 CCDC117 0.62 8.1 0.45 2.05e-14 Lymphocyte counts; CESC cis rs870825 0.581 rs28602720 chr4:185630598 T/C cg04058563 chr4:185651563 MLF1IP 0.64 7.0 0.4 2.05e-11 Blood protein levels; CESC cis rs798766 1.000 rs3099555 chr4:1725651 T/C cg05874882 chr4:1763078 NA -0.61 -8.56 -0.47 9.25e-16 Bladder cancer;Urinary bladder cancer; CESC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg18099408 chr3:52552593 STAB1 -0.31 -5.31 -0.31 2.3e-7 Electroencephalogram traits; CESC cis rs9611565 0.659 rs9611604 chr22:41916001 C/G cg03806693 chr22:41940476 POLR3H -1.22 -15.34 -0.69 1.99e-38 Vitiligo; CESC cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17484976 chr20:60982411 CABLES2 0.56 6.83 0.39 5.86e-11 Gut microbiome composition (summer); CESC cis rs9660180 0.839 rs12040826 chr1:1705287 A/C cg03396347 chr1:1875803 NA -0.41 -6.34 -0.36 1.01e-9 Body mass index; CESC cis rs2274273 0.870 rs10142547 chr14:55763963 T/C cg04306507 chr14:55594613 LGALS3 0.31 6.09 0.35 4.01e-9 Protein biomarker; CESC cis rs34779708 0.741 rs34397613 chr10:35550313 A/G cg03585969 chr10:35415529 CREM 0.54 6.12 0.35 3.34e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs4835473 0.932 rs12512649 chr4:144657898 A/G cg25736465 chr4:144833511 NA -0.33 -5.23 -0.31 3.4e-7 Immature fraction of reticulocytes; CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg05564831 chr3:52568323 NT5DC2 0.49 8.27 0.45 6.76e-15 Electroencephalogram traits; CESC cis rs8141529 0.778 rs763073 chr22:29215542 G/A cg15103426 chr22:29168792 CCDC117 0.67 9.75 0.51 2.24e-19 Lymphocyte counts; CESC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg16325326 chr1:53192061 ZYG11B 0.89 15.1 0.68 1.38e-37 Monocyte count; CESC cis rs12079745 0.623 rs12091844 chr1:169433273 C/T cg09363564 chr1:169337483 NME7;BLZF1 -1.16 -6.88 -0.39 4.39e-11 QT interval; CESC cis rs57244997 0.582 rs73030432 chr6:162439864 G/A cg17173639 chr6:162384350 PARK2 -0.45 -5.19 -0.3 4.15e-7 Mosquito bite size; CESC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 11.96 0.59 1.2e-26 Alzheimer's disease; CESC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg06453172 chr10:134556979 INPP5A -0.42 -5.51 -0.32 8.32e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs7020830 0.898 rs2790063 chr9:37287405 G/A cg14294708 chr9:37120828 ZCCHC7 1.11 20.53 0.78 1.06e-56 Schizophrenia; CESC cis rs698813 0.642 rs1837702 chr2:44492444 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.49 5.43 0.32 1.3e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs2404602 0.692 rs2120108 chr15:76869929 G/T cg26408565 chr15:76604113 ETFA 0.37 5.38 0.31 1.62e-7 Blood metabolite levels; CESC cis rs1153858 1.000 rs2453541 chr15:45645378 G/A cg21132104 chr15:45694354 SPATA5L1 0.76 10.17 0.53 1.03e-20 Homoarginine levels; CESC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.94 -0.52 5.53e-20 Developmental language disorder (linguistic errors); CESC cis rs472402 0.580 rs3733773 chr5:6652252 G/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.55 -7.06 -0.4 1.43e-11 Response to amphetamines; CESC cis rs67311347 1.000 rs7631893 chr3:40440869 C/T cg09455208 chr3:40491958 NA 0.45 8.07 0.44 2.44e-14 Renal cell carcinoma; CESC cis rs7647973 0.626 rs4855845 chr3:49687043 T/C cg03060546 chr3:49711283 APEH 0.68 8.35 0.46 3.86e-15 Menarche (age at onset); CESC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.62 7.55 0.42 6.95e-13 Age-related macular degeneration (geographic atrophy); CESC cis rs12145833 0.596 rs10737887 chr1:243424146 T/C cg02356786 chr1:243265016 LOC731275 -0.6 -5.18 -0.3 4.3e-7 Obesity (early onset extreme); CESC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg01416388 chr22:39784598 NA -0.6 -7.51 -0.42 9.01e-13 Intelligence (multi-trait analysis); CESC cis rs6060717 0.653 rs2590962 chr20:34615363 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.49 6.23 0.36 1.86e-9 Hip circumference adjusted for BMI; CESC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg03396347 chr1:1875803 NA -0.42 -6.63 -0.38 1.82e-10 Body mass index; CESC cis rs8114671 0.562 rs6087642 chr20:33468306 T/C cg06115741 chr20:33292138 TP53INP2 0.43 5.28 0.31 2.72e-7 Height; CESC cis rs6831352 1.000 rs6837685 chr4:100049145 G/A cg12011299 chr4:100065546 ADH4 0.69 8.43 0.46 2.17e-15 Alcohol dependence; CESC cis rs9457247 1.000 rs439553 chr6:167391212 A/G cg07741184 chr6:167504864 NA 0.33 5.98 0.34 7.1e-9 Crohn's disease; CESC cis rs12477438 0.765 rs6740054 chr2:99576631 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.76 -0.47 2.41e-16 Chronic sinus infection; CESC trans rs7246760 0.867 rs16981648 chr19:9804424 A/C cg02900749 chr2:68251473 NA -0.82 -7.19 -0.4 6.54e-12 Pursuit maintenance gain; CESC cis rs698813 0.604 rs1596010 chr2:44491804 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 5.68 0.33 3.49e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs9911578 1.000 rs12938772 chr17:56776320 T/C cg12560992 chr17:57184187 TRIM37 0.9 15.1 0.68 1.36e-37 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06331185 chr16:23689892 PLK1 0.57 6.57 0.37 2.7e-10 Gut microbiome composition (summer); CESC cis rs10858096 0.608 rs413582 chr1:109851126 C/T cg08367326 chr1:110052010 AMIGO1 0.42 5.14 0.3 5.26e-7 Intelligence (multi-trait analysis); CESC cis rs9911578 1.000 rs9911578 chr17:56953147 C/T cg12560992 chr17:57184187 TRIM37 0.94 15.65 0.69 1.5e-39 Intelligence (multi-trait analysis); CESC cis rs4253772 0.872 rs45552534 chr22:46638171 G/A cg00784671 chr22:46762841 CELSR1 -0.51 -5.27 -0.31 2.87e-7 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18444519 chr5:134210458 TXNDC15 0.49 6.2 0.36 2.18e-9 Gut microbiome composition (summer); CESC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg26335602 chr6:28129616 ZNF389 0.53 6.74 0.38 9.91e-11 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09378105 chr7:100895380 NA 0.61 7.17 0.4 7.46e-12 Gut microbiome composition (summer); CESC cis rs4268898 0.662 rs17733015 chr2:24509370 A/G cg06627628 chr2:24431161 ITSN2 -0.96 -11.37 -0.57 1.15e-24 Asthma; CESC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg02269571 chr22:50332266 NA -0.55 -6.8 -0.39 6.73e-11 Schizophrenia; CESC cis rs10791097 0.765 rs4622274 chr11:130729486 C/T cg12179176 chr11:130786555 SNX19 0.57 8.25 0.45 7.65e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9916302 0.904 rs4794814 chr17:37696852 G/A cg00129232 chr17:37814104 STARD3 -0.57 -7.53 -0.42 7.83e-13 Glomerular filtration rate (creatinine); CESC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg18876405 chr7:65276391 NA -0.59 -7.97 -0.44 4.6e-14 Aortic root size; CESC cis rs6500395 1.000 rs8052196 chr16:48691644 C/T cg04672837 chr16:48644449 N4BP1 -0.51 -6.36 -0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs34375054 0.526 rs7302475 chr12:125677886 T/C cg05341575 chr12:125625032 AACS -0.37 -5.27 -0.31 2.81e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs854765 0.686 rs8065497 chr17:17782649 A/G cg04398451 chr17:18023971 MYO15A 0.62 8.32 0.45 4.84e-15 Total body bone mineral density; CESC cis rs9916302 0.706 rs8182252 chr17:37727950 T/C cg07936489 chr17:37558343 FBXL20 0.94 12.28 0.6 9.67e-28 Glomerular filtration rate (creatinine); CESC cis rs11098499 0.645 rs72676059 chr4:120290828 C/G cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs6740322 0.895 rs13384080 chr2:43557363 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -7.44 -0.42 1.45e-12 Coronary artery disease; CESC cis rs9929218 0.954 rs12928043 chr16:68828885 G/A cg02972257 chr16:68554789 NA 0.45 5.37 0.31 1.74e-7 Colorectal cancer; CESC cis rs11785400 1.000 rs4736342 chr8:143735190 A/G cg24634471 chr8:143751801 JRK 0.47 6.02 0.35 5.81e-9 Schizophrenia; CESC cis rs722599 0.683 rs17102847 chr14:75324780 A/G cg08847533 chr14:75593920 NEK9 -0.48 -5.97 -0.34 7.73e-9 IgG glycosylation; CESC trans rs1814175 0.817 rs4084376 chr11:49831160 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -20.7 -0.79 2.81e-57 Height; CESC cis rs16857609 0.600 rs10932715 chr2:218259783 A/G cg15335768 chr2:218268053 DIRC3 -0.37 -5.8 -0.34 1.92e-8 Breast cancer;Breast cancer (estrogen-receptor negative); CESC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg13556452 chr1:2391241 NA -0.35 -6.13 -0.35 3.09e-9 Schizophrenia; CESC trans rs7839040 0.698 rs7836498 chr8:82928782 A/G cg14472086 chr9:107730925 NA -0.47 -6.33 -0.36 1.02e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs7834588 0.523 rs1378521 chr8:63834621 T/C cg20602954 chr8:63776762 NKAIN3 0.3 5.03 0.3 9.14e-7 Response to Vitamin E supplementation; CESC cis rs9399401 0.710 rs6900087 chr6:142717303 A/T cg03128060 chr6:142623767 GPR126 0.38 6.4 0.37 7.02e-10 Chronic obstructive pulmonary disease; CESC cis rs12711979 0.765 rs6715805 chr2:3821117 T/C cg17052675 chr2:3827356 NA -0.41 -6.47 -0.37 4.82e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg18230493 chr5:56204884 C5orf35 -0.75 -9.01 -0.48 4.28e-17 Initial pursuit acceleration; CESC cis rs1707322 0.964 rs785483 chr1:46559171 T/C cg06784218 chr1:46089804 CCDC17 -0.33 -5.63 -0.33 4.67e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs1945213 0.694 rs34390414 chr11:55863367 T/G cg03929089 chr4:120376271 NA 0.72 6.85 0.39 5.25e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 6.88 0.39 4.32e-11 Melanoma; CESC cis rs8028182 0.636 rs7163451 chr15:75861076 G/T cg20655648 chr15:75932815 IMP3 0.5 6.17 0.35 2.57e-9 Sudden cardiac arrest; CESC cis rs4253772 0.550 rs11703564 chr22:46722194 G/A cg18190219 chr22:46762943 CELSR1 -0.59 -5.79 -0.33 2.02e-8 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16116244 chr1:16939841 NBPF1 0.63 7.1 0.4 1.13e-11 Gut microbiome composition (summer); CESC cis rs11785400 0.762 rs7460801 chr8:143730972 C/A cg10596483 chr8:143751796 JRK 0.42 5.33 0.31 2.06e-7 Schizophrenia; CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg23034840 chr1:205782522 SLC41A1 0.7 8.66 0.47 4.66e-16 Menarche (age at onset); CESC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.87 0.34 1.27e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04238871 chr10:126431886 FAM53B 0.51 7.32 0.41 3.01e-12 Systemic lupus erythematosus; CESC cis rs1008375 1.000 rs10939738 chr4:17604295 G/C cg02297831 chr4:17616191 MED28 0.52 6.61 0.38 2.1e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs858239 0.539 rs870476 chr7:23193271 C/T cg23682824 chr7:23144976 KLHL7 0.47 6.36 0.36 8.93e-10 Cerebrospinal fluid biomarker levels; CESC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.08e-10 Bipolar disorder; CESC cis rs12136530 0.593 rs12403041 chr1:19730927 A/G cg01832549 chr1:19774989 CAPZB -0.46 -6.3 -0.36 1.23e-9 Lead levels in blood; CESC cis rs2439831 0.850 rs67541383 chr15:44172548 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.66 6.48 0.37 4.38e-10 Lung cancer in ever smokers; CESC cis rs2274273 0.588 rs58296156 chr14:55828327 C/T cg04306507 chr14:55594613 LGALS3 0.3 5.26 0.31 2.92e-7 Protein biomarker; CESC cis rs1152591 0.505 rs1152601 chr14:64667337 T/C cg21174375 chr14:64681225 SYNE2 0.59 8.42 0.46 2.32e-15 Atrial fibrillation; CESC cis rs4555082 0.874 rs11625098 chr14:105756891 A/G cg13114125 chr14:105738426 BRF1 -0.9 -10.61 -0.55 3.82e-22 Mean platelet volume;Platelet distribution width; CESC cis rs7580658 0.963 rs12479003 chr2:128118553 C/T cg10021288 chr2:128175891 PROC -0.41 -6.47 -0.37 4.66e-10 Protein C levels; CESC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.25 0.41 4.59e-12 Height; CESC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg25036284 chr2:26402008 FAM59B -0.84 -9.66 -0.51 4.19e-19 Gut microbiome composition (summer); CESC cis rs847577 0.651 rs10464490 chr7:97715319 T/G cg24562669 chr7:97807699 LMTK2 0.63 10.15 0.53 1.13e-20 Breast cancer; CESC cis rs1728785 1.000 rs7192341 chr16:68569224 G/C cg02972257 chr16:68554789 NA -0.62 -6.93 -0.39 3.14e-11 Ulcerative colitis; CESC cis rs7818345 1.000 rs7011602 chr8:19308915 T/C cg11303988 chr8:19266685 CSGALNACT1 0.34 5.87 0.34 1.29e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg05564831 chr3:52568323 NT5DC2 0.47 7.42 0.41 1.62e-12 Electroencephalogram traits; CESC trans rs61931739 0.500 rs11053212 chr12:34466116 T/G cg26384229 chr12:38710491 ALG10B 0.71 10.64 0.55 3.04e-22 Morning vs. evening chronotype; CESC cis rs4243830 0.737 rs11122085 chr1:6597861 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 0.85 7.42 0.41 1.63e-12 Body mass index; CESC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg19318889 chr4:1322082 MAEA 0.59 7.21 0.41 5.72e-12 Longevity; CESC cis rs7894051 1.000 rs7074435 chr10:135190570 G/T cg12428399 chr10:135191333 PAOX 0.62 5.25 0.31 3.11e-7 Lifespan; CESC cis rs8014204 0.836 rs888413 chr14:75267396 C/T cg08847533 chr14:75593920 NEK9 0.5 6.25 0.36 1.62e-9 Caffeine consumption; CESC cis rs9287719 0.967 rs2010073 chr2:10736478 C/T cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg25036284 chr2:26402008 FAM59B -0.86 -9.4 -0.5 2.74e-18 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06032540 chr15:43941563 CATSPER2 -0.66 -8.0 -0.44 3.92e-14 Gut microbiome composition (summer); CESC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.83 13.45 0.64 8.71e-32 Menarche (age at onset); CESC cis rs4727027 0.870 rs11525060 chr7:148801091 G/A cg23583168 chr7:148888333 NA -0.73 -10.77 -0.55 1.16e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs919433 0.927 rs7592748 chr2:198170688 G/A cg10820045 chr2:198174542 NA -0.38 -5.16 -0.3 4.87e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs8014204 0.743 rs35809608 chr14:75254762 A/G cg08847533 chr14:75593920 NEK9 0.47 5.97 0.34 7.75e-9 Caffeine consumption; CESC cis rs67311347 0.568 rs57287242 chr3:40335538 T/C cg09455208 chr3:40491958 NA 0.37 6.67 0.38 1.48e-10 Renal cell carcinoma; CESC cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg08109568 chr15:31115862 NA -0.5 -6.76 -0.38 8.56e-11 Huntington's disease progression; CESC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg06481639 chr22:41940642 POLR3H 0.55 6.05 0.35 4.91e-9 Vitiligo; CESC cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg05340658 chr4:99064831 C4orf37 0.7 9.08 0.49 2.6e-17 Colonoscopy-negative controls vs population controls; CESC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg06420487 chr17:61919686 SMARCD2 0.45 5.43 0.32 1.3e-7 Height; CESC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg24531977 chr5:56204891 C5orf35 -0.48 -5.86 -0.34 1.38e-8 Coronary artery disease; CESC cis rs6669072 0.647 rs1335727 chr1:91238652 C/T cg08895590 chr1:91227319 NA -0.34 -5.86 -0.34 1.39e-8 Cognitive function; CESC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg18761221 chr20:60518478 NA 0.38 5.06 0.3 7.89e-7 Body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26462404 chr19:2270807 OAZ1 -0.42 -6.11 -0.35 3.58e-9 Gambling; CESC cis rs7949030 0.626 rs61296092 chr11:62320838 T/C cg23462726 chr11:62437636 C11orf83;C11orf48 -0.39 -5.05 -0.3 8.14e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs73206853 0.620 rs28720928 chr12:111126609 C/T cg12870014 chr12:110450643 ANKRD13A 0.73 5.37 0.31 1.69e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs57506017 0.585 rs5011434 chr7:12268717 C/T cg23422036 chr7:12250390 TMEM106B 0.39 5.19 0.3 4.14e-7 Neuroticism; CESC cis rs10838687 0.736 rs3781619 chr11:47255317 C/T cg25783544 chr11:47291846 MADD 0.57 6.55 0.37 3.01e-10 Proinsulin levels; CESC cis rs10493773 0.775 rs2069208 chr1:86117583 T/C cg17807903 chr1:86174739 ZNHIT6 -0.37 -5.03 -0.3 9.19e-7 Urate levels in overweight individuals; CESC cis rs12148488 0.816 rs4886655 chr15:75385568 C/T cg17294928 chr15:75287854 SCAMP5 0.52 6.48 0.37 4.42e-10 Caffeine consumption; CESC cis rs1594829 0.500 rs2046223 chr8:26210178 C/T cg11498726 chr8:26250323 BNIP3L 0.38 5.53 0.32 7.63e-8 Height; CESC cis rs13385 0.769 rs13353859 chr5:139620455 A/G cg26211634 chr5:139558579 C5orf32 0.48 5.27 0.31 2.79e-7 Atrial fibrillation; CESC cis rs1062177 0.855 rs919262 chr5:151266084 C/T cg00977110 chr5:151150581 G3BP1 -0.52 -5.82 -0.34 1.69e-8 Preschool internalizing problems; CESC cis rs55986470 0.763 rs11888775 chr2:239424876 C/T cg18131467 chr2:239335373 ASB1 0.54 6.02 0.35 5.82e-9 Chronotype; CESC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg04025307 chr7:1156635 C7orf50 0.54 9.05 0.49 3.14e-17 Longevity;Endometriosis; CESC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg06873352 chr17:61820015 STRADA -0.73 -12.33 -0.6 6.62e-28 Prudent dietary pattern; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13985271 chr9:97140681 HIATL1 -0.57 -6.19 -0.36 2.25e-9 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg11663144 chr21:46675770 NA -0.62 -9.43 -0.5 2.14e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs35955747 0.902 rs7287402 chr22:31654823 A/G cg25791279 chr22:32026902 PISD 0.48 5.81 0.34 1.78e-8 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg13944838 chr5:179740914 GFPT2 -0.74 -10.05 -0.53 2.34e-20 Height; CESC cis rs1879734 0.731 rs11206196 chr1:54165624 A/G cg23596471 chr1:54105337 GLIS1 0.32 5.46 0.32 1.07e-7 Mitral valve prolapse; CESC cis rs2243480 1.000 rs34560516 chr7:65404092 A/T cg18252515 chr7:66147081 NA -1.18 -10.88 -0.56 5.02e-23 Diabetic kidney disease; CESC cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.09e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.74 0.38 9.76e-11 Bipolar disorder; CESC trans rs17508449 0.865 rs76112502 chr1:114149696 T/C cg23028848 chr11:57092561 TNKS1BP1 -0.77 -6.14 -0.35 2.98e-9 Leprosy; CESC cis rs3741151 0.773 rs79915238 chr11:73272947 C/T cg17517138 chr11:73019481 ARHGEF17 1.03 7.57 0.42 6.07e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00776782 chr1:12677088 DHRS3 0.63 6.78 0.38 8e-11 Gut microbiome composition (summer); CESC cis rs561341 0.883 rs886224 chr17:30229902 T/C cg12193833 chr17:30244370 NA -0.62 -6.22 -0.36 1.97e-9 Hip circumference adjusted for BMI; CESC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg05025164 chr4:1340916 KIAA1530 0.93 12.43 0.61 2.85e-28 Longevity; CESC cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2361710 1.000 rs2361710 chr17:78111877 C/T cg06718696 chr17:78121285 EIF4A3 -0.46 -5.85 -0.34 1.42e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CESC trans rs7246657 0.943 rs7248733 chr19:37996361 A/C cg01833234 chr11:6592585 DNHD1 0.51 6.14 0.35 3.08e-9 Coronary artery calcification; CESC cis rs6701037 0.748 rs11585368 chr1:175135448 G/A cg00321850 chr1:175162397 KIAA0040 -0.41 -5.97 -0.34 7.39e-9 Alcohol dependence; CESC cis rs11734570 0.581 rs73808504 chr4:38600593 T/C cg18361445 chr4:38666374 KLF3;FLJ13197 0.6 7.34 0.41 2.7e-12 Inflammatory bowel disease;Crohn's disease; CESC cis rs2066819 1.000 rs79750959 chr12:56702012 C/A cg26714650 chr12:56694279 CS -1.48 -9.9 -0.52 7.03e-20 Psoriasis vulgaris; CESC cis rs3820068 0.655 rs11587521 chr1:15839206 T/C cg17385448 chr1:15911702 AGMAT 0.38 5.92 0.34 9.72e-9 Systolic blood pressure; CESC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg13393036 chr8:95962371 TP53INP1 0.45 9.2 0.49 1.08e-17 Type 2 diabetes; CESC cis rs7116495 0.609 rs2511120 chr11:71786211 C/T cg10381502 chr11:71823885 C11orf51 -1.1 -6.81 -0.39 6.36e-11 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26988692 chr8:37756473 RAB11FIP1 0.55 6.21 0.36 2.06e-9 Gut microbiome composition (summer); CESC cis rs2380220 0.576 rs4368819 chr6:96031109 T/G cg23517279 chr6:96025343 MANEA 0.54 5.28 0.31 2.66e-7 Behavioural disinhibition (generation interaction); CESC cis rs28489187 0.730 rs12140103 chr1:85849489 G/A cg16011679 chr1:85725395 C1orf52 0.48 5.67 0.33 3.68e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.85 0.43 1.05e-13 Prudent dietary pattern; CESC cis rs748404 0.697 rs498227 chr15:43573052 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.08 0.44 2.26e-14 Lung cancer; CESC cis rs208520 0.690 rs10944872 chr6:66708239 T/G cg07460842 chr6:66804631 NA 0.94 12.61 0.61 7.28e-29 Exhaled nitric oxide output; CESC cis rs12682352 0.602 rs1473029 chr8:8668917 A/C cg06636001 chr8:8085503 FLJ10661 0.42 5.23 0.31 3.43e-7 Neuroticism; CESC cis rs72781680 0.898 rs72780191 chr2:24007122 T/C cg20701182 chr2:24300061 SF3B14 0.78 6.7 0.38 1.22e-10 Lymphocyte counts; CESC cis rs2522056 1.000 rs1003533 chr5:131755651 C/T cg24060327 chr5:131705240 SLC22A5 0.64 7.3 0.41 3.44e-12 Lymphocyte counts;Fibrinogen; CESC cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -7.55 -0.42 6.87e-13 Alzheimer's disease; CESC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg22968622 chr17:43663579 NA -0.79 -10.63 -0.55 3.19e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg16606324 chr3:10149918 C3orf24 0.41 5.1 0.3 6.38e-7 Alzheimer's disease; CESC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg00166722 chr3:10149974 C3orf24 0.42 5.85 0.34 1.45e-8 Alzheimer's disease; CESC cis rs10208940 0.764 rs6737302 chr2:68782837 A/G cg12452813 chr2:68675892 NA 0.52 5.16 0.3 4.88e-7 Urate levels in lean individuals; CESC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -6.76 -0.38 9.02e-11 Bipolar disorder and schizophrenia; CESC cis rs4523957 0.553 rs2476355 chr17:2029559 A/G cg16513277 chr17:2031491 SMG6 -0.79 -11.71 -0.58 8.09e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg13902645 chr11:5959945 NA -0.66 -7.99 -0.44 4.21e-14 DNA methylation (variation); CESC cis rs56804039 1.000 rs59620654 chr8:8382632 A/G cg15556689 chr8:8085844 FLJ10661 -0.48 -5.2 -0.3 4.05e-7 Cervical cancer; CESC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg13114125 chr14:105738426 BRF1 -0.77 -9.49 -0.5 1.4e-18 Mean platelet volume;Platelet distribution width; CESC cis rs921968 0.643 rs552882 chr2:219401726 G/A cg02176678 chr2:219576539 TTLL4 0.42 7.44 0.42 1.43e-12 Mean corpuscular hemoglobin concentration; CESC cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg05340658 chr4:99064831 C4orf37 0.75 10.97 0.56 2.53e-23 Colonoscopy-negative controls vs population controls; CESC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.39 5.11 0.3 6.29e-7 Lymphocyte counts; CESC cis rs1847202 0.563 rs13095184 chr3:72951008 A/G cg25664220 chr3:72788482 NA -0.38 -5.57 -0.32 6.3e-8 Motion sickness; CESC cis rs4722166 0.695 rs4722177 chr7:22798531 T/C cg05265849 chr7:22767390 IL6 0.46 6.31 0.36 1.17e-9 Lung cancer; CESC cis rs7084402 0.967 rs11006170 chr10:60276369 T/C cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC trans rs17685 0.712 rs60721456 chr7:75743820 T/A cg19862616 chr7:65841803 NCRNA00174 0.75 10.73 0.55 1.51e-22 Coffee consumption;Coffee consumption (cups per day); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12351856 chr18:19192308 SNRPD1 -0.45 -6.33 -0.36 1.03e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs3820068 0.705 rs7533125 chr1:15883744 T/C cg17385448 chr1:15911702 AGMAT 0.37 5.81 0.34 1.8e-8 Systolic blood pressure; CESC cis rs4919694 0.901 rs10509763 chr10:104776391 G/A cg04362960 chr10:104952993 NT5C2 0.74 6.38 0.37 7.75e-10 Arsenic metabolism; CESC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg12463550 chr7:65579703 CRCP 0.51 6.36 0.36 8.66e-10 Aortic root size; CESC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg01341218 chr17:43662625 NA 0.53 7.07 0.4 1.4e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs75804782 0.641 rs11885523 chr2:239344263 G/A cg18131467 chr2:239335373 ASB1 -0.68 -5.91 -0.34 1.03e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs796364 0.806 rs10445792 chr2:201078821 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -5.97 -0.34 7.44e-9 Schizophrenia; CESC cis rs2243480 1.000 rs419603 chr7:65597341 C/T cg13147721 chr7:65941812 NA -0.99 -9.4 -0.5 2.68e-18 Diabetic kidney disease; CESC cis rs12477438 0.798 rs4324365 chr2:99623845 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18216292 chr1:155920810 ARHGEF2 -0.57 -6.54 -0.37 3.18e-10 Gut microbiome composition (summer); CESC trans rs2235573 0.527 rs139885 chr22:38371039 C/T cg19894588 chr14:64061835 NA 0.59 7.63 0.42 4.24e-13 Glioblastoma;Glioma; CESC cis rs12824058 0.831 rs4759657 chr12:130815818 G/A cg23887609 chr12:130822674 PIWIL1 0.45 5.86 0.34 1.38e-8 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01877967 chr7:56148907 PHKG1 0.54 7.2 0.4 6.23e-12 Fibrinogen levels; CESC cis rs919433 0.854 rs787994 chr2:198223121 T/C cg10820045 chr2:198174542 NA 0.39 5.78 0.33 2.08e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg08470875 chr2:26401718 FAM59B 0.75 7.79 0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs2228479 1.000 rs12596492 chr16:89957169 T/G cg04013166 chr16:89971882 TCF25 0.76 6.53 0.37 3.28e-10 Skin colour saturation; CESC cis rs3820068 0.559 rs6675334 chr1:15923580 A/T cg17385448 chr1:15911702 AGMAT 0.44 7.29 0.41 3.67e-12 Systolic blood pressure; CESC cis rs2006771 0.818 rs8142376 chr22:32001037 C/T cg25791279 chr22:32026902 PISD -0.46 -5.7 -0.33 3.2e-8 Nonsyndromic cleft lip with cleft palate; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03729288 chr17:7232752 NEURL4 -0.49 -6.72 -0.38 1.08e-10 Fibrinogen levels; CESC cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.24 0.36 1.77e-9 Hip circumference adjusted for BMI; CESC cis rs2243480 1.000 rs427044 chr7:65508545 G/A cg25894440 chr7:65020034 NA -0.61 -5.12 -0.3 5.89e-7 Diabetic kidney disease; CESC cis rs7084402 0.935 rs1896246 chr10:60276068 A/G cg07615347 chr10:60278583 BICC1 -0.59 -9.42 -0.5 2.33e-18 Refractive error; CESC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.88 9.6 0.51 6.39e-19 Mean platelet volume; CESC cis rs796364 0.806 rs78037592 chr2:201105734 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.76 -6.21 -0.36 2.09e-9 Schizophrenia; CESC cis rs9287719 0.967 rs6432117 chr2:10749359 G/C cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs3820068 0.705 rs4646091 chr1:15822043 T/C cg18192808 chr1:15853278 DNAJC16 0.47 5.78 0.33 2.05e-8 Systolic blood pressure; CESC cis rs13191362 0.808 rs13217502 chr6:163231414 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.59 5.88 0.34 1.22e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7264396 0.635 rs6060710 chr20:34536055 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -11.3 -0.57 1.94e-24 Total cholesterol levels; CESC cis rs4237845 0.844 rs7306124 chr12:58303349 A/T cg00677455 chr12:58241039 CTDSP2 0.55 7.11 0.4 1.06e-11 Intelligence (multi-trait analysis); CESC cis rs7772486 0.875 rs6914813 chr6:146397798 A/G cg05347473 chr6:146136440 FBXO30 0.51 6.68 0.38 1.36e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13369981 chr7:100027501 MEPCE;ZCWPW1 0.57 6.77 0.38 8.15e-11 Gut microbiome composition (summer); CESC cis rs7937682 0.847 rs583032 chr11:111432757 C/T cg09085632 chr11:111637200 PPP2R1B -0.95 -13.83 -0.65 3.96e-33 Primary sclerosing cholangitis; CESC cis rs7605827 0.897 rs6431713 chr2:15691382 C/T cg19274914 chr2:15703543 NA 0.36 6.39 0.37 7.29e-10 Educational attainment (years of education); CESC cis rs6714710 0.603 rs34373359 chr2:98442202 G/A cg26665480 chr2:98280029 ACTR1B 0.6 8.23 0.45 8.31e-15 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs1023500 0.596 rs5751209 chr22:42451603 A/G cg15557168 chr22:42548783 NA -0.41 -5.31 -0.31 2.32e-7 Schizophrenia; CESC cis rs6088580 0.634 rs6088475 chr20:32964987 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -7.01 -0.4 2.01e-11 Glomerular filtration rate (creatinine); CESC cis rs9309711 0.961 rs35067331 chr2:3474085 C/T cg10845886 chr2:3471009 TTC15 -0.84 -11.45 -0.58 6.34e-25 Neurofibrillary tangles; CESC cis rs7762018 0.660 rs41265385 chr6:170068086 C/T cg05834625 chr6:170176447 C6orf70 0.51 5.53 0.32 7.75e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs561341 0.883 rs2074102 chr17:30228884 G/A cg19193384 chr17:30244184 NA -0.55 -5.62 -0.33 4.73e-8 Hip circumference adjusted for BMI; CESC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.33 -0.31 2.15e-7 Lung cancer; CESC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg07648498 chr16:89883185 FANCA 0.44 5.44 0.32 1.2e-7 Vitiligo; CESC cis rs7107174 0.892 rs2512529 chr11:77977351 C/T cg02023728 chr11:77925099 USP35 0.48 6.6 0.38 2.28e-10 Testicular germ cell tumor; CESC cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg18904891 chr8:8559673 CLDN23 -0.43 -5.07 -0.3 7.34e-7 Neuroticism; CESC cis rs4253772 0.591 rs8135363 chr22:46651713 T/C cg09491104 chr22:46646882 C22orf40 -0.59 -9.15 -0.49 1.58e-17 LDL cholesterol;Cholesterol, total; CESC cis rs4835473 0.932 rs1849118 chr4:144910975 T/C cg25736465 chr4:144833511 NA 0.42 6.39 0.37 7.37e-10 Immature fraction of reticulocytes; CESC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg02725872 chr8:58115012 NA -0.34 -5.31 -0.31 2.36e-7 Developmental language disorder (linguistic errors); CESC cis rs72781680 0.898 rs72788212 chr2:24087385 G/A cg20701182 chr2:24300061 SF3B14 0.62 5.68 0.33 3.54e-8 Lymphocyte counts; CESC cis rs2806561 0.765 rs668234 chr1:23515467 G/A cg12483005 chr1:23474871 LUZP1 0.38 6.0 0.35 6.44e-9 Height; CESC cis rs6558174 0.965 rs2009212 chr8:22491496 G/A cg03733263 chr8:22462867 KIAA1967 0.47 6.32 0.36 1.1e-9 Breast cancer; CESC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg08470875 chr2:26401718 FAM59B -0.73 -7.97 -0.44 4.87e-14 Gut microbiome composition (summer); CESC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg20607287 chr7:12443886 VWDE -0.7 -8.49 -0.46 1.46e-15 Coronary artery disease; CESC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg10691866 chr7:65817282 TPST1 -0.32 -5.04 -0.3 8.78e-7 Aortic root size; CESC cis rs9796 0.804 rs28688742 chr15:41403638 G/A cg12426344 chr15:41135900 SPINT1 -0.24 -5.28 -0.31 2.69e-7 Menopause (age at onset); CESC cis rs16858210 0.874 rs34113436 chr3:183573836 G/A cg25686905 chr3:183603175 PARL -0.34 -6.45 -0.37 5.41e-10 Menopause (age at onset); CESC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg11494091 chr17:61959527 GH2 0.72 12.33 0.6 6.37e-28 Prudent dietary pattern; CESC cis rs2204008 0.713 rs12366709 chr12:38210179 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs3820068 0.581 rs6693694 chr1:15980135 G/T cg18133145 chr1:16060689 PLEKHM2 -0.4 -5.15 -0.3 5.15e-7 Systolic blood pressure; CESC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg05315796 chr3:52349193 DNAH1 0.37 6.14 0.35 3.01e-9 Bipolar disorder; CESC cis rs11098499 0.697 rs10016448 chr4:120298845 A/G cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg00166722 chr3:10149974 C3orf24 0.48 5.98 0.34 7.06e-9 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14716208 chr3:52089752 DUSP7 -0.44 -6.0 -0.35 6.41e-9 Fibrinogen levels; CESC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg26839252 chr6:160211577 TCP1;MRPL18 0.49 6.15 0.35 2.83e-9 Age-related macular degeneration (geographic atrophy); CESC cis rs9287719 0.566 rs34595606 chr2:10722518 G/A cg00105475 chr2:10696890 NA 0.4 5.35 0.31 1.94e-7 Prostate cancer; CESC cis rs847577 0.722 rs7790736 chr7:97713039 G/A cg24562669 chr7:97807699 LMTK2 0.63 10.27 0.53 4.67e-21 Breast cancer; CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.48 7.54 0.42 7.64e-13 Cognitive function; CESC cis rs3741404 0.609 rs635139 chr11:63872210 A/G cg18225595 chr11:63971243 STIP1 0.5 6.59 0.38 2.39e-10 Platelet count; CESC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 6.95 0.39 2.84e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20781241 chr15:74907290 CLK3 0.59 6.61 0.38 2.1e-10 Gut microbiome composition (summer); CESC cis rs826838 1.000 rs1095575 chr12:39110284 C/G cg26384229 chr12:38710491 ALG10B -0.62 -9.91 -0.52 6.55e-20 Heart rate; CESC cis rs523522 0.962 rs3213565 chr12:120992401 C/T cg12219531 chr12:120966889 COQ5 0.74 9.75 0.51 2.17e-19 High light scatter reticulocyte count; CESC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg00129232 chr17:37814104 STARD3 0.6 8.04 0.44 3.04e-14 Glomerular filtration rate (creatinine); CESC cis rs9796 0.611 rs691672 chr15:41444438 A/C cg12426344 chr15:41135900 SPINT1 -0.24 -5.31 -0.31 2.35e-7 Menopause (age at onset); CESC cis rs4253772 0.614 rs11090859 chr22:46687460 T/G cg18190219 chr22:46762943 CELSR1 -0.46 -5.81 -0.34 1.82e-8 LDL cholesterol;Cholesterol, total; CESC cis rs2735413 0.709 rs9938043 chr16:78091426 A/G cg04733911 chr16:78082701 NA -0.47 -7.31 -0.41 3.12e-12 Systolic blood pressure (alcohol consumption interaction); CESC trans rs4349753 0.640 rs10037082 chr5:144075537 T/C cg22407458 chr6:35109121 TCP11 0.5 6.29 0.36 1.31e-9 Photic sneeze reflex; CESC cis rs9911578 0.785 rs10853008 chr17:56993407 T/C cg12560992 chr17:57184187 TRIM37 -0.9 -12.25 -0.6 1.26e-27 Intelligence (multi-trait analysis); CESC cis rs35955747 0.533 rs5998004 chr22:31881829 C/T cg25791279 chr22:32026902 PISD -0.43 -5.09 -0.3 6.72e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs727505 1.000 rs10244817 chr7:124467470 T/C cg23710748 chr7:124431027 NA -0.48 -7.55 -0.42 6.85e-13 Lewy body disease; CESC cis rs7249142 0.549 rs7260127 chr19:19280499 C/T cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B -0.28 -5.08 -0.3 7.14e-7 IgG glycosylation; CESC cis rs1878931 0.696 rs35175748 chr16:3445427 C/G cg00484396 chr16:3507460 NAT15 -0.43 -6.68 -0.38 1.41e-10 Body mass index (adult); CESC cis rs10823500 0.748 rs7072230 chr10:71978144 A/G cg04118878 chr10:71993077 PPA1 0.47 5.56 0.32 6.61e-8 Blood protein levels; CESC cis rs12586317 0.547 rs28577270 chr14:35498443 G/A cg16230307 chr14:35515116 FAM177A1 0.99 10.61 0.55 3.72e-22 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12853981 chr14:58862714 TOMM20L 0.57 6.32 0.36 1.09e-9 Gut microbiome composition (summer); CESC cis rs2742234 0.590 rs2503863 chr10:43667398 G/A cg07801480 chr10:43725741 RASGEF1A 0.41 5.29 0.31 2.56e-7 Hirschsprung disease; CESC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg25072359 chr17:41440525 NA 0.47 6.3 0.36 1.23e-9 Menopause (age at onset); CESC cis rs4716602 0.898 rs10249494 chr7:156159448 G/T cg04090468 chr7:156181990 NA 0.4 5.11 0.3 6.28e-7 Anti-saccade response; CESC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg12463550 chr7:65579703 CRCP -0.48 -6.17 -0.35 2.6e-9 Aortic root size; CESC cis rs10870270 0.957 rs7074604 chr10:133740373 G/C cg08754478 chr10:133766260 PPP2R2D -0.62 -8.06 -0.44 2.63e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1580019 0.885 rs4580942 chr7:32496435 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.73 9.88 0.52 8.14e-20 Cognitive ability; CESC cis rs9660992 0.700 rs1172125 chr1:205258442 A/T cg21643547 chr1:205240462 TMCC2 -0.48 -7.08 -0.4 1.29e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs7089973 0.872 rs17092497 chr10:116612628 G/A cg23260525 chr10:116636907 FAM160B1 0.37 6.22 0.36 1.95e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.22e-12 Tonsillectomy; CESC cis rs12893668 0.703 rs2403197 chr14:104053764 C/T cg24130564 chr14:104152367 KLC1 -0.48 -6.01 -0.35 6.16e-9 Reticulocyte count; CESC cis rs2652822 0.967 rs1472631 chr15:63423739 A/G cg02713581 chr15:63449717 RPS27L 0.56 7.16 0.4 7.96e-12 Metabolic traits; CESC cis rs8114671 0.562 rs1018447 chr20:33401707 A/G cg24642439 chr20:33292090 TP53INP2 -0.42 -5.16 -0.3 4.94e-7 Height; CESC cis rs11867934 0.577 rs9893676 chr17:17054951 C/G cg26176665 chr17:16994978 MPRIP 0.4 5.4 0.32 1.46e-7 Diabetic retinopathy; CESC cis rs703842 0.963 rs923829 chr12:58174306 T/C cg00677455 chr12:58241039 CTDSP2 0.52 6.86 0.39 4.72e-11 Multiple sclerosis; CESC cis rs4974559 0.947 rs10000012 chr4:1357325 C/G cg02980000 chr4:1222292 CTBP1 -0.67 -6.27 -0.36 1.46e-9 Systolic blood pressure; CESC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.89 0.39 4.13e-11 Bipolar disorder; CESC cis rs911555 0.755 rs7148567 chr14:103882234 C/T cg24130564 chr14:104152367 KLC1 -0.52 -7.05 -0.4 1.56e-11 Intelligence (multi-trait analysis); CESC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg13770153 chr20:60521292 NA -0.53 -6.89 -0.39 4.06e-11 Body mass index; CESC cis rs1008375 0.933 rs10939757 chr4:17694125 T/C cg16339924 chr4:17578868 LAP3 0.58 7.08 0.4 1.33e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8060686 0.516 rs7189794 chr16:68277727 T/C cg26727032 chr16:67993705 SLC12A4 -0.53 -7.07 -0.4 1.35e-11 HDL cholesterol;Metabolic syndrome; CESC cis rs7945705 0.902 rs10743093 chr11:8869129 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.35 5.63 0.33 4.67e-8 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19189310 chr6:34393779 RPS10 0.6 6.75 0.38 9.37e-11 Gut microbiome composition (summer); CESC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg07648498 chr16:89883185 FANCA 0.44 5.56 0.32 6.59e-8 Vitiligo; CESC cis rs10744422 0.920 rs10773657 chr12:123327900 C/A cg22842854 chr12:123319900 HIP1R -0.62 -5.1 -0.3 6.33e-7 Schizophrenia; CESC cis rs4654899 1.000 rs4654902 chr1:21435056 T/G cg05370193 chr1:21551575 ECE1 0.4 6.03 0.35 5.41e-9 Superior frontal gyrus grey matter volume; CESC cis rs7044106 0.537 rs10818474 chr9:123489964 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.67 8.49 0.46 1.48e-15 Hip circumference adjusted for BMI; CESC cis rs12220238 1.000 rs10824114 chr10:75970503 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.45 0.32 1.13e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs10979 1.000 rs6570565 chr6:143899531 C/T cg25407410 chr6:143891975 LOC285740 -0.61 -9.03 -0.48 3.7e-17 Hypospadias; CESC cis rs7809950 0.911 rs1015411 chr7:107135612 C/T cg23024343 chr7:107201750 COG5 -0.43 -5.97 -0.34 7.72e-9 Coronary artery disease; CESC cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg27165867 chr14:105738592 BRF1 -0.52 -5.65 -0.33 4.2e-8 Mean platelet volume;Platelet distribution width; CESC cis rs6963495 0.674 rs75880756 chr7:105163821 G/C cg02135003 chr7:105160482 PUS7 -0.47 -5.59 -0.33 5.51e-8 Bipolar disorder (body mass index interaction); CESC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg18350739 chr11:68623251 NA -0.45 -6.63 -0.38 1.92e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs916888 0.773 rs199439 chr17:44793503 A/G cg01570182 chr17:44337453 NA 0.9 10.27 0.53 4.95e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs4843747 0.803 rs72818522 chr16:88059144 C/T cg17633681 chr16:88106987 BANP 0.69 8.74 0.47 2.68e-16 Menopause (age at onset); CESC cis rs17376456 0.569 rs35878747 chr5:93094070 C/A cg25358565 chr5:93447407 FAM172A 0.67 7.16 0.4 7.97e-12 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21650900 chr2:235405122 ARL4C 0.54 6.2 0.36 2.19e-9 Gut microbiome composition (summer); CESC cis rs2124969 0.548 rs72982036 chr2:161031590 G/A cg03641300 chr2:160917029 PLA2R1 -0.57 -5.99 -0.35 6.83e-9 Waist circumference adjusted for body mass index; CESC cis rs77741769 0.529 rs12579868 chr12:121207147 C/T cg02419362 chr12:121203948 SPPL3 0.36 5.77 0.33 2.26e-8 Mean corpuscular volume; CESC cis rs9443189 0.570 rs6903448 chr6:76173832 C/T cg01950844 chr6:76311363 SENP6 0.56 5.31 0.31 2.29e-7 Prostate cancer; CESC trans rs2216164 0.966 rs12315837 chr12:68573003 C/A cg27495728 chr7:99067116 NA -0.35 -6.26 -0.36 1.56e-9 Alopecia areata; CESC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs7617773 0.817 rs3731497 chr3:48226553 T/G cg11946769 chr3:48343235 NME6 0.8 10.29 0.53 4.08e-21 Coronary artery disease; CESC cis rs6701037 0.875 rs6929 chr1:175126721 A/G cg00321850 chr1:175162397 KIAA0040 -0.4 -5.6 -0.33 5.46e-8 Alcohol dependence; CESC trans rs73568641 0.546 rs12524666 chr6:154088541 A/T cg08374472 chr16:87445639 ZCCHC14 -0.47 -6.25 -0.36 1.66e-9 Methadone dose in opioid dependence; CESC cis rs1729951 0.546 rs361246 chr3:136695667 G/A cg04103450 chr3:136751342 NA 0.41 5.44 0.32 1.19e-7 Neuroticism; CESC cis rs4900538 0.855 rs762105 chr14:102830175 A/G cg18135206 chr14:102964638 TECPR2 -0.75 -9.43 -0.5 2.18e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs8077889 0.750 rs76557360 chr17:41936842 G/A cg26893861 chr17:41843967 DUSP3 0.86 8.47 0.46 1.77e-15 Triglycerides; CESC cis rs6088590 1.000 rs6088615 chr20:33400474 C/T cg24642439 chr20:33292090 TP53INP2 -0.77 -10.27 -0.53 4.77e-21 Coronary artery disease; CESC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg18876405 chr7:65276391 NA -0.49 -6.72 -0.38 1.11e-10 Aortic root size; CESC cis rs7829975 0.774 rs13259216 chr8:8673601 A/C cg06636001 chr8:8085503 FLJ10661 0.46 6.07 0.35 4.45e-9 Mood instability; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06867543 chr15:77271730 NA 0.49 7.07 0.4 1.39e-11 Fibrinogen levels; CESC cis rs6963495 0.818 rs73190167 chr7:105160418 A/G cg19920283 chr7:105172520 RINT1 0.69 6.56 0.37 2.85e-10 Bipolar disorder (body mass index interaction); CESC cis rs7178572 1.000 rs2055901 chr15:77759295 G/A cg22256960 chr15:77711686 NA -0.59 -7.96 -0.44 5e-14 Type 2 diabetes; CESC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg10074409 chr1:209979377 IRF6 0.34 5.57 0.32 6.28e-8 Cleft lip with or without cleft palate; CESC cis rs2288073 0.801 rs10176347 chr2:24367994 G/A cg06627628 chr2:24431161 ITSN2 -0.71 -9.07 -0.49 2.8e-17 Venous thromboembolism (SNP x SNP interaction); CESC cis rs12477438 0.798 rs12468419 chr2:99579680 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -9.2 -0.49 1.14e-17 Chronic sinus infection; CESC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg11764359 chr7:65958608 NA 0.67 8.62 0.47 6.29e-16 Calcium levels; CESC cis rs6570726 0.935 rs429306 chr6:145827016 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs734999 0.588 rs2843403 chr1:2529097 T/C cg20673091 chr1:2541236 MMEL1 -0.43 -7.33 -0.41 2.76e-12 Ulcerative colitis; CESC cis rs57506017 0.585 rs1054168 chr7:12273413 C/T cg23422036 chr7:12250390 TMEM106B 0.39 5.17 0.3 4.57e-7 Neuroticism; CESC cis rs11190604 1.000 rs7099913 chr10:102314777 T/C cg07080220 chr10:102295463 HIF1AN 0.57 5.52 0.32 8.11e-8 Palmitoleic acid (16:1n-7) levels; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg06184463 chr3:11888509 C3orf31 0.45 6.15 0.35 2.88e-9 Weight; CESC cis rs763014 0.898 rs2017567 chr16:637212 T/C cg00908189 chr16:619842 PIGQ 0.65 9.08 0.49 2.49e-17 Height; CESC cis rs7267979 0.966 rs6037083 chr20:25290543 T/C cg08601574 chr20:25228251 PYGB -0.39 -5.58 -0.32 6.03e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1348850 0.598 rs1405717 chr2:178500101 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.38 0.41 2.1e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9287719 0.967 rs4470306 chr2:10743998 C/T cg00105475 chr2:10696890 NA 0.39 5.63 0.33 4.6e-8 Prostate cancer; CESC cis rs11871801 0.517 rs665268 chr17:40722029 A/G cg14558262 chr17:40713999 COASY 0.5 5.85 0.34 1.46e-8 Crohn's disease; CESC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg06873352 chr17:61820015 STRADA 0.72 12.83 0.62 1.2e-29 Prudent dietary pattern; CESC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg05368731 chr17:41323189 NBR1 0.77 10.72 0.55 1.69e-22 Menopause (age at onset); CESC cis rs2832191 0.791 rs2832179 chr21:30480366 C/T cg08807101 chr21:30365312 RNF160 -0.76 -10.82 -0.55 7.78e-23 Dental caries; CESC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.74 0.43 2.06e-13 Prudent dietary pattern; CESC cis rs1387259 0.790 rs2732445 chr12:48645533 C/T cg04545296 chr12:48745243 ZNF641 0.41 6.85 0.39 5.09e-11 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs10788264 0.504 rs4751883 chr10:124018027 A/C cg09507567 chr10:124027408 NA 0.38 5.25 0.31 3.13e-7 Total body bone mineral density; CESC cis rs524281 0.731 rs10791841 chr11:65808587 T/C cg14036092 chr11:66035641 RAB1B -0.58 -5.36 -0.31 1.84e-7 Electroencephalogram traits; CESC cis rs8092503 1.000 rs12966541 chr18:52481402 C/G cg12377874 chr18:52495404 RAB27B 0.38 6.2 0.36 2.13e-9 Childhood body mass index; CESC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg07677032 chr17:61819896 STRADA 0.5 6.7 0.38 1.24e-10 Prudent dietary pattern; CESC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg13206674 chr6:150067644 NUP43 0.42 6.18 0.36 2.37e-9 Lung cancer; CESC cis rs4925386 0.840 rs6142738 chr20:60919960 C/T cg22307297 chr20:60903441 LAMA5 -0.36 -5.17 -0.3 4.54e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs1881797 1.000 rs10925069 chr1:247681313 C/T cg05639522 chr1:247681581 NA -0.52 -7.0 -0.39 2.14e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs7726839 0.561 rs56410216 chr5:583216 C/A cg16447950 chr5:562315 NA -0.55 -6.19 -0.36 2.29e-9 Obesity-related traits; CESC cis rs1372520 0.564 rs356196 chr4:90682803 A/T cg15133208 chr4:90757351 SNCA 0.43 5.12 0.3 5.78e-7 Neuroticism; CESC cis rs614226 1.000 rs1167726 chr12:120967364 A/C cg01236616 chr12:121019343 POP5 -1.51 -19.53 -0.77 3e-53 Type 1 diabetes nephropathy; CESC cis rs1728785 1.000 rs8058314 chr16:68584151 G/A cg02972257 chr16:68554789 NA -0.54 -6.27 -0.36 1.45e-9 Ulcerative colitis; CESC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg15369054 chr17:80825471 TBCD -0.44 -6.0 -0.35 6.45e-9 Breast cancer; CESC cis rs7618501 1.000 rs34451146 chr3:49813013 C/T cg24308560 chr3:49941425 MST1R -0.49 -6.74 -0.38 9.66e-11 Intelligence (multi-trait analysis); CESC cis rs4919687 0.550 rs12259058 chr10:104484799 A/G cg04362960 chr10:104952993 NT5C2 0.48 5.45 0.32 1.18e-7 Colorectal cancer; CESC cis rs10870270 0.957 rs3829156 chr10:133789386 C/G cg08754478 chr10:133766260 PPP2R2D -0.57 -7.42 -0.41 1.64e-12 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7845219 0.544 rs4735332 chr8:95923660 C/T cg23172400 chr8:95962367 TP53INP1 -0.38 -7.21 -0.4 5.89e-12 Type 2 diabetes; CESC cis rs11608355 0.545 rs2302708 chr12:109893726 A/C cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs476633 0.691 rs28735224 chr15:41537539 C/T cg12386646 chr15:41787261 ITPKA 0.36 5.44 0.32 1.22e-7 Glomerular filtration rate (creatinine); CESC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg22823121 chr1:150693482 HORMAD1 0.36 5.12 0.3 5.88e-7 Tonsillectomy; CESC cis rs208520 0.690 rs3899423 chr6:66835285 A/G cg07460842 chr6:66804631 NA -0.94 -13.3 -0.63 2.87e-31 Exhaled nitric oxide output; CESC cis rs1008375 1.000 rs2286771 chr4:17643848 G/A cg16339924 chr4:17578868 LAP3 0.56 7.02 0.4 1.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg15605315 chr1:45957053 TESK2 0.48 6.43 0.37 5.79e-10 High light scatter reticulocyte count; CESC cis rs12458462 0.892 rs35928863 chr18:77438956 A/G cg11879182 chr18:77439856 CTDP1 0.85 13.03 0.63 2.43e-30 Monocyte count; CESC cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg25517755 chr10:38738941 LOC399744 -0.47 -6.04 -0.35 5.28e-9 Extrinsic epigenetic age acceleration; CESC cis rs2932538 0.583 rs2279500 chr1:113244433 T/C cg22162597 chr1:113214053 CAPZA1 -0.49 -5.17 -0.3 4.61e-7 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs72627123 0.867 rs73303107 chr14:74477284 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.79 5.8 0.34 1.92e-8 Morning vs. evening chronotype; CESC cis rs7714584 1.000 rs10051924 chr5:150226639 T/C cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC cis rs3741151 0.773 rs61345051 chr11:73112305 T/C cg17517138 chr11:73019481 ARHGEF17 0.98 7.14 0.4 8.91e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21124756 chr1:1447564 ATAD3A 0.54 6.24 0.36 1.71e-9 Gut microbiome composition (summer); CESC trans rs7628583 0.696 rs12488626 chr3:64071952 C/A cg17243659 chr21:48055224 PRMT2 -0.56 -6.01 -0.35 6.14e-9 Parental extreme longevity (95 years and older); CESC cis rs4957048 0.891 rs11960196 chr5:568857 C/A cg09021430 chr5:549028 NA -0.48 -6.57 -0.37 2.6e-10 Ulcerative colitis; CESC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg02569458 chr12:86230093 RASSF9 0.51 7.63 0.42 4.33e-13 Major depressive disorder; CESC cis rs4660261 0.526 rs803680 chr1:44364370 G/C cg15962314 chr1:44399869 ARTN 0.27 5.11 0.3 6.04e-7 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12737030 chr10:73975246 ASCC1;C10orf104 0.4 6.08 0.35 4.21e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19102404 chr1:116941269 C1orf203;ATP1A1 -0.53 -6.56 -0.37 2.86e-10 Gut microbiome composition (summer); CESC cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg22875332 chr1:76189707 ACADM 0.55 5.39 0.31 1.55e-7 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7772486 0.846 rs9376976 chr6:146355605 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.51 0.37 3.72e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2439831 0.702 rs2788 chr15:44064886 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.7 6.72 0.38 1.14e-10 Lung cancer in ever smokers; CESC cis rs9976767 0.637 rs2277799 chr21:43824123 G/C cg23042151 chr21:43824109 UBASH3A -0.36 -6.79 -0.38 7.32e-11 Type 1 diabetes; CESC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg18099408 chr3:52552593 STAB1 -0.3 -5.03 -0.3 9.18e-7 Bipolar disorder; CESC cis rs9300255 0.543 rs655293 chr12:123528405 G/A cg05973401 chr12:123451056 ABCB9 0.59 6.43 0.37 5.84e-10 Neutrophil percentage of white cells; CESC cis rs72781680 0.800 rs72790306 chr2:24111311 T/G cg08917208 chr2:24149416 ATAD2B 1.11 10.15 0.53 1.13e-20 Lymphocyte counts; CESC cis rs12995491 0.933 rs34366691 chr2:88537451 G/A cg14558114 chr2:88469736 THNSL2 -0.49 -7.13 -0.4 9.46e-12 Response to metformin (IC50); CESC cis rs7560272 0.723 rs1083923 chr2:73703374 A/G cg20560298 chr2:73613845 ALMS1 0.49 7.09 0.4 1.21e-11 Schizophrenia; CESC cis rs4969178 0.965 rs11653305 chr17:76386918 T/C cg05887092 chr17:76393375 PGS1 0.59 9.27 0.49 6.61e-18 HDL cholesterol levels; CESC cis rs7937682 0.602 rs4936804 chr11:111743851 A/C cg09085632 chr11:111637200 PPP2R1B 0.9 11.72 0.58 8.02e-26 Primary sclerosing cholangitis; CESC cis rs117623576 0.941 rs72778753 chr10:32426579 A/T cg03047570 chr10:32398778 NA -0.57 -5.57 -0.32 6.11e-8 Anti-saccade response; CESC cis rs12887734 0.569 rs66953418 chr14:104271470 G/A cg01849466 chr14:104193079 ZFYVE21 -0.44 -5.63 -0.33 4.71e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 9.75 0.51 2.1e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs60154123 0.772 rs614167 chr1:210425895 T/C cg21951975 chr1:209979733 IRF6 0.48 6.03 0.35 5.35e-9 Coronary artery disease; CESC cis rs9926296 0.682 rs258328 chr16:89730314 C/T cg03605463 chr16:89740564 NA 0.64 7.81 0.43 1.34e-13 Vitiligo; CESC cis rs11683229 0.704 rs12991414 chr2:63103597 C/A cg17519650 chr2:63277830 OTX1 -0.68 -5.46 -0.32 1.11e-7 Protein quantitative trait loci; CESC cis rs7980687 0.527 rs28533432 chr12:123873242 C/T cg00376283 chr12:123451042 ABCB9 0.5 6.38 0.36 8e-10 Height;Educational attainment;Head circumference (infant); CESC cis rs1707322 1.000 rs785510 chr1:46528618 T/C cg05343316 chr1:45956843 TESK2 -0.48 -5.68 -0.33 3.62e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs67311347 1.000 rs7625736 chr3:40441345 C/G cg24209194 chr3:40518798 ZNF619 -0.5 -6.72 -0.38 1.1e-10 Renal cell carcinoma; CESC cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs62064224 0.703 rs62065493 chr17:30822620 C/G cg12855166 chr17:30846586 MYO1D 0.4 5.11 0.3 6.15e-7 Schizophrenia; CESC cis rs8114671 0.562 rs1018447 chr20:33401707 A/G cg08999081 chr20:33150536 PIGU -0.4 -5.87 -0.34 1.3e-8 Height; CESC cis rs17253792 0.822 rs9972178 chr14:56073480 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs9300255 0.602 rs949142 chr12:123634043 T/C cg05973401 chr12:123451056 ABCB9 0.51 5.72 0.33 2.81e-8 Neutrophil percentage of white cells; CESC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg17340268 chr14:105411764 AHNAK2 -0.52 -6.92 -0.39 3.36e-11 Rheumatoid arthritis; CESC cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg05535760 chr7:792225 HEATR2 0.87 10.87 0.56 5.18e-23 Cerebrospinal P-tau181p levels; CESC cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg03467027 chr4:99064603 C4orf37 0.42 5.26 0.31 3.01e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12142240 0.621 rs66828173 chr1:46818166 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs17807624 1.000 rs17807624 chr8:11463015 A/G cg12395012 chr8:11607386 GATA4 0.36 5.33 0.31 2.11e-7 Systemic lupus erythematosus; CESC cis rs11122272 0.701 rs743120 chr1:231531232 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC trans rs11098499 1.000 rs35643470 chr4:120184948 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.17 0.49 1.32e-17 Corneal astigmatism; CESC cis rs897984 0.683 rs72799316 chr16:30827205 A/G cg02466173 chr16:30829666 NA -0.6 -11.61 -0.58 1.8e-25 Dementia with Lewy bodies; CESC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg09323728 chr8:95962352 TP53INP1 0.36 7.02 0.4 1.88e-11 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25010622 chr20:32700257 EIF2S2 0.43 6.12 0.35 3.33e-9 Gut microbiota (bacterial taxa); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09248284 chr2:27851818 CCDC121;GPN1 -0.47 -6.61 -0.38 2.11e-10 Fibrinogen levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23975144 chr12:120875872 COX6A1 0.45 6.01 0.35 5.96e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs801193 0.904 rs4718405 chr7:66254646 A/G cg26939375 chr7:64535504 NA 0.65 8.61 0.47 6.45e-16 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15716185 chr18:60190644 ZCCHC2 -0.44 -6.39 -0.37 7.6e-10 Gambling; CESC cis rs6963495 0.818 rs114865717 chr7:105158526 C/T cg13798780 chr7:105162888 PUS7 0.78 8.04 0.44 2.99e-14 Bipolar disorder (body mass index interaction); CESC cis rs1483890 0.723 rs12629229 chr3:69411222 A/G cg22125112 chr3:69402811 FRMD4B 0.42 5.57 0.32 6.32e-8 Resting heart rate; CESC cis rs897984 0.542 rs750952 chr16:31093954 C/T cg02466173 chr16:30829666 NA -0.42 -7.21 -0.4 5.83e-12 Dementia with Lewy bodies; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07674403 chr19:13068176 GADD45GIP1 -0.61 -6.85 -0.39 5.27e-11 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05232081 chr2:10567526 HPCAL1 0.42 6.09 0.35 4e-9 Gut microbiota (bacterial taxa); CESC cis rs9457247 0.663 rs12526548 chr6:167431147 C/T cg25258033 chr6:167368657 RNASET2 0.36 5.21 0.3 3.87e-7 Crohn's disease; CESC cis rs11864453 0.614 rs12445586 chr16:72126276 C/T cg16558253 chr16:72132732 DHX38 -0.56 -8.7 -0.47 3.62e-16 Fibrinogen levels; CESC cis rs9596863 1.000 rs9316669 chr13:54401836 C/G ch.13.53330881F chr13:54432880 NA 0.65 5.45 0.32 1.13e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg10057126 chr4:77819792 ANKRD56 0.58 8.42 0.46 2.44e-15 Emphysema distribution in smoking; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16427743 chr14:65210080 PLEKHG3 -0.58 -6.72 -0.38 1.12e-10 Gut microbiome composition (summer); CESC cis rs6066835 0.572 rs11698365 chr20:47259527 C/T cg18078177 chr20:47281410 PREX1 0.68 5.06 0.3 8.03e-7 Multiple myeloma; CESC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03352830 chr11:487213 PTDSS2 0.71 7.25 0.41 4.71e-12 Body mass index; CESC cis rs35110281 0.667 rs914197 chr21:45117439 A/G cg01579765 chr21:45077557 HSF2BP -0.51 -8.35 -0.46 3.74e-15 Mean corpuscular volume; CESC cis rs7927771 0.560 rs4752858 chr11:47685829 C/T cg18512352 chr11:47633146 NA -0.36 -5.65 -0.33 4.18e-8 Subjective well-being; CESC cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg27121462 chr16:89883253 FANCA 0.41 5.08 0.3 7.04e-7 Vitiligo; CESC trans rs3749237 1.000 rs11710675 chr3:49751900 C/A cg21659725 chr3:3221576 CRBN 0.56 6.65 0.38 1.62e-10 Resting heart rate; CESC cis rs3820928 0.874 rs4675133 chr2:227843010 A/G cg11843606 chr2:227700838 RHBDD1 0.43 5.58 0.32 6e-8 Pulmonary function; CESC cis rs2637266 0.505 rs10824434 chr10:78441162 T/C cg18941641 chr10:78392320 NA -0.32 -5.19 -0.3 4.11e-7 Pulmonary function; CESC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg07870213 chr5:140052090 DND1 0.61 6.73 0.38 1.07e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs28374715 0.662 rs13329579 chr15:41467435 C/T cg18705301 chr15:41695430 NDUFAF1 -0.79 -10.4 -0.54 1.81e-21 Ulcerative colitis; CESC cis rs1559088 0.847 rs10416265 chr19:33605300 A/G cg17764715 chr19:33622953 WDR88 0.42 5.16 0.3 4.91e-7 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs34779708 0.966 rs1148245 chr10:35511894 C/T cg04310649 chr10:35416472 CREM -0.55 -6.45 -0.37 5.2e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs3768617 0.706 rs4129858 chr1:183004334 A/G ch.1.3577855R chr1:183094577 LAMC1 0.68 9.54 0.51 9.93e-19 Fuchs's corneal dystrophy; CESC cis rs4148883 0.628 rs34195655 chr4:100073795 C/T cg13256891 chr4:100009986 ADH5 0.53 7.0 0.4 2.1e-11 Alcohol dependence; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg27613076 chr10:121484944 INPP5F 0.44 6.1 0.35 3.72e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg02569458 chr12:86230093 RASSF9 0.5 7.51 0.42 9.29e-13 Major depressive disorder; CESC cis rs6500602 1.000 rs12447826 chr16:4464617 T/C cg08645402 chr16:4508243 NA 0.49 7.76 0.43 1.89e-13 Schizophrenia; CESC cis rs2302777 0.507 rs9889711 chr17:38108292 A/T cg17467752 chr17:38218738 THRA 0.41 5.11 0.3 6.17e-7 Multiple myeloma (hyperdiploidy); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02364793 chr5:175964512 RNF44 -0.44 -6.01 -0.35 6.1e-9 Asthma; CESC cis rs738322 1.000 rs4381 chr22:38570791 T/C cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg24531977 chr5:56204891 C5orf35 -0.89 -11.41 -0.57 8.38e-25 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02852436 chr20:2821472 FAM113A;VPS16 0.6 7.51 0.42 9.15e-13 Gut microbiome composition (summer); CESC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg10691866 chr7:65817282 TPST1 -0.35 -5.81 -0.34 1.82e-8 Aortic root size; CESC cis rs3820068 0.581 rs16851841 chr1:15922713 A/G cg17385448 chr1:15911702 AGMAT 0.41 6.7 0.38 1.24e-10 Systolic blood pressure; CESC trans rs629535 0.862 rs2472141 chr8:70054216 T/C cg21567404 chr3:27674614 NA 0.93 11.14 0.56 6.94e-24 Dupuytren's disease; CESC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg02807482 chr3:125708958 NA -0.39 -5.07 -0.3 7.59e-7 Blood pressure (smoking interaction); CESC cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11122272 0.735 rs2572263 chr1:231509408 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -7.82 -0.43 1.29e-13 Hemoglobin concentration; CESC cis rs4704187 0.687 rs6888707 chr5:74442920 A/G cg03227963 chr5:74354835 NA 0.3 5.58 0.32 5.99e-8 Response to amphetamines; CESC trans rs35110281 0.720 rs162393 chr21:44942692 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 7.41 0.41 1.69e-12 Mean corpuscular volume; CESC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.33 -0.41 2.74e-12 Total body bone mineral density; CESC cis rs12893668 0.637 rs12892038 chr14:104068629 G/A cg24130564 chr14:104152367 KLC1 -0.51 -6.4 -0.37 7.05e-10 Reticulocyte count; CESC cis rs208520 0.690 rs3846808 chr6:66818604 A/G cg07460842 chr6:66804631 NA -0.95 -12.85 -0.62 1.07e-29 Exhaled nitric oxide output; CESC trans rs11098499 0.820 rs11737395 chr4:120520704 C/G cg25214090 chr10:38739885 LOC399744 0.68 9.19 0.49 1.2e-17 Corneal astigmatism; CESC cis rs537626 1.000 rs537626 chr11:69307695 C/G cg08353955 chr11:69289746 NA 0.55 6.09 0.35 4.02e-9 Breast cancer (early onset); CESC cis rs11828289 0.660 rs17306433 chr11:23223034 C/G cg20040320 chr11:23191996 NA -0.68 -5.65 -0.33 4.04e-8 Cancer; CESC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg21951975 chr1:209979733 IRF6 0.61 7.52 0.42 8.54e-13 Cleft lip with or without cleft palate; CESC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg18876405 chr7:65276391 NA 0.49 6.51 0.37 3.76e-10 Aortic root size; CESC cis rs7824557 0.767 rs6985146 chr8:11170721 A/C cg21775007 chr8:11205619 TDH 0.48 6.78 0.38 7.88e-11 Retinal vascular caliber; CESC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg19163074 chr7:65112434 INTS4L2 0.4 5.07 0.3 7.58e-7 Aortic root size; CESC cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg01579765 chr21:45077557 HSF2BP -0.58 -9.96 -0.52 4.8e-20 Mean corpuscular volume; CESC cis rs2439831 0.850 rs28476182 chr15:44139643 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.46 0.42 1.21e-12 Lung cancer in ever smokers; CESC cis rs6815814 0.898 rs1873195 chr4:38891173 C/T cg02016764 chr4:38805732 TLR1 -0.57 -6.62 -0.38 2e-10 Breast cancer; CESC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg04944784 chr2:26401820 FAM59B 0.84 9.0 0.48 4.44e-17 Gut microbiome composition (summer); CESC cis rs2274273 0.870 rs946059 chr14:55847466 A/G cg04306507 chr14:55594613 LGALS3 0.31 6.09 0.35 4.04e-9 Protein biomarker; CESC cis rs9914988 0.887 rs11652710 chr17:27145075 C/T cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs9309473 0.607 rs6716776 chr2:73587713 T/C cg20560298 chr2:73613845 ALMS1 -0.44 -5.63 -0.33 4.52e-8 Metabolite levels; CESC cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs117623576 0.680 rs72777120 chr10:32367608 A/G cg03047570 chr10:32398778 NA -0.62 -6.74 -0.38 9.83e-11 Anti-saccade response; CESC cis rs7089973 0.624 rs17586888 chr10:116598121 T/C cg23260525 chr10:116636907 FAM160B1 0.4 7.38 0.41 2.03e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg26939375 chr7:64535504 NA 0.77 11.07 0.56 1.15e-23 Aortic root size; CESC cis rs6540556 0.723 rs7539852 chr1:209898539 A/G cg05527609 chr1:210001259 C1orf107 -0.56 -6.21 -0.36 2.01e-9 Red blood cell count; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02429398 chr16:53536813 AKTIP -0.42 -6.01 -0.35 6.09e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4654899 0.567 rs9426735 chr1:21505472 A/T cg05370193 chr1:21551575 ECE1 0.35 5.18 0.3 4.4e-7 Superior frontal gyrus grey matter volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08466385 chr6:18368294 NA -0.54 -6.62 -0.38 2.03e-10 Gut microbiome composition (summer); CESC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg17376030 chr22:41985996 PMM1 0.72 7.81 0.43 1.35e-13 Vitiligo; CESC cis rs965469 1.000 rs6139103 chr20:3361140 T/C cg25506879 chr20:3388711 C20orf194 -0.57 -6.01 -0.35 6.27e-9 IFN-related cytopenia; CESC cis rs7312933 0.501 rs3810793 chr12:42729407 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.47 5.84 0.34 1.54e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs897984 0.684 rs6950 chr16:30995669 T/C cg02466173 chr16:30829666 NA 0.48 8.09 0.44 2.18e-14 Dementia with Lewy bodies; CESC cis rs9915657 0.773 rs9912974 chr17:70095963 C/T cg09344028 chr17:70110421 NA 0.41 8.29 0.45 5.69e-15 Thyroid hormone levels; CESC cis rs12477438 0.520 rs1133978 chr2:99741964 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.63 0.61 6.22e-29 Chronic sinus infection; CESC cis rs752010 0.619 rs6702659 chr1:42112236 T/C cg06885757 chr1:42089581 HIVEP3 0.65 10.05 0.53 2.44e-20 Lupus nephritis in systemic lupus erythematosus; CESC cis rs6732160 0.588 rs62151795 chr2:73376840 G/A cg01422370 chr2:73384389 NA 0.57 9.17 0.49 1.4e-17 Intelligence (multi-trait analysis); CESC cis rs4909189 1.000 rs62493650 chr7:158135570 G/T cg06219351 chr7:158114137 PTPRN2 -0.6 -8.1 -0.45 2e-14 Response to amphetamines; CESC cis rs6460942 0.591 rs80311633 chr7:12339690 G/C cg20607287 chr7:12443886 VWDE -0.61 -6.7 -0.38 1.24e-10 Coronary artery disease; CESC cis rs9486719 1.000 rs2472880 chr6:96860130 G/A cg06623918 chr6:96969491 KIAA0776 0.81 8.08 0.44 2.38e-14 Migraine;Coronary artery disease; CESC cis rs55728055 1.000 rs8142355 chr22:32081681 C/T cg01338084 chr22:32026380 PISD 1.25 8.17 0.45 1.31e-14 Age-related hearing impairment; CESC cis rs11690935 0.550 rs62183785 chr2:172866976 G/A cg13550731 chr2:172543902 DYNC1I2 0.49 6.75 0.38 9.18e-11 Schizophrenia; CESC cis rs9660992 0.762 rs1668871 chr1:205237137 T/C cg21643547 chr1:205240462 TMCC2 -0.46 -6.7 -0.38 1.22e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg18904891 chr8:8559673 CLDN23 0.66 7.63 0.42 4.23e-13 Obesity-related traits; CESC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg18099408 chr3:52552593 STAB1 -0.44 -8.37 -0.46 3.28e-15 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01505312 chr11:56258856 OR5M8;OR8U8 -0.43 -6.44 -0.37 5.74e-10 Gut microbiome composition (summer); CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg25270252 chr3:130745615 NEK11;ASTE1 0.48 6.28 0.36 1.36e-9 Tetralogy of Fallot; CESC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg11168104 chr5:1857477 NA -0.37 -5.38 -0.31 1.62e-7 Cardiovascular disease risk factors; CESC cis rs67311347 0.956 rs7640228 chr3:40516190 G/A cg24209194 chr3:40518798 ZNF619 -0.53 -6.87 -0.39 4.67e-11 Renal cell carcinoma; CESC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg21285383 chr16:89894308 SPIRE2 0.32 5.89 0.34 1.18e-8 Vitiligo; CESC trans rs4662834 0.872 rs12996713 chr2:129483106 A/G cg12497543 chr10:97515377 ENTPD1 -0.38 -6.32 -0.36 1.08e-9 Response to bleomycin (chromatid breaks); CESC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg23758822 chr17:41437982 NA 1.03 15.5 0.69 5.3e-39 Menopause (age at onset); CESC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg08704250 chr15:31115839 NA -0.63 -8.2 -0.45 1.05e-14 Huntington's disease progression; CESC cis rs8002861 0.905 rs12853286 chr13:44446817 A/G cg19180546 chr13:44453867 C13orf31;CCDC122 -0.48 -5.98 -0.34 7.07e-9 Leprosy; CESC trans rs11098499 0.955 rs35434465 chr4:120169378 C/G cg25214090 chr10:38739885 LOC399744 0.62 8.25 0.45 7.27e-15 Corneal astigmatism; CESC cis rs8180040 0.701 rs62248439 chr3:46996448 A/G cg27129171 chr3:47204927 SETD2 -0.64 -9.06 -0.49 2.9e-17 Colorectal cancer; CESC cis rs11648796 0.757 rs6600231 chr16:766485 A/G cg27144592 chr16:783916 NARFL -0.44 -6.27 -0.36 1.44e-9 Height; CESC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.77 10.11 0.53 1.56e-20 Height; CESC cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg17143192 chr8:8559678 CLDN23 -0.46 -5.49 -0.32 9.49e-8 Mood instability; CESC cis rs7680126 0.596 rs11722185 chr4:10317482 C/G cg11266682 chr4:10021025 SLC2A9 -0.41 -5.38 -0.31 1.64e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12771118 chr3:138067402 MRAS -0.49 -6.36 -0.36 8.79e-10 Asthma; CESC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg06456125 chr7:65229604 NA -0.4 -5.59 -0.32 5.76e-8 Aortic root size; CESC cis rs2066819 1.000 rs76466034 chr12:56719450 G/A cg26734620 chr12:56694298 CS 1.03 6.25 0.36 1.65e-9 Psoriasis vulgaris; CESC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg10691866 chr7:65817282 TPST1 0.34 5.75 0.33 2.42e-8 Aortic root size; CESC cis rs9287719 0.578 rs7598541 chr2:10700516 G/A cg00105475 chr2:10696890 NA 0.41 5.65 0.33 4.24e-8 Prostate cancer; CESC cis rs6547741 0.967 rs4665999 chr2:27834444 T/C cg21248554 chr2:27665150 KRTCAP3 0.24 5.09 0.3 6.94e-7 Oral cavity cancer; CESC cis rs7917772 0.636 rs7911747 chr10:104528890 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.45 -5.29 -0.31 2.59e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs738322 0.839 rs133015 chr22:38572526 C/G cg17652424 chr22:38574118 PLA2G6 -0.34 -5.87 -0.34 1.29e-8 Cutaneous nevi; CESC cis rs7107174 1.000 rs2510039 chr11:77944480 G/A cg02023728 chr11:77925099 USP35 0.55 6.87 0.39 4.69e-11 Testicular germ cell tumor; CESC cis rs7918232 0.607 rs1755401 chr10:27405763 A/C cg14442939 chr10:27389572 ANKRD26 0.68 5.2 0.3 3.93e-7 Breast cancer; CESC cis rs3091242 0.728 rs706845 chr1:25730713 G/A cg02931644 chr1:25747376 RHCE 0.38 6.24 0.36 1.7e-9 Erythrocyte sedimentation rate; CESC cis rs6728642 0.908 rs6731522 chr2:97647997 A/G cg26665480 chr2:98280029 ACTR1B -0.71 -7.64 -0.42 4.04e-13 Bipolar disorder lithium response (continuous) or schizophrenia; CESC cis rs710216 0.843 rs710214 chr1:43439282 C/T cg22176566 chr1:43424700 SLC2A1 0.47 5.12 0.3 5.98e-7 Red cell distribution width; CESC cis rs2635047 1.000 rs2277717 chr18:44702718 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 6.81 0.39 6.52e-11 Educational attainment; CESC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.46 -6.36 -0.36 8.6e-10 Bipolar disorder; CESC cis rs2108622 0.727 rs12609468 chr19:15977814 A/G cg13772218 chr19:15982569 NA 0.29 5.69 0.33 3.28e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg10523679 chr1:76189770 ACADM 0.68 6.63 0.38 1.86e-10 Blood metabolite levels;Acylcarnitine levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04650786 chr6:108395545 OSTM1 0.47 6.13 0.35 3.25e-9 Systemic lupus erythematosus; CESC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs11630290 0.592 rs12594446 chr15:64156674 G/T cg12036633 chr15:63758958 NA 0.45 5.46 0.32 1.12e-7 Iris characteristics; CESC cis rs7918232 0.941 rs10741128 chr10:27411509 G/A cg14442939 chr10:27389572 ANKRD26 0.68 6.73 0.38 1.04e-10 Breast cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07899956 chr17:74261249 FAM100B 0.45 6.54 0.37 3.19e-10 Gut microbiota (bacterial taxa); CESC cis rs6674176 0.597 rs6671164 chr1:44403489 G/T cg12908607 chr1:44402522 ARTN -0.49 -7.33 -0.41 2.84e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7077164 0.607 rs1227771 chr10:71577902 C/T cg07630274 chr10:71583235 COL13A1 -0.33 -5.93 -0.34 9.17e-9 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs8058578 0.832 rs3812999 chr16:30773605 G/T cg00531865 chr16:30841666 NA -0.46 -6.22 -0.36 1.94e-9 Multiple myeloma; CESC trans rs561341 0.941 rs2470236 chr17:30304940 G/C cg27661571 chr11:113659931 NA -0.72 -7.45 -0.42 1.31e-12 Hip circumference adjusted for BMI; CESC cis rs5750830 0.594 rs9611166 chr22:39775268 T/C cg24399712 chr22:39784796 NA -0.77 -11.05 -0.56 1.34e-23 Intelligence (multi-trait analysis); CESC cis rs2749592 0.550 rs7081464 chr10:37883937 C/T cg00409905 chr10:38381863 ZNF37A 0.41 5.36 0.31 1.85e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs17826219 0.561 rs4085382 chr17:29071202 T/C cg19761014 chr17:28927070 LRRC37B2 0.72 6.21 0.36 2.07e-9 Body mass index; CESC cis rs67460515 0.563 rs6441362 chr3:160877613 G/A cg03342759 chr3:160939853 NMD3 -0.49 -6.36 -0.36 8.8e-10 Parkinson's disease; CESC cis rs7605827 0.930 rs10929374 chr2:15676884 T/A cg19274914 chr2:15703543 NA 0.3 5.39 0.31 1.57e-7 Educational attainment (years of education); CESC cis rs2797160 1.000 rs13328298 chr6:126016580 G/A cg05901451 chr6:126070800 HEY2 0.46 6.63 0.38 1.86e-10 Endometrial cancer; CESC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg24642844 chr7:1081250 C7orf50 -0.64 -8.58 -0.47 8.21e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6582630 0.502 rs11520276 chr12:38359216 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.81 0.55 8.31e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs698833 0.828 rs786623 chr2:44606171 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.45 5.74 0.33 2.64e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs17401966 1.000 rs6700866 chr1:10306038 A/G cg15208524 chr1:10270712 KIF1B 0.43 5.8 0.34 1.93e-8 Hepatocellular carcinoma; CESC cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg22467129 chr15:76604101 ETFA -0.35 -5.25 -0.31 3.16e-7 Blood metabolite levels; CESC cis rs7678296 1.000 rs1342999 chr4:37217990 A/G cg06805348 chr4:37245195 KIAA1239 0.47 5.2 0.3 4.07e-7 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs2073300 0.609 rs6137914 chr20:23358364 C/T cg16736954 chr20:23401023 NAPB 0.8 6.09 0.35 3.89e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg16339924 chr4:17578868 LAP3 0.66 8.38 0.46 3.23e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg00129232 chr17:37814104 STARD3 0.54 7.03 0.4 1.75e-11 Glomerular filtration rate (creatinine); CESC cis rs8067545 0.611 rs2703771 chr17:20130154 C/G cg13482628 chr17:19912719 NA -0.42 -5.59 -0.33 5.51e-8 Schizophrenia; CESC cis rs7647973 0.710 rs2029591 chr3:49646981 C/T cg07636037 chr3:49044803 WDR6 -0.57 -6.59 -0.38 2.31e-10 Menarche (age at onset); CESC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg05340658 chr4:99064831 C4orf37 0.83 13.1 0.63 1.43e-30 Colonoscopy-negative controls vs population controls; CESC trans rs2219968 0.683 rs4607596 chr8:78902651 C/T cg23454517 chr17:77917772 TBC1D16 0.38 6.02 0.35 5.64e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2243480 0.901 rs2900904 chr7:65204264 C/G cg25894440 chr7:65020034 NA -0.66 -5.49 -0.32 9.63e-8 Diabetic kidney disease; CESC cis rs7188697 0.922 rs2090727 chr16:58604161 A/G cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.51 -6.6 -0.38 2.17e-10 Bipolar disorder; CESC cis rs11264213 0.901 rs72661646 chr1:36454954 A/T cg27506609 chr1:36549197 TEKT2 0.67 5.56 0.32 6.59e-8 Schizophrenia; CESC cis rs10206020 0.921 rs72778009 chr2:1573322 G/T cg12573674 chr2:1569213 NA -0.48 -5.48 -0.32 9.85e-8 IgG glycosylation; CESC cis rs3845702 0.673 rs12468986 chr2:180862320 T/G cg01881094 chr2:180872142 CWC22 1.08 9.4 0.5 2.75e-18 Schizophrenia; CESC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -7.96 -0.44 5.04e-14 Personality dimensions; CESC cis rs9790314 1.000 rs1382426 chr3:161045933 G/A cg04691961 chr3:161091175 C3orf57 -0.42 -5.31 -0.31 2.3e-7 Morning vs. evening chronotype; CESC cis rs929354 0.772 rs2051876 chr7:157009037 A/G cg05182265 chr7:156933206 UBE3C 0.46 6.78 0.38 7.7e-11 Body mass index; CESC cis rs56104184 0.775 rs73061694 chr19:49399978 T/C cg21252483 chr19:49399788 TULP2 -0.52 -5.69 -0.33 3.36e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs7662987 0.540 rs2851257 chr4:100039499 G/C cg13256891 chr4:100009986 ADH5 0.75 8.03 0.44 3.29e-14 Smoking initiation; CESC cis rs9660992 0.626 rs61823972 chr1:205201325 A/C cg00857998 chr1:205179979 DSTYK 0.51 6.65 0.38 1.69e-10 Mean corpuscular volume;Mean platelet volume; CESC trans rs6951245 0.744 rs1133122 chr7:1192572 C/A cg13565492 chr6:43139072 SRF -0.61 -6.23 -0.36 1.79e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg05896524 chr21:47604654 C21orf56 0.43 5.57 0.32 6.11e-8 Testicular germ cell tumor; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22218536 chr3:40518595 ZNF619 -0.41 -6.09 -0.35 3.9e-9 Gambling; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11911399 chr1:108742837 SLC25A24 0.56 6.49 0.37 4.12e-10 Gut microbiome composition (summer); CESC cis rs73206853 0.688 rs57837519 chr12:110961082 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.8 0.34 1.91e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg26668713 chr11:65405903 SIPA1 0.71 7.8 0.43 1.39e-13 Blood pressure (age interaction); CESC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg22143856 chr6:28129313 ZNF389 0.46 5.83 0.34 1.58e-8 Depression; CESC cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg05457628 chr5:178986728 RUFY1 0.49 7.04 0.4 1.68e-11 Lung cancer; CESC cis rs78366141 0.649 rs112818517 chr4:89653103 G/A cg01026744 chr4:89619053 NAP1L5;HERC3 0.88 5.86 0.34 1.34e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs2055729 0.500 rs1396186 chr8:9875204 T/C cg21625330 chr8:9911636 MSRA -0.51 -5.26 -0.31 2.92e-7 Multiple myeloma (hyperdiploidy); CESC cis rs7998202 0.667 rs665813 chr13:113355765 A/G cg02820901 chr13:113351484 ATP11A 0.64 5.7 0.33 3.25e-8 Glycated hemoglobin levels; CESC cis rs4700695 0.719 rs27588 chr5:65459360 C/A cg21114390 chr5:65439923 SFRS12 -0.49 -5.98 -0.34 7.35e-9 Facial morphology (factor 19); CESC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg12463550 chr7:65579703 CRCP -0.57 -7.4 -0.41 1.79e-12 Aortic root size; CESC cis rs36051895 0.632 rs117896567 chr9:5141281 C/G cg02405213 chr9:5042618 JAK2 -0.5 -6.02 -0.35 5.93e-9 Pediatric autoimmune diseases; CESC cis rs2625529 0.824 rs7182776 chr15:72462831 A/G cg16672083 chr15:72433130 SENP8 0.41 5.82 0.34 1.66e-8 Red blood cell count; CESC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC trans rs61931739 0.534 rs7310499 chr12:34212112 G/A cg26384229 chr12:38710491 ALG10B 0.65 9.28 0.5 6.46e-18 Morning vs. evening chronotype; CESC cis rs9300255 0.602 rs1727315 chr12:123638930 A/G cg05973401 chr12:123451056 ABCB9 -0.51 -5.85 -0.34 1.46e-8 Neutrophil percentage of white cells; CESC cis rs213032 1.000 rs213027 chr1:21651660 G/T cg16416158 chr1:21652298 ECE1 0.33 5.48 0.32 9.99e-8 Obesity-related traits; CESC trans rs11098499 0.697 rs6832410 chr4:120296800 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg07701084 chr6:150067640 NUP43 0.43 5.85 0.34 1.45e-8 Lung cancer; CESC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg21770322 chr7:97807741 LMTK2 0.56 8.55 0.47 9.65e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg19539972 chr4:7069911 GRPEL1 0.78 9.98 0.52 3.98e-20 Monocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25503565 chr17:38264529 NA 0.55 6.26 0.36 1.54e-9 Gut microbiome composition (summer); CESC cis rs713587 1.000 rs2384054 chr2:25156773 T/C cg01884057 chr2:25150051 NA 0.43 8.06 0.44 2.71e-14 Body mass index in non-asthmatics; CESC cis rs67460515 0.892 rs1478566 chr3:161030335 A/T cg03342759 chr3:160939853 NMD3 -0.54 -7.68 -0.43 3.01e-13 Parkinson's disease; CESC cis rs965469 1.000 rs6037532 chr20:3267911 T/C cg25506879 chr20:3388711 C20orf194 -0.55 -5.96 -0.34 7.97e-9 IFN-related cytopenia; CESC cis rs4604732 0.631 rs10925043 chr1:247627001 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7937682 0.889 rs551825 chr11:111480116 C/G cg22437258 chr11:111473054 SIK2 0.72 9.69 0.51 3.38e-19 Primary sclerosing cholangitis; CESC cis rs73206853 0.925 rs61106808 chr12:110876009 C/G cg12870014 chr12:110450643 ANKRD13A 0.66 5.9 0.34 1.13e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg25427524 chr10:38739819 LOC399744 -0.71 -10.71 -0.55 1.78e-22 Extrinsic epigenetic age acceleration; CESC cis rs9300255 0.544 rs1716175 chr12:123658388 A/T cg19016782 chr12:123741754 C12orf65 -0.43 -5.89 -0.34 1.16e-8 Neutrophil percentage of white cells; CESC cis rs9611565 0.649 rs5758466 chr22:42176059 G/A cg06481639 chr22:41940642 POLR3H 0.47 5.28 0.31 2.67e-7 Vitiligo; CESC cis rs1055129 0.537 rs1135640 chr17:73949540 C/G cg08125733 chr17:73851984 WBP2 -0.49 -6.63 -0.38 1.86e-10 White matter hyperintensity burden; CESC cis rs9929218 0.559 rs11642362 chr16:68811307 T/C cg02972257 chr16:68554789 NA -0.42 -5.26 -0.31 2.92e-7 Colorectal cancer; CESC cis rs910316 0.967 rs1071989 chr14:75564659 G/T cg08847533 chr14:75593920 NEK9 0.99 18.74 0.75 1.84e-50 Height; CESC cis rs35306767 0.903 rs12778891 chr10:950130 T/A cg20503657 chr10:835505 NA 0.82 8.4 0.46 2.81e-15 Eosinophil percentage of granulocytes; CESC cis rs4595586 0.545 rs12816776 chr12:39375817 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC trans rs7839040 0.698 rs10106364 chr8:82920659 A/G cg14472086 chr9:107730925 NA -0.46 -6.29 -0.36 1.29e-9 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs523522 0.962 rs12309824 chr12:120990582 A/C cg12219531 chr12:120966889 COQ5 0.74 9.75 0.51 2.17e-19 High light scatter reticulocyte count; CESC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg24829409 chr8:58192753 C8orf71 -0.69 -7.68 -0.43 3.13e-13 Developmental language disorder (linguistic errors); CESC cis rs17666538 0.535 rs896522 chr8:616991 A/G cg07234876 chr8:600039 NA 0.84 5.94 0.34 9.04e-9 IgG glycosylation; CESC cis rs2832191 0.740 rs2012645 chr21:30445961 G/A cg24692254 chr21:30365293 RNF160 0.99 17.29 0.73 2.32e-45 Dental caries; CESC cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg03709012 chr19:19516395 GATAD2A 0.99 15.8 0.7 4.37e-40 Tonsillectomy; CESC cis rs2985684 1.000 rs7142457 chr14:50097862 C/T cg02151108 chr14:50098012 C14orf104 -0.42 -5.48 -0.32 9.97e-8 Carotid intima media thickness; CESC cis rs1790761 0.692 rs611663 chr11:67312221 C/T cg08355456 chr11:67383691 NA 0.33 5.15 0.3 5.01e-7 Mean corpuscular volume; CESC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg17724175 chr1:150552817 MCL1 0.41 6.16 0.35 2.64e-9 Melanoma; CESC trans rs9929218 0.953 rs11075696 chr16:68731365 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -10.56 -0.54 5.67e-22 Colorectal cancer; CESC cis rs920590 0.684 rs57462676 chr8:19670848 G/C cg01411142 chr8:19674711 INTS10 0.5 5.44 0.32 1.19e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs654950 0.792 rs625448 chr1:41988541 A/T cg06885757 chr1:42089581 HIVEP3 0.4 6.29 0.36 1.34e-9 Airway imaging phenotypes; CESC cis rs6088590 0.901 rs6087631 chr20:33403509 T/C cg08999081 chr20:33150536 PIGU 0.58 8.88 0.48 1.04e-16 Coronary artery disease; CESC cis rs2430307 0.556 rs3905501 chr7:76542080 C/T cg15770687 chr7:76625569 PMS2L11 -0.53 -5.31 -0.31 2.37e-7 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg02725872 chr8:58115012 NA -0.44 -6.1 -0.35 3.84e-9 Developmental language disorder (linguistic errors); CESC cis rs11031096 0.621 rs11031159 chr11:4179695 T/G cg18678763 chr11:4115507 RRM1 -0.46 -6.24 -0.36 1.76e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs854765 0.547 rs9912096 chr17:17896673 A/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.53 7.06 0.4 1.46e-11 Total body bone mineral density; CESC cis rs2963155 0.518 rs865482 chr5:142640317 C/A cg17617527 chr5:142782415 NR3C1 0.84 7.16 0.4 7.87e-12 Breast cancer; CESC cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg21699342 chr2:239360505 ASB1 0.41 5.72 0.33 2.92e-8 Multiple system atrophy; CESC cis rs4803468 1.000 rs11670668 chr19:41920454 G/C cg14132834 chr19:41945861 ATP5SL -0.67 -8.23 -0.45 8.57e-15 Height; CESC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg04267008 chr7:1944627 MAD1L1 -0.53 -6.38 -0.36 8e-10 Bipolar disorder and schizophrenia; CESC cis rs5758511 0.680 rs5758699 chr22:42688034 C/G cg00645731 chr22:42541494 CYP2D7P1 0.54 8.23 0.45 8.4e-15 Birth weight; CESC cis rs6752107 0.936 rs1045100 chr2:234203597 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.65 0.38 1.7e-10 Crohn's disease;Inflammatory bowel disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg25425078 chr12:4381777 CCND2 -0.49 -7.34 -0.41 2.68e-12 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.31 0.31 2.36e-7 Colonoscopy-negative controls vs population controls; CESC cis rs470119 1.000 rs2782 chr22:50961854 T/C cg12969734 chr22:50962224 SCO2 0.41 6.29 0.36 1.32e-9 Mean corpuscular hemoglobin; CESC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg18446336 chr7:2847575 GNA12 -0.38 -5.8 -0.34 1.9e-8 Height; CESC cis rs1267303 0.642 rs7542296 chr1:46998009 A/G cg25110126 chr1:46999211 NA 0.97 12.5 0.61 1.7e-28 Monobrow; CESC cis rs12479064 0.724 rs112900993 chr2:99948805 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -7.2 -0.4 6.39e-12 Chronic sinus infection; CESC cis rs4704187 0.663 rs7735057 chr5:74403857 T/A cg03227963 chr5:74354835 NA 0.32 5.94 0.34 8.7e-9 Response to amphetamines; CESC cis rs12497850 0.931 rs11920534 chr3:48937761 G/T cg02487422 chr3:49467188 NICN1 0.38 5.04 0.3 8.65e-7 Parkinson's disease; CESC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.42 -5.35 -0.31 1.91e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg17949981 chr6:28129498 ZNF389 0.39 5.1 0.3 6.36e-7 Parkinson's disease; CESC cis rs10751667 0.666 rs7483273 chr11:951127 T/C cg06064525 chr11:970664 AP2A2 -0.47 -9.17 -0.49 1.33e-17 Alzheimer's disease (late onset); CESC cis rs1364705 0.910 rs13274578 chr8:120314864 T/C cg09273054 chr8:120220131 MAL2 0.63 7.1 0.4 1.15e-11 Hippocampal atrophy; CESC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg19163074 chr7:65112434 INTS4L2 0.51 5.33 0.31 2.12e-7 Aortic root size; CESC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg22903471 chr2:27725779 GCKR -0.5 -7.38 -0.41 2.04e-12 Total body bone mineral density; CESC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg24846343 chr22:24311635 DDTL 0.66 11.37 0.57 1.2e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9931543 0.504 rs4784651 chr16:56311774 A/G cg02433656 chr16:56322654 GNAO1 -0.4 -5.29 -0.31 2.54e-7 Subjective well-being; CESC cis rs34638657 0.732 rs4889477 chr16:82201302 C/T cg09439754 chr16:82129088 HSD17B2 -0.36 -6.24 -0.36 1.71e-9 Lung adenocarcinoma; CESC cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.99 0.35 6.71e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2120019 0.938 rs1867150 chr15:75321139 T/C cg09165964 chr15:75287851 SCAMP5 -0.81 -10.13 -0.53 1.34e-20 Blood trace element (Zn levels); CESC cis rs1728785 1.000 rs1645927 chr16:68589300 T/G cg02972257 chr16:68554789 NA -0.59 -6.79 -0.38 7.32e-11 Ulcerative colitis; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12475106 chr4:503275 PIGG -0.48 -6.17 -0.35 2.61e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs34779708 0.966 rs12260130 chr10:35467671 C/T cg03585969 chr10:35415529 CREM 0.77 10.56 0.54 5.56e-22 Inflammatory bowel disease;Crohn's disease; CESC cis rs1371867 0.817 rs1788185 chr8:101335529 T/C cg11906718 chr8:101322791 RNF19A 0.53 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC cis rs2839186 0.504 rs4347941 chr21:47938239 T/C cg10657630 chr21:48055338 PRMT2 0.45 5.69 0.33 3.38e-8 Testicular germ cell tumor; CESC cis rs2486288 0.656 rs2413773 chr15:45549442 C/A cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs3733585 0.660 rs13122290 chr4:9933832 A/G cg02734326 chr4:10020555 SLC2A9 -0.41 -5.99 -0.35 6.74e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7586673 0.893 rs889925 chr2:161971597 T/C cg21518248 chr2:162101506 NA 0.46 6.24 0.36 1.73e-9 Intelligence (multi-trait analysis); CESC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg12648201 chr2:27665141 KRTCAP3 0.36 6.94 0.39 3.07e-11 Total body bone mineral density; CESC cis rs9309473 0.950 rs6740766 chr2:73780913 A/G cg20560298 chr2:73613845 ALMS1 -0.54 -7.08 -0.4 1.31e-11 Metabolite levels; CESC cis rs3750082 0.852 rs7786669 chr7:32898338 A/G cg08946731 chr7:32981826 RP9P 0.35 5.04 0.3 8.55e-7 Glomerular filtration rate (creatinine); CESC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg25405998 chr7:65216604 CCT6P1 0.48 5.57 0.32 6.4e-8 Aortic root size; CESC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg18404041 chr3:52824283 ITIH1 -0.41 -6.77 -0.38 8.16e-11 Bipolar disorder; CESC cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg10523679 chr1:76189770 ACADM 0.76 10.05 0.53 2.4e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg27170947 chr2:26402098 FAM59B -0.59 -7.05 -0.4 1.59e-11 Gut microbiome composition (summer); CESC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg27286337 chr10:134555280 INPP5A 0.69 8.04 0.44 2.95e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg05347473 chr6:146136440 FBXO30 0.59 7.78 0.43 1.59e-13 Lobe attachment (rater-scored or self-reported); CESC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg03395511 chr6:291903 DUSP22 0.7 9.0 0.48 4.55e-17 Menopause (age at onset); CESC cis rs7107174 1.000 rs2511178 chr11:77923220 C/T cg02023728 chr11:77925099 USP35 0.49 6.56 0.37 2.89e-10 Testicular germ cell tumor; CESC cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg23048001 chr7:2026167 MAD1L1 0.45 5.79 0.33 2.01e-8 Schizophrenia; CESC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg13206674 chr6:150067644 NUP43 0.4 5.43 0.32 1.25e-7 Lung cancer; CESC cis rs6502050 0.805 rs6502057 chr17:80082060 A/G cg11859384 chr17:80120422 CCDC57 0.37 5.12 0.3 5.88e-7 Life satisfaction; CESC cis rs9303401 0.659 rs16943326 chr17:57050365 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.0 12.47 0.61 2.1e-28 Cognitive test performance; CESC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg04944784 chr2:26401820 FAM59B -0.91 -10.38 -0.54 2.12e-21 Gut microbiome composition (summer); CESC cis rs2637266 0.935 rs2579719 chr10:78400026 A/G cg18941641 chr10:78392320 NA 0.45 8.65 0.47 5e-16 Pulmonary function; CESC cis rs12325245 0.536 rs12931124 chr16:58620063 G/A cg05725404 chr16:58534157 NDRG4 -0.64 -5.37 -0.31 1.76e-7 Schizophrenia; CESC cis rs2204008 0.640 rs11520199 chr12:38211026 T/C cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs3780486 0.846 rs2209948 chr9:33138247 G/A cg13443165 chr9:33130375 B4GALT1 0.45 6.49 0.37 4.1e-10 IgG glycosylation; CESC trans rs7090925 1.000 rs2646424 chr10:8463115 G/C cg02275004 chr12:976007 WNK1;HSN2 0.46 6.04 0.35 5.17e-9 Systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11993436 chr7:155437098 RBM33 0.51 6.07 0.35 4.39e-9 Gut microbiome composition (summer); CESC cis rs1355223 0.506 rs7947848 chr11:34866220 T/C cg11622362 chr11:34938112 PDHX;APIP 0.44 5.29 0.31 2.52e-7 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -7.56 -0.42 6.46e-13 Tonsillectomy; CESC cis rs977987 0.843 rs60730309 chr16:75431769 C/G cg03315344 chr16:75512273 CHST6 0.39 5.71 0.33 2.98e-8 Dupuytren's disease; CESC cis rs2735413 0.875 rs4888737 chr16:78083819 A/G cg04733911 chr16:78082701 NA -0.53 -8.89 -0.48 9.44e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs11655198 1 rs11655198 chr17:38026169 C/T cg20243544 chr17:37824526 PNMT 0.53 7.05 0.4 1.57e-11 Asthma; CESC cis rs9611565 0.592 rs5751139 chr22:42099981 G/C cg03806693 chr22:41940476 POLR3H 1.15 13.67 0.64 1.42e-32 Vitiligo; CESC cis rs1878931 0.668 rs11643983 chr16:3438865 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 1.02 17.06 0.72 1.5e-44 Body mass index (adult); CESC cis rs9303401 0.659 rs12946852 chr17:57013337 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.98 11.93 0.59 1.56e-26 Cognitive test performance; CESC cis rs7605827 0.930 rs2241236 chr2:15655480 A/G cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.65e-10 Educational attainment (years of education); CESC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg18016565 chr1:150552671 MCL1 0.35 5.36 0.31 1.86e-7 Tonsillectomy; CESC cis rs7666738 0.830 rs11729753 chr4:98803267 T/A cg03467027 chr4:99064603 C4orf37 0.44 5.43 0.32 1.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs9457247 1.000 rs430477 chr6:167389851 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC cis rs9660180 0.620 rs34298494 chr1:1663402 A/C cg27541892 chr1:1571801 CDK11B -0.61 -8.05 -0.44 2.83e-14 Body mass index; CESC cis rs4843747 0.605 rs28399183 chr16:88107277 G/A cg06915872 chr16:87998081 BANP 0.44 5.31 0.31 2.32e-7 Menopause (age at onset); CESC cis rs6500395 1.000 rs7191028 chr16:48626023 T/C cg04672837 chr16:48644449 N4BP1 0.53 6.65 0.38 1.63e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg06697600 chr4:7070879 GRPEL1 0.52 6.07 0.35 4.51e-9 Monocyte percentage of white cells; CESC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.66 -8.82 -0.48 1.54e-16 Prudent dietary pattern; CESC cis rs2425143 0.818 rs35448195 chr20:34542365 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.59 0.32 5.74e-8 Blood protein levels; CESC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg07395648 chr5:131743802 NA -0.45 -5.68 -0.33 3.61e-8 Breast cancer;Mosquito bite size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15097968 chr15:63449935 RPS27L -0.49 -7.01 -0.4 1.93e-11 Gambling; CESC cis rs9487051 0.714 rs9487058 chr6:109631060 A/C cg01475377 chr6:109611718 NA -0.46 -7.2 -0.4 6.15e-12 Reticulocyte fraction of red cells; CESC cis rs9325144 0.532 rs1352121 chr12:39130696 A/G cg26384229 chr12:38710491 ALG10B -0.51 -7.05 -0.4 1.58e-11 Morning vs. evening chronotype; CESC trans rs941207 0.542 rs7311381 chr12:57194070 G/A cg26462586 chr2:11164677 NA 0.38 6.1 0.35 3.74e-9 Platelet count; CESC cis rs6967414 0.786 rs3757482 chr7:6748927 A/G cg00387323 chr7:6746715 ZNF12 0.66 6.25 0.36 1.65e-9 Hematocrit;Hemoglobin concentration; CESC trans rs61931739 0.500 rs11053212 chr12:34466116 T/G cg13010199 chr12:38710504 ALG10B 0.49 6.29 0.36 1.3e-9 Morning vs. evening chronotype; CESC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg26354017 chr1:205819088 PM20D1 0.84 13.04 0.63 2.31e-30 Menarche (age at onset); CESC cis rs1256061 0.603 rs1256041 chr14:64738029 A/G cg23250157 chr14:64679961 SYNE2 0.53 7.64 0.42 4.09e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2243480 0.901 rs778693 chr7:65872345 T/G cg18252515 chr7:66147081 NA -1.39 -14.18 -0.66 2.5e-34 Diabetic kidney disease; CESC cis rs2299587 0.604 rs11203933 chr8:17901910 G/T cg18067069 chr8:17937731 ASAH1 -0.37 -5.09 -0.3 6.95e-7 Economic and political preferences; CESC trans rs2908835 0.705 rs12425902 chr12:11643114 T/C cg09915232 chr8:1879280 ARHGEF10 -0.64 -6.29 -0.36 1.31e-9 Information processing speed; CESC cis rs2777491 0.957 rs8027626 chr15:41711514 T/G cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.76 -0.51 1.95e-19 Ulcerative colitis; CESC cis rs7953249 0.656 rs2243616 chr12:121406370 G/T cg02403541 chr12:121454288 C12orf43 -0.55 -7.05 -0.4 1.52e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.91 10.16 0.53 1.07e-20 Platelet count; CESC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg12718519 chr1:2058417 PRKCZ -0.24 -5.2 -0.3 4e-7 Height; CESC cis rs6460942 0.915 rs72584550 chr7:12304990 G/A cg20607287 chr7:12443886 VWDE -0.42 -5.92 -0.34 1.02e-8 Coronary artery disease; CESC cis rs8067354 0.645 rs7215180 chr17:57822354 A/G cg02344993 chr17:57696989 CLTC 0.68 8.07 0.44 2.5e-14 Hemoglobin concentration; CESC cis rs8114671 0.562 rs6119545 chr20:33522869 T/C cg24642439 chr20:33292090 TP53INP2 0.43 5.19 0.3 4.19e-7 Height; CESC cis rs7216064 1.000 rs2365468 chr17:65841318 C/T cg12091567 chr17:66097778 LOC651250 -0.81 -9.35 -0.5 3.74e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26934072 chr16:2033910 GFER 0.53 6.39 0.37 7.37e-10 Gut microbiome composition (summer); CESC cis rs10771431 1.000 rs11611670 chr12:9385535 C/T cg08997352 chr12:9597637 DDX12 -0.66 -8.78 -0.47 2.07e-16 Breast size; CESC cis rs10129255 0.518 rs10150460 chr14:107133196 C/G cg23076370 chr14:107095027 NA 0.63 9.86 0.52 9.63e-20 Kawasaki disease; CESC cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg16339924 chr4:17578868 LAP3 0.61 7.58 0.42 5.98e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9910055 0.664 rs433610 chr17:42197281 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.43 -6.34 -0.36 9.82e-10 Total body bone mineral density; CESC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg07701084 chr6:150067640 NUP43 0.44 6.12 0.35 3.33e-9 Lung cancer; CESC cis rs11809207 0.574 rs2783631 chr1:26504756 C/T cg00147160 chr1:26503991 CNKSR1 0.27 5.16 0.3 4.81e-7 Height; CESC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg14393609 chr7:65229607 NA -0.42 -5.86 -0.34 1.35e-8 Aortic root size; CESC cis rs939658 0.805 rs35462901 chr15:79442201 C/T cg17916960 chr15:79447300 NA -0.35 -5.98 -0.34 7.25e-9 Refractive error; CESC cis rs9549367 0.789 rs9577218 chr13:113894911 A/G cg00898013 chr13:113819073 PROZ -0.53 -7.54 -0.42 7.53e-13 Platelet distribution width; CESC cis rs3105593 0.965 rs8029073 chr15:50913148 T/A cg08437265 chr15:50716283 USP8 0.4 5.12 0.3 6.02e-7 QT interval; CESC cis rs4132509 0.515 rs76243949 chr1:243674094 G/A cg21452805 chr1:244014465 NA 0.48 5.33 0.31 2.08e-7 RR interval (heart rate); CESC cis rs3733585 0.753 rs12500805 chr4:10017979 C/T cg02734326 chr4:10020555 SLC2A9 0.49 6.91 0.39 3.54e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7089973 0.604 rs2420069 chr10:116605103 A/G cg23260525 chr10:116636907 FAM160B1 0.4 7.2 0.4 6.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg06550200 chr5:1325588 CLPTM1L 0.65 9.7 0.51 3.09e-19 Lung cancer; CESC cis rs7520050 0.807 rs4274104 chr1:46217941 T/C cg03146154 chr1:46216737 IPP 0.5 6.71 0.38 1.16e-10 Red blood cell count;Reticulocyte count; CESC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg08470875 chr2:26401718 FAM59B 0.75 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg25036284 chr2:26402008 FAM59B 0.88 9.99 0.52 3.79e-20 Gut microbiome composition (summer); CESC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.87 9.07 0.49 2.8e-17 Platelet count; CESC cis rs4242434 0.927 rs720746 chr8:22471399 T/C cg03733263 chr8:22462867 KIAA1967 0.92 13.81 0.65 4.86e-33 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs7618501 1.000 rs7372725 chr3:49790544 C/A cg24308560 chr3:49941425 MST1R 0.51 6.95 0.39 2.89e-11 Intelligence (multi-trait analysis); CESC cis rs73019876 0.869 rs2522096 chr19:22123417 C/A cg11619707 chr19:22235551 ZNF257 -0.31 -5.78 -0.33 2.14e-8 Testicular germ cell tumor; CESC cis rs11098499 0.863 rs7664986 chr4:120429952 A/C cg24375607 chr4:120327624 NA 0.44 5.28 0.31 2.67e-7 Corneal astigmatism; CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg04151612 chr3:9932217 JAGN1 -0.42 -6.17 -0.35 2.48e-9 Breast cancer; CESC cis rs17376456 0.597 rs6869110 chr5:93355531 G/A cg25358565 chr5:93447407 FAM172A -0.46 -5.45 -0.32 1.17e-7 Diabetic retinopathy; CESC cis rs2929278 0.617 rs524908 chr15:44187991 G/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.44 -6.05 -0.35 4.92e-9 Schizophrenia; CESC trans rs4424809 0.614 rs7336959 chr13:85571724 C/G cg05918002 chr17:5019452 ZNF232 -0.64 -6.08 -0.35 4.2e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.3.1042801R chr3:49084142 QRICH1 0.44 6.01 0.35 6.16e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13633754 chr9:95858523 C9orf89 -0.44 -6.19 -0.36 2.33e-9 Fibrinogen levels; CESC cis rs2204008 0.782 rs11514339 chr12:38236670 G/A cg13010199 chr12:38710504 ALG10B 0.52 6.43 0.37 5.91e-10 Bladder cancer; CESC cis rs425277 1.000 rs262647 chr1:2095699 C/T cg04315214 chr1:2043799 PRKCZ -0.37 -5.28 -0.31 2.74e-7 Height; CESC cis rs11122272 0.735 rs2437148 chr1:231513979 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs2191566 0.691 rs56320525 chr19:44587879 C/T cg20607764 chr19:44506953 ZNF230 -0.4 -5.17 -0.3 4.53e-7 Acute lymphoblastic leukemia (childhood); CESC cis rs6426558 0.537 rs1320494 chr1:227241300 A/T cg10327440 chr1:227177885 CDC42BPA 0.48 6.0 0.35 6.39e-9 Neutrophil percentage of white cells; CESC cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg20573242 chr4:122745356 CCNA2 0.65 8.05 0.44 2.81e-14 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16739247 chr1:76252438 SNORD45C;SNORD45A;RABGGTB 0.49 6.23 0.36 1.81e-9 Gut microbiota (bacterial taxa); CESC cis rs7818345 0.967 rs6990357 chr8:19276681 C/G cg11303988 chr8:19266685 CSGALNACT1 0.33 5.99 0.35 6.77e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg11168104 chr5:1857477 NA -0.36 -5.17 -0.3 4.55e-7 Cardiovascular disease risk factors; CESC cis rs9611565 0.592 rs9611613 chr22:41961831 T/C cg06481639 chr22:41940642 POLR3H -0.58 -6.42 -0.37 6.32e-10 Vitiligo; CESC cis rs11640533 0.901 rs11862250 chr16:53415038 C/A cg04653913 chr16:53407753 NA 0.47 6.2 0.36 2.21e-9 Intelligence (multi-trait analysis); CESC trans rs9929218 0.906 rs9932679 chr16:68751904 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -10.11 -0.53 1.52e-20 Colorectal cancer; CESC cis rs2304069 0.545 rs7728248 chr5:149394965 A/G cg12661370 chr5:149340060 SLC26A2 0.43 5.67 0.33 3.75e-8 HIV-1 control; CESC cis rs7520050 0.966 rs12139630 chr1:46350935 A/G cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.42e-7 Red blood cell count;Reticulocyte count; CESC cis rs78456975 1.000 rs11883965 chr2:1560062 T/C cg01028140 chr2:1542097 TPO -0.5 -5.37 -0.31 1.69e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4889855 0.556 rs11547301 chr17:78518780 C/T cg16591659 chr17:78472290 NA 0.38 6.03 0.35 5.35e-9 Fractional excretion of uric acid; CESC trans rs78049276 0.736 rs17612742 chr4:148414651 C/T cg13149281 chr14:23389818 RBM23;PRMT5 0.62 6.32 0.36 1.13e-9 Pulse pressure; CESC trans rs28549925 0.590 rs9690470 chr7:16987440 G/C cg12639933 chr12:57626296 SHMT2 0.91 6.18 0.35 2.42e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs921968 0.565 rs12612395 chr2:219621642 G/C cg02176678 chr2:219576539 TTLL4 -0.43 -7.56 -0.42 6.81e-13 Mean corpuscular hemoglobin concentration; CESC cis rs34638657 0.789 rs2303264 chr16:82203711 G/T cg09439754 chr16:82129088 HSD17B2 -0.35 -5.83 -0.34 1.64e-8 Lung adenocarcinoma; CESC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg17372223 chr3:52568218 NT5DC2 0.43 6.54 0.37 3.21e-10 Bipolar disorder; CESC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.44 -5.76 -0.33 2.36e-8 Tonsillectomy; CESC cis rs757110 0.526 rs757081 chr11:17351683 C/G cg15432903 chr11:17409602 KCNJ11 -0.48 -6.62 -0.38 1.97e-10 Type 2 diabetes; CESC cis rs35079168 0.923 rs10858277 chr9:137287959 G/A cg13941235 chr9:137270186 RXRA -0.31 -5.66 -0.33 3.86e-8 Intelligence; CESC cis rs929354 0.651 rs6951298 chr7:156949149 T/C cg05182265 chr7:156933206 UBE3C -0.5 -7.29 -0.41 3.49e-12 Body mass index; CESC cis rs55788414 0.932 rs12716908 chr16:81186245 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.58 -0.37 2.44e-10 Left ventricular obstructive tract defect (maternal effect); CESC cis rs9527 0.590 rs11191540 chr10:104822809 G/C cg04362960 chr10:104952993 NT5C2 0.45 5.76 0.33 2.34e-8 Arsenic metabolism; CESC cis rs7223966 1.000 rs9901112 chr17:61730617 C/G cg11494091 chr17:61959527 GH2 0.38 5.1 0.3 6.42e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.57 0.61 9.49e-29 Alzheimer's disease; CESC cis rs1048238 0.506 rs698890 chr1:16267371 C/G cg21385522 chr1:16154831 NA -0.45 -5.7 -0.33 3.22e-8 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05160409 chr11:60681264 TMEM109 -0.54 -6.54 -0.37 3.21e-10 Gut microbiome composition (summer); CESC trans rs758324 0.606 rs247276 chr5:131469004 C/T cg26954464 chr16:67472862 ATP6V0D1 0.45 6.14 0.35 2.92e-9 Alzheimer's disease in APOE e4- carriers; CESC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg09455208 chr3:40491958 NA 0.49 8.14 0.45 1.52e-14 Renal cell carcinoma; CESC cis rs3540 0.533 rs1869179 chr15:90895564 A/C cg22089800 chr15:90895588 ZNF774 0.77 10.97 0.56 2.43e-23 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs9486715 0.838 rs7452350 chr6:96883326 C/A cg06623918 chr6:96969491 KIAA0776 0.91 14.05 0.65 6.83e-34 Headache; CESC cis rs6963495 0.651 rs3892298 chr7:105152187 A/G cg13798780 chr7:105162888 PUS7 0.76 7.77 0.43 1.79e-13 Bipolar disorder (body mass index interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16583193 chr19:3652060 PIP5K1C 0.49 6.27 0.36 1.5e-9 Fibrinogen levels; CESC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg15145296 chr3:125709740 NA -0.48 -5.24 -0.31 3.22e-7 Blood pressure (smoking interaction); CESC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.03e-11 Tonsillectomy; CESC cis rs61996546 0.622 rs61998698 chr15:26868306 G/C cg15066197 chr15:26874202 GABRB3 -0.34 -5.06 -0.3 8.04e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs7208859 0.673 rs216420 chr17:28938508 C/T cg17105886 chr17:28927953 LRRC37B2 0.59 5.14 0.3 5.26e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01213128 chr5:138629571 MATR3 0.54 6.34 0.36 9.84e-10 Gut microbiome composition (summer); CESC cis rs4423214 1.000 rs12808368 chr11:71170817 C/T cg05163923 chr11:71159392 DHCR7 0.78 10.34 0.54 2.91e-21 Vitamin D levels; CESC cis rs17818399 0.890 rs34752561 chr2:46850150 G/A cg02822958 chr2:46747628 ATP6V1E2 0.46 5.51 0.32 8.47e-8 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10460643 chr3:53205536 PRKCD -0.56 -6.84 -0.39 5.43e-11 Gut microbiome composition (summer); CESC trans rs3741489 1.000 rs3741489 chr12:133417802 A/G cg24132527 chr5:140019269 TMCO6 1.11 7.52 0.42 8.38e-13 Cognitive function; CESC cis rs34779708 0.733 rs7086715 chr10:35541840 A/G cg03585969 chr10:35415529 CREM 0.56 6.42 0.37 6.15e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs6831352 0.734 rs1311620 chr4:100013091 C/T cg13256891 chr4:100009986 ADH5 0.69 8.16 0.45 1.32e-14 Alcohol dependence; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg01622965 chr7:98476371 TRRAP 0.49 6.38 0.36 8.08e-10 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.512 rs165251 chr4:98758490 C/G cg05340658 chr4:99064831 C4orf37 0.51 6.65 0.38 1.63e-10 Colonoscopy-negative controls vs population controls; CESC cis rs9787249 0.957 rs10888958 chr1:40211737 T/C cg19912559 chr1:40204330 PPIE 0.43 6.57 0.37 2.63e-10 Blood protein levels; CESC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg21433558 chr17:40837037 CNTNAP1 0.72 11.77 0.59 5.35e-26 Colorectal or endometrial cancer; CESC cis rs8180040 0.620 rs9845728 chr3:47103376 C/T cg27129171 chr3:47204927 SETD2 0.66 9.71 0.51 2.81e-19 Colorectal cancer; CESC cis rs4971059 0.654 rs7364524 chr1:155121922 A/G cg22049894 chr1:155113146 DPM3 0.47 6.07 0.35 4.32e-9 Breast cancer; CESC cis rs10872587 0.657 rs11155459 chr6:146578751 A/G cg23711669 chr6:146136114 FBXO30 -0.63 -7.46 -0.42 1.24e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.909 rs73842633 chr4:120375464 G/A cg24375607 chr4:120327624 NA 0.46 5.39 0.31 1.57e-7 Corneal astigmatism; CESC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg18479299 chr3:125709523 NA -0.48 -5.06 -0.3 7.98e-7 Blood pressure (smoking interaction); CESC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg07701084 chr6:150067640 NUP43 0.45 6.47 0.37 4.76e-10 Lung cancer; CESC cis rs28374715 0.578 rs7165914 chr15:41632451 C/T cg18705301 chr15:41695430 NDUFAF1 -1.06 -15.45 -0.69 7.91e-39 Ulcerative colitis; CESC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs4888262 0.545 rs7195499 chr16:74693973 C/G cg01733217 chr16:74700730 RFWD3 0.91 12.21 0.6 1.62e-27 Testicular germ cell tumor; CESC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 7.5 0.42 9.57e-13 Total body bone mineral density; CESC cis rs765787 0.505 rs4439707 chr15:45524216 G/A cg24006582 chr15:45444508 DUOX1 0.57 6.82 0.39 6.17e-11 Uric acid levels; CESC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg23172400 chr8:95962367 TP53INP1 -0.43 -8.98 -0.48 5.05e-17 Type 2 diabetes; CESC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg24549020 chr5:56110836 MAP3K1 0.62 6.49 0.37 4.21e-10 Initial pursuit acceleration; CESC cis rs7605827 0.930 rs2890487 chr2:15594938 A/G cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26399201 chr5:132149404 ANKRD43 0.59 6.15 0.35 2.9e-9 Gut microbiome composition (summer); CESC cis rs2108225 0.837 rs6959729 chr7:107446180 A/C cg18560240 chr7:107437656 SLC26A3 -0.4 -5.38 -0.31 1.64e-7 Ulcerative colitis; CESC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.05 0.4 1.57e-11 Height; CESC cis rs1975974 0.935 rs67979358 chr17:21723834 G/C cg18423549 chr17:21743878 NA -0.51 -7.12 -0.4 1.04e-11 Psoriasis; CESC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg11941060 chr3:133502564 NA -0.46 -6.12 -0.35 3.36e-9 Iron status biomarkers; CESC cis rs763014 0.865 rs2018789 chr16:632051 T/C cg00802000 chr16:706648 WDR90 -0.41 -6.12 -0.35 3.33e-9 Height; CESC cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg07636037 chr3:49044803 WDR6 1.01 18.31 0.75 5.7e-49 Parkinson's disease; CESC cis rs7917772 0.582 rs12782153 chr10:104368294 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.4 -5.39 -0.31 1.59e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs10760279 0.584 rs10760280 chr9:126112812 A/G cg14503395 chr9:126128745 CRB2 0.48 5.86 0.34 1.35e-8 Body mass index; CESC cis rs9300255 0.602 rs1727306 chr12:123665695 A/G cg05973401 chr12:123451056 ABCB9 0.49 5.49 0.32 9.51e-8 Neutrophil percentage of white cells; CESC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg22508957 chr16:3507546 NAT15 -0.56 -9.04 -0.49 3.28e-17 Tuberculosis; CESC cis rs9462846 0.691 rs7744454 chr6:42914041 C/G cg05552183 chr6:42928497 GNMT 0.52 6.02 0.35 5.77e-9 Blood protein levels; CESC cis rs7809950 0.678 rs2237659 chr7:106847492 G/T cg23024343 chr7:107201750 COG5 0.49 5.88 0.34 1.2e-8 Coronary artery disease; CESC cis rs360071 0.841 rs1223246 chr1:226093362 T/C cg17950169 chr1:226067900 TMEM63A 0.32 5.07 0.3 7.32e-7 Response to radiotherapy in prostate cancer (toxicity, rectal bleeding); CESC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs4889855 0.511 rs9908700 chr17:78466594 A/G cg16591659 chr17:78472290 NA -0.53 -7.71 -0.43 2.56e-13 Fractional excretion of uric acid; CESC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.43 -5.8 -0.34 1.93e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9584850 0.794 rs9630321 chr13:99106979 C/G cg20750642 chr13:99100586 FARP1 -0.39 -5.86 -0.34 1.39e-8 Neuroticism; CESC cis rs709400 0.567 rs28496120 chr14:103897899 C/T cg12935359 chr14:103987150 CKB -0.49 -7.09 -0.4 1.24e-11 Body mass index; CESC cis rs12477438 0.677 rs12475034 chr2:99699464 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -8.0 -0.44 3.96e-14 Chronic sinus infection; CESC cis rs7149337 0.805 rs71422017 chr14:51612417 A/T cg23942311 chr14:51606299 NA 0.48 8.24 0.45 8.16e-15 Cancer; CESC cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg00825309 chr19:58991885 ZNF446 -0.58 -8.31 -0.45 5.12e-15 Uric acid clearance; CESC cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg06484146 chr7:12443880 VWDE -0.7 -8.69 -0.47 3.72e-16 Coronary artery disease; CESC cis rs644799 1.000 rs680134 chr11:95559517 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.73 0.38 1.06e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.5 0.37 3.92e-10 Bipolar disorder; CESC cis rs5743618 0.537 rs7694115 chr4:38779094 A/G cg02016764 chr4:38805732 TLR1 -0.32 -5.13 -0.3 5.66e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs75804782 0.521 rs58568091 chr2:239430582 G/A cg18131467 chr2:239335373 ASB1 -0.7 -5.44 -0.32 1.18e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs4077515 0.967 rs4078099 chr9:139267533 G/A cg14169450 chr9:139327907 INPP5E 0.36 5.21 0.3 3.84e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs6032067 0.929 rs2143944 chr20:43819370 G/A cg11264863 chr20:43835661 SEMG1 0.49 5.29 0.31 2.5e-7 Blood protein levels; CESC trans rs7615952 0.932 rs13321217 chr3:125631771 G/A cg07211511 chr3:129823064 LOC729375 -1.09 -15.57 -0.69 2.97e-39 Blood pressure (smoking interaction); CESC cis rs13385 0.723 rs28722951 chr5:139609952 T/G cg26211634 chr5:139558579 C5orf32 0.47 5.19 0.3 4.23e-7 Atrial fibrillation; CESC cis rs3806843 0.676 rs778594 chr5:140027304 T/C cg16179182 chr5:140090404 VTRNA1-1 0.44 5.57 0.32 6.19e-8 Depressive symptoms (multi-trait analysis); CESC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg09509183 chr1:209979624 IRF6 0.44 5.07 0.3 7.39e-7 Cleft lip with or without cleft palate; CESC cis rs3740909 1.000 rs3740911 chr11:125889755 C/T cg10589353 chr11:126294637 KIRREL3 0.49 5.66 0.33 3.99e-8 Blood protein levels; CESC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg20151795 chr6:28129481 ZNF389 0.45 5.72 0.33 2.9e-8 Depression; CESC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs12477438 0.700 rs12467679 chr2:99654449 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC trans rs10506458 0.834 rs12426893 chr12:63388120 G/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.31 -17.59 -0.73 2.03e-46 Hemostatic factors and hematological phenotypes; CESC cis rs6430585 0.528 rs114760827 chr2:136661110 G/A cg07169764 chr2:136633963 MCM6 1.23 16.5 0.71 1.49e-42 Corneal structure; CESC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg23758822 chr17:41437982 NA 1.01 15.2 0.68 5.81e-38 Menopause (age at onset); CESC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2479106 0.509 rs4836938 chr9:126367435 G/T cg16191174 chr9:126692580 DENND1A 0.38 5.19 0.3 4.28e-7 Polycystic ovary syndrome; CESC trans rs1814175 0.867 rs7926002 chr11:49616018 A/G cg15704280 chr7:45808275 SEPT13 -0.98 -16.77 -0.72 1.6700000000000001e-43 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23838375 chr17:72732946 RAB37 0.52 6.06 0.35 4.67e-9 Gut microbiome composition (summer); CESC cis rs4835473 0.736 rs6851661 chr4:144771740 T/G cg25736465 chr4:144833511 NA 0.45 6.65 0.38 1.67e-10 Immature fraction of reticulocytes; CESC trans rs561341 0.824 rs1978115 chr17:30220776 A/C cg27661571 chr11:113659931 NA -0.62 -6.35 -0.36 9.13e-10 Hip circumference adjusted for BMI; CESC cis rs9300255 0.602 rs1626899 chr12:123708063 A/G cg19016782 chr12:123741754 C12orf65 -0.45 -6.55 -0.37 2.97e-10 Neutrophil percentage of white cells; CESC cis rs72781680 1.000 rs12616985 chr2:24165511 A/C cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs3820068 0.581 rs6669417 chr1:15922371 G/T cg16988262 chr1:15930761 NA 0.33 5.29 0.31 2.52e-7 Systolic blood pressure; CESC cis rs4604732 0.678 rs74154674 chr1:247625685 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg08736216 chr1:53307985 ZYG11A 0.3 5.05 0.3 8.16e-7 Monocyte count; CESC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.32 -0.31 2.23e-7 Developmental language disorder (linguistic errors); CESC cis rs7312933 1.000 rs11181328 chr12:42504679 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.44 5.72 0.33 2.94e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg04287289 chr16:89883240 FANCA 0.89 15.41 0.69 1.1e-38 Vitiligo; CESC cis rs61931739 0.517 rs7958856 chr12:34294737 T/C cg19457237 chr12:34500585 NA -0.38 -5.19 -0.3 4.19e-7 Morning vs. evening chronotype; CESC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg11644478 chr21:40555479 PSMG1 0.99 15.22 0.68 5.25e-38 Cognitive function; CESC trans rs60843830 1.000 rs11553746 chr2:272203 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 8.45 0.46 1.94e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg23131131 chr22:24373011 LOC391322 -0.7 -9.86 -0.52 9.82e-20 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs2243480 1.000 rs34136756 chr7:65381256 A/G cg12463550 chr7:65579703 CRCP 0.7 5.58 0.32 5.87e-8 Diabetic kidney disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15027563 chr16:11038165 CLEC16A 0.52 6.95 0.39 2.85e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs911555 0.673 rs7144271 chr14:103890674 A/G cg12935359 chr14:103987150 CKB -0.54 -7.83 -0.43 1.2e-13 Intelligence (multi-trait analysis); CESC cis rs12545109 0.800 rs1837620 chr8:57399473 C/A cg09654669 chr8:57350985 NA -0.57 -7.22 -0.41 5.35e-12 Obesity-related traits; CESC cis rs4889855 0.530 rs4890052 chr17:78564245 G/T cg16591659 chr17:78472290 NA 0.34 5.62 0.33 4.9e-8 Fractional excretion of uric acid; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20510080 chr22:51021491 LOC100144603;CHKB-CPT1B;CHKB -0.5 -6.2 -0.36 2.21e-9 Asthma; CESC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg25036284 chr2:26402008 FAM59B -0.84 -9.51 -0.5 1.19e-18 Gut microbiome composition (summer); CESC cis rs4280164 0.945 rs2281472 chr14:24775846 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 0.51 5.77 0.33 2.26e-8 Parent of origin effect on language impairment (paternal); CESC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg22535103 chr8:58192502 C8orf71 -0.96 -12.41 -0.61 3.38e-28 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01198338 chr7:75508496 RHBDD2 0.53 6.15 0.35 2.78e-9 Gut microbiome composition (summer); CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg04234412 chr22:24373322 LOC391322 -0.66 -9.7 -0.51 3.04e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9894429 0.789 rs7213849 chr17:79567610 C/T cg18240062 chr17:79603768 NPLOC4 -0.89 -13.32 -0.63 2.53e-31 Eye color traits; CESC cis rs11677416 1.000 rs17561 chr2:113537223 C/A cg27083787 chr2:113543245 IL1A 0.6 7.49 0.42 1.01e-12 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs4409675 0.597 rs1000431 chr1:28225114 C/T cg23691781 chr1:28212827 C1orf38 0.28 5.63 0.33 4.7e-8 Corneal astigmatism; CESC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg10691866 chr7:65817282 TPST1 0.31 5.06 0.3 7.76e-7 Aortic root size; CESC cis rs17666538 0.535 rs168062 chr8:632444 T/A cg13264159 chr8:625131 ERICH1 -0.71 -5.68 -0.33 3.47e-8 IgG glycosylation; CESC cis rs2929278 0.562 rs8033846 chr15:44035363 A/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.47 -7.48 -0.42 1.09e-12 Schizophrenia; CESC cis rs7551222 0.716 rs4951078 chr1:204491802 A/G cg20240347 chr1:204465584 NA -0.28 -5.57 -0.32 6.31e-8 Schizophrenia; CESC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg05368731 chr17:41323189 NBR1 0.79 10.96 0.56 2.64e-23 Menopause (age at onset); CESC cis rs62158211 0.955 rs1823125 chr2:114090412 C/T cg17784749 chr2:114082611 LOC440839 -0.76 -9.17 -0.49 1.32e-17 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CESC cis rs7586673 0.930 rs6432667 chr2:161905001 T/C cg16506815 chr2:162101123 NA 0.47 6.17 0.35 2.54e-9 Intelligence (multi-trait analysis); CESC cis rs2797160 1.000 rs1777225 chr6:126018270 T/C cg05901451 chr6:126070800 HEY2 0.46 6.48 0.37 4.56e-10 Endometrial cancer; CESC cis rs9488822 0.702 rs10872141 chr6:116323246 C/A cg18764771 chr6:116381957 FRK 0.22 5.44 0.32 1.21e-7 Cholesterol, total;LDL cholesterol; CESC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg18099408 chr3:52552593 STAB1 -0.3 -5.11 -0.3 6.18e-7 Bipolar disorder; CESC cis rs4253772 0.872 rs45576140 chr22:46638216 C/G cg00784671 chr22:46762841 CELSR1 -0.51 -5.27 -0.31 2.87e-7 LDL cholesterol;Cholesterol, total; CESC cis rs881375 0.715 rs10985073 chr9:123643855 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.71 0.43 2.59e-13 Rheumatoid arthritis; CESC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.41 -0.37 6.76e-10 Life satisfaction; CESC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg23161317 chr6:28129485 ZNF389 0.49 6.19 0.36 2.28e-9 Parkinson's disease; CESC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg07677032 chr17:61819896 STRADA 0.44 5.9 0.34 1.1e-8 Prudent dietary pattern; CESC cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg02574844 chr11:5959923 NA -0.44 -5.53 -0.32 7.81e-8 DNA methylation (variation); CESC cis rs6840360 0.593 rs3805356 chr4:152680701 C/T cg22705602 chr4:152727874 NA 0.35 5.03 0.3 9.23e-7 Intelligence (multi-trait analysis); CESC cis rs74181299 0.819 rs2723087 chr2:65298282 T/A cg05010058 chr2:65284262 CEP68 0.34 5.7 0.33 3.14e-8 Pulse pressure; CESC cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg03433033 chr1:76189801 ACADM 0.64 7.52 0.42 8.69e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg20503657 chr10:835505 NA 0.82 8.12 0.45 1.71e-14 Eosinophil percentage of granulocytes; CESC cis rs2072499 0.750 rs72708291 chr1:156177285 A/T cg25208724 chr1:156163844 SLC25A44 0.92 11.76 0.59 5.87e-26 Testicular germ cell tumor; CESC cis rs10129255 0.518 rs7143784 chr14:107143294 A/G cg07958169 chr14:107095056 NA -0.53 -8.7 -0.47 3.54e-16 Kawasaki disease; CESC cis rs7589342 0.899 rs11885225 chr2:106486548 T/C cg16077055 chr2:106428750 NCK2 0.5 7.22 0.41 5.51e-12 Addiction; CESC cis rs9611565 0.512 rs7291736 chr22:42124874 C/A cg06481639 chr22:41940642 POLR3H 0.59 5.91 0.34 1.07e-8 Vitiligo; CESC cis rs9811920 0.809 rs4928235 chr3:99706870 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -7.66 -0.43 3.42e-13 Axial length; CESC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg11644478 chr21:40555479 PSMG1 1.02 16.31 0.71 7.16e-42 Cognitive function; CESC cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.76 -10.98 -0.56 2.34e-23 Platelet count; CESC cis rs34172651 0.537 rs8049014 chr16:24698903 A/G cg06028605 chr16:24865363 SLC5A11 0.45 6.74 0.38 9.92e-11 Intelligence (multi-trait analysis); CESC cis rs2625529 0.775 rs62023342 chr15:72161305 A/C cg16672083 chr15:72433130 SENP8 -0.4 -5.17 -0.3 4.53e-7 Red blood cell count; CESC cis rs2243480 1.000 rs1723267 chr7:65473314 G/A cg12463550 chr7:65579703 CRCP 0.72 5.81 0.34 1.8e-8 Diabetic kidney disease; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09196146 chr14:90042364 PRO1768;FOXN3 -0.54 -7.49 -0.42 1.03e-12 Prostate cancer (SNP x SNP interaction); CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.39 5.69 0.33 3.29e-8 Electroencephalogram traits; CESC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg16325326 chr1:53192061 ZYG11B -0.98 -17.59 -0.73 1.95e-46 Monocyte count; CESC cis rs868036 0.681 rs28688285 chr15:68110297 T/C cg08079166 chr15:68083412 MAP2K5 0.41 5.6 0.33 5.49e-8 Restless legs syndrome; CESC cis rs16910800 0.689 rs7128636 chr11:23164689 C/T cg20040320 chr11:23191996 NA -0.64 -6.08 -0.35 4.07e-9 Cancer; CESC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.57 -7.87 -0.44 9.06e-14 Electroencephalogram traits; CESC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg22105103 chr4:187893119 NA 0.46 6.48 0.37 4.54e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.863 rs1010739 chr4:120463471 C/T cg09307838 chr4:120376055 NA 0.92 12.91 0.62 6.68e-30 Corneal astigmatism; CESC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg05872129 chr22:39784769 NA -0.84 -11.68 -0.58 1.03e-25 Intelligence (multi-trait analysis); CESC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg12463550 chr7:65579703 CRCP 0.56 7.09 0.4 1.2e-11 Aortic root size; CESC cis rs11677416 1.000 rs3783555 chr2:113531093 T/C cg27083787 chr2:113543245 IL1A 0.41 5.17 0.3 4.53e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs644799 0.672 rs61902245 chr11:95517737 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.78 11.75 0.59 6.11e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6496667 0.557 rs2601203 chr15:90958129 T/G cg22089800 chr15:90895588 ZNF774 0.45 5.77 0.33 2.25e-8 Rheumatoid arthritis; CESC cis rs4955124 0.730 rs58048871 chr3:32060067 G/A cg05935571 chr3:32023257 ZNF860;OSBPL10 0.84 5.81 0.34 1.78e-8 Schizophrenia; CESC cis rs3806843 0.900 rs2563254 chr5:140142701 T/C cg26395211 chr5:140044315 WDR55 0.39 5.17 0.3 4.51e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7100689 0.784 rs11202699 chr10:82131453 A/G cg00277334 chr10:82204260 NA -0.59 -7.45 -0.42 1.36e-12 Post bronchodilator FEV1; CESC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg27170947 chr2:26402098 FAM59B 0.79 9.1 0.49 2.2e-17 Gut microbiome composition (summer); CESC cis rs4604732 0.631 rs74154673 chr1:247625629 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.51 6.36 0.36 8.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs6942756 0.531 rs4731569 chr7:128930828 C/T cg02491457 chr7:128862824 NA 0.45 6.39 0.37 7.43e-10 White matter hyperintensity burden; CESC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.08 0.76 1.12e-51 Height; CESC cis rs11252926 0.599 rs11252213 chr10:454694 C/T cg03684893 chr10:554711 DIP2C -0.37 -5.36 -0.31 1.79e-7 Psychosis in Alzheimer's disease; CESC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg05861140 chr6:150128134 PCMT1 -0.35 -5.07 -0.3 7.45e-7 Lung cancer; CESC cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg03676636 chr4:99064102 C4orf37 0.33 5.11 0.3 6.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs4969178 0.930 rs12452576 chr17:76386037 A/C cg05887092 chr17:76393375 PGS1 0.57 9.02 0.48 3.85e-17 HDL cholesterol levels; CESC cis rs9291683 0.527 rs3822247 chr4:10094671 G/A cg00071950 chr4:10020882 SLC2A9 -0.66 -10.55 -0.54 6.11e-22 Bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26985912 chr7:76179317 LOC100133091 -0.53 -6.23 -0.36 1.86e-9 Gut microbiome composition (summer); CESC cis rs6598955 0.670 rs7531518 chr1:26539749 T/C cg04990556 chr1:26633338 UBXN11 -0.75 -10.63 -0.55 3.15e-22 Obesity-related traits; CESC cis rs4727027 0.870 rs11525060 chr7:148801091 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.25 0.31 3.08e-7 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs11792861 0.781 rs28361152 chr9:111727529 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 6.64 0.38 1.79e-10 Menarche (age at onset); CESC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg10691866 chr7:65817282 TPST1 0.33 5.5 0.32 8.76e-8 Aortic root size; CESC cis rs6120849 0.754 rs6088667 chr20:33566722 A/C cg24642439 chr20:33292090 TP53INP2 0.63 6.55 0.37 2.89e-10 Protein C levels; CESC trans rs11098499 0.908 rs28559989 chr4:120386627 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.93 0.52 5.63e-20 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00219956 chr16:30794205 ZNF629 -0.64 -7.63 -0.42 4.27e-13 Gut microbiome composition (summer); CESC trans rs453301 0.624 rs330056 chr8:9089695 A/T cg06636001 chr8:8085503 FLJ10661 -0.52 -6.7 -0.38 1.24e-10 Joint mobility (Beighton score); CESC cis rs34779708 0.966 rs4934736 chr10:35496868 G/A cg03585969 chr10:35415529 CREM 0.75 9.92 0.52 6.22e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs9951602 1.000 rs9949784 chr18:76649994 A/G cg02800362 chr5:177631904 HNRNPAB 0.63 6.87 0.39 4.65e-11 Obesity-related traits; CESC cis rs863345 0.933 rs1418843 chr1:158450382 A/G cg12129480 chr1:158549410 OR10X1 0.31 6.3 0.36 1.25e-9 Pneumococcal bacteremia; CESC cis rs1580019 0.587 rs6972365 chr7:32548931 T/A cg06627557 chr7:32535165 LSM5;AVL9 1.06 18.8 0.76 1.12e-50 Cognitive ability; CESC cis rs7208859 0.524 rs73988172 chr17:29086332 A/C cg13385521 chr17:29058706 SUZ12P 0.81 6.44 0.37 5.52e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs75229567 0.618 rs11177853 chr12:70184924 A/G cg10114359 chr12:70132523 RAB3IP 1.34 8.39 0.46 3.03e-15 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; CESC cis rs13096760 1 rs13096760 chr3:49476806 T/C cg02487422 chr3:49467188 NICN1 0.56 8.15 0.45 1.49e-14 Intelligence (multi-trait analysis); CESC cis rs17125944 0.505 rs75194546 chr14:53212069 A/C cg13660082 chr14:53194042 PSMC6 -0.68 -5.94 -0.34 8.96e-9 Alzheimer's disease (late onset); CESC cis rs55882075 0.967 rs59666900 chr5:179147641 C/T cg14593053 chr5:179126677 CANX 0.45 5.99 0.35 6.99e-9 Monocyte percentage of white cells; CESC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg06028605 chr16:24865363 SLC5A11 0.55 8.13 0.45 1.62e-14 Intelligence (multi-trait analysis); CESC cis rs7605827 0.930 rs1035247 chr2:15617846 T/A cg19274914 chr2:15703543 NA 0.36 6.42 0.37 6.38e-10 Educational attainment (years of education); CESC trans rs5756813 0.727 rs4239889 chr22:38140352 T/G cg19894588 chr14:64061835 NA -0.66 -7.81 -0.43 1.35e-13 Optic cup area;Vertical cup-disc ratio; CESC cis rs10392 0.543 rs4300896 chr20:37580130 A/C cg27552599 chr20:37590471 DHX35 0.39 5.69 0.33 3.39e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs3126085 0.935 rs11204947 chr1:152218257 G/T cg26876637 chr1:152193138 HRNR -0.45 -5.11 -0.3 6.14e-7 Atopic dermatitis; CESC cis rs4664304 1.000 rs3806603 chr2:160761808 T/C cg03641300 chr2:160917029 PLA2R1 -0.48 -6.78 -0.38 8.02e-11 Crohn's disease;Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09447007 chr7:43769356 C7orf44 -0.58 -6.55 -0.37 2.9e-10 Gut microbiome composition (summer); CESC trans rs2727020 0.615 rs10128582 chr11:49447424 C/T cg03929089 chr4:120376271 NA -0.81 -12.59 -0.61 8.43e-29 Coronary artery disease; CESC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.6 0.38 2.17e-10 Prudent dietary pattern; CESC cis rs4835473 0.897 rs7687317 chr4:144630163 T/A cg25736465 chr4:144833511 NA 0.4 6.17 0.35 2.59e-9 Immature fraction of reticulocytes; CESC cis rs7520050 0.966 rs7522601 chr1:46419021 G/A cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.54e-8 Red blood cell count;Reticulocyte count; CESC cis rs72634258 0.554 rs4908704 chr1:7918904 A/G cg00042356 chr1:8021962 PARK7 0.58 5.55 0.32 6.83e-8 Inflammatory bowel disease; CESC cis rs8141529 0.584 rs58004020 chr22:29257050 A/T cg02153584 chr22:29168773 CCDC117 0.61 8.55 0.46 1.03e-15 Lymphocyte counts; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg06812225 chr1:204485782 MDM4 0.46 6.49 0.37 4.15e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7208859 0.673 rs9912122 chr17:29140716 C/A cg19761014 chr17:28927070 LRRC37B2 0.68 6.72 0.38 1.11e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6460942 1.000 rs7796485 chr7:12405676 G/A cg06484146 chr7:12443880 VWDE -0.79 -8.75 -0.47 2.47e-16 Coronary artery disease; CESC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg22143856 chr6:28129313 ZNF389 0.49 6.21 0.36 2.02e-9 Depression; CESC cis rs611744 0.647 rs589347 chr8:109253929 T/A cg21045802 chr8:109455806 TTC35 0.49 6.06 0.35 4.71e-9 Dupuytren's disease; CESC cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg11764359 chr7:65958608 NA 0.84 9.72 0.51 2.63e-19 Aortic root size; CESC cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg18512352 chr11:47633146 NA -0.52 -7.57 -0.42 6.2e-13 Subjective well-being; CESC cis rs2228479 0.850 rs2238532 chr16:89863672 T/C cg04013166 chr16:89971882 TCF25 0.76 6.49 0.37 4.31e-10 Skin colour saturation; CESC cis rs9913156 0.707 rs72835625 chr17:4560274 G/A cg00122941 chr17:4613640 ARRB2 0.85 9.99 0.52 3.79e-20 Lymphocyte counts; CESC cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.84 13.61 0.64 2.42e-32 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6460942 0.915 rs6460907 chr7:12304449 G/A cg02935154 chr7:12443704 VWDE -0.4 -5.54 -0.32 7.17e-8 Coronary artery disease; CESC cis rs2276314 1.000 rs16967317 chr18:33573400 A/G cg19628046 chr18:33552617 C18orf21 0.53 5.87 0.34 1.31e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7208859 0.623 rs9916725 chr17:29107471 A/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2963155 0.518 rs853184 chr5:142640901 C/T cg17617527 chr5:142782415 NR3C1 0.85 7.47 0.42 1.2e-12 Breast cancer; CESC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.1 0.53 1.62e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6696846 0.936 rs6662930 chr1:205041465 T/C cg00857998 chr1:205179979 DSTYK 0.55 7.15 0.4 8.5e-12 Red blood cell count; CESC cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 6.41 0.37 6.72e-10 Mean platelet volume; CESC trans rs10488821 0.648 rs544625 chr11:30516496 A/G cg04407762 chr4:113442791 NA -0.39 -6.33 -0.36 1.04e-9 QRS complex (12-leadsum); CESC cis rs9291683 0.588 rs35099040 chr4:10018839 T/C cg00071950 chr4:10020882 SLC2A9 0.9 16.87 0.72 7.08e-44 Bone mineral density; CESC cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg01181863 chr3:195395398 SDHAP2 -0.46 -5.34 -0.31 2.01e-7 Pancreatic cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19062112 chr14:103059054 RCOR1 0.59 6.18 0.35 2.41e-9 Gut microbiome composition (summer); CESC cis rs62103177 0.608 rs34383580 chr18:77833263 A/G cg12964065 chr18:77638022 KCNG2 -0.45 -5.28 -0.31 2.72e-7 Opioid sensitivity; CESC cis rs7618501 0.699 rs2681781 chr3:49898273 A/G cg24110177 chr3:50126178 RBM5 -0.45 -6.04 -0.35 5.06e-9 Intelligence (multi-trait analysis); CESC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg19468946 chr17:37922297 IKZF3 0.41 5.25 0.31 3.18e-7 Glomerular filtration rate (creatinine); CESC cis rs9443189 0.570 rs276684 chr6:76427065 A/G cg01950844 chr6:76311363 SENP6 -0.85 -8.25 -0.45 7.63e-15 Prostate cancer; CESC cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.51 0.32 8.39e-8 Personality dimensions; CESC cis rs17253792 0.822 rs77408754 chr14:56082047 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.73 0.33 2.77e-8 Putamen volume; CESC cis rs1832871 0.683 rs11752399 chr6:158711188 G/A cg07165851 chr6:158734300 TULP4 0.6 6.59 0.38 2.33e-10 Height; CESC cis rs2274273 0.870 rs6573009 chr14:55682324 A/C cg04306507 chr14:55594613 LGALS3 0.29 5.85 0.34 1.47e-8 Protein biomarker; CESC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg01516881 chr6:292596 DUSP22 -0.84 -11.53 -0.58 3.34e-25 Menopause (age at onset); CESC cis rs11031096 0.678 rs12222136 chr11:4180148 T/C cg18678763 chr11:4115507 RRM1 -0.43 -5.95 -0.34 8.24e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs6088580 0.634 rs4911418 chr20:32994257 G/A cg24642439 chr20:33292090 TP53INP2 -0.53 -6.99 -0.39 2.17e-11 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19201477 chr8:21776851 XPO7 -0.57 -6.21 -0.36 2.02e-9 Gut microbiome composition (summer); CESC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg26408565 chr15:76604113 ETFA -0.4 -5.81 -0.34 1.76e-8 Blood metabolite levels; CESC cis rs765787 0.530 rs12904331 chr15:45518293 C/T cg24006582 chr15:45444508 DUOX1 0.52 6.19 0.36 2.33e-9 Uric acid levels; CESC cis rs5997397 0.934 rs6005863 chr22:29156448 A/G cg02153584 chr22:29168773 CCDC117 0.55 7.4 0.41 1.76e-12 Red cell distribution width; CESC cis rs77956314 0.515 rs4767490 chr12:117435016 A/G cg25972092 chr12:117363249 FBXW8 0.55 6.04 0.35 5.22e-9 Subcortical brain region volumes;Hippocampal volume; CESC cis rs2415984 0.579 rs10140977 chr14:46955156 T/A cg14871534 chr14:47121158 RPL10L -0.35 -5.33 -0.31 2.05e-7 Number of children ever born; CESC trans rs7618501 0.602 rs2240327 chr3:50113034 C/T cg21659725 chr3:3221576 CRBN 0.55 7.93 0.44 5.99e-14 Intelligence (multi-trait analysis); CESC cis rs7236492 0.532 rs3786184 chr18:77195885 A/C cg15644404 chr18:77186268 NFATC1 -0.49 -5.57 -0.32 6.16e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs870825 0.616 rs2696037 chr4:185610940 C/T cg04058563 chr4:185651563 MLF1IP -0.58 -6.29 -0.36 1.3e-9 Blood protein levels; CESC cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg21395723 chr22:39101663 GTPBP1 0.42 5.3 0.31 2.39e-7 Menopause (age at onset); CESC cis rs11645898 0.810 rs11646364 chr16:72108687 A/T cg14768367 chr16:72042858 DHODH -0.81 -6.78 -0.38 7.74e-11 Blood protein levels; CESC cis rs2991971 0.776 rs12139364 chr1:45890155 T/C cg24296786 chr1:45957014 TESK2 0.58 8.21 0.45 9.72e-15 High light scatter reticulocyte count; CESC cis rs7949030 0.688 rs2849031 chr11:62365665 G/A cg02375832 chr11:62437615 C11orf48 0.36 5.2 0.3 3.99e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15933130 chr5:137089362 HNRNPA0 0.62 7.38 0.41 2.05e-12 Gut microbiome composition (summer); CESC cis rs858239 0.601 rs2141307 chr7:23191424 G/C cg23682824 chr7:23144976 KLHL7 0.43 5.38 0.31 1.61e-7 Cerebrospinal fluid biomarker levels; CESC cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg25019033 chr10:957182 NA -0.57 -6.13 -0.35 3.22e-9 Eosinophil percentage of granulocytes; CESC trans rs459571 0.629 rs441233 chr9:136876021 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.77 10.52 0.54 7.2e-22 Platelet distribution width; CESC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg23803603 chr1:2058230 PRKCZ 0.32 5.67 0.33 3.8e-8 Height; CESC cis rs2072499 0.750 rs57056972 chr1:156159064 C/A cg24450063 chr1:156163899 SLC25A44 0.98 11.99 0.59 9.64e-27 Testicular germ cell tumor; CESC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg23758822 chr17:41437982 NA 1.04 15.84 0.7 3.15e-40 Menopause (age at onset); CESC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.02 0.52 2.97e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6570726 0.935 rs419850 chr6:145827281 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.21e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6500395 1.000 rs1872655 chr16:48670883 A/C cg04672837 chr16:48644449 N4BP1 0.51 6.43 0.37 6.06e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg10578991 chr7:12443926 VWDE -0.41 -5.48 -0.32 1.01e-7 Coronary artery disease; CESC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg06456125 chr7:65229604 NA -0.4 -5.36 -0.31 1.84e-7 Aortic root size; CESC cis rs9916302 0.610 rs11078902 chr17:37631883 C/G cg15445000 chr17:37608096 MED1 0.41 6.77 0.38 8.24e-11 Glomerular filtration rate (creatinine); CESC cis rs589448 0.902 rs315124 chr12:69771727 G/A cg20891283 chr12:69753455 YEATS4 0.98 16.88 0.72 6.74e-44 Cerebrospinal fluid biomarker levels; CESC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg16049864 chr8:95962084 TP53INP1 -0.65 -11.35 -0.57 1.31e-24 Type 2 diabetes; CESC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg22535103 chr8:58192502 C8orf71 -0.78 -8.81 -0.48 1.69e-16 Developmental language disorder (linguistic errors); CESC cis rs7772486 0.754 rs697055 chr6:146003790 C/G cg05347473 chr6:146136440 FBXO30 0.51 6.05 0.35 5.03e-9 Lobe attachment (rater-scored or self-reported); CESC cis rs9915657 0.870 rs4140902 chr17:70133750 A/G cg09344028 chr17:70110421 NA 0.35 6.16 0.35 2.71e-9 Thyroid hormone levels; CESC cis rs611744 0.870 rs2212703 chr8:109198401 G/C cg21045802 chr8:109455806 TTC35 0.47 5.7 0.33 3.26e-8 Dupuytren's disease; CESC cis rs9916302 0.904 rs12452880 chr17:37591149 G/C cg15445000 chr17:37608096 MED1 0.41 6.81 0.39 6.45e-11 Glomerular filtration rate (creatinine); CESC cis rs6831352 0.959 rs6848050 chr4:100053733 T/C cg13256891 chr4:100009986 ADH5 0.73 8.48 0.46 1.62e-15 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03317280 chr1:228675123 RNF187 0.57 6.14 0.35 2.92e-9 Gut microbiome composition (summer); CESC cis rs1707322 0.963 rs10890371 chr1:46390897 T/G cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg09060608 chr5:178986726 RUFY1 0.43 6.23 0.36 1.82e-9 Lung cancer; CESC cis rs2070677 0.736 rs4498943 chr10:135422505 A/T cg20169779 chr10:135381914 SYCE1 0.79 8.91 0.48 8.63e-17 Gout; CESC cis rs2731664 0.819 rs449351 chr5:176872591 T/C cg23176889 chr5:176863531 GRK6 -0.65 -11.37 -0.57 1.17e-24 Intelligence (multi-trait analysis); CESC trans rs9467711 0.606 rs66823108 chr6:26377939 G/A cg06606381 chr12:133084897 FBRSL1 -0.74 -6.44 -0.37 5.45e-10 Autism spectrum disorder or schizophrenia; CESC cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg03433033 chr1:76189801 ACADM 0.68 8.2 0.45 1.06e-14 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9916302 0.904 rs10221223 chr17:37489100 T/G cg20243544 chr17:37824526 PNMT -0.46 -5.63 -0.33 4.6e-8 Glomerular filtration rate (creatinine); CESC cis rs11190604 1.000 rs7100386 chr10:102301417 C/T cg07080220 chr10:102295463 HIF1AN 0.66 6.04 0.35 5.08e-9 Palmitoleic acid (16:1n-7) levels; CESC cis rs1707322 1.000 rs7519181 chr1:46387829 G/C cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg23758822 chr17:41437982 NA 1.03 15.87 0.7 2.47e-40 Menopause (age at onset); CESC cis rs2295359 0.824 rs4655679 chr1:67599657 A/G cg17031739 chr1:67600172 NA -0.45 -6.21 -0.36 2e-9 Psoriasis; CESC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 11.97 0.59 1.14e-26 Alzheimer's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06713297 chr1:242011104 EXO1 0.52 6.77 0.38 8.21e-11 Gut microbiota (bacterial taxa); CESC cis rs5753618 0.539 rs695438 chr22:31811876 G/C cg02404636 chr22:31891804 SFI1 0.41 6.11 0.35 3.61e-9 Colorectal cancer; CESC cis rs2154427 0.938 rs2833967 chr21:34191308 G/A cg03746930 chr21:34165763 C21orf62;C21orf49 -0.52 -5.26 -0.31 2.94e-7 Bilirubin levels; CESC trans rs6084875 0.600 rs2093387 chr20:4724223 C/A cg10192164 chr16:30419175 ZNF771 -0.51 -6.18 -0.35 2.46e-9 Systemic lupus erythematosus; CESC cis rs2235544 0.565 rs664848 chr1:54468321 C/T cg25741118 chr1:54482237 LDLRAD1 0.23 5.66 0.33 4.02e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs7828089 0.715 rs11136029 chr8:22253485 A/G cg12081754 chr8:22256438 SLC39A14 -0.57 -8.35 -0.46 3.79e-15 Verbal declarative memory; CESC cis rs2075371 0.897 rs12667905 chr7:134000812 A/C cg00033643 chr7:134001901 SLC35B4 0.41 5.26 0.31 2.91e-7 Mean platelet volume; CESC cis rs3820928 0.874 rs7563644 chr2:227846932 A/G cg11843606 chr2:227700838 RHBDD1 -0.45 -5.81 -0.34 1.77e-8 Pulmonary function; CESC cis rs7474896 0.559 rs1212108 chr10:38094322 A/C cg25427524 chr10:38739819 LOC399744 -0.48 -5.16 -0.3 4.76e-7 Obesity (extreme); CESC cis rs17818399 0.962 rs7565274 chr2:46841861 G/T cg06386533 chr2:46925753 SOCS5 0.49 5.66 0.33 3.97e-8 Height; CESC cis rs9308731 0.591 rs10439381 chr2:111936459 A/G cg04202892 chr2:111875749 ACOXL 0.41 5.66 0.33 3.94e-8 Chronic lymphocytic leukemia; CESC cis rs12681366 0.564 rs2165405 chr8:95454307 A/T cg13257157 chr8:95487014 RAD54B 0.43 5.14 0.3 5.45e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg05754148 chr16:3507555 NAT15 0.57 8.63 0.47 5.67e-16 Tuberculosis; CESC trans rs10435719 0.753 rs9694940 chr8:11789858 G/C cg15556689 chr8:8085844 FLJ10661 0.52 6.49 0.37 4.16e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC cis rs78456975 0.527 rs11885279 chr2:1560633 T/C cg26248373 chr2:1572462 NA -0.58 -6.93 -0.39 3.29e-11 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg07697082 chr8:82753677 SNX16 0.37 5.18 0.3 4.36e-7 Diastolic blood pressure; CESC cis rs8077577 0.945 rs8069094 chr17:18096528 C/T cg16794390 chr17:18148240 FLII 0.42 5.87 0.34 1.32e-8 Obesity-related traits; CESC cis rs7582720 1.000 rs72936847 chr2:203774748 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22542702 chr2:132384461 NA -0.47 -6.59 -0.38 2.42e-10 Gut microbiome composition (summer); CESC cis rs7312774 0.748 rs4964191 chr12:107306497 G/A cg16260113 chr12:107380972 MTERFD3 0.64 6.13 0.35 3.11e-9 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13942016 chr11:47447463 PSMC3 0.6 7.51 0.42 8.99e-13 Gut microbiome composition (summer); CESC cis rs9929218 0.954 rs10163398 chr16:68823124 C/G cg02972257 chr16:68554789 NA 0.45 5.39 0.31 1.58e-7 Colorectal cancer; CESC trans rs2727020 1.000 rs2727020 chr11:49111407 C/G cg15704280 chr7:45808275 SEPT13 0.77 10.53 0.54 6.76e-22 Coronary artery disease; CESC cis rs36051895 0.632 rs10815171 chr9:5172567 G/A cg02405213 chr9:5042618 JAK2 -0.51 -6.41 -0.37 6.63e-10 Pediatric autoimmune diseases; CESC cis rs3768617 0.510 rs4491025 chr1:183065183 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 14.24 0.66 1.45e-34 Fuchs's corneal dystrophy; CESC cis rs9543976 0.920 rs9543972 chr13:76121675 T/C cg01531495 chr13:76123901 UCHL3 0.5 5.14 0.3 5.41e-7 Diabetic retinopathy; CESC cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.14 0.35 3.06e-9 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09516144 chr16:15982637 C16orf63 0.62 6.96 0.39 2.69e-11 Gut microbiome composition (summer); CESC cis rs2576037 0.796 rs6507718 chr18:44581284 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.45 5.88 0.34 1.24e-8 Personality dimensions; CESC cis rs9911578 0.967 rs9894274 chr17:56977919 G/A cg12560992 chr17:57184187 TRIM37 0.93 15.26 0.68 3.55e-38 Intelligence (multi-trait analysis); CESC cis rs1790761 0.505 rs7927657 chr11:67346988 T/C cg14500267 chr11:67383377 NA -0.31 -5.12 -0.3 5.81e-7 Mean corpuscular volume; CESC trans rs1814175 0.935 rs1827017 chr11:49632592 C/G cg15704280 chr7:45808275 SEPT13 -1.0 -17.77 -0.74 4.61e-47 Height; CESC cis rs7208859 0.623 rs216436 chr17:28922900 G/A cg19761014 chr17:28927070 LRRC37B2 0.88 6.7 0.38 1.22e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7089973 0.525 rs11196945 chr10:116600424 G/A cg25233709 chr10:116636983 FAM160B1 0.38 6.08 0.35 4.13e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg01341218 chr17:43662625 NA -0.86 -10.66 -0.55 2.59e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs28830936 0.510 rs12440605 chr15:42102285 A/G cg17847044 chr15:42102381 MAPKBP1 0.43 7.48 0.42 1.12e-12 Diastolic blood pressure; CESC cis rs4711336 0.935 rs3818525 chr6:33660779 A/G cg14003231 chr6:33640908 ITPR3 0.31 5.29 0.31 2.56e-7 Height; CESC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg24829409 chr8:58192753 C8orf71 -0.5 -6.08 -0.35 4.13e-9 Developmental language disorder (linguistic errors); CESC trans rs55704346 0.534 rs17605302 chr4:25396907 C/T cg01822600 chr1:245751692 KIF26B 0.42 6.12 0.35 3.41e-9 Tonsillectomy; CESC cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg17366294 chr4:99064904 C4orf37 0.6 8.39 0.46 2.99e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7264396 0.635 rs6058363 chr20:34505054 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.7 -9.89 -0.52 7.98e-20 Total cholesterol levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24034412 chr19:49122294 RPL18;SPHK2 0.59 7.22 0.41 5.37e-12 Gut microbiome composition (summer); CESC cis rs7772486 0.654 rs702321 chr6:146006695 A/G cg23711669 chr6:146136114 FBXO30 -0.9 -13.01 -0.62 2.84e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 5.84 0.34 1.49e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs1595825 0.891 rs2045244 chr2:198506466 C/T cg10820045 chr2:198174542 NA 0.42 5.15 0.3 5.02e-7 Ulcerative colitis; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg02685945 chr6:22570146 HDGFL1 -0.53 -6.7 -0.38 1.26e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9611565 0.879 rs4820437 chr22:41761290 T/C cg03806693 chr22:41940476 POLR3H -0.73 -8.87 -0.48 1.12e-16 Vitiligo; CESC cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.94e-9 Extrinsic epigenetic age acceleration; CESC cis rs9911578 0.967 rs4132925 chr17:56938016 C/G cg05425664 chr17:57184151 TRIM37 0.49 6.83 0.39 5.89e-11 Intelligence (multi-trait analysis); CESC trans rs7839040 0.698 rs4529421 chr8:82921979 A/G cg14472086 chr9:107730925 NA -0.49 -6.4 -0.37 6.9e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs9929218 0.679 rs9924886 chr16:68743939 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -10.18 -0.53 9.51e-21 Colorectal cancer; CESC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg24549020 chr5:56110836 MAP3K1 0.64 7.41 0.41 1.65e-12 Initial pursuit acceleration; CESC cis rs362272 0.524 rs10937924 chr4:3374898 T/C cg08886695 chr4:3369023 RGS12 -0.39 -5.4 -0.31 1.48e-7 Serum sulfate level; CESC cis rs9309473 1.000 rs10169714 chr2:73808773 T/G cg20560298 chr2:73613845 ALMS1 -0.54 -7.03 -0.4 1.71e-11 Metabolite levels; CESC cis rs10789491 0.951 rs35050319 chr1:47103886 C/A cg15501359 chr1:47185051 KIAA0494 -0.77 -8.1 -0.45 2.02e-14 Response to hepatitis C treatment; CESC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg00784671 chr22:46762841 CELSR1 -0.52 -5.49 -0.32 9.2e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7202877 0.706 rs37602 chr16:75505046 C/T cg04384234 chr16:75411784 CFDP1 0.46 5.5 0.32 9e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs9796 0.870 rs4244584 chr15:41259523 A/G cg18705301 chr15:41695430 NDUFAF1 0.39 5.89 0.34 1.19e-8 Menopause (age at onset); CESC cis rs2797160 1.000 rs4897152 chr6:126002400 A/G cg05901451 chr6:126070800 HEY2 -0.46 -6.62 -0.38 1.94e-10 Endometrial cancer; CESC cis rs61996546 0.622 rs12900771 chr15:26835235 G/A cg15066197 chr15:26874202 GABRB3 -0.35 -5.07 -0.3 7.55e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg12963246 chr6:28129442 ZNF389 0.6 8.3 0.45 5.21e-15 Depression; CESC cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg14345882 chr6:26364793 BTN3A2 0.41 5.36 0.31 1.78e-7 Intelligence (multi-trait analysis); CESC cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg03709012 chr19:19516395 GATAD2A 0.93 13.21 0.63 6e-31 Tonsillectomy; CESC cis rs4474465 0.688 rs7927494 chr11:78280578 G/A cg27205649 chr11:78285834 NARS2 0.49 6.27 0.36 1.47e-9 Alzheimer's disease (survival time); CESC cis rs7662987 0.517 rs2851260 chr4:100033574 C/T cg12011299 chr4:100065546 ADH4 0.6 6.56 0.37 2.83e-10 Smoking initiation; CESC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg18876405 chr7:65276391 NA -0.5 -5.91 -0.34 1.05e-8 Aortic root size; CESC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.09 13.26 0.63 4.06e-31 Gut microbiome composition (summer); CESC cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg26769984 chr7:1090371 C7orf50 0.65 7.25 0.41 4.53e-12 Bronchopulmonary dysplasia; CESC cis rs7927592 0.673 rs498782 chr11:68275851 A/G cg01657329 chr11:68192670 LRP5 -0.48 -6.37 -0.36 8.48e-10 Total body bone mineral density; CESC cis rs67311347 1.000 rs954589 chr3:40444545 C/T cg24209194 chr3:40518798 ZNF619 0.51 6.42 0.37 6.35e-10 Renal cell carcinoma; CESC cis rs826838 0.967 rs7965656 chr12:38807244 G/A cg13010199 chr12:38710504 ALG10B 0.6 8.24 0.45 8.03e-15 Heart rate; CESC cis rs483180 0.512 rs597308 chr1:120214953 G/A cg19096424 chr1:120255104 PHGDH 0.42 5.13 0.3 5.49e-7 Macular telangiectasia type 2; CESC cis rs2635047 0.967 rs2684843 chr18:44726260 T/A cg24371990 chr18:44770781 NA 0.34 5.39 0.31 1.58e-7 Educational attainment; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg14965979 chr2:44588995 PREPL;C2orf34 -0.46 -6.0 -0.35 6.46e-9 Fibrinogen levels; CESC cis rs2066819 1.000 rs77032009 chr12:56679971 A/G cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs2204008 0.536 rs12368354 chr12:38042798 G/A cg26384229 chr12:38710491 ALG10B 0.75 10.72 0.55 1.61e-22 Bladder cancer; CESC cis rs72781680 1.000 rs56205282 chr2:24221317 C/T cg08917208 chr2:24149416 ATAD2B 1.1 9.67 0.51 3.96e-19 Lymphocyte counts; CESC cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC cis rs10883723 0.810 rs2296582 chr10:104244139 G/T ch.10.2196322F chr10:104248062 ACTR1A 0.43 5.43 0.32 1.29e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs2463822 0.583 rs17709552 chr11:62040519 A/G cg06239285 chr11:62104954 ASRGL1 -1.06 -8.68 -0.47 4.09e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs73001065 0.711 rs58489806 chr19:19456917 C/T cg03709012 chr19:19516395 GATAD2A 0.99 6.91 0.39 3.51e-11 LDL cholesterol; CESC cis rs7195044 0.538 rs78001411 chr16:7267998 C/T cg07283511 chr16:7352896 A2BP1 -0.76 -5.32 -0.31 2.2e-7 Brain volume in infants (cerebrospinal fluid); CESC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg11905131 chr22:24372483 LOC391322 -0.72 -10.56 -0.54 5.46e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg26338869 chr17:61819248 STRADA 0.64 8.7 0.47 3.66e-16 Prudent dietary pattern; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15351736 chr11:111808104 DIXDC1 0.55 7.59 0.42 5.58e-13 Systemic lupus erythematosus; CESC cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg20701182 chr2:24300061 SF3B14 0.94 10.48 0.54 1.01e-21 Lymphocyte counts; CESC cis rs2070488 0.965 rs1046048 chr3:38524742 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.94 17.48 0.73 5.01e-46 Electrocardiographic conduction measures; CESC trans rs4950322 0.580 rs972368 chr1:146582724 C/G cg04954894 chr8:38089920 DDHD2 -0.59 -6.23 -0.36 1.82e-9 Protein quantitative trait loci; CESC cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.79 8.31 0.45 5.17e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs958025 1 rs958025 chr15:78759348 C/T cg24631222 chr15:78858424 CHRNA5 0.64 7.58 0.42 5.76e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CESC cis rs7246865 0.906 rs11666569 chr19:17214073 A/G cg19418318 chr19:17219073 MYO9B -0.35 -5.94 -0.34 9e-9 Reticulocyte fraction of red cells; CESC cis rs2845885 0.744 rs56271783 chr11:64004723 G/C cg24431193 chr11:63883947 FLRT1;MACROD1 0.79 5.1 0.3 6.56e-7 Body mass index; CESC cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs8005677 0.828 rs2295682 chr14:23374862 C/T cg01529538 chr14:23388837 RBM23 0.43 5.78 0.33 2.08e-8 Cognitive ability (multi-trait analysis); CESC cis rs7208859 0.725 rs6505215 chr17:29189903 C/A cg19761014 chr17:28927070 LRRC37B2 0.57 5.71 0.33 2.96e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2243480 0.708 rs35310401 chr7:65390359 A/G cg25894440 chr7:65020034 NA -0.59 -5.07 -0.3 7.57e-7 Diabetic kidney disease; CESC cis rs2236918 1.000 rs1635515 chr1:242017009 A/G cg17736920 chr1:242011382 EXO1 0.74 10.16 0.53 1.04e-20 Menopause (age at onset); CESC cis rs6815814 0.950 rs5743565 chr4:38805983 T/C cg02016764 chr4:38805732 TLR1 -0.63 -7.26 -0.41 4.22e-12 Breast cancer; CESC cis rs11958404 0.932 rs56204919 chr5:157431084 C/T cg05962755 chr5:157440814 NA 0.62 6.56 0.37 2.74e-10 IgG glycosylation; CESC cis rs2243480 1.000 rs35421653 chr7:65363429 C/A cg25894440 chr7:65020034 NA -0.61 -5.12 -0.3 5.87e-7 Diabetic kidney disease; CESC cis rs2073300 0.609 rs17757228 chr20:23351288 A/T cg16736954 chr20:23401023 NAPB 0.77 5.74 0.33 2.6e-8 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs2806561 0.704 rs2746560 chr1:23526279 G/A cg12483005 chr1:23474871 LUZP1 0.43 6.55 0.37 2.93e-10 Height; CESC cis rs8016982 0.633 rs7160342 chr14:81713427 G/C cg01989461 chr14:81687754 GTF2A1 0.72 11.27 0.57 2.52e-24 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02266452 chr11:82905235 ANKRD42 0.57 6.17 0.35 2.59e-9 Gut microbiome composition (summer); CESC cis rs9300255 0.602 rs1790095 chr12:123681222 G/A cg05973401 chr12:123451056 ABCB9 0.49 5.44 0.32 1.2e-7 Neutrophil percentage of white cells; CESC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg02034447 chr16:89574710 SPG7 0.43 5.2 0.3 4.09e-7 Multiple myeloma (IgH translocation); CESC cis rs10791323 0.572 rs10750551 chr11:133737462 G/A cg03690763 chr11:133734501 NA -0.31 -5.14 -0.3 5.36e-7 Childhood ear infection; CESC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7267979 0.866 rs2424698 chr20:25256106 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 15.24 0.68 4.21e-38 Liver enzyme levels (alkaline phosphatase); CESC cis rs3105593 1.000 rs11070805 chr15:50964192 G/A cg08437265 chr15:50716283 USP8 0.45 5.93 0.34 9.66e-9 QT interval; CESC cis rs4704187 0.687 rs6894048 chr5:74456838 A/G cg03227963 chr5:74354835 NA 0.3 5.49 0.32 9.27e-8 Response to amphetamines; CESC cis rs8099014 0.906 rs4940693 chr18:56101171 T/G cg19312305 chr18:56117016 MIR122 -0.3 -5.55 -0.32 6.75e-8 Platelet count; CESC cis rs7818345 0.967 rs6999786 chr8:19277817 G/A cg11303988 chr8:19266685 CSGALNACT1 0.34 6.25 0.36 1.64e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs916888 0.821 rs199514 chr17:44856881 G/A cg15921436 chr17:44337874 NA -0.72 -7.88 -0.44 8.53e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3858526 0.755 rs10769368 chr11:5962084 C/T cg13902645 chr11:5959945 NA 0.48 6.02 0.35 5.9e-9 DNA methylation (variation); CESC cis rs1552244 0.748 rs9862221 chr3:10059658 G/T cg08888203 chr3:10149979 C3orf24 0.51 6.21 0.36 2.07e-9 Alzheimer's disease; CESC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.54 6.07 0.35 4.34e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6496667 0.779 rs2107436 chr15:91042921 A/T cg13834112 chr15:90361639 NA 0.4 5.31 0.31 2.27e-7 Rheumatoid arthritis; CESC cis rs17376456 1.000 rs9968749 chr5:93509559 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.6 5.05 0.3 8.13e-7 Diabetic retinopathy; CESC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg06600287 chr1:53387719 ECHDC2 -0.27 -5.05 -0.3 8.13e-7 Monocyte count; CESC cis rs698833 0.886 rs698775 chr2:44588941 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.56 7.11 0.4 1.07e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs74781061 1.000 rs6495117 chr15:74899500 T/C cg17294928 chr15:75287854 SCAMP5 -0.51 -5.46 -0.32 1.11e-7 Endometriosis; CESC cis rs7107174 1.000 rs2512544 chr11:77986371 A/T cg02023728 chr11:77925099 USP35 0.47 6.49 0.37 4.19e-10 Testicular germ cell tumor; CESC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg12463550 chr7:65579703 CRCP -0.49 -6.21 -0.36 2.06e-9 Aortic root size; CESC cis rs2073300 0.609 rs3827086 chr20:23357331 C/T cg12062639 chr20:23401060 NAPB 1.08 8.67 0.47 4.32e-16 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4268898 1.000 rs10165445 chr2:24441698 C/T cg06627628 chr2:24431161 ITSN2 0.66 8.08 0.44 2.26e-14 Asthma; CESC cis rs763121 0.853 rs5757211 chr22:39051705 C/T cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg20744362 chr22:50050164 C22orf34 0.46 7.99 0.44 4.04e-14 Monocyte count;Monocyte percentage of white cells; CESC cis rs34734847 0.787 rs695948 chr12:121149596 A/G cg21892295 chr12:121157589 UNC119B -0.4 -6.43 -0.37 5.96e-10 Mean corpuscular volume; CESC cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg24110177 chr3:50126178 RBM5 0.52 7.18 0.4 6.85e-12 Intelligence (multi-trait analysis); CESC cis rs2120019 1.000 rs12185102 chr15:75352201 G/A cg17294928 chr15:75287854 SCAMP5 -0.65 -7.04 -0.4 1.67e-11 Blood trace element (Zn levels); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg12732814 chr3:14220329 LSM3;XPC 0.47 6.11 0.35 3.54e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs5758659 0.652 rs133349 chr22:42428727 A/T cg15557168 chr22:42548783 NA -0.48 -7.54 -0.42 7.54e-13 Cognitive function; CESC cis rs9487051 0.676 rs6568568 chr6:109597048 C/T cg01475377 chr6:109611718 NA -0.45 -7.04 -0.4 1.6e-11 Reticulocyte fraction of red cells; CESC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg18876405 chr7:65276391 NA 0.44 6.02 0.35 5.82e-9 Aortic root size; CESC cis rs9549367 0.737 rs9549712 chr13:113902355 G/A cg00898013 chr13:113819073 PROZ -0.53 -7.21 -0.41 5.74e-12 Platelet distribution width; CESC cis rs8114671 0.967 rs4911478 chr20:33782625 A/C cg06115741 chr20:33292138 TP53INP2 -0.42 -5.11 -0.3 6.06e-7 Height; CESC cis rs7267979 0.764 rs2474767 chr20:25246733 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.09 0.65 4.79e-34 Liver enzyme levels (alkaline phosphatase); CESC cis rs372883 0.638 rs117213 chr21:30720536 G/A cg24692254 chr21:30365293 RNF160 -0.53 -6.67 -0.38 1.5e-10 Pancreatic cancer; CESC cis rs8180040 0.620 rs9844122 chr3:47108330 C/T cg27129171 chr3:47204927 SETD2 0.66 9.71 0.51 2.81e-19 Colorectal cancer; CESC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg13770153 chr20:60521292 NA -0.44 -5.7 -0.33 3.2e-8 Body mass index; CESC cis rs10927875 0.562 rs10803401 chr1:16147377 G/A cg18973939 chr1:16164122 FLJ37453 0.38 5.66 0.33 3.9e-8 Dilated cardiomyopathy; CESC cis rs116095464 0.558 rs9688045 chr5:254035 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.51 5.28 0.31 2.76e-7 Breast cancer; CESC trans rs650950 0.528 rs646660 chr11:35528452 C/T cg19905880 chr11:67049324 ADRBK1 -0.47 -6.41 -0.37 6.63e-10 Bronchopulmonary dysplasia; CESC cis rs2637266 0.739 rs2583041 chr10:78439219 C/T cg18941641 chr10:78392320 NA -0.4 -7.36 -0.41 2.38e-12 Pulmonary function; CESC cis rs4889855 0.614 rs7208670 chr17:78494220 T/G cg16591659 chr17:78472290 NA -0.49 -6.84 -0.39 5.35e-11 Fractional excretion of uric acid; CESC cis rs67311347 1.000 rs11914297 chr3:40410070 T/C cg09455208 chr3:40491958 NA 0.52 8.83 0.48 1.45e-16 Renal cell carcinoma; CESC cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg04455712 chr21:45112962 RRP1B -0.36 -5.57 -0.32 6.4e-8 Mean corpuscular volume; CESC trans rs8057939 0.593 rs1437110 chr16:49404789 C/G cg15532236 chr6:170188124 NA -0.55 -6.43 -0.37 5.91e-10 Prostate cancer (SNP x SNP interaction); CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg17546822 chr22:41865178 ACO2;PHF5A 0.47 6.01 0.35 6.24e-9 Psoriatic arthritis; CESC cis rs2235544 0.565 rs681660 chr1:54471189 G/A cg25741118 chr1:54482237 LDLRAD1 0.23 5.88 0.34 1.25e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1580019 0.563 rs10486509 chr7:32585443 C/G cg07520158 chr7:32535189 LSM5;AVL9 -0.54 -6.65 -0.38 1.66e-10 Cognitive ability; CESC cis rs2439831 0.867 rs28461955 chr15:43661459 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.19 0.63 6.83e-31 Lung cancer in ever smokers; CESC cis rs12699921 0.935 rs6461363 chr7:17992150 A/T cg03009463 chr7:17980271 SNX13 0.42 5.45 0.32 1.16e-7 Fibrinogen levels; CESC cis rs4065321 0.522 rs34648856 chr17:38149411 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.6 8.97 0.48 5.57e-17 White blood cell count (basophil);White blood cell count; CESC cis rs7089973 0.584 rs4752255 chr10:116576790 C/T cg23260525 chr10:116636907 FAM160B1 0.38 6.97 0.39 2.57e-11 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs10899021 1.000 rs11236201 chr11:74375633 A/G cg25880958 chr11:74394337 NA -0.73 -6.74 -0.38 9.58e-11 Response to metformin (IC50); CESC cis rs2243480 1.000 rs34703416 chr7:65300642 A/G cg18252515 chr7:66147081 NA -1.06 -10.24 -0.53 6.08e-21 Diabetic kidney disease; CESC cis rs6430585 0.591 rs75223002 chr2:136525309 G/T cg07169764 chr2:136633963 MCM6 1.26 16.5 0.71 1.45e-42 Corneal structure; CESC cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7894051 1.000 rs11101721 chr10:135190358 C/G cg20534287 chr10:135191450 PAOX 0.51 5.12 0.3 5.94e-7 Lifespan; CESC cis rs986417 1.000 rs10130267 chr14:60944527 A/G cg00859478 chr14:60978094 SIX6 0.45 5.06 0.3 7.79e-7 Gut microbiota (bacterial taxa); CESC cis rs12410462 0.681 rs79461024 chr1:227568783 G/T cg23173402 chr1:227635558 NA 0.68 5.72 0.33 2.88e-8 Major depressive disorder; CESC cis rs10870270 1.000 rs7078692 chr10:133775370 T/A cg26149184 chr10:133730230 NA 0.38 5.14 0.3 5.22e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs3892630 0.878 rs66788054 chr19:33190146 G/T cg13157960 chr19:33183277 NUDT19 0.56 5.46 0.32 1.08e-7 Red blood cell traits; CESC cis rs6429082 0.749 rs291362 chr1:235686690 T/A cg26050004 chr1:235667680 B3GALNT2 0.66 8.77 0.47 2.23e-16 Adiposity; CESC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg21782813 chr7:2030301 MAD1L1 0.44 6.17 0.35 2.54e-9 Bipolar disorder and schizophrenia; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg19006050 chr10:131904236 NA 0.45 6.05 0.35 4.96e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1800469 1.000 rs1982072 chr19:41864509 T/A cg08477640 chr19:41863820 B9D2 0.63 8.38 0.46 3.16e-15 Colorectal cancer; CESC cis rs28829049 0.731 rs7537573 chr1:19373605 C/T cg13387374 chr1:19411106 UBR4 0.46 5.78 0.33 2.06e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs11696501 0.739 rs6104252 chr20:44254323 G/A cg11783356 chr20:44313418 WFDC10B -0.35 -5.42 -0.32 1.35e-7 Brain structure; CESC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg18016565 chr1:150552671 MCL1 0.33 5.16 0.3 4.85e-7 Tonsillectomy; CESC cis rs6582630 0.555 rs12828034 chr12:38274249 C/T cg26384229 chr12:38710491 ALG10B -0.46 -6.05 -0.35 4.85e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg09177884 chr7:1199841 ZFAND2A -0.5 -6.23 -0.36 1.83e-9 Longevity;Endometriosis; CESC cis rs644799 1.000 rs505220 chr11:95563228 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 14.27 0.66 1.19e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs950169 0.922 rs11630760 chr15:85113337 G/T cg17507749 chr15:85114479 UBE2QP1 0.54 6.11 0.35 3.61e-9 Schizophrenia; CESC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg24562669 chr7:97807699 LMTK2 0.48 7.1 0.4 1.13e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs17125944 0.505 rs10483617 chr14:53202605 A/G cg13660082 chr14:53194042 PSMC6 0.58 5.13 0.3 5.67e-7 Alzheimer's disease (late onset); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg16218377 chr11:34073324 CAPRIN1 -0.47 -6.31 -0.36 1.19e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2299587 0.762 rs62500086 chr8:17787808 T/A cg08627089 chr8:17753878 FGL1 -0.37 -5.13 -0.3 5.63e-7 Economic and political preferences; CESC cis rs7520050 0.966 rs4073846 chr1:46462881 C/T cg03146154 chr1:46216737 IPP 0.46 5.95 0.34 8.28e-9 Red blood cell count;Reticulocyte count; CESC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs61931739 0.559 rs4385974 chr12:34313128 G/C cg19457237 chr12:34500585 NA -0.42 -5.62 -0.33 4.83e-8 Morning vs. evening chronotype; CESC cis rs6580649 1.000 rs7305954 chr12:48403530 C/T cg24011408 chr12:48396354 COL2A1 0.38 5.09 0.3 6.71e-7 Lung cancer; CESC cis rs11864453 0.645 rs7194668 chr16:72128207 G/C cg16558253 chr16:72132732 DHX38 -0.53 -7.73 -0.43 2.27e-13 Fibrinogen levels; CESC cis rs9768139 0.935 rs116290351 chr7:158119712 T/A cg24154853 chr7:158122151 PTPRN2 -0.37 -5.8 -0.34 1.85e-8 Calcium levels; CESC cis rs2281558 0.876 rs6115135 chr20:25279878 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.62 8.38 0.46 3.08e-15 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC trans rs1814175 0.616 rs28417656 chr11:50040152 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -18.7 -0.75 2.39e-50 Height; CESC cis rs6570726 0.935 rs384806 chr6:145814889 C/G cg23711669 chr6:146136114 FBXO30 0.82 12.29 0.6 8.74e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7959452 0.535 rs11615712 chr12:69619736 A/T cg20891283 chr12:69753455 YEATS4 -0.7 -9.87 -0.52 9.11e-20 Blood protein levels; CESC cis rs35110281 0.837 rs12627667 chr21:45071396 A/C cg21573476 chr21:45109991 RRP1B -0.48 -6.7 -0.38 1.27e-10 Mean corpuscular volume; CESC cis rs68170813 0.559 rs10953530 chr7:106827796 A/C cg02696742 chr7:106810147 HBP1 -0.54 -5.09 -0.3 6.64e-7 Coronary artery disease; CESC trans rs11039798 0.512 rs1588069 chr11:48694871 A/G cg15704280 chr7:45808275 SEPT13 0.65 6.5 0.37 4.05e-10 Axial length; CESC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg08859206 chr1:53392774 SCP2 0.65 9.62 0.51 5.62e-19 Monocyte count; CESC cis rs826838 1.000 rs10875991 chr12:39108886 G/C cg13010199 chr12:38710504 ALG10B 0.58 8.08 0.44 2.24e-14 Heart rate; CESC cis rs637571 0.557 rs1204649 chr11:65702776 A/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.7 9.7 0.51 3.16e-19 Eosinophil percentage of white cells; CESC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg19592336 chr6:28129416 ZNF389 0.63 8.71 0.47 3.29e-16 Depression; CESC cis rs35110281 0.720 rs162375 chr21:44927015 C/T cg21573476 chr21:45109991 RRP1B 0.44 6.28 0.36 1.37e-9 Mean corpuscular volume; CESC cis rs763121 0.853 rs6001173 chr22:39015302 A/G cg06544989 chr22:39130855 UNC84B 0.5 9.14 0.49 1.65e-17 Menopause (age at onset); CESC cis rs7647973 1.000 rs2312462 chr3:49601255 A/G cg06212747 chr3:49208901 KLHDC8B 0.52 6.96 0.39 2.59e-11 Menarche (age at onset); CESC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg05564831 chr3:52568323 NT5DC2 0.46 7.38 0.41 2.06e-12 Bipolar disorder; CESC cis rs71403859 0.685 rs12927044 chr16:71930105 C/A cg08717414 chr16:71523259 ZNF19 -0.83 -5.2 -0.3 3.96e-7 Post bronchodilator FEV1; CESC cis rs6456156 0.846 rs10946211 chr6:167515489 G/A cg07741184 chr6:167504864 NA -0.35 -6.04 -0.35 5.2e-9 Primary biliary cholangitis; CESC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg16049864 chr8:95962084 TP53INP1 -0.6 -10.24 -0.53 5.78e-21 Type 2 diabetes; CESC cis rs113835537 0.935 rs15969 chr11:66394387 C/T cg24851651 chr11:66362959 CCS 0.62 5.6 0.33 5.26e-8 Airway imaging phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19385725 chr18:21166173 NPC1 0.6 6.86 0.39 4.84e-11 Gut microbiome composition (summer); CESC cis rs2204008 0.558 rs66545149 chr12:38204694 A/G cg13010199 chr12:38710504 ALG10B 0.53 6.43 0.37 5.94e-10 Bladder cancer; CESC cis rs7249142 0.526 rs7256811 chr19:19283551 A/G cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.29 5.21 0.3 3.75e-7 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15651152 chr8:141297750 TRAPPC9 -0.57 -6.28 -0.36 1.34e-9 Gut microbiome composition (summer); CESC cis rs16854884 0.657 rs35067746 chr3:143747147 T/A cg06585982 chr3:143692056 C3orf58 0.5 6.71 0.38 1.18e-10 Economic and political preferences (feminism/equality); CESC cis rs9287719 0.601 rs9287718 chr2:10701629 A/T cg00105475 chr2:10696890 NA -0.41 -5.61 -0.33 5.1e-8 Prostate cancer; CESC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg05564831 chr3:52568323 NT5DC2 0.46 7.22 0.41 5.37e-12 Bipolar disorder; CESC trans rs561341 0.769 rs9899093 chr17:30191954 C/G cg27661571 chr11:113659931 NA -0.65 -6.25 -0.36 1.66e-9 Hip circumference adjusted for BMI; CESC cis rs9715521 0.677 rs17493148 chr4:59861895 T/C cg11281224 chr4:60001000 NA -0.56 -7.71 -0.43 2.58e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs7943203 1.000 rs4754322 chr11:108311655 T/C cg01416241 chr5:148737479 PCYOX1L -0.48 -6.07 -0.35 4.52e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.7 10.93 0.56 3.27e-23 Personality dimensions; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg06110578 chr6:43597079 MAD2L1BP;GTPBP2 -0.47 -6.59 -0.38 2.38e-10 Gambling; CESC cis rs4481887 0.927 rs9651177 chr1:248445702 A/G cg00666640 chr1:248458726 OR2T12 0.33 5.81 0.34 1.83e-8 Common traits (Other); CESC cis rs7089973 0.604 rs3758603 chr10:116605368 T/C cg03647239 chr10:116582469 FAM160B1 0.43 5.35 0.31 1.94e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs4810685 0.509 rs8114940 chr20:46411490 T/C cg08288986 chr20:46415360 SULF2 0.51 5.81 0.34 1.75e-8 Attention deficit hyperactivity disorder (time to onset); CESC cis rs722599 0.683 rs10144845 chr14:75237770 C/T cg11812906 chr14:75593930 NEK9 0.4 5.08 0.3 7.15e-7 IgG glycosylation; CESC cis rs7647973 0.587 rs10452032 chr3:49680973 G/A cg07636037 chr3:49044803 WDR6 0.53 6.34 0.36 9.78e-10 Menarche (age at onset); CESC cis rs4664304 0.966 rs1397707 chr2:160760972 C/T cg03641300 chr2:160917029 PLA2R1 -0.46 -6.35 -0.36 9.12e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs818427 0.929 rs153550 chr5:112234957 C/T cg07820702 chr5:112228657 REEP5 -0.4 -5.06 -0.3 7.9e-7 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.57 -6.14 -0.35 3.05e-9 Gut microbiome composition (summer); CESC trans rs1814175 0.645 rs4598671 chr11:50003191 C/A cg11707556 chr5:10655725 ANKRD33B -0.42 -6.12 -0.35 3.32e-9 Height; CESC cis rs11690935 0.694 rs312921 chr2:172567225 T/C cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.72 -0.67 2.89e-36 Schizophrenia; CESC cis rs6831352 0.918 rs29001201 chr4:100053861 T/C cg13256891 chr4:100009986 ADH5 -0.77 -8.29 -0.45 5.73e-15 Alcohol dependence; CESC cis rs6748734 0.894 rs4675869 chr2:241827696 A/G cg07537917 chr2:241836409 C2orf54 -0.24 -5.05 -0.3 8.42e-7 Urinary metabolites; CESC cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg14345882 chr6:26364793 BTN3A2 0.41 5.12 0.3 5.79e-7 Intelligence (multi-trait analysis); CESC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg21770322 chr7:97807741 LMTK2 0.54 8.21 0.45 9.94e-15 Prostate cancer (SNP x SNP interaction); CESC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg08888203 chr3:10149979 C3orf24 0.49 6.29 0.36 1.3e-9 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04213338 chr7:6144367 USP42 0.59 6.88 0.39 4.42e-11 Gut microbiome composition (summer); CESC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg27170947 chr2:26402098 FAM59B -0.71 -8.11 -0.45 1.84e-14 Gut microbiome composition (summer); CESC cis rs2073300 1.000 rs78000067 chr20:23439507 A/G cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9399135 0.935 rs9376086 chr6:135371329 T/C cg22676075 chr6:135203613 NA 0.52 7.3 0.41 3.39e-12 Red blood cell count; CESC cis rs959260 0.557 rs12936583 chr17:73304710 A/C cg14668889 chr17:73230827 NUP85 0.39 5.38 0.31 1.6e-7 Systemic lupus erythematosus; CESC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg12373951 chr3:133503437 NA 0.39 5.53 0.32 7.86e-8 Iron status biomarkers; CESC cis rs12586317 0.547 rs60152856 chr14:35421373 G/A cg16230307 chr14:35515116 FAM177A1 0.96 10.36 0.54 2.4e-21 Psoriasis; CESC cis rs2439831 0.850 rs28684672 chr15:44107662 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.65 5.9 0.34 1.13e-8 Lung cancer in ever smokers; CESC cis rs71636778 0.543 rs17162333 chr1:27236757 C/G cg12203394 chr1:27248618 NUDC 0.66 5.55 0.32 6.85e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CESC cis rs7084402 0.934 rs1658426 chr10:60331542 A/T cg07615347 chr10:60278583 BICC1 0.59 9.22 0.49 9.62e-18 Refractive error; CESC cis rs13343954 0.518 rs2216594 chr19:33533258 G/A cg17764715 chr19:33622953 WDR88 0.54 7.23 0.41 5.16e-12 Colorectal cancer; CESC cis rs793571 0.669 rs28864995 chr15:58945671 T/G cg05156742 chr15:59063176 FAM63B 0.63 8.45 0.46 1.94e-15 Schizophrenia; CESC cis rs3820068 0.581 rs2861387 chr1:15951296 G/A cg13390004 chr1:15929781 NA 0.37 5.8 0.34 1.9e-8 Systolic blood pressure; CESC cis rs117623576 0.941 rs67225815 chr10:32408946 C/T cg03047570 chr10:32398778 NA -0.76 -7.88 -0.44 8.62e-14 Anti-saccade response; CESC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17522466 chr8:23386187 SLC25A37 -0.55 -6.07 -0.35 4.34e-9 Gut microbiome composition (summer); CESC cis rs11676348 0.818 rs7425447 chr2:218980183 T/C cg00012203 chr2:219082015 ARPC2 -0.57 -7.47 -0.42 1.14e-12 Ulcerative colitis; CESC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 13.04 0.63 2.35e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs79349575 0.715 rs1058018 chr17:47000251 C/T cg16584676 chr17:46985605 UBE2Z 0.66 8.83 0.48 1.49e-16 Type 2 diabetes; CESC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg04267008 chr7:1944627 MAD1L1 -0.74 -10.0 -0.52 3.37e-20 Bipolar disorder and schizophrenia; CESC cis rs9814567 0.762 rs13071852 chr3:134223217 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.44 5.68 0.33 3.53e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs11098499 0.954 rs17006190 chr4:120418838 C/G cg24375607 chr4:120327624 NA 0.48 5.97 0.34 7.47e-9 Corneal astigmatism; CESC cis rs4780401 0.573 rs8045673 chr16:11804385 C/A cg01061890 chr16:11836724 TXNDC11 -0.56 -7.65 -0.43 3.84e-13 Rheumatoid arthritis; CESC cis rs8033133 0.957 rs3742952 chr15:25351026 A/G cg14481604 chr15:25334117 SNORD116-22 -0.38 -5.67 -0.33 3.69e-8 Blood osmolality (transformed sodium); CESC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.56 -7.1 -0.4 1.14e-11 Bipolar disorder; CESC cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg20503657 chr10:835505 NA 1.1 10.47 0.54 1.12e-21 Eosinophil percentage of granulocytes; CESC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg26528311 chr1:38462546 FHL3 -0.35 -5.26 -0.31 2.95e-7 Coronary artery disease; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg01485165 chr20:49411421 BCAS4 0.45 6.34 0.36 1.01e-9 Systemic lupus erythematosus; CESC cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 5.87 0.34 1.28e-8 Tonsillectomy; CESC cis rs748404 0.690 rs1079309 chr15:43783164 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.35 0.41 2.53e-12 Lung cancer; CESC cis rs7605827 0.930 rs11679632 chr2:15605659 G/A cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs8058578 1.000 rs8058578 chr16:30726248 C/T cg00531865 chr16:30841666 NA -0.43 -5.62 -0.33 4.95e-8 Multiple myeloma; CESC trans rs11098499 0.954 rs66506550 chr4:120371445 T/A cg25214090 chr10:38739885 LOC399744 0.7 9.92 0.52 6.5e-20 Corneal astigmatism; CESC cis rs2732480 0.577 rs2634681 chr12:48733084 C/T cg04545296 chr12:48745243 ZNF641 -0.34 -5.98 -0.34 7.35e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7649275 0.882 rs2612025 chr3:53778314 T/C cg21503701 chr3:53781065 CACNA1D -0.38 -5.08 -0.3 7.14e-7 Trans fatty acid levels; CESC cis rs17253792 0.822 rs28513551 chr14:56094993 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg24642844 chr7:1081250 C7orf50 -0.75 -9.1 -0.49 2.29e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs933688 0.938 rs6869048 chr5:90664322 G/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.16 15.56 0.69 3.24e-39 Smoking behavior; CESC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg04369109 chr6:150039330 LATS1 -0.39 -5.38 -0.31 1.62e-7 Lung cancer; CESC cis rs75477785 1.000 rs12064211 chr1:210050518 A/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.79 5.15 0.3 5.08e-7 Cleft lip with or without cleft palate; CESC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg22920501 chr2:26401640 FAM59B -0.64 -7.7 -0.43 2.73e-13 Gut microbiome composition (summer); CESC cis rs6032067 0.714 rs35770435 chr20:43788804 C/T cg10761708 chr20:43804764 PI3 0.54 6.31 0.36 1.14e-9 Blood protein levels; CESC cis rs2243480 1.000 rs316330 chr7:65605372 C/A cg13147721 chr7:65941812 NA -0.97 -9.14 -0.49 1.7e-17 Diabetic kidney disease; CESC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg04287289 chr16:89883240 FANCA 0.88 14.55 0.67 1.23e-35 Vitiligo; CESC cis rs116095464 0.558 rs62346526 chr5:220614 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.74 0.33 2.63e-8 Breast cancer; CESC cis rs10463316 0.784 rs906678 chr5:150779040 T/C cg03212797 chr5:150827313 SLC36A1 -0.44 -5.54 -0.32 7.2e-8 Metabolite levels (Pyroglutamine); CESC cis rs258892 0.895 rs155432 chr5:72138608 G/T cg21869765 chr5:72125136 TNPO1 0.44 5.68 0.33 3.61e-8 Small cell lung carcinoma; CESC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg22532736 chr15:64126641 HERC1 0.47 6.03 0.35 5.55e-9 Breast cancer;Type 2 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22541143 chr4:84377292 HELQ;MRPS18C -0.45 -6.47 -0.37 4.75e-10 Fibrinogen levels; CESC cis rs7914558 1.000 rs7914558 chr10:104775908 G/A cg04362960 chr10:104952993 NT5C2 0.43 5.77 0.33 2.19e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12681288 0.782 rs12549337 chr8:1030187 A/G cg04851639 chr8:1020857 NA -0.42 -8.67 -0.47 4.48e-16 Schizophrenia; CESC cis rs950027 0.620 rs1617984 chr15:45622662 A/G cg21132104 chr15:45694354 SPATA5L1 0.67 8.6 0.47 7.08e-16 Response to fenofibrate (adiponectin levels); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg00902396 chr2:135679280 CCNT2 0.48 7.03 0.4 1.8e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg11663144 chr21:46675770 NA -0.64 -10.05 -0.53 2.34e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg02951883 chr7:2050386 MAD1L1 0.41 5.58 0.32 5.89e-8 Bipolar disorder and schizophrenia; CESC trans rs2075371 0.932 rs1862048 chr7:133978167 C/G cg10929213 chr11:66056787 YIF1A 0.53 6.18 0.35 2.42e-9 Mean platelet volume; CESC cis rs863345 0.604 rs949398 chr1:158461983 A/G cg12129480 chr1:158549410 OR10X1 -0.36 -7.29 -0.41 3.49e-12 Pneumococcal bacteremia; CESC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.46 5.36 0.31 1.77e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10779751 0.770 rs11121696 chr1:11238063 A/G cg08854313 chr1:11322531 MTOR -0.7 -8.35 -0.46 3.95e-15 Body mass index; CESC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg24531977 chr5:56204891 C5orf35 -0.43 -5.42 -0.32 1.33e-7 Coronary artery disease; CESC cis rs4481887 0.800 rs10788780 chr1:248483598 G/A cg00666640 chr1:248458726 OR2T12 0.35 5.88 0.34 1.23e-8 Common traits (Other); CESC cis rs748404 0.631 rs3809482 chr15:43661802 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.56 8.8 0.48 1.82e-16 Lung cancer; CESC cis rs62244186 0.541 rs3804583 chr3:44884647 G/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.43 5.68 0.33 3.51e-8 Depressive symptoms; CESC cis rs9486715 0.867 rs1855533 chr6:97050265 T/C cg06623918 chr6:96969491 KIAA0776 -0.96 -15.13 -0.68 1.08e-37 Headache; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07398558 chr1:28879201 TRNAU1AP -0.49 -6.39 -0.37 7.34e-10 Asthma; CESC cis rs2637266 0.935 rs2583059 chr10:78395178 G/C cg18941641 chr10:78392320 NA 0.45 8.6 0.47 7.12e-16 Pulmonary function; CESC cis rs62244186 0.545 rs7640654 chr3:44763037 A/C cg15225532 chr3:44803084 KIF15;KIAA1143 0.48 6.29 0.36 1.33e-9 Depressive symptoms; CESC cis rs1461503 0.534 rs4293127 chr11:122804263 G/C cg27398637 chr11:122830231 C11orf63 -0.48 -6.66 -0.38 1.57e-10 Menarche (age at onset); CESC cis rs2228479 0.571 rs62052183 chr16:89966921 C/A cg00800038 chr16:89945340 TCF25 -0.84 -7.29 -0.41 3.49e-12 Skin colour saturation; CESC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.68 -8.7 -0.47 3.52e-16 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03849660 chr7:102098214 ALKBH4 -0.55 -6.52 -0.37 3.44e-10 Gut microbiome composition (summer); CESC cis rs2625529 0.689 rs10851847 chr15:72111760 T/C cg16672083 chr15:72433130 SENP8 -0.5 -7.3 -0.41 3.42e-12 Red blood cell count; CESC cis rs1008375 0.966 rs6449313 chr4:17588320 A/G cg16339924 chr4:17578868 LAP3 0.8 10.51 0.54 8.03e-22 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1499614 1.000 rs2659903 chr7:66180931 G/A cg12463550 chr7:65579703 CRCP 0.73 5.73 0.33 2.78e-8 Gout; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg03153775 chr3:45185028 CDCP1 0.43 6.15 0.35 2.81e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg25204440 chr1:209979598 IRF6 0.63 6.57 0.37 2.64e-10 Cleft lip with or without cleft palate; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05364211 chr1:213188787 ANGEL2 -0.52 -6.11 -0.35 3.58e-9 Ulcerative colitis; CESC cis rs6690583 0.623 rs55721024 chr1:85454447 A/C cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs2191566 0.639 rs7260075 chr19:44566766 T/C cg20607764 chr19:44506953 ZNF230 -0.44 -5.64 -0.33 4.34e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs16854884 0.710 rs1530479 chr3:143819653 C/T cg06585982 chr3:143692056 C3orf58 0.44 5.94 0.34 8.85e-9 Economic and political preferences (feminism/equality); CESC cis rs9457247 0.967 rs2757054 chr6:167380501 A/G cg23791538 chr6:167370224 RNASET2 0.6 8.56 0.47 9.4e-16 Crohn's disease; CESC cis rs2439831 0.867 rs2447196 chr15:43893818 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.68 -8.17 -0.45 1.25e-14 Lung cancer in ever smokers; CESC trans rs17508449 0.819 rs77551704 chr1:114235186 G/C cg23028848 chr11:57092561 TNKS1BP1 -0.79 -6.28 -0.36 1.38e-9 Leprosy; CESC cis rs2070997 0.607 rs13294646 chr9:133715206 C/G cg11464064 chr9:133710261 ABL1 0.68 7.26 0.41 4.36e-12 Response to amphetamines; CESC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg02951883 chr7:2050386 MAD1L1 -0.46 -5.85 -0.34 1.47e-8 Bipolar disorder and schizophrenia; CESC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg11890956 chr21:40555474 PSMG1 1.21 23.11 0.82 1.81e-65 Cognitive function; CESC cis rs6460942 0.915 rs62448620 chr7:12458170 C/T cg20607287 chr7:12443886 VWDE -0.78 -9.15 -0.49 1.61e-17 Coronary artery disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg16282910 chr9:112296723 NA -0.48 -6.52 -0.37 3.6e-10 Gut microbiota (bacterial taxa); CESC cis rs11249608 0.511 rs58827878 chr5:178481936 C/G cg01312482 chr5:178451176 ZNF879 -0.42 -5.31 -0.31 2.34e-7 Pubertal anthropometrics; CESC cis rs6912958 0.781 rs2300906 chr6:88207155 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.33 -5.25 -0.31 3.05e-7 Monocyte percentage of white cells; CESC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg12311346 chr5:56204834 C5orf35 -0.7 -8.58 -0.47 8.32e-16 Initial pursuit acceleration; CESC cis rs2404602 0.647 rs7165053 chr15:76978918 A/G cg23625390 chr15:77176239 SCAPER -0.42 -5.69 -0.33 3.27e-8 Blood metabolite levels; CESC cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg00149659 chr3:10157352 C3orf10 0.98 11.92 0.59 1.59e-26 Alzheimer's disease; CESC cis rs7520050 0.966 rs10890363 chr1:46356148 C/T cg03146154 chr1:46216737 IPP 0.48 6.24 0.36 1.7e-9 Red blood cell count;Reticulocyte count; CESC cis rs892961 0.932 rs11650011 chr17:75412334 A/G cg05865280 chr17:75406074 SEPT9 0.61 12.34 0.6 5.8e-28 Airflow obstruction; CESC cis rs711245 0.545 rs848617 chr2:36811298 G/C cg01206211 chr2:36825736 FEZ2 0.34 5.92 0.34 1e-8 Height; CESC cis rs2479106 0.591 rs6478629 chr9:126442550 A/G cg16191174 chr9:126692580 DENND1A 0.39 5.3 0.31 2.38e-7 Polycystic ovary syndrome; CESC cis rs55728055 0.661 rs62237763 chr22:31947392 C/G cg01338084 chr22:32026380 PISD 1.26 8.11 0.45 1.91e-14 Age-related hearing impairment; CESC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg00802000 chr16:706648 WDR90 -0.4 -6.14 -0.35 3.03e-9 Height; CESC cis rs1878931 0.543 rs1129568 chr16:3483475 G/A cg00484396 chr16:3507460 NAT15 -0.42 -6.61 -0.38 2.07e-10 Body mass index (adult); CESC cis rs17431357 0.867 rs73225213 chr12:120946237 C/T cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.83 8.39 0.46 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg20243544 chr17:37824526 PNMT 0.48 5.99 0.35 6.77e-9 Glomerular filtration rate (creatinine); CESC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.45 0.8 7.14e-60 Prudent dietary pattern; CESC trans rs523522 0.923 rs2235217 chr12:120884328 C/T cg02849695 chr1:159869960 CCDC19 0.33 6.05 0.35 5e-9 High light scatter reticulocyte count; CESC cis rs644799 0.603 rs1255180 chr11:95472134 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.51 7.05 0.4 1.58e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs34779708 0.966 rs4934730 chr10:35415555 A/G cg04310649 chr10:35416472 CREM -0.51 -6.16 -0.35 2.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs67311347 1.000 rs28707772 chr3:40504666 G/A cg09455208 chr3:40491958 NA 0.51 8.03 0.44 3.17e-14 Renal cell carcinoma; CESC cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg20503657 chr10:835505 NA 1.09 10.01 0.52 3.32e-20 Eosinophil percentage of granulocytes; CESC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg06873352 chr17:61820015 STRADA 0.71 12.33 0.6 6.72e-28 Prudent dietary pattern; CESC trans rs629535 0.665 rs2433331 chr8:70041943 T/C cg21567404 chr3:27674614 NA 0.95 11.48 0.58 4.92e-25 Dupuytren's disease; CESC cis rs798554 0.660 rs1182175 chr7:2875026 C/T cg19717773 chr7:2847554 GNA12 0.52 8.14 0.45 1.59e-14 Height; CESC cis rs11792861 0.926 rs1333344 chr9:111776224 C/T cg05043794 chr9:111880884 C9orf5 -0.38 -6.27 -0.36 1.43e-9 Menarche (age at onset); CESC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -6.82 -0.39 6.04e-11 Bipolar disorder and schizophrenia; CESC cis rs7017914 0.967 rs7825446 chr8:71664174 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs6964587 1.000 rs733957 chr7:91707197 C/T cg17063962 chr7:91808500 NA 0.59 8.09 0.45 2.1e-14 Breast cancer; CESC cis rs939658 0.805 rs36068099 chr15:79438598 G/C cg17916960 chr15:79447300 NA -0.35 -5.96 -0.34 8.11e-9 Refractive error; CESC cis rs1144333 0.655 rs11162053 chr1:76470267 A/C cg22875332 chr1:76189707 ACADM 0.54 5.18 0.3 4.47e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg16325326 chr1:53192061 ZYG11B -0.71 -11.68 -0.58 1.05e-25 Monocyte count; CESC cis rs11169225 0.724 rs7305290 chr12:50341465 A/G cg23855989 chr12:50355821 AQP5 0.49 6.75 0.38 9.42e-11 Allergic disease (asthma, hay fever or eczema); CESC cis rs4654899 0.931 rs10753506 chr1:21141022 A/G cg05370193 chr1:21551575 ECE1 -0.37 -5.38 -0.31 1.66e-7 Superior frontal gyrus grey matter volume; CESC cis rs6754311 0.731 rs3754686 chr2:136603276 T/C cg07169764 chr2:136633963 MCM6 -0.69 -8.49 -0.46 1.51e-15 Mosquito bite size; CESC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg22920501 chr2:26401640 FAM59B -0.69 -8.44 -0.46 2.06e-15 Gut microbiome composition (summer); CESC cis rs35146811 0.807 rs6953441 chr7:99617067 G/A cg22906224 chr7:99728672 NA 0.49 5.77 0.33 2.23e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26912078 chr2:97523308 ANKRD39 -0.59 -6.33 -0.36 1.03e-9 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs11166927 0.524 rs10092101 chr8:140830697 C/T cg16909799 chr8:140841666 TRAPPC9 -0.59 -9.45 -0.5 1.83e-18 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs2197308 0.655 rs1971964 chr12:37870474 C/T cg13010199 chr12:38710504 ALG10B 0.52 6.64 0.38 1.8e-10 Morning vs. evening chronotype; CESC cis rs2635047 0.934 rs11663321 chr18:44622704 T/C cg19077165 chr18:44547161 KATNAL2 -0.5 -6.84 -0.39 5.45e-11 Educational attainment; CESC cis rs2857078 0.745 rs4793085 chr17:42320732 A/C cg09913183 chr17:42254507 C17orf65;ASB16 -0.42 -5.14 -0.3 5.21e-7 Red cell distribution width;Reticulocyte count; CESC trans rs7307889 0.793 rs73047609 chr12:5996588 G/A cg18407955 chr7:158110685 PTPRN2 -0.73 -6.22 -0.36 1.89e-9 Obesity-related traits; CESC cis rs2274273 1.000 rs15870 chr14:55619311 A/G cg04306507 chr14:55594613 LGALS3 0.28 5.23 0.31 3.42e-7 Protein biomarker; CESC cis rs6540556 0.954 rs643118 chr1:209934841 C/T cg05527609 chr1:210001259 C1orf107 -0.42 -5.28 -0.31 2.71e-7 Red blood cell count; CESC cis rs8031584 0.918 rs1425292 chr15:31285422 G/A cg08704250 chr15:31115839 NA -0.64 -8.21 -0.45 9.71e-15 Huntington's disease progression; CESC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg11859384 chr17:80120422 CCDC57 -0.39 -5.37 -0.31 1.76e-7 Life satisfaction; CESC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg01416388 chr22:39784598 NA -0.49 -6.68 -0.38 1.38e-10 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01747036 chr13:113140125 TUBGCP3 -0.65 -8.0 -0.44 3.94e-14 Gut microbiome composition (summer); CESC cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg24296786 chr1:45957014 TESK2 0.66 9.05 0.49 3.15e-17 High light scatter reticulocyte count; CESC cis rs2985684 1.000 rs3007031 chr14:50102269 G/C cg02151108 chr14:50098012 C14orf104 -0.42 -5.48 -0.32 9.97e-8 Carotid intima media thickness; CESC cis rs921968 0.607 rs529474 chr2:219463283 C/T cg02176678 chr2:219576539 TTLL4 0.42 7.12 0.4 1.01e-11 Mean corpuscular hemoglobin concentration; CESC cis rs8103278 1.000 rs35302007 chr19:46219145 G/C cg14061069 chr19:46274453 DMPK -0.38 -5.38 -0.31 1.62e-7 Coronary artery disease; CESC cis rs9811920 0.809 rs4577503 chr3:99657922 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -7.82 -0.43 1.28e-13 Axial length; CESC cis rs72634258 0.554 rs4908699 chr1:7905274 G/A cg26816564 chr1:7831052 VAMP3 0.58 5.15 0.3 5.18e-7 Inflammatory bowel disease; CESC cis rs79349575 0.749 rs8182364 chr17:47018025 A/G cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs936229 0.813 rs7085 chr15:75095483 T/C cg14664628 chr15:75095509 CSK -1.0 -15.17 -0.68 7.63e-38 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs3820928 0.874 rs2276593 chr2:227898434 A/G cg11843606 chr2:227700838 RHBDD1 0.48 6.23 0.36 1.77e-9 Pulmonary function; CESC cis rs10838687 0.867 rs2957873 chr11:47249294 G/A cg25783544 chr11:47291846 MADD -0.59 -7.45 -0.42 1.3e-12 Proinsulin levels; CESC cis rs4867766 0.871 rs113284505 chr5:173954800 A/G cg20434911 chr5:173954559 NA -0.58 -6.42 -0.37 6.37e-10 Stroke; CESC cis rs11155671 0.530 rs7768665 chr6:150208024 G/A cg09699651 chr6:150184138 LRP11 0.56 7.79 0.43 1.56e-13 Testicular germ cell tumor; CESC cis rs12220238 1.000 rs8255 chr10:75879750 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.66 6.58 0.37 2.49e-10 Soluble interleukin-2 receptor subunit alpha; CESC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg00409905 chr10:38381863 ZNF37A 0.45 5.94 0.34 8.9e-9 Extrinsic epigenetic age acceleration; CESC cis rs6665290 0.904 rs3738729 chr1:227191227 C/T cg10327440 chr1:227177885 CDC42BPA -1.22 -32.74 -0.9 3.97e-95 Myeloid white cell count; CESC cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg11752832 chr7:134001865 SLC35B4 0.52 6.74 0.38 1.01e-10 Mean platelet volume; CESC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.06 10.27 0.53 4.91e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg00149659 chr3:10157352 C3orf10 0.7 8.63 0.47 5.68e-16 Alzheimer's disease; CESC cis rs7914558 1.000 rs4917380 chr10:104775335 C/G cg04362960 chr10:104952993 NT5C2 0.43 5.77 0.33 2.19e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs16867321 0.627 rs7571765 chr2:181590328 G/A cg23363182 chr2:181467187 NA 0.44 6.57 0.37 2.71e-10 Obesity; CESC cis rs11785400 1.000 rs10108059 chr8:143750028 G/T cg10596483 chr8:143751796 JRK -0.44 -5.6 -0.33 5.29e-8 Schizophrenia; CESC trans rs72991 0.793 rs10790443 chr11:121234131 G/T cg26394191 chr3:123459423 MYLK 0.28 6.62 0.38 1.94e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs11583043 0.918 rs56402739 chr1:101397133 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 5.17 0.3 4.71e-7 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs9815354 0.680 rs75308766 chr3:42031894 G/A cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs9902453 0.967 rs1906450 chr17:28515744 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 7.68 0.43 3.18e-13 Coffee consumption (cups per day); CESC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.49 7.18 0.4 6.94e-12 Electroencephalogram traits; CESC cis rs78707713 0.841 rs7475662 chr10:71210744 G/C cg12610070 chr10:71211762 TSPAN15 -0.36 -6.48 -0.37 4.36e-10 Venous thromboembolism; CESC cis rs5750830 0.620 rs1007337 chr22:39781585 C/T cg24399712 chr22:39784796 NA -0.77 -11.15 -0.57 6.39e-24 Intelligence (multi-trait analysis); CESC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg12311346 chr5:56204834 C5orf35 -0.74 -8.75 -0.47 2.61e-16 Initial pursuit acceleration; CESC cis rs6502050 0.799 rs58538819 chr17:80107153 G/C cg01763666 chr17:80159506 CCDC57 -0.38 -5.17 -0.3 4.61e-7 Life satisfaction; CESC cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg24110177 chr3:50126178 RBM5 -0.58 -8.07 -0.44 2.48e-14 Body mass index; CESC trans rs2727020 0.658 rs10839269 chr11:49385596 A/G cg03929089 chr4:120376271 NA -0.81 -12.68 -0.61 4.19e-29 Coronary artery disease; CESC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg07414643 chr4:187882934 NA 0.55 7.97 0.44 4.6e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs9487051 0.676 rs6910119 chr6:109599263 A/G cg01475377 chr6:109611718 NA -0.43 -6.82 -0.39 6.19e-11 Reticulocyte fraction of red cells; CESC cis rs6964587 0.967 rs10279943 chr7:91587477 G/C cg17063962 chr7:91808500 NA 0.58 7.92 0.44 6.66e-14 Breast cancer; CESC cis rs11098499 0.739 rs9996382 chr4:120151012 C/T cg09307838 chr4:120376055 NA 0.63 8.03 0.44 3.16e-14 Corneal astigmatism; CESC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.46 5.93 0.34 9.24e-9 Tonsillectomy; CESC cis rs7927592 0.956 rs2510384 chr11:68391837 C/A cg20283391 chr11:68216788 NA -0.47 -5.48 -0.32 1e-7 Total body bone mineral density; CESC cis rs7264396 0.563 rs2425081 chr20:34299733 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.64 -0.55 3.06e-22 Total cholesterol levels; CESC cis rs1475911 0.708 rs56109792 chr21:43520060 A/G cg14562523 chr21:43528734 C21orf128;UMODL1 -0.46 -7.06 -0.4 1.46e-11 IgG glycosylation; CESC cis rs11252926 0.770 rs4880736 chr10:680133 C/G cg08603382 chr10:743973 NA 0.41 5.68 0.33 3.55e-8 Psychosis in Alzheimer's disease; CESC cis rs1348850 0.914 rs4341974 chr2:178324879 A/C cg22681709 chr2:178499509 PDE11A -0.39 -5.69 -0.33 3.29e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7208859 0.623 rs9891166 chr17:29111902 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg24829409 chr8:58192753 C8orf71 -0.76 -10.0 -0.52 3.53e-20 Developmental language disorder (linguistic errors); CESC cis rs1348850 0.540 rs10172355 chr2:178443225 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 5.11 0.3 6.11e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs962856 0.604 rs2035566 chr2:67616273 G/C cg09028215 chr2:67624308 ETAA1 -0.44 -5.26 -0.31 3.04e-7 Pancreatic cancer; CESC cis rs1008375 0.931 rs10008337 chr4:17593849 G/C cg27347728 chr4:17578864 LAP3 0.44 5.24 0.31 3.33e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14472251 chr14:55493991 SOCS4;WDHD1 0.58 6.24 0.36 1.73e-9 Gut microbiome composition (summer); CESC cis rs2274273 0.840 rs6573014 chr14:55735892 C/T cg04306507 chr14:55594613 LGALS3 -0.28 -5.46 -0.32 1.1e-7 Protein biomarker; CESC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg19500275 chr17:80737654 TBCD 0.49 5.6 0.33 5.23e-8 Glycated hemoglobin levels; CESC cis rs72781680 1.000 rs17762782 chr2:24126493 A/G cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs763121 0.853 rs10135 chr22:39082174 C/T cg06022373 chr22:39101656 GTPBP1 -0.93 -17.03 -0.72 1.95e-44 Menopause (age at onset); CESC cis rs2742234 0.915 rs2742233 chr10:43610558 C/T cg07801480 chr10:43725741 RASGEF1A 0.39 5.39 0.31 1.56e-7 Hirschsprung disease; CESC cis rs17826219 0.706 rs57698184 chr17:29064918 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.31 0.36 1.17e-9 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03823108 chr20:1099106 PSMF1 -0.5 -6.89 -0.39 3.94e-11 Fibrinogen levels; CESC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg07701084 chr6:150067640 NUP43 0.45 6.39 0.37 7.37e-10 Lung cancer; CESC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg06873352 chr17:61820015 STRADA 0.74 13.19 0.63 7.17e-31 Prudent dietary pattern; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03092603 chr22:38712210 CSNK1E 0.44 6.35 0.36 9.3e-10 Gut microbiota (bacterial taxa); CESC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg11764359 chr7:65958608 NA -0.79 -9.51 -0.5 1.18e-18 Aortic root size; CESC cis rs9325144 0.602 rs10785590 chr12:38694145 C/T cg26384229 chr12:38710491 ALG10B 0.58 8.47 0.46 1.67e-15 Morning vs. evening chronotype; CESC cis rs1832871 0.683 rs62437360 chr6:158720162 G/A cg07165851 chr6:158734300 TULP4 0.6 6.59 0.38 2.33e-10 Height; CESC cis rs1152591 0.562 rs1262242 chr14:64653869 C/T cg21174375 chr14:64681225 SYNE2 0.56 8.07 0.44 2.49e-14 Atrial fibrillation; CESC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.63 0.38 1.89e-10 Prudent dietary pattern; CESC cis rs6032067 0.641 rs35882692 chr20:43763968 T/C cg10761708 chr20:43804764 PI3 0.54 5.85 0.34 1.45e-8 Blood protein levels; CESC cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.51 6.39 0.37 7.37e-10 Tuberculosis; CESC cis rs11792861 0.926 rs72607169 chr9:111832471 A/T cg13535736 chr9:111863775 C9orf5 -0.51 -6.84 -0.39 5.58e-11 Menarche (age at onset); CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 6.16 0.35 2.7e-9 Electroencephalogram traits; CESC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg23048001 chr7:2026167 MAD1L1 0.45 5.88 0.34 1.24e-8 Bipolar disorder and schizophrenia; CESC cis rs6815814 0.851 rs17582893 chr4:38886420 G/A cg02016764 chr4:38805732 TLR1 -0.56 -6.33 -0.36 1.07e-9 Breast cancer; CESC cis rs7714584 0.793 rs11958146 chr5:150254158 A/G cg22134413 chr5:150180641 NA 0.51 5.92 0.34 9.88e-9 Crohn's disease; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg23667933 chr9:71650719 FXN -0.58 -6.42 -0.37 6.29e-10 Subjective well-being; CESC trans rs7618501 0.966 rs7372966 chr3:49788969 T/C cg21659725 chr3:3221576 CRBN -0.83 -13.42 -0.64 1.08e-31 Intelligence (multi-trait analysis); CESC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.64 -8.23 -0.45 8.51e-15 Tonsillectomy; CESC cis rs921968 0.565 rs7599945 chr2:219641528 G/T cg02176678 chr2:219576539 TTLL4 -0.43 -7.67 -0.43 3.39e-13 Mean corpuscular hemoglobin concentration; CESC trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.39 -0.46 2.92e-15 Intelligence (multi-trait analysis); CESC cis rs2011503 1.000 rs80007081 chr19:19626734 A/G cg11584989 chr19:19387371 SF4 0.61 7.06 0.4 1.45e-11 Bipolar disorder; CESC cis rs34172651 0.617 rs9922436 chr16:24704490 C/G cg06028605 chr16:24865363 SLC5A11 0.44 6.45 0.37 5.41e-10 Intelligence (multi-trait analysis); CESC cis rs6912958 0.754 rs2268994 chr6:88185386 A/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -5.84 -0.34 1.52e-8 Monocyte percentage of white cells; CESC cis rs1775715 0.737 rs2799031 chr10:32173168 C/T cg18675610 chr10:32216311 ARHGAP12 0.35 5.38 0.31 1.65e-7 Bipolar disorder with mood-incongruent psychosis; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12243255 chr3:39194549 CSRNP1 0.47 6.24 0.36 1.68e-9 Systemic lupus erythematosus; CESC cis rs950027 0.620 rs1145089 chr15:45652054 G/C cg21132104 chr15:45694354 SPATA5L1 0.66 8.52 0.46 1.22e-15 Response to fenofibrate (adiponectin levels); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10459717 chr5:6633577 NSUN2;SRD5A1 -0.48 -6.3 -0.36 1.22e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2072732 0.861 rs12042403 chr1:2950872 T/C cg03976712 chr1:2946727 NA 0.33 5.45 0.32 1.17e-7 Plateletcrit; CESC cis rs3008870 1.000 rs1118393 chr1:67366668 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.02 14.09 0.65 4.84e-34 Lymphocyte percentage of white cells; CESC cis rs7017914 0.967 rs34558600 chr8:71586152 G/A cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.09 -0.3 6.93e-7 Bone mineral density; CESC cis rs752010 0.715 rs4660551 chr1:42099979 T/C cg06885757 chr1:42089581 HIVEP3 0.7 10.94 0.56 3.02e-23 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00504134 chr3:152552530 P2RY1 0.52 6.14 0.35 2.93e-9 Gut microbiome composition (summer); CESC cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg06636001 chr8:8085503 FLJ10661 0.51 6.35 0.36 9.5e-10 Mood instability; CESC trans rs2755237 0.656 rs2721051 chr13:41110884 C/T cg16029875 chr1:204320179 PLEKHA6 -0.66 -6.04 -0.35 5.11e-9 Central corneal thickness; CESC cis rs7937682 0.632 rs4441050 chr11:111772506 C/T cg22437258 chr11:111473054 SIK2 -0.5 -5.5 -0.32 8.78e-8 Primary sclerosing cholangitis; CESC cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg05340658 chr4:99064831 C4orf37 0.69 9.2 0.49 1.08e-17 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg05340658 chr4:99064831 C4orf37 0.79 12.33 0.6 6.78e-28 Colonoscopy-negative controls vs population controls; CESC cis rs16854884 0.586 rs7639366 chr3:143752034 T/G cg01302019 chr3:143689584 C3orf58 -0.32 -5.07 -0.3 7.32e-7 Economic and political preferences (feminism/equality); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg17213616 chr1:5933044 NPHP4 0.45 6.09 0.35 3.86e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs13064411 0.696 rs9814395 chr3:113188885 C/T cg18753928 chr3:113234510 CCDC52 -0.46 -5.45 -0.32 1.13e-7 Response to simvastatin treatment (PCSK9 protein level change); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06936779 chr1:151171405 PIP5K1A 0.58 6.57 0.37 2.7e-10 Gut microbiome composition (summer); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19990977 chr19:10654446 ATG4D -0.48 -6.02 -0.35 5.86e-9 Asthma; CESC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg06074448 chr4:187884817 NA -0.38 -5.31 -0.31 2.3e-7 Lobe attachment (rater-scored or self-reported); CESC trans rs1814175 0.645 rs28447324 chr11:50046629 C/A cg11707556 chr5:10655725 ANKRD33B -0.42 -6.1 -0.35 3.76e-9 Height; CESC cis rs6750795 0.602 rs1667317 chr2:232412036 T/C cg19187155 chr2:232395269 NMUR1 0.59 7.53 0.42 7.74e-13 Height; CESC cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.73 10.79 0.55 9.56e-23 Hip circumference adjusted for BMI; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg08912860 chr12:132863782 GALNT9 0.29 6.05 0.35 4.81e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg24044651 chr1:24105262 C1orf128 0.46 6.06 0.35 4.69e-9 Systemic lupus erythematosus; CESC cis rs17253792 0.545 rs71412688 chr14:56021539 A/G cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs7953249 0.594 rs11065384 chr12:121423285 T/C cg25281562 chr12:121454272 C12orf43 -0.55 -6.95 -0.39 2.81e-11 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CESC cis rs367943 0.712 rs10053654 chr5:112724314 G/C cg12552261 chr5:112820674 MCC 0.38 5.15 0.3 5.04e-7 Type 2 diabetes; CESC cis rs8060686 0.516 rs7193701 chr16:68185160 A/G cg26727032 chr16:67993705 SLC12A4 0.48 6.85 0.39 5.14e-11 HDL cholesterol;Metabolic syndrome; CESC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg16680214 chr1:154839983 KCNN3 -0.44 -6.78 -0.38 7.71e-11 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19898828 chr8:110346621 NUDCD1;ENY2 0.51 6.17 0.35 2.56e-9 Gut microbiome composition (summer); CESC cis rs6087990 0.735 rs2424914 chr20:31374520 A/G cg13636640 chr20:31349939 DNMT3B 0.81 13.19 0.63 6.87e-31 Ulcerative colitis; CESC cis rs3857067 0.934 rs899132 chr4:95040022 A/C cg11021082 chr4:95130006 SMARCAD1 0.5 7.61 0.42 4.95e-13 QT interval; CESC cis rs763014 0.833 rs3743904 chr16:632767 A/G cg09263875 chr16:632152 PIGQ 0.67 11.21 0.57 3.99e-24 Height; CESC cis rs2243480 1.000 rs34193460 chr7:65393110 A/G cg25894440 chr7:65020034 NA -0.64 -5.31 -0.31 2.33e-7 Diabetic kidney disease; CESC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg22903471 chr2:27725779 GCKR -0.51 -7.17 -0.4 7.47e-12 Total body bone mineral density; CESC cis rs5769765 0.908 rs138891 chr22:50227741 G/A cg02269571 chr22:50332266 NA -0.46 -5.95 -0.34 8.65e-9 Schizophrenia; CESC cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg00406319 chr10:126851303 NA -0.38 -6.11 -0.35 3.46e-9 Menarche (age at onset); CESC cis rs9467711 0.606 rs9379899 chr6:26603015 T/A cg21479132 chr6:26055353 NA 0.65 5.69 0.33 3.29e-8 Autism spectrum disorder or schizophrenia; CESC cis rs3892630 0.588 rs28787932 chr19:33226229 T/C cg22980127 chr19:33182716 NUDT19 1.14 14.45 0.66 2.72e-35 Red blood cell traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00840257 chr16:8963031 CARHSP1 0.64 7.49 0.42 1.03e-12 Gut microbiome composition (summer); CESC cis rs897984 0.683 rs12447534 chr16:30804257 C/T cg00531865 chr16:30841666 NA 0.55 8.01 0.44 3.66e-14 Dementia with Lewy bodies; CESC cis rs763121 0.853 rs1062687 chr22:39134715 T/C cg06022373 chr22:39101656 GTPBP1 0.92 17.03 0.72 1.87e-44 Menopause (age at onset); CESC cis rs561341 0.609 rs739800 chr17:30190083 T/A cg13647721 chr17:30228624 UTP6 -0.74 -8.56 -0.47 9.61e-16 Hip circumference adjusted for BMI; CESC cis rs9527 0.637 rs12219247 chr10:104613361 A/G cg15744005 chr10:104629667 AS3MT -0.37 -5.66 -0.33 3.95e-8 Arsenic metabolism; CESC cis rs10883723 0.641 rs80146619 chr10:104405850 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.62 6.03 0.35 5.39e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs2485892 0.581 rs2484032 chr1:210317225 G/A cg23283495 chr1:209979779 IRF6 0.44 5.54 0.32 7.24e-8 Manic episodes in bipolar disorder; CESC cis rs454510 0.816 rs838987 chr1:120176127 A/G cg11530693 chr1:120165357 ZNF697 0.43 5.48 0.32 9.71e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs193541 0.632 rs62377425 chr5:122332625 C/G cg19412675 chr5:122181750 SNX24 -0.46 -5.38 -0.31 1.67e-7 Glucose homeostasis traits; CESC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg04518342 chr5:131593106 PDLIM4 -0.37 -5.13 -0.3 5.55e-7 Acylcarnitine levels; CESC cis rs35110281 0.667 rs4818859 chr21:45117120 G/A cg01579765 chr21:45077557 HSF2BP -0.51 -8.35 -0.46 3.74e-15 Mean corpuscular volume; CESC cis rs796364 0.806 rs1605900 chr2:200870197 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.83 7.5 0.42 9.65e-13 Schizophrenia; CESC cis rs2249694 0.960 rs4556495 chr10:135422209 C/T cg19469447 chr10:135341870 CYP2E1 0.36 5.17 0.3 4.65e-7 Obesity-related traits; CESC cis rs910316 0.737 rs175049 chr14:75481368 C/T cg08847533 chr14:75593920 NEK9 -0.89 -15.25 -0.68 4.09e-38 Height; CESC cis rs9303401 0.614 rs34843288 chr17:57103140 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.96 11.01 0.56 1.87e-23 Cognitive test performance; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24688926 chr19:6737877 GPR108 -0.49 -6.48 -0.37 4.41e-10 Asthma; CESC cis rs2479724 0.818 rs9357369 chr6:41818202 A/C cg08135965 chr6:41755394 TOMM6 0.4 5.57 0.32 6.33e-8 Menarche (age at onset); CESC cis rs7937682 0.855 rs7109592 chr11:111533105 C/A cg09085632 chr11:111637200 PPP2R1B -0.99 -16.33 -0.71 5.97e-42 Primary sclerosing cholangitis; CESC cis rs910316 1.000 rs175436 chr14:75608683 C/G cg08847533 chr14:75593920 NEK9 -0.96 -18.37 -0.75 3.6e-49 Height; CESC cis rs17376456 0.877 rs10476601 chr5:93402522 G/A cg25358565 chr5:93447407 FAM172A 1.13 10.9 0.56 4.33e-23 Diabetic retinopathy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G ch.12.2922115F chr12:133248407 POLE 0.52 6.83 0.39 5.66e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg04511125 chr2:88470314 THNSL2 -0.52 -7.48 -0.42 1.1e-12 Response to metformin (IC50); CESC cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg24296786 chr1:45957014 TESK2 0.63 8.37 0.46 3.36e-15 High light scatter reticulocyte count; CESC trans rs17685 0.753 rs1104878 chr7:75685593 G/T cg19862616 chr7:65841803 NCRNA00174 0.83 12.38 0.61 4.45e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs4835473 0.932 rs35017645 chr4:144681349 A/G cg25736465 chr4:144833511 NA -0.43 -6.52 -0.37 3.62e-10 Immature fraction of reticulocytes; CESC cis rs763121 0.886 rs1013339 chr22:38974680 C/T cg21395723 chr22:39101663 GTPBP1 0.43 5.6 0.33 5.44e-8 Menopause (age at onset); CESC cis rs11871801 0.517 rs6963 chr17:40731597 A/T cg21433558 chr17:40837037 CNTNAP1 -0.48 -5.8 -0.34 1.84e-8 Crohn's disease; CESC cis rs9868809 0.881 rs3806694 chr3:48672334 G/C cg07636037 chr3:49044803 WDR6 -0.63 -5.15 -0.3 5.14e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs2228479 0.867 rs62052168 chr16:89947203 G/A cg04013166 chr16:89971882 TCF25 0.76 6.47 0.37 4.59e-10 Skin colour saturation; CESC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.53 -5.93 -0.34 9.61e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6456156 0.586 rs9457266 chr6:167482555 T/C cg07741184 chr6:167504864 NA 0.37 6.36 0.36 8.83e-10 Primary biliary cholangitis; CESC cis rs617219 0.889 rs1622238 chr5:78437340 A/G cg22188827 chr5:78429774 NA -0.43 -5.1 -0.3 6.62e-7 Betaine levels in individuals undergoing cardiac evaluation; CESC cis rs41271473 0.526 rs72765760 chr1:228743222 G/A cg16512390 chr1:228756714 NA 0.55 5.66 0.33 3.84e-8 Chronic lymphocytic leukemia; CESC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.69 -0.33 3.28e-8 Prostate cancer (SNP x SNP interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07318073 chr4:74904359 CXCL3 0.6 6.39 0.37 7.28e-10 Gut microbiome composition (summer); CESC cis rs372883 0.648 rs1153288 chr21:30686091 A/G cg08807101 chr21:30365312 RNF160 0.45 5.31 0.31 2.32e-7 Pancreatic cancer; CESC cis rs12765878 1.000 rs11191846 chr10:105649813 A/G cg11005552 chr10:105648138 OBFC1 0.34 5.05 0.3 8.35e-7 Coronary artery disease; CESC cis rs4971059 0.654 rs4971076 chr1:155124772 C/A cg22049894 chr1:155113146 DPM3 0.47 6.06 0.35 4.62e-9 Breast cancer; CESC cis rs708547 0.647 rs781668 chr4:57825140 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.6 -8.07 -0.44 2.49e-14 Response to bleomycin (chromatid breaks); CESC cis rs7772486 0.902 rs2748500 chr6:146314852 C/A cg05347473 chr6:146136440 FBXO30 0.49 6.6 0.38 2.28e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg18099408 chr3:52552593 STAB1 -0.36 -6.09 -0.35 4.06e-9 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00264380 chr18:48405387 ME2 0.58 6.61 0.38 2.07e-10 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg18402987 chr7:1209562 NA 0.76 7.56 0.42 6.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs67257959 0.586 rs8105085 chr19:17159962 G/A cg16202187 chr19:17186497 HAUS8;MYO9B 0.52 6.78 0.38 7.69e-11 Selective IgA deficiency; CESC cis rs2732480 0.577 rs2450994 chr12:48721832 G/A cg24011408 chr12:48396354 COL2A1 0.4 5.76 0.33 2.31e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg03609598 chr5:56110824 MAP3K1 -0.53 -5.62 -0.33 4.78e-8 Initial pursuit acceleration; CESC cis rs116095464 0.558 rs59113266 chr5:279965 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.77e-15 Breast cancer; CESC cis rs8040855 0.627 rs4980356 chr15:85608132 G/A cg08123816 chr15:85640762 PDE8A -0.41 -6.07 -0.35 4.31e-9 Bulimia nervosa; CESC cis rs854765 0.547 rs2955356 chr17:17964717 G/A cg04398451 chr17:18023971 MYO15A 0.72 10.46 0.54 1.15e-21 Total body bone mineral density; CESC cis rs34734847 1.000 rs56179458 chr12:121157535 G/A cg21892295 chr12:121157589 UNC119B -0.42 -6.65 -0.38 1.66e-10 Mean corpuscular volume; CESC cis rs1580019 0.522 rs10951340 chr7:32562408 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.51 0.37 3.72e-10 Cognitive ability; CESC cis rs7520050 0.966 rs4076006 chr1:46438076 C/T cg03146154 chr1:46216737 IPP -0.47 -6.03 -0.35 5.46e-9 Red blood cell count;Reticulocyte count; CESC cis rs34779708 0.966 rs17499247 chr10:35426755 A/G cg03585969 chr10:35415529 CREM 0.76 10.3 0.53 3.72e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs977987 0.806 rs1895490 chr16:75392806 G/A cg03315344 chr16:75512273 CHST6 0.39 5.63 0.33 4.61e-8 Dupuytren's disease; CESC trans rs4927850 0.881 rs7624638 chr3:195748729 C/T cg16724585 chr3:197361211 NA -0.56 -7.07 -0.4 1.39e-11 Pancreatic cancer; CESC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg18110333 chr6:292329 DUSP22 -0.75 -10.06 -0.53 2.21e-20 Menopause (age at onset); CESC cis rs11760633 0.672 rs7811019 chr7:1843541 C/G cg23422044 chr7:1970798 MAD1L1 -0.48 -5.54 -0.32 7.14e-8 Coronary artery disease; CESC cis rs10876993 0.890 rs1678516 chr12:58047458 G/A cg18357645 chr12:58087776 OS9 0.59 9.02 0.48 3.88e-17 Celiac disease or Rheumatoid arthritis; CESC cis rs116095464 0.558 rs56081398 chr5:247318 C/T cg22496380 chr5:211416 CCDC127 -0.98 -10.28 -0.53 4.47e-21 Breast cancer; CESC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg06456125 chr7:65229604 NA 0.39 5.07 0.3 7.38e-7 Aortic root size; CESC cis rs9796 0.870 rs1001341 chr15:41261491 T/A cg18705301 chr15:41695430 NDUFAF1 0.43 6.28 0.36 1.41e-9 Menopause (age at onset); CESC cis rs3845702 1.000 rs3845697 chr2:180798553 C/T cg01881094 chr2:180872142 CWC22 0.65 6.73 0.38 1.07e-10 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26304119 chr11:67265369 PITPNM1 -0.57 -7.11 -0.4 1.08e-11 Gut microbiome composition (summer); CESC cis rs11048434 0.649 rs11613650 chr12:9060396 T/C cg04155231 chr12:9217510 LOC144571 0.33 5.36 0.31 1.77e-7 Sjögren's syndrome; CESC cis rs2370759 1.000 rs79487858 chr10:32616405 T/C cg01819863 chr10:32635814 EPC1 1.16 12.42 0.61 3.2e-28 Sexual dysfunction (female); CESC cis rs35306767 0.909 rs12264390 chr10:959111 T/C cg26597838 chr10:835615 NA 0.77 9.03 0.49 3.62e-17 Eosinophil percentage of granulocytes; CESC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.77 -9.88 -0.52 8.65e-20 Alzheimer's disease; CESC cis rs4523957 0.890 rs9908888 chr17:2102453 G/C cg16513277 chr17:2031491 SMG6 -0.67 -9.26 -0.49 7.04e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2204008 0.774 rs3910796 chr12:38230660 G/T cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Bladder cancer; CESC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg01238044 chr22:24384105 GSTT1 -0.5 -6.21 -0.36 2.08e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3809863 0.602 rs2317677 chr17:45393407 G/A cg25173405 chr17:45401733 C17orf57 -0.54 -6.98 -0.39 2.34e-11 Glaucoma (primary open-angle); CESC cis rs1568889 1.000 rs7951681 chr11:28273894 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 10.99 0.56 2.09e-23 Bipolar disorder; CESC trans rs1945213 0.694 rs67394518 chr11:55855303 G/A cg03929089 chr4:120376271 NA 0.73 6.63 0.38 1.85e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs67311347 1.000 rs12633431 chr3:40505740 C/T cg24209194 chr3:40518798 ZNF619 -0.54 -7.1 -0.4 1.13e-11 Renal cell carcinoma; CESC cis rs7267979 1.000 rs6050561 chr20:25334855 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.85e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs6456156 0.792 rs9366089 chr6:167512896 A/G cg23791538 chr6:167370224 RNASET2 -0.41 -5.3 -0.31 2.45e-7 Primary biliary cholangitis; CESC cis rs1185460 0.967 rs1784302 chr11:118940957 C/G cg23280166 chr11:118938394 VPS11 0.57 7.85 0.43 1.04e-13 Coronary artery disease; CESC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.55 -0.37 2.91e-10 Bipolar disorder; CESC trans rs7937682 0.889 rs558736 chr11:111500760 C/G cg18187862 chr3:45730750 SACM1L 0.52 6.55 0.37 2.95e-10 Primary sclerosing cholangitis; CESC cis rs8092503 1.000 rs12960467 chr18:52492951 C/G cg12377874 chr18:52495404 RAB27B 0.38 5.95 0.34 8.67e-9 Childhood body mass index; CESC cis rs2235649 0.592 rs2429186 chr16:1969939 C/T cg03715980 chr16:1756201 MAPK8IP3 0.45 5.11 0.3 6.31e-7 Blood metabolite levels; CESC cis rs5995756 0.697 rs713865 chr22:39997630 C/T cg03390717 chr22:39966585 CACNA1I -0.32 -5.41 -0.32 1.38e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg03806693 chr22:41940476 POLR3H -1.12 -13.95 -0.65 1.55e-33 Vitiligo; CESC cis rs7089973 0.604 rs2181563 chr10:116604344 T/C cg25233709 chr10:116636983 FAM160B1 0.38 6.44 0.37 5.46e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs11792861 0.816 rs7027263 chr9:111699569 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 6.59 0.38 2.3e-10 Menarche (age at onset); CESC cis rs854765 0.547 rs2955377 chr17:17932818 G/A cg09796270 chr17:17721594 SREBF1 0.37 5.08 0.3 7.17e-7 Total body bone mineral density; CESC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg04369109 chr6:150039330 LATS1 -0.42 -5.95 -0.34 8.52e-9 Lung cancer; CESC trans rs17764205 0.777 rs17696630 chr19:3261995 A/G cg13921652 chr1:144931966 PDE4DIP -0.75 -6.15 -0.35 2.81e-9 Bipolar disorder and schizophrenia; CESC cis rs12137294 0.866 rs1172151 chr1:205221659 A/C cg21643547 chr1:205240462 TMCC2 -0.35 -5.71 -0.33 3.04e-8 Red cell distribution width; CESC cis rs9560113 0.509 rs28608633 chr13:112206880 G/A cg10483660 chr13:112241077 NA 0.42 7.14 0.4 9e-12 Menarche (age at onset); CESC cis rs9611565 0.921 rs4822021 chr22:41726053 G/A cg06634786 chr22:41940651 POLR3H -0.63 -6.75 -0.38 9.25e-11 Vitiligo; CESC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2708240 1.000 rs2538979 chr7:147582719 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 0.32 5.25 0.31 3.12e-7 QT interval (drug interaction); CESC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg18876405 chr7:65276391 NA 0.49 6.42 0.37 6.43e-10 Aortic root size; CESC cis rs3924048 0.559 rs6541039 chr1:12626261 T/C cg00291366 chr1:12616550 NA 0.36 6.26 0.36 1.5e-9 Optic cup area; CESC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.7 -8.01 -0.44 3.69e-14 Gut microbiome composition (summer); CESC cis rs2180341 0.711 rs4371861 chr6:127568447 G/T cg27446573 chr6:127587934 RNF146 0.67 9.9 0.52 7.15e-20 Breast cancer; CESC cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.72 10.87 0.56 5.43e-23 Hip circumference adjusted for BMI; CESC cis rs8044868 0.530 rs2287999 chr16:72059149 A/G cg16558253 chr16:72132732 DHX38 -0.37 -5.67 -0.33 3.8e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC trans rs9467711 0.659 rs3823158 chr6:26463271 T/A cg06606381 chr12:133084897 FBRSL1 -0.95 -7.31 -0.41 3.06e-12 Autism spectrum disorder or schizophrenia; CESC cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg12365402 chr11:9010492 NRIP3 -0.31 -5.16 -0.3 4.76e-7 Hemoglobin concentration; CESC cis rs6582630 0.502 rs7312212 chr12:38274760 T/G cg26384229 chr12:38710491 ALG10B 0.65 9.03 0.49 3.55e-17 Drug-induced liver injury (flucloxacillin); CESC cis rs9875589 0.509 rs2129888 chr3:14013826 A/T cg19554555 chr3:13937349 NA -0.42 -5.35 -0.31 1.86e-7 Ovarian reserve; CESC cis rs4692589 0.606 rs12645495 chr4:170933909 T/C cg19918862 chr4:170955249 NA 0.41 5.32 0.31 2.22e-7 Anxiety disorder; CESC cis rs854765 0.552 rs6502624 chr17:17847936 G/A cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC cis rs72772090 0.539 rs116360011 chr5:96117797 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.18 -0.3 4.41e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4072980 0.545 rs16824518 chr1:38415315 A/C cg18451016 chr1:38461880 NA -0.37 -5.04 -0.3 8.5e-7 Coronary artery disease; CESC cis rs12618769 0.543 rs4851132 chr2:99042782 T/C cg10123293 chr2:99228465 UNC50 0.4 5.34 0.31 1.97e-7 Bipolar disorder; CESC cis rs561341 1.000 rs8070262 chr17:30262467 A/G cg19193384 chr17:30244184 NA -0.48 -5.52 -0.32 8.2e-8 Hip circumference adjusted for BMI; CESC cis rs6565180 0.507 rs4471699 chr16:30320307 G/T cg17640201 chr16:30407289 ZNF48 -0.67 -9.33 -0.5 4.28e-18 Tonsillectomy; CESC cis rs2243480 0.803 rs36004293 chr7:65416512 T/C cg13147721 chr7:65941812 NA -0.86 -8.49 -0.46 1.47e-15 Diabetic kidney disease; CESC cis rs698813 0.674 rs713447 chr2:44505185 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.48 5.18 0.3 4.32e-7 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CESC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg11247378 chr22:39784982 NA -0.62 -9.06 -0.49 2.88e-17 Intelligence (multi-trait analysis); CESC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg10691866 chr7:65817282 TPST1 0.31 5.24 0.31 3.34e-7 Aortic root size; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27453922 chr7:148922355 ZNF282 0.5 6.45 0.37 5.22e-10 Fibrinogen levels; CESC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg07092213 chr7:1199455 ZFAND2A -0.43 -5.57 -0.32 6.36e-8 Longevity;Endometriosis; CESC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 13.15 0.63 1e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7615952 0.688 rs7624806 chr3:125599074 G/A cg07211511 chr3:129823064 LOC729375 -1.03 -13.07 -0.63 1.76e-30 Blood pressure (smoking interaction); CESC cis rs6695640 0.820 rs6678862 chr1:17744852 G/A cg01904812 chr1:17746340 RCC2 0.36 5.29 0.31 2.51e-7 Mean platelet volume; CESC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg12963246 chr6:28129442 ZNF389 0.41 6.0 0.35 6.29e-9 Cardiac Troponin-T levels; CESC cis rs7809950 0.817 rs58052742 chr7:107210003 A/G cg23024343 chr7:107201750 COG5 0.57 7.24 0.41 4.92e-12 Coronary artery disease; CESC cis rs116095464 0.558 rs6875291 chr5:264192 T/C cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.51e-10 Breast cancer; CESC cis rs6690583 0.623 rs75918067 chr1:85453413 T/C cg22153463 chr1:85462885 MCOLN2 0.71 7.12 0.4 1.01e-11 Serum sulfate level; CESC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg18016565 chr1:150552671 MCL1 0.34 5.07 0.3 7.52e-7 Melanoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01394034 chr12:98909208 TMPO;LOC100128191 0.61 6.67 0.38 1.51e-10 Gut microbiome composition (summer); CESC cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg10523679 chr1:76189770 ACADM 0.68 6.77 0.38 8.41e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg17340268 chr14:105411764 AHNAK2 -0.5 -6.75 -0.38 9.45e-11 Rheumatoid arthritis; CESC cis rs6582630 0.519 rs11520262 chr12:38333051 A/G cg13010199 chr12:38710504 ALG10B 0.48 6.11 0.35 3.53e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs35306767 0.903 rs12764024 chr10:922861 A/G cg10556349 chr10:835070 NA 0.55 5.54 0.32 7.41e-8 Eosinophil percentage of granulocytes; CESC cis rs752010 0.905 rs4525030 chr1:42091307 G/C cg06885757 chr1:42089581 HIVEP3 0.46 7.42 0.41 1.64e-12 Lupus nephritis in systemic lupus erythematosus; CESC cis rs8016982 0.609 rs8009519 chr14:81702503 C/G cg01989461 chr14:81687754 GTF2A1 0.75 11.77 0.59 5.41e-26 Schizophrenia; CESC cis rs7923609 1.000 rs10822163 chr10:65124098 C/G cg01631684 chr10:65280961 REEP3 -0.41 -5.15 -0.3 5.05e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg22702420 chr1:213031749 FLVCR1;LQK1 -0.55 -6.5 -0.37 3.94e-10 Ulcerative colitis; CESC cis rs7085104 0.514 rs284855 chr10:104574422 A/G cg04362960 chr10:104952993 NT5C2 -0.47 -6.37 -0.36 8.3e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs12681366 0.734 rs16916788 chr8:95399618 C/T cg13257157 chr8:95487014 RAD54B 0.38 5.14 0.3 5.22e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs17685 0.712 rs6464994 chr7:75784668 C/T cg19862616 chr7:65841803 NCRNA00174 0.8 11.44 0.57 6.89e-25 Coffee consumption;Coffee consumption (cups per day); CESC cis rs7542091 0.669 rs7540534 chr1:210044824 A/T cg25204440 chr1:209979598 IRF6 0.37 5.1 0.3 6.55e-7 Monobrow; CESC cis rs4253772 0.591 rs11704614 chr22:46691936 A/G cg00784671 chr22:46762841 CELSR1 -0.58 -5.61 -0.33 4.99e-8 LDL cholesterol;Cholesterol, total; CESC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg17414380 chr19:19431394 KIAA0892;SF4 0.49 6.0 0.35 6.47e-9 Tonsillectomy; CESC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 20.7 0.79 2.79e-57 Prudent dietary pattern; CESC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg08736216 chr1:53307985 ZYG11A 0.41 6.86 0.39 4.94e-11 Monocyte count; CESC trans rs7726839 0.574 rs12517345 chr5:628294 G/A cg25482853 chr8:67687455 SGK3 1.01 9.87 0.52 8.86e-20 Obesity-related traits; CESC cis rs10208940 0.920 rs72903979 chr2:68813938 C/T cg12452813 chr2:68675892 NA 0.53 5.29 0.31 2.54e-7 Urate levels in lean individuals; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25560965 chr12:12510064 LOH12CR1;LOH12CR2 -0.44 -6.21 -0.36 2.09e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg26335602 chr6:28129616 ZNF389 0.54 7.14 0.4 8.92e-12 Depression; CESC cis rs4319547 0.698 rs10773178 chr12:122944752 T/C cg05707623 chr12:122985044 ZCCHC8 -0.57 -7.03 -0.4 1.75e-11 Body mass index; CESC cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg25427524 chr10:38739819 LOC399744 -0.65 -9.48 -0.5 1.51e-18 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05712126 chr22:29601860 EMID1 0.57 6.11 0.35 3.54e-9 Gut microbiome composition (summer); CESC cis rs735396 0.770 rs1169300 chr12:121431225 G/A cg02403541 chr12:121454288 C12orf43 0.72 9.79 0.52 1.56e-19 N-glycan levels; CESC cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -7.48 -0.42 1.08e-12 Personality dimensions; CESC trans rs116095464 0.558 rs10077076 chr5:231940 C/T cg00938859 chr5:1591904 SDHAP3 0.63 6.87 0.39 4.49e-11 Breast cancer; CESC cis rs360071 0.528 rs360100 chr1:226067382 G/A cg17950169 chr1:226067900 TMEM63A 0.42 6.42 0.37 6.42e-10 Response to radiotherapy in prostate cancer (toxicity, rectal bleeding); CESC cis rs7903847 0.642 rs1537645 chr10:99149914 T/C cg20016023 chr10:99160130 RRP12 -0.3 -5.15 -0.3 5.04e-7 Granulocyte percentage of myeloid white cells; CESC cis rs2070997 0.702 rs3780284 chr9:133733961 A/G cg11464064 chr9:133710261 ABL1 0.55 5.98 0.34 7.32e-9 Response to amphetamines; CESC cis rs9815354 1.000 rs9875107 chr3:41822313 A/T cg03022575 chr3:42003672 ULK4 0.49 5.38 0.31 1.66e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs11195062 0.521 rs6584977 chr10:111954970 C/T cg00817464 chr10:111662876 XPNPEP1 -0.51 -6.89 -0.39 3.99e-11 Multiple myeloma; CESC cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg05315796 chr3:52349193 DNAH1 0.32 5.66 0.33 3.84e-8 Electroencephalogram traits; CESC cis rs4474465 0.688 rs4945300 chr11:78282632 T/C cg27205649 chr11:78285834 NARS2 0.52 7.25 0.41 4.65e-12 Alzheimer's disease (survival time); CESC trans rs2727020 0.521 rs7946190 chr11:49521964 T/A cg03929089 chr4:120376271 NA 0.69 7.89 0.44 8.11e-14 Coronary artery disease; CESC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs62103177 0.810 rs62103194 chr18:77629482 G/A cg12964065 chr18:77638022 KCNG2 0.58 5.46 0.32 1.07e-7 Opioid sensitivity; CESC cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg20476274 chr7:133979776 SLC35B4 0.65 9.4 0.5 2.76e-18 Mean platelet volume; CESC trans rs11098499 0.739 rs9884728 chr4:120127079 C/T cg25214090 chr10:38739885 LOC399744 -0.54 -7.16 -0.4 8.19e-12 Corneal astigmatism; CESC cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg19163074 chr7:65112434 INTS4L2 0.51 5.25 0.31 3.05e-7 Aortic root size; CESC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg00750074 chr16:89608354 SPG7 -0.42 -6.17 -0.35 2.6e-9 Multiple myeloma (IgH translocation); CESC cis rs12477438 0.798 rs6740267 chr2:99561867 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.81 -0.55 8.66e-23 Chronic sinus infection; CESC trans rs1944866 0.764 rs1944865 chr11:134479371 A/T cg26534871 chr5:108064185 NA -1.04 -6.0 -0.35 6.61e-9 Myopia (pathological); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05151241 chr15:90808880 NGRN 0.55 6.03 0.35 5.46e-9 Gut microbiome composition (summer); CESC cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg25894440 chr7:65020034 NA -0.61 -5.3 -0.31 2.42e-7 Diabetic kidney disease; CESC cis rs1797885 0.934 rs709162 chr3:12521180 T/G cg26432171 chr3:12704882 RAF1 -0.49 -6.26 -0.36 1.57e-9 Immature fraction of reticulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04203298 chr11:59521722 STX3 0.56 6.91 0.39 3.53e-11 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17408923 chr2:109335769 RANBP2 -0.44 -6.4 -0.37 6.94e-10 Gambling; CESC cis rs34779708 0.931 rs10508815 chr10:35332621 A/C cg04310649 chr10:35416472 CREM -0.53 -6.4 -0.37 6.96e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs34779708 0.931 rs2505631 chr10:35368385 A/T cg04310649 chr10:35416472 CREM 0.51 6.22 0.36 1.93e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs3857536 0.813 rs6931701 chr6:66940905 T/C cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs9929218 1.000 rs7200690 chr16:68778457 C/T cg02972257 chr16:68554789 NA 0.55 6.39 0.37 7.36e-10 Colorectal cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15622551 chr19:11039538 C19orf52;YIPF2 0.56 6.14 0.35 3e-9 Gut microbiome composition (summer); CESC cis rs9488822 0.676 rs1999929 chr6:116381994 T/C cg05304507 chr6:116381966 FRK 0.26 6.79 0.38 7.51e-11 Cholesterol, total;LDL cholesterol; CESC trans rs28549925 0.590 rs28507245 chr7:16990447 G/C cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.83e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs11864453 0.514 rs2269918 chr16:72134831 C/A cg01557791 chr16:72042693 DHODH -0.43 -5.62 -0.33 4.93e-8 Fibrinogen levels; CESC cis rs7085104 0.700 rs3740397 chr10:104592675 G/C cg04362960 chr10:104952993 NT5C2 0.48 6.12 0.35 3.31e-9 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs9300255 0.722 rs34997336 chr12:123829116 G/A cg19016782 chr12:123741754 C12orf65 0.44 6.2 0.36 2.22e-9 Neutrophil percentage of white cells; CESC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.65 9.61 0.51 6.12e-19 Total body bone mineral density; CESC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg18876405 chr7:65276391 NA 0.45 6.18 0.35 2.39e-9 Aortic root size; CESC cis rs7208859 0.673 rs2433 chr17:29226228 T/C cg19761014 chr17:28927070 LRRC37B2 0.73 5.78 0.33 2.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg24110177 chr3:50126178 RBM5 0.52 7.28 0.41 3.76e-12 Intelligence (multi-trait analysis); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19161053 chr7:99036702 CPSF4;PTCD1 0.47 6.3 0.36 1.22e-9 Systemic lupus erythematosus; CESC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg18758796 chr5:131593413 PDLIM4 0.42 5.61 0.33 5.13e-8 Acylcarnitine levels; CESC cis rs7267979 0.932 rs6115200 chr20:25487377 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.76 13.57 0.64 3.43e-32 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08591886 chr16:81111003 C16orf46 0.52 6.13 0.35 3.18e-9 Gut microbiome composition (summer); CESC cis rs6009527 0.711 rs8141990 chr22:49570455 T/G cg12746016 chr22:49560550 NA 0.44 7.54 0.42 7.27e-13 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); CESC cis rs9535495 0.833 rs7320482 chr13:51367489 C/G cg07818422 chr13:52301946 WDFY2 0.36 5.25 0.31 3.11e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs12545109 0.800 rs2118261 chr8:57393286 A/G cg09654669 chr8:57350985 NA 0.56 7.32 0.41 2.9e-12 Obesity-related traits; CESC cis rs7680126 0.633 rs11728093 chr4:10296407 A/C cg11266682 chr4:10021025 SLC2A9 -0.46 -5.96 -0.34 7.88e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs3026101 0.554 rs1806259 chr17:5315502 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.41 5.36 0.31 1.8e-7 Body mass index; CESC cis rs9900062 0.535 rs753917 chr17:62673136 C/T cg02097616 chr17:62675921 NA 0.46 5.52 0.32 8.01e-8 QT interval; CESC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg18099408 chr3:52552593 STAB1 -0.38 -6.48 -0.37 4.41e-10 Electroencephalogram traits; CESC cis rs9486719 0.857 rs11759769 chr6:97065212 G/A cg06623918 chr6:96969491 KIAA0776 -0.83 -8.95 -0.48 6.52e-17 Migraine;Coronary artery disease; CESC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg24733560 chr20:60626293 TAF4 0.45 6.44 0.37 5.45e-10 Body mass index; CESC cis rs8020095 0.528 rs73284892 chr14:67832820 A/G cg19548862 chr14:67692701 FAM71D -0.45 -5.3 -0.31 2.41e-7 Depression (quantitative trait); CESC cis rs7703051 0.901 rs5744680 chr5:74879890 C/T cg03227963 chr5:74354835 NA 0.29 5.22 0.31 3.7e-7 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CESC cis rs9467711 0.606 rs9379901 chr6:26603866 T/C cg21479132 chr6:26055353 NA 0.65 5.69 0.33 3.29e-8 Autism spectrum disorder or schizophrenia; CESC cis rs12681288 0.782 rs2600500 chr8:1029031 G/C cg15309053 chr8:964076 NA 0.37 5.77 0.33 2.15e-8 Schizophrenia; CESC cis rs7100689 0.646 rs10400045 chr10:82077032 A/G cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 4.91e-14 Post bronchodilator FEV1; CESC cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg20607287 chr7:12443886 VWDE -0.79 -9.27 -0.49 6.78e-18 Coronary artery disease; CESC cis rs4555082 0.834 rs28489970 chr14:105748862 T/C cg27165867 chr14:105738592 BRF1 -0.48 -5.1 -0.3 6.44e-7 Mean platelet volume;Platelet distribution width; CESC cis rs9916302 0.718 rs7219909 chr17:37706243 C/T cg07936489 chr17:37558343 FBXL20 -0.81 -11.66 -0.58 1.24e-25 Glomerular filtration rate (creatinine); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg04334108 chr4:148555806 TMEM184C 0.41 6.22 0.36 1.95e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg08945467 chr1:58522070 DAB1 0.47 6.0 0.35 6.33e-9 Ulcerative colitis; CESC cis rs9837602 1.000 rs1688772 chr3:99503366 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.52 -7.18 -0.4 6.88e-12 Breast cancer; CESC cis rs7937682 0.924 rs875258 chr11:111530607 C/A cg22437258 chr11:111473054 SIK2 0.69 9.29 0.5 5.71e-18 Primary sclerosing cholangitis; CESC trans rs12599106 0.715 rs34006830 chr16:34878550 C/A cg18110333 chr6:292329 DUSP22 -0.74 -9.46 -0.5 1.77e-18 Menopause (age at onset); CESC cis rs3026101 0.624 rs1806255 chr17:5314263 G/C cg25236894 chr17:5323110 RPAIN;NUP88 0.49 6.29 0.36 1.27e-9 Body mass index; CESC cis rs921968 0.541 rs933994 chr2:219650616 C/T cg02176678 chr2:219576539 TTLL4 -0.45 -7.83 -0.43 1.19e-13 Mean corpuscular hemoglobin concentration; CESC cis rs1707322 1.000 rs10890360 chr1:46338444 C/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs826838 0.935 rs3886109 chr12:39189243 C/T cg13010199 chr12:38710504 ALG10B 0.58 8.05 0.44 2.77e-14 Heart rate; CESC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg07507251 chr3:52567010 NT5DC2 0.4 6.95 0.39 2.85e-11 Bipolar disorder; CESC cis rs7208859 0.623 rs216433 chr17:28921860 T/C cg14008862 chr17:28927542 LRRC37B2 0.69 6.16 0.35 2.63e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg16680214 chr1:154839983 KCNN3 -0.52 -7.97 -0.44 4.67e-14 Prostate cancer; CESC cis rs3617 0.625 rs2240915 chr3:52859526 T/A cg11645453 chr3:52864694 ITIH4 0.25 5.2 0.3 3.93e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg20891283 chr12:69753455 YEATS4 0.9 14.79 0.67 1.71e-36 Blood protein levels; CESC cis rs2249694 0.810 rs2987785 chr10:135365003 C/T cg19469447 chr10:135341870 CYP2E1 -0.36 -5.04 -0.3 8.61e-7 Obesity-related traits; CESC cis rs523522 0.885 rs524735 chr12:121022099 T/C cg12219531 chr12:120966889 COQ5 0.76 9.91 0.52 6.54e-20 High light scatter reticulocyte count; CESC cis rs12348691 0.503 rs7046645 chr9:100617375 T/C cg13688889 chr9:100608707 NA -0.9 -13.65 -0.64 1.78e-32 Alopecia areata; CESC cis rs2777491 1.000 rs7168177 chr15:41715585 A/G cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.76 -0.51 1.94e-19 Ulcerative colitis; CESC cis rs7084402 1.000 rs717452 chr10:60268270 A/G cg07615347 chr10:60278583 BICC1 0.6 9.17 0.49 1.41e-17 Refractive error; CESC cis rs16854884 0.657 rs7610378 chr3:143711298 G/A cg06585982 chr3:143692056 C3orf58 0.5 6.44 0.37 5.45e-10 Economic and political preferences (feminism/equality); CESC cis rs5758659 0.737 rs10854749 chr22:42447341 G/T cg15557168 chr22:42548783 NA -0.45 -6.66 -0.38 1.55e-10 Cognitive function; CESC cis rs7178909 0.902 rs3853638 chr15:90443140 C/T cg19708238 chr15:90437601 AP3S2 -0.43 -6.16 -0.35 2.65e-9 Common traits (Other); CESC cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg19717773 chr7:2847554 GNA12 -0.53 -8.33 -0.46 4.37e-15 Height; CESC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg07936489 chr17:37558343 FBXL20 0.78 10.32 0.54 3.4e-21 Glomerular filtration rate (creatinine); CESC cis rs9354308 0.866 rs2814092 chr6:66547346 C/G cg07460842 chr6:66804631 NA 0.58 6.53 0.37 3.29e-10 Metabolite levels; CESC cis rs4975616 0.869 rs452384 chr5:1330840 T/C cg06550200 chr5:1325588 CLPTM1L -0.7 -11.17 -0.57 5.42e-24 Lung cancer; CESC cis rs2625529 0.652 rs2278987 chr15:72409769 T/C cg16672083 chr15:72433130 SENP8 0.45 7.06 0.4 1.49e-11 Red blood cell count; CESC cis rs4924935 0.770 rs4924946 chr17:18846525 A/T cg26378065 chr17:18585709 ZNF286B -0.46 -5.74 -0.33 2.64e-8 Pancreatic cancer; CESC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg14983838 chr19:29218262 NA 0.5 6.16 0.35 2.67e-9 Methadone dose in opioid dependence; CESC cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg11752832 chr7:134001865 SLC35B4 0.54 7.06 0.4 1.5e-11 Mean platelet volume; CESC cis rs6893300 0.961 rs7447159 chr5:179177676 G/C cg14593053 chr5:179126677 CANX -0.47 -5.04 -0.3 8.65e-7 Resting heart rate; CESC cis rs1451375 0.617 rs7790758 chr7:50561544 G/A cg14593290 chr7:50529359 DDC -0.5 -6.33 -0.36 1.04e-9 Malaria; CESC trans rs3749237 0.964 rs13084243 chr3:49821878 G/C cg21659725 chr3:3221576 CRBN 0.53 6.33 0.36 1.04e-9 Resting heart rate; CESC cis rs7605827 0.823 rs11689269 chr2:15621917 C/G cg19274914 chr2:15703543 NA 0.36 6.52 0.37 3.44e-10 Educational attainment (years of education); CESC cis rs2404602 0.647 rs11072636 chr15:77185786 A/G cg23625390 chr15:77176239 SCAPER -0.45 -6.24 -0.36 1.69e-9 Blood metabolite levels; CESC cis rs2072732 0.904 rs2993481 chr1:2973433 A/T cg15211996 chr1:2936768 ACTRT2 0.31 5.32 0.31 2.2e-7 Plateletcrit; CESC trans rs116095464 0.558 rs7730700 chr5:264713 G/A cg00938859 chr5:1591904 SDHAP3 0.63 6.77 0.38 8.38e-11 Breast cancer; CESC cis rs27434 0.583 rs26653 chr5:96139250 C/G cg16492584 chr5:96139282 ERAP1 -0.37 -5.38 -0.31 1.66e-7 Ankylosing spondylitis; CESC cis rs12142240 0.660 rs6679080 chr1:46819779 A/T cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs56235845 0.694 rs11748912 chr5:176765395 G/A cg06060754 chr5:176797920 RGS14 0.42 5.26 0.31 3.04e-7 Hemoglobin concentration;Hematocrit; CESC cis rs2425143 1.000 rs11696527 chr20:34245379 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.14 0.3 5.43e-7 Blood protein levels; CESC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg27266027 chr21:40555129 PSMG1 0.45 5.37 0.31 1.72e-7 Cognitive function; CESC cis rs7666738 0.648 rs33988750 chr4:98985386 T/C cg05340658 chr4:99064831 C4orf37 0.52 5.52 0.32 8.06e-8 Colonoscopy-negative controls vs population controls; CESC cis rs3820068 0.705 rs1800616 chr1:15832229 G/A cg18192808 chr1:15853278 DNAJC16 0.47 5.74 0.33 2.59e-8 Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14783567 chr1:244211067 NA 0.53 6.05 0.35 4.95e-9 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg20243544 chr17:37824526 PNMT 0.49 5.98 0.35 7.02e-9 Glomerular filtration rate (creatinine); CESC cis rs7772486 0.875 rs1331645 chr6:146398407 C/G cg23711669 chr6:146136114 FBXO30 0.76 10.99 0.56 2.07e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs4523957 0.855 rs12603057 chr17:2112567 T/C cg16513277 chr17:2031491 SMG6 -0.65 -8.99 -0.48 4.99e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4867766 0.711 rs76632055 chr5:173976272 C/T cg20434911 chr5:173954559 NA -0.59 -5.06 -0.3 7.86e-7 Stroke; CESC cis rs4906332 0.782 rs2236281 chr14:104000518 G/T cg04998671 chr14:104000505 TRMT61A -0.46 -5.54 -0.32 7.16e-8 Coronary artery disease; CESC cis rs1707322 0.686 rs3014235 chr1:46091512 A/G cg05343316 chr1:45956843 TESK2 -0.52 -6.53 -0.37 3.41e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20258083 chr10:93976192 CPEB3 -0.56 -6.02 -0.35 5.71e-9 Gut microbiome composition (summer); CESC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg16680214 chr1:154839983 KCNN3 -0.52 -8.13 -0.45 1.64e-14 Prostate cancer; CESC cis rs2050392 0.590 rs2065723 chr10:30720462 A/T cg02070205 chr10:30722105 MAP3K8 -0.46 -5.39 -0.31 1.59e-7 Inflammatory bowel disease; CESC trans rs9929218 0.954 rs12928043 chr16:68828885 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.02 -0.44 3.46e-14 Colorectal cancer; CESC cis rs9611565 0.921 rs4822021 chr22:41726053 G/A cg03806693 chr22:41940476 POLR3H -0.87 -9.9 -0.52 7.2e-20 Vitiligo; CESC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg27266027 chr21:40555129 PSMG1 0.47 5.81 0.34 1.75e-8 Cognitive function; CESC cis rs137699 0.687 rs4821887 chr22:39756985 C/T cg24399712 chr22:39784796 NA -0.61 -7.13 -0.4 9.54e-12 IgG glycosylation; CESC trans rs6445797 0.821 rs10212341 chr3:56669148 C/T cg15444621 chr13:113611794 NA 0.32 6.01 0.35 6.11e-9 Gastritis; CESC trans rs17742757 0.522 rs899364 chr8:11329544 G/T cg15556689 chr8:8085844 FLJ10661 -0.56 -6.31 -0.36 1.2e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs2932538 0.922 rs6681371 chr1:113101168 A/C cg22162597 chr1:113214053 CAPZA1 0.59 7.13 0.4 9.49e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs9522267 0.535 rs9522296 chr13:112234340 C/T cg10483660 chr13:112241077 NA 0.33 5.79 0.33 2.04e-8 Hepatitis; CESC cis rs9393777 0.623 rs3734544 chr6:26468660 G/A cg14345882 chr6:26364793 BTN3A2 0.44 5.46 0.32 1.11e-7 Intelligence (multi-trait analysis); CESC cis rs7940866 0.834 rs10791108 chr11:130849354 T/A cg12179176 chr11:130786555 SNX19 0.68 10.34 0.54 2.83e-21 Schizophrenia; CESC cis rs2479106 0.892 rs549779 chr9:126613028 A/G cg16191174 chr9:126692580 DENND1A -0.42 -5.32 -0.31 2.24e-7 Polycystic ovary syndrome; CESC cis rs2404602 0.669 rs1875884 chr15:76638161 C/T cg26408565 chr15:76604113 ETFA -0.42 -5.98 -0.34 7.26e-9 Blood metabolite levels; CESC cis rs6964587 0.692 rs4729018 chr7:91644613 C/T cg17063962 chr7:91808500 NA 0.46 6.55 0.37 2.91e-10 Breast cancer; CESC cis rs2637266 1.000 rs17384253 chr10:78342391 A/G cg18941641 chr10:78392320 NA 0.42 7.79 0.43 1.54e-13 Pulmonary function; CESC cis rs11583043 0.874 rs72734253 chr1:101380718 A/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.48 5.51 0.32 8.66e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs897984 0.542 rs11864839 chr16:31095251 G/C cg02466173 chr16:30829666 NA -0.41 -7.07 -0.4 1.4e-11 Dementia with Lewy bodies; CESC cis rs6582630 0.555 rs10880625 chr12:38526612 A/C cg26384229 chr12:38710491 ALG10B 0.74 11.16 0.57 6e-24 Drug-induced liver injury (flucloxacillin); CESC cis rs7680126 0.633 rs4698023 chr4:10304726 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -5.13 -0.3 5.57e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11129439 chr14:104029859 BAG5;C14orf153 -0.59 -7.68 -0.43 3.06e-13 Gut microbiome composition (summer); CESC trans rs34421088 0.560 rs2248315 chr8:11397086 T/A cg15556689 chr8:8085844 FLJ10661 -0.51 -6.0 -0.35 6.33e-9 Neuroticism; CESC cis rs11997175 0.580 rs34398087 chr8:33813800 A/G ch.8.33884649F chr8:33765107 NA -0.49 -5.84 -0.34 1.5e-8 Body mass index; CESC cis rs10129255 0.957 rs8014696 chr14:107177994 A/C cg07958169 chr14:107095056 NA 0.37 5.13 0.3 5.64e-7 Kawasaki disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26475180 chr22:41742086 ZC3H7B -0.61 -6.92 -0.39 3.43e-11 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs4901869 0.966 rs12148052 chr14:59338970 C/T cg02291164 chr14:59296302 NA 0.45 7.81 0.43 1.3e-13 Panic disorder; CESC cis rs763121 0.853 rs6001184 chr22:39052116 C/T cg06544989 chr22:39130855 UNC84B 0.49 8.52 0.46 1.22e-15 Menopause (age at onset); CESC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg24250549 chr1:154909240 PMVK 0.75 11.19 0.57 4.8e-24 Prostate cancer; CESC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg12311346 chr5:56204834 C5orf35 0.64 8.9 0.48 8.96e-17 Initial pursuit acceleration; CESC cis rs4642101 0.686 rs13085726 chr3:12832672 A/C cg05775895 chr3:12838266 CAND2 0.39 5.99 0.35 6.78e-9 QRS complex (12-leadsum); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg21087902 chr17:79234955 SLC38A10 0.4 6.11 0.35 3.52e-9 Thyroid stimulating hormone; CESC cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg12193833 chr17:30244370 NA -0.73 -6.71 -0.38 1.14e-10 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03115649 chr1:179851535 TOR1AIP1 0.53 6.18 0.35 2.47e-9 Gut microbiome composition (summer); CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg18404041 chr3:52824283 ITIH1 -0.33 -6.0 -0.35 6.5e-9 Bipolar disorder; CESC cis rs56104184 0.775 rs73063505 chr19:49402765 T/C cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs3796352 1.000 rs35576914 chr3:53092270 G/A cg07884673 chr3:53033167 SFMBT1 0.68 5.79 0.34 1.99e-8 Immune reponse to smallpox (secreted IL-2); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06310300 chr7:100076089 TSC22D4 0.49 6.54 0.37 3.13e-10 Gut microbiota (bacterial taxa); CESC cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg27286337 chr10:134555280 INPP5A 0.64 7.64 0.42 4.1e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs9435341 0.896 rs1730851 chr1:107596443 A/G cg09367891 chr1:107599246 PRMT6 -0.62 -7.49 -0.42 1.01e-12 Facial morphology (factor 21, depth of nasal alae); CESC cis rs10791097 0.935 rs4601795 chr11:130729430 T/C cg12179176 chr11:130786555 SNX19 0.56 7.97 0.44 4.59e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC trans rs17685 0.884 rs8565 chr7:75630274 T/C cg19862616 chr7:65841803 NCRNA00174 -0.67 -8.84 -0.48 1.38e-16 Coffee consumption;Coffee consumption (cups per day); CESC cis rs1775715 0.737 rs2799015 chr10:32107712 C/T cg18675610 chr10:32216311 ARHGAP12 0.33 5.1 0.3 6.52e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7674212 0.541 rs2720471 chr4:104023840 A/G cg16532752 chr4:104119610 CENPE -0.43 -5.8 -0.34 1.87e-8 Type 2 diabetes; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26434548 chr7:129074607 FAM40B -0.44 -6.33 -0.36 1.02e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs61931739 0.517 rs12815556 chr12:34319670 G/A cg19457237 chr12:34500585 NA -0.37 -5.06 -0.3 7.75e-7 Morning vs. evening chronotype; CESC cis rs2880765 0.566 rs12911430 chr15:86011264 A/T cg10818794 chr15:86012489 AKAP13 -0.36 -5.04 -0.3 8.8e-7 Coronary artery disease; CESC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg14893161 chr1:205819251 PM20D1 0.88 14.76 0.67 2.08e-36 Menarche (age at onset); CESC cis rs3820068 0.580 rs12746773 chr1:16001588 C/T cg17385448 chr1:15911702 AGMAT 0.42 6.58 0.37 2.55e-10 Systolic blood pressure; CESC cis rs7584330 0.518 rs74003103 chr2:238446699 G/A cg14458575 chr2:238380390 NA 0.67 6.31 0.36 1.16e-9 Prostate cancer; CESC cis rs4132509 0.793 rs7522883 chr1:243803022 C/T cg21452805 chr1:244014465 NA 0.63 6.63 0.38 1.85e-10 RR interval (heart rate); CESC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC trans rs1814175 0.817 rs4881648 chr11:49812901 A/G cg15704280 chr7:45808275 SEPT13 -1.02 -20.13 -0.78 2.46e-55 Height; CESC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg03538708 chr1:25844672 NA 0.36 5.42 0.32 1.36e-7 Erythrocyte sedimentation rate; CESC cis rs654950 1.000 rs654950 chr1:41987868 G/C cg06885757 chr1:42089581 HIVEP3 -0.54 -8.29 -0.45 5.91e-15 Airway imaging phenotypes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26612563 chr11:4115769 RRM1 0.55 6.02 0.35 5.7e-9 Gut microbiome composition (summer); CESC cis rs1372520 0.684 rs2619355 chr4:90748374 A/C cg15133208 chr4:90757351 SNCA -0.4 -5.34 -0.31 2.01e-7 Neuroticism; CESC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg21770322 chr7:97807741 LMTK2 0.55 8.08 0.44 2.33e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs4423214 1.000 rs2282621 chr11:71183474 C/T cg05163923 chr11:71159392 DHCR7 0.82 10.82 0.55 7.47e-23 Vitamin D levels; CESC cis rs4253772 0.938 rs77378083 chr22:46639386 G/A cg18190219 chr22:46762943 CELSR1 -0.61 -5.83 -0.34 1.64e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9300255 0.739 rs10846491 chr12:123753492 C/G cg19016782 chr12:123741754 C12orf65 -0.49 -7.07 -0.4 1.35e-11 Neutrophil percentage of white cells; CESC cis rs478304 0.934 rs570954 chr11:65498261 A/G cg08755490 chr11:65554678 OVOL1 0.47 6.21 0.36 2.06e-9 Acne (severe); CESC cis rs4660306 0.677 rs781062 chr1:45932738 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.2 0.3 4.02e-7 Homocysteine levels; CESC cis rs71277158 0.688 rs73879180 chr3:169874968 T/C cg04067573 chr3:169899625 PHC3 0.7 6.91 0.39 3.51e-11 Prostate cancer; CESC cis rs9543976 0.623 rs7982517 chr13:76162039 A/G cg01531495 chr13:76123901 UCHL3 0.51 5.14 0.3 5.32e-7 Diabetic retinopathy; CESC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg19592336 chr6:28129416 ZNF389 0.57 7.34 0.41 2.64e-12 Parkinson's disease; CESC trans rs7944735 0.671 rs7106731 chr11:48003392 T/G cg15704280 chr7:45808275 SEPT13 0.66 8.15 0.45 1.49e-14 Intraocular pressure; CESC cis rs2832191 0.791 rs7283853 chr21:30498515 G/A cg24692254 chr21:30365293 RNF160 -0.79 -12.11 -0.6 3.71e-27 Dental caries; CESC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg14391382 chr7:866102 UNC84A 0.44 5.49 0.32 9.48e-8 Subjective well-being; CESC cis rs6456156 0.583 rs7748224 chr6:167456860 C/T cg23791538 chr6:167370224 RNASET2 -0.52 -6.74 -0.38 9.89e-11 Primary biliary cholangitis; CESC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg11890956 chr21:40555474 PSMG1 1.21 24.6 0.83 2.29e-70 Cognitive function; CESC cis rs2710642 0.583 rs7421841 chr2:62880765 G/A cg17519650 chr2:63277830 OTX1 0.49 5.78 0.33 2.11e-8 LDL cholesterol levels;LDL cholesterol; CESC cis rs3091242 0.935 rs4233043 chr1:25765483 A/G cg02931644 chr1:25747376 RHCE 0.4 6.68 0.38 1.37e-10 Erythrocyte sedimentation rate; CESC trans rs11039798 0.764 rs4357721 chr11:48354907 G/A cg15704280 chr7:45808275 SEPT13 -0.67 -6.23 -0.36 1.78e-9 Axial length; CESC cis rs8016982 0.674 rs759939 chr14:81663453 G/C cg01989461 chr14:81687754 GTF2A1 0.73 11.43 0.57 7.37e-25 Schizophrenia; CESC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg16405210 chr4:1374714 KIAA1530 -0.65 -8.6 -0.47 7.07e-16 Longevity; CESC cis rs6582630 0.555 rs11182429 chr12:38526679 A/C cg26384229 chr12:38710491 ALG10B 0.67 10.53 0.54 6.77e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg02079420 chr8:82753780 SNX16 0.55 8.25 0.45 7.73e-15 Diastolic blood pressure; CESC cis rs752010 0.619 rs1123483 chr1:42114198 C/T cg12614395 chr1:42085415 HIVEP3 -0.32 -5.04 -0.3 8.68e-7 Lupus nephritis in systemic lupus erythematosus; CESC cis rs17253792 0.545 rs3742571 chr14:56016704 A/G cg01858014 chr14:56050164 KTN1 -0.82 -5.81 -0.34 1.76e-8 Putamen volume; CESC cis rs763121 0.853 rs2281020 chr22:39064406 A/G cg06544989 chr22:39130855 UNC84B 0.48 8.4 0.46 2.69e-15 Menopause (age at onset); CESC cis rs2732480 0.500 rs1552550 chr12:48643351 C/A cg24011408 chr12:48396354 COL2A1 0.44 6.22 0.36 1.95e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs2637266 0.630 rs7095225 chr10:78452623 G/T cg18941641 chr10:78392320 NA 0.39 6.87 0.39 4.48e-11 Pulmonary function; CESC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg07677032 chr17:61819896 STRADA 0.45 5.97 0.34 7.8e-9 Prudent dietary pattern; CESC cis rs7503807 1.000 rs4889775 chr17:78592287 A/G cg09596252 chr17:78655493 RPTOR 0.49 7.11 0.4 1.06e-11 Obesity; CESC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg24549020 chr5:56110836 MAP3K1 0.6 6.65 0.38 1.67e-10 Initial pursuit acceleration; CESC cis rs2816062 0.861 rs2745312 chr1:18904012 T/A cg18795169 chr1:18902165 NA -0.86 -15.54 -0.69 3.85e-39 Urate levels in lean individuals; CESC cis rs501120 1.000 rs518594 chr10:44757107 T/C cg09554077 chr10:44749378 NA 0.54 7.1 0.4 1.12e-11 Coronary artery disease;Coronary heart disease; CESC cis rs3857536 0.741 rs4710582 chr6:66939984 T/G cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.49 5.36 0.31 1.82e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2932538 0.885 rs6693880 chr1:113110261 A/G cg22162597 chr1:113214053 CAPZA1 0.55 6.96 0.39 2.59e-11 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs2370759 1.000 rs75984055 chr10:32591276 T/C cg18270830 chr10:32634957 EPC1 0.73 7.22 0.41 5.35e-12 Sexual dysfunction (female); CESC cis rs2243480 0.803 rs35268390 chr7:65416536 C/G cg18252515 chr7:66147081 NA -1.05 -10.01 -0.52 3.2e-20 Diabetic kidney disease; CESC cis rs9291683 0.510 rs4318649 chr4:10016815 T/C cg00071950 chr4:10020882 SLC2A9 0.82 13.82 0.65 4.37e-33 Bone mineral density; CESC cis rs1153858 1.000 rs4774579 chr15:45651803 G/A cg21132104 chr15:45694354 SPATA5L1 0.85 11.64 0.58 1.47e-25 Homoarginine levels; CESC cis rs10089 1.000 rs13355233 chr5:127425350 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.78 -10.51 -0.54 8.14e-22 Ileal carcinoids; CESC cis rs2839186 0.869 rs17176513 chr21:47682428 A/G cg10351095 chr21:47802916 PCNT -0.49 -6.57 -0.37 2.59e-10 Testicular germ cell tumor; CESC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg19163074 chr7:65112434 INTS4L2 0.44 5.5 0.32 9.04e-8 Aortic root size; CESC cis rs728616 0.614 rs56080607 chr10:82105964 A/T cg05935833 chr10:81318306 SFTPA2 -0.37 -5.34 -0.31 1.99e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs243505 0.559 rs10215794 chr7:148478895 C/G cg09806900 chr7:148480153 CUL1 0.45 5.35 0.31 1.89e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs11792861 0.816 rs3763643 chr9:111695607 T/C cg13535736 chr9:111863775 C9orf5 -0.47 -6.11 -0.35 3.54e-9 Menarche (age at onset); CESC cis rs6005807 0.543 rs12168849 chr22:29202063 A/G cg15103426 chr22:29168792 CCDC117 0.49 5.07 0.3 7.34e-7 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; CESC cis rs12410462 0.681 rs6681096 chr1:227609720 G/A cg23173402 chr1:227635558 NA 0.74 6.46 0.37 4.96e-10 Major depressive disorder; CESC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.64 0.33 4.43e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2708240 0.577 rs851707 chr7:147534049 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.4 -5.81 -0.34 1.81e-8 QT interval (drug interaction); CESC cis rs12142240 0.660 rs72886903 chr1:46813860 C/T cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg11148483 chr3:28393736 NA 0.41 6.07 0.35 4.36e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg09552692 chr15:66274614 MEGF11 0.43 6.2 0.36 2.15e-9 Post-traumatic stress disorder; CESC cis rs1949733 0.701 rs1880024 chr4:8454639 A/G cg11789530 chr4:8429930 ACOX3 0.76 11.12 0.56 8.15e-24 Response to antineoplastic agents; CESC cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg26874164 chr19:58962979 ZNF324B 0.54 7.47 0.42 1.2e-12 Uric acid clearance; CESC cis rs4561483 0.583 rs1019814 chr16:11940764 T/C cg08843971 chr16:11963173 GSPT1 0.45 6.28 0.36 1.4e-9 Testicular germ cell tumor; CESC trans rs1908814 0.516 rs60176945 chr8:11796674 T/C cg15556689 chr8:8085844 FLJ10661 0.52 6.37 0.36 8.4e-10 Neuroticism; CESC cis rs2354432 0.556 rs7525622 chr1:146774116 G/A cg25205988 chr1:146714368 CHD1L -0.95 -8.25 -0.45 7.34e-15 Mitochondrial DNA levels; CESC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg23758822 chr17:41437982 NA 1.04 15.72 0.69 8.6e-40 Menopause (age at onset); CESC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg00475322 chr7:917719 C7orf20 -0.47 -7.18 -0.4 7.01e-12 Perceived unattractiveness to mosquitoes; CESC cis rs11638352 1.000 rs8035212 chr15:44304636 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -5.17 -0.3 4.51e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs4925386 1.000 rs4925386 chr20:60921044 C/T cg24112000 chr20:60950667 NA -0.44 -6.35 -0.36 9.2e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs4808199 0.948 rs2301671 chr19:19466269 C/T cg03709012 chr19:19516395 GATAD2A 1.08 12.28 0.6 9.85e-28 Nonalcoholic fatty liver disease; CESC cis rs10883723 0.810 rs3818470 chr10:104263675 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.08 0.3 6.99e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.66 -0.33 3.97e-8 Depression; CESC cis rs55882075 0.634 rs11249657 chr5:179111637 G/C cg14593053 chr5:179126677 CANX 0.46 5.91 0.34 1.07e-8 Monocyte percentage of white cells; CESC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg05025164 chr4:1340916 KIAA1530 0.88 11.92 0.59 1.61e-26 Longevity; CESC cis rs61931739 0.500 rs11053249 chr12:34518834 A/T cg19457237 chr12:34500585 NA -0.37 -5.09 -0.3 6.86e-7 Morning vs. evening chronotype; CESC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg18876405 chr7:65276391 NA 0.48 5.64 0.33 4.35e-8 Aortic root size; CESC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg10541313 chr22:46663664 TTC38 0.59 5.05 0.3 8.15e-7 LDL cholesterol;Cholesterol, total; CESC cis rs5750830 0.645 rs4821890 chr22:39777523 G/A cg05872129 chr22:39784769 NA -0.72 -10.51 -0.54 7.81e-22 Intelligence (multi-trait analysis); CESC cis rs73129298 0.551 rs6012787 chr20:48594615 C/A cg25655593 chr20:48599521 SNAI1 0.46 5.15 0.3 5.05e-7 Inflammatory skin disease; CESC cis rs2274273 0.870 rs10149420 chr14:55854257 T/C cg04306507 chr14:55594613 LGALS3 0.3 5.88 0.34 1.24e-8 Protein biomarker; CESC cis rs910316 0.763 rs175044 chr14:75472109 G/A cg11812906 chr14:75593930 NEK9 -0.79 -12.34 -0.6 5.81e-28 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03951180 chr7:72742151 TRIM50;FKBP6 -0.57 -6.95 -0.39 2.78e-11 Gut microbiome composition (summer); CESC trans rs561341 0.800 rs7209766 chr17:30234848 T/A cg20587970 chr11:113659929 NA -0.65 -8.22 -0.45 8.89e-15 Hip circumference adjusted for BMI; CESC cis rs919433 0.662 rs2043018 chr2:198236958 G/A cg20885578 chr2:198174922 NA 0.41 5.38 0.31 1.66e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 9.75 0.51 2.1e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs798554 0.610 rs1182173 chr7:2878016 C/G cg19717773 chr7:2847554 GNA12 -0.51 -8.12 -0.45 1.72e-14 Height; CESC cis rs7523050 0.643 rs35526993 chr1:109405107 A/T cg08274380 chr1:109419600 GPSM2 0.85 5.82 0.34 1.74e-8 Fat distribution (HIV); CESC cis rs117623576 0.941 rs211423 chr10:32398777 A/G cg03047570 chr10:32398778 NA 0.84 8.84 0.48 1.33e-16 Anti-saccade response; CESC cis rs8060686 0.516 rs12599238 chr16:68276235 G/A cg26727032 chr16:67993705 SLC12A4 -0.51 -5.49 -0.32 9.27e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.35 5.65 0.33 4.12e-8 Monocyte percentage of white cells; CESC cis rs2050392 0.965 rs2265368 chr10:30690289 G/C cg25182066 chr10:30743637 MAP3K8 -0.37 -5.04 -0.3 8.77e-7 Inflammatory bowel disease; CESC cis rs2243480 1.000 rs67728539 chr7:65378124 G/A cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC trans rs11098499 0.820 rs28394116 chr4:120524283 T/G cg25214090 chr10:38739885 LOC399744 0.67 9.36 0.5 3.52e-18 Corneal astigmatism; CESC cis rs4803468 1.000 rs284655 chr19:41928765 C/T cg14132834 chr19:41945861 ATP5SL -0.65 -7.95 -0.44 5.44e-14 Height; CESC cis rs11583043 0.874 rs11578366 chr1:101396852 T/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.55 6.34 0.36 9.81e-10 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs763014 0.931 rs1981483 chr16:630665 G/A cg09263875 chr16:632152 PIGQ 0.67 11.14 0.56 6.6e-24 Height; CESC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg25204440 chr1:209979598 IRF6 0.64 8.11 0.45 1.94e-14 Cleft lip with or without cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26353957 chr4:47465606 COMMD8 0.57 6.33 0.36 1.04e-9 Gut microbiome composition (summer); CESC trans rs1728785 0.892 rs1170427 chr16:68603852 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.93 0.44 6e-14 Ulcerative colitis; CESC cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg23711669 chr6:146136114 FBXO30 1.02 15.62 0.69 2.01e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs9291683 0.588 rs6857693 chr4:10018435 G/A cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.73e-37 Bone mineral density; CESC cis rs11098499 0.863 rs11723090 chr4:120490592 T/C cg24375607 chr4:120327624 NA 0.48 5.95 0.34 8.26e-9 Corneal astigmatism; CESC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg13206674 chr6:150067644 NUP43 0.45 6.54 0.37 3.14e-10 Lung cancer; CESC cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg23711669 chr6:146136114 FBXO30 1.02 15.77 0.7 5.6e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs13082711 0.516 rs1492339 chr3:27371526 A/C cg02860705 chr3:27208620 NA -0.5 -6.34 -0.36 9.94e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs1215050 0.791 rs7688942 chr4:98832048 T/C cg05340658 chr4:99064831 C4orf37 0.51 6.54 0.37 3.07e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs4555082 1.000 rs4277291 chr14:105759009 A/G cg13114125 chr14:105738426 BRF1 -0.75 -9.55 -0.51 8.88e-19 Mean platelet volume;Platelet distribution width; CESC cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg19077165 chr18:44547161 KATNAL2 -0.61 -9.18 -0.49 1.27e-17 Personality dimensions; CESC cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg19077165 chr18:44547161 KATNAL2 -0.53 -7.75 -0.43 2.02e-13 Personality dimensions; CESC cis rs35306767 0.903 rs12778891 chr10:950130 T/A cg10556349 chr10:835070 NA 0.57 5.53 0.32 7.76e-8 Eosinophil percentage of granulocytes; CESC cis rs5747327 0.838 rs35945753 chr22:18156644 A/G cg19898043 chr22:18121309 BCL2L13 -0.42 -5.29 -0.31 2.62e-7 Myeloid white cell count;Granulocyte count; CESC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg11644478 chr21:40555479 PSMG1 1.01 15.98 0.7 1.06e-40 Cognitive function; CESC cis rs10782582 0.593 rs74090712 chr1:76189098 A/G cg22875332 chr1:76189707 ACADM -0.42 -5.1 -0.3 6.52e-7 Daytime sleep phenotypes; CESC cis rs8072100 0.676 rs7221345 chr17:45405144 G/A cg08085267 chr17:45401833 C17orf57 -0.66 -8.98 -0.48 5.26e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs4843747 0.605 rs28399183 chr16:88107277 G/A cg17633681 chr16:88106987 BANP 0.76 10.52 0.54 7.38e-22 Menopause (age at onset); CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg23281280 chr6:28129359 ZNF389 0.61 8.7 0.47 3.53e-16 Depression; CESC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs6570726 0.935 rs421690 chr6:145834594 A/C cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1355223 0.525 rs7129533 chr11:34872292 T/C cg11058730 chr11:34937778 PDHX;APIP -0.55 -6.64 -0.38 1.81e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs17539620 0.624 rs111484697 chr6:154838903 A/G cg17771515 chr6:154831774 CNKSR3 0.55 5.13 0.3 5.49e-7 Lipoprotein (a) levels; CESC cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg00031303 chr3:195681400 NA 0.47 5.91 0.34 1.03e-8 Pancreatic cancer; CESC cis rs9325144 0.600 rs2171405 chr12:38741030 G/T cg26384229 chr12:38710491 ALG10B -0.56 -7.86 -0.43 9.84e-14 Morning vs. evening chronotype; CESC cis rs12477438 0.501 rs1133977 chr2:99741984 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.79 -12.88 -0.62 8.43e-30 Chronic sinus infection; CESC trans rs61931739 0.890 rs1705748 chr12:34133171 A/G cg26384229 chr12:38710491 ALG10B 0.44 6.03 0.35 5.63e-9 Morning vs. evening chronotype; CESC cis rs7107174 1.000 rs10899495 chr11:78123293 C/T cg02023728 chr11:77925099 USP35 0.43 5.54 0.32 7.31e-8 Testicular germ cell tumor; CESC cis rs929354 0.709 rs1182363 chr7:157019151 A/G cg05182265 chr7:156933206 UBE3C 0.5 7.32 0.41 2.97e-12 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21649051 chr1:85514340 MCOLN3 0.57 6.38 0.36 7.93e-10 Gut microbiome composition (summer); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24448245 chr7:66461718 SBDS;TYW1 -0.46 -6.58 -0.37 2.45e-10 Gambling; CESC cis rs7937682 0.883 rs568038 chr11:111432161 A/C cg09085632 chr11:111637200 PPP2R1B 0.97 13.91 0.65 2.07e-33 Primary sclerosing cholangitis; CESC cis rs765787 0.530 rs12909987 chr15:45512207 C/T cg24006582 chr15:45444508 DUOX1 -0.45 -5.53 -0.32 7.59e-8 Uric acid levels; CESC cis rs4604732 0.631 rs10802509 chr1:247627158 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 7.17 0.4 7.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs921968 0.541 rs72965126 chr2:219330189 C/T cg02176678 chr2:219576539 TTLL4 -0.54 -9.87 -0.52 9.03e-20 Mean corpuscular hemoglobin concentration; CESC cis rs7666738 0.677 rs13120306 chr4:99036099 A/T cg17366294 chr4:99064904 C4orf37 0.62 8.62 0.47 6.05e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg07414643 chr4:187882934 NA -0.52 -6.88 -0.39 4.19e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg27401989 chr12:53774447 SP1 -0.48 -6.06 -0.35 4.69e-9 Fibrinogen levels; CESC trans rs11989744 1.000 rs17782111 chr8:23565784 A/G cg03492747 chr16:86543808 FOXF1 0.65 7.18 0.4 6.94e-12 Waist-hip ratio; CESC cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg08213375 chr14:104286397 PPP1R13B 0.31 5.2 0.3 4.07e-7 Reticulocyte count; CESC cis rs1670533 1.000 rs6599278 chr4:1058798 C/T cg27284194 chr4:1044797 NA 0.43 5.46 0.32 1.11e-7 Recombination rate (females); CESC cis rs2276314 1.000 rs4799832 chr18:33559646 T/C cg05985134 chr18:33552581 C18orf21 0.64 7.52 0.42 8.25e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs11792861 0.530 rs1772047 chr9:111679012 A/G cg05043794 chr9:111880884 C9orf5 0.31 5.41 0.32 1.42e-7 Menarche (age at onset); CESC cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.78 8.21 0.45 9.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7100689 0.577 rs873395 chr10:82037215 C/T cg00277334 chr10:82204260 NA 0.56 6.97 0.39 2.57e-11 Post bronchodilator FEV1; CESC cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg19077165 chr18:44547161 KATNAL2 -0.53 -7.79 -0.43 1.54e-13 Personality dimensions; CESC cis rs6714710 0.557 rs17490429 chr2:98449024 G/A cg26665480 chr2:98280029 ACTR1B 0.6 8.23 0.45 8.31e-15 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs7927771 0.524 rs10838763 chr11:47794802 C/T cg20307385 chr11:47447363 PSMC3 0.61 8.64 0.47 5.45e-16 Subjective well-being; CESC cis rs2857078 0.772 rs4793086 chr17:42320751 C/T cg08499158 chr17:42289980 UBTF 0.45 5.49 0.32 9.19e-8 Red cell distribution width;Reticulocyte count; CESC cis rs155076 0.711 rs4770131 chr13:21897468 A/G cg21970626 chr13:21893289 NA -0.53 -5.71 -0.33 3.02e-8 White matter hyperintensity burden; CESC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg03188948 chr7:1209495 NA 0.72 6.91 0.39 3.61e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7429990 0.965 rs7651237 chr3:48105528 A/G cg11946769 chr3:48343235 NME6 -0.61 -7.29 -0.41 3.66e-12 Educational attainment (years of education); CESC cis rs1775715 0.707 rs2808094 chr10:32133756 T/C cg18675610 chr10:32216311 ARHGAP12 0.33 5.09 0.3 6.66e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6942756 1.000 rs7780886 chr7:128879347 G/A cg02491457 chr7:128862824 NA -0.69 -9.88 -0.52 8.42e-20 White matter hyperintensity burden; CESC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.48 -0.54 9.87e-22 Alzheimer's disease; CESC trans rs35110281 0.782 rs6518309 chr21:45047992 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 6.13 0.35 3.13e-9 Mean corpuscular volume; CESC cis rs7312774 0.618 rs4964503 chr12:107335937 C/G cg16260113 chr12:107380972 MTERFD3 -0.74 -6.5 -0.37 4e-10 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27651003 chr16:67261081 TMEM208;LRRC29 -0.53 -6.42 -0.37 6.11e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11196904 chr1:10491304 APITD1 0.6 6.89 0.39 3.98e-11 Gut microbiome composition (summer); CESC cis rs17376456 0.569 rs10476520 chr5:93058290 A/C cg25358565 chr5:93447407 FAM172A 0.68 7.38 0.41 2.07e-12 Diabetic retinopathy; CESC cis rs7818688 1.000 rs28496357 chr8:96030511 T/C cg16049864 chr8:95962084 TP53INP1 0.6 5.78 0.33 2.14e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18588052 chr6:111408752 SLC16A10 -0.42 -5.99 -0.35 6.7e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24219704 chr12:107349641 C12orf23 0.51 6.03 0.35 5.48e-9 Gut microbiome composition (summer); CESC trans rs9951602 0.512 rs61021837 chr18:76648210 A/C cg02800362 chr5:177631904 HNRNPAB 0.64 8.28 0.45 5.96e-15 Obesity-related traits; CESC cis rs12249377 0.519 rs11186320 chr10:92576448 C/T cg14313238 chr10:92632228 RPP30 -0.45 -5.85 -0.34 1.44e-8 White matter microstructure (global fractional anisotropy); CESC cis rs6032067 0.777 rs35434469 chr20:43778544 C/T cg10761708 chr20:43804764 PI3 0.57 6.54 0.37 3.11e-10 Blood protein levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10668512 chr15:42565522 GANC;TMEM87A 0.55 7.28 0.41 3.89e-12 Gut microbiota (bacterial taxa); CESC cis rs2282802 0.685 rs2436391 chr5:139557385 C/T cg26211634 chr5:139558579 C5orf32 -0.48 -7.04 -0.4 1.68e-11 Intelligence (multi-trait analysis); CESC cis rs80130819 0.688 rs4760698 chr12:48592872 C/T cg05342945 chr12:48394962 COL2A1 -0.53 -6.1 -0.35 3.76e-9 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00482248 chr7:73589137 EIF4H -0.62 -7.08 -0.4 1.27e-11 Gut microbiome composition (summer); CESC cis rs2519796 0.531 rs2077384 chr9:136808454 C/T cg13751417 chr9:136814406 VAV2 -0.43 -5.55 -0.32 6.77e-8 Hematocrit;Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07156929 chr6:34856927 ANKS1A;TAF11 0.65 7.83 0.43 1.21e-13 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04618842 chr12:57472555 TMEM194A 0.42 6.09 0.35 3.95e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg08470875 chr2:26401718 FAM59B -0.76 -8.06 -0.44 2.6e-14 Gut microbiome composition (summer); CESC trans rs7395662 0.571 rs10838947 chr11:48568693 G/T cg00717180 chr2:96193071 NA -0.45 -6.19 -0.36 2.32e-9 HDL cholesterol; CESC cis rs7793919 0.726 rs10261971 chr7:4776547 A/G cg09789173 chr7:4769017 FOXK1 0.79 12.04 0.59 6.43e-27 Mosquito bite size; CESC cis rs433852 0.718 rs386551 chr19:49138286 C/G cg06677660 chr19:49140777 SEC1;DBP -0.43 -5.27 -0.31 2.87e-7 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; CESC cis rs9467773 0.595 rs12525810 chr6:26623511 T/TA cg12826209 chr6:26865740 GUSBL1 0.78 8.28 0.45 6.3e-15 Intelligence (multi-trait analysis); CESC cis rs933688 0.941 rs6452954 chr5:90735692 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.09 14.15 0.66 2.96e-34 Smoking behavior; CESC cis rs2735413 0.918 rs4888733 chr16:78080523 C/T cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs9287719 0.935 rs6751075 chr2:10723546 C/G cg02196655 chr2:10830764 NOL10 -0.36 -5.57 -0.32 6.1e-8 Prostate cancer; CESC cis rs3815700 0.844 rs444089 chr19:33106991 G/C cg02997394 chr19:33096574 ANKRD27 0.66 6.53 0.37 3.37e-10 Eosinophilic esophagitis; CESC cis rs2658782 0.547 rs3020054 chr11:93055556 C/T cg15737290 chr11:93063684 CCDC67 0.53 7.3 0.41 3.37e-12 Pulmonary function decline; CESC cis rs12220238 0.908 rs10824133 chr10:76020585 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.87 0.34 1.33e-8 Soluble interleukin-2 receptor subunit alpha; CESC cis rs11792861 0.926 rs72607170 chr9:111836941 G/A cg13535736 chr9:111863775 C9orf5 -0.51 -6.76 -0.38 8.77e-11 Menarche (age at onset); CESC cis rs796364 0.951 rs12613687 chr2:200999256 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.68 -6.65 -0.38 1.7e-10 Schizophrenia; CESC cis rs4843747 0.605 rs4072779 chr16:88107290 C/T cg06915872 chr16:87998081 BANP 0.44 5.24 0.31 3.36e-7 Menopause (age at onset); CESC cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg14500267 chr11:67383377 NA 0.36 5.71 0.33 2.99e-8 Mean corpuscular volume; CESC cis rs1065852 0.526 rs8138080 chr22:42396371 A/G cg22189786 chr22:42395067 WBP2NL -0.43 -5.34 -0.31 2e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg11764359 chr7:65958608 NA 0.81 11.81 0.59 3.86e-26 Aortic root size; CESC cis rs921968 0.541 rs41461846 chr2:219313354 A/G cg02176678 chr2:219576539 TTLL4 -0.48 -8.03 -0.44 3.23e-14 Mean corpuscular hemoglobin concentration; CESC cis rs2404602 0.552 rs11636612 chr15:76959530 C/T cg00316803 chr15:76480434 C15orf27 0.43 5.77 0.33 2.25e-8 Blood metabolite levels; CESC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg16680214 chr1:154839983 KCNN3 -0.46 -7.14 -0.4 9.24e-12 Prostate cancer; CESC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC cis rs10861342 0.892 rs12227605 chr12:105501100 G/A cg23923672 chr12:105501055 KIAA1033 0.64 5.2 0.3 4.08e-7 IgG glycosylation; CESC cis rs7923609 0.936 rs10761778 chr10:65273782 A/G cg01631684 chr10:65280961 REEP3 -0.43 -5.4 -0.31 1.47e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs3540 0.554 rs12900987 chr15:91071776 T/C cg10434728 chr15:90938212 IQGAP1 -0.4 -7.02 -0.4 1.85e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg05340658 chr4:99064831 C4orf37 0.84 13.09 0.63 1.51e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg04369109 chr6:150039330 LATS1 -0.4 -5.4 -0.31 1.48e-7 Lung cancer; CESC cis rs295140 0.506 rs295136 chr2:201141002 G/C cg23649088 chr2:200775458 C2orf69 0.46 6.16 0.35 2.67e-9 QT interval; CESC cis rs4835473 0.831 rs4452380 chr4:144894009 A/G cg25736465 chr4:144833511 NA 0.4 6.1 0.35 3.74e-9 Immature fraction of reticulocytes; CESC cis rs614226 1.000 rs580016 chr12:120933977 T/C cg01236616 chr12:121019343 POP5 -1.52 -16.63 -0.71 5.04e-43 Type 1 diabetes nephropathy; CESC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg27165867 chr14:105738592 BRF1 -0.56 -6.26 -0.36 1.51e-9 Mean platelet volume;Platelet distribution width; CESC cis rs8077577 0.895 rs11658477 chr17:18044893 G/A cg16794390 chr17:18148240 FLII 0.49 6.06 0.35 4.68e-9 Obesity-related traits; CESC cis rs11122272 0.766 rs2739511 chr1:231526490 G/C cg06096015 chr1:231504339 EGLN1 0.41 5.85 0.34 1.46e-8 Hemoglobin concentration; CESC cis rs1728785 1.000 rs1728781 chr16:68567794 A/T cg02972257 chr16:68554789 NA -0.55 -6.36 -0.36 8.6e-10 Ulcerative colitis; CESC cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg03467027 chr4:99064603 C4orf37 0.43 5.4 0.31 1.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9911578 0.900 rs7214335 chr17:57158840 G/A cg05425664 chr17:57184151 TRIM37 -0.51 -7.01 -0.4 1.98e-11 Intelligence (multi-trait analysis); CESC cis rs1953600 0.668 rs11201879 chr10:81908573 A/C cg00277334 chr10:82204260 NA 0.4 5.44 0.32 1.24e-7 Sarcoidosis; CESC cis rs12079745 0.793 rs12071122 chr1:169191749 C/A cg09363564 chr1:169337483 NME7;BLZF1 -1.01 -6.28 -0.36 1.38e-9 QT interval; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01938359 chr5:1335135 CLPTM1L 0.54 7.81 0.43 1.35e-13 Fibrinogen levels; CESC cis rs9303401 0.659 rs12946397 chr17:56769979 C/T cg10487724 chr17:56770010 TEX14;RAD51C 1.05 12.77 0.62 1.94e-29 Cognitive test performance; CESC cis rs654950 0.875 rs881719 chr1:41991427 C/T cg06885757 chr1:42089581 HIVEP3 -0.45 -6.89 -0.39 4.07e-11 Airway imaging phenotypes; CESC cis rs7503807 0.935 rs9910745 chr17:78610543 C/T cg09596252 chr17:78655493 RPTOR 0.49 7.19 0.4 6.53e-12 Obesity; CESC cis rs17253792 0.822 rs74653073 chr14:56079528 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.4 0.31 1.5e-7 Putamen volume; CESC cis rs16895831 0.549 rs1028462 chr6:42616678 G/C cg10605015 chr6:42532144 UBR2 -0.5 -5.52 -0.32 8.27e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.05 0.35 4.95e-9 Colorectal cancer; CESC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg04944784 chr2:26401820 FAM59B -0.67 -7.61 -0.42 4.8e-13 Gut microbiome composition (summer); CESC cis rs6570726 0.791 rs9322029 chr6:145906683 A/G cg05347473 chr6:146136440 FBXO30 0.58 7.59 0.42 5.51e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs6693567 0.565 rs497128 chr1:150269952 A/G cg09579323 chr1:150459698 TARS2 -0.47 -6.18 -0.35 2.44e-9 Migraine; CESC cis rs2228479 0.717 rs1800358 chr16:89809319 T/C cg06558623 chr16:89946397 TCF25 0.79 7.45 0.42 1.32e-12 Skin colour saturation; CESC trans rs7618501 0.601 rs2624825 chr3:50154989 G/A cg21659725 chr3:3221576 CRBN -0.47 -6.53 -0.37 3.44e-10 Intelligence (multi-trait analysis); CESC cis rs7084402 0.967 rs1658451 chr10:60311527 A/T cg07615347 chr10:60278583 BICC1 0.62 9.95 0.52 5.08e-20 Refractive error; CESC cis rs1784581 0.674 rs1789989 chr6:162408138 C/T cg17173639 chr6:162384350 PARK2 0.58 9.21 0.49 1.03e-17 Itch intensity from mosquito bite; CESC cis rs35110281 0.667 rs4818859 chr21:45117120 G/A cg21573476 chr21:45109991 RRP1B -0.55 -7.91 -0.44 6.87e-14 Mean corpuscular volume; CESC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg14159672 chr1:205819179 PM20D1 0.81 12.25 0.6 1.24e-27 Menarche (age at onset); CESC cis rs861020 1.000 rs622832 chr1:209974232 A/C cg05527609 chr1:210001259 C1orf107 0.93 11.26 0.57 2.76e-24 Orofacial clefts; CESC cis rs992157 0.710 rs6752254 chr2:219058743 C/T cg00012203 chr2:219082015 ARPC2 0.85 12.08 0.6 4.56e-27 Colorectal cancer; CESC cis rs80130819 0.636 rs2732451 chr12:48719946 T/C cg05342945 chr12:48394962 COL2A1 -0.49 -5.34 -0.31 2.03e-7 Prostate cancer; CESC cis rs9309473 1.000 rs6745368 chr2:73809974 C/T cg20560298 chr2:73613845 ALMS1 -0.54 -7.08 -0.4 1.27e-11 Metabolite levels; CESC cis rs2011503 0.941 rs55762233 chr19:19367319 C/G cg11584989 chr19:19387371 SF4 0.62 7.38 0.41 1.99e-12 Bipolar disorder; CESC cis rs611744 0.647 rs864166 chr8:109249300 C/G cg21045802 chr8:109455806 TTC35 0.46 5.67 0.33 3.65e-8 Dupuytren's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13910983 chr1:28241279 RPA2 -0.43 -6.13 -0.35 3.26e-9 Gut microbiota (bacterial taxa); CESC cis rs4132509 0.948 rs12136624 chr1:243981611 C/A cg21452805 chr1:244014465 NA 0.5 6.16 0.35 2.66e-9 RR interval (heart rate); CESC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg10691866 chr7:65817282 TPST1 0.32 5.45 0.32 1.18e-7 Aortic root size; CESC cis rs6867032 1.000 rs28392808 chr5:2013477 A/G cg26168224 chr5:2018326 NA 0.91 17.91 0.74 1.45e-47 Gut microbiome composition (winter); CESC cis rs9309473 1.000 rs10179134 chr2:73637519 A/G cg20560298 chr2:73613845 ALMS1 -0.54 -7.1 -0.4 1.18e-11 Metabolite levels; CESC cis rs6580649 0.941 rs72644844 chr12:48465425 A/C cg05342945 chr12:48394962 COL2A1 0.51 5.91 0.34 1.07e-8 Lung cancer; CESC cis rs7267979 0.899 rs442834 chr20:25458096 A/G cg08601574 chr20:25228251 PYGB 0.37 5.36 0.31 1.77e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2806561 0.929 rs628096 chr1:23537676 C/G cg12483005 chr1:23474871 LUZP1 0.32 5.15 0.3 4.99e-7 Height; CESC cis rs965513 1.000 rs4743130 chr9:100546040 C/T cg13688889 chr9:100608707 NA -0.6 -8.5 -0.46 1.37e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03304299 chr22:17565742 IL17RA -0.46 -6.05 -0.35 4.98e-9 Fibrinogen levels; CESC cis rs2625529 0.652 rs2929517 chr15:72332917 T/G cg16672083 chr15:72433130 SENP8 0.38 5.67 0.33 3.79e-8 Red blood cell count; CESC trans rs116095464 0.614 rs4371799 chr5:268192 C/A cg00938859 chr5:1591904 SDHAP3 0.63 6.89 0.39 4.18e-11 Breast cancer; CESC cis rs826838 1.000 rs1684416 chr12:39130301 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.26 -0.36 1.51e-9 Heart rate; CESC cis rs798766 0.779 rs3134866 chr4:1723265 A/G cg10756475 chr4:1757242 NA 0.45 6.2 0.36 2.15e-9 Bladder cancer;Urinary bladder cancer; CESC cis rs9462846 0.959 rs7750915 chr6:42882067 C/T cg02353165 chr6:42928485 GNMT 0.5 5.64 0.33 4.28e-8 Blood protein levels; CESC cis rs10883723 0.810 rs7079810 chr10:104243883 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.52 0.42 8.75e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg23048001 chr7:2026167 MAD1L1 0.45 5.92 0.34 9.84e-9 Schizophrenia; CESC cis rs9863 0.828 rs12303671 chr12:124492610 T/G cg00084347 chr12:124393913 DNAH10 0.26 5.15 0.3 5.05e-7 White blood cell count; CESC cis rs3820928 0.874 rs67513858 chr2:227804819 A/C cg05526886 chr2:227700861 RHBDD1 -0.39 -5.04 -0.3 8.54e-7 Pulmonary function; CESC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg24531977 chr5:56204891 C5orf35 -0.75 -9.36 -0.5 3.47e-18 Initial pursuit acceleration; CESC cis rs6582630 0.502 rs1607876 chr12:38355750 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.77 0.33 2.24e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs11989744 0.957 rs61099147 chr8:23573953 A/G cg03492747 chr16:86543808 FOXF1 0.68 7.61 0.42 4.92e-13 Waist-hip ratio; CESC cis rs2050392 0.544 rs598672 chr10:30742388 C/T cg25182066 chr10:30743637 MAP3K8 -0.54 -7.56 -0.42 6.81e-13 Inflammatory bowel disease; CESC cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg06636001 chr8:8085503 FLJ10661 0.59 7.27 0.41 4.14e-12 Systolic blood pressure; CESC cis rs694739 0.894 rs887314 chr11:64053157 T/G cg23796481 chr11:64053134 BAD;GPR137 0.66 8.35 0.46 3.96e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs6754311 0.731 rs309134 chr2:136755684 A/G cg07169764 chr2:136633963 MCM6 -0.72 -9.22 -0.49 9.75e-18 Mosquito bite size; CESC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg21951975 chr1:209979733 IRF6 0.6 9.51 0.5 1.25e-18 Cleft lip with or without cleft palate; CESC cis rs116988415 0.584 rs77587730 chr14:65237285 C/A cg25083366 chr14:65239357 SPTB 0.8 5.68 0.33 3.58e-8 Daytime sleep phenotypes; CESC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg02018176 chr4:1364513 KIAA1530 0.45 6.34 0.36 1.01e-9 Longevity; CESC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg17971929 chr21:40555470 PSMG1 1.05 16.62 0.71 5.49e-43 Cognitive function; CESC cis rs1707322 0.685 rs56177313 chr1:46225806 A/C cg03146154 chr1:46216737 IPP 0.81 11.44 0.58 6.59e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7923452 0.507 rs612802 chr10:30756441 G/A cg18806716 chr10:30721971 MAP3K8 -0.54 -8.2 -0.45 1.03e-14 Itch intensity from mosquito bite; CESC cis rs17253792 0.822 rs9972178 chr14:56073480 A/G cg01858014 chr14:56050164 KTN1 -0.85 -6.99 -0.39 2.22e-11 Putamen volume; CESC cis rs9858542 0.953 rs11711485 chr3:49491983 G/T cg07274523 chr3:49395745 GPX1 0.65 8.0 0.44 3.84e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 8.47 0.46 1.68e-15 Platelet count; CESC cis rs4423214 0.840 rs1792234 chr11:71182018 T/C cg05163923 chr11:71159392 DHCR7 -0.68 -8.01 -0.44 3.74e-14 Vitamin D levels; CESC cis rs561341 1.000 rs521919 chr17:30298039 G/T cg19193384 chr17:30244184 NA -0.6 -6.23 -0.36 1.78e-9 Hip circumference adjusted for BMI; CESC cis rs7914558 1.000 rs12255047 chr10:104760752 G/A cg04362960 chr10:104952993 NT5C2 0.45 6.0 0.35 6.3e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs3008870 0.785 rs10889651 chr1:67463513 A/T cg02640540 chr1:67518911 SLC35D1 -0.45 -5.5 -0.32 8.85e-8 Lymphocyte percentage of white cells; CESC cis rs6570726 0.846 rs372904 chr6:145887425 T/C cg23711669 chr6:146136114 FBXO30 0.92 13.93 0.65 1.83e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs644799 0.965 rs3016295 chr11:95554311 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.42 0.37 6.39e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg27347728 chr4:17578864 LAP3 0.43 5.12 0.3 5.92e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10931896 0.531 rs295117 chr2:201146828 C/T cg23649088 chr2:200775458 C2orf69 0.53 7.34 0.41 2.62e-12 Systolic blood pressure; CESC cis rs7918232 0.882 rs6415983 chr10:27357211 A/G cg14240646 chr10:27532245 ACBD5 -0.55 -5.1 -0.3 6.51e-7 Breast cancer; CESC cis rs1843834 0.931 rs10170573 chr2:225552916 A/G cg22455342 chr2:225449267 CUL3 0.53 6.56 0.37 2.86e-10 IgE levels in asthmatics (D.p. specific); CESC trans rs875971 0.660 rs10263935 chr7:66096028 A/G cg26939375 chr7:64535504 NA 0.53 7.13 0.4 9.73e-12 Aortic root size; CESC cis rs12477438 0.520 rs6542864 chr2:99725223 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 16.04 0.7 6.57e-41 Chronic sinus infection; CESC cis rs34779708 0.931 rs72789609 chr10:35306206 C/T cg04310649 chr10:35416472 CREM -0.48 -5.84 -0.34 1.53e-8 Inflammatory bowel disease;Crohn's disease; CESC cis rs763014 0.932 rs4984898 chr16:641164 G/T cg00802000 chr16:706648 WDR90 -0.37 -5.31 -0.31 2.35e-7 Height; CESC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg17372223 chr3:52568218 NT5DC2 0.43 6.49 0.37 4.15e-10 Electroencephalogram traits; CESC cis rs4481887 1.000 rs10788782 chr1:248496132 C/A cg00666640 chr1:248458726 OR2T12 0.41 6.57 0.37 2.64e-10 Common traits (Other); CESC cis rs4969178 0.896 rs11077361 chr17:76397128 A/G cg20026190 chr17:76395443 PGS1 0.49 7.78 0.43 1.67e-13 HDL cholesterol levels; CESC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg08859206 chr1:53392774 SCP2 -0.57 -7.56 -0.42 6.6e-13 Monocyte count; CESC cis rs3784262 0.967 rs11630835 chr15:58269462 C/T cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.07 -0.3 7.49e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs9467711 0.606 rs13203358 chr6:26590578 A/T cg12826209 chr6:26865740 GUSBL1 0.66 5.67 0.33 3.73e-8 Autism spectrum disorder or schizophrenia; CESC cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg19418458 chr7:158789849 NA -0.47 -7.59 -0.42 5.51e-13 Facial morphology (factor 20); CESC cis rs1879734 0.731 rs11206192 chr1:54158690 A/G cg23596471 chr1:54105337 GLIS1 -0.32 -5.12 -0.3 5.76e-7 Mitral valve prolapse; CESC cis rs858239 0.601 rs10224327 chr7:23161820 T/C cg23682824 chr7:23144976 KLHL7 0.49 6.5 0.37 4.06e-10 Cerebrospinal fluid biomarker levels; CESC trans rs7307889 0.546 rs10160866 chr12:6014627 G/T cg18407955 chr7:158110685 PTPRN2 -0.71 -6.58 -0.37 2.48e-10 Obesity-related traits; CESC cis rs1348850 0.540 rs10172355 chr2:178443225 A/G cg23306229 chr2:178417860 TTC30B 0.59 5.7 0.33 3.22e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs854765 0.583 rs9890341 chr17:17823175 G/C cg04398451 chr17:18023971 MYO15A -0.67 -9.6 -0.51 6.42e-19 Total body bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03794219 chr15:84954280 NA -0.41 -6.92 -0.39 3.4e-11 Gut microbiota (bacterial taxa); CESC cis rs7103648 0.669 rs7114011 chr11:47811309 A/C cg20307385 chr11:47447363 PSMC3 0.81 12.27 0.6 1.04e-27 Diastolic blood pressure;Systolic blood pressure; CESC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg17158414 chr2:27665306 KRTCAP3 -0.32 -5.99 -0.35 6.73e-9 Total body bone mineral density; CESC cis rs6456156 0.586 rs9459853 chr6:167465774 C/A cg07741184 chr6:167504864 NA 0.37 6.34 0.36 9.82e-10 Primary biliary cholangitis; CESC cis rs10779751 1.000 rs12124983 chr1:11286178 C/T cg08854313 chr1:11322531 MTOR -0.92 -14.48 -0.66 2.19e-35 Body mass index; CESC cis rs5769765 0.778 rs4574208 chr22:50256738 C/T cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.79e-8 Schizophrenia; CESC cis rs921968 0.643 rs598701 chr2:219387005 C/G cg02176678 chr2:219576539 TTLL4 -0.34 -5.91 -0.34 1.06e-8 Mean corpuscular hemoglobin concentration; CESC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg07332563 chr6:291687 DUSP22 -0.7 -9.13 -0.49 1.77e-17 Menopause (age at onset); CESC cis rs8180040 0.966 rs6765990 chr3:47542894 G/A cg27129171 chr3:47204927 SETD2 0.6 8.92 0.48 7.91e-17 Colorectal cancer; CESC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg11764359 chr7:65958608 NA 0.82 10.05 0.53 2.44e-20 Aortic root size; CESC cis rs4849845 0.849 rs12711940 chr2:121036386 T/A cg24070213 chr2:121070622 NA 0.4 5.13 0.3 5.63e-7 Mean platelet volume; CESC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg18230493 chr5:56204884 C5orf35 -0.74 -9.05 -0.49 3.27e-17 Initial pursuit acceleration; CESC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg05132306 chr1:1846340 CALML6 -0.29 -6.06 -0.35 4.58e-9 Body mass index; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17017335 chr3:97540665 NA -0.47 -6.73 -0.38 1.02e-10 Gambling; CESC cis rs3733585 0.781 rs4292328 chr4:9970962 C/T cg11266682 chr4:10021025 SLC2A9 -0.62 -12.53 -0.61 1.38e-28 Cleft plate (environmental tobacco smoke interaction); CESC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg24675658 chr1:53192096 ZYG11B 0.54 7.53 0.42 7.86e-13 Monocyte count; CESC cis rs4975709 0.609 rs2232373 chr5:1882280 C/G cg12288994 chr5:1860383 NA 0.36 5.63 0.33 4.48e-8 Cardiovascular disease risk factors; CESC cis rs4474465 0.850 rs10793327 chr11:78256841 A/C cg27205649 chr11:78285834 NARS2 0.43 5.42 0.32 1.37e-7 Alzheimer's disease (survival time); CESC cis rs9457247 0.646 rs4710160 chr6:167409241 T/A cg25258033 chr6:167368657 RNASET2 0.4 6.14 0.35 2.93e-9 Crohn's disease; CESC cis rs2637266 1.000 rs7905033 chr10:78368212 A/C cg18941641 chr10:78392320 NA 0.43 8.26 0.45 6.94e-15 Pulmonary function; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05926606 chr21:40685342 BRWD1 -0.44 -6.01 -0.35 6.11e-9 Fibrinogen levels; CESC cis rs2204008 0.720 rs11170774 chr12:38021722 C/T cg26384229 chr12:38710491 ALG10B -0.54 -7.65 -0.43 3.79e-13 Bladder cancer; CESC cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg04166393 chr7:2884313 GNA12 0.4 5.21 0.3 3.81e-7 Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01174859 chr7:128379317 CALU 0.45 6.15 0.35 2.88e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4237845 0.514 rs4760339 chr12:58268149 G/T cg04478727 chr12:58166393 METTL1;FAM119B 0.5 5.62 0.33 4.83e-8 Intelligence (multi-trait analysis); CESC cis rs9640161 0.789 rs36035506 chr7:150057843 C/T cg27494647 chr7:150038898 RARRES2 0.42 5.12 0.3 5.75e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs7680126 0.596 rs10022911 chr4:10140551 A/G cg11266682 chr4:10021025 SLC2A9 -0.46 -6.08 -0.35 4.14e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC trans rs1945213 0.694 rs12422168 chr11:55866840 A/G cg03929089 chr4:120376271 NA 0.73 6.92 0.39 3.43e-11 Acute lymphoblastic leukemia (childhood); CESC cis rs2239547 0.522 rs2581815 chr3:52982159 C/G cg11645453 chr3:52864694 ITIH4 0.33 5.5 0.32 9.05e-8 Schizophrenia; CESC cis rs748404 0.697 rs475261 chr15:43546456 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.87 0.44 8.86e-14 Lung cancer; CESC cis rs12142240 0.698 rs66911505 chr1:46823298 A/G cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.09e-9 Menopause (age at onset); CESC trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg15704280 chr7:45808275 SEPT13 -0.82 -12.5 -0.61 1.69e-28 Coronary artery disease; CESC cis rs9948 0.881 rs7580942 chr2:97468276 C/G cg01990225 chr2:97406019 LMAN2L -0.54 -5.2 -0.3 4.09e-7 Erectile dysfunction and prostate cancer treatment; CESC cis rs10484885 0.878 rs72921937 chr6:90579863 T/G cg13799429 chr6:90582589 CASP8AP2 -0.79 -7.55 -0.42 7.1e-13 QRS interval (sulfonylurea treatment interaction); CESC cis rs7267979 0.844 rs6107017 chr20:25232300 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.72 11.88 0.59 2.28e-26 Liver enzyme levels (alkaline phosphatase); CESC cis rs9287719 0.967 rs4284804 chr2:10722124 C/T cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.35e-8 Prostate cancer; CESC cis rs3106136 0.527 rs2632411 chr4:95149434 G/A cg11021082 chr4:95130006 SMARCAD1 -0.7 -11.58 -0.58 2.35e-25 Capecitabine sensitivity; CESC cis rs7267979 1.000 rs2297496 chr20:25295787 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -18.7 -0.75 2.48e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs9443645 0.527 rs7756996 chr6:79509367 A/C cg05283184 chr6:79620031 NA -0.36 -5.29 -0.31 2.62e-7 Intelligence (multi-trait analysis); CESC cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg08645402 chr16:4508243 NA 0.43 6.3 0.36 1.23e-9 Schizophrenia; CESC cis rs7786808 0.741 rs11767875 chr7:158228923 A/G cg09998033 chr7:158218633 PTPRN2 -0.43 -6.44 -0.37 5.71e-10 Obesity-related traits; CESC trans rs11992162 0.933 rs10108075 chr8:11832079 A/G cg15556689 chr8:8085844 FLJ10661 0.54 6.18 0.35 2.39e-9 Monocyte count; CESC cis rs3749237 0.595 rs17595772 chr3:49409704 G/A cg07636037 chr3:49044803 WDR6 0.62 8.98 0.48 5.18e-17 Resting heart rate; CESC cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.38 5.48 0.32 9.96e-8 Schizophrenia; CESC cis rs7824557 0.628 rs7815802 chr8:11190647 G/C cg21775007 chr8:11205619 TDH 0.55 8.63 0.47 5.8e-16 Retinal vascular caliber; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24162330 chr15:28520159 HERC2 -0.37 -6.19 -0.36 2.24e-9 Gambling; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg19056506 chr17:79633562 CCDC137;C17orf90 0.51 6.24 0.36 1.77e-9 Psoriatic arthritis; CESC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg07677032 chr17:61819896 STRADA 0.47 6.31 0.36 1.16e-9 Prudent dietary pattern; CESC cis rs9467711 0.606 rs9358935 chr6:26369587 A/G cg14345882 chr6:26364793 BTN3A2 0.6 6.21 0.36 2.06e-9 Autism spectrum disorder or schizophrenia; CESC cis rs818427 0.593 rs3317 chr5:112212151 G/A cg07820702 chr5:112228657 REEP5 0.39 5.1 0.3 6.36e-7 Total body bone mineral density; CESC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg20862496 chr8:143823734 SLURP1 0.34 5.27 0.31 2.9e-7 Urinary tract infection frequency; CESC cis rs7647973 0.600 rs13064780 chr3:49274826 T/G cg07636037 chr3:49044803 WDR6 0.8 13.11 0.63 1.37e-30 Menarche (age at onset); CESC cis rs7647973 0.626 rs4855845 chr3:49687043 T/C cg07636037 chr3:49044803 WDR6 0.54 6.47 0.37 4.79e-10 Menarche (age at onset); CESC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.06 -13.11 -0.63 1.37e-30 Gut microbiome composition (summer); CESC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg12648201 chr2:27665141 KRTCAP3 -0.32 -5.68 -0.33 3.62e-8 Total body bone mineral density; CESC cis rs16866061 0.517 rs7594223 chr2:225472985 T/C cg12698349 chr2:225449008 CUL3 0.46 5.99 0.35 6.67e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs2361718 0.500 rs8068856 chr17:78100731 A/G cg27427491 chr17:78079615 GAA -0.39 -5.75 -0.33 2.44e-8 Yeast infection; CESC cis rs9457247 0.756 rs1811123 chr6:167403443 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.83 0.34 1.59e-8 Crohn's disease; CESC cis rs1775715 0.737 rs11008695 chr10:32216887 T/G cg26784012 chr10:32216390 ARHGAP12 0.38 5.08 0.3 7.1e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg23978390 chr7:1156363 C7orf50 0.53 7.11 0.4 1.08e-11 Longevity;Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08399230 chr16:4665037 FAM100A 0.63 7.53 0.42 7.93e-13 Gut microbiome composition (summer); CESC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg08392591 chr16:89556376 ANKRD11 0.52 6.81 0.39 6.38e-11 Multiple myeloma (IgH translocation); CESC cis rs9910055 0.529 rs228765 chr17:42186422 C/T cg13607699 chr17:42295918 UBTF -0.44 -5.51 -0.32 8.36e-8 Total body bone mineral density; CESC cis rs1153858 0.943 rs8038342 chr15:45651537 T/C cg14582100 chr15:45693742 SPATA5L1 0.42 5.97 0.34 7.62e-9 Homoarginine levels; CESC cis rs3091242 0.933 rs909833 chr1:25754140 C/G cg03538708 chr1:25844672 NA -0.41 -6.29 -0.36 1.29e-9 Erythrocyte sedimentation rate; CESC cis rs2370759 1.000 rs76998371 chr10:32631785 A/G cg05361325 chr10:32636312 EPC1 -0.56 -5.21 -0.3 3.82e-7 Sexual dysfunction (female); CESC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg15664640 chr17:80829946 TBCD -0.68 -9.62 -0.51 5.39e-19 Breast cancer; CESC cis rs3741404 0.609 rs635139 chr11:63872210 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 9.9 0.52 7.1e-20 Platelet count; CESC cis rs12477438 0.520 rs13022329 chr2:99731189 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.87 0.7 2.48e-40 Chronic sinus infection; CESC cis rs9902453 1.000 rs4465650 chr17:28396721 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.36 0.46 3.69e-15 Coffee consumption (cups per day); CESC cis rs881375 0.678 rs10818488 chr9:123705087 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.82 0.39 6.25e-11 Rheumatoid arthritis; CESC cis rs3820928 0.845 rs7570869 chr2:227878818 A/C cg11843606 chr2:227700838 RHBDD1 -0.48 -6.15 -0.35 2.84e-9 Pulmonary function; CESC cis rs258892 0.895 rs10042574 chr5:72085684 C/G cg21869765 chr5:72125136 TNPO1 -0.42 -5.42 -0.32 1.36e-7 Small cell lung carcinoma; CESC cis rs8058578 0.614 rs2878304 chr16:30878366 C/T cg02466173 chr16:30829666 NA 0.45 6.57 0.37 2.65e-10 Multiple myeloma; CESC cis rs11650494 0.710 rs73987293 chr17:47474728 A/G cg08112188 chr17:47440006 ZNF652 0.83 6.31 0.36 1.17e-9 Prostate cancer; CESC cis rs4308124 0.708 rs10179596 chr2:111970380 G/A cg04571233 chr2:111982156 NA -0.62 -6.8 -0.39 6.82e-11 Vitiligo; CESC cis rs3820068 0.559 rs6675334 chr1:15923580 A/T cg13390004 chr1:15929781 NA 0.33 5.31 0.31 2.33e-7 Systolic blood pressure; CESC cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg06713675 chr4:122721982 EXOSC9 -0.45 -6.39 -0.37 7.46e-10 Type 2 diabetes; CESC cis rs13385 0.769 rs13188675 chr5:139606718 G/A cg26211634 chr5:139558579 C5orf32 0.47 5.16 0.3 4.78e-7 Atrial fibrillation; CESC cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg12927641 chr6:109611667 NA 0.44 6.82 0.39 6.1e-11 Reticulocyte fraction of red cells; CESC cis rs6445797 0.855 rs35467279 chr3:56567152 C/A cg13792233 chr3:56591045 CCDC66 -0.38 -5.18 -0.3 4.44e-7 Gastritis; CESC cis rs6831352 0.734 rs1453872 chr4:100022482 G/A cg13256891 chr4:100009986 ADH5 0.7 8.18 0.45 1.17e-14 Alcohol dependence; CESC cis rs6987853 0.527 rs2974298 chr8:42376477 T/C cg09913449 chr8:42400586 C8orf40 -0.35 -5.58 -0.32 5.96e-8 Mean corpuscular hemoglobin concentration; CESC cis rs116095464 0.558 rs13354585 chr5:242263 G/C cg22496380 chr5:211416 CCDC127 -0.74 -8.68 -0.47 4.09e-16 Breast cancer; CESC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.79 10.49 0.54 9.34e-22 Height; CESC cis rs11785400 0.793 rs4581034 chr8:143736968 G/A cg24634471 chr8:143751801 JRK 0.46 5.91 0.34 1.04e-8 Schizophrenia; CESC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg11764359 chr7:65958608 NA 0.89 13.96 0.65 1.41e-33 Aortic root size; CESC cis rs7772486 0.686 rs857877 chr6:145976230 A/C cg05347473 chr6:146136440 FBXO30 -0.55 -7.1 -0.4 1.12e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs3780486 1.000 rs10813957 chr9:33153527 G/T cg13443165 chr9:33130375 B4GALT1 0.42 5.23 0.31 3.48e-7 IgG glycosylation; CESC cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg03467027 chr4:99064603 C4orf37 0.46 5.82 0.34 1.74e-8 Colonoscopy-negative controls vs population controls; CESC cis rs523522 0.962 rs509445 chr12:121017243 A/C cg27279351 chr12:120934652 DYNLL1 0.69 8.92 0.48 7.73e-17 High light scatter reticulocyte count; CESC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 6.42 0.37 6.2e-10 Prudent dietary pattern; CESC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.21 0.6 1.71e-27 Alzheimer's disease; CESC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg11644478 chr21:40555479 PSMG1 -0.53 -7.17 -0.4 7.64e-12 Menarche (age at onset); CESC cis rs9611565 0.559 rs6002408 chr22:41967870 C/T cg06634786 chr22:41940651 POLR3H -0.59 -6.29 -0.36 1.29e-9 Vitiligo; CESC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg17724175 chr1:150552817 MCL1 -0.43 -6.96 -0.39 2.6e-11 Tonsillectomy; CESC trans rs28549925 0.590 rs66681092 chr7:16989244 C/T cg12639933 chr12:57626296 SHMT2 0.95 6.1 0.35 3.83e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.54 0.32 7.45e-8 Bipolar disorder; CESC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg16545954 chr1:2118288 C1orf86 -0.34 -6.15 -0.35 2.79e-9 Height; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg02988255 chr11:60621110 GPR44 0.39 6.0 0.35 6.35e-9 Cleft plate (environmental tobacco smoke interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01570069 chr10:96305623 HELLS 0.46 6.06 0.35 4.68e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9488822 0.676 rs12524249 chr6:116368813 G/A cg18764771 chr6:116381957 FRK 0.23 5.72 0.33 2.83e-8 Cholesterol, total;LDL cholesterol; CESC cis rs2070997 0.756 rs7872328 chr9:133727453 T/A cg11464064 chr9:133710261 ABL1 0.56 6.07 0.35 4.53e-9 Response to amphetamines; CESC cis rs2243480 0.901 rs313808 chr7:65499873 T/G cg18252515 chr7:66147081 NA -1.13 -10.91 -0.56 3.9e-23 Diabetic kidney disease; CESC cis rs67478160 0.644 rs7159810 chr14:104294117 T/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.53 0.54 6.84e-22 Schizophrenia; CESC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg23758822 chr17:41437982 NA 1.0 14.95 0.68 4.7e-37 Menopause (age at onset); CESC cis rs3106136 0.903 rs35361491 chr4:95202492 G/A cg11021082 chr4:95130006 SMARCAD1 -0.47 -6.94 -0.39 3.03e-11 Capecitabine sensitivity; CESC cis rs7789940 0.857 rs12532935 chr7:75939698 G/C cg10167463 chr7:75959203 YWHAG -0.47 -5.64 -0.33 4.42e-8 Multiple sclerosis; CESC trans rs11098499 0.535 rs10005542 chr4:120268302 T/C cg25214090 chr10:38739885 LOC399744 0.59 8.14 0.45 1.55e-14 Corneal astigmatism; CESC cis rs8099014 0.648 rs4940704 chr18:56115507 A/G cg12827950 chr18:55968429 NEDD4L -0.47 -5.06 -0.3 7.79e-7 Platelet count; CESC cis rs6430585 0.527 rs76380759 chr2:136438517 G/A cg07169764 chr2:136633963 MCM6 1.08 12.35 0.6 5.71e-28 Corneal structure; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg03425468 chr1:155164676 MIR92B -0.47 -6.25 -0.36 1.67e-9 Ulcerative colitis; CESC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg18252515 chr7:66147081 NA -0.48 -6.45 -0.37 5.25e-10 Aortic root size; CESC cis rs6963495 0.745 rs73190179 chr7:105162812 C/A cg02135003 chr7:105160482 PUS7 -0.46 -5.55 -0.32 6.92e-8 Bipolar disorder (body mass index interaction); CESC cis rs11048434 0.673 rs2159961 chr12:9061456 G/T cg04155231 chr12:9217510 LOC144571 0.31 5.08 0.3 7.3e-7 Sjögren's syndrome; CESC cis rs7666738 0.753 rs11932536 chr4:98930105 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -5.03 -0.3 8.96e-7 Glomerular filtration rate (creatinine); CESC cis rs9527 0.590 rs2148200 chr10:104879847 C/A cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs4891159 0.790 rs72973773 chr18:74115176 T/C cg24786174 chr18:74118243 ZNF516 -0.72 -11.24 -0.57 3.28e-24 Longevity; CESC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg04267008 chr7:1944627 MAD1L1 0.6 7.16 0.4 7.71e-12 Bipolar disorder and schizophrenia; CESC cis rs7772486 0.875 rs6913797 chr6:146413758 A/G cg05347473 chr6:146136440 FBXO30 0.49 6.63 0.38 1.83e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs2777491 0.874 rs28716108 chr15:41655523 G/C cg18705301 chr15:41695430 NDUFAF1 -0.67 -10.15 -0.53 1.13e-20 Ulcerative colitis; CESC cis rs787274 0.543 rs10739377 chr9:115631598 A/G cg13803584 chr9:115635662 SNX30 0.64 5.98 0.34 7.3e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg16325326 chr1:53192061 ZYG11B -0.84 -14.58 -0.67 9.51e-36 Monocyte count; CESC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg18032046 chr6:28092343 ZSCAN16 -0.55 -6.8 -0.39 7.12e-11 Parkinson's disease; CESC cis rs9487051 1.000 rs1008084 chr6:109626965 G/A cg01475377 chr6:109611718 NA -0.4 -6.08 -0.35 4.24e-9 Reticulocyte fraction of red cells; CESC trans rs3780486 0.846 rs10971438 chr9:33180308 A/G cg20290983 chr6:43655470 MRPS18A 0.86 12.64 0.61 5.48e-29 IgG glycosylation; CESC cis rs6942756 1.000 rs6467243 chr7:129001508 A/G cg02491457 chr7:128862824 NA -0.67 -9.42 -0.5 2.27e-18 White matter hyperintensity burden; CESC cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.07 0.3 7.39e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg06715928 chr10:112257500 DUSP5 0.41 6.02 0.35 5.68e-9 Vertical cup-disc ratio; CESC cis rs2273669 0.667 rs12154092 chr6:109313303 C/T cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs8020095 0.528 rs10132093 chr14:67847511 G/A cg19548862 chr14:67692701 FAM71D -0.45 -5.3 -0.31 2.41e-7 Depression (quantitative trait); CESC cis rs7259376 0.869 rs11671804 chr19:22591216 A/G cg02657401 chr19:22469223 NA 0.27 5.55 0.32 6.97e-8 Menopause (age at onset); CESC cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.76 7.37 0.41 2.13e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.81 0.39 6.64e-11 Bipolar disorder; CESC cis rs854765 0.583 rs62064156 chr17:17822480 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.36 0.36 8.96e-10 Total body bone mineral density; CESC cis rs9399135 0.967 rs1041480 chr6:135373076 G/T cg22676075 chr6:135203613 NA 0.52 7.3 0.41 3.39e-12 Red blood cell count; CESC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.03e-11 Tonsillectomy; CESC cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg23711669 chr6:146136114 FBXO30 0.95 14.33 0.66 7.03e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs8058578 0.945 rs8058961 chr16:30809063 G/A cg02466173 chr16:30829666 NA -0.47 -7.49 -0.42 1.03e-12 Multiple myeloma; CESC trans rs2727020 0.731 rs10450572 chr11:49281073 T/C cg03929089 chr4:120376271 NA 0.8 12.07 0.6 5.09e-27 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15606819 chr19:49661083 TRPM4 0.62 7.3 0.41 3.4e-12 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12931616 chr22:38528856 PLA2G6 0.44 6.16 0.35 2.65e-9 Fibrinogen levels; CESC cis rs79349575 0.783 rs962272 chr17:46978283 A/G cg26022315 chr17:47021804 SNF8 0.38 5.03 0.3 9.14e-7 Type 2 diabetes; CESC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg11890956 chr21:40555474 PSMG1 -0.63 -8.8 -0.48 1.76e-16 Menarche (age at onset); CESC cis rs1018836 0.608 rs7821069 chr8:91465548 C/G cg16814680 chr8:91681699 NA -0.5 -6.99 -0.39 2.18e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9457247 0.967 rs2757054 chr6:167380501 A/G cg25258033 chr6:167368657 RNASET2 -0.42 -6.24 -0.36 1.77e-9 Crohn's disease; CESC cis rs1003719 0.715 rs6517405 chr21:38560334 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -8.29 -0.45 5.68e-15 Eye color traits; CESC cis rs79349575 0.756 rs3848460 chr17:47047114 A/G cg16584676 chr17:46985605 UBE2Z -0.44 -5.48 -0.32 1.01e-7 Type 2 diabetes; CESC cis rs4891159 0.790 rs1787448 chr18:74113179 T/C cg24786174 chr18:74118243 ZNF516 0.76 12.11 0.6 3.83e-27 Longevity; CESC cis rs9902453 0.808 rs56216220 chr17:28209182 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.08 0.44 2.31e-14 Coffee consumption (cups per day); CESC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg22143856 chr6:28129313 ZNF389 0.49 6.16 0.35 2.76e-9 Depression; CESC cis rs2228479 0.850 rs11642010 chr16:89845111 T/C cg04013166 chr16:89971882 TCF25 0.76 6.05 0.35 5.02e-9 Skin colour saturation; CESC cis rs11608355 0.515 rs2287191 chr12:109931741 C/T cg05360138 chr12:110035743 NA 0.82 8.85 0.48 1.27e-16 Neuroticism; CESC cis rs3806843 0.966 rs2563260 chr5:140137867 C/A cg26395211 chr5:140044315 WDR55 0.44 5.6 0.33 5.41e-8 Depressive symptoms (multi-trait analysis); CESC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg11301795 chr4:187892539 NA -0.75 -12.3 -0.6 8.03e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs8077577 0.747 rs62072541 chr17:18226699 G/A cg16794390 chr17:18148240 FLII 0.4 6.34 0.36 9.98e-10 Obesity-related traits; CESC cis rs9612 1.000 rs7246677 chr19:44248625 G/A cg08581076 chr19:44259116 C19orf61 0.59 6.7 0.38 1.26e-10 Exhaled nitric oxide output; CESC cis rs11997175 0.603 rs7001603 chr8:33680978 T/G ch.8.33884649F chr8:33765107 NA 0.57 7.38 0.41 2.01e-12 Body mass index; CESC cis rs10504073 0.647 rs7817571 chr8:50003218 T/C cg00325661 chr8:49890786 NA 0.51 7.78 0.43 1.65e-13 Blood metabolite ratios; CESC cis rs7216064 0.954 rs4790974 chr17:65951107 A/T cg12091567 chr17:66097778 LOC651250 0.72 8.17 0.45 1.3e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs643506 0.874 rs634983 chr11:111747427 C/T cg17089665 chr11:111648010 NA -0.38 -5.51 -0.32 8.29e-8 Breast cancer; CESC cis rs9388451 0.869 rs7764016 chr6:126070789 T/G cg10911889 chr6:126070802 HEY2 0.39 5.34 0.31 1.97e-7 Brugada syndrome; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02466933 chr2:9770529 YWHAQ 0.56 6.78 0.38 7.99e-11 Gut microbiome composition (summer); CESC cis rs4950322 0.570 rs945742 chr1:146785157 A/G cg16700924 chr1:146552102 NA -0.41 -5.1 -0.3 6.37e-7 Protein quantitative trait loci; CESC cis rs7666738 0.830 rs35685312 chr4:98858521 G/A cg03467027 chr4:99064603 C4orf37 0.42 5.16 0.3 4.73e-7 Colonoscopy-negative controls vs population controls; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13009927 chr2:242254519 SEPT2;HDLBP -0.42 -6.08 -0.35 4.27e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs910316 1.000 rs4322591 chr14:75600697 C/T cg08847533 chr14:75593920 NEK9 1.01 19.64 0.77 1.26e-53 Height; CESC cis rs919433 0.750 rs788010 chr2:198230949 T/C cg20885578 chr2:198174922 NA 0.41 5.36 0.31 1.79e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4604732 0.631 rs12038793 chr1:247624262 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 -0.52 -6.6 -0.38 2.22e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2404602 0.692 rs7350777 chr15:76985441 G/A cg22467129 chr15:76604101 ETFA -0.34 -5.12 -0.3 5.9e-7 Blood metabolite levels; CESC cis rs3796352 1.000 rs3097417 chr3:53088601 C/G cg07884673 chr3:53033167 SFMBT1 -0.64 -5.87 -0.34 1.31e-8 Immune reponse to smallpox (secreted IL-2); CESC cis rs2075371 0.932 rs11766132 chr7:133993062 T/C cg20476274 chr7:133979776 SLC35B4 0.63 8.97 0.48 5.48e-17 Mean platelet volume; CESC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg04287289 chr16:89883240 FANCA -0.77 -11.54 -0.58 3.18e-25 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08701028 chr2:54880931 SPTBN1 0.49 6.43 0.37 5.85e-10 Fibrinogen levels; CESC cis rs4604732 0.578 rs12040725 chr1:247644697 T/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.45 5.75 0.33 2.48e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg11764359 chr7:65958608 NA -0.54 -7.08 -0.4 1.31e-11 Aortic root size; CESC cis rs1035144 0.506 rs2371416 chr14:81275672 A/T cg06600135 chr14:81408086 NA -0.54 -7.17 -0.4 7.51e-12 Male sexual orientation; CESC cis rs2658782 0.789 rs2259633 chr11:93141580 C/A cg15737290 chr11:93063684 CCDC67 0.45 5.34 0.31 2.04e-7 Pulmonary function decline; CESC cis rs3857067 0.806 rs6817795 chr4:95127716 T/A cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.21 -0.49 1.06e-17 QT interval; CESC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg07507251 chr3:52567010 NT5DC2 0.37 6.9 0.39 3.85e-11 Bipolar disorder; CESC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg20735954 chr22:39777886 SYNGR1 -0.41 -5.23 -0.31 3.43e-7 Intelligence (multi-trait analysis); CESC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg19774624 chr17:42201019 HDAC5 -0.88 -14.07 -0.65 5.68e-34 Total body bone mineral density; CESC cis rs9916302 0.821 rs412430 chr17:37737094 C/G cg07936489 chr17:37558343 FBXL20 -0.79 -10.99 -0.56 2.18e-23 Glomerular filtration rate (creatinine); CESC cis rs17376456 0.569 rs6556834 chr5:93123067 C/T cg21475434 chr5:93447410 FAM172A -0.5 -5.1 -0.3 6.36e-7 Diabetic retinopathy; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg14906455 chr17:2628088 NA 0.48 6.37 0.36 8.23e-10 Systemic lupus erythematosus; CESC cis rs1953600 0.645 rs2819945 chr10:81952956 G/A cg00277334 chr10:82204260 NA 0.54 7.95 0.44 5.46e-14 Sarcoidosis; CESC cis rs7927771 0.832 rs10838698 chr11:47385923 G/A cg05585544 chr11:47624801 NA 0.49 7.14 0.4 8.83e-12 Subjective well-being; CESC cis rs1506636 1.000 rs2402669 chr7:123297460 C/G cg03229431 chr7:123269106 ASB15 -0.52 -6.72 -0.38 1.09e-10 Plateletcrit;Platelet count; CESC cis rs2299587 0.623 rs12718384 chr8:17781112 T/C cg08627089 chr8:17753878 FGL1 -0.4 -5.37 -0.31 1.7e-7 Economic and political preferences; CESC cis rs11711311 0.955 rs12630833 chr3:113390883 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.66 8.62 0.47 6.11e-16 IgG glycosylation; CESC cis rs6570726 1.000 rs444564 chr6:145859795 G/C cg23711669 chr6:146136114 FBXO30 0.76 11.1 0.56 9.21e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg06212747 chr3:49208901 KLHDC8B 0.73 9.87 0.52 9.15e-20 Parkinson's disease; CESC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.47 0.42 1.14e-12 Tonsillectomy; CESC cis rs28374715 0.578 rs10518717 chr15:41623368 C/G cg02330683 chr15:41787940 ITPKA 0.46 5.42 0.32 1.36e-7 Ulcerative colitis; CESC cis rs11148252 0.595 rs9526974 chr13:53251040 C/G cg00495681 chr13:53174319 NA 0.56 7.58 0.42 5.68e-13 Lewy body disease; CESC trans rs1814175 0.817 rs1319547 chr11:49916705 C/T cg03929089 chr4:120376271 NA -0.93 -15.69 -0.69 1.12e-39 Height; CESC cis rs2285947 1.000 rs10228845 chr7:21583617 G/A cg04471919 chr7:21584483 DNAH11 0.31 5.16 0.3 4.73e-7 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); CESC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 10.21 0.53 7.43e-21 Mean platelet volume; CESC cis rs9388451 0.839 rs4897155 chr6:126095144 C/A cg10911889 chr6:126070802 HEY2 0.36 5.09 0.3 6.91e-7 Brugada syndrome; CESC cis rs62229266 0.804 rs11088331 chr21:37421872 T/C cg12218747 chr21:37451666 NA -0.43 -6.09 -0.35 3.99e-9 Mitral valve prolapse; CESC cis rs9399135 0.967 rs9399129 chr6:135285148 C/A cg22676075 chr6:135203613 NA 0.51 7.07 0.4 1.41e-11 Red blood cell count; CESC cis rs7666738 0.830 rs9998682 chr4:98939009 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7044106 0.762 rs10760115 chr9:123476952 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.07 0.35 4.38e-9 Hip circumference adjusted for BMI; CESC cis rs7412746 0.611 rs2256355 chr1:150811794 A/G cg17724175 chr1:150552817 MCL1 0.33 5.24 0.31 3.23e-7 Melanoma; CESC trans rs2018683 0.835 rs7782264 chr7:28978986 A/G cg19402173 chr7:128379420 CALU 0.55 7.5 0.42 9.72e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs938554 0.692 rs4428284 chr4:9996392 A/T cg11266682 chr4:10021025 SLC2A9 0.5 6.44 0.37 5.74e-10 Blood metabolite levels; CESC cis rs1448094 0.621 rs10863089 chr12:86279699 C/T cg02569458 chr12:86230093 RASSF9 0.42 6.14 0.35 3.03e-9 Major depressive disorder; CESC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg02463440 chr8:22132932 PIWIL2 0.36 5.46 0.32 1.08e-7 Hypertriglyceridemia; CESC cis rs3733585 0.673 rs4519796 chr4:9955936 A/G cg00071950 chr4:10020882 SLC2A9 -0.69 -11.31 -0.57 1.83e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6732160 0.932 rs6546803 chr2:73381315 C/G cg01422370 chr2:73384389 NA 0.51 8.77 0.47 2.15e-16 Intelligence (multi-trait analysis); CESC cis rs4689388 0.581 rs11727100 chr4:6281458 A/C cg14416269 chr4:6271139 WFS1 0.41 5.23 0.31 3.47e-7 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1577917 1.000 rs12665321 chr6:86769289 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.14 -0.35 3.04e-9 Response to antipsychotic treatment; CESC cis rs6815814 0.731 rs11735251 chr4:38773057 T/A cg02016764 chr4:38805732 TLR1 -0.44 -6.08 -0.35 4.24e-9 Breast cancer; CESC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg03806693 chr22:41940476 POLR3H -1.18 -16.09 -0.7 4.22e-41 Vitiligo; CESC cis rs2933343 0.700 rs789239 chr3:128633808 T/C cg11901034 chr3:128598214 ACAD9 -0.39 -5.71 -0.33 3.07e-8 IgG glycosylation; CESC cis rs881375 0.967 rs7864019 chr9:123692868 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 5.14 0.3 5.24e-7 Rheumatoid arthritis; CESC cis rs929354 0.772 rs10229630 chr7:157004790 C/T cg05182265 chr7:156933206 UBE3C -0.49 -7.15 -0.4 8.25e-12 Body mass index; CESC cis rs6460942 0.591 rs6945587 chr7:12356992 G/A cg06484146 chr7:12443880 VWDE -0.62 -6.64 -0.38 1.72e-10 Coronary artery disease; CESC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg04518342 chr5:131593106 PDLIM4 0.4 5.96 0.34 7.99e-9 Acylcarnitine levels; CESC cis rs116095464 0.558 rs6555052 chr5:224268 G/A cg10591111 chr5:226296 SDHA -0.52 -6.52 -0.37 3.47e-10 Breast cancer; CESC cis rs7666738 0.649 rs28865589 chr4:98954279 C/A cg05340658 chr4:99064831 C4orf37 0.79 11.79 0.59 4.35e-26 Colonoscopy-negative controls vs population controls; CESC cis rs4604732 0.631 rs75600450 chr1:247625492 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.5 6.29 0.36 1.29e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs2404602 0.692 rs12595586 chr15:77172210 A/G cg26408565 chr15:76604113 ETFA -0.39 -5.68 -0.33 3.63e-8 Blood metabolite levels; CESC cis rs4242434 0.927 rs2291231 chr8:22463912 C/T cg03733263 chr8:22462867 KIAA1967 0.94 15.78 0.7 5.38e-40 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs62432291 0.681 rs388001 chr6:159658459 C/T cg14500486 chr6:159655392 FNDC1 -0.62 -6.34 -0.36 9.83e-10 Joint mobility (Beighton score); CESC cis rs3820928 0.845 rs10165767 chr2:227781863 G/A cg11843606 chr2:227700838 RHBDD1 -0.49 -6.55 -0.37 2.93e-10 Pulmonary function; CESC cis rs1005277 0.540 rs289638 chr10:37923731 G/A cg25517755 chr10:38738941 LOC399744 -0.41 -5.34 -0.31 1.99e-7 Extrinsic epigenetic age acceleration; CESC cis rs2204008 0.628 rs10876106 chr12:37990767 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.68 0.33 3.46e-8 Bladder cancer; CESC cis rs3105593 1.000 rs2174608 chr15:50871993 T/A cg08437265 chr15:50716283 USP8 0.4 5.22 0.31 3.57e-7 QT interval; CESC cis rs7620457 1.000 rs7620457 chr3:183747266 A/G cg01324343 chr3:183735012 ABCC5 -0.47 -6.01 -0.35 6.24e-9 Body mass index; CESC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.72 0.38 1.13e-10 Bipolar disorder; CESC cis rs3845702 1.000 rs259808 chr2:180791419 T/G cg01881094 chr2:180872142 CWC22 -0.7 -7.18 -0.4 6.96e-12 Schizophrenia; CESC cis rs524281 0.692 rs11227395 chr11:65829637 A/C cg14036092 chr11:66035641 RAB1B -0.56 -6.19 -0.36 2.29e-9 Electroencephalogram traits; CESC cis rs7084402 0.967 rs1649060 chr10:60310480 C/G cg07615347 chr10:60278583 BICC1 -0.59 -8.88 -0.48 1.07e-16 Refractive error; CESC cis rs7666738 0.546 rs13105521 chr4:98734419 C/T cg17366294 chr4:99064904 C4orf37 0.53 6.64 0.38 1.78e-10 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg18876405 chr7:65276391 NA -0.57 -7.64 -0.42 3.94e-13 Aortic root size; CESC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg22920501 chr2:26401640 FAM59B 0.78 7.93 0.44 6.01e-14 Gut microbiome composition (summer); CESC cis rs3008870 0.920 rs1925413 chr1:67417101 T/C cg02640540 chr1:67518911 SLC35D1 0.51 5.54 0.32 7.41e-8 Lymphocyte percentage of white cells; CESC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg18876405 chr7:65276391 NA -0.67 -9.41 -0.5 2.43e-18 Aortic root size; CESC cis rs763014 0.898 rs8060921 chr16:635988 C/A cg09263875 chr16:632152 PIGQ 0.68 11.61 0.58 1.81e-25 Height; CESC cis rs12701220 0.857 rs869412 chr7:1074134 T/C cg26769984 chr7:1090371 C7orf50 0.67 7.64 0.42 4.07e-13 Bronchopulmonary dysplasia; CESC cis rs3096299 0.748 rs3102339 chr16:89442711 C/T cg16743903 chr16:89593216 SPG7 -0.44 -5.57 -0.32 6.32e-8 Multiple myeloma (IgH translocation); CESC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.56 0.37 2.81e-10 Bipolar disorder; CESC cis rs6570726 0.935 rs451349 chr6:145820894 A/G cg23711669 chr6:146136114 FBXO30 0.81 12.04 0.59 6.44e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs4925386 0.681 rs2427296 chr20:60927475 G/A cg22633769 chr20:60982531 CABLES2 0.56 5.95 0.34 8.51e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs6991838 0.584 rs7463740 chr8:66486185 G/A cg13398993 chr8:66546079 ARMC1 -0.45 -5.54 -0.32 7.3900000000000007e-08 Intelligence (multi-trait analysis); CESC cis rs1348850 0.567 rs7605609 chr2:178534942 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.01 0.4 2.02e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3857536 0.740 rs7766407 chr6:66885658 C/A cg07460842 chr6:66804631 NA -0.42 -5.39 -0.31 1.53e-7 Blood trace element (Cu levels); CESC cis rs7560272 0.538 rs4852975 chr2:73932465 C/T cg20560298 chr2:73613845 ALMS1 0.46 6.27 0.36 1.48e-9 Schizophrenia; CESC cis rs7537660 0.929 rs4607924 chr1:248004848 G/C cg12080717 chr1:248004886 OR11L1 -0.46 -5.69 -0.33 3.29e-8 Platelet distribution width; CESC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 5.58 0.32 5.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8067354 0.958 rs2333563 chr17:57839568 A/G cg13753209 chr17:57696993 CLTC 0.51 6.85 0.39 5.04e-11 Hemoglobin concentration; CESC cis rs228437 1.000 rs450801 chr6:134905309 T/C cg24504307 chr6:134963096 NA 0.52 5.52 0.32 8.27e-8 Melanoma; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02701985 chr7:100888300 FIS1 -0.5 -6.24 -0.36 1.76e-9 Asthma; CESC cis rs5769765 0.908 rs9616370 chr22:50306316 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.59 6.3 0.36 1.27e-9 Schizophrenia; CESC cis rs1215050 0.740 rs783941 chr4:99008235 T/C cg05340658 chr4:99064831 C4orf37 -0.56 -7.6 -0.42 4.97e-13 Waist-to-hip ratio adjusted for body mass index; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg05514743 chr19:14629124 DNAJB1 -0.54 -6.42 -0.37 6.23e-10 Ulcerative colitis; CESC cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg19717773 chr7:2847554 GNA12 -0.55 -8.64 -0.47 5.48e-16 Height; CESC cis rs7647973 1.000 rs11928090 chr3:49604904 G/A cg07636037 chr3:49044803 WDR6 0.71 10.04 0.52 2.62e-20 Menarche (age at onset); CESC cis rs1941023 0.503 rs4939349 chr11:60135880 G/A cg08716584 chr11:60157161 MS4A7 -0.54 -8.74 -0.47 2.67e-16 Congenital heart disease (maternal effect); CESC cis rs55728055 0.661 rs12168645 chr22:32061014 G/A cg01338084 chr22:32026380 PISD 1.15 8.18 0.45 1.22e-14 Age-related hearing impairment; CESC cis rs2243480 1.000 rs419603 chr7:65597341 C/T cg18252515 chr7:66147081 NA -1.41 -14.36 -0.66 5.44e-35 Diabetic kidney disease; CESC cis rs6456156 0.586 rs2017338 chr6:167471714 G/A cg07741184 chr6:167504864 NA 0.36 6.21 0.36 2.01e-9 Primary biliary cholangitis; CESC cis rs1562975 0.609 rs60290218 chr4:109409501 A/G cg16022748 chr4:109541635 LOC285456;RPL34 0.42 5.4 0.32 1.45e-7 Height; CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg18032046 chr6:28092343 ZSCAN16 -0.56 -6.34 -0.36 9.9e-10 Depression; CESC cis rs1964356 0.967 rs2953802 chr8:8851881 G/A cg06636001 chr8:8085503 FLJ10661 0.4 5.3 0.31 2.42e-7 Mean corpuscular volume; CESC trans rs1814175 0.559 rs1818892 chr11:49863084 C/A cg15704280 chr7:45808275 SEPT13 -1.0 -18.78 -0.76 1.35e-50 Height; CESC cis rs501120 1.000 rs522293 chr10:44756703 G/A cg09554077 chr10:44749378 NA 0.52 6.91 0.39 3.59e-11 Coronary artery disease;Coronary heart disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10145585 chr7:2443058 CHST12 0.62 7.49 0.42 1.04e-12 Gut microbiome composition (summer); CESC trans rs6651255 0.657 rs12679359 chr8:130724556 G/T cg14074285 chr4:4868908 NA -0.44 -6.07 -0.35 4.44e-9 Sciatica caused by lumbar disc herniation (treated with microdiscectomy); CESC cis rs9911578 1.000 rs2270097 chr17:56572070 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.41 -5.46 -0.32 1.08e-7 Intelligence (multi-trait analysis); CESC trans rs10028773 0.700 rs7671797 chr4:120248157 A/G cg25214090 chr10:38739885 LOC399744 0.62 8.69 0.47 3.79e-16 Educational attainment; CESC cis rs34734847 1.000 rs10431385 chr12:121128882 T/C cg21892295 chr12:121157589 UNC119B -0.37 -5.84 -0.34 1.5e-8 Mean corpuscular volume; CESC cis rs5995756 0.688 rs11705236 chr22:40010682 G/A cg03390717 chr22:39966585 CACNA1I -0.29 -5.05 -0.3 8.27e-7 Autism spectrum disorder or schizophrenia; CESC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.8e-8 Aortic root size; CESC cis rs372883 0.564 rs766928 chr21:30753606 A/G cg24692254 chr21:30365293 RNF160 0.5 6.18 0.35 2.43e-9 Pancreatic cancer; CESC cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.2 0.3 4.03e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72634258 0.945 rs36016881 chr1:8051241 A/G cg00042356 chr1:8021962 PARK7 0.83 7.58 0.42 5.96e-13 Inflammatory bowel disease; CESC cis rs2732480 0.577 rs2634693 chr12:48706498 C/T cg24011408 chr12:48396354 COL2A1 0.43 5.91 0.34 1.07e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs1707322 0.821 rs10749857 chr1:46248143 C/T cg05343316 chr1:45956843 TESK2 0.48 5.87 0.34 1.3e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg05835009 chr4:710272 PCGF3 0.42 5.35 0.31 1.92e-7 White blood cell count; CESC cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg20701182 chr2:24300061 SF3B14 0.94 10.39 0.54 2.01e-21 Lymphocyte counts; CESC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.63 -8.01 -0.44 3.68e-14 Alzheimer's disease; CESC cis rs1879734 0.773 rs1465037 chr1:54135078 C/A cg23596471 chr1:54105337 GLIS1 0.35 5.44 0.32 1.19e-7 Mitral valve prolapse; CESC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg19163074 chr7:65112434 INTS4L2 0.48 5.78 0.33 2.06e-8 Aortic root size; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03341697 chr11:94277138 FUT4 0.49 6.43 0.37 5.8e-10 Systemic lupus erythematosus; CESC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg07701084 chr6:150067640 NUP43 0.45 6.26 0.36 1.54e-9 Lung cancer; CESC cis rs6546550 0.694 rs12467361 chr2:70019127 G/A cg02498382 chr2:70120550 SNRNP27 -0.34 -5.76 -0.33 2.33e-8 Prevalent atrial fibrillation; CESC cis rs1707322 0.716 rs28370457 chr1:46172062 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3213545 0.700 rs10849829 chr12:121470256 A/G cg15155738 chr12:121454335 C12orf43 -0.47 -5.78 -0.33 2.13e-8 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg11764359 chr7:65958608 NA -0.7 -9.27 -0.49 6.71e-18 Aortic root size; CESC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg06873352 chr17:61820015 STRADA 0.73 12.41 0.61 3.42e-28 Prudent dietary pattern; CESC cis rs10791097 0.690 rs12284540 chr11:130729772 T/C cg12179176 chr11:130786555 SNX19 0.58 8.5 0.46 1.41e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg19077165 chr18:44547161 KATNAL2 -0.61 -9.1 -0.49 2.27e-17 Personality dimensions; CESC cis rs4268898 0.931 rs55642516 chr2:24502305 A/G cg06627628 chr2:24431161 ITSN2 -0.7 -8.58 -0.47 7.87e-16 Asthma; CESC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.54 -0.37 3.08e-10 Bipolar disorder; CESC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg06873352 chr17:61820015 STRADA 0.71 12.15 0.6 2.65e-27 Prudent dietary pattern; CESC cis rs3733585 0.699 rs4588456 chr4:9963895 A/T cg11266682 chr4:10021025 SLC2A9 -0.6 -11.2 -0.57 4.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6088580 0.524 rs7269596 chr20:33229063 T/C cg08999081 chr20:33150536 PIGU -0.45 -6.37 -0.36 8.42e-10 Glomerular filtration rate (creatinine); CESC cis rs72781680 1.000 rs72796339 chr2:24143063 T/C cg08917208 chr2:24149416 ATAD2B 0.93 8.42 0.46 2.35e-15 Lymphocyte counts; CESC cis rs12048904 0.595 rs10493937 chr1:101342650 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.66 -9.5 -0.5 1.33e-18 Multiple sclerosis; CESC cis rs6545883 0.931 rs778768 chr2:61790289 C/G cg15711740 chr2:61764176 XPO1 -0.43 -5.16 -0.3 4.84e-7 Tuberculosis; CESC cis rs7851660 0.967 rs1443435 chr9:100617583 T/C cg13688889 chr9:100608707 NA -0.69 -10.57 -0.54 4.92e-22 Strep throat; CESC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg21770322 chr7:97807741 LMTK2 0.58 8.55 0.47 9.84e-16 Prostate cancer (SNP x SNP interaction); CESC cis rs4253772 0.591 rs6008538 chr22:46685963 G/A cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.57 5.83 0.34 1.59e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7208859 0.623 rs7503335 chr17:29073962 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2425143 1.000 rs7273668 chr20:34442731 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.66 5.72 0.33 2.88e-8 Blood protein levels; CESC trans rs1605070 1.000 rs1587922 chr3:51918228 C/T cg17926940 chr14:97685060 NA 0.35 6.25 0.36 1.66e-9 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2050392 1.000 rs7077496 chr10:30692028 G/A cg18806716 chr10:30721971 MAP3K8 0.44 6.25 0.36 1.64e-9 Inflammatory bowel disease; CESC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg10691866 chr7:65817282 TPST1 -0.33 -5.41 -0.32 1.44e-7 Aortic root size; CESC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg22508957 chr16:3507546 NAT15 -0.64 -6.84 -0.39 5.58e-11 Tuberculosis; CESC cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg08807892 chr2:162101083 NA 0.47 6.35 0.36 9.31e-10 Intelligence (multi-trait analysis); CESC cis rs4253772 0.530 rs6008662 chr22:46713917 G/A cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.62 6.5 0.37 4.02e-10 LDL cholesterol;Cholesterol, total; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12049088 chr22:36784491 MYH9 0.43 6.17 0.35 2.56e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1707322 0.963 rs10789478 chr1:46350506 C/T cg06784218 chr1:46089804 CCDC17 0.35 5.91 0.34 1.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4835473 0.932 rs2323417 chr4:144890261 T/C cg25736465 chr4:144833511 NA 0.4 6.27 0.36 1.49e-9 Immature fraction of reticulocytes; CESC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg14393609 chr7:65229607 NA -0.45 -6.02 -0.35 5.91e-9 Aortic root size; CESC cis rs4523957 0.928 rs394752 chr17:2199749 C/A cg16513277 chr17:2031491 SMG6 0.63 8.49 0.46 1.48e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg04944784 chr2:26401820 FAM59B -0.93 -10.7 -0.55 1.94e-22 Gut microbiome composition (summer); CESC cis rs2742234 0.504 rs7093409 chr10:43740067 A/G cg07801480 chr10:43725741 RASGEF1A -0.41 -5.41 -0.32 1.42e-7 Hirschsprung disease; CESC cis rs13191362 0.507 rs2023038 chr6:163119280 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.52 -6.32 -0.36 1.08e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7621025 0.505 rs61789643 chr3:136109752 G/T cg15507776 chr3:136538369 TMEM22 -0.73 -5.84 -0.34 1.56e-8 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs735396 0.770 rs2464196 chr12:121435427 G/A cg25281562 chr12:121454272 C12orf43 0.53 6.79 0.38 7.44e-11 N-glycan levels; CESC cis rs589448 0.867 rs623853 chr12:69753830 G/A cg22834771 chr12:69754056 YEATS4 -0.55 -7.21 -0.41 5.72e-12 Cerebrospinal fluid biomarker levels; CESC cis rs4319547 0.619 rs10744208 chr12:122931559 C/A cg05707623 chr12:122985044 ZCCHC8 -0.5 -5.77 -0.33 2.19e-8 Body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20506460 chr20:43150682 SERINC3 0.47 6.15 0.35 2.89e-9 Gut microbiota (bacterial taxa); CESC cis rs12971120 0.947 rs8084109 chr18:72168312 T/A cg26446133 chr18:72167187 CNDP2 -0.74 -11.03 -0.56 1.55e-23 Refractive error; CESC cis rs7264396 0.580 rs2425173 chr20:34445142 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -9.5 -0.5 1.31e-18 Total cholesterol levels; CESC cis rs60843830 1.000 rs57542652 chr2:228088 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.86 11.08 0.56 1.11e-23 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7945705 0.967 rs1569408 chr11:8909732 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.51 8.18 0.45 1.2e-14 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27481639 chr12:66524651 LLPH 0.57 6.09 0.35 3.99e-9 Gut microbiome composition (summer); CESC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg00310523 chr12:86230176 RASSF9 -0.36 -5.81 -0.34 1.76e-8 Major depressive disorder; CESC cis rs896543 0.702 rs12692188 chr2:237495929 A/G cg25295825 chr2:237489920 CXCR7 0.7 9.1 0.49 2.19e-17 Alcohol dependence (age at onset); CESC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2070488 0.804 rs35463537 chr3:38498248 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 12.54 0.61 1.2e-28 Electrocardiographic conduction measures; CESC cis rs4077515 0.967 rs4075760 chr9:139266697 A/G cg14169450 chr9:139327907 INPP5E 0.35 5.11 0.3 6.31e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs6500395 1.000 rs3817029 chr16:48584942 C/T cg04672837 chr16:48644449 N4BP1 0.51 6.32 0.36 1.13e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1707322 1.000 rs785468 chr1:46521517 G/A cg05343316 chr1:45956843 TESK2 -0.44 -5.44 -0.32 1.2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10129255 0.500 rs8022547 chr14:107190222 A/T cg07958169 chr14:107095056 NA -0.53 -8.39 -0.46 2.85e-15 Kawasaki disease; CESC cis rs9905704 0.918 rs304271 chr17:56802458 C/T cg12560992 chr17:57184187 TRIM37 0.59 7.06 0.4 1.45e-11 Testicular germ cell tumor; CESC cis rs6691722 0.583 rs7535482 chr1:24695114 A/C cg02336364 chr1:24764700 NIPAL3 0.27 5.65 0.33 4.22e-8 Response to interferon beta in multiple sclerosis; CESC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg23978390 chr7:1156363 C7orf50 0.5 6.92 0.39 3.3e-11 Longevity;Endometriosis; CESC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg24112000 chr20:60950667 NA 0.47 6.75 0.38 9.47e-11 Colorectal cancer; CESC cis rs11098499 0.866 rs9991221 chr4:120292107 G/C cg24375607 chr4:120327624 NA 0.42 5.19 0.3 4.19e-7 Corneal astigmatism; CESC cis rs7937682 0.961 rs491937 chr11:111494947 A/T cg22437258 chr11:111473054 SIK2 0.71 9.73 0.51 2.44e-19 Primary sclerosing cholangitis; CESC cis rs10927875 0.632 rs4481843 chr1:16128205 G/A cg05821634 chr1:16164109 FLJ37453 0.35 5.04 0.3 8.77e-7 Dilated cardiomyopathy; CESC cis rs4728302 0.869 rs2042456 chr7:133580447 G/A cg10665199 chr7:133106180 EXOC4 0.4 5.47 0.32 1.03e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs9309473 1.000 rs7583255 chr2:73797996 T/G cg20560298 chr2:73613845 ALMS1 -0.53 -6.96 -0.39 2.6e-11 Metabolite levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05518842 chr16:1823291 MRPS34;EME2 -0.48 -6.5 -0.37 3.96e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11770686 0.967 rs4728289 chr7:75348505 C/T cg24179850 chr19:56154938 ZNF581 -0.41 -6.2 -0.36 2.14e-9 Essential tremor; CESC cis rs8141529 0.632 rs5762803 chr22:29193638 G/C cg15103426 chr22:29168792 CCDC117 0.69 9.43 0.5 2.09e-18 Lymphocyte counts; CESC cis rs2559856 0.935 rs2695287 chr12:102088361 T/C cg12213457 chr12:102090980 CHPT1 -0.36 -5.33 -0.31 2.07e-7 Blood protein levels; CESC cis rs10189230 0.967 rs10498113 chr2:222352629 C/T cg14652038 chr2:222343519 EPHA4 0.36 7.52 0.42 8.29e-13 Urate levels in lean individuals; CESC cis rs4595586 0.545 rs2388175 chr12:39389217 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.58 0.42 5.91e-13 Morning vs. evening chronotype; CESC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg11644478 chr21:40555479 PSMG1 1.03 17.63 0.73 1.46e-46 Cognitive function; CESC cis rs1538970 0.924 rs12097497 chr1:45880669 C/T cg05343316 chr1:45956843 TESK2 0.87 12.22 0.6 1.54e-27 Platelet count; CESC cis rs10256972 0.527 rs28671326 chr7:1174973 G/A cg07092213 chr7:1199455 ZFAND2A -0.42 -5.67 -0.33 3.74e-8 Longevity;Endometriosis; CESC cis rs668210 0.793 rs502363 chr11:65775592 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.65 7.02 0.4 1.82e-11 Cerebrospinal fluid biomarker levels; CESC cis rs11997175 0.545 rs4733457 chr8:33661236 G/A ch.8.33884649F chr8:33765107 NA 0.56 7.18 0.4 7.09e-12 Body mass index; CESC cis rs854765 0.583 rs8065970 chr17:17858771 A/G cg09796270 chr17:17721594 SREBF1 0.45 6.15 0.35 2.87e-9 Total body bone mineral density; CESC cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg18225595 chr11:63971243 STIP1 0.51 6.7 0.38 1.24e-10 Platelet count; CESC cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9457247 1.000 rs444988 chr6:167389674 A/T cg23791538 chr6:167370224 RNASET2 -0.58 -8.34 -0.46 4.24e-15 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14993712 chr7:138720786 ZC3HAV1L 0.58 6.52 0.37 3.47e-10 Gut microbiome composition (summer); CESC cis rs1707322 0.721 rs56255771 chr1:46224319 C/T cg06784218 chr1:46089804 CCDC17 0.4 7.33 0.41 2.85e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7618501 0.574 rs6765484 chr3:50041313 C/T cg21659725 chr3:3221576 CRBN -0.49 -6.87 -0.39 4.6e-11 Intelligence (multi-trait analysis); CESC trans rs9693444 0.898 rs4732697 chr8:29519861 A/G cg18287962 chr20:25176437 ENTPD6 -0.43 -6.2 -0.36 2.12e-9 Breast cancer; CESC cis rs7809950 1.000 rs2712215 chr7:107188207 A/G cg23024343 chr7:107201750 COG5 -0.42 -5.89 -0.34 1.15e-8 Coronary artery disease; CESC cis rs921968 0.565 rs7573999 chr2:219601392 A/G cg02176678 chr2:219576539 TTLL4 -0.47 -8.36 -0.46 3.68e-15 Mean corpuscular hemoglobin concentration; CESC cis rs7666738 0.761 rs1456210 chr4:98645932 T/G cg17366294 chr4:99064904 C4orf37 0.54 7.52 0.42 8.55e-13 Colonoscopy-negative controls vs population controls; CESC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.47 6.45 0.37 5.2400000000000005e-10 Menopause (age at onset); CESC cis rs7503807 0.688 rs901061 chr17:78595328 G/C cg09596252 chr17:78655493 RPTOR 0.37 5.21 0.3 3.84e-7 Obesity; CESC cis rs9815354 0.951 rs17063653 chr3:41863817 A/G cg03022575 chr3:42003672 ULK4 0.49 5.52 0.32 7.99e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs6594499 0.872 rs10050834 chr5:110427328 C/T cg04022379 chr5:110408740 TSLP 0.31 5.53 0.32 7.59e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg20573242 chr4:122745356 CCNA2 0.53 6.59 0.38 2.34e-10 Type 2 diabetes; CESC cis rs1153858 1.000 rs4534782 chr15:45652933 G/A cg21132104 chr15:45694354 SPATA5L1 0.85 11.64 0.58 1.47e-25 Homoarginine levels; CESC cis rs7116495 0.609 rs1548348 chr11:71750917 A/G cg10381502 chr11:71823885 C11orf51 -1.13 -6.89 -0.39 4.16e-11 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26040211 chr2:75186107 POLE4 0.6 6.59 0.38 2.33e-10 Gut microbiome composition (summer); CESC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg06074448 chr4:187884817 NA -0.38 -5.68 -0.33 3.49e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs2425143 1.000 rs73902914 chr20:34432882 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.67 5.78 0.33 2.11e-8 Blood protein levels; CESC cis rs6987853 0.686 rs55837592 chr8:42359974 T/C cg09913449 chr8:42400586 C8orf40 -0.38 -6.24 -0.36 1.72e-9 Mean corpuscular hemoglobin concentration; CESC cis rs2070488 0.804 rs13094715 chr3:38504430 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.83 13.43 0.64 1.05e-31 Electrocardiographic conduction measures; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09754948 chr16:28834200 ATXN2L 0.46 6.11 0.35 3.52e-9 Asthma; CESC trans rs875971 1.000 rs10257427 chr7:65743208 T/C cg26939375 chr7:64535504 NA -0.46 -6.08 -0.35 4.27e-9 Aortic root size; CESC cis rs28830936 0.966 rs890498 chr15:42111298 C/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.43 -5.94 -0.34 8.93e-9 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18425377 chr14:105167727 INF2 -0.55 -6.3 -0.36 1.26e-9 Gut microbiome composition (summer); CESC trans rs4756846 1.000 rs72871402 chr11:16472994 C/G cg05579622 chr5:10618622 ANKRD33B 0.71 6.21 0.36 2.01e-9 Obesity and osteoporosis; CESC cis rs11997175 0.766 rs4733176 chr8:33685334 A/T ch.8.33884649F chr8:33765107 NA 0.45 5.7 0.33 3.19e-8 Body mass index; CESC cis rs72781680 0.821 rs56064672 chr2:24156769 G/T cg08917208 chr2:24149416 ATAD2B 0.63 6.24 0.36 1.73e-9 Lymphocyte counts; CESC trans rs7615952 0.673 rs115942855 chr3:125601960 G/A cg07211511 chr3:129823064 LOC729375 -0.96 -8.16 -0.45 1.35e-14 Blood pressure (smoking interaction); CESC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg14196790 chr5:131705035 SLC22A5 0.32 5.06 0.3 7.67e-7 Breast cancer; CESC cis rs853679 0.607 rs35902873 chr6:28058949 G/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.83 5.09 0.3 6.76e-7 Depression; CESC cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg16006841 chr5:176797999 RGS14 -0.51 -5.82 -0.34 1.74e-8 Urinary electrolytes (magnesium/calcium ratio); CESC cis rs763121 0.853 rs7289855 chr22:39042221 G/T cg21395723 chr22:39101663 GTPBP1 0.45 5.56 0.32 6.69e-8 Menopause (age at onset); CESC cis rs7927771 0.524 rs10838771 chr11:47831332 A/G cg18512352 chr11:47633146 NA -0.36 -5.56 -0.32 6.67e-8 Subjective well-being; CESC cis rs7714584 1.000 rs34156253 chr5:150226230 A/G cg22134413 chr5:150180641 NA 0.53 5.6 0.33 5.4e-8 Crohn's disease; CESC trans rs11098499 0.954 rs12510138 chr4:120423935 C/G cg25214090 chr10:38739885 LOC399744 0.67 9.47 0.5 1.64e-18 Corneal astigmatism; CESC cis rs9443189 1.000 rs6906615 chr6:76489774 A/G cg01950844 chr6:76311363 SENP6 0.65 6.93 0.39 3.12e-11 Prostate cancer; CESC cis rs1707322 0.721 rs12045096 chr1:46114428 A/G cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg11764359 chr7:65958608 NA -0.95 -14.43 -0.66 3.25e-35 Aortic root size; CESC cis rs11958404 0.615 rs7711271 chr5:157452268 C/G cg05962755 chr5:157440814 NA 0.38 5.63 0.33 4.47e-8 IgG glycosylation; CESC cis rs73206853 0.563 rs57488849 chr12:111181785 C/T cg04375036 chr12:111181819 PPP1CC -0.64 -5.16 -0.3 4.82e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9303280 0.806 rs35736272 chr17:38032680 T/C cg20243544 chr17:37824526 PNMT 0.53 6.96 0.39 2.6e-11 Self-reported allergy; CESC cis rs11792861 0.851 rs4542004 chr9:111814478 A/G cg13535736 chr9:111863775 C9orf5 -0.45 -6.2 -0.36 2.14e-9 Menarche (age at onset); CESC cis rs738322 0.934 rs133016 chr22:38572582 C/T cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC cis rs4764487 0.735 rs11612258 chr12:6360683 G/T cg08284733 chr12:6341482 CD9 0.36 5.33 0.31 2.05e-7 Mean platelet volume; CESC cis rs7843479 0.601 rs4422769 chr8:21844265 A/G cg17168535 chr8:21777572 XPO7 0.73 11.71 0.58 8.3e-26 Mean corpuscular volume; CESC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -11.97 -0.59 1.09e-26 Alzheimer's disease; CESC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg20151795 chr6:28129481 ZNF389 0.4 5.23 0.31 3.51e-7 Parkinson's disease; CESC cis rs60154123 0.730 rs689248 chr1:210463122 A/G cg22029157 chr1:209979665 IRF6 -0.5 -6.24 -0.36 1.71e-9 Coronary artery disease; CESC cis rs11264213 0.579 rs72659681 chr1:36265565 G/A cg27506609 chr1:36549197 TEKT2 0.61 5.05 0.3 8.16e-7 Schizophrenia; CESC cis rs7116495 0.609 rs3750907 chr11:71822560 T/C cg26138937 chr11:71823887 C11orf51 1.36 8.4 0.46 2.8e-15 Severe influenza A (H1N1) infection; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16714605 chr19:10765132 ILF3;LOC147727 0.59 7.06 0.4 1.49e-11 Gut microbiome composition (summer); CESC cis rs35771425 0.509 rs3120782 chr1:211419700 A/T cg25617285 chr1:211431773 RCOR3 -0.38 -5.72 -0.33 2.85e-8 Educational attainment (years of education); CESC trans rs2727020 0.729 rs10839283 chr11:49490943 T/C cg15704280 chr7:45808275 SEPT13 0.83 11.46 0.58 5.59e-25 Coronary artery disease; CESC cis rs73001065 0.901 rs73004962 chr19:19713069 A/T cg03709012 chr19:19516395 GATAD2A 0.95 6.33 0.36 1.06e-9 LDL cholesterol; CESC cis rs1538970 0.781 rs34768551 chr1:46020408 G/A cg05343316 chr1:45956843 TESK2 0.85 10.86 0.55 5.75e-23 Platelet count; CESC cis rs447 1.000 rs7793598 chr7:83759108 C/T cg22846510 chr7:83753280 SEMA3A -0.44 -5.38 -0.31 1.64e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs7267979 0.545 rs6050426 chr20:25178265 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.52 7.64 0.42 4.06e-13 Liver enzyme levels (alkaline phosphatase); CESC cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg13175981 chr1:150552382 MCL1 0.62 9.22 0.49 9.44e-18 Tonsillectomy; CESC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg05025164 chr4:1340916 KIAA1530 0.5 6.9 0.39 3.71e-11 Longevity; CESC cis rs9796 0.621 rs28737302 chr15:41469943 G/A cg20272979 chr15:41787780 ITPKA 0.33 5.07 0.3 7.6e-7 Menopause (age at onset); CESC cis rs2845885 0.793 rs35927325 chr11:63882495 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.7 6.82 0.39 6.02e-11 Body mass index; CESC cis rs12410462 1.000 rs80168344 chr1:227655804 C/T cg23173402 chr1:227635558 NA 0.56 5.64 0.33 4.28e-8 Major depressive disorder; CESC cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg23711669 chr6:146136114 FBXO30 0.94 14.19 0.66 2.3e-34 Lobe attachment (rater-scored or self-reported); CESC cis rs1348850 0.793 rs6736390 chr2:178480314 T/C cg22681709 chr2:178499509 PDE11A -0.44 -6.49 -0.37 4.11e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7762018 0.891 rs7764839 chr6:170146351 C/A cg13891659 chr6:170190454 C6orf122;C6orf208 0.67 6.53 0.37 3.28e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 9.76 0.51 1.96e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs57221529 0.713 rs12521091 chr5:590710 G/T cg16447950 chr5:562315 NA -0.61 -6.47 -0.37 4.64e-10 Lung disease severity in cystic fibrosis; CESC cis rs6570726 0.905 rs375692 chr6:145840368 A/G cg23711669 chr6:146136114 FBXO30 0.76 11.32 0.57 1.74e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg21251018 chr6:28226885 NKAPL -0.37 -5.41 -0.32 1.41e-7 Depression; CESC cis rs870825 0.655 rs28451943 chr4:185645572 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs11190604 0.725 rs9420796 chr10:102323092 G/C cg07080220 chr10:102295463 HIF1AN 0.56 5.29 0.31 2.52e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs2050392 0.762 rs306587 chr10:30722908 G/C cg25182066 chr10:30743637 MAP3K8 -0.43 -5.81 -0.34 1.82e-8 Inflammatory bowel disease; CESC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg00129232 chr17:37814104 STARD3 -0.57 -7.57 -0.42 6.31e-13 Glomerular filtration rate (creatinine); CESC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.23 -0.36 1.79e-9 Menopause (age at onset); CESC cis rs9910055 0.593 rs58392387 chr17:42297889 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.42 5.06 0.3 7.72e-7 Total body bone mineral density; CESC cis rs7927771 0.832 rs10838697 chr11:47384484 T/A cg18512352 chr11:47633146 NA -0.53 -7.46 -0.42 1.22e-12 Subjective well-being; CESC cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg23711669 chr6:146136114 FBXO30 0.91 11.75 0.59 5.92e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs360798 0.532 rs1553832 chr2:63013515 C/G cg17519650 chr2:63277830 OTX1 -0.56 -7.39 -0.41 1.96e-12 Coronary artery disease; CESC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg08888203 chr3:10149979 C3orf24 0.44 5.57 0.32 6.29e-8 Alzheimer's disease; CESC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg12963246 chr6:28129442 ZNF389 0.56 7.63 0.42 4.26e-13 Depression; CESC trans rs11098499 0.865 rs9994730 chr4:120381564 A/C cg25214090 chr10:38739885 LOC399744 0.71 9.82 0.52 1.33e-19 Corneal astigmatism; CESC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg17949981 chr6:28129498 ZNF389 0.42 5.24 0.31 3.27e-7 Depression; CESC cis rs10504229 0.679 rs72649132 chr8:58054615 G/A cg22535103 chr8:58192502 C8orf71 -0.77 -8.08 -0.44 2.33e-14 Developmental language disorder (linguistic errors); CESC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg11764359 chr7:65958608 NA -0.7 -9.25 -0.49 7.82e-18 Aortic root size; CESC cis rs9291683 0.546 rs13120348 chr4:10053155 C/G cg02734326 chr4:10020555 SLC2A9 -0.43 -6.25 -0.36 1.61e-9 Bone mineral density; CESC cis rs9309473 0.898 rs9807961 chr2:73694043 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -6.77 -0.38 8.09e-11 Metabolite levels; CESC cis rs28673728 0.868 rs28380108 chr1:38409103 G/C cg18451016 chr1:38461880 NA 0.4 5.92 0.34 9.92e-9 Red cell distribution width; CESC trans rs17764205 0.777 rs10424519 chr19:3253532 C/G cg27384338 chr17:2031545 SMG6 0.76 6.24 0.36 1.7e-9 Bipolar disorder and schizophrenia; CESC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg11644478 chr21:40555479 PSMG1 1.02 16.31 0.71 7.16e-42 Cognitive function; CESC cis rs2228479 0.850 rs17226973 chr16:89825248 T/C cg04013166 chr16:89971882 TCF25 0.79 6.75 0.38 9.14e-11 Skin colour saturation; CESC cis rs10751667 0.666 rs10902241 chr11:949129 G/A cg20946044 chr11:1010712 AP2A2 -0.38 -5.24 -0.31 3.23e-7 Alzheimer's disease (late onset); CESC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg20151795 chr6:28129481 ZNF389 0.4 5.39 0.31 1.58e-7 Depression; CESC cis rs447735 0.587 rs11647958 chr16:89720909 A/T cg03605463 chr16:89740564 NA 0.4 5.1 0.3 6.55e-7 Hemoglobin concentration; CESC cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg17279839 chr7:150038598 RARRES2 0.43 5.32 0.31 2.18e-7 Blood protein levels;Circulating chemerin levels; CESC trans rs875971 0.660 rs3857686 chr7:66036191 C/T cg26939375 chr7:64535504 NA -0.64 -8.8 -0.48 1.77e-16 Aortic root size; CESC cis rs733175 0.855 rs9291640 chr4:10007086 C/T cg11266682 chr4:10021025 SLC2A9 0.37 5.04 0.3 8.82e-7 Psychosis and Alzheimer's disease; CESC cis rs1865721 0.761 rs7242709 chr18:73222819 T/C cg26385618 chr18:73139727 C18orf62 -0.53 -7.75 -0.43 2.02e-13 Intelligence; CESC cis rs9581857 0.547 rs75800999 chr13:28055293 A/G cg01674679 chr13:27998804 GTF3A -0.65 -5.19 -0.3 4.24e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs501120 0.810 rs683297 chr10:44746140 A/G cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.17e-11 Coronary artery disease;Coronary heart disease; CESC cis rs631288 0.557 rs7546434 chr1:146676339 A/G cg25205988 chr1:146714368 CHD1L 1.05 6.69 0.38 1.28e-10 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs477692 0.544 rs7923750 chr10:131446895 G/C cg05714579 chr10:131428358 MGMT -0.71 -9.8 -0.52 1.48e-19 Response to temozolomide; CESC cis rs7202877 0.561 rs2865532 chr16:75350975 A/G cg04384234 chr16:75411784 CFDP1 -0.48 -5.7 -0.33 3.12e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs7726839 0.540 rs61580655 chr5:597564 A/G cg16447950 chr5:562315 NA -0.59 -6.01 -0.35 6.18e-9 Obesity-related traits; CESC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg17724175 chr1:150552817 MCL1 0.4 6.28 0.36 1.4e-9 Melanoma; CESC cis rs2243480 1.000 rs316327 chr7:65609201 G/T cg12463550 chr7:65579703 CRCP -0.79 -6.28 -0.36 1.38e-9 Diabetic kidney disease; CESC cis rs2273669 0.667 rs12196143 chr6:109302372 C/T cg05315195 chr6:109294784 ARMC2 -0.65 -6.08 -0.35 4.15e-9 Prostate cancer; CESC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg10596483 chr8:143751796 JRK -0.46 -5.05 -0.3 8.37e-7 Urinary tract infection frequency; CESC cis rs7508 0.694 rs2073572 chr8:17921666 C/T cg18067069 chr8:17937731 ASAH1 -0.39 -5.19 -0.3 4.21e-7 Atrial fibrillation; CESC cis rs7246657 0.882 rs59224125 chr19:37963205 T/C cg23950597 chr19:37808831 NA -0.55 -5.99 -0.35 6.69e-9 Coronary artery calcification; CESC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg03709012 chr19:19516395 GATAD2A -0.96 -14.11 -0.66 4.09e-34 Tonsillectomy; CESC cis rs1620921 0.505 rs1965092 chr6:161204889 C/T cg01280913 chr6:161186852 NA -0.36 -5.27 -0.31 2.81e-7 Lipoprotein (a) - cholesterol levels; CESC cis rs1538970 0.884 rs1771551 chr1:45883643 C/G cg05343316 chr1:45956843 TESK2 0.82 12.03 0.59 6.96e-27 Platelet count; CESC cis rs4523957 0.928 rs9899193 chr17:2156917 G/A cg16513277 chr17:2031491 SMG6 0.6 8.27 0.45 6.71e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs72772090 0.634 rs72773912 chr5:96107801 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -5.7 -0.33 3.24e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg00149659 chr3:10157352 C3orf10 0.73 8.54 0.46 1.05e-15 Alzheimer's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12551462 chr6:153304904 FBXO5 0.61 6.95 0.39 2.75e-11 Gut microbiome composition (summer); CESC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg27286337 chr10:134555280 INPP5A 0.69 8.1 0.45 2.01e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2832191 0.720 rs2832200 chr21:30499165 G/A cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.5e-20 Dental caries; CESC cis rs16857609 0.529 rs74723351 chr2:218288217 G/A cg15335768 chr2:218268053 DIRC3 -0.37 -5.25 -0.31 3.15e-7 Breast cancer;Breast cancer (estrogen-receptor negative); CESC cis rs6430585 0.527 rs57530667 chr2:136444338 A/G cg07169764 chr2:136633963 MCM6 1.09 12.56 0.61 1.07e-28 Corneal structure; CESC cis rs9976767 0.608 rs3746923 chr21:43826344 C/T cg23042151 chr21:43824109 UBASH3A -0.33 -6.06 -0.35 4.61e-9 Type 1 diabetes; CESC cis rs6121246 0.909 rs6058450 chr20:30343911 G/A cg13852791 chr20:30311386 BCL2L1 0.81 8.61 0.47 6.48e-16 Mean corpuscular hemoglobin; CESC cis rs9457247 0.579 rs2181059 chr6:167441624 T/C cg23791538 chr6:167370224 RNASET2 -0.57 -7.7 -0.43 2.7e-13 Crohn's disease; CESC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg04369109 chr6:150039330 LATS1 -0.38 -5.29 -0.31 2.58e-7 Lung cancer; CESC cis rs9611565 0.559 rs132761 chr22:42004371 C/T cg03806693 chr22:41940476 POLR3H 1.09 12.94 0.62 5.17e-30 Vitiligo; CESC cis rs11690935 0.851 rs10930502 chr2:172890588 A/G cg13550731 chr2:172543902 DYNC1I2 -0.66 -8.9 -0.48 9.29e-17 Schizophrenia; CESC cis rs10779751 0.879 rs7543400 chr1:11283964 C/G cg08854313 chr1:11322531 MTOR 0.91 14.25 0.66 1.34e-34 Body mass index; CESC cis rs208520 0.690 rs207102 chr6:66795671 G/A cg07460842 chr6:66804631 NA -1.0 -13.33 -0.63 2.21e-31 Exhaled nitric oxide output; CESC cis rs9814567 1.000 rs1498718 chr3:134205920 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.76 -0.33 2.32e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1707322 0.752 rs28623463 chr1:46170758 A/C cg06784218 chr1:46089804 CCDC17 0.41 7.21 0.41 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs818427 0.896 rs460832 chr5:112225148 G/A cg07820702 chr5:112228657 REEP5 -0.43 -5.36 -0.31 1.85e-7 Total body bone mineral density; CESC cis rs2290720 1.000 rs2290720 chr12:101687043 C/T cg22051763 chr12:101673672 UTP20 -0.43 -5.24 -0.31 3.24e-7 Brain structure (hippocampal volume); CESC cis rs2066819 1.000 rs78149779 chr12:56694817 A/G cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg25517755 chr10:38738941 LOC399744 -0.43 -5.64 -0.33 4.44e-8 Extrinsic epigenetic age acceleration; CESC cis rs727563 0.552 rs4822045 chr22:41985958 C/A cg03806693 chr22:41940476 POLR3H -1.16 -13.06 -0.63 1.99e-30 Crohn's disease;Inflammatory bowel disease; CESC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg03609598 chr5:56110824 MAP3K1 -0.55 -5.92 -0.34 9.88e-9 Initial pursuit acceleration; CESC cis rs3791406 0.654 rs747787 chr2:240032319 G/A cg13090969 chr2:240043331 HDAC4 -0.51 -6.01 -0.35 6.06e-9 Skin aging (microtopography measurement); CESC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg22800045 chr5:56110881 MAP3K1 0.8 9.57 0.51 8.15e-19 Initial pursuit acceleration; CESC cis rs9430161 0.579 rs7542354 chr1:11040385 G/A cg27631724 chr1:11040367 C1orf127 0.44 7.63 0.42 4.18e-13 Ewing sarcoma; CESC cis rs863345 0.604 rs11265008 chr1:158498671 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs17401966 1.000 rs4846208 chr1:10313839 T/C cg15208524 chr1:10270712 KIF1B 0.5 6.47 0.37 4.65e-10 Hepatocellular carcinoma; CESC cis rs950027 0.549 rs2899375 chr15:45598335 G/A cg21132104 chr15:45694354 SPATA5L1 -0.58 -6.96 -0.39 2.74e-11 Response to fenofibrate (adiponectin levels); CESC cis rs8114671 0.562 rs6120763 chr20:33506400 C/G cg24642439 chr20:33292090 TP53INP2 0.44 5.32 0.31 2.18e-7 Height; CESC cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg18180107 chr4:99064573 C4orf37 0.43 5.39 0.31 1.55e-7 Colonoscopy-negative controls vs population controls; CESC cis rs16870629 0.564 rs326050 chr5:1002620 C/T cg00278107 chr5:1061253 SLC12A7 0.7 11.17 0.57 5.29e-24 QT interval; CESC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.79 0.39 7.29e-11 Bipolar disorder; CESC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 0.67 9.21 0.49 1e-17 Age at first birth; CESC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg04944784 chr2:26401820 FAM59B -0.67 -7.75 -0.43 2e-13 Gut microbiome composition (summer); CESC cis rs2243480 0.901 rs3813708 chr7:65305632 C/A cg18252515 chr7:66147081 NA -1.22 -11.91 -0.59 1.82e-26 Diabetic kidney disease; CESC cis rs9611565 0.649 rs202625 chr22:41827082 G/A cg06481639 chr22:41940642 POLR3H 0.63 6.29 0.36 1.27e-9 Vitiligo; CESC cis rs7590720 1.000 rs7590720 chr2:216898658 A/G cg12620499 chr2:216877984 MREG -0.9 -12.71 -0.62 3.24e-29 Alcohol dependence; CESC cis rs7020830 0.898 rs2047010 chr9:37077947 A/G cg14294708 chr9:37120828 ZCCHC7 1.28 24.7 0.84 1.03e-70 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20881074 chr2:45236659 SIX2 0.58 6.71 0.38 1.2e-10 Gut microbiome composition (summer); CESC cis rs3820068 0.581 rs61056912 chr1:15926296 A/G cg16988262 chr1:15930761 NA 0.33 5.35 0.31 1.89e-7 Systolic blood pressure; CESC cis rs7927592 0.956 rs7113287 chr11:68372186 A/T cg01657329 chr11:68192670 LRP5 -0.39 -5.1 -0.3 6.44e-7 Total body bone mineral density; CESC cis rs2228479 0.850 rs11639925 chr16:89908250 C/T cg06558623 chr16:89946397 TCF25 1.12 8.25 0.45 7.72e-15 Skin colour saturation; CESC cis rs10779751 0.734 rs2486920 chr1:11125050 T/C cg08854313 chr1:11322531 MTOR 0.77 10.41 0.54 1.73e-21 Body mass index; CESC cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg16339924 chr4:17578868 LAP3 0.59 7.41 0.41 1.69e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07564188 chr1:165667906 ALDH9A1 0.61 7.31 0.41 3.2e-12 Gut microbiome composition (summer); CESC cis rs7089973 0.604 rs11819372 chr10:116594934 A/G cg23260525 chr10:116636907 FAM160B1 0.4 7.74 0.43 2.1e-13 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg05863683 chr7:1912471 MAD1L1 0.39 6.0 0.35 6.48e-9 Bipolar disorder and schizophrenia; CESC cis rs933688 0.556 rs4916855 chr5:90596345 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.56 -7.12 -0.4 1e-11 Smoking behavior; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12694510 chr17:26646013 TMEM97 -0.52 -6.87 -0.39 4.64e-11 Fibrinogen levels; CESC trans rs801193 0.901 rs4273746 chr7:66301111 C/T cg26939375 chr7:64535504 NA -0.66 -8.37 -0.46 3.27e-15 Aortic root size; CESC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg07507251 chr3:52567010 NT5DC2 0.34 5.47 0.32 1.04e-7 Bipolar disorder; CESC cis rs728616 0.558 rs2343302 chr10:82163186 A/G cg05935833 chr10:81318306 SFTPA2 -0.46 -5.71 -0.33 3.09e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9611565 0.649 rs5758442 chr22:42133060 T/C cg06634786 chr22:41940651 POLR3H 0.49 5.5 0.32 8.83e-8 Vitiligo; CESC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs2243480 0.901 rs13237344 chr7:66022256 T/A cg12463550 chr7:65579703 CRCP 0.71 5.54 0.32 7.17e-8 Diabetic kidney disease; CESC cis rs55665837 0.524 rs2882128 chr11:14414634 A/C cg19336497 chr11:14380999 RRAS2 -0.36 -5.33 -0.31 2.12e-7 Vitamin D levels; CESC cis rs4604732 0.631 rs34924545 chr1:247626892 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.45 0.32 1.17e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs703842 0.616 rs7489290 chr12:58228588 C/G cg04478727 chr12:58166393 METTL1;FAM119B 0.59 6.86 0.39 4.78e-11 Multiple sclerosis; CESC cis rs6691722 0.503 rs2274167 chr1:24707296 C/T cg18323236 chr1:24743029 NIPAL3 0.37 5.47 0.32 1.02e-7 Response to interferon beta in multiple sclerosis; CESC cis rs453301 0.682 rs2929451 chr8:9085295 A/T cg17143192 chr8:8559678 CLDN23 0.4 5.07 0.3 7.6e-7 Joint mobility (Beighton score); CESC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg04944784 chr2:26401820 FAM59B -0.67 -7.75 -0.43 2e-13 Gut microbiome composition (summer); CESC cis rs4948102 0.731 rs4948099 chr7:56072250 A/C cg09872392 chr7:56161020 PHKG1 0.41 6.48 0.37 4.44e-10 Plasma homocysteine levels (post-methionine load test); CESC cis rs3768617 0.510 rs10797838 chr1:183077020 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 14.19 0.66 2.14e-34 Fuchs's corneal dystrophy; CESC cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg25019033 chr10:957182 NA -0.65 -7.92 -0.44 6.62e-14 Eosinophil percentage of granulocytes; CESC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg00149659 chr3:10157352 C3orf10 0.69 8.12 0.45 1.77e-14 Alzheimer's disease; CESC trans rs9937837 0.959 rs9925985 chr16:31305593 A/C cg04903759 chr3:167238645 WDR49 0.53 6.6 0.38 2.21e-10 Systemic lupus erythematosus; CESC cis rs6942756 0.713 rs691158 chr7:129129982 G/T cg02491457 chr7:128862824 NA -0.57 -7.81 -0.43 1.32e-13 White matter hyperintensity burden; CESC cis rs798766 1.000 rs1665362 chr4:1726367 T/A cg05874882 chr4:1763078 NA -0.61 -8.63 -0.47 5.74e-16 Bladder cancer;Urinary bladder cancer; CESC cis rs826838 0.510 rs17523988 chr12:39222785 A/C cg13010199 chr12:38710504 ALG10B 0.58 7.73 0.43 2.17e-13 Heart rate; CESC cis rs12136530 0.774 rs12409301 chr1:19774715 G/A cg01832549 chr1:19774989 CAPZB -0.47 -6.84 -0.39 5.52e-11 Lead levels in blood; CESC cis rs962856 0.964 rs1486135 chr2:67596265 T/C cg09028215 chr2:67624308 ETAA1 -0.41 -5.43 -0.32 1.25e-7 Pancreatic cancer; CESC cis rs7589342 0.895 rs2033008 chr2:106502585 T/A cg16077055 chr2:106428750 NCK2 0.41 5.85 0.34 1.46e-8 Addiction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16517634 chr2:8977876 KIDINS220 0.53 6.12 0.35 3.31e-9 Gut microbiome composition (summer); CESC cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg05347473 chr6:146136440 FBXO30 0.71 8.87 0.48 1.14e-16 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg03467027 chr4:99064603 C4orf37 0.49 6.18 0.35 2.44e-9 Colonoscopy-negative controls vs population controls; CESC cis rs6502050 0.805 rs62080003 chr17:80078957 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.16 0.3 4.82e-7 Life satisfaction; CESC cis rs1580019 0.961 rs1580022 chr7:32497712 C/A cg06627557 chr7:32535165 LSM5;AVL9 0.73 10.13 0.53 1.34e-20 Cognitive ability; CESC cis rs12927205 0.510 rs7185601 chr16:72035082 A/G cg14768367 chr16:72042858 DHODH 0.71 5.87 0.34 1.28e-8 Cholesterol, total;LDL cholesterol; CESC cis rs5758659 0.967 rs5751250 chr22:42639645 T/G cg04733989 chr22:42467013 NAGA 0.42 5.78 0.33 2.14e-8 Cognitive function; CESC cis rs4835473 0.897 rs3874 chr4:144889948 A/G cg25736465 chr4:144833511 NA 0.41 6.26 0.36 1.55e-9 Immature fraction of reticulocytes; CESC cis rs727505 0.866 rs3214004 chr7:124720929 T/C cg23710748 chr7:124431027 NA -0.4 -6.52 -0.37 3.56e-10 Lewy body disease; CESC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.76 0.47 2.33e-16 Bipolar disorder; CESC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs8027181 0.839 rs10459647 chr15:73035241 T/C cg25632853 chr15:73088954 NA 0.31 5.52 0.32 8.02e-8 Triglyceride levels; CESC cis rs2732480 0.577 rs2732486 chr12:48737834 G/A cg04545296 chr12:48745243 ZNF641 0.44 7.23 0.41 5.12e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs718433 0.556 rs1569287 chr14:22215593 C/T cg02257791 chr14:22217085 NA -0.32 -5.08 -0.3 7.19e-7 Intraocular pressure; CESC cis rs5769765 1.000 rs910800 chr22:50278642 C/T cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC trans rs9467711 0.606 rs9379875 chr6:26444732 C/T cg06606381 chr12:133084897 FBRSL1 -0.82 -6.76 -0.38 9.01e-11 Autism spectrum disorder or schizophrenia; CESC cis rs7103648 0.966 rs1377416 chr11:47416746 C/T cg20307385 chr11:47447363 PSMC3 0.96 16.51 0.71 1.41e-42 Diastolic blood pressure;Systolic blood pressure; CESC cis rs6951245 0.882 rs11764817 chr7:1064610 T/C cg03188948 chr7:1209495 NA 0.56 5.73 0.33 2.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg11890956 chr21:40555474 PSMG1 -0.62 -8.45 -0.46 1.95e-15 Menarche (age at onset); CESC cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg23463467 chr20:60627584 TAF4 0.35 5.06 0.3 7.96e-7 Body mass index; CESC cis rs868036 0.958 rs3784709 chr15:68072275 C/T cg08079166 chr15:68083412 MAP2K5 0.39 5.89 0.34 1.16e-8 Restless legs syndrome; CESC cis rs6032067 0.929 rs45461302 chr20:43805274 G/A cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.5e-8 Blood protein levels; CESC cis rs7927771 0.524 rs7111576 chr11:47787445 G/A cg20307385 chr11:47447363 PSMC3 0.61 8.59 0.47 7.41e-16 Subjective well-being; CESC cis rs4588572 0.537 rs7719228 chr5:77730576 G/A cg11547950 chr5:77652471 NA -0.39 -5.31 -0.31 2.36e-7 Triglycerides; CESC cis rs2204008 0.774 rs11495520 chr12:38060605 T/G cg26384229 chr12:38710491 ALG10B 0.74 10.7 0.55 1.96e-22 Bladder cancer; CESC cis rs6484504 0.576 rs208067 chr11:31153578 C/T cg14844989 chr11:31128820 NA -0.41 -5.67 -0.33 3.71e-8 Red blood cell count; CESC cis rs10129255 0.912 rs8011090 chr14:107134913 G/A cg23076370 chr14:107095027 NA -0.41 -5.16 -0.3 4.85e-7 Kawasaki disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11737246 chr15:40401244 BMF 0.56 6.27 0.36 1.49e-9 Gut microbiome composition (summer); CESC cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg00149659 chr3:10157352 C3orf10 0.99 12.05 0.59 6.02e-27 Alzheimer's disease; CESC cis rs919433 0.783 rs2565165 chr2:198233575 T/G cg20885578 chr2:198174922 NA 0.41 5.36 0.31 1.79e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs858239 0.600 rs7787110 chr7:23138474 C/T cg23682824 chr7:23144976 KLHL7 0.54 7.82 0.43 1.23e-13 Cerebrospinal fluid biomarker levels; CESC cis rs1797885 0.564 rs2454422 chr3:12603900 C/T cg26432171 chr3:12704882 RAF1 -0.5 -6.65 -0.38 1.69e-10 Immature fraction of reticulocytes; CESC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg21963583 chr11:68658836 MRPL21 0.39 5.51 0.32 8.33e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7914558 1.000 rs7071373 chr10:104771922 A/G cg08650961 chr10:104748594 CNNM2 0.33 5.52 0.32 8.25e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12347191 0.500 rs925485 chr9:100619561 G/C cg13688889 chr9:100608707 NA -0.91 -13.42 -0.64 1.07e-31 Orofacial clefts; CESC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg10541313 chr22:46663664 TTC38 0.67 5.9 0.34 1.1e-8 LDL cholesterol;Cholesterol, total; CESC cis rs901683 1.000 rs34285816 chr10:45976851 G/A cg16031567 chr10:46195673 NA -0.76 -5.09 -0.3 6.84e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs11229555 1.000 rs11603890 chr11:58402251 T/C cg15696309 chr11:58395628 NA -0.44 -5.72 -0.33 2.82e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs9768139 0.935 rs6953748 chr7:158121184 G/A cg24154853 chr7:158122151 PTPRN2 -0.37 -5.86 -0.34 1.4e-8 Calcium levels; CESC cis rs6449957 0.607 rs251394 chr5:67512000 C/G cg23036683 chr5:67512108 NA 0.44 6.07 0.35 4.36e-9 Cleft lip with or without cleft palate; CESC cis rs17021463 0.673 rs12507134 chr4:95283980 C/A cg11021082 chr4:95130006 SMARCAD1 0.51 6.97 0.39 2.55e-11 Testicular germ cell tumor; CESC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -12.3 -0.6 7.95e-28 Alzheimer's disease; CESC cis rs798766 1.000 rs11729657 chr4:1737585 T/C cg07041428 chr4:1763019 NA -0.4 -5.7 -0.33 3.11e-8 Bladder cancer;Urinary bladder cancer; CESC cis rs769267 0.864 rs7245983 chr19:19657632 A/C cg02546618 chr19:19431379 KIAA0892;SF4 0.42 5.11 0.3 6.28e-7 Tonsillectomy; CESC cis rs2228479 0.618 rs62052174 chr16:89950901 G/A cg14709524 chr16:89940631 TCF25 0.74 5.75 0.33 2.43e-8 Skin colour saturation; CESC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg14196790 chr5:131705035 SLC22A5 -0.34 -5.59 -0.32 5.6e-8 Breast cancer; CESC cis rs763121 0.853 rs7289855 chr22:39042221 G/T cg06544989 chr22:39130855 UNC84B 0.51 8.67 0.47 4.48e-16 Menopause (age at onset); CESC cis rs7264396 0.580 rs2425173 chr20:34445142 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.67 6.74 0.38 1.01e-10 Total cholesterol levels; CESC cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg24818145 chr4:99064322 C4orf37 0.41 5.23 0.31 3.37e-7 Colonoscopy-negative controls vs population controls; CESC trans rs7715474 0.738 rs10059100 chr5:120100784 A/G cg12384126 chr1:185285600 IVNS1ABP -0.46 -6.02 -0.35 5.66e-9 Post bronchodilator FEV1/FVC ratio; CESC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg09658497 chr7:2847517 GNA12 -0.43 -6.12 -0.35 3.43e-9 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08926035 chr11:64521052 PYGM 0.42 6.1 0.35 3.65e-9 Fibrinogen levels; CESC cis rs7937682 0.883 rs659529 chr11:111436896 T/A cg22437258 chr11:111473054 SIK2 0.74 9.62 0.51 5.34e-19 Primary sclerosing cholangitis; CESC cis rs1707322 1.000 rs785490 chr1:46577124 T/C cg03146154 chr1:46216737 IPP -0.74 -9.64 -0.51 4.75e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg18301423 chr5:131593218 PDLIM4 0.37 5.36 0.31 1.78e-7 Breast cancer; CESC cis rs10256972 0.527 rs2949170 chr7:1216438 A/G cg27094323 chr7:1216898 NA -0.45 -6.05 -0.35 4.86e-9 Longevity;Endometriosis; CESC cis rs7927771 0.524 rs4752798 chr11:47886364 T/C cg20307385 chr11:47447363 PSMC3 -0.58 -8.11 -0.45 1.89e-14 Subjective well-being; CESC cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg05340658 chr4:99064831 C4orf37 0.76 11.26 0.57 2.63e-24 Colonoscopy-negative controls vs population controls; CESC cis rs12701220 0.689 rs12530960 chr7:1095471 G/A cg26769984 chr7:1090371 C7orf50 0.58 5.99 0.35 6.9e-9 Bronchopulmonary dysplasia; CESC cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg03433033 chr1:76189801 ACADM 0.68 8.35 0.46 3.96e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs55788414 0.932 rs2317123 chr16:81182636 A/T cg06400318 chr16:81190750 PKD1L2 -0.59 -6.8 -0.39 6.75e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs2531992 0.686 rs933392 chr16:4032716 T/G cg05927578 chr16:4029543 ADCY9 0.54 6.86 0.39 4.82e-11 Waist circumference; CESC cis rs703842 1.000 rs11172349 chr12:58212528 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.71 9.01 0.48 4.25e-17 Multiple sclerosis; CESC cis rs12900413 0.631 rs62023455 chr15:90301999 G/A cg24249390 chr15:90295951 MESP1 -0.4 -5.36 -0.31 1.79e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs523522 0.673 rs643372 chr12:121022640 C/G cg12219531 chr12:120966889 COQ5 0.76 10.07 0.53 2.15e-20 High light scatter reticulocyte count; CESC cis rs12142240 0.698 rs17357628 chr1:46808462 A/G cg00530320 chr1:46809349 NSUN4 0.6 7.98 0.44 4.48e-14 Menopause (age at onset); CESC cis rs2279817 1.000 rs1339800 chr1:18020201 C/G cg21791023 chr1:18019539 ARHGEF10L -0.58 -8.52 -0.46 1.25e-15 Neuroticism; CESC cis rs734999 0.588 rs3001837 chr1:2532506 G/A cg20673091 chr1:2541236 MMEL1 -0.45 -7.46 -0.42 1.2e-12 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13997647 chr14:95623841 FLJ45244;DICER1 0.6 6.87 0.39 4.49e-11 Gut microbiome composition (summer); CESC cis rs6121246 0.697 rs6120970 chr20:30232452 C/T cg13852791 chr20:30311386 BCL2L1 0.67 7.01 0.4 1.94e-11 Mean corpuscular hemoglobin; CESC cis rs79387448 0.655 rs3771167 chr2:102986188 A/G cg09003973 chr2:102972529 NA 1.22 10.27 0.53 4.91e-21 Gut microbiota (bacterial taxa); CESC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg04673462 chr1:38461896 NA -0.37 -5.08 -0.3 7.09e-7 Coronary artery disease; CESC cis rs1005277 0.505 rs200939 chr10:38139483 T/C cg25427524 chr10:38739819 LOC399744 -0.68 -10.03 -0.52 2.86e-20 Extrinsic epigenetic age acceleration; CESC cis rs1568889 0.838 rs10835299 chr11:28277693 A/G cg06544937 chr11:28130018 METT5D1;KIF18A -0.81 -13.99 -0.65 1.14e-33 Bipolar disorder; CESC cis rs3857536 0.740 rs9354391 chr6:66890183 C/T cg07460842 chr6:66804631 NA 0.41 5.34 0.31 1.96e-7 Blood trace element (Cu levels); CESC cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.26e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.863 rs3822195 chr4:120471660 C/T cg24375607 chr4:120327624 NA 0.45 5.5 0.32 9.09e-8 Corneal astigmatism; CESC cis rs763121 0.853 rs138709 chr22:39139216 C/G cg06022373 chr22:39101656 GTPBP1 0.91 16.86 0.72 7.73e-44 Menopause (age at onset); CESC cis rs9486715 0.830 rs2255552 chr6:96999643 A/G cg06623918 chr6:96969491 KIAA0776 -0.88 -13.31 -0.63 2.73e-31 Headache; CESC trans rs561341 0.769 rs12941700 chr17:30185022 A/G cg20587970 chr11:113659929 NA 0.99 11.03 0.56 1.56e-23 Hip circumference adjusted for BMI; CESC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg22307029 chr19:49891270 CCDC155 0.7 8.38 0.46 3.2e-15 Multiple sclerosis; CESC cis rs7193541 0.684 rs8062783 chr16:74691264 C/T cg05580060 chr16:74700937 RFWD3 0.47 5.96 0.34 8.02e-9 Multiple myeloma; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24243429 chr4:148653539 ARHGAP10 -0.44 -6.4 -0.37 7.11e-10 Gambling; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15620385 chr12:26986279 ITPR2 -0.45 -6.17 -0.35 2.5e-9 Fibrinogen levels; CESC cis rs9790314 1.000 rs2218803 chr3:161047973 T/G cg04691961 chr3:161091175 C3orf57 -0.41 -5.22 -0.31 3.57e-7 Morning vs. evening chronotype; CESC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg11764359 chr7:65958608 NA 0.66 8.61 0.47 6.69e-16 Aortic root size; CESC cis rs75064307 0.834 rs4855561 chr3:108116331 T/C cg03329597 chr3:108125523 MYH15 0.5 5.61 0.33 5.18e-8 Intelligence (multi-trait analysis); CESC cis rs9625935 0.518 rs9625870 chr22:30261219 C/T cg01021169 chr22:30184971 ASCC2 -0.41 -6.35 -0.36 9.43e-10 Tonsillectomy; CESC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg19901468 chr14:105411992 AHNAK2 -0.6 -8.79 -0.48 1.91e-16 Rheumatoid arthritis; CESC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -13.59 -0.64 2.71e-32 Alzheimer's disease; CESC cis rs1843834 0.539 rs2047135 chr2:225427302 G/C cg12698349 chr2:225449008 CUL3 0.63 8.96 0.48 6.05e-17 IgE levels in asthmatics (D.p. specific); CESC trans rs875971 1.000 rs9986696 chr7:65704576 C/A cg26939375 chr7:64535504 NA -0.46 -6.16 -0.35 2.64e-9 Aortic root size; CESC cis rs17209837 1.000 rs45546132 chr7:87086140 C/T cg00919237 chr7:87102261 ABCB4 -0.49 -5.77 -0.33 2.23e-8 Gallbladder cancer; CESC cis rs4148883 0.689 rs1869458 chr4:100024728 C/G cg13256891 chr4:100009986 ADH5 0.52 6.98 0.39 2.38e-11 Alcohol dependence; CESC cis rs2760061 0.598 rs673726 chr1:228120173 T/C cg01973587 chr1:228161476 NA 0.38 5.93 0.34 9.18e-9 Diastolic blood pressure; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg20930514 chr14:77499758 NA -0.43 -6.01 -0.35 6.26e-9 Height; CESC cis rs8005677 0.828 rs12589539 chr14:23396680 A/G cg01529538 chr14:23388837 RBM23 0.45 6.13 0.35 3.22e-9 Cognitive ability (multi-trait analysis); CESC cis rs4315565 0.541 rs7580085 chr2:69282900 C/A cg12800200 chr2:69260302 ANTXR1 -0.38 -5.33 -0.31 2.09e-7 Height; CESC cis rs7072216 0.690 rs113195335 chr10:100175532 A/C cg26618903 chr10:100175079 PYROXD2 -0.38 -5.96 -0.34 8.02e-9 Metabolite levels; CESC cis rs4460629 0.905 rs4971077 chr1:155128717 T/C cg02153340 chr1:155202674 NA -0.37 -5.5 -0.32 8.76e-8 Serum magnesium levels; CESC cis rs644799 1.000 rs516551 chr11:95588626 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.55 0.46 1.01e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs796364 0.806 rs6743396 chr2:200860138 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.85 7.68 0.43 3.06e-13 Schizophrenia; CESC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg08061076 chr7:1943177 MAD1L1 -0.38 -5.09 -0.3 6.68e-7 Bipolar disorder and schizophrenia; CESC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg14664628 chr15:75095509 CSK -0.52 -7.03 -0.4 1.77e-11 Breast cancer; CESC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 11.36 0.57 1.28e-24 Platelet count; CESC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg08392591 chr16:89556376 ANKRD11 0.59 8.1 0.45 2e-14 Multiple myeloma (IgH translocation); CESC cis rs1178968 0.748 rs10248063 chr7:72776008 T/G cg25889504 chr7:72793014 NA 0.47 5.03 0.3 8.91e-7 Triglyceride levels; CESC cis rs9325144 0.505 rs1906262 chr12:38653605 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.46 0.37 5e-10 Morning vs. evening chronotype; CESC cis rs6580649 0.941 rs4760614 chr12:48427884 A/G cg05342945 chr12:48394962 COL2A1 0.5 5.74 0.33 2.59e-8 Lung cancer; CESC cis rs1348850 0.914 rs11893448 chr2:178280013 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.86 12.77 0.62 1.97e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg11987759 chr7:65425863 GUSB 0.45 6.18 0.35 2.47e-9 Aortic root size; CESC cis rs7937682 0.562 rs10891276 chr11:111370415 A/C cg09085632 chr11:111637200 PPP2R1B -0.64 -8.61 -0.47 6.54e-16 Primary sclerosing cholangitis; CESC cis rs2295499 0.725 rs2298959 chr4:2644311 T/C cg08330972 chr4:2403930 ZFYVE28 -0.32 -5.13 -0.3 5.62e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs9814567 1.000 rs13081177 chr3:134289860 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.1 0.35 3.71e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.33 -5.09 -0.3 6.78e-7 Hip circumference adjusted for BMI; CESC cis rs7520050 0.807 rs6656279 chr1:46124088 C/G cg24296786 chr1:45957014 TESK2 -0.46 -5.96 -0.34 8.19e-9 Red blood cell count;Reticulocyte count; CESC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg07701084 chr6:150067640 NUP43 0.4 5.48 0.32 9.87e-8 Lung cancer; CESC cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg17211192 chr8:82754475 SNX16 -0.52 -6.64 -0.38 1.73e-10 Diastolic blood pressure; CESC cis rs10779751 1.000 rs12730522 chr1:11284091 G/A cg08854313 chr1:11322531 MTOR 0.91 14.25 0.66 1.34e-34 Body mass index; CESC cis rs6500602 0.964 rs2896893 chr16:4478559 T/A cg08645402 chr16:4508243 NA 0.43 6.62 0.38 2.03e-10 Schizophrenia; CESC trans rs7824557 0.527 rs10109537 chr8:11239640 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.07 -0.35 4.35e-9 Retinal vascular caliber; CESC cis rs1707322 0.890 rs2297883 chr1:46511487 G/C cg05343316 chr1:45956843 TESK2 -0.44 -5.44 -0.32 1.2e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs57221529 0.766 rs12522303 chr5:555564 A/C cg09021430 chr5:549028 NA -0.42 -5.26 -0.31 2.92e-7 Lung disease severity in cystic fibrosis; CESC cis rs10769945 0.679 rs217213 chr11:1979118 C/G cg23202291 chr11:1979235 NA -0.37 -5.22 -0.31 3.57e-7 DNA methylation (variation); CESC cis rs7582720 1.000 rs72932558 chr2:203847325 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs9486719 0.895 rs12527021 chr6:97025496 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -8.28 -0.45 6.29e-15 Migraine;Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22331096 chr8:128749328 MYC 0.56 6.4 0.37 7.13e-10 Gut microbiome composition (summer); CESC trans rs1506636 0.886 rs6945841 chr7:123266094 G/A cg12383159 chr11:1262597 MUC5B 0.36 6.14 0.35 3.08e-9 Plateletcrit;Platelet count; CESC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg02187348 chr16:89574699 SPG7 -0.6 -8.53 -0.46 1.1e-15 Multiple myeloma (IgH translocation); CESC cis rs6964587 1.000 rs6967256 chr7:91643219 G/A cg17063962 chr7:91808500 NA 0.55 7.63 0.42 4.25e-13 Breast cancer; CESC cis rs7188697 0.922 rs173475 chr16:58580530 T/C cg02549819 chr16:58548995 SETD6 -0.42 -5.26 -0.31 3.04e-7 QT interval; CESC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg02725872 chr8:58115012 NA -0.45 -6.84 -0.39 5.31e-11 Developmental language disorder (linguistic errors); CESC cis rs870825 0.860 rs2696044 chr4:185595988 C/G cg04058563 chr4:185651563 MLF1IP 0.54 5.52 0.32 8.11e-8 Blood protein levels; CESC cis rs561341 0.714 rs473535 chr17:30312365 A/G cg19193384 chr17:30244184 NA -0.64 -5.99 -0.35 6.79e-9 Hip circumference adjusted for BMI; CESC cis rs4423214 1.000 rs11606612 chr11:71164047 C/A cg05163923 chr11:71159392 DHCR7 0.76 10.16 0.53 1.05e-20 Vitamin D levels; CESC cis rs6783573 1.000 rs12185926 chr3:46602999 C/G cg21489266 chr3:46619131 LRRC2;TDGF1 -0.43 -6.23 -0.36 1.8e-9 Cerebrospinal fluid biomarker levels; CESC cis rs2657888 1.000 rs2657901 chr12:56933416 A/G cg23002907 chr12:56915593 RBMS2 0.39 5.21 0.3 3.78e-7 Adiponectin levels; CESC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg20119798 chr7:94954144 PON1 -0.41 -6.04 -0.35 5.25e-9 Paraoxonase activity; CESC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg08632164 chr7:65971372 NA -0.32 -5.19 -0.3 4.14e-7 Aortic root size; CESC cis rs7618501 0.735 rs9876508 chr3:49780844 G/A cg24308560 chr3:49941425 MST1R 0.49 6.74 0.38 9.66e-11 Intelligence (multi-trait analysis); CESC trans rs4927850 1.000 rs7614767 chr3:195753451 C/T cg16724585 chr3:197361211 NA -0.56 -7.54 -0.42 7.58e-13 Pancreatic cancer; CESC trans rs393155 0.517 rs330050 chr8:9087679 G/C cg15556689 chr8:8085844 FLJ10661 -0.52 -6.57 -0.37 2.61e-10 Neuroticism; CESC cis rs71403859 0.502 rs17345863 chr16:71523261 C/T cg08717414 chr16:71523259 ZNF19 -1.01 -9.55 -0.51 8.95e-19 Post bronchodilator FEV1; CESC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.07 -0.53 2.08e-20 Developmental language disorder (linguistic errors); CESC cis rs2204008 0.665 rs11495668 chr12:38221018 C/T cg26384229 chr12:38710491 ALG10B 0.74 10.65 0.55 2.74e-22 Bladder cancer; CESC cis rs6446731 0.593 rs7674472 chr4:3273538 C/G cg08886695 chr4:3369023 RGS12 -0.38 -5.51 -0.32 8.38e-8 Mean platelet volume; CESC cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg24110177 chr3:50126178 RBM5 -0.54 -7.55 -0.42 7.06e-13 Intelligence (multi-trait analysis); CESC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg10494973 chr17:80897199 TBCD -0.48 -6.09 -0.35 3.92e-9 Breast cancer; CESC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg02951883 chr7:2050386 MAD1L1 -0.56 -7.4 -0.41 1.75e-12 Bipolar disorder and schizophrenia; CESC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg00166722 chr3:10149974 C3orf24 0.45 5.65 0.33 4.12e-8 Alzheimer's disease; CESC cis rs72781680 0.848 rs56021814 chr2:24073437 T/A cg20701182 chr2:24300061 SF3B14 0.62 5.58 0.32 6.04e-8 Lymphocyte counts; CESC cis rs9457247 1.000 rs2757042 chr6:167371234 A/T cg23791538 chr6:167370224 RNASET2 0.57 8.13 0.45 1.64e-14 Crohn's disease; CESC cis rs4654899 1.000 rs12133780 chr1:21270808 G/A cg05370193 chr1:21551575 ECE1 0.39 5.83 0.34 1.6e-8 Superior frontal gyrus grey matter volume; CESC cis rs910316 0.737 rs424120 chr14:75482828 G/T cg16144293 chr14:75469539 EIF2B2 0.39 5.11 0.3 6.28e-7 Height; CESC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1348850 0.526 rs2178017 chr2:178374788 G/T cg22681709 chr2:178499509 PDE11A -0.49 -5.07 -0.3 7.32e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7772486 0.790 rs1133832 chr6:146205604 C/T cg05347473 chr6:146136440 FBXO30 -0.51 -6.84 -0.39 5.6e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs9660992 0.512 rs12123773 chr1:205122420 C/G cg00857998 chr1:205179979 DSTYK 0.58 7.45 0.42 1.34e-12 Mean corpuscular volume;Mean platelet volume; CESC cis rs2880765 0.835 rs7174323 chr15:86049719 A/C cg19183879 chr15:85880815 NA -0.26 -5.29 -0.31 2.52e-7 Coronary artery disease; CESC cis rs6982240 0.514 rs9324543 chr8:142275662 T/C cg00131261 chr8:142287264 NA -0.54 -7.51 -0.42 8.94e-13 Tonsillectomy; CESC cis rs35306767 0.953 rs35174953 chr10:961191 C/A cg26597838 chr10:835615 NA 0.84 9.84 0.52 1.15e-19 Eosinophil percentage of granulocytes; CESC cis rs72792276 0.908 rs3828656 chr5:127487535 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.65 5.71 0.33 3.04e-8 Red cell distribution width; CESC trans rs61931739 0.500 rs7971957 chr12:34477558 C/T cg26384229 chr12:38710491 ALG10B 0.55 7.59 0.42 5.63e-13 Morning vs. evening chronotype; CESC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg23803603 chr1:2058230 PRKCZ -0.34 -5.75 -0.33 2.5e-8 Height; CESC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.09 -0.4 1.24e-11 Total body bone mineral density; CESC cis rs10206020 0.797 rs72778008 chr2:1573182 T/G cg26248373 chr2:1572462 NA -0.6 -7.09 -0.4 1.21e-11 IgG glycosylation; CESC cis rs1129187 0.837 rs4714634 chr6:42901120 G/A cg21280719 chr6:42927975 GNMT -0.25 -5.56 -0.32 6.46e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs2730245 0.569 rs1188955 chr7:158690866 A/G cg14689365 chr7:158441557 NCAPG2 0.41 5.05 0.3 8.24e-7 Height; CESC cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg23711669 chr6:146136114 FBXO30 0.92 11.94 0.59 1.42e-26 Lobe attachment (rater-scored or self-reported); CESC trans rs7980799 0.682 rs1601007 chr12:33609675 C/G cg26384229 chr12:38710491 ALG10B 0.5 7.2 0.4 6.33e-12 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg11663144 chr21:46675770 NA -0.64 -9.99 -0.52 3.77e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.21e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26634707 chr19:59030662 ZBTB45 -0.51 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs2731664 0.792 rs2544809 chr5:176885499 T/C cg23176889 chr5:176863531 GRK6 -0.65 -11.42 -0.57 7.74e-25 Intelligence (multi-trait analysis); CESC cis rs1062177 1.000 rs2915882 chr5:151145436 T/C cg00977110 chr5:151150581 G3BP1 0.67 7.27 0.41 3.98e-12 Preschool internalizing problems; CESC cis rs8040855 0.627 rs12909130 chr15:85590501 T/C cg08123816 chr15:85640762 PDE8A -0.38 -5.66 -0.33 4e-8 Bulimia nervosa; CESC cis rs9522267 0.535 rs9515452 chr13:112234553 A/G cg10483660 chr13:112241077 NA -0.33 -5.79 -0.33 2.04e-8 Hepatitis; CESC cis rs4664304 0.658 rs2667012 chr2:160867553 G/T cg03641300 chr2:160917029 PLA2R1 -0.45 -6.4 -0.37 6.82e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.34 5.8 0.34 1.89e-8 Bipolar disorder; CESC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg06481639 chr22:41940642 POLR3H 0.6 5.95 0.34 8.27e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs3126085 0.935 rs4845423 chr1:152184950 T/G cg26876637 chr1:152193138 HRNR 0.48 5.51 0.32 8.31e-8 Atopic dermatitis; CESC cis rs3806843 0.735 rs6849 chr5:140086191 G/T cg16179182 chr5:140090404 VTRNA1-1 0.4 5.18 0.3 4.46e-7 Depressive symptoms (multi-trait analysis); CESC trans rs7307889 0.793 rs73047639 chr12:6008285 C/G cg18407955 chr7:158110685 PTPRN2 -0.67 -6.29 -0.36 1.33e-9 Obesity-related traits; CESC cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg07697082 chr8:82753677 SNX16 -0.4 -5.69 -0.33 3.32e-8 Diastolic blood pressure; CESC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg13206674 chr6:150067644 NUP43 0.42 5.83 0.34 1.64e-8 Lung cancer; CESC cis rs7582720 1.000 rs114110842 chr2:203823400 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs9296736 1.000 rs4715438 chr6:53901329 G/A cg04374786 chr6:53939321 C6orf142 -0.37 -5.69 -0.33 3.34e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7666738 0.791 rs11097610 chr4:99011795 C/G cg03467027 chr4:99064603 C4orf37 0.45 5.58 0.32 5.85e-8 Colonoscopy-negative controls vs population controls; CESC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs1062177 0.756 rs2915815 chr5:151115883 G/C cg12924095 chr5:151150029 G3BP1 -0.46 -5.78 -0.33 2.06e-8 Preschool internalizing problems; CESC cis rs344364 0.511 rs2906912 chr16:1953151 G/A cg03013636 chr16:1946785 NA 0.47 6.4 0.37 6.98e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs7605827 0.930 rs2049720 chr2:15514982 T/C cg19274914 chr2:15703543 NA 0.31 5.39 0.31 1.55e-7 Educational attainment (years of education); CESC cis rs644799 0.965 rs11021313 chr11:95506907 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.54 6.76 0.38 8.71e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs2274273 0.840 rs11547116 chr14:55738165 T/C cg04306507 chr14:55594613 LGALS3 0.28 5.42 0.32 1.37e-7 Protein biomarker; CESC cis rs2832191 0.791 rs2065270 chr21:30485420 T/C cg08807101 chr21:30365312 RNF160 -0.76 -10.9 -0.56 4.29e-23 Dental caries; CESC cis rs11638352 1.000 rs11631340 chr15:44286325 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.63 -5.6 -0.33 5.48e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs854765 0.506 rs7210400 chr17:17949957 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.56 -8.0 -0.44 3.85e-14 Total body bone mineral density; CESC trans rs801193 0.967 rs2707849 chr7:66152712 T/C cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC cis rs7656342 0.636 rs10012880 chr4:9835480 T/C cg00071950 chr4:10020882 SLC2A9 -0.42 -5.58 -0.32 5.89e-8 Gut microbiota (bacterial taxa); CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg03188948 chr7:1209495 NA 0.43 5.37 0.31 1.75e-7 Longevity;Endometriosis; CESC cis rs7188697 0.922 rs37053 chr16:58558707 T/C cg02549819 chr16:58548995 SETD6 -0.42 -5.23 -0.31 3.45e-7 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22663240 chr12:56473408 ERBB3 0.56 6.45 0.37 5.17e-10 Gut microbiome composition (summer); CESC cis rs5753037 0.653 rs131266 chr22:30145717 G/T cg01021169 chr22:30184971 ASCC2 -0.47 -6.6 -0.38 2.17e-10 Type 1 diabetes; CESC trans rs12505749 1.000 rs12505749 chr4:57334112 C/G cg09583921 chr3:87101925 NA 0.95 6.15 0.35 2.79e-9 Airflow obstruction; CESC cis rs854765 0.964 rs854813 chr17:18003845 C/T cg04398451 chr17:18023971 MYO15A 0.67 9.35 0.5 3.75e-18 Total body bone mineral density; CESC trans rs61931739 0.534 rs4539411 chr12:34014807 T/C cg26384229 chr12:38710491 ALG10B 0.5 6.87 0.39 4.63e-11 Morning vs. evening chronotype; CESC cis rs113835537 0.529 rs4930183 chr11:66255732 C/T cg24851651 chr11:66362959 CCS 0.45 5.62 0.33 4.87e-8 Airway imaging phenotypes; CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg22083815 chr1:32666378 CCDC28B 0.46 6.04 0.35 5.27e-9 Myopia (pathological); CESC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg15782153 chr7:917662 C7orf20 0.47 5.1 0.3 6.59e-7 Cerebrospinal P-tau181p levels; CESC cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.22e-15 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg13206674 chr6:150067644 NUP43 0.43 6.01 0.35 6.08e-9 Lung cancer; CESC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg11859384 chr17:80120422 CCDC57 0.41 5.53 0.32 7.63e-8 Life satisfaction; CESC cis rs1538970 0.924 rs12037201 chr1:45941349 G/T cg03146154 chr1:46216737 IPP 0.46 5.3 0.31 2.49e-7 Platelet count; CESC cis rs9325144 0.560 rs1825802 chr12:38650341 C/T cg26384229 chr12:38710491 ALG10B -0.62 -9.6 -0.51 6.43e-19 Morning vs. evening chronotype; CESC cis rs1707322 0.721 rs4609469 chr1:46117185 C/T cg03146154 chr1:46216737 IPP 0.82 11.52 0.58 3.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9291683 0.509 rs6849717 chr4:9958719 T/C cg11266682 chr4:10021025 SLC2A9 -0.62 -12.43 -0.61 2.85e-28 Bone mineral density; CESC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg02807482 chr3:125708958 NA -0.39 -5.31 -0.31 2.36e-7 Blood pressure (smoking interaction); CESC cis rs1218582 0.688 rs58629129 chr1:154910930 T/C cg03351412 chr1:154909251 PMVK 0.52 6.38 0.36 7.94e-10 Prostate cancer; CESC cis rs7084402 0.905 rs7914888 chr10:60308558 T/C cg07615347 chr10:60278583 BICC1 -0.56 -8.49 -0.46 1.46e-15 Refractive error; CESC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg03934478 chr11:495069 RNH1 0.55 5.36 0.31 1.86e-7 Body mass index; CESC cis rs9323205 0.906 rs11629336 chr14:51686620 A/C cg23942311 chr14:51606299 NA 0.44 5.61 0.33 5.02e-8 Cancer; CESC cis rs7927771 0.524 rs10838739 chr11:47672743 A/G cg18512352 chr11:47633146 NA -0.34 -5.24 -0.31 3.3e-7 Subjective well-being; CESC cis rs73206853 0.925 rs12297709 chr12:110901758 A/G cg12870014 chr12:110450643 ANKRD13A 0.64 5.8 0.34 1.84e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9796 0.700 rs2305656 chr15:41279519 T/A cg18705301 chr15:41695430 NDUFAF1 -0.54 -7.52 -0.42 8.37e-13 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16580496 chr1:38156394 C1orf109 0.59 6.3 0.36 1.27e-9 Gut microbiome composition (summer); CESC cis rs412050 0.547 rs112153746 chr22:22138691 G/A cg17089214 chr22:22089827 YPEL1 0.65 5.36 0.31 1.78e-7 Attention deficit hyperactivity disorder; CESC cis rs2354432 0.607 rs10453880 chr1:146693689 T/C cg25205988 chr1:146714368 CHD1L 1.18 8.99 0.48 4.8e-17 Mitochondrial DNA levels; CESC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg24829409 chr8:58192753 C8orf71 -0.65 -7.84 -0.43 1.13e-13 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26831488 chr11:114270881 RBM7;C11orf71 0.62 6.55 0.37 3.06e-10 Gut microbiome composition (summer); CESC cis rs5753618 0.583 rs5749270 chr22:31812853 C/T cg02404636 chr22:31891804 SFI1 0.39 5.37 0.31 1.71e-7 Colorectal cancer; CESC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg13777783 chr17:79615861 NA -0.37 -6.16 -0.35 2.72e-9 Eye color traits; CESC cis rs977987 0.806 rs4888388 chr16:75394148 G/A cg03315344 chr16:75512273 CHST6 0.39 5.63 0.33 4.61e-8 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18727501 chr4:89513542 HERC3 0.55 6.77 0.38 8.11e-11 Gut microbiome composition (summer); CESC cis rs6088580 0.634 rs4277599 chr20:33008905 A/G cg24642439 chr20:33292090 TP53INP2 -0.55 -7.53 -0.42 8.19e-13 Glomerular filtration rate (creatinine); CESC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg14196790 chr5:131705035 SLC22A5 0.32 5.17 0.3 4.62e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06520258 chr11:118436842 C11orf60 -0.54 -6.48 -0.37 4.45e-10 Gut microbiome composition (summer); CESC cis rs6430585 0.527 rs12465544 chr2:136451676 C/T cg07169764 chr2:136633963 MCM6 1.09 12.56 0.61 1.07e-28 Corneal structure; CESC cis rs6772849 0.930 rs68090762 chr3:128343907 C/T cg16766828 chr3:128327626 NA -0.31 -5.09 -0.3 6.77e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs208520 0.690 rs2126120 chr6:66742754 A/G cg07460842 chr6:66804631 NA 0.97 12.84 0.62 1.11e-29 Exhaled nitric oxide output; CESC cis rs3820068 0.705 rs2145396 chr1:15875184 A/G cg18192808 chr1:15853278 DNAJC16 0.47 5.69 0.33 3.33e-8 Systolic blood pressure; CESC cis rs9309473 0.528 rs11126395 chr2:73564964 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -6.45 -0.37 5.34e-10 Metabolite levels; CESC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg00149659 chr3:10157352 C3orf10 0.72 8.61 0.47 6.41e-16 Alzheimer's disease; CESC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.32 0.54 3.32e-21 Prudent dietary pattern; CESC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg00166722 chr3:10149974 C3orf24 0.48 6.16 0.35 2.64e-9 Alzheimer's disease; CESC cis rs1707322 0.721 rs4660883 chr1:46236098 C/T cg03146154 chr1:46216737 IPP 0.85 12.13 0.6 3.17e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg04518342 chr5:131593106 PDLIM4 -0.42 -6.29 -0.36 1.28e-9 Breast cancer; CESC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg18538332 chr22:24372958 LOC391322 -0.73 -10.92 -0.56 3.57e-23 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs916888 0.779 rs199528 chr17:44843136 C/T cg01570182 chr17:44337453 NA 0.93 10.7 0.55 1.93e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg25517755 chr10:38738941 LOC399744 -0.47 -6.16 -0.35 2.76e-9 Extrinsic epigenetic age acceleration; CESC cis rs55728055 0.661 rs62237764 chr22:31947393 T/G cg01338084 chr22:32026380 PISD 1.26 8.11 0.45 1.91e-14 Age-related hearing impairment; CESC cis rs807669 0.525 rs9604934 chr22:19194868 C/T cg17887427 chr22:19166691 SLC25A1 -0.38 -5.08 -0.3 7.27e-7 Metabolite levels; CESC cis rs1448094 0.842 rs10863159 chr12:86459140 T/C cg02569458 chr12:86230093 RASSF9 -0.35 -5.31 -0.31 2.33e-7 Major depressive disorder; CESC cis rs727505 1.000 rs67084428 chr7:124499388 G/T cg23710748 chr7:124431027 NA -0.48 -7.52 -0.42 8.73e-13 Lewy body disease; CESC cis rs9443189 0.530 rs614065 chr6:76315633 G/A cg01950844 chr6:76311363 SENP6 0.88 9.44 0.5 2.07e-18 Prostate cancer; CESC cis rs6736093 0.966 rs11674891 chr2:112713116 A/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.46 -0.32 1.1e-7 Coronary artery disease; CESC cis rs9911578 0.704 rs72628393 chr17:56585314 A/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.42 -5.58 -0.32 5.86e-8 Intelligence (multi-trait analysis); CESC cis rs10870270 1.000 rs10159746 chr10:133742677 C/T cg17892150 chr10:133769511 PPP2R2D -0.86 -12.69 -0.61 3.83e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs1881744 1.000 rs7298217 chr12:47809049 A/C cg18786123 chr12:47787067 NA 0.66 5.27 0.31 2.88e-7 Metabolite levels (HVA/5-HIAA ratio); CESC cis rs1801251 1.000 rs6761324 chr2:233582793 T/G cg25237894 chr2:233734115 C2orf82 0.51 8.57 0.47 8.75e-16 Coronary artery disease; CESC cis rs798554 0.660 rs798480 chr7:2805597 G/T cg09658497 chr7:2847517 GNA12 -0.35 -5.13 -0.3 5.56e-7 Height; CESC cis rs385076 0.502 rs13013695 chr2:32391231 G/A cg02381751 chr2:32503542 YIPF4 -0.56 -6.47 -0.37 4.63e-10 Interleukin-18 levels; CESC cis rs977987 0.778 rs35214308 chr16:75476088 C/T cg03315344 chr16:75512273 CHST6 0.43 6.13 0.35 3.23e-9 Dupuytren's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24327541 chr19:8570921 NA 0.6 7.55 0.42 7.05e-13 Gut microbiome composition (summer); CESC cis rs4332037 0.508 rs56758848 chr7:1868727 A/G cg23422044 chr7:1970798 MAD1L1 -0.51 -5.12 -0.3 5.76e-7 Bipolar disorder; CESC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg18230493 chr5:56204884 C5orf35 -0.72 -8.57 -0.47 8.6e-16 Initial pursuit acceleration; CESC cis rs2485892 0.553 rs2494191 chr1:210346053 G/C cg22029157 chr1:209979665 IRF6 0.51 5.73 0.33 2.76e-8 Manic episodes in bipolar disorder; CESC trans rs61931739 0.534 rs11052957 chr12:33995354 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.63 0.38 1.9e-10 Morning vs. evening chronotype; CESC cis rs7940866 0.801 rs10894288 chr11:130808679 T/C cg12179176 chr11:130786555 SNX19 0.65 10.04 0.52 2.6e-20 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17854747 chr18:29672535 RNF138 -0.54 -6.14 -0.35 2.99e-9 Gut microbiome composition (summer); CESC cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg13072238 chr3:49761600 GMPPB -0.51 -5.98 -0.35 7.05e-9 Menarche (age at onset); CESC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg11644478 chr21:40555479 PSMG1 1.02 16.64 0.71 4.59e-43 Cognitive function; CESC cis rs2573652 1.000 rs2581363 chr15:100513364 G/A cg09918751 chr15:100517450 ADAMTS17 -0.38 -7.42 -0.41 1.55e-12 Height; CESC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg11890956 chr21:40555474 PSMG1 1.18 21.95 0.8 1.42e-61 Cognitive function; CESC cis rs2952156 0.684 rs11658786 chr17:37815899 G/A cg20243544 chr17:37824526 PNMT 0.65 8.83 0.48 1.46e-16 Asthma; CESC cis rs2279817 0.863 rs12139706 chr1:18026435 G/A cg21791023 chr1:18019539 ARHGEF10L 0.52 7.77 0.43 1.7e-13 Neuroticism; CESC cis rs6580649 1.000 rs9805048 chr12:48403692 C/T cg24011408 chr12:48396354 COL2A1 0.38 5.11 0.3 6.28e-7 Lung cancer; CESC cis rs9486715 0.929 rs7775721 chr6:97056979 C/T cg18709589 chr6:96969512 KIAA0776 -0.44 -6.1 -0.35 3.76e-9 Headache; CESC cis rs2243480 1.000 rs2462569 chr7:65474846 C/T cg25894440 chr7:65020034 NA 0.57 5.04 0.3 8.44e-7 Diabetic kidney disease; CESC cis rs3008870 1.000 rs2985824 chr1:67410171 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.05 -15.15 -0.68 9.32e-38 Lymphocyte percentage of white cells; CESC cis rs12413816 0.818 rs35567671 chr10:13769722 C/A cg16485048 chr10:13749193 FRMD4A 0.47 5.85 0.34 1.42e-8 Red cell distribution width; CESC cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg00409905 chr10:38381863 ZNF37A -0.45 -6.0 -0.35 6.61e-9 Extrinsic epigenetic age acceleration; CESC trans rs9858542 0.953 rs9811982 chr3:49624377 A/C cg21659725 chr3:3221576 CRBN -0.53 -6.41 -0.37 6.75e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs2404602 0.735 rs2436994 chr15:76801063 G/C cg23625390 chr15:77176239 SCAPER -0.37 -5.16 -0.3 4.73e-7 Blood metabolite levels; CESC cis rs2204008 0.774 rs11615665 chr12:38328162 T/A cg13010199 chr12:38710504 ALG10B 0.47 6.0 0.35 6.62e-9 Bladder cancer; CESC cis rs6893300 0.961 rs11741570 chr5:179208910 A/G cg14593053 chr5:179126677 CANX -0.52 -5.79 -0.33 2.03e-8 Resting heart rate; CESC cis rs9488822 0.651 rs3798228 chr6:116321156 T/C cg15226275 chr6:116381976 FRK 0.25 6.22 0.36 1.94e-9 Cholesterol, total;LDL cholesterol; CESC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg11764359 chr7:65958608 NA -0.81 -9.0 -0.48 4.57e-17 Aortic root size; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg07236925 chr15:91498269 RCCD1 -0.46 -6.03 -0.35 5.56e-9 Height; CESC cis rs847577 0.609 rs11763970 chr7:97817321 A/G cg24562669 chr7:97807699 LMTK2 0.83 13.76 0.65 7.13e-33 Breast cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26869362 chr11:105947257 KBTBD3;AASDHPPT 0.36 6.07 0.35 4.46e-9 Gambling; CESC cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg22875332 chr1:76189707 ACADM 0.7 9.26 0.49 7.34e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11264213 0.786 rs72659696 chr1:36313665 G/A cg27506609 chr1:36549197 TEKT2 0.65 5.49 0.32 9.31e-8 Schizophrenia; CESC cis rs8114671 0.562 rs6120758 chr20:33492523 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.19 0.3 4.19e-7 Height; CESC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg11247378 chr22:39784982 NA -0.63 -8.59 -0.47 7.61e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs367943 0.634 rs2195377 chr5:112973620 G/A cg12552261 chr5:112820674 MCC 0.44 5.63 0.33 4.63e-8 Type 2 diabetes; CESC cis rs2742234 0.541 rs10899786 chr10:43744583 G/A cg15436174 chr10:43711423 RASGEF1A 0.46 5.33 0.31 2.14e-7 Hirschsprung disease; CESC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg06028605 chr16:24865363 SLC5A11 -0.56 -7.83 -0.43 1.2e-13 Intelligence (multi-trait analysis); CESC cis rs36051895 0.632 rs12344116 chr9:5142216 G/A cg02405213 chr9:5042618 JAK2 -0.5 -6.27 -0.36 1.49e-9 Pediatric autoimmune diseases; CESC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg11644478 chr21:40555479 PSMG1 1.04 17.8 0.74 3.62e-47 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24327397 chr15:83478411 WHAMM 0.63 7.19 0.4 6.68e-12 Gut microbiome composition (summer); CESC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg24690094 chr11:67383802 NA 0.36 6.01 0.35 6.22e-9 Mean corpuscular volume; CESC cis rs61931739 0.500 rs11053273 chr12:34547255 C/T cg19457237 chr12:34500585 NA -0.37 -5.08 -0.3 6.97e-7 Morning vs. evening chronotype; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08538778 chr1:115212897 DENND2C 0.42 6.24 0.36 1.71e-9 Systemic lupus erythematosus; CESC cis rs12956009 0.583 rs12965907 chr18:44888455 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.59 0.38 2.42e-10 Educational attainment (years of education); CESC cis rs8062405 1.000 rs2008514 chr16:28825605 A/G cg08761264 chr16:28874980 SH2B1 0.46 5.72 0.33 2.85e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg05090351 chr10:126851162 NA -0.77 -13.26 -0.63 3.94e-31 Menarche (age at onset); CESC cis rs897984 0.759 rs13708 chr16:31000809 G/A cg00531865 chr16:30841666 NA 0.5 6.87 0.39 4.7e-11 Dementia with Lewy bodies; CESC cis rs12347191 0.500 rs907580 chr9:100622597 T/C cg13688889 chr9:100608707 NA -0.89 -13.0 -0.62 3.11e-30 Orofacial clefts; CESC trans rs11098499 0.618 rs35265692 chr4:120325135 T/C cg25214090 chr10:38739885 LOC399744 0.7 9.6 0.51 6.27e-19 Corneal astigmatism; CESC cis rs863345 0.604 rs59427353 chr1:158500621 A/C cg12129480 chr1:158549410 OR10X1 -0.34 -6.76 -0.38 8.6e-11 Pneumococcal bacteremia; CESC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg13206674 chr6:150067644 NUP43 0.45 6.43 0.37 5.79e-10 Lung cancer; CESC cis rs1348850 0.526 rs6723014 chr2:178410586 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.67 6.09 0.35 3.87e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7084402 0.967 rs1365740 chr10:60277549 A/C cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.94e-18 Refractive error; CESC cis rs7833986 0.534 rs17814089 chr8:56965563 A/G cg23139584 chr8:56987506 RPS20;SNORD54 -0.6 -7.45 -0.42 1.29e-12 Height; CESC cis rs2243480 0.901 rs778687 chr7:65835819 G/A cg12463550 chr7:65579703 CRCP 0.71 5.49 0.32 9.37e-8 Diabetic kidney disease; CESC cis rs4523957 0.928 rs216180 chr17:2172416 C/G cg16513277 chr17:2031491 SMG6 0.59 7.99 0.44 4.21e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7666738 0.546 rs9993299 chr4:98815976 G/A cg17366294 chr4:99064904 C4orf37 0.48 5.8 0.34 1.84e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 0.708 rs35825036 chr7:65986502 T/C cg12463550 chr7:65579703 CRCP 0.72 5.55 0.32 6.96e-8 Diabetic kidney disease; CESC cis rs6732160 0.631 rs7557285 chr2:73442812 G/A cg01422370 chr2:73384389 NA 0.43 7.28 0.41 3.72e-12 Intelligence (multi-trait analysis); CESC cis rs12682352 0.602 rs11783966 chr8:8665147 A/G cg17143192 chr8:8559678 CLDN23 -0.42 -5.07 -0.3 7.58e-7 Neuroticism; CESC cis rs8072100 0.777 rs9914653 chr17:45537395 T/C cg08085267 chr17:45401833 C17orf57 -0.55 -7.41 -0.41 1.68e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg18769074 chr3:133464867 TF 0.32 5.89 0.34 1.19e-8 Iron status biomarkers; CESC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg03264133 chr6:25882463 NA 0.47 6.7 0.38 1.27e-10 Intelligence (multi-trait analysis); CESC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg10691866 chr7:65817282 TPST1 -0.33 -5.43 -0.32 1.3e-7 Aortic root size; CESC cis rs7078219 0.505 rs6584281 chr10:101286480 A/G cg09788492 chr10:101292477 NKX2-3 0.33 6.28 0.36 1.37e-9 Dental caries; CESC cis rs1707322 0.963 rs4459051 chr1:46451203 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs36051895 0.626 rs10283564 chr9:5075628 C/G cg02405213 chr9:5042618 JAK2 -0.49 -5.97 -0.34 7.79e-9 Pediatric autoimmune diseases; CESC cis rs9911578 0.839 rs7208505 chr17:57187729 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -6.74 -0.38 1.01e-10 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.26 0.36 1.57e-9 Menopause (age at onset); CESC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg04414720 chr1:150670196 GOLPH3L 0.48 6.53 0.37 3.26e-10 Melanoma; CESC cis rs6500602 0.727 rs11644481 chr16:4581002 T/G cg08645402 chr16:4508243 NA 0.51 8.34 0.46 4.21e-15 Schizophrenia; CESC cis rs11577318 0.853 rs4333841 chr1:26631927 T/C cg00852783 chr1:26633632 UBXN11 0.5 6.99 0.39 2.17e-11 Granulocyte percentage of myeloid white cells; CESC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg21724239 chr8:58056113 NA 0.58 5.93 0.34 9.45e-9 Developmental language disorder (linguistic errors); CESC cis rs13102973 0.965 rs10434072 chr4:135867883 C/T cg14419869 chr4:135874104 NA -0.4 -6.29 -0.36 1.32e-9 Subjective well-being; CESC cis rs6736093 1.000 rs13006203 chr2:112661150 G/A cg12686935 chr2:112915763 FBLN7 -0.42 -5.17 -0.3 4.56e-7 Coronary artery disease; CESC cis rs6088580 0.634 rs4911153 chr20:32961547 C/T cg06115741 chr20:33292138 TP53INP2 -0.45 -5.73 -0.33 2.67e-8 Glomerular filtration rate (creatinine); CESC cis rs910316 0.737 rs175424 chr14:75626257 T/C cg11812906 chr14:75593930 NEK9 -0.79 -12.24 -0.6 1.36e-27 Height; CESC cis rs765787 0.530 rs4331289 chr15:45515338 C/T cg24006582 chr15:45444508 DUOX1 -0.58 -7.11 -0.4 1.11e-11 Uric acid levels; CESC cis rs4964805 0.657 rs1866294 chr12:104186795 A/G cg02344784 chr12:104178138 NT5DC3 0.46 6.57 0.37 2.73e-10 Attention deficit hyperactivity disorder; CESC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg20151795 chr6:28129481 ZNF389 -0.41 -5.2 -0.3 3.9e-7 Parkinson's disease; CESC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg20891558 chr2:74357851 NA 0.81 12.0 0.59 8.82e-27 Gestational age at birth (maternal effect); CESC cis rs3736485 0.966 rs10467924 chr15:51787579 A/G cg08986416 chr15:51914746 DMXL2 -0.41 -5.3 -0.31 2.39e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7927771 0.524 rs7124396 chr11:47787434 T/G cg18512352 chr11:47633146 NA -0.35 -5.47 -0.32 1.03e-7 Subjective well-being; CESC cis rs2439831 1.000 rs537115 chr15:43729948 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.6 0.55 4.2e-22 Lung cancer in ever smokers; CESC cis rs6460942 0.597 rs17448193 chr7:12525641 G/A cg06484146 chr7:12443880 VWDE -0.71 -7.69 -0.43 2.88e-13 Coronary artery disease; CESC cis rs763121 0.925 rs4821815 chr22:39105707 G/A cg06544989 chr22:39130855 UNC84B 0.54 10.36 0.54 2.52e-21 Menopause (age at onset); CESC cis rs10751667 1.000 rs7395632 chr11:958789 C/T cg01483505 chr11:975446 AP2A2 -0.38 -5.16 -0.3 4.88e-7 Alzheimer's disease (late onset); CESC cis rs8180040 0.966 rs807932 chr3:47354241 C/T cg27129171 chr3:47204927 SETD2 0.66 10.1 0.53 1.7e-20 Colorectal cancer; CESC cis rs11958404 0.860 rs72818136 chr5:157462866 C/T cg05962755 chr5:157440814 NA 0.62 7.21 0.4 5.94e-12 IgG glycosylation; CESC cis rs12530845 1.000 rs78186690 chr7:135334991 G/C cg23117316 chr7:135346802 PL-5283 -0.4 -5.15 -0.3 4.98e-7 Red blood cell traits; CESC cis rs7216064 1.000 rs12600941 chr17:65918807 A/G cg07042672 chr17:66097459 LOC651250 -0.51 -5.31 -0.31 2.36e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9910055 0.550 rs113844752 chr17:42297631 C/A cg19774624 chr17:42201019 HDAC5 -0.46 -5.9 -0.34 1.08e-8 Total body bone mineral density; CESC cis rs6582630 0.502 rs8186661 chr12:38380781 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.65 0.55 2.87e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs9640161 0.789 rs10282458 chr7:150045302 C/T cg17279839 chr7:150038598 RARRES2 0.46 5.65 0.33 4.15e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs6500395 0.962 rs1564979 chr16:48647017 C/A cg04672837 chr16:48644449 N4BP1 0.47 5.57 0.32 6.4e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs56104184 0.723 rs73063515 chr19:49407715 C/T cg21252483 chr19:49399788 TULP2 -0.52 -5.72 -0.33 2.94e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs9837602 0.938 rs1017968 chr3:99787011 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.5 7.15 0.4 8.2e-12 Breast cancer; CESC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg06456125 chr7:65229604 NA 0.39 5.05 0.3 8.06e-7 Aortic root size; CESC cis rs1348850 0.526 rs935426 chr2:178369433 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.68 6.17 0.35 2.52e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs3825932 0.659 rs4778724 chr15:79238406 C/T cg25744700 chr15:79237217 CTSH 0.49 6.4 0.37 7.01e-10 Type 1 diabetes; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01662158 chr6:156030265 NA 0.38 6.0 0.35 6.47e-9 Fibrinogen levels; CESC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg17221315 chr6:27791827 HIST1H4J -0.45 -6.21 -0.36 2.07e-9 Parkinson's disease; CESC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg18337363 chr3:52569053 NT5DC2 0.33 6.42 0.37 6.27e-10 Hemoglobin concentration; CESC cis rs17021463 0.726 rs62320444 chr4:95261251 C/T cg11021082 chr4:95130006 SMARCAD1 0.51 7.58 0.42 5.93e-13 Testicular germ cell tumor; CESC cis rs7520050 0.807 rs3013594 chr1:46138000 T/C cg24296786 chr1:45957014 TESK2 -0.46 -5.68 -0.33 3.5e-8 Red blood cell count;Reticulocyte count; CESC trans rs57221529 0.713 rs72703072 chr5:590626 A/G cg25482853 chr8:67687455 SGK3 1.0 10.02 0.52 2.99e-20 Lung disease severity in cystic fibrosis; CESC cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg11752832 chr7:134001865 SLC35B4 0.54 7.02 0.4 1.91e-11 Mean platelet volume; CESC cis rs10979 1.000 rs6905264 chr6:143894378 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs9894429 0.682 rs7406360 chr17:79591545 G/A cg18240062 chr17:79603768 NPLOC4 0.9 13.2 0.63 6.66e-31 Eye color traits; CESC cis rs2408955 0.521 rs10875753 chr12:48557141 C/T cg24011408 chr12:48396354 COL2A1 0.48 7.34 0.41 2.63e-12 Glycated hemoglobin levels; CESC cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.66 0.61 4.76e-29 Colonoscopy-negative controls vs population controls; CESC cis rs12973672 0.812 rs2280745 chr19:35756178 T/C cg12095397 chr19:35769544 USF2 0.5 6.01 0.35 6.19e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg18876405 chr7:65276391 NA 0.45 6.09 0.35 3.92e-9 Aortic root size; CESC cis rs5753618 0.504 rs9606846 chr22:31897571 C/T cg02404636 chr22:31891804 SFI1 0.42 5.7 0.33 3.25e-8 Colorectal cancer; CESC cis rs8060686 0.920 rs12448923 chr16:67839128 C/T cg26727032 chr16:67993705 SLC12A4 -0.58 -6.26 -0.36 1.51e-9 HDL cholesterol;Metabolic syndrome; CESC cis rs208520 1.000 rs208535 chr6:66962286 G/A cg07460842 chr6:66804631 NA -0.9 -10.34 -0.54 2.79e-21 Exhaled nitric oxide output; CESC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg11890956 chr21:40555474 PSMG1 -0.94 -14.78 -0.67 1.79e-36 Cognitive function; CESC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.72e-10 Life satisfaction; CESC cis rs79349575 0.594 rs1985785 chr17:46967788 T/C cg16584676 chr17:46985605 UBE2Z 0.55 6.69 0.38 1.29e-10 Type 2 diabetes; CESC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg17949981 chr6:28129498 ZNF389 0.48 6.14 0.35 3.05e-9 Depression; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg10822314 chr22:43547440 TSPO -0.46 -6.46 -0.37 4.9e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs2730245 0.527 rs62476462 chr7:158686619 A/G cg24397884 chr7:158709396 WDR60 0.85 8.84 0.48 1.41e-16 Height; CESC cis rs753778 0.962 rs2043422 chr8:142236337 C/T cg23750338 chr8:142222470 SLC45A4 0.36 5.18 0.3 4.41e-7 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs2274273 0.837 rs6573010 chr14:55721592 T/C cg04306507 chr14:55594613 LGALS3 0.29 5.83 0.34 1.65e-8 Protein biomarker; CESC cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.34 5.41 0.32 1.39e-7 Monocyte percentage of white cells; CESC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg21285383 chr16:89894308 SPIRE2 0.32 5.77 0.33 2.15e-8 Vitiligo; CESC cis rs2599510 0.703 rs762023 chr2:32713170 G/A cg02381751 chr2:32503542 YIPF4 0.48 6.09 0.35 3.94e-9 Interleukin-18 levels; CESC cis rs9894429 1.000 rs9894429 chr17:79596811 C/T cg18240062 chr17:79603768 NPLOC4 0.73 10.27 0.53 4.66e-21 Eye color traits; CESC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg14393609 chr7:65229607 NA 0.48 6.38 0.37 7.71e-10 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10058540 chr12:57941150 DCTN2 -0.63 -7.47 -0.42 1.16e-12 Gut microbiome composition (summer); CESC cis rs367943 0.965 rs458044 chr5:112797779 A/G cg12552261 chr5:112820674 MCC -0.62 -7.66 -0.43 3.5e-13 Type 2 diabetes; CESC cis rs365132 0.870 rs2454949 chr5:176466011 G/A cg16309518 chr5:176445507 NA -0.42 -6.16 -0.35 2.75e-9 Menarche and menopause (age at onset);Menopause (age at onset); CESC cis rs17826219 0.706 rs9893922 chr17:29068425 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Body mass index; CESC cis rs11203032 0.831 rs10430718 chr10:90937951 A/T cg16672925 chr10:90967113 CH25H 0.72 7.18 0.4 7.03e-12 Heart failure; CESC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg13880726 chr7:1868755 MAD1L1 0.54 7.25 0.41 4.45e-12 Bipolar disorder and schizophrenia; CESC cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.77 12.94 0.62 5.09e-30 Personality dimensions; CESC cis rs834811 0.831 rs1097147 chr7:135880446 C/T cg01726295 chr7:135938950 NA 0.36 6.1 0.35 3.65e-9 Post-traumatic stress disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11065262 chr2:191878861 STAT1 0.55 6.1 0.35 3.66e-9 Gut microbiome composition (summer); CESC cis rs7084402 0.934 rs1658441 chr10:60323021 G/C cg07615347 chr10:60278583 BICC1 0.61 9.62 0.51 5.56e-19 Refractive error; CESC cis rs12618769 0.652 rs3769698 chr2:99233894 T/C cg10123293 chr2:99228465 UNC50 0.4 5.41 0.32 1.39e-7 Bipolar disorder; CESC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.49 6.99 0.39 2.22e-11 Bipolar disorder; CESC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 13.04 0.63 2.35e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs10870270 0.917 rs9971362 chr10:133790150 T/C cg26149184 chr10:133730230 NA 0.38 5.12 0.3 5.86e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09175718 chr10:97453958 TCTN3 0.52 6.16 0.35 2.68e-9 Gut microbiome composition (summer); CESC cis rs61776719 0.747 rs28428561 chr1:38434306 G/A cg26528311 chr1:38462546 FHL3 -0.39 -6.35 -0.36 9.31e-10 Coronary artery disease; CESC cis rs10899021 1.000 rs10899021 chr11:74338054 C/T cg25880958 chr11:74394337 NA 0.71 7.68 0.43 3.15e-13 Response to metformin (IC50); CESC cis rs13102973 0.965 rs4331828 chr4:135849100 C/G cg14419869 chr4:135874104 NA 0.33 5.19 0.3 4.29e-7 Subjective well-being; CESC cis rs4474465 0.850 rs7112872 chr11:78227396 C/A cg27205649 chr11:78285834 NARS2 0.46 5.61 0.33 5.18e-8 Alzheimer's disease (survival time); CESC cis rs1712517 0.566 rs7917388 chr10:105054963 C/T cg04362960 chr10:104952993 NT5C2 -0.46 -5.55 -0.32 6.98e-8 Migraine; CESC cis rs7188697 0.922 rs246196 chr16:58574253 T/C cg21335942 chr16:58549945 SETD6 0.46 5.36 0.31 1.84e-7 QT interval; CESC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg11301795 chr4:187892539 NA 0.73 11.44 0.57 6.89e-25 Lobe attachment (rater-scored or self-reported); CESC trans rs7246760 0.609 rs57889827 chr19:9777459 T/C cg02900749 chr2:68251473 NA -0.85 -7.53 -0.42 8.04e-13 Pursuit maintenance gain; CESC cis rs897984 0.572 rs4889526 chr16:31030344 C/A cg02466173 chr16:30829666 NA -0.38 -6.48 -0.37 4.36e-10 Dementia with Lewy bodies; CESC cis rs34172651 0.874 rs200534 chr16:24752641 G/A cg06028605 chr16:24865363 SLC5A11 -0.42 -6.28 -0.36 1.38e-9 Intelligence (multi-trait analysis); CESC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 13.05 0.63 2.22e-30 Platelet count; CESC trans rs11098499 0.874 rs12509054 chr4:120115075 A/C cg25214090 chr10:38739885 LOC399744 0.61 8.04 0.44 2.91e-14 Corneal astigmatism; CESC cis rs7017914 0.967 rs13274381 chr8:71765094 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.44 -5.56 -0.32 6.74e-8 Bone mineral density; CESC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.54 -8.02 -0.44 3.42e-14 Bipolar disorder; CESC cis rs78456975 0.527 rs72778003 chr2:1571487 G/A cg26248373 chr2:1572462 NA -0.57 -6.52 -0.37 3.58e-10 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs3136441 0.901 rs11039002 chr11:46857279 T/C cg25783544 chr11:47291846 MADD 0.53 5.06 0.3 7.79e-7 HDL cholesterol; CESC cis rs9611565 0.729 rs2413646 chr22:41906325 C/T cg06481639 chr22:41940642 POLR3H -0.64 -6.6 -0.38 2.21e-10 Vitiligo; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08466385 chr6:18368294 NA 0.43 6.26 0.36 1.52e-9 Fibrinogen levels; CESC cis rs6120849 0.707 rs6088690 chr20:33633326 A/G cg24642439 chr20:33292090 TP53INP2 0.68 6.77 0.38 8.46e-11 Protein C levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24824997 chr2:220507347 NA -0.44 -6.09 -0.35 3.86e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.33 0.5 4.32e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg03467027 chr4:99064603 C4orf37 0.42 5.04 0.3 8.53e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg11494091 chr17:61959527 GH2 0.72 12.33 0.6 6.37e-28 Prudent dietary pattern; CESC cis rs34779708 0.931 rs35317849 chr10:35285721 C/A cg03585969 chr10:35415529 CREM 0.77 10.22 0.53 6.85e-21 Inflammatory bowel disease;Crohn's disease; CESC cis rs6496667 0.509 rs6496677 chr15:90990358 A/G cg10434728 chr15:90938212 IQGAP1 0.3 5.26 0.31 2.94e-7 Rheumatoid arthritis; CESC cis rs7044106 0.762 rs13291660 chr9:123392748 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 9.27 0.49 6.93e-18 Hip circumference adjusted for BMI; CESC cis rs9733 0.715 rs7534124 chr1:150739073 C/T cg18016565 chr1:150552671 MCL1 -0.36 -5.95 -0.34 8.45e-9 Tonsillectomy; CESC cis rs10504073 0.584 rs11778863 chr8:49954893 C/T cg00325661 chr8:49890786 NA 0.59 8.9 0.48 9.3e-17 Blood metabolite ratios; CESC cis rs9467711 0.606 rs9366655 chr6:26377385 C/G cg14345882 chr6:26364793 BTN3A2 0.6 6.57 0.37 2.64e-10 Autism spectrum disorder or schizophrenia; CESC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.31 -0.31 2.34e-7 Life satisfaction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22660933 chr17:46608355 HOXB1 -0.56 -6.36 -0.36 8.86e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19037388 chr19:19774945 ATP13A1 -0.57 -6.49 -0.37 4.09e-10 Gut microbiome composition (summer); CESC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg07092213 chr7:1199455 ZFAND2A -0.38 -5.1 -0.3 6.37e-7 Longevity;Endometriosis; CESC cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg05340658 chr4:99064831 C4orf37 0.82 13.05 0.63 2.08e-30 Colonoscopy-negative controls vs population controls; CESC cis rs992157 0.710 rs10167446 chr2:219056866 A/G cg00012203 chr2:219082015 ARPC2 0.82 11.67 0.58 1.18e-25 Colorectal cancer; CESC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg07936489 chr17:37558343 FBXL20 -0.81 -11.78 -0.59 4.78e-26 Glomerular filtration rate (creatinine); CESC cis rs3820928 0.874 rs10202239 chr2:227901819 C/T cg05526886 chr2:227700861 RHBDD1 -0.45 -5.7 -0.33 3.25e-8 Pulmonary function; CESC cis rs5758659 1.000 rs5758660 chr22:42623718 C/A cg15557168 chr22:42548783 NA -0.48 -7.65 -0.43 3.74e-13 Cognitive function; CESC cis rs3825932 0.778 rs1036938 chr15:79237247 C/G cg25744700 chr15:79237217 CTSH 0.49 6.46 0.37 5.06e-10 Type 1 diabetes; CESC cis rs9611565 0.649 rs202666 chr22:41814719 T/C cg06481639 chr22:41940642 POLR3H 0.61 6.41 0.37 6.55e-10 Vitiligo; CESC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg22907277 chr7:1156413 C7orf50 0.45 5.03 0.3 9.22e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs17039065 0.920 rs7671977 chr4:109435999 T/C cg27151770 chr16:49620536 ZNF423 -0.51 -6.21 -0.36 2.09e-9 Gut microbiome composition (summer); CESC cis rs4660306 0.677 rs781060 chr1:45934166 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.2 0.3 3.91e-7 Homocysteine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07944278 chr6:35699425 LOC285847 0.57 6.47 0.37 4.67e-10 Gut microbiome composition (summer); CESC cis rs8072100 0.869 rs4439799 chr17:45781599 C/T cg08085267 chr17:45401833 C17orf57 -0.39 -5.05 -0.3 8.17e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1055129 0.560 rs9891076 chr17:73911715 C/T cg08125733 chr17:73851984 WBP2 0.52 7.12 0.4 9.85e-12 White matter hyperintensity burden; CESC cis rs9549367 0.826 rs1885688 chr13:113894236 G/T cg18105134 chr13:113819100 PROZ -0.69 -8.63 -0.47 5.71e-16 Platelet distribution width; CESC cis rs477895 0.838 rs72922039 chr11:64013116 A/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.9 10.01 0.52 3.13e-20 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10582639 chr11:121526840 NA 0.59 6.55 0.37 2.94e-10 Gut microbiome composition (summer); CESC cis rs2011503 1.000 rs2060275 chr19:19536208 G/C cg11584989 chr19:19387371 SF4 0.62 7.23 0.41 5.15e-12 Bipolar disorder; CESC cis rs4561483 0.801 rs33649 chr16:11979608 G/C cg08843971 chr16:11963173 GSPT1 -0.54 -7.99 -0.44 4.22e-14 Testicular germ cell tumor; CESC cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg03467027 chr4:99064603 C4orf37 0.43 5.47 0.32 1.03e-7 Colonoscopy-negative controls vs population controls; CESC cis rs668210 0.643 rs549334 chr11:65774659 C/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.68 7.46 0.42 1.26e-12 Cerebrospinal fluid biomarker levels; CESC cis rs6430585 0.528 rs6711493 chr2:136692553 A/G cg07169764 chr2:136633963 MCM6 1.11 16.72 0.72 2.51e-43 Corneal structure; CESC cis rs7086627 0.515 rs10887901 chr10:82210581 G/A cg00277334 chr10:82204260 NA -0.91 -15.99 -0.7 9.29e-41 Post bronchodilator FEV1; CESC cis rs2075371 0.829 rs11770521 chr7:133936251 A/C cg00033643 chr7:134001901 SLC35B4 0.42 5.34 0.31 1.97e-7 Mean platelet volume; CESC cis rs7937682 0.924 rs1784782 chr11:111525764 A/C cg22437258 chr11:111473054 SIK2 0.7 9.35 0.5 3.83e-18 Primary sclerosing cholangitis; CESC cis rs1707322 0.721 rs4431884 chr1:46101323 C/T cg03146154 chr1:46216737 IPP 0.76 10.71 0.55 1.75e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs13333054 1.000 rs12232384 chr16:86009760 A/C cg04454285 chr16:86016317 NA -0.42 -5.11 -0.3 6.08e-7 Multiple sclerosis; CESC cis rs887829 0.569 rs4663333 chr2:234655303 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -6.25 -0.36 1.6e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs9894429 0.646 rs6565612 chr17:79602820 C/T cg18240062 chr17:79603768 NPLOC4 -0.55 -7.17 -0.4 7.36e-12 Eye color traits; CESC cis rs3857536 0.740 rs7773577 chr6:66892124 G/A cg07460842 chr6:66804631 NA -0.4 -5.23 -0.31 3.47e-7 Blood trace element (Cu levels); CESC cis rs798766 1.000 rs798766 chr4:1734239 C/T cg10756475 chr4:1757242 NA -0.44 -5.74 -0.33 2.57e-8 Bladder cancer;Urinary bladder cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15003434 chr9:136202985 SURF6 0.51 6.02 0.35 5.93e-9 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs73271869 chr17:29152221 G/A cg13385521 chr17:29058706 SUZ12P 0.75 6.0 0.35 6.29e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg03188948 chr7:1209495 NA 0.71 7.06 0.4 1.5e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2243480 0.708 rs35825036 chr7:65986502 T/C cg13147721 chr7:65941812 NA -0.95 -8.91 -0.48 8.34e-17 Diabetic kidney disease; CESC cis rs13385 0.769 rs7704262 chr5:139611043 T/A cg26211634 chr5:139558579 C5orf32 0.47 5.19 0.3 4.23e-7 Atrial fibrillation; CESC cis rs1514687 0.534 rs58529796 chr2:1473693 C/T cg13703866 chr2:1479523 TPO -0.77 -5.24 -0.31 3.35e-7 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19871361 chr10:11505280 USP6NL 0.46 6.38 0.36 7.68e-10 Fibrinogen levels; CESC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg12963246 chr6:28129442 ZNF389 -0.52 -7.21 -0.4 5.96e-12 Depression; CESC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg09323728 chr8:95962352 TP53INP1 -0.39 -8.53 -0.46 1.11e-15 Type 2 diabetes; CESC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg06221963 chr1:154839813 KCNN3 -0.66 -11.27 -0.57 2.42e-24 Prostate cancer; CESC cis rs7762018 0.607 rs77972667 chr6:170130456 G/C cg19338460 chr6:170058176 WDR27 -1.05 -7.36 -0.41 2.35e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs11864453 0.713 rs6680 chr16:72146570 T/C cg16558253 chr16:72132732 DHX38 -0.55 -8.77 -0.47 2.24e-16 Fibrinogen levels; CESC cis rs1707322 0.717 rs2275086 chr1:46085879 C/G cg03146154 chr1:46216737 IPP -0.78 -10.75 -0.55 1.29e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs7618501 0.699 rs1317154 chr3:49910084 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.48 6.67 0.38 1.47e-10 Intelligence (multi-trait analysis); CESC trans rs9325144 0.534 rs1843887 chr12:38692380 T/C cg23762105 chr12:34175262 ALG10 -0.46 -6.22 -0.36 1.88e-9 Morning vs. evening chronotype; CESC cis rs3213545 0.700 rs2260445 chr12:121468863 C/A cg02403541 chr12:121454288 C12orf43 0.69 9.85 0.52 1.05e-19 Subjective well-being;Cardiovascular disease risk factors; CESC cis rs2282802 0.685 rs11750229 chr5:139559014 T/G cg26211634 chr5:139558579 C5orf32 -0.49 -7.05 -0.4 1.55e-11 Intelligence (multi-trait analysis); CESC trans rs11098499 0.708 rs10005237 chr4:120237897 T/C cg25214090 chr10:38739885 LOC399744 0.61 8.51 0.46 1.33e-15 Corneal astigmatism; CESC cis rs35110281 0.641 rs4819283 chr21:45083011 T/A cg04455712 chr21:45112962 RRP1B 0.5 7.86 0.43 9.62e-14 Mean corpuscular volume; CESC cis rs921968 0.541 rs523937 chr2:219437596 G/C cg02176678 chr2:219576539 TTLL4 0.5 8.89 0.48 9.82e-17 Mean corpuscular hemoglobin concentration; CESC cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg02079420 chr8:82753780 SNX16 -0.57 -7.89 -0.44 7.79e-14 Diastolic blood pressure; CESC cis rs2361718 0.500 rs4889818 chr17:78085228 A/G cg27427491 chr17:78079615 GAA -0.42 -6.06 -0.35 4.65e-9 Yeast infection; CESC cis rs4906332 1.000 rs2065015 chr14:103904061 G/T cg09975044 chr14:104007538 NA -0.47 -6.43 -0.37 5.95e-10 Coronary artery disease; CESC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg07701084 chr6:150067640 NUP43 0.45 6.31 0.36 1.16e-9 Lung cancer; CESC trans rs17685 0.753 rs8200 chr7:75696606 C/G cg19862616 chr7:65841803 NCRNA00174 -0.86 -12.73 -0.62 2.68e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs796364 0.951 rs7586284 chr2:201068002 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.61 5.74 0.33 2.56e-8 Schizophrenia; CESC cis rs9581857 0.579 rs77187836 chr13:27998646 C/A cg01674679 chr13:27998804 GTF3A -0.66 -5.47 -0.32 1.02e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24791880 chr19:19616215 GATAD2A 0.43 6.1 0.35 3.67e-9 Fibrinogen levels; CESC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg09658497 chr7:2847517 GNA12 -0.41 -5.78 -0.33 2.07e-8 Height; CESC cis rs10870270 1.000 rs4880263 chr10:133787629 C/T cg08754478 chr10:133766260 PPP2R2D -0.58 -7.38 -0.41 2.03e-12 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.46 6.12 0.35 3.43e-9 Personality dimensions; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg19250579 chr3:75487529 NA -0.41 -6.34 -0.36 9.6e-10 Gut microbiota (bacterial taxa); CESC cis rs6502050 0.731 rs4789730 chr17:80145983 T/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.25 -0.31 3.08e-7 Life satisfaction; CESC trans rs163030 0.902 rs367188 chr5:76737930 A/G cg26150533 chr8:82396069 FABP4 -0.39 -6.0 -0.35 6.49e-9 Caudate nucleus volume; CESC cis rs9916302 0.718 rs7219909 chr17:37706243 C/T cg15445000 chr17:37608096 MED1 0.42 6.83 0.39 5.67e-11 Glomerular filtration rate (creatinine); CESC cis rs7617773 0.563 rs62263035 chr3:48391569 C/T cg11946769 chr3:48343235 NME6 0.66 8.41 0.46 2.65e-15 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14666473 chr12:27091463 FGFR1OP2;C12orf11 -0.37 -6.49 -0.37 4.15e-10 Gambling; CESC cis rs2933343 0.679 rs789221 chr3:128591625 A/G cg24203234 chr3:128598194 ACAD9 0.39 5.22 0.31 3.62e-7 IgG glycosylation; CESC cis rs9399401 0.593 rs262117 chr6:142807093 G/A cg03128060 chr6:142623767 GPR126 0.33 5.39 0.31 1.56e-7 Chronic obstructive pulmonary disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23325670 chr19:17337031 OCEL1 -0.45 -6.11 -0.35 3.52e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs8114671 0.562 rs6087653 chr20:33522054 T/C cg06115741 chr20:33292138 TP53INP2 0.48 5.79 0.34 1.97e-8 Height; CESC trans rs7947523 0.813 rs4999940 chr11:80942337 C/T cg09378111 chr2:211036309 C2orf67 0.5 6.61 0.38 2.16e-10 Emphysema imaging phenotypes; CESC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg26314531 chr2:26401878 FAM59B -0.6 -6.79 -0.38 7.45e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs1941023 0.584 rs950803 chr11:60152563 A/T cg08716584 chr11:60157161 MS4A7 0.57 9.4 0.5 2.61e-18 Congenital heart disease (maternal effect); CESC cis rs12900413 0.687 rs6496602 chr15:90317797 A/G cg24249390 chr15:90295951 MESP1 -0.43 -5.98 -0.34 7.25e-9 Coronary artery aneurysm in Kawasaki disease; CESC cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.73 10.23 0.53 6.27e-21 Monocyte percentage of white cells; CESC trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg03929089 chr4:120376271 NA -0.77 -11.65 -0.58 1.32e-25 Coronary artery disease; CESC cis rs1707322 0.963 rs11211229 chr1:46400517 A/C cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg11987759 chr7:65425863 GUSB -0.46 -6.3 -0.36 1.26e-9 Aortic root size; CESC cis rs4843747 0.671 rs8062855 chr16:88106941 T/C cg06915872 chr16:87998081 BANP 0.44 5.24 0.31 3.36e-7 Menopause (age at onset); CESC cis rs10870270 0.830 rs10781571 chr10:133774316 G/C cg08754478 chr10:133766260 PPP2R2D -0.59 -7.61 -0.42 4.72e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs4664308 1.000 rs62175515 chr2:160909524 A/T cg03641300 chr2:160917029 PLA2R1 -0.68 -10.17 -0.53 9.82e-21 Idiopathic membranous nephropathy; CESC cis rs9527 0.590 rs726010 chr10:104841977 C/T cg04362960 chr10:104952993 NT5C2 0.44 5.6 0.33 5.24e-8 Arsenic metabolism; CESC cis rs7568458 0.663 rs699664 chr2:85780536 A/G cg02493740 chr2:85810744 VAMP5 0.6 9.39 0.5 2.97e-18 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs56804039 1.000 rs11777086 chr8:8384479 G/T cg15556689 chr8:8085844 FLJ10661 -0.5 -5.36 -0.31 1.82e-7 Cervical cancer; CESC cis rs854765 0.583 rs6502622 chr17:17834691 A/G cg09796270 chr17:17721594 SREBF1 0.42 5.95 0.34 8.24e-9 Total body bone mineral density; CESC cis rs709400 0.930 rs57447494 chr14:104034569 G/A cg12935359 chr14:103987150 CKB -0.49 -6.39 -0.37 7.55e-10 Body mass index; CESC cis rs60843830 0.964 rs62114538 chr2:256116 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.77 10.08 0.53 1.92e-20 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs7618501 1.000 rs11716575 chr3:49744890 A/G cg24308560 chr3:49941425 MST1R 0.5 6.94 0.39 3.08e-11 Intelligence (multi-trait analysis); CESC cis rs8067545 0.578 rs62066870 chr17:20063758 A/C cg13482628 chr17:19912719 NA 0.4 5.37 0.31 1.75e-7 Schizophrenia; CESC trans rs687914 0.710 rs938662 chr2:45864578 A/G cg00679716 chr14:23067188 ABHD4 0.63 6.45 0.37 5.29e-10 Diastolic blood pressure; CESC cis rs894734 0.535 rs2366143 chr12:54323256 G/A cg12374095 chr12:54320830 NA -0.41 -5.85 -0.34 1.47e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CESC cis rs8072100 1.000 rs8065437 chr17:45721653 C/T cg08085267 chr17:45401833 C17orf57 -0.43 -5.66 -0.33 3.85e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg24399712 chr22:39784796 NA -0.81 -11.1 -0.56 9.09e-24 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs36051895 0.632 rs12337481 chr9:5134599 T/G cg02405213 chr9:5042618 JAK2 -0.47 -5.85 -0.34 1.42e-8 Pediatric autoimmune diseases; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04590956 chr2:70057467 GMCL1 0.56 7.29 0.41 3.66e-12 Gut microbiota (bacterial taxa); CESC cis rs7089973 0.604 rs11196942 chr10:116596872 G/A cg03647239 chr10:116582469 FAM160B1 0.42 5.13 0.3 5.5e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg22897353 chr20:18548235 LOC388789 -0.46 -6.14 -0.35 3.04e-9 Asthma; CESC cis rs6570726 0.516 rs9376932 chr6:145729490 T/C cg23711669 chr6:146136114 FBXO30 0.51 6.48 0.37 4.35e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs910316 0.967 rs175502 chr14:75533679 A/G cg11812906 chr14:75593930 NEK9 -0.88 -15.0 -0.68 3.17e-37 Height; CESC cis rs3858526 0.959 rs10838795 chr11:5920721 A/G cg05234568 chr11:5960015 NA 0.54 6.46 0.37 4.98e-10 DNA methylation (variation); CESC cis rs1448094 0.809 rs11117103 chr12:86314431 C/T cg02569458 chr12:86230093 RASSF9 0.36 5.12 0.3 6.01e-7 Major depressive disorder; CESC cis rs7216064 0.773 rs11867618 chr17:65875587 G/A cg12091567 chr17:66097778 LOC651250 -0.9 -8.15 -0.45 1.43e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs3780486 0.505 rs1411609 chr9:33137303 C/T cg04842962 chr6:43655489 MRPS18A 0.69 10.59 0.55 4.26e-22 IgG glycosylation; CESC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg06420487 chr17:61919686 SMARCD2 0.47 5.66 0.33 3.87e-8 Height; CESC cis rs4803468 1.000 rs9304593 chr19:41942875 A/C cg09537434 chr19:41945824 ATP5SL 1.06 19.76 0.77 5e-54 Height; CESC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg07936489 chr17:37558343 FBXL20 -0.82 -12.22 -0.6 1.6e-27 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs238295 0.602 rs6053458 chr20:5510185 G/T cg24001556 chr20:5591874 RP5-1022P6.2 0.42 5.12 0.3 5.96e-7 Occipital cortical area (total cortical area interaction); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16385941 chr7:1579643 MAFK 0.47 6.07 0.35 4.33e-9 Fibrinogen levels; CESC cis rs12530845 0.623 rs77454235 chr7:135341862 T/C cg23117316 chr7:135346802 PL-5283 -0.58 -6.53 -0.37 3.25e-10 Red blood cell traits; CESC cis rs9649213 0.586 rs55648546 chr7:97960800 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.45 -6.09 -0.35 4.04e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs6430585 0.583 rs79176913 chr2:136638113 C/A cg07169764 chr2:136633963 MCM6 1.31 20.73 0.79 2.13e-57 Corneal structure; CESC cis rs1348850 0.567 rs7605609 chr2:178534942 C/G cg22681709 chr2:178499509 PDE11A -0.5 -7.37 -0.41 2.24e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs28830936 1.000 rs28444909 chr15:41953105 C/T cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.39 -5.35 -0.31 1.9e-7 Diastolic blood pressure; CESC cis rs7247513 0.964 rs4804202 chr19:12718619 T/C cg01871581 chr19:12707946 ZNF490 -0.86 -14.11 -0.66 4.12e-34 Bipolar disorder; CESC cis rs7089973 0.584 rs4752255 chr10:116576790 C/T cg03647239 chr10:116582469 FAM160B1 0.44 5.63 0.33 4.56e-8 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7959452 0.684 rs11177615 chr12:69754189 G/A cg14784868 chr12:69753453 YEATS4 0.85 13.17 0.63 8.45e-31 Blood protein levels; CESC cis rs3204270 0.759 rs77740144 chr17:79608968 G/A cg26965718 chr17:79658957 HGS -0.72 -5.13 -0.3 5.51e-7 Dental caries; CESC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg24549020 chr5:56110836 MAP3K1 0.65 7.3 0.41 3.43e-12 Type 2 diabetes; CESC cis rs561341 1.000 rs554078 chr17:30330109 A/C cg23018236 chr17:30244563 NA -0.55 -5.33 -0.31 2.1e-7 Hip circumference adjusted for BMI; CESC cis rs2735413 0.914 rs1922608 chr16:78065139 A/G cg04733911 chr16:78082701 NA -0.5 -7.9 -0.44 7.56e-14 Systolic blood pressure (alcohol consumption interaction); CESC cis rs35110281 0.641 rs9978858 chr21:45085552 A/G cg21573476 chr21:45109991 RRP1B -0.58 -8.01 -0.44 3.56e-14 Mean corpuscular volume; CESC cis rs4077515 0.901 rs34826348 chr9:139281570 A/C cg14169450 chr9:139327907 INPP5E 0.38 5.42 0.32 1.31e-7 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs8017423 0.967 rs2277515 chr14:90723000 A/G cg14092571 chr14:90743983 NA -0.55 -8.31 -0.45 5.06e-15 Mortality in heart failure; CESC cis rs397969 0.596 rs62066348 chr17:19899913 A/G cg12073167 chr17:19770448 ULK2 -0.47 -5.34 -0.31 2.04e-7 Platelet count; CESC cis rs1499614 1.000 rs1267818 chr7:66107024 C/T cg08632164 chr7:65971372 NA -0.49 -5.15 -0.3 5.03e-7 Gout; CESC cis rs11098499 0.909 rs79704848 chr4:120309351 T/A cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs372883 0.648 rs382732 chr21:30719010 A/G cg24692254 chr21:30365293 RNF160 0.53 6.68 0.38 1.43e-10 Pancreatic cancer; CESC cis rs35306767 0.807 rs61831436 chr10:837882 G/A cg20503657 chr10:835505 NA 1.08 10.24 0.53 6.05e-21 Eosinophil percentage of granulocytes; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg10927534 chr5:141392688 GNPDA1 -0.49 -6.14 -0.35 2.94e-9 Recombination measurement; CESC cis rs2354432 0.599 rs4950423 chr1:146854539 T/C cg25205988 chr1:146714368 CHD1L 1.01 8.93 0.48 7.3e-17 Mitochondrial DNA levels; CESC cis rs7208859 0.673 rs9899943 chr17:29223925 G/A cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs472109 0.748 rs4910498 chr11:9765503 A/T cg03108697 chr11:9732066 SWAP70 -0.43 -6.44 -0.37 5.71e-10 Coronary artery disease; CESC cis rs734999 0.505 rs10797437 chr1:2539006 T/C cg18854424 chr1:2615690 NA 0.3 6.01 0.35 6.23e-9 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00243897 chr12:122326549 PSMD9 0.65 7.46 0.42 1.24e-12 Gut microbiome composition (summer); CESC cis rs68170813 0.559 rs80212020 chr7:106957596 C/T cg02696742 chr7:106810147 HBP1 -0.53 -5.04 -0.3 8.64e-7 Coronary artery disease; CESC cis rs2242116 0.796 rs2290546 chr3:46965197 C/G cg02527881 chr3:46936655 PTH1R -0.5 -6.98 -0.39 2.37e-11 Birth weight; CESC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg27478167 chr7:817139 HEATR2 -0.47 -5.05 -0.3 8.35e-7 Cerebrospinal P-tau181p levels; CESC trans rs561341 0.882 rs563539 chr17:30307958 A/G cg20587970 chr11:113659929 NA -1.11 -14.04 -0.65 7.35e-34 Hip circumference adjusted for BMI; CESC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg06505273 chr16:24850292 NA -0.55 -6.58 -0.37 2.52e-10 Intelligence (multi-trait analysis); CESC cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg02079420 chr8:82753780 SNX16 -0.54 -8.28 -0.45 6.23e-15 Diastolic blood pressure; CESC cis rs61931739 0.500 rs11053208 chr12:34460029 A/G cg23762105 chr12:34175262 ALG10 -0.4 -5.1 -0.3 6.52e-7 Morning vs. evening chronotype; CESC cis rs3733585 0.806 rs7375599 chr4:9954918 C/T cg11266682 chr4:10021025 SLC2A9 0.61 12.36 0.6 5.22e-28 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6681460 0.966 rs6588215 chr1:67141949 A/G cg02459107 chr1:67143332 SGIP1 0.37 5.09 0.3 6.64e-7 Presence of antiphospholipid antibodies; CESC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg00033643 chr7:134001901 SLC35B4 0.42 5.47 0.32 1.04e-7 Mean platelet volume; CESC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg12311346 chr5:56204834 C5orf35 0.64 8.64 0.47 5.57e-16 Initial pursuit acceleration; CESC cis rs9486719 0.895 rs3734239 chr6:96996244 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -8.3 -0.45 5.39e-15 Migraine;Coronary artery disease; CESC cis rs7561273 0.586 rs11902756 chr2:24300932 A/G cg06627628 chr2:24431161 ITSN2 -0.48 -5.64 -0.33 4.35e-8 Quantitative traits; CESC cis rs7474896 0.537 rs2749586 chr10:38270214 G/C cg00409905 chr10:38381863 ZNF37A 0.45 5.06 0.3 7.68e-7 Obesity (extreme); CESC cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.4 -5.22 -0.31 3.64e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs8053891 0.756 rs12708921 chr16:71999589 G/A cg04254540 chr16:71951199 KIAA0174 -0.42 -5.3 -0.31 2.48e-7 Coronary artery disease; CESC cis rs1018836 0.847 rs35409073 chr8:91648036 G/T cg16814680 chr8:91681699 NA -0.75 -10.44 -0.54 1.34e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs11098499 0.863 rs11098532 chr4:120490726 C/A cg09307838 chr4:120376055 NA 0.92 12.65 0.61 5.39e-29 Corneal astigmatism; CESC cis rs7635838 0.892 rs12163566 chr3:11483096 T/A cg00170343 chr3:11313890 ATG7 0.43 5.85 0.34 1.46e-8 HDL cholesterol; CESC cis rs1879734 0.731 rs4927029 chr1:54169455 C/G cg23596471 chr1:54105337 GLIS1 0.35 5.47 0.32 1.03e-7 Mitral valve prolapse; CESC cis rs9790314 0.936 rs7629987 chr3:161002023 A/C cg03342759 chr3:160939853 NMD3 -0.45 -5.95 -0.34 8.66e-9 Morning vs. evening chronotype; CESC cis rs7208859 0.623 rs78071511 chr17:29128154 C/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11690935 0.851 rs6731562 chr2:172798262 T/C cg13550731 chr2:172543902 DYNC1I2 -0.72 -10.7 -0.55 1.98e-22 Schizophrenia; CESC cis rs6032067 0.526 rs2743347 chr20:43920493 T/C cg10761708 chr20:43804764 PI3 0.39 5.03 0.3 9.02e-7 Blood protein levels; CESC cis rs17253792 0.822 rs11546 chr14:56146357 G/A cg01858014 chr14:56050164 KTN1 -0.94 -7.57 -0.42 6.2800000000000005e-13 Putamen volume; CESC cis rs4253772 0.513 rs6008612 chr22:46707907 G/A cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.58 5.97 0.34 7.57e-9 LDL cholesterol;Cholesterol, total; CESC trans rs10506458 0.915 rs12424908 chr12:63402364 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.38 -18.5 -0.75 1.25e-49 Hemostatic factors and hematological phenotypes; CESC cis rs7223966 1.000 rs2665826 chr17:61944924 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.46 -5.41 -0.32 1.43e-7 Hip circumference adjusted for BMI;Body mass index; CESC trans rs10463316 0.894 rs10476980 chr5:150764157 A/G cg24389359 chr12:111284228 CCDC63 -0.33 -6.02 -0.35 5.68e-9 Metabolite levels (Pyroglutamine); CESC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg17366294 chr4:99064904 C4orf37 0.62 8.95 0.48 6.32e-17 Colonoscopy-negative controls vs population controls; CESC cis rs2573652 1.000 rs2581365 chr15:100513318 A/C cg00587665 chr15:100533223 ADAMTS17 -0.33 -5.41 -0.32 1.43e-7 Height; CESC cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg27347728 chr4:17578864 LAP3 0.43 5.12 0.3 5.92e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2559856 1.000 rs2695284 chr12:102089318 A/G cg15068132 chr12:102092402 CHPT1 0.43 5.82 0.34 1.72e-8 Blood protein levels; CESC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg13747066 chr9:74525074 C9orf85;FAM108B1 0.46 6.51 0.37 3.69e-10 Response to TNF-alpha inhibitors in rheumatoid arthritis; CESC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.52e-11 Developmental language disorder (linguistic errors); CESC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg10295955 chr4:187884368 NA 1.04 19.76 0.77 5.02e-54 Lobe attachment (rater-scored or self-reported); CESC cis rs17253792 0.822 rs17746106 chr14:56069168 C/T cg01858014 chr14:56050164 KTN1 -0.71 -6.4 -0.37 7.09e-10 Putamen volume; CESC cis rs2576037 0.796 rs2571020 chr18:44584189 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.61 -8.59 -0.47 7.46e-16 Personality dimensions; CESC cis rs959260 1.000 rs4788889 chr17:73389126 A/G cg20590849 chr17:73267439 MIF4GD -0.55 -6.36 -0.36 8.61e-10 Systemic lupus erythematosus; CESC cis rs36051895 0.664 rs3780369 chr9:5095095 A/C cg02405213 chr9:5042618 JAK2 -0.52 -6.4 -0.37 7.16e-10 Pediatric autoimmune diseases; CESC cis rs11958404 0.932 rs113264420 chr5:157437779 T/C cg05962755 chr5:157440814 NA 0.59 6.52 0.37 3.45e-10 IgG glycosylation; CESC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg03517284 chr6:25882590 NA -0.43 -5.92 -0.34 9.68e-9 Intelligence (multi-trait analysis); CESC cis rs11630290 1.000 rs72750981 chr15:63983737 A/T cg12036633 chr15:63758958 NA -0.54 -5.27 -0.31 2.87e-7 Iris characteristics; CESC cis rs34638657 0.732 rs7205534 chr16:82201618 C/T cg09439754 chr16:82129088 HSD17B2 -0.35 -6.14 -0.35 3.05e-9 Lung adenocarcinoma; CESC cis rs1062177 0.826 rs1549920 chr5:151140844 A/T cg00977110 chr5:151150581 G3BP1 0.62 6.93 0.39 3.25e-11 Preschool internalizing problems; CESC cis rs7520050 0.933 rs12045165 chr1:46256022 C/A cg03146154 chr1:46216737 IPP -0.49 -6.37 -0.36 8.44e-10 Red blood cell count;Reticulocyte count; CESC cis rs6723226 0.772 rs2366894 chr2:32713706 A/T cg02381751 chr2:32503542 YIPF4 0.82 12.2 0.6 1.79e-27 Intelligence (multi-trait analysis); CESC cis rs4853012 0.887 rs2280644 chr2:74358411 G/A cg20891558 chr2:74357851 NA 0.81 11.18 0.57 5.16e-24 Gestational age at birth (maternal effect); CESC cis rs10208940 0.920 rs35002937 chr2:68753240 T/A cg12452813 chr2:68675892 NA 0.51 5.1 0.3 6.39e-7 Urate levels in lean individuals; CESC cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg10523679 chr1:76189770 ACADM -0.65 -7.57 -0.42 6.15e-13 Blood metabolite levels;Acylcarnitine levels; CESC trans rs10489896 0.541 rs16843220 chr1:234589999 T/C cg10395685 chr11:86085715 CCDC81 -0.43 -6.15 -0.35 2.9e-9 Cognitive test performance; CESC cis rs561341 1.000 rs7210970 chr17:30262169 G/A cg13647721 chr17:30228624 UTP6 0.52 5.32 0.31 2.17e-7 Hip circumference adjusted for BMI; CESC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg22433210 chr17:43662623 NA -0.91 -10.81 -0.55 8.16e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs362296 0.698 rs3095072 chr4:3263325 G/A cg08886695 chr4:3369023 RGS12 0.39 5.19 0.3 4.19e-7 Parental longevity (mother's age at death); CESC cis rs2404602 0.692 rs12911902 chr15:77053575 T/C cg22467129 chr15:76604101 ETFA -0.34 -5.16 -0.3 4.84e-7 Blood metabolite levels; CESC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.68 0.61 4e-29 Gut microbiome composition (summer); CESC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg10691866 chr7:65817282 TPST1 -0.32 -5.26 -0.31 3.02e-7 Aortic root size; CESC trans rs10411161 0.702 rs7251571 chr19:52389057 A/G cg22319618 chr22:45562946 NUP50 -0.71 -7.13 -0.4 9.41e-12 Breast cancer; CESC cis rs2404602 0.669 rs8036703 chr15:76951040 A/G cg26408565 chr15:76604113 ETFA -0.39 -5.58 -0.32 5.95e-8 Blood metabolite levels; CESC cis rs11098499 0.730 rs12505735 chr4:120532956 G/T cg09307838 chr4:120376055 NA 0.86 11.72 0.58 7.86e-26 Corneal astigmatism; CESC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg21784768 chr11:537496 LRRC56 -0.57 -5.36 -0.31 1.85e-7 Body mass index; CESC cis rs6460942 0.630 rs62451487 chr7:12390464 G/A cg06484146 chr7:12443880 VWDE -0.65 -7.02 -0.4 1.89e-11 Coronary artery disease; CESC cis rs72829446 0.530 rs12325773 chr17:7393871 G/A cg02795151 chr17:7402630 POLR2A 0.55 5.83 0.34 1.63e-8 Androgen levels; CESC cis rs2455799 0.613 rs4685264 chr3:15858347 G/A cg16303742 chr3:15540471 COLQ -0.37 -5.69 -0.33 3.4e-8 Mean platelet volume; CESC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg05368731 chr17:41323189 NBR1 0.55 7.57 0.42 6.23e-13 Menopause (age at onset); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06225133 chr3:44690200 ZNF35 -0.56 -7.12 -0.4 1.04e-11 Ulcerative colitis; CESC cis rs6696846 0.765 rs61822567 chr1:205078725 T/C cg00857998 chr1:205179979 DSTYK 0.54 7.21 0.41 5.81e-12 Red blood cell count; CESC trans rs804280 0.518 rs34266352 chr8:11791462 G/A cg15556689 chr8:8085844 FLJ10661 0.52 6.41 0.37 6.53e-10 Myopia (pathological); CESC cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg03467027 chr4:99064603 C4orf37 0.44 5.56 0.32 6.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2180341 0.700 rs4598100 chr6:127565314 G/A cg24812749 chr6:127587940 RNF146 0.78 10.33 0.54 3.16e-21 Breast cancer; CESC cis rs9596863 0.808 rs9568879 chr13:54225170 C/T ch.13.53330881F chr13:54432880 NA 0.63 5.11 0.3 6.3e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg10128416 chr1:75198403 TYW3;CRYZ -0.47 -6.27 -0.36 1.49e-9 Resistin levels; CESC cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg11952622 chr19:58962976 ZNF324B 0.47 6.49 0.37 4.27e-10 Uric acid clearance; CESC cis rs7833790 0.553 rs9693128 chr8:82706128 A/G cg06027949 chr8:82754900 SNX16 -0.64 -8.49 -0.46 1.54e-15 Diastolic blood pressure; CESC cis rs9303401 0.614 rs68100606 chr17:56500898 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.95 11.7 0.58 9.24e-26 Cognitive test performance; CESC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg20295408 chr7:1910781 MAD1L1 -0.41 -5.27 -0.31 2.82e-7 Bipolar disorder and schizophrenia; CESC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.09 0.6 4.15e-27 Alzheimer's disease; CESC cis rs4595586 0.545 rs1303887 chr12:39366523 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.51 0.42 9.32e-13 Morning vs. evening chronotype; CESC cis rs9925964 0.933 rs56314408 chr16:31117389 T/C cg02466173 chr16:30829666 NA -0.32 -5.19 -0.3 4.18e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2295499 0.754 rs2285082 chr4:2627698 G/A cg08330972 chr4:2403930 ZFYVE28 -0.33 -5.4 -0.31 1.51e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg16325326 chr1:53192061 ZYG11B -0.88 -14.98 -0.68 3.69e-37 Monocyte count; CESC cis rs12477438 0.520 rs2171359 chr2:99795360 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.86 15.21 0.68 5.36e-38 Chronic sinus infection; CESC cis rs9611565 0.506 rs7364221 chr22:41650190 C/A cg03806693 chr22:41940476 POLR3H -0.72 -7.94 -0.44 5.69e-14 Vitiligo; CESC cis rs80130819 0.688 rs10783232 chr12:48583491 A/G cg05342945 chr12:48394962 COL2A1 -0.51 -6.02 -0.35 5.77e-9 Prostate cancer; CESC cis rs2404602 0.735 rs2461870 chr15:76813920 T/G cg23625390 chr15:77176239 SCAPER -0.4 -5.69 -0.33 3.31e-8 Blood metabolite levels; CESC cis rs2573652 1.000 rs2573625 chr15:100513158 A/G cg09939229 chr15:100514479 ADAMTS17 0.36 5.22 0.31 3.62e-7 Height; CESC cis rs861020 1.000 rs12134698 chr1:209987801 C/A cg05527609 chr1:210001259 C1orf107 -1.07 -13.45 -0.64 8.66e-32 Orofacial clefts; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01768981 chr5:54529226 CCNO -0.45 -6.24 -0.36 1.68e-9 Fibrinogen levels; CESC cis rs4555082 0.915 rs28594491 chr14:105758018 G/A cg06808227 chr14:105710500 BRF1 -0.55 -6.3 -0.36 1.22e-9 Mean platelet volume;Platelet distribution width; CESC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg19163074 chr7:65112434 INTS4L2 0.41 5.27 0.31 2.89e-7 Aortic root size; CESC cis rs10492096 0.945 rs1045546 chr12:6567907 C/T cg13857086 chr12:6580257 VAMP1 0.63 5.98 0.34 7.09e-9 Hip geometry; CESC cis rs10129255 1.000 rs4612959 chr14:107175298 A/G cg23076370 chr14:107095027 NA -0.44 -5.42 -0.32 1.36e-7 Kawasaki disease; CESC cis rs9486719 0.901 rs760619 chr6:96857431 A/G cg18709589 chr6:96969512 KIAA0776 0.53 5.54 0.32 7.29e-8 Migraine;Coronary artery disease; CESC cis rs854765 0.927 rs4925138 chr17:17992793 T/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.44 -5.57 -0.32 6.19e-8 Total body bone mineral density; CESC cis rs9467711 0.538 rs35934643 chr6:26355094 G/A cg12826209 chr6:26865740 GUSBL1 0.62 5.31 0.31 2.36e-7 Autism spectrum disorder or schizophrenia; CESC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg13722127 chr7:150037890 RARRES2 0.36 5.12 0.3 5.88e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs2463822 0.925 rs72923272 chr11:62166832 G/A cg06239285 chr11:62104954 ASRGL1 -1.05 -9.05 -0.49 3.22e-17 Chronic obstructive pulmonary disease-related biomarkers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21075560 chr15:43663139 ZSCAN29;TUBGCP4 0.59 6.72 0.38 1.11e-10 Gut microbiome composition (summer); CESC cis rs12549902 1.000 rs12550613 chr8:41510260 G/C cg00088007 chr8:41504566 NKX6-3 0.29 5.05 0.3 8.34e-7 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; CESC cis rs2522056 1.000 rs2706393 chr5:131796067 G/A cg24060327 chr5:131705240 SLC22A5 0.59 6.63 0.38 1.85e-10 Lymphocyte counts;Fibrinogen; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01302669 chr3:49824110 IP6K1 -0.46 -6.26 -0.36 1.55e-9 Height; CESC cis rs897984 0.770 rs12930657 chr16:30931968 C/T cg02466173 chr16:30829666 NA 0.49 8.46 0.46 1.82e-15 Dementia with Lewy bodies; CESC cis rs11252926 0.931 rs12358336 chr10:566981 A/T cg18196295 chr10:418757 DIP2C -0.49 -5.74 -0.33 2.62e-8 Psychosis in Alzheimer's disease; CESC cis rs2463822 1.000 rs2513052 chr11:62108248 C/G cg06239285 chr11:62104954 ASRGL1 0.87 8.77 0.47 2.28e-16 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9303401 0.614 rs62084387 chr17:57148027 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.97 11.01 0.56 1.82e-23 Cognitive test performance; CESC cis rs9768139 0.566 rs729099 chr7:158114152 C/T cg25566285 chr7:158114605 PTPRN2 0.52 8.26 0.45 7.04e-15 Calcium levels; CESC cis rs5763662 1.000 rs13056990 chr22:30534161 G/A cg21388335 chr22:29999516 NF2 -0.74 -5.03 -0.3 9.22e-7 LDL cholesterol levels;LDL cholesterol; CESC cis rs4253772 0.530 rs9615958 chr22:46751122 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.62 5.16 0.3 4.87e-7 LDL cholesterol;Cholesterol, total; CESC cis rs1707322 0.717 rs3014237 chr1:46090252 A/G cg03146154 chr1:46216737 IPP -0.78 -10.38 -0.54 2.03e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs112790992 1 rs112790992 chr14:105758217 A/C cg06808227 chr14:105710500 BRF1 -0.54 -6.78 -0.38 7.72e-11 Platelet count; CESC cis rs2860975 1.000 rs2860974 chr10:96779866 A/G cg09036531 chr10:96991505 NA -0.41 -5.62 -0.33 4.74e-8 Immune response to smallpox vaccine (IL-6); CESC cis rs4253772 0.638 rs6007845 chr22:46718417 A/T cg10231785 chr22:46692440 CN5H6.4;GTSE1 -0.56 -6.21 -0.36 2.08e-9 LDL cholesterol;Cholesterol, total; CESC cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.46 6.08 0.35 4.16e-9 Eosinophil percentage of white cells; CESC cis rs6088580 0.634 rs4277599 chr20:33008905 A/G cg08999081 chr20:33150536 PIGU -0.59 -10.37 -0.54 2.31e-21 Glomerular filtration rate (creatinine); CESC cis rs10276381 0.901 rs73300638 chr7:28187344 A/C cg23620719 chr7:28220237 JAZF1 0.74 7.66 0.43 3.44e-13 Crohn's disease; CESC cis rs7659604 0.702 rs58649165 chr4:122693752 C/A cg20573242 chr4:122745356 CCNA2 0.43 5.35 0.31 1.86e-7 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17524151 chr16:475494 RAB11FIP3 -0.54 -7.27 -0.41 4.07e-12 Gut microbiota (bacterial taxa); CESC cis rs9457247 0.663 rs9295384 chr6:167448113 T/A cg25258033 chr6:167368657 RNASET2 0.36 5.24 0.31 3.33e-7 Crohn's disease; CESC cis rs7618501 1.000 rs6802890 chr3:49832261 A/G cg24308560 chr3:49941425 MST1R -0.52 -7.11 -0.4 1.08e-11 Intelligence (multi-trait analysis); CESC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg10691866 chr7:65817282 TPST1 -0.34 -5.62 -0.33 4.93e-8 Aortic root size; CESC cis rs1190552 0.846 rs1044503 chr14:102965996 A/G cg18135206 chr14:102964638 TECPR2 0.42 5.29 0.31 2.52e-7 Blood protein levels; CESC cis rs1790761 0.587 rs4930431 chr11:67294308 C/T cg14500267 chr11:67383377 NA -0.33 -5.58 -0.32 5.86e-8 Mean corpuscular volume; CESC cis rs2486288 0.539 rs2433601 chr15:45716425 T/C cg21132104 chr15:45694354 SPATA5L1 0.66 8.55 0.47 9.63e-16 Glomerular filtration rate; CESC cis rs2243480 1.000 rs59794892 chr7:65415873 G/A cg12463550 chr7:65579703 CRCP 0.7 5.61 0.33 5e-8 Diabetic kidney disease; CESC cis rs1008375 0.931 rs10939734 chr4:17570709 C/T cg27347728 chr4:17578864 LAP3 0.43 5.14 0.3 5.22e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8062405 0.755 rs7186573 chr16:28587389 T/C cg01378222 chr16:28622494 SULT1A1 0.31 5.32 0.31 2.25e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7264396 0.635 rs6060719 chr20:34546013 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.81 -11.06 -0.56 1.23e-23 Total cholesterol levels; CESC cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg21573476 chr21:45109991 RRP1B -0.57 -8.24 -0.45 7.86e-15 Mean corpuscular volume; CESC cis rs30380 0.587 rs151940 chr5:96147777 T/C cg16492584 chr5:96139282 ERAP1 -0.51 -7.02 -0.4 1.86e-11 Cerebrospinal fluid biomarker levels; CESC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 10.27 0.53 4.67e-21 Personality dimensions; CESC cis rs12477438 0.508 rs2516832 chr2:99771268 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.81 0.7 4.17e-40 Chronic sinus infection; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13393195 chr12:113659153 TPCN1;IQCD 0.55 7.19 0.4 6.65e-12 Gut microbiota (bacterial taxa); CESC cis rs6748734 1.000 rs4675874 chr2:241819796 A/G cg04034577 chr2:241836375 C2orf54 0.51 9.07 0.49 2.67e-17 Urinary metabolites; CESC trans rs9467711 0.606 rs9379859 chr6:26369549 C/T cg06606381 chr12:133084897 FBRSL1 -0.76 -6.86 -0.39 4.71e-11 Autism spectrum disorder or schizophrenia; CESC cis rs6089829 0.888 rs4809468 chr20:61673566 T/C cg03213289 chr20:61660250 NA 0.35 5.23 0.31 3.47e-7 Prostate cancer (SNP x SNP interaction); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg13132016 chr14:58893740 KIAA0586;TIMM9 -0.47 -6.48 -0.37 4.37e-10 Gut microbiota (bacterial taxa); CESC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg23978390 chr7:1156363 C7orf50 0.6 8.45 0.46 1.91e-15 Longevity;Endometriosis; CESC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg16680214 chr1:154839983 KCNN3 0.43 6.71 0.38 1.15e-10 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17404403 chr4:110737017 GAR1 0.65 7.6 0.42 5.13e-13 Gut microbiome composition (summer); CESC cis rs60154123 0.505 rs2206043 chr1:210042983 G/A cg25204440 chr1:209979598 IRF6 0.61 5.95 0.34 8.43e-9 Coronary artery disease; CESC cis rs736408 0.677 rs678 chr3:52820981 A/T cg17372223 chr3:52568218 NT5DC2 0.38 5.2 0.3 4.05e-7 Bipolar disorder; CESC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.29 0.57 2.21e-24 Alzheimer's disease; CESC cis rs722599 0.683 rs2302834 chr14:75279395 T/A cg08847533 chr14:75593920 NEK9 0.49 5.97 0.34 7.47e-9 IgG glycosylation; CESC cis rs1008375 1.000 rs6449323 chr4:17683916 A/T cg16339924 chr4:17578868 LAP3 0.54 6.7 0.38 1.27e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1697139 0.583 rs11739603 chr5:66540687 C/T cg11553311 chr5:66541588 NA 0.38 5.37 0.31 1.75e-7 Breast cancer; CESC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg09658497 chr7:2847517 GNA12 -0.42 -6.01 -0.35 6.1e-9 Height; CESC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg26939375 chr7:64535504 NA -0.67 -9.59 -0.51 6.8e-19 Calcium levels; CESC cis rs2979489 0.891 rs6982511 chr8:30355513 G/T cg26383811 chr8:30366931 RBPMS -0.79 -10.19 -0.53 8.89e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs7149337 0.836 rs34953083 chr14:51672432 A/G cg23942311 chr14:51606299 NA 0.43 7.19 0.4 6.59e-12 Cancer; CESC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.47 -0.32 1.02e-7 Total body bone mineral density; CESC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg02935154 chr7:12443704 VWDE -0.6 -6.82 -0.39 6.02e-11 Coronary artery disease; CESC cis rs3106136 0.967 rs12645192 chr4:95181525 C/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.73 -0.38 1.07e-10 Capecitabine sensitivity; CESC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg03762994 chr17:6899332 ALOX12 0.4 7.14 0.4 8.85e-12 Tonsillectomy; CESC cis rs4423214 0.592 rs11234027 chr11:71234107 G/A cg05163923 chr11:71159392 DHCR7 -0.57 -6.03 -0.35 5.49e-9 Vitamin D levels; CESC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg07092213 chr7:1199455 ZFAND2A -0.39 -5.35 -0.31 1.9e-7 Longevity;Endometriosis; CESC cis rs826838 1.000 rs1393537 chr12:38920961 C/T cg13010199 chr12:38710504 ALG10B 0.6 8.42 0.46 2.34e-15 Heart rate; CESC cis rs11676348 0.712 rs12694426 chr2:218942351 T/G cg00012203 chr2:219082015 ARPC2 -0.45 -5.52 -0.32 8.2e-8 Ulcerative colitis; CESC cis rs826838 0.935 rs4583043 chr12:38645147 T/G cg13010199 chr12:38710504 ALG10B 0.59 8.3 0.45 5.22e-15 Heart rate; CESC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg16325326 chr1:53192061 ZYG11B 0.82 12.7 0.61 3.6e-29 Monocyte count; CESC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.71 0.38 1.2e-10 Bipolar disorder; CESC cis rs7833986 0.501 rs2667999 chr8:56950474 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.55 0.42 6.89e-13 Height; CESC cis rs7914558 0.966 rs11191438 chr10:104637864 C/G cg15744005 chr10:104629667 AS3MT -0.34 -5.57 -0.32 6.14e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12050794 0.671 rs7179427 chr15:72516821 G/A cg16672083 chr15:72433130 SENP8 0.46 6.89 0.39 4.06e-11 Metabolite levels (HVA/MHPG ratio); CESC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg13866156 chr1:1669148 SLC35E2 -0.51 -6.82 -0.39 6.21e-11 Body mass index; CESC cis rs921968 0.643 rs579610 chr2:219327582 C/A cg02176678 chr2:219576539 TTLL4 0.43 7.66 0.43 3.53e-13 Mean corpuscular hemoglobin concentration; CESC cis rs921968 0.541 rs532425 chr2:219434194 A/G cg02176678 chr2:219576539 TTLL4 0.5 8.89 0.48 9.82e-17 Mean corpuscular hemoglobin concentration; CESC cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg02487422 chr3:49467188 NICN1 0.45 5.67 0.33 3.69e-8 Parkinson's disease; CESC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg19346786 chr7:2764209 NA -0.5 -7.44 -0.42 1.44e-12 Height; CESC cis rs7847628 0.551 rs10818476 chr9:123572038 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 7.75 0.43 1.92e-13 Birth weight; CESC trans rs9467711 0.790 rs13195402 chr6:26463575 G/T cg06606381 chr12:133084897 FBRSL1 -1.06 -8.04 -0.44 3.05e-14 Autism spectrum disorder or schizophrenia; CESC trans rs1814175 0.616 rs10769644 chr11:49987676 C/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.26 -0.36 1.53e-9 Height; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg19022476 chr8:145745884 LRRC14 -0.46 -6.49 -0.37 4.16e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12251659 chr12:122018385 KDM2B 0.63 7.02 0.4 1.81e-11 Gut microbiome composition (summer); CESC cis rs10463316 0.894 rs7718085 chr5:150742957 G/C cg03212797 chr5:150827313 SLC36A1 -0.47 -6.0 -0.35 6.43e-9 Metabolite levels (Pyroglutamine); CESC cis rs67460515 0.563 rs34630898 chr3:160827038 A/G cg03342759 chr3:160939853 NMD3 -0.47 -6.04 -0.35 5.13e-9 Parkinson's disease; CESC cis rs1800795 0.901 rs2069833 chr7:22767664 C/T cg05472934 chr7:22766657 IL6 0.84 11.19 0.57 4.68e-24 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CESC cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg23711669 chr6:146136114 FBXO30 -1.04 -14.66 -0.67 5.06e-36 Lobe attachment (rater-scored or self-reported); CESC cis rs2637266 0.739 rs2579737 chr10:78422546 G/T cg18941641 chr10:78392320 NA 0.39 7.28 0.41 3.87e-12 Pulmonary function; CESC cis rs7084402 0.967 rs1658424 chr10:60331588 G/A cg07615347 chr10:60278583 BICC1 0.59 9.15 0.49 1.57e-17 Refractive error; CESC cis rs6674970 0.518 rs6587552 chr1:151018861 C/T cg03258749 chr1:151040405 MLLT11 0.43 5.95 0.34 8.43e-9 Childhood ear infection; CESC cis rs4253772 0.550 rs9615949 chr22:46722531 C/T cg00784671 chr22:46762841 CELSR1 -0.54 -5.92 -0.34 1.01e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7116495 0.609 rs4245463 chr11:71743213 C/A cg10381502 chr11:71823885 C11orf51 -1.22 -7.42 -0.41 1.64e-12 Severe influenza A (H1N1) infection; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18501264 chr19:33555827 RHPN2 0.47 6.23 0.36 1.82e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs938554 0.784 rs4481233 chr4:9956079 A/G cg00071950 chr4:10020882 SLC2A9 0.6 6.39 0.37 7.46e-10 Blood metabolite levels; CESC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg11764359 chr7:65958608 NA -0.78 -11.43 -0.57 7.35e-25 Aortic root size; CESC cis rs12477438 0.798 rs6712338 chr2:99585457 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.69 0.43 2.88e-13 Prudent dietary pattern; CESC trans rs60843830 1.000 rs59937473 chr2:271797 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 8.27 0.45 6.64e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs34779708 0.771 rs12098283 chr10:35478115 G/T cg03585969 chr10:35415529 CREM 0.72 9.08 0.49 2.61e-17 Inflammatory bowel disease;Crohn's disease; CESC cis rs4595586 0.545 rs7976609 chr12:39394317 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.42 3.96e-13 Morning vs. evening chronotype; CESC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg18016565 chr1:150552671 MCL1 -0.34 -5.69 -0.33 3.43e-8 Lymphocyte counts; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08135278 chr1:226070709 TMEM63A 0.65 7.28 0.41 3.82e-12 Gut microbiome composition (summer); CESC cis rs12541635 0.902 rs62525696 chr8:106968703 C/T cg10147462 chr8:107024639 NA 0.38 5.21 0.3 3.83e-7 Age of smoking initiation; CESC cis rs4253772 0.591 rs9615938 chr22:46689468 G/A cg18190219 chr22:46762943 CELSR1 -0.59 -5.45 -0.32 1.14e-7 LDL cholesterol;Cholesterol, total; CESC cis rs7727544 0.735 rs274557 chr5:131721204 T/C cg07395648 chr5:131743802 NA 0.48 6.48 0.37 4.48e-10 Blood metabolite levels; CESC cis rs709400 0.628 rs1989565 chr14:103862193 G/A cg12935359 chr14:103987150 CKB 0.51 7.83 0.43 1.17e-13 Body mass index; CESC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg18876405 chr7:65276391 NA 0.51 6.84 0.39 5.61e-11 Aortic root size; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg00727112 chr4:159690372 FNIP2 -0.51 -6.17 -0.35 2.6e-9 Gut microbiota (bacterial taxa); CESC cis rs763121 0.819 rs5757161 chr22:38990662 G/A cg06022373 chr22:39101656 GTPBP1 0.89 15.08 0.68 1.66e-37 Menopause (age at onset); CESC cis rs854765 0.647 rs721669 chr17:18005073 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.11 0.35 3.58e-9 Total body bone mineral density; CESC cis rs9457247 0.935 rs1794697 chr6:167395410 C/T cg25258033 chr6:167368657 RNASET2 0.4 5.95 0.34 8.39e-9 Crohn's disease; CESC cis rs9322193 0.566 rs4869768 chr6:150245203 A/G cg01145232 chr6:150245071 RAET1G -0.57 -7.19 -0.4 6.69e-12 Lung cancer; CESC trans rs61931739 0.500 rs7312938 chr12:34378708 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.21 0.36 2.01e-9 Morning vs. evening chronotype; CESC trans rs9650657 0.504 rs10093053 chr8:11037187 T/C cg06636001 chr8:8085503 FLJ10661 -0.51 -6.58 -0.37 2.48e-10 Neuroticism; CESC cis rs2074585 0.679 rs2601195 chr15:90938232 G/A cg10434728 chr15:90938212 IQGAP1 0.44 8.23 0.45 8.55e-15 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs3105593 1.000 rs8023644 chr15:50937123 C/T cg08437265 chr15:50716283 USP8 0.41 5.41 0.32 1.41e-7 QT interval; CESC cis rs734999 0.572 rs3748816 chr1:2526746 A/G cg18854424 chr1:2615690 NA 0.27 5.43 0.32 1.27e-7 Ulcerative colitis; CESC cis rs35110281 0.591 rs162369 chr21:44931965 G/A cg01579765 chr21:45077557 HSF2BP -0.49 -8.43 -0.46 2.25e-15 Mean corpuscular volume; CESC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg06873352 chr17:61820015 STRADA 0.72 12.61 0.61 7.18e-29 Prudent dietary pattern; CESC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg23048001 chr7:2026167 MAD1L1 0.41 5.25 0.31 3.07e-7 Bipolar disorder and schizophrenia; CESC cis rs12541635 0.966 rs7819327 chr8:106986003 A/C cg10147462 chr8:107024639 NA 0.41 5.62 0.33 4.73e-8 Age of smoking initiation; CESC cis rs2637266 1.000 rs2395390 chr10:78357734 C/G cg18941641 chr10:78392320 NA 0.42 7.73 0.43 2.28e-13 Pulmonary function; CESC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -5.06 -0.3 7.8e-7 Alzheimer's disease (late onset); CESC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Depression; CESC cis rs5769765 0.955 rs2295406 chr22:50260169 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.45 5.26 0.31 3.05e-7 Schizophrenia; CESC cis rs7546094 1.000 rs6669096 chr1:113132361 T/C cg22162597 chr1:113214053 CAPZA1 0.38 5.86 0.34 1.35e-8 Platelet distribution width; CESC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.51e-24 Menopause (age at onset); CESC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 13.15 0.63 1e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.58 8.4 0.46 2.71e-15 Intelligence (multi-trait analysis); CESC cis rs12220238 1.000 rs10824129 chr10:76008855 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.61 6.02 0.35 5.8e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs2742234 0.541 rs11238479 chr10:43717423 C/T cg15436174 chr10:43711423 RASGEF1A 0.47 5.58 0.32 5.81e-8 Hirschsprung disease; CESC cis rs727505 1.000 rs59294613 chr7:124554267 C/A cg23710748 chr7:124431027 NA -0.39 -6.33 -0.36 1.05e-9 Lewy body disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06505107 chr7:1177883 C7orf50 -0.46 -6.15 -0.35 2.89e-9 Fibrinogen levels; CESC cis rs17253792 0.915 rs28663681 chr14:56178820 A/T cg01858014 chr14:56050164 KTN1 -0.94 -7.27 -0.41 4.03e-12 Putamen volume; CESC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg02569458 chr12:86230093 RASSF9 0.48 7.26 0.41 4.17e-12 Major depressive disorder; CESC cis rs7845219 0.544 rs7001535 chr8:95921090 C/G cg16049864 chr8:95962084 TP53INP1 -0.49 -7.22 -0.41 5.48e-12 Type 2 diabetes; CESC cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg12927641 chr6:109611667 NA -0.44 -6.83 -0.39 5.89e-11 Reticulocyte fraction of red cells; CESC cis rs3008870 0.583 rs3008892 chr1:67373558 A/T cg08660285 chr1:67390436 MIER1;WDR78 1.0 11.28 0.57 2.4e-24 Lymphocyte percentage of white cells; CESC cis rs2066819 1.000 rs77032009 chr12:56679971 A/G cg26714650 chr12:56694279 CS -1.52 -10.39 -0.54 1.95e-21 Psoriasis vulgaris; CESC cis rs2836633 0.929 rs2836602 chr21:40039169 A/T cg05519781 chr21:40033154 ERG -0.75 -13.05 -0.63 2.17e-30 Coronary artery disease; CESC cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.79 -0.38 7.4e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg17219203 chr10:38645113 HSD17B7P2 -0.46 -5.73 -0.33 2.78e-8 Breast cancer; CESC cis rs9323205 0.861 rs55763867 chr14:51608567 G/A cg23942311 chr14:51606299 NA -0.46 -6.1 -0.35 3.81e-9 Cancer; CESC cis rs28489187 0.683 rs6576764 chr1:85866411 A/T cg16011679 chr1:85725395 C1orf52 -0.44 -5.32 -0.31 2.22e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC trans rs561341 0.769 rs7217004 chr17:30178092 A/G cg20587970 chr11:113659929 NA 1.02 10.75 0.55 1.29e-22 Hip circumference adjusted for BMI; CESC cis rs4925386 1.000 rs6089351 chr20:60916153 G/A cg24112000 chr20:60950667 NA 0.51 7.53 0.42 8.09e-13 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs9300255 0.537 rs1716182 chr12:123686127 A/C cg00376283 chr12:123451042 ABCB9 0.71 8.92 0.48 7.69e-17 Neutrophil percentage of white cells; CESC cis rs9287719 0.934 rs6432110 chr2:10738018 T/A cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs7524258 0.868 rs4908448 chr1:7269283 A/G cg07173049 chr1:7289937 CAMTA1 -0.32 -5.06 -0.3 7.93e-7 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs12142240 0.659 rs17361873 chr1:46832686 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.24 0.36 1.74e-9 Menopause (age at onset); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23593986 chr20:33577678 MIR499;MYH7B -0.46 -6.62 -0.38 1.93e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs4969178 1.000 rs4969178 chr17:76388202 C/T cg05887092 chr17:76393375 PGS1 -0.56 -8.82 -0.48 1.57e-16 HDL cholesterol levels; CESC cis rs56775891 1.000 rs56775891 chr18:77575613 C/T cg13263691 chr18:77568018 NA 0.52 7.54 0.42 7.43e-13 Schizophrenia; CESC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg17724175 chr1:150552817 MCL1 0.44 7.21 0.41 5.8e-12 Tonsillectomy; CESC cis rs9896933 0.832 rs75552659 chr17:80804630 G/A cg15664640 chr17:80829946 TBCD -0.54 -5.81 -0.34 1.76e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg02569458 chr12:86230093 RASSF9 -0.42 -6.44 -0.37 5.67e-10 Major depressive disorder; CESC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg11764359 chr7:65958608 NA 0.94 14.96 0.68 4.3e-37 Aortic root size; CESC cis rs1691799 0.867 rs2172881 chr12:66766039 C/G cg16791601 chr12:66731901 HELB -0.76 -13.45 -0.64 8.78e-32 White blood cell count (basophil); CESC cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg13798912 chr7:905769 UNC84A -0.57 -5.55 -0.32 6.82e-8 Cerebrospinal P-tau181p levels; CESC cis rs2832191 0.791 rs2832186 chr21:30484151 A/C cg24692254 chr21:30365293 RNF160 -0.78 -12.16 -0.6 2.57e-27 Dental caries; CESC cis rs941873 0.868 rs7898 chr10:81114959 C/T cg08514558 chr10:81106712 PPIF 0.33 5.8 0.34 1.85e-8 Height; CESC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg18135555 chr8:22132992 PIWIL2 0.25 5.35 0.31 1.93e-7 Hypertriglyceridemia; CESC cis rs7208859 0.573 rs55661352 chr17:29045628 A/G cg14008862 chr17:28927542 LRRC37B2 0.67 5.17 0.3 4.7e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs6433857 0.536 rs7557023 chr2:181350474 G/A cg23363182 chr2:181467187 NA -0.41 -5.94 -0.34 9.11e-9 Body mass index; CESC cis rs12497850 0.865 rs7649458 chr3:48920127 C/T cg06212747 chr3:49208901 KLHDC8B 0.65 8.98 0.48 5.35e-17 Parkinson's disease; CESC cis rs10779751 1.000 rs2024627 chr1:11298790 T/C cg08854313 chr1:11322531 MTOR 0.79 10.78 0.55 1.06e-22 Body mass index; CESC cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg25517755 chr10:38738941 LOC399744 -0.48 -6.22 -0.36 1.95e-9 Extrinsic epigenetic age acceleration; CESC cis rs11098499 0.954 rs6857105 chr4:120222298 C/G cg24375607 chr4:120327624 NA 0.45 5.57 0.32 6.19e-8 Corneal astigmatism; CESC cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg05347473 chr6:146136440 FBXO30 0.58 7.38 0.41 2.1e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs60154123 0.730 rs12403947 chr1:210456524 A/G cg21951975 chr1:209979733 IRF6 -0.48 -6.23 -0.36 1.78e-9 Coronary artery disease; CESC cis rs9611565 0.512 rs45500192 chr22:42177899 A/G cg03806693 chr22:41940476 POLR3H -1.18 -13.79 -0.65 5.81e-33 Vitiligo; CESC cis rs7605827 0.681 rs63106161 chr2:15537726 T/C cg19274914 chr2:15703543 NA 0.36 6.55 0.37 2.91e-10 Educational attainment (years of education); CESC cis rs300703 0.719 rs423314 chr2:195372 A/G cg21211680 chr2:198530 NA 1.07 12.54 0.61 1.25e-28 Blood protein levels; CESC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Tonsillectomy; CESC trans rs7246760 1.000 rs112124298 chr19:9923154 T/C cg02900749 chr2:68251473 NA -0.74 -6.84 -0.39 5.62e-11 Pursuit maintenance gain; CESC cis rs4654899 0.802 rs6685306 chr1:21219050 C/T cg05370193 chr1:21551575 ECE1 0.4 5.72 0.33 2.81e-8 Superior frontal gyrus grey matter volume; CESC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg19346786 chr7:2764209 NA -0.51 -7.34 -0.41 2.69e-12 Height; CESC cis rs12220238 0.908 rs11000937 chr10:75998785 A/C cg19889307 chr10:75911429 ADK;AP3M1 0.61 5.98 0.35 7.02e-9 Soluble interleukin-2 receptor subunit alpha; CESC cis rs12368653 1.000 rs12371356 chr12:58135420 T/C cg00677455 chr12:58241039 CTDSP2 -0.42 -5.51 -0.32 8.7e-8 Multiple sclerosis; CESC cis rs9633740 1.000 rs7922621 chr10:82251544 C/A cg00277334 chr10:82204260 NA -0.57 -5.73 -0.33 2.69e-8 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00309178 chr1:242011396 EXO1 0.57 6.19 0.36 2.27e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15034757 chr3:186617939 NA -0.57 -6.42 -0.37 6.18e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26335430 chr17:73780571 UNK -0.59 -7.05 -0.4 1.56e-11 Gut microbiome composition (summer); CESC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg06873352 chr17:61820015 STRADA 0.47 6.85 0.39 5.3e-11 Height; CESC cis rs798554 0.704 rs798512 chr7:2782592 C/G cg13628971 chr7:2884303 GNA12 0.42 5.5 0.32 9.03e-8 Height; CESC cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg06636001 chr8:8085503 FLJ10661 0.44 5.56 0.32 6.64e-8 Mood instability; CESC cis rs72781680 0.848 rs55725028 chr2:23966447 A/G cg08917208 chr2:24149416 ATAD2B 1.09 9.91 0.52 6.96e-20 Lymphocyte counts; CESC cis rs6502050 0.635 rs11867440 chr17:80147185 A/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.56e-7 Life satisfaction; CESC cis rs11785400 1.000 rs7459630 chr8:143738585 A/C cg24634471 chr8:143751801 JRK 0.47 6.25 0.36 1.66e-9 Schizophrenia; CESC cis rs9902453 0.619 rs2244585 chr17:28072176 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.22 -0.53 6.81e-21 Coffee consumption (cups per day); CESC cis rs6963495 0.745 rs818620 chr7:105172685 G/C cg02135003 chr7:105160482 PUS7 -0.43 -5.88 -0.34 1.24e-8 Bipolar disorder (body mass index interaction); CESC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg01416388 chr22:39784598 NA -0.62 -7.29 -0.41 3.5e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7246657 0.943 rs2081096 chr19:37964700 G/A cg23950597 chr19:37808831 NA -0.54 -5.93 -0.34 9.47e-9 Coronary artery calcification; CESC cis rs11920090 0.720 rs5394 chr3:170744893 G/A cg09710316 chr3:170744871 SLC2A2 0.48 5.38 0.31 1.62e-7 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18803079 chr1:64014643 EFCAB7;DLEU2L -0.7 -8.0 -0.44 3.88e-14 Gut microbiome composition (summer); CESC cis rs72781680 1.000 rs72796357 chr2:24160131 A/G cg08917208 chr2:24149416 ATAD2B 0.94 8.52 0.46 1.26e-15 Lymphocyte counts; CESC cis rs910316 1.000 rs12435391 chr14:75601737 A/G cg11812906 chr14:75593930 NEK9 0.89 15.29 0.68 2.96e-38 Height; CESC cis rs644799 0.526 rs542509 chr11:95641602 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.55 7.41 0.41 1.69e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1008375 1.000 rs4642241 chr4:17617111 T/C cg02297831 chr4:17616191 MED28 0.53 6.73 0.38 1.04e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs17376456 0.825 rs13361613 chr5:93272176 C/T cg25358565 chr5:93447407 FAM172A 1.12 10.4 0.54 1.88e-21 Diabetic retinopathy; CESC cis rs12136530 0.625 rs12726614 chr1:19730957 G/C cg01832549 chr1:19774989 CAPZB -0.44 -6.25 -0.36 1.59e-9 Lead levels in blood; CESC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.69 -7.83 -0.43 1.19e-13 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05863534 chr17:34948351 DHRS11 0.58 6.56 0.37 2.77e-10 Gut microbiome composition (summer); CESC cis rs686320 1.000 rs72643572 chr11:65250967 A/G cg21890820 chr11:65308645 LTBP3 0.48 5.25 0.31 3.15e-7 Hip circumference adjusted for BMI; CESC cis rs7917772 0.503 rs61871067 chr10:104295382 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.58 7.05 0.4 1.6e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9837602 0.872 rs1489816 chr3:99769088 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.49 -6.91 -0.39 3.51e-11 Breast cancer; CESC cis rs896854 0.517 rs2013597 chr8:95951807 G/A cg23172400 chr8:95962367 TP53INP1 -0.41 -7.29 -0.41 3.51e-12 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05424782 chr22:42017079 XRCC6;PPPDE2 -0.7 -7.55 -0.42 6.88e-13 Gut microbiome composition (summer); CESC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg03240473 chr21:43526662 UMODL1;C21orf128 -0.54 -7.36 -0.41 2.25e-12 IgG glycosylation; CESC cis rs7560272 0.513 rs7558546 chr2:73937732 A/T cg20560298 chr2:73613845 ALMS1 0.4 5.57 0.32 6.27e-8 Schizophrenia; CESC cis rs11792861 0.781 rs11789252 chr9:111762010 A/T cg13535736 chr9:111863775 C9orf5 -0.46 -6.04 -0.35 5.1e-9 Menarche (age at onset); CESC cis rs11098499 0.954 rs10005644 chr4:120298477 T/C cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs1580019 0.539 rs11769109 chr7:32571352 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.5 6.38 0.36 7.89e-10 Cognitive ability; CESC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg07167872 chr1:205819463 PM20D1 0.37 5.39 0.31 1.56e-7 Menarche (age at onset); CESC cis rs7692995 1.000 rs2085683 chr4:18007435 C/G cg08925142 chr4:18023851 LCORL -0.44 -5.08 -0.3 7.07e-7 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22168255 chr1:156627392 BCAN 0.52 6.13 0.35 3.12e-9 Gut microbiome composition (summer); CESC cis rs826838 0.834 rs826874 chr12:39122599 C/A cg26384229 chr12:38710491 ALG10B -0.63 -10.32 -0.54 3.31e-21 Heart rate; CESC cis rs6456156 0.603 rs2345754 chr6:167484361 T/C cg23791538 chr6:167370224 RNASET2 -0.51 -6.44 -0.37 5.67e-10 Primary biliary cholangitis; CESC cis rs11098499 0.866 rs12510451 chr4:120289143 C/T cg09307838 chr4:120376055 NA 0.87 12.16 0.6 2.41e-27 Corneal astigmatism; CESC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg19626725 chr5:178986131 RUFY1 0.41 6.69 0.38 1.34e-10 Lung cancer; CESC cis rs4728302 0.869 rs13233690 chr7:133587328 C/T cg10665199 chr7:133106180 EXOC4 0.39 5.43 0.32 1.29e-7 Intelligence;Intelligence (multi-trait analysis); CESC cis rs11264213 0.786 rs72659671 chr1:36237762 C/T cg27506609 chr1:36549197 TEKT2 0.65 5.34 0.31 1.97e-7 Schizophrenia; CESC cis rs13256369 0.853 rs13256216 chr8:8577883 C/T cg18904891 chr8:8559673 CLDN23 0.65 7.1 0.4 1.16e-11 Obesity-related traits; CESC cis rs9325144 0.555 rs7977200 chr12:38713745 C/T cg26384229 chr12:38710491 ALG10B 0.59 8.37 0.46 3.43e-15 Morning vs. evening chronotype; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26007659 chr1:146643600 PRKAB2 -0.49 -6.13 -0.35 3.1e-9 Asthma; CESC cis rs9911578 0.692 rs411988 chr17:56709034 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.41 5.44 0.32 1.21e-7 Intelligence (multi-trait analysis); CESC cis rs4319547 0.695 rs10773152 chr12:122910180 T/C cg05707623 chr12:122985044 ZCCHC8 -0.54 -6.19 -0.36 2.3e-9 Body mass index; CESC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg03013636 chr16:1946785 NA 0.48 6.62 0.38 2.02e-10 Glomerular filtration rate in chronic kidney disease; CESC cis rs9911578 0.935 rs2567912 chr17:56731270 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.29 0.31 2.5e-7 Intelligence (multi-trait analysis); CESC cis rs6500395 1.000 rs3848321 chr16:48620780 A/T cg04672837 chr16:48644449 N4BP1 0.51 6.5 0.37 3.95e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg22823121 chr1:150693482 HORMAD1 0.44 6.11 0.35 3.48e-9 Melanoma; CESC cis rs1008375 1.000 rs2058339 chr4:17678456 C/T cg02297831 chr4:17616191 MED28 0.45 5.82 0.34 1.69e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7647973 0.593 rs4855885 chr3:49690199 G/A cg07636037 chr3:49044803 WDR6 0.52 5.93 0.34 9.51e-9 Menarche (age at onset); CESC cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg23711669 chr6:146136114 FBXO30 0.98 15.12 0.68 1.11e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs2599510 0.807 rs176416 chr2:32652223 A/G cg02381751 chr2:32503542 YIPF4 -0.45 -5.58 -0.32 5.92e-8 Interleukin-18 levels; CESC cis rs9910055 0.552 rs12937114 chr17:42325073 A/G cg13607699 chr17:42295918 UBTF 0.87 12.61 0.61 7.04e-29 Total body bone mineral density; CESC cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.66 0.61 4.8e-29 Colonoscopy-negative controls vs population controls; CESC cis rs9863 0.861 rs4765219 chr12:124440110 G/T cg17562584 chr12:124393655 DNAH10 0.29 5.06 0.3 7.91e-7 White blood cell count; CESC cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg06212747 chr3:49208901 KLHDC8B 0.72 9.73 0.51 2.47e-19 Parkinson's disease; CESC cis rs10771431 1.000 rs10771431 chr12:9380859 C/T cg00504896 chr12:9437009 LOC642846 -0.38 -5.05 -0.3 8.41e-7 Breast size; CESC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg21248554 chr2:27665150 KRTCAP3 -0.28 -5.99 -0.35 6.88e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs79349575 0.783 rs58591767 chr17:47026076 G/A cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs3015497 0.603 rs2291672 chr14:51060452 A/G cg26011998 chr14:51135199 SAV1 -0.48 -5.45 -0.32 1.16e-7 Mean platelet volume; CESC cis rs7789940 0.810 rs12533978 chr7:75943352 T/C cg10167463 chr7:75959203 YWHAG -0.51 -5.89 -0.34 1.17e-8 Multiple sclerosis; CESC trans rs11088226 0.681 rs8131384 chr21:33944127 C/T cg09050820 chr6:167586206 TCP10L2 0.87 8.43 0.46 2.32e-15 Gastritis; CESC cis rs977987 0.778 rs34222958 chr16:75398252 C/T cg03315344 chr16:75512273 CHST6 0.39 5.63 0.33 4.61e-8 Dupuytren's disease; CESC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg12463550 chr7:65579703 CRCP -0.56 -7.09 -0.4 1.25e-11 Aortic root size; CESC cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg26597838 chr10:835615 NA 0.76 7.14 0.4 8.95e-12 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06458679 chr21:46974866 NA 0.58 6.95 0.39 2.75e-11 Gut microbiome composition (summer); CESC cis rs7714584 1.000 rs10463307 chr5:150254620 C/T cg22134413 chr5:150180641 NA 0.51 5.5 0.32 8.92e-8 Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16793757 chr10:62098976 ANK3 -0.44 -6.35 -0.36 9.46e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4975616 0.869 rs452932 chr5:1330253 T/C cg06550200 chr5:1325588 CLPTM1L -0.7 -11.16 -0.57 5.97e-24 Lung cancer; CESC cis rs1577917 0.771 rs2758847 chr6:86349103 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.53 -7.03 -0.4 1.71e-11 Response to antipsychotic treatment; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01759413 chr5:180650114 TRIM41 0.54 6.01 0.35 6.01e-9 Gut microbiome composition (summer); CESC cis rs875971 0.867 rs13227219 chr7:65844062 T/A cg10691866 chr7:65817282 TPST1 -0.32 -5.06 -0.3 7.94e-7 Aortic root size; CESC cis rs2280018 0.963 rs12928424 chr16:15150773 C/G cg27102117 chr16:15229624 NA 0.48 7.5 0.42 9.75e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs10504229 0.575 rs78075335 chr8:57997243 A/C cg22535103 chr8:58192502 C8orf71 -0.56 -6.58 -0.37 2.48e-10 Developmental language disorder (linguistic errors); CESC cis rs2625529 0.668 rs34189331 chr15:72404573 A/T cg16672083 chr15:72433130 SENP8 -0.36 -5.08 -0.3 7.27e-7 Red blood cell count; CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg27094323 chr7:1216898 NA -0.39 -5.28 -0.31 2.64e-7 Longevity;Endometriosis; CESC cis rs1348850 0.914 rs2364854 chr2:178378452 T/A cg22681709 chr2:178499509 PDE11A -0.39 -5.72 -0.33 2.8e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg25072359 chr17:41440525 NA 0.45 6.14 0.35 2.95e-9 Menopause (age at onset); CESC cis rs11828289 0.714 rs1384478 chr11:23243582 T/C cg20040320 chr11:23191996 NA 0.66 5.75 0.33 2.42e-8 Cancer; CESC cis rs2228479 0.557 rs2293584 chr16:89888686 C/G cg00800038 chr16:89945340 TCF25 -0.89 -6.88 -0.39 4.34e-11 Skin colour saturation; CESC cis rs2898681 0.618 rs116241740 chr4:53733523 A/G cg00791764 chr4:53727839 RASL11B 0.51 5.13 0.3 5.53e-7 Optic nerve measurement (cup area); CESC cis rs6120849 0.754 rs6120804 chr20:33623701 C/A cg06115741 chr20:33292138 TP53INP2 0.53 5.05 0.3 8.15e-7 Protein C levels; CESC cis rs17401966 0.931 rs12137880 chr1:10388620 T/C cg15208524 chr1:10270712 KIF1B 0.43 5.47 0.32 1.04e-7 Hepatocellular carcinoma; CESC cis rs4700695 0.668 rs253212 chr5:65497553 C/T cg21114390 chr5:65439923 SFRS12 -0.48 -5.85 -0.34 1.48e-8 Facial morphology (factor 19); CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg21942430 chr1:65613385 AK3L1 0.48 6.29 0.36 1.27e-9 Retinol levels; CESC cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg20701182 chr2:24300061 SF3B14 0.93 10.43 0.54 1.41e-21 Lymphocyte counts; CESC cis rs9611565 0.649 rs126092 chr22:42178441 A/G cg03806693 chr22:41940476 POLR3H 0.71 8.08 0.44 2.25e-14 Vitiligo; CESC cis rs12142240 0.698 rs17413694 chr1:46818416 A/C cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.15e-14 Menopause (age at onset); CESC cis rs8028182 0.636 rs4451914 chr15:75739824 C/T cg20655648 chr15:75932815 IMP3 0.48 6.1 0.35 3.67e-9 Sudden cardiac arrest; CESC cis rs9911578 0.934 rs8081967 chr17:57072701 T/C cg05425664 chr17:57184151 TRIM37 -0.52 -7.09 -0.4 1.21e-11 Intelligence (multi-trait analysis); CESC cis rs11630290 1.000 rs72750986 chr15:63996338 C/A cg12036633 chr15:63758958 NA -0.57 -5.34 -0.31 2.04e-7 Iris characteristics; CESC cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg23711669 chr6:146136114 FBXO30 0.97 14.97 0.68 4.06e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg15052019 chr19:19431593 KIAA0892;SF4 0.43 5.48 0.32 9.84e-8 Tonsillectomy; CESC cis rs4595586 0.546 rs11169801 chr12:39241429 G/A cg13010199 chr12:38710504 ALG10B 0.57 7.65 0.43 3.78e-13 Morning vs. evening chronotype; CESC cis rs17376456 0.825 rs13156202 chr5:93157721 C/T cg21475434 chr5:93447410 FAM172A -0.78 -7.02 -0.4 1.84e-11 Diabetic retinopathy; CESC cis rs6831352 0.918 rs7694646 chr4:100059732 T/A cg12011299 chr4:100065546 ADH4 -0.59 -6.59 -0.38 2.35e-10 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02661258 chr5:14664470 FAM105B 0.57 6.74 0.38 1.01e-10 Gut microbiome composition (summer); CESC cis rs962856 0.619 rs1027000 chr2:67600789 T/C cg09028215 chr2:67624308 ETAA1 -0.42 -5.1 -0.3 6.49e-7 Pancreatic cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20756454 chr17:28951397 LRRC37B2 0.53 6.87 0.39 4.66e-11 Fibrinogen levels; CESC cis rs12477438 0.501 rs11683107 chr2:99759235 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.4 0.64 1.33e-31 Chronic sinus infection; CESC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.06 10.39 0.54 1.98e-21 Platelet count; CESC cis rs3815700 1.000 rs8109990 chr19:33095636 A/G cg02997394 chr19:33096574 ANKRD27 0.71 7.09 0.4 1.21e-11 Eosinophilic esophagitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06733439 chr2:118845890 INSIG2 0.58 6.34 0.36 9.83e-10 Gut microbiome composition (summer); CESC cis rs2204008 0.538 rs11514000 chr12:38067706 A/G cg26384229 chr12:38710491 ALG10B 0.52 7.59 0.42 5.36e-13 Bladder cancer; CESC cis rs67311347 1.000 rs56992941 chr3:40472434 A/T cg09455208 chr3:40491958 NA 0.46 8.07 0.44 2.39e-14 Renal cell carcinoma; CESC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.21 -0.3 3.8e-7 Life satisfaction; CESC trans rs9325144 0.647 rs1875609 chr12:39018259 C/T cg23762105 chr12:34175262 ALG10 0.48 6.33 0.36 1.01e-9 Morning vs. evening chronotype; CESC cis rs6982240 0.569 rs6992286 chr8:142279412 G/A cg00131261 chr8:142287264 NA -0.52 -7.47 -0.42 1.19e-12 Tonsillectomy; CESC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg19592336 chr6:28129416 ZNF389 0.52 6.67 0.38 1.48e-10 Parkinson's disease; CESC cis rs6460942 1.000 rs2053382 chr7:12400587 A/G cg02935154 chr7:12443704 VWDE -0.57 -6.16 -0.35 2.7e-9 Coronary artery disease; CESC trans rs11098499 0.708 rs1546506 chr4:120241240 T/C cg25214090 chr10:38739885 LOC399744 0.62 8.55 0.46 1.01e-15 Corneal astigmatism; CESC cis rs826838 0.935 rs11169508 chr12:39173385 C/T cg26384229 chr12:38710491 ALG10B 0.78 13.0 0.62 3.24e-30 Heart rate; CESC cis rs7666738 0.515 rs13131874 chr4:98779183 A/G cg17366294 chr4:99064904 C4orf37 0.5 6.19 0.36 2.34e-9 Colonoscopy-negative controls vs population controls; CESC cis rs10885582 0.774 rs11196782 chr10:116302495 A/G cg17056676 chr10:116301354 ABLIM1 -0.29 -5.19 -0.3 4.28e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.64 8.1 0.45 2.06e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs3780486 0.846 rs6476402 chr9:33148552 G/A cg13443165 chr9:33130375 B4GALT1 0.47 6.91 0.39 3.6e-11 IgG glycosylation; CESC cis rs7103648 0.669 rs7131262 chr11:47836302 T/A cg20307385 chr11:47447363 PSMC3 0.79 11.51 0.58 3.8e-25 Diastolic blood pressure;Systolic blood pressure; CESC cis rs4948102 0.597 rs12669623 chr7:56139179 G/C cg09872392 chr7:56161020 PHKG1 -0.45 -7.37 -0.41 2.19e-12 Plasma homocysteine levels (post-methionine load test); CESC cis rs3126085 0.877 rs12065368 chr1:152253497 C/T cg03465714 chr1:152285911 FLG -0.45 -5.56 -0.32 6.52e-8 Atopic dermatitis; CESC cis rs116095464 0.558 rs60251075 chr5:245292 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.27 0.31 2.9e-7 Breast cancer; CESC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC cis rs7772486 0.686 rs4896833 chr6:145965673 T/G cg05347473 chr6:146136440 FBXO30 0.53 6.9 0.39 3.92e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4237845 0.591 rs10747788 chr12:58315338 C/T cg02175503 chr12:58329896 NA 0.8 10.59 0.55 4.42e-22 Intelligence (multi-trait analysis); CESC cis rs11955398 0.625 rs11739209 chr5:59959767 T/C cg02684056 chr5:59996105 DEPDC1B 0.4 5.09 0.3 6.86e-7 Intelligence (multi-trait analysis); CESC cis rs631288 0.655 rs4245679 chr1:146710504 C/A cg25205988 chr1:146714368 CHD1L 1.07 6.04 0.35 5.32e-9 PR interval in Tripanosoma cruzi seropositivity; CESC cis rs801193 0.591 rs9986881 chr7:66173040 A/G cg18876405 chr7:65276391 NA 0.4 5.19 0.3 4.29e-7 Aortic root size; CESC cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.49 -5.5 -0.32 8.82e-8 Multiple sclerosis; CESC cis rs11997175 0.568 rs4733169 chr8:33581855 T/C ch.8.33884649F chr8:33765107 NA 0.47 5.65 0.33 4.11e-8 Body mass index; CESC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg06456125 chr7:65229604 NA 0.45 5.91 0.34 1.03e-8 Aortic root size; CESC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.42 -0.32 1.31e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs372883 0.532 rs388707 chr21:30714776 T/C cg24692254 chr21:30365293 RNF160 -0.49 -6.46 -0.37 5.04e-10 Pancreatic cancer; CESC cis rs807669 0.544 rs2040771 chr22:19161935 C/T cg02655711 chr22:19163373 SLC25A1 0.42 6.22 0.36 1.9e-9 Metabolite levels; CESC cis rs4810685 0.816 rs1413146 chr20:46407290 C/T cg08288986 chr20:46415360 SULF2 0.56 6.99 0.39 2.21e-11 Attention deficit hyperactivity disorder (time to onset); CESC cis rs7592578 0.581 rs59109438 chr2:191287683 A/G cg27211696 chr2:191398769 TMEM194B -0.6 -6.15 -0.35 2.88e-9 Diastolic blood pressure; CESC cis rs7843479 0.965 rs1564305 chr8:21803816 A/C cg17168535 chr8:21777572 XPO7 0.5 6.86 0.39 4.85e-11 Mean corpuscular volume; CESC cis rs73206853 0.764 rs55929416 chr12:110622543 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.62 0.33 4.79e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs826838 0.510 rs10506129 chr12:39224242 A/T cg13010199 chr12:38710504 ALG10B 0.58 7.73 0.43 2.17e-13 Heart rate; CESC cis rs12479064 0.724 rs10496336 chr2:99996165 A/G cg09787394 chr2:99771194 LIPT1;TSGA10 0.48 5.03 0.3 8.99e-7 Chronic sinus infection; CESC cis rs6088580 0.634 rs62212172 chr20:32987705 G/A cg08999081 chr20:33150536 PIGU -0.64 -11.24 -0.57 3.23e-24 Glomerular filtration rate (creatinine); CESC cis rs3733585 0.605 rs4697710 chr4:10122649 T/C cg11266682 chr4:10021025 SLC2A9 -0.57 -10.15 -0.53 1.13e-20 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg10691866 chr7:65817282 TPST1 0.33 5.51 0.32 8.51e-8 Aortic root size; CESC cis rs4595586 0.546 rs11609849 chr12:39258090 C/G cg13010199 chr12:38710504 ALG10B 0.58 7.79 0.43 1.52e-13 Morning vs. evening chronotype; CESC cis rs3008870 1.000 rs2815352 chr1:67482104 A/G cg02640540 chr1:67518911 SLC35D1 0.48 5.15 0.3 5.14e-7 Lymphocyte percentage of white cells; CESC cis rs782590 0.559 rs12617719 chr2:55915826 G/C cg18811423 chr2:55921094 PNPT1 -0.71 -10.77 -0.55 1.16e-22 Metabolic syndrome; CESC trans rs8014252 0.667 rs9323536 chr14:70808603 T/C cg03123320 chr1:229394665 NA -0.49 -6.27 -0.36 1.45e-9 Plasma estrone levels in resected estrogen-receptor positive breast cancer; CESC cis rs6121246 0.697 rs7269866 chr20:30232504 G/A cg13852791 chr20:30311386 BCL2L1 0.77 7.91 0.44 7.11e-14 Mean corpuscular hemoglobin; CESC cis rs561341 0.654 rs6505265 chr17:30172580 C/T cg19193384 chr17:30244184 NA 0.54 5.3 0.31 2.43e-7 Hip circumference adjusted for BMI; CESC cis rs3916 1.000 rs1799958 chr12:121176083 G/A cg21892295 chr12:121157589 UNC119B -0.36 -5.24 -0.31 3.24e-7 Urinary metabolites (H-NMR features); CESC cis rs71277158 0.688 rs7618919 chr3:169860239 C/T cg04067573 chr3:169899625 PHC3 0.67 6.87 0.39 4.66e-11 Prostate cancer; CESC cis rs3105593 1.000 rs3131582 chr15:50879670 C/T cg08437265 chr15:50716283 USP8 0.41 5.26 0.31 2.94e-7 QT interval; CESC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg19077165 chr18:44547161 KATNAL2 -0.63 -9.53 -0.51 1.06e-18 Personality dimensions; CESC cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg00934597 chr7:893267 UNC84A -0.5 -6.72 -0.38 1.08e-10 Perceived unattractiveness to mosquitoes; CESC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg24503407 chr1:205819492 PM20D1 0.82 13.96 0.65 1.43e-33 Menarche (age at onset); CESC cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg14416269 chr4:6271139 WFS1 -0.46 -8.0 -0.44 4.02e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg23758822 chr17:41437982 NA 1.03 14.72 0.67 3.07e-36 Menopause (age at onset); CESC cis rs2832077 0.689 rs2832052 chr21:30130073 G/C cg24692254 chr21:30365293 RNF160 -0.42 -5.15 -0.3 5.01e-7 Cognitive test performance; CESC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg14703610 chr5:56206110 C5orf35 0.49 6.56 0.37 2.8e-10 Coronary artery disease; CESC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.84 0.34 1.53e-8 Electroencephalogram traits; CESC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg08470875 chr2:26401718 FAM59B 0.75 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC cis rs9457247 1.000 rs2757042 chr6:167371234 A/T cg07741184 chr6:167504864 NA -0.3 -5.45 -0.32 1.18e-7 Crohn's disease; CESC cis rs644799 1.000 rs473155 chr11:95596873 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.66 8.22 0.45 9.21e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7917772 0.536 rs11191361 chr10:104411958 C/T ch.10.2196322F chr10:104248062 ACTR1A 0.5 5.55 0.32 6.81e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs17102884 0.506 rs4899540 chr14:75403408 G/A cg08847533 chr14:75593920 NEK9 -0.44 -5.49 -0.32 9.41e-8 Neuroticism; CESC cis rs12478296 1.000 rs55777943 chr2:243040686 T/C cg06360820 chr2:242988706 NA -0.92 -8.99 -0.48 4.94e-17 Obesity-related traits; CESC cis rs4595586 0.545 rs969469 chr12:39366775 A/C cg26384229 chr12:38710491 ALG10B 0.5 7.16 0.4 7.88e-12 Morning vs. evening chronotype; CESC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC trans rs11098499 0.754 rs12509621 chr4:120249660 T/C cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs854765 0.583 rs11650649 chr17:17790319 C/A cg04398451 chr17:18023971 MYO15A 0.64 8.87 0.48 1.14e-16 Total body bone mineral density; CESC cis rs6460942 0.915 rs62448602 chr7:12457145 T/G cg06484146 chr7:12443880 VWDE -0.78 -9.14 -0.49 1.68e-17 Coronary artery disease; CESC trans rs61931739 0.500 rs11053272 chr12:34547020 C/G cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg26155979 chr10:105110866 PCGF6 0.49 6.38 0.36 8.07e-10 Breast cancer;Type 2 diabetes; CESC cis rs2599510 0.811 rs62136345 chr2:32807223 G/T cg02381751 chr2:32503542 YIPF4 0.43 5.33 0.31 2.13e-7 Interleukin-18 levels; CESC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg12756686 chr19:29218302 NA 0.59 7.62 0.42 4.52e-13 Methadone dose in opioid dependence; CESC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg24675658 chr1:53192096 ZYG11B -0.69 -8.79 -0.48 1.89e-16 Monocyte count; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg21699506 chr4:80786707 NA 0.41 6.04 0.35 5.3e-9 Ulcerative colitis; CESC cis rs919433 0.783 rs2565155 chr2:198236425 A/G cg10820045 chr2:198174542 NA 0.41 5.93 0.34 9.6e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs651907 0.535 rs9830943 chr3:101428899 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 5.52 0.32 8.16e-8 Colorectal cancer; CESC cis rs1371867 0.875 rs1788178 chr8:101332518 A/C cg11906718 chr8:101322791 RNF19A 0.53 6.86 0.39 4.86e-11 Atrioventricular conduction; CESC cis rs10870270 0.956 rs7915388 chr10:133734972 G/A cg08754478 chr10:133766260 PPP2R2D -0.62 -8.06 -0.44 2.63e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs10781543 0.775 rs10870194 chr9:139327034 A/G cg14019695 chr9:139328340 INPP5E 0.36 5.3 0.31 2.47e-7 Monocyte percentage of white cells; CESC cis rs7208859 0.524 rs73988172 chr17:29086332 A/C cg19761014 chr17:28927070 LRRC37B2 0.78 6.38 0.36 8.01e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg03433033 chr1:76189801 ACADM 0.69 8.44 0.46 2.14e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs9911578 0.967 rs9907940 chr17:56663842 A/G cg05425664 chr17:57184151 TRIM37 -0.48 -6.66 -0.38 1.61e-10 Intelligence (multi-trait analysis); CESC cis rs9291683 0.588 rs35099040 chr4:10018839 T/C cg11266682 chr4:10021025 SLC2A9 0.71 14.52 0.67 1.5e-35 Bone mineral density; CESC cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.76 11.12 0.56 7.93e-24 Monocyte percentage of white cells; CESC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.95 0.44 5.42e-14 Electroencephalogram traits; CESC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.93 9.63 0.51 5.2e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7208859 0.623 rs28556733 chr17:29083945 T/G cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg09997546 chr11:8931473 C11orf17;ST5 -0.31 -5.12 -0.3 6e-7 Hemoglobin concentration; CESC cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg03433033 chr1:76189801 ACADM -0.58 -6.33 -0.36 1.04e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2841277 0.676 rs10438247 chr14:105411781 G/A cg19901468 chr14:105411992 AHNAK2 -0.62 -9.07 -0.49 2.79e-17 Rheumatoid arthritis; CESC cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg12923728 chr3:195709715 SDHAP1 -0.67 -8.8 -0.48 1.78e-16 Pancreatic cancer; CESC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg00106254 chr7:1943704 MAD1L1 -0.5 -6.25 -0.36 1.67e-9 Bipolar disorder and schizophrenia; CESC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg22800045 chr5:56110881 MAP3K1 0.68 8.22 0.45 9.26e-15 Type 2 diabetes; CESC cis rs727505 0.721 rs11534064 chr7:124767997 G/T cg23710748 chr7:124431027 NA 0.32 5.43 0.32 1.26e-7 Lewy body disease; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg14574726 chr11:809735 RPLP2 -0.39 -6.28 -0.36 1.41e-9 Vertical cup-disc ratio; CESC cis rs854765 0.647 rs712267 chr17:18021607 G/A cg04398451 chr17:18023971 MYO15A -0.8 -11.75 -0.59 6.09e-26 Total body bone mineral density; CESC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg12963246 chr6:28129442 ZNF389 0.46 6.18 0.36 2.38e-9 Parkinson's disease; CESC cis rs9287719 0.967 rs7587114 chr2:10739963 C/T cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs16866061 0.962 rs3845840 chr2:225359100 G/A cg12698349 chr2:225449008 CUL3 0.72 10.55 0.54 5.98e-22 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs193541 0.632 rs2910135 chr5:122229790 C/T cg19412675 chr5:122181750 SNX24 0.48 5.69 0.33 3.39e-8 Glucose homeostasis traits; CESC cis rs76878669 0.561 rs10791872 chr11:66138434 C/G cg18002602 chr11:66138449 SLC29A2 -0.41 -6.84 -0.39 5.38e-11 Educational attainment (years of education); CESC cis rs1691799 0.899 rs1168327 chr12:66728842 G/A cg16791601 chr12:66731901 HELB -0.73 -12.46 -0.61 2.25e-28 White blood cell count (basophil); CESC cis rs2228479 0.850 rs3785279 chr16:89824562 G/C cg06558623 chr16:89946397 TCF25 1.17 9.38 0.5 3.19e-18 Skin colour saturation; CESC cis rs7927771 0.524 rs754434 chr11:47814280 A/G cg18512352 chr11:47633146 NA 0.35 5.33 0.31 2.05e-7 Subjective well-being; CESC cis rs2066819 1.000 rs2695789 chr12:56694261 C/A cg26714650 chr12:56694279 CS 1.29 16.3 0.71 7.7e-42 Psoriasis vulgaris; CESC trans rs7726839 0.561 rs6555357 chr5:560923 A/G cg25482853 chr8:67687455 SGK3 0.93 10.03 0.52 2.74e-20 Obesity-related traits; CESC cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg11752832 chr7:134001865 SLC35B4 0.52 6.58 0.37 2.49e-10 Mean platelet volume; CESC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg01570182 chr17:44337453 NA -0.6 -8.25 -0.45 7.42e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.49 6.97 0.39 2.44e-11 Bipolar disorder; CESC cis rs854765 0.547 rs4459604 chr17:17888549 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.53 6.68 0.38 1.4e-10 Total body bone mineral density; CESC cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg04455712 chr21:45112962 RRP1B 0.37 5.52 0.32 7.97e-8 Mean corpuscular volume; CESC cis rs9811920 0.660 rs7619512 chr3:99729132 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.4 -6.51 -0.37 3.79e-10 Axial length; CESC trans rs3942852 0.806 rs10769316 chr11:48119745 C/G cg15704280 chr7:45808275 SEPT13 -0.63 -7.45 -0.42 1.3e-12 Acute lymphoblastic leukemia (childhood); CESC cis rs7772486 0.790 rs2253764 chr6:146199881 T/A cg05347473 chr6:146136440 FBXO30 0.55 7.24 0.41 4.76e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs6964587 0.869 rs405 chr7:91546327 G/C cg17063962 chr7:91808500 NA -0.52 -6.86 -0.39 4.85e-11 Breast cancer; CESC cis rs79057730 0.599 rs6951032 chr7:794092 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.91 7.75 0.43 1.92e-13 Initial pursuit acceleration; CESC cis rs2637266 0.935 rs1907299 chr10:78325316 T/C cg18941641 chr10:78392320 NA 0.38 6.83 0.39 5.66e-11 Pulmonary function; CESC cis rs6546537 0.955 rs35947226 chr2:69845829 C/G cg10773587 chr2:69614142 GFPT1 -0.59 -7.02 -0.4 1.81e-11 Serum thyroid-stimulating hormone levels; CESC cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -7.5 -0.42 9.68e-13 Personality dimensions; CESC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg22307029 chr19:49891270 CCDC155 0.54 5.97 0.34 7.51e-9 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23921860 chr17:4608406 PELP1 -0.6 -6.98 -0.39 2.3e-11 Gut microbiome composition (summer); CESC cis rs4561483 0.583 rs62038798 chr16:12001569 C/T cg08843971 chr16:11963173 GSPT1 0.47 6.56 0.37 2.88e-10 Testicular germ cell tumor; CESC cis rs6695640 0.820 rs1535874 chr1:17748027 C/T cg01904812 chr1:17746340 RCC2 -0.35 -5.17 -0.3 4.65e-7 Mean platelet volume; CESC cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg07636037 chr3:49044803 WDR6 1.06 19.52 0.77 3.45e-53 Parkinson's disease; CESC cis rs6662572 0.737 rs6429593 chr1:46505235 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 5.3 0.31 2.45e-7 Blood protein levels; CESC cis rs672059 1.000 rs547905 chr1:183157924 G/A ch.1.3577855R chr1:183094577 LAMC1 0.57 7.36 0.41 2.35e-12 Hypertriglyceridemia; CESC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg25036284 chr2:26402008 FAM59B 0.84 9.45 0.5 1.91e-18 Gut microbiome composition (summer); CESC cis rs11785400 1.000 rs754957 chr8:143746416 A/G cg24634471 chr8:143751801 JRK 0.47 6.23 0.36 1.87e-9 Schizophrenia; CESC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg07234876 chr8:600039 NA -0.88 -6.43 -0.37 5.87e-10 IgG glycosylation; CESC cis rs34638657 0.827 rs11641736 chr16:82206279 G/A cg09439754 chr16:82129088 HSD17B2 -0.37 -5.22 -0.31 3.56e-7 Lung adenocarcinoma; CESC cis rs4654899 0.802 rs57351360 chr1:21229538 T/A cg05370193 chr1:21551575 ECE1 0.38 5.52 0.32 8.12e-8 Superior frontal gyrus grey matter volume; CESC cis rs9291683 0.632 rs12508991 chr4:10041104 C/T cg11266682 chr4:10021025 SLC2A9 0.67 13.02 0.62 2.72e-30 Bone mineral density; CESC cis rs6088590 1.000 rs6088615 chr20:33400474 C/T cg06115741 chr20:33292138 TP53INP2 -0.54 -6.45 -0.37 5.18e-10 Coronary artery disease; CESC cis rs4319547 0.619 rs10744208 chr12:122931559 C/A cg23029597 chr12:123009494 RSRC2 -0.45 -5.08 -0.3 7.04e-7 Body mass index; CESC cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg12927641 chr6:109611667 NA -0.43 -6.7 -0.38 1.22e-10 Reticulocyte fraction of red cells; CESC cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg02297831 chr4:17616191 MED28 0.58 7.14 0.4 8.79e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg12311346 chr5:56204834 C5orf35 -0.74 -8.81 -0.48 1.71e-16 Initial pursuit acceleration; CESC cis rs2777491 0.874 rs28716108 chr15:41655523 G/C cg01768344 chr15:41576519 LOC729082 0.41 5.03 0.3 8.98e-7 Ulcerative colitis; CESC cis rs6460942 0.908 rs79175014 chr7:12245378 T/G cg20607287 chr7:12443886 VWDE -0.61 -6.14 -0.35 2.93e-9 Coronary artery disease; CESC cis rs3126085 0.935 rs3126072 chr1:152279729 C/T cg03465714 chr1:152285911 FLG 0.43 5.2 0.3 3.94e-7 Atopic dermatitis; CESC cis rs1005277 0.502 rs2800484 chr10:38542415 C/T cg25427524 chr10:38739819 LOC399744 -0.72 -10.76 -0.55 1.2e-22 Extrinsic epigenetic age acceleration; CESC cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg17366294 chr4:99064904 C4orf37 0.59 8.57 0.47 8.46e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7264396 0.622 rs3787165 chr20:34228946 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 7.56 0.42 6.68e-13 Total cholesterol levels; CESC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg05341575 chr12:125625032 AACS 0.35 5.21 0.3 3.79e-7 Post bronchodilator FEV1/FVC ratio; CESC cis rs2635047 0.569 rs9958817 chr18:44786481 G/A cg24371990 chr18:44770781 NA 0.36 5.82 0.34 1.69e-8 Educational attainment; CESC cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 -0.37 -5.89 -0.34 1.15e-8 Hip circumference adjusted for BMI; CESC cis rs41271951 0.512 rs11204774 chr1:151062957 C/T cg11822372 chr1:151115635 SEMA6C -0.62 -5.36 -0.31 1.8e-7 Blood protein levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10859966 chr14:24898992 CBLN3;KHNYN -0.52 -6.44 -0.37 5.7e-10 Ulcerative colitis; CESC cis rs11098499 0.909 rs1809406 chr4:120377122 G/A cg24375607 chr4:120327624 NA 0.44 5.51 0.32 8.65e-8 Corneal astigmatism; CESC cis rs858239 0.600 rs7776644 chr7:23119307 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.73 0.43 2.24e-13 Cerebrospinal fluid biomarker levels; CESC cis rs909674 0.690 rs5750823 chr22:39829973 C/T cg02038168 chr22:39784481 NA -0.61 -7.88 -0.44 8.37e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs7216064 1.000 rs55939964 chr17:65869297 G/A cg12091567 chr17:66097778 LOC651250 -0.85 -8.7 -0.47 3.61e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23029715 chr19:42363959 RPS19 -0.53 -6.12 -0.35 3.27e-9 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.39 5.3 0.31 2.46e-7 Menopause (age at onset); CESC cis rs7116495 0.609 rs949324 chr11:71714526 G/C cg26138937 chr11:71823887 C11orf51 -1.16 -7.82 -0.43 1.29e-13 Severe influenza A (H1N1) infection; CESC cis rs367943 1.000 rs348956 chr5:112821464 C/T cg12552261 chr5:112820674 MCC 0.64 8.05 0.44 2.83e-14 Type 2 diabetes; CESC cis rs6754311 0.689 rs192822 chr2:136682274 A/T cg07169764 chr2:136633963 MCM6 0.71 9.07 0.49 2.8e-17 Mosquito bite size; CESC cis rs4971059 0.629 rs12904 chr1:155106697 G/A cg22049894 chr1:155113146 DPM3 0.46 5.95 0.34 8.68e-9 Breast cancer; CESC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg11764359 chr7:65958608 NA -0.79 -11.97 -0.59 1.07e-26 Aortic root size; CESC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg08736216 chr1:53307985 ZYG11A 0.36 6.47 0.37 4.6e-10 Monocyte count; CESC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg07936489 chr17:37558343 FBXL20 0.78 11.03 0.56 1.58e-23 Glomerular filtration rate (creatinine); CESC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg16145915 chr7:1198662 ZFAND2A 0.49 7.32 0.41 2.93e-12 Longevity;Endometriosis; CESC cis rs6500395 0.775 rs1968902 chr16:48663974 A/G cg04672837 chr16:48644449 N4BP1 0.49 6.27 0.36 1.5e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7208859 0.614 rs9914534 chr17:29202664 G/A cg19761014 chr17:28927070 LRRC37B2 0.63 5.27 0.31 2.88e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13679837 chr20:21283918 XRN2 0.65 7.28 0.41 3.83e-12 Gut microbiome composition (summer); CESC cis rs933688 0.938 rs7720235 chr5:90659329 A/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.16 15.37 0.69 1.51e-38 Smoking behavior; CESC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.79 0.43 1.49e-13 Electroencephalogram traits; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg25447359 chr22:30790057 NA -0.47 -6.55 -0.37 3.04e-10 Breast cancer;Type 2 diabetes; CESC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg24250549 chr1:154909240 PMVK 0.74 11.09 0.56 1.01e-23 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13107428 chr1:197744541 DENND1B 0.59 6.71 0.38 1.19e-10 Gut microbiome composition (summer); CESC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg00933542 chr6:150070202 PCMT1 0.3 5.23 0.31 3.39e-7 Lung cancer; CESC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg16325326 chr1:53192061 ZYG11B -0.88 -15.0 -0.68 3.14e-37 Monocyte count; CESC cis rs10461617 0.535 rs7709874 chr5:56047451 C/T cg22800045 chr5:56110881 MAP3K1 0.6 7.53 0.42 8.21e-13 Type 2 diabetes; CESC cis rs8017423 0.967 rs57793584 chr14:90714833 G/A cg14092571 chr14:90743983 NA -0.58 -8.66 -0.47 4.57e-16 Mortality in heart failure; CESC cis rs826838 0.900 rs1403523 chr12:39130570 T/A cg26384229 chr12:38710491 ALG10B -0.67 -11.03 -0.56 1.63e-23 Heart rate; CESC cis rs1620921 0.524 rs12194271 chr6:161195895 A/G cg01280913 chr6:161186852 NA -0.4 -6.12 -0.35 3.42e-9 Lipoprotein (a) - cholesterol levels; CESC cis rs708547 0.830 rs1713983 chr4:57883084 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.66 8.59 0.47 7.72e-16 Response to bleomycin (chromatid breaks); CESC cis rs740474 0.554 rs251041 chr5:141027888 C/G cg00076195 chr5:140892677 NA 0.39 5.07 0.3 7.35e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs7927771 0.542 rs7108479 chr11:47781460 G/T cg18512352 chr11:47633146 NA 0.34 5.24 0.31 3.22e-7 Subjective well-being; CESC cis rs10788264 0.621 rs9633733 chr10:124056546 A/G cg09507567 chr10:124027408 NA -0.38 -5.7 -0.33 3.15e-8 Total body bone mineral density; CESC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg02951883 chr7:2050386 MAD1L1 -0.58 -7.77 -0.43 1.72e-13 Bipolar disorder and schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05920998 chr6:656504 HUS1B;EXOC2 -0.56 -6.2 -0.36 2.11e-9 Gut microbiome composition (summer); CESC cis rs8067354 0.645 rs2132715 chr17:57858374 A/T cg13753209 chr17:57696993 CLTC 0.57 6.44 0.37 5.46e-10 Hemoglobin concentration; CESC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg06808227 chr14:105710500 BRF1 -0.58 -7.07 -0.4 1.35e-11 Mean platelet volume;Platelet distribution width; CESC cis rs1707322 1.000 rs10890365 chr1:46359348 C/T cg03146154 chr1:46216737 IPP 0.72 9.96 0.52 4.71e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg19592336 chr6:28129416 ZNF389 0.61 8.03 0.44 3.13e-14 Depression; CESC cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg23462726 chr11:62437636 C11orf83;C11orf48 -0.39 -5.11 -0.3 6.2e-7 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs8014204 0.836 rs7153700 chr14:75268544 C/T cg08847533 chr14:75593920 NEK9 0.46 5.8 0.34 1.93e-8 Caffeine consumption; CESC cis rs3087591 1.000 rs2854332 chr17:29712378 A/T cg24425628 chr17:29625626 OMG;NF1 -0.42 -5.11 -0.3 6.08e-7 Hip circumference; CESC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.53 -5.91 -0.34 1.06e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg12292205 chr6:26970375 C6orf41 -0.53 -5.76 -0.33 2.33e-8 Intelligence (multi-trait analysis); CESC cis rs2228479 0.850 rs11644526 chr16:89898660 C/T cg14709524 chr16:89940631 TCF25 0.88 6.1 0.35 3.82e-9 Skin colour saturation; CESC cis rs62064224 0.589 rs4523973 chr17:30809455 G/A cg18200150 chr17:30822561 MYO1D 0.42 5.38 0.31 1.64e-7 Schizophrenia; CESC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg12463550 chr7:65579703 CRCP 0.51 6.37 0.36 8.13e-10 Aortic root size; CESC cis rs1975974 0.935 rs41361749 chr17:21732693 A/G cg18423549 chr17:21743878 NA 0.45 6.02 0.35 5.89e-9 Psoriasis; CESC cis rs2742234 0.541 rs1254959 chr10:43700979 C/G cg07801480 chr10:43725741 RASGEF1A -0.41 -5.33 -0.31 2.14e-7 Hirschsprung disease; CESC cis rs34779708 0.898 rs4934695 chr10:35280605 C/T cg04310649 chr10:35416472 CREM -0.5 -6.06 -0.35 4.78e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg18252515 chr7:66147081 NA 0.42 5.59 0.32 5.6e-8 Aortic root size; CESC cis rs7818345 1.000 rs7823194 chr8:19292528 C/T cg11303988 chr8:19266685 CSGALNACT1 0.35 6.32 0.36 1.08e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg05368731 chr17:41323189 NBR1 0.79 10.98 0.56 2.21e-23 Menopause (age at onset); CESC cis rs6688613 0.685 rs61815130 chr1:166910465 T/C ch.1.3259774R chr1:166827647 TADA1 0.57 5.27 0.31 2.9e-7 Refractive astigmatism; CESC cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg02297831 chr4:17616191 MED28 -0.54 -6.37 -0.36 8.46e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6460942 0.556 rs2287067 chr7:12370533 T/C cg20607287 chr7:12443886 VWDE -0.52 -7.48 -0.42 1.09e-12 Coronary artery disease; CESC cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg01475377 chr6:109611718 NA 0.48 7.63 0.42 4.2e-13 Reticulocyte fraction of red cells; CESC cis rs3733585 0.699 rs6823361 chr4:9963127 A/G cg11266682 chr4:10021025 SLC2A9 -0.6 -11.22 -0.57 3.77e-24 Cleft plate (environmental tobacco smoke interaction); CESC trans rs9929218 0.954 rs12919719 chr16:68822341 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.61 -7.94 -0.44 5.84e-14 Colorectal cancer; CESC cis rs3733585 0.673 rs6840802 chr4:9965633 C/G cg11266682 chr4:10021025 SLC2A9 0.59 10.46 0.54 1.14e-21 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11098499 0.818 rs7688802 chr4:120451668 G/A cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs9611565 0.765 rs132907 chr22:41801268 A/C cg06634786 chr22:41940651 POLR3H 0.73 7.47 0.42 1.2e-12 Vitiligo; CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg03188948 chr7:1209495 NA 0.48 6.18 0.35 2.39e-9 Longevity;Endometriosis; CESC trans rs2235573 0.551 rs139897 chr22:38399098 A/G cg19894588 chr14:64061835 NA 0.58 7.43 0.42 1.51e-12 Glioblastoma;Glioma; CESC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg27297192 chr10:134578999 INPP5A 0.37 5.03 0.3 8.85e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs637571 0.522 rs606978 chr11:65711517 A/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.7 9.76 0.51 2.03e-19 Eosinophil percentage of white cells; CESC cis rs2502731 0.539 rs3003609 chr9:130984755 A/G cg09976142 chr9:130955436 CIZ1 -0.39 -6.36 -0.36 8.71e-10 Attention deficit hyperactivity disorder; CESC cis rs7512552 0.803 rs2454286 chr1:150355538 G/A cg15654264 chr1:150340011 RPRD2 0.4 5.27 0.31 2.89e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs769267 0.792 rs4808961 chr19:19577215 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.46 5.68 0.33 3.6e-8 Tonsillectomy; CESC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg17221315 chr6:27791827 HIST1H4J 0.63 5.28 0.31 2.67e-7 Depression; CESC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 6.23 0.36 1.78e-9 Bipolar disorder; CESC cis rs6500395 0.962 rs9934626 chr16:48602761 G/C cg04672837 chr16:48644449 N4BP1 0.47 5.8 0.34 1.9e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs7124681 0.584 rs7950674 chr11:47871017 T/C cg20307385 chr11:47447363 PSMC3 0.63 8.8 0.48 1.84e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg01510332 chr19:59087201 MGC2752 0.47 5.99 0.35 6.69e-9 Tetralogy of Fallot; CESC cis rs10779751 0.960 rs1883964 chr1:11294942 T/A cg08854313 chr1:11322531 MTOR 0.79 10.78 0.55 1.06e-22 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04977610 chr16:30366665 CD2BP2 0.65 7.83 0.43 1.14e-13 Gut microbiome composition (summer); CESC cis rs9948 0.748 rs62156223 chr2:97412167 T/C cg01990225 chr2:97406019 LMAN2L -0.87 -6.74 -0.38 9.62e-11 Erectile dysfunction and prostate cancer treatment; CESC cis rs4851870 0.560 rs11690510 chr2:106446674 T/C cg16077055 chr2:106428750 NCK2 -0.36 -5.2 -0.3 3.93e-7 Addiction; CESC cis rs3008870 1.000 rs2985794 chr1:67425311 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs7605827 0.930 rs4668909 chr2:15607842 T/C cg19274914 chr2:15703543 NA 0.33 5.96 0.34 8.22e-9 Educational attainment (years of education); CESC cis rs5769765 0.908 rs138880 chr22:50218611 A/C cg02269571 chr22:50332266 NA -0.43 -5.49 -0.32 9.29e-8 Schizophrenia; CESC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg07648498 chr16:89883185 FANCA -0.5 -6.34 -0.36 9.78e-10 Vitiligo; CESC cis rs7772486 0.817 rs2144477 chr6:146406248 C/T cg23711669 chr6:146136114 FBXO30 0.85 12.48 0.61 2.01e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs2197308 0.728 rs7304305 chr12:37932990 T/C cg26384229 chr12:38710491 ALG10B -0.54 -7.66 -0.43 3.57e-13 Morning vs. evening chronotype; CESC cis rs3091242 0.904 rs6661533 chr1:25771715 A/G cg03538708 chr1:25844672 NA -0.41 -6.17 -0.35 2.53e-9 Erythrocyte sedimentation rate; CESC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg26343298 chr8:95960752 TP53INP1 0.36 6.05 0.35 4.98e-9 Type 2 diabetes; CESC cis rs4808199 0.947 rs10401193 chr19:19591066 A/G cg03709012 chr19:19516395 GATAD2A 1.15 13.17 0.63 8.54e-31 Nonalcoholic fatty liver disease; CESC cis rs17431357 0.867 rs117264981 chr12:120997625 A/C cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs6430585 0.528 rs309151 chr2:136661150 C/T cg07169764 chr2:136633963 MCM6 1.1 14.75 0.67 2.41e-36 Corneal structure; CESC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -6.93 -0.39 3.2e-11 Bipolar disorder and schizophrenia; CESC cis rs10779751 1.000 rs2016559 chr1:11269917 G/T cg08854313 chr1:11322531 MTOR 0.78 10.59 0.55 4.41e-22 Body mass index; CESC cis rs765787 0.530 rs11634794 chr15:45534492 A/C cg24006582 chr15:45444508 DUOX1 -0.55 -6.68 -0.38 1.42e-10 Uric acid levels; CESC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg20891558 chr2:74357851 NA 0.87 12.04 0.59 6.34e-27 Gestational age at birth (maternal effect); CESC cis rs7223966 0.921 rs11655493 chr17:61733052 C/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.1 -0.3 6.57e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7208859 0.524 rs59913838 chr17:29101563 A/T cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9902453 0.808 rs12452288 chr17:28235220 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.2 0.45 1.05e-14 Coffee consumption (cups per day); CESC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg24881330 chr22:46731750 TRMU 0.86 7.93 0.44 6.07e-14 LDL cholesterol;Cholesterol, total; CESC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.38 0.41 1.99e-12 Depression; CESC cis rs6964587 1.000 rs2299239 chr7:91654617 C/T cg17063962 chr7:91808500 NA 0.58 8.02 0.44 3.36e-14 Breast cancer; CESC cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg23583168 chr7:148888333 NA 0.73 10.68 0.55 2.23e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg23422044 chr7:1970798 MAD1L1 -0.5 -5.41 -0.32 1.43e-7 Bipolar disorder; CESC cis rs727505 0.866 rs66650870 chr7:124713194 T/C cg23710748 chr7:124431027 NA -0.4 -6.54 -0.37 3.1e-10 Lewy body disease; CESC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg22433210 chr17:43662623 NA 0.97 10.86 0.55 5.52e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1559088 0.600 rs7256470 chr19:33558085 C/A cg03563238 chr19:33554763 RHPN2 -0.32 -5.78 -0.33 2.09e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg05347473 chr6:146136440 FBXO30 0.58 7.37 0.41 2.23e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9905704 0.918 rs2611783 chr17:56808530 A/G cg12560992 chr17:57184187 TRIM37 0.59 7.01 0.4 1.92e-11 Testicular germ cell tumor; CESC cis rs7589728 0.925 rs78829281 chr2:88502293 T/A cg04511125 chr2:88470314 THNSL2 0.57 5.47 0.32 1.06e-7 Plasma clusterin levels; CESC cis rs2304069 0.545 rs4705404 chr5:149381952 A/C cg12661370 chr5:149340060 SLC26A2 0.43 5.64 0.33 4.32e-8 HIV-1 control; CESC cis rs72781680 1.000 rs7578969 chr2:24168620 T/C cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs2070488 0.574 rs57754356 chr3:38488706 C/G cg24069376 chr3:38537580 EXOG 0.32 5.47 0.32 1.03e-7 Electrocardiographic conduction measures; CESC cis rs5758659 0.504 rs133367 chr22:42463366 A/G cg15557168 chr22:42548783 NA 0.41 6.29 0.36 1.32e-9 Cognitive function; CESC trans rs7246760 0.867 rs889177 chr19:9846225 C/T cg02900749 chr2:68251473 NA -0.82 -7.35 -0.41 2.45e-12 Pursuit maintenance gain; CESC cis rs5753618 0.509 rs5997912 chr22:31593861 A/G cg13145458 chr22:31556086 RNF185 0.48 5.45 0.32 1.15e-7 Colorectal cancer; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg18490802 chr7:6049303 PMS2;AIMP2 -0.46 -6.87 -0.39 4.65e-11 Gambling; CESC cis rs9929218 0.551 rs9888942 chr16:68727572 A/G cg01251360 chr16:68772225 CDH1 -0.23 -5.13 -0.3 5.55e-7 Colorectal cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg02958194 chr7:97736036 LMTK2 0.5 6.25 0.36 1.61e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs1814175 0.645 rs1851844 chr11:50021773 T/C cg15704280 chr7:45808275 SEPT13 -1.0 -18.54 -0.75 9.01e-50 Height; CESC cis rs2933343 0.700 rs1680788 chr3:128625318 C/T cg25356066 chr3:128598488 ACAD9 0.58 7.92 0.44 6.51e-14 IgG glycosylation; CESC cis rs8099014 0.725 rs10871755 chr18:56094783 C/G cg12827950 chr18:55968429 NEDD4L -0.45 -5.07 -0.3 7.51e-7 Platelet count; CESC cis rs12142240 0.659 rs111723629 chr1:46853361 G/T cg00530320 chr1:46809349 NSUN4 0.6 8.3 0.45 5.19e-15 Menopause (age at onset); CESC cis rs7827290 0.863 rs7014099 chr8:142305766 C/T cg00131261 chr8:142287264 NA 0.4 5.11 0.3 6.13e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12214665 chr6:138188557 TNFAIP3 0.57 6.36 0.36 8.9e-10 Gut microbiome composition (summer); CESC cis rs6460942 0.591 rs62451461 chr7:12355480 G/A cg20607287 chr7:12443886 VWDE -0.59 -6.27 -0.36 1.43e-9 Coronary artery disease; CESC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg25036284 chr2:26402008 FAM59B -0.88 -9.99 -0.52 3.79e-20 Gut microbiome composition (summer); CESC cis rs910316 0.967 rs175451 chr14:75589729 C/T cg11812906 chr14:75593930 NEK9 -0.85 -14.31 -0.66 8.38e-35 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27328408 chr15:75615005 NA -0.6 -6.88 -0.39 4.34e-11 Gut microbiome composition (summer); CESC cis rs9389248 0.737 rs12664956 chr6:135384188 T/C cg22676075 chr6:135203613 NA 0.54 7.0 0.4 2.06e-11 High light scatter reticulocyte percentage of red cells; CESC cis rs11785400 0.612 rs10110864 chr8:143750072 A/G cg10596483 chr8:143751796 JRK 0.42 5.2 0.3 3.92e-7 Schizophrenia; CESC cis rs62064224 0.702 rs2302277 chr17:30791509 C/G cg24550644 chr17:30846204 MYO1D -0.38 -5.6 -0.33 5.28e-8 Schizophrenia; CESC cis rs317689 0.918 rs581911 chr12:69738293 C/T cg20891283 chr12:69753455 YEATS4 0.6 6.66 0.38 1.56e-10 Response to diuretic therapy; CESC cis rs3806843 1.000 rs1548699 chr5:140164918 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.18 -0.3 4.31e-7 Depressive symptoms (multi-trait analysis); CESC cis rs858239 0.600 rs6967419 chr7:23136310 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.61 0.42 4.84e-13 Cerebrospinal fluid biomarker levels; CESC cis rs1008375 1.000 rs6849704 chr4:17652031 G/C cg16339924 chr4:17578868 LAP3 0.56 7.02 0.4 1.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg02951883 chr7:2050386 MAD1L1 0.39 5.06 0.3 7.99e-7 Bipolar disorder and schizophrenia; CESC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg00149659 chr3:10157352 C3orf10 0.75 9.44 0.5 2.06e-18 Alzheimer's disease; CESC cis rs10791097 0.694 rs4459316 chr11:130756176 T/C cg09137382 chr11:130731461 NA 0.35 5.21 0.3 3.81e-7 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2737618 0.674 rs2816973 chr1:200084743 C/G cg21825944 chr1:200113062 NR5A2 0.47 7.37 0.41 2.21e-12 Uric acid levels; CESC cis rs1707322 1.000 rs4606257 chr1:46307268 G/A cg06784218 chr1:46089804 CCDC17 0.35 5.91 0.34 1.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs826838 0.935 rs11169511 chr12:39175802 T/C cg13010199 chr12:38710504 ALG10B 0.58 8.08 0.44 2.27e-14 Heart rate; CESC cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.09 0.3 6.71e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2228479 0.850 rs17227057 chr16:89816333 C/T cg06558623 chr16:89946397 TCF25 1.16 9.28 0.5 6.08e-18 Skin colour saturation; CESC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg03188948 chr7:1209495 NA 0.73 7.02 0.4 1.85e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg14530801 chr4:4544016 STX18 -0.49 -6.05 -0.35 4.8e-9 Thyroid stimulating hormone; CESC cis rs12464559 0.649 rs2030588 chr2:152668750 C/A cg01189475 chr2:152685088 ARL5A 0.66 5.81 0.34 1.74e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg23018236 chr17:30244563 NA -0.55 -5.31 -0.31 2.37e-7 Hip circumference adjusted for BMI; CESC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs826838 1.000 rs7299124 chr12:39002661 T/C cg13010199 chr12:38710504 ALG10B 0.59 8.22 0.45 8.93e-15 Heart rate; CESC cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.33 5.2 0.3 4.06e-7 Personality dimensions; CESC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg17372223 chr3:52568218 NT5DC2 0.52 8.67 0.47 4.36e-16 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23009962 chr19:18572435 ELL -0.62 -6.89 -0.39 4.02e-11 Gut microbiome composition (summer); CESC cis rs3768617 0.510 rs4651139 chr1:183091963 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01593421 chr7:65303149 NA 0.45 6.33 0.36 1.02e-9 Fibrinogen levels; CESC cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg04455712 chr21:45112962 RRP1B 0.38 5.58 0.32 6.09e-8 Mean corpuscular volume; CESC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs8078723 0.510 rs11655264 chr17:38138995 G/C cg17344932 chr17:38183730 MED24;SNORD124 0.39 5.79 0.34 1.96e-8 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs12477438 0.520 rs13004491 chr2:99738008 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.88 15.61 0.69 2.15e-39 Chronic sinus infection; CESC cis rs12477438 0.520 rs6708576 chr2:99801308 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.9 15.49 0.69 5.56e-39 Chronic sinus infection; CESC cis rs711245 0.573 rs7570763 chr2:36800589 A/C cg09467607 chr2:36825704 FEZ2 -0.58 -10.17 -0.53 1.01e-20 Height; CESC cis rs7208859 0.623 rs77009951 chr17:29080650 T/C cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12586317 0.547 rs76770287 chr14:35487210 C/A cg05294307 chr14:35346193 BAZ1A -0.51 -5.48 -0.32 1.01e-7 Psoriasis; CESC trans rs208520 0.789 rs9351549 chr6:66871851 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -12.67 -0.61 4.31e-29 Exhaled nitric oxide output; CESC cis rs9487051 0.676 rs9398193 chr6:109593134 G/T cg01475377 chr6:109611718 NA -0.44 -6.99 -0.39 2.19e-11 Reticulocyte fraction of red cells; CESC cis rs9549260 0.709 rs4943795 chr13:41173433 C/T cg21288729 chr13:41239152 FOXO1 -0.5 -5.2 -0.3 4e-7 Red blood cell count; CESC cis rs2204008 0.594 rs11531211 chr12:37998007 T/G cg26384229 chr12:38710491 ALG10B -0.55 -7.79 -0.43 1.49e-13 Bladder cancer; CESC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg23161317 chr6:28129485 ZNF389 -0.52 -6.62 -0.38 1.94e-10 Depression; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25845374 chr2:119981187 STEAP3 -0.37 -6.15 -0.35 2.83e-9 Gambling; CESC cis rs7503807 0.967 rs4889867 chr17:78593058 C/T cg09596252 chr17:78655493 RPTOR 0.48 7.04 0.4 1.63e-11 Obesity; CESC cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg14416269 chr4:6271139 WFS1 0.46 7.76 0.43 1.79e-13 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs2228479 0.850 rs62056069 chr16:89912000 C/T cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs2290159 0.800 rs11128607 chr3:12673275 A/G cg23032965 chr3:12705835 RAF1 0.53 5.67 0.33 3.76e-8 Cholesterol, total; CESC cis rs16854884 0.632 rs1466941 chr3:143670131 A/G cg01302019 chr3:143689584 C3orf58 -0.35 -5.47 -0.32 1.06e-7 Economic and political preferences (feminism/equality); CESC cis rs6582630 0.519 rs11514372 chr12:38308613 T/G cg13010199 chr12:38710504 ALG10B 0.46 5.88 0.34 1.26e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs75804782 0.521 rs72993034 chr2:239385895 C/T cg18131467 chr2:239335373 ASB1 -0.73 -5.88 -0.34 1.23e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs4547160 0.606 rs10784329 chr12:63477676 C/T cg26727693 chr12:63544175 AVPR1A -0.35 -5.18 -0.3 4.48e-7 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07310536 chr10:103892743 PPRC1 -0.51 -6.58 -0.37 2.45e-10 Fibrinogen levels; CESC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg24531977 chr5:56204891 C5orf35 -0.87 -10.87 -0.56 5.43e-23 Initial pursuit acceleration; CESC cis rs16895831 0.549 rs12209281 chr6:42615451 G/A cg10605015 chr6:42532144 UBR2 -0.5 -5.52 -0.32 8.27e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CESC cis rs8058578 1.000 rs67456513 chr16:30714828 A/T cg02466173 chr16:30829666 NA -0.4 -6.36 -0.36 8.58e-10 Multiple myeloma; CESC cis rs5498 0.869 rs892188 chr19:10409793 A/G cg10604476 chr19:10403908 ICAM5 -0.46 -6.39 -0.37 7.31e-10 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg00166722 chr3:10149974 C3orf24 0.47 6.03 0.35 5.62e-9 Alzheimer's disease; CESC cis rs5758659 0.652 rs129857 chr22:42399686 C/T cg04733989 chr22:42467013 NAGA -0.45 -6.09 -0.35 3.87e-9 Cognitive function; CESC cis rs4969178 0.931 rs6501208 chr17:76395038 A/T cg20026190 chr17:76395443 PGS1 0.49 7.9 0.44 7.44e-14 HDL cholesterol levels; CESC cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.61 0.47 6.47e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2425143 1.000 rs73902914 chr20:34432882 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.8 -7.23 -0.41 5.31e-12 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17076397 chr5:10353763 MARCH6 0.55 6.06 0.35 4.69e-9 Gut microbiome composition (summer); CESC cis rs2072499 0.966 rs6427307 chr1:156190083 A/G cg25208724 chr1:156163844 SLC25A44 0.98 17.46 0.73 5.7200000000000004e-46 Testicular germ cell tumor; CESC cis rs7818688 0.697 rs57890591 chr8:95983130 G/A cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs5753618 0.504 rs7284622 chr22:31907985 G/A cg00478049 chr22:31556069 RNF185 -0.46 -5.59 -0.32 5.63e-8 Colorectal cancer; CESC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg12463550 chr7:65579703 CRCP 0.59 7.42 0.41 1.55e-12 Aortic root size; CESC cis rs601339 1.000 rs1798219 chr12:123180061 A/C cg11919336 chr12:123188078 GPR109A 0.48 6.49 0.37 4.12e-10 Adiponectin levels; CESC cis rs9325144 0.554 rs1906264 chr12:38739490 A/G cg26384229 chr12:38710491 ALG10B 0.56 8.09 0.45 2.12e-14 Morning vs. evening chronotype; CESC cis rs4704187 0.687 rs4621540 chr5:74371203 T/G cg03227963 chr5:74354835 NA 0.31 5.81 0.34 1.74e-8 Response to amphetamines; CESC cis rs4604732 0.527 rs79329288 chr1:247626513 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs12701220 0.522 rs1881116 chr7:1053958 C/T cg20821713 chr7:1055600 C7orf50 -0.46 -5.57 -0.32 6.32e-8 Bronchopulmonary dysplasia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg19586645 chr17:73266642 MIF4GD 0.49 6.61 0.38 2.14e-10 Systemic lupus erythematosus; CESC cis rs965513 0.524 rs1443432 chr9:100583195 C/T cg13688889 chr9:100608707 NA -0.53 -7.71 -0.43 2.49e-13 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); CESC cis rs9916302 0.752 rs12150047 chr17:37601755 A/G cg07936489 chr17:37558343 FBXL20 -0.91 -9.97 -0.52 4.37e-20 Glomerular filtration rate (creatinine); CESC cis rs4629710 0.592 rs13205441 chr6:131575069 G/A cg12606694 chr6:131520996 AKAP7 0.49 5.99 0.35 6.78e-9 Multiple myeloma (IgH translocation); CESC cis rs7586673 0.930 rs2884364 chr2:161977647 G/A cg16506815 chr2:162101123 NA 0.42 5.83 0.34 1.63e-8 Intelligence (multi-trait analysis); CESC cis rs10751667 0.666 rs7395267 chr11:962326 C/A cg06064525 chr11:970664 AP2A2 -0.47 -9.32 -0.5 4.88e-18 Alzheimer's disease (late onset); CESC cis rs1801251 1.000 rs1446311 chr2:233705071 G/A cg25237894 chr2:233734115 C2orf82 -0.46 -8.05 -0.44 2.73e-14 Coronary artery disease; CESC trans rs561341 1.000 rs8064843 chr17:30245744 A/G cg20587970 chr11:113659929 NA -0.85 -10.47 -0.54 1.04e-21 Hip circumference adjusted for BMI; CESC cis rs9322193 0.884 rs9397036 chr6:150172923 C/T cg07701084 chr6:150067640 NUP43 0.4 5.23 0.31 3.41e-7 Lung cancer; CESC cis rs2425143 1.000 rs79035779 chr20:34343004 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -7.55 -0.42 6.87e-13 Blood protein levels; CESC cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.48 -0.32 1.01e-7 Total body bone mineral density; CESC cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg26839252 chr6:160211577 TCP1;MRPL18 0.44 5.06 0.3 7.95e-7 Age-related macular degeneration (geographic atrophy); CESC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 -1.08 -11.42 -0.57 8.16e-25 Platelet count; CESC cis rs11690935 0.595 rs788171 chr2:172921832 A/G cg13550731 chr2:172543902 DYNC1I2 0.5 6.94 0.39 3e-11 Schizophrenia; CESC cis rs950776 0.518 rs55690619 chr15:78833612 A/G cg06917634 chr15:78832804 PSMA4 -0.78 -11.9 -0.59 1.92e-26 Sudden cardiac arrest; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08084737 chr7:43965691 URGCP;UBE2D4 -0.7 -8.83 -0.48 1.46e-16 Gut microbiome composition (summer); CESC cis rs2361718 0.500 rs4889818 chr17:78085228 A/G cg21238619 chr17:78079768 GAA -0.42 -6.1 -0.35 3.7e-9 Yeast infection; CESC cis rs2247341 0.894 rs61675353 chr4:1720794 T/G cg07465881 chr4:1713556 SLBP -0.52 -6.55 -0.37 2.94e-10 Hip circumference adjusted for BMI;Height; CESC cis rs6963495 0.745 rs73192153 chr7:105212418 A/T cg19920283 chr7:105172520 RINT1 0.7 6.36 0.36 8.94e-10 Bipolar disorder (body mass index interaction); CESC cis rs523522 0.962 rs10849758 chr12:120971149 C/T cg27279351 chr12:120934652 DYNLL1 0.69 9.11 0.49 2.02e-17 High light scatter reticulocyte count; CESC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg07507251 chr3:52567010 NT5DC2 -0.35 -5.62 -0.33 4.91e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg13770153 chr20:60521292 NA -0.44 -5.7 -0.33 3.2e-8 Body mass index; CESC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg20243544 chr17:37824526 PNMT -0.44 -5.47 -0.32 1.06e-7 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22163445 chr2:101618580 RPL31 0.55 6.02 0.35 5.84e-9 Gut microbiome composition (summer); CESC cis rs28829049 0.597 rs12566296 chr1:19498443 A/C cg13387374 chr1:19411106 UBR4 0.44 5.53 0.32 7.52e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg10673544 chr7:122321539 CADPS2 -0.53 -7.25 -0.41 4.48e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs1538970 1.000 rs1538970 chr1:45847562 G/A cg06784218 chr1:46089804 CCDC17 0.35 5.96 0.34 7.86e-9 Platelet count; CESC cis rs2952156 0.959 rs2934952 chr17:37832366 G/A cg00129232 chr17:37814104 STARD3 -0.71 -9.32 -0.5 4.89e-18 Asthma; CESC cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg27121462 chr16:89883253 FANCA -0.57 -7.1 -0.4 1.15e-11 Vitiligo; CESC cis rs477692 1.000 rs531572 chr10:131427569 A/G cg05714579 chr10:131428358 MGMT -0.55 -7.59 -0.42 5.38e-13 Response to temozolomide; CESC cis rs3008870 1.000 rs3008848 chr1:67379284 C/T cg02640540 chr1:67518911 SLC35D1 0.49 5.21 0.3 3.81e-7 Lymphocyte percentage of white cells; CESC cis rs116095464 0.558 rs28418643 chr5:240859 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.5 5.31 0.31 2.3e-7 Breast cancer; CESC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -9.02 -0.48 4.02e-17 Total body bone mineral density; CESC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg17724175 chr1:150552817 MCL1 0.44 7.23 0.41 5.25e-12 Tonsillectomy; CESC cis rs4889855 0.530 rs7209279 chr17:78598055 T/A cg16591659 chr17:78472290 NA -0.33 -5.25 -0.31 3.08e-7 Fractional excretion of uric acid; CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg17372223 chr3:52568218 NT5DC2 0.45 7.38 0.41 2.09e-12 Bipolar disorder; CESC cis rs1559088 0.847 rs10423531 chr19:33600140 T/C cg17764715 chr19:33622953 WDR88 0.48 6.2 0.36 2.2e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs8072100 0.875 rs62073966 chr17:45600013 T/A cg08085267 chr17:45401833 C17orf57 0.46 6.2 0.36 2.21e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg10792982 chr14:105748885 BRF1 -0.42 -5.69 -0.33 3.3e-8 Mean platelet volume;Platelet distribution width; CESC cis rs2832191 0.791 rs2832187 chr21:30485543 T/C cg24692254 chr21:30365293 RNF160 -0.8 -12.74 -0.62 2.64e-29 Dental caries; CESC cis rs2625529 0.586 rs7173626 chr15:72186926 C/A cg16672083 chr15:72433130 SENP8 0.36 5.35 0.31 1.91e-7 Red blood cell count; CESC cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg17366294 chr4:99064904 C4orf37 0.58 8.31 0.45 5.14e-15 Colonoscopy-negative controls vs population controls; CESC cis rs1707322 0.964 rs785499 chr1:46592420 G/A cg03146154 chr1:46216737 IPP -0.74 -9.64 -0.51 4.75e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 11.0 0.56 1.98e-23 Platelet count; CESC cis rs2404602 0.552 rs11634428 chr15:77084582 T/C cg00316803 chr15:76480434 C15orf27 0.42 5.64 0.33 4.39e-8 Blood metabolite levels; CESC cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg17366294 chr4:99064904 C4orf37 0.62 8.86 0.48 1.22e-16 Colonoscopy-negative controls vs population controls; CESC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg16049864 chr8:95962084 TP53INP1 -0.65 -11.59 -0.58 2.12e-25 Type 2 diabetes; CESC cis rs6502050 0.835 rs34620191 chr17:80149532 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.57 -0.37 2.59e-10 Life satisfaction; CESC cis rs4319547 1.000 rs7309390 chr12:123110422 A/G cg05707623 chr12:122985044 ZCCHC8 -0.6 -7.08 -0.4 1.29e-11 Body mass index; CESC trans rs62103177 0.810 rs62103189 chr18:77627815 G/A cg05926928 chr17:57297772 GDPD1 1.18 10.14 0.53 1.27e-20 Opioid sensitivity; CESC cis rs9894429 0.682 rs7406360 chr17:79591545 G/A cg13777783 chr17:79615861 NA -0.33 -5.23 -0.31 3.45e-7 Eye color traits; CESC cis rs2444240 1.000 rs494965 chr11:120053650 C/T cg04390734 chr11:120039366 NA -0.28 -5.15 -0.3 5.09e-7 Corneal curvature; CESC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.6 0.42 5.11e-13 Prudent dietary pattern; CESC cis rs10129255 0.518 rs28378320 chr14:107216845 T/C cg07958169 chr14:107095056 NA -0.61 -9.81 -0.52 1.35e-19 Kawasaki disease; CESC cis rs7582720 1.000 rs7560547 chr2:203757916 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.39 0.41 1.96e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs6500395 0.962 rs9941275 chr16:48573428 A/G cg04672837 chr16:48644449 N4BP1 0.49 6.13 0.35 3.14e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6748734 1.000 rs4675874 chr2:241819796 A/G cg07537917 chr2:241836409 C2orf54 0.27 5.95 0.34 8.64e-9 Urinary metabolites; CESC cis rs473651 0.935 rs541128 chr2:239336449 A/G cg18131467 chr2:239335373 ASB1 1.02 21.09 0.79 1.28e-58 Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10358816 chr4:83295331 HNRNPD 0.55 6.28 0.36 1.4e-9 Gut microbiome composition (summer); CESC cis rs919433 0.963 rs1896857 chr2:198164530 A/G cg10820045 chr2:198174542 NA -0.39 -5.71 -0.33 3.05e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC trans rs35110281 0.607 rs4819212 chr21:44977455 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 7.4 0.41 1.83e-12 Mean corpuscular volume; CESC cis rs9858542 0.953 rs35115732 chr3:49475155 T/C cg07274523 chr3:49395745 GPX1 0.66 8.1 0.45 2.07e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7188697 0.922 rs37057 chr16:58561954 T/C cg21335942 chr16:58549945 SETD6 0.46 5.41 0.32 1.4e-7 QT interval; CESC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg04944784 chr2:26401820 FAM59B -0.64 -7.21 -0.41 5.78e-12 Gut microbiome composition (summer); CESC cis rs60843830 0.928 rs55742348 chr2:217563 T/A cg00108164 chr2:264199 ACP1;SH3YL1 0.77 9.72 0.51 2.66e-19 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs709400 0.627 rs55859054 chr14:103953666 T/A cg12935359 chr14:103987150 CKB -0.5 -7.3 -0.41 3.36e-12 Body mass index; CESC cis rs7216064 1.000 rs12602655 chr17:65909442 A/G cg12091567 chr17:66097778 LOC651250 -0.8 -8.08 -0.44 2.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09721380 chr16:69140530 HAS3 -0.56 -6.38 -0.36 7.96e-10 Gut microbiome composition (summer); CESC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg23978390 chr7:1156363 C7orf50 0.58 7.93 0.44 6.02e-14 Longevity;Endometriosis; CESC cis rs9818758 0.607 rs35283189 chr3:49113668 T/C cg00383909 chr3:49044727 WDR6 0.92 6.59 0.38 2.35e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg00166722 chr3:10149974 C3orf24 0.48 5.98 0.34 7.06e-9 Alzheimer's disease; CESC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg12564285 chr5:131593104 PDLIM4 0.41 6.28 0.36 1.39e-9 Acylcarnitine levels; CESC cis rs116095464 0.681 rs10060016 chr5:241100 T/C cg10591111 chr5:226296 SDHA -0.52 -6.38 -0.36 7.94e-10 Breast cancer; CESC cis rs79349575 0.715 rs4793997 chr17:47019672 C/A cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs13191362 1.000 rs28360546 chr6:163210973 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.01 9.42 0.5 2.35e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs2880765 0.835 rs4344688 chr15:86043007 A/C cg10818794 chr15:86012489 AKAP13 -0.34 -5.26 -0.31 3.02e-7 Coronary artery disease; CESC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -8.09 -0.44 2.23e-14 Developmental language disorder (linguistic errors); CESC cis rs11997175 0.902 rs7462610 chr8:33693318 A/T ch.8.33884649F chr8:33765107 NA 0.61 7.75 0.43 1.91e-13 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14242958 chr11:101785693 KIAA1377;ANGPTL5 0.54 6.23 0.36 1.78e-9 Gut microbiome composition (summer); CESC cis rs6674176 0.628 rs2240447 chr1:44415415 C/T cg12908607 chr1:44402522 ARTN -0.46 -6.64 -0.38 1.75e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs35955747 0.902 rs5997938 chr22:31676992 A/G cg25791279 chr22:32026902 PISD -0.5 -5.96 -0.34 7.96e-9 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg09509183 chr1:209979624 IRF6 0.47 5.72 0.33 2.93e-8 Cleft lip with or without cleft palate; CESC cis rs11792861 0.926 rs72607171 chr9:111837776 T/C cg05043794 chr9:111880884 C9orf5 -0.41 -6.74 -0.38 9.83e-11 Menarche (age at onset); CESC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -6.17 -0.35 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24903794 chr1:220220036 EPRS -0.51 -6.53 -0.37 3.26e-10 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23495556 chr7:44836196 PPIA 0.62 7.35 0.41 2.45e-12 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18504358 chr14:23340787 LRP10 0.51 6.61 0.38 2.15e-10 Gut microbiota (bacterial taxa); CESC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg24562669 chr7:97807699 LMTK2 0.52 7.69 0.43 2.85e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs2952156 0.959 rs2941504 chr17:37830900 A/G cg00129232 chr17:37814104 STARD3 -0.72 -9.62 -0.51 5.62e-19 Asthma; CESC cis rs7639513 0.767 rs7648488 chr3:12708946 T/C cg23032965 chr3:12705835 RAF1 0.76 10.86 0.55 5.83e-23 Itch intensity from mosquito bite; CESC cis rs847577 0.748 rs940431 chr7:97716495 C/T cg21770322 chr7:97807741 LMTK2 0.64 10.52 0.54 7.29e-22 Breast cancer; CESC cis rs9303280 0.806 rs4795395 chr17:37962987 T/A cg19468946 chr17:37922297 IKZF3 -0.41 -5.66 -0.33 3.9e-8 Self-reported allergy; CESC cis rs3087591 1.000 rs7226006 chr17:29650656 A/G cg24425628 chr17:29625626 OMG;NF1 -0.47 -5.82 -0.34 1.68e-8 Hip circumference; CESC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg10541313 chr22:46663664 TTC38 0.63 5.26 0.31 2.94e-7 LDL cholesterol;Cholesterol, total; CESC trans rs11722228 0.522 rs62286604 chr4:10131161 A/G cg26043149 chr18:55253948 FECH 1.01 12.66 0.61 4.83e-29 Gout;Urate levels;Serum uric acid levels; CESC cis rs7621025 0.500 rs1965107 chr3:136648643 T/A cg15507776 chr3:136538369 TMEM22 0.74 8.92 0.48 7.86e-17 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs748404 0.676 rs4401024 chr15:43650335 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.54 8.25 0.45 7.26e-15 Lung cancer; CESC cis rs7927771 0.839 rs59360790 chr11:47669175 T/C cg05585544 chr11:47624801 NA -0.41 -6.48 -0.37 4.55e-10 Subjective well-being; CESC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -6.63 -0.38 1.85e-10 Bipolar disorder; CESC trans rs997295 0.570 rs11632574 chr15:67852405 A/C cg05081167 chr6:156967138 NA 0.27 6.05 0.35 4.99e-9 Motion sickness; CESC cis rs3820068 0.581 rs68052904 chr1:15916714 T/C cg16988262 chr1:15930761 NA 0.34 5.38 0.31 1.61e-7 Systolic blood pressure; CESC cis rs9915657 0.870 rs759499 chr17:70133177 C/T cg06234051 chr17:70120541 SOX9 -0.41 -5.97 -0.34 7.75e-9 Thyroid hormone levels; CESC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg21251018 chr6:28226885 NKAPL 0.37 6.21 0.36 2.04e-9 Cardiac Troponin-T levels; CESC trans rs7980799 0.935 rs10844582 chr12:33560873 A/G cg26384229 chr12:38710491 ALG10B -0.52 -6.69 -0.38 1.29e-10 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg26408565 chr15:76604113 ETFA -0.43 -6.18 -0.36 2.37e-9 Blood metabolite levels; CESC cis rs7539409 0.651 rs6576953 chr1:84316946 A/G cg10977910 chr1:84465055 TTLL7 0.78 7.37 0.41 2.21e-12 Alzheimer's disease; CESC cis rs7927592 0.672 rs10501398 chr11:68331715 C/G cg01657329 chr11:68192670 LRP5 0.49 6.64 0.38 1.72e-10 Total body bone mineral density; CESC cis rs2180341 1.000 rs4895822 chr6:127642703 T/C cg24812749 chr6:127587940 RNF146 1.07 15.4 0.69 1.16e-38 Breast cancer; CESC cis rs55871839 0.684 rs10095333 chr8:59815629 G/A cg07426533 chr8:59803705 TOX -0.5 -7.39 -0.41 1.87e-12 Pneumonia; CESC cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg03433033 chr1:76189801 ACADM -0.8 -12.69 -0.61 3.85e-29 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3806843 0.735 rs801185 chr5:140068869 A/G cg16179182 chr5:140090404 VTRNA1-1 0.39 5.11 0.3 6.21e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2204008 0.715 rs11525003 chr12:38332359 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.9 0.56 4.29e-23 Bladder cancer; CESC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg06028605 chr16:24865363 SLC5A11 -0.54 -8.07 -0.44 2.39e-14 Intelligence (multi-trait analysis); CESC cis rs6991838 0.584 rs4737747 chr8:66519259 C/T cg13398993 chr8:66546079 ARMC1 -0.46 -5.45 -0.32 1.14e-7 Intelligence (multi-trait analysis); CESC cis rs6424115 0.800 rs2229583 chr1:24200983 C/T cg10978503 chr1:24200527 CNR2 0.31 6.02 0.35 5.84e-9 Immature fraction of reticulocytes; CESC cis rs6087990 1.000 rs1007123 chr20:31345840 G/A cg13636640 chr20:31349939 DNMT3B 0.91 15.84 0.7 3.34e-40 Ulcerative colitis; CESC cis rs4481887 0.927 rs4279879 chr1:248486475 A/G cg00666640 chr1:248458726 OR2T12 0.36 6.17 0.35 2.56e-9 Common traits (Other); CESC cis rs2361718 0.521 rs2361724 chr17:78099114 G/A cg21238619 chr17:78079768 GAA -0.38 -5.63 -0.33 4.51e-8 Yeast infection; CESC cis rs4704187 0.687 rs6858969 chr5:74379281 T/C cg03227963 chr5:74354835 NA 0.32 5.95 0.34 8.68e-9 Response to amphetamines; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25616684 chr1:38478508 UTP11L -0.48 -6.41 -0.37 6.55e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7584330 0.737 rs937392 chr2:238367130 C/T cg14458575 chr2:238380390 NA 0.62 8.43 0.46 2.19e-15 Prostate cancer; CESC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg18252515 chr7:66147081 NA 0.46 5.96 0.34 8.03e-9 Aortic root size; CESC cis rs28830936 0.510 rs11070349 chr15:42085017 A/C cg17847044 chr15:42102381 MAPKBP1 -0.45 -7.97 -0.44 4.8e-14 Diastolic blood pressure; CESC cis rs763121 0.719 rs9610995 chr22:39057763 C/T cg14440974 chr22:39074834 NA -0.4 -5.5 -0.32 9.03e-8 Menopause (age at onset); CESC trans rs3942852 0.550 rs1113480 chr11:48058313 G/T cg03929089 chr4:120376271 NA -0.62 -7.5 -0.42 9.35e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs287982 0.932 rs58521916 chr2:9966470 C/T cg10881225 chr2:9984929 TAF1B 0.41 5.2 0.3 4.01e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs16854884 0.580 rs7615861 chr3:143860822 A/G cg06585982 chr3:143692056 C3orf58 0.43 5.39 0.31 1.59e-7 Economic and political preferences (feminism/equality); CESC cis rs2274273 0.870 rs8023197 chr14:55767395 G/T cg04306507 chr14:55594613 LGALS3 0.32 6.17 0.35 2.53e-9 Protein biomarker; CESC cis rs2573652 0.674 rs11630619 chr15:100543367 G/A cg00587665 chr15:100533223 ADAMTS17 -0.41 -6.75 -0.38 9.15e-11 Height; CESC cis rs6967385 0.704 rs17149929 chr7:12406080 A/T cg06484146 chr7:12443880 VWDE 0.37 6.13 0.35 3.17e-9 Response to taxane treatment (placlitaxel); CESC cis rs763014 0.833 rs916415 chr16:632115 G/A cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC cis rs4692589 0.581 rs12646523 chr4:170944698 C/T cg19918862 chr4:170955249 NA 0.44 5.86 0.34 1.35e-8 Anxiety disorder; CESC cis rs7819412 0.749 rs11991118 chr8:10939273 A/C cg21775007 chr8:11205619 TDH 0.36 5.24 0.31 3.29e-7 Triglycerides; CESC cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg05564831 chr3:52568323 NT5DC2 -0.36 -5.6 -0.33 5.46e-8 Electroencephalogram traits; CESC cis rs9399135 0.967 rs7741515 chr6:135374368 C/G cg24558204 chr6:135376177 HBS1L -0.5 -6.77 -0.38 8.11e-11 Red blood cell count; CESC cis rs11577318 0.853 rs2276712 chr1:26627478 T/C cg19743891 chr1:26644573 UBXN11;CD52 -0.28 -5.05 -0.3 8.22e-7 Granulocyte percentage of myeloid white cells; CESC cis rs2637266 0.905 rs1978925 chr10:78399879 C/T cg18941641 chr10:78392320 NA 0.44 8.42 0.46 2.48e-15 Pulmonary function; CESC cis rs12893668 0.703 rs7148456 chr14:104028270 C/T cg24130564 chr14:104152367 KLC1 0.47 6.2 0.36 2.16e-9 Reticulocyte count; CESC trans rs66573146 0.572 rs55740475 chr4:6954092 C/G cg07817883 chr1:32538562 TMEM39B 1.2 8.35 0.46 3.81e-15 Granulocyte percentage of myeloid white cells; CESC cis rs2289583 0.544 rs6495132 chr15:75255322 C/T cg14664628 chr15:75095509 CSK 0.47 5.57 0.32 6.28e-8 Systemic lupus erythematosus; CESC cis rs1499614 0.803 rs1796229 chr7:66119661 G/A cg12463550 chr7:65579703 CRCP 0.74 5.71 0.33 3.03e-8 Gout; CESC cis rs8002861 0.765 rs12868462 chr13:44453480 C/T cg19180546 chr13:44453867 C13orf31;CCDC122 -0.46 -5.84 -0.34 1.5e-8 Leprosy; CESC cis rs4481887 0.741 rs6682957 chr1:248535639 T/G cg26353448 chr1:248524236 OR2T4 -0.4 -5.6 -0.33 5.41e-8 Common traits (Other); CESC cis rs727563 0.593 rs132770 chr22:42017264 A/G cg06481639 chr22:41940642 POLR3H 0.62 6.27 0.36 1.47e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs7560272 0.723 rs1052161 chr2:73828538 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -7.18 -0.4 6.95e-12 Schizophrenia; CESC cis rs9649213 0.614 rs4236537 chr7:97996593 T/C cg09267113 chr7:98030324 BAIAP2L1 -0.45 -6.07 -0.35 4.46e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1801251 0.778 rs709934 chr2:233733352 A/G cg25237894 chr2:233734115 C2orf82 -0.49 -8.62 -0.47 6.2e-16 Coronary artery disease; CESC cis rs763121 0.853 rs3788544 chr22:39064966 C/T cg21395723 chr22:39101663 GTPBP1 0.42 5.18 0.3 4.45e-7 Menopause (age at onset); CESC cis rs962856 1.000 rs6755797 chr2:67598633 G/A cg09028215 chr2:67624308 ETAA1 -0.41 -5.42 -0.32 1.33e-7 Pancreatic cancer; CESC cis rs7264396 0.635 rs2024854 chr20:34511189 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -11.07 -0.56 1.17e-23 Total cholesterol levels; CESC trans rs6818288 0.778 rs77441057 chr4:30077134 T/C cg12528397 chr3:62933670 NA 0.42 6.13 0.35 3.2e-9 Obesity-related traits; CESC cis rs6733011 0.508 rs4851173 chr2:99520608 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.11 -0.3 6.13e-7 Bipolar disorder; CESC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg06577658 chr19:46296270 DMWD 0.49 5.86 0.34 1.37e-8 Coronary artery disease; CESC trans rs76747430 0.528 rs5750913 chr22:40640285 A/G cg02581963 chr10:102133317 C10orf75 0.5 6.47 0.37 4.7e-10 Facial morphology (factor 20); CESC cis rs6964587 1.000 rs10281556 chr7:91660053 C/T cg17063962 chr7:91808500 NA -0.56 -7.9 -0.44 7.64e-14 Breast cancer; CESC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg19468946 chr17:37922297 IKZF3 -0.39 -5.08 -0.3 7.08e-7 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19016110 chr17:36981717 CCDC49 0.56 6.58 0.37 2.55e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21926875 chr2:47596410 EPCAM -0.44 -6.01 -0.35 6.23e-9 Fibrinogen levels; CESC cis rs2204008 0.837 rs11514225 chr12:38076270 G/A cg26384229 chr12:38710491 ALG10B 0.74 10.75 0.55 1.31e-22 Bladder cancer; CESC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg24829409 chr8:58192753 C8orf71 -0.67 -7.99 -0.44 4.08e-14 Developmental language disorder (linguistic errors); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg08413153 chr17:46185283 SNX11 -0.44 -6.47 -0.37 4.71e-10 Vertical cup-disc ratio; CESC cis rs77741769 0.529 rs2893876 chr12:121245158 T/C cg02419362 chr12:121203948 SPPL3 0.34 5.55 0.32 6.87e-8 Mean corpuscular volume; CESC cis rs9911578 1.000 rs302854 chr17:56683612 G/A cg05425664 chr17:57184151 TRIM37 -0.51 -7.21 -0.4 6.03e-12 Intelligence (multi-trait analysis); CESC cis rs959260 1.000 rs9892325 chr17:73394449 A/C cg20590849 chr17:73267439 MIF4GD -0.6 -6.77 -0.38 8.44e-11 Systemic lupus erythematosus; CESC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg02574844 chr11:5959923 NA -0.48 -7.13 -0.4 9.35e-12 DNA methylation (variation); CESC cis rs9815354 0.812 rs73073326 chr3:41834195 G/T cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05070332 chr2:56411072 CCDC85A 0.52 6.02 0.35 5.75e-9 Gut microbiome composition (summer); CESC cis rs9987353 0.620 rs34455383 chr8:9066458 C/T cg15556689 chr8:8085844 FLJ10661 -0.59 -6.43 -0.37 5.93e-10 Recombination measurement; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16528926 chr11:94823603 ENDOD1 0.45 6.43 0.37 5.86e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs763121 0.853 rs138705 chr22:39133803 C/T cg06544989 chr22:39130855 UNC84B 0.47 8.16 0.45 1.33e-14 Menopause (age at onset); CESC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg26939375 chr7:64535504 NA 0.75 10.17 0.53 1.03e-20 Aortic root size; CESC cis rs11122272 0.735 rs2491405 chr1:231513431 C/A cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.46 -0.46 1.88e-15 Intelligence (multi-trait analysis); CESC cis rs1707322 1.000 rs6676982 chr1:46275401 A/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2243480 1.000 rs387676 chr7:65598220 C/T cg13147721 chr7:65941812 NA -0.99 -9.4 -0.5 2.68e-18 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06616775 chr2:202316682 STRADB;TRAK2 0.55 6.02 0.35 5.88e-9 Gut microbiome composition (summer); CESC cis rs6968419 0.755 rs17138483 chr7:115893845 A/C cg02561103 chr7:115862891 TES -0.4 -5.26 -0.31 2.92e-7 Intraocular pressure; CESC cis rs35110281 0.807 rs2838328 chr21:45023234 G/C cg04455712 chr21:45112962 RRP1B 0.41 6.19 0.36 2.3e-9 Mean corpuscular volume; CESC cis rs1322639 0.614 rs9689800 chr6:169572945 T/A cg04662567 chr6:169592167 NA 0.4 5.64 0.33 4.36e-8 Pulse pressure; CESC cis rs10791323 0.604 rs2723605 chr11:133711241 C/G cg06766960 chr11:133703094 NA -0.41 -5.77 -0.33 2.24e-8 Childhood ear infection; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15929201 chr5:31531945 RNASEN;C5orf22 -0.42 -6.1 -0.35 3.79e-9 Gambling; CESC cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg25019033 chr10:957182 NA -0.57 -6.43 -0.37 6e-10 Eosinophil percentage of granulocytes; CESC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg19163074 chr7:65112434 INTS4L2 0.44 5.53 0.32 7.83e-8 Aortic root size; CESC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg14393609 chr7:65229607 NA 0.53 7.22 0.41 5.48e-12 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14819838 chr17:14140124 CDRT15 0.32 6.13 0.35 3.14e-9 Gambling; CESC cis rs11750568 0.935 rs10070609 chr5:178524969 T/C cg10208897 chr5:178548229 ADAMTS2 0.37 5.25 0.31 3.17e-7 Height; CESC cis rs35082559 1 rs35082559 chr2:23896606 CA/C cg14009731 chr2:24150123 ATAD2B 0.52 5.37 0.31 1.71e-7 Granulocyte percentage of myeloid white cells; CESC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg11247378 chr22:39784982 NA -0.63 -9.37 -0.5 3.38e-18 Intelligence (multi-trait analysis); CESC cis rs4888262 0.526 rs7201105 chr16:74590603 A/G cg01733217 chr16:74700730 RFWD3 0.81 11.35 0.57 1.39e-24 Testicular germ cell tumor; CESC cis rs10911232 0.507 rs10797816 chr1:182998486 A/T ch.1.3577855R chr1:183094577 LAMC1 0.8 12.2 0.6 1.85e-27 Hypertriglyceridemia; CESC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg22535103 chr8:58192502 C8orf71 -1.06 -13.13 -0.63 1.17e-30 Developmental language disorder (linguistic errors); CESC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg03538708 chr1:25844672 NA 0.37 5.69 0.33 3.32e-8 Erythrocyte sedimentation rate; CESC cis rs2732480 0.500 rs7315820 chr12:48598938 C/T cg24011408 chr12:48396354 COL2A1 0.43 6.11 0.35 3.5e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs4835473 0.897 rs11931330 chr4:144891961 G/A cg25736465 chr4:144833511 NA 0.39 5.99 0.35 6.96e-9 Immature fraction of reticulocytes; CESC cis rs7809950 1.000 rs10273733 chr7:107258121 A/G cg23024343 chr7:107201750 COG5 0.44 5.88 0.34 1.26e-8 Coronary artery disease; CESC cis rs2816062 0.813 rs6698315 chr1:18895806 A/G cg18795169 chr1:18902165 NA -0.91 -17.81 -0.74 3.44e-47 Urate levels in lean individuals; CESC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 10.93 0.56 3.38e-23 Platelet count; CESC cis rs2204008 0.623 rs1315348 chr12:38163044 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.92 -0.34 9.92e-9 Bladder cancer; CESC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg03609598 chr5:56110824 MAP3K1 -0.53 -5.62 -0.33 4.78e-8 Initial pursuit acceleration; CESC cis rs9905704 0.918 rs694720 chr17:56708019 T/C cg12560992 chr17:57184187 TRIM37 0.59 7.02 0.4 1.86e-11 Testicular germ cell tumor; CESC cis rs8062405 1.000 rs62037371 chr16:28890131 C/A cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg16423265 chr20:60697137 LSM14B -0.42 -6.08 -0.35 4.12e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs35520189 0.591 rs11690185 chr2:113698136 C/T cg06156847 chr2:113672199 IL1F7 0.37 5.27 0.31 2.87e-7 Obstructive sleep apnea trait (apnea hypopnea index); CESC cis rs7107174 1.000 rs2510036 chr11:77966788 G/T cg02023728 chr11:77925099 USP35 0.44 5.76 0.33 2.33e-8 Testicular germ cell tumor; CESC cis rs11676348 0.791 rs4133195 chr2:218951245 A/G cg00012203 chr2:219082015 ARPC2 0.52 6.83 0.39 5.92e-11 Ulcerative colitis; CESC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25485126 chr19:13873471 CCDC130 -0.56 -6.75 -0.38 9.03e-11 Gut microbiome composition (summer); CESC trans rs10411161 0.702 rs2867319 chr19:52397160 T/C cg22319618 chr22:45562946 NUP50 -0.77 -7.77 -0.43 1.78e-13 Breast cancer; CESC cis rs3862260 0.509 rs3795663 chr1:120165187 G/A cg16322792 chr1:120165303 ZNF697 0.58 10.95 0.56 2.82e-23 Systemic lupus erythematosus; CESC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs9300255 0.830 rs28413626 chr12:123861452 G/A cg00376283 chr12:123451042 ABCB9 -0.66 -7.42 -0.41 1.57e-12 Neutrophil percentage of white cells; CESC cis rs11608355 0.545 rs12823587 chr12:109896390 A/G cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs2933343 0.951 rs796862 chr3:128593040 G/A cg25356066 chr3:128598488 ACAD9 0.57 7.19 0.4 6.81e-12 IgG glycosylation; CESC cis rs10927875 0.894 rs10927878 chr1:16319957 C/T cg21385522 chr1:16154831 NA -0.6 -7.57 -0.42 6.04e-13 Dilated cardiomyopathy; CESC trans rs2121875 0.667 rs56338120 chr5:44215482 C/T cg09056876 chr6:156718398 NA -0.47 -6.09 -0.35 4.01e-9 Prostate cancer; CESC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg22105103 chr4:187893119 NA 0.51 7.6 0.42 5.05e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs2629540 0.889 rs4962402 chr10:126459114 T/G cg08799069 chr10:126477246 METTL10 -0.66 -9.2 -0.49 1.13e-17 Cocaine dependence; CESC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg12463550 chr7:65579703 CRCP -0.54 -6.97 -0.39 2.44e-11 Aortic root size; CESC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg08736216 chr1:53307985 ZYG11A -0.39 -6.65 -0.38 1.65e-10 Monocyte count; CESC cis rs651907 0.557 rs7629753 chr3:101371922 C/T cg12386194 chr3:101231763 SENP7 -0.44 -5.6 -0.33 5.35e-8 Colorectal cancer; CESC cis rs6502050 0.835 rs67149434 chr17:80128007 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.97e-7 Life satisfaction; CESC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg06505273 chr16:24850292 NA 0.5 6.06 0.35 4.66e-9 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs10426930 0.700 rs8106479 chr19:5003940 G/C cg18115693 chr19:4968519 KDM4B -0.42 -5.34 -0.31 2.05e-7 Monocyte percentage of white cells; CESC cis rs6032067 0.929 rs1997892 chr20:43810961 A/T cg10761708 chr20:43804764 PI3 0.56 6.97 0.39 2.54e-11 Blood protein levels; CESC cis rs7397814 0.558 rs4764447 chr12:9579109 C/T cg08919224 chr12:9569744 NA -0.47 -6.03 -0.35 5.51e-9 IgG glycosylation; CESC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg19099843 chr7:12443191 VWDE -0.49 -5.3 -0.31 2.47e-7 Coronary artery disease; CESC cis rs2637266 0.783 rs1660908 chr10:78494856 T/C cg18941641 chr10:78392320 NA 0.43 8.46 0.46 1.83e-15 Pulmonary function; CESC cis rs1550582 1.000 rs4909827 chr8:135517576 C/T cg17885191 chr8:135476712 NA 0.63 7.35 0.41 2.53e-12 Educational attainment; CESC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg23281280 chr6:28129359 ZNF389 0.6 8.29 0.45 5.57e-15 Depression; CESC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.09e-8 Alzheimer's disease; CESC cis rs17826219 0.568 rs9898097 chr17:29072672 T/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Body mass index; CESC cis rs4595586 0.525 rs11611705 chr12:39426828 C/T cg13010199 chr12:38710504 ALG10B 0.43 5.17 0.3 4.55e-7 Morning vs. evening chronotype; CESC cis rs7539409 0.833 rs2057083 chr1:84269942 T/G cg10977910 chr1:84465055 TTLL7 0.66 5.92 0.34 9.98e-9 Alzheimer's disease; CESC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg07677032 chr17:61819896 STRADA 0.48 6.47 0.37 4.64e-10 Prudent dietary pattern; CESC cis rs10779751 0.734 rs2791657 chr1:11128001 A/G cg08854313 chr1:11322531 MTOR 0.77 10.41 0.54 1.73e-21 Body mass index; CESC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg04025307 chr7:1156635 C7orf50 0.49 7.97 0.44 4.59e-14 Longevity;Endometriosis; CESC cis rs829883 1.000 rs2908843 chr12:98889332 C/G cg25150519 chr12:98850993 NA -0.7 -9.62 -0.51 5.38e-19 Colorectal adenoma (advanced); CESC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg10691866 chr7:65817282 TPST1 0.31 5.33 0.31 2.06e-7 Aortic root size; CESC cis rs6831352 0.819 rs896992 chr4:100002372 C/T cg13256891 chr4:100009986 ADH5 0.67 8.06 0.44 2.68e-14 Alcohol dependence; CESC cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg05347473 chr6:146136440 FBXO30 0.77 9.78 0.51 1.78e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg14393609 chr7:65229607 NA 0.51 6.96 0.39 2.61e-11 Aortic root size; CESC cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg03467027 chr4:99064603 C4orf37 0.46 5.81 0.34 1.8e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg09699651 chr6:150184138 LRP11 0.41 5.13 0.3 5.51e-7 Lung cancer; CESC cis rs11864453 0.713 rs7190995 chr16:72124157 A/G cg01557791 chr16:72042693 DHODH -0.46 -5.92 -0.34 9.98e-9 Fibrinogen levels; CESC cis rs7264396 0.635 rs6060696 chr20:34522060 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.58 6.99 0.39 2.22e-11 Total cholesterol levels; CESC cis rs9611565 0.840 rs9607799 chr22:41777558 A/G cg17376030 chr22:41985996 PMM1 0.6 6.45 0.37 5.42e-10 Vitiligo; CESC cis rs6496667 0.865 rs13329288 chr15:90897451 C/T cg22089800 chr15:90895588 ZNF774 0.57 5.76 0.33 2.27e-8 Rheumatoid arthritis; CESC cis rs2012796 0.913 rs8010181 chr14:81820125 T/C cg02996355 chr14:81879375 NA 0.48 5.77 0.33 2.22e-8 Night sleep phenotypes; CESC cis rs7727544 0.735 rs274568 chr5:131713578 C/T cg07395648 chr5:131743802 NA 0.48 6.41 0.37 6.73e-10 Blood metabolite levels; CESC cis rs4077515 0.874 rs4498662 chr9:139290251 C/G cg14169450 chr9:139327907 INPP5E 0.4 5.81 0.34 1.79e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs7851660 0.809 rs7022148 chr9:100660824 T/C cg13688889 chr9:100608707 NA -0.62 -8.87 -0.48 1.11e-16 Strep throat; CESC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg24562669 chr7:97807699 LMTK2 0.48 7.1 0.4 1.13e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs9486715 0.867 rs4839828 chr6:96863326 G/A cg06623918 chr6:96969491 KIAA0776 0.9 14.0 0.65 1.07e-33 Headache; CESC cis rs7582720 1.000 rs72926779 chr2:203805929 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.38 0.41 1.99e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs1707322 0.721 rs12043945 chr1:46106922 T/A cg05343316 chr1:45956843 TESK2 0.51 6.22 0.36 1.91e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15598754 chr1:21551903 ECE1 -0.61 -6.94 -0.39 3.01e-11 Gut microbiome composition (summer); CESC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 21.54 0.8 3.65e-60 Prudent dietary pattern; CESC cis rs6546550 1.000 rs6546550 chr2:70038232 C/G cg02498382 chr2:70120550 SNRNP27 -0.4 -6.9 -0.39 3.75e-11 Prevalent atrial fibrillation; CESC cis rs796364 0.951 rs36086821 chr2:201067436 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.61 5.71 0.33 3.07e-8 Schizophrenia; CESC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg05313129 chr8:58192883 C8orf71 -0.53 -5.27 -0.31 2.86e-7 Developmental language disorder (linguistic errors); CESC cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg13628971 chr7:2884303 GNA12 0.41 5.49 0.32 9.4e-8 Height; CESC trans rs11159647 0.636 rs4899848 chr14:84731303 A/T cg19838074 chr2:242149865 ANO7 0.41 6.01 0.35 6.06e-9 Alzheimer's disease; CESC cis rs2236918 1.000 rs2526701 chr1:242018427 T/C cg17736920 chr1:242011382 EXO1 0.73 9.84 0.52 1.16e-19 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11021810 chr14:89720620 FOXN3 -0.6 -6.81 -0.39 6.68e-11 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg13206674 chr6:150067644 NUP43 0.43 6.31 0.36 1.16e-9 Lung cancer; CESC cis rs295140 0.526 rs295113 chr2:201197816 C/G cg23649088 chr2:200775458 C2orf69 0.47 6.36 0.36 8.87e-10 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01452438 chr16:4303710 NA 0.55 6.11 0.35 3.54e-9 Gut microbiome composition (summer); CESC cis rs2742234 0.590 rs2435339 chr10:43642173 G/C cg15436174 chr10:43711423 RASGEF1A -0.48 -5.61 -0.33 5.11e-8 Hirschsprung disease; CESC cis rs7267979 0.966 rs2500417 chr20:25383287 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -16.62 -0.71 5.52e-43 Liver enzyme levels (alkaline phosphatase); CESC cis rs2072732 0.861 rs3795262 chr1:2938697 A/C cg03976712 chr1:2946727 NA 0.35 5.66 0.33 3.92e-8 Plateletcrit; CESC cis rs3862030 0.503 rs6584505 chr10:104254412 C/A cg22532475 chr10:104410764 TRIM8 -0.35 -5.92 -0.34 9.74e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CESC cis rs863345 0.967 rs4528114 chr1:158467713 T/C cg12129480 chr1:158549410 OR10X1 -0.32 -6.27 -0.36 1.42e-9 Pneumococcal bacteremia; CESC cis rs12500824 0.564 rs72657832 chr4:77319523 A/G cg20311846 chr4:77356250 SHROOM3 0.39 7.46 0.42 1.24e-12 Coronary artery disease; CESC cis rs1461503 0.868 rs7126785 chr11:122839564 C/A cg27398637 chr11:122830231 C11orf63 -0.55 -8.32 -0.45 4.77e-15 Menarche (age at onset); CESC trans rs4424809 0.614 rs74521004 chr13:85572247 A/G cg05918002 chr17:5019452 ZNF232 -0.64 -6.06 -0.35 4.77e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg12386194 chr3:101231763 SENP7 -0.49 -6.14 -0.35 3.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg14500267 chr11:67383377 NA -0.35 -5.48 -0.32 1e-7 Mean corpuscular volume; CESC trans rs1493916 0.905 rs4239383 chr18:31401066 T/C cg27147174 chr7:100797783 AP1S1 -0.52 -6.93 -0.39 3.22e-11 Life satisfaction; CESC cis rs9309473 0.950 rs7567585 chr2:73751966 G/A cg20560298 chr2:73613845 ALMS1 -0.45 -6.13 -0.35 3.13e-9 Metabolite levels; CESC cis rs6088590 0.561 rs11167239 chr20:33140472 G/A cg08999081 chr20:33150536 PIGU 0.7 12.47 0.61 2.17e-28 Coronary artery disease; CESC cis rs9325144 0.532 rs12812406 chr12:38719802 G/A cg26384229 chr12:38710491 ALG10B -0.58 -7.99 -0.44 4.15e-14 Morning vs. evening chronotype; CESC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg26314531 chr2:26401878 FAM59B -0.85 -9.23 -0.49 8.65e-18 Gut microbiome composition (summer); CESC cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg15605315 chr1:45957053 TESK2 0.42 5.3 0.31 2.42e-7 High light scatter reticulocyte count; CESC cis rs35306767 0.909 rs12264390 chr10:959111 T/C cg25019033 chr10:957182 NA -0.64 -8.06 -0.44 2.66e-14 Eosinophil percentage of granulocytes; CESC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC cis rs7116495 0.609 rs2276384 chr11:71701523 A/G cg07596299 chr11:71824057 C11orf51 0.76 5.21 0.3 3.86e-7 Severe influenza A (H1N1) infection; CESC cis rs7917772 0.560 rs11595170 chr10:104339851 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.4 -5.4 -0.31 1.49e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs7903847 0.642 rs10786344 chr10:99165975 T/C cg20016023 chr10:99160130 RRP12 -0.3 -5.12 -0.3 5.91e-7 Granulocyte percentage of myeloid white cells; CESC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg24549020 chr5:56110836 MAP3K1 -0.68 -7.76 -0.43 1.8e-13 Initial pursuit acceleration; CESC cis rs4689388 0.609 rs1046319 chr4:6304286 C/T cg00701064 chr4:6280414 WFS1 0.56 7.32 0.41 2.89e-12 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs4843747 0.636 rs11864872 chr16:88105966 A/G cg26811252 chr16:29126840 RRN3P2 0.67 9.47 0.5 1.58e-18 Menopause (age at onset); CESC cis rs644799 0.648 rs1016031 chr11:95473365 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.5 -6.91 -0.39 3.54e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6570726 0.935 rs110289 chr6:145865176 C/G cg05347473 chr6:146136440 FBXO30 0.48 6.45 0.37 5.27e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01092528 chr4:76861103 NAAA -0.41 -6.11 -0.35 3.58e-9 Gambling; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23260190 chr10:101419318 ENTPD7 -0.44 -6.47 -0.37 4.78e-10 Fibrinogen levels; CESC cis rs7617773 0.780 rs13067450 chr3:48337206 C/T cg11946769 chr3:48343235 NME6 0.89 12.11 0.6 3.63e-27 Coronary artery disease; CESC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg10074409 chr1:209979377 IRF6 0.36 5.75 0.33 2.46e-8 Cleft lip with or without cleft palate; CESC cis rs2637266 1.000 rs12251434 chr10:78345468 C/A cg18941641 chr10:78392320 NA 0.43 7.93 0.44 5.97e-14 Pulmonary function; CESC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg02569458 chr12:86230093 RASSF9 0.49 7.21 0.4 5.91e-12 Major depressive disorder; CESC cis rs7940866 0.903 rs11222411 chr11:130838682 A/G cg12179176 chr11:130786555 SNX19 0.6 8.26 0.45 7e-15 Schizophrenia; CESC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg13012494 chr21:47604986 C21orf56 0.49 6.57 0.37 2.71e-10 Testicular germ cell tumor; CESC cis rs7927592 0.871 rs12360903 chr11:68236314 C/A cg20283391 chr11:68216788 NA -0.61 -7.29 -0.41 3.64e-12 Total body bone mineral density; CESC cis rs2841277 0.509 rs11850949 chr14:105408827 A/C cg15352829 chr14:105391018 PLD4 -0.6 -10.38 -0.54 2.05e-21 Rheumatoid arthritis; CESC cis rs72634258 0.842 rs7545677 chr1:8165619 C/T cg00042356 chr1:8021962 PARK7 0.46 5.05 0.3 8.29e-7 Inflammatory bowel disease; CESC cis rs2797160 0.967 rs1954360 chr6:126001064 A/G cg05901451 chr6:126070800 HEY2 -0.45 -6.62 -0.38 1.95e-10 Endometrial cancer; CESC cis rs7116495 1.000 rs671681 chr11:71782812 T/C cg10381502 chr11:71823885 C11orf51 -0.68 -5.48 -0.32 9.68e-8 Severe influenza A (H1N1) infection; CESC cis rs6456156 0.792 rs2039321 chr6:167516299 C/T cg23791538 chr6:167370224 RNASET2 -0.4 -5.11 -0.3 6.28e-7 Primary biliary cholangitis; CESC cis rs6088580 0.634 rs6059875 chr20:33086090 T/G cg06115741 chr20:33292138 TP53INP2 0.45 5.74 0.33 2.53e-8 Glomerular filtration rate (creatinine); CESC cis rs524281 0.861 rs4013917 chr11:65926185 A/G cg14036092 chr11:66035641 RAB1B -0.56 -5.57 -0.32 6.24e-8 Electroencephalogram traits; CESC cis rs7586673 0.930 rs2884364 chr2:161977647 G/A cg21518248 chr2:162101506 NA 0.46 6.24 0.36 1.73e-9 Intelligence (multi-trait analysis); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg06808967 chr3:38178743 ACAA1;MYD88 -0.46 -6.28 -0.36 1.37e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg22535103 chr8:58192502 C8orf71 -1.06 -13.36 -0.63 1.72e-31 Developmental language disorder (linguistic errors); CESC cis rs9287719 0.967 rs6432112 chr2:10744874 A/G cg00105475 chr2:10696890 NA -0.38 -5.69 -0.33 3.3e-8 Prostate cancer; CESC trans rs150063 0.572 rs150070 chr16:13245367 C/G cg18016365 chr4:47033634 GABRB1 -0.33 -6.11 -0.35 3.61e-9 Lung function (FEV1/FVC); CESC cis rs8092503 1.000 rs2014237 chr18:52494583 T/C cg12377874 chr18:52495404 RAB27B -0.33 -5.75 -0.33 2.4e-8 Childhood body mass index; CESC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg14703610 chr5:56206110 C5orf35 0.45 5.84 0.34 1.5e-8 Breast cancer;Breast cancer (early onset); CESC cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC cis rs2952156 0.920 rs12150298 chr17:37834541 T/C cg20243544 chr17:37824526 PNMT 0.62 8.21 0.45 9.64e-15 Asthma; CESC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg17372223 chr3:52568218 NT5DC2 0.52 8.16 0.45 1.32e-14 Electroencephalogram traits; CESC cis rs7937682 0.961 rs4936682 chr11:111629743 T/G cg22437258 chr11:111473054 SIK2 -0.6 -6.53 -0.37 3.27e-10 Primary sclerosing cholangitis; CESC cis rs589448 0.902 rs315138 chr12:69764850 A/T cg22834771 chr12:69754056 YEATS4 -0.57 -7.68 -0.43 3.15e-13 Cerebrospinal fluid biomarker levels; CESC cis rs3008870 0.755 rs1024230 chr1:67512920 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.56 7.05 0.4 1.58e-11 Lymphocyte percentage of white cells; CESC cis rs2302190 0.882 rs7210714 chr17:56675666 A/C cg25885038 chr17:56607967 SEPT4 -0.4 -5.45 -0.32 1.17e-7 Vitamin D levels; CESC cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg05340658 chr4:99064831 C4orf37 0.82 12.99 0.62 3.34e-30 Colonoscopy-negative controls vs population controls; CESC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg18904891 chr8:8559673 CLDN23 0.64 7.22 0.41 5.45e-12 Obesity-related traits; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg10451977 chr15:45507901 NA -0.49 -6.29 -0.36 1.33e-9 Breast cancer;Type 2 diabetes; CESC cis rs72781680 0.611 rs72781699 chr2:24277709 G/A cg06627628 chr2:24431161 ITSN2 -0.65 -6.29 -0.36 1.31e-9 Lymphocyte counts; CESC cis rs1256061 0.564 rs1256043 chr14:64734282 A/G cg23250157 chr14:64679961 SYNE2 0.53 7.64 0.42 4.09e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs910316 0.967 rs175505 chr14:75529619 C/T cg08847533 chr14:75593920 NEK9 -0.97 -18.2 -0.75 1.38e-48 Height; CESC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg05368731 chr17:41323189 NBR1 0.78 10.62 0.55 3.59e-22 Menopause (age at onset); CESC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg02569458 chr12:86230093 RASSF9 0.51 7.64 0.42 3.9e-13 Major depressive disorder; CESC cis rs67072384 1.000 rs72964181 chr11:72440124 C/G cg04827223 chr11:72435913 ARAP1 -0.66 -5.98 -0.34 7.28e-9 Alloimmunization response to red blood cell transfusion in sickle cell anemia; CESC cis rs12425791 0.500 rs34336285 chr12:721769 G/T cg26654770 chr12:740100 NINJ2 -0.52 -5.45 -0.32 1.14e-7 Stroke;Paclitaxel disposition in epithelial ovarian cancer; CESC cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.46 7.83 0.43 1.14e-13 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08450091 chr3:82857215 NA -0.56 -6.5 -0.37 3.9e-10 Gut microbiome composition (summer); CESC cis rs748404 0.660 rs2602141 chr15:43724646 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.57 7.58 0.42 5.77e-13 Lung cancer; CESC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg18301423 chr5:131593218 PDLIM4 -0.4 -5.73 -0.33 2.76e-8 Breast cancer; CESC cis rs6867032 0.570 rs13166888 chr5:1982966 G/T cg26168224 chr5:2018326 NA -0.79 -11.71 -0.58 8.14e-26 Gut microbiome composition (winter); CESC cis rs4132509 1.000 rs3766673 chr1:243720473 T/C cg21452805 chr1:244014465 NA 0.44 5.38 0.31 1.63e-7 RR interval (heart rate); CESC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg11041457 chr3:52719354 GNL3;PBRM1 -0.5 -7.27 -0.41 4e-12 Bipolar disorder; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg16296724 chr12:123237325 DENR 0.47 7.16 0.4 8.07e-12 Vertical cup-disc ratio; CESC cis rs34779708 0.931 rs11010125 chr10:35502953 A/G cg04310649 chr10:35416472 CREM -0.52 -6.34 -0.36 1e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs228437 0.913 rs1535117 chr6:134911816 G/A cg24504307 chr6:134963096 NA 0.49 5.65 0.33 4.23e-8 Melanoma; CESC cis rs11676348 0.935 rs4674250 chr2:218977531 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.45 -5.82 -0.34 1.7e-8 Ulcerative colitis; CESC cis rs1707322 0.717 rs2275086 chr1:46085879 C/G cg05343316 chr1:45956843 TESK2 -0.53 -6.58 -0.37 2.49e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7712401 0.502 rs30066 chr5:122293702 A/G cg19412675 chr5:122181750 SNX24 0.46 5.42 0.32 1.37e-7 Mean platelet volume; CESC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.58 6.46 0.37 5.04e-10 IgG glycosylation; CESC cis rs9768139 0.935 rs7800718 chr7:158121878 G/A cg06219351 chr7:158114137 PTPRN2 0.45 7.0 0.39 2.13e-11 Calcium levels; CESC cis rs66573146 1.000 rs7686186 chr4:6986094 C/T cg00086871 chr4:6988644 TBC1D14 1.11 6.36 0.36 8.97e-10 Granulocyte percentage of myeloid white cells; CESC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg17949981 chr6:28129498 ZNF389 -0.45 -5.51 -0.32 8.35e-8 Depression; CESC cis rs2204008 0.652 rs11520002 chr12:38022179 G/T cg26384229 chr12:38710491 ALG10B 0.75 10.72 0.55 1.61e-22 Bladder cancer; CESC cis rs644799 0.664 rs603625 chr11:95554283 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.77 11.04 0.56 1.47e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs11711311 0.955 rs12636240 chr3:113391282 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.69 9.04 0.49 3.38e-17 IgG glycosylation; CESC cis rs7107174 1.000 rs4492844 chr11:78026516 A/G cg02023728 chr11:77925099 USP35 0.46 6.34 0.36 9.69e-10 Testicular germ cell tumor; CESC cis rs9287719 0.967 rs6432119 chr2:10753687 A/T cg02196655 chr2:10830764 NOL10 -0.37 -5.69 -0.33 3.39e-8 Prostate cancer; CESC cis rs7264396 0.563 rs2425088 chr20:34303902 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.88 -10.64 -0.55 3.06e-22 Total cholesterol levels; CESC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg12412775 chr1:25698385 RHCE -0.32 -5.7 -0.33 3.13e-8 Erythrocyte sedimentation rate; CESC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg19318889 chr4:1322082 MAEA 0.44 6.02 0.35 5.83e-9 Longevity; CESC cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg03709012 chr19:19516395 GATAD2A 0.98 15.06 0.68 1.85e-37 Tonsillectomy; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12540815 chr19:45394385 TOMM40 0.52 6.71 0.38 1.21e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07367563 chr1:151032068 CDC42SE1;MLLT11 0.59 6.96 0.39 2.73e-11 Gut microbiome composition (summer); CESC cis rs7618501 1.000 rs7431106 chr3:49808374 G/A cg24308560 chr3:49941425 MST1R -0.51 -6.99 -0.39 2.28e-11 Intelligence (multi-trait analysis); CESC cis rs10504229 0.953 rs59034808 chr8:58185337 T/C cg22535103 chr8:58192502 C8orf71 -0.88 -11.43 -0.57 7.29e-25 Developmental language disorder (linguistic errors); CESC cis rs1801251 1.000 rs283484 chr2:233646505 A/G cg08000102 chr2:233561755 GIGYF2 0.65 9.33 0.5 4.55e-18 Coronary artery disease; CESC trans rs1728785 0.818 rs11075684 chr16:68582365 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.35 0.41 2.44e-12 Ulcerative colitis; CESC cis rs1506636 1.000 rs676755 chr7:123439082 A/G cg03229431 chr7:123269106 ASB15 -0.43 -5.58 -0.32 5.86e-8 Plateletcrit;Platelet count; CESC cis rs6582630 0.555 rs11610015 chr12:38508856 A/G cg26384229 chr12:38710491 ALG10B 0.65 9.72 0.51 2.77e-19 Drug-induced liver injury (flucloxacillin); CESC cis rs7520050 0.807 rs5021934 chr1:46109304 A/G cg03146154 chr1:46216737 IPP -0.52 -7.04 -0.4 1.68e-11 Red blood cell count;Reticulocyte count; CESC cis rs9291683 0.509 rs10939671 chr4:10050815 T/C cg00071950 chr4:10020882 SLC2A9 0.79 13.76 0.65 7.23e-33 Bone mineral density; CESC trans rs629535 0.911 rs627382 chr8:70014081 C/T cg21567404 chr3:27674614 NA -0.91 -10.9 -0.56 4.13e-23 Dupuytren's disease; CESC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg18301423 chr5:131593218 PDLIM4 0.38 5.5 0.32 8.83e-8 Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03127034 chr6:41561307 FOXP4 -0.52 -6.25 -0.36 1.62e-9 Gut microbiome composition (summer); CESC cis rs1800469 1.000 rs2241712 chr19:41869756 C/T cg08477640 chr19:41863820 B9D2 0.67 9.24 0.49 8.62e-18 Colorectal cancer; CESC cis rs7147624 0.938 rs10467734 chr14:65913947 C/T cg03016385 chr14:66212404 NA -0.49 -5.04 -0.3 8.51e-7 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs11583043 1.000 rs6675353 chr1:101459625 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 5.56 0.32 6.53e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs4523957 0.548 rs7213756 chr17:2098339 C/A cg16513277 chr17:2031491 SMG6 -0.49 -6.31 -0.36 1.15e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs735396 1.000 rs2259816 chr12:121435587 A/C cg25281562 chr12:121454272 C12orf43 -0.38 -5.04 -0.3 8.8e-7 N-glycan levels; CESC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.61 8.4 0.46 2.82e-15 Menarche (age at onset); CESC cis rs17253792 0.749 rs45458197 chr14:56145018 A/T cg01858014 chr14:56050164 KTN1 -0.97 -7.54 -0.42 7.36e-13 Putamen volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10942059 chr7:105460221 ATXN7L1 0.47 6.28 0.36 1.37e-9 Fibrinogen levels; CESC cis rs244293 0.831 rs1948000 chr17:53147716 T/G cg19360675 chr17:53046073 COX11;STXBP4 0.39 5.04 0.3 8.6e-7 Menarche (age at onset); CESC cis rs10788972 0.873 rs11206283 chr1:54576639 A/C cg25741118 chr1:54482237 LDLRAD1 0.21 5.18 0.3 4.4e-7 Parkinson disease and lewy body pathology; CESC cis rs8114671 0.527 rs6088650 chr20:33514465 C/T cg24642439 chr20:33292090 TP53INP2 -0.44 -5.38 -0.31 1.67e-7 Height; CESC cis rs1728785 1.000 rs1094282 chr16:68577260 G/A cg02972257 chr16:68554789 NA -0.55 -6.31 -0.36 1.17e-9 Ulcerative colitis; CESC cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg02297831 chr4:17616191 MED28 0.66 8.05 0.44 2.75e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg05657792 chr17:6899758 ALOX12 0.41 7.05 0.4 1.58e-11 Tonsillectomy; CESC cis rs238295 0.631 rs6038205 chr20:5549073 T/A cg24001556 chr20:5591874 RP5-1022P6.2 -0.46 -5.11 -0.3 6.12e-7 Occipital cortical area (total cortical area interaction); CESC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg00166722 chr3:10149974 C3orf24 0.53 6.65 0.38 1.64e-10 Alzheimer's disease; CESC cis rs9486719 0.947 rs11153071 chr6:97039741 G/A cg18709589 chr6:96969512 KIAA0776 -0.5 -5.42 -0.32 1.31e-7 Migraine;Coronary artery disease; CESC cis rs2228479 0.850 rs62054224 chr16:89892071 C/T cg14709524 chr16:89940631 TCF25 0.89 6.41 0.37 6.61e-10 Skin colour saturation; CESC cis rs611744 0.647 rs647907 chr8:109251374 T/C cg21045802 chr8:109455806 TTC35 0.48 5.89 0.34 1.17e-8 Dupuytren's disease; CESC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.62 0.38 1.94e-10 Prudent dietary pattern; CESC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.38 0.54 2.06e-21 Prudent dietary pattern; CESC cis rs11030122 0.702 rs10835340 chr11:3960420 A/G cg18678763 chr11:4115507 RRM1 0.5 6.61 0.38 2.08e-10 Mean platelet volume;Platelet distribution width; CESC cis rs12458462 0.892 rs35928863 chr18:77438956 A/G cg23301140 chr18:77439876 CTDP1 0.55 7.26 0.41 4.23e-12 Monocyte count; CESC cis rs4704187 0.687 rs4404660 chr5:74422210 T/C cg03227963 chr5:74354835 NA 0.31 5.7 0.33 3.22e-8 Response to amphetamines; CESC cis rs8017423 0.607 rs10142482 chr14:90848280 G/T cg14092571 chr14:90743983 NA 0.42 6.24 0.36 1.71e-9 Mortality in heart failure; CESC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 -0.3 -5.56 -0.32 6.56e-8 Electroencephalogram traits; CESC cis rs9549367 0.789 rs3861720 chr13:113906097 A/G cg18105134 chr13:113819100 PROZ -0.68 -8.25 -0.45 7.53e-15 Platelet distribution width; CESC cis rs9487051 0.752 rs9372209 chr6:109601684 T/C cg12927641 chr6:109611667 NA -0.36 -5.24 -0.31 3.24e-7 Reticulocyte fraction of red cells; CESC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg11494091 chr17:61959527 GH2 0.73 12.71 0.62 3.32e-29 Prudent dietary pattern; CESC cis rs11098499 0.697 rs4560394 chr4:120313435 T/G cg09307838 chr4:120376055 NA 0.92 12.59 0.61 8.63e-29 Corneal astigmatism; CESC cis rs4919694 0.901 rs12264456 chr10:104830634 C/T cg04362960 chr10:104952993 NT5C2 0.79 7.08 0.4 1.27e-11 Arsenic metabolism; CESC cis rs858239 0.600 rs6461691 chr7:23139345 G/A cg23682824 chr7:23144976 KLHL7 0.51 6.82 0.39 6.16e-11 Cerebrospinal fluid biomarker levels; CESC cis rs7809950 0.678 rs7788330 chr7:106985648 G/T cg23024343 chr7:107201750 COG5 -0.52 -6.73 -0.38 1.02e-10 Coronary artery disease; CESC cis rs738322 0.726 rs5750561 chr22:38595260 A/T cg25457927 chr22:38595422 NA 0.36 6.83 0.39 5.91e-11 Cutaneous nevi; CESC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg24531977 chr5:56204891 C5orf35 0.69 9.17 0.49 1.4e-17 Initial pursuit acceleration; CESC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg03388025 chr16:89894329 SPIRE2 0.42 8.07 0.44 2.41e-14 Vitiligo; CESC cis rs17253792 0.822 rs17253730 chr14:56157911 A/G cg01858014 chr14:56050164 KTN1 -0.97 -7.59 -0.42 5.34e-13 Putamen volume; CESC cis rs796364 0.806 rs11679658 chr2:200923081 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.84 -7.66 -0.43 3.54e-13 Schizophrenia; CESC cis rs9300255 0.507 rs1615350 chr12:123650335 C/T cg00376283 chr12:123451042 ABCB9 0.66 9.14 0.49 1.7e-17 Neutrophil percentage of white cells; CESC cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg00033643 chr7:134001901 SLC35B4 0.41 5.22 0.31 3.68e-7 Mean platelet volume; CESC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg04287289 chr16:89883240 FANCA -0.8 -13.71 -0.64 1.04e-32 Vitiligo; CESC cis rs738322 0.934 rs133019 chr22:38573035 A/G cg25457927 chr22:38595422 NA -0.35 -6.41 -0.37 6.52e-10 Cutaneous nevi; CESC cis rs6693567 0.545 rs1260403 chr1:150303666 A/G cg09579323 chr1:150459698 TARS2 0.5 6.24 0.36 1.75e-9 Migraine; CESC cis rs3820068 0.581 rs58425551 chr1:15922518 A/G cg16988262 chr1:15930761 NA 0.35 5.69 0.33 3.38e-8 Systolic blood pressure; CESC cis rs7336332 0.574 rs9512699 chr13:28029896 G/A cg22138327 chr13:27999177 GTF3A -0.52 -5.04 -0.3 8.48e-7 Weight; CESC cis rs1153858 1.000 rs7169587 chr15:45640379 A/G cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs2204008 0.774 rs4534658 chr12:38246783 G/A cg26384229 chr12:38710491 ALG10B 0.66 9.37 0.5 3.3e-18 Bladder cancer; CESC cis rs6060717 0.536 rs11697024 chr20:34546500 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.58 0.32 5.8e-8 Hip circumference adjusted for BMI; CESC cis rs4561483 0.514 rs33639 chr16:11989499 A/C cg08843971 chr16:11963173 GSPT1 -0.54 -7.54 -0.42 7.41e-13 Testicular germ cell tumor; CESC cis rs6582630 0.537 rs35336822 chr12:38346251 T/C cg26384229 chr12:38710491 ALG10B 0.7 10.48 0.54 9.91e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs1045714 0.895 rs73043180 chr7:2645972 C/T cg20813462 chr7:2646259 IQCE 0.63 5.53 0.32 7.86e-8 Urate levels in lean individuals; CESC cis rs6690583 0.524 rs12030837 chr1:85519383 A/G cg22488158 chr1:85528044 WDR63 -0.59 -5.61 -0.33 5.05e-8 Serum sulfate level; CESC cis rs45535039 1.000 rs7114172 chr11:119116603 T/C cg16724696 chr11:118992527 HINFP 0.4 5.16 0.3 4.82e-7 Plateletcrit; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04205485 chr20:32399084 CHMP4B 0.53 6.03 0.35 5.53e-9 Gut microbiome composition (summer); CESC cis rs6693567 0.565 rs10888578 chr1:150260993 A/G cg09579323 chr1:150459698 TARS2 -0.44 -5.57 -0.32 6.11e-8 Migraine; CESC cis rs826838 0.754 rs2387920 chr12:38626351 A/G cg13010199 chr12:38710504 ALG10B 0.53 6.89 0.39 4.13e-11 Heart rate; CESC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg24829409 chr8:58192753 C8orf71 -0.76 -9.93 -0.52 5.87e-20 Developmental language disorder (linguistic errors); CESC cis rs11098499 0.863 rs3775841 chr4:120425777 A/C cg24375607 chr4:120327624 NA 0.44 5.22 0.31 3.58e-7 Corneal astigmatism; CESC cis rs3096299 0.606 rs4785674 chr16:89536613 A/G cg02187348 chr16:89574699 SPG7 0.44 5.34 0.31 2e-7 Multiple myeloma (IgH translocation); CESC cis rs12142240 0.738 rs17361749 chr1:46806480 C/T cg00530320 chr1:46809349 NSUN4 0.59 7.85 0.43 1.02e-13 Menopause (age at onset); CESC cis rs7824557 0.527 rs2572369 chr8:11238597 C/T cg21775007 chr8:11205619 TDH -0.52 -7.77 -0.43 1.79e-13 Retinal vascular caliber; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01530317 chr1:3566579 WDR8 0.55 6.29 0.36 1.34e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2440129 0.611 rs1042356 chr17:6902743 G/A cg08946332 chr17:6899888 ALOX12 0.44 6.48 0.37 4.45e-10 Tonsillectomy; CESC cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg00409905 chr10:38381863 ZNF37A -0.46 -6.03 -0.35 5.39e-9 Extrinsic epigenetic age acceleration; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg11355319 chr5:89825117 LYSMD3 0.48 6.57 0.37 2.59e-10 Weight; CESC cis rs148803332 1 rs148803332 chr17:65958250 CAAAAGAAA/C cg12091567 chr17:66097778 LOC651250 0.71 8.03 0.44 3.18e-14 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes; CESC cis rs225245 0.817 rs1634684 chr17:33941051 A/G cg05299278 chr17:33885742 SLFN14 0.38 5.52 0.32 8.21e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08984405 chr17:685103 RNMTL1;GLOD4 -0.68 -7.77 -0.43 1.72e-13 Gut microbiome composition (summer); CESC cis rs7100689 0.646 rs1538823 chr10:82088040 C/A cg00277334 chr10:82204260 NA -0.6 -7.96 -0.44 4.91e-14 Post bronchodilator FEV1; CESC cis rs1497406 0.744 rs4661718 chr1:16505908 C/T cg20430773 chr1:16534157 ARHGEF19 0.33 5.32 0.31 2.22e-7 Gamma gluatamyl transferase levels;Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs11574514 1.000 rs8052287 chr16:67865073 C/T cg01866162 chr16:67596514 CTCF 0.94 5.69 0.33 3.28e-8 Crohn's disease; CESC cis rs3820068 0.581 rs56128111 chr1:15928948 T/G cg13390004 chr1:15929781 NA 0.35 5.58 0.32 5.83e-8 Systolic blood pressure; CESC cis rs921968 0.510 rs2577761 chr2:219462500 G/A cg02176678 chr2:219576539 TTLL4 0.48 8.45 0.46 2e-15 Mean corpuscular hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03368399 chr8:22102556 POLR3D;MIR320A 0.5 6.16 0.35 2.66e-9 Gut microbiome composition (summer); CESC cis rs17253792 0.545 rs12894368 chr14:56025178 C/A cg01858014 chr14:56050164 KTN1 -0.88 -6.42 -0.37 6.38e-10 Putamen volume; CESC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg18758796 chr5:131593413 PDLIM4 0.48 6.97 0.39 2.55e-11 Acylcarnitine levels; CESC cis rs3820068 0.581 rs78175477 chr1:15948091 C/G cg17385448 chr1:15911702 AGMAT 0.42 6.83 0.39 5.64e-11 Systolic blood pressure; CESC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg11890956 chr21:40555474 PSMG1 1.03 15.61 0.69 2.04e-39 Cognitive function; CESC cis rs9814567 1.000 rs1534026 chr3:134284767 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.45 -6.07 -0.35 4.51e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg18765753 chr7:1198926 ZFAND2A -0.41 -5.67 -0.33 3.66e-8 Longevity;Endometriosis; CESC cis rs55692411 0.537 rs71326904 chr3:49991060 C/T cg24308560 chr3:49941425 MST1R -0.53 -6.43 -0.37 6.09e-10 Intelligence (multi-trait analysis); CESC cis rs921968 0.619 rs1554623 chr2:219606177 C/T cg02176678 chr2:219576539 TTLL4 -0.46 -8.2 -0.45 1.07e-14 Mean corpuscular hemoglobin concentration; CESC cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg24110177 chr3:50126178 RBM5 0.58 8.17 0.45 1.28e-14 Body mass index; CESC cis rs60154123 0.505 rs76101197 chr1:210044089 T/C cg21951975 chr1:209979733 IRF6 0.6 6.65 0.38 1.62e-10 Coronary artery disease; CESC cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg21918786 chr6:109611834 NA -0.38 -5.63 -0.33 4.59e-8 Reticulocyte fraction of red cells; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg19757253 chr2:32853039 TTC27 -0.45 -6.33 -0.36 1.02e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs72781680 1.000 rs12616250 chr2:24211550 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.58 0.32 6.04e-8 Lymphocyte counts; CESC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg24733560 chr20:60626293 TAF4 0.44 6.24 0.36 1.68e-9 Body mass index; CESC cis rs963731 0.649 rs10439459 chr2:39236983 G/T cg04010122 chr2:39346883 SOS1 -0.72 -5.65 -0.33 4.12e-8 Corticobasal degeneration; CESC cis rs870825 0.616 rs7678900 chr4:185635249 A/G cg04058563 chr4:185651563 MLF1IP 0.64 6.83 0.39 5.66e-11 Blood protein levels; CESC cis rs9325144 0.723 rs1586373 chr12:39181582 G/A cg26384229 chr12:38710491 ALG10B -0.51 -7.23 -0.41 5.23e-12 Morning vs. evening chronotype; CESC cis rs67311347 1.000 rs9848083 chr3:40466979 A/G cg09455208 chr3:40491958 NA -0.44 -7.7 -0.43 2.67e-13 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11687679 chr13:37573611 EXOSC8;ALG5 0.58 6.76 0.38 8.82e-11 Gut microbiome composition (summer); CESC cis rs9916302 0.904 rs11654018 chr17:37703740 C/T cg20243544 chr17:37824526 PNMT -0.51 -6.41 -0.37 6.5e-10 Glomerular filtration rate (creatinine); CESC cis rs4253772 0.637 rs6008339 chr22:46650846 C/T cg09491104 chr22:46646882 C22orf40 -0.59 -9.15 -0.49 1.58e-17 LDL cholesterol;Cholesterol, total; CESC cis rs3020736 0.500 rs6002604 chr22:42493081 A/T cg15557168 chr22:42548783 NA 0.45 6.57 0.37 2.72e-10 Autism spectrum disorder or schizophrenia; CESC cis rs76878669 0.561 rs4930363 chr11:66169676 C/T cg18002602 chr11:66138449 SLC29A2 0.36 5.89 0.34 1.18e-8 Educational attainment (years of education); CESC cis rs2710642 0.544 rs10204410 chr2:62829979 G/T cg17519650 chr2:63277830 OTX1 0.49 6.47 0.37 4.69e-10 LDL cholesterol levels;LDL cholesterol; CESC cis rs1784581 0.588 rs10945792 chr6:162423484 C/T cg17173639 chr6:162384350 PARK2 0.57 8.68 0.47 4.23e-16 Itch intensity from mosquito bite; CESC cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg07636037 chr3:49044803 WDR6 0.6 7.17 0.4 7.33e-12 Menarche (age at onset); CESC cis rs67311347 0.544 rs67533651 chr3:40338367 T/A cg09455208 chr3:40491958 NA 0.36 6.35 0.36 9.37e-10 Renal cell carcinoma; CESC cis rs2115536 0.967 rs3826008 chr15:80189805 G/T cg00225070 chr15:80189496 MTHFS 0.61 8.58 0.47 7.87e-16 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC cis rs61776719 0.520 rs72661887 chr1:38416310 C/T cg17077180 chr1:38461687 NA 0.45 6.89 0.39 3.99e-11 Coronary artery disease; CESC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg16325326 chr1:53192061 ZYG11B 0.79 11.72 0.58 7.81e-26 Monocyte count; CESC cis rs6088580 0.602 rs6059834 chr20:33019299 A/G cg06115741 chr20:33292138 TP53INP2 0.48 6.14 0.35 3e-9 Glomerular filtration rate (creatinine); CESC cis rs453301 0.571 rs2929456 chr8:9083416 G/A cg17143192 chr8:8559678 CLDN23 -0.44 -5.35 -0.31 1.94e-7 Joint mobility (Beighton score); CESC cis rs1413885 0.516 rs6659883 chr1:65838618 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.46 5.95 0.34 8.55e-9 Anticoagulant levels; CESC cis rs3780486 0.874 rs10813955 chr9:33141791 C/T cg13443165 chr9:33130375 B4GALT1 0.45 6.49 0.37 4.1e-10 IgG glycosylation; CESC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg22535103 chr8:58192502 C8orf71 -0.84 -9.44 -0.5 2.04e-18 Developmental language disorder (linguistic errors); CESC cis rs1577917 0.771 rs2475790 chr6:86368068 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -7.3 -0.41 3.27e-12 Response to antipsychotic treatment; CESC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.4 0.54 1.76e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7937682 0.587 rs611607 chr11:111349765 C/T cg22437258 chr11:111473054 SIK2 0.42 5.21 0.3 3.75e-7 Primary sclerosing cholangitis; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg00986762 chr1:36107072 PSMB2 -0.49 -6.78 -0.38 7.75e-11 Height; CESC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg20151795 chr6:28129481 ZNF389 0.46 5.83 0.34 1.65e-8 Depression; CESC cis rs9796 0.621 rs2578655 chr15:41462809 T/G cg18705301 chr15:41695430 NDUFAF1 -0.48 -6.94 -0.39 3.01e-11 Menopause (age at onset); CESC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.03 -0.3 8.96e-7 Breast cancer; CESC cis rs6867032 0.958 rs4463207 chr5:2017118 G/T cg26168224 chr5:2018326 NA 0.95 19.24 0.76 3.09e-52 Gut microbiome composition (winter); CESC cis rs7107174 1.000 rs10793295 chr11:77996521 C/G cg02023728 chr11:77925099 USP35 -0.38 -5.43 -0.32 1.26e-7 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18364779 chr6:26104403 HIST1H4C -0.53 -6.07 -0.35 4.42e-9 Gut microbiome composition (summer); CESC cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg22823121 chr1:150693482 HORMAD1 -0.34 -5.07 -0.3 7.5e-7 Tonsillectomy; CESC cis rs863345 0.604 rs1342945 chr1:158512912 C/A cg12129480 chr1:158549410 OR10X1 -0.35 -7.1 -0.4 1.14e-11 Pneumococcal bacteremia; CESC cis rs35110281 0.837 rs2838342 chr21:45077865 G/A cg04455712 chr21:45112962 RRP1B 0.39 5.94 0.34 9e-9 Mean corpuscular volume; CESC cis rs7726839 0.561 rs4957050 chr5:579066 A/C cg09021430 chr5:549028 NA -0.44 -5.96 -0.34 8.23e-9 Obesity-related traits; CESC cis rs9640161 0.636 rs3735171 chr7:150033882 A/G cg10018233 chr7:150070692 REPIN1 0.49 7.38 0.41 2.09e-12 Blood protein levels;Circulating chemerin levels; CESC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg17554472 chr22:41940697 POLR3H -0.49 -5.05 -0.3 8.22e-7 Vitiligo; CESC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg01341218 chr17:43662625 NA -0.58 -7.66 -0.43 3.54e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.88e-10 Life satisfaction; CESC cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg00409905 chr10:38381863 ZNF37A -0.45 -5.98 -0.34 7.18e-9 Extrinsic epigenetic age acceleration; CESC cis rs34172651 0.545 rs8056132 chr16:24716348 A/G cg06028605 chr16:24865363 SLC5A11 0.38 6.04 0.35 5.1e-9 Intelligence (multi-trait analysis); CESC cis rs9863 0.828 rs11057412 chr12:124489142 G/C cg17562584 chr12:124393655 DNAH10 0.3 5.17 0.3 4.68e-7 White blood cell count; CESC cis rs2991971 0.782 rs10789463 chr1:45927848 C/A cg15605315 chr1:45957053 TESK2 -0.4 -5.56 -0.32 6.56e-8 High light scatter reticulocyte count; CESC cis rs12995491 0.933 rs7590305 chr2:88513131 C/T cg18490616 chr2:88469792 THNSL2 -0.5 -7.06 -0.4 1.49e-11 Response to metformin (IC50); CESC cis rs919433 0.963 rs1366837 chr2:198160501 T/C cg10820045 chr2:198174542 NA -0.43 -6.58 -0.37 2.48e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs6912958 0.781 rs9444512 chr6:88223397 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -5.27 -0.31 2.82e-7 Monocyte percentage of white cells; CESC cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg06636001 chr8:8085503 FLJ10661 0.51 6.17 0.35 2.61e-9 Neuroticism; CESC cis rs734999 0.549 rs867436 chr1:2523723 C/T cg20673091 chr1:2541236 MMEL1 0.42 6.92 0.39 3.48e-11 Ulcerative colitis; CESC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg27286337 chr10:134555280 INPP5A -0.61 -7.31 -0.41 3.25e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg16489826 chr6:160211363 TCP1;MRPL18 -0.83 -11.73 -0.58 7.13e-26 Age-related macular degeneration (geographic atrophy); CESC cis rs7119038 0.818 rs4936444 chr11:118743338 A/G cg19308663 chr11:118741387 NA -0.43 -5.19 -0.3 4.12e-7 Sjögren's syndrome; CESC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg13206674 chr6:150067644 NUP43 0.41 5.72 0.33 2.8e-8 Lung cancer; CESC cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg26408565 chr15:76604113 ETFA -0.42 -6.09 -0.35 3.92e-9 Blood metabolite levels; CESC trans rs8017423 0.740 rs8003095 chr14:90680643 A/T cg01911440 chr17:78818045 RPTOR -0.4 -6.03 -0.35 5.43e-9 Mortality in heart failure; CESC cis rs10883723 0.810 rs3781289 chr10:104244991 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.62 0.42 4.65e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs9815354 1.000 rs73069392 chr3:41787009 C/T cg03022575 chr3:42003672 ULK4 0.57 5.52 0.32 8.18e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs6484504 0.625 rs6484501 chr11:31373100 G/T cg14844989 chr11:31128820 NA 0.39 5.25 0.31 3.13e-7 Red blood cell count; CESC cis rs1144333 1.000 rs5745354 chr1:76275178 G/A cg03433033 chr1:76189801 ACADM -0.54 -5.59 -0.32 5.62e-8 Attention function in attention deficit hyperactive disorder; CESC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg24675658 chr1:53192096 ZYG11B 0.53 6.78 0.38 7.96e-11 Monocyte count; CESC cis rs7267979 1.000 rs6083804 chr20:25317060 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -18.7 -0.75 2.48e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs12995491 1.000 rs12995491 chr2:88527414 C/T cg04511125 chr2:88470314 THNSL2 0.48 7.03 0.4 1.74e-11 Response to metformin (IC50); CESC cis rs7592578 0.766 rs62181052 chr2:191387858 A/G cg10560079 chr2:191398806 TMEM194B -0.65 -5.46 -0.32 1.11e-7 Diastolic blood pressure; CESC cis rs7267979 0.966 rs454723 chr20:25438928 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.86 17.28 0.73 2.57e-45 Liver enzyme levels (alkaline phosphatase); CESC cis rs2455799 0.613 rs6795100 chr3:15793798 C/T cg16303742 chr3:15540471 COLQ -0.39 -6.14 -0.35 3.01e-9 Mean platelet volume; CESC cis rs6032067 0.641 rs761500 chr20:43772272 A/G cg10761708 chr20:43804764 PI3 -0.58 -6.47 -0.37 4.61e-10 Blood protein levels; CESC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.66 8.76 0.47 2.29e-16 Prudent dietary pattern; CESC cis rs8038465 1.000 rs8032727 chr15:73977336 A/G cg15420318 chr15:73925796 NPTN 0.44 6.23 0.36 1.81e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4253772 0.591 rs6007726 chr22:46650858 A/C cg10231785 chr22:46692440 CN5H6.4;GTSE1 0.48 5.11 0.3 6.16e-7 LDL cholesterol;Cholesterol, total; CESC cis rs1023500 0.573 rs1807494 chr22:42474138 C/G cg15557168 chr22:42548783 NA 0.45 6.5 0.37 3.87e-10 Schizophrenia; CESC cis rs3820068 0.603 rs67349836 chr1:15966176 T/C cg17385448 chr1:15911702 AGMAT 0.44 7.14 0.4 8.88e-12 Systolic blood pressure; CESC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg02462569 chr6:150064036 NUP43 -0.34 -5.06 -0.3 7.74e-7 Lung cancer; CESC cis rs6582630 0.519 rs4406888 chr12:38293312 A/C cg13010199 chr12:38710504 ALG10B 0.46 5.88 0.34 1.26e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs1568889 1.000 rs7933332 chr11:28036392 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.02 0.56 1.69e-23 Bipolar disorder; CESC cis rs10779751 0.770 rs2261434 chr1:11170131 A/C cg08854313 chr1:11322531 MTOR 0.84 12.06 0.6 5.27e-27 Body mass index; CESC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 10.96 0.56 2.75e-23 Platelet count; CESC cis rs6963495 0.818 rs73190187 chr7:105164401 A/T cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.52 0.46 1.18e-15 Menopause (age at onset); CESC cis rs8060686 0.623 rs7204208 chr16:68069416 A/G cg26727032 chr16:67993705 SLC12A4 -0.59 -8.16 -0.45 1.39e-14 HDL cholesterol;Metabolic syndrome; CESC cis rs1475911 0.708 rs8129075 chr21:43523430 G/T cg03240473 chr21:43526662 UMODL1;C21orf128 -0.54 -7.21 -0.41 5.73e-12 IgG glycosylation; CESC trans rs7740797 0.967 rs3757291 chr6:155124583 G/T cg08950929 chr16:58768327 GOT2 0.45 6.0 0.35 6.49e-9 Colorectal or endometrial cancer; CESC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg06456125 chr7:65229604 NA 0.44 5.6 0.33 5.44e-8 Aortic root size; CESC cis rs2832191 0.791 rs2832202 chr21:30501342 G/A cg24692254 chr21:30365293 RNF160 -0.8 -12.29 -0.6 9.16e-28 Dental caries; CESC cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg03467027 chr4:99064603 C4orf37 0.44 5.63 0.33 4.57e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9303401 0.615 rs7502342 chr17:56922629 C/A cg10487724 chr17:56770010 TEX14;RAD51C 1.01 12.45 0.61 2.57e-28 Cognitive test performance; CESC cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg23711669 chr6:146136114 FBXO30 0.93 12.43 0.61 2.96e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs76419734 0.558 rs10019217 chr4:106588509 C/T cg24545054 chr4:106630052 GSTCD;INTS12 0.73 9.54 0.51 9.69e-19 Post bronchodilator FEV1; CESC cis rs9527 0.614 rs4919691 chr10:104624475 A/C cg15744005 chr10:104629667 AS3MT -0.34 -5.34 -0.31 1.96e-7 Arsenic metabolism; CESC cis rs1697139 0.563 rs6859520 chr5:66529020 C/T cg11553311 chr5:66541588 NA 0.36 5.16 0.3 4.96e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21025089 chr22:42487122 NDUFA6 0.57 6.27 0.36 1.42e-9 Gut microbiome composition (summer); CESC cis rs7582720 0.943 rs115130739 chr2:203725677 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs1976403 0.633 rs1780324 chr1:21821757 A/G cg02390115 chr1:21767211 NBPF3 0.36 5.05 0.3 8.05e-7 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01457183 chr3:180707371 DNAJC19 0.59 6.7 0.38 1.23e-10 Gut microbiome composition (summer); CESC cis rs13392177 0.637 rs61041183 chr2:219056380 G/A cg00012203 chr2:219082015 ARPC2 0.73 9.91 0.52 6.93e-20 Pyoderma gangrenosum in inflammatory bowel disease; CESC cis rs6665290 0.836 rs56029302 chr1:227203390 G/A cg10327440 chr1:227177885 CDC42BPA -1.14 -25.05 -0.84 7.67e-72 Myeloid white cell count; CESC cis rs1348850 0.914 rs10497503 chr2:178371739 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.79 11.25 0.57 2.91e-24 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs17209837 0.607 rs4148811 chr7:87101486 T/G cg00919237 chr7:87102261 ABCB4 -0.51 -6.51 -0.37 3.66e-10 Gallbladder cancer; CESC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg00684032 chr4:1343700 KIAA1530 0.42 6.52 0.37 3.57e-10 Longevity; CESC cis rs10089 1.000 rs2409109 chr5:127461471 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.07 0.53 2.04e-20 Ileal carcinoids; CESC trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -8.39 -0.46 2.99e-15 Intelligence (multi-trait analysis); CESC cis rs7824557 0.564 rs2572386 chr8:11236975 A/G cg21775007 chr8:11205619 TDH -0.54 -8.05 -0.44 2.77e-14 Retinal vascular caliber; CESC cis rs1044826 0.642 rs1080371 chr3:139210894 C/T cg00490450 chr3:139108681 COPB2 0.43 5.34 0.31 2.03e-7 Obesity-related traits; CESC cis rs208520 0.874 rs208512 chr6:66943869 C/G cg07460842 chr6:66804631 NA -0.83 -9.92 -0.52 6.27e-20 Exhaled nitric oxide output; CESC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg02951883 chr7:2050386 MAD1L1 -0.46 -6.17 -0.35 2.57e-9 Bipolar disorder and schizophrenia; CESC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg12463550 chr7:65579703 CRCP -0.56 -7.2 -0.4 6.04e-12 Aortic root size; CESC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg26314531 chr2:26401878 FAM59B -0.6 -6.82 -0.39 6.24e-11 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26257210 chr1:6305348 HES3 -0.47 -6.66 -0.38 1.53e-10 Fibrinogen levels; CESC cis rs73001065 0.901 rs73004951 chr19:19695228 C/T cg03709012 chr19:19516395 GATAD2A 0.98 5.98 0.34 7.23e-9 LDL cholesterol; CESC cis rs12586317 0.534 rs1568200 chr14:35419592 C/T cg16230307 chr14:35515116 FAM177A1 0.9 10.77 0.55 1.1e-22 Psoriasis; CESC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg02891314 chr5:179741120 GFPT2 -0.7 -9.49 -0.5 1.4e-18 Height; CESC cis rs238295 0.805 rs1056244 chr20:5551034 G/C cg24001556 chr20:5591874 RP5-1022P6.2 -0.46 -5.11 -0.3 6.12e-7 Occipital cortical area (total cortical area interaction); CESC cis rs3015497 1.000 rs3015495 chr14:51114703 C/T cg26011998 chr14:51135199 SAV1 -0.41 -5.21 -0.3 3.89e-7 Mean platelet volume; CESC cis rs6087990 0.966 rs2377667 chr20:31346925 A/G cg13636640 chr20:31349939 DNMT3B 0.91 16.04 0.7 6.22e-41 Ulcerative colitis; CESC cis rs4849845 0.598 rs3889223 chr2:121024432 A/G cg24070213 chr2:121070622 NA 0.45 6.67 0.38 1.53e-10 Mean platelet volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19104112 chr7:39663043 RALA 0.54 6.0 0.35 6.4e-9 Gut microbiome composition (summer); CESC cis rs5769707 0.837 rs5769709 chr22:50021757 C/T cg20744362 chr22:50050164 C22orf34 0.44 7.13 0.4 9.27e-12 Monocyte count;Monocyte percentage of white cells; CESC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg13866156 chr1:1669148 SLC35E2 -0.51 -6.77 -0.38 8.38e-11 Body mass index; CESC cis rs2279817 0.954 rs12143113 chr1:18018857 T/C cg21791023 chr1:18019539 ARHGEF10L 0.57 7.84 0.43 1.14e-13 Neuroticism; CESC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg04013166 chr16:89971882 TCF25 0.69 7.12 0.4 1.04e-11 Skin colour saturation; CESC trans rs7944735 0.517 rs12274550 chr11:48196752 C/A cg15704280 chr7:45808275 SEPT13 0.7 6.76 0.38 8.86e-11 Intraocular pressure; CESC cis rs2070488 0.695 rs6599201 chr3:38476614 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 12.48 0.61 2.05e-28 Electrocardiographic conduction measures; CESC cis rs4555082 0.834 rs2816652 chr14:105712493 C/T cg27165867 chr14:105738592 BRF1 -0.49 -5.3 -0.31 2.41e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7520050 0.966 rs10890361 chr1:46346234 A/T cg03146154 chr1:46216737 IPP -0.48 -6.76 -0.38 8.95e-11 Red blood cell count;Reticulocyte count; CESC cis rs7523050 0.730 rs34254854 chr1:109419875 C/T cg08274380 chr1:109419600 GPSM2 0.92 6.41 0.37 6.62e-10 Fat distribution (HIV); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22819488 chr3:28390286 AZI2 0.56 6.12 0.35 3.39e-9 Gut microbiome composition (summer); CESC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.54 7.1 0.4 1.17e-11 Lymphocyte counts; CESC cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg16339924 chr4:17578868 LAP3 0.59 7.4 0.41 1.83e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9815354 0.767 rs75651509 chr3:41953564 A/G cg03022575 chr3:42003672 ULK4 0.68 5.94 0.34 8.93e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9486715 1.000 rs9386670 chr6:97060688 C/A cg18709589 chr6:96969512 KIAA0776 -0.46 -6.23 -0.36 1.84e-9 Headache; CESC cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs11690935 0.921 rs10200608 chr2:172597929 G/A cg13550731 chr2:172543902 DYNC1I2 -0.97 -14.91 -0.68 6.48e-37 Schizophrenia; CESC cis rs11997175 0.624 rs7464055 chr8:33679382 G/A ch.8.33884649F chr8:33765107 NA 0.58 7.4 0.41 1.85e-12 Body mass index; CESC cis rs643506 0.874 rs4936786 chr11:111727227 C/T cg17089665 chr11:111648010 NA -0.36 -5.2 -0.3 4.07e-7 Breast cancer; CESC cis rs1018836 0.923 rs13254212 chr8:91582355 T/C cg16814680 chr8:91681699 NA -0.65 -8.76 -0.47 2.41e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4604732 0.631 rs11490198 chr1:247625703 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs4664304 0.802 rs1511224 chr2:160750861 C/T cg03641300 chr2:160917029 PLA2R1 -0.42 -6.0 -0.35 6.46e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs8062405 0.754 rs151179 chr16:28487056 A/G cg05966235 chr16:28915196 ATP2A1 0.36 5.22 0.31 3.61e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs10883723 0.810 rs7072351 chr10:104265047 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -5.94 -0.34 8.94e-9 Allergic disease (asthma, hay fever or eczema); CESC cis rs12142240 0.698 rs17361812 chr1:46814008 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.89 0.44 8.17e-14 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26864130 chr11:119187858 MCAM 0.52 6.28 0.36 1.41e-9 Gut microbiome composition (summer); CESC cis rs2963826 0.589 rs298091 chr5:58996603 A/T cg07145255 chr5:59995354 DEPDC1B 0.44 5.85 0.34 1.42e-8 Obesity-related traits; CESC cis rs854765 0.587 rs4077828 chr17:17833644 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.57 8.17 0.45 1.29e-14 Total body bone mineral density; CESC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg02931644 chr1:25747376 RHCE 0.38 6.31 0.36 1.16e-9 Erythrocyte sedimentation rate; CESC cis rs644799 0.965 rs11021313 chr11:95506907 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.44 0.5 1.99e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7917772 0.636 rs4919676 chr10:104524352 C/T cg04362960 chr10:104952993 NT5C2 0.45 5.11 0.3 6.07e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6439153 1.000 rs6439153 chr3:128701130 T/C cg25356066 chr3:128598488 ACAD9 0.51 6.5 0.37 3.9e-10 Pneumococcal bacteremia; CESC cis rs854765 0.583 rs4077198 chr17:17834563 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.29 0.41 3.65e-12 Total body bone mineral density; CESC cis rs2243480 0.908 rs313822 chr7:65573939 G/A cg12463550 chr7:65579703 CRCP 0.73 5.64 0.33 4.33e-8 Diabetic kidney disease; CESC cis rs12464483 0.591 rs67686878 chr2:30895044 C/T cg07150166 chr2:30669952 LCLAT1 0.52 5.1 0.3 6.52e-7 Pre-treatment pain in head and neck squamous cell carcinoma; CESC trans rs9951602 0.512 rs9953258 chr18:76651199 A/C cg02800362 chr5:177631904 HNRNPAB 0.66 8.66 0.47 4.55e-16 Obesity-related traits; CESC cis rs911555 0.504 rs8006526 chr14:104075015 T/C cg12935359 chr14:103987150 CKB -0.5 -7.26 -0.41 4.31e-12 Intelligence (multi-trait analysis); CESC cis rs13102973 0.932 rs13149380 chr4:135866539 A/C cg14419869 chr4:135874104 NA 0.36 5.81 0.34 1.8e-8 Subjective well-being; CESC cis rs11098499 0.730 rs78971550 chr4:120281041 C/T cg09307838 chr4:120376055 NA 0.85 11.06 0.56 1.25e-23 Corneal astigmatism; CESC cis rs4253772 0.938 rs78336060 chr22:46641597 C/T cg18190219 chr22:46762943 CELSR1 -0.62 -5.89 -0.34 1.19e-8 LDL cholesterol;Cholesterol, total; CESC cis rs7582720 1.000 rs72936332 chr2:204056678 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.84 7.17 0.4 7.7e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs7727544 0.735 rs272867 chr5:131681057 G/A cg07395648 chr5:131743802 NA -0.45 -6.02 -0.35 5.83e-9 Blood metabolite levels; CESC cis rs2425143 1.000 rs7261284 chr20:34244104 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.83 -7.52 -0.42 8.7e-13 Blood protein levels; CESC cis rs523522 0.962 rs1050187 chr12:120902111 A/G cg12219531 chr12:120966889 COQ5 -0.75 -9.84 -0.52 1.11e-19 High light scatter reticulocyte count; CESC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg26314531 chr2:26401878 FAM59B -0.77 -8.56 -0.47 9.38e-16 Gut microbiome composition (summer); CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg19767339 chr1:63932041 ITGB3BP 0.39 6.1 0.35 3.77e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6545883 0.965 rs7421663 chr2:61753786 C/T cg15711740 chr2:61764176 XPO1 -0.44 -5.32 -0.31 2.25e-7 Tuberculosis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18338181 chr19:13044658 FARSA -0.46 -6.01 -0.35 6.11e-9 Asthma; CESC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg22903471 chr2:27725779 GCKR -0.5 -7.11 -0.4 1.07e-11 Total body bone mineral density; CESC cis rs7568498 0.517 rs197261 chr2:161904823 A/G cg22496339 chr2:162101262 NA -0.53 -5.51 -0.32 8.32e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs2777491 0.574 rs11858812 chr15:41731550 G/A cg02330683 chr15:41787940 ITPKA 0.42 5.12 0.3 5.92e-7 Ulcerative colitis; CESC cis rs2288073 0.965 rs72789923 chr2:24394504 A/C cg06627628 chr2:24431161 ITSN2 -0.78 -8.96 -0.48 5.79e-17 Venous thromboembolism (SNP x SNP interaction); CESC cis rs2243480 1.000 rs68189316 chr7:65409169 C/G cg18252515 chr7:66147081 NA -1.06 -9.79 -0.52 1.67e-19 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01939212 chr16:85644243 KIAA0182 0.6 6.62 0.38 2.04e-10 Gut microbiome composition (summer); CESC cis rs2635047 1.000 rs2635049 chr18:44687303 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.5 -6.91 -0.39 3.69e-11 Educational attainment; CESC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg04369109 chr6:150039330 LATS1 -0.39 -5.43 -0.32 1.28e-7 Lung cancer; CESC cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg05347473 chr6:146136440 FBXO30 -0.69 -8.86 -0.48 1.22e-16 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14922886 chr7:27239701 HOXA13 -0.39 -6.15 -0.35 2.9e-9 Gambling; CESC trans rs7618501 0.933 rs6809431 chr3:49804119 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.59 8.5 0.46 1.36e-15 Intelligence (multi-trait analysis); CESC trans rs9467711 0.790 rs13195401 chr6:26463574 G/T cg06606381 chr12:133084897 FBRSL1 -1.06 -8.04 -0.44 3.05e-14 Autism spectrum disorder or schizophrenia; CESC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg12564285 chr5:131593104 PDLIM4 -0.4 -6.19 -0.36 2.23e-9 Acylcarnitine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08950886 chr10:33247484 ITGB1 0.59 7.38 0.41 2.03e-12 Gut microbiome composition (summer); CESC cis rs9611519 0.929 rs4821991 chr22:41440683 T/C cg03806693 chr22:41940476 POLR3H -0.56 -5.88 -0.34 1.22e-8 Neuroticism; CESC cis rs3806843 0.735 rs2563333 chr5:140052271 A/G cg26395211 chr5:140044315 WDR55 0.45 6.0 0.35 6.57e-9 Depressive symptoms (multi-trait analysis); CESC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg24881330 chr22:46731750 TRMU 0.81 7.31 0.41 3.09e-12 LDL cholesterol;Cholesterol, total; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22935501 chr17:78234799 RNF213 0.53 6.24 0.36 1.76e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11886286 chr6:27114864 HIST1H2BK;HIST1H2AH -0.56 -6.12 -0.35 3.38e-9 Gut microbiome composition (summer); CESC cis rs8067545 0.611 rs2703812 chr17:20114803 A/G cg13482628 chr17:19912719 NA -0.42 -5.68 -0.33 3.46e-8 Schizophrenia; CESC cis rs4481887 0.790 rs10888364 chr1:248488387 T/G cg00666640 chr1:248458726 OR2T12 0.35 5.98 0.35 7.04e-9 Common traits (Other); CESC cis rs2742417 0.603 rs13059502 chr3:45781380 A/G cg04837898 chr3:45731254 SACM1L -0.46 -6.04 -0.35 5.31e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg12311346 chr5:56204834 C5orf35 -0.72 -8.86 -0.48 1.15e-16 Initial pursuit acceleration; CESC trans rs7584330 0.554 rs77956735 chr2:238399130 C/T cg06514003 chr17:40330907 KCNH4 -0.74 -6.2 -0.36 2.1e-9 Prostate cancer; CESC cis rs10089 0.953 rs6887674 chr5:127531183 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 9.05 0.49 3.19e-17 Ileal carcinoids; CESC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg06074448 chr4:187884817 NA -0.36 -5.06 -0.3 7.74e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg18252515 chr7:66147081 NA -0.47 -6.08 -0.35 4.25e-9 Aortic root size; CESC cis rs9486719 1.000 rs2472895 chr6:96870387 A/T cg06623918 chr6:96969491 KIAA0776 0.81 8.29 0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg05552183 chr6:42928497 GNMT 0.76 11.28 0.57 2.39e-24 Alzheimer's disease in APOE e4+ carriers; CESC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg18337363 chr3:52569053 NT5DC2 0.3 5.93 0.34 9.48e-9 Bipolar disorder; CESC cis rs4589502 1.000 rs75502100 chr15:67131417 T/C cg12317470 chr15:67143691 NA 0.72 5.87 0.34 1.31e-8 Lung cancer (smoking interaction); CESC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.4 0.57 9.22e-25 Alzheimer's disease; CESC cis rs12451471 0.667 rs12942002 chr17:78101629 C/G cg06718696 chr17:78121285 EIF4A3 0.87 10.99 0.56 2.15e-23 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs698833 0.926 rs786626 chr2:44604066 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.47 6.06 0.35 4.56e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.67 9.36 0.5 3.44e-18 Menopause (age at onset); CESC cis rs7447593 0.518 rs4074995 chr5:176797343 C/T cg17509989 chr5:176798049 RGS14 0.75 8.44 0.46 2.1e-15 Urinary electrolytes (magnesium/calcium ratio); CESC cis rs796364 0.694 rs1653299 chr2:201075611 A/G cg23649088 chr2:200775458 C2orf69 0.6 7.38 0.41 1.99e-12 Schizophrenia; CESC cis rs8050907 0.744 rs7191458 chr16:4511752 T/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.86 5.97 0.34 7.5e-9 Obesity-related traits; CESC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg07395648 chr5:131743802 NA 0.43 5.58 0.32 5.91e-8 Breast cancer; CESC cis rs6011002 0.935 rs41309933 chr20:62311377 G/A cg15212369 chr20:62274085 STMN3 -0.59 -5.11 -0.3 6.12e-7 Dental caries; CESC cis rs9790314 1.000 rs464766 chr3:161087592 C/G cg04691961 chr3:161091175 C3orf57 -0.44 -5.66 -0.33 4e-8 Morning vs. evening chronotype; CESC cis rs7312774 0.618 rs28716736 chr12:107364410 A/G cg16260113 chr12:107380972 MTERFD3 0.79 6.89 0.39 4.15e-11 Severe influenza A (H1N1) infection; CESC trans rs561341 1.000 rs508192 chr17:30315147 C/T cg27661571 chr11:113659931 NA 0.75 6.68 0.38 1.4e-10 Hip circumference adjusted for BMI; CESC cis rs870825 0.616 rs2090589 chr4:185647731 A/G cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs854765 0.619 rs4561528 chr17:17979099 C/T cg04398451 chr17:18023971 MYO15A -0.8 -12.02 -0.59 7.2e-27 Total body bone mineral density; CESC cis rs763014 0.838 rs4984670 chr16:641044 A/G cg09263875 chr16:632152 PIGQ 0.69 11.21 0.57 3.95e-24 Height; CESC cis rs4268898 0.662 rs59996104 chr2:24404064 C/T cg08917208 chr2:24149416 ATAD2B 0.6 5.56 0.32 6.71e-8 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14727059 chr3:53195316 PRKCD 0.57 6.11 0.35 3.49e-9 Gut microbiome composition (summer); CESC cis rs644799 0.965 rs573758 chr11:95539591 G/T cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg07507251 chr3:52567010 NT5DC2 0.54 11.08 0.56 1.11e-23 Electroencephalogram traits; CESC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg13866156 chr1:1669148 SLC35E2 -0.5 -6.53 -0.37 3.26e-10 Body mass index; CESC cis rs829883 0.664 rs829876 chr12:98842138 A/G cg25150519 chr12:98850993 NA 0.88 15.05 0.68 2e-37 Colorectal adenoma (advanced); CESC cis rs17376456 0.825 rs28705226 chr5:93233135 T/C cg25358565 chr5:93447407 FAM172A 1.09 10.71 0.55 1.77e-22 Diabetic retinopathy; CESC cis rs11792861 0.926 rs72607169 chr9:111832471 A/T cg05043794 chr9:111880884 C9orf5 -0.39 -6.39 -0.37 7.25e-10 Menarche (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11371681 chr1:26606896 SH3BGRL3 0.48 6.11 0.35 3.52e-9 Gut microbiota (bacterial taxa); CESC cis rs910316 0.737 rs175084 chr14:75519175 C/T cg11812906 chr14:75593930 NEK9 -0.83 -13.45 -0.64 9e-32 Height; CESC cis rs10791097 0.568 rs4411284 chr11:130738568 A/C cg12179176 chr11:130786555 SNX19 0.64 9.95 0.52 4.91e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4076764 1.000 rs7525643 chr1:163426283 G/A cg06092702 chr1:163392909 NA -0.37 -5.38 -0.31 1.63e-7 Motion sickness; CESC cis rs9902453 0.845 rs58606097 chr17:28020379 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.53 0.46 1.15e-15 Coffee consumption (cups per day); CESC trans rs12095761 0.515 rs6604648 chr1:217018694 A/G cg02004048 chr6:109868066 AKD1 -0.39 -6.07 -0.35 4.49e-9 Breast cancer; CESC cis rs2243480 1.000 rs59794892 chr7:65415873 G/A cg13147721 chr7:65941812 NA -0.83 -7.94 -0.44 5.77e-14 Diabetic kidney disease; CESC cis rs3796619 1.000 rs11939380 chr4:1086871 C/T cg27284194 chr4:1044797 NA -0.37 -5.7 -0.33 3.27e-8 Recombination rate (males); CESC cis rs10504073 0.647 rs56057508 chr8:49982793 G/T cg00325661 chr8:49890786 NA 0.53 7.77 0.43 1.76e-13 Blood metabolite ratios; CESC cis rs7520050 0.966 rs10749860 chr1:46328210 C/G cg03146154 chr1:46216737 IPP -0.49 -6.37 -0.36 8.44e-10 Red blood cell count;Reticulocyte count; CESC cis rs12586317 0.547 rs4982234 chr14:35460106 T/A cg16230307 chr14:35515116 FAM177A1 0.98 10.57 0.54 5.04e-22 Psoriasis; CESC cis rs9611565 0.513 rs739135 chr22:42090069 A/C cg06634786 chr22:41940651 POLR3H 0.65 6.47 0.37 4.73e-10 Vitiligo; CESC cis rs6430585 0.527 rs60966546 chr2:136401843 C/T cg07169764 chr2:136633963 MCM6 1.04 12.32 0.6 7.31e-28 Corneal structure; CESC cis rs1983170 0.935 rs578155 chr1:91976541 G/A cg02896835 chr1:92012615 NA -0.53 -5.91 -0.34 1.07e-8 Eosinophil percentage of white cells; CESC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg16049864 chr8:95962084 TP53INP1 -0.65 -11.4 -0.57 9.17e-25 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00028918 chr5:159200479 NA -0.6 -6.35 -0.36 9.54e-10 Gut microbiome composition (summer); CESC cis rs2072732 0.861 rs10909866 chr1:2960372 C/T cg03976712 chr1:2946727 NA 0.35 5.63 0.33 4.52e-8 Plateletcrit; CESC trans rs7246657 0.943 rs2112923 chr19:37940327 C/T cg24637308 chr11:6592297 DNHD1 0.54 6.34 0.36 1.01e-9 Coronary artery calcification; CESC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg21782813 chr7:2030301 MAD1L1 0.41 5.86 0.34 1.37e-8 Bipolar disorder and schizophrenia; CESC cis rs7635838 0.859 rs9869423 chr3:11459156 G/T cg00170343 chr3:11313890 ATG7 0.43 5.73 0.33 2.76e-8 HDL cholesterol; CESC cis rs7615952 0.800 rs13086460 chr3:125646417 C/T cg05084668 chr3:125655381 ALG1L -0.51 -5.95 -0.34 8.56e-9 Blood pressure (smoking interaction); CESC cis rs2882667 0.858 rs6882112 chr5:138413735 C/T cg04439458 chr5:138467593 SIL1 0.37 6.1 0.35 3.78e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs17253792 0.598 rs71413578 chr14:56018651 T/C cg01858014 chr14:56050164 KTN1 -0.89 -6.36 -0.36 9.03e-10 Putamen volume; CESC cis rs3011225 0.683 rs4660753 chr1:44321044 G/A cg12908607 chr1:44402522 ARTN -0.46 -6.6 -0.38 2.26e-10 Amyotrophic lateral sclerosis (age of onset); CESC trans rs7906315 0.967 rs3814573 chr10:114898093 C/T cg20053493 chr11:47776175 FNBP4 -0.44 -6.41 -0.37 6.52e-10 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11344626 chr1:14026360 PRDM2 -0.51 -6.1 -0.35 3.65e-9 Gut microbiome composition (summer); CESC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg18099408 chr3:52552593 STAB1 -0.36 -6.09 -0.35 4.06e-9 Electroencephalogram traits; CESC cis rs72781680 0.566 rs72794293 chr2:23898149 A/G cg08917208 chr2:24149416 ATAD2B 0.7 6.84 0.39 5.48e-11 Lymphocyte counts; CESC cis rs2268241 0.938 rs9978166 chr21:34770516 A/G cg14850771 chr21:34775459 IFNGR2 0.89 10.99 0.56 2.19e-23 Obesity-related traits; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg04127825 chr1:167503222 NA 0.45 6.01 0.35 6.15e-9 Systemic lupus erythematosus; CESC cis rs7259376 0.936 rs8108630 chr19:22535177 G/T cg02657401 chr19:22469223 NA -0.27 -5.31 -0.31 2.28e-7 Menopause (age at onset); CESC cis rs10504229 0.593 rs11781042 chr8:57993056 A/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.06 -0.4 1.45e-11 Developmental language disorder (linguistic errors); CESC cis rs2204008 0.540 rs1672425 chr12:38122842 G/A cg26384229 chr12:38710491 ALG10B -0.46 -6.46 -0.37 4.93e-10 Bladder cancer; CESC cis rs17253792 0.822 rs10147688 chr14:56054642 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.99 0.35 6.73e-9 Putamen volume; CESC cis rs300703 1.000 rs300703 chr2:239416 C/T cg21211680 chr2:198530 NA 0.96 7.57 0.42 6.12e-13 Blood protein levels; CESC cis rs4730250 0.634 rs257371 chr7:106795043 C/A cg02696742 chr7:106810147 HBP1 -0.55 -5.18 -0.3 4.44e-7 Osteoarthritis; CESC cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.9 -11.57 -0.58 2.47e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7599312 0.534 rs7355673 chr2:213404389 T/C cg20637307 chr2:213403960 ERBB4 0.57 8.92 0.48 7.78e-17 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4319547 0.956 rs10773302 chr12:123043145 G/T cg05707623 chr12:122985044 ZCCHC8 -0.56 -6.69 -0.38 1.3e-10 Body mass index; CESC cis rs6540556 0.637 rs12060922 chr1:209904433 G/A cg05527609 chr1:210001259 C1orf107 -0.68 -7.5 -0.42 9.46e-13 Red blood cell count; CESC cis rs6582630 0.519 rs12578283 chr12:38325349 A/T cg26384229 chr12:38710491 ALG10B 0.72 10.83 0.55 7.25e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.77 -10.39 -0.54 1.97e-21 Mean platelet volume; CESC cis rs35849525 0.776 rs7615318 chr3:49987475 C/T cg24110177 chr3:50126178 RBM5 -0.43 -5.1 -0.3 6.39e-7 Intelligence (multi-trait analysis); CESC cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg03467027 chr4:99064603 C4orf37 0.42 5.29 0.31 2.5e-7 Colonoscopy-negative controls vs population controls; CESC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg23281280 chr6:28129359 ZNF389 0.56 7.62 0.42 4.55e-13 Depression; CESC cis rs826838 1.000 rs11168217 chr12:38884278 T/C cg26384229 chr12:38710491 ALG10B 0.83 14.68 0.67 4e-36 Heart rate; CESC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg27535305 chr1:53392650 SCP2 0.34 6.03 0.35 5.37e-9 Monocyte count; CESC cis rs6964587 0.967 rs7786031 chr7:91649001 T/G cg17063962 chr7:91808500 NA 0.57 7.86 0.43 9.58e-14 Breast cancer; CESC cis rs1801251 1.000 rs991873 chr2:233711046 A/G cg25237894 chr2:233734115 C2orf82 -0.47 -8.28 -0.45 6.12e-15 Coronary artery disease; CESC cis rs10979 1.000 rs9496678 chr6:143896664 C/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.13e-17 Hypospadias; CESC cis rs6772849 0.930 rs55987729 chr3:128340110 T/C cg16766828 chr3:128327626 NA -0.31 -5.13 -0.3 5.62e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg18876405 chr7:65276391 NA 0.51 6.92 0.39 3.39e-11 Aortic root size; CESC cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1514687 0.534 rs2138020 chr2:1482093 T/A cg13703866 chr2:1479523 TPO -0.79 -6.17 -0.35 2.53e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg04025307 chr7:1156635 C7orf50 0.49 6.73 0.38 1.02e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -7.36 -0.41 2.31e-12 Neuroticism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg18548362 chr4:1857197 LETM1 0.45 6.36 0.36 8.68e-10 Gut microbiota (bacterial taxa); CESC cis rs763121 0.853 rs2076028 chr22:39150450 G/A cg21395723 chr22:39101663 GTPBP1 0.45 5.75 0.33 2.41e-8 Menopause (age at onset); CESC cis rs9325144 0.513 rs12313652 chr12:38665412 G/A cg26384229 chr12:38710491 ALG10B -0.6 -8.49 -0.46 1.45e-15 Morning vs. evening chronotype; CESC cis rs2882667 0.858 rs11959803 chr5:138451315 G/A cg04439458 chr5:138467593 SIL1 -0.39 -6.02 -0.35 5.74e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg01411255 chr17:61851458 DDX42;CCDC47 1.1 19.13 0.76 7.67e-52 Height; CESC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg09177884 chr7:1199841 ZFAND2A 0.4 5.03 0.3 8.88e-7 Longevity;Endometriosis; CESC cis rs7129220 0.588 rs61878628 chr11:10128872 T/G cg01453529 chr11:10209919 SBF2 -0.48 -5.5 -0.32 8.85e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs4604732 0.631 rs12038880 chr1:247624603 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.56 7.5 0.42 9.89e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs72627123 0.582 rs62005102 chr14:74500586 T/A cg05179529 chr14:74551516 LIN52;ALDH6A1 0.56 5.57 0.32 6.34e-8 Morning vs. evening chronotype; CESC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.72 9.91 0.52 6.86e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9815354 0.812 rs59146151 chr3:41949301 T/C cg03022575 chr3:42003672 ULK4 0.71 6.45 0.37 5.42e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs863345 0.967 rs11264998 chr1:158488766 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -5.97 -0.34 7.49e-9 Pneumococcal bacteremia; CESC cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg03060546 chr3:49711283 APEH 0.45 5.5 0.32 9e-8 Parkinson's disease; CESC cis rs10931896 0.531 rs296801 chr2:201142812 C/T cg23649088 chr2:200775458 C2orf69 0.55 7.72 0.43 2.42e-13 Systolic blood pressure; CESC cis rs7589728 0.858 rs79992736 chr2:88530575 A/C cg14558114 chr2:88469736 THNSL2 0.54 6.06 0.35 4.64e-9 Plasma clusterin levels; CESC cis rs2637266 0.538 rs11001852 chr10:78445987 G/C cg18941641 chr10:78392320 NA -0.33 -5.22 -0.31 3.63e-7 Pulmonary function; CESC cis rs3820068 0.608 rs12740492 chr1:16048951 A/T cg17385448 chr1:15911702 AGMAT 0.37 5.67 0.33 3.82e-8 Systolic blood pressure; CESC cis rs35110281 0.782 rs2051407 chr21:45079245 T/C cg04455712 chr21:45112962 RRP1B 0.4 5.96 0.34 7.97e-9 Mean corpuscular volume; CESC cis rs72781680 1.000 rs72796359 chr2:24160545 T/C cg08917208 chr2:24149416 ATAD2B 1.12 10.07 0.53 2.16e-20 Lymphocyte counts; CESC cis rs9858542 0.953 rs6997 chr3:49453834 C/T cg07274523 chr3:49395745 GPX1 0.65 8.57 0.47 8.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs367943 0.901 rs463167 chr5:112799369 C/A cg12552261 chr5:112820674 MCC -0.62 -7.85 -0.43 1.05e-13 Type 2 diabetes; CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg14159672 chr1:205819179 PM20D1 0.9 15.91 0.7 1.82e-40 Menarche (age at onset); CESC cis rs3026101 0.624 rs1806261 chr17:5317008 A/C cg25236894 chr17:5323110 RPAIN;NUP88 0.46 5.97 0.34 7.7e-9 Body mass index; CESC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg08822215 chr16:89438651 ANKRD11 -0.34 -5.13 -0.3 5.54e-7 Multiple myeloma (IgH translocation); CESC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg12667521 chr19:29218732 NA 0.48 6.75 0.38 9.2e-11 Methadone dose in opioid dependence; CESC cis rs1707322 1.000 rs785497 chr1:46591903 G/C cg03146154 chr1:46216737 IPP -0.74 -9.64 -0.51 4.75e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1062177 1.000 rs1062177 chr5:151184701 C/T cg00977110 chr5:151150581 G3BP1 0.63 6.88 0.39 4.37e-11 Preschool internalizing problems; CESC cis rs7605827 0.930 rs10929365 chr2:15531626 G/A cg19274914 chr2:15703543 NA 0.35 6.2 0.36 2.14e-9 Educational attainment (years of education); CESC cis rs9308433 0.529 rs55760458 chr1:214491536 G/C cg06198575 chr1:214491504 SMYD2 0.5 6.02 0.35 5.67e-9 IgG glycosylation; CESC cis rs13242816 1.000 rs6968230 chr7:116137049 G/T cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC cis rs68170813 0.599 rs77878465 chr7:106890996 G/A cg02696742 chr7:106810147 HBP1 -0.52 -5.14 -0.3 5.32e-7 Coronary artery disease; CESC cis rs3091242 0.933 rs11249250 chr1:25767609 G/A cg12412775 chr1:25698385 RHCE -0.29 -5.17 -0.3 4.61e-7 Erythrocyte sedimentation rate; CESC cis rs9894429 1.000 rs9748176 chr17:79584043 C/G cg18240062 chr17:79603768 NPLOC4 0.72 10.24 0.53 5.94e-21 Eye color traits; CESC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg07701084 chr6:150067640 NUP43 0.41 5.5 0.32 8.83e-8 Lung cancer; CESC cis rs7220401 0.512 rs71371126 chr17:28002642 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.64 -6.64 -0.38 1.78e-10 Coronary artery disease; CESC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg08061076 chr7:1943177 MAD1L1 -0.38 -5.07 -0.3 7.38e-7 Bipolar disorder and schizophrenia; CESC cis rs12410462 0.581 rs77837509 chr1:227559873 C/T cg04117972 chr1:227635322 NA 0.69 5.84 0.34 1.54e-8 Major depressive disorder; CESC trans rs9929218 0.954 rs112225541 chr16:68755165 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -9.77 -0.51 1.8e-19 Colorectal cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg08977639 chr16:1047820 NA 0.44 6.16 0.35 2.67e-9 Systemic lupus erythematosus; CESC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 12.74 0.62 2.47e-29 Platelet count; CESC cis rs9649465 0.967 rs12537989 chr7:123308195 A/G cg04330084 chr7:123175371 IQUB -0.37 -5.05 -0.3 8.09e-7 Migraine; CESC cis rs9623117 0.874 rs7284980 chr22:40474513 C/T cg05033341 chr22:40419857 FAM83F -0.46 -5.2 -0.3 4.05e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs1707322 1.000 rs12077974 chr1:46384141 G/A cg05343316 chr1:45956843 TESK2 0.44 5.33 0.31 2.14e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9682041 0.696 rs11709437 chr3:170085568 T/G cg11886554 chr3:170076028 SKIL 0.7 6.49 0.37 4.1e-10 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03565437 chr5:14488482 TRIO 0.57 7.87 0.44 9.19e-14 Fibrinogen levels; CESC cis rs9611565 0.729 rs505533 chr22:41864216 A/C cg03806693 chr22:41940476 POLR3H 0.77 10.01 0.52 3.34e-20 Vitiligo; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13958304 chr1:114354463 RSBN1 -0.58 -6.12 -0.35 3.42e-9 Gut microbiome composition (summer); CESC cis rs1051424 0.642 rs115869798 chr17:57892829 T/A cg13753209 chr17:57696993 CLTC 0.67 8.48 0.46 1.6e-15 Obesity-related traits; CESC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg02269571 chr22:50332266 NA -0.45 -6.01 -0.35 6.23e-9 Schizophrenia; CESC cis rs6963495 0.818 rs73192113 chr7:105169603 C/T cg13798780 chr7:105162888 PUS7 0.77 7.88 0.44 8.3e-14 Bipolar disorder (body mass index interaction); CESC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.84 0.59 2.99e-26 Alzheimer's disease; CESC cis rs752010 0.631 rs4660549 chr1:42088102 A/G cg06885757 chr1:42089581 HIVEP3 0.7 11.13 0.56 7.59e-24 Lupus nephritis in systemic lupus erythematosus; CESC cis rs7666738 0.791 rs34152299 chr4:98929862 G/C cg17366294 chr4:99064904 C4orf37 0.6 8.22 0.45 9.04e-15 Colonoscopy-negative controls vs population controls; CESC trans rs7980799 0.649 rs1994135 chr12:33682405 T/C cg26384229 chr12:38710491 ALG10B 0.47 6.55 0.37 3.03e-10 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs12325245 0.536 rs3169293 chr16:58552959 A/G cg02549819 chr16:58548995 SETD6 0.98 6.55 0.37 3.06e-10 Schizophrenia; CESC cis rs2742234 0.503 rs1254968 chr10:43691691 C/T cg07801480 chr10:43725741 RASGEF1A -0.41 -5.31 -0.31 2.3e-7 Hirschsprung disease; CESC cis rs1784581 0.507 rs1790020 chr6:162366266 C/T cg17173639 chr6:162384350 PARK2 -0.6 -8.87 -0.48 1.14e-16 Itch intensity from mosquito bite; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23397427 chr15:51571820 CYP19A1 -0.5 -6.27 -0.36 1.49e-9 Gut microbiome composition (summer); CESC cis rs2011503 0.941 rs56135441 chr19:19371370 A/T cg20644253 chr19:19431407 KIAA0892;SF4 0.52 5.34 0.31 2.03e-7 Bipolar disorder; CESC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.08 0.4 1.27e-11 Bipolar disorder; CESC cis rs4727027 0.727 rs1568944 chr7:148873497 A/T cg23583168 chr7:148888333 NA -0.75 -9.76 -0.51 1.99e-19 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7116495 0.609 rs60054591 chr11:71825687 G/A cg10381502 chr11:71823885 C11orf51 1.06 6.8 0.39 6.99e-11 Severe influenza A (H1N1) infection; CESC trans rs1285495 0.627 rs10912059 chr1:187354887 C/T cg07564188 chr1:165667906 ALDH9A1 -0.46 -6.04 -0.35 5.27e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CESC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg02071572 chr4:1403502 NA 0.34 5.05 0.3 8.37e-7 Longevity; CESC cis rs9796 0.621 rs690733 chr15:41476465 G/A cg12386646 chr15:41787261 ITPKA 0.33 5.12 0.3 5.98e-7 Menopause (age at onset); CESC cis rs7267979 0.932 rs372678 chr20:25465248 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.73 13.31 0.63 2.6e-31 Liver enzyme levels (alkaline phosphatase); CESC cis rs6456156 0.586 rs12528323 chr6:167461645 A/G cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.2e-10 Primary biliary cholangitis; CESC cis rs12042052 0.793 rs12036759 chr1:232925441 A/G cg00951395 chr1:232941775 KIAA1383 0.83 7.02 0.4 1.82e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs2732480 0.577 rs2732466 chr12:48732459 A/G cg24011408 chr12:48396354 COL2A1 0.43 5.78 0.33 2.05e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs10779751 0.708 rs2746640 chr1:11292952 T/A cg08854313 chr1:11322531 MTOR 0.8 10.67 0.55 2.34e-22 Body mass index; CESC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg06028605 chr16:24865363 SLC5A11 0.57 8.09 0.45 2.17e-14 Intelligence (multi-trait analysis); CESC cis rs6912958 0.935 rs6454629 chr6:88165515 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -5.42 -0.32 1.32e-7 Monocyte percentage of white cells; CESC trans rs28551159 1 rs28551159 chr6:26376368 A/G cg06606381 chr12:133084897 FBRSL1 -0.76 -6.68 -0.38 1.4e-10 Urinary tract infection frequency; CESC cis rs11792861 0.781 rs72607158 chr9:111763010 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 6.58 0.37 2.54e-10 Menarche (age at onset); CESC cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg00255919 chr5:131827918 IRF1 -0.6 -10.57 -0.54 5.26e-22 Asthma (sex interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24108215 chr1:39174820 NA -0.58 -7.26 -0.41 4.2e-12 Gut microbiome composition (summer); CESC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg19901468 chr14:105411992 AHNAK2 -0.6 -8.69 -0.47 3.79e-16 Rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25329269 chr9:86432854 GKAP1 -0.59 -7.03 -0.4 1.77e-11 Gut microbiome composition (summer); CESC trans rs61931739 0.853 rs10844751 chr12:34099651 T/G cg26384229 chr12:38710491 ALG10B -0.48 -6.62 -0.38 1.95e-10 Morning vs. evening chronotype; CESC cis rs10191773 0.535 rs11685514 chr2:113100014 C/T cg07905836 chr2:113190072 RGPD8;RGPD5 0.6 5.12 0.3 5.88e-7 Yeast infection; CESC cis rs3820928 1.000 rs7592387 chr2:227777095 A/G cg11843606 chr2:227700838 RHBDD1 -0.43 -5.81 -0.34 1.74e-8 Pulmonary function; CESC cis rs9388451 0.839 rs3799711 chr6:126075313 C/T cg10911889 chr6:126070802 HEY2 -0.38 -5.23 -0.31 3.41e-7 Brugada syndrome; CESC cis rs6681460 1.000 rs2872078 chr1:67127367 C/A cg02459107 chr1:67143332 SGIP1 0.39 5.41 0.32 1.43e-7 Presence of antiphospholipid antibodies; CESC cis rs2415984 0.622 rs2415998 chr14:46930712 A/G cg14871534 chr14:47121158 RPL10L -0.34 -5.13 -0.3 5.71e-7 Number of children ever born; CESC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.34 0.41 2.6e-12 Bipolar disorder; CESC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.43 0.57 7.53e-25 Platelet count; CESC cis rs4654899 0.931 rs10799679 chr1:21341776 A/G cg05370193 chr1:21551575 ECE1 0.38 5.66 0.33 3.96e-8 Superior frontal gyrus grey matter volume; CESC cis rs4835473 0.897 rs35556180 chr4:144658748 G/A cg25736465 chr4:144833511 NA -0.34 -5.3 -0.31 2.46e-7 Immature fraction of reticulocytes; CESC cis rs561341 1.000 rs535151 chr17:30317405 C/T cg00745463 chr17:30367425 LRRC37B -0.48 -5.23 -0.31 3.42e-7 Hip circumference adjusted for BMI; CESC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg11644478 chr21:40555479 PSMG1 1.04 16.67 0.72 3.61e-43 Cognitive function; CESC cis rs4253772 0.513 rs6008612 chr22:46707907 G/A cg18190219 chr22:46762943 CELSR1 -0.44 -5.49 -0.32 9.55e-8 LDL cholesterol;Cholesterol, total; CESC cis rs17666538 0.585 rs6559063 chr8:623051 C/T cg07234876 chr8:600039 NA 0.86 5.81 0.34 1.79e-8 IgG glycosylation; CESC cis rs9611565 0.729 rs169362 chr22:41827589 G/C cg03806693 chr22:41940476 POLR3H 0.77 9.78 0.51 1.74e-19 Vitiligo; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10236037 chr2:9347576 ASAP2 -0.44 -6.52 -0.37 3.56e-10 Gambling; CESC cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg23711669 chr6:146136114 FBXO30 -1.01 -15.7 -0.69 1.03e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs4268898 0.552 rs11125454 chr2:24373669 T/C cg20701182 chr2:24300061 SF3B14 -0.38 -5.28 -0.31 2.72e-7 Asthma; CESC cis rs11997175 0.967 rs11993169 chr8:33738004 G/T ch.8.33884649F chr8:33765107 NA 0.66 8.42 0.46 2.34e-15 Body mass index; CESC cis rs4654899 0.931 rs58762579 chr1:21257831 G/A cg05370193 chr1:21551575 ECE1 0.36 5.3 0.31 2.43e-7 Superior frontal gyrus grey matter volume; CESC cis rs61996546 0.622 rs12901009 chr15:26855181 C/G cg15066197 chr15:26874202 GABRB3 -0.35 -5.19 -0.3 4.1e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs2635047 0.967 rs2684843 chr18:44726260 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 6.65 0.38 1.66e-10 Educational attainment; CESC cis rs17376456 0.825 rs17314797 chr5:93234845 T/A cg21475434 chr5:93447410 FAM172A 0.77 6.77 0.38 8.36e-11 Diabetic retinopathy; CESC cis rs4523957 0.928 rs216179 chr17:2168878 T/A cg16513277 chr17:2031491 SMG6 0.59 8.06 0.44 2.6e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9905704 0.633 rs2526369 chr17:56469113 T/C cg12560992 chr17:57184187 TRIM37 -0.61 -5.75 -0.33 2.49e-8 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10293422 chr8:17434503 PDGFRL -0.57 -6.55 -0.37 2.99e-10 Gut microbiome composition (summer); CESC cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg00033643 chr7:134001901 SLC35B4 0.44 5.71 0.33 3.05e-8 Mean platelet volume; CESC cis rs12313068 0.709 rs11064912 chr12:110505699 A/T cg12870014 chr12:110450643 ANKRD13A -0.8 -9.45 -0.5 1.91e-18 Intelligence (multi-trait analysis); CESC cis rs12500824 0.564 rs7660503 chr4:77319044 A/G cg20311846 chr4:77356250 SHROOM3 0.39 7.5 0.42 9.73e-13 Coronary artery disease; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg14544983 chr19:47248940 FKRP;STRN4 -0.43 -6.06 -0.35 4.67e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2274273 1.000 rs1047556 chr14:55600282 A/T cg04306507 chr14:55594613 LGALS3 0.28 5.28 0.31 2.63e-7 Protein biomarker; CESC cis rs3820928 0.605 rs4281898 chr2:227855493 A/C cg05526886 chr2:227700861 RHBDD1 -0.48 -6.43 -0.37 5.76e-10 Pulmonary function; CESC cis rs67478160 0.643 rs3742369 chr14:104251276 T/C cg08213375 chr14:104286397 PPP1R13B 0.55 10.97 0.56 2.52e-23 Schizophrenia; CESC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.77 11.06 0.56 1.26e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs561341 1.000 rs483301 chr17:30293398 G/T cg23018236 chr17:30244563 NA -0.55 -5.31 -0.31 2.37e-7 Hip circumference adjusted for BMI; CESC cis rs3015497 0.527 rs2934670 chr14:51153409 G/A cg26011998 chr14:51135199 SAV1 -0.57 -6.36 -0.36 8.78e-10 Mean platelet volume; CESC cis rs7809950 0.954 rs2189839 chr7:107230026 A/G cg23024343 chr7:107201750 COG5 0.41 5.68 0.33 3.5e-8 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12568633 chr10:73533407 CDH23;C10orf54 0.64 7.8 0.43 1.42e-13 Gut microbiome composition (summer); CESC cis rs7193541 0.673 rs12716769 chr16:74652537 T/C cg01733217 chr16:74700730 RFWD3 1.06 20.52 0.78 1.11e-56 Multiple myeloma; CESC cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg05890377 chr2:74357713 NA 0.77 10.48 0.54 9.95e-22 Gestational age at birth (maternal effect); CESC cis rs4979906 0.920 rs11002239 chr10:79443836 A/C cg00983440 chr10:79422392 NA -0.48 -5.1 -0.3 6.57e-7 Mortality in heart failure; CESC cis rs863345 0.526 rs857724 chr1:158607372 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.51 -0.32 8.53e-8 Pneumococcal bacteremia; CESC cis rs9393777 0.920 rs34150729 chr6:27388754 T/C cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 5.46 0.32 1.08e-7 Intelligence (multi-trait analysis); CESC cis rs826838 0.967 rs11169169 chr12:39093153 A/C cg13010199 chr12:38710504 ALG10B 0.57 7.95 0.44 5.42e-14 Heart rate; CESC cis rs10463316 0.894 rs7719630 chr5:150760961 C/T cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg06481639 chr22:41940642 POLR3H -0.62 -6.61 -0.38 2.12e-10 Vitiligo; CESC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg17372223 chr3:52568218 NT5DC2 0.42 6.35 0.36 9.4e-10 Bipolar disorder; CESC cis rs9790314 0.586 rs11710916 chr3:161130070 A/G cg03342759 chr3:160939853 NMD3 -0.42 -5.86 -0.34 1.34e-8 Morning vs. evening chronotype; CESC cis rs9611565 0.879 rs2235845 chr22:41729294 T/G cg06481639 chr22:41940642 POLR3H -0.46 -5.29 -0.31 2.55e-7 Vitiligo; CESC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs909341 0.629 rs3761124 chr20:62288752 T/C cg03999872 chr20:62272968 STMN3 0.56 5.43 0.32 1.27e-7 Atopic dermatitis; CESC cis rs11048434 0.761 rs12827055 chr12:9130861 G/T cg23795048 chr12:9217529 LOC144571 0.34 5.05 0.3 8.31e-7 Sjögren's syndrome; CESC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg16405210 chr4:1374714 KIAA1530 -0.48 -6.11 -0.35 3.56e-9 Obesity-related traits; CESC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg05564831 chr3:52568323 NT5DC2 0.42 6.19 0.36 2.26e-9 Bipolar disorder; CESC cis rs12620999 0.941 rs7593758 chr2:237980920 G/T cg23555395 chr2:238036564 NA -0.42 -6.05 -0.35 4.97e-9 Systemic lupus erythematosus; CESC trans rs11098499 0.754 rs9991959 chr4:120253773 C/T cg25214090 chr10:38739885 LOC399744 -0.62 -8.81 -0.48 1.73e-16 Corneal astigmatism; CESC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 11.76 0.59 5.69e-26 Platelet count; CESC cis rs757110 0.745 rs2074311 chr11:17421860 A/G cg15432903 chr11:17409602 KCNJ11 0.55 7.55 0.42 7.22e-13 Type 2 diabetes; CESC cis rs265548 0.538 rs36688 chr19:17911212 A/C cg16744531 chr19:17905626 B3GNT3 0.6 8.23 0.45 8.48e-15 Tumor biomarkers; CESC trans rs11098499 0.954 rs6849171 chr4:120409549 G/A cg25214090 chr10:38739885 LOC399744 0.71 10.21 0.53 7.28e-21 Corneal astigmatism; CESC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.67 9.73 0.51 2.43e-19 Prudent dietary pattern; CESC cis rs7818688 0.697 rs58282276 chr8:95985391 G/A cg16049864 chr8:95962084 TP53INP1 0.57 5.73 0.33 2.68e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09122683 chr20:56285701 PMEPA1 -0.48 -6.27 -0.36 1.46e-9 Asthma; CESC cis rs10504073 0.647 rs9643394 chr8:50014427 A/G cg00325661 chr8:49890786 NA 0.52 7.93 0.44 6.02e-14 Blood metabolite ratios; CESC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.41 -0.32 1.41e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.23e-15 Colonoscopy-negative controls vs population controls; CESC cis rs977987 0.843 rs11649638 chr16:75488285 G/A cg03315344 chr16:75512273 CHST6 0.44 6.44 0.37 5.73e-10 Dupuytren's disease; CESC cis rs4803468 1.000 rs10422956 chr19:41901261 C/T cg08477640 chr19:41863820 B9D2 0.38 5.05 0.3 8.16e-7 Height; CESC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Tonsillectomy; CESC cis rs6445967 1.000 rs14927 chr3:58305033 G/T cg23715586 chr3:58305044 RPP14 -0.43 -7.1 -0.4 1.15e-11 Platelet count; CESC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg06873352 chr17:61820015 STRADA 0.7 12.33 0.6 6.27e-28 Prudent dietary pattern; CESC cis rs9916302 0.706 rs12947506 chr17:37707592 A/G cg20243544 chr17:37824526 PNMT 0.5 5.07 0.3 7.55e-7 Glomerular filtration rate (creatinine); CESC cis rs9355610 0.609 rs9366076 chr6:167373708 C/T cg23791538 chr6:167370224 RNASET2 0.49 5.81 0.34 1.75e-8 Graves' disease; CESC cis rs10870270 1.000 rs10870292 chr10:133770782 G/C cg17892150 chr10:133769511 PPP2R2D -0.85 -12.49 -0.61 1.79e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg19346786 chr7:2764209 NA -0.52 -7.38 -0.41 1.99e-12 Height; CESC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg03188948 chr7:1209495 NA 0.7 6.71 0.38 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6541297 0.775 rs4846910 chr1:230291441 C/A cg20703242 chr1:230279135 GALNT2 0.68 9.26 0.49 6.99e-18 Coronary artery disease; CESC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg23978390 chr7:1156363 C7orf50 0.65 6.41 0.37 6.82e-10 Bronchopulmonary dysplasia; CESC cis rs2836950 0.501 rs2070865 chr21:40715519 C/T cg11890956 chr21:40555474 PSMG1 -0.59 -7.69 -0.43 2.98e-13 Menarche (age at onset); CESC cis rs9361491 0.657 rs9352625 chr6:79454754 G/A cg05283184 chr6:79620031 NA -0.34 -5.04 -0.3 8.67e-7 Intelligence (multi-trait analysis); CESC cis rs1348850 0.645 rs10181259 chr2:178428256 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 5.83 0.34 1.58e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs854765 0.583 rs5002487 chr17:17832460 A/G cg16928487 chr17:17741425 SREBF1 -0.58 -10.17 -0.53 1e-20 Total body bone mineral density; CESC cis rs34779708 0.931 rs2384275 chr10:35297142 A/G cg04310649 chr10:35416472 CREM -0.52 -6.34 -0.36 9.99e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs35362007 0.530 rs10484053 chr14:96011645 C/T cg13511115 chr14:96000878 GLRX5;SNHG10;SCARNA13 0.66 5.36 0.31 1.81e-7 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs6088580 0.634 rs6058052 chr20:33047084 A/G cg24642439 chr20:33292090 TP53INP2 0.52 6.87 0.39 4.68e-11 Glomerular filtration rate (creatinine); CESC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg24818145 chr4:99064322 C4orf37 0.39 5.09 0.3 6.95e-7 Colonoscopy-negative controls vs population controls; CESC cis rs617219 0.889 rs1533760 chr5:78438937 A/C cg22188827 chr5:78429774 NA -0.43 -5.1 -0.3 6.62e-7 Betaine levels in individuals undergoing cardiac evaluation; CESC cis rs807669 0.903 rs2854643 chr22:19189706 T/C cg02655711 chr22:19163373 SLC25A1 0.95 14.13 0.66 3.59e-34 Metabolite levels; CESC cis rs763121 0.889 rs6001209 chr22:39121252 C/T cg06544989 chr22:39130855 UNC84B -0.46 -7.75 -0.43 1.98e-13 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07150772 chr14:90864620 CALM1 -0.58 -6.64 -0.38 1.72e-10 Gut microbiome composition (summer); CESC cis rs9457247 1.000 rs4710147 chr6:167374239 G/A cg25258033 chr6:167368657 RNASET2 -0.42 -6.29 -0.36 1.31e-9 Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02164407 chr11:8008755 EIF3F -0.56 -6.16 -0.35 2.62e-9 Gut microbiome composition (summer); CESC cis rs561341 0.769 rs12941700 chr17:30185022 A/G cg00745463 chr17:30367425 LRRC37B 0.59 5.62 0.33 4.73e-8 Hip circumference adjusted for BMI; CESC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg10074409 chr1:209979377 IRF6 0.4 5.32 0.31 2.16e-7 Cleft lip with or without cleft palate; CESC cis rs10979 0.965 rs9376758 chr6:143886878 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.08e-17 Hypospadias; CESC cis rs3733418 0.799 rs13151735 chr4:165932516 G/C cg10852876 chr4:165953100 TRIM60 -0.48 -5.72 -0.33 2.88e-8 Obesity-related traits; CESC cis rs763121 0.706 rs3827356 chr22:39064806 G/T cg14440974 chr22:39074834 NA 0.35 5.06 0.3 7.98e-7 Menopause (age at onset); CESC cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg22875332 chr1:76189707 ACADM 0.71 9.78 0.51 1.76e-19 Blood metabolite levels;Acylcarnitine levels; CESC trans rs2727020 0.521 rs10839299 chr11:49573981 C/T cg03929089 chr4:120376271 NA -0.71 -8.18 -0.45 1.21e-14 Coronary artery disease; CESC cis rs9790314 1.000 rs1600209 chr3:161038217 A/T cg03342759 chr3:160939853 NMD3 -0.48 -6.25 -0.36 1.61e-9 Morning vs. evening chronotype; CESC cis rs8180040 0.932 rs1038394 chr3:47464122 A/G cg27129171 chr3:47204927 SETD2 0.64 9.68 0.51 3.54e-19 Colorectal cancer; CESC cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg18512352 chr11:47633146 NA -0.5 -7.08 -0.4 1.31e-11 Subjective well-being; CESC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg08470875 chr2:26401718 FAM59B -0.7 -7.42 -0.41 1.55e-12 Gut microbiome composition (summer); CESC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg12463550 chr7:65579703 CRCP 0.49 6.29 0.36 1.29e-9 Aortic root size; CESC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg04282206 chr17:62833786 PLEKHM1P 0.57 6.54 0.37 3.22e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg05564831 chr3:52568323 NT5DC2 0.46 7.21 0.41 5.71e-12 Electroencephalogram traits; CESC cis rs3136441 1.000 rs2290883 chr11:46890197 A/G cg25783544 chr11:47291846 MADD -0.55 -5.3 -0.31 2.45e-7 HDL cholesterol; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg01989157 chr22:40742702 ADSL -0.4 -6.04 -0.35 5.22e-9 Vertical cup-disc ratio; CESC cis rs701145 0.556 rs355779 chr3:153977253 T/C cg16511985 chr3:153974050 SGEF 0.44 5.9 0.34 1.1e-8 Coronary artery disease; CESC cis rs4950322 0.570 rs72691102 chr1:146772888 A/T cg22381352 chr1:146742008 CHD1L -0.46 -5.05 -0.3 8.32e-7 Protein quantitative trait loci; CESC cis rs7000551 0.715 rs2461477 chr8:22378314 A/G cg12081754 chr8:22256438 SLC39A14 0.42 5.61 0.33 5.13e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs367943 0.712 rs13188946 chr5:112722855 C/T cg12552261 chr5:112820674 MCC 0.39 5.24 0.31 3.25e-7 Type 2 diabetes; CESC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg22920501 chr2:26401640 FAM59B -0.69 -8.4 -0.46 2.74e-15 Gut microbiome composition (summer); CESC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg06634786 chr22:41940651 POLR3H -0.63 -6.61 -0.38 2.1e-10 Vitiligo; CESC cis rs208520 0.690 rs6932475 chr6:66863155 G/A cg07460842 chr6:66804631 NA -1.0 -13.46 -0.64 8.08e-32 Exhaled nitric oxide output; CESC cis rs1348850 0.793 rs6736390 chr2:178480314 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 7.37 0.41 2.17e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04391736 chr16:69373674 COG8;NIP7 -0.61 -7.3 -0.41 3.28e-12 Gut microbiome composition (summer); CESC trans rs116095464 0.558 rs7356561 chr5:284381 G/C cg00938859 chr5:1591904 SDHAP3 0.65 7.03 0.4 1.73e-11 Breast cancer; CESC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.73 -0.38 1.03e-10 Electroencephalogram traits; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09008928 chr6:24667597 ACOT13;TTRAP -0.46 -6.13 -0.35 3.2e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs4595586 0.679 rs35743713 chr12:39318539 C/G cg26384229 chr12:38710491 ALG10B 0.45 6.69 0.38 1.36e-10 Morning vs. evening chronotype; CESC cis rs6754311 0.731 rs748841 chr2:136558157 C/T cg07169764 chr2:136633963 MCM6 -0.66 -8.09 -0.45 2.12e-14 Mosquito bite size; CESC cis rs4454254 0.736 rs11779476 chr8:141065953 T/C cg06693505 chr8:141057453 TRAPPC9 -0.34 -5.83 -0.34 1.57e-8 Pulse pressure; CESC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg18099408 chr3:52552593 STAB1 -0.36 -6.11 -0.35 3.63e-9 Electroencephalogram traits; CESC cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg18512352 chr11:47633146 NA -0.61 -9.33 -0.5 4.47e-18 Subjective well-being; CESC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg06028605 chr16:24865363 SLC5A11 -0.48 -7.12 -0.4 9.85e-12 Intelligence (multi-trait analysis); CESC cis rs7772486 0.875 rs9390371 chr6:146363180 A/G cg05347473 chr6:146136440 FBXO30 0.48 6.51 0.37 3.73e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg07747251 chr5:1868357 NA 0.31 5.21 0.3 3.89e-7 Cardiovascular disease risk factors; CESC cis rs7631605 0.905 rs9832423 chr3:37176116 A/G cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.14 -0.3 5.38e-7 Cerebrospinal P-tau181p levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13609937 chr9:133588314 ABL1 0.66 7.36 0.41 2.26e-12 Gut microbiome composition (summer); CESC cis rs7772486 0.790 rs2250387 chr6:146205233 C/T cg05347473 chr6:146136440 FBXO30 0.56 7.22 0.41 5.39e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg10896456 chr17:42255109 ASB16;C17orf65 -0.49 -7.29 -0.41 3.63e-12 Total body bone mineral density; CESC cis rs854765 0.551 rs6502626 chr17:17849450 C/T cg09796270 chr17:17721594 SREBF1 0.4 5.46 0.32 1.07e-7 Total body bone mineral density; CESC trans rs57221529 0.766 rs17497684 chr5:558307 T/C cg25482853 chr8:67687455 SGK3 1.11 11.94 0.59 1.39e-26 Lung disease severity in cystic fibrosis; CESC cis rs3857067 0.967 rs899135 chr4:95019816 C/A cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.53 -0.42 8.12e-13 QT interval; CESC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg07507251 chr3:52567010 NT5DC2 0.35 6.12 0.35 3.44e-9 Bipolar disorder; CESC cis rs3820928 0.845 rs13415319 chr2:227878936 G/C cg11843606 chr2:227700838 RHBDD1 -0.45 -5.62 -0.33 4.9e-8 Pulmonary function; CESC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg07952391 chr2:88470173 THNSL2 0.63 6.17 0.35 2.55e-9 Plasma clusterin levels; CESC cis rs2380220 0.872 rs115871915 chr6:95934180 T/C cg15832292 chr6:96025679 MANEA -0.64 -5.71 -0.33 2.99e-8 Behavioural disinhibition (generation interaction); CESC cis rs17253792 0.822 rs75995456 chr14:56073194 A/G cg01858014 chr14:56050164 KTN1 -0.93 -7.33 -0.41 2.71e-12 Putamen volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05254078 chr15:34502482 C15orf29 0.55 6.04 0.35 5.08e-9 Gut microbiome composition (summer); CESC cis rs11690935 0.959 rs35391289 chr2:172634983 A/C cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.08 -0.65 5.31e-34 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22295628 chr17:1733433 RPA1;SMYD4 0.54 6.14 0.35 3.06e-9 Gut microbiome composition (summer); CESC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg00750074 chr16:89608354 SPG7 -0.44 -6.39 -0.37 7.45e-10 Multiple myeloma (IgH translocation); CESC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg04414720 chr1:150670196 GOLPH3L 0.62 8.86 0.48 1.21e-16 Tonsillectomy; CESC trans rs561341 0.769 rs8074383 chr17:30178793 C/T cg27661571 chr11:113659931 NA 0.66 6.04 0.35 5.3300000000000004e-09 Hip circumference adjusted for BMI; CESC cis rs17253792 0.822 rs10142497 chr14:56047948 C/T cg24579896 chr14:56047964 C14orf33;KTN1 -0.85 -6.54 -0.37 3.2e-10 Putamen volume; CESC cis rs708547 0.874 rs1614251 chr4:57891386 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.67 7.71 0.43 2.47e-13 Response to bleomycin (chromatid breaks); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01776877 chr11:86666372 FZD4 0.55 6.56 0.37 2.75e-10 Gut microbiome composition (summer); CESC cis rs9902453 1.000 rs12600855 chr17:28279591 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 8.49 0.46 1.53e-15 Coffee consumption (cups per day); CESC trans rs6987853 0.830 rs4361746 chr8:42355041 C/T cg27650678 chr11:66636318 PC -0.46 -6.11 -0.35 3.45e-9 Mean corpuscular hemoglobin concentration; CESC cis rs1395 0.744 rs62130709 chr2:27505782 C/T cg22903471 chr2:27725779 GCKR -0.5 -6.08 -0.35 4.12e-9 Blood metabolite levels; CESC cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg02592271 chr2:27665507 KRTCAP3 -0.32 -6.29 -0.36 1.28e-9 Total body bone mineral density; CESC cis rs929354 0.713 rs7798816 chr7:156940574 A/G cg05182265 chr7:156933206 UBE3C -0.49 -7.03 -0.4 1.76e-11 Body mass index; CESC cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg19717773 chr7:2847554 GNA12 -0.56 -8.77 -0.47 2.14e-16 Height; CESC cis rs3812762 0.912 rs10769953 chr11:8778352 A/G cg03980550 chr11:8754370 ST5 0.35 5.03 0.3 8.9e-7 Hypospadias; CESC cis rs941873 0.868 rs4980063 chr10:81105844 A/T cg08514558 chr10:81106712 PPIF 0.33 5.63 0.33 4.5e-8 Height; CESC cis rs35955747 0.871 rs2013254 chr22:31690803 G/A cg25791279 chr22:32026902 PISD -0.5 -6.01 -0.35 6.17e-9 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs8062405 1.000 rs28403629 chr16:28854769 A/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9815354 0.812 rs73071328 chr3:41810055 A/C cg03022575 chr3:42003672 ULK4 0.68 6.06 0.35 4.7e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs4561483 0.864 rs190461 chr16:12005745 A/G cg08843971 chr16:11963173 GSPT1 -0.42 -5.72 -0.33 2.9e-8 Testicular germ cell tumor; CESC cis rs17433780 0.808 rs12125301 chr1:89508501 G/A cg09516651 chr1:89888402 LOC400759 0.7 10.59 0.55 4.26e-22 Carotid intima media thickness; CESC cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg10523679 chr1:76189770 ACADM 0.75 10.03 0.52 2.82e-20 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg17971929 chr21:40555470 PSMG1 -0.59 -7.3 -0.41 3.4e-12 Menarche (age at onset); CESC cis rs13191362 0.872 rs67712738 chr6:163245768 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.24 0.31 3.3e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4664293 1.000 rs10204535 chr2:160463692 C/T cg08347373 chr2:160653686 CD302 -0.31 -5.07 -0.3 7.41e-7 Monocyte percentage of white cells; CESC cis rs1707322 0.927 rs6690386 chr1:46253011 C/T cg06784218 chr1:46089804 CCDC17 0.38 6.59 0.38 2.37e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7178572 1.000 rs952471 chr15:77776498 C/G cg22256960 chr15:77711686 NA -0.6 -8.09 -0.44 2.19e-14 Type 2 diabetes; CESC cis rs12476592 0.602 rs6708804 chr2:63807269 G/A cg17519650 chr2:63277830 OTX1 -0.46 -5.22 -0.31 3.57e-7 Childhood ear infection; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12049088 chr22:36784491 MYH9 -0.43 -6.06 -0.35 4.65e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg12463550 chr7:65579703 CRCP -0.5 -6.34 -0.36 9.71e-10 Aortic root size; CESC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg11890956 chr21:40555474 PSMG1 -0.61 -8.43 -0.46 2.25e-15 Menarche (age at onset); CESC cis rs4835473 0.897 rs11100802 chr4:144621199 A/G cg25736465 chr4:144833511 NA -0.36 -5.32 -0.31 2.18e-7 Immature fraction of reticulocytes; CESC cis rs2806561 0.808 rs12128178 chr1:23354814 C/T cg12483005 chr1:23474871 LUZP1 -0.34 -5.33 -0.31 2.06e-7 Height; CESC cis rs4481887 0.741 rs6682953 chr1:248535626 T/C cg26353448 chr1:248524236 OR2T4 -0.38 -5.38 -0.31 1.67e-7 Common traits (Other); CESC cis rs2635047 0.967 rs2684843 chr18:44726260 T/A cg19077165 chr18:44547161 KATNAL2 -0.44 -5.98 -0.35 7.03e-9 Educational attainment; CESC cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.76 11.13 0.56 7.1e-24 Monocyte percentage of white cells; CESC cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg24209194 chr3:40518798 ZNF619 0.43 5.68 0.33 3.55e-8 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21005948 chr18:46065258 KIAA0427 0.56 6.67 0.38 1.48e-10 Gut microbiome composition (summer); CESC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg26441486 chr22:50317300 CRELD2 0.42 5.25 0.31 3.07e-7 Schizophrenia; CESC cis rs11098499 0.863 rs3822190 chr4:120428098 G/A cg24375607 chr4:120327624 NA 0.44 5.25 0.31 3.13e-7 Corneal astigmatism; CESC cis rs2304069 0.601 rs216143 chr5:149444147 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.88 10.06 0.53 2.2e-20 HIV-1 control; CESC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.58 0.42 5.78e-13 Prudent dietary pattern; CESC cis rs568617 0.716 rs77779142 chr11:65599656 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.93 8.33 0.46 4.51e-15 Crohn's disease; CESC cis rs6912958 0.559 rs107690 chr6:88069352 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.73 -11.18 -0.57 4.97e-24 Monocyte percentage of white cells; CESC cis rs4704187 0.687 rs4704196 chr5:74537606 A/G cg03227963 chr5:74354835 NA 0.27 5.04 0.3 8.67e-7 Response to amphetamines; CESC cis rs854765 0.583 rs8080823 chr17:17864048 T/C cg04398451 chr17:18023971 MYO15A -0.67 -9.28 -0.5 6.3e-18 Total body bone mineral density; CESC cis rs911186 0.786 rs3800307 chr6:27185792 A/T cg12292205 chr6:26970375 C6orf41 -0.55 -6.27 -0.36 1.47e-9 Autism spectrum disorder or schizophrenia; CESC cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg11752832 chr7:134001865 SLC35B4 0.54 7.01 0.4 1.96e-11 Mean platelet volume; CESC trans rs1459104 0.571 rs10459012 chr11:55091574 C/A cg15704280 chr7:45808275 SEPT13 0.58 6.04 0.35 5.24e-9 Body mass index; CESC trans rs801193 0.844 rs7779971 chr7:66161790 T/C cg26939375 chr7:64535504 NA 0.64 8.77 0.47 2.19e-16 Aortic root size; CESC cis rs7772486 0.875 rs932522 chr6:146374026 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.99 -0.39 2.18e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs4141404 0.818 rs5997897 chr22:31570436 G/A cg13145458 chr22:31556086 RNF185 0.46 5.79 0.34 1.94e-8 Paclitaxel-induced neuropathy; CESC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg07507251 chr3:52567010 NT5DC2 0.41 7.11 0.4 1.05e-11 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12897799 chr12:65175296 NA -0.56 -6.27 -0.36 1.45e-9 Gut microbiome composition (summer); CESC cis rs3126085 0.935 rs1858479 chr1:152294823 A/T cg03465714 chr1:152285911 FLG 0.5 5.71 0.33 2.96e-8 Atopic dermatitis; CESC cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg00074818 chr8:8560427 CLDN23 0.38 5.46 0.32 1.1e-7 Obesity-related traits; CESC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg22638593 chr5:131593259 PDLIM4 0.4 5.22 0.31 3.69e-7 Breast cancer; CESC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg24642844 chr7:1081250 C7orf50 -0.75 -8.99 -0.48 4.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs10716881 1 rs10716881 chr12:57038170 GA/G cg05584118 chr12:57595605 LRP1 0.36 5.13 0.3 5.63e-7 High light scatter reticulocyte count; CESC cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg23887609 chr12:130822674 PIWIL1 0.44 5.75 0.33 2.39e-8 Menopause (age at onset); CESC cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.64e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg27094323 chr7:1216898 NA -0.37 -5.03 -0.3 8.9e-7 Longevity;Endometriosis; CESC cis rs7818688 1.000 rs6989862 chr8:96027568 T/C cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg16325326 chr1:53192061 ZYG11B -0.89 -15.22 -0.68 5.28e-38 Monocyte count; CESC cis rs2066819 1.000 rs79824801 chr12:56728137 T/C cg26714650 chr12:56694279 CS -1.39 -9.17 -0.49 1.33e-17 Psoriasis vulgaris; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg02550200 chr17:5389462 MIS12;DERL2 0.54 6.07 0.35 4.52e-9 Psoriatic arthritis; CESC cis rs6800768 0.633 rs59374114 chr3:24112202 G/T cg10674438 chr3:24145617 LOC152024 -0.43 -5.98 -0.34 7.27e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7584330 0.704 rs72620820 chr2:238358844 G/A cg14458575 chr2:238380390 NA 0.88 11.24 0.57 3.14e-24 Prostate cancer; CESC cis rs4563143 0.514 rs55727361 chr19:29300415 A/T cg12756686 chr19:29218302 NA 0.53 6.18 0.35 2.42e-9 Methadone dose in opioid dependence; CESC cis rs4812048 0.649 rs6070706 chr20:57628239 C/T cg14073986 chr20:57617431 SLMO2 0.7 5.75 0.33 2.51e-8 Mean platelet volume; CESC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg26335602 chr6:28129616 ZNF389 0.37 5.52 0.32 7.92e-8 Cardiac Troponin-T levels; CESC cis rs1395 0.778 rs72810794 chr2:27401260 C/T cg22903471 chr2:27725779 GCKR -0.44 -5.41 -0.32 1.38e-7 Blood metabolite levels; CESC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.33 0.31 2.11e-7 Tonsillectomy; CESC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg06634786 chr22:41940651 POLR3H -0.67 -6.49 -0.37 4.13e-10 Vitiligo; CESC cis rs2777491 0.915 rs9302109 chr15:41612180 G/T cg02330683 chr15:41787940 ITPKA 0.45 6.56 0.37 2.73e-10 Ulcerative colitis; CESC cis rs2243480 1.000 rs316334 chr7:65602126 G/T cg13147721 chr7:65941812 NA -0.98 -9.24 -0.49 8.33e-18 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19263974 chr12:3103878 TEAD4 -0.62 -7.28 -0.41 3.71e-12 Gut microbiome composition (summer); CESC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg22920501 chr2:26401640 FAM59B -0.66 -7.9 -0.44 7.42e-14 Gut microbiome composition (summer); CESC cis rs72945132 0.882 rs72947012 chr11:70149472 G/A cg14191688 chr11:70257035 CTTN 0.47 5.65 0.33 4.1e-8 Coronary artery disease; CESC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg04369109 chr6:150039330 LATS1 -0.47 -6.47 -0.37 4.63e-10 Lung cancer; CESC trans rs875971 0.660 rs10215132 chr7:66054406 C/A cg26939375 chr7:64535504 NA -0.63 -8.53 -0.46 1.17e-15 Aortic root size; CESC cis rs12541635 0.934 rs11776139 chr8:106983966 A/G cg10147462 chr8:107024639 NA 0.41 5.62 0.33 4.83e-8 Age of smoking initiation; CESC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg18252515 chr7:66147081 NA 0.43 5.57 0.32 6.1e-8 Aortic root size; CESC cis rs4919694 0.808 rs80020194 chr10:105035954 A/G cg04362960 chr10:104952993 NT5C2 0.79 5.87 0.34 1.3e-8 Arsenic metabolism; CESC cis rs6598955 0.671 rs11247914 chr1:26648838 G/T cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.27 0.31 2.88e-7 Obesity-related traits; CESC cis rs7845219 0.544 rs34293080 chr8:95908078 G/T cg09323728 chr8:95962352 TP53INP1 -0.35 -6.89 -0.39 4.07e-11 Type 2 diabetes; CESC cis rs2050392 0.624 rs303435 chr10:30731491 T/C cg25182066 chr10:30743637 MAP3K8 -0.49 -6.5 -0.37 3.93e-10 Inflammatory bowel disease; CESC trans rs875971 0.619 rs12533585 chr7:65984605 G/C cg26939375 chr7:64535504 NA 0.64 8.73 0.47 2.82e-16 Aortic root size; CESC cis rs6665290 0.901 rs3795453 chr1:227205331 A/G cg10327440 chr1:227177885 CDC42BPA -1.15 -24.28 -0.83 2.41e-69 Myeloid white cell count; CESC trans rs11039798 0.544 rs114343057 chr11:48558172 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.67 0.38 1.46e-10 Axial length; CESC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg18016565 chr1:150552671 MCL1 0.36 5.35 0.31 1.93e-7 Tonsillectomy; CESC cis rs6813479 0.523 rs2932114 chr4:137744095 G/A cg16185213 chr4:137733633 NA 0.37 5.05 0.3 8.19e-7 Longevity; CESC cis rs11723261 0.582 rs6599293 chr4:133027 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.5 6.49 0.37 4.3e-10 Immune response to smallpox vaccine (IL-6); CESC cis rs6088580 0.634 rs6059905 chr20:33126946 T/C cg06115741 chr20:33292138 TP53INP2 0.47 5.92 0.34 1.01e-8 Glomerular filtration rate (creatinine); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18358588 chr6:26660131 ZNF322A 0.53 6.56 0.37 2.83e-10 Gut microbiome composition (summer); CESC cis rs3824867 0.879 rs10742806 chr11:47456226 T/A cg20307385 chr11:47447363 PSMC3 0.5 6.09 0.35 3.87e-9 Mean corpuscular hemoglobin; CESC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg17747265 chr1:1875780 NA -0.57 -9.18 -0.49 1.24e-17 Body mass index; CESC cis rs7818688 1.000 rs10103841 chr8:96025904 T/G cg16049864 chr8:95962084 TP53INP1 0.6 5.77 0.33 2.25e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg04025307 chr7:1156635 C7orf50 0.55 9.79 0.52 1.64e-19 Longevity;Endometriosis; CESC cis rs10791097 0.694 rs11222369 chr11:130744670 A/G cg12179176 chr11:130786555 SNX19 0.64 9.86 0.52 9.69e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg18876405 chr7:65276391 NA -0.53 -7.22 -0.41 5.6e-12 Aortic root size; CESC cis rs17376456 1.000 rs59472588 chr5:93511981 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.65 5.58 0.32 6.01e-8 Diabetic retinopathy; CESC cis rs1153858 0.887 rs7171163 chr15:45636395 A/C cg21132104 chr15:45694354 SPATA5L1 0.82 11.02 0.56 1.72e-23 Homoarginine levels; CESC cis rs6963495 0.745 rs818620 chr7:105172685 G/C cg13798780 chr7:105162888 PUS7 0.62 7.14 0.4 8.93e-12 Bipolar disorder (body mass index interaction); CESC cis rs2439831 0.850 rs11070408 chr15:44034788 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.68 0.38 1.43e-10 Lung cancer in ever smokers; CESC cis rs1950500 0.565 rs3181248 chr14:24808168 G/A cg16194253 chr14:24768981 DHRS1;C14orf21 0.55 6.75 0.38 9.16e-11 Height; CESC cis rs6942756 0.744 rs2718088 chr7:128927020 C/A cg02491457 chr7:128862824 NA 0.62 8.66 0.47 4.73e-16 White matter hyperintensity burden; CESC trans rs2727020 0.538 rs61885230 chr11:49128958 T/C cg00717180 chr2:96193071 NA -0.52 -7.24 -0.41 4.77e-12 Coronary artery disease; CESC cis rs11098499 0.644 rs6855918 chr4:120546299 C/T cg09307838 chr4:120376055 NA 0.74 9.88 0.52 8.51e-20 Corneal astigmatism; CESC cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg04455712 chr21:45112962 RRP1B 0.4 5.93 0.34 9.32e-9 Mean corpuscular volume; CESC cis rs3733418 0.860 rs72697987 chr4:165953917 G/A cg10852876 chr4:165953100 TRIM60 -0.47 -5.48 -0.32 1.01e-7 Obesity-related traits; CESC cis rs881375 0.678 rs7021049 chr9:123683982 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 7.31 0.41 3.22e-12 Rheumatoid arthritis; CESC cis rs11608355 0.545 rs34737994 chr12:109901621 C/T cg05360138 chr12:110035743 NA 0.81 8.84 0.48 1.41e-16 Neuroticism; CESC cis rs4523957 0.788 rs11078865 chr17:2109109 T/A cg16513277 chr17:2031491 SMG6 -0.59 -7.94 -0.44 5.92e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.65e-39 Menopause (age at onset); CESC cis rs10838687 0.736 rs2306353 chr11:47256708 C/T cg25783544 chr11:47291846 MADD 0.56 6.47 0.37 4.81e-10 Proinsulin levels; CESC cis rs12122100 0.507 rs1925343 chr1:146505535 A/T cg02487331 chr1:146550467 NA -0.37 -5.75 -0.33 2.47e-8 HIV-1 control; CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg09747232 chr8:103827049 NA 0.55 6.42 0.37 6.27e-10 Endometrial cancer; CESC cis rs7602441 0.521 rs78567942 chr2:14767845 C/A cg06545361 chr2:14773388 FAM84A 0.71 6.88 0.39 4.38e-11 Visceral adipose tissue adjusted for BMI; CESC cis rs10979 1.000 rs9386032 chr6:143887492 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC cis rs66573146 1.000 rs66573146 chr4:6984464 C/G cg00086871 chr4:6988644 TBC1D14 1.11 6.36 0.36 8.97e-10 Granulocyte percentage of myeloid white cells; CESC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg07395648 chr5:131743802 NA -0.4 -5.22 -0.31 3.67e-7 Breast cancer; CESC cis rs8027181 0.617 rs12439200 chr15:73086731 A/G cg25632853 chr15:73088954 NA 0.4 6.14 0.35 3e-9 Triglyceride levels; CESC trans rs7943203 1.000 rs61913875 chr11:108298852 A/G cg24643211 chr18:11851603 GNAL;CHMP1B -0.47 -6.05 -0.35 4.93e-9 Red blood cell count;Mean corpuscular volume; CESC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg23758822 chr17:41437982 NA 1.05 16.36 0.71 4.52e-42 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09994017 chr10:75118319 TTC18 -0.46 -6.4 -0.37 6.94e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg18099408 chr3:52552593 STAB1 -0.3 -5.03 -0.3 9.03e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08222185 chr21:46494823 ADARB1 0.6 7.05 0.4 1.54e-11 Gut microbiome composition (summer); CESC cis rs11638352 0.661 rs2615269 chr15:44427956 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.56 5.29 0.31 2.53e-7 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC cis rs684232 0.666 rs2657629 chr17:602261 G/T cg15660573 chr17:549704 VPS53 -0.67 -9.37 -0.5 3.26e-18 Prostate cancer; CESC cis rs116095464 0.558 rs9312977 chr5:221916 G/C cg10591111 chr5:226296 SDHA -0.51 -6.35 -0.36 9.22e-10 Breast cancer; CESC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 12.68 0.61 4e-29 Gut microbiome composition (summer); CESC cis rs12971120 0.947 rs8084109 chr18:72168312 T/A cg25817165 chr18:72167213 CNDP2 -0.56 -7.72 -0.43 2.34e-13 Refractive error; CESC cis rs9302635 0.513 rs3812987 chr16:72158920 C/A cg01557791 chr16:72042693 DHODH -0.62 -7.3 -0.41 3.4e-12 Blood protein levels; CESC trans rs9929218 1.000 rs9928847 chr16:68797893 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.44 -0.46 2.1e-15 Colorectal cancer; CESC cis rs7937682 0.883 rs1784775 chr11:111472460 T/C cg09085632 chr11:111637200 PPP2R1B -0.94 -13.87 -0.65 2.84e-33 Primary sclerosing cholangitis; CESC cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 3.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.66 6.37 0.36 8.45e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs11098499 0.913 rs10010696 chr4:120164303 T/C cg24375607 chr4:120327624 NA 0.43 5.18 0.3 4.31e-7 Corneal astigmatism; CESC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg17949981 chr6:28129498 ZNF389 0.45 5.62 0.33 4.9e-8 Depression; CESC cis rs72781680 0.898 rs17762651 chr2:24115922 A/G cg20701182 chr2:24300061 SF3B14 0.63 5.65 0.33 4.07e-8 Lymphocyte counts; CESC cis rs10129255 0.957 rs8005468 chr14:107142448 C/T cg23076370 chr14:107095027 NA -0.44 -5.47 -0.32 1.06e-7 Kawasaki disease; CESC cis rs8028182 0.549 rs7402293 chr15:75636137 A/G cg20655648 chr15:75932815 IMP3 -0.42 -5.29 -0.31 2.52e-7 Sudden cardiac arrest; CESC cis rs6083 0.571 rs41294813 chr15:58847807 T/C cg05156742 chr15:59063176 FAM63B -0.7 -9.92 -0.52 6.14e-20 Schizophrenia; CESC cis rs854765 0.616 rs8076747 chr17:17853595 C/T cg04398451 chr17:18023971 MYO15A -0.72 -10.51 -0.54 7.97e-22 Total body bone mineral density; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg02442412 chr4:83720054 SCD5 -0.43 -6.09 -0.35 3.86e-9 Recombination measurement; CESC cis rs2204008 0.684 rs11514164 chr12:38036494 C/T cg13010199 chr12:38710504 ALG10B 0.47 5.83 0.34 1.62e-8 Bladder cancer; CESC cis rs68170813 0.559 rs76299183 chr7:106904859 A/G cg02696742 chr7:106810147 HBP1 -0.54 -5.33 -0.31 2.15e-7 Coronary artery disease; CESC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg12311346 chr5:56204834 C5orf35 -0.54 -7.23 -0.41 5.33e-12 Coronary artery disease; CESC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg12034118 chr1:209979487 IRF6 0.46 5.37 0.31 1.68e-7 Cleft lip with or without cleft palate; CESC cis rs1577917 0.771 rs9362237 chr6:86409064 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.58 8.01 0.44 3.58e-14 Response to antipsychotic treatment; CESC cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg03433033 chr1:76189801 ACADM 0.64 6.49 0.37 4.22e-10 Blood metabolite levels;Acylcarnitine levels; CESC cis rs56399783 0.901 rs73051415 chr7:2850643 C/T cg19731401 chr7:2775893 GNA12 0.63 5.42 0.32 1.32e-7 Childhood ear infection; CESC cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg22903471 chr2:27725779 GCKR -0.57 -8.18 -0.45 1.2e-14 Total body bone mineral density; CESC cis rs1790761 0.505 rs6591256 chr11:67349899 A/G cg14500267 chr11:67383377 NA -0.32 -5.34 -0.31 2.02e-7 Mean corpuscular volume; CESC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg05552183 chr6:42928497 GNMT 0.82 13.72 0.64 1.01e-32 Alzheimer's disease in APOE e4+ carriers; CESC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg19717773 chr7:2847554 GNA12 -0.56 -7.92 -0.44 6.66e-14 Height; CESC cis rs9324022 0.858 rs1004573 chr14:101178235 G/C cg18089426 chr14:101175970 NA 0.61 7.68 0.43 3.15e-13 Plateletcrit; CESC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg23102388 chr7:1867652 MAD1L1 -0.33 -5.05 -0.3 8.16e-7 Bipolar disorder and schizophrenia; CESC cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg09555818 chr19:45449301 APOC2 0.39 6.22 0.36 1.88e-9 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27323088 chr5:89770393 MBLAC2;POLR3G 0.61 7.08 0.4 1.32e-11 Gut microbiome composition (summer); CESC cis rs9457247 1.000 rs405553 chr6:167395058 A/G cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC cis rs941207 0.526 rs7303216 chr12:57074693 A/C cg05584118 chr12:57595605 LRP1 -0.37 -5.04 -0.3 8.53e-7 Platelet count; CESC cis rs35306767 0.903 rs11253504 chr10:956046 A/G cg20503657 chr10:835505 NA 0.9 9.27 0.49 6.58e-18 Eosinophil percentage of granulocytes; CESC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg11301795 chr4:187892539 NA -0.75 -11.49 -0.58 4.49e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs17376456 0.569 rs6556834 chr5:93123067 C/T cg25358565 chr5:93447407 FAM172A -0.71 -7.57 -0.42 6.39e-13 Diabetic retinopathy; CESC cis rs7208859 0.623 rs11652631 chr17:29060766 A/G cg19761014 chr17:28927070 LRRC37B2 0.76 6.25 0.36 1.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg24549020 chr5:56110836 MAP3K1 0.59 6.95 0.39 2.75e-11 Initial pursuit acceleration; CESC trans rs61148964 0.826 rs11913459 chr22:37228603 G/A cg08062273 chr3:45641120 LIMD1 0.59 6.18 0.35 2.41e-9 Scarlet fever; CESC cis rs965469 0.532 rs6115865 chr20:3359303 A/G cg25506879 chr20:3388711 C20orf194 0.42 5.15 0.3 5.05e-7 IFN-related cytopenia; CESC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg08859206 chr1:53392774 SCP2 -0.66 -9.63 -0.51 5.2e-19 Monocyte count; CESC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg24562669 chr7:97807699 LMTK2 0.49 6.87 0.39 4.57e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs4308124 0.708 rs28871990 chr2:111962441 G/A cg04571233 chr2:111982156 NA -0.64 -7.06 -0.4 1.47e-11 Vitiligo; CESC cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg19077165 chr18:44547161 KATNAL2 -0.65 -9.87 -0.52 8.73e-20 Personality dimensions; CESC trans rs7618501 0.665 rs7621352 chr3:50070763 A/C cg21659725 chr3:3221576 CRBN -0.52 -7.37 -0.41 2.22e-12 Intelligence (multi-trait analysis); CESC cis rs9393777 0.546 rs9366673 chr6:26893329 C/G cg12826209 chr6:26865740 GUSBL1 0.76 8.71 0.47 3.34e-16 Intelligence (multi-trait analysis); CESC cis rs7208859 0.623 rs7217984 chr17:29092766 G/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1707322 1.000 rs11211236 chr1:46443767 C/A cg06784218 chr1:46089804 CCDC17 0.33 5.63 0.33 4.7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7336332 0.628 rs9581854 chr13:28017782 C/T cg01674679 chr13:27998804 GTF3A -0.59 -5.25 -0.31 3.08e-7 Weight; CESC cis rs8014204 0.935 rs2300596 chr14:75353855 C/T cg08847533 chr14:75593920 NEK9 0.43 5.38 0.31 1.65e-7 Caffeine consumption; CESC cis rs7666738 0.546 rs11727151 chr4:98837353 A/C cg17366294 chr4:99064904 C4orf37 0.49 6.0 0.35 6.32e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9308731 0.591 rs10439396 chr2:111935976 T/A cg04202892 chr2:111875749 ACOXL 0.38 5.27 0.31 2.76e-7 Chronic lymphocytic leukemia; CESC cis rs2635047 0.811 rs17785603 chr18:44769534 T/A cg19077165 chr18:44547161 KATNAL2 -0.39 -5.11 -0.3 6.12e-7 Educational attainment; CESC cis rs9911578 0.740 rs368243 chr17:56708979 T/C cg05425664 chr17:57184151 TRIM37 -0.42 -5.63 -0.33 4.62e-8 Intelligence (multi-trait analysis); CESC trans rs11098499 0.954 rs28685688 chr4:120420334 T/C cg25214090 chr10:38739885 LOC399744 0.71 9.95 0.52 4.98e-20 Corneal astigmatism; CESC cis rs11190604 1.000 rs2495736 chr10:102338410 T/C cg07080220 chr10:102295463 HIF1AN 0.64 5.91 0.34 1.07e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs8060686 0.545 rs8057119 chr16:68268836 C/T cg26727032 chr16:67993705 SLC12A4 -0.49 -5.67 -0.33 3.79e-8 HDL cholesterol;Metabolic syndrome; CESC cis rs3749237 0.595 rs7621003 chr3:49411404 T/C cg03060546 chr3:49711283 APEH 0.75 11.29 0.57 2.23e-24 Resting heart rate; CESC trans rs17508449 0.775 rs4839336 chr1:114234145 A/T cg23028848 chr11:57092561 TNKS1BP1 -0.79 -6.28 -0.36 1.38e-9 Leprosy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02984193 chr15:91260561 BLM 0.57 6.94 0.39 3e-11 Gut microbiome composition (summer); CESC cis rs9359856 0.564 rs6914142 chr6:90398903 C/T cg13799429 chr6:90582589 CASP8AP2 -0.62 -6.13 -0.35 3.11e-9 Bipolar disorder; CESC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.54 -6.9 -0.39 3.91e-11 Tuberculosis; CESC cis rs12618769 0.597 rs72821907 chr2:99085296 A/G cg10123293 chr2:99228465 UNC50 0.38 5.04 0.3 8.64e-7 Bipolar disorder; CESC cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg05347473 chr6:146136440 FBXO30 0.58 7.43 0.42 1.48e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs478304 0.651 rs948494 chr11:65552118 G/A cg10518572 chr11:65560635 OVOL1 -0.31 -5.76 -0.33 2.37e-8 Acne (severe); CESC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs6964587 0.692 rs10236483 chr7:91797296 A/C cg01689657 chr7:91764605 CYP51A1 0.27 5.37 0.31 1.69e-7 Breast cancer; CESC cis rs7786808 0.782 rs7787923 chr7:158227312 A/G cg01191920 chr7:158217561 PTPRN2 -0.36 -6.3 -0.36 1.24e-9 Obesity-related traits; CESC cis rs7524258 0.900 rs6577426 chr1:7306451 A/G cg07173049 chr1:7289937 CAMTA1 0.35 5.38 0.31 1.64e-7 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs116095464 0.510 rs60844864 chr5:267000 A/G cg20965017 chr5:231967 SDHA -0.49 -5.41 -0.32 1.44e-7 Breast cancer; CESC cis rs28647808 1.000 rs4962140 chr9:136272507 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.9 5.73 0.33 2.75e-8 Blood protein levels; CESC cis rs2502731 1.000 rs2502731 chr9:130976557 A/G cg13642260 chr9:130955380 CIZ1 -0.58 -9.49 -0.5 1.44e-18 Attention deficit hyperactivity disorder; CESC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg22029157 chr1:209979665 IRF6 0.76 8.86 0.48 1.18e-16 Cleft lip with or without cleft palate; CESC cis rs12956009 0.583 rs11663609 chr18:44862757 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 6.6 0.38 2.25e-10 Educational attainment (years of education); CESC cis rs1401999 1.000 rs1402003 chr3:183642879 C/T cg01324343 chr3:183735012 ABCC5 0.62 13.18 0.63 7.52e-31 Anterior chamber depth; CESC cis rs9488822 0.676 rs12154016 chr6:116355188 C/T cg15226275 chr6:116381976 FRK 0.25 6.31 0.36 1.16e-9 Cholesterol, total;LDL cholesterol; CESC cis rs1538970 0.774 rs67683090 chr1:45977803 T/G cg24296786 chr1:45957014 TESK2 -0.46 -5.15 -0.3 4.97e-7 Platelet count; CESC cis rs1008375 0.966 rs2302393 chr4:17654341 G/A cg15017067 chr4:17643749 FAM184B 0.36 5.1 0.3 6.56e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07172676 chr8:144997714 PLEC1 0.5 6.94 0.39 2.95e-11 Fibrinogen levels; CESC cis rs72901758 0.768 rs1567237 chr17:76246294 A/G cg23302638 chr17:76210176 BIRC5 -0.47 -5.33 -0.31 2.13e-7 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs8067354 0.645 rs16943838 chr17:57839604 C/T cg13753209 chr17:57696993 CLTC 0.56 6.1 0.35 3.83e-9 Hemoglobin concentration; CESC cis rs2249694 0.960 rs4133041 chr10:135408387 G/A cg19469447 chr10:135341870 CYP2E1 0.37 5.18 0.3 4.42e-7 Obesity-related traits; CESC cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.76e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2242116 0.796 rs4587 chr3:46963502 T/C cg27129171 chr3:47204927 SETD2 0.52 6.52 0.37 3.53e-10 Birth weight; CESC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg02931644 chr1:25747376 RHCE 0.43 7.29 0.41 3.51e-12 Erythrocyte sedimentation rate; CESC cis rs7100689 0.753 rs1572816 chr10:82137600 A/G cg00277334 chr10:82204260 NA -0.58 -7.29 -0.41 3.66e-12 Post bronchodilator FEV1; CESC cis rs7937682 0.889 rs551825 chr11:111480116 C/G cg09085632 chr11:111637200 PPP2R1B -0.95 -14.72 -0.67 3.09e-36 Primary sclerosing cholangitis; CESC cis rs7827545 0.545 rs57219802 chr8:135554231 C/T cg17885191 chr8:135476712 NA 0.58 6.27 0.36 1.42e-9 Hypertension (SNP x SNP interaction); CESC cis rs7666738 0.830 rs11725652 chr4:98878362 G/A cg17366294 chr4:99064904 C4orf37 0.55 7.72 0.43 2.46e-13 Colonoscopy-negative controls vs population controls; CESC cis rs644799 0.635 rs10831428 chr11:95508404 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.75 11.2 0.57 4.24e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9814567 0.752 rs4955542 chr3:134328740 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.08 -0.3 6.97e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs66573146 0.656 rs66517061 chr4:6935163 C/G cg00086871 chr4:6988644 TBC1D14 0.95 5.18 0.3 4.33e-7 Granulocyte percentage of myeloid white cells; CESC cis rs11126435 0.591 rs10779958 chr2:74755778 A/C cg11955373 chr2:74710513 TTC31;CCDC142 0.55 5.29 0.31 2.57e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg06808227 chr14:105710500 BRF1 -0.54 -6.24 -0.36 1.69e-9 Mean platelet volume;Platelet distribution width; CESC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg05368731 chr17:41323189 NBR1 0.77 10.67 0.55 2.32e-22 Menopause (age at onset); CESC cis rs4253772 0.591 rs9627324 chr22:46656511 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.17 0.45 1.28e-14 LDL cholesterol;Cholesterol, total; CESC cis rs6736093 0.966 rs2271701 chr2:112731173 C/G cg12686935 chr2:112915763 FBLN7 -0.42 -5.51 -0.32 8.65e-8 Coronary artery disease; CESC cis rs7937682 0.883 rs2212520 chr11:111462096 C/T cg22437258 chr11:111473054 SIK2 0.71 9.19 0.49 1.16e-17 Primary sclerosing cholangitis; CESC trans rs2727020 0.556 rs2866365 chr11:49390731 A/G cg15704280 chr7:45808275 SEPT13 -0.82 -9.67 -0.51 3.85e-19 Coronary artery disease; CESC trans rs7937682 0.855 rs521947 chr11:111492616 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.01 0.35 6.26e-9 Primary sclerosing cholangitis; CESC cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 8.79 0.47 1.99e-16 Hip circumference adjusted for BMI; CESC trans rs2727020 0.729 rs4315497 chr11:49214499 G/A cg15704280 chr7:45808275 SEPT13 0.85 14.1 0.65 4.49e-34 Coronary artery disease; CESC trans rs9951602 0.512 rs4798994 chr18:76654327 T/G cg02800362 chr5:177631904 HNRNPAB 0.66 8.63 0.47 5.9e-16 Obesity-related traits; CESC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.75 0.38 9.49e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg02891314 chr5:179741120 GFPT2 -0.57 -7.77 -0.43 1.78e-13 Height; CESC cis rs68170813 0.559 rs2107319 chr7:106863744 T/C cg02696742 chr7:106810147 HBP1 -0.54 -5.52 -0.32 7.95e-8 Coronary artery disease; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg22819824 chr10:115618670 NHLRC2 0.42 6.27 0.36 1.47e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs941408 1.000 rs1076447 chr19:2792128 C/G cg06609049 chr19:2785107 THOP1 0.73 10.39 0.54 2.02e-21 Total cholesterol levels; CESC trans rs7582180 0.700 rs1437971 chr2:100986964 A/C cg17205461 chr7:27779758 TAX1BP1 0.6 6.02 0.35 5.94e-9 Intelligence (multi-trait analysis); CESC cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg13104385 chr7:22767384 IL6 0.42 5.79 0.33 2.01e-8 Lung cancer; CESC cis rs314370 0.855 rs76181418 chr7:100494960 G/T cg10426581 chr7:100472382 SRRT 0.84 8.18 0.45 1.23e-14 Resting heart rate; CESC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg03352830 chr11:487213 PTDSS2 0.7 6.71 0.38 1.16e-10 Body mass index; CESC cis rs9549367 0.826 rs9549710 chr13:113898064 A/C cg00898013 chr13:113819073 PROZ -0.52 -7.07 -0.4 1.36e-11 Platelet distribution width; CESC cis rs1707322 1.000 rs4660318 chr1:46334876 A/G cg05343316 chr1:45956843 TESK2 0.44 5.55 0.32 7.05e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4141404 0.706 rs5753698 chr22:31970054 A/C cg00478049 chr22:31556069 RNF185 -0.45 -5.34 -0.31 1.98e-7 Paclitaxel-induced neuropathy; CESC cis rs1538970 0.924 rs11211108 chr1:45891152 C/T cg03146154 chr1:46216737 IPP 0.44 5.09 0.3 6.74e-7 Platelet count; CESC cis rs731174 0.802 rs12123842 chr1:38187989 T/C cg12339802 chr1:38156545 C1orf109 -0.55 -5.57 -0.32 6.11e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs13191362 0.507 rs2846566 chr6:163059714 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.58 -6.91 -0.39 3.68e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg23422044 chr7:1970798 MAD1L1 -0.5 -5.41 -0.32 1.43e-7 Bipolar disorder; CESC cis rs28489187 0.577 rs729655 chr1:85844617 A/C cg16011679 chr1:85725395 C1orf52 0.44 5.22 0.31 3.62e-7 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs7833986 0.501 rs2953909 chr8:56968200 T/C cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.16 0.3 4.9e-7 Height; CESC cis rs1580019 0.961 rs958217 chr7:32493417 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.76 10.45 0.54 1.27e-21 Cognitive ability; CESC cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg04455712 chr21:45112962 RRP1B 0.51 7.86 0.43 9.96e-14 Mean corpuscular volume; CESC trans rs7937682 0.889 rs11213969 chr11:111528441 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.19 0.36 2.22e-9 Primary sclerosing cholangitis; CESC cis rs7605827 0.930 rs7575290 chr2:15597322 C/T cg19274914 chr2:15703543 NA 0.33 5.97 0.34 7.72e-9 Educational attainment (years of education); CESC cis rs1018836 0.828 rs9297871 chr8:91572731 G/A cg16814680 chr8:91681699 NA -0.62 -8.98 -0.48 5.22e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg26314531 chr2:26401878 FAM59B 0.7 7.94 0.44 5.58e-14 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.48 0.32 9.95e-8 Colonoscopy-negative controls vs population controls; CESC cis rs17376456 0.825 rs66564678 chr5:93165894 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.38 0.31 1.66e-7 Diabetic retinopathy; CESC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg10691866 chr7:65817282 TPST1 -0.34 -5.47 -0.32 1.06e-7 Aortic root size; CESC cis rs10733682 0.659 rs3906146 chr9:129463613 C/T cg00232160 chr9:129468157 NA 0.42 6.54 0.37 3.17e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6430585 0.702 rs73958637 chr2:136546927 C/T cg07169764 chr2:136633963 MCM6 1.29 17.4 0.73 9.47e-46 Corneal structure; CESC trans rs1814175 0.645 rs1721996 chr11:49915527 G/A cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs9287719 0.967 rs7563816 chr2:10763400 C/T cg02196655 chr2:10830764 NOL10 -0.37 -5.56 -0.32 6.58e-8 Prostate cancer; CESC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg13012494 chr21:47604986 C21orf56 -0.48 -6.43 -0.37 6.02e-10 Testicular germ cell tumor; CESC cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.19 0.3 4.19e-7 Hip circumference adjusted for BMI; CESC cis rs75477785 1.000 rs12063989 chr1:210049893 T/C cg02304930 chr1:210405566 SERTAD4;C1orf133 0.79 5.15 0.3 5.08e-7 Cleft lip with or without cleft palate; CESC cis rs9399135 0.967 rs6908512 chr6:135367757 A/G cg24558204 chr6:135376177 HBS1L 0.5 6.85 0.39 5.16e-11 Red blood cell count; CESC cis rs67460515 0.852 rs2404341 chr3:161092405 T/C cg03342759 chr3:160939853 NMD3 -0.54 -7.64 -0.42 3.94e-13 Parkinson's disease; CESC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg13206674 chr6:150067644 NUP43 0.43 5.98 0.34 7.33e-9 Lung cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg07656391 chr2:32264720 DPY30 0.48 6.6 0.38 2.29e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11785400 0.793 rs4581034 chr8:143736968 G/A cg10596483 chr8:143751796 JRK 0.43 5.43 0.32 1.31e-7 Schizophrenia; CESC cis rs1003719 0.715 rs2251952 chr21:38559711 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.51 -6.71 -0.38 1.18e-10 Eye color traits; CESC cis rs8114671 0.562 rs7266550 chr20:33495510 C/T cg07148914 chr20:33460835 GGT7 0.46 6.13 0.35 3.19e-9 Height; CESC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg00149659 chr3:10157352 C3orf10 0.74 8.67 0.47 4.4e-16 Alzheimer's disease; CESC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg18404041 chr3:52824283 ITIH1 -0.37 -6.66 -0.38 1.6e-10 Bipolar disorder; CESC cis rs5769765 0.773 rs4075331 chr22:50302850 A/G cg26441486 chr22:50317300 CRELD2 0.39 5.19 0.3 4.1e-7 Schizophrenia; CESC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.73 0.55 1.51e-22 Height; CESC cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.75 0.47 2.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg04317338 chr11:64019027 PLCB3 0.85 8.72 0.47 3.12e-16 Mean platelet volume; CESC cis rs1364505 0.575 rs732490 chr7:132014616 T/C cg03295361 chr7:131864608 PLXNA4 -0.37 -5.04 -0.3 8.61e-7 Venous thromboembolism (SNP x SNP interaction); CESC trans rs55704346 0.566 rs10027825 chr4:25386599 G/A cg01822600 chr1:245751692 KIF26B 0.42 6.17 0.35 2.58e-9 Tonsillectomy; CESC cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg20476274 chr7:133979776 SLC35B4 0.65 9.41 0.5 2.53e-18 Mean platelet volume; CESC cis rs1008375 0.606 rs6828925 chr4:17561139 C/T cg02297831 chr4:17616191 MED28 0.43 5.45 0.32 1.13e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg18876405 chr7:65276391 NA 0.49 5.38 0.31 1.63e-7 Aortic root size; CESC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg04414720 chr1:150670196 GOLPH3L 0.51 6.8 0.39 6.73e-11 Melanoma; CESC cis rs10791097 0.694 rs7106973 chr11:130758113 G/A cg12179176 chr11:130786555 SNX19 0.64 9.86 0.52 9.65e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7809950 0.817 rs4727678 chr7:107083635 C/G cg23024343 chr7:107201750 COG5 -0.56 -7.2 -0.4 6.06e-12 Coronary artery disease; CESC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg05863683 chr7:1912471 MAD1L1 0.39 5.67 0.33 3.67e-8 Bipolar disorder and schizophrenia; CESC cis rs1499972 0.618 rs61384494 chr3:117640660 C/T cg07612923 chr3:117604196 NA 0.68 6.27 0.36 1.45e-9 Schizophrenia; CESC cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg08645402 chr16:4508243 NA 0.44 6.43 0.37 6.05e-10 Schizophrenia; CESC cis rs9287719 0.967 rs7593496 chr2:10738176 A/C cg02196655 chr2:10830764 NOL10 -0.37 -5.72 -0.33 2.87e-8 Prostate cancer; CESC cis rs6831352 0.879 rs1230154 chr4:99988659 C/T cg13256891 chr4:100009986 ADH5 0.65 7.94 0.44 5.92e-14 Alcohol dependence; CESC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg04166393 chr7:2884313 GNA12 0.59 7.33 0.41 2.87e-12 Height; CESC cis rs7474896 0.583 rs1208770 chr10:38044683 C/T cg00409905 chr10:38381863 ZNF37A -0.46 -5.03 -0.3 9.04e-7 Obesity (extreme); CESC cis rs61841072 0.808 rs61842502 chr1:243127288 A/G cg02356786 chr1:243265016 LOC731275 0.4 5.03 0.3 9.1e-7 Schizophrenia; CESC cis rs6598955 0.627 rs12143920 chr1:26575834 A/G cg19743891 chr1:26644573 UBXN11;CD52 0.37 5.19 0.3 4.16e-7 Obesity-related traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24185116 chr15:52044314 LYSMD2;TMOD2 -0.5 -7.03 -0.4 1.79e-11 Gut microbiota (bacterial taxa); CESC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg15782153 chr7:917662 C7orf20 0.56 8.35 0.46 3.95e-15 Perceived unattractiveness to mosquitoes; CESC cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.21e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC cis rs4689388 0.856 rs3200 chr4:6304878 C/T cg14416269 chr4:6271139 WFS1 0.49 8.21 0.45 9.71e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs7980799 0.905 rs4244866 chr12:33511983 G/C cg26384229 chr12:38710491 ALG10B -0.45 -6.12 -0.35 3.3e-9 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs1729951 0.546 rs12054219 chr3:136677472 G/A cg03617693 chr3:136751559 NA 0.38 5.26 0.31 3.02e-7 Neuroticism; CESC cis rs16917546 0.935 rs10822050 chr10:64438771 T/C cg03961010 chr10:64397487 ZNF365 -0.32 -5.34 -0.31 1.97e-7 Basal cell carcinoma; CESC cis rs1707322 0.656 rs2991981 chr1:46057144 A/G cg05343316 chr1:45956843 TESK2 -0.55 -6.78 -0.38 7.74e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs854765 0.551 rs6502626 chr17:17849450 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.1 0.35 3.78e-9 Total body bone mineral density; CESC cis rs4595586 1.000 rs3803020 chr12:39233771 A/G cg26384229 chr12:38710491 ALG10B -0.38 -5.31 -0.31 2.32e-7 Morning vs. evening chronotype; CESC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg13628971 chr7:2884303 GNA12 0.62 7.99 0.44 4.05e-14 Height; CESC trans rs7448080 0.510 rs1875500 chr5:123246522 A/G cg10971134 chr1:56877429 NA -0.91 -6.4 -0.37 7.02e-10 Alcohol dependence (age at onset); CESC cis rs9287719 0.967 rs1541574 chr2:10773508 A/T cg00105475 chr2:10696890 NA 0.37 5.2 0.3 4.04e-7 Prostate cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11938120 chr5:56110761 MAP3K1 0.48 6.02 0.35 5.78e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg21782813 chr7:2030301 MAD1L1 0.49 6.78 0.38 7.76e-11 Bipolar disorder and schizophrenia; CESC cis rs1580019 0.961 rs1868777 chr7:32494076 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.53 5.59 0.32 5.54e-8 Cognitive ability; CESC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.68 -0.51 3.46e-19 Alzheimer's disease; CESC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.71e-40 Aortic root size; CESC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.72 0.62 2.99e-29 Alzheimer's disease; CESC cis rs6582630 0.519 rs8189561 chr12:38296178 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs2304069 0.545 rs12153714 chr5:149395254 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.47 6.36 0.36 8.69e-10 HIV-1 control; CESC cis rs9354308 0.802 rs2814102 chr6:66523230 A/G cg07460842 chr6:66804631 NA 0.51 5.57 0.32 6.14e-8 Metabolite levels; CESC cis rs9488822 0.702 rs6909746 chr6:116352750 C/T cg18764771 chr6:116381957 FRK 0.23 5.6 0.33 5.42e-8 Cholesterol, total;LDL cholesterol; CESC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg23758822 chr17:41437982 NA 1.03 15.5 0.69 5.3e-39 Menopause (age at onset); CESC cis rs2204008 0.729 rs2892365 chr12:38446760 G/C cg26384229 chr12:38710491 ALG10B -0.63 -9.48 -0.5 1.55e-18 Bladder cancer; CESC cis rs4566357 0.576 rs6750845 chr2:227911037 T/G cg11843606 chr2:227700838 RHBDD1 -0.47 -6.49 -0.37 4.32e-10 Coronary artery disease; CESC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg04944784 chr2:26401820 FAM59B 0.96 10.83 0.55 7.34e-23 Gut microbiome composition (summer); CESC cis rs2932538 1.000 rs2932538 chr1:113216543 A/G cg22162597 chr1:113214053 CAPZA1 -0.57 -7.2 -0.4 6.14e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs8180040 0.967 rs807935 chr3:47321669 A/G cg27129171 chr3:47204927 SETD2 0.66 10.09 0.53 1.82e-20 Colorectal cancer; CESC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg24675658 chr1:53192096 ZYG11B -0.54 -7.03 -0.4 1.71e-11 Monocyte count; CESC trans rs9650657 0.571 rs11783247 chr8:10788875 C/T cg15556689 chr8:8085844 FLJ10661 -0.56 -6.87 -0.39 4.7e-11 Neuroticism; CESC cis rs2635047 0.638 rs2571010 chr18:44652130 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 5.51 0.32 8.4e-8 Educational attainment; CESC cis rs2109514 0.967 rs4730743 chr7:116145957 A/T cg12739419 chr7:116140593 CAV2 -0.35 -6.48 -0.37 4.44e-10 Prevalent atrial fibrillation; CESC cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg05340658 chr4:99064831 C4orf37 0.82 12.66 0.61 4.8e-29 Colonoscopy-negative controls vs population controls; CESC cis rs9300255 0.602 rs884548 chr12:123634122 A/G cg05973401 chr12:123451056 ABCB9 0.51 5.72 0.33 2.81e-8 Neutrophil percentage of white cells; CESC cis rs863345 0.625 rs10489833 chr1:158490451 C/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC cis rs55692411 0.517 rs13095697 chr3:50136463 G/A cg24308560 chr3:49941425 MST1R -0.52 -6.39 -0.37 7.28e-10 Intelligence (multi-trait analysis); CESC cis rs4604732 0.631 rs12080860 chr1:247623053 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 6.04 0.35 5.19e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg16325326 chr1:53192061 ZYG11B -0.72 -11.75 -0.59 6.36e-26 Monocyte count; CESC cis rs3820928 1.000 rs11692572 chr2:227774503 C/G cg11843606 chr2:227700838 RHBDD1 -0.45 -5.96 -0.34 7.99e-9 Pulmonary function; CESC cis rs2115630 0.645 rs3825877 chr15:85174631 G/A cg11189052 chr15:85197271 WDR73 -0.5 -6.84 -0.39 5.31e-11 P wave terminal force; CESC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg10691866 chr7:65817282 TPST1 -0.33 -5.3 -0.31 2.43e-7 Aortic root size; CESC cis rs712039 0.652 rs853196 chr17:35848659 A/T cg16670864 chr17:35848621 DUSP14 0.47 6.02 0.35 5.78e-9 Tuberculosis; CESC cis rs909002 1.000 rs2292993 chr1:32140733 C/T cg13919466 chr1:32135498 COL16A1 -0.5 -9.02 -0.48 4.04e-17 Intelligence (multi-trait analysis); CESC cis rs1784581 0.761 rs7741581 chr6:162435250 C/T cg17173639 chr6:162384350 PARK2 0.6 9.33 0.5 4.55e-18 Itch intensity from mosquito bite; CESC cis rs6840258 0.825 rs72667747 chr4:87922063 C/T cg08197287 chr4:87952173 AFF1 -0.42 -5.33 -0.31 2.12e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs7605827 0.893 rs35123590 chr2:15708639 T/C cg19274914 chr2:15703543 NA 0.29 5.22 0.31 3.7e-7 Educational attainment (years of education); CESC cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg13628971 chr7:2884303 GNA12 0.43 5.59 0.32 5.52e-8 Height; CESC cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg07936489 chr17:37558343 FBXL20 0.75 10.45 0.54 1.24e-21 Glomerular filtration rate (creatinine); CESC cis rs2933343 0.729 rs1680794 chr3:128620390 A/G cg11901034 chr3:128598214 ACAD9 -0.39 -5.71 -0.33 3.06e-8 IgG glycosylation; CESC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.42 6.88 0.39 4.25e-11 Personality dimensions; CESC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg18180107 chr4:99064573 C4orf37 0.43 5.59 0.32 5.69e-8 Colonoscopy-negative controls vs population controls; CESC cis rs11098499 0.863 rs2291185 chr4:120434833 C/A cg24375607 chr4:120327624 NA 0.43 5.19 0.3 4.27e-7 Corneal astigmatism; CESC cis rs6499255 0.762 rs12325186 chr16:69658807 A/T cg15192750 chr16:69999425 NA 0.58 6.48 0.37 4.54e-10 IgE levels; CESC cis rs1594829 0.553 rs2046224 chr8:26151604 G/T cg11498726 chr8:26250323 BNIP3L -0.41 -6.12 -0.35 3.44e-9 Height; CESC cis rs9309711 0.772 rs9309715 chr2:3492318 C/G cg10845886 chr2:3471009 TTC15 0.79 10.56 0.54 5.55e-22 Neurofibrillary tangles; CESC cis rs3733585 0.781 rs13103879 chr4:9972879 T/C cg11266682 chr4:10021025 SLC2A9 -0.61 -12.23 -0.6 1.47e-27 Cleft plate (environmental tobacco smoke interaction); CESC cis rs5758659 1.000 rs134900 chr22:42683343 C/G cg15557168 chr22:42548783 NA -0.46 -7.42 -0.41 1.57e-12 Cognitive function; CESC cis rs1178968 0.818 rs4717084 chr7:72764541 C/T cg25889504 chr7:72793014 NA 0.48 5.06 0.3 7.68e-7 Triglyceride levels; CESC cis rs9623117 0.915 rs6001765 chr22:40498156 A/T cg05033341 chr22:40419857 FAM83F -0.43 -5.1 -0.3 6.47e-7 Prostate cancer (SNP x SNP interaction);Prostate cancer; CESC cis rs9926296 0.681 rs12923946 chr16:89821080 C/T cg03388025 chr16:89894329 SPIRE2 0.3 5.11 0.3 6.28e-7 Vitiligo; CESC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg18876405 chr7:65276391 NA 0.5 6.66 0.38 1.61e-10 Aortic root size; CESC cis rs2282802 0.685 rs1347143 chr5:139669386 A/G cg26211634 chr5:139558579 C5orf32 -0.5 -7.33 -0.41 2.85e-12 Intelligence (multi-trait analysis); CESC cis rs3747547 0.892 rs3747545 chr9:37916164 C/T cg13774184 chr9:37916125 SHB -0.72 -5.96 -0.34 7.81e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs3091242 0.933 rs9438904 chr1:25756860 T/C cg02931644 chr1:25747376 RHCE 0.4 6.54 0.37 3.15e-10 Erythrocyte sedimentation rate; CESC cis rs3540 0.960 rs8040585 chr15:91026477 T/C cg22089800 chr15:90895588 ZNF774 0.41 5.09 0.3 6.64e-7 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs6709815 0.841 rs6740004 chr2:219663153 G/A cg02176678 chr2:219576539 TTLL4 -0.38 -6.62 -0.38 1.93e-10 Reticulocyte count;High light scatter reticulocyte count; CESC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg25072359 chr17:41440525 NA 0.5 6.75 0.38 9.44e-11 Menopause (age at onset); CESC cis rs721399 0.719 rs4646254 chr8:18262059 A/G cg18736775 chr8:18248649 NAT2 -0.5 -5.5 -0.32 8.82e-8 Blood metabolite levels; CESC cis rs796364 0.806 rs11689664 chr2:201099961 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.78 -6.44 -0.37 5.52e-10 Schizophrenia; CESC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg24829409 chr8:58192753 C8orf71 -0.53 -6.91 -0.39 3.62e-11 Developmental language disorder (linguistic errors); CESC cis rs4423214 1.000 rs2040323 chr11:71172783 A/C cg05163923 chr11:71159392 DHCR7 0.86 11.46 0.58 5.92e-25 Vitamin D levels; CESC cis rs67311347 1.000 rs2887995 chr3:40409029 C/G cg09455208 chr3:40491958 NA 0.45 7.8 0.43 1.45e-13 Renal cell carcinoma; CESC trans rs1223629 1.000 rs56204274 chr10:95941639 A/G cg16346422 chr11:2920819 SLC22A18;SLC22A18AS 0.67 6.04 0.35 5.08e-9 Glucose homeostasis traits; CESC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg24549020 chr5:56110836 MAP3K1 0.66 7.56 0.42 6.6e-13 Initial pursuit acceleration; CESC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg18240062 chr17:79603768 NPLOC4 -0.72 -10.27 -0.53 4.71e-21 Eye color traits; CESC cis rs2455799 0.613 rs7620787 chr3:15882826 G/A cg16303742 chr3:15540471 COLQ -0.37 -5.55 -0.32 6.91e-8 Mean platelet volume; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12498409 chr7:40174463 C7orf10;C7orf11 -0.44 -6.07 -0.35 4.31e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg17971929 chr21:40555470 PSMG1 1.05 16.62 0.71 5.49e-43 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06376129 chr1:205180539 DSTYK 0.53 6.32 0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs6546537 0.840 rs34743816 chr2:69813345 A/C cg10773587 chr2:69614142 GFPT1 -0.58 -7.27 -0.41 4.07e-12 Serum thyroid-stimulating hormone levels; CESC cis rs11764590 0.666 rs7787359 chr7:2090849 A/G cg21782813 chr7:2030301 MAD1L1 -0.42 -5.31 -0.31 2.35e-7 Neuroticism; CESC cis rs11112613 0.713 rs12316204 chr12:105944244 G/A cg03607813 chr12:105948248 NA 0.65 7.81 0.43 1.33e-13 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg20151795 chr6:28129481 ZNF389 0.44 5.74 0.33 2.6e-8 Depression; CESC cis rs9911578 1.000 rs12453049 chr17:56611372 C/T cg05425664 chr17:57184151 TRIM37 0.5 7.06 0.4 1.5e-11 Intelligence (multi-trait analysis); CESC cis rs9467711 0.584 rs34244947 chr6:26761745 T/C cg21479132 chr6:26055353 NA 0.71 5.25 0.31 3.1e-7 Autism spectrum disorder or schizophrenia; CESC cis rs7618501 1.000 rs11130218 chr3:49752372 C/T cg24308560 chr3:49941425 MST1R 0.51 7.13 0.4 9.72e-12 Intelligence (multi-trait analysis); CESC cis rs4472734 0.813 rs4394613 chr1:214622818 A/G cg00063699 chr1:214624242 PTPN14 -0.32 -5.08 -0.3 7.05e-7 Height; CESC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg05890377 chr2:74357713 NA 0.78 10.7 0.55 1.9e-22 Gestational age at birth (maternal effect); CESC cis rs8180040 0.966 rs34634681 chr3:47579102 G/A cg27129171 chr3:47204927 SETD2 -0.62 -9.06 -0.49 2.87e-17 Colorectal cancer; CESC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg27170947 chr2:26402098 FAM59B -0.72 -8.31 -0.45 5.18e-15 Gut microbiome composition (summer); CESC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg17718321 chr1:152188247 HRNR -0.53 -8.66 -0.47 4.78e-16 Inflammatory skin disease; CESC cis rs11792861 0.619 rs2289480 chr9:111705501 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.61 9.39 0.5 2.83e-18 Menarche (age at onset); CESC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg20999797 chr1:1681921 NA 0.29 5.5 0.32 8.98e-8 Body mass index; CESC cis rs6061231 0.631 rs2427317 chr20:60975725 C/T cg24112000 chr20:60950667 NA -0.54 -8.45 -0.46 1.94e-15 Colorectal cancer; CESC cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.83 0.34 1.61e-8 Hip circumference adjusted for BMI; CESC cis rs1008375 0.932 rs4698629 chr4:17608884 C/G cg16339924 chr4:17578868 LAP3 0.52 5.85 0.34 1.44e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2425143 0.687 rs6119649 chr20:34369596 G/A cg23207816 chr20:34252616 CPNE1;RBM12 -0.72 -6.67 -0.38 1.52e-10 Blood protein levels; CESC cis rs6674176 0.660 rs6801 chr1:44396646 C/G cg23954153 chr1:44402353 ARTN 0.36 5.64 0.33 4.42e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs9611565 0.918 rs9611561 chr22:41757234 C/G cg03806693 chr22:41940476 POLR3H -1.03 -11.79 -0.59 4.34e-26 Vitiligo; CESC cis rs11235843 0.636 rs6592531 chr11:73412354 C/T cg18195628 chr11:73498948 MRPL48 -0.5 -5.49 -0.32 9.46e-8 Hand grip strength; CESC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg08888203 chr3:10149979 C3orf24 0.49 6.17 0.35 2.49e-9 Alzheimer's disease; CESC cis rs7116495 1.000 rs585228 chr11:71773289 G/C cg26138937 chr11:71823887 C11orf51 -0.83 -6.95 -0.39 2.81e-11 Severe influenza A (H1N1) infection; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03542721 chr8:22926253 TNFRSF10B -0.43 -7.03 -0.4 1.77e-11 Gambling; CESC cis rs10924309 0.882 rs10924305 chr1:245856763 A/G cg00036263 chr1:245852353 KIF26B 0.47 5.79 0.34 1.97e-8 Response to serotonin reuptake inhibitors in non-psychotic unipolar depression; CESC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg18099408 chr3:52552593 STAB1 -0.32 -5.4 -0.31 1.47e-7 Electroencephalogram traits; CESC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg23758822 chr17:41437982 NA 1.02 15.36 0.69 1.61e-38 Menopause (age at onset); CESC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg18876405 chr7:65276391 NA -0.53 -7.2 -0.4 6.28e-12 Aortic root size; CESC cis rs7520050 0.966 rs12410071 chr1:46358886 T/C cg03146154 chr1:46216737 IPP -0.45 -5.71 -0.33 2.99e-8 Red blood cell count;Reticulocyte count; CESC cis rs921968 0.643 rs596076 chr2:219451015 T/G cg02176678 chr2:219576539 TTLL4 0.42 7.29 0.41 3.59e-12 Mean corpuscular hemoglobin concentration; CESC cis rs11229555 1.000 rs2276153 chr11:58407740 C/G cg15696309 chr11:58395628 NA -0.43 -5.6 -0.33 5.43e-8 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs4853525 0.522 rs6744420 chr2:191589082 A/G cg10560079 chr2:191398806 TMEM194B 0.45 5.68 0.33 3.62e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg20600704 chr10:85899064 GHITM 0.45 6.15 0.35 2.9e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.6 0.38 2.18e-10 Bipolar disorder; CESC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.54 8.23 0.45 8.69e-15 Total body bone mineral density; CESC cis rs7208859 0.623 rs56018041 chr17:29059985 G/A cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9362426 1.000 rs9450662 chr6:88088593 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.5 6.32 0.36 1.11e-9 Depressive episodes in bipolar disorder; CESC cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg25208724 chr1:156163844 SLC25A44 1.01 19.07 0.76 1.21e-51 Testicular germ cell tumor; CESC cis rs4891159 0.757 rs11665518 chr18:74147054 C/T cg24786174 chr18:74118243 ZNF516 -0.72 -10.94 -0.56 3.02e-23 Longevity; CESC cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg01475377 chr6:109611718 NA -0.42 -6.43 -0.37 6.01e-10 Reticulocyte fraction of red cells; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23129613 chr7:150065255 REPIN1 -0.43 -6.3 -0.36 1.23e-9 Gambling; CESC cis rs9457247 1.000 rs9457247 chr6:167392174 C/T cg25258033 chr6:167368657 RNASET2 0.39 5.87 0.34 1.31e-8 Crohn's disease; CESC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg18876405 chr7:65276391 NA -0.45 -6.18 -0.35 2.43e-9 Aortic root size; CESC cis rs501120 0.925 rs1746052 chr10:44778546 G/T cg09554077 chr10:44749378 NA -0.55 -6.62 -0.38 1.98e-10 Coronary artery disease;Coronary heart disease; CESC cis rs9660992 0.573 rs1172147 chr1:205225457 G/A cg21643547 chr1:205240462 TMCC2 -0.42 -5.83 -0.34 1.57e-8 Mean corpuscular volume;Mean platelet volume; CESC cis rs9902453 0.967 rs12150261 chr17:28320473 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -8.69 -0.47 3.76e-16 Coffee consumption (cups per day); CESC cis rs3859192 0.599 rs2302777 chr17:38179492 A/G cg17467752 chr17:38218738 THRA -0.44 -5.92 -0.34 1.01e-8 White blood cell count; CESC cis rs9287719 0.967 rs728282 chr2:10750303 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.79 -0.34 1.96e-8 Prostate cancer; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg18170098 chr16:71880032 ATXN1L 0.45 6.37 0.36 8.14e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.592 rs57102627 chr22:41987627 T/C cg03806693 chr22:41940476 POLR3H -0.87 -10.5 -0.54 8.63e-22 Vitiligo; CESC cis rs1348850 0.558 rs4337505 chr2:178529714 A/T cg22681709 chr2:178499509 PDE11A -0.47 -6.85 -0.39 5.19e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs887829 0.609 rs7597496 chr2:234630443 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -5.83 -0.34 1.59e-8 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CESC cis rs1642645 0.831 rs10736422 chr1:42480320 C/T cg16685388 chr1:42384056 HIVEP3 0.39 5.81 0.34 1.75e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs9926296 0.632 rs4785716 chr16:89801127 T/C cg27121462 chr16:89883253 FANCA 0.64 8.22 0.45 9.36e-15 Vitiligo; CESC cis rs3096299 0.933 rs2965938 chr16:89491336 C/T cg02034447 chr16:89574710 SPG7 0.4 5.04 0.3 8.84e-7 Multiple myeloma (IgH translocation); CESC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg25934064 chr3:52569026 NT5DC2 0.27 5.68 0.33 3.5e-8 Electroencephalogram traits; CESC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg11890956 chr21:40555474 PSMG1 0.98 16.61 0.71 6.1e-43 Cognitive function; CESC cis rs12477438 0.520 rs6739579 chr2:99731552 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.87 0.7 2.48e-40 Chronic sinus infection; CESC trans rs9467711 0.606 rs1978 chr6:26377573 A/T cg06606381 chr12:133084897 FBRSL1 -0.72 -6.48 -0.37 4.35e-10 Autism spectrum disorder or schizophrenia; CESC cis rs4835473 0.864 rs1849132 chr4:144879462 C/T cg25736465 chr4:144833511 NA 0.41 6.11 0.35 3.59e-9 Immature fraction of reticulocytes; CESC trans rs7246760 1.000 rs12462027 chr19:9926860 G/A cg02900749 chr2:68251473 NA -0.81 -6.86 -0.39 4.95e-11 Pursuit maintenance gain; CESC cis rs919433 0.783 rs2565155 chr2:198236425 A/G cg20885578 chr2:198174922 NA 0.41 5.36 0.31 1.79e-7 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg23281280 chr6:28129359 ZNF389 0.4 5.94 0.34 9.03e-9 Cardiac Troponin-T levels; CESC cis rs6430585 0.527 rs7592050 chr2:136459227 C/T cg07169764 chr2:136633963 MCM6 -1.08 -12.57 -0.61 9.58e-29 Corneal structure; CESC cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg05347473 chr6:146136440 FBXO30 0.59 7.63 0.42 4.24e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs34779708 0.733 rs3936502 chr10:35549218 C/T cg04310649 chr10:35416472 CREM -0.45 -5.14 -0.3 5.34e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs17854409 0.803 rs1048100 chr20:61472073 C/A cg05147244 chr20:61493195 TCFL5 0.9 6.53 0.37 3.34e-10 Obesity-related traits; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07792822 chr1:157961914 KIRREL -0.44 -6.05 -0.35 4.84e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg27221266 chr10:96122679 NOC3L -0.44 -6.32 -0.36 1.12e-9 Gambling; CESC cis rs9527 0.590 rs34104646 chr10:104896078 T/A cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs10883723 0.810 rs7093028 chr10:104259417 A/G cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Allergic disease (asthma, hay fever or eczema); CESC trans rs2727020 0.554 rs2866490 chr11:49425463 A/G cg03929089 chr4:120376271 NA -0.67 -7.45 -0.42 1.31e-12 Coronary artery disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03193865 chr8:145510099 BOP1 0.5 6.64 0.38 1.75e-10 Fibrinogen levels; CESC cis rs2637266 1.000 rs2579750 chr10:78340260 C/G cg18941641 chr10:78392320 NA -0.42 -7.88 -0.44 8.29e-14 Pulmonary function; CESC cis rs11148252 0.595 rs4885325 chr13:53171317 C/T cg00495681 chr13:53174319 NA 0.61 8.44 0.46 2.08e-15 Lewy body disease; CESC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.59 -0.38 2.43e-10 Life satisfaction; CESC cis rs2011503 1.000 rs113527843 chr19:19643343 A/T cg11584989 chr19:19387371 SF4 0.58 6.67 0.38 1.52e-10 Bipolar disorder; CESC cis rs10782582 0.593 rs17647178 chr1:76210524 A/G cg22875332 chr1:76189707 ACADM -0.44 -5.24 -0.31 3.32e-7 Daytime sleep phenotypes; CESC cis rs72781680 0.898 rs17462670 chr2:24026579 T/C cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs478304 0.934 rs498354 chr11:65528213 A/G cg08755490 chr11:65554678 OVOL1 0.49 6.5 0.37 3.95e-10 Acne (severe); CESC cis rs7336332 0.598 rs76249173 chr13:28010445 A/G cg22138327 chr13:27999177 GTF3A 0.62 5.82 0.34 1.71e-8 Weight; CESC cis rs17362650 0.653 rs10929581 chr2:9552379 C/T cg12832956 chr2:9616023 IAH1 -0.55 -6.19 -0.36 2.33e-9 Alcohol dependence (age at onset); CESC cis rs1348850 0.914 rs4341974 chr2:178324879 A/C cg23306229 chr2:178417860 TTC30B 0.64 8.2 0.45 1.03e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg05283184 chr6:79620031 NA -0.43 -6.61 -0.38 2.06e-10 Intelligence (multi-trait analysis); CESC cis rs728616 0.681 rs55838345 chr10:82085120 G/C cg05935833 chr10:81318306 SFTPA2 -0.46 -5.75 -0.33 2.48e-8 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg13607699 chr17:42295918 UBTF -0.66 -8.17 -0.45 1.31e-14 Total body bone mineral density; CESC trans rs1814175 0.817 rs7481230 chr11:49772235 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.93 -0.77 1.26e-54 Height; CESC cis rs9549367 0.756 rs9549702 chr13:113881944 T/G cg18105134 chr13:113819100 PROZ -0.67 -8.45 -0.46 1.99e-15 Platelet distribution width; CESC cis rs2108225 0.934 rs4730269 chr7:107455719 T/G cg18560240 chr7:107437656 SLC26A3 -0.38 -5.05 -0.3 8.34e-7 Ulcerative colitis; CESC cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg10645314 chr2:3704589 ALLC -0.45 -5.06 -0.3 8.01e-7 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CESC trans rs4295623 0.789 rs12541318 chr8:11594970 G/T cg15556689 chr8:8085844 FLJ10661 -0.55 -6.08 -0.35 4.12e-9 Morning vs. evening chronotype; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26428032 chr11:67387935 NA -0.43 -6.95 -0.39 2.87e-11 Gut microbiota (bacterial taxa); CESC cis rs7107174 0.901 rs2512522 chr11:77925855 G/C cg02023728 chr11:77925099 USP35 0.47 6.43 0.37 5.9e-10 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23064501 chr12:42680748 NA -0.64 -7.76 -0.43 1.84e-13 Gut microbiome composition (summer); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg13883984 chr15:83621779 HOMER2 0.46 6.66 0.38 1.59e-10 Systemic lupus erythematosus; CESC cis rs7312933 0.933 rs4534650 chr12:42444222 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.41 5.44 0.32 1.24e-7 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs66887589 0.616 rs11731675 chr4:120212514 T/C cg09307838 chr4:120376055 NA 0.66 9.12 0.49 1.94e-17 Diastolic blood pressure; CESC cis rs11792861 0.564 rs3816237 chr9:111718348 T/A cg05043794 chr9:111880884 C9orf5 -0.3 -5.49 -0.32 9.36e-8 Menarche (age at onset); CESC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg13770153 chr20:60521292 NA 0.83 11.74 0.59 6.51e-26 Obesity-related traits; CESC cis rs4319547 0.656 rs2173582 chr12:122824694 A/G cg05707623 chr12:122985044 ZCCHC8 -0.49 -5.66 -0.33 3.95e-8 Body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00140813 chr16:28857836 TUFM 0.5 7.09 0.4 1.21e-11 Gut microbiota (bacterial taxa); CESC cis rs7000551 0.715 rs1879792 chr8:22314029 C/A cg12081754 chr8:22256438 SLC39A14 0.41 5.27 0.31 2.81e-7 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs113835537 0.597 rs4576 chr11:66331000 A/G cg22134325 chr11:66188745 NPAS4 0.37 5.63 0.33 4.58e-8 Airway imaging phenotypes; CESC cis rs12458462 0.859 rs2242177 chr18:77477379 G/A cg23301140 chr18:77439876 CTDP1 0.56 7.31 0.41 3.13e-12 Monocyte count; CESC cis rs2841277 0.741 rs9672139 chr14:105408182 T/G cg21017887 chr14:105400489 NA 0.4 6.48 0.37 4.5e-10 Rheumatoid arthritis; CESC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg22307029 chr19:49891270 CCDC155 0.7 8.41 0.46 2.52e-15 Multiple sclerosis; CESC cis rs4664304 0.658 rs2667016 chr2:160868855 C/T cg03641300 chr2:160917029 PLA2R1 -0.46 -6.53 -0.37 3.38e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs7932354 0.528 rs10838654 chr11:47095511 G/C cg25783544 chr11:47291846 MADD -0.42 -5.63 -0.33 4.62e-8 Bone mineral density (hip);Bone mineral density; CESC cis rs1215050 0.791 rs700738 chr4:98907909 C/A cg05340658 chr4:99064831 C4orf37 -0.49 -6.37 -0.36 8.15e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs2120019 1.000 rs8033837 chr15:75353975 A/C cg09165964 chr15:75287851 SCAMP5 -0.73 -8.56 -0.47 9.11e-16 Blood trace element (Zn levels); CESC cis rs3812049 0.826 rs34576922 chr5:127364103 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.9 -11.14 -0.56 6.93e-24 Lymphocyte counts;Red cell distribution width; CESC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg07701084 chr6:150067640 NUP43 0.43 5.78 0.33 2.13e-8 Lung cancer; CESC cis rs8070624 0.574 rs9914127 chr17:17875836 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.68 9.67 0.51 3.79e-19 Total body bone mineral density; CESC cis rs854765 0.964 rs12943202 chr17:17994332 T/A cg16928487 chr17:17741425 SREBF1 0.57 9.75 0.51 2.09e-19 Total body bone mineral density; CESC cis rs7666738 0.530 rs2865992 chr4:99067181 A/T cg17366294 chr4:99064904 C4orf37 0.43 5.62 0.33 4.86e-8 Colonoscopy-negative controls vs population controls; CESC cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg22508957 chr16:3507546 NAT15 -0.59 -9.57 -0.51 7.86e-19 Tuberculosis; CESC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg07414643 chr4:187882934 NA 0.54 7.9 0.44 7.51e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.583 rs11078406 chr17:17840823 G/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.3 0.36 1.24e-9 Total body bone mineral density; CESC cis rs6460942 0.659 rs6969309 chr7:12515847 T/C cg10578991 chr7:12443926 VWDE -0.48 -5.06 -0.3 7.85e-7 Coronary artery disease; CESC cis rs6088590 0.965 rs6088620 chr20:33412022 A/G cg24642439 chr20:33292090 TP53INP2 0.84 11.74 0.59 6.4e-26 Coronary artery disease; CESC cis rs854765 0.583 rs4341796 chr17:17839024 C/A cg04398451 chr17:18023971 MYO15A -0.66 -9.24 -0.49 8.32e-18 Total body bone mineral density; CESC trans rs7674118 0.850 rs10010647 chr4:166847150 G/A cg23810282 chr5:43037519 NA 0.67 6.02 0.35 5.77e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg03433033 chr1:76189801 ACADM 0.65 7.67 0.43 3.3e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3760982 0.585 rs67773424 chr19:44293994 G/A cg11993925 chr19:44307056 LYPD5 0.32 5.5 0.32 8.79e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs870825 0.616 rs72705689 chr4:185639894 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.09 0.4 1.21e-11 Blood protein levels; CESC cis rs6942756 1.000 rs11763056 chr7:128960871 C/A cg02491457 chr7:128862824 NA -0.68 -9.24 -0.49 8.31e-18 White matter hyperintensity burden; CESC cis rs7208859 0.614 rs216412 chr17:28903394 A/G cg04154034 chr17:28927549 LRRC37B2 -0.65 -6.18 -0.35 2.42e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9303401 1.000 rs9303401 chr17:56847945 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.73 9.6 0.51 6.34e-19 Cognitive test performance; CESC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg26314531 chr2:26401878 FAM59B -0.85 -9.04 -0.49 3.44e-17 Gut microbiome composition (summer); CESC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg18099408 chr3:52552593 STAB1 -0.31 -5.05 -0.3 8.09e-7 Bipolar disorder; CESC cis rs2708240 1.000 rs2538974 chr7:147587753 A/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.33 -5.33 -0.31 2.06e-7 QT interval (drug interaction); CESC cis rs2124969 0.548 rs62175388 chr2:161019664 G/A cg03641300 chr2:160917029 PLA2R1 -0.58 -6.01 -0.35 6.14e-9 Waist circumference adjusted for body mass index; CESC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg22823121 chr1:150693482 HORMAD1 0.44 6.11 0.35 3.48e-9 Melanoma; CESC cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg11764359 chr7:65958608 NA -0.79 -9.42 -0.5 2.25e-18 Aortic root size; CESC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.15 0.53 1.18e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg04315214 chr1:2043799 PRKCZ -0.44 -7.05 -0.4 1.53e-11 Height; CESC cis rs4722166 0.630 rs6461667 chr7:22796743 A/G cg13104385 chr7:22767384 IL6 0.43 5.53 0.32 7.75e-8 Lung cancer; CESC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg24846343 chr22:24311635 DDTL -0.59 -9.82 -0.52 1.33e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs77972916 0.609 rs13414381 chr2:43567218 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.56 -5.11 -0.3 6.16e-7 Granulocyte percentage of myeloid white cells; CESC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.56 0.37 2.83e-10 Prudent dietary pattern; CESC cis rs6570726 0.846 rs441575 chr6:145849205 A/C cg23711669 chr6:146136114 FBXO30 0.8 11.89 0.59 2e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs7949030 0.588 rs2512562 chr11:62312156 A/G cg11742103 chr11:62369870 EML3;MTA2 0.57 8.62 0.47 6.29e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs9914988 0.832 rs34267753 chr17:27157586 T/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg11812906 chr14:75593930 NEK9 0.83 13.51 0.64 5.28e-32 Height; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg08568075 chr14:105220026 SIVA1 -0.47 -6.32 -0.36 1.07e-9 Height; CESC cis rs2777491 0.872 rs61037359 chr15:41585926 T/C cg18705301 chr15:41695430 NDUFAF1 -0.6 -9.19 -0.49 1.19e-17 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08292080 chr16:56398010 AMFR -0.56 -6.82 -0.39 6.11e-11 Gut microbiome composition (summer); CESC cis rs3008870 1.000 rs3008874 chr1:67431365 A/T cg02640540 chr1:67518911 SLC35D1 0.51 5.58 0.32 5.89e-8 Lymphocyte percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14452650 chr2:42396274 EML4 0.6 6.49 0.37 4.27e-10 Gut microbiome composition (summer); CESC cis rs11945232 1.000 rs4314250 chr4:88340969 A/G cg23841344 chr4:88312519 HSD17B11 0.6 7.41 0.41 1.72e-12 Intelligence (multi-trait analysis); CESC cis rs3825932 0.961 rs10400881 chr15:79234384 G/C cg25744700 chr15:79237217 CTSH 0.48 6.46 0.37 5.05e-10 Type 1 diabetes; CESC cis rs72945132 0.619 rs34053053 chr11:70260598 C/T cg00319359 chr11:70116639 PPFIA1 0.62 5.59 0.32 5.67e-8 Coronary artery disease; CESC trans rs2155929 0.660 rs12956304 chr18:26609858 T/C cg25413575 chr17:80870577 TBCD -0.38 -6.0 -0.35 6.63e-9 Temperament (bipolar disorder); CESC trans rs60843830 1.000 rs55936726 chr2:258210 T/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 8.49 0.46 1.51e-15 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs10504229 0.871 rs7002070 chr8:58153817 A/G cg24829409 chr8:58192753 C8orf71 -0.62 -8.1 -0.45 1.99e-14 Developmental language disorder (linguistic errors); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15312298 chr8:127570908 FAM84B -0.41 -6.23 -0.36 1.78e-9 Gambling; CESC cis rs4888262 0.526 rs4404098 chr16:74570050 G/A cg01733217 chr16:74700730 RFWD3 0.73 9.93 0.52 5.99e-20 Testicular germ cell tumor; CESC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg09365446 chr1:150670422 GOLPH3L 0.41 5.82 0.34 1.73e-8 Urate levels; CESC trans rs7726839 0.507 rs60068988 chr5:597668 T/C cg25482853 chr8:67687455 SGK3 1.04 10.08 0.53 1.87e-20 Obesity-related traits; CESC cis rs4835473 0.864 rs61427459 chr4:144620758 C/T cg25736465 chr4:144833511 NA -0.35 -5.22 -0.31 3.65e-7 Immature fraction of reticulocytes; CESC cis rs7827545 1.000 rs4909910 chr8:135565201 T/C cg17885191 chr8:135476712 NA 0.48 6.28 0.36 1.39e-9 Hypertension (SNP x SNP interaction); CESC cis rs854765 0.547 rs9897761 chr17:17912011 A/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.54 7.23 0.41 5.11e-12 Total body bone mineral density; CESC cis rs2180341 1.000 rs9388561 chr6:127634921 C/T cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6.31e-39 Breast cancer; CESC cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs5753618 0.583 rs5749268 chr22:31809152 G/A cg02404636 chr22:31891804 SFI1 0.39 5.37 0.31 1.71e-7 Colorectal cancer; CESC trans rs11098499 0.909 rs35111518 chr4:120440682 A/G cg25214090 chr10:38739885 LOC399744 0.71 9.72 0.51 2.74e-19 Corneal astigmatism; CESC cis rs9908102 0.710 rs8079762 chr17:12910795 T/C cg26162695 chr17:12921313 ELAC2 0.52 5.71 0.33 3.04e-8 Schizophrenia; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg03925809 chr19:6393419 GTF2F1 -0.45 -6.98 -0.39 2.37e-11 Vertical cup-disc ratio; CESC cis rs7582720 0.832 rs115194657 chr2:203829284 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs11214589 0.806 rs4551806 chr11:113250540 T/A cg14159747 chr11:113255604 NA 0.3 5.37 0.31 1.69e-7 Neuroticism; CESC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg21951975 chr1:209979733 IRF6 0.62 7.75 0.43 2.01e-13 Cleft lip with or without cleft palate; CESC cis rs72781680 0.611 rs4149373 chr2:24300023 C/T cg20701182 chr2:24300061 SF3B14 0.93 10.6 0.55 4.05e-22 Lymphocyte counts; CESC cis rs1348850 0.668 rs2365619 chr2:178497366 A/G cg23306229 chr2:178417860 TTC30B -0.6 -7.02 -0.4 1.82e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs763121 0.925 rs1056661 chr22:39080245 A/G cg21395723 chr22:39101663 GTPBP1 0.38 5.06 0.3 7.7e-7 Menopause (age at onset); CESC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg24846343 chr22:24311635 DDTL 0.66 11.31 0.57 1.91e-24 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.78 0.47 2.13e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7927771 1.000 rs12787330 chr11:47812311 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -6.04 -0.35 5.24e-9 Subjective well-being; CESC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg17372223 chr3:52568218 NT5DC2 0.44 6.56 0.37 2.82e-10 Bipolar disorder; CESC cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg24110177 chr3:50126178 RBM5 0.54 7.58 0.42 5.95e-13 Intelligence (multi-trait analysis); CESC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg23803603 chr1:2058230 PRKCZ -0.33 -5.89 -0.34 1.19e-8 Height; CESC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg21770322 chr7:97807741 LMTK2 0.55 8.08 0.44 2.32e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs4919694 1.000 rs17727391 chr10:104836101 C/A cg04362960 chr10:104952993 NT5C2 0.78 6.93 0.39 3.25e-11 Arsenic metabolism; CESC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg02038168 chr22:39784481 NA -0.53 -7.02 -0.4 1.84e-11 Intelligence (multi-trait analysis); CESC cis rs9583531 0.527 rs12875067 chr13:111365104 A/G cg24331049 chr13:111365604 ING1 0.73 10.94 0.56 3.01e-23 Coronary artery disease; CESC cis rs72634258 0.679 rs7523227 chr1:8180097 G/A cg00042356 chr1:8021962 PARK7 0.5 5.43 0.32 1.29e-7 Inflammatory bowel disease; CESC cis rs2228479 0.867 rs12930606 chr16:89946682 A/G cg14709524 chr16:89940631 TCF25 0.74 5.75 0.33 2.43e-8 Skin colour saturation; CESC cis rs4629710 0.592 rs749375 chr6:131553692 C/G cg12606694 chr6:131520996 AKAP7 0.5 6.11 0.35 3.45e-9 Multiple myeloma (IgH translocation); CESC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg18230493 chr5:56204884 C5orf35 -0.73 -8.57 -0.47 8.93e-16 Initial pursuit acceleration; CESC cis rs1729951 0.575 rs361245 chr3:136695706 A/G cg25687071 chr3:136751404 NA 0.39 5.23 0.31 3.47e-7 Neuroticism; CESC cis rs6541297 0.703 rs57992758 chr1:230314396 A/G cg20703242 chr1:230279135 GALNT2 -0.43 -5.6 -0.33 5.46e-8 Coronary artery disease; CESC cis rs2486288 0.656 rs8039153 chr15:45579813 T/C cg09092052 chr15:45571596 NA 0.45 5.38 0.31 1.62e-7 Glomerular filtration rate; CESC trans rs6011002 1.000 rs6011014 chr20:62300940 C/T cg02961472 chr15:70340064 NA 0.57 6.08 0.35 4.24e-9 Dental caries; CESC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg00409905 chr10:38381863 ZNF37A -0.5 -6.65 -0.38 1.65e-10 Extrinsic epigenetic age acceleration; CESC cis rs2439831 0.867 rs2412779 chr15:43655927 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.87 13.11 0.63 1.34e-30 Lung cancer in ever smokers; CESC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg07677032 chr17:61819896 STRADA 0.45 5.96 0.34 8.19e-9 Prudent dietary pattern; CESC cis rs9443189 0.570 rs7765254 chr6:76398143 T/C cg01950844 chr6:76311363 SENP6 0.93 8.52 0.46 1.26e-15 Prostate cancer; CESC cis rs1185460 0.967 rs4454730 chr11:118937444 G/A cg01677386 chr11:118938358 VPS11 -0.44 -5.64 -0.33 4.35e-8 Coronary artery disease; CESC cis rs113835537 0.529 rs60358007 chr11:66222353 G/A cg24851651 chr11:66362959 CCS 0.53 6.25 0.36 1.62e-9 Airway imaging phenotypes; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09622504 chr13:74708442 KLF12 -0.44 -6.14 -0.35 3.04e-9 Asthma; CESC cis rs10276381 0.786 rs10281102 chr7:28243473 A/G cg23620719 chr7:28220237 JAZF1 0.74 7.64 0.43 3.86e-13 Crohn's disease; CESC cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg17366294 chr4:99064904 C4orf37 0.58 8.25 0.45 7.41e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg18758796 chr5:131593413 PDLIM4 0.45 6.35 0.36 9.29e-10 Breast cancer; CESC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg19622623 chr12:86230825 RASSF9 -0.46 -5.97 -0.34 7.6e-9 Major depressive disorder; CESC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.54 -0.32 7.3900000000000007e-08 Prostate cancer (SNP x SNP interaction); CESC cis rs2294693 0.945 rs68031000 chr6:41008841 G/T cg14418226 chr6:40996092 UNC5CL 0.5 5.75 0.33 2.42e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs2625529 0.938 rs4238447 chr15:72131880 C/T cg16672083 chr15:72433130 SENP8 -0.42 -5.34 -0.31 2.01e-7 Red blood cell count; CESC cis rs709400 1.000 rs861538 chr14:104166733 C/T cg24130564 chr14:104152367 KLC1 -0.43 -5.48 -0.32 9.71e-8 Body mass index; CESC cis rs6582630 0.555 rs35284307 chr12:38509999 T/G cg26384229 chr12:38710491 ALG10B 0.7 10.5 0.54 8.9e-22 Drug-induced liver injury (flucloxacillin); CESC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg24549020 chr5:56110836 MAP3K1 0.65 7.54 0.42 7.42e-13 Initial pursuit acceleration; CESC cis rs6499255 0.951 rs10852457 chr16:69607853 C/T cg15192750 chr16:69999425 NA 0.49 5.84 0.34 1.55e-8 IgE levels; CESC cis rs9486715 0.867 rs9384602 chr6:96919561 G/A cg18709589 chr6:96969512 KIAA0776 0.46 6.47 0.37 4.83e-10 Headache; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg12410370 chr1:43296526 ERMAP 0.43 6.22 0.36 1.92e-9 Fibrinogen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15622697 chr1:201924833 TIMM17A 0.57 6.45 0.37 5.13e-10 Gut microbiome composition (summer); CESC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg23172400 chr8:95962367 TP53INP1 -0.43 -8.75 -0.47 2.62e-16 Type 2 diabetes; CESC cis rs73206853 0.841 rs73206870 chr12:110819953 T/C cg12870014 chr12:110450643 ANKRD13A 0.64 5.11 0.3 6.16e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC trans rs11088226 0.681 rs11700671 chr21:33938621 T/A cg09050820 chr6:167586206 TCP10L2 0.83 7.75 0.43 2.01e-13 Gastritis; CESC cis rs796364 0.906 rs281766 chr2:200820505 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.9 9.16 0.49 1.48e-17 Schizophrenia; CESC cis rs727505 1.000 rs56321835 chr7:124529622 T/C cg23710748 chr7:124431027 NA -0.48 -7.5 -0.42 9.75e-13 Lewy body disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11694641 chr12:98987961 SLC25A3 -0.45 -6.55 -0.37 2.89e-10 Gambling; CESC cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg23711669 chr6:146136114 FBXO30 1.01 15.49 0.69 5.86e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs3815700 1.000 rs7248845 chr19:33096718 T/C cg02997394 chr19:33096574 ANKRD27 0.71 7.32 0.41 2.93e-12 Eosinophilic esophagitis; CESC cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg25019033 chr10:957182 NA -0.63 -7.78 -0.43 1.6e-13 Eosinophil percentage of granulocytes; CESC cis rs757110 0.900 rs2074314 chr11:17411821 C/T cg11839944 chr11:17409644 KCNJ11 0.39 5.14 0.3 5.46e-7 Type 2 diabetes; CESC cis rs4588572 0.644 rs9293751 chr5:77778296 A/G cg11547950 chr5:77652471 NA -0.38 -5.44 -0.32 1.23e-7 Triglycerides; CESC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg27170947 chr2:26402098 FAM59B -0.84 -10.03 -0.52 2.88e-20 Gut microbiome composition (summer); CESC cis rs75477785 0.590 rs115503938 chr1:210151419 C/G cg02304930 chr1:210405566 SERTAD4;C1orf133 0.89 6.01 0.35 6.09e-9 Cleft lip with or without cleft palate; CESC cis rs79839061 0.610 rs11248051 chr4:858332 C/T cg07828340 chr4:882639 GAK 1.07 8.29 0.45 5.69e-15 Intelligence (multi-trait analysis); CESC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs1153858 1.000 rs16952714 chr15:45650358 G/A cg14582100 chr15:45693742 SPATA5L1 0.43 6.15 0.35 2.82e-9 Homoarginine levels; CESC cis rs6835098 1.000 rs2332654 chr4:174088399 C/T cg08422745 chr4:174089978 GALNT7 -0.83 -12.26 -0.6 1.16e-27 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs116095464 1.000 rs55671190 chr5:287422 G/A cg22857025 chr5:266934 NA -1.23 -9.26 -0.49 7e-18 Breast cancer; CESC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.51 0.37 3.65e-10 Prudent dietary pattern; CESC trans rs2727020 0.754 rs10839226 chr11:49150883 C/G cg15704280 chr7:45808275 SEPT13 -0.51 -6.07 -0.35 4.36e-9 Coronary artery disease; CESC cis rs8067354 0.507 rs2645478 chr17:58014712 G/A cg02344993 chr17:57696989 CLTC 0.52 5.52 0.32 8.03e-8 Hemoglobin concentration; CESC cis rs12887734 0.524 rs4906364 chr14:104214342 C/G cg01849466 chr14:104193079 ZFYVE21 -0.44 -5.52 -0.32 8.26e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CESC cis rs7116495 0.881 rs1939243 chr11:71742735 A/G cg26138937 chr11:71823887 C11orf51 0.78 6.11 0.35 3.51e-9 Severe influenza A (H1N1) infection; CESC cis rs66573146 0.831 rs1048009 chr4:6988677 G/A cg26116260 chr4:7069785 GRPEL1 -0.73 -5.03 -0.3 9.14e-7 Granulocyte percentage of myeloid white cells; CESC cis rs7772486 0.875 rs2814877 chr6:146299763 C/G cg23711669 chr6:146136114 FBXO30 0.9 13.16 0.63 8.74e-31 Lobe attachment (rater-scored or self-reported); CESC trans rs13035304 0.773 rs7589671 chr2:130507364 T/G cg18827756 chr15:42130735 JMJD7-PLA2G4B;PLA2G4B -0.42 -6.43 -0.37 6.06e-10 Age at smoking initiation in chronic obstructive pulmonary disease; CESC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg21782813 chr7:2030301 MAD1L1 0.41 5.83 0.34 1.58e-8 Bipolar disorder and schizophrenia; CESC cis rs1144333 0.737 rs1144331 chr1:76272357 G/A cg22875332 chr1:76189707 ACADM -0.53 -5.15 -0.3 5.11e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs703842 1.000 rs11172349 chr12:58212528 G/A cg18357645 chr12:58087776 OS9 -0.42 -5.84 -0.34 1.55e-8 Multiple sclerosis; CESC cis rs17253792 0.822 rs74968702 chr14:56076818 A/T cg24579896 chr14:56047964 C14orf33;KTN1 0.77 5.98 0.34 7.23e-9 Putamen volume; CESC cis rs295137 0.752 rs10931892 chr2:201104997 C/T cg23649088 chr2:200775458 C2orf69 -0.43 -5.71 -0.33 2.97e-8 Asthma (bronchodilator response); CESC cis rs4654899 0.929 rs7552999 chr1:21314454 T/C cg05370193 chr1:21551575 ECE1 0.39 5.85 0.34 1.45e-8 Superior frontal gyrus grey matter volume; CESC trans rs11088226 0.681 rs1015048 chr21:33949306 T/C cg09050820 chr6:167586206 TCP10L2 0.94 10.13 0.53 1.36e-20 Gastritis; CESC cis rs8050907 0.744 rs12446765 chr16:4569625 A/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.72 5.2 0.3 3.99e-7 Obesity-related traits; CESC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg21724239 chr8:58056113 NA 0.62 5.77 0.33 2.16e-8 Developmental language disorder (linguistic errors); CESC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg08888203 chr3:10149979 C3orf24 0.46 5.9 0.34 1.11e-8 Alzheimer's disease; CESC cis rs7621025 0.690 rs11715257 chr3:136182053 C/T cg15507776 chr3:136538369 TMEM22 0.44 5.22 0.31 3.56e-7 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CESC cis rs919433 0.783 rs787979 chr2:198242868 A/T cg03934865 chr2:198174659 NA 0.42 6.09 0.35 3.93e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg11764359 chr7:65958608 NA 0.75 9.44 0.5 2.03e-18 Aortic root size; CESC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg09877947 chr5:131593287 PDLIM4 0.4 5.07 0.3 7.56e-7 Blood metabolite levels; CESC cis rs7851660 0.844 rs6478445 chr9:100624299 A/G cg13688889 chr9:100608707 NA -0.64 -8.89 -0.48 9.61e-17 Strep throat; CESC trans rs997295 0.556 rs10468041 chr15:67773203 G/T cg05081167 chr6:156967138 NA 0.27 6.0 0.35 6.31e-9 Motion sickness; CESC cis rs7116495 0.609 rs7121080 chr11:71703935 G/A cg18441811 chr11:71824068 C11orf51 -0.78 -5.3 -0.31 2.43e-7 Severe influenza A (H1N1) infection; CESC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg06558623 chr16:89946397 TCF25 1.17 9.29 0.5 5.84e-18 Skin colour saturation; CESC cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.4 0.41 1.78e-12 Tonsillectomy; CESC cis rs12477438 0.765 rs13406288 chr2:99589585 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -8.74 -0.47 2.81e-16 Chronic sinus infection; CESC cis rs7605827 0.930 rs1125533 chr2:15617751 C/G cg19274914 chr2:15703543 NA 0.35 6.12 0.35 3.29e-9 Educational attainment (years of education); CESC cis rs9902453 0.935 rs9909093 chr17:28271207 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 9.16 0.49 1.49e-17 Coffee consumption (cups per day); CESC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg05535760 chr7:792225 HEATR2 -0.76 -7.99 -0.44 4.17e-14 Cerebrospinal P-tau181p levels; CESC trans rs5003154 0.905 rs13273982 chr8:82001360 C/G cg13159566 chr12:82752887 CCDC59;C12orf26 -0.39 -6.48 -0.37 4.41e-10 Bladder cancer; CESC cis rs6460942 0.591 rs80311633 chr7:12339690 G/C cg02935154 chr7:12443704 VWDE -0.5 -5.25 -0.31 3.07e-7 Coronary artery disease; CESC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.92 9.76 0.51 2.07e-19 Platelet count; CESC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg18758796 chr5:131593413 PDLIM4 -0.42 -5.65 -0.33 4.19e-8 Breast cancer; CESC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg13206674 chr6:150067644 NUP43 0.44 6.42 0.37 6.24e-10 Lung cancer; CESC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.24 -0.41 4.79e-12 Developmental language disorder (linguistic errors); CESC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 5.09 0.3 6.73e-7 Electroencephalogram traits; CESC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg22968622 chr17:43663579 NA 1.28 17.05 0.72 1.63e-44 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1878931 0.501 rs9921169 chr16:3421261 A/T cg22508957 chr16:3507546 NAT15 -0.4 -5.83 -0.34 1.59e-8 Body mass index (adult); CESC cis rs763121 0.853 rs3747172 chr22:39067524 A/G cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC trans rs677673 1.000 rs652325 chr20:10476071 C/T cg16021678 chr13:55475951 NA 0.46 6.09 0.35 3.98e-9 Body mass index (change over time) in chronic obstructive pulmonary disease; CESC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg00802000 chr16:706648 WDR90 -0.4 -6.19 -0.36 2.33e-9 Height; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02056921 chr1:901892 PLEKHN1 0.49 6.3 0.36 1.23e-9 Gut microbiota (bacterial taxa); CESC cis rs9640161 0.789 rs11767409 chr7:150058043 C/T cg27494647 chr7:150038898 RARRES2 0.42 5.12 0.3 5.75e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg03647317 chr4:187891568 NA -0.37 -5.56 -0.32 6.44e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg23711669 chr6:146136114 FBXO30 0.97 14.46 0.66 2.38e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg03396347 chr1:1875803 NA -0.43 -6.67 -0.38 1.46e-10 Body mass index; CESC cis rs2839186 0.872 rs13046834 chr21:47701485 T/C cg10351095 chr21:47802916 PCNT -0.5 -6.8 -0.39 6.74e-11 Testicular germ cell tumor; CESC cis rs11864453 0.826 rs12708928 chr16:72137227 C/A cg01557791 chr16:72042693 DHODH -0.52 -6.78 -0.38 7.81e-11 Fibrinogen levels; CESC cis rs4654899 0.802 rs935918 chr1:21145660 C/T cg05370193 chr1:21551575 ECE1 0.39 5.7 0.33 3.12e-8 Superior frontal gyrus grey matter volume; CESC cis rs7666738 0.830 rs11729753 chr4:98803267 T/A cg24818145 chr4:99064322 C4orf37 0.4 5.18 0.3 4.34e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24833071 chr7:75115655 POM121C 0.6 6.71 0.38 1.18e-10 Gut microbiome composition (summer); CESC cis rs2415984 0.622 rs2415997 chr14:46930446 A/C cg14871534 chr14:47121158 RPL10L -0.34 -5.13 -0.3 5.71e-7 Number of children ever born; CESC cis rs7586879 0.639 rs2384058 chr2:25100328 A/G cg01884057 chr2:25150051 NA 0.36 6.93 0.39 3.12e-11 Body mass index; CESC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg25036284 chr2:26402008 FAM59B -0.6 -6.97 -0.39 2.56e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC trans rs9987353 0.840 rs329994 chr8:9123233 A/G cg24892074 chr4:89444835 PIGY -0.51 -6.32 -0.36 1.11e-9 Recombination measurement; CESC cis rs1707322 0.929 rs785513 chr1:46538320 T/C cg05343316 chr1:45956843 TESK2 -0.45 -5.34 -0.31 1.96e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs76878669 0.561 rs56321771 chr11:66161072 C/T cg18002602 chr11:66138449 SLC29A2 0.39 6.41 0.37 6.45e-10 Educational attainment (years of education); CESC cis rs7264396 0.635 rs6060688 chr20:34516731 C/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.53 -6.44 -0.37 5.64e-10 Total cholesterol levels; CESC cis rs56046484 0.711 rs71397835 chr15:85530771 C/T cg08123816 chr15:85640762 PDE8A -0.46 -5.27 -0.31 2.78e-7 Testicular germ cell tumor; CESC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg25517755 chr10:38738941 LOC399744 -0.49 -6.35 -0.36 9.08e-10 Extrinsic epigenetic age acceleration; CESC cis rs7927592 0.731 rs2156463 chr11:68386311 T/C cg20283391 chr11:68216788 NA -0.44 -5.37 -0.31 1.69e-7 Total body bone mineral density; CESC cis rs13108904 0.935 rs1620928 chr4:1279124 C/T cg16405210 chr4:1374714 KIAA1530 0.44 5.52 0.32 8.05e-8 Obesity-related traits; CESC cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg18527119 chr7:66119851 NA -0.48 -5.19 -0.3 4.15e-7 Aortic root size; CESC cis rs12681366 0.537 rs6999976 chr8:95482422 C/T cg13257157 chr8:95487014 RAD54B 0.44 5.37 0.31 1.69e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs13253111 1.000 rs13253111 chr8:28061974 C/T cg26534493 chr8:28060551 NA -0.62 -10.34 -0.54 2.9e-21 Childhood body mass index; CESC cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg13175981 chr1:150552382 MCL1 0.72 10.72 0.55 1.6400000000000001e-22 Tonsillectomy; CESC cis rs826838 0.967 rs11183622 chr12:38792849 T/C cg26384229 chr12:38710491 ALG10B 0.83 14.61 0.67 7.23e-36 Heart rate; CESC cis rs12477438 0.520 rs36071868 chr2:99737120 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.87 15.18 0.68 6.85e-38 Chronic sinus infection; CESC cis rs7818345 0.967 rs11204039 chr8:19280442 A/C cg11303988 chr8:19266685 CSGALNACT1 0.32 5.75 0.33 2.51e-8 Language performance in older adults (adjusted for episodic memory); CESC cis rs10870270 0.956 rs10870293 chr10:133771413 G/A cg26149184 chr10:133730230 NA 0.37 5.08 0.3 7.04e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 10.52 0.54 7.52e-22 Platelet count; CESC cis rs8044868 0.530 rs8060770 chr16:72155694 C/A cg16558253 chr16:72132732 DHX38 -0.38 -5.9 -0.34 1.1e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs796364 0.806 rs1106400 chr2:201004089 T/C cg23649088 chr2:200775458 C2orf69 -0.58 -5.71 -0.33 3.07e-8 Schizophrenia; CESC cis rs7872515 1.000 rs10992221 chr9:94832043 A/G cg01248375 chr9:94877805 SPTLC1 -0.56 -5.7 -0.33 3.2e-8 Bipolar disorder and schizophrenia; CESC cis rs2228479 0.702 rs11076621 chr16:89837927 A/G cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs116095464 0.558 rs6555055 chr5:226160 A/C cg22496380 chr5:211416 CCDC127 -0.74 -8.78 -0.47 2.06e-16 Breast cancer; CESC cis rs9916302 0.752 rs9901219 chr17:37558369 T/G cg00129232 chr17:37814104 STARD3 0.56 6.5 0.37 3.99e-10 Glomerular filtration rate (creatinine); CESC cis rs6032067 0.929 rs13039083 chr20:43878838 T/A cg10761708 chr20:43804764 PI3 0.44 5.4 0.31 1.5e-7 Blood protein levels; CESC cis rs113835537 0.529 rs17496250 chr11:66270774 C/G cg22134325 chr11:66188745 NPAS4 0.46 7.16 0.4 8.01e-12 Airway imaging phenotypes; CESC trans rs9467711 0.606 rs9393708 chr6:26362643 C/T cg06606381 chr12:133084897 FBRSL1 0.73 7.01 0.4 1.95e-11 Autism spectrum disorder or schizophrenia; CESC cis rs9457247 0.967 rs1794694 chr6:167404751 T/C cg07741184 chr6:167504864 NA 0.28 5.1 0.3 6.54e-7 Crohn's disease; CESC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg24562669 chr7:97807699 LMTK2 0.52 7.69 0.43 2.87e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs13106227 0.550 rs4859674 chr4:77376813 A/G cg20311846 chr4:77356250 SHROOM3 -0.31 -5.67 -0.33 3.65e-8 Eosinophilic esophagitis (pediatric); CESC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg10053473 chr17:62856997 LRRC37A3 -0.72 -7.68 -0.43 3.06e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs8073060 0.614 rs72829932 chr17:34055935 A/G cg19694781 chr19:47549865 TMEM160 0.74 6.72 0.38 1.14e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs2832191 0.692 rs2245734 chr21:30359965 C/T cg08807101 chr21:30365312 RNF160 0.92 14.34 0.66 6.58e-35 Dental caries; CESC cis rs8114671 0.562 rs6088655 chr20:33527838 A/G cg07148914 chr20:33460835 GGT7 0.47 6.18 0.35 2.4e-9 Height; CESC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg27211696 chr2:191398769 TMEM194B -0.53 -8.0 -0.44 3.94e-14 Pulse pressure; CESC cis rs7178572 0.568 rs10152181 chr15:77678346 A/G cg22256960 chr15:77711686 NA -0.54 -6.95 -0.39 2.9e-11 Type 2 diabetes; CESC trans rs11098499 0.722 rs7673476 chr4:120248683 C/T cg25214090 chr10:38739885 LOC399744 0.58 8.09 0.45 2.14e-14 Corneal astigmatism; CESC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg14159672 chr1:205819179 PM20D1 -0.78 -12.41 -0.61 3.57e-28 Menarche (age at onset); CESC cis rs8072100 0.902 rs12051716 chr17:45582395 G/A cg08085267 chr17:45401833 C17orf57 0.42 5.6 0.33 5.46e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg07701084 chr6:150067640 NUP43 0.43 6.0 0.35 6.52e-9 Lung cancer; CESC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg20151795 chr6:28129481 ZNF389 0.4 5.44 0.32 1.22e-7 Depression; CESC cis rs4319547 1.000 rs7307735 chr12:123087442 A/G cg05707623 chr12:122985044 ZCCHC8 -0.57 -6.82 -0.39 6.15e-11 Body mass index; CESC cis rs7412746 0.634 rs12562939 chr1:150951452 A/C cg04414720 chr1:150670196 GOLPH3L 0.49 6.45 0.37 5.22e-10 Melanoma; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg24508409 chr1:112298175 DDX20;C1orf183 0.5 6.0 0.35 6.63e-9 Psoriatic arthritis; CESC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg18876405 chr7:65276391 NA -0.49 -6.77 -0.38 8.35e-11 Aortic root size; CESC cis rs7267979 0.966 rs2261795 chr20:25263136 T/C cg08601574 chr20:25228251 PYGB 0.39 5.67 0.33 3.69e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs9527 0.590 rs1935323 chr10:104877035 T/C cg04362960 chr10:104952993 NT5C2 0.42 5.28 0.31 2.71e-7 Arsenic metabolism; CESC cis rs1775715 0.707 rs2799024 chr10:32166922 A/G cg18675610 chr10:32216311 ARHGAP12 0.35 5.41 0.32 1.38e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg18016565 chr1:150552671 MCL1 0.33 5.09 0.3 6.65e-7 Tonsillectomy; CESC trans rs35110281 0.840 rs2838331 chr21:45026728 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.54 -7.18 -0.4 7e-12 Mean corpuscular volume; CESC cis rs3008870 1.000 rs2985818 chr1:67398916 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs7193541 0.684 rs9923145 chr16:74686166 G/A cg05580060 chr16:74700937 RFWD3 -0.49 -6.3 -0.36 1.26e-9 Multiple myeloma; CESC cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg12386194 chr3:101231763 SENP7 0.44 5.38 0.31 1.63e-7 Colorectal cancer; CESC cis rs7296418 0.630 rs28419092 chr12:123812629 G/C cg05973401 chr12:123451056 ABCB9 0.42 5.35 0.31 1.91e-7 Platelet count; CESC cis rs6500602 0.701 rs4786500 chr16:4525265 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.38 -5.59 -0.32 5.59e-8 Schizophrenia; CESC cis rs2070488 0.775 rs6780349 chr3:38555178 C/T cg24069376 chr3:38537580 EXOG -0.32 -5.55 -0.32 7.02e-8 Electrocardiographic conduction measures; CESC cis rs897984 0.609 rs4889609 chr16:31026427 A/G cg02466173 chr16:30829666 NA -0.38 -6.48 -0.37 4.36e-10 Dementia with Lewy bodies; CESC cis rs11249608 0.548 rs13161528 chr5:178452958 C/G cg01312482 chr5:178451176 ZNF879 -0.46 -6.48 -0.37 4.52e-10 Pubertal anthropometrics; CESC cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg18198730 chr1:247681584 NA 0.59 7.76 0.43 1.84e-13 Acute lymphoblastic leukemia (childhood); CESC cis rs9300255 0.602 rs2851438 chr12:123643689 T/C cg05973401 chr12:123451056 ABCB9 0.5 5.81 0.34 1.79e-8 Neutrophil percentage of white cells; CESC cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg11752832 chr7:134001865 SLC35B4 0.54 7.09 0.4 1.18e-11 Mean platelet volume; CESC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg17724175 chr1:150552817 MCL1 0.33 5.13 0.3 5.51e-7 Melanoma; CESC cis rs1270639 0.778 rs2906934 chr7:157451447 G/A cg13357408 chr7:157437802 PTPRN2 0.61 6.72 0.38 1.12e-10 Colorectal cancer; CESC cis rs6547741 1.000 rs1528402 chr2:27857517 G/A cg27432699 chr2:27873401 GPN1 0.46 6.43 0.37 5.87e-10 Oral cavity cancer; CESC cis rs9487051 0.714 rs6902892 chr6:109627601 G/T cg21918786 chr6:109611834 NA -0.36 -5.29 -0.31 2.52e-7 Reticulocyte fraction of red cells; CESC cis rs2840044 0.534 rs321596 chr17:33885736 C/T cg05299278 chr17:33885742 SLFN14 -0.44 -6.32 -0.36 1.08e-9 Response to radiotherapy in cancer (late toxicity); CESC cis rs9611565 0.512 rs4822052 chr22:42193741 G/A cg06634786 chr22:41940651 POLR3H -0.68 -6.91 -0.39 3.6e-11 Vitiligo; CESC cis rs8062405 1.000 rs12443881 chr16:28841777 C/T cg05966235 chr16:28915196 ATP2A1 0.34 5.13 0.3 5.71e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg03433033 chr1:76189801 ACADM 0.57 5.63 0.33 4.7e-8 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2294693 0.945 rs68031000 chr6:41008841 G/T cg14769373 chr6:40998127 UNC5CL -0.45 -5.78 -0.33 2.09e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs858239 0.600 rs10233039 chr7:23143113 G/A cg23682824 chr7:23144976 KLHL7 0.51 6.86 0.39 4.76e-11 Cerebrospinal fluid biomarker levels; CESC cis rs8058578 1.000 rs2289442 chr16:30739919 A/G cg00531865 chr16:30841666 NA -0.41 -5.37 -0.31 1.76e-7 Multiple myeloma; CESC cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg12365402 chr11:9010492 NRIP3 0.49 8.24 0.45 8.06e-15 Hemoglobin concentration; CESC cis rs6582630 0.622 rs11831595 chr12:38511489 C/A cg26384229 chr12:38710491 ALG10B -0.43 -5.78 -0.33 2.12e-8 Drug-induced liver injury (flucloxacillin); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06756931 chr17:78820893 RPTOR 0.49 6.95 0.39 2.79e-11 Fibrinogen levels; CESC cis rs3806843 0.933 rs10069930 chr5:140163328 T/A cg26395211 chr5:140044315 WDR55 -0.41 -5.3 -0.31 2.39e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.59 0.32 5.58e-8 Bipolar disorder; CESC cis rs7264396 1.000 rs224409 chr20:34124920 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -6.47 -0.37 4.78e-10 Total cholesterol levels; CESC cis rs3806843 1.000 rs6898939 chr5:140169355 C/A cg26395211 chr5:140044315 WDR55 -0.42 -5.3 -0.31 2.39e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1348850 0.750 rs12997716 chr2:178494629 G/A cg22681709 chr2:178499509 PDE11A -0.43 -6.47 -0.37 4.78e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02958167 chr6:170151846 TCTE3;C6orf70 0.61 7.18 0.4 7.13e-12 Gut microbiome composition (summer); CESC cis rs1348850 0.668 rs6734683 chr2:178494012 C/G cg23306229 chr2:178417860 TTC30B 0.56 6.75 0.38 9.5e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04297258 chr16:88772664 RNF166;CTU2 -0.48 -6.9 -0.39 3.74e-11 Gambling; CESC cis rs1344694 0.566 rs4672790 chr2:216892446 C/T cg12620499 chr2:216877984 MREG 0.65 9.63 0.51 5.12e-19 Alcohol dependence; CESC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg27170947 chr2:26402098 FAM59B -0.65 -7.94 -0.44 5.66e-14 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 6.18e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9430161 0.564 rs12081176 chr1:11034145 T/C cg02454025 chr1:11042201 C1orf127 0.99 16.1 0.7 3.84e-41 Ewing sarcoma; CESC cis rs9549367 0.713 rs3024769 chr13:113825601 A/C cg00898013 chr13:113819073 PROZ 0.46 6.7 0.38 1.25e-10 Platelet distribution width; CESC cis rs870825 0.616 rs79884757 chr4:185621454 A/G cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg11764359 chr7:65958608 NA 0.88 13.78 0.65 5.87e-33 Aortic root size; CESC cis rs9902453 0.934 rs8079028 chr17:28484234 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.43 0.46 2.29e-15 Coffee consumption (cups per day); CESC cis rs9296095 0.747 rs12206050 chr6:33564296 A/T cg14003231 chr6:33640908 ITPR3 0.43 6.59 0.37 2.43e-10 Platelet count; CESC trans rs561341 0.941 rs501773 chr17:30314435 T/G cg20587970 chr11:113659929 NA -1.1 -13.93 -0.65 1.88e-33 Hip circumference adjusted for BMI; CESC cis rs9388451 0.839 rs3757217 chr6:126069636 G/C cg10911889 chr6:126070802 HEY2 0.41 5.67 0.33 3.64e-8 Brugada syndrome; CESC cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg00033643 chr7:134001901 SLC35B4 0.41 5.13 0.3 5.72e-7 Mean platelet volume; CESC cis rs7561273 0.586 rs116650625 chr2:24353212 C/G cg20701182 chr2:24300061 SF3B14 0.46 6.01 0.35 6.27e-9 Quantitative traits; CESC cis rs950776 0.518 rs2869544 chr15:78839400 G/A cg24631222 chr15:78858424 CHRNA5 0.39 5.12 0.3 5.79e-7 Sudden cardiac arrest; CESC cis rs763121 0.853 rs6001214 chr22:39149155 C/T cg06544989 chr22:39130855 UNC84B 0.49 8.7 0.47 3.68e-16 Menopause (age at onset); CESC cis rs12900413 0.603 rs7177841 chr15:90302117 C/A cg24249390 chr15:90295951 MESP1 -0.4 -5.4 -0.31 1.52e-7 Coronary artery aneurysm in Kawasaki disease; CESC cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg24296786 chr1:45957014 TESK2 0.68 9.37 0.5 3.33e-18 High light scatter reticulocyte count; CESC cis rs6484504 0.512 rs7940020 chr11:31366453 T/G cg14844989 chr11:31128820 NA 0.38 5.16 0.3 4.92e-7 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27367768 chr5:171615456 STK10 0.52 6.0 0.35 6.47e-9 Gut microbiome composition (summer); CESC cis rs644799 1.000 rs586498 chr11:95537828 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.38 0.37 7.71e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -5.07 -0.3 7.39e-7 Cognitive function; CESC cis rs4409675 0.576 rs7520860 chr1:28232952 C/A cg23691781 chr1:28212827 C1orf38 0.28 5.53 0.32 7.57e-8 Corneal astigmatism; CESC cis rs6964587 0.967 rs34574955 chr7:91847550 A/C cg17063962 chr7:91808500 NA 0.58 7.86 0.43 9.59e-14 Breast cancer; CESC cis rs262150 0.819 rs6956589 chr7:158769301 C/T cg19418458 chr7:158789849 NA -0.5 -7.97 -0.44 4.62e-14 Facial morphology (factor 20); CESC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg13393036 chr8:95962371 TP53INP1 -0.49 -10.71 -0.55 1.77e-22 Type 2 diabetes; CESC trans rs12960505 0.506 rs1125627 chr18:51004270 C/T cg16503797 chr18:19476805 NA 0.42 6.11 0.35 3.54e-9 Intelligence (multi-trait analysis); CESC cis rs7408868 0.520 rs1043994 chr19:15302844 T/C cg14696996 chr19:15285081 NOTCH3 0.96 9.33 0.5 4.33e-18 Pulse pressure; CESC cis rs922182 0.542 rs7179912 chr15:64263854 C/T cg24729988 chr15:64271149 DAPK2 0.4 5.32 0.31 2.21e-7 Blood protein levels; CESC cis rs2073300 1.000 rs6132622 chr20:23442240 A/T cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7824557 0.628 rs34237267 chr8:11197301 G/C cg21775007 chr8:11205619 TDH 0.58 9.28 0.5 6.25e-18 Retinal vascular caliber; CESC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg05564831 chr3:52568323 NT5DC2 0.45 6.9 0.39 3.76e-11 Bipolar disorder; CESC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg09365446 chr1:150670422 GOLPH3L 0.42 5.84 0.34 1.55e-8 Tonsillectomy; CESC cis rs2645694 0.626 rs2703122 chr4:77821418 A/C cg18351406 chr4:77819688 ANKRD56 0.55 6.89 0.39 4.12e-11 Emphysema distribution in smoking; CESC cis rs7267979 1.000 rs2424716 chr20:25423538 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.83 16.43 0.71 2.68e-42 Liver enzyme levels (alkaline phosphatase); CESC cis rs826838 0.967 rs1719852 chr12:39128531 A/G cg26384229 chr12:38710491 ALG10B -0.66 -10.31 -0.54 3.42e-21 Heart rate; CESC cis rs2228479 0.541 rs12918575 chr16:89811151 A/G cg00800038 chr16:89945340 TCF25 -0.71 -7.24 -0.41 4.76e-12 Skin colour saturation; CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg23034840 chr1:205782522 SLC41A1 0.68 8.34 0.46 4.1e-15 Menarche (age at onset); CESC cis rs9399135 0.935 rs2150680 chr6:135347131 G/C cg22676075 chr6:135203613 NA 0.51 7.36 0.41 2.34e-12 Red blood cell count; CESC cis rs9788682 0.706 rs2568493 chr15:78740233 G/A cg24631222 chr15:78858424 CHRNA5 -0.61 -7.19 -0.4 6.65e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 4.04e-7 Colonoscopy-negative controls vs population controls; CESC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg12463550 chr7:65579703 CRCP 0.59 7.42 0.41 1.55e-12 Aortic root size; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg06124975 chr6:107810578 SOBP 0.46 6.11 0.35 3.52e-9 Gut microbiota (bacterial taxa); CESC cis rs10779751 0.734 rs1034528 chr1:11249132 G/C cg08854313 chr1:11322531 MTOR -0.82 -10.73 -0.55 1.5e-22 Body mass index; CESC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.61 -0.33 5.09e-8 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13253694 chr11:60609608 CCDC86 0.56 6.39 0.37 7.59e-10 Gut microbiome composition (summer); CESC cis rs1670533 1.000 rs633556 chr4:1092405 A/G cg27284194 chr4:1044797 NA 0.45 5.84 0.34 1.5e-8 Recombination rate (females); CESC cis rs2066819 1.000 rs1274493 chr12:56682371 C/T cg26714650 chr12:56694279 CS 1.29 16.3 0.71 7.7e-42 Psoriasis vulgaris; CESC cis rs9916302 0.861 rs4795376 chr17:37669043 T/C cg07936489 chr17:37558343 FBXL20 -0.8 -11.82 -0.59 3.49e-26 Glomerular filtration rate (creatinine); CESC cis rs7267979 1.000 rs6138575 chr20:25438952 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.34 0.69 1.94e-38 Liver enzyme levels (alkaline phosphatase); CESC cis rs10791097 0.694 rs4937581 chr11:130740335 T/C cg12179176 chr11:130786555 SNX19 0.64 10.04 0.52 2.69e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg07701084 chr6:150067640 NUP43 0.43 6.0 0.35 6.52e-9 Lung cancer; CESC cis rs7937682 0.924 rs4630327 chr11:111539327 C/T cg22437258 chr11:111473054 SIK2 -0.67 -9.17 -0.49 1.34e-17 Primary sclerosing cholangitis; CESC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg02725872 chr8:58115012 NA -0.42 -5.88 -0.34 1.25e-8 Developmental language disorder (linguistic errors); CESC cis rs2735413 0.875 rs12924402 chr16:78083477 C/G cg04733911 chr16:78082701 NA -0.53 -8.86 -0.48 1.17e-16 Systolic blood pressure (alcohol consumption interaction); CESC cis rs12142240 0.698 rs17361950 chr1:46864150 C/T cg00530320 chr1:46809349 NSUN4 0.59 7.98 0.44 4.57e-14 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13446525 chr9:128170432 NA 0.56 7.16 0.4 8.09e-12 Gut microbiome composition (summer); CESC cis rs61931739 0.517 rs12367881 chr12:34175508 T/C cg19457237 chr12:34500585 NA -0.4 -5.33 -0.31 2.11e-7 Morning vs. evening chronotype; CESC cis rs67311347 1.000 rs73078163 chr3:40479958 C/T cg09455208 chr3:40491958 NA 0.51 8.35 0.46 3.82e-15 Renal cell carcinoma; CESC cis rs7680126 0.633 rs11730631 chr4:10292968 C/T cg00071950 chr4:10020882 SLC2A9 0.51 5.82 0.34 1.66e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs10870270 1.000 rs3935905 chr10:133758262 A/C cg26149184 chr10:133730230 NA 0.38 5.2 0.3 4.06e-7 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC trans rs7618501 1.000 rs7374183 chr3:49785133 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -8.49 -0.46 1.52e-15 Intelligence (multi-trait analysis); CESC cis rs854765 0.693 rs11657074 chr17:17770355 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.45 -5.83 -0.34 1.58e-8 Total body bone mineral density; CESC cis rs11122272 0.735 rs2246645 chr1:231497393 T/G cg06096015 chr1:231504339 EGLN1 0.44 6.42 0.37 6.34e-10 Hemoglobin concentration; CESC cis rs42648 0.869 rs1015404 chr7:89913946 G/C cg23697855 chr7:89950296 NA 0.27 5.05 0.3 8.24e-7 Homocysteine levels; CESC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.69 0.33 3.3e-8 Personality dimensions; CESC cis rs4268898 0.931 rs2551121 chr2:24539967 T/C cg20701182 chr2:24300061 SF3B14 0.49 5.9 0.34 1.1e-8 Asthma; CESC cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -6.96 -0.39 2.69e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg21144161 chr5:423903 AHRR 0.37 5.98 0.34 7.12e-9 Cystic fibrosis severity; CESC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg13798912 chr7:905769 UNC84A -0.56 -5.53 -0.32 7.82e-8 Cerebrospinal P-tau181p levels; CESC cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg08109568 chr15:31115862 NA -0.71 -9.43 -0.5 2.19e-18 Huntington's disease progression; CESC cis rs1483890 0.723 rs2007578 chr3:69408982 T/A cg22125112 chr3:69402811 FRMD4B 0.41 5.53 0.32 7.56e-8 Resting heart rate; CESC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.57 6.53 0.37 3.36e-10 Menopause (age at onset); CESC cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg02487422 chr3:49467188 NICN1 0.43 5.52 0.32 7.91e-8 Parkinson's disease; CESC cis rs2486288 0.656 rs12911186 chr15:45551423 A/G cg21132104 chr15:45694354 SPATA5L1 -0.54 -6.55 -0.37 3.03e-10 Glomerular filtration rate; CESC cis rs7818345 0.935 rs4633071 chr8:19275852 G/A cg11303988 chr8:19266685 CSGALNACT1 0.34 6.25 0.36 1.64e-9 Language performance in older adults (adjusted for episodic memory); CESC cis rs71403859 0.502 rs35394108 chr16:71540639 T/C cg08717414 chr16:71523259 ZNF19 -1.02 -9.82 -0.52 1.29e-19 Post bronchodilator FEV1; CESC cis rs2463822 0.920 rs11828383 chr11:62067818 C/T cg06239285 chr11:62104954 ASRGL1 -1.08 -9.44 -0.5 2.08e-18 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg01988459 chr11:68622903 NA -0.45 -6.33 -0.36 1.02e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg21394442 chr8:110346440 ENY2;NUDCD1 -0.47 -6.54 -0.37 3.09e-10 Gut microbiota (bacterial taxa); CESC cis rs2832191 0.716 rs1543652 chr21:30448000 G/C cg08807101 chr21:30365312 RNF160 0.93 14.2 0.66 2.05e-34 Dental caries; CESC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg24531977 chr5:56204891 C5orf35 -0.59 -7.73 -0.43 2.2e-13 Coronary artery disease; CESC cis rs9611565 0.649 rs5758434 chr22:42116163 G/A cg06481639 chr22:41940642 POLR3H 0.48 5.58 0.32 6.02e-8 Vitiligo; CESC cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg00033643 chr7:134001901 SLC35B4 0.41 5.15 0.3 5.13e-7 Mean platelet volume; CESC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg05368731 chr17:41323189 NBR1 0.8 11.27 0.57 2.51e-24 Menopause (age at onset); CESC cis rs2832191 0.791 rs2832178 chr21:30479858 T/G cg24692254 chr21:30365293 RNF160 -0.8 -12.76 -0.62 2.24e-29 Dental caries; CESC cis rs6772849 0.896 rs35535737 chr3:128383406 G/A cg16766828 chr3:128327626 NA -0.31 -5.12 -0.3 5.93e-7 Monocyte percentage of white cells;Monocyte count; CESC cis rs7528419 1.000 rs629301 chr1:109818306 G/T cg00908766 chr1:109817496 CELSR2 0.5 7.35 0.41 2.49e-12 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CESC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg05872129 chr22:39784769 NA -0.81 -10.75 -0.55 1.29e-22 Intelligence (multi-trait analysis); CESC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC cis rs1577917 0.876 rs66986937 chr6:86532191 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.51 -6.61 -0.38 2.11e-10 Response to antipsychotic treatment; CESC cis rs921968 0.565 rs6436069 chr2:219597185 T/C cg02176678 chr2:219576539 TTLL4 -0.44 -7.76 -0.43 1.79e-13 Mean corpuscular hemoglobin concentration; CESC cis rs9837602 0.872 rs34996634 chr3:99738219 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.47 6.07 0.35 4.47e-9 Breast cancer; CESC cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg18016565 chr1:150552671 MCL1 -0.32 -5.3 -0.31 2.46e-7 Tonsillectomy; CESC cis rs863345 0.604 rs12034004 chr1:158463885 A/G cg12129480 chr1:158549410 OR10X1 -0.35 -6.97 -0.39 2.46e-11 Pneumococcal bacteremia; CESC cis rs5167 0.789 rs204467 chr19:45491174 A/G cg09555818 chr19:45449301 APOC2 -0.35 -5.06 -0.3 7.67e-7 Blood protein levels; CESC cis rs6537837 0.838 rs3737182 chr1:110091271 C/T cg05049280 chr1:110155535 GNAT2 0.4 5.63 0.33 4.68e-8 Major depressive disorder; CESC cis rs7429990 0.932 rs6442101 chr3:48130893 C/T cg11946769 chr3:48343235 NME6 -0.54 -6.59 -0.38 2.42e-10 Educational attainment (years of education); CESC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg11663144 chr21:46675770 NA -0.5 -7.64 -0.43 3.86e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs11785400 0.793 rs1137521 chr8:143739162 C/T cg24634471 chr8:143751801 JRK 0.45 5.69 0.33 3.29e-8 Schizophrenia; CESC cis rs7917772 0.582 rs4408249 chr10:104374653 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.39 5.33 0.31 2.11e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs9910055 0.530 rs11656758 chr17:42301541 A/G cg13607699 chr17:42295918 UBTF 0.82 12.63 0.61 6.1e-29 Total body bone mineral density; CESC cis rs854765 0.505 rs2955358 chr17:17946623 A/G cg16928487 chr17:17741425 SREBF1 0.57 9.81 0.52 1.36e-19 Total body bone mineral density; CESC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg08027265 chr7:2291960 NA -0.38 -5.51 -0.32 8.31e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs11098499 0.954 rs4577559 chr4:120404043 T/G cg09307838 chr4:120376055 NA 0.93 13.07 0.63 1.78e-30 Corneal astigmatism; CESC cis rs1790761 0.554 rs3758938 chr11:67402362 T/G cg24690094 chr11:67383802 NA -0.35 -5.48 -0.32 9.74e-8 Mean corpuscular volume; CESC cis rs3741151 0.764 rs73548680 chr11:73271335 T/C cg17517138 chr11:73019481 ARHGEF17 1.03 7.61 0.42 4.75e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs933688 1.000 rs332531 chr5:90790451 G/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.95 11.97 0.59 1.1e-26 Smoking behavior; CESC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg06456125 chr7:65229604 NA 0.4 5.23 0.31 3.51e-7 Aortic root size; CESC cis rs11190604 1.000 rs11190592 chr10:102291059 T/C cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg26240433 chr14:94547826 DDX24;IFI27L1 -0.43 -6.11 -0.35 3.51e-9 Gut microbiota (bacterial taxa); CESC cis rs12410462 1.000 rs1587158 chr1:227658753 G/A cg23173402 chr1:227635558 NA -0.56 -5.75 -0.33 2.44e-8 Major depressive disorder; CESC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg24829409 chr8:58192753 C8orf71 -0.67 -8.02 -0.44 3.52e-14 Developmental language disorder (linguistic errors); CESC cis rs9818758 0.607 rs9990153 chr3:49291883 C/T cg00383909 chr3:49044727 WDR6 0.73 6.32 0.36 1.1e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC trans rs7666738 0.830 rs4292341 chr4:98959724 C/T cg01369341 chr16:4852941 ROGDI 0.44 6.1 0.35 3.77e-9 Colonoscopy-negative controls vs population controls; CESC cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg20476274 chr7:133979776 SLC35B4 0.68 10.15 0.53 1.19e-20 Mean platelet volume; CESC cis rs9303401 0.614 rs34920953 chr17:56589406 G/A cg10487724 chr17:56770010 TEX14;RAD51C 1.0 12.26 0.6 1.16e-27 Cognitive test performance; CESC trans rs875971 1.000 rs6961990 chr7:65888570 C/A cg26939375 chr7:64535504 NA 0.47 6.04 0.35 5.14e-9 Aortic root size; CESC cis rs7683537 0.887 rs7678412 chr4:185648611 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Systemic lupus erythematosus; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03503634 chr11:36531973 TRAF6 -0.55 -7.61 -0.42 4.95e-13 Fibrinogen levels; CESC cis rs1270639 0.778 rs2906928 chr7:157444976 T/G cg13357408 chr7:157437802 PTPRN2 0.62 7.26 0.41 4.32e-12 Colorectal cancer; CESC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs7134594 0.677 rs7137190 chr12:109866108 G/C cg19025524 chr12:109796872 NA -0.41 -5.92 -0.34 9.73e-9 HDL cholesterol; CESC cis rs9911578 1.000 rs9897326 chr17:56902297 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.26 0.31 3.04e-7 Intelligence (multi-trait analysis); CESC cis rs4253772 0.638 rs6007845 chr22:46718417 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.73 -9.0 -0.48 4.53e-17 LDL cholesterol;Cholesterol, total; CESC cis rs4803468 1.000 rs3810174 chr19:41904165 C/T cg09537434 chr19:41945824 ATP5SL -1.02 -18.28 -0.75 7.49e-49 Height; CESC cis rs8067354 0.681 rs76856339 chr17:57800966 G/A cg13753209 chr17:57696993 CLTC 0.59 6.34 0.36 9.87e-10 Hemoglobin concentration; CESC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg18404041 chr3:52824283 ITIH1 -0.45 -7.4 -0.41 1.84e-12 Bipolar disorder; CESC cis rs7084402 0.967 rs1658429 chr10:60330422 T/C cg07615347 chr10:60278583 BICC1 0.59 9.15 0.49 1.57e-17 Refractive error; CESC cis rs10751667 0.961 rs6597953 chr11:991099 G/A cg20946044 chr11:1010712 AP2A2 -0.46 -5.89 -0.34 1.17e-8 Alzheimer's disease (late onset); CESC cis rs561341 1.000 rs8070262 chr17:30262467 A/G cg12193833 chr17:30244370 NA -0.49 -5.49 -0.32 9.5e-8 Hip circumference adjusted for BMI; CESC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg11494091 chr17:61959527 GH2 0.72 12.38 0.61 4.46e-28 Prudent dietary pattern; CESC cis rs6963495 0.538 rs55967123 chr7:105163678 C/A cg19920283 chr7:105172520 RINT1 0.7 6.66 0.38 1.58e-10 Bipolar disorder (body mass index interaction); CESC cis rs7666738 0.830 rs4699577 chr4:98846513 G/A cg05340658 chr4:99064831 C4orf37 0.71 10.13 0.53 1.37e-20 Colonoscopy-negative controls vs population controls; CESC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg15556689 chr8:8085844 FLJ10661 -0.44 -5.58 -0.32 5.8e-8 Mood instability; CESC cis rs212524 0.544 rs6665399 chr1:21553933 T/C cg05370193 chr1:21551575 ECE1 0.41 6.43 0.37 5.82e-10 Height; CESC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg22920501 chr2:26401640 FAM59B 0.68 7.89 0.44 8.2e-14 Gut microbiome composition (summer); CESC trans rs11722228 0.549 rs73212863 chr4:10104173 C/T cg26043149 chr18:55253948 FECH 0.92 10.72 0.55 1.62e-22 Gout;Urate levels;Serum uric acid levels; CESC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg18404041 chr3:52824283 ITIH1 -0.49 -8.04 -0.44 2.93e-14 Bipolar disorder; CESC cis rs5753037 0.702 rs36576 chr22:30206291 C/A cg01021169 chr22:30184971 ASCC2 -0.46 -6.5 -0.37 3.97e-10 Type 1 diabetes; CESC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg07677032 chr17:61819896 STRADA 0.46 6.1 0.35 3.83e-9 Prudent dietary pattern; CESC cis rs738322 0.839 rs2413505 chr22:38592967 G/A cg17652424 chr22:38574118 PLA2G6 0.3 5.23 0.31 3.43e-7 Cutaneous nevi; CESC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg25405998 chr7:65216604 CCT6P1 -0.5 -5.28 -0.31 2.64e-7 Aortic root size; CESC trans rs9354308 0.899 rs2802055 chr6:66545756 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.59 6.53 0.37 3.39e-10 Metabolite levels; CESC cis rs12995491 0.933 rs7590305 chr2:88513131 C/T cg04511125 chr2:88470314 THNSL2 -0.5 -6.99 -0.39 2.27e-11 Response to metformin (IC50); CESC trans rs9929218 0.953 rs3118235 chr16:68732977 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.7 8.79 0.48 1.86e-16 Colorectal cancer; CESC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.82 0.65 4.25e-33 Prudent dietary pattern; CESC cis rs9611565 0.765 rs132905 chr22:41799106 C/A cg06481639 chr22:41940642 POLR3H 0.62 6.57 0.37 2.65e-10 Vitiligo; CESC cis rs9858542 0.953 rs6446264 chr3:49417243 C/A cg03060546 chr3:49711283 APEH -0.53 -6.04 -0.35 5.23e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs7617773 0.817 rs9830016 chr3:48282494 A/G cg11946769 chr3:48343235 NME6 0.79 11.36 0.57 1.28e-24 Coronary artery disease; CESC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.39 5.86 0.34 1.41e-8 Cystic fibrosis severity; CESC cis rs113835537 0.559 rs11227497 chr11:66269464 T/C cg22134325 chr11:66188745 NPAS4 0.35 5.59 0.32 5.77e-8 Airway imaging phenotypes; CESC cis rs9814567 1.000 rs9813774 chr3:134227100 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.76 -0.33 2.38e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC trans rs7980799 0.653 rs11052722 chr12:33626530 G/A cg26384229 chr12:38710491 ALG10B -0.51 -7.06 -0.4 1.47e-11 Heart rate;Heart rate variability traits (RMSSD); CESC trans rs7980799 0.682 rs7303356 chr12:33633599 C/G cg26384229 chr12:38710491 ALG10B -0.53 -7.33 -0.41 2.83e-12 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs7527798 0.592 rs2296159 chr1:207851760 G/A cg21110645 chr1:207815933 NA -0.33 -5.76 -0.33 2.39e-8 Erythrocyte sedimentation rate; CESC cis rs7336332 0.598 rs12018313 chr13:28012266 C/A cg22138327 chr13:27999177 GTF3A 0.62 5.82 0.34 1.71e-8 Weight; CESC trans rs748404 0.578 rs573615 chr15:43614281 C/T cg24053811 chr14:70265306 SLC10A1 0.41 6.0 0.35 6.61e-9 Lung cancer; CESC cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg05347473 chr6:146136440 FBXO30 0.55 7.08 0.4 1.31e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg24829409 chr8:58192753 C8orf71 -0.67 -8.14 -0.45 1.54e-14 Developmental language disorder (linguistic errors); CESC cis rs17608059 0.679 rs9898056 chr17:13951966 C/G cg11395062 chr17:14139857 CDRT15 0.48 6.28 0.36 1.38e-9 Temperament; CESC cis rs977987 0.843 rs11149824 chr16:75431830 C/G cg03315344 chr16:75512273 CHST6 0.4 5.71 0.33 3e-8 Dupuytren's disease; CESC cis rs72781680 0.593 rs72797817 chr2:24350569 A/G cg08917208 chr2:24149416 ATAD2B 0.55 5.36 0.31 1.79e-7 Lymphocyte counts; CESC cis rs13095912 0.785 rs6807927 chr3:185324933 A/G cg11274856 chr3:185301563 NA -0.37 -5.68 -0.33 3.5e-8 Systolic blood pressure; CESC cis rs2708240 0.967 rs2710098 chr7:147574672 G/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.35 -5.77 -0.33 2.23e-8 QT interval (drug interaction); CESC cis rs6433857 0.594 rs11680811 chr2:181519898 A/G cg23363182 chr2:181467187 NA -0.46 -6.24 -0.36 1.69e-9 Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20300707 chr1:1162156 SDF4 0.44 6.2 0.36 2.16e-9 Fibrinogen levels; CESC cis rs7584330 0.784 rs1463795 chr2:238412392 C/G cg14458575 chr2:238380390 NA -0.52 -7.35 -0.41 2.51e-12 Prostate cancer; CESC cis rs1670533 1.000 rs11725984 chr4:1087338 C/T cg04106633 chr4:1044584 NA 0.4 5.08 0.3 6.98e-7 Recombination rate (females); CESC cis rs3768617 0.727 rs12066735 chr1:183101451 T/G ch.1.3577855R chr1:183094577 LAMC1 0.66 9.16 0.49 1.45e-17 Fuchs's corneal dystrophy; CESC cis rs7301826 0.610 rs36051740 chr12:131292722 G/A cg11011512 chr12:131303247 STX2 -0.49 -5.94 -0.34 8.85e-9 Plasma plasminogen activator levels; CESC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg18765753 chr7:1198926 ZFAND2A -0.46 -5.71 -0.33 3.07e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9815354 0.767 rs73079350 chr3:41876310 C/T cg03022575 chr3:42003672 ULK4 0.71 6.23 0.36 1.84e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7216064 1.000 rs8074078 chr17:65838743 A/C cg12091567 chr17:66097778 LOC651250 -0.8 -9.08 -0.49 2.62e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs7666738 0.822 rs9992360 chr4:98937123 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.56 0.47 9.36e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6500395 0.963 rs2111242 chr16:48708300 T/C cg04672837 chr16:48644449 N4BP1 -0.51 -6.53 -0.37 3.33e-10 Response to tocilizumab in rheumatoid arthritis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03142411 chr4:3375410 RGS12 0.49 6.67 0.38 1.45e-10 Fibrinogen levels; CESC cis rs5753037 0.653 rs140131 chr22:30151716 A/G cg01021169 chr22:30184971 ASCC2 -0.43 -6.11 -0.35 3.47e-9 Type 1 diabetes; CESC cis rs2637266 0.765 rs2438993 chr10:78414604 A/C cg18941641 chr10:78392320 NA 0.41 7.62 0.42 4.43e-13 Pulmonary function; CESC cis rs2456568 0.867 rs72962810 chr11:93663619 A/G cg26875233 chr11:93583750 C11orf90 -0.29 -5.14 -0.3 5.28e-7 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg26314531 chr2:26401878 FAM59B -0.6 -6.84 -0.39 5.32e-11 Gut microbiome composition (summer); CESC cis rs2637266 0.777 rs1907302 chr10:78310828 T/C cg18941641 chr10:78392320 NA 0.31 5.47 0.32 1.03e-7 Pulmonary function; CESC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg07507251 chr3:52567010 NT5DC2 0.43 7.4 0.41 1.84e-12 Bipolar disorder; CESC cis rs7916697 0.626 rs3858144 chr10:70011354 A/G cg06988349 chr10:69991859 ATOH7 0.31 5.23 0.31 3.43e-7 Optic disc area; CESC cis rs7847628 0.587 rs10760117 chr9:123586737 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.82 13.32 0.63 2.43e-31 Birth weight; CESC cis rs7914558 1.000 rs10883824 chr10:104812897 A/G cg15744005 chr10:104629667 AS3MT -0.34 -5.58 -0.32 5.99e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs12318506 0.623 rs12313311 chr12:75768327 A/T cg04728562 chr12:75699417 CAPS2 -1.13 -7.76 -0.43 1.82e-13 Coronary artery calcification; CESC cis rs7116495 0.609 rs10501408 chr11:71680590 C/T cg18441811 chr11:71824068 C11orf51 -0.86 -5.06 -0.3 7.97e-7 Severe influenza A (H1N1) infection; CESC cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg04450456 chr4:17643702 FAM184B 0.36 5.16 0.3 4.93e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs644799 1.000 rs481630 chr11:95582447 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.94 13.9 0.65 2.41e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg27121462 chr16:89883253 FANCA 0.74 10.71 0.55 1.74e-22 Vitiligo; CESC cis rs910316 0.763 rs175042 chr14:75470833 A/T cg16144293 chr14:75469539 EIF2B2 0.41 5.45 0.32 1.18e-7 Height; CESC cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg25554036 chr4:6271136 WFS1 0.51 8.37 0.46 3.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs17253792 0.822 rs28831725 chr14:56087569 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs2502731 0.539 rs3003609 chr9:130984755 A/G cg13642260 chr9:130955380 CIZ1 -0.44 -6.56 -0.37 2.8e-10 Attention deficit hyperactivity disorder; CESC cis rs722599 0.748 rs61978932 chr14:75342954 C/T cg11812906 chr14:75593930 NEK9 -0.46 -5.71 -0.33 2.97e-8 IgG glycosylation; CESC trans rs66573146 0.808 rs55942328 chr4:6990960 T/G cg07817883 chr1:32538562 TMEM39B 1.09 7.0 0.4 2.06e-11 Granulocyte percentage of myeloid white cells; CESC cis rs6456156 0.967 rs150108 chr6:167513153 C/T cg07741184 chr6:167504864 NA 0.32 5.44 0.32 1.19e-7 Primary biliary cholangitis; CESC trans rs853679 0.546 rs71537572 chr6:27970715 T/C cg01620082 chr3:125678407 NA -0.76 -6.18 -0.35 2.42e-9 Depression; CESC trans rs7839040 0.698 rs13267308 chr8:82930285 A/G cg14472086 chr9:107730925 NA -0.49 -6.45 -0.37 5.26e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs1832871 0.711 rs7747669 chr6:158664345 A/G cg07165851 chr6:158734300 TULP4 0.6 6.41 0.37 6.66e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07359604 chr15:25415763 SNORD115-1 -0.62 -7.64 -0.42 3.95e-13 Gut microbiome composition (summer); CESC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg22903657 chr4:1355424 KIAA1530 -0.38 -5.18 -0.3 4.5e-7 Obesity-related traits; CESC cis rs9486719 0.895 rs3798294 chr6:97049587 G/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.76 -0.33 2.28e-8 Migraine;Coronary artery disease; CESC trans rs11098499 0.874 rs13123591 chr4:120105990 T/G cg25214090 chr10:38739885 LOC399744 0.57 7.53 0.42 7.93e-13 Corneal astigmatism; CESC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg17971929 chr21:40555470 PSMG1 -0.87 -12.38 -0.61 4.33e-28 Cognitive function; CESC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 6.47 0.37 4.74e-10 Electroencephalogram traits; CESC cis rs6460942 1.000 rs6948314 chr7:12418363 T/A cg02935154 chr7:12443704 VWDE -0.53 -5.99 -0.35 6.68e-9 Coronary artery disease; CESC cis rs9790314 1.000 rs1478565 chr3:161027464 C/T cg04691961 chr3:161091175 C3orf57 -0.45 -5.85 -0.34 1.44e-8 Morning vs. evening chronotype; CESC cis rs7914558 0.966 rs10786745 chr10:104956827 A/G cg08650961 chr10:104748594 CNNM2 0.31 5.04 0.3 8.43e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg11657440 chr19:46296263 DMWD 0.84 12.67 0.61 4.6e-29 Coronary artery disease; CESC cis rs116095464 0.850 rs10055295 chr5:243749 G/A cg22857025 chr5:266934 NA -1.27 -18.37 -0.75 3.49e-49 Breast cancer; CESC cis rs3892630 0.818 rs80137870 chr19:33182750 C/T cg13157960 chr19:33183277 NUDT19 0.52 5.06 0.3 7.77e-7 Red blood cell traits; CESC cis rs4481887 1.000 rs4360555 chr1:248468591 G/T cg00666640 chr1:248458726 OR2T12 0.39 6.36 0.36 8.71e-10 Common traits (Other); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13486387 chr9:94124044 AUH -0.46 -6.16 -0.35 2.75e-9 Fibrinogen levels; CESC cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.83 8.73 0.47 3.01e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg07507251 chr3:52567010 NT5DC2 0.42 7.37 0.41 2.11e-12 Bipolar disorder; CESC cis rs7605827 0.930 rs2287273 chr2:15658523 T/C cg19274914 chr2:15703543 NA 0.37 6.65 0.38 1.65e-10 Educational attainment (years of education); CESC cis rs3741151 0.656 rs11544311 chr11:73106237 A/C cg17517138 chr11:73019481 ARHGEF17 0.98 7.14 0.4 8.91e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs1152591 0.669 rs2978381 chr14:64766652 T/C cg23250157 chr14:64679961 SYNE2 0.43 5.68 0.33 3.53e-8 Atrial fibrillation; CESC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg23708337 chr7:1209742 NA 0.51 5.15 0.3 4.99e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg07945480 chr4:2964972 GRK4;NOP14 0.47 6.11 0.35 3.51e-9 Weight; CESC cis rs7527798 0.592 rs11118359 chr1:207858546 T/C cg21110645 chr1:207815933 NA -0.33 -5.79 -0.33 2.02e-8 Erythrocyte sedimentation rate; CESC cis rs7607369 0.572 rs629177 chr2:219454801 T/G cg02176678 chr2:219576539 TTLL4 0.48 8.27 0.45 6.46e-15 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg12718519 chr1:2058417 PRKCZ -0.26 -5.57 -0.32 6.26e-8 Height; CESC cis rs6120849 0.707 rs6120798 chr20:33610822 T/G cg24642439 chr20:33292090 TP53INP2 0.67 6.67 0.38 1.45e-10 Protein C levels; CESC cis rs2797160 1.000 rs77678056 chr6:126019738 A/G cg05901451 chr6:126070800 HEY2 0.46 6.53 0.37 3.4e-10 Endometrial cancer; CESC cis rs12476592 0.602 rs187801 chr2:63867446 A/C cg17519650 chr2:63277830 OTX1 0.44 5.06 0.3 7.87e-7 Childhood ear infection; CESC cis rs62408225 1.000 rs62408235 chr6:90978383 T/C cg06866423 chr6:90926672 BACH2 0.44 5.27 0.31 2.83e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs2120019 0.938 rs13056 chr15:75312187 A/G cg09165964 chr15:75287851 SCAMP5 -0.77 -9.82 -0.52 1.29e-19 Blood trace element (Zn levels); CESC cis rs12200560 0.505 rs211174 chr6:97071120 C/T cg06623918 chr6:96969491 KIAA0776 0.45 5.6 0.33 5.31e-8 Coronary heart disease; CESC cis rs5753618 0.583 rs5749279 chr22:31854209 A/G cg02404636 chr22:31891804 SFI1 0.4 5.89 0.34 1.18e-8 Colorectal cancer; CESC trans rs1814175 0.587 rs7948538 chr11:50021353 A/C cg03929089 chr4:120376271 NA -0.9 -14.7 -0.67 3.47e-36 Height; CESC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg11494091 chr17:61959527 GH2 -0.39 -5.38 -0.31 1.67e-7 Height; CESC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg05863683 chr7:1912471 MAD1L1 0.4 6.02 0.35 5.89e-9 Bipolar disorder and schizophrenia; CESC cis rs7772486 0.875 rs2748490 chr6:146329681 G/T cg05347473 chr6:146136440 FBXO30 0.49 6.56 0.37 2.8e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg05234568 chr11:5960015 NA -0.65 -8.8 -0.48 1.77e-16 DNA methylation (variation); CESC cis rs11785400 0.793 rs4371985 chr8:143737279 C/T cg24634471 chr8:143751801 JRK 0.45 5.61 0.33 5.01e-8 Schizophrenia; CESC cis rs9905704 0.881 rs2611774 chr17:56732304 G/A cg12560992 chr17:57184187 TRIM37 0.55 6.34 0.36 1e-9 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14965947 chr9:88357129 AGTPBP1 0.58 6.97 0.39 2.51e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs113835537 0.935 rs3867133 chr11:66451962 A/G cg22134325 chr11:66188745 NPAS4 -0.51 -5.93 -0.34 9.62e-9 Airway imaging phenotypes; CESC cis rs8114671 0.562 rs2076667 chr20:33506964 G/A cg07148914 chr20:33460835 GGT7 0.46 6.13 0.35 3.19e-9 Height; CESC cis rs9640161 0.659 rs77354576 chr7:150013300 A/C cg10018233 chr7:150070692 REPIN1 0.48 7.66 0.43 3.4e-13 Blood protein levels;Circulating chemerin levels; CESC cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.13 0.35 3.25e-9 Hip circumference adjusted for BMI; CESC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg24846343 chr22:24311635 DDTL 0.64 10.78 0.55 1.09e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs1728785 1.000 rs821167 chr16:68577222 T/G cg02972257 chr16:68554789 NA -0.62 -6.88 -0.39 4.41e-11 Ulcerative colitis; CESC cis rs667920 0.575 rs9861150 chr3:136183320 G/T cg15507776 chr3:136538369 TMEM22 0.58 6.19 0.36 2.32e-9 Coronary artery disease; CESC trans rs561341 0.739 rs1978116 chr17:30220978 A/C cg20587970 chr11:113659929 NA -0.63 -8.23 -0.45 8.45e-15 Hip circumference adjusted for BMI; CESC cis rs2933343 1.000 rs789237 chr3:128636961 A/C cg25356066 chr3:128598488 ACAD9 0.52 6.46 0.37 4.99e-10 IgG glycosylation; CESC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg11890956 chr21:40555474 PSMG1 1.17 21.95 0.8 1.5e-61 Cognitive function; CESC cis rs473651 0.904 rs501333 chr2:239336045 G/A cg21699342 chr2:239360505 ASB1 0.54 9.23 0.49 8.77e-18 Multiple system atrophy; CESC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.63 0.42 4.23e-13 Prudent dietary pattern; CESC cis rs1448094 0.511 rs17279133 chr12:86162353 G/A cg02569458 chr12:86230093 RASSF9 0.49 7.68 0.43 3.15e-13 Major depressive disorder; CESC cis rs3741489 1.000 rs4758889 chr12:133475533 C/T cg01499426 chr12:133417423 CHFR 0.9 5.59 0.32 5.6e-8 Cognitive function; CESC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg03033257 chr22:50311977 ALG12;CRELD2 -0.5 -5.12 -0.3 5.99e-7 Schizophrenia; CESC cis rs6032067 0.929 rs17424474 chr20:43804797 C/A cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.5e-8 Blood protein levels; CESC cis rs1707322 0.685 rs56177313 chr1:46225806 A/C cg05343316 chr1:45956843 TESK2 0.5 6.16 0.35 2.65e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg05863683 chr7:1912471 MAD1L1 0.4 5.85 0.34 1.42e-8 Schizophrenia; CESC cis rs7264396 0.563 rs7268195 chr20:34339854 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.76 0.38 8.61e-11 Total cholesterol levels; CESC cis rs2288073 0.965 rs10469924 chr2:24416230 G/A cg06627628 chr2:24431161 ITSN2 -0.81 -9.74 -0.51 2.29e-19 Venous thromboembolism (SNP x SNP interaction); CESC cis rs9435341 0.929 rs1762509 chr1:107592959 A/G cg09367891 chr1:107599246 PRMT6 -0.71 -8.38 -0.46 3.17e-15 Facial morphology (factor 21, depth of nasal alae); CESC cis rs72781680 0.716 rs2551334 chr2:24000396 G/A cg08917208 chr2:24149416 ATAD2B 0.57 5.66 0.33 3.89e-8 Lymphocyte counts; CESC cis rs926938 0.527 rs360672 chr1:115483836 C/T cg12756093 chr1:115239321 AMPD1 0.44 6.17 0.35 2.52e-9 Autism; CESC cis rs2732480 0.500 rs2450986 chr12:48661688 G/A cg24011408 chr12:48396354 COL2A1 0.43 6.07 0.35 4.46e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg17366294 chr4:99064904 C4orf37 0.54 7.14 0.4 8.72e-12 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg13795627 chr1:157015873 ARHGEF11 -0.45 -6.18 -0.35 2.36e-9 Fibrinogen levels; CESC cis rs597539 0.690 rs7129960 chr11:68622456 A/G cg21963583 chr11:68658836 MRPL21 0.41 5.55 0.32 6.9e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg06481639 chr22:41940642 POLR3H -0.58 -6.16 -0.35 2.74e-9 Vitiligo; CESC cis rs2243480 1.000 rs2420170 chr7:65656053 T/C cg12463550 chr7:65579703 CRCP -0.73 -5.66 -0.33 4.03e-8 Diabetic kidney disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14374347 chr1:38158195 CDCA8 -0.44 -6.02 -0.35 5.69e-9 Gut microbiota (bacterial taxa); CESC cis rs6594713 0.679 rs9326890 chr5:112859994 C/T cg12552261 chr5:112820674 MCC 0.59 5.73 0.33 2.74e-8 Brain cytoarchitecture; CESC cis rs829883 1.000 rs249837 chr12:98876535 A/G cg25150519 chr12:98850993 NA 0.68 9.06 0.49 2.94e-17 Colorectal adenoma (advanced); CESC cis rs8141529 0.764 rs5762854 chr22:29246278 T/C cg02153584 chr22:29168773 CCDC117 0.65 9.1 0.49 2.26e-17 Lymphocyte counts; CESC cis rs2479724 0.905 rs2149274 chr6:41839092 T/C cg17623882 chr6:41773611 USP49 -0.42 -6.19 -0.36 2.29e-9 Menarche (age at onset); CESC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg13012494 chr21:47604986 C21orf56 -0.44 -5.9 -0.34 1.12e-8 Testicular germ cell tumor; CESC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg26818010 chr10:134567672 INPP5A -0.85 -10.49 -0.54 9.45e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs12824058 0.798 rs4759652 chr12:130808771 C/T cg23887609 chr12:130822674 PIWIL1 0.45 5.81 0.34 1.74e-8 Menopause (age at onset); CESC trans rs4843747 0.671 rs28671027 chr16:88116323 G/A cg26811252 chr16:29126840 RRN3P2 0.71 9.94 0.52 5.41e-20 Menopause (age at onset); CESC cis rs7666738 0.830 rs890470 chr4:98923435 A/C cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -9.15 -0.49 1.58e-17 Mean corpuscular volume; CESC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.29 -0.36 1.3e-9 Total body bone mineral density; CESC cis rs73206853 0.764 rs16940909 chr12:111054591 G/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.77 0.33 2.19e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg15445000 chr17:37608096 MED1 0.39 6.46 0.37 4.99e-10 Glomerular filtration rate (creatinine); CESC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg24531977 chr5:56204891 C5orf35 0.68 9.39 0.5 2.77e-18 Initial pursuit acceleration; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10081138 chr17:7604803 WRAP53 0.46 6.11 0.35 3.53e-9 Fibrinogen levels; CESC cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 5.17 0.3 4.63e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs709400 1.000 rs3915733 chr14:104147353 G/A cg12935359 chr14:103987150 CKB -0.45 -6.04 -0.35 5.3e-9 Body mass index; CESC cis rs56399783 0.901 rs17132594 chr7:2775102 G/A cg19731401 chr7:2775893 GNA12 0.7 6.09 0.35 3.91e-9 Childhood ear infection; CESC trans rs643506 0.874 rs10789849 chr11:111716070 A/C cg11949262 chr7:20816184 NA -0.26 -6.06 -0.35 4.7e-9 Breast cancer; CESC cis rs2637266 0.538 rs11510986 chr10:78415171 C/T cg18941641 chr10:78392320 NA -0.33 -5.2 -0.3 3.99e-7 Pulmonary function; CESC cis rs2440129 0.611 rs11571335 chr17:6904263 C/T cg03760483 chr17:6899297 ALOX12 0.43 7.77 0.43 1.74e-13 Tonsillectomy; CESC cis rs2880765 0.835 rs6497202 chr15:86021375 T/C cg19183879 chr15:85880815 NA -0.25 -5.17 -0.3 4.6e-7 Coronary artery disease; CESC cis rs67460515 0.926 rs11715591 chr3:161043137 C/T cg03342759 chr3:160939853 NMD3 -0.52 -7.4 -0.41 1.81e-12 Parkinson's disease; CESC cis rs977987 0.806 rs12051326 chr16:75437887 G/A cg03315344 chr16:75512273 CHST6 0.41 5.86 0.34 1.35e-8 Dupuytren's disease; CESC trans rs10489896 0.541 rs11578044 chr1:234580945 G/T cg23817893 chr11:86085932 CCDC81 -0.46 -6.5 -0.37 3.93e-10 Cognitive test performance; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08429943 chr16:29606618 NA -0.52 -6.93 -0.39 3.26e-11 Fibrinogen levels; CESC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg23283495 chr1:209979779 IRF6 0.51 7.32 0.41 2.98e-12 Cleft lip with or without cleft palate; CESC cis rs60154123 0.505 rs1319435 chr1:210047618 C/T cg23283495 chr1:209979779 IRF6 -0.51 -5.37 -0.31 1.68e-7 Coronary artery disease; CESC cis rs7512552 0.839 rs2873669 chr1:150426224 C/T cg15654264 chr1:150340011 RPRD2 -0.39 -5.18 -0.3 4.42e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs4253772 0.550 rs739164 chr22:46684558 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.78 -9.2 -0.49 1.09e-17 LDL cholesterol;Cholesterol, total; CESC cis rs826838 1.000 rs7975243 chr12:38849220 C/T cg13010199 chr12:38710504 ALG10B 0.6 8.53 0.46 1.18e-15 Heart rate; CESC cis rs7666738 0.830 rs6532701 chr4:98745134 C/T cg17366294 chr4:99064904 C4orf37 0.58 8.03 0.44 3.26e-14 Colonoscopy-negative controls vs population controls; CESC cis rs7937682 0.855 rs527078 chr11:111479713 T/C cg22437258 chr11:111473054 SIK2 0.72 9.79 0.52 1.59e-19 Primary sclerosing cholangitis; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg10194341 chr6:43027125 KLC4;MRPL2 -0.63 -7.12 -0.4 1.05e-11 Subjective well-being; CESC cis rs763121 0.853 rs2205802 chr22:39046327 T/C cg14440974 chr22:39074834 NA -0.4 -5.48 -0.32 9.77e-8 Menopause (age at onset); CESC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.59 -5.93 -0.34 9.66e-9 Schizophrenia; CESC cis rs7000551 0.556 rs35359294 chr8:22249755 G/A cg12081754 chr8:22256438 SLC39A14 0.92 12.78 0.62 1.89e-29 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs9929218 1.000 rs13333528 chr16:68790502 C/T cg02972257 chr16:68554789 NA 0.54 6.05 0.35 5.02e-9 Colorectal cancer; CESC cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg21226059 chr5:178986404 RUFY1 -0.39 -5.51 -0.32 8.69e-8 Lung cancer; CESC cis rs2204008 0.837 rs7974888 chr12:37945215 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.81 0.34 1.77e-8 Bladder cancer; CESC cis rs2797160 0.651 rs1343121 chr6:126036184 C/T cg05901451 chr6:126070800 HEY2 0.52 7.49 0.42 1.04e-12 Endometrial cancer; CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg18404041 chr3:52824283 ITIH1 -0.33 -5.71 -0.33 3e-8 Electroencephalogram traits; CESC cis rs4555082 0.915 rs66527719 chr14:105750523 C/G cg06808227 chr14:105710500 BRF1 -0.53 -6.41 -0.37 6.64e-10 Mean platelet volume;Platelet distribution width; CESC cis rs9948 0.786 rs62152765 chr2:97440420 G/A cg01990225 chr2:97406019 LMAN2L -0.92 -7.51 -0.42 9.04e-13 Erectile dysfunction and prostate cancer treatment; CESC cis rs6460942 0.597 rs7778131 chr7:12543233 T/G cg02935154 chr7:12443704 VWDE -0.57 -5.58 -0.32 6.01e-8 Coronary artery disease; CESC cis rs7071206 0.947 rs1356090 chr10:79395312 T/C cg07817648 chr10:79422355 NA -0.89 -11.33 -0.57 1.52e-24 Bone mineral density; CESC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg07936489 chr17:37558343 FBXL20 0.81 11.81 0.59 3.83e-26 Glomerular filtration rate (creatinine); CESC cis rs6570726 0.791 rs4332001 chr6:145934841 T/C cg05347473 chr6:146136440 FBXO30 0.5 6.54 0.37 3.15e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs10883723 0.810 rs7912901 chr10:104277440 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.55 7.59 0.42 5.46e-13 Allergic disease (asthma, hay fever or eczema); CESC cis rs854765 0.929 rs854766 chr17:18012775 A/G cg09796270 chr17:17721594 SREBF1 0.4 5.29 0.31 2.56e-7 Total body bone mineral density; CESC cis rs7267979 1.000 rs6037099 chr20:25356876 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.14 -0.74 2.23e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg05564831 chr3:52568323 NT5DC2 0.46 6.93 0.39 3.11e-11 Bipolar disorder; CESC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg27286337 chr10:134555280 INPP5A 0.7 8.11 0.45 1.95e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg24549020 chr5:56110836 MAP3K1 0.68 7.69 0.43 2.85e-13 Initial pursuit acceleration; CESC cis rs12893597 0.715 rs71429953 chr14:76819480 C/T cg20290672 chr14:76816747 NA -0.41 -5.78 -0.33 2.05e-8 Maximal oxygen uptake response; CESC cis rs4979906 0.920 rs11002239 chr10:79443836 A/C cg07817648 chr10:79422355 NA -0.61 -6.5 -0.37 4e-10 Mortality in heart failure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22614265 chr7:100425456 EPHB4 -0.45 -6.48 -0.37 4.39e-10 Gambling; CESC cis rs12950390 0.853 rs8078052 chr17:45859434 A/G cg00777063 chr17:45855553 NA -0.38 -5.71 -0.33 3e-8 IgG glycosylation; CESC cis rs60871478 0.945 rs62432254 chr7:804175 C/T cg05535760 chr7:792225 HEATR2 0.85 10.63 0.55 3.21e-22 Cerebrospinal P-tau181p levels; CESC cis rs1008375 1.000 rs11724495 chr4:17621310 G/A cg15017067 chr4:17643749 FAM184B 0.39 5.62 0.33 4.85e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs501120 1.000 rs493874 chr10:44764077 C/T cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.1e-11 Coronary artery disease;Coronary heart disease; CESC cis rs6835098 0.923 rs9997477 chr4:174112543 C/T cg08422745 chr4:174089978 GALNT7 -0.72 -9.5 -0.5 1.3e-18 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs4237845 0.742 rs6650219 chr12:58289100 T/C cg02175503 chr12:58329896 NA 0.63 9.03 0.49 3.6e-17 Intelligence (multi-trait analysis); CESC cis rs10744422 1.000 rs1587856 chr12:123342229 A/G cg25930673 chr12:123319894 HIP1R -0.81 -6.32 -0.36 1.09e-9 Schizophrenia; CESC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg25036284 chr2:26402008 FAM59B -0.82 -9.33 -0.5 4.31e-18 Gut microbiome composition (summer); CESC cis rs4803468 1.000 rs3810175 chr19:41904396 C/T cg08477640 chr19:41863820 B9D2 -0.38 -5.07 -0.3 7.33e-7 Height; CESC cis rs459571 0.959 rs455381 chr9:136905577 C/A cg13789015 chr9:136890014 NCRNA00094 0.54 7.69 0.43 2.98e-13 Platelet distribution width; CESC cis rs72781680 0.611 rs7602797 chr2:24318148 C/T cg20701182 chr2:24300061 SF3B14 0.92 10.55 0.54 6.09e-22 Lymphocyte counts; CESC cis rs7809799 0.850 rs2894224 chr7:98765616 A/G cg05967295 chr7:98741636 SMURF1 -0.77 -5.41 -0.32 1.37e-7 Ulcerative colitis; CESC cis rs12677618 1.000 rs10092931 chr8:142307201 A/G cg27411547 chr8:142287226 NA -0.41 -5.24 -0.31 3.25e-7 Plateletcrit; CESC trans rs6011002 0.872 rs6010987 chr20:62277675 G/A cg17720233 chr1:151128310 TNFAIP8L2 0.84 6.21 0.36 2.07e-9 Dental caries; CESC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -11.51 -0.58 3.94e-25 Initial pursuit acceleration; CESC cis rs11031096 0.711 rs17283923 chr11:4173841 C/T cg18678763 chr11:4115507 RRM1 -0.45 -6.27 -0.36 1.44e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs3733585 0.605 rs4697708 chr4:10121189 A/G cg00071950 chr4:10020882 SLC2A9 -0.63 -9.88 -0.52 8.39e-20 Cleft plate (environmental tobacco smoke interaction); CESC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg12463550 chr7:65579703 CRCP -0.56 -7.23 -0.41 5.19e-12 Aortic root size; CESC cis rs910316 0.783 rs11850751 chr14:75590113 A/T cg11812906 chr14:75593930 NEK9 0.89 14.79 0.67 1.64e-36 Height; CESC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg21963583 chr11:68658836 MRPL21 0.4 5.71 0.33 3.04e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs8070128 0.583 rs7406982 chr17:17942613 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.62 8.81 0.48 1.7e-16 Total body bone mineral density; CESC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg17949981 chr6:28129498 ZNF389 0.45 5.71 0.33 3.07e-8 Depression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07141622 chr14:70193793 NA 0.57 7.04 0.4 1.64e-11 Gut microbiome composition (summer); CESC cis rs9616064 0.506 rs2073275 chr22:47070432 G/C cg25730555 chr22:47059586 GRAMD4 0.5 6.43 0.37 5.9e-10 Urate levels in obese individuals; CESC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg18016565 chr1:150552671 MCL1 0.34 5.28 0.31 2.67e-7 Tonsillectomy; CESC cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg05234568 chr11:5960015 NA -0.54 -6.5 -0.37 3.92e-10 DNA methylation (variation); CESC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg07936489 chr17:37558343 FBXL20 0.8 11.52 0.58 3.72e-25 Glomerular filtration rate (creatinine); CESC cis rs6502050 0.835 rs7220639 chr17:80146866 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.24 -0.31 3.28e-7 Life satisfaction; CESC cis rs10791097 0.694 rs4937583 chr11:130741606 A/G cg12179176 chr11:130786555 SNX19 0.65 10.06 0.53 2.26e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg23887609 chr12:130822674 PIWIL1 0.45 5.82 0.34 1.69e-8 Menopause (age at onset); CESC cis rs9486719 1.000 rs11153023 chr6:96968525 C/T cg18709589 chr6:96969512 KIAA0776 -0.55 -5.81 -0.34 1.81e-8 Migraine;Coronary artery disease; CESC cis rs1832871 0.683 rs6908487 chr6:158713047 G/T cg07165851 chr6:158734300 TULP4 0.6 6.59 0.38 2.33e-10 Height; CESC cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg00102166 chr1:43425337 SLC2A1 -0.58 -6.38 -0.36 7.94e-10 Monocyte count; CESC cis rs7520050 0.966 rs785520 chr1:46568836 T/C cg03146154 chr1:46216737 IPP -0.43 -5.57 -0.32 6.38e-8 Red blood cell count;Reticulocyte count; CESC cis rs2235544 0.579 rs1537322 chr1:54482306 G/T cg09175620 chr1:54484536 LDLRAD1 -0.29 -5.16 -0.3 4.75e-7 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs34375054 0.526 rs7302475 chr12:125677886 T/C cg25124228 chr12:125621409 AACS -0.5 -5.86 -0.34 1.39e-8 Post bronchodilator FEV1/FVC ratio; CESC cis rs921968 0.565 rs6436081 chr2:219637884 A/G cg02176678 chr2:219576539 TTLL4 -0.43 -7.53 -0.42 7.9e-13 Mean corpuscular hemoglobin concentration; CESC cis rs9814567 0.896 rs6790338 chr3:134208167 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.46 -6.29 -0.36 1.33e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs3749237 0.595 rs4855859 chr3:49526300 C/T cg02487422 chr3:49467188 NICN1 0.56 8.19 0.45 1.09e-14 Resting heart rate; CESC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg26335602 chr6:28129616 ZNF389 0.53 7.06 0.4 1.48e-11 Depression; CESC cis rs2637266 0.703 rs4979829 chr10:78457101 G/A cg18941641 chr10:78392320 NA 0.4 7.21 0.41 5.71e-12 Pulmonary function; CESC cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg18099408 chr3:52552593 STAB1 -0.35 -5.96 -0.34 7.8e-9 Electroencephalogram traits; CESC cis rs8070740 0.838 rs35491297 chr17:5327481 T/G cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.29 0.36 1.34e-9 Menopause (age at onset); CESC cis rs4450798 0.691 rs62234793 chr3:13752409 G/A cg23332027 chr3:13681764 NA 0.4 5.47 0.32 1.05e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2882667 0.858 rs13170388 chr5:138436865 A/G cg04439458 chr5:138467593 SIL1 -0.4 -6.21 -0.36 2.04e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs7809950 0.817 rs2237678 chr7:107203265 T/G cg23024343 chr7:107201750 COG5 -0.59 -7.48 -0.42 1.07e-12 Coronary artery disease; CESC cis rs9486719 0.656 rs4839826 chr6:96853616 A/G cg06623918 chr6:96969491 KIAA0776 -0.74 -8.33 -0.46 4.31e-15 Migraine;Coronary artery disease; CESC cis rs4268898 0.662 rs59996104 chr2:24404064 C/T cg20701182 chr2:24300061 SF3B14 0.73 7.38 0.41 2.1e-12 Asthma; CESC cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.12e-8 Colonoscopy-negative controls vs population controls; CESC cis rs75804782 0.557 rs10178728 chr2:239360121 T/A cg21699342 chr2:239360505 ASB1 -0.41 -5.22 -0.31 3.64e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg06873352 chr17:61820015 STRADA 0.47 6.85 0.39 5.1e-11 Height; CESC trans rs7809799 0.850 rs6956645 chr7:98764021 C/T cg25874421 chr14:90527917 KCNK13 0.65 6.03 0.35 5.41e-9 Ulcerative colitis; CESC cis rs11122272 0.735 rs2808597 chr1:231532351 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -7.66 -0.43 3.45e-13 Hemoglobin concentration; CESC cis rs7607369 0.648 rs55983650 chr2:219654932 T/C cg02176678 chr2:219576539 TTLL4 -0.51 -8.73 -0.47 2.86e-16 Red blood cell count;Amyotrophic lateral sclerosis; CESC trans rs11764590 0.694 rs56072378 chr7:2104364 A/G cg11693508 chr17:37793320 STARD3 0.54 6.1 0.35 3.8e-9 Neuroticism; CESC cis rs9916302 0.706 rs597069 chr17:37458512 G/T cg07936489 chr17:37558343 FBXL20 0.95 10.45 0.54 1.24e-21 Glomerular filtration rate (creatinine); CESC cis rs3026101 0.576 rs56188406 chr17:5316769 T/C cg24500398 chr17:5266808 RABEP1 -0.42 -5.89 -0.34 1.16e-8 Body mass index; CESC cis rs2836974 0.830 rs2735309 chr21:40715313 C/T cg11890956 chr21:40555474 PSMG1 1.02 15.55 0.69 3.4e-39 Cognitive function; CESC cis rs45535039 1.000 rs7482443 chr11:119110272 C/T cg16724696 chr11:118992527 HINFP 0.43 5.36 0.31 1.78e-7 Plateletcrit; CESC cis rs73110464 0.562 rs2363634 chr12:53354683 A/G cg16329197 chr12:53359506 NA -0.7 -10.05 -0.53 2.36e-20 Cancer (pleiotropy); CESC cis rs6938 0.534 rs11854704 chr15:75221015 C/T cg17294928 chr15:75287854 SCAMP5 0.47 6.1 0.35 3.69e-9 Breast cancer; CESC cis rs6547741 1.000 rs2384654 chr2:27847364 C/T cg21248554 chr2:27665150 KRTCAP3 0.25 5.09 0.3 6.73e-7 Oral cavity cancer; CESC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg21433313 chr16:3507492 NAT15 0.6 7.45 0.42 1.34e-12 Tuberculosis; CESC cis rs113835537 0.877 rs77239910 chr11:66329639 G/A cg24851651 chr11:66362959 CCS 0.63 5.69 0.33 3.28e-8 Airway imaging phenotypes; CESC cis rs12579753 0.719 rs10862377 chr12:82270172 C/T cg21193143 chr12:82153300 PPFIA2 -0.34 -5.16 -0.3 4.75e-7 Resting heart rate; CESC cis rs826838 0.935 rs1843639 chr12:39178919 C/A cg13010199 chr12:38710504 ALG10B 0.58 8.08 0.44 2.36e-14 Heart rate; CESC cis rs854765 0.575 rs2955357 chr17:17946401 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.6 -8.42 -0.46 2.43e-15 Total body bone mineral density; CESC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg13607699 chr17:42295918 UBTF 0.56 7.46 0.42 1.27e-12 Total body bone mineral density; CESC cis rs1707322 1.000 rs34444543 chr1:46358862 G/A cg03146154 chr1:46216737 IPP 0.69 9.24 0.49 8.09e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2236918 0.687 rs2797600 chr1:242029331 C/T cg17736920 chr1:242011382 EXO1 0.55 7.02 0.4 1.89e-11 Menopause (age at onset); CESC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg15664640 chr17:80829946 TBCD -0.63 -9.05 -0.49 3.16e-17 Breast cancer; CESC cis rs2439831 1.000 rs2245908 chr15:43731454 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.82 11.64 0.58 1.4e-25 Lung cancer in ever smokers; CESC cis rs10256972 0.900 rs4388364 chr7:1033045 T/G cg07308232 chr7:1071921 C7orf50 -0.46 -6.3 -0.36 1.25e-9 Longevity;Endometriosis; CESC cis rs1568889 1.000 rs12791341 chr11:28335452 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.13 0.53 1.38e-20 Bipolar disorder; CESC cis rs1448094 0.690 rs7132879 chr12:86289864 A/G cg02569458 chr12:86230093 RASSF9 0.38 5.47 0.32 1.03e-7 Major depressive disorder; CESC cis rs17376456 0.569 rs2045020 chr5:93224466 T/C cg21475434 chr5:93447410 FAM172A -0.5 -5.1 -0.3 6.43e-7 Diabetic retinopathy; CESC cis rs1003719 0.715 rs6579 chr21:38568308 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -8.14 -0.45 1.59e-14 Eye color traits; CESC cis rs12136530 0.593 rs12403329 chr1:19735793 G/C cg01832549 chr1:19774989 CAPZB -0.48 -6.3 -0.36 1.25e-9 Lead levels in blood; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg07243700 chr1:100731457 RTCD1 -0.49 -6.75 -0.38 9.55e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs7827545 0.961 rs4909482 chr8:135564786 G/T cg17885191 chr8:135476712 NA 0.48 6.36 0.36 8.96e-10 Hypertension (SNP x SNP interaction); CESC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg16405210 chr4:1374714 KIAA1530 -0.56 -7.58 -0.42 5.79e-13 Longevity; CESC cis rs6831352 0.918 rs29001203 chr4:100053091 A/G cg12011299 chr4:100065546 ADH4 -0.58 -6.6 -0.38 2.17e-10 Alcohol dependence; CESC cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg02297831 chr4:17616191 MED28 0.5 6.08 0.35 4.17e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg03213289 chr20:61660250 NA 0.39 6.16 0.35 2.7e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg06873352 chr17:61820015 STRADA 0.71 12.6 0.61 7.56e-29 Prudent dietary pattern; CESC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg05564831 chr3:52568323 NT5DC2 0.48 8.18 0.45 1.18e-14 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06057141 chr7:45026417 SNORA9;C7orf40 -0.6 -7.15 -0.4 8.65e-12 Gut microbiome composition (summer); CESC cis rs4722166 0.532 rs1880242 chr7:22759607 A/C cg05472934 chr7:22766657 IL6 -0.49 -6.39 -0.37 7.6e-10 Lung cancer; CESC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -7.99 -0.44 4.13e-14 Personality dimensions; CESC cis rs10197940 0.901 rs2290367 chr2:152266731 T/A cg06191203 chr2:152266755 RIF1 -0.56 -7.99 -0.44 4.15e-14 Lung cancer; CESC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg24690094 chr11:67383802 NA 0.43 7.51 0.42 9.04e-13 Mean corpuscular volume; CESC cis rs858239 0.600 rs10266123 chr7:23136487 G/C cg23682824 chr7:23144976 KLHL7 0.51 6.74 0.38 9.98e-11 Cerebrospinal fluid biomarker levels; CESC trans rs1728785 1.000 rs1728789 chr16:68595776 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.84 0.43 1.09e-13 Ulcerative colitis; CESC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.2 0.4 6.31e-12 Bipolar disorder; CESC cis rs6866344 0.601 rs4419608 chr5:178097049 C/T cg10224037 chr5:178157518 ZNF354A 0.52 5.44 0.32 1.24e-7 Neutrophil percentage of white cells; CESC cis rs7267979 0.586 rs1007707 chr20:25190598 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.66 10.86 0.56 5.58e-23 Liver enzyme levels (alkaline phosphatase); CESC cis rs1558375 0.679 rs31672 chr7:87059699 C/T cg00919237 chr7:87102261 ABCB4 0.39 5.4 0.31 1.51e-7 Gallbladder cancer; CESC trans rs2823962 0.759 rs2211988 chr21:18016760 T/C cg06419850 chr17:4688683 VMO1 -0.42 -6.13 -0.35 3.23e-9 Amyotrophic lateral sclerosis; CESC cis rs11098499 0.954 rs4309825 chr4:120314881 C/T cg09307838 chr4:120376055 NA -0.87 -12.2 -0.6 1.84e-27 Corneal astigmatism; CESC cis rs11809207 0.523 rs2783628 chr1:26501827 A/C cg00147160 chr1:26503991 CNKSR1 0.28 5.23 0.31 3.42e-7 Height; CESC cis rs1915146 0.546 rs9422857 chr10:126861278 C/G cg00406319 chr10:126851303 NA 0.38 5.86 0.34 1.34e-8 Menarche (age at onset); CESC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg05025164 chr4:1340916 KIAA1530 -0.69 -9.46 -0.5 1.72e-18 Obesity-related traits; CESC cis rs2599510 0.811 rs176410 chr2:32643437 C/G cg02381751 chr2:32503542 YIPF4 -0.5 -6.49 -0.37 4.14e-10 Interleukin-18 levels; CESC cis rs6967414 0.792 rs6954012 chr7:6755724 A/C cg09896999 chr7:6746977 ZNF12 -0.48 -6.32 -0.36 1.09e-9 Hematocrit;Hemoglobin concentration; CESC cis rs936229 0.813 rs3784790 chr15:75081745 G/C cg14664628 chr15:75095509 CSK -0.95 -14.38 -0.66 4.66e-35 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs1801251 1.000 rs6747645 chr2:233571033 C/T cg25237894 chr2:233734115 C2orf82 -0.49 -8.65 -0.47 5.2e-16 Coronary artery disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00626599 chr2:64068905 UGP2 0.48 6.06 0.35 4.74e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs501120 1.000 rs694425 chr10:44761804 C/G cg09554077 chr10:44749378 NA 0.49 6.06 0.35 4.75e-9 Coronary artery disease;Coronary heart disease; CESC cis rs4481887 0.927 rs6587444 chr1:248438452 C/T cg00666640 chr1:248458726 OR2T12 -0.39 -6.46 -0.37 4.95e-10 Common traits (Other); CESC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -6.94 -0.39 3.02e-11 Total body bone mineral density; CESC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg20203395 chr5:56204925 C5orf35 0.38 5.17 0.3 4.63e-7 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01712359 chr16:88783355 FAM38A -0.54 -6.03 -0.35 5.38e-9 Gut microbiome composition (summer); CESC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg09177884 chr7:1199841 ZFAND2A 0.47 5.8 0.34 1.92e-8 Longevity;Endometriosis; CESC cis rs901683 1.000 rs78913745 chr10:46019911 A/T cg16031567 chr10:46195673 NA -0.77 -5.04 -0.3 8.57e-7 Red blood cell traits;Mean corpuscular volume; CESC cis rs17095355 1.000 rs7905306 chr10:111712902 C/T cg00817464 chr10:111662876 XPNPEP1 -0.45 -5.3 -0.31 2.49e-7 Biliary atresia; CESC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg16405210 chr4:1374714 KIAA1530 0.78 10.72 0.55 1.65e-22 Obesity-related traits; CESC cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg25019033 chr10:957182 NA -0.57 -6.08 -0.35 4.24e-9 Eosinophil percentage of granulocytes; CESC cis rs6540556 0.608 rs2884090 chr1:209884059 C/T cg05527609 chr1:210001259 C1orf107 -0.46 -5.42 -0.32 1.32e-7 Red blood cell count; CESC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg25036284 chr2:26402008 FAM59B 0.86 9.4 0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs6051080 1 rs6051080 chr20:25975674 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.36 5.56 0.32 6.47e-8 Colorectal or endometrial cancer; CESC cis rs6598955 0.670 rs11247892 chr1:26592727 A/G cg00852783 chr1:26633632 UBXN11 0.42 6.23 0.36 1.86e-9 Obesity-related traits; CESC cis rs1005224 0.929 rs11625260 chr14:76162293 G/C cg25116370 chr14:76127843 TTLL5;C14orf1 -0.41 -5.55 -0.32 7.03e-8 Large artery stroke; CESC cis rs1790761 0.505 rs6591256 chr11:67349899 A/G cg24690094 chr11:67383802 NA -0.3 -5.08 -0.3 7.19e-7 Mean corpuscular volume; CESC cis rs12410462 0.579 rs116423559 chr1:227575014 A/G cg04117972 chr1:227635322 NA 0.75 6.11 0.35 3.57e-9 Major depressive disorder; CESC cis rs6568686 0.627 rs403667 chr6:111910604 T/C cg22127309 chr6:111907043 TRAF3IP2 0.53 5.2 0.3 3.91e-7 Depressive and manic episodes in bipolar disorder;Depressive episodes in bipolar disorder; CESC cis rs1005277 0.540 rs7903942 chr10:37929276 C/T cg00409905 chr10:38381863 ZNF37A 0.48 6.47 0.37 4.62e-10 Extrinsic epigenetic age acceleration; CESC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg18301423 chr5:131593218 PDLIM4 0.39 5.18 0.3 4.47e-7 Acylcarnitine levels; CESC cis rs35275482 0.541 rs2099584 chr15:60114161 A/T cg11160654 chr15:60369068 NA 0.34 5.26 0.31 3.04e-7 Gut microbiota (bacterial taxa); CESC cis rs57506017 0.585 rs6460901 chr7:12255434 C/T cg23422036 chr7:12250390 TMEM106B 0.39 5.23 0.31 3.36e-7 Neuroticism; CESC cis rs4975616 0.869 rs452384 chr5:1330840 T/C cg07493874 chr5:1342172 CLPTM1L -0.41 -7.93 -0.44 6.13e-14 Lung cancer; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg13040021 chr20:5093911 C20orf30 0.5 6.7 0.38 1.24e-10 Weight; CESC cis rs10416265 0.503 rs1981818 chr19:33615122 C/T cg27124370 chr19:33622961 WDR88 -0.51 -7.43 -0.42 1.5e-12 Bone properties (heel); CESC cis rs748404 0.560 rs1060939 chr15:43816917 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.48 7.13 0.4 9.52e-12 Lung cancer; CESC cis rs6089584 0.606 rs7270469 chr20:60577258 G/A cg06108461 chr20:60628389 TAF4 -0.55 -7.26 -0.41 4.22e-12 Body mass index; CESC cis rs796364 0.806 rs74266490 chr2:201005995 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.75 -6.83 -0.39 5.71e-11 Schizophrenia; CESC cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg09658497 chr7:2847517 GNA12 -0.34 -5.15 -0.3 5.19e-7 Height; CESC cis rs9324022 0.929 rs17099617 chr14:101170488 A/G cg18089426 chr14:101175970 NA 0.55 6.7 0.38 1.24e-10 Plateletcrit; CESC cis rs11792861 0.781 rs28361152 chr9:111727529 T/C cg13535736 chr9:111863775 C9orf5 -0.47 -6.28 -0.36 1.35e-9 Menarche (age at onset); CESC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg08632164 chr7:65971372 NA -0.42 -5.39 -0.31 1.53e-7 Diabetic kidney disease; CESC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg00800038 chr16:89945340 TCF25 -0.69 -6.6 -0.38 2.24e-10 Skin colour saturation; CESC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg03388025 chr16:89894329 SPIRE2 0.42 8.0 0.44 3.87e-14 Vitiligo; CESC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg23283495 chr1:209979779 IRF6 0.51 7.49 0.42 1.01e-12 Cleft lip with or without cleft palate; CESC cis rs1348850 0.519 rs1527407 chr2:178525630 T/G cg22681709 chr2:178499509 PDE11A -0.49 -7.04 -0.4 1.63e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg24110177 chr3:50126178 RBM5 -0.55 -7.49 -0.42 1.06e-12 Body mass index; CESC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 8.93 0.48 7.4e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4660306 0.961 rs945179 chr1:45992460 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.6 7.55 0.42 7.14e-13 Homocysteine levels; CESC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg06600287 chr1:53387719 ECHDC2 -0.31 -5.42 -0.32 1.31e-7 Monocyte count; CESC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC cis rs2243480 1.000 rs427044 chr7:65508545 G/A cg13147721 chr7:65941812 NA -0.95 -9.01 -0.48 4.11e-17 Diabetic kidney disease; CESC cis rs9660992 0.639 rs1151786 chr1:205227760 G/C cg21643547 chr1:205240462 TMCC2 -0.44 -5.97 -0.34 7.53e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.36 5.32 0.31 2.24e-7 Electroencephalogram traits; CESC cis rs10864907 0.614 rs7557537 chr2:113702530 T/C cg12858261 chr2:113808755 IL1F8 0.45 5.47 0.32 1.03e-7 Pulmonary function; CESC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.61 0.81 8.52e-64 Prudent dietary pattern; CESC cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.09 11.08 0.56 1.09e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -7.04 -0.4 1.69e-11 Extrinsic epigenetic age acceleration; CESC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg16049864 chr8:95962084 TP53INP1 -0.68 -12.07 -0.6 4.85e-27 Type 2 diabetes; CESC cis rs1729951 0.546 rs12054218 chr3:136677496 C/G cg03617693 chr3:136751559 NA 0.38 5.36 0.31 1.81e-7 Neuroticism; CESC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg18099408 chr3:52552593 STAB1 -0.3 -5.11 -0.3 6.18e-7 Bipolar disorder; CESC cis rs9457247 0.967 rs1187532 chr6:167382020 G/A cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.76e-8 Crohn's disease; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg02912187 chr19:18314776 RAB3A 0.42 6.05 0.35 4.81e-9 Vertical cup-disc ratio; CESC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg00934597 chr7:893267 UNC84A 0.54 5.45 0.32 1.16e-7 Cerebrospinal P-tau181p levels; CESC cis rs6061231 0.544 rs2427314 chr20:60973666 C/T cg06197360 chr20:60970103 CABLES2 -0.38 -5.19 -0.3 4.25e-7 Colorectal cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08365438 chr10:21683093 NA -0.45 -6.16 -0.35 2.64e-9 Gut microbiota (bacterial taxa); CESC cis rs2070677 0.935 rs4582924 chr10:135409033 T/G cg20169779 chr10:135381914 SYCE1 -0.75 -9.82 -0.52 1.26e-19 Gout; CESC cis rs826838 0.935 rs1719855 chr12:39127242 C/T cg26384229 chr12:38710491 ALG10B -0.67 -10.95 -0.56 2.81e-23 Heart rate; CESC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg00166722 chr3:10149974 C3orf24 0.49 6.27 0.36 1.47e-9 Alzheimer's disease; CESC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg11890956 chr21:40555474 PSMG1 1.18 23.84 0.83 6.88e-68 Cognitive function; CESC cis rs2228479 0.850 rs11640336 chr16:89941153 T/C cg14709524 chr16:89940631 TCF25 0.69 5.28 0.31 2.75e-7 Skin colour saturation; CESC cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg23711669 chr6:146136114 FBXO30 0.98 15.12 0.68 1.11e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg00409905 chr10:38381863 ZNF37A -0.46 -6.13 -0.35 3.26e-9 Extrinsic epigenetic age acceleration; CESC cis rs9894429 0.700 rs113915083 chr17:79552696 G/C cg21984481 chr17:79567631 NPLOC4 0.57 9.21 0.49 1.01e-17 Eye color traits; CESC cis rs9291683 1.000 rs9291683 chr4:10324160 C/T cg11266682 chr4:10021025 SLC2A9 0.43 7.49 0.42 1.02e-12 Bone mineral density; CESC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.85 7.22 0.41 5.54e-12 Depression; CESC cis rs56046484 0.750 rs62022525 chr15:85523678 G/T cg08123816 chr15:85640762 PDE8A -0.47 -5.07 -0.3 7.4e-7 Testicular germ cell tumor; CESC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.07 -0.3 7.42e-7 Total body bone mineral density; CESC cis rs4481887 0.830 rs28581861 chr1:248506028 T/G cg00666640 chr1:248458726 OR2T12 0.35 6.04 0.35 5.14e-9 Common traits (Other); CESC cis rs6500395 1.000 rs1558815 chr16:48704869 C/A cg04672837 chr16:48644449 N4BP1 -0.51 -6.43 -0.37 6.05e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL -0.86 -7.89 -0.44 8e-14 Depression; CESC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg06219351 chr7:158114137 PTPRN2 -0.49 -7.65 -0.43 3.84e-13 Calcium levels; CESC cis rs9840812 0.691 rs7621025 chr3:136272246 T/C cg15507776 chr3:136538369 TMEM22 0.42 5.1 0.3 6.62e-7 Fibrinogen levels; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg14431266 chr11:67057003 ANKRD13D 0.45 6.15 0.35 2.84e-9 Systemic lupus erythematosus; CESC cis rs3768617 0.811 rs12120747 chr1:183042531 G/A ch.1.3577855R chr1:183094577 LAMC1 0.66 9.05 0.49 3.11e-17 Fuchs's corneal dystrophy; CESC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg17724175 chr1:150552817 MCL1 0.45 7.31 0.41 3.23e-12 Tonsillectomy; CESC cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg06766960 chr11:133703094 NA -0.39 -5.56 -0.32 6.46e-8 Childhood ear infection; CESC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg10691866 chr7:65817282 TPST1 0.31 5.33 0.31 2.06e-7 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16789084 chr11:66234297 PELI3 0.54 6.2 0.36 2.18e-9 Gut microbiome composition (summer); CESC cis rs9323205 0.817 rs56100232 chr14:51699378 A/G cg23942311 chr14:51606299 NA -0.46 -5.5 -0.32 8.99e-8 Cancer; CESC cis rs2073300 0.609 rs1936011 chr20:23341912 G/C cg12062639 chr20:23401060 NAPB 1.0 7.89 0.44 8.19e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg05314606 chr18:46478925 NA -0.46 -6.0 -0.35 6.49e-9 Height; CESC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg18252515 chr7:66147081 NA -0.43 -5.62 -0.33 4.88e-8 Aortic root size; CESC cis rs1372520 0.684 rs2583978 chr4:90750326 A/C cg15133208 chr4:90757351 SNCA -0.4 -5.37 -0.31 1.71e-7 Neuroticism; CESC cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.09e-28 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04078658 chr7:2054064 MAD1L1 0.43 6.53 0.37 3.42e-10 Fibrinogen levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg11037719 chr6:2999695 NQO2 -0.45 -6.27 -0.36 1.43e-9 Gambling; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04765098 chr4:184644154 NA 0.45 6.15 0.35 2.91e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23173032 chr14:50359789 ARF6 -0.4 -6.21 -0.36 2.06e-9 Gambling; CESC cis rs4803468 0.967 rs16975238 chr19:41944985 T/A cg09537434 chr19:41945824 ATP5SL 1.06 19.88 0.77 1.84e-54 Height; CESC trans rs6952808 0.743 rs4721097 chr7:1877503 G/T cg24247370 chr13:99142703 STK24 -0.42 -6.27 -0.36 1.45e-9 Bipolar disorder and schizophrenia; CESC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg24690094 chr11:67383802 NA -0.34 -6.15 -0.35 2.83e-9 Mean corpuscular volume; CESC cis rs3741489 1.000 rs2062162 chr12:133432744 C/T cg01499426 chr12:133417423 CHFR 0.96 6.41 0.37 6.72e-10 Cognitive function; CESC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg06873352 chr17:61820015 STRADA 0.49 7.33 0.41 2.81e-12 Height; CESC cis rs10463316 0.862 rs11747047 chr5:150777953 C/T cg03212797 chr5:150827313 SLC36A1 -0.53 -6.77 -0.38 8.16e-11 Metabolite levels (Pyroglutamine); CESC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg08888203 chr3:10149979 C3orf24 0.49 6.29 0.36 1.3e-9 Alzheimer's disease; CESC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -5.11 -0.3 6.15e-7 Breast cancer; CESC cis rs7267979 0.604 rs242130 chr20:25594020 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.52 -7.97 -0.44 4.67e-14 Liver enzyme levels (alkaline phosphatase); CESC cis rs6740322 0.793 rs13414908 chr2:43546658 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -7.5 -0.42 9.55e-13 Coronary artery disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg00873521 chr9:95056130 IARS;SNORA84 -0.44 -6.25 -0.36 1.62e-9 Gambling; CESC cis rs12540874 0.542 rs4947581 chr7:50565967 G/A cg18232548 chr7:50535776 DDC -0.35 -5.11 -0.3 6.3e-7 Systemic sclerosis; CESC cis rs4974559 0.895 rs10018133 chr4:1338246 C/T cg02980000 chr4:1222292 CTBP1 0.76 6.9 0.39 3.74e-11 Systolic blood pressure; CESC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -6.21 -0.36 2.01e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs959260 1.000 rs7216423 chr17:73365671 T/C cg20590849 chr17:73267439 MIF4GD -0.55 -6.4 -0.37 6.95e-10 Systemic lupus erythematosus; CESC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg26338869 chr17:61819248 STRADA 0.69 9.21 0.49 1.05e-17 Prudent dietary pattern; CESC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.24 -0.31 3.23e-7 Lung cancer; CESC cis rs2250402 0.510 rs6492926 chr15:40325829 T/G cg16127683 chr15:40268777 EIF2AK4 -0.66 -5.61 -0.33 5.18e-8 Corneal curvature; CESC trans rs1814175 0.791 rs9787917 chr11:49937281 C/T cg03929089 chr4:120376271 NA -0.93 -16.26 -0.71 1.03e-41 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14337668 chr9:99883682 NA -0.72 -8.67 -0.47 4.43e-16 Gut microbiome composition (summer); CESC cis rs12973672 0.812 rs13345192 chr19:35756155 A/C cg12095397 chr19:35769544 USF2 -0.5 -6.11 -0.35 3.54e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3008870 0.629 rs12742428 chr1:67426487 A/G cg02640540 chr1:67518911 SLC35D1 0.46 5.58 0.32 5.81e-8 Lymphocyte percentage of white cells; CESC cis rs7666738 0.716 rs9994641 chr4:99101605 C/T cg05340658 chr4:99064831 C4orf37 0.75 10.56 0.54 5.64e-22 Colonoscopy-negative controls vs population controls; CESC trans rs9650657 0.506 rs7823296 chr8:10778546 A/G cg15556689 chr8:8085844 FLJ10661 -0.58 -7.22 -0.41 5.51e-12 Neuroticism; CESC cis rs6582630 0.679 rs7301806 chr12:38596667 G/A cg26384229 chr12:38710491 ALG10B 0.46 6.56 0.37 2.76e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg14159672 chr1:205819179 PM20D1 0.8 12.64 0.61 5.69e-29 Menarche (age at onset); CESC cis rs9796 0.621 rs690733 chr15:41476465 G/A cg20272979 chr15:41787780 ITPKA 0.33 5.09 0.3 6.94e-7 Menopause (age at onset); CESC cis rs142518269 1 rs142518269 chr2:24087095 G/A cg20701182 chr2:24300061 SF3B14 0.78 6.93 0.39 3.11e-11 Mean corpuscular hemoglobin; CESC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg18876405 chr7:65276391 NA -0.51 -7.03 -0.4 1.8e-11 Aortic root size; CESC cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg23711669 chr6:146136114 FBXO30 1.03 15.86 0.7 2.71e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs910316 0.763 rs175490 chr14:75545685 A/G cg08847533 chr14:75593920 NEK9 0.91 15.9 0.7 2.01e-40 Height; CESC cis rs2463822 0.507 rs72919442 chr11:62028707 A/G cg06239285 chr11:62104954 ASRGL1 -1.02 -7.78 -0.43 1.63e-13 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs3087591 0.919 rs9913470 chr17:29566575 A/G cg24425628 chr17:29625626 OMG;NF1 -0.42 -5.23 -0.31 3.47e-7 Hip circumference; CESC cis rs863345 0.935 rs10908678 chr1:158506223 A/T cg12129480 chr1:158549410 OR10X1 -0.32 -6.3 -0.36 1.23e-9 Pneumococcal bacteremia; CESC cis rs35110281 0.641 rs4819283 chr21:45083011 T/A cg21573476 chr21:45109991 RRP1B -0.59 -8.8 -0.48 1.82e-16 Mean corpuscular volume; CESC cis rs1707322 0.638 rs1416706 chr1:46602844 G/A cg03146154 chr1:46216737 IPP -0.6 -7.18 -0.4 7.09e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2637266 1.000 rs12252604 chr10:78352591 T/C cg18941641 chr10:78392320 NA 0.42 7.64 0.42 3.92e-13 Pulmonary function; CESC cis rs1003719 0.715 rs9981715 chr21:38499610 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.47 -0.46 1.69e-15 Eye color traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20029003 chr12:6862076 MLF2 0.54 6.16 0.35 2.7e-9 Gut microbiome composition (summer); CESC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg08704250 chr15:31115839 NA -0.62 -8.0 -0.44 3.91e-14 Huntington's disease progression; CESC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg18446336 chr7:2847575 GNA12 -0.35 -5.24 -0.31 3.27e-7 Height; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg17059624 chr11:85358760 TMEM126A 0.47 6.07 0.35 4.43e-9 Tetralogy of Fallot; CESC cis rs4746818 0.901 rs10740317 chr10:70937566 G/A cg11621586 chr10:70884670 VPS26A 0.86 8.46 0.46 1.83e-15 Left atrial antero-posterior diameter; CESC cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg18180107 chr4:99064573 C4orf37 0.41 5.25 0.31 3.18e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1018836 0.608 rs2205150 chr8:91483232 G/A cg16814680 chr8:91681699 NA -0.55 -7.7 -0.43 2.7e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs2070488 0.965 rs7373828 chr3:38524311 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.94 16.57 0.71 8.37e-43 Electrocardiographic conduction measures; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05226292 chr8:71520850 TRAM1 0.43 6.09 0.35 3.94e-9 Gut microbiota (bacterial taxa); CESC trans rs163030 0.811 rs179814 chr5:76752518 A/T cg26150533 chr8:82396069 FABP4 -0.39 -6.06 -0.35 4.57e-9 Caudate nucleus volume; CESC cis rs2243480 1.000 rs67536397 chr7:65947917 G/A cg13147721 chr7:65941812 NA -0.94 -8.74 -0.47 2.71e-16 Diabetic kidney disease; CESC cis rs2637266 0.600 rs12770441 chr10:78384983 C/T cg18941641 chr10:78392320 NA -0.34 -5.46 -0.32 1.11e-7 Pulmonary function; CESC cis rs10504229 0.593 rs113184543 chr8:58042950 A/G cg24829409 chr8:58192753 C8orf71 -0.5 -6.36 -0.36 8.93e-10 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16505808 chr17:26634458 FLJ40504 -0.51 -6.02 -0.35 5.71e-9 Gut microbiome composition (summer); CESC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg09877947 chr5:131593287 PDLIM4 0.45 5.98 0.34 7.23e-9 Breast cancer; CESC cis rs1372520 0.873 rs2736989 chr4:90776257 T/C cg15133208 chr4:90757351 SNCA -0.37 -5.44 -0.32 1.18e-7 Neuroticism; CESC cis rs662064 0.852 rs617728 chr1:10566522 C/T cg20482658 chr1:10539492 PEX14 0.39 7.82 0.43 1.27e-13 Asthma; CESC cis rs7520050 0.966 rs1707321 chr1:46505309 A/G cg03146154 chr1:46216737 IPP -0.46 -6.11 -0.35 3.64e-9 Red blood cell count;Reticulocyte count; CESC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg16405210 chr4:1374714 KIAA1530 -0.5 -6.15 -0.35 2.79e-9 Obesity-related traits; CESC cis rs2243480 1.000 rs35820085 chr7:65442758 C/T cg18252515 chr7:66147081 NA -1.24 -12.17 -0.6 2.31e-27 Diabetic kidney disease; CESC cis rs11792861 0.816 rs11791845 chr9:111683898 G/A cg05043794 chr9:111880884 C9orf5 -0.36 -5.95 -0.34 8.29e-9 Menarche (age at onset); CESC cis rs4819052 0.851 rs2838866 chr21:46713014 G/C cg11663144 chr21:46675770 NA -0.53 -7.86 -0.43 9.58e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs314370 0.951 rs6706 chr7:100471044 C/T cg10426581 chr7:100472382 SRRT 0.86 8.37 0.46 3.32e-15 Resting heart rate; CESC cis rs10743315 0.557 rs10505840 chr12:19403729 G/T cg02471346 chr12:19282374 PLEKHA5 0.74 5.39 0.31 1.54e-7 Gut microbiota (bacterial taxa); CESC cis rs708547 0.874 rs1718868 chr4:57881215 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.69 7.8 0.43 1.45e-13 Response to bleomycin (chromatid breaks); CESC cis rs763121 0.962 rs909564 chr22:39126508 A/G cg14440974 chr22:39074834 NA -0.36 -5.34 -0.31 1.99e-7 Menopause (age at onset); CESC cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg06108461 chr20:60628389 TAF4 -0.56 -7.43 -0.42 1.54e-12 Body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06987936 chr6:74406097 CD109 0.58 7.05 0.4 1.55e-11 Gut microbiome composition (summer); CESC cis rs9911578 0.967 rs9907940 chr17:56663842 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.11 0.3 6.06e-7 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20150972 chr6:13574573 SIRT5 0.52 6.05 0.35 4.89e-9 Gut microbiome composition (summer); CESC cis rs2204008 0.837 rs11611861 chr12:38357459 A/G cg26384229 chr12:38710491 ALG10B 0.73 10.95 0.56 2.81e-23 Bladder cancer; CESC cis rs9914578 0.943 rs7225843 chr17:2001825 A/G cg16513277 chr17:2031491 SMG6 -0.6 -6.62 -0.38 2.02e-10 Body mass index; CESC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg25767906 chr1:53392781 SCP2 -0.54 -7.54 -0.42 7.6e-13 Monocyte count; CESC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg07701084 chr6:150067640 NUP43 0.41 5.6 0.33 5.23e-8 Lung cancer; CESC cis rs826838 0.900 rs9739128 chr12:38948960 A/T cg13010199 chr12:38710504 ALG10B 0.59 8.5 0.46 1.37e-15 Heart rate; CESC cis rs4704187 0.687 rs4360021 chr5:74421962 A/G cg03227963 chr5:74354835 NA 0.31 5.7 0.33 3.22e-8 Response to amphetamines; CESC cis rs2072732 0.756 rs77415878 chr1:2954047 C/G cg03976712 chr1:2946727 NA 0.34 5.63 0.33 4.57e-8 Plateletcrit; CESC cis rs34330 0.562 rs11055023 chr12:12853197 A/G cg09462578 chr12:12878428 APOLD1 -0.81 -8.63 -0.47 5.89e-16 Systemic lupus erythematosus; CESC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg18230493 chr5:56204884 C5orf35 -0.58 -7.69 -0.43 2.89e-13 Coronary artery disease; CESC cis rs7264396 0.635 rs6058351 chr20:34486093 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.58 7.11 0.4 1.11e-11 Total cholesterol levels; CESC cis rs9815354 0.812 rs73077373 chr3:41852887 C/T cg03022575 chr3:42003672 ULK4 0.7 6.32 0.36 1.08e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9457247 1.000 rs2769352 chr6:167378619 A/G cg07741184 chr6:167504864 NA -0.3 -5.38 -0.31 1.66e-7 Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11897279 chr19:13044638 FARSA 0.49 6.53 0.37 3.33e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs57221529 0.654 rs77015126 chr5:670909 G/A cg25482853 chr8:67687455 SGK3 0.94 9.03 0.49 3.52e-17 Lung disease severity in cystic fibrosis; CESC cis rs11864453 1.000 rs7185407 chr16:72034957 A/T cg16558253 chr16:72132732 DHX38 0.42 5.94 0.34 8.95e-9 Fibrinogen levels; CESC cis rs4253772 0.530 rs9627387 chr22:46684678 A/G cg24881330 chr22:46731750 TRMU 0.83 9.19 0.49 1.17e-17 LDL cholesterol;Cholesterol, total; CESC cis rs965469 1.000 rs6051737 chr20:3296992 G/A cg25506879 chr20:3388711 C20orf194 -0.56 -6.03 -0.35 5.44e-9 IFN-related cytopenia; CESC cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg02187348 chr16:89574699 SPG7 0.55 7.25 0.41 4.59e-12 Multiple myeloma (IgH translocation); CESC cis rs62064224 0.902 rs35830939 chr17:30627564 A/C cg18200150 chr17:30822561 MYO1D 0.53 7.49 0.42 1.01e-12 Schizophrenia; CESC cis rs1707322 0.627 rs3014213 chr1:46045522 T/C cg06784218 chr1:46089804 CCDC17 -0.41 -7.11 -0.4 1.07e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11252926 0.583 rs2066317 chr10:520309 C/T cg18196295 chr10:418757 DIP2C 0.41 5.46 0.32 1.08e-7 Psychosis in Alzheimer's disease; CESC cis rs2742234 0.578 rs2435354 chr10:43652445 C/T cg15436174 chr10:43711423 RASGEF1A -0.5 -5.71 -0.33 2.97e-8 Hirschsprung disease; CESC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg04248312 chr19:17393744 ANKLE1 -0.92 -14.67 -0.67 4.56e-36 Systemic lupus erythematosus; CESC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg23985595 chr17:80112537 CCDC57 0.42 6.52 0.37 3.56e-10 Life satisfaction; CESC cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg17366294 chr4:99064904 C4orf37 0.62 8.8 0.48 1.82e-16 Colonoscopy-negative controls vs population controls; CESC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg22974920 chr21:40686053 BRWD1 -0.46 -5.73 -0.33 2.76e-8 Cognitive function; CESC cis rs6582630 0.519 rs4002440 chr12:38485012 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.95 0.34 8.55e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs7116495 1.000 rs58991229 chr11:71839878 G/A cg26138937 chr11:71823887 C11orf51 0.78 6.17 0.35 2.57e-9 Severe influenza A (H1N1) infection; CESC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg18876405 chr7:65276391 NA 0.5 6.64 0.38 1.75e-10 Aortic root size; CESC cis rs4718428 0.705 rs28648401 chr7:66367132 T/C cg18252515 chr7:66147081 NA -0.45 -5.12 -0.3 5.89e-7 Corneal structure; CESC cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg05585544 chr11:47624801 NA 0.46 6.91 0.39 3.55e-11 Subjective well-being; CESC cis rs5753618 0.583 rs2273249 chr22:31836486 T/C cg13145458 chr22:31556086 RNF185 -0.49 -5.85 -0.34 1.47e-8 Colorectal cancer; CESC trans rs3748784 0.584 rs3748785 chr1:97187083 A/C cg03706951 chr17:39465518 NA 0.34 6.35 0.36 9.51e-10 Headache; CESC cis rs11764590 0.694 rs7797112 chr7:2085165 T/C cg21782813 chr7:2030301 MAD1L1 -0.4 -5.37 -0.31 1.73e-7 Neuroticism; CESC cis rs7927771 1.000 rs12363232 chr11:47623890 C/T cg20307385 chr11:47447363 PSMC3 -0.52 -6.18 -0.35 2.39e-9 Subjective well-being; CESC cis rs3091242 0.809 rs660129 chr1:25727438 C/T cg02931644 chr1:25747376 RHCE 0.38 6.21 0.36 2.06e-9 Erythrocyte sedimentation rate; CESC cis rs13191362 1.000 rs13212608 chr6:163032128 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 5.53 0.32 7.85e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12681288 0.676 rs1562921 chr8:1021986 G/T cg15309053 chr8:964076 NA 0.41 7.0 0.39 2.12e-11 Schizophrenia; CESC cis rs760805 1.000 rs4649037 chr1:25258301 G/T cg22509179 chr1:25234806 RUNX3 -0.6 -8.56 -0.47 9.51e-16 Allergic disease (asthma, hay fever or eczema); CESC trans rs877282 0.947 rs4133015 chr10:774131 T/C cg22713356 chr15:30763199 NA 1.1 10.96 0.56 2.68e-23 Uric acid levels; CESC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg13206674 chr6:150067644 NUP43 0.44 6.45 0.37 5.27e-10 Lung cancer; CESC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.36 -0.31 1.8e-7 Developmental language disorder (linguistic errors); CESC cis rs4654899 0.865 rs957163 chr1:21416181 G/T cg05370193 chr1:21551575 ECE1 0.45 6.78 0.38 7.88e-11 Superior frontal gyrus grey matter volume; CESC cis rs7071206 0.947 rs10509391 chr10:79422369 G/A cg07817648 chr10:79422355 NA -0.89 -11.3 -0.57 2.03e-24 Bone mineral density; CESC cis rs858239 0.600 rs7784929 chr7:23124277 T/C cg23682824 chr7:23144976 KLHL7 0.54 7.58 0.42 5.85e-13 Cerebrospinal fluid biomarker levels; CESC cis rs7589342 0.628 rs11893695 chr2:106401300 C/G cg16077055 chr2:106428750 NCK2 -0.53 -6.75 -0.38 9.15e-11 Addiction; CESC trans rs629535 0.773 rs681534 chr8:70056964 A/C cg21567404 chr3:27674614 NA 0.89 10.42 0.54 1.56e-21 Dupuytren's disease; CESC cis rs4148883 0.689 rs1869458 chr4:100024728 C/G cg12011299 chr4:100065546 ADH4 0.68 10.57 0.54 4.94e-22 Alcohol dependence; CESC cis rs7980687 0.627 rs1727325 chr12:123698332 G/C cg19016782 chr12:123741754 C12orf65 -0.45 -6.51 -0.37 3.65e-10 Height;Educational attainment;Head circumference (infant); CESC cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg12382846 chr20:60892121 LAMA5 0.32 5.12 0.3 5.81e-7 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CESC cis rs6120849 0.662 rs6060300 chr20:33780970 T/C cg24642439 chr20:33292090 TP53INP2 0.57 5.62 0.33 4.91e-8 Protein C levels; CESC cis rs3736485 0.966 rs11070856 chr15:51853817 C/T cg08986416 chr15:51914746 DMXL2 -0.4 -5.13 -0.3 5.5e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC trans rs2983496 0.901 rs57522289 chr6:166037874 A/C cg24191426 chr17:17908098 LRRC48 0.56 6.02 0.35 5.68e-9 Cortisol levels (saliva); CESC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg16489826 chr6:160211363 TCP1;MRPL18 -0.77 -10.88 -0.56 4.85e-23 Age-related macular degeneration (geographic atrophy); CESC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg04369109 chr6:150039330 LATS1 -0.39 -5.61 -0.33 4.97e-8 Lung cancer; CESC cis rs7178572 0.524 rs7163503 chr15:77493505 C/A cg22256960 chr15:77711686 NA -0.53 -6.69 -0.38 1.33e-10 Type 2 diabetes; CESC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg13206674 chr6:150067644 NUP43 0.41 5.74 0.33 2.64e-8 Lung cancer; CESC cis rs12681366 0.620 rs2930968 chr8:95462695 C/T cg13257157 chr8:95487014 RAD54B 0.39 5.34 0.31 2.04e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg23048001 chr7:2026167 MAD1L1 0.48 6.14 0.35 3.02e-9 Bipolar disorder and schizophrenia; CESC cis rs722599 0.715 rs12147629 chr14:75307588 A/G cg08847533 chr14:75593920 NEK9 -0.5 -6.12 -0.35 3.37e-9 IgG glycosylation; CESC cis rs10832963 0.847 rs4237722 chr11:18639363 T/C cg09201001 chr11:18656081 SPTY2D1 0.75 10.3 0.53 3.81e-21 Breast cancer; CESC cis rs2243480 1.000 rs1392104 chr7:65759107 G/A cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs6967414 0.681 rs2881352 chr7:6753511 T/A cg09896999 chr7:6746977 ZNF12 -0.59 -7.11 -0.4 1.05e-11 Hematocrit;Hemoglobin concentration; CESC cis rs9913156 0.793 rs56020376 chr17:4560909 A/G cg19197139 chr17:4613644 ARRB2 0.92 10.46 0.54 1.18e-21 Lymphocyte counts; CESC cis rs10876993 0.749 rs703832 chr12:58024626 G/C cg18357645 chr12:58087776 OS9 0.59 8.7 0.47 3.64e-16 Celiac disease or Rheumatoid arthritis; CESC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.03 12.0 0.59 8.71e-27 Platelet count; CESC cis rs36051895 0.632 rs7871515 chr9:5175288 A/G cg02405213 chr9:5042618 JAK2 0.5 6.36 0.36 8.9e-10 Pediatric autoimmune diseases; CESC trans rs8057939 0.528 rs79253352 chr16:49437248 G/T cg15532236 chr6:170188124 NA 0.49 6.1 0.35 3.68e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs3747547 0.710 rs16934659 chr9:37950604 T/C cg13774184 chr9:37916125 SHB -0.56 -5.87 -0.34 1.32e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs7944735 0.607 rs34895872 chr11:48021778 A/G cg15704280 chr7:45808275 SEPT13 0.68 8.2 0.45 1.02e-14 Intraocular pressure; CESC cis rs9611565 0.512 rs1534932 chr22:42150146 C/T cg03806693 chr22:41940476 POLR3H 1.19 13.82 0.65 4.33e-33 Vitiligo; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12868019 chr2:161126642 NA -0.43 -6.07 -0.35 4.34e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg05313129 chr8:58192883 C8orf71 -0.47 -5.13 -0.3 5.63e-7 Developmental language disorder (linguistic errors); CESC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg07157834 chr1:205819609 PM20D1 0.53 7.98 0.44 4.42e-14 Monocyte percentage of white cells; CESC cis rs9815354 0.951 rs1717018 chr3:41913617 G/A cg03022575 chr3:42003672 ULK4 0.44 5.16 0.3 4.85e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs12464559 0.522 rs10200512 chr2:152626147 T/C cg01189475 chr2:152685088 ARL5A 0.72 7.14 0.4 8.85e-12 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.6 6.8 0.39 6.87e-11 Lung function (FEV1/FVC); CESC trans rs2018683 0.745 rs917217 chr7:28975025 G/T cg19402173 chr7:128379420 CALU 0.56 7.38 0.41 2.07e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg23708337 chr7:1209742 NA 0.54 5.38 0.31 1.61e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -11.97 -0.59 1.09e-26 Alzheimer's disease; CESC cis rs7843479 0.965 rs9314269 chr8:21804989 A/G cg17168535 chr8:21777572 XPO7 0.5 6.74 0.38 9.83e-11 Mean corpuscular volume; CESC cis rs67478160 0.643 rs12878868 chr14:104233725 G/A cg08213375 chr14:104286397 PPP1R13B 0.55 11.0 0.56 1.96e-23 Schizophrenia; CESC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg23758822 chr17:41437982 NA 1.05 16.17 0.7 2.15e-41 Menopause (age at onset); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05366272 chr2:95831943 ZNF2 -0.48 -6.76 -0.38 8.57e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2985684 1.000 rs1952012 chr14:50098896 T/A cg02151108 chr14:50098012 C14orf104 -0.42 -5.48 -0.32 9.97e-8 Carotid intima media thickness; CESC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg08736216 chr1:53307985 ZYG11A -0.42 -7.0 -0.39 2.12e-11 Monocyte count; CESC cis rs7772486 0.806 rs2247317 chr6:146217570 C/T cg23711669 chr6:146136114 FBXO30 0.77 10.91 0.56 3.81e-23 Lobe attachment (rater-scored or self-reported); CESC cis rs7914558 1.000 rs11191542 chr10:104824324 T/A cg08650961 chr10:104748594 CNNM2 0.31 5.17 0.3 4.67e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC trans rs7824557 0.527 rs2736298 chr8:11235136 C/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.05 -0.35 4.93e-9 Retinal vascular caliber; CESC cis rs1348850 0.747 rs1047884 chr2:178488281 C/G cg23306229 chr2:178417860 TTC30B 0.49 6.22 0.36 1.95e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11530914 chr16:67281528 FHOD1;SLC9A5 0.48 6.67 0.38 1.5e-10 Systemic lupus erythematosus; CESC cis rs752010 0.619 rs1123483 chr1:42114198 C/T cg06885757 chr1:42089581 HIVEP3 -0.62 -9.89 -0.52 7.83e-20 Lupus nephritis in systemic lupus erythematosus; CESC cis rs12579753 0.879 rs11115007 chr12:82164673 A/T cg21193143 chr12:82153300 PPFIA2 -0.35 -5.28 -0.31 2.68e-7 Resting heart rate; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09060588 chr6:88299742 ORC3L;RARS2 -0.54 -6.59 -0.38 2.37e-10 Ulcerative colitis; CESC cis rs6460942 0.591 rs4721082 chr7:12341804 A/G cg06484146 chr7:12443880 VWDE -0.62 -6.8 -0.39 6.82e-11 Coronary artery disease; CESC cis rs950776 0.506 rs12915366 chr15:78831753 G/A cg06917634 chr15:78832804 PSMA4 0.81 12.07 0.6 5.08e-27 Sudden cardiac arrest; CESC cis rs2932538 0.922 rs36029940 chr1:113106444 T/G cg22162597 chr1:113214053 CAPZA1 0.6 7.33 0.41 2.75e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs75804782 0.641 rs77448526 chr2:239353487 A/C cg18131467 chr2:239335373 ASB1 -0.67 -5.91 -0.34 1.06e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs72627123 0.867 rs113768127 chr14:74467839 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.79 5.74 0.33 2.6e-8 Morning vs. evening chronotype; CESC cis rs4474465 0.688 rs7124803 chr11:78280822 T/G cg01578073 chr11:78285783 NARS2 -0.45 -5.18 -0.3 4.31e-7 Alzheimer's disease (survival time); CESC cis rs9837602 0.872 rs35154249 chr3:99738230 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.47 6.07 0.35 4.47e-9 Breast cancer; CESC cis rs7084402 0.967 rs1658496 chr10:60279909 G/A cg07615347 chr10:60278583 BICC1 -0.58 -9.3 -0.5 5.46e-18 Refractive error; CESC cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg15605315 chr1:45957053 TESK2 0.5 6.64 0.38 1.76e-10 High light scatter reticulocyte count; CESC cis rs7762018 0.505 rs79843499 chr6:170068420 A/G cg15199489 chr6:170068458 WDR27 0.68 5.2 0.3 4.03e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs909674 0.865 rs5757683 chr22:39850174 G/A cg05872129 chr22:39784769 NA -0.81 -10.48 -0.54 9.64e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs10129255 0.957 rs11846893 chr14:107187307 T/C cg23076370 chr14:107095027 NA -0.49 -6.36 -0.36 8.9e-10 Kawasaki disease; CESC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg08470875 chr2:26401718 FAM59B 0.75 7.79 0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg00802000 chr16:706648 WDR90 -0.43 -6.59 -0.38 2.32e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14975318 chr11:17298537 NUCB2 0.51 6.26 0.36 1.53e-9 Gut microbiome composition (summer); CESC cis rs3812565 0.506 rs8413 chr9:139323311 T/C cg14169450 chr9:139327907 INPP5E 0.53 7.98 0.44 4.35e-14 Granulocyte percentage of myeloid white cells; CESC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.58 7.51 0.42 8.95e-13 Prudent dietary pattern; CESC cis rs965469 1.000 rs6051809 chr20:3352551 A/C cg25506879 chr20:3388711 C20orf194 -0.58 -6.14 -0.35 3.03e-9 IFN-related cytopenia; CESC cis rs4803468 1.000 rs4803463 chr19:41911040 C/G cg09537434 chr19:41945824 ATP5SL -1.04 -18.7 -0.75 2.39e-50 Height; CESC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.55 -7.31 -0.41 3.22e-12 Menarche (age at onset); CESC trans rs10176755 1.000 rs10176755 chr2:171365889 C/T cg02062816 chr1:163166949 RGS5 -0.67 -6.12 -0.35 3.34e-9 Visceral fat; CESC cis rs782590 0.902 rs7582278 chr2:55742924 C/G cg18811423 chr2:55921094 PNPT1 0.79 12.44 0.61 2.73e-28 Metabolic syndrome; CESC cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg23711669 chr6:146136114 FBXO30 1.02 15.88 0.7 2.3e-40 Lobe attachment (rater-scored or self-reported); CESC cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg15556689 chr8:8085844 FLJ10661 0.46 5.51 0.32 8.3e-8 Red cell distribution width; CESC cis rs367615 0.661 rs9326775 chr5:108836925 A/T cg17395555 chr5:108820864 NA 0.62 11.06 0.56 1.27e-23 Colorectal cancer (SNP x SNP interaction); CESC cis rs2540647 0.908 rs2540652 chr22:18973314 G/A cg12798833 chr22:18958832 DGCR5 0.62 6.46 0.37 5e-10 Blood metabolite ratios; CESC cis rs9916302 0.706 rs12947506 chr17:37707592 A/G cg00129232 chr17:37814104 STARD3 -0.54 -5.64 -0.33 4.31e-8 Glomerular filtration rate (creatinine); CESC cis rs35995292 0.500 rs6955677 chr7:38933942 C/T cg19327137 chr7:38886074 VPS41 0.67 11.01 0.56 1.76e-23 Subjective well-being (multi-trait analysis); CESC cis rs6088590 0.687 rs6088582 chr20:33286798 G/A cg24642439 chr20:33292090 TP53INP2 0.69 9.25 0.49 7.76e-18 Coronary artery disease; CESC cis rs9388451 0.839 rs4897155 chr6:126095144 C/A cg05901451 chr6:126070800 HEY2 -0.63 -9.26 -0.49 7.05e-18 Brugada syndrome; CESC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg26338869 chr17:61819248 STRADA 0.72 9.36 0.5 3.63e-18 Prudent dietary pattern; CESC cis rs3925075 1.000 rs9673405 chr16:31347599 A/C cg02846316 chr16:31340340 ITGAM 0.41 6.52 0.37 3.54e-10 IgA nephropathy; CESC cis rs4132509 0.793 rs10927047 chr1:243803677 A/T cg21452805 chr1:244014465 NA 0.66 7.34 0.41 2.57e-12 RR interval (heart rate); CESC cis rs7771547 0.573 rs9470278 chr6:36399239 G/A cg04289385 chr6:36355825 ETV7 -0.38 -5.57 -0.32 6.41e-8 Platelet distribution width; CESC trans rs61931739 0.500 rs10772163 chr12:34532950 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 8.03e-13 Morning vs. evening chronotype; CESC cis rs2228479 0.867 rs35542367 chr16:89965825 G/C cg06558623 chr16:89946397 TCF25 1.06 9.08 0.49 2.48e-17 Skin colour saturation; CESC cis rs7851660 0.527 rs7870795 chr9:100574120 A/G cg13688889 chr9:100608707 NA -0.88 -14.05 -0.65 7.06e-34 Strep throat; CESC cis rs5753618 0.519 rs5997939 chr22:31677130 C/G cg00478049 chr22:31556069 RNF185 0.46 5.21 0.3 3.75e-7 Colorectal cancer; CESC trans rs12356475 0.710 rs10822686 chr10:67733250 C/T cg01087832 chr11:68039514 C11orf24 0.49 6.04 0.35 5.21e-9 Psoriatic arthritis; CESC cis rs7208859 0.673 rs9915963 chr17:29019643 C/T cg14008862 chr17:28927542 LRRC37B2 0.59 5.18 0.3 4.49e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs9929218 1.000 rs9936621 chr16:68798682 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.44 -0.46 2.13e-15 Colorectal cancer; CESC cis rs941873 0.772 rs7920127 chr10:81122914 T/C cg08514558 chr10:81106712 PPIF 0.34 5.9 0.34 1.13e-8 Height; CESC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg04553112 chr3:125709451 NA -0.51 -5.36 -0.31 1.78e-7 Blood pressure (smoking interaction); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg25079743 chr16:30441674 DCTPP1 -0.44 -6.52 -0.37 3.47e-10 Gambling; CESC cis rs2737618 0.722 rs2821333 chr1:200093253 A/C cg21825944 chr1:200113062 NR5A2 -0.38 -5.4 -0.32 1.45e-7 Uric acid levels; CESC cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg15485101 chr11:133734466 NA 0.41 6.67 0.38 1.48e-10 Childhood ear infection; CESC cis rs8070740 0.898 rs8078914 chr17:5323924 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.35 0.36 9.3e-10 Menopause (age at onset); CESC cis rs13102973 0.965 rs28769289 chr4:135878230 T/C cg14419869 chr4:135874104 NA -0.37 -5.75 -0.33 2.42e-8 Subjective well-being; CESC trans rs4332037 0.754 rs62436669 chr7:1926636 G/A cg11693508 chr17:37793320 STARD3 0.64 6.18 0.35 2.43e-9 Bipolar disorder; CESC cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg27297192 chr10:134578999 INPP5A 0.4 5.29 0.31 2.59e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs523522 0.962 rs12309824 chr12:120990582 A/C cg27279351 chr12:120934652 DYNLL1 0.68 8.7 0.47 3.47e-16 High light scatter reticulocyte count; CESC cis rs6456156 0.565 rs2181058 chr6:167465330 A/T cg23791538 chr6:167370224 RNASET2 -0.49 -6.37 -0.36 8.13e-10 Primary biliary cholangitis; CESC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs12618769 0.597 rs3769716 chr2:99133305 G/A cg10123293 chr2:99228465 UNC50 0.39 5.13 0.3 5.6e-7 Bipolar disorder; CESC cis rs61542988 0.570 rs7781074 chr7:22826360 A/G cg13679077 chr7:22862647 TOMM7 -0.62 -7.1 -0.4 1.17e-11 Fibrinogen levels; CESC cis rs10752881 1.000 rs6697739 chr1:182983333 A/C ch.1.3577855R chr1:183094577 LAMC1 0.83 13.25 0.63 4.18e-31 Colorectal cancer; CESC cis rs734999 0.588 rs10910099 chr1:2533552 G/T cg20673091 chr1:2541236 MMEL1 -0.43 -7.1 -0.4 1.12e-11 Ulcerative colitis; CESC cis rs1372520 0.627 rs2737025 chr4:90719192 A/G cg15133208 chr4:90757351 SNCA -0.43 -5.74 -0.33 2.63e-8 Neuroticism; CESC cis rs9300255 0.602 rs1106241 chr12:123627016 T/C cg05973401 chr12:123451056 ABCB9 0.52 5.82 0.34 1.74e-8 Neutrophil percentage of white cells; CESC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg18404041 chr3:52824283 ITIH1 -0.39 -6.64 -0.38 1.81e-10 Bipolar disorder; CESC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.09 0.4 1.22e-11 Cognitive function; CESC cis rs2204008 0.805 rs4589389 chr12:37946120 C/A cg26384229 chr12:38710491 ALG10B -0.56 -8.05 -0.44 2.86e-14 Bladder cancer; CESC cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg19077165 chr18:44547161 KATNAL2 -0.53 -7.55 -0.42 6.82e-13 Personality dimensions; CESC cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg26597838 chr10:835615 NA 1.18 11.3 0.57 2e-24 Eosinophil percentage of granulocytes; CESC cis rs6754311 0.773 rs4988183 chr2:136622046 T/C cg07169764 chr2:136633963 MCM6 0.65 8.31 0.45 5.05e-15 Mosquito bite size; CESC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg02574844 chr11:5959923 NA -0.48 -6.51 -0.37 3.67e-10 DNA methylation (variation); CESC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg22535103 chr8:58192502 C8orf71 -0.92 -10.19 -0.53 8.81e-21 Developmental language disorder (linguistic errors); CESC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg24675658 chr1:53192096 ZYG11B 0.54 6.8 0.39 6.96e-11 Monocyte count; CESC cis rs7100689 0.646 rs10736348 chr10:82139244 C/A cg00277334 chr10:82204260 NA -0.59 -7.72 -0.43 2.46e-13 Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00196167 chr7:139026058 C7orf55 0.56 6.58 0.37 2.44e-10 Gut microbiome composition (summer); CESC cis rs9287719 0.967 rs12622765 chr2:10728331 T/C cg00105475 chr2:10696890 NA 0.39 5.69 0.33 3.35e-8 Prostate cancer; CESC cis rs7116495 1.000 rs7101701 chr11:71762155 A/G cg10381502 chr11:71823885 C11orf51 -0.66 -5.35 -0.31 1.89e-7 Severe influenza A (H1N1) infection; CESC cis rs6500395 0.926 rs1039342 chr16:48577498 G/A cg04672837 chr16:48644449 N4BP1 0.48 6.03 0.35 5.53e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4835473 0.932 rs7693772 chr4:144886767 C/G cg25736465 chr4:144833511 NA 0.42 6.79 0.38 7.41e-11 Immature fraction of reticulocytes; CESC cis rs12711979 0.765 rs897069 chr2:3818947 C/T cg17052675 chr2:3827356 NA 0.43 6.71 0.38 1.16e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs854765 0.693 rs12936037 chr17:17777245 A/G cg09796270 chr17:17721594 SREBF1 -0.45 -6.31 -0.36 1.14e-9 Total body bone mineral density; CESC cis rs9399135 0.967 rs2297338 chr6:135375762 G/A cg22676075 chr6:135203613 NA 0.52 7.31 0.41 3.24e-12 Red blood cell count; CESC cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg06027949 chr8:82754900 SNX16 -0.43 -5.14 -0.3 5.37e-7 Diastolic blood pressure; CESC cis rs2337406 0.714 rs7150993 chr14:107226748 A/T cg07958169 chr14:107095056 NA -0.48 -5.25 -0.31 3.13e-7 Alzheimer's disease (late onset); CESC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg16325326 chr1:53192061 ZYG11B 0.89 15.11 0.68 1.2e-37 Monocyte count; CESC cis rs7635838 0.617 rs184700 chr3:11293061 A/G cg00170343 chr3:11313890 ATG7 0.56 7.69 0.43 2.9e-13 HDL cholesterol; CESC cis rs131777 0.547 rs131753 chr22:51022862 A/G cg00083937 chr22:51039805 MAPK8IP2 0.4 5.73 0.33 2.69e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC trans rs7607369 0.679 rs6751527 chr2:219630965 C/G cg15547669 chr20:2781122 CPXM1 0.37 6.06 0.35 4.58e-9 Red blood cell count;Amyotrophic lateral sclerosis; CESC trans rs931812 0.895 rs4734016 chr8:101910071 C/T cg20993868 chr7:22813445 NA 0.57 8.08 0.44 2.36e-14 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs2658782 0.789 rs3020057 chr11:93118515 C/T cg15737290 chr11:93063684 CCDC67 0.54 6.61 0.38 2.06e-10 Pulmonary function decline; CESC cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg15556689 chr8:8085844 FLJ10661 -0.62 -7.81 -0.43 1.36e-13 Neuroticism; CESC cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg22875332 chr1:76189707 ACADM -0.76 -11.73 -0.58 7.41e-26 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1595825 0.891 rs77946222 chr2:198533251 C/T cg10820045 chr2:198174542 NA 0.41 5.07 0.3 7.49e-7 Ulcerative colitis; CESC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg21280719 chr6:42927975 GNMT -0.3 -6.94 -0.39 3e-11 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg12311346 chr5:56204834 C5orf35 -0.71 -8.63 -0.47 5.64e-16 Initial pursuit acceleration; CESC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg16405210 chr4:1374714 KIAA1530 -0.42 -5.07 -0.3 7.4e-7 Obesity-related traits; CESC trans rs6499100 1.000 rs1833196 chr16:52821090 A/G cg02125191 chr6:41755473 TOMM6 0.5 6.23 0.36 1.78e-9 Tetralogy of Fallot; CESC cis rs72627123 0.867 rs57482759 chr14:74485523 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.65 0.33 4.06e-8 Morning vs. evening chronotype; CESC cis rs3733585 0.673 rs4627861 chr4:9954238 T/G cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg13114125 chr14:105738426 BRF1 -0.9 -10.88 -0.56 4.79e-23 Mean platelet volume;Platelet distribution width; CESC cis rs12602486 1.000 rs78867692 chr17:42263873 G/C cg08193365 chr17:42277699 NA 0.88 5.33 0.31 2.13e-7 Glycated hemoglobin levels; CESC trans rs1728785 1.000 rs1645927 chr16:68589300 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 7.81 0.43 1.32e-13 Ulcerative colitis; CESC cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg24130564 chr14:104152367 KLC1 -0.49 -6.46 -0.37 4.96e-10 Reticulocyte count; CESC cis rs17253792 0.822 rs75232282 chr14:56067290 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.82 6.15 0.35 2.84e-9 Putamen volume; CESC cis rs6032067 1.000 rs34885285 chr20:43804789 C/A cg11264863 chr20:43835661 SEMG1 0.51 5.56 0.32 6.5e-8 Blood protein levels; CESC cis rs9811920 0.598 rs793470 chr3:99548274 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 9.0 0.48 4.52e-17 Axial length; CESC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg23281280 chr6:28129359 ZNF389 0.56 7.62 0.42 4.55e-13 Parkinson's disease; CESC cis rs7772486 0.875 rs2748502 chr6:146298239 A/G cg23711669 chr6:146136114 FBXO30 0.78 11.25 0.57 2.92e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg23711669 chr6:146136114 FBXO30 0.88 11.55 0.58 2.79e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs2842992 0.830 rs1535475 chr6:160148935 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.82 0.48 1.56e-16 Age-related macular degeneration (geographic atrophy); CESC cis rs67478160 0.643 rs4900600 chr14:104291839 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.14 -0.4 8.85e-12 Schizophrenia; CESC cis rs6570726 0.935 rs411641 chr6:145827532 G/A cg23711669 chr6:146136114 FBXO30 0.8 11.97 0.59 1.1e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.94 0.56 3.23e-23 Alzheimer's disease; CESC cis rs916888 0.773 rs199443 chr17:44819565 C/T cg01570182 chr17:44337453 NA 0.86 9.92 0.52 6.21e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs1018836 0.923 rs7826178 chr8:91649592 C/A cg16814680 chr8:91681699 NA -0.78 -12.1 -0.6 4.08e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg11764359 chr7:65958608 NA -0.78 -11.54 -0.58 3.08e-25 Aortic root size; CESC cis rs4076764 0.801 rs6675964 chr1:163375960 A/G cg24596788 chr1:163392923 NA -0.42 -5.99 -0.35 6.85e-9 Motion sickness; CESC cis rs12042938 0.579 rs980394 chr1:231779507 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.4 -5.17 -0.3 4.59e-7 Neuranatomic and neurocognitive phenotypes; CESC cis rs2180341 1.000 rs2057223 chr6:127637374 T/C cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6.31e-39 Breast cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg03209809 chr3:126422892 CHCHD6 -0.54 -7.25 -0.41 4.63e-12 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs9467711 0.559 rs13208916 chr6:26601940 G/A cg14345882 chr6:26364793 BTN3A2 0.56 6.06 0.35 4.58e-9 Autism spectrum disorder or schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11342046 chr2:242641489 ING5 0.46 6.07 0.35 4.32e-9 Gut microbiota (bacterial taxa); CESC cis rs8133932 0.654 rs7410105 chr21:47332181 A/G cg14185626 chr21:47401492 COL6A1 0.51 5.11 0.3 6.11e-7 Schizophrenia; CESC cis rs2243480 1.000 rs1715235 chr7:65488394 T/C cg12463550 chr7:65579703 CRCP 0.72 5.81 0.34 1.8e-8 Diabetic kidney disease; CESC trans rs9325144 0.555 rs61929925 chr12:38698828 C/A cg23762105 chr12:34175262 ALG10 0.49 6.42 0.37 6.4e-10 Morning vs. evening chronotype; CESC cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg10556349 chr10:835070 NA 0.72 6.12 0.35 3.29e-9 Eosinophil percentage of granulocytes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07701084 chr6:150067640 NUP43 -0.58 -6.78 -0.38 7.98e-11 Gut microbiome composition (summer); CESC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg27286337 chr10:134555280 INPP5A 0.68 7.71 0.43 2.62e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg00149659 chr3:10157352 C3orf10 -0.98 -11.21 -0.57 3.88e-24 Alzheimer's disease; CESC cis rs60154123 0.615 rs701943 chr1:210425727 A/G cg25204440 chr1:209979598 IRF6 -0.48 -5.48 -0.32 1.01e-7 Coronary artery disease; CESC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.86 0.39 4.85e-11 Bipolar disorder; CESC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs6942756 0.531 rs9649531 chr7:128927659 T/C cg02491457 chr7:128862824 NA 0.46 6.42 0.37 6.22e-10 White matter hyperintensity burden; CESC cis rs2197308 0.765 rs2387436 chr12:37935337 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.31 -0.41 3.08e-12 Morning vs. evening chronotype; CESC cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg19717773 chr7:2847554 GNA12 -0.54 -8.46 -0.46 1.83e-15 Height; CESC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg25072359 chr17:41440525 NA 0.5 6.83 0.39 5.65e-11 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15717853 chr1:182573596 RGS16 -0.4 -6.21 -0.36 2.01e-9 Gambling; CESC cis rs6439153 0.933 rs34193129 chr3:128691407 G/A cg24203234 chr3:128598194 ACAD9 0.42 5.47 0.32 1.06e-7 Pneumococcal bacteremia; CESC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg25036284 chr2:26402008 FAM59B -0.88 -9.99 -0.52 3.83e-20 Gut microbiome composition (summer); CESC cis rs72781680 0.611 rs72781695 chr2:24266744 T/C cg20701182 chr2:24300061 SF3B14 0.94 10.66 0.55 2.67e-22 Lymphocyte counts; CESC cis rs7577696 0.513 rs212685 chr2:32434701 A/G cg02381751 chr2:32503542 YIPF4 0.46 5.42 0.32 1.31e-7 Inflammatory biomarkers; CESC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg24372256 chr21:43528868 UMODL1;C21orf128 -0.55 -8.65 -0.47 5.1e-16 IgG glycosylation; CESC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg02038168 chr22:39784481 NA -0.66 -8.29 -0.45 5.63e-15 Intelligence (multi-trait analysis); CESC trans rs2593957 0.503 rs9821382 chr3:108812154 A/G cg14361641 chr2:70056642 GMCL1 -0.54 -6.17 -0.35 2.57e-9 Colorectal cancer (diet interaction); CESC trans rs17685 0.753 rs1806885 chr7:75785612 T/G cg19862616 chr7:65841803 NCRNA00174 0.85 12.42 0.61 3.15e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg14926445 chr8:58193284 C8orf71 -0.51 -5.52 -0.32 8.28e-8 Developmental language disorder (linguistic errors); CESC cis rs17608059 0.504 rs11656981 chr17:13978777 A/G cg11395062 chr17:14139857 CDRT15 0.57 7.37 0.41 2.12e-12 Temperament; CESC cis rs5753037 0.702 rs5752961 chr22:30188084 C/T cg01021169 chr22:30184971 ASCC2 -0.46 -6.57 -0.37 2.65e-10 Type 1 diabetes; CESC cis rs72945132 0.882 rs60917762 chr11:70211384 C/T cg00319359 chr11:70116639 PPFIA1 0.73 6.99 0.39 2.25e-11 Coronary artery disease; CESC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg02398342 chr17:80708632 TBCD;FN3K 0.44 5.3 0.31 2.39e-7 Glycated hemoglobin levels; CESC cis rs4595586 0.525 rs35089392 chr12:39414547 T/G cg26384229 chr12:38710491 ALG10B 0.61 8.37 0.46 3.29e-15 Morning vs. evening chronotype; CESC cis rs2115630 0.691 rs61322921 chr15:85163638 T/C cg12501888 chr15:85177176 SCAND2 -0.49 -6.54 -0.37 3.07e-10 P wave terminal force; CESC cis rs12497850 0.931 rs6446253 chr3:48911443 C/T cg03060546 chr3:49711283 APEH 0.44 5.5 0.32 8.91e-8 Parkinson's disease; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24415922 chr4:858814 GAK -0.43 -6.5 -0.37 3.92e-10 Gut microbiota (bacterial taxa); CESC cis rs2074038 1.000 rs2074038 chr11:44087989 G/T cg00452199 chr11:44088257 ACCS -0.78 -7.51 -0.42 9.29e-13 IgA nephropathy; CESC cis rs16858210 0.657 rs73177515 chr3:183566825 T/A cg25686905 chr3:183603175 PARL -0.33 -5.83 -0.34 1.62e-8 Menopause (age at onset); CESC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.35 0.31 1.88e-7 Electroencephalogram traits; CESC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg17724175 chr1:150552817 MCL1 0.44 7.24 0.41 4.8e-12 Tonsillectomy; CESC cis rs16867321 0.627 rs1406262 chr2:181585220 A/G cg23363182 chr2:181467187 NA -0.44 -6.8 -0.39 7.09e-11 Obesity; CESC cis rs13102973 0.932 rs6858552 chr4:135864734 C/T cg14419869 chr4:135874104 NA -0.4 -6.31 -0.36 1.15e-9 Subjective well-being; CESC cis rs9399135 0.660 rs4472368 chr6:135274232 A/G cg24558204 chr6:135376177 HBS1L 0.55 7.54 0.42 7.45e-13 Red blood cell count; CESC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg23590916 chr17:43697445 MGC57346 0.65 6.49 0.37 4.28e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs672059 1.000 rs1760624 chr1:183158552 C/A ch.1.3577855R chr1:183094577 LAMC1 0.54 6.97 0.39 2.51e-11 Hypertriglyceridemia; CESC cis rs8067354 0.645 rs2665403 chr17:57889985 G/A cg02344993 chr17:57696989 CLTC 0.56 6.04 0.35 5.31e-9 Hemoglobin concentration; CESC cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg26408565 chr15:76604113 ETFA -0.41 -6.02 -0.35 5.85e-9 Blood metabolite levels; CESC cis rs2979489 0.786 rs2915595 chr8:30402817 A/G cg26383811 chr8:30366931 RBPMS 0.76 9.67 0.51 3.97e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs2000999 0.691 rs11648003 chr16:72052348 A/G cg01557791 chr16:72042693 DHODH -0.56 -5.63 -0.33 4.57e-8 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CESC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.4 0.57 9.4e-25 Alzheimer's disease; CESC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg20243544 chr17:37824526 PNMT -0.46 -5.66 -0.33 3.97e-8 Glomerular filtration rate (creatinine); CESC cis rs3760982 0.585 rs11673534 chr19:44298884 G/A cg11993925 chr19:44307056 LYPD5 0.34 5.85 0.34 1.45e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg03461704 chr1:205818484 PM20D1 0.41 5.12 0.3 5.93e-7 Menarche (age at onset); CESC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg00129232 chr17:37814104 STARD3 0.55 7.17 0.4 7.3e-12 Glomerular filtration rate (creatinine); CESC cis rs854765 0.647 rs2974998 chr17:17995619 A/G cg04398451 chr17:18023971 MYO15A -0.76 -11.24 -0.57 3.24e-24 Total body bone mineral density; CESC cis rs28830936 0.966 rs1918310 chr15:42065253 A/C cg17847044 chr15:42102381 MAPKBP1 -0.35 -5.12 -0.3 5.91e-7 Diastolic blood pressure; CESC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg02725872 chr8:58115012 NA -0.45 -7.05 -0.4 1.51e-11 Developmental language disorder (linguistic errors); CESC cis rs208520 0.754 rs12204635 chr6:66740779 C/A cg07460842 chr6:66804631 NA 0.97 12.84 0.62 1.11e-29 Exhaled nitric oxide output; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg05847233 chr18:12374049 AFG3L2 0.44 6.46 0.37 4.98e-10 Cleft plate (environmental tobacco smoke interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18704218 chr5:33162408 NA -0.57 -6.58 -0.37 2.44e-10 Gut microbiome composition (summer); CESC cis rs1595825 0.891 rs16866940 chr2:198509058 C/T cg10820045 chr2:198174542 NA 0.41 5.14 0.3 5.33e-7 Ulcerative colitis; CESC cis rs72945132 1.000 rs7938912 chr11:70114885 C/T cg14191688 chr11:70257035 CTTN 0.41 5.04 0.3 8.65e-7 Coronary artery disease; CESC cis rs854765 0.663 rs1052299 chr17:17750419 A/G cg09796270 chr17:17721594 SREBF1 -0.45 -6.47 -0.37 4.64e-10 Total body bone mineral density; CESC cis rs854765 0.929 rs854766 chr17:18012775 A/G cg16928487 chr17:17741425 SREBF1 -0.56 -9.13 -0.49 1.75e-17 Total body bone mineral density; CESC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg16132339 chr22:24313637 DDTL;DDT 0.4 6.14 0.35 3.07e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7659604 0.791 rs57316471 chr4:122663939 A/G cg19748678 chr4:122722346 EXOSC9 0.54 6.2 0.36 2.17e-9 Type 2 diabetes; CESC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg04944784 chr2:26401820 FAM59B -0.81 -9.84 -0.52 1.1e-19 Gut microbiome composition (summer); CESC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg18230493 chr5:56204884 C5orf35 -0.62 -8.3 -0.45 5.39e-15 Initial pursuit acceleration; CESC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.92 10.05 0.53 2.44e-20 Platelet count; CESC cis rs684232 0.623 rs12601935 chr17:519325 G/A cg15660573 chr17:549704 VPS53 -0.81 -11.88 -0.59 2.24e-26 Prostate cancer; CESC cis rs11650494 0.710 rs11654557 chr17:47390136 A/G cg08112188 chr17:47440006 ZNF652 1.31 8.51 0.46 1.31e-15 Prostate cancer; CESC cis rs11122272 0.667 rs2244992 chr1:231537220 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -7.44 -0.42 1.38e-12 Hemoglobin concentration; CESC cis rs116095464 0.614 rs28736753 chr5:274081 G/A cg22857025 chr5:266934 NA -1.29 -17.75 -0.74 5.57e-47 Breast cancer; CESC cis rs7937682 1.000 rs12363179 chr11:111568091 G/A cg09085632 chr11:111637200 PPP2R1B 1.03 14.07 0.65 5.86e-34 Primary sclerosing cholangitis; CESC cis rs1707322 0.721 rs61784796 chr1:46163256 A/G cg03146154 chr1:46216737 IPP 0.82 11.54 0.58 3.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs738322 0.870 rs5750558 chr22:38582497 G/A cg17652424 chr22:38574118 PLA2G6 0.31 5.55 0.32 6.75e-8 Cutaneous nevi; CESC cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg25427524 chr10:38739819 LOC399744 -0.67 -9.8 -0.52 1.46e-19 Extrinsic epigenetic age acceleration; CESC cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg10523679 chr1:76189770 ACADM 0.71 8.23 0.45 8.39e-15 Blood metabolite levels;Acylcarnitine levels; CESC trans rs7246657 0.943 rs9676967 chr19:37928089 G/C cg24637308 chr11:6592297 DNHD1 0.54 6.34 0.36 1.01e-9 Coronary artery calcification; CESC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg18404041 chr3:52824283 ITIH1 -0.41 -6.83 -0.39 5.93e-11 Bipolar disorder; CESC cis rs1048238 0.506 rs848194 chr1:16285342 G/A cg21385522 chr1:16154831 NA -0.45 -5.59 -0.32 5.76e-8 Systolic blood pressure; CESC cis rs7107174 0.748 rs7105835 chr11:78075725 T/C cg02023728 chr11:77925099 USP35 0.39 5.57 0.32 6.35e-8 Testicular germ cell tumor; CESC cis rs1559088 0.847 rs6510348 chr19:33601946 G/A cg27124370 chr19:33622961 WDR88 0.45 5.86 0.34 1.34e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg17971929 chr21:40555470 PSMG1 0.52 6.79 0.38 7.35e-11 Menarche (age at onset); CESC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg06481639 chr22:41940642 POLR3H -0.63 -6.6 -0.38 2.22e-10 Vitiligo; CESC cis rs7937682 0.883 rs486038 chr11:111465963 A/C cg09085632 chr11:111637200 PPP2R1B -0.9 -12.87 -0.62 9.33e-30 Primary sclerosing cholangitis; CESC cis rs7666738 0.576 rs7660951 chr4:98651581 T/A cg05340658 chr4:99064831 C4orf37 0.6 7.36 0.41 2.35e-12 Colonoscopy-negative controls vs population controls; CESC cis rs4803468 1.000 rs10413735 chr19:41921071 C/T cg14132834 chr19:41945861 ATP5SL -0.68 -8.41 -0.46 2.55e-15 Height; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13094511 chr2:99061177 INPP4A -0.47 -6.21 -0.36 2.09e-9 Ulcerative colitis; CESC cis rs3749237 0.595 rs4855877 chr3:49448527 T/C cg03060546 chr3:49711283 APEH 0.73 10.94 0.56 3.04e-23 Resting heart rate; CESC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.55 -6.96 -0.39 2.68e-11 Prudent dietary pattern; CESC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Parkinson's disease; CESC cis rs1443512 0.755 rs1373160 chr12:54340383 A/G cg12374095 chr12:54320830 NA -0.46 -6.08 -0.35 4.2e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs929354 0.772 rs933344 chr7:157011265 A/T cg05182265 chr7:156933206 UBE3C -0.5 -7.39 -0.41 1.88e-12 Body mass index; CESC cis rs477692 1.000 rs7475154 chr10:131440584 C/T cg05714579 chr10:131428358 MGMT -0.51 -6.82 -0.39 6.11e-11 Response to temozolomide; CESC cis rs858239 0.600 rs2014768 chr7:23122440 C/A cg23682824 chr7:23144976 KLHL7 0.55 7.63 0.42 4.21e-13 Cerebrospinal fluid biomarker levels; CESC cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg18876405 chr7:65276391 NA 0.49 5.38 0.31 1.63e-7 Aortic root size; CESC cis rs2635047 0.756 rs34939493 chr18:44795621 G/T cg24371990 chr18:44770781 NA 0.42 6.59 0.38 2.37e-10 Educational attainment; CESC cis rs10256972 0.528 rs7784607 chr7:1178694 A/G cg16145915 chr7:1198662 ZFAND2A -0.63 -9.69 -0.51 3.3e-19 Longevity;Endometriosis; CESC cis rs72781680 0.898 rs56413706 chr2:24086961 G/A cg08917208 chr2:24149416 ATAD2B 1.11 10.18 0.53 9.57e-21 Lymphocyte counts; CESC cis rs116095464 0.558 rs1971229 chr5:268187 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.49 0.32 9.44e-8 Breast cancer; CESC cis rs2733201 1.000 rs2114420 chr15:44312583 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.65 -5.93 -0.34 9.58e-9 Lipoprotein phospholipase A2 activity in cardiovascular disease; CESC trans rs11098499 0.954 rs4309825 chr4:120314881 C/T cg25214090 chr10:38739885 LOC399744 -0.61 -8.37 -0.46 3.42e-15 Corneal astigmatism; CESC cis rs1538970 0.962 rs9429158 chr1:45821393 A/G cg05343316 chr1:45956843 TESK2 0.8 11.16 0.57 5.81e-24 Platelet count; CESC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg11890956 chr21:40555474 PSMG1 -0.91 -14.27 -0.66 1.14e-34 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01626569 chr16:20911881 LYRM1;DCUN1D3 0.59 7.02 0.4 1.84e-11 Gut microbiome composition (summer); CESC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg05535760 chr7:792225 HEATR2 1.0 11.28 0.57 2.3e-24 Cerebrospinal P-tau181p levels; CESC cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg25019033 chr10:957182 NA -0.65 -6.53 -0.37 3.33e-10 Eosinophil percentage of granulocytes; CESC trans rs4950322 0.542 rs3766519 chr1:146686372 C/T cg04954894 chr8:38089920 DDHD2 -0.62 -6.34 -0.36 9.73e-10 Protein quantitative trait loci; CESC cis rs2243480 1.000 rs6974723 chr7:65637939 C/T cg18252515 chr7:66147081 NA 1.36 13.62 0.64 2.25e-32 Diabetic kidney disease; CESC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg03060546 chr3:49711283 APEH 0.55 6.78 0.38 7.91e-11 Parkinson's disease; CESC cis rs7727544 0.684 rs274560 chr5:131719450 T/C cg07395648 chr5:131743802 NA 0.44 5.93 0.34 9.45e-9 Blood metabolite levels; CESC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg11890956 chr21:40555474 PSMG1 0.97 16.58 0.71 7.37e-43 Cognitive function; CESC cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg24308560 chr3:49941425 MST1R -0.65 -9.57 -0.51 7.85e-19 Intelligence (multi-trait analysis); CESC cis rs2832191 0.791 rs2832181 chr21:30481371 G/T cg24692254 chr21:30365293 RNF160 -0.81 -12.75 -0.62 2.33e-29 Dental caries; CESC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg13206674 chr6:150067644 NUP43 0.41 5.78 0.33 2.05e-8 Lung cancer; CESC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg17971929 chr21:40555470 PSMG1 -0.6 -7.82 -0.43 1.24e-13 Menarche (age at onset); CESC cis rs6831352 0.734 rs1154400 chr4:100010010 C/T cg12011299 chr4:100065546 ADH4 0.58 6.97 0.39 2.49e-11 Alcohol dependence; CESC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg11890956 chr21:40555474 PSMG1 1.2 23.14 0.82 1.44e-65 Cognitive function; CESC cis rs72781680 1.000 rs72781648 chr2:24210333 T/C cg20701182 chr2:24300061 SF3B14 0.63 5.58 0.32 6.04e-8 Lymphocyte counts; CESC cis rs6502050 0.799 rs4132775 chr17:80155412 C/T cg23985595 chr17:80112537 CCDC57 -0.4 -6.42 -0.37 6.32e-10 Life satisfaction; CESC cis rs9583531 0.657 rs7337126 chr13:111376788 A/G cg24331049 chr13:111365604 ING1 0.73 10.44 0.54 1.33e-21 Coronary artery disease; CESC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.61 7.93 0.44 6.03e-14 Menopause (age at onset); CESC cis rs300703 0.935 rs4241316 chr2:252197 A/G cg21211680 chr2:198530 NA -0.89 -7.74 -0.43 2.16e-13 Blood protein levels; CESC cis rs11608355 0.545 rs12819658 chr12:109907670 A/T cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs3825932 0.778 rs11072817 chr15:79236815 G/A cg25744700 chr15:79237217 CTSH 0.51 6.87 0.39 4.7e-11 Type 1 diabetes; CESC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg18032046 chr6:28092343 ZSCAN16 -0.58 -6.75 -0.38 9.45e-11 Depression; CESC cis rs9910055 0.530 rs8072954 chr17:42294722 G/A cg13607699 chr17:42295918 UBTF 0.82 12.63 0.61 5.85e-29 Total body bone mineral density; CESC cis rs6495122 0.532 rs2472304 chr15:75044238 G/A cg14664628 chr15:75095509 CSK -0.61 -7.96 -0.44 5.11e-14 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CESC cis rs9291683 0.507 rs6849273 chr4:10021595 C/T cg11266682 chr4:10021025 SLC2A9 0.66 13.27 0.63 3.6e-31 Bone mineral density; CESC cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.46 -8.18 -0.45 1.23e-14 Birth weight; CESC cis rs1003719 0.715 rs2835646 chr21:38546574 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -7.98 -0.44 4.49e-14 Eye color traits; CESC cis rs2710642 0.721 rs58305080 chr2:62895132 C/T cg17519650 chr2:63277830 OTX1 0.57 6.78 0.38 7.7e-11 LDL cholesterol levels;LDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04153114 chr8:99129570 POP1;HRSP12 0.59 7.24 0.41 4.85e-12 Gut microbiome composition (summer); CESC cis rs7267979 0.714 rs3787082 chr20:25235736 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.71 11.36 0.57 1.22e-24 Liver enzyme levels (alkaline phosphatase); CESC cis rs59918340 0.764 rs10107024 chr8:142227592 T/C cg16341495 chr8:142228727 SLC45A4 -0.44 -5.32 -0.31 2.22e-7 Immature fraction of reticulocytes; CESC cis rs2832191 0.716 rs8132085 chr21:30501389 G/T cg08807101 chr21:30365312 RNF160 -0.83 -11.51 -0.58 3.87e-25 Dental caries; CESC cis rs7116495 0.609 rs73543612 chr11:71820350 C/T cg10381502 chr11:71823885 C11orf51 1.05 6.51 0.37 3.78e-10 Severe influenza A (H1N1) infection; CESC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 10.29 0.53 4.17e-21 Prudent dietary pattern; CESC cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg05340658 chr4:99064831 C4orf37 0.8 12.44 0.61 2.83e-28 Colonoscopy-negative controls vs population controls; CESC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg27297192 chr10:134578999 INPP5A 0.4 5.27 0.31 2.77e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs561341 0.769 rs559228 chr17:30294527 T/C cg19193384 chr17:30244184 NA -0.68 -6.43 -0.37 5.9e-10 Hip circumference adjusted for BMI; CESC cis rs7666738 0.830 rs10007261 chr4:98926155 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.59 0.32 5.78e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2635047 0.682 rs1980055 chr18:44792636 G/A cg24371990 chr18:44770781 NA 0.39 6.26 0.36 1.5e-9 Educational attainment; CESC cis rs1707322 0.682 rs28508523 chr1:46189625 G/A cg03146154 chr1:46216737 IPP 0.76 10.9 0.56 4.26e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg25332325 chr10:71906362 TYSND1 -0.44 -6.18 -0.35 2.36e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg11226328 chr1:29213367 EPB41 0.44 6.16 0.35 2.62e-9 Systemic lupus erythematosus; CESC cis rs754466 0.580 rs11002301 chr10:79574078 G/A cg17075019 chr10:79541650 NA -0.87 -13.71 -0.64 1.06e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9611565 0.649 rs202625 chr22:41827082 G/A cg06634786 chr22:41940651 POLR3H 0.71 7.08 0.4 1.28e-11 Vitiligo; CESC cis rs35110281 0.633 rs4819292 chr21:45125223 A/G cg21573476 chr21:45109991 RRP1B -0.57 -8.43 -0.46 2.2e-15 Mean corpuscular volume; CESC cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg10578991 chr7:12443926 VWDE -0.51 -5.67 -0.33 3.75e-8 Coronary artery disease; CESC cis rs644799 1.000 rs473155 chr11:95596873 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.5 5.93 0.34 9.45e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs1215050 0.791 rs2865942 chr4:98737709 G/C cg05340658 chr4:99064831 C4orf37 0.5 6.34 0.36 9.81e-10 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.97 9.35 0.5 3.75e-18 Platelet count; CESC cis rs10463316 0.862 rs7720582 chr5:150776502 C/T cg03212797 chr5:150827313 SLC36A1 0.44 5.8 0.34 1.84e-8 Metabolite levels (Pyroglutamine); CESC cis rs9863 0.794 rs7978610 chr12:124468572 C/G cg17562584 chr12:124393655 DNAH10 -0.31 -5.18 -0.3 4.39e-7 White blood cell count; CESC cis rs427394 0.582 rs274662 chr5:6704860 G/A cg10857441 chr5:6722123 POLS -0.42 -5.07 -0.3 7.61e-7 Menopause (age at onset); CESC cis rs7824557 0.614 rs2736277 chr8:11218893 C/T cg21775007 chr8:11205619 TDH -0.56 -9.24 -0.49 8.25e-18 Retinal vascular caliber; CESC cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg12365402 chr11:9010492 NRIP3 0.41 7.09 0.4 1.18e-11 Hemoglobin concentration; CESC cis rs873946 0.564 rs12242672 chr10:134555609 A/T cg26818010 chr10:134567672 INPP5A -0.79 -9.67 -0.51 3.74e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg13126279 chr21:47581558 C21orf56 0.49 6.68 0.38 1.36e-10 Testicular germ cell tumor; CESC cis rs116095464 0.558 rs6881920 chr5:222411 T/C cg22857025 chr5:266934 NA -1.27 -18.89 -0.76 5.51e-51 Breast cancer; CESC cis rs9291683 0.609 rs12500810 chr4:10031068 G/A cg11266682 chr4:10021025 SLC2A9 0.7 14.13 0.66 3.49e-34 Bone mineral density; CESC cis rs9467711 0.720 rs7749823 chr6:26158079 A/C cg21479132 chr6:26055353 NA 0.65 6.51 0.37 3.68e-10 Autism spectrum disorder or schizophrenia; CESC cis rs4523957 0.522 rs8081921 chr17:2021490 C/A cg16513277 chr17:2031491 SMG6 -0.71 -10.1 -0.53 1.62e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg18765753 chr7:1198926 ZFAND2A -0.44 -6.53 -0.37 3.41e-10 Longevity;Endometriosis; CESC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg11859384 chr17:80120422 CCDC57 -0.39 -5.34 -0.31 1.98e-7 Life satisfaction; CESC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg11644478 chr21:40555479 PSMG1 0.8 11.84 0.59 3.02e-26 Cognitive function; CESC cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg15595755 chr5:1867978 NA 0.51 8.17 0.45 1.29e-14 Cardiovascular disease risk factors; CESC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.45 -0.37 5.27e-10 Electroencephalogram traits; CESC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg06808227 chr14:105710500 BRF1 -0.55 -7.06 -0.4 1.42e-11 Mean platelet volume;Platelet distribution width; CESC cis rs863345 0.604 rs7533071 chr1:158504479 T/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs9549367 0.789 rs3861720 chr13:113906097 A/G cg00898013 chr13:113819073 PROZ -0.53 -7.21 -0.41 5.74e-12 Platelet distribution width; CESC cis rs72720396 0.789 rs12022460 chr1:91202257 A/G cg13456504 chr1:91191583 NA -0.48 -6.93 -0.39 3.23e-11 Morning vs. evening chronotype;Chronotype; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10089324 chr1:51984752 EPS15 0.51 6.61 0.38 2.15e-10 Gut microbiota (bacterial taxa); CESC cis rs4820539 1.000 rs885964 chr22:23461003 G/C cg14186256 chr22:23484241 RTDR1 0.83 15.02 0.68 2.7e-37 Bone mineral density; CESC cis rs8072100 0.967 rs4289035 chr17:45707211 C/T cg08085267 chr17:45401833 C17orf57 -0.39 -5.03 -0.3 8.86e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs1030877 0.889 rs2576746 chr2:105909559 G/A cg02079111 chr2:105885981 TGFBRAP1 0.64 10.21 0.53 7.17e-21 Obesity-related traits; CESC cis rs8062405 0.688 rs3924376 chr16:28925978 T/C cg08761264 chr16:28874980 SH2B1 0.43 5.09 0.3 6.95e-7 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs1538970 0.924 rs11211117 chr1:45930246 C/T cg24296786 chr1:45957014 TESK2 -0.46 -5.17 -0.3 4.58e-7 Platelet count; CESC cis rs6060717 0.536 rs6060683 chr20:34507921 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -6.96 -0.39 2.63e-11 Hip circumference adjusted for BMI; CESC cis rs3750965 0.959 rs2253658 chr11:68856804 C/G cg01403660 chr11:68851641 TPCN2 0.4 5.21 0.3 3.74e-7 Hair color; CESC cis rs644799 1.000 rs505220 chr11:95563228 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.76 0.38 8.51e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9300255 0.602 rs1616181 chr12:123619856 T/A cg05973401 chr12:123451056 ABCB9 0.53 5.92 0.34 9.71e-9 Neutrophil percentage of white cells; CESC cis rs7085104 0.632 rs6162 chr10:104596981 G/A cg04362960 chr10:104952993 NT5C2 0.51 6.76 0.38 8.62e-11 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs7223966 1.000 rs11658740 chr17:61751069 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.45 -5.2 -0.3 3.92e-7 Hip circumference adjusted for BMI;Body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05112967 chr7:63353492 NA 0.43 6.03 0.35 5.54e-9 Fibrinogen levels; CESC cis rs12142240 0.660 rs6679080 chr1:46819779 A/T cg10495392 chr1:46806563 NSUN4 0.57 6.27 0.36 1.47e-9 Menopause (age at onset); CESC cis rs1642645 0.793 rs6695748 chr1:42481707 G/T cg16685388 chr1:42384056 HIVEP3 0.38 5.68 0.33 3.47e-8 Left ventricular obstructive tract defect (maternal effect); CESC cis rs1008375 1.000 rs6854733 chr4:17640526 C/T cg02297831 chr4:17616191 MED28 0.53 6.71 0.38 1.2e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2034088 0.965 rs11651340 chr17:425099 A/C cg13332499 chr17:408570 NA -0.42 -6.6 -0.38 2.17e-10 Hip circumference adjusted for BMI; CESC cis rs1057239 0.739 rs1014554 chr1:175133626 A/G cg00321850 chr1:175162397 KIAA0040 0.44 6.32 0.36 1.11e-9 Diastolic blood pressure; CESC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg26119090 chr2:26468346 HADHA;HADHB -1.1 -12.68 -0.61 4e-29 Gut microbiome composition (summer); CESC cis rs6693567 0.565 rs696615 chr1:150338988 A/C cg09579323 chr1:150459698 TARS2 0.48 6.09 0.35 4.04e-9 Migraine; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23329303 chr11:46638664 KIAA0652;HARBI1 0.73 7.94 0.44 5.66e-14 Gut microbiome composition (summer); CESC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg08499158 chr17:42289980 UBTF -0.5 -6.3 -0.36 1.21e-9 Total body bone mineral density; CESC cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.53 0.32 7.62e-8 Personality dimensions; CESC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg03538708 chr1:25844672 NA -0.36 -5.29 -0.31 2.62e-7 Erythrocyte sedimentation rate; CESC trans rs4578769 0.569 rs12955131 chr18:20480387 A/G cg03552156 chr3:187463844 BCL6 -0.44 -6.12 -0.35 3.28e-9 Eosinophil percentage of white cells; CESC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg06634786 chr22:41940651 POLR3H 0.7 7.01 0.4 1.99e-11 Vitiligo; CESC cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg04166393 chr7:2884313 GNA12 0.39 5.22 0.31 3.68e-7 Height; CESC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg25838465 chr1:92012736 NA -0.6 -8.69 -0.47 3.96e-16 Breast cancer; CESC cis rs6062302 0.522 rs4809312 chr20:62234240 C/T cg06363034 chr20:62225388 GMEB2 -0.51 -6.58 -0.37 2.52e-10 Glioblastoma; CESC cis rs27434 0.605 rs2351012 chr5:96191747 A/G cg16492584 chr5:96139282 ERAP1 -0.54 -6.5 -0.37 3.86e-10 Ankylosing spondylitis; CESC cis rs7692995 1.000 rs7668933 chr4:17988141 A/G cg08925142 chr4:18023851 LCORL -0.44 -5.1 -0.3 6.61e-7 Height; CESC cis rs6432018 0.927 rs6734469 chr2:9735900 G/A cg23886495 chr2:9695866 ADAM17 0.43 5.08 0.3 7.21e-7 Heart rate variability traits; CESC cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg14440974 chr22:39074834 NA -0.42 -5.83 -0.34 1.62e-8 Menopause (age at onset); CESC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg02450064 chr17:40260053 DHX58 0.35 5.13 0.3 5.68e-7 Fibrinogen levels; CESC cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg24308560 chr3:49941425 MST1R 0.62 9.16 0.49 1.45e-17 Intelligence (multi-trait analysis); CESC cis rs10870270 0.956 rs7904594 chr10:133734671 C/T cg17892150 chr10:133769511 PPP2R2D -0.86 -12.69 -0.61 3.83e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg19774624 chr17:42201019 HDAC5 0.6 7.88 0.44 8.58e-14 Total body bone mineral density; CESC trans rs747782 0.528 rs11039669 chr11:48328818 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.31 0.36 1.19e-9 Intraocular pressure; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25327233 chr10:99894913 C10orf28 -0.44 -6.35 -0.36 9.38e-10 Ulcerative colitis; CESC cis rs9467773 0.620 rs2504567 chr6:26662920 C/G cg24633756 chr6:26577808 NA 0.37 5.5 0.32 8.86e-8 Intelligence (multi-trait analysis); CESC cis rs3820068 0.608 rs12091326 chr1:16048005 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.75 0.33 2.52e-8 Systolic blood pressure; CESC cis rs15676 0.679 rs6478853 chr9:131588813 C/G cg00228799 chr9:131580591 ENDOG -0.55 -7.04 -0.4 1.67e-11 Blood metabolite levels; CESC cis rs9487051 0.676 rs7753697 chr6:109593292 A/G cg21918786 chr6:109611834 NA -0.37 -5.41 -0.32 1.39e-7 Reticulocyte fraction of red cells; CESC cis rs1559088 0.847 rs3786933 chr19:33602881 C/T cg17764715 chr19:33622953 WDR88 0.48 6.2 0.36 2.2e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs3106136 0.609 rs28696050 chr4:95136630 G/C cg11021082 chr4:95130006 SMARCAD1 -0.47 -6.49 -0.37 4.28e-10 Capecitabine sensitivity; CESC cis rs10129255 0.518 rs8009612 chr14:107185749 G/T cg07958169 chr14:107095056 NA -0.55 -8.74 -0.47 2.74e-16 Kawasaki disease; CESC cis rs3741151 0.773 rs73542960 chr11:73115946 T/C cg17517138 chr11:73019481 ARHGEF17 0.98 7.16 0.4 8.01e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.03 -0.49 3.55e-17 Developmental language disorder (linguistic errors); CESC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg26441486 chr22:50317300 CRELD2 0.42 5.24 0.31 3.33e-7 Schizophrenia; CESC cis rs4132509 0.553 rs12140414 chr1:243674387 A/G cg21452805 chr1:244014465 NA 0.49 5.71 0.33 2.99e-8 RR interval (heart rate); CESC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.72 0.38 1.09e-10 Bipolar disorder; CESC cis rs992157 0.798 rs10932772 chr2:219177148 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.7 9.5 0.5 1.34e-18 Colorectal cancer; CESC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg23048001 chr7:2026167 MAD1L1 0.47 6.11 0.35 3.5e-9 Bipolar disorder and schizophrenia; CESC trans rs4234798 0.546 rs4689667 chr4:7249188 A/T cg05306006 chr2:210867127 RPE 0.5 6.18 0.35 2.44e-9 Insulin-like growth factors; CESC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20069020 chr7:108166782 PNPLA8 0.47 6.42 0.37 6.44e-10 Intelligence (multi-trait analysis); CESC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg06001716 chr17:41278141 BRCA1;NBR2 0.38 5.34 0.31 2.03e-7 Menopause (age at onset); CESC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg04369109 chr6:150039330 LATS1 -0.41 -5.54 -0.32 7.16e-8 Lung cancer; CESC cis rs2806561 0.780 rs12409321 chr1:23398065 C/T cg12483005 chr1:23474871 LUZP1 -0.34 -5.3 -0.31 2.42e-7 Height; CESC cis rs11098499 0.821 rs28665282 chr4:120384186 C/T cg09307838 chr4:120376055 NA 0.95 13.79 0.65 5.71e-33 Corneal astigmatism; CESC cis rs7191439 0.858 rs8050715 chr16:88780923 C/G cg27087555 chr16:88793112 FAM38A -1.13 -9.84 -0.52 1.13e-19 Plateletcrit; CESC cis rs17376456 0.877 rs7701011 chr5:93311456 G/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.61 5.33 0.31 2.15e-7 Diabetic retinopathy; CESC cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg03467027 chr4:99064603 C4orf37 0.48 5.98 0.35 7.05e-9 Colonoscopy-negative controls vs population controls; CESC cis rs96067 0.772 rs2231318 chr1:36602943 C/T cg24686825 chr1:36642396 MAP7D1 -0.45 -5.12 -0.3 5.86e-7 Corneal structure; CESC cis rs1538970 0.962 rs2153608 chr1:45813941 C/T cg05343316 chr1:45956843 TESK2 -0.77 -10.58 -0.55 4.6e-22 Platelet count; CESC trans rs864643 0.773 rs11129837 chr3:39589963 A/G cg03273382 chr1:205782342 SLC41A1 0.47 6.03 0.35 5.38e-9 Attention deficit hyperactivity disorder; CESC trans rs7980799 0.682 rs61927702 chr12:33631695 A/G cg26384229 chr12:38710491 ALG10B -0.56 -7.98 -0.44 4.41e-14 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs4589502 0.925 rs4259997 chr15:67153310 A/G cg12317470 chr15:67143691 NA -0.8 -9.93 -0.52 5.86e-20 Lung cancer (smoking interaction); CESC cis rs28374715 0.681 rs28712264 chr15:41588797 T/C cg18705301 chr15:41695430 NDUFAF1 -1.0 -14.55 -0.67 1.2e-35 Ulcerative colitis; CESC cis rs6831352 0.819 rs896992 chr4:100002372 C/T cg12011299 chr4:100065546 ADH4 0.64 8.17 0.45 1.29e-14 Alcohol dependence; CESC cis rs4728302 0.869 rs889825 chr7:133596227 A/G cg10665199 chr7:133106180 EXOC4 0.4 5.57 0.32 6.32e-8 Intelligence;Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg22767166 chr8:49833685 SNAI2 0.37 7.24 0.41 4.74e-12 Gambling; CESC cis rs9486715 0.867 rs12207471 chr6:96963782 A/G cg06623918 chr6:96969491 KIAA0776 0.93 14.38 0.66 4.81e-35 Headache; CESC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg13206674 chr6:150067644 NUP43 0.42 5.89 0.34 1.19e-8 Lung cancer; CESC trans rs9850225 0.764 rs6780379 chr3:80560525 A/G cg20909656 chr7:14029360 ETV1 -0.42 -6.13 -0.35 3.23e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs10411262 0.935 rs314661 chr19:47172473 C/T cg13467550 chr19:47212573 PRKD2 0.32 5.29 0.31 2.59e-7 Tonsillectomy; CESC cis rs6831256 0.505 rs11947277 chr4:3473751 C/T cg04102620 chr4:3473595 DOK7 0.36 5.22 0.31 3.69e-7 LDL cholesterol;Triglyceride levels;Triglycerides;Cholesterol, total; CESC cis rs7296418 0.630 rs7974099 chr12:123771475 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -5.31 -0.31 2.36e-7 Platelet count; CESC cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg02297831 chr4:17616191 MED28 0.6 7.51 0.42 9.14e-13 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9457247 1.000 rs400063 chr6:167386592 C/T cg25258033 chr6:167368657 RNASET2 0.4 6.06 0.35 4.59e-9 Crohn's disease; CESC cis rs6952809 0.590 rs1468337 chr7:2432211 C/T cg25507518 chr7:2405875 EIF3B 0.48 5.08 0.3 7.23e-7 Multiple sclerosis; CESC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg23758822 chr17:41437982 NA 1.02 15.64 0.69 1.65e-39 Menopause (age at onset); CESC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg06481639 chr22:41940642 POLR3H 0.6 5.95 0.34 8.27e-9 Vitiligo; CESC cis rs7216064 1.000 rs7208663 chr17:65885171 T/C cg12091567 chr17:66097778 LOC651250 -0.8 -9.08 -0.49 2.65e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg24562669 chr7:97807699 LMTK2 0.51 7.54 0.42 7.55e-13 Prostate cancer (SNP x SNP interaction); CESC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.45 0.42 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4563143 0.514 rs73029076 chr19:29292032 G/T cg14983838 chr19:29218262 NA 0.49 5.47 0.32 1.02e-7 Methadone dose in opioid dependence; CESC cis rs9929218 0.954 rs12924033 chr16:68822599 G/A cg02972257 chr16:68554789 NA 0.44 5.18 0.3 4.35e-7 Colorectal cancer; CESC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg08470875 chr2:26401718 FAM59B -0.47 -5.22 -0.31 3.59e-7 Gut microbiome composition (summer); CESC cis rs748404 0.631 rs6493083 chr15:43637985 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.93 0.44 6.29e-14 Lung cancer; CESC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg10664184 chr19:17420304 DDA1 0.44 5.18 0.3 4.35e-7 Systemic lupus erythematosus; CESC cis rs62064224 0.675 rs12150479 chr17:30636200 T/A cg18200150 chr17:30822561 MYO1D 0.38 5.14 0.3 5.46e-7 Schizophrenia; CESC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg05863683 chr7:1912471 MAD1L1 0.42 6.24 0.36 1.69e-9 Bipolar disorder and schizophrenia; CESC cis rs1691799 0.899 rs1168307 chr12:66739539 A/G cg16791601 chr12:66731901 HELB -0.8 -14.41 -0.66 3.8e-35 White blood cell count (basophil); CESC cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg26597838 chr10:835615 NA 0.92 10.01 0.52 3.13e-20 Eosinophil percentage of granulocytes; CESC cis rs265548 0.646 rs36692 chr19:17906839 C/T cg16744531 chr19:17905626 B3GNT3 0.58 8.23 0.45 8.43e-15 Tumor biomarkers; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg10727759 chr12:50017361 PRPF40B -0.43 -6.24 -0.36 1.69e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs853679 0.546 rs35744819 chr6:28318331 G/T cg01620082 chr3:125678407 NA -0.81 -6.37 -0.36 8.26e-10 Depression; CESC trans rs997295 0.570 rs737226 chr15:67840773 T/C cg05081167 chr6:156967138 NA 0.27 6.09 0.35 3.87e-9 Motion sickness; CESC cis rs11718455 0.960 rs3843373 chr3:44011053 C/T cg08738300 chr3:44038990 NA -0.45 -5.64 -0.33 4.43e-8 Coronary artery disease; CESC cis rs11098499 0.954 rs67265404 chr4:120359270 C/T cg24375607 chr4:120327624 NA 0.48 5.81 0.34 1.74e-8 Corneal astigmatism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23490074 chr19:30433024 C19orf2 0.44 6.02 0.35 5.92e-9 Gut microbiota (bacterial taxa); CESC cis rs2276314 0.857 rs62101379 chr18:33584902 G/A cg05985134 chr18:33552581 C18orf21 0.61 7.05 0.4 1.55e-11 Endometriosis;Drug-induced torsades de pointes; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg23852354 chr12:47630075 FAM113B 0.45 6.52 0.37 3.56e-10 Thyroid stimulating hormone; CESC cis rs9847710 0.524 rs11712910 chr3:53094194 C/A cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.34 -5.3 -0.31 2.47e-7 Ulcerative colitis; CESC cis rs9399135 0.933 rs9389262 chr6:135376409 G/T cg22676075 chr6:135203613 NA 0.52 7.31 0.41 3.2e-12 Red blood cell count; CESC cis rs2963155 0.518 rs72801029 chr5:142625806 T/C cg17617527 chr5:142782415 NR3C1 0.81 6.37 0.36 8.42e-10 Breast cancer; CESC cis rs9309473 1.000 rs10184268 chr2:73627044 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -6.34 -0.36 9.83e-10 Metabolite levels; CESC cis rs6493487 0.547 rs2414053 chr15:51129924 T/C cg02338191 chr15:51200825 AP4E1 0.51 5.17 0.3 4.58e-7 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1878931 0.582 rs9937267 chr16:3421073 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.71 8.83 0.48 1.51e-16 Body mass index (adult); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg02250680 chr11:58346542 LPXN;ZFP91-CNTF;ZFP91 -0.42 -6.38 -0.36 7.81e-10 Gambling; CESC cis rs6496667 0.779 rs16944518 chr15:91035084 A/C cg13834112 chr15:90361639 NA 0.38 5.09 0.3 6.82e-7 Rheumatoid arthritis; CESC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.753 rs1527520 chr4:98929164 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.2 0.6 1.81e-27 Colonoscopy-negative controls vs population controls; CESC cis rs12474201 0.832 rs11695058 chr2:46978349 A/G cg06386533 chr2:46925753 SOCS5 0.78 10.51 0.54 8.14e-22 Height; CESC cis rs938554 0.784 rs7439210 chr4:9971749 C/G cg00071950 chr4:10020882 SLC2A9 -0.48 -5.76 -0.33 2.32e-8 Blood metabolite levels; CESC cis rs61524473 1 rs61524473 chr15:45646283 T/C cg21132104 chr15:45694354 SPATA5L1 0.84 11.4 0.57 9.5e-25 Metabolite levels (small molecules and protein measures); CESC trans rs11039798 0.588 rs11039807 chr11:48549391 T/A cg03929089 chr4:120376271 NA 0.6 6.03 0.35 5.36e-9 Axial length; CESC cis rs4974559 0.947 rs10006381 chr4:1359309 C/T cg02980000 chr4:1222292 CTBP1 0.66 5.97 0.34 7.7e-9 Systolic blood pressure; CESC cis rs8103278 1.000 rs7252126 chr19:46302374 T/A cg11657440 chr19:46296263 DMWD -0.59 -7.25 -0.41 4.69e-12 Coronary artery disease; CESC cis rs116095464 0.558 rs10057674 chr5:266813 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.86e-15 Breast cancer; CESC cis rs2979489 0.533 rs62505279 chr8:30447069 C/T cg26383811 chr8:30366931 RBPMS -0.66 -7.76 -0.43 1.88e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CESC cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg02297831 chr4:17616191 MED28 0.44 5.4 0.32 1.45e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9814567 1.000 rs11928499 chr3:134232350 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 5.93 0.34 9.22e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7208859 0.673 rs55904046 chr17:29215391 G/A cg19761014 chr17:28927070 LRRC37B2 0.73 5.79 0.34 1.95e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg11644478 chr21:40555479 PSMG1 -0.85 -12.67 -0.61 4.53e-29 Cognitive function; CESC cis rs11098499 0.863 rs6835635 chr4:120458867 A/G cg09307838 chr4:120376055 NA 0.9 12.3 0.6 7.96e-28 Corneal astigmatism; CESC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg12463550 chr7:65579703 CRCP 0.55 6.86 0.39 4.77e-11 Aortic root size; CESC cis rs10791097 0.967 rs10750450 chr11:130719061 G/T cg12179176 chr11:130786555 SNX19 0.58 8.41 0.46 2.64e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7828089 0.542 rs7332050 chr8:22265294 G/T cg13512537 chr8:22265999 SLC39A14 -0.37 -5.1 -0.3 6.41e-7 Verbal declarative memory; CESC cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg09555818 chr19:45449301 APOC2 0.41 6.55 0.37 3.05e-10 Blood protein levels; CESC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1401999 1.000 rs3805108 chr3:183691650 T/C cg01324343 chr3:183735012 ABCC5 0.62 13.06 0.63 2.04e-30 Anterior chamber depth; CESC cis rs17376456 0.825 rs1470150 chr5:93138654 C/T cg25358565 chr5:93447407 FAM172A -0.88 -8.8 -0.48 1.77e-16 Diabetic retinopathy; CESC cis rs763121 0.853 rs8138996 chr22:39047435 G/T cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs9487051 1.000 rs9386796 chr6:109618704 C/T cg01475377 chr6:109611718 NA -0.41 -6.26 -0.36 1.57e-9 Reticulocyte fraction of red cells; CESC cis rs3812565 0.506 rs8413 chr9:139323311 T/C cg14019695 chr9:139328340 INPP5E 0.37 5.47 0.32 1.04e-7 Granulocyte percentage of myeloid white cells; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg09747232 chr8:103827049 NA -0.48 -7.19 -0.4 6.6e-12 Vertical cup-disc ratio; CESC cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 5.6 0.33 5.32e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7520050 0.933 rs6666743 chr1:46311275 C/T cg03146154 chr1:46216737 IPP -0.48 -6.36 -0.36 8.91e-10 Red blood cell count;Reticulocyte count; CESC cis rs7107174 1.000 rs10793311 chr11:78104399 G/C cg02023728 chr11:77925099 USP35 0.47 6.17 0.35 2.54e-9 Testicular germ cell tumor; CESC cis rs7020830 0.898 rs6476617 chr9:37200103 G/A cg14294708 chr9:37120828 ZCCHC7 1.21 23.37 0.82 2.5e-66 Schizophrenia; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15688767 chr3:125093330 ZNF148 0.46 6.09 0.35 3.85e-9 Gut microbiota (bacterial taxa); CESC cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg05340658 chr4:99064831 C4orf37 0.8 12.42 0.61 3.31e-28 Colonoscopy-negative controls vs population controls; CESC cis rs9905704 0.918 rs444393 chr17:56709222 A/G cg12560992 chr17:57184187 TRIM37 0.59 7.05 0.4 1.52e-11 Testicular germ cell tumor; CESC cis rs3806843 0.518 rs2569188 chr5:140008419 G/A cg26395211 chr5:140044315 WDR55 0.43 5.41 0.32 1.43e-7 Depressive symptoms (multi-trait analysis); CESC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg08736216 chr1:53307985 ZYG11A -0.38 -6.48 -0.37 4.45e-10 Monocyte count; CESC trans rs718857 0.524 rs10820587 chr9:106721207 A/G cg12446722 chr1:226374380 ACBD3 -0.48 -6.01 -0.35 6.23e-9 Breast cancer; CESC cis rs117623576 0.715 rs11008755 chr10:32360053 C/T cg03047570 chr10:32398778 NA 0.55 5.84 0.34 1.55e-8 Anti-saccade response; CESC cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg16240275 chr20:61666158 NCRNA00029 0.5 8.95 0.48 6.42e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs2243480 1.000 rs316330 chr7:65605372 C/A cg18252515 chr7:66147081 NA -1.41 -14.48 -0.66 2.11e-35 Diabetic kidney disease; CESC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.35 0.31 1.94e-7 Major depressive disorder; CESC cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.43 0.46 2.22e-15 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg16145915 chr7:1198662 ZFAND2A -0.43 -6.01 -0.35 6.23e-9 Longevity;Endometriosis; CESC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.8 10.57 0.54 4.93e-22 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04791162 chr14:62331287 NA -0.53 -6.15 -0.35 2.91e-9 Gut microbiome composition (summer); CESC cis rs938554 0.577 rs4591605 chr4:10002719 T/C cg00071950 chr4:10020882 SLC2A9 0.59 7.2 0.4 6.16e-12 Blood metabolite levels; CESC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg10691866 chr7:65817282 TPST1 0.33 5.52 0.32 8.07e-8 Aortic root size; CESC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg02725872 chr8:58115012 NA -0.45 -7.04 -0.4 1.66e-11 Developmental language disorder (linguistic errors); CESC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg10664184 chr19:17420304 DDA1 0.44 5.16 0.3 4.74e-7 Systemic lupus erythematosus; CESC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.52 -6.82 -0.39 6.03e-11 Bipolar disorder; CESC cis rs9303542 0.559 rs1042818 chr17:46620111 T/C cg04904318 chr17:46607828 HOXB1 -0.57 -5.51 -0.32 8.4e-8 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs72772090 0.539 rs72773922 chr5:96116660 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -5.05 -0.3 8.36e-7 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs6964587 1.000 rs7789492 chr7:91668854 C/T cg17063962 chr7:91808500 NA 0.56 7.79 0.43 1.54e-13 Breast cancer; CESC cis rs698833 0.562 rs10182045 chr2:44704236 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.43 5.55 0.32 6.97e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs760805 0.965 rs4648883 chr1:25261203 T/C cg22509179 chr1:25234806 RUNX3 -0.6 -8.6 -0.47 6.95e-16 Allergic disease (asthma, hay fever or eczema); CESC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.09 0.6 4.37e-27 Alzheimer's disease; CESC cis rs7799006 0.593 rs12531150 chr7:2289888 C/T cg12745145 chr7:2261452 MAD1L1 -0.32 -5.16 -0.3 4.9e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs6831352 0.918 rs34876213 chr4:100062216 G/A cg13256891 chr4:100009986 ADH5 -0.76 -8.3 -0.45 5.34e-15 Alcohol dependence; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20300707 chr1:1162156 SDF4 -0.59 -6.99 -0.39 2.23e-11 Gut microbiome composition (summer); CESC trans rs11098499 0.863 rs3822194 chr4:120471648 A/G cg25214090 chr10:38739885 LOC399744 0.67 9.27 0.49 6.8e-18 Corneal astigmatism; CESC cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg08822215 chr16:89438651 ANKRD11 -0.36 -5.44 -0.32 1.21e-7 Multiple myeloma (IgH translocation); CESC cis rs17401966 0.894 rs12141201 chr1:10454714 G/A cg15208524 chr1:10270712 KIF1B 0.41 5.22 0.31 3.59e-7 Hepatocellular carcinoma; CESC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg23754390 chr11:835074 CD151 0.32 5.7 0.33 3.26e-8 Mean platelet volume; CESC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg07677032 chr17:61819896 STRADA 0.42 5.3 0.31 2.48e-7 Height; CESC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg18876405 chr7:65276391 NA -0.54 -7.06 -0.4 1.46e-11 Aortic root size; CESC cis rs4664308 0.967 rs17831329 chr2:160915819 T/C cg03641300 chr2:160917029 PLA2R1 -0.67 -10.11 -0.53 1.61e-20 Idiopathic membranous nephropathy; CESC cis rs4654899 0.758 rs2320826 chr1:21392096 A/C cg05370193 chr1:21551575 ECE1 0.35 5.33 0.31 2.05e-7 Superior frontal gyrus grey matter volume; CESC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg04414720 chr1:150670196 GOLPH3L 0.57 8.08 0.44 2.36e-14 Tonsillectomy; CESC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg18876405 chr7:65276391 NA -0.49 -6.83 -0.39 5.72e-11 Aortic root size; CESC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.72 -0.33 2.82e-8 Parkinson's disease; CESC trans rs7824557 0.527 rs2736296 chr8:11234844 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -6.06 -0.35 4.78e-9 Retinal vascular caliber; CESC cis rs17407555 0.821 rs80278615 chr4:10143666 G/A cg00071950 chr4:10020882 SLC2A9 -0.55 -5.19 -0.3 4.16e-7 Schizophrenia (age at onset); CESC cis rs1568889 1.000 rs34337978 chr11:28136746 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 9.44 0.5 2.08e-18 Bipolar disorder; CESC cis rs6964587 1.000 rs4644173 chr7:91759597 A/G cg17063962 chr7:91808500 NA 0.56 7.79 0.43 1.55e-13 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02366844 chr16:31044544 STX4 0.54 6.32 0.36 1.09e-9 Gut microbiome composition (summer); CESC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg06600287 chr1:53387719 ECHDC2 -0.3 -5.34 -0.31 1.98e-7 Monocyte count; CESC cis rs2997447 0.802 rs75786059 chr1:26449327 A/G cg24596570 chr1:26146463 FAM54B;LOC646471 0.58 5.07 0.3 7.52e-7 QRS complex (12-leadsum); CESC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg26314531 chr2:26401878 FAM59B 0.86 9.22 0.49 9.81e-18 Gut microbiome composition (summer); CESC cis rs4950322 0.570 rs72691093 chr1:146769662 C/T cg22381352 chr1:146742008 CHD1L -0.46 -5.05 -0.3 8.32e-7 Protein quantitative trait loci; CESC cis rs7259376 0.777 rs7247735 chr19:22575488 C/T cg02657401 chr19:22469223 NA 0.26 5.14 0.3 5.27e-7 Menopause (age at onset); CESC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg17650747 chr5:1873721 NA 0.43 5.96 0.34 8.13e-9 Cardiovascular disease risk factors; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg01852063 chr16:1500567 CLCN7 0.41 6.08 0.35 4.28e-9 Fibrinogen levels; CESC cis rs77106637 0.929 rs77464186 chr11:72460398 A/C cg04827223 chr11:72435913 ARAP1 -0.57 -5.49 -0.32 9.48e-8 Type 2 diabetes; CESC cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.44 5.54 0.32 7.38e-8 Colorectal cancer; CESC trans rs11250098 0.541 rs6997839 chr8:10766028 T/C cg15556689 chr8:8085844 FLJ10661 -0.55 -6.36 -0.36 8.91e-10 Morning vs. evening chronotype; CESC cis rs2180341 1.000 rs2326567 chr6:127606160 G/A cg27446573 chr6:127587934 RNF146 1.08 16.13 0.7 3.14e-41 Breast cancer; CESC cis rs9399137 0.507 rs12664898 chr6:135288663 T/C cg22676075 chr6:135203613 NA 0.54 7.07 0.4 1.38e-11 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs17362650 0.960 rs13011033 chr2:9657312 G/C cg12832956 chr2:9616023 IAH1 -0.52 -5.09 -0.3 6.69e-7 Alcohol dependence (age at onset); CESC cis rs2617583 0.868 rs2617596 chr5:1446719 C/G cg07151155 chr5:1473589 LPCAT1 -0.35 -5.32 -0.31 2.24e-7 Breast cancer; CESC cis rs2635047 0.638 rs1434529 chr18:44730142 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.47 0.32 1.03e-7 Educational attainment; CESC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg07700843 chr1:2391317 NA -0.42 -7.01 -0.4 1.97e-11 Non-obstructive azoospermia; CESC cis rs7542091 0.635 rs985431 chr1:210043948 A/T cg25204440 chr1:209979598 IRF6 0.37 5.1 0.3 6.55e-7 Monobrow; CESC cis rs34779708 0.766 rs7913451 chr10:35551525 T/C cg04310649 chr10:35416472 CREM -0.48 -5.38 -0.31 1.62e-7 Inflammatory bowel disease;Crohn's disease; CESC cis rs9309711 0.961 rs11890651 chr2:3482796 T/G cg10845886 chr2:3471009 TTC15 -0.88 -12.59 -0.61 8.31e-29 Neurofibrillary tangles; CESC cis rs9287719 0.967 rs4668691 chr2:10740494 C/T cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs9916302 0.706 rs4332770 chr17:37704712 T/C cg20243544 chr17:37824526 PNMT 0.53 5.26 0.31 3.03e-7 Glomerular filtration rate (creatinine); CESC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg15813090 chr5:442598 EXOC3;C5orf55 0.41 6.17 0.35 2.55e-9 Cystic fibrosis severity; CESC cis rs55986470 0.670 rs10204157 chr2:239422669 C/G cg18131467 chr2:239335373 ASB1 -0.53 -5.93 -0.34 9.51e-9 Chronotype; CESC cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg23711669 chr6:146136114 FBXO30 0.79 9.78 0.52 1.7e-19 Lobe attachment (rater-scored or self-reported); CESC cis rs72781680 0.752 rs72796114 chr2:23906133 C/G cg08917208 chr2:24149416 ATAD2B 1.16 10.42 0.54 1.59e-21 Lymphocyte counts; CESC cis rs863345 0.625 rs12075903 chr1:158458932 A/G cg12129480 chr1:158549410 OR10X1 -0.36 -7.15 -0.4 8.67e-12 Pneumococcal bacteremia; CESC cis rs3806843 0.705 rs35614340 chr5:140043618 C/G cg26395211 chr5:140044315 WDR55 0.48 6.15 0.35 2.79e-9 Depressive symptoms (multi-trait analysis); CESC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg03806693 chr22:41940476 POLR3H -1.25 -16.88 -0.72 6.4e-44 Vitiligo; CESC cis rs977987 0.806 rs4888420 chr16:75462998 G/C cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.05 0.35 4.95e-9 Colorectal cancer; CESC cis rs2180341 1.000 rs3798853 chr6:127636823 C/T cg27446573 chr6:127587934 RNF146 -1.07 -15.06 -0.68 1.94e-37 Breast cancer; CESC cis rs6812193 0.518 rs17236661 chr4:77196476 A/C cg20311846 chr4:77356250 SHROOM3 0.3 5.2 0.3 3.91e-7 Parkinson's disease; CESC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg19774624 chr17:42201019 HDAC5 -0.83 -12.64 -0.61 5.84e-29 Total body bone mineral density; CESC cis rs7684253 0.565 rs6830774 chr4:57816306 T/C cg21154227 chr4:57904332 IGFBP7 0.37 5.32 0.31 2.17e-7 Migraine; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22610194 chr7:77045539 PION -0.47 -6.13 -0.35 3.17e-9 Fibrinogen levels; CESC cis rs2777491 1.000 rs7167729 chr15:41721042 G/A cg02330683 chr15:41787940 ITPKA 0.48 7.08 0.4 1.26e-11 Ulcerative colitis; CESC cis rs9303401 0.538 rs3785493 chr17:56472119 G/T cg25039879 chr17:56429692 SUPT4H1 -0.64 -6.2 -0.36 2.17e-9 Cognitive test performance; CESC cis rs11711311 1.000 rs2603793 chr3:113496418 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.68 9.33 0.5 4.28e-18 IgG glycosylation; CESC cis rs8017423 0.904 rs11622257 chr14:90715014 C/T cg14092571 chr14:90743983 NA 0.55 8.23 0.45 8.44e-15 Mortality in heart failure; CESC cis rs742320 0.756 rs3765263 chr16:840378 A/G cg07501729 chr16:846077 CHTF18 0.37 5.44 0.32 1.2e-7 Mean corpuscular volume; CESC cis rs7635838 0.892 rs66974661 chr3:11482729 A/G cg00170343 chr3:11313890 ATG7 0.42 5.69 0.33 3.44e-8 HDL cholesterol; CESC cis rs5758659 0.652 rs133321 chr22:42405322 A/G cg04733989 chr22:42467013 NAGA 0.44 5.85 0.34 1.41e-8 Cognitive function; CESC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg12463550 chr7:65579703 CRCP 0.49 6.21 0.36 2.07e-9 Aortic root size; CESC cis rs7937682 0.889 rs516263 chr11:111484719 A/C cg09085632 chr11:111637200 PPP2R1B -0.95 -14.63 -0.67 6.08e-36 Primary sclerosing cholangitis; CESC cis rs910316 0.503 rs4903273 chr14:75441795 G/A cg15467112 chr14:75489610 MLH3 -0.34 -5.16 -0.3 4.85e-7 Height; CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg21496518 chr3:15374154 SH3BP5 0.43 6.71 0.38 1.16e-10 Breast cancer;Type 2 diabetes; CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg11965913 chr1:205819406 PM20D1 0.89 16.15 0.7 2.65e-41 Menarche (age at onset); CESC cis rs61996546 0.622 rs12907116 chr15:26857399 A/G cg14859324 chr15:26874363 GABRB3 -0.37 -5.03 -0.3 8.93e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs4471028 0.905 rs12544032 chr8:75291115 A/G cg17811994 chr8:74332829 STAU2 -0.3 -5.15 -0.3 5e-7 Waist circumference; CESC cis rs7927771 0.524 rs10769299 chr11:47865160 G/T cg20307385 chr11:47447363 PSMC3 0.63 8.82 0.48 1.53e-16 Subjective well-being; CESC cis rs10899021 0.512 rs10219168 chr11:74374453 A/T cg25880958 chr11:74394337 NA 0.47 6.03 0.35 5.51e-9 Response to metformin (IC50); CESC cis rs62344088 0.590 rs60845955 chr5:185094 C/T cg22857025 chr5:266934 NA -1.06 -7.52 -0.42 8.62e-13 Asthma (childhood onset); CESC trans rs11039798 0.920 rs11040013 chr11:48782862 G/A cg15704280 chr7:45808275 SEPT13 0.7 6.33 0.36 1.04e-9 Axial length; CESC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg02896835 chr1:92012615 NA -0.52 -6.76 -0.38 8.69e-11 Breast cancer; CESC cis rs7937682 0.602 rs503905 chr11:111390762 G/C cg22437258 chr11:111473054 SIK2 0.49 6.1 0.35 3.72e-9 Primary sclerosing cholangitis; CESC cis rs11785693 0.862 rs62491200 chr8:4998001 A/C cg26367366 chr8:4980734 NA 0.83 7.91 0.44 6.86e-14 Neuroticism (multi-trait analysis);Neuroticism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06514377 chr2:3320918 TSSC1 -0.58 -6.15 -0.35 2.88e-9 Gut microbiome composition (summer); CESC cis rs13102973 0.931 rs12643821 chr4:135859614 A/G cg14419869 chr4:135874104 NA -0.39 -6.11 -0.35 3.49e-9 Subjective well-being; CESC cis rs17125944 0.505 rs75838476 chr14:53242362 G/A cg13660082 chr14:53194042 PSMC6 -0.68 -5.9 -0.34 1.13e-8 Alzheimer's disease (late onset); CESC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg17747265 chr1:1875780 NA -0.57 -9.24 -0.49 8.4e-18 Body mass index; CESC cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg05283184 chr6:79620031 NA -0.41 -6.41 -0.37 6.52e-10 Intelligence (multi-trait analysis); CESC cis rs2197308 0.565 rs12809769 chr12:37909968 C/T cg13010199 chr12:38710504 ALG10B 0.53 6.76 0.38 8.79e-11 Morning vs. evening chronotype; CESC cis rs433852 0.904 rs8102492 chr19:49140809 A/C cg06530960 chr19:49140787 SEC1;DBP 0.55 6.86 0.39 4.72e-11 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; CESC cis rs4835473 0.897 rs11100812 chr4:144711553 T/C cg25736465 chr4:144833511 NA 0.33 5.41 0.32 1.41e-7 Immature fraction of reticulocytes; CESC cis rs1355223 0.872 rs913204 chr11:34706224 C/G cg11058730 chr11:34937778 PDHX;APIP 0.51 6.66 0.38 1.62e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs7589342 0.894 rs7557976 chr2:106435061 C/A cg16077055 chr2:106428750 NCK2 0.53 7.56 0.42 6.6e-13 Addiction; CESC cis rs1670533 0.585 rs6827206 chr4:1065071 A/T cg04106633 chr4:1044584 NA 0.41 5.24 0.31 3.23e-7 Recombination rate (females); CESC cis rs7520050 0.966 rs11810993 chr1:46478793 A/G cg03146154 chr1:46216737 IPP -0.46 -5.88 -0.34 1.26e-8 Red blood cell count;Reticulocyte count; CESC cis rs4867766 0.585 rs10043212 chr5:173949740 C/T cg20434911 chr5:173954559 NA 0.57 5.59 0.32 5.54e-8 Stroke; CESC cis rs478304 0.651 rs11227299 chr11:65549570 C/G cg27068330 chr11:65405492 SIPA1 -0.47 -5.67 -0.33 3.69e-8 Acne (severe); CESC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg00484396 chr16:3507460 NAT15 -0.42 -5.91 -0.34 1.06e-8 Tuberculosis; CESC trans rs2472476 0.900 rs4742922 chr9:107520596 G/A cg14553338 chr2:66689807 MEIS1 0.45 6.33 0.36 1.02e-9 Obesity-related traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00473112 chr11:507177 RNH1 0.68 7.63 0.42 4.14e-13 Gut microbiome composition (summer); CESC cis rs8060686 0.641 rs73612222 chr16:68216072 A/G cg26727032 chr16:67993705 SLC12A4 -0.52 -6.01 -0.35 6.19e-9 HDL cholesterol;Metabolic syndrome; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22561380 chr8:42829775 HOOK3 0.46 6.49 0.37 4.27e-10 Fibrinogen levels; CESC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.54 5.07 0.3 7.35e-7 Lung cancer in ever smokers; CESC cis rs11650494 0.710 rs8065814 chr17:47470720 T/C cg08112188 chr17:47440006 ZNF652 0.84 6.39 0.37 7.58e-10 Prostate cancer; CESC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg09263875 chr16:632152 PIGQ 0.65 10.85 0.55 6.36e-23 Height; CESC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.24 -0.41 4.79e-12 Developmental language disorder (linguistic errors); CESC cis rs11270836 1 rs11270836 chr4:38625915 T/TACATTATGTCATTTCACA cg18361445 chr4:38666374 KLF3;FLJ13197 0.54 7.67 0.43 3.39e-13 Mumps; CESC cis rs9287719 0.967 rs2287062 chr2:10743191 G/A cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs17666538 0.792 rs7820788 chr8:601846 C/T cg02524346 chr8:600233 NA 0.81 6.4 0.37 7.21e-10 IgG glycosylation; CESC cis rs4820539 1.000 rs885963 chr22:23460939 G/T cg14186256 chr22:23484241 RTDR1 0.82 14.91 0.68 6.55e-37 Bone mineral density; CESC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.89 13.44 0.64 9.54e-32 Prudent dietary pattern; CESC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.9 13.67 0.64 1.44e-32 Prudent dietary pattern; CESC cis rs7635838 0.619 rs346087 chr3:11274354 A/G cg00170343 chr3:11313890 ATG7 0.51 7.12 0.4 1.04e-11 HDL cholesterol; CESC cis rs2635047 0.901 rs2684837 chr18:44749884 A/C cg24371990 chr18:44770781 NA 0.33 5.2 0.3 4.05e-7 Educational attainment; CESC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg21144161 chr5:423903 AHRR 0.37 5.99 0.35 6.64e-9 Cystic fibrosis severity; CESC cis rs9911578 1.000 rs2567905 chr17:56782297 T/C cg12560992 chr17:57184187 TRIM37 0.92 15.46 0.69 7.24e-39 Intelligence (multi-trait analysis); CESC cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg16339924 chr4:17578868 LAP3 0.65 8.27 0.45 6.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg11987759 chr7:65425863 GUSB -0.43 -5.75 -0.33 2.46e-8 Calcium levels; CESC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg19163074 chr7:65112434 INTS4L2 -0.41 -5.11 -0.3 6.29e-7 Aortic root size; CESC cis rs870825 0.616 rs28375770 chr4:185647395 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.59e-11 Blood protein levels; CESC cis rs7017914 0.934 rs7009297 chr8:71672366 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.41 -5.2 -0.3 3.94e-7 Bone mineral density; CESC cis rs3733585 0.773 rs13107466 chr4:10019390 G/A cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.73e-37 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7107174 1.000 rs2512535 chr11:77971468 C/T cg02023728 chr11:77925099 USP35 0.42 6.0 0.35 6.49e-9 Testicular germ cell tumor; CESC cis rs3105593 0.547 rs3131559 chr15:50780214 C/A cg05456662 chr15:50716270 USP8 0.45 6.05 0.35 5.04e-9 QT interval; CESC cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg19418458 chr7:158789849 NA -0.48 -7.77 -0.43 1.72e-13 Facial morphology (factor 20); CESC cis rs13385 0.769 rs6871511 chr5:139592314 G/A cg26211634 chr5:139558579 C5orf32 0.46 5.06 0.3 7.92e-7 Atrial fibrillation; CESC cis rs9913156 0.793 rs11568061 chr17:4546445 G/A cg00122941 chr17:4613640 ARRB2 0.84 9.37 0.5 3.42e-18 Lymphocyte counts; CESC cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg23711669 chr6:146136114 FBXO30 0.99 15.04 0.68 2.25e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg18230493 chr5:56204884 C5orf35 -0.74 -9.05 -0.49 3.27e-17 Initial pursuit acceleration; CESC cis rs7274811 0.681 rs291707 chr20:31964256 G/A cg21523528 chr20:32077966 CBFA2T2 -0.43 -5.13 -0.3 5.7e-7 Height; CESC cis rs35110281 0.715 rs8129601 chr21:45119104 A/G cg01579765 chr21:45077557 HSF2BP -0.52 -8.83 -0.48 1.43e-16 Mean corpuscular volume; CESC cis rs854765 0.583 rs4414547 chr17:17859052 G/T cg16928487 chr17:17741425 SREBF1 -0.57 -9.57 -0.51 7.66e-19 Total body bone mineral density; CESC cis rs2230307 0.536 rs11166385 chr1:100443462 A/G cg24955406 chr1:100503596 HIAT1 0.55 5.48 0.32 9.85e-8 Carotid intima media thickness; CESC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg23281280 chr6:28129359 ZNF389 0.48 6.32 0.36 1.1e-9 Parkinson's disease; CESC cis rs6570726 0.935 rs414646 chr6:145831685 T/C cg05347473 chr6:146136440 FBXO30 0.49 6.69 0.38 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg09784847 chr2:74692550 MOGS -0.49 -6.0 -0.35 6.58e-9 Ulcerative colitis; CESC trans rs61931739 0.500 rs11053273 chr12:34547255 C/T cg13010199 chr12:38710504 ALG10B 0.51 6.58 0.37 2.47e-10 Morning vs. evening chronotype; CESC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg23985595 chr17:80112537 CCDC57 -0.43 -6.63 -0.38 1.88e-10 Life satisfaction; CESC cis rs1707322 0.752 rs10430105 chr1:46138876 G/A cg05343316 chr1:45956843 TESK2 0.51 6.32 0.36 1.09e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7089973 0.872 rs7923295 chr10:116625159 C/G cg23260525 chr10:116636907 FAM160B1 -0.37 -6.31 -0.36 1.19e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9640161 0.830 rs3757423 chr7:150067714 A/G cg10018233 chr7:150070692 REPIN1 -0.47 -8.71 -0.47 3.32e-16 Blood protein levels;Circulating chemerin levels; CESC cis rs9318086 0.712 rs9318099 chr13:24442462 C/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.42 -5.91 -0.34 1.03e-8 Myopia (pathological); CESC cis rs2180341 0.960 rs7751865 chr6:127683040 G/A cg24812749 chr6:127587940 RNF146 1.05 15.15 0.68 9.37e-38 Breast cancer; CESC cis rs4975709 0.569 rs931509 chr5:1858821 A/T cg11168104 chr5:1857477 NA -0.39 -5.57 -0.32 6.25e-8 Cardiovascular disease risk factors; CESC cis rs1448094 0.773 rs11117100 chr12:86310392 A/G cg02569458 chr12:86230093 RASSF9 0.37 5.25 0.31 3.19e-7 Major depressive disorder; CESC cis rs453301 0.653 rs7005133 chr8:8901222 T/G cg15556689 chr8:8085844 FLJ10661 0.51 6.38 0.36 8e-10 Joint mobility (Beighton score); CESC cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.5 6.59 0.38 2.42e-10 Personality dimensions; CESC cis rs962856 0.619 rs1601529 chr2:67594837 A/T cg09028215 chr2:67624308 ETAA1 0.44 5.32 0.31 2.19e-7 Pancreatic cancer; CESC cis rs412050 0.547 rs78907487 chr22:22151939 A/C cg17089214 chr22:22089827 YPEL1 0.68 5.82 0.34 1.7e-8 Attention deficit hyperactivity disorder; CESC trans rs877282 1.000 rs877282 chr10:771532 G/A cg22713356 chr15:30763199 NA 1.26 12.77 0.62 2.03e-29 Uric acid levels; CESC cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -5.98 -0.34 7.15e-9 Alzheimer's disease; CESC cis rs1355223 0.583 rs1396880 chr11:34870552 C/T cg11058730 chr11:34937778 PDHX;APIP -0.79 -11.95 -0.59 1.33e-26 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg25019033 chr10:957182 NA -0.58 -6.21 -0.36 2.03e-9 Eosinophil percentage of granulocytes; CESC cis rs7918232 0.800 rs7907981 chr10:27444329 T/C cg14240646 chr10:27532245 ACBD5 -0.67 -7.25 -0.41 4.55e-12 Breast cancer; CESC cis rs4523957 0.890 rs8076939 chr17:2099931 C/A cg16513277 chr17:2031491 SMG6 -0.66 -8.99 -0.48 4.8e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs3105593 1.000 rs3131577 chr15:50863516 G/A cg08437265 chr15:50716283 USP8 0.43 5.56 0.32 6.74e-8 QT interval; CESC cis rs11190604 1.000 rs11190552 chr10:102206607 G/A cg07080220 chr10:102295463 HIF1AN 0.55 5.51 0.32 8.5e-8 Palmitoleic acid (16:1n-7) levels; CESC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg17376030 chr22:41985996 PMM1 0.67 7.26 0.41 4.21e-12 Vitiligo; CESC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg02475777 chr4:1388615 CRIPAK -0.47 -6.15 -0.35 2.9e-9 Obesity-related traits; CESC cis rs10131894 0.635 rs174997 chr14:75434806 G/A cg08847533 chr14:75593920 NEK9 -0.77 -12.2 -0.6 1.77e-27 Coronary artery disease; CESC cis rs1008375 1.000 rs55939327 chr4:17642937 T/A cg02297831 chr4:17616191 MED28 0.53 6.71 0.38 1.2e-10 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs897080 0.515 rs1067343 chr2:44621042 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.51 0.32 8.58e-8 Height; CESC trans rs11098499 0.775 rs67281037 chr4:120281157 G/C cg25214090 chr10:38739885 LOC399744 0.65 9.11 0.49 2.04e-17 Corneal astigmatism; CESC cis rs9611519 0.929 rs12484971 chr22:41439304 A/T cg03806693 chr22:41940476 POLR3H -0.56 -5.88 -0.34 1.22e-8 Neuroticism; CESC cis rs4835473 0.604 rs11938387 chr4:144905629 T/C cg25736465 chr4:144833511 NA 0.41 6.25 0.36 1.65e-9 Immature fraction of reticulocytes; CESC cis rs6426558 0.537 rs2813950 chr1:227426072 A/G cg10327440 chr1:227177885 CDC42BPA -0.47 -6.17 -0.35 2.54e-9 Neutrophil percentage of white cells; CESC cis rs2197308 0.765 rs68029712 chr12:37906585 T/G cg26384229 chr12:38710491 ALG10B 0.75 11.12 0.56 7.84e-24 Morning vs. evening chronotype; CESC cis rs8060686 0.858 rs13334918 chr16:67901343 A/G cg26727032 chr16:67993705 SLC12A4 -0.65 -9.58 -0.51 7.54e-19 HDL cholesterol;Metabolic syndrome; CESC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg26314531 chr2:26401878 FAM59B 0.53 6.0 0.35 6.49e-9 Gut microbiome composition (summer); CESC cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg24308560 chr3:49941425 MST1R 0.58 8.15 0.45 1.47e-14 Body mass index; CESC cis rs9346455 1.000 rs12055385 chr6:71996789 G/A cg27238071 chr6:71998145 OGFRL1 0.59 5.14 0.3 5.47e-7 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs1124376 0.882 rs6791385 chr3:20136439 A/C cg05072819 chr3:20081367 KAT2B 0.47 5.38 0.31 1.61e-7 Bipolar disorder and schizophrenia; CESC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg10560079 chr2:191398806 TMEM194B 0.49 6.85 0.39 5.15e-11 Pulse pressure; CESC cis rs7208859 0.623 rs9890862 chr17:29125450 C/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12142240 0.698 rs1053628 chr1:46827769 C/T cg10495392 chr1:46806563 NSUN4 0.58 6.32 0.36 1.12e-9 Menopause (age at onset); CESC cis rs17761864 0.579 rs12325821 chr17:2050166 G/T cg16513277 chr17:2031491 SMG6 0.41 5.27 0.31 2.82e-7 Esophageal cancer (squamous cell); CESC cis rs2273669 0.667 rs12204576 chr6:109318843 A/G cg05315195 chr6:109294784 ARMC2 -0.66 -6.37 -0.36 8.17e-10 Prostate cancer; CESC cis rs5758659 0.652 rs133347 chr22:42423645 A/T cg04733989 chr22:42467013 NAGA 0.48 6.67 0.38 1.52e-10 Cognitive function; CESC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.52 0.32 7.94e-8 Bipolar disorder; CESC cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -6.88 -0.39 4.26e-11 Hemoglobin concentration; CESC cis rs4808199 0.894 rs10418051 chr19:19397789 C/T cg03709012 chr19:19516395 GATAD2A 1.03 11.89 0.59 2.05e-26 Nonalcoholic fatty liver disease; CESC cis rs56046484 0.956 rs34889576 chr15:85664676 A/G cg08123816 chr15:85640762 PDE8A -0.5 -6.19 -0.36 2.23e-9 Testicular germ cell tumor; CESC cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.32 0.5 4.9e-18 Age-related macular degeneration (geographic atrophy); CESC cis rs7647973 1.000 rs9862534 chr3:49598064 A/G cg07636037 chr3:49044803 WDR6 0.69 9.69 0.51 3.42e-19 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05049096 chr10:5855588 GDI2 0.58 6.11 0.35 3.47e-9 Gut microbiome composition (summer); CESC cis rs6893300 0.922 rs62406187 chr5:179185686 C/T cg14593053 chr5:179126677 CANX -0.53 -5.76 -0.33 2.29e-8 Resting heart rate; CESC cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC cis rs4664304 1.000 rs4664304 chr2:160794008 A/G cg03641300 chr2:160917029 PLA2R1 -0.48 -6.62 -0.38 1.99e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs2933343 0.953 rs2933344 chr3:128658715 A/G cg25356066 chr3:128598488 ACAD9 0.58 7.24 0.41 4.97e-12 IgG glycosylation; CESC cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg02487422 chr3:49467188 NICN1 0.43 5.54 0.32 7.11e-8 Parkinson's disease; CESC cis rs4664304 0.629 rs56122507 chr2:160847353 T/C cg03641300 chr2:160917029 PLA2R1 -0.43 -5.82 -0.34 1.69e-8 Crohn's disease;Inflammatory bowel disease; CESC trans rs2391518 0.587 rs2969002 chr4:130782328 G/T cg04981619 chr2:43328122 NA 0.38 6.0 0.35 6.59e-9 Body mass index; CESC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.39 5.2 0.3 4.06e-7 Menopause (age at onset); CESC cis rs6060717 0.529 rs6060535 chr20:34235522 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.61 5.15 0.3 5.03e-7 Hip circumference adjusted for BMI; CESC cis rs7827545 0.644 rs7386524 chr8:135534005 T/C cg17885191 chr8:135476712 NA -0.52 -6.95 -0.39 2.92e-11 Hypertension (SNP x SNP interaction); CESC cis rs12325245 0.536 rs71375919 chr16:58547522 C/T cg01152986 chr16:58549298 SETD6 0.85 5.09 0.3 6.71e-7 Schizophrenia; CESC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg23161317 chr6:28129485 ZNF389 0.49 6.12 0.35 3.33e-9 Parkinson's disease; CESC cis rs6598955 0.671 rs11247880 chr1:26568926 G/A cg19743891 chr1:26644573 UBXN11;CD52 0.38 5.19 0.3 4.09e-7 Obesity-related traits; CESC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg06873352 chr17:61820015 STRADA 0.49 7.14 0.4 8.86e-12 Height; CESC cis rs11583043 0.708 rs1335745 chr1:101546439 T/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 5.48 0.32 9.66e-8 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs6991838 0.584 rs4275254 chr8:66501364 A/G cg13398993 chr8:66546079 ARMC1 -0.46 -5.58 -0.32 5.82e-8 Intelligence (multi-trait analysis); CESC cis rs7520050 0.966 rs4660910 chr1:46548402 G/T cg03146154 chr1:46216737 IPP -0.44 -5.69 -0.33 3.34e-8 Red blood cell count;Reticulocyte count; CESC cis rs8028182 0.636 rs7175852 chr15:75694535 C/T cg20655648 chr15:75932815 IMP3 0.45 5.52 0.32 8.15e-8 Sudden cardiac arrest; CESC cis rs7107174 0.901 rs10899473 chr11:78042983 A/C cg02023728 chr11:77925099 USP35 0.41 5.79 0.34 2e-8 Testicular germ cell tumor; CESC cis rs7662987 1.000 rs7658127 chr4:99994622 C/G cg13256891 chr4:100009986 ADH5 -0.83 -6.1 -0.35 3.82e-9 Smoking initiation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26449450 chr19:12228348 NA -0.61 -7.18 -0.4 7.03e-12 Gut microbiome composition (summer); CESC cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg20307385 chr11:47447363 PSMC3 -0.61 -7.38 -0.41 2.05e-12 Subjective well-being; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg05793409 chr1:35658810 SFPQ -0.52 -6.8 -0.39 6.88e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs8062405 0.573 rs8045689 chr16:28988269 C/T cg05966235 chr16:28915196 ATP2A1 -0.41 -5.81 -0.34 1.82e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs2276314 1.000 rs4799835 chr18:33571268 G/A cg05985134 chr18:33552581 C18orf21 0.64 7.2 0.4 6.39e-12 Endometriosis;Drug-induced torsades de pointes; CESC cis rs1163251 0.902 rs511059 chr1:120217081 G/T cg19096424 chr1:120255104 PHGDH 0.43 5.22 0.31 3.62e-7 Blood metabolite levels; CESC cis rs668210 0.793 rs506873 chr11:65767215 A/C cg02427764 chr11:65769310 BANF1;EIF1AD -0.5 -5.08 -0.3 7.29e-7 Cerebrospinal fluid biomarker levels; CESC cis rs3741151 1.000 rs57893472 chr11:73042826 C/T cg17517138 chr11:73019481 ARHGEF17 0.62 5.15 0.3 5.08e-7 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg12463550 chr7:65579703 CRCP -0.46 -5.86 -0.34 1.34e-8 Aortic root size; CESC cis rs74181299 0.750 rs12472718 chr2:65327620 G/A cg05010058 chr2:65284262 CEP68 -0.31 -5.24 -0.31 3.32e-7 Pulse pressure; CESC cis rs12995491 0.933 rs34029976 chr2:88537797 T/C cg18490616 chr2:88469792 THNSL2 -0.54 -8.06 -0.44 2.59e-14 Response to metformin (IC50); CESC trans rs7618501 0.633 rs2252833 chr3:50004209 C/T cg21659725 chr3:3221576 CRBN 0.48 6.58 0.37 2.5e-10 Intelligence (multi-trait analysis); CESC cis rs6546537 0.550 rs72837959 chr2:69780762 C/T cg10773587 chr2:69614142 GFPT1 -0.43 -5.45 -0.32 1.16e-7 Serum thyroid-stimulating hormone levels; CESC cis rs9296736 0.922 rs614956 chr6:53950865 G/A cg04374786 chr6:53939321 C6orf142 0.36 5.64 0.33 4.28e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs7116495 0.609 rs949326 chr11:71730306 A/G cg10381502 chr11:71823885 C11orf51 1.04 7.3 0.41 3.38e-12 Severe influenza A (H1N1) infection; CESC cis rs9896933 0.832 rs77512810 chr17:80804589 C/T cg15664640 chr17:80829946 TBCD -0.54 -5.78 -0.33 2.05e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CESC cis rs1953600 0.837 rs3098105 chr10:81953266 C/T cg00277334 chr10:82204260 NA 0.45 6.28 0.36 1.4e-9 Sarcoidosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00205436 chr2:132766767 NA -0.51 -7.16 -0.4 7.76e-12 Gut microbiome composition (summer); CESC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg06600287 chr1:53387719 ECHDC2 -0.27 -5.05 -0.3 8.13e-7 Monocyte count; CESC cis rs2404602 0.692 rs12437733 chr15:77155562 A/G cg22467129 chr15:76604101 ETFA -0.35 -5.27 -0.31 2.8e-7 Blood metabolite levels; CESC cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg20503657 chr10:835505 NA 0.7 7.89 0.44 7.91e-14 Eosinophil percentage of granulocytes; CESC cis rs12497850 0.829 rs8926 chr3:49052785 T/A cg02487422 chr3:49467188 NICN1 0.45 5.72 0.33 2.91e-8 Parkinson's disease; CESC cis rs9388451 0.626 rs3799708 chr6:126078530 C/T cg05901451 chr6:126070800 HEY2 -0.62 -9.44 -0.5 2e-18 Brugada syndrome; CESC cis rs3540 0.512 rs3862434 chr15:91080387 C/T cg10434728 chr15:90938212 IQGAP1 0.4 7.1 0.4 1.11e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs35146811 0.586 rs6964754 chr7:99589404 G/A cg22906224 chr7:99728672 NA 0.43 5.18 0.3 4.42e-7 Coronary artery disease; CESC cis rs950169 0.579 rs11633088 chr15:84672181 A/T cg17507749 chr15:85114479 UBE2QP1 -0.58 -5.8 -0.34 1.84e-8 Schizophrenia; CESC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg13628971 chr7:2884303 GNA12 0.61 8.35 0.46 3.73e-15 Height; CESC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.34 -5.63 -0.33 4.6e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.2 0.4 6.31e-12 Bipolar disorder; CESC cis rs9300255 0.602 rs1727294 chr12:123616514 A/G cg00376283 chr12:123451042 ABCB9 0.69 8.61 0.47 6.6e-16 Neutrophil percentage of white cells; CESC cis rs854765 0.583 rs11078405 chr17:17824978 G/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.48 6.23 0.36 1.86e-9 Total body bone mineral density; CESC cis rs2880765 0.835 rs7168860 chr15:86037030 G/A cg10818794 chr15:86012489 AKAP13 -0.34 -5.33 -0.31 2.11e-7 Coronary artery disease; CESC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.2 -0.3 4.05e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs473651 0.935 rs541128 chr2:239336449 A/G cg21699342 chr2:239360505 ASB1 0.56 9.61 0.51 6.14e-19 Multiple system atrophy; CESC cis rs9486715 0.825 rs211158 chr6:97022938 C/G cg06623918 chr6:96969491 KIAA0776 -0.8 -11.8 -0.59 4.22e-26 Headache; CESC cis rs820218 0.926 rs820155 chr17:73663778 G/C cg01592526 chr17:73663357 RECQL5;SAP30BP 0.44 5.65 0.33 4.15e-8 Rotator cuff tears; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16531660 chr3:141457093 RNF7 0.57 6.39 0.37 7.41e-10 Gut microbiome composition (summer); CESC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg09165964 chr15:75287851 SCAMP5 0.49 6.49 0.37 4.18e-10 Breast cancer; CESC cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg26597838 chr10:835615 NA 0.86 8.97 0.48 5.53e-17 Eosinophil percentage of granulocytes; CESC cis rs36051895 0.502 rs10975003 chr9:5213687 T/C cg02405213 chr9:5042618 JAK2 -0.45 -5.46 -0.32 1.07e-7 Pediatric autoimmune diseases; CESC cis rs34172651 0.917 rs11074651 chr16:24778409 A/G cg06028605 chr16:24865363 SLC5A11 0.34 5.37 0.31 1.73e-7 Intelligence (multi-trait analysis); CESC cis rs3741151 1.000 rs79794992 chr11:73049352 A/G cg17517138 chr11:73019481 ARHGEF17 1.07 7.37 0.41 2.12e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg10691866 chr7:65817282 TPST1 0.33 5.55 0.32 6.96e-8 Aortic root size; CESC cis rs9611565 0.918 rs9611562 chr22:41760172 T/G cg03806693 chr22:41940476 POLR3H -1.03 -11.75 -0.59 6.25e-26 Vitiligo; CESC cis rs2066819 1.000 rs57137641 chr12:56741228 G/A cg26734620 chr12:56694298 CS 0.98 5.95 0.34 8.45e-9 Psoriasis vulgaris; CESC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.0 9.63 0.51 5.12e-19 Platelet count; CESC cis rs2625529 0.556 rs1552134 chr15:72232898 T/A cg16672083 chr15:72433130 SENP8 0.43 6.2 0.36 2.1e-9 Red blood cell count; CESC cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg21573476 chr21:45109991 RRP1B -0.51 -7.27 -0.41 3.97e-12 Mean corpuscular volume; CESC cis rs7216064 1.000 rs7210027 chr17:65977053 C/T cg12091567 chr17:66097778 LOC651250 0.66 7.63 0.42 4.31e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs367615 0.660 rs10477972 chr5:108831951 C/A cg17395555 chr5:108820864 NA 0.64 11.03 0.56 1.56e-23 Colorectal cancer (SNP x SNP interaction); CESC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg05535760 chr7:792225 HEATR2 0.98 11.15 0.57 6.25e-24 Cerebrospinal P-tau181p levels; CESC cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg00033643 chr7:134001901 SLC35B4 0.42 5.39 0.31 1.55e-7 Mean platelet volume; CESC cis rs4472734 0.965 rs12074810 chr1:214619101 C/A cg00063699 chr1:214624242 PTPN14 -0.34 -5.26 -0.31 2.93e-7 Height; CESC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg16545954 chr1:2118288 C1orf86 -0.37 -7.02 -0.4 1.91e-11 Height; CESC cis rs3812049 0.826 rs17764730 chr5:127357526 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.89 10.96 0.56 2.78e-23 Lymphocyte counts;Red cell distribution width; CESC cis rs2535633 0.631 rs2245424 chr3:53003021 G/C cg07507251 chr3:52567010 NT5DC2 -0.31 -5.14 -0.3 5.4e-7 Body mass index; CESC cis rs208515 0.560 rs207084 chr6:66776966 T/C cg07460842 chr6:66804631 NA -1.04 -22.02 -0.8 8.43e-62 Exhaled nitric oxide levels; CESC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg04369109 chr6:150039330 LATS1 -0.39 -5.31 -0.31 2.3e-7 Lung cancer; CESC cis rs7809950 1.000 rs2237673 chr7:107131580 T/C cg23024343 chr7:107201750 COG5 -0.42 -5.99 -0.35 6.9e-9 Coronary artery disease; CESC cis rs11031096 0.782 rs11031110 chr11:4162652 G/C cg18678763 chr11:4115507 RRM1 -0.46 -6.31 -0.36 1.19e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg07636037 chr3:49044803 WDR6 -0.76 -11.82 -0.59 3.57e-26 Menarche (age at onset); CESC cis rs7084402 0.967 rs1649032 chr10:60279701 T/C cg07615347 chr10:60278583 BICC1 -0.59 -9.45 -0.5 1.83e-18 Refractive error; CESC cis rs9796 0.866 rs1678750 chr15:41410705 G/A cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.23 -0.36 1.78e-9 Menopause (age at onset); CESC trans rs945270 0.512 rs868200 chr14:56195998 T/G cg18102697 chr4:83542773 C4orf11 -0.43 -6.55 -0.37 3.06e-10 Subcortical brain region volumes; CESC cis rs7843479 0.601 rs11780532 chr8:21838670 T/A cg17168535 chr8:21777572 XPO7 0.72 11.42 0.57 8.1e-25 Mean corpuscular volume; CESC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg13206674 chr6:150067644 NUP43 0.39 5.58 0.32 5.93e-8 Lung cancer; CESC cis rs6831352 0.879 rs67311928 chr4:100048999 A/G cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC trans rs28549925 0.590 rs10228868 chr7:16968585 A/G cg01443946 chr12:5936980 ANO2 0.77 6.1 0.35 3.67e-9 Congenital heart disease (maternal effect);Conotruncal heart defects (maternal effects); CESC cis rs6662572 1.000 rs55951835 chr1:46132442 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.53 5.83 0.34 1.65e-8 Blood protein levels; CESC cis rs4662945 0.603 rs10496678 chr2:130262209 C/T cg05962382 chr2:130345044 NA -0.48 -6.82 -0.39 6.31e-11 Response to cytidine analogues (gemcitabine); CESC cis rs7017914 0.967 rs34042354 chr8:71730961 A/G cg23757474 chr8:71581111 LACTB2;XKR9 -0.44 -5.68 -0.33 3.58e-8 Bone mineral density; CESC cis rs7202877 0.706 rs4993971 chr16:75411634 C/G cg04384234 chr16:75411784 CFDP1 0.48 5.87 0.34 1.27e-8 Type 2 diabetes;Type 1 diabetes; CESC cis rs9926296 0.715 rs2115401 chr16:89740609 A/G cg12119029 chr16:89752879 CDK10 -0.32 -5.53 -0.32 7.62e-8 Vitiligo; CESC cis rs3008870 1.000 rs1925412 chr1:67405057 G/A cg02640540 chr1:67518911 SLC35D1 0.51 5.54 0.32 7.41e-8 Lymphocyte percentage of white cells; CESC cis rs66530629 0.874 rs7528154 chr1:25130083 T/C cg22509179 chr1:25234806 RUNX3 -0.43 -5.47 -0.32 1.05e-7 Plateletcrit; CESC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg10691866 chr7:65817282 TPST1 0.34 5.59 0.32 5.7e-8 Aortic root size; CESC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.65 0.38 1.71e-10 Prudent dietary pattern; CESC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg23982607 chr1:1823379 GNB1 -0.78 -12.63 -0.61 6.1e-29 Body mass index; CESC cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg25427524 chr10:38739819 LOC399744 -0.67 -9.69 -0.51 3.27e-19 Extrinsic epigenetic age acceleration; CESC cis rs2404602 0.692 rs34181263 chr15:77065388 C/T cg26408565 chr15:76604113 ETFA -0.38 -5.42 -0.32 1.32e-7 Blood metabolite levels; CESC cis rs4132509 0.744 rs59953491 chr1:243894953 C/T cg21452805 chr1:244014465 NA 0.53 6.34 0.36 9.77e-10 RR interval (heart rate); CESC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg25985355 chr7:65971099 NA 0.32 5.26 0.31 2.94e-7 Aortic root size; CESC cis rs17655565 0.533 rs12825729 chr12:52706854 G/A cg08257133 chr12:52711352 KRT83 0.5 8.66 0.47 4.68e-16 Plasma amyloid beta peptide concentrations (ABx-42); CESC trans rs561341 1.000 rs576985 chr17:30323323 C/T cg20587970 chr11:113659929 NA -1.44 -18.71 -0.75 2.25e-50 Hip circumference adjusted for BMI; CESC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 9.9 0.52 7.25e-20 Prudent dietary pattern; CESC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.82 0.39 6.31e-11 Electroencephalogram traits; CESC cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg23711669 chr6:146136114 FBXO30 0.93 12.15 0.6 2.61e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs1003719 0.715 rs762139 chr21:38568475 A/T cg08222185 chr21:46494823 ADARB1 -0.42 -6.12 -0.35 3.3e-9 Eye color traits; CESC cis rs6088590 0.735 rs2273684 chr20:33529766 G/T cg24642439 chr20:33292090 TP53INP2 -0.68 -9.06 -0.49 3.01e-17 Coronary artery disease; CESC cis rs5758659 0.652 rs6519301 chr22:42385967 A/G cg04733989 chr22:42467013 NAGA 0.42 5.56 0.32 6.71e-8 Cognitive function; CESC cis rs7937682 0.924 rs10891284 chr11:111527737 T/C cg22437258 chr11:111473054 SIK2 0.69 9.29 0.5 5.71e-18 Primary sclerosing cholangitis; CESC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg18016565 chr1:150552671 MCL1 -0.34 -5.16 -0.3 4.74e-7 Tonsillectomy; CESC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg13126279 chr21:47581558 C21orf56 -0.48 -6.41 -0.37 6.67e-10 Testicular germ cell tumor; CESC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg18337363 chr3:52569053 NT5DC2 0.29 5.16 0.3 4.73e-7 Bipolar disorder; CESC trans rs9858542 0.953 rs67216675 chr3:49493151 G/T cg21659725 chr3:3221576 CRBN -0.56 -6.57 -0.37 2.66e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs9311474 0.713 rs352165 chr3:52242902 A/G cg05315796 chr3:52349193 DNAH1 0.29 5.15 0.3 5.06e-7 Electroencephalogram traits; CESC cis rs1707322 0.721 rs61784800 chr1:46178112 A/G cg05343316 chr1:45956843 TESK2 -0.48 -6.09 -0.35 3.85e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.11 21.04 0.79 1.78e-58 Prudent dietary pattern; CESC cis rs7267979 1.000 rs6050566 chr20:25351071 G/A cg08601574 chr20:25228251 PYGB -0.38 -5.49 -0.32 9.43e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.81 0.34 1.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs12410462 0.681 rs74582965 chr1:227610126 C/T cg23173402 chr1:227635558 NA 0.74 6.46 0.37 4.96e-10 Major depressive disorder; CESC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.75 -0.33 2.39e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs1707322 1.000 rs4454479 chr1:46423555 G/A cg03146154 chr1:46216737 IPP 0.72 9.82 0.52 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg10792982 chr14:105748885 BRF1 0.4 5.1 0.3 6.45e-7 Mean platelet volume;Platelet distribution width; CESC cis rs7044106 0.708 rs959558 chr9:123368911 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.65 0.33 4.07e-8 Hip circumference adjusted for BMI; CESC cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg03676636 chr4:99064102 C4orf37 0.35 5.05 0.3 8.25e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9902453 1.000 rs4795525 chr17:28388487 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.87 -0.44 9.09e-14 Coffee consumption (cups per day); CESC cis rs28595532 0.668 rs58467651 chr4:119349011 T/G cg21605333 chr4:119757512 SEC24D 0.93 5.35 0.31 1.9e-7 Cannabis dependence symptom count; CESC cis rs3087591 0.960 rs1801052 chr17:29508775 C/T cg24425628 chr17:29625626 OMG;NF1 0.42 5.16 0.3 4.75e-7 Hip circumference; CESC cis rs9457247 0.565 rs12193698 chr6:167512073 C/A cg23791538 chr6:167370224 RNASET2 -0.54 -7.06 -0.4 1.48e-11 Crohn's disease; CESC cis rs4604732 0.527 rs77361748 chr1:247626475 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg19717773 chr7:2847554 GNA12 0.55 7.96 0.44 5.21e-14 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg19602773 chr3:52007747 ABHD14B;ABHD14A -0.47 -6.55 -0.37 2.94e-10 Fibrinogen levels; CESC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg13647721 chr17:30228624 UTP6 -0.61 -5.68 -0.33 3.47e-8 Hip circumference adjusted for BMI; CESC cis rs1691799 0.899 rs1168295 chr12:66734151 G/C cg16791601 chr12:66731901 HELB -0.75 -12.9 -0.62 7.25e-30 White blood cell count (basophil); CESC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg01988459 chr11:68622903 NA -0.41 -5.29 -0.31 2.53e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs228437 1.000 rs6934385 chr6:134916471 A/G cg24504307 chr6:134963096 NA 0.57 5.96 0.34 7.93e-9 Melanoma; CESC cis rs2011503 1.000 rs11670687 chr19:19621752 A/G cg11584989 chr19:19387371 SF4 0.61 7.06 0.4 1.45e-11 Bipolar disorder; CESC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg26818010 chr10:134567672 INPP5A -0.91 -11.21 -0.57 3.85e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC trans rs7980799 0.935 rs12301124 chr12:33543024 T/C cg26384229 chr12:38710491 ALG10B -0.5 -6.73 -0.38 1.03e-10 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg14416269 chr4:6271139 WFS1 0.47 7.95 0.44 5.57e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC trans rs17685 0.725 rs1044483 chr7:75659815 T/C cg19862616 chr7:65841803 NCRNA00174 -0.81 -11.47 -0.58 5.47e-25 Coffee consumption;Coffee consumption (cups per day); CESC cis rs9436747 0.605 rs7526141 chr1:65975275 C/T cg14976592 chr1:65886160 LEPROT;LEPR -0.43 -5.26 -0.31 3e-7 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; CESC cis rs2749592 0.611 rs2505199 chr10:38392457 G/A cg25427524 chr10:38739819 LOC399744 -0.62 -8.3 -0.45 5.37e-15 Age-related hearing impairment (SNP x SNP interaction); CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15202251 chr7:100183972 FBXO24;LRCH4 -0.47 -6.35 -0.36 9.52e-10 Asthma; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg14546197 chr17:38137043 PSMD3 -0.49 -6.44 -0.37 5.47e-10 Ulcerative colitis; CESC cis rs8017423 0.608 rs12589866 chr14:90820977 T/C cg14092571 chr14:90743983 NA 0.44 6.6 0.38 2.22e-10 Mortality in heart failure; CESC cis rs7937682 0.632 rs10891294 chr11:111699224 C/T cg22437258 chr11:111473054 SIK2 -0.52 -5.75 -0.33 2.48e-8 Primary sclerosing cholangitis; CESC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg17949981 chr6:28129498 ZNF389 0.46 5.51 0.32 8.48e-8 Depression; CESC cis rs2933343 0.951 rs7648327 chr3:128570708 A/G cg25356066 chr3:128598488 ACAD9 0.55 7.04 0.4 1.64e-11 IgG glycosylation; CESC cis rs2439831 0.764 rs2447193 chr15:43929733 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.81 8.43 0.46 2.26e-15 Lung cancer in ever smokers; CESC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg12311346 chr5:56204834 C5orf35 -0.74 -8.77 -0.47 2.29e-16 Initial pursuit acceleration; CESC cis rs11758351 0.660 rs16891446 chr6:26226996 A/C cg23601095 chr6:26197514 HIST1H3D 0.91 9.96 0.52 4.64e-20 Gout;Renal underexcretion gout; CESC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg23034840 chr1:205782522 SLC41A1 0.54 6.07 0.35 4.46e-9 Menarche (age at onset); CESC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg21782813 chr7:2030301 MAD1L1 0.38 5.26 0.31 2.99e-7 Bipolar disorder and schizophrenia; CESC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg17179057 chr10:14884691 HSPA14 0.42 6.39 0.37 7.46e-10 Thyroid stimulating hormone; CESC cis rs2180341 1.000 rs9375499 chr6:127618072 T/C cg24812749 chr6:127587940 RNF146 1.06 15.35 0.69 1.74e-38 Breast cancer; CESC trans rs10506458 1.000 rs11174759 chr12:63444363 A/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.32 -17.48 -0.73 4.95e-46 Hemostatic factors and hematological phenotypes; CESC cis rs2439831 0.867 rs3213990 chr15:43670226 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.86 12.85 0.62 1.02e-29 Lung cancer in ever smokers; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18905668 chr11:18388147 GTF2H1 0.43 6.3 0.36 1.21e-9 Fibrinogen levels; CESC trans rs11098499 0.661 rs10015965 chr4:120268237 A/G cg25214090 chr10:38739885 LOC399744 0.59 8.11 0.45 1.88e-14 Corneal astigmatism; CESC cis rs17407555 0.865 rs78272916 chr4:10286838 A/G cg11266682 chr4:10021025 SLC2A9 -0.45 -5.16 -0.3 4.78e-7 Schizophrenia (age at onset); CESC cis rs4664293 0.967 rs7590607 chr2:160545635 T/C cg08347373 chr2:160653686 CD302 -0.31 -5.13 -0.3 5.61e-7 Monocyte percentage of white cells; CESC cis rs67311347 1.000 rs9968170 chr3:40494274 A/G cg24209194 chr3:40518798 ZNF619 -0.46 -5.88 -0.34 1.23e-8 Renal cell carcinoma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18262260 chr14:89029717 ZC3H14 0.58 6.85 0.39 5e-11 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg07701084 chr6:150067640 NUP43 0.39 5.11 0.3 6.19e-7 Lung cancer; CESC cis rs9831754 0.906 rs9869812 chr3:78385679 G/A cg06138941 chr3:78371609 NA -0.66 -7.76 -0.43 1.88e-13 Calcium levels; CESC cis rs4308124 0.708 rs28766030 chr2:111962429 T/C cg04571233 chr2:111982156 NA -0.64 -7.06 -0.4 1.47e-11 Vitiligo; CESC trans rs561341 1.000 rs498391 chr17:30328704 G/A cg27661571 chr11:113659931 NA -0.77 -7.23 -0.41 5.19e-12 Hip circumference adjusted for BMI; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg05267963 chr11:63952891 STIP1 -0.42 -6.02 -0.35 5.86e-9 Gambling; CESC cis rs208520 0.909 rs55813840 chr6:67012508 A/C cg07460842 chr6:66804631 NA 0.84 8.13 0.45 1.67e-14 Exhaled nitric oxide output; CESC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg04369109 chr6:150039330 LATS1 -0.39 -5.44 -0.32 1.23e-7 Lung cancer; CESC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg04414720 chr1:150670196 GOLPH3L 0.62 8.8 0.48 1.76e-16 Tonsillectomy; CESC cis rs17253792 0.818 rs78393484 chr14:56065802 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.62 0.33 4.81e-8 Putamen volume; CESC cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg16339924 chr4:17578868 LAP3 0.59 7.41 0.41 1.69e-12 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6061231 1.000 rs13043313 chr20:60958269 A/G cg22601191 chr20:60968625 CABLES2 0.4 5.29 0.31 2.55e-7 Colorectal cancer; CESC cis rs2635047 0.783 rs9952447 chr18:44784700 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 5.63 0.33 4.52e-8 Educational attainment; CESC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 10.07 0.53 2.04e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19558503 chr7:30068084 PLEKHA8 0.57 6.47 0.37 4.62e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.58 -6.4 -0.37 6.83e-10 Gut microbiome composition (summer); CESC cis rs9814567 1.000 rs4417907 chr3:134291363 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.47 -6.36 -0.36 8.57e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg21285383 chr16:89894308 SPIRE2 0.3 5.31 0.31 2.37e-7 Vitiligo; CESC cis rs61931739 0.517 rs7486246 chr12:34526419 T/G cg06521331 chr12:34319734 NA -0.37 -5.15 -0.3 5.19e-7 Morning vs. evening chronotype; CESC cis rs2228479 0.850 rs2286393 chr16:89809548 C/A cg04013166 chr16:89971882 TCF25 0.74 6.51 0.37 3.73e-10 Skin colour saturation; CESC cis rs7084402 0.967 rs1303970 chr10:60298477 G/T cg07615347 chr10:60278583 BICC1 0.61 9.68 0.51 3.64e-19 Refractive error; CESC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.81 10.83 0.55 6.96e-23 Height; CESC cis rs7827545 0.545 rs6998092 chr8:135557449 A/G cg17885191 chr8:135476712 NA 0.5 5.47 0.32 1.04e-7 Hypertension (SNP x SNP interaction); CESC cis rs950169 0.881 rs62029599 chr15:84956565 A/C cg17507749 chr15:85114479 UBE2QP1 0.59 6.54 0.37 3.11e-10 Schizophrenia; CESC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg20891558 chr2:74357851 NA 0.81 11.86 0.59 2.57e-26 Gestational age at birth (maternal effect); CESC cis rs600231 0.554 rs1346 chr11:65337251 A/T cg17120908 chr11:65337727 SSSCA1 -0.73 -6.44 -0.37 5.62e-10 Bone mineral density; CESC cis rs77106637 0.556 rs7123876 chr11:72444583 T/C cg03713592 chr11:72463424 ARAP1 0.65 7.27 0.41 4.03e-12 Type 2 diabetes; CESC cis rs9399137 0.507 rs13214669 chr6:135299959 T/C cg22676075 chr6:135203613 NA 0.56 7.31 0.41 3.21e-12 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC trans rs11098499 0.779 rs7356491 chr4:120381974 C/T cg25214090 chr10:38739885 LOC399744 0.7 9.91 0.52 6.89e-20 Corneal astigmatism; CESC cis rs826838 1.000 rs11183160 chr12:38676702 T/C cg13010199 chr12:38710504 ALG10B 0.62 8.86 0.48 1.23e-16 Heart rate; CESC cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.54 7.54 0.42 7.31e-13 Personality dimensions; CESC cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg24130564 chr14:104152367 KLC1 -0.5 -6.58 -0.37 2.48e-10 Reticulocyte count; CESC cis rs4972806 0.849 rs2857541 chr2:177029086 C/T cg14324370 chr2:177042789 NA 0.43 6.15 0.35 2.87e-9 IgG glycosylation; CESC cis rs1801251 1.000 rs991873 chr2:233711046 A/G cg08000102 chr2:233561755 GIGYF2 -0.7 -10.11 -0.53 1.59e-20 Coronary artery disease; CESC cis rs2243480 1.000 rs160634 chr7:65528664 C/T cg13147721 chr7:65941812 NA 0.79 8.28 0.45 5.97e-15 Diabetic kidney disease; CESC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg07507251 chr3:52567010 NT5DC2 0.32 5.5 0.32 8.74e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15471079 chr4:89378292 HERC5 0.56 6.13 0.35 3.16e-9 Gut microbiome composition (summer); CESC cis rs2228479 0.867 rs12930606 chr16:89946682 A/G cg06558623 chr16:89946397 TCF25 1.06 8.98 0.48 5.17e-17 Skin colour saturation; CESC cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg11952622 chr19:58962976 ZNF324B 0.47 6.43 0.37 5.9e-10 Uric acid clearance; CESC cis rs77633900 0.803 rs2469215 chr15:76611933 C/T cg09663584 chr15:77347405 TSPAN3 0.59 5.17 0.3 4.57e-7 Non-glioblastoma glioma;Glioma; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg25850181 chr2:241992580 SNED1 0.44 6.08 0.35 4.26e-9 Fibrinogen levels; CESC cis rs7116495 0.737 rs7126838 chr11:71826237 A/G cg26138937 chr11:71823887 C11orf51 0.77 6.41 0.37 6.71e-10 Severe influenza A (H1N1) infection; CESC cis rs2742234 0.578 rs2435354 chr10:43652445 C/T cg07801480 chr10:43725741 RASGEF1A 0.45 5.68 0.33 3.63e-8 Hirschsprung disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02199589 chr7:77428242 PHTF2;TMEM60 0.51 6.14 0.35 3.03e-9 Gut microbiome composition (summer); CESC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.74 6.64 0.38 1.75e-10 Platelet count; CESC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.65 9.04 0.49 3.33e-17 Menopause (age at onset); CESC cis rs3768617 0.510 rs20557 chr1:183093875 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg04025307 chr7:1156635 C7orf50 0.48 7.76 0.43 1.89e-13 Longevity;Endometriosis; CESC cis rs1372520 0.766 rs2583961 chr4:90779758 A/G cg15133208 chr4:90757351 SNCA -0.35 -5.03 -0.3 8.84e-7 Neuroticism; CESC trans rs3808502 0.647 rs7821302 chr8:11236572 T/A cg06636001 chr8:8085503 FLJ10661 -0.49 -6.15 -0.35 2.9e-9 Neuroticism; CESC cis rs4595586 0.870 rs7962363 chr12:39299703 C/T cg26384229 chr12:38710491 ALG10B -0.39 -5.55 -0.32 6.87e-8 Morning vs. evening chronotype; CESC cis rs473651 0.935 rs515412 chr2:239345394 A/T cg18131467 chr2:239335373 ASB1 0.97 18.59 0.75 5.96e-50 Multiple system atrophy; CESC trans rs6445797 0.603 rs11130536 chr3:56668522 C/T cg15444621 chr13:113611794 NA 0.34 6.08 0.35 4.13e-9 Gastritis; CESC trans rs11165623 0.792 rs1125358 chr1:96971800 T/C cg10631902 chr5:14652156 NA -0.5 -7.39 -0.41 1.98e-12 Hip circumference;Waist circumference; CESC cis rs7927771 1.000 rs34128973 chr11:47851376 C/T cg20307385 chr11:47447363 PSMC3 -0.5 -6.05 -0.35 4.98e-9 Subjective well-being; CESC cis rs35955747 0.659 rs11704494 chr22:31913271 G/A cg25791279 chr22:32026902 PISD -0.44 -5.26 -0.31 2.98e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs7582720 1.000 rs116678869 chr2:203819471 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.36 0.41 2.34e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22517552 chr7:30518520 NOD1 0.58 6.29 0.36 1.32e-9 Gut microbiome composition (summer); CESC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.61 5.89 0.34 1.14e-8 Cerebrospinal P-tau181p levels; CESC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg07308232 chr7:1071921 C7orf50 -0.5 -7.01 -0.4 1.95e-11 Longevity;Endometriosis; CESC trans rs7866350 0.604 rs1935389 chr9:100994470 A/G cg08448040 chr3:13521693 HDAC11 0.47 6.03 0.35 5.45e-9 Post-traumatic stress disorder; CESC cis rs752010 0.808 rs7529858 chr1:42086606 G/C cg06885757 chr1:42089581 HIVEP3 0.51 8.84 0.48 1.39e-16 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18530716 chr17:6947403 SLC16A11 -0.54 -6.15 -0.35 2.82e-9 Gut microbiome composition (summer); CESC cis rs6775745 0.654 rs10470323 chr3:131784987 C/T cg12213930 chr3:131751605 CPNE4 0.47 5.38 0.31 1.61e-7 Neutrophil count; CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg15112475 chr7:1198522 ZFAND2A -0.39 -6.33 -0.36 1.03e-9 Longevity;Endometriosis; CESC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg18758796 chr5:131593413 PDLIM4 0.38 5.17 0.3 4.69e-7 Blood metabolite levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17818798 chr19:14228473 PRKACA 0.56 6.98 0.39 2.39e-11 Gut microbiome composition (summer); CESC cis rs8017423 0.935 rs59444150 chr14:90767175 T/C cg14092571 chr14:90743983 NA -0.57 -8.47 -0.46 1.71e-15 Mortality in heart failure; CESC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.32 -5.32 -0.31 2.25e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs3924048 0.559 rs4075303 chr1:12626593 C/G cg00291366 chr1:12616550 NA 0.37 6.44 0.37 5.6e-10 Optic cup area; CESC cis rs9527 0.567 rs6584539 chr10:104879402 G/C cg04362960 chr10:104952993 NT5C2 0.44 5.54 0.32 7.12e-8 Arsenic metabolism; CESC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg27170947 chr2:26402098 FAM59B -0.6 -7.18 -0.4 7.06e-12 Gut microbiome composition (summer); CESC cis rs11122272 0.735 rs2749723 chr1:231493302 A/G cg06096015 chr1:231504339 EGLN1 0.44 6.43 0.37 5.89e-10 Hemoglobin concentration; CESC cis rs3815700 1.000 rs7260624 chr19:33096562 A/G cg24916020 chr19:33096688 ANKRD27 0.6 6.04 0.35 5.09e-9 Eosinophilic esophagitis; CESC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg08736216 chr1:53307985 ZYG11A 0.42 7.11 0.4 1.06e-11 Monocyte count; CESC cis rs7605378 1.000 rs769957 chr2:200695524 A/C cg23649088 chr2:200775458 C2orf69 0.51 6.77 0.38 8.4e-11 Osteoporosis; CESC cis rs7129220 0.588 rs34984386 chr11:10095987 A/C cg01453529 chr11:10209919 SBF2 -0.47 -5.31 -0.31 2.32e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7395581 0.877 rs10838691 chr11:47341729 T/C cg25783544 chr11:47291846 MADD 0.59 7.72 0.43 2.45e-13 HDL cholesterol; CESC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.32 0.31 2.16e-7 Colonoscopy-negative controls vs population controls; CESC cis rs11122272 0.735 rs2572248 chr1:231514942 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs916888 0.773 rs199439 chr17:44793503 A/G cg17911788 chr17:44343683 NA -0.62 -8.21 -0.45 9.49e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3820068 0.532 rs78917815 chr1:15920821 A/G cg13390004 chr1:15929781 NA 0.33 5.04 0.3 8.45e-7 Systolic blood pressure; CESC cis rs7917772 0.503 rs7914389 chr10:104295402 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.17 0.3 4.66e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs644799 0.930 rs631099 chr11:95563482 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.55 6.76 0.38 8.51e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs8005677 1.000 rs7145494 chr14:23399790 T/C cg25600027 chr14:23388339 RBM23 -0.44 -5.37 -0.31 1.69e-7 Cognitive ability (multi-trait analysis); CESC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg18099408 chr3:52552593 STAB1 0.34 5.35 0.31 1.86e-7 Bipolar disorder; CESC cis rs6009527 0.752 rs7288176 chr22:49568462 A/G cg12746016 chr22:49560550 NA -0.43 -7.37 -0.41 2.24e-12 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); CESC cis rs55788414 0.932 rs9921666 chr16:81181669 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -7.04 -0.4 1.62e-11 Left ventricular obstructive tract defect (maternal effect); CESC cis rs2228479 0.702 rs62052710 chr16:89854893 C/T cg14709524 chr16:89940631 TCF25 0.94 7.06 0.4 1.5e-11 Skin colour saturation; CESC cis rs3760982 0.585 rs11083724 chr19:44298988 A/G cg11993925 chr19:44307056 LYPD5 0.34 5.85 0.34 1.45e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC cis rs2249694 0.960 rs7084384 chr10:135412322 A/G cg19469447 chr10:135341870 CYP2E1 0.36 5.09 0.3 6.96e-7 Obesity-related traits; CESC trans rs7672847 0.547 rs72973032 chr4:170368547 A/G cg19308436 chr1:237949471 RYR2 0.6 6.27 0.36 1.46e-9 Subjective well-being; CESC cis rs1707322 0.717 rs1547925 chr1:46085356 C/T cg06784218 chr1:46089804 CCDC17 -0.41 -7.25 -0.41 4.45e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs2180341 0.920 rs6916990 chr6:127698759 G/A cg27446573 chr6:127587934 RNF146 1.05 15.29 0.68 2.96e-38 Breast cancer; CESC cis rs2644899 0.750 rs2607424 chr19:41275147 C/T cg24958765 chr19:41283667 RAB4B -0.56 -6.53 -0.37 3.4e-10 Post bronchodilator FEV1/FVC ratio; CESC cis rs561341 0.783 rs512698 chr17:30292507 G/T cg23018236 chr17:30244563 NA -0.52 -5.07 -0.3 7.62e-7 Hip circumference adjusted for BMI; CESC cis rs2425143 1.000 rs6060578 chr20:34305445 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.82 -7.62 -0.42 4.5e-13 Blood protein levels; CESC cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg25427524 chr10:38739819 LOC399744 -0.66 -9.5 -0.5 1.29e-18 Extrinsic epigenetic age acceleration; CESC cis rs7149337 0.836 rs11622116 chr14:51670744 C/T cg23942311 chr14:51606299 NA 0.44 7.4 0.41 1.76e-12 Cancer; CESC cis rs12142240 0.698 rs56130131 chr1:46861306 A/C cg00530320 chr1:46809349 NSUN4 0.6 8.23 0.45 8.35e-15 Menopause (age at onset); CESC cis rs1215050 0.791 rs6838628 chr4:98809574 A/G cg05340658 chr4:99064831 C4orf37 0.54 7.13 0.4 9.4e-12 Waist-to-hip ratio adjusted for body mass index; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09556632 chr1:40839764 SMAP2 -0.5 -7.15 -0.4 8.56e-12 Fibrinogen levels; CESC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg11890956 chr21:40555474 PSMG1 1.11 18.04 0.74 5.19e-48 Cognitive function; CESC cis rs2228479 0.681 rs10153055 chr16:89965842 C/T cg06558623 chr16:89946397 TCF25 0.62 6.19 0.36 2.29e-9 Skin colour saturation; CESC cis rs1707322 0.752 rs4660880 chr1:46111040 C/T cg06784218 chr1:46089804 CCDC17 0.41 7.24 0.41 4.85e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg04366385 chr4:78980382 FRAS1 0.48 6.24 0.36 1.74e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs13108904 0.967 rs900029 chr4:1279145 C/T cg22903657 chr4:1355424 KIAA1530 -0.38 -5.17 -0.3 4.56e-7 Obesity-related traits; CESC cis rs6504663 0.558 rs11871603 chr17:48559037 T/G cg03168497 chr17:48586147 MYCBPAP 0.49 5.91 0.34 1.05e-8 Visceral fat; CESC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.1 -12.68 -0.61 4e-29 Gut microbiome composition (summer); CESC cis rs6933660 0.683 rs8180642 chr6:151756612 A/G cg02564969 chr6:151773285 C6orf211;RMND1 0.6 8.16 0.45 1.38e-14 Menarche (age at onset); CESC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg11301795 chr4:187892539 NA -0.75 -12.33 -0.6 6.74e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7772486 0.790 rs9376970 chr6:146241472 A/C cg23711669 chr6:146136114 FBXO30 -0.93 -14.33 -0.66 6.91e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs6540559 0.673 rs6698154 chr1:210007777 A/G cg22029157 chr1:209979665 IRF6 0.7 7.81 0.43 1.36e-13 Cleft lip with or without cleft palate; CESC cis rs7408868 1.000 rs10415431 chr19:15277027 G/A cg14696996 chr19:15285081 NOTCH3 1.11 11.51 0.58 3.92e-25 Pulse pressure; CESC cis rs8064100 0.526 rs8045545 chr16:56730361 C/G cg01055000 chr16:56763872 NUP93 -0.35 -5.14 -0.3 5.25e-7 Gambling; CESC cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg24308560 chr3:49941425 MST1R 0.61 8.83 0.48 1.49e-16 Intelligence (multi-trait analysis); CESC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg14703610 chr5:56206110 C5orf35 0.53 6.94 0.39 3e-11 Coronary artery disease; CESC trans rs11148252 0.557 rs9536223 chr13:53233194 A/T cg18335740 chr13:41363409 SLC25A15 0.52 7.02 0.4 1.89e-11 Lewy body disease; CESC cis rs7726839 0.526 rs11960159 chr5:568685 C/T cg09021430 chr5:549028 NA -0.46 -6.33 -0.36 1.04e-9 Obesity-related traits; CESC cis rs2832191 0.671 rs2832213 chr21:30512914 A/G cg24692254 chr21:30365293 RNF160 -0.61 -7.74 -0.43 2.16e-13 Dental caries; CESC cis rs4808199 0.948 rs2074301 chr19:19381715 G/A cg03709012 chr19:19516395 GATAD2A 1.09 12.01 0.59 7.83e-27 Nonalcoholic fatty liver disease; CESC cis rs16854884 1.000 rs11924473 chr3:143787075 C/G cg06585982 chr3:143692056 C3orf58 0.44 5.08 0.3 7.07e-7 Economic and political preferences (feminism/equality); CESC cis rs7666738 0.791 rs62318641 chr4:98816964 T/C cg05340658 chr4:99064831 C4orf37 0.7 9.81 0.52 1.38e-19 Colonoscopy-negative controls vs population controls; CESC cis rs2072499 0.778 rs2842868 chr1:156196407 A/C cg24450063 chr1:156163899 SLC25A44 0.86 11.49 0.58 4.77e-25 Testicular germ cell tumor; CESC cis rs1062177 0.826 rs2915879 chr5:151147442 A/G cg12924095 chr5:151150029 G3BP1 0.42 5.55 0.32 6.93e-8 Preschool internalizing problems; CESC trans rs3857536 0.566 rs208463 chr6:66913962 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.56 -6.71 -0.38 1.21e-10 Blood trace element (Cu levels); CESC cis rs3540 0.553 rs4031431 chr15:90990782 G/T cg10434728 chr15:90938212 IQGAP1 0.41 7.38 0.41 2.03e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs7592578 0.771 rs10432434 chr2:191387079 T/G cg10560079 chr2:191398806 TMEM194B -0.69 -6.18 -0.35 2.39e-9 Diastolic blood pressure; CESC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg11317459 chr13:21872234 NA 1.21 15.32 0.69 2.21e-38 White matter hyperintensity burden; CESC trans rs11098499 0.690 rs34818745 chr4:120257055 T/C cg25214090 chr10:38739885 LOC399744 0.67 9.15 0.49 1.54e-17 Corneal astigmatism; CESC trans rs2727020 0.658 rs4980442 chr11:49445016 G/T cg03929089 chr4:120376271 NA -0.81 -12.62 -0.61 6.51e-29 Coronary artery disease; CESC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg16325326 chr1:53192061 ZYG11B -0.61 -9.42 -0.5 2.35e-18 Monocyte count; CESC cis rs7208859 0.623 rs11651857 chr17:28926362 G/T cg14008862 chr17:28927542 LRRC37B2 0.73 5.52 0.32 8.23e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs12701220 0.817 rs1058727 chr7:1087095 A/G cg26769984 chr7:1090371 C7orf50 0.54 6.54 0.37 3.14e-10 Bronchopulmonary dysplasia; CESC cis rs2820292 1.000 rs1032524 chr1:201790826 C/T cg11586189 chr1:201857591 SHISA4 -0.32 -5.38 -0.31 1.65e-7 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC trans rs208520 0.526 rs9354370 chr6:66808209 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.11 23.98 0.83 2.35e-68 Exhaled nitric oxide output; CESC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg13777783 chr17:79615861 NA -0.35 -5.79 -0.34 1.99e-8 Eye color traits; CESC cis rs7945705 0.967 rs10840148 chr11:8923528 C/T cg12365402 chr11:9010492 NRIP3 0.4 6.09 0.35 3.86e-9 Hemoglobin concentration; CESC cis rs76878669 0.561 rs10896112 chr11:66116836 G/C cg18002602 chr11:66138449 SLC29A2 -0.41 -6.77 -0.38 8.14e-11 Educational attainment (years of education); CESC cis rs2404602 0.692 rs7169663 chr15:77192843 A/C cg26408565 chr15:76604113 ETFA -0.39 -5.67 -0.33 3.72e-8 Blood metabolite levels; CESC cis rs4253772 0.938 rs41371446 chr22:46637272 T/C cg00784671 chr22:46762841 CELSR1 -0.57 -5.63 -0.33 4.54e-8 LDL cholesterol;Cholesterol, total; CESC cis rs9560113 0.622 rs4773388 chr13:112195250 A/C cg10483660 chr13:112241077 NA 0.37 6.15 0.35 2.92e-9 Menarche (age at onset); CESC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg02592271 chr2:27665507 KRTCAP3 -0.29 -5.79 -0.34 2e-8 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13561339 chr22:27282899 NA -0.58 -7.09 -0.4 1.2e-11 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg18180107 chr4:99064573 C4orf37 0.42 5.43 0.32 1.29e-7 Colonoscopy-negative controls vs population controls; CESC trans rs116095464 0.558 rs10057299 chr5:242135 C/T cg00938859 chr5:1591904 SDHAP3 0.64 6.98 0.39 2.36e-11 Breast cancer; CESC cis rs5758659 1.000 rs134902 chr22:42683997 C/T cg15557168 chr22:42548783 NA -0.44 -7.2 -0.4 6.16e-12 Cognitive function; CESC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg26314531 chr2:26401878 FAM59B -0.61 -6.86 -0.39 4.88e-11 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21830805 chr14:91087524 TTC7B 0.44 6.16 0.35 2.7e-9 Fibrinogen levels; CESC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg08027265 chr7:2291960 NA -0.43 -6.62 -0.38 1.94e-10 Schizophrenia; CESC cis rs870825 0.556 rs6552811 chr4:185653351 T/A cg04058563 chr4:185651563 MLF1IP -0.63 -6.94 -0.39 3.04e-11 Blood protein levels; CESC cis rs116095464 0.558 rs10475136 chr5:232796 A/G cg22857025 chr5:266934 NA -1.29 -18.24 -0.75 1.01e-48 Breast cancer; CESC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg07636037 chr3:49044803 WDR6 -0.82 -14.18 -0.66 2.46e-34 Menarche (age at onset); CESC cis rs2249625 0.874 rs1852705 chr6:72875512 G/T cg18830697 chr6:72922368 RIMS1 -0.43 -6.23 -0.36 1.85e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs748404 0.697 rs513970 chr15:43579566 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.59 7.88 0.44 8.43e-14 Lung cancer; CESC cis rs478222 1.000 rs478222 chr2:25301755 A/T cg01884057 chr2:25150051 NA -0.32 -5.54 -0.32 7.11e-8 Type 1 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12314527 chr22:19110193 DGCR2 0.56 6.33 0.36 1.02e-9 Gut microbiome composition (summer); CESC cis rs846111 1.000 rs846111 chr1:6279370 G/C cg15892785 chr1:6309343 GPR153 -0.68 -8.39 -0.46 2.89e-15 QT interval; CESC cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.4 0.46 2.66e-15 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg26338869 chr17:61819248 STRADA 0.72 9.35 0.5 3.89e-18 Prudent dietary pattern; CESC cis rs10129255 0.957 rs10142918 chr14:107190443 C/A cg23076370 chr14:107095027 NA -0.46 -5.79 -0.34 1.96e-8 Kawasaki disease; CESC cis rs2439831 0.867 rs2264876 chr15:43757419 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.57 0.54 5.08e-22 Lung cancer in ever smokers; CESC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg05332525 chr7:65337924 VKORC1L1 0.52 6.28 0.36 1.36e-9 Aortic root size; CESC cis rs2276314 0.857 rs6507157 chr18:33631703 A/C cg19628046 chr18:33552617 C18orf21 0.5 5.49 0.32 9.61e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7208859 0.623 rs58089675 chr17:29196764 C/G cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg11905131 chr22:24372483 LOC391322 0.72 10.6 0.55 3.98e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3820068 0.581 rs34453754 chr1:15993208 G/C cg17385448 chr1:15911702 AGMAT 0.45 7.37 0.41 2.21e-12 Systolic blood pressure; CESC cis rs72781680 0.566 rs6713865 chr2:23899807 A/G cg20701182 chr2:24300061 SF3B14 0.71 7.18 0.4 7.24e-12 Lymphocyte counts; CESC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg07701084 chr6:150067640 NUP43 0.44 6.04 0.35 5.26e-9 Lung cancer; CESC cis rs3947 0.789 rs8005 chr8:11701096 A/C cg00262122 chr8:11665843 FDFT1 0.55 6.55 0.37 3e-10 Blood protein levels; CESC cis rs911555 0.692 rs7140647 chr14:103893465 A/G cg12935359 chr14:103987150 CKB 0.63 9.4 0.5 2.68e-18 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26599274 chr7:66205733 RABGEF1 0.63 6.85 0.39 5.28e-11 Gut microbiome composition (summer); CESC cis rs6665290 0.868 rs2183836 chr1:227199404 A/T cg10327440 chr1:227177885 CDC42BPA -1.21 -29.63 -0.88 4.28e-86 Myeloid white cell count; CESC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg25985355 chr7:65971099 NA 0.32 5.23 0.31 3.53e-7 Aortic root size; CESC cis rs17376456 0.825 rs6877030 chr5:93201841 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.37 0.31 1.74e-7 Diabetic retinopathy; CESC cis rs2832191 0.791 rs2832179 chr21:30480366 C/T cg24692254 chr21:30365293 RNF160 -0.8 -12.52 -0.61 1.4e-28 Dental caries; CESC cis rs1451375 0.572 rs66792686 chr7:50651239 T/C cg14593290 chr7:50529359 DDC 0.44 5.29 0.31 2.55e-7 Malaria; CESC cis rs644799 0.965 rs573758 chr11:95539591 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.7 9.15 0.49 1.61e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.6 7.83 0.43 1.17e-13 Prudent dietary pattern; CESC cis rs1878931 0.501 rs4785934 chr16:3419934 G/T cg22508957 chr16:3507546 NAT15 -0.38 -5.5 -0.32 9.16e-8 Body mass index (adult); CESC cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.52 0.61 1.45e-28 Colonoscopy-negative controls vs population controls; CESC cis rs10949834 0.793 rs810534 chr7:73505045 A/G cg07137043 chr7:73588983 EIF4H 0.69 7.52 0.42 8.28e-13 Verbal memory performance (residualized delayed recall change); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06558623 chr16:89946397 TCF25 -0.57 -6.62 -0.38 1.94e-10 Gut microbiome composition (summer); CESC cis rs2180341 0.814 rs9401958 chr6:127736357 T/G cg24812749 chr6:127587940 RNF146 0.84 12.05 0.59 5.93e-27 Breast cancer; CESC cis rs9815354 0.680 rs115754309 chr3:42017246 A/G cg03022575 chr3:42003672 ULK4 0.74 6.64 0.38 1.79e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs9715521 0.868 rs6856620 chr4:59820960 A/G cg11281224 chr4:60001000 NA -0.52 -6.68 -0.38 1.4e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg05283184 chr6:79620031 NA -0.44 -6.75 -0.38 9.41e-11 Intelligence (multi-trait analysis); CESC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg16006841 chr5:176797999 RGS14 0.43 5.17 0.3 4.68e-7 Hemoglobin concentration;Hematocrit; CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg01092528 chr4:76861103 NAAA -0.45 -6.22 -0.36 1.96e-9 Height; CESC cis rs7149242 0.961 rs7142683 chr14:101158882 A/G cg18089426 chr14:101175970 NA -0.36 -5.92 -0.34 9.74e-9 Platelet count; CESC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg05368731 chr17:41323189 NBR1 0.8 10.6 0.55 4.09e-22 Menopause (age at onset); CESC cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg00701064 chr4:6280414 WFS1 0.73 12.79 0.62 1.69e-29 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg22920501 chr2:26401640 FAM59B -0.91 -10.38 -0.54 2.08e-21 Gut microbiome composition (summer); CESC cis rs10416265 0.527 rs11084699 chr19:33538393 A/T cg03563238 chr19:33554763 RHPN2 -0.31 -5.56 -0.32 6.42e-8 Bone properties (heel); CESC cis rs684232 0.666 rs838371 chr17:609275 T/C cg15660573 chr17:549704 VPS53 -0.67 -9.32 -0.5 4.84e-18 Prostate cancer; CESC trans rs2727020 0.576 rs10839305 chr11:49598733 T/C cg15704280 chr7:45808275 SEPT13 -0.96 -17.33 -0.73 1.73e-45 Coronary artery disease; CESC cis rs1568889 0.887 rs7102237 chr11:28344296 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.82 13.94 0.65 1.67e-33 Bipolar disorder; CESC cis rs11122272 0.735 rs2486736 chr1:231521478 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.48 6.3 0.36 1.2e-9 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19721211 chr15:51058100 SPPL2A 0.58 6.77 0.38 8.48e-11 Gut microbiome composition (summer); CESC cis rs2997447 0.761 rs61776586 chr1:26438933 T/C cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.06 -0.3 7.76e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg14983838 chr19:29218262 NA 0.49 6.01 0.35 6.12e-9 Methadone dose in opioid dependence; CESC cis rs6460942 0.597 rs4721106 chr7:12535053 T/C cg02935154 chr7:12443704 VWDE -0.57 -5.7 -0.33 3.23e-8 Coronary artery disease; CESC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg05564831 chr3:52568323 NT5DC2 0.46 6.61 0.38 2.14e-10 Bipolar disorder; CESC cis rs7927771 0.965 rs12787112 chr11:47687147 A/G cg18512352 chr11:47633146 NA -0.6 -9.47 -0.5 1.58e-18 Subjective well-being; CESC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg25036284 chr2:26402008 FAM59B -0.61 -7.08 -0.4 1.31e-11 Gut microbiome composition (summer); CESC cis rs10870270 0.957 rs10870307 chr10:133780610 T/C cg08754478 chr10:133766260 PPP2R2D -0.59 -7.56 -0.42 6.51e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg24531977 chr5:56204891 C5orf35 -0.55 -7.25 -0.41 4.69e-12 Coronary artery disease; CESC cis rs4065321 0.522 rs3744245 chr17:38146542 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.6 8.97 0.48 5.57e-17 White blood cell count (basophil);White blood cell count; CESC cis rs7539409 0.915 rs1977119 chr1:84275509 A/G cg10977910 chr1:84465055 TTLL7 0.63 5.8 0.34 1.88e-8 Alzheimer's disease; CESC cis rs559928 0.606 rs60394481 chr11:63909035 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 6.06 0.35 4.55e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CESC cis rs12477438 0.798 rs1453562 chr2:99615850 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg21724239 chr8:58056113 NA 0.57 5.91 0.34 1.02e-8 Developmental language disorder (linguistic errors); CESC cis rs116095464 0.619 rs2303741 chr5:218356 T/C cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.74 0.33 2.63e-8 Breast cancer; CESC cis rs7208859 0.673 rs450585 chr17:28951039 G/A cg04154034 chr17:28927549 LRRC37B2 0.68 6.1 0.35 3.76e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7647973 0.925 rs9881860 chr3:49352522 A/T cg07636037 chr3:49044803 WDR6 0.66 8.85 0.48 1.27e-16 Menarche (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04436474 chr3:49977685 RBM6 0.5 6.44 0.37 5.55e-10 Gut microbiota (bacterial taxa); CESC cis rs7100689 0.599 rs7077847 chr10:82134952 A/G cg00277334 chr10:82204260 NA -0.58 -7.52 -0.42 8.77e-13 Post bronchodilator FEV1; CESC cis rs7651039 1.000 rs7651039 chr3:15648004 C/T cg16303742 chr3:15540471 COLQ -0.32 -5.03 -0.3 9e-7 Coronary heart disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06159435 chr11:118966351 H2AFX 0.6 7.05 0.4 1.55e-11 Gut microbiome composition (summer); CESC cis rs4803468 1.000 rs2569754 chr19:41936734 A/G cg09537434 chr19:41945824 ATP5SL -1.13 -21.98 -0.8 1.19e-61 Height; CESC cis rs7772486 0.875 rs2814866 chr6:146339414 C/A cg05347473 chr6:146136440 FBXO30 0.5 6.7 0.38 1.23e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs11642862 0.901 rs11642733 chr16:30969061 G/A cg02466173 chr16:30829666 NA -0.57 -5.21 -0.3 3.81e-7 Tonsillectomy; CESC cis rs8092503 1.000 rs12956208 chr18:52473167 C/T cg12377874 chr18:52495404 RAB27B 0.37 6.0 0.35 6.52e-9 Childhood body mass index; CESC cis rs9300255 0.602 rs1716172 chr12:123712712 G/T cg19016782 chr12:123741754 C12orf65 -0.47 -6.7 -0.38 1.26e-10 Neutrophil percentage of white cells; CESC trans rs12492269 0.702 rs41381644 chr3:178161614 A/G cg04062383 chr3:179370420 USP13 -0.7 -6.07 -0.35 4.45e-9 Plasma clusterin levels; CESC cis rs9486719 1.000 rs13207333 chr6:96882254 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -8.29 -0.45 5.61e-15 Migraine;Coronary artery disease; CESC cis rs7580658 0.891 rs55998967 chr2:128048674 A/C cg10021288 chr2:128175891 PROC -0.41 -6.53 -0.37 3.32e-10 Protein C levels; CESC cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg11644478 chr21:40555479 PSMG1 0.61 8.3 0.45 5.41e-15 Cognitive function; CESC cis rs6912958 0.559 rs451829 chr6:88041919 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.45 7.86 0.43 9.86e-14 Monocyte percentage of white cells; CESC trans rs2488397 0.750 rs6702421 chr1:197559324 C/T cg13426224 chr12:133196447 P2RX2 -0.46 -6.0 -0.35 6.37e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs11077998 0.840 rs9910991 chr17:80481193 G/A cg10255544 chr17:80519551 FOXK2 0.52 8.45 0.46 1.9e-15 Reticulocyte fraction of red cells; CESC cis rs854765 0.583 rs67253360 chr17:17828973 T/C cg04398451 chr17:18023971 MYO15A -0.67 -9.6 -0.51 6.42e-19 Total body bone mineral density; CESC cis rs60154123 0.730 rs588197 chr1:210463515 A/T cg22029157 chr1:209979665 IRF6 0.47 5.95 0.34 8.53e-9 Coronary artery disease; CESC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg13770153 chr20:60521292 NA -0.44 -5.7 -0.33 3.2e-8 Body mass index; CESC cis rs3092073 0.624 rs34293711 chr20:44587186 C/T cg17986701 chr20:44574422 PCIF1 0.34 5.31 0.31 2.27e-7 Intelligence (multi-trait analysis); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg12416067 chr10:70231662 DNA2 -0.48 -6.1 -0.35 3.79e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs11122272 0.735 rs2474630 chr1:231535335 G/A cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs7208859 0.623 rs9899692 chr17:29156939 C/T cg13385521 chr17:29058706 SUZ12P 0.75 6.0 0.35 6.29e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs7520050 0.966 rs12561806 chr1:46396776 C/T cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.66e-9 Red blood cell count;Reticulocyte count; CESC cis rs4660306 0.961 rs11211138 chr1:46015157 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.58 -7.11 -0.4 1.05e-11 Homocysteine levels; CESC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg10494973 chr17:80897199 TBCD -0.48 -6.0 -0.35 6.41e-9 Breast cancer; CESC cis rs2073300 1.000 rs12625804 chr20:23441981 G/A cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs10911232 0.507 rs10911196 chr1:182995233 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00529946 chr2:26568848 SELI;GPR113 0.58 6.85 0.39 5.14e-11 Gut microbiome composition (summer); CESC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg21280719 chr6:42927975 GNMT -0.27 -6.32 -0.36 1.07e-9 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1790761 0.505 rs2370141 chr11:67348529 A/G cg14500267 chr11:67383377 NA -0.31 -5.12 -0.3 5.81e-7 Mean corpuscular volume; CESC cis rs6582630 0.537 rs7310749 chr12:38400472 C/T cg26384229 chr12:38710491 ALG10B 0.72 11.03 0.56 1.58e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg22823121 chr1:150693482 HORMAD1 0.47 6.89 0.39 4.04e-11 Tonsillectomy; CESC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg24578937 chr1:2090814 PRKCZ 0.36 6.41 0.37 6.69e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09171577 chr7:150778137 FASTK -0.55 -6.39 -0.37 7.34e-10 Gut microbiome composition (summer); CESC cis rs67478160 0.619 rs12437066 chr14:104236844 A/C cg08213375 chr14:104286397 PPP1R13B 0.47 9.08 0.49 2.53e-17 Schizophrenia; CESC cis rs7666738 0.515 rs11733968 chr4:98906448 A/C cg17366294 chr4:99064904 C4orf37 -0.49 -6.56 -0.37 2.76e-10 Colonoscopy-negative controls vs population controls; CESC cis rs372883 0.600 rs2832293 chr21:30738872 C/G cg24692254 chr21:30365293 RNF160 0.57 7.15 0.4 8.65e-12 Pancreatic cancer; CESC cis rs9457247 1.000 rs400837 chr6:167411008 T/C cg07741184 chr6:167504864 NA 0.3 5.52 0.32 8.06e-8 Crohn's disease; CESC cis rs35995292 0.534 rs7793692 chr7:38940580 G/C cg19327137 chr7:38886074 VPS41 0.66 10.8 0.55 9.13e-23 Subjective well-being (multi-trait analysis); CESC cis rs35110281 0.805 rs2838319 chr21:44991901 A/G cg01579765 chr21:45077557 HSF2BP -0.58 -10.01 -0.52 3.14e-20 Mean corpuscular volume; CESC cis rs897984 0.806 rs8050588 chr16:30937799 G/A cg00531865 chr16:30841666 NA -0.51 -7.1 -0.4 1.12e-11 Dementia with Lewy bodies; CESC cis rs1881797 1.000 rs10158379 chr1:247686352 C/A cg11166453 chr1:247681781 NA 0.44 5.77 0.33 2.24e-8 Acute lymphoblastic leukemia (childhood); CESC trans rs7555006 0.671 rs11580026 chr1:51476003 A/T cg20701182 chr2:24300061 SF3B14 0.49 6.2 0.36 2.13e-9 Headache; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.53 -6.01 -0.35 6.18e-9 Gut microbiome composition (summer); CESC cis rs35955747 0.601 rs5749302 chr22:31950618 C/T cg25791279 chr22:32026902 PISD 0.44 5.16 0.3 4.91e-7 Neutrophil count;Sum basophil neutrophil counts; CESC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.69 0.43 2.83e-13 Prudent dietary pattern; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14475772 chr1:150207136 ANP32E -0.48 -7.87 -0.44 9.14e-14 Gambling; CESC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg11764359 chr7:65958608 NA -0.73 -10.48 -0.54 1.01e-21 Aortic root size; CESC cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 5.1 0.3 6.51e-7 Osteoporosis; CESC cis rs9322193 0.884 rs1108889 chr6:150166569 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.39 -0.31 1.56e-7 Lung cancer; CESC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg16325326 chr1:53192061 ZYG11B 0.86 14.92 0.68 6.06e-37 Monocyte count; CESC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg24675658 chr1:53192096 ZYG11B -0.55 -6.84 -0.39 5.33e-11 Monocyte count; CESC cis rs9837602 0.938 rs793457 chr3:99518987 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.56 -7.39 -0.41 1.89e-12 Breast cancer; CESC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10129255 0.500 rs10143385 chr14:107190796 G/A cg23076370 chr14:107095027 NA -0.65 -9.64 -0.51 4.66e-19 Kawasaki disease; CESC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg03934478 chr11:495069 RNH1 0.58 5.58 0.32 6.07e-8 Body mass index; CESC cis rs2795502 0.938 rs2744085 chr10:43341976 C/T cg27426351 chr10:43362370 NA 0.44 5.62 0.33 4.89e-8 Blood protein levels; CESC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg17971929 chr21:40555470 PSMG1 1.07 16.73 0.72 2.16e-43 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21983178 chr1:45120676 TMEM53 -0.58 -6.44 -0.37 5.73e-10 Gut microbiome composition (summer); CESC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg26338869 chr17:61819248 STRADA 0.69 9.1 0.49 2.2e-17 Prudent dietary pattern; CESC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg01448562 chr3:133502909 NA 0.42 5.89 0.34 1.14e-8 Iron status biomarkers; CESC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg21782813 chr7:2030301 MAD1L1 0.5 7.07 0.4 1.37e-11 Bipolar disorder and schizophrenia; CESC trans rs9850225 0.719 rs4856616 chr3:80466481 A/C cg13866129 chr11:62623438 SNORD27;SLC3A2;SNORD28;SNORD25;SNORD26;SNHG1 0.38 6.07 0.35 4.39e-9 Erectile dysfunction in type 1 diabetes; CESC cis rs9948 0.786 rs6756482 chr2:97458561 A/G cg01990225 chr2:97406019 LMAN2L -0.73 -6.8 -0.39 7.02e-11 Erectile dysfunction and prostate cancer treatment; CESC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg24846343 chr22:24311635 DDTL 0.66 11.43 0.57 7.31e-25 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10751667 0.666 rs7123912 chr11:963936 T/C cg01483505 chr11:975446 AP2A2 0.36 5.05 0.3 8.13e-7 Alzheimer's disease (late onset); CESC cis rs73110464 0.609 rs6580923 chr12:53358352 A/G cg05393297 chr12:53359155 NA -0.72 -10.41 -0.54 1.64e-21 Cancer (pleiotropy); CESC cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg22764044 chr5:178986830 RUFY1 0.45 6.78 0.38 7.76e-11 Lung cancer; CESC cis rs9393777 0.588 rs6926677 chr6:26478825 G/C cg12826209 chr6:26865740 GUSBL1 0.57 6.77 0.38 8.32e-11 Intelligence (multi-trait analysis); CESC cis rs9549260 0.755 rs7317254 chr13:41217849 A/G cg21288729 chr13:41239152 FOXO1 0.68 8.81 0.48 1.67e-16 Red blood cell count; CESC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.53 7.27 0.41 4.02e-12 Personality dimensions; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21194341 chr7:76256835 POMZP3;LOC100133091 -0.57 -6.3 -0.36 1.24e-9 Gut microbiome composition (summer); CESC cis rs9309711 0.883 rs13429373 chr2:3477014 G/A cg10845886 chr2:3471009 TTC15 -0.86 -12.03 -0.59 6.73e-27 Neurofibrillary tangles; CESC cis rs3820068 0.603 rs932602 chr1:15986087 A/G cg18133145 chr1:16060689 PLEKHM2 -0.39 -5.04 -0.3 8.55e-7 Systolic blood pressure; CESC cis rs3740713 1.000 rs57311859 chr11:18454410 A/C cg23797887 chr11:18477753 LDHAL6A -0.53 -5.27 -0.31 2.89e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs1008375 0.966 rs28441502 chr4:17598384 G/A cg04450456 chr4:17643702 FAM184B 0.36 5.04 0.3 8.73e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs79349575 0.783 rs17708633 chr17:47011620 C/G cg16584676 chr17:46985605 UBE2Z 0.54 6.67 0.38 1.46e-10 Type 2 diabetes; CESC cis rs3820928 0.904 rs59135978 chr2:227857763 T/C cg11843606 chr2:227700838 RHBDD1 -0.4 -5.1 -0.3 6.47e-7 Pulmonary function; CESC cis rs10883723 0.810 rs10786671 chr10:104271303 G/A cg22532475 chr10:104410764 TRIM8 -0.33 -5.68 -0.33 3.5e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 6.64 0.38 1.73e-10 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07518170 chr20:30865285 KIF3B 0.59 6.94 0.39 3.07e-11 Gut microbiome composition (summer); CESC cis rs17376456 0.741 rs12374432 chr5:93481348 C/A cg17533458 chr5:92956826 FAM172A;MIR2277 0.63 5.33 0.31 2.11e-7 Diabetic retinopathy; CESC cis rs6594499 0.872 rs6881147 chr5:110451936 G/C cg04022379 chr5:110408740 TSLP 0.32 5.63 0.33 4.49e-8 Allergic disease (asthma, hay fever or eczema); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03426840 chr11:118661678 DDX6 0.56 6.81 0.39 6.52e-11 Gut microbiome composition (summer); CESC cis rs3617 0.572 rs2256332 chr3:52855865 A/G cg07507251 chr3:52567010 NT5DC2 -0.31 -5.17 -0.3 4.62e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs7809950 1.000 rs987391 chr7:107100794 C/G cg23024343 chr7:107201750 COG5 -0.4 -5.65 -0.33 4.11e-8 Coronary artery disease; CESC cis rs2836974 0.931 rs2776309 chr21:40715791 A/G cg27266027 chr21:40555129 PSMG1 0.46 5.29 0.31 2.58e-7 Cognitive function; CESC trans rs7618501 0.633 rs9861216 chr3:50059339 A/G cg21659725 chr3:3221576 CRBN -0.48 -6.81 -0.39 6.52e-11 Intelligence (multi-trait analysis); CESC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg06456125 chr7:65229604 NA -0.48 -6.33 -0.36 1.04e-9 Aortic root size; CESC cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7568458 0.684 rs60012532 chr2:85752474 A/C cg02493740 chr2:85810744 VAMP5 -0.58 -8.46 -0.46 1.8e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs9911578 0.967 rs11079368 chr17:57086473 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.15 -0.3 4.97e-7 Intelligence (multi-trait analysis); CESC cis rs2839186 0.814 rs2276257 chr21:47711229 A/G cg10351095 chr21:47802916 PCNT -0.5 -6.78 -0.38 7.62e-11 Testicular germ cell tumor; CESC cis rs3091242 0.933 rs61775174 chr1:25787313 G/A cg02931644 chr1:25747376 RHCE -0.39 -6.44 -0.37 5.56e-10 Erythrocyte sedimentation rate; CESC trans rs60843830 0.964 rs62114538 chr2:256116 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 8.04 0.44 2.99e-14 Spherical equivalent (joint analysis main effects and education interaction); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg12317515 chr5:74063363 GFM2;NSA2 -0.42 -6.28 -0.36 1.42e-9 Vertical cup-disc ratio; CESC cis rs36051895 0.588 rs12340895 chr9:5076691 C/G cg02405213 chr9:5042618 JAK2 0.5 6.15 0.35 2.85e-9 Pediatric autoimmune diseases; CESC cis rs10411936 1.000 rs7256818 chr19:16558766 C/A cg10248733 chr19:16607483 C19orf44;CALR3 -0.54 -6.39 -0.37 7.33e-10 White blood cell count;Multiple sclerosis; CESC cis rs8070128 0.601 rs8080602 chr17:17954728 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.62 -8.81 -0.48 1.7e-16 Total body bone mineral density; CESC trans rs637571 0.584 rs594689 chr11:65635559 G/A cg17712092 chr4:129076599 LARP1B -0.67 -8.41 -0.46 2.64e-15 Eosinophil percentage of white cells; CESC cis rs10883723 0.810 rs7092622 chr10:104249919 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.44 0.42 1.43e-12 Allergic disease (asthma, hay fever or eczema); CESC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg22800045 chr5:56110881 MAP3K1 0.81 9.66 0.51 4.1e-19 Initial pursuit acceleration; CESC cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg03433033 chr1:76189801 ACADM 0.7 9.38 0.5 2.99e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs6545883 0.929 rs10200055 chr2:61628017 T/A cg15711740 chr2:61764176 XPO1 0.41 5.21 0.3 3.79e-7 Tuberculosis; CESC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg23978390 chr7:1156363 C7orf50 0.53 7.08 0.4 1.33e-11 Longevity;Endometriosis; CESC cis rs2486288 0.656 rs1719232 chr15:45572072 A/G cg09092052 chr15:45571596 NA 0.5 5.9 0.34 1.09e-8 Glomerular filtration rate; CESC cis rs4268898 0.697 rs6714652 chr2:24383059 C/T cg06627628 chr2:24431161 ITSN2 0.48 6.31 0.36 1.14e-9 Asthma; CESC cis rs4588572 0.644 rs7714871 chr5:77754268 G/T cg11547950 chr5:77652471 NA -0.4 -5.36 -0.31 1.84e-7 Triglycerides; CESC cis rs477692 0.837 rs543454 chr10:131420536 T/C cg05714579 chr10:131428358 MGMT 0.55 7.87 0.44 9.05e-14 Response to temozolomide; CESC cis rs1707322 0.721 rs6665808 chr1:46162283 C/T cg06784218 chr1:46089804 CCDC17 0.42 7.58 0.42 5.82e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 8.61 0.47 6.49e-16 Menopause (age at onset); CESC cis rs478304 0.651 rs11537193 chr11:65500003 A/C cg10518572 chr11:65560635 OVOL1 -0.33 -6.61 -0.38 2.09e-10 Acne (severe); CESC cis rs9512730 0.553 rs6491211 chr13:28049533 A/G cg08193333 chr13:27998609 GTF3A 0.45 5.54 0.32 7.27e-8 Schizophrenia; CESC cis rs897984 0.806 rs11150600 chr16:30940331 C/T cg00531865 chr16:30841666 NA 0.51 7.12 0.4 1.01e-11 Dementia with Lewy bodies; CESC cis rs12368653 0.693 rs2640610 chr12:58037435 T/A cg18357645 chr12:58087776 OS9 0.43 6.25 0.36 1.66e-9 Multiple sclerosis; CESC cis rs453301 0.658 rs13271797 chr8:8885954 G/A cg15556689 chr8:8085844 FLJ10661 -0.48 -5.91 -0.34 1.08e-8 Joint mobility (Beighton score); CESC cis rs8180040 0.966 rs12636851 chr3:47463567 C/T cg27129171 chr3:47204927 SETD2 0.64 9.81 0.52 1.4e-19 Colorectal cancer; CESC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 10.98 0.56 2.23e-23 Alzheimer's disease; CESC cis rs12541635 0.677 rs2029880 chr8:107024649 T/C cg10147462 chr8:107024639 NA 0.47 7.19 0.4 6.44e-12 Age of smoking initiation; CESC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg05332525 chr7:65337924 VKORC1L1 0.52 6.46 0.37 5e-10 Aortic root size; CESC cis rs12477438 0.798 rs1993230 chr2:99686079 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.87 -0.56 5.17e-23 Chronic sinus infection; CESC cis rs10492096 0.853 rs7300092 chr12:6607364 T/C cg13857086 chr12:6580257 VAMP1 0.53 5.42 0.32 1.33e-7 Hip geometry; CESC cis rs7523050 0.643 rs17621922 chr1:109404454 C/T cg08274380 chr1:109419600 GPSM2 0.85 6.16 0.35 2.74e-9 Fat distribution (HIV); CESC cis rs8141529 0.732 rs2239815 chr22:29192670 C/T cg15103426 chr22:29168792 CCDC117 -0.66 -9.67 -0.51 3.87e-19 Lymphocyte counts; CESC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg25204440 chr1:209979598 IRF6 0.63 8.13 0.45 1.64e-14 Cleft lip with or without cleft palate; CESC cis rs35160687 0.644 rs1863061 chr2:86512907 C/T cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.16 -0.3 4.88e-7 Night sleep phenotypes; CESC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.01 -0.48 4.16e-17 Developmental language disorder (linguistic errors); CESC cis rs7727544 0.684 rs272869 chr5:131677997 A/G cg24060327 chr5:131705240 SLC22A5 -0.61 -8.14 -0.45 1.53e-14 Blood metabolite levels; CESC cis rs854765 0.547 rs2955355 chr17:17948475 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.55 -7.27 -0.41 4.15e-12 Total body bone mineral density; CESC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg02018176 chr4:1364513 KIAA1530 0.62 7.97 0.44 4.61e-14 Longevity; CESC cis rs1594829 0.535 rs1434022 chr8:26153222 G/A cg11498726 chr8:26250323 BNIP3L -0.4 -6.06 -0.35 4.68e-9 Height; CESC cis rs539096 0.500 rs2527776 chr1:44345292 G/A cg13606994 chr1:44402422 ARTN -0.38 -6.0 -0.35 6.48e-9 Intelligence (multi-trait analysis); CESC cis rs2294693 0.530 rs9394761 chr6:41033640 A/C cg14769373 chr6:40998127 UNC5CL -0.42 -5.18 -0.3 4.3e-7 Gastric cancer;Non-cardia gastric cancer; CESC cis rs4478858 0.839 rs10798834 chr1:31708977 G/A cg00250761 chr1:31883323 NA -0.29 -5.71 -0.33 2.95e-8 Alcohol dependence; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26504019 chr21:37528663 NA -0.39 -6.07 -0.35 4.38e-9 Gambling; CESC cis rs2130392 0.962 rs7660116 chr4:185626542 G/A cg21366198 chr4:185655624 MLF1IP -0.42 -5.97 -0.34 7.57e-9 Kawasaki disease; CESC cis rs2243480 1.000 rs4149468 chr7:65825690 T/C cg12463550 chr7:65579703 CRCP 0.71 5.51 0.32 8.58e-8 Diabetic kidney disease; CESC cis rs7208859 0.623 rs55814012 chr17:29077697 T/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3096299 0.591 rs748940 chr16:89440757 T/A cg08392591 chr16:89556376 ANKRD11 0.41 5.15 0.3 5.06e-7 Multiple myeloma (IgH translocation); CESC cis rs79387448 0.701 rs3752659 chr2:103001598 A/G cg09003973 chr2:102972529 NA 0.95 7.62 0.42 4.39e-13 Gut microbiota (bacterial taxa); CESC cis rs9768139 0.935 rs116290351 chr7:158119712 T/A cg25566285 chr7:158114605 PTPRN2 -0.51 -8.63 -0.47 5.71e-16 Calcium levels; CESC cis rs10911232 0.507 rs9787327 chr1:182978459 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 13.29 0.63 3.24e-31 Hypertriglyceridemia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04631728 chr17:4607671 PELP1 -0.69 -8.03 -0.44 3.21e-14 Gut microbiome composition (summer); CESC cis rs1580019 0.844 rs1037322 chr7:32501857 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.89 12.66 0.61 4.86e-29 Cognitive ability; CESC cis rs820218 0.962 rs820131 chr17:73669915 T/C cg01592526 chr17:73663357 RECQL5;SAP30BP 0.45 5.81 0.34 1.78e-8 Rotator cuff tears; CESC cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg17427002 chr7:12443146 VWDE -0.52 -5.04 -0.3 8.67e-7 Coronary artery disease; CESC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg08470875 chr2:26401718 FAM59B 0.75 7.78 0.43 1.63e-13 Gut microbiome composition (summer); CESC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg07507251 chr3:52567010 NT5DC2 0.34 5.91 0.34 1.04e-8 Electroencephalogram traits; CESC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg01570182 chr17:44337453 NA -0.64 -8.5 -0.46 1.35e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7617773 0.694 rs13099560 chr3:48204768 C/T cg11946769 chr3:48343235 NME6 -0.62 -8.53 -0.46 1.16e-15 Coronary artery disease; CESC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.16 0.53 1.09e-20 Prudent dietary pattern; CESC cis rs3008870 0.755 rs3736905 chr1:67392614 A/G cg02640540 chr1:67518911 SLC35D1 0.44 5.35 0.31 1.93e-7 Lymphocyte percentage of white cells; CESC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.74 -10.7 -0.55 1.87e-22 Prudent dietary pattern; CESC cis rs11122272 0.735 rs1416916 chr1:231533027 A/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg22920501 chr2:26401640 FAM59B 0.91 9.92 0.52 6.43e-20 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20349076 chr11:118992192 HINFP 0.56 6.5 0.37 3.9e-10 Gut microbiome composition (summer); CESC cis rs1190552 0.846 rs3783381 chr14:102965435 A/G cg18135206 chr14:102964638 TECPR2 0.42 5.32 0.31 2.22e-7 Blood protein levels; CESC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg04944784 chr2:26401820 FAM59B -0.87 -10.16 -0.53 1.04e-20 Gut microbiome composition (summer); CESC cis rs826838 1.000 rs7953227 chr12:38946193 G/A cg26384229 chr12:38710491 ALG10B 0.82 14.87 0.67 9.2e-37 Heart rate; CESC cis rs2228479 0.867 rs12930056 chr16:89946649 C/A cg14709524 chr16:89940631 TCF25 0.74 5.75 0.33 2.43e-8 Skin colour saturation; CESC cis rs3812762 0.912 rs10769954 chr11:8783713 A/G cg03980550 chr11:8754370 ST5 0.35 5.03 0.3 8.91e-7 Hypospadias; CESC cis rs9527 0.590 rs12355120 chr10:104852166 T/G cg04362960 chr10:104952993 NT5C2 0.45 5.75 0.33 2.5e-8 Arsenic metabolism; CESC cis rs950776 0.518 rs952216 chr15:78819202 C/T cg06917634 chr15:78832804 PSMA4 0.79 12.0 0.59 8.43e-27 Sudden cardiac arrest; CESC cis rs10818894 0.611 rs10117455 chr9:126692599 G/T cg16191174 chr9:126692580 DENND1A 0.62 8.0 0.44 3.99e-14 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); CESC cis rs847577 0.832 rs1799068 chr7:97707069 G/T cg21770322 chr7:97807741 LMTK2 -0.52 -8.02 -0.44 3.49e-14 Breast cancer; CESC cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg20476274 chr7:133979776 SLC35B4 0.65 9.4 0.5 2.76e-18 Mean platelet volume; CESC cis rs6076065 1.000 rs6076065 chr20:23368411 C/A cg12062639 chr20:23401060 NAPB 0.42 5.2 0.3 3.94e-7 Facial morphology (factor 15, philtrum width); CESC cis rs950027 0.596 rs2467853 chr15:45698793 T/G cg21132104 chr15:45694354 SPATA5L1 0.65 8.47 0.46 1.66e-15 Response to fenofibrate (adiponectin levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14551182 chr11:16626476 NA 0.55 6.46 0.37 4.87e-10 Gut microbiome composition (summer); CESC trans rs35110281 0.548 rs7276316 chr21:45029333 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 7.13 0.4 9.65e-12 Mean corpuscular volume; CESC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg04369109 chr6:150039330 LATS1 -0.39 -5.31 -0.31 2.29e-7 Lung cancer; CESC cis rs12545109 0.842 rs2670050 chr8:57402914 T/G cg09654669 chr8:57350985 NA -0.57 -7.23 -0.41 5.09e-12 Obesity-related traits; CESC cis rs10818894 0.515 rs10818831 chr9:126312791 C/T cg16191174 chr9:126692580 DENND1A 0.55 5.99 0.35 6.67e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); CESC cis rs2011503 0.941 rs72999068 chr19:19380685 A/G cg11584989 chr19:19387371 SF4 0.61 7.3 0.41 3.41e-12 Bipolar disorder; CESC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg27121462 chr16:89883253 FANCA 0.82 12.03 0.59 6.84e-27 Vitiligo; CESC cis rs6691722 0.503 rs12086212 chr1:24708740 C/T cg02336364 chr1:24764700 NIPAL3 0.33 6.66 0.38 1.58e-10 Response to interferon beta in multiple sclerosis; CESC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 9.76 0.51 2.07e-19 Platelet count; CESC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg09913183 chr17:42254507 C17orf65;ASB16 -0.66 -8.76 -0.47 2.37e-16 Total body bone mineral density; CESC cis rs8114671 0.647 rs6060267 chr20:33734012 A/G cg24642439 chr20:33292090 TP53INP2 0.51 6.5 0.37 3.86e-10 Height; CESC cis rs206966 0.935 rs11065094 chr12:120806706 C/G cg21001641 chr12:120729728 NA -0.64 -5.14 -0.3 5.37e-7 Breast cancer; CESC trans rs4950322 0.580 rs2014106 chr1:146590081 C/T cg04954894 chr8:38089920 DDHD2 -0.59 -6.39 -0.37 7.54e-10 Protein quantitative trait loci; CESC cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg05347473 chr6:146136440 FBXO30 0.52 6.73 0.38 1.06e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4148883 0.629 rs10009145 chr4:100047929 G/A cg12011299 chr4:100065546 ADH4 0.71 10.62 0.55 3.4e-22 Alcohol dependence; CESC cis rs858239 0.601 rs6980224 chr7:23149137 C/T cg23682824 chr7:23144976 KLHL7 0.55 7.63 0.42 4.25e-13 Cerebrospinal fluid biomarker levels; CESC cis rs7927592 0.763 rs10896351 chr11:68386896 G/A cg20283391 chr11:68216788 NA -0.42 -5.09 -0.3 6.65e-7 Total body bone mineral density; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg25495775 chr17:46970705 ATP5G1 -0.45 -6.28 -0.36 1.35e-9 Asthma; CESC cis rs9488822 0.676 rs868943 chr6:116337503 G/A cg26893134 chr6:116381904 FRK 0.25 6.14 0.35 3.03e-9 Cholesterol, total;LDL cholesterol; CESC cis rs9291683 0.595 rs35501905 chr4:10053431 C/T cg02734326 chr4:10020555 SLC2A9 0.47 6.73 0.38 1.07e-10 Bone mineral density; CESC cis rs7680126 0.596 rs4698009 chr4:10284993 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -5.15 -0.3 4.98e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs12824058 0.831 rs7979497 chr12:130804706 C/T cg24838063 chr12:130822603 PIWIL1 0.61 7.96 0.44 5.22e-14 Menopause (age at onset); CESC cis rs60154123 0.505 rs77990373 chr1:210041111 T/C cg25204440 chr1:209979598 IRF6 0.67 6.11 0.35 3.54e-9 Coronary artery disease; CESC cis rs3960554 0.741 rs10232162 chr7:75702505 C/T cg17325771 chr7:75508891 RHBDD2 -0.36 -5.37 -0.31 1.72e-7 Eotaxin levels; CESC cis rs3767633 0.925 rs6427633 chr1:161849569 C/T cg09175582 chr1:161736000 ATF6 0.86 7.02 0.4 1.91e-11 IgG glycosylation; CESC cis rs2688608 0.618 rs28718766 chr10:75489844 C/A cg23231163 chr10:75533350 FUT11 -0.37 -5.57 -0.32 6.23e-8 Inflammatory bowel disease; CESC cis rs2933343 0.729 rs1683816 chr3:128651195 G/T cg25356066 chr3:128598488 ACAD9 -0.64 -8.84 -0.48 1.32e-16 IgG glycosylation; CESC cis rs9858542 0.953 rs10640 chr3:49454277 G/A cg03060546 chr3:49711283 APEH -0.52 -5.91 -0.34 1.06e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs634534 0.562 rs661335 chr11:65754061 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.74 10.65 0.55 2.7e-22 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs654950 0.901 rs607586 chr1:42004379 C/T cg06885757 chr1:42089581 HIVEP3 -0.68 -10.85 -0.55 6e-23 Airway imaging phenotypes; CESC cis rs116095464 1.000 rs7721278 chr5:310530 G/A cg22857025 chr5:266934 NA -1.17 -10.45 -0.54 1.22e-21 Breast cancer; CESC cis rs362272 0.545 rs2236052 chr4:3318413 C/T cg14583973 chr4:3374767 RGS12 -0.31 -5.57 -0.32 6.4e-8 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27449959 chr8:146024786 ZNF517 -0.56 -6.44 -0.37 5.56e-10 Gut microbiome composition (summer); CESC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg18446336 chr7:2847575 GNA12 -0.4 -6.0 -0.35 6.62e-9 Height; CESC cis rs12586317 0.547 rs112510746 chr14:35491833 T/G cg16230307 chr14:35515116 FAM177A1 0.99 10.61 0.55 3.72e-22 Psoriasis; CESC cis rs2380220 0.541 rs72928283 chr6:96082490 A/C cg23517279 chr6:96025343 MANEA -0.56 -5.46 -0.32 1.1e-7 Behavioural disinhibition (generation interaction); CESC cis rs34638657 0.702 rs62044259 chr16:82199523 A/T cg09439754 chr16:82129088 HSD17B2 -0.37 -6.42 -0.37 6.31e-10 Lung adenocarcinoma; CESC cis rs3762637 1.000 rs72958458 chr3:122185549 T/C cg24169773 chr3:122142474 KPNA1 -0.54 -6.33 -0.36 1.04e-9 LDL cholesterol levels; CESC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg05313129 chr8:58192883 C8orf71 -0.54 -6.23 -0.36 1.82e-9 Developmental language disorder (linguistic errors); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg21939482 chr7:6388130 C7orf70 -0.46 -6.05 -0.35 4.83e-9 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06537257 chr13:41768693 KBTBD7 0.62 6.75 0.38 9.39e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16636271 chr6:139694487 CITED2 0.58 7.07 0.4 1.4e-11 Gut microbiome composition (summer); CESC trans rs79976124 0.879 rs12213669 chr6:66627704 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.74 8.48 0.46 1.58e-15 Type 2 diabetes; CESC cis rs2204008 0.677 rs1581356 chr12:38391467 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.45 0.32 1.14e-7 Bladder cancer; CESC cis rs12995491 0.933 rs13023008 chr2:88530933 G/A cg04511125 chr2:88470314 THNSL2 -0.51 -7.36 -0.41 2.35e-12 Response to metformin (IC50); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11240755 chr1:26147348 FAM54B;LOC646471 0.58 6.3 0.36 1.25e-9 Gut microbiome composition (summer); CESC cis rs4843747 0.671 rs13334603 chr16:88116016 T/C cg06915872 chr16:87998081 BANP 0.43 5.08 0.3 6.99e-7 Menopause (age at onset); CESC cis rs950027 0.549 rs11636114 chr15:45601412 C/G cg21132104 chr15:45694354 SPATA5L1 0.57 6.84 0.39 5.55e-11 Response to fenofibrate (adiponectin levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27502791 chr1:65886279 LEPR;LEPROT 0.62 6.84 0.39 5.59e-11 Gut microbiome composition (summer); CESC cis rs6088590 0.813 rs1884668 chr20:33285514 A/G cg06115741 chr20:33292138 TP53INP2 0.52 6.49 0.37 4.1e-10 Coronary artery disease; CESC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg13777783 chr17:79615861 NA 0.35 5.79 0.34 1.99e-8 Eye color traits; CESC cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.51 8.5 0.46 1.38e-15 Hemoglobin concentration; CESC cis rs10791097 1.000 rs10791097 chr11:130718630 G/T cg12179176 chr11:130786555 SNX19 -0.56 -7.89 -0.44 8.19e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs9811920 0.603 rs2638948 chr3:99501539 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.45 -7.29 -0.41 3.55e-12 Axial length; CESC cis rs7666738 0.822 rs28367231 chr4:98845726 G/T cg17366294 chr4:99064904 C4orf37 0.52 7.12 0.4 1.03e-11 Colonoscopy-negative controls vs population controls; CESC cis rs6060717 0.571 rs6060761 chr20:34612487 T/G cg23207816 chr20:34252616 CPNE1;RBM12 0.5 6.3 0.36 1.26e-9 Hip circumference adjusted for BMI; CESC cis rs7223966 0.921 rs2727300 chr17:61965398 G/A cg25324976 chr17:61989376 CSHL1 0.4 5.59 0.32 5.76e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs7772486 0.720 rs9403757 chr6:146261271 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -13.3 -0.63 2.94e-31 Lobe attachment (rater-scored or self-reported); CESC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg16325326 chr1:53192061 ZYG11B -0.7 -11.18 -0.57 4.87e-24 Monocyte count; CESC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg20243544 chr17:37824526 PNMT -0.48 -6.11 -0.35 3.52e-9 Glomerular filtration rate (creatinine); CESC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg09365446 chr1:150670422 GOLPH3L 0.39 5.23 0.31 3.44e-7 Melanoma; CESC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg27286337 chr10:134555280 INPP5A 0.61 6.95 0.39 2.81e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg04317338 chr11:64019027 PLCB3 0.84 8.42 0.46 2.35e-15 Mean platelet volume; CESC cis rs6570726 0.905 rs377143 chr6:145834220 C/T cg23711669 chr6:146136114 FBXO30 0.74 10.77 0.55 1.1e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs2625529 0.938 rs4777464 chr15:72131763 C/T cg16672083 chr15:72433130 SENP8 -0.41 -5.8 -0.34 1.87e-8 Red blood cell count; CESC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg16325326 chr1:53192061 ZYG11B -0.85 -14.8 -0.67 1.59e-36 Monocyte count; CESC cis rs13631 0.928 rs9411308 chr9:140000115 C/T cg14289826 chr9:140003911 NA 0.34 6.27 0.36 1.42e-9 Cerebrospinal fluid biomarker levels; CESC cis rs4288356 1 rs4288356 chr8:141055724 G/A cg06693505 chr8:141057453 TRAPPC9 -0.37 -5.98 -0.34 7.19e-9 Pulse pressure; CESC cis rs950169 1.000 rs1818950 chr15:84722521 A/G cg17507749 chr15:85114479 UBE2QP1 0.63 6.98 0.39 2.31e-11 Schizophrenia; CESC cis rs7255436 0.830 rs4350678 chr19:8447366 A/G cg10174797 chr19:8464628 RAB11B 0.4 5.67 0.33 3.75e-8 HDL cholesterol; CESC cis rs2479724 0.901 rs6458244 chr6:41790455 C/T cg17623882 chr6:41773611 USP49 0.39 5.69 0.33 3.43e-8 Menarche (age at onset); CESC cis rs400736 0.930 rs225100 chr1:8066914 C/T cg25007680 chr1:8021821 PARK7 -0.72 -10.27 -0.53 4.92e-21 Response to antidepressants and depression; CESC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 12.72 0.62 2.99e-29 Alzheimer's disease; CESC cis rs1801251 1.000 rs2675971 chr2:233726154 A/G cg08000102 chr2:233561755 GIGYF2 -0.71 -10.04 -0.53 2.53e-20 Coronary artery disease; CESC cis rs4589502 1.000 rs16950284 chr15:67154184 A/G cg12317470 chr15:67143691 NA -0.67 -6.03 -0.35 5.42e-9 Lung cancer (smoking interaction); CESC cis rs61776719 0.520 rs11485595 chr1:38411350 C/T cg17077180 chr1:38461687 NA 0.45 6.88 0.39 4.33e-11 Coronary artery disease; CESC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg09177884 chr7:1199841 ZFAND2A -0.56 -6.97 -0.39 2.55e-11 Longevity;Endometriosis; CESC cis rs938554 0.784 rs11722229 chr4:9980697 C/A cg00071950 chr4:10020882 SLC2A9 0.48 5.76 0.33 2.36e-8 Blood metabolite levels; CESC cis rs3126085 0.935 rs11204976 chr1:152273777 C/T cg03465714 chr1:152285911 FLG 0.51 5.87 0.34 1.32e-8 Atopic dermatitis; CESC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg26039829 chr8:22132926 PIWIL2 0.39 6.05 0.35 4.84e-9 Hypertriglyceridemia; CESC cis rs12822507 0.868 rs61915599 chr12:12768409 A/G cg11838227 chr12:12764436 CREBL2 -0.41 -5.23 -0.31 3.39e-7 Systemic lupus erythematosus; CESC cis rs7584330 0.554 rs6760890 chr2:238400645 G/A cg14458575 chr2:238380390 NA 0.7 6.12 0.35 3.35e-9 Prostate cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15309264 chr2:58274034 VRK2 0.46 6.08 0.35 4.07e-9 Systemic lupus erythematosus; CESC cis rs7772486 0.790 rs2254288 chr6:146204470 G/A cg05347473 chr6:146136440 FBXO30 0.53 7.05 0.4 1.59e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.964 rs72827413 chr17:17988299 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.43 -5.71 -0.33 2.97e-8 Total body bone mineral density; CESC cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.59 -7.04 -0.4 1.65e-11 Multiple sclerosis; CESC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Urate levels; CESC cis rs754466 0.606 rs12356375 chr10:79594514 C/A cg17075019 chr10:79541650 NA -0.88 -13.94 -0.65 1.66e-33 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3768617 0.510 rs3765522 chr1:183077618 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 14.11 0.65 4.24e-34 Fuchs's corneal dystrophy; CESC cis rs11608355 0.545 rs12822891 chr12:109896002 A/G cg05360138 chr12:110035743 NA 0.82 8.92 0.48 7.93e-17 Neuroticism; CESC cis rs617791 0.530 rs735942 chr11:65749337 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.45 -5.1 -0.3 6.46e-7 Breast cancer; CESC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg24060327 chr5:131705240 SLC22A5 -0.42 -5.26 -0.31 3e-7 Lung function (FEV1/FVC); CESC trans rs116095464 0.558 rs13354585 chr5:242263 G/C cg00938859 chr5:1591904 SDHAP3 0.64 7.01 0.4 2.01e-11 Breast cancer; CESC cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg20090143 chr19:45452003 APOC2 0.37 6.39 0.37 7.54e-10 Blood protein levels; CESC cis rs501120 1.000 rs604674 chr10:44756894 G/T cg09554077 chr10:44749378 NA 0.52 6.91 0.39 3.59e-11 Coronary artery disease;Coronary heart disease; CESC cis rs4595586 0.545 rs1319791 chr12:39372486 G/T cg13010199 chr12:38710504 ALG10B 0.44 5.51 0.32 8.37e-8 Morning vs. evening chronotype; CESC cis rs4642101 0.662 rs9840766 chr3:12821870 G/A cg05775895 chr3:12838266 CAND2 0.37 5.45 0.32 1.17e-7 QRS complex (12-leadsum); CESC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 9.98 0.52 4.1e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg05215272 chr17:6899095 ALOX12 -0.44 -8.33 -0.46 4.45e-15 Tonsillectomy; CESC cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.15 0.3 5.05e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6831352 0.918 rs17817958 chr4:100061245 A/C cg13256891 chr4:100009986 ADH5 0.75 7.82 0.43 1.24e-13 Alcohol dependence; CESC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.23 0.36 1.87e-9 Menopause (age at onset); CESC cis rs4566357 0.615 rs12621808 chr2:227909522 A/C cg11843606 chr2:227700838 RHBDD1 -0.46 -6.3 -0.36 1.26e-9 Coronary artery disease; CESC cis rs6570726 0.935 rs428659 chr6:145827039 T/C cg23711669 chr6:146136114 FBXO30 0.8 12.02 0.59 7.3e-27 Lobe attachment (rater-scored or self-reported); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08273200 chr1:39338480 MYCBP -0.45 -6.41 -0.37 6.71e-10 Gambling; CESC cis rs6976053 0.541 rs314359 chr7:100411278 T/C cg20848291 chr7:100343083 ZAN 0.4 5.5 0.32 9.14e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CESC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg10578991 chr7:12443926 VWDE -0.51 -5.67 -0.33 3.75e-8 Coronary artery disease; CESC cis rs8070740 0.898 rs11078562 chr17:5326857 A/T cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.42 0.37 6.41e-10 Menopause (age at onset); CESC cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -6.54 -0.37 3.16e-10 Hemoglobin concentration; CESC cis rs2243480 1.000 rs431076 chr7:65600320 A/C cg13147721 chr7:65941812 NA -0.98 -9.24 -0.49 8.33e-18 Diabetic kidney disease; CESC cis rs7100689 0.646 rs7089003 chr10:82124155 T/C cg00277334 chr10:82204260 NA -0.58 -7.76 -0.43 1.84e-13 Post bronchodilator FEV1; CESC cis rs3093024 1.000 rs3093023 chr6:167534290 A/G cg07741184 chr6:167504864 NA -0.33 -5.58 -0.32 5.88e-8 Rheumatoid arthritis; CESC cis rs117623576 0.680 rs16932874 chr10:32358438 T/C cg03047570 chr10:32398778 NA -0.58 -6.24 -0.36 1.77e-9 Anti-saccade response; CESC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 5.13 0.3 5.68e-7 Bipolar disorder; CESC cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs7561273 0.586 rs12477718 chr2:24330539 A/G cg06627628 chr2:24431161 ITSN2 -0.46 -5.42 -0.32 1.34e-7 Quantitative traits; CESC cis rs4076764 0.801 rs12046142 chr1:163375247 G/A cg06092702 chr1:163392909 NA -0.39 -5.58 -0.32 6.08e-8 Motion sickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12145289 chr11:65385911 PCNXL3 -0.54 -6.75 -0.38 9.56e-11 Gut microbiome composition (summer); CESC cis rs7524258 0.903 rs763197 chr1:7289959 A/G cg07173049 chr1:7289937 CAMTA1 0.48 7.23 0.41 5.08e-12 Tourette's syndrome or obsessive-compulsive disorder; CESC cis rs6500395 1.000 rs12598514 chr16:48689319 T/C cg04672837 chr16:48644449 N4BP1 -0.51 -6.37 -0.36 8.27e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4711336 0.967 rs4713658 chr6:33667117 C/G cg14003231 chr6:33640908 ITPR3 0.3 5.31 0.31 2.32e-7 Height; CESC cis rs5758511 0.514 rs5758580 chr22:42493875 T/C cg00645731 chr22:42541494 CYP2D7P1 0.63 9.78 0.52 1.69e-19 Birth weight; CESC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg07507251 chr3:52567010 NT5DC2 0.42 7.33 0.41 2.77e-12 Bipolar disorder; CESC cis rs7219021 0.926 rs7208848 chr17:46855295 C/T cg16584676 chr17:46985605 UBE2Z -0.56 -6.32 -0.36 1.08e-9 Schizophrenia or bipolar disorder; CESC cis rs694739 0.964 rs2510066 chr11:64052447 C/T cg02228329 chr11:64053129 BAD;GPR137 0.67 8.6 0.47 6.86e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CESC cis rs4780401 0.609 rs8063099 chr16:11806714 T/G cg01061890 chr16:11836724 TXNDC11 -0.56 -7.59 -0.42 5.59e-13 Rheumatoid arthritis; CESC cis rs57221529 0.600 rs11750269 chr5:666270 G/A cg09021430 chr5:549028 NA -0.43 -5.12 -0.3 5.86e-7 Lung disease severity in cystic fibrosis; CESC cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 6.68 0.38 1.44e-10 Eosinophil percentage of white cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18494018 chr7:148581708 EZH2 0.5 6.05 0.35 4.93e-9 Gut microbiome composition (summer); CESC cis rs561341 1.000 rs498391 chr17:30328704 G/A cg00745463 chr17:30367425 LRRC37B -0.79 -7.41 -0.41 1.68e-12 Hip circumference adjusted for BMI; CESC trans rs10411161 0.702 rs79180893 chr19:52395615 A/G cg22319618 chr22:45562946 NUP50 -0.74 -7.44 -0.42 1.37e-12 Breast cancer; CESC cis rs3740713 1.000 rs73440606 chr11:18464120 C/T cg23797887 chr11:18477753 LDHAL6A -0.54 -5.28 -0.31 2.63e-7 Amyotrophic lateral sclerosis (sporadic); CESC cis rs853679 0.882 rs4713140 chr6:28097193 C/T cg25108566 chr6:27775657 HIST1H2AI;HIST1H2BL 0.77 7.2 0.4 6.37e-12 Depression; CESC cis rs2559856 1.000 rs2559855 chr12:102090080 A/G cg24337881 chr12:102091387 CHPT1 -0.41 -5.6 -0.33 5.34e-8 Blood protein levels; CESC cis rs17826219 0.636 rs7221463 chr17:29080551 A/C cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Body mass index; CESC cis rs6537837 0.668 rs12044778 chr1:110084408 C/T cg05049280 chr1:110155535 GNAT2 0.37 5.18 0.3 4.36e-7 Major depressive disorder; CESC cis rs896854 0.517 rs1011795 chr8:95951073 G/A cg13393036 chr8:95962371 TP53INP1 -0.46 -8.23 -0.45 8.45e-15 Type 2 diabetes; CESC cis rs4835473 0.932 rs4490412 chr4:144908566 C/G cg25736465 chr4:144833511 NA 0.38 5.81 0.34 1.83e-8 Immature fraction of reticulocytes; CESC cis rs11608355 0.515 rs2287184 chr12:109970251 T/C cg05360138 chr12:110035743 NA 0.82 8.91 0.48 8.24e-17 Neuroticism; CESC cis rs12541635 0.966 rs7839195 chr8:107020193 G/A cg10147462 chr8:107024639 NA 0.4 5.81 0.34 1.8e-8 Age of smoking initiation; CESC cis rs6486730 1.000 rs6486730 chr12:129275027 C/T cg09035930 chr12:129282057 SLC15A4 0.45 6.22 0.36 1.97e-9 Systemic lupus erythematosus; CESC cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg18180107 chr4:99064573 C4orf37 0.4 5.14 0.3 5.32e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7179456 0.515 rs602602 chr15:59057023 T/A cg05156742 chr15:59063176 FAM63B 0.51 5.9 0.34 1.12e-8 Asperger disorder; CESC cis rs10883723 0.810 rs7092622 chr10:104249919 T/G cg22532475 chr10:104410764 TRIM8 -0.33 -5.67 -0.33 3.67e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg06074448 chr4:187884817 NA -0.47 -7.35 -0.41 2.52e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs3820068 0.603 rs72647138 chr1:15980929 C/T cg18133145 chr1:16060689 PLEKHM2 -0.4 -5.15 -0.3 5.15e-7 Systolic blood pressure; CESC trans rs853679 0.546 rs35744819 chr6:28318331 G/T cg06606381 chr12:133084897 FBRSL1 -1.11 -8.41 -0.46 2.54e-15 Depression; CESC trans rs1814175 0.791 rs10219223 chr11:49791468 A/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.87 -0.77 1.97e-54 Height; CESC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg24675658 chr1:53192096 ZYG11B 0.68 8.67 0.47 4.34e-16 Monocyte count; CESC cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.82 -12.11 -0.6 3.74e-27 Systemic lupus erythematosus; CESC cis rs2228479 0.850 rs3785279 chr16:89824562 G/C cg00800038 chr16:89945340 TCF25 -0.92 -7.67 -0.43 3.37e-13 Skin colour saturation; CESC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg00149659 chr3:10157352 C3orf10 0.7 8.38 0.46 3.2e-15 Alzheimer's disease; CESC cis rs9443189 0.570 rs276687 chr6:76429995 G/T cg01950844 chr6:76311363 SENP6 -0.84 -8.07 -0.44 2.4e-14 Prostate cancer; CESC cis rs9291683 0.530 rs998675 chr4:9948829 A/G cg02734326 chr4:10020555 SLC2A9 0.43 6.48 0.37 4.49e-10 Bone mineral density; CESC cis rs13385 0.769 rs11538394 chr5:139574050 G/A cg26211634 chr5:139558579 C5orf32 0.47 5.28 0.31 2.75e-7 Atrial fibrillation; CESC cis rs6460942 0.591 rs7804805 chr7:12332066 C/G cg20607287 chr7:12443886 VWDE -0.63 -6.83 -0.39 5.83e-11 Coronary artery disease; CESC cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg05340658 chr4:99064831 C4orf37 0.56 7.36 0.41 2.29e-12 Colonoscopy-negative controls vs population controls; CESC cis rs7259376 0.936 rs12983542 chr19:22590585 C/G cg02657401 chr19:22469223 NA 0.26 5.12 0.3 5.76e-7 Menopause (age at onset); CESC cis rs9527 0.544 rs1572578 chr10:104822431 C/G cg04362960 chr10:104952993 NT5C2 0.45 5.76 0.33 2.34e-8 Arsenic metabolism; CESC cis rs7124681 0.584 rs4752792 chr11:47815702 G/A cg18512352 chr11:47633146 NA -0.36 -5.55 -0.32 6.84e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg04944784 chr2:26401820 FAM59B 0.96 10.55 0.54 5.79e-22 Gut microbiome composition (summer); CESC cis rs2637266 0.935 rs2583050 chr10:78403615 C/T cg18941641 chr10:78392320 NA 0.44 8.58 0.47 7.88e-16 Pulmonary function; CESC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg05564831 chr3:52568323 NT5DC2 0.46 7.19 0.4 6.64e-12 Bipolar disorder; CESC cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg20307385 chr11:47447363 PSMC3 -0.5 -6.09 -0.35 4.06e-9 Subjective well-being; CESC cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.48 6.42 0.37 6.36e-10 Personality dimensions; CESC cis rs1843834 0.539 rs1494109 chr2:225441833 G/A cg22509189 chr2:225307070 NA -0.42 -5.63 -0.33 4.6e-8 IgE levels in asthmatics (D.p. specific); CESC cis rs6088590 0.561 rs6059932 chr20:33175466 C/T cg24642439 chr20:33292090 TP53INP2 0.63 8.39 0.46 2.84e-15 Coronary artery disease; CESC cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg05340658 chr4:99064831 C4orf37 0.83 12.88 0.62 8.59e-30 Colonoscopy-negative controls vs population controls; CESC cis rs9796 0.558 rs6492993 chr15:41526104 G/A cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.43 -0.37 5.78e-10 Menopause (age at onset); CESC cis rs644799 0.932 rs572015 chr11:95637416 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.61 7.99 0.44 4.2e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.49 -6.12 -0.35 3.41e-9 Tonsillectomy; CESC cis rs9487051 0.803 rs11153161 chr6:109541774 A/G cg01475377 chr6:109611718 NA -0.37 -5.34 -0.31 2.01e-7 Reticulocyte fraction of red cells; CESC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg24110177 chr3:50126178 RBM5 0.55 7.47 0.42 1.18e-12 Body mass index; CESC cis rs10489525 0.550 rs6659415 chr1:115632211 C/T cg01522456 chr1:115632236 TSPAN2 0.72 8.88 0.48 1.03e-16 Autism; CESC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg05564831 chr3:52568323 NT5DC2 0.46 6.94 0.39 3.07e-11 Bipolar disorder; CESC cis rs1865760 0.532 rs9295687 chr6:26082710 T/C cg16482183 chr6:26056742 HIST1H1C 0.38 5.11 0.3 6.19e-7 Height; CESC cis rs17826219 0.706 rs8075357 chr17:29057197 A/C cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Body mass index; CESC cis rs67311347 1.000 rs9841335 chr3:40475858 G/A cg09455208 chr3:40491958 NA 0.44 7.53 0.42 8.04e-13 Renal cell carcinoma; CESC trans rs9911652 1.000 rs16957821 chr17:8948104 C/G cg18132964 chr6:155541562 TIAM2 0.53 6.12 0.35 3.39e-9 Cleft lip with or without cleft palate; CESC cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.76 9.88 0.52 8.23e-20 Age-related macular degeneration (geographic atrophy); CESC cis rs3008870 0.755 rs11208974 chr1:67398119 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.63 8.38 0.46 3.04e-15 Lymphocyte percentage of white cells; CESC cis rs16854884 0.632 rs10513234 chr3:143670957 A/G cg06585982 chr3:143692056 C3orf58 -0.53 -6.92 -0.39 3.36e-11 Economic and political preferences (feminism/equality); CESC cis rs17533156 0.612 rs62078287 chr17:75128493 C/T cg18815765 chr17:75136729 SEC14L1 0.5 5.25 0.31 3.16e-7 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs12079745 0.793 rs11806445 chr1:169219029 C/T cg09363564 chr1:169337483 NME7;BLZF1 -1.01 -6.28 -0.36 1.36e-9 QT interval; CESC cis rs225245 0.817 rs2301730 chr17:33998683 A/G cg05299278 chr17:33885742 SLFN14 0.35 5.07 0.3 7.61e-7 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CESC cis rs6542838 0.554 rs4311103 chr2:99538362 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.52 -6.63 -0.38 1.87e-10 Fear of minor pain; CESC cis rs3820928 0.874 rs12105952 chr2:227864521 G/A cg05526886 chr2:227700861 RHBDD1 -0.41 -5.14 -0.3 5.4e-7 Pulmonary function; CESC cis rs2243480 1.000 rs316334 chr7:65602126 G/T cg12463550 chr7:65579703 CRCP 0.74 5.75 0.33 2.4e-8 Diabetic kidney disease; CESC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg22800045 chr5:56110881 MAP3K1 0.5 5.99 0.35 6.65e-9 Coronary artery disease; CESC cis rs59918340 0.728 rs2304279 chr8:142229891 A/G cg16341495 chr8:142228727 SLC45A4 -0.42 -5.11 -0.3 6.15e-7 Immature fraction of reticulocytes; CESC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg23758822 chr17:41437982 NA 1.01 15.21 0.68 5.44e-38 Menopause (age at onset); CESC cis rs2228479 0.850 rs2190808 chr16:89840856 C/T cg04013166 chr16:89971882 TCF25 0.78 6.69 0.38 1.3e-10 Skin colour saturation; CESC cis rs6987853 0.787 rs2923413 chr8:42455308 A/G cg09913449 chr8:42400586 C8orf40 0.42 7.02 0.4 1.88e-11 Mean corpuscular hemoglobin concentration; CESC cis rs7264396 0.563 rs6060570 chr20:34291166 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.78 -0.55 1.03e-22 Total cholesterol levels; CESC cis rs11655198 1 rs11655198 chr17:38026169 C/T cg19468946 chr17:37922297 IKZF3 -0.43 -5.85 -0.34 1.48e-8 Asthma; CESC cis rs1348850 0.831 rs7606235 chr2:178401288 T/C cg22681709 chr2:178499509 PDE11A -0.44 -6.22 -0.36 1.89e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16311803 chr12:88178298 NA -0.6 -6.83 -0.39 5.63e-11 Gut microbiome composition (summer); CESC cis rs6088580 0.609 rs6059844 chr20:33036482 A/G cg08999081 chr20:33150536 PIGU 0.65 11.56 0.58 2.68e-25 Glomerular filtration rate (creatinine); CESC cis rs7216064 1.000 rs58551145 chr17:65837235 A/G cg12091567 chr17:66097778 LOC651250 -0.85 -8.61 -0.47 6.51e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs589448 0.900 rs588493 chr12:69751986 G/A cg20891283 chr12:69753455 YEATS4 0.99 17.16 0.73 6.54e-45 Cerebrospinal fluid biomarker levels; CESC cis rs864537 0.646 rs1723018 chr1:167433420 A/G cg09179987 chr1:167433047 CD247 0.5 7.94 0.44 5.78e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CESC cis rs727505 0.908 rs56155943 chr7:124606346 T/G cg23710748 chr7:124431027 NA -0.46 -7.28 -0.41 3.87e-12 Lewy body disease; CESC cis rs2273669 0.667 rs12216104 chr6:109317635 C/T cg05315195 chr6:109294784 ARMC2 -0.66 -6.28 -0.36 1.36e-9 Prostate cancer; CESC cis rs62005083 0.737 rs56171007 chr14:74502001 A/G cg05179529 chr14:74551516 LIN52;ALDH6A1 0.7 5.22 0.31 3.68e-7 Mean corpuscular volume; CESC cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg25554036 chr4:6271136 WFS1 0.51 8.05 0.44 2.87e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg16743903 chr16:89593216 SPG7 -0.42 -5.42 -0.32 1.31e-7 Multiple myeloma (IgH translocation); CESC cis rs926938 0.618 rs516985 chr1:115495011 G/A cg12756093 chr1:115239321 AMPD1 0.53 7.59 0.42 5.32e-13 Autism; CESC cis rs733592 0.599 rs12819124 chr12:48409054 G/T cg24011408 chr12:48396354 COL2A1 0.44 6.72 0.38 1.09e-10 Plateletcrit; CESC cis rs16973500 0.808 rs72801797 chr16:71975300 A/G cg09427745 chr16:71932006 KIAA0174 -0.49 -5.12 -0.3 5.86e-7 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs9486715 0.867 rs4598081 chr6:96975227 A/G cg18709589 chr6:96969512 KIAA0776 0.47 6.55 0.37 2.95e-10 Headache; CESC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg24101359 chr6:42928495 GNMT 0.6 8.91 0.48 8.14e-17 Alzheimer's disease in APOE e4+ carriers; CESC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.65 7.48 0.42 1.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs72627123 0.500 rs67852564 chr14:74559920 A/G cg05179529 chr14:74551516 LIN52;ALDH6A1 0.53 5.78 0.33 2.07e-8 Morning vs. evening chronotype; CESC cis rs651907 0.557 rs11720745 chr3:101441690 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.44 5.64 0.33 4.29e-8 Colorectal cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg09656405 chr15:69745057 RPLP1 0.51 6.56 0.37 2.85e-10 Gut microbiota (bacterial taxa); CESC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg19774624 chr17:42201019 HDAC5 -0.88 -14.32 -0.66 7.95e-35 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09292873 chr10:111683347 XPNPEP1 0.5 6.24 0.36 1.71e-9 Gut microbiome composition (summer); CESC cis rs2073300 0.609 rs6132610 chr20:23403987 C/T cg12062639 chr20:23401060 NAPB 1.06 8.23 0.45 8.54e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.6 8.47 0.46 1.69e-15 Bipolar disorder; CESC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs5769707 0.837 rs5769709 chr22:50021757 C/T cg05373962 chr22:49881684 NA -0.37 -6.11 -0.35 3.55e-9 Monocyte count;Monocyte percentage of white cells; CESC cis rs10089 1.000 rs4836360 chr5:127458161 T/C cg19767477 chr5:127420684 SLC12A2 -0.41 -5.5 -0.32 8.94e-8 Ileal carcinoids; CESC cis rs27434 0.539 rs40604 chr5:96155900 G/A cg16492584 chr5:96139282 ERAP1 -0.36 -5.09 -0.3 6.81e-7 Ankylosing spondylitis; CESC cis rs6570726 0.846 rs6899900 chr6:145883873 T/G cg05347473 chr6:146136440 FBXO30 0.49 6.43 0.37 6.06e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg23018236 chr17:30244563 NA -0.52 -5.1 -0.3 6.39e-7 Hip circumference adjusted for BMI; CESC cis rs9837602 1.000 rs9833980 chr3:99767096 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 7.56 0.42 6.43e-13 Breast cancer; CESC cis rs798554 0.704 rs798512 chr7:2782592 C/G cg09658497 chr7:2847517 GNA12 -0.35 -5.26 -0.31 2.92e-7 Height; CESC cis rs868036 0.609 rs3784707 chr15:68043878 A/C cg24579218 chr15:68104479 NA -0.37 -5.11 -0.3 6.12e-7 Restless legs syndrome; CESC cis rs2197308 0.740 rs10880619 chr12:37922720 T/C cg26384229 chr12:38710491 ALG10B 0.75 11.12 0.56 8.21e-24 Morning vs. evening chronotype; CESC cis rs34779708 0.966 rs12769575 chr10:35435927 A/T cg03585969 chr10:35415529 CREM 0.76 10.0 0.52 3.56e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6088580 0.609 rs945674 chr20:32964247 G/C cg08999081 chr20:33150536 PIGU -0.65 -11.29 -0.57 2.22e-24 Glomerular filtration rate (creatinine); CESC cis rs7264396 0.790 rs8125090 chr20:34360015 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -11.82 -0.59 3.57e-26 Total cholesterol levels; CESC cis rs11098499 0.874 rs10022508 chr4:120115228 A/G cg09307838 chr4:120376055 NA 0.74 9.24 0.49 8.6e-18 Corneal astigmatism; CESC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg04369109 chr6:150039330 LATS1 -0.38 -5.26 -0.31 3.04e-7 Lung cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg23216004 chr7:23624964 CLK2P 0.38 6.06 0.35 4.73e-9 Fibrinogen levels; CESC cis rs240764 0.764 rs12208241 chr6:100933472 T/C cg21058520 chr6:100914733 NA 0.39 6.05 0.35 5.04e-9 Neuroticism; CESC cis rs4642101 0.824 rs9825233 chr3:12843368 A/G cg05775895 chr3:12838266 CAND2 -0.37 -5.67 -0.33 3.66e-8 QRS complex (12-leadsum); CESC cis rs10899021 0.920 rs7112664 chr11:74348426 T/C cg25880958 chr11:74394337 NA -0.75 -7.78 -0.43 1.6e-13 Response to metformin (IC50); CESC cis rs9916302 0.904 rs7501488 chr17:37576417 T/G cg00129232 chr17:37814104 STARD3 -0.58 -7.67 -0.43 3.25e-13 Glomerular filtration rate (creatinine); CESC cis rs367943 0.698 rs6594746 chr5:112995895 A/C cg12552261 chr5:112820674 MCC -0.48 -6.2 -0.36 2.1e-9 Type 2 diabetes; CESC cis rs7208859 0.673 rs11658435 chr17:29228561 A/G cg19761014 chr17:28927070 LRRC37B2 0.73 5.77 0.33 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1784581 0.588 rs9295179 chr6:162420546 G/A cg17173639 chr6:162384350 PARK2 0.58 8.89 0.48 9.89e-17 Itch intensity from mosquito bite; CESC cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg03213289 chr20:61660250 NA 0.39 6.07 0.35 4.42e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg06221963 chr1:154839813 KCNN3 -0.66 -11.17 -0.57 5.33e-24 Prostate cancer; CESC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg11890956 chr21:40555474 PSMG1 0.96 15.92 0.7 1.67e-40 Cognitive function; CESC cis rs6667605 0.506 rs10797440 chr1:2541269 A/G cg20673091 chr1:2541236 MMEL1 0.45 7.79 0.43 1.5e-13 Inflammatory bowel disease;Ulcerative colitis; CESC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg26338869 chr17:61819248 STRADA 0.67 8.82 0.48 1.6e-16 Prudent dietary pattern; CESC cis rs10883723 0.668 rs12414407 chr10:104387019 A/G ch.10.2196322F chr10:104248062 ACTR1A -0.42 -5.18 -0.3 4.35e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs1728785 0.901 rs11865339 chr16:68565296 C/T cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs16854884 0.632 rs4535221 chr3:143658607 A/G cg06585982 chr3:143692056 C3orf58 0.51 6.44 0.37 5.55e-10 Economic and political preferences (feminism/equality); CESC cis rs9287719 0.967 rs4668691 chr2:10740494 C/T cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs9790314 0.502 rs2404342 chr3:161092562 C/T cg03342759 chr3:160939853 NMD3 -0.54 -7.64 -0.42 4.04e-13 Morning vs. evening chronotype; CESC trans rs10435719 0.902 rs11250179 chr8:11800332 C/T cg15556689 chr8:8085844 FLJ10661 0.53 6.55 0.37 3.03e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CESC trans rs7618501 0.602 rs2240327 chr3:50113034 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.43 6.13 0.35 3.11e-9 Intelligence (multi-trait analysis); CESC trans rs1460163 0.685 rs1460162 chr8:80227400 A/C cg23373626 chr5:141031295 FCHSD1 -0.58 -6.21 -0.36 2.07e-9 Creutzfeldt-Jakob disease; CESC cis rs6912958 0.754 rs1051131 chr6:88221546 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.51 -6.83 -0.39 5.94e-11 Monocyte percentage of white cells; CESC cis rs654950 0.806 rs1535505 chr1:42026152 A/G cg06885757 chr1:42089581 HIVEP3 0.51 7.73 0.43 2.24e-13 Airway imaging phenotypes; CESC cis rs6540556 0.723 rs12116437 chr1:209897027 G/A cg05527609 chr1:210001259 C1orf107 -0.66 -7.32 -0.41 2.95e-12 Red blood cell count; CESC cis rs2080501 0.571 rs1861657 chr16:49675807 G/T cg27618369 chr16:49636483 ZNF423 0.36 5.36 0.31 1.84e-7 IgG glycosylation; CESC trans rs10411161 0.702 rs11878580 chr19:52388485 C/T cg22319618 chr22:45562946 NUP50 -0.75 -7.58 -0.42 5.85e-13 Breast cancer; CESC cis rs929354 0.713 rs3802129 chr7:156965297 G/A cg05182265 chr7:156933206 UBE3C -0.5 -7.3 -0.41 3.28e-12 Body mass index; CESC cis rs7000551 0.663 rs11778831 chr8:22335088 C/T cg12081754 chr8:22256438 SLC39A14 0.44 6.11 0.35 3.51e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg12386194 chr3:101231763 SENP7 0.42 5.19 0.3 4.17e-7 Colorectal cancer; CESC cis rs7828089 0.582 rs13282084 chr8:22266280 T/C cg12081754 chr8:22256438 SLC39A14 0.64 9.0 0.48 4.4e-17 Verbal declarative memory; CESC cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg11812906 chr14:75593930 NEK9 0.91 15.5 0.69 5.4e-39 Height; CESC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.37e-9 Developmental language disorder (linguistic errors); CESC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg24642844 chr7:1081250 C7orf50 -0.77 -9.3 -0.5 5.54e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9611565 0.592 rs4481089 chr22:41980892 T/C cg03806693 chr22:41940476 POLR3H -0.87 -10.5 -0.54 8.63e-22 Vitiligo; CESC cis rs12220238 1.000 rs7083534 chr10:75955672 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.59 5.35 0.31 1.86e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg00802000 chr16:706648 WDR90 -0.4 -6.09 -0.35 3.85e-9 Height; CESC cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg12641515 chr19:46296257 DMWD -0.52 -5.71 -0.33 3.07e-8 Coronary artery disease; CESC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.62 -0.33 4.89e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2070488 0.775 rs7374458 chr3:38531211 T/G cg24069376 chr3:38537580 EXOG 0.36 6.14 0.35 3.02e-9 Electrocardiographic conduction measures; CESC cis rs12136530 0.774 rs12563442 chr1:19786695 T/C cg01832549 chr1:19774989 CAPZB -0.44 -6.04 -0.35 5.3e-9 Lead levels in blood; CESC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.44 0.32 1.24e-7 Bipolar disorder; CESC cis rs2932538 0.885 rs6691025 chr1:113177070 G/T cg22162597 chr1:113214053 CAPZA1 -0.58 -7.35 -0.41 2.46e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CESC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg07507251 chr3:52567010 NT5DC2 0.32 5.48 0.32 1.01e-7 Bipolar disorder; CESC cis rs72627509 0.857 rs781658 chr4:57779567 G/A cg26694713 chr4:57773883 REST 0.58 5.68 0.33 3.49e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC trans rs78049276 0.512 rs6855875 chr4:148402737 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.68 -8.83 -0.48 1.47e-16 Pulse pressure; CESC cis rs17826219 0.568 rs59858012 chr17:29078582 C/T cg14008862 chr17:28927542 LRRC37B2 0.74 5.33 0.31 2.1e-7 Body mass index; CESC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg18402987 chr7:1209562 NA 0.76 7.56 0.42 6.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs8018808 0.902 rs147316 chr14:77888664 C/T cg20045696 chr14:77926864 AHSA1 0.42 5.79 0.34 2e-8 Myeloid white cell count; CESC cis rs16866061 1.000 rs2047134 chr2:225347713 A/C cg12698349 chr2:225449008 CUL3 0.71 10.22 0.53 6.8e-21 Acute graft versus host disease in bone marrow transplantation (recipient effect); CESC cis rs10206020 0.921 rs72776302 chr2:1571383 G/A cg26248373 chr2:1572462 NA -0.6 -6.98 -0.39 2.43e-11 IgG glycosylation; CESC cis rs11792861 0.591 rs10979613 chr9:111687584 A/G cg05043794 chr9:111880884 C9orf5 -0.29 -5.35 -0.31 1.92e-7 Menarche (age at onset); CESC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.92 13.57 0.64 3.24e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg05754148 chr16:3507555 NAT15 0.69 7.6 0.42 5.28e-13 Tuberculosis; CESC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg18032046 chr6:28092343 ZSCAN16 -0.6 -6.84 -0.39 5.51e-11 Depression; CESC cis rs9457247 0.765 rs9457256 chr6:167436461 T/C cg23791538 chr6:167370224 RNASET2 -0.55 -7.51 -0.42 8.97e-13 Crohn's disease; CESC cis rs193541 0.632 rs415417 chr5:122322884 G/A cg19412675 chr5:122181750 SNX24 -0.46 -5.39 -0.31 1.58e-7 Glucose homeostasis traits; CESC cis rs7395581 0.959 rs7120118 chr11:47286290 T/C cg25783544 chr11:47291846 MADD 0.61 7.93 0.44 6.27e-14 HDL cholesterol; CESC cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg09035930 chr12:129282057 SLC15A4 0.69 9.2 0.49 1.1e-17 Systemic lupus erythematosus; CESC cis rs2439831 0.850 rs3736180 chr15:44106624 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.59 0.42 5.34e-13 Lung cancer in ever smokers; CESC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg24549020 chr5:56110836 MAP3K1 0.63 7.27 0.41 4.11e-12 Initial pursuit acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05640416 chr10:135176430 ECHS1 -0.5 -6.01 -0.35 6e-9 Gut microbiome composition (summer); CESC cis rs6964587 0.839 rs13229273 chr7:91444472 G/A cg17063962 chr7:91808500 NA 0.5 6.43 0.37 5.84e-10 Breast cancer; CESC cis rs3747547 0.710 rs7864512 chr9:37949638 G/A cg13774184 chr9:37916125 SHB -0.57 -5.86 -0.34 1.39e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs56104184 0.775 rs17272700 chr19:49391770 G/A cg15549821 chr19:49342101 PLEKHA4 -0.59 -5.82 -0.34 1.7e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.7 0.43 2.77e-13 Prudent dietary pattern; CESC trans rs35110281 0.748 rs4997353 chr21:45002329 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 6.71 0.38 1.18e-10 Mean corpuscular volume; CESC cis rs7264396 0.563 rs6058302 chr20:34290037 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.86 0.39 4.8e-11 Total cholesterol levels; CESC cis rs10911251 0.546 rs1547714 chr1:183114119 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.22 0.63 5.53e-31 Colorectal cancer; CESC cis rs9660992 0.573 rs12144980 chr1:205185104 C/T cg00857998 chr1:205179979 DSTYK 0.53 6.59 0.38 2.35e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs9487051 0.621 rs446974 chr6:109525589 A/C cg01475377 chr6:109611718 NA -0.39 -5.3 -0.31 2.44e-7 Reticulocyte fraction of red cells; CESC cis rs7776786 0.934 rs17349342 chr7:18815473 A/C cg13420273 chr7:18810212 HDAC9 0.34 5.18 0.3 4.42e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs3540 0.514 rs2601192 chr15:90936704 G/A cg22089800 chr15:90895588 ZNF774 0.67 9.33 0.5 4.5e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CESC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg16405210 chr4:1374714 KIAA1530 0.47 5.97 0.34 7.64e-9 Obesity-related traits; CESC cis rs4253772 0.591 rs8135363 chr22:46651713 T/C cg24881330 chr22:46731750 TRMU 0.89 10.09 0.53 1.86e-20 LDL cholesterol;Cholesterol, total; CESC cis rs992157 0.835 rs6707559 chr2:219142773 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.7 9.32 0.5 4.66e-18 Colorectal cancer; CESC cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.55 0.32 6.77e-8 Colonoscopy-negative controls vs population controls; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg22513962 chr8:67976521 CSPP1 -0.46 -6.27 -0.36 1.43e-9 Fibrinogen levels; CESC cis rs3784262 0.934 rs7164408 chr15:58259336 A/G cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.05 -0.3 8.37e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs11650494 0.908 rs73324308 chr17:47405338 T/G cg08112188 chr17:47440006 ZNF652 1.11 7.72 0.43 2.31e-13 Prostate cancer; CESC cis rs11077998 0.869 rs6502123 chr17:80532170 T/C cg10255544 chr17:80519551 FOXK2 0.55 8.73 0.47 2.83e-16 Reticulocyte fraction of red cells; CESC cis rs698833 0.926 rs786407 chr2:44735865 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 6.16 0.35 2.68e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs1881797 0.932 rs10925071 chr1:247686521 C/T cg05639522 chr1:247681581 NA -0.47 -6.68 -0.38 1.42e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs36051895 0.589 rs1322222 chr9:5190444 A/G cg02405213 chr9:5042618 JAK2 -0.55 -6.9 -0.39 3.83e-11 Pediatric autoimmune diseases; CESC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.52 5.81 0.34 1.75e-8 Lung function (FEV1/FVC); CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg01160766 chr17:72199871 RPL38 -0.42 -6.25 -0.36 1.65e-9 Vertical cup-disc ratio; CESC cis rs17401966 1.000 rs4845934 chr1:10468946 G/A cg15208524 chr1:10270712 KIF1B 0.44 5.59 0.32 5.66e-8 Hepatocellular carcinoma; CESC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -10.93 -0.56 3.43e-23 Extrinsic epigenetic age acceleration; CESC cis rs4718428 0.705 rs4718422 chr7:66359269 A/G cg18252515 chr7:66147081 NA -0.46 -5.17 -0.3 4.51e-7 Corneal structure; CESC cis rs2845885 0.793 rs57779243 chr11:63882363 G/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.81 9.49 0.5 1.39e-18 Body mass index; CESC cis rs9900062 0.586 rs2676307 chr17:62690713 C/G cg02598441 chr17:62777298 LOC146880 -0.48 -5.05 -0.3 8.17e-7 QT interval; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03020000 chr10:63662887 ARID5B 0.47 6.83 0.39 5.9e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1878047 0.665 rs34589735 chr19:51775380 T/C cg14884932 chr19:51774451 NA -0.37 -5.16 -0.3 4.87e-7 Body mass index; CESC cis rs2735413 0.875 rs12923229 chr16:78080302 C/A cg04733911 chr16:78082701 NA -0.54 -9.15 -0.49 1.54e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg02461776 chr11:598696 PHRF1 0.51 5.92 0.34 1.01e-8 Systemic lupus erythematosus; CESC cis rs2637266 0.739 rs11001838 chr10:78376351 T/G cg18941641 chr10:78392320 NA -0.34 -5.46 -0.32 1.1e-7 Pulmonary function; CESC cis rs1801251 1.000 rs283480 chr2:233648742 G/A cg25237894 chr2:233734115 C2orf82 0.46 7.81 0.43 1.33e-13 Coronary artery disease; CESC cis rs2708240 1.000 rs2538985 chr7:147580902 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.34 -5.68 -0.33 3.56e-8 QT interval (drug interaction); CESC cis rs12681366 0.734 rs10504936 chr8:95392055 C/T cg13257157 chr8:95487014 RAD54B 0.38 5.11 0.3 6.3e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg07677032 chr17:61819896 STRADA -0.46 -6.18 -0.35 2.44e-9 Prudent dietary pattern; CESC cis rs897984 0.553 rs2335013 chr16:30877346 T/G cg02466173 chr16:30829666 NA 0.47 6.77 0.38 8.11e-11 Dementia with Lewy bodies; CESC cis rs7659604 0.540 rs11734075 chr4:122695685 C/T cg19671926 chr4:122722719 EXOSC9 0.65 8.61 0.47 6.79e-16 Type 2 diabetes; CESC cis rs2599510 0.783 rs13399071 chr2:32793783 C/T cg02381751 chr2:32503542 YIPF4 0.46 5.73 0.33 2.72e-8 Interleukin-18 levels; CESC cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg03676636 chr4:99064102 C4orf37 0.33 5.16 0.3 4.86e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg03467027 chr4:99064603 C4orf37 0.44 5.51 0.32 8.65e-8 Colonoscopy-negative controls vs population controls; CESC cis rs1062177 0.756 rs2964589 chr5:151118189 G/T cg12924095 chr5:151150029 G3BP1 -0.41 -5.16 -0.3 4.87e-7 Preschool internalizing problems; CESC cis rs9925964 0.967 rs9936329 chr16:31140799 G/T cg02466173 chr16:30829666 NA 0.34 5.08 0.3 6.96e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7223966 1.000 rs11654335 chr17:61797579 A/T cg11494091 chr17:61959527 GH2 0.38 5.19 0.3 4.28e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg17971929 chr21:40555470 PSMG1 1.06 16.26 0.71 1.02e-41 Cognitive function; CESC cis rs17253792 0.545 rs12879564 chr14:56017694 A/G cg01858014 chr14:56050164 KTN1 -0.87 -6.37 -0.36 8.34e-10 Putamen volume; CESC cis rs2280018 0.609 rs2941253 chr16:15173746 G/A cg07549590 chr16:15018862 NA -0.52 -8.2 -0.45 1.05e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs4835473 0.932 rs4835471 chr4:144903306 C/T cg25736465 chr4:144833511 NA 0.4 6.12 0.35 3.42e-9 Immature fraction of reticulocytes; CESC cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg14440974 chr22:39074834 NA -0.42 -5.89 -0.34 1.14e-8 Menopause (age at onset); CESC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg19077165 chr18:44547161 KATNAL2 -0.55 -8.24 -0.45 7.77e-15 Personality dimensions; CESC cis rs8072100 0.875 rs12451409 chr17:45544856 A/G cg08085267 chr17:45401833 C17orf57 -0.56 -7.43 -0.42 1.51e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg18404041 chr3:52824283 ITIH1 -0.41 -6.72 -0.38 1.09e-10 Bipolar disorder; CESC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg00129232 chr17:37814104 STARD3 -0.57 -7.72 -0.43 2.35e-13 Glomerular filtration rate (creatinine); CESC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg09365446 chr1:150670422 GOLPH3L 0.42 5.93 0.34 9.63e-9 Tonsillectomy; CESC cis rs2404602 0.647 rs11072625 chr15:77084984 A/G cg23625390 chr15:77176239 SCAPER 0.39 5.25 0.31 3.13e-7 Blood metabolite levels; CESC cis rs6785206 0.667 rs6439139 chr3:128410285 T/C cg16766828 chr3:128327626 NA -0.53 -5.05 -0.3 8.16e-7 Lymphocyte percentage of white cells; CESC cis rs9457247 1.000 rs400176 chr6:167406238 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.89 0.34 1.15e-8 Crohn's disease; CESC cis rs6690583 0.943 rs1837329 chr1:85469614 G/A cg22153463 chr1:85462885 MCOLN2 -0.76 -8.93 -0.48 7.44e-17 Serum sulfate level; CESC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg16325326 chr1:53192061 ZYG11B 0.82 12.7 0.62 3.43e-29 Monocyte count; CESC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.91 9.96 0.52 4.74e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs796364 0.806 rs34510964 chr2:201010676 C/G cg23649088 chr2:200775458 C2orf69 -0.58 -5.71 -0.33 3.07e-8 Schizophrenia; CESC cis rs9929218 0.906 rs9932679 chr16:68751904 A/G cg02972257 chr16:68554789 NA 0.58 6.65 0.38 1.63e-10 Colorectal cancer; CESC cis rs2731664 0.792 rs335467 chr5:176890642 A/G cg23176889 chr5:176863531 GRK6 -0.6 -10.19 -0.53 8.43e-21 Intelligence (multi-trait analysis); CESC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg18252515 chr7:66147081 NA 0.4 5.13 0.3 5.57e-7 Aortic root size; CESC cis rs13385 0.769 rs56997077 chr5:139558412 C/T cg26211634 chr5:139558579 C5orf32 0.47 5.16 0.3 4.77e-7 Atrial fibrillation; CESC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg00074818 chr8:8560427 CLDN23 0.38 5.51 0.32 8.52e-8 Obesity-related traits; CESC cis rs3796352 1.000 rs61172708 chr3:52996052 T/G cg12962167 chr3:53033115 SFMBT1 0.62 5.13 0.3 5.63e-7 Immune reponse to smallpox (secreted IL-2); CESC trans rs208520 0.779 rs208446 chr6:66903515 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.84 -9.54 -0.51 9.64e-19 Exhaled nitric oxide output; CESC cis rs1023500 0.573 rs133374 chr22:42465941 G/A cg15557168 chr22:42548783 NA -0.45 -6.5 -0.37 3.87e-10 Schizophrenia; CESC cis rs4930103 0.904 rs59121562 chr11:2025034 A/T cg23202291 chr11:1979235 NA 0.38 5.73 0.33 2.78e-8 DNA methylation (parent-of-origin);DNA methylation (variation); CESC cis rs909674 0.731 rs6001594 chr22:39837472 C/T cg05872129 chr22:39784769 NA -0.8 -10.43 -0.54 1.49e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08877624 chr8:141521446 CHRAC1 0.6 7.15 0.4 8.21e-12 Gut microbiome composition (summer); CESC cis rs3740713 1.000 rs76599129 chr11:18471627 T/A cg23797887 chr11:18477753 LDHAL6A -0.54 -5.21 -0.31 3.72e-7 Amyotrophic lateral sclerosis (sporadic); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18386867 chr2:39347986 SOS1 0.5 6.09 0.35 3.99e-9 Gut microbiome composition (summer); CESC cis rs3815700 1.000 rs8108840 chr19:33094452 A/C cg24916020 chr19:33096688 ANKRD27 0.58 5.37 0.31 1.69e-7 Eosinophilic esophagitis; CESC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg21784768 chr11:537496 LRRC56 -0.58 -5.29 -0.31 2.62e-7 Body mass index; CESC cis rs7223966 1.000 rs9912904 chr17:61763534 A/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.44 -5.16 -0.3 4.73e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg12292205 chr6:26970375 C6orf41 -0.53 -5.76 -0.33 2.33e-8 Intelligence (multi-trait analysis); CESC cis rs2276314 0.857 rs62101402 chr18:33629435 A/G cg19628046 chr18:33552617 C18orf21 0.5 5.66 0.33 3.84e-8 Endometriosis;Drug-induced torsades de pointes; CESC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg07677032 chr17:61819896 STRADA 0.42 5.33 0.31 2.12e-7 Height; CESC cis rs10851478 0.872 rs11852336 chr15:49948824 T/C cg08060515 chr15:49448048 GALK2;COPS2 0.43 5.28 0.31 2.69e-7 Oral cavity cancer; CESC cis rs9649213 0.614 rs59120980 chr7:98017730 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.45 -6.08 -0.35 4.25e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg17366294 chr4:99064904 C4orf37 0.61 8.52 0.46 1.25e-15 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04094107 chr15:73976560 CD276 0.58 6.47 0.37 4.73e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.58e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12136530 0.651 rs10753561 chr1:19711939 T/C cg15026089 chr1:19640712 PQLC2 0.33 5.08 0.3 7.13e-7 Lead levels in blood; CESC cis rs8072100 0.688 rs12602134 chr17:45582136 C/G cg08085267 chr17:45401833 C17orf57 0.48 6.57 0.37 2.73e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC cis rs12477438 0.765 rs12470471 chr2:99689141 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.62 8.67 0.47 4.33e-16 Chronic sinus infection; CESC trans rs6089829 0.926 rs7273917 chr20:61665975 G/A cg23505145 chr19:12996616 KLF1 0.52 6.78 0.38 7.78e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg00310523 chr12:86230176 RASSF9 0.39 6.12 0.35 3.26e-9 Major depressive disorder; CESC cis rs9660992 0.674 rs17345816 chr1:205262868 A/T cg21643547 chr1:205240462 TMCC2 0.47 6.26 0.36 1.54e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs12971120 0.891 rs3764510 chr18:72166846 A/G cg26446133 chr18:72167187 CNDP2 -0.77 -9.41 -0.5 2.5e-18 Refractive error; CESC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.99 -17.01 -0.72 2.37e-44 Prudent dietary pattern; CESC cis rs17539620 0.624 rs62432739 chr6:154835926 A/G cg17771515 chr6:154831774 CNKSR3 0.59 5.85 0.34 1.43e-8 Lipoprotein (a) levels; CESC cis rs977987 0.778 rs2865528 chr16:75455942 T/C cg03315344 chr16:75512273 CHST6 0.41 5.98 0.34 7.31e-9 Dupuytren's disease; CESC cis rs9463078 0.774 rs4510673 chr6:45350107 A/G cg25276700 chr6:44698697 NA 0.34 5.06 0.3 8.02e-7 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CESC cis rs9303401 0.661 rs9902820 chr17:56637545 A/C cg12560992 chr17:57184187 TRIM37 0.56 7.18 0.4 6.88e-12 Cognitive test performance; CESC cis rs67460515 0.567 rs34691229 chr3:160876897 G/T cg03342759 chr3:160939853 NMD3 -0.54 -6.92 -0.39 3.36e-11 Parkinson's disease; CESC cis rs9611565 0.512 rs1534932 chr22:42150146 C/T cg06481639 chr22:41940642 POLR3H 0.62 6.14 0.35 2.97e-9 Vitiligo; CESC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg21280719 chr6:42927975 GNMT -0.29 -6.72 -0.38 1.14e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1153858 0.621 rs2687512 chr15:45581495 T/C cg14582100 chr15:45693742 SPATA5L1 -0.41 -5.49 -0.32 9.63e-8 Homoarginine levels; CESC cis rs4253772 0.938 rs77378083 chr22:46639386 G/A cg00784671 chr22:46762841 CELSR1 -0.57 -5.6 -0.33 5.29e-8 LDL cholesterol;Cholesterol, total; CESC cis rs4974559 0.594 rs11946384 chr4:1313566 T/C cg02980000 chr4:1222292 CTBP1 0.62 7.25 0.41 4.59e-12 Systolic blood pressure; CESC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg13114125 chr14:105738426 BRF1 -0.85 -10.46 -0.54 1.18e-21 Mean platelet volume;Platelet distribution width; CESC cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg08213375 chr14:104286397 PPP1R13B 0.33 5.41 0.32 1.4e-7 Reticulocyte count; CESC cis rs7249142 0.512 rs12981160 chr19:19298099 T/A cg27384695 chr19:19271486 LOC729991-MEF2B;MEF2B 0.29 5.09 0.3 6.78e-7 IgG glycosylation; CESC cis rs10883723 0.773 rs1326193 chr10:104271674 G/T cg22532475 chr10:104410764 TRIM8 -0.35 -5.9 -0.34 1.13e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs916888 0.773 rs199535 chr17:44822662 A/G cg15921436 chr17:44337874 NA 0.76 8.49 0.46 1.53e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6690583 0.562 rs12024977 chr1:85531051 A/C cg22153463 chr1:85462885 MCOLN2 0.7 6.93 0.39 3.23e-11 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09212610 chr15:90892496 GABARAPL3 -0.6 -6.94 -0.39 3.09e-11 Gut microbiome composition (summer); CESC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs7527798 0.614 rs11118253 chr1:207825469 G/C cg21110645 chr1:207815933 NA -0.33 -5.88 -0.34 1.21e-8 Erythrocyte sedimentation rate; CESC cis rs8060686 0.641 rs8059305 chr16:68036666 A/C cg26727032 chr16:67993705 SLC12A4 -0.52 -7.2 -0.4 6.08e-12 HDL cholesterol;Metabolic syndrome; CESC cis rs7267979 0.903 rs6050482 chr20:25226327 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.8 15.59 0.69 2.47e-39 Liver enzyme levels (alkaline phosphatase); CESC trans rs352242 0.726 rs975097 chr13:69871862 A/T cg15456293 chr8:2044148 MYOM2 -0.36 -6.02 -0.35 5.76e-9 Life satisfaction; CESC cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 5.67 0.33 3.81e-8 Colorectal cancer; CESC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg22143856 chr6:28129313 ZNF389 0.53 6.71 0.38 1.2e-10 Parkinson's disease; CESC cis rs4595586 0.546 rs2056159 chr12:39270417 C/G cg13010199 chr12:38710504 ALG10B 0.58 7.71 0.43 2.47e-13 Morning vs. evening chronotype; CESC cis rs9584850 0.874 rs3742137 chr13:99102449 C/T cg20750642 chr13:99100586 FARP1 -0.39 -5.85 -0.34 1.45e-8 Neuroticism; CESC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg06634786 chr22:41940651 POLR3H 0.58 6.21 0.36 2.04e-9 Vitiligo; CESC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg23283495 chr1:209979779 IRF6 0.52 7.42 0.41 1.62e-12 Cleft lip with or without cleft palate; CESC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.35 -0.57 1.31e-24 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17847749 chr12:116355168 NA -0.61 -7.03 -0.4 1.71e-11 Gut microbiome composition (summer); CESC cis rs6570726 1.000 rs405622 chr6:145871897 G/T cg23711669 chr6:146136114 FBXO30 0.77 11.24 0.57 3.15e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg12311346 chr5:56204834 C5orf35 -0.43 -5.38 -0.31 1.64e-7 Coronary artery disease; CESC cis rs11098499 0.874 rs28452522 chr4:120110784 A/G cg09307838 chr4:120376055 NA 0.65 7.83 0.43 1.17e-13 Corneal astigmatism; CESC cis rs561341 1.000 rs546748 chr17:30324293 A/C cg12193833 chr17:30244370 NA -0.53 -6.0 -0.35 6.57e-9 Hip circumference adjusted for BMI; CESC cis rs9325144 0.647 rs12830095 chr12:38864199 C/T cg26384229 chr12:38710491 ALG10B -0.56 -7.89 -0.44 8.02e-14 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04677326 chr19:3557664 C19orf28 0.56 6.86 0.39 4.93e-11 Gut microbiome composition (summer); CESC cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg19717773 chr7:2847554 GNA12 -0.57 -8.87 -0.48 1.11e-16 Height; CESC cis rs453301 0.686 rs2409120 chr8:8882571 G/C cg15556689 chr8:8085844 FLJ10661 -0.49 -5.94 -0.34 9.08e-9 Joint mobility (Beighton score); CESC cis rs9549367 0.789 rs2287250 chr13:113889474 C/T cg18105134 chr13:113819100 PROZ 0.6 7.49 0.42 1.04e-12 Platelet distribution width; CESC cis rs7481584 0.624 rs412842 chr11:3047448 A/G cg08508325 chr11:3079039 CARS 0.29 5.08 0.3 7.06e-7 Calcium levels; CESC cis rs7640424 0.649 rs13091474 chr3:107877134 A/T cg09227934 chr3:107805635 CD47 -0.44 -5.67 -0.33 3.75e-8 Body mass index; CESC cis rs1843834 0.539 rs6713629 chr2:225410973 A/T cg22509189 chr2:225307070 NA -0.4 -5.39 -0.31 1.58e-7 IgE levels in asthmatics (D.p. specific); CESC cis rs1878931 0.624 rs37810 chr16:3451881 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.81 -9.94 -0.52 5.62e-20 Body mass index (adult); CESC cis rs4974559 0.690 rs28515563 chr4:1315123 G/A cg02980000 chr4:1222292 CTBP1 0.79 7.35 0.41 2.44e-12 Systolic blood pressure; CESC cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg26408565 chr15:76604113 ETFA 0.39 5.91 0.34 1.05e-8 Blood metabolite levels; CESC cis rs7560272 0.512 rs4530394 chr2:73929650 T/C cg20560298 chr2:73613845 ALMS1 0.45 6.17 0.35 2.52e-9 Schizophrenia; CESC cis rs1144333 1.000 rs60144605 chr1:76359699 A/C cg10523679 chr1:76189770 ACADM 0.56 5.31 0.31 2.27e-7 Attention function in attention deficit hyperactive disorder; CESC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 10.33 0.54 3.05e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs1996720 0.958 rs2353254 chr8:113068212 A/G cg02687417 chr20:43977232 SDC4 0.46 5.99 0.35 6.64e-9 Temperament; CESC cis rs763121 0.962 rs6001193 chr22:39074737 A/G cg06022373 chr22:39101656 GTPBP1 0.8 13.36 0.63 1.76e-31 Menopause (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg23116115 chr4:1004261 FGFRL1 -0.46 -6.12 -0.35 3.4e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg11764359 chr7:65958608 NA 0.67 8.6 0.47 7.12e-16 Calcium levels; CESC cis rs2075371 1.000 rs2598296 chr7:133992985 C/T cg11752832 chr7:134001865 SLC35B4 0.55 7.16 0.4 8.05e-12 Mean platelet volume; CESC cis rs62064224 0.720 rs8078837 chr17:30763537 A/G cg18200150 chr17:30822561 MYO1D 0.73 11.72 0.58 7.69e-26 Schizophrenia; CESC cis rs6867032 0.527 rs13153217 chr5:2012788 G/T cg26168224 chr5:2018326 NA -0.6 -9.18 -0.49 1.24e-17 Gut microbiome composition (winter); CESC cis rs9325144 0.505 rs7138977 chr12:38642109 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.35 0.36 9.31e-10 Morning vs. evening chronotype; CESC cis rs684232 0.623 rs12601935 chr17:519325 G/A cg12384639 chr17:618140 VPS53 0.43 5.51 0.32 8.37e-8 Prostate cancer; CESC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg25427524 chr10:38739819 LOC399744 -0.67 -9.8 -0.52 1.46e-19 Extrinsic epigenetic age acceleration; CESC cis rs77956314 0.515 rs7302025 chr12:117442902 C/T cg16111737 chr12:117408163 FBXW8 -0.46 -5.72 -0.33 2.87e-8 Subcortical brain region volumes;Hippocampal volume; CESC cis rs4835473 0.932 rs34617134 chr4:144904759 T/C cg25736465 chr4:144833511 NA 0.41 6.16 0.35 2.72e-9 Immature fraction of reticulocytes; CESC cis rs3733418 0.860 rs869867 chr4:165930747 C/G cg10852876 chr4:165953100 TRIM60 -0.51 -6.01 -0.35 6.03e-9 Obesity-related traits; CESC cis rs10838687 0.800 rs3729805 chr11:47352757 C/T cg25783544 chr11:47291846 MADD 0.55 6.23 0.36 1.8e-9 Proinsulin levels; CESC cis rs6456156 0.586 rs13210649 chr6:167473193 T/G cg07741184 chr6:167504864 NA 0.37 6.39 0.37 7.28e-10 Primary biliary cholangitis; CESC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg22920501 chr2:26401640 FAM59B 0.91 10.33 0.54 3.07e-21 Gut microbiome composition (summer); CESC cis rs10242455 0.702 rs78080383 chr7:99064465 C/T cg18809830 chr7:99032528 PTCD1 -0.84 -5.61 -0.33 5e-8 Blood metabolite levels; CESC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg26338869 chr17:61819248 STRADA -0.63 -8.19 -0.45 1.12e-14 Prudent dietary pattern; CESC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg06028605 chr16:24865363 SLC5A11 0.55 8.35 0.46 3.75e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs7208859 0.623 rs11650271 chr17:29213943 C/T cg13385521 chr17:29058706 SUZ12P 0.66 5.03 0.3 9.15e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs3126085 0.935 rs12144058 chr1:152170216 C/T cg26876637 chr1:152193138 HRNR 0.44 5.04 0.3 8.68e-7 Atopic dermatitis; CESC cis rs35110281 0.743 rs230640 chr21:44914815 A/T cg04455712 chr21:45112962 RRP1B -0.38 -5.71 -0.33 3.08e-8 Mean corpuscular volume; CESC trans rs61931739 0.500 rs7489132 chr12:34539712 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg27266027 chr21:40555129 PSMG1 0.48 5.86 0.34 1.37e-8 Cognitive function; CESC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg09323728 chr8:95962352 TP53INP1 -0.37 -7.93 -0.44 6.24e-14 Type 2 diabetes; CESC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg14159672 chr1:205819179 PM20D1 0.8 11.64 0.58 1.39e-25 Menarche (age at onset); CESC cis rs933688 1.000 rs6862125 chr5:90724598 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.17 15.64 0.69 1.6e-39 Smoking behavior; CESC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg05564831 chr3:52568323 NT5DC2 0.46 7.38 0.41 2.06e-12 Bipolar disorder; CESC cis rs12477438 0.765 rs7607578 chr2:99669771 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs6141600 0.760 rs2746097 chr20:34672923 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -5.56 -0.32 6.63e-8 Height;Hip circumference; CESC trans rs656319 0.625 rs4526366 chr8:9890179 C/G cg06636001 chr8:8085503 FLJ10661 -0.55 -6.49 -0.37 4.22e-10 Myopia (pathological); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18788524 chr1:145096602 SEC22B -0.47 -6.22 -0.36 1.98e-9 Fibrinogen levels; CESC cis rs2243480 1.000 rs35735127 chr7:65300423 G/T cg12463550 chr7:65579703 CRCP 0.68 5.74 0.33 2.59e-8 Diabetic kidney disease; CESC cis rs1018836 0.923 rs2105965 chr8:91537690 T/C cg16814680 chr8:91681699 NA -0.74 -11.22 -0.57 3.66e-24 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs1594829 0.553 rs2046226 chr8:26152050 G/A cg11498726 chr8:26250323 BNIP3L -0.4 -6.06 -0.35 4.68e-9 Height; CESC cis rs7143963 0.666 rs2403102 chr14:103306215 C/T cg24154132 chr14:103367632 TRAF3 0.35 6.35 0.36 9.56e-10 Body mass index; CESC cis rs1425132 0.642 rs2033044 chr7:37589834 A/C cg15028436 chr7:37888078 TXNDC3 -0.31 -5.13 -0.3 5.63e-7 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin); CESC cis rs6912958 0.712 rs2754260 chr6:88397666 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -7.05 -0.4 1.55e-11 Monocyte percentage of white cells; CESC cis rs2204008 0.682 rs2320517 chr12:38259239 A/T cg13010199 chr12:38710504 ALG10B 0.52 6.38 0.36 8.04e-10 Bladder cancer; CESC cis rs936229 0.749 rs8031937 chr15:75181121 A/G cg14664628 chr15:75095509 CSK -0.72 -9.05 -0.49 3.28e-17 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs9815354 1.000 rs13325965 chr3:41914942 G/T cg03022575 chr3:42003672 ULK4 0.59 5.91 0.34 1.08e-8 Pulse pressure;Diastolic blood pressure; CESC cis rs2243480 0.803 rs34004500 chr7:65312178 A/T cg12463550 chr7:65579703 CRCP 0.68 5.73 0.33 2.72e-8 Diabetic kidney disease; CESC cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.47 6.19 0.36 2.31e-9 Personality dimensions; CESC cis rs12477438 0.748 rs7558239 chr2:99640581 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.57 -0.54 5.22e-22 Chronic sinus infection; CESC cis rs9287719 0.746 rs6742448 chr2:10759126 G/A cg02196655 chr2:10830764 NOL10 -0.36 -5.59 -0.32 5.58e-8 Prostate cancer; CESC cis rs9486719 1.000 rs2472884 chr6:96863965 C/T cg18709589 chr6:96969512 KIAA0776 0.52 5.67 0.33 3.8e-8 Migraine;Coronary artery disease; CESC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg24549020 chr5:56110836 MAP3K1 0.64 7.32 0.41 3.05e-12 Initial pursuit acceleration; CESC cis rs6032067 0.777 rs35476703 chr20:43802875 C/G cg10761708 chr20:43804764 PI3 0.56 6.65 0.38 1.7e-10 Blood protein levels; CESC cis rs765787 0.530 rs4514617 chr15:45535439 A/G cg24006582 chr15:45444508 DUOX1 -0.51 -6.43 -0.37 6.05e-10 Uric acid levels; CESC cis rs9300255 0.602 rs1716172 chr12:123712712 G/T cg05973401 chr12:123451056 ABCB9 0.5 5.65 0.33 4.1e-8 Neutrophil percentage of white cells; CESC cis rs6570726 0.935 rs447818 chr6:145868996 C/T cg23711669 chr6:146136114 FBXO30 0.79 11.47 0.58 5.24e-25 Lobe attachment (rater-scored or self-reported); CESC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg17724175 chr1:150552817 MCL1 0.45 7.41 0.41 1.71e-12 Tonsillectomy; CESC trans rs35110281 0.774 rs9978811 chr21:44998683 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 6.49 0.37 4.14e-10 Mean corpuscular volume; CESC cis rs9818758 0.607 rs80170003 chr3:48951640 T/C cg00383909 chr3:49044727 WDR6 0.93 6.36 0.36 8.7e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC cis rs2479724 0.840 rs6925777 chr6:41750822 C/T cg08135965 chr6:41755394 TOMM6 -0.41 -5.54 -0.32 7.45e-8 Menarche (age at onset); CESC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.63 -8.19 -0.45 1.15e-14 Tonsillectomy; CESC cis rs9811920 0.809 rs6802817 chr3:99779264 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.45 -7.44 -0.42 1.38e-12 Axial length; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00711596 chr19:2115281 AP3D1 0.45 6.04 0.35 5.26e-9 Fibrinogen levels; CESC cis rs7605827 0.930 rs4668447 chr2:15516166 T/C cg19274914 chr2:15703543 NA 0.32 5.55 0.32 6.84e-8 Educational attainment (years of education); CESC cis rs9611565 0.681 rs6002372 chr22:41801299 A/T cg03806693 chr22:41940476 POLR3H 1.09 12.57 0.61 9.68e-29 Vitiligo; CESC cis rs17376456 0.825 rs13361613 chr5:93272176 C/T cg17533458 chr5:92956826 FAM172A;MIR2277 0.65 5.32 0.31 2.26e-7 Diabetic retinopathy; CESC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg05313129 chr8:58192883 C8orf71 -0.54 -6.22 -0.36 1.94e-9 Developmental language disorder (linguistic errors); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg15043926 chr4:26863112 STIM2 -0.4 -6.45 -0.37 5.23e-10 Gambling; CESC cis rs9549260 0.848 rs966968 chr13:41248037 C/T cg21288729 chr13:41239152 FOXO1 -0.66 -8.67 -0.47 4.54e-16 Red blood cell count; CESC cis rs61841072 0.961 rs1985630 chr1:243134694 T/C cg02356786 chr1:243265016 LOC731275 0.43 5.62 0.33 4.85e-8 Schizophrenia; CESC cis rs67478160 0.643 rs6575999 chr14:104250609 C/G cg08213375 chr14:104286397 PPP1R13B 0.55 10.79 0.55 9.83e-23 Schizophrenia; CESC cis rs4319547 0.656 rs7975747 chr12:122816995 C/T cg05707623 chr12:122985044 ZCCHC8 -0.5 -5.73 -0.33 2.66e-8 Body mass index; CESC trans rs7824557 0.564 rs2736302 chr8:11236419 T/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.15 -0.35 2.9e-9 Retinal vascular caliber; CESC cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg12386194 chr3:101231763 SENP7 0.41 5.11 0.3 6.03e-7 Colorectal cancer; CESC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg18016565 chr1:150552671 MCL1 0.33 5.07 0.3 7.65e-7 Tonsillectomy; CESC cis rs11098499 0.657 rs9996569 chr4:120299004 G/C cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg06420487 chr17:61919686 SMARCD2 0.44 5.31 0.31 2.36e-7 Height; CESC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg06873352 chr17:61820015 STRADA 0.46 6.76 0.38 8.73e-11 Height; CESC trans rs1994135 0.654 rs11052759 chr12:33724126 G/A cg26384229 chr12:38710491 ALG10B 0.58 7.82 0.43 1.26e-13 Resting heart rate; CESC cis rs763121 0.853 rs2281020 chr22:39064406 A/G cg21395723 chr22:39101663 GTPBP1 0.43 5.39 0.31 1.58e-7 Menopause (age at onset); CESC trans rs6665290 0.935 rs6704144 chr1:227201030 C/G cg02597199 chr15:101098829 NA -0.46 -6.07 -0.35 4.34e-9 Myeloid white cell count; CESC cis rs12900413 0.687 rs12906905 chr15:90315399 A/G cg24249390 chr15:90295951 MESP1 -0.41 -5.73 -0.33 2.78e-8 Coronary artery aneurysm in Kawasaki disease; CESC cis rs7267979 1.000 rs2257496 chr20:25279315 A/G cg08601574 chr20:25228251 PYGB 0.39 5.57 0.32 6.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs3733585 0.673 rs4580649 chr4:9948461 G/A cg11266682 chr4:10021025 SLC2A9 -0.59 -11.25 -0.57 2.88e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs9303401 0.646 rs8067682 chr17:57219391 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.56 7.33 0.41 2.74e-12 Cognitive test performance; CESC cis rs7584330 0.910 rs66509917 chr2:238395394 T/G cg11271282 chr2:238384023 NA 0.43 5.09 0.3 6.66e-7 Prostate cancer; CESC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg22143856 chr6:28129313 ZNF389 0.49 6.24 0.36 1.73e-9 Depression; CESC cis rs9733 1.000 rs9733 chr1:150618961 A/C cg13175981 chr1:150552382 MCL1 0.54 7.35 0.41 2.5e-12 Tonsillectomy; CESC cis rs1153858 1.000 rs7181167 chr15:45686236 C/G cg14582100 chr15:45693742 SPATA5L1 0.42 5.88 0.34 1.22e-8 Homoarginine levels; CESC cis rs9976767 0.637 rs2156309 chr21:43824529 G/A cg23042151 chr21:43824109 UBASH3A -0.34 -6.38 -0.36 8.06e-10 Type 1 diabetes; CESC cis rs1050631 0.592 rs1785921 chr18:33737196 A/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.54 7.31 0.41 3.24e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs826838 0.935 rs11169508 chr12:39173385 C/T cg13010199 chr12:38710504 ALG10B 0.57 7.86 0.43 9.51e-14 Heart rate; CESC trans rs116095464 0.558 rs9654452 chr5:299561 C/T cg00938859 chr5:1591904 SDHAP3 0.65 7.04 0.4 1.67e-11 Breast cancer; CESC cis rs6088590 0.561 rs764597 chr20:33161225 C/T cg24642439 chr20:33292090 TP53INP2 0.61 8.29 0.45 5.79e-15 Coronary artery disease; CESC cis rs7254114 0.578 rs7246614 chr19:11310538 C/T cg02815516 chr19:11306319 KANK2 -0.42 -6.77 -0.38 8.32e-11 Immature fraction of reticulocytes; CESC cis rs7659604 0.702 rs58649165 chr4:122693752 C/A cg19748678 chr4:122722346 EXOSC9 0.65 8.51 0.46 1.27e-15 Type 2 diabetes; CESC cis rs11828289 0.660 rs17306426 chr11:23222079 G/T cg20040320 chr11:23191996 NA 0.72 6.19 0.36 2.23e-9 Cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg22542702 chr2:132384461 NA -0.38 -6.29 -0.36 1.3e-9 Asthma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06710176 chr12:25347973 CASC1;LYRM5 -0.53 -6.11 -0.35 3.61e-9 Gut microbiome composition (summer); CESC cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg12927641 chr6:109611667 NA -0.43 -6.62 -0.38 2e-10 Reticulocyte fraction of red cells; CESC cis rs11051970 0.592 rs11051985 chr12:32555090 G/A cg24626660 chr12:32551988 NA 0.36 5.27 0.31 2.77e-7 Response to tocilizumab in rheumatoid arthritis; CESC cis rs9359856 0.564 rs56396054 chr6:90360406 C/T cg13799429 chr6:90582589 CASP8AP2 -0.65 -6.23 -0.36 1.83e-9 Bipolar disorder; CESC cis rs10883723 0.810 rs2281879 chr10:104268877 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.57 8.01 0.44 3.69e-14 Allergic disease (asthma, hay fever or eczema); CESC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.02 -0.4 1.84e-11 Personality dimensions; CESC cis rs2180341 1.000 rs9398837 chr6:127635217 G/A cg24812749 chr6:127587940 RNF146 1.07 15.48 0.69 6.31e-39 Breast cancer; CESC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg21248554 chr2:27665150 KRTCAP3 -0.35 -7.19 -0.4 6.72e-12 Total body bone mineral density; CESC cis rs11792861 0.781 rs838835 chr9:111758590 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.59 -8.18 -0.45 1.18e-14 Menarche (age at onset); CESC cis rs7589342 0.628 rs62152201 chr2:106411664 C/T cg16077055 chr2:106428750 NCK2 0.55 7.0 0.39 2.12e-11 Addiction; CESC cis rs9399135 0.935 rs4445070 chr6:135309212 C/T cg24558204 chr6:135376177 HBS1L 0.49 6.5 0.37 4.05e-10 Red blood cell count; CESC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg13395646 chr4:1353034 KIAA1530 -0.53 -6.56 -0.37 2.81e-10 Obesity-related traits; CESC trans rs2727020 0.521 rs7114564 chr11:49571231 C/T cg15704280 chr7:45808275 SEPT13 0.82 10.08 0.53 2.01e-20 Coronary artery disease; CESC cis rs287982 1.000 rs2656329 chr2:9968344 C/T cg10881225 chr2:9984929 TAF1B 0.4 5.03 0.3 9.11e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs1969363 0.509 rs8189633 chr12:38065155 C/G cg13010199 chr12:38710504 ALG10B 0.54 6.69 0.38 1.28e-10 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06130365 chr10:135122020 TUBGCP2;ZNF511 0.55 6.05 0.35 5.03e-9 Gut microbiome composition (summer); CESC cis rs7264396 0.676 rs6060727 chr20:34556000 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.52 6.18 0.36 2.37e-9 Total cholesterol levels; CESC cis rs4466137 0.794 rs6869296 chr5:83007333 C/G cg16102102 chr5:83017553 HAPLN1 0.44 6.33 0.36 1.06e-9 Prostate cancer; CESC cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.62e-7 Colonoscopy-negative controls vs population controls; CESC cis rs72781680 0.716 rs2712068 chr2:23984000 A/G cg08917208 chr2:24149416 ATAD2B 0.61 5.95 0.34 8.33e-9 Lymphocyte counts; CESC cis rs703842 0.892 rs1021469 chr12:58208164 C/T cg18357645 chr12:58087776 OS9 -0.42 -5.84 -0.34 1.54e-8 Multiple sclerosis; CESC cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg05340658 chr4:99064831 C4orf37 0.79 12.26 0.6 1.12e-27 Colonoscopy-negative controls vs population controls; CESC cis rs4803468 1.000 rs4674 chr19:41930396 A/G cg14132834 chr19:41945861 ATP5SL -0.65 -7.92 -0.44 6.5e-14 Height; CESC cis rs13082711 0.911 rs13082777 chr3:27421942 A/G cg02860705 chr3:27208620 NA 0.51 6.21 0.36 2.02e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7116495 1.000 rs6592453 chr11:71683231 C/G cg26138937 chr11:71823887 C11orf51 -0.8 -6.51 -0.37 3.81e-10 Severe influenza A (H1N1) infection; CESC trans rs9325144 0.624 rs12231544 chr12:38901956 C/T cg23762105 chr12:34175262 ALG10 0.47 6.08 0.35 4.1e-9 Morning vs. evening chronotype; CESC cis rs68170813 0.559 rs7803290 chr7:106907353 T/C cg02696742 chr7:106810147 HBP1 -0.52 -5.09 -0.3 6.84e-7 Coronary artery disease; CESC cis rs7772486 0.790 rs2253654 chr6:146199445 T/C cg05347473 chr6:146136440 FBXO30 0.6 7.75 0.43 1.94e-13 Lobe attachment (rater-scored or self-reported); CESC cis rs854765 0.619 rs4561528 chr17:17979099 C/T cg16928487 chr17:17741425 SREBF1 -0.56 -9.3 -0.5 5.51e-18 Total body bone mineral density; CESC cis rs2299587 0.554 rs2073564 chr8:17743341 G/A cg08627089 chr8:17753878 FGL1 -0.4 -5.75 -0.33 2.42e-8 Economic and political preferences; CESC cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg03709012 chr19:19516395 GATAD2A 1.01 15.7 0.69 1.02e-39 Tonsillectomy; CESC cis rs897984 0.609 rs57576577 chr16:31036367 G/A cg00531865 chr16:30841666 NA -0.4 -5.59 -0.32 5.78e-8 Dementia with Lewy bodies; CESC cis rs113835537 0.935 rs117131621 chr11:66422334 C/T cg22134325 chr11:66188745 NPAS4 0.51 5.84 0.34 1.55e-8 Airway imaging phenotypes; CESC cis rs6570726 0.791 rs9373466 chr6:145912016 T/C cg05347473 chr6:146136440 FBXO30 0.57 7.44 0.42 1.37e-12 Lobe attachment (rater-scored or self-reported); CESC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg21784768 chr11:537496 LRRC56 -0.54 -5.11 -0.3 6.31e-7 Body mass index; CESC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg04369109 chr6:150039330 LATS1 -0.43 -5.91 -0.34 1.05e-8 Lung cancer; CESC cis rs7208859 0.623 rs216434 chr17:28922335 G/C cg14008862 chr17:28927542 LRRC37B2 0.76 5.68 0.33 3.49e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.91 -13.91 -0.65 2.14e-33 Prudent dietary pattern; CESC cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.87 8.72 0.47 3.16e-16 Schizophrenia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12819747 chr12:112622701 C12orf51 -0.45 -6.39 -0.37 7.56e-10 Systemic lupus erythematosus; CESC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg09509183 chr1:209979624 IRF6 0.5 6.32 0.36 1.1e-9 Cleft lip with or without cleft palate; CESC cis rs4780401 0.609 rs7205994 chr16:11815964 C/T cg01061890 chr16:11836724 TXNDC11 -0.56 -7.52 -0.42 8.36e-13 Rheumatoid arthritis; CESC cis rs12541635 0.966 rs12674846 chr8:107007178 A/G cg10147462 chr8:107024639 NA 0.42 5.96 0.34 7.89e-9 Age of smoking initiation; CESC cis rs7089973 0.872 rs17092542 chr10:116630289 G/A cg23260525 chr10:116636907 FAM160B1 0.37 6.3 0.36 1.27e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg07936489 chr17:37558343 FBXL20 0.77 11.23 0.57 3.4e-24 Glomerular filtration rate (creatinine); CESC cis rs17001868 0.568 rs9607699 chr22:40737036 G/A cg07138101 chr22:40742427 ADSL 0.57 5.38 0.31 1.66e-7 Mammographic density (dense area); CESC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg24531977 chr5:56204891 C5orf35 -0.78 -9.72 -0.51 2.74e-19 Initial pursuit acceleration; CESC cis rs2841277 0.676 rs4264326 chr14:105411700 A/G cg15352829 chr14:105391018 PLD4 -0.6 -10.51 -0.54 7.92e-22 Rheumatoid arthritis; CESC cis rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25730142 chr20:32031702 SNTA1 -0.43 -5.52 -0.32 7.97e-8 Ulcerative colitis; CESC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.99 9.32 0.5 4.59e-18 Platelet count; CESC trans rs3749237 1.000 rs11130214 chr3:49735746 C/G cg21659725 chr3:3221576 CRBN -0.53 -6.34 -0.36 1e-9 Resting heart rate; CESC cis rs7945705 0.776 rs2316865 chr11:8815470 A/G cg12365402 chr11:9010492 NRIP3 0.33 5.07 0.3 7.56e-7 Hemoglobin concentration; CESC cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg10556349 chr10:835070 NA 0.77 6.42 0.37 6.09e-10 Eosinophil percentage of granulocytes; CESC cis rs9291683 0.510 rs4318649 chr4:10016815 T/C cg11266682 chr4:10021025 SLC2A9 0.68 13.13 0.63 1.13e-30 Bone mineral density; CESC cis rs367615 0.704 rs4320313 chr5:108828687 A/G cg17395555 chr5:108820864 NA 0.65 11.29 0.57 2.17e-24 Colorectal cancer (SNP x SNP interaction); CESC trans rs2727020 0.729 rs1164666 chr11:49295867 C/T cg03929089 chr4:120376271 NA -0.78 -11.94 -0.59 1.38e-26 Coronary artery disease; CESC cis rs10489202 0.955 rs17557162 chr1:167985950 A/T cg24449463 chr1:168025552 DCAF6 0.48 5.51 0.32 8.47e-8 Schizophrenia; CESC cis rs9300255 0.596 rs1727331 chr12:123718879 C/G cg05973401 chr12:123451056 ABCB9 -0.44 -5.5 -0.32 9.15e-8 Neutrophil percentage of white cells; CESC cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg10523679 chr1:76189770 ACADM 0.67 7.54 0.42 7.39e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg21926612 chr6:163149169 PACRG;PARK2 0.77 8.1 0.45 1.99e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs4243830 0.850 rs57203351 chr1:6601319 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 0.99 9.97 0.52 4.34e-20 Body mass index; CESC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.68 -0.51 3.46e-19 Alzheimer's disease; CESC cis rs9291683 0.609 rs13149985 chr4:10028390 G/A cg02734326 chr4:10020555 SLC2A9 0.46 6.41 0.37 6.67e-10 Bone mineral density; CESC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg02187348 chr16:89574699 SPG7 0.65 9.03 0.49 3.66e-17 Multiple myeloma (IgH translocation); CESC trans rs3756309 1.000 rs3756309 chr5:149505624 C/T cg11703470 chr6:99276280 NA 0.38 6.07 0.35 4.46e-9 Blood protein levels; CESC cis rs7084402 1.000 rs7095501 chr10:60271940 T/C cg07615347 chr10:60278583 BICC1 -0.57 -8.78 -0.47 2.13e-16 Refractive error; CESC cis rs56399783 0.901 rs11971014 chr7:2778444 C/T cg19731401 chr7:2775893 GNA12 0.64 5.85 0.34 1.43e-8 Childhood ear infection; CESC cis rs9911578 0.935 rs2302189 chr17:56584205 A/C cg05425664 chr17:57184151 TRIM37 0.51 6.91 0.39 3.63e-11 Intelligence (multi-trait analysis); CESC cis rs10089 1.000 rs4835945 chr5:127526481 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 9.35 0.5 3.9e-18 Ileal carcinoids; CESC cis rs7607369 0.791 rs12468043 chr2:219354197 C/A cg02176678 chr2:219576539 TTLL4 0.5 8.98 0.48 5.22e-17 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs854765 0.587 rs4077828 chr17:17833644 A/T cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.9e-9 Total body bone mineral density; CESC cis rs7647973 0.588 rs9883000 chr3:49667691 A/G cg06212747 chr3:49208901 KLHDC8B 0.65 7.77 0.43 1.78e-13 Menarche (age at onset); CESC cis rs13256369 0.802 rs34762800 chr8:8559294 G/A cg00074818 chr8:8560427 CLDN23 0.38 5.34 0.31 2.05e-7 Obesity-related traits; CESC cis rs11098499 0.754 rs17049949 chr4:120255290 A/G cg09307838 chr4:120376055 NA 0.8 10.88 0.56 5.04e-23 Corneal astigmatism; CESC cis rs35160687 0.623 rs11127021 chr2:86474919 C/T cg01119172 chr2:86362222 SNORD94;PTCD3 -0.39 -5.18 -0.3 4.5e-7 Night sleep phenotypes; CESC trans rs4596713 0.507 rs10869975 chr9:71795034 C/T cg16512924 chr15:28394682 HERC2 -0.5 -6.13 -0.35 3.2e-9 Headache; CESC cis rs9788682 0.706 rs924840 chr15:78731808 A/T cg06917634 chr15:78832804 PSMA4 -0.45 -5.03 -0.3 9.22e-7 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs9640161 0.789 rs1464753 chr7:150021350 G/C cg21361702 chr7:150065534 REPIN1 0.5 5.72 0.33 2.8e-8 Blood protein levels;Circulating chemerin levels; CESC cis rs701145 0.556 rs355758 chr3:154007682 C/G cg16511985 chr3:153974050 SGEF -0.4 -5.53 -0.32 7.76e-8 Coronary artery disease; CESC cis rs858239 0.539 rs2103281 chr7:23194231 A/G cg23682824 chr7:23144976 KLHL7 0.45 5.87 0.34 1.29e-8 Cerebrospinal fluid biomarker levels; CESC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg01448562 chr3:133502909 NA 0.43 6.02 0.35 5.65e-9 Iron status biomarkers; CESC cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg00934597 chr7:893267 UNC84A -0.5 -6.62 -0.38 1.98e-10 Perceived unattractiveness to mosquitoes; CESC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg26335602 chr6:28129616 ZNF389 0.53 7.09 0.4 1.19e-11 Depression; CESC cis rs6582630 0.555 rs11182422 chr12:38522833 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.97 0.34 7.53e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.87 -0.34 1.27e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg23172400 chr8:95962367 TP53INP1 -0.46 -9.59 -0.51 6.82e-19 Type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13148496 chr14:103430618 CDC42BPB -0.56 -6.35 -0.36 9.26e-10 Gut microbiome composition (summer); CESC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg17971929 chr21:40555470 PSMG1 1.0 13.79 0.65 5.43e-33 Cognitive function; CESC cis rs6456156 0.586 rs9457261 chr6:167467679 A/G cg23791538 chr6:167370224 RNASET2 -0.5 -6.47 -0.37 4.66e-10 Primary biliary cholangitis; CESC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg00106254 chr7:1943704 MAD1L1 -0.5 -6.29 -0.36 1.32e-9 Bipolar disorder and schizophrenia; CESC cis rs11249608 0.548 rs10516150 chr5:178459169 G/C cg21905437 chr5:178450457 ZNF879 0.58 8.09 0.45 2.16e-14 Pubertal anthropometrics; CESC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg05890377 chr2:74357713 NA 0.78 10.7 0.55 1.9e-22 Gestational age at birth (maternal effect); CESC cis rs11792861 0.926 rs72607170 chr9:111836941 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 5.18 0.3 4.44e-7 Menarche (age at onset); CESC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.37 -5.36 -0.31 1.81e-7 Total body bone mineral density; CESC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg21285383 chr16:89894308 SPIRE2 0.32 5.72 0.33 2.8e-8 Vitiligo; CESC cis rs397969 0.596 rs62066350 chr17:19900042 T/C cg12073167 chr17:19770448 ULK2 -0.47 -5.34 -0.31 2.04e-7 Platelet count; CESC cis rs2797160 0.547 rs4144549 chr6:125945251 C/G cg05901451 chr6:126070800 HEY2 0.39 5.3 0.31 2.4e-7 Endometrial cancer; CESC cis rs2637266 0.783 rs10824437 chr10:78469493 C/T cg18941641 chr10:78392320 NA 0.43 8.19 0.45 1.08e-14 Pulmonary function; CESC trans rs7980799 0.716 rs1601008 chr12:33611352 A/G cg26384229 chr12:38710491 ALG10B -0.53 -7.65 -0.43 3.76e-13 Heart rate;Heart rate variability traits (RMSSD); CESC cis rs1178968 1.000 rs4717751 chr7:72750627 G/A cg25889504 chr7:72793014 NA 0.47 5.05 0.3 8.36e-7 Triglyceride levels; CESC cis rs9914988 0.943 rs9908881 chr17:27100924 T/A cg20469991 chr17:27169893 C17orf63 -0.48 -5.25 -0.31 3.18e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs7592578 0.771 rs10432434 chr2:191387079 T/G cg27211696 chr2:191398769 TMEM194B -0.62 -5.64 -0.33 4.26e-8 Diastolic blood pressure; CESC cis rs7561273 0.586 rs11892283 chr2:24317850 T/C cg20701182 chr2:24300061 SF3B14 0.52 6.63 0.38 1.89e-10 Quantitative traits; CESC cis rs6460942 0.630 rs62448731 chr7:12341174 G/A cg06484146 chr7:12443880 VWDE -0.62 -6.8 -0.39 6.82e-11 Coronary artery disease; CESC cis rs879620 1.000 rs2531995 chr16:4013467 C/T cg05927578 chr16:4029543 ADCY9 0.38 5.29 0.31 2.52e-7 Hip circumference;Body mass index; CESC cis rs832540 1.000 rs192249 chr5:56197514 C/G cg12311346 chr5:56204834 C5orf35 -0.41 -5.18 -0.3 4.42e-7 Coronary artery disease; CESC cis rs1580019 0.713 rs2167274 chr7:32524844 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.01 16.42 0.71 2.93e-42 Cognitive ability; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08536481 chr12:123459152 ABCB9;OGFOD2 -0.4 -6.14 -0.35 2.97e-9 Gambling; CESC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.57 7.79 0.43 1.55e-13 Electroencephalogram traits; CESC cis rs34779708 0.897 rs12830 chr10:35302705 C/T cg03585969 chr10:35415529 CREM 0.76 9.89 0.52 7.97e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06792154 chr17:29157990 ATAD5 -0.61 -6.85 -0.39 5.13e-11 Gut microbiome composition (summer); CESC cis rs959260 1.000 rs2385264 chr17:73364992 C/T cg12999837 chr17:73267436 MIF4GD -0.47 -5.46 -0.32 1.1e-7 Systemic lupus erythematosus; CESC cis rs3820068 0.705 rs11583306 chr1:15860803 A/G cg18192808 chr1:15853278 DNAJC16 -0.46 -5.46 -0.32 1.11e-7 Systolic blood pressure; CESC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg11663144 chr21:46675770 NA -0.5 -6.97 -0.39 2.45e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27409770 chr7:43965942 URGCP;UBE2D4 0.55 6.23 0.36 1.81e-9 Gut microbiome composition (summer); CESC cis rs3806843 0.838 rs2563289 chr5:140122766 T/A cg26395211 chr5:140044315 WDR55 0.4 5.12 0.3 5.82e-7 Depressive symptoms (multi-trait analysis); CESC cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg05340658 chr4:99064831 C4orf37 0.71 10.47 0.54 1.1e-21 Colonoscopy-negative controls vs population controls; CESC cis rs35146811 0.844 rs34031156 chr7:99677917 T/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.44 5.73 0.33 2.69e-8 Coronary artery disease; CESC cis rs7131987 0.868 rs10771508 chr12:29414211 G/A cg09582351 chr12:29534625 ERGIC2 -0.35 -5.72 -0.33 2.9e-8 QT interval; CESC cis rs2243480 1.000 rs10807701 chr7:65724686 C/A cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs56104184 0.775 rs73061697 chr19:49400000 C/T cg15549821 chr19:49342101 PLEKHA4 -0.6 -5.99 -0.35 6.95e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CESC cis rs1372520 0.748 rs1471484 chr4:90754313 C/T cg15133208 chr4:90757351 SNCA -0.42 -5.58 -0.32 6.08e-8 Neuroticism; CESC cis rs8053891 0.708 rs8055242 chr16:72006882 C/T cg04254540 chr16:71951199 KIAA0174 -0.47 -5.5 -0.32 9.16e-8 Coronary artery disease; CESC cis rs2276314 0.947 rs4799831 chr18:33554775 A/G cg19628046 chr18:33552617 C18orf21 0.55 6.0 0.35 6.59e-9 Endometriosis;Drug-induced torsades de pointes; CESC cis rs7824557 0.564 rs2572399 chr8:11234520 A/G cg21775007 chr8:11205619 TDH -0.54 -8.11 -0.45 1.87e-14 Retinal vascular caliber; CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg12262378 chr17:6899522 ALOX12 -0.41 -7.0 -0.4 2.09e-11 Tonsillectomy; CESC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg00166722 chr3:10149974 C3orf24 0.48 6.05 0.35 4.88e-9 Alzheimer's disease; CESC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg18099408 chr3:52552593 STAB1 -0.3 -5.12 -0.3 5.79e-7 Bipolar disorder; CESC cis rs7107174 1.000 rs2511180 chr11:77937255 A/G cg02023728 chr11:77925099 USP35 0.47 6.57 0.37 2.67e-10 Testicular germ cell tumor; CESC cis rs1707322 1.000 rs6672115 chr1:46272879 T/C cg06784218 chr1:46089804 CCDC17 0.36 6.04 0.35 5.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg09263875 chr16:632152 PIGQ 0.69 12.02 0.59 7.31e-27 Height; CESC cis rs10751667 0.600 rs7950955 chr11:1011490 G/A cg20946044 chr11:1010712 AP2A2 -0.48 -6.24 -0.36 1.73e-9 Alzheimer's disease (late onset); CESC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.16 0.4 7.99e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg00745463 chr17:30367425 LRRC37B -0.88 -7.7 -0.43 2.74e-13 Hip circumference adjusted for BMI; CESC cis rs17376456 0.877 rs10072592 chr5:93405989 C/G cg25358565 chr5:93447407 FAM172A 1.16 10.8 0.55 8.82e-23 Diabetic retinopathy; CESC cis rs6964587 1.000 rs28584017 chr7:91719168 G/A cg17063962 chr7:91808500 NA 0.57 7.99 0.44 4.23e-14 Breast cancer; CESC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg21782813 chr7:2030301 MAD1L1 0.43 6.1 0.35 3.77e-9 Schizophrenia; CESC trans rs16845107 0.826 rs16861032 chr3:113187675 C/G cg02899788 chr1:47133675 ATPAF1 -0.83 -6.17 -0.35 2.52e-9 Colorectal cancer; CESC cis rs2832191 0.671 rs2832213 chr21:30512914 A/G cg08807101 chr21:30365312 RNF160 -0.53 -6.27 -0.36 1.42e-9 Dental caries; CESC cis rs6500395 0.775 rs4471681 chr16:48665946 C/T cg04672837 chr16:48644449 N4BP1 0.49 6.27 0.36 1.46e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs10754283 0.967 rs7513928 chr1:90104834 A/G cg21401794 chr1:90099060 LRRC8C 0.7 9.42 0.5 2.27e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs1499614 0.803 rs1796229 chr7:66119661 G/A cg08632164 chr7:65971372 NA -0.49 -5.12 -0.3 5.92e-7 Gout; CESC cis rs367943 0.608 rs2972662 chr5:112990330 C/T cg12552261 chr5:112820674 MCC -0.4 -5.17 -0.3 4.58e-7 Type 2 diabetes; CESC cis rs2197308 0.765 rs12824529 chr12:37931656 T/C cg26384229 chr12:38710491 ALG10B 0.75 11.19 0.57 4.49e-24 Morning vs. evening chronotype; CESC cis rs12249377 0.519 rs11597471 chr10:92598767 C/G cg14313238 chr10:92632228 RPP30 0.45 5.43 0.32 1.28e-7 White matter microstructure (global fractional anisotropy); CESC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg11764359 chr7:65958608 NA -0.91 -13.88 -0.65 2.71e-33 Aortic root size; CESC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.71 11.44 0.57 6.98e-25 Personality dimensions; CESC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 1.02 11.36 0.57 1.23e-24 Platelet count; CESC cis rs12791968 0.917 rs11038239 chr11:45002012 A/G cg11846598 chr11:44996168 LOC221122 -0.56 -7.44 -0.42 1.37e-12 Inhibitory control; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg03117819 chr17:48610072 EPN3 0.46 6.05 0.35 4.79e-9 Systemic lupus erythematosus; CESC cis rs854765 0.583 rs7214536 chr17:17852446 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 8.26 0.45 7.24e-15 Total body bone mineral density; CESC cis rs4979906 1.000 rs2395494 chr10:79458340 C/T cg00983440 chr10:79422392 NA -0.44 -5.09 -0.3 6.92e-7 Mortality in heart failure; CESC cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg05340658 chr4:99064831 C4orf37 0.8 12.4 0.61 3.76e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7927592 0.731 rs2840367 chr11:68302101 G/A cg01657329 chr11:68192670 LRP5 0.49 6.51 0.37 3.72e-10 Total body bone mineral density; CESC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.17 -0.3 4.51e-7 Life satisfaction; CESC cis rs9287719 0.967 rs10454738 chr2:10742049 G/A cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs34779708 0.931 rs11593858 chr10:35381373 G/A cg04310649 chr10:35416472 CREM -0.51 -6.06 -0.35 4.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.05 0.4 1.53e-11 Bipolar disorder; CESC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.61 8.64 0.47 5.45e-16 Bipolar disorder; CESC cis rs11250464 1.000 rs11250464 chr10:1406364 A/G cg08668359 chr10:1443807 ADARB2 0.56 6.88 0.39 4.31e-11 Radiation response; CESC cis rs3733585 0.673 rs4459990 chr4:9954005 T/C cg02734326 chr4:10020555 SLC2A9 -0.39 -5.64 -0.33 4.45e-8 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11249608 0.548 rs17078988 chr5:178459283 A/G cg01312482 chr5:178451176 ZNF879 -0.45 -6.09 -0.35 4.02e-9 Pubertal anthropometrics; CESC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg21724239 chr8:58056113 NA 0.64 5.91 0.34 1.05e-8 Developmental language disorder (linguistic errors); CESC cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg25358565 chr5:93447407 FAM172A -1.01 -9.89 -0.52 7.81e-20 Diabetic retinopathy; CESC cis rs643506 0.874 rs609007 chr11:111719593 A/G cg17089665 chr11:111648010 NA 0.35 5.06 0.3 7.7300000000000005e-07 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23893906 chr12:6798535 ZNF384 0.67 7.99 0.44 4.26e-14 Gut microbiome composition (summer); CESC cis rs9814567 0.896 rs7642266 chr3:134346025 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.42 -5.67 -0.33 3.63e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7615952 0.733 rs13314847 chr3:125644788 C/T cg05084668 chr3:125655381 ALG1L -0.51 -6.1 -0.35 3.68e-9 Blood pressure (smoking interaction); CESC cis rs57024841 0.500 rs10116414 chr9:139831696 C/T cg00693599 chr9:139836323 FBXW5 0.43 6.37 0.36 8.31e-10 Beta-trace protein levels; CESC cis rs11640734 0.609 rs11647746 chr16:89806343 C/A cg06558623 chr16:89946397 TCF25 0.81 7.38 0.41 1.99e-12 Interleukin-17 levels; CESC cis rs7520050 0.807 rs6671802 chr1:46124663 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.95 0.34 8.25e-9 Red blood cell count;Reticulocyte count; CESC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg04772025 chr11:68637568 NA 0.49 5.63 0.33 4.7e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC trans rs1887596 0.624 rs9553854 chr13:27131270 T/C cg19523213 chr12:21927973 KCNJ8 0.38 6.25 0.36 1.64e-9 Facial morphology (factor 3, length of philtrum); CESC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.94 14.0 0.65 1.02e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs9400271 0.632 rs9398192 chr6:109587236 C/T cg01475377 chr6:109611718 NA -0.46 -7.18 -0.4 7.24e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CESC cis rs1538970 0.924 rs12046816 chr1:45891543 G/T cg06784218 chr1:46089804 CCDC17 0.33 5.46 0.32 1.11e-7 Platelet count; CESC cis rs9611565 0.681 rs132918 chr22:41808350 C/T cg17376030 chr22:41985996 PMM1 -0.52 -5.71 -0.33 3e-8 Vitiligo; CESC cis rs4660261 0.526 rs803680 chr1:44364370 G/C cg13606994 chr1:44402422 ARTN -0.36 -5.59 -0.32 5.53e-8 Intelligence (multi-trait analysis); CESC cis rs2777491 1.000 rs2777491 chr15:41735710 T/G cg18705301 chr15:41695430 NDUFAF1 -0.65 -9.98 -0.52 4.09e-20 Ulcerative colitis; CESC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.38 0.37 7.74e-10 Bipolar disorder; CESC cis rs9512730 0.553 rs1040986 chr13:28051352 G/T cg08193333 chr13:27998609 GTF3A 0.46 5.55 0.32 7.01e-8 Schizophrenia; CESC cis rs8177253 0.514 rs6790668 chr3:133442481 T/A cg24879335 chr3:133465180 TF 0.36 6.71 0.38 1.16e-10 Iron status biomarkers; CESC cis rs8141529 0.702 rs469991 chr22:29307859 G/C cg15103426 chr22:29168792 CCDC117 -0.6 -7.7 -0.43 2.68e-13 Lymphocyte counts; CESC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg05564831 chr3:52568323 NT5DC2 0.44 6.31 0.36 1.18e-9 Bipolar disorder; CESC cis rs4911259 0.513 rs4287835 chr20:31457337 T/C cg13636640 chr20:31349939 DNMT3B -0.58 -8.08 -0.44 2.26e-14 Inflammatory bowel disease; CESC cis rs3087591 0.919 rs2953004 chr17:29502723 C/T cg24425628 chr17:29625626 OMG;NF1 0.45 5.21 0.3 3.86e-7 Hip circumference; CESC trans rs9858542 0.953 rs34588335 chr3:49407660 G/C cg21659725 chr3:3221576 CRBN -0.55 -6.52 -0.37 3.62e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs4604732 0.527 rs7539082 chr1:247627260 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.46 0.32 1.09e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs9916302 0.706 rs903507 chr17:37726423 A/G cg07936489 chr17:37558343 FBXL20 -0.99 -11.58 -0.58 2.33e-25 Glomerular filtration rate (creatinine); CESC cis rs3733585 0.699 rs10001964 chr4:9959275 C/T cg02734326 chr4:10020555 SLC2A9 -0.44 -6.15 -0.35 2.85e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg25985355 chr7:65971099 NA 0.32 5.3 0.31 2.42e-7 Aortic root size; CESC cis rs10861342 1.000 rs1345095 chr12:105471577 C/T cg23923672 chr12:105501055 KIAA1033 0.69 5.09 0.3 6.84e-7 IgG glycosylation; CESC cis rs1707322 0.721 rs10890337 chr1:46124527 C/T cg06784218 chr1:46089804 CCDC17 0.43 7.48 0.42 1.07e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.3 -0.31 2.42e-7 Lung cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18467133 chr12:100661475 SCYL2;DEPDC4 0.59 6.4 0.37 7.02e-10 Gut microbiome composition (summer); CESC cis rs4727027 0.868 rs10952799 chr7:148840772 C/T cg23583168 chr7:148888333 NA -0.78 -12.14 -0.6 2.85e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs7267979 0.934 rs2261753 chr20:25262291 G/A cg08601574 chr20:25228251 PYGB 0.39 5.65 0.33 4.14e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs4308124 0.708 rs56693625 chr2:111965155 G/A cg04571233 chr2:111982156 NA -0.63 -6.91 -0.39 3.58e-11 Vitiligo; CESC cis rs5753618 0.583 rs5753628 chr22:31860322 A/G cg13145458 chr22:31556086 RNF185 -0.49 -5.81 -0.34 1.81e-8 Colorectal cancer; CESC cis rs10779751 0.770 rs12041740 chr1:11236524 G/A cg08854313 chr1:11322531 MTOR 0.85 12.69 0.61 3.87e-29 Body mass index; CESC cis rs2235642 0.859 rs12599207 chr16:1606445 A/G cg03715980 chr16:1756201 MAPK8IP3 0.39 5.1 0.3 6.46e-7 Coronary artery disease; CESC cis rs2404602 0.622 rs11632365 chr15:77139080 G/A cg06336613 chr15:77223807 RCN2 0.42 5.12 0.3 5.79e-7 Blood metabolite levels; CESC cis rs734999 0.545 rs7368105 chr1:2556548 C/T cg20673091 chr1:2541236 MMEL1 0.47 7.84 0.43 1.11e-13 Ulcerative colitis; CESC cis rs5750830 0.620 rs1007337 chr22:39781585 C/T cg02038168 chr22:39784481 NA -0.58 -7.73 -0.43 2.19e-13 Intelligence (multi-trait analysis); CESC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.1 21.26 0.79 3.33e-59 Prudent dietary pattern; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08730051 chr6:4018948 NA -0.48 -6.21 -0.36 2.05e-9 Fibrinogen levels; CESC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9303542 0.559 rs12939811 chr17:46607958 A/T cg04904318 chr17:46607828 HOXB1 -0.62 -6.01 -0.35 6.02e-9 Ovarian cancer;Epithelial ovarian cancer; CESC cis rs9549367 0.826 rs9549713 chr13:113905308 G/T cg18105134 chr13:113819100 PROZ -0.68 -8.25 -0.45 7.53e-15 Platelet distribution width; CESC trans rs61931739 0.534 rs11053029 chr12:34131766 G/T cg26384229 chr12:38710491 ALG10B 0.6 8.37 0.46 3.38e-15 Morning vs. evening chronotype; CESC cis rs78456975 0.739 rs72776248 chr2:1521314 A/G cg26248373 chr2:1572462 NA -0.57 -5.07 -0.3 7.51e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs4704187 0.687 rs1477933 chr5:74437153 G/A cg03227963 chr5:74354835 NA 0.3 5.58 0.32 5.99e-8 Response to amphetamines; CESC cis rs1801251 1.000 rs11555646 chr2:233599904 A/C cg25237894 chr2:233734115 C2orf82 0.47 8.13 0.45 1.66e-14 Coronary artery disease; CESC cis rs34779708 0.966 rs35777088 chr10:35409048 T/C cg04310649 chr10:35416472 CREM -0.52 -6.25 -0.36 1.62e-9 Inflammatory bowel disease;Crohn's disease; CESC cis rs763121 0.853 rs4821798 chr22:39021165 T/C cg21395723 chr22:39101663 GTPBP1 0.5 6.63 0.38 1.83e-10 Menopause (age at onset); CESC cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg16339924 chr4:17578868 LAP3 0.65 8.27 0.45 6.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs8177179 0.967 rs4994581 chr3:133437563 T/C cg17775713 chr3:133465469 TF 0.31 5.46 0.32 1.07e-7 Iron status biomarkers (transferrin levels); CESC trans rs875971 0.895 rs7788984 chr7:65915616 A/G cg26939375 chr7:64535504 NA 0.47 6.11 0.35 3.62e-9 Aortic root size; CESC cis rs9911578 0.835 rs3744093 chr17:56492800 T/C cg05425664 chr17:57184151 TRIM37 0.46 6.38 0.36 7.88e-10 Intelligence (multi-trait analysis); CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg10165071 chr2:217557160 IGFBP5 0.46 6.23 0.36 1.78e-9 Ulcerative colitis; CESC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs12476592 0.602 rs262477 chr2:63870959 A/C cg17519650 chr2:63277830 OTX1 -0.44 -5.1 -0.3 6.44e-7 Childhood ear infection; CESC cis rs2712184 0.873 rs1548945 chr2:217665788 T/C cg05032264 chr2:217675019 NA -0.42 -6.16 -0.35 2.66e-9 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC cis rs11098499 0.618 rs6858383 chr4:120296772 T/C cg24375607 chr4:120327624 NA 0.46 5.55 0.32 6.98e-8 Corneal astigmatism; CESC cis rs2066819 1.000 rs77447765 chr12:56690662 G/A cg26804944 chr12:56660921 COQ10A -0.85 -5.19 -0.3 4.22e-7 Psoriasis vulgaris; CESC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg13607699 chr17:42295918 UBTF 0.63 8.58 0.47 7.92e-16 Total body bone mineral density; CESC cis rs10392 0.543 rs3752290 chr20:37555116 G/C cg27552599 chr20:37590471 DHX35 0.39 5.82 0.34 1.73e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12165864 chr7:66369176 NA -0.6 -6.46 -0.37 5.05e-10 Gut microbiome composition (summer); CESC cis rs1371867 0.846 rs1788196 chr8:101290088 C/T cg11906718 chr8:101322791 RNF19A 0.46 5.91 0.34 1.03e-8 Atrioventricular conduction; CESC cis rs2839186 0.934 rs2839194 chr21:47699437 T/G cg10351095 chr21:47802916 PCNT -0.5 -6.79 -0.38 7.45e-11 Testicular germ cell tumor; CESC cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg11812906 chr14:75593930 NEK9 -0.9 -14.82 -0.67 1.35e-36 Height; CESC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg17971929 chr21:40555470 PSMG1 1.07 16.24 0.71 1.24e-41 Cognitive function; CESC cis rs2180341 0.700 rs4598100 chr6:127565314 G/A cg27446573 chr6:127587934 RNF146 0.83 11.45 0.58 6.5e-25 Breast cancer; CESC cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg16339924 chr4:17578868 LAP3 0.65 8.15 0.45 1.45e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07798295 chr16:89715839 CHMP1A 0.46 6.33 0.36 1.05e-9 Fibrinogen levels; CESC cis rs344364 0.511 rs2982433 chr16:1954508 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.5 -5.65 -0.33 4.1e-8 Glomerular filtration rate in chronic kidney disease; CESC cis rs8017423 0.967 rs4904663 chr14:90729565 G/T cg14092571 chr14:90743983 NA -0.56 -8.38 -0.46 3.07e-15 Mortality in heart failure; CESC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg14393609 chr7:65229607 NA 0.45 6.11 0.35 3.52e-9 Aortic root size; CESC cis rs889398 0.802 rs12921407 chr16:69860933 T/C cg09409435 chr16:70099608 PDXDC2 -0.42 -5.21 -0.31 3.73e-7 Body mass index; CESC cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg05234568 chr11:5960015 NA -0.55 -6.5 -0.37 3.93e-10 DNA methylation (variation); CESC cis rs58904263 1 rs58904263 chr20:30401406 A/AG cg13852791 chr20:30311386 BCL2L1 0.78 8.53 0.46 1.13e-15 Monocyte count; CESC cis rs17293817 0.562 rs11250484 chr10:1417599 G/T cg04271617 chr10:1416546 ADARB2 -0.31 -5.17 -0.3 4.58e-7 Ejection fraction in Tripanosoma cruzi seropositivity; CESC trans rs8180040 0.966 rs11130137 chr3:47578838 C/T cg09317728 chr14:101699148 NA -0.35 -6.01 -0.35 6.23e-9 Colorectal cancer; CESC cis rs11229555 0.645 rs12797488 chr11:58174653 A/T cg15696309 chr11:58395628 NA -0.42 -5.03 -0.3 9.17e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs34779708 0.931 rs4934533 chr10:35359619 A/G cg03585969 chr10:35415529 CREM 0.76 9.94 0.52 5.37e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs6430585 0.527 rs2289959 chr2:136423904 C/T cg07169764 chr2:136633963 MCM6 0.96 11.51 0.58 3.91e-25 Corneal structure; CESC cis rs6456156 0.586 rs13195158 chr6:167481392 G/A cg07741184 chr6:167504864 NA 0.37 6.38 0.36 7.99e-10 Primary biliary cholangitis; CESC cis rs113835537 0.735 rs519380 chr11:66409409 G/A cg24851651 chr11:66362959 CCS 0.52 5.86 0.34 1.37e-8 Airway imaging phenotypes; CESC cis rs501120 0.925 rs1657345 chr10:44779078 A/G cg09554077 chr10:44749378 NA 0.62 6.18 0.36 2.35e-9 Coronary artery disease;Coronary heart disease; CESC cis rs3743266 0.507 rs34092508 chr15:60722979 C/T cg22293140 chr15:60689852 ANXA2 -0.75 -7.76 -0.43 1.82e-13 Menarche (age at onset); CESC cis rs1008375 1.000 rs2315561 chr4:17679695 C/T cg02297831 chr4:17616191 MED28 0.45 5.77 0.33 2.26e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9910055 0.509 rs9916444 chr17:42313512 C/G cg13607699 chr17:42295918 UBTF 0.78 11.14 0.56 6.56e-24 Total body bone mineral density; CESC cis rs644799 1.000 rs680134 chr11:95559517 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.99 0.48 4.84e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7072216 0.727 rs10748728 chr10:100171198 C/T cg26618903 chr10:100175079 PYROXD2 -0.38 -5.79 -0.34 1.99e-8 Metabolite levels; CESC trans rs853679 0.825 rs8180562 chr6:28141460 G/A cg06606381 chr12:133084897 FBRSL1 -0.66 -6.19 -0.36 2.24e-9 Depression; CESC cis rs3736485 0.934 rs11635592 chr15:51859786 A/T cg08986416 chr15:51914746 DMXL2 -0.4 -5.12 -0.3 5.86e-7 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg24549020 chr5:56110836 MAP3K1 -0.49 -6.03 -0.35 5.63e-9 Initial pursuit acceleration; CESC cis rs8180040 0.587 rs62246398 chr3:47066203 A/C cg27129171 chr3:47204927 SETD2 -0.66 -9.84 -0.52 1.13e-19 Colorectal cancer; CESC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg08968635 chr6:28129556 ZNF389 0.39 5.22 0.31 3.64e-7 Depression; CESC cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg17366294 chr4:99064904 C4orf37 0.59 8.52 0.46 1.24e-15 Colonoscopy-negative controls vs population controls; CESC cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg08109568 chr15:31115862 NA 0.67 7.34 0.41 2.57e-12 Huntington's disease progression; CESC cis rs2415984 0.519 rs2642102 chr14:46965502 A/G cg14871534 chr14:47121158 RPL10L 0.35 5.32 0.31 2.24e-7 Number of children ever born; CESC cis rs11690935 0.959 rs1474074 chr2:172659852 G/A cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.46 -0.66 2.51e-35 Schizophrenia; CESC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg06634786 chr22:41940651 POLR3H 0.68 6.72 0.38 1.13e-10 Crohn's disease;Inflammatory bowel disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21056458 chr19:12817517 SNORD41;TNPO2 0.53 7.4 0.41 1.79e-12 Fibrinogen levels; CESC cis rs75804782 0.521 rs56121087 chr2:239435766 A/G cg18131467 chr2:239335373 ASB1 -0.68 -5.18 -0.3 4.38e-7 Morning vs. evening chronotype;Chronotype; CESC cis rs34779708 1.000 rs34779708 chr10:35466185 T/G cg03585969 chr10:35415529 CREM 0.76 10.01 0.52 3.32e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7089973 0.604 rs7914792 chr10:116591391 T/C cg03647239 chr10:116582469 FAM160B1 0.43 5.29 0.31 2.6e-7 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs2115172 0.836 rs4835799 chr5:122762229 A/G cg21939482 chr7:6388130 C7orf70 0.47 6.22 0.36 1.97e-9 Weight; CESC cis rs2933343 0.649 rs1683786 chr3:128626952 T/C cg25356066 chr3:128598488 ACAD9 0.6 8.46 0.46 1.79e-15 IgG glycosylation; CESC cis rs2439831 0.702 rs495175 chr15:43798684 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.88 12.38 0.61 4.47e-28 Lung cancer in ever smokers; CESC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg23758822 chr17:41437982 NA 1.05 16.2 0.71 1.69e-41 Menopause (age at onset); CESC cis rs1062753 0.771 rs932376 chr22:42614362 T/C cg00645731 chr22:42541494 CYP2D7P1 0.41 6.6 0.38 2.27e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC trans rs4332037 0.539 rs11764780 chr7:2020904 G/C cg11693508 chr17:37793320 STARD3 0.67 6.73 0.38 1.07e-10 Bipolar disorder; CESC cis rs17818399 0.749 rs4142759 chr2:46783890 A/G cg02822958 chr2:46747628 ATP6V1E2 0.47 5.59 0.32 5.65e-8 Height; CESC cis rs763121 0.814 rs5757212 chr22:39053757 G/C cg06544989 chr22:39130855 UNC84B 0.5 9.13 0.49 1.87e-17 Menopause (age at onset); CESC cis rs36207871 1 rs36207871 chr12:56684496 TAGGAA/T cg26734620 chr12:56694298 CS -0.93 -9.55 -0.51 9.4e-19 Inflammatory skin disease; CESC cis rs3015497 0.616 rs6572678 chr14:51090115 T/G cg09863266 chr14:51125203 SAV1 -0.32 -5.06 -0.3 7.7300000000000005e-07 Mean platelet volume; CESC cis rs11690935 1.000 rs11678984 chr2:172535848 T/G cg13550731 chr2:172543902 DYNC1I2 1.01 16.72 0.72 2.4e-43 Schizophrenia; CESC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.43 0.32 1.27e-7 Bipolar disorder; CESC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg10494973 chr17:80897199 TBCD 0.51 5.8 0.34 1.88e-8 Breast cancer; CESC cis rs7267979 1.000 rs398036 chr20:25439850 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 15.9 0.7 1.91e-40 Liver enzyme levels (alkaline phosphatase); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22164177 chr12:117013718 MAP1LC3B2 -0.6 -7.08 -0.4 1.28e-11 Gut microbiome composition (summer); CESC cis rs367943 0.799 rs13154055 chr5:112971516 A/T cg12552261 chr5:112820674 MCC 0.54 6.14 0.35 3.08e-9 Type 2 diabetes; CESC cis rs7107174 1.000 rs7117238 chr11:78040259 G/A cg02023728 chr11:77925099 USP35 0.38 5.6 0.33 5.26e-8 Testicular germ cell tumor; CESC cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg17366294 chr4:99064904 C4orf37 0.6 8.62 0.47 6.37e-16 Colonoscopy-negative controls vs population controls; CESC cis rs6499255 0.951 rs56316408 chr16:69658776 A/G cg15192750 chr16:69999425 NA 0.51 5.87 0.34 1.33e-8 IgE levels; CESC cis rs6723226 0.557 rs62136260 chr2:32575447 T/C cg02381751 chr2:32503542 YIPF4 -0.43 -5.32 -0.31 2.21e-7 Intelligence (multi-trait analysis); CESC cis rs941207 0.547 rs56183434 chr12:57069929 G/T cg05584118 chr12:57595605 LRP1 -0.38 -5.17 -0.3 4.54e-7 Platelet count; CESC cis rs2635047 0.601 rs2684842 chr18:44725289 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.32 -5.07 -0.3 7.61e-7 Educational attainment; CESC cis rs61542988 0.756 rs5013587 chr7:22882660 C/T cg13679077 chr7:22862647 TOMM7 0.61 7.47 0.42 1.18e-12 Fibrinogen levels; CESC cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg03467027 chr4:99064603 C4orf37 0.44 5.54 0.32 7.16e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7607369 0.759 rs10179708 chr2:219390967 T/A cg02176678 chr2:219576539 TTLL4 -0.54 -9.8 -0.52 1.49e-19 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs8141529 0.732 rs6005872 chr22:29172898 T/G cg02153584 chr22:29168773 CCDC117 0.71 10.07 0.53 2.16e-20 Lymphocyte counts; CESC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 11.1 0.56 9.54e-24 Platelet count; CESC cis rs1511802 0.591 rs6810892 chr4:187123941 C/T cg24794857 chr4:187113578 CYP4V2 0.46 6.07 0.35 4.37e-9 Blood protein levels; CESC cis rs10870270 0.956 rs10870293 chr10:133771413 G/A cg17892150 chr10:133769511 PPP2R2D -0.87 -12.66 -0.61 4.87e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs763121 0.785 rs5757199 chr22:39040617 T/G cg21395723 chr22:39101663 GTPBP1 0.43 5.33 0.31 2.09e-7 Menopause (age at onset); CESC cis rs151234 0.741 rs11647881 chr16:28606173 C/A cg01378222 chr16:28622494 SULT1A1 -0.55 -6.5 -0.37 4.03e-10 Platelet distribution width; CESC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg19346786 chr7:2764209 NA -0.5 -7.24 -0.41 4.86e-12 Height; CESC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg12463550 chr7:65579703 CRCP -0.51 -6.36 -0.36 8.66e-10 Aortic root size; CESC cis rs6060717 0.610 rs1891154 chr20:34617129 T/G cg23207816 chr20:34252616 CPNE1;RBM12 0.49 6.22 0.36 1.96e-9 Hip circumference adjusted for BMI; CESC cis rs8005677 0.962 rs10130756 chr14:23396600 C/G cg25600027 chr14:23388339 RBM23 -0.44 -5.37 -0.31 1.69e-7 Cognitive ability (multi-trait analysis); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg22190090 chr17:36955626 PIP4K2B 0.48 6.12 0.35 3.44e-9 Gut microbiota (bacterial taxa); CESC cis rs9916302 0.904 rs2338797 chr17:37548241 G/A cg20243544 chr17:37824526 PNMT -0.51 -6.5 -0.37 4.07e-10 Glomerular filtration rate (creatinine); CESC cis rs12464559 0.649 rs4306714 chr2:152611351 G/A cg01189475 chr2:152685088 ARL5A 0.66 5.57 0.32 6.14e-8 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg27028030 chr7:100209634 MOSPD3 0.57 5.59 0.32 5.72e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs854765 0.547 rs7224047 chr17:17932931 G/A cg09796270 chr17:17721594 SREBF1 0.37 5.08 0.3 7.17e-7 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16437679 chr6:146056419 EPM2A 0.54 6.07 0.35 4.33e-9 Gut microbiome composition (summer); CESC cis rs4132509 0.948 rs7517921 chr1:243856420 T/C cg21452805 chr1:244014465 NA 0.42 5.03 0.3 9.13e-7 RR interval (heart rate); CESC cis rs7247513 0.790 rs8112964 chr19:12752173 C/T cg11738485 chr19:12877000 HOOK2 0.46 5.56 0.32 6.48e-8 Bipolar disorder; CESC cis rs1044573 0.526 rs6050422 chr20:25177920 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.5 7.5 0.42 9.9e-13 Allergic rhinitis; CESC cis rs78132593 0.723 rs34593358 chr1:150686633 A/T cg04414720 chr1:150670196 GOLPH3L -0.51 -6.01 -0.35 6.17e-9 High light scatter reticulocyte count; CESC cis rs12477438 0.765 rs6750876 chr2:99679673 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC trans rs116095464 0.867 rs7726582 chr5:215349 C/G cg00938859 chr5:1591904 SDHAP3 0.62 6.81 0.39 6.42e-11 Breast cancer; CESC cis rs9291683 0.588 rs3756238 chr4:10013202 C/T cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.7e-37 Bone mineral density; CESC trans rs9325144 0.600 rs12297194 chr12:38735803 A/G cg23762105 chr12:34175262 ALG10 0.45 6.12 0.35 3.32e-9 Morning vs. evening chronotype; CESC cis rs909002 0.849 rs6663012 chr1:32091779 T/G cg13919466 chr1:32135498 COL16A1 -0.46 -8.18 -0.45 1.21e-14 Intelligence (multi-trait analysis); CESC cis rs6582630 0.537 rs8189533 chr12:38391068 A/G cg13010199 chr12:38710504 ALG10B 0.54 6.67 0.38 1.45e-10 Drug-induced liver injury (flucloxacillin); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg24744501 chr2:207024175 NDUFS1;EEF1B2 -0.5 -6.73 -0.38 1.06e-10 Fibrinogen levels; CESC cis rs7100689 0.784 rs17678947 chr10:82136333 T/C cg00277334 chr10:82204260 NA -0.58 -7.29 -0.41 3.66e-12 Post bronchodilator FEV1; CESC cis rs2072732 0.656 rs113272167 chr1:2954051 C/T cg03976712 chr1:2946727 NA 0.34 5.63 0.33 4.57e-8 Plateletcrit; CESC cis rs709400 0.770 rs7142883 chr14:104066645 G/A cg24130564 chr14:104152367 KLC1 -0.43 -5.19 -0.3 4.27e-7 Body mass index; CESC cis rs6121246 0.560 rs6088854 chr20:30225357 G/A cg13852791 chr20:30311386 BCL2L1 0.76 6.19 0.36 2.26e-9 Mean corpuscular hemoglobin; CESC cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg10556349 chr10:835070 NA 0.62 5.91 0.34 1.05e-8 Eosinophil percentage of granulocytes; CESC cis rs34779708 0.733 rs4934740 chr10:35547141 C/T cg03585969 chr10:35415529 CREM 0.55 6.37 0.36 8.28e-10 Inflammatory bowel disease;Crohn's disease; CESC cis rs7179456 0.545 rs507801 chr15:59053345 T/G cg05156742 chr15:59063176 FAM63B 0.58 7.11 0.4 1.09e-11 Asperger disorder; CESC cis rs116095464 0.510 rs60844864 chr5:267000 A/G cg10591111 chr5:226296 SDHA -0.52 -6.16 -0.35 2.62e-9 Breast cancer; CESC cis rs4148883 0.689 rs2602861 chr4:100030896 C/T cg12011299 chr4:100065546 ADH4 0.69 10.44 0.54 1.38e-21 Alcohol dependence; CESC cis rs10504229 0.531 rs55923836 chr8:57999127 A/G cg22535103 chr8:58192502 C8orf71 -0.56 -6.58 -0.37 2.48e-10 Developmental language disorder (linguistic errors); CESC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg18032046 chr6:28092343 ZSCAN16 -0.6 -6.84 -0.39 5.51e-11 Parkinson's disease; CESC trans rs561341 1.000 rs561341 chr17:30316385 T/G cg27661571 chr11:113659931 NA -0.83 -7.76 -0.43 1.9e-13 Hip circumference adjusted for BMI; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19575883 chr2:172231724 METTL8 0.46 6.27 0.36 1.45e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04322344 chr3:131221642 MRPL3 -0.43 -6.3 -0.36 1.26e-9 Gambling; CESC cis rs703842 1.000 rs10783848 chr12:58196528 G/A cg00599273 chr12:58146742 CDK4 0.33 5.06 0.3 7.92e-7 Multiple sclerosis; CESC cis rs2710642 0.564 rs7583570 chr2:62852926 C/T cg17519650 chr2:63277830 OTX1 0.49 6.54 0.37 3.2e-10 LDL cholesterol levels;LDL cholesterol; CESC trans rs11098499 0.909 rs10002083 chr4:120311152 C/T cg25214090 chr10:38739885 LOC399744 0.68 9.2 0.49 1.14e-17 Corneal astigmatism; CESC cis rs7107174 0.892 rs4944196 chr11:78008731 G/A cg02023728 chr11:77925099 USP35 0.5 6.69 0.38 1.33e-10 Testicular germ cell tumor; CESC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg00149659 chr3:10157352 C3orf10 0.71 8.63 0.47 5.76e-16 Alzheimer's disease; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg17338258 chr17:7533521 SHBG -0.45 -6.38 -0.36 7.93e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs919433 1.000 rs6741380 chr2:198165121 A/G cg03934865 chr2:198174659 NA 0.41 6.1 0.35 3.72e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs4727027 0.933 rs12704063 chr7:148827909 T/C cg23158103 chr7:148848205 ZNF398 -0.41 -6.74 -0.38 9.65e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs1878931 0.545 rs28603 chr16:3449479 A/G cg21433313 chr16:3507492 NAT15 0.39 5.05 0.3 8.36e-7 Body mass index (adult); CESC trans rs11098499 0.863 rs9997631 chr4:120469995 C/G cg25214090 chr10:38739885 LOC399744 0.68 9.39 0.5 2.82e-18 Corneal astigmatism; CESC cis rs7178572 1.000 rs62007299 chr15:77711719 G/A cg22256960 chr15:77711686 NA -0.58 -7.92 -0.44 6.36e-14 Type 2 diabetes; CESC cis rs10129255 0.500 rs8014529 chr14:107192302 G/A cg07958169 chr14:107095056 NA -0.54 -8.32 -0.45 4.77e-15 Kawasaki disease; CESC cis rs7312933 0.533 rs3747557 chr12:42717961 G/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.4 -0.37 7.07e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs13720 0.722 rs163791 chr20:57576174 G/A cg23907860 chr20:57583709 CTSZ -0.48 -5.92 -0.34 1.01e-8 Platelet distribution width; CESC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg25036284 chr2:26402008 FAM59B -0.73 -8.24 -0.45 8.07e-15 Gut microbiome composition (summer); CESC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg04267008 chr7:1944627 MAD1L1 -0.65 -7.93 -0.44 5.95e-14 Bipolar disorder and schizophrenia; CESC cis rs3806843 0.735 rs801185 chr5:140068869 A/G cg26395211 chr5:140044315 WDR55 0.47 6.03 0.35 5.51e-9 Depressive symptoms (multi-trait analysis); CESC cis rs9487051 0.676 rs13195816 chr6:109598624 T/C cg12927641 chr6:109611667 NA -0.37 -5.54 -0.32 7.26e-8 Reticulocyte fraction of red cells; CESC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg18490616 chr2:88469792 THNSL2 -0.44 -6.45 -0.37 5.22e-10 Response to metformin (IC50); CESC cis rs9858542 0.903 rs11921590 chr3:49644193 T/C cg07274523 chr3:49395745 GPX1 0.68 8.71 0.47 3.38e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs734999 0.588 rs2764842 chr1:2529192 A/G cg20673091 chr1:2541236 MMEL1 -0.44 -7.23 -0.41 5.08e-12 Ulcerative colitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21768436 chr8:67341108 RRS1 0.59 6.36 0.36 8.96e-10 Gut microbiome composition (summer); CESC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg22920501 chr2:26401640 FAM59B -0.67 -8.22 -0.45 9.42e-15 Gut microbiome composition (summer); CESC cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg22875332 chr1:76189707 ACADM 0.61 6.25 0.36 1.68e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3796352 0.764 rs11714902 chr3:53101544 G/C cg15956490 chr3:53032818 SFMBT1 0.63 5.21 0.3 3.88e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs79976124 0.797 rs77895756 chr6:66626782 C/T cg07460842 chr6:66804631 NA 0.74 8.58 0.47 7.85e-16 Type 2 diabetes; CESC trans rs7618501 1.000 rs9872864 chr3:49792023 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -8.5 -0.46 1.38e-15 Intelligence (multi-trait analysis); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03734322 chr17:1532856 SLC43A2 -0.46 -6.81 -0.39 6.64e-11 Gambling; CESC cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.75 7.24 0.41 4.83e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs3820068 0.553 rs7545782 chr1:15955227 G/C cg16988262 chr1:15930761 NA 0.34 5.43 0.32 1.24e-7 Systolic blood pressure; CESC cis rs2404602 0.536 rs7165025 chr15:76766434 G/A cg26408565 chr15:76604113 ETFA -0.43 -6.43 -0.37 5.98e-10 Blood metabolite levels; CESC cis rs7000551 0.715 rs2461478 chr8:22378236 A/G cg12081754 chr8:22256438 SLC39A14 0.42 5.61 0.33 5.13e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs9926296 0.533 rs12102297 chr16:89812762 C/A cg21285383 chr16:89894308 SPIRE2 0.3 5.39 0.31 1.55e-7 Vitiligo; CESC cis rs1729951 0.546 rs835634 chr3:136676303 C/T cg04103450 chr3:136751342 NA 0.39 5.15 0.3 5.14e-7 Neuroticism; CESC cis rs12220238 1.000 rs10824099 chr10:75943625 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.61 5.42 0.32 1.34e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs867529 0.695 rs335115 chr2:89027647 C/T cg26627705 chr2:89060884 NA 0.38 5.46 0.32 1.1e-7 Height; CESC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg17294928 chr15:75287854 SCAMP5 0.49 6.16 0.35 2.68e-9 Breast cancer; CESC cis rs9790314 1.000 rs336567 chr3:161073046 A/G cg03342759 chr3:160939853 NMD3 -0.5 -6.45 -0.37 5.33e-10 Morning vs. evening chronotype; CESC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg21770322 chr7:97807741 LMTK2 0.58 8.95 0.48 6.37e-17 Prostate cancer (SNP x SNP interaction); CESC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg18765753 chr7:1198926 ZFAND2A -0.43 -6.41 -0.37 6.62e-10 Longevity;Endometriosis; CESC cis rs10463316 0.894 rs7723379 chr5:150765025 T/C cg03212797 chr5:150827313 SLC36A1 -0.46 -6.04 -0.35 5.23e-9 Metabolite levels (Pyroglutamine); CESC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg09365446 chr1:150670422 GOLPH3L 0.41 5.76 0.33 2.36e-8 Melanoma; CESC cis rs8141529 0.702 rs469991 chr22:29307859 G/C cg02153584 chr22:29168773 CCDC117 -0.57 -7.33 -0.41 2.86e-12 Lymphocyte counts; CESC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.31 0.36 1.17e-9 Menopause (age at onset); CESC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg11941060 chr3:133502564 NA -0.49 -6.7 -0.38 1.26e-10 Iron status biomarkers; CESC cis rs9287719 0.601 rs1861299 chr2:10763757 C/G cg00105475 chr2:10696890 NA 0.37 5.03 0.3 9.03e-7 Prostate cancer; CESC cis rs1775715 0.737 rs11817598 chr10:32206259 A/G cg04359828 chr10:32216031 ARHGAP12 0.35 5.04 0.3 8.57e-7 Bipolar disorder with mood-incongruent psychosis; CESC cis rs7512552 0.839 rs698919 chr1:150387000 A/G cg15654264 chr1:150340011 RPRD2 0.4 5.3 0.31 2.4e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs9325144 0.625 rs11534879 chr12:38968165 A/G cg26384229 chr12:38710491 ALG10B -0.54 -7.65 -0.43 3.83e-13 Morning vs. evening chronotype; CESC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg05064044 chr6:292385 DUSP22 -0.68 -8.83 -0.48 1.43e-16 Menopause (age at onset); CESC cis rs12995849 0.905 rs7565757 chr2:106452408 T/A cg16077055 chr2:106428750 NCK2 0.39 6.23 0.36 1.85e-9 Addiction; CESC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg18404041 chr3:52824283 ITIH1 -0.46 -7.52 -0.42 8.75e-13 Bipolar disorder; CESC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg24060327 chr5:131705240 SLC22A5 -0.77 -10.88 -0.56 4.91e-23 Breast cancer; CESC cis rs13242816 1.000 rs17138767 chr7:116137677 A/G cg04696780 chr7:116139425 CAV2 -0.61 -5.51 -0.32 8.44e-8 P wave duration; CESC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg15782153 chr7:917662 C7orf20 0.52 5.71 0.33 3e-8 Cerebrospinal P-tau181p levels; CESC cis rs897080 0.514 rs1067376 chr2:44648361 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 5.91 0.34 1.07e-8 Height; CESC cis rs9583531 0.689 rs4773244 chr13:111383937 A/T cg15841412 chr13:111365552 ING1 -0.47 -5.76 -0.33 2.28e-8 Coronary artery disease; CESC cis rs2637266 0.756 rs846621 chr10:78545171 G/T cg18941641 chr10:78392320 NA 0.39 7.24 0.41 4.76e-12 Pulmonary function; CESC cis rs1670533 1.000 rs6599279 chr4:1058833 G/A cg27284194 chr4:1044797 NA 0.47 5.99 0.35 6.88e-9 Recombination rate (females); CESC cis rs9910055 0.615 rs189049 chr17:42197213 A/C cg10896456 chr17:42255109 ASB16;C17orf65 -0.5 -7.58 -0.42 5.97e-13 Total body bone mineral density; CESC cis rs9911578 0.730 rs55759249 chr17:57027135 A/G cg12560992 chr17:57184187 TRIM37 -0.89 -11.35 -0.57 1.38e-24 Intelligence (multi-trait analysis); CESC cis rs4803468 0.967 rs3786553 chr19:41902746 T/G cg14132834 chr19:41945861 ATP5SL -0.57 -7.1 -0.4 1.17e-11 Height; CESC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg00310523 chr12:86230176 RASSF9 0.35 5.49 0.32 9.42e-8 Major depressive disorder; CESC cis rs4148883 0.675 rs28762430 chr4:100119257 C/A cg13256891 chr4:100009986 ADH5 0.53 6.91 0.39 3.49e-11 Alcohol dependence; CESC cis rs265548 0.646 rs36692 chr19:17906839 C/T cg00024989 chr19:17902242 NA 0.43 7.57 0.42 6.33e-13 Tumor biomarkers; CESC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg09359103 chr1:154839909 KCNN3 -0.66 -12.34 -0.6 5.93e-28 Prostate cancer; CESC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.33 -0.31 2.07e-7 Developmental language disorder (linguistic errors); CESC cis rs10791097 0.694 rs7926167 chr11:130745045 T/C cg12179176 chr11:130786555 SNX19 0.64 9.86 0.52 9.69e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg25036284 chr2:26402008 FAM59B 0.86 9.36 0.5 3.44e-18 Gut microbiome composition (summer); CESC cis rs4141404 0.737 rs5998067 chr22:32043630 C/T cg02404636 chr22:31891804 SFI1 -0.37 -5.12 -0.3 5.89e-7 Paclitaxel-induced neuropathy; CESC cis rs477692 1.000 rs473771 chr10:131408155 A/C cg05714579 chr10:131428358 MGMT 0.5 6.82 0.39 6.27e-11 Response to temozolomide; CESC cis rs6570726 0.935 rs391820 chr6:145821284 C/T cg23711669 chr6:146136114 FBXO30 0.76 11.32 0.57 1.68e-24 Lobe attachment (rater-scored or self-reported); CESC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg22823121 chr1:150693482 HORMAD1 0.4 5.7 0.33 3.2e-8 Melanoma; CESC cis rs6690583 0.697 rs10873684 chr1:85522196 T/C cg11262906 chr1:85462892 MCOLN2 -0.43 -5.16 -0.3 4.86e-7 Serum sulfate level; CESC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg22823121 chr1:150693482 HORMAD1 0.48 7.12 0.4 1.03e-11 Tonsillectomy; CESC cis rs6688613 0.649 rs11584352 chr1:166850372 T/C cg07049167 chr1:166818506 POGK 0.46 5.4 0.31 1.47e-7 Refractive astigmatism; CESC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg03517284 chr6:25882590 NA -0.45 -6.4 -0.37 7.15e-10 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg16384552 chr7:74938386 SPDYE8P 0.49 6.36 0.36 8.94e-10 Fibrinogen levels; CESC cis rs7829975 0.514 rs2945873 chr8:8260445 C/T cg06636001 chr8:8085503 FLJ10661 0.53 7.03 0.4 1.79e-11 Mood instability; CESC cis rs7520050 0.931 rs11576305 chr1:46460046 C/T cg24296786 chr1:45957014 TESK2 0.45 5.65 0.33 4.17e-8 Red blood cell count;Reticulocyte count; CESC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg03576123 chr11:487126 PTDSS2 -1.12 -11.26 -0.57 2.72e-24 Body mass index; CESC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.27 0.41 4.02e-12 Bipolar disorder; CESC cis rs7312933 0.618 rs6582394 chr12:42686189 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 5.98 0.34 7.34e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs4900538 0.819 rs72700604 chr14:102882307 G/A cg18135206 chr14:102964638 TECPR2 -0.74 -9.44 -0.5 2.05e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; CESC cis rs9911578 1.000 rs304296 chr17:56834229 G/T cg05425664 chr17:57184151 TRIM37 -0.48 -6.72 -0.38 1.12e-10 Intelligence (multi-trait analysis); CESC cis rs7246865 0.510 rs1551551 chr19:17170541 G/T cg16202187 chr19:17186497 HAUS8;MYO9B 0.48 6.26 0.36 1.56e-9 Reticulocyte fraction of red cells; CESC cis rs12190007 0.547 rs3006181 chr6:169809117 T/A cg15038512 chr6:170123185 PHF10 -0.48 -6.81 -0.39 6.6e-11 Obesity-related traits; CESC cis rs9715521 0.935 rs72634625 chr4:59836434 T/A cg11281224 chr4:60001000 NA -0.51 -6.6 -0.38 2.29e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg05347473 chr6:146136440 FBXO30 0.63 8.03 0.44 3.29e-14 Lobe attachment (rater-scored or self-reported); CESC cis rs9811920 0.609 rs793463 chr3:99620252 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.64 10.11 0.53 1.53e-20 Axial length; CESC cis rs11122272 0.735 rs2790893 chr1:231508976 T/G cg06096015 chr1:231504339 EGLN1 0.44 6.32 0.36 1.08e-9 Hemoglobin concentration; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg00271154 chr2:113033418 ZC3H6 -0.5 -7.1 -0.4 1.15e-11 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg17372223 chr3:52568218 NT5DC2 0.44 6.67 0.38 1.47e-10 Intelligence (multi-trait analysis); CESC cis rs7395581 0.959 rs2279239 chr11:47281780 T/C cg25783544 chr11:47291846 MADD 0.6 7.8 0.43 1.47e-13 HDL cholesterol; CESC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg14926445 chr8:58193284 C8orf71 -0.52 -5.57 -0.32 6.33e-8 Developmental language disorder (linguistic errors); CESC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg23161317 chr6:28129485 ZNF389 0.44 5.69 0.33 3.31e-8 Depression; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06138422 chr12:133338013 ANKLE2 -0.46 -6.07 -0.35 4.47e-9 Ulcerative colitis; CESC cis rs189798 0.592 rs10111263 chr8:8969433 C/G cg15556689 chr8:8085844 FLJ10661 -0.5 -6.4 -0.37 7.16e-10 Myopia (pathological); CESC cis rs4704187 0.687 rs4361493 chr5:74405097 A/G cg03227963 chr5:74354835 NA 0.32 5.94 0.34 8.7e-9 Response to amphetamines; CESC cis rs4835473 0.932 rs1849115 chr4:144910840 A/T cg25736465 chr4:144833511 NA 0.41 6.26 0.36 1.54e-9 Immature fraction of reticulocytes; CESC cis rs453301 0.571 rs2929456 chr8:9083416 G/A cg06636001 chr8:8085503 FLJ10661 -0.55 -7.11 -0.4 1.08e-11 Joint mobility (Beighton score); CESC trans rs61931739 0.890 rs814663 chr12:34106338 C/T cg26384229 chr12:38710491 ALG10B 0.44 6.0 0.35 6.52e-9 Morning vs. evening chronotype; CESC cis rs6688613 0.685 rs10800276 chr1:166858941 A/G ch.1.3259774R chr1:166827647 TADA1 -0.57 -5.68 -0.33 3.48e-8 Refractive astigmatism; CESC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg24829409 chr8:58192753 C8orf71 -0.53 -6.73 -0.38 1.04e-10 Developmental language disorder (linguistic errors); CESC cis rs3796352 1.000 rs11713859 chr3:53042080 C/A cg12962167 chr3:53033115 SFMBT1 0.65 5.17 0.3 4.52e-7 Immune reponse to smallpox (secreted IL-2); CESC cis rs61931739 0.534 rs7302688 chr12:34235064 A/G cg19457237 chr12:34500585 NA -0.38 -5.29 -0.31 2.63e-7 Morning vs. evening chronotype; CESC cis rs9640161 0.702 rs1962004 chr7:150020381 G/A cg27494647 chr7:150038898 RARRES2 0.43 5.04 0.3 8.51e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs7020830 0.522 rs10814509 chr9:37111057 A/G cg14294708 chr9:37120828 ZCCHC7 0.82 11.6 0.58 2e-25 Schizophrenia; CESC cis rs9929218 0.954 rs1981871 chr16:68819007 C/T cg02972257 chr16:68554789 NA 0.49 5.82 0.34 1.7e-8 Colorectal cancer; CESC cis rs11048434 0.761 rs1805721 chr12:9147569 A/G cg23795048 chr12:9217529 LOC144571 -0.33 -5.04 -0.3 8.53e-7 Sjögren's syndrome; CESC cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg16339924 chr4:17578868 LAP3 0.74 9.65 0.51 4.51e-19 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6912958 0.781 rs1051148 chr6:88221892 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.12 -0.3 5.99e-7 Monocyte percentage of white cells; CESC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg05564831 chr3:52568323 NT5DC2 0.46 7.38 0.41 2.06e-12 Bipolar disorder; CESC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg07167872 chr1:205819463 PM20D1 0.85 15.13 0.68 1.07e-37 Menarche (age at onset); CESC cis rs17125944 0.505 rs28568967 chr14:53223060 A/G cg13660082 chr14:53194042 PSMC6 -0.67 -6.07 -0.35 4.39e-9 Alzheimer's disease (late onset); CESC cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg10556349 chr10:835070 NA 0.76 6.39 0.37 7.22e-10 Eosinophil percentage of granulocytes; CESC cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg03676636 chr4:99064102 C4orf37 -0.33 -5.16 -0.3 4.92e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9581857 0.579 rs77187836 chr13:27998646 C/A cg22138327 chr13:27999177 GTF3A 0.66 5.57 0.32 6.41e-8 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg18446336 chr7:2847575 GNA12 -0.39 -6.52 -0.37 3.45e-10 Height; CESC cis rs2046867 0.862 rs2322612 chr3:72830058 A/G cg25664220 chr3:72788482 NA -0.45 -6.69 -0.38 1.28e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CESC cis rs1008375 0.898 rs10008445 chr4:17593978 G/T cg27347728 chr4:17578864 LAP3 0.44 5.24 0.31 3.33e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs1707322 0.691 rs11211175 chr1:46220884 C/G cg06784218 chr1:46089804 CCDC17 0.42 7.59 0.42 5.59e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs12478296 0.786 rs55876934 chr2:243033816 C/T cg06360820 chr2:242988706 NA -0.7 -7.87 -0.44 9.07e-14 Obesity-related traits; CESC cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg05283184 chr6:79620031 NA -0.43 -6.55 -0.37 2.95e-10 Intelligence (multi-trait analysis); CESC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.72 0.38 1.1e-10 Depression; CESC cis rs1707322 1.000 rs11211243 chr1:46455433 G/C cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4523957 0.583 rs2760735 chr17:2036835 A/G cg16513277 chr17:2031491 SMG6 -0.78 -11.57 -0.58 2.42e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs96067 0.805 rs1033890 chr1:36608414 C/T cg24686825 chr1:36642396 MAP7D1 -0.51 -5.49 -0.32 9.31e-8 Corneal structure; CESC cis rs6500602 0.564 rs3747584 chr16:4516092 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.41 5.73 0.33 2.72e-8 Schizophrenia; CESC cis rs10129255 1.000 rs10129255 chr14:107176213 A/G cg23076370 chr14:107095027 NA 0.43 5.18 0.3 4.41e-7 Kawasaki disease; CESC cis rs6977660 0.507 rs72591450 chr7:19775480 A/G cg05791153 chr7:19748676 TWISTNB 0.75 6.76 0.38 8.75e-11 Thyroid stimulating hormone; CESC cis rs7071206 0.853 rs114936111 chr10:79430143 G/A cg00983440 chr10:79422392 NA -0.61 -7.67 -0.43 3.27e-13 Bone mineral density; CESC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.42e-7 Life satisfaction; CESC trans rs9354352 0.935 rs7766730 chr6:66697003 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 9.93 0.52 5.77e-20 Initial pursuit acceleration in psychotic disorders; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23329543 chr19:53432372 ZNF321 -0.46 -6.67 -0.38 1.51e-10 Asthma; CESC cis rs7833790 0.553 rs9693128 chr8:82706128 A/G cg23324259 chr8:82754387 SNX16 -0.43 -5.49 -0.32 9.36e-8 Diastolic blood pressure; CESC cis rs72781680 1.000 rs72796389 chr2:24171761 A/G cg08917208 chr2:24149416 ATAD2B 0.94 8.58 0.47 7.87e-16 Lymphocyte counts; CESC cis rs4835473 0.863 rs13146607 chr4:144608436 C/T cg25736465 chr4:144833511 NA -0.4 -5.77 -0.33 2.17e-8 Immature fraction of reticulocytes; CESC cis rs13102973 0.965 rs4640720 chr4:135850050 G/T cg14419869 chr4:135874104 NA 0.33 5.19 0.3 4.29e-7 Subjective well-being; CESC cis rs6754311 0.593 rs10186843 chr2:136586958 C/A cg07169764 chr2:136633963 MCM6 -0.68 -8.29 -0.45 5.57e-15 Mosquito bite size; CESC cis rs7829975 0.714 rs60315134 chr8:8670599 A/G cg17143192 chr8:8559678 CLDN23 0.42 5.24 0.31 3.28e-7 Mood instability; CESC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg01448562 chr3:133502909 NA 0.51 7.29 0.41 3.66e-12 Iron status biomarkers; CESC cis rs916888 0.773 rs199533 chr17:44828931 G/A cg01570182 chr17:44337453 NA 0.91 10.63 0.55 3.34e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3845702 0.733 rs12693217 chr2:180841914 T/G cg01881094 chr2:180872142 CWC22 -1.06 -9.19 -0.49 1.18e-17 Schizophrenia; CESC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg11890956 chr21:40555474 PSMG1 1.18 21.96 0.8 1.36e-61 Cognitive function; CESC cis rs1178968 1.000 rs3108462 chr7:72739455 T/C cg25889504 chr7:72793014 NA 0.47 5.03 0.3 8.91e-7 Triglyceride levels; CESC trans rs2965280 0.793 rs111921454 chr19:34819296 C/T cg05799317 chr6:165723796 C6orf118 0.81 6.0 0.35 6.45e-9 Colorectal cancer; CESC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg18099408 chr3:52552593 STAB1 0.33 5.63 0.33 4.52e-8 Electroencephalogram traits; CESC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg08888203 chr3:10149979 C3orf24 0.48 6.18 0.35 2.43e-9 Alzheimer's disease; CESC trans rs78049276 0.736 rs73855810 chr4:148383424 G/A cg13149281 chr14:23389818 RBM23;PRMT5 -0.61 -6.6 -0.38 2.24e-10 Pulse pressure; CESC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg22143856 chr6:28129313 ZNF389 0.42 5.28 0.31 2.73e-7 Depression; CESC cis rs7116495 0.541 rs579320 chr11:71794954 G/T cg26138937 chr11:71823887 C11orf51 -0.86 -7.03 -0.4 1.75e-11 Severe influenza A (H1N1) infection; CESC cis rs8002861 0.905 rs12428350 chr13:44446161 G/A cg19180546 chr13:44453867 C13orf31;CCDC122 -0.47 -5.85 -0.34 1.47e-8 Leprosy; CESC cis rs951366 0.677 rs1775140 chr1:205672107 C/A cg24503407 chr1:205819492 PM20D1 0.8 12.37 0.61 4.69e-28 Menarche (age at onset); CESC cis rs7188697 0.922 rs37057 chr16:58561954 T/C cg02549819 chr16:58548995 SETD6 -0.41 -5.21 -0.3 3.79e-7 QT interval; CESC cis rs7020830 0.898 rs13290794 chr9:37183628 C/T cg14294708 chr9:37120828 ZCCHC7 1.2 23.06 0.82 2.66e-65 Schizophrenia; CESC cis rs9549367 0.774 rs2287246 chr13:113889127 A/G cg18105134 chr13:113819100 PROZ -0.68 -8.29 -0.45 5.77e-15 Platelet distribution width; CESC cis rs713587 0.525 rs11687089 chr2:25082926 T/C cg01884057 chr2:25150051 NA 0.34 6.33 0.36 1.05e-9 Body mass index in non-asthmatics; CESC cis rs4919087 0.962 rs10882889 chr10:99045890 A/G cg25902810 chr10:99078978 FRAT1 0.71 10.44 0.54 1.3e-21 Monocyte count; CESC cis rs61542988 0.797 rs4329182 chr7:22882621 C/T cg13679077 chr7:22862647 TOMM7 0.61 7.47 0.42 1.18e-12 Fibrinogen levels; CESC cis rs412050 0.842 rs1530229 chr22:22300678 A/G cg17089214 chr22:22089827 YPEL1 0.63 6.05 0.35 4.88e-9 Attention deficit hyperactivity disorder; CESC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg07507251 chr3:52567010 NT5DC2 0.41 7.16 0.4 7.79e-12 Bipolar disorder; CESC cis rs9612 1.000 rs3786954 chr19:44272346 A/G cg08581076 chr19:44259116 C19orf61 0.45 5.47 0.32 1.03e-7 Exhaled nitric oxide output; CESC cis rs9811920 0.609 rs10936005 chr3:99674093 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -6.87 -0.39 4.64e-11 Axial length; CESC cis rs7208859 0.623 rs9915546 chr17:29132144 G/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.1e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg19717773 chr7:2847554 GNA12 -0.55 -8.68 -0.47 4.21e-16 Height; CESC cis rs9287719 0.967 rs1541573 chr2:10773385 T/G cg00105475 chr2:10696890 NA 0.37 5.2 0.3 4.04e-7 Prostate cancer; CESC cis rs12824058 0.737 rs11060829 chr12:130814996 G/T cg24838063 chr12:130822603 PIWIL1 0.62 8.55 0.47 9.78e-16 Menopause (age at onset); CESC cis rs4253772 0.550 rs6008762 chr22:46736228 T/C cg18190219 chr22:46762943 CELSR1 -0.56 -5.96 -0.34 8.1e-9 LDL cholesterol;Cholesterol, total; CESC cis rs796364 0.806 rs11688194 chr2:200916239 C/T cg23649088 chr2:200775458 C2orf69 -0.55 -5.05 -0.3 8.29e-7 Schizophrenia; CESC cis rs56235845 0.694 rs6875461 chr5:176754665 C/T cg17509989 chr5:176798049 RGS14 -0.51 -6.5 -0.37 3.93e-10 Hemoglobin concentration;Hematocrit; CESC cis rs9894429 0.738 rs8077038 chr17:79577127 T/G cg13777783 chr17:79615861 NA 0.33 5.24 0.31 3.35e-7 Eye color traits; CESC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg18402987 chr7:1209562 NA 0.76 7.57 0.42 6.04e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7851660 0.844 rs10119760 chr9:100624602 G/C cg13688889 chr9:100608707 NA -0.63 -8.94 -0.48 6.87e-17 Strep throat; CESC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg24846343 chr22:24311635 DDTL -0.62 -10.56 -0.54 5.59e-22 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs12310956 0.532 rs11052951 chr12:33986181 T/A cg26384229 chr12:38710491 ALG10B 0.45 6.22 0.36 1.98e-9 Morning vs. evening chronotype; CESC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg02569458 chr12:86230093 RASSF9 0.5 7.53 0.42 7.91e-13 Major depressive disorder; CESC cis rs1953600 0.668 rs751740 chr10:81912179 T/C cg04850286 chr10:81895943 PLAC9 0.31 5.35 0.31 1.88e-7 Sarcoidosis; CESC cis rs6991838 0.557 rs67046768 chr8:66489721 A/G cg13398993 chr8:66546079 ARMC1 -0.46 -5.54 -0.32 7.22e-8 Intelligence (multi-trait analysis); CESC cis rs7590720 0.959 rs2372684 chr2:216884764 C/A cg12620499 chr2:216877984 MREG 0.95 12.81 0.62 1.5e-29 Alcohol dependence; CESC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg24675658 chr1:53192096 ZYG11B 0.77 11.76 0.59 5.48e-26 Monocyte count; CESC trans rs7246760 0.748 rs28384439 chr19:9731965 G/A cg02900749 chr2:68251473 NA -0.79 -6.01 -0.35 6.27e-9 Pursuit maintenance gain; CESC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg06481639 chr22:41940642 POLR3H -0.55 -5.31 -0.31 2.31e-7 Vitiligo; CESC cis rs8020095 0.571 rs10136043 chr14:67440238 C/G cg19548862 chr14:67692701 FAM71D -0.5 -6.09 -0.35 4.04e-9 Depression (quantitative trait); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg13944219 chr5:65440479 SFRS12 -0.44 -6.36 -0.36 8.72e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9291683 0.546 rs13120348 chr4:10053155 C/G cg00071950 chr4:10020882 SLC2A9 -0.81 -14.74 -0.67 2.5e-36 Bone mineral density; CESC cis rs854765 0.505 rs4506969 chr17:17899839 A/G cg16928487 chr17:17741425 SREBF1 -0.54 -9.09 -0.49 2.4e-17 Total body bone mineral density; CESC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg10053473 chr17:62856997 LRRC37A3 -0.69 -7.56 -0.42 6.41e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs3741404 0.665 rs594461 chr11:63872543 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 9.9 0.52 7.19e-20 Platelet count; CESC trans rs1814175 0.562 rs1794130 chr11:49903764 T/A cg03929089 chr4:120376271 NA -0.92 -15.2 -0.68 6e-38 Height; CESC cis rs9914544 1.000 rs67411574 chr17:18797337 A/G cg26378065 chr17:18585709 ZNF286B 0.46 5.7 0.33 3.25e-8 Educational attainment (years of education); CESC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg04414720 chr1:150670196 GOLPH3L -0.46 -5.91 -0.34 1.08e-8 Urate levels; CESC cis rs2354432 0.607 rs4314933 chr1:146821386 T/C cg25205988 chr1:146714368 CHD1L 0.98 9.04 0.49 3.47e-17 Mitochondrial DNA levels; CESC cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg05343316 chr1:45956843 TESK2 -0.51 -6.75 -0.38 9.49e-11 High light scatter reticulocyte count; CESC cis rs1957429 0.803 rs10873177 chr14:65318228 G/C cg23373153 chr14:65346875 NA 0.87 10.01 0.52 3.32e-20 Pediatric areal bone mineral density (radius); CESC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg17971929 chr21:40555470 PSMG1 1.07 16.31 0.71 7.07e-42 Cognitive function; CESC cis rs4892230 1 rs4892230 chr18:72155572 G/A cg25817165 chr18:72167213 CNDP2 -0.44 -5.9 -0.34 1.09e-8 Mononucleosis; CESC cis rs929354 0.605 rs7806314 chr7:156946903 A/T cg05182265 chr7:156933206 UBE3C -0.5 -7.18 -0.4 7.24e-12 Body mass index; CESC cis rs7772486 0.875 rs9403770 chr6:146423334 C/T cg05347473 chr6:146136440 FBXO30 0.51 6.68 0.38 1.37e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg13393036 chr8:95962371 TP53INP1 -0.35 -6.55 -0.37 2.99e-10 Type 2 diabetes; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14258078 chr17:62051773 SCN4A -0.4 -7.93 -0.44 6.03e-14 Gut microbiota (bacterial taxa); CESC cis rs4689592 0.503 rs56099074 chr4:7071259 A/G cg06697600 chr4:7070879 GRPEL1 0.52 6.56 0.37 2.81e-10 Monocyte percentage of white cells; CESC cis rs55986470 0.817 rs11883735 chr2:239407644 G/A cg18131467 chr2:239335373 ASB1 -0.57 -5.03 -0.3 9.16e-7 Chronotype; CESC cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg03467027 chr4:99064603 C4orf37 0.46 5.82 0.34 1.74e-8 Colonoscopy-negative controls vs population controls; CESC cis rs2985684 0.948 rs2883437 chr14:50031666 A/G cg04989706 chr14:50066350 PPIL5 -0.46 -5.17 -0.3 4.51e-7 Carotid intima media thickness; CESC trans rs4332037 0.624 rs58169303 chr7:1883274 T/C cg11693508 chr17:37793320 STARD3 0.6 6.01 0.35 6.17e-9 Bipolar disorder; CESC cis rs55728055 0.661 rs7288051 chr22:32013816 C/T cg01338084 chr22:32026380 PISD 1.22 8.02 0.44 3.48e-14 Age-related hearing impairment; CESC cis rs8014204 0.541 rs35591392 chr14:75157713 G/T cg08847533 chr14:75593920 NEK9 0.42 5.05 0.3 8.13e-7 Caffeine consumption; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26309655 chr1:150459725 TARS2 -0.47 -6.34 -0.36 9.85e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs561341 0.769 rs8074383 chr17:30178793 C/T cg00745463 chr17:30367425 LRRC37B 0.66 5.96 0.34 7.84e-9 Hip circumference adjusted for BMI; CESC cis rs854765 0.647 rs741782 chr17:18019712 T/C cg04398451 chr17:18023971 MYO15A -0.77 -11.36 -0.57 1.22e-24 Total body bone mineral density; CESC cis rs17253792 0.822 rs78922774 chr14:56115302 T/A cg01858014 chr14:56050164 KTN1 -0.96 -7.52 -0.42 8.3e-13 Putamen volume; CESC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg25427524 chr10:38739819 LOC399744 -0.7 -10.24 -0.53 6.01e-21 Extrinsic epigenetic age acceleration; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12713142 chr12:57081325 PTGES3 0.51 7.28 0.41 3.81e-12 Systemic lupus erythematosus; CESC cis rs9902453 0.730 rs2020939 chr17:28550732 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.56 -6.86 -0.39 4.87e-11 Coffee consumption (cups per day); CESC cis rs7044106 0.791 rs10739572 chr9:123489815 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.85 13.79 0.65 5.75e-33 Hip circumference adjusted for BMI; CESC cis rs9527 0.830 rs12249194 chr10:104643698 T/C cg04362960 chr10:104952993 NT5C2 0.45 5.28 0.31 2.69e-7 Arsenic metabolism; CESC cis rs546131 0.928 rs572690 chr11:34833614 A/G cg11058730 chr11:34937778 PDHX;APIP 0.5 6.38 0.37 7.7e-10 Lung disease severity in cystic fibrosis; CESC trans rs7819412 0.703 rs2409713 chr8:11009797 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -6.13 -0.35 3.15e-9 Triglycerides; CESC cis rs965469 1.000 rs6051672 chr20:3224819 C/T cg25506879 chr20:3388711 C20orf194 -0.65 -6.87 -0.39 4.52e-11 IFN-related cytopenia; CESC cis rs9733 0.744 rs12568757 chr1:150729793 C/T cg18016565 chr1:150552671 MCL1 -0.36 -5.93 -0.34 9.46e-9 Tonsillectomy; CESC cis rs8070740 0.898 rs9895440 chr17:5325643 C/A cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.37 0.36 8.36e-10 Menopause (age at onset); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg22627950 chr7:44622302 TMED4 -0.48 -6.47 -0.37 4.74e-10 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25820224 chr2:95787551 MRPS5 0.53 6.1 0.35 3.69e-9 Gut microbiome composition (summer); CESC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg11764359 chr7:65958608 NA 0.8 9.99 0.52 3.89e-20 Aortic root size; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg06944982 chr8:141779353 PTK2 0.44 6.32 0.36 1.09e-9 Cleft plate (environmental tobacco smoke interaction); CESC cis rs113835537 0.529 rs57634456 chr11:66250838 A/C cg22134325 chr11:66188745 NPAS4 0.33 5.27 0.31 2.78e-7 Airway imaging phenotypes; CESC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg19346786 chr7:2764209 NA -0.36 -5.13 -0.3 5.57e-7 Height; CESC cis rs7940866 0.903 rs7130842 chr11:130836269 A/G cg12179176 chr11:130786555 SNX19 0.6 8.36 0.46 3.66e-15 Schizophrenia; CESC cis rs7584330 0.554 rs77180399 chr2:238442951 G/A cg14458575 chr2:238380390 NA 0.69 6.44 0.37 5.43e-10 Prostate cancer; CESC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg16325326 chr1:53192061 ZYG11B 0.57 8.46 0.46 1.77e-15 Monocyte count; CESC cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg17366294 chr4:99064904 C4orf37 0.6 8.57 0.47 8.69e-16 Colonoscopy-negative controls vs population controls; CESC cis rs4523957 0.651 rs8068642 chr17:2060353 T/C cg16513277 chr17:2031491 SMG6 -0.72 -10.2 -0.53 8.12e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7542091 0.666 rs7537070 chr1:210043565 A/G cg25204440 chr1:209979598 IRF6 0.37 5.1 0.3 6.55e-7 Monobrow; CESC cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg04317338 chr11:64019027 PLCB3 0.69 5.93 0.34 9.3e-9 Mean platelet volume; CESC trans rs11098499 0.863 rs6858592 chr4:120458692 G/A cg25214090 chr10:38739885 LOC399744 0.7 9.72 0.51 2.7e-19 Corneal astigmatism; CESC cis rs9457247 1.000 rs376551 chr6:167384923 G/A cg07741184 chr6:167504864 NA 0.31 5.53 0.32 7.76e-8 Crohn's disease; CESC cis rs854765 0.547 rs6502633 chr17:17941037 G/C cg04398451 chr17:18023971 MYO15A -0.73 -10.55 -0.54 6.12e-22 Total body bone mineral density; CESC cis rs7312933 0.701 rs10880260 chr12:42561398 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 5.99 0.35 6.93e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs4330281 0.740 rs4349529 chr3:17792118 A/G cg20981856 chr3:17787350 NA 0.36 5.06 0.3 7.8e-7 Schizophrenia; CESC trans rs997295 0.529 rs12592315 chr15:68040266 A/G cg02522757 chr12:48298992 VDR 0.47 6.04 0.35 5.09e-9 Motion sickness; CESC trans rs74054849 0.850 rs112167764 chr1:16016551 G/A cg06826283 chr7:600452 PRKAR1B 0.69 6.12 0.35 3.34e-9 Alcoholic chronic pancreatitis; CESC cis rs9790314 1.000 rs62279921 chr3:161065441 T/C cg03342759 chr3:160939853 NMD3 -0.45 -5.86 -0.34 1.37e-8 Morning vs. evening chronotype; CESC cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.78 12.99 0.62 3.48e-30 Personality dimensions; CESC cis rs7246657 0.943 rs4803229 chr19:37864682 T/G cg23950597 chr19:37808831 NA -0.55 -6.09 -0.35 3.96e-9 Coronary artery calcification; CESC cis rs6963495 0.769 rs117986187 chr7:105167311 G/A cg13798780 chr7:105162888 PUS7 0.78 8.02 0.44 3.36e-14 Bipolar disorder (body mass index interaction); CESC cis rs10870270 1.000 rs4880263 chr10:133787629 C/T cg17892150 chr10:133769511 PPP2R2D -0.86 -12.51 -0.61 1.56e-28 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg11965913 chr1:205819406 PM20D1 0.82 13.95 0.65 1.49e-33 Menarche (age at onset); CESC cis rs7247513 0.790 rs8112964 chr19:12752173 C/T cg01871581 chr19:12707946 ZNF490 -0.79 -11.89 -0.59 2.06e-26 Bipolar disorder; CESC cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.08 0.3 7.13e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9796 0.558 rs11855102 chr15:41513257 T/C cg18705301 chr15:41695430 NDUFAF1 -0.45 -6.77 -0.38 8.07e-11 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21387238 chr1:155829263 SYT11 0.67 7.63 0.42 4.2e-13 Gut microbiome composition (summer); CESC cis rs911555 0.576 rs8015723 chr14:103895909 A/G cg12935359 chr14:103987150 CKB 0.47 6.33 0.36 1.06e-9 Intelligence (multi-trait analysis); CESC cis rs524281 0.861 rs10791855 chr11:65963737 A/G cg14036092 chr11:66035641 RAB1B -0.58 -6.15 -0.35 2.79e-9 Electroencephalogram traits; CESC cis rs888194 0.544 rs2196612 chr12:109849535 A/G cg19025524 chr12:109796872 NA -0.46 -6.64 -0.38 1.77e-10 Neuroticism; CESC cis rs425277 0.585 rs3128294 chr1:2065343 G/C cg24578937 chr1:2090814 PRKCZ -0.36 -6.11 -0.35 3.46e-9 Height; CESC cis rs17376456 0.877 rs10073039 chr5:93467709 A/G cg21475434 chr5:93447410 FAM172A 0.85 7.6 0.42 5.01e-13 Diabetic retinopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23603076 chr14:24605279 PSME1 0.62 7.1 0.4 1.17e-11 Gut microbiome composition (summer); CESC cis rs708547 0.581 rs13121027 chr4:57813369 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.54 -7.04 -0.4 1.69e-11 Response to bleomycin (chromatid breaks); CESC cis rs7809799 1.000 rs1918019 chr7:98763419 G/A cg05967295 chr7:98741636 SMURF1 -0.77 -5.41 -0.32 1.37e-7 Ulcerative colitis; CESC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 6.51 0.37 3.65e-10 Prudent dietary pattern; CESC cis rs7824557 0.603 rs2250028 chr8:11213589 T/G cg21775007 chr8:11205619 TDH 0.54 7.73 0.43 2.26e-13 Retinal vascular caliber; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24441975 chr1:39339062 MYCBP 0.54 6.45 0.37 5.37e-10 Gut microbiome composition (summer); CESC cis rs9291683 0.588 rs2240721 chr4:10020564 G/A cg11266682 chr4:10021025 SLC2A9 0.72 14.84 0.67 1.1e-36 Bone mineral density; CESC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg02725872 chr8:58115012 NA -0.45 -6.84 -0.39 5.31e-11 Developmental language disorder (linguistic errors); CESC cis rs951366 0.677 rs1775140 chr1:205672107 C/A cg07167872 chr1:205819463 PM20D1 0.76 11.92 0.59 1.64e-26 Menarche (age at onset); CESC cis rs8017423 0.967 rs8015510 chr14:90729984 C/T cg14092571 chr14:90743983 NA -0.56 -8.38 -0.46 3.07e-15 Mortality in heart failure; CESC cis rs9926296 0.632 rs2011925 chr16:89814064 T/G cg04287289 chr16:89883240 FANCA 0.63 8.1 0.45 2.05e-14 Vitiligo; CESC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg01416388 chr22:39784598 NA -0.49 -6.46 -0.37 4.91e-10 Intelligence (multi-trait analysis); CESC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg06456125 chr7:65229604 NA 0.43 5.6 0.33 5.49e-8 Calcium levels; CESC cis rs11630290 0.736 rs72752925 chr15:64146100 C/G cg12036633 chr15:63758958 NA -0.55 -5.09 -0.3 6.87e-7 Iris characteristics; CESC cis rs7762018 1.000 rs60253563 chr6:170083019 T/C cg05834625 chr6:170176447 C6orf70 0.62 7.41 0.41 1.7e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg02228804 chr6:27775720 HIST1H2AI;HIST1H2BL 0.64 5.58 0.32 6e-8 Depression; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg26400300 chr15:44829086 EIF3J -0.41 -6.35 -0.36 9.23e-10 Gambling; CESC cis rs13223928 0.538 rs10951042 chr7:3139417 T/C cg19214707 chr7:3157722 NA -0.42 -5.77 -0.33 2.25e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; CESC trans rs4424809 1.000 rs57685252 chr13:85277355 C/T cg22095490 chr18:77560089 NA -0.87 -6.37 -0.36 8.48e-10 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs6867032 0.876 rs1552435 chr5:2018378 A/G cg26168224 chr5:2018326 NA 1.04 23.88 0.83 5.34e-68 Gut microbiome composition (winter); CESC cis rs8114671 0.562 rs6088622 chr20:33419977 C/A cg06115741 chr20:33292138 TP53INP2 0.45 5.31 0.31 2.37e-7 Height; CESC cis rs1153858 1.000 rs11852800 chr15:45639131 A/G cg21132104 chr15:45694354 SPATA5L1 -0.82 -10.88 -0.56 4.84e-23 Homoarginine levels; CESC cis rs3749237 0.595 rs1464566 chr3:49459376 T/C cg07636037 chr3:49044803 WDR6 0.6 8.8 0.48 1.74e-16 Resting heart rate; CESC cis rs634534 0.562 rs1151505 chr11:65734539 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.64 8.87 0.48 1.12e-16 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs1401999 0.690 rs6773408 chr3:183716609 G/T cg01324343 chr3:183735012 ABCC5 0.56 11.27 0.57 2.46e-24 Anterior chamber depth; CESC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg21644426 chr2:191273491 MFSD6 0.46 6.3 0.36 1.26e-9 Pulse pressure; CESC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg21782813 chr7:2030301 MAD1L1 0.37 5.15 0.3 5.05e-7 Schizophrenia; CESC cis rs9611565 0.649 rs79005 chr22:41835544 G/A cg06481639 chr22:41940642 POLR3H 0.52 5.68 0.33 3.48e-8 Vitiligo; CESC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg22800045 chr5:56110881 MAP3K1 0.77 9.06 0.49 2.91e-17 Initial pursuit acceleration; CESC cis rs2463822 0.844 rs72923263 chr11:62161170 C/G cg06239285 chr11:62104954 ASRGL1 -1.07 -9.26 -0.49 7.43e-18 Chronic obstructive pulmonary disease-related biomarkers; CESC cis rs2760061 0.659 rs708107 chr1:228189495 C/T cg02753203 chr1:228287806 NA 0.53 7.79 0.43 1.52e-13 Diastolic blood pressure; CESC cis rs12325245 0.536 rs12709002 chr16:58614337 A/C cg01152986 chr16:58549298 SETD6 0.9 5.47 0.32 1.02e-7 Schizophrenia; CESC cis rs56235845 0.964 rs11741640 chr5:176792743 G/A cg16006841 chr5:176797999 RGS14 0.59 6.32 0.36 1.13e-9 Hemoglobin concentration;Hematocrit; CESC cis rs4979906 1.000 rs11002241 chr10:79445327 C/T cg07817648 chr10:79422355 NA -0.61 -6.46 -0.37 5.08e-10 Mortality in heart failure; CESC cis rs1707322 0.721 rs11211166 chr1:46157942 G/A cg03146154 chr1:46216737 IPP 0.82 11.58 0.58 2.25e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg08859206 chr1:53392774 SCP2 -0.57 -7.38 -0.41 2.02e-12 Monocyte count; CESC cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg12826209 chr6:26865740 GUSBL1 0.73 8.13 0.45 1.7e-14 Intelligence (multi-trait analysis); CESC trans rs4843747 0.671 rs13334603 chr16:88116016 T/C cg26811252 chr16:29126840 RRN3P2 0.72 10.04 0.52 2.53e-20 Menopause (age at onset); CESC cis rs7508 0.668 rs13280 chr8:17921230 G/A cg18067069 chr8:17937731 ASAH1 -0.4 -5.36 -0.31 1.82e-7 Atrial fibrillation; CESC cis rs644799 1.000 rs546809 chr11:95579938 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.7 8.76 0.47 2.41e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg11663144 chr21:46675770 NA 0.59 9.45 0.5 1.91e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs76878669 0.561 rs4930177 chr11:66120784 T/C cg18002602 chr11:66138449 SLC29A2 0.4 6.65 0.38 1.71e-10 Educational attainment (years of education); CESC cis rs6964587 1.000 rs58965837 chr7:91585258 T/A cg17063962 chr7:91808500 NA 0.57 7.67 0.43 3.21e-13 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07156820 chr17:54821256 NA -0.53 -6.08 -0.35 4.16e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs13122456 chr4:98936011 A/G cg05340658 chr4:99064831 C4orf37 0.82 12.54 0.61 1.29e-28 Colonoscopy-negative controls vs population controls; CESC cis rs7647973 0.769 rs4974081 chr3:49070499 A/G cg07636037 chr3:49044803 WDR6 -0.82 -11.49 -0.58 4.46e-25 Menarche (age at onset); CESC cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg23711669 chr6:146136114 FBXO30 1.0 14.39 0.66 4.21e-35 Lobe attachment (rater-scored or self-reported); CESC cis rs6121246 0.529 rs6060171 chr20:30183269 C/T cg13852791 chr20:30311386 BCL2L1 0.57 5.5 0.32 9.14e-8 Mean corpuscular hemoglobin; CESC cis rs11148252 0.508 rs11148260 chr13:53162643 A/C cg00495681 chr13:53174319 NA 0.55 7.55 0.42 6.84e-13 Lewy body disease; CESC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg22433210 chr17:43662623 NA 0.98 11.32 0.57 1.66e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9611565 0.694 rs202641 chr22:41833116 C/T cg17376030 chr22:41985996 PMM1 -0.55 -6.13 -0.35 3.17e-9 Vitiligo; CESC cis rs2708240 0.936 rs2538976 chr7:147585819 T/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.33 -5.69 -0.33 3.39e-8 QT interval (drug interaction); CESC cis rs2439831 0.850 rs7163245 chr15:43671294 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.86 13.09 0.63 1.57e-30 Lung cancer in ever smokers; CESC trans rs1667255 0.830 rs2034404 chr18:29156302 A/G cg19990402 chr19:37019372 ZNF260 0.49 6.22 0.36 1.92e-9 Retinol levels; CESC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.36 -6.83 -0.39 5.84e-11 Electroencephalogram traits; CESC cis rs11112613 0.713 rs11112586 chr12:105939816 C/T cg03607813 chr12:105948248 NA 0.58 6.62 0.38 2e-10 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg00684032 chr4:1343700 KIAA1530 0.41 5.79 0.33 2.03e-8 Obesity-related traits; CESC cis rs2239547 0.618 rs2071041 chr3:52864693 T/G cg11645453 chr3:52864694 ITIH4 0.39 7.19 0.4 6.45e-12 Schizophrenia; CESC cis rs4268898 0.722 rs6723257 chr2:24391129 A/G cg06627628 chr2:24431161 ITSN2 0.53 6.97 0.39 2.47e-11 Asthma; CESC cis rs7216064 0.734 rs12942774 chr17:65967562 A/G cg12091567 chr17:66097778 LOC651250 0.57 7.22 0.41 5.57e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs116095464 0.558 rs6866776 chr5:264495 C/T cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.51e-10 Breast cancer; CESC cis rs11764590 0.694 rs6977161 chr7:2099361 T/C cg21782813 chr7:2030301 MAD1L1 -0.43 -5.44 -0.32 1.24e-7 Neuroticism; CESC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.09 -0.49 2.46e-17 Developmental language disorder (linguistic errors); CESC cis rs7937682 0.602 rs503905 chr11:111390762 G/C cg09085632 chr11:111637200 PPP2R1B -0.67 -8.92 -0.48 7.59e-17 Primary sclerosing cholangitis; CESC cis rs752010 0.715 rs11807117 chr1:42101206 C/T cg06885757 chr1:42089581 HIVEP3 0.7 10.89 0.56 4.45e-23 Lupus nephritis in systemic lupus erythematosus; CESC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg21963583 chr11:68658836 MRPL21 0.4 5.5 0.32 8.98e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs116095464 0.558 rs7710005 chr5:233572 A/G cg10591111 chr5:226296 SDHA -0.52 -6.35 -0.36 9.15e-10 Breast cancer; CESC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.41 5.61 0.33 5.17e-8 Menopause (age at onset); CESC cis rs826838 1.000 rs10880785 chr12:38655405 T/G cg26384229 chr12:38710491 ALG10B 0.82 14.26 0.66 1.22e-34 Heart rate; CESC trans rs561341 1.000 rs527256 chr17:30321293 C/G cg27661571 chr11:113659931 NA -0.82 -7.63 -0.42 4.18e-13 Hip circumference adjusted for BMI; CESC cis rs7937682 0.575 rs34558891 chr11:111737912 C/T cg09085632 chr11:111637200 PPP2R1B 0.91 11.76 0.59 5.82e-26 Primary sclerosing cholangitis; CESC trans rs2018683 0.600 rs717891 chr7:29000374 C/T cg19402173 chr7:128379420 CALU -0.58 -7.23 -0.41 5.21e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs9486719 0.749 rs1009596 chr6:96843688 A/G cg18709589 chr6:96969512 KIAA0776 0.55 5.64 0.33 4.26e-8 Migraine;Coronary artery disease; CESC cis rs9811920 0.809 rs766778 chr3:99751480 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -7.54 -0.42 7.73e-13 Axial length; CESC cis rs7264396 0.563 rs7264869 chr20:34346502 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.87 -10.3 -0.53 3.83e-21 Total cholesterol levels; CESC cis rs9487051 0.676 rs1608041 chr6:109595903 G/A cg12927641 chr6:109611667 NA -0.37 -5.5 -0.32 8.91e-8 Reticulocyte fraction of red cells; CESC cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg20712883 chr12:51590929 POU6F1 0.44 5.28 0.31 2.72e-7 Cisplatin-induced ototoxicity; CESC cis rs921968 0.565 rs7599568 chr2:219607819 A/G cg02176678 chr2:219576539 TTLL4 -0.46 -8.25 -0.45 7.26e-15 Mean corpuscular hemoglobin concentration; CESC cis rs2777491 0.915 rs28578057 chr15:41621921 G/A cg18705301 chr15:41695430 NDUFAF1 -0.6 -8.84 -0.48 1.39e-16 Ulcerative colitis; CESC cis rs6500602 0.727 rs1477123 chr16:4560627 T/A cg08645402 chr16:4508243 NA 0.43 6.43 0.37 5.93e-10 Schizophrenia; CESC trans rs11098499 0.743 rs11098501 chr4:120252017 T/G cg25214090 chr10:38739885 LOC399744 0.62 8.7 0.47 3.58e-16 Corneal astigmatism; CESC cis rs5753618 0.555 rs5749286 chr22:31900359 G/T cg13145458 chr22:31556086 RNF185 -0.48 -5.66 -0.33 3.93e-8 Colorectal cancer; CESC cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg21573476 chr21:45109991 RRP1B -0.58 -8.38 -0.46 3.04e-15 Mean corpuscular volume; CESC cis rs362272 0.524 rs881816 chr4:3365366 A/G cg14583973 chr4:3374767 RGS12 0.31 5.49 0.32 9.61e-8 Serum sulfate level; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05731991 chr2:60983297 PAPOLG 0.57 6.24 0.36 1.77e-9 Gut microbiome composition (summer); CESC cis rs854765 0.583 rs4341796 chr17:17839024 C/A cg16928487 chr17:17741425 SREBF1 -0.6 -10.42 -0.54 1.58e-21 Total body bone mineral density; CESC cis rs992157 0.710 rs6719789 chr2:219057810 G/T cg00012203 chr2:219082015 ARPC2 -0.83 -11.93 -0.59 1.49e-26 Colorectal cancer; CESC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.6 -7.84 -0.43 1.11e-13 Prudent dietary pattern; CESC cis rs13343954 0.518 rs8106293 chr19:33536376 C/T cg03563238 chr19:33554763 RHPN2 -0.3 -5.32 -0.31 2.18e-7 Colorectal cancer; CESC cis rs7772486 0.790 rs9497424 chr6:146225271 C/A cg23711669 chr6:146136114 FBXO30 -0.83 -11.88 -0.59 2.31e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs11098499 0.913 rs10006304 chr4:120124305 A/G cg09307838 chr4:120376055 NA 0.79 9.94 0.52 5.23e-20 Corneal astigmatism; CESC cis rs959260 0.588 rs2385263 chr17:73321117 T/C cg12999837 chr17:73267436 MIF4GD -0.43 -5.19 -0.3 4.2e-7 Systemic lupus erythematosus; CESC trans rs1116547 0.602 rs112360538 chr5:112913288 A/C cg10115368 chr14:100435663 NA 0.51 6.01 0.35 6.17e-9 Cerebral amyloid angiopathy; CESC cis rs1144713 0.686 rs1144715 chr12:32261435 A/G cg01321189 chr12:32259338 BICD1 0.34 5.15 0.3 4.98e-7 Obesity-related traits; CESC cis rs72781680 0.898 rs72796158 chr2:23935727 T/C cg20701182 chr2:24300061 SF3B14 0.78 6.91 0.39 3.5e-11 Lymphocyte counts; CESC cis rs2950393 0.929 rs10747769 chr12:57070840 G/A cg05584118 chr12:57595605 LRP1 -0.38 -5.47 -0.32 1.06e-7 Platelet distribution width; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg06872588 chr7:6692873 NA 0.52 6.89 0.39 4.07e-11 Fibrinogen levels; CESC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg01802117 chr1:53393560 SCP2 -0.4 -5.12 -0.3 5.9e-7 Monocyte count; CESC cis rs34172651 0.917 rs200538 chr16:24735736 C/T cg06028605 chr16:24865363 SLC5A11 -0.37 -5.67 -0.33 3.75e-8 Intelligence (multi-trait analysis); CESC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg07395648 chr5:131743802 NA 0.42 5.52 0.32 7.92e-8 Breast cancer; CESC cis rs73058052 0.597 rs56873913 chr19:50091199 T/G cg09250473 chr19:50168907 IRF3;BCL2L12 0.47 5.07 0.3 7.65e-7 Fibrinogen levels; CESC cis rs734999 0.545 rs4474198 chr1:2553758 C/T cg18854424 chr1:2615690 NA 0.3 6.11 0.35 3.52e-9 Ulcerative colitis; CESC cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg13628971 chr7:2884303 GNA12 0.42 5.64 0.33 4.45e-8 Height; CESC cis rs793571 0.774 rs10851640 chr15:59137870 T/C cg05156742 chr15:59063176 FAM63B -0.53 -6.54 -0.37 3.16e-10 Schizophrenia; CESC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -5.08 -0.3 7.1e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs7307889 0.793 rs12301255 chr12:6008816 C/G cg18407955 chr7:158110685 PTPRN2 -0.72 -6.68 -0.38 1.41e-10 Obesity-related traits; CESC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg13114125 chr14:105738426 BRF1 -0.84 -10.37 -0.54 2.25e-21 Mean platelet volume;Platelet distribution width; CESC cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg21918786 chr6:109611834 NA -0.4 -6.01 -0.35 6.17e-9 Reticulocyte fraction of red cells; CESC cis rs1559088 0.947 rs7259879 chr19:33549462 T/C cg27124370 chr19:33622961 WDR88 0.43 5.49 0.32 9.52e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC cis rs2506889 0.553 rs11580264 chr1:10605796 C/A cg07384165 chr1:10488281 NA -0.6 -8.61 -0.47 6.59e-16 Breast cancer; CESC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9811920 0.609 rs13317017 chr3:99665521 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.64 -10.16 -0.53 1.11e-20 Axial length; CESC cis rs3806843 1.000 rs3756340 chr5:140180451 T/G cg26395211 chr5:140044315 WDR55 -0.42 -5.35 -0.31 1.94e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1018836 0.923 rs4735268 chr8:91629715 C/T cg16814680 chr8:91681699 NA -0.73 -10.54 -0.54 6.47e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs9811920 0.609 rs7636447 chr3:99612677 G/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.59 7.22 0.41 5.61e-12 Axial length; CESC cis rs11098499 0.874 rs9995277 chr4:120108603 G/A cg09307838 chr4:120376055 NA 0.67 8.27 0.45 6.71e-15 Corneal astigmatism; CESC cis rs2439831 0.618 rs8023508 chr15:44176103 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.61 -7.58 -0.42 5.81e-13 Lung cancer in ever smokers; CESC trans rs2900976 0.773 rs13033431 chr2:71993723 C/T cg01646268 chr11:14367071 RRAS2 0.51 6.48 0.37 4.54e-10 Protein quantitative trait loci; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05062674 chr16:89882627 FANCA 0.51 6.2 0.36 2.1e-9 Gut microbiome composition (summer); CESC cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.33 5.1 0.3 6.43e-7 Hip circumference adjusted for BMI; CESC cis rs2235642 0.821 rs2281236 chr16:1603576 G/A cg03715980 chr16:1756201 MAPK8IP3 0.38 5.04 0.3 8.44e-7 Coronary artery disease; CESC cis rs2637266 0.935 rs2583058 chr10:78396018 T/A cg18941641 chr10:78392320 NA 0.45 8.5 0.46 1.43e-15 Pulmonary function; CESC cis rs854765 0.964 rs854813 chr17:18003845 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.47 -5.98 -0.34 7.09e-9 Total body bone mineral density; CESC cis rs2637266 0.902 rs2583056 chr10:78399498 A/G cg18941641 chr10:78392320 NA 0.44 8.56 0.47 9.37e-16 Pulmonary function; CESC cis rs7605827 0.930 rs6704723 chr2:15599895 A/G cg19274914 chr2:15703543 NA 0.34 6.09 0.35 4.01e-9 Educational attainment (years of education); CESC cis rs9768139 0.935 rs7782393 chr7:158120486 G/A cg06219351 chr7:158114137 PTPRN2 0.48 7.48 0.42 1.12e-12 Calcium levels; CESC cis rs4268898 0.662 rs72795824 chr2:24435837 T/C cg06627628 chr2:24431161 ITSN2 -1.02 -11.2 -0.57 4.2e-24 Asthma; CESC cis rs9768139 0.733 rs34173461 chr7:158122175 C/G cg25566285 chr7:158114605 PTPRN2 0.47 7.67 0.43 3.24e-13 Calcium levels; CESC cis rs1707322 0.717 rs3014237 chr1:46090252 A/G cg06784218 chr1:46089804 CCDC17 -0.41 -7.08 -0.4 1.26e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1044826 0.518 rs295488 chr3:139239323 C/T cg15131784 chr3:139108705 COPB2 0.41 5.25 0.31 3.19e-7 Obesity-related traits; CESC cis rs2797160 0.904 rs1777198 chr6:126007416 C/T cg05901451 chr6:126070800 HEY2 0.46 6.5 0.37 4.07e-10 Endometrial cancer; CESC cis rs763512 0.504 rs853216 chr17:35863008 G/A cg16670864 chr17:35848621 DUSP14 0.44 5.58 0.32 5.93e-8 3-hydroxypropylmercapturic acid levels in smokers; CESC cis rs6088580 0.601 rs6059827 chr20:33016358 C/T cg08999081 chr20:33150536 PIGU 0.64 11.3 0.57 1.92e-24 Glomerular filtration rate (creatinine); CESC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg07507251 chr3:52567010 NT5DC2 0.42 7.21 0.4 5.85e-12 Bipolar disorder; CESC cis rs7246657 0.943 rs3745765 chr19:37854235 G/T cg23950597 chr19:37808831 NA -0.55 -6.04 -0.35 5.1e-9 Coronary artery calcification; CESC cis rs2742417 0.603 rs2742456 chr3:45767176 C/T cg04837898 chr3:45731254 SACM1L -0.47 -6.16 -0.35 2.75e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs763014 0.833 rs3743903 chr16:632736 T/C cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC cis rs2204008 0.775 rs12369238 chr12:38176051 A/G cg13010199 chr12:38710504 ALG10B 0.48 5.91 0.34 1.02e-8 Bladder cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg08276543 chr12:124856791 NCOR2 0.46 6.29 0.36 1.29e-9 Fibrinogen levels; CESC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg18240062 chr17:79603768 NPLOC4 0.72 10.27 0.53 4.71e-21 Eye color traits; CESC cis rs7917772 0.503 rs746552 chr10:104342501 A/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.33 -0.36 1.07e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs3617 0.573 rs9810807 chr3:52924227 C/T cg07507251 chr3:52567010 NT5DC2 -0.32 -5.39 -0.31 1.54e-7 Red blood cell count;Autism spectrum disorder or schizophrenia; CESC cis rs9815354 0.812 rs73069213 chr3:41940590 G/A cg03022575 chr3:42003672 ULK4 0.71 6.44 0.37 5.46e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg05368731 chr17:41323189 NBR1 0.78 10.79 0.55 9.37e-23 Menopause (age at onset); CESC cis rs963731 0.737 rs10194374 chr2:39244914 G/A cg04010122 chr2:39346883 SOS1 -0.69 -5.21 -0.3 3.87e-7 Corticobasal degeneration; CESC cis rs2933343 0.729 rs1680780 chr3:128612659 G/C cg24203234 chr3:128598194 ACAD9 0.4 5.19 0.3 4.13e-7 IgG glycosylation; CESC cis rs8070624 0.543 rs57728924 chr17:17875342 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.6 7.71 0.43 2.59e-13 Total body bone mineral density; CESC cis rs7520050 0.966 rs785495 chr1:46587887 A/G cg03146154 chr1:46216737 IPP -0.45 -5.8 -0.34 1.93e-8 Red blood cell count;Reticulocyte count; CESC cis rs2479106 0.963 rs4838074 chr9:126467202 C/T cg16191174 chr9:126692580 DENND1A 0.47 6.47 0.37 4.59e-10 Polycystic ovary syndrome; CESC cis rs60871478 0.579 rs56109762 chr7:925967 G/A cg15782153 chr7:917662 C7orf20 0.56 5.36 0.31 1.85e-7 Cerebrospinal P-tau181p levels; CESC cis rs2011503 1.000 rs8111093 chr19:19505548 C/T cg11584989 chr19:19387371 SF4 0.63 7.42 0.41 1.63e-12 Bipolar disorder; CESC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC cis rs6502050 0.835 rs12945993 chr17:80129485 T/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.42 -0.37 6.37e-10 Life satisfaction; CESC cis rs17376456 0.825 rs72786702 chr5:93254656 A/C cg17533458 chr5:92956826 FAM172A;MIR2277 0.65 5.32 0.31 2.22e-7 Diabetic retinopathy; CESC cis rs7539624 0.588 rs1419305 chr1:223912748 C/T cg10100437 chr1:223903862 CAPN2 0.43 5.57 0.32 6.23e-8 Schizophrenia; CESC cis rs6674176 0.932 rs4660761 chr1:44440146 G/A cg13606994 chr1:44402422 ARTN -0.4 -5.73 -0.33 2.75e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs959260 0.925 rs7207506 chr17:73409410 T/C cg20590849 chr17:73267439 MIF4GD -0.55 -6.38 -0.37 7.73e-10 Systemic lupus erythematosus; CESC cis rs17431357 1.000 rs73225218 chr12:120952310 T/C cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg13918804 chr1:2043761 PRKCZ 0.27 5.04 0.3 8.46e-7 Height; CESC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg27170947 chr2:26402098 FAM59B 0.87 9.85 0.52 1.01e-19 Gut microbiome composition (summer); CESC cis rs2859741 0.967 rs822854 chr1:37485788 A/G cg09363841 chr1:37513479 NA -0.55 -8.55 -0.46 1.01e-15 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs4975616 0.869 rs465498 chr5:1325803 A/G cg07493874 chr5:1342172 CLPTM1L -0.41 -7.87 -0.44 8.84e-14 Lung cancer; CESC cis rs6500395 0.926 rs11076571 chr16:48598064 A/G cg04672837 chr16:48644449 N4BP1 0.46 5.54 0.32 7.22e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4654899 1.000 rs61117207 chr1:21394374 A/C cg05370193 chr1:21551575 ECE1 0.39 5.84 0.34 1.55e-8 Superior frontal gyrus grey matter volume; CESC cis rs10493773 0.609 rs11161660 chr1:86184066 C/T cg17807903 chr1:86174739 ZNHIT6 -0.44 -6.59 -0.38 2.4e-10 Urate levels in overweight individuals; CESC cis rs561341 1.000 rs501312 chr17:30329066 A/G cg23018236 chr17:30244563 NA -0.53 -5.14 -0.3 5.32e-7 Hip circumference adjusted for BMI; CESC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg07308232 chr7:1071921 C7orf50 -0.46 -6.32 -0.36 1.08e-9 Longevity;Endometriosis; CESC cis rs2882667 0.858 rs6596460 chr5:138414180 G/A cg04439458 chr5:138467593 SIL1 -0.33 -5.27 -0.31 2.81e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs977987 0.806 rs11149832 chr16:75462713 C/T cg03315344 chr16:75512273 CHST6 0.41 5.91 0.34 1.07e-8 Dupuytren's disease; CESC cis rs72781680 1.000 rs72781671 chr2:24231123 A/G cg20701182 chr2:24300061 SF3B14 0.82 7.03 0.4 1.77e-11 Lymphocyte counts; CESC cis rs4803468 1.000 rs2304242 chr19:41944616 G/T cg14132834 chr19:41945861 ATP5SL 0.69 8.61 0.47 6.75e-16 Height; CESC cis rs965469 0.779 rs2236115 chr20:3296279 G/A cg25506879 chr20:3388711 C20orf194 -0.48 -5.35 -0.31 1.92e-7 IFN-related cytopenia; CESC cis rs7772486 0.754 rs4566902 chr6:146244128 A/G cg05347473 chr6:146136440 FBXO30 -0.55 -7.05 -0.4 1.57e-11 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05491930 chr6:99872786 SFRS18 0.53 6.24 0.36 1.75e-9 Gut microbiome composition (summer); CESC cis rs6460942 1.000 rs2053382 chr7:12400587 A/G cg17427002 chr7:12443146 VWDE -0.51 -5.08 -0.3 7.26e-7 Coronary artery disease; CESC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg16680214 chr1:154839983 KCNN3 -0.47 -7.26 -0.41 4.36e-12 Prostate cancer; CESC cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg16339924 chr4:17578868 LAP3 -0.62 -7.88 -0.44 8.76e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.39 -5.05 -0.3 8.08e-7 Intelligence (multi-trait analysis); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg18022570 chr8:27950479 ELP3 -0.48 -6.19 -0.36 2.24e-9 Fibrinogen levels; CESC cis rs9910055 0.571 rs10208 chr17:42300278 C/T cg19774624 chr17:42201019 HDAC5 -0.54 -7.62 -0.42 4.47e-13 Total body bone mineral density; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07590406 chr3:58292066 RPP14 0.48 6.18 0.35 2.41e-9 Gut microbiota (bacterial taxa); CESC cis rs9359856 0.517 rs72919948 chr6:90509389 C/T cg13799429 chr6:90582589 CASP8AP2 -0.64 -6.11 -0.35 3.61e-9 Bipolar disorder; CESC cis rs17376456 0.877 rs17083462 chr5:93462401 T/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.43 0.32 1.3e-7 Diabetic retinopathy; CESC cis rs9814567 0.896 rs13089566 chr3:134349710 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.42 5.67 0.33 3.77e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs7714584 0.826 rs34005003 chr5:150225199 C/T cg22134413 chr5:150180641 NA 0.52 5.64 0.33 4.31e-8 Crohn's disease; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg21863207 chr12:104234989 NT5DC3 -0.45 -6.34 -0.36 9.98e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs10242455 0.867 rs2687075 chr7:99314986 A/G cg07715041 chr7:99302981 CYP3A7 -0.43 -5.42 -0.32 1.36e-7 Blood metabolite levels; CESC cis rs17407555 1.000 rs17407555 chr4:10274994 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -5.26 -0.31 2.96e-7 Schizophrenia (age at onset); CESC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg18305652 chr10:134549665 INPP5A 0.45 6.26 0.36 1.53e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs919433 0.783 rs788007 chr2:198233676 T/G cg10820045 chr2:198174542 NA 0.41 5.93 0.34 9.6e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CESC cis rs6598955 0.543 rs61608823 chr1:26555090 G/A cg04990556 chr1:26633338 UBXN11 0.83 9.29 0.5 5.95e-18 Obesity-related traits; CESC cis rs5769707 0.642 rs135880 chr22:50018654 T/A cg20744362 chr22:50050164 C22orf34 0.39 6.07 0.35 4.52e-9 Monocyte count;Monocyte percentage of white cells; CESC cis rs6456156 0.586 rs7762156 chr6:167485831 A/T cg23791538 chr6:167370224 RNASET2 -0.5 -6.37 -0.36 8.51e-10 Primary biliary cholangitis; CESC cis rs7592578 0.771 rs4439990 chr2:191398353 A/C cg27211696 chr2:191398769 TMEM194B -0.59 -5.3 -0.31 2.39e-7 Diastolic blood pressure; CESC trans rs801193 0.844 rs2244022 chr7:66202430 A/G cg26939375 chr7:64535504 NA 0.54 7.53 0.42 8.04e-13 Aortic root size; CESC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg18337363 chr3:52569053 NT5DC2 0.29 5.29 0.31 2.51e-7 Electroencephalogram traits; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07589201 chr19:9546257 ZNF266 0.63 7.77 0.43 1.77e-13 Gut microbiome composition (summer); CESC cis rs6546550 0.935 rs2872075 chr2:70068635 G/T cg02498382 chr2:70120550 SNRNP27 -0.37 -6.39 -0.37 7.3e-10 Prevalent atrial fibrillation; CESC trans rs4332037 0.624 rs11764124 chr7:1891723 C/G cg11693508 chr17:37793320 STARD3 0.6 6.12 0.35 3.27e-9 Bipolar disorder; CESC cis rs941408 0.515 rs7253128 chr19:2776982 C/T cg00079169 chr19:2811669 THOP1 0.38 5.21 0.3 3.88e-7 Total cholesterol levels; CESC cis rs9399135 0.967 rs17638970 chr6:135320063 A/G cg22676075 chr6:135203613 NA 0.51 7.23 0.41 5.22e-12 Red blood cell count; CESC cis rs79057730 0.599 rs112891948 chr7:816059 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.93 7.96 0.44 5.2e-14 Initial pursuit acceleration; CESC cis rs13242816 1.000 rs1018859 chr7:116067347 C/T cg04696780 chr7:116139425 CAV2 -0.62 -5.58 -0.32 6.03e-8 P wave duration; CESC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg21747405 chr11:67723411 NA -0.42 -6.62 -0.38 2.03e-10 Blood pressure (smoking interaction); CESC trans rs11674184 0.714 rs9789525 chr2:11724580 G/T cg14768519 chr17:79870056 SIRT7;PCYT2 -0.41 -6.03 -0.35 5.42e-9 Endometriosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26926904 chr4:186317539 ANKRD37 0.52 6.15 0.35 2.83e-9 Gut microbiome composition (summer); CESC cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg13175981 chr1:150552382 MCL1 0.62 9.23 0.49 9.06e-18 Tonsillectomy; CESC trans rs3942852 0.806 rs10769316 chr11:48119745 C/G cg03929089 chr4:120376271 NA -0.56 -6.38 -0.36 7.84e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs7267979 0.933 rs2261109 chr20:25259200 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 18.61 0.75 5.21e-50 Liver enzyme levels (alkaline phosphatase); CESC cis rs7100689 0.577 rs2342813 chr10:82046302 T/G cg09936400 chr10:82049201 MAT1A 0.38 5.9 0.34 1.12e-8 Post bronchodilator FEV1; CESC cis rs2820292 0.741 rs12086240 chr1:201885791 G/A cg11586189 chr1:201857591 SHISA4 -0.36 -6.12 -0.35 3.43e-9 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); CESC cis rs9596863 1.000 rs9596855 chr13:54407032 G/A ch.13.53330881F chr13:54432880 NA 0.66 5.25 0.31 3.08e-7 Epilepsy and lamotrigine-induced maculopapular eruptions; CESC cis rs6429082 0.660 rs10737818 chr1:235542023 A/G cg26050004 chr1:235667680 B3GALNT2 -0.54 -6.78 -0.38 7.8e-11 Adiposity; CESC cis rs9527 0.590 rs10883820 chr10:104764661 A/C cg04362960 chr10:104952993 NT5C2 -0.41 -5.18 -0.3 4.35e-7 Arsenic metabolism; CESC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg18230493 chr5:56204884 C5orf35 -0.73 -8.57 -0.47 8.93e-16 Initial pursuit acceleration; CESC cis rs6460942 0.915 rs62447641 chr7:12488764 G/A cg06484146 chr7:12443880 VWDE -0.76 -8.53 -0.46 1.11e-15 Coronary artery disease; CESC cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg05025164 chr4:1340916 KIAA1530 0.54 7.06 0.4 1.46e-11 Obesity-related traits; CESC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg21782813 chr7:2030301 MAD1L1 0.39 5.51 0.32 8.6e-8 Bipolar disorder and schizophrenia; CESC cis rs6540556 0.769 rs2272867 chr1:209929579 C/A cg05527609 chr1:210001259 C1orf107 -0.66 -7.57 -0.42 6.37e-13 Red blood cell count; CESC cis rs6951245 0.507 rs10227709 chr7:1180515 T/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.39 -5.29 -0.31 2.61e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6499255 0.904 rs7194753 chr16:69564364 A/G cg15192750 chr16:69999425 NA -0.53 -6.19 -0.36 2.22e-9 IgE levels; CESC cis rs11166629 1.000 rs7818331 chr8:135639653 C/T cg27224718 chr8:135614730 ZFAT 0.5 6.26 0.36 1.52e-9 Smoking quantity; CESC cis rs17253792 0.822 rs10148983 chr14:56051879 A/G cg01858014 chr14:56050164 KTN1 -0.87 -6.77 -0.38 8.19e-11 Putamen volume; CESC cis rs8009147 1 rs8009147 chr14:104264662 A/G cg08213375 chr14:104286397 PPP1R13B 0.54 10.8 0.55 8.68e-23 Autism spectrum disorder or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02346006 chr17:78897477 RPTOR -0.55 -6.13 -0.35 3.21e-9 Gut microbiome composition (summer); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg15684116 chr1:153700070 INTS3 0.46 6.02 0.35 5.89e-9 Gut microbiota (bacterial taxa); CESC cis rs7208859 0.623 rs170051 chr17:28914153 G/A cg19761014 chr17:28927070 LRRC37B2 0.87 6.7 0.38 1.21e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs11690935 0.959 rs10167419 chr2:172649826 A/G cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.76 -0.67 2.12e-36 Schizophrenia; CESC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg23758822 chr17:41437982 NA 1.03 15.39 0.69 1.24e-38 Menopause (age at onset); CESC cis rs9435341 0.965 rs1730859 chr1:107617707 A/G cg09367891 chr1:107599246 PRMT6 0.68 8.21 0.45 1e-14 Facial morphology (factor 21, depth of nasal alae); CESC cis rs11650494 0.831 rs7216993 chr17:47454263 A/G cg08112188 chr17:47440006 ZNF652 0.85 6.9 0.39 3.93e-11 Prostate cancer; CESC cis rs362272 0.524 rs6819202 chr4:3368264 G/A cg08886695 chr4:3369023 RGS12 -0.42 -5.82 -0.34 1.72e-8 Serum sulfate level; CESC cis rs6582630 0.537 rs11611326 chr12:38547958 C/A cg13010199 chr12:38710504 ALG10B 0.51 6.56 0.37 2.88e-10 Drug-induced liver injury (flucloxacillin); CESC cis rs17253792 0.822 rs10135426 chr14:56054644 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.82 5.99 0.35 6.73e-9 Putamen volume; CESC trans rs853679 0.546 rs200952 chr6:27836976 C/T cg06606381 chr12:133084897 FBRSL1 -0.83 -7.8 -0.43 1.44e-13 Depression; CESC cis rs6500395 1.000 rs9925406 chr16:48671436 C/A cg04672837 chr16:48644449 N4BP1 0.51 6.31 0.36 1.14e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs17685 0.725 rs4476928 chr7:75642107 C/A cg19862616 chr7:65841803 NCRNA00174 -0.86 -12.76 -0.62 2.16e-29 Coffee consumption;Coffee consumption (cups per day); CESC cis rs372883 0.648 rs2832296 chr21:30741454 C/T cg24692254 chr21:30365293 RNF160 -0.51 -6.45 -0.37 5.29e-10 Pancreatic cancer; CESC cis rs870825 0.616 rs28490461 chr4:185651638 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.96 0.39 2.74e-11 Blood protein levels; CESC cis rs7927771 0.524 rs7932703 chr11:47769936 A/C cg20307385 chr11:47447363 PSMC3 0.61 8.59 0.47 7.41e-16 Subjective well-being; CESC cis rs748404 0.690 rs2467737 chr15:43737188 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.3 0.45 5.23e-15 Lung cancer; CESC cis rs7586879 0.593 rs10198356 chr2:25130592 A/G cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.02e-11 Body mass index; CESC cis rs7666738 0.830 rs34916200 chr4:98851593 C/T cg05340658 chr4:99064831 C4orf37 0.75 11.16 0.57 5.89e-24 Colonoscopy-negative controls vs population controls; CESC cis rs2011503 0.941 rs55822665 chr19:19383298 C/T cg11584989 chr19:19387371 SF4 0.6 7.19 0.4 6.59e-12 Bipolar disorder; CESC cis rs7527798 0.592 rs11118345 chr1:207854827 A/T cg21110645 chr1:207815933 NA -0.33 -5.76 -0.33 2.33e-8 Erythrocyte sedimentation rate; CESC cis rs4862307 0.836 rs6829678 chr4:185001631 C/T cg06737308 chr4:185021514 ENPP6 -0.43 -5.8 -0.34 1.92e-8 Serum dimethylarginine levels (asymmetric/symetric ratio); CESC cis rs2050392 0.624 rs303450 chr10:30725337 C/A cg18806716 chr10:30721971 MAP3K8 -0.63 -9.55 -0.51 9.17e-19 Inflammatory bowel disease; CESC cis rs7808935 0.628 rs72598552 chr7:27939961 G/A cg05786569 chr7:27702416 HIBADH 0.52 5.79 0.34 1.97e-8 Prostate cancer; CESC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg21963583 chr11:68658836 MRPL21 0.41 5.56 0.32 6.63e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs73058052 0.597 rs7249925 chr19:50093572 A/G cg09250473 chr19:50168907 IRF3;BCL2L12 0.5 5.62 0.33 4.75e-8 Fibrinogen levels; CESC cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg23887609 chr12:130822674 PIWIL1 0.5 6.01 0.35 6.03e-9 Menopause (age at onset); CESC cis rs6088580 0.634 rs6579165 chr20:32994715 A/G cg24642439 chr20:33292090 TP53INP2 -0.53 -6.99 -0.39 2.17e-11 Glomerular filtration rate (creatinine); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg18767321 chr22:39096505 JOSD1 0.45 6.13 0.35 3.19e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2243480 1.000 rs3885839 chr7:65290403 G/T cg13147721 chr7:65941812 NA -0.9 -8.67 -0.47 4.31e-16 Diabetic kidney disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19281871 chr6:88411031 NCRNA00120;AKIRIN2 -0.56 -6.01 -0.35 6.18e-9 Gut microbiome composition (summer); CESC cis rs7481584 0.962 rs2001006 chr11:2974912 A/G cg25174290 chr11:3078921 CARS -0.46 -5.5 -0.32 8.72e-8 Calcium levels; CESC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg24768116 chr2:27665128 KRTCAP3 -0.28 -5.07 -0.3 7.42e-7 Total body bone mineral density; CESC cis rs3820928 1.000 rs10193404 chr2:227777757 A/G cg05526886 chr2:227700861 RHBDD1 -0.45 -5.9 -0.34 1.13e-8 Pulmonary function; CESC cis rs17826219 0.500 rs61685770 chr17:29085713 G/A cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Body mass index; CESC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg05564831 chr3:52568323 NT5DC2 0.47 7.34 0.41 2.57e-12 Electroencephalogram traits; CESC cis rs72945132 0.882 rs59681006 chr11:70179401 T/C cg00319359 chr11:70116639 PPFIA1 0.75 7.17 0.4 7.52e-12 Coronary artery disease; CESC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg15112475 chr7:1198522 ZFAND2A -0.41 -6.42 -0.37 6.14e-10 Longevity;Endometriosis; CESC cis rs2637266 0.846 rs752006 chr10:78393136 G/T cg18941641 chr10:78392320 NA 0.41 7.59 0.42 5.56e-13 Pulmonary function; CESC cis rs938554 0.779 rs6449173 chr4:9966105 A/C cg00071950 chr4:10020882 SLC2A9 -0.52 -6.13 -0.35 3.2e-9 Blood metabolite levels; CESC cis rs1538970 0.739 rs4660863 chr1:45955868 T/C cg05343316 chr1:45956843 TESK2 0.93 12.78 0.62 1.91e-29 Platelet count; CESC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg11764359 chr7:65958608 NA 0.87 13.29 0.63 3.14e-31 Aortic root size; CESC cis rs561341 1.000 rs527256 chr17:30321293 C/G cg19193384 chr17:30244184 NA -0.7 -6.58 -0.37 2.49e-10 Hip circumference adjusted for BMI; CESC cis rs4319547 1.000 rs10998 chr12:122989412 G/A cg05707623 chr12:122985044 ZCCHC8 -0.66 -7.62 -0.42 4.42e-13 Body mass index; CESC cis rs7107174 1.000 rs2511182 chr11:77982130 G/C cg02023728 chr11:77925099 USP35 0.47 6.49 0.37 4.19e-10 Testicular germ cell tumor; CESC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg24209194 chr3:40518798 ZNF619 0.49 6.14 0.35 3.03e-9 Renal cell carcinoma; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg25750404 chr12:6579648 VAMP1 0.47 6.24 0.36 1.68e-9 Systemic lupus erythematosus; CESC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg08968635 chr6:28129556 ZNF389 0.42 5.72 0.33 2.82e-8 Depression; CESC cis rs7243790 0.774 rs7240534 chr18:51885897 C/T cg04730925 chr18:51795821 POLI -0.42 -5.57 -0.32 6.24e-8 Diastolic blood pressure; CESC cis rs3091242 0.933 rs9438905 chr1:25764177 A/G cg02931644 chr1:25747376 RHCE 0.4 6.65 0.38 1.64e-10 Erythrocyte sedimentation rate; CESC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg10691866 chr7:65817282 TPST1 0.33 5.69 0.33 3.43e-8 Aortic root size; CESC cis rs113835537 0.597 rs2075792 chr11:66334556 G/A cg22134325 chr11:66188745 NPAS4 0.37 5.53 0.32 7.86e-8 Airway imaging phenotypes; CESC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.4 -0.37 7.06e-10 Life satisfaction; CESC cis rs9929218 0.861 rs8056206 chr16:68802072 G/C cg02972257 chr16:68554789 NA 0.44 5.33 0.31 2.11e-7 Colorectal cancer; CESC cis rs9287719 0.649 rs12473957 chr2:10717714 C/G cg00105475 chr2:10696890 NA -0.37 -5.2 -0.3 3.99e-7 Prostate cancer; CESC cis rs2070997 0.607 rs2772028 chr9:133707940 C/T cg11464064 chr9:133710261 ABL1 0.68 7.64 0.42 4.03e-13 Response to amphetamines; CESC cis rs854765 0.654 rs9911281 chr17:17762457 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.43 -5.68 -0.33 3.55e-8 Total body bone mineral density; CESC cis rs17376456 0.778 rs72786662 chr5:93137630 C/T cg25358565 chr5:93447407 FAM172A 1.15 10.72 0.55 1.63e-22 Diabetic retinopathy; CESC cis rs922182 0.692 rs7162147 chr15:64291500 G/A cg24729988 chr15:64271149 DAPK2 0.39 5.5 0.32 9.06e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06346138 chr1:17086071 MST1P9 -0.53 -6.23 -0.36 1.79e-9 Gut microbiome composition (summer); CESC cis rs2204008 0.777 rs114096617 chr12:38342557 A/C cg13010199 chr12:38710504 ALG10B 0.48 6.05 0.35 4.92e-9 Bladder cancer; CESC cis rs2070488 0.775 rs2051214 chr3:38560303 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.76 -11.47 -0.58 5.3e-25 Electrocardiographic conduction measures; CESC cis rs1348850 0.632 rs1405718 chr2:178499809 C/T cg22681709 chr2:178499509 PDE11A -0.57 -9.17 -0.49 1.4e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7824557 0.736 rs10107010 chr8:11132712 C/A cg21775007 chr8:11205619 TDH -0.47 -7.04 -0.4 1.65e-11 Retinal vascular caliber; CESC cis rs6665290 0.901 rs11580229 chr1:227210820 G/A cg10327440 chr1:227177885 CDC42BPA -1.14 -23.42 -0.82 1.69e-66 Myeloid white cell count; CESC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg02725872 chr8:58115012 NA -0.42 -5.72 -0.33 2.88e-8 Developmental language disorder (linguistic errors); CESC trans rs61931739 0.817 rs10743841 chr12:34252870 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.63 0.38 1.84e-10 Morning vs. evening chronotype; CESC cis rs8180040 0.629 rs7426969 chr3:47091355 T/C cg27129171 chr3:47204927 SETD2 0.67 9.83 0.52 1.18e-19 Colorectal cancer; CESC cis rs787274 0.850 rs4979176 chr9:115641181 A/G cg13803584 chr9:115635662 SNX30 0.64 5.36 0.31 1.79e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs2735413 0.918 rs4887932 chr16:78078350 C/A cg04733911 chr16:78082701 NA -0.53 -8.92 -0.48 7.6e-17 Systolic blood pressure (alcohol consumption interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12012699 chr18:46986876 DYM -0.58 -6.72 -0.38 1.13e-10 Gut microbiome composition (summer); CESC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg07701084 chr6:150067640 NUP43 0.47 6.58 0.37 2.51e-10 Lung cancer; CESC cis rs59918340 0.692 rs6983780 chr8:142231944 G/A cg16341495 chr8:142228727 SLC45A4 -0.44 -5.29 -0.31 2.54e-7 Immature fraction of reticulocytes; CESC cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg06219351 chr7:158114137 PTPRN2 -0.5 -7.7 -0.43 2.69e-13 Calcium levels; CESC trans rs9388451 0.626 rs2875881 chr6:126072853 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.66 -9.27 -0.49 6.69e-18 Brugada syndrome; CESC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg03188948 chr7:1209495 NA 0.61 6.91 0.39 3.61e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 6.2e-30 Colonoscopy-negative controls vs population controls; CESC cis rs7647973 1.000 rs7644148 chr3:49545241 G/A cg02487422 chr3:49467188 NICN1 -0.41 -5.36 -0.31 1.81e-7 Menarche (age at onset); CESC cis rs752010 0.619 rs6703992 chr1:42115888 G/A cg06885757 chr1:42089581 HIVEP3 0.62 9.63 0.51 5.16e-19 Lupus nephritis in systemic lupus erythematosus; CESC trans rs916888 0.773 rs199439 chr17:44793503 A/G cg10053473 chr17:62856997 LRRC37A3 -0.7 -7.58 -0.42 5.96e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs6968419 0.788 rs1317791 chr7:115839721 C/G cg02561103 chr7:115862891 TES -0.39 -5.22 -0.31 3.62e-7 Intraocular pressure; CESC cis rs3741151 1.000 rs74776668 chr11:73065909 G/A cg17517138 chr11:73019481 ARHGEF17 1.05 7.11 0.4 1.09e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CESC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg16145915 chr7:1198662 ZFAND2A -0.46 -6.41 -0.37 6.59e-10 Longevity;Endometriosis; CESC cis rs1707322 0.721 rs6429574 chr1:46134054 A/G cg03146154 chr1:46216737 IPP 0.76 10.71 0.55 1.81e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs60154123 0.505 rs115881613 chr1:210040369 C/T cg21951975 chr1:209979733 IRF6 0.58 6.23 0.36 1.85e-9 Coronary artery disease; CESC cis rs3892630 0.588 rs7245709 chr19:33242755 C/T cg22980127 chr19:33182716 NUDT19 1.13 14.4 0.66 4.03e-35 Red blood cell traits; CESC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg04369109 chr6:150039330 LATS1 -0.36 -5.03 -0.3 9.18e-7 Lung cancer; CESC cis rs916888 0.773 rs199445 chr17:44817408 C/T cg15921436 chr17:44337874 NA 0.75 8.25 0.45 7.37e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs12824058 0.831 rs11060825 chr12:130807905 A/G cg26677194 chr12:130822605 PIWIL1 0.5 6.55 0.37 2.96e-10 Menopause (age at onset); CESC cis rs7224314 1.000 rs62085810 chr17:65372855 G/A cg01507342 chr17:65387096 PITPNC1 -0.46 -5.27 -0.31 2.86e-7 Diisocyanate-induced asthma; CESC cis rs593982 1.000 rs74638829 chr11:65495571 C/T cg08755490 chr11:65554678 OVOL1 -1.26 -10.56 -0.54 5.65e-22 Atopic dermatitis; CESC cis rs34658409 1 rs34658409 chr8:42433985 TC/T cg09913449 chr8:42400586 C8orf40 0.43 7.15 0.4 8.32e-12 Mean corpuscular hemoglobin concentration; CESC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg14393609 chr7:65229607 NA 0.47 6.31 0.36 1.17e-9 Aortic root size; CESC cis rs950027 0.620 rs1153860 chr15:45636584 A/G cg21132104 chr15:45694354 SPATA5L1 -0.65 -8.27 -0.45 6.68e-15 Response to fenofibrate (adiponectin levels); CESC cis rs4909189 1.000 rs62493651 chr7:158135592 T/C cg06219351 chr7:158114137 PTPRN2 -0.6 -8.1 -0.45 2e-14 Response to amphetamines; CESC cis rs6867032 1.000 rs16902321 chr5:2015148 A/G cg26168224 chr5:2018326 NA 0.96 20.64 0.79 4.27e-57 Gut microbiome composition (winter); CESC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg22800045 chr5:56110881 MAP3K1 0.82 10.29 0.53 4.07e-21 Initial pursuit acceleration; CESC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -6.2 -0.36 2.15e-9 Glomerular filtration rate in chronic kidney disease; CESC cis rs911555 0.755 rs11627446 chr14:103946450 G/C cg12935359 chr14:103987150 CKB -0.59 -8.46 -0.46 1.8e-15 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23429981 chr6:97345948 NDUFAF4 0.54 6.09 0.35 3.89e-9 Gut microbiome composition (summer); CESC cis rs6598955 0.670 rs10902734 chr1:26617923 G/T cg00852783 chr1:26633632 UBXN11 -0.42 -6.03 -0.35 5.35e-9 Obesity-related traits; CESC cis rs6964587 0.839 rs6950538 chr7:91417816 T/C cg17063962 chr7:91808500 NA 0.48 6.21 0.36 2.03e-9 Breast cancer; CESC cis rs62103177 0.608 rs8088089 chr18:77832154 A/G cg12964065 chr18:77638022 KCNG2 -0.45 -5.14 -0.3 5.26e-7 Opioid sensitivity; CESC cis rs4835473 0.900 rs13119630 chr4:144695054 T/G cg25736465 chr4:144833511 NA -0.33 -5.18 -0.3 4.39e-7 Immature fraction of reticulocytes; CESC cis rs1707322 1.000 rs10789486 chr1:46408667 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.49 0.32 9.37e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg08470875 chr2:26401718 FAM59B -0.48 -5.27 -0.31 2.79e-7 Gut microbiome composition (summer); CESC cis rs6460942 0.915 rs75158182 chr7:12456059 C/T cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs7605827 0.930 rs2058869 chr2:15679700 T/C cg19274914 chr2:15703543 NA 0.37 6.7 0.38 1.22e-10 Educational attainment (years of education); CESC cis rs11997175 0.572 rs7836230 chr8:33623250 T/C ch.8.33884649F chr8:33765107 NA 0.57 7.35 0.41 2.5e-12 Body mass index; CESC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg03354898 chr7:1950403 MAD1L1 -0.31 -5.18 -0.3 4.49e-7 Bipolar disorder and schizophrenia; CESC cis rs2963155 0.518 rs6196 chr5:142661490 A/G cg17617527 chr5:142782415 NR3C1 0.76 7.08 0.4 1.28e-11 Breast cancer; CESC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg18876405 chr7:65276391 NA -0.53 -7.19 -0.4 6.46e-12 Aortic root size; CESC cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg06544989 chr22:39130855 UNC84B 0.5 8.88 0.48 1.05e-16 Menopause (age at onset); CESC cis rs2985684 0.894 rs6572586 chr14:50021941 A/C cg04989706 chr14:50066350 PPIL5 -0.45 -5.21 -0.3 3.81e-7 Carotid intima media thickness; CESC cis rs72945132 0.882 rs7123602 chr11:70181489 C/T cg00319359 chr11:70116639 PPFIA1 0.74 7.17 0.4 7.55e-12 Coronary artery disease; CESC trans rs921968 0.541 rs523305 chr2:219402691 T/C cg15547669 chr20:2781122 CPXM1 0.35 6.0 0.35 6.31e-9 Mean corpuscular hemoglobin concentration; CESC cis rs10504073 0.647 rs62507245 chr8:50006939 A/T cg00325661 chr8:49890786 NA 0.57 8.45 0.46 1.97e-15 Blood metabolite ratios; CESC cis rs933688 1.000 rs6452951 chr5:90653868 T/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.13 14.96 0.68 4.21e-37 Smoking behavior; CESC cis rs7131987 0.834 rs7139273 chr12:29434650 T/C cg09582351 chr12:29534625 ERGIC2 -0.31 -5.1 -0.3 6.42e-7 QT interval; CESC cis rs2963155 0.518 rs258748 chr5:142656454 C/G cg17617527 chr5:142782415 NR3C1 0.83 7.48 0.42 1.1e-12 Breast cancer; CESC trans rs7618501 0.602 rs2245365 chr3:50097319 C/A cg21659725 chr3:3221576 CRBN -0.53 -7.42 -0.41 1.59e-12 Intelligence (multi-trait analysis); CESC cis rs2439831 0.867 rs12323999 chr15:43683115 T/A cg27015174 chr15:43622946 ADAL;LCMT2 0.91 11.03 0.56 1.59e-23 Lung cancer in ever smokers; CESC cis rs7772486 0.875 rs1929523 chr6:146339989 T/A cg23711669 chr6:146136114 FBXO30 0.86 12.53 0.61 1.39e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs2439831 0.867 rs11856184 chr15:43919162 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.81 8.35 0.46 3.84e-15 Lung cancer in ever smokers; CESC cis rs10851478 0.872 rs12901680 chr15:49880905 T/C cg08060515 chr15:49448048 GALK2;COPS2 0.43 5.24 0.31 3.24e-7 Oral cavity cancer; CESC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg26354017 chr1:205819088 PM20D1 0.93 16.28 0.71 8.56e-42 Menarche (age at onset); CESC cis rs2073300 0.609 rs6132615 chr20:23413200 T/C cg12062639 chr20:23401060 NAPB 1.06 8.19 0.45 1.14e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs35110281 0.641 rs4818861 chr21:45123807 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -8.3 -0.45 5.49e-15 Mean corpuscular volume; CESC cis rs2832077 0.527 rs2705690 chr21:30239245 T/A cg08807101 chr21:30365312 RNF160 0.53 6.45 0.37 5.32e-10 Cognitive test performance; CESC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.14e-8 Major depressive disorder; CESC cis rs2180341 1.000 rs7453272 chr6:127633959 C/T cg27446573 chr6:127587934 RNF146 -0.97 -12.78 -0.62 1.79e-29 Breast cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04319218 chr19:11307663 KANK2 -0.43 -6.17 -0.35 2.52e-9 Fibrinogen levels; CESC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg21724239 chr8:58056113 NA 0.57 5.76 0.33 2.29e-8 Developmental language disorder (linguistic errors); CESC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg06481639 chr22:41940642 POLR3H -0.64 -6.64 -0.38 1.78e-10 Vitiligo; CESC cis rs7772486 0.875 rs6930975 chr6:146387111 C/T cg23711669 chr6:146136114 FBXO30 0.79 11.75 0.59 6.03e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs73001065 0.818 rs58847337 chr19:19726022 G/A cg03709012 chr19:19516395 GATAD2A 0.95 6.37 0.36 8.22e-10 LDL cholesterol; CESC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg22920501 chr2:26401640 FAM59B 0.91 10.34 0.54 2.94e-21 Gut microbiome composition (summer); CESC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg04166393 chr7:2884313 GNA12 0.63 8.13 0.45 1.71e-14 Height; CESC cis rs9303280 0.806 rs8069176 chr17:38057197 G/A cg20243544 chr17:37824526 PNMT 0.49 6.28 0.36 1.37e-9 Self-reported allergy; CESC cis rs2072732 0.768 rs57893585 chr1:2944671 T/A cg03976712 chr1:2946727 NA 0.34 5.35 0.31 1.9e-7 Plateletcrit; CESC cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg03467027 chr4:99064603 C4orf37 0.47 5.96 0.34 8.08e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9815354 1.000 rs1716987 chr3:41970516 A/G cg03022575 chr3:42003672 ULK4 -0.46 -5.37 -0.31 1.74e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs1538970 0.816 rs11211123 chr1:45957609 G/A cg05343316 chr1:45956843 TESK2 0.93 12.78 0.62 1.91e-29 Platelet count; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg21063480 chr14:78082891 SPTLC2 0.47 6.0 0.35 6.41e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6752107 1.000 rs3792112 chr2:234176609 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 6.76 0.38 8.81e-11 Crohn's disease;Inflammatory bowel disease; CESC cis rs7089973 0.872 rs7094072 chr10:116627160 T/G cg23260525 chr10:116636907 FAM160B1 0.38 6.42 0.37 6.35e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg19163074 chr7:65112434 INTS4L2 0.52 5.35 0.31 1.87e-7 Aortic root size; CESC cis rs2637266 1.000 rs7475686 chr10:78358761 T/C cg18941641 chr10:78392320 NA 0.42 7.91 0.44 7.15e-14 Pulmonary function; CESC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg26335602 chr6:28129616 ZNF389 0.44 5.7 0.33 3.25e-8 Parkinson's disease; CESC cis rs642803 1.000 rs557675 chr11:65566719 G/T cg02870584 chr11:65547924 DKFZp761E198 -0.41 -5.14 -0.3 5.26e-7 Urate levels; CESC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg22920501 chr2:26401640 FAM59B -0.79 -9.3 -0.5 5.61e-18 Gut microbiome composition (summer); CESC cis rs67311347 0.955 rs2085114 chr3:40497437 T/A cg09455208 chr3:40491958 NA 0.5 7.92 0.44 6.41e-14 Renal cell carcinoma; CESC cis rs12618769 0.601 rs56118505 chr2:99139832 T/G cg10123293 chr2:99228465 UNC50 0.38 5.04 0.3 8.64e-7 Bipolar disorder; CESC cis rs4808199 0.895 rs10421505 chr19:19459554 C/T cg03709012 chr19:19516395 GATAD2A 1.07 12.42 0.61 3.25e-28 Nonalcoholic fatty liver disease; CESC cis rs873946 0.586 rs12767391 chr10:134573844 A/G cg27286337 chr10:134555280 INPP5A -0.67 -7.9 -0.44 7.49e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs6831352 0.918 rs2851253 chr4:100043505 G/T cg13256891 chr4:100009986 ADH5 -0.74 -8.47 -0.46 1.71e-15 Alcohol dependence; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05992875 chr8:144621330 ZC3H3 0.49 6.4 0.37 6.89e-10 Fibrinogen levels; CESC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg26314531 chr2:26401878 FAM59B 0.81 8.44 0.46 2.06e-15 Gut microbiome composition (summer); CESC cis rs9911578 1.000 rs11870671 chr17:56605360 A/G cg12560992 chr17:57184187 TRIM37 -0.93 -15.59 -0.69 2.43e-39 Intelligence (multi-trait analysis); CESC cis rs651907 0.535 rs11717638 chr3:101505468 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 6.1 0.35 3.71e-9 Colorectal cancer; CESC cis rs62103177 0.733 rs62096747 chr18:77619568 A/G cg12964065 chr18:77638022 KCNG2 0.58 5.68 0.33 3.5e-8 Opioid sensitivity; CESC cis rs977987 0.806 rs8050059 chr16:75388731 C/T cg03315344 chr16:75512273 CHST6 0.4 5.78 0.33 2.05e-8 Dupuytren's disease; CESC cis rs10751667 0.961 rs7943115 chr11:973885 T/C cg20946044 chr11:1010712 AP2A2 -0.42 -5.63 -0.33 4.63e-8 Alzheimer's disease (late onset); CESC cis rs9796 0.870 rs2925346 chr15:41315695 G/A cg18705301 chr15:41695430 NDUFAF1 0.42 6.32 0.36 1.13e-9 Menopause (age at onset); CESC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg08392591 chr16:89556376 ANKRD11 0.41 5.32 0.31 2.26e-7 Multiple myeloma (IgH translocation); CESC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg23161317 chr6:28129485 ZNF389 0.52 6.66 0.38 1.59e-10 Depression; CESC cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg17366294 chr4:99064904 C4orf37 0.61 8.76 0.47 2.35e-16 Colonoscopy-negative controls vs population controls; CESC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg21784768 chr11:537496 LRRC56 -0.57 -5.36 -0.31 1.85e-7 Body mass index; CESC cis rs7188697 0.922 rs37061 chr16:58566671 A/G cg02549819 chr16:58548995 SETD6 -0.42 -5.25 -0.31 3.1e-7 QT interval; CESC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.7 -0.33 3.25e-8 Total body bone mineral density; CESC cis rs4604732 0.631 rs12031694 chr1:247623653 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.39 0.31 1.53e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7692995 0.920 rs16896155 chr4:17962935 A/T cg08925142 chr4:18023851 LCORL -0.45 -5.13 -0.3 5.66e-7 Height; CESC cis rs34779708 0.931 rs12268745 chr10:35305989 C/G cg03585969 chr10:35415529 CREM 0.75 10.02 0.52 2.93e-20 Inflammatory bowel disease;Crohn's disease; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg05221349 chr4:100870488 LOC256880;H2AFZ 0.43 6.48 0.37 4.37e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.64 8.09 0.44 2.22e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg17949981 chr6:28129498 ZNF389 0.45 5.49 0.32 9.35e-8 Depression; CESC cis rs7267979 1.000 rs4813562 chr20:25352588 G/A cg08601574 chr20:25228251 PYGB -0.38 -5.55 -0.32 6.88e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2658782 0.526 rs3020062 chr11:93061159 T/C cg15737290 chr11:93063684 CCDC67 0.55 7.61 0.42 4.71e-13 Pulmonary function decline; CESC cis rs3806843 0.676 rs2245643 chr5:140029780 C/T cg16179182 chr5:140090404 VTRNA1-1 0.43 5.68 0.33 3.48e-8 Depressive symptoms (multi-trait analysis); CESC cis rs9354308 0.901 rs55832318 chr6:66560086 A/G cg07460842 chr6:66804631 NA 0.67 7.56 0.42 6.51e-13 Metabolite levels; CESC cis rs6688613 0.685 rs4657613 chr1:166870878 A/G cg07049167 chr1:166818506 POGK 0.45 5.38 0.31 1.61e-7 Refractive astigmatism; CESC cis rs7089973 0.872 rs41284358 chr10:116622339 A/G cg23260525 chr10:116636907 FAM160B1 0.38 6.42 0.37 6.35e-10 Bipolar disorder or attention deficit hyperactivity disorder; CESC trans rs10074525 0.885 rs34381536 chr5:90257392 A/G cg22855255 chr17:50237267 CA10 -0.37 -6.38 -0.36 7.97e-10 Obesity-related traits; CESC cis rs4237845 0.586 rs4760174 chr12:58320436 G/A cg00677455 chr12:58241039 CTDSP2 0.43 5.4 0.31 1.47e-7 Intelligence (multi-trait analysis); CESC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.52 7.13 0.4 9.29e-12 Lymphocyte counts; CESC cis rs2296225 0.722 rs12403580 chr1:21049518 C/T cg24673385 chr1:21051448 SH2D5 0.33 5.28 0.31 2.72e-7 Eosinophilic esophagitis; CESC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.47e-7 Life satisfaction; CESC cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg18180107 chr4:99064573 C4orf37 0.39 5.07 0.3 7.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7847628 0.587 rs1060817 chr9:123583192 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.94 17.46 0.73 5.92e-46 Birth weight; CESC cis rs3096299 0.606 rs2965946 chr16:89516612 T/C cg08392591 chr16:89556376 ANKRD11 0.44 5.22 0.31 3.64e-7 Multiple myeloma (IgH translocation); CESC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg19046167 chr17:80928561 B3GNTL1 0.4 5.03 0.3 9.23e-7 Breast cancer; CESC cis rs4332037 0.664 rs73046334 chr7:1887037 T/C cg13880726 chr7:1868755 MAD1L1 -0.49 -5.16 -0.3 4.83e-7 Bipolar disorder; CESC cis rs9399137 0.507 rs7748708 chr6:135275142 G/A cg24558204 chr6:135376177 HBS1L 0.72 9.68 0.51 3.5e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CESC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.83 8.82 0.48 1.58e-16 Platelet count; CESC cis rs9399135 0.967 rs6923765 chr6:135335176 C/G cg22676075 chr6:135203613 NA -0.5 -7.06 -0.4 1.44e-11 Red blood cell count; CESC cis rs4664293 1.000 rs13014418 chr2:160483685 T/G cg08347373 chr2:160653686 CD302 -0.32 -5.08 -0.3 7.08e-7 Monocyte percentage of white cells; CESC cis rs9612 1.000 rs2074634 chr19:44238347 C/T cg08581076 chr19:44259116 C19orf61 -0.53 -6.12 -0.35 3.3e-9 Exhaled nitric oxide output; CESC cis rs9488822 0.676 rs12154016 chr6:116355188 C/T cg18764771 chr6:116381957 FRK 0.22 5.59 0.32 5.54e-8 Cholesterol, total;LDL cholesterol; CESC cis rs11190604 1.000 rs1417823 chr10:102227886 C/T cg07080220 chr10:102295463 HIF1AN -0.5 -5.16 -0.3 4.94e-7 Palmitoleic acid (16:1n-7) levels; CESC cis rs2204008 0.749 rs10880692 chr12:38592918 C/G cg13010199 chr12:38710504 ALG10B -0.54 -6.96 -0.39 2.66e-11 Bladder cancer; CESC cis rs1707322 1.000 rs7547284 chr1:46319565 C/G cg06784218 chr1:46089804 CCDC17 0.32 5.57 0.32 6.35e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7833790 0.676 rs7834555 chr8:82697625 A/G cg07697082 chr8:82753677 SNX16 0.36 5.54 0.32 7.16e-8 Diastolic blood pressure; CESC trans rs13360092 0.881 rs9291724 chr5:50561870 A/G cg03200537 chr16:87022121 NA 0.69 6.01 0.35 6.15e-9 Verbal declarative memory; CESC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg11764359 chr7:65958608 NA 0.71 9.39 0.5 2.85e-18 Aortic root size; CESC cis rs4835473 0.932 rs4092718 chr4:144720790 A/G cg25736465 chr4:144833511 NA -0.42 -6.36 -0.36 9.01e-10 Immature fraction of reticulocytes; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg21012729 chr14:51297401 NIN -0.4 -6.08 -0.35 4.09e-9 Gambling; CESC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg00684032 chr4:1343700 KIAA1530 0.42 5.93 0.34 9.41e-9 Obesity-related traits; CESC cis rs79349575 0.783 rs12602933 chr17:47029280 G/C cg26022315 chr17:47021804 SNF8 0.39 5.16 0.3 4.94e-7 Type 2 diabetes; CESC cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg20503657 chr10:835505 NA 0.74 7.57 0.42 6.23e-13 Eosinophil percentage of granulocytes; CESC cis rs2486288 0.656 rs6493144 chr15:45573489 C/G cg21132104 chr15:45694354 SPATA5L1 0.59 7.19 0.4 6.61e-12 Glomerular filtration rate; CESC cis rs709400 0.832 rs55864158 chr14:104068579 G/A cg12935359 chr14:103987150 CKB -0.47 -5.98 -0.34 7.27e-9 Body mass index; CESC cis rs5769765 0.955 rs9616366 chr22:50301178 C/T cg26441486 chr22:50317300 CRELD2 0.4 5.38 0.31 1.6e-7 Schizophrenia; CESC cis rs9815354 0.767 rs60943892 chr3:41852307 T/C cg03022575 chr3:42003672 ULK4 0.71 6.36 0.36 8.91e-10 Pulse pressure;Diastolic blood pressure; CESC trans rs7839040 0.698 rs13262552 chr8:82932653 T/C cg14472086 chr9:107730925 NA -0.48 -6.45 -0.37 5.4e-10 Response to methotrexate in juvenile idiopathic arthritis; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg09410845 chr2:203241870 BMPR2 0.52 6.85 0.39 5.04e-11 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg11952622 chr19:58962976 ZNF324B 0.46 6.14 0.35 3.06e-9 Uric acid clearance; CESC cis rs4132509 1.000 rs12049228 chr1:243995271 C/A cg21452805 chr1:244014465 NA 0.5 6.17 0.35 2.52e-9 RR interval (heart rate); CESC cis rs10924970 0.625 rs3806394 chr1:235489850 C/T cg26050004 chr1:235667680 B3GALNT2 0.44 5.09 0.3 6.77e-7 Asthma; CESC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.9 -13.26 -0.63 4.07e-31 Alzheimer's disease; CESC cis rs2011503 0.941 rs56278919 chr19:19367190 A/G cg11584989 chr19:19387371 SF4 0.63 7.52 0.42 8.34e-13 Bipolar disorder; CESC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.34 -5.57 -0.32 6.1e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs2404602 0.692 rs4886829 chr15:77091182 G/T cg26408565 chr15:76604113 ETFA -0.38 -5.54 -0.32 7.27e-8 Blood metabolite levels; CESC cis rs3857536 0.740 rs7751095 chr6:66891318 A/G cg07460842 chr6:66804631 NA -0.4 -5.23 -0.31 3.47e-7 Blood trace element (Cu levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03195600 chr16:11350371 SOCS1 0.55 6.41 0.37 6.7e-10 Gut microbiome composition (summer); CESC cis rs36051895 0.589 rs7038763 chr9:5076399 T/C cg02405213 chr9:5042618 JAK2 -0.49 -6.07 -0.35 4.35e-9 Pediatric autoimmune diseases; CESC cis rs763121 0.889 rs1043402 chr22:38879688 G/A cg06022373 chr22:39101656 GTPBP1 0.8 11.31 0.57 1.87e-24 Menopause (age at onset); CESC cis rs4595586 0.545 rs3858554 chr12:39381460 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs2243480 0.803 rs35268390 chr7:65416536 C/G cg13147721 chr7:65941812 NA -0.86 -8.49 -0.46 1.47e-15 Diabetic kidney disease; CESC cis rs7395581 0.959 rs7129661 chr11:47268550 T/G cg25783544 chr11:47291846 MADD 0.59 7.73 0.43 2.22e-13 HDL cholesterol; CESC cis rs6060717 0.536 rs6058364 chr20:34507890 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.65 5.61 0.33 4.97e-8 Hip circumference adjusted for BMI; CESC cis rs7100689 0.784 rs3802638 chr10:82179689 T/C cg00277334 chr10:82204260 NA -0.61 -7.42 -0.41 1.57e-12 Post bronchodilator FEV1; CESC trans rs1814175 0.645 rs28634872 chr11:50042175 T/A cg03929089 chr4:120376271 NA -0.91 -14.82 -0.67 1.29e-36 Height; CESC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -5.84 -0.34 1.49e-8 Parkinson's disease; CESC cis rs763014 0.865 rs710924 chr16:633353 T/C cg09263875 chr16:632152 PIGQ 0.67 11.24 0.57 3.15e-24 Height; CESC cis rs244293 0.730 rs12165058 chr17:53022049 T/C cg19360675 chr17:53046073 COX11;STXBP4 -0.44 -5.85 -0.34 1.48e-8 Menarche (age at onset); CESC cis rs3857536 0.813 rs7757118 chr6:66946661 T/C cg07460842 chr6:66804631 NA -0.42 -5.29 -0.31 2.55e-7 Blood trace element (Cu levels); CESC cis rs9457247 1.000 rs2769347 chr6:167371737 T/A cg23791538 chr6:167370224 RNASET2 0.59 8.47 0.46 1.75e-15 Crohn's disease; CESC cis rs959260 1.000 rs7226070 chr17:73372811 T/C cg12999837 chr17:73267436 MIF4GD -0.47 -5.5 -0.32 8.8e-8 Systemic lupus erythematosus; CESC cis rs9926296 0.744 rs164746 chr16:89709019 C/T cg03605463 chr16:89740564 NA 0.57 6.51 0.37 3.67e-10 Vitiligo; CESC cis rs2273669 0.667 rs12205053 chr6:109338110 T/C cg05315195 chr6:109294784 ARMC2 -0.67 -6.32 -0.36 1.13e-9 Prostate cancer; CESC cis rs67311347 1.000 rs11714912 chr3:40494065 A/G cg24209194 chr3:40518798 ZNF619 -0.47 -6.28 -0.36 1.4e-9 Renal cell carcinoma; CESC trans rs3780486 0.505 rs959749 chr9:33147858 T/C cg04842962 chr6:43655489 MRPS18A 0.68 10.27 0.53 4.66e-21 IgG glycosylation; CESC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg13206674 chr6:150067644 NUP43 0.39 5.55 0.32 7.04e-8 Lung cancer; CESC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg18446336 chr7:2847575 GNA12 0.33 5.32 0.31 2.24e-7 Height; CESC cis rs7216064 0.773 rs74541577 chr17:65853651 C/T cg12091567 chr17:66097778 LOC651250 -0.85 -8.71 -0.47 3.45e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs12681366 0.537 rs9297939 chr8:95480189 A/C cg13257157 chr8:95487014 RAD54B 0.45 5.47 0.32 1.05e-7 Nonsyndromic cleft lip with cleft palate; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12759597 chr1:155181615 MTX1 -0.61 -7.22 -0.41 5.56e-12 Gut microbiome composition (summer); CESC cis rs7617773 0.539 rs17593974 chr3:48387334 G/T cg11946769 chr3:48343235 NME6 0.65 8.35 0.46 3.86e-15 Coronary artery disease; CESC cis rs2294693 0.945 rs11756893 chr6:41010058 A/C cg14769373 chr6:40998127 UNC5CL -0.45 -5.78 -0.33 2.09e-8 Gastric cancer;Non-cardia gastric cancer; CESC cis rs1580019 0.922 rs1466147 chr7:32486262 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.88 12.35 0.6 5.7e-28 Cognitive ability; CESC cis rs17376456 0.569 rs10050364 chr5:93064127 T/C cg25358565 chr5:93447407 FAM172A 0.67 7.24 0.41 4.81e-12 Diabetic retinopathy; CESC cis rs8180040 0.620 rs11707736 chr3:47069504 G/T cg27129171 chr3:47204927 SETD2 -0.67 -9.93 -0.52 5.93e-20 Colorectal cancer; CESC cis rs4718428 0.705 rs12536410 chr7:66254290 G/A cg18252515 chr7:66147081 NA -0.46 -5.1 -0.3 6.63e-7 Corneal structure; CESC cis rs10979 0.965 rs9403508 chr6:143887857 G/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.14 -0.49 1.72e-17 Hypospadias; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06955158 chr5:10249878 FAM173B;CCT5 0.69 8.3 0.45 5.4e-15 Gut microbiome composition (summer); CESC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg22535103 chr8:58192502 C8orf71 -0.93 -10.31 -0.53 3.63e-21 Developmental language disorder (linguistic errors); CESC cis rs8067545 0.604 rs55705283 chr17:20027138 G/A cg13482628 chr17:19912719 NA 0.39 5.23 0.31 3.45e-7 Schizophrenia; CESC cis rs2243480 1.000 rs6964530 chr7:65718851 G/C cg18252515 chr7:66147081 NA 1.39 14.1 0.65 4.44e-34 Diabetic kidney disease; CESC cis rs8072100 0.840 rs1912482 chr17:45454883 G/A cg08085267 chr17:45401833 C17orf57 -0.54 -7.22 -0.41 5.38e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CESC trans rs11098499 0.954 rs6848389 chr4:120402622 A/G cg25214090 chr10:38739885 LOC399744 0.68 9.28 0.5 6.19e-18 Corneal astigmatism; CESC cis rs9660992 0.710 rs55671824 chr1:205249814 G/A cg21643547 chr1:205240462 TMCC2 -0.46 -6.16 -0.35 2.67e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs7520050 0.933 rs12565042 chr1:46299110 C/A cg03146154 chr1:46216737 IPP -0.48 -6.36 -0.36 8.91e-10 Red blood cell count;Reticulocyte count; CESC cis rs72781680 0.800 rs56398785 chr2:24091515 T/A cg20701182 chr2:24300061 SF3B14 0.78 6.91 0.39 3.59e-11 Lymphocyte counts; CESC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg11133979 chr8:110548574 NA 0.41 6.39 0.37 7.35e-10 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.39 0.31 1.54e-7 Bipolar disorder; CESC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg22823121 chr1:150693482 HORMAD1 0.38 5.58 0.32 5.92e-8 Tonsillectomy; CESC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg07677032 chr17:61819896 STRADA 0.43 5.42 0.32 1.35e-7 Height; CESC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg13628971 chr7:2884303 GNA12 0.65 8.39 0.46 2.85e-15 Height; CESC cis rs754466 1.000 rs12220311 chr10:79681507 C/T cg17075019 chr10:79541650 NA -0.76 -9.61 -0.51 5.75e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg24642844 chr7:1081250 C7orf50 -0.65 -8.68 -0.47 4.11e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg14262678 chr6:151773367 RMND1;C6orf211 0.63 8.85 0.48 1.23e-16 Menarche (age at onset); CESC cis rs2070677 0.935 rs4300354 chr10:135415890 C/T cg20169779 chr10:135381914 SYCE1 -0.74 -9.71 -0.51 2.99e-19 Gout; CESC cis rs6752107 1.000 rs13009506 chr2:234175706 A/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.46 -6.2 -0.36 2.13e-9 Crohn's disease;Inflammatory bowel disease; CESC cis rs9911578 0.765 rs66954617 chr17:56999427 A/G cg12560992 chr17:57184187 TRIM37 0.93 15.49 0.69 5.42e-39 Intelligence (multi-trait analysis); CESC cis rs4919087 0.923 rs12357266 chr10:98978045 G/A cg25902810 chr10:99078978 FRAT1 0.72 10.45 0.54 1.25e-21 Monocyte count; CESC cis rs7605827 0.930 rs6761904 chr2:15599658 A/G cg19274914 chr2:15703543 NA 0.34 6.1 0.35 3.79e-9 Educational attainment (years of education); CESC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.38 -6.14 -0.35 2.97e-9 Cystic fibrosis severity; CESC cis rs10857712 0.754 rs7921041 chr10:135229239 G/C cg01444801 chr10:135216882 MTG1 -0.44 -5.23 -0.31 3.53e-7 Systemic lupus erythematosus; CESC cis rs9859260 0.555 rs9877493 chr3:195832147 T/C cg12923728 chr3:195709715 SDHAP1 -0.5 -5.91 -0.34 1.05e-8 Mean corpuscular volume; CESC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg26335602 chr6:28129616 ZNF389 0.44 5.61 0.33 5.19e-8 Parkinson's disease; CESC cis rs4253772 0.550 rs11703564 chr22:46722194 G/A cg24881330 chr22:46731750 TRMU 0.78 5.94 0.34 8.8e-9 LDL cholesterol;Cholesterol, total; CESC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.37 -0.36 8.42e-10 Developmental language disorder (linguistic errors); CESC cis rs1465370 0.750 rs3807136 chr7:130019481 C/T cg04743876 chr7:130013617 NA 0.31 5.93 0.34 9.5e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CESC trans rs7628583 0.628 rs79157151 chr3:64073123 C/T cg07702853 chr1:150254280 C1orf51 -0.55 -6.0 -0.35 6.46e-9 Parental extreme longevity (95 years and older); CESC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg04317338 chr11:64019027 PLCB3 0.9 9.42 0.5 2.3e-18 Mean platelet volume; CESC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg19468946 chr17:37922297 IKZF3 -0.39 -5.03 -0.3 8.96e-7 Glomerular filtration rate (creatinine); CESC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.43e-7 Life satisfaction; CESC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg14159672 chr1:205819179 PM20D1 0.5 6.59 0.38 2.43e-10 Menarche (age at onset); CESC trans rs2018683 0.739 rs10233884 chr7:28972307 A/G cg19402173 chr7:128379420 CALU -0.51 -6.77 -0.38 8.38e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs9549260 0.755 rs4943800 chr13:41216831 A/G cg21288729 chr13:41239152 FOXO1 0.67 8.77 0.47 2.28e-16 Red blood cell count; CESC cis rs9815354 0.812 rs73081361 chr3:41912535 G/A cg03022575 chr3:42003672 ULK4 0.7 6.18 0.36 2.38e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs12142240 0.698 rs41294456 chr1:46809782 T/C cg10495392 chr1:46806563 NSUN4 0.59 6.34 0.36 9.65e-10 Menopause (age at onset); CESC trans rs11098499 0.731 rs9995026 chr4:120490499 T/A cg25214090 chr10:38739885 LOC399744 0.64 8.69 0.47 3.86e-16 Corneal astigmatism; CESC cis rs4699052 1.000 rs7661702 chr4:104140129 C/G cg16532752 chr4:104119610 CENPE -0.41 -5.55 -0.32 6.98e-8 Testicular germ cell tumor; CESC cis rs1670533 1.000 rs4690213 chr4:1054868 C/T cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.7e-7 Recombination rate (females); CESC cis rs1949733 0.701 rs2631754 chr4:8449233 A/G cg11789530 chr4:8429930 ACOX3 0.76 10.94 0.56 3.06e-23 Response to antineoplastic agents; CESC cis rs2236918 1.000 rs1635509 chr1:242028027 C/T cg17736920 chr1:242011382 EXO1 0.68 9.18 0.49 1.28e-17 Menopause (age at onset); CESC cis rs13102973 0.965 rs4437307 chr4:135861598 C/T cg14419869 chr4:135874104 NA -0.39 -6.11 -0.35 3.51e-9 Subjective well-being; CESC cis rs78456975 0.527 rs7590742 chr2:1575049 A/T cg12573674 chr2:1569213 NA -0.46 -5.2 -0.3 3.96e-7 Placebo response in major depressive disorder (% change in symptom score); CESC cis rs933688 0.532 rs10072084 chr5:90539203 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.47 5.86 0.34 1.37e-8 Smoking behavior; CESC cis rs5750830 0.594 rs5757648 chr22:39775156 G/A cg24399712 chr22:39784796 NA -0.77 -11.05 -0.56 1.34e-23 Intelligence (multi-trait analysis); CESC cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg06634786 chr22:41940651 POLR3H 0.7 7.5 0.42 9.63e-13 Vitiligo; CESC cis rs56399783 0.901 rs73047393 chr7:2775879 C/T cg19731401 chr7:2775893 GNA12 0.7 6.33 0.36 1.02e-9 Childhood ear infection; CESC cis rs7647973 0.710 rs2029591 chr3:49646981 C/T cg03060546 chr3:49711283 APEH -0.62 -6.99 -0.39 2.26e-11 Menarche (age at onset); CESC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg08470875 chr2:26401718 FAM59B -0.75 -7.79 -0.43 1.49e-13 Gut microbiome composition (summer); CESC cis rs7259376 0.818 rs8101997 chr19:22568432 A/T cg02657401 chr19:22469223 NA -0.25 -5.1 -0.3 6.58e-7 Menopause (age at onset); CESC cis rs9911578 1.000 rs2611782 chr17:56717956 T/C cg12560992 chr17:57184187 TRIM37 0.93 15.58 0.69 2.6e-39 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08130813 chr19:46195655 QPCTL;SNRPD2 0.52 6.15 0.35 2.79e-9 Gut microbiome composition (summer); CESC cis rs9640161 0.830 rs3757424 chr7:150067679 C/A cg10018233 chr7:150070692 REPIN1 0.49 8.94 0.48 6.79e-17 Blood protein levels;Circulating chemerin levels; CESC cis rs1153858 0.621 rs1706824 chr15:45579948 C/T cg09092052 chr15:45571596 NA -0.46 -5.16 -0.3 4.76e-7 Homoarginine levels; CESC cis rs644799 1.000 rs644799 chr11:95564259 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 13.92 0.65 1.91e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6496667 1.000 rs8026533 chr15:90893228 A/C cg22089800 chr15:90895588 ZNF774 0.57 5.76 0.33 2.27e-8 Rheumatoid arthritis; CESC cis rs9858542 0.953 rs6809216 chr3:49412559 G/A cg07274523 chr3:49395745 GPX1 0.68 8.44 0.46 2.17e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs12142240 0.698 rs6695043 chr1:46844530 A/G cg10495392 chr1:46806563 NSUN4 -0.53 -5.86 -0.34 1.35e-8 Menopause (age at onset); CESC cis rs1568889 0.838 rs11030229 chr11:28173634 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 13.43 0.64 1.02e-31 Bipolar disorder; CESC cis rs72781680 0.566 rs72794293 chr2:23898149 A/G cg20701182 chr2:24300061 SF3B14 0.65 6.59 0.38 2.4e-10 Lymphocyte counts; CESC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg07167872 chr1:205819463 PM20D1 0.41 5.91 0.34 1.03e-8 Prostate-specific antigen levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24043307 chr12:51157954 ATF1 -0.63 -7.1 -0.4 1.12e-11 Gut microbiome composition (summer); CESC cis rs854765 0.583 rs28428991 chr17:17827649 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.28 0.41 3.9e-12 Total body bone mineral density; CESC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg09365446 chr1:150670422 GOLPH3L 0.39 5.1 0.3 6.59e-7 Melanoma; CESC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg12963246 chr6:28129442 ZNF389 0.49 6.31 0.36 1.18e-9 Parkinson's disease; CESC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg23758822 chr17:41437982 NA 1.02 15.55 0.69 3.45e-39 Menopause (age at onset); CESC cis rs6460942 1.000 rs77494477 chr7:12315302 A/T cg02935154 chr7:12443704 VWDE -0.59 -5.84 -0.34 1.5e-8 Coronary artery disease; CESC cis rs7560272 0.538 rs4852976 chr2:73936322 T/C cg20560298 chr2:73613845 ALMS1 0.45 6.18 0.35 2.43e-9 Schizophrenia; CESC cis rs41271473 0.500 rs10916366 chr1:228894575 T/C cg00850481 chr1:228891306 NA -0.51 -7.84 -0.43 1.11e-13 Chronic lymphocytic leukemia; CESC cis rs2832191 0.791 rs4817270 chr21:30480368 G/A cg24692254 chr21:30365293 RNF160 -0.8 -12.52 -0.61 1.4e-28 Dental caries; CESC cis rs7193541 0.694 rs8061942 chr16:74691362 C/T cg05580060 chr16:74700937 RFWD3 -0.47 -6.01 -0.35 6.11e-9 Multiple myeloma; CESC cis rs10823500 0.777 rs10509321 chr10:71985733 A/G cg02100629 chr10:71892760 AIFM2 0.33 5.24 0.31 3.36e-7 Blood protein levels; CESC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.59 7.21 0.41 5.72e-12 Height; CESC cis rs11078597 0.731 rs4989024 chr17:1639719 A/G cg18436246 chr17:1640651 WDR81 0.62 7.54 0.42 7.44e-13 Serum albumin level; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg23359706 chr19:11491839 EPOR -0.42 -6.05 -0.35 4.94e-9 Gambling; CESC cis rs6121246 0.542 rs6059761 chr20:30110522 G/C cg13852791 chr20:30311386 BCL2L1 0.65 6.87 0.39 4.61e-11 Mean corpuscular hemoglobin; CESC cis rs6580649 0.941 rs11613485 chr12:48462455 T/C cg05342945 chr12:48394962 COL2A1 0.51 5.91 0.34 1.07e-8 Lung cancer; CESC cis rs1808579 0.904 rs2960578 chr18:21143739 A/C cg14672496 chr18:21087552 C18orf8 0.39 5.72 0.33 2.83e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg23018236 chr17:30244563 NA -0.55 -5.31 -0.31 2.37e-7 Hip circumference adjusted for BMI; CESC cis rs9611565 0.765 rs132905 chr22:41799106 C/A cg03806693 chr22:41940476 POLR3H 1.04 12.34 0.6 6.13e-28 Vitiligo; CESC cis rs9287719 0.649 rs58633964 chr2:10736382 T/G cg02196655 chr2:10830764 NOL10 -0.38 -5.74 -0.33 2.53e-8 Prostate cancer; CESC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg26732615 chr19:19648335 CILP2;YJEFN3 -0.44 -5.58 -0.32 5.92e-8 Tonsillectomy; CESC cis rs2370759 0.945 rs74625866 chr10:32597618 A/T cg01819863 chr10:32635814 EPC1 1.16 13.32 0.63 2.38e-31 Sexual dysfunction (female); CESC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.24 0.31 3.29e-7 Tonsillectomy; CESC cis rs62344088 1.000 rs6880143 chr5:137516 C/T cg22857025 chr5:266934 NA -0.93 -5.86 -0.34 1.34e-8 Asthma (childhood onset); CESC cis rs761746 0.960 rs5998042 chr22:31953962 T/C cg25791279 chr22:32026902 PISD 0.52 6.15 0.35 2.78e-9 Intelligence; CESC cis rs9910055 0.529 rs228748 chr17:42174390 G/A cg08499158 chr17:42289980 UBTF 0.41 5.06 0.3 8.02e-7 Total body bone mineral density; CESC cis rs7301826 0.627 rs4325342 chr12:131312482 G/A cg11011512 chr12:131303247 STX2 0.46 5.75 0.33 2.48e-8 Plasma plasminogen activator levels; CESC cis rs1801251 1.000 rs9653383 chr2:233670380 A/C cg25237894 chr2:233734115 C2orf82 -0.46 -8.0 -0.44 4.02e-14 Coronary artery disease; CESC cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.39 -6.78 -0.38 8e-11 Hemoglobin concentration; CESC cis rs7508 0.711 rs3810 chr8:17914117 T/G cg18067069 chr8:17937731 ASAH1 -0.43 -5.54 -0.32 7.22e-8 Atrial fibrillation; CESC cis rs7833986 0.501 rs2976012 chr8:56974343 T/C cg26371346 chr8:56986568 SNORD54;RPS20 0.57 5.16 0.3 4.9e-7 Height; CESC cis rs6500395 1.000 rs6500398 chr16:48650332 C/T cg04672837 chr16:48644449 N4BP1 0.51 6.21 0.36 2.08e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19628164 chr3:143689916 C3orf58 0.58 6.54 0.37 3.15e-10 Gut microbiome composition (summer); CESC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg21963583 chr11:68658836 MRPL21 0.42 5.7 0.33 3.21e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs11264213 0.786 rs72659698 chr1:36314688 G/A cg27506609 chr1:36549197 TEKT2 0.65 5.49 0.32 9.31e-8 Schizophrenia; CESC cis rs9815354 0.812 rs809930 chr3:42065005 A/G cg03022575 chr3:42003672 ULK4 0.46 5.38 0.31 1.67e-7 Pulse pressure;Diastolic blood pressure; CESC cis rs9487051 0.734 rs56214745 chr6:109536748 G/T cg01475377 chr6:109611718 NA -0.44 -6.69 -0.38 1.32e-10 Reticulocyte fraction of red cells; CESC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg12463550 chr7:65579703 CRCP 0.56 7.24 0.41 4.94e-12 Aortic root size; CESC cis rs1797885 0.564 rs2596820 chr3:12601941 G/A cg26432171 chr3:12704882 RAF1 -0.49 -6.48 -0.37 4.45e-10 Immature fraction of reticulocytes; CESC cis rs4853012 0.941 rs7571083 chr2:74342260 C/G cg20891558 chr2:74357851 NA 0.69 9.14 0.49 1.7e-17 Gestational age at birth (maternal effect); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg16609855 chr10:91011618 LIPA -0.44 -6.33 -0.36 1.07e-9 Gambling; CESC cis rs7129220 0.545 rs61520995 chr11:10139467 C/T cg01453529 chr11:10209919 SBF2 -0.48 -5.63 -0.33 4.67e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs7520050 0.931 rs6688365 chr1:46329884 G/C cg03146154 chr1:46216737 IPP -0.48 -6.22 -0.36 1.98e-9 Red blood cell count;Reticulocyte count; CESC cis rs7647973 0.592 rs6774202 chr3:49687779 T/G cg07636037 chr3:49044803 WDR6 0.54 6.59 0.38 2.39e-10 Menarche (age at onset); CESC cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg04267008 chr7:1944627 MAD1L1 -0.75 -9.97 -0.52 4.38e-20 Bipolar disorder and schizophrenia; CESC cis rs4654899 1.000 rs6426669 chr1:21430584 C/A cg05370193 chr1:21551575 ECE1 0.38 5.63 0.33 4.52e-8 Superior frontal gyrus grey matter volume; CESC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg24531977 chr5:56204891 C5orf35 -0.55 -7.25 -0.41 4.69e-12 Coronary artery disease; CESC cis rs9325144 0.600 rs10880934 chr12:38730455 C/T cg26384229 chr12:38710491 ALG10B -0.56 -7.85 -0.43 1.03e-13 Morning vs. evening chronotype; CESC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Tonsillectomy; CESC cis rs1808579 0.870 rs11665096 chr18:21118025 G/C cg14672496 chr18:21087552 C18orf8 0.4 6.11 0.35 3.59e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs7512552 0.839 rs1498308 chr1:150295131 G/T cg15654264 chr1:150340011 RPRD2 0.38 5.11 0.3 6.14e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs910316 0.737 rs175424 chr14:75626257 T/C cg16144293 chr14:75469539 EIF2B2 0.39 5.04 0.3 8.77e-7 Height; CESC cis rs561341 1.000 rs550923 chr17:30327013 G/C cg19193384 chr17:30244184 NA -0.7 -6.58 -0.37 2.49e-10 Hip circumference adjusted for BMI; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg18367020 chr2:73461259 CCT7;C2orf7 0.65 7.09 0.4 1.19e-11 Gut microbiome composition (summer); CESC cis rs7945705 0.967 rs10769973 chr11:8928615 C/G cg09997546 chr11:8931473 C11orf17;ST5 0.38 6.0 0.35 6.57e-9 Hemoglobin concentration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23285320 chr19:36546349 THAP8;WDR62 0.48 6.13 0.35 3.2e-9 Gut microbiota (bacterial taxa); CESC cis rs78707713 0.841 rs77784890 chr10:71199295 G/C cg12610070 chr10:71211762 TSPAN15 -0.43 -7.33 -0.41 2.71e-12 Venous thromboembolism; CESC cis rs7647973 0.769 rs11130181 chr3:49109919 G/A cg06212747 chr3:49208901 KLHDC8B 0.52 6.23 0.36 1.81e-9 Menarche (age at onset); CESC cis rs2070488 0.965 rs7642472 chr3:38525567 T/C cg24069376 chr3:38537580 EXOG 0.49 9.06 0.49 3.04e-17 Electrocardiographic conduction measures; CESC cis rs3096299 0.967 rs753853 chr16:89446525 G/T cg16743903 chr16:89593216 SPG7 -0.46 -5.85 -0.34 1.43e-8 Multiple myeloma (IgH translocation); CESC cis rs9403521 1.000 rs9403521 chr6:143994199 C/T cg18240653 chr6:144019428 PHACTR2 0.49 5.57 0.32 6.12e-8 Obesity-related traits; CESC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.21 0.36 2.01e-9 Menopause (age at onset); CESC cis rs16858210 0.520 rs10460892 chr3:183546124 C/T cg03417191 chr3:183542750 MAP6D1 -0.72 -8.48 -0.46 1.64e-15 Menopause (age at onset); CESC cis rs704 0.585 rs2227735 chr17:26693258 C/T cg10342447 chr17:26645325 TMEM97 -0.43 -5.93 -0.34 9.49e-9 Osteoprotegerin levels; CESC cis rs1707322 0.721 rs6429575 chr1:46134216 G/C cg05343316 chr1:45956843 TESK2 0.5 6.12 0.35 3.43e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7267979 0.932 rs449703 chr20:25458559 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.78 14.78 0.67 1.87e-36 Liver enzyme levels (alkaline phosphatase); CESC cis rs910316 0.789 rs175457 chr14:75584507 C/T cg11812906 chr14:75593930 NEK9 -0.82 -13.29 -0.63 3.25e-31 Height; CESC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg03351412 chr1:154909251 PMVK 0.6 7.72 0.43 2.4e-13 Prostate cancer; CESC cis rs7605827 0.704 rs2160695 chr2:15673478 T/A cg19274914 chr2:15703543 NA 0.38 6.8 0.39 7.12e-11 Educational attainment (years of education); CESC cis rs933688 1.000 rs4382199 chr5:90744228 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 10.98 0.56 2.38e-23 Smoking behavior; CESC cis rs2637266 1.000 rs7914880 chr10:78363693 A/G cg18941641 chr10:78392320 NA 0.44 8.3 0.45 5.27e-15 Pulmonary function; CESC cis rs3091242 0.933 rs35530120 chr1:25785451 A/G cg02931644 chr1:25747376 RHCE -0.39 -6.43 -0.37 5.82e-10 Erythrocyte sedimentation rate; CESC cis rs561341 1.000 rs501957 chr17:30314504 C/T cg23018236 chr17:30244563 NA -0.52 -5.11 -0.3 6.22e-7 Hip circumference adjusted for BMI; CESC cis rs28830936 1.000 rs17677199 chr15:41954613 C/G cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.37 -5.32 -0.31 2.16e-7 Diastolic blood pressure; CESC cis rs7503807 0.664 rs9913181 chr17:78573872 A/C cg09596252 chr17:78655493 RPTOR 0.39 5.27 0.31 2.87e-7 Obesity; CESC trans rs4824093 0.610 rs77128035 chr22:50241024 C/T cg09872104 chr7:134855509 C7orf49 -0.95 -6.69 -0.38 1.32e-10 Amyotrophic lateral sclerosis (sporadic); CESC cis rs9309473 1.000 rs2901438 chr2:73665656 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.25 -0.36 1.62e-9 Metabolite levels; CESC cis rs2204008 0.728 rs11495375 chr12:38282631 G/A cg13010199 chr12:38710504 ALG10B 0.52 6.38 0.36 8.04e-10 Bladder cancer; CESC cis rs3733585 0.699 rs7663079 chr4:9966771 T/C cg11266682 chr4:10021025 SLC2A9 -0.58 -10.94 -0.56 3.08e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs11901793 0.505 rs11688053 chr2:237494289 A/T cg25295825 chr2:237489920 CXCR7 0.66 5.86 0.34 1.38e-8 Total mean fractional anisotropy measurement in first episode schizophrenia; CESC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg01416388 chr22:39784598 NA -0.56 -6.57 -0.37 2.58e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC trans rs1728785 0.901 rs7194664 chr16:68643313 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 7.71 0.43 2.5e-13 Ulcerative colitis; CESC cis rs9303280 0.901 rs883770 chr17:38063381 C/T cg19468946 chr17:37922297 IKZF3 -0.41 -5.53 -0.32 7.55e-8 Self-reported allergy; CESC cis rs7945705 0.935 rs10769971 chr11:8925276 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.38 6.0 0.35 6.57e-9 Hemoglobin concentration; CESC cis rs7953508 0.711 rs11107117 chr12:93979419 T/C cg18151635 chr12:93972918 NA -0.37 -5.08 -0.3 7.18e-7 Pubertal anthropometrics; CESC cis rs8114671 0.562 rs6058120 chr20:33402829 A/G cg24642439 chr20:33292090 TP53INP2 0.44 5.24 0.31 3.24e-7 Height; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg09169215 chr1:120839390 FAM72B -0.49 -6.4 -0.37 6.88e-10 Fibrinogen levels; CESC cis rs3892630 0.824 rs12976069 chr19:33280084 G/A cg22980127 chr19:33182716 NUDT19 1.03 11.61 0.58 1.79e-25 Red blood cell traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg24553691 chr21:47706090 MCM3AP;C21orf57 -0.4 -6.0 -0.35 6.31e-9 Gambling; CESC trans rs35110281 0.659 rs73367822 chr21:45024252 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 6.53 0.37 3.38e-10 Mean corpuscular volume; CESC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg13206674 chr6:150067644 NUP43 0.42 5.89 0.34 1.19e-8 Lung cancer; CESC cis rs8067545 0.611 rs757494 chr17:20150340 C/T cg13482628 chr17:19912719 NA -0.43 -5.63 -0.33 4.59e-8 Schizophrenia; CESC cis rs3749237 0.964 rs7431078 chr3:49808190 G/A cg03060546 chr3:49711283 APEH 0.64 7.46 0.42 1.21e-12 Resting heart rate; CESC cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg18512352 chr11:47633146 NA -0.6 -9.28 -0.5 6.06e-18 Subjective well-being; CESC trans rs7786808 0.712 rs2335167 chr7:158213948 A/C cg03441993 chr4:55093323 NA 0.4 6.22 0.36 1.97e-9 Obesity-related traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg08370882 chr2:219522648 ZNF142 0.41 6.01 0.35 6.08e-9 Gut microbiota (bacterial taxa); CESC cis rs921968 0.541 rs576901 chr2:219424364 A/G cg02176678 chr2:219576539 TTLL4 0.5 8.97 0.48 5.39e-17 Mean corpuscular hemoglobin concentration; CESC trans rs116095464 0.558 rs7703803 chr5:292311 A/G cg00938859 chr5:1591904 SDHAP3 0.65 7.04 0.4 1.67e-11 Breast cancer; CESC cis rs9611565 0.570 rs12159188 chr22:42121125 A/T cg03806693 chr22:41940476 POLR3H 0.89 10.32 0.54 3.36e-21 Vitiligo; CESC cis rs11792861 0.851 rs4542004 chr9:111814478 A/G cg05043794 chr9:111880884 C9orf5 -0.38 -6.46 -0.37 5.1e-10 Menarche (age at onset); CESC cis rs8133932 0.654 rs7277632 chr21:47327542 A/G cg14185626 chr21:47401492 COL6A1 0.45 5.19 0.3 4.28e-7 Schizophrenia; CESC cis rs9291683 0.609 rs13149985 chr4:10028390 G/A cg00071950 chr4:10020882 SLC2A9 0.88 16.02 0.7 7.4e-41 Bone mineral density; CESC cis rs739401 0.595 rs6578304 chr11:2998279 A/G cg25174290 chr11:3078921 CARS -0.52 -7.05 -0.4 1.56e-11 Longevity; CESC cis rs11785693 0.862 rs13281354 chr8:4987756 G/T cg26367366 chr8:4980734 NA 0.96 8.72 0.47 3.19e-16 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs7818688 0.697 rs3802192 chr8:95987471 C/T cg16049864 chr8:95962084 TP53INP1 0.55 5.6 0.33 5.32e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs2228479 0.850 rs62052711 chr16:89855100 C/A cg04013166 chr16:89971882 TCF25 0.78 6.67 0.38 1.44e-10 Skin colour saturation; CESC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg00149659 chr3:10157352 C3orf10 0.77 9.66 0.51 4.22e-19 Alzheimer's disease; CESC cis rs1707322 0.686 rs3014236 chr1:46091305 T/C cg06784218 chr1:46089804 CCDC17 -0.42 -7.37 -0.41 2.13e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7116495 1.000 rs2511079 chr11:71804154 C/T cg10381502 chr11:71823885 C11orf51 -0.62 -5.55 -0.32 6.83e-8 Severe influenza A (H1N1) infection; CESC cis rs12220238 1.000 rs11000930 chr10:75982982 C/G cg19889307 chr10:75911429 ADK;AP3M1 -0.64 -5.53 -0.32 7.72e-8 Soluble interleukin-2 receptor subunit alpha; CESC trans rs7902708 0.841 rs10824766 chr10:54428297 C/T cg26219051 chr22:43739629 SCUBE1 -0.48 -6.19 -0.36 2.25e-9 Bone properties (heel); CESC cis rs1018836 0.828 rs10956730 chr8:91597428 T/G cg16814680 chr8:91681699 NA -0.72 -10.81 -0.55 8.12e-23 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.11 19.45 0.77 6.01e-53 Height; CESC cis rs7267979 1.000 rs4815406 chr20:25341316 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -18.07 -0.74 3.95e-48 Liver enzyme levels (alkaline phosphatase); CESC cis rs9549367 0.737 rs71446680 chr13:113894846 C/T cg00898013 chr13:113819073 PROZ -0.54 -7.38 -0.41 2.03e-12 Platelet distribution width; CESC cis rs72627123 0.867 rs59892091 chr14:74417609 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.77 5.13 0.3 5.7e-7 Morning vs. evening chronotype; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04135372 chr2:99061383 INPP4A -0.43 -6.17 -0.35 2.56e-9 Fibrinogen levels; CESC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg18032046 chr6:28092343 ZSCAN16 -0.6 -6.84 -0.39 5.51e-11 Depression; CESC cis rs6750795 0.746 rs1667301 chr2:232423717 C/T cg09339159 chr2:232260559 B3GNT7 0.41 5.05 0.3 8.15e-7 Height; CESC cis rs7917772 0.503 rs6584510 chr10:104299868 T/G cg22532475 chr10:104410764 TRIM8 -0.35 -5.97 -0.34 7.47e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg23935330 chr11:66807597 SYT12 0.45 6.01 0.35 6.01e-9 Ulcerative colitis; CESC cis rs11190604 1.000 rs10883505 chr10:102280772 C/T cg07080220 chr10:102295463 HIF1AN 0.7 6.48 0.37 4.34e-10 Palmitoleic acid (16:1n-7) levels; CESC cis rs1355223 0.902 rs286862 chr11:34718779 A/G cg11058730 chr11:34937778 PDHX;APIP 0.49 6.73 0.38 1.05e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg12463550 chr7:65579703 CRCP 0.59 7.52 0.42 8.29e-13 Aortic root size; CESC cis rs6964587 0.869 rs11769294 chr7:91549937 C/T cg01689657 chr7:91764605 CYP51A1 0.31 5.65 0.33 4.06e-8 Breast cancer; CESC cis rs17253792 0.571 rs112129578 chr14:56028415 T/C cg01858014 chr14:56050164 KTN1 -0.97 -7.1 -0.4 1.17e-11 Putamen volume; CESC cis rs4332037 0.802 rs73048106 chr7:1929019 G/T cg23422044 chr7:1970798 MAD1L1 -0.57 -5.97 -0.34 7.76e-9 Bipolar disorder; CESC cis rs1577917 0.917 rs2197651 chr6:86495442 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.5 -6.65 -0.38 1.68e-10 Response to antipsychotic treatment; CESC cis rs5753037 0.653 rs131273 chr22:30153721 T/C cg01021169 chr22:30184971 ASCC2 -0.45 -6.16 -0.35 2.7e-9 Type 1 diabetes; CESC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg22800045 chr5:56110881 MAP3K1 -0.6 -7.95 -0.44 5.25e-14 Initial pursuit acceleration; CESC cis rs7100689 0.577 rs4934038 chr10:82057334 C/A cg00277334 chr10:82204260 NA -0.51 -6.55 -0.37 3.03e-10 Post bronchodilator FEV1; CESC trans rs61931739 0.517 rs11513519 chr12:34075077 G/A cg26384229 chr12:38710491 ALG10B 0.6 8.38 0.46 3.22e-15 Morning vs. evening chronotype; CESC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg17372223 chr3:52568218 NT5DC2 0.42 6.47 0.37 4.6e-10 Bipolar disorder; CESC cis rs1707322 0.721 rs10890333 chr1:46100322 T/C cg06784218 chr1:46089804 CCDC17 0.42 7.28 0.41 3.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7635838 0.596 rs347599 chr3:11258191 C/T cg00170343 chr3:11313890 ATG7 -0.5 -6.85 -0.39 5.09e-11 HDL cholesterol; CESC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg11764359 chr7:65958608 NA 0.79 11.52 0.58 3.66e-25 Aortic root size; CESC cis rs4820294 1.000 rs62236665 chr22:38059847 C/A cg21798802 chr22:38057573 PDXP 0.46 7.88 0.44 8.53e-14 Fat distribution (HIV); CESC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg06808227 chr14:105710500 BRF1 -0.58 -6.77 -0.38 8.26e-11 Mean platelet volume;Platelet distribution width; CESC cis rs7617773 1.000 rs9832957 chr3:48185266 A/G cg11946769 chr3:48343235 NME6 -0.67 -8.76 -0.47 2.43e-16 Coronary artery disease; CESC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg15117754 chr3:10150083 C3orf24 0.38 5.03 0.3 9.19e-7 Alzheimer's disease; CESC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg22590775 chr19:49891494 CCDC155 0.52 6.15 0.35 2.92e-9 Multiple sclerosis; CESC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg06873352 chr17:61820015 STRADA 0.72 12.67 0.61 4.43e-29 Prudent dietary pattern; CESC cis rs6502050 0.842 rs6502053 chr17:80066714 C/T cg23985595 chr17:80112537 CCDC57 0.41 6.34 0.36 9.73e-10 Life satisfaction; CESC cis rs7216064 1.000 rs6504548 chr17:65886048 T/C cg12091567 chr17:66097778 LOC651250 -0.83 -9.49 -0.5 1.38e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs6543140 0.964 rs11903551 chr2:103084181 C/G cg04239558 chr2:103089729 SLC9A4 0.47 6.23 0.36 1.83e-9 Blood protein levels; CESC cis rs1499614 0.831 rs3800822 chr7:66147149 A/G cg13147721 chr7:65941812 NA 0.96 9.03 0.49 3.53e-17 Gout; CESC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg18876405 chr7:65276391 NA 0.54 7.16 0.4 7.89e-12 Aortic root size; CESC cis rs9303401 0.614 rs3087762 chr17:56568680 C/T cg12560992 chr17:57184187 TRIM37 0.53 5.24 0.31 3.32e-7 Cognitive test performance; CESC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg11366901 chr6:160182831 ACAT2 0.63 8.02 0.44 3.33e-14 Age-related macular degeneration (geographic atrophy); CESC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.78 9.64 0.51 4.81e-19 Age-related macular degeneration (geographic atrophy); CESC cis rs9814567 1.000 rs7630874 chr3:134293291 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 6.1 0.35 3.71e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs796364 0.587 rs7588746 chr2:200986345 A/G cg23649088 chr2:200775458 C2orf69 0.55 6.36 0.36 8.85e-10 Schizophrenia; CESC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg10295955 chr4:187884368 NA -1.08 -22.04 -0.8 7.03e-62 Lobe attachment (rater-scored or self-reported); CESC cis rs60733400 0.817 rs4648657 chr1:2560735 A/G cg18854424 chr1:2615690 NA -0.29 -5.61 -0.33 4.98e-8 Multiple sclerosis; CESC trans rs62103177 0.714 rs28691615 chr18:77612254 C/T cg05926928 chr17:57297772 GDPD1 0.76 7.87 0.44 8.91e-14 Opioid sensitivity; CESC cis rs7631605 0.935 rs4678945 chr3:37239324 G/C cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.11 -0.3 6.31e-7 Cerebrospinal P-tau181p levels; CESC cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg19748678 chr4:122722346 EXOSC9 0.75 9.6 0.51 6.53e-19 Type 2 diabetes; CESC cis rs6088580 0.624 rs6120645 chr20:33025171 C/T cg24642439 chr20:33292090 TP53INP2 0.52 6.79 0.39 7.18e-11 Glomerular filtration rate (creatinine); CESC cis rs10644111 1 rs10644111 chr7:91652178 A/AAAC cg17063962 chr7:91808500 NA 0.56 7.69 0.43 2.84e-13 Breast cancer; CESC cis rs8064299 0.597 rs9893035 chr17:72783798 A/C cg25054828 chr17:72772726 NAT9;TMEM104 0.82 13.4 0.64 1.29e-31 Monocyte count; CESC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg03517284 chr6:25882590 NA -0.47 -6.26 -0.36 1.56e-9 Intelligence (multi-trait analysis); CESC cis rs7089973 0.604 rs7923693 chr10:116619566 A/G cg03647239 chr10:116582469 FAM160B1 0.47 6.05 0.35 4.79e-9 Bipolar disorder or attention deficit hyperactivity disorder; CESC cis rs7116495 1.000 rs7930721 chr11:71737481 C/A cg10381502 chr11:71823885 C11orf51 -0.64 -5.21 -0.3 3.81e-7 Severe influenza A (H1N1) infection; CESC cis rs910316 0.737 rs175048 chr14:75479894 A/T cg16144293 chr14:75469539 EIF2B2 0.4 5.32 0.31 2.24e-7 Height; CESC cis rs6582630 0.576 rs3900594 chr12:38272429 C/T cg26384229 chr12:38710491 ALG10B -0.46 -6.05 -0.35 4.85e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg21782813 chr7:2030301 MAD1L1 0.52 7.64 0.42 3.96e-13 Bipolar disorder and schizophrenia; CESC cis rs9863 0.861 rs34878139 chr12:124446253 T/C cg00084347 chr12:124393913 DNAH10 0.27 5.28 0.31 2.71e-7 White blood cell count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg24397552 chr15:40226086 EIF2AK4 -0.46 -6.37 -0.36 8.37e-10 Gut microbiota (bacterial taxa); CESC cis rs698833 0.819 rs1372078 chr2:44543389 A/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.46 -5.58 -0.32 6.04e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs739401 0.611 rs401707 chr11:3050965 T/C cg05729581 chr11:3078854 CARS -0.4 -5.28 -0.31 2.67e-7 Longevity; CESC cis rs11098499 0.954 rs17005535 chr4:120411562 C/T cg24375607 chr4:120327624 NA 0.46 5.72 0.33 2.83e-8 Corneal astigmatism; CESC cis rs7208859 0.524 rs60114476 chr17:29097667 A/T cg13385521 chr17:29058706 SUZ12P 0.81 6.54 0.37 3.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9399135 0.967 rs6929661 chr6:135328792 G/A cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg24733560 chr20:60626293 TAF4 0.44 6.18 0.36 2.38e-9 Body mass index; CESC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg19592336 chr6:28129416 ZNF389 0.54 6.94 0.39 3e-11 Parkinson's disease; CESC cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg24308560 chr3:49941425 MST1R 0.62 8.94 0.48 6.79e-17 Intelligence (multi-trait analysis); CESC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg18252515 chr7:66147081 NA 0.47 6.17 0.35 2.57e-9 Aortic root size; CESC trans rs61931739 0.890 rs1197560 chr12:34121447 G/C cg26384229 chr12:38710491 ALG10B 0.44 6.05 0.35 4.95e-9 Morning vs. evening chronotype; CESC trans rs2637266 0.505 rs11001808 chr10:78293852 A/G cg07899263 chr13:99293508 NA -0.39 -6.04 -0.35 5.08e-9 Pulmonary function; CESC cis rs863345 0.527 rs10797019 chr1:158490221 A/T cg12129480 chr1:158549410 OR10X1 -0.34 -6.85 -0.39 5.17e-11 Pneumococcal bacteremia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12639324 chr10:92617735 HTR7 0.58 7.47 0.42 1.14e-12 Gut microbiome composition (summer); CESC cis rs763014 0.898 rs916416 chr16:632198 T/A cg07343612 chr16:622815 PIGQ -0.57 -8.23 -0.45 8.47e-15 Height; CESC trans rs7849270 1.000 rs3118632 chr9:131901284 G/A cg05583848 chr6:35265411 DEF6 0.45 6.19 0.36 2.29e-9 Blood metabolite ratios; CESC cis rs9457247 1.000 rs422694 chr6:167406074 G/T cg23791538 chr6:167370224 RNASET2 -0.59 -8.54 -0.46 1.09e-15 Crohn's disease; CESC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg02725872 chr8:58115012 NA -0.41 -5.82 -0.34 1.69e-8 Developmental language disorder (linguistic errors); CESC cis rs7116495 0.609 rs10736783 chr11:71654143 G/A cg10381502 chr11:71823885 C11orf51 -1.1 -7.6 -0.42 5.21e-13 Severe influenza A (H1N1) infection; CESC cis rs854765 0.551 rs56886154 chr17:17831473 C/A cg04398451 chr17:18023971 MYO15A -0.65 -9.11 -0.49 2.08e-17 Total body bone mineral density; CESC cis rs7208487 0.684 rs12449852 chr17:37632088 A/G cg07936489 chr17:37558343 FBXL20 -0.91 -9.97 -0.52 4.37e-20 Primary biliary cholangitis;Glomerular filtration rate in non diabetics (creatinine); CESC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg27572855 chr1:25598939 RHD 0.42 7.0 0.4 2.06e-11 Erythrocyte sedimentation rate; CESC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.77 0.38 8.27e-11 Electroencephalogram traits; CESC cis rs2070997 0.816 rs1800609 chr9:133731184 A/G cg11464064 chr9:133710261 ABL1 0.63 6.23 0.36 1.81e-9 Response to amphetamines; CESC cis rs2346177 0.542 rs718849 chr2:46698116 G/A cg02822958 chr2:46747628 ATP6V1E2 0.44 5.5 0.32 9e-8 HDL cholesterol; CESC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg23985595 chr17:80112537 CCDC57 -0.42 -6.53 -0.37 3.31e-10 Life satisfaction; CESC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg11987759 chr7:65425863 GUSB -0.47 -6.22 -0.36 1.94e-9 Aortic root size; CESC cis rs3008870 1.000 rs35365746 chr1:67438900 G/A cg02640540 chr1:67518911 SLC35D1 -0.51 -5.54 -0.32 7.41e-8 Lymphocyte percentage of white cells; CESC cis rs1499972 0.878 rs817512 chr3:117734787 T/C cg07612923 chr3:117604196 NA -0.8 -5.97 -0.34 7.5e-9 Schizophrenia; CESC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg14262678 chr6:151773367 RMND1;C6orf211 -0.63 -8.97 -0.48 5.57e-17 Menarche (age at onset); CESC cis rs7918232 0.941 rs10829195 chr10:27431564 G/A cg14442939 chr10:27389572 ANKRD26 0.68 6.73 0.38 1.04e-10 Breast cancer; CESC cis rs7179456 0.517 rs7167872 chr15:59271375 T/C cg05156742 chr15:59063176 FAM63B 0.57 7.79 0.43 1.53e-13 Asperger disorder; CESC cis rs4975616 0.869 rs401681 chr5:1322087 C/T cg06550200 chr5:1325588 CLPTM1L -0.64 -9.81 -0.52 1.35e-19 Lung cancer; CESC cis rs2243480 1.000 rs60683927 chr7:65394768 T/C cg13147721 chr7:65941812 NA -0.83 -7.92 -0.44 6.77e-14 Diabetic kidney disease; CESC cis rs754466 1.000 rs56256440 chr10:79698207 A/G cg17075019 chr10:79541650 NA -0.73 -8.97 -0.48 5.61e-17 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs992157 0.764 rs10932774 chr2:219191569 A/G cg00012203 chr2:219082015 ARPC2 0.59 7.4 0.41 1.82e-12 Colorectal cancer; CESC cis rs9611565 0.559 rs739136 chr22:42100275 C/T cg03806693 chr22:41940476 POLR3H -1.15 -13.65 -0.64 1.77e-32 Vitiligo; CESC cis rs962856 0.619 rs6721534 chr2:67574662 G/A cg09028215 chr2:67624308 ETAA1 -0.44 -5.32 -0.31 2.2e-7 Pancreatic cancer; CESC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg23708337 chr7:1209742 NA 0.53 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs12971120 0.947 rs3764509 chr18:72167124 C/G cg25817165 chr18:72167213 CNDP2 -0.56 -7.72 -0.43 2.34e-13 Refractive error; CESC cis rs12541635 0.677 rs11781331 chr8:107066936 G/A cg10147462 chr8:107024639 NA -0.36 -5.06 -0.3 7.76e-7 Age of smoking initiation; CESC cis rs12477438 0.520 rs2969379 chr2:99776686 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.26 0.71 1.06e-41 Chronic sinus infection; CESC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.54 5.2 0.3 4.01e-7 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs10743315 0.732 rs17271857 chr12:19458136 C/T cg02471346 chr12:19282374 PLEKHA5 -0.66 -5.87 -0.34 1.32e-8 Gut microbiota (bacterial taxa); CESC cis rs2708240 1.000 rs2538986 chr7:147580726 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.36 -5.97 -0.34 7.69e-9 QT interval (drug interaction); CESC cis rs36229146 1 rs36229146 chr7:22784486 TTATATATAAATATATATATATATATA/T cg05265849 chr7:22767390 IL6 0.55 6.69 0.38 1.32e-10 Eosinophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CESC trans rs629535 0.814 rs545720 chr8:70063370 T/C cg21567404 chr3:27674614 NA 0.88 10.49 0.54 9.21e-22 Dupuytren's disease; CESC cis rs7786808 0.705 rs1377373 chr7:158215549 A/C cg01191920 chr7:158217561 PTPRN2 0.32 5.36 0.31 1.78e-7 Obesity-related traits; CESC cis rs34286592 1.000 rs3815824 chr16:29852860 C/T cg27338089 chr16:29820515 MAZ 0.48 5.04 0.3 8.68e-7 Multiple sclerosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03833794 chr17:78190983 SGSH -0.61 -6.49 -0.37 4.12e-10 Gut microbiome composition (summer); CESC cis rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11570347 chr4:99850390 EIF4E 0.59 6.64 0.38 1.81e-10 Gut microbiome composition (summer); CESC cis rs2439831 0.681 rs2278858 chr15:43632755 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.83 7.68 0.43 3.1400000000000003e-13 Lung cancer in ever smokers; CESC cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg20503657 chr10:835505 NA 0.66 7.2 0.4 6.1e-12 Eosinophil percentage of granulocytes; CESC cis rs2730245 1.000 rs2527199 chr7:158737113 G/A cg15303052 chr7:158526867 ESYT2 0.43 5.22 0.31 3.68e-7 Height; CESC cis rs1538970 0.924 rs1826691 chr1:45881262 A/G cg03146154 chr1:46216737 IPP -0.43 -5.13 -0.3 5.73e-7 Platelet count; CESC cis rs2235642 0.785 rs1057983 chr16:1660274 A/G cg03715980 chr16:1756201 MAPK8IP3 0.41 5.5 0.32 8.91e-8 Coronary artery disease; CESC cis rs17376456 0.825 rs13357713 chr5:93145423 T/C cg21475434 chr5:93447410 FAM172A 0.83 7.35 0.41 2.41e-12 Diabetic retinopathy; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07343429 chr11:1785120 HCCA2;CTSD -0.47 -6.43 -0.37 5.93e-10 Fibrinogen levels; CESC cis rs7537052 0.669 rs6686192 chr1:36642991 C/T cg24686825 chr1:36642396 MAP7D1 -0.57 -8.29 -0.45 5.68e-15 Schizophrenia; CESC trans rs1545843 0.593 rs61562209 chr12:84793389 A/G cg03015433 chr16:56623111 MT3 -0.34 -6.12 -0.35 3.37e-9 Major depressive disorder; CESC cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg05535760 chr7:792225 HEATR2 0.88 11.01 0.56 1.78e-23 Cerebrospinal P-tau181p levels; CESC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg17372223 chr3:52568218 NT5DC2 0.44 6.53 0.37 3.36e-10 Bipolar disorder; CESC cis rs1881797 1.000 rs10925069 chr1:247681313 C/T cg11166453 chr1:247681781 NA -0.49 -6.48 -0.37 4.55e-10 Acute lymphoblastic leukemia (childhood); CESC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs765787 0.530 rs11854294 chr15:45527996 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.23 -0.41 5.15e-12 Uric acid levels; CESC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg24642844 chr7:1081250 C7orf50 -0.41 -5.36 -0.31 1.82e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs17253792 0.822 rs10137885 chr14:56173590 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.65 5.35 0.31 1.9e-7 Putamen volume; CESC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg19346786 chr7:2764209 NA -0.46 -6.63 -0.38 1.93e-10 Height; CESC cis rs738322 0.967 rs2092180 chr22:38571563 A/G cg17652424 chr22:38574118 PLA2G6 -0.34 -6.04 -0.35 5.08e-9 Cutaneous nevi; CESC cis rs2573652 1.000 rs2581365 chr15:100513318 A/C cg09918751 chr15:100517450 ADAMTS17 -0.4 -7.81 -0.43 1.37e-13 Height; CESC cis rs5753037 0.543 rs131284 chr22:30157589 T/C cg01021169 chr22:30184971 ASCC2 -0.55 -7.84 -0.43 1.13e-13 Type 1 diabetes; CESC cis rs2070488 0.965 rs7433277 chr3:38529818 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.96 18.05 0.74 4.84e-48 Electrocardiographic conduction measures; CESC cis rs28830936 1.000 rs9672298 chr15:41912368 A/C cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.36 -5.14 -0.3 5.26e-7 Diastolic blood pressure; CESC cis rs9611565 0.592 rs5751129 chr22:42015765 C/T cg06481639 chr22:41940642 POLR3H 0.56 6.26 0.36 1.51e-9 Vitiligo; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg06937829 chr11:554920 C11orf35 -0.47 -6.08 -0.35 4.26e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6963495 1.000 rs6963495 chr7:105166853 T/C cg19920283 chr7:105172520 RINT1 0.64 5.35 0.31 1.89e-7 Bipolar disorder (body mass index interaction); CESC cis rs6973256 0.605 rs7792396 chr7:133345526 T/C cg10665199 chr7:133106180 EXOC4 0.46 6.17 0.35 2.51e-9 Intelligence (multi-trait analysis); CESC cis rs35955747 0.869 rs5753576 chr22:31757735 C/T cg02404636 chr22:31891804 SFI1 0.36 5.2 0.3 3.91e-7 Neutrophil count;Sum basophil neutrophil counts; CESC trans rs9944275 0.860 rs34405613 chr15:97188362 A/T cg26794346 chr6:16472305 ATXN1 0.75 6.06 0.35 4.65e-9 Depressive symptoms (multi-trait analysis);Neuroticism (multi-trait analysis); CESC cis rs2228479 0.850 rs62052711 chr16:89855100 C/A cg00800038 chr16:89945340 TCF25 -0.9 -7.5 -0.42 9.55e-13 Skin colour saturation; CESC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg16405210 chr4:1374714 KIAA1530 -0.93 -11.81 -0.59 3.74e-26 Longevity; CESC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg25036284 chr2:26402008 FAM59B 0.86 9.4 0.5 2.74e-18 Gut microbiome composition (summer); CESC cis rs9611565 0.572 rs139569 chr22:42211141 A/G cg06481639 chr22:41940642 POLR3H -0.45 -5.22 -0.31 3.53e-7 Vitiligo; CESC cis rs11690935 0.959 rs4667694 chr2:172605399 G/A cg13550731 chr2:172543902 DYNC1I2 -0.96 -14.06 -0.65 6.1e-34 Schizophrenia; CESC cis rs10089 1.000 rs10478796 chr5:127436187 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.77 10.67 0.55 2.39e-22 Ileal carcinoids; CESC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg06484146 chr7:12443880 VWDE -0.73 -8.75 -0.47 2.6e-16 Coronary artery disease; CESC cis rs9419702 0.526 rs9419637 chr10:133548059 T/C cg04492858 chr10:133558786 NA 0.45 6.62 0.38 2.02e-10 Survival in rectal cancer; CESC cis rs2929278 0.617 rs4617832 chr15:44030579 G/A cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -7.82 -0.43 1.27e-13 Schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04135372 chr2:99061383 INPP4A 0.61 7.3 0.41 3.45e-12 Gut microbiome composition (summer); CESC cis rs2243480 1.000 rs7456042 chr7:65299778 T/C cg13147721 chr7:65941812 NA -0.87 -8.61 -0.47 6.64e-16 Diabetic kidney disease; CESC cis rs11122272 0.735 rs910824 chr1:231498773 C/G cg06096015 chr1:231504339 EGLN1 0.43 6.26 0.36 1.57e-9 Hemoglobin concentration; CESC cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg14784868 chr12:69753453 YEATS4 -0.6 -8.37 -0.46 3.34e-15 Blood protein levels; CESC cis rs67478160 0.584 rs2295147 chr14:104195664 A/G cg08213375 chr14:104286397 PPP1R13B -0.37 -6.84 -0.39 5.33e-11 Schizophrenia; CESC trans rs17685 0.753 rs2286830 chr7:75693963 C/T cg19862616 chr7:65841803 NCRNA00174 -0.81 -11.9 -0.59 1.92e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs3892630 0.824 rs7247264 chr19:33239846 T/G cg22980127 chr19:33182716 NUDT19 1.03 11.34 0.57 1.42e-24 Red blood cell traits; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13894748 chr10:102107266 SCD -0.43 -6.16 -0.35 2.64e-9 Gambling; CESC trans rs10411161 0.702 rs8110531 chr19:52383510 C/T cg22319618 chr22:45562946 NUP50 -0.69 -6.75 -0.38 9.37e-11 Breast cancer; CESC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.72 6.41 0.37 6.71e-10 Platelet count; CESC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg12463550 chr7:65579703 CRCP 0.56 7.07 0.4 1.39e-11 Aortic root size; CESC cis rs1538970 0.924 rs10890327 chr1:45891458 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.46 0.32 1.11e-7 Platelet count; CESC cis rs7589342 0.839 rs12995333 chr2:106436366 A/C cg16077055 chr2:106428750 NCK2 -0.52 -7.38 -0.41 2.05e-12 Addiction; CESC cis rs1595825 1.000 rs79508374 chr2:198864568 G/A cg00982548 chr2:198649783 BOLL -0.44 -5.05 -0.3 8.32e-7 Ulcerative colitis; CESC cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg11752832 chr7:134001865 SLC35B4 0.55 7.12 0.4 9.94e-12 Mean platelet volume; CESC trans rs1908814 0.516 rs10113145 chr8:11793295 A/G cg15556689 chr8:8085844 FLJ10661 0.5 6.13 0.35 3.13e-9 Neuroticism; CESC cis rs6456156 0.586 rs911632 chr6:167471461 T/C cg07741184 chr6:167504864 NA 0.36 6.17 0.35 2.48e-9 Primary biliary cholangitis; CESC cis rs2832191 0.791 rs2832182 chr21:30481612 G/A cg08807101 chr21:30365312 RNF160 -0.76 -10.82 -0.55 7.78e-23 Dental caries; CESC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg24562669 chr7:97807699 LMTK2 0.48 7.1 0.4 1.13e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs7528419 1.000 rs646776 chr1:109818530 C/T cg00908766 chr1:109817496 CELSR2 0.47 6.65 0.38 1.64e-10 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CESC cis rs9359856 0.623 rs1179906 chr6:90323624 T/C cg13799429 chr6:90582589 CASP8AP2 -0.56 -6.44 -0.37 5.45e-10 Bipolar disorder; CESC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.27 -0.63 3.63e-31 Developmental language disorder (linguistic errors); CESC cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg05564831 chr3:52568323 NT5DC2 0.39 5.94 0.34 9e-9 Electroencephalogram traits; CESC trans rs3087243 0.729 rs231810 chr2:204712143 A/G cg01841312 chr10:38069945 NA 0.38 6.19 0.36 2.31e-9 Rheumatoid arthritis;Hypothyroidism;Type 1 diabetes; CESC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.29 0.31 2.51e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg23978390 chr7:1156363 C7orf50 0.57 5.85 0.34 1.45e-8 Bronchopulmonary dysplasia; CESC cis rs2073300 0.609 rs3827085 chr20:23356985 A/T cg12062639 chr20:23401060 NAPB 1.06 8.38 0.46 3.24e-15 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs5769765 1.000 rs5769765 chr22:50271176 G/A cg02269571 chr22:50332266 NA 0.46 6.28 0.36 1.39e-9 Schizophrenia; CESC cis rs7914558 0.933 rs1538204 chr10:104733893 T/A cg15744005 chr10:104629667 AS3MT -0.34 -5.31 -0.31 2.32e-7 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs17376456 0.877 rs10476597 chr5:93367172 C/T cg25358565 chr5:93447407 FAM172A -1.14 -10.65 -0.55 2.82e-22 Diabetic retinopathy; CESC cis rs8014204 0.804 rs35641442 chr14:75207263 G/A cg08847533 chr14:75593920 NEK9 0.48 5.98 0.34 7.26e-9 Caffeine consumption; CESC cis rs7084402 0.967 rs1649084 chr10:60292117 T/A cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs765787 0.530 rs12439643 chr15:45529767 A/G cg24006582 chr15:45444508 DUOX1 0.58 6.9 0.39 3.91e-11 Uric acid levels; CESC cis rs1003719 0.762 rs11088381 chr21:38478429 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs7560272 0.501 rs2006997 chr2:73947846 G/A cg20560298 chr2:73613845 ALMS1 0.43 5.83 0.34 1.57e-8 Schizophrenia; CESC cis rs1707322 0.964 rs785516 chr1:46564758 T/G cg03146154 chr1:46216737 IPP -0.74 -9.64 -0.51 4.75e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Tonsillectomy; CESC cis rs12765878 0.967 rs11598018 chr10:105661315 C/A cg11005552 chr10:105648138 OBFC1 0.35 5.06 0.3 7.79e-7 Coronary artery disease; CESC cis rs929354 0.742 rs1182396 chr7:157031831 A/C cg05182265 chr7:156933206 UBE3C 0.49 7.27 0.41 4.04e-12 Body mass index; CESC cis rs6460942 0.597 rs17448913 chr7:12533984 T/C cg20607287 chr7:12443886 VWDE -0.72 -7.71 -0.43 2.51e-13 Coronary artery disease; CESC cis rs4835937 0.590 rs6871743 chr5:127310093 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.57 5.36 0.31 1.79e-7 Cancer; CESC trans rs7618501 0.699 rs2681780 chr3:49897830 C/T cg21659725 chr3:3221576 CRBN 0.58 8.17 0.45 1.29e-14 Intelligence (multi-trait analysis); CESC cis rs2228479 0.541 rs13335395 chr16:89952843 T/A cg06558623 chr16:89946397 TCF25 0.58 5.66 0.33 3.93e-8 Skin colour saturation; CESC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg07167872 chr1:205819463 PM20D1 0.78 12.49 0.61 1.78e-28 Menarche (age at onset); CESC cis rs1018836 0.923 rs10808615 chr8:91569704 A/T cg16814680 chr8:91681699 NA -0.72 -10.29 -0.53 4.01e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs3008870 1.000 rs3008871 chr1:67419089 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -14.0 -0.65 1.03e-33 Lymphocyte percentage of white cells; CESC cis rs3008870 0.755 rs2815374 chr1:67507387 G/A cg02640540 chr1:67518911 SLC35D1 0.46 5.52 0.32 8.04e-8 Lymphocyte percentage of white cells; CESC cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg20503657 chr10:835505 NA 0.79 8.07 0.44 2.53e-14 Eosinophil percentage of granulocytes; CESC cis rs36051895 0.632 rs11791350 chr9:5172907 G/T cg02405213 chr9:5042618 JAK2 -0.48 -5.45 -0.32 1.14e-7 Pediatric autoimmune diseases; CESC cis rs2072499 0.750 rs55675376 chr1:156165881 C/T cg25208724 chr1:156163844 SLC25A44 0.98 12.72 0.62 2.94e-29 Testicular germ cell tumor; CESC cis rs7264396 0.513 rs2425092 chr20:34306815 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.75 0.38 9.35e-11 Total cholesterol levels; CESC cis rs72829446 0.530 rs2301609 chr17:7399866 G/A cg02795151 chr17:7402630 POLR2A 0.58 6.14 0.35 3.05e-9 Androgen levels; CESC cis rs826838 0.809 rs11169666 chr12:39211300 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.11 0.63 1.3e-30 Heart rate; CESC cis rs9858542 0.953 rs6766131 chr3:49538932 T/C cg03060546 chr3:49711283 APEH -0.55 -6.28 -0.36 1.34e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg02564969 chr6:151773285 C6orf211;RMND1 0.67 9.42 0.5 2.33e-18 Menarche (age at onset); CESC cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg17366294 chr4:99064904 C4orf37 0.59 8.46 0.46 1.8e-15 Colonoscopy-negative controls vs population controls; CESC cis rs5821446 1 rs5821446 chr17:65962538 A/AT cg07042672 chr17:66097459 LOC651250 0.64 8.07 0.44 2.44e-14 Eosinophil percentage of granulocytes; CESC cis rs854765 0.547 rs28537385 chr17:17902135 G/A cg16928487 chr17:17741425 SREBF1 -0.54 -9.23 -0.49 8.96e-18 Total body bone mineral density; CESC cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg23018236 chr17:30244563 NA -0.57 -5.56 -0.32 6.63e-8 Hip circumference adjusted for BMI; CESC trans rs637571 0.522 rs679581 chr11:65746653 A/G cg17712092 chr4:129076599 LARP1B 0.75 10.37 0.54 2.26e-21 Eosinophil percentage of white cells; CESC cis rs9815354 0.680 rs73073262 chr3:42018443 G/T cg03022575 chr3:42003672 ULK4 0.74 6.64 0.38 1.79e-10 Pulse pressure;Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27641051 chr5:137911203 HSPA9 0.66 7.93 0.44 6.07e-14 Gut microbiome composition (summer); CESC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs2249625 0.584 rs2463744 chr6:72875936 C/T cg18830697 chr6:72922368 RIMS1 -0.48 -7.18 -0.4 6.94e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CESC cis rs8060686 0.516 rs4640173 chr16:68163602 C/A cg26727032 chr16:67993705 SLC12A4 -0.52 -7.06 -0.4 1.42e-11 HDL cholesterol;Metabolic syndrome; CESC cis rs10883723 0.810 rs7094751 chr10:104274818 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.76e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs1062177 0.694 rs2915816 chr5:151115857 G/A cg12924095 chr5:151150029 G3BP1 -0.41 -5.5 -0.32 8.78e-8 Preschool internalizing problems; CESC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg19318889 chr4:1322082 MAEA 0.6 7.09 0.4 1.2e-11 Longevity; CESC cis rs7223966 1.000 rs8067064 chr17:61825984 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.66 0.38 1.6e-10 Hip circumference adjusted for BMI;Body mass index; CESC cis rs2901656 0.546 rs9425598 chr1:172371922 A/G cg03748243 chr1:172413542 C1orf105;PIGC 0.48 7.6 0.42 5.27e-13 Red cell distribution width;Platelet distribution width; CESC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg21724239 chr8:58056113 NA 0.6 5.44 0.32 1.21e-7 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09152490 chr1:160098579 ATP1A2 -0.61 -7.83 -0.43 1.19e-13 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg00482020 chr16:25026850 ARHGAP17 -0.45 -6.63 -0.38 1.84e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg06634786 chr22:41940651 POLR3H -0.72 -7.51 -0.42 9.19e-13 Vitiligo; CESC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg18099408 chr3:52552593 STAB1 -0.39 -7.02 -0.4 1.83e-11 Electroencephalogram traits; CESC cis rs9486719 1.000 rs11152968 chr6:96908653 A/G cg06623918 chr6:96969491 KIAA0776 0.78 7.87 0.44 9.05e-14 Migraine;Coronary artery disease; CESC cis rs11122272 0.735 rs2491408 chr1:231519248 C/G cg06096015 chr1:231504339 EGLN1 0.43 6.18 0.35 2.46e-9 Hemoglobin concentration; CESC cis rs28829049 0.597 rs2313509 chr1:19437860 C/T cg13387374 chr1:19411106 UBR4 0.42 5.32 0.31 2.26e-7 QRS duration in Tripanosoma cruzi seropositivity; CESC trans rs9929218 0.507 rs62057805 chr16:68742390 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.9 14.6 0.67 8.11e-36 Colorectal cancer; CESC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg02725872 chr8:58115012 NA -0.42 -6.61 -0.38 2.1e-10 Developmental language disorder (linguistic errors); CESC trans rs17772222 0.696 rs28666030 chr14:88977807 A/G cg16524936 chr4:1340807 KIAA1530 -0.5 -6.01 -0.35 5.96e-9 Coronary artery calcification; CESC cis rs4595586 0.505 rs6580897 chr12:39372254 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.13 0.4 9.33e-12 Morning vs. evening chronotype; CESC cis rs6456156 0.774 rs2022001 chr6:167529509 C/T cg07741184 chr6:167504864 NA -0.31 -5.12 -0.3 5.75e-7 Primary biliary cholangitis; CESC cis rs7520050 0.966 rs10789487 chr1:46420221 G/A cg03146154 chr1:46216737 IPP -0.47 -6.1 -0.35 3.74e-9 Red blood cell count;Reticulocyte count; CESC cis rs6840258 1.000 rs56050898 chr4:87945375 A/G cg08197287 chr4:87952173 AFF1 -0.4 -5.45 -0.32 1.17e-7 Mean corpuscular volume;Basophil percentage of granulocytes; CESC cis rs34172651 0.537 rs8049014 chr16:24698903 A/G cg04756594 chr16:24857601 SLC5A11 0.53 6.83 0.39 5.93e-11 Intelligence (multi-trait analysis); CESC cis rs12291225 0.535 rs11023203 chr11:14409815 G/A cg19336497 chr11:14380999 RRAS2 -0.37 -5.38 -0.31 1.67e-7 Sense of smell; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg26988692 chr8:37756473 RAB11FIP1 -0.48 -6.13 -0.35 3.16e-9 Ulcerative colitis; CESC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg13777783 chr17:79615861 NA -0.36 -6.12 -0.35 3.36e-9 Eye color traits; CESC cis rs9660180 0.967 rs61422524 chr1:1767565 C/A cg17747265 chr1:1875780 NA -0.56 -9.05 -0.49 3.07e-17 Body mass index; CESC cis rs854765 0.583 rs11078406 chr17:17840823 G/T cg09796270 chr17:17721594 SREBF1 0.4 5.57 0.32 6.21e-8 Total body bone mineral density; CESC cis rs6696846 0.515 rs11240364 chr1:205105917 C/G cg00857998 chr1:205179979 DSTYK 0.39 5.23 0.31 3.41e-7 Red blood cell count; CESC cis rs4481887 0.927 rs4916121 chr1:248432003 C/T cg00666640 chr1:248458726 OR2T12 0.41 6.81 0.39 6.53e-11 Common traits (Other); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27539746 chr10:118764201 KIAA1598 0.54 6.53 0.37 3.35e-10 Gut microbiome composition (summer); CESC cis rs3749237 1.000 rs4768 chr3:49758764 A/G cg03060546 chr3:49711283 APEH 0.64 7.51 0.42 9.34e-13 Resting heart rate; CESC cis rs7851660 0.809 rs7044799 chr9:100665393 A/T cg13688889 chr9:100608707 NA -0.63 -8.95 -0.48 6.33e-17 Strep throat; CESC cis rs3820928 0.874 rs1996998 chr2:227840294 C/A cg11843606 chr2:227700838 RHBDD1 -0.45 -5.8 -0.34 1.86e-8 Pulmonary function; CESC cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg11752832 chr7:134001865 SLC35B4 0.54 7.02 0.4 1.88e-11 Mean platelet volume; CESC cis rs3087591 0.960 rs8080679 chr17:29602610 A/G cg24425628 chr17:29625626 OMG;NF1 0.41 5.13 0.3 5.59e-7 Hip circumference; CESC cis rs7264396 0.635 rs6060720 chr20:34548336 A/C cg17201900 chr20:34330562 RBM39 0.5 5.22 0.31 3.71e-7 Total cholesterol levels; CESC cis rs7680126 0.633 rs4697975 chr4:10209966 A/T cg00071950 chr4:10020882 SLC2A9 -0.46 -5.23 -0.31 3.38e-7 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs6964587 0.839 rs62466809 chr7:91472801 A/G cg17063962 chr7:91808500 NA 0.5 6.46 0.37 4.98e-10 Breast cancer; CESC cis rs11677416 1.000 rs1800794 chr2:113543273 G/A cg27083787 chr2:113543245 IL1A 0.68 8.06 0.44 2.66e-14 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs72781680 0.948 rs113530757 chr2:24142500 G/A cg20701182 chr2:24300061 SF3B14 0.63 5.67 0.33 3.79e-8 Lymphocyte counts; CESC cis rs459571 0.635 rs379471 chr9:136890649 G/A cg13789015 chr9:136890014 NCRNA00094 0.55 7.9 0.44 7.61e-14 Platelet distribution width; CESC cis rs7095944 0.614 rs10901816 chr10:126440395 G/A cg08799069 chr10:126477246 METTL10 -0.37 -5.28 -0.31 2.66e-7 Asthma; CESC cis rs10751667 0.666 rs10902243 chr11:949900 T/C cg20946044 chr11:1010712 AP2A2 -0.38 -5.24 -0.31 3.23e-7 Alzheimer's disease (late onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg12037538 chr1:25664880 TMEM50A -0.48 -6.36 -0.36 8.66e-10 Gut microbiota (bacterial taxa); CESC trans rs9354352 0.935 rs9345749 chr6:66699892 G/T cg15322624 chr12:2922039 ITFG2 0.47 6.01 0.35 6.05e-9 Initial pursuit acceleration in psychotic disorders; CESC cis rs11229555 0.645 rs11530830 chr11:58252992 C/G cg15696309 chr11:58395628 NA 0.46 5.17 0.3 4.6e-7 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CESC cis rs6543140 0.964 rs6734203 chr2:103080066 G/C cg04239558 chr2:103089729 SLC9A4 0.47 6.16 0.35 2.64e-9 Blood protein levels; CESC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg15352829 chr14:105391018 PLD4 -0.6 -10.51 -0.54 8.09e-22 Rheumatoid arthritis; CESC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg06873352 chr17:61820015 STRADA 0.47 6.89 0.39 4.14e-11 Height; CESC cis rs11997175 0.624 rs7016783 chr8:33696831 A/G ch.8.33884649F chr8:33765107 NA 0.57 7.52 0.42 8.28e-13 Body mass index; CESC cis rs1062177 0.826 rs2915822 chr5:151130901 G/T cg12924095 chr5:151150029 G3BP1 -0.44 -5.71 -0.33 3.05e-8 Preschool internalizing problems; CESC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg22823121 chr1:150693482 HORMAD1 0.44 6.59 0.38 2.31e-10 Tonsillectomy; CESC cis rs9300255 0.568 rs1790102 chr12:123704890 G/A cg19016782 chr12:123741754 C12orf65 -0.45 -6.55 -0.37 2.97e-10 Neutrophil percentage of white cells; CESC cis rs13242816 1.000 rs34652384 chr7:116157011 T/C cg04696780 chr7:116139425 CAV2 -0.61 -5.55 -0.32 7.01e-8 P wave duration; CESC cis rs3093024 1.000 rs3093024 chr6:167532793 C/T cg07741184 chr6:167504864 NA 0.32 5.51 0.32 8.65e-8 Rheumatoid arthritis; CESC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg17971929 chr21:40555470 PSMG1 -0.92 -12.85 -0.62 1.08e-29 Cognitive function; CESC cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.84 -14.69 -0.67 3.82e-36 Birth weight; CESC trans rs931812 0.757 rs35569317 chr8:101907971 T/C cg20993868 chr7:22813445 NA 0.41 6.27 0.36 1.44e-9 Attention deficit hyperactivity disorder and conduct disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg01151424 chr11:17411006 KCNJ11 -0.46 -6.41 -0.37 6.82e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7851660 0.844 rs10123699 chr9:100637859 A/G cg13688889 chr9:100608707 NA -0.62 -8.66 -0.47 4.67e-16 Strep throat; CESC cis rs1018836 0.828 rs756568 chr8:91557038 G/C cg16814680 chr8:91681699 NA -0.64 -9.32 -0.5 4.86e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs17253792 0.822 rs75999534 chr14:56036413 A/T cg01858014 chr14:56050164 KTN1 -0.94 -6.83 -0.39 5.75e-11 Putamen volume; CESC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs9818758 0.607 rs35060561 chr3:49255503 T/C cg00383909 chr3:49044727 WDR6 0.79 6.01 0.35 5.98e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg03637622 chr5:179334771 TBC1D9B 0.46 6.19 0.36 2.28e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1109430 0.661 rs77959785 chr1:209891813 G/A cg02304930 chr1:210405566 SERTAD4;C1orf133 0.85 5.21 0.3 3.82e-7 Orofacial clefts; CESC cis rs11792861 0.926 rs7855282 chr9:111802614 T/A cg13535736 chr9:111863775 C9orf5 -0.49 -6.51 -0.37 3.85e-10 Menarche (age at onset); CESC cis rs4268898 0.965 rs13033241 chr2:24476118 G/C cg20701182 chr2:24300061 SF3B14 -0.41 -5.03 -0.3 9.04e-7 Asthma; CESC cis rs1670533 0.932 rs4690347 chr4:1057328 A/G cg04106633 chr4:1044584 NA 0.41 5.19 0.3 4.11e-7 Recombination rate (females); CESC cis rs6582630 0.555 rs10785454 chr12:38476260 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.82 0.55 7.82e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs561341 0.739 rs6505267 chr17:30225950 A/C cg13647721 chr17:30228624 UTP6 0.8 9.74 0.51 2.41e-19 Hip circumference adjusted for BMI; CESC cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg04546413 chr19:29218101 NA 0.49 6.22 0.36 1.91e-9 Methadone dose in opioid dependence; CESC cis rs9309473 0.950 rs6546854 chr2:73834034 A/G cg20560298 chr2:73613845 ALMS1 -0.53 -6.97 -0.39 2.47e-11 Metabolite levels; CESC cis rs7586879 0.639 rs6713978 chr2:25120851 T/C cg01884057 chr2:25150051 NA 0.36 7.01 0.4 2.02e-11 Body mass index; CESC cis rs8067354 0.645 rs2173119 chr17:57859705 C/T cg13753209 chr17:57696993 CLTC 0.57 6.44 0.37 5.46e-10 Hemoglobin concentration; CESC cis rs9911578 0.933 rs74370218 chr17:57095212 C/T cg05425664 chr17:57184151 TRIM37 0.52 7.19 0.4 6.69e-12 Intelligence (multi-trait analysis); CESC cis rs7208859 0.573 rs73277974 chr17:29189869 A/G cg19761014 chr17:28927070 LRRC37B2 0.72 5.71 0.33 3.06e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs61931739 0.500 rs11052994 chr12:34065843 C/T cg26384229 chr12:38710491 ALG10B 0.6 8.38 0.46 3.12e-15 Morning vs. evening chronotype; CESC cis rs727505 1.000 rs10241173 chr7:124453258 A/G cg23710748 chr7:124431027 NA -0.39 -6.4 -0.37 7.02e-10 Lewy body disease; CESC cis rs3733585 0.605 rs4235355 chr4:10123078 C/A cg02734326 chr4:10020555 SLC2A9 -0.37 -5.07 -0.3 7.36e-7 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7980687 0.628 rs2851443 chr12:123694250 C/T cg19016782 chr12:123741754 C12orf65 -0.34 -5.1 -0.3 6.4e-7 Height;Educational attainment;Head circumference (infant); CESC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -7.04 -0.4 1.69e-11 Extrinsic epigenetic age acceleration; CESC cis rs1023500 0.551 rs61665536 chr22:42512613 A/G cg04733989 chr22:42467013 NAGA -0.78 -11.9 -0.59 1.87e-26 Schizophrenia; CESC cis rs72772090 0.634 rs10515246 chr5:96099265 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.8 -0.34 1.85e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs9443189 0.526 rs10943255 chr6:76225928 T/A cg01950844 chr6:76311363 SENP6 0.89 9.14 0.49 1.73e-17 Prostate cancer; CESC cis rs7586673 0.930 rs2884364 chr2:161977647 G/A cg08807892 chr2:162101083 NA 0.46 6.27 0.36 1.48e-9 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03758523 chr6:151773469 C6orf211;RMND1 0.58 6.7 0.38 1.24e-10 Gut microbiome composition (summer); CESC cis rs258892 0.947 rs266435 chr5:72174432 C/G cg21869765 chr5:72125136 TNPO1 0.45 5.62 0.33 4.9e-8 Small cell lung carcinoma; CESC cis rs2243480 1.000 rs1723270 chr7:65469830 T/G cg25894440 chr7:65020034 NA -0.66 -5.69 -0.33 3.42e-8 Diabetic kidney disease; CESC cis rs1707322 1.000 rs10890350 chr1:46262378 G/A cg05343316 chr1:45956843 TESK2 0.45 5.6 0.33 5.36e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16238933 chr4:668052 ATP5I 0.65 6.84 0.39 5.6e-11 Gut microbiome composition (summer); CESC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg07747251 chr5:1868357 NA 0.33 5.47 0.32 1.05e-7 Cardiovascular disease risk factors; CESC cis rs10751667 0.666 rs7395321 chr11:940280 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.44 -0.32 1.23e-7 Alzheimer's disease (late onset); CESC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg05872129 chr22:39784769 NA 0.72 9.25 0.49 7.7e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg11279151 chr3:101281821 RG9MTD1 -0.46 -5.99 -0.35 6.92e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg15506890 chr2:3487001 NA -0.48 -6.03 -0.35 5.51e-9 Neurofibrillary tangles; CESC cis rs28374715 0.681 rs28728213 chr15:41653602 T/A cg02330683 chr15:41787940 ITPKA 0.47 6.17 0.35 2.56e-9 Ulcerative colitis; CESC cis rs6665290 0.870 rs1045289 chr1:227178713 C/T cg10327440 chr1:227177885 CDC42BPA -1.23 -34.55 -0.9 3.8e-100 Myeloid white cell count; CESC cis rs4535700 0.501 rs10245725 chr7:55976548 C/T cg09872392 chr7:56161020 PHKG1 -0.37 -5.47 -0.32 1.02e-7 Macular telangiectasia type 2; CESC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg22105103 chr4:187893119 NA -0.47 -6.79 -0.38 7.32e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs1538970 0.816 rs11211124 chr1:45962409 T/C cg24296786 chr1:45957014 TESK2 -0.46 -5.15 -0.3 4.97e-7 Platelet count; CESC cis rs6546550 0.901 rs7598283 chr2:70128717 A/G cg02498382 chr2:70120550 SNRNP27 -0.38 -6.6 -0.38 2.17e-10 Prevalent atrial fibrillation; CESC cis rs7020830 0.898 rs308521 chr9:37367094 T/C cg14294708 chr9:37120828 ZCCHC7 1.01 16.33 0.71 5.67e-42 Schizophrenia; CESC trans rs7615952 0.576 rs4646763 chr3:125822129 G/A cg07211511 chr3:129823064 LOC729375 -0.57 -6.28 -0.36 1.38e-9 Blood pressure (smoking interaction); CESC trans rs2643217 0.953 rs2643207 chr15:38999745 G/T cg02017892 chr8:103550807 NA -0.41 -6.01 -0.35 5.96e-9 Bipolar disorder and schizophrenia; CESC cis rs61990749 0.597 rs4903643 chr14:78254791 C/T cg21497246 chr14:78225524 SNW1;C14orf178 -0.47 -5.09 -0.3 6.77e-7 Fibroblast growth factor basic levels; CESC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg18337363 chr3:52569053 NT5DC2 0.28 5.15 0.3 5.08e-7 Bipolar disorder; CESC cis rs1355223 0.902 rs1773910 chr11:34741253 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.44 -0.37 5.45e-10 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs10256972 0.528 rs7784607 chr7:1178694 A/G cg07092213 chr7:1199455 ZFAND2A -0.42 -5.56 -0.32 6.66e-8 Longevity;Endometriosis; CESC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.52 5.81 0.34 1.75e-8 Lung function (FEV1/FVC); CESC cis rs826838 1.000 rs860400 chr12:39081279 A/G cg26384229 chr12:38710491 ALG10B -0.62 -9.75 -0.51 2.14e-19 Heart rate; CESC cis rs2228479 0.850 rs62056102 chr16:89941438 T/C cg04013166 chr16:89971882 TCF25 0.75 6.39 0.37 7.38e-10 Skin colour saturation; CESC cis rs11030122 0.702 rs11030276 chr11:3946134 A/G cg18678763 chr11:4115507 RRM1 -0.45 -6.05 -0.35 4.94e-9 Mean platelet volume;Platelet distribution width; CESC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg05863683 chr7:1912471 MAD1L1 0.35 5.12 0.3 5.76e-7 Autism spectrum disorder or schizophrenia; CESC cis rs939658 0.776 rs11631411 chr15:79445816 C/T cg17916960 chr15:79447300 NA -0.36 -5.94 -0.34 8.77e-9 Refractive error; CESC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.77 10.14 0.53 1.23e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg24881330 chr22:46731750 TRMU 0.81 7.25 0.41 4.61e-12 LDL cholesterol;Cholesterol, total; CESC cis rs752010 0.811 rs10749836 chr1:42086860 G/C cg06885757 chr1:42089581 HIVEP3 0.46 7.58 0.42 5.74e-13 Lupus nephritis in systemic lupus erythematosus; CESC cis rs57083693 0.518 rs10860710 chr12:101723467 A/G cg22051763 chr12:101673672 UTP20 -0.45 -5.59 -0.32 5.71e-8 Alcohol dependence (age at onset); CESC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg08968635 chr6:28129556 ZNF389 0.42 5.77 0.33 2.15e-8 Depression; CESC cis rs12464559 0.522 rs13016166 chr2:152624144 G/A cg01189475 chr2:152685088 ARL5A 0.72 7.26 0.41 4.26e-12 Response to cognitive-behavioural therapy in anxiety disorder; CESC cis rs61996546 0.622 rs12900771 chr15:26835235 G/A cg14859324 chr15:26874363 GABRB3 -0.38 -5.12 -0.3 6e-7 Response to methotrexate in juvenile idiopathic arthritis; CESC cis rs854765 0.663 rs3744115 chr17:17749822 G/A cg16928487 chr17:17741425 SREBF1 0.59 10.3 0.53 3.77e-21 Total body bone mineral density; CESC cis rs35110281 0.720 rs230647 chr21:44919654 C/T cg21573476 chr21:45109991 RRP1B 0.45 5.87 0.34 1.27e-8 Mean corpuscular volume; CESC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg04673462 chr1:38461896 NA 0.43 6.63 0.38 1.84e-10 Coronary artery disease; CESC cis rs3857067 0.967 rs1355240 chr4:95019353 C/T cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.04 -0.44 3.05e-14 QT interval; CESC cis rs7917772 0.582 rs10786695 chr10:104368756 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.4 5.51 0.32 8.5e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs6460942 0.908 rs6956500 chr7:12232120 T/C cg20607287 chr7:12443886 VWDE -0.47 -5.06 -0.3 7.96e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04393675 chr16:28986095 SPNS1 0.55 6.32 0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs77216612 1.000 rs77216612 chr12:12877983 A/G cg24098013 chr12:12878779 APOLD1 0.57 6.87 0.39 4.45e-11 Lymphocyte counts; CESC cis rs6460942 1.000 rs2053378 chr7:12405564 C/G cg06484146 chr7:12443880 VWDE -0.79 -8.75 -0.47 2.47e-16 Coronary artery disease; CESC cis rs2952156 0.684 rs1877031 chr17:37814080 G/A cg07936489 chr17:37558343 FBXL20 -0.6 -7.82 -0.43 1.27e-13 Asthma; CESC cis rs7542091 0.704 rs4133950 chr1:210044393 C/G cg21951975 chr1:209979733 IRF6 0.46 8.11 0.45 1.88e-14 Monobrow; CESC cis rs10927875 0.541 rs1763601 chr1:16340460 G/T cg22431228 chr1:16359049 CLCNKA -0.52 -9.96 -0.52 4.74e-20 Dilated cardiomyopathy; CESC cis rs9790314 0.967 rs6762645 chr3:160948349 T/G cg03342759 chr3:160939853 NMD3 -0.49 -6.41 -0.37 6.65e-10 Morning vs. evening chronotype; CESC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg26314531 chr2:26401878 FAM59B 0.84 9.2 0.49 1.13e-17 Gut microbiome composition (summer); CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg13789711 chr9:139743225 PHPT1 -0.54 -6.19 -0.36 2.33e-9 Lung cancer in ever smokers; CESC cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg26677194 chr12:130822605 PIWIL1 0.52 6.86 0.39 4.77e-11 Menopause (age at onset); CESC cis rs4835473 0.897 rs6537171 chr4:144630375 G/A cg25736465 chr4:144833511 NA 0.4 6.17 0.35 2.59e-9 Immature fraction of reticulocytes; CESC cis rs6754311 0.731 rs12615624 chr2:136721603 A/G cg07169764 chr2:136633963 MCM6 0.71 9.02 0.48 3.89e-17 Mosquito bite size; CESC cis rs10752881 1.000 rs10797813 chr1:182989366 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 13.31 0.63 2.66e-31 Colorectal cancer; CESC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs72634258 0.554 rs12092614 chr1:7865710 C/T cg26816564 chr1:7831052 VAMP3 0.64 5.96 0.34 7.92e-9 Inflammatory bowel disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06812651 chr1:234746099 IRF2BP2 0.59 6.33 0.36 1.04e-9 Gut microbiome composition (summer); CESC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.15 0.3 4.99e-7 Menopause (age at onset); CESC cis rs1538970 0.847 rs1771550 chr1:45883565 C/T cg05343316 chr1:45956843 TESK2 -0.8 -11.39 -0.57 9.77e-25 Platelet count; CESC cis rs2120019 0.938 rs35911108 chr15:75322179 G/A cg17294928 chr15:75287854 SCAMP5 -0.76 -8.79 -0.48 1.96e-16 Blood trace element (Zn levels); CESC cis rs9467711 0.606 rs12176317 chr6:26372786 A/G cg12826209 chr6:26865740 GUSBL1 0.62 5.24 0.31 3.25e-7 Autism spectrum disorder or schizophrenia; CESC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg06456125 chr7:65229604 NA -0.41 -5.4 -0.32 1.45e-7 Calcium levels; CESC cis rs2573652 1.000 rs2581345 chr15:100514291 A/G cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.53 -0.32 7.65e-8 Height; CESC trans rs2075371 0.932 rs1862048 chr7:133978167 C/G cg08692210 chr3:52188851 WDR51A 0.54 6.5 0.37 3.9e-10 Mean platelet volume; CESC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg12463550 chr7:65579703 CRCP -0.5 -6.34 -0.36 9.71e-10 Aortic root size; CESC cis rs7584330 0.740 rs11896232 chr2:238438124 T/C cg06639874 chr2:238417703 MLPH -0.37 -5.32 -0.31 2.2e-7 Prostate cancer; CESC cis rs4911259 0.552 rs13041458 chr20:31467376 G/T cg13636640 chr20:31349939 DNMT3B -0.54 -7.44 -0.42 1.45e-12 Inflammatory bowel disease; CESC cis rs2295499 0.754 rs4690052 chr4:2736567 C/T cg08330972 chr4:2403930 ZFYVE28 -0.33 -5.21 -0.3 3.89e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg18032046 chr6:28092343 ZSCAN16 -0.56 -5.43 -0.32 1.29e-7 Depression; CESC trans rs2439831 0.850 rs12702 chr15:44093927 C/T cg21735491 chr11:66749665 NA -0.54 -6.2 -0.36 2.2e-9 Lung cancer in ever smokers; CESC cis rs2404602 0.684 rs4886816 chr15:76874707 A/C cg23625390 chr15:77176239 SCAPER -0.43 -5.81 -0.34 1.76e-8 Blood metabolite levels; CESC cis rs644799 1.000 rs474442 chr11:95583995 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.56 6.93 0.39 3.11e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg21724239 chr8:58056113 NA 0.58 5.95 0.34 8.29e-9 Developmental language disorder (linguistic errors); CESC cis rs2404602 0.716 rs67204011 chr15:76846555 C/T cg22467129 chr15:76604101 ETFA -0.36 -5.35 -0.31 1.92e-7 Blood metabolite levels; CESC cis rs9359856 0.673 rs2039053 chr6:90303760 G/A cg13799429 chr6:90582589 CASP8AP2 0.48 5.31 0.31 2.33e-7 Bipolar disorder; CESC cis rs9581857 0.547 rs76971629 chr13:28051031 C/T cg01674679 chr13:27998804 GTF3A -0.67 -5.33 -0.31 2.07e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg12311346 chr5:56204834 C5orf35 0.75 9.33 0.5 4.51e-18 Initial pursuit acceleration; CESC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg17949981 chr6:28129498 ZNF389 0.45 5.48 0.32 9.77e-8 Depression; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg15039414 chr2:43454687 ZFP36L2;LOC100129726 0.45 6.02 0.35 5.88e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs561341 0.769 rs7217004 chr17:30178092 A/G cg00745463 chr17:30367425 LRRC37B 0.66 5.96 0.34 7.84e-9 Hip circumference adjusted for BMI; CESC cis rs9457247 1.000 rs398278 chr6:167388169 A/G cg07741184 chr6:167504864 NA 0.32 5.59 0.32 5.74e-8 Crohn's disease; CESC cis rs2797160 1.000 rs2747719 chr6:126009214 C/T cg05901451 chr6:126070800 HEY2 0.45 6.59 0.38 2.39e-10 Endometrial cancer; CESC cis rs7786808 0.741 rs11765319 chr7:158226790 A/G cg09998033 chr7:158218633 PTPRN2 -0.36 -5.45 -0.32 1.15e-7 Obesity-related traits; CESC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg24642844 chr7:1081250 C7orf50 -0.75 -9.03 -0.49 3.61e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1559088 1.000 rs8106453 chr19:33557412 C/T cg17764715 chr19:33622953 WDR88 0.45 5.63 0.33 4.66e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs1814175 0.645 rs11040535 chr11:49808669 C/T cg15704280 chr7:45808275 SEPT13 -0.96 -16.96 -0.72 3.4e-44 Height; CESC cis rs7786877 0.680 rs28584500 chr7:100216341 G/A cg20848291 chr7:100343083 ZAN -0.64 -6.73 -0.38 1.02e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.33 0.41 2.7e-12 Tonsillectomy; CESC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg11890956 chr21:40555474 PSMG1 -0.65 -8.96 -0.48 5.97e-17 Menarche (age at onset); CESC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.34 0.31 2.03e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2302190 0.882 rs11650710 chr17:56583547 C/T cg25885038 chr17:56607967 SEPT4 -0.4 -5.47 -0.32 1.02e-7 Vitamin D levels; CESC cis rs4466137 0.868 rs6866067 chr5:83022369 A/G cg16102102 chr5:83017553 HAPLN1 -0.51 -7.22 -0.41 5.5e-12 Prostate cancer; CESC cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg03433033 chr1:76189801 ACADM 0.65 7.67 0.43 3.3e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4692589 0.606 rs13127322 chr4:170935169 C/T cg19918862 chr4:170955249 NA 0.43 5.69 0.33 3.37e-8 Anxiety disorder; CESC cis rs10504073 0.584 rs11786103 chr8:49904077 A/G cg00325661 chr8:49890786 NA 0.53 8.09 0.45 2.12e-14 Blood metabolite ratios; CESC cis rs478304 0.651 rs4930313 chr11:65500428 C/T cg10518572 chr11:65560635 OVOL1 -0.33 -6.61 -0.38 2.09e-10 Acne (severe); CESC cis rs11122272 0.735 rs2474634 chr1:231487017 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -7.0 -0.39 2.15e-11 Hemoglobin concentration; CESC cis rs9815354 0.767 rs17281182 chr3:41817263 C/T cg03022575 chr3:42003672 ULK4 0.7 6.19 0.36 2.3e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs9916302 0.904 rs4357971 chr17:37717280 C/T cg07936489 chr17:37558343 FBXL20 -0.81 -11.66 -0.58 1.24e-25 Glomerular filtration rate (creatinine); CESC cis rs7777484 0.534 rs2533890 chr7:2828743 C/T cg19717773 chr7:2847554 GNA12 -0.69 -11.69 -0.58 1.01e-25 Height; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21047528 chr22:42915898 RRP7A -0.53 -6.68 -0.38 1.42e-10 Asthma; CESC cis rs12136530 0.774 rs10799810 chr1:19764032 G/A cg01832549 chr1:19774989 CAPZB -0.46 -6.42 -0.37 6.2e-10 Lead levels in blood; CESC cis rs4253772 0.638 rs6007845 chr22:46718417 A/T cg07012999 chr22:46692446 CN5H6.4;GTSE1 -0.47 -5.07 -0.3 7.63e-7 LDL cholesterol;Cholesterol, total; CESC cis rs863345 0.967 rs17630699 chr1:158463086 C/T cg12129480 chr1:158549410 OR10X1 0.31 6.12 0.35 3.37e-9 Pneumococcal bacteremia; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg22335246 chr12:120763591 PLA2G1B -0.48 -6.57 -0.37 2.69e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2302190 0.882 rs3744111 chr17:56607959 G/A cg25885038 chr17:56607967 SEPT4 -0.41 -5.61 -0.33 5.13e-8 Vitamin D levels; CESC cis rs524281 0.773 rs2236652 chr11:66002681 G/A cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.38e-7 Electroencephalogram traits; CESC cis rs6500395 1.000 rs9938633 chr16:48682093 G/C cg04672837 chr16:48644449 N4BP1 0.51 6.36 0.36 8.64e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs1371867 0.846 rs2439458 chr8:101297984 T/C cg11906718 chr8:101322791 RNF19A 0.46 5.91 0.34 1.03e-8 Atrioventricular conduction; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10825850 chr5:176944593 DDX41 -0.63 -7.57 -0.42 6.17e-13 Gut microbiome composition (summer); CESC cis rs4819052 0.851 rs2255774 chr21:46683851 A/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.56 7.66 0.43 3.41e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg03676636 chr4:99064102 C4orf37 0.33 5.12 0.3 5.93e-7 Colonoscopy-negative controls vs population controls; CESC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg04169830 chr2:88471460 THNSL2 0.35 5.38 0.31 1.65e-7 Response to metformin (IC50); CESC cis rs6540556 0.723 rs6672256 chr1:209894043 A/T cg05527609 chr1:210001259 C1orf107 0.55 5.86 0.34 1.34e-8 Red blood cell count; CESC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg11764359 chr7:65958608 NA -0.95 -14.12 -0.66 3.94e-34 Aortic root size; CESC cis rs4481887 0.927 rs4578248 chr1:248434069 G/A cg00666640 chr1:248458726 OR2T12 0.38 6.38 0.37 7.73e-10 Common traits (Other); CESC cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg24308560 chr3:49941425 MST1R 0.61 8.92 0.48 8e-17 Intelligence (multi-trait analysis); CESC cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg08847533 chr14:75593920 NEK9 0.93 17.1 0.72 1.07e-44 Height; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11674844 chr1:27216367 GPN2 -0.49 -6.2 -0.36 2.21e-9 Asthma; CESC cis rs62408225 1.000 rs2089126 chr6:90970212 A/G cg06866423 chr6:90926672 BACH2 0.43 5.13 0.3 5.61e-7 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC trans rs3008870 0.583 rs2147838 chr1:67399466 T/C cg19754094 chr2:74055942 STAMBP 0.62 6.0 0.35 6.49e-9 Lymphocyte percentage of white cells; CESC cis rs36051895 0.632 rs12340617 chr9:5164492 G/C cg02405213 chr9:5042618 JAK2 -0.54 -6.42 -0.37 6.43e-10 Pediatric autoimmune diseases; CESC trans rs35160687 0.644 rs10204589 chr2:86493223 A/G ch.2.2367852R chr2:113497768 CKAP2L -0.48 -6.1 -0.35 3.7e-9 Night sleep phenotypes; CESC cis rs782590 0.935 rs62165197 chr2:55801812 C/T cg18811423 chr2:55921094 PNPT1 0.8 12.91 0.62 6.32e-30 Metabolic syndrome; CESC cis rs6973256 0.605 rs6467499 chr7:133348922 G/T cg10665199 chr7:133106180 EXOC4 -0.43 -5.84 -0.34 1.52e-8 Intelligence (multi-trait analysis); CESC cis rs208520 1.000 rs12199876 chr6:66989469 A/G cg07460842 chr6:66804631 NA 0.89 10.18 0.53 9.11e-21 Exhaled nitric oxide output; CESC cis rs2012796 0.957 rs8011477 chr14:81815587 C/T cg02996355 chr14:81879375 NA 0.49 5.75 0.33 2.51e-8 Night sleep phenotypes; CESC cis rs6088590 1.000 rs6087626 chr20:33347328 C/T cg06115741 chr20:33292138 TP53INP2 0.59 7.32 0.41 2.95e-12 Coronary artery disease; CESC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg18758796 chr5:131593413 PDLIM4 0.48 6.97 0.39 2.55e-11 Acylcarnitine levels; CESC cis rs992157 0.735 rs12990082 chr2:219102332 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.69 9.55 0.51 8.88e-19 Colorectal cancer; CESC cis rs6793245 0.810 rs7429945 chr3:38591689 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.45 -5.91 -0.34 1.03e-8 QT interval; CESC cis rs2625529 0.938 rs2723343 chr15:72108269 C/T cg16672083 chr15:72433130 SENP8 -0.48 -5.68 -0.33 3.52e-8 Red blood cell count; CESC cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg05234568 chr11:5960015 NA -0.55 -6.41 -0.37 6.48e-10 DNA methylation (variation); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26339992 chr1:28241106 RPA2 -0.47 -6.04 -0.35 5.3e-9 Fibrinogen levels; CESC cis rs6137287 0.668 rs6047258 chr20:21098277 A/C cg13880779 chr20:21376337 NKX2-4 0.35 5.57 0.32 6.31e-8 Height; CESC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg04944784 chr2:26401820 FAM59B -0.65 -7.18 -0.4 6.92e-12 Gut microbiome composition (summer); CESC cis rs12477438 0.520 rs6743355 chr2:99732360 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.87 0.7 2.48e-40 Chronic sinus infection; CESC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.52 0.42 8.3e-13 Prudent dietary pattern; CESC cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg20891283 chr12:69753455 YEATS4 0.9 14.99 0.68 3.32e-37 Blood protein levels; CESC trans rs11039798 1.000 rs7125913 chr11:48984318 G/A cg15704280 chr7:45808275 SEPT13 0.71 6.65 0.38 1.7e-10 Axial length; CESC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg18016565 chr1:150552671 MCL1 0.33 5.14 0.3 5.34e-7 Tonsillectomy; CESC cis rs1569175 0.655 rs3115414 chr2:200913244 A/C cg19045956 chr2:200819837 C2orf60;C2orf47 0.64 5.41 0.32 1.44e-7 Response to treatment for acute lymphoblastic leukemia; CESC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg17724175 chr1:150552817 MCL1 0.42 6.34 0.36 1e-9 Melanoma; CESC cis rs17253792 0.915 rs75862063 chr14:56177769 G/T cg01858014 chr14:56050164 KTN1 -0.94 -7.27 -0.41 4.03e-12 Putamen volume; CESC cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg15017067 chr4:17643749 FAM184B 0.37 5.18 0.3 4.34e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs798766 0.953 rs13123646 chr4:1740539 T/C cg05874882 chr4:1763078 NA -0.58 -8.03 -0.44 3.23e-14 Bladder cancer;Urinary bladder cancer; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg14121103 chr3:43731973 ABHD5 0.5 7.41 0.41 1.69e-12 Systemic lupus erythematosus; CESC trans rs8029989 0.869 rs8039162 chr15:38740829 A/G cg05218311 chr11:79151791 ODZ4 0.37 6.12 0.35 3.3e-9 Psychosis (atypical); CESC cis rs16917546 1.000 rs10995258 chr10:64408787 C/T cg03961010 chr10:64397487 ZNF365 -0.37 -6.11 -0.35 3.55e-9 Basal cell carcinoma; CESC cis rs2180341 1.000 rs6937287 chr6:127645719 T/A cg24812749 chr6:127587940 RNF146 1.07 15.4 0.69 1.16e-38 Breast cancer; CESC cis rs6493487 0.512 rs71471523 chr15:51197324 G/A cg02338191 chr15:51200825 AP4E1 0.6 5.58 0.32 5.79e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs7208859 0.623 rs56095789 chr17:29060170 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg04317338 chr11:64019027 PLCB3 -0.79 -7.5 -0.42 9.5e-13 Mean platelet volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg00745463 chr17:30367425 LRRC37B 0.45 6.04 0.35 5.14e-9 Fibrinogen levels; CESC cis rs8044868 0.586 rs7200854 chr16:72083318 G/A cg01557791 chr16:72042693 DHODH -0.43 -5.89 -0.34 1.17e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs7662987 0.517 rs2924580 chr4:100032168 C/G cg12011299 chr4:100065546 ADH4 0.62 6.95 0.39 2.9e-11 Smoking initiation; CESC cis rs1401999 0.628 rs1520195 chr3:183736882 G/A cg01324343 chr3:183735012 ABCC5 0.55 10.8 0.55 8.98e-23 Anterior chamber depth; CESC cis rs10465746 0.725 rs6694752 chr1:84389960 C/T cg10977910 chr1:84465055 TTLL7 0.55 7.46 0.42 1.24e-12 Obesity-related traits; CESC cis rs2243480 1.000 rs778691 chr7:65873092 G/C cg18252515 chr7:66147081 NA -1.39 -14.18 -0.66 2.5e-34 Diabetic kidney disease; CESC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg19717773 chr7:2847554 GNA12 0.56 8.15 0.45 1.43e-14 Height; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19777992 chr5:52856773 NDUFS4 -0.56 -6.23 -0.36 1.84e-9 Gut microbiome composition (summer); CESC cis rs2996428 0.667 rs7511793 chr1:3744249 A/G cg13057898 chr1:3703894 LRRC47 0.45 6.19 0.36 2.29e-9 Red cell distribution width; CESC cis rs11683229 0.704 rs17850223 chr2:63283178 C/G cg17519650 chr2:63277830 OTX1 -0.73 -5.73 -0.33 2.71e-8 Protein quantitative trait loci; CESC cis rs9291683 0.530 rs882223 chr4:9981625 A/C cg11266682 chr4:10021025 SLC2A9 0.62 12.69 0.61 3.76e-29 Bone mineral density; CESC cis rs28647808 0.881 rs41316982 chr9:136259117 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.85 5.74 0.33 2.59e-8 Blood protein levels; CESC cis rs898097 0.528 rs2243523 chr17:80680449 G/T cg15369054 chr17:80825471 TBCD 0.38 5.52 0.32 8.04e-8 Breast cancer; CESC cis rs9486719 1.000 rs2179126 chr6:96871350 A/G cg18709589 chr6:96969512 KIAA0776 0.53 5.81 0.34 1.75e-8 Migraine;Coronary artery disease; CESC cis rs2370759 0.891 rs76164690 chr10:32590362 T/G cg18270830 chr10:32634957 EPC1 0.66 5.72 0.33 2.86e-8 Sexual dysfunction (female); CESC cis rs1355223 0.506 rs7130678 chr11:34869181 A/G cg11058730 chr11:34937778 PDHX;APIP -0.62 -8.06 -0.44 2.71e-14 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs897984 0.721 rs4889525 chr16:30989858 T/C cg00531865 chr16:30841666 NA 0.5 6.85 0.39 5.2e-11 Dementia with Lewy bodies; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg25536300 chr19:797459 PTBP1 -0.47 -6.15 -0.35 2.82e-9 Ulcerative colitis; CESC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg16132339 chr22:24313637 DDTL;DDT 0.38 5.72 0.33 2.83e-8 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg05564831 chr3:52568323 NT5DC2 0.44 6.69 0.38 1.33e-10 Bipolar disorder; CESC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg11987759 chr7:65425863 GUSB -0.48 -6.55 -0.37 3.04e-10 Aortic root size; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13134662 chr9:136858680 VAV2 -0.44 -6.48 -0.37 4.55e-10 Gambling; CESC cis rs832540 0.593 rs96844 chr5:56196604 G/A cg12311346 chr5:56204834 C5orf35 -0.45 -5.59 -0.32 5.61e-8 Coronary artery disease; CESC cis rs113835537 0.529 rs12099041 chr11:66232773 C/T cg24851651 chr11:66362959 CCS 0.46 5.68 0.33 3.57e-8 Airway imaging phenotypes; CESC cis rs1348850 0.914 rs7565022 chr2:178320222 A/T cg23306229 chr2:178417860 TTC30B 0.6 7.69 0.43 2.98e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs8077889 0.750 rs231539 chr17:41942109 T/C cg26893861 chr17:41843967 DUSP3 -0.82 -7.92 -0.44 6.7e-14 Triglycerides; CESC cis rs7927771 0.931 rs4752801 chr11:47907641 A/G cg05585544 chr11:47624801 NA -0.42 -6.79 -0.38 7.41e-11 Subjective well-being; CESC cis rs4450798 0.793 rs28541501 chr3:13757636 G/T cg05589046 chr3:13742034 LOC285375 0.36 5.63 0.33 4.69e-8 Bipolar disorder with mood-incongruent psychosis; CESC cis rs6570726 0.846 rs6919684 chr6:145883801 A/G cg05347473 chr6:146136440 FBXO30 0.51 6.63 0.38 1.82e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg26304593 chr6:42947056 PEX6 -0.42 -5.39 -0.31 1.56e-7 Alzheimer's disease in APOE e4+ carriers; CESC cis rs7131987 0.903 rs7970390 chr12:29398655 A/G cg09582351 chr12:29534625 ERGIC2 -0.34 -5.39 -0.31 1.57e-7 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00900124 chr2:69969033 ANXA4 0.53 6.21 0.36 1.99e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.2 0.3 4.06e-7 Colonoscopy-negative controls vs population controls; CESC cis rs2243480 1.000 rs73142162 chr7:65374296 A/T cg13147721 chr7:65941812 NA -0.88 -8.15 -0.45 1.5e-14 Diabetic kidney disease; CESC cis rs7631605 0.905 rs11717310 chr3:37175150 C/T cg22985146 chr3:37219077 LRRFIP2 -0.32 -5.2 -0.3 3.92e-7 Cerebrospinal P-tau181p levels; CESC cis rs2228479 0.850 rs2190808 chr16:89840856 C/T cg14709524 chr16:89940631 TCF25 0.91 6.74 0.38 1e-10 Skin colour saturation; CESC cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.07 0.3 7.65e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6060717 0.610 rs2244883 chr20:34620896 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.49 6.26 0.36 1.54e-9 Hip circumference adjusted for BMI; CESC cis rs8020095 0.528 rs13379476 chr14:67411733 T/C cg19548862 chr14:67692701 FAM71D -0.48 -5.86 -0.34 1.4e-8 Depression (quantitative trait); CESC cis rs533123 0.701 rs204054 chr1:29160462 T/C cg08366446 chr1:29138936 OPRD1 0.54 5.54 0.32 7.4e-8 Schizophrenia; CESC cis rs4595586 0.563 rs11169769 chr12:39233134 C/G cg26384229 chr12:38710491 ALG10B 0.68 10.21 0.53 7.67e-21 Morning vs. evening chronotype; CESC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg07507251 chr3:52567010 NT5DC2 0.32 5.78 0.33 2.15e-8 Electroencephalogram traits; CESC cis rs35146811 0.586 rs12705067 chr7:99594726 T/C cg22906224 chr7:99728672 NA 0.44 5.22 0.31 3.59e-7 Coronary artery disease; CESC cis rs4722166 0.573 rs35436671 chr7:22775508 G/A cg05265849 chr7:22767390 IL6 0.57 7.02 0.4 1.84e-11 Lung cancer; CESC cis rs116095464 0.681 rs9687745 chr5:229309 C/T cg10591111 chr5:226296 SDHA -0.54 -6.75 -0.38 9.52e-11 Breast cancer; CESC cis rs1832871 0.711 rs9459829 chr6:158680799 C/T cg07165851 chr6:158734300 TULP4 0.59 6.36 0.36 8.84e-10 Height; CESC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.73 -0.33 2.78e-8 Total body bone mineral density; CESC cis rs17253792 0.732 rs10146604 chr14:56045770 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.81 5.95 0.34 8.68e-9 Putamen volume; CESC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg24209194 chr3:40518798 ZNF619 0.49 6.15 0.35 2.83e-9 Renal cell carcinoma; CESC cis rs4728302 0.869 rs958404 chr7:133597186 G/T cg10665199 chr7:133106180 EXOC4 -0.45 -6.22 -0.36 1.88e-9 Intelligence;Intelligence (multi-trait analysis); CESC cis rs4843747 0.605 rs28399183 chr16:88107277 G/A cg06374794 chr16:88002281 BANP 0.39 5.14 0.3 5.43e-7 Menopause (age at onset); CESC trans rs61931739 0.929 rs1844524 chr12:34094709 A/T cg26384229 chr12:38710491 ALG10B -0.47 -6.61 -0.38 2.07e-10 Morning vs. evening chronotype; CESC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg08888203 chr3:10149979 C3orf24 0.48 6.24 0.36 1.72e-9 Alzheimer's disease; CESC cis rs36051895 0.632 rs57698263 chr9:5143262 G/A cg02405213 chr9:5042618 JAK2 -0.5 -6.28 -0.36 1.39e-9 Pediatric autoimmune diseases; CESC cis rs11098499 0.865 rs28845498 chr4:120405186 G/A cg09307838 chr4:120376055 NA 0.93 13.07 0.63 1.78e-30 Corneal astigmatism; CESC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.22 0.45 9.28e-15 Menopause (age at onset); CESC cis rs1927790 0.727 rs9556551 chr13:96947223 T/A cg02571835 chr13:96230311 CLDN10 -0.36 -5.35 -0.31 1.88e-7 Body mass index; CESC cis rs2732480 0.577 rs2634680 chr12:48734564 T/C cg04545296 chr12:48745243 ZNF641 0.43 7.15 0.4 8.63e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs7923609 0.967 rs7915779 chr10:65244244 G/C cg01631684 chr10:65280961 REEP3 -0.43 -5.4 -0.31 1.47e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg01475735 chr3:40494733 NA -0.41 -5.22 -0.31 3.64e-7 Renal cell carcinoma; CESC cis rs4654899 0.758 rs6693055 chr1:21421813 C/T cg05370193 chr1:21551575 ECE1 0.36 5.47 0.32 1.02e-7 Superior frontal gyrus grey matter volume; CESC cis rs9611519 0.894 rs13053242 chr22:41459486 G/A cg03806693 chr22:41940476 POLR3H -0.57 -5.96 -0.34 7.83e-9 Neuroticism; CESC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg16049864 chr8:95962084 TP53INP1 0.52 7.88 0.44 8.64e-14 Type 2 diabetes; CESC cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg24209194 chr3:40518798 ZNF619 0.51 6.64 0.38 1.74e-10 Renal cell carcinoma; CESC cis rs1443512 0.812 rs4759058 chr12:54339052 C/A cg17410650 chr12:54324560 NA -0.47 -7.79 -0.43 1.54e-13 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CESC cis rs4803468 0.905 rs284662 chr19:41932275 T/C cg08639244 chr19:41945921 ATP5SL -0.47 -5.66 -0.33 3.84e-8 Height; CESC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg18402987 chr7:1209562 NA 0.46 6.11 0.35 3.57e-9 Longevity;Endometriosis; CESC cis rs7296418 0.636 rs11057261 chr12:123797567 T/C cg05973401 chr12:123451056 ABCB9 0.43 5.46 0.32 1.07e-7 Platelet count; CESC cis rs2985684 0.948 rs12886130 chr14:50082753 T/C cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.48 -5.7 -0.33 3.12e-8 Carotid intima media thickness; CESC cis rs7264396 0.563 rs6060592 chr20:34352414 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.86 -10.2 -0.53 7.89e-21 Total cholesterol levels; CESC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg04518342 chr5:131593106 PDLIM4 -0.36 -5.27 -0.31 2.88e-7 Breast cancer; CESC cis rs17401966 0.838 rs4623 chr1:10366692 C/G cg15208524 chr1:10270712 KIF1B 0.43 5.5 0.32 8.98e-8 Hepatocellular carcinoma; CESC cis rs2204008 0.805 rs4882575 chr12:37940573 G/A cg26384229 chr12:38710491 ALG10B -0.53 -7.52 -0.42 8.68e-13 Bladder cancer; CESC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg16049864 chr8:95962084 TP53INP1 -0.59 -9.94 -0.52 5.23e-20 Type 2 diabetes; CESC cis rs3820928 0.605 rs6718767 chr2:227800776 A/G cg11843606 chr2:227700838 RHBDD1 -0.56 -7.96 -0.44 4.9e-14 Pulmonary function; CESC cis rs1595825 0.891 rs16823148 chr2:198584209 G/A cg00982548 chr2:198649783 BOLL -0.52 -5.71 -0.33 3.1e-8 Ulcerative colitis; CESC trans rs208520 0.690 rs207112 chr6:66792092 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -12.83 -0.62 1.2e-29 Exhaled nitric oxide output; CESC cis rs6460942 0.591 rs75804221 chr7:12364319 C/T cg06484146 chr7:12443880 VWDE -0.64 -6.99 -0.39 2.27e-11 Coronary artery disease; CESC cis rs11649653 0.502 rs62057232 chr16:30820866 T/C cg02466173 chr16:30829666 NA 0.44 6.81 0.39 6.43e-11 Triglycerides; CESC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg14298792 chr15:30685198 CHRFAM7A 0.46 5.54 0.32 7.38e-8 Huntington's disease progression; CESC cis rs4901869 0.966 rs12878614 chr14:59339477 A/C cg02291164 chr14:59296302 NA 0.45 7.78 0.43 1.6e-13 Panic disorder; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg19250764 chr7:66461952 TYW1;SBDS -0.45 -6.38 -0.36 7.94e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs965469 0.947 rs1854834 chr20:3376619 C/T cg25506879 chr20:3388711 C20orf194 -0.57 -6.12 -0.35 3.38e-9 IFN-related cytopenia; CESC cis rs4728302 0.807 rs10226267 chr7:133601862 G/A cg10665199 chr7:133106180 EXOC4 0.42 5.84 0.34 1.56e-8 Intelligence;Intelligence (multi-trait analysis); CESC cis rs6121246 0.647 rs6088855 chr20:30225792 C/T cg13852791 chr20:30311386 BCL2L1 0.7 7.13 0.4 9.75e-12 Mean corpuscular hemoglobin; CESC trans rs7618501 1.000 rs7372725 chr3:49790544 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -8.49 -0.46 1.55e-15 Intelligence (multi-trait analysis); CESC cis rs2841277 0.509 rs11850949 chr14:105408827 A/C cg14403583 chr14:105418241 AHNAK2 -0.61 -8.36 -0.46 3.59e-15 Rheumatoid arthritis; CESC cis rs6087990 0.669 rs2424929 chr20:31389518 A/G cg13636640 chr20:31349939 DNMT3B 0.79 12.92 0.62 6.22e-30 Ulcerative colitis; CESC trans rs3780486 0.846 rs10813954 chr9:33137596 A/C cg04842962 chr6:43655489 MRPS18A 1.0 19.15 0.76 6.75e-52 IgG glycosylation; CESC cis rs524281 0.773 rs2236651 chr11:66001418 C/T cg14036092 chr11:66035641 RAB1B -0.53 -5.31 -0.31 2.38e-7 Electroencephalogram traits; CESC cis rs7216064 1.000 rs12451707 chr17:65871598 G/A cg07042672 chr17:66097459 LOC651250 -0.53 -5.45 -0.32 1.14e-7 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs10489525 0.599 rs2335724 chr1:115608444 T/C cg12756093 chr1:115239321 AMPD1 -0.43 -5.35 -0.31 1.94e-7 Autism; CESC cis rs7216064 1.000 rs62084214 chr17:65843325 C/G cg07042672 chr17:66097459 LOC651250 -0.54 -5.67 -0.33 3.73e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs815815 0.608 rs815809 chr2:47380203 T/C cg27223769 chr2:47403360 CALM2 -0.48 -5.55 -0.32 6.82e-8 Dialysis-related mortality; CESC cis rs2737618 0.651 rs2248967 chr1:200084893 A/G cg21825944 chr1:200113062 NR5A2 0.44 6.87 0.39 4.64e-11 Uric acid levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06688875 chr20:1424325 NSFL1C -0.65 -7.7 -0.43 2.64e-13 Gut microbiome composition (summer); CESC cis rs1372520 0.684 rs2583968 chr4:90745395 C/G cg15133208 chr4:90757351 SNCA -0.39 -5.23 -0.31 3.44e-7 Neuroticism; CESC cis rs1348850 0.567 rs3770012 chr2:178538023 A/G cg23306229 chr2:178417860 TTC30B -0.53 -6.5 -0.37 3.94e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1568889 1.000 rs12796293 chr11:28177723 C/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.76 -10.36 -0.54 2.5e-21 Bipolar disorder; CESC cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg20503657 chr10:835505 NA 0.82 8.47 0.46 1.66e-15 Eosinophil percentage of granulocytes; CESC cis rs1808579 0.935 rs2435307 chr18:21127910 A/G cg14672496 chr18:21087552 C18orf8 -0.38 -5.74 -0.33 2.62e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg11502198 chr6:26597334 ABT1 0.53 5.43 0.32 1.26e-7 Intelligence (multi-trait analysis); CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg07092213 chr7:1199455 ZFAND2A -0.45 -6.05 -0.35 4.97e-9 Longevity;Endometriosis; CESC cis rs1348850 0.789 rs13027959 chr2:178275887 G/A cg22681709 chr2:178499509 PDE11A -0.4 -6.03 -0.35 5.36e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.8 8.82 0.48 1.62e-16 Alzheimer's disease; CESC cis rs6575793 1.000 rs7141087 chr14:101036052 T/C cg18516195 chr14:101012996 BEGAIN 0.46 6.38 0.36 7.77e-10 Menarche (age at onset); CESC cis rs7918232 0.698 rs6482586 chr10:27297829 A/C cg14240646 chr10:27532245 ACBD5 -0.49 -5.26 -0.31 2.91e-7 Breast cancer; CESC cis rs2637266 0.935 rs7918777 chr10:78394375 A/G cg18941641 chr10:78392320 NA 0.45 8.6 0.47 6.93e-16 Pulmonary function; CESC cis rs11640734 0.619 rs2293586 chr16:89962394 A/G cg06558623 chr16:89946397 TCF25 0.54 5.29 0.31 2.61e-7 Interleukin-17 levels; CESC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 6.23 0.36 1.78e-9 Bipolar disorder; CESC cis rs3008870 0.583 rs11208978 chr1:67442210 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -11.11 -0.56 8.58e-24 Lymphocyte percentage of white cells; CESC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.57 7.45 0.42 1.32e-12 Prudent dietary pattern; CESC cis rs2859741 0.587 rs580029 chr1:37471609 C/A cg09363841 chr1:37513479 NA -0.48 -6.6 -0.38 2.27e-10 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CESC cis rs826838 0.586 rs10785554 chr12:38628749 T/A cg26384229 chr12:38710491 ALG10B 0.47 6.93 0.39 3.18e-11 Heart rate; CESC cis rs672059 0.548 rs607332 chr1:183253213 G/A ch.1.3577855R chr1:183094577 LAMC1 -0.5 -5.9 -0.34 1.1e-8 Hypertriglyceridemia; CESC cis rs12950390 0.853 rs11658511 chr17:45856918 T/C cg00777063 chr17:45855553 NA -0.39 -5.77 -0.33 2.26e-8 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03044510 chr21:27107978 ATP5J;GABPA 0.56 6.25 0.36 1.65e-9 Gut microbiome composition (summer); CESC cis rs2952156 0.959 rs1495102 chr17:37832093 T/C cg20243544 chr17:37824526 PNMT 0.6 7.38 0.41 2.01e-12 Asthma; CESC cis rs56399783 0.803 rs7811164 chr7:2822416 G/A cg19731401 chr7:2775893 GNA12 0.6 5.6 0.33 5.4e-8 Childhood ear infection; CESC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg23590916 chr17:43697445 MGC57346 0.65 6.48 0.37 4.51e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs7481584 1.000 rs3814964 chr11:2999507 G/T cg25174290 chr11:3078921 CARS -0.45 -5.54 -0.32 7.47e-8 Calcium levels; CESC cis rs2073300 0.609 rs6137927 chr20:23372513 A/G cg16736954 chr20:23401023 NAPB 0.8 6.25 0.36 1.67e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs6460942 0.591 rs4721079 chr7:12337742 A/G cg06484146 chr7:12443880 VWDE -0.63 -7.02 -0.4 1.91e-11 Coronary artery disease; CESC cis rs7246657 0.943 rs35540940 chr19:38008235 G/A cg23950597 chr19:37808831 NA -0.6 -6.18 -0.35 2.42e-9 Coronary artery calcification; CESC cis rs950776 0.518 rs952215 chr15:78819153 C/T cg24631222 chr15:78858424 CHRNA5 0.41 5.2 0.3 3.99e-7 Sudden cardiac arrest; CESC cis rs4699052 0.625 rs10212959 chr4:104300935 C/G cg16532752 chr4:104119610 CENPE 0.4 5.68 0.33 3.48e-8 Testicular germ cell tumor; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12994003 chr1:225616475 LBR -0.55 -6.29 -0.36 1.29e-9 Gut microbiome composition (summer); CESC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg14926445 chr8:58193284 C8orf71 -0.51 -5.47 -0.32 1.03e-7 Developmental language disorder (linguistic errors); CESC cis rs55883249 1.000 rs62119429 chr2:9743585 G/C cg23886495 chr2:9695866 ADAM17 0.61 5.52 0.32 8.11e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CESC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -10.21 -0.53 7.18e-21 Extrinsic epigenetic age acceleration; CESC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.4 5.03 0.3 8.97e-7 Tonsillectomy; CESC cis rs3806843 0.868 rs2563281 chr5:140131219 T/A cg26395211 chr5:140044315 WDR55 0.39 5.09 0.3 6.79e-7 Depressive symptoms (multi-trait analysis); CESC cis rs9527 0.590 rs12785223 chr10:104844011 C/T cg04362960 chr10:104952993 NT5C2 -0.43 -5.41 -0.32 1.41e-7 Arsenic metabolism; CESC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg08859206 chr1:53392774 SCP2 0.56 7.11 0.4 1.1e-11 Monocyte count; CESC trans rs11250097 0.535 rs11250086 chr8:10769783 A/G cg15556689 chr8:8085844 FLJ10661 -0.55 -6.72 -0.38 1.13e-10 Neuroticism; CESC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.48 6.05 0.35 4.97e-9 Tonsillectomy; CESC cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg22875332 chr1:76189707 ACADM 0.66 7.81 0.43 1.31e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11148252 0.532 rs9526975 chr13:53255804 C/T cg00495681 chr13:53174319 NA 0.63 8.41 0.46 2.55e-15 Lewy body disease; CESC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg07395648 chr5:131743802 NA -0.42 -5.26 -0.31 2.93e-7 Breast cancer;Mosquito bite size; CESC cis rs9815354 0.812 rs73071222 chr3:41986896 C/T cg03022575 chr3:42003672 ULK4 0.68 6.1 0.35 3.75e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7833986 0.501 rs72653962 chr8:56997505 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.54 0.42 7.58e-13 Height; CESC cis rs965469 1.000 rs6037533 chr20:3268817 T/C cg25506879 chr20:3388711 C20orf194 -0.55 -5.96 -0.34 7.97e-9 IFN-related cytopenia; CESC cis rs2797685 1.000 rs2797685 chr1:7879063 C/T cg04725166 chr1:7887271 PER3 -0.45 -6.24 -0.36 1.72e-9 Crohn's disease; CESC cis rs2635047 0.565 rs2571004 chr18:44710302 T/A cg24371990 chr18:44770781 NA 0.32 5.15 0.3 5.03e-7 Educational attainment; CESC cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg05340658 chr4:99064831 C4orf37 0.83 12.92 0.62 5.96e-30 Colonoscopy-negative controls vs population controls; CESC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg23708337 chr7:1209742 NA 0.48 5.4 0.31 1.46e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs74781061 0.858 rs58473469 chr15:74885063 C/T cg17294928 chr15:75287854 SCAMP5 -0.49 -5.09 -0.3 6.74e-7 Endometriosis; CESC cis rs1348850 0.958 rs1548067 chr2:178462914 C/T cg23306229 chr2:178417860 TTC30B 0.54 7.19 0.4 6.5e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs4588572 0.686 rs4470742 chr5:77657957 T/G cg11547950 chr5:77652471 NA 0.46 5.81 0.34 1.76e-8 Triglycerides; CESC cis rs7223966 1.000 rs7223412 chr17:61808172 T/C cg11494091 chr17:61959527 GH2 0.38 5.19 0.3 4.28e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.42 8.36 0.46 3.6e-15 Electroencephalogram traits; CESC cis rs7264396 0.623 rs2590984 chr20:34597031 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.49 5.71 0.33 2.98e-8 Total cholesterol levels; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg04309227 chr1:26561027 CCDC21 -0.44 -6.21 -0.36 2.02e-9 Gambling; CESC cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg25554036 chr4:6271136 WFS1 0.49 7.87 0.44 8.81e-14 Type 2 diabetes and other traits;Type 2 diabetes; CESC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg25072359 chr17:41440525 NA 0.44 5.91 0.34 1.06e-8 Menopause (age at onset); CESC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg22920501 chr2:26401640 FAM59B 0.78 8.6 0.47 7.14e-16 Gut microbiome composition (summer); CESC cis rs5167 0.525 rs11083752 chr19:45454363 G/A cg09555818 chr19:45449301 APOC2 0.41 6.54 0.37 3.08e-10 Blood protein levels; CESC cis rs116095464 0.614 rs28736753 chr5:274081 G/A cg08858540 chr5:346238 AHRR 0.41 5.06 0.3 7.93e-7 Breast cancer; CESC trans rs7095944 0.614 rs4962697 chr10:126447545 G/C cg27222157 chr11:66382978 RBM14 0.38 6.11 0.35 3.57e-9 Asthma; CESC cis rs2882667 0.861 rs11242445 chr5:138417054 G/T cg04439458 chr5:138467593 SIL1 -0.3 -5.1 -0.3 6.45e-7 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg16743903 chr16:89593216 SPG7 -0.43 -5.62 -0.33 4.87e-8 Multiple myeloma (IgH translocation); CESC cis rs55794721 0.509 rs2982358 chr1:25745204 G/T cg02931644 chr1:25747376 RHCE 0.39 6.52 0.37 3.6e-10 Plateletcrit;Mean corpuscular volume; CESC cis rs1879734 0.636 rs4927031 chr1:54183191 C/T cg23596471 chr1:54105337 GLIS1 0.31 5.06 0.3 7.86e-7 Mitral valve prolapse; CESC cis rs12545109 0.775 rs10093388 chr8:57318799 C/T cg09654669 chr8:57350985 NA -0.61 -8.25 -0.45 7.67e-15 Obesity-related traits; CESC cis rs863345 0.625 rs12119672 chr1:158500285 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.41e-11 Pneumococcal bacteremia; CESC cis rs7918232 0.882 rs788237 chr10:27457932 C/T cg14240646 chr10:27532245 ACBD5 0.68 6.43 0.37 5.91e-10 Breast cancer; CESC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg23172400 chr8:95962367 TP53INP1 0.4 7.48 0.42 1.1e-12 Type 2 diabetes; CESC trans rs60380162 0.928 rs1411705 chr1:87728263 C/G cg20163645 chr8:1900353 ARHGEF10 0.43 6.02 0.35 5.85e-9 Loneliness (linear analysis); CESC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg00149659 chr3:10157352 C3orf10 0.74 9.14 0.49 1.63e-17 Alzheimer's disease; CESC cis rs7254114 0.578 rs3745682 chr19:11313256 C/T cg02815516 chr19:11306319 KANK2 -0.44 -7.13 -0.4 9.68e-12 Immature fraction of reticulocytes; CESC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg18904891 chr8:8559673 CLDN23 0.65 7.59 0.42 5.56e-13 Obesity-related traits; CESC cis rs2228479 0.850 rs62056066 chr16:89906563 G/A cg04013166 chr16:89971882 TCF25 0.72 5.75 0.33 2.41e-8 Skin colour saturation; CESC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg25767906 chr1:53392781 SCP2 0.39 5.24 0.31 3.31e-7 Monocyte count; CESC cis rs9399135 0.967 rs7741626 chr6:135314182 C/T cg24558204 chr6:135376177 HBS1L 0.53 7.28 0.41 3.85e-12 Red blood cell count; CESC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg00933542 chr6:150070202 PCMT1 0.29 5.06 0.3 7.67e-7 Lung cancer; CESC cis rs709400 1.000 rs709400 chr14:104149475 A/G cg24130564 chr14:104152367 KLC1 -0.43 -5.48 -0.32 9.93e-8 Body mass index; CESC cis rs7107174 1.000 rs2512546 chr11:77957276 T/C cg02023728 chr11:77925099 USP35 0.43 6.11 0.35 3.48e-9 Testicular germ cell tumor; CESC cis rs765787 0.530 rs12440238 chr15:45512905 T/C cg24006582 chr15:45444508 DUOX1 0.52 6.32 0.36 1.13e-9 Uric acid levels; CESC cis rs7243790 0.777 rs3826583 chr18:51932991 G/A cg04730925 chr18:51795821 POLI -0.41 -5.3 -0.31 2.46e-7 Diastolic blood pressure; CESC cis rs1048238 0.506 rs848210 chr1:16259813 A/G cg22431228 chr1:16359049 CLCNKA 0.35 6.07 0.35 4.47e-9 Systolic blood pressure; CESC cis rs11122272 0.701 rs2883799 chr1:231531166 C/G cg06096015 chr1:231504339 EGLN1 0.43 6.15 0.35 2.9e-9 Hemoglobin concentration; CESC cis rs7937682 1.000 rs7121011 chr11:111568681 C/T cg09085632 chr11:111637200 PPP2R1B 1.03 14.07 0.65 5.86e-34 Primary sclerosing cholangitis; CESC trans rs6572548 0.504 rs1956082 chr14:49665496 A/C cg13412003 chr19:35455007 ZNF792 0.52 6.0 0.35 6.51e-9 Subjective well-being; CESC cis rs9611565 0.570 rs12159188 chr22:42121125 A/T cg06634786 chr22:41940651 POLR3H 0.52 5.53 0.32 7.55e-8 Vitiligo; CESC cis rs7503807 0.935 rs62068348 chr17:78608575 T/C cg09596252 chr17:78655493 RPTOR 0.49 7.21 0.4 5.93e-12 Obesity; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg10586903 chr19:41221192 ADCK4 -0.43 -6.03 -0.35 5.58e-9 Gambling; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11321298 chr22:40766510 SGSM3 -0.49 -6.55 -0.37 3.04e-10 Asthma; CESC cis rs11122272 0.735 rs2247132 chr1:231493359 G/A cg06096015 chr1:231504339 EGLN1 0.46 6.77 0.38 8.33e-11 Hemoglobin concentration; CESC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg18758796 chr5:131593413 PDLIM4 0.43 5.77 0.33 2.25e-8 Acylcarnitine levels; CESC trans rs10862688 0.716 rs7316185 chr12:83862134 G/T cg25858261 chr10:12085058 UPF2 -0.42 -6.0 -0.35 6.3e-9 Vertical cup-disc ratio; CESC cis rs2286503 0.752 rs2286504 chr7:22854847 G/T cg11367502 chr7:22862612 TOMM7 0.39 5.14 0.3 5.45e-7 Fibrinogen; CESC cis rs2242194 0.816 rs11264296 chr1:154994750 T/C cg06221963 chr1:154839813 KCNN3 -0.38 -5.71 -0.33 3.04e-8 Schizophrenia; CESC cis rs4595586 0.545 rs12819186 chr12:39356912 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.63 0.42 4.31e-13 Morning vs. evening chronotype; CESC cis rs2066819 1.000 rs2695782 chr12:56722830 C/T cg26734620 chr12:56694298 CS -0.94 -8.74 -0.47 2.67e-16 Psoriasis vulgaris; CESC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.47 6.59 0.38 2.33e-10 Bipolar disorder; CESC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg09699651 chr6:150184138 LRP11 0.41 5.14 0.3 5.46e-7 Lung cancer; CESC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg26441486 chr22:50317300 CRELD2 0.41 5.22 0.31 3.7e-7 Schizophrenia; CESC cis rs12530845 1.000 rs4291211 chr7:135335373 C/T cg23117316 chr7:135346802 PL-5283 -0.43 -5.44 -0.32 1.24e-7 Red blood cell traits; CESC cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg00409905 chr10:38381863 ZNF37A -0.45 -6.0 -0.35 6.52e-9 Extrinsic epigenetic age acceleration; CESC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg15112475 chr7:1198522 ZFAND2A -0.39 -6.16 -0.35 2.7e-9 Longevity;Endometriosis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03607946 chr20:34203965 SPAG4 -0.45 -6.01 -0.35 6.09e-9 Asthma; CESC cis rs77741769 0.571 rs10849807 chr12:121314056 T/C cg02419362 chr12:121203948 SPPL3 0.34 5.58 0.32 5.97e-8 Mean corpuscular volume; CESC trans rs9951602 0.512 rs4799248 chr18:76653459 G/A cg02800362 chr5:177631904 HNRNPAB 0.65 8.6 0.47 7.27e-16 Obesity-related traits; CESC cis rs17253792 0.822 rs12100949 chr14:56040787 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.81 6.32 0.36 1.08e-9 Putamen volume; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03228602 chr6:7888995 TXNDC5 0.51 6.64 0.38 1.81e-10 Fibrinogen levels; CESC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg24531977 chr5:56204891 C5orf35 0.7 9.46 0.5 1.71e-18 Initial pursuit acceleration; CESC cis rs250677 0.522 rs2217638 chr5:148364355 A/G cg18129178 chr5:148520854 ABLIM3 0.46 5.07 0.3 7.47e-7 Breast cancer; CESC cis rs7808935 0.768 rs757138 chr7:27989403 T/G cg05786569 chr7:27702416 HIBADH 0.42 5.24 0.31 3.2e-7 Prostate cancer; CESC cis rs2795502 1.000 rs3121278 chr10:43375646 G/T cg20628663 chr10:43360327 NA 0.54 5.67 0.33 3.66e-8 Blood protein levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13300911 chr15:42119951 JMJD7;MAPKBP1;JMJD7-PLA2G4B -0.57 -6.68 -0.38 1.44e-10 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26468274 chr6:43544000 XPO5;POLH 0.57 6.42 0.37 6.43e-10 Gut microbiome composition (summer); CESC cis rs2073300 1.000 rs79255223 chr20:23443559 G/T cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg21285383 chr16:89894308 SPIRE2 0.28 5.08 0.3 7.09e-7 Vitiligo; CESC cis rs9902453 0.765 rs2264303 chr17:28055348 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.77 -10.33 -0.54 3.03e-21 Coffee consumption (cups per day); CESC trans rs453301 0.571 rs330048 chr8:9087278 A/C cg06636001 chr8:8085503 FLJ10661 -0.52 -6.74 -0.38 1.01e-10 Joint mobility (Beighton score); CESC cis rs9399135 0.967 rs34546690 chr6:135369709 T/C cg22676075 chr6:135203613 NA 0.52 7.32 0.41 2.89e-12 Red blood cell count; CESC cis rs10779751 0.770 rs2275527 chr1:11190646 A/G cg08854313 chr1:11322531 MTOR 0.68 8.16 0.45 1.37e-14 Body mass index; CESC cis rs10771431 0.967 rs7137443 chr12:9372029 C/T cg00504896 chr12:9437009 LOC642846 -0.41 -5.44 -0.32 1.19e-7 Breast size; CESC cis rs4836694 0.574 rs4837476 chr9:132937533 T/C cg05251000 chr9:132935664 FREQ 0.42 5.64 0.33 4.33e-8 Alzheimer's disease (cognitive decline); CESC cis rs17433780 0.836 rs61798917 chr1:89506093 G/A cg09516651 chr1:89888402 LOC400759 0.66 9.66 0.51 4.07e-19 Carotid intima media thickness; CESC cis rs6088590 1.000 rs2236270 chr20:33523155 G/T cg08999081 chr20:33150536 PIGU 0.58 8.49 0.46 1.46e-15 Coronary artery disease; CESC cis rs1348850 0.872 rs7559521 chr2:178452328 A/G cg23306229 chr2:178417860 TTC30B -0.45 -5.66 -0.33 4.01e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -9.36 -0.5 3.67e-18 Alzheimer's disease; CESC cis rs11166629 1.000 rs4909332 chr8:135646340 T/C cg27224718 chr8:135614730 ZFAT 0.54 6.74 0.38 9.99e-11 Smoking quantity; CESC cis rs6032067 0.777 rs34163611 chr20:43778990 T/C cg10761708 chr20:43804764 PI3 0.53 6.27 0.36 1.48e-9 Blood protein levels; CESC cis rs1983891 0.909 rs4714482 chr6:41528199 G/A cg20194872 chr6:41519635 FOXP4 0.56 8.09 0.45 2.16e-14 Prostate cancer; CESC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.36 -5.86 -0.34 1.4e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs11098499 0.863 rs1383532 chr4:120434404 A/T cg24375607 chr4:120327624 NA -0.42 -5.1 -0.3 6.6e-7 Corneal astigmatism; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg06361278 chr17:25783929 NA -0.48 -6.29 -0.36 1.29e-9 Ulcerative colitis; CESC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg12419862 chr22:24373484 LOC391322 -0.7 -9.66 -0.51 4.02e-19 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs17253792 0.822 rs10083303 chr14:56068521 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs829883 0.867 rs1641640 chr12:98896017 A/G cg25150519 chr12:98850993 NA 0.71 9.74 0.51 2.31e-19 Colorectal adenoma (advanced); CESC cis rs9660992 0.573 rs12140703 chr1:205182865 G/C cg00857998 chr1:205179979 DSTYK 0.54 6.73 0.38 1.06e-10 Mean corpuscular volume;Mean platelet volume; CESC cis rs6696846 0.765 rs61822568 chr1:205081166 C/G cg00857998 chr1:205179979 DSTYK 0.54 7.12 0.4 9.98e-12 Red blood cell count; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg02654935 chr6:12514489 NA -0.41 -6.11 -0.35 3.54e-9 Gut microbiota (bacterial taxa); CESC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg08859206 chr1:53392774 SCP2 -0.64 -8.55 -0.47 9.9e-16 Monocyte count; CESC trans rs931812 0.757 rs4734015 chr8:101909258 C/G cg20993868 chr7:22813445 NA 0.42 6.48 0.37 4.38e-10 Attention deficit hyperactivity disorder and conduct disorder; CESC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.21 0.57 3.99e-24 Alzheimer's disease; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20898078 chr7:150773226 SLC4A2 0.49 6.62 0.38 1.97e-10 Fibrinogen levels; CESC cis rs72781680 0.699 rs72794291 chr2:23897935 C/T cg20701182 chr2:24300061 SF3B14 0.81 7.06 0.4 1.5e-11 Lymphocyte counts; CESC cis rs11750568 1.000 rs1136377 chr5:178513141 C/T cg10208897 chr5:178548229 ADAMTS2 0.39 5.45 0.32 1.15e-7 Height; CESC cis rs9611565 0.765 rs132920 chr22:41810170 T/C cg06634786 chr22:41940651 POLR3H 0.71 7.47 0.42 1.16e-12 Vitiligo; CESC cis rs1538970 0.924 rs11211111 chr1:45908782 C/T cg06784218 chr1:46089804 CCDC17 0.35 5.54 0.32 7.26e-8 Platelet count; CESC cis rs60843830 0.550 rs300751 chr2:209063 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.48 6.09 0.35 3.91e-9 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs2243480 1.000 rs6964245 chr7:65718717 G/A cg13147721 chr7:65941812 NA 0.98 9.24 0.49 8.25e-18 Diabetic kidney disease; CESC cis rs2637266 0.655 rs7902535 chr10:78460889 C/T cg18941641 chr10:78392320 NA 0.42 7.53 0.42 7.81e-13 Pulmonary function; CESC cis rs6800768 0.663 rs62253424 chr3:24093919 C/A cg10674438 chr3:24145617 LOC152024 -0.4 -5.48 -0.32 1.01e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.94 14.0 0.65 1.02e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs2933343 0.700 rs2630257 chr3:128644015 T/C cg24203234 chr3:128598194 ACAD9 0.43 5.8 0.34 1.93e-8 IgG glycosylation; CESC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg23708337 chr7:1209742 NA 0.55 5.47 0.32 1.04e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs6582630 0.519 rs11181998 chr12:38439970 C/A cg13010199 chr12:38710504 ALG10B 0.46 6.0 0.35 6.56e-9 Drug-induced liver injury (flucloxacillin); CESC cis rs9814567 1.000 rs1357762 chr3:134264859 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.43 -5.85 -0.34 1.42e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs1577917 1.000 rs12205336 chr6:86722367 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.17 -0.35 2.58e-9 Response to antipsychotic treatment; CESC cis rs8114671 0.935 rs35193912 chr20:33785050 C/T cg06115741 chr20:33292138 TP53INP2 -0.42 -5.11 -0.3 6.06e-7 Height; CESC cis rs2243480 1.000 rs2257790 chr7:65600450 C/T cg13147721 chr7:65941812 NA -0.95 -9.01 -0.48 4.12e-17 Diabetic kidney disease; CESC cis rs2290159 0.800 rs3730269 chr3:12653233 G/T cg23032965 chr3:12705835 RAF1 0.54 5.86 0.34 1.35e-8 Cholesterol, total; CESC cis rs9309473 1.000 rs11901272 chr2:73720444 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.12 -0.35 3.42e-9 Metabolite levels; CESC cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg03060546 chr3:49711283 APEH 0.55 6.66 0.38 1.6e-10 Parkinson's disease; CESC cis rs3768617 0.510 rs4651140 chr1:183096952 G/T ch.1.3577855R chr1:183094577 LAMC1 0.89 14.39 0.66 4.39e-35 Fuchs's corneal dystrophy; CESC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg11764359 chr7:65958608 NA 0.97 15.48 0.69 6.16e-39 Aortic root size; CESC cis rs17401966 0.931 rs3748579 chr1:10420937 C/T cg15208524 chr1:10270712 KIF1B 0.4 5.12 0.3 6e-7 Hepatocellular carcinoma; CESC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg03467027 chr4:99064603 C4orf37 0.47 5.98 0.34 7.19e-9 Colonoscopy-negative controls vs population controls; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg07050647 chr2:122287957 CLASP1;RNU4ATAC -0.48 -6.07 -0.35 4.48e-9 Ulcerative colitis; CESC cis rs3768617 1.000 rs12026314 chr1:183104527 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 9.62 0.51 5.56e-19 Fuchs's corneal dystrophy; CESC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg27170947 chr2:26402098 FAM59B 0.87 9.89 0.52 7.6e-20 Gut microbiome composition (summer); CESC cis rs9616064 0.889 rs5767287 chr22:46996179 G/A cg05621596 chr22:47072043 GRAMD4 -0.49 -6.97 -0.39 2.58e-11 Urate levels in obese individuals; CESC cis rs6460942 0.555 rs7803268 chr7:12306793 G/A cg02935154 chr7:12443704 VWDE -0.59 -5.9 -0.34 1.11e-8 Coronary artery disease; CESC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg09658497 chr7:2847517 GNA12 -0.35 -5.09 -0.3 6.67e-7 Height; CESC cis rs1797885 0.585 rs2255655 chr3:12598839 C/G cg26432171 chr3:12704882 RAF1 -0.5 -6.5 -0.37 4e-10 Immature fraction of reticulocytes; CESC cis rs9926296 0.572 rs8047581 chr16:89884502 C/T cg27121462 chr16:89883253 FANCA 0.64 8.54 0.46 1.05e-15 Vitiligo; CESC cis rs1552244 0.748 rs9862221 chr3:10059658 G/T cg00149659 chr3:10157352 C3orf10 0.66 7.46 0.42 1.23e-12 Alzheimer's disease; CESC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg20811857 chr17:78079795 GAA -0.44 -6.31 -0.36 1.18e-9 Yeast infection; CESC cis rs2988277 0.713 rs10800313 chr1:167429985 C/T cg22356347 chr1:167427500 CD247 0.26 5.31 0.31 2.29e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs7918232 0.882 rs2149413 chr10:27430311 C/T cg14240646 chr10:27532245 ACBD5 0.67 6.36 0.36 8.93e-10 Breast cancer; CESC cis rs9287719 0.810 rs1990612 chr2:10781944 A/G cg02196655 chr2:10830764 NOL10 -0.37 -5.66 -0.33 3.86e-8 Prostate cancer; CESC cis rs11711311 1.000 rs2603789 chr3:113470479 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.58 7.68 0.43 3.1400000000000003e-13 IgG glycosylation; CESC cis rs7267979 0.934 rs2500399 chr20:25354694 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -15.92 -0.7 1.72e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg17143192 chr8:8559678 CLDN23 0.43 5.29 0.31 2.63e-7 Mood instability; CESC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.42 -5.6 -0.33 5.23e-8 Lymphocyte counts; CESC cis rs9788682 0.747 rs12910984 chr15:78891627 G/A cg24631222 chr15:78858424 CHRNA5 -0.83 -10.5 -0.54 8.35e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24877558 chr1:42801138 FOXJ3 0.59 6.47 0.37 4.76e-10 Gut microbiome composition (summer); CESC cis rs925228 0.504 rs7568176 chr2:24313758 T/A cg01493198 chr2:24299560 SF3B14 0.68 5.91 0.34 1.04e-8 Reticulocyte fraction of red cells;Reticulocyte count; CESC cis rs1670533 1.000 rs1670533 chr4:1078187 G/A cg04106633 chr4:1044584 NA 0.4 5.09 0.3 6.88e-7 Recombination rate (females); CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg12964741 chr18:77160221 NFATC1 0.41 6.02 0.35 5.79e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg21951975 chr1:209979733 IRF6 0.54 6.34 0.36 1.01e-9 Cleft lip with or without cleft palate; CESC cis rs9925964 0.967 rs1978487 chr16:31129942 C/T cg02466173 chr16:30829666 NA -0.32 -5.13 -0.3 5.71e-7 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6446731 0.517 rs2858087 chr4:3268892 A/T cg08886695 chr4:3369023 RGS12 0.35 5.28 0.31 2.74e-7 Mean platelet volume; CESC cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg23711669 chr6:146136114 FBXO30 0.97 14.97 0.68 4.06e-37 Lobe attachment (rater-scored or self-reported); CESC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.43 -0.32 1.29e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg17971929 chr21:40555470 PSMG1 0.97 12.95 0.62 4.63e-30 Cognitive function; CESC cis rs11723261 0.621 rs7692530 chr4:123445 G/C cg12746427 chr4:53362 ZNF718;ZNF595 0.48 6.5 0.37 3.9e-10 Immune response to smallpox vaccine (IL-6); CESC cis rs16854884 0.660 rs990320 chr3:143796305 T/C cg06585982 chr3:143692056 C3orf58 0.45 5.85 0.34 1.47e-8 Economic and political preferences (feminism/equality); CESC cis rs1003719 0.715 rs7282195 chr21:38508619 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -8.56 -0.47 9.46e-16 Eye color traits; CESC cis rs5769707 0.839 rs73176988 chr22:49989649 G/T cg20744362 chr22:50050164 C22orf34 0.41 6.89 0.39 4.09e-11 Monocyte count;Monocyte percentage of white cells; CESC cis rs12979813 1.000 rs8101802 chr19:11336182 G/C cg00586551 chr19:11347513 LOC55908;DOCK6 0.38 5.05 0.3 8.34e-7 HDL cholesterol; CESC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg13175981 chr1:150552382 MCL1 0.44 5.27 0.31 2.86e-7 Blood protein levels; CESC cis rs9457247 0.935 rs427824 chr6:167403918 T/G cg07741184 chr6:167504864 NA 0.28 5.08 0.3 7.24e-7 Crohn's disease; CESC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg17724175 chr1:150552817 MCL1 0.42 6.45 0.37 5.2400000000000005e-10 Melanoma; CESC cis rs6540556 0.954 rs7548219 chr1:209936466 A/G cg05527609 chr1:210001259 C1orf107 -0.46 -5.74 -0.33 2.65e-8 Red blood cell count; CESC cis rs78456975 0.550 rs10197874 chr2:1545310 A/G cg26248373 chr2:1572462 NA -0.57 -6.42 -0.37 6.13e-10 Placebo response in major depressive disorder (% change in symptom score); CESC trans rs9325144 0.647 rs17518186 chr12:38883665 T/C cg10679878 chr6:156759499 NA -0.33 -6.03 -0.35 5.46e-9 Morning vs. evening chronotype; CESC cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg23711669 chr6:146136114 FBXO30 1.0 15.5 0.69 5.39e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs72627123 0.867 rs11848920 chr14:74476866 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.73 5.63 0.33 4.49e-8 Morning vs. evening chronotype; CESC cis rs6087771 0.747 rs6058261 chr20:30235470 C/A cg13852791 chr20:30311386 BCL2L1 0.77 9.66 0.51 4.05e-19 Subcortical brain region volumes;Putamen volume; CESC cis rs11122272 0.735 rs2790878 chr1:231534390 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -6.6 -0.38 2.17e-10 Hemoglobin concentration; CESC cis rs2479106 0.591 rs10283413 chr9:126395188 A/T cg16191174 chr9:126692580 DENND1A 0.42 5.65 0.33 4.11e-8 Polycystic ovary syndrome; CESC cis rs4423214 0.547 rs11234030 chr11:71236967 G/A cg05163923 chr11:71159392 DHCR7 -0.54 -5.84 -0.34 1.55e-8 Vitamin D levels; CESC cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg22875332 chr1:76189707 ACADM 0.69 9.26 0.49 7.06e-18 Blood metabolite levels;Acylcarnitine levels; CESC cis rs4604732 0.578 rs7525209 chr1:247627404 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.44 5.44 0.32 1.21e-7 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CESC cis rs7592578 0.679 rs62181018 chr2:191323295 C/T cg10560079 chr2:191398806 TMEM194B -0.59 -5.74 -0.33 2.57e-8 Diastolic blood pressure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13205571 chr12:50135324 TMBIM6 -0.43 -6.02 -0.35 5.86e-9 Gambling; CESC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg22920501 chr2:26401640 FAM59B 0.91 10.38 0.54 2.08e-21 Gut microbiome composition (summer); CESC cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg11752832 chr7:134001865 SLC35B4 0.55 7.23 0.41 5.27e-12 Mean platelet volume; CESC cis rs9487051 1.000 rs6568571 chr6:109613252 A/T cg01475377 chr6:109611718 NA -0.39 -5.89 -0.34 1.19e-8 Reticulocyte fraction of red cells; CESC cis rs11166927 1.000 rs11778622 chr8:140805582 A/G cg16909799 chr8:140841666 TRAPPC9 0.61 9.0 0.48 4.52e-17 Pediatric non-alcoholic fatty liver disease activity score; CESC cis rs8017423 0.935 rs7144070 chr14:90753047 T/C cg14092571 chr14:90743983 NA -0.6 -9.06 -0.49 2.86e-17 Mortality in heart failure; CESC cis rs72781680 1.000 rs72781683 chr2:24247423 T/C cg08917208 chr2:24149416 ATAD2B 1.07 9.36 0.5 3.66e-18 Lymphocyte counts; CESC cis rs11098499 0.954 rs6849561 chr4:120409694 C/G cg24375607 chr4:120327624 NA -0.47 -5.82 -0.34 1.66e-8 Corneal astigmatism; CESC cis rs9527 0.590 rs3781282 chr10:104852419 C/T cg04362960 chr10:104952993 NT5C2 -0.43 -5.37 -0.31 1.72e-7 Arsenic metabolism; CESC cis rs2635047 0.811 rs9965170 chr18:44788274 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 5.36 0.31 1.85e-7 Educational attainment; CESC cis rs2832191 0.550 rs66484040 chr21:30511691 G/A cg24692254 chr21:30365293 RNF160 -0.61 -7.69 -0.43 2.86e-13 Dental caries; CESC cis rs2273669 0.667 rs11751295 chr6:109334458 C/G cg05315195 chr6:109294784 ARMC2 -0.67 -6.41 -0.37 6.73e-10 Prostate cancer; CESC cis rs7927592 0.871 rs12941 chr11:68382193 C/T cg20283391 chr11:68216788 NA -0.61 -7.37 -0.41 2.24e-12 Total body bone mineral density; CESC cis rs763121 0.853 rs4820345 chr22:39091151 T/C cg06544989 chr22:39130855 UNC84B 0.51 8.52 0.46 1.21e-15 Menopause (age at onset); CESC cis rs7191439 0.858 rs4238685 chr16:88775220 T/C cg02389323 chr16:88786976 FAM38A 1.08 8.84 0.48 1.36e-16 Plateletcrit; CESC cis rs4481887 1.000 rs7527822 chr1:248467301 A/G cg01631408 chr1:248437212 OR2T33 -0.35 -5.15 -0.3 5.08e-7 Common traits (Other); CESC cis rs2274273 0.870 rs4597235 chr14:55851987 A/G cg04306507 chr14:55594613 LGALS3 0.3 5.88 0.34 1.24e-8 Protein biomarker; CESC cis rs10744422 0.920 rs10773657 chr12:123327900 C/A cg25930673 chr12:123319894 HIP1R -0.72 -5.64 -0.33 4.46e-8 Schizophrenia; CESC cis rs9611565 0.512 rs4822052 chr22:42193741 G/A cg17376030 chr22:41985996 PMM1 0.71 7.52 0.42 8.45e-13 Vitiligo; CESC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg08392591 chr16:89556376 ANKRD11 0.6 8.1 0.45 2.08e-14 Multiple myeloma (IgH translocation); CESC cis rs155076 1.000 rs261430 chr13:21865242 C/T cg11317459 chr13:21872234 NA -1.08 -12.33 -0.6 6.43e-28 White matter hyperintensity burden; CESC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg05861140 chr6:150128134 PCMT1 -0.35 -5.11 -0.3 6.2e-7 Lung cancer; CESC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg00149659 chr3:10157352 C3orf10 0.77 9.66 0.51 4.22e-19 Alzheimer's disease; CESC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg05863683 chr7:1912471 MAD1L1 0.4 5.87 0.34 1.31e-8 Schizophrenia; CESC cis rs79349575 0.783 rs4793992 chr17:47008207 A/G cg16584676 chr17:46985605 UBE2Z 0.54 6.68 0.38 1.38e-10 Type 2 diabetes; CESC cis rs6493487 0.512 rs35496548 chr15:51139135 T/C cg02338191 chr15:51200825 AP4E1 0.6 5.89 0.34 1.18e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg27347728 chr4:17578864 LAP3 0.46 5.48 0.32 9.65e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6693567 0.565 rs696617 chr1:150376311 G/T cg09579323 chr1:150459698 TARS2 0.47 5.88 0.34 1.23e-8 Migraine; CESC cis rs933688 1.000 rs1035476 chr5:90745976 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.94 11.05 0.56 1.37e-23 Smoking behavior; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg07704502 chr1:153914740 DENND4B 0.39 6.33 0.36 1.06e-9 Fibrinogen levels; CESC cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg25427524 chr10:38739819 LOC399744 -0.67 -9.68 -0.51 3.49e-19 Extrinsic epigenetic age acceleration; CESC cis rs2455799 0.613 rs12491914 chr3:15808672 A/C cg16303742 chr3:15540471 COLQ -0.39 -6.13 -0.35 3.09e-9 Mean platelet volume; CESC cis rs7560272 0.538 rs3980695 chr2:73939552 A/G cg20560298 chr2:73613845 ALMS1 0.43 5.89 0.34 1.19e-8 Schizophrenia; CESC cis rs17023223 0.537 rs12085308 chr1:119677553 T/C cg05756136 chr1:119680316 WARS2 -0.46 -5.65 -0.33 4.24e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs854765 0.583 rs67253360 chr17:17828973 T/C cg09796270 chr17:17721594 SREBF1 0.43 6.05 0.35 4.93e-9 Total body bone mineral density; CESC trans rs875971 0.638 rs35986979 chr7:66088990 G/A cg26939375 chr7:64535504 NA -0.63 -8.47 -0.46 1.68e-15 Aortic root size; CESC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg00149659 chr3:10157352 C3orf10 0.73 8.54 0.46 1.05e-15 Alzheimer's disease; CESC cis rs977987 0.872 rs3743609 chr16:75467021 G/C cg03315344 chr16:75512273 CHST6 0.41 5.98 0.34 7.35e-9 Dupuytren's disease; CESC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg07677032 chr17:61819896 STRADA 0.45 5.92 0.34 1.01e-8 Prudent dietary pattern; CESC cis rs977987 0.806 rs7188604 chr16:75451170 T/G cg03315344 chr16:75512273 CHST6 0.41 5.84 0.34 1.56e-8 Dupuytren's disease; CESC cis rs4073582 0.595 rs708472 chr11:65930990 A/G cg14036092 chr11:66035641 RAB1B 0.54 7.53 0.42 7.89e-13 Gout; CESC cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg06027949 chr8:82754900 SNX16 -0.43 -5.22 -0.31 3.66e-7 Diastolic blood pressure; CESC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.19 -0.36 2.25e-9 Depression; CESC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg21770322 chr7:97807741 LMTK2 0.54 8.15 0.45 1.45e-14 Prostate cancer (SNP x SNP interaction); CESC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg12288994 chr5:1860383 NA 0.35 5.9 0.34 1.09e-8 Cardiovascular disease risk factors; CESC cis rs8114671 0.967 rs4911476 chr20:33780768 A/C cg06115741 chr20:33292138 TP53INP2 -0.42 -5.12 -0.3 6.02e-7 Height; CESC cis rs4237845 0.591 rs4760344 chr12:58320783 A/T cg00677455 chr12:58241039 CTDSP2 0.52 6.2 0.36 2.19e-9 Intelligence (multi-trait analysis); CESC cis rs524281 0.861 rs11227415 chr11:65885459 C/T cg14036092 chr11:66035641 RAB1B 0.55 5.66 0.33 3.94e-8 Electroencephalogram traits; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg04498971 chr17:56084468 SFRS1 0.51 6.7 0.38 1.27e-10 Gut microbiota (bacterial taxa); CESC cis rs3749237 0.595 rs4855861 chr3:49525962 G/T cg03060546 chr3:49711283 APEH 0.77 11.82 0.59 3.5e-26 Resting heart rate; CESC cis rs472402 0.560 rs2288447 chr5:6626091 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.5 -6.65 -0.38 1.65e-10 Response to amphetamines; CESC cis rs6693567 0.565 rs543179 chr1:150274610 G/A cg09579323 chr1:150459698 TARS2 -0.44 -5.83 -0.34 1.61e-8 Migraine; CESC cis rs6665290 0.904 rs1343743 chr1:227183125 C/T cg10327440 chr1:227177885 CDC42BPA -1.21 -33.33 -0.9 8.91e-97 Myeloid white cell count; CESC cis rs2072499 0.898 rs2736609 chr1:156202640 C/T cg24450063 chr1:156163899 SLC25A44 0.8 11.95 0.59 1.24e-26 Testicular germ cell tumor; CESC cis rs10927875 0.619 rs28537253 chr1:16148600 A/C cg21385522 chr1:16154831 NA -0.69 -9.72 -0.51 2.65e-19 Dilated cardiomyopathy; CESC cis rs561341 0.941 rs550213 chr17:30317518 C/G cg00745463 chr17:30367425 LRRC37B -0.67 -6.82 -0.39 6.17e-11 Hip circumference adjusted for BMI; CESC cis rs7605827 0.930 rs4668911 chr2:15610650 A/C cg19274914 chr2:15703543 NA 0.35 6.13 0.35 3.19e-9 Educational attainment (years of education); CESC cis rs6540559 0.611 rs76766079 chr1:209997731 C/T cg23283495 chr1:209979779 IRF6 0.49 5.35 0.31 1.89e-7 Cleft lip with or without cleft palate; CESC cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg03676636 chr4:99064102 C4orf37 0.33 5.04 0.3 8.47e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10198628 0.623 rs779339 chr2:13043884 A/G cg13921956 chr2:12858555 TRIB2 -0.4 -5.39 -0.31 1.53e-7 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2228479 0.850 rs62052660 chr16:89847420 T/A cg04013166 chr16:89971882 TCF25 0.77 6.65 0.38 1.65e-10 Skin colour saturation; CESC cis rs761746 0.960 rs5753667 chr22:31905703 G/A cg25791279 chr22:32026902 PISD -0.49 -5.52 -0.32 7.93e-8 Intelligence; CESC cis rs10242455 0.702 rs45451992 chr7:99041416 C/A cg25640893 chr7:99214727 ZNF498 1.26 7.12 0.4 1.02e-11 Blood metabolite levels; CESC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.4 5.29 0.31 2.6e-7 Lymphocyte counts; CESC cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg23711669 chr6:146136114 FBXO30 1.02 15.62 0.69 2.01e-39 Lobe attachment (rater-scored or self-reported); CESC cis rs7914558 1.000 rs7911789 chr10:104756374 T/C cg04362960 chr10:104952993 NT5C2 0.45 6.09 0.35 4.01e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg12311346 chr5:56204834 C5orf35 -0.45 -5.49 -0.32 9.29e-8 Coronary artery disease; CESC cis rs9287719 0.967 rs6759740 chr2:10747271 A/G cg00105475 chr2:10696890 NA 0.38 5.57 0.32 6.34e-8 Prostate cancer; CESC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg17949981 chr6:28129498 ZNF389 0.42 5.23 0.31 3.39e-7 Depression; CESC cis rs690037 0.673 rs690573 chr3:16376440 G/T cg23474789 chr3:16306055 DPH3;OXNAD1 -0.49 -6.64 -0.38 1.75e-10 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg05052335 chr5:130970657 RAPGEF6 0.46 6.01 0.35 6.11e-9 Gut microbiota (bacterial taxa); CESC trans rs875971 0.508 rs6947808 chr7:66045082 A/G cg26939375 chr7:64535504 NA -0.53 -7.31 -0.41 3.22e-12 Aortic root size; CESC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg22535103 chr8:58192502 C8orf71 -0.89 -8.76 -0.47 2.45e-16 Developmental language disorder (linguistic errors); CESC cis rs6500395 0.925 rs16946342 chr16:48668542 G/A cg04672837 chr16:48644449 N4BP1 0.52 6.52 0.37 3.6e-10 Response to tocilizumab in rheumatoid arthritis; CESC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg00802000 chr16:706648 WDR90 -0.41 -6.21 -0.36 2.02e-9 Height; CESC cis rs10979 1.000 rs9484767 chr6:143887912 C/A cg25407410 chr6:143891975 LOC285740 -0.61 -9.2 -0.49 1.11e-17 Hypospadias; CESC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg12718519 chr1:2058417 PRKCZ -0.26 -5.56 -0.32 6.72e-8 Height; CESC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg04414720 chr1:150670196 GOLPH3L 0.56 7.36 0.41 2.26e-12 Melanoma; CESC cis rs2880765 0.835 rs4842886 chr15:86035773 G/A cg19183879 chr15:85880815 NA -0.25 -5.3 -0.31 2.49e-7 Coronary artery disease; CESC cis rs2519796 0.531 rs2263807 chr9:136807021 A/C cg13751417 chr9:136814406 VAV2 -0.43 -5.74 -0.33 2.59e-8 Hematocrit;Hemoglobin concentration; CESC cis rs10896135 0.526 rs624561 chr11:66414915 C/T cg15964523 chr11:66469143 SPTBN2 0.41 5.34 0.31 2.02e-7 Bipolar disorder; CESC trans rs9929218 0.906 rs34565494 chr16:68741769 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -9.6 -0.51 6.39e-19 Colorectal cancer; CESC cis rs10883723 0.773 rs2296578 chr10:104240974 C/G cg22532475 chr10:104410764 TRIM8 -0.32 -5.43 -0.32 1.27e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs3857067 1.000 rs1588384 chr4:95001354 T/G cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.6 -0.42 5.29e-13 QT interval; CESC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg08859206 chr1:53392774 SCP2 -0.62 -8.27 -0.45 6.63e-15 Monocyte count; CESC cis rs2760061 0.819 rs1745416 chr1:228204497 G/A cg18477163 chr1:228402036 OBSCN 0.33 5.75 0.33 2.4e-8 Diastolic blood pressure; CESC cis rs6580649 0.825 rs4760611 chr12:48421449 A/G cg24011408 chr12:48396354 COL2A1 0.4 5.18 0.3 4.39e-7 Lung cancer; CESC cis rs2204008 0.743 rs11495614 chr12:38156358 C/T cg26384229 chr12:38710491 ALG10B 0.72 9.78 0.52 1.71e-19 Bladder cancer; CESC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg12463550 chr7:65579703 CRCP 0.57 7.17 0.4 7.53e-12 Aortic root size; CESC cis rs6570726 0.935 rs430561 chr6:145813140 C/T cg23711669 chr6:146136114 FBXO30 0.81 12.75 0.62 2.41e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs2180341 0.960 rs7756884 chr6:127684018 A/G cg27446573 chr6:127587934 RNF146 1.06 15.51 0.69 4.62e-39 Breast cancer; CESC cis rs35306767 0.953 rs35174953 chr10:961191 C/A cg20503657 chr10:835505 NA 0.75 8.33 0.46 4.53e-15 Eosinophil percentage of granulocytes; CESC cis rs6121246 0.529 rs6120862 chr20:30199459 T/C cg13852791 chr20:30311386 BCL2L1 0.55 5.13 0.3 5.66e-7 Mean corpuscular hemoglobin; CESC cis rs9595066 0.627 rs9562536 chr13:44731588 G/A cg04068111 chr13:44716778 NA -0.44 -6.01 -0.35 6.17e-9 Schizophrenia; CESC cis rs6456156 0.565 rs6456153 chr6:167472167 T/C cg23791538 chr6:167370224 RNASET2 -0.5 -6.44 -0.37 5.46e-10 Primary biliary cholangitis; CESC cis rs1185460 0.967 rs4545564 chr11:118937518 T/C cg01677386 chr11:118938358 VPS11 -0.44 -5.64 -0.33 4.35e-8 Coronary artery disease; CESC cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg03433033 chr1:76189801 ACADM 0.7 8.56 0.47 9.39e-16 Blood metabolite levels;Acylcarnitine levels; CESC cis rs5758659 0.845 rs5758645 chr22:42598951 T/G cg05082376 chr22:42548792 NA -0.37 -5.41 -0.32 1.4e-7 Cognitive function; CESC cis rs7520050 0.966 rs6677007 chr1:46400590 A/G cg24296786 chr1:45957014 TESK2 0.44 5.49 0.32 9.64e-8 Red blood cell count;Reticulocyte count; CESC cis rs3820068 0.705 rs4646022 chr1:15839112 G/A cg18192808 chr1:15853278 DNAJC16 0.46 5.7 0.33 3.23e-8 Systolic blood pressure; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26085966 chr14:64319812 SYNE2 -0.49 -6.24 -0.36 1.69e-9 Fibrinogen levels; CESC cis rs6570726 0.967 rs373527 chr6:145801861 C/T cg05347473 chr6:146136440 FBXO30 0.42 5.76 0.33 2.38e-8 Lobe attachment (rater-scored or self-reported); CESC cis rs7481584 0.624 rs369461 chr11:3061992 A/G cg25174290 chr11:3078921 CARS -0.54 -7.58 -0.42 5.79e-13 Calcium levels; CESC cis rs12586317 0.547 rs112138868 chr14:35444385 C/T cg16230307 chr14:35515116 FAM177A1 0.96 10.66 0.55 2.55e-22 Psoriasis; CESC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg01416388 chr22:39784598 NA -0.57 -6.9 -0.39 3.89e-11 Intelligence (multi-trait analysis); CESC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.51 -0.32 8.45e-8 Huntington's disease progression; CESC cis rs7580658 0.676 rs4662717 chr2:128013504 C/T cg10021288 chr2:128175891 PROC -0.33 -5.35 -0.31 1.9e-7 Protein C levels; CESC cis rs12500824 0.564 rs62300856 chr4:77282063 C/T cg20311846 chr4:77356250 SHROOM3 0.37 6.88 0.39 4.32e-11 Coronary artery disease; CESC cis rs9346455 0.614 rs9364151 chr6:71997071 T/C cg27238071 chr6:71998145 OGFRL1 0.6 5.93 0.34 9.65e-9 Antipsychotic drug-induced weight gain (time interaction);Antipsychotic drug-induced weight gain; CESC cis rs62458065 0.713 rs28421905 chr7:32489501 G/A cg20159608 chr7:32802032 NA -0.53 -5.08 -0.3 7.29e-7 Metabolite levels (HVA/MHPG ratio); CESC cis rs2243480 1.000 rs316329 chr7:65608416 A/C cg12463550 chr7:65579703 CRCP 0.76 5.82 0.34 1.69e-8 Diabetic kidney disease; CESC cis rs11098499 0.954 rs6822679 chr4:120402702 A/C cg09307838 chr4:120376055 NA 0.93 13.0 0.62 3.14e-30 Corneal astigmatism; CESC cis rs6500395 0.962 rs9922356 chr16:48640025 C/T cg04672837 chr16:48644449 N4BP1 0.47 5.57 0.32 6.4e-8 Response to tocilizumab in rheumatoid arthritis; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15330255 chr10:103454985 FBXW4 -0.45 -6.1 -0.35 3.75e-9 Asthma; CESC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg06808227 chr14:105710500 BRF1 -0.52 -5.69 -0.33 3.44e-8 Mean platelet volume;Platelet distribution width; CESC cis rs7927771 0.524 rs4752860 chr11:47705015 C/A cg18512352 chr11:47633146 NA -0.36 -5.65 -0.33 4.17e-8 Subjective well-being; CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg18765753 chr7:1198926 ZFAND2A -0.5 -7.45 -0.42 1.33e-12 Longevity;Endometriosis; CESC cis rs910316 0.737 rs175510 chr14:75524839 G/A cg11812906 chr14:75593930 NEK9 -0.84 -13.7 -0.64 1.13e-32 Height; CESC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg17949981 chr6:28129498 ZNF389 0.42 5.38 0.31 1.6e-7 Depression; CESC cis rs10871290 0.507 rs3851731 chr16:74485788 C/T cg01733217 chr16:74700730 RFWD3 0.62 7.66 0.43 3.52e-13 Breast cancer; CESC cis rs8067545 0.611 rs9898080 chr17:20035257 A/G cg13482628 chr17:19912719 NA 0.4 5.21 0.3 3.75e-7 Schizophrenia; CESC cis rs34779708 0.931 rs11010130 chr10:35513307 T/C cg03585969 chr10:35415529 CREM 0.75 9.3 0.5 5.36e-18 Inflammatory bowel disease;Crohn's disease; CESC cis rs524281 0.861 rs3825067 chr11:65878419 A/G cg14036092 chr11:66035641 RAB1B 0.6 6.27 0.36 1.47e-9 Electroencephalogram traits; CESC cis rs2880765 0.835 rs4843063 chr15:86048748 G/T cg10818794 chr15:86012489 AKAP13 -0.34 -5.22 -0.31 3.68e-7 Coronary artery disease; CESC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg24562669 chr7:97807699 LMTK2 0.47 6.73 0.38 1.07e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs1511802 0.501 rs7661323 chr4:187115996 T/G cg24794857 chr4:187113578 CYP4V2 0.41 5.14 0.3 5.31e-7 Blood protein levels; CESC cis rs473651 0.935 rs559579 chr2:239339501 G/C cg21699342 chr2:239360505 ASB1 0.41 5.72 0.33 2.92e-8 Multiple system atrophy; CESC cis rs67460515 0.563 rs13071892 chr3:160817877 A/C cg03342759 chr3:160939853 NMD3 -0.51 -6.44 -0.37 5.65e-10 Parkinson's disease; CESC cis rs11785693 0.862 rs73183633 chr8:4994543 G/A cg26367366 chr8:4980734 NA 0.84 8.09 0.45 2.16e-14 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs17253792 0.822 rs78261053 chr14:56061784 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.84 5.62 0.33 4.81e-8 Putamen volume; CESC cis rs941207 0.507 rs1107479 chr12:57030686 C/T cg05584118 chr12:57595605 LRP1 0.38 5.35 0.31 1.92e-7 Platelet count; CESC cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11722228 0.508 rs3756227 chr4:10087995 C/A cg26043149 chr18:55253948 FECH 0.88 10.88 0.56 4.95e-23 Gout;Urate levels;Serum uric acid levels; CESC cis rs12986413 0.624 rs2108825 chr19:2136515 T/C cg09261902 chr19:2140048 AP3D1 0.35 5.53 0.32 7.79e-8 Height; CESC cis rs6736093 0.966 rs11676040 chr2:112713115 T/C cg12686935 chr2:112915763 FBLN7 -0.42 -5.46 -0.32 1.1e-7 Coronary artery disease; CESC cis rs4423214 0.840 rs1790341 chr11:71177578 T/C cg05163923 chr11:71159392 DHCR7 -0.65 -7.55 -0.42 6.91e-13 Vitamin D levels; CESC cis rs1707322 0.721 rs10789471 chr1:46215619 G/A cg03146154 chr1:46216737 IPP 0.82 11.53 0.58 3.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs74181299 0.964 rs2723065 chr2:65279414 A/G cg05010058 chr2:65284262 CEP68 0.33 5.79 0.34 1.98e-8 Pulse pressure; CESC cis rs3747547 0.818 rs7027227 chr9:37929809 C/G cg13774184 chr9:37916125 SHB 0.48 5.21 0.3 3.84e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs11098499 0.604 rs17051352 chr4:120581427 G/A cg25214090 chr10:38739885 LOC399744 0.61 8.03 0.44 3.12e-14 Corneal astigmatism; CESC cis rs7582720 1.000 rs7605484 chr2:203724495 T/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.85 7.32 0.41 3.04e-12 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CESC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg02569458 chr12:86230093 RASSF9 -0.46 -7.15 -0.4 8.28e-12 Major depressive disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06166242 chr6:148663498 SASH1 -0.59 -7.33 -0.41 2.85e-12 Gut microbiome composition (summer); CESC cis rs4664304 0.658 rs2667015 chr2:160868586 T/C cg03641300 chr2:160917029 PLA2R1 -0.46 -6.53 -0.37 3.38e-10 Crohn's disease;Inflammatory bowel disease; CESC cis rs9902453 0.904 rs8071742 chr17:28361669 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.84 -0.43 1.11e-13 Coffee consumption (cups per day); CESC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.5 0.54 8.84e-22 Prudent dietary pattern; CESC cis rs11098499 0.863 rs17050695 chr4:120489527 G/T cg09307838 chr4:120376055 NA 0.88 11.81 0.59 3.78e-26 Corneal astigmatism; CESC cis rs61931739 0.500 rs11053066 chr12:34185318 G/A cg19457237 chr12:34500585 NA -0.39 -5.39 -0.31 1.53e-7 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09983252 chr4:119555556 NA -0.59 -7.48 -0.42 1.1e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19009323 chr9:132935030 FREQ -0.57 -6.03 -0.35 5.41e-9 Gut microbiome composition (summer); CESC cis rs3020736 0.500 rs6002616 chr22:42504679 A/G cg15557168 chr22:42548783 NA 0.45 6.3 0.36 1.25e-9 Autism spectrum disorder or schizophrenia; CESC cis rs9660992 0.710 rs1180721 chr1:205232696 T/C cg21643547 chr1:205240462 TMCC2 -0.49 -6.84 -0.39 5.31e-11 Mean corpuscular volume;Mean platelet volume; CESC cis rs9457247 0.602 rs17615336 chr6:167506734 A/G cg23791538 chr6:167370224 RNASET2 -0.54 -6.79 -0.38 7.52e-11 Crohn's disease; CESC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg00750074 chr16:89608354 SPG7 -0.41 -5.75 -0.33 2.44e-8 Multiple myeloma (IgH translocation); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15141371 chr3:39195098 CSRNP1 0.5 6.02 0.35 5.7e-9 Gut microbiome composition (summer); CESC cis rs644799 0.610 rs1255179 chr11:95472097 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.49 6.91 0.39 3.66e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs727505 0.866 rs56216989 chr7:124729068 T/A cg23710748 chr7:124431027 NA -0.4 -6.52 -0.37 3.56e-10 Lewy body disease; CESC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg08859206 chr1:53392774 SCP2 0.72 11.25 0.57 2.95e-24 Monocyte count; CESC cis rs807669 0.934 rs762523 chr22:19180589 A/G cg02655711 chr22:19163373 SLC25A1 0.97 15.0 0.68 2.98e-37 Metabolite levels; CESC cis rs10876993 0.928 rs10877008 chr12:58103592 A/G cg18357645 chr12:58087776 OS9 0.64 10.52 0.54 7.31e-22 Celiac disease or Rheumatoid arthritis; CESC trans rs2415984 0.846 rs35563644 chr14:46850583 A/G cg14945696 chr3:52713679 PBRM1 -0.4 -6.02 -0.35 5.85e-9 Number of children ever born; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20947082 chr1:233749643 KCNK1 0.52 6.11 0.35 3.54e-9 Gut microbiome composition (summer); CESC cis rs9300255 0.620 rs1727311 chr12:123660716 T/G cg00376283 chr12:123451042 ABCB9 0.61 6.2 0.36 2.2e-9 Neutrophil percentage of white cells; CESC trans rs17685 0.712 rs7785025 chr7:75628101 C/T cg19862616 chr7:65841803 NCRNA00174 -0.82 -11.82 -0.59 3.56e-26 Coffee consumption;Coffee consumption (cups per day); CESC cis rs9902453 1.000 rs4533340 chr17:28277951 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 8.28 0.45 6.2e-15 Coffee consumption (cups per day); CESC cis rs965469 0.817 rs16988490 chr20:3335431 C/T cg17110299 chr20:3385021 C20orf194 -0.41 -5.3 -0.31 2.42e-7 IFN-related cytopenia; CESC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg00277769 chr7:97922759 BAIAP2L1 0.32 5.2 0.3 4.05e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs7208859 0.573 rs73267873 chr17:29068457 C/T cg19761014 chr17:28927070 LRRC37B2 0.72 6.21 0.36 2.07e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs77106637 0.860 rs11603334 chr11:72432985 G/A cg03713592 chr11:72463424 ARAP1 1.22 11.1 0.56 9.43e-24 Type 2 diabetes; CESC cis rs2637266 0.967 rs12246436 chr10:78352914 C/T cg18941641 chr10:78392320 NA 0.41 7.55 0.42 7.02e-13 Pulmonary function; CESC cis rs4642101 0.737 rs4447735 chr3:12825513 C/T cg24848339 chr3:12840334 CAND2 0.38 5.92 0.34 1.01e-8 QRS complex (12-leadsum); CESC cis rs829883 0.724 rs11109508 chr12:98905985 T/C cg25150519 chr12:98850993 NA -0.64 -7.91 -0.44 7.1e-14 Colorectal adenoma (advanced); CESC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg01988459 chr11:68622903 NA -0.38 -5.19 -0.3 4.26e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs1953600 0.754 rs2573348 chr10:81925785 C/T cg00277334 chr10:82204260 NA -0.42 -5.89 -0.34 1.16e-8 Sarcoidosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20543431 chr6:34857162 ANKS1A;TAF11 0.55 6.0 0.35 6.3e-9 Gut microbiome composition (summer); CESC trans rs2018683 1.000 rs4719962 chr7:28999237 G/A cg19402173 chr7:128379420 CALU -0.65 -8.51 -0.46 1.33e-15 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CESC cis rs10883723 0.810 rs7074343 chr10:104283165 G/A cg22532475 chr10:104410764 TRIM8 -0.33 -5.67 -0.33 3.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs7129220 0.512 rs1867137 chr11:10228809 G/A cg01453529 chr11:10209919 SBF2 -0.45 -5.55 -0.32 6.79e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs9303280 0.934 rs56380902 chr17:38066372 T/C cg20243544 chr17:37824526 PNMT 0.51 6.96 0.39 2.67e-11 Self-reported allergy; CESC cis rs6540559 0.673 rs114467813 chr1:210017785 G/A cg23283495 chr1:209979779 IRF6 0.5 5.32 0.31 2.16e-7 Cleft lip with or without cleft palate; CESC trans rs2688325 0.699 rs13251994 chr8:3757722 G/C cg00283030 chr2:132056444 LOC440910 -0.31 -6.24 -0.36 1.72e-9 Menarche (age at onset); CESC cis rs684232 0.666 rs838372 chr17:566428 C/T cg12384639 chr17:618140 VPS53 0.4 5.2 0.3 3.92e-7 Prostate cancer; CESC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg17971929 chr21:40555470 PSMG1 -0.6 -7.87 -0.44 9.13e-14 Menarche (age at onset); CESC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg22823121 chr1:150693482 HORMAD1 -0.45 -6.36 -0.36 9e-10 Melanoma; CESC trans rs629535 0.814 rs72654071 chr8:70079484 A/G cg21567404 chr3:27674614 NA -0.89 -10.53 -0.54 6.98e-22 Dupuytren's disease; CESC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg08027265 chr7:2291960 NA -0.35 -5.26 -0.31 2.91e-7 Bipolar disorder and schizophrenia; CESC cis rs9914544 0.689 rs8073236 chr17:18787182 C/G cg26378065 chr17:18585709 ZNF286B 0.45 5.99 0.35 6.73e-9 Educational attainment (years of education); CESC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg17971929 chr21:40555470 PSMG1 1.05 16.19 0.71 1.86e-41 Cognitive function; CESC cis rs637571 0.615 rs10160792 chr11:65667149 C/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.42 5.19 0.3 4.18e-7 Eosinophil percentage of white cells; CESC cis rs4919694 1.000 rs17787717 chr10:104695699 T/G cg04362960 chr10:104952993 NT5C2 0.76 5.99 0.35 6.7e-9 Arsenic metabolism; CESC cis rs2479106 0.656 rs7857196 chr9:126465958 A/G cg16191174 chr9:126692580 DENND1A -0.42 -5.1 -0.3 6.37e-7 Polycystic ovary syndrome; CESC cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.73 -9.12 -0.49 1.93e-17 Multiple sclerosis; CESC cis rs2228479 0.867 rs34604714 chr16:89948985 A/G cg00800038 chr16:89945340 TCF25 -0.88 -7.85 -0.43 1.01e-13 Skin colour saturation; CESC cis rs2072732 0.756 rs55949537 chr1:2936746 A/T cg03976712 chr1:2946727 NA 0.33 5.15 0.3 5.01e-7 Plateletcrit; CESC cis rs3806843 1.000 rs3733707 chr5:140181892 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.16 -0.3 4.96e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1801251 0.727 rs283482 chr2:233646920 A/T cg25237894 chr2:233734115 C2orf82 0.36 6.18 0.35 2.46e-9 Coronary artery disease; CESC cis rs858239 0.600 rs6956595 chr7:23134256 A/G cg23682824 chr7:23144976 KLHL7 0.54 7.34 0.41 2.63e-12 Cerebrospinal fluid biomarker levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23819836 chr6:15663134 DTNBP1 0.6 7.32 0.41 2.88e-12 Gut microbiome composition (summer); CESC cis rs7243790 0.805 rs12604412 chr18:51899292 A/G cg04730925 chr18:51795821 POLI -0.42 -5.56 -0.32 6.66e-8 Diastolic blood pressure; CESC cis rs9611565 0.877 rs3817999 chr22:41747717 A/G cg03806693 chr22:41940476 POLR3H 0.8 10.05 0.53 2.49e-20 Vitiligo; CESC trans rs12310956 0.532 rs1906134 chr12:33957135 A/C cg26384229 chr12:38710491 ALG10B 0.59 8.35 0.46 3.79e-15 Morning vs. evening chronotype; CESC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg08968635 chr6:28129556 ZNF389 0.4 5.22 0.31 3.69e-7 Parkinson's disease; CESC cis rs713587 0.521 rs6545766 chr2:25077856 C/T cg01884057 chr2:25150051 NA 0.35 6.61 0.38 2.09e-10 Body mass index in non-asthmatics; CESC cis rs2153904 0.793 rs1772145 chr1:205695695 C/T cg23034840 chr1:205782522 SLC41A1 0.54 5.91 0.34 1.06e-8 Prostate-specific antigen levels; CESC cis rs8062405 0.755 rs55792032 chr16:28599411 A/G cg07382826 chr16:28625726 SULT1A1 0.4 6.72 0.38 1.11e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs6938 0.618 rs2044157 chr15:75225808 G/C cg17294928 chr15:75287854 SCAMP5 0.51 6.65 0.38 1.66e-10 Breast cancer; CESC cis rs7267979 1.000 rs2474777 chr20:25272633 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.8 15.92 0.7 1.64e-40 Liver enzyme levels (alkaline phosphatase); CESC cis rs9910055 0.593 rs58392387 chr17:42297889 A/G cg13607699 chr17:42295918 UBTF 0.86 12.51 0.61 1.53e-28 Total body bone mineral density; CESC cis rs7100689 0.753 rs1856773 chr10:82060484 T/A cg09936400 chr10:82049201 MAT1A 0.37 5.3 0.31 2.41e-7 Post bronchodilator FEV1; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17371487 chr19:9789027 NA 0.37 6.41 0.37 6.61e-10 Gambling; CESC cis rs6598955 0.543 rs112752634 chr1:26534217 G/A cg04990556 chr1:26633338 UBXN11 0.81 9.12 0.49 1.92e-17 Obesity-related traits; CESC cis rs2996428 0.628 rs6667526 chr1:3774603 G/A cg22529645 chr1:3704559 LRRC47 0.4 5.06 0.3 7.7e-7 Red cell distribution width; CESC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg17372223 chr3:52568218 NT5DC2 0.44 6.49 0.37 4.23e-10 Bipolar disorder; CESC cis rs17253792 0.822 rs28478195 chr14:56047851 G/A cg01858014 chr14:56050164 KTN1 -0.96 -7.65 -0.43 3.84e-13 Putamen volume; CESC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg08968635 chr6:28129556 ZNF389 -0.42 -5.62 -0.33 4.9e-8 Depression; CESC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.57 -6.82 -0.39 6.12e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1003719 0.788 rs8133549 chr21:38447489 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.62 8.71 0.47 3.4e-16 Eye color traits; CESC cis rs5769765 0.773 rs6520065 chr22:50294470 A/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.45 -5.21 -0.3 3.79e-7 Schizophrenia; CESC cis rs4722166 0.695 rs7793125 chr7:22809160 A/G cg13104385 chr7:22767384 IL6 0.38 5.62 0.33 4.78e-8 Lung cancer; CESC cis rs6693567 0.507 rs863862 chr1:150352361 T/A cg09579323 chr1:150459698 TARS2 0.48 6.12 0.35 3.27e-9 Migraine; CESC cis rs9815354 0.812 rs73073355 chr3:41842332 G/A cg03022575 chr3:42003672 ULK4 0.7 6.04 0.35 5.26e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg20891283 chr12:69753455 YEATS4 0.9 14.98 0.68 3.63e-37 Blood protein levels; CESC cis rs16854884 0.657 rs6791078 chr3:143736876 A/G cg06585982 chr3:143692056 C3orf58 0.5 6.7 0.38 1.26e-10 Economic and political preferences (feminism/equality); CESC cis rs11901793 0.505 rs34446892 chr2:237495452 C/T cg25295825 chr2:237489920 CXCR7 0.66 5.86 0.34 1.38e-8 Total mean fractional anisotropy measurement in first episode schizophrenia; CESC cis rs2425143 1.000 rs6058303 chr20:34290281 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 5.54 0.32 7.37e-8 Blood protein levels; CESC cis rs5769707 0.632 rs135871 chr22:50008969 A/G cg20744362 chr22:50050164 C22orf34 0.37 5.24 0.31 3.23e-7 Monocyte count;Monocyte percentage of white cells; CESC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg02569458 chr12:86230093 RASSF9 0.51 7.7 0.43 2.65e-13 Major depressive disorder; CESC cis rs7580658 0.864 rs1566823 chr2:128018192 A/G cg10021288 chr2:128175891 PROC -0.38 -6.1 -0.35 3.64e-9 Protein C levels; CESC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 5.63 0.33 4.52e-8 Personality dimensions; CESC cis rs9837602 1.000 rs6790877 chr3:99779658 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.5 7.11 0.4 1.1e-11 Breast cancer; CESC cis rs2066819 1.000 rs2695788 chr12:56697110 G/A cg26316697 chr12:56727976 PAN2 -0.69 -6.64 -0.38 1.74e-10 Psoriasis vulgaris; CESC cis rs7247513 0.930 rs34321000 chr19:12713088 C/T cg11738485 chr19:12877000 HOOK2 0.42 5.16 0.3 4.77e-7 Bipolar disorder; CESC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg24250549 chr1:154909240 PMVK 0.72 10.85 0.55 6.34e-23 Prostate cancer; CESC cis rs6964587 0.935 rs9770444 chr7:91783162 T/G cg17063962 chr7:91808500 NA 0.59 8.24 0.45 8.03e-15 Breast cancer; CESC cis rs6973256 0.637 rs1362739 chr7:133430934 C/A cg10665199 chr7:133106180 EXOC4 0.43 6.0 0.35 6.45e-9 Intelligence (multi-trait analysis); CESC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg17949981 chr6:28129498 ZNF389 -0.43 -5.66 -0.33 4.02e-8 Depression; CESC trans rs7618501 0.602 rs34831713 chr3:50118748 T/C cg21659725 chr3:3221576 CRBN -0.5 -7.0 -0.4 2.12e-11 Intelligence (multi-trait analysis); CESC trans rs2963826 0.589 rs298091 chr5:58996603 A/T cg03705947 chr1:68152081 GADD45A 0.5 6.81 0.39 6.38e-11 Obesity-related traits; CESC cis rs6912958 0.967 rs6914299 chr6:88149176 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -5.51 -0.32 8.64e-8 Monocyte percentage of white cells; CESC trans rs975752 0.850 rs10883450 chr10:101923421 C/T cg16450097 chr8:101348467 NA -0.47 -6.18 -0.35 2.38e-9 Schizophrenia; CESC cis rs67460515 0.563 rs11720263 chr3:160848293 T/C cg03342759 chr3:160939853 NMD3 -0.53 -6.82 -0.39 6.24e-11 Parkinson's disease; CESC cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg00033643 chr7:134001901 SLC35B4 0.43 5.52 0.32 7.93e-8 Mean platelet volume; CESC cis rs2302190 0.882 rs8068135 chr17:56654210 A/C cg25885038 chr17:56607967 SEPT4 -0.4 -5.43 -0.32 1.27e-7 Vitamin D levels; CESC cis rs2204008 0.774 rs11514062 chr12:38332297 A/C cg26384229 chr12:38710491 ALG10B 0.65 9.65 0.51 4.47e-19 Bladder cancer; CESC cis rs10870270 1.000 rs10781564 chr10:133757922 A/G cg08754478 chr10:133766260 PPP2R2D -0.58 -7.58 -0.42 5.74e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CESC cis rs11098499 0.821 rs3775852 chr4:120454556 A/G cg09307838 chr4:120376055 NA 0.91 12.54 0.61 1.24e-28 Corneal astigmatism; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24596729 chr1:165345813 NA -0.49 -6.67 -0.38 1.48e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs1707322 0.721 rs61784796 chr1:46163256 A/G cg05343316 chr1:45956843 TESK2 0.51 6.2 0.36 2.19e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs4849845 0.598 rs4848586 chr2:121061291 C/T cg24070213 chr2:121070622 NA 0.42 6.08 0.35 4.29e-9 Mean platelet volume; CESC cis rs5758659 0.714 rs5751220 chr22:42516205 A/C cg05082376 chr22:42548792 NA 0.35 5.11 0.3 6.08e-7 Cognitive function; CESC cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg06766960 chr11:133703094 NA -0.38 -5.38 -0.31 1.61e-7 Childhood ear infection; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg15533809 chr19:2076775 MOBKL2A 0.44 6.09 0.35 4.04e-9 Fibrinogen levels; CESC cis rs9584850 0.574 rs60492361 chr13:99172653 T/C cg20750642 chr13:99100586 FARP1 -0.36 -5.18 -0.3 4.32e-7 Neuroticism; CESC cis rs7647973 1.000 rs12583 chr3:49571462 G/T cg06212747 chr3:49208901 KLHDC8B -0.6 -7.74 -0.43 2.09e-13 Menarche (age at onset); CESC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.03 0.49 3.64e-17 Tonsillectomy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27665823 chr16:460516 DECR2 -0.63 -7.1 -0.4 1.16e-11 Gut microbiome composition (summer); CESC cis rs2404602 0.536 rs17364330 chr15:76765385 A/T cg26408565 chr15:76604113 ETFA -0.43 -6.41 -0.37 6.6e-10 Blood metabolite levels; CESC cis rs933688 1.000 rs10059163 chr5:90742444 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.15 15.71 0.69 9.34e-40 Smoking behavior; CESC cis rs7267979 1.000 rs4815408 chr20:25346678 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.44 -0.32 1.21e-7 Liver enzyme levels (alkaline phosphatase); CESC cis rs2933343 0.859 rs789245 chr3:128583580 C/A cg25356066 chr3:128598488 ACAD9 0.55 6.75 0.38 9.52e-11 IgG glycosylation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05402854 chr6:111408840 SLC16A10 0.53 6.54 0.37 3.15e-10 Gut microbiome composition (summer); CESC cis rs734999 0.566 rs4648658 chr1:2560882 G/A cg20673091 chr1:2541236 MMEL1 -0.47 -8.15 -0.45 1.49e-14 Ulcerative colitis; CESC cis rs2569991 0.636 rs361221 chr3:12922767 A/C cg22481960 chr3:13008800 IQSEC1 0.54 6.59 0.38 2.43e-10 Periodontitis (DPAL); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20269352 chr1:44483206 SLC6A9 -0.38 -6.52 -0.37 3.52e-10 Gambling; CESC cis rs7772486 0.875 rs2777484 chr6:146334162 A/G cg23711669 chr6:146136114 FBXO30 0.81 11.71 0.58 8.24e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.29 -0.36 1.34e-9 Developmental language disorder (linguistic errors); CESC cis rs60154123 0.730 rs652241 chr1:210465029 A/T cg25204440 chr1:209979598 IRF6 0.45 5.05 0.3 8.23e-7 Coronary artery disease; CESC cis rs962856 0.756 rs13016812 chr2:67624302 C/T cg09028215 chr2:67624308 ETAA1 0.43 5.38 0.31 1.67e-7 Pancreatic cancer; CESC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg22823121 chr1:150693482 HORMAD1 0.47 6.86 0.39 4.77e-11 Melanoma; CESC cis rs3784262 0.757 rs74655564 chr15:58325512 G/C cg12031962 chr15:58353849 ALDH1A2 -0.35 -5.3 -0.31 2.39e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs593982 0.858 rs537385 chr11:65504900 G/A cg08755490 chr11:65554678 OVOL1 1.31 20.14 0.78 2.41e-55 Atopic dermatitis; CESC cis rs11792861 0.926 rs72607166 chr9:111821530 A/C cg05043794 chr9:111880884 C9orf5 -0.39 -6.38 -0.37 7.75e-10 Menarche (age at onset); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg23248324 chr6:80714171 TTK -0.42 -6.01 -0.35 5.97e-9 Gut microbiota (bacterial taxa); CESC trans rs7107217 1.000 rs1873872 chr11:129473993 A/T cg01708236 chr6:44233446 NFKBIE 0.49 6.32 0.36 1.08e-9 Breast cancer;Type 2 diabetes; CESC cis rs1670533 1.000 rs6852155 chr4:1067638 T/G cg04106633 chr4:1044584 NA 0.42 5.35 0.31 1.94e-7 Recombination rate (females); CESC cis rs6991838 0.584 rs66467166 chr8:66486400 C/A cg13398993 chr8:66546079 ARMC1 -0.45 -5.54 -0.32 7.3900000000000007e-08 Intelligence (multi-trait analysis); CESC cis rs10744422 1.000 rs2292135 chr12:123334075 G/A cg25930673 chr12:123319894 HIP1R -0.72 -5.73 -0.33 2.79e-8 Schizophrenia; CESC trans rs7863342 0.766 rs28508550 chr9:71423303 T/C cg09576762 chr15:99548859 LOC145814 -0.32 -6.18 -0.35 2.47e-9 Cancer; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26652484 chr3:57582327 ARF4 -0.44 -6.2 -0.36 2.13e-9 Asthma; CESC trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -6.42 -0.37 6.19e-10 Neuroticism; CESC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg22903471 chr2:27725779 GCKR -0.57 -8.2 -0.45 1.04e-14 Total body bone mineral density; CESC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg11494091 chr17:61959527 GH2 -0.8 -14.94 -0.68 5e-37 Prudent dietary pattern; CESC cis rs11997175 0.603 rs7464072 chr8:33776973 G/A ch.8.33884649F chr8:33765107 NA 0.53 6.85 0.39 5.24e-11 Body mass index; CESC cis rs7617773 1.000 rs12496784 chr3:48186267 C/T cg11946769 chr3:48343235 NME6 -0.61 -8.11 -0.45 1.84e-14 Coronary artery disease; CESC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.57 0.32 6.31e-8 Bipolar disorder; CESC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.55 0.42 7.15e-13 Bipolar disorder; CESC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg07092213 chr7:1199455 ZFAND2A -0.41 -5.33 -0.31 2.09e-7 Longevity;Endometriosis; CESC cis rs9287719 0.967 rs4669599 chr2:10758029 T/C cg02196655 chr2:10830764 NOL10 -0.37 -5.67 -0.33 3.73e-8 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17979991 chr7:43769177 C7orf44 0.62 7.28 0.41 3.75e-12 Gut microbiome composition (summer); CESC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg03806693 chr22:41940476 POLR3H -1.19 -15.04 -0.68 2.19e-37 Vitiligo; CESC cis rs7223966 1.000 rs6504173 chr17:61735056 T/C cg11494091 chr17:61959527 GH2 0.38 5.42 0.32 1.34e-7 Hip circumference adjusted for BMI;Body mass index; CESC cis rs863345 0.967 rs7511912 chr1:158531808 C/T cg12129480 chr1:158549410 OR10X1 -0.33 -6.64 -0.38 1.74e-10 Pneumococcal bacteremia; CESC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg17971929 chr21:40555470 PSMG1 1.08 16.22 0.71 1.49e-41 Cognitive function; CESC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg19622623 chr12:86230825 RASSF9 -0.46 -5.89 -0.34 1.2e-8 Major depressive disorder; CESC cis rs250677 0.641 rs2915807 chr5:148450950 A/G cg18129178 chr5:148520854 ABLIM3 -0.6 -6.05 -0.35 4.91e-9 Breast cancer; CESC cis rs10944 0.584 rs1422086 chr5:78374865 G/T cg22188827 chr5:78429774 NA -0.4 -5.44 -0.32 1.18e-7 Blood and toenail selenium levels; CESC cis rs3806843 0.966 rs10053945 chr5:140160127 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.18 -0.3 4.31e-7 Depressive symptoms (multi-trait analysis); CESC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg13175981 chr1:150552382 MCL1 0.44 5.31 0.31 2.31e-7 Blood protein levels; CESC cis rs4654899 0.758 rs6426667 chr1:21396216 C/A cg05370193 chr1:21551575 ECE1 0.35 5.33 0.31 2.05e-7 Superior frontal gyrus grey matter volume; CESC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg08704250 chr15:31115839 NA -0.63 -8.15 -0.45 1.48e-14 Huntington's disease progression; CESC cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg15017067 chr4:17643749 FAM184B 0.36 5.12 0.3 5.83e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9457247 0.871 rs1811121 chr6:167403539 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.83 0.34 1.58e-8 Crohn's disease; CESC cis rs17655565 0.636 rs59951029 chr12:52716607 G/T cg08257133 chr12:52711352 KRT83 0.37 5.22 0.31 3.58e-7 Plasma amyloid beta peptide concentrations (ABx-42); CESC cis rs4595586 0.545 rs3858553 chr12:39381291 A/C cg26384229 chr12:38710491 ALG10B 0.62 8.69 0.47 3.89e-16 Morning vs. evening chronotype; CESC cis rs936229 0.861 rs3935077 chr15:75120211 C/G cg14664628 chr15:75095509 CSK -0.99 -15.48 -0.69 5.95e-39 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CESC cis rs13256369 0.802 rs13281933 chr8:8562665 C/A cg17143192 chr8:8559678 CLDN23 0.76 8.71 0.47 3.26e-16 Obesity-related traits; CESC cis rs6831352 0.918 rs13140423 chr4:100050400 T/C cg12011299 chr4:100065546 ADH4 -0.59 -6.52 -0.37 3.62e-10 Alcohol dependence; CESC trans rs2727020 0.521 rs10839285 chr11:49496852 T/G cg15704280 chr7:45808275 SEPT13 0.81 10.48 0.54 9.66e-22 Coronary artery disease; CESC cis rs9868809 0.881 rs7620853 chr3:48666503 G/A cg07636037 chr3:49044803 WDR6 -0.64 -5.32 -0.31 2.21e-7 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CESC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg18402987 chr7:1209562 NA 0.4 5.18 0.3 4.48e-7 Longevity;Endometriosis; CESC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg17971929 chr21:40555470 PSMG1 1.08 16.28 0.71 9.03e-42 Cognitive function; CESC cis rs6500395 0.962 rs11647046 chr16:48623217 T/C cg04672837 chr16:48644449 N4BP1 0.47 5.82 0.34 1.72e-8 Response to tocilizumab in rheumatoid arthritis; CESC cis rs4700695 0.719 rs27078 chr5:65445331 G/C cg21114390 chr5:65439923 SFRS12 -0.5 -6.14 -0.35 2.99e-9 Facial morphology (factor 19); CESC cis rs6456156 0.819 rs7765739 chr6:167518472 C/T cg07741184 chr6:167504864 NA 0.36 6.42 0.37 6.34e-10 Primary biliary cholangitis; CESC cis rs7692995 1.000 rs12506752 chr4:17948352 G/A cg08925142 chr4:18023851 LCORL -0.44 -5.1 -0.3 6.36e-7 Height; CESC cis rs9467711 0.606 rs9379897 chr6:26601526 T/C cg21479132 chr6:26055353 NA 0.58 5.18 0.3 4.44e-7 Autism spectrum disorder or schizophrenia; CESC cis rs904092 0.720 rs1229967 chr4:100207578 G/C cg12011299 chr4:100065546 ADH4 -0.54 -6.16 -0.35 2.76e-9 Alcohol dependence; CESC cis rs11792861 0.926 rs72607170 chr9:111836941 G/A cg05043794 chr9:111880884 C9orf5 -0.41 -6.74 -0.38 9.83e-11 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26381918 chr2:99225517 C2orf64;UNC50 -0.52 -6.1 -0.35 3.7e-9 Gut microbiome composition (summer); CESC cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg05340658 chr4:99064831 C4orf37 0.83 12.74 0.62 2.5e-29 Colonoscopy-negative controls vs population controls; CESC cis rs7116495 1.000 rs2298457 chr11:71734211 T/C cg26138937 chr11:71823887 C11orf51 -0.77 -6.19 -0.36 2.3e-9 Severe influenza A (H1N1) infection; CESC cis rs765787 0.530 rs2668737 chr15:45522799 C/T cg24006582 chr15:45444508 DUOX1 -0.59 -7.11 -0.4 1.09e-11 Uric acid levels; CESC cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg03676636 chr4:99064102 C4orf37 0.34 5.22 0.31 3.6e-7 Colonoscopy-negative controls vs population controls; CESC cis rs9488822 0.676 rs11757115 chr6:116362619 C/T cg18764771 chr6:116381957 FRK 0.23 5.73 0.33 2.66e-8 Cholesterol, total;LDL cholesterol; CESC cis rs9549328 0.885 rs3011547 chr13:113635963 C/T cg22951483 chr13:113628068 MCF2L 0.33 5.27 0.31 2.89e-7 Systolic blood pressure; CESC cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg14784868 chr12:69753453 YEATS4 0.84 13.09 0.63 1.52e-30 Blood protein levels; CESC cis rs1215050 0.743 rs6532692 chr4:98648005 C/A cg05340658 chr4:99064831 C4orf37 -0.48 -6.22 -0.36 1.89e-9 Waist-to-hip ratio adjusted for body mass index; CESC cis rs250677 0.522 rs10042466 chr5:148393634 T/C cg18129178 chr5:148520854 ABLIM3 -0.47 -5.33 -0.31 2.08e-7 Breast cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09549848 chr9:113800279 LPAR1 -0.51 -6.08 -0.35 4.2e-9 Gut microbiome composition (summer); CESC cis rs2617583 0.599 rs2975226 chr5:1445616 A/T cg07151155 chr5:1473589 LPCAT1 -0.34 -5.28 -0.31 2.76e-7 Breast cancer; CESC cis rs1348850 0.632 rs13008857 chr2:178514468 G/A cg22681709 chr2:178499509 PDE11A -0.58 -9.09 -0.49 2.35e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg12718519 chr1:2058417 PRKCZ 0.25 5.24 0.31 3.23e-7 Height; CESC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg07701084 chr6:150067640 NUP43 0.47 6.61 0.38 2.06e-10 Lung cancer; CESC cis rs2295499 0.643 rs4690088 chr4:2698865 C/T cg27239842 chr4:2403781 ZFYVE28 -0.32 -5.27 -0.31 2.82e-7 Cognitive ability;Cognitive ability (multi-trait analysis);Intelligence (multi-trait analysis); CESC cis rs5769765 1.000 rs910800 chr22:50278642 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.46 5.32 0.31 2.21e-7 Schizophrenia; CESC cis rs911555 0.662 rs4906322 chr14:103879032 A/G cg12935359 chr14:103987150 CKB 0.6 8.91 0.48 8.49e-17 Intelligence (multi-trait analysis); CESC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -5.79 -0.33 2.01e-8 Tonsillectomy; CESC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg21963583 chr11:68658836 MRPL21 0.39 5.39 0.31 1.58e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg17724175 chr1:150552817 MCL1 0.45 7.19 0.4 6.49e-12 Tonsillectomy; CESC cis rs2933343 1.000 rs1680795 chr3:128620388 T/C cg25356066 chr3:128598488 ACAD9 0.6 7.25 0.41 4.55e-12 IgG glycosylation; CESC cis rs8067354 0.574 rs2531898 chr17:58012351 G/C cg13753209 chr17:57696993 CLTC 0.54 5.76 0.33 2.28e-8 Hemoglobin concentration; CESC cis rs2204008 0.745 rs8189516 chr12:38239084 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.1 0.35 3.78e-9 Bladder cancer; CESC cis rs13034020 0.522 rs35976602 chr2:61241582 G/C cg18625361 chr2:61244694 PEX13;PUS10 0.66 5.9 0.34 1.13e-8 Hodgkin's lymphoma; CESC cis rs9467773 0.595 rs7767847 chr6:26597893 A/T cg26531700 chr6:26746687 NA -0.42 -6.43 -0.37 6.02e-10 Intelligence (multi-trait analysis); CESC cis rs12618769 0.597 rs3769740 chr2:99069208 A/G cg10123293 chr2:99228465 UNC50 -0.4 -5.44 -0.32 1.18e-7 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08187083 chr17:30186506 C17orf79 0.63 7.03 0.4 1.77e-11 Gut microbiome composition (summer); CESC cis rs7208859 0.673 rs56846352 chr17:29119188 C/T cg19761014 chr17:28927070 LRRC37B2 0.68 6.72 0.38 1.11e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs2073300 1.000 rs79169006 chr20:23443535 A/T cg12062639 chr20:23401060 NAPB 0.91 6.41 0.37 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg14393609 chr7:65229607 NA -0.45 -5.88 -0.34 1.24e-8 Aortic root size; CESC trans rs4942242 0.602 rs61960076 chr13:44217784 T/C cg19169023 chr15:41853346 TYRO3 -0.61 -7.72 -0.43 2.46e-13 Response to tocilizumab in rheumatoid arthritis; CESC cis rs6938 0.563 rs12917376 chr15:75116167 C/T cg09165964 chr15:75287851 SCAMP5 0.53 7.18 0.4 7.12e-12 Breast cancer; CESC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg19163074 chr7:65112434 INTS4L2 0.43 5.51 0.32 8.54e-8 Aortic root size; CESC cis rs12618769 0.597 rs2278206 chr2:99172244 A/G cg10123293 chr2:99228465 UNC50 0.4 5.27 0.31 2.77e-7 Bipolar disorder; CESC cis rs10744422 0.858 rs12426809 chr12:123327143 C/T cg25930673 chr12:123319894 HIP1R -0.65 -5.28 -0.31 2.72e-7 Schizophrenia; CESC cis rs8180040 0.966 rs13079098 chr3:47442863 A/G cg27129171 chr3:47204927 SETD2 0.65 10.14 0.53 1.22e-20 Colorectal cancer; CESC cis rs12145833 0.596 rs61833913 chr1:243440028 C/G cg02356786 chr1:243265016 LOC731275 0.75 5.66 0.33 3.99e-8 Obesity (early onset extreme); CESC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg07395648 chr5:131743802 NA -0.43 -5.27 -0.31 2.77e-7 Breast cancer;Mosquito bite size; CESC cis rs9303401 0.614 rs28651036 chr17:57080471 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.89 11.09 0.56 9.68e-24 Cognitive test performance; CESC cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg02297831 chr4:17616191 MED28 0.44 5.34 0.31 1.99e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs2276314 0.947 rs4799831 chr18:33554775 A/G cg05985134 chr18:33552581 C18orf21 0.65 7.5 0.42 9.76e-13 Endometriosis;Drug-induced torsades de pointes; CESC cis rs17376456 0.877 rs28633397 chr5:93447048 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.62 5.44 0.32 1.23e-7 Diabetic retinopathy; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg09292409 chr16:15461083 NA -0.37 -6.14 -0.35 2.95e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6032067 0.561 rs2743317 chr20:43936931 C/T cg10761708 chr20:43804764 PI3 0.44 5.37 0.31 1.69e-7 Blood protein levels; CESC trans rs3780486 0.718 rs73645257 chr9:33132354 C/T cg04842962 chr6:43655489 MRPS18A 0.76 9.1 0.49 2.28e-17 IgG glycosylation; CESC cis rs11809207 0.523 rs12565756 chr1:26498196 G/T cg00147160 chr1:26503991 CNKSR1 0.27 5.23 0.31 3.39e-7 Height; CESC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.5 0.37 3.92e-10 Bipolar disorder; CESC cis rs12410462 0.502 rs78101727 chr1:227732069 C/T cg04117972 chr1:227635322 NA 0.75 5.13 0.3 5.66e-7 Major depressive disorder; CESC cis rs6500395 1.000 rs11640463 chr16:48644434 A/T cg04672837 chr16:48644449 N4BP1 0.5 6.07 0.35 4.3e-9 Response to tocilizumab in rheumatoid arthritis; CESC cis rs3820068 0.603 rs3795763 chr1:15959977 C/T cg13390004 chr1:15929781 NA 0.37 5.89 0.34 1.18e-8 Systolic blood pressure; CESC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg13206674 chr6:150067644 NUP43 0.41 5.77 0.33 2.21e-8 Lung cancer; CESC cis rs6460942 0.643 rs7780093 chr7:12233661 C/G cg06484146 chr7:12443880 VWDE -0.47 -5.22 -0.31 3.54e-7 Coronary artery disease; CESC cis rs9309473 0.583 rs6709853 chr2:73576065 T/A cg20560298 chr2:73613845 ALMS1 -0.45 -6.38 -0.36 8.06e-10 Metabolite levels; CESC cis rs28374715 0.681 rs7168307 chr15:41620534 A/G cg02330683 chr15:41787940 ITPKA 0.5 6.79 0.39 7.21e-11 Ulcerative colitis; CESC cis rs10905065 0.931 rs6602240 chr10:5816751 C/A cg11519256 chr10:5708881 ASB13 -0.43 -5.42 -0.32 1.34e-7 Menopause (age at onset); CESC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg07167872 chr1:205819463 PM20D1 0.59 9.59 0.51 6.88e-19 Monocyte percentage of white cells; CESC cis rs7264396 0.635 rs6060656 chr20:34466382 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.84 -11.47 -0.58 5.38e-25 Total cholesterol levels; CESC cis rs634534 0.622 rs593525 chr11:65727799 T/C cg04055107 chr11:65626734 MUS81;CFL1 0.44 5.5 0.32 8.98e-8 Sum eosinophil basophil counts;Eosinophil counts; CESC cis rs12137294 0.761 rs1172150 chr1:205221861 A/G cg21643547 chr1:205240462 TMCC2 -0.34 -5.46 -0.32 1.09e-7 Red cell distribution width; CESC cis rs17539620 0.624 rs74551216 chr6:154840524 T/C cg17771515 chr6:154831774 CNKSR3 0.55 5.25 0.31 3.1e-7 Lipoprotein (a) levels; CESC cis rs2040771 0.745 rs361956 chr22:19265799 C/T cg02655711 chr22:19163373 SLC25A1 0.4 5.8 0.34 1.93e-8 Metabolite levels (small molecules and protein measures); CESC cis rs477692 0.699 rs576175 chr10:131386408 A/T cg05714579 chr10:131428358 MGMT 0.42 5.51 0.32 8.29e-8 Response to temozolomide; CESC cis rs17253792 0.822 rs12100949 chr14:56040787 T/C cg01858014 chr14:56050164 KTN1 -0.88 -7.51 -0.42 9.24e-13 Putamen volume; CESC cis rs7520050 0.966 rs785488 chr1:46576095 G/A cg03146154 chr1:46216737 IPP -0.43 -5.57 -0.32 6.33e-8 Red blood cell count;Reticulocyte count; CESC cis rs9300255 0.568 rs1790090 chr12:123633424 G/A cg05973401 chr12:123451056 ABCB9 0.51 5.72 0.33 2.81e-8 Neutrophil percentage of white cells; CESC cis rs7044106 0.791 rs10760116 chr9:123494681 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.88 14.59 0.67 8.79e-36 Hip circumference adjusted for BMI; CESC cis rs9300255 0.739 rs1969354 chr12:123741776 T/C cg05973401 chr12:123451056 ABCB9 0.49 5.52 0.32 8.03e-8 Neutrophil percentage of white cells; CESC cis rs4132509 1.000 rs73128287 chr1:243952150 T/G cg21452805 chr1:244014465 NA 0.53 6.55 0.37 2.97e-10 RR interval (heart rate); CESC cis rs3857067 0.901 rs965807 chr4:95045567 G/T cg11021082 chr4:95130006 SMARCAD1 -0.52 -7.87 -0.44 9.02e-14 QT interval; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg01089097 chr15:37110495 CSNK1A1P -0.5 -6.41 -0.37 6.81e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg24060327 chr5:131705240 SLC22A5 -0.78 -10.98 -0.56 2.29e-23 Breast cancer; CESC cis rs12101261 0.580 rs3783949 chr14:81448382 A/C cg06600135 chr14:81408086 NA 0.39 5.3 0.31 2.49e-7 Graves' disease; CESC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg05564831 chr3:52568323 NT5DC2 0.44 6.72 0.38 1.08e-10 Intelligence (multi-trait analysis); CESC trans rs9929218 0.953 rs34909703 chr16:68740097 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -10.54 -0.54 6.34e-22 Colorectal cancer; CESC cis rs67311347 0.869 rs6790495 chr3:40366770 C/T cg24209194 chr3:40518798 ZNF619 0.4 5.03 0.3 9.09e-7 Renal cell carcinoma; CESC cis rs9818941 1.000 rs9845687 chr3:157682536 T/C cg08654915 chr3:157813417 NA -0.46 -7.74 -0.43 2.07e-13 Height; CESC cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg27347728 chr4:17578864 LAP3 -0.45 -5.27 -0.31 2.76e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6942756 0.688 rs2718089 chr7:128927022 G/T cg02491457 chr7:128862824 NA 0.62 8.66 0.47 4.73e-16 White matter hyperintensity burden; CESC cis rs12824058 0.831 rs11060825 chr12:130807905 A/G cg24838063 chr12:130822603 PIWIL1 0.61 8.34 0.46 4.03e-15 Menopause (age at onset); CESC cis rs116095464 0.558 rs10057674 chr5:266813 C/T cg12570787 chr5:219185 SDHA;CCDC127 0.53 5.49 0.32 9.44e-8 Breast cancer; CESC cis rs7208859 0.673 rs9899525 chr17:29120296 T/A cg19761014 chr17:28927070 LRRC37B2 0.77 6.38 0.36 7.79e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs9814567 0.752 rs7623567 chr3:134330976 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -5.09 -0.3 6.84e-7 Neurocognitive impairment in HIV-1 infection (dichotomous); CESC cis rs916888 0.821 rs199512 chr17:44857352 T/C cg14517863 chr17:44321492 NA -0.4 -5.16 -0.3 4.82e-7 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg24034477 chr20:35202059 TGIF2 -0.44 -6.25 -0.36 1.61e-9 Prostate cancer (SNP x SNP interaction); CESC cis rs2249694 1.000 rs2480259 chr10:135352076 A/G cg20169779 chr10:135381914 SYCE1 0.39 5.2 0.3 3.9e-7 Obesity-related traits; CESC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg04944784 chr2:26401820 FAM59B -0.63 -7.27 -0.41 3.93e-12 Gut microbiome composition (summer); CESC cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg16743903 chr16:89593216 SPG7 0.4 5.3 0.31 2.41e-7 Multiple myeloma (IgH translocation); CESC cis rs6543140 0.964 rs6748390 chr2:103062175 A/G cg04239558 chr2:103089729 SLC9A4 0.46 5.59 0.32 5.62e-8 Blood protein levels; CESC cis rs155076 0.711 rs4770131 chr13:21897468 A/G cg11317459 chr13:21872234 NA 1.31 15.08 0.68 1.61e-37 White matter hyperintensity burden; CESC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.24 0.41 4.76e-12 Bipolar disorder; CESC cis rs250677 0.522 rs4431331 chr5:148353574 A/C cg18129178 chr5:148520854 ABLIM3 -0.46 -5.22 -0.31 3.67e-7 Breast cancer; CESC cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg14061069 chr19:46274453 DMPK -0.38 -5.26 -0.31 2.92e-7 Coronary artery disease; CESC cis rs854765 0.547 rs9912096 chr17:17896673 A/C cg09796270 chr17:17721594 SREBF1 0.4 5.57 0.32 6.1e-8 Total body bone mineral density; CESC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg07701084 chr6:150067640 NUP43 0.43 5.83 0.34 1.62e-8 Lung cancer; CESC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg09359103 chr1:154839909 KCNN3 0.4 6.35 0.36 9.15e-10 Schizophrenia; CESC cis rs2599510 0.934 rs2710634 chr2:32808804 T/C cg02381751 chr2:32503542 YIPF4 0.6 8.21 0.45 9.63e-15 Interleukin-18 levels; CESC cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.82 8.75 0.47 2.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs12142240 0.698 rs61519400 chr1:46855298 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.3 0.45 5.19e-15 Menopause (age at onset); CESC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg06634786 chr22:41940651 POLR3H -0.7 -7.4 -0.41 1.85e-12 Vitiligo; CESC cis rs1577917 0.958 rs12199832 chr6:86652748 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.86 -0.34 1.4e-8 Response to antipsychotic treatment; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03564166 chr16:70380888 DDX19A -0.5 -6.6 -0.38 2.2e-10 Fibrinogen levels; CESC cis rs36051895 0.664 rs62541915 chr9:5151275 A/T cg02405213 chr9:5042618 JAK2 -0.48 -5.49 -0.32 9.46e-8 Pediatric autoimmune diseases; CESC cis rs17001868 0.568 rs9607701 chr22:40739116 A/G cg07138101 chr22:40742427 ADSL 0.57 5.38 0.31 1.66e-7 Mammographic density (dense area); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg26120617 chr12:6603256 NCAPD2;MRPL51 0.48 6.12 0.35 3.39e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs17376456 0.825 rs36042718 chr5:93180997 C/T cg21475434 chr5:93447410 FAM172A 0.84 7.45 0.42 1.35e-12 Diabetic retinopathy; CESC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg19318889 chr4:1322082 MAEA 0.65 7.77 0.43 1.77e-13 Longevity; CESC cis rs9354308 0.770 rs2802048 chr6:66525044 C/G cg07460842 chr6:66804631 NA 0.51 5.57 0.32 6.27e-8 Metabolite levels; CESC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg22963979 chr7:1858916 MAD1L1 -0.38 -5.12 -0.3 6e-7 Bipolar disorder and schizophrenia; CESC cis rs2832191 0.791 rs2832196 chr21:30497412 G/A cg08807101 chr21:30365312 RNF160 -0.72 -9.88 -0.52 8.5e-20 Dental caries; CESC cis rs854765 0.618 rs9908017 chr17:17774422 C/T cg16928487 chr17:17741425 SREBF1 0.59 10.61 0.55 3.78e-22 Total body bone mineral density; CESC cis rs1707322 0.638 rs9429095 chr1:46603348 A/C cg03146154 chr1:46216737 IPP -0.59 -7.13 -0.4 9.48e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs10733682 0.659 rs13292976 chr9:129467340 C/T cg00232160 chr9:129468157 NA 0.37 5.99 0.35 6.91e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg21248554 chr2:27665150 KRTCAP3 0.33 6.59 0.38 2.43e-10 Total body bone mineral density; CESC cis rs67478160 0.643 rs8003653 chr14:104298836 A/G cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.21 -0.41 5.78e-12 Schizophrenia; CESC cis rs10276381 0.786 rs28430601 chr7:28238811 A/G cg23620719 chr7:28220237 JAZF1 0.66 6.22 0.36 1.96e-9 Crohn's disease; CESC cis rs12410462 1.000 rs76233861 chr1:227673909 G/A cg04117972 chr1:227635322 NA 0.65 6.28 0.36 1.38e-9 Major depressive disorder; CESC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg12463550 chr7:65579703 CRCP 0.49 6.17 0.35 2.57e-9 Aortic root size; CESC cis rs10779751 0.734 rs1194820 chr1:11129259 A/C cg08854313 chr1:11322531 MTOR 0.8 11.54 0.58 3.1e-25 Body mass index; CESC cis rs854765 0.583 rs4925123 chr17:17784374 A/G cg04398451 chr17:18023971 MYO15A 0.62 8.7 0.47 3.63e-16 Total body bone mineral density; CESC cis rs1707322 0.896 rs785512 chr1:46534543 A/G cg03146154 chr1:46216737 IPP -0.7 -9.2 -0.49 1.08e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs3008870 1.000 rs3008874 chr1:67431365 A/T cg08660285 chr1:67390436 MIER1;WDR78 1.06 15.19 0.68 6.65e-38 Lymphocyte percentage of white cells; CESC cis rs9929218 0.954 rs34530130 chr16:68827620 C/T cg02972257 chr16:68554789 NA 0.45 5.28 0.31 2.69e-7 Colorectal cancer; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg04275040 chr17:78936628 RPTOR 0.44 6.81 0.39 6.66e-11 Fibrinogen levels; CESC cis rs7647973 0.925 rs6446257 chr3:49253492 A/G cg07636037 chr3:49044803 WDR6 -0.67 -8.68 -0.47 4.07e-16 Menarche (age at onset); CESC trans rs7618501 0.633 rs55751738 chr3:49972101 A/G cg21659725 chr3:3221576 CRBN 0.49 6.81 0.39 6.69e-11 Intelligence (multi-trait analysis); CESC cis rs2108622 0.701 rs118144071 chr19:15979194 A/G cg13772218 chr19:15982569 NA 0.29 5.56 0.32 6.47e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05617973 chr19:49468917 FTL 0.58 6.53 0.37 3.43e-10 Gut microbiome composition (summer); CESC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg11644478 chr21:40555479 PSMG1 -0.83 -12.84 -0.62 1.17e-29 Cognitive function; CESC cis rs3015497 0.608 rs3015499 chr14:51112460 T/C cg26011998 chr14:51135199 SAV1 -0.6 -6.73 -0.38 1.02e-10 Mean platelet volume; CESC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg04944784 chr2:26401820 FAM59B -0.87 -9.24 -0.49 8.34e-18 Gut microbiome composition (summer); CESC trans rs923375 1.000 rs923375 chr17:3393068 C/T cg21315798 chr22:50354594 PIM3 0.47 6.09 0.35 3.96e-9 Myopia (pathological); CESC cis rs3772130 0.564 rs28760466 chr3:121601510 A/G cg20356878 chr3:121714668 ILDR1 0.42 6.17 0.35 2.54e-9 Cognitive performance; CESC trans rs11039798 0.778 rs7944523 chr11:48911019 G/A cg15704280 chr7:45808275 SEPT13 0.69 6.44 0.37 5.66e-10 Axial length; CESC cis rs11214589 0.651 rs17600713 chr11:113259947 C/T cg14159747 chr11:113255604 NA 0.35 6.22 0.36 1.89e-9 Neuroticism; CESC cis rs155076 1.000 rs564685 chr13:21846879 A/G cg11317459 chr13:21872234 NA -1.05 -11.58 -0.58 2.37e-25 White matter hyperintensity burden; CESC cis rs7193541 0.684 rs9929496 chr16:74668473 G/A cg01733217 chr16:74700730 RFWD3 1.06 20.92 0.79 4.64e-58 Multiple myeloma; CESC cis rs796364 1.000 rs71424239 chr2:200725473 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.81 -6.33 -0.36 1.03e-9 Schizophrenia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg15798279 chr7:6523691 KDELR2 0.47 6.5 0.37 4.08e-10 Systemic lupus erythematosus; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg14212983 chr1:21985742 RAP1GAP -0.41 -6.59 -0.38 2.43e-10 Gambling; CESC cis rs17783634 0.509 rs11775489 chr8:11036843 T/C cg21775007 chr8:11205619 TDH -0.39 -5.03 -0.3 9.07e-7 Subjective well-being; CESC cis rs2404602 0.692 rs34287706 chr15:76942402 A/C cg22467129 chr15:76604101 ETFA -0.35 -5.21 -0.3 3.89e-7 Blood metabolite levels; CESC cis rs12136530 0.593 rs2314145 chr1:19736843 C/G cg01832549 chr1:19774989 CAPZB -0.44 -6.23 -0.36 1.85e-9 Lead levels in blood; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg25467969 chr19:17337038 OCEL1 0.56 6.6 0.38 2.23e-10 Gut microbiome composition (summer); CESC cis rs4423214 1.000 rs4944946 chr11:71159429 G/A cg05163923 chr11:71159392 DHCR7 0.85 12.11 0.6 3.72e-27 Vitamin D levels; CESC cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg17211192 chr8:82754475 SNX16 0.7 8.32 0.46 4.71e-15 Diastolic blood pressure; CESC cis rs7666738 0.830 rs1456208 chr4:98678563 C/T cg05340658 chr4:99064831 C4orf37 0.75 10.76 0.55 1.19e-22 Colonoscopy-negative controls vs population controls; CESC cis rs4077515 0.504 rs10870164 chr9:139315682 C/T cg14169450 chr9:139327907 INPP5E -0.5 -7.49 -0.42 1.06e-12 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CESC cis rs2299587 0.554 rs3739404 chr8:17739843 C/A cg08627089 chr8:17753878 FGL1 -0.39 -5.56 -0.32 6.63e-8 Economic and political preferences; CESC cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.67 9.02 0.48 3.83e-17 Prudent dietary pattern; CESC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg16743903 chr16:89593216 SPG7 -0.47 -6.06 -0.35 4.72e-9 Multiple myeloma (IgH translocation); CESC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.08 0.4 1.32e-11 Height; CESC cis rs4919694 1.000 rs75691516 chr10:104652045 C/T cg04362960 chr10:104952993 NT5C2 0.74 6.45 0.37 5.32e-10 Arsenic metabolism; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21581312 chr15:35529473 LOC723972 0.47 6.54 0.37 3.12e-10 Fibrinogen levels; CESC cis rs72627509 0.951 rs17087335 chr4:57838583 G/T cg26694713 chr4:57773883 REST 0.56 5.36 0.31 1.82e-7 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CESC cis rs4722166 0.604 rs2390715 chr7:22783878 A/C cg13104385 chr7:22767384 IL6 0.48 6.36 0.36 8.89e-10 Lung cancer; CESC cis rs959260 0.623 rs4542691 chr17:73326965 T/C cg12999837 chr17:73267436 MIF4GD -0.41 -5.07 -0.3 7.31e-7 Systemic lupus erythematosus; CESC cis rs8017423 0.647 rs4904679 chr14:90821801 C/T cg14092571 chr14:90743983 NA 0.45 6.82 0.39 6.23e-11 Mortality in heart failure; CESC cis rs7084402 0.967 rs6481404 chr10:60286071 C/G cg07615347 chr10:60278583 BICC1 -0.56 -8.61 -0.47 6.75e-16 Refractive error; CESC cis rs6580649 0.783 rs1635526 chr12:48396785 C/T cg24011408 chr12:48396354 COL2A1 0.4 5.26 0.31 2.98e-7 Lung cancer; CESC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.5 6.46 0.37 4.93e-10 Tonsillectomy; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg12346351 chr4:152330392 FAM160A1 0.48 6.67 0.38 1.52e-10 Systemic lupus erythematosus; CESC cis rs2404602 0.716 rs66754747 chr15:76828568 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.72 -0.33 2.83e-8 Blood metabolite levels; CESC cis rs60733400 0.782 rs4648564 chr1:2562169 C/T cg20673091 chr1:2541236 MMEL1 -0.47 -7.91 -0.44 7.2e-14 Multiple sclerosis; CESC cis rs2735413 0.837 rs7194946 chr16:78095274 G/A cg04733911 chr16:78082701 NA 0.46 7.28 0.41 3.75e-12 Systolic blood pressure (alcohol consumption interaction); CESC cis rs2712184 0.756 rs2712182 chr2:217647525 T/C cg05032264 chr2:217675019 NA -0.34 -5.22 -0.31 3.65e-7 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg15084499 chr1:227505916 CDC42BPA -0.42 -6.17 -0.35 2.6e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs7659604 0.502 rs13106764 chr4:122699630 C/G cg19748678 chr4:122722346 EXOSC9 -0.43 -5.4 -0.31 1.49e-7 Type 2 diabetes; CESC cis rs9815354 0.556 rs116717051 chr3:42027411 G/C cg03022575 chr3:42003672 ULK4 0.75 6.64 0.38 1.72e-10 Pulse pressure;Diastolic blood pressure; CESC cis rs909002 0.849 rs2280386 chr1:32086912 A/C cg13919466 chr1:32135498 COL16A1 -0.49 -8.49 -0.46 1.51e-15 Intelligence (multi-trait analysis); CESC trans rs116095464 0.614 rs10061564 chr5:271329 T/C cg00938859 chr5:1591904 SDHAP3 0.64 6.95 0.39 2.88e-11 Breast cancer; CESC cis rs9388451 0.903 rs7758115 chr6:126061502 C/T cg10911889 chr6:126070802 HEY2 0.35 5.04 0.3 8.47e-7 Brugada syndrome; CESC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg21724239 chr8:58056113 NA 0.57 5.76 0.33 2.29e-8 Developmental language disorder (linguistic errors); CESC cis rs10883723 0.810 rs3818470 chr10:104263675 T/C cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg06481639 chr22:41940642 POLR3H -0.66 -6.81 -0.39 6.5500000000000006e-11 Vitiligo; CESC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg08859206 chr1:53392774 SCP2 0.54 7.12 0.4 1.03e-11 Monocyte count; CESC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg16132339 chr22:24313637 DDTL;DDT 0.4 6.17 0.35 2.54e-9 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs4803468 1.000 rs1043413 chr19:41939297 C/G cg14132834 chr19:41945861 ATP5SL 0.6 7.54 0.42 7.59e-13 Height; CESC cis rs2732480 0.523 rs34286639 chr12:48629044 C/T cg04545296 chr12:48745243 ZNF641 0.41 6.86 0.39 4.97e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CESC cis rs9325144 0.555 rs7960411 chr12:38703019 A/G cg26384229 chr12:38710491 ALG10B -0.6 -8.52 -0.46 1.19e-15 Morning vs. evening chronotype; CESC cis rs4588572 0.643 rs1560197 chr5:77768302 T/C cg11547950 chr5:77652471 NA -0.42 -5.31 -0.31 2.36e-7 Triglycerides; CESC cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -13.79 -0.65 5.61e-33 Lobe attachment (rater-scored or self-reported); CESC cis rs2795502 1.000 rs2796575 chr10:43374911 A/G cg20628663 chr10:43360327 NA 0.59 6.84 0.39 5.53e-11 Blood protein levels; CESC cis rs66887589 0.616 rs11732621 chr4:120212883 A/C cg09307838 chr4:120376055 NA 0.65 9.09 0.49 2.44e-17 Diastolic blood pressure; CESC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg07308232 chr7:1071921 C7orf50 -0.42 -5.68 -0.33 3.55e-8 Longevity;Endometriosis; CESC cis rs11098499 1.000 rs13435802 chr4:120177960 A/T cg09307838 chr4:120376055 NA -0.87 -11.73 -0.58 7.44e-26 Corneal astigmatism; CESC cis rs7937682 0.961 rs1784784 chr11:111483185 C/T cg09085632 chr11:111637200 PPP2R1B -0.91 -14.14 -0.66 3.37e-34 Primary sclerosing cholangitis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21959181 chr7:150755243 CDK5;SLC4A2 0.59 6.82 0.39 6.05e-11 Gut microbiome composition (summer); CESC cis rs6460942 0.908 rs112049544 chr7:12242551 A/G cg20607287 chr7:12443886 VWDE -0.58 -5.76 -0.33 2.36e-8 Coronary artery disease; CESC cis rs1707322 0.686 rs2230659 chr1:46078884 C/T cg03146154 chr1:46216737 IPP -0.79 -10.71 -0.55 1.73e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg09509183 chr1:209979624 IRF6 0.56 5.75 0.33 2.4e-8 Cleft lip with or without cleft palate; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg20376421 chr12:56546193 MYL6B 0.45 6.32 0.36 1.13e-9 Gut microbiota (bacterial taxa); CESC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.54 7.17 0.4 7.41e-12 Lymphocyte counts; CESC cis rs6674176 0.597 rs9326136 chr1:44390392 A/G cg12908607 chr1:44402522 ARTN 0.51 8.0 0.44 3.89e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg17221315 chr6:27791827 HIST1H4J -0.47 -5.39 -0.31 1.58e-7 Parkinson's disease; CESC cis rs2228479 0.850 rs12597299 chr16:89822364 C/A cg14709524 chr16:89940631 TCF25 0.93 6.94 0.39 3.03e-11 Skin colour saturation; CESC cis rs1448094 0.533 rs4412812 chr12:86151238 G/A cg02569458 chr12:86230093 RASSF9 -0.42 -6.37 -0.36 8.4e-10 Major depressive disorder; CESC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg02574844 chr11:5959923 NA -0.45 -6.47 -0.37 4.62e-10 DNA methylation (variation); CESC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg19622623 chr12:86230825 RASSF9 -0.44 -5.73 -0.33 2.79e-8 Major depressive disorder; CESC cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg20503657 chr10:835505 NA -0.7 -7.48 -0.42 1.07e-12 Eosinophil percentage of granulocytes; CESC cis rs713587 0.719 rs4665736 chr2:25187599 C/T cg01884057 chr2:25150051 NA -0.39 -7.42 -0.41 1.64e-12 Body mass index in non-asthmatics; CESC trans rs12310956 0.532 rs11052922 chr12:33957476 A/G cg26384229 chr12:38710491 ALG10B 0.48 6.68 0.38 1.37e-10 Morning vs. evening chronotype; CESC trans rs9388451 0.626 rs1343116 chr6:126069702 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.66 -9.31 -0.5 4.92e-18 Brugada syndrome; CESC cis rs2243480 1.000 rs35046236 chr7:65408613 T/C cg25894440 chr7:65020034 NA -0.59 -5.07 -0.3 7.57e-7 Diabetic kidney disease; CESC cis rs10876993 0.928 rs1678530 chr12:58054076 A/C cg18357645 chr12:58087776 OS9 0.6 9.29 0.5 6.03e-18 Celiac disease or Rheumatoid arthritis; CESC trans rs7047415 1.000 rs7873723 chr9:98543757 T/C cg00788170 chr1:227921688 SNAP47;LOC100130093;JMJD4 0.45 6.02 0.35 5.84e-9 Alzheimer disease and age of onset; CESC cis rs7945705 0.967 rs1569408 chr11:8909732 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.37 5.97 0.34 7.44e-9 Hemoglobin concentration; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg05602567 chr22:32871203 FBXO7 0.45 6.18 0.35 2.45e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs9811920 0.965 rs6767441 chr3:99863183 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.45 7.21 0.41 5.78e-12 Axial length; CESC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg05255149 chr17:80675120 FN3KRP 0.46 5.09 0.3 6.91e-7 Glycated hemoglobin levels; CESC cis rs4234798 0.546 rs4689667 chr4:7249188 A/T cg02658934 chr4:7637892 SORCS2 0.45 5.7 0.33 3.18e-8 Insulin-like growth factors; CESC cis rs73206853 0.841 rs57726856 chr12:110961123 T/C cg12870014 chr12:110450643 ANKRD13A 0.62 5.2 0.3 3.98e-7 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CESC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.68 0.43 3.15e-13 Prudent dietary pattern; CESC cis rs3087591 1.000 rs2854322 chr17:29699416 C/T cg24425628 chr17:29625626 OMG;NF1 0.46 5.84 0.34 1.51e-8 Hip circumference; CESC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.31 5.43 0.32 1.25e-7 Bipolar disorder; CESC cis rs7927592 0.871 rs11228284 chr11:68322767 A/T cg20283391 chr11:68216788 NA -0.61 -7.36 -0.41 2.26e-12 Total body bone mineral density; CESC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg10560079 chr2:191398806 TMEM194B 0.48 6.87 0.39 4.69e-11 Pulse pressure; CESC cis rs4319547 0.956 rs7397990 chr12:123119472 T/C cg05707623 chr12:122985044 ZCCHC8 -0.57 -6.83 -0.39 5.88e-11 Body mass index; CESC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg04166393 chr7:2884313 GNA12 0.57 7.37 0.41 2.16e-12 Height; CESC cis rs2933343 0.729 rs1680794 chr3:128620390 A/G cg25356066 chr3:128598488 ACAD9 0.58 7.92 0.44 6.4e-14 IgG glycosylation; CESC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg19077165 chr18:44547161 KATNAL2 -0.6 -9.21 -0.49 1.02e-17 Personality dimensions; CESC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg00149659 chr3:10157352 C3orf10 0.74 8.69 0.47 3.76e-16 Alzheimer's disease; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg20021244 chr5:139944115 APBB3;SLC35A4 0.41 6.18 0.35 2.34e-9 Gambling; CESC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg18758796 chr5:131593413 PDLIM4 0.38 5.24 0.31 3.35e-7 Breast cancer; CESC cis rs7223966 1.000 rs16947042 chr17:61766457 T/G cg11494091 chr17:61959527 GH2 0.39 5.5 0.32 9.15e-8 Hip circumference adjusted for BMI;Body mass index; CESC cis rs6912958 0.547 rs451089 chr6:88041859 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.45 7.91 0.44 7.05e-14 Monocyte percentage of white cells; CESC cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg11752832 chr7:134001865 SLC35B4 0.52 6.72 0.38 1.11e-10 Mean platelet volume; CESC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg23803603 chr1:2058230 PRKCZ -0.34 -5.8 -0.34 1.9e-8 Height; CESC trans rs5769765 0.955 rs9616367 chr22:50303515 A/C cg09872104 chr7:134855509 C7orf49 -0.54 -6.15 -0.35 2.77e-9 Schizophrenia; CESC cis rs858239 0.539 rs6975852 chr7:23186654 T/C cg23682824 chr7:23144976 KLHL7 0.46 5.85 0.34 1.45e-8 Cerebrospinal fluid biomarker levels; CESC cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg12927641 chr6:109611667 NA 0.43 6.73 0.38 1.06e-10 Reticulocyte fraction of red cells; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10311315 chr2:101889706 SNORD89 -0.56 -6.5 -0.37 3.91e-10 Gut microbiome composition (summer); CESC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg08499158 chr17:42289980 UBTF 0.49 6.34 0.36 9.7e-10 Total body bone mineral density; CESC cis rs6912958 0.559 rs242270 chr6:88062190 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.46 -8.17 -0.45 1.28e-14 Monocyte percentage of white cells; CESC cis rs6570726 0.935 rs416987 chr6:145847005 G/C cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.96e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs4450131 0.522 rs11245325 chr10:126348061 C/T cg20435097 chr10:126320824 FAM53B 0.29 5.17 0.3 4.6e-7 White blood cell count (basophil); CESC cis rs67311347 1.000 rs4973997 chr3:40460145 G/A cg09455208 chr3:40491958 NA 0.45 7.68 0.43 3.1e-13 Renal cell carcinoma; CESC cis rs7103648 0.897 rs2278890 chr11:47399602 G/A cg03711944 chr11:47377212 SPI1 -0.39 -6.06 -0.35 4.76e-9 Diastolic blood pressure;Systolic blood pressure; CESC cis rs6582630 0.519 rs11495700 chr12:38288240 A/G cg13010199 chr12:38710504 ALG10B 0.53 6.57 0.37 2.63e-10 Drug-induced liver injury (flucloxacillin); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24333206 chr3:140660642 SLC25A36 -0.56 -6.51 -0.37 3.72e-10 Gut microbiome composition (summer); CESC cis rs1707322 0.826 rs10890349 chr1:46249955 T/C cg06784218 chr1:46089804 CCDC17 0.37 6.34 0.36 1e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7809950 0.723 rs2237662 chr7:106874065 C/G cg23024343 chr7:107201750 COG5 -0.51 -6.73 -0.38 1.07e-10 Coronary artery disease; CESC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 6.45 0.37 5.19e-10 Bipolar disorder; CESC cis rs3820068 0.603 rs72647120 chr1:15956769 G/T cg17385448 chr1:15911702 AGMAT 0.41 6.63 0.38 1.86e-10 Systolic blood pressure; CESC cis rs28829049 0.597 rs1009806 chr1:19500551 T/C cg13387374 chr1:19411106 UBR4 0.45 5.8 0.34 1.88e-8 QRS duration in Tripanosoma cruzi seropositivity; CESC cis rs1538970 0.924 rs12046816 chr1:45891543 G/T cg05343316 chr1:45956843 TESK2 0.89 12.41 0.61 3.59e-28 Platelet count; CESC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg19046167 chr17:80928561 B3GNTL1 -0.47 -5.72 -0.33 2.86e-8 Glycated hemoglobin levels; CESC cis rs2735413 0.846 rs72800943 chr16:78079555 G/A cg04733911 chr16:78082701 NA -0.53 -9.01 -0.48 4.08e-17 Systolic blood pressure (alcohol consumption interaction); CESC cis rs6502050 0.835 rs9901076 chr17:80170020 G/A cg23985595 chr17:80112537 CCDC57 -0.42 -6.63 -0.38 1.9e-10 Life satisfaction; CESC cis rs10883723 0.810 rs7069356 chr10:104254359 G/C cg22532475 chr10:104410764 TRIM8 -0.34 -5.73 -0.33 2.77e-8 Allergic disease (asthma, hay fever or eczema); CESC cis rs5758659 1.000 rs134873 chr22:42657566 T/G cg15557168 chr22:42548783 NA -0.5 -7.87 -0.44 8.97e-14 Cognitive function; CESC cis rs9560113 0.556 rs9560128 chr13:112221924 A/G cg10483660 chr13:112241077 NA 0.43 7.13 0.4 9.81e-12 Menarche (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15540553 chr11:64018643 PLCB3 0.54 6.26 0.36 1.5e-9 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs4973898 chr3:40459532 A/G cg09455208 chr3:40491958 NA -0.47 -8.43 -0.46 2.23e-15 Renal cell carcinoma; CESC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg07507251 chr3:52567010 NT5DC2 0.42 7.32 0.41 2.95e-12 Bipolar disorder; CESC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -6.58 -0.37 2.56e-10 Bipolar disorder; CESC cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.34 -5.76 -0.33 2.35e-8 Hemoglobin concentration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09658066 chr6:35995354 MAPK14 0.54 6.26 0.36 1.57e-9 Gut microbiome composition (summer); CESC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg08736216 chr1:53307985 ZYG11A -0.4 -6.78 -0.38 7.66e-11 Monocyte count; CESC cis rs708547 0.957 rs781667 chr4:57798469 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.52 -5.4 -0.31 1.49e-7 Response to bleomycin (chromatid breaks); CESC cis rs2204008 0.840 rs7136347 chr12:38453531 G/A cg13010199 chr12:38710504 ALG10B 0.53 6.74 0.38 9.64e-11 Bladder cancer; CESC cis rs7520050 0.966 rs6675726 chr1:46560643 A/G cg03146154 chr1:46216737 IPP -0.43 -5.57 -0.32 6.38e-8 Red blood cell count;Reticulocyte count; CESC trans rs7726839 0.540 rs58599998 chr5:596087 A/G cg25482853 chr8:67687455 SGK3 1.04 10.08 0.53 1.87e-20 Obesity-related traits; CESC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg23281280 chr6:28129359 ZNF389 0.58 7.93 0.44 6.31e-14 Depression; CESC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg10819733 chr22:24237672 NA -0.46 -6.51 -0.37 3.67e-10 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg26939375 chr7:64535504 NA -0.44 -5.44 -0.32 1.24e-7 Aortic root size; CESC cis rs10883723 0.810 rs61873733 chr10:104251458 G/A ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.1 0.3 6.38e-7 Allergic disease (asthma, hay fever or eczema); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23888375 chr2:203776317 ALS2CR8;WDR12 0.53 6.61 0.38 2.15e-10 Gut microbiome composition (summer); CESC cis rs7666738 0.830 rs1120708 chr4:98931260 G/C cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs2304069 0.913 rs3812009 chr5:149380159 G/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.93 11.35 0.57 1.31e-24 HIV-1 control; CESC cis rs9486715 0.867 rs9486181 chr6:96868132 G/A cg06623918 chr6:96969491 KIAA0776 0.91 14.05 0.65 6.83e-34 Headache; CESC cis rs76878669 0.515 rs12576299 chr11:66132286 T/C cg18002602 chr11:66138449 SLC29A2 0.4 6.65 0.38 1.71e-10 Educational attainment (years of education); CESC cis rs72945132 0.882 rs7118156 chr11:70142922 T/C cg14191688 chr11:70257035 CTTN 0.42 5.34 0.31 1.95e-7 Coronary artery disease; CESC cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg08213375 chr14:104286397 PPP1R13B 0.33 5.41 0.32 1.42e-7 Reticulocyte count; CESC cis rs2281558 0.583 rs11087526 chr20:25648016 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.48 5.35 0.31 1.87e-7 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; CESC cis rs10751667 0.961 rs7396670 chr11:929269 A/G cg20946044 chr11:1010712 AP2A2 -0.42 -5.56 -0.32 6.59e-8 Alzheimer's disease (late onset); CESC cis rs2295359 0.892 rs12401432 chr1:67656931 C/G cg17031739 chr1:67600172 NA 0.41 5.48 0.32 9.94e-8 Psoriasis; CESC cis rs28830936 1.000 rs11632424 chr15:42095351 G/A cg11010575 chr15:42129464 JMJD7-PLA2G4B;JMJD7 -0.41 -5.59 -0.32 5.56e-8 Diastolic blood pressure; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg04370575 chr6:26537479 HMGN4 0.48 6.26 0.36 1.55e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg23281280 chr6:28129359 ZNF389 0.43 6.41 0.37 6.55e-10 Cardiac Troponin-T levels; CESC cis rs6582630 0.502 rs4385963 chr12:38295264 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.34 0.54 2.92e-21 Drug-induced liver injury (flucloxacillin); CESC cis rs1797885 0.934 rs1797889 chr3:12559386 T/G cg26432171 chr3:12704882 RAF1 -0.47 -5.84 -0.34 1.55e-8 Immature fraction of reticulocytes; CESC cis rs11626933 0.885 rs28517514 chr14:90788709 G/A cg14092571 chr14:90743983 NA -0.9 -14.89 -0.67 7.47e-37 Gut microbiota (bacterial taxa); CESC cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg04450456 chr4:17643702 FAM184B 0.36 5.15 0.3 5.16e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg12292205 chr6:26970375 C6orf41 -0.5 -5.72 -0.33 2.9e-8 Intelligence (multi-trait analysis); CESC cis rs10465746 0.967 rs6703382 chr1:84435700 G/A cg10977910 chr1:84465055 TTLL7 0.46 6.32 0.36 1.08e-9 Obesity-related traits; CESC cis rs2204008 0.614 rs4578492 chr12:38036350 T/C cg13010199 chr12:38710504 ALG10B 0.54 6.63 0.38 1.87e-10 Bladder cancer; CESC cis rs72829446 0.530 rs56078345 chr17:7394341 T/C cg02795151 chr17:7402630 POLR2A 0.55 5.83 0.34 1.63e-8 Androgen levels; CESC cis rs5498 0.869 rs2569702 chr19:10403947 A/G cg21994045 chr19:10403936 ICAM5 0.45 6.39 0.37 7.48e-10 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CESC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg03709012 chr19:19516395 GATAD2A 0.95 13.57 0.64 3.38e-32 Tonsillectomy; CESC cis rs17401966 0.838 rs946503 chr1:10308631 C/G cg15208524 chr1:10270712 KIF1B -0.4 -5.3 -0.31 2.4e-7 Hepatocellular carcinoma; CESC cis rs7512552 0.839 rs1260421 chr1:150357780 G/A cg15654264 chr1:150340011 RPRD2 0.39 5.17 0.3 4.68e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs3105593 0.547 rs3131559 chr15:50780214 C/A cg08437265 chr15:50716283 USP8 0.49 6.41 0.37 6.65e-10 QT interval; CESC cis rs4308124 0.708 rs6727313 chr2:111971540 G/A cg04571233 chr2:111982156 NA -0.62 -6.8 -0.39 6.82e-11 Vitiligo; CESC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg11764359 chr7:65958608 NA 0.69 9.1 0.49 2.27e-17 Aortic root size; CESC cis rs3733585 0.673 rs4311316 chr4:9955971 A/C cg11266682 chr4:10021025 SLC2A9 0.54 9.94 0.52 5.31e-20 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg18099408 chr3:52552593 STAB1 -0.31 -5.18 -0.3 4.4e-7 Bipolar disorder; CESC cis rs7666738 0.677 rs13120306 chr4:99036099 A/T cg05340658 chr4:99064831 C4orf37 0.82 12.42 0.61 3.27e-28 Colonoscopy-negative controls vs population controls; CESC cis rs4144027 0.967 rs10133399 chr14:104361843 A/T cg08213375 chr14:104286397 PPP1R13B 0.28 5.09 0.3 6.88e-7 Blood metabolite levels; CESC cis rs2243480 1.000 rs383402 chr7:65586653 A/C cg18252515 chr7:66147081 NA 1.18 12.3 0.6 8.08e-28 Diabetic kidney disease; CESC cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg11752832 chr7:134001865 SLC35B4 0.57 7.47 0.42 1.2e-12 Mean platelet volume; CESC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg08859206 chr1:53392774 SCP2 0.54 6.79 0.38 7.33e-11 Monocyte count; CESC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg26818010 chr10:134567672 INPP5A -0.9 -11.14 -0.56 6.82e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs546131 0.820 rs744841 chr11:34857667 G/A cg06937548 chr11:34938143 PDHX;APIP 0.49 6.22 0.36 1.97e-9 Lung disease severity in cystic fibrosis; CESC cis rs703842 0.616 rs870392 chr12:58219173 C/A cg04478727 chr12:58166393 METTL1;FAM119B 0.56 6.46 0.37 5e-10 Multiple sclerosis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg26526983 chr16:12136938 RUNDC2A 0.42 6.0 0.35 6.45e-9 Fibrinogen levels; CESC cis rs9611565 0.694 rs2142505 chr22:41820541 A/G cg06634786 chr22:41940651 POLR3H 0.73 7.31 0.41 3.18e-12 Vitiligo; CESC cis rs12325245 0.536 rs12709002 chr16:58614337 A/C cg02549819 chr16:58548995 SETD6 0.97 6.45 0.37 5.42e-10 Schizophrenia; CESC cis rs7208859 0.562 rs11650923 chr17:29008167 G/A cg19761014 chr17:28927070 LRRC37B2 0.82 6.69 0.38 1.3100000000000001e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02079880 chr6:157802436 ZDHHC14 0.59 6.21 0.36 2e-9 Gut microbiome composition (summer); CESC cis rs7674212 0.540 rs2720469 chr4:104086484 C/T cg16532752 chr4:104119610 CENPE -0.44 -5.96 -0.34 8.1e-9 Type 2 diabetes; CESC cis rs2742417 0.609 rs11709306 chr3:45773732 G/A cg04837898 chr3:45731254 SACM1L -0.46 -6.11 -0.35 3.5e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs15676 0.812 rs10819447 chr9:131576416 T/G cg00228799 chr9:131580591 ENDOG 0.44 5.44 0.32 1.21e-7 Blood metabolite levels; CESC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg18758796 chr5:131593413 PDLIM4 0.38 5.11 0.3 6.09e-7 Blood metabolite levels; CESC cis rs113835537 0.529 rs57207756 chr11:66270360 C/T cg24851651 chr11:66362959 CCS 0.48 5.7 0.33 3.11e-8 Airway imaging phenotypes; CESC cis rs3747547 0.892 rs11792678 chr9:38020036 A/G cg13774184 chr9:37916125 SHB -0.73 -6.25 -0.36 1.61e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg17766062 chr2:75062663 HK2 0.51 6.47 0.37 4.7e-10 Gut microbiota (bacterial taxa); CESC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg00310523 chr12:86230176 RASSF9 0.35 5.4 0.31 1.47e-7 Major depressive disorder; CESC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg22143856 chr6:28129313 ZNF389 0.49 6.3 0.36 1.2e-9 Depression; CESC trans rs877282 0.838 rs11253373 chr10:774857 A/G cg22713356 chr15:30763199 NA 1.24 12.53 0.61 1.32e-28 Uric acid levels; CESC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.71e-30 Developmental language disorder (linguistic errors); CESC trans rs877282 0.891 rs11595385 chr10:800539 A/G cg22713356 chr15:30763199 NA 1.36 13.59 0.64 2.89e-32 Uric acid levels; CESC cis rs72634258 0.786 rs6682709 chr1:8173796 A/C cg00042356 chr1:8021962 PARK7 -0.47 -5.21 -0.3 3.76e-7 Inflammatory bowel disease; CESC cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg27347728 chr4:17578864 LAP3 0.49 5.58 0.32 6.07e-8 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs3820928 0.874 rs10166736 chr2:227900419 C/T cg11843606 chr2:227700838 RHBDD1 -0.5 -6.51 -0.37 3.73e-10 Pulmonary function; CESC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg05315796 chr3:52349193 DNAH1 0.3 5.24 0.31 3.23e-7 Electroencephalogram traits; CESC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg27266027 chr21:40555129 PSMG1 0.44 5.21 0.3 3.77e-7 Cognitive function; CESC cis rs5750830 0.620 rs1007337 chr22:39781585 C/T cg05872129 chr22:39784769 NA -0.77 -11.03 -0.56 1.59e-23 Intelligence (multi-trait analysis); CESC cis rs12348691 0.503 rs7849834 chr9:100606188 T/C cg13688889 chr9:100608707 NA -0.89 -13.48 -0.64 7.1e-32 Alopecia areata; CESC cis rs1065852 0.526 rs56234624 chr22:42388826 A/G cg22189786 chr22:42395067 WBP2NL 0.43 5.42 0.32 1.33e-7 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CESC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg21782813 chr7:2030301 MAD1L1 0.5 7.18 0.4 6.92e-12 Bipolar disorder and schizophrenia; CESC cis rs6433857 0.657 rs2368177 chr2:181501242 T/C cg23363182 chr2:181467187 NA -0.45 -6.8 -0.39 6.88e-11 Body mass index; CESC cis rs3105593 1.000 rs3101855 chr15:50859874 A/G cg08437265 chr15:50716283 USP8 0.4 5.19 0.3 4.28e-7 QT interval; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10334916 chr2:241508098 RNPEPL1 0.54 6.13 0.35 3.18e-9 Gut microbiome composition (summer); CESC cis rs9818941 0.824 rs4511848 chr3:157732021 A/C cg08654915 chr3:157813417 NA -0.45 -7.28 -0.41 3.9e-12 Height; CESC trans rs6462411 0.652 rs12701229 chr7:3896634 A/G cg08023175 chr19:57967606 VN1R1 -0.41 -6.06 -0.35 4.72e-9 Quantitative traits; CESC cis rs7824557 0.583 rs4448232 chr8:11231354 G/T cg21775007 chr8:11205619 TDH 0.55 8.3 0.45 5.24e-15 Retinal vascular caliber; CESC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 7.46 0.42 1.24e-12 Tonsillectomy; CESC cis rs9611565 0.512 rs139573 chr22:42214785 G/A cg06481639 chr22:41940642 POLR3H -0.57 -5.59 -0.32 5.59e-8 Vitiligo; CESC cis rs7208859 0.673 rs999796 chr17:29159404 G/C cg19761014 chr17:28927070 LRRC37B2 0.56 5.54 0.32 7.17e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs501120 0.810 rs510785 chr10:44749990 C/A cg09554077 chr10:44749378 NA 0.51 6.82 0.39 6.06e-11 Coronary artery disease;Coronary heart disease; CESC cis rs950776 0.720 rs11637890 chr15:78935419 C/G cg06917634 chr15:78832804 PSMA4 -0.54 -6.49 -0.37 4.31e-10 Sudden cardiac arrest; CESC cis rs11155671 0.530 rs9383914 chr6:150207234 T/G cg09699651 chr6:150184138 LRP11 0.55 7.61 0.42 4.89e-13 Testicular germ cell tumor; CESC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg22823121 chr1:150693482 HORMAD1 0.48 6.65 0.38 1.63e-10 Melanoma; CESC cis rs10744422 1.000 rs2135014 chr12:123333065 C/T cg25930673 chr12:123319894 HIP1R -0.72 -5.73 -0.33 2.79e-8 Schizophrenia; CESC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg17376030 chr22:41985996 PMM1 0.68 7.17 0.4 7.37e-12 Vitiligo; CESC cis rs965469 1.000 rs6051792 chr20:3343519 T/C cg25506879 chr20:3388711 C20orf194 -0.55 -5.85 -0.34 1.43e-8 IFN-related cytopenia; CESC cis rs7666738 0.606 rs10006454 chr4:99080361 G/A cg24818145 chr4:99064322 C4orf37 0.4 5.14 0.3 5.32e-7 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg11494091 chr17:61959527 GH2 0.72 12.33 0.6 6.37e-28 Prudent dietary pattern; CESC cis rs12118280 0.512 rs116395849 chr1:108750548 G/A cg11967332 chr1:108735228 SLC25A24 0.64 6.79 0.38 7.34e-11 Myeloid white cell count; CESC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg02569458 chr12:86230093 RASSF9 -0.46 -7.15 -0.4 8.28e-12 Major depressive disorder; CESC cis rs7267979 1.000 rs7020 chr20:25278600 G/A cg08601574 chr20:25228251 PYGB 0.38 5.51 0.32 8.32e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs1983170 0.673 rs11164934 chr1:92015267 C/T cg02896835 chr1:92012615 NA 0.55 5.38 0.31 1.61e-7 Eosinophil percentage of white cells; CESC cis rs7818688 0.546 rs13250762 chr8:95987570 A/G cg16049864 chr8:95962084 TP53INP1 0.55 5.82 0.34 1.67e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs7917772 0.636 rs4919676 chr10:104524352 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -5.18 -0.3 4.3e-7 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2204008 0.744 rs67889662 chr12:38327042 T/A cg26384229 chr12:38710491 ALG10B 0.74 10.63 0.55 3.17e-22 Bladder cancer; CESC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg13206674 chr6:150067644 NUP43 0.42 5.83 0.34 1.64e-8 Lung cancer; CESC cis rs7584330 0.737 rs61212490 chr2:238365230 T/C cg14458575 chr2:238380390 NA 0.62 8.39 0.46 3.03e-15 Prostate cancer; CESC cis rs6121246 0.529 rs6060174 chr20:30183538 G/A cg13852791 chr20:30311386 BCL2L1 0.58 5.51 0.32 8.44e-8 Mean corpuscular hemoglobin; CESC cis rs6754311 0.731 rs4954490 chr2:136608231 G/A cg15123519 chr2:136567270 LCT 0.31 5.16 0.3 4.81e-7 Mosquito bite size; CESC cis rs11792861 0.541 rs838824 chr9:111670707 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.42 -5.6 -0.33 5.3e-8 Menarche (age at onset); CESC cis rs7697216 0.668 rs4072805 chr4:175839285 C/G cg14561282 chr4:175839468 ADAM29 0.5 5.52 0.32 8.07e-8 Breast cancer; CESC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg18252515 chr7:66147081 NA 0.46 6.0 0.35 6.54e-9 Aortic root size; CESC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg24399712 chr22:39784796 NA -0.83 -11.13 -0.56 7.06e-24 Intelligence (multi-trait analysis); CESC cis rs9486719 0.948 rs2499813 chr6:96875338 T/C cg06623918 chr6:96969491 KIAA0776 0.81 8.23 0.45 8.62e-15 Migraine;Coronary artery disease; CESC cis rs11112613 0.713 rs12296355 chr12:105953321 C/A cg03607813 chr12:105948248 NA 0.59 7.23 0.41 5.26e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CESC cis rs7264396 0.563 rs6060570 chr20:34291166 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.64 6.86 0.39 4.8e-11 Total cholesterol levels; CESC cis rs8114671 0.836 rs6058154 chr20:33585834 C/T cg08999081 chr20:33150536 PIGU -0.36 -5.08 -0.3 7.13e-7 Height; CESC cis rs714031 0.900 rs5757762 chr22:40064581 C/T cg21377881 chr22:40064566 CACNA1I -0.41 -6.67 -0.38 1.5e-10 Schizophrenia; CESC trans rs7395662 0.517 rs10454483 chr11:48754997 A/G cg15704280 chr7:45808275 SEPT13 -0.58 -7.01 -0.4 1.94e-11 HDL cholesterol; CESC cis rs8020095 0.571 rs1918483 chr14:67607623 G/T cg19548862 chr14:67692701 FAM71D -0.47 -5.58 -0.32 5.87e-8 Depression (quantitative trait); CESC cis rs858239 0.665 rs6964665 chr7:23211352 G/A cg23682824 chr7:23144976 KLHL7 0.46 6.03 0.35 5.5e-9 Cerebrospinal fluid biomarker levels; CESC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg11905131 chr22:24372483 LOC391322 -0.64 -9.33 -0.5 4.35e-18 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs10885582 0.754 rs10885576 chr10:116298843 G/A cg17056676 chr10:116301354 ABLIM1 -0.29 -5.3 -0.31 2.38e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs477692 0.905 rs555545 chr10:131411586 G/A cg05714579 chr10:131428358 MGMT 0.52 7.3 0.41 3.29e-12 Response to temozolomide; CESC cis rs7680126 0.597 rs78917351 chr4:10208063 A/C cg00071950 chr4:10020882 SLC2A9 -0.53 -5.88 -0.34 1.2e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CESC cis rs6740322 0.948 rs6715072 chr2:43562230 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.57 -6.37 -0.36 8.27e-10 Coronary artery disease; CESC trans rs1373453 0.764 rs710729 chr12:70061392 A/G cg19702771 chr4:82058885 PRKG2 0.65 6.02 0.35 5.66e-9 Orofacial clefts; CESC cis rs763121 1.000 rs138457 chr22:38898051 T/C cg06544989 chr22:39130855 UNC84B -0.43 -7.71 -0.43 2.5e-13 Menopause (age at onset); CESC cis rs3820928 0.648 rs1997484 chr2:227898962 T/A cg11843606 chr2:227700838 RHBDD1 -0.48 -6.44 -0.37 5.72e-10 Pulmonary function; CESC cis rs73195822 0.667 rs7967408 chr12:111164408 A/C cg12870014 chr12:110450643 ANKRD13A 0.64 5.66 0.33 3.91e-8 Itch intensity from mosquito bite; CESC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg18252515 chr7:66147081 NA -0.46 -6.05 -0.35 5e-9 Aortic root size; CESC cis rs7605827 0.930 rs7571679 chr2:15596603 C/T cg19274914 chr2:15703543 NA 0.32 5.69 0.33 3.38e-8 Educational attainment (years of education); CESC cis rs9309473 0.607 rs7567343 chr2:73596605 C/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.79 -0.39 7.27e-11 Metabolite levels; CESC cis rs992157 0.798 rs10193383 chr2:219157692 C/T cg00012203 chr2:219082015 ARPC2 0.75 9.7 0.51 3.1e-19 Colorectal cancer; CESC cis rs1707322 0.717 rs2991989 chr1:46082965 C/T cg03146154 chr1:46216737 IPP -0.8 -11.01 -0.56 1.87e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs72781680 0.611 rs4149373 chr2:24300023 C/T cg08917208 chr2:24149416 ATAD2B 0.54 5.15 0.3 5.09e-7 Lymphocyte counts; CESC cis rs7208859 0.623 rs9899268 chr17:29150255 T/C cg14008862 chr17:28927542 LRRC37B2 0.66 5.22 0.31 3.64e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs8180040 0.729 rs11720439 chr3:47347003 T/G cg27129171 chr3:47204927 SETD2 -0.63 -9.12 -0.49 1.97e-17 Colorectal cancer; CESC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg16405210 chr4:1374714 KIAA1530 0.94 12.7 0.62 3.5e-29 Longevity; CESC cis rs7923609 0.967 rs10509189 chr10:65264126 T/C cg01631684 chr10:65280961 REEP3 -0.43 -5.4 -0.31 1.47e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs7188697 0.845 rs1981960 chr16:58597289 C/G cg02549819 chr16:58548995 SETD6 0.43 5.4 0.31 1.51e-7 QT interval; CESC cis rs6570726 0.526 rs4895674 chr6:145735860 T/G cg23711669 chr6:146136114 FBXO30 -0.55 -7.1 -0.4 1.13e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7520050 0.966 rs11579634 chr1:46466391 A/G cg03146154 chr1:46216737 IPP 0.41 5.13 0.3 5.73e-7 Red blood cell count;Reticulocyte count; CESC cis rs9926296 0.632 rs72807526 chr16:89775946 A/G cg03605463 chr16:89740564 NA 0.55 6.57 0.37 2.73e-10 Vitiligo; CESC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg26304593 chr6:42947056 PEX6 -0.43 -5.55 -0.32 6.8e-8 Alzheimer's disease in APOE e4+ carriers; CESC cis rs950169 0.919 rs17300292 chr15:84762568 G/C cg17507749 chr15:85114479 UBE2QP1 0.61 6.73 0.38 1.05e-10 Schizophrenia; CESC cis rs34375054 0.660 rs57031290 chr12:125593053 A/G cg25124228 chr12:125621409 AACS -0.56 -6.63 -0.38 1.84e-10 Post bronchodilator FEV1/FVC ratio; CESC trans rs60380162 0.963 rs4655942 chr1:87722759 G/T cg20163645 chr8:1900353 ARHGEF10 -0.43 -6.05 -0.35 4.95e-9 Loneliness (linear analysis); CESC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg08499158 chr17:42289980 UBTF 0.52 6.51 0.37 3.65e-10 Total body bone mineral density; CESC cis rs6912958 1.000 rs6933587 chr6:88175577 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.53 -7.42 -0.41 1.56e-12 Monocyte percentage of white cells; CESC cis rs2204008 0.744 rs11514073 chr12:38399553 A/C cg26384229 chr12:38710491 ALG10B 0.73 10.39 0.54 1.89e-21 Bladder cancer; CESC cis rs2228479 0.850 rs11649162 chr16:89807131 C/A cg14709524 chr16:89940631 TCF25 0.92 6.91 0.39 3.59e-11 Skin colour saturation; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21518056 chr19:33183187 NUDT19 0.62 6.81 0.39 6.7e-11 Gut microbiome composition (summer); CESC cis rs67311347 1.000 rs73080137 chr3:40516412 A/G cg24209194 chr3:40518798 ZNF619 0.53 6.99 0.39 2.23e-11 Renal cell carcinoma; CESC cis rs9303401 0.573 rs62081879 chr17:57181524 C/T cg02118635 chr17:56770003 RAD51C;TEX14 1.0 12.81 0.62 1.44e-29 Cognitive test performance; CESC cis rs9549260 0.567 rs7332730 chr13:41265979 C/A cg21288729 chr13:41239152 FOXO1 0.61 7.72 0.43 2.43e-13 Red blood cell count; CESC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.64 -0.51 4.83e-19 Alzheimer's disease; CESC cis rs11077998 0.967 rs11657886 chr17:80516173 T/C cg10255544 chr17:80519551 FOXK2 0.54 8.71 0.47 3.3e-16 Reticulocyte fraction of red cells; CESC cis rs4523957 0.614 rs7220685 chr17:2059385 A/G cg16513277 chr17:2031491 SMG6 -0.72 -10.2 -0.53 8.12e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg03684893 chr10:554711 DIP2C 0.39 5.94 0.34 9.14e-9 Psychosis in Alzheimer's disease; CESC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg23281280 chr6:28129359 ZNF389 0.42 6.22 0.36 1.92e-9 Parkinson's disease; CESC trans rs61931739 0.500 rs7306435 chr12:34482933 A/G cg13010199 chr12:38710504 ALG10B -0.5 -6.41 -0.37 6.7e-10 Morning vs. evening chronotype; CESC cis rs8014204 0.935 rs2853779 chr14:75368508 G/A cg26191576 chr14:75389716 RPS6KL1 0.36 5.25 0.31 3.06e-7 Caffeine consumption; CESC cis rs6942756 1.000 rs9640854 chr7:128884057 A/T cg02491457 chr7:128862824 NA -0.67 -9.4 -0.5 2.77e-18 White matter hyperintensity burden; CESC cis rs7607369 0.559 rs4674343 chr2:219660346 C/T cg02176678 chr2:219576539 TTLL4 0.39 6.96 0.39 2.68e-11 Red blood cell count;Amyotrophic lateral sclerosis; CESC cis rs79976124 0.879 rs10944856 chr6:66636960 G/C cg07460842 chr6:66804631 NA 0.72 8.31 0.45 5.13e-15 Type 2 diabetes; CESC cis rs7834588 0.523 rs4134468 chr8:63841096 T/C cg20602954 chr8:63776762 NKAIN3 0.32 5.31 0.31 2.27e-7 Response to Vitamin E supplementation; CESC cis rs1949733 1.000 rs1880023 chr4:8480831 C/T cg11789530 chr4:8429930 ACOX3 -0.78 -11.27 -0.57 2.5e-24 Response to antineoplastic agents; CESC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg19346786 chr7:2764209 NA -0.47 -6.8 -0.39 6.74e-11 Height; CESC cis rs9911578 1.000 rs3744109 chr17:56594197 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -5.53 -0.32 7.63e-8 Intelligence (multi-trait analysis); CESC cis rs11785400 1.000 rs9720653 chr8:143731939 T/G cg24634471 chr8:143751801 JRK 0.46 6.03 0.35 5.46e-9 Schizophrenia; CESC cis rs2302190 0.882 rs11658998 chr17:56655786 T/G cg25885038 chr17:56607967 SEPT4 -0.4 -5.43 -0.32 1.27e-7 Vitamin D levels; CESC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg05564831 chr3:52568323 NT5DC2 0.48 7.64 0.42 4.06e-13 Bipolar disorder; CESC cis rs7312933 0.618 rs6582390 chr12:42634586 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 5.96 0.34 8e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CESC cis rs2735413 0.514 rs7192129 chr16:78136414 A/G cg04733911 chr16:78082701 NA 0.38 6.09 0.35 3.99e-9 Systolic blood pressure (alcohol consumption interaction); CESC cis rs4523957 0.893 rs11078019 chr17:2162121 G/A cg16513277 chr17:2031491 SMG6 -0.6 -8.18 -0.45 1.22e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs4819052 0.788 rs13049700 chr21:46701909 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 12.16 0.6 2.4e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CESC cis rs8017423 0.935 rs4904661 chr14:90729332 T/C cg14092571 chr14:90743983 NA -0.56 -8.38 -0.46 3.07e-15 Mortality in heart failure; CESC cis rs2479106 0.553 rs3739827 chr9:126690157 A/G cg16191174 chr9:126692580 DENND1A -0.52 -6.45 -0.37 5.37e-10 Polycystic ovary syndrome; CESC cis rs7259376 0.936 rs10454118 chr19:22559605 C/G cg02657401 chr19:22469223 NA 0.25 5.07 0.3 7.45e-7 Menopause (age at onset); CESC cis rs2742234 0.955 rs2503865 chr10:43659536 C/T cg07801480 chr10:43725741 RASGEF1A 0.42 5.99 0.35 6.69e-9 Hirschsprung disease; CESC cis rs4835473 0.932 rs6847869 chr4:144904034 C/A cg25736465 chr4:144833511 NA 0.4 6.13 0.35 3.25e-9 Immature fraction of reticulocytes; CESC cis rs9291683 0.588 rs3796829 chr4:10019138 C/G cg11266682 chr4:10021025 SLC2A9 0.72 14.87 0.67 8.73e-37 Bone mineral density; CESC cis rs7512552 0.839 rs832622 chr1:150392830 A/G cg15654264 chr1:150340011 RPRD2 0.4 5.3 0.31 2.4e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC cis rs2415984 0.538 rs4595715 chr14:46967541 C/T cg14871534 chr14:47121158 RPL10L -0.34 -5.07 -0.3 7.31e-7 Number of children ever born; CESC cis rs7772486 0.875 rs11755334 chr6:146399297 T/C cg23711669 chr6:146136114 FBXO30 0.82 12.45 0.61 2.54e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs672059 1.000 rs638781 chr1:183157358 T/G ch.1.3577855R chr1:183094577 LAMC1 0.54 6.99 0.39 2.28e-11 Hypertriglyceridemia; CESC cis rs7799006 0.606 rs878534 chr7:2314652 G/A cg12745145 chr7:2261452 MAD1L1 -0.33 -5.19 -0.3 4.18e-7 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg17376030 chr22:41985996 PMM1 -0.55 -6.21 -0.36 1.98e-9 Vitiligo; CESC cis rs1707322 0.752 rs11211168 chr1:46163647 C/T cg03146154 chr1:46216737 IPP 0.82 11.55 0.58 2.81e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg11239016 chr16:90085722 DBNDD1 0.58 6.46 0.37 5.05e-10 Gut microbiome composition (summer); CESC cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.38 -6.41 -0.37 6.46e-10 Hemoglobin concentration; CESC cis rs561341 1.000 rs548957 chr17:30302411 G/A cg23018236 chr17:30244563 NA -0.52 -5.1 -0.3 6.39e-7 Hip circumference adjusted for BMI; CESC cis rs7927771 0.832 rs7940536 chr11:47395240 G/A cg20307385 chr11:47447363 PSMC3 0.59 7.03 0.4 1.73e-11 Subjective well-being; CESC cis rs11677416 1.000 rs4848300 chr2:113527906 T/C cg27083787 chr2:113543245 IL1A 0.41 5.16 0.3 4.75e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg17541715 chr7:1216824 NA -0.4 -5.59 -0.32 5.68e-8 Longevity;Endometriosis; CESC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg23985595 chr17:80112537 CCDC57 -0.41 -6.46 -0.37 4.88e-10 Life satisfaction; CESC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg04414720 chr1:150670196 GOLPH3L 0.63 9.01 0.48 4.11e-17 Tonsillectomy; CESC cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg00255919 chr5:131827918 IRF1 0.53 8.28 0.45 6.28e-15 Asthma (sex interaction); CESC cis rs793571 0.544 rs383902 chr15:59034174 C/T cg05156742 chr15:59063176 FAM63B 0.65 8.83 0.48 1.44e-16 Schizophrenia; CESC cis rs7692995 1.000 rs1380293 chr4:18027235 T/C cg08925142 chr4:18023851 LCORL -0.44 -5.14 -0.3 5.22e-7 Height; CESC cis rs754466 0.580 rs10762765 chr10:79566407 T/C cg17075019 chr10:79541650 NA -0.82 -12.76 -0.62 2.19e-29 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg03425468 chr1:155164676 MIR92B -0.44 -6.35 -0.36 9.48e-10 Fibrinogen levels; CESC cis rs12545109 0.879 rs893234 chr8:57363885 G/A cg09654669 chr8:57350985 NA -0.57 -6.65 -0.38 1.66e-10 Obesity-related traits; CESC cis rs34779708 0.931 rs72789687 chr10:35372489 G/A cg03585969 chr10:35415529 CREM 0.77 10.07 0.53 2.06e-20 Inflammatory bowel disease;Crohn's disease; CESC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.18 0.3 4.37e-7 Bipolar disorder; CESC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg20203395 chr5:56204925 C5orf35 -0.39 -5.24 -0.31 3.23e-7 Initial pursuit acceleration; CESC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg07090678 chr1:91966139 CDC7 0.42 5.67 0.33 3.66e-8 Breast cancer; CESC cis rs1801251 0.778 rs2250654 chr2:233752376 A/T cg25237894 chr2:233734115 C2orf82 -0.5 -8.87 -0.48 1.14e-16 Coronary artery disease; CESC cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg17366294 chr4:99064904 C4orf37 0.57 7.94 0.44 5.7e-14 Colonoscopy-negative controls vs population controls; CESC cis rs795484 0.610 rs2936839 chr12:118580315 T/C cg16572268 chr12:118583242 PEBP1 -0.35 -5.06 -0.3 8.02e-7 Morphine dose requirement in tonsillectomy and adenoidectomy surgery; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09551160 chr10:80828924 ZMIZ1 0.53 6.2 0.36 2.18e-9 Gut microbiome composition (summer); CESC cis rs2742417 0.603 rs2064063 chr3:45759924 T/A cg04837898 chr3:45731254 SACM1L -0.47 -6.25 -0.36 1.61e-9 Response to anti-depressant treatment in major depressive disorder; CESC cis rs55823223 0.648 rs936394 chr17:73852008 C/A cg10935138 chr17:73851978 WBP2 0.84 9.68 0.51 3.62e-19 Psoriasis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12277888 chr11:35723985 TRIM44 -0.65 -7.82 -0.43 1.29e-13 Gut microbiome composition (summer); CESC cis rs9640161 0.789 rs2098053 chr7:150043205 G/A cg17279839 chr7:150038598 RARRES2 0.51 6.03 0.35 5.62e-9 Blood protein levels;Circulating chemerin levels; CESC cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg22875332 chr1:76189707 ACADM 0.66 7.81 0.43 1.31e-13 Blood metabolite levels;Acylcarnitine levels; CESC cis rs11249608 0.636 rs62393070 chr5:178447943 A/G cg21905437 chr5:178450457 ZNF879 0.58 8.09 0.45 2.14e-14 Pubertal anthropometrics; CESC trans rs3780486 0.813 rs3780488 chr9:33133812 T/C cg04842962 chr6:43655489 MRPS18A 1.0 18.73 0.75 1.91e-50 IgG glycosylation; CESC cis rs7264396 1.000 rs224429 chr20:34152018 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.54 -7.01 -0.4 2.04e-11 Total cholesterol levels; CESC cis rs17666538 0.792 rs7820788 chr8:601846 C/T cg23958373 chr8:599963 NA 0.78 6.22 0.36 1.93e-9 IgG glycosylation; CESC cis rs7666738 0.830 rs13147768 chr4:98833675 A/T cg05340658 chr4:99064831 C4orf37 0.72 10.37 0.54 2.25e-21 Colonoscopy-negative controls vs population controls; CESC cis rs6547741 0.967 rs4665996 chr2:27814343 T/C cg21248554 chr2:27665150 KRTCAP3 0.25 5.08 0.3 7.23e-7 Oral cavity cancer; CESC cis rs2635047 0.615 rs2684819 chr18:44710691 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 5.59 0.32 5.7e-8 Educational attainment; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg16579101 chr12:6677158 NOP2 0.48 6.55 0.37 2.94e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs2295359 1.000 rs11465753 chr1:67631423 T/C cg03340356 chr1:67600835 NA 0.33 5.34 0.31 2e-7 Psoriasis; CESC cis rs8053891 0.615 rs2000999 chr16:72108093 G/A cg01557791 chr16:72042693 DHODH -0.49 -5.05 -0.3 8.32e-7 Coronary artery disease; CESC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg27121462 chr16:89883253 FANCA 0.77 11.41 0.57 8.45e-25 Vitiligo; CESC cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg05639522 chr1:247681581 NA 0.45 6.05 0.35 4.97e-9 Acute lymphoblastic leukemia (childhood); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08030545 chr16:22308466 POLR3E -0.66 -8.08 -0.44 2.37e-14 Gut microbiome composition (summer); CESC cis rs1577917 1.000 rs10498958 chr6:86649705 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.51 6.65 0.38 1.62e-10 Response to antipsychotic treatment; CESC cis rs9512730 0.553 rs1007701 chr13:28049143 C/G cg04070771 chr13:27998621 GTF3A -0.49 -5.41 -0.32 1.4e-7 Schizophrenia; CESC cis rs11997175 0.646 rs10954936 chr8:33686165 C/T ch.8.33884649F chr8:33765107 NA 0.57 7.37 0.41 2.15e-12 Body mass index; CESC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg16743903 chr16:89593216 SPG7 -0.39 -5.07 -0.3 7.45e-7 Multiple myeloma (IgH translocation); CESC cis rs2742234 0.911 rs3004214 chr10:43631698 C/T cg15436174 chr10:43711423 RASGEF1A -0.43 -5.16 -0.3 4.88e-7 Hirschsprung disease; CESC trans rs208520 0.909 rs60604603 chr6:67022955 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.81 7.68 0.43 3.1400000000000003e-13 Exhaled nitric oxide output; CESC cis rs11677416 1.000 rs72825514 chr2:113527706 G/T cg27083787 chr2:113543245 IL1A 0.58 7.33 0.41 2.81e-12 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs9788682 1.000 rs9788682 chr15:78802586 A/G cg06917634 chr15:78832804 PSMA4 0.48 5.58 0.32 6.07e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CESC cis rs7512552 0.839 rs7523428 chr1:150430472 G/A cg15654264 chr1:150340011 RPRD2 0.39 5.19 0.3 4.1e-7 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CESC trans rs208515 0.560 rs207084 chr6:66776966 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -19.26 -0.76 2.71e-52 Exhaled nitric oxide levels; CESC cis rs7923609 0.846 rs10761739 chr10:65062008 C/G cg01631684 chr10:65280961 REEP3 0.44 5.53 0.32 7.61e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs3820068 0.608 rs12740492 chr1:16048951 A/T cg13390004 chr1:15929781 NA 0.33 5.05 0.3 8.14e-7 Systolic blood pressure; CESC cis rs59072704 0.920 rs74373761 chr1:244496553 G/C cg16908123 chr1:244486252 NA -0.47 -5.42 -0.32 1.32e-7 Monocyte count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19585003 chr12:112280177 C12orf47;MAPKAPK5 0.58 6.34 0.36 9.73e-10 Gut microbiome composition (summer); CESC cis rs2479106 0.656 rs1857393 chr9:126497262 T/C cg16191174 chr9:126692580 DENND1A 0.42 5.17 0.3 4.59e-7 Polycystic ovary syndrome; CESC cis rs8018808 0.967 rs12889722 chr14:77850267 T/C cg20045696 chr14:77926864 AHSA1 -0.37 -5.06 -0.3 7.85e-7 Myeloid white cell count; CESC cis rs7772486 0.840 rs2777478 chr6:146309117 T/C cg23711669 chr6:146136114 FBXO30 0.9 13.1 0.63 1.45e-30 Lobe attachment (rater-scored or self-reported); CESC cis rs6933660 0.646 rs6915598 chr6:151778664 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.57 5.74 0.33 2.53e-8 Menarche (age at onset); CESC cis rs8111998 0.826 rs10421335 chr19:22768105 G/A cg19914732 chr19:22715077 NA -0.37 -5.18 -0.3 4.45e-7 Corneal structure; CESC cis rs17253792 0.822 rs79807559 chr14:56108117 G/A cg01858014 chr14:56050164 KTN1 -0.96 -7.52 -0.42 8.3e-13 Putamen volume; CESC trans rs4756846 1.000 rs72871370 chr11:16440171 T/A cg05579622 chr5:10618622 ANKRD33B 0.75 6.83 0.39 5.71e-11 Obesity and osteoporosis; CESC cis rs7605827 0.930 rs2277915 chr2:15493881 A/G cg19274914 chr2:15703543 NA 0.31 5.62 0.33 4.89e-8 Educational attainment (years of education); CESC cis rs9858542 1.000 rs9882740 chr3:49702484 T/C cg07274523 chr3:49395745 GPX1 0.65 8.36 0.46 3.6e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC trans rs11148252 0.595 rs4885117 chr13:53153027 T/C cg18335740 chr13:41363409 SLC25A15 0.57 7.98 0.44 4.48e-14 Lewy body disease; CESC cis rs977987 0.872 rs4887816 chr16:75319716 T/C cg03315344 chr16:75512273 CHST6 0.4 5.59 0.32 5.76e-8 Dupuytren's disease; CESC cis rs35110281 0.693 rs3819161 chr21:45092653 A/G cg04455712 chr21:45112962 RRP1B 0.49 7.14 0.4 9.24e-12 Mean corpuscular volume; CESC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg19622623 chr12:86230825 RASSF9 0.48 6.4 0.37 6.89e-10 Major depressive disorder; CESC cis rs3026101 0.671 rs1806265 chr17:5320044 T/A cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.8 0.34 1.87e-8 Body mass index; CESC cis rs2011503 0.941 rs2010506 chr19:19387356 C/T cg11584989 chr19:19387371 SF4 0.62 7.43 0.42 1.48e-12 Bipolar disorder; CESC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg07870213 chr5:140052090 DND1 0.65 6.78 0.38 7.75e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs5769765 1.000 rs34774661 chr22:50267508 C/G cg26441486 chr22:50317300 CRELD2 -0.39 -5.5 -0.32 8.72e-8 Schizophrenia; CESC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg27535305 chr1:53392650 SCP2 0.31 5.51 0.32 8.35e-8 Monocyte count; CESC cis rs9303280 0.743 rs12946510 chr17:37912377 C/T cg19468946 chr17:37922297 IKZF3 -0.42 -5.73 -0.33 2.73e-8 Self-reported allergy; CESC cis rs1448094 0.845 rs7132262 chr12:86346304 C/T cg02569458 chr12:86230093 RASSF9 0.39 5.64 0.33 4.25e-8 Major depressive disorder; CESC cis rs796364 0.806 rs56216998 chr2:200944333 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.77 -6.8 -0.39 6.95e-11 Schizophrenia; CESC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg23758822 chr17:41437982 NA 0.99 16.77 0.72 1.6700000000000001e-43 Menopause (age at onset); CESC cis rs9902453 0.817 rs7217961 chr17:28403112 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -9.08 -0.49 2.59e-17 Coffee consumption (cups per day); CESC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg04234412 chr22:24373322 LOC391322 -0.56 -7.02 -0.4 1.84e-11 Urinary 1,3-butadiene metabolite levels in smokers; CESC cis rs12618769 0.597 rs961242 chr2:99138979 G/A cg10123293 chr2:99228465 UNC50 0.4 5.38 0.31 1.64e-7 Bipolar disorder; CESC trans rs1116547 0.602 rs4705551 chr5:112843077 C/G cg10115368 chr14:100435663 NA 0.51 6.05 0.35 4.85e-9 Cerebral amyloid angiopathy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg26310643 chr1:87019145 CLCA4 -0.53 -6.0 -0.35 6.6e-9 Gut microbiome composition (summer); CESC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg04267008 chr7:1944627 MAD1L1 -0.61 -7.4 -0.41 1.77e-12 Bipolar disorder and schizophrenia; CESC cis rs1801251 0.896 rs921054 chr2:233694673 G/A cg25237894 chr2:233734115 C2orf82 -0.36 -6.47 -0.37 4.65e-10 Coronary artery disease; CESC cis rs7666738 0.830 rs11944855 chr4:99068258 G/A cg03467027 chr4:99064603 C4orf37 0.48 5.96 0.34 7.81e-9 Colonoscopy-negative controls vs population controls; CESC cis rs9916302 0.904 rs2061338 chr17:37421767 T/C cg07936489 chr17:37558343 FBXL20 -0.8 -11.48 -0.58 5.11e-25 Glomerular filtration rate (creatinine); CESC cis rs10097731 0.901 rs10464891 chr8:82042900 C/A cg25230327 chr8:82042993 NA -0.56 -6.33 -0.36 1.06e-9 Serum total protein level; CESC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg23982607 chr1:1823379 GNB1 -0.79 -12.85 -0.62 1.04e-29 Body mass index; CESC cis rs8114671 0.805 rs4616 chr20:33590358 C/T cg07148914 chr20:33460835 GGT7 -0.43 -5.53 -0.32 7.53e-8 Height; CESC cis rs6430585 0.583 rs2322813 chr2:136582809 A/G cg07169764 chr2:136633963 MCM6 1.35 20.2 0.78 1.47e-55 Corneal structure; CESC cis rs17023223 0.537 rs4508058 chr1:119684250 T/C cg05756136 chr1:119680316 WARS2 -0.46 -5.54 -0.32 7.2e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CESC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg24733560 chr20:60626293 TAF4 0.45 6.44 0.37 5.45e-10 Body mass index; CESC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.99 11.37 0.57 1.18e-24 Platelet count; CESC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg21248554 chr2:27665150 KRTCAP3 -0.29 -6.2 -0.36 2.17e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg24503407 chr1:205819492 PM20D1 0.84 13.9 0.65 2.34e-33 Menarche (age at onset); CESC cis rs473651 0.716 rs548179 chr2:239320505 G/A cg21699342 chr2:239360505 ASB1 0.5 8.24 0.45 8.13e-15 Multiple system atrophy; CESC trans rs11039798 0.660 rs28435129 chr11:48629795 A/T cg15704280 chr7:45808275 SEPT13 0.6 6.24 0.36 1.73e-9 Axial length; CESC cis rs10465746 0.780 rs7551787 chr1:84419297 A/G cg10977910 chr1:84465055 TTLL7 0.51 7.22 0.41 5.54e-12 Obesity-related traits; CESC cis rs11825685 0.887 rs76377465 chr11:134569562 T/G cg06603561 chr11:134479413 NA -0.58 -5.09 -0.3 6.9e-7 IgG glycosylation; CESC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg04166393 chr7:2884313 GNA12 0.61 8.12 0.45 1.79e-14 Height; CESC cis rs4720575 1.000 rs4720574 chr7:47085597 A/C cg00036614 chr7:47093842 NA -0.41 -6.4 -0.37 7.1e-10 Angiotensin-converting enzyme inhibitor intolerance; CESC cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg26116260 chr4:7069785 GRPEL1 0.84 9.22 0.49 9.86e-18 Monocyte percentage of white cells; CESC cis rs12500824 0.564 rs61183568 chr4:77253029 C/T cg20311846 chr4:77356250 SHROOM3 0.41 8.0 0.44 3.99e-14 Coronary artery disease; CESC cis rs11676348 0.772 rs12694427 chr2:218945045 C/T cg00012203 chr2:219082015 ARPC2 -0.44 -5.47 -0.32 1.02e-7 Ulcerative colitis; CESC cis rs2635047 0.967 rs2576030 chr18:44659166 G/A cg19077165 chr18:44547161 KATNAL2 -0.5 -6.86 -0.39 4.87e-11 Educational attainment; CESC cis rs3845702 0.668 rs12693215 chr2:180826007 A/C cg01881094 chr2:180872142 CWC22 -0.97 -8.87 -0.48 1.12e-16 Schizophrenia; CESC cis rs3747547 0.792 rs72726049 chr9:38049744 C/T cg13774184 chr9:37916125 SHB -0.71 -5.6 -0.33 5.44e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CESC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg12196473 chr3:99536614 MIR548G;C3orf26 -0.47 -6.01 -0.35 5.97e-9 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs3015497 0.624 rs2934700 chr14:51135177 C/A cg26011998 chr14:51135199 SAV1 -0.62 -7.02 -0.4 1.82e-11 Mean platelet volume; CESC cis rs10911363 0.550 rs10911353 chr1:183489203 G/A cg09173681 chr1:183549694 NCF2 0.52 7.59 0.42 5.6e-13 Systemic lupus erythematosus; CESC cis rs7772486 0.790 rs2265919 chr6:146221753 A/G cg05347473 chr6:146136440 FBXO30 0.55 7.05 0.4 1.57e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs12200560 0.524 rs1413525 chr6:97073096 C/T cg06623918 chr6:96969491 KIAA0776 0.47 5.9 0.34 1.13e-8 Coronary heart disease; CESC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg06481639 chr22:41940642 POLR3H 0.6 5.97 0.34 7.49e-9 Vitiligo; CESC cis rs3806843 0.966 rs3756341 chr5:140171194 C/T cg26395211 chr5:140044315 WDR55 -0.41 -5.25 -0.31 3.15e-7 Depressive symptoms (multi-trait analysis); CESC cis rs12451471 0.637 rs12950757 chr17:78096800 T/G cg06718696 chr17:78121285 EIF4A3 0.84 10.38 0.54 2.13e-21 Plateletcrit;Mean corpuscular hemoglobin concentration; CESC cis rs854765 0.583 rs7213225 chr17:17869111 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.55 7.06 0.4 1.45e-11 Total body bone mineral density; CESC cis rs7249921 0.802 rs1046345 chr19:35660752 C/T cg15419183 chr19:35660584 FXYD5 0.56 8.36 0.46 3.57e-15 Platelet count; CESC cis rs7020830 0.830 rs17487601 chr9:37213641 G/A cg14294708 chr9:37120828 ZCCHC7 1.19 21.64 0.8 1.68e-60 Schizophrenia; CESC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.51 -0.32 8.53e-8 Lung cancer; CESC cis rs12410462 0.901 rs2814090 chr1:227658444 C/G cg04117972 chr1:227635322 NA -0.62 -6.2 -0.36 2.11e-9 Major depressive disorder; CESC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg24642844 chr7:1081250 C7orf50 -0.76 -9.35 -0.5 3.75e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC trans rs11039798 1.000 rs3902928 chr11:48581458 A/T cg15704280 chr7:45808275 SEPT13 0.66 6.21 0.36 2.01e-9 Axial length; CESC cis rs72945132 0.882 rs7116191 chr11:70159781 G/A cg00319359 chr11:70116639 PPFIA1 0.78 7.71 0.43 2.52e-13 Coronary artery disease; CESC cis rs933688 1.000 rs2059208 chr5:90732065 A/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.09 14.27 0.66 1.2e-34 Smoking behavior; CESC cis rs7264396 0.943 rs224421 chr20:34145461 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -7.06 -0.4 1.46e-11 Total cholesterol levels; CESC cis rs3087591 0.919 rs2285892 chr17:29553485 G/A cg24425628 chr17:29625626 OMG;NF1 -0.43 -5.31 -0.31 2.31e-7 Hip circumference; CESC cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg24308560 chr3:49941425 MST1R 0.62 9.05 0.49 3.27e-17 Intelligence (multi-trait analysis); CESC cis rs6942756 1.000 rs13235749 chr7:128879678 C/G cg02491457 chr7:128862824 NA -0.7 -10.17 -0.53 9.75e-21 White matter hyperintensity burden; CESC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg10053473 chr17:62856997 LRRC37A3 -0.66 -8.92 -0.48 7.58e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2797160 1.000 rs1739357 chr6:126019655 T/G cg05901451 chr6:126070800 HEY2 0.47 6.75 0.38 9.44e-11 Endometrial cancer; CESC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg18230493 chr5:56204884 C5orf35 0.8 9.54 0.51 9.74e-19 Initial pursuit acceleration; CESC cis rs7072216 0.763 rs8181292 chr10:100175477 A/G cg26618903 chr10:100175079 PYROXD2 -0.37 -5.75 -0.33 2.45e-8 Metabolite levels; CESC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg18016565 chr1:150552671 MCL1 0.34 5.28 0.31 2.67e-7 Tonsillectomy; CESC cis rs67311347 1.000 rs4974017 chr3:40473519 C/T cg01475735 chr3:40494733 NA -0.41 -5.36 -0.31 1.81e-7 Renal cell carcinoma; CESC cis rs2073300 0.609 rs8183135 chr20:23384284 C/T cg16736954 chr20:23401023 NAPB 0.8 6.25 0.36 1.67e-9 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs561341 0.941 rs736678 chr17:30347423 G/T cg12193833 chr17:30244370 NA -0.73 -6.51 -0.37 3.83e-10 Hip circumference adjusted for BMI; CESC cis rs6912958 0.781 rs7750207 chr6:88303967 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.59 -0.38 2.31e-10 Monocyte percentage of white cells; CESC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg23985595 chr17:80112537 CCDC57 -0.42 -6.6 -0.38 2.18e-10 Life satisfaction; CESC cis rs6582630 0.548 rs8189608 chr12:38327775 T/G cg26384229 chr12:38710491 ALG10B -0.42 -5.52 -0.32 8e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs12042938 0.905 rs823160 chr1:231776636 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 6.02 0.35 5.76e-9 Neuranatomic and neurocognitive phenotypes; CESC cis rs9811920 0.638 rs793440 chr3:99643176 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.61 9.74 0.51 2.34e-19 Axial length; CESC cis rs12142240 0.698 rs1475389 chr1:46816429 T/C cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17784606 chr1:1190558 UBE2J2 0.5 6.97 0.39 2.55e-11 Fibrinogen levels; CESC cis rs7085104 0.700 rs10883785 chr10:104603588 A/G cg04362960 chr10:104952993 NT5C2 0.51 6.61 0.38 2.17e-10 Immature fraction of reticulocytes;Schizophrenia; CESC cis rs8044995 0.563 rs73615919 chr16:68398862 C/T cg26727032 chr16:67993705 SLC12A4 -0.51 -5.23 -0.31 3.36e-7 Schizophrenia; CESC cis rs6570726 0.846 rs1935616 chr6:145943512 C/T cg23711669 chr6:146136114 FBXO30 0.87 12.7 0.61 3.59e-29 Lobe attachment (rater-scored or self-reported); CESC cis rs763121 0.925 rs5750654 chr22:39051428 T/C cg06544989 chr22:39130855 UNC84B 0.51 9.42 0.5 2.24e-18 Menopause (age at onset); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23615016 chr1:87794216 LMO4 0.58 7.08 0.4 1.29e-11 Gut microbiome composition (summer); CESC cis rs6831352 0.918 rs17218108 chr4:100055755 T/C cg12011299 chr4:100065546 ADH4 -0.6 -6.62 -0.38 2.04e-10 Alcohol dependence; CESC cis rs7937682 0.632 rs12785809 chr11:111776055 T/A cg09085632 chr11:111637200 PPP2R1B 0.88 11.26 0.57 2.77e-24 Primary sclerosing cholangitis; CESC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg04166393 chr7:2884313 GNA12 -0.57 -7.3 -0.41 3.42e-12 Height; CESC cis rs7216064 1.000 rs7212293 chr17:65847325 A/G cg07042672 chr17:66097459 LOC651250 -0.61 -7.61 -0.42 4.76e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg26314531 chr2:26401878 FAM59B -0.83 -9.29 -0.5 5.94e-18 Gut microbiome composition (summer); CESC trans rs673604 0.505 rs676614 chr1:36107510 G/T cg04761648 chr13:26829199 CDK8 0.54 6.18 0.35 2.4e-9 Endometrial cancer; CESC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg06481639 chr22:41940642 POLR3H 0.55 5.53 0.32 7.53e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg25208724 chr1:156163844 SLC25A44 -1.02 -19.58 -0.77 2.13e-53 Testicular germ cell tumor; CESC cis rs6570726 0.935 rs368848 chr6:145855281 A/T cg23711669 chr6:146136114 FBXO30 0.8 11.75 0.59 6.33e-26 Lobe attachment (rater-scored or self-reported); CESC cis rs12188164 0.525 rs2561665 chr5:460135 A/G cg16584290 chr5:462447 EXOC3 0.47 7.09 0.4 1.19e-11 Cystic fibrosis severity; CESC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg22307029 chr19:49891270 CCDC155 0.65 7.68 0.43 3.04e-13 Multiple sclerosis; CESC cis rs4595586 0.679 rs1156706 chr12:39372641 G/A cg26384229 chr12:38710491 ALG10B 0.44 6.31 0.36 1.15e-9 Morning vs. evening chronotype; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23019286 chr1:227728774 NA -0.41 -6.1 -0.35 3.69e-9 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg08721840 chr1:155293541 RUSC1;C1orf104 -0.43 -6.13 -0.35 3.1e-9 Gambling; CESC trans rs11098499 0.865 rs9996417 chr4:120295862 T/C cg25214090 chr10:38739885 LOC399744 0.68 9.23 0.49 8.9e-18 Corneal astigmatism; CESC cis rs6540559 0.673 rs7511996 chr1:210018473 C/A cg21951975 chr1:209979733 IRF6 0.55 6.64 0.38 1.75e-10 Cleft lip with or without cleft palate; CESC cis rs17539620 0.624 rs62432746 chr6:154838986 A/G cg20019720 chr6:154832845 CNKSR3 0.46 6.06 0.35 4.57e-9 Lipoprotein (a) levels; CESC trans rs1814175 0.645 rs10839448 chr11:49938930 G/A cg03929089 chr4:120376271 NA -0.89 -14.83 -0.67 1.17e-36 Height; CESC cis rs7246657 0.943 rs4802766 chr19:37981933 T/C cg23950597 chr19:37808831 NA -0.64 -6.69 -0.38 1.3e-10 Coronary artery calcification; CESC cis rs920590 0.758 rs7010174 chr8:19661930 G/C cg01411142 chr8:19674711 INTS10 0.52 5.86 0.34 1.39e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs6076065 0.894 rs2243448 chr20:23378345 G/A cg11657817 chr20:23433608 CST11 0.4 6.02 0.35 5.68e-9 Facial morphology (factor 15, philtrum width); CESC cis rs959260 1.000 rs9909076 chr17:73384809 G/T cg12999837 chr17:73267436 MIF4GD -0.48 -5.67 -0.33 3.72e-8 Systemic lupus erythematosus; CESC cis rs863345 0.935 rs10797025 chr1:158519525 T/C cg12129480 chr1:158549410 OR10X1 -0.33 -6.56 -0.37 2.84e-10 Pneumococcal bacteremia; CESC cis rs57221529 0.709 rs72703034 chr5:577101 C/T cg16447950 chr5:562315 NA -0.64 -6.81 -0.39 6.59e-11 Lung disease severity in cystic fibrosis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17483139 chr1:1822401 GNB1 0.58 6.43 0.37 5.89e-10 Gut microbiome composition (summer); CESC cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg11890956 chr21:40555474 PSMG1 0.69 9.49 0.5 1.38e-18 Cognitive function; CESC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.68 -0.33 3.46e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CESC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg18402987 chr7:1209562 NA 0.76 7.79 0.43 1.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg00409905 chr10:38381863 ZNF37A 0.45 5.99 0.35 6.64e-9 Extrinsic epigenetic age acceleration; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21487261 chr17:79368981 NA -0.57 -6.56 -0.37 2.85e-10 Gut microbiome composition (summer); CESC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg23283495 chr1:209979779 IRF6 0.5 7.05 0.4 1.51e-11 Cleft lip with or without cleft palate; CESC cis rs3026101 0.671 rs56019636 chr17:5297551 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.68 0.33 3.57e-8 Body mass index; CESC cis rs11098499 0.697 rs28655325 chr4:120372999 A/G cg09307838 chr4:120376055 NA 0.94 13.54 0.64 4.29e-32 Corneal astigmatism; CESC cis rs992157 0.735 rs10932765 chr2:219099484 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.69 9.72 0.51 2.63e-19 Colorectal cancer; CESC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg12756686 chr19:29218302 NA 0.59 7.62 0.42 4.52e-13 Methadone dose in opioid dependence; CESC cis rs6714710 0.603 rs55776387 chr2:98405034 T/C cg26665480 chr2:98280029 ACTR1B 0.6 8.26 0.45 6.99e-15 Posterior cortical atrophy and Alzheimer's disease; CESC cis rs6499255 1.000 rs73579458 chr16:69804764 G/C cg15192750 chr16:69999425 NA 0.48 5.95 0.34 8.45e-9 IgE levels; CESC cis rs6563842 0.563 rs9603786 chr13:41316364 G/A cg21288729 chr13:41239152 FOXO1 0.6 7.78 0.43 1.66e-13 Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CESC cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg24879335 chr3:133465180 TF 0.34 6.26 0.36 1.53e-9 Iron status biomarkers; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg17059624 chr11:85358760 TMEM126A -0.43 -6.21 -0.36 2.03e-9 Gambling; CESC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg03709012 chr19:19516395 GATAD2A 0.97 14.12 0.66 3.77e-34 Tonsillectomy; CESC cis rs12188164 0.515 rs17562461 chr5:411361 C/T cg26850624 chr5:429559 AHRR -0.43 -5.64 -0.33 4.34e-8 Cystic fibrosis severity; CESC cis rs854765 0.583 rs62064156 chr17:17822480 C/T cg16928487 chr17:17741425 SREBF1 -0.59 -10.25 -0.53 5.56e-21 Total body bone mineral density; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20693608 chr4:113152836 AP1AR 0.56 6.25 0.36 1.59e-9 Gut microbiome composition (summer); CESC cis rs7520050 0.931 rs11211198 chr1:46282673 G/A cg03146154 chr1:46216737 IPP -0.47 -6.19 -0.36 2.34e-9 Red blood cell count;Reticulocyte count; CESC trans rs7098100 0.596 rs2666781 chr10:22205676 C/A cg20133923 chr20:3027467 MRPS26 0.41 6.04 0.35 5.2e-9 Breast cancer; CESC cis rs642803 1.000 rs642803 chr11:65560620 C/T cg10518572 chr11:65560635 OVOL1 0.31 6.65 0.38 1.71e-10 Urate levels; CESC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg07211511 chr3:129823064 LOC729375 -0.58 -7.33 -0.41 2.74e-12 Blood pressure (smoking interaction); CESC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg13722127 chr7:150037890 RARRES2 0.36 5.08 0.3 7.12e-7 Blood protein levels;Circulating chemerin levels; CESC cis rs2191566 0.664 rs55958002 chr19:44543788 A/T cg20607764 chr19:44506953 ZNF230 -0.43 -5.52 -0.32 8.25e-8 Acute lymphoblastic leukemia (childhood); CESC cis rs17253792 0.822 rs76557162 chr14:56064701 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.85 6.13 0.35 3.15e-9 Putamen volume; CESC cis rs2645694 0.533 rs2703125 chr4:77819900 T/C cg18351406 chr4:77819688 ANKRD56 0.54 6.79 0.38 7.56e-11 Emphysema distribution in smoking; CESC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg18446336 chr7:2847575 GNA12 -0.38 -5.58 -0.32 5.92e-8 Height; CESC cis rs9790314 1.000 rs336585 chr3:161081670 A/G cg04691961 chr3:161091175 C3orf57 -0.43 -5.47 -0.32 1.07e-7 Morning vs. evening chronotype; CESC cis rs933688 1.000 rs11948075 chr5:90680579 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 12.36 0.6 5.17e-28 Smoking behavior; CESC cis rs1215050 0.740 rs783916 chr4:99026264 A/C cg05340658 chr4:99064831 C4orf37 -0.65 -9.09 -0.49 2.37e-17 Waist-to-hip ratio adjusted for body mass index; CESC cis rs7072216 0.763 rs942805 chr10:100168372 G/A cg26618903 chr10:100175079 PYROXD2 -0.37 -5.55 -0.32 7.01e-8 Metabolite levels; CESC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg03806693 chr22:41940476 POLR3H -1.14 -13.32 -0.63 2.55e-31 Vitiligo; CESC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg23803603 chr1:2058230 PRKCZ -0.34 -5.8 -0.34 1.9e-8 Height; CESC cis rs7219021 0.885 rs3848457 chr17:46866026 C/T cg16584676 chr17:46985605 UBE2Z -0.55 -6.19 -0.36 2.22e-9 Schizophrenia or bipolar disorder; CESC cis rs9818941 0.793 rs9874758 chr3:157735625 A/G cg08654915 chr3:157813417 NA -0.46 -7.48 -0.42 1.07e-12 Height; CESC trans rs6981523 0.566 rs34162231 chr8:11003088 A/T cg15556689 chr8:8085844 FLJ10661 -0.53 -6.22 -0.36 1.98e-9 Neuroticism; CESC cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg18180107 chr4:99064573 C4orf37 0.4 5.3 0.31 2.48e-7 Colonoscopy-negative controls vs population controls; CESC cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg03676636 chr4:99064102 C4orf37 0.34 5.15 0.3 5.1e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08209163 chr13:28024472 MTIF3 0.66 8.14 0.45 1.6e-14 Gut microbiome composition (summer); CESC cis rs7208859 0.623 rs7219361 chr17:29080393 G/A cg19761014 chr17:28927070 LRRC37B2 0.78 6.42 0.37 6.22e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg26314531 chr2:26401878 FAM59B -0.85 -9.23 -0.49 8.65e-18 Gut microbiome composition (summer); CESC cis rs4237845 0.537 rs4237844 chr12:58267987 A/G cg02175503 chr12:58329896 NA -0.49 -5.84 -0.34 1.52e-8 Intelligence (multi-trait analysis); CESC cis rs1577917 1.000 rs10455456 chr6:86670322 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -5.92 -0.34 9.76e-9 Response to antipsychotic treatment; CESC cis rs2847281 0.587 rs2542152 chr18:12782761 C/T cg24209723 chr18:12913133 NA -0.4 -5.43 -0.32 1.28e-7 C-reactive protein levels;Esophageal cancer (squamous cell); CESC trans rs8073060 0.586 rs225296 chr17:33924847 C/G cg19694781 chr19:47549865 TMEM160 -0.7 -6.88 -0.39 4.3e-11 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CESC cis rs11098499 0.615 rs28850368 chr4:120554313 G/A cg09307838 chr4:120376055 NA 0.78 10.46 0.54 1.13e-21 Corneal astigmatism; CESC cis rs3857536 0.741 rs9363558 chr6:66937260 C/T cg07460842 chr6:66804631 NA -0.42 -5.34 -0.31 1.96e-7 Blood trace element (Cu levels); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24048372 chr5:93954560 C5orf36;ANKRD32 0.58 6.71 0.38 1.16e-10 Gut microbiome composition (summer); CESC cis rs854765 0.647 rs8066764 chr17:17974668 C/T cg16928487 chr17:17741425 SREBF1 -0.51 -8.37 -0.46 3.39e-15 Total body bone mineral density; CESC cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg25517755 chr10:38738941 LOC399744 -0.47 -6.05 -0.35 4.86e-9 Extrinsic epigenetic age acceleration; CESC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.36 -0.31 1.82e-7 Lung cancer; CESC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 9.86 0.52 9.4e-20 Prudent dietary pattern; CESC cis rs763014 0.833 rs3743904 chr16:632767 A/G cg00908189 chr16:619842 PIGQ 0.67 9.42 0.5 2.33e-18 Height; CESC cis rs2290159 0.800 rs56363132 chr3:12680403 T/C cg23032965 chr3:12705835 RAF1 0.54 5.72 0.33 2.81e-8 Cholesterol, total; CESC cis rs7124681 0.584 rs11039448 chr11:47918416 G/T cg18512352 chr11:47633146 NA -0.38 -5.92 -0.34 9.8e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CESC cis rs11690935 0.550 rs6746701 chr2:172869255 G/A cg13550731 chr2:172543902 DYNC1I2 0.48 6.51 0.37 3.84e-10 Schizophrenia; CESC cis rs2180341 0.814 rs6569488 chr6:127726256 C/T cg24812749 chr6:127587940 RNF146 0.84 12.05 0.59 5.93e-27 Breast cancer; CESC cis rs593982 0.920 rs76925283 chr11:65548108 C/T cg08755490 chr11:65554678 OVOL1 -1.26 -10.54 -0.54 6.22e-22 Atopic dermatitis; CESC cis rs1808579 0.904 rs1631685 chr18:21134239 C/T cg14672496 chr18:21087552 C18orf8 0.41 5.92 0.34 1e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CESC trans rs1814175 0.588 rs1794144 chr11:49918233 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.76 3.64e-51 Height; CESC cis rs863345 0.564 rs10908667 chr1:158500121 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -6.84 -0.39 5.49e-11 Pneumococcal bacteremia; CESC cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg03467027 chr4:99064603 C4orf37 0.48 5.94 0.34 9.13e-9 Colonoscopy-negative controls vs population controls; CESC cis rs3096299 0.869 rs748941 chr16:89440754 T/A cg02187348 chr16:89574699 SPG7 0.55 7.32 0.41 2.92e-12 Multiple myeloma (IgH translocation); CESC cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg22875332 chr1:76189707 ACADM 0.66 7.95 0.44 5.33e-14 Blood metabolite levels;Acylcarnitine levels; CESC trans rs877282 0.891 rs11253355 chr10:768367 C/G cg22713356 chr15:30763199 NA 1.17 11.73 0.58 7.23e-26 Uric acid levels; CESC cis rs2425143 1.000 rs12479473 chr20:34398628 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.2 -0.4 6.33e-12 Blood protein levels; CESC cis rs6580649 0.941 rs72644842 chr12:48448274 A/G cg24011408 chr12:48396354 COL2A1 -0.42 -5.28 -0.31 2.67e-7 Lung cancer; CESC cis rs3008870 1.000 rs2815357 chr1:67491854 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.98 13.07 0.63 1.83e-30 Lymphocyte percentage of white cells; CESC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 13.06 0.63 1.98e-30 Platelet count; CESC cis rs939658 0.805 rs1915726 chr15:79420620 C/G cg17916960 chr15:79447300 NA -0.37 -6.13 -0.35 3.21e-9 Refractive error; CESC cis rs11785400 0.793 rs4430071 chr8:143737680 T/C cg24634471 chr8:143751801 JRK 0.46 5.91 0.34 1.06e-8 Schizophrenia; CESC cis rs951366 0.576 rs1832775 chr1:205734032 C/T cg17178900 chr1:205818956 PM20D1 -0.42 -5.3 -0.31 2.48e-7 Menarche (age at onset); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg14796370 chr20:61273660 SLCO4A1 -0.44 -6.11 -0.35 3.58e-9 Prostate cancer (SNP x SNP interaction); CESC trans rs731565 1.000 rs1525254 chr7:147406140 C/T cg13413955 chr9:842914 DMRT1 -0.69 -6.43 -0.37 6.09e-10 Diabetic kidney disease; CESC cis rs9815354 0.812 rs4577439 chr3:41952540 T/A cg03022575 chr3:42003672 ULK4 0.68 5.92 0.34 9.9e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs12188164 0.580 rs2672755 chr5:457249 G/T cg16584290 chr5:462447 EXOC3 0.45 6.75 0.38 9.17e-11 Cystic fibrosis severity; CESC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg11247378 chr22:39784982 NA -0.64 -9.61 -0.51 5.94e-19 Intelligence (multi-trait analysis); CESC cis rs10911251 0.528 rs2333622 chr1:183075456 T/C ch.1.3577855R chr1:183094577 LAMC1 0.88 14.2 0.66 2.05e-34 Colorectal cancer; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg10341310 chr8:66582206 MTFR1 -0.46 -6.36 -0.36 8.76e-10 Gut microbiota (bacterial taxa); CESC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg01341218 chr17:43662625 NA 0.91 11.23 0.57 3.32e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs10791097 0.609 rs3751039 chr11:130773076 A/G cg12179176 chr11:130786555 SNX19 -0.78 -13.75 -0.65 7.93e-33 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs71277158 0.688 rs73879163 chr3:169770802 T/C cg04067573 chr3:169899625 PHC3 0.52 5.4 0.31 1.5e-7 Prostate cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg16349277 chr4:83323642 NA -0.6 -7.11 -0.4 1.05e-11 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09910967 chr6:139456200 HECA 0.58 6.87 0.39 4.59e-11 Gut microbiome composition (summer); CESC cis rs9399135 1.000 rs1014021 chr6:135334600 C/T cg24558204 chr6:135376177 HBS1L -0.49 -6.73 -0.38 1.07e-10 Red blood cell count; CESC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg12311346 chr5:56204834 C5orf35 -0.64 -7.96 -0.44 4.98e-14 Initial pursuit acceleration; CESC cis rs897984 0.806 rs12928852 chr16:30943988 C/T cg02466173 chr16:30829666 NA 0.49 8.33 0.46 4.26e-15 Dementia with Lewy bodies; CESC cis rs3008870 1.000 rs2755240 chr1:67477339 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.01 13.78 0.65 5.96e-33 Lymphocyte percentage of white cells; CESC cis rs7649275 0.541 rs898419 chr3:53783785 A/C cg21503701 chr3:53781065 CACNA1D -0.39 -5.2 -0.3 3.9e-7 Trans fatty acid levels; CESC cis rs2625529 0.652 rs2415128 chr15:72191073 T/C cg16672083 chr15:72433130 SENP8 0.42 6.19 0.36 2.34e-9 Red blood cell count; CESC cis rs7555523 0.830 rs6660601 chr1:165695855 C/T cg24409356 chr1:165738333 TMCO1 0.89 8.13 0.45 1.7e-14 Intraocular pressure;Glaucoma (high intraocular pressure); CESC cis rs798766 1.000 rs798754 chr4:1720757 A/G cg05874882 chr4:1763078 NA -0.58 -8.39 -0.46 2.84e-15 Bladder cancer;Urinary bladder cancer; CESC cis rs2455799 0.573 rs2470539 chr3:15717844 C/T cg16303742 chr3:15540471 COLQ -0.39 -6.04 -0.35 5.19e-9 Mean platelet volume; CESC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg20151795 chr6:28129481 ZNF389 0.44 5.74 0.33 2.6e-8 Depression; CESC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 9.46 0.5 1.68e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10838687 1.000 rs753993 chr11:47349969 C/A cg25783544 chr11:47291846 MADD 0.57 6.82 0.39 6.3e-11 Proinsulin levels; CESC cis rs453301 0.624 rs330058 chr8:9089809 G/A cg17143192 chr8:8559678 CLDN23 -0.45 -5.41 -0.32 1.42e-7 Joint mobility (Beighton score); CESC cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg25019033 chr10:957182 NA -0.6 -6.55 -0.37 3.04e-10 Eosinophil percentage of granulocytes; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg09379601 chr19:12992224 DNASE2 0.48 6.42 0.37 6.12e-10 Systemic lupus erythematosus; CESC cis rs1451375 0.617 rs2876829 chr7:50566762 A/G cg14593290 chr7:50529359 DDC 0.52 6.62 0.38 1.96e-10 Malaria; CESC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg24818145 chr4:99064322 C4orf37 0.39 5.13 0.3 5.74e-7 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19451033 chr5:141276143 LOC729080 -0.68 -7.91 -0.44 6.82e-14 Gut microbiome composition (summer); CESC cis rs3733585 0.781 rs13103690 chr4:9972778 T/G cg02734326 chr4:10020555 SLC2A9 -0.46 -6.74 -0.38 9.94e-11 Cleft plate (environmental tobacco smoke interaction); CESC cis rs6582630 0.537 rs10785436 chr12:38461040 G/C cg13010199 chr12:38710504 ALG10B 0.44 5.79 0.33 2.02e-8 Drug-induced liver injury (flucloxacillin); CESC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg20607287 chr7:12443886 VWDE -0.7 -8.49 -0.46 1.46e-15 Coronary artery disease; CESC cis rs6500602 0.727 rs55939215 chr16:4541390 C/G cg08645402 chr16:4508243 NA 0.57 9.16 0.49 1.5e-17 Schizophrenia; CESC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg23985595 chr17:80112537 CCDC57 -0.41 -6.57 -0.37 2.6200000000000003e-10 Life satisfaction; CESC cis rs5758659 0.652 rs133300 chr22:42389839 A/G cg19513890 chr22:42538836 CYP2D7P1 -0.4 -5.62 -0.33 4.9e-8 Cognitive function; CESC cis rs10254118 0.757 rs7788086 chr7:133135206 C/T cg10665199 chr7:133106180 EXOC4 0.58 7.98 0.44 4.39e-14 Intelligence (multi-trait analysis); CESC cis rs6738485 0.507 rs66569888 chr2:106886967 G/A cg16099169 chr2:106886729 NA -0.74 -7.47 -0.42 1.15e-12 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CESC cis rs8067354 0.681 rs76856339 chr17:57800966 G/A cg02344993 chr17:57696989 CLTC 0.58 6.14 0.35 3.08e-9 Hemoglobin concentration; CESC cis rs2073300 0.609 rs12625164 chr20:23354269 T/C cg12062639 chr20:23401060 NAPB 1.03 7.98 0.44 4.32e-14 Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg24549020 chr5:56110836 MAP3K1 -0.59 -6.42 -0.37 6.32e-10 Initial pursuit acceleration; CESC cis rs4722166 0.564 rs1800797 chr7:22766221 A/G cg26061582 chr7:22766209 IL6 0.52 5.79 0.34 2.01e-8 Lung cancer; CESC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg07507251 chr3:52567010 NT5DC2 0.4 7.01 0.4 1.94e-11 Bipolar disorder; CESC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg18230493 chr5:56204884 C5orf35 0.71 8.41 0.46 2.5e-15 Initial pursuit acceleration; CESC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg23281280 chr6:28129359 ZNF389 0.55 6.99 0.39 2.28e-11 Parkinson's disease; CESC cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg04450456 chr4:17643702 FAM184B 0.36 5.06 0.3 7.87e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs10097731 0.901 rs10464932 chr8:82042901 T/G cg25230327 chr8:82042993 NA -0.56 -6.33 -0.36 1.06e-9 Serum total protein level; CESC cis rs4973397 0.810 rs12999051 chr2:232276992 T/A cg09339159 chr2:232260559 B3GNT7 0.59 6.03 0.35 5.62e-9 Anti-saccade response; CESC trans rs9329221 0.621 rs522483 chr8:9812969 C/G cg15556689 chr8:8085844 FLJ10661 -0.49 -6.38 -0.36 7.81e-10 Neuroticism; CESC cis rs6933660 0.720 rs6913515 chr6:151753470 G/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.48 -6.3 -0.36 1.22e-9 Menarche (age at onset); CESC cis rs6570726 0.935 rs385134 chr6:145851005 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.62 0.38 1.96e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7000551 0.715 rs2469745 chr8:22343464 C/T cg12081754 chr8:22256438 SLC39A14 0.42 5.65 0.33 4.03e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CESC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg05564831 chr3:52568323 NT5DC2 0.45 6.96 0.39 2.68e-11 Bipolar disorder; CESC cis rs637571 0.522 rs556643 chr11:65733289 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.44 6.43 0.37 5.96e-10 Eosinophil percentage of white cells; CESC cis rs1610096 0.538 rs2279796 chr19:1059004 A/G cg18950617 chr19:1066959 HMHA1 -0.43 -5.21 -0.3 3.77e-7 Neutrophil percentage of granulocytes; CESC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg04518342 chr5:131593106 PDLIM4 0.4 6.15 0.35 2.9e-9 Breast cancer; CESC cis rs11690935 0.550 rs6718013 chr2:172869185 A/G cg13550731 chr2:172543902 DYNC1I2 0.49 6.75 0.38 9.18e-11 Schizophrenia; CESC trans rs11098499 0.754 rs4107728 chr4:120253910 G/A cg25214090 chr10:38739885 LOC399744 0.65 9.0 0.48 4.51e-17 Corneal astigmatism; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg07355551 chr20:2489285 ZNF343 0.49 6.37 0.36 8.11e-10 Gut microbiota (bacterial taxa); CESC cis rs4595586 0.545 rs11611625 chr12:39387207 T/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg11764359 chr7:65958608 NA -0.79 -9.62 -0.51 5.56e-19 Aortic root size; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02400751 chr11:74459640 RNF169 -0.62 -7.4 -0.41 1.79e-12 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg20725035 chr3:148709344 GYG1 0.63 7.29 0.41 3.64e-12 Gut microbiome composition (summer); CESC cis rs4409675 0.576 rs6565 chr1:28213157 T/C cg23691781 chr1:28212827 C1orf38 0.29 5.67 0.33 3.73e-8 Corneal astigmatism; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24397552 chr15:40226086 EIF2AK4 -0.63 -7.45 -0.42 1.29e-12 Gut microbiome composition (summer); CESC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg23034840 chr1:205782522 SLC41A1 -0.69 -9.24 -0.49 8.23e-18 Monocyte percentage of white cells; CESC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg11764359 chr7:65958608 NA -0.72 -9.5 -0.5 1.33e-18 Aortic root size; CESC cis rs644799 1.000 rs525404 chr11:95566520 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.68 8.58 0.47 8.14e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg24675658 chr1:53192096 ZYG11B -0.66 -9.13 -0.49 1.78e-17 Monocyte count; CESC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 7.96 0.44 5.13e-14 Bipolar disorder; CESC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg00800038 chr16:89945340 TCF25 -0.92 -7.64 -0.42 4.02e-13 Skin colour saturation; CESC cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg11742103 chr11:62369870 EML3;MTA2 0.64 9.58 0.51 7.23e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CESC cis rs6460942 0.915 rs62448600 chr7:12454944 T/G cg10578991 chr7:12443926 VWDE -0.5 -5.52 -0.32 7.93e-8 Coronary artery disease; CESC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.12 22.27 0.81 1.17e-62 Prudent dietary pattern; CESC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg24675658 chr1:53192096 ZYG11B 0.64 7.96 0.44 5.13e-14 Monocyte count; CESC cis rs7259376 0.875 rs1991830 chr19:22514730 G/A cg02657401 chr19:22469223 NA -0.26 -5.25 -0.31 3.14e-7 Menopause (age at onset); CESC cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.76 -12.18 -0.6 2.08e-27 Personality dimensions; CESC cis rs6570726 0.846 rs6914304 chr6:145921017 T/C cg23711669 chr6:146136114 FBXO30 0.83 12.25 0.6 1.19e-27 Lobe attachment (rater-scored or self-reported); CESC cis rs6669008 1.000 rs55912359 chr1:114167099 C/T cg26035817 chr1:114414802 PTPN22 0.43 6.23 0.36 1.85e-9 Bacteremia; CESC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg24768116 chr2:27665128 KRTCAP3 -0.3 -5.57 -0.32 6.2e-8 Total body bone mineral density; CESC cis rs9457247 1.000 rs430097 chr6:167405073 A/G cg07741184 chr6:167504864 NA 0.28 5.1 0.3 6.54e-7 Crohn's disease; CESC cis rs7301826 1.000 rs2001483 chr12:131318645 A/G cg11011512 chr12:131303247 STX2 0.4 5.09 0.3 6.86e-7 Plasma plasminogen activator levels; CESC cis rs7246657 0.943 rs13345116 chr19:37847098 A/T cg23950597 chr19:37808831 NA -0.55 -6.09 -0.35 3.96e-9 Coronary artery calcification; CESC cis rs9875589 0.794 rs2117039 chr3:13963330 T/C cg19554555 chr3:13937349 NA 0.39 5.08 0.3 7.24e-7 Ovarian reserve; CESC cis rs6752107 0.967 rs56227616 chr2:234157741 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.43 5.91 0.34 1.02e-8 Crohn's disease;Inflammatory bowel disease; CESC cis rs11997175 0.583 rs12680811 chr8:33778426 A/C ch.8.33884649F chr8:33765107 NA 0.53 6.81 0.39 6.5e-11 Body mass index; CESC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg23281280 chr6:28129359 ZNF389 0.59 8.21 0.45 9.45e-15 Depression; CESC trans rs629535 0.773 rs630235 chr8:70033529 T/G cg21567404 chr3:27674614 NA 0.93 11.25 0.57 2.83e-24 Dupuytren's disease; CESC cis rs1949733 0.958 rs3103069 chr4:8509451 T/G cg11789530 chr4:8429930 ACOX3 -0.74 -10.08 -0.53 1.94e-20 Response to antineoplastic agents; CESC cis rs17826219 0.636 rs4055314 chr17:29079769 T/C cg19761014 chr17:28927070 LRRC37B2 0.78 6.41 0.37 6.61e-10 Body mass index; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg09262369 chr15:66648794 TIPIN -0.48 -6.0 -0.35 6.61e-9 Gut microbiota (bacterial taxa); CESC cis rs2346177 0.554 rs36006825 chr2:46708945 G/T cg02822958 chr2:46747628 ATP6V1E2 0.44 5.47 0.32 1.03e-7 HDL cholesterol; CESC cis rs1642645 0.915 rs6696291 chr1:42500421 C/T cg16685388 chr1:42384056 HIVEP3 -0.35 -5.08 -0.3 7.05e-7 Left ventricular obstructive tract defect (maternal effect); CESC cis rs6062302 0.522 rs2297427 chr20:62221364 G/A cg09650180 chr20:62225654 GMEB2 -0.8 -9.13 -0.49 1.75e-17 Glioblastoma; CESC cis rs10857712 0.703 rs12253520 chr10:135235321 C/A cg01444801 chr10:135216882 MTG1 -0.46 -5.26 -0.31 3.03e-7 Systemic lupus erythematosus; CESC cis rs9488822 0.676 rs6918059 chr6:116349041 C/T cg26893134 chr6:116381904 FRK 0.25 6.16 0.35 2.74e-9 Cholesterol, total;LDL cholesterol; CESC cis rs611744 0.550 rs57045491 chr8:109279120 A/C cg21045802 chr8:109455806 TTC35 0.45 5.56 0.32 6.42e-8 Dupuytren's disease; CESC cis rs1869839 0.527 rs673535 chr7:114364104 C/G cg05338976 chr7:114561850 MDFIC 0.36 5.06 0.3 7.75e-7 Crohn's disease; CESC cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg26818010 chr10:134567672 INPP5A -0.91 -11.33 -0.57 1.63e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs3126085 0.935 rs1390487 chr1:152194601 G/A cg26876637 chr1:152193138 HRNR 0.46 5.23 0.31 3.49e-7 Atopic dermatitis; CESC cis rs9640161 0.742 rs2108851 chr7:150019634 T/C cg21361702 chr7:150065534 REPIN1 0.56 6.54 0.37 3.2e-10 Blood protein levels;Circulating chemerin levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg07393419 chr7:72741883 FKBP6;TRIM50 -0.47 -6.0 -0.35 6.55e-9 Gut microbiome composition (summer); CESC cis rs4555082 0.789 rs2816649 chr14:105708326 A/G cg06808227 chr14:105710500 BRF1 -0.52 -6.44 -0.37 5.58e-10 Mean platelet volume;Platelet distribution width; CESC cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg03467027 chr4:99064603 C4orf37 0.43 5.47 0.32 1.02e-7 Colonoscopy-negative controls vs population controls; CESC cis rs60154123 0.730 rs652256 chr1:210465017 T/C cg21951975 chr1:209979733 IRF6 0.45 6.15 0.35 2.92e-9 Coronary artery disease; CESC cis rs1005277 0.579 rs1780121 chr10:38529437 C/A cg25517755 chr10:38738941 LOC399744 -0.49 -6.39 -0.37 7.49e-10 Extrinsic epigenetic age acceleration; CESC cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg10523679 chr1:76189770 ACADM 0.72 8.31 0.45 5.07e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg13902645 chr11:5959945 NA -0.48 -5.76 -0.33 2.36e-8 DNA methylation (variation); CESC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.76 -0.51 2.03e-19 Alzheimer's disease; CESC cis rs933688 1.000 rs1035477 chr5:90743325 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.1 12.13 0.6 3.17e-27 Smoking behavior; CESC cis rs8040855 0.627 rs12913859 chr15:85638418 A/G cg08123816 chr15:85640762 PDE8A -0.41 -6.09 -0.35 4.03e-9 Bulimia nervosa; CESC cis rs11191270 0.554 rs10444022 chr10:104084889 A/G cg15320455 chr10:103880129 LDB1 0.6 5.74 0.33 2.56e-8 Intelligence (multi-trait analysis); CESC cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg05283184 chr6:79620031 NA -0.42 -6.42 -0.37 6.18e-10 Intelligence (multi-trait analysis); CESC cis rs1971256 0.500 rs3912291 chr6:151818210 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.59 5.16 0.3 4.83e-7 Endometriosis; CESC cis rs710216 0.843 rs710220 chr1:43415346 G/T cg07803811 chr1:43423981 SLC2A1 0.49 5.51 0.32 8.47e-8 Red cell distribution width; CESC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg17971929 chr21:40555470 PSMG1 0.87 12.83 0.62 1.2e-29 Cognitive function; CESC cis rs916888 0.773 rs199445 chr17:44817408 C/T cg01570182 chr17:44337453 NA 0.87 10.01 0.52 3.3e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2204008 0.811 rs11525004 chr12:38333807 T/A cg26384229 chr12:38710491 ALG10B 0.73 10.9 0.56 4.29e-23 Bladder cancer; CESC cis rs7312774 0.618 rs11612483 chr12:107346884 A/G cg16260113 chr12:107380972 MTERFD3 0.82 7.48 0.42 1.11e-12 Severe influenza A (H1N1) infection; CESC cis rs7772486 0.806 rs4243478 chr6:146284560 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -10.76 -0.55 1.22e-22 Lobe attachment (rater-scored or self-reported); CESC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg12718519 chr1:2058417 PRKCZ -0.25 -5.31 -0.31 2.36e-7 Height; CESC cis rs10751667 0.666 rs12295141 chr11:947065 G/A cg06064525 chr11:970664 AP2A2 -0.48 -9.44 -0.5 1.95e-18 Alzheimer's disease (late onset); CESC cis rs11651000 0.625 rs58067360 chr17:45819587 G/C cg00777063 chr17:45855553 NA -0.37 -5.39 -0.31 1.53e-7 IgG glycosylation; CESC cis rs9486719 0.857 rs13208321 chr6:96860354 C/T cg06623918 chr6:96969491 KIAA0776 -0.63 -7.1 -0.4 1.17e-11 Migraine;Coronary artery disease; CESC cis rs3096299 0.900 rs4785666 chr16:89462771 C/G cg02187348 chr16:89574699 SPG7 0.5 6.57 0.37 2.63e-10 Multiple myeloma (IgH translocation); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg21119375 chr2:44393385 NA 0.46 6.03 0.35 5.62e-9 Fibrinogen levels; CESC cis rs11252926 0.589 rs12359901 chr10:475068 A/G cg18196295 chr10:418757 DIP2C -0.53 -7.16 -0.4 7.94e-12 Psychosis in Alzheimer's disease; CESC cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg21573476 chr21:45109991 RRP1B -0.49 -6.79 -0.38 7.38e-11 Mean corpuscular volume; CESC cis rs959260 1.000 rs2053158 chr17:73393459 A/T cg20590849 chr17:73267439 MIF4GD 0.54 6.32 0.36 1.11e-9 Systemic lupus erythematosus; CESC cis rs9287719 0.967 rs4519489 chr2:10739087 A/T cg00105475 chr2:10696890 NA 0.39 5.61 0.33 4.96e-8 Prostate cancer; CESC cis rs56399783 0.808 rs73049331 chr7:2799911 C/T cg19731401 chr7:2775893 GNA12 0.63 5.9 0.34 1.09e-8 Childhood ear infection; CESC cis rs9815354 0.812 rs73071315 chr3:41805887 T/C cg03022575 chr3:42003672 ULK4 0.7 6.18 0.35 2.42e-9 Pulse pressure;Diastolic blood pressure; CESC cis rs7267979 1.000 rs2387881 chr20:25378172 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -17.82 -0.74 3.14e-47 Liver enzyme levels (alkaline phosphatase); CESC cis rs11583043 0.874 rs6577222 chr1:101420502 C/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.55 6.12 0.35 3.39e-9 Ulcerative colitis;Inflammatory bowel disease; CESC cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg17427002 chr7:12443146 VWDE -0.52 -5.04 -0.3 8.67e-7 Coronary artery disease; CESC cis rs2011503 1.000 rs1989867 chr19:19447470 A/G cg11584989 chr19:19387371 SF4 -0.64 -7.79 -0.43 1.51e-13 Bipolar disorder; CESC cis rs9300255 0.506 rs61388686 chr12:123810873 G/A cg05973401 chr12:123451056 ABCB9 0.42 5.35 0.31 1.91e-7 Neutrophil percentage of white cells; CESC cis rs4822044 0.561 rs132781 chr22:42046122 T/G cg06481639 chr22:41940642 POLR3H 0.6 6.16 0.35 2.74e-9 Cannabis dependence symptom count; CESC cis rs11785693 0.862 rs6990234 chr8:4996812 A/G cg26367366 chr8:4980734 NA 0.77 7.52 0.42 8.43e-13 Neuroticism (multi-trait analysis);Neuroticism; CESC cis rs239198 0.578 rs11155708 chr6:101292189 G/A cg09795085 chr6:101329169 ASCC3 0.43 5.26 0.31 2.92e-7 Menarche (age at onset); CESC cis rs6732160 0.774 rs7606271 chr2:73367698 T/G cg01422370 chr2:73384389 NA 0.41 6.84 0.39 5.58e-11 Intelligence (multi-trait analysis); CESC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg08222618 chr4:941054 TMEM175 0.45 6.91 0.39 3.5e-11 Sjögren's syndrome; CESC cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.78 8.21 0.45 9.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs7267979 0.565 rs13040726 chr20:25559881 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.7 -11.11 -0.56 8.86e-24 Liver enzyme levels (alkaline phosphatase); CESC trans rs11818084 0.664 rs2885316 chr10:126003317 T/C cg19462022 chr13:114810756 RASA3 0.39 6.17 0.35 2.48e-9 Clozapine-induced cytotoxicity; CESC cis rs763014 0.931 rs710925 chr16:633354 G/A cg07256732 chr16:621771 PIGQ -0.3 -5.14 -0.3 5.22e-7 Height; CESC cis rs11203032 0.831 rs4417181 chr10:90967093 T/C cg16672925 chr10:90967113 CH25H 0.73 7.12 0.4 1.01e-11 Heart failure; CESC cis rs7829975 0.511 rs2976902 chr8:8341105 T/G cg15556689 chr8:8085844 FLJ10661 0.53 6.51 0.37 3.71e-10 Mood instability; CESC cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.86 -12.58 -0.61 9.34e-29 Systemic lupus erythematosus; CESC cis rs2228479 0.850 rs62054599 chr16:89808850 C/G cg00800038 chr16:89945340 TCF25 -0.88 -7.36 -0.41 2.3e-12 Skin colour saturation; CESC cis rs12145833 0.538 rs9803701 chr1:243391634 T/C cg02356786 chr1:243265016 LOC731275 -0.79 -6.57 -0.37 2.71e-10 Obesity (early onset extreme); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10727759 chr12:50017361 PRPF40B 0.6 7.29 0.41 3.59e-12 Gut microbiome composition (summer); CESC cis rs2119480 0.762 rs376602 chr13:111304944 T/C cg16216153 chr13:111290848 CARKD -0.37 -5.58 -0.32 5.86e-8 Diastolic blood pressure; CESC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg13733410 chr7:12443478 VWDE -0.53 -5.45 -0.32 1.17e-7 Coronary artery disease; CESC cis rs12500824 0.536 rs4241593 chr4:77386032 G/C cg20311846 chr4:77356250 SHROOM3 -0.31 -5.62 -0.33 4.83e-8 Coronary artery disease; CESC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg18402987 chr7:1209562 NA 0.76 7.61 0.42 4.74e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg23281280 chr6:28129359 ZNF389 0.5 6.56 0.37 2.75e-10 Parkinson's disease; CESC trans rs6479874 0.598 rs2660220 chr10:52736099 G/T cg02905881 chr2:48009730 MSH6 0.78 6.0 0.35 6.46e-9 Migraine; CESC cis rs149026780 1 rs149026780 chr2:97881612 A/C cg26665480 chr2:98280029 ACTR1B -0.94 -6.87 -0.39 4.45e-11 Monocyte chemoattractant protein-3 levels; CESC cis rs10129255 0.500 rs12101190 chr14:107192386 C/T cg23076370 chr14:107095027 NA -0.65 -9.53 -0.51 1.09e-18 Kawasaki disease; CESC cis rs2274273 0.686 rs66842809 chr14:55630571 T/C cg04306507 chr14:55594613 LGALS3 0.32 5.64 0.33 4.26e-8 Protein biomarker; CESC cis rs12681366 0.537 rs10095298 chr8:95484581 G/A cg13257157 chr8:95487014 RAD54B 0.46 5.63 0.33 4.65e-8 Nonsyndromic cleft lip with cleft palate; CESC cis rs2929278 0.617 rs4617832 chr15:44030579 G/A cg27015174 chr15:43622946 ADAL;LCMT2 -0.53 -6.96 -0.39 2.68e-11 Schizophrenia; CESC cis rs4268898 0.608 rs72793980 chr2:24428859 T/C cg06627628 chr2:24431161 ITSN2 -0.84 -9.72 -0.51 2.74e-19 Asthma; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00810945 chr16:21964237 UQCRC2 0.49 6.47 0.37 4.67e-10 Gut microbiota (bacterial taxa); CESC cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg01475377 chr6:109611718 NA -0.49 -8.21 -0.45 9.56e-15 Reticulocyte fraction of red cells; CESC cis rs9902453 0.817 rs4294865 chr17:28205736 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.48 5.61 0.33 5.07e-8 Coffee consumption (cups per day); CESC cis rs1355223 0.583 rs2116085 chr11:34884001 C/A cg11058730 chr11:34937778 PDHX;APIP 0.86 13.16 0.63 9.16e-31 Systemic lupus erythematosus and Systemic sclerosis; CESC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg26338869 chr17:61819248 STRADA 0.68 8.87 0.48 1.08e-16 Prudent dietary pattern; CESC cis rs11098499 0.863 rs3822195 chr4:120471660 C/T cg09307838 chr4:120376055 NA 0.91 12.56 0.61 1.08e-28 Corneal astigmatism; CESC cis rs17376456 0.825 rs67328989 chr5:93243133 T/A cg25358565 chr5:93447407 FAM172A 1.12 10.28 0.53 4.4e-21 Diabetic retinopathy; CESC cis rs7542091 0.704 rs12022221 chr1:210046178 A/C cg09509183 chr1:209979624 IRF6 0.39 5.71 0.33 2.97e-8 Monobrow; CESC cis rs10242455 0.702 rs73401510 chr7:99065812 A/C cg18809830 chr7:99032528 PTCD1 -0.64 -5.43 -0.32 1.27e-7 Blood metabolite levels; CESC cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg15017067 chr4:17643749 FAM184B 0.41 5.94 0.34 8.84e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7845219 0.544 rs4570121 chr8:95917088 C/T cg23172400 chr8:95962367 TP53INP1 -0.39 -7.15 -0.4 8.42e-12 Type 2 diabetes; CESC cis rs9325144 0.560 rs13377717 chr12:38639474 T/A cg26384229 chr12:38710491 ALG10B -0.61 -9.62 -0.51 5.53e-19 Morning vs. evening chronotype; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg10776926 chr13:21750229 SKA3;MRP63 -0.6 -6.74 -0.38 9.69e-11 Gut microbiome composition (summer); CESC cis rs1062177 0.950 rs892005 chr5:151180621 A/G cg00977110 chr5:151150581 G3BP1 0.66 7.11 0.4 1.06e-11 Preschool internalizing problems; CESC cis rs7520050 0.966 rs12411269 chr1:46271052 C/T cg24296786 chr1:45957014 TESK2 0.43 5.41 0.32 1.38e-7 Red blood cell count;Reticulocyte count; CESC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg02018176 chr4:1364513 KIAA1530 -0.38 -5.04 -0.3 8.61e-7 Obesity-related traits; CESC cis rs1577917 0.771 rs2842601 chr6:86330133 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.54 -7.38 -0.41 1.99e-12 Response to antipsychotic treatment; CESC cis rs8114671 0.935 rs945960 chr20:33762854 A/G cg24642439 chr20:33292090 TP53INP2 0.44 5.37 0.31 1.73e-7 Height; CESC cis rs5769765 0.671 rs138833 chr22:50178917 A/G cg26441486 chr22:50317300 CRELD2 0.37 5.04 0.3 8.56e-7 Schizophrenia; CESC cis rs1144333 1.000 rs5745354 chr1:76275178 G/A cg10523679 chr1:76189770 ACADM -0.59 -5.97 -0.34 7.55e-9 Attention function in attention deficit hyperactive disorder; CESC cis rs6496667 0.542 rs58182460 chr15:90897309 A/T cg22089800 chr15:90895588 ZNF774 0.57 5.76 0.33 2.27e-8 Rheumatoid arthritis; CESC cis rs7107174 1.000 rs10501426 chr11:78057122 C/T cg02023728 chr11:77925099 USP35 0.39 5.55 0.32 7.03e-8 Testicular germ cell tumor; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16265557 chr4:8443089 ACOX3 -0.5 -6.57 -0.37 2.66e-10 Asthma; CESC cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg17366294 chr4:99064904 C4orf37 0.59 8.52 0.46 1.24e-15 Colonoscopy-negative controls vs population controls; CESC cis rs454510 0.826 rs347903 chr1:120192431 C/T cg16322792 chr1:120165303 ZNF697 0.38 5.99 0.35 6.77e-9 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CESC cis rs5167 0.645 rs1130742 chr19:45452812 C/T cg13119609 chr19:45449297 APOC2 0.38 5.22 0.31 3.56e-7 Blood protein levels; CESC cis rs3768617 0.510 rs10752902 chr1:183090265 T/A ch.1.3577855R chr1:183094577 LAMC1 0.89 14.36 0.66 5.44e-35 Fuchs's corneal dystrophy; CESC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg01570182 chr17:44337453 NA -0.66 -8.95 -0.48 6.54e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs265548 0.538 rs36688 chr19:17911212 A/C cg00024989 chr19:17902242 NA 0.47 8.16 0.45 1.39e-14 Tumor biomarkers; CESC cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg07697082 chr8:82753677 SNX16 0.41 6.22 0.36 1.92e-9 Diastolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg01591470 chr14:39736043 CTAGE5 0.61 7.35 0.41 2.42e-12 Gut microbiome composition (summer); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.48 6.66 0.38 1.54e-10 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs12410462 0.681 rs78978081 chr1:227571619 G/A cg04117972 chr1:227635322 NA 0.74 6.17 0.35 2.52e-9 Major depressive disorder; CESC cis rs644799 1.000 rs693597 chr11:95589629 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.69 8.47 0.46 1.73e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC trans rs11098499 0.909 rs1546502 chr4:120235898 A/G cg25214090 chr10:38739885 LOC399744 0.7 9.63 0.51 5.2e-19 Corneal astigmatism; CESC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg24399712 chr22:39784796 NA -0.81 -10.53 -0.54 6.85e-22 Intelligence (multi-trait analysis); CESC cis rs722599 0.748 rs17102884 chr14:75374899 C/T cg11812906 chr14:75593930 NEK9 -0.46 -5.65 -0.33 4.2e-8 IgG glycosylation; CESC trans rs7656342 0.808 rs10003216 chr4:9766749 A/G cg19546875 chr21:45432889 TRAPPC10 -0.51 -6.2 -0.36 2.16e-9 Gut microbiota (bacterial taxa); CESC trans rs6563199 0.522 rs7335775 chr13:81370189 C/T cg13867718 chr16:29973267 TMEM219 -0.48 -6.44 -0.37 5.5e-10 Height; CESC cis rs6570726 0.935 rs430561 chr6:145813140 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.77 0.38 8.09e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs7666738 0.715 rs61114099 chr4:98931270 C/T cg05340658 chr4:99064831 C4orf37 0.82 12.17 0.6 2.24e-27 Colonoscopy-negative controls vs population controls; CESC cis rs734999 0.505 rs4073286 chr1:2539901 A/C cg20673091 chr1:2541236 MMEL1 0.45 7.57 0.42 6.17e-13 Ulcerative colitis; CESC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg07677032 chr17:61819896 STRADA 0.47 6.3 0.36 1.21e-9 Prudent dietary pattern; CESC cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg03467027 chr4:99064603 C4orf37 0.46 5.82 0.34 1.74e-8 Colonoscopy-negative controls vs population controls; CESC cis rs7264396 0.676 rs1341603 chr20:34556216 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.17 -0.53 1e-20 Total cholesterol levels; CESC cis rs6570726 0.791 rs4896820 chr6:145894957 T/C cg05347473 chr6:146136440 FBXO30 0.48 6.44 0.37 5.62e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs6430585 0.528 rs721765 chr2:136748779 C/A cg07169764 chr2:136633963 MCM6 1.28 17.38 0.73 1.11e-45 Corneal structure; CESC cis rs8067354 0.527 rs1292039 chr17:57974913 A/T cg02344993 chr17:57696989 CLTC 0.54 5.57 0.32 6.18e-8 Hemoglobin concentration; CESC cis rs1707322 0.964 rs785509 chr1:46527300 G/A cg06784218 chr1:46089804 CCDC17 -0.35 -5.9 -0.34 1.11e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg06481639 chr22:41940642 POLR3H 0.61 6.24 0.36 1.72e-9 Crohn's disease;Inflammatory bowel disease; CESC trans rs17125944 0.615 rs7151643 chr14:53313661 G/C cg01134794 chr4:78529898 CXCL13 0.54 6.09 0.35 3.9e-9 Alzheimer's disease (late onset); CESC cis rs12142240 0.698 rs72886907 chr1:46814265 C/T cg10495392 chr1:46806563 NSUN4 0.57 6.21 0.36 2.02e-9 Menopause (age at onset); CESC cis rs42648 0.869 rs12704518 chr7:89914388 G/T cg23697855 chr7:89950296 NA 0.27 5.05 0.3 8.24e-7 Homocysteine levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22221222 chr6:3751199 C6orf145 0.58 7.16 0.4 8.1e-12 Gut microbiome composition (summer); CESC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg18305652 chr10:134549665 INPP5A 0.46 6.53 0.37 3.37e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg25019033 chr10:957182 NA -0.59 -6.38 -0.36 7.8e-10 Eosinophil percentage of granulocytes; CESC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg00310523 chr12:86230176 RASSF9 0.34 5.26 0.31 2.9e-7 Major depressive disorder; CESC cis rs977987 0.902 rs4888430 chr16:75494424 T/C cg03315344 chr16:75512273 CHST6 0.53 7.74 0.43 2.12e-13 Dupuytren's disease; CESC cis rs9790314 1.000 rs6775627 chr3:160953609 A/G cg03342759 chr3:160939853 NMD3 -0.46 -6.01 -0.35 5.98e-9 Morning vs. evening chronotype; CESC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg24531977 chr5:56204891 C5orf35 -0.83 -10.98 -0.56 2.32e-23 Initial pursuit acceleration; CESC cis rs72781680 0.898 rs72782137 chr2:24047805 C/T cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg12463550 chr7:65579703 CRCP 0.57 7.22 0.41 5.6e-12 Aortic root size; CESC cis rs765787 0.530 rs12917187 chr15:45538297 A/G cg24006582 chr15:45444508 DUOX1 -0.59 -7.32 -0.41 3.04e-12 Uric acid levels; CESC cis rs3126085 0.935 rs12401851 chr1:152259022 T/C cg03465714 chr1:152285911 FLG 0.5 5.98 0.34 7.27e-9 Atopic dermatitis; CESC cis rs1506636 0.962 rs2896335 chr7:123376855 A/T cg03229431 chr7:123269106 ASB15 -0.52 -6.91 -0.39 3.58e-11 Plateletcrit;Platelet count; CESC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg17971929 chr21:40555470 PSMG1 1.05 16.26 0.71 1.05e-41 Cognitive function; CESC cis rs61931739 0.500 rs9919726 chr12:34510783 A/G cg06521331 chr12:34319734 NA -0.37 -5.09 -0.3 6.85e-7 Morning vs. evening chronotype; CESC cis rs17826219 0.706 rs73271850 chr17:29142140 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.14 0.3 5.34e-7 Body mass index; CESC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg20887711 chr4:1340912 KIAA1530 0.44 5.93 0.34 9.23e-9 Longevity; CESC cis rs660498 0.581 rs616550 chr10:27740796 T/C cg25705717 chr10:27608719 NA 0.43 5.53 0.32 7.67e-8 Asthma (childhood onset); CESC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg24503407 chr1:205819492 PM20D1 0.75 11.73 0.58 7.32e-26 Menarche (age at onset); CESC cis rs601339 1.000 rs645491 chr12:123181661 T/C cg11919336 chr12:123188078 GPR109A 0.47 6.27 0.36 1.49e-9 Adiponectin levels; CESC cis rs2074585 0.806 rs2657949 chr15:90950790 G/A cg22089800 chr15:90895588 ZNF774 0.6 8.01 0.44 3.68e-14 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CESC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 7.37 0.41 2.15e-12 Tonsillectomy; CESC cis rs6963495 0.818 rs6956234 chr7:105149707 A/G cg13798780 chr7:105162888 PUS7 0.76 7.8 0.43 1.47e-13 Bipolar disorder (body mass index interaction); CESC cis rs7044106 0.762 rs1547268 chr9:123408688 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 8.63 0.47 5.83e-16 Hip circumference adjusted for BMI; CESC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg09177884 chr7:1199841 ZFAND2A -0.52 -6.84 -0.39 5.38e-11 Longevity;Endometriosis; CESC cis rs7481584 0.517 rs80872 chr11:3049984 G/T cg08508325 chr11:3079039 CARS 0.29 5.16 0.3 4.96e-7 Calcium levels; CESC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg26343298 chr8:95960752 TP53INP1 -0.36 -6.05 -0.35 5.04e-9 Type 2 diabetes; CESC cis rs873946 0.564 rs2803992 chr10:134550882 T/C cg06453172 chr10:134556979 INPP5A -0.38 -5.21 -0.3 3.74e-7 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CESC cis rs12142240 0.698 rs17361887 chr1:46834775 A/G cg10495392 chr1:46806563 NSUN4 0.57 6.01 0.35 6.05e-9 Menopause (age at onset); CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg13870041 chr1:227015885 NA -0.41 -6.16 -0.35 2.67e-9 Gambling; CESC cis rs17826219 0.636 rs12946563 chr17:29103166 C/G cg19761014 chr17:28927070 LRRC37B2 0.75 6.17 0.35 2.49e-9 Body mass index; CESC cis rs10791097 0.694 rs10791103 chr11:130757161 G/A cg12179176 chr11:130786555 SNX19 0.65 10.14 0.53 1.29e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs7714584 1.000 rs11747270 chr5:150258867 C/T cg22134413 chr5:150180641 NA -0.48 -5.42 -0.32 1.34e-7 Crohn's disease; CESC cis rs6502050 0.835 rs4789722 chr17:80151881 G/A cg23985595 chr17:80112537 CCDC57 -0.4 -6.33 -0.36 1.05e-9 Life satisfaction; CESC cis rs7818688 0.654 rs11783262 chr8:95979816 A/G cg16049864 chr8:95962084 TP53INP1 0.55 5.55 0.32 6.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CESC cis rs6582630 0.537 rs1949610 chr12:38387838 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.91 0.56 3.86e-23 Drug-induced liver injury (flucloxacillin); CESC cis rs1707322 1.000 rs11211248 chr1:46476844 A/G cg03146154 chr1:46216737 IPP 0.71 9.51 0.5 1.21e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg22823121 chr1:150693482 HORMAD1 0.37 5.16 0.3 4.89e-7 Melanoma; CESC cis rs2479106 0.892 rs2768819 chr9:126593370 A/G cg16191174 chr9:126692580 DENND1A 0.47 6.47 0.37 4.79e-10 Polycystic ovary syndrome; CESC cis rs7100689 0.784 rs4934139 chr10:82177023 C/A cg00277334 chr10:82204260 NA -0.57 -7.01 -0.4 1.94e-11 Post bronchodilator FEV1; CESC cis rs75804782 0.641 rs72987309 chr2:239348025 A/G cg18131467 chr2:239335373 ASB1 -0.67 -5.9 -0.34 1.13e-8 Morning vs. evening chronotype;Chronotype; CESC cis rs12681366 0.708 rs1011249 chr8:95438061 G/A cg13257157 chr8:95487014 RAD54B 0.38 5.19 0.3 4.26e-7 Nonsyndromic cleft lip with cleft palate; CESC cis rs17431357 0.867 rs73230314 chr12:120995953 A/G cg25045489 chr12:120971538 RNF10 -0.93 -5.46 -0.32 1.1e-7 Insulin resistance/response; CESC cis rs6691722 0.506 rs1016209 chr1:24745615 A/G cg02336364 chr1:24764700 NIPAL3 -0.31 -6.3 -0.36 1.25e-9 Response to interferon beta in multiple sclerosis; CESC trans rs561341 1.000 rs564714 chr17:30318404 C/T cg27661571 chr11:113659931 NA -0.87 -8.07 -0.44 2.48e-14 Hip circumference adjusted for BMI; CESC cis rs35110281 0.627 rs7282704 chr21:44966253 A/G cg01579765 chr21:45077557 HSF2BP -0.5 -8.22 -0.45 9.04e-15 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg08945467 chr1:58522070 DAB1 -0.66 -7.91 -0.44 7.23e-14 Gut microbiome composition (summer); CESC cis rs3784262 1.000 rs4369598 chr15:58318603 G/T cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.12 -0.3 5.89e-7 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CESC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg11494091 chr17:61959527 GH2 0.37 5.12 0.3 5.97e-7 Height; CESC cis rs929596 0.606 rs10178992 chr2:234657877 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.59 -7.32 -0.41 2.95e-12 Total bilirubin levels in HIV-1 infection; CESC cis rs6456156 0.586 rs12213683 chr6:167460718 G/A cg07741184 chr6:167504864 NA 0.35 6.0 0.35 6.57e-9 Primary biliary cholangitis; CESC cis rs708547 0.836 rs1718882 chr4:57859533 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.78 11.09 0.56 9.72e-24 Response to bleomycin (chromatid breaks); CESC cis rs9916302 0.706 rs9890198 chr17:37457480 A/C cg07936489 chr17:37558343 FBXL20 0.96 10.55 0.54 5.78e-22 Glomerular filtration rate (creatinine); CESC trans rs10743315 0.557 rs80051304 chr12:19286086 G/A cg09562322 chr12:119419143 SRRM4 -0.48 -6.27 -0.36 1.48e-9 Gut microbiota (bacterial taxa); CESC cis rs10782582 0.593 rs6675212 chr1:76230829 C/A cg22875332 chr1:76189707 ACADM -0.44 -5.23 -0.31 3.45e-7 Daytime sleep phenotypes; CESC cis rs2282802 0.685 rs7717563 chr5:139689968 A/G cg26211634 chr5:139558579 C5orf32 -0.46 -6.56 -0.37 2.73e-10 Intelligence (multi-trait analysis); CESC cis rs10838687 0.736 rs3824866 chr11:47258853 C/T cg25783544 chr11:47291846 MADD 0.56 6.49 0.37 4.09e-10 Proinsulin levels; CESC cis rs909674 0.662 rs2899318 chr22:39837625 A/G cg11247378 chr22:39784982 NA -0.61 -8.63 -0.47 5.8e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CESC cis rs9488822 0.676 rs11153593 chr6:116335131 C/A cg15226275 chr6:116381976 FRK 0.24 6.18 0.36 2.38e-9 Cholesterol, total;LDL cholesterol; CESC cis rs72781680 0.821 rs72790304 chr2:24108557 G/A cg08917208 chr2:24149416 ATAD2B 0.67 6.69 0.38 1.29e-10 Lymphocyte counts; CESC cis rs7833986 0.501 rs72653953 chr8:56970795 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.49 0.42 1.02e-12 Height; CESC cis rs2425143 0.908 rs74784474 chr20:34422464 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.68 5.87 0.34 1.27e-8 Blood protein levels; CESC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.35 -5.8 -0.34 1.85e-8 Prostate cancer (SNP x SNP interaction); CESC cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg18850127 chr7:39170497 POU6F2 0.37 5.18 0.3 4.43e-7 IgG glycosylation; CESC cis rs6499255 0.951 rs10163235 chr16:69739867 G/T cg15192750 chr16:69999425 NA 0.51 6.07 0.35 4.38e-9 IgE levels; CESC cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg25517755 chr10:38738941 LOC399744 -0.47 -6.05 -0.35 4.86e-9 Extrinsic epigenetic age acceleration; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg03258011 chr17:54857409 NA 0.48 6.13 0.35 3.24e-9 Gut microbiota (bacterial taxa); CESC trans rs61931739 0.500 rs10844734 chr12:34043083 G/A cg26384229 chr12:38710491 ALG10B 0.53 7.22 0.41 5.44e-12 Morning vs. evening chronotype; CESC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg10578991 chr7:12443926 VWDE -0.51 -5.67 -0.33 3.75e-8 Coronary artery disease; CESC cis rs2777491 0.574 rs72739644 chr15:41719706 A/G cg18705301 chr15:41695430 NDUFAF1 -1.07 -17.08 -0.72 1.34e-44 Ulcerative colitis; CESC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg14393609 chr7:65229607 NA -0.49 -6.8 -0.39 6.73e-11 Calcium levels; CESC cis rs7100689 0.646 rs10749573 chr10:82136839 T/A cg00277334 chr10:82204260 NA -0.57 -7.51 -0.42 9.08e-13 Post bronchodilator FEV1; CESC cis rs5758659 0.714 rs5758574 chr22:42481400 G/C cg19513890 chr22:42538836 CYP2D7P1 0.36 5.28 0.31 2.71e-7 Cognitive function; CESC cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg05347473 chr6:146136440 FBXO30 0.57 7.21 0.4 5.99e-12 Lobe attachment (rater-scored or self-reported); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06013127 chr17:27903940 GIT1 -0.57 -6.0 -0.35 6.6e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14450605 chr10:51572496 NCOA4 -0.67 -8.17 -0.45 1.24e-14 Gut microbiome composition (summer); CESC cis rs11792861 0.619 rs2289480 chr9:111705501 A/C cg05043794 chr9:111880884 C9orf5 -0.31 -5.65 -0.33 4.21e-8 Menarche (age at onset); CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg24367984 chr17:1945160 OVCA2;DPH1 -0.44 -6.24 -0.36 1.73e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs116095464 0.558 rs7731089 chr5:290422 A/C cg22496380 chr5:211416 CCDC127 -0.74 -8.46 -0.46 1.77e-15 Breast cancer; CESC cis rs6691722 0.503 rs6692646 chr1:24707629 C/T cg18323236 chr1:24743029 NIPAL3 0.37 5.47 0.32 1.02e-7 Response to interferon beta in multiple sclerosis; CESC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg22823121 chr1:150693482 HORMAD1 0.39 5.35 0.31 1.93e-7 Melanoma; CESC cis rs644799 1.000 rs596277 chr11:95566886 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 13.72 0.64 9.86e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs4642101 0.640 rs3901666 chr3:12824363 G/T cg24848339 chr3:12840334 CAND2 -0.38 -5.99 -0.35 6.66e-9 QRS complex (12-leadsum); CESC cis rs7662987 0.938 rs28730592 chr4:100003743 C/T cg13256891 chr4:100009986 ADH5 -0.72 -5.39 -0.31 1.52e-7 Smoking initiation; CESC cis rs939658 0.805 rs35318825 chr15:79447098 C/A cg17916960 chr15:79447300 NA -0.36 -5.72 -0.33 2.86e-8 Refractive error; CESC cis rs7937682 0.737 rs518294 chr11:111424716 A/T cg09085632 chr11:111637200 PPP2R1B -0.76 -10.13 -0.53 1.34e-20 Primary sclerosing cholangitis; CESC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg14893161 chr1:205819251 PM20D1 0.86 15.15 0.68 8.92e-38 Menarche (age at onset); CESC cis rs2952156 0.883 rs907089 chr17:37833600 C/T cg07936489 chr17:37558343 FBXL20 -0.63 -8.36 -0.46 3.48e-15 Asthma; CESC cis rs4835473 0.897 rs1545437 chr4:144617842 G/T cg25736465 chr4:144833511 NA -0.37 -5.49 -0.32 9.48e-8 Immature fraction of reticulocytes; CESC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg18876405 chr7:65276391 NA -0.7 -9.84 -0.52 1.15e-19 Calcium levels; CESC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg12463550 chr7:65579703 CRCP 0.57 7.32 0.41 2.95e-12 Aortic root size; CESC cis rs11792861 0.816 rs113624314 chr9:111689953 G/A cg05043794 chr9:111880884 C9orf5 -0.38 -6.4 -0.37 6.93e-10 Menarche (age at onset); CESC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg06481639 chr22:41940642 POLR3H -0.58 -6.15 -0.35 2.77e-9 Vitiligo; CESC cis rs11030122 0.702 rs7128762 chr11:3943277 C/G cg18678763 chr11:4115507 RRM1 -0.44 -5.89 -0.34 1.17e-8 Mean platelet volume;Platelet distribution width; CESC cis rs3859192 0.577 rs25645 chr17:38173143 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.62 9.25 0.49 7.49e-18 White blood cell count; CESC cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg15017067 chr4:17643749 FAM184B 0.43 6.11 0.35 3.45e-9 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg20607287 chr7:12443886 VWDE -0.71 -10.03 -0.52 2.84e-20 Coronary artery disease; CESC cis rs4911259 0.552 rs13037833 chr20:31459562 C/T cg13636640 chr20:31349939 DNMT3B -0.56 -7.85 -0.43 1e-13 Inflammatory bowel disease; CESC cis rs7923609 0.967 rs7095571 chr10:65150959 T/G cg01631684 chr10:65280961 REEP3 -0.41 -5.16 -0.3 4.89e-7 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg13607699 chr17:42295918 UBTF 0.57 7.4 0.41 1.78e-12 Total body bone mineral density; CESC cis rs7666738 0.581 rs34205844 chr4:98887494 C/A cg17366294 chr4:99064904 C4orf37 0.52 7.1 0.4 1.13e-11 Colonoscopy-negative controls vs population controls; CESC cis rs6842047 0.706 rs4862667 chr4:187136416 A/G cg09526685 chr4:187126073 CYP4V2 0.63 5.36 0.31 1.78e-7 Blood protein levels; CESC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.46 -5.28 -0.31 2.65e-7 Breast cancer; CESC cis rs4843747 0.749 rs13333619 chr16:88072076 C/T cg06915872 chr16:87998081 BANP 0.55 6.69 0.38 1.32e-10 Menopause (age at onset); CESC cis rs6964587 0.839 rs12536702 chr7:91471576 G/C cg17063962 chr7:91808500 NA 0.53 6.88 0.39 4.34e-11 Breast cancer; CESC cis rs1707322 0.963 rs4459051 chr1:46451203 A/G cg05343316 chr1:45956843 TESK2 0.44 5.42 0.32 1.36e-7 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg00149659 chr3:10157352 C3orf10 1.01 12.53 0.61 1.33e-28 Alzheimer's disease; CESC cis rs9457247 0.871 rs1811121 chr6:167403539 T/C cg23791538 chr6:167370224 RNASET2 -0.58 -8.28 -0.45 6.16e-15 Crohn's disease; CESC cis rs7520050 0.807 rs4274104 chr1:46217941 T/C cg24296786 chr1:45957014 TESK2 -0.46 -5.98 -0.34 7.23e-9 Red blood cell count;Reticulocyte count; CESC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.06 12.34 0.6 5.85e-28 Gut microbiome composition (summer); CESC cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg11812906 chr14:75593930 NEK9 -0.92 -16.16 -0.7 2.35e-41 Height; CESC cis rs2637266 0.655 rs846628 chr10:78538392 G/A cg18941641 chr10:78392320 NA 0.41 7.71 0.43 2.61e-13 Pulmonary function; CESC cis rs939574 1.000 rs908196 chr2:220088248 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.6 -6.08 -0.35 4.14e-9 Platelet distribution width; CESC cis rs10754283 0.967 rs4658307 chr1:90117586 G/T cg21401794 chr1:90099060 LRRC8C 0.68 9.1 0.49 2.28e-17 Amyotrophic lateral sclerosis (sporadic); CESC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg13906792 chr15:75199810 C15orf17 -0.34 -5.05 -0.3 8.42e-7 Breast cancer; CESC cis rs68170813 0.641 rs79434636 chr7:107105656 A/C cg02696742 chr7:106810147 HBP1 -0.56 -5.26 -0.31 3.03e-7 Coronary artery disease; CESC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg04170460 chr16:29985301 TAOK2 -0.5 -6.8 -0.39 6.92e-11 Age-related hearing impairment (SNP x SNP interaction); CESC cis rs2050392 0.590 rs2065723 chr10:30720462 A/T cg25182066 chr10:30743637 MAP3K8 -0.46 -6.02 -0.35 5.85e-9 Inflammatory bowel disease; CESC cis rs11625487 0.609 rs17824567 chr14:77976450 G/T cg20045696 chr14:77926864 AHSA1 0.59 5.19 0.3 4.29e-7 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CESC cis rs2115536 1.000 rs2115536 chr15:80194247 C/T cg00225070 chr15:80189496 MTHFS 0.56 8.0 0.44 4e-14 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07578976 chr6:5086036 PPP1R3G 0.45 6.51 0.37 3.65e-10 Systemic lupus erythematosus; CESC cis rs722599 0.748 rs1059326 chr14:75369385 C/T cg11812906 chr14:75593930 NEK9 -0.47 -5.69 -0.33 3.32e-8 IgG glycosylation; CESC cis rs8112211 0.911 rs2286476 chr19:38850759 G/A cg14299480 chr19:38876666 GGN -0.44 -6.02 -0.35 5.74e-9 Blood protein levels; CESC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg16325326 chr1:53192061 ZYG11B -0.71 -11.84 -0.59 3e-26 Monocyte count; CESC cis rs6570726 0.791 rs1935612 chr6:145906090 T/A cg05347473 chr6:146136440 FBXO30 0.53 6.97 0.39 2.48e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs757110 0.866 rs5213 chr11:17408404 C/T cg15432903 chr11:17409602 KCNJ11 0.69 10.05 0.53 2.49e-20 Type 2 diabetes; CESC cis rs2997447 0.761 rs17257093 chr1:26436231 C/A cg24596570 chr1:26146463 FAM54B;LOC646471 0.62 5.33 0.31 2.07e-7 QRS complex (12-leadsum); CESC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg17221315 chr6:27791827 HIST1H4J 0.44 5.31 0.31 2.27e-7 Parkinson's disease; CESC cis rs9287719 0.935 rs1309 chr2:10743546 A/G cg00105475 chr2:10696890 NA 0.39 5.64 0.33 4.44e-8 Prostate cancer; CESC cis rs1034435 0.547 rs5767174 chr22:48898857 A/G cg05992904 chr22:48892994 FAM19A5 -0.45 -6.67 -0.38 1.48e-10 Late-onset Alzheimer's disease; CESC cis rs11792861 0.926 rs72607174 chr9:111899132 A/T cg13535736 chr9:111863775 C9orf5 -0.5 -6.61 -0.38 2.12e-10 Menarche (age at onset); CESC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg24768116 chr2:27665128 KRTCAP3 -0.33 -5.99 -0.35 6.64e-9 Total body bone mineral density; CESC cis rs59698941 0.943 rs56927472 chr5:132226038 T/A cg02081065 chr5:132209139 LEAP2 -0.52 -5.11 -0.3 6.08e-7 Apolipoprotein A-IV levels; CESC cis rs3857536 0.674 rs9345798 chr6:66951331 A/G cg07460842 chr6:66804631 NA -0.42 -5.25 -0.31 3.11e-7 Blood trace element (Cu levels); CESC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg13175981 chr1:150552382 MCL1 0.44 5.3 0.31 2.38e-7 Urate levels; CESC cis rs796364 1.000 rs769950 chr2:200730028 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.89 8.76 0.47 2.4e-16 Schizophrenia; CESC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg22974920 chr21:40686053 BRWD1 -0.42 -5.23 -0.31 3.53e-7 Cognitive function; CESC cis rs4595586 0.545 rs7980848 chr12:39375166 G/C cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.42 7.85e-13 Morning vs. evening chronotype; CESC cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg23583168 chr7:148888333 NA -0.69 -9.45 -0.5 1.82e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs6840360 0.533 rs13139327 chr4:152728590 A/C cg22705602 chr4:152727874 NA -0.37 -5.07 -0.3 7.38e-7 Intelligence (multi-trait analysis); CESC trans rs1888221 0.580 rs1537017 chr9:117811315 G/C cg11017500 chr13:111290755 CARKD -0.46 -6.1 -0.35 3.69e-9 Glucose homeostasis traits; CESC cis rs9487051 0.799 rs351725 chr6:109547939 G/A cg01475377 chr6:109611718 NA -0.38 -5.7 -0.33 3.11e-8 Reticulocyte fraction of red cells; CESC cis rs7208859 0.623 rs11652631 chr17:29060766 A/G cg14008862 chr17:28927542 LRRC37B2 0.65 5.12 0.3 5.86e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC cis rs1506636 1.000 rs2402671 chr7:123355483 T/C cg03229431 chr7:123269106 ASB15 -0.52 -6.91 -0.39 3.58e-11 Plateletcrit;Platelet count; CESC cis rs2180341 1.000 rs6569486 chr6:127708424 A/C cg27446573 chr6:127587934 RNF146 1.03 14.81 0.67 1.41e-36 Breast cancer; CESC cis rs514406 0.893 rs1242315 chr1:53417181 A/G cg16325326 chr1:53192061 ZYG11B 0.91 14.92 0.68 5.92e-37 Monocyte count; CESC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg03188948 chr7:1209495 NA 0.42 5.25 0.31 3.08e-7 Longevity;Endometriosis; CESC cis rs66686620 1.000 rs6546473 chr2:69260357 C/T cg12800200 chr2:69260302 ANTXR1 0.39 5.74 0.33 2.57e-8 Breast cancer; CESC cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg22875332 chr1:76189707 ACADM 0.59 6.89 0.39 4.15e-11 Blood metabolite levels;Acylcarnitine levels; CESC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg04234412 chr22:24373322 LOC391322 -0.51 -7.24 -0.41 4.98e-12 Liver enzyme levels (gamma-glutamyl transferase); CESC trans rs9467711 0.659 rs66757203 chr6:26454956 C/T cg06606381 chr12:133084897 FBRSL1 -0.94 -6.86 -0.39 4.96e-11 Autism spectrum disorder or schizophrenia; CESC cis rs7927771 0.524 rs10742820 chr11:47781057 C/T cg20307385 chr11:47447363 PSMC3 -0.58 -8.01 -0.44 3.54e-14 Subjective well-being; CESC cis rs11969893 0.649 rs9390699 chr6:101306502 C/G cg12253828 chr6:101329408 ASCC3 0.93 8.37 0.46 3.4e-15 Economic and political preferences (immigration/crime); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00518698 chr21:35015074 ITSN1;CRYZL1 0.56 6.2 0.36 2.1e-9 Gut microbiome composition (summer); CESC cis rs7243790 1.000 rs17558111 chr18:51963953 G/A cg04730925 chr18:51795821 POLI -0.42 -5.52 -0.32 8.02e-8 Diastolic blood pressure; CESC cis rs9486719 1.000 rs12530462 chr6:97053514 C/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.73 -0.33 2.73e-8 Migraine;Coronary artery disease; CESC cis rs2629540 0.847 rs12763093 chr10:126395688 C/G cg08799069 chr10:126477246 METTL10 -0.55 -6.92 -0.39 3.35e-11 Cocaine dependence; CESC cis rs12586317 0.547 rs2038254 chr14:35462134 C/T cg05294307 chr14:35346193 BAZ1A -0.51 -5.45 -0.32 1.16e-7 Psoriasis; CESC cis rs11785400 1.000 rs6995314 chr8:143749718 A/G cg24634471 chr8:143751801 JRK -0.46 -6.07 -0.35 4.36e-9 Schizophrenia; CESC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg12419862 chr22:24373484 LOC391322 -0.98 -16.46 -0.71 2e-42 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs3091242 0.933 rs61775174 chr1:25787313 G/A cg12412775 chr1:25698385 RHCE 0.3 5.25 0.31 3.2e-7 Erythrocyte sedimentation rate; CESC cis rs6696846 0.765 rs4394715 chr1:205108393 T/G cg00857998 chr1:205179979 DSTYK 0.56 7.37 0.41 2.21e-12 Red blood cell count; CESC cis rs1506636 1.000 rs2299984 chr7:123356921 G/T cg03229431 chr7:123269106 ASB15 0.47 6.39 0.37 7.43e-10 Plateletcrit;Platelet count; CESC cis rs57502260 0.834 rs3736228 chr11:68201295 A/G cg20283391 chr11:68216788 NA 0.61 5.27 0.31 2.77e-7 Total body bone mineral density (age 45-60); CESC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg22741997 chr17:6900356 ALOX12 -0.37 -5.77 -0.33 2.25e-8 Tonsillectomy; CESC trans rs9833726 0.799 rs71318645 chr3:86137405 G/T cg10416071 chr15:75628863 COMMD4 0.59 6.12 0.35 3.37e-9 Breast cancer; CESC cis rs1372520 0.627 rs2583964 chr4:90727218 A/G cg15133208 chr4:90757351 SNCA -0.43 -5.79 -0.33 2.02e-8 Neuroticism; CESC cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg03433033 chr1:76189801 ACADM 0.69 8.27 0.45 6.34e-15 Blood metabolite levels;Acylcarnitine levels; CESC cis rs8020095 0.571 rs17248252 chr14:67562929 T/G cg19548862 chr14:67692701 FAM71D -0.47 -5.63 -0.33 4.6e-8 Depression (quantitative trait); CESC cis rs6460942 0.591 rs62448733 chr7:12350526 C/T cg02935154 chr7:12443704 VWDE -0.49 -5.06 -0.3 7.74e-7 Coronary artery disease; CESC cis rs12476592 0.602 rs2028887 chr2:63716223 A/G cg17519650 chr2:63277830 OTX1 -0.46 -5.64 -0.33 4.33e-8 Childhood ear infection; CESC cis rs1538970 0.781 rs713358 chr1:45988267 C/G cg06784218 chr1:46089804 CCDC17 0.34 5.52 0.32 7.91e-8 Platelet count; CESC cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg17366294 chr4:99064904 C4orf37 0.58 7.97 0.44 4.76e-14 Colonoscopy-negative controls vs population controls; CESC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.59 7.65 0.43 3.76e-13 Prudent dietary pattern; CESC cis rs11828289 0.660 rs76458473 chr11:23237355 T/G cg20040320 chr11:23191996 NA -0.67 -5.77 -0.33 2.23e-8 Cancer; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg22335246 chr12:120763591 PLA2G1B -0.58 -6.74 -0.38 9.6e-11 Gut microbiome composition (summer); CESC cis rs16854884 0.586 rs6782789 chr3:143746691 G/A cg01302019 chr3:143689584 C3orf58 -0.32 -5.07 -0.3 7.32e-7 Economic and political preferences (feminism/equality); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03072483 chr17:78327711 RNF213;LOC100294362 -0.63 -7.12 -0.4 1.01e-11 Gut microbiome composition (summer); CESC cis rs854765 0.655 rs4470201 chr17:17844870 G/A cg16928487 chr17:17741425 SREBF1 -0.56 -9.73 -0.51 2.53e-19 Total body bone mineral density; CESC cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg24308560 chr3:49941425 MST1R -0.63 -9.16 -0.49 1.5e-17 Intelligence (multi-trait analysis); CESC cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.49 5.41 0.32 1.43e-7 Osteoporosis; CESC cis rs7605827 0.897 rs2890488 chr2:15635439 T/A cg19274914 chr2:15703543 NA 0.37 6.64 0.38 1.76e-10 Educational attainment (years of education); CESC cis rs4595586 0.545 rs17546375 chr12:39407248 C/A cg13010199 chr12:38710504 ALG10B 0.43 5.44 0.32 1.19e-7 Morning vs. evening chronotype; CESC cis rs8092503 1.000 rs12457718 chr18:52499626 T/C cg12377874 chr18:52495404 RAB27B 0.37 6.11 0.35 3.62e-9 Childhood body mass index; CESC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg14298792 chr15:30685198 CHRFAM7A 0.46 5.49 0.32 9.17e-8 Huntington's disease progression; CESC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg17650747 chr5:1873721 NA 0.43 5.93 0.34 9.39e-9 Cardiovascular disease risk factors; CESC cis rs778371 0.676 rs2293780 chr2:233635213 T/C cg08000102 chr2:233561755 GIGYF2 0.84 14.64 0.67 5.94e-36 Schizophrenia; CESC cis rs7727544 0.684 rs2516788 chr5:131715565 G/C cg24060327 chr5:131705240 SLC22A5 0.64 8.51 0.46 1.29e-15 Blood metabolite levels; CESC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg11764359 chr7:65958608 NA 0.98 15.79 0.7 4.82e-40 Aortic root size; CESC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 9.97 0.52 4.41e-20 Prudent dietary pattern; CESC cis rs6032067 0.777 rs62208416 chr20:43803226 G/A cg10761708 chr20:43804764 PI3 0.56 6.61 0.38 2.15e-10 Blood protein levels; CESC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg01988459 chr11:68622903 NA -0.4 -5.23 -0.31 3.48e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg05313129 chr8:58192883 C8orf71 -0.48 -5.27 -0.31 2.89e-7 Developmental language disorder (linguistic errors); CESC cis rs11642862 1.000 rs112691371 chr16:30868216 C/T cg02466173 chr16:30829666 NA -0.6 -5.57 -0.32 6.36e-8 Tonsillectomy; CESC cis rs7264396 0.887 rs224419 chr20:34143092 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -6.31 -0.36 1.15e-9 Total cholesterol levels; CESC cis rs2180341 0.618 rs4502958 chr6:127593113 G/A cg27446573 chr6:127587934 RNF146 0.62 8.48 0.46 1.62e-15 Breast cancer; CESC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg02221750 chr19:17393354 ANKLE1 0.51 6.09 0.35 3.9e-9 Systemic lupus erythematosus; CESC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg17372223 chr3:52568218 NT5DC2 0.41 6.34 0.36 9.81e-10 Electroencephalogram traits; CESC cis rs6062302 0.522 rs6090476 chr20:62248001 G/A cg09650180 chr20:62225654 GMEB2 -0.82 -9.32 -0.5 4.63e-18 Glioblastoma; CESC cis rs644799 1.000 rs651445 chr11:95539122 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 6.41 0.37 6.77e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs72781680 0.898 rs10490752 chr2:24025132 C/T cg08917208 chr2:24149416 ATAD2B 0.95 8.71 0.47 3.45e-16 Lymphocyte counts; CESC cis rs76878669 0.561 rs12416747 chr11:66135614 A/G cg18002602 chr11:66138449 SLC29A2 0.4 6.68 0.38 1.42e-10 Educational attainment (years of education); CESC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg01988459 chr11:68622903 NA -0.4 -5.05 -0.3 8.4e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs13082711 0.522 rs6551192 chr3:27343376 C/T cg02860705 chr3:27208620 NA 0.39 5.21 0.3 3.83e-7 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CESC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.33 -5.42 -0.32 1.31e-7 Prostate cancer (SNP x SNP interaction); CESC cis rs61931739 0.817 rs11053071 chr12:34201400 A/G cg19457237 chr12:34500585 NA -0.38 -5.47 -0.32 1.02e-7 Morning vs. evening chronotype; CESC cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg01579765 chr21:45077557 HSF2BP -0.57 -9.91 -0.52 6.75e-20 Mean corpuscular volume; CESC cis rs698833 0.886 rs6721675 chr2:44566027 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.54 6.73 0.38 1.04e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06397424 chr16:15737279 NDE1;KIAA0430 -0.55 -6.32 -0.36 1.12e-9 Gut microbiome composition (summer); CESC cis rs11997175 0.574 rs4520125 chr8:33648628 C/T ch.8.33884649F chr8:33765107 NA 0.65 8.33 0.46 4.44e-15 Body mass index; CESC cis rs7216064 1.000 rs34872586 chr17:65863466 T/C cg07042672 chr17:66097459 LOC651250 -0.54 -5.59 -0.32 5.61e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC cis rs3106136 0.609 rs1876917 chr4:95099737 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.23 -0.36 1.8e-9 Capecitabine sensitivity; CESC cis rs3026101 0.671 rs3026144 chr17:5316680 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.41 5.27 0.31 2.84e-7 Body mass index; CESC cis rs7084402 0.967 rs1593674 chr10:60291908 A/C cg07615347 chr10:60278583 BICC1 0.6 9.41 0.5 2.54e-18 Refractive error; CESC cis rs400736 0.729 rs1546846 chr1:8004259 C/T cg25007680 chr1:8021821 PARK7 -0.56 -7.72 -0.43 2.44e-13 Response to antidepressants and depression; CESC cis rs6674176 0.561 rs7161 chr1:44438974 A/G cg12908607 chr1:44402522 ARTN 0.53 8.16 0.45 1.32e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CESC trans rs1814175 0.817 rs4084376 chr11:49831160 T/C cg03929089 chr4:120376271 NA -0.91 -15.47 -0.69 6.65e-39 Height; CESC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg05863683 chr7:1912471 MAD1L1 0.39 5.8 0.34 1.85e-8 Bipolar disorder and schizophrenia; CESC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg02071572 chr4:1403502 NA 0.37 5.48 0.32 1e-7 Longevity; CESC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg12311346 chr5:56204834 C5orf35 0.56 7.21 0.41 5.79e-12 Type 2 diabetes; CESC cis rs7923609 0.778 rs7075195 chr10:65050659 A/G cg01631684 chr10:65280961 REEP3 -0.45 -5.64 -0.33 4.38e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CESC cis rs9611565 0.918 rs6002351 chr22:41757223 C/T cg06481639 chr22:41940642 POLR3H -0.45 -5.2 -0.3 3.93e-7 Vitiligo; CESC cis rs5753037 0.543 rs140128 chr22:30150140 T/C cg01021169 chr22:30184971 ASCC2 -0.55 -7.74 -0.43 2.14e-13 Type 1 diabetes; CESC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg22029157 chr1:209979665 IRF6 0.7 9.86 0.52 9.47e-20 Cleft lip with or without cleft palate; CESC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg13607699 chr17:42295918 UBTF 0.56 7.21 0.4 5.91e-12 Total body bone mineral density; CESC cis rs116988415 0.584 rs78707026 chr14:65249283 A/G cg25083366 chr14:65239357 SPTB 0.66 5.14 0.3 5.23e-7 Daytime sleep phenotypes; CESC cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg17366294 chr4:99064904 C4orf37 0.6 8.52 0.46 1.2e-15 Colonoscopy-negative controls vs population controls; CESC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg03188948 chr7:1209495 NA 0.42 5.28 0.31 2.67e-7 Longevity;Endometriosis; CESC trans rs11098499 0.820 rs13122709 chr4:120555356 T/A cg25214090 chr10:38739885 LOC399744 0.67 9.43 0.5 2.22e-18 Corneal astigmatism; CESC cis rs7824557 0.675 rs2736265 chr8:11186674 A/G cg21775007 chr8:11205619 TDH 0.52 7.71 0.43 2.52e-13 Retinal vascular caliber; CESC cis rs7561273 0.586 rs9309225 chr2:24292863 T/C cg20701182 chr2:24300061 SF3B14 0.45 6.03 0.35 5.41e-9 Quantitative traits; CESC cis rs6141600 0.540 rs964786 chr20:34688491 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.06 -0.35 4.74e-9 Height;Hip circumference; CESC cis rs17818399 0.749 rs4142759 chr2:46783890 A/G cg06386533 chr2:46925753 SOCS5 0.48 5.25 0.31 3.06e-7 Height; CESC trans rs3780486 0.718 rs10971418 chr9:33122024 A/C cg04842962 chr6:43655489 MRPS18A -0.74 -9.19 -0.49 1.15e-17 IgG glycosylation; CESC cis rs2034088 0.833 rs7219151 chr17:440497 G/A cg13332499 chr17:408570 NA 0.5 8.84 0.48 1.38e-16 Hip circumference adjusted for BMI; CESC cis rs7726839 0.540 rs72703092 chr5:599269 G/A cg16447950 chr5:562315 NA -0.6 -6.05 -0.35 4.91e-9 Obesity-related traits; CESC cis rs7656342 0.686 rs10031303 chr4:9841690 A/T cg00071950 chr4:10020882 SLC2A9 0.41 5.68 0.33 3.62e-8 Gut microbiota (bacterial taxa); CESC cis rs11958404 0.860 rs6868830 chr5:157442187 T/C cg05962755 chr5:157440814 NA 0.62 6.66 0.38 1.57e-10 IgG glycosylation; CESC cis rs6967414 0.685 rs6944332 chr7:6758018 G/A cg09896999 chr7:6746977 ZNF12 -0.52 -6.19 -0.36 2.31e-9 Hematocrit;Hemoglobin concentration; CESC trans rs163030 0.870 rs335607 chr5:76746523 A/G cg26150533 chr8:82396069 FABP4 -0.39 -6.0 -0.35 6.54e-9 Caudate nucleus volume; CESC cis rs959260 0.920 rs4789187 chr17:73394784 A/G cg12999837 chr17:73267436 MIF4GD -0.52 -5.79 -0.34 1.98e-8 Systemic lupus erythematosus; CESC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg11890956 chr21:40555474 PSMG1 -0.95 -14.89 -0.67 7.8e-37 Cognitive function; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg21123656 chr7:99775134 STAG3;GPC2 0.55 6.02 0.35 5.92e-9 Gut microbiome composition (summer); CESC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg04267008 chr7:1944627 MAD1L1 -0.52 -6.17 -0.35 2.48e-9 Bipolar disorder and schizophrenia; CESC cis rs6460942 0.731 rs75994414 chr7:12307992 C/A cg02935154 chr7:12443704 VWDE -0.59 -5.9 -0.34 1.11e-8 Coronary artery disease; CESC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg22535103 chr8:58192502 C8orf71 -0.8 -9.04 -0.49 3.38e-17 Developmental language disorder (linguistic errors); CESC cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.39 0.31 1.57e-7 Colonoscopy-negative controls vs population controls; CESC cis rs6723226 0.698 rs13409142 chr2:32666137 C/T cg02381751 chr2:32503542 YIPF4 0.81 11.89 0.59 2.06e-26 Intelligence (multi-trait analysis); CESC cis rs3125734 0.633 rs3765002 chr10:64006124 G/T cg09941381 chr10:64027924 RTKN2 -0.31 -5.23 -0.31 3.39e-7 Rheumatoid arthritis; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg27517717 chr19:2977389 TLE6 0.6 6.89 0.39 4.04e-11 Gut microbiome composition (summer); CESC cis rs734999 0.545 rs6684865 chr1:2546229 A/G cg18854424 chr1:2615690 NA -0.35 -7.07 -0.4 1.38e-11 Ulcerative colitis; CESC cis rs10170846 0.731 rs10180632 chr2:223526384 G/A cg25565276 chr2:223520875 FARSB 0.5 6.98 0.39 2.39e-11 Schizophrenia (inflammation and infection response interaction); CESC cis rs2290405 0.527 rs4690329 chr4:931385 T/A cg04824913 chr4:887549 GAK 0.65 8.43 0.46 2.26e-15 Systemic sclerosis; CESC cis rs7786808 0.552 rs896762 chr7:158182029 A/G cg01191920 chr7:158217561 PTPRN2 0.31 5.09 0.3 6.67e-7 Obesity-related traits; CESC cis rs6439153 0.967 rs12695512 chr3:128722082 T/G cg25356066 chr3:128598488 ACAD9 0.53 6.92 0.39 3.33e-11 Pneumococcal bacteremia; CESC cis rs698833 0.638 rs698785 chr2:44744389 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.41 5.05 0.3 8.09e-7 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs4718428 0.672 rs36038499 chr7:66289615 A/G cg18252515 chr7:66147081 NA -0.47 -5.21 -0.3 3.85e-7 Corneal structure; CESC cis rs6545883 0.860 rs6749226 chr2:61509783 G/A cg15711740 chr2:61764176 XPO1 0.39 5.05 0.3 8.27e-7 Tuberculosis; CESC cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg10523679 chr1:76189770 ACADM 0.71 8.42 0.46 2.39e-15 Blood metabolite levels;Acylcarnitine levels; CESC trans rs7618501 1.000 rs4855862 chr3:49748833 C/T cg21659725 chr3:3221576 CRBN -0.82 -13.57 -0.64 3.35e-32 Intelligence (multi-trait analysis); CESC cis rs12410462 0.581 rs4329477 chr1:227552494 A/G cg23173402 chr1:227635558 NA -0.53 -5.12 -0.3 5.97e-7 Major depressive disorder; CESC cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg18180107 chr4:99064573 C4orf37 0.4 5.23 0.31 3.41e-7 Colonoscopy-negative controls vs population controls; CESC cis rs10781543 0.776 rs4378078 chr9:139375962 A/G cg14169450 chr9:139327907 INPP5E 0.52 8.0 0.44 4e-14 Monocyte percentage of white cells; CESC cis rs1707322 0.963 rs9787412 chr1:46371596 C/T cg03146154 chr1:46216737 IPP 0.71 9.86 0.52 9.69e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs11677416 0.677 rs2856840 chr2:113538604 T/A cg27083787 chr2:113543245 IL1A 0.41 5.17 0.3 4.65e-7 Response to antipsychotic treatment in schizophrenia (working memory); CESC cis rs2070433 0.539 rs56157650 chr21:47957959 T/C cg12379764 chr21:47803548 PCNT 0.65 8.45 0.46 1.9e-15 Lymphocyte counts; CESC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg19077165 chr18:44547161 KATNAL2 -0.61 -9.33 -0.5 4.26e-18 Personality dimensions; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg10341310 chr8:66582206 MTFR1 0.51 7.29 0.41 3.51e-12 Fibrinogen levels; CESC cis rs1185460 0.967 rs3825061 chr11:118944675 C/T cg23280166 chr11:118938394 VPS11 0.5 6.37 0.36 8.42e-10 Coronary artery disease; CESC cis rs10911232 0.507 rs4652769 chr1:183009196 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 13.67 0.64 1.52e-32 Hypertriglyceridemia; CESC cis rs561341 1.000 rs7214017 chr17:30332220 T/C cg19193384 chr17:30244184 NA -0.61 -6.47 -0.37 4.74e-10 Hip circumference adjusted for BMI; CESC cis rs11098499 1.000 rs10029750 chr4:120172543 A/G cg09307838 chr4:120376055 NA 0.86 11.44 0.58 6.63e-25 Corneal astigmatism; CESC cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg20503657 chr10:835505 NA 0.79 7.96 0.44 4.97e-14 Eosinophil percentage of granulocytes; CESC cis rs5758659 0.652 rs133321 chr22:42405322 A/G cg15557168 chr22:42548783 NA -0.42 -6.27 -0.36 1.48e-9 Cognitive function; CESC trans rs2727020 0.521 rs7107178 chr11:49526668 G/A cg15704280 chr7:45808275 SEPT13 0.81 9.79 0.52 1.63e-19 Coronary artery disease; CESC cis rs7188697 0.848 rs40187 chr16:58556566 T/C cg21335942 chr16:58549945 SETD6 0.47 5.49 0.32 9.38e-8 QT interval; CESC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg18446336 chr7:2847575 GNA12 0.4 6.2 0.36 2.17e-9 Height; CESC cis rs7662987 0.517 rs1377689 chr4:100021787 A/G cg12011299 chr4:100065546 ADH4 0.6 6.6 0.38 2.23e-10 Smoking initiation; CESC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg11764359 chr7:65958608 NA 0.94 14.51 0.67 1.69e-35 Aortic root size; CESC cis rs7264396 0.676 rs6058380 chr20:34552900 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.77 -10.23 -0.53 6.44e-21 Total cholesterol levels; CESC cis rs36051895 0.664 rs10117501 chr9:5094246 G/A cg02405213 chr9:5042618 JAK2 -0.49 -6.02 -0.35 5.79e-9 Pediatric autoimmune diseases; CESC cis rs7605827 0.930 rs10929373 chr2:15663317 T/C cg19274914 chr2:15703543 NA 0.32 5.72 0.33 2.84e-8 Educational attainment (years of education); CESC cis rs2204008 0.837 rs11183232 chr12:37941053 A/G cg26384229 chr12:38710491 ALG10B 0.67 9.77 0.51 1.9e-19 Bladder cancer; CESC cis rs11683229 0.704 rs35589581 chr2:63107944 T/C cg17519650 chr2:63277830 OTX1 -0.68 -5.55 -0.32 6.94e-8 Protein quantitative trait loci; CESC cis rs1348850 0.554 rs11679519 chr2:178432110 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 6.33 0.36 1.07e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg11965913 chr1:205819406 PM20D1 0.87 15.78 0.7 5.31e-40 Menarche (age at onset); CESC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg02931644 chr1:25747376 RHCE 0.42 6.91 0.39 3.7e-11 Erythrocyte sedimentation rate; CESC cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg16339924 chr4:17578868 LAP3 0.63 8.03 0.44 3.2e-14 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs61931739 0.817 rs1705754 chr12:34145569 A/G cg19457237 chr12:34500585 NA -0.37 -5.15 -0.3 5.06e-7 Morning vs. evening chronotype; CESC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg00431813 chr7:1051703 C7orf50 0.43 5.34 0.31 1.98e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs78132593 0.718 rs72702521 chr1:150650194 C/T cg04414720 chr1:150670196 GOLPH3L -0.52 -5.24 -0.31 3.31e-7 High light scatter reticulocyte count; CESC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.45 6.3 0.36 1.21e-9 Menopause (age at onset); CESC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg23758822 chr17:41437982 NA 1.01 14.72 0.67 2.92e-36 Menopause (age at onset); CESC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.15 0.3 5.1e-7 Life satisfaction; CESC cis rs9399401 0.667 rs6903424 chr6:142699948 A/C cg03128060 chr6:142623767 GPR126 0.33 5.9 0.34 1.08e-8 Chronic obstructive pulmonary disease; CESC trans rs9929218 0.954 rs57688464 chr16:68826109 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.27 -0.45 6.69e-15 Colorectal cancer; CESC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg10128416 chr1:75198403 TYW3;CRYZ 0.48 6.3 0.36 1.23e-9 Resistin levels; CESC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg13902645 chr11:5959945 NA -0.64 -9.15 -0.49 1.61e-17 DNA methylation (variation); CESC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg23758822 chr17:41437982 NA 0.95 16.4 0.71 3.22e-42 Menopause (age at onset); CESC cis rs7772486 0.817 rs9322047 chr6:146400394 G/A cg23711669 chr6:146136114 FBXO30 0.82 12.42 0.61 3.29e-28 Lobe attachment (rater-scored or self-reported); CESC cis rs7827545 1.000 rs6578238 chr8:135569490 A/C cg17885191 chr8:135476712 NA 0.45 5.83 0.34 1.62e-8 Hypertension (SNP x SNP interaction); CESC trans rs6981523 0.553 rs11783045 chr8:11056175 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -6.14 -0.35 3.02e-9 Neuroticism; CESC trans rs1814175 0.645 rs10839456 chr11:49964093 C/T cg11707556 chr5:10655725 ANKRD33B -0.41 -6.15 -0.35 2.82e-9 Height; CESC cis rs920590 0.527 rs79929516 chr8:19650050 G/C cg01411142 chr8:19674711 INTS10 0.59 5.93 0.34 9.53e-9 Acute lymphoblastic leukemia (childhood); CESC cis rs11247915 0.561 rs11583258 chr1:26624270 C/T cg04990556 chr1:26633338 UBXN11 -0.62 -6.83 -0.39 5.7e-11 Obesity-related traits; CESC cis rs2228479 0.850 rs17226428 chr16:89842884 T/A cg00800038 chr16:89945340 TCF25 -0.91 -7.57 -0.42 6.35e-13 Skin colour saturation; CESC trans rs330048 0.561 rs1825100 chr8:9146270 C/T cg15556689 chr8:8085844 FLJ10661 -0.61 -7.16 -0.4 7.77e-12 Systemic lupus erythematosus; CESC cis rs9309473 0.500 rs4852308 chr2:73834035 T/G cg20560298 chr2:73613845 ALMS1 0.48 6.83 0.39 5.88e-11 Metabolite levels; CESC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -6.56 -0.37 2.79e-10 Total body bone mineral density; CESC cis rs8008758 0.517 rs1620117 chr14:101696931 C/A cg26224664 chr14:101693935 NA -0.47 -8.69 -0.47 3.95e-16 Body mass index (alcohol intake interaction); CESC cis rs4919694 1.000 rs78214351 chr10:104822688 A/G cg04362960 chr10:104952993 NT5C2 0.79 7.08 0.4 1.27e-11 Arsenic metabolism; CESC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg07677032 chr17:61819896 STRADA 0.49 6.27 0.36 1.49e-9 Prudent dietary pattern; CESC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg24846343 chr22:24311635 DDTL 0.74 13.62 0.64 2.18e-32 Liver enzyme levels (gamma-glutamyl transferase); CESC cis rs9916302 0.706 rs6503521 chr17:37715551 A/C cg07936489 chr17:37558343 FBXL20 0.87 9.23 0.49 8.8e-18 Glomerular filtration rate (creatinine); CESC cis rs8070740 0.898 rs4605225 chr17:5324136 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.51 6.35 0.36 9.3e-10 Menopause (age at onset); CESC cis rs9359856 0.564 rs36040566 chr6:90372574 A/C cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.7 -0.33 3.12e-8 Bipolar disorder; CESC cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg08645402 chr16:4508243 NA 0.42 5.95 0.34 8.46e-9 Schizophrenia; CESC cis rs1847202 0.563 rs13095184 chr3:72951008 A/G cg10804678 chr3:72788309 NA -0.41 -5.38 -0.31 1.63e-7 Motion sickness; CESC cis rs7940866 0.838 rs1991898 chr11:130801786 C/G cg12179176 chr11:130786555 SNX19 -0.62 -9.67 -0.51 3.89e-19 Schizophrenia; CESC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg11494091 chr17:61959527 GH2 -0.79 -13.94 -0.65 1.7e-33 Prudent dietary pattern; CESC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg07507251 chr3:52567010 NT5DC2 0.33 5.67 0.33 3.7e-8 Bipolar disorder; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg19250764 chr7:66461952 TYW1;SBDS 0.55 6.42 0.37 6.25e-10 Gut microbiome composition (summer); CESC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -5.69 -0.33 3.45e-8 Tonsillectomy; CESC cis rs12458462 0.509 rs3786241 chr18:77494328 A/C cg23301140 chr18:77439876 CTDP1 0.39 5.12 0.3 5.77e-7 Monocyte count; CESC trans rs35883536 1.000 rs4907921 chr1:101128249 C/T cg16931499 chr17:42786676 DBF4B 0.41 6.01 0.35 6.07e-9 Monocyte count; CESC cis rs561341 0.941 rs112569713 chr17:30271738 C/T cg19193384 chr17:30244184 NA -0.64 -6.73 -0.38 1.07e-10 Hip circumference adjusted for BMI; CESC cis rs1832871 0.683 rs9457224 chr6:158666139 C/T cg07165851 chr6:158734300 TULP4 0.6 6.41 0.37 6.66e-10 Height; CESC cis rs4727027 0.833 rs2107846 chr7:148832774 G/A cg23158103 chr7:148848205 ZNF398 -0.43 -7.01 -0.4 1.95e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CESC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg10691866 chr7:65817282 TPST1 0.33 5.27 0.31 2.85e-7 Aortic root size; CESC cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg21573476 chr21:45109991 RRP1B -0.41 -5.72 -0.33 2.85e-8 Mean corpuscular volume; CESC cis rs28374715 0.532 rs316604 chr15:41775221 C/T cg18705301 chr15:41695430 NDUFAF1 -1.06 -17.26 -0.73 2.96e-45 Ulcerative colitis; CESC cis rs11864453 0.647 rs3852781 chr16:72123556 T/A cg16558253 chr16:72132732 DHX38 -0.55 -8.54 -0.46 1.08e-15 Fibrinogen levels; CESC cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg08564027 chr20:61660810 NA 0.9 15.37 0.69 1.54e-38 Prostate cancer (SNP x SNP interaction); CESC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg00800038 chr16:89945340 TCF25 -0.89 -7.33 -0.41 2.79e-12 Skin colour saturation; CESC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg17949981 chr6:28129498 ZNF389 0.42 5.2 0.3 3.96e-7 Parkinson's disease; CESC cis rs9614461 0.702 rs2294202 chr22:45738327 A/T cg15911859 chr22:45810043 RIBC2;SMC1B 0.64 6.93 0.39 3.2e-11 Tonsillectomy; CESC cis rs11690935 0.527 rs7586556 chr2:172901887 G/C cg13550731 chr2:172543902 DYNC1I2 0.47 6.24 0.36 1.75e-9 Schizophrenia; CESC cis rs17253792 0.822 rs10483643 chr14:56089931 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.79 5.91 0.34 1.06e-8 Putamen volume; CESC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg17427002 chr7:12443146 VWDE 0.5 5.71 0.33 2.98e-8 Coronary artery disease; CESC cis rs5758511 0.680 rs739147 chr22:42671066 T/G cg00645731 chr22:42541494 CYP2D7P1 0.58 8.7 0.47 3.59e-16 Birth weight; CESC cis rs9581857 0.547 rs9581869 chr13:28082498 G/A cg01674679 chr13:27998804 GTF3A -0.63 -5.1 -0.3 6.52e-7 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); CESC cis rs7208859 0.573 rs11656121 chr17:29214043 A/G cg19761014 chr17:28927070 LRRC37B2 0.63 5.31 0.31 2.38e-7 Mean corpuscular hemoglobin;Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg23162967 chr3:105587981 CBLB 0.58 6.57 0.37 2.6200000000000003e-10 Gut microbiome composition (summer); CESC cis rs7551222 0.752 rs885012 chr1:204544001 C/A cg20240347 chr1:204465584 NA -0.28 -5.67 -0.33 3.82e-8 Schizophrenia; CESC cis rs2304069 0.954 rs10045945 chr5:149419297 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.93 12.0 0.59 8.6e-27 HIV-1 control; CESC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg15921436 chr17:44337874 NA 0.74 8.11 0.45 1.84e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs9914988 0.943 rs9303621 chr17:27161138 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.21 -0.3 3.82e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg19163074 chr7:65112434 INTS4L2 0.42 5.25 0.31 3.16e-7 Aortic root size; CESC cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg03806693 chr22:41940476 POLR3H 1.15 14.69 0.67 3.71e-36 Vitiligo; CESC cis rs2228479 0.850 rs2302162 chr16:89845287 A/G cg14709524 chr16:89940631 TCF25 0.91 6.76 0.38 8.75e-11 Skin colour saturation; CESC cis rs9925964 0.591 rs11649653 chr16:30918487 C/G cg02466173 chr16:30829666 NA 0.36 5.5 0.32 8.78e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs397969 0.646 rs1638527 chr17:19845393 A/G cg12073167 chr17:19770448 ULK2 0.46 5.46 0.32 1.12e-7 Platelet count; CESC cis rs60012524 1 rs60012524 chr2:99559117 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -7.67 -0.43 3.25e-13 Chronic sinus infection; CESC cis rs2479724 0.846 rs2251084 chr6:41838119 T/C cg17623882 chr6:41773611 USP49 -0.41 -5.83 -0.34 1.58e-8 Menarche (age at onset); CESC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg12648201 chr2:27665141 KRTCAP3 -0.34 -6.29 -0.36 1.34e-9 Total body bone mineral density; CESC cis rs7692995 1.000 rs7695840 chr4:17962379 A/G cg08925142 chr4:18023851 LCORL -0.45 -5.13 -0.3 5.66e-7 Height; CESC cis rs1707322 0.964 rs785508 chr1:46527159 G/A cg06784218 chr1:46089804 CCDC17 -0.35 -5.9 -0.34 1.11e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs910316 0.763 rs175016 chr14:75459633 C/T cg16144293 chr14:75469539 EIF2B2 0.41 5.44 0.32 1.2e-7 Height; CESC cis rs9611565 0.506 rs1883825 chr22:41703408 A/G cg03806693 chr22:41940476 POLR3H -0.73 -8.54 -0.46 1.06e-15 Vitiligo; CESC cis rs17209837 1.000 rs45526438 chr7:87089927 G/A cg00919237 chr7:87102261 ABCB4 -0.53 -6.03 -0.35 5.36e-9 Gallbladder cancer; CESC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg02034447 chr16:89574710 SPG7 0.47 6.06 0.35 4.56e-9 Multiple myeloma (IgH translocation); CESC trans rs4674842 0.637 rs4674862 chr2:224923426 A/T cg05748497 chr7:156804268 MNX1 -0.5 -6.49 -0.37 4.28e-10 Cerebrospinal T-tau levels; CESC cis rs1062177 1.000 rs12515762 chr5:151209922 G/T cg00977110 chr5:151150581 G3BP1 0.63 6.72 0.38 1.12e-10 Preschool internalizing problems; CESC cis rs12477438 0.684 rs6756880 chr2:99676991 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.73 -0.47 2.94e-16 Chronic sinus infection; CESC cis rs6540556 0.723 rs1999826 chr1:209919275 C/T cg23920097 chr1:209922102 NA -0.38 -5.33 -0.31 2.06e-7 Red blood cell count; CESC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg05368731 chr17:41323189 NBR1 0.79 11.2 0.57 4.42e-24 Menopause (age at onset); CESC cis rs2072499 0.695 rs112223391 chr1:156156094 G/A cg24450063 chr1:156163899 SLC25A44 0.98 12.06 0.6 5.65e-27 Testicular germ cell tumor; CESC cis rs8114671 0.562 rs2076667 chr20:33506964 G/A cg24642439 chr20:33292090 TP53INP2 0.43 5.19 0.3 4.19e-7 Height; CESC cis rs3768617 0.811 rs10911232 chr1:183052533 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 8.88 0.48 1.02e-16 Fuchs's corneal dystrophy; CESC cis rs4969178 0.965 rs12450528 chr17:76395753 G/A cg20026190 chr17:76395443 PGS1 0.49 7.81 0.43 1.34e-13 HDL cholesterol levels; CESC cis rs929596 0.517 rs3806592 chr2:234625936 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.55 -7.09 -0.4 1.24e-11 Total bilirubin levels in HIV-1 infection; CESC cis rs10883723 0.810 rs10748824 chr10:104274466 T/C ch.10.2196322F chr10:104248062 ACTR1A 0.42 5.16 0.3 4.76e-7 Allergic disease (asthma, hay fever or eczema); CESC cis rs4780401 0.632 rs8055462 chr16:11834821 T/C cg01061890 chr16:11836724 TXNDC11 -0.58 -7.71 -0.43 2.6e-13 Rheumatoid arthritis; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg20546810 chr20:2489835 ZNF343 -0.52 -6.76 -0.38 8.98e-11 Fibrinogen levels; CESC cis rs7103648 0.864 rs12801188 chr11:47388214 G/A cg03711944 chr11:47377212 SPI1 -0.39 -6.09 -0.35 3.9e-9 Diastolic blood pressure;Systolic blood pressure; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg02798621 chr6:82462430 FAM46A -0.53 -6.14 -0.35 3.03e-9 Gut microbiome composition (summer); CESC cis rs6570726 0.935 rs12663204 chr6:145818373 G/A cg05347473 chr6:146136440 FBXO30 0.49 6.71 0.38 1.2e-10 Lobe attachment (rater-scored or self-reported); CESC cis rs7264396 0.563 rs6058302 chr20:34290037 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.78 -0.55 1.03e-22 Total cholesterol levels; CESC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 13.64 0.64 1.95e-32 Platelet count; CESC cis rs2108622 0.727 rs77780918 chr19:15982707 T/C cg13772218 chr19:15982569 NA 0.29 5.8 0.34 1.85e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CESC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg02725872 chr8:58115012 NA -0.42 -5.64 -0.33 4.38e-8 Developmental language disorder (linguistic errors); CESC trans rs543686 0.770 rs4923765 chr15:35052405 A/G cg09747230 chr5:43613142 NNT -0.51 -6.81 -0.39 6.44e-11 Prostate cancer (SNP x SNP interaction); CESC cis rs9611519 0.780 rs1535048 chr22:41684093 C/T cg03806693 chr22:41940476 POLR3H -0.72 -8.24 -0.45 8.26e-15 Neuroticism; CESC cis rs854765 0.583 rs8080823 chr17:17864048 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.49 6.22 0.36 1.97e-9 Total body bone mineral density; CESC cis rs7914558 1.000 rs1890184 chr10:104748459 A/C cg04362960 chr10:104952993 NT5C2 0.47 6.24 0.36 1.77e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CESC cis rs9916302 0.904 rs9898170 chr17:37510092 T/C cg20243544 chr17:37824526 PNMT -0.47 -5.74 -0.33 2.54e-8 Glomerular filtration rate (creatinine); CESC cis rs4971059 0.654 rs12028043 chr1:155132836 A/G cg22049894 chr1:155113146 DPM3 0.48 6.07 0.35 4.32e-9 Breast cancer; CESC cis rs28386778 0.700 rs12449555 chr17:62003982 T/A cg22520471 chr17:61851767 DDX42;CCDC47 -0.83 -11.64 -0.58 1.48e-25 Prudent dietary pattern; CESC cis rs9902453 0.904 rs7212292 chr17:28409264 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -8.81 -0.48 1.72e-16 Coffee consumption (cups per day); CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg14950044 chr20:49457327 BCAS4 -0.51 -6.9 -0.39 3.85e-11 Gut microbiota (bacterial taxa); CESC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg13298116 chr11:62369859 EML3;MTA2 -0.52 -7.55 -0.42 7.15e-13 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CESC cis rs684232 0.623 rs417171 chr17:576941 A/G cg12384639 chr17:618140 VPS53 0.41 5.27 0.31 2.81e-7 Prostate cancer; CESC cis rs9914988 0.943 rs7211502 chr17:27163295 C/A cg20469991 chr17:27169893 C17orf63 -0.48 -5.21 -0.3 3.82e-7 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CESC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg21248554 chr2:27665150 KRTCAP3 -0.36 -7.38 -0.41 2.02e-12 Total body bone mineral density; CESC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg24675658 chr1:53192096 ZYG11B 0.56 6.99 0.39 2.2e-11 Monocyte count; CESC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 9.72 0.51 2.66e-19 Prudent dietary pattern; CESC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg17971929 chr21:40555470 PSMG1 -0.53 -6.94 -0.39 3.08e-11 Menarche (age at onset); CESC cis rs7843479 0.930 rs2054713 chr8:21840534 A/G cg17168535 chr8:21777572 XPO7 0.52 7.25 0.41 4.55e-12 Mean corpuscular volume; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg06391762 chr17:46908391 CALCOCO2 0.57 6.57 0.37 2.71e-10 Gut microbiome composition (summer); CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg05947499 chr12:113704091 TPCN1 0.49 6.4 0.37 7.11e-10 Fibrinogen levels; CESC trans rs17039065 0.920 rs11737760 chr4:109441230 A/G cg27151770 chr16:49620536 ZNF423 -0.51 -6.21 -0.36 2.09e-9 Gut microbiome composition (summer); CESC cis rs8062405 1.000 rs62037367 chr16:28874547 C/G cg08761264 chr16:28874980 SH2B1 -0.47 -5.85 -0.34 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CESC cis rs4148883 0.628 rs34195655 chr4:100073795 C/T cg12011299 chr4:100065546 ADH4 0.67 9.97 0.52 4.3e-20 Alcohol dependence; CESC trans rs3942852 0.568 rs10838800 chr11:48094879 C/T cg15704280 chr7:45808275 SEPT13 -0.73 -9.55 -0.51 9.45e-19 Acute lymphoblastic leukemia (childhood); CESC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg24829409 chr8:58192753 C8orf71 -0.64 -7.2 -0.4 6.25e-12 Developmental language disorder (linguistic errors); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17928916 chr17:80041824 FASN -0.55 -6.23 -0.36 1.87e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00871979 chr18:11982063 IMPA2 -0.58 -6.38 -0.36 7.65e-10 Gut microbiome composition (summer); CESC cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg03433033 chr1:76189801 ACADM 0.64 7.42 0.41 1.54e-12 Blood metabolite levels;Acylcarnitine levels; CESC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg14562523 chr21:43528734 C21orf128;UMODL1 -0.45 -6.85 -0.39 5.27e-11 IgG glycosylation; CESC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg04553112 chr3:125709451 NA -0.51 -5.59 -0.33 5.51e-8 Blood pressure (smoking interaction); CESC cis rs644799 0.544 rs525087 chr11:95632266 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.51 6.73 0.38 1.03e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs7809950 0.678 rs17153981 chr7:106922106 A/G cg23024343 chr7:107201750 COG5 -0.53 -6.69 -0.38 1.3e-10 Coronary artery disease; CESC cis rs3820068 0.581 rs6692461 chr1:15928449 A/G cg16988262 chr1:15930761 NA 0.33 5.35 0.31 1.89e-7 Systolic blood pressure; CESC cis rs3747547 0.685 rs72726067 chr9:38099153 G/A cg13774184 chr9:37916125 SHB -0.61 -5.05 -0.3 8.06e-7 Metabolite levels (Dihydroxy docosatrienoic acid); CESC cis rs2299587 0.554 rs3853531 chr8:17748920 C/T cg08627089 chr8:17753878 FGL1 0.41 5.78 0.33 2.07e-8 Economic and political preferences; CESC cis rs4253772 0.872 rs45576734 chr22:46638365 A/G cg00784671 chr22:46762841 CELSR1 -0.51 -5.27 -0.31 2.87e-7 LDL cholesterol;Cholesterol, total; CESC cis rs8067545 0.532 rs56371654 chr17:19960362 G/T cg12073167 chr17:19770448 ULK2 -0.43 -5.11 -0.3 6.19e-7 Schizophrenia; CESC cis rs17826219 0.568 rs9903854 chr17:29153998 C/T cg13385521 chr17:29058706 SUZ12P 0.75 5.95 0.34 8.3e-9 Body mass index; CESC cis rs9287719 0.649 rs7589694 chr2:10700874 T/C cg00105475 chr2:10696890 NA 0.39 5.37 0.31 1.74e-7 Prostate cancer; CESC cis rs9611565 0.512 rs139571 chr22:42214238 G/A cg17376030 chr22:41985996 PMM1 0.79 8.24 0.45 7.8e-15 Vitiligo; CESC trans rs10198628 0.623 rs779339 chr2:13043884 A/G cg11288833 chr15:55489084 RSL24D1 0.45 6.33 0.36 1.03e-9 Pericardial adipose tissue adjusted for height and weight;Pericardial fat; CESC cis rs6088580 0.634 rs4277599 chr20:33008905 A/G cg06115741 chr20:33292138 TP53INP2 -0.51 -6.98 -0.39 2.43e-11 Glomerular filtration rate (creatinine); CESC cis rs1003719 0.788 rs2835592 chr21:38464387 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.63 8.77 0.47 2.14e-16 Eye color traits; CESC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs6835098 0.816 rs13111572 chr4:174159788 G/A cg08422745 chr4:174089978 GALNT7 0.77 10.33 0.54 2.99e-21 Dementia and core Alzheimer's disease neuropathologic changes; CESC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg27165867 chr14:105738592 BRF1 -0.52 -5.66 -0.33 3.92e-8 Mean platelet volume;Platelet distribution width; CESC cis rs11864453 0.647 rs3852781 chr16:72123556 T/A cg01557791 chr16:72042693 DHODH -0.43 -5.57 -0.32 6.39e-8 Fibrinogen levels; CESC cis rs2549003 0.966 rs10065633 chr5:131816716 T/C cg21138405 chr5:131827807 IRF1 0.54 9.24 0.49 8.12e-18 Asthma (sex interaction); CESC cis rs2204008 0.774 rs11495721 chr12:38337224 A/C cg13010199 chr12:38710504 ALG10B 0.45 5.79 0.34 1.95e-8 Bladder cancer; CESC cis rs11098499 0.863 rs1480939 chr4:120456927 T/C cg24375607 chr4:120327624 NA 0.43 5.21 0.3 3.82e-7 Corneal astigmatism; CESC cis rs34421088 0.678 rs35726503 chr8:11591916 A/T cg12395012 chr8:11607386 GATA4 0.39 5.78 0.33 2.05e-8 Neuroticism; CESC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg25767906 chr1:53392781 SCP2 0.42 5.73 0.33 2.66e-8 Monocyte count; CESC cis rs826838 1.000 rs826891 chr12:39100824 A/G cg26384229 chr12:38710491 ALG10B -0.62 -9.93 -0.52 5.65e-20 Heart rate; CESC cis rs8044868 0.530 rs12446480 chr16:72056757 A/G cg16558253 chr16:72132732 DHX38 -0.36 -5.48 -0.32 1.01e-7 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CESC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg03647317 chr4:187891568 NA -0.38 -5.33 -0.31 2.09e-7 Lobe attachment (rater-scored or self-reported); CESC cis rs6598163 0.700 rs12813179 chr12:132302228 C/G cg02426739 chr12:132285352 NA 0.39 5.16 0.3 4.94e-7 Migraine; CESC cis rs3892630 0.588 rs7245709 chr19:33242755 C/T cg13157960 chr19:33183277 NUDT19 0.53 5.33 0.31 2.09e-7 Red blood cell traits; CESC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg22800045 chr5:56110881 MAP3K1 0.81 9.86 0.52 9.81e-20 Initial pursuit acceleration; CESC cis rs4460629 0.742 rs4625273 chr1:155076043 C/T cg01019262 chr1:155095195 NA -0.3 -5.05 -0.3 8.42e-7 Serum magnesium levels; CESC cis rs13102973 0.965 rs28799927 chr4:135867094 A/G cg14419869 chr4:135874104 NA -0.4 -6.29 -0.36 1.32e-9 Subjective well-being; CESC cis rs9649465 1.000 rs7776792 chr7:123335350 C/T cg04330084 chr7:123175371 IQUB 0.38 5.2 0.3 4.04e-7 Migraine; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13180005 chr1:182360683 GLUL -0.52 -6.47 -0.37 4.7e-10 Ulcerative colitis; CESC trans rs7246760 0.618 rs73008109 chr19:9734056 C/T cg02900749 chr2:68251473 NA -0.8 -6.18 -0.35 2.43e-9 Pursuit maintenance gain; CESC cis rs3733585 0.648 rs7376155 chr4:9952588 C/T cg00071950 chr4:10020882 SLC2A9 -0.69 -11.34 -0.57 1.42e-24 Cleft plate (environmental tobacco smoke interaction); CESC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg18490616 chr2:88469792 THNSL2 0.56 5.38 0.31 1.64e-7 Plasma clusterin levels; CESC cis rs3008870 0.755 rs2815368 chr1:67500778 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 7.97 0.44 4.75e-14 Lymphocyte percentage of white cells; CESC cis rs11958404 0.546 rs6556332 chr5:157433684 A/G cg05962755 chr5:157440814 NA 0.39 5.69 0.33 3.39e-8 IgG glycosylation; CESC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg23131131 chr22:24373011 LOC391322 0.66 7.56 0.42 6.72e-13 Urinary 1,3-butadiene metabolite levels in smokers; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13009927 chr2:242254519 SEPT2;HDLBP 0.58 7.12 0.4 1.03e-11 Gut microbiome composition (summer); CESC cis rs3820928 0.605 rs7560867 chr2:227780945 C/A cg05526886 chr2:227700861 RHBDD1 -0.55 -7.59 -0.42 5.42e-13 Pulmonary function; CESC cis rs10078 1.000 rs10078 chr5:438102 G/T cg08916839 chr5:415575 AHRR 0.41 5.42 0.32 1.34e-7 Fat distribution (HIV); CESC cis rs2742234 0.868 rs2505512 chr10:43633596 G/A cg15436174 chr10:43711423 RASGEF1A -0.41 -5.25 -0.31 3.18e-7 Hirschsprung disease; CESC cis rs7264396 0.563 rs61191623 chr20:34219987 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.58 5.65 0.33 4.22e-8 Total cholesterol levels; CESC cis rs7772486 0.686 rs9403741 chr6:146030548 G/A cg05347473 chr6:146136440 FBXO30 -0.53 -6.99 -0.39 2.21e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs6867032 1.000 rs4975802 chr5:2019750 T/C cg26168224 chr5:2018326 NA 0.98 19.59 0.77 1.89e-53 Gut microbiome composition (winter); CESC cis rs992157 0.560 rs7605980 chr2:219100869 C/G cg20019365 chr2:219134978 PNKD;AAMP 0.54 7.05 0.4 1.53e-11 Colorectal cancer; CESC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.11 -0.3 6.21e-7 Life satisfaction; CESC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg19592336 chr6:28129416 ZNF389 0.53 6.87 0.39 4.51e-11 Parkinson's disease; CESC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg27266027 chr21:40555129 PSMG1 0.48 5.86 0.34 1.37e-8 Cognitive function; CESC cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg02079420 chr8:82753780 SNX16 0.55 8.25 0.45 7.73e-15 Diastolic blood pressure; CESC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg11859384 chr17:80120422 CCDC57 0.38 5.12 0.3 6.01e-7 Life satisfaction; CESC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg26314531 chr2:26401878 FAM59B 0.85 9.04 0.49 3.46e-17 Gut microbiome composition (summer); CESC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.51 6.47 0.37 4.8e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg12963246 chr6:28129442 ZNF389 0.35 5.04 0.3 8.58e-7 Cardiac Troponin-T levels; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg12064626 chr21:40817896 SH3BGR -0.62 -7.42 -0.41 1.62e-12 Gut microbiome composition (summer); CESC cis rs3092073 0.624 rs7275164 chr20:44604822 G/A cg17986701 chr20:44574422 PCIF1 0.35 5.06 0.3 7.82e-7 Intelligence (multi-trait analysis); CESC cis rs863345 0.933 rs2051068 chr1:158507184 A/G cg12129480 chr1:158549410 OR10X1 -0.32 -6.48 -0.37 4.43e-10 Pneumococcal bacteremia; CESC cis rs796364 0.806 rs4673634 chr2:200863349 A/C cg23649088 chr2:200775458 C2orf69 0.6 5.37 0.31 1.74e-7 Schizophrenia; CESC cis rs3780486 0.522 rs7029897 chr9:33124042 T/C cg13443165 chr9:33130375 B4GALT1 0.47 7.15 0.4 8.69e-12 IgG glycosylation; CESC trans rs61931739 0.500 rs34167298 chr12:34534338 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.84 0.55 6.43e-23 Morning vs. evening chronotype; CESC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg03806693 chr22:41940476 POLR3H -1.2 -14.88 -0.67 7.9e-37 Vitiligo; CESC trans rs9858542 0.953 rs35261698 chr3:49537839 C/G cg21659725 chr3:3221576 CRBN -0.54 -6.37 -0.36 8.2e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs3750965 0.734 rs11604251 chr11:68820429 A/G cg01403660 chr11:68851641 TPCN2 -0.39 -5.05 -0.3 8.21e-7 Hair color; CESC cis rs3008870 0.755 rs2815355 chr1:67485034 A/G cg02640540 chr1:67518911 SLC35D1 0.44 5.36 0.31 1.84e-7 Lymphocyte percentage of white cells; CESC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg00166722 chr3:10149974 C3orf24 0.55 7.09 0.4 1.21e-11 Alzheimer's disease; CESC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg15445000 chr17:37608096 MED1 0.4 6.49 0.37 4.18e-10 Glomerular filtration rate (creatinine); CESC cis rs6912958 0.781 rs13193380 chr6:88297057 G/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.58 -0.37 2.55e-10 Monocyte percentage of white cells; CESC cis rs9911578 0.967 rs8075786 chr17:56819216 T/C cg12560992 chr17:57184187 TRIM37 0.92 15.09 0.68 1.43e-37 Intelligence (multi-trait analysis); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24450312 chr1:206681158 RASSF5 0.59 6.77 0.38 8.48e-11 Gut microbiome composition (summer); CESC cis rs27434 0.583 rs28129 chr5:96155518 G/A cg16492584 chr5:96139282 ERAP1 -0.36 -5.09 -0.3 6.81e-7 Ankylosing spondylitis; CESC cis rs3096299 0.606 rs4785573 chr16:89565403 A/G cg02034447 chr16:89574710 SPG7 0.5 6.03 0.35 5.36e-9 Multiple myeloma (IgH translocation); CESC cis rs1153858 1.000 rs66939267 chr15:45676902 T/A cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs477692 0.571 rs10764890 chr10:131347163 G/A cg24747557 chr10:131355152 MGMT -0.4 -5.76 -0.33 2.28e-8 Response to temozolomide; CESC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg23708337 chr7:1209742 NA 0.52 5.16 0.3 4.88e-7 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -6.4 -0.37 7.12e-10 Electroencephalogram traits; CESC cis rs7219021 0.705 rs9904288 chr17:47031973 T/C cg16584676 chr17:46985605 UBE2Z -0.62 -7.12 -0.4 1.04e-11 Schizophrenia or bipolar disorder; CESC cis rs6088580 0.524 rs11167241 chr20:33250835 C/T cg08999081 chr20:33150536 PIGU -0.46 -6.42 -0.37 6.23e-10 Glomerular filtration rate (creatinine); CESC cis rs67311347 0.956 rs6771527 chr3:40506548 T/C cg01475735 chr3:40494733 NA 0.43 5.32 0.31 2.18e-7 Renal cell carcinoma; CESC trans rs4332037 1.000 rs6947019 chr7:1950337 G/A cg11693508 chr17:37793320 STARD3 0.68 6.53 0.37 3.39e-10 Bipolar disorder; CESC cis rs2235544 0.565 rs635045 chr1:54469109 A/G cg25741118 chr1:54482237 LDLRAD1 0.23 5.64 0.33 4.44e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs4704187 0.687 rs28376290 chr5:74454706 C/T cg03227963 chr5:74354835 NA 0.3 5.46 0.32 1.08e-7 Response to amphetamines; CESC cis rs7584330 0.518 rs6715245 chr2:238445803 C/T cg14458575 chr2:238380390 NA 0.66 6.56 0.37 2.78e-10 Prostate cancer; CESC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.61 5.99 0.35 6.71e-9 Cerebrospinal P-tau181p levels; CESC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg19680485 chr15:31195859 MTMR15 -0.43 -5.26 -0.31 3.02e-7 Huntington's disease progression; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg14802876 chr6:34217098 C6orf1 0.63 7.8 0.43 1.42e-13 Gut microbiome composition (summer); CESC cis rs4555082 0.957 rs2816609 chr14:105720803 A/C cg06808227 chr14:105710500 BRF1 -0.5 -6.3 -0.36 1.24e-9 Mean platelet volume;Platelet distribution width; CESC cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg15017067 chr4:17643749 FAM184B 0.37 5.18 0.3 4.38e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7945705 0.967 rs56316046 chr11:8876598 G/T cg21881798 chr11:8931708 C11orf17;ST5 0.48 7.65 0.43 3.67e-13 Hemoglobin concentration; CESC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg26335602 chr6:28129616 ZNF389 0.44 5.61 0.33 5.19e-8 Parkinson's disease; CESC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg14558114 chr2:88469736 THNSL2 -0.52 -7.56 -0.42 6.77e-13 Response to metformin (IC50); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03477043 chr16:2812423 SRRM2 -0.63 -7.14 -0.4 8.78e-12 Gut microbiome composition (summer); CESC cis rs3015497 0.789 rs1389652 chr14:51125240 T/C cg09863266 chr14:51125203 SAV1 -0.36 -5.66 -0.33 3.95e-8 Mean platelet volume; CESC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg24829409 chr8:58192753 C8orf71 -0.76 -10.08 -0.53 2e-20 Developmental language disorder (linguistic errors); CESC trans rs7937682 0.889 rs1784787 chr11:111486125 T/A cg18187862 chr3:45730750 SACM1L 0.48 6.01 0.35 6.26e-9 Primary sclerosing cholangitis; CESC cis rs34375054 0.660 rs900411 chr12:125612839 C/T cg25124228 chr12:125621409 AACS -0.53 -6.5 -0.37 4.05e-10 Post bronchodilator FEV1/FVC ratio; CESC cis rs9908102 0.740 rs4792310 chr17:12908734 T/A cg26162695 chr17:12921313 ELAC2 0.51 5.44 0.32 1.19e-7 Schizophrenia; CESC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 8.6 0.47 6.88e-16 Menopause (age at onset); CESC cis rs11098499 0.739 rs10013032 chr4:120149419 C/T cg09307838 chr4:120376055 NA -0.68 -8.42 -0.46 2.43e-15 Corneal astigmatism; CESC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 12.07 0.6 5.12e-27 Alzheimer's disease; CESC cis rs7385804 0.796 rs221801 chr7:100290031 C/A cg16850897 chr7:100343110 ZAN 0.51 7.07 0.4 1.39e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CESC cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg14820908 chr5:178986412 RUFY1 0.39 5.59 0.32 5.52e-8 Lung cancer; CESC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg05340658 chr4:99064831 C4orf37 0.81 11.84 0.59 2.93e-26 Colonoscopy-negative controls vs population controls; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg24323328 chr12:1099998 ERC1 0.62 7.28 0.41 3.78e-12 Gut microbiome composition (summer); CESC trans rs757081 0.643 rs665311 chr11:17206740 A/T cg00391031 chr10:72237473 KIAA1274 0.31 6.01 0.35 6.14e-9 Systolic blood pressure; CESC cis rs6500395 1.000 rs9939103 chr16:48592376 G/C cg04672837 chr16:48644449 N4BP1 0.5 6.23 0.36 1.78e-9 Response to tocilizumab in rheumatoid arthritis; CESC trans rs2727020 0.675 rs7929401 chr11:49350832 C/A cg15704280 chr7:45808275 SEPT13 -0.75 -8.67 -0.47 4.35e-16 Coronary artery disease; CESC cis rs12711979 0.740 rs6715434 chr2:3820862 T/G cg17052675 chr2:3827356 NA -0.41 -6.47 -0.37 4.74e-10 Itch intensity from mosquito bite adjusted by bite size; CESC cis rs9902453 0.845 rs58575982 chr17:28221776 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 8.14 0.45 1.59e-14 Coffee consumption (cups per day); CESC cis rs11997175 0.713 rs6997661 chr8:33638554 A/G ch.8.33884649F chr8:33765107 NA -0.56 -7.45 -0.42 1.31e-12 Body mass index; CESC cis rs9399135 0.636 rs7749106 chr6:135268142 G/A cg22676075 chr6:135203613 NA 0.46 6.39 0.37 7.62e-10 Red blood cell count; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg03517376 chr16:30389231 MYLPF 0.53 6.63 0.38 1.91e-10 Gut microbiome composition (summer); CESC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg21280719 chr6:42927975 GNMT -0.29 -6.71 -0.38 1.18e-10 Alzheimer's disease in APOE e4+ carriers; CESC cis rs1538970 0.781 rs10890330 chr1:45920406 G/A cg05343316 chr1:45956843 TESK2 0.91 12.32 0.6 7.03e-28 Platelet count; CESC cis rs644799 1.000 rs473148 chr11:95628606 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.81 11.46 0.58 5.95e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs6142102 0.625 rs7263727 chr20:32540939 T/C cg08999081 chr20:33150536 PIGU 0.34 5.12 0.3 5.84e-7 Skin pigmentation; CESC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg22823121 chr1:150693482 HORMAD1 0.48 7.14 0.4 9.03e-12 Tonsillectomy; CESC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg03576123 chr11:487126 PTDSS2 -1.12 -11.22 -0.57 3.61e-24 Body mass index; CESC cis rs9291683 0.530 rs11723591 chr4:9985398 T/A cg02734326 chr4:10020555 SLC2A9 0.48 7.09 0.4 1.18e-11 Bone mineral density; CESC cis rs1784581 0.588 rs1789986 chr6:162409978 C/T cg17173639 chr6:162384350 PARK2 -0.56 -8.48 -0.46 1.58e-15 Itch intensity from mosquito bite; CESC cis rs6963495 0.818 rs73192149 chr7:105210910 A/G cg19920283 chr7:105172520 RINT1 0.68 6.26 0.36 1.56e-9 Bipolar disorder (body mass index interaction); CESC cis rs8017423 0.791 rs7146250 chr14:90711703 A/G cg14092571 chr14:90743983 NA -0.57 -8.51 -0.46 1.28e-15 Mortality in heart failure; CESC cis rs4242434 0.857 rs11777808 chr8:22462755 A/C cg03733263 chr8:22462867 KIAA1967 0.95 16.03 0.7 6.97e-41 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CESC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg13206674 chr6:150067644 NUP43 0.42 5.93 0.34 9.66e-9 Lung cancer; CESC cis rs6456156 0.792 rs10946215 chr6:167516181 A/G cg07741184 chr6:167504864 NA -0.36 -6.23 -0.36 1.84e-9 Primary biliary cholangitis; CESC cis rs9303280 0.651 rs59716545 chr17:38031857 T/G cg19468946 chr17:37922297 IKZF3 -0.42 -5.54 -0.32 7.32e-8 Self-reported allergy; CESC cis rs858239 0.601 rs28673077 chr7:23250854 C/T cg23682824 chr7:23144976 KLHL7 0.45 5.79 0.34 2e-8 Cerebrospinal fluid biomarker levels; CESC cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg05340658 chr4:99064831 C4orf37 0.8 12.51 0.61 1.52e-28 Colonoscopy-negative controls vs population controls; CESC cis rs3749237 0.537 rs4459909 chr3:49469217 T/C cg06212747 chr3:49208901 KLHDC8B 0.52 6.99 0.39 2.26e-11 Resting heart rate; CESC cis rs7647973 1.000 rs10865956 chr3:49581559 C/A cg02487422 chr3:49467188 NICN1 0.39 5.13 0.3 5.59e-7 Menarche (age at onset); CESC cis rs9488822 0.676 rs10456902 chr6:116333742 C/G cg15226275 chr6:116381976 FRK -0.25 -6.22 -0.36 1.9e-9 Cholesterol, total;LDL cholesterol; CESC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg01988459 chr11:68622903 NA -0.39 -5.61 -0.33 5.05e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg11764359 chr7:65958608 NA 0.67 8.6 0.47 7.27e-16 Aortic root size; CESC trans rs11098499 0.863 rs12498539 chr4:120468370 C/T cg25214090 chr10:38739885 LOC399744 0.67 9.27 0.49 6.8e-18 Corneal astigmatism; CESC cis rs568617 0.953 rs583887 chr11:65644027 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.69 -7.4 -0.41 1.81e-12 Crohn's disease; CESC cis rs68170813 0.559 rs17427158 chr7:106824259 G/T cg02696742 chr7:106810147 HBP1 -0.53 -5.07 -0.3 7.37e-7 Coronary artery disease; CESC cis rs9325144 0.555 rs1843867 chr12:38703855 A/G cg26384229 chr12:38710491 ALG10B -0.59 -8.79 -0.48 1.96e-16 Morning vs. evening chronotype; CESC cis rs644799 1.000 rs586498 chr11:95537828 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.71 9.2 0.49 1.11e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CESC cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg01475377 chr6:109611718 NA -0.42 -6.4 -0.37 6.83e-10 Reticulocyte fraction of red cells; CESC cis rs4523957 0.890 rs432200 chr17:2191960 A/G cg16513277 chr17:2031491 SMG6 0.59 8.01 0.44 3.66e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CESC cis rs2274273 0.662 rs2147970 chr14:55660217 C/T cg04306507 chr14:55594613 LGALS3 0.31 5.27 0.31 2.78e-7 Protein biomarker; CESC cis rs9837602 0.507 rs1718244 chr3:99512608 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.6 -9.52 -0.5 1.15e-18 Breast cancer; CESC cis rs8077577 0.895 rs1563371 chr17:18111793 C/T cg16794390 chr17:18148240 FLII 0.41 5.64 0.33 4.37e-8 Obesity-related traits; CESC cis rs933688 1.000 rs7715402 chr5:90679504 T/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.15 15.47 0.69 6.41e-39 Smoking behavior; CESC cis rs2204008 0.543 rs2387018 chr12:38065638 C/T cg13010199 chr12:38710504 ALG10B 0.5 6.35 0.36 9.45e-10 Bladder cancer; CESC cis rs7571561 0.625 rs6712295 chr2:213275113 A/G cg20637307 chr2:213403960 ERBB4 0.48 5.34 0.31 1.96e-7 Gestational age at birth in premature rupture of membrane-initiated deliveries (maternal effect); CESC cis rs17095355 0.901 rs12569425 chr10:111758177 G/A cg00817464 chr10:111662876 XPNPEP1 -0.52 -5.99 -0.35 6.73e-9 Biliary atresia; CESC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg12288994 chr5:1860383 NA 0.4 6.65 0.38 1.68e-10 Cardiovascular disease risk factors; CESC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg12311346 chr5:56204834 C5orf35 -0.47 -5.69 -0.33 3.35e-8 Coronary artery disease; CESC cis rs10857712 0.754 rs2297033 chr10:135234848 C/T cg01444801 chr10:135216882 MTG1 -0.46 -5.24 -0.31 3.29e-7 Systemic lupus erythematosus; CESC cis rs2425143 1.000 rs78421482 chr20:34376486 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.79 -7.16 -0.4 8.09e-12 Blood protein levels; CESC cis rs2235642 0.821 rs8051895 chr16:1602811 A/G cg03715980 chr16:1756201 MAPK8IP3 0.38 5.05 0.3 8.33e-7 Coronary artery disease; CESC cis rs6496667 0.533 rs7173201 chr15:90991195 A/T cg22089800 chr15:90895588 ZNF774 0.45 5.81 0.34 1.75e-8 Rheumatoid arthritis; CESC cis rs1050631 0.592 rs1785909 chr18:33731173 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.53 7.16 0.4 7.87e-12 Esophageal squamous cell cancer (length of survival); CESC cis rs6542838 0.641 rs4850890 chr2:99535426 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -5.47 -0.32 1.02e-7 Fear of minor pain; CESC cis rs735396 1.000 rs735396 chr12:121438844 T/C cg02403541 chr12:121454288 C12orf43 0.63 9.18 0.49 1.25e-17 N-glycan levels; CESC cis rs3096299 0.935 rs3102387 chr16:89432276 A/C cg02187348 chr16:89574699 SPG7 0.54 7.09 0.4 1.21e-11 Multiple myeloma (IgH translocation); CESC cis rs916888 0.697 rs199516 chr17:44856485 C/T cg01570182 chr17:44337453 NA -0.87 -10.54 -0.54 6.18e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg16215983 chr18:44544982 KATNAL2;TCEB3CL 0.34 5.42 0.32 1.37e-7 Personality dimensions; CESC cis rs9291683 0.632 rs11734786 chr4:10041499 A/C cg00071950 chr4:10020882 SLC2A9 0.83 14.41 0.66 3.63e-35 Bone mineral density; CESC cis rs11203032 0.831 rs10887922 chr10:90930236 G/A cg16672925 chr10:90967113 CH25H 0.7 6.65 0.38 1.62e-10 Heart failure; CESC trans rs8064100 0.526 rs8045545 chr16:56730361 C/G cg03731171 chr3:149530375 RNF13 -0.45 -6.32 -0.36 1.13e-9 Gambling; CESC cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg11657440 chr19:46296263 DMWD -0.61 -7.65 -0.43 3.62e-13 Coronary artery disease; CESC cis rs2635047 0.967 rs12960444 chr18:44607314 T/C cg19077165 chr18:44547161 KATNAL2 -0.5 -6.84 -0.39 5.53e-11 Educational attainment; CESC cis rs9926296 0.632 rs7184315 chr16:89799373 C/G cg04287289 chr16:89883240 FANCA -0.64 -8.65 -0.47 4.89e-16 Vitiligo; CESC trans rs2733310 0.739 rs1012321 chr15:57146502 G/A cg13494055 chr3:59115467 NA -0.43 -6.04 -0.35 5.22e-9 Mean platelet volume; CESC cis rs72781680 1.000 rs115861480 chr2:24129464 T/A cg20701182 chr2:24300061 SF3B14 0.78 6.73 0.38 1.07e-10 Lymphocyte counts; CESC cis rs4642101 0.686 rs9822382 chr3:12828828 T/G cg05775895 chr3:12838266 CAND2 0.35 5.24 0.31 3.32e-7 QRS complex (12-leadsum); CESC trans rs17685 0.816 rs11763076 chr7:75765963 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 12.37 0.61 4.87e-28 Coffee consumption;Coffee consumption (cups per day); CESC cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg03467027 chr4:99064603 C4orf37 0.45 5.6 0.33 5.22e-8 Colonoscopy-negative controls vs population controls; CESC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg17221315 chr6:27791827 HIST1H4J 0.45 5.81 0.34 1.75e-8 Cardiac Troponin-T levels; CESC cis rs863345 0.967 rs11265023 chr1:158513048 C/T cg12129480 chr1:158549410 OR10X1 -0.33 -6.64 -0.38 1.73e-10 Pneumococcal bacteremia; CESC cis rs6496667 0.609 rs7183707 chr15:90883733 G/T cg22089800 chr15:90895588 ZNF774 0.5 6.09 0.35 4.05e-9 Rheumatoid arthritis; CESC cis rs67311347 0.868 rs10865895 chr3:40378677 C/T cg09455208 chr3:40491958 NA 0.47 8.03 0.44 3.16e-14 Renal cell carcinoma; CESC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg09323728 chr8:95962352 TP53INP1 -0.37 -7.49 -0.42 1.01e-12 Type 2 diabetes; CESC cis rs7267979 1.000 rs7268053 chr20:25328286 A/T cg08601574 chr20:25228251 PYGB -0.38 -5.51 -0.32 8.54e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs7100689 0.516 rs3862532 chr10:82015725 A/C cg09936400 chr10:82049201 MAT1A 0.35 5.2 0.3 4.01e-7 Post bronchodilator FEV1; CESC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg24250549 chr1:154909240 PMVK 0.62 8.54 0.46 1.05e-15 Prostate cancer; CESC cis rs703842 1.000 rs11172344 chr12:58193448 T/C cg00677455 chr12:58241039 CTDSP2 0.53 6.97 0.39 2.45e-11 Multiple sclerosis; CESC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.78 6.78 0.38 7.85e-11 Platelet count; CESC cis rs6060717 0.536 rs3829829 chr20:34537160 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.7 -6.39 -0.37 7.58e-10 Hip circumference adjusted for BMI; CESC cis rs3733585 0.664 rs17245436 chr4:9958169 A/G cg11266682 chr4:10021025 SLC2A9 -0.6 -11.09 -0.56 1.01e-23 Cleft plate (environmental tobacco smoke interaction); CESC cis rs660498 0.526 rs610451 chr10:27705152 A/G cg08398567 chr10:27609333 NA -0.4 -5.73 -0.33 2.76e-8 Asthma (childhood onset); CESC cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg12386194 chr3:101231763 SENP7 0.41 5.15 0.3 5e-7 Colorectal cancer; CESC cis rs7927592 0.913 rs10896330 chr11:68254998 A/G cg20283391 chr11:68216788 NA -0.51 -6.13 -0.35 3.15e-9 Total body bone mineral density; CESC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.32 5.67 0.33 3.7e-8 Bipolar disorder; CESC cis rs1707322 1.000 rs34694458 chr1:46332696 G/A cg03146154 chr1:46216737 IPP 0.74 10.2 0.53 7.96e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs66731853 0.771 rs541244 chr1:20889380 G/A cg04087271 chr1:20915334 CDA -0.53 -7.64 -0.42 4.01e-13 Mean corpuscular volume; CESC cis rs722599 0.683 rs8014695 chr14:75301617 C/G cg08847533 chr14:75593920 NEK9 0.49 6.07 0.35 4.49e-9 IgG glycosylation; CESC cis rs6695640 0.854 rs2526830 chr1:17728119 A/G cg01904812 chr1:17746340 RCC2 0.35 5.18 0.3 4.4e-7 Mean platelet volume; CESC cis rs9300255 0.510 rs1790133 chr12:123698518 T/G cg19016782 chr12:123741754 C12orf65 -0.45 -6.5 -0.37 3.9e-10 Neutrophil percentage of white cells; CESC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg09491104 chr22:46646882 C22orf40 0.59 8.96 0.48 5.79e-17 LDL cholesterol;Cholesterol, total; CESC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg13175981 chr1:150552382 MCL1 0.62 9.37 0.5 3.23e-18 Tonsillectomy; CESC cis rs4664308 0.618 rs62175487 chr2:160892521 C/T cg03641300 chr2:160917029 PLA2R1 -0.59 -8.54 -0.46 1.04e-15 Idiopathic membranous nephropathy; CESC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg27165867 chr14:105738592 BRF1 -0.53 -6.07 -0.35 4.39e-9 Mean platelet volume;Platelet distribution width; CESC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg13114125 chr14:105738426 BRF1 -0.89 -11.05 -0.56 1.31e-23 Mean platelet volume;Platelet distribution width; CESC cis rs2479724 0.870 rs3747753 chr6:41753380 G/T cg08135965 chr6:41755394 TOMM6 -0.42 -5.58 -0.32 5.93e-8 Menarche (age at onset); CESC cis rs501120 0.657 rs114070077 chr10:44742911 A/G cg09554077 chr10:44749378 NA 0.43 5.19 0.3 4.27e-7 Coronary artery disease;Coronary heart disease; CESC cis rs6499129 0.558 rs7203742 chr16:67605794 A/G cg26727032 chr16:67993705 SLC12A4 0.58 7.19 0.4 6.45e-12 Waist-to-hip ratio adjusted for body mass index; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13204435 chr8:95731830 DPY19L4 0.57 6.74 0.38 9.77e-11 Gut microbiome composition (summer); CESC trans rs1519277 1.000 rs35190664 chr2:123981189 C/T cg14726583 chr6:40310514 NA 0.62 6.04 0.35 5.08e-9 Breast cancer in childhood cancer survivors treated with less than 10 gray radiotherapy; CESC trans rs561341 0.556 rs542244 chr17:30307242 T/C cg27661571 chr11:113659931 NA -0.83 -7.73 -0.43 2.26e-13 Hip circumference adjusted for BMI; CESC cis rs80282103 0.867 rs12241632 chr10:1069070 A/T cg08668510 chr10:1095578 IDI1 0.73 6.25 0.36 1.61e-9 Glomerular filtration rate (creatinine); CESC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg21963583 chr11:68658836 MRPL21 0.37 5.25 0.31 3.15e-7 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CESC cis rs9612 1.000 rs346544 chr19:44256205 A/G cg08581076 chr19:44259116 C19orf61 0.5 6.09 0.35 3.89e-9 Exhaled nitric oxide output; CESC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg22535103 chr8:58192502 C8orf71 -1.05 -13.08 -0.63 1.68e-30 Developmental language disorder (linguistic errors); CESC cis rs2742234 0.590 rs2435377 chr10:43683600 A/G cg07801480 chr10:43725741 RASGEF1A -0.4 -5.19 -0.3 4.25e-7 Hirschsprung disease; CESC cis rs7927771 0.929 rs12787646 chr11:47669665 T/C cg18512352 chr11:47633146 NA -0.56 -8.67 -0.47 4.37e-16 Subjective well-being; CESC cis rs6591182 0.504 rs7116712 chr11:65372518 A/G cg27068330 chr11:65405492 SIPA1 -0.6 -7.49 -0.42 1.03e-12 Non-alcoholic fatty liver disease histology (lobular); CESC cis rs7264396 0.563 rs2225950 chr20:34333015 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.63 6.72 0.38 1.08e-10 Total cholesterol levels; CESC cis rs12142240 0.698 rs67276232 chr1:46825484 T/G cg00530320 chr1:46809349 NSUN4 0.6 8.01 0.44 3.73e-14 Menopause (age at onset); CESC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg18876405 chr7:65276391 NA 0.51 6.82 0.39 6.05e-11 Aortic root size; CESC cis rs798554 1.000 rs798560 chr7:2758309 A/G cg13628971 chr7:2884303 GNA12 0.57 7.33 0.41 2.71e-12 Height; CESC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg00129232 chr17:37814104 STARD3 0.53 6.84 0.39 5.58e-11 Glomerular filtration rate (creatinine); CESC cis rs7264396 0.563 rs2425100 chr20:34310115 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.89 -10.65 -0.55 2.79e-22 Total cholesterol levels; CESC cis rs72781680 0.665 rs72788298 chr2:24104293 T/C cg08917208 chr2:24149416 ATAD2B 0.6 6.04 0.35 5.06e-9 Lymphocyte counts; CESC cis rs3820928 0.967 rs4675114 chr2:227768362 C/T cg11843606 chr2:227700838 RHBDD1 -0.42 -5.62 -0.33 4.8e-8 Pulmonary function; CESC cis rs9640161 0.789 rs36035506 chr7:150057843 C/T cg21361702 chr7:150065534 REPIN1 0.61 6.72 0.38 1.13e-10 Blood protein levels;Circulating chemerin levels; CESC cis rs1878931 0.507 rs8054222 chr16:3413477 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.66 -7.9 -0.44 7.4e-14 Body mass index (adult); CESC cis rs12946454 0.696 rs4792819 chr17:43247957 A/C cg10701640 chr17:43249399 NA 0.48 8.92 0.48 7.87e-17 Systolic blood pressure; CESC cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg01475377 chr6:109611718 NA -0.51 -8.36 -0.46 3.66e-15 Reticulocyte fraction of red cells; CESC cis rs1670533 1.000 rs3816474 chr4:1050653 G/A cg04106633 chr4:1044584 NA 0.46 5.11 0.3 6.21e-7 Recombination rate (females); CESC cis rs7833790 1.000 rs28696138 chr8:82770794 G/A cg17211192 chr8:82754475 SNX16 0.7 8.32 0.46 4.71e-15 Diastolic blood pressure; CESC cis rs8028182 0.636 rs4886707 chr15:75755467 C/T cg20655648 chr15:75932815 IMP3 0.54 6.93 0.39 3.22e-11 Sudden cardiac arrest; CESC cis rs3806843 0.832 rs2531360 chr5:140116664 G/A cg16179182 chr5:140090404 VTRNA1-1 0.38 5.11 0.3 6.26e-7 Depressive symptoms (multi-trait analysis); CESC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg12564285 chr5:131593104 PDLIM4 0.39 5.8 0.34 1.84e-8 Breast cancer; CESC trans rs5758511 0.773 rs73165164 chr22:42355549 T/C cg15080870 chr19:47770746 CCDC9 0.5 6.19 0.36 2.24e-9 Birth weight; CESC cis rs2180341 0.960 rs7753913 chr6:127671296 A/G cg27446573 chr6:127587934 RNF146 1.06 15.51 0.69 4.62e-39 Breast cancer; CESC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg00166722 chr3:10149974 C3orf24 0.55 6.25 0.36 1.65e-9 Alzheimer's disease; CESC cis rs6430585 0.583 rs59243420 chr2:136584538 A/T cg07169764 chr2:136633963 MCM6 1.34 19.43 0.77 6.67e-53 Corneal structure; CESC cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg08213375 chr14:104286397 PPP1R13B 0.33 5.41 0.32 1.42e-7 Reticulocyte count; CESC cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.14 0.3 5.39e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg00310523 chr12:86230176 RASSF9 0.35 5.46 0.32 1.1e-7 Major depressive disorder; CESC cis rs910316 0.763 rs175036 chr14:75464295 C/T cg11812906 chr14:75593930 NEK9 -0.81 -13.34 -0.63 2.05e-31 Height; CESC cis rs8020095 0.571 rs28539317 chr14:67480832 G/A cg19548862 chr14:67692701 FAM71D -0.48 -5.77 -0.33 2.17e-8 Depression (quantitative trait); CESC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.4 5.42 0.32 1.32e-7 Menopause (age at onset); CESC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.77 8.7 0.47 3.66e-16 Gut microbiome composition (summer); CESC cis rs10911232 0.507 rs4369195 chr1:182996291 G/C ch.1.3577855R chr1:183094577 LAMC1 0.84 13.19 0.63 6.74e-31 Hypertriglyceridemia; CESC trans rs4927850 0.958 rs1975582 chr3:195751439 G/T cg16724585 chr3:197361211 NA -0.55 -6.94 -0.39 3.04e-11 Pancreatic cancer; CESC cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg03684893 chr10:554711 DIP2C -0.43 -6.58 -0.37 2.49e-10 Psychosis in Alzheimer's disease; CESC cis rs6460942 0.915 rs7803002 chr7:12306738 C/T cg06484146 chr7:12443880 VWDE -0.4 -5.63 -0.33 4.6e-8 Coronary artery disease; CESC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg11168104 chr5:1857477 NA -0.38 -5.54 -0.32 7.31e-8 Cardiovascular disease risk factors; CESC cis rs1153858 0.943 rs67045941 chr15:45677011 A/G cg14582100 chr15:45693742 SPATA5L1 0.42 5.95 0.34 8.38e-9 Homoarginine levels; CESC trans rs7628583 0.877 rs12494731 chr3:64082003 G/T cg18266620 chr1:110882148 RBM15 -0.59 -6.05 -0.35 5.03e-9 Parental extreme longevity (95 years and older); CESC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg02725872 chr8:58115012 NA -0.34 -5.32 -0.31 2.18e-7 Developmental language disorder (linguistic errors); CESC cis rs910316 0.737 rs175072 chr14:75502827 T/C cg15467112 chr14:75489610 MLH3 -0.33 -5.11 -0.3 6.23e-7 Height; CESC cis rs2295359 1.000 rs2295359 chr1:67635950 G/A cg03340356 chr1:67600835 NA 0.35 5.76 0.33 2.27e-8 Psoriasis; CESC cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg00409905 chr10:38381863 ZNF37A -0.48 -6.39 -0.37 7.35e-10 Extrinsic epigenetic age acceleration; CESC cis rs854765 0.822 rs1889014 chr17:17767165 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.42 -5.6 -0.33 5.26e-8 Total body bone mineral density; CESC cis rs11098499 0.954 rs6849171 chr4:120409549 G/A cg24375607 chr4:120327624 NA 0.46 5.75 0.33 2.39e-8 Corneal astigmatism; CESC cis rs2652822 0.571 rs11858666 chr15:63526239 G/C cg02713581 chr15:63449717 RPS27L 0.49 6.18 0.36 2.38e-9 Metabolic traits; CESC cis rs4654899 0.680 rs11805006 chr1:21249603 C/T cg05370193 chr1:21551575 ECE1 0.35 5.4 0.31 1.48e-7 Superior frontal gyrus grey matter volume; CESC cis rs2455799 0.573 rs2455830 chr3:15749213 C/T cg09340198 chr3:15902540 ANKRD28 -0.32 -5.11 -0.3 6.11e-7 Mean platelet volume; CESC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg02569458 chr12:86230093 RASSF9 0.5 7.74 0.43 2.17e-13 Major depressive disorder; CESC cis rs6429082 0.518 rs1812350 chr1:235659920 C/A cg26050004 chr1:235667680 B3GALNT2 0.82 12.98 0.62 3.75e-30 Adiposity; CESC trans rs7615952 0.604 rs9837847 chr3:125623919 G/A cg07211511 chr3:129823064 LOC729375 -0.88 -8.15 -0.45 1.47e-14 Blood pressure (smoking interaction); CESC cis rs17293817 0.589 rs2387656 chr10:1420571 C/T cg04271617 chr10:1416546 ADARB2 0.36 5.73 0.33 2.68e-8 Ejection fraction in Tripanosoma cruzi seropositivity; CESC cis rs561341 1.000 rs554078 chr17:30330109 A/C cg19193384 chr17:30244184 NA -0.71 -6.64 -0.38 1.73e-10 Hip circumference adjusted for BMI; CESC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg26338869 chr17:61819248 STRADA 0.7 9.28 0.5 6.1e-18 Prudent dietary pattern; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg11208313 chr17:27276484 PHF12 -0.47 -6.47 -0.37 4.83e-10 Gut microbiota (bacterial taxa); CESC cis rs11997175 1.000 rs6468200 chr8:33745191 A/T ch.8.33884649F chr8:33765107 NA 0.66 8.48 0.46 1.63e-15 Body mass index; CESC trans rs7083345 0.807 rs6602221 chr10:7029094 C/T cg00983485 chr15:31284262 MTMR10 0.5 6.42 0.37 6.3e-10 Gut microbiota (bacterial taxa); CESC cis rs4481887 1.000 rs4481887 chr1:248496863 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.57 0.37 2.64e-10 Common traits (Other); CESC cis rs3008870 0.959 rs2985816 chr1:67387750 G/T cg02640540 chr1:67518911 SLC35D1 0.48 5.19 0.3 4.09e-7 Lymphocyte percentage of white cells; CESC cis rs56346965 0.506 rs2159818 chr2:191532789 A/G cg10560079 chr2:191398806 TMEM194B -0.48 -5.96 -0.34 8.17e-9 Bone mineral density (Ward's triangle area); CESC cis rs9660992 0.710 rs1172136 chr1:205247097 T/G cg21643547 chr1:205240462 TMCC2 -0.46 -6.16 -0.35 2.67e-9 Mean corpuscular volume;Mean platelet volume; CESC cis rs12220238 1.000 rs10824106 chr10:75958408 C/T cg19889307 chr10:75911429 ADK;AP3M1 -0.61 -5.18 -0.3 4.48e-7 Soluble interleukin-2 receptor subunit alpha; CESC cis rs74181299 0.750 rs13421845 chr2:65336033 G/A cg05010058 chr2:65284262 CEP68 -0.31 -5.15 -0.3 5.18e-7 Pulse pressure; CESC cis rs7605827 0.930 rs6431706 chr2:15600019 C/T cg19274914 chr2:15703543 NA 0.32 5.65 0.33 4.03e-8 Educational attainment (years of education); CESC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg24818145 chr4:99064322 C4orf37 0.38 5.04 0.3 8.49e-7 Colonoscopy-negative controls vs population controls; CESC cis rs1568889 1.000 rs61889054 chr11:28333000 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 9.64 0.51 4.9e-19 Bipolar disorder; CESC cis rs4319547 0.737 rs10846920 chr12:122943231 C/T cg05707623 chr12:122985044 ZCCHC8 -0.49 -6.15 -0.35 2.82e-9 Body mass index; CESC cis rs698833 0.926 rs786419 chr2:44685153 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.46 5.8 0.34 1.89e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CESC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg21144161 chr5:423903 AHRR 0.37 6.09 0.35 3.9e-9 Cystic fibrosis severity; CESC cis rs6433857 0.594 rs1950029 chr2:181520566 G/C cg23363182 chr2:181467187 NA -0.46 -6.35 -0.36 9.29e-10 Body mass index; CESC cis rs7044106 0.708 rs1324472 chr9:123375110 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.53 0.46 1.16e-15 Hip circumference adjusted for BMI; CESC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg15921436 chr17:44337874 NA -0.48 -6.0 -0.35 6.6e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg08548086 chr5:73980929 HEXB -0.5 -6.17 -0.35 2.54e-9 Asthma; CESC cis rs4568518 0.530 rs6970593 chr7:17989359 A/G cg03009463 chr7:17980271 SNX13 -0.39 -5.19 -0.3 4.23e-7 Measles; CESC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg16278512 chr7:12443529 VWDE -0.56 -5.96 -0.34 8.1e-9 Coronary artery disease; CESC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg18099408 chr3:52552593 STAB1 -0.32 -5.2 -0.3 4.02e-7 Bipolar disorder; CESC cis rs7635838 0.892 rs9310383 chr3:11491305 A/G cg00170343 chr3:11313890 ATG7 -0.46 -6.32 -0.36 1.07e-9 HDL cholesterol; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04712435 chr14:90863145 CALM1 0.66 7.87 0.44 9.2e-14 Gut microbiome composition (summer); CESC cis rs2797160 0.967 rs984041 chr6:126021328 A/T cg05901451 chr6:126070800 HEY2 0.44 6.41 0.37 6.53e-10 Endometrial cancer; CESC cis rs1499614 1.000 rs2707828 chr7:66171377 G/A cg18252515 chr7:66147081 NA -1.42 -14.62 -0.67 6.69e-36 Gout; CESC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg00339695 chr16:24857497 SLC5A11 -0.53 -6.58 -0.37 2.56e-10 Intelligence (multi-trait analysis); CESC cis rs9875589 0.957 rs4407395 chr3:13951673 A/G cg19554555 chr3:13937349 NA 0.52 6.52 0.37 3.48e-10 Ovarian reserve; CESC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.35 -0.31 1.9e-7 Lung cancer; CESC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg19257562 chr1:2043853 PRKCZ 0.35 5.82 0.34 1.73e-8 Height; CESC cis rs2235544 0.565 rs676562 chr1:54468638 C/G cg25741118 chr1:54482237 LDLRAD1 0.24 5.77 0.33 2.2e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CESC cis rs933688 0.938 rs1477348 chr5:90707823 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 1.11 12.45 0.61 2.47e-28 Smoking behavior; CESC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg22903471 chr2:27725779 GCKR -0.52 -7.39 -0.41 1.88e-12 Total body bone mineral density; CESC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg05861140 chr6:150128134 PCMT1 -0.38 -5.43 -0.32 1.29e-7 Lung cancer; CESC cis rs4901869 0.966 rs4901870 chr14:59334221 A/T cg02291164 chr14:59296302 NA -0.44 -7.36 -0.41 2.32e-12 Panic disorder; CESC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg14926445 chr8:58193284 C8orf71 -0.54 -5.1 -0.3 6.45e-7 Developmental language disorder (linguistic errors); CESC cis rs9899728 0.539 rs57813751 chr17:73053512 C/T cg27626185 chr17:73056755 KCTD2 -0.95 -8.43 -0.46 2.23e-15 Alzheimer's disease or small vessel stroke; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg18797053 chr2:220143977 DNAJB2 0.46 6.19 0.36 2.29e-9 Systemic lupus erythematosus; CESC cis rs826838 0.967 rs826876 chr12:39123843 T/C cg13010199 chr12:38710504 ALG10B -0.46 -6.44 -0.37 5.5e-10 Heart rate; CESC cis rs9354308 0.899 rs2802056 chr6:66546219 C/A cg07460842 chr6:66804631 NA 0.58 6.53 0.37 3.29e-10 Metabolite levels; CESC trans rs6087990 0.806 rs4911259 chr20:31376282 A/C cg17548406 chr8:17104535 VPS37A;CNOT7 -0.51 -6.23 -0.36 1.8e-9 Ulcerative colitis; CESC cis rs589448 0.933 rs523398 chr12:69752775 C/T cg20891283 chr12:69753455 YEATS4 0.99 17.16 0.73 6.54e-45 Cerebrospinal fluid biomarker levels; CESC cis rs9457247 0.534 rs4710154 chr6:167394634 A/T cg25258033 chr6:167368657 RNASET2 -0.36 -5.2 -0.3 3.89e-7 Crohn's disease; CESC cis rs10463316 0.894 rs3846711 chr5:150740749 A/G cg03212797 chr5:150827313 SLC36A1 -0.48 -6.07 -0.35 4.52e-9 Metabolite levels (Pyroglutamine); CESC cis rs7777484 0.534 rs2533886 chr7:2834869 C/T cg18446336 chr7:2847575 GNA12 -0.39 -6.5 -0.37 3.87e-10 Height; CESC cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg03467027 chr4:99064603 C4orf37 0.46 5.83 0.34 1.62e-8 Colonoscopy-negative controls vs population controls; CESC cis rs9309473 0.607 rs7573719 chr2:73582986 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.22 -0.36 1.92e-9 Metabolite levels; CESC cis rs751728 0.638 rs4713686 chr6:33787506 C/T cg25922239 chr6:33757077 LEMD2 0.39 5.15 0.3 5.13e-7 Crohn's disease; CESC cis rs3749237 0.576 rs3877784 chr3:49539417 C/T cg02487422 chr3:49467188 NICN1 0.56 8.19 0.45 1.09e-14 Resting heart rate; CESC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg23161317 chr6:28129485 ZNF389 0.5 6.24 0.36 1.75e-9 Parkinson's disease; CESC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.18 -0.3 4.42e-7 Life satisfaction; CESC cis rs9858542 1.000 rs11709525 chr3:49690496 C/T cg07274523 chr3:49395745 GPX1 0.67 8.51 0.46 1.29e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CESC cis rs6088590 0.965 rs6087619 chr20:33288511 C/G cg24642439 chr20:33292090 TP53INP2 0.84 12.0 0.59 8.84e-27 Coronary artery disease; CESC cis rs10463316 0.894 rs6579866 chr5:150762524 A/G cg03212797 chr5:150827313 SLC36A1 -0.46 -6.02 -0.35 5.83e-9 Metabolite levels (Pyroglutamine); CESC cis rs7809950 0.911 rs7778250 chr7:107224565 C/A cg23024343 chr7:107201750 COG5 0.44 5.89 0.34 1.19e-8 Coronary artery disease; CESC cis rs2549003 1.000 rs6873426 chr5:131818631 G/T cg00255919 chr5:131827918 IRF1 0.51 8.62 0.47 6.06e-16 Asthma (sex interaction); CESC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -6.78 -0.38 7.82e-11 Bipolar disorder; CESC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg17372223 chr3:52568218 NT5DC2 -0.41 -6.12 -0.35 3.42e-9 Bipolar disorder; CESC cis rs501120 0.929 rs528668 chr10:44762584 G/A cg09554077 chr10:44749378 NA 0.52 6.89 0.39 4.1e-11 Coronary artery disease;Coronary heart disease; CESC cis rs3820068 0.705 rs1800616 chr1:15832229 G/A cg17385448 chr1:15911702 AGMAT 0.38 5.9 0.34 1.1e-8 Systolic blood pressure; CESC cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg03433033 chr1:76189801 ACADM 0.63 6.16 0.35 2.73e-9 Blood metabolite levels;Acylcarnitine levels; CESC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg04414720 chr1:150670196 GOLPH3L 0.51 6.76 0.38 8.61e-11 Melanoma; CESC cis rs1153858 1.000 rs12594857 chr15:45667178 A/G cg21132104 chr15:45694354 SPATA5L1 0.86 11.62 0.58 1.67e-25 Homoarginine levels; CESC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg05340658 chr4:99064831 C4orf37 0.82 12.88 0.62 8.44e-30 Colonoscopy-negative controls vs population controls; CESC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23839556 chr1:53905233 FLJ40434 -0.39 -6.04 -0.35 5.21e-9 Asthma; CESC cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg11502198 chr6:26597334 ABT1 -0.51 -5.16 -0.3 4.89e-7 Intelligence (multi-trait analysis); CESC cis rs3806843 0.933 rs2337987 chr5:140188383 T/G cg16179182 chr5:140090404 VTRNA1-1 -0.4 -5.11 -0.3 6.12e-7 Depressive symptoms (multi-trait analysis); CESC cis rs2592394 0.675 rs711827 chr2:176999120 G/A cg13092806 chr2:177043255 NA 0.52 5.85 0.34 1.43e-8 Magnesium levels;Peripheral arterial disease (traffic-related air pollution interaction); CESC cis rs4144743 0.941 rs7222617 chr17:45324080 G/T cg18085866 chr17:45331354 ITGB3 -0.66 -7.64 -0.43 3.87e-13 Body mass index; CESC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg11890956 chr21:40555474 PSMG1 1.13 19.25 0.76 2.85e-52 Cognitive function; CESC cis rs10751667 0.666 rs6597960 chr11:977036 C/T cg20946044 chr11:1010712 AP2A2 -0.39 -5.4 -0.31 1.48e-7 Alzheimer's disease (late onset); CESC cis rs10504229 0.834 rs7015674 chr8:58153166 C/T cg02725872 chr8:58115012 NA -0.37 -5.83 -0.34 1.6e-8 Developmental language disorder (linguistic errors); CESC trans rs35110281 0.693 rs4819290 chr21:45122713 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 6.06 0.35 4.66e-9 Mean corpuscular volume; CESC trans rs1814175 0.935 rs11040463 chr11:49685574 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -17.76 -0.74 4.96e-47 Height; CESC cis rs2952156 0.876 rs2313171 chr17:37833842 T/C cg20243544 chr17:37824526 PNMT 0.63 8.34 0.46 3.98e-15 Asthma; CESC cis rs12410462 0.681 rs58496521 chr1:227582375 T/C cg04117972 chr1:227635322 NA 0.71 6.16 0.35 2.66e-9 Major depressive disorder; CESC cis rs1668873 0.562 rs10157145 chr1:205261963 T/C cg21643547 chr1:205240462 TMCC2 0.35 5.16 0.3 4.94e-7 Mean platelet volume; CESC cis rs4919694 1.000 rs12253284 chr10:104665145 G/C cg04362960 chr10:104952993 NT5C2 0.74 6.43 0.37 5.8e-10 Arsenic metabolism; CESC cis rs2730245 0.528 rs1188954 chr7:158691417 G/A cg01943577 chr7:158741284 NA -0.45 -5.96 -0.34 8.09e-9 Height; CESC cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg16386425 chr10:429943 DIP2C 0.5 6.44 0.37 5.46e-10 Psychosis in Alzheimer's disease; CESC cis rs2072499 0.966 rs6427307 chr1:156190083 A/G cg24450063 chr1:156163899 SLC25A44 1.06 20.29 0.78 7.01e-56 Testicular germ cell tumor; CESC cis rs9612 1.000 rs9612 chr19:44235517 A/G cg08581076 chr19:44259116 C19orf61 0.52 5.88 0.34 1.25e-8 Exhaled nitric oxide output; CESC cis rs7474896 0.537 rs2505255 chr10:38359642 C/A cg25427524 chr10:38739819 LOC399744 -0.46 -5.32 -0.31 2.16e-7 Obesity (extreme); CESC cis rs1728785 0.818 rs1728769 chr16:68564186 C/T cg02972257 chr16:68554789 NA -0.55 -6.37 -0.36 8.21e-10 Ulcerative colitis; CESC cis rs76878669 0.561 rs7107191 chr11:66140397 G/A cg18002602 chr11:66138449 SLC29A2 0.4 6.66 0.38 1.58e-10 Educational attainment (years of education); CESC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg05863683 chr7:1912471 MAD1L1 0.5 7.62 0.42 4.53e-13 Bipolar disorder and schizophrenia; CESC cis rs9389248 0.708 rs7750574 chr6:135350932 G/C cg24558204 chr6:135376177 HBS1L 0.7 10.0 0.52 3.43e-20 High light scatter reticulocyte percentage of red cells; CESC cis rs2832191 0.740 rs2853830 chr21:30416824 A/G cg08807101 chr21:30365312 RNF160 0.97 15.17 0.68 7.53e-38 Dental caries; CESC cis rs6728642 1.000 rs57035274 chr2:97608124 C/A cg26665480 chr2:98280029 ACTR1B -0.64 -6.4 -0.37 7.17e-10 Bipolar disorder lithium response (continuous) or schizophrenia; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg15531788 chr10:38146671 ZNF248 0.59 6.66 0.38 1.55e-10 Gut microbiome composition (summer); CESC cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 8.34 0.46 4.2e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CESC cis rs6493487 0.512 rs71471587 chr15:51281623 G/T cg02338191 chr15:51200825 AP4E1 0.61 5.58 0.32 6.04e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CESC cis rs10754283 0.934 rs6684676 chr1:90102173 C/T cg21401794 chr1:90099060 LRRC8C 0.7 9.41 0.5 2.54e-18 Amyotrophic lateral sclerosis (sporadic); CESC cis rs2933343 0.700 rs2624910 chr3:128650275 G/C cg25356066 chr3:128598488 ACAD9 0.61 8.58 0.47 8.13e-16 IgG glycosylation; CESC cis rs2290720 0.896 rs6538983 chr12:101721860 T/C cg22051763 chr12:101673672 UTP20 -0.49 -6.02 -0.35 5.86e-9 Brain structure (hippocampal volume); CESC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg17724175 chr1:150552817 MCL1 0.38 5.93 0.34 9.31e-9 Melanoma; CESC cis rs10178094 1.000 rs10208158 chr2:161331081 C/T cg03641300 chr2:160917029 PLA2R1 0.38 5.39 0.31 1.55e-7 White blood cell count; CESC cis rs6696846 0.791 rs10158848 chr1:205061192 C/T cg00857998 chr1:205179979 DSTYK 0.57 7.5 0.42 9.67e-13 Red blood cell count; CESC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.2 -0.4 6.31e-12 Developmental language disorder (linguistic errors); CESC cis rs6580649 0.941 rs72644844 chr12:48465425 A/C cg24011408 chr12:48396354 COL2A1 -0.41 -5.27 -0.31 2.86e-7 Lung cancer; CESC cis rs1190552 0.841 rs56144019 chr14:102949731 G/A cg18135206 chr14:102964638 TECPR2 0.42 5.26 0.31 3e-7 Blood protein levels; CESC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg11644478 chr21:40555479 PSMG1 1.01 16.05 0.7 5.64e-41 Cognitive function; CESC cis rs7927771 0.832 rs935914 chr11:47387599 C/T cg05585544 chr11:47624801 NA 0.48 7.09 0.4 1.24e-11 Subjective well-being; CESC cis rs1552244 0.882 rs13100734 chr3:10022878 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.6 -0.51 6.32e-19 Alzheimer's disease; CESC trans rs561341 1.000 rs510264 chr17:30323414 A/G cg27661571 chr11:113659931 NA -0.87 -8.07 -0.44 2.48e-14 Hip circumference adjusted for BMI; CESC cis rs2742234 0.541 rs10793426 chr10:43745280 G/A cg07801480 chr10:43725741 RASGEF1A -0.41 -5.22 -0.31 3.61e-7 Hirschsprung disease; CESC cis rs4253772 0.591 rs6008362 chr22:46652737 G/A cg09491104 chr22:46646882 C22orf40 -0.6 -9.19 -0.49 1.18e-17 LDL cholesterol;Cholesterol, total; CESC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg10896456 chr17:42255109 ASB16;C17orf65 0.47 6.96 0.39 2.68e-11 Total body bone mineral density; CESC cis rs1559088 0.545 rs7257431 chr19:33566924 A/G cg03563238 chr19:33554763 RHPN2 -0.32 -5.84 -0.34 1.5e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CESC trans rs9929218 0.954 rs34097984 chr16:68824148 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.62 -8.14 -0.45 1.51e-14 Colorectal cancer; CESC cis rs4664308 0.618 rs66484345 chr2:160894930 C/T cg03641300 chr2:160917029 PLA2R1 -0.59 -8.49 -0.46 1.46e-15 Idiopathic membranous nephropathy; CESC cis rs7917772 0.503 rs11191347 chr10:104351617 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.53 7.51 0.42 8.92e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CESC cis rs2456568 0.570 rs1827932 chr11:93663319 A/T cg26875233 chr11:93583750 C11orf90 -0.32 -5.82 -0.34 1.69e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CESC cis rs4862750 0.872 rs13101380 chr4:187894744 G/A cg27532560 chr4:187881888 NA -0.4 -6.08 -0.35 4.21e-9 Lobe attachment (rater-scored or self-reported); CESC trans rs1814175 0.585 rs4881661 chr11:50000117 A/G cg11707556 chr5:10655725 ANKRD33B -0.42 -6.12 -0.35 3.32e-9 Height; CESC cis rs1707322 0.896 rs785512 chr1:46534543 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -5.55 -0.32 7e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CESC cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg15017067 chr4:17643749 FAM184B 0.38 5.45 0.32 1.16e-7 Parasitemia in Tripanosoma cruzi seropositivity; CESC cis rs7727544 0.709 rs272852 chr5:131688767 G/A cg24060327 chr5:131705240 SLC22A5 -0.65 -8.62 -0.47 6.27e-16 Blood metabolite levels; CESC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.49 -0.37 4.09e-10 Developmental language disorder (linguistic errors); CESC cis rs858239 1.000 rs199351 chr7:23300049 A/C cg23682824 chr7:23144976 KLHL7 0.46 6.33 0.36 1.02e-9 Cerebrospinal fluid biomarker levels; CESC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg12667521 chr19:29218732 NA 0.41 6.17 0.35 2.53e-9 Methadone dose in opioid dependence; CESC cis rs6754311 0.638 rs2322659 chr2:136555659 A/G cg07169764 chr2:136633963 MCM6 -0.7 -8.87 -0.48 1.13e-16 Mosquito bite size; CESC cis rs10744422 1.000 rs4759355 chr12:123316566 A/G cg22842854 chr12:123319900 HIP1R -0.61 -5.17 -0.3 4.53e-7 Schizophrenia; CESC cis rs1144333 0.655 rs114383686 chr1:76325327 C/T cg22875332 chr1:76189707 ACADM 0.52 5.08 0.3 7.1e-7 Attention function in attention deficit hyperactive disorder; CESC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg22968622 chr17:43663579 NA 1.32 17.92 0.74 1.34e-47 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg13436879 chr15:41136556 SPINT1 0.53 6.15 0.35 2.78e-9 Gut microbiome composition (summer); CESC cis rs2228479 0.850 rs11076623 chr16:89844120 G/T cg06558623 chr16:89946397 TCF25 1.16 9.27 0.49 6.64e-18 Skin colour saturation; CESC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg23758822 chr17:41437982 NA 1.0 14.95 0.68 4.7e-37 Menopause (age at onset); CESC cis rs79349575 0.783 rs4793991 chr17:47001801 A/G cg16584676 chr17:46985605 UBE2Z 0.54 6.7 0.38 1.24e-10 Type 2 diabetes; CESC cis rs60843830 1.000 rs3791223 chr2:222336 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.77 9.68 0.51 3.6e-19 Spherical equivalent (joint analysis main effects and education interaction); CESC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg18402987 chr7:1209562 NA 0.75 7.49 0.42 1.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CESC cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg17294928 chr15:75287854 SCAMP5 -0.74 -8.61 -0.47 6.72e-16 Blood trace element (Zn levels); CESC cis rs9611565 0.559 rs132768 chr22:42013523 C/A cg06481639 chr22:41940642 POLR3H 0.6 6.14 0.35 2.95e-9 Vitiligo; CESC cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg24110177 chr3:50126178 RBM5 -0.52 -7.06 -0.4 1.42e-11 Intelligence (multi-trait analysis); CESC cis rs7216064 1.000 rs62084214 chr17:65843325 C/G cg12091567 chr17:66097778 LOC651250 -0.86 -8.83 -0.48 1.49e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CESC trans rs9467711 0.606 rs9348709 chr6:26360311 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -6.87 -0.39 4.66e-11 Autism spectrum disorder or schizophrenia; CESC cis rs3760982 0.585 rs68073292 chr19:44291401 T/C cg11993925 chr19:44307056 LYPD5 0.33 5.68 0.33 3.62e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CESC trans rs2847281 0.587 rs2542152 chr18:12782761 C/T cg23134520 chr20:44485949 ACOT8;ZSWIM3 -0.49 -6.44 -0.37 5.52e-10 C-reactive protein levels;Esophageal cancer (squamous cell); CESC cis rs2963155 0.518 rs852978 chr5:142690596 T/C cg17617527 chr5:142782415 NR3C1 0.82 7.82 0.43 1.28e-13 Breast cancer; CESC cis rs17433780 0.808 rs1074541 chr1:89509499 A/G cg09516651 chr1:89888402 LOC400759 0.7 10.7 0.55 1.94e-22 Carotid intima media thickness; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00966591 chr1:20126388 TMCO4 0.63 6.74 0.38 9.59e-11 Gut microbiome composition (summer); CESC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg02034447 chr16:89574710 SPG7 0.44 5.61 0.33 5.06e-8 Multiple myeloma (IgH translocation); CESC cis rs9902453 1.000 rs7223786 chr17:28332107 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -7.83 -0.43 1.15e-13 Coffee consumption (cups per day); CESC cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 5.69 0.33 3.42e-8 Colorectal cancer; CESC cis rs3815700 1.000 rs10407204 chr19:33097353 C/T cg02997394 chr19:33096574 ANKRD27 0.71 7.25 0.41 4.59e-12 Eosinophilic esophagitis; CESC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 5.11 0.3 6.11e-7 Bipolar disorder; CESC trans rs6089829 0.889 rs6062773 chr20:61663262 G/C cg23505145 chr19:12996616 KLF1 0.52 6.74 0.38 1e-10 Prostate cancer (SNP x SNP interaction); CESC cis rs317689 0.876 rs547332 chr12:69743639 C/G cg14784868 chr12:69753453 YEATS4 0.64 8.07 0.44 2.49e-14 Response to diuretic therapy; CESC cis rs7078219 0.523 rs10883366 chr10:101287785 G/A cg09788492 chr10:101292477 NKX2-3 0.34 6.46 0.37 5e-10 Dental caries; CESC cis rs478304 0.651 rs10896037 chr11:65503424 A/G cg10518572 chr11:65560635 OVOL1 -0.33 -6.6 -0.38 2.18e-10 Acne (severe); CESC cis rs1348850 0.519 rs1527406 chr2:178525655 C/T cg22681709 chr2:178499509 PDE11A -0.49 -7.04 -0.4 1.63e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CESC cis rs7527798 0.592 rs6684643 chr1:207846242 A/T cg21110645 chr1:207815933 NA -0.33 -5.65 -0.33 4.1e-8 Erythrocyte sedimentation rate; CESC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg07308232 chr7:1071921 C7orf50 -0.39 -5.17 -0.3 4.69e-7 Longevity;Endometriosis; CESC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg19592336 chr6:28129416 ZNF389 0.6 7.97 0.44 4.69e-14 Depression; CESC cis rs6963495 0.932 rs55700120 chr7:105148460 G/T cg13798780 chr7:105162888 PUS7 0.76 7.8 0.43 1.47e-13 Bipolar disorder (body mass index interaction); CESC trans rs12681287 0.547 rs7837569 chr8:87507366 C/T cg27317242 chr8:23145699 R3HCC1 -0.53 -6.35 -0.36 9.05e-10 Caudate activity during reward; CESC cis rs752010 0.841 rs11210498 chr1:42077958 T/G cg06885757 chr1:42089581 HIVEP3 0.47 7.63 0.42 4.21e-13 Lupus nephritis in systemic lupus erythematosus; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg04742047 chr19:14544036 PKN1 0.64 7.22 0.41 5.39e-12 Gut microbiome composition (summer); CESC cis rs863345 0.604 rs1112915 chr1:158444447 T/C cg12129480 chr1:158549410 OR10X1 -0.35 -7.05 -0.4 1.59e-11 Pneumococcal bacteremia; CESC cis rs7772486 0.790 rs10223507 chr6:146285204 C/A cg05347473 chr6:146136440 FBXO30 -0.54 -7.05 -0.4 1.6e-11 Lobe attachment (rater-scored or self-reported); CESC cis rs763121 0.925 rs5757165 chr22:38994577 C/T cg06544989 chr22:39130855 UNC84B 0.52 9.63 0.51 5.28e-19 Menopause (age at onset); CESC cis rs8016982 0.855 rs10149681 chr14:81686319 G/A cg01989461 chr14:81687754 GTF2A1 0.57 7.4 0.41 1.83e-12 Schizophrenia; CESC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg22549504 chr19:17448937 GTPBP3 0.52 5.88 0.34 1.24e-8 Systemic lupus erythematosus; CESC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg25072359 chr17:41440525 NA 0.43 5.74 0.33 2.6e-8 Menopause (age at onset); CESC cis rs5743618 0.537 rs6837838 chr4:38770576 T/A cg02016764 chr4:38805732 TLR1 -0.33 -5.16 -0.3 4.84e-7 Asthma;Allergic disease (asthma, hay fever or eczema); CESC cis rs4664308 0.870 rs1870104 chr2:161032285 A/G cg03641300 chr2:160917029 PLA2R1 -0.61 -8.95 -0.48 6.4e-17 Idiopathic membranous nephropathy; CESC cis rs7551222 0.752 rs10900599 chr1:204541943 T/C cg20240347 chr1:204465584 NA -0.27 -5.52 -0.32 8.01e-8 Schizophrenia; CESC trans rs6445975 1.000 rs4076852 chr3:58375286 C/T cg07035315 chr22:18483421 MICAL3 0.44 6.08 0.35 4.11e-9 Systemic lupus erythematosus; CESC cis rs9287719 0.901 rs4555317 chr2:10744247 A/G cg02196655 chr2:10830764 NOL10 -0.38 -5.83 -0.34 1.61e-8 Prostate cancer; CESC cis rs7267979 0.816 rs6115094 chr20:25210827 A/G cg08601574 chr20:25228251 PYGB 0.39 5.6 0.33 5.47e-8 Liver enzyme levels (alkaline phosphatase); CESC cis rs2439831 1.000 rs101094 chr15:43787322 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.58 0.54 4.72e-22 Lung cancer in ever smokers; CESC cis rs6815814 0.950 rs66819621 chr4:38819403 A/G cg02016764 chr4:38805732 TLR1 -0.56 -6.31 -0.36 1.15e-9 Breast cancer; CESC cis rs8078723 1.000 rs4795418 chr17:38164851 T/C cg17467752 chr17:38218738 THRA 0.69 10.54 0.54 6.17e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CESC cis rs344364 0.511 rs1742463 chr16:1946110 A/G cg26617929 chr16:1858877 NA -0.49 -5.15 -0.3 5.09e-7 Glomerular filtration rate in chronic kidney disease; CESC cis rs2235642 0.821 rs2281234 chr16:1602938 A/G cg03715980 chr16:1756201 MAPK8IP3 0.38 5.05 0.3 8.33e-7 Coronary artery disease; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg17100696 chr17:71088862 SLC39A11 0.58 6.26 0.36 1.51e-9 Gut microbiome composition (summer); CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg05168842 chr11:61584319 FADS1 0.59 7.01 0.4 1.97e-11 Gut microbiome composition (summer); CESC cis rs709400 0.663 rs11624367 chr14:103892818 T/A cg12935359 chr14:103987150 CKB -0.56 -8.21 -0.45 9.64e-15 Body mass index; CESC cis rs1595825 0.891 rs7595819 chr2:198543156 A/C cg10820045 chr2:198174542 NA -0.42 -5.2 -0.3 3.89e-7 Ulcerative colitis; CESC trans rs9937837 0.918 rs41477949 chr16:31287427 A/T cg04903759 chr3:167238645 WDR49 0.52 6.29 0.36 1.28e-9 Systemic lupus erythematosus; CESC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg02269571 chr22:50332266 NA -0.56 -6.99 -0.39 2.26e-11 Schizophrenia; CESC trans rs12699921 0.735 rs4466298 chr7:17992014 C/T cg17340796 chr11:85339599 TMEM126B;DLG2 -0.44 -6.04 -0.35 5.21e-9 Fibrinogen levels; CESC trans rs360798 0.532 rs1906201 chr2:62806373 C/T cg07814414 chr15:31774773 NA -0.41 -6.09 -0.35 3.88e-9 Coronary artery disease; CESC cis rs7193541 0.684 rs7191665 chr16:74688948 T/G cg05580060 chr16:74700937 RFWD3 -0.49 -6.3 -0.36 1.27e-9 Multiple myeloma; CESC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg00910521 chr17:75484950 SEPT9 -0.63 -7.05 -0.4 1.59e-11 Gut microbiome composition (summer); CESC cis rs12142240 0.698 rs1475388 chr1:46816465 G/A cg10495392 chr1:46806563 NSUN4 0.57 6.28 0.36 1.39e-9 Menopause (age at onset); CESC cis rs11148252 0.574 rs7139495 chr13:53283318 A/G cg00495681 chr13:53174319 NA 0.59 8.24 0.45 8.2e-15 Lewy body disease; CESC cis rs870825 0.616 rs4615214 chr4:185624129 G/C cg04058563 chr4:185651563 MLF1IP 0.64 7.05 0.4 1.59e-11 Blood protein levels; CESC cis rs4906332 1.000 rs34347076 chr14:103955069 G/A cg09975044 chr14:104007538 NA 0.47 6.39 0.37 7.49e-10 Coronary artery disease;